ENSMUST00000000001.5 Gnai3 ENSMUST00000000001.5 G protein subunit alpha i3 (from RefSeq NM_010306.3) A2AE36 ENSMUST00000000001.1 ENSMUST00000000001.2 ENSMUST00000000001.3 ENSMUST00000000001.4 GNAI3_MOUSE NM_010306 Q3TGV1 Q61019 Q9DC51 uc008qyd.1 uc008qyd.2 uc008qyd.3 uc008qyd.4 Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels. Stimulates the activity of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha subunit contains the guanine nucleotide binding site. GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins (By similarity). Forms a complex with CCDC88A/GIV and EGFR which leads to enhanced EGFR signaling and triggering of cell migration; ligand stimulation is required for recruitment of GNAI3 to the complex (By similarity). Interacts (inactive GDP-bound form) with CCDC88A/GIV (via GBA motif); the interaction leads to activation of GNAI3 (By similarity). Interacts (inactive GDP-bound form) with CCDC88C/DAPLE (via GBA motif); the interaction leads to activation of GNAI3 (By similarity). Interacts (inactive GDP-bound form) with NUCB1 (via GBA motif) and NUCB2 (via GBA motif); the interaction leads to activation of GNAI3 (By similarity). Interacts (inactive GDP-bound form) with PLCD4 (via GBA motif); the interaction leads to activation of GNAI3 (By similarity). Interacts with INSR; the interaction is probably mediated by CCDC88A/GIV (By similarity). Interacts with GPSM1 (PubMed:16009138). Interacts (GDP-bound form) with GPSM2 (via GoLoco domains). Does not interact with RGS2. Interacts with RGS8 and RGS10; this strongly enhances the intrinsic GTPase activity. Interacts with RGS16; this strongly enhances the intrinsic GTPase activity (By similarity). Interacts with RGS12 (By similarity). Interacts (via active GTP- or inactive GDP-bound form) with RGS14 (By similarity). Q9DC51; P09405: Ncl; NbExp=4; IntAct=EBI-641852, EBI-641864; Cytoplasm Cell membrane ; Lipid-anchor Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. Belongs to the G-alpha family. G(i/o/t/z) subfamily. Golgi membrane nucleotide binding G-protein coupled receptor binding GTPase activity protein binding GTP binding nucleus nucleolus cytoplasm endoplasmic reticulum membrane Golgi apparatus centrosome microtubule organizing center heterotrimeric G-protein complex cytoskeleton plasma membrane vesicle fusion cell cycle signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway dopamine receptor signaling pathway brain development membrane positive regulation of macroautophagy guanyl nucleotide binding GDP binding protein domain specific binding midbody G-protein beta/gamma-subunit complex binding G-protein coupled serotonin receptor binding GTPase activating protein binding positive regulation of superoxide anion generation positive regulation of NAD(P)H oxidase activity zymogen granule membrane raft GTP metabolic process metal ion binding cell division positive regulation of vascular smooth muscle cell proliferation negative regulation of apoptotic signaling pathway regulation of heart contraction uc008qyd.1 uc008qyd.2 uc008qyd.3 uc008qyd.4 
ENSMUST00000000003.14 Pbsn ENSMUST00000000003.14 probasin (from RefSeq NM_017471.3) ENSMUST00000000003.1 ENSMUST00000000003.10 ENSMUST00000000003.11 ENSMUST00000000003.12 ENSMUST00000000003.13 ENSMUST00000000003.2 ENSMUST00000000003.3 ENSMUST00000000003.4 ENSMUST00000000003.5 ENSMUST00000000003.6 ENSMUST00000000003.7 ENSMUST00000000003.8 ENSMUST00000000003.9 NM_017471 Pbsn Q3UV89 Q3UV89_MOUSE uc009tqr.1 uc009tqr.2 uc009tqr.3 Secreted Belongs to the calycin superfamily. Lipocalin family. small molecule binding uc009tqr.1 uc009tqr.2 uc009tqr.3 
ENSMUST00000000010.9 Hoxb9 ENSMUST00000000010.9 homeobox B9 (from RefSeq NM_008270.2) A2A9Z6 ENSMUST00000000010.1 ENSMUST00000000010.2 ENSMUST00000000010.3 ENSMUST00000000010.4 ENSMUST00000000010.5 ENSMUST00000000010.6 ENSMUST00000000010.7 ENSMUST00000000010.8 HXB9_MOUSE Hox-2.5 Hoxb-9 NM_008270 P20615 uc007lbn.1 uc007lbn.2 uc007lbn.3 uc007lbn.4 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus. Belongs to the Abd-B homeobox family. DNA binding nucleus nucleoplasm mitochondrion transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification mammary gland development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system development cell chemotaxis RNA polymerase II transcription factor complex RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding uc007lbn.1 uc007lbn.2 uc007lbn.3 uc007lbn.4 
ENSMUST00000000028.14 Cdc45 ENSMUST00000000028.14 cell division cycle 45, transcript variant 1 (from RefSeq NM_009862.3) CDC45_MOUSE Cdc45l Cdc45l2 ENSMUST00000000028.1 ENSMUST00000000028.10 ENSMUST00000000028.11 ENSMUST00000000028.12 ENSMUST00000000028.13 ENSMUST00000000028.2 ENSMUST00000000028.3 ENSMUST00000000028.4 ENSMUST00000000028.5 ENSMUST00000000028.6 ENSMUST00000000028.7 ENSMUST00000000028.8 ENSMUST00000000028.9 NM_009862 O70547 Q9QUK1 Q9R212 Q9Z1X9 uc007yom.1 uc007yom.2 uc007yom.3 Required for initiation of chromosomal DNA replication. Associated with ORC2. Interacts with HELB (By similarity). Component of the CMG helicase complex, composed of the MCM2-7 complex, the GINS complex and CDC45 (By similarity). Nucleus. Widely expressed. Belongs to the CDC45 family. double-strand break repair via break-induced replication chromatin binding DNA replication origin binding single-stranded DNA binding nucleus nuclear pre-replicative complex centrosome DNA replication DNA replication initiation cell cycle DNA replication preinitiation complex replication fork protection complex regulation of chromatin silencing at telomere DNA duplex unwinding 3'-5' DNA helicase activity positive regulation of G1/S transition of mitotic cell cycle mitotic DNA replication preinitiation complex assembly uc007yom.1 uc007yom.2 uc007yom.3 
ENSMUST00000000049.6 Apoh ENSMUST00000000049.6 apolipoprotein H (from RefSeq NM_013475.4) APOH_MOUSE B2gp1 ENSMUST00000000049.1 ENSMUST00000000049.2 ENSMUST00000000049.3 ENSMUST00000000049.4 ENSMUST00000000049.5 NM_013475 Q01339 uc007mbp.1 uc007mbp.2 uc007mbp.3 uc007mbp.4 Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. Secreted. Expressed by the liver and secreted in plasma. negative regulation of endothelial cell proliferation phospholipid binding extracellular region extracellular space cytoplasm plasma membrane triglyceride metabolic process blood coagulation blood coagulation, intrinsic pathway heparin binding lipid binding cell surface negative regulation of endothelial cell migration positive regulation of triglyceride catabolic process negative regulation of angiogenesis regulation of blood coagulation negative regulation of blood coagulation animal organ regeneration plasminogen activation negative regulation of myeloid cell apoptotic process triglyceride transport very-low-density lipoprotein particle high-density lipoprotein particle negative regulation of smooth muscle cell apoptotic process chylomicron identical protein binding positive regulation of lipoprotein lipase activity regulation of fibrinolysis negative regulation of fibrinolysis lipoprotein lipase activator activity negative regulation of respiratory burst uc007mbp.1 uc007mbp.2 uc007mbp.3 uc007mbp.4 
ENSMUST00000000058.7 Cav2 ENSMUST00000000058.7 caveolin 2, transcript variant 1 (from RefSeq NM_016900.4) CAV2_MOUSE ENSMUST00000000058.1 ENSMUST00000000058.2 ENSMUST00000000058.3 ENSMUST00000000058.4 ENSMUST00000000058.5 ENSMUST00000000058.6 NM_016900 Q3TYR4 Q9WVC3 uc009azn.1 uc009azn.2 uc009azn.3 uc009azn.4 This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. This gene is located adjacent to caveolin-1 and the proteins coexpressed by the two genes localize together in caveolae, where they form hetero-oligomers. The encoded protein may be involved in diverse cellular functions including proliferation, differentiation, endocytosis and trafficking. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). Monomer or homodimer. Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity). Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin. Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments (By similarity). Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells. Phosphorylation on both Tyr- 19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity). Belongs to the caveolin family. Golgi membrane SNARE binding negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation acrosomal membrane caveolar macromolecular signaling complex nucleus nuclear envelope nuclear inner membrane cytoplasm endoplasmic reticulum Golgi apparatus lipid particle cytosol plasma membrane integral component of plasma membrane caveola focal adhesion endocytosis vesicle fusion mitochondrion organization endoplasmic reticulum organization regulation of mitotic nuclear division chemical synaptic transmission negative regulation of cell proliferation insulin receptor signaling pathway cell surface membrane vesicle organization receptor-mediated endocytosis of virus by host cell protein kinase binding syntaxin binding transport vesicle cell differentiation negative regulation of transforming growth factor beta receptor signaling pathway protein binding, bridging extrinsic component of cytoplasmic side of plasma membrane cytoplasmic vesicle mitogen-activated protein kinase kinase kinase binding D1 dopamine receptor binding macromolecular complex protein homodimerization activity positive regulation of MAPK cascade positive regulation of GTPase activity positive regulation by host of viral release from host cell positive regulation by host of viral process membrane raft protein heterodimerization activity vesicle docking perinuclear region of cytoplasm skeletal muscle fiber development positive regulation of peptidyl-tyrosine phosphorylation phosphoprotein binding binding, bridging positive regulation of dopamine receptor signaling pathway caveola assembly basement membrane organization scaffold protein binding positive regulation of protein localization to nucleus sarcolemma uc009azn.1 uc009azn.2 uc009azn.3 uc009azn.4 
ENSMUST00000000080.8 Klf6 ENSMUST00000000080.8 Kruppel-like transcription factor 6 (from RefSeq NM_011803.2) ENSMUST00000000080.1 ENSMUST00000000080.2 ENSMUST00000000080.3 ENSMUST00000000080.4 ENSMUST00000000080.5 ENSMUST00000000080.6 ENSMUST00000000080.7 Klf6 NM_011803 Q8BPQ2 Q8BPQ2_MOUSE uc007pjw.1 uc007pjw.2 uc007pjw.3 Nucleus RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding fibrillar center nucleic acid binding nucleus nucleolus cytosol intracellular membrane-bounded organelle positive regulation of transcription from RNA polymerase II promoter uc007pjw.1 uc007pjw.2 uc007pjw.3 
ENSMUST00000000087.13 Scmh1 ENSMUST00000000087.13 sex comb on midleg homolog 1, transcript variant 11 (from RefSeq NR_175812.1) B1AS51 ENSMUST00000000087.1 ENSMUST00000000087.10 ENSMUST00000000087.11 ENSMUST00000000087.12 ENSMUST00000000087.2 ENSMUST00000000087.3 ENSMUST00000000087.4 ENSMUST00000000087.5 ENSMUST00000000087.6 ENSMUST00000000087.7 ENSMUST00000000087.8 ENSMUST00000000087.9 NR_175812 Q8K214 Q9JME0 SCMH1_MOUSE Scmh1 uc008und.1 uc008und.2 uc008und.3 uc008und.4 Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes. Associates with a PRC1-like complex (By similarity). Interacts with the SAM domain of PHC1 via its SAM domain in vitro. Q8K214; O88513: Gmnn; NbExp=2; IntAct=EBI-445955, EBI-445922; Q8K214; Q64028: Phc1; NbExp=2; IntAct=EBI-445955, EBI-927346; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8K214-1; Sequence=Displayed; Name=2 ; IsoId=Q8K214-2; Sequence=VSP_051680, VSP_051681; Most abundant in testis. Moderate levels detected in heart, brain, lung, liver, skeletal muscle and kidney and lower levels in spleen. Detected throughout embryogenesis. Expressed ubiquitously in 8.5 dpc embryos. At 10.5 dpc, strongly expressed in nervous system including hindbrain and spinal cord, and in the pharyngeal arches and visceral organs. By 14.5 dpc, strong expression is detected throughout the central nervous system, and in tongue, heart, midgut and urogenital regions. By retinoic acid in F9 and F19 embryonal carcinoma cell lines. Belongs to the SCM family. protein binding nucleus chromatin remodeling regulation of transcription, DNA-templated multicellular organism development spermatogenesis anterior/posterior pattern specification chromocenter gene silencing negative regulation of transcription, DNA-templated uc008und.1 uc008und.2 uc008und.3 uc008und.4 
ENSMUST00000000090.8 Cox5a ENSMUST00000000090.8 cytochrome c oxidase subunit 5A (from RefSeq NM_007747.2) COX5A_MOUSE ENSMUST00000000090.1 ENSMUST00000000090.2 ENSMUST00000000090.3 ENSMUST00000000090.4 ENSMUST00000000090.5 ENSMUST00000000090.6 ENSMUST00000000090.7 NM_007747 P12787 Q9D2W1 uc009puz.1 uc009puz.2 uc009puz.3 uc009puz.4 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Energy metabolism; oxidative phosphorylation. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with AFG1L (By similarity). Interacts with RAB5IF (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the cytochrome c oxidase subunit 5A family. cytochrome-c oxidase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex IV mitochondrial electron transport, cytochrome c to oxygen membrane myelin sheath metal ion binding hydrogen ion transmembrane transport uc009puz.1 uc009puz.2 uc009puz.3 uc009puz.4 
ENSMUST00000000095.7 Tbx2 ENSMUST00000000095.7 T-box 2 (from RefSeq NM_009324.2) ENSMUST00000000095.1 ENSMUST00000000095.2 ENSMUST00000000095.3 ENSMUST00000000095.4 ENSMUST00000000095.5 ENSMUST00000000095.6 NM_009324 Q5SSP7 Q60707 TBX2_MOUSE uc007ksb.1 uc007ksb.2 uc007ksb.3 Transcription factor which acts as a transcriptional repressor (PubMed:22186728, PubMed:11867218, PubMed:18025091, PubMed:12023302). May also function as a transcriptional activator (PubMed:26486273, PubMed:22186728, PubMed:11867218). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half- site, which are present in the regulatory region of several genes (PubMed:9710594, PubMed:26971330, PubMed:12023302, PubMed:33731112, PubMed:27720610). Required for cardiac atrioventricular canal formation (PubMed:15459098). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (PubMed:12023302). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (PubMed:22186728). Plays a role in limb pattern formation (PubMed:15459098). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (PubMed:27720610, PubMed:16222716). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (PubMed:27720610). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (PubMed:33795231). Acts as a negative regulator of PML function in cellular senescence (By similarity). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (PubMed:18025091, PubMed:33731112). Negatively modulates expression of CDKN2A/p19ARF and CDH1/E-cadherin (By similarity). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (By similarity). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (PubMed:26486273). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (PubMed:26971330, PubMed:9710594). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). Binds DNA as a monomer (By similarity). Interacts with CHD4, HDAC1 and HDAC2, perhaps as components of a NuRD-like complex (PubMed:33731112). Interacts with CBX3, HMGB2 and PBX1 (PubMed:33731112). Interacts with PML (By similarity). Nucleus In adults, highest levels in lung. Also found in heart, kidney, and ovary. Expressed in the otic placode at 8.5 dpc (at protein level) (PubMed:33795231). Between 10.5-12.0 dpc, expressed in various regions of the developing ear, including the cochlear duct, endolymphatic duct and the vestibule, but not in the region which gives rise to the posterior and anterior semicircular canals (at protein level) (PubMed:33795231). Expressed at 8.5 dpc in the cardiac crescent, the atrium and the inflow tract (IFT) (PubMed:15459098). Expressed at 9.5 dpc in the otic and optic vesicles, facial region, septum transversum, bilateral nephrogenic mesodermal cords, ventral body wall mesoderm caudal to the forelimbs, pharyngeal arch mesenchyme that contains neural crest cells, including those migrating into the outflow tract (OFT), septum OFT, inner curvature, atrioventricular canal (AVC) and IFT of the heart (PubMed:7920656, PubMed:8853987, PubMed:15459098, PubMed:33795231). Expressed in a continuous stripe of mesenchyme in the ventro-lateral body wall between the fore and hind limb buds at day 10.5-11.5 dpc (PubMed:16222716). At 12.5 dpc, expressed in the trigeminal ganglia, facial regions, retina and limb bud mesenchyme (PubMed:8853987). In later stages, found in ear pinnae, the milk line, lung mesenchyme, body wall, genital ridge and developing nervous system (PubMed:8853987, PubMed:33731112). Expressed in proliferating retinal pigment epithelium (RPE) cells at 14.5 dpc, and continues after birth, but diminishes by postnatal day 90 (PubMed:28910203). Expressed in melanocytes of postnatal day 3 hair follicles (PubMed:26486273). Repression domain 1 (RD1) is involved in transcriptional repression (By similarity). RD1 is necessary for its interaction with PML (By similarity). Phosphorylated (PubMed:18025091). May be phosphorylated by p38 MAPK in response to UV irradiation stress (PubMed:18025091). Knockouts do not survive beyond embryonic 14.5 dpc (PubMed:15459098). Abnormal atrioventricular morphology at 9.5-10.5 dpc and outflow tract (OFT) septation defects in those surviving to 12.5 dpc (PubMed:15459098). Hindlimb digit duplication at 14.5 dpc (PubMed:15459098). Increased expression of CDKN1A, FRZB, IL33, SHISA3, and CCN4/WISP1 in lung mesenchyme between 12.5-14.5 dpc (PubMed:33731112). Conditional knockdown targeted mainly to lung mesenchyme causes lung hypoplasia at 18.5 dpc (PubMed:27720610). Conditional knockdown targeted mainly to the otic epithelium disrupts inner ear morphogenesis, which is exacerbated by simultaneous conditional knockdown of TBX3 (PubMed:33795231). Simultaneous conditional knockdown of TBX2 and TBX3 targeted mainly to lung mesenchyme causes severe bleeding from 10.5 dpc and embryos die shortly thereafter, perhaps as a result of knockdown in the developing heart (PubMed:27720610). Sequence=AAC52697.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cell fate specification heart looping heart morphogenesis outflow tract septum morphogenesis outflow tract morphogenesis endocardial cushion morphogenesis cardiac chamber development regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated Notch signaling pathway multicellular organism development central nervous system development muscle cell fate determination cell aging regulation of heart contraction positive regulation of cell proliferation embryonic heart tube development aorta morphogenesis atrioventricular canal development embryonic digit morphogenesis sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic camera-type eye morphogenesis cardiac muscle tissue development palate development positive regulation of cardiac muscle cell proliferation pharynx development developmental growth involved in morphogenesis mammary placode formation cellular senescence negative regulation of heart looping negative regulation of cardiac chamber formation uc007ksb.1 uc007ksb.2 uc007ksb.3 
ENSMUST00000000122.7 Ngfr ENSMUST00000000122.7 nerve growth factor receptor (TNFR superfamily, member 16) (from RefSeq NM_033217.3) ENSMUST00000000122.1 ENSMUST00000000122.2 ENSMUST00000000122.3 ENSMUST00000000122.4 ENSMUST00000000122.5 ENSMUST00000000122.6 NM_033217 Q8CFT3 Q9Z0W1 TNR16_MOUSE Tnfrsf16 uc007lam.1 uc007lam.2 uc007lam.3 uc007lam.4 uc007lam.5 Low affinity neurotrophin receptor which can bind to mature NGF, BDNF, NTF3, and NTF4 (PubMed:11559852, PubMed:1317267). Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF (proNGF), BDNF (proBDNF) and NTF3 (proNT3) with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:22155786, PubMed:24908487, PubMed:27457814). Plays an important role in differentiation and survival of specific neuronal populations during development (PubMed:1317267, PubMed:11559852). Can mediate cell survival as well as cell death of neural cells (PubMed:1317267, PubMed:11559852, PubMed:24908487). The heterodimeric receptor formed with SORCS2 plays a role in proBDNF-dependent synaptic plasticity, in hippocampal long term depression (LTD) and long term potentiation (LTP) (PubMed:27457814). Plays a role in the inactivation of RHOA (By similarity). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (PubMed:22460790). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). (Microbial infection) Cell surface receptor for rabies virus glycoprotein Gs. [Isoform 2]: Does not bind NGF, BDNF, NTF3, and NTF4. Homodimer; disulfide-linked. Heterodimer with SORCS2 (PubMed:22155786, PubMed:24908487, PubMed:27457814). The extracellular domains of the heterodimer bind NGF. The cytoplasmic region of the heterodimer binds TRIO. NGF binding mediates dissociation of TRIO from the receptor complex (PubMed:22155786). Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 (By similarity). Interacts with BEX3 (PubMed:11830582). Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts (via death domain) with RAB31 (PubMed:22460790). Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor (PubMed:11559852). Interacts with LINGO1. Interacts with NRADD. Interacts with MAGED1; the interaction antagonizes the association NGFR:NTRK1 (By similarity). Interacts with RTN4R (PubMed:22923615). Interacts (via death domain) with ARHGDIA and RIPK2 (By similarity). (Microbial infection) Binds to rabies virus glycoprotein Gs. Q9Z0W1; Q9EPR5: Sorcs2; NbExp=4; IntAct=EBI-4411273, EBI-9915438; Cell membrane ingle-pass type I membrane protein Perikaryon Cell projection, growth cone Cell projection, dendritic spine Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z0W1-1; Sequence=Displayed; Name=2; Synonyms=s-p75 ; IsoId=Q9Z0W1-2; Sequence=Not described; Detected in Schwann cells (PubMed:11559852). Detected in embryonic brain, in hippocampus neurons (at protein level) (PubMed:22155786, PubMed:27457814). Detected in brain and spinal cord (PubMed:11559852). Detected in embryonic large blood vessels at 11.5 dpc. Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain and in liver. Expression seen at higher levels during the light period and lower during the dark period. The death domain mediates interaction with RANBP9 (By similarity). It also mediates interaction with ARHGDIA and RIPK2 (By similarity). The extracellular domain is responsible for interaction with NTRK1. N-glycosylated (PubMed:11559852). O-glycosylated. Phosphorylated on serine residues. Embryos are present at the expected Mendelian rate at 15.5 dpc, but mutant mice display about 40% perinatal lethality. At 11.5 dpc, mutant embryos display mildly to severely dilated blood vessels with thinner walls. The dorsal aorta is particularly affected. Many embryos show massive dilatations, ruptures and blood leakage. Surviving animals display small size and hind limb ataxia at 13 days after birth. When held by their tails, they respond by stretching their hind legs pointing upwards. The diameter of their sciatic nerve is strongly reduced. At 3 days after birth, the number of Schwann cells is strongly reduced in sciatic nerve from mutant mice. Likewise, the number of sensory neurons in dorsal root ganglia is strongly reduced (PubMed:11559852). The initially reported gene disruption experiment finds that mice are born at the expected Mendelian rate, are fertile, and have no visible phenotype when young. However, after 4 months mutant mice develop skin alterations with severe ulcers on all extremities. Already before the onset of symptoms, mutant mice display decreased skin innervation and smaller dorsal root ganglia, plus impaired heat sensitivity (PubMed:11559852). [Isoform 2]: Minor isoform that lacks exon 3. The initial gene disruption experiment found a less pronounced phenotype than that reported in a later study (PubMed:1317267, PubMed:11559852). Both experiments disrupt expression of isoform 1 and NGF binding (PubMed:1317267, PubMed:11559852). The differences may be due to the presence of isoform 2; its expression is disrupted in the later experiment, but not in the initial experiment (PubMed:11559852). Sequence=AAD17943.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; beta-amyloid binding cellular glucose homeostasis death receptor activity neurotrophin TRKA receptor binding protein binding calmodulin binding nucleus nuclear envelope cytoplasm mitochondrion rough endoplasmic reticulum Golgi apparatus plasma membrane cell-cell junction intracellular protein transport apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction Rho protein signal transduction multicellular organism development nervous system development axon guidance central nervous system development circadian rhythm response to wounding external side of plasma membrane cell surface regulation of gene expression regulation of cell death positive regulation of neuron projection development negative regulation of neuron projection development postsynaptic density coreceptor activity membrane integral component of membrane detection of temperature stimulus negative regulation of angiogenesis Rab GTPase binding sensory perception of pain nerve development coated vesicle cell differentiation growth cone hair follicle morphogenesis ubiquitin protein ligase binding positive regulation of myelination positive regulation of synaptic transmission, cholinergic dendrite membrane neuronal cell body membrane circadian regulation of gene expression cellular response to oxidative stress positive regulation of Rho protein signal transduction dorsal aorta development negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of odontogenesis of dentin-containing tooth glucose homeostasis identical protein binding protein homodimerization activity cell projection positive regulation of apoptotic process negative regulation of apoptotic process neurotrophin binding dendritic spine perikaryon positive regulation of MAPK cascade negative regulation of neuron apoptotic process skin development macromolecular complex binding membrane raft clathrin-coated endocytic vesicle positive regulation of neuron differentiation positive regulation of fibroblast proliferation nerve growth factor binding rhythmic process neuron apoptotic process negative regulation of hair follicle development positive regulation of protein kinase B signaling negative regulation of mitochondrial depolarization positive regulation of synaptic transmission, glutamatergic negative regulation of dendritic spine development preprotein binding positive regulation of protein localization to nucleus positive regulation of neuron death positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis cellular response to beta-amyloid positive regulation of neural precursor cell proliferation regulation of reactive oxygen species metabolic process positive regulation of excitatory postsynaptic potential positive regulation of apoptotic signaling pathway uc007lam.1 uc007lam.2 uc007lam.3 uc007lam.4 uc007lam.5 
ENSMUST00000000127.6 Wnt3 ENSMUST00000000127.6 wingless-type MMTV integration site family, member 3 (from RefSeq NM_009521.3) ENSMUST00000000127.1 ENSMUST00000000127.2 ENSMUST00000000127.3 ENSMUST00000000127.4 ENSMUST00000000127.5 Int-4 NM_009521 P17553 WNT3_MOUSE Wnt-3 uc007lvs.1 uc007lvs.2 uc007lvs.3 uc007lvs.4 Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis (PubMed:10431240). Required for normal formation of the apical ectodermal ridge and for normal embryonic limb development (PubMed:12569130). Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with PORCN (PubMed:10866835). Interacts with WLS (PubMed:19841259). P17553; O35082: Kl; NbExp=4; IntAct=EBI-1570853, EBI-1570828; Secreted, extracellular space, extracellular matrix Secreted Detected at low levels in adult brain (PubMed:2162045). Dorsal portion of the neural tube, dorsal ectoderm, the branchial arches, and the limb buds. Detected at 6.25 to 7.5 dpc in primitive streak, proximal epiblast, visceral endoderm and at the junction between the embryonic and extraembryonic ectoderm, with higher levels in the posterior region (PubMed:10431240, PubMed:19841259). Detected in the ectoderm at forelimb buds at 9.5 dpc (PubMed:12569130). Detected in all outgrowing limbs and in ectoderm flanking the limbs at least till 11.5 dpc (PubMed:12569130). Highly expressed in embryos at 11.5 and 12.5 dpc, with very low expression levels before and after this period (PubMed:2162045). Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. Some mouse mammary tumors induced by mouse mammary tumor virus (MMTV) contain a provirus integrated into a host cell region which has been named Wnt3. Belongs to the Wnt family. cell morphogenesis mesoderm formation receptor binding frizzled binding protein binding extracellular region extracellular space cytoplasm endoplasmic reticulum lumen signal transduction cell-cell signaling multicellular organism development gamete generation axon guidance animal organ morphogenesis anterior/posterior axis specification dorsal/ventral axis specification anterior/posterior pattern specification positive regulation of gene expression Wnt signaling pathway protein domain specific binding positive regulation of Wnt signaling pathway neuron differentiation extracellular matrix embryonic forelimb morphogenesis embryonic hindlimb morphogenesis canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in osteoblast differentiation cell fate commitment receptor agonist activity anatomical structure formation involved in morphogenesis positive regulation of collateral sprouting in absence of injury negative regulation of axon extension involved in axon guidance regulation of neurogenesis Spemann organizer formation at the anterior end of the primitive streak canonical Wnt signaling pathway limb development limb bud formation head morphogenesis mammary gland epithelium development stem cell proliferation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in stem cell proliferation uc007lvs.1 uc007lvs.2 uc007lvs.3 uc007lvs.4 
ENSMUST00000000129.14 Fer ENSMUST00000000129.14 FER tyrosine kinase, transcript variant 5 (from RefSeq NM_001403360.1) ENSMUST00000000129.1 ENSMUST00000000129.10 ENSMUST00000000129.11 ENSMUST00000000129.12 ENSMUST00000000129.13 ENSMUST00000000129.2 ENSMUST00000000129.3 ENSMUST00000000129.4 ENSMUST00000000129.5 ENSMUST00000000129.6 ENSMUST00000000129.7 ENSMUST00000000129.8 ENSMUST00000000129.9 FER_MOUSE Fert2 NM_001403360 P70451 Q61561 Q6PEE5 Q80UI3 Q8C481 Q9EQ77 uc289mib.1 uc289mib.2 Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF- kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3 according to PubMed:10878010 and PubMed:19159681, but clearly plays a redundant role in STAT3 phosphorylation. According to PubMed:11134346, cells where wild type FER has been replaced by a kinase-dead mutant show no reduction in STAT3 phosphorylation. Phosphorylates TMF1. Isoform 3 lacks kinase activity. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Activated by phosphatidic acid binding (By similarity). Activated by hydrogen peroxide (in vitro). Activated by reactive oxygen species (ROS). Homotrimer. Isoform 4 is a monomer, due to the absence of the N-terminal coiled coil domains. Interacts with CTNND1, EGFR, FLT3, PECAM1 and PDGFR. Interacts (via SH2 domain) with CTTN. Component of a complex that contains at least FER, CTTN and PTK2/FAK1 (By similarity). Interacts with IRS1 and PIK3R1. Interacts with STAT3. Interacts with PPP1CA and regulates its phosphorylation at 'Thr-320'. Interacts with JAK1. Interacts with HSP90; this stabilizes phosphorylated FER and protects FER against proteasomal degradation. Interacts with ARHGDIA, NRP1, PLEC and TMF1. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection Cell junction Membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus. Cytoplasm, cell cortex Note=Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts (By similarity). Not detected in the nucleus, but detected in the nuclear area surrounding the chromosomes after breakdown of the nuclear envelope during mitosis (PubMed:11339827). [Isoform 4]: Nucleus. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P70451-1; Sequence=Displayed; Name=2; IsoId=P70451-2; Sequence=VSP_021634; Name=3; Synonyms=iFer; IsoId=P70451-3; Sequence=VSP_041769, VSP_041770; Name=4; Synonyms=FerT, p51FerT; IsoId=P70451-4; Sequence=VSP_041766, VSP_041767, VSP_041768; Name=5; IsoId=P70451-5; Sequence=VSP_041768; Detected in liver and testis. Isoform 4 is detected only in testis (at protein level). Widely expressed. Up-regulated by insulin in myogenic cells (in vitro). The coiled coil domains mediate homooligomerization and are required for location at microtubules. The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes. Autophosphorylated. Polyubiquitinated; this leads to proteasomal degradation. No visible phenotype, and the mice are fertile. Mice have reduced CTTN phosphorylation. Mice lacking both Fps/Fes and Fer activity are viable and fertile, but produce slightly fewer pups per litter than normal. They display elevated levels of circulating neutrophils, erythrocytes and platelets, while other cell counts are normal. Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle nuclear chromatin regulation of protein phosphorylation actin binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding epidermal growth factor receptor binding protein binding ATP binding nucleus cytoplasm cytosol cytoskeleton plasma membrane cell cortex protein phosphorylation chemotaxis cell adhesion signal transduction transmembrane receptor protein tyrosine kinase signaling pathway tyrosine phosphorylation of STAT protein cytoskeletal protein binding protein phosphatase 1 binding cell proliferation positive regulation of cell proliferation lipid binding regulation of lamellipodium assembly regulation of fibroblast migration actin cytoskeleton microtubule cytoskeleton membrane kinase activity phosphorylation cell migration transferase activity Rab GTPase binding peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway protein kinase binding lamellipodium cell junction cell differentiation positive regulation of cell migration positive regulation of actin filament polymerization extrinsic component of cytoplasmic side of plasma membrane actin cytoskeleton reorganization response to lipopolysaccharide cellular response to insulin stimulus negative regulation of mast cell activation involved in immune response substrate adhesion-dependent cell spreading cellular response to reactive oxygen species extracellular matrix-cell signaling cellular response to macrophage colony-stimulating factor stimulus response to platelet-derived growth factor insulin receptor signaling pathway via phosphatidylinositol 3-kinase peptidyl-tyrosine autophosphorylation Fc-epsilon receptor signaling pathway Kit signaling pathway regulation of epidermal growth factor receptor signaling pathway regulation of cell proliferation cell projection regulation of mast cell degranulation cell-cell adhesion mediated by cadherin gamma-catenin binding cadherin binding protein autophosphorylation platelet-derived growth factor receptor signaling pathway cell adhesion molecule binding diapedesis positive regulation of NF-kappaB transcription factor activity interleukin-6-mediated signaling pathway uc289mib.1 uc289mib.2 
ENSMUST00000000137.8 Actr2 ENSMUST00000000137.8 actin related protein 2, transcript variant 2 (from RefSeq NM_146243.2) Actr2 ENSMUST00000000137.1 ENSMUST00000000137.2 ENSMUST00000000137.3 ENSMUST00000000137.4 ENSMUST00000000137.5 ENSMUST00000000137.6 ENSMUST00000000137.7 NM_146243 Q5SW83 Q5SW83_MOUSE uc011xrw.1 uc011xrw.2 uc011xrw.3 Belongs to the actin family. ARP2 subfamily. nucleotide binding actin binding structural constituent of cytoskeleton ATP binding nucleus cytoplasm cytoskeleton Arp2/3 protein complex actin filament organization cytoskeletal protein binding associative learning postsynaptic density lamellipodium Arp2/3 complex-mediated actin nucleation site of double-strand break response to immobilization stress cellular response to trichostatin A response to ethanol positive regulation of transcription from RNA polymerase II promoter actin filament binding cilium assembly positive regulation of dendritic spine morphogenesis invadopodium postsynapse positive regulation of double-strand break repair via homologous recombination uc011xrw.1 uc011xrw.2 uc011xrw.3 
ENSMUST00000000153.9 Gna12 ENSMUST00000000153.9 guanine nucleotide binding protein, alpha 12 (from RefSeq NM_010302.2) ENSMUST00000000153.1 ENSMUST00000000153.2 ENSMUST00000000153.3 ENSMUST00000000153.4 ENSMUST00000000153.5 ENSMUST00000000153.6 ENSMUST00000000153.7 ENSMUST00000000153.8 GNA12_MOUSE Gna-12 NM_010302 P27600 uc009aih.1 uc009aih.2 uc009aih.3 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:19151758, PubMed:21212405, PubMed:22609986). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (By similarity). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (PubMed:19151758, PubMed:21212405). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro- inflammatory cytokine production (By similarity). Inhibits CDH1- mediated cell adhesion in process independent from Rho activation (By similarity). Together with NAPA promotes CDH5 localization to plasma membrane (By similarity). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986). G proteins are composed of 3 units; alpha, beta and gamma (PubMed:16388592). The alpha chain contains the guanine nucleotide binding site (PubMed:16388592). Interacts with UBXD5 (By similarity). Interacts (in GTP-bound form) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane (By similarity). Interacts with RGS22 (By similarity). Interacts (via N-terminus) with NAPA; the interaction promotes CDH5 localization to plasma membrane (By similarity). Interacts with CTNND1 (via N- terminus); the interaction regulates CDH1-mediated cell-cell adhesion (PubMed:15240885). Interacts with PPP2R1A; the interaction promotes protein phosphatase 2A activation causing dephosphorylation of MAPT (By similarity). Interacts (in GTP-bound form) with ARHGEF1 (PubMed:16388592). Interacts (in GTP-bound form) with ARHGEF11 (via RGS domain) (By similarity). Interacts (in GTP-bound form) with ARHGEF12 (via RGS domain) (PubMed:16388592). Cell membrane ; Lipid-anchor Lateral cell membrane ; Lipid-anchor Cytoplasm Note=CDH1 enhances cell membrane localization. Myristoylation of mutated N-terminus in place of original palmitoylation restores the transformation activity. Belongs to the G-alpha family. G(12) subfamily. nucleotide binding G-protein coupled receptor binding in utero embryonic development GTPase activity GTP binding cytoplasm heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway Rho protein signal transduction regulation of cell shape regulation of fibroblast migration membrane lateral plasma membrane guanyl nucleotide binding cell differentiation brush border membrane G-protein beta/gamma-subunit complex binding D5 dopamine receptor binding regulation of TOR signaling regulation of proteasomal ubiquitin-dependent protein catabolic process intracellular signal transduction response to drug embryonic digit morphogenesis metal ion binding uc009aih.1 uc009aih.2 uc009aih.3 
ENSMUST00000000163.13 Igsf5 ENSMUST00000000163.13 immunoglobulin superfamily, member 5, transcript variant 2 (from RefSeq NM_001177887.1) A0A0B4J1E1 A0A0B4J1E1_MOUSE ENSMUST00000000163.1 ENSMUST00000000163.10 ENSMUST00000000163.11 ENSMUST00000000163.12 ENSMUST00000000163.2 ENSMUST00000000163.3 ENSMUST00000000163.4 ENSMUST00000000163.5 ENSMUST00000000163.6 ENSMUST00000000163.7 ENSMUST00000000163.8 ENSMUST00000000163.9 Igsf5 NM_001177887 uc008acy.1 uc008acy.2 uc008acy.3 uc008acy.4 uc008acy.5 membrane integral component of membrane uc008acy.1 uc008acy.2 uc008acy.3 uc008acy.4 uc008acy.5 
ENSMUST00000000171.15 Pih1d2 ENSMUST00000000171.15 PIH1 domain containing 2 (from RefSeq NM_028300.2) ENSMUST00000000171.1 ENSMUST00000000171.10 ENSMUST00000000171.11 ENSMUST00000000171.12 ENSMUST00000000171.13 ENSMUST00000000171.14 ENSMUST00000000171.2 ENSMUST00000000171.3 ENSMUST00000000171.4 ENSMUST00000000171.5 ENSMUST00000000171.6 ENSMUST00000000171.7 ENSMUST00000000171.8 ENSMUST00000000171.9 NM_028300 PIHD2_MOUSE Q05CZ6 Q8CHR9 Q9CSM2 uc009pjz.1 uc009pjz.2 uc009pjz.3 uc009pjz.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CHR9-1; Sequence=Displayed; Name=2; IsoId=Q8CHR9-2; Sequence=VSP_028718, VSP_028719; Belongs to the PIH1 family. Sequence=AAH19481.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; box C/D snoRNP assembly cytoplasm rRNA processing Ral GTPase binding R2TP complex uc009pjz.1 uc009pjz.2 uc009pjz.3 uc009pjz.4 
ENSMUST00000000175.6 Sdhd ENSMUST00000000175.6 succinate dehydrogenase complex, subunit D, integral membrane protein (from RefSeq NM_025848.3) A6H629 DHSD_MOUSE ENSMUST00000000175.1 ENSMUST00000000175.2 ENSMUST00000000175.3 ENSMUST00000000175.4 ENSMUST00000000175.5 NM_025848 Q3UX11 Q9CXV1 uc009pjv.1 uc009pjv.2 uc009pjv.3 uc009pjv.4 Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Carbohydrate metabolism; tricarboxylic acid cycle. Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the CybS family. succinate dehydrogenase activity mitochondrion mitochondrial envelope mitochondrial inner membrane mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) tricarboxylic acid cycle mitochondrial electron transport, succinate to ubiquinone succinate dehydrogenase (ubiquinone) activity membrane integral component of membrane heme binding metal ion binding ubiquinone binding regulation of catecholamine secretion oxidation-reduction process cellular response to hypoxia uc009pjv.1 uc009pjv.2 uc009pjv.3 uc009pjv.4 
ENSMUST00000000186.9 Fgf23 ENSMUST00000000186.9 fibroblast growth factor 23 (from RefSeq NM_022657.5) ENSMUST00000000186.1 ENSMUST00000000186.2 ENSMUST00000000186.3 ENSMUST00000000186.4 ENSMUST00000000186.5 ENSMUST00000000186.6 ENSMUST00000000186.7 ENSMUST00000000186.8 FGF23_MOUSE NM_022657 Q9EPC2 uc009dvp.1 uc009dvp.2 uc009dvp.3 uc009dvp.4 This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function. [provided by RefSeq, Mar 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK155687.1, AF263536.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Up-regulates EGR1 expression in the presence of KL (PubMed:17086194). Interacts with FGFR1 (PubMed:17086194). Interacts with FGFR2, FGFR3 and FGFR4 (By similarity). Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors (PubMed:17086194). Secreted Note=Secretion is dependent on O-glycosylation. Mainly expressed in the brain and thymus at low levels. In brain; preferentially expressed in the ventrolateral thalamic nucleus. Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases (By similarity). O-glycosylated at Thr-171 and Thr-178 by GALNT3 and glycosylation of Thr-178 requires previous glycosylation at Thr171. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23 (By similarity). Phosphorylation at Ser-180 mediated by FAM20C slows down glycosylation at Thr-178 notably. Belongs to the heparin-binding growth factors family. MAPK cascade fibroblast growth factor receptor binding type 1 fibroblast growth factor receptor binding protein binding extracellular region extracellular space cell phosphate-containing compound metabolic process growth factor activity fibroblast growth factor receptor signaling pathway regulation of phosphate transport positive regulation of vitamin D 24-hydroxylase activity cell differentiation regulation of bone mineralization negative regulation of bone mineralization cellular phosphate ion homeostasis response to magnesium ion vitamin D metabolic process vitamin D catabolic process cellular response to leptin stimulus negative regulation of osteoblast differentiation positive regulation of transcription, DNA-templated negative regulation of hormone secretion phosphate ion homeostasis positive regulation of ERK1 and ERK2 cascade cellular response to vitamin D cellular response to interleukin-6 cellular response to parathyroid hormone stimulus positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway response to sodium phosphate uc009dvp.1 uc009dvp.2 uc009dvp.3 uc009dvp.4 
ENSMUST00000000187.7 Fgf6 ENSMUST00000000187.7 fibroblast growth factor 6 (from RefSeq NM_010204.1) ENSMUST00000000187.1 ENSMUST00000000187.2 ENSMUST00000000187.3 ENSMUST00000000187.4 ENSMUST00000000187.5 ENSMUST00000000187.6 FGF6_MOUSE Fgf-6 Hstf2 NM_010204 P21658 uc009dvo.1 uc009dvo.2 uc009dvo.3 Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity). Secreted, extracellular space. Embryos, adult muscles and adult testis. Belongs to the heparin-binding growth factors family. cartilage condensation angiogenesis extracellular region extracellular space multicellular organism development growth factor activity positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway cell differentiation sarcolemma myoblast differentiation positive regulation of cell division uc009dvo.1 uc009dvo.2 uc009dvo.3 
ENSMUST00000000188.12 Ccnd2 ENSMUST00000000188.12 cyclin D2 (from RefSeq NM_009829.3) Ccnd2 ENSMUST00000000188.1 ENSMUST00000000188.10 ENSMUST00000000188.11 ENSMUST00000000188.2 ENSMUST00000000188.3 ENSMUST00000000188.4 ENSMUST00000000188.5 ENSMUST00000000188.6 ENSMUST00000000188.7 ENSMUST00000000188.8 ENSMUST00000000188.9 NM_009829 Q4FK45 Q4FK45_MOUSE uc009dvr.1 uc009dvr.2 uc009dvr.3 uc009dvr.4 Membrane Nucleus membrane Belongs to the cyclin family. Cyclin D subfamily. nucleus uc009dvr.1 uc009dvr.2 uc009dvr.3 uc009dvr.4 
ENSMUST00000000193.6 Ccl2 ENSMUST00000000193.6 C-C motif chemokine ligand 2 (from RefSeq NM_011333.3) Ccl2 ENSMUST00000000193.1 ENSMUST00000000193.2 ENSMUST00000000193.3 ENSMUST00000000193.4 ENSMUST00000000193.5 NM_011333 Q5SVU3 Q5SVU3_MOUSE uc007kmp.1 uc007kmp.2 uc007kmp.3 This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK150937.1, AK153520.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Secreted Belongs to the intercrine beta (chemokine CC) family. response to hypoxia positive regulation of leukocyte mediated cytotoxicity positive regulation of endothelial cell proliferation leukocyte migration involved in inflammatory response chronic inflammatory response positive regulation of leukocyte migration positive regulation of cellular extravasation cytokine activity extracellular region extracellular space cytoplasm rough endoplasmic reticulum cellular calcium ion homeostasis chemotaxis inflammatory response immune response transforming growth factor beta receptor signaling pathway aging chemokine activity heparin binding glial cell migration response to heat response to mechanical stimulus response to gamma radiation positive regulation of macrophage chemotaxis response to activity cytokine-mediated signaling pathway positive regulation of cell-cell adhesion endocytic vesicle dendrite neutrophil chemotaxis animal organ regeneration response to lipopolysaccharide response to progesterone positive regulation of tumor necrosis factor production cellular response to insulin stimulus positive regulation of collagen biosynthetic process response to vitamin B3 response to tumor necrosis factor cellular response to drug cellular response to macrophage colony-stimulating factor stimulus cellular response to platelet-derived growth factor stimulus response to drug neuronal cell body response to amino acid perikaryon axon terminus C-fiber synapse response to ethanol positive regulation of cell adhesion response to antibiotic vascular endothelial growth factor receptor signaling pathway macrophage chemotaxis lymphocyte chemotaxis perinuclear region of cytoplasm positive regulation of synaptic transmission response to glucocorticoid maternal process involved in female pregnancy maternal process involved in parturition chemokine-mediated signaling pathway cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to ATP cellular response to glucose stimulus cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to estradiol stimulus cellular response to fatty acid cellular response to lipoprotein particle stimulus cellular response to high density lipoprotein particle stimulus cellular response to dexamethasone stimulus positive regulation of monocyte chemotaxis positive regulation of wound healing positive regulation of protein targeting to membrane positive regulation of NMDA glutamate receptor activity response to cyclosporin A uc007kmp.1 uc007kmp.2 uc007kmp.3 
ENSMUST00000000194.4 Ccl12 ENSMUST00000000194.4 C-C motif chemokine ligand 12 (from RefSeq NM_011331.3) CCL12_MOUSE ENSMUST00000000194.1 ENSMUST00000000194.2 ENSMUST00000000194.3 Mcp5 NM_011331 Q62401 Q9QYD6 Scya12 uc007kms.1 uc007kms.2 uc007kms.3 Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation. Homodimer. Secreted. Predominantly expressed in the lymph nodes and thymus. Also found in the salivary glands containing lymph nodes, breast, heart, lung, brain, small intestine, kidney and colon. By interferon gamma and lipopolysaccharides (LPS). The polymorphism in strain SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease. Belongs to the intercrine beta (chemokine CC) family. MAPK cascade angiogenesis monocyte chemotaxis positive regulation of leukocyte migration cytokine activity extracellular region extracellular space chemotaxis inflammatory response immune response cytoskeleton organization G-protein coupled receptor signaling pathway chemokine activity regulation of cell shape cytokine-mediated signaling pathway neutrophil chemotaxis lipopolysaccharide-mediated signaling pathway CCR2 chemokine receptor binding negative regulation of glial cell apoptotic process protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of GTPase activity astrocyte cell migration CCR chemokine receptor binding eosinophil chemotaxis macrophage chemotaxis lymphocyte chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of leukocyte proliferation cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to organic cyclic compound positive regulation of calcium ion import negative regulation of vascular endothelial cell proliferation negative regulation of G1/S transition of mitotic cell cycle positive regulation of endothelial cell apoptotic process negative regulation of natural killer cell chemotaxis uc007kms.1 uc007kms.2 uc007kms.3 
ENSMUST00000000199.8 Ncs1 ENSMUST00000000199.8 neuronal calcium sensor 1 (from RefSeq NM_019681.3) A2AJ84 ENSMUST00000000199.1 ENSMUST00000000199.2 ENSMUST00000000199.3 ENSMUST00000000199.4 ENSMUST00000000199.5 ENSMUST00000000199.6 ENSMUST00000000199.7 Freq NCS1_MOUSE NM_019681 Q8BNY6 uc008jdq.1 uc008jdq.2 uc008jdq.3 uc008jdq.4 Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage- gated calcium channel (By similarity). Monomer (By similarity). Interacts with KCND2 (By similarity). Interacts in a calcium-independent manner with PI4KB (By similarity). This binding competes with CALN2/CABP7 binding to PI4KB (By similarity). Interacts in a calcium-dependent manner with PICK1 (via AH domain) (By similarity). Interacts with ARF1, ARF3, ARF5 and ARF6 (By similarity). Interacts with IL1RAPL1 (By similarity). Interacts with RIC8A; interaction is favored in the absence of Ca(2+) and myristoylation of NCS1 is not required (By similarity). Golgi apparatus Postsynaptic density Cytoplasm, perinuclear region Cytoplasm Cell membrane ; Peripheral membrane protein Membrane ipid-anchor Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. Binds 3 calcium ions via the second, third and fourth EF-hand. Belongs to the recoverin family. magnesium ion binding voltage-gated calcium channel activity calcium ion binding cytoplasm Golgi apparatus cytosol plasma membrane regulation of neuron projection development postsynaptic density membrane protein kinase binding cell junction axon dendrite dense core granule cytoplasmic vesicle intracellular membrane-bounded organelle calyx of Held synapse postsynaptic membrane positive regulation of exocytosis metal ion binding phosphatidylinositol-mediated signaling perinuclear region of cytoplasm positive regulation of synaptic transmission calcium ion transmembrane transport postsynapse glutamatergic synapse regulation of presynaptic cytosolic calcium ion concentration presynaptic cytosol postsynaptic cytosol voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels regulation of synaptic vesicle exocytosis uc008jdq.1 uc008jdq.2 uc008jdq.3 uc008jdq.4 
ENSMUST00000000201.7 Nalcn ENSMUST00000000201.7 sodium leak channel, non-selective (from RefSeq NM_177393.4) E9QLE4 E9QLE4_MOUSE ENSMUST00000000201.1 ENSMUST00000000201.2 ENSMUST00000000201.3 ENSMUST00000000201.4 ENSMUST00000000201.5 ENSMUST00000000201.6 NM_177393 Nalcn uc007vbq.1 uc007vbq.2 uc007vbq.3 ion channel activity cation channel activity ion transport membrane integral component of membrane ion transmembrane transport transmembrane transport cation transmembrane transport uc007vbq.1 uc007vbq.2 uc007vbq.3 
ENSMUST00000000206.4 Btbd17 ENSMUST00000000206.4 BTB domain containing 17 (from RefSeq NM_028055.4) BTBDH_MOUSE ENSMUST00000000206.1 ENSMUST00000000206.2 ENSMUST00000000206.3 NM_028055 Q9DB72 uc007mfr.1 uc007mfr.2 uc007mfr.3 Secreted molecular_function cellular_component extracellular region biological_process uc007mfr.1 uc007mfr.2 uc007mfr.3 
ENSMUST00000000208.13 Slfn4 ENSMUST00000000208.13 schlafen 4, transcript variant 1 (from RefSeq NM_011410.3) ENSMUST00000000208.1 ENSMUST00000000208.10 ENSMUST00000000208.11 ENSMUST00000000208.12 ENSMUST00000000208.2 ENSMUST00000000208.3 ENSMUST00000000208.4 ENSMUST00000000208.5 ENSMUST00000000208.6 ENSMUST00000000208.7 ENSMUST00000000208.8 ENSMUST00000000208.9 NM_011410 Q3UV66 Q3UV66_MOUSE Slfn4 uc007koj.1 uc007koj.2 The protein encoded by this gene belongs to the Schlafen family. All members of this family contain a Schlafen box domain that lies near an AAA domain. This protein belongs to the group 2 subset of Schlafen proteins, which are defined by a molecular weight between 58 kDa and 68 kDa and by the presence of a SWADL domain that contains the sequence Ser-Trp-Ala-Asp-Leu. In malignant melanoma cells, gene expression is up-regulated in response to interferon alpha. In bone marrow-derived macrophages, expression of this gene is induced during activation by Toll-like receptor agonists and repressed during macrophage colony-stimulating factor-mediated differentiation. Myelopoiesis is disrupted by constitutive overexpression in myeloid-lineage cells. A pseudogene of this gene is found on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. molecular_function cellular_component response to bacterium uc007koj.1 uc007koj.2 
ENSMUST00000000219.10 Th ENSMUST00000000219.10 tyrosine hydroxylase (from RefSeq NM_009377.2) ENSMUST00000000219.1 ENSMUST00000000219.2 ENSMUST00000000219.3 ENSMUST00000000219.4 ENSMUST00000000219.5 ENSMUST00000000219.6 ENSMUST00000000219.7 ENSMUST00000000219.8 ENSMUST00000000219.9 NM_009377 P24529 TY3H_MOUSE uc009koi.1 uc009koi.2 uc009koi.3 Catalyzes the conversion of L-tyrosine to L- dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (By similarity). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development(PubMed:30936473). Reaction=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa; Xref=Rhea:RHEA:18201, ChEBI:CHEBI:15379, ChEBI:CHEBI:15642, ChEBI:CHEBI:57504, ChEBI:CHEBI:58315, ChEBI:CHEBI:59560; EC=1.14.16.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18202; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Inhibited in feedback fashion by the catecholamine neurotransmitters, especially by dopamine in competition with tetrahydrobiopterin. Phosphorylation of several Ser/Thr residues in the N-terminus regulates the catalytic activity. Ser-31 and Ser-40 are readily phosphorylated to activate the catalytic activity. A Cysteine modification induced by N-ethylmaleimide (NEM), inhibits tyrosine 3- monooxygenase activity through the modification of the Cys-177. Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2. Homotetramer. Interacts (when phosphorylated at Ser-19) with YWHAG; one YWHAG dimer bounds to one TH tetramer this interaction may influence the phosphorylation and dephosphorylation of other sites. Cytoplasm, perinuclear region Nucleus Cell projection, axon Cytoplasm Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Note=When phosphorylated at Ser-19 shows a nuclear distribution and when phsphorylated at Ser-31 as well at Ser-40 shows a cytosolic distribution (By similarity). Expressed in dopaminergic axons and axon terminals (PubMed:17296554). Expressed in the adrenal gland (PubMed:1674869). Expressed in the retina (PubMed:30936473). Expressed in the in the striatum (at protein level) (PubMed:17296554). Expressed in the retinal inner nuclear layer and outer nuclear layer at postnatal day 8 (P8) (PubMed:30936473). Expressed in retinal dopaminergic amacrine cells in the retina at P8 and P15 (PubMed:30936473). Phosphorylated on Ser-19, Ser-31 and Ser-40 by several protein kinases with different site specificities. Phosphorylation at Ser-31 and Ser-40 leads to an increase of TH activity. Phosphorylation at Ser- 40 activates the enzyme and also counteracts the feedback inhibition of TH by catecholamines (By similarity). Phosphorylation of Ser-19 and Ser-31 triggers the proteasomal degradation of TH through the ubiquitin-proteasome pathway (By similarity). Phosphorylation at Ser-31 facilitates transport of TH from the soma to the nerve terminals via the microtubule network (By similarity). Phosphorylation at Ser-19 induces the high-affinity binding to the 14-3-3 protein YWHAG; this interaction may influence the phosphorylation and dephosphorylation of other sites (By similarity). Ser-19 increases the phosphorylation at Ser-40 in a hierarchical manner, leading to increased activity (By similarity). Homozygotes deficient mice are deficient in catecholamines, and usually die around embryonic day 11.5-15.5 due to cardiac failure (PubMed:7715703). Increased number of persisting retinal hyaloid vessels due to loss of hyaloid vessel regression at P8 (PubMed:30936473). Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. response to hypoxia synaptic transmission, dopaminergic response to amphetamine monooxygenase activity tyrosine 3-monooxygenase activity iron ion binding nucleus cytoplasm mitochondrion smooth endoplasmic reticulum cytosol dopamine biosynthetic process from tyrosine fatty acid metabolic process sphingolipid metabolic process heart development visual perception sensory perception of sound learning memory mating behavior locomotory behavior regulation of heart contraction synaptic vesicle ferrous iron binding ferric iron binding aromatic amino acid family metabolic process response to water deprivation response to light stimulus response to herbicide response to salt stress animal organ morphogenesis cytoplasmic side of plasma membrane response to metal ion response to zinc ion multicellular organism aging response to organic cyclic compound response to activity aminergic neurotransmitter loading into synaptic vesicle glycoside metabolic process oxidoreductase activity amino acid binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen response to insecticide phthalate metabolic process oxygen binding enzyme binding protein domain specific binding cerebral cortex development axon dendrite cytoplasmic vesicle membrane cytoplasmic vesicle response to nutrient levels response to estradiol response to lipopolysaccharide isoquinoline alkaloid metabolic process melanosome membrane tetrahydrobiopterin binding response to nicotine social behavior dopamine binding cellular response to drug response to isolation stress response to immobilization stress neurotransmitter biosynthetic process terpene metabolic process dopamine biosynthetic process epinephrine biosynthetic process norepinephrine biosynthetic process catecholamine biosynthetic process eye photoreceptor cell development response to drug circadian sleep/wake cycle eating behavior neuron projection neuronal cell body terminal bouton perikaryon response to peptide hormone response to ethanol response to ether response to pyrethroid metal ion binding response to steroid hormone embryonic camera-type eye morphogenesis cognition response to corticosterone response to electrical stimulus phytoalexin metabolic process oxidation-reduction process response to growth factor cellular response to manganese ion cellular response to alkaloid cellular response to nicotine cellular response to glucose stimulus cellular response to growth factor stimulus uc009koi.1 uc009koi.2 uc009koi.3 
ENSMUST00000000221.6 Scnn1g ENSMUST00000000221.6 sodium channel, nonvoltage-gated 1 gamma (from RefSeq NM_011326.3) ENSMUST00000000221.1 ENSMUST00000000221.2 ENSMUST00000000221.3 ENSMUST00000000221.4 ENSMUST00000000221.5 NM_011326 Q9WU39 SCNNG_MOUSE uc009jnv.1 uc009jnv.2 uc009jnv.3 uc009jnv.4 This gene encodes the gamma subunit of the epithelial sodium channel, a member of the amiloride-sensitive sodium channel family of proteins. This channel regulates sodium homeostasis and blood pressure, by controlling sodium transport in the kidney, colon and lung. Proteolytic processing of the encoded protein results in the release of an inhibitory peptide and channel activation. Homozygous knockout mice for this gene exhibit perinatal lethality, likely due to excess serum potassium. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021338.1, AF112187.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849387 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Activated by WNK1, WNK2, WNK3 and WNK4. Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties (Probable). Interacts with NEDD4; via the WW domains (PubMed:11244092, PubMed:15123669). Interacts with NEDD4L; via the WW domains (PubMed:12424229, PubMed:11244092, PubMed:15123669). Interacts with WWP1; via the WW domains (By similarity). Interacts with WWP2; via the WW domains. Interacts with the full-length immature form of PCSK9 (pro-PCSK9) (By similarity). Apical cell membrane ; Multi-pass membrane protein Note=Apical membrane of epithelial cells. Lung and kidney. ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation. Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily. ion channel activity sodium channel activity nucleoplasm plasma membrane integral component of plasma membrane ion transport sodium ion transport external side of plasma membrane cell surface ligand-gated sodium channel activity membrane integral component of membrane apical plasma membrane sodium channel complex wound healing, spreading of epidermal cells sodium ion transmembrane transport WW domain binding multicellular organismal water homeostasis response to stimulus sensory perception of taste sodium ion homeostasis extracellular exosome uc009jnv.1 uc009jnv.2 uc009jnv.3 uc009jnv.4 
ENSMUST00000000253.6 Lhx2 ENSMUST00000000253.6 LIM homeobox protein 2, transcript variant 1 (from RefSeq NM_010710.5) ENSMUST00000000253.1 ENSMUST00000000253.2 ENSMUST00000000253.3 ENSMUST00000000253.4 ENSMUST00000000253.5 LHX2_MOUSE NM_010710 Q9Z0S2 uc008jnl.1 uc008jnl.2 uc008jnl.3 uc008jnl.4 Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types. Interacts (via LIM domains) with CITED2 (PubMed:10593900). Interacts with POU4F2 isoform 1 (PubMed:24643061). Nucleus LIM domains are necessary for transcription activation. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding neural tube closure hair follicle development DNA binding chromatin binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated nervous system development axon guidance brain development mesoderm development transcription factor binding dorsal/ventral pattern formation telencephalon development olfactory bulb development telencephalon regionalization cerebral cortex development neurogenesis neuron differentiation sequence-specific DNA binding maintenance of epithelial cell apical/basal polarity negative regulation of gene expression, epigenetic positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding anatomical structure formation involved in morphogenesis axon extension negative regulation of neurogenesis retina development in camera-type eye positive regulation of neural precursor cell proliferation negative regulation of transcription regulatory region DNA binding uc008jnl.1 uc008jnl.2 uc008jnl.3 uc008jnl.4 
ENSMUST00000000254.14 Clec2g ENSMUST00000000254.14 C-type lectin domain family 2, member g, transcript variant 1 (from RefSeq NM_027562.4) CLC2G_MOUSE Clec2f Ddv10 ENSMUST00000000254.1 ENSMUST00000000254.10 ENSMUST00000000254.11 ENSMUST00000000254.12 ENSMUST00000000254.13 ENSMUST00000000254.2 ENSMUST00000000254.3 ENSMUST00000000254.4 ENSMUST00000000254.5 ENSMUST00000000254.6 ENSMUST00000000254.7 ENSMUST00000000254.8 ENSMUST00000000254.9 NM_027562 Ocilrp1 Q1AFZ6 Q3UUY2 Q80Z35 Q8BHH6 Q9D676 uc009eew.1 uc009eew.2 uc009eew.3 uc009eew.4 Inhibits osteoclast formation. Cell membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D676-1; Sequence=Displayed; Name=2; IsoId=Q9D676-2; Sequence=VSP_030529; Detected in vagina, eye, tongue, stomach and spleen. Constitutively expressed in bone marrow cells. Up-regulated in vagina after 17-beta-estradiol treatment. Down-regulated after removal of ovaries. extracellular space plasma membrane membrane integral component of membrane carbohydrate binding negative regulation of osteoclast differentiation natural killer cell lectin-like receptor binding uc009eew.1 uc009eew.2 uc009eew.3 uc009eew.4 
ENSMUST00000000260.13 Gmpr ENSMUST00000000260.13 guanosine monophosphate reductase (from RefSeq NM_025508.5) ENSMUST00000000260.1 ENSMUST00000000260.10 ENSMUST00000000260.11 ENSMUST00000000260.12 ENSMUST00000000260.2 ENSMUST00000000260.3 ENSMUST00000000260.4 ENSMUST00000000260.5 ENSMUST00000000260.6 ENSMUST00000000260.7 ENSMUST00000000260.8 ENSMUST00000000260.9 GMPR1_MOUSE Gmpr1 NM_025508 Q9DCZ1 uc007qha.1 uc007qha.2 uc007qha.3 uc007qha.4 A similar gene in human encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. [provided by RefSeq, May 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK009159.1, AK002326.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Reaction=IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH; Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115, ChEBI:CHEBI:58349; EC=1.7.1.7; Evidence= Homotetramer. Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. catalytic activity GMP reductase activity purine nucleobase metabolic process purine nucleotide metabolic process nucleotide metabolic process purine ribonucleotide interconversion oxidoreductase activity metal ion binding oxidation-reduction process GMP reductase complex uc007qha.1 uc007qha.2 uc007qha.3 uc007qha.4 
ENSMUST00000000266.9 Ifi202b ENSMUST00000000266.9 interferon activated gene 202B, transcript variant 2 (from RefSeq NM_011940.2) E9QLD9 ENSMUST00000000266.1 ENSMUST00000000266.2 ENSMUST00000000266.3 ENSMUST00000000266.4 ENSMUST00000000266.5 ENSMUST00000000266.6 ENSMUST00000000266.7 ENSMUST00000000266.8 IFI2_MOUSE Ifi202 Ifi202a Ifi202b NM_011940 P15091 Q38JF1 Q7TMN6 Q8VEL7 Q9R002 uc011wwx.1 uc011wwx.2 uc011wwx.3 DNA-binding protein involved in innate immune response and has anti-inflammatory activity (PubMed:19131592, PubMed:23850291, PubMed:23567559). Inhibits caspase activation in response to cytosolic DNA by preventing activation of the AIM2 inflammasome, probably by sequestering cytoplasmic DNA and preventing its being bound by AIM2 (PubMed:19131592, PubMed:23850291, PubMed:23567559). Also inhibits activation of the AIM2 inflammasome via a direct interaction with AIM2, which prevents the interaction between AIM2 and PYCARD and formation of the AIM2 inflammasome (PubMed:23850291). Binds double-stranded DNA (dsDNA) in the cytosol (PubMed:19131592, PubMed:23850291, PubMed:23567559, PubMed:24419611). Has anti-apoptotic effects due to inhibition of the transcriptional activity of TP53/p53 (PubMed:16670293). Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin (PubMed:8524315). Homomultimer; homotetramerizes (via HIN-200 domain 2), enhancing affinity for double-stranded DNA (dsDNA) (PubMed:9821952, PubMed:23850291). Interacts (via HIN-200 domain 2) with AIM2 (via HIN- 200 domain); preventing activation of the AIM2 inflammasome (PubMed:23850291). Binds to several transcription factors, including NF-kappa-B p50 (NFKB1) and p65 (RELA), FOS, JUN, E2F1, E2F4, MYOD1 and myogenin (PubMed:8524315). Also binds TP53/p53, the hypophosphorylated, growth-inhibitory form of the retinoblastoma protein and the p53- binding protein 1 (TP53BP1) (PubMed:8910340, PubMed:16670293). Q9R002; P13405: Rb1; NbExp=7; IntAct=EBI-3043899, EBI-971782; Q9R002; P06400: RB1; Xeno; NbExp=5; IntAct=EBI-3043899, EBI-491274; Cytoplasm cleus Note=Accumulates first in the cytoplasm, and is translocated to the nucleus after a delay, where it is primarily chromatin-associated. By beta interferon (PubMed:2477366, PubMed:14764608). By IL6 in splenocytes (at protein level) (PubMed:14764608). The HIN-200 domain 1 mediates non-specific double-stranded DNA (dsDNA)-binding via electrostatic interactions: it recognizes both strands of DNA (PubMed:23567559, PubMed:24419611). The HIN-200 domain 2 mediates homotetramerization and interaction with AIM2 (PubMed:23850291). Phosphorylated. NZB mice express 10 to 100 fold more Ifi202 in spleen than B6 or NZW mice (PubMed:11567633). This could account for the high susceptibility of NZB mice to systemic lupus (PubMed:11567633). Belongs to the HIN-200 family. activation of innate immune response immune system process DNA binding double-stranded DNA binding protein binding nucleus nucleolus cytoplasm inflammatory response response to bacterium positive regulation of interleukin-1 beta production cellular response to interferon-beta negative regulation of cysteine-type endopeptidase activity involved in apoptotic process innate immune response negative regulation of innate immune response uc011wwx.1 uc011wwx.2 uc011wwx.3 
ENSMUST00000000275.10 Glra3 ENSMUST00000000275.10 glycine receptor, alpha 3 subunit, transcript variant 1 (from RefSeq NM_080438.4) ENSMUST00000000275.1 ENSMUST00000000275.2 ENSMUST00000000275.3 ENSMUST00000000275.4 ENSMUST00000000275.5 ENSMUST00000000275.6 ENSMUST00000000275.7 ENSMUST00000000275.8 ENSMUST00000000275.9 GLRA3_MOUSE NM_080438 Q7TSQ2 Q91XP5 uc009lsn.1 uc009lsn.2 uc009lsn.3 Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:15131310, PubMed:20978350). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:15131310). Contributes to increased pain perception in response to increased prostaglandin E2 levels (PubMed:15131310). Plays a role in the regulation of breathing rhythm, especially of the duration of the postinspiratory phase (PubMed:20978350). Plays a role in cellular responses to ethanol (By similarity). Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence= Inhibited by prostaglandin E2, probably via PKA- mediated phosphorylation at Ser-379 (PubMed:15131310). Homopentamer (in vitro) (By similarity). Heteropentamer composed of GLRA3 and GLRB. Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different (By similarity). Postsynaptic cell membrane ulti-pass membrane protein Synapse rikaryon Cell projection, dendrite Cell membrane ; Multi-pass membrane protein Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes. Detected in brainstem, also in neurons that control rhythmic breathing (PubMed:20978350). Detected in superficial laminae of the dorsal horn of the thoracic spinal cord (PubMed:15131310). Detected in dentate gyrus in hippocampus, especially in stratum granulare (PubMed:19723286). Detected in the inner plexiform layer in the retina (at protein level) (PubMed:12975813). Detected in midbrain, thalamus, brain cortex, hippocampus, and at lower levels in cerebellum (PubMed:19723286). The N-terminal domain carries structural determinants essential for agonist and antagonist binding. The channel pore is formed by pentameric assembly of the second transmembrane domain from all five subunits. The cytoplasmic loop is an important determinant of channel inactivation kinetics. Phosphorylated by PKA; this causes down-regulation of channel activity. Dephosphorylated in response to activation of HTR1A signaling; this increases channel activity (PubMed:20978350). Mutant mice are born at the expected Mendelian rate, appear normal and are fertile. They do not display notable alterations in motor coordination and startle response, or other neuromotor defects. Glycinergic postsynaptic inhibitory currents in spinal cord appear unchanged, but are not inhibited by prostaglandin E2, contrary to what is observed with wild-type. Basal nociception is unchanged, but contrary to wild-type, mutant mice do not display increased sensitivity to pain after prostaglandin E2 injection. Likewise, they show a more rapid decrease of the increased pain sensitivity caused by agents that cause local inflammation, such as subcutaneous zymosan injection (PubMed:15131310). Mutant mice display altered phrenic nerve activity, resulting in an irregular breathing rhythm that affects especially the duration of the postinspiratory phase. Contrary to wild-type, their respiratory rhythm is not accelerated by serotonin (PubMed:20978350). The alpha subunit binds strychnine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction neuropeptide signaling pathway chemical synaptic transmission membrane integral component of membrane glycine binding extracellular-glycine-gated chloride channel activity glycine-gated chloride channel complex transmitter-gated ion channel activity glycine-gated chloride ion channel activity cell junction dendrite ion transmembrane transport chloride channel complex regulation of membrane potential cell projection neuron projection response to amino acid perikaryon synapse postsynaptic membrane metal ion binding neurological system process protein homooligomerization synaptic transmission, glycinergic excitatory postsynaptic potential cellular response to amino acid stimulus cellular response to zinc ion cellular response to ethanol glutamate receptor clustering glutamatergic synapse GABA-ergic synapse integral component of postsynaptic specialization membrane chloride transmembrane transport regulation of synaptic vesicle exocytosis uc009lsn.1 uc009lsn.2 uc009lsn.3 
ENSMUST00000000287.9 Scpep1 ENSMUST00000000287.9 serine carboxypeptidase 1 (from RefSeq NM_029023.3) ENSMUST00000000287.1 ENSMUST00000000287.2 ENSMUST00000000287.3 ENSMUST00000000287.4 ENSMUST00000000287.5 ENSMUST00000000287.6 ENSMUST00000000287.7 ENSMUST00000000287.8 NM_029023 Q920A5 Q9D625 RISC_MOUSE Risc uc007kvx.1 uc007kvx.2 uc007kvx.3 uc007kvx.4 May be involved in vascular wall and kidney homeostasis. Secreted Belongs to the peptidase S10 family. carboxypeptidase activity serine-type carboxypeptidase activity extracellular region cytosol proteolysis peptidase activity hydrolase activity retinoic acid metabolic process negative regulation of blood pressure proteolysis involved in cellular protein catabolic process uc007kvx.1 uc007kvx.2 uc007kvx.3 uc007kvx.4 
ENSMUST00000000291.9 Mnt ENSMUST00000000291.9 max binding protein (from RefSeq NM_010813.3) ENSMUST00000000291.1 ENSMUST00000000291.2 ENSMUST00000000291.3 ENSMUST00000000291.4 ENSMUST00000000291.5 ENSMUST00000000291.6 ENSMUST00000000291.7 ENSMUST00000000291.8 MNT_MOUSE NM_010813 O08789 P97349 Q6GTJ3 Rox uc011xzb.1 uc011xzb.2 uc011xzb.3 Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX. Nucleus. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated cell aging protein dimerization activity regulation of cell cycle negative regulation of apoptotic signaling pathway uc011xzb.1 uc011xzb.2 uc011xzb.3 
ENSMUST00000000299.14 Itgb2 ENSMUST00000000299.14 integrin beta 2, transcript variant 1 (from RefSeq NM_008404.5) ENSMUST00000000299.1 ENSMUST00000000299.10 ENSMUST00000000299.11 ENSMUST00000000299.12 ENSMUST00000000299.13 ENSMUST00000000299.2 ENSMUST00000000299.3 ENSMUST00000000299.4 ENSMUST00000000299.5 ENSMUST00000000299.6 ENSMUST00000000299.7 ENSMUST00000000299.8 ENSMUST00000000299.9 Itgb2 NM_008404 Q542I8 Q542I8_MOUSE uc007fvv.1 uc007fvv.2 uc007fvv.3 Cell membrane ingle-pass type I membrane protein Membrane raft ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the integrin beta chain family. leukocyte migration involved in inflammatory response plasma membrane cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion integrin-mediated signaling pathway aging integrin complex cell surface membrane integral component of membrane natural killer cell activation signaling receptor activity endothelial cell migration macromolecular complex binding cellular extravasation positive regulation of nitric oxide biosynthetic process positive regulation of angiogenesis protein heterodimerization activity cell adhesion molecule binding positive regulation of NF-kappaB transcription factor activity cell-cell adhesion uc007fvv.1 uc007fvv.2 uc007fvv.3 
ENSMUST00000000304.14 Hddc2 ENSMUST00000000304.14 HD domain containing 2, transcript variant 8 (from RefSeq NR_184419.1) ENSMUST00000000304.1 ENSMUST00000000304.10 ENSMUST00000000304.11 ENSMUST00000000304.12 ENSMUST00000000304.13 ENSMUST00000000304.2 ENSMUST00000000304.3 ENSMUST00000000304.4 ENSMUST00000000304.5 ENSMUST00000000304.6 ENSMUST00000000304.7 ENSMUST00000000304.8 ENSMUST00000000304.9 HDDC2_MOUSE NR_184419 Q3SXD3 Q9CV20 uc007etq.1 uc007etq.2 uc007etq.3 Catalyzes the dephosphorylation of the nucleoside 5'- monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP). Reaction=a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'- deoxyribonucleoside + phosphate; Xref=Rhea:RHEA:36167, ChEBI:CHEBI:15377, ChEBI:CHEBI:18274, ChEBI:CHEBI:43474, ChEBI:CHEBI:65317; EC=3.1.3.89; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 divalent metal cations (By similarity). Shows activity with Mn(2+), Co(2+) and Mg(2+) but shows no activity with Zn(2+) (By similarity). Homodimer. Belongs to the HDDC2 family. mitochondrion dephosphorylation uc007etq.1 uc007etq.2 uc007etq.3 
ENSMUST00000000305.7 Tpd52l1 ENSMUST00000000305.7 tumor protein D52-like 1, transcript variant 2 (from RefSeq NM_009413.2) ENSMUST00000000305.1 ENSMUST00000000305.2 ENSMUST00000000305.3 ENSMUST00000000305.4 ENSMUST00000000305.5 ENSMUST00000000305.6 NM_009413 O54818 TPD53_MOUSE uc007ets.1 uc007ets.2 uc007ets.3 Forms a homodimer or heterodimer with other members of the family. Belongs to the TPD52 family. G2/M transition of mitotic cell cycle cytoplasm early endosome identical protein binding protein homodimerization activity positive regulation of MAP kinase activity positive regulation of JNK cascade protein heterodimerization activity perinuclear region of cytoplasm positive regulation of apoptotic signaling pathway uc007ets.1 uc007ets.2 uc007ets.3 
ENSMUST00000000310.14 Pemt ENSMUST00000000310.14 phosphatidylethanolamine N-methyltransferase, transcript variant 4 (from RefSeq NM_001290013.1) ENSMUST00000000310.1 ENSMUST00000000310.10 ENSMUST00000000310.11 ENSMUST00000000310.12 ENSMUST00000000310.13 ENSMUST00000000310.2 ENSMUST00000000310.3 ENSMUST00000000310.4 ENSMUST00000000310.5 ENSMUST00000000310.6 ENSMUST00000000310.7 ENSMUST00000000310.8 ENSMUST00000000310.9 NM_001290013 PEMT_MOUSE Pempt Pemt Pemt2 Q3UZN8 Q61907 Q7TNW6 Q8R0I1 uc056yld.1 uc056yld.2 uc056yld.3 Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure (PubMed:9371769) (Probable). Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N- methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step (PubMed:9371769). Reaction=1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S- adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N- dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:32735, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64572, ChEBI:CHEBI:64573; EC=2.1.1.71; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32736; Evidence=; Reaction=1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S- adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:32739, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64572; EC=2.1.1.71; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32740; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L- methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:11164, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64573, ChEBI:CHEBI:64612; EC=2.1.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11165; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S- adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:70619, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74986, ChEBI:CHEBI:85679; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70620; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N- methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:46112, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:85679, ChEBI:CHEBI:85680; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46113; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N- dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:70623, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74669, ChEBI:CHEBI:85680; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70624; Evidence=; Reaction=1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:70739, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:172403, ChEBI:CHEBI:189848; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70740; Evidence=; Reaction=1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N- methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:70743, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:189848, ChEBI:CHEBI:189849; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70744; Evidence=; Reaction=1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N- dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:70747, ChEBI:CHEBI:15378, ChEBI:CHEBI:42027, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:189849; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70748; Evidence=; Reaction=1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3- phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z- octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:70751, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:189858, ChEBI:CHEBI:189859; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70752; Evidence=; Reaction=1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N- methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z- octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:70755, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:189859, ChEBI:CHEBI:189860; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70756; Evidence=; Reaction=1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N- dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z- octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:70759, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:86161, ChEBI:CHEBI:189860; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70760; Evidence=; Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1- hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3- phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:70763, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:78261, ChEBI:CHEBI:189861; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70764; Evidence=; Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1- hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3- phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:70767, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:189861, ChEBI:CHEBI:189862; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70768; Evidence=; Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:70771, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74963, ChEBI:CHEBI:189862; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70772; Evidence=; Phospholipid metabolism; phosphatidylcholine biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61907-1; Sequence=Displayed; Name=2; IsoId=Q61907-2; Sequence=VSP_053224; Expressed in liver (at protein level). Severe liver pathology rapidly occurs in knockout mice after 3-days withdrawal of dietary choline, which might occur during starvation, pregnancy or lactation, and may die after 4-5 days (PubMed:9765216). Homocysteine plasma content in knockouts is 50 percent less of the content in wild type mice (PubMed:12482759). Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. Sequence=AAQ01190.1; Type=Frameshift; Evidence=; phosphatidyl-N-methylethanolamine N-methyltransferase activity blastocyst hatching phosphatidylethanolamine N-methyltransferase activity mitochondrion mitochondrial envelope endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process glycerophospholipid metabolic process phosphatidylcholine biosynthetic process sphingomyelin biosynthetic process methyltransferase activity negative regulation of cell proliferation phosphatidylethanolamine binding phospholipid biosynthetic process S-adenosylmethionine-dependent methyltransferase activity membrane integral component of membrane transferase activity brush border membrane mitochondrial membrane methylation response to vitamin sarcolemma response to drug S-adenosylhomocysteine metabolic process S-adenosylmethionine metabolic process positive regulation of lipoprotein metabolic process phosphatidyl-N-dimethylethanolamine N-methyltransferase activity uc056yld.1 uc056yld.2 uc056yld.3 
ENSMUST00000000312.12 Cdh1 ENSMUST00000000312.12 cadherin 1 (from RefSeq NM_009864.3) A0A0R4IZW5 A0A0R4IZW5_MOUSE Cdh1 ENSMUST00000000312.1 ENSMUST00000000312.10 ENSMUST00000000312.11 ENSMUST00000000312.2 ENSMUST00000000312.3 ENSMUST00000000312.4 ENSMUST00000000312.5 ENSMUST00000000312.6 ENSMUST00000000312.7 ENSMUST00000000312.8 ENSMUST00000000312.9 NM_009864 uc009ngi.1 uc009ngi.2 uc009ngi.3 uc009ngi.4 This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related cadherin gene on chromosome 8. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK076369.1, X06115.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cadherins are calcium-dependent cell adhesion proteins. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. Cell membrane ingle-pass type I membrane protein Golgi apparatus, trans-Golgi network Membrane ; Single-pass type I membrane protein calcium ion binding cytoplasm trans-Golgi network plasma membrane cell-cell adherens junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly beta-catenin binding response to toxic substance cytoplasmic side of plasma membrane response to organic substance regulation of gene expression actin cytoskeleton membrane integral component of membrane lateral plasma membrane catenin complex flotillin complex pituitary gland development negative regulation of cell-cell adhesion lamellipodium cell junction negative regulation of cell migration ankyrin binding cortical actin cytoskeleton neuron projection development GTPase activating protein binding adherens junction organization positive regulation of protein import into nucleus response to drug identical protein binding apical junction complex gamma-catenin binding positive regulation of transcription, DNA-templated perinuclear region of cytoplasm cell adhesion molecule binding cellular response to lithium ion cellular response to indole-3-methanol protein localization to plasma membrane cell-cell adhesion postsynapse glutamatergic synapse regulation of protein catabolic process at postsynapse, modulating synaptic transmission uc009ngi.1 uc009ngi.2 uc009ngi.3 uc009ngi.4 
ENSMUST00000000314.13 Cdh4 ENSMUST00000000314.13 cadherin 4, transcript variant 1 (from RefSeq NM_009867.4) CADH4_MOUSE ENSMUST00000000314.1 ENSMUST00000000314.10 ENSMUST00000000314.11 ENSMUST00000000314.12 ENSMUST00000000314.2 ENSMUST00000000314.3 ENSMUST00000000314.4 ENSMUST00000000314.5 ENSMUST00000000314.6 ENSMUST00000000314.7 ENSMUST00000000314.8 ENSMUST00000000314.9 NM_009867 P39038 uc008ohv.1 uc008ohv.2 uc008ohv.3 uc008ohv.4 uc008ohv.5 This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. The encoded protein is involved in retinal angiogenesis during development where it plays a crucial role in the endothelial-astrocyte interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. Cell membrane; Single-pass type I membrane protein. Distributed widely in mouse tissues with high levels present in brain, skeletal muscle and thymus. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. cell morphogenesis calcium ion binding plasma membrane integral component of plasma membrane cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules axon guidance cytoskeletal protein binding cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex adherens junction organization protein homodimerization activity cell-cell adhesion mediated by cadherin cadherin binding positive regulation of axon extension metal ion binding cell-cell adhesion uc008ohv.1 uc008ohv.2 uc008ohv.3 uc008ohv.4 uc008ohv.5 
ENSMUST00000000326.12 Bcl6b ENSMUST00000000326.12 B cell CLL/lymphoma 6, member B (from RefSeq NM_007528.3) Bcl6b ENSMUST00000000326.1 ENSMUST00000000326.10 ENSMUST00000000326.11 ENSMUST00000000326.2 ENSMUST00000000326.3 ENSMUST00000000326.4 ENSMUST00000000326.5 ENSMUST00000000326.6 ENSMUST00000000326.7 ENSMUST00000000326.8 ENSMUST00000000326.9 NM_007528 Q5BKP3 Q5BKP3_MOUSE uc007juc.1 uc007juc.2 uc007juc.3 uc007juc.4 Nucleus nucleic acid binding uc007juc.1 uc007juc.2 uc007juc.3 uc007juc.4 
ENSMUST00000000327.13 Clec10a ENSMUST00000000327.13 C-type lectin domain family 10, member A, transcript variant 1 (from RefSeq NM_001204252.1) Clec10a ENSMUST00000000327.1 ENSMUST00000000327.10 ENSMUST00000000327.11 ENSMUST00000000327.12 ENSMUST00000000327.2 ENSMUST00000000327.3 ENSMUST00000000327.4 ENSMUST00000000327.5 ENSMUST00000000327.6 ENSMUST00000000327.7 ENSMUST00000000327.8 ENSMUST00000000327.9 F8WHB7 F8WHB7_MOUSE NM_001204252 uc007jty.1 uc007jty.2 uc007jty.3 uc007jty.4 membrane integral component of membrane carbohydrate binding uc007jty.1 uc007jty.2 uc007jty.3 uc007jty.4 
ENSMUST00000000329.9 Alox12 ENSMUST00000000329.9 arachidonate 12-lipoxygenase, transcript variant 1 (from RefSeq NM_007440.5) Alox12p ENSMUST00000000329.1 ENSMUST00000000329.2 ENSMUST00000000329.3 ENSMUST00000000329.4 ENSMUST00000000329.5 ENSMUST00000000329.6 ENSMUST00000000329.7 ENSMUST00000000329.8 LOX12_MOUSE NM_007440 P39655 Q8BHG4 uc007juj.1 uc007juj.2 uc007juj.3 Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:8188678, PubMed:11256953, PubMed:25293588). Mainly converts arachidonate ((5Z,8Z,11Z,14Z)- eicosatetraenoate) to the specific bioactive lipid (12S)- hydroperoxyeicosatetraenoate/(12S)-HPETE (PubMed:8188678, PubMed:11256953). Through the production of bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation (PubMed:9501222). It can also catalyze the epoxidation of double bonds of polyunsaturated fatty acids such as (14S)-hydroperoxy-docosahexaenoate/(14S)-HPDHA resulting in the formation of (13S,14S)-epoxy-DHA. Furthermore, it may participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)- docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets (By similarity). An additional function involves a multistep process by which it transforms leukotriene A4/LTA4 into the bioactive lipids lipoxin A4/LXA4 and lipoxin B4/LXB4, both are vasoactive and LXA4 may regulate neutrophil function via occupancy of specific recognition sites (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to (13S)- hydroperoxyoctadecadienoate/ (13S-HPODE) (PubMed:11256953). Due to its role in regulating both the expression of the vascular endothelial growth factor (VEGF, an angiogenic factor involved in the survival and metastasis of solid tumors) and the expression of integrin beta-1 (known to affect tumor cell migration and proliferation), it can be regarded as protumorigenic. Important for cell survival, as it may play a role not only in proliferation but also in the prevention of apoptosis in vascular smooth muscle cells (By similarity). Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy- (5Z,8Z,10E,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:10428, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57444; EC=1.13.11.31; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10429; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)- octadecadienoate; Xref=Rhea:RHEA:22780, ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:57466; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22781; Evidence=; Reaction=2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin A4; Xref=Rhea:RHEA:48584, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57463, ChEBI:CHEBI:67026; Evidence=; Reaction=2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin B4; Xref=Rhea:RHEA:48588, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57463, ChEBI:CHEBI:67031; Evidence=; Reaction=(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy- (5Z,8Z,10E)-eicosatrienoate; Xref=Rhea:RHEA:41324, ChEBI:CHEBI:15379, ChEBI:CHEBI:78043, ChEBI:CHEBI:78046; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41325; Evidence=; Reaction=(8Z,11Z,14Z)-eicosatrienoate + O2 = (12S)-hydroperoxy- (8Z,10E,14Z)-eicosatrienoate; Xref=Rhea:RHEA:41328, ChEBI:CHEBI:15379, ChEBI:CHEBI:71589, ChEBI:CHEBI:78047; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41329; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)- hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate; Xref=Rhea:RHEA:41332, ChEBI:CHEBI:15379, ChEBI:CHEBI:77016, ChEBI:CHEBI:78048; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41333; Evidence=; Reaction=(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate; Xref=Rhea:RHEA:64724, ChEBI:CHEBI:15379, ChEBI:CHEBI:156049, ChEBI:CHEBI:156082; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64725; Evidence=; Reaction=(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate; Xref=Rhea:RHEA:64728, ChEBI:CHEBI:15379, ChEBI:CHEBI:140349, ChEBI:CHEBI:156049; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64729; Evidence=; Reaction=(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)- hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate; Xref=Rhea:RHEA:50276, ChEBI:CHEBI:15379, ChEBI:CHEBI:131965, ChEBI:CHEBI:132063; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50277; Evidence=; Reaction=(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)- hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate; Xref=Rhea:RHEA:50284, ChEBI:CHEBI:15379, ChEBI:CHEBI:131964, ChEBI:CHEBI:132065; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50285; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy- (5Z,8Z,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:16869, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57446; EC=1.13.11.33; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16870; Evidence=; Reaction=(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate = (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O; Xref=Rhea:RHEA:53532, ChEBI:CHEBI:15377, ChEBI:CHEBI:78048, ChEBI:CHEBI:131958; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53533; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(15S)- hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine; Xref=Rhea:RHEA:50184, ChEBI:CHEBI:15379, ChEBI:CHEBI:132071, ChEBI:CHEBI:132077; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50185; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(12S)- hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine; Xref=Rhea:RHEA:50172, ChEBI:CHEBI:15379, ChEBI:CHEBI:132071, ChEBI:CHEBI:132074; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50173; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma- aminobutanoate; Xref=Rhea:RHEA:50180, ChEBI:CHEBI:15379, ChEBI:CHEBI:132072, ChEBI:CHEBI:132078; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50181; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma- aminobutanoate; Xref=Rhea:RHEA:50176, ChEBI:CHEBI:15379, ChEBI:CHEBI:132072, ChEBI:CHEBI:132075; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50177; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)- hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine; Xref=Rhea:RHEA:50188, ChEBI:CHEBI:15379, ChEBI:CHEBI:59002, ChEBI:CHEBI:132076; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50189; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)- hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine; Xref=Rhea:RHEA:50168, ChEBI:CHEBI:15379, ChEBI:CHEBI:59002, ChEBI:CHEBI:132073; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50169; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(12S)- hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine; Xref=Rhea:RHEA:50160, ChEBI:CHEBI:15379, ChEBI:CHEBI:132060, ChEBI:CHEBI:132061; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50161; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)- hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine; Xref=Rhea:RHEA:50156, ChEBI:CHEBI:15379, ChEBI:CHEBI:132060, ChEBI:CHEBI:132062; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50157; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (12S)- hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate; Xref=Rhea:RHEA:48704, ChEBI:CHEBI:15379, ChEBI:CHEBI:58562, ChEBI:CHEBI:90772; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48705; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation per subunit.; Activated by EGF. Arachidonic acid conversion is inhibited by (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate (13S,14S-epoxy-DHA) (By similarity). Arachidonate 12-lipoxygenase activity is decreased when PH decreases from 7.4 to 6 (PubMed:11256953). Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. Cytoplasm, cytosol Membrane Note=Membrane association is stimulated by EGF. Found primarily in platelets and in microsomal and cytosolic fractions of the epidermis (at protein level). Mice are fertile and appear to exhibit no gross abnormalities. However, they display increased aggregation of platelets in response to ADP. They also display a mild basal transepidermal water loss. Belongs to the lipoxygenase family. arachidonate 12-lipoxygenase activity iron ion binding cytoplasm cytosol lipid metabolic process fatty acid metabolic process aging positive regulation of gene expression negative regulation of muscle cell apoptotic process positive regulation of cell death membrane linoleate 13S-lipoxygenase activity oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen hydrolase activity arachidonic acid metabolic process lipoxygenase pathway fatty acid oxidation unsaturated fatty acid metabolic process sarcolemma positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of blood vessel endothelial cell migration linoleic acid metabolic process metal ion binding hepoxilin-epoxide hydrolase activity positive regulation of smooth muscle cell proliferation arachidonate 15-lipoxygenase activity hepoxilin biosynthetic process dioxygenase activity positive regulation of mitochondrial depolarization oxidation-reduction process establishment of skin barrier cellular response to lipid negative regulation of platelet aggregation leukotriene A4 metabolic process lipoxin A4 biosynthetic process lipoxin B4 biosynthetic process uc007juj.1 uc007juj.2 uc007juj.3 
ENSMUST00000000342.3 Ccl11 ENSMUST00000000342.3 C-C motif chemokine ligand 11 (from RefSeq NM_011330.3) CCL11_MOUSE ENSMUST00000000342.1 ENSMUST00000000342.2 NM_011330 P48298 Scya11 uc007kmr.1 uc007kmr.2 uc007kmr.3 uc007kmr.4 In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils (PubMed:7568052, PubMed:8574847). Binds to CCR3 (By similarity). Secreted Expressed constitutively in the thymus. Expression inducible in the lung (type I alveolar epithelial cells), intestine, heart, spleen, kidney. By interferon gamma and lipopolysaccharides (LPS) (PubMed:7568052). By interleukin-13 (IL13) (PubMed:15647285). Belongs to the intercrine beta (chemokine CC) family. positive regulation of endothelial cell proliferation chronic inflammatory response monocyte chemotaxis mast cell chemotaxis cytokine activity extracellular region extracellular space chemotaxis inflammatory response immune response cytoskeleton organization actin filament organization G-protein coupled receptor signaling pathway learning or memory chemokine activity regulation of cell shape positive regulation of cell migration neutrophil chemotaxis positive regulation of actin filament polymerization killing of cells of other organism CCR3 chemokine receptor binding response to interleukin-13 positive regulation of GTPase activity positive regulation of angiogenesis protein dimerization activity receptor agonist activity CCR chemokine receptor binding eosinophil chemotaxis lymphocyte chemotaxis negative regulation of neurogenesis branching involved in mammary gland duct morphogenesis mammary duct terminal end bud growth chemokine-mediated signaling pathway ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade response to interleukin-4 cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor modulation of age-related behavioral decline uc007kmr.1 uc007kmr.2 uc007kmr.3 uc007kmr.4 
ENSMUST00000000348.15 Rtca ENSMUST00000000348.15 RNA 3'-terminal phosphate cyclase (from RefSeq NM_025517.3) ENSMUST00000000348.1 ENSMUST00000000348.10 ENSMUST00000000348.11 ENSMUST00000000348.12 ENSMUST00000000348.13 ENSMUST00000000348.14 ENSMUST00000000348.2 ENSMUST00000000348.3 ENSMUST00000000348.4 ENSMUST00000000348.5 ENSMUST00000000348.6 ENSMUST00000000348.7 ENSMUST00000000348.8 ENSMUST00000000348.9 NM_025517 Q3TVV2 Q9D7H3 RTCA_MOUSE Rpc1 RtcA Rtcd1 uc008rcd.1 uc008rcd.2 uc008rcd.3 uc008rcd.4 uc008rcd.5 Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA (By similarity). The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'- phosphorus in the diester linkage to produce the cyclic end product (By similarity). Likely functions in some aspects of cellular RNA processing (PubMed:25961792). Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury (PubMed:25961792). Reaction=a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'- cyclophospho-ribonucleotide-RNA + AMP + diphosphate; Xref=Rhea:RHEA:23976, Rhea:RHEA-COMP:10463, Rhea:RHEA-COMP:10464, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:83062, ChEBI:CHEBI:83064, ChEBI:CHEBI:456215; EC=6.5.1.4; Evidence=; Nucleus, nucleoplasm Detected in retinal ganglion cells (RGCs) (at protein level). Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily. nucleotide binding catalytic activity RNA-3'-phosphate cyclase activity ATP binding nucleus nucleoplasm RNA processing ligase activity uc008rcd.1 uc008rcd.2 uc008rcd.3 uc008rcd.4 uc008rcd.5 
ENSMUST00000000349.11 Dbt ENSMUST00000000349.11 dihydrolipoamide branched chain transacylase E2, transcript variant 1 (from RefSeq NM_010022.5) ENSMUST00000000349.1 ENSMUST00000000349.10 ENSMUST00000000349.2 ENSMUST00000000349.3 ENSMUST00000000349.4 ENSMUST00000000349.5 ENSMUST00000000349.6 ENSMUST00000000349.7 ENSMUST00000000349.8 ENSMUST00000000349.9 NM_010022 ODB2_MOUSE P53395 Q3TMF5 uc008rcg.1 uc008rcg.2 uc008rcg.3 uc008rcg.4 The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. Reaction=2-methylpropanoyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl- [protein] = CoA + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L- lysyl-[protein]; Xref=Rhea:RHEA:18865, Rhea:RHEA-COMP:10475, Rhea:RHEA-COMP:10497, ChEBI:CHEBI:57287, ChEBI:CHEBI:57338, ChEBI:CHEBI:83100, ChEBI:CHEBI:83142; EC=2.3.1.168; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18866; Evidence=; Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence=; Note=Binds 1 lipoyl cofactor covalently. ; Forms a 24-polypeptide structural core with octahedral symmetry that represents the E2 component of the branched-chain alpha- ketoacid dehydrogenase (BCKDH) complex. The BCKDH complex is composed of three major building blocks E1, E2 and E3. It is organized around E2, a 24-meric cubic core composed of DBT, to which are associated 6 to 12 copies of E1, and approximately 6 copies of the dehydrogenase E3, a DLD dimer (By similarity). Interacts with PPM1K with a 24:1 stoichiometry; the N-terminal region (residues 49-61) of PPM1K and C- terminal linker of the lipoyl domain of DBT/E2 (residues 145-160) are critical for this interaction whereas the lipoyl prosthetic group is dispensable. This interaction requires colocalization in mitochondria (By similarity). PPM1K competes with BCKDK for binding to DBT; this interaction is modulated by branched-chain alpha-keto acids (BCKAs). At steady state, BCKDH holoenzyme preferentially binds BCKDK and BCKDHA is phosphorylated. In response to high levels of BCKAs, BCKDK is replaced by PPM1K leading to BCKDHA dephosphorylation (By similarity). Mitochondrion matrix Belongs to the 2-oxoacid dehydrogenase family. cytoplasm mitochondrion mitochondrial matrix acetyltransferase activity transferase activity transferase activity, transferring acyl groups lipoic acid binding ubiquitin protein ligase binding mitochondrial nucleoid dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity uc008rcg.1 uc008rcg.2 uc008rcg.3 uc008rcg.4 
ENSMUST00000000356.10 Dazap2 ENSMUST00000000356.10 DAZ associated protein 2 (from RefSeq NM_011873.2) DAZP2_MOUSE ENSMUST00000000356.1 ENSMUST00000000356.2 ENSMUST00000000356.3 ENSMUST00000000356.4 ENSMUST00000000356.5 ENSMUST00000000356.6 ENSMUST00000000356.7 ENSMUST00000000356.8 ENSMUST00000000356.9 NM_011873 O88675 Prtb Q3UVI4 Q9DCP9 uc007xrt.1 uc007xrt.2 uc007xrt.3 In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1 (By similarity). In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters (By similarity). This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death (By similarity). Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes (PubMed:19304756). Plays a role in stress granule formation (By similarity). Interacts with SOX6 (PubMed:14530442). Interacts with DAZ1 and DAZL (By similarity). Interacts with IL17RB (By similarity). May interact with FAM168B (By similarity). Interacts with INCA1 (By similarity). Interacts with EIF4G1 and EIF4G2 (By similarity). Interacts (via PPAY motif) with NEDD4 (via WW domains) (By similarity). Interacts with transcription factor TCF4; the interaction results in localization of DAZAP2 to the nucleus (By similarity). Interacts with transcription factors TCF7 and TCF7L1 (By similarity). Interacts with transcription factor LEF1 (PubMed:19304756). Interacts with serine/threonine-protein kinase HIPK2; the interaction results in phosphorylation of DAZAP2 which causes localization of DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2- dependent degradation of HIPK2 (By similarity). Interacts with ubiquitin ligase SIAH1; the interaction is decreased following phosphorylation of DAZAP2 by HIPK2 (By similarity). Interacts with TP53; the interaction is triggered by DNA damage (By similarity). Cytoplasm Nucleus Nucleus speckle Nucleus, nuclear body Cytoplasm, Stress granule Note=Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm (By similarity). Predominantly cytoplasmic when unphosphorylated and localizes to the nucleus following phosphorylation by HIPK2 (By similarity). Localizes to stress granules under cellular stress conditions (By similarity). Widely expressed (PubMed:14530442, PubMed:19304756). Highly expressed in brain (PubMed:10373015). Between 11.5 dpc and 12.5 dpc it is specifically expressed in the developing heart. From 13.5 dpc, expression in the heart disappears, while it becomes strongly expressed in the brain. Up- regulated during adhesion and differentiation to beating cardiomyocytes. By serum stimulation. Ubiquitinated by SMURF2, leading to proteasomal degradation. Ubiquitinated by NEDD4, leading to proteasomal degradation. Following DNA damage, phosphorylated by HIPK2 which promotes DAZAP2 localization to the nucleus, reduces interaction of DAZAP2 with HIPK2 and SIAH1, and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent HIPK2 proteasomal degradation. protein binding nucleus transcription factor complex cytoplasm nuclear speck receptor tyrosine kinase binding mitogen-activated protein kinase kinase kinase binding macromolecular complex identical protein binding protein serine/threonine kinase activator activity WW domain binding positive regulation of protein serine/threonine kinase activity uc007xrt.1 uc007xrt.2 uc007xrt.3 
ENSMUST00000000365.3 Mcts1 ENSMUST00000000365.3 malignant T cell amplified sequence 1, transcript variant 1 (from RefSeq NM_026902.4) ENSMUST00000000365.1 ENSMUST00000000365.2 MCTS1_MOUSE NM_026902 Q3UUI6 Q9DB27 uc009tad.1 uc009tad.2 uc009tad.3 Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma- irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3 (By similarity). Interacts (via PUA domain) with DENR. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DB27-1; Sequence=Displayed; Name=2; IsoId=Q9DB27-2; Sequence=VSP_034857; The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly through interaction with other proteins (By similarity). Phosphorylation is critical for stabilization and promotion of cell proliferation. Belongs to the MCTS1 family. formation of translation preinitiation complex translation reinitiation RNA binding translation initiation factor activity cytoplasm cytosol plasma membrane translation translational initiation cellular response to DNA damage stimulus cell cycle cytosolic small ribosomal subunit ribosome disassembly regulation of growth IRES-dependent viral translational initiation uc009tad.1 uc009tad.2 uc009tad.3 
ENSMUST00000000369.4 Rem1 ENSMUST00000000369.4 rad and gem related GTP binding protein 1 (from RefSeq NM_009047.5) ENSMUST00000000369.1 ENSMUST00000000369.2 ENSMUST00000000369.3 NM_009047 O35929 REM1_MOUSE Rem uc008nfw.1 uc008nfw.2 uc008nfw.3 Promotes endothelial cell sprouting and actin cytoskeletal reorganization (By similarity). May be involved in angiogenesis. May function in Ca(2+) signaling. In vitro, interacts with calmodulin in a calcium-dependent manner (By similarity). Interacts 14-3-3 family members including YWHAE, YWHAH, YWHAQ, YWHAZ in a phosphorylation-dependent manner. High expression in cardiac muscle. Moderate expression in lung, skeletal muscle and kidney. Low levels in spleen and brain. Repressed by lipopolysaccharide stimulation. Belongs to the small GTPase superfamily. RGK family. nucleotide binding GTPase activity calcium channel regulator activity calmodulin binding GTP binding plasma membrane signal transduction biological_process membrane negative regulation of high voltage-gated calcium channel activity uc008nfw.1 uc008nfw.2 uc008nfw.3 
ENSMUST00000000384.8 Trappc10 ENSMUST00000000384.8 trafficking protein particle complex 10 (from RefSeq NM_001081055.2) ENSMUST00000000384.1 ENSMUST00000000384.2 ENSMUST00000000384.3 ENSMUST00000000384.4 ENSMUST00000000384.5 ENSMUST00000000384.6 ENSMUST00000000384.7 F8VQF9 NM_001081055 Q3TLI0 Q811H4 TPC10_MOUSE Tmem1 uc007fxm.1 uc007fxm.2 uc007fxm.3 uc007fxm.4 Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether. Specific component of the multisubunit TRAPP II complex, which includes at least TRAPPC1, TRAPPC2, TRAPPC3, TRAPPC4, TRAPPC5, TRAPPC6A/B, TRAPPC9, TRAPPC10 and TRAPPC14. TRAPPC9, TRAPPC10 and TRAPPC14 are specific subunits of the TRAPP II complex (PubMed:19656848). Interacts with TRAPPC14 (By similarity). Golgi apparatus, cis-Golgi network Gene-null mice have smaller total brain area compared to wild-type animals, with specific reductions in the size of the corpus callosum, regions of the hippocampus, anterior commissure, and internal capsule. Only white matter structures are affected in mutant mice. There is a loss of myelination in these regions, but oligodendrocyte numbers are normal. Belongs to the TRAPPC10 family. molecular_function Golgi apparatus cytosol intra-Golgi vesicle-mediated transport vesicle-mediated transport TRAPP complex early endosome to Golgi transport protein oligomerization TRAPPII protein complex uc007fxm.1 uc007fxm.2 uc007fxm.3 uc007fxm.4 
ENSMUST00000000388.15 Ccm2 ENSMUST00000000388.15 cerebral cavernous malformation 2, transcript variant 1 (from RefSeq NM_146014.3) CCM2_MOUSE ENSMUST00000000388.1 ENSMUST00000000388.10 ENSMUST00000000388.11 ENSMUST00000000388.12 ENSMUST00000000388.13 ENSMUST00000000388.14 ENSMUST00000000388.2 ENSMUST00000000388.3 ENSMUST00000000388.4 ENSMUST00000000388.5 ENSMUST00000000388.6 ENSMUST00000000388.7 ENSMUST00000000388.8 ENSMUST00000000388.9 NM_146014 Osm Q5SUA3 Q8K2Y9 uc007hyv.1 uc007hyv.2 uc007hyv.3 uc007hyv.4 Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock. Part of a complex with MAP2K3, MAP3K3 and RAC1. Binds RAC1 directly and independently of its nucleotide-bound state. Interacts with PDCD10 (By similarity). Interacts with HEG1 and KRIT1; KRIT1 greatly facilitates the interaction with HEG1. Cytoplasm Note=Treatment with sorbitol caused relocalization to ruffle-like structures. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2Y9-1; Sequence=Displayed; Name=2; IsoId=Q8K2Y9-2; Sequence=VSP_024404, VSP_024405; Highly expressed in heart, lower expression in kidney, lung and liver (at protein level). Expressed primarily in the developing neural tube at 10.5 dpc. The C-terminal region constitutes an independently folded domain that has structural similarity with the USH1C (harmonin) N- terminus, despite very low sequence similarity. Belongs to the CCM2 family. blood vessel development vasculogenesis in utero embryonic development endothelial cell development vasculature development protein binding cytoplasm mitochondrion heart development macromolecular complex multicellular organism growth cell-cell junction organization inner ear development venous blood vessel morphogenesis pericardium development blood vessel endothelial cell differentiation endothelial tube morphogenesis uc007hyv.1 uc007hyv.2 uc007hyv.3 uc007hyv.4 
ENSMUST00000000395.8 Tmprss2 ENSMUST00000000395.8 transmembrane protease, serine 2 (from RefSeq NM_015775.2) ENSMUST00000000395.1 ENSMUST00000000395.2 ENSMUST00000000395.3 ENSMUST00000000395.4 ENSMUST00000000395.5 ENSMUST00000000395.6 ENSMUST00000000395.7 NM_015775 Q7TN04 Q9JIQ8 Q9JKC4 Q9QY82 TMPS2_MOUSE uc008adl.1 uc008adl.2 Plasma membrane-anchored serine protease that cleaves at arginine residues (By similarity). Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro- hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption (By similarity). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (PubMed:25734995). (Microbial infection) Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9) and is involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. Reaction=The enzyme cleaves angiotensin-converting enzyme 2 (EC 3.4.17.23) and cleaves influenzea A and B virus and coronavirus spike glycoproteins at arginine residues.; EC=3.4.21.122; Evidence=; The catalytically active form interacts with ACE2. Cell membrane ; Single-pass type II membrane protein [Transmembrane protease serine 2 catalytic chain]: Secreted Note=Activated by cleavage and secreted. Larynx, trachea and bronchi, lung, prostate and kidney. Proteolytically processed; by an autocatalytic mechanism. Knockout mice show normal growth and reach normal adulthood without having abnormalities in organ histology and alteration in protein levels of prostatic secretions (PubMed:16428450). Abrogation of viral spread and protection of mice from severe pathology and death are observed after infection with influenza A virus strains H1N1 and H7N9. Belongs to the peptidase S1 family. serine-type endopeptidase activity scavenger receptor activity extracellular region plasma membrane proteolysis endocytosis peptidase activity serine-type peptidase activity membrane integral component of membrane protein autoprocessing hydrolase activity positive regulation of viral entry into host cell uc008adl.1 uc008adl.2 
ENSMUST00000000412.3 Egfl6 ENSMUST00000000412.3 EGF-like-domain, multiple 6 (from RefSeq NM_019397.3) EGFL6_MOUSE ENSMUST00000000412.1 ENSMUST00000000412.2 Maeg NM_019397 Q8BPM8 Q9JJZ5 uc009uww.1 uc009uww.2 uc009uww.3 May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly. Secreted, extracellular space, extracellular matrix, basement membrane Expressed at basement membrane of pelage follicles (at protein level). Detected in early lateral dermatome and in all dermatome derivatives. Expressed at the basement membrane of embryonic skin and developing hair follicles. At 16.5 dpc, present in lung epithelium, and developing oral and tooth germ epithelia (at protein level). Belongs to the nephronectin family. integrin binding calcium ion binding extracellular region basement membrane cell adhesion multicellular organism development positive regulation of cell-substrate adhesion membrane cell differentiation extracellular matrix organization extracellular matrix uc009uww.1 uc009uww.2 uc009uww.3 
ENSMUST00000000421.6 Tssk3 ENSMUST00000000421.6 testis-specific serine kinase 3 (from RefSeq NM_080442.2) ENSMUST00000000421.1 ENSMUST00000000421.2 ENSMUST00000000421.3 ENSMUST00000000421.4 ENSMUST00000000421.5 NM_080442 Q9D2E1 Q9JL98 Stk22c Stk22d TSSK3_MOUSE uc008uxc.1 uc008uxc.2 uc008uxc.3 May be involved in a signaling pathway during male germ cell development or mature sperm function. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation on Thr-168, potentially by autophosphorylation. Developmentally expressed in testicular germ cells. In adult testis, expression was detected in round and condensing spermatids, but not in meiotic pachytene spermatocytes. Not expressed in brain, ovary, kidney, liver or early embryonic cells. Expression begins 20-24 days after birth and is maximal in the adult. The pattern of expression suggests that STK22D is expressed postmeiotically. Autophosphorylated. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PubMed:10781952 has termed the gene 'STK22D' as it was then thought that there were two different closely related genes. Sequence=AAF72581.1; Type=Frameshift; Evidence=; nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation multicellular organism development spermatogenesis kinase activity phosphorylation transferase activity cell differentiation intracellular signal transduction metal ion binding sperm capacitation uc008uxc.1 uc008uxc.2 uc008uxc.3 
ENSMUST00000000430.14 Galnt1 ENSMUST00000000430.14 polypeptide N-acetylgalactosaminyltransferase 1, transcript variant 1 (from RefSeq NM_013814.3) ENSMUST00000000430.1 ENSMUST00000000430.10 ENSMUST00000000430.11 ENSMUST00000000430.12 ENSMUST00000000430.13 ENSMUST00000000430.2 ENSMUST00000000430.3 ENSMUST00000000430.4 ENSMUST00000000430.5 ENSMUST00000000430.6 ENSMUST00000000430.7 ENSMUST00000000430.8 ENSMUST00000000430.9 GALT1_MOUSE Galnt1 NM_013814 O08912 Q5BKS3 Q7TND1 uc008egq.1 uc008egq.2 uc008egq.3 uc008egq.4 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:9153242, PubMed:10037781). Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides (By similarity). Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23957; Evidence=; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52425; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. [Polypeptide N-acetylgalactosaminyltransferase 1]: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein [Polypeptide N-acetylgalactosaminyltransferase 1 soluble form]: Secreted Widely expressed at high level. Higher expression in kidney, heart, small intestine and cervix and to a lesser extent in all the other tissues tested. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates (By similarity). Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Name=Functional Glycomics Gateway - GTase; Note=Polypeptide N-acetylgalactosaminyltransferase 1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_510"; polypeptide N-acetylgalactosaminyltransferase activity extracellular region Golgi apparatus protein glycosylation protein O-linked glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via serine protein O-linked glycosylation via threonine manganese ion binding carbohydrate binding Golgi cisterna membrane metal ion binding perinuclear region of cytoplasm uc008egq.1 uc008egq.2 uc008egq.3 uc008egq.4 
ENSMUST00000000445.2 Myf5 ENSMUST00000000445.2 myogenic factor 5 (from RefSeq NM_008656.5) ENSMUST00000000445.1 MYF5_MOUSE Myf-5 NM_008656 P24699 Q543W7 uc007gyz.1 uc007gyz.2 Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. Efficient DNA binding requires dimerization with another bHLH protein. Nucleus. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cartilage condensation ossification somitogenesis regulation of cell-matrix adhesion DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development muscle organ development skeletal muscle tissue development cell differentiation extracellular matrix organization skeletal muscle cell differentiation camera-type eye development sequence-specific DNA binding positive regulation of myoblast differentiation positive regulation of transcription from RNA polymerase II promoter protein dimerization activity muscle organ morphogenesis embryonic skeletal system morphogenesis positive regulation of skeletal muscle fiber development muscle tissue morphogenesis positive regulation of myoblast fusion uc007gyz.1 uc007gyz.2 
ENSMUST00000000449.9 Mkrn2 ENSMUST00000000449.9 makorin, ring finger protein, 2 (from RefSeq NM_023290.3) ENSMUST00000000449.1 ENSMUST00000000449.2 ENSMUST00000000449.3 ENSMUST00000000449.4 ENSMUST00000000449.5 ENSMUST00000000449.6 ENSMUST00000000449.7 ENSMUST00000000449.8 MKRN2_MOUSE NM_023290 Q6GTY9 Q9D0L9 Q9ERV1 uc057bxw.1 uc057bxw.2 uc057bxw.3 E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:28378844). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappa-B transactivation and negatively regulating inflammatory responses (PubMed:28378844). Plays a role in the regulation of spermiation and in male fertility (PubMed:28008940). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with PDLIM2 (via LIM zinc-binding domain) (PubMed:28378844). Interacts with RELA (PubMed:28378844). Cytoplasm Nucleus Highly expressed in the testis, and lower expression in the brain, thymus, heart, lung, liver, spleen, kidney, ovary, uterus, and seminal vesicle (at protein level) (PubMed:28008940). Expressed in primary immune cells, such as CD4- positive and CD8-positive T cells, CD19-positive B cells and CD11c- positive dendritic cells, and in embryonic fibroblasts (at protein level) (PubMed:28378844). Male and female knockout mice are viable with a lighter birthweight than wild-type animals (PubMed:28008940). Causes infertility in male mice, whereas female mice are fertile, but display reduced fecundity (PubMed:28008940). Leads to abnormal sperms characterized by low number, poor motility, and aberrant morphology (PubMed:28008940). Sperms have deformed heads with abnormal or missing acrosomes, disorganized axonemal structure, and disorganized flagellar structure (PubMed:28008940). Complete loss of the axoneme doublets in one side of the fibrous sheath and disordered assembly of axoneme doublets (PubMed:28008940). Causes failure of sperm release (spermiation failure) and misarrangement of ectoplasmic specialization in testes, thus impairing spermiogenesis and spermiation (PubMed:28008940). Disrupted arrangement of ectoplasmic specialization, the adhesion junction found in Sertoli cells at sites of attachment to elongated spermatids or neighboring Sertoli cells in the testes, and decreased expression of Espn (PubMed:28008940). The outer dense fiber, which is an important component of flagellae, is absent or improperly arranged in epididymal sperms (PubMed:28008940). Decreased expression levels of Odf2 in spermatogenesis (PubMed:28008940). molecular_function biological_process protein ubiquitination transferase activity metal ion binding uc057bxw.1 uc057bxw.2 uc057bxw.3 
ENSMUST00000000451.14 Raf1 ENSMUST00000000451.14 v-raf-leukemia viral oncogene 1, transcript variant 1 (from RefSeq NM_029780.4) Craf ENSMUST00000000451.1 ENSMUST00000000451.10 ENSMUST00000000451.11 ENSMUST00000000451.12 ENSMUST00000000451.13 ENSMUST00000000451.2 ENSMUST00000000451.3 ENSMUST00000000451.4 ENSMUST00000000451.5 ENSMUST00000000451.6 ENSMUST00000000451.7 ENSMUST00000000451.8 ENSMUST00000000451.9 NM_029780 Q3UR68 Q58E75 Q91WH1 Q99N57 Q99N58 Q9QUU8 RAF1_MOUSE uc009diy.1 uc009diy.2 uc009diy.3 Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity). Regulates Rho signaling and migration, and is required for normal wound healing. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Regulation is a highly complex process involving membrane recruitment, protein-protein interactions, dimerization, and phosphorylation/dephosphorylation events. Ras-GTP recruits RAF1 to the membrane, thereby promoting its activation. The inactive conformation of RAF1 is maintained by autoinhibitory interactions occurring between the N-terminal regulatory and the C-terminal catalytic domains and by the binding of a 14-3-3 protein that contacts two phosphorylation sites, Ser-259 and Ser-621. Upon mitogenic stimulation, Ras and PPP2R1A cooperate to release autoinhibition and the subsequent phosphorylation of activating sites: Ser-338, Tyr-341, Thr-491, and Ser-494, yields a fully active kinase. Through a negative feedback mechanism involving MAPK1/ERK2, RAF1 is phosphorylated on Ser-29, Ser-43, Ser-289, Ser-296, Ser-301 and Ser-642 by MAPK1/ERK2, which yields an inactive, desensitized kinase. The signaling-competent conformation of RAF1 is finally re-established by the coordinated action of PIN1, a prolyl isomerase that converts pSer and pThr residues from the cis to the trans conformation, which is preferentially recognized and dephosphorylated by PPP2R1A. Activated by homodimerization and heterodimerization (with BRAF). Also regulated through association with other proteins such as KSR2, CNKSR1/CNK1, PEBP1/RKIP, PHB/prohibitin and SPRY4. PEBP1/RKIP acts by dissociating RAF1 from its substrates MAP2K1/MEK1 and MAP2K2/MEK2. PHB/prohibitin facilitates the displacement of 14-3-3 from RAF1 by activated Ras, thereby promoting cell membrane localization and phosphorylation of RAF1 at the activating Ser-338. SPRY4 inhibits Ras-independent, but not Ras- dependent, activation of RAF1. CNKSR1/CNK1 regulates Src-mediated RAF1 activation (By similarity). Monomer (By similarity). Homodimer (By similarity). Heterodimerizes with BRAF and this heterodimer possesses a highly increased kinase activity compared to the respective homodimers or monomers (By similarity). Heterodimerization is mitogen-regulated and enhanced by 14-3-3 proteins (By similarity). MAPK1/ERK2 activation can induce a negative feedback that promotes the dissociation of the heterodimer (By similarity). Forms a multiprotein complex with Ras (M- Ras/MRAS), SHOC2 and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC) (By similarity). Interacts with LZTR1 (By similarity). Interacts with Ras proteins; the interaction is antagonized by RIN1 (By similarity). Weakly interacts with RIT1 (By similarity). Interacts (via N-terminus) with RGS14 (via RBD domains); the interaction mediates the formation of a ternary complex with BRAF, a ternary complex inhibited by GNAI1 (By similarity). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (By similarity). Interacts with STK3/MST2; the interaction inhibits its pro-apoptotic activity (By similarity). Interacts (when phosphorylated at Ser-259) with YWHAZ (unphosphorylated at 'Thr-232') (By similarity). Interacts with MAP2K1/MEK1 and MAP2K2/MEK2 (By similarity). Interacts with MAP3K5/ASF1 (via N- terminus) and this interaction inhibits the proapoptotic function of MAP3K5/ASK1 (By similarity). Interacts with PAK1 (via kinase domain) (By similarity). The Ser-338 and Ser-339 phosphorylated form (by PAK1) interacts with BCL2 (By similarity). Interacts with PEBP1/RKIP and this interaction is enhanced if RAF1 is phosphorylated on residues Ser-338, Ser-339, Tyr-340 and Tyr-341 (By similarity). Interacts with ADCY2, ADCY5, ADCY6, DGKH, RCAN1/DSCR1, PPP1R12A, PKB/AKT1, SPRY2, SPRY4, CNKSR1/CNK1, KSR2 and PHB/prohibitin (By similarity). The phosphorylated form interacts with PIN1 (PubMed:15664191). Interacts with PPP2CA, PPP2R1B and ROCK2 (PubMed:15753127, PubMed:15664191). In its active form, interacts with PRMT5 (By similarity). Interacts with FAM83B; displaces 14-3-3 proteins from RAF1 and activates RAF1 (By similarity). Interacts with PDE8A; the interaction promotes RAF1 activity (By similarity). Interacts with MFHAS1 (By similarity). Interacts with GLS (By similarity). Interacts with NEK10 and MAP2K1; the interaction is direct with NEK10 and required for ERK1/2-signaling pathway activation in response to UV irradiation (By similarity). Q99N57; P28028: Braf; NbExp=2; IntAct=EBI-397757, EBI-2584830; Q99N57; P32883-2: Kras; NbExp=3; IntAct=EBI-397757, EBI-644285; Q99N57; Q8CFI0: Nedd4l; NbExp=2; IntAct=EBI-397757, EBI-8046183; Q99N57; Q9WVC6: Sgk1; NbExp=2; IntAct=EBI-397757, EBI-15591730; Q99N57; Q9Z2S7-3: Tsc22d3; NbExp=2; IntAct=EBI-397757, EBI-15771036; Q99N57; P15056: BRAF; Xeno; NbExp=3; IntAct=EBI-397757, EBI-365980; Q99N57; P01111: NRAS; Xeno; NbExp=2; IntAct=EBI-397757, EBI-721993; Cytoplasm Cell membrane Mitochondrion Nucleus Note=Colocalizes with RGS14 and BRAF in both the cytoplasm and membranes. Phosphorylation at Ser-259 impairs its membrane accumulation. Recruited to the cell membrane by the active Ras protein. Phosphorylation at Ser-338 and Ser-339 by PAK1 is required for its mitochondrial localization (By similarity). Retinoic acid- induced Ser-621 phosphorylated form of RAF1 is predominantly localized at the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=6C; IsoId=Q99N57-1; Sequence=Displayed; Name=2; Synonyms=1A; IsoId=Q99N57-2; Sequence=VSP_034629; Present in all tissues tested: testis, ovary, small intestine, colon, peripheral blood leukocytes, fetal liver, bone marrow, thymus, lymph node and spleen, and the cell lines melanoma G- 361, lung carcinoma A-549, colorectal adenocarcinoma SW480, Burkitt's lymphoma Raji and lymphoblastic leukemia MOLT-4. In skeletal muscle, isoform 1 is more abundant than isoform 2. Phosphorylation at Thr-269, Ser-338, Tyr-341, Thr-491 and Ser-494 results in its activation. Phosphorylation at Ser-29, Ser-43, Ser-289, Ser-296, Ser-301 and Ser-642 by MAPK1/ERK2 results in its inactivation. Phosphorylation at Ser-259 induces the interaction with YWHAZ and inactivates kinase activity. Dephosphorylation of Ser-259 by the complex containing protein phosphatase 1, SHOC2 and M-Ras/MRAS relieves inactivation, leading to stimulate RAF1 activity. Phosphorylation at Ser-338 by PAK1 and PAK5 and Ser-339 by PAK1 is required for its mitochondrial localization (By similarity). Phosphorylation at Ser-621 in response to growth factor treatment stabilizes the protein, possibly by preventing proteasomal degradation. Phosphorylation at Ser-289, Ser- 296, Ser-301, Ser-338 and Ser-621 are somehow linked to the methylation potential of cells. Treatment of cells with HGF in the presence of the methylation inhibitor 5'-methylthioadenosine (MTA) results in increased phosphorylation at Ser-338 and Ser-621 and decreased phosphorylation at Ser-296, Ser-301 and Ser-338. Dephosphorylation at Ser-338 by PPP5C results in a decreased of activity (By similarity). Methylated at Arg-563 in response to EGF treatment. This modification leads to destabilization of the protein, possibly through proteasomal degradation. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. MAPK cascade nucleotide binding activation of MAPKK activity response to hypoxia cellular glucose homeostasis positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity protein binding ATP binding nucleus cytoplasm mitochondrion Golgi apparatus cytosol plasma membrane protein phosphorylation signal transduction activation of adenylate cyclase activity heart development adenylate cyclase binding negative regulation of cell proliferation adenylate cyclase activator activity membrane kinase activity phosphorylation nuclear speck transferase activity Ras GTPase binding enzyme binding cell differentiation thyroid gland development pseudopodium negative regulation of protein complex assembly mitogen-activated protein kinase kinase binding positive regulation of peptidyl-serine phosphorylation somatic stem cell population maintenance intracellular signal transduction insulin secretion involved in cellular response to glucose stimulus response to muscle stretch identical protein binding negative regulation of apoptotic process intermediate filament cytoskeleton organization positive regulation of transcription from RNA polymerase II promoter metal ion binding protein heterodimerization activity neurotrophin TRK receptor signaling pathway thymus development face development death-inducing signaling complex assembly negative regulation of extrinsic apoptotic signaling pathway via death domain receptors uc009diy.1 uc009diy.2 uc009diy.3 
ENSMUST00000000466.13 Plin2 ENSMUST00000000466.13 perilipin 2, transcript variant 1 (from RefSeq NM_007408.4) Adfp Adrp ENSMUST00000000466.1 ENSMUST00000000466.10 ENSMUST00000000466.11 ENSMUST00000000466.12 ENSMUST00000000466.2 ENSMUST00000000466.3 ENSMUST00000000466.4 ENSMUST00000000466.5 ENSMUST00000000466.6 ENSMUST00000000466.7 ENSMUST00000000466.8 ENSMUST00000000466.9 NM_007408 P43883 PLIN2_MOUSE Q8K3Q8 uc008tlz.1 uc008tlz.2 uc008tlz.3 Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. P43883; P63017: Hspa8; NbExp=3; IntAct=EBI-16156700, EBI-433443; Membrane ; Peripheral membrane protein Lipid droplet Adipose tissue specific. Expressed abundantly and preferentially in fat pads. By dexamethasone. Acylated; primarily with C14, C16 and C18 fatty acids. Phosphorylation at Tyr-230 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis. Belongs to the perilipin family. protein binding nucleus cytoplasm lipid particle cytosol plasma membrane response to organic cyclic compound long-chain fatty acid transport membrane lipid storage response to drug uc008tlz.1 uc008tlz.2 uc008tlz.3 
ENSMUST00000000476.15 Pdgfra ENSMUST00000000476.15 platelet derived growth factor receptor, alpha polypeptide, transcript variant 2 (from RefSeq NM_011058.3) ENSMUST00000000476.1 ENSMUST00000000476.10 ENSMUST00000000476.11 ENSMUST00000000476.12 ENSMUST00000000476.13 ENSMUST00000000476.14 ENSMUST00000000476.2 ENSMUST00000000476.3 ENSMUST00000000476.4 ENSMUST00000000476.5 ENSMUST00000000476.6 ENSMUST00000000476.7 ENSMUST00000000476.8 ENSMUST00000000476.9 NM_011058 P26618 PGFRA_MOUSE Q3TQ37 Q62046 Q7TSJ3 Q8C4N3 uc008xuc.1 uc008xuc.2 uc008xuc.3 This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice. [provided by RefSeq, Jan 2017]. Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib, nilotinib and sorafenib (By similarity). Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand. Interaction with dimeric PDGFA, PDGFB and/or PDGFC leads to receptor dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts (tyrosine phosphorylated) with SHB (via SH2 domain). Interacts (tyrosine phosphorylated) with SHF (via SH2 domain). Interacts (tyrosine phosphorylated) with SRC (via SH2 domain). Interacts (tyrosine phosphorylated) with PIK3R1. Interacts (tyrosine phosphorylated) with PLCG1 (via SH2 domain). Interacts (tyrosine phosphorylated) with CRK, GRB2 and GRB7 (By similarity). Cell membrane ; Single-pass type I membrane protein Cell projection, cilium Golgi apparatus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P26618-1; Sequence=Displayed; Name=2; IsoId=P26618-2; Sequence=VSP_031877, VSP_031878; Focally expressed in cortical interstitial cells and highly expressed in the interstitium of the papillary region. Also expressed by adventitial cells in arterial vessels. Up-regulated in areas of renal fibrosis. In mice with unilateral ureteral obstruction, expression in cortical interstitial cells becomes prominent at day 4 which increases progressively until day 14. Up-regulated by growth arrest. Ubiquitinated, leading to its internalization and degradation. Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-731 and Tyr-742 is important for interaction with PIK3R1. Phosphorylation at Tyr-720 and Tyr-754 is important for interaction with PTPN11. Phosphorylation at Tyr-762 is important for interaction with CRK. Phosphorylation at Tyr-572 and Tyr-574 is important for interaction with SRC and SRC family members. Phosphorylation at Tyr-988 and Tyr-1018 is important for interaction with PLCG1 (By similarity). Embryonically lethal. Most embryos survive up to 13 dpc, but display important defects in skeleton development, including spina bifida, fusions of cervical vertebrae and ribs, and incomplete fusion of the skull parietal bone. Embryos display also abnormal mucosa lining the gastrointestinal tract, including fewer and misshapen villi and loss of pericryptal mesenchyme. At about 16 dpc, embryos display extensive hemorrhaging. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. nucleotide binding luteinization in utero embryonic development hematopoietic progenitor cell differentiation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity platelet-derived growth factor alpha-receptor activity vascular endothelial growth factor-activated receptor activity platelet-derived growth factor receptor binding ATP binding nucleus cytoplasm Golgi apparatus plasma membrane integral component of plasma membrane microvillus cilium protein phosphorylation chemotaxis transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cytosolic calcium ion concentration multicellular organism development estrogen metabolic process positive regulation of cell proliferation female gonad development anatomical structure morphogenesis animal organ morphogenesis external side of plasma membrane cell surface negative regulation of platelet activation positive regulation of phospholipase C activity membrane integral component of membrane kinase activity phosphorylation cell migration transferase activity peptidyl-tyrosine phosphorylation signal transduction involved in regulation of gene expression cell junction extracellular matrix organization lung development adrenal gland development positive regulation of cell migration axon male genitalia development intrinsic component of plasma membrane macromolecular complex Leydig cell differentiation cellular response to reactive oxygen species platelet-derived growth factor receptor-alpha signaling pathway vascular endothelial growth factor binding positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway wound healing odontogenesis of dentin-containing tooth protein homodimerization activity cell projection receptor complex phosphatidylinositol 3-kinase binding positive regulation of phosphatidylinositol 3-kinase activity macromolecular complex binding protein autophosphorylation platelet-derived growth factor receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of fibroblast proliferation platelet-derived growth factor binding embryonic digestive tract morphogenesis embryonic cranial skeleton morphogenesis skeletal system morphogenesis positive regulation of peptidyl-tyrosine phosphorylation regulation of chemotaxis cardiac myofibril assembly palate development face morphogenesis cell chemotaxis lung growth positive regulation of branching involved in lung morphogenesis retina vasculature development in camera-type eye positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to amino acid stimulus metanephric glomerular capillary formation regulation of mesenchymal stem cell differentiation uc008xuc.1 uc008xuc.2 uc008xuc.3 
ENSMUST00000000500.8 Pdgfb ENSMUST00000000500.8 platelet derived growth factor, B polypeptide, transcript variant 6 (from RefSeq NR_177437.1) A0A0R4IZW4 A0A0R4IZW4_MOUSE ENSMUST00000000500.1 ENSMUST00000000500.2 ENSMUST00000000500.3 ENSMUST00000000500.4 ENSMUST00000000500.5 ENSMUST00000000500.6 ENSMUST00000000500.7 NR_177437 Pdgfb uc007wuz.1 uc007wuz.2 uc007wuz.3 Secreted Belongs to the PDGF/VEGF growth factor family. positive regulation of endothelial cell proliferation monocyte chemotaxis platelet-derived growth factor receptor binding collagen binding protein phosphorylation growth factor activity positive regulation of cell proliferation response to wounding cell surface negative regulation of phosphatidylinositol biosynthetic process negative regulation of platelet activation positive regulation of gene expression negative regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of smooth muscle cell migration membrane superoxide-generating NADPH oxidase activator activity peptidyl-serine phosphorylation peptidyl-tyrosine phosphorylation positive regulation of cell migration positive regulation of protein autophosphorylation negative regulation of protein binding activation of protein kinase activity activation of protein kinase B activity interleukin-18-mediated signaling pathway positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway chemoattractant activity identical protein binding protein homodimerization activity positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration positive regulation of phosphatidylinositol 3-kinase activity positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated protein heterodimerization activity platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation platelet-derived growth factor binding positive regulation of smooth muscle cell proliferation positive regulation of peptidyl-tyrosine phosphorylation positive chemotaxis positive regulation of chemotaxis cell chemotaxis positive regulation of protein tyrosine kinase activity positive regulation of ERK1 and ERK2 cascade protein kinase C signaling cellular response to growth factor stimulus positive regulation of glomerular mesangial cell proliferation reactive oxygen species metabolic process positive regulation of calcium ion import positive regulation of hyaluronan biosynthetic process negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration negative regulation of vascular smooth muscle cell differentiation positive regulation of vascular smooth muscle cell dedifferentiation positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process positive regulation of metanephric mesenchymal cell migration uc007wuz.1 uc007wuz.2 uc007wuz.3 
ENSMUST00000000505.16 Mcm7 ENSMUST00000000505.16 minichromosome maintenance complex component 7, transcript variant 1 (from RefSeq NM_008568.3) Cdc47 ENSMUST00000000505.1 ENSMUST00000000505.10 ENSMUST00000000505.11 ENSMUST00000000505.12 ENSMUST00000000505.13 ENSMUST00000000505.14 ENSMUST00000000505.15 ENSMUST00000000505.2 ENSMUST00000000505.3 ENSMUST00000000505.4 ENSMUST00000000505.5 ENSMUST00000000505.6 ENSMUST00000000505.7 ENSMUST00000000505.8 ENSMUST00000000505.9 MCM7_MOUSE Mcmd7 NM_008568 Q61881 uc009aeu.1 uc009aeu.2 uc009aeu.3 Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Uncomplexed form does not show ATPase or DNA helicase (PubMed:12207017). Required for S-phase checkpoint activation upon UV- induced damage (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7- MCM3-MCM5. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex. Interacts with the ATR-ATRIP complex and with RAD17. Interacts with TIPIN. Interacts with MCMBP. Interacts with ANKRD17. Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR. Q61881; P46414: Cdkn1b; NbExp=2; IntAct=EBI-457180, EBI-1005742; Nucleus Chromosome Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. Ubiquitinated by ECS(LRR1) E3 ubiquitin-protein ligase complex when forks converge following formation of DNA interstrand cross-links (PubMed:33590678). During mitosis, ubiquitinated by TRAIP when forks converge following formation of DNA interstrand cross-links (PubMed:33590678). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase (PubMed:33590678). Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex. Belongs to the MCM family. nucleotide binding double-strand break repair via break-induced replication DNA binding DNA helicase activity DNA replication origin binding single-stranded DNA binding helicase activity protein binding ATP binding nucleus nucleoplasm cytosol DNA replication pre-replicative complex assembly involved in nuclear cell cycle DNA replication DNA unwinding involved in DNA replication DNA replication initiation DNA strand elongation involved in DNA replication cellular response to DNA damage stimulus cell cycle cell proliferation hydrolase activity regulation of phosphorylation response to drug MCM complex cellular response to organic substance cellular response to epidermal growth factor stimulus cellular response to xenobiotic stimulus single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity uc009aeu.1 uc009aeu.2 uc009aeu.3 
ENSMUST00000000542.14 Acvrl1 ENSMUST00000000542.14 activin A receptor, type II-like 1, transcript variant 1 (from RefSeq NM_009612.3) ACVL1_MOUSE Acvrlk1 Alk-1 ENSMUST00000000542.1 ENSMUST00000000542.10 ENSMUST00000000542.11 ENSMUST00000000542.12 ENSMUST00000000542.13 ENSMUST00000000542.2 ENSMUST00000000542.3 ENSMUST00000000542.4 ENSMUST00000000542.5 ENSMUST00000000542.6 ENSMUST00000000542.7 ENSMUST00000000542.8 ENSMUST00000000542.9 NM_009612 Q61288 Q61289 Q91YR0 uc007xsm.1 uc007xsm.2 uc007xsm.3 Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA- COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Interacts with TSC22D1/TSC-22. Cell membrane ; Single-pass type I membrane protein Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. nucleotide binding angiogenesis response to hypoxia in utero embryonic development negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation lymphangiogenesis blood vessel remodeling endocardial cushion morphogenesis protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I protein binding ATP binding plasma membrane integral component of plasma membrane regulation of transcription, DNA-templated protein phosphorylation negative regulation of cell adhesion signal transduction transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway pattern specification process blood circulation regulation of blood pressure negative regulation of cell proliferation cell surface negative regulation of endothelial cell migration negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation membrane integral component of membrane kinase activity phosphorylation activin receptor activity, type I transferase activity growth factor binding protein kinase binding negative regulation of cell growth negative regulation of cell migration dendrite BMP signaling pathway positive regulation of BMP signaling pathway activin receptor signaling pathway wound healing, spreading of epidermal cells dorsal aorta morphogenesis endothelial cell activation neuronal cell body receptor complex negative regulation of blood vessel endothelial cell migration negative regulation of endothelial cell differentiation positive regulation of endothelial cell differentiation positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter SMAD binding metal ion binding activin receptor complex activin binding blood vessel morphogenesis transforming growth factor beta binding negative regulation of focal adhesion assembly lymphatic endothelial cell differentiation artery development venous blood vessel development endothelial tube morphogenesis retina vasculature development in camera-type eye cellular response to transforming growth factor beta stimulus cellular response to BMP stimulus BMP receptor activity negative regulation of DNA biosynthetic process endocardial cushion to mesenchymal transition uc007xsm.1 uc007xsm.2 uc007xsm.3 
ENSMUST00000000543.6 Tamalin ENSMUST00000000543.6 trafficking regulator and scaffold protein tamalin (from RefSeq NM_019518.3) ENSMUST00000000543.1 ENSMUST00000000543.2 ENSMUST00000000543.3 ENSMUST00000000543.4 ENSMUST00000000543.5 GRASP_MOUSE Grasp MNCb-4428 NM_019518 Q9JJA9 Q9JKL0 Tamalin uc007xsu.1 uc007xsu.2 uc007xsu.3 Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. Heteromer. Composed of TAMALIN, CYTH2 and at least one GRM1. Also interacts with GRM2, GRM3 and GRM5 (By similarity). Interacts with CYTH3 (PubMed:10828067). Cytoplasm, perinuclear region Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Postsynaptic cell membrane Highly expressed in brain, heart and lung, and to a lower extent in embryo, kidney and ovary. protein binding nuclear envelope lumen cytoplasm plasma membrane intracellular protein transport signal transduction protein localization postsynaptic density membrane PDZ domain binding ADP-ribosylation factor binding identical protein binding glutamatergic synapse uc007xsu.1 uc007xsu.2 uc007xsu.3 
ENSMUST00000000544.12 Acvr1b ENSMUST00000000544.12 activin A receptor, type 1B (from RefSeq NM_007395.4) ACV1B_MOUSE Alk4 ENSMUST00000000544.1 ENSMUST00000000544.10 ENSMUST00000000544.11 ENSMUST00000000544.2 ENSMUST00000000544.3 ENSMUST00000000544.4 ENSMUST00000000544.5 ENSMUST00000000544.6 ENSMUST00000000544.7 ENSMUST00000000544.8 ENSMUST00000000544.9 NM_007395 Q61271 uc007xsr.1 uc007xsr.2 uc007xsr.3 Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine- threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type- 1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA- COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Activin receptor type-2 (ACVR2A or ACVR2B) activates the type-1 receptor through phosphorylation of its regulatory GS domain. Forms an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B) (By similarity). Part of a complex consisting of MAGI2/ARIP1, ACVR2A, ACVR1B and SMAD3 (PubMed:10681527). Interacts with SMAD2 and SMAD3 (By similarity). Interacts with SMAD7 (By similarity). Interacts with FKBP1A (By similarity). Interacts with IGSF1 (By similarity). Interacts with CRIPTO (By similarity). Interacts with TDP2 (PubMed:18039968). Interacts with TSC22D1/TSC-22 (By similarity). Cell membrane ; Single-pass type I membrane protein The GS domain is a 30-amino-acid sequence adjacent to the N- terminal boundary of the kinase domain and highly conserved in all other known type-1 receptors but not in type-2 receptors. The GS domain is the site of activation through phosphorylation by the II receptors (By similarity). Autophosphorylated. Phosphorylated by activin receptor type-2 (ACVR2A or ACVR2B) in response to activin-binding at serine and threonine residues in the GS domain. Phosphorylation of ACVR1B by activin receptor type-2 regulates association with SMAD7 (By similarity). Ubiquitinated. Level of ubiquitination is regulated by the SMAD7- SMURF1 complex (By similarity). Ubiquitinated. Leads to hair loss. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. G1/S transition of mitotic cell cycle nucleotide binding in utero embryonic development hair follicle development protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I protein binding ATP binding cytosol plasma membrane integral component of plasma membrane regulation of transcription, DNA-templated protein phosphorylation signal transduction cell surface receptor signaling pathway transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway pattern specification process central nervous system development mesoderm development regulation of signal transduction cell surface positive regulation of gene expression negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation membrane integral component of membrane kinase activity phosphorylation activin receptor activity, type I transferase activity activin-activated receptor activity peptidyl-threonine phosphorylation growth factor binding negative regulation of cell growth activin receptor signaling pathway positive regulation of activin receptor signaling pathway inhibin binding nodal signaling pathway receptor complex positive regulation of erythrocyte differentiation positive regulation of transcription from RNA polymerase II promoter SMAD binding development of primary female sexual characteristics protein autophosphorylation metal ion binding activin receptor complex activin binding extrinsic apoptotic signaling pathway positive regulation of trophoblast cell migration uc007xsr.1 uc007xsr.2 uc007xsr.3 
ENSMUST00000000573.9 Ovgp1 ENSMUST00000000573.9 oviductal glycoprotein 1 (from RefSeq NM_007696.2) Chit5 ENSMUST00000000573.1 ENSMUST00000000573.2 ENSMUST00000000573.3 ENSMUST00000000573.4 ENSMUST00000000573.5 ENSMUST00000000573.6 ENSMUST00000000573.7 ENSMUST00000000573.8 NM_007696 OVGP1_MOUSE Ogp Q62010 uc008qvq.1 uc008qvq.2 uc008qvq.3 Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules. Epithelial cells of the oviduct. Belongs to the glycosyl hydrolase 18 family. chitinase activity extracellular region cytoplasm carbohydrate metabolic process chitin catabolic process single fertilization chitin binding transport vesicle cytoplasmic vesicle egg coat perivitelline space negative regulation of binding of sperm to zona pellucida uc008qvq.1 uc008qvq.2 uc008qvq.3 
ENSMUST00000000574.3 Adora3 ENSMUST00000000574.3 adenosine A3 receptor (from RefSeq NM_009631.4) Adora3 ENSMUST00000000574.1 ENSMUST00000000574.2 NM_009631 Q3U4C5 Q3U4C5_MOUSE uc008qvi.1 uc008qvi.2 uc008qvi.3 uc008qvi.4 This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. This gene shares its 3' terminal exon with a transcript variant from overlapping GeneID:69296, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK013534.1, AK154312.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled adenosine receptor activity adenosine receptor signaling pathway G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway negative regulation of cell proliferation membrane integral component of membrane negative regulation of cell migration negative regulation of NF-kappaB transcription factor activity uc008qvi.1 uc008qvi.2 uc008qvi.3 uc008qvi.4 
ENSMUST00000000579.3 Sox9 ENSMUST00000000579.3 SRY (sex determining region Y)-box 9 (from RefSeq NM_011448.4) ENSMUST00000000579.1 ENSMUST00000000579.2 NM_011448 Q04887 Q8C7L2 Q91ZK2 Q99KQ0 SOX9_MOUSE Sox-9 Sox9 uc007med.1 uc007med.2 uc007med.3 uc007med.4 Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:10319868, PubMed:11371614, PubMed:12414734, PubMed:15132997, PubMed:18415932, PubMed:20940257, PubMed:28263186). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:9119111, PubMed:10805756, PubMed:12414734, PubMed:15694126, PubMed:17525254, PubMed:26146088, PubMed:26150426, PubMed:26910618, PubMed:28263186). Also binds to some promoter regions (PubMed:20940257). Plays a central role in successive steps of chondrocyte differentiation (PubMed:11371614, PubMed:12414734, PubMed:22421045). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (PubMed:11371614, PubMed:12414734). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (PubMed:11371614, PubMed:12414734, PubMed:15529345). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (PubMed:22421045, PubMed:31121357). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (PubMed:21367821, PubMed:22421045). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (PubMed:32103177). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (PubMed:30021842). Acts in cooperation with the Hedgehog pathway- dependent GLI (GLI1 and GLI3) transcription factors (PubMed:29659575). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (PubMed:24191021). Controls epithelial branching during kidney development (PubMed:21212101). Homodimer; homodimerization is required for activity (PubMed:26146088). Interacts (via C-terminus) with ZNF219; forming a complex that binds to the COL2A1 promoter and activates COL2A1 expression (PubMed:20940257). Interacts with DDRGK1 (By similarity). Interacts with EP300/p300 (By similarity). Interacts with beta-catenin (CTNNB1); inhibiting CTNNB1 activity by competing with the binding sites of TCF/LEF within CTNNB1 (PubMed:15132997). Nucleus Expressed in the intestinal epithelium (at protein level) (PubMed:22510880). Expressed in progenitor cells in various organs, including chondroprogenitors, osteoprogenitors and preadipocytes, but is not expressed in most differentiated cell types such as osteoblasts and adipocytes, with the exception of chondrocytes (PubMed:16203988). Highly expressed in developing chondrogenic tissues (PubMed:9119111). Also expressed in some non-chondrogenic tissues such as notochord, otic vesicle and neural tube (PubMed:9119111). Predominantly expressed in mesenchymal condensations throughout the embryo before and during the deposition of cartilage (PubMed:7704017). Expressed in multipotent skeletogenic cells (PubMed:9119111). Continues to be expressed during chondrocyte lineage progression, except in terminally differentiating growth plate chondrocytes (PubMed:9119111). Also expressed in some non-chondrogenic tissues such as notochord, otic vesicle and neural tube (PubMed:9119111). In the developing lung, expressed at the distal tips of the branching epithelium as branching occurs and is down-regulated starting at embryonic day (E)16.5, at the onset of terminal differentiation of type 1 and type 2 alveolar cells (PubMed:24191021). Upon lipid starvation conditions, expression is activated by FOXO (FOXO1 and FOXO3). The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. The PQA region (for proline, glutamine and alanine-rich) helps stabilize SOX9 and facilitates transactivation. It lacks intrinsic transactivation capability. Acetylated; acetylation impairs nuclear localization and ability to transactivate expression of target genes (PubMed:26910618). Deacetylated by SIRT1 (PubMed:26910618). Phosphorylation at Ser-64 and Ser-211 by PKA increases transcriptional activity and may help delay chondrocyte maturation downstream of PTHLH/PTHrP signaling (PubMed:10805756, PubMed:11120880). Phosphorylation at either Ser-64 or Ser-211 is required for sumoylation, but phosphorylation is not dependent on sumoylation (PubMed:29644115). Phosphorylated on tyrosine residues; tyrosine dephosphorylation by PTPN11/SHP2 blocks SOX9 phosphorylation by PKA and subsequent SUMOylation (PubMed:29644115). Sumoylated; phosphorylation at either Ser-64 or Ser-211 is required for sumoylation (PubMed:29644115). Sumoylation is induced by BMP signaling pathway (PubMed:29644115). Ubiquitinated; ubiquitination leads to proteasomal degradation and is negatively regulated by DDRGK1. Perinatal lethality, with cleft palate, as well as hypoplasia and bending of many skeletal structures derived from cartilage precursors (PubMed:11371614). Heterozygous mice die shortly after birth and display skeletal malformations caused by impaired precartilaginous condensations (PubMed:11371614). In embryonic day 12.5 dpc heterozygotes embryos, skeletal elements are smaller (PubMed:11371614, PubMed:11857796). In 14.5 dpc heterozygous embryos, bending of radius, ulna and tibia cartilages is already prominent (PubMed:11371614). Premature mineralization is observed in many bones, including vertebrae and some craniofacial bones in 18.5 dpc heterozygous embryos (PubMed:11371614). Conditional deletion in undifferentiated mesenchymal cells of limb buds before mesenchymal condensations results in a complete absence of both cartilage and bone, while markers for the different axes of limb development show a normal pattern of expression (PubMed:12414734). Conditional deletion in undifferentiated mesenchymal cells of limb buds after chondrogenic mesenchymal condensations causes a severe generalized chondrodysplasia, in which most prechondrocytes are arrested as condensed mesenchymal cells and do not undergo overt differentiation into chondrocytes (PubMed:12414734). Conditional deletion in differentiated growth plate chondrocytes results in severe dwarfism caused by shortened columnar zones in growth plates, leading to an absence of chondrocyte enlargement (PubMed:22421045). Conditional deletion in epithelial cells leads to severe branching defects in the lung (PubMed:24191021). negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development cartilage condensation ossification branching involved in ureteric bud morphogenesis cell fate specification epithelial to mesenchymal transition tissue homeostasis positive regulation of protein phosphorylation hair follicle development morphogenesis of an epithelium positive regulation of mesenchymal cell proliferation chondrocyte differentiation chondrocyte development negative regulation of immune system process heart valve development heart valve morphogenesis aortic valve morphogenesis heart valve formation endocardial cushion morphogenesis chondrocyte differentiation involved in endochondral bone morphogenesis chondrocyte hypertrophy DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex nucleosome assembly chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cytoskeleton organization signal transduction epidermal growth factor receptor signaling pathway Notch signaling pathway spermatogenesis central nervous system development heart development beta-catenin binding positive regulation of cell proliferation negative regulation of cell proliferation male gonad development regulation of gene expression regulation of cell cycle process positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration neural crest cell development neural crest cell fate specification positive regulation of phosphatidylinositol 3-kinase signaling male germ-line sex determination cAMP-mediated signaling cell differentiation regulation of cell adhesion extracellular matrix organization male sex determination negative regulation of ossification negative regulation of bone mineralization prostate gland development negative regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation mammary gland development notochord development otic vesicle formation endocrine pancreas development negative regulation of chondrocyte differentiation positive regulation of chondrocyte differentiation lacrimal gland development macromolecular complex protein kinase A catalytic subunit binding protein localization to nucleus somatic stem cell population maintenance enhancer binding intrahepatic bile duct development regulation of cell proliferation negative regulation of apoptotic process bHLH transcription factor binding protein kinase B signaling sequence-specific DNA binding transcription regulatory region DNA binding nuclear transcription factor complex cell fate commitment regulation of cell differentiation negative regulation of myoblast differentiation positive regulation of protein catabolic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of photoreceptor cell differentiation oligodendrocyte differentiation homeostasis of number of cells within a tissue positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation cartilage development Sertoli cell differentiation Sertoli cell development astrocyte fate commitment retina development in camera-type eye limb bud formation retinal rod cell differentiation endochondral bone morphogenesis epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation prostate gland morphogenesis epithelial cell proliferation involved in prostatic bud elongation bronchus cartilage development trachea cartilage development intestinal epithelial structure maintenance regulation of cell proliferation involved in tissue homeostasis positive regulation of cartilage development regulation of branching involved in lung morphogenesis morphogenesis of a branching epithelium lung smooth muscle development macromolecular complex assembly negative regulation of biomineral tissue development ERK1 and ERK2 cascade Harderian gland development cellular response to mechanical stimulus cellular response to retinoic acid cellular response to interleukin-1 cellular response to epidermal growth factor stimulus cellular response to heparin cellular response to transforming growth factor beta stimulus otic vesicle development cellular response to BMP stimulus renal vesicle induction metanephric tubule development ureter development ureter urothelium development ureter smooth muscle cell differentiation ureter morphogenesis metanephric nephron tubule formation negative regulation of canonical Wnt signaling pathway cochlea morphogenesis positive regulation of kidney development positive regulation of branching involved in ureteric bud morphogenesis anterior head development pre-mRNA intronic binding cell-cell adhesion positive regulation of extracellular matrix assembly negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of male gonad development positive regulation of cell proliferation involved in heart morphogenesis positive regulation of mesenchymal stem cell differentiation regulation of epithelial cell proliferation involved in lung morphogenesis negative regulation of mesenchymal cell apoptotic process uc007med.1 uc007med.2 uc007med.3 uc007med.4 
ENSMUST00000000594.9 C1d ENSMUST00000000594.9 C1D nuclear receptor co-repressor, transcript variant 1 (from RefSeq NM_020558.4) C1D_MOUSE ENSMUST00000000594.1 ENSMUST00000000594.2 ENSMUST00000000594.3 ENSMUST00000000594.4 ENSMUST00000000594.5 ENSMUST00000000594.6 ENSMUST00000000594.7 ENSMUST00000000594.8 NM_020558 O35473 Q5SWJ6 Q61368 Suncor uc007ice.1 uc007ice.2 uc007ice.3 Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). Monomer and homodimer. Interacts with EXOSC10; the interaction probably mediates the association with the nuclear form of the RNA exosome. The homodimeric form interacts with TSNAX following gamma- radiation. Interacts with RAC3 (By similarity). Interacts with NR1D1, THRA, THRB, NCOR1 and NCOR2. Nucleus Cytoplasm Nucleus, nucleolus Note=EXOSC10 is required for nucleolar localization. Colocalizes with TSNAX in the nucleus. Kidney, heart, brain, spleen, lung, testis, liver and small intestine. Up-regulated during adipocyte and myogenic differentiation. Phosphorylated by PRKDC. Belongs to the C1D family. maturation of 5.8S rRNA DNA binding transcription corepressor activity RNA binding protein binding nucleus nucleolus cytoplasm rRNA processing apoptotic process ligand-dependent nuclear receptor binding transcriptional repressor complex negative regulation of transcription, DNA-templated uc007ice.1 uc007ice.2 uc007ice.3 
ENSMUST00000000608.8 Gm2a ENSMUST00000000608.8 GM2 ganglioside activator protein (from RefSeq NM_010299.3) ENSMUST00000000608.1 ENSMUST00000000608.2 ENSMUST00000000608.3 ENSMUST00000000608.4 ENSMUST00000000608.5 ENSMUST00000000608.6 ENSMUST00000000608.7 Gm2a NM_010299 Q60648 Q61610 Q61819 SAP3_MOUSE uc007iyw.1 uc007iyw.2 uc007iyw.3 uc007iyw.4 uc007iyw.5 Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Has cholesterol transfer activity (By similarity). Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747, ChEBI:CHEBI:16113; Evidence=; Lysosome. Widely expressed. Most abundant in kidney and testis. ganglioside metabolic process beta-N-acetylhexosaminidase activity lipid transporter activity cytoplasm mitochondrion lysosome lipid metabolic process sphingolipid metabolic process ganglioside catabolic process lipid transport learning or memory enzyme activator activity oligosaccharide catabolic process cytoplasmic side of plasma membrane phospholipase activator activity basolateral plasma membrane apical plasma membrane hydrolase activity lipid storage beta-N-acetylgalactosaminidase activity neurological system process neuromuscular process controlling balance positive regulation of hydrolase activity uc007iyw.1 uc007iyw.2 uc007iyw.3 uc007iyw.4 uc007iyw.5 
ENSMUST00000000641.15 Sema4f ENSMUST00000000641.15 sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain, transcript variant 1 (from RefSeq NM_011350.5) ENSMUST00000000641.1 ENSMUST00000000641.10 ENSMUST00000000641.11 ENSMUST00000000641.12 ENSMUST00000000641.13 ENSMUST00000000641.14 ENSMUST00000000641.2 ENSMUST00000000641.3 ENSMUST00000000641.4 ENSMUST00000000641.5 ENSMUST00000000641.6 ENSMUST00000000641.7 ENSMUST00000000641.8 ENSMUST00000000641.9 NM_011350 Q505G0 Q9R1Y1 Q9Z123 SEM4F_MOUSE Semaw uc012ent.1 uc012ent.2 uc012ent.3 This gene encodes a member of semaphorin family of membrane-bound and secreted proteins that are involved in guiding axonal growth. The encoded protein is a transmembrane protein localized to the glutamatergic synapses via its association with a synapse-associated scaffolding protein. In oligodendrocyte precursor cells, the encoded protein contributes to the outward migration and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]. Probable cell surface receptor that regulates oligodendroglial precursor cell migration (PubMed:21945643). Might also regulate differentiation of oligodendroglial precursor cells (By similarity). Has growth cone collapse activity against retinal ganglion-cell axons (By similarity). Interacts (via PDZ-binding motif) with DLG4/SAP90 (via PDZ domain 2); this interaction may promote translocation of DLG4/SAP90 to the membrane. Cell membrane ; Single-pass type I membrane protein Postsynaptic density Perikaryon Cell projection, dendrite Note=Colocalizes with DLG4 at synapses. Expressed throughout the adult brain, where it shows particularly strong expression in the hippocampus, corpus callosum, granular layer and deep nuclei of the cerebellum, and the mitral layer of the olfactory bulb (at protein level) (PubMed:21945643). At the cellular level, detected in neuronal precursors, postmitotic neurons, pyramidal neurons, and glial cells including mature oligodendocytes and oligodendroglial precursor cells (at protein level) (PubMed:21945643). During 14 dpc expression is abundant in the cerebral cortex, hippocampus, brain stem and the mitral and glomerular layers of the olfactory bulb, expression in the olfactory bulb remains evident into adulthood (at protein level) (PubMed:21945643). Expressed in proliferative layers and oligodendroglial precursor cells (OPCs) during embryonic development (14-16 dpc), in regions such as the ganglionic eminence, mamillothalamic tract, neuroepithelium, and cortical plate (at protein level) (PubMed:21945643). Expressed in migrating OPCs along the optic nerve at 16.5 dpc (at protein level) (PubMed:21945643). During late embryonic development (18 dpc) expression is abundant in pyramidal and granular cells of the hippocampus, and OPCs in the migratory pathway and embryonic fimbria of the hippocampus (at protein level) (PubMed:21945643). At postnatal day 1 (P1) expression is abundant in the corpus callosum, anterior commissure, and several nerve nuclei in the hindbrain, such as the oculomotor nucleus, the periaqueductal gray area, the facial nucleus, the colliculli, and the raphe and pararubral nuclei, as well as in the proliferative layers of the anterior subventricular zone, with expression remaining evident into adulthood (at protein level) (PubMed:21945643). A significant abundance of protein is apparent in the arcuate and posterior hypothalamic nuclei at P10, and additionally in hypothalamic OPCs, expression becomes evident in the arcuate nucleus at P15 (at protein level) (PubMed:21945643). Abundant expression throughout the embryonic brain from 14 dpc onwards with decreased expression in all areas of the brain in adulthood, however expression remains relatively abundant (PubMed:21945643). Belongs to the semaphorin family. neural crest cell migration protein binding extracellular space endoplasmic reticulum plasma membrane integral component of plasma membrane multicellular organism development nervous system development axon guidance postsynaptic density membrane integral component of membrane cell junction cell differentiation semaphorin receptor binding positive regulation of cell migration dendrite negative regulation of axon extension retinal ganglion cell axon guidance cell projection perikaryon synapse postsynaptic membrane chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway uc012ent.1 uc012ent.2 uc012ent.3 
ENSMUST00000000642.11 Hk2 ENSMUST00000000642.11 hexokinase 2 (from RefSeq NM_013820.4) ENSMUST00000000642.1 ENSMUST00000000642.10 ENSMUST00000000642.2 ENSMUST00000000642.3 ENSMUST00000000642.4 ENSMUST00000000642.5 ENSMUST00000000642.6 ENSMUST00000000642.7 ENSMUST00000000642.8 ENSMUST00000000642.9 HXK2_MOUSE Hk2 NM_013820 O08528 uc009cll.1 uc009cll.2 uc009cll.3 uc009cll.4 Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively) (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+); Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741; Evidence=; Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+); Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126; Evidence=; Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+); Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826; Evidence=; Hexokinase activity is specifically inhibited by 2,6-disubstituted glucosamines. Carbohydrate metabolism; hexose metabolism. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 1/4. Monomer (By similarity). Interacts with TIGAR; the interaction increases hexokinase activity in a hypoxia- and HIF1A-dependent manner (By similarity). Mitochondrion outer membrane ; Peripheral membrane protein Cytoplasm, cytosol Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane. The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein. Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis. Predominantly expressed in skeletal muscle, heart and adipose tissues. The N- and C-terminal halves of the protein contain a hexokinase domain. In contrast to hexokinase-1 and -3 (HK1 and HK3, respectively), both hexokinase domains display catalytic activity. The region connecting the two hexokinase domains is required for the catalytic activity of the N-terminal hexokinase domain. The N-terminal half regulates stability of the whole enzyme. Embryonic lethality around E7.5 stage probably caused by the absence of hexokinase activity. Belongs to the hexokinase family. nucleotide binding response to hypoxia cellular glucose homeostasis response to ischemia catalytic activity glucokinase activity hexokinase activity protein binding ATP binding glucose binding cytoplasm mitochondrion mitochondrial outer membrane cytosol plasma membrane carbohydrate metabolic process fructose 6-phosphate metabolic process glucose metabolic process glycolytic process lactation metabolic process apoptotic mitochondrial changes fructokinase activity membrane kinase activity phosphorylation sarcoplasmic reticulum transferase activity phosphotransferase activity, alcohol group as acceptor mannokinase activity hexose metabolic process negative regulation of mitochondrial membrane permeability positive regulation of angiogenesis regulation of glucose import carbohydrate phosphorylation glucose 6-phosphate metabolic process establishment of protein localization to mitochondrion maintenance of protein location in mitochondrion positive regulation of mitophagy in response to mitochondrial depolarization cellular response to leukemia inhibitory factor negative regulation of reactive oxygen species metabolic process uc009cll.1 uc009cll.2 uc009cll.3 uc009cll.4 
ENSMUST00000000687.9 Haao ENSMUST00000000687.9 3-hydroxyanthranilate 3,4-dioxygenase (from RefSeq NM_025325.2) 3HAO_MOUSE ENSMUST00000000687.1 ENSMUST00000000687.2 ENSMUST00000000687.3 ENSMUST00000000687.4 ENSMUST00000000687.5 ENSMUST00000000687.6 ENSMUST00000000687.7 ENSMUST00000000687.8 NM_025325 Q52L88 Q78JT3 uc008dsk.1 uc008dsk.2 uc008dsk.3 Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Reaction=3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde; Xref=Rhea:RHEA:17953, ChEBI:CHEBI:15379, ChEBI:CHEBI:36559, ChEBI:CHEBI:77612; EC=1.13.11.6; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. Monomer. Cytoplasm, cytosol No visible phenotype. Mice were born at the expected Mendelian ratio and are normal. They however show very high levels of 3-hydroxyanthranilate compared to wild-type mice. Belongs to the 3-HAO family. 3-hydroxyanthranilate 3,4-dioxygenase activity iron ion binding cytoplasm cytosol tryptophan catabolic process ferrous iron binding NAD biosynthetic process response to zinc ion oxidoreductase activity pyridine nucleotide biosynthetic process quinolinate biosynthetic process oxygen binding mitochondrial membrane 'de novo' NAD biosynthetic process from tryptophan anthranilate metabolic process response to cadmium ion metal ion binding quinolinate metabolic process dioxygenase activity oxidation-reduction process neuron cellular homeostasis uc008dsk.1 uc008dsk.2 uc008dsk.3 
ENSMUST00000000696.7 Cd52 ENSMUST00000000696.7 CD52 antigen (from RefSeq NM_013706.2) CD52_MOUSE Cdw52 ENSMUST00000000696.1 ENSMUST00000000696.2 ENSMUST00000000696.3 ENSMUST00000000696.4 ENSMUST00000000696.5 ENSMUST00000000696.6 Mb7 NM_013706 Q64389 uc008vea.1 uc008vea.2 uc008vea.3 uc008vea.4 May play a role in carrying and orienting carbohydrate, as well as having a more specific role. Cell membrane; Lipid-anchor, GPI-anchor. Expressed on lymphohematopoietic tissues, including thymus, spleen, and bone marrow, but not in liver, kidney, and brain. plasma membrane positive regulation of cytosolic calcium ion concentration response to bacterium membrane anchored component of membrane sperm midpiece uc008vea.1 uc008vea.2 uc008vea.3 uc008vea.4 
ENSMUST00000000707.9 Loxl3 ENSMUST00000000707.9 lysyl oxidase-like 3 (from RefSeq NM_013586.5) ENSMUST00000000707.1 ENSMUST00000000707.2 ENSMUST00000000707.3 ENSMUST00000000707.4 ENSMUST00000000707.5 ENSMUST00000000707.6 ENSMUST00000000707.7 ENSMUST00000000707.8 LOXL3_MOUSE Lor2 Loxl3 NM_013586 Q91VN8 Q9JJ39 Q9Z175 uc009clt.1 uc009clt.2 uc009clt.3 Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:26954549). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross- links between collagens and elastin (PubMed:26307084). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (PubMed:26954549). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T- cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (By similarity). Also able to catalyze deacetylation of lysine residues on STAT3 (By similarity). Reaction=H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl- [protein] + H2O2 + NH4(+); Xref=Rhea:RHEA:24544, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:12448, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:131803; EC=1.4.3.13; Evidence=; Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + O2 = (S)-2-amino-6- oxohexanoyl-[protein] + acetamide + H2O2; Xref=Rhea:RHEA:51648, Rhea:RHEA-COMP:10731, Rhea:RHEA-COMP:12448, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:27856, ChEBI:CHEBI:61930, ChEBI:CHEBI:131803; Evidence=; Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Name=lysine tyrosylquinone residue; Xref=ChEBI:CHEBI:20489; Evidence=; Note=Contains 1 lysine tyrosylquinone. ; Secreted, extracellular space Cytoplasm Nucleus Note=It is unclear how LOXL3 is both intracellular (cytoplasmic and nuclear) and extracellular: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, the intracellular location is clearly reported and at least another protein of the family (LOXL2) also has intracellular and extracellular localization despite the presence of a signal sequence. Expressed in palate: predominantly present in the palate mesenchyme and tongue (at protein level) (PubMed:26307084). In spine, expressed in the original intervertebral disk, cartilage primordia, anterior and posterior longitudinal ligaments, meninges of spinal cord, lung and heart (PubMed:26307084). In eyes, strongly expressed in the skin of the eyelid and weakly expressed in the cornea and sclera (PubMed:26307084). In lung, predominantly expressed in the pulmonary mesenchyme (PubMed:27645581). In developing muscle, expressed at myofiber ends (at protein level) (PubMed:26954549). The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Perinatal lethality, due to impaired development of the palate shelves and abnormalities in the cartilage primordia of the thoracic vertebrae (PubMed:26307084, PubMed:26954549). Cleft palates and spinal deformities are caused by the decreased collagen cross-links in the palate and spine (PubMed:26307084). In addition, mice display a reduction in the saccular space in the lungs at 18.5 dpc (PubMed:26307084, PubMed:27645581). Lungs also show reduced lung volumes and weights and deformed and smaller thoracic cavities (PubMed:27645581). Excess elastic fibers are detected, possibly due to an increased expression of Loxl4 (PubMed:27645581). Embryos show defects in the somitic boundaries, due to defects in myofibers that anchor prematurely or overshoot to adjacent somites, and lack tension (PubMed:26954549). Splenocytes show increased number of T-cells into T- helper Th17 cells and constitutive acetylation of Stat3 (PubMed:28065600). Belongs to the lysyl oxidase family. epithelial to mesenchymal transition fibronectin binding protein-lysine 6-oxidase activity scavenger receptor activity copper ion binding extracellular region extracellular space nucleus cytoplasm endocytosis inflammatory response membrane oxidoreductase activity oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor peptidyl-lysine oxidation spinal cord development collagen fibril organization lung development negative regulation of transcription, DNA-templated metal ion binding oxidation-reduction process palate development somite development fibronectin fibril organization negative regulation of T-helper 17 cell lineage commitment positive regulation of integrin-mediated signaling pathway uc009clt.1 uc009clt.2 uc009clt.3 
ENSMUST00000000717.9 Tcl1b5 ENSMUST00000000717.9 T cell leukemia/lymphoma 1B, 5, transcript variant 2 (from RefSeq NM_013776.2) ENSMUST00000000717.1 ENSMUST00000000717.2 ENSMUST00000000717.3 ENSMUST00000000717.4 ENSMUST00000000717.5 ENSMUST00000000717.6 ENSMUST00000000717.7 ENSMUST00000000717.8 NM_013776 Q3UT92 Q3UT92_MOUSE Tcl1b5 uc007oxy.1 uc007oxy.2 uc007oxy.3 Belongs to the TCL1 family. protein serine/threonine kinase activator activity positive regulation of protein serine/threonine kinase activity uc007oxy.1 uc007oxy.2 uc007oxy.3 
ENSMUST00000000724.15 Kat2b ENSMUST00000000724.15 K(lysine) acetyltransferase 2B, transcript variant 3 (from RefSeq NR_151733.1) ENSMUST00000000724.1 ENSMUST00000000724.10 ENSMUST00000000724.11 ENSMUST00000000724.12 ENSMUST00000000724.13 ENSMUST00000000724.14 ENSMUST00000000724.2 ENSMUST00000000724.3 ENSMUST00000000724.4 ENSMUST00000000724.5 ENSMUST00000000724.6 ENSMUST00000000724.7 ENSMUST00000000724.8 ENSMUST00000000724.9 KAT2B_MOUSE Kat2b NR_151733 Pcaf Q3U142 Q640M9 Q9JHD1 uc008czp.1 uc008czp.2 uc008czp.3 uc008czp.4 Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4. Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing. Acetylates MAPRE1/EB1, promoting dynamic kinetochore-microtubule interactions in early mitosis. Also acetylates spermidine. Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; Reaction=acetyl-CoA + spermidine = CoA + H(+) + N(8)-acetylspermidine; Xref=Rhea:RHEA:28270, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57834, ChEBI:CHEBI:58535; EC=2.3.1.57; Evidence=; Interacts with BCAS3. Interacts with SIRT1. Interacts with EP300, CREBBP and DDX17. Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4. Interacts with MECOM. Interacts with NR2C2 (hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2. Interacts with NFE4. Interacts with MECOM. Interacts with E2F1; the interaction acetylates E2F1 augmenting its DNA-binding and transcriptional activity. Interacts with NPAS2, BMAL1 and CLOCK (By similarity). Interacts (unsumoylated form) with NR2C1; the interaction promotes transactivation activity. Interacts with CEBPB (By similarity). Interacts with NR4A3 (PubMed:12709428). Interacts with TBX5 (By similarity). Interacts with PLK4 (By similarity). Interacts with RB1; this interaction leads to RB1 acetylation (PubMed:20940255). Q9JHD1; Q505F1: Nr2c1; NbExp=3; IntAct=EBI-2325611, EBI-15617004; Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Mainly localizes to the nucleus. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation. Localizes to sites of DNA damage. Expression is low during embryogenesis and becomes up-regulated in some adult tissues including heart and skeletal muscle. No visible phenotype (PubMed:11017084). Belongs to the acetyltransferase family. GCN5 subfamily. histone acetyltransferase complex kinetochore nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding chromatin binding transcription cofactor activity transcription coactivator activity diamine N-acetyltransferase activity histone acetyltransferase activity lysine N-acetyltransferase activity, acting on acetyl phosphate as donor cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding nucleus nucleoplasm Ada2/Gcn5/Ada3 transcription activator complex cytoplasm centrosome microtubule organizing center cytosol cytoskeleton chromatin remodeling regulation of transcription, DNA-templated protein acetylation cell cycle heart development N-acetyltransferase activity transcription factor binding negative regulation of cell proliferation regulation of protein ADP-ribosylation positive regulation of neuron projection development acetyltransferase activity histone acetylation transferase activity transferase activity, transferring acyl groups N-terminal peptidyl-lysine acetylation internal peptidyl-lysine acetylation peptidyl-lysine acetylation protein kinase binding A band I band cellular response to insulin stimulus macromolecular complex histone acetyltransferase binding positive regulation of chromatin binding positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter actomyosin histone deacetylase binding histone H3 acetylation histone H3-K9 acetylation negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of centriole replication rhythmic process limb development peptide-lysine-N-acetyltransferase activity positive regulation of histone H3-K14 acetylation positive regulation of histone H3-K9 acetylation uc008czp.1 uc008czp.2 uc008czp.3 uc008czp.4 
ENSMUST00000000727.4 Rab5b ENSMUST00000000727.4 RAB5B, member RAS oncogene family (from RefSeq NM_177411.4) ENSMUST00000000727.1 ENSMUST00000000727.2 ENSMUST00000000727.3 NM_177411 P35239 P35277 P61021 RAB5B_MOUSE uc007hnv.1 uc007hnv.2 uc007hnv.3 uc007hnv.4 uc007hnv.5 Protein transport (By similarity). Probably involved in vesicular traffic (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Binds EEA1. Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs (By similarity). Interacts with GDI1, GDI2, CHML and CHM; phosphorylation at Ser-84 disrupts this interaction (By similarity). P61021; Q5S007: LRRK2; Xeno; NbExp=2; IntAct=EBI-8320093, EBI-5323863; Cell membrane ; Lipid-anchor ; Cytoplasmic side Early endosome membrane ; Lipid-anchor Melanosome Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity protein binding GTP binding endosome early endosome plasma membrane intracellular protein transport endocytosis endosome organization protein transport membrane GDP binding antigen processing and presentation regulation of endocytosis endocytic vesicle GTP-dependent protein binding early endosome membrane Rab protein signal transduction melanosome intracellular membrane-bounded organelle plasma membrane to endosome transport extracellular exosome anchored component of synaptic vesicle membrane uc007hnv.1 uc007hnv.2 uc007hnv.3 uc007hnv.4 uc007hnv.5 
ENSMUST00000000755.15 Sult5a1 ENSMUST00000000755.15 sulfotransferase family 5A, member 1 (from RefSeq NM_020564.3) ENSMUST00000000755.1 ENSMUST00000000755.10 ENSMUST00000000755.11 ENSMUST00000000755.12 ENSMUST00000000755.13 ENSMUST00000000755.14 ENSMUST00000000755.2 ENSMUST00000000755.3 ENSMUST00000000755.4 ENSMUST00000000755.5 ENSMUST00000000755.6 ENSMUST00000000755.7 ENSMUST00000000755.8 ENSMUST00000000755.9 NM_020564 Q91X36 Q91X36_MOUSE Sult5a1 uc009nuh.1 uc009nuh.2 uc009nuh.3 uc009nuh.4 Belongs to the sulfotransferase 1 family. molecular_function cellular_component sulfotransferase activity biological_process transferase activity uc009nuh.1 uc009nuh.2 uc009nuh.3 uc009nuh.4 
ENSMUST00000000756.6 Rpl13 ENSMUST00000000756.6 ribosomal protein L13 (from RefSeq NM_016738.5) ENSMUST00000000756.1 ENSMUST00000000756.2 ENSMUST00000000756.3 ENSMUST00000000756.4 ENSMUST00000000756.5 NM_016738 P47963 Q9CRZ9 Q9DCH1 RL13_MOUSE uc009nue.1 uc009nue.2 uc009nue.3 uc009nue.4 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Cytoplasm Belongs to the eukaryotic ribosomal protein eL13 family. structural constituent of ribosome nucleolus endoplasmic reticulum cytosol ribosome translation cytosolic large ribosomal subunit uc009nue.1 uc009nue.2 uc009nue.3 uc009nue.4 
ENSMUST00000000759.9 Chmp1a ENSMUST00000000759.9 charged multivesicular body protein 1A (from RefSeq NM_145606.3) CHM1A_MOUSE Chmp1 ENSMUST00000000759.1 ENSMUST00000000759.2 ENSMUST00000000759.3 ENSMUST00000000759.4 ENSMUST00000000759.5 ENSMUST00000000759.6 ENSMUST00000000759.7 ENSMUST00000000759.8 NM_145606 Pcoln3 Q3TW57 Q921W0 uc009nuk.1 uc009nuk.2 uc009nuk.3 uc009nuk.4 Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing (By similarity). Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Self-associates. Interacts with CHMP1B. Interacts with VPS4A. Interacts with VPS4B. Interacts with PHF1. Interacts with IST1. Interacts with MITD1 (By similarity). Cytoplasm Endosome membrane ; Peripheral membrane protein Nucleus matrix Note=The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin. Highly expressed in adult heart, kidney and liver. Expressed at lower levels in adult colon, spleen, lung, brain, testis and muscle. Also expressed in myoblasts and embryo fibroblasts. Belongs to the SNF7 family. condensed nuclear chromosome ESCRT III complex protein binding nucleus cytoplasm endosome early endosome multivesicular body microtubule organizing center nucleus organization vacuolar transport cell cycle mitotic chromosome condensation mitotic metaphase plate congression endosome membrane regulation of centrosome duplication endomembrane system protein transport membrane vesicle-mediated transport nuclear matrix gene silencing protein domain specific binding endosome transport via multivesicular body sorting pathway identical protein binding protein homodimerization activity late endosome to vacuole transport negative regulation of cell cycle negative regulation of transcription, DNA-templated cell division regulation of mitotic spindle assembly uc009nuk.1 uc009nuk.2 uc009nuk.3 uc009nuk.4 
ENSMUST00000000769.14 Serpinf1 ENSMUST00000000769.14 serine (or cysteine) peptidase inhibitor, clade F, member 1 (from RefSeq NM_011340.3) ENSMUST00000000769.1 ENSMUST00000000769.10 ENSMUST00000000769.11 ENSMUST00000000769.12 ENSMUST00000000769.13 ENSMUST00000000769.2 ENSMUST00000000769.3 ENSMUST00000000769.4 ENSMUST00000000769.5 ENSMUST00000000769.6 ENSMUST00000000769.7 ENSMUST00000000769.8 ENSMUST00000000769.9 NM_011340 O70629 O88691 P97298 PEDF_MOUSE Pedf Sdf3 uc007kdp.1 uc007kdp.2 uc007kdp.3 Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Interacts with PNPLA2; this interaction stimulates the phospholipase A2 activity of PNPLA2. Secreted. Melanosome Highly expressed in the liver, gastric glandular mucosa and renal tubules. It is also expressed in the brain, heart, lung retina and testes. First detected at 12.5 dpc in cartilage primordium, it is present in the osseous matrix of developing limbs, vertebrae, ribs and skull. At 16.5 dpc it is detected in bone matrix and smooth muscle, and at lower levels in connective tissue, bronchial epithelial cells, metanephron microtubules, and skin. Belongs to the serpin family. kidney development serine-type endopeptidase inhibitor activity extracellular region basement membrane extracellular space aging short-term memory response to acidic pH negative regulation of endothelial cell migration negative regulation of gene expression negative regulation of endopeptidase activity positive regulation of neuron projection development negative regulation of angiogenesis axon melanosome ovulation cycle neuronal cell body axon hillock response to arsenic-containing substance perinuclear region of cytoplasm negative regulation of inflammatory response positive regulation of neurogenesis retina development in camera-type eye negative regulation of epithelial cell proliferation involved in prostate gland development cellular response to cobalt ion cellular response to retinoic acid cellular response to glucose stimulus cellular response to dexamethasone stimulus negative regulation of neuron death uc007kdp.1 uc007kdp.2 uc007kdp.3 
ENSMUST00000000776.15 Tubgcp3 ENSMUST00000000776.15 tubulin, gamma complex component 3 (from RefSeq NM_198031.1) ENSMUST00000000776.1 ENSMUST00000000776.10 ENSMUST00000000776.11 ENSMUST00000000776.12 ENSMUST00000000776.13 ENSMUST00000000776.14 ENSMUST00000000776.2 ENSMUST00000000776.3 ENSMUST00000000776.4 ENSMUST00000000776.5 ENSMUST00000000776.6 ENSMUST00000000776.7 ENSMUST00000000776.8 ENSMUST00000000776.9 GCP3_MOUSE Gcp3 NM_198031 P58854 Q6PDQ9 uc009kwd.1 uc009kwd.2 uc009kwd.3 Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 (By similarity). Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBTUBGCP3 and CDK5RAP2 (By similarity). Interacts with NIN (via N- terminus); the interaction may promote recruitment of the gamma-tubulin ring complex to the centrosome (PubMed:15784680). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Belongs to the TUBGCP family. microtubule cytoskeleton organization mitotic cell cycle spindle pole equatorial microtubule organizing center gamma-tubulin complex cytoplasm centrosome centriole microtubule organizing center polar microtubule cytoskeleton microtubule microtubule nucleation gamma-tubulin small complex cytoplasmic microtubule organization gamma-tubulin binding spindle assembly meiotic cell cycle interphase microtubule nucleation by interphase microtubule organizing center microtubule minus-end binding uc009kwd.1 uc009kwd.2 uc009kwd.3 
ENSMUST00000000793.13 Polr3d ENSMUST00000000793.13 polymerase (RNA) III (DNA directed) polypeptide D, transcript variant 1 (from RefSeq NM_025945.3) Bn51t ENSMUST00000000793.1 ENSMUST00000000793.10 ENSMUST00000000793.11 ENSMUST00000000793.12 ENSMUST00000000793.2 ENSMUST00000000793.3 ENSMUST00000000793.4 ENSMUST00000000793.5 ENSMUST00000000793.6 ENSMUST00000000793.7 ENSMUST00000000793.8 ENSMUST00000000793.9 NM_025945 Polr3d Q3U0T3 Q91WD1 Q9CZ02 RPC4_MOUSE uc007unz.1 uc007unz.2 uc007unz.3 uc007unz.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein- Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity). Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3- POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Nucleus Sumoylation on Lys-141 can serve as a signal to mark misfolded Pol III for proteasomal degradation. Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family. nuclear chromatin immune system process DNA binding chromatin binding DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm DNA-directed RNA polymerase III complex cytosol transcription from RNA polymerase III promoter nuclear speck positive regulation of interferon-beta production innate immune response positive regulation of innate immune response defense response to virus RNA polymerase III activity uc007unz.1 uc007unz.2 uc007unz.3 uc007unz.4 
ENSMUST00000000804.7 Ddx3x ENSMUST00000000804.7 DEAD box helicase 3, X-linked (from RefSeq NM_010028.3) D1Pas1-rs2 DDX3X_MOUSE Ddx3 Dead3 ENSMUST00000000804.1 ENSMUST00000000804.2 ENSMUST00000000804.3 ENSMUST00000000804.4 ENSMUST00000000804.5 ENSMUST00000000804.6 Erh NM_010028 O09060 O09143 Q62167 uc009srl.1 uc009srl.2 uc009srl.3 uc009srl.4 Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in transcription regulation. Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity. CDKN1A up-regulation may be cell-type specific. Binds CDH1/E-cadherin promoter and represses its transcription. Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis. May positively regulate TP53 transcription. Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC). Involved in the regulation of translation initiation. Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR). This function depends on helicase activity. Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning. Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety. Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process. Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle. May activate TP53 translation. Required for endoplasmic reticulum stress-induced ATF4 mRNA translation. Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E. Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E. Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (By similarity). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:30475900). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation. Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK- mediated activatory phosphorylation of IRF7. Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling. Negatively regulates TNF- induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm. May also bind IFNB promoter; the function is independent of IRF3 (By similarity). Involved in both stress and inflammatory responses (PubMed:31511697). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (By similarity). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity. Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (PubMed:31511697). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation. Cleavage by caspases may inactivate DDX3X and relieve the inhibition. Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant. ATPase and casein kinase- activating functions are mutually exclusive. May be involved in mitotic chromosome segregation (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Homodimer; can bind RNA as a monomer and as a dimer/oligomer. Interacts with TDRD3. When phosphorylated, interacts with IRF3; the interaction facilitates the phosphorylation and activation of IRF3 by IKBKE. Directly interacts with XPO1/CRM1. The interaction with XPO1/CMR1 is dependent on the DDX3X nuclear export signal motif and XPO1 interaction with GTPase RAN in its active GTP-bound form. Weakly interacts with TBKBP1/SINTBAD. Directly interacts with TRAF3; this interaction stimulates TRAF3 'Lys-63' ubiquitination. Interacts with CSNK1E in a Wnt-dependent manner; this interaction greatly enhances CSNK1E affinity for ATP, stimulates its kinase activity and promotes CSNK1E-mediated DVL2 phosphorylation. In the presence of RNA, the interaction is decreased. Also interacts with CSNK1D and stimulates its kinase activity. Interacts with TRPV4; this interaction is decreased when the TRPV4 channel is activated, leading to DDX3X relocalization to the nucleus. Interacts with MAP3K14/NIK. Directly interacts with CHUK/IKKA after physiological activation of the TLR7 and TLR8 pathways; this interaction enhances CHUK autophosphorylation. May associate with EIF4F complex, composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Directly interacts with EIF4E in an RNA-independent manner; this interaction enhances EIF4E cap-binding ability. Directly interacts with EIF4G1 in an RNA-independent manner. DDX3X competes with EIF4G1 for interaction with EIF4E. Interacts with EIF4A1 and EIF2S1 in an RNA- independent manner. Associates with the eukaryotic translation initiation factor 3 (eIF-3) complex, including with EIF3B and EIF3C subunits. Directly interacts with IKBKE/IKKE; this interaction stimulates IKBKE activating autophosphorylation and is induced upon viral infection. Interacts with TBK1. Interacts with SP1; this interaction potentiates SP1-induced CDKN1A/WAF1/CIP1 transcription. Interacts with GSK3A and GSK3B. Interacts with several death receptors, inclusing FAS, TNFRSF10A and TNFRSF10B. Recruited to TNFRSF10B in the absence of receptor stimulation. When TNFRSF10B is stimulated, further recruited to the receptor and cleaved by caspases. A large proteolytic fragment remains associated with TNFRSF10B. Interacts (via C-terminus) with NXF1/TAP; this interaction may be partly involved in DDX3X nuclear export and in NXF1 localization to stress granules. Identified in an mRNP complex, composed of at least DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1/2, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. The interaction with IGF2BP1/2 is RNA-dependent. Directly interacts with PABPC1/PABP1 in an RNA-independent manner. This interaction increases in stressed cells and decreases during cell recovery. Interacts (via C-terminus) with MAVS/IPS-1; this interaction potentiates MAVS-mediated IFNB induction. Interacts with ERCC6/CBS. Interacts with DHX33 in an RNA-independent manner. Interacts with DDX5 in the cytoplasm; this interaction may be more efficient when both proteins are unphosphorylated. Interacts with RIGI. Interacts with IFIH1/MDA5. Interacts with NCAPH; this interaction may be important for the NCAPH localization at condensing chromosomes during mitosis (By similarity). Interacts with NLRP3 (via NACHT domain) under inflammasome-activating conditions (PubMed:31511697). Interacts with CAPRIN1. Interacts with HNF4A and NR0B2/SHP in an RNA-independent manner; this interaction disrupts the interaction between HNF4 and NR0B2 that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. Interacts with CREBBP/CBP. Interacts with EP300/p300. Interacts with gamma-tubulin. Interacts with phosphorylated TP53. Directly interacts with RELA/p65; this interaction may trap RELA in the cytoplasm, impairing nuclear relocalization upon TNF activating signals (By similarity). Q62167; Q9UHD2: TBK1; Xeno; NbExp=8; IntAct=EBI-773173, EBI-356402; Cell membrane Nucleus Cytoplasm Cytoplasm, Stress granule Inflammasome Cell projection, lamellipodium Note=Shuttles between the nucleus and the cytosol. Exported from the nucleus partly through the XPO1/CRM1 system and partly through NXF1/TAP. Localizes to nuclear pores on the outer side of the nuclear membrane. In the cytosol, partly colocalizes with mitochondria. At G0, predominantly located in nucleus. In G1/S phase, predominantly cytoplasmic. During prophase/prometaphase, localizes in close proximity to the condensing chromosomes. During telophase, localizes around the newly synthesized nuclear membrane and in the cytoplasm. Colocalizes with TRPV4 at the plasma membrane. When TRPV4 channel is activated, intracellular Ca(2+) levels increase and the calmodulin/CAMKII pathway is activated, relocalizes to the nucleus. WNT3A stimulation promotes DDX3 recruitment to the plasma membrane. Expressed in ovary, including in germinal vesicle immature and metaphase II (MII) stage oocytes (at protein level) (PubMed:8948440, PubMed:25050112). In the brain, expressed in the granule cells of the cerebellum and dentate gyrus, the pyramidal cells of the hippocampus, the ependymal cells lining the ventricles, choroid plexi and olfactory bulb. Also accumulates in the thalamic nuclei, the dorsal region of the colliculi and the pontine nucleus (PubMed:8948440). In oocytes, expression levels increase from germinal vesicle immature oocytes to metaphase II (MII) and decline after fertilization in 1-cell and 2-cell embryos (at protein level) (PubMed:25050112). At 7.5 dpc, highly expressed in all embryonic cells and extraembryonic tissues, including ectoplacental cone, chorion, extraembryonic endoderm and parietal endoderm (at protein level) (PubMed:27179789). At 8.5-9.5 dpc, widely expressed (PubMed:8948440). At 8.5 dpc, levels decrease in extraembryonic tissues (PubMed:27179789). As development proceeds, expression becomes more restricted. At 11.5 dpc, most abundant in the neural tube, but still expressed at moderate levels in a number of other sites, including the mesenchyme of limbs and the face and in liver. At 14.5 dpc, highly expressed in the developing brain and caudal neural tube, but absent from the marginal layer of the neural tube. Also expressed in the developing metanephros and lung. At 15.5 dpc, expressed in the brain and spinal cord, as well as in teeth primordia, the lung and in the developing limb (PubMed:8948440). At 16.5 dpc, moderate, but non- uniform expression levels in the placenta (PubMed:27179789). The C-terminus (residues 536-662) is dispensable for DDX3X trafficking. Phosphorylated by TBK1; the phosphorylation is required for the synergistic induction of IFNB mediated by TBK1 and DDX3X. Phosphorylated by IKBKE. Also phosphorylated by CSNK1E; this phosphorylation may inhibit RNA-stimulated ATPase activity. Upon stimulation of death receptors, including TNFRSF10B, recruited to receptors and cleaved by caspases. Proteolytic fragments remain associated with the receptors. This cleavage presumably inactivates DDX3X anti-apoptotic function. In mutant males, loss of DDX3X leads to early post-implantation lethality. In mutant females with a maternally inherited Ddx3x null allele, paternal X chromosome inactivation affects trophoblast differentiation, which leads to aberrant placental layers and defective vascularization in placental labyrinth. These placental abnormalities impair maternal blood supply to the embryo and ultimately lead to fetal growth restriction and lethality. Heterozygous females with a paternally inherited null allele are born at the expected Mendelian ratio, develop normally and are indistinguishable from their littermate controls (PubMed:27179789). Epiblast-specific knockout embryos exhibit multiple anomalies, including defective neural tube closure, underdeveloped brain, poorly developed myocardial trabeculae, which ultimately lead to embryonic lethality around 11.5 dpc (PubMed:27179789). DDX3X and DDX3Y double knockout is embryonic lethal (PubMed:30613052). DDX3X and DDX3Y double knockout germ cells can differentiate into spermatozoa (PubMed:30613052). Bone-marrow macrophage-specific knockout leads to a reduction in the expression of several cytokines, including IL1B, IL6, IL12 and IFNB1, in response to Listeria monocytogenes infection and pathogen-associated molecular patterns (PAMPs), including poly (I:C), poly (dA:dT) and LPS. This effect is more prononced in females than in male macrophages, probably due to the functional redundancy with DDX3Y gene located on chromosome Y (PubMed:30475900). Encoded by an chromosome X-linked gene which escapes X chromosome inactivation (XCI) in females, but exhibits developmental- and tissue-specific differences in escape from XCI. DDX3Y, its homolog on chromosome Y, is located in the Y non-recombinant portion (By similarity). In 8 to 16 cell stage embryos, expression from paternal and maternal copies of DDX3X is detected. Paternally derived DDX3X is preferentially inactivated in extraembryonic tissues of embryos from 6.5 dpc (PubMed:27179789). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. The role of the nuclear export signal (NES) motif in XPO1- mediated DDX3X export is controversial (By similarity). In one study, NES has been found dispensable for DDX3X export while the helicase domain mediates the interaction with XPO1 (By similarity). However, in two other studies, DDX3X nuclear export is dependent on both NES and Ran in its GTP-bound form while the helicase domain is not required (By similarity). nucleotide binding immune system process nucleic acid binding DNA binding DNA helicase activity RNA binding RNA helicase activity GTPase activity helicase activity protein binding ATP binding nucleus cytoplasm mitochondrion mitochondrial outer membrane cytosol translational initiation regulation of translation apoptotic process chromosome segregation gamete generation transcription factor binding poly(A) binding eukaryotic initiation factor 4E binding extrinsic apoptotic signaling pathway via death domain receptors response to virus cytoplasmic stress granule RNA secondary structure unwinding positive regulation of gene expression membrane Wnt signaling pathway nuclear speck hydrolase activity ATPase activity nucleoside-triphosphatase activity negative regulation of translation cell differentiation positive regulation of cell growth negative regulation of cell growth negative regulation of protein complex assembly translation initiation factor binding DNA duplex unwinding RNA strand annealing activity stress granule assembly intracellular signal transduction RNA stem-loop binding ribosome biogenesis mature ribosome assembly ribosomal small subunit binding positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process P granule CTPase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein serine/threonine kinase activator activity positive regulation of viral genome replication innate immune response positive regulation of translation positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation mRNA 5'-UTR binding cellular response to arsenic-containing substance cellular response to osmotic stress positive regulation of protein serine/threonine kinase activity positive regulation of canonical Wnt signaling pathway intrinsic apoptotic signaling pathway positive regulation of G1/S transition of mitotic cell cycle protein localization to cytoplasmic stress granule negative regulation of intrinsic apoptotic signaling pathway eukaryotic translation initiation factor 3 complex cytosolic small ribosomal subunit uc009srl.1 uc009srl.2 uc009srl.3 uc009srl.4 
ENSMUST00000000809.3 Slc5a5 ENSMUST00000000809.3 solute carrier family 5 (sodium iodide symporter), member 5 (from RefSeq NM_053248.2) ENSMUST00000000809.1 ENSMUST00000000809.2 G3X8P5 G3X8P5_MOUSE NM_053248 Slc5a5 uc009mbz.1 uc009mbz.2 uc009mbz.3 Reaction=iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71207, ChEBI:CHEBI:16382, ChEBI:CHEBI:29101; Evidence=; Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. nucleus thyroid hormone generation sodium:iodide symporter activity iodide transmembrane transporter activity iodide transport membrane integral component of membrane transmembrane transporter activity transmembrane transport cellular response to cAMP cellular response to gonadotropin stimulus uc009mbz.1 uc009mbz.2 uc009mbz.3 
ENSMUST00000000811.8 Kcnn3 ENSMUST00000000811.8 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (from RefSeq NM_080466.2) ENSMUST00000000811.1 ENSMUST00000000811.2 ENSMUST00000000811.3 ENSMUST00000000811.4 ENSMUST00000000811.5 ENSMUST00000000811.6 ENSMUST00000000811.7 KCNN3_MOUSE NM_080466 P58391 Q3UUY9 Sk3 uc012cso.1 uc012cso.2 uc012cso.3 Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:11557517). Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity). Inhibited by bee venom neurotoxin apamin. Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity). Interacts with CALM1 (By similarity). Membrane; Multi-pass membrane protein. Expressed at low levels in atrial and ventricular myocytes (at protein level). Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily. calmodulin binding cytoplasm plasma membrane ion transport potassium ion transport calcium-activated potassium channel activity membrane integral component of membrane small conductance calcium-activated potassium channel activity filopodium neuromuscular junction neuron projection neuronal cell body cell body protein heterodimerization activity potassium ion transmembrane transport uc012cso.1 uc012cso.2 uc012cso.3 
ENSMUST00000000828.14 Txnrd3 ENSMUST00000000828.14 thioredoxin reductase 3, transcript variant 1 (from RefSeq NM_153162.3) ENSMUST00000000828.1 ENSMUST00000000828.10 ENSMUST00000000828.11 ENSMUST00000000828.12 ENSMUST00000000828.13 ENSMUST00000000828.2 ENSMUST00000000828.3 ENSMUST00000000828.4 ENSMUST00000000828.5 ENSMUST00000000828.6 ENSMUST00000000828.7 ENSMUST00000000828.8 ENSMUST00000000828.9 G3X8P6 G3X8P6_MOUSE NM_153162 Txnrd3 uc009cwj.1 uc009cwj.2 The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is evidence for additional isoforms resulting from the use of a non-AUG (CUG), and an in-frame downstream AUG as translation initiation codons (PMID:20018845). [provided by RefSeq, Aug 2017]. Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:20347; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Homodimer. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. nucleotide binding thioredoxin-disulfide reductase activity nucleoplasm cytosol electron carrier activity protein disulfide oxidoreductase activity oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor electron transport chain cell redox homeostasis flavin adenine dinucleotide binding oxidation-reduction process cellular oxidant detoxification uc009cwj.1 uc009cwj.2 
ENSMUST00000000834.4 Fasl ENSMUST00000000834.4 Fas ligand, transcript variant 1 (from RefSeq NM_010177.4) ENSMUST00000000834.1 ENSMUST00000000834.2 ENSMUST00000000834.3 Fasl NM_010177 Q544E9 Q544E9_MOUSE Tnlg1a uc007dfr.1 uc007dfr.2 uc007dfr.3 uc007dfr.4 uc007dfr.5 Cytoplasmic form induces gene transcription inhibition. Cytoplasmic vesicle lumen Lysosome lumen Membrane ; Single-pass type II membrane protein Nucleus Secreted Belongs to the tumor necrosis factor family. negative regulation of transcription from RNA polymerase II promoter death receptor binding cytokine activity tumor necrosis factor receptor binding extracellular region extracellular space nucleus plasma membrane caveola apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory cell apoptotic process immune response positive regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors membrane integral component of membrane negative regulation of angiogenesis cellular chloride ion homeostasis cytoplasmic vesicle response to lipopolysaccharide positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of neuron apoptotic process membrane raft positive regulation of epidermal growth factor receptor signaling pathway endosomal lumen acidification perinuclear region of cytoplasm extracellular exosome T cell apoptotic process necroptotic process response to growth factor apoptotic signaling pathway extrinsic apoptotic signaling pathway necroptotic signaling pathway calcium ion transport from endoplasmic reticulum to cytosol positive regulation of endothelial cell apoptotic process uc007dfr.1 uc007dfr.2 uc007dfr.3 uc007dfr.4 uc007dfr.5 
ENSMUST00000000889.7 Il4 ENSMUST00000000889.7 interleukin 4, transcript variant 1 (from RefSeq NM_021283.2) ENSMUST00000000889.1 ENSMUST00000000889.2 ENSMUST00000000889.3 ENSMUST00000000889.4 ENSMUST00000000889.5 ENSMUST00000000889.6 IL4_MOUSE Il-4 NM_021283 P07750 uc007iwq.1 uc007iwq.2 uc007iwq.3 uc007iwq.4 uc007iwq.5 Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses (PubMed:3083412). Induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). Enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes (By similarity). Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (PubMed:26416964). In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (PubMed:25772794, PubMed:28202615). Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6 (PubMed:8624821, PubMed:25847241). Interacts with IL4R. Interacts with IL13RA1. Secreted. Deletion mutant mice demonstrate anxiety-like behavior in comparison to WT mice (PubMed:25772794). In addition, they show impaired cognitive function (PubMed:28202615). Belongs to the IL-4/IL-13 family. microglial cell activation positive regulation of protein phosphorylation innate immune response in mucosa positive regulation of defense response to virus by host T-helper 1 cell lineage commitment positive regulation of immunoglobulin production negative regulation of acute inflammatory response negative regulation of chronic inflammatory response cytokine activity cytokine receptor binding interleukin-4 receptor binding extracellular region extracellular space autophagy immune response growth factor activity cholesterol metabolic process positive regulation of cell proliferation external side of plasma membrane regulation of proton transport positive regulation of gene expression negative regulation of epithelial cell migration positive regulation of macroautophagy positive regulation of B cell proliferation B cell costimulation positive regulation of interleukin-10 production positive regulation of interleukin-13 production T-helper 2 cell cytokine production positive regulation of T cell proliferation positive regulation of activated T cell proliferation T cell activation B cell activation positive regulation of tyrosine phosphorylation of STAT protein negative regulation of tumor necrosis factor biosynthetic process defense response to protozoan activation of Janus kinase activity myeloid dendritic cell differentiation negative regulation of macrophage activation positive regulation of mast cell degranulation negative regulation of nitric oxide biosynthetic process T-helper 2 cell differentiation positive regulation of chemokine biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of T cell differentiation negative regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of receptor-mediated endocytosis positive regulation of isotype switching to IgE isotypes positive regulation of isotype switching to IgG isotypes regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation regulation of immune response negative regulation of T cell activation positive regulation of B cell activation positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of white fat cell proliferation positive regulation of mononuclear cell migration dendritic cell differentiation extrinsic apoptotic signaling pathway in absence of ligand positive regulation of beta-amyloid clearance positive regulation of myoblast fusion positive regulation of cellular respiration positive regulation of reactive oxygen species biosynthetic process negative regulation of complement-dependent cytotoxicity negative regulation of T-helper 17 cell differentiation negative regulation of endothelial cell apoptotic process positive regulation of eosinophil chemotaxis positive regulation of ATP biosynthetic process negative regulation of extrinsic apoptotic signaling pathway uc007iwq.1 uc007iwq.2 uc007iwq.3 uc007iwq.4 uc007iwq.5 
ENSMUST00000000895.13 Necab3 ENSMUST00000000895.13 N-terminal EF-hand calcium binding protein 3, transcript variant 3 (from RefSeq NM_021546.3) A1L0S0 A1L0S1 A2AKE8 A2AKE9 Apba2bp ENSMUST00000000895.1 ENSMUST00000000895.10 ENSMUST00000000895.11 ENSMUST00000000895.12 ENSMUST00000000895.2 ENSMUST00000000895.3 ENSMUST00000000895.4 ENSMUST00000000895.5 ENSMUST00000000895.6 ENSMUST00000000895.7 ENSMUST00000000895.8 ENSMUST00000000895.9 NECA3_MOUSE NM_021546 Q3TYZ9 Q9D6J4 Q9ESR0 Xb51 uc008njh.1 uc008njh.2 uc008njh.3 Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta (By similarity). May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3 (By similarity). Interacts with the N-terminal domain of APBA2. Interacts with NEK2 (By similarity). Interacts with APBA3; APBA3 seems to mediate the interaction between NECAB3 and HIF1AN (By similarity). Golgi apparatus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D6J4-1; Sequence=Displayed; Name=2; IsoId=Q9D6J4-2; Sequence=VSP_000740; Widely expressed, with highest levels in the brain. Phosphorylated by NEK2. Sequence=AAI26875.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI26876.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB16414.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi cis cisterna calcium ion binding protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus protein metabolic process regulation of amyloid precursor protein biosynthetic process metal ion binding uc008njh.1 uc008njh.2 uc008njh.3 
ENSMUST00000000896.11 Pxmp4 ENSMUST00000000896.11 peroxisomal membrane protein 4, transcript variant 1 (from RefSeq NM_021534.4) ENSMUST00000000896.1 ENSMUST00000000896.10 ENSMUST00000000896.2 ENSMUST00000000896.3 ENSMUST00000000896.4 ENSMUST00000000896.5 ENSMUST00000000896.6 ENSMUST00000000896.7 ENSMUST00000000896.8 ENSMUST00000000896.9 NM_021534 PXMP4_MOUSE Pmp24 Q3U0L9 Q9CQV9 Q9JJW0 uc008njm.1 uc008njm.2 uc008njm.3 Interacts with PEX19. Peroxisome membrane ; Multi-pass membrane protein Belongs to the peroxisomal membrane protein PXMP2/4 family. molecular_function peroxisome peroxisomal membrane biological_process membrane integral component of membrane uc008njm.1 uc008njm.2 uc008njm.3 
ENSMUST00000000910.7 Dbh ENSMUST00000000910.7 dopamine beta hydroxylase (from RefSeq NM_138942.3) DOPO_MOUSE ENSMUST00000000910.1 ENSMUST00000000910.2 ENSMUST00000000910.3 ENSMUST00000000910.4 ENSMUST00000000910.5 ENSMUST00000000910.6 NM_138942 Q3V1U4 Q64237 uc008ixe.1 uc008ixe.2 uc008ixe.3 Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters. Reaction=dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical; Xref=Rhea:RHEA:19117, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:38290, ChEBI:CHEBI:59513, ChEBI:CHEBI:59905, ChEBI:CHEBI:72587; EC=1.14.17.1; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19118; Evidence=; Name=Cu(2+); Xref=ChEBI:CHEBI:29036; Evidence=; Note=Binds 2 copper ions per subunit. ; Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1. Homotetramer; composed of two disulfide-linked dimers. [Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass type II membrane protein Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane ; Single-pass type II membrane protein Detected in adrenal gland secretory granules (at protein level) (PubMed:7961964). Detected in adrenal gland (PubMed:1280432). Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form. N-glycosylated. Complete embryonic lethality in homozygous dams, and 88% embryonic lethality for homozygous embryos in heterozygous dams. Only 12% of the homozygous pups from heterozygous dams are alive at birth. Mutant pups have no obvious phenotype at birth, but nearly half of them die within 48 h, and only 5% survive to adulthood. Three weeks after birth, mutant pups are runted and weigh only half as much as their littermates. Still, the weight of adult males reaches 80% and that of females 88% of that of their littermates. Besides, mutant mice display ptosis. Embryonic lethality is due to a lack of noradrenaline and can be prevented by treatment with dihydroxyphenylserine, a compound that can be converted into noradrenaline in the absence of Dbh. Belongs to the copper type II ascorbate-dependent monooxygenase family. cytokine production blood vessel remodeling response to amphetamine leukocyte mediated immunity catalytic activity monooxygenase activity dopamine beta-monooxygenase activity copper ion binding extracellular space cytoplasm endoplasmic reticulum microtubule organizing center octopamine biosynthetic process memory locomotory behavior associative learning visual learning membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen axon dendrite transport vesicle membrane secretory granule membrane cytoplasmic vesicle L-ascorbic acid binding chromaffin granule lumen secretory granule lumen regulation of cell proliferation homoiothermy dopamine catabolic process norepinephrine biosynthetic process catecholamine biosynthetic process chromaffin granule membrane glucose homeostasis fear response maternal behavior neuronal cell body terminal bouton varicosity intracellular membrane-bounded organelle apical part of cell synapse positive regulation of vasoconstriction octopamine metabolic process metal ion binding behavioral response to ethanol response to pain leukocyte migration oxidation-reduction process regulation of extrinsic apoptotic signaling pathway uc008ixe.1 uc008ixe.2 uc008ixe.3 
ENSMUST00000000924.13 Mmp11 ENSMUST00000000924.13 matrix metallopeptidase 11, transcript variant 1 (from RefSeq NM_008606.3) ENSMUST00000000924.1 ENSMUST00000000924.10 ENSMUST00000000924.11 ENSMUST00000000924.12 ENSMUST00000000924.2 ENSMUST00000000924.3 ENSMUST00000000924.4 ENSMUST00000000924.5 ENSMUST00000000924.6 ENSMUST00000000924.7 ENSMUST00000000924.8 ENSMUST00000000924.9 Mmp11 NM_008606 Q3UQT3 Q3UQT3_MOUSE uc007fto.1 uc007fto.2 uc007fto.3 This gene encodes a member of the matrix metalloproteinase family of endopeptidases that are involved in remodeling extracellular matrix during, for example, embryonic development and tumor progression. The encoded protein undergoes post-translational proteolytic processing by furin endopeptidase to form an active enzyme. Subcutaneous introduction of cells expressing the encoded protein into nude mice results in increased tumor incidence. Mice lacking the encoded protein exhibit a decreased incidence of chemically-induced tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Can bind about 5 Ca(2+) ions per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. Belongs to the peptidase M10A family. metalloendopeptidase activity proteolysis multicellular organism development peptidase activity metallopeptidase activity zinc ion binding hydrolase activity extracellular matrix metal ion binding uc007fto.1 uc007fto.2 uc007fto.3 
ENSMUST00000000925.10 Smarcb1 ENSMUST00000000925.10 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1, transcript variant 1 (from RefSeq NM_011418.2) Baf47 ENSMUST00000000925.1 ENSMUST00000000925.2 ENSMUST00000000925.3 ENSMUST00000000925.4 ENSMUST00000000925.5 ENSMUST00000000925.6 ENSMUST00000000925.7 ENSMUST00000000925.8 ENSMUST00000000925.9 Ini1 NM_011418 Q9Z0H3 SNF5_MOUSE Snf5l1 uc007ftm.1 uc007ftm.2 uc007ftm.3 uc007ftm.4 Core component of the BAF (SWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (Probable). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (PubMed:17640523). Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (PubMed:26601204). Binds to double-stranded DNA. Interacts with CEBPB (when not methylated) (PubMed:20111005). Interacts with PIH1D1. Interacts with MYK and MAEL (PubMed:16787967). Interacts with PPP1R15A (By similarity). Interacts with DPF2 (By similarity). Interacts with YWHAZ (By similarity). Interacts with ERCC6 (By similarity). Interacts with FOS, FOSB isoform 1 and 2, FOSL1 and FOSL2 (PubMed:29272704). Q9Z0H3; P97496: Smarcc1; NbExp=5; IntAct=EBI-689365, EBI-648047; Nucleus. Event=Alternative splicing; Named isoforms=2; Name=A; Synonyms=INI1A; IsoId=Q9Z0H3-1; Sequence=Displayed; Name=B; Synonyms=INI1B; IsoId=Q9Z0H3-2; Sequence=VSP_004400; Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at 10.5 dpc-16.5 dpc. The N-terminal DNA-binding region is structurally similar to winged helix domains. Belongs to the SNF5 family. nuclear chromosome RNA polymerase I CORE element sequence-specific DNA binding RNA polymerase I transcriptional preinitiation complex assembly fibrillar center XY body blastocyst development blastocyst hatching p53 binding DNA binding transcription coactivator activity protein binding nucleus nucleoplasm nucleolus chromatin organization nucleosome disassembly chromatin remodeling regulation of transcription from RNA polymerase II promoter cell cycle nervous system development negative regulation of cell proliferation SWI/SNF complex cell differentiation Tat protein binding brahma complex single stranded viral RNA replication via double stranded DNA intermediate intracellular membrane-bounded organelle positive regulation by host of viral transcription positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity npBAF complex nBAF complex positive regulation of histone H4 acetylation negative regulation of histone H3-K9 dimethylation negative regulation of histone H3-K9 trimethylation positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter positive regulation of glucose mediated signaling pathway positive regulation of histone H3-K9 acetylation uc007ftm.1 uc007ftm.2 uc007ftm.3 uc007ftm.4 
ENSMUST00000000926.3 Vpreb3 ENSMUST00000000926.3 V-set pre-B cell surrogate light chain 3, transcript variant 1 (from RefSeq NM_009514.5) ENSMUST00000000926.1 ENSMUST00000000926.2 NM_009514 Q61243 Q61243_MOUSE Vpreb3 uc007ftt.1 uc007ftt.2 uc007ftt.3 immunoglobulin production molecular_function extracellular space endoplasmic reticulum immune response negative regulation of immunoglobulin secretion uc007ftt.1 uc007ftt.2 uc007ftt.3 
ENSMUST00000000939.15 Hip1r ENSMUST00000000939.15 huntingtin interacting protein 1 related, transcript variant 3 (from RefSeq NR_185273.1) ENSMUST00000000939.1 ENSMUST00000000939.10 ENSMUST00000000939.11 ENSMUST00000000939.12 ENSMUST00000000939.13 ENSMUST00000000939.14 ENSMUST00000000939.2 ENSMUST00000000939.3 ENSMUST00000000939.4 ENSMUST00000000939.5 ENSMUST00000000939.6 ENSMUST00000000939.7 ENSMUST00000000939.8 ENSMUST00000000939.9 HIP1R_MOUSE NR_185273 Q3UJ14 Q9JKY5 uc008zos.1 uc008zos.2 uc008zos.3 uc008zos.4 Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. Homodimer (PubMed:18790740). Interacts with actin; homodimerization promotes actin binding (PubMed:18790740). Interacts with CLTB (By similarity). Interacts with HIP1 (By similarity). Interacts (via ENTH and I/LWEQ domains) with BCL2L10 (By similarity). Q9JKY5; Q60598: Cttn; NbExp=4; IntAct=EBI-642457, EBI-397955; Q9JKY5; G3V6K6: Egfr; Xeno; NbExp=2; IntAct=EBI-642457, EBI-27088566; Q9JKY5; Q96B97: SH3KBP1; Xeno; NbExp=3; IntAct=EBI-642457, EBI-346595; Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region. Widely expressed. Expressed at lower levels in skeletal muscle and heart. The level of expression does not change appreciably during development. Binds F-actin via the talin-like I/LWEQ domain. Hip1 and Hip1r double knockout mice are dwarfed, afflicted with severe vertebral defects and die in early adulthood. Belongs to the SLA2 family. actin binding protein binding phospholipid binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm mitochondrion cytosol cytoskeleton clathrin-coated pit cell cortex endocytosis receptor-mediated endocytosis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process actin filament organization endomembrane system postsynaptic density membrane apical plasma membrane SH3 domain binding regulation of endocytosis clathrin-coated vesicle clathrin binding actin cortical patch clathrin-coated vesicle membrane negative regulation of actin filament polymerization cytoplasmic vesicle clathrin light chain binding positive regulation of protein binding ruffle membrane dendrite cytoplasm regulation of actin cytoskeleton organization negative regulation of Arp2/3 complex-mediated actin nucleation phosphatidylinositol binding clathrin adaptor activity identical protein binding protein homodimerization activity neuronal cell body positive regulation of apoptotic process negative regulation of apoptotic process dendritic spine intracellular membrane-bounded organelle phosphatidylinositol-3,4-bisphosphate binding positive regulation of epidermal growth factor receptor signaling pathway protein heterodimerization activity positive regulation of receptor-mediated endocytosis clathrin coat assembly perinuclear region of cytoplasm protein stabilization actin filament binding digestive system development regulation of gastric acid secretion membrane organization phosphatidylinositol-3,5-bisphosphate binding synaptic membrane positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway positive regulation of clathrin coat assembly regulation of clathrin-dependent endocytosis positive regulation of clathrin-dependent endocytosis positive regulation of platelet-derived growth factor receptor-beta signaling pathway uc008zos.1 uc008zos.2 uc008zos.3 uc008zos.4 
ENSMUST00000000940.15 Nsun5 ENSMUST00000000940.15 NOL1/NOP2/Sun domain family, member 5, transcript variant 3 (from RefSeq NR_153312.1) ENSMUST00000000940.1 ENSMUST00000000940.10 ENSMUST00000000940.11 ENSMUST00000000940.12 ENSMUST00000000940.13 ENSMUST00000000940.14 ENSMUST00000000940.2 ENSMUST00000000940.3 ENSMUST00000000940.4 ENSMUST00000000940.5 ENSMUST00000000940.6 ENSMUST00000000940.7 ENSMUST00000000940.8 ENSMUST00000000940.9 NR_153312 NSUN5_MOUSE Nsun5 Q3U0Q8 Q80WG3 Q8C568 Q8K4F6 Wbscr20a uc008zyh.1 uc008zyh.2 uc008zyh.3 S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3438 (m5C3438) in 28S rRNA (PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (By similarity). Required for corpus callosum and cerebral cortex development (PubMed:31174389, PubMed:31462248). Reaction=a cytidine in 28S rRNA + S-adenosyl-L-methionine = a 5- methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:47788, Rhea:RHEA-COMP:11915, Rhea:RHEA-COMP:11916, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47789; Evidence=; Nucleus, nucleolus In the hippocampus, specifically expressed in adult hippocampal NG2-positive oligodendrocyte precursor cells (at protein level). Present in the developing cerebral cortex from embryonic day 12.5 dpc, with a peak at 14.5 dpc followed by a decrease from 18.5 dpc (at protein level) (PubMed:31462248). Selectively expressed in radial glial cells of cerebral cortex from 12.5 to 16.5 dpc, but not in intermediate progenitor cells (IPCs) or neocortical neurons (at protein level) (PubMed:31462248). Highly expressed in callosal oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs) from postnatal day 7 to postnatal day 28 (PubMed:31174389). Decreased body weight and lean mass without alterations in food intake (PubMed:31722427). Adult mice show spatial cognitive deficits, possibly caused by defects in development and function of oligodendrocyte precursor cells (PubMed:30485550). Mice display a reduction of the corpus callosum with a decline in the number of myelinated axons and loose myelin sheath (PubMed:31174389). They also show impaired development of the cerebral cortex, characterized by impaired growth of radial glial scaffold (PubMed:31462248). Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. Sequence=AAH51209.1; Type=Erroneous initiation; Evidence=; RNA binding nucleus nucleolus rRNA processing methyltransferase activity transferase activity methylation rRNA base methylation uc008zyh.1 uc008zyh.2 uc008zyh.3 
ENSMUST00000000958.9 Top1mt ENSMUST00000000958.9 DNA topoisomerase 1, mitochondrial, transcript variant 1 (from RefSeq NM_028404.3) ENSMUST00000000958.1 ENSMUST00000000958.2 ENSMUST00000000958.3 ENSMUST00000000958.4 ENSMUST00000000958.5 ENSMUST00000000958.6 ENSMUST00000000958.7 ENSMUST00000000958.8 NM_028404 Q8R4U6 TOP1M_MOUSE uc007whb.1 uc007whb.2 uc007whb.3 Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Reaction=ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.; EC=5.6.2.1; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Divalent metal ions (calcium or magnesium). ; Mitochondrion Belongs to the type IB topoisomerase family. DNA binding DNA topoisomerase activity DNA topoisomerase type I activity nucleus chromosome mitochondrion DNA replication DNA topological change isomerase activity mitochondrial nucleoid uc007whb.1 uc007whb.2 uc007whb.3 
ENSMUST00000000964.6 Hoxa1 ENSMUST00000000964.6 homeobox A1, transcript variant 1 (from RefSeq NM_010449.5) B9EHK7 B9EHK7_MOUSE ENSMUST00000000964.1 ENSMUST00000000964.2 ENSMUST00000000964.3 ENSMUST00000000964.4 ENSMUST00000000964.5 Hoxa1 NM_010449 uc009bxy.1 uc009bxy.2 uc009bxy.3 Nucleus Belongs to the Antp homeobox family. Labial subfamily. DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc009bxy.1 uc009bxy.2 uc009bxy.3 
ENSMUST00000000985.7 Oxa1l ENSMUST00000000985.7 oxidase assembly 1-like (from RefSeq NM_026936.4) ENSMUST00000000985.1 ENSMUST00000000985.2 ENSMUST00000000985.3 ENSMUST00000000985.4 ENSMUST00000000985.5 ENSMUST00000000985.6 NM_026936 OXA1L_MOUSE Q8BGA9 Q8BK01 Q8R091 Q9D8X7 uc007tvu.1 uc007tvu.2 uc007tvu.3 Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria (By similarity). Monomer; predominantly monomeric at low salt concentrations. Homooligomer; predominantly homooligomeric at high salt concentrations. Homodimer. Homotetramer. Interacts with MRPL13, MRPL20, MRPL28, MRPL48, MRPL49 and MRPL51. Associates preferentially as a dimer with the large ribosomal subunit 39S of the mitochondrial ribosome (By similarity). Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the OXA1/ALB3/YidC family. mitochondrion mitochondrial inner membrane aerobic respiration membrane integral component of membrane integral component of mitochondrial inner membrane mitochondrial membrane integral component of mitochondrial membrane negative regulation of ATPase activity membrane insertase activity protein insertion into mitochondrial membrane from inner side mitochondrial respiratory chain complex I assembly macromolecular complex mitochondrial proton-transporting ATP synthase complex assembly mitochondrial respiratory chain complex IV assembly protein homodimerization activity protein insertion into membrane protein tetramerization negative regulation of oxidoreductase activity mitochondrial ribosome binding uc007tvu.1 uc007tvu.2 uc007tvu.3 
ENSMUST00000001002.8 Heatr6 ENSMUST00000001002.8 HEAT repeat containing 6 (from RefSeq NM_145432.3) ENSMUST00000001002.1 ENSMUST00000001002.2 ENSMUST00000001002.3 ENSMUST00000001002.4 ENSMUST00000001002.5 ENSMUST00000001002.6 ENSMUST00000001002.7 HEAT6_MOUSE NM_145432 Q3UUN8 Q6P1G0 Q99KZ5 Q9CSQ4 uc007kpu.1 uc007kpu.2 uc007kpu.3 Sequence=AAH03942.1; Type=Erroneous initiation; Evidence=; cellular_component biological_process uc007kpu.1 uc007kpu.2 uc007kpu.3 
ENSMUST00000001008.6 Ccl3 ENSMUST00000001008.6 C-C motif chemokine ligand 3 (from RefSeq NM_011337.2) Ccl3 ENSMUST00000001008.1 ENSMUST00000001008.2 ENSMUST00000001008.3 ENSMUST00000001008.4 ENSMUST00000001008.5 NM_011337 Q5QNW0 Q5QNW0_MOUSE uc007kpn.1 uc007kpn.2 uc007kpn.3 Secreted Belongs to the intercrine beta (chemokine CC) family. cytokine activity extracellular region extracellular space cell chemotaxis inflammatory response immune response signal transduction positive regulation of cytosolic calcium ion concentration chemokine activity neutrophil chemotaxis leukocyte chemotaxis response to drug positive regulation of osteoclast differentiation uc007kpn.1 uc007kpn.2 uc007kpn.3 
ENSMUST00000001009.14 Wfdc18 ENSMUST00000001009.14 WAP four-disulfide core domain 18 (from RefSeq NM_007969.4) ENSMUST00000001009.1 ENSMUST00000001009.10 ENSMUST00000001009.11 ENSMUST00000001009.12 ENSMUST00000001009.13 ENSMUST00000001009.2 ENSMUST00000001009.3 ENSMUST00000001009.4 ENSMUST00000001009.5 ENSMUST00000001009.6 ENSMUST00000001009.7 ENSMUST00000001009.8 ENSMUST00000001009.9 Expi NM_007969 P62810 Q62477 Q91VQ6 WFD18_MOUSE Wdnm1 uc007kpr.1 uc007kpr.2 uc007kpr.3 Could have proteinase inhibiting capacity. Secreted extracellular region negative regulation of peptidase activity peptidase inhibitor activity uc007kpr.1 uc007kpr.2 uc007kpr.3 
ENSMUST00000001027.7 Aox1 ENSMUST00000001027.7 aldehyde oxidase 1 (from RefSeq NM_009676.2) Aox1 ENSMUST00000001027.1 ENSMUST00000001027.2 ENSMUST00000001027.3 ENSMUST00000001027.4 ENSMUST00000001027.5 ENSMUST00000001027.6 G3X8P9 G3X8P9_MOUSE NM_009676 uc007bbl.1 uc007bbl.2 uc007bbl.3 Reaction=H2O + O2 + retinal = H(+) + H2O2 + retinoate; Xref=Rhea:RHEA:56736, ChEBI:CHEBI:15035, ChEBI:CHEBI:15036, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; Evidence=; Reaction=an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2; Xref=Rhea:RHEA:16829, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067; EC=1.2.3.1; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Evidence=; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. ; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 2 [2Fe-2S] clusters. ; Homodimer. Cytoplasm Belongs to the xanthine dehydrogenase family. aldehyde oxidase activity iron ion binding cytosol electron carrier activity oxidoreductase activity drug metabolic process electron transport chain identical protein binding protein homodimerization activity molybdopterin cofactor binding metal ion binding flavin adenine dinucleotide binding NAD binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding oxidation-reduction process FAD binding uc007bbl.1 uc007bbl.2 uc007bbl.3 
ENSMUST00000001040.7 Icam4 ENSMUST00000001040.7 intercellular adhesion molecule 4, Landsteiner-Wiener blood group, transcript variant 1 (from RefSeq NM_023892.3) ENSMUST00000001040.1 ENSMUST00000001040.2 ENSMUST00000001040.3 ENSMUST00000001040.4 ENSMUST00000001040.5 ENSMUST00000001040.6 ICAM4_MOUSE NM_023892 Q8K4L7 Q9CU00 Q9ERM2 uc009ojz.1 uc009ojz.2 uc009ojz.3 Adhesion molecule that binds to leukocyte adhesion LFA-1 protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins (By similarity). Isoform 2 may modulate binding of membrane-associated ICAM4. [Isoform 1]: Cell membrane ; Single-pass type I membrane protein [Isoform 2]: Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ERM2-1; Sequence=Displayed; Name=2; Synonyms=ICAM-4S; IsoId=Q9ERM2-2; Sequence=VSP_013464; Belongs to the immunoglobulin superfamily. ICAM family. integrin binding extracellular region extracellular space cytoplasm plasma membrane integral component of plasma membrane cell adhesion membrane integral component of membrane cell-cell adhesion uc009ojz.1 uc009ojz.2 uc009ojz.3 
ENSMUST00000001042.10 Ilf2 ENSMUST00000001042.10 interleukin enhancer binding factor 2 (from RefSeq NM_026374.3) ENSMUST00000001042.1 ENSMUST00000001042.2 ENSMUST00000001042.3 ENSMUST00000001042.4 ENSMUST00000001042.5 ENSMUST00000001042.6 ENSMUST00000001042.7 ENSMUST00000001042.8 ENSMUST00000001042.9 ILF2_MOUSE NM_026374 Nf45 Q3U083 Q5RKG0 Q8CCY9 Q99KS3 Q9CXY6 uc008qcj.1 uc008qcj.2 uc008qcj.3 Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:10574923). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2- mediated mRNA decay. Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71 (By similarity) (PubMed:10574923). Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1. Interacts with CRBN; this interaction promotes ubiquitination and subsequent degradation of ILF2. Nucleus, nucleolus Cytoplasm Nucleus Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in brain, kidney and ovary; highly expressed in testis, particularly within pachytene cells. Expression in testis begins with developmental differentiation of pachytene spermatocytes. Ubiquitinated at Lys-45 by CRBN with polyubiquitin chains by the CUL4-RING E3 ligase (CRL4-CRBN) and then degraded by the proteasome. Sequence=BAC27594.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; DNA binding RNA binding double-stranded RNA binding ATP binding nucleus nucleolus cytoplasm transcription, DNA-templated immune response transferase activity positive regulation of transcription, DNA-templated ribonucleoprotein complex uc008qcj.1 uc008qcj.2 uc008qcj.3 
ENSMUST00000001046.7 S100a4 ENSMUST00000001046.7 S100 calcium binding protein A4, transcript variant 1 (from RefSeq NM_011311.3) ENSMUST00000001046.1 ENSMUST00000001046.2 ENSMUST00000001046.3 ENSMUST00000001046.4 ENSMUST00000001046.5 ENSMUST00000001046.6 NM_011311 Q545V2 Q545V2_MOUSE S100a4 uc008qcz.1 uc008qcz.2 uc008qcz.3 uc008qcz.4 Cytoplasm Nucleus Secreted Belongs to the S-100 family. actin binding calcium ion binding nucleus identical protein binding neuron projection positive regulation of I-kappaB kinase/NF-kappaB signaling metal ion binding transition metal ion binding calcium-dependent protein binding perinuclear region of cytoplasm RAGE receptor binding uc008qcz.1 uc008qcz.2 uc008qcz.3 uc008qcz.4 
ENSMUST00000001051.9 S100a6 ENSMUST00000001051.9 S100 calcium binding protein A6 (calcyclin), transcript variant 1 (from RefSeq NM_011313.3) ENSMUST00000001051.1 ENSMUST00000001051.2 ENSMUST00000001051.3 ENSMUST00000001051.4 ENSMUST00000001051.5 ENSMUST00000001051.6 ENSMUST00000001051.7 ENSMUST00000001051.8 NM_011313 Q545I9 Q545I9_MOUSE S100a6 uc008qdb.1 uc008qdb.2 uc008qdb.3 May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. Nucleus envelope Belongs to the S-100 family. ruffle calcium ion binding tropomyosin binding nucleus nuclear envelope cytoplasm cytosol plasma membrane ion transmembrane transporter activity extrinsic component of cytoplasmic side of plasma membrane ion transmembrane transport protein homodimerization activity S100 protein binding metal ion binding calcium-dependent protein binding perinuclear region of cytoplasm uc008qdb.1 uc008qdb.2 uc008qdb.3 
ENSMUST00000001055.15 Icam2 ENSMUST00000001055.15 intercellular adhesion molecule 2 (from RefSeq NM_010494.2) ENSMUST00000001055.1 ENSMUST00000001055.10 ENSMUST00000001055.11 ENSMUST00000001055.12 ENSMUST00000001055.13 ENSMUST00000001055.14 ENSMUST00000001055.2 ENSMUST00000001055.3 ENSMUST00000001055.4 ENSMUST00000001055.5 ENSMUST00000001055.6 ENSMUST00000001055.7 ENSMUST00000001055.8 ENSMUST00000001055.9 ICAM2_MOUSE Icam-2 NM_010494 P35330 Q9D8Q4 uc007lyx.1 uc007lyx.2 uc007lyx.3 ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Interacts with RDX, EZR and MSN. P35330; P26043: Rdx; NbExp=2; IntAct=EBI-1035485, EBI-647737; Membrane ; Single-pass type I membrane protein Cell projection, microvillus Note=Co-localizes with RDX, EZR and MSN in microvilli. Expressed in endothelial cells and leukocytes. High levels found in lung. Belongs to the immunoglobulin superfamily. ICAM family. Name=Functional Glycomics Gateway - Glycan Binding; Note=ICAM-2; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Itlect_189"; uropod integrin binding protein binding plasma membrane integral component of plasma membrane microvillus cell adhesion membrane integral component of membrane cleavage furrow cell projection cell periphery cell-cell adhesion uc007lyx.1 uc007lyx.2 uc007lyx.3 
ENSMUST00000001059.9 Ern1 ENSMUST00000001059.9 endoplasmic reticulum to nucleus signalling 1 (from RefSeq NM_023913.2) ENSMUST00000001059.1 ENSMUST00000001059.2 ENSMUST00000001059.3 ENSMUST00000001059.4 ENSMUST00000001059.5 ENSMUST00000001059.6 ENSMUST00000001059.7 ENSMUST00000001059.8 ERN1_MOUSE Ern1 Ire1 NM_023913 Q9D340 Q9EQY0 uc007lyy.1 uc007lyy.2 uc007lyy.3 Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11850408, PubMed:25164867). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:25164867). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11850408, PubMed:25164867). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11850408, PubMed:25164867). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi- independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; The kinase domain is activated by trans- autophosphorylation following homodimerization. Kinase activity is required for activation of the endoribonuclease domain (PubMed:25164867). Endoribonuclease activity is specifically inhibited by hydroxy-aryl-aldehydes (HAA) MKC9989, OICR464 and OICR573 (PubMed:25164867). Monomer (By similarity). Homodimer; disulfide-linked; homodimerization takes place in response to endoplasmic reticulum stress and promotes activation of the kinase and endoribonuclease activities (PubMed:25164867). Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges (PubMed:25164867). Interacts (via the luminal region) with DNAJB9/ERdj4; interaction takes place in unstressed cells and promotes recruitment of HSPA5/BiP (By similarity). Interacts (via the luminal region) with HSPA5/BiP; HSPA5/BiP is a negative regulator of the unfolded protein response (UPR) that prevents homodimerization of ERN1/IRE1 and subsequent activation of the protein (By similarity). Interacts with PDIA6, a negative regulator of the UPR; the interaction is direct and disrupts homodimerization (By similarity). Interacts with DAB2IP (via PH domain); the interaction occurs in a endoplasmic reticulum stress-induced dependent manner and is required for subsequent recruitment of TRAF2 to ERN1/IRE1 (PubMed:18281285). Interacts with TAOK3 and TRAF2 (By similarity). Interacts with RNF13 (By similarity). Interacts with LACC1 (By similarity). Interacts (when unphosphorylated) with DDRGK1; interaction is dependent on UFM1 and takes place in response to endoplasmic reticulum stress, regulating ERN1/IRE1-alpha stability (By similarity). Interacts (via N-terminus) with P4HB/PDIA1; the interaction is enhanced by phosphorylation of P4HB by FAM20C in response to endoplasmic reticulum stress and results in attenuation of ERN1 activity (By similarity). Q9EQY0; P25118: Tnfrsf1a; NbExp=2; IntAct=EBI-5480799, EBI-518014; Q9EQY0; P70196: Traf6; NbExp=6; IntAct=EBI-5480799, EBI-448028; Endoplasmic reticulum membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q9EQY0-1; Sequence=Displayed; Name=2 ; IsoId=Q9EQY0-2; Sequence=VSP_050794, VSP_050795; Expressed in liver (at protein level) (PubMed:30118681). Ubiquitously expressed (PubMed:11146108). High levels in thymus, liver and lung. In the brain, preferentially expressed in cortical, hippocampal and olfactory neurons (PubMed:11146108). Autophosphorylated following homodimerization. Autophosphorylation promotes activation of the endoribonuclease domain (PubMed:25164867). In response to ER stress, phosphorylated at Ser-724, Ser-729 and possibly Ser-726; phosphorylation promotes oligomerization and endoribonuclease activity (PubMed:30118681). Dephosphorylated at Ser- 724, Ser-729 and possibly Ser-726 by RPAP2 to abort failed ER-stress adaptation and trigger apoptosis (By similarity). ADP-ribosylated by PARP16 upon ER stress, which increases both kinase and endonuclease activities. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding magnesium ion binding endothelial cell proliferation catalytic activity endonuclease activity endoribonuclease activity ribonuclease activity protein kinase activity protein serine/threonine kinase activity platelet-derived growth factor receptor binding protein binding ATP binding nuclear inner membrane cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane mRNA cleavage mRNA processing protein phosphorylation apoptotic process response to unfolded protein cell cycle arrest activation of JUN kinase activity metabolic process membrane integral component of membrane kinase activity phosphorylation transferase activity hydrolase activity enzyme binding integral component of endoplasmic reticulum membrane Hsp70 protein binding endoplasmic reticulum unfolded protein response positive regulation of RNA splicing cellular response to unfolded protein response to endoplasmic reticulum stress cellular response to vascular endothelial growth factor stimulus peptidyl-serine autophosphorylation IRE1-mediated unfolded protein response identical protein binding protein homodimerization activity ADP binding protein autophosphorylation metal ion binding unfolded protein binding Hsp90 protein binding mRNA splicing, via endonucleolytic cleavage and ligation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to glucose stimulus RNA phosphodiester bond hydrolysis, endonucleolytic mRNA cleavage involved in mRNA processing positive regulation of endoplasmic reticulum unfolded protein response insulin metabolic process positive regulation of vascular smooth muscle cell proliferation peptidyl-serine trans-autophosphorylation AIP1-IRE1 complex IRE1-TRAF2-ASK1 complex IRE1-RACK1-PP2A complex uc007lyy.1 uc007lyy.2 uc007lyy.3 
ENSMUST00000001079.15 Sec24b ENSMUST00000001079.15 SEC24 homolog B, COPII coat complex component, transcript variant 1 (from RefSeq NM_207209.4) ENSMUST00000001079.1 ENSMUST00000001079.10 ENSMUST00000001079.11 ENSMUST00000001079.12 ENSMUST00000001079.13 ENSMUST00000001079.14 ENSMUST00000001079.2 ENSMUST00000001079.3 ENSMUST00000001079.4 ENSMUST00000001079.5 ENSMUST00000001079.6 ENSMUST00000001079.7 ENSMUST00000001079.8 ENSMUST00000001079.9 NM_207209 Q80ZX0 Q80ZX0_MOUSE Sec24b uc008rit.1 uc008rit.2 uc008rit.3 Cytoplasm, cytosol Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the SEC23/SEC24 family. SEC24 subfamily. Golgi membrane neural tube closure auditory receptor cell morphogenesis outflow tract morphogenesis protein binding cytosol intracellular protein transport ER to Golgi vesicle-mediated transport zinc ion binding protein transport cochlear nucleus development COPII vesicle coat ER to Golgi transport vesicle aorta morphogenesis auditory receptor cell stereocilium organization lung morphogenesis lung lobe morphogenesis coronary artery morphogenesis pulmonary artery morphogenesis cardiovascular system development cargo loading into COPII-coated vesicle regulation of establishment of planar polarity involved in neural tube closure regulation of cargo loading into COPII-coated vesicle uc008rit.1 uc008rit.2 uc008rit.3 
ENSMUST00000001080.16 N4bp3 ENSMUST00000001080.16 NEDD4 binding protein 3, transcript variant 1 (from RefSeq NM_145974.4) A2AA64 ENSMUST00000001080.1 ENSMUST00000001080.10 ENSMUST00000001080.11 ENSMUST00000001080.12 ENSMUST00000001080.13 ENSMUST00000001080.14 ENSMUST00000001080.15 ENSMUST00000001080.2 ENSMUST00000001080.3 ENSMUST00000001080.4 ENSMUST00000001080.5 ENSMUST00000001080.6 ENSMUST00000001080.7 ENSMUST00000001080.8 ENSMUST00000001080.9 N4BP3_MOUSE NM_145974 Q3TDC7 Q3URT6 Q7TNR2 Q8C7U1 Q922W0 Q99J06 uc007iue.1 uc007iue.2 uc007iue.3 Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (By similarity). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). Binds NEDD4. Interacts with 14-3-3 proteins. Interacts with MAVS. Cytoplasmic vesicle Cell projection, axon Cell projection, dendrite Note=In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites. Belongs to the N4BP3 family. protein binding multicellular organism development nervous system development biological_process axon dendrite cytoplasmic vesicle cell projection uc007iue.1 uc007iue.2 uc007iue.3 
ENSMUST00000001081.10 Rmnd5b ENSMUST00000001081.10 required for meiotic nuclear division 5 homolog B (from RefSeq NM_025346.1) ENSMUST00000001081.1 ENSMUST00000001081.2 ENSMUST00000001081.3 ENSMUST00000001081.4 ENSMUST00000001081.5 ENSMUST00000001081.6 ENSMUST00000001081.7 ENSMUST00000001081.8 ENSMUST00000001081.9 NM_025346 Q91YQ7 RMD5B_MOUSE uc007iud.1 uc007iud.2 Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Cytoplasm, cytosol nucleus cytoplasm cytosol ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity GID complex proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding ubiquitin-protein transferase activity uc007iud.1 uc007iud.2 
ENSMUST00000001092.15 Zfp276 ENSMUST00000001092.15 zinc finger protein (C2H2 type) 276 (from RefSeq NM_020497.2) ENSMUST00000001092.1 ENSMUST00000001092.10 ENSMUST00000001092.11 ENSMUST00000001092.12 ENSMUST00000001092.13 ENSMUST00000001092.14 ENSMUST00000001092.2 ENSMUST00000001092.3 ENSMUST00000001092.4 ENSMUST00000001092.5 ENSMUST00000001092.6 ENSMUST00000001092.7 ENSMUST00000001092.8 ENSMUST00000001092.9 NM_020497 Q3TQL7 Q3V088 Q80ZN3 Q8C912 Q8CE64 Q9ESV2 ZN276_MOUSE Znf276 uc009nvb.1 uc009nvb.2 uc009nvb.3 uc009nvb.4 May be involved in transcriptional regulation. Nucleus Chromosome, centromere, kinetochore Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CE64-1; Sequence=Displayed; Name=2; IsoId=Q8CE64-2; Sequence=VSP_026106, VSP_026107; Found in all the examined tissues, with highest levels in kidney, liver, lung, and spleen. Expressed at low levels in all stages of embryonic development examined. Sequence=AAG01634.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC31505.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; chromosome, centromeric region kinetochore condensed chromosome kinetochore nucleic acid binding DNA binding nucleus chromosome zinc ion binding metal ion binding uc009nvb.1 uc009nvb.2 uc009nvb.3 uc009nvb.4 
ENSMUST00000001108.11 Add1 ENSMUST00000001108.11 adducin 1, transcript variant 16 (from RefSeq NM_001420955.1) Add1 ENSMUST00000001108.1 ENSMUST00000001108.10 ENSMUST00000001108.2 ENSMUST00000001108.3 ENSMUST00000001108.4 ENSMUST00000001108.5 ENSMUST00000001108.6 ENSMUST00000001108.7 ENSMUST00000001108.8 ENSMUST00000001108.9 F8WGR0 F8WGR0_MOUSE NM_001420955 uc008xcq.1 uc008xcq.2 uc008xcq.3 Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the aldolase class II family. Adducin subfamily. cytoskeleton uc008xcq.1 uc008xcq.2 uc008xcq.3 
ENSMUST00000001112.14 Grk4 ENSMUST00000001112.14 G protein-coupled receptor kinase 4, transcript variant 1 (from RefSeq NM_019497.2) ENSMUST00000001112.1 ENSMUST00000001112.10 ENSMUST00000001112.11 ENSMUST00000001112.12 ENSMUST00000001112.13 ENSMUST00000001112.2 ENSMUST00000001112.3 ENSMUST00000001112.4 ENSMUST00000001112.5 ENSMUST00000001112.6 ENSMUST00000001112.7 ENSMUST00000001112.8 ENSMUST00000001112.9 GRK4_MOUSE Gprk2l NM_019497 O70291 Q3V151 uc008xcz.1 uc008xcz.2 Specifically phosphorylates the activated forms of G protein- coupled receptors. Reaction=[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+); Xref=Rhea:RHEA:12008, Rhea:RHEA- COMP:11260, Rhea:RHEA-COMP:11261, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.16; Inhibited by heparin. Interacts with DRD3. Cytoplasm. Cytoplasm, cell cortex Palmitoylated. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. nucleotide binding desensitization of G-protein coupled receptor protein signaling pathway G-protein coupled receptor internalization protein kinase activity protein serine/threonine kinase activity G-protein coupled receptor kinase activity ATP binding cytoplasm cytosol cell cortex protein phosphorylation signal transduction kinase activity phosphorylation transferase activity dendrite receptor internalization neuronal cell body rhodopsin kinase activity uc008xcz.1 uc008xcz.2 
ENSMUST00000001122.6 Slc13a2 ENSMUST00000001122.6 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 (from RefSeq NM_022411.4) ENSMUST00000001122.1 ENSMUST00000001122.2 ENSMUST00000001122.3 ENSMUST00000001122.4 ENSMUST00000001122.5 NM_022411 Nadc1 Q9ES88 S13A2_MOUSE Sdct1 uc007kjf.1 uc007kjf.2 uc007kjf.3 Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:10966927) (By similarity). Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (PubMed:10966927). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (By similarity). Has a critical role in renal dicarboxylate transport (PubMed:17410095). Reaction=3 Na(+)(out) + succinate(out) = 3 Na(+)(in) + succinate(in); Xref=Rhea:RHEA:71919, ChEBI:CHEBI:29101, ChEBI:CHEBI:30031; Evidence=; Reaction=fumarate(out) + 3 Na(+)(out) = fumarate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:71931, ChEBI:CHEBI:29101, ChEBI:CHEBI:29806; Evidence=; Reaction=2-oxoglutarate(out) + 3 Na(+)(out) = 2-oxoglutarate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:71939, ChEBI:CHEBI:16810, ChEBI:CHEBI:29101; Evidence=; Li(+) decreases succinate transport in the presence of Na(+), by competing at one of the three cation binding sites. Kinetic parameters: KM=0.6 mM for citrate ; KM=0.35 mM for succinate ; Apical cell membrane ; Multi-pass membrane protein Highly expressed in kidney and small intestine. Not detectable in brain, heart, stomach and skeletal muscle. Deficient mice display increased urinary excretion of citrate, alpha-ketoglutarate, fumarate, and malate and a modest increase in succinate. Despite the increased excretion, there is no significant change in plasma citrate concentration. No other phenotypic change is identified in these mice. Transporter deficiency do not affect renal function under normal physiological conditions, nor to response to renal injury. Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. ion transport sodium ion transport symporter activity membrane integral component of membrane transmembrane transporter activity transmembrane transport uc007kjf.1 uc007kjf.2 uc007kjf.3 
ENSMUST00000001126.4 Slc46a1 ENSMUST00000001126.4 solute carrier family 46, member 1 (from RefSeq NM_026740.2) D11Ertd18e ENSMUST00000001126.1 ENSMUST00000001126.2 ENSMUST00000001126.3 Hcp1 NM_026740 PCFT_MOUSE Pcft Q571I8 Q5SYG0 Q6PEM8 Q8R1H7 Q9D1P1 Slc46a1 uc007kjg.1 uc007kjg.2 uc007kjg.3 uc007kjg.4 Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:17962486). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:17962486). Functions at acidic pH via alternate outward- and inward-open conformation states (By similarity). Protonation of residues in the outward open state primes the protein for transport (By similarity). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward- open state and release of protons and folate (By similarity). Also able to transport antifolate drugs, such as methotrexate and pemetrexed (PubMed:17962486). Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (By similarity). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (PubMed:16143108). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (PubMed:22058337). Hence, participates in the trafficking of heme and increases intracellular iron content (By similarity). Reaction=folate(in) + H(+)(in) = folate(out) + H(+)(out); Xref=Rhea:RHEA:70159, ChEBI:CHEBI:15378, ChEBI:CHEBI:62501; Evidence=; Reaction=(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)- 5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out); Xref=Rhea:RHEA:70167, ChEBI:CHEBI:15378, ChEBI:CHEBI:18608; Evidence=; Reaction=H(+)(in) + methotrexate(in) = H(+)(out) + methotrexate(out); Xref=Rhea:RHEA:70163, ChEBI:CHEBI:15378, ChEBI:CHEBI:50681; Evidence=; Reaction=H(+)(in) + pemetrexed(in) = H(+)(out) + pemetrexed(out); Xref=Rhea:RHEA:70171, ChEBI:CHEBI:15378, ChEBI:CHEBI:63724; Evidence=; Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Cytoplasm Note=Shifts from the apical membrane of intestinal cells iron-deficient cells to the cytoplasm in response to increased in iron stores (PubMed:16143108). Localizes to the basolateral membrane of choroid plexus (PubMed:19074442). Highly expressed in duodenum, especially in duodenal mucosa, the main site of intestinal heme absorption (PubMed:16143108). Expressed in the retina and retinal pigment epithelium (PubMed:17962486, PubMed:22058337). Weakly expressed in the kidney (PubMed:16143108). Not expressed in duodenum before weaning or in placenta (PubMed:16143108). Weakly or not expressed in brain, heart, lung, skeletal muscle, testis and neonatal liver (PubMed:16143108). Up-regulated in response to hypoxia, it is however unclear whether such up-regulation is direct or not (PubMed:16143108). Not induced in the duodenum of iron-deficient mice (PubMed:16143108). Deletion mutant mice develop severe macrocytic normochromic anemia and ineffective erythropoiesis (PubMed:21346251). More than 90% of mice die by 10 to 12 weeks of age (PubMed:21346251). Belongs to the major facilitator superfamily. SLC46A family. Sequence=BAD90126.1; Type=Erroneous initiation; Evidence=; Sequence=CAI25543.1; Type=Erroneous gene model prediction; Evidence=; folic acid binding cytoplasm plasma membrane integral component of plasma membrane folic acid transporter activity hydrogen ion transmembrane transporter activity heme transporter activity methotrexate transporter activity folic acid transport heme transport membrane integral component of membrane apical plasma membrane transmembrane transporter activity brush border membrane methotrexate transport transmembrane transport hydrogen ion transmembrane transport folic acid import into cell uc007kjg.1 uc007kjg.2 uc007kjg.3 uc007kjg.4 
ENSMUST00000001127.11 Poldip2 ENSMUST00000001127.11 polymerase (DNA-directed), delta interacting protein 2, transcript variant 3 (from RefSeq NR_184830.1) ENSMUST00000001127.1 ENSMUST00000001127.10 ENSMUST00000001127.2 ENSMUST00000001127.3 ENSMUST00000001127.4 ENSMUST00000001127.5 ENSMUST00000001127.6 ENSMUST00000001127.7 ENSMUST00000001127.8 ENSMUST00000001127.9 NR_184830 PDIP2_MOUSE Poldip2 Q91VA6 uc007kjo.1 uc007kjo.2 uc007kjo.3 Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites. May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1). Interacts with PCNA and POLD2. Interacts with SSBP1. Interacts with PRIMPOL; leading to enhance DNA polymerase activity of PRIMPOL. Interacts with POLH. Interacts with POLD1; leading to stimulate DNA polymerase activity of POLD1. Mitochondrion matrix Nucleus Note=Mainly localizes to the mitochondrial matrix; a small fraction localizes in the nucleus. DNA binding nucleus mitochondrion negative regulation of macroautophagy protein binding, bridging mitochondrial nucleoid positive regulation of mitotic cell cycle mitochondrion morphogenesis uc007kjo.1 uc007kjo.2 uc007kjo.3 
ENSMUST00000001130.8 Sebox ENSMUST00000001130.8 SEBOX homeobox (from RefSeq NM_008759.3) ENSMUST00000001130.1 ENSMUST00000001130.2 ENSMUST00000001130.3 ENSMUST00000001130.4 ENSMUST00000001130.5 ENSMUST00000001130.6 ENSMUST00000001130.7 NM_008759 Og9x P70368 SEBOX_MOUSE uc007kjm.1 uc007kjm.2 uc007kjm.3 uc007kjm.4 Probable transcription factor involved in the control of specification of mesoderm and endoderm. Nucleus Expressed in brain, skin, ovary and liver. Also expressed in maturing oocytes, eggs, zygotes and 2-cell embryos, but not 4-cell embryos. Expressed in embryos from day 7. Expression is low in 12 day embryos and higher in 18 and 19 day embryos. Belongs to the paired homeobox family. molecular_function DNA binding cellular_component nucleus multicellular organism development embryo development ending in birth or egg hatching cell differentiation oogenesis uc007kjm.1 uc007kjm.2 uc007kjm.3 uc007kjm.4 
ENSMUST00000001147.5 Col6a1 ENSMUST00000001147.5 collagen, type VI, alpha 1 (from RefSeq NM_009933.5) CO6A1_MOUSE ENSMUST00000001147.1 ENSMUST00000001147.2 ENSMUST00000001147.3 ENSMUST00000001147.4 NM_009933 Q04857 uc007fux.1 uc007fux.2 uc007fux.3 Collagen VI acts as a cell-binding protein. Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha- 6(VI). Secreted, extracellular space, extracellular matrix Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Belongs to the type VI collagen family. growth plate cartilage chondrocyte morphogenesis collagen binding extracellular region collagen trimer extracellular space cell adhesion extracellular matrix structural constituent conferring tensile strength extracellular matrix macromolecular complex endodermal cell differentiation sarcolemma platelet-derived growth factor binding cellular response to amino acid stimulus uc007fux.1 uc007fux.2 uc007fux.3 
ENSMUST00000001148.11 Pcbp3 ENSMUST00000001148.11 poly(rC) binding protein 3, transcript variant 1 (from RefSeq NM_021568.2) ENSMUST00000001148.1 ENSMUST00000001148.10 ENSMUST00000001148.2 ENSMUST00000001148.3 ENSMUST00000001148.4 ENSMUST00000001148.5 ENSMUST00000001148.6 ENSMUST00000001148.7 ENSMUST00000001148.8 ENSMUST00000001148.9 NM_021568 P57722 PCBP3_MOUSE Q8BSB0 Q8C544 uc007fuz.1 uc007fuz.2 uc007fuz.3 uc007fuz.4 Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P57722-1; Sequence=Displayed; Name=2; IsoId=P57722-2; Sequence=VSP_010015; Widely expressed, with highest levels in testis and fat tissues and lowest in heart. [Isoform 2]: May be due to a competing acceptor splice site. Sequence=AAG09238.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding double-stranded DNA binding RNA binding cytoplasm C-rich single-stranded DNA binding uc007fuz.1 uc007fuz.2 uc007fuz.3 uc007fuz.4 
ENSMUST00000001155.11 Araf ENSMUST00000001155.11 Araf proto-oncogene, serine/threonine kinase, transcript variant 1 (from RefSeq NM_009703.2) A-raf ARAF_MOUSE Araf1 B1AUN9 ENSMUST00000001155.1 ENSMUST00000001155.10 ENSMUST00000001155.2 ENSMUST00000001155.3 ENSMUST00000001155.4 ENSMUST00000001155.5 ENSMUST00000001155.6 ENSMUST00000001155.7 ENSMUST00000001155.8 ENSMUST00000001155.9 NM_009703 P04627 Q99J44 Q9CTT5 Q9D6R6 Q9DBU7 uc009stu.1 uc009stu.2 uc009stu.3 uc009stu.4 Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). Phosphorylates PFKFB2 (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Interacts with TH1L/NELFD. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. MAPK cascade nucleotide binding activation of MAPKK activity protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity protein binding ATP binding mitochondrion cytosol protein phosphorylation signal transduction kinase activity phosphorylation transferase activity immortalization of host cell regulation of TOR signaling regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of peptidyl-serine phosphorylation intracellular signal transduction negative regulation of apoptotic process metal ion binding uc009stu.1 uc009stu.2 uc009stu.3 uc009stu.4 
ENSMUST00000001156.8 Cfp ENSMUST00000001156.8 complement factor properdin (from RefSeq NM_008823.4) ENSMUST00000001156.1 ENSMUST00000001156.2 ENSMUST00000001156.3 ENSMUST00000001156.4 ENSMUST00000001156.5 ENSMUST00000001156.6 ENSMUST00000001156.7 NM_008823 P11680 PROP_MOUSE Pfc Q3TB98 Q3U779 uc009sub.1 uc009sub.2 uc009sub.3 A positive regulator of the alternate pathway of complement (PubMed:28264884). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (By similarity). Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (By similarity). In plasma, properdin exists as dimers, trimers or tetramers in the relative proportions of 26:54:20 (By similarity). Interacts with the pro-C3-convertase enzyme complex (C3b-Bb) comprised of Complement C3 beta chain (C3b) and the Complement factor B Bb fragment (Bb), where it binds (via its TSP type-1 5 domain) with C3b and Bb (By similarity). This interaction stabilizes the complex and allows it to become the active C3-convertase enzyme complex (C3b-Bb-FP) (By similarity). Interacts with C3b (PubMed:28264884). Interacts with CFB (By similarity). Secreted TSP type-1 domain 0 binds to TSP type-1 domain 4, and TSP type- 1 domain 1 binds to TSP type-1 domain 6 (By similarity). These interactions mediate multimerization (By similarity). immune system process extracellular region extracellular space complement activation, alternative pathway secretory granule innate immune response uc009sub.1 uc009sub.2 uc009sub.3 
ENSMUST00000001166.14 Cnnm3 ENSMUST00000001166.14 cyclin M3, transcript variant 1 (from RefSeq NM_053186.3) A3KML7 Acdp3 CNNM3_MOUSE ENSMUST00000001166.1 ENSMUST00000001166.10 ENSMUST00000001166.11 ENSMUST00000001166.12 ENSMUST00000001166.13 ENSMUST00000001166.2 ENSMUST00000001166.3 ENSMUST00000001166.4 ENSMUST00000001166.5 ENSMUST00000001166.6 ENSMUST00000001166.7 ENSMUST00000001166.8 ENSMUST00000001166.9 NM_053186 Q32NY4 Q3UFE5 Q7TSZ4 Q8C342 Q9JIM6 uc007aqj.1 uc007aqj.2 uc007aqj.3 Probable metal transporter. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q32NY4-1; Sequence=Displayed; Name=2; IsoId=Q32NY4-2; Sequence=VSP_027084; Widely expressed with highest levels in brain, kidney, liver, lung and heart. Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo. Belongs to the ACDP family. Sequence=AAF86376.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI08418.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; plasma membrane ion transport membrane integral component of membrane transmembrane transporter activity transmembrane transport uc007aqj.1 uc007aqj.2 uc007aqj.3 
ENSMUST00000001172.12 Ankrd39 ENSMUST00000001172.12 ankyrin repeat domain 39, transcript variant 1 (from RefSeq NM_026241.4) ANR39_MOUSE ENSMUST00000001172.1 ENSMUST00000001172.10 ENSMUST00000001172.11 ENSMUST00000001172.2 ENSMUST00000001172.3 ENSMUST00000001172.4 ENSMUST00000001172.5 ENSMUST00000001172.6 ENSMUST00000001172.7 ENSMUST00000001172.8 ENSMUST00000001172.9 NM_026241 Q9D2X0 uc007aqo.1 uc007aqo.2 uc007aqo.3 uc007aqo.4 Belongs to the ANKRD39 family. molecular_function cellular_component biological_process uc007aqo.1 uc007aqo.2 uc007aqo.3 uc007aqo.4 
ENSMUST00000001181.13 Col6a2 ENSMUST00000001181.13 collagen, type VI, alpha 2, transcript variant 1 (from RefSeq NM_146007.2) CO6A2_MOUSE ENSMUST00000001181.1 ENSMUST00000001181.10 ENSMUST00000001181.11 ENSMUST00000001181.12 ENSMUST00000001181.2 ENSMUST00000001181.3 ENSMUST00000001181.4 ENSMUST00000001181.5 ENSMUST00000001181.6 ENSMUST00000001181.7 ENSMUST00000001181.8 ENSMUST00000001181.9 NM_146007 Q02788 Q05505 Q8C972 Q8K229 uc007fuu.1 uc007fuu.2 uc007fuu.3 uc007fuu.4 Collagen VI acts as a cell-binding protein. Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha- 6(VI). Interacts with CSPG4 (By similarity). Secreted, extracellular space, extracellular matrix Membrane ; Peripheral membrane protein Note=Recruited on membranes by CSPG4. Highly expressed in adipose tissue, lung, adrenal glands and ovary. Lower levels in testis, tongue, skin, kidney, heart, intestine and spleen. No expression in skeletal muscle or liver. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Belongs to the type VI collagen family. Sequence=BAC31374.2; Type=Erroneous initiation; Evidence=; Sequence=CAA46541.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAA46541.1; Type=Frameshift; Evidence=; growth plate cartilage chondrocyte morphogenesis collagen binding extracellular region collagen trimer extracellular space cell adhesion response to glucose membrane extracellular matrix structural constituent conferring tensile strength extracellular matrix macromolecular complex sarcolemma uc007fuu.1 uc007fuu.2 uc007fuu.3 uc007fuu.4 
ENSMUST00000001183.8 Ftcd ENSMUST00000001183.8 formiminotransferase cyclodeaminase (from RefSeq NM_080845.2) ENSMUST00000001183.1 ENSMUST00000001183.2 ENSMUST00000001183.3 ENSMUST00000001183.4 ENSMUST00000001183.5 ENSMUST00000001183.6 ENSMUST00000001183.7 FTCD_MOUSE NM_080845 Q91XD4 uc007fut.1 uc007fut.2 uc007fut.3 uc007fut.4 Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity). Binds and promotes bundling of vimentin filaments originating from the Golgi. Reaction=5-formimidoyltetrahydrofolate + L-glutamate = (6S)-5,6,7,8- tetrahydrofolate + N-formimidoyl-L-glutamate; Xref=Rhea:RHEA:15097, ChEBI:CHEBI:29985, ChEBI:CHEBI:57453, ChEBI:CHEBI:57456, ChEBI:CHEBI:58928; EC=2.1.2.5; Reaction=(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate = (6S)- 5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate; Xref=Rhea:RHEA:23240, ChEBI:CHEBI:15378, ChEBI:CHEBI:17684, ChEBI:CHEBI:29985, ChEBI:CHEBI:57453, ChEBI:CHEBI:57457; EC=2.1.2.5; Reaction=5-formimidoyltetrahydrofolate + 2 H(+) = (6R)-5,10- methenyltetrahydrofolate + NH4(+); Xref=Rhea:RHEA:22736, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57455, ChEBI:CHEBI:57456; EC=4.3.1.4; Amino-acid degradation; L-histidine degradation into L- glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1. One-carbon metabolism; tetrahydrofolate interconversion. Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring- shaped structure (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Golgi apparatus Note=More abundantly located around the mother centriole. In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family. In the N-terminal section; belongs to the formiminotransferase family. Golgi membrane catalytic activity folic acid binding cytoplasm endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus centriole cytosol cytoskeleton plasma membrane histidine metabolic process histidine catabolic process cytoskeleton organization microtubule binding metabolic process transferase activity lyase activity histidine catabolic process to glutamate and formamide histidine catabolic process to glutamate and formate formimidoyltransferase activity glutamate formimidoyltransferase activity formimidoyltetrahydrofolate cyclodeaminase activity smooth endoplasmic reticulum membrane tetrahydrofolate interconversion cellular metabolic process uc007fut.1 uc007fut.2 uc007fut.3 uc007fut.4 
ENSMUST00000001184.10 Mxd1 ENSMUST00000001184.10 MAX dimerization protein 1, transcript variant 1 (from RefSeq NM_010751.4) ENSMUST00000001184.1 ENSMUST00000001184.2 ENSMUST00000001184.3 ENSMUST00000001184.4 ENSMUST00000001184.5 ENSMUST00000001184.6 ENSMUST00000001184.7 ENSMUST00000001184.8 ENSMUST00000001184.9 Mxd1 NM_010751 Q8K1Z8 Q8K1Z8_MOUSE uc009csh.1 uc009csh.2 uc009csh.3 uc009csh.4 uc009csh.5 Nucleus negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleoplasm mitochondrion cytosol protein dimerization activity uc009csh.1 uc009csh.2 uc009csh.3 uc009csh.4 uc009csh.5 
ENSMUST00000001185.14 Gmcl1 ENSMUST00000001185.14 germ cell-less, spermatogenesis associated 1 (from RefSeq NM_011818.3) ENSMUST00000001185.1 ENSMUST00000001185.10 ENSMUST00000001185.11 ENSMUST00000001185.12 ENSMUST00000001185.13 ENSMUST00000001185.2 ENSMUST00000001185.3 ENSMUST00000001185.4 ENSMUST00000001185.5 ENSMUST00000001185.6 ENSMUST00000001185.7 ENSMUST00000001185.8 ENSMUST00000001185.9 GMCL1_MOUSE Gcl Gcl1 NM_011818 Q920G9 Q9DBW5 Q9QUP6 uc009csl.1 uc009csl.2 uc009csl.3 uc009csl.4 Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport. Interacts with TMPO-Beta, TSG101 and TFDP2. Interacts with EMD (By similarity). Nucleus matrix. Ubiquitously expressed at low levels throughout development and in adult tissues. Highest levels in pachytene and diplotene stage spermatocytes and primordial germ cells of the male and the female. protein binding nucleus nuclear envelope regulation of transcription, DNA-templated multicellular organism development spermatogenesis nuclear matrix cell differentiation uc009csl.1 uc009csl.2 uc009csl.3 uc009csl.4 
ENSMUST00000001186.11 Snrnp27 ENSMUST00000001186.11 small nuclear ribonucleoprotein 27 (U4/U6.U5) (from RefSeq NM_025665.2) ENSMUST00000001186.1 ENSMUST00000001186.10 ENSMUST00000001186.2 ENSMUST00000001186.3 ENSMUST00000001186.4 ENSMUST00000001186.5 ENSMUST00000001186.6 ENSMUST00000001186.7 ENSMUST00000001186.8 ENSMUST00000001186.9 NM_025665 Q8BRA8 Q8K194 Q9CSV0 SNR27_MOUSE uc009csj.1 uc009csj.2 uc009csj.3 May play a role in mRNA splicing. Part of a tri-snRNP complex. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K194-1; Sequence=Displayed; Name=2; IsoId=Q8K194-2; Sequence=VSP_017317; Belongs to the SNUT3 family. molecular_function nucleus mRNA processing biological_process RNA splicing uc009csj.1 uc009csj.2 uc009csj.3 
ENSMUST00000001187.15 Anxa4 ENSMUST00000001187.15 annexin A4, transcript variant 2 (from RefSeq NM_013471.3) ANXA4_MOUSE Anx4 ENSMUST00000001187.1 ENSMUST00000001187.10 ENSMUST00000001187.11 ENSMUST00000001187.12 ENSMUST00000001187.13 ENSMUST00000001187.14 ENSMUST00000001187.2 ENSMUST00000001187.3 ENSMUST00000001187.4 ENSMUST00000001187.5 ENSMUST00000001187.6 ENSMUST00000001187.7 ENSMUST00000001187.8 ENSMUST00000001187.9 NM_013471 P97429 Q3UCL0 uc009csn.1 uc009csn.2 uc009csn.3 uc009csn.4 Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Zymogen granule membrane ; Peripheral membrane protein A pair of annexin repeats may form one binding site for calcium and phospholipid. Seems to bind one calcium ion with high affinity. Belongs to the annexin family. kidney development calcium ion binding calcium-dependent phospholipid binding nucleus cytoplasm cytosol plasma membrane regulation of transcription from RNA polymerase II promoter Notch signaling pathway heparin binding cell surface vesicle membrane apical plasma membrane epithelial cell differentiation nuclear membrane negative regulation of NF-kappaB transcription factor activity chondroitin sulfate binding identical protein binding calcium-dependent protein binding perinuclear region of cytoplasm NF-kappaB binding negative regulation of interleukin-8 secretion uc009csn.1 uc009csn.2 uc009csn.3 uc009csn.4 
ENSMUST00000001202.15 Ocrl ENSMUST00000001202.15 OCRL, inositol polyphosphate-5-phosphatase (from RefSeq NM_177215.3) ENSMUST00000001202.1 ENSMUST00000001202.10 ENSMUST00000001202.11 ENSMUST00000001202.12 ENSMUST00000001202.13 ENSMUST00000001202.14 ENSMUST00000001202.2 ENSMUST00000001202.3 ENSMUST00000001202.4 ENSMUST00000001202.5 ENSMUST00000001202.6 ENSMUST00000001202.7 ENSMUST00000001202.8 ENSMUST00000001202.9 NM_177215 OCRL_MOUSE Ocrl Ocrl1 Q6NVF0 Q8BXC9 uc009tbr.1 uc009tbr.2 uc009tbr.3 uc009tbr.4 Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5- bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol 4-phosphate) + phosphate; Xref=Rhea:RHEA:22764, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456; EC=3.1.3.36; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22765; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + phosphate; Xref=Rhea:RHEA:25528, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57658, ChEBI:CHEBI:57836; EC=3.1.3.86; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25529; Evidence=; Reaction=1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo- inositol 1,3,4-trisphosphate + phosphate; Xref=Rhea:RHEA:11392, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57895, ChEBI:CHEBI:58414; EC=3.1.3.56; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11393; Evidence=; Reaction=1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate; Xref=Rhea:RHEA:19797, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58282, ChEBI:CHEBI:203600; EC=3.1.3.56; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19798; Evidence=; Interacts with APPL1, PHETA1/SES1 and PHETA2/SES2; APPL1- binding and PHETA1-binding are mutually exclusive (By similarity). Interacts with clathrin heavy chain. Interacts with several Rab GTPases, at least RAB1B, RAB5A, RAB6A, RAB8A and RAB31; these interactions may play a dual role in targeting OCRL to the specific membranes and stimulating the phosphatase activitye (PubMed:25869668). Interaction with RAB8A modulates OCRL recruitment to cilia. Interacts with RAB31 (By similarity). Interacts with INPP5F (PubMed:25869668). Cytoplasmic vesicle, phagosome membrane Early endosome membrane Membrane, clathrin-coated pit Cell projection, cilium, photoreceptor outer segment Cell projection, cilium Cytoplasmic vesicle Endosome Golgi apparatus, trans-Golgi network Note=Also found on macropinosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NVF0-1; Sequence=Displayed; Name=2; IsoId=Q6NVF0-2; Sequence=VSP_045749, VSP_045750; The ASH (ASPM-SPD2-Hydin) and RhoGAP (Rho GTPase activating) domains form a single folding module. The ASH domain has an immunoglobulin-like fold, the Rho-GAP domain lacks the catalytic arginine and is catalytically inactive. The ASH-RhoGAP module regulates the majority of the protein-protein interactions currently described. The ASH domain mediates association with membrane-targeting Rab GTPases. The Rho-GAP domain interacts with the endocytic adapter APPL1, which is then displaced by PHETA1 and PHETA2 as endosomes mature (By similarity). Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. in utero embryonic development photoreceptor outer segment phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity GTPase activator activity nucleus cytoplasm endosome early endosome Golgi apparatus trans-Golgi network plasma membrane clathrin-coated pit cilium signal transduction membrane hydrolase activity cell projection organization clathrin-coated vesicle phagocytic vesicle membrane cytoplasmic vesicle early endosome membrane cell projection regulation of GTPase activity positive regulation of GTPase activity inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation Rac GTPase binding inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity inositol phosphate phosphatase activity cilium assembly uc009tbr.1 uc009tbr.2 uc009tbr.3 uc009tbr.4 
ENSMUST00000001240.12 Agpat3 ENSMUST00000001240.12 1-acylglycerol-3-phosphate O-acyltransferase 3, transcript variant 1 (from RefSeq NM_053014.4) Agpat3 C4B4E7 ENSMUST00000001240.1 ENSMUST00000001240.10 ENSMUST00000001240.11 ENSMUST00000001240.2 ENSMUST00000001240.3 ENSMUST00000001240.4 ENSMUST00000001240.5 ENSMUST00000001240.6 ENSMUST00000001240.7 ENSMUST00000001240.8 ENSMUST00000001240.9 Lpaat3 NM_053014 PLCC_MOUSE Q7TT39 Q8BST2 Q9D517 uc007fxr.1 uc007fxr.2 uc007fxr.3 Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:15367102). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (By similarity). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (By similarity). Has a preference for arachidonoyl-CoA as a donor (PubMed:19114731). Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (PubMed:19114731). Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19710; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37175, ChEBI:CHEBI:57287, ChEBI:CHEBI:74309, ChEBI:CHEBI:74544, ChEBI:CHEBI:74578; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37176; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37155, ChEBI:CHEBI:57287, ChEBI:CHEBI:74307, ChEBI:CHEBI:74544, ChEBI:CHEBI:74558; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37156; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37147, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:74544, ChEBI:CHEBI:74552; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37148; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37595, ChEBI:CHEBI:57287, ChEBI:CHEBI:74544, ChEBI:CHEBI:75104, ChEBI:CHEBI:75105; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37596; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn- glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37443, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74544, ChEBI:CHEBI:74928; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37444; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74544, ChEBI:CHEBI:74546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37132; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero- 3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn- glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37159, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74544, ChEBI:CHEBI:74563; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37160; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn- glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)- icosatetraenoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37395, ChEBI:CHEBI:28610, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74671; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37396; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn- glycero-3-phospho-(1D-myo-inositol) = 1-(9Z-octadecenoyl)-2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA; Xref=Rhea:RHEA:42216, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:78762, ChEBI:CHEBI:78765; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42217; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn- glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37379, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74617, ChEBI:CHEBI:74897; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37380; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:33187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57518, ChEBI:CHEBI:64839; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33188; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn- glycero-3-phosphate = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:35915, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:57518, ChEBI:CHEBI:72864; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35916; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn- glycero-3-phosphate = 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:42220, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74554, ChEBI:CHEBI:78768; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42221; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37163, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74560, ChEBI:CHEBI:74565; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37164; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn- glycero-3-phosphate = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:42588, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74565, ChEBI:CHEBI:77091; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42589; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:42592, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:64839, ChEBI:CHEBI:74544; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42593; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)- sn-glycero-3-phosphate = 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:45404, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:78402, ChEBI:CHEBI:85231; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45405; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3- phospho-(1D-myo-inositol) = a 1-acyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:37015, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:64771, ChEBI:CHEBI:75243; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37016; Evidence=; In males, activity increases in an age-dependent fashion, maybe derived from the induction by sex-hormones. Kinetic parameters: KM=15.9 uM for arachidonoyl-CoA ; KM=26.3 uM for palmitoyl-LPA ; Vmax=50.4 nmol/min/mg enzyme toward arachidonoyl-CoA ; Vmax=21.8 nmol/min/mg enzyme toward palmitoyl-LPA ; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 2/3. Endoplasmic reticulum membrane ; Multi-pass membrane protein Nucleus envelope Widely expressed. Mainly expressed in testis, kidney and liver (at protein level). Up-regulated in the heart by clofibrate, a PPAR-alpha agonist. The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. Sequence=BAC27043.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; 1-acylglycerol-3-phosphate O-acyltransferase activity nucleus nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phospholipid biosynthetic process membrane integral component of membrane CDP-diacylglycerol biosynthetic process transferase activity transferase activity, transferring acyl groups lysophosphatidic acid acyltransferase activity uc007fxr.1 uc007fxr.2 uc007fxr.3 
ENSMUST00000001242.9 Gatd3a ENSMUST00000001242.9 glutamine amidotransferase like class 1 domain containing 3A, transcript variant 1 (from RefSeq NM_138601.3) D10Jhu81e ENSMUST00000001242.1 ENSMUST00000001242.2 ENSMUST00000001242.3 ENSMUST00000001242.4 ENSMUST00000001242.5 ENSMUST00000001242.6 ENSMUST00000001242.7 ENSMUST00000001242.8 GAL3A_MOUSE Gatd3 Gatd3a NM_138601 Q9D172 uc007fxj.1 uc007fxj.2 uc007fxj.3 Mitochondrion Belongs to the GATD3 family. molecular_function mitochondrion biological_process uc007fxj.1 uc007fxj.2 uc007fxj.3 
ENSMUST00000001247.12 Rnf32 ENSMUST00000001247.12 ring finger protein 32, transcript variant 1 (from RefSeq NM_001289757.1) ENSMUST00000001247.1 ENSMUST00000001247.10 ENSMUST00000001247.11 ENSMUST00000001247.2 ENSMUST00000001247.3 ENSMUST00000001247.4 ENSMUST00000001247.5 ENSMUST00000001247.6 ENSMUST00000001247.7 ENSMUST00000001247.8 ENSMUST00000001247.9 Lmbr2 NM_001289757 Q9D9X0 Q9DAJ3 Q9JIT1 RNF32_MOUSE uc008wue.1 uc008wue.2 uc008wue.3 uc008wue.4 May play a role in sperm formation. Cytoplasm No coding region alterations in either Hemimelic extra- toes (Hx) or Hammertoe (Hm) mutant mice was detected. molecular_function cytoplasm endosome biological_process aggresome metal ion binding uc008wue.1 uc008wue.2 uc008wue.3 uc008wue.4 
ENSMUST00000001253.8 Slc26a4 ENSMUST00000001253.8 solute carrier family 26, member 4 (from RefSeq NM_011867.4) ENSMUST00000001253.1 ENSMUST00000001253.2 ENSMUST00000001253.3 ENSMUST00000001253.4 ENSMUST00000001253.5 ENSMUST00000001253.6 ENSMUST00000001253.7 NM_011867 Pds Q9R155 S26A4_MOUSE uc007nho.1 uc007nho.2 uc007nho.3 Sodium-independent transporter of chloride and iodide (By similarity). Mediates electroneutral iodide-chloride, iodide- bicarbonate and chloride-bicarbonate exchange with 1:1 stoichiometry (PubMed:11274445, PubMed:18565999). Mediates elctroneutral chloride- formate exchange (By similarity). Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29825; Evidence=; Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324, ChEBI:CHEBI:16382; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66325; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:66326; Evidence=; Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) + hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996; Evidence= Reaction=hydrogencarbonate(out) + iodide(in) = hydrogencarbonate(in) + iodide(out); Xref=Rhea:RHEA:72375, ChEBI:CHEBI:16382, ChEBI:CHEBI:17544; Evidence=; Reaction=chloride(out) + iodide(in) = chloride(in) + iodide(out); Xref=Rhea:RHEA:72379, ChEBI:CHEBI:16382, ChEBI:CHEBI:17996; Evidence=; Reaction=chloride(out) + formate(in) = chloride(in) + formate(out); Xref=Rhea:RHEA:72267, ChEBI:CHEBI:15740, ChEBI:CHEBI:17996; Evidence=; Interacts with IQGAP1 (PubMed:35601831). This interaction enhances the chloride-bicarbonate exchange activity of SLC26A4 (By similarity). Apical cell membrane ulti-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney. Highly expressed in the kidney (at protein level) (PubMed:11274445, PubMed:35601831). Throughout the endolymphatic duct and sac, in distinct areas of the utricle and saccule, and in the external sulcus region within the cochlea (PubMed:10449762). Expressed in the parotid gland (PubMed:18565999). Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. plasma membrane integral component of plasma membrane regulation of pH secondary active sulfate transmembrane transporter activity sulfate transport anion transmembrane transporter activity animal organ morphogenesis bicarbonate transmembrane transporter activity chloride transmembrane transporter activity iodide transmembrane transporter activity sulfate transmembrane transporter activity anion:anion antiporter activity inorganic anion transport bicarbonate transport iodide transport membrane integral component of membrane apical plasma membrane oxalate transmembrane transporter activity oxalate transport brush border membrane regulation of protein localization transmembrane transport extracellular exosome anion transmembrane transport sulfate transmembrane transport chloride transmembrane transport uc007nho.1 uc007nho.2 uc007nho.3 
ENSMUST00000001254.6 Slc26a3 ENSMUST00000001254.6 solute carrier family 26, member 3 (from RefSeq NM_021353.3) B2RTD9 Dra ENSMUST00000001254.1 ENSMUST00000001254.2 ENSMUST00000001254.3 ENSMUST00000001254.4 ENSMUST00000001254.5 NM_021353 Q9WVC8 S26A3_MOUSE uc007nhj.1 uc007nhj.2 uc007nhj.3 uc007nhj.4 uc007nhj.5 This gene encodes a member of the solute carrier/sulfate transporter family. The encoded protein is predominantly expressed in the intestine where it is essential for chloride absorption. Disruption of this gene results in chloride-rich diarrhea and compensatory up-regulation of ion-absorbing transporters. [provided by RefSeq, Dec 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF136751.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:10428871). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:21976599). Reaction=2 chloride(out) + hydrogencarbonate(in) = 2 chloride(in) + hydrogencarbonate(out); Xref=Rhea:RHEA:72203, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996; Evidence= Interacts with PDZK1 (By similarity). Interacts with CFTR, SLC26A6 and NHERF1 (PubMed:21976599). Interacts (via PDZ-binding motif) with NHERF4 (via the third PDZ domain) (PubMed:22627094). This interaction leads to decreased expression of SLC26A3 on the cell membrane resulting in its reduced exchanger activity (By similarity). Q9WVC8; P26361: Cftr; NbExp=3; IntAct=EBI-6895537, EBI-6115317; Q9WVC8; P70441: Nherf1; NbExp=2; IntAct=EBI-6895537, EBI-1184085; Q9WVC8; Q8CIW6: Slc26a6; NbExp=2; IntAct=EBI-6895537, EBI-6895517; Apical cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail. Expressed in spermatogenic cells (PubMed:21976599). Expressed at high levels in cecum and colon and at lower levels in small intestine (PubMed:10428871). N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. protein binding plasma membrane integral component of plasma membrane chloride transport secondary active sulfate transmembrane transporter activity sulfate transport bicarbonate transmembrane transporter activity chloride transmembrane transporter activity sulfate transmembrane transporter activity antiporter activity anion:anion antiporter activity bicarbonate transport membrane integral component of membrane apical plasma membrane oxalate transmembrane transporter activity oxalate transport brush border membrane sperm capacitation intracellular pH elevation transmembrane transport membrane hyperpolarization cellular response to cAMP sperm midpiece anion transmembrane transport sulfate transmembrane transport chloride transmembrane transport uc007nhj.1 uc007nhj.2 uc007nhj.3 uc007nhj.4 uc007nhj.5 
ENSMUST00000001256.11 Sema6b ENSMUST00000001256.11 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B, transcript variant 2 (from RefSeq NM_001130456.1) ENSMUST00000001256.1 ENSMUST00000001256.10 ENSMUST00000001256.2 ENSMUST00000001256.3 ENSMUST00000001256.4 ENSMUST00000001256.5 ENSMUST00000001256.6 ENSMUST00000001256.7 ENSMUST00000001256.8 ENSMUST00000001256.9 NM_001130456 Q3UTK5 Q3UTK5_MOUSE Sema6b uc008dbe.1 uc008dbe.2 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane semaphorin receptor binding uc008dbe.1 uc008dbe.2 
ENSMUST00000001258.15 Uhrf1 ENSMUST00000001258.15 ubiquitin-like, containing PHD and RING finger domains, 1, transcript variant 1 (from RefSeq NM_010931.4) ENSMUST00000001258.1 ENSMUST00000001258.10 ENSMUST00000001258.11 ENSMUST00000001258.12 ENSMUST00000001258.13 ENSMUST00000001258.14 ENSMUST00000001258.2 ENSMUST00000001258.3 ENSMUST00000001258.4 ENSMUST00000001258.5 ENSMUST00000001258.6 ENSMUST00000001258.7 ENSMUST00000001258.8 ENSMUST00000001258.9 NM_010931 Np95 Q3U9D7 Q3U9P2 Q3UI74 Q3UIE6 Q3ULF2 Q3ULQ0 Q8C6F1 Q8VDF2 Q8VIA1 Q9Z1H6 UHRF1_MOUSE uc008dbp.1 uc008dbp.2 uc008dbp.3 uc008dbp.4 Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Plays a pivotal role in the establishment of correct spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with DNMT3A and DNMT3B. Interacts with DNMT1; the interaction is direct. Interacts with USP7; leading to its deubiquitination. Interacts with HDAC1, but not with HDAC2. Interacts with BLTP3A. Interacts with PML. Interacts with EHMT2. Binds hemimethylated CpG containing oligonucleotides (PubMed:15361834, PubMed:17994007, PubMed:18772888, PubMed:18772891, PubMed:19056828, PubMed:19798101, PubMed:21268065). Interacts with PRAMEL7 (PubMed:28604677). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (By similarity). Interacts with UHRF2 (By similarity). Interacts with FANCD2 (By similarity). Interacts with TET1 isoform 2; this interaction induces the recruitment of TET1 isoform 2 to replicating heterochromatin (PubMed:36056023). Nucleus te=Associated, through the YDG domain (also called SRA domain), with replicating DNA from early to late S phase, including at replicating pericentric heterochromatin (PubMed:36056023). Also localizes to euchromatic regions. In non-S- phase cells, homogenously distributed through the nucleus (PubMed:36056023). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VDF2-1; Sequence=Displayed; Name=2; IsoId=Q8VDF2-2; Sequence=VSP_044395; Expressed in thymus, testis, spleen and lung. Within testis, expressed in almost all cells except elongated spermatids. Up-regulated in proliferating cells, and down-regulated in quiescent or differentiated cells. Early induced by E1A in postmitotic cells. Down-regulated by aphidicolin. The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). The tudor-like regions simultaneously recognizes H3K9me3 through a conserved aromatic cage in the first tudor-like subdomain and unmodified H3K4 (H3K4me0) within a groove between the tandem subdomains (PubMed:21489993). The linker region plays a role in the formation of a histone H3-binding hole between the reader modules formed by the tudor- like regions and the PHD-type zinc finger by making extended contacts with the tandem tudor-like regions. The YDG domain (also named SRA domain) specifically recognizes and binds hemimethylated DNA at replication forks (DNA that is only methylated on the mother strand of replicating DNA) (PubMed:17994007). The YDG domain contains a binding pocket that accommodates the 5- methylcytosine that is flipped out of the duplex DNA. 2 specialized loops reach through the resulting gap in the DNA from both the major and the minor grooves to read the other 3 bases of the CpG duplex. The major groove loop confers both specificity for the CpG dinucleotide and discrimination against methylation of deoxycytidine of the complementary strand (PubMed:18772888). The YDG domain also recognizes and binds 5-hydroxymethylcytosine (5hmC). The RING finger is required for ubiquitin ligase activity. Phosphorylation at Ser-303 of the linker region decreases the binding to H3K9me3. Phosphorylation at Ser-639 by CDK1 during M phase impairs interaction with USP7, preventing deubiquitination and leading to degradation by the proteasome (By similarity). Ubiquitinated; which leads to proteasomal degradation. Autoubiquitinated; interaction with USP7 leads to deubiquitination and prevents degradation. Ubiquitination and degradation takes place during M phase, when phosphorylation at Ser-639 prevents interaction with USP7 and subsequent deubiquitination. Polyubiquitination may be stimulated by DNA damage. Mice display a sensitization to DNA damage and replication block, and die in mid-gestation. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin euchromatin heterochromatin core promoter proximal region sequence-specific DNA binding DNA binding ubiquitin-protein transferase activity protein binding nucleus nucleoplasm replication fork nuclear heterochromatin plasma membrane DNA repair chromatin organization ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus cell cycle zinc ion binding methyl-CpG binding maintenance of DNA methylation histone monoubiquitination nuclear matrix protein ubiquitination histone ubiquitination transferase activity cytoplasmic vesicle nucleosomal histone binding positive regulation of cellular protein metabolic process methylated histone binding histone binding identical protein binding hemi-methylated DNA-binding metal ion binding regulation of epithelial cell proliferation protein autoubiquitination ubiquitin protein ligase activity uc008dbp.1 uc008dbp.2 uc008dbp.3 uc008dbp.4 
ENSMUST00000001280.14 Gramd1a ENSMUST00000001280.14 GRAM domain containing 1A, transcript variant 2 (from RefSeq NM_027898.4) ASTRA_MOUSE D7Bwg0611e ENSMUST00000001280.1 ENSMUST00000001280.10 ENSMUST00000001280.11 ENSMUST00000001280.12 ENSMUST00000001280.13 ENSMUST00000001280.2 ENSMUST00000001280.3 ENSMUST00000001280.4 ENSMUST00000001280.5 ENSMUST00000001280.6 ENSMUST00000001280.7 ENSMUST00000001280.8 ENSMUST00000001280.9 Gramd1a Kiaa1533 NM_027898 Q3U914 Q3UD89 Q69ZH2 Q8BNF1 Q8VEF1 uc009gif.1 uc009gif.2 uc009gif.3 Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461). May play a role in tumor progression (PubMed:27585821). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome. This function in autophagy requires its cholesterol- transfer activity (By similarity). Endoplasmic reticulum membrane ; Single-pass membrane protein Cell membrane ; Single-pass membrane protein Cytoplasmic vesicle, autophagosome Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:30220461). Localizes to distinct EPCS than GRAMD2A and ESYT2/3 (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VEF1-1; Sequence=Displayed; Name=2; IsoId=Q8VEF1-2; Sequence=VSP_025467; Name=3; IsoId=Q8VEF1-3; Sequence=VSP_025468; Highly expressed in the brain. GRAM domain binds phosphatidylserine in the PM and mediates protein recruitment to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM. VASt (VAD1 Analog of StAR-related lipid transfer) domain, also known as ASTER (Greek for star) domain is a sterol-binding domain. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=AAH18554.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32472.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAE29255.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE29372.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE29897.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE30853.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE31103.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE32853.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane plasma membrane lipid transport lipid binding cholesterol binding sterol transport membrane integral component of membrane intrinsic component of endoplasmic reticulum membrane extrinsic component of cytoplasmic side of plasma membrane organelle membrane contact site cellular response to cholesterol uc009gif.1 uc009gif.2 uc009gif.3 
ENSMUST00000001304.9 Ckb ENSMUST00000001304.9 creatine kinase, brain (from RefSeq NM_021273.4) Ckb Ckbb ENSMUST00000001304.1 ENSMUST00000001304.2 ENSMUST00000001304.3 ENSMUST00000001304.4 ENSMUST00000001304.5 ENSMUST00000001304.6 ENSMUST00000001304.7 ENSMUST00000001304.8 KCRB_MOUSE NM_021273 Q04447 Q3KQP4 Q3TKI3 Q3U5P5 Q3UF71 Q9CXK6 uc007pdn.1 uc007pdn.2 uc007pdn.3 uc007pdn.4 Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:33597756). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (PubMed:33597756). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N- phosphocreatine as heat without performing any mechanical or chemical work (PubMed:33597756). Reaction=ATP + creatine = ADP + H(+) + N-phosphocreatine; Xref=Rhea:RHEA:17157, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57947, ChEBI:CHEBI:58092, ChEBI:CHEBI:456216; EC=2.7.3.2; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17158; Evidence=; Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain. Interacts with SLC12A6 (via C-terminus); the interaction may be required for SLC12A6 potassium- chloride cotransport activity (By similarity). Cytoplasm, cytosol Mitochondrion Cell membrane Note=Localizes to the mitochondria of thermogenic fat cells via the internal MTS-like signal (iMTS-L) region. Expressed in hippocampus and corpus callosum (at protein level). Strongly up-regulated in response to cold in fat cells; expression is dependent on cAMP. The internal MTS-like signal (iMTS-L) mediates targeting to mitochondria thermogenic fat cells. Conditional deletion in adipocytes leads to defective adaptive thermogenesis: defects are caused by abolition of the futile creatine cycle, thereby reducing whole-body energy expenditure and leading to predisposition to obesity. Belongs to the ATP:guanido phosphotransferase family. nucleotide binding catalytic activity creatine kinase activity protein binding ATP binding extracellular space nucleus cytoplasm mitochondrion cytosol brain development kinase activity phosphorylation transferase activity transferase activity, transferring phosphorus-containing groups cerebellum development dendrite cellular chloride ion homeostasis ubiquitin protein ligase binding neuronal cell body myelin sheath phosphocreatine biosynthetic process uc007pdn.1 uc007pdn.2 uc007pdn.3 uc007pdn.4 
ENSMUST00000001319.15 Efnb2 ENSMUST00000001319.15 ephrin B2, transcript variant 1 (from RefSeq NM_010111.6) ENSMUST00000001319.1 ENSMUST00000001319.10 ENSMUST00000001319.11 ENSMUST00000001319.12 ENSMUST00000001319.13 ENSMUST00000001319.14 ENSMUST00000001319.2 ENSMUST00000001319.3 ENSMUST00000001319.4 ENSMUST00000001319.5 ENSMUST00000001319.6 ENSMUST00000001319.7 ENSMUST00000001319.8 ENSMUST00000001319.9 Efnb2 NM_010111 Q4FJM3 Q4FJM3_MOUSE uc009kue.1 uc009kue.2 uc009kue.3 Membrane ; Single- pass type I membrane protein Belongs to the ephrin family. Lacks conserved residue(s) required for the propagation of feature annotation. cell migration involved in sprouting angiogenesis plasma membrane cell adhesion positive regulation of cell proliferation negative regulation of neuron projection development membrane integral component of membrane ephrin receptor binding ephrin receptor signaling pathway regulation of chemotaxis glutamatergic synapse presynapse assembly integral component of presynaptic membrane positive regulation of neuron death uc009kue.1 uc009kue.2 uc009kue.3 
ENSMUST00000001326.7 Sp1 ENSMUST00000001326.7 trans-acting transcription factor 1 (from RefSeq NM_013672.2) ENSMUST00000001326.1 ENSMUST00000001326.2 ENSMUST00000001326.3 ENSMUST00000001326.4 ENSMUST00000001326.5 ENSMUST00000001326.6 G3X8Q0 G3X8Q0_MOUSE NM_013672 Sp1 uc007xvo.1 uc007xvo.2 uc007xvo.3 Nucleus nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein C-terminus binding transcription factor binding positive regulation of gene expression transcriptional repressor complex cellular response to insulin stimulus protein-DNA complex histone acetyltransferase binding protein homodimerization activity histone deacetylase binding positive regulation of blood vessel endothelial cell migration sequence-specific DNA binding positive regulation by host of viral transcription transcription regulatory region DNA binding positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter repressing transcription factor binding HMG box domain binding positive regulation of hydrogen sulfide biosynthetic process positive regulation of vascular endothelial cell proliferation uc007xvo.1 uc007xvo.2 uc007xvo.3 
ENSMUST00000001327.11 Itgb7 ENSMUST00000001327.11 integrin beta 7 (from RefSeq NM_013566.2) ENSMUST00000001327.1 ENSMUST00000001327.10 ENSMUST00000001327.2 ENSMUST00000001327.3 ENSMUST00000001327.4 ENSMUST00000001327.5 ENSMUST00000001327.6 ENSMUST00000001327.7 ENSMUST00000001327.8 ENSMUST00000001327.9 ITB7_MOUSE NM_013566 P26011 Q3U2M1 Q64656 uc012aaa.1 uc012aaa.2 uc012aaa.3 Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin. Heterodimer of an alpha and a beta subunit. ITGB7/beta-7 associates with either ITGA4/alpha-4 or ITGAE/alpha-E. Integrin ITGA4/ITGB7 interacts with MADCAM1. Integrin ITGA4/ITGB7 interacts with VCAM1 and fibronectin. Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23). Cell membrane ; Single-pass type I membrane protein The VWFA domain (or beta I domain) contains three cation- binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site. The MIDAS site is required for both rolling and adhesion. The ADMIDAS site is required for rolling and mediates the negative regulatory effects of higher Ca(2+) concentration on ligand binding. The LIMBS site is required for adhesion and mediates the positive regulatory effects of low Ca(2+) concentrations on ligand binding. Belongs to the integrin beta chain family. cell-matrix adhesion involved in ameboidal cell migration integrin binding cell adhesion cell-matrix adhesion integrin-mediated signaling pathway integrin complex cell surface membrane integral component of membrane cell migration cell adhesion mediated by integrin heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading integrin alpha4-beta7 complex signaling receptor activity receptor clustering receptor complex cell adhesion molecule binding leukocyte migration leukocyte tethering or rolling T cell migration uc012aaa.1 uc012aaa.2 uc012aaa.3 
ENSMUST00000001339.6 Rrp15 ENSMUST00000001339.6 ribosomal RNA processing 15 homolog (from RefSeq NM_026041.2) ENSMUST00000001339.1 ENSMUST00000001339.2 ENSMUST00000001339.3 ENSMUST00000001339.4 ENSMUST00000001339.5 NM_026041 Q8BU28 Q922T8 Q9CWJ2 Q9CYX7 Q9D8W8 RRP15_MOUSE uc007dzq.1 uc007dzq.2 uc007dzq.3 uc007dzq.4 uc007dzq.5 This gene encodes a protein similar to budding yeast Rrp15p. Rrp15p is a component of pre-60S ribosomal particles in budding yeast, and is required for the early maturation steps of the 60S subunit. The mouse genome contains at least one pseudogene on the X chromosome. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AK169088.1, AK013204.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Citrullinated by PADI4. Belongs to the RRP15 family. molecular_function rRNA processing preribosome, large subunit precursor uc007dzq.1 uc007dzq.2 uc007dzq.3 uc007dzq.4 uc007dzq.5 
ENSMUST00000001347.7 Rnd2 ENSMUST00000001347.7 Rho family GTPase 2 (from RefSeq NM_009708.2) Arhn ENSMUST00000001347.1 ENSMUST00000001347.2 ENSMUST00000001347.3 ENSMUST00000001347.4 ENSMUST00000001347.5 ENSMUST00000001347.6 NM_009708 O35279 Q9QYM5 RND2_MOUSE Rho7 Rhon uc007lpb.1 uc007lpb.2 uc007lpb.3 May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity). Interacts with the Rho-GAP domain of RACGAP1. Interacts with UBXD5. Interacts with PRAG1 (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Lipid-anchor ; Cytoplasmic side Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome. Expressed specifically in neurons in the brain and spinal cord and also in hepatic stellate cells. Belongs to the small GTPase superfamily. Rho family. nucleotide binding acrosomal membrane GTPase activity protein binding GTP binding cytoplasm early endosome cell cortex actin filament organization small GTPase mediated signal transduction Rho protein signal transduction regulation of cell shape membrane protein kinase binding regulation of cell migration establishment or maintenance of actin cytoskeleton polarity cytoplasmic vesicle cell division site regulation of actin cytoskeleton organization intracellular membrane-bounded organelle protein N-terminus binding positive regulation of collateral sprouting actin filament bundle assembly plasma membrane uc007lpb.1 uc007lpb.2 uc007lpb.3 
ENSMUST00000001384.6 Cnn1 ENSMUST00000001384.6 calponin 1 (from RefSeq NM_009922.4) CNN1_MOUSE ENSMUST00000001384.1 ENSMUST00000001384.2 ENSMUST00000001384.3 ENSMUST00000001384.4 ENSMUST00000001384.5 NM_009922 Q08091 uc009onv.1 uc009onv.2 uc009onv.3 uc009onv.4 Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Event=Alternative splicing; Named isoforms=2; Name=Alpha; IsoId=Q08091-1; Sequence=Displayed; Name=Beta; IsoId=Q08091-2; Sequence=VSP_000755; Smooth muscle, and tissues containing significant amounts of smooth muscle. Belongs to the calponin family. actin binding calmodulin binding cytoskeleton actomyosin structure organization negative regulation of vascular smooth muscle cell proliferation uc009onv.1 uc009onv.2 uc009onv.3 uc009onv.4 
ENSMUST00000001412.17 Vps50 ENSMUST00000001412.17 VPS50 EARP/GARPII complex subunit, transcript variant 1 (from RefSeq NM_024260.5) Ccdc132 ENSMUST00000001412.1 ENSMUST00000001412.10 ENSMUST00000001412.11 ENSMUST00000001412.12 ENSMUST00000001412.13 ENSMUST00000001412.14 ENSMUST00000001412.15 ENSMUST00000001412.16 ENSMUST00000001412.2 ENSMUST00000001412.3 ENSMUST00000001412.4 ENSMUST00000001412.5 ENSMUST00000001412.6 ENSMUST00000001412.7 ENSMUST00000001412.8 ENSMUST00000001412.9 Kiaa1861 NM_024260 Q6ZPG9 Q7TSR5 Q80XR1 Q8C6D0 Q8C9I6 Q8CI71 Q99LN1 VPS50_MOUSE Vps50 uc009avc.1 uc009avc.2 uc009avc.3 uc009avc.4 Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (By similarity). The EARP complex interacts with EIPR1 (By similarity). Interacts with VPS51 and VPS53 in an EIPR1-independent manner (By similarity). Recycling endosome Membrane Note=Associates with membranes in an EIPR1-dependent manner. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CI71-1; Sequence=Displayed; Name=2; IsoId=Q8CI71-2; Sequence=VSP_028661, VSP_028662; Name=3; IsoId=Q8CI71-3; Sequence=VSP_028660, VSP_028663; Belongs to the syndetin family. Sequence=AAH02304.1; Type=Erroneous initiation; Evidence=; Sequence=BAC98268.1; Type=Erroneous initiation; Evidence=; SNARE binding endosome cytosol protein transport endocytic recycling perinuclear region of cytoplasm recycling endosome EARP complex retrograde transport, endosome to Golgi uc009avc.1 uc009avc.2 uc009avc.3 uc009avc.4 
ENSMUST00000001415.9 Apbb3 ENSMUST00000001415.9 amyloid beta precursor protein binding family B member 3, transcript variant 1 (from RefSeq NM_146085.2) APBB3_MOUSE Apbb3 ENSMUST00000001415.1 ENSMUST00000001415.2 ENSMUST00000001415.3 ENSMUST00000001415.4 ENSMUST00000001415.5 ENSMUST00000001415.6 ENSMUST00000001415.7 ENSMUST00000001415.8 Fe65l2 NM_146085 Q8R1C9 uc033hgg.1 uc033hgg.2 uc033hgg.3 uc033hgg.4 May modulate the internalization of amyloid-beta precursor protein. Interacts with APP (via intracellular domain) (By similarity). Interacts with APLP1 and APLP2 (via intracellular domain) (By similarity). Cytoplasm Nucleus beta-amyloid binding nucleus cytoplasm cytosol regulation of transcription, DNA-templated transcription factor binding actin cytoskeleton negative regulation of apoptotic process uc033hgg.1 uc033hgg.2 uc033hgg.3 uc033hgg.4 
ENSMUST00000001416.8 Hars1 ENSMUST00000001416.8 histidyl-tRNA synthetase 1 (from RefSeq NM_008214.4) ENSMUST00000001416.1 ENSMUST00000001416.2 ENSMUST00000001416.3 ENSMUST00000001416.4 ENSMUST00000001416.5 ENSMUST00000001416.6 ENSMUST00000001416.7 HARS1_MOUSE Hars NM_008214 Q3TKU3 Q61035 uc008eop.1 uc008eop.2 uc008eop.3 uc008eop.4 uc008eop.5 Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L- histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665, Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442, ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21; Evidence=; Homodimer. Cytoplasm Belongs to the class-II aminoacyl-tRNA synthetase family. nucleotide binding aminoacyl-tRNA ligase activity histidine-tRNA ligase activity ATP binding cytoplasm mitochondrion cytosol translation tRNA aminoacylation for protein translation histidyl-tRNA aminoacylation ligase activity mitochondrial translation identical protein binding uc008eop.1 uc008eop.2 uc008eop.3 uc008eop.4 uc008eop.5 
ENSMUST00000001419.10 Zmat2 ENSMUST00000001419.10 zinc finger, matrin type 2 (from RefSeq NM_025594.3) ENSMUST00000001419.1 ENSMUST00000001419.2 ENSMUST00000001419.3 ENSMUST00000001419.4 ENSMUST00000001419.5 ENSMUST00000001419.6 ENSMUST00000001419.7 ENSMUST00000001419.8 ENSMUST00000001419.9 NM_025594 Q5EBK0 Q9CPW7 ZMAT2_MOUSE uc008eos.1 uc008eos.2 uc008eos.3 Involved in pre-mRNA splicing as a component of the spliceosome. Component of the spliceosome B complex. Nucleus mRNA splicing, via spliceosome nucleic acid binding DNA binding nucleus spliceosomal complex mRNA processing zinc ion binding RNA splicing U4/U6 x U5 tri-snRNP complex metal ion binding U2-type precatalytic spliceosome uc008eos.1 uc008eos.2 uc008eos.3 
ENSMUST00000001451.11 Smg5 ENSMUST00000001451.11 SMG5 nonsense mediated mRNA decay factor (from RefSeq NM_178246.3) ENSMUST00000001451.1 ENSMUST00000001451.10 ENSMUST00000001451.2 ENSMUST00000001451.3 ENSMUST00000001451.4 ENSMUST00000001451.5 ENSMUST00000001451.6 ENSMUST00000001451.7 ENSMUST00000001451.8 ENSMUST00000001451.9 Est1b Kiaa1089 NM_178246 Q497S2 Q6ZPY2 Q8R3S4 SMG5_MOUSE Smg5 uc008put.1 uc008put.2 uc008put.3 Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity (By similarity). Interacts with TERT, PPP2CA and SMG1. Part of a complex that contains SMG1, SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1. Not detected in complexes that contain unphosphorylated UPF1. Cytoplasm Nucleus Note=Detected in cytoplasmic mRNA decay bodies. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZPY2-1; Sequence=Displayed; Name=2; IsoId=Q6ZPY2-2; Sequence=VSP_016590, VSP_016591; Sequence=BAC98096.1; Type=Erroneous initiation; Evidence=; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nucleus telomerase holoenzyme complex cytoplasm telomere maintenance via telomerase ubiquitin protein ligase binding regulation of telomere maintenance regulation of telomere maintenance via telomerase regulation of dephosphorylation telomeric DNA binding histone deacetylase binding protein phosphatase 2A binding telomerase RNA binding uc008put.1 uc008put.2 uc008put.3 
ENSMUST00000001452.14 Cct3 ENSMUST00000001452.14 chaperonin containing TCP1 subunit 3 (from RefSeq NM_009836.1) Cct3 ENSMUST00000001452.1 ENSMUST00000001452.10 ENSMUST00000001452.11 ENSMUST00000001452.12 ENSMUST00000001452.13 ENSMUST00000001452.2 ENSMUST00000001452.3 ENSMUST00000001452.4 ENSMUST00000001452.5 ENSMUST00000001452.6 ENSMUST00000001452.7 ENSMUST00000001452.8 ENSMUST00000001452.9 NM_009836 Q3U4U6 Q3U4U6_MOUSE uc008puo.1 uc008puo.2 uc008puo.3 uc008puo.4 uc008puo.5 Cytoplasm Belongs to the TCP-1 chaperonin family. nucleotide binding ATP binding cytoplasm cytosol chaperonin-containing T-complex microtubule plasma membrane protein folding positive regulation of telomere maintenance via telomerase protein stabilization unfolded protein binding positive regulation of establishment of protein localization to telomere uc008puo.1 uc008puo.2 uc008puo.3 uc008puo.4 uc008puo.5 
ENSMUST00000001456.11 Tmem79 ENSMUST00000001456.11 Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation. (from UniProt Q9D709) AK009760 ENSMUST00000001456.1 ENSMUST00000001456.10 ENSMUST00000001456.2 ENSMUST00000001456.3 ENSMUST00000001456.4 ENSMUST00000001456.5 ENSMUST00000001456.6 ENSMUST00000001456.7 ENSMUST00000001456.8 ENSMUST00000001456.9 Matt Q9D709 TMM79_MOUSE uc008pur.1 uc008pur.2 uc008pur.3 Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation. Lysosome Golgi apparatus, trans-Golgi network Membrane ; Multi-pass membrane protein Note=Colocalized with TGOLN2 in the trans-Golgi network. Colocalized with LAMP1 in the lysosome. Expressed in the epidermis of the skin. Expressed in epithelial cells of the outermost layer of the stratum granulosum (SG) and in hair follicles (at protein level). Note=Defects in Tmem79 are the cause of the spontaneous matted (matt) mutant phenotype, a model for human atopic dermatitis. Atopic dermatitis (ma/ma) mice have a matted hair phenotype with progressive dermatitis-like skin inflammation and a scratching behavior. Mice display an altered skin barrier that facilitates allergic sensitization. epithelial cell maturation cytoplasm lysosome lysosomal membrane Golgi apparatus membrane integral component of membrane hair follicle morphogenesis trans-Golgi network membrane cuticle development identical protein binding regulated exocytosis positive regulation of epidermis development establishment of skin barrier cornification uc008pur.1 uc008pur.2 uc008pur.3 
ENSMUST00000001460.14 Snd1 ENSMUST00000001460.14 staphylococcal nuclease and tudor domain containing 1 (from RefSeq NM_019776.2) ENSMUST00000001460.1 ENSMUST00000001460.10 ENSMUST00000001460.11 ENSMUST00000001460.12 ENSMUST00000001460.13 ENSMUST00000001460.2 ENSMUST00000001460.3 ENSMUST00000001460.4 ENSMUST00000001460.5 ENSMUST00000001460.6 ENSMUST00000001460.7 ENSMUST00000001460.8 ENSMUST00000001460.9 NM_019776 Q3TT46 Q78PY7 Q922L5 Q9R0S1 SND1_MOUSE uc009bct.1 uc009bct.2 Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (By similarity). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (By similarity). Functions as a bridging factor between STAT6 and the basal transcription factor (By similarity). Plays a role in PIM1 regulation of MYB activity (By similarity). Functions as a transcriptional coactivator for STAT5 (PubMed:12819296). Reaction=Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'- phosphooligonucleotide end-products.; EC=3.1.31.1; Evidence=; Forms a ternary complex with STAT6 and POLR2A (By similarity). Associates with the RNA-induced silencing complex (RISC) (PubMed:24882364). Interacts with the RISC components AGO2, FMR1 and TNRC6A. Interacts with GTF2E1 and GTF2E2 (By similarity). Interacts with PIM1 (By similarity). Interacts with STAT5 (PubMed:12819296). Interacts with SYT11 (via C2 2 domain); the interaction with SYT11 is direct (PubMed:24882364). Q78PY7; Q80WJ7: Mtdh; NbExp=4; IntAct=EBI-529864, EBI-774530; Cytoplasm Nucleus Melanosome Note=In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Phosphorylated by PIM1 in vitro. Sequence=BAA84944.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleic acid binding RNA binding nuclease activity endonuclease activity endoribonuclease activity protein binding nucleus cytoplasm mitochondrion cytosol RNA catabolic process regulation of cell cycle process miRNA catabolic process RISC complex hydrolase activity gene silencing by RNA melanosome nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic dense body RISC complex binding uc009bct.1 uc009bct.2 
ENSMUST00000001479.5 Kpnb1 ENSMUST00000001479.5 karyopherin subunit beta 1 (from RefSeq NM_008379.3) ENSMUST00000001479.1 ENSMUST00000001479.2 ENSMUST00000001479.3 ENSMUST00000001479.4 IMB1_MOUSE Impnb NM_008379 P70168 Q62117 Q6GTI5 uc007ldu.1 uc007ldu.2 uc007ldu.3 Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In association with IPO7, mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Imports SNAI1 and PRKCI into the nucleus (By similarity). Forms a complex with an importin alpha subunit (By similarity). Interacts with XPO1 (By similarity). Forms a heterodimer with IPO7 (By similarity). The KPNB1/IPO7 heterodimer interacts with H1 histone (By similarity). Interacts with SNUPN (By similarity). Interacts with H2A, H2B, H3 and H4 histones (PubMed:11493596). Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259 (By similarity). Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1 (By similarity). Interacts with SRY (PubMed:11535586). Interacts with PRKCI/atypical protein kinase C iota (By similarity). Interacts with KPNA2 (By similarity). Interacts with KPNA7 (PubMed:20699224). Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers) (By similarity). Interacts with SLC35G1 and STIM1 (By similarity). Interacts with DCAF8 (By similarity). Interacts with RAN (PubMed:25946333). Interacts with NUMA1 (via C- terminus); this interaction is inhibited by RanGTP (By similarity). Interacts with ZBED1/hDREF; required for nuclear import of ZBED1/hDREF (By similarity). Interacts with SRP19 (By similarity). Interacts with RPL23A (via BIB domain), RPS7 and RPL5 (By similarity). Interacts with PARP16 (By similarity). P70168; P49790: NUP153; Xeno; NbExp=2; IntAct=EBI-540580, EBI-286779; Cytoplasm Nucleus envelope Mono-ADP-ribosylated by PARP16. Belongs to the importin beta family. Importin beta-1 subfamily. protein binding nucleus nuclear envelope nuclear pore nucleoplasm cytoplasm cytosol protein import into nucleus ribosomal protein import into nucleus intracellular protein transport mitotic chromosome movement towards spindle pole mitotic metaphase plate congression nuclear localization sequence binding Ran GTPase binding cytoplasmic stress granule protein transport kinesin binding enzyme binding protein domain specific binding astral microtubule organization Ran protein signal transduction nuclear membrane macromolecular complex establishment of mitotic spindle localization macromolecular complex binding establishment of protein localization Hsp90 protein binding nuclear import signal receptor activity importin-alpha family protein binding endoplasmic reticulum tubular network mitotic spindle assembly uc007ldu.1 uc007ldu.2 uc007ldu.3 
ENSMUST00000001480.14 Npepps ENSMUST00000001480.14 aminopeptidase puromycin sensitive (from RefSeq NM_008942.3) ENSMUST00000001480.1 ENSMUST00000001480.10 ENSMUST00000001480.11 ENSMUST00000001480.12 ENSMUST00000001480.13 ENSMUST00000001480.2 ENSMUST00000001480.3 ENSMUST00000001480.4 ENSMUST00000001480.5 ENSMUST00000001480.6 ENSMUST00000001480.7 ENSMUST00000001480.8 ENSMUST00000001480.9 NM_008942 PSA_MOUSE Psa Q11011 Q3UZE0 Q5PR74 Q91VJ8 uc007ldv.1 uc007ldv.2 uc007ldv.3 uc007ldv.4 uc007ldv.5 Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Reaction=Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.; EC=3.4.11.14; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Strongly inhibited by bestatin, leuhistin, actinonin, amastatin, 1,10-phenanthroline, DFP, PCMBS, Zn(2+), Cd(2+), Co(2+), Cu(2+), Hg(2+), EDTA and puromycin. Not inhibited by PMSF, and only slightly inhibited by leupeptin and aprotinin. Activity is increased by Mg(2+) and Ca(2+) (By similarity). Monomer. Cytoplasm, cytosol Nucleus Widely expressed. Highest expression in brain, particularly the striatum and hippocampus. Expressed in Sertoli cells. Mice exhibit dwarfism, increased anxiety, impaired pain responses and do not reproduce as well as wild-type mice. More MHC class I molecules are displayed on dendritic cell surfaces. Belongs to the peptidase M1 family. It is uncertain whether Met-1 or Met-46 is the initiator. aminopeptidase activity nucleus cytoplasm cytosol proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity peptide binding peptide catabolic process metal ion binding metalloaminopeptidase activity cellular response to hypoxia uc007ldv.1 uc007ldv.2 uc007ldv.3 uc007ldv.4 uc007ldv.5 
ENSMUST00000001484.3 Tbx21 ENSMUST00000001484.3 T-box 21 (from RefSeq NM_019507.2) ENSMUST00000001484.1 ENSMUST00000001484.2 NM_019507 Q3U150 Q9JKD8 Q9R0A6 TBX21_MOUSE Tbet Tblym uc007ldr.1 uc007ldr.2 uc007ldr.3 uc007ldr.4 Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs. Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4- containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (PubMed:10761931, PubMed:17923685, PubMed:21095589). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC (PubMed:21151104). Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2 (PubMed:15662016, PubMed:21690296, PubMed:23616576). Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN- stimulated genes (PubMed:28623086). Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (PubMed:27430722). Interacts with RUNX1 and RUNX3 (PubMed:21151104). Interacts with ITK (PubMed:15662016). The phosphorylated form (at Tyr-525) interacts with GATA3 (PubMed:15662016, PubMed:21690296, PubMed:23616576). Interacts with ABL1 (PubMed:21690296). Interacts with RELA (PubMed:23616576). The phosphorylated form (at Thr-302) interacts with NFATC2 (PubMed:23616576). Interacts with KDM6B (PubMed:21095589). Interacts with SMARCA4 in a KDM6B-dependent manner (PubMed:21095589). Interacts with CCTN1 and CDK9 (PubMed:27292648). Interacts with USP10 (By similarity). Q9JKD8; P41183: Bcl6; NbExp=3; IntAct=EBI-3863870, EBI-6253762; Q9JKD8; Q03347: Runx1; NbExp=3; IntAct=EBI-3863870, EBI-3863873; Nucleus T-cell specific (PubMed:10761931, PubMed:11087660). Expressed in regulatory T (TReg) cells (PubMed:28607488). Induced during early Th1 cell differentiation, gradually decreasing at later stages. Phosphorylations at Ser-52, Tyr-76, Ser-224 and Ser-508 are regulated by mTORC1 (PubMed:28424242). Phosphorylation at Tyr-525 is essential for its interaction GATA3 (PubMed:15662016). Phosphorylation at Tyr-219, Tyr-265 and Tyr-304 enhances its transcriptional activator activity (PubMed:21690296). Phosphorylation at Thr-302 is required for its interaction with NFATC2 (PubMed:23616576). Ubiquitinated at Lys-313, leading to its degradation by the proteasome. Ubiquitination is essential for controlling protein stability, binding to the T-box-binding element of the IFN-gamma promoter, and for interaction with NFATC2 through induction of phosphorylation at Thr-302 (PubMed:23616576). Deubiquitinated by USP10 leading to its stabilization (By similarity). negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cell fate specification heart looping DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated response to virus positive regulation of gene expression T cell differentiation negative regulation of interleukin-2 production neuronal cell body proteasome-mediated ubiquitin-dependent protein catabolic process sequence-specific DNA binding transcription regulatory region DNA binding regulation of T cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgG isotypes regulation of immune response cellular response to organic substance lymphocyte migration negative regulation of T-helper 17 cell differentiation negative regulation of T-helper 17 cell lineage commitment negative regulation of T-helper 2 cell cytokine production uc007ldr.1 uc007ldr.2 uc007ldr.3 uc007ldr.4 
ENSMUST00000001485.10 Mrpl10 ENSMUST00000001485.10 mitochondrial ribosomal protein L10, transcript variant 1 (from RefSeq NM_026154.3) ENSMUST00000001485.1 ENSMUST00000001485.2 ENSMUST00000001485.3 ENSMUST00000001485.4 ENSMUST00000001485.5 ENSMUST00000001485.6 ENSMUST00000001485.7 ENSMUST00000001485.8 ENSMUST00000001485.9 NM_026154 Q3TBW2 Q9CQD2 RM10_MOUSE uc007ldm.1 uc007ldm.2 uc007ldm.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uL10 family. structural constituent of ribosome nucleoplasm mitochondrion mitochondrial large ribosomal subunit ribosome translation large ribosomal subunit ribosome biogenesis ribonucleoprotein complex uc007ldm.1 uc007ldm.2 uc007ldm.3 
ENSMUST00000001497.9 Cideb ENSMUST00000001497.9 cell death-inducing DNA fragmentation factor, alpha subunit-like effector B (from RefSeq NM_009894.3) CIDEB_MOUSE Cideb ENSMUST00000001497.1 ENSMUST00000001497.2 ENSMUST00000001497.3 ENSMUST00000001497.4 ENSMUST00000001497.5 ENSMUST00000001497.6 ENSMUST00000001497.7 ENSMUST00000001497.8 NM_009894 O70303 Q91X39 uc007uap.1 uc007uap.2 uc007uap.3 uc007uap.4 uc007uap.5 Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:26733203). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:26733203). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity). Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet- containing hepatocytes (PubMed:26733203). In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport (PubMed:19187774, PubMed:23297397, PubMed:30858281). Required for very-low-density lipoprotein (VLDL) lipidation and maturation (PubMed:19187774, PubMed:23297397). Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles (PubMed:23297397). Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles (PubMed:30858281). May also activate apoptosis (PubMed:9564035). Interacts with DFFA (By similarity). Interacts with DFFB; inhibited by DFFB (By similarity). Interacts with APOB (PubMed:19187774, PubMed:23297397). Interacts with PREB/SEC12; facilitating loading of SCAP-SREBP into COPII vesicles (PubMed:30858281). Lipid droplet doplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus Cytoplasmic vesicle, COPI-coated vesicle Note=Enriched at lipid droplet contact sites. Highly enriched in the liver. Mice display lower levels of plasma triglycerides and free fatty acids and show smaller lipid droplets in hepatocytes (PubMed:17646209, PubMed:19187774). Mice are resistant to high-fat diet-induced obesity and are protected against hepatic steatosis (PubMed:17646209). Mice also show decreased very-low-density lipoprotein (VLDL)-triacylglycerol secretion and reduced VLDL size (PubMed:19187774). Belongs to the CIDE family. lipid particle cytosol apoptotic process positive regulation of cell death identical protein binding perinuclear region of cytoplasm positive regulation of release of cytochrome c from mitochondria execution phase of apoptosis activation of cysteine-type endopeptidase activity uc007uap.1 uc007uap.2 uc007uap.3 uc007uap.4 uc007uap.5 
ENSMUST00000001507.5 Cyp51 ENSMUST00000001507.5 cytochrome P450, family 51 (from RefSeq NM_020010.2) CP51A_MOUSE Cyp51a1 ENSMUST00000001507.1 ENSMUST00000001507.2 ENSMUST00000001507.3 ENSMUST00000001507.4 NM_020010 Q8BSQ7 Q8K0C4 Q9JIP8 Q9JIY3 uc008wie.1 uc008wie.2 uc008wie.3 Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis (PubMed:21705796). Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta- 8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta- 8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis (PubMed:21705796). Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL (By similarity). Reaction=a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-- hemoprotein reductase] = a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:54028, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:138029, ChEBI:CHEBI:138031; EC=1.14.14.154; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54029; Evidence=; Reaction=lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:25286, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740, ChEBI:CHEBI:16521, ChEBI:CHEBI:17813, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.154; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25287; Evidence=; Reaction=24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:45960, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740, ChEBI:CHEBI:28113, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78904; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45961; Evidence=; Reaction=a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:68060, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:138029, ChEBI:CHEBI:176901; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68061; Evidence=; Reaction=a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH-- hemoprotein reductase] = a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:68064, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:176901, ChEBI:CHEBI:176902; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68065; Evidence=; Reaction=a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:68068, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:138031, ChEBI:CHEBI:176902; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68069; Evidence=; Reaction=lanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32- hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:75103, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16521, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:166806; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75104; Evidence=; Reaction=32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:75107, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:166681, ChEBI:CHEBI:166806; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75108; Evidence=; Reaction=32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:75111, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740, ChEBI:CHEBI:17813, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:166681; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75112; Evidence=; Reaction=24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:75079, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:28113, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87057; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75080; Evidence=; Reaction=32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH-- hemoprotein reductase] = 32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:75087, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87057, ChEBI:CHEBI:87060; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75088; Evidence=; Reaction=32-oxo-24,25-dihydrolanosterol + O2 + reduced [NADPH-- hemoprotein reductase] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:75083, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78904, ChEBI:CHEBI:87060; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75084; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Inhibited by azalanstat. Inhibited by azole antifungal agents ketoconazole, itraconazole and fluconazole. Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6. Endoplasmic reticulum membrane ; Single-pass membrane protein Microsome membrane ; Single-pass membrane protein Embryonic lethality at 15 dpc, likely due to heart failure. Mutant mice present complete block of de novo cholesterol synthesis at 14.5 dpc. Heart abnormalities include hypoplasia combined with ventricle septum and epicardial and vasculogenesis defects. Skeletal abnormalities include facial hypoplasia, brachycephaly, and bowed and jointed bones of the extremities with camptodactyly. Can serve as an animal model for studying Antley-Bixler syndrome. Belongs to the cytochrome P450 family. Sequence=AAF73986.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process steroid metabolic process cholesterol metabolic process sterol 14-demethylase activity membrane integral component of membrane sterol metabolic process sterol biosynthetic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding organelle membrane cholesterol biosynthetic process via 24,25-dihydrolanosterol negative regulation of protein catabolic process intracellular membrane-bounded organelle metal ion binding negative regulation of protein secretion oxidation-reduction process demethylation negative regulation of beta-amyloid clearance uc008wie.1 uc008wie.2 uc008wie.3 
ENSMUST00000001513.8 Tubb6 ENSMUST00000001513.8 tubulin, beta 6 class V (from RefSeq NM_026473.2) ENSMUST00000001513.1 ENSMUST00000001513.2 ENSMUST00000001513.3 ENSMUST00000001513.4 ENSMUST00000001513.5 ENSMUST00000001513.6 ENSMUST00000001513.7 NM_026473 Q922F4 TBB6_MOUSE uc008fmd.1 uc008fmd.2 uc008fmd.3 uc008fmd.4 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Cytoplasm, cytoskeleton The highly acidic C-terminal region may bind cations such as calcium. The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation. Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility (PubMed:33414192). Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:15890843). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (PubMed:23897886). Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle GTPase activity structural constituent of cytoskeleton GTP binding cytoplasm cytoskeleton microtubule microtubule-based process uc008fmd.1 uc008fmd.2 uc008fmd.3 uc008fmd.4 
ENSMUST00000001520.13 Afg3l1 ENSMUST00000001520.13 AFG3-like AAA ATPase 1, transcript variant 1 (from RefSeq NM_054070.3) AFG31_MOUSE ENSMUST00000001520.1 ENSMUST00000001520.10 ENSMUST00000001520.11 ENSMUST00000001520.12 ENSMUST00000001520.2 ENSMUST00000001520.3 ENSMUST00000001520.4 ENSMUST00000001520.5 ENSMUST00000001520.6 ENSMUST00000001520.7 ENSMUST00000001520.8 ENSMUST00000001520.9 NM_054070 Q3THK2 Q6PGJ7 Q920A7 Q9CZN2 uc009nwd.1 uc009nwd.2 uc009nwd.3 uc009nwd.4 Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Homooligomer (PubMed:17101804). Forms heterooligomers with SPG7 and AFG3L2 (PubMed:17101804, PubMed:19656850). Interacts with SPG7 and AFG3L2 (PubMed:19656850). Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q920A7-1; Sequence=Displayed; Name=2; IsoId=Q920A7-2; Sequence=VSP_031809, VSP_031810; In the N-terminal section; belongs to the AAA ATPase family. In the C-terminal section; belongs to the peptidase M41 family. The orthologous human gene is a pseudogene. Sequence=AAK66971.1; Type=Erroneous initiation; Evidence=; Sequence=BAB28211.3; Type=Frameshift; Evidence=; nucleotide binding metalloendopeptidase activity protein binding ATP binding mitochondrion mitochondrial inner membrane m-AAA complex proteolysis mitochondrion organization mitochondrial fusion peptidase activity metallopeptidase activity zinc ion binding membrane integral component of membrane protein processing hydrolase activity mitochondrial protein processing cristae formation metal ion binding uc009nwd.1 uc009nwd.2 uc009nwd.3 uc009nwd.4 
ENSMUST00000001534.7 Sost ENSMUST00000001534.7 sclerostin (from RefSeq NM_024449.6) B2RQA5 ENSMUST00000001534.1 ENSMUST00000001534.2 ENSMUST00000001534.3 ENSMUST00000001534.4 ENSMUST00000001534.5 ENSMUST00000001534.6 NM_024449 Q99P68 Q9D3L7 SOST_MOUSE Sost uc011yfn.1 uc011yfn.2 Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6. Secreted, extracellular space, extracellular matrix Mice were resistant to mechanical unloading- induced bone loss. Belongs to the sclerostin family. ossification protein binding extracellular region extracellular space Golgi apparatus transcription factor binding heparin binding Wnt signaling pathway negative regulation of Wnt signaling pathway negative regulation of ossification negative regulation of BMP signaling pathway negative regulation of protein complex assembly macromolecular complex positive regulation of transcription, DNA-templated cellular response to parathyroid hormone stimulus negative regulation of canonical Wnt signaling pathway uc011yfn.1 uc011yfn.2 
ENSMUST00000001536.9 Nkx2-1 ENSMUST00000001536.9 NK2 homeobox 1, transcript variant 1 (from RefSeq NM_009385.4) ENSMUST00000001536.1 ENSMUST00000001536.2 ENSMUST00000001536.3 ENSMUST00000001536.4 ENSMUST00000001536.5 ENSMUST00000001536.6 ENSMUST00000001536.7 ENSMUST00000001536.8 NKX21_MOUSE NM_009385 Nkx-2.1 Nkx2-1 P50220 Titf1 Ttf1 uc007npg.1 uc007npg.2 uc007npg.3 uc007npg.4 uc007npg.5 Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (PubMed:22955271). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (PubMed:22356123). Interacts with WWTR1. Nucleus Thyroid, lung and brain. Expressed in lung at least from to 9.5 dpc to adulthood. Phosphorylated on serine residues by STK3/MST2. Belongs to the NK-2 homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II regulatory region DNA binding core promoter binding intronic transcription regulatory region sequence-specific DNA binding neuron migration regulation of blood volume by renin-angiotensin DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter phospholipid metabolic process pattern specification process axon guidance brain development endoderm development locomotory behavior feeding behavior transcription factor binding response to hormone animal organ morphogenesis positive regulation of gene expression negative regulation of epithelial to mesenchymal transition TBP-class protein binding enzyme binding telencephalon development globus pallidus development hippocampus development cerebral cortex cell migration forebrain dorsal/ventral pattern formation forebrain neuron fate commitment forebrain neuron differentiation cerebral cortex GABAergic interneuron differentiation cerebral cortex neuron differentiation pituitary gland development telencephalon cell migration cell differentiation lung development negative regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway thyroid gland development forebrain development developmental induction response to lipopolysaccharide Leydig cell differentiation hyperosmotic salinity response positive regulation of circadian rhythm protein homodimerization activity sequence-specific DNA binding transcription regulatory region DNA binding intronic transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process anatomical structure formation involved in morphogenesis neuron fate commitment oligodendrocyte differentiation lung saccule development epithelial tube branching involved in lung morphogenesis Clara cell differentiation Type II pneumocyte differentiation uc007npg.1 uc007npg.2 uc007npg.3 uc007npg.4 uc007npg.5 
ENSMUST00000001544.12 Vwa5a ENSMUST00000001544.12 von Willebrand factor A domain containing 5A, transcript variant 1 (from RefSeq NM_172767.3) ENSMUST00000001544.1 ENSMUST00000001544.10 ENSMUST00000001544.11 ENSMUST00000001544.2 ENSMUST00000001544.3 ENSMUST00000001544.4 ENSMUST00000001544.5 ENSMUST00000001544.6 ENSMUST00000001544.7 ENSMUST00000001544.8 ENSMUST00000001544.9 Loh11cr2a NM_172767 Q3TTU2 Q3UVU1 Q3V3F2 Q6UN22 Q8BHA8 Q99KC8 Q9CTV9 VMA5A_MOUSE uc012grc.1 uc012grc.2 May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in may contribute directly to or modify tumorigenesis (By similarity). extracellular matrix structural constituent nucleus nucleoplasm biological_process uc012grc.1 uc012grc.2 
ENSMUST00000001547.8 Col1a1 ENSMUST00000001547.8 collagen, type I, alpha 1 (from RefSeq NM_007742.4) CO1A1_MOUSE Col1a1 Cola1 ENSMUST00000001547.1 ENSMUST00000001547.2 ENSMUST00000001547.3 ENSMUST00000001547.4 ENSMUST00000001547.5 ENSMUST00000001547.6 ENSMUST00000001547.7 NM_007742 P11087 Q53WT0 Q60635 Q61367 Q61427 Q63919 Q6PCL3 Q810J9 uc007kzn.1 uc007kzn.2 uc007kzn.3 This gene encodes the alpha-1 subunit of the fibril-forming type I collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-2 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice lacking the encoded protein die in utero caused by the rupture of a major blood vessel. Transgenic mice expressing significantly lower levels of this gene exhibit morphological and functional defects in mineralized and non-mineralized connective tissue and, progressive loss of hearing. [provided by RefSeq, Nov 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK159285.1, BC050014.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Type I collagen is a member of group I collagen (fibrillar forming collagen). Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts with MRC2. Interacts with TRAM2. Interacts with MFAP4 in a Ca (2+)- dependent manner. Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11087-1; Sequence=Displayed; Name=2; IsoId=P11087-2; Sequence=VSP_016548; Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite. Expressed in early bell stage dental mesenchymal cells at 15.5 dpc (at protein level) (PubMed:24028588). Expressed in bell stage dental mesenchymal cells at 17.5 dpc (PubMed:29148101). The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity). Contains mostly 4-hydroxyproline. Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline. Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains. O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide. Belongs to the fibrillar collagen family. Sequence=CAA38657.1; Type=Erroneous gene model prediction; Evidence=; skeletal system development ossification blood vessel development osteoblast differentiation intramembranous ossification endochondral ossification protease binding extracellular matrix structural constituent protein binding extracellular region collagen trimer collagen type I trimer extracellular space cytoplasm endoplasmic reticulum Golgi apparatus response to nutrient visual perception sensory perception of sound response to mechanical stimulus positive regulation of epithelial to mesenchymal transition negative regulation of cell-substrate adhesion protein transport extracellular matrix structural constituent conferring tensile strength secretory granule extracellular matrix organization collagen fibril organization positive regulation of cell migration extracellular matrix response to nutrient levels response to corticosteroid response to estradiol collagen biosynthetic process protein localization to nucleus tooth mineralization collagen-activated tyrosine kinase receptor signaling pathway wound healing response to drug response to hydrogen peroxide identical protein binding response to peptide hormone skin development skin morphogenesis cellular response to fibroblast growth factor stimulus tooth eruption positive regulation of transcription, DNA-templated metal ion binding platelet-derived growth factor binding response to steroid hormone skeletal system morphogenesis embryonic skeletal system development response to cAMP response to hyperoxia face morphogenesis bone trabecula formation cartilage development involved in endochondral bone morphogenesis cellular response to amino acid stimulus cellular response to mechanical stimulus cellular response to retinoic acid cellular response to vitamin E cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway response to fluoride cellular response to fluoride uc007kzn.1 uc007kzn.2 uc007kzn.3 
ENSMUST00000001548.14 Itga3 ENSMUST00000001548.14 integrin alpha 3, transcript variant 1 (from RefSeq NM_013565.3) ENSMUST00000001548.1 ENSMUST00000001548.10 ENSMUST00000001548.11 ENSMUST00000001548.12 ENSMUST00000001548.13 ENSMUST00000001548.2 ENSMUST00000001548.3 ENSMUST00000001548.4 ENSMUST00000001548.5 ENSMUST00000001548.6 ENSMUST00000001548.7 ENSMUST00000001548.8 ENSMUST00000001548.9 ITA3_MOUSE NM_013565 Q08441 Q08442 Q5SWA8 Q5SWB9 Q62470 Q6P6I1 uc007kzw.1 uc007kzw.2 uc007kzw.3 uc007kzw.4 This gene encodes a subunit of integrin family of cell surface proteins. The encoded protein undergoes post-translational processing to form a disulfide bond-linked dimer comprised of heavy and light chains. At the cell surface, the encoded protein non-covalently associates with the integrin beta-1 subunit to form a heterodimer that interacts with many extracellular matrix proteins including fibronectin and laminin. Mice lacking the encoded protein die during the first day after birth due to severe abnormalities in kidneys. Mice lacking the encoded protein specifically in the basal layer of epidermis display several skin defects and accelerated wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha- 3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner. Q62470; O35566: Cd151; NbExp=2; IntAct=EBI-8398907, EBI-8369654; Q62470; P28828: Ptprm; NbExp=3; IntAct=EBI-8398907, EBI-8539266; Cell membrane; Single-pass type I membrane protein. Cell membrane ; Lipid-anchor Cell projection, invadopodium membrane ; Single-pass type I membrane protein Cell projection, filopodium membrane ; Single-pass type I membrane protein Note=Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha-3A; IsoId=Q62470-1; Sequence=Displayed; Name=2; Synonyms=Alpha-3B; IsoId=Q62470-2; Sequence=VSP_002722; Name=3; IsoId=Q62470-3; Sequence=VSP_041797; Isoform 1 and isoform 2 are expressed in heart and brain. Only isoform 1 is detected in lung. Belongs to the integrin alpha chain family. neuron migration fibronectin binding protease binding integrin binding protein binding collagen binding plasma membrane cell adhesion integrin-mediated signaling pathway heart development memory integrin complex external side of plasma membrane cell surface positive regulation of gene expression positive regulation of epithelial cell migration positive regulation of cell-substrate adhesion positive regulation of neuron projection development membrane integral component of membrane basolateral plasma membrane regulation of transforming growth factor beta receptor signaling pathway protein domain specific binding cell junction regulation of Wnt signaling pathway lung development growth cone regulation of BMP signaling pathway negative regulation of cell projection organization filopodium membrane integrin alpha3-beta1 complex response to gonadotropin negative regulation of Rho protein signal transduction exploration behavior response to drug cell projection receptor complex laminin binding skin development synapse protein heterodimerization activity mesodermal cell differentiation perinuclear region of cytoplasm excitatory synapse maternal process involved in female pregnancy invadopodium membrane cell periphery nephron development synaptic membrane dendritic spine maintenance renal filtration positive regulation of protein localization to plasma membrane growth cone filopodium fusion of sperm to egg plasma membrane uc007kzw.1 uc007kzw.2 uc007kzw.3 uc007kzw.4 
ENSMUST00000001559.11 Itfg2 ENSMUST00000001559.11 integrin alpha FG-GAP repeat containing 2 (from RefSeq NM_133927.1) ENSMUST00000001559.1 ENSMUST00000001559.10 ENSMUST00000001559.2 ENSMUST00000001559.3 ENSMUST00000001559.4 ENSMUST00000001559.5 ENSMUST00000001559.6 ENSMUST00000001559.7 ENSMUST00000001559.8 ENSMUST00000001559.9 ITFG2_MOUSE Itfg2 NM_133927 Q3UYJ5 Q8R148 Q91WI7 uc009edo.1 uc009edo.2 uc009edo.3 As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. Part of the KICSTOR complex composed of KPTN, ITFG2, KICS2 and SZT2. SZT2 probably serves as a link between the other three proteins in the KICSTOR complex and may mediate the direct interaction with the GATOR complex via GATOR1. The KICSTOR complex interacts directly with the GATOR1 complex and most probably indirectly with the GATOR2 complex in an amino acid-independent manner. Lysosome membrane Note=Localization to lysosomes is amino acid-independent. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91WI7-1; Sequence=Displayed; Name=2; IsoId=Q91WI7-2; Sequence=VSP_026003; germinal center B cell differentiation molecular_function nucleoplasm lysosome lysosomal membrane cytosol membrane cellular response to amino acid starvation cellular response to glucose starvation negative regulation of TORC1 signaling uc009edo.1 uc009edo.2 uc009edo.3 
ENSMUST00000001561.12 Nrip2 ENSMUST00000001561.12 nuclear receptor interacting protein 2, transcript variant 2 (from RefSeq NM_021717.3) ENSMUST00000001561.1 ENSMUST00000001561.10 ENSMUST00000001561.11 ENSMUST00000001561.2 ENSMUST00000001561.3 ENSMUST00000001561.4 ENSMUST00000001561.5 ENSMUST00000001561.6 ENSMUST00000001561.7 ENSMUST00000001561.8 ENSMUST00000001561.9 NM_021717 NRIP2_MOUSE Nix1 Q14BZ2 Q3U0V7 Q3UYH0 Q9JHR9 uc009edn.1 uc009edn.2 uc009edn.3 uc009edn.4 Down-regulates transcriptional activation by nuclear receptors, such as NR1F2. Interacts with NR1F2, RARA and THRB in a ligand-dependent manner. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JHR9-1; Sequence=Displayed; Name=2; IsoId=Q9JHR9-2; Sequence=VSP_022275; Expression is restricted to the central nervous system (neurons in the dentate gyrus of the hippocampus, the amygdala, thalamic and hypothalamic regions). Sequence=BAE22242.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter aspartic-type endopeptidase activity protein binding nucleus cytoplasm proteolysis Notch signaling pathway uc009edn.1 uc009edn.2 uc009edn.3 uc009edn.4 
ENSMUST00000001562.9 Tulp3 ENSMUST00000001562.9 TUB like protein 3 (from RefSeq NM_011657.2) ENSMUST00000001562.1 ENSMUST00000001562.2 ENSMUST00000001562.3 ENSMUST00000001562.4 ENSMUST00000001562.5 ENSMUST00000001562.6 ENSMUST00000001562.7 ENSMUST00000001562.8 NM_011657 O88413 TULP3_MOUSE Tulp3 uc009edh.1 uc009edh.2 Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT- A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes. Associates with the IFT complex A (IFT-A) (By similarity). Interacts with SIRT1 (By similarity). Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm. Secreted. Note=Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha (By similarity). Does not have a cleavable signal peptide and is secreted by a non-conventional pathway. Widely expressed including eyes and adipose depots. Ubiquitously expressed during development. Failure of neural tube closure and death by embryonic day 14.5. Failure of cranial neural tube closure coincident with increased neuroepithelial apoptosis specifically in the hindbrain and the caudal neural tube. In addition, the number of tubulin beta-3 positive cells is significantly decreased in the embryonic hindbrain. Morphological defects in the embryonic craniofacial regions, the spinal neural tube and the limbs. Belongs to the TUB family. G-protein coupled receptor binding neural tube formation neural tube closure extracellular region nucleus nucleolus cytoplasm plasma membrane cilium axoneme multicellular organism development brain development regulation of G-protein coupled receptor protein signaling pathway regulation of smoothened signaling pathway anterior/posterior pattern specification membrane enzyme binding dorsal/ventral neural tube patterning negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning neural tube development central nervous system neuron differentiation embryonic camera-type eye development phosphatidylinositol binding embryonic digit morphogenesis cell projection macromolecular complex binding negative regulation of smoothened signaling pathway embryonic neurocranium morphogenesis limb development bone development bronchus morphogenesis smoothened signaling pathway involved in dorsal/ventral neural tube patterning protein localization to cilium ganglion development ciliary base 9+0 non-motile cilium negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning uc009edh.1 uc009edh.2 
ENSMUST00000001565.15 Gtf2h4 ENSMUST00000001565.15 general transcription factor II H, polypeptide 4, transcript variant 9 (from RefSeq NR_182136.1) ENSMUST00000001565.1 ENSMUST00000001565.10 ENSMUST00000001565.11 ENSMUST00000001565.12 ENSMUST00000001565.13 ENSMUST00000001565.14 ENSMUST00000001565.2 ENSMUST00000001565.3 ENSMUST00000001565.4 ENSMUST00000001565.5 ENSMUST00000001565.6 ENSMUST00000001565.7 ENSMUST00000001565.8 ENSMUST00000001565.9 Gtf2h4 NR_182136 Q542U3 Q542U3_MOUSE uc008cig.1 uc008cig.2 uc008cig.3 uc008cig.4 Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Nucleus Belongs to the TFB2 family. core TFIIH complex portion of holo TFIIH complex core TFIIH complex ATPase activator activity protein kinase activity nucleus transcription factor TFIID complex holo TFIIH complex DNA repair nucleotide-excision repair transcription from RNA polymerase II promoter protein phosphorylation cellular response to DNA damage stimulus DNA-dependent ATPase activity RNA polymerase II carboxy-terminal domain kinase activity obsolete general RNA polymerase II transcription factor activity nuclear speck positive regulation of ATPase activity uc008cig.1 uc008cig.2 uc008cig.3 uc008cig.4 
ENSMUST00000001566.10 Tubb5 ENSMUST00000001566.10 tubulin, beta 5 class I (from RefSeq NM_011655.5) B1B178 ENSMUST00000001566.1 ENSMUST00000001566.2 ENSMUST00000001566.3 ENSMUST00000001566.4 ENSMUST00000001566.5 ENSMUST00000001566.6 ENSMUST00000001566.7 ENSMUST00000001566.8 ENSMUST00000001566.9 NM_011655 P05218 P99024 Q3TFB6 Q3THH9 Q3TIL1 Q3UAV4 Q3UF52 Q8WUC1 Q9CY33 TBB5_MOUSE uc008ciq.1 uc008ciq.2 uc008ciq.3 uc008ciq.4 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Heterodimer of alpha and beta chains (By similarity). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with CIMAP3 (PubMed:20643351). Interacts with DIAPH1 (By similarity). Interacts with MX1 (By similarity). May interact with RNABP10 (PubMed:18347012). Interacts with CFAP157 (PubMed:27965440). Nascent tubulin polypeptide interacts (via beta-tubulin MREI motif) with TTC5/STRAP; this interaction results in tubulin mRNA-targeted degradation (By similarity). Cytoplasm, cytoskeleton Ubiquitously expressed with highest levels in spleen, thymus and immature brain. Expressed in embryonic brain, including throughout the developing cortex and in the subventricular zone. Also found in radial glial cells, intermediate progenitors, migrating neurons and postmitotic neurons (PubMed:23246003). Expressed in skin and developing hair follicle (PubMed:26637975). The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation. Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility (PubMed:33414192). Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:15890843). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (PubMed:23897886). Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. Results in a perturbation of the cell cycle of neurogenic progenitors as well as an alteration in the position of migrating neurons. There is a decrease in neurons in the cortical plate and an accumulation of cells within the ventricular and intermediate zones. Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle GTPase activity structural constituent of cytoskeleton GTP binding nucleus nuclear envelope lumen cytoplasm cytosol cytoskeleton microtubule microtubule-based process cellular process protein domain specific binding ubiquitin protein ligase binding GTPase activating protein binding macromolecular complex cytoplasmic ribonucleoprotein granule MHC class I protein binding cell body macromolecular complex binding membrane raft tubulin complex regulation of synapse organization spindle assembly uc008ciq.1 uc008ciq.2 uc008ciq.3 uc008ciq.4 
ENSMUST00000001569.15 Flot1 ENSMUST00000001569.15 flotillin 1, transcript variant 15 (from RefSeq NR_176952.1) ENSMUST00000001569.1 ENSMUST00000001569.10 ENSMUST00000001569.11 ENSMUST00000001569.12 ENSMUST00000001569.13 ENSMUST00000001569.14 ENSMUST00000001569.2 ENSMUST00000001569.3 ENSMUST00000001569.4 ENSMUST00000001569.5 ENSMUST00000001569.6 ENSMUST00000001569.7 ENSMUST00000001569.8 ENSMUST00000001569.9 Flot1 NR_176952 Q540I4 Q540I4_MOUSE uc008cip.1 uc008cip.2 uc008cip.3 Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS. Membrane Endosome Belongs to the band 7/mec-2 family. Flotillin subfamily. membrane raft assembly positive regulation of cytokine production uropod positive regulation of protein phosphorylation protease binding regulation of receptor internalization endosome early endosome microtubule organizing center plasma membrane caveola cell-cell junction cell-cell adherens junction COP9 signalosome basolateral plasma membrane flotillin complex extracellular matrix disassembly lamellipodium cortical actin cytoskeleton cytoplasmic vesicle positive regulation of protein binding positive regulation of interferon-beta production dsRNA transport positive regulation of heterotypic cell-cell adhesion positive regulation of toll-like receptor 3 signaling pathway centriolar satellite response to endoplasmic reticulum stress ionotropic glutamate receptor binding cell-cell contact zone plasma membrane raft assembly membrane raft synapse positive regulation of endocytosis protein heterodimerization activity positive regulation of skeletal muscle tissue development presynaptic active zone protein stabilization positive regulation of NF-kappaB transcription factor activity protein homooligomerization regulation of neurotransmitter uptake positive regulation of cell adhesion molecule production protein kinase C signaling cellular response to exogenous dsRNA protein localization to plasma membrane presynapse glutamatergic synapse GABA-ergic synapse positive regulation of myoblast fusion positive regulation of cell junction assembly protein localization to membrane raft positive regulation of cell-cell adhesion mediated by cadherin uc008cip.1 uc008cip.2 uc008cip.3 
ENSMUST00000001583.8 Ell2 ENSMUST00000001583.8 elongation factor for RNA polymerase II 2 (from RefSeq NM_138953.2) E9QPE1 ELL2_MOUSE ENSMUST00000001583.1 ENSMUST00000001583.2 ENSMUST00000001583.3 ENSMUST00000001583.4 ENSMUST00000001583.5 ENSMUST00000001583.6 ENSMUST00000001583.7 NM_138953 Q3UKU1 uc007rfu.1 uc007rfu.2 uc007rfu.3 uc007rfu.4 Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (By similarity). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with AFF4; the interaction is direct and leads to stabilize ELL2 and prevent ELL2 ubiquitination. Interacts with EAF1 and EAF2 (By similarity). Nucleus Ubiquitinated by SIAH1, leading to its degradation by the proteasome. Interaction with AFF4 stabilizes ELL2 and prevents ELL2 ubiquitination (By similarity). Belongs to the ELL/occludin family. nucleus nucleoplasm transcription elongation from RNA polymerase II promoter transcription elongation factor complex positive regulation of transcription elongation from RNA polymerase II promoter snRNA transcription from RNA polymerase II promoter uc007rfu.1 uc007rfu.2 uc007rfu.3 uc007rfu.4 
ENSMUST00000001592.15 Jup ENSMUST00000001592.15 junction plakoglobin (from RefSeq NM_010593.2) ENSMUST00000001592.1 ENSMUST00000001592.10 ENSMUST00000001592.11 ENSMUST00000001592.12 ENSMUST00000001592.13 ENSMUST00000001592.14 ENSMUST00000001592.2 ENSMUST00000001592.3 ENSMUST00000001592.4 ENSMUST00000001592.5 ENSMUST00000001592.6 ENSMUST00000001592.7 ENSMUST00000001592.8 ENSMUST00000001592.9 Jup NM_010593 PLAK_MOUSE Q02257 Q8CGD3 uc007lkz.1 uc007lkz.2 uc007lkz.3 uc007lkz.4 Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2 (By similarity). Cell junction, adherens junction Cell junction, desmosome Cytoplasm, cytoskeleton Membrane ; Peripheral membrane protein Note=Cytoplasmic in a soluble and membrane-associated form. The entire ARM repeats region mediates binding to CDH1/E- cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region (By similarity). May be phosphorylated by FER. Belongs to the beta-catenin family. positive regulation of cell-matrix adhesion desmosome assembly transcription coactivator activity structural molecule activity protein binding nucleus cytoplasm cytosol cytoskeleton intermediate filament plasma membrane cell-cell junction adherens junction cell-cell adherens junction fascia adherens cell adhesion cytoplasmic side of plasma membrane intercalated disc actin cytoskeleton membrane apicolateral plasma membrane lateral plasma membrane catenin complex cell migration protein kinase binding protein phosphatase binding Z disc cell junction desmosome protein-DNA complex nuclear hormone receptor binding regulation of cell proliferation positive regulation of protein import into nucleus negative regulation of blood vessel endothelial cell migration skin development alpha-catenin binding cadherin binding positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter cell adhesion molecule binding detection of mechanical stimulus positive regulation of sequence-specific DNA binding transcription factor activity protein heterooligomerization gamma-catenin-TCF7L2 complex cellular response to indole-3-methanol protein localization to plasma membrane bundle of His cell-Purkinje myocyte adhesion involved in cell communication regulation of heart rate by cardiac conduction cell-cell adhesion regulation of ventricular cardiac muscle cell action potential uc007lkz.1 uc007lkz.2 uc007lkz.3 uc007lkz.4 
ENSMUST00000001595.10 Fkbp10 ENSMUST00000001595.10 FK506 binding protein 10, transcript variant 1 (from RefSeq NM_010221.2) A2A4I0 ENSMUST00000001595.1 ENSMUST00000001595.2 ENSMUST00000001595.3 ENSMUST00000001595.4 ENSMUST00000001595.5 ENSMUST00000001595.6 ENSMUST00000001595.7 ENSMUST00000001595.8 ENSMUST00000001595.9 FKB10_MOUSE Fkbp-rs Fkbp1-rs Fkbp6 Fkbp65 Fkbprp NM_010221 Q61576 Q8VHI1 uc007llb.1 uc007llb.2 uc007llb.3 uc007llb.4 PPIases accelerate the folding of proteins during protein synthesis. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Inhibited by both FK506 and rapamycin, but not by cyclosporin A. Endoplasmic reticulum lumen Expressed in aorta, brain, heart, kidney, lung, spleen and testis (PubMed:7493967, PubMed:11071917). Not detected in liver (PubMed:7493967). Expressed in 12-day-old mouse; no or barely detectable expression is found in adult tissues. N-glycosylated. Phosphorylated. protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity calcium ion binding protein binding FK506 binding endoplasmic reticulum endoplasmic reticulum lumen cytosol membrane isomerase activity peptidyl-proline modification metal ion binding uc007llb.1 uc007llb.2 uc007llb.3 uc007llb.4 
ENSMUST00000001599.4 Klhl10 ENSMUST00000001599.4 kelch-like 10, transcript variant 1 (from RefSeq NM_025727.4) ENSMUST00000001599.1 ENSMUST00000001599.2 ENSMUST00000001599.3 KLH10_MOUSE NM_025727 Q8BVM3 Q9D5V2 Q9DA07 uc007lli.1 uc007lli.2 uc007lli.3 May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. Required for male fertility. Protein modification; protein ubiquitination. Self-associates (By similarity). Interacts with CUL3; indicative for the participation in an E3 ubiquitin ligase complex. Cytoplasm Testis specific. Expressed in elongating and elongated spermatids (steps 9-16). Heterozygous males are completely infertile because of disrupted spermiogenesis characterized by asynchronous spermatid maturation, degeneration of late spermatids, sloughing of postmeiotic germ cells from the seminiferous epithelium, and marked reduction in the numbers of late spermatids. Does not seem to associate with actin. cell morphogenesis protein binding cytoplasm spermatogenesis spermatid development male gonad development fertilization protein ubiquitination cell differentiation male genitalia morphogenesis homeostasis of number of cells within a tissue uc007lli.1 uc007lli.2 uc007lli.3 
ENSMUST00000001611.11 Nom1 ENSMUST00000001611.11 nucleolar protein with MIF4G domain 1, transcript variant 3 (from RefSeq NR_153386.1) E9QPB9 ENSMUST00000001611.1 ENSMUST00000001611.10 ENSMUST00000001611.2 ENSMUST00000001611.3 ENSMUST00000001611.4 ENSMUST00000001611.5 ENSMUST00000001611.6 ENSMUST00000001611.7 ENSMUST00000001611.8 ENSMUST00000001611.9 Gm1040 NOM1_MOUSE NR_153386 Q3UFM5 uc008wuj.1 uc008wuj.2 uc008wuj.3 Plays a role in targeting PPP1CA to the nucleolus. May interact with EIF4A1, EIF4A2 and EIF4A3. Interacts with PPP1CA and PPP1CC (By similarity). Nucleus, nucleolus Belongs to the CWC22 family. RNA binding nucleus nucleolus ribosomal small subunit biogenesis hair follicle maturation uc008wuj.1 uc008wuj.2 uc008wuj.3 
ENSMUST00000001620.13 Fxr1 ENSMUST00000001620.13 FMR1 autosomal homolog 1, transcript variant 1 (from RefSeq NM_001113188.2) ENSMUST00000001620.1 ENSMUST00000001620.10 ENSMUST00000001620.11 ENSMUST00000001620.12 ENSMUST00000001620.2 ENSMUST00000001620.3 ENSMUST00000001620.4 ENSMUST00000001620.5 ENSMUST00000001620.6 ENSMUST00000001620.7 ENSMUST00000001620.8 ENSMUST00000001620.9 FXR1_MOUSE Fxr1 Fxr1h NM_001113188 Q61584 Q8VCU4 Q9R1E2 Q9R1E3 Q9R1E4 Q9R1E5 Q9WUA7 Q9WUA8 Q9WUA9 uc008oxn.1 uc008oxn.2 uc008oxn.3 uc008oxn.4 uc008oxn.5 mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:15128702, PubMed:25456134, PubMed:32328638, PubMed:35951695). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:25456134). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:32328638, PubMed:35951695). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (PubMed:35951695). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (By similarity). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro- inflammatory transcripts (By similarity). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (PubMed:15548538). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (PubMed:25456134). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (PubMed:28204491). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (PubMed:32893934). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:15128702, PubMed:32328638). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (By similarity). Interacts with FMR1 (By similarity). Interacts with FRX2 (By similarity). Interacts with TDRD3 (By similarity). Interacts with HABP4 (By similarity). Interacts with CYFIP2 but not with CYFIP1 (PubMed:11438699). Interacts with EIF4G3; promoting translation of target mRNAs (PubMed:35951695). Interacts with ELAVL1 (By similarity). Interacts with CEP63; inhibiting 'Lys-63'-linked ubiquitination (By similarity). Cytoplasm, Cytoplasmic ribonucleoprotein granule Cytoplasm, Stress granule Cytoplasm Cell projection, dendrite Cell projection, dendritic spine Cell projection, axon Nucleus envelope Postsynapse Note=Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments (PubMed:35951695). Localizes to stress granules following phosphorylation at Ser-449 by PAK1 (By similarity). Adjacent to Z-lines in muscles (PubMed:30770808). Event=Alternative splicing; Named isoforms=7; Name=E; IsoId=Q61584-1; Sequence=Displayed; Name=A; IsoId=Q61584-2; Sequence=VSP_002836, VSP_002838, VSP_002840; Name=B; IsoId=Q61584-3; Sequence=VSP_002838; Name=C; IsoId=Q61584-4; Sequence=VSP_002839; Name=D; IsoId=Q61584-5; Sequence=VSP_002836, VSP_002839; Name=F; IsoId=Q61584-6; Sequence=VSP_002836; Name=G; IsoId=Q61584-7; Sequence=VSP_002837; In early embryogenesis, highest expression in somites and central nervous system (PubMed:10409431, PubMed:16000371). Also expressed in spinal cord, surrounding mesenchymal tissue and undifferentiated gonad (PubMed:10409431). In mid-embryogenesis, most prominent in gonad and muscle tissue (PubMed:10409431). Also expressed in liver, retina, telencephalon and mesencephalon (PubMed:10409431). In late embryogenesis, restricted to skeletal muscle and proliferative active layers of brain (PubMed:10409431). After birth, highly expressed in postmeiotic spermatids (at protein level) (PubMed:10409431, PubMed:35951695). Expressed in neurons of the developing hippocampus (PubMed:22022532). Expressed in new cells generated in the adult dentate gyrus throughout the progression of adult neurogenesis (PubMed:28204491). Intermediate levels are found in heart, liver and kidney with lower levels in brain and skeletal muscle (PubMed:10409431). Isoform(s) containing the 27 amino acid pocket (residues 564-590) are present in adult heart and muscle (PubMed:10409431, PubMed:32328638). [Isoform A]: Present in adult heart and muscle. [Isoform B]: Present in adult heart and muscle. [Isoform E]: Present in adult heart and muscle. [Isoform F]: Present in adult heart and muscle. [Isoform G]: Present in adult heart and muscle. Disordered region at the C-terminus undergoes liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that stores mRNAs. The tandem Agenet-like domains preferentially recognize trimethylated histone peptides. Phosphorylation at Ser-449 by PAK1 promotes its relocalization to stress granules and activity (By similarity). Phosphorylated by MAPK1/ERK2, promoting subsequent phosphorylation by GSK3B (PubMed:26240334). Phosphorylated by GSK3B, promoting ubiquitination and degradation by the proteasome (PubMed:26240334, PubMed:29142209, PubMed:32893934). Ubiquitinated by the SCF(FBXO4) complex, leading to its degradation by the proteasome: ubiquitination by the SCF(FBXO4) complex takes place following phosphorylation by GSK3B (PubMed:29142209, PubMed:32893934, PubMed:26240334). Ubiquitinated and degraded in a GSK3B-dependent manner in during both scaling and sleep deprivation (PubMed:32893934). Ubiquitinated via 'Lys-63'-linked ubiquitin, leading to its degradation: interaction with CEP63 inhibits 'Lys-63'-linked ubiquitination (By similarity). Death shortly after birth (PubMed:15128702). Mice expressing low levels of Fxr1 show postnatal growth retardation with reduced increase in muscle mass and strength (PubMed:15128702). They die within 3 weeks of birth (PubMed:15128702). Conditional deletion in macrophages leads to enhanced Tumor necrosis factor (TNF) production (PubMed:15548538). Conditional deletion in excitatory neurons in the forebrain of early postnatal mice enhances long-term storage of spatial memories, hippocampal late-phase long-term potentiation: defects are caused by de novo GRIA2/GluA2 synthesis (PubMed:25456134). Conditional deletion in adult neural stem cells results in fewer adult-born cells in the dentate gyrus, reducing populations across different stages of neurogenesis, including radial glia-like cells, intermediate progenitors, neuroblasts, immature neurons and neurons (PubMed:28204491). Conditional deletion in germline cells leads to male infertility: defects are caused by impaired translation of a subset of transcripts in adult mouse testes (PubMed:35951695). Belongs to the FMR1 family. regulation of alternative mRNA splicing, via spliceosome positive regulation of protein phosphorylation G-quadruplex RNA binding nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding nucleus cytoplasm cytosol polysome regulation of translation multicellular organism development muscle organ development postsynaptic density negative regulation of translation cell differentiation axon dendrite growth cone RNA strand annealing activity ribonucleoprotein granule cytoplasmic ribonucleoprotein granule protein homodimerization activity neuronal cell body costamere dendritic spine regulation of mRNA stability dendritic spine neck translation regulator activity positive regulation of translation protein heterodimerization activity perinuclear region of cytoplasm regulation of filopodium assembly presynapse postsynapse glutamatergic synapse dendritic filopodium positive regulation of gene silencing by miRNA positive regulation of response to DNA damage stimulus uc008oxn.1 uc008oxn.2 uc008oxn.3 uc008oxn.4 uc008oxn.5 
ENSMUST00000001631.7 Acap1 ENSMUST00000001631.7 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 (from RefSeq NM_153788.3) ACAP1_MOUSE Centb1 ENSMUST00000001631.1 ENSMUST00000001631.2 ENSMUST00000001631.3 ENSMUST00000001631.4 ENSMUST00000001631.5 ENSMUST00000001631.6 Kiaa0050 NM_153788 Q3U441 Q571H6 Q8K2H4 uc007jsg.1 uc007jsg.2 GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity). GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid. Banana-shaped homodimer laterally assembling into tetramers, the tetramers further pack helically onto the membrane. Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP- bound ARF6 and GULP1. Interacts with ITGB1; required for ITGB1 recycling. Recycling endosome membrane ; Peripheral membrane protein ; Cytoplasmic side PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes. Only one PH domain of one ACAP1 dimer inserts into the membrane, while the other PH domain acts primaryly to interact with adjacent ACAP1 dimers (By similarity). The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions (By similarity). Cells overexpressing Acap1 show accumulation of an electron dense coat containing Acap1 and Cltc on internal membranes as well as accumulation of Tfrc in pericentriolar recycling endosomes. Adipocytes with reduced level of Acap1 or Cltc fail to transport SLC2A4/GLUT4 from recycling endosomes to the cell surface upon insulin stimulation. molecular_function GTPase activator activity endosome lipid metabolic process signal transduction biological_process membrane lipid catabolic process hydrolase activity positive regulation of GTPase activity metal ion binding recycling endosome membrane uc007jsg.1 uc007jsg.2 
ENSMUST00000001652.7 Bdkrb2 ENSMUST00000001652.7 bradykinin receptor, beta 2 (from RefSeq NM_009747.2) B9EHE3 BKRB2_MOUSE ENSMUST00000001652.1 ENSMUST00000001652.2 ENSMUST00000001652.3 ENSMUST00000001652.4 ENSMUST00000001652.5 ENSMUST00000001652.6 NM_009747 P32299 uc007oym.1 uc007oym.2 uc007oym.3 Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1 (By similarity). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P32299-1; Sequence=Displayed; Name=Short; IsoId=P32299-2; Sequence=VSP_001866; Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily. protease binding acute inflammatory response to antigenic stimulus G-protein coupled receptor activity bradykinin receptor activity endosome plasma membrane smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration negative regulation of cell proliferation response to salt stress membrane integral component of membrane beta-2 adrenergic receptor binding type 1 angiotensin receptor binding negative regulation of peptidyl-serine phosphorylation maintenance of permeability of blood-brain barrier vasoconstriction vasodilation negative regulation of blood pressure protein heterodimerization activity arachidonic acid secretion negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator uc007oym.1 uc007oym.2 uc007oym.3 
ENSMUST00000001667.13 Csn3 ENSMUST00000001667.13 casein kappa, transcript variant 3 (from RefSeq NM_001356571.1) CASK_MOUSE Csn10 Csnk ENSMUST00000001667.1 ENSMUST00000001667.10 ENSMUST00000001667.11 ENSMUST00000001667.12 ENSMUST00000001667.2 ENSMUST00000001667.3 ENSMUST00000001667.4 ENSMUST00000001667.5 ENSMUST00000001667.6 ENSMUST00000001667.7 ENSMUST00000001667.8 ENSMUST00000001667.9 NM_001356571 P06796 Q9D1U2 uc008xzi.1 uc008xzi.2 uc008xzi.3 Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk. Secreted. Mammary gland specific. Secreted in milk. Belongs to the kappa-casein family. molecular_function extracellular region extracellular space lactation protein stabilization uc008xzi.1 uc008xzi.2 uc008xzi.3 
ENSMUST00000001672.12 Ifrd1 ENSMUST00000001672.12 interferon-related developmental regulator 1, transcript variant 6 (from RefSeq NR_181996.1) ENSMUST00000001672.1 ENSMUST00000001672.10 ENSMUST00000001672.11 ENSMUST00000001672.2 ENSMUST00000001672.3 ENSMUST00000001672.4 ENSMUST00000001672.5 ENSMUST00000001672.6 ENSMUST00000001672.7 ENSMUST00000001672.8 ENSMUST00000001672.9 IFRD1_MOUSE NR_181996 P19182 P21835 P70228 Q80XM4 Tis7 uc007nky.1 uc007nky.2 uc007nky.3 uc007nky.4 Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal. Interacts with PSIP1/LEDGF. By mitogens such as TPA in 373 cells and by nerve growth factor in PC12 pheochromocytoma cells. Belongs to the IFRD family. Was originally thought to be interferon beta-2. nucleus cytoplasm multicellular organism development striated muscle tissue development cell differentiation negative regulation of axon extension muscle cell differentiation skeletal muscle tissue regeneration positive regulation of transcription from RNA polymerase II promoter negative regulation of collateral sprouting positive regulation of sequence-specific DNA binding transcription factor activity RNA polymerase II sequence-specific DNA binding transcription factor binding uc007nky.1 uc007nky.2 uc007nky.3 uc007nky.4 
ENSMUST00000001675.14 Stk38l ENSMUST00000001675.14 serine/threonine kinase 38 like, transcript variant 1 (from RefSeq NM_172734.3) B2KFR4 ENSMUST00000001675.1 ENSMUST00000001675.10 ENSMUST00000001675.11 ENSMUST00000001675.12 ENSMUST00000001675.13 ENSMUST00000001675.2 ENSMUST00000001675.3 ENSMUST00000001675.4 ENSMUST00000001675.5 ENSMUST00000001675.6 ENSMUST00000001675.7 ENSMUST00000001675.8 ENSMUST00000001675.9 NM_172734 Ndr2 Q6P6K6 Q7TSE6 Q8BWK4 ST38L_MOUSE Stk38l uc009esh.1 uc009esh.2 uc009esh.3 uc009esh.4 Involved in the regulation of structural processes in differentiating and mature neuronal cells. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium- dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2 to the N-terminal of STK38L (By similarity). Homodimeric S100B binds two molecules of STK38L. Interacts with MOB1 and MOB2 (By similarity). Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4. Cytoplasm Cytoplasm, cytoskeleton Membrane Note=Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TSE6-1; Sequence=Displayed; Name=2; IsoId=Q7TSE6-2; Sequence=VSP_012334; Highly expressed in the large and small intestine, stomach and testis. High levels also present in the brain, in particular the neurocortex, basal forebrain, hippocampus, the amygdala, cerebellum and brainstem. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. nucleotide binding magnesium ion binding actin binding protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm cytosol cytoskeleton protein phosphorylation actin cytoskeleton membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction metal ion binding regulation of cellular component organization uc009esh.1 uc009esh.2 uc009esh.3 uc009esh.4 
ENSMUST00000001699.8 Hoxc10 ENSMUST00000001699.8 homeobox C10 (from RefSeq NM_010462.5) ENSMUST00000001699.1 ENSMUST00000001699.2 ENSMUST00000001699.3 ENSMUST00000001699.4 ENSMUST00000001699.5 ENSMUST00000001699.6 ENSMUST00000001699.7 HXC10_MOUSE Hox-3.6 Hoxc-10 NM_010462 P31257 P31312 Q7TMT7 uc007xwz.1 uc007xwz.2 uc007xwz.3 uc007xwz.4 uc007xwz.5 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus. Belongs to the Abd-B homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification proximal/distal pattern formation nuclear body spinal cord motor neuron cell fate specification embryonic limb morphogenesis sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter neuromuscular process uc007xwz.1 uc007xwz.2 uc007xwz.3 uc007xwz.4 uc007xwz.5 
ENSMUST00000001700.7 Hoxc13 ENSMUST00000001700.7 homeobox C13 (from RefSeq NM_010464.2) ENSMUST00000001700.1 ENSMUST00000001700.2 ENSMUST00000001700.3 ENSMUST00000001700.4 ENSMUST00000001700.5 ENSMUST00000001700.6 HXC13_MOUSE Hoxc-13 NM_010464 P50207 Q53Z78 Q920I7 uc007xwv.1 uc007xwv.2 uc007xwv.3 Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair- specific genes. Nucleus. Expressed in differentiating keratinocytes. In the hair follicle lower matrix, expressed in all 3 hair shaft-forming compartments, i.e. cuticle, cortex and medulla. Expression stops sharply at the boundary with the germinal matrix compartment. Belongs to the Abd-B homeobox family. transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding hair follicle development DNA binding chromatin binding nucleus regulation of transcription, DNA-templated multicellular organism development anatomical structure morphogenesis anterior/posterior pattern specification nail development sequence-specific DNA binding tongue morphogenesis positive regulation of transcription from RNA polymerase II promoter uc007xwv.1 uc007xwv.2 uc007xwv.3 
ENSMUST00000001701.4 Hoxc11 ENSMUST00000001701.4 homeobox C11 (from RefSeq NM_001024842.1) B9EI74 ENSMUST00000001701.1 ENSMUST00000001701.2 ENSMUST00000001701.3 HXC11_MOUSE Hox-3.7 Hoxc-11 NM_001024842 P31313 uc007xwy.1 uc007xwy.2 uc007xwy.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus. Belongs to the Abd-B homeobox family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development metanephros development organ induction DNA binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification proximal/distal pattern formation embryonic digit morphogenesis sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter embryonic skeletal joint morphogenesis uc007xwy.1 uc007xwy.2 uc007xwy.3 
ENSMUST00000001703.8 Hoxc8 ENSMUST00000001703.8 homeobox C8 (from RefSeq NM_010466.2) ENSMUST00000001703.1 ENSMUST00000001703.2 ENSMUST00000001703.3 ENSMUST00000001703.4 ENSMUST00000001703.5 ENSMUST00000001703.6 ENSMUST00000001703.7 HXC8_MOUSE Hox-3.1 Hoxc-8 NM_010466 P09025 uc012aaf.1 uc012aaf.2 uc012aaf.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Interacts with HOMEZ (By similarity). Forms a DNA-binding heterodimer with transcription factor PBX1 (PubMed:7791786). Nucleus. Initially found in all tissues of the posterior region in 8.5 and 9.5 dpc. Embryos, it eventually become specifically located in neural tissue. Belongs to the Antp homeobox family. negative regulation of transcription from RNA polymerase II promoter DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification microtubule cytoskeleton neuron differentiation sequence-specific DNA binding skeletal system morphogenesis uc012aaf.1 uc012aaf.2 uc012aaf.3 
ENSMUST00000001706.7 Hoxc9 ENSMUST00000001706.7 homeobox C9 (from RefSeq NM_008272.3) ENSMUST00000001706.1 ENSMUST00000001706.2 ENSMUST00000001706.3 ENSMUST00000001706.4 ENSMUST00000001706.5 ENSMUST00000001706.6 HXC9_MOUSE Hox-3.2 Hoxc-9 NM_008272 P09633 uc007xxa.1 uc007xxa.2 uc007xxa.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Interacts with Geminin/GMNN, which inhibits transcriptional activity. Nucleus. Belongs to the Abd-B homeobox family. DNA binding nucleus nucleoplasm transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification aggresome sequence-specific DNA binding embryonic skeletal system morphogenesis embryonic skeletal system development uc007xxa.1 uc007xxa.2 uc007xxa.3 
ENSMUST00000001709.3 Hoxc5 ENSMUST00000001709.3 homeobox C5 (from RefSeq NM_175730.5) ENSMUST00000001709.1 ENSMUST00000001709.2 HXC5_MOUSE Hox-3.4 Hoxc-5 NM_175730 P32043 Q8BJW4 uc007xxe.1 uc007xxe.2 uc007xxe.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus. Belongs to the Antp homeobox family. RNA polymerase II distal enhancer sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification cell junction sequence-specific DNA binding embryonic skeletal system development uc007xxe.1 uc007xxe.2 uc007xxe.3 
ENSMUST00000001711.6 Hoxc6 ENSMUST00000001711.6 homeobox C6 (from RefSeq NM_010465.2) ENSMUST00000001711.1 ENSMUST00000001711.2 ENSMUST00000001711.3 ENSMUST00000001711.4 ENSMUST00000001711.5 HXC6_MOUSE Hox-3.3 Hoxc-6 NM_010465 P10629 Q61683 uc007xxd.1 uc007xxd.2 uc007xxd.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus. Event=Alternative splicing; Named isoforms=2; Name=PRII; IsoId=P10629-1; Sequence=Displayed; Name=PRI; IsoId=P10629-2; Sequence=VSP_002393; Belongs to the Antp homeobox family. RNA polymerase II distal enhancer sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification sequence-specific DNA binding embryonic skeletal system development uc007xxd.1 uc007xxd.2 uc007xxd.3 
ENSMUST00000001712.8 Cabin1 ENSMUST00000001712.8 calcineurin binding protein 1 (from RefSeq NM_172549.3) Cabin1 ENSMUST00000001712.1 ENSMUST00000001712.2 ENSMUST00000001712.3 ENSMUST00000001712.4 ENSMUST00000001712.5 ENSMUST00000001712.6 ENSMUST00000001712.7 G3X8Q1 G3X8Q1_MOUSE NM_172549 uc007fqx.1 uc007fqx.2 uc007fqx.3 Nucleus protein phosphatase inhibitor activity nucleus nucleoplasm cytosol DNA replication-independent nucleosome assembly signal transduction aggresome protein domain specific binding protein phosphatase 2B binding negative regulation of phosphoprotein phosphatase activity negative regulation of cell death nucleosome binding uc007fqx.1 uc007fqx.2 uc007fqx.3 
ENSMUST00000001713.10 Gstt1 ENSMUST00000001713.10 glutathione S-transferase, theta 1, transcript variant 1 (from RefSeq NM_008185.3) ENSMUST00000001713.1 ENSMUST00000001713.2 ENSMUST00000001713.3 ENSMUST00000001713.4 ENSMUST00000001713.5 ENSMUST00000001713.6 ENSMUST00000001713.7 ENSMUST00000001713.8 ENSMUST00000001713.9 GSTT1_MOUSE NM_008185 Q64471 Q91X50 uc007frc.1 uc007frc.2 uc007frc.3 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Homodimer. Cytoplasm. Nucleus. In liver, highest expression found in central vein limiting plate hepatocytes. Also expressed in interlobular bile duct epithelial cells. In lung, expressed in club cells and ciliated cells of the bronchiolar epithelium and in type II alveolar cells of the lung parenchyma. Belongs to the GST superfamily. Theta family. glutathione transferase activity glutathione peroxidase activity nucleus cytoplasm cytosol DNA modification glutathione metabolic process response to salicylic acid response to selenium ion response to organic cyclic compound transferase activity dichloromethane metabolic process response to vitamin E response to drug alkylhalidase activity cellular oxidant detoxification uc007frc.1 uc007frc.2 uc007frc.3 
ENSMUST00000001715.10 Gstt3 ENSMUST00000001715.10 glutathione S-transferase, theta 3, transcript variant 1 (from RefSeq NM_133994.3) ENSMUST00000001715.1 ENSMUST00000001715.2 ENSMUST00000001715.3 ENSMUST00000001715.4 ENSMUST00000001715.5 ENSMUST00000001715.6 ENSMUST00000001715.7 ENSMUST00000001715.8 ENSMUST00000001715.9 GSTT3_MOUSE Gstt3 NM_133994 Q6P6I4 Q99L20 uc007frb.1 uc007frb.2 uc007frb.3 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows high activity towards 4-nitrobenzyl chloride (4-NBC). Also has lower activity towards 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP), cumene hydroperoxide, 1- chloro-2,4-dinitrobenzene (CDNB), 7-chloro-4-nitrobenzo-2-oxa-1,3- diazole (NBD-Cl), and ethacrynic acid. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Homodimer. Cytoplasm Expressed strongly in liver, and at lower levels in kidney and testis. Belongs to the GST superfamily. Theta family. glutathione transferase activity cytoplasm glutathione metabolic process transferase activity uc007frb.1 uc007frb.2 uc007frb.3 
ENSMUST00000001716.8 Ddt ENSMUST00000001716.8 D-dopachrome tautomerase (from RefSeq NM_010027.1) Ddt ENSMUST00000001716.1 ENSMUST00000001716.2 ENSMUST00000001716.3 ENSMUST00000001716.4 ENSMUST00000001716.5 ENSMUST00000001716.6 ENSMUST00000001716.7 NM_010027 Q3UNI8 Q3UNI8_MOUSE uc007fra.1 uc007fra.2 uc007fra.3 Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Homotrimer. Belongs to the MIF family. uc007fra.1 uc007fra.2 uc007fra.3 
ENSMUST00000001720.14 Tat ENSMUST00000001720.14 tyrosine aminotransferase (from RefSeq NM_146214.3) ATTY_MOUSE ENSMUST00000001720.1 ENSMUST00000001720.10 ENSMUST00000001720.11 ENSMUST00000001720.12 ENSMUST00000001720.13 ENSMUST00000001720.2 ENSMUST00000001720.3 ENSMUST00000001720.4 ENSMUST00000001720.5 ENSMUST00000001720.6 ENSMUST00000001720.7 ENSMUST00000001720.8 ENSMUST00000001720.9 NM_146214 Q3UER7 Q8BTI1 Q8QZR1 uc009njs.1 uc009njs.2 uc009njs.3 uc009njs.4 This gene encodes a liver-specific mitochondrial enzyme that catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Regulated by glucocorticoid and polypeptide hormones, this gene's expression is affected by deletion of a regulatory region near the albino locus on chromosome 7. Mutations in this gene cause tyrosinemia type II in humans. [provided by RefSeq, Mar 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149383.1, BC030728.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine. Reaction=2-oxoglutarate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L- glutamate; Xref=Rhea:RHEA:15093, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:36242, ChEBI:CHEBI:58315; EC=2.6.1.5; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Kinetic parameters: KM=1.8 mM for tyrosine ; KM=4.9 mM for glutamate ; KM=11.4 mM for phenylalanine ; KM=1.8 mM for 2-oxoglutarate ; KM=0.7 mM for p-hydroxyphenylpyruvate ; pH dependence: Optimum pH is 7. ; Temperature dependence: Optimum temperature is 55-70 degrees Celsius. ; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6. Homodimer. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. catalytic activity L-tyrosine:2-oxoglutarate aminotransferase activity mitochondrion 2-oxoglutarate metabolic process cellular amino acid metabolic process glutamate metabolic process L-phenylalanine catabolic process tyrosine catabolic process response to oxidative stress transaminase activity biosynthetic process aromatic amino acid family metabolic process aromatic amino acid family catabolic process response to organic cyclic compound amino acid binding transferase activity pyridoxal phosphate binding response to mercury ion response to glucocorticoid uc009njs.1 uc009njs.2 uc009njs.3 uc009njs.4 
ENSMUST00000001724.12 Ddx18 ENSMUST00000001724.12 DEAD box helicase 18 (from RefSeq NM_025860.3) DDX18_MOUSE ENSMUST00000001724.1 ENSMUST00000001724.10 ENSMUST00000001724.11 ENSMUST00000001724.2 ENSMUST00000001724.3 ENSMUST00000001724.4 ENSMUST00000001724.5 ENSMUST00000001724.6 ENSMUST00000001724.7 ENSMUST00000001724.8 ENSMUST00000001724.9 NM_025860 Q3MIB0 Q8BVZ2 Q8K363 Q9D2E0 uc007cjw.1 uc007cjw.2 uc007cjw.3 uc007cjw.4 Probable RNA-dependent helicase. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Interacts with NOL8; the interaction is RNA-dependent. Nucleus, nucleolus Chromosome Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. nucleotide binding maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus chromosome nucleolus hydrolase activity cellular response to estradiol stimulus uc007cjw.1 uc007cjw.2 uc007cjw.3 uc007cjw.4 
ENSMUST00000001757.9 Eef1e1 ENSMUST00000001757.9 eukaryotic translation elongation factor 1 epsilon 1 (from RefSeq NM_025380.2) ENSMUST00000001757.1 ENSMUST00000001757.2 ENSMUST00000001757.3 ENSMUST00000001757.4 ENSMUST00000001757.5 ENSMUST00000001757.6 ENSMUST00000001757.7 ENSMUST00000001757.8 MCA3_MOUSE NM_025380 Q9D1M4 uc007qdw.1 uc007qdw.2 uc007qdw.3 Positive modulator of ATM response to DNA damage. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:12060739). Can interact simultaneously with MARS1 and EPRS1. Forms a linear complex that contains MARS1, EEF1E1, EPRS1 and AIMP2 that is at the core of the multisubunit complex. Interacts with ATM and ATR. The interaction with ATM, which takes place independently of TP53, is induced by DNA damage that may occur during genotoxic stress or cell growth. The interaction with ATR is enhanced by UV irradiation (By similarity). Cytoplasm Nucleus Note=Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes at S phase and following DNA damage. By DNA damaging agents, such as UV, adriamycin, actinomycin D and cisplatin. protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol translation negative regulation of cell proliferation aminoacyl-tRNA synthetase multienzyme complex positive regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator cellular response to leukemia inhibitory factor positive regulation of cellular senescence positive regulation of apoptotic signaling pathway uc007qdw.1 uc007qdw.2 uc007qdw.3 
ENSMUST00000001780.10 Akt1 ENSMUST00000001780.10 thymoma viral proto-oncogene 1, transcript variant 11 (from RefSeq NR_176844.1) AKT1_MOUSE Akt ENSMUST00000001780.1 ENSMUST00000001780.2 ENSMUST00000001780.3 ENSMUST00000001780.4 ENSMUST00000001780.5 ENSMUST00000001780.6 ENSMUST00000001780.7 ENSMUST00000001780.8 ENSMUST00000001780.9 NR_176844 P31750 Q62274 Q6GSA6 Rac uc007pex.1 uc007pex.2 uc007pex.3 AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:11882383, PubMed:21620960, PubMed:21432781, PubMed:26095253, PubMed:26107252, PubMed:32350463). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:11882383, PubMed:21620960, PubMed:21432781). AKT is responsible of the regulation of glucose uptake by mediating insulin- induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (PubMed:9415393). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (PubMed:11579209). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (PubMed:11994271). AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity (PubMed:22057101). Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (PubMed:22057101). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating the mTORC1 signaling pathway, and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Also regulates the mTORC1 signaling pathway by catalyzing phosphorylation of CASTOR1 and DEPDC5. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF- kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (By similarity). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (PubMed:10454575). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase- activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (PubMed:19778506). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) (PubMed:11282895, PubMed:18288188). AKT mediates the antiapoptotic effects of IGF-I (PubMed:11282895). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (By similarity). May be involved in the regulation of the placental development (PubMed:12783884). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro- apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53. Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility. Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation. Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (By similarity). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (By similarity). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (PubMed:32228865). Acts as a negative regulator of the cGAS-STING pathway by mediating phosphorylation of CGAS during mitosis, leading to its inhibition (PubMed:26440888). Acts as an inhibitor of tRNA methylation by mediating phosphorylation of the N-terminus of METTL1, thereby inhibiting METTL1 methyltransferase activity (By similarity). In response to LPAR1 receptor pathway activation, phosphorylates Rabin8/RAB3IP which alters its activity and phosphorylates WDR44 which induces WDR44 binding to Rab11, thereby switching Rab11 vesicular function from preciliary trafficking to endocytic recycling (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Three specific sites, one in the kinase domain (Thr-308) and the two other ones in the C-terminal regulatory region (Ser-473 and Tyr-474), need to be phosphorylated for its full activation. Interacts with and phosphorylated by PDPK1 (By similarity). Interacts with AGAP2 (isoform 2/PIKE-A); the interaction occurs in the presence of guanine nucleotides. Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A and TCL1B. Interacts with CDKN1B; the interaction phosphorylates CDKN1B promoting 14-3-3 binding and cell- cycle progression. Interacts with MAP3K5 and TRAF6. Interacts with BAD, PPP2R5B, STK3 and STK4. Interacts (via PH domain) with SIRT1. Interacts with SRPK2 in a phosphorylation-dependent manner. Interacts with TRIM13; the interaction ubiquitinates AKT1 leading to its proteasomal degradation. Interacts with RAF1 (By similarity). Interacts (via the C- terminus) with CCDC88A (via its C-terminus) and THEM4 (via its C- terminus). Interacts with GRB10; the interaction leads to GRB10 phosphorylation thus promoting YWHAE-binding. Interacts with KCTD20 (PubMed:24156551). Interacts with BTBD10 (PubMed:18160256). Interacts with PA2G4 (By similarity). Interacts with KIF14; the interaction is detected in the plasma membrane upon INS stimulation and promotes AKT1 phosphorylation (By similarity). Interacts with FAM83B; activates the PI3K/AKT signaling cascade (By similarity). Interacts with WDFY2 (via WD repeats 1-3) (PubMed:16792529, PubMed:20189988). Forms a complex with WDFY2 and FOXO1 (PubMed:18388859). Interacts with FAM168A (By similarity). Interacts with SYAP1 (via phosphorylated form and BSD domain); this interaction is enhanced in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation and activates AKT1 (PubMed:23300339). Interacts with PKHM3 (PubMed:19028694). Interacts with FKBP5/FKBP51; promoting interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (By similarity). Interacts with TMEM175; leading to formation of the lysoK(GF) complex (By similarity). P31750; Q9Z2V5: Hdac6; NbExp=2; IntAct=EBI-298707, EBI-1009256; P31750; P07901: Hsp90aa1; NbExp=6; IntAct=EBI-298707, EBI-78930; P31750; P05480: Src; NbExp=3; IntAct=EBI-298707, EBI-298680; P31750; Q8K4K2: Trib3; NbExp=5; IntAct=EBI-298707, EBI-448962; P31750; P62991: Ubc; NbExp=3; IntAct=EBI-298707, EBI-413074; P31750; P32121: ARRB2; Xeno; NbExp=3; IntAct=EBI-298707, EBI-714559; P31750; Q1W6H9: FAM110C; Xeno; NbExp=3; IntAct=EBI-298707, EBI-3942563; P31750; Q8TCU6: PREX1; Xeno; NbExp=2; IntAct=EBI-298707, EBI-1046542; P31750; P03165: X; Xeno; NbExp=2; IntAct=EBI-298707, EBI-7683985; Cytoplasm cleus ll membrane Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1) (By similarity). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles. Widely expressed. Low levels found in liver with slightly higher levels present in thymus and testis. Expressed in trophoblast and vessel endothelial cells of the placenta and in the brain at 14.5 dpc (at protein level). Binding of the PH domain to phosphatidylinositol 3,4,5- trisphosphate (PI(3,4,5)P3) following phosphatidylinositol 3-kinase alpha (PIK3CA) activity results in its targeting to the plasma membrane. The PH domain mediates interaction with TNK2 and Tyr-176 is also essential for this interaction. The AGC-kinase C-terminal mediates interaction with THEM4. O-GlcNAcylation at Thr-305 and Thr-312 inhibits activating phosphorylation at Thr-308 via disrupting the interaction between AKT1 and PDPK1 (By similarity). O-GlcNAcylation at Ser-473 also probably interferes with phosphorylation at this site (PubMed:18570920, PubMed:18288188). Phosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity (PubMed:26095253, PubMed:26107252, PubMed:32350463). Activated TNK2 phosphorylates it on Tyr-176 resulting in its binding to the anionic plasma membrane phospholipid PA (By similarity). This phosphorylated form localizes to the plasma membrane, where it is targeted by PDPK1 and PDPK2 for further phosphorylations on Thr-308 and Ser-473 leading to its activation (By similarity). Ser-473 phosphorylation by mTORC2 favors Thr-308 phosphorylation by PDPK1 and PRKDC (PubMed:26095253, PubMed:26107252, PubMed:32350463). Phosphorylated at Thr-308 and Ser-473 by IKBKE and TBK1. Ser-473 phosphorylation is enhanced by signaling through activated FLT3 (By similarity). Ser-473 is dephosphorylated by PHLPP (By similarity). Dephosphorylated at Thr-308 and Ser-473 by PP2A phosphatase (PubMed:32350463). The phosphorylated form of PPP2R5B is required for bridging AKT1 with PP2A phosphatase (By similarity). Ser-473 is dephosphorylated by CPPED1, leading to termination of signaling (By similarity). AIM2 acts as an inhibitor of AKT1 by inhibiting phosphorylation Ser-473: AIM2 acts both by inhibiting the activity of PRKDC/DNA-PK kinase and promoting dephosphorylation by PP2A phosphatase (PubMed:26107252, PubMed:32350463). Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. TRAF6-induced 'Lys-63'-linked AKT1 ubiquitination is critical for phosphorylation and activation. When ubiquitinated, it translocates to the plasma membrane, where it becomes phosphorylated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome. Also ubiquitinated by TRIM13 leading to its proteasomal degradation. Ubiquitinated via 'Lys-48'-linked polyubiquitination by ZNRF1, leading to its degradation by the proteasome. Phosphorylated, undergoes 'Lys-48'-linked polyubiquitination preferentially at Lys-284 catalyzed by MUL1, leading to its proteasomal degradation. Acetylated on Lys-14 and Lys-20 by the histone acetyltransferases EP300 and KAT2B. Acetylation results in reduced phosphorylation and inhibition of activity. Deacetylated at Lys-14 and Lys-20 by SIRT1. SIRT1-mediated deacetylation relieves the inhibition (By similarity). Cleavage by caspase-3/CASP3 (PubMed:12124386). Cleaved at the caspase-3 consensus site Asp-462 during apoptosis, resulting in down- regulation of the AKT signaling pathway and decreased cell survival (PubMed:12124386). Show fetal growth impairment and reduced vascularization in the placenta; majority of pups died within 10 days. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. In light of strong homologies in the primary amino acid sequence, the 3 AKT kinases were long surmised to play redundant and overlapping roles. More recent studies has brought into question the redundancy within AKT kinase isoforms and instead pointed to isoform specific functions in different cellular events and diseases. AKT1 is more specifically involved in cellular survival pathways, by inhibiting apoptotic processes; whereas AKT2 is more specific for the insulin receptor signaling pathway. Moreover, while AKT1 and AKT2 are often implicated in many aspects of cellular transformation, the 2 isoforms act in a complementary opposing manner. The role of AKT3 is less clear, though it appears to be predominantly expressed in brain. nucleotide binding osteoblast differentiation maternal placenta development positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation cell migration involved in sprouting angiogenesis protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein kinase C binding protein binding calmodulin binding ATP binding phosphatidylinositol-3,4,5-trisphosphate binding nucleus cytoplasm mitochondrion spindle cytosol plasma membrane cell-cell junction carbohydrate metabolic process glycogen metabolic process glycogen biosynthetic process regulation of glycogen biosynthetic process glucose metabolic process translation regulation of translation protein phosphorylation negative regulation of protein kinase activity protein import into nucleus apoptotic process activation-induced cell death of T cells inflammatory response cellular response to DNA damage stimulus response to oxidative stress cytoskeleton organization signal transduction epidermal growth factor receptor signaling pathway I-kappaB kinase/NF-kappaB signaling multicellular organism development germ cell development nervous system development aging positive regulation of cell proliferation insulin receptor signaling pathway apoptotic mitochondrial changes carbohydrate transport response to hormone response to organic substance negative regulation of autophagy positive regulation of gene expression negative regulation of gene expression negative regulation of plasma membrane long-chain fatty acid transport positive regulation of fibroblast migration positive regulation of sodium ion transport positive regulation of glucose metabolic process positive regulation of mitochondrial membrane potential negative regulation of endopeptidase activity regulation of neuron projection development phosphatidylinositol 3-kinase signaling microtubule cytoskeleton membrane kinase activity phosphorylation protein ubiquitination transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation enzyme binding protein kinase binding spinal cord development cell projection organization protein catabolic process hyaluronan metabolic process nitric-oxide synthase regulator activity positive regulation of cell growth regulation of cell migration negative regulation of protein ubiquitination regulation of myelination lipopolysaccharide-mediated signaling pathway vesicle negative regulation of fatty acid beta-oxidation positive regulation of endodeoxyribonuclease activity negative regulation of protein binding response to food positive regulation of cellular protein metabolic process peripheral nervous system myelin maintenance positive regulation of proteasomal ubiquitin-dependent protein catabolic process GTPase activating protein binding cellular response to insulin stimulus regulation of protein localization macromolecular complex positive regulation of peptidyl-serine phosphorylation response to fluid shear stress cellular response to reactive oxygen species intracellular signal transduction interleukin-18-mediated signaling pathway cellular response to vascular endothelial growth factor stimulus ciliary basal body cellular response to decreased oxygen levels NIK/NF-kappaB signaling glucose homeostasis identical protein binding protein homodimerization activity regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process phosphatidylinositol-3,4-bisphosphate binding protein kinase B signaling positive regulation of blood vessel endothelial cell migration positive regulation of nitric oxide biosynthetic process positive regulation of fat cell differentiation positive regulation of glycogen biosynthetic process positive regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell size negative regulation of proteolysis positive regulation of transcription, DNA-templated positive regulation of vasoconstriction positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import negative regulation of JNK cascade positive regulation of organ growth positive regulation of lipid biosynthetic process insulin-like growth factor receptor signaling pathway positive regulation of smooth muscle cell proliferation positive regulation of nitric-oxide synthase activity positive regulation of sequence-specific DNA binding transcription factor activity striated muscle cell differentiation protein phosphatase 2A binding response to growth hormone glycogen cell differentiation involved in embryonic placenta development labyrinthine layer blood vessel development response to UV-A cellular response to mechanical stimulus cellular response to cadmium ion cellular response to tumor necrosis factor cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus cellular response to prostaglandin E stimulus cellular response to organic cyclic compound cellular response to hypoxia 14-3-3 protein binding establishment of protein localization to mitochondrion maintenance of protein location in mitochondrion negative regulation of release of cytochrome c from mitochondria cellular response to granulocyte macrophage colony-stimulating factor stimulus execution phase of apoptosis positive regulation of G1/S transition of mitotic cell cycle positive regulation of protein localization to nucleus cellular response to peptide negative regulation of leukocyte cell-cell adhesion positive regulation of protein localization to plasma membrane positive regulation of I-kappaB phosphorylation cellular response to nerve growth factor stimulus response to insulin-like growth factor stimulus positive regulation of protein localization to cell surface negative regulation of lymphocyte migration negative regulation of intrinsic apoptotic signaling pathway uc007pex.1 uc007pex.2 uc007pex.3 
ENSMUST00000001792.12 Il16 ENSMUST00000001792.12 interleukin 16, transcript variant 2 (from RefSeq NM_010551.4) ENSMUST00000001792.1 ENSMUST00000001792.10 ENSMUST00000001792.11 ENSMUST00000001792.2 ENSMUST00000001792.3 ENSMUST00000001792.4 ENSMUST00000001792.5 ENSMUST00000001792.6 ENSMUST00000001792.7 ENSMUST00000001792.8 ENSMUST00000001792.9 IL16_MOUSE NM_010551 O54824 O70236 Q3TEM4 Q5DTR5 Q8R0G5 Q9QZP6 uc009ids.1 uc009ids.2 uc009ids.3 Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA- binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. Homotetramer (Probable). Isoform 2 interacts with GRIN2A. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C. Isoform 2 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GABPB1. Isoform 2 interacts (via PDZ 3 domain) with HDAC3 (By similarity). O54824; Q7TS72: Itpkc; NbExp=3; IntAct=EBI-641708, EBI-648015; Secreted [Isoform 1]: Cytoplasm Note=Colocalizes with GRIN2C in neuronal cell bodies and neurites. [Isoform 2]: Cytoplasm. Nucleus Event=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=NIL-16; IsoId=O54824-1; Sequence=Displayed; Name=2; Synonyms=Pro-IL-16; IsoId=O54824-2; Sequence=VSP_037460; Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung. Synthesized as a chemo-attractant inactive precursor which is proteolytically cleaved by caspase-3 to yield IL-16. [Isoform 1]: Produced by alternative promoter usage. Is probably proteolytically processed to yield IL-16. [Isoform 2]: Produced by alternative promoter usage. Is proteolytically processed to yield IL-16. cytokine activity protein binding extracellular region extracellular space nucleus cytoplasm cytosol plasma membrane chemotaxis signal transduction nuclear speck leukocyte chemotaxis CD4 receptor binding induction of positive chemotaxis regulation of calcium ion transport uc009ids.1 uc009ids.2 uc009ids.3 
ENSMUST00000001801.11 Tcirg1 ENSMUST00000001801.11 T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3, transcript variant 2 (from RefSeq NM_001136091.2) ENSMUST00000001801.1 ENSMUST00000001801.10 ENSMUST00000001801.2 ENSMUST00000001801.3 ENSMUST00000001801.4 ENSMUST00000001801.5 ENSMUST00000001801.6 ENSMUST00000001801.7 ENSMUST00000001801.8 ENSMUST00000001801.9 NM_001136091 Oc116 Q9JHF5 Q9JHF5_MOUSE Tcirg1 uc008fxm.1 uc008fxm.2 uc008fxm.3 Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. Membrane ; Multi- pass membrane protein Belongs to the V-ATPase 116 kDa subunit family. vacuolar proton-transporting V-type ATPase, V0 domain ossification osteoclast proliferation immunoglobulin production nucleus mitochondrion lysosome late endosome plasma membrane ion transport cellular calcium ion homeostasis apoptotic process inflammatory response vacuolar acidification protein catabolic process in the vacuole regulation of proton transport response to silver ion regulation of gene expression hydrogen ion transmembrane transporter activity membrane integral component of membrane immunoglobulin mediated immune response macroautophagy apical plasma membrane vacuolar proton-transporting V-type ATPase complex optic nerve development myeloid cell differentiation B cell differentiation T cell differentiation osteoclast differentiation secretory granule membrane phagocytic vesicle membrane proton-transporting V-type ATPase, V0 domain memory T cell activation T-helper 1 cell activation odontogenesis T cell homeostasis tooth eruption phagocytic vesicle bone resorption regulation of osteoblast differentiation pH reduction proton-transporting ATPase activity, rotational mechanism homeostasis of number of cells regulation of insulin secretion ATPase binding retina development in camera-type eye hematopoietic stem cell homeostasis enamel mineralization cellular response to cytokine stimulus interferon-gamma secretion phagosome acidification dentin mineralization hydrogen ion transmembrane transport uc008fxm.1 uc008fxm.2 uc008fxm.3 
ENSMUST00000001802.10 Naglu ENSMUST00000001802.10 alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB), transcript variant 1 (from RefSeq NM_013792.3) ENSMUST00000001802.1 ENSMUST00000001802.2 ENSMUST00000001802.3 ENSMUST00000001802.4 ENSMUST00000001802.5 ENSMUST00000001802.6 ENSMUST00000001802.7 ENSMUST00000001802.8 ENSMUST00000001802.9 NM_013792 Naglu O88325 O88325_MOUSE uc007lna.1 uc007lna.2 uc007lna.3 uc007lna.4 uc007lna.5 lysosome organization cerebellar Purkinje cell layer development middle ear morphogenesis locomotor rhythm retinal rod cell development inner ear receptor cell development extracellular exosome uc007lna.1 uc007lna.2 uc007lna.3 uc007lna.4 uc007lna.5 
ENSMUST00000001806.10 Coasy ENSMUST00000001806.10 Coenzyme A synthase, transcript variant 2 (from RefSeq NR_155015.1) A2BFA8 COASY_MOUSE Coasy ENSMUST00000001806.1 ENSMUST00000001806.2 ENSMUST00000001806.3 ENSMUST00000001806.4 ENSMUST00000001806.5 ENSMUST00000001806.6 ENSMUST00000001806.7 ENSMUST00000001806.8 ENSMUST00000001806.9 NR_155015 Q3TVZ2 Q8K3Y4 Q9DBL7 Ukr1 uc007lnc.1 uc007lnc.2 uc007lnc.3 This gene encodes the bifunctional protein coenzyme A (CoA) synthase which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this protein catalyzes the conversion of phosphopantetheine into dephospho-CoA while its dephospho-CoA kinase domain completes the final step by phosphorylating dephospho-CoA to form CoA. [provided by RefSeq, Apr 2015]. Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. Reaction=(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate; Xref=Rhea:RHEA:19801, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57328, ChEBI:CHEBI:61723; EC=2.7.7.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19802; Evidence=; Reaction=3'-dephospho-CoA + ATP = ADP + CoA + H(+); Xref=Rhea:RHEA:18245, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:456216; EC=2.7.1.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18246; Evidence=; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 4/5. Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 5/5. Monomer. Cytoplasm Mitochondrion matrix Note=The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but this protein is also present in cell lysate. Widely expressed with highest levels in kidney and lowest levels in colon, lung, intestine, and spleen. In the central section; belongs to the eukaryotic CoaD family. Sequence=AAH20046.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding catalytic activity dephospho-CoA kinase activity pantetheine-phosphate adenylyltransferase activity ATP binding nucleoplasm cytoplasm mitochondrion mitochondrial matrix cytosol metabolic process biosynthetic process coenzyme A biosynthetic process kinase activity phosphorylation transferase activity nucleotidyltransferase activity uc007lnc.1 uc007lnc.2 uc007lnc.3 
ENSMUST00000001809.15 Pabpc1 ENSMUST00000001809.15 poly(A) binding protein, cytoplasmic 1 (from RefSeq NM_008774.3) ENSMUST00000001809.1 ENSMUST00000001809.10 ENSMUST00000001809.11 ENSMUST00000001809.12 ENSMUST00000001809.13 ENSMUST00000001809.14 ENSMUST00000001809.2 ENSMUST00000001809.3 ENSMUST00000001809.4 ENSMUST00000001809.5 ENSMUST00000001809.6 ENSMUST00000001809.7 ENSMUST00000001809.8 ENSMUST00000001809.9 NM_008774 P29341 PABP1_MOUSE Pabp1 Q99L36 uc007vmx.1 uc007vmx.2 uc007vmx.3 uc007vmx.4 Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability. May form homodimers. Component of a multisubunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Directly interacts with IGF2BP1. Part of a complex associated with the FOS mCRD domain and consisting of HNRPD, SYNCRIP, PAIP1 and CSDE1/UNR. Interacts with PAIP1 and PAIP2 (via the PABPC1-interacting motifs PAM1 and PAM2). Interacts with PAIP1 with a 1:1 stoichiometry and with PAIP2 with a 1:2 stoichiometry (By similarity). The interaction with CSDE1 is direct and RNA-independent (PubMed:15314026). Found in a mRNP complex with YBX2 (PubMed:10076007). Interacts with TENT2/GLD2 (PubMed:17927953). Identified in the spliceosome C complex. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. The interaction with DDX3X is direct and RNA-independent. This interaction increases in stressed cells and decreases during cell recovery. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NXF1/TAP (By similarity). Interacts with PIWIL1 (PubMed:19020299). Interacts with AGO1, AGO2, GSPT1 and GSPT2. Interacts with LARP4B. Interacts (via the second and third RRM domains and the C-terminus) with PAIP2B (via central acidic portion and C-terminus). Forms a complex with LARP1 and SHFL. Interacts with LARP4. Interacts with ZFC3H1 in a RNase-sensitive manner. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner. Interacts with TENT5C; the interaction has no effect on TENT5C poly(A) polymerase function. Interacts with G3BP1 and G3BP2 (By similarity). Interacts with ENDOV; the interaction is RNA-dependent and stimulates ENDOV activity (By similarity). Interacts with UPF1; the interaction is RNA-dependent (By similarity). Interacts with IGF2BP2 and IGF2BP3. May interact with SETX. Interacts with RBM46 (PubMed:36001654). Interacts with PAN3 isoform 1/Pan3L and isoform 3/Pan3S (via N-terminus); interaction with isoform 1 is less efficient than with isoform 3 (By similarity). Cytoplasm Cytoplasm, Stress granule Nucleus Cell projection, lamellipodium Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). Shuttles between the cytoplasm and the nucleus (By similarity). During stress and in the absence of DDX3X, localizes to the nucleus (By similarity). At the leading edge of migrating fibroblasts, colocalizes with DDX3X (By similarity). Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with ENDOV (By similarity). The RNA-binding domains RRM1 and RRM2 and the C-terminus (last 138 amino acids) regions interact respectively with the PABPC1- interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1, respectively. The RNA-binding domains RRM2 and RRM3 and the C-terminus (last 138 amino acids) regions interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP2, respectively. Phosphorylated by MAPKAPK2. Methylated by CARM1. Arg-493 is dimethylated, probably to asymmetric dimethylarginine (By similarity). Belongs to the polyadenylate-binding protein type-1 family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding nucleus spliceosomal complex cytoplasm cytosol mRNA processing protein C-terminus binding poly(A) binding poly(U) RNA binding RNA splicing cytoplasmic stress granule dendrite gene silencing by RNA cytoplasmic ribonucleoprotein granule positive regulation of viral genome replication synapse positive regulation of nuclear-transcribed mRNA poly(A) tail shortening catalytic step 2 spliceosome positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay messenger ribonucleoprotein complex ribonucleoprotein complex negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay uc007vmx.1 uc007vmx.2 uc007vmx.3 uc007vmx.4 
ENSMUST00000001812.5 Smo ENSMUST00000001812.5 smoothened, frizzled class receptor (from RefSeq NM_176996.5) ENSMUST00000001812.1 ENSMUST00000001812.2 ENSMUST00000001812.3 ENSMUST00000001812.4 NM_176996 Q4VBD5 Q4VBD5_MOUSE Smo uc009bef.1 uc009bef.2 uc009bef.3 uc009bef.4 Cell membrane ; Multi-pass membrane protein Cell projection, cilium Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor Fz/Smo family. Lacks conserved residue(s) required for the propagation of feature annotation. transmembrane signaling receptor activity patched binding Golgi apparatus plasma membrane caveola cell surface receptor signaling pathway smoothened signaling pathway multicellular organism development drug binding positive regulation of gene expression membrane integral component of membrane positive regulation of cell migration intracellular membrane-bounded organelle detection of cell density by contact stimulus involved in contact inhibition renal system development uc009bef.1 uc009bef.2 uc009bef.3 uc009bef.4 
ENSMUST00000001818.5 Crnkl1 ENSMUST00000001818.5 crooked neck pre-mRNA splicing factor 1 (from RefSeq NM_025820.3) CRNL1_MOUSE ENSMUST00000001818.1 ENSMUST00000001818.2 ENSMUST00000001818.3 ENSMUST00000001818.4 NM_025820 P63154 Q542E8 Q9CQC1 uc008mrz.1 uc008mrz.2 uc008mrz.3 Involved in pre-mRNA splicing process. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre- mRNAs. Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro containing CRNKL1, HPRP8BP and SNRPB2 (By similarity). Component of the minor spliceosome, which splices U12-type introns (By similarity). Interacts with PPIL2 (via the PPIase cyclophilin-type domain); they may form a trimeric complex with HSP90 (PubMed:15189447). Nucleus Nucleus speckle Note=Colocalizes with core spliceosomal snRNP proteins. Belongs to the crooked-neck family. spliceosomal complex assembly mRNA splicing, via spliceosome Prp19 complex RNA binding nucleus spliceosomal complex RNA processing mRNA processing RNA splicing nuclear speck U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome post-mRNA release spliceosomal complex uc008mrz.1 uc008mrz.2 uc008mrz.3 
ENSMUST00000001824.7 Folh1 ENSMUST00000001824.7 folate hydrolase 1, transcript variant 1 (from RefSeq NM_016770.3) ENSMUST00000001824.1 ENSMUST00000001824.2 ENSMUST00000001824.3 ENSMUST00000001824.4 ENSMUST00000001824.5 ENSMUST00000001824.6 FOLH1_MOUSE Mopsm NM_016770 Naalad1 O35409 Q0VDM5 Q9DCC2 uc009ifh.1 uc009ifh.2 uc009ifh.3 uc009ifh.4 Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. Reaction=Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.; EC=3.4.17.21; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit. Required for NAALADase activity.; The NAALADase and folate hydrolase activities are inhibited by quisqualic acid. Homodimer. Cell membrane ; Single-pass type II membrane protein Expressed predominantly in the hippocampal region of the brain and in kidney. Lower levels in the ovary, testis and mandibular gland. The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal. Belongs to the peptidase M28 family. M28B subfamily. There are amino acid differences between the sequence shown in fig.1 (PubMed:11210180) and the sequence deposited in the database (AF026380). The sequence from fig.1 shows only 3 conflicts between PubMed:11210180 and PubMed:16141072. These are at AA positions 141, 240 and 287. catalytic activity carboxypeptidase activity metallocarboxypeptidase activity plasma membrane integral component of plasma membrane proteolysis folic acid-containing compound metabolic process metabolic process peptidase activity metallopeptidase activity cell surface membrane integral component of membrane hydrolase activity dipeptidase activity C-terminal protein deglutamylation positive regulation of apoptotic process metal ion binding Ac-Asp-Glu binding tetrahydrofolyl-poly(glutamate) polymer binding uc009ifh.1 uc009ifh.2 uc009ifh.3 uc009ifh.4 
ENSMUST00000001825.9 Chordc1 ENSMUST00000001825.9 cysteine and histidine rich domain containing 1 (from RefSeq NM_025844.2) CHRD1_MOUSE Chp1 ENSMUST00000001825.1 ENSMUST00000001825.2 ENSMUST00000001825.3 ENSMUST00000001825.4 ENSMUST00000001825.5 ENSMUST00000001825.6 ENSMUST00000001825.7 ENSMUST00000001825.8 Morgana NM_025844 Q9CSI5 Q9D1P4 uc009ogm.1 uc009ogm.2 uc009ogm.3 Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co- chaperone for HSP90 (PubMed:16083881). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:16083881). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (By similarity). Involved in stress response (PubMed:20493909). Prevents tumorigenesis (By similarity). Interacts with HSP90AA1, HSP90AB1 and PPP5C. Interacts with ROCK1 and ROCK2 (By similarity). Ubiquitously expressed. Highly expressed in spleen, lung and brain (at protein level). Expressed in proliferating myoblasts and its expression remained steady after. Its expression undergoes diurnal and circadian changes in hypothalamus. Highly expressed during the dark-light transition (ZT20.5 (zeitgeber time 20.5) and ZT2.5). Weakly expressed at ZT8.5 and highly expressed at ZT14.5 at P6. At P6 highly expressed at ZT14.5 in hippocampus, prefrontal cortex and cerebellum. First detected and widely distributed at P1 and that continued throughout postnatal development. Expression is evident in the cortical plate (CP) at 17 dpc. Lower levels of expression is also evident in intermediate (IZ) and subventricular (SVZ) zones at this age. A more diffuse expression pattern is evident in early postnatal cortex with only slight differences in intensity throughout cortical layers. By P14, a more laminated distribution pattern becomes evident with a punctate distribution apparent in deep cortical layers. By Heat shock in a HSF1-dependent manner. Results in centrosome amplification and lethality. Cells become polyploid or undergo apoptosis. Embryos are no longer detected after 3.5 dpc. protein binding ATP binding zinc ion binding regulation of centrosome duplication ADP binding metal ion binding Hsp90 protein binding chaperone-mediated protein folding regulation of cellular response to heat negative regulation of Rho-dependent protein serine/threonine kinase activity calcium ion binding uc009ogm.1 uc009ogm.2 uc009ogm.3 
ENSMUST00000001834.4 Rtcb ENSMUST00000001834.4 RNA 2',3'-cyclic phosphate and 5'-OH ligase (from RefSeq NM_145422.4) D10Wsu52e ENSMUST00000001834.1 ENSMUST00000001834.2 ENSMUST00000001834.3 NM_145422 Q3TA04 Q3TI25 Q3UDW6 Q99LF4 RTCB_MOUSE Rtcb uc007gni.1 uc007gni.2 uc007gni.3 Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity). Essential during post-implantation development of embryos. Reaction=a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho- ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP; Xref=Rhea:RHEA:68076, Rhea:RHEA-COMP:10463, Rhea:RHEA-COMP:13936, Rhea:RHEA-COMP:17355, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58115, ChEBI:CHEBI:83062, ChEBI:CHEBI:138284, ChEBI:CHEBI:173118; EC=6.5.1.8; Evidence=; Reaction=a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl- ribonucleotide-RNA + diphosphate + GMP + H(+); Xref=Rhea:RHEA:68080, Rhea:RHEA-COMP:10464, Rhea:RHEA-COMP:13936, Rhea:RHEA-COMP:17355, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58115, ChEBI:CHEBI:83064, ChEBI:CHEBI:138284, ChEBI:CHEBI:173118; EC=6.5.1.8; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. Catalytic component of the tRNA-splicing ligase complex. Nucleus Cytoplasm Note=Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low. Ubiquitously expressed. Highly expressed in the epididymis with predominant enrichment in the initial segment. During sexual maturation, it is expressed in the caput epididymides. Down-regulated in the epididymis upon castration. Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. Belongs to the RtcB family. nucleotide binding tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate in utero embryonic development placenta development RNA ligase (ATP) activity ATP binding nucleus nuclear envelope nucleoplasm cytoplasm endoplasmic reticulum membrane cytosol tRNA splicing, via endonucleolytic cleavage and ligation RNA processing tRNA processing RNA ligase activity ligase activity vinculin binding intracellular membrane-bounded organelle metal ion binding tRNA-splicing ligase complex uc007gni.1 uc007gni.2 uc007gni.3 
ENSMUST00000001836.11 Pwp1 ENSMUST00000001836.11 PWP1 homolog, endonuclein (from RefSeq NM_133993.3) ENSMUST00000001836.1 ENSMUST00000001836.10 ENSMUST00000001836.2 ENSMUST00000001836.3 ENSMUST00000001836.4 ENSMUST00000001836.5 ENSMUST00000001836.6 ENSMUST00000001836.7 ENSMUST00000001836.8 ENSMUST00000001836.9 NM_133993 PWP1_MOUSE Q99LL5 Q9D6T6 uc007gnd.1 uc007gnd.2 uc007gnd.3 uc007gnd.4 Chromatin-associated factor that regulates transcription (By similarity). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (By similarity). Regulates the epigenetic status of rDNA (By similarity). Associates with the RNA polymerase (Pol I) complex. Interacts with POLR1E. Nucleus Nucleus, nucleolus Chromosome Note=Associates with chromatin regions of rDNA. Belongs to the WD repeat PWP1 family. nucleus chromosome nucleolus Golgi apparatus negative regulation of peptidyl-serine phosphorylation of STAT protein histone H4-K20 trimethylation ribosome biogenesis positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter H4K20me3 modified histone binding positive regulation of stem cell differentiation uc007gnd.1 uc007gnd.2 uc007gnd.3 uc007gnd.4 
ENSMUST00000001845.13 Capns1 ENSMUST00000001845.13 Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (PubMed:10825211). (from UniProt O88456) A0A0R4IZW8 BC090988 CPNS1_MOUSE Capn4 D3YW48 ENSMUST00000001845.1 ENSMUST00000001845.10 ENSMUST00000001845.11 ENSMUST00000001845.12 ENSMUST00000001845.2 ENSMUST00000001845.3 ENSMUST00000001845.4 ENSMUST00000001845.5 ENSMUST00000001845.6 ENSMUST00000001845.7 ENSMUST00000001845.8 ENSMUST00000001845.9 O88456 Q3V0X5 Q5BKQ2 Q8CEI2 Q8VEK4 Q9R1C5 uc009gdr.1 uc009gdr.2 uc009gdr.3 Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (PubMed:10825211). Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates (By similarity). Cytoplasm Cell membrane Note=Translocates to the plasma membrane upon calcium binding. The contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer. EF-hand domains are paired. EF-hand 1 is paired with EF-hand 2 and EF-hand 3 is paired with EF-hand 4. The fifth EF-hand domain, left unpaired, does not bind the calcium but is responsible of the dimerization by EF-embrace. The first four EF-hand domains bind calcium, however it is not sure if the binding of EF-hand 4 to calcium is physiologically relevant. Embryonic lethality by 11.5 dpc, with indications of defects in both vasculogenesis and erythropoiesis. calcium-dependent cysteine-type endopeptidase activity calcium ion binding protein binding cytoplasm cytosol plasma membrane proteolysis membrane metal ion binding protein heterodimerization activity uc009gdr.1 uc009gdr.2 uc009gdr.3 
ENSMUST00000001854.12 Slc7a10 ENSMUST00000001854.12 solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 (from RefSeq NM_017394.4) AAA1_MOUSE Asc1 ENSMUST00000001854.1 ENSMUST00000001854.10 ENSMUST00000001854.11 ENSMUST00000001854.2 ENSMUST00000001854.3 ENSMUST00000001854.4 ENSMUST00000001854.5 ENSMUST00000001854.6 ENSMUST00000001854.7 ENSMUST00000001854.8 ENSMUST00000001854.9 NM_017394 P63115 Q9CW25 Q9JMH8 uc009gjn.1 uc009gjn.2 uc009gjn.3 uc009gjn.4 Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion (PubMed:10734121) (By similarity). Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons (PubMed:25755256, PubMed:27759100). At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission (By similarity). May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment (PubMed:33707431). Reaction=glycine(out) + L-alanine(in) = glycine(in) + L-alanine(out); Xref=Rhea:RHEA:74019, ChEBI:CHEBI:57305, ChEBI:CHEBI:57972; Evidence=; Reaction=L-alanine(in) + L-serine(out) = L-alanine(out) + L-serine(in); Xref=Rhea:RHEA:74023, ChEBI:CHEBI:33384, ChEBI:CHEBI:57972; Evidence=; Reaction=L-alanine(in) + L-threonine(out) = L-alanine(out) + L- threonine(in); Xref=Rhea:RHEA:74027, ChEBI:CHEBI:57926, ChEBI:CHEBI:57972; Evidence=; Reaction=L-alanine(in) + L-cysteine(out) = L-alanine(out) + L- cysteine(in); Xref=Rhea:RHEA:74031, ChEBI:CHEBI:35235, ChEBI:CHEBI:57972; Evidence=; Reaction=2-aminoisobutanoate(out) + L-alanine(in) = 2- aminoisobutanoate(in) + L-alanine(out); Xref=Rhea:RHEA:74063, ChEBI:CHEBI:57972, ChEBI:CHEBI:193090; Evidence=; Reaction=D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out); Xref=Rhea:RHEA:74035, ChEBI:CHEBI:35247, ChEBI:CHEBI:57972; Evidence=; Reaction=D-alanine(out) + L-alanine(in) = D-alanine(in) + L- alanine(out); Xref=Rhea:RHEA:74039, ChEBI:CHEBI:57416, ChEBI:CHEBI:57972; Evidence=; Reaction=L-alanine(in) + L-valine(out) = L-alanine(out) + L-valine(in); Xref=Rhea:RHEA:74047, ChEBI:CHEBI:57762, ChEBI:CHEBI:57972; Evidence=; Reaction=L-alanine(in) + L-methionine(out) = L-alanine(out) + L- methionine(in); Xref=Rhea:RHEA:74043, ChEBI:CHEBI:57844, ChEBI:CHEBI:57972; Evidence=; Reaction=beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L- alanine(out); Xref=Rhea:RHEA:74059, ChEBI:CHEBI:57966, ChEBI:CHEBI:57972; Evidence=; Reaction=D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L- alanine(out); Xref=Rhea:RHEA:74055, ChEBI:CHEBI:35236, ChEBI:CHEBI:57972; Evidence=; Reaction=D-threonine(out) + L-alanine(in) = D-threonine(in) + L- alanine(out); Xref=Rhea:RHEA:74051, ChEBI:CHEBI:57757, ChEBI:CHEBI:57972; Evidence=; Reaction=D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D- serine(out); Xref=Rhea:RHEA:74299, ChEBI:CHEBI:35247, ChEBI:CHEBI:193151; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74300; Evidence=; Reaction=D-serine(in) = D-serine(out); Xref=Rhea:RHEA:29455, ChEBI:CHEBI:35247; Evidence=; Kinetic parameters: KM=23 uM for L-alanine ; KM=7.8 uM for glycine ; KM=11.3 uM for L-serine ; KM=19.3 uM for L-threonine ; KM=23.7 uM for L-cysteine ; KM=112 uM for L-valine ; KM=139 uM for L-methionine ; KM=160 uM for L-isoleucine ; KM=245 uM for L-leucine ; KM=368 uM for L-histidine ; KM=464 uM for L-phenylalanine ; KM=22.7 uM for 2-aminoisobutanoate ; KM=100 uM for D-alanine ; KM=52 uM for D-serine ; KM=281 uM for beta-alanine ; pH dependence: Active from pH 5.5 to 8.5. ; Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc. Cell membrane ulti-pass membrane protein Note=Colocalizes with OLIG2 in astrocytic processes (PubMed:34749773). Localizes to the plasma membrane in mature adipocytes and to intracellular structures in preadipocytes (PubMed:33707431). Highly expressed in brain and lung, and to a lesser extent in placenta and small intestine (PubMed:10734121). Expressed in a subpopulation of astrocytes enriched at glycinergic synapses in the spinal cord and brainstem (at protein level). Expressed in OLIG2- positive astrocytes of the lateral globus pallidus (at protein level) (PubMed:27759100, PubMed:34749773). Expressed in CD34-positive, DPP4- positive mesenchymal progenitors in developing subcutaneous adipose tissue (PubMed:33707431). Up-regulated upon adipocyte differentiation in response to INS. Down-regulated by treatment with rosiglitazone. Mutant mice develop hyperekplexia-like phenotype due to impaired glycinergic inhibitory transmission. Administration of glycine and L-serine reverses the phenotype. Belongs to the amino acid-polyamine-organocation (APC) superfamily. protein binding integral component of plasma membrane amino acid transport neutral amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity neutral amino acid transport membrane integral component of membrane transmembrane transporter activity D-alanine transport D-serine transport neuronal cell body transmembrane transport apical dendrite L-alpha-amino acid transmembrane transport uc009gjn.1 uc009gjn.2 uc009gjn.3 uc009gjn.4 
ENSMUST00000001872.5 Hoxd13 ENSMUST00000001872.5 homeobox D13 (from RefSeq NM_008275.4) A2ASM5 ENSMUST00000001872.1 ENSMUST00000001872.2 ENSMUST00000001872.3 ENSMUST00000001872.4 HXD13_MOUSE Hox-4.8 NM_008275 P70217 Q2VPB0 Q2VPB1 Q64177 uc008kdu.1 uc008kdu.2 uc008kdu.3 Sequence-specific transcription factor that binds gene promoters and activates their transcription (PubMed:23995701). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity). Nucleus Belongs to the Abd-B homeobox family. It is uncertain whether Met-1 or Met-9 is the initiator. RNA polymerase II core promoter proximal region sequence-specific DNA binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development pattern specification process anterior/posterior pattern specification gland morphogenesis embryonic limb morphogenesis male genitalia development prostate gland development response to testosterone limb morphogenesis regulation of cell proliferation embryonic digit morphogenesis sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter embryonic hindgut morphogenesis prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis morphogenesis of an epithelial fold branch elongation of an epithelium regulation of branching involved in prostate gland morphogenesis sequence-specific double-stranded DNA binding uc008kdu.1 uc008kdu.2 uc008kdu.3 
ENSMUST00000001878.6 Hoxd12 ENSMUST00000001878.6 homeobox D12 (from RefSeq NM_008274.3) ENSMUST00000001878.1 ENSMUST00000001878.2 ENSMUST00000001878.3 ENSMUST00000001878.4 ENSMUST00000001878.5 HXD12_MOUSE Hox-4.7 Hoxd-12 NM_008274 P23812 Q8BSN0 uc008kdv.1 uc008kdv.2 uc008kdv.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus. Expressed during development of the posterior part of the body. Belongs to the Abd-B homeobox family. Sequence=CAA41654.1; Type=Erroneous gene model prediction; Evidence=; skeletal system development DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated multicellular organism development pattern specification process embryonic digit morphogenesis sequence-specific DNA binding uc008kdv.1 uc008kdv.2 uc008kdv.3 
ENSMUST00000001884.14 Clpb ENSMUST00000001884.14 ClpB caseinolytic peptidase B, transcript variant 6 (from RefSeq NR_184442.1) CLPB_MOUSE Clpb ENSMUST00000001884.1 ENSMUST00000001884.10 ENSMUST00000001884.11 ENSMUST00000001884.12 ENSMUST00000001884.13 ENSMUST00000001884.2 ENSMUST00000001884.3 ENSMUST00000001884.4 ENSMUST00000001884.5 ENSMUST00000001884.6 ENSMUST00000001884.7 ENSMUST00000001884.8 ENSMUST00000001884.9 NR_184442 Q60649 Skd3 uc009ipc.1 uc009ipc.2 uc009ipc.3 Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. Plays a role in granulocyte differentiation. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Disaggregase activity is inhibited by ADP. Homododecamer when substrate-bound; the homododecamer consists of 2 homohexamers stacked head-to-head via ANK repeat-mediated interactions. The active substrate-bound form is likely to exist in a dynamic equilibrium between homohexamers and homododecamers. Homotetradecamer in the unbound state which is remodeled upon substrate binding into the homododecamer. Interacts with PHB and PHB2. Interacts with MAVS; the interaction is enhanced by Sendai virus infection. Mitochondrion intermembrane space Widely expressed, with highest levels in testis. Also expressed in heart, skeletal muscle and kidney. The ankyrin-repeat region is necessary for ATP-dependent protein disaggregase activity. It plays an important role in stabilizing the substrate-bound homododecamer by mediating contacts between the two homohexamers. Proteolytically cleaved by protease PARL. ATP-dependent protein disaggregase activity is stimulated by PARL-mediated cleavage of the N- terminal autoinhibitory peptide. Belongs to the ClpA/ClpB family. Despite its gene name, this protein differs in domain structure from bacterial clpB. Bacterial clpB contains two AAA modules, one in the N-terminal part of the protein and one in the C-terminal part, separated by a coiled coil, while vertebrate CLPB contains a single C-terminal AAA region and an N-terminal ANK repeat region which is absent from bacterial clpB. nucleotide binding ATP binding mitochondrion hydrolase activity ATPase activity cellular response to heat uc009ipc.1 uc009ipc.2 uc009ipc.3 
ENSMUST00000001900.9 Zdhhc4 ENSMUST00000001900.9 zinc finger, DHHC domain containing 4, transcript variant 1 (from RefSeq NM_028379.5) ENSMUST00000001900.1 ENSMUST00000001900.2 ENSMUST00000001900.3 ENSMUST00000001900.4 ENSMUST00000001900.5 ENSMUST00000001900.6 ENSMUST00000001900.7 ENSMUST00000001900.8 NM_028379 Q8R5E0 Q9D6H5 ZDHC4_MOUSE Zdhhc4 uc009ajz.1 uc009ajz.2 uc009ajz.3 uc009ajz.4 Palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates including the D(2) dopamine receptor DRD2. Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein The C-terminal di-lysine motif confers endoplasmic reticulum localization. The DHHC domain is required for palmitoyltransferase activity. Belongs to the DHHC palmitoyltransferase family. endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein-cysteine S-palmitoyltransferase activity uc009ajz.1 uc009ajz.2 uc009ajz.3 uc009ajz.4 
ENSMUST00000001920.13 Aif1l ENSMUST00000001920.13 allograft inflammatory factor 1-like (from RefSeq NM_145144.1) AIF1L_MOUSE ENSMUST00000001920.1 ENSMUST00000001920.10 ENSMUST00000001920.11 ENSMUST00000001920.12 ENSMUST00000001920.2 ENSMUST00000001920.3 ENSMUST00000001920.4 ENSMUST00000001920.5 ENSMUST00000001920.6 ENSMUST00000001920.7 ENSMUST00000001920.8 ENSMUST00000001920.9 Iba2 NM_145144 Q8C150 Q9EQX4 uc008jeg.1 uc008jeg.2 uc008jeg.3 Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function (By similarity). Homodimer (Potential). Monomer (By similarity). Cytoplasm, cytoskeleton Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Colocalizes with F- actin. Partially relocates to membrane ruffles in response to invading bacteria (By similarity). actin binding calcium ion binding cytoplasm cytoskeleton actin filament plasma membrane focal adhesion actin cytoskeleton membrane ruffle membrane macromolecular complex cell projection metal ion binding actin filament binding actin filament bundle assembly ruffle assembly uc008jeg.1 uc008jeg.2 uc008jeg.3 
ENSMUST00000001921.3 Cpa3 ENSMUST00000001921.3 carboxypeptidase A3, mast cell (from RefSeq NM_007753.2) Cpa3 ENSMUST00000001921.1 ENSMUST00000001921.2 NM_007753 Q542E3 Q542E3_MOUSE uc008osp.1 uc008osp.2 uc008osp.3 uc008osp.4 This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases and preproprotein that is proteolytically processed to generate a mature protein product. This product is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Homozygous knockout mice for this gene exhibit impaired mast cell development. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK088906.1, J05118.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Belongs to the peptidase M14 family. carboxypeptidase activity metallocarboxypeptidase activity proteolysis zinc ion binding uc008osp.1 uc008osp.2 uc008osp.3 uc008osp.4 
ENSMUST00000001950.12 Tollip ENSMUST00000001950.12 toll interacting protein, transcript variant 1 (from RefSeq NM_023764.4) ENSMUST00000001950.1 ENSMUST00000001950.10 ENSMUST00000001950.11 ENSMUST00000001950.2 ENSMUST00000001950.3 ENSMUST00000001950.4 ENSMUST00000001950.5 ENSMUST00000001950.6 ENSMUST00000001950.7 ENSMUST00000001950.8 ENSMUST00000001950.9 NM_023764 Q543N1 Q9D5P5 Q9QZ06 TOLIP_MOUSE uc009kmd.1 uc009kmd.2 uc009kmd.3 Component of the signaling pathway of IL-1 and Toll-like receptors (By similarity). Inhibits cell activation by microbial products (By similarity). Recruits IRAK1 to the IL-1 receptor complex (By similarity). Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (By similarity). The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (By similarity). Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Found in a complex with TOM1; interacts (via N-terminus) with TOM1 (via GAT domain); the interactions leads to TOM1- recruitment to endosomes and inhibition of TOLLIP binding to PtdIns(3)P (By similarity). Interacts with TOM1L2 (By similarity). Interacts with ATG8 family proteins (via the AIM motifs), and ubiquitin (via the CUE domain) (By similarity). Interacts with LRBA (By similarity). Q9QZ06; Q61730: Il1rap; NbExp=2; IntAct=EBI-74272, EBI-525035; Q9QZ06; Q62406: Irak1; NbExp=2; IntAct=EBI-74272, EBI-448533; Q9QZ06; O88746: Tom1; NbExp=2; IntAct=EBI-74272, EBI-74264; Cytoplasm Endosome Early endosome Note=Localized to endo/exosomal vesicles. Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney, thymus, pancreas and testis. Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins. The N-terminal TOM1-binding domain (residues 1-53) is a disordered domain that partially folds when bound to the GAT domain of TOM1. Belongs to the tollip family. immune system process interleukin-1, Type I receptor binding protein binding cytoplasm ubiquitin-dependent protein catabolic process autophagy inflammatory response signal transduction phosphorylation nuclear body kinase binding epithelial cell differentiation ubiquitin conjugating enzyme binding ubiquitin protein ligase binding SUMO binding positive regulation of protein sumoylation Toll-like receptor binding protein localization to endosome ubiquitin binding innate immune response perinuclear region of cytoplasm uc009kmd.1 uc009kmd.2 uc009kmd.3 
ENSMUST00000001963.14 Ace ENSMUST00000001963.14 angiotensin I converting enzyme, transcript variant 1 (from RefSeq NM_207624.6) Ace ENSMUST00000001963.1 ENSMUST00000001963.10 ENSMUST00000001963.11 ENSMUST00000001963.12 ENSMUST00000001963.13 ENSMUST00000001963.2 ENSMUST00000001963.3 ENSMUST00000001963.4 ENSMUST00000001963.5 ENSMUST00000001963.6 ENSMUST00000001963.7 ENSMUST00000001963.8 ENSMUST00000001963.9 NM_207624 Q3TU20 Q3TU20_MOUSE uc007lxu.1 uc007lxu.2 uc007lxu.3 Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region. Reaction=H2O + Leu-enkephalin = L-phenylalanyl-L-leucine + L- tyrosylglycylglycine; Xref=Rhea:RHEA:71487, ChEBI:CHEBI:15377, ChEBI:CHEBI:190689, ChEBI:CHEBI:190708, ChEBI:CHEBI:190710; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71488; Evidence=; Reaction=H2O + Met-enkephalin = L-phenylalanyl-L-methionine + L- tyrosylglycylglycine; Xref=Rhea:RHEA:71483, ChEBI:CHEBI:15377, ChEBI:CHEBI:189868, ChEBI:CHEBI:190708, ChEBI:CHEBI:190709; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71484; Evidence=; Reaction=H2O + Met-enkephalin-Arg-Phe = L-arginyl-L-phenylalanine + Met-enkephalin; Xref=Rhea:RHEA:70675, ChEBI:CHEBI:15377, ChEBI:CHEBI:189868, ChEBI:CHEBI:189869, ChEBI:CHEBI:189870; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70676; Evidence=; Reaction=H2O + neurotensin = L-isoleucyl-L-leucine + neurotensin(1-11); Xref=Rhea:RHEA:71475, ChEBI:CHEBI:15377, ChEBI:CHEBI:147362, ChEBI:CHEBI:190704, ChEBI:CHEBI:190706; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71476; Evidence=; Reaction=H2O + substance P = Gly-L-Leu-L-Met-NH2 + substance P(1-8); Xref=Rhea:RHEA:71463, ChEBI:CHEBI:15377, ChEBI:CHEBI:190692, ChEBI:CHEBI:190694, ChEBI:CHEBI:190699; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71464; Evidence=; Reaction=H2O + substance P = L-Leu-L-Met-NH2 + substance P(1-9); Xref=Rhea:RHEA:71459, ChEBI:CHEBI:15377, ChEBI:CHEBI:190692, ChEBI:CHEBI:190693, ChEBI:CHEBI:190700; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71460; Evidence=; Reaction=H2O + substance P = L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6); Xref=Rhea:RHEA:71471, ChEBI:CHEBI:15377, ChEBI:CHEBI:190692, ChEBI:CHEBI:190696, ChEBI:CHEBI:190697; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71472; Evidence=; Reaction=Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.; EC=3.4.15.1; Evidence=; Reaction=angiotensin I + H2O = angiotensin II + L-histidyl-L-leucine; Xref=Rhea:RHEA:63560, ChEBI:CHEBI:15377, ChEBI:CHEBI:58506, ChEBI:CHEBI:147350, ChEBI:CHEBI:147392; EC=3.4.15.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63561; Evidence=; Reaction=bradykinin + H2O = bradykinin(1-7) + L-Phe-L-Arg; Xref=Rhea:RHEA:71451, ChEBI:CHEBI:15377, ChEBI:CHEBI:132988, ChEBI:CHEBI:133147, ChEBI:CHEBI:147352; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71452; Evidence=; Reaction=goralatide + H2O = L-lysyl-L-proline + N-acetyl-L-seryl-L- aspartate; Xref=Rhea:RHEA:71455, ChEBI:CHEBI:15377, ChEBI:CHEBI:190701, ChEBI:CHEBI:190702, ChEBI:CHEBI:190703; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71456; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence=; Belongs to the peptidase M2 family. kidney development regulation of systemic arterial blood pressure by renin-angiotensin endopeptidase activity carboxypeptidase activity extracellular space lysosome endosome plasma membrane proteolysis drug binding peptidase activity metallopeptidase activity exopeptidase activity tripeptidyl-peptidase activity peptidyl-dipeptidase activity zinc ion binding external side of plasma membrane membrane integral component of membrane hydrolase activity chloride ion binding mitogen-activated protein kinase kinase binding bradykinin receptor binding hormone catabolic process peptide catabolic process metal ion binding beta-amyloid metabolic process arachidonic acid secretion mitogen-activated protein kinase binding regulation of angiotensin metabolic process extracellular exosome uc007lxu.1 uc007lxu.2 uc007lxu.3 
ENSMUST00000001965.14 Kcnh6 ENSMUST00000001965.14 potassium voltage-gated channel, subfamily H (eag-related), member 6 (from RefSeq NM_001037712.2) ENSMUST00000001965.1 ENSMUST00000001965.10 ENSMUST00000001965.11 ENSMUST00000001965.12 ENSMUST00000001965.13 ENSMUST00000001965.2 ENSMUST00000001965.3 ENSMUST00000001965.4 ENSMUST00000001965.5 ENSMUST00000001965.6 ENSMUST00000001965.7 ENSMUST00000001965.8 ENSMUST00000001965.9 Kcnh6 NM_001037712 Q32ME0 Q32ME0_MOUSE uc007lxx.1 uc007lxx.2 uc007lxx.3 Membrane ; Multi- pass membrane protein ion channel activity inward rectifier potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity integral component of plasma membrane ion transport potassium ion transport membrane integral component of membrane regulation of ion transmembrane transport regulation of membrane potential protein heterooligomerization transmembrane transport potassium ion transmembrane transport uc007lxx.1 uc007lxx.2 uc007lxx.3 
ENSMUST00000001974.11 Trmt1 ENSMUST00000001974.11 tRNA methyltransferase 1, transcript variant 5 (from RefSeq NM_001364176.1) A0A0R4IZW7 A0A0R4IZW7_MOUSE ENSMUST00000001974.1 ENSMUST00000001974.10 ENSMUST00000001974.2 ENSMUST00000001974.3 ENSMUST00000001974.4 ENSMUST00000001974.5 ENSMUST00000001974.6 ENSMUST00000001974.7 ENSMUST00000001974.8 ENSMUST00000001974.9 NM_001364176 Trmt1 uc009mmv.1 uc009mmv.2 uc009mmv.3 uc009mmv.4 tRNA binding RNA binding tRNA (guanine-N2-)-methyltransferase activity tRNA processing methyltransferase activity transferase activity tRNA methylation methylation metal ion binding uc009mmv.1 uc009mmv.2 uc009mmv.3 uc009mmv.4 
ENSMUST00000001975.6 Nacc1 ENSMUST00000001975.6 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing (from RefSeq NM_025788.3) Btbd14b ENSMUST00000001975.1 ENSMUST00000001975.2 ENSMUST00000001975.3 ENSMUST00000001975.4 ENSMUST00000001975.5 NACC1_MOUSE NM_025788 Nac1 Q7TSZ8 Q80X97 Q9CZ72 uc009mmu.1 uc009mmu.2 uc009mmu.3 uc009mmu.4 uc009mmu.5 Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Involved in the acute behavioral and neurological responses to cocaine and amphetamines. Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 and RCOR1 (By similarity). Q7TSZ8; Q8BX22: Sall4; NbExp=4; IntAct=EBI-5691985, EBI-2312582; Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation. Ubiquitously expressed with higher expression in the brain, kidney and liver, and at lower levels in heart, lung and testes. Mice are viable with no obvious developmental or physiological impairments. In addition, they do not display alterations in chronic responses to cocaine and amphetamine administration, but do however display significantly diminished acute behavioral and neurochemical responses to these drugs. protein binding nucleus nucleoplasm cytoplasm positive regulation of cell proliferation nuclear body cell junction intracellular membrane-bounded organelle negative regulation of transcription, DNA-templated protein homooligomerization uc009mmu.1 uc009mmu.2 uc009mmu.3 uc009mmu.4 uc009mmu.5 
ENSMUST00000001984.5 Ceacam9 ENSMUST00000001984.5 CEA cell adhesion molecule 9 (from RefSeq NM_011927.4) Cea5 Ceacam9 ENSMUST00000001984.1 ENSMUST00000001984.2 ENSMUST00000001984.3 ENSMUST00000001984.4 NM_011927 Q78T27 Q78T27_MOUSE uc009fhz.1 uc009fhz.2 uc009fhz.3 molecular_function cellular_component biological_process uc009fhz.1 uc009fhz.2 uc009fhz.3 
ENSMUST00000002008.7 Vsig2 ENSMUST00000002008.7 V-set and immunoglobulin domain containing 2 (from RefSeq NM_020518.2) Ctm Ctxl ENSMUST00000002008.1 ENSMUST00000002008.2 ENSMUST00000002008.3 ENSMUST00000002008.4 ENSMUST00000002008.5 ENSMUST00000002008.6 NM_020518 Q9CVA4 Q9D0T4 Q9Z109 VSIG2_MOUSE uc009ovb.1 uc009ovb.2 uc009ovb.3 Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z109-1; Sequence=Displayed; Name=2; IsoId=Q9Z109-2; Sequence=VSP_014120; Expressed in the stomach, colon and prostate. molecular_function integral component of plasma membrane biological_process membrane integral component of membrane uc009ovb.1 uc009ovb.2 uc009ovb.3 
ENSMUST00000002011.14 Esam ENSMUST00000002011.14 endothelial cell-specific adhesion molecule, transcript variant 2 (from RefSeq NR_136939.1) ENSMUST00000002011.1 ENSMUST00000002011.10 ENSMUST00000002011.11 ENSMUST00000002011.12 ENSMUST00000002011.13 ENSMUST00000002011.2 ENSMUST00000002011.3 ENSMUST00000002011.4 ENSMUST00000002011.5 ENSMUST00000002011.6 ENSMUST00000002011.7 ENSMUST00000002011.8 ENSMUST00000002011.9 ESAM_MOUSE Esam1 NR_136939 Q925F2 uc009ouz.1 uc009ouz.2 uc009ouz.3 uc009ouz.4 Can mediate aggregation most likely through a homophilic molecular interaction. Interacts with MAGI1. Cell junction, adherens junction Cell junction, tight junction Cell membrane ; Single-pass type I membrane protein Highly expressed in the heart and lung. Weakly expressed in the kidney and skin. Expression is restricted to the vascular endothelial cells. Expressed in the kidney, heart and tongue (at protein level). Also expressed on megakaryocytes and activated platelets. Expression in 8.5 dpc-9.5 dpc embryos is observed in embryonic blood vessels including the dorsal aorta, intersomitic arteries and the forming vascular plexus in the head as well as the cardiac outflow tract. By 10.5 dpc-11.5 dpc embryos expression is found in association with the all recognizable blood vessels and in association with cells lining the heart chambers. At 10.5-days embryos expression is associated with syncytiotrophoblasts and cytotrophoblasts as well as endothelial cells associated with blood vessels in the decidua. Expression decreased after mid-gestation from 15.5-day embryos. Up-regulated on the surface of platelets upon activation. plasma membrane cell-cell junction adherens junction bicellular tight junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction regulation of actin filament polymerization macromolecular complex cellular protein localization bicellular tight junction assembly cell-cell adhesion protein binding involved in cell-cell adhesion regulation of actin cytoskeleton reorganization uc009ouz.1 uc009ouz.2 uc009ouz.3 uc009ouz.4 
ENSMUST00000002013.11 Spa17 ENSMUST00000002013.11 sperm autoantigenic protein 17, transcript variant 1 (from RefSeq NM_011449.3) ENSMUST00000002013.1 ENSMUST00000002013.10 ENSMUST00000002013.2 ENSMUST00000002013.3 ENSMUST00000002013.4 ENSMUST00000002013.5 ENSMUST00000002013.6 ENSMUST00000002013.7 ENSMUST00000002013.8 ENSMUST00000002013.9 NM_011449 Q62252 SP17_MOUSE Sp17 uc009ovd.1 uc009ovd.2 uc009ovd.3 uc009ovd.4 Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity). Homodimer. May interact with ROPN1 (By similarity). Membrane ; Peripheral membrane protein Testis- and sperm-specific. calmodulin binding cytoplasm cilium binding of sperm to zona pellucida external side of plasma membrane membrane motile cilium sperm fibrous sheath sperm principal piece uc009ovd.1 uc009ovd.2 uc009ovd.3 uc009ovd.4 
ENSMUST00000002029.13 Emd ENSMUST00000002029.13 emerin, transcript variant 13 (from RefSeq NR_176956.1) EMD_MOUSE ENSMUST00000002029.1 ENSMUST00000002029.10 ENSMUST00000002029.11 ENSMUST00000002029.12 ENSMUST00000002029.2 ENSMUST00000002029.3 ENSMUST00000002029.4 ENSMUST00000002029.5 ENSMUST00000002029.6 ENSMUST00000002029.7 ENSMUST00000002029.8 ENSMUST00000002029.9 NR_176956 O08579 Q3TIH6 Q3UJP3 Sta uc009toa.1 uc009toa.2 uc009toa.3 uc009toa.4 Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta- catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1- dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non- farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells. Interacts with lamins A and C, BANF1, GMCL, BCLAF1 and YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the inner nuclear membrane. Interacts with ACTB, SPTAN1, F-actin, CTNNB1 and beta-tubulin (By similarity). Interacts with SUN1 and SUN2. Interacts with TMEM201. Interacts with NEMP1 (By similarity). Nucleus inner membrane ; Single-pass membrane protein; Nucleoplasmic side Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus (By similarity). In the ovary, highest expression is seen in primordial follicle oocytes (at protein level) (PubMed:32923640). Detected in embryonic fibroblasts, skeletal muscle, heart muscle and tongue epithelium (at protein level). Widely expressed. Early and highly significant depletion of primordial follicles. actin binding protein binding nucleus nuclear envelope nuclear inner membrane nuclear outer membrane nuclear lamina nucleoplasm cytoplasm endoplasmic reticulum spindle microtubule membrane integral component of membrane spindle pole centrosome nuclear membrane cortical endoplasmic reticulum skeletal muscle cell differentiation positive regulation of protein export from nucleus negative regulation of fibroblast proliferation beta-tubulin binding regulation of canonical Wnt signaling pathway cellular response to growth factor stimulus negative regulation of canonical Wnt signaling pathway uc009toa.1 uc009toa.2 uc009toa.3 uc009toa.4 
ENSMUST00000002043.10 Ccdc47 ENSMUST00000002043.10 coiled-coil domain containing 47 (from RefSeq NM_026009.2) Asp4 B1AR94 CCD47_MOUSE Ccdc47 ENSMUST00000002043.1 ENSMUST00000002043.2 ENSMUST00000002043.3 ENSMUST00000002043.4 ENSMUST00000002043.5 ENSMUST00000002043.6 ENSMUST00000002043.7 ENSMUST00000002043.8 ENSMUST00000002043.9 NM_026009 Q3TSB5 Q3V1S7 Q8C5D9 Q920S6 Q9D024 uc007lyi.1 uc007lyi.2 uc007lyi.3 uc007lyi.4 Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (By similarity). Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex (By similarity). Involved in the regulation of calcium ion homeostasis in the ER (By similarity). Required for proper protein degradation via the ERAD (ER- associated degradation) pathway (By similarity). Has an essential role in the maintenance of ER organization during embryogenesis (PubMed:25009997). Component of the PAT complex, composed of WDR83OS/Asterix and CCDC47 (By similarity). The PAT complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47) (By similarity). The MPT complex associates with the SEC61 complex (By similarity). Interacts with VCP, HSPA5, DERL1, DERL2 and SELENOS (PubMed:25009997). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Rough endoplasmic reticulum membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D024-1; Sequence=Displayed; Name=2; IsoId=Q9D024-2; Sequence=VSP_018480; Name=3; IsoId=Q9D024-3; Sequence=VSP_018479; In the embryo, expressed in the endodermal layer of the yolk sac and in the small intestine. CCDC47 knockout leads to embryonic lethality at mid-gestation, between 10.5 and 11.5 dpc. Mutant embryos at 8.5-10.5 dpc reveal several anomalies including vascular abnormalities in yolk sacs, developmental retardation, atrophic neural tubes, dilated left ventricles, poorly developed myocardium, and paucity of blood cells in the dorsal aorta. Yolk sac endoderm cells show alterations associated with endoplasmic reticulum stress, including lipid droplet accumulation, endoplasmic reticulum fragmentation and dissociation of ribosomes. Belongs to the CCDC47 family. calcium ion binding protein binding endoplasmic reticulum endoplasmic reticulum membrane rough endoplasmic reticulum ER overload response endoplasmic reticulum organization post-embryonic development membrane integral component of membrane ER-associated ubiquitin-dependent protein catabolic process rough endoplasmic reticulum membrane endoplasmic reticulum calcium ion homeostasis ERAD pathway calcium ion homeostasis uc007lyi.1 uc007lyi.2 uc007lyi.3 uc007lyi.4 
ENSMUST00000002044.10 Map3k3 ENSMUST00000002044.10 mitogen-activated protein kinase kinase kinase 3 (from RefSeq NM_011947.4) ENSMUST00000002044.1 ENSMUST00000002044.2 ENSMUST00000002044.3 ENSMUST00000002044.4 ENSMUST00000002044.5 ENSMUST00000002044.6 ENSMUST00000002044.7 ENSMUST00000002044.8 ENSMUST00000002044.9 M3K3_MOUSE Mekk3 NM_011947 Q61084 uc007lyc.1 uc007lyc.2 uc007lyc.3 uc007lyc.4 Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Activated by phosphorylation on Thr-530. Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex with MAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9. Q61084; Q9WVS7: Map2k5; NbExp=15; IntAct=EBI-446250, EBI-446144; Q61084; P70196: Traf6; NbExp=5; IntAct=EBI-446250, EBI-448028; Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. MAPK cascade nucleotide binding activation of MAPKK activity blood vessel development protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity protein binding ATP binding cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation activation of protein kinase activity intracellular signal transduction positive regulation of I-kappaB kinase/NF-kappaB signaling protein autophosphorylation metal ion binding positive regulation of cell proliferation in bone marrow positive regulation of cell migration involved in sprouting angiogenesis positive regulation of p38MAPK cascade negative regulation of cellular senescence uc007lyc.1 uc007lyc.2 uc007lyc.3 uc007lyc.4 
ENSMUST00000002048.8 Taco1 ENSMUST00000002048.8 translational activator of mitochondrially encoded cytochrome c oxidase I (from RefSeq NM_027346.2) B1AR86 Ccdc44 ENSMUST00000002048.1 ENSMUST00000002048.2 ENSMUST00000002048.3 ENSMUST00000002048.4 ENSMUST00000002048.5 ENSMUST00000002048.6 ENSMUST00000002048.7 NM_027346 Q3TI86 Q3USS8 Q8K0Z7 Q9CV09 TACO1_MOUSE uc007lyb.1 uc007lyb.2 uc007lyb.3 Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mitochondrion Belongs to the TACO1 family. molecular_function nucleus mitochondrion regulation of translation biological_process uc007lyb.1 uc007lyb.2 uc007lyb.3 
ENSMUST00000002053.9 Npas1 ENSMUST00000002053.9 neuronal PAS domain protein 1, transcript variant 1 (from RefSeq NM_008718.2) ENSMUST00000002053.1 ENSMUST00000002053.2 ENSMUST00000002053.3 ENSMUST00000002053.4 ENSMUST00000002053.5 ENSMUST00000002053.6 ENSMUST00000002053.7 ENSMUST00000002053.8 NM_008718 NPAS1_MOUSE P97459 uc009fhv.1 uc009fhv.2 uc009fhv.3 May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (PubMed:27782878). Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ARNT; forms a heterodimer that binds core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) leading to a transcriptional repressor on its target gene TH. Nucleus. Expressed in brain in inhibitory interneurons. Also found in spinal cord. First detected between embryonic day 15 and day 16. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding startle response DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter maternal behavior negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity uc009fhv.1 uc009fhv.2 uc009fhv.3 
ENSMUST00000002063.15 Ap4e1 ENSMUST00000002063.15 adaptor-related protein complex AP-4, epsilon 1 (from RefSeq NM_175550.3) A2ASB4 AP4E1_MOUSE Ap4e1 ENSMUST00000002063.1 ENSMUST00000002063.10 ENSMUST00000002063.11 ENSMUST00000002063.12 ENSMUST00000002063.13 ENSMUST00000002063.14 ENSMUST00000002063.2 ENSMUST00000002063.3 ENSMUST00000002063.4 ENSMUST00000002063.5 ENSMUST00000002063.6 ENSMUST00000002063.7 ENSMUST00000002063.8 ENSMUST00000002063.9 NM_175550 Q80V94 uc008men.1 uc008men.2 uc008men.3 Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal. Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1). Interacts with TEPSIN (By similarity). Interacts with GRIA2; probably indirect it mediates the somatodendritic localization of GRIA2 in neurons (PubMed:18341993). Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Belongs to the adaptor complexes large subunit family. Sequence=AK144636; Type=Frameshift; Evidence=; protein binding Golgi apparatus trans-Golgi network intracellular protein transport protein transport membrane vesicle-mediated transport membrane coat AP-4 adaptor complex uc008men.1 uc008men.2 uc008men.3 
ENSMUST00000002064.15 Blvra ENSMUST00000002064.15 biliverdin reductase A (from RefSeq NM_026678.4) BIEA_MOUSE Blvra ENSMUST00000002064.1 ENSMUST00000002064.10 ENSMUST00000002064.11 ENSMUST00000002064.12 ENSMUST00000002064.13 ENSMUST00000002064.14 ENSMUST00000002064.2 ENSMUST00000002064.3 ENSMUST00000002064.4 ENSMUST00000002064.5 ENSMUST00000002064.6 ENSMUST00000002064.7 ENSMUST00000002064.8 ENSMUST00000002064.9 NM_026678 Q3T9C6 Q80WR6 Q9CY64 Q9DD21 uc008meq.1 uc008meq.2 uc008meq.3 Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems. Reaction=bilirubin IXalpha + NAD(+) = biliverdin IXalpha + H(+) + NADH; Xref=Rhea:RHEA:15797, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57977, ChEBI:CHEBI:57991; EC=1.3.1.24; Evidence=; Reaction=bilirubin IXalpha + NADP(+) = biliverdin IXalpha + H(+) + NADPH; Xref=Rhea:RHEA:15793, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57977, ChEBI:CHEBI:57991, ChEBI:CHEBI:58349; EC=1.3.1.24; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Porphyrin-containing compound metabolism; protoheme degradation. Monomer. Cytoplasm, cytosol Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily. nucleotide binding biliverdin reductase activity cytoplasm cytosol zinc ion binding oxidoreductase activity heme catabolic process metal ion binding oxidation-reduction process uc008meq.1 uc008meq.2 uc008meq.3 
ENSMUST00000002073.13 Ltbp2 ENSMUST00000002073.13 latent transforming growth factor beta binding protein 2, transcript variant 1 (from RefSeq NM_001370743.1) E9QNQ3 E9QNQ3_MOUSE ENSMUST00000002073.1 ENSMUST00000002073.10 ENSMUST00000002073.11 ENSMUST00000002073.12 ENSMUST00000002073.2 ENSMUST00000002073.3 ENSMUST00000002073.4 ENSMUST00000002073.5 ENSMUST00000002073.6 ENSMUST00000002073.7 ENSMUST00000002073.8 ENSMUST00000002073.9 Ltbp2 NM_001370743 uc011ypc.1 uc011ypc.2 uc011ypc.3 Secreted, extracellular space, extracellular matrix Belongs to the LTBP family. Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding uc011ypc.1 uc011ypc.2 uc011ypc.3 
ENSMUST00000002079.7 Plxnb3 ENSMUST00000002079.7 plexin B3 (from RefSeq NM_019587.2) A2AFF9 ENSMUST00000002079.1 ENSMUST00000002079.2 ENSMUST00000002079.3 ENSMUST00000002079.4 ENSMUST00000002079.5 ENSMUST00000002079.6 Kiaa1206 NM_019587 PLXB3_MOUSE Plxn6 Q80TH8 Q9QY40 uc009tmn.1 uc009tmn.2 uc009tmn.3 uc009tmn.4 Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA- mediated inactivation of RAC1 (By similarity). Seem to be non-essential for normal development and function of the central nervous system. Binds MET and MST1R. Interacts with RIT2/RIN. May form homodimers (via Sema domain) (By similarity). Interacts (via cytoplasmic domain) with FSCN1, ARHGDIA and RAC1. Q9QY40; Q61553: Fscn1; NbExp=3; IntAct=EBI-6271317, EBI-2308857; Cell membrane ; Single-pass type I membrane protein Note=Colocalizes with RIT2/RIN at the plasma membrane. Expressed in brain (at protein level). In cerebellum, strongest expression detected in Purkinje and granular cells. Detected at very low levels in several fetal tissues, including dorsal root ganglia (DRG), heart, lung, optic bulb, brain and liver. In brain, detected first perinatally, with expression reaching maximal levels at postnatal day 9 (P9). In the developing nervous system, barely detectable until birth, and postnatally expressed in white matter tracks including the corpus callosum, external capsule, fimbria hippocampi and corticospinal tracts. In spinal cord, not detected until birth, and postnatally expressed in spinal white matter. In cerebellum, expressed only in cerebellar white matter cells, with expression detected first shortly after birth in the cerebellar peduncle and increasing progressively in the white matter tracts of the cerebellar lobes until P10. Mutant mice are viable and fertile and display no obvious morphological abnormalities in the brain or spinal cord. Belongs to the plexin family. Sequence=BAC65749.2; Type=Erroneous gene model prediction; Note=Contains intronic sequences.; Evidence=; positive regulation of endothelial cell proliferation semaphorin receptor complex protein binding plasma membrane integral component of plasma membrane homophilic cell adhesion via plasma membrane adhesion molecules negative regulation of cell adhesion signal transduction nervous system development regulation of cell shape cell surface negative regulation of lamellipodium assembly positive regulation of neuron projection development membrane integral component of membrane semaphorin receptor activity protein domain specific binding regulation of cell migration negative regulation of cell migration negative regulation of GTPase activity regulation of GTPase activity positive regulation of axonogenesis positive chemotaxis Rho GDP-dissociation inhibitor binding cell chemotaxis semaphorin-plexin signaling pathway protein binding involved in cell-cell adhesion semaphorin-plexin signaling pathway involved in axon guidance uc009tmn.1 uc009tmn.2 uc009tmn.3 uc009tmn.4 
ENSMUST00000002080.12 Pdzd4 ENSMUST00000002080.12 PDZ domain containing 4, transcript variant 1 (from RefSeq NM_001029868.2) A2AFG4 ENSMUST00000002080.1 ENSMUST00000002080.10 ENSMUST00000002080.11 ENSMUST00000002080.2 ENSMUST00000002080.3 ENSMUST00000002080.4 ENSMUST00000002080.5 ENSMUST00000002080.6 ENSMUST00000002080.7 ENSMUST00000002080.8 ENSMUST00000002080.9 NM_001029868 PDZD4_MOUSE Pdzk4 Pdzrn4l Q6PHP2 Q9QY39 Xlu uc009tmt.1 uc009tmt.2 uc009tmt.3 Cytoplasm, cell cortex Note=Mainly localized under the plasma membrane. Sequence=AAH56462.1; Type=Erroneous initiation; Evidence=; cytoplasm cell cortex protein ubiquitination ubiquitin protein ligase activity uc009tmt.1 uc009tmt.2 uc009tmt.3 
ENSMUST00000002081.6 Srpk3 ENSMUST00000002081.6 serine/arginine-rich protein specific kinase 3, transcript variant 2 (from RefSeq NM_019684.2) ENSMUST00000002081.1 ENSMUST00000002081.2 ENSMUST00000002081.3 ENSMUST00000002081.4 ENSMUST00000002081.5 Mssk1 NM_019684 Q9Z0G2 SRPK3_MOUSE Stk23 uc009tmo.1 uc009tmo.2 uc009tmo.3 uc009tmo.4 Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Exclusively expressed in skeletal and heart muscle. Expressed from embryogenesis to adulthood. Mice are viable to adulthood but display defects in skeletal muscle growth including reduced muscle mass, marked increase in centrally placed nuclei and disorganized intermyofibrillar network. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. nucleotide binding spliceosomal complex assembly protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation multicellular organism development muscle organ development skeletal muscle tissue development regulation of gene expression kinase activity phosphorylation transferase activity cell differentiation intracellular signal transduction regulation of mRNA processing muscle tissue development uc009tmo.1 uc009tmo.2 uc009tmo.3 uc009tmo.4 
ENSMUST00000002084.14 Abcd1 ENSMUST00000002084.14 ATP-binding cassette, sub-family D member 1 (from RefSeq NM_007435.2) ABCD1_MOUSE Abcd1 Ald Aldgh ENSMUST00000002084.1 ENSMUST00000002084.10 ENSMUST00000002084.11 ENSMUST00000002084.12 ENSMUST00000002084.13 ENSMUST00000002084.2 ENSMUST00000002084.3 ENSMUST00000002084.4 ENSMUST00000002084.5 ENSMUST00000002084.6 ENSMUST00000002084.7 ENSMUST00000002084.8 ENSMUST00000002084.9 NM_007435 P48410 Q9QY41 Q9QZ32 uc009tml.1 uc009tml.2 uc009tml.3 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in the human gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC079840.1, AK088792.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)- CoA from the cytosol to the peroxisome lumen. Has fatty acyl-CoA thioesterase (ACOT) and ATPase activities. Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (By similarity). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:9126326, PubMed:9418970, PubMed:9256488, PubMed:18854420, PubMed:23123468, PubMed:23604518, PubMed:25255441, PubMed:25583114, PubMed:26108493). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance (PubMed:11875044, PubMed:15489218, PubMed:26108493). Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization (PubMed:18344354, PubMed:22521832, PubMed:23604518, PubMed:25583114). And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (PubMed:18723473). Reaction=a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+); Xref=Rhea:RHEA:67072, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950, ChEBI:CHEBI:138261; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67073; Evidence=; Reaction=a very long-chain fatty acid(in) + ATP + H2O = a very long- chain fatty acid(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:67080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58950, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67081; Evidence=; Reaction=H2O + tetracosanoyl-CoA = CoA + H(+) + tetracosanoate; Xref=Rhea:RHEA:40787, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:31014, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40788; Evidence=; Reaction=ATP + H2O + tetracosanoate(in) = ADP + H(+) + phosphate + tetracosanoate(out); Xref=Rhea:RHEA:67088, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:31014, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Reaction=H2O + hexacosanoyl-CoA = CoA + H(+) + hexacosanoate; Xref=Rhea:RHEA:40791, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:31013, ChEBI:CHEBI:57287, ChEBI:CHEBI:64868; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40792; Evidence=; Reaction=ATP + H2O + hexacosanoate(in) = ADP + H(+) + hexacosanoate(out) + phosphate; Xref=Rhea:RHEA:67084, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:31013, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67085; Evidence=; Reaction=docosanoyl-CoA + H2O = CoA + docosanoate + H(+); Xref=Rhea:RHEA:40783, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:23858, ChEBI:CHEBI:57287, ChEBI:CHEBI:65059; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40784; Evidence=; Reaction=ATP + docosanoate(in) + H2O = ADP + docosanoate(out) + H(+) + phosphate; Xref=Rhea:RHEA:67092, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:23858, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Can form homodimers and heterodimers with ABCD2 and ABCD3 (PubMed:15276650). Dimerization is necessary to form an active transporter (By similarity). The minimal functional unit is a homodimer but the major oligomeric form in peroxisomal membrane is a homotetramer. Forms heterotramers with ABCD2 (By similarity). Interacts with PEX19; facilitates ABCD1 insertion into the peroxisome membrane (By similarity). P48410; P33897: ABCD1; Xeno; NbExp=2; IntAct=EBI-81118, EBI-81045; Peroxisome membrane ; Multi-pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Widely expressed at low levels with higher levels in heart, lung, intestine and spleen than in skeletal muscle, brain, liver and kidney. Most abundant in embryo. Gradually decreases during maturation. By dietary fenofibrate. The NH2-terminal transmembrane domaine (TMD) is involved in the recognition of substrates, and undergoes a conformational change upon ATP binding to the COOH-terminal nucleotide binding domain (NBD). Tyrosine-phosphorylated. Abcd1 hemizygous males are viable and apparently healthy and they show no detectable motor defect for at least 4-month- old. Inbreeding homozygous and hemizygous Abcd1-deficient mice show a reduction of fertility. Moreover, among several 6-month-old mice, there is at least one apparently infertile mutant of each sex. The infertile hemizygous male show additionally a severe testicular atrophy (PubMed:9418970). Abcd1 hemizygous mutant male and homozygous mutant mice grow normally, are fer- tile, and appear normal at least up to one year of age (PubMed:9126326). Abcd1 hemizygous mutant male and homozygous mutant mice grow normally, are fer- tile, and appear normal at least up to 6 months of age (PubMed:9256488). At 20 months of age, Abcd1 homozygous mice present an impairment of their locomotor coordination and exploratory abilities (PubMed:11875044, PubMed:15489218). Double Abcd1 and Abcd2 knockout mice exhibit severe impairment of their locomotor coordination and exploratory abilities already at 15 months of age (PubMed:15489218). Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. very long-chain fatty acid metabolic process nucleotide binding regulation of oxidative phosphorylation long-chain fatty acid transporter activity protein binding ATP binding cytoplasm mitochondrion lysosome lysosomal membrane peroxisome peroxisomal membrane integral component of peroxisomal membrane endoplasmic reticulum endoplasmic reticulum membrane fatty acid beta-oxidation peroxisome organization fatty-acyl-CoA transporter activity peroxisomal long-chain fatty acid import fatty-acyl-CoA transport membrane integral component of membrane ATPase activity enzyme binding fatty acid elongation mitochondrial membrane regulation of fatty acid beta-oxidation positive regulation of fatty acid beta-oxidation very long-chain fatty-acyl-CoA catabolic process ATPase activity, coupled to transmembrane movement of substances long-chain fatty acid catabolic process very long-chain fatty acid catabolic process identical protein binding protein homodimerization activity myelin maintenance ADP binding perinuclear region of cytoplasm regulation of mitochondrial depolarization transmembrane transport fatty acid homeostasis sterol homeostasis negative regulation of cytokine production involved in inflammatory response regulation of cellular response to oxidative stress negative regulation of reactive oxygen species biosynthetic process neuron projection maintenance positive regulation of unsaturated fatty acid biosynthetic process uc009tml.1 uc009tml.2 uc009tml.3 
ENSMUST00000002090.3 Ssr4 ENSMUST00000002090.3 signal sequence receptor, delta, transcript variant 2 (from RefSeq NM_009279.5) ENSMUST00000002090.1 ENSMUST00000002090.2 NM_009279 Q62186 SSRD_MOUSE uc009tmr.1 uc009tmr.2 uc009tmr.3 uc009tmr.4 TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP- gamma. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Belongs to the TRAP-delta family. molecular_function endoplasmic reticulum Sec61 translocon complex endoplasmic reticulum membrane biological_process membrane integral component of membrane uc009tmr.1 uc009tmr.2 uc009tmr.3 uc009tmr.4 
ENSMUST00000002091.6 Bcap31 ENSMUST00000002091.6 B cell receptor associated protein 31, transcript variant 1 (from RefSeq NM_012060.6) A2ALM8 BAP31_MOUSE Bap31 ENSMUST00000002091.1 ENSMUST00000002091.2 ENSMUST00000002091.3 ENSMUST00000002091.4 ENSMUST00000002091.5 NM_012060 Q61335 Q9D0E9 Q9D8G7 uc009tmj.1 uc009tmj.2 uc009tmj.3 uc009tmj.4 Functions as a chaperone protein (PubMed:9396746). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:9396746). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:9396746). Also serves as a cargo receptor for the export of transmembrane proteins (PubMed:15187134). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (By similarity). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (By similarity). May be involved in CASP8-mediated apoptosis (By similarity). Homodimer and heterodimer with BCAP29 (PubMed:8612576). Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1 (By similarity). Forms a complex (via C-terminus) with TOMM40 which mediates the translocation of components of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) from the cytosol to the mitochondria; within the complex BCAP31 interacts directly with unprocessed and processed NDUFS4 and NDUFB11. Interacts with VDAC1 (By similarity). Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins (PubMed:9396746). Interacts with HACD2 (By similarity). Interacts with DNM1L; may form part of a larger protein complex at the endoplasmic reticulum-mitochondrial interface during mitochondrial fission (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Note=May shuttle between the ER and the intermediate compartment/cis-Golgi complex. Associates with the mitochondria- associated endoplasmic reticulum membrane via interaction with TOMM40. Ubiquitous. Cleaved by CASP8 and other caspases. Belongs to the BCAP29/BCAP31 family. Golgi membrane protein binding mitochondrion endoplasmic reticulum endoplasmic reticulum membrane lipid particle integral component of plasma membrane intracellular protein transport ER to Golgi vesicle-mediated transport apoptotic process positive regulation of cytosolic calcium ion concentration spermatogenesis protein transport membrane integral component of membrane vesicle-mediated transport clathrin-coated vesicle negative regulation of endoplasmic reticulum calcium ion concentration Golgi cisterna membrane endoplasmic reticulum-Golgi intermediate compartment membrane calcium-mediated signaling using intracellular calcium source MHC class I protein binding positive regulation of cysteine-type endopeptidase activity involved in apoptotic process macromolecular complex binding positive regulation of mitochondrial calcium ion concentration protein localization to endoplasmic reticulum exit site perinuclear endoplasmic reticulum positive regulation of ER-associated ubiquitin-dependent protein catabolic process positive regulation of retrograde protein transport, ER to cytosol positive regulation of intrinsic apoptotic signaling pathway uc009tmj.1 uc009tmj.2 uc009tmj.3 uc009tmj.4 
ENSMUST00000002095.11 Kmt2a ENSMUST00000002095.11 Histone methyltransferase that plays an essential role in early development and hematopoiesis (By similarity). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (By similarity). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (By similarity). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (By similarity). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (By similarity). Required for transcriptional activation of HOXA9 (By similarity). Promotes PPP1R15A-induced apoptosis (By similarity). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (PubMed:21113167). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (PubMed:21113167). Also has auto-methylation activity on Cys-3879 in absence of histone H3 substrate (By similarity). (from UniProt P55200) All1 E9QNE7 ENSMUST00000002095.1 ENSMUST00000002095.10 ENSMUST00000002095.2 ENSMUST00000002095.3 ENSMUST00000002095.4 ENSMUST00000002095.5 ENSMUST00000002095.6 ENSMUST00000002095.7 ENSMUST00000002095.8 ENSMUST00000002095.9 Hrx KMT2A_MOUSE L17069 Mll Mll1 P55200 Q3UEU1 Q3USE7 uc009pep.1 uc009pep.2 uc009pep.3 Histone methyltransferase that plays an essential role in early development and hematopoiesis (By similarity). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (By similarity). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (By similarity). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (By similarity). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (By similarity). Required for transcriptional activation of HOXA9 (By similarity). Promotes PPP1R15A-induced apoptosis (By similarity). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (PubMed:21113167). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (PubMed:21113167). Also has auto-methylation activity on Cys-3879 in absence of histone H3 substrate (By similarity). Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265; Evidence=; Reaction=N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60268, Rhea:RHEA-COMP:15540, Rhea:RHEA- COMP:15543, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60269; Evidence=; Reaction=L-cysteinyl-[protein] + S-adenosyl-L-methionine = H(+) + S- adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:66544, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:10132, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:82612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66545; Evidence=; MLL cleavage product N320 heterodimerizes with MLL cleavage product C180 (via SET and FYRC domains). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, HCFC2, WDR5, DPY30 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts (via WIN motif) with WDR5; the interaction is direct. Interaction with WDR5 is required for stable interaction with ASH2L and RBBP5, and thereby also for optimal histone methyltransferase activity. Interacts with KAT8/MOF; the interaction is direct. Interacts with SBF1 and PPP1R15A. Interacts with ZNF335 (By similarity). Interacts with CLOCK and BMAL1 in a circadian manner (PubMed:21113167). Interacts with PPIE; this results in decreased histone H3 methyltransferase activity. Interacts with CREBBP (By similarity). Interacts with the WRAD complex composed of WDR5, RBBP5, ASH2L and DPY30 (By similarity). Interacts (via MBM motif) with MEN1 (By similarity). Interacts (via IBM motifs) with PSIP1 (via IBD domain) with moderate affinity whereas the KMT2A- MEN1 complex interacts with a greater affinity; MEN1 enhances interaction of KMT2A with PSIP1 (By similarity). Phosphorylation increases its affinity for PSIP1 (By similarity). Forms a complex with CREBBP and CREB1 (By similarity). Nucleus [MLL cleavage product N320]: Nucleus [MLL cleavage product C180]: Nucleus Note=Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55200-1; Sequence=Displayed; Name=2; IsoId=P55200-2; Sequence=VSP_006667; The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. The SET domain structure is atypical and is not in an optimal position to have methyltransferase activity. It requires other components of the MLL1/MLL complex, such as ASH2L or RBBP5, to order the active site and obtain optimal histone methyltransferase activity. The CXXC-type zinc finger binds to DNA sequence elements containing unmethylated CpG dinucleotides. The third PHD-type zinc-finger binds both trimethylated histone H3K4me3 and PPIE; histone and PPIE bind to distinct surfaces. Nevertheless, PPIE binding and histone binding are mutually inhibitory. Isomerization of a peptidylproline bond in the linker between the third PHD-type zinc-finger and the bromo domain disrupts the interaction between the bromo domain and the third PHD-type zinc-finger, and thereby facilitates interaction with PPIE. Proteolytic cleavage by TASP1 generates MLL cleavage 3product N320 and MLL cleavage product C180, which reassemble through a non-covalent association. 2 cleavage sites exist, cleavage site 1 (CS1) and cleavage site 2 (CS2), to generate MLL cleavage products N320 and C180. CS2 is the major site. Phosphorylation increases its interaction with PSIP1. Auto-methylated at Cys-3879: auto-methylation is inhibited by the WRAD complex and unmodified histone H3. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. Sequence=BAE24386.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; RNA polymerase II distal enhancer sequence-specific DNA binding DNA binding chromatin binding protein binding nucleus nucleoplasm cytosol DNA methylation chromatin organization regulation of transcription, DNA-templated methyltransferase activity zinc ion binding negative regulation of cell proliferation visual learning response to light stimulus post-embryonic development anterior/posterior pattern specification regulation of gene expression transferase activity histone-lysine N-methyltransferase activity peptidyl-lysine monomethylation methylation positive regulation of transporter activity circadian regulation of gene expression histone methyltransferase complex embryonic hemopoiesis exploration behavior response to potassium ion histone methyltransferase activity (H3-K4 specific) identical protein binding protein homodimerization activity histone H4-K16 acetylation transcription regulatory region DNA binding histone H3-K4 dimethylation unmethylated CpG binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding regulation of short-term neuronal synaptic plasticity rhythmic process spleen development homeostasis of number of cells within a tissue cognition histone H3-K4 methylation regulation of histone H3-K4 methylation positive regulation of histone H3-K4 methylation membrane depolarization definitive hemopoiesis macromolecular complex assembly lysine-acetylated histone binding MLL1 complex regulation of histone H3-K14 acetylation histone H3-K4 trimethylation regulation of histone H3-K27 acetylation negative regulation of DNA methylation regulation of histone H3-K9 acetylation positive regulation of cellular response to drug uc009pep.1 uc009pep.2 uc009pep.3 
ENSMUST00000002099.11 Ift46 ENSMUST00000002099.11 Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis. (from UniProt Q9DB07) AK032880 ENSMUST00000002099.1 ENSMUST00000002099.10 ENSMUST00000002099.2 ENSMUST00000002099.3 ENSMUST00000002099.4 ENSMUST00000002099.5 ENSMUST00000002099.6 ENSMUST00000002099.7 ENSMUST00000002099.8 ENSMUST00000002099.9 IFT46_MOUSE Q91Z06 Q9DB07 Q9JHT1 uc009pek.1 uc009pek.2 uc009pek.3 Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis. Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT57, IFT88 and DAW1. Interacts with ARL13B. Interacts with IFT56. Interacts with TTC25 (PubMed:25860617). Interacts with IFT70B (PubMed:23810713). Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Note=Expression is concentrated at the cilium basal body but is also detected along the length of the cilium. Strongly expressed in ovary and testis, moderately expressed in kidney and brain, and weakly expressed in thymus, heart, lung, liver, spleen and muscle. Expressed in embryonic bone and cartilage, with high expression in non-hypertrophic chondrocytes and weaker expression in hypertrophic chondrocytes. Expressed from 8 dpc throughout embryonic development, with levels increasing at 12.5 dpc and remaining constant thereafter. Up-regulated during chondrocyte maturation and skeletogenesis. By BMP2. Short cilia. Belongs to the IFT46 family. protein binding cytoplasm centrosome cytoskeleton cilium smoothened signaling pathway protein transport intraciliary transport particle B motile cilium regulation of protein stability axoneme assembly intraciliary transport cell projection cilium organization ciliary membrane cilium assembly cilium-dependent cell motility ciliary base regulation of cilium assembly uc009pek.1 uc009pek.2 uc009pek.3 
ENSMUST00000002100.8 Tmem25 ENSMUST00000002100.8 transmembrane protein 25, transcript variant 2 (from RefSeq NM_027865.3) ENSMUST00000002100.1 ENSMUST00000002100.2 ENSMUST00000002100.3 ENSMUST00000002100.4 ENSMUST00000002100.5 ENSMUST00000002100.6 ENSMUST00000002100.7 NM_027865 Q3TMP3 Q6PAK7 Q9DCF1 TMM25_MOUSE Tmem25 uc009pem.1 uc009pem.2 uc009pem.3 In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. Interacts with GRIN2B. Late endosome Lysosome [Isoform 1]: Cell membrane ; Single- pass type I membrane protein [Isoform 2]: Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DCF1-1; Sequence=Displayed; Name=2; IsoId=Q9DCF1-2; Sequence=VSP_012942; Expressed throughout the brain with higher levels within the hippocampus. molecular_function cellular_component extracellular region plasma membrane biological_process membrane integral component of membrane uc009pem.1 uc009pem.2 uc009pem.3 
ENSMUST00000002101.12 Cd3g ENSMUST00000002101.12 CD3 antigen, gamma polypeptide (from RefSeq NM_009850.2) Cd3g ENSMUST00000002101.1 ENSMUST00000002101.10 ENSMUST00000002101.11 ENSMUST00000002101.2 ENSMUST00000002101.3 ENSMUST00000002101.4 ENSMUST00000002101.5 ENSMUST00000002101.6 ENSMUST00000002101.7 ENSMUST00000002101.8 ENSMUST00000002101.9 NM_009850 Q3U4Y3 Q3U4Y3_MOUSE uc009pex.1 uc009pex.2 uc009pex.3 The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. transmembrane signaling receptor activity establishment or maintenance of cell polarity cell surface receptor signaling pathway protein transport membrane integral component of membrane protein homodimerization activity protein heterodimerization activity protein homooligomerization regulation of lymphocyte apoptotic process uc009pex.1 uc009pex.2 uc009pex.3 
ENSMUST00000002112.15 Trappc6a ENSMUST00000002112.15 trafficking protein particle complex 6A, transcript variant 1 (from RefSeq NM_025960.4) ENSMUST00000002112.1 ENSMUST00000002112.10 ENSMUST00000002112.11 ENSMUST00000002112.12 ENSMUST00000002112.13 ENSMUST00000002112.14 ENSMUST00000002112.2 ENSMUST00000002112.3 ENSMUST00000002112.4 ENSMUST00000002112.5 ENSMUST00000002112.6 ENSMUST00000002112.7 ENSMUST00000002112.8 ENSMUST00000002112.9 NM_025960 Q3KQP0 Q78XR0 Q8C2C8 Q9CQ27 Q9D8H6 TPC6A_MOUSE Trappc6a uc009fmc.1 uc009fmc.2 uc009fmc.3 May play a role in vesicular transport during the biogenesis of melanosomes. Part of the multisubunit transport protein particle (TRAPP) complex. Heterodimer with TRAPPC3 (By similarity). The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L. Interacts with TRAPPC2L (By similarity). Golgi apparatus, cis-Golgi network Endoplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q78XR0-1; Sequence=Displayed; Name=2; IsoId=Q78XR0-2; Sequence=VSP_019586; Ubiquitous, with lowest expression in skeletal muscle and brain and highest in kidney, liver and testis, as well as in cultured melanocytes. Belongs to the TRAPP small subunits family. BET3 subfamily. endoplasmic reticulum Golgi apparatus cis-Golgi network trans-Golgi network ER to Golgi vesicle-mediated transport vesicle-mediated transport regulation of GTPase activity pigmentation Golgi vesicle transport melanosome assembly uc009fmc.1 uc009fmc.2 uc009fmc.3 
ENSMUST00000002121.5 Supt6 ENSMUST00000002121.5 SPT6, histone chaperone and transcription elongation factor (from RefSeq NM_009297.2) ENSMUST00000002121.1 ENSMUST00000002121.2 ENSMUST00000002121.3 ENSMUST00000002121.4 Kiaa0162 NM_009297 Q5SYM0 Q62383 Q6GQS3 Q6ZQI0 Q8BQY6 SPT6H_MOUSE Supt6h uc007kip.1 uc007kip.2 uc007kip.3 uc007kip.4 Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C- terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation- coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. Interacts with RNA polymerase II and the DRB sensitivity- inducing factor complex (DSIF complex), which is composed of SUPT5H and SUPT4H1 or SUPT4H2 (By similarity). Interacts with PAAF1 (By similarity). Interacts with histone H2B and H3 (By similarity). Interacts (via SH2 domain) with POLR2A phosphorylated at 'Ser-2'. Interacts (via SH2 domain) with SETD1A. Interacts with IWS1, KDM6A and AICDA. Interacts with WDR43 (PubMed:31128943). Nucleus Ubiquitously expressed. Belongs to the SPT6 family. blastocyst formation nucleic acid binding DNA binding protein binding nucleus nucleobase-containing compound metabolic process transcription elongation from RNA polymerase II promoter mRNA processing transcription elongation factor complex RNA splicing regulation of mRNA export from nucleus nucleosome binding positive regulation of transcription elongation from RNA polymerase II promoter nucleosome organization transcriptionally active chromatin histone binding mRNA transcription from RNA polymerase II promoter regulation of isotype switching regulation of mRNA processing mRNA transport regulation of muscle cell differentiation negative regulation of histone H3-K27 methylation chromatin maintenance uc007kip.1 uc007kip.2 uc007kip.3 uc007kip.4 
ENSMUST00000002127.14 Unc119 ENSMUST00000002127.14 unc-119 lipid binding chaperone, transcript variant 2 (from RefSeq NM_011676.3) ENSMUST00000002127.1 ENSMUST00000002127.10 ENSMUST00000002127.11 ENSMUST00000002127.12 ENSMUST00000002127.13 ENSMUST00000002127.2 ENSMUST00000002127.3 ENSMUST00000002127.4 ENSMUST00000002127.5 ENSMUST00000002127.6 ENSMUST00000002127.7 ENSMUST00000002127.8 ENSMUST00000002127.9 NM_011676 Q9Z2R6 U119A_MOUSE Unc119h uc007kjb.1 uc007kjb.2 uc007kjb.3 uc007kjb.4 The protein encoded by this gene is multifunctional, affecting trafficking of transducin in rod photoreceptors, interacting with src-type tyrosine kinases through SH2 and SH3 interacting domains, and aiding the uptake of bacteria through endocytosis. In addition, the encoded protein acts as a lipid-binding chaperone to help localize some myristoylated proteins correctly. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons (PubMed:21642972). Probably plays a role in trafficking proteins in photoreceptor cells (PubMed:17174953). Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A. May interact with GTP-bound ARL1. Interacts with ARL2 and ARL3 (GTP-bound forms); this promotes the release of myristoylated cargo proteins (By similarity). Found in a complex with ARL3, RP2 and UNC119; RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119. Interacts with NPHP3 (when myristoylated). Interacts with CYS1 (when myristoylated). Interacts with MACIR; interaction only takes place when UNC119 is not liganded with myristoylated proteins (By similarity). Interacts with CABP4; in the absence of calcium. Interacts with DNM1; leading to a decrease of DNM1 GTPase activity. Interacts with LCK; this interaction plays a crucial role in activation of LCK (By similarity). Interacts with FYN (By similarity). Interacts with RAB11A; in a cell cycle-dependent manner (By similarity). Interacts with LYN (via SH2 and SH3 domains); leading to LYN activation (By similarity). Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases. Interacts with CD44 (By similarity). Interacts with KLHL18 (via kelch repeats). Interacts with PPP3CA, PPP3CB and PPP3CC (PubMed:31696965). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=ocalizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells. Localized in photoreceptor synapses in the outer plexiform layer of the retina. Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that captures N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (By similarity). Phosphorylation suppresses its interaction with KLHL18 and down- regulates its KLHL18-mediated degradation (PubMed:31696965). Phosphorylated more under light conditions than dark conditions (PubMed:31696965). Dephosphorylated by calcineurin (PubMed:31696965). Mice develop a slowly progressive retinal degeneration, characterized by mottling in the fundus, mild thinning of the photoreceptor layer, and increase in apoptosis as early as 6 months, dramatic acceleration at approximately 17 months, and virtual obliteration of the photoreceptors by 20 months. Phenotypes are due to defects in protein trafficking, such as Gnat1 mislocalization. Belongs to the PDE6D/unc-119 family. mitotic cytokinesis spindle pole protein binding cytoplasm centrosome microtubule organizing center spindle cytoskeleton endocytosis nervous system development visual perception lipid binding protein transport lipoprotein transport intercellular bridge response to stimulus spindle midzone positive regulation of protein tyrosine kinase activity negative regulation of clathrin-dependent endocytosis negative regulation of caveolin-mediated endocytosis uc007kjb.1 uc007kjb.2 uc007kjb.3 uc007kjb.4 
ENSMUST00000002128.14 Rab34 ENSMUST00000002128.14 RAB34, member RAS oncogene family, transcript variant 2 (from RefSeq NM_001159482.1) ENSMUST00000002128.1 ENSMUST00000002128.10 ENSMUST00000002128.11 ENSMUST00000002128.12 ENSMUST00000002128.13 ENSMUST00000002128.2 ENSMUST00000002128.3 ENSMUST00000002128.4 ENSMUST00000002128.5 ENSMUST00000002128.6 ENSMUST00000002128.7 ENSMUST00000002128.8 ENSMUST00000002128.9 NM_001159482 Q0PD20 Q0PD20_MOUSE Rab34 uc011yai.1 uc011yai.2 uc011yai.3 GTPase activity GTP binding uc011yai.1 uc011yai.2 uc011yai.3 
ENSMUST00000002133.9 Sdf2 ENSMUST00000002133.9 stromal cell derived factor 2, transcript variant 1 (from RefSeq NM_009143.4) ENSMUST00000002133.1 ENSMUST00000002133.2 ENSMUST00000002133.3 ENSMUST00000002133.4 ENSMUST00000002133.5 ENSMUST00000002133.6 ENSMUST00000002133.7 ENSMUST00000002133.8 NM_009143 P97307 Q9DCT5 SDF2_MOUSE uc007kiq.1 uc007kiq.2 uc007kiq.3 Secreted. Ubiquitously expressed with highest expression in liver and kidney. Sequence=BAB22144.2; Type=Erroneous initiation; Evidence=; dolichyl-phosphate-mannose-protein mannosyltransferase activity extracellular region endoplasmic reticulum membrane membrane protein O-linked mannosylation uc007kiq.1 uc007kiq.2 uc007kiq.3 
ENSMUST00000002152.13 Bbc3 ENSMUST00000002152.13 BCL2 binding component 3, transcript variant 1 (from RefSeq NM_133234.3) BBC3_MOUSE ENSMUST00000002152.1 ENSMUST00000002152.10 ENSMUST00000002152.11 ENSMUST00000002152.12 ENSMUST00000002152.2 ENSMUST00000002152.3 ENSMUST00000002152.4 ENSMUST00000002152.5 ENSMUST00000002152.6 ENSMUST00000002152.7 ENSMUST00000002152.8 ENSMUST00000002152.9 NM_133234 Puma Q99ML1 uc009fho.1 uc009fho.2 uc009fho.3 uc009fho.4 Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis (By similarity). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (By similarity). Regulates ER stress- induced neuronal apoptosis (PubMed:21159964, PubMed:22761832). Interacts with MCL1 and BCL2A1 (PubMed:18589438, PubMed:18462686). Interacts with BCL2 and BCL2L1/BCL-XL (By similarity). Interacts (via BH3 domain) with NOL3 (via CARD domain); this interaction prevents BBC3 association with BCL2 and results in CASP8 activation (By similarity). Q99ML1; Q07440: Bcl2a1; NbExp=2; IntAct=EBI-727801, EBI-707754; Q99ML1; P97287: Mcl1; NbExp=2; IntAct=EBI-727801, EBI-707292; Q99ML1; Q07817-1: BCL2L1; Xeno; NbExp=3; IntAct=EBI-727801, EBI-287195; Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release. By DNA damage, glucocorticoid treatment, growth factor deprivation and p53 (By similarity). By ER stress in a DDIT3/CHOP- dependent manner. The BH3 motif is intrinsically disordered in the absence of a binding partner but folds upon binding (PubMed:18589438). Folds when bound to BCL2L1 (By similarity). Also folds when bound to MCL1 (PubMed:18589438). Belongs to the Bcl-2 family. release of cytochrome c from mitochondria protein binding mitochondrion mitochondrial envelope endoplasmic reticulum apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus determination of adult lifespan negative regulation of cell growth positive regulation of protein homooligomerization negative regulation of endoplasmic reticulum calcium ion concentration response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic process positive regulation of neuron apoptotic process negative regulation of growth ATPase binding release of sequestered calcium ion into cytosol intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of thymocyte apoptotic process cellular response to ionizing radiation intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of release of cytochrome c from mitochondria apoptotic signaling pathway intrinsic apoptotic signaling pathway execution phase of apoptosis positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway toxin transport positive regulation of cysteine-type endopeptidase activity positive regulation of intrinsic apoptotic signaling pathway lysosome uc009fho.1 uc009fho.2 uc009fho.3 uc009fho.4 
ENSMUST00000002172.14 Acp2 ENSMUST00000002172.14 Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2; (from UniProt P24638) AK170658 ENSMUST00000002172.1 ENSMUST00000002172.10 ENSMUST00000002172.11 ENSMUST00000002172.12 ENSMUST00000002172.13 ENSMUST00000002172.2 ENSMUST00000002172.3 ENSMUST00000002172.4 ENSMUST00000002172.5 ENSMUST00000002172.6 ENSMUST00000002172.7 ENSMUST00000002172.8 ENSMUST00000002172.9 P24638 PPAL_MOUSE Q8QZT5 uc008kvf.1 uc008kvf.2 uc008kvf.3 uc008kvf.4 Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2; Lysosome membrane ; Single-pass membrane protein ; Lumenal side Lysosome lumen Note=The soluble form arises by proteolytic processing of the membrane-bound form. The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen (By similarity). Belongs to the histidine acid phosphatase family. skeletal system development phosphotyrosine binding acid phosphatase activity phosphoprotein phosphatase activity lysosome lysosomal membrane protein dephosphorylation lysosome organization response to organic substance membrane integral component of membrane dephosphorylation hydrolase activity cytoplasmic vesicle neuron projection lysosomal lumen autophagic cell death uc008kvf.1 uc008kvf.2 uc008kvf.3 uc008kvf.4 
ENSMUST00000002180.8 Spi1 ENSMUST00000002180.8 spleen focus forming virus (SFFV) proviral integration oncogene, transcript variant 2 (from RefSeq NM_011355.2) ENSMUST00000002180.1 ENSMUST00000002180.2 ENSMUST00000002180.3 ENSMUST00000002180.4 ENSMUST00000002180.5 ENSMUST00000002180.6 ENSMUST00000002180.7 NM_011355 Q3U5L4 Q3U5L4_MOUSE Sfpi1 Spi1 uc008kuj.1 uc008kuj.2 uc008kuj.3 uc008kuj.4 Nucleus Belongs to the ETS family. nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated transcription factor binding sequence-specific DNA binding histone H3 acetylation hypermethylation of CpG island regulation of erythrocyte differentiation negative regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter pri-miRNA transcription from RNA polymerase II promoter interleukin-6-mediated signaling pathway cellular response to ethanol negative regulation of histone H4 acetylation uc008kuj.1 uc008kuj.2 uc008kuj.3 uc008kuj.4 
ENSMUST00000002198.4 Sf3a1 ENSMUST00000002198.4 splicing factor 3a, subunit 1 (from RefSeq NM_026175.5) ENSMUST00000002198.1 ENSMUST00000002198.2 ENSMUST00000002198.3 NM_026175 Q8C0M7 Q8C128 Q8C175 Q8K4Z5 Q921T3 SF3A1_MOUSE uc007hup.1 uc007hup.2 uc007hup.3 uc007hup.4 Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre- mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre- catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes. Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Part of the SF3A subcomplex of the 17S U2 SnRNP complex which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62 and SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the mature 17S U2 small nuclear ribonucleoprotein complex (17S U2 snRNP). SF3A1 functions as a scaffold that interacts directly with both SF3A2 and SF3A3. Identified in the spliceosome 'E' complex, a precursor of the spliceosome 'A' complex. Identified in the spliceosome 'A' and 'B' complexes. Identified in the spliceosome 'C' complex. Nucleus Nucleus speckle SURP motif 2 mediates direct binding to SF3A3. mRNA splicing, via spliceosome RNA binding nucleus spliceosomal complex U2-type spliceosomal complex U2 snRNP RNA processing mRNA processing RNA splicing nuclear speck U2-type prespliceosome U2-type precatalytic spliceosome catalytic step 2 spliceosome U2-type prespliceosome assembly uc007hup.1 uc007hup.2 uc007hup.3 uc007hup.4 
ENSMUST00000002259.13 Clgn ENSMUST00000002259.13 calmegin, transcript variant 1 (from RefSeq NM_009904.4) CLGN_MOUSE ENSMUST00000002259.1 ENSMUST00000002259.10 ENSMUST00000002259.11 ENSMUST00000002259.12 ENSMUST00000002259.2 ENSMUST00000002259.3 ENSMUST00000002259.4 ENSMUST00000002259.5 ENSMUST00000002259.6 ENSMUST00000002259.7 ENSMUST00000002259.8 ENSMUST00000002259.9 Meg1 NM_009904 P52194 Q80YU3 Q9D2K5 uc009mkd.1 uc009mkd.2 uc009mkd.3 uc009mkd.4 This gene belongs to the calreticulin family, which includes calreticulin, calnexin, and calmegin, and encodes a calcium-binding molecular chaperone specifically expressed in pachytene stage male germ cells. It is required for the proper folding of newly synthesized membrane proteins in the endoplasmic reticulum including those critical for sperm migration from the uterus into the oviduct and sperm adhesion to and penetration of the zona pellucida. This gene plays a key role in spermatogenesis and male infertility. Alternative splice variants exist for this gene. [provided by RefSeq, Jul 2016]. Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions. Interacts with PDILT and PPIB (By similarity). Interacts with ADAM2. Interacts with ADAM1A, ADAM1B and ADAM3; these are protein- coding genes in mouse but may be pseudogenes in other organisms. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Detected in testis (at protein level). Detected in testis. Specifically expressed during male meiotic germ cell development. First detected in early pachytene spermatocytes. Expression is highest in elongating and round spermatids and decreases thereafter. Not detectable in mature spermatids. Male mice show normal mating behavior and produce morphologically normal sperm, but are nearly sterile. Mutant sperm fail to adhere to the egg zona pellucida and are generally unable to penetrate the egg extracellular matrix. In addition, mutant sperm display defects in migration from the uterus into the oviduct. Belongs to the calreticulin family. calcium ion binding protein binding nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane protein folding multicellular organism development spermatogenesis single fertilization binding of sperm to zona pellucida membrane integral component of membrane cell differentiation endoplasmic reticulum unfolded protein response protein binding involved in protein folding unfolded protein binding meiotic cell cycle macromolecular complex assembly uc009mkd.1 uc009mkd.2 uc009mkd.3 uc009mkd.4 
ENSMUST00000002274.10 Napsa ENSMUST00000002274.10 napsin A aspartic peptidase (from RefSeq NM_008437.1) ENSMUST00000002274.1 ENSMUST00000002274.2 ENSMUST00000002274.3 ENSMUST00000002274.4 ENSMUST00000002274.5 ENSMUST00000002274.6 ENSMUST00000002274.7 ENSMUST00000002274.8 ENSMUST00000002274.9 NM_008437 Napsa Q3U7H1 Q3U7H1_MOUSE uc009gqf.1 uc009gqf.2 uc009gqf.3 Belongs to the peptidase A1 family. endopeptidase activity aspartic-type endopeptidase activity extracellular space lysosome proteolysis peptidase activity hydrolase activity membrane protein proteolysis surfactant homeostasis alveolar lamellar body uc009gqf.1 uc009gqf.2 uc009gqf.3 
ENSMUST00000002275.15 Vrk3 ENSMUST00000002275.15 vaccinia related kinase 3, transcript variant 11 (from RefSeq NR_185026.1) ENSMUST00000002275.1 ENSMUST00000002275.10 ENSMUST00000002275.11 ENSMUST00000002275.12 ENSMUST00000002275.13 ENSMUST00000002275.14 ENSMUST00000002275.2 ENSMUST00000002275.3 ENSMUST00000002275.4 ENSMUST00000002275.5 ENSMUST00000002275.6 ENSMUST00000002275.7 ENSMUST00000002275.8 ENSMUST00000002275.9 NR_185026 Q8K3G5 Q921W6 VRK3_MOUSE uc009gqr.1 uc009gqr.2 uc009gqr.3 uc009gqr.4 Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. Interacts with DUSP3. Interacts with RAN (By similarity). Nucleus Expressed in liver, kidney, muscle, thymus, and bone marrow. Weakly expressed in spleen. Weakly expressed in embryo compared to VRK1 and VRK3. Expressed from 10.5 dpc to 13.5 dpc in developing liver and then decreases. It increases again from 17.5 dpc and remains thereafter. Highly expressed in hematopoietic embryonic tissues from 10.5 dpc to 14.5 dpc. Strongly expressed in the yolk-sac. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. Inactive as a kinase due to its inability to bind ATP. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleolus cytoplasm protein phosphorylation peptidyl-serine phosphorylation protein phosphatase binding positive regulation of phosphoprotein phosphatase activity intracellular membrane-bounded organelle negative regulation of ERK1 and ERK2 cascade uc009gqr.1 uc009gqr.2 uc009gqr.3 uc009gqr.4 
ENSMUST00000002280.11 Smg9 ENSMUST00000002280.11 SMG9 nonsense mediated mRNA decay factor, transcript variant 4 (from RefSeq NR_184862.1) ENSMUST00000002280.1 ENSMUST00000002280.10 ENSMUST00000002280.2 ENSMUST00000002280.3 ENSMUST00000002280.4 ENSMUST00000002280.5 ENSMUST00000002280.6 ENSMUST00000002280.7 ENSMUST00000002280.8 ENSMUST00000002280.9 NR_184862 Q3TTB9 Q8BYJ3 Q9DB90 SMG9_MOUSE Smg9 uc009fpn.1 uc009fpn.2 uc009fpn.3 Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity). Plays a role in brain, heart, and eye development (PubMed:27018474). Self-associates to form homodimers and forms heterodimers with SMG8; these assembly forms may represent SMG1C intermediate forms (By similarity). Component of the SMG1C complex composed of SMG1, SMG8 and SMG9 (By similarity). Interacts with DHX34; the interaction is RNA- independent (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DB90-1; Sequence=Displayed; Name=2; IsoId=Q9DB90-2; Sequence=VSP_025947; Phosphorylated by SMG1. Embryonic lethal. Homozygous null embryos show a range of abnormalities, including edema, hemorrhage, exencephaly, preaxial polydactyly, decreased size of the mid- and hindbrains, microphthalmia, thin myocardium, and cardiac septal defects. These phenotypes are variable among mutant embryos; there is evidence of incomplete penetrance, but most embryos show clear phenotypic abnormalities. Belongs to the SMG9 family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay eye development in utero embryonic development brain development heart development identical protein binding uc009fpn.1 uc009fpn.2 uc009fpn.3 
ENSMUST00000002284.11 Plaur ENSMUST00000002284.11 plasminogen activator, urokinase receptor (from RefSeq NM_011113.4) ENSMUST00000002284.1 ENSMUST00000002284.10 ENSMUST00000002284.2 ENSMUST00000002284.3 ENSMUST00000002284.4 ENSMUST00000002284.5 ENSMUST00000002284.6 ENSMUST00000002284.7 ENSMUST00000002284.8 ENSMUST00000002284.9 NM_011113 Plaur Q545X5 Q545X5_MOUSE uc009fpr.1 uc009fpr.2 uc009fpr.3 uc009fpr.4 positive regulation of protein phosphorylation receptor binding plasma membrane cell surface membrane integral component of membrane kinase activity phosphorylation enzyme binding protein domain specific binding regulation of proteolysis urokinase plasminogen activator receptor activity urokinase plasminogen activator signaling pathway negative regulation of apoptotic process positive regulation of DNA binding positive regulation of epidermal growth factor receptor signaling pathway positive regulation of release of cytochrome c from mitochondria negative regulation of intrinsic apoptotic signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway uc009fpr.1 uc009fpr.2 uc009fpr.3 uc009fpr.4 
ENSMUST00000002289.8 Uchl3 ENSMUST00000002289.8 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) (from RefSeq NM_016723.2) ENSMUST00000002289.1 ENSMUST00000002289.2 ENSMUST00000002289.3 ENSMUST00000002289.4 ENSMUST00000002289.5 ENSMUST00000002289.6 ENSMUST00000002289.7 NM_016723 Q9EQX7 Q9JKB1 UCHL3_MOUSE uc007uvw.1 uc007uvw.2 uc007uvw.3 Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Inhibited by monoubiquitin and diubiquitin. Preferentially binds diubiquitin; the interaction does not hydrolyze diubiquitin but, in vitro, inhibits the hydrolyzing activity on other substrates. Cytoplasm Ubiquitously expressed, with highest levels in brain, liver, heart, thymus, kidney and testis. Highly expressed in the cauda epididymidis, in meiotic pachytene spermatocytes and post-meiotic spematids. In the retina, enriched in the photoreceptor inner segment. Expressed at 8.5 dpc in structures required for skeletal patterning. Highly expressed at 11 dpc, and decreases markedly from 15 dpc. Mice have no developmental defects, are fertile, and show normal T-cell differentiation. They have normal anxiety, locomotor behavior, motor function and synaptic transmission, but show defects in spatial learning and working memory. Exhibit stress-related effects with profound apoptosis-mediated germ cell loss and also, prominent retinal degeneration with photoreceptor cell apoptosis and mitochondrial oxidative stress. Mice show reduced capacity for adipocyte differentiation and impaired insulin responses. Belongs to the peptidase C12 family. thiol-dependent ubiquitin-specific protease activity nucleus cytoplasm cytosol proteolysis ubiquitin-dependent protein catabolic process adult walking behavior peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity protein catabolic process cellular response to insulin stimulus thiol-dependent ubiquitinyl hydrolase activity eating behavior ubiquitin binding positive regulation of fat cell differentiation retina development in camera-type eye ubiquitinyl hydrolase activity uc007uvw.1 uc007uvw.2 uc007uvw.3 
ENSMUST00000002291.12 Paxip1 ENSMUST00000002291.12 PAX interacting (with transcription-activation domain) protein 1 (from RefSeq NM_018878.4) ENSMUST00000002291.1 ENSMUST00000002291.10 ENSMUST00000002291.11 ENSMUST00000002291.2 ENSMUST00000002291.3 ENSMUST00000002291.4 ENSMUST00000002291.5 ENSMUST00000002291.6 ENSMUST00000002291.7 ENSMUST00000002291.8 ENSMUST00000002291.9 NM_018878 PAXI1_MOUSE Ptip Q6NZQ4 Q9Z0W6 uc033iie.1 uc033iie.2 uc033iie.3 This gene encodes a nuclear-localized protein that contains six BRCT1 (C-terminal of breast cancer susceptibility protein) domains. The encoded protein is involved in the repair of DNA double-strand breaks and is necessary for progression through cell division. The protein also functions in the regulation of transcription by recruiting histone methyltransferases to gene promoters bound by the sequence-specific transcription factor paired box protein 2 (Pax2). [provided by RefSeq, Mar 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF104261.1, BC066014.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes such as the MLL2/MLL3 complex. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires Rnf8 and Ube2n. Recruits Tp53bp1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with Tp53bp1 phosphorylated by Atm. Together with Tp53bp1 regulates Atm association (By similarity). Proposed to recruit Pagr1 to sites of DNA damage and the Pagr1:Paxip1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, this function has been questioned (PubMed:19124460, PubMed:26744420). Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and Rad51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL- containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as Pax2. Associates with gene promoters that are known to be regulated by Kmt2d/Mll2 (By similarity). During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys- 4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (PubMed:20671152, PubMed:26744420). Interacts with the C-terminal transactivation domain of PAX2 (PubMed:10908331). Forms a constitutive complex with PAGR1 independently of the MLL2/MLL3 complex (PubMed:19124460, PubMed:26744420). Interacts with TP53BP1 (when phosphorylated at the N- terminus by ATM) (By similarity). Interacts with HLTF (By similarity). Component of the KMT2 family MLL2/MLL3 complex (also named ASCOM complex), at least composed of the HMTs KMT2D and/or KMT2C, the common subunits ASH2L, RBBP5, WDR5 and DPY30, and the complex type-specific subunits PAXIP1/PTIP, PAGR1, NCOA6 and KDM6A; required for the association of PAGR1 with the MLL2/MLL3 complex (By similarity). Interacts with NUPR1; this interaction prevents PAXIP1 inhibition of PAX2 transcription factor activity (By similarity). Q6NZQ4; Q99L02: Pagr1a; NbExp=11; IntAct=EBI-1395317, EBI-11667455; Q6NZQ4; P32114: Pax2; NbExp=3; IntAct=EBI-1395317, EBI-1395232; Q6NZQ4; P32114-2: Pax2; NbExp=2; IntAct=EBI-1395317, EBI-1395250; Q6NZQ4; Q02650: Pax5; NbExp=3; IntAct=EBI-1395317, EBI-296260; Q6NZQ4; Q9BTK6: PAGR1; Xeno; NbExp=5; IntAct=EBI-1395317, EBI-2372223; Q6NZQ4; Q12888: TP53BP1; Xeno; NbExp=5; IntAct=EBI-1395317, EBI-396540; Nucleus matrix romosome Note=Localizes to DNA damage foci upon ionizing radiation. Expression detected in all tissues examined, including brain stem, cerebellum, cortex, heart, spleen, kidney, liver, thymus and lung. Highly expressed in embryonic kidney and brain. The BRCT 1 and 2 domains mediate the interaction with PAGR1A. The BRCT 5 and 6 domains mediate the association with the MLL2/MLL3 complex (PubMed:26744420). The BRCT 5 and 6 domains function as a single module and are necessary and sufficient for in vitro phospho-specific binding (substrates phosphorylated by the kinases ataxia telangiectasia-mutated (ATM), ataxia telangiectasia and RAD3- related (ATR) in response to gamma irradiation). In contrast, in vivo two pairs of BRCT domains (3-6) bind to phosphorylated TP53BP1 much more efficiently. Mice are developmentally retarded, disorganized, and embryonic lethal by 9.5 dpc. Mutant cells appear to replicate DNA but show reduced levels of mitosis and widespread cell death by 8.5 dpc. DNA damage appears to precede nuclear condensation at 7 dpc. Reduced levels of histone H3 methylated at 'Lys-4 in developing tissues. The terminology of MLL proteins in mammalia is not consistent also concerning the terminology of MLL protein-containing complexes. The decribed MLL2/MLL3 complex is commonly described as MLL3/MLL4 complex in literature. positive regulation of histone H3-K36 methylation vasculogenesis protein binding nucleus nucleoplasm chromosome DNA repair DNA recombination cellular response to DNA damage stimulus response to ionizing radiation nuclear matrix DNA damage response, signal transduction by p53 class mediator positive regulation of protein ubiquitination positive regulation of histone acetylation histone methyltransferase complex negative regulation of sequence-specific DNA binding transcription factor activity endothelial cell migration MLL3/4 complex positive regulation of isotype switching positive regulation of isotype switching to IgG isotypes histone H3-K4 methylation positive regulation of histone H3-K4 methylation positive regulation of transcription initiation from RNA polymerase II promoter adipose tissue development chorion development regulation of cell cycle G2/M phase transition positive regulation of response to DNA damage stimulus uc033iie.1 uc033iie.2 uc033iie.3 
ENSMUST00000002292.15 Rmnd5a ENSMUST00000002292.15 required for meiotic nuclear division 5 homolog A, transcript variant 1 (from RefSeq NM_024288.3) E9QNK7 ENSMUST00000002292.1 ENSMUST00000002292.10 ENSMUST00000002292.11 ENSMUST00000002292.12 ENSMUST00000002292.13 ENSMUST00000002292.14 ENSMUST00000002292.2 ENSMUST00000002292.3 ENSMUST00000002292.4 ENSMUST00000002292.5 ENSMUST00000002292.6 ENSMUST00000002292.7 ENSMUST00000002292.8 ENSMUST00000002292.9 NM_024288 Q3TPH1 Q3UFE2 Q80YQ8 RMD5A_MOUSE uc009cgu.1 uc009cgu.2 uc009cgu.3 Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Nucleus, nucleoplasm Cytoplasm Sequence=BAE28619.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ubiquitin ligase complex protein polyubiquitination ubiquitin-protein transferase activity nucleus nucleoplasm cytoplasm ubiquitin-dependent protein catabolic process transferase activity GID complex proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding uc009cgu.1 uc009cgu.2 uc009cgu.3 
ENSMUST00000002298.7 Ppm1j ENSMUST00000002298.7 protein phosphatase 1J (from RefSeq NM_027982.2) ENSMUST00000002298.1 ENSMUST00000002298.2 ENSMUST00000002298.3 ENSMUST00000002298.4 ENSMUST00000002298.5 ENSMUST00000002298.6 NM_027982 PPM1J_MOUSE Ppp2cz Q149T7 Q810X6 Q9D7H6 uc008quk.1 uc008quk.2 uc008quk.3 Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Interacts with UBE2I/UBC9. Specifically expressed in the testicular germ cells. Belongs to the PP2C family. Sequence=BAB26156.1; Type=Erroneous initiation; Evidence=; catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity [pyruvate dehydrogenase (lipoamide)] phosphatase activity protein binding mitochondrion protein dephosphorylation hydrolase activity positive regulation of pyruvate dehydrogenase activity uc008quk.1 uc008quk.2 uc008quk.3 
ENSMUST00000002305.9 Kdm7a ENSMUST00000002305.9 lysine (K)-specific demethylase 7A (from RefSeq NM_001033430.4) A6H6E5 ENSMUST00000002305.1 ENSMUST00000002305.2 ENSMUST00000002305.3 ENSMUST00000002305.4 ENSMUST00000002305.5 ENSMUST00000002305.6 ENSMUST00000002305.7 ENSMUST00000002305.8 Jhdm1d KDM7A_MOUSE Kdm7 Kiaa1718 NM_001033430 Q3UWM4 Q3UWN8 Q6ZPJ5 Q8C969 Q8C9E0 Q91VX8 uc009blj.1 uc009blj.2 uc009blj.3 uc009blj.4 Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys- 4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. Reaction=2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60188, Rhea:RHEA-COMP:15541, Rhea:RHEA- COMP:15546, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61976; EC=1.14.11.65; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60189; Evidence=; Reaction=2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:67800, Rhea:RHEA-COMP:15539, Rhea:RHEA- COMP:15548, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67801; Evidence=; Reaction=2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate; Xref=Rhea:RHEA:21788, Rhea:RHEA-COMP:9786, Rhea:RHEA- COMP:9787, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21789; Evidence=; Reaction=2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2 = CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate; Xref=Rhea:RHEA:67804, Rhea:RHEA-COMP:15554, Rhea:RHEA-COMP:15555, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67805; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Nucleus The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2. The linker region is a critical determinant of demethylase specificity. It prevents the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3, while it favors selectivity toward H3K27me2. Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. Sequence=AAI45849.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE22876.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; iron ion binding nucleus nucleoplasm nucleolus chromatin organization nervous system development zinc ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors midbrain development histone demethylase activity (H3-K9 specific) histone H3-K9 demethylation methylated histone binding histone H4-K20 demethylation histone demethylase activity (H4-K20 specific) positive regulation of transcription, DNA-templated metal ion binding dioxygenase activity histone demethylase activity (H3-K36 specific) oxidation-reduction process histone H3-K36 demethylation histone H3-K27 demethylation histone demethylase activity (H3-K27 specific) uc009blj.1 uc009blj.2 uc009blj.3 uc009blj.4 
ENSMUST00000002320.16 Ppard ENSMUST00000002320.16 peroxisome proliferator activator receptor delta, transcript variant 1 (from RefSeq NM_011145.4) ENSMUST00000002320.1 ENSMUST00000002320.10 ENSMUST00000002320.11 ENSMUST00000002320.12 ENSMUST00000002320.13 ENSMUST00000002320.14 ENSMUST00000002320.15 ENSMUST00000002320.2 ENSMUST00000002320.3 ENSMUST00000002320.4 ENSMUST00000002320.5 ENSMUST00000002320.6 ENSMUST00000002320.7 ENSMUST00000002320.8 ENSMUST00000002320.9 NM_011145 PPARb/d Ppard Q546I3 Q546I3_MOUSE uc008bqk.1 uc008bqk.2 uc008bqk.3 Nucleus Belongs to the nuclear hormone receptor family. NR1 subfamily. DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding fatty acid binding nucleus proteoglycan metabolic process regulation of transcription, DNA-templated lipid metabolic process vitamin A metabolic process apoptotic process heart development embryo implantation transcription factor binding drug binding zinc ion binding lipid binding phospholipid biosynthetic process mRNA transcription response to glucose response to organic substance response to activity negative regulation of smooth muscle cell migration fatty acid oxidation negative regulation of cell growth intracellular receptor signaling pathway positive regulation of insulin secretion negative regulation of collagen biosynthetic process response to vitamin A negative regulation of apoptotic process steroid hormone mediated signaling pathway sequence-specific DNA binding positive regulation of epidermis development positive regulation of transcription, DNA-templated decidualization metal ion binding negative regulation of smooth muscle cell proliferation negative regulation of inflammatory response NF-kappaB binding linoleic acid binding cellular response to lipopolysaccharide apoptotic signaling pathway uc008bqk.1 uc008bqk.2 uc008bqk.3 
ENSMUST00000002327.6 Def6 ENSMUST00000002327.6 differentially expressed in FDCP 6 (from RefSeq NM_027185.3) A0A0R4IZX1 A0A0R4IZX1_MOUSE Def6 ENSMUST00000002327.1 ENSMUST00000002327.2 ENSMUST00000002327.3 ENSMUST00000002327.4 ENSMUST00000002327.5 NM_027185 uc008bqi.1 uc008bqi.2 uc008bqi.3 nucleoplasm cytosol uc008bqi.1 uc008bqi.2 uc008bqi.3 
ENSMUST00000002336.16 Zim1 ENSMUST00000002336.16 zinc finger, imprinted 1 (from RefSeq NM_011769.4) ENSMUST00000002336.1 ENSMUST00000002336.10 ENSMUST00000002336.11 ENSMUST00000002336.12 ENSMUST00000002336.13 ENSMUST00000002336.14 ENSMUST00000002336.15 ENSMUST00000002336.2 ENSMUST00000002336.3 ENSMUST00000002336.4 ENSMUST00000002336.5 ENSMUST00000002336.6 ENSMUST00000002336.7 ENSMUST00000002336.8 ENSMUST00000002336.9 NM_011769 Q8C393 Q8C393_MOUSE Zim1 uc009fbv.1 uc009fbv.2 uc009fbv.3 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009fbv.1 uc009fbv.2 uc009fbv.3 
ENSMUST00000002350.11 Ciao3 ENSMUST00000002350.11 cytosolic iron-sulfur assembly component 3 (from RefSeq NM_026238.4) CIAO3_MOUSE ENSMUST00000002350.1 ENSMUST00000002350.10 ENSMUST00000002350.2 ENSMUST00000002350.3 ENSMUST00000002350.4 ENSMUST00000002350.5 ENSMUST00000002350.6 ENSMUST00000002350.7 ENSMUST00000002350.8 ENSMUST00000002350.9 NM_026238 Narfl Q3ULM7 Q7TMW6 Q8BRR3 Q9CXS6 Q9D320 uc008bbq.1 uc008bbq.2 uc008bbq.3 Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity). External component of the CIA complex. In the CIA complex, interacts directly with CIAO1 and MMS19. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TMW6-1; Sequence=Displayed; Name=2; IsoId=Q7TMW6-2; Sequence=VSP_025696; Belongs to the NARF family. response to hypoxia hematopoietic progenitor cell differentiation regulation of gene expression iron-sulfur cluster assembly oxygen homeostasis metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding CIA complex uc008bbq.1 uc008bbq.2 uc008bbq.3 
ENSMUST00000002360.17 Angptl4 ENSMUST00000002360.17 angiopoietin-like 4 (from RefSeq NM_020581.2) ANGL4_MOUSE ENSMUST00000002360.1 ENSMUST00000002360.10 ENSMUST00000002360.11 ENSMUST00000002360.12 ENSMUST00000002360.13 ENSMUST00000002360.14 ENSMUST00000002360.15 ENSMUST00000002360.16 ENSMUST00000002360.2 ENSMUST00000002360.3 ENSMUST00000002360.4 ENSMUST00000002360.5 ENSMUST00000002360.6 ENSMUST00000002360.7 ENSMUST00000002360.8 ENSMUST00000002360.9 Farp Fiaf NM_020581 Ng27 Q78ZJ9 Q9JHX7 Q9JLX7 Q9Z1P8 uc008bzp.1 uc008bzp.2 uc008bzp.3 uc008bzp.4 Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:15837923, PubMed:17609370, PubMed:29899519). May also play a role in regulating glucose homeostasis and insulin sensitivity (PubMed:15837923, PubMed:29899519). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (PubMed:14583458, PubMed:17130448, PubMed:21832056). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (Probable). [ANGPTL4 N-terminal chain]: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein. Homooligomer; disulfide-linked via Cys residues in the N- terminal part of the protein (PubMed:14583458). The homooligomer undergoes proteolytic processing to release the ANGPTL4 C-terminal chain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix (By similarity). Secreted creted, extracellular space, extracellular matrix Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4. Detected in liver and kidney (PubMed:10698685, PubMed:17609370). Predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver. Detected in endothelial cells in the capillary plexus, veins and arteries in the retina at 2, 12 and 17 days after birth (PubMed:21832056). Expressed at low levels in most organs and connective tissue at 13.5 dpc. Between 15.5 dpc and 18.5 dpc, strongest expression in brown fat. Induced in interstitial capillaries in response to hind leg ischemia (PubMed:17068295). Alterations in nutrition and leptin administration are found to modulate the expression in vivo. N-glycosylated. [ANGPTL4 N-terminal chain]: Forms disulfide-linked dimers and tetramers. Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain; both cleaved and uncleaved forms are detected in the extracellular space. The cleaved form is not present within the cell. Pups are born at less than the expected Mendelian rate, indicative of significant embryonic lethality. No obvious phenotype after birth; mice are viable and fertile (PubMed:21832056). Mutant mice have reduced circulating triglyceride and cholesterol levels when fed a high-fat diet (PubMed:17609370, PubMed:29899519). Besides, they display 30% lower non-fasted blood glucose levels and improved glucose tolerance when fed a high-fat diet. In contrast, glucose levels and glucose tolerance are not different from wild-type when mice are kept on a normal diet (PubMed:29899519). The retinal vascular network displays subtle alterations, including a somewhat larger diameter of veins and capillaries. Pups display a delay in pericyte spreading on newly formed capillaries in the retina, and defects in the organization of endothelial cell tight junctions. In retinas from 17 day old animals, hypoxia-induced pathological neovascularization is strongly reduced (PubMed:21832056). Some studies observed decreased survival of suckling pups and of adults kept on a high-fat diet due to intestinal pathologies, with lipogranulomatous lesions of the intestines and their draining lymphatics and mesenteric lymph nodes (PubMed:17609370). Other studies observed no such effects (PubMed:29899519). Upon heterologous expression under the control of the keratinocyte promoter in the skin, inhibits tumor-associated angiogenesis and tumor growth (PubMed:14583458). In xenograft models, it inhibits both intra- and extravasation of tumor cells as well as vascular permeability leading to inhibition of metastases. Expression by tumor cells induces reorganization of the actin cytoskeleton through inhibition of actin stress fiber formation and vinculin localization at focal contacts. It might prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness (PubMed:17130448). angiogenesis response to hypoxia enzyme inhibitor activity extracellular region extracellular space lipid metabolic process cellular response to starvation identical protein binding negative regulation of apoptotic process protein unfolding positive regulation of lipid metabolic process negative regulation of lipoprotein lipase activity protein homooligomerization triglyceride homeostasis negative regulation of endothelial cell apoptotic process uc008bzp.1 uc008bzp.2 uc008bzp.3 uc008bzp.4 
ENSMUST00000002379.15 Cd320 ENSMUST00000002379.15 CD320 antigen, transcript variant 1 (from RefSeq NM_019421.3) CD320_MOUSE ENSMUST00000002379.1 ENSMUST00000002379.10 ENSMUST00000002379.11 ENSMUST00000002379.12 ENSMUST00000002379.13 ENSMUST00000002379.14 ENSMUST00000002379.2 ENSMUST00000002379.3 ENSMUST00000002379.4 ENSMUST00000002379.5 ENSMUST00000002379.6 ENSMUST00000002379.7 ENSMUST00000002379.8 ENSMUST00000002379.9 NM_019421 Q3V2Q4 Q7TSW0 Q8C2Q4 Q9CWC2 Q9Z1P5 uc008bzv.1 uc008bzv.2 Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as a costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Interacts (via LDL-receptor class A domains) with TCN2. Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z1P5-1; Sequence=Displayed; Name=2; IsoId=Q9Z1P5-2; Sequence=VSP_035723; Sequence=CAD91188.1; Type=Miscellaneous discrepancy; Evidence=; calcium ion binding endoplasmic reticulum plasma membrane integral component of plasma membrane signal transduction growth factor activity cobalamin transport membrane integral component of membrane regulation of vitamin metabolic process positive regulation of B cell proliferation B cell costimulation cobalamin binding metal ion binding uc008bzv.1 uc008bzv.2 
ENSMUST00000002395.8 Rec8 ENSMUST00000002395.8 REC8 meiotic recombination protein, transcript variant 1 (from RefSeq NM_020002.3) ENSMUST00000002395.1 ENSMUST00000002395.2 ENSMUST00000002395.3 ENSMUST00000002395.4 ENSMUST00000002395.5 ENSMUST00000002395.6 ENSMUST00000002395.7 Mei8 NM_020002 Q3UIN9 Q8C5S7 Q9JK52 REC8_MOUSE Rec8L1 uc007tzo.1 uc007tzo.2 uc007tzo.3 uc007tzo.4 Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II. Interacts (phosphorylated and unphosphorylated form) with SMC3. Interacts with SYCP3. Interacts (phosphorylated and unphosphorylated form) with SMC1B. Does not interact with SMC1A. Interacts with RAD51. Forms a complex with EWSR1, PRDM9, SYCP3 and SYCP1; complex formation is dependent of phosphorylated form of REC8 and requires PRDM9 bound to hotspot DNA; EWSR1 joins PRDM9 with the chromosomal axis through REC8 (PubMed:27932493). Nucleus romosome romosome, centromere te=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II. Expressed primarily in the gonads. In the testis, expressed in pachytene spermatocytes and in spermatids. Not expressed in spermatogonia or somatic cells. In the ovary, expressed only in oocytes. Low levels also detected in a number of somatic tissues including thymus, lung, liver, kidney and small intestine. Expressed from 2 weeks postpartum (at protein level). Phosphorylated. Mice display a high mortality rate, both during embryogenesis and after birth, germ cell failure and sterility. Mutant females exhibit ovarian dysgenesis and lack ovarian follicles at reproductive maturity. Affected males have small testes due to arrest of spermatogenesis during meiotic prophase I. Early chromosome pairing appears normal but synapsis occurs between sister chromatids rather than between homologous chromosomes. Belongs to the rad21 family. double-strand break repair via homologous recombination chromosome, centromeric region condensed nuclear chromosome kinetochore condensed nuclear chromosome, centromeric region condensed chromosome condensed nuclear chromosome synaptonemal complex lateral element oocyte maturation male germ cell nucleus chromatin binding protein binding nucleus nucleoplasm chromosome double-strand break repair chromosome segregation sister chromatid cohesion synapsis synaptonemal complex assembly male meiosis I spermatid development cohesin complex fertilization meiotic cohesin complex nuclear meiotic cohesin complex meiotic cell cycle seminiferous tubule development uc007tzo.1 uc007tzo.2 uc007tzo.3 uc007tzo.4 
ENSMUST00000002397.7 Gmpr2 ENSMUST00000002397.7 guanosine monophosphate reductase 2 (from RefSeq NM_177992.2) ENSMUST00000002397.1 ENSMUST00000002397.2 ENSMUST00000002397.3 ENSMUST00000002397.4 ENSMUST00000002397.5 ENSMUST00000002397.6 GMPR2_MOUSE Gmpr2 NM_177992 Q542X2 Q8R1T5 Q99L27 uc007uae.1 uc007uae.2 uc007uae.3 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity). Reaction=IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH; Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115, ChEBI:CHEBI:58349; EC=1.7.1.7; Evidence= Homotetramer. Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. catalytic activity GMP reductase activity purine nucleobase metabolic process purine nucleotide metabolic process nucleotide metabolic process purine ribonucleotide interconversion oxidoreductase activity monocyte differentiation GMP metabolic process GMP catabolic process metal ion binding oxidation-reduction process GMP reductase complex uc007uae.1 uc007uae.2 uc007uae.3 
ENSMUST00000002400.7 Mdp1 ENSMUST00000002400.7 magnesium-dependent phosphatase 1, transcript variant 1 (from RefSeq NM_023397.5) ENSMUST00000002400.1 ENSMUST00000002400.2 ENSMUST00000002400.3 ENSMUST00000002400.4 ENSMUST00000002400.5 ENSMUST00000002400.6 MGDP1_MOUSE NM_023397 Q9D967 uc007uaa.1 uc007uaa.2 uc007uaa.3 Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by vanadate and zinc, and slightly by calcium. Kinetic parameters: KM=9.5 mM for ribose-5-phosphate ; KM=5.6 mM for 2-deoxy-ribose-5-phosphate ; KM=15 mM for phosphotyrosine ; KM=1.1 mM for arabinose-5-phosphate ; KM=21 mM for fructose-6-phosphate ; KM=12 mM for 5'-CMP ; KM=1.7 mM for pNPP ; KM=26 mM for 5'-AMP ; KM=31 mM for glucose-6-phosphate ; Note=Dephosphorylates ribose-5-phosphate, 2-deoxy-ribose-5-phosphate, phosphotyrosine, arabinose-5-phosphate, fructose-6-phosphate, 5'-CMP, pNPP, 5'-AMP and glucose-6-phosphate with a decreasing relative rate of 1, 0.9, 0.8, 0.6, 0.5, 0.2, 0.2, 0.2 and 0.06. Dephosphorylates phosphotyrosine with a greater than 100 fold rate over phosphoserine or phosphothreonine.; pH dependence: Optimum pH is 5.3. ; Belongs to the HAD-like hydrolase superfamily. acid phosphatase activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein dephosphorylation dephosphorylation hydrolase activity phosphatase activity fructosamine metabolic process peptidyl-tyrosine dephosphorylation metal ion binding uc007uaa.1 uc007uaa.2 uc007uaa.3 
ENSMUST00000002403.10 Dhrs1 ENSMUST00000002403.10 dehydrogenase/reductase 1 (from RefSeq NM_026819.3) D14ertd484e DHRS1_MOUSE Dhrs1 ENSMUST00000002403.1 ENSMUST00000002403.2 ENSMUST00000002403.3 ENSMUST00000002403.4 ENSMUST00000002403.5 ENSMUST00000002403.6 ENSMUST00000002403.7 ENSMUST00000002403.8 ENSMUST00000002403.9 NM_026819 Q3THW0 Q99L04 Q9D148 uc007uan.1 uc007uan.2 uc007uan.3 uc007uan.4 NADPH-dependent oxidoreductase which catalyzes the reduction of some steroids (estrone, androstene-3,17-dione and cortisone) as well as prostaglandin E1, isatin and xenobiotics in vitro. May have a role in steroid and/or xenobiotic metabolism. Reaction=17alpha-estradiol + NADP(+) = estrone + H(+) + NADPH; Xref=Rhea:RHEA:16705, ChEBI:CHEBI:15378, ChEBI:CHEBI:17160, ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:16707; Evidence=; Reaction=NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH; Xref=Rhea:RHEA:14981, ChEBI:CHEBI:15378, ChEBI:CHEBI:16422, ChEBI:CHEBI:17347, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:14983; Evidence=; Reaction=H(+) + NADPH + prostaglandin E1 = NADP(+) + prostaglandin F1; Xref=Rhea:RHEA:68612, ChEBI:CHEBI:15378, ChEBI:CHEBI:57397, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:178049; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68613; Evidence=; Reaction=H(+) + isatin + NADPH = 3-hydroxyindolin-2-one + NADP(+); Xref=Rhea:RHEA:68608, ChEBI:CHEBI:15378, ChEBI:CHEBI:27539, ChEBI:CHEBI:28536, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68609; Evidence=; Endoplasmic reticulum Note=May be attached to the ER membrane by its C-terminus segment. May be attached to the ER membrane by its C-terminus segment. Belongs to the short-chain dehydrogenases/reductases (SDR) family. molecular_function mitochondrion mitochondrial inner membrane endoplasmic reticulum biological_process oxidoreductase activity oxidation-reduction process uc007uan.1 uc007uan.2 uc007uan.3 uc007uan.4 
ENSMUST00000002412.9 Ncan ENSMUST00000002412.9 neurocan (from RefSeq NM_007789.3) A0A0R4IZX5 A0A0R4IZX5_MOUSE ENSMUST00000002412.1 ENSMUST00000002412.2 ENSMUST00000002412.3 ENSMUST00000002412.4 ENSMUST00000002412.5 ENSMUST00000002412.6 ENSMUST00000002412.7 ENSMUST00000002412.8 NM_007789 Ncan uc009lys.1 uc009lys.2 uc009lys.3 uc009lys.4 Belongs to the aggrecan/versican proteoglycan family. Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding hyaluronic acid binding cell adhesion uc009lys.1 uc009lys.2 uc009lys.3 uc009lys.4 
ENSMUST00000002413.15 Tmem161a ENSMUST00000002413.15 transmembrane protein 161A, transcript variant 1 (from RefSeq NM_145597.5) ENSMUST00000002413.1 ENSMUST00000002413.10 ENSMUST00000002413.11 ENSMUST00000002413.12 ENSMUST00000002413.13 ENSMUST00000002413.14 ENSMUST00000002413.2 ENSMUST00000002413.3 ENSMUST00000002413.4 ENSMUST00000002413.5 ENSMUST00000002413.6 ENSMUST00000002413.7 ENSMUST00000002413.8 ENSMUST00000002413.9 NM_145597 Q8BNL7 Q8BSL1 Q8C2I8 Q8VCA6 T161A_MOUSE uc009lzc.1 uc009lzc.2 uc009lzc.3 uc009lzc.4 May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis (By similarity). Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VCA6-1; Sequence=Displayed; Name=2; IsoId=Q8VCA6-2; Sequence=VSP_025644; Name=3; IsoId=Q8VCA6-3; Sequence=VSP_025643, VSP_025645; Belongs to the TMEM161 family. Sequence=BAC40428.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component membrane integral component of membrane response to retinoic acid cellular response to oxidative stress cellular response to UV positive regulation of DNA repair negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage uc009lzc.1 uc009lzc.2 uc009lzc.3 uc009lzc.4 
ENSMUST00000002418.15 Borcs8 ENSMUST00000002418.15 BLOC-1 related complex subunit 8, transcript variant 2 (from RefSeq NM_001309645.1) BORC8_MOUSE Borcs8 ENSMUST00000002418.1 ENSMUST00000002418.10 ENSMUST00000002418.11 ENSMUST00000002418.12 ENSMUST00000002418.13 ENSMUST00000002418.14 ENSMUST00000002418.2 ENSMUST00000002418.3 ENSMUST00000002418.4 ENSMUST00000002418.5 ENSMUST00000002418.6 ENSMUST00000002418.7 ENSMUST00000002418.8 ENSMUST00000002418.9 NM_001309645 Q9D6Y4 uc009lyy.1 uc009lyy.2 uc009lyy.3 uc009lyy.4 uc009lyy.5 As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. Lysosome membrane Belongs to the BORCS8 family. molecular_function lysosome lysosomal membrane biological_process membrane BORC complex uc009lyy.1 uc009lyy.2 uc009lyy.3 uc009lyy.4 uc009lyy.5 
ENSMUST00000002436.11 Snx9 ENSMUST00000002436.11 sorting nexin 9 (from RefSeq NM_025664.6) ENSMUST00000002436.1 ENSMUST00000002436.10 ENSMUST00000002436.2 ENSMUST00000002436.3 ENSMUST00000002436.4 ENSMUST00000002436.5 ENSMUST00000002436.6 ENSMUST00000002436.7 ENSMUST00000002436.8 ENSMUST00000002436.9 NM_025664 Q91VH2 SNX9_MOUSE uc008afj.1 uc008afj.2 uc008afj.3 Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin- independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton (PubMed:23437151). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate (By similarity). Homodimer, and homooligomer. Heterodimer with SNX18. Interacts with ITCH. Interacts (via SH3 domain) with TNK2, WASL and ACTR3. Identified in a complex with TNK2 and clathrin heavy chains. Identified in a complex with the AP-2 complex, clathrin and DNM2. Interacts (via SH3 domain) with DNM1 and DNM2. Identified in an oligomeric complex containing DNM1 and SNX9 (By similarity). Interacts with FCHSD1 (PubMed:23437151). Interacts with ADAM9 and ADAM15 cytoplasmic tails (PubMed:10531379). Q91VH2; Q01968: OCRL; Xeno; NbExp=2; IntAct=EBI-8429356, EBI-6148898; Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, clathrin-coated vesicle Golgi apparatus, trans-Golgi network Cell projection, ruffle Cytoplasm Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation (By similarity). Colocalizes with the actin cytoskeleton at the cell membrane (By similarity). Detected in inner ear vestibula and in the cuticular plate of cochlear hair cells (at protein level). The PX domain mediates interaction with membranes enriched in phosphatidylinositol phosphate. Has high affinity for phosphatidylinositol 4,5-bisphosphate, but can also bind to membranes enriched in other phosphatidylinositol phosphates. Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR (By similarity). Ubiquitinated by ITCH. Belongs to the sorting nexin family. mitotic cell cycle mitotic cytokinesis ruffle protein binding 1-phosphatidylinositol binding cytoplasm Golgi apparatus trans-Golgi network cytosol plasma membrane intracellular protein transport endocytosis receptor-mediated endocytosis cell cycle lipid binding protein transport membrane endosomal transport clathrin-coated vesicle cytoplasmic vesicle membrane positive regulation of actin filament polymerization extrinsic component of cytoplasmic side of plasma membrane cytoplasmic vesicle ubiquitin protein ligase binding positive regulation of protein oligomerization phosphatidylinositol binding cleavage furrow formation identical protein binding protein homodimerization activity cell projection positive regulation of GTPase activity positive regulation of protein kinase activity positive regulation of membrane protein ectodomain proteolysis cell division lipid tube assembly Arp2/3 complex binding plasma membrane tubulation cuticular plate uc008afj.1 uc008afj.2 uc008afj.3 
ENSMUST00000002444.15 Rfx2 ENSMUST00000002444.15 regulatory factor X, 2 (influences HLA class II expression), transcript variant 1 (from RefSeq NM_027787.2) ENSMUST00000002444.1 ENSMUST00000002444.10 ENSMUST00000002444.11 ENSMUST00000002444.12 ENSMUST00000002444.13 ENSMUST00000002444.14 ENSMUST00000002444.2 ENSMUST00000002444.3 ENSMUST00000002444.4 ENSMUST00000002444.5 ENSMUST00000002444.6 ENSMUST00000002444.7 ENSMUST00000002444.8 ENSMUST00000002444.9 NM_027787 P48379 Q8BXR3 RFX2_MOUSE uc008ddg.1 uc008ddg.2 uc008ddg.3 uc008ddg.4 Transcription factor that acts as a key regulator of spermatogenesis (PubMed:26248850, PubMed:26162102, PubMed:26853561). Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (PubMed:26162102, PubMed:26853561). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:15229132, PubMed:26162102). Probably activates transcription of the testis-specific histone gene H1-6 (PubMed:15229132). Homodimer; probably only forms homodimers in testis (PubMed:15229132). Heterodimer; heterodimerizes with RFX1 and RFX3 (PubMed:15229132). Nucleus toplasm Note=Mainly expressed in the nucleus and at lower level in cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48379-1; Sequence=Displayed; Name=2; IsoId=P48379-2; Sequence=VSP_037812; Detected in the anterior primitive streak preceding the morphological appearance of the node at 7.0 dpc. Expressed in the node and in the midline notochordal plate cells extending anteriorly from the node at 7.5 dpc. At 8.5 dpc, expressed in the node now located in the tail region. At 9.5 dpc, detected in the floor plate and in the dorsal portion of the neural tube, with highest expression in the anterior portion of the spinal cord. Also expressed in the developing gut. At 10.5 dpc, also observed in the telencephalon region of the brain and in the anterior portion of the limb bud at 12.5 dpc (PubMed:26248850). Localizes to cells at the posterior margin of the ciliated organ of asymmetry (PubMed:22233545). Mice are perfectly viable but show complete male sterility (PubMed:26248850, PubMed:26162102, PubMed:26853561). Spermatogenesis proceeds normally through meiosis. However, haploid cells undergo a complete arrest in spermatid development before spermatid elongation (PubMed:26248850, PubMed:26162102). Arrested cells show altered Golgi apparatus organization, leading to a deficit in the generation of a spreading acrosomal cap from proacrosomal vesicles and merge to form giant multinucleated cells released to the epididymis. Spermatids also completely fail to form the flagellar axoneme (PubMed:26162102). Belongs to the RFX family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding acrosome assembly DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter spermatogenesis spermatid development cell projection organization cell differentiation positive regulation of transcription from RNA polymerase II promoter cilium assembly cellular response to leukemia inhibitory factor uc008ddg.1 uc008ddg.2 uc008ddg.3 uc008ddg.4 
ENSMUST00000002445.10 Ranbp3 ENSMUST00000002445.10 RAN binding protein 3, transcript variant 4 (from RefSeq NR_045519.1) A6H6I9 ENSMUST00000002445.1 ENSMUST00000002445.2 ENSMUST00000002445.3 ENSMUST00000002445.4 ENSMUST00000002445.5 ENSMUST00000002445.6 ENSMUST00000002445.7 ENSMUST00000002445.8 ENSMUST00000002445.9 NR_045519 Q3TIS4 Q3U2G4 Q3UYG7 Q9CT10 RANB3_MOUSE uc008dcv.1 uc008dcv.2 uc008dcv.3 uc008dcv.4 Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export (By similarity). Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1. Interacts (via its C-terminal R domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear export of SMAD2 and termination of the TGF-beta signaling. Interacts (via its C-terminal R domain) with SMAD3 (dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and termination of the TGF-beta signaling (By similarity). Cytoplasm Nucleus nucleus nuclear pore nucleoplasm cytoplasm protein export from nucleus Ran GTPase binding protein transport positive regulation of GTPase activity intracellular transport R-SMAD binding GTPase activator activity uc008dcv.1 uc008dcv.2 uc008dcv.3 uc008dcv.4 
ENSMUST00000002452.8 Ndufa11 ENSMUST00000002452.8 NADH:ubiquinone oxidoreductase subunit A11 (from RefSeq NM_027244.1) ENSMUST00000002452.1 ENSMUST00000002452.2 ENSMUST00000002452.3 ENSMUST00000002452.4 ENSMUST00000002452.5 ENSMUST00000002452.6 ENSMUST00000002452.7 G5E814 G5E814_MOUSE NM_027244 Ndufa11 uc008dcz.1 uc008dcz.2 uc008dcz.3 uc008dcz.4 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Multi-pass membrane protein ; Matrix side Belongs to the complex I NDUFA11 subunit family. mitochondrial respiratory chain complex I assembly uc008dcz.1 uc008dcz.2 uc008dcz.3 uc008dcz.4 
ENSMUST00000002456.10 Nt5c1b ENSMUST00000002456.10 5'-nucleotidase, cytosolic IB, transcript variant 13 (from RefSeq NR_164205.1) 5NT1B_MOUSE Airp E9QNH2 ENSMUST00000002456.1 ENSMUST00000002456.2 ENSMUST00000002456.3 ENSMUST00000002456.4 ENSMUST00000002456.5 ENSMUST00000002456.6 ENSMUST00000002456.7 ENSMUST00000002456.8 ENSMUST00000002456.9 NR_164205 Q91Y48 Q91YE9 uc007nap.1 uc007nap.2 uc007nap.3 uc007nap.4 Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, AMP is the major substrate. Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377, ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5; Evidence=; Reaction=AMP + H2O = adenosine + phosphate; Xref=Rhea:RHEA:29375, ChEBI:CHEBI:15377, ChEBI:CHEBI:16335, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by ADP. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91YE9-1; Sequence=Displayed; Name=2; IsoId=Q91YE9-2; Sequence=VSP_010204, VSP_010205; Expressed at highest levels in testis. Also expressed in brain, skeletal muscle, kidney and heart. Belongs to the 5'-nucleotidase type 3 family. Sequence=AAK39109.1; Type=Erroneous initiation; Evidence=; nucleotide binding magnesium ion binding cytoplasm cytosol 5'-nucleotidase activity nucleoside metabolic process nucleotide metabolic process dephosphorylation hydrolase activity adenosine metabolic process uc007nap.1 uc007nap.2 uc007nap.3 uc007nap.4 
ENSMUST00000002457.2 Bmp8b ENSMUST00000002457.2 bone morphogenetic protein 8b (from RefSeq NM_007559.5) BMP8B_MOUSE ENSMUST00000002457.1 NM_007559 P55105 Q8BNM2 uc008uot.1 uc008uot.2 uc008uot.3 uc008uot.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein may play a role in the generation of primordial germ cells, and has been shown to stimulate thermogenesis in brown adipose tissue. Male mice lacking a functional copy of this gene exhibit variable degrees of germ-cell deficiency. Homozygous knockout mice of both sexes exhibit impaired thermogenesis and reduced metabolic rate, resulting in weight gain. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 4. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U39545.1, AK082895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Involved in the generation of primordial germ cells; this function involves Bmp4 in a synergistic manner though separate receptor complexes seem to be involved. Required for the initiation and maintenance of spermatogenesis. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT. Homodimer; disulfide-linked. Secreted Expressed in testis. Expressed in decidual cells of the uterus and in trophoblast cells of the labyrinthine region of the placenta and in the inner root sheath of hair follicles of early postnatal skin. Expressed in the extraembryonic ectoderm in pregastrula and gastrula stage mouse embryos. Expressed in brown adipose tissue and brain. Expressed during specific stages of spermatogenesis, with highest levels in stage 6-8 round spermatids after 3 weeks of age. By feeding with high-fat diet and cold exposure. By beta-3- adrenergic receptor activation and thyroid hormone treatment. Absence of primordial germ cells, short or missing allantois. Belongs to the TGF-beta family. ossification diet induced thermogenesis cytokine activity transforming growth factor beta receptor binding extracellular region extracellular space transforming growth factor beta receptor signaling pathway multicellular organism development germ cell development spermatogenesis growth factor activity positive regulation of pathway-restricted SMAD protein phosphorylation cell differentiation regulation of apoptotic process regulation of MAPK cascade cell development embryonic morphogenesis cartilage development SMAD protein signal transduction energy homeostasis uc008uot.1 uc008uot.2 uc008uot.3 uc008uot.4 
ENSMUST00000002466.9 Nr2f6 ENSMUST00000002466.9 nuclear receptor subfamily 2, group F, member 6, transcript variant 3 (from RefSeq NR_184449.1) ENSMUST00000002466.1 ENSMUST00000002466.2 ENSMUST00000002466.3 ENSMUST00000002466.4 ENSMUST00000002466.5 ENSMUST00000002466.6 ENSMUST00000002466.7 ENSMUST00000002466.8 Ear-2 Ear2 Erbal2 NR2F6_MOUSE NR_184449 P43136 Q61504 Q922G8 uc009mcx.1 uc009mcx.2 uc009mcx.3 Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin- choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine- dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Binds DNA as dimer; homodimer and heterodimer with NR2F2 and probably NR2F1. Interacts with THRB (By similarity). P43136; O35626: Rasd1; NbExp=5; IntAct=EBI-4319956, EBI-4319979; Nucleus Initially expressed at 8.5 dpc in the developing rhombencephalon. At 11.5 dpc expression in the CNS rapidly decreases and in newborn and adult expression is not detectable in the brain with the exceptions of Purkinje neurons and the choroid plexi. Reduction of neurons in the locus coerulus of the developing cortex. Defects in circadian behavior. Hyperreactive lymphocytes, late-onset immunopathology and hypersusceptibility to Th17-dependent experimental autoimmune encephalomyelitis. Belongs to the nuclear hormone receptor family. NR2 subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter zinc ion binding cell differentiation entrainment of circadian clock by photoperiod steroid hormone mediated signaling pathway sequence-specific DNA binding metal ion binding neuron development anatomical structure development detection of temperature stimulus involved in sensory perception of pain uc009mcx.1 uc009mcx.2 uc009mcx.3 
ENSMUST00000002469.9 Ocel1 ENSMUST00000002469.9 occludin/ELL domain containing 1, transcript variant 1 (from RefSeq NM_029865.2) ENSMUST00000002469.1 ENSMUST00000002469.2 ENSMUST00000002469.3 ENSMUST00000002469.4 ENSMUST00000002469.5 ENSMUST00000002469.6 ENSMUST00000002469.7 ENSMUST00000002469.8 G5E815 G5E815_MOUSE NM_029865 Ocel1 uc009mcu.1 uc009mcu.2 uc009mcu.3 uc009mcu.4 Belongs to the ELL/occludin family. uc009mcu.1 uc009mcu.2 uc009mcu.3 uc009mcu.4 
ENSMUST00000002473.10 Babam1 ENSMUST00000002473.10 BRISC and BRCA1 A complex member 1 (from RefSeq NM_026636.2) BABA1_MOUSE ENSMUST00000002473.1 ENSMUST00000002473.2 ENSMUST00000002473.3 ENSMUST00000002473.4 ENSMUST00000002473.5 ENSMUST00000002473.6 ENSMUST00000002473.7 ENSMUST00000002473.8 ENSMUST00000002473.9 Merit40 NM_026636 Nba1 Q3UI43 Q8C5Q8 Q99JU2 Q9CTJ4 uc009mdb.1 uc009mdb.2 uc009mdb.3 uc009mdb.4 Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. Cytoplasm Nucleus Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes. Belongs to the BABAM1 family. molecular_function nucleus cytoplasm cytosol DNA repair double-strand break repair chromatin organization cellular response to DNA damage stimulus cell cycle response to ionizing radiation nuclear body positive regulation of DNA repair cell division BRCA1-A complex protein K63-linked deubiquitination BRISC complex hematopoietic stem cell proliferation signal transduction involved in G2 DNA damage checkpoint uc009mdb.1 uc009mdb.2 uc009mdb.3 uc009mdb.4 
ENSMUST00000002487.15 Braf ENSMUST00000002487.15 Braf transforming gene (from RefSeq NM_139294.5) B-raf BRAF_MOUSE Braf E9QNG9 ENSMUST00000002487.1 ENSMUST00000002487.10 ENSMUST00000002487.11 ENSMUST00000002487.12 ENSMUST00000002487.13 ENSMUST00000002487.14 ENSMUST00000002487.2 ENSMUST00000002487.3 ENSMUST00000002487.4 ENSMUST00000002487.5 ENSMUST00000002487.6 ENSMUST00000002487.7 ENSMUST00000002487.8 ENSMUST00000002487.9 F6SZ47 NM_139294 P28028 Q3USE9 uc009bme.1 uc009bme.2 uc009bme.3 Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway. Phosphorylates PFKFB2 (By similarity). May play a role in the postsynaptic responses of hippocampal neurons. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; In quiescent cells, maintained in an inactive state via an intramolecular interaction between the protein kinase and N-terminal domains. Following mitogen-mediated cell activation, binds via its RGB domain to active HRAS (GTP-bound) which releases the inhibitory intramolecular interaction between the two domains. This allows the MAP2K1-mediated dimerization of KSR1 or KSR2, and BRAF which activates BRAF. Monomer (By similarity). Homodimer (By similarity). Heterodimerizes with RAF1, and the heterodimer possesses a highly increased kinase activity compared to the respective homodimers or monomers (By similarity). Heterodimerization is mitogen-regulated and enhanced by 14-3-3 proteins. MAPK1/ERK2 activation can induce a negative feedback that promotes the dissociation of the heterodimer by phosphorylating BRAF at Thr-738. Heterodimerizes (via N-terminus) with KSR1 (via N-terminus) or KSR2 (via N-terminus) in a MAP2K1-dependent manner (By similarity). Interacts with MAP2K1 and MAP2K2 (By similarity). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14. Interacts with RIT1. Interacts (via N-terminus) with RGS14 (via RBD domains); the interaction mediates the formation of a ternary complex with RAF1, a ternary complex inhibited by GNAI1 (By similarity). Interacts with DGKH (By similarity). Interacts with PRMT5 (By similarity). Interacts with AKAP13, MAP2K1 and KSR1. Identified in a complex with AKAP13, KSR1 and MAP2K1 (PubMed:21102438). Interacts with FNIP1 and FNIP2 (By similarity). P28028; Q99N57: Raf1; NbExp=2; IntAct=EBI-2584830, EBI-397757; P28028; P01111: NRAS; Xeno; NbExp=2; IntAct=EBI-2584830, EBI-721993; Nucleus Cytoplasm Cell membrane Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. Event=Alternative splicing; Named isoforms=2; Name=3; IsoId=P28028-3; Sequence=Displayed; Name=1; IsoId=P28028-1; Sequence=VSP_060878, VSP_060879, VSP_060880; Phosphorylation at Ser-348 by SGK1 inhibits its activity. Methylation by PRMT5 decreases stability and kinase activity. Ubiquitinated by RNF149; which leads to proteasomal degradation. Polyubiquitinated at Lys-615 in response to EGF (By similarity). Note=Participates in a chromosomal translocation that produces a Tif1a-BRAF (T18) oncogene originally isolated from a furfural-induced hepatoma. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. Sequence=AAA37320.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence=; MAPK cascade nucleotide binding activation of MAPKK activity myeloid progenitor cell differentiation protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity calcium ion binding protein binding ATP binding nucleus cytoplasm mitochondrion cytosol plasma membrane protein phosphorylation signal transduction visual learning positive regulation of gene expression negative regulation of fibroblast migration positive regulation of glucose transport membrane kinase activity phosphorylation transferase activity Ras GTPase binding cell differentiation thyroid gland development mitogen-activated protein kinase kinase binding positive regulation of peptidyl-serine phosphorylation somatic stem cell population maintenance intracellular signal transduction cellular response to drug regulation of cell proliferation identical protein binding neuron projection negative regulation of apoptotic process intracellular membrane-bounded organelle CD4-positive, alpha-beta T cell differentiation positive T cell selection CD4-positive or CD8-positive, alpha-beta T cell lineage commitment response to peptide hormone negative regulation of neuron apoptotic process cell body regulation of T cell differentiation alpha-beta T cell differentiation metal ion binding protein heterodimerization activity thymus development regulation of axon regeneration positive regulation of axon regeneration positive regulation of axonogenesis T cell receptor signaling pathway protein heterooligomerization positive regulation of stress fiber assembly response to cAMP long-term synaptic potentiation head morphogenesis face development positive regulation of ERK1 and ERK2 cascade trehalose metabolism in response to stress cellular response to calcium ion establishment of protein localization to membrane positive regulation of substrate adhesion-dependent cell spreading cellular response to nerve growth factor stimulus negative regulation of synaptic vesicle exocytosis negative regulation of endothelial cell apoptotic process uc009bme.1 uc009bme.2 uc009bme.3 
ENSMUST00000002495.18 Meis3 ENSMUST00000002495.18 Meis homeobox 3, transcript variant 1 (from RefSeq NM_008627.5) ENSMUST00000002495.1 ENSMUST00000002495.10 ENSMUST00000002495.11 ENSMUST00000002495.12 ENSMUST00000002495.13 ENSMUST00000002495.14 ENSMUST00000002495.15 ENSMUST00000002495.16 ENSMUST00000002495.17 ENSMUST00000002495.2 ENSMUST00000002495.3 ENSMUST00000002495.4 ENSMUST00000002495.5 ENSMUST00000002495.6 ENSMUST00000002495.7 ENSMUST00000002495.8 ENSMUST00000002495.9 MEIS3_MOUSE Mrg2 NM_008627 P97368 Q149R5 Q99L81 uc009fha.1 uc009fha.2 uc009fha.3 uc009fha.4 uc009fha.5 uc009fha.6 The protein encoding this gene belongs to the three amino acid loop extension family of homeodomain transcription factors, which play essential roles in many embryonic processes. These proteins are characterized by an atypical homeodomain containing a three amino acid loop extension between helices 1 and 2. Expression of this gene begins during the compaction stage of embryogenesis and continues into the blastocyst stage. This gene is also expressed in pancreatic islet cells and beta-cells and regulates beta-cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]. Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P97368-1; Sequence=Displayed; Name=2; IsoId=P97368-2; Sequence=VSP_012894; Expressed at high levels in the brain. Significant expression also observed in the heart, spleen and lung. Expressed in pancreatic islets (beta-cells and non-beta-cells) (PubMed:21059917). Not expressed until 11 days in embryonic development. Belongs to the TALE/MEIS homeobox family. transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter positive regulation of protein kinase B signaling negative regulation of apoptotic signaling pathway uc009fha.1 uc009fha.2 uc009fha.3 uc009fha.4 uc009fha.5 uc009fha.6 
ENSMUST00000002502.12 Hltf ENSMUST00000002502.12 helicase-like transcription factor, transcript variant 1 (from RefSeq NM_009210.3) ENSMUST00000002502.1 ENSMUST00000002502.10 ENSMUST00000002502.11 ENSMUST00000002502.2 ENSMUST00000002502.3 ENSMUST00000002502.4 ENSMUST00000002502.5 ENSMUST00000002502.6 ENSMUST00000002502.7 ENSMUST00000002502.8 ENSMUST00000002502.9 HLTF_MOUSE NM_009210 O35596 O35597 Q6PCN7 Q80VT6 Smarca3 Snf2l3 Zbu1 uc008osl.1 uc008osl.2 uc008osl.3 uc008osl.4 Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'- linked polyubiquitination of chromatin-bound PCNA (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with SP1 and SP3 independently of DNA; the interaction with these transcriptional factors may be required for basal transcription of target genes. Interacts with EGR1; the interaction requires prior binding to DNA and represses c-Rel via a DNA looping mechanism. Interacts with GATA4. Interacts with PCNA; the interaction promotes polyubiquitination of PCNA through association with the UBE2B-RAD18 and UBE2V2-UBE2N ubiquitin ligase complexes. Interacts with RAD18, SHPRH, UBE2V2 and UBE2N (By similarity). Cytoplasm Nucleus Nucleus, nucleolus Nucleus, nucleoplasm Note=Nuclear localization is stimulated by progesterone. Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. Expressed in the heart from 11.5 dpc. Gradually increases in skeletal muscle to 18.5 dpc. Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily. Sequence=AAB63915.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; nucleotide binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding catalytic activity helicase activity ATP binding nucleus nucleoplasm nucleolus cytoplasm chromatin organization DNA-dependent ATPase activity metabolic process zinc ion binding protein ubiquitination transferase activity hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ubiquitin protein ligase binding positive regulation of transcription from RNA polymerase II promoter metal ion binding ubiquitin protein ligase activity uc008osl.1 uc008osl.2 uc008osl.3 uc008osl.4 
ENSMUST00000002518.9 Tle5 ENSMUST00000002518.9 TLE family member 5, transcriptional modulator, transcript variant 3 (from RefSeq NR_074087.1) Aes ENSMUST00000002518.1 ENSMUST00000002518.2 ENSMUST00000002518.3 ENSMUST00000002518.4 ENSMUST00000002518.5 ENSMUST00000002518.6 ENSMUST00000002518.7 ENSMUST00000002518.8 NR_074087 Q3TYD9 Q3TYD9_MOUSE Tle5 uc007gim.1 uc007gim.2 uc007gim.3 uc007gim.4 This gene encodes a protein that belongs to the Aes (amino-terminal enhancer of split) subgroup of the Groucho/transducin-like Enhancer of split (TLE) family of proteins that function as transcriptional corepressors. The encoded protein plays a role in neurological development and cell-fate determination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2013]. Nucleus Belongs to the WD repeat Groucho/TLE family. negative regulation of transcription from RNA polymerase II promoter transcription corepressor activity nucleus regulation of transcription, DNA-templated negative regulation of gene expression negative regulation of protein binding negative regulation of transcription, DNA-templated negative regulation of response to cytokine stimulus response to interleukin-1 negative regulation of canonical Wnt signaling pathway positive regulation of anoikis uc007gim.1 uc007gim.2 uc007gim.3 uc007gim.4 
ENSMUST00000002529.7 Prpf6 ENSMUST00000002529.7 pre-mRNA splicing factor 6 (from RefSeq NM_133701.2) ENSMUST00000002529.1 ENSMUST00000002529.2 ENSMUST00000002529.3 ENSMUST00000002529.4 ENSMUST00000002529.5 ENSMUST00000002529.6 NM_133701 PRP6_MOUSE Q3ULJ7 Q542P0 Q8CIK9 Q8R3M8 Q91YR7 Q99JN1 Q9CSZ0 uc008omz.1 uc008omz.2 uc008omz.3 Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Identified in the spliceosome B complex. Identified in the spliceosome C complex. Associates with the U5 snRNP particle. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, LSm proteins LSm2-8 and Sm proteins. Interacts with ARAF1. Interacts with AR and NR3C1, but not ESR1, independently of the presence of hormones. Interacts with USH1G. Nucleus, nucleoplasm Nucleus speckle Note=Localized in splicing speckles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91YR7-1; Sequence=Displayed; Name=2; IsoId=Q91YR7-2; Sequence=VSP_002063, VSP_002064; spliceosomal tri-snRNP complex assembly mRNA splicing, via spliceosome transcription coactivator activity RNA binding nucleus nucleoplasm spliceosomal complex U5 snRNP RNA processing mRNA processing RNA localization RNA splicing nuclear speck ribonucleoprotein complex binding positive regulation of transcription from RNA polymerase II promoter U4/U6 x U5 tri-snRNP complex androgen receptor binding U2-type precatalytic spliceosome catalytic step 2 spliceosome uc008omz.1 uc008omz.2 uc008omz.3 
ENSMUST00000002533.15 Rgs20 ENSMUST00000002533.15 regulator of G-protein signaling 20, transcript variant 2 (from RefSeq NM_021374.5) ENSMUST00000002533.1 ENSMUST00000002533.10 ENSMUST00000002533.11 ENSMUST00000002533.12 ENSMUST00000002533.13 ENSMUST00000002533.14 ENSMUST00000002533.2 ENSMUST00000002533.3 ENSMUST00000002533.4 ENSMUST00000002533.5 ENSMUST00000002533.6 ENSMUST00000002533.7 ENSMUST00000002533.8 ENSMUST00000002533.9 NM_021374 Q14A97 Q3TY63 Q9CUV8 Q9QZB1 Q9QZB2 RGS20_MOUSE Rgsz1 uc007afk.1 uc007afk.2 uc007afk.3 uc007afk.4 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)- i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results in mu-opioid receptor desensitization. Interacts with OPRM1 (By similarity). Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus Anchored to the membrane through palmitoylation. Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity). N- and O-glycosylated in synapsomal membranes. Serine phosphorylated in synapsomal membranes. Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation increases binding to the G-proteins, G(alpha)-i2 and G(z), and interaction with mu-opioid receptors. Sequence=BAB28987.2; Type=Erroneous initiation; Evidence=; GTPase activator activity nucleus cytoplasm Golgi apparatus trans-Golgi network G-protein coupled receptor signaling pathway negative regulation of signal transduction membrane positive regulation of GTPase activity uc007afk.1 uc007afk.2 uc007afk.3 uc007afk.4 
ENSMUST00000002551.5 Snrpd1 ENSMUST00000002551.5 small nuclear ribonucleoprotein D1 (from RefSeq NM_009226.4) ENSMUST00000002551.1 ENSMUST00000002551.2 ENSMUST00000002551.3 ENSMUST00000002551.4 NM_009226 P13641 P62315 Q3UYM0 SMD1_MOUSE uc008eaz.1 uc008eaz.2 uc008eaz.3 Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct. Cytoplasm, cytosol Nucleus Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs. Belongs to the snRNP core protein family. commitment complex spliceosomal snRNP assembly mRNA splicing, via spliceosome RNA binding nucleus spliceosomal complex U5 snRNP U1 snRNP U2 snRNP U4 snRNP U12-type spliceosomal complex cytoplasm cytosol RNA processing mRNA processing RNA splicing methylosome pICln-Sm protein complex SMN-Sm protein complex U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome U1 snRNP binding uc008eaz.1 uc008eaz.2 uc008eaz.3 
ENSMUST00000002572.6 Nherf2 ENSMUST00000002572.6 NHERF family PDZ scaffold protein 2, transcript variant A (from RefSeq NM_023055.2) A0A0R4IZX2 A0A0R4IZX2_MOUSE ENSMUST00000002572.1 ENSMUST00000002572.2 ENSMUST00000002572.3 ENSMUST00000002572.4 ENSMUST00000002572.5 NM_023055 Nherf2 Slc9a3r2 uc008axk.1 uc008axk.2 uc008axk.3 uc008axk.4 Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Cell membrane Endomembrane system eripheral membrane protein receptor binding plasma membrane beta-catenin binding protein C-terminus binding endomembrane system membrane phosphatase binding binding, bridging uc008axk.1 uc008axk.2 uc008axk.3 uc008axk.4 
ENSMUST00000002599.11 Puf60 ENSMUST00000002599.11 poly-U binding splicing factor 60, transcript variant 2 (from RefSeq NM_133691.6) ENSMUST00000002599.1 ENSMUST00000002599.10 ENSMUST00000002599.2 ENSMUST00000002599.3 ENSMUST00000002599.4 ENSMUST00000002599.5 ENSMUST00000002599.6 ENSMUST00000002599.7 ENSMUST00000002599.8 ENSMUST00000002599.9 NM_133691 PUF60_MOUSE Puf60 Q3TGC6 Q3UEB3 Q91VR6 Siahbp1 uc007wik.1 uc007wik.2 uc007wik.3 uc007wik.4 DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA (By similarity). Homodimer (By similarity). Associates with the spliceosome (By similarity). Found in a complex with RO60 and Y5 RNA (By similarity). Found in a complex with FUBP1 and far upstream element (FUSE) DNA segment (By similarity). Interacts directly with ERCC3. Interacts with CDK7 and GTF2H1 (By similarity). Interacts with SRSF11/P54 (By similarity). Nucleus Note=Colocalizes partially with RO60. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UEB3-1; Sequence=Displayed; Name=2; IsoId=Q3UEB3-2; Sequence=VSP_027721; Name=3; IsoId=Q3UEB3-3; Sequence=VSP_027720, VSP_027721; The third RNA recognition motif, called PUMP domain, is atypical and may rather mediate homodimerization and/or protein-protein interactions. Belongs to the RRM half pint family. nucleic acid binding DNA binding RNA binding nucleus nucleoplasm mRNA processing apoptotic process RNA splicing cell junction identical protein binding uc007wik.1 uc007wik.2 uc007wik.3 uc007wik.4 
ENSMUST00000002603.12 Scrib ENSMUST00000002603.12 scribbled planar cell polarity, transcript variant 1 (from RefSeq NM_134089.2) ENSMUST00000002603.1 ENSMUST00000002603.10 ENSMUST00000002603.11 ENSMUST00000002603.2 ENSMUST00000002603.3 ENSMUST00000002603.4 ENSMUST00000002603.5 ENSMUST00000002603.6 ENSMUST00000002603.7 ENSMUST00000002603.8 ENSMUST00000002603.9 Kiaa0147 Lap4 NM_134089 Q6P5H7 Q7TPH8 Q80U72 Q80VB1 Q8CI48 Q8VII1 Q922S3 SCRIB_MOUSE Scrib1 uc007wig.1 uc007wig.2 uc007wig.3 uc007wig.4 Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:12499390, PubMed:18716323, PubMed:19041750, PubMed:18329370). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (PubMed:18329370). Most probably functions in the establishment of apico-basal cell polarity (PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:19041750). May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling (PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:19458197). Functions as an activator of Rac GTPase activity. Interacts with UBE3A (By similarity). Interacts with PAK1 and PAK2 (PubMed:18716323). Interacts (via PDZ domains) with VANGL2 (PubMed:16687519). Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct (By similarity). Interacts (via PDZ domains) with TJP2 (By similarity). Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells (PubMed:16611247). Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function (By similarity). Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7 (PubMed:15182672). Interacts with CTNNB1 (PubMed:16611247, PubMed:19458197). Interacts with MAPK12 (PubMed:15878399). Interacts (via PDZ domains 1 and 3) with MCC (By similarity). Interacts with DLG5 (By similarity). Interacts with STK4/MST1 and LATS1 in the presence of DLG5 (By similarity). Interacts (via PDZ domain 3) with CRTAM (via PDZ-binding motif); the interaction promotes CRTAM and SCRIB polarization in a subset of CD4+ T-cells (PubMed:18329370). Q80U72; Q149L7: Crtam; NbExp=4; IntAct=EBI-1766028, EBI-1766072; Q80U72; O60346: PHLPP1; Xeno; NbExp=2; IntAct=EBI-1766028, EBI-2511516; Cell membrane ; Peripheral membrane protein Cell junction Cell junction, adherens junction Cell projection, lamellipodium Cytoplasm Postsynapse Presynapse Note=Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity (By similarity). In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (PubMed:18329370). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80U72-1; Sequence=Displayed; Name=2; IsoId=Q80U72-2; Sequence=VSP_010911; Name=3; IsoId=Q80U72-3; Sequence=VSP_010910, VSP_010911; Name=4; IsoId=Q80U72-4; Sequence=VSP_010909, VSP_010910; Expressed in CD4+ T-cells (at protein level) (PubMed:18329370). Found in a wide range of tissues including liver, kidney and spleen (PubMed:15806148). Also expressed in the brain (at protein level) (PubMed:15182672, PubMed:15806148). First detected at 7.5 dpc in the neuroepithelium at the time of initial neural tube closure. Also expressed in cranial mesenchyme, branchial arches, somitic mesoderm and lateral mesoderm. At later stages it is expressed in the eyelid epithelium, submandibular glands, whisker and hair follicles, sympathetic glanglia, inner ear, thymus, testis, kidney, esophagus, lung, stomach, trigeminal and dorsal root glanglia. Ubiquitinated; targeted for UBE3A-dependent multiubiquitination and degraded. Palmitoylated. Could be depalmitoylated by LYPLA1 and/or LYPLA2. Palmitoylation of SCRIB by ZDHHC7 is required for its localization to cell-cell junctions, function in the establishement of epithelial cell polarity and the regulation of downstream signaling pathways important for epithelial cell differentiation. The circletail (Crc) mice exhibit craniorachischisis, a severe form of neural tube defect. This is due to a single base insertion in the Scrib gene creating a frameshift which leads to synthesis of a truncated protein. Belongs to the LAP (LRR and PDZ) protein family. Sequence=BAC65493.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; neural tube closure positive regulation of receptor recycling auditory receptor cell morphogenesis epithelial cell morphogenesis protein binding nucleoplasm cytoplasm cytosol plasma membrane cell-cell junction adherens junction cell-cell adherens junction multicellular organism development protein localization cell proliferation postsynaptic density membrane synaptic vesicle targeting basolateral plasma membrane apical plasma membrane morphogenesis of embryonic epithelium cell migration cochlear nucleus development lamellipodium cell junction cell differentiation cell leading edge Scrib-APC-beta-catenin complex establishment of apical/basal cell polarity ionotropic glutamate receptor binding myelin sheath abaxonal region post-anal tail morphogenesis wound healing presynaptic membrane cell projection positive regulation of apoptotic process receptor clustering astrocyte cell migration cell-cell contact zone establishment or maintenance of epithelial cell apical/basal polarity synapse postsynaptic membrane negative regulation of mitotic cell cycle synaptic vesicle endocytosis camera-type eye morphogenesis positive chemotaxis auditory receptor cell stereocilium organization inner ear receptor stereocilium organization apoptotic process involved in morphogenesis mammary gland duct morphogenesis protein localization to adherens junction activation of GTPase activity receptor localization to synapse cell-cell adhesion neurotransmitter receptor transport, endosome to postsynaptic membrane neurotransmitter receptor transport postsynaptic membrane to endosome glutamatergic synapse vesicle-mediated transport in synapse ionotropic glutamate receptor complex uc007wig.1 uc007wig.2 uc007wig.3 uc007wig.4 
ENSMUST00000002625.15 Uck1 ENSMUST00000002625.15 uridine-cytidine kinase 1, transcript variant 3 (from RefSeq NM_011675.2) A2AN37 A2AN37_MOUSE ENSMUST00000002625.1 ENSMUST00000002625.10 ENSMUST00000002625.11 ENSMUST00000002625.12 ENSMUST00000002625.13 ENSMUST00000002625.14 ENSMUST00000002625.2 ENSMUST00000002625.3 ENSMUST00000002625.4 ENSMUST00000002625.5 ENSMUST00000002625.6 ENSMUST00000002625.7 ENSMUST00000002625.8 ENSMUST00000002625.9 NM_011675 Uck1 uc008jes.1 uc008jes.2 uc008jes.3 uc008jes.4 Reaction=ATP + cytidine = ADP + CMP + H(+); Xref=Rhea:RHEA:24674, ChEBI:CHEBI:15378, ChEBI:CHEBI:17562, ChEBI:CHEBI:30616, ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.1.48; Evidence= Reaction=ATP + uridine = ADP + H(+) + UMP; Xref=Rhea:RHEA:16825, ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:30616, ChEBI:CHEBI:57865, ChEBI:CHEBI:456216; EC=2.7.1.48; Evidence= Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. Belongs to the uridine kinase family. nucleotide binding uridine kinase activity ATP binding kinase activity phosphorylation transferase activity nucleoside kinase activity UMP salvage CTP salvage uc008jes.1 uc008jes.2 uc008jes.3 uc008jes.4 
ENSMUST00000002640.6 Scin ENSMUST00000002640.6 scinderin, transcript variant 1 (from RefSeq NM_001146196.1) ENSMUST00000002640.1 ENSMUST00000002640.2 ENSMUST00000002640.3 ENSMUST00000002640.4 ENSMUST00000002640.5 NM_001146196 O08988 O08990 Q60604 Q6P4N8 SCIN_MOUSE uc007nkw.1 uc007nkw.2 uc007nkw.3 uc007nkw.4 uc007nkw.5 Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:9671468). Severing activity is inhibited by phosphatidylinositol 4,5-bis- phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+) (PubMed:9671468). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (PubMed:25275604, PubMed:25681458). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (By similarity). [Isoform 2]: Fails to nucleate actin polymerization, although it severs and caps actin filaments in a Ca(2+)-dependent manner. Cytoplasm, cytoskeleton Cell projection, podosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60604-1; Sequence=Displayed; Name=2; Synonyms=D5 ; IsoId=Q60604-2; Sequence=VSP_006730; Ubiquitous. Highly expressed in mature osteoclasts (at protein level) (PubMed:25275604). Isoform 2 is expressed in blood cells (PubMed:9671468). Expression is induced during osteoclastogenesis. Knockdown in bone marrow monocytes protect mice from bone resorption in periodontal disease model. Belongs to the villin/gelsolin family. podosome actin binding calcium ion binding cytoplasm cytoskeleton plasma membrane brush border negative regulation of cell proliferation cell junction regulation of chondrocyte differentiation macromolecular complex sequestering of actin monomers cell projection positive regulation of apoptotic process positive regulation of megakaryocyte differentiation metal ion binding actin filament severing actin filament binding positive regulation of actin nucleation actin filament capping uc007nkw.1 uc007nkw.2 uc007nkw.3 uc007nkw.4 uc007nkw.5 
ENSMUST00000002655.8 Mien1 ENSMUST00000002655.8 migration and invasion enhancer 1 (from RefSeq NM_025559.2) A2A556 ENSMUST00000002655.1 ENSMUST00000002655.2 ENSMUST00000002655.3 ENSMUST00000002655.4 ENSMUST00000002655.5 ENSMUST00000002655.6 ENSMUST00000002655.7 MIEN1_MOUSE NM_025559 Q9CQ86 Rdx12 uc007lgj.1 uc007lgj.2 uc007lgj.3 Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity). Interacts with GPX1. Cytoplasm, cytosol Cell membrane ; Lipid-anchor ; Cytoplasmic side Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions (By similarity). Widely expressed with highest levels in kidney followed by brain and testis. Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation. Belongs to the SelWTH family. protein binding cytoplasm cytosol plasma membrane apoptotic process membrane positive regulation of cell migration intrinsic component of the cytoplasmic side of the plasma membrane negative regulation of apoptotic process positive regulation of filopodium assembly uc007lgj.1 uc007lgj.2 uc007lgj.3 
ENSMUST00000002663.12 Pon1 ENSMUST00000002663.12 paraoxonase 1, transcript variant 1 (from RefSeq NM_011134.4) ENSMUST00000002663.1 ENSMUST00000002663.10 ENSMUST00000002663.11 ENSMUST00000002663.2 ENSMUST00000002663.3 ENSMUST00000002663.4 ENSMUST00000002663.5 ENSMUST00000002663.6 ENSMUST00000002663.7 ENSMUST00000002663.8 ENSMUST00000002663.9 NM_011134 P52430 PON1_MOUSE Pon Q91X30 uc009awd.1 uc009awd.2 uc009awd.3 Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification. Reaction=a phenyl acetate + H2O = a phenol + acetate + H(+); Xref=Rhea:RHEA:17309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:33853, ChEBI:CHEBI:140310; EC=3.1.1.2; Evidence=; Reaction=An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.; EC=3.1.8.1; Evidence=; Reaction=an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H(+); Xref=Rhea:RHEA:22576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:55474, ChEBI:CHEBI:58921; EC=3.1.1.81; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 calcium ions per subunit. ; Homodimer. Interacts with CLU. Secreted, extracellular space. Plasma, liver, kidney, heart, brain, small intestine and lung. In the plasma, associated with HDL. The signal sequence is not cleaved. The preferential association of PON1 with HDL is mediated in part by its signal peptide, by binding phospholipids directly, rather than binding apo AI. The retained signal peptide may allow transfer of the protein between phospholipid surfaces. Belongs to the paraoxonase family. aryldialkylphosphatase activity arylesterase activity calcium ion binding phospholipid binding extracellular region extracellular space lipid metabolic process blood circulation high-density lipoprotein particle binding cholesterol metabolic process response to toxic substance positive regulation of cholesterol efflux dephosphorylation hydrolase activity aromatic compound catabolic process response to nutrient levels positive regulation of transporter activity high-density lipoprotein particle spherical high-density lipoprotein particle protein homodimerization activity intracellular membrane-bounded organelle carboxylic acid catabolic process organophosphate catabolic process phosphatidylcholine metabolic process metal ion binding positive regulation of binding response to fatty acid acyl-L-homoserine-lactone lactonohydrolase activity response to fluoride uc009awd.1 uc009awd.2 uc009awd.3 
ENSMUST00000002677.11 Axl ENSMUST00000002677.11 AXL receptor tyrosine kinase, transcript variant 1 (from RefSeq NM_009465.4) Ark ENSMUST00000002677.1 ENSMUST00000002677.10 ENSMUST00000002677.2 ENSMUST00000002677.3 ENSMUST00000002677.4 ENSMUST00000002677.5 ENSMUST00000002677.6 ENSMUST00000002677.7 ENSMUST00000002677.8 ENSMUST00000002677.9 NM_009465 Q00993 Q80YQ3 UFO_MOUSE Ufo uc009ftx.1 uc009ftx.2 uc009ftx.3 uc009ftx.4 Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Activated by GAS6-binding and subsequent autophosphorylation. Heterodimer and heterotetramer with ligand GAS6 (By similarity). Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TNS2. Part of a complex including AXL, TNK2 and GRB2, in which GRB2 promotes AXL recruitment by TNK2 (By similarity). Cell membrane ; Single-pass type I membrane protein In distinct substructures of a broad spectrum of developing tissues (in the late embryogenesis). In cells forming organ capsules as well as in connective tissue structures (in adult). Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion (By similarity). Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. nucleotide binding neuron migration natural killer cell differentiation phosphatidylserine binding negative regulation of cytokine production positive regulation of cytokine-mediated signaling pathway blood vessel remodeling immune system process protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding extracellular space plasma membrane integral component of plasma membrane protein phosphorylation phagocytosis inflammatory response enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway spermatogenesis nervous system development cell surface membrane integral component of membrane kinase activity phosphorylation cell migration transferase activity peptidyl-tyrosine phosphorylation forebrain cell migration cell differentiation platelet activation animal organ regeneration cellular response to extracellular stimulus myosin heavy chain binding negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of natural killer cell differentiation secretion by cell erythrocyte homeostasis substrate adhesion-dependent cell spreading cellular response to interferon-alpha ovulation cycle negative regulation of apoptotic process receptor complex apoptotic cell clearance protein kinase B signaling negative regulation of neuron apoptotic process phosphatidylinositol 3-kinase binding host cell surface innate immune response viral entry into host cell protein heterodimerization activity cell maturation positive regulation of pinocytosis negative regulation of lymphocyte activation positive regulation of protein kinase B signaling vagina development cellular response to hydrogen peroxide cellular response to lipopolysaccharide dendritic cell differentiation neutrophil clearance negative regulation of dendritic cell apoptotic process uc009ftx.1 uc009ftx.2 uc009ftx.3 uc009ftx.4 
ENSMUST00000002678.10 Tgfb1 ENSMUST00000002678.10 transforming growth factor, beta 1 (from RefSeq NM_011577.2) ENSMUST00000002678.1 ENSMUST00000002678.2 ENSMUST00000002678.3 ENSMUST00000002678.4 ENSMUST00000002678.5 ENSMUST00000002678.6 ENSMUST00000002678.7 ENSMUST00000002678.8 ENSMUST00000002678.9 NM_011577 Q3UNK5 Q3UNK5_MOUSE Tgfb1 uc009ftq.1 uc009ftq.2 uc009ftq.3 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. Mice lacking a functional copy of this gene develop severe multifocal inflammatory disease, yolk sac defects and colon cancer. [provided by RefSeq, Aug 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ009862.1, AK144163.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Homodimer; disulfide-linked. Secreted, extracellular space, extracellular matrix Belongs to the TGF-beta family. MAPK cascade response to hypoxia morphogenesis of a branching structure epithelial to mesenchymal transition negative regulation of protein phosphorylation positive regulation of protein phosphorylation chondrocyte differentiation hematopoietic progenitor cell differentiation aortic valve morphogenesis antigen binding type II transforming growth factor beta receptor binding transforming growth factor beta receptor binding protein binding extracellular region extracellular space nucleus cytoplasm microvillus protein phosphorylation protein export from nucleus ATP biosynthetic process phosphate-containing compound metabolic process inflammatory response cell cycle arrest mitotic cell cycle checkpoint epidermal growth factor receptor signaling pathway transforming growth factor beta receptor signaling pathway common-partner SMAD protein phosphorylation SMAD protein complex assembly negative regulation of neuroblast proliferation salivary gland morphogenesis female pregnancy aging growth factor activity positive regulation of cell proliferation negative regulation of cell proliferation response to radiation response to wounding response to glucose defense response to fungus, incompatible interaction cell surface response to organic substance positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of fibroblast migration positive regulation of peptidyl-threonine phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of macrophage cytokine production response to organic cyclic compound cell migration regulation of transforming growth factor beta receptor signaling pathway evasion or tolerance of host defenses by virus enzyme binding negative regulation of cell-cell adhesion secretory granule hyaluronan catabolic process negative regulation of cell growth positive regulation of cell migration axon positive regulation of bone mineralization animal organ regeneration membrane protein intracellular domain proteolysis positive regulation of protein complex assembly positive regulation of exit from mitosis lipopolysaccharide-mediated signaling pathway positive regulation of cellular protein metabolic process response to estradiol response to progesterone positive regulation of interleukin-17 production receptor catabolic process positive regulation of superoxide anion generation positive regulation of collagen biosynthetic process positive regulation of peptidyl-serine phosphorylation response to vitamin D response to laminar fluid shear stress type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding positive regulation of protein dephosphorylation response to immobilization stress wound healing positive regulation of protein import into nucleus response to drug myelination identical protein binding protein homodimerization activity neuronal cell body positive regulation of apoptotic process positive regulation of vascular permeability positive regulation of MAP kinase activity protein kinase B signaling positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration positive regulation of phosphatidylinositol 3-kinase activity ossification involved in bone remodeling cell-cell junction organization negative regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of cytolysis negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein N-terminus binding positive regulation of isotype switching to IgA isotypes digestive tract development negative regulation of skeletal muscle tissue development inner ear development positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of protein secretion positive regulation of peptidyl-tyrosine phosphorylation negative regulation of phagocytosis negative regulation of immune response positive regulation of chemotaxis positive regulation of NF-kappaB transcription factor activity positive regulation of smooth muscle cell differentiation negative regulation of release of sequestered calcium ion into cytosol positive regulation of cell division positive regulation of protein kinase B signaling frontal suture morphogenesis pathway-restricted SMAD protein phosphorylation regulation of SMAD protein import into nucleus positive regulation of SMAD protein import into nucleus negative regulation of gene silencing by miRNA negative regulation of biomineral tissue development positive regulation of ERK1 and ERK2 cascade response to cholesterol cellular response to mechanical stimulus cellular response to organic cyclic compound cellular response to ionizing radiation cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus positive regulation of mononuclear cell migration blood microparticle extracellular matrix assembly positive regulation of branching involved in ureteric bud morphogenesis extrinsic apoptotic signaling pathway liver regeneration negative regulation of hyaluronan biosynthetic process positive regulation of protein localization to nucleus positive regulation of NAD+ ADP-ribosyltransferase activity response to salt positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of protein localization to plasma membrane negative regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of production of miRNAs involved in gene silencing by miRNA cellular response to insulin-like growth factor stimulus positive regulation of transcription regulatory region DNA binding positive regulation of cardiac muscle cell differentiation uc009ftq.1 uc009ftq.2 uc009ftq.3 
ENSMUST00000002683.3 Ccdc97 ENSMUST00000002683.3 coiled-coil domain containing 97, transcript variant 6 (from RefSeq NR_160796.1) CCD97_MOUSE D7Ertd462e ENSMUST00000002683.1 ENSMUST00000002683.2 NR_160796 Q922V3 Q9DBT3 uc009ftr.1 uc009ftr.2 uc009ftr.3 May play a role pre-mRNA splicing through the association with the splicing factor SF3B complex which is involved in branch-site recognition. Associates with splicing factor SF3B complex, involved in branch-site recognition. Nucleus molecular_function biological_process uc009ftr.1 uc009ftr.2 uc009ftr.3 
ENSMUST00000002699.7 Akap8 ENSMUST00000002699.7 A kinase anchor protein 8, transcript variant 1 (from RefSeq NM_019774.5) AKAP8_MOUSE Akap95 ENSMUST00000002699.1 ENSMUST00000002699.2 ENSMUST00000002699.3 ENSMUST00000002699.4 ENSMUST00000002699.5 ENSMUST00000002699.6 NM_019774 Q9DBR0 Q9R0L8 uc008bwg.1 uc008bwg.2 uc008bwg.3 uc008bwg.4 uc008bwg.5 This gene encodes a member of the A-kinase anchoring protein (AKAP) family. These proteins are characterized by their ability to bind to the R subunit of protein kinase A (PKA) and anchor the protein at different subcellular locations. This protein has been shown to regulate apoptosis and to be involved in palatogenesis. Knockdown of this gene has been associated with altered histone modifications and reduced expression of developmental genes in mouse embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (By similarity). Specifically involved in recruitment of CAPD2 to, and condensation of maternal but not paternal chromosomes (PubMed:12082153). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation. May be involved in regulation of DNA replication by acting as scaffold for MCM2. Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells. May act as a carrier protein of GJA1 for its transport to the nucleus. May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (By similarity). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (PubMed:19531803). Binds to the PKA RII-alpha regulatory subunit PRKAR2A (By similarity). Interacts (via C-terminus) with FIGN (PubMed:16751186). Interacts with NCAPD2, CCND3, CCNE1, MCM2, RPS6KA1, DDX5, PDE4A (By similarity). Interacts with MYCBP; MYCBP is translocated to the nucleus and the interaction prevents the association of the PKA catalytic subunit leading to suppression of PKA activity (PubMed:12414807). Interacts with CCND1, CASP3 (PubMed:14641107, PubMed:16227597). Interacts with NFKB1; detetcted in the cytoplasm (PubMed:19531803). Interacts with DPY30; mediating AKAP8 association with at least the MLL4/WBP7 HMT complex. Interacts with HDAC3; increased during mitosis. Interacts with GJA1; in the nucleus and in the nuclear membrane; the nuclear association increases with progress of cell cycle G1, S and G2 phase and decreases in M phase (By similarity). Q9DBR0; Q9ERZ6: Fign; NbExp=4; IntAct=EBI-4285802, EBI-11111349; Q9DBR0; P25799: Nfkb1; NbExp=4; IntAct=EBI-4285802, EBI-643958; Nucleus matrix Nucleus, nucleolus Cytoplasm Note=Associated with the nuclear matrix (By similarity). Exhibits partial localization to the nucleolus in interphase, possibly to the fibrillary center and/or to the dense fibrillary component (By similarity). Redistributed and detached from condensed chromatin during mitosis (By similarity). Localizes specifically to the vicinity of the meiotic spindle in metaphase II oocytes (PubMed:12082153). Weakly expressed in metaphase II oocytes. Strongly up-regulated after fertilization at the pronuclear stage and restricted to the female pronucleus. Subsequently localized to the nucleus of each blastomere and on condensed chromosomes in mitotic cells. Phosphorylated on tyrosine residues probably by SRC subfamily protein kinases; multiple phosphorylation is leading to dissociation from nuclear structures implicated in chromatin structural changes. AKAP8 and FIGN double mutant mice die soon after birth due to cleft palate. Belongs to the AKAP95 family. nuclear chromatin condensed chromosome female pronucleus immune system process DNA binding chromatin binding double-stranded DNA binding protein binding nucleus nucleoplasm nucleolus cytoplasm mitochondrion Golgi apparatus mitotic chromosome condensation zinc ion binding protein transport nuclear matrix positive regulation of histone deacetylation negative regulation of tumor necrosis factor production regulation of histone phosphorylation protein kinase A regulatory subunit binding histone deacetylase binding cell cycle G2/M phase transition innate immune response metal ion binding NF-kappaB binding cellular response to lipopolysaccharide cellular response to prostaglandin E stimulus uc008bwg.1 uc008bwg.2 uc008bwg.3 uc008bwg.4 uc008bwg.5 
ENSMUST00000002708.5 Shh ENSMUST00000002708.5 sonic hedgehog (from RefSeq NM_009170.3) ENSMUST00000002708.1 ENSMUST00000002708.2 ENSMUST00000002708.3 ENSMUST00000002708.4 Hhg1 NM_009170 Q62226 SHH_MOUSE Shh uc008wua.1 uc008wua.2 uc008wua.3 uc008wua.4 [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (PubMed:8824192, PubMed:7891723, PubMed:7736596). Both activities result in the cleavage of the full- length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (PubMed:8824192). Both activities occur in the reticulum endoplasmic (PubMed:21357747). Once cleaved, ShhC is degraded in the endoplasmic reticulum (PubMed:21357747). [Sonic hedgehog protein N-product]: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites (PubMed:11430830, PubMed:24863049). Involved in the patterning of the anterior-posterior axis of the developing limb bud (PubMed:15315762). Essential for axon guidance (PubMed:12679031). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity). In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (By similarity). [Sonic hedgehog protein]: Reaction=cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]- C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl- [protein]; Xref=Rhea:RHEA:59504, Rhea:RHEA-COMP:12707, Rhea:RHEA- COMP:15369, Rhea:RHEA-COMP:15374, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:65250, ChEBI:CHEBI:143135, ChEBI:CHEBI:143140; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59505; Evidence=; Interacts with HHATL/GUP1 which negatively regulates HHAT- mediated palmitoylation of the SHH N-terminus (PubMed:18081866). Interacts with BOC and CDON (PubMed:18794898). Interacts with HHIP (By similarity). Interacts with DISP1 via its cholesterol anchor (PubMed:22902404, PubMed:22677548). Interacts with SCUBE2 (PubMed:24522195, PubMed:22677548). Interacts with glypican GPC3 (PubMed:18477453). [Sonic hedgehog protein N-product]: Multimer. Q62226; Q4KMG0: CDON; Xeno; NbExp=7; IntAct=EBI-15610166, EBI-7016840; Q62226; Q96QV1-1: HHIP; Xeno; NbExp=4; IntAct=EBI-15610166, EBI-15791478; [Sonic hedgehog protein]: Endoplasmic reticulum membrane Golgi apparatus membrane Note=Co-localizes with HHAT in the ER and Golgi membrane. [Sonic hedgehog protein N-product]: Cell membrane ; Lipid-anchor Note=The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers (PubMed:24522195). Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by the proteolytic removal of both terminal lipidated peptides. Expressed in a number of embryonic tissues including the notochord, ventral neural tube, floor plate, lung bud, zone of polarizing activity and posterior distal mesenchyme of limbs. In the adult, expressed in lung and neural retina. First detectable during gastrulation. By retinoic acid. [Sonic hedgehog protein N-product]: Binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein- protein interactions mediated by this domain. [Sonic hedgehog protein N-product]: The Cardin-Weintraub (CW) motif is required for heparan sulfate binding of the solubilized ShhNp (PubMed:23118222). The N-terminal palmitoylated peptide is cleaved at the heparan sulfate-binding Cardin-Weintraub (CW) motif site (PubMed:24522195). The cleavage reduced the interactions with heparan sulfate. The cleavage is enhanced by SCUBE2 (PubMed:24522195). [Sonic hedgehog protein]: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity (PubMed:7891723, PubMed:7736596, PubMed:8824192). Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (ShhN)(PubMed:7891723, PubMed:7736596, PubMed:8824192). Cholesterylation is required for the sonic hedgehog protein N-product targeting to lipid rafts and multimerization (PubMed:24522195, PubMed:8824192). ShhN is the active species in both local and long-range signaling, whereas the C-product (ShhC) is degraded in the reticulum endoplasmic (PubMed:21357747). [Sonic hedgehog protein N-product]: N-palmitoylation by HHAT of ShhN is required for sonic hedgehog protein N-product multimerization and full activity (PubMed:11486055, PubMed:15075292). It is a prerequisite for the membrane-proximal positioning and the subsequent shedding of this N-terminal peptide (PubMed:24522195). [Sonic hedgehog protein N-product]: The lipidated N- and C- terminal peptides of ShhNp can be cleaved (shedding)(PubMed:24522195). The N-terminal palmitoylated peptide is cleaved at the Cardin-Weintraub (CW) motif site (PubMed:24522195). The cleavage reduced the interactions with heparan sulfate (PubMed:23118222). The cleavage is enhanced by SCUBE2. Mice overexpressing Shh display digit duplications in both forelimbs and hindlimbs. Belongs to the hedgehog family. The several steps and mechanisms that permit controlled Shh dispersion and gradient formation remain controversial. The ShhNC C- terminal domain displays an autoproteolysis activity and a cholesterol transferase activity resulting in the cleavage and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N- terminal fragment (ShhN). The protein is further modified by covalent addition of palmitate at the N-terminal of ShhN, resulting to the dual- lipidated Shh (ShhNp). ShhNp is firmly tethered to the cell membrane where it forms multimers. Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by proteolytic removal of both terminal lipidated peptides. Once released, the fully processed Shh can signal within embryonic tissues both at short and long-range. negative regulation of transcription from RNA polymerase II promoter angiogenesis branching involved in blood vessel morphogenesis vasculogenesis metanephros development branching involved in ureteric bud morphogenesis cell fate specification neural crest cell migration kidney development neural tube formation hair follicle development vasculature development heart looping positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation osteoblast development lymphoid progenitor cell differentiation determination of left/right asymmetry in lateral mesoderm patched binding calcium ion binding protein binding glycosaminoglycan binding extracellular region extracellular space nucleus endoplasmic reticulum Golgi apparatus plasma membrane regulation of transcription, DNA-templated proteolysis endocytosis signal transduction smoothened signaling pathway positive regulation of hh target transcription factor activity cell-cell signaling multicellular organism development determination of left/right symmetry pattern specification process ectoderm development neuroblast proliferation axon guidance central nervous system development hindgut morphogenesis digestive tract mesoderm development heart development blood coagulation synaptic vesicle androgen metabolic process zinc ion binding cell proliferation positive regulation of cell proliferation polarity specification of anterior/posterior axis anterior/posterior pattern specification dorsal/ventral pattern formation cell surface mesenchymal cell proliferation regulation of gene expression positive regulation of gene expression negative regulation of gene expression oligodendrocyte development striated muscle tissue development positive regulation of skeletal muscle cell proliferation myotube differentiation membrane intein-mediated protein splicing spinal cord dorsal/ventral patterning ventral spinal cord interneuron specification spinal cord motor neuron differentiation thalamus development forebrain regionalization dorsal/ventral neural tube patterning cell proliferation in external granule layer cerebellar granule cell precursor proliferation smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation positive regulation of cerebellar granule cell precursor proliferation telencephalon regionalization zona limitans intrathalamica formation establishment of cell polarity transport vesicle regulation of proteolysis positive regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway respiratory tube development lung development embryonic limb morphogenesis negative regulation of cell migration axon dendrite male genitalia development prostate gland development thyroid gland development forebrain development midbrain development hindbrain development extracellular matrix pancreas development hair follicle morphogenesis negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of neurotrophin production T cell differentiation in thymus positive regulation of T cell differentiation in thymus positive regulation of immature T cell proliferation in thymus negative regulation of transcription elongation from RNA polymerase II promoter protein localization to nucleus embryonic forelimb morphogenesis embryonic hindlimb morphogenesis regulation of cell proliferation negative regulation of T cell proliferation negative regulation of protein catabolic process positive regulation of protein import into nucleus odontogenesis of dentin-containing tooth odontogenesis regulation of odontogenesis embryonic digit morphogenesis camera-type eye development neuronal cell body negative regulation of apoptotic process laminin-1 binding CD4-positive or CD8-positive, alpha-beta T cell lineage commitment tongue development tongue morphogenesis skin development positive thymic T cell selection negative thymic T cell selection intermediate filament organization membrane raft cell fate commitment myoblast differentiation response to ethanol negative regulation of cell differentiation positive regulation of cell differentiation positive regulation of neuron differentiation positive regulation of smoothened signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of photoreceptor cell differentiation positive regulation of alpha-beta T cell differentiation negative regulation of alpha-beta T cell differentiation metal ion binding cell development thymus development digestive tract morphogenesis embryonic digestive tract morphogenesis embryonic organ development developmental growth embryonic morphogenesis embryonic foregut morphogenesis positive regulation of skeletal muscle tissue development animal organ formation anatomical structure formation involved in morphogenesis neuron fate commitment response to axon injury embryonic skeletal system development oligodendrocyte differentiation positive regulation of oligodendrocyte differentiation branching morphogenesis of an epithelial tube male genitalia morphogenesis inner ear development anatomical structure development formation of anatomical boundary stem cell development striated muscle cell differentiation positive regulation of striated muscle cell differentiation positive regulation of cell division Bergmann glial cell differentiation palate development canonical Wnt signaling pathway limb development limb bud formation positive regulation of penile erection lung morphogenesis lung epithelium development trachea development trachea morphogenesis epithelial tube branching involved in lung morphogenesis branching involved in prostate gland morphogenesis branching involved in salivary gland morphogenesis bud outgrowth involved in lung branching right lung development left lung development lung lobe morphogenesis lung-associated mesenchyme development primary prostatic bud elongation prostate epithelial cord elongation salivary gland cavitation epithelial cell proliferation involved in salivary gland morphogenesis epithelial-mesenchymal cell signaling regulation of prostatic bud formation epithelial-mesenchymal signaling involved in prostate gland development regulation of epithelial cell proliferation involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development regulation of mesenchymal cell proliferation involved in prostate gland development mesenchymal smoothened signaling pathway involved in prostate gland development artery development mesenchymal cell proliferation involved in lung development vasculogenesis involved in coronary vascular morphogenesis somite development positive regulation of sclerotome development fungiform papilla development fungiform papilla morphogenesis fungiform papilla formation positive regulation of oligodendrocyte progenitor proliferation cellular response to lithium ion dopaminergic neuron differentiation commissural neuron axon guidance renal system development metanephric mesenchymal cell proliferation involved in metanephros development negative regulation of canonical Wnt signaling pathway negative regulation of cholesterol efflux apoptotic signaling pathway regulation of protein localization to nucleus negative regulation of neuron death positive regulation of sprouting angiogenesis negative regulation of dopaminergic neuron differentiation tracheoesophageal septum formation negative regulation of ureter smooth muscle cell differentiation positive regulation of ureter smooth muscle cell differentiation negative regulation of kidney smooth muscle cell differentiation positive regulation of kidney smooth muscle cell differentiation positive regulation of mesenchymal cell proliferation involved in ureter development positive regulation of endothelial cell chemotaxis negative regulation of mesenchymal cell apoptotic process hydrolase activity uc008wua.1 uc008wua.2 uc008wua.3 uc008wua.4 
ENSMUST00000002710.10 Pdcd2l ENSMUST00000002710.10 programmed cell death 2-like, transcript variant 1 (from RefSeq NM_026549.4) ENSMUST00000002710.1 ENSMUST00000002710.2 ENSMUST00000002710.3 ENSMUST00000002710.4 ENSMUST00000002710.5 ENSMUST00000002710.6 ENSMUST00000002710.7 ENSMUST00000002710.8 ENSMUST00000002710.9 NM_026549 PDD2L_MOUSE Q8C5N5 Q8R185 Q9D1M3 uc009giw.1 uc009giw.2 uc009giw.3 Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase. molecular_function cytoplasm cell cycle biological_process uc009giw.1 uc009giw.2 uc009giw.3 
ENSMUST00000002733.7 Gtf2f1 ENSMUST00000002733.7 general transcription factor IIF, polypeptide 1, transcript variant 19 (from RefSeq NR_185085.1) ENSMUST00000002733.1 ENSMUST00000002733.2 ENSMUST00000002733.3 ENSMUST00000002733.4 ENSMUST00000002733.5 ENSMUST00000002733.6 NR_185085 Q3THK3 Q8R5B7 T2FA_MOUSE uc008ddp.1 uc008ddp.2 uc008ddp.3 TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity). Heterodimer of an alpha and a beta subunit. Interacts with GTF2F2, CTDP1, TAF6/TAFII80 and URI1 (By similarity). Interacts with GTF2B (via C-terminus and preferentially via acetylated form); this interaction prevents binding of GTF2B to GTF2F2 (By similarity). Nucleus Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases. Belongs to the TFIIF alpha subunit family. DNA binding protein binding nucleus transcription factor TFIID complex transcription initiation from RNA polymerase II promoter transcription factor binding response to virus obsolete general RNA polymerase II transcription factor activity phosphatase activator activity protein phosphatase binding protein domain specific binding cell junction negative regulation of protein binding positive regulation of transcription elongation from RNA polymerase II promoter macromolecular complex positive regulation of catalytic activity intracellular membrane-bounded organelle positive regulation of transcription from RNA polymerase II promoter promoter-specific chromatin binding uc008ddp.1 uc008ddp.2 uc008ddp.3 
ENSMUST00000002735.9 Clpp ENSMUST00000002735.9 caseinolytic mitochondrial matrix peptidase proteolytic subunit (from RefSeq NM_017393.2) CLPP_MOUSE ENSMUST00000002735.1 ENSMUST00000002735.2 ENSMUST00000002735.3 ENSMUST00000002735.4 ENSMUST00000002735.5 ENSMUST00000002735.6 ENSMUST00000002735.7 ENSMUST00000002735.8 NM_017393 O88696 Q3TI13 uc008ddm.1 uc008ddm.2 uc008ddm.3 uc008ddm.4 Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion. Reaction=Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr- Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).; EC=3.4.21.92; Evidence=; Fourteen CLPP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity. Component of the Clp complex formed by the assembly of two CLPP heptameric rings with two CLPX hexameric rings, giving rise to a symmetrical structure with two central CLPP rings flanked by a CLPX ring at either end of the complex. Mitochondrion matrix Detected in liver (at protein level). High levels found in heart, liver and skeletal muscle. Homozygous pups are born at about 60 % of the expected Mendelian rate, indicating decreased intrauterine survival. Mutant mice are smaller in size than wild-type littermates, show decreased motor activity, are completely deaf after 12 months and their lifespan is decreased relative to that of wild-type littermates. Both female and male mutant mice are completely infertile due to defects in germ cell development. Belongs to the peptidase S14 family. ATP-dependent peptidase activity serine-type endopeptidase activity protein binding mitochondrion mitochondrial matrix proteolysis misfolded or incompletely synthesized protein catabolic process peptidase activity serine-type peptidase activity endopeptidase Clp complex hydrolase activity identical protein binding ATPase binding protein homooligomerization proteolysis involved in cellular protein catabolic process uc008ddm.1 uc008ddm.2 uc008ddm.3 uc008ddm.4 
ENSMUST00000002737.7 Alkbh7 ENSMUST00000002737.7 alkB homolog 7, transcript variant 1 (from RefSeq NM_025538.3) ALKB7_MOUSE ENSMUST00000002737.1 ENSMUST00000002737.2 ENSMUST00000002737.3 ENSMUST00000002737.4 ENSMUST00000002737.5 ENSMUST00000002737.6 NM_025538 Q8K1H3 Q9CY41 Q9D6Z0 Q9D942 Spata11 uc008ddn.1 uc008ddn.2 uc008ddn.3 uc008ddn.4 uc008ddn.5 May function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity (By similarity). Involved in fatty acid metabolism. Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D6Z0-1; Sequence=Displayed; Name=2; IsoId=Q9D6Z0-2; Sequence=VSP_019132; Widely expressed. Increased body weight and body fat, a phenotype amplified under high-fat diet. Belongs to the alkB family. Sequence=AAH29677.1; Type=Erroneous initiation; Evidence=; mitochondrion mitochondrial matrix fatty acid metabolic process cellular response to DNA damage stimulus regulation of lipid storage programmed cell death oxidoreductase activity metal ion binding dioxygenase activity oxidation-reduction process regulation of mitochondrial membrane permeability involved in programmed necrotic cell death oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors uc008ddn.1 uc008ddn.2 uc008ddn.3 uc008ddn.4 uc008ddn.5 
ENSMUST00000002740.3 Pspn ENSMUST00000002740.3 persephin (from RefSeq NM_008954.4) A1L3Q1 A1L3Q1_MOUSE ENSMUST00000002740.1 ENSMUST00000002740.2 NM_008954 Pspn uc008ddo.1 uc008ddo.2 uc008ddo.3 This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Mice lacking a functional copy of this gene exhibit hypersensitivity to cerebral ischemia. [provided by RefSeq, Aug 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.440535.1, BC130229.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Secreted Belongs to the TGF-beta family. GDNF subfamily. extracellular region signal transduction growth factor activity uc008ddo.1 uc008ddo.2 uc008ddo.3 
ENSMUST00000002757.11 Cox16 ENSMUST00000002757.11 cytochrome c oxidase assembly protein 16, transcript variant 1 (from RefSeq NM_025461.6) COX16_MOUSE Cox16 ENSMUST00000002757.1 ENSMUST00000002757.10 ENSMUST00000002757.2 ENSMUST00000002757.3 ENSMUST00000002757.4 ENSMUST00000002757.5 ENSMUST00000002757.6 ENSMUST00000002757.7 ENSMUST00000002757.8 ENSMUST00000002757.9 NM_025461 Q8BNX4 Q99J15 Q9CR63 uc007oce.1 uc007oce.2 uc007oce.3 uc007oce.4 Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6. Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines. Associates with the MITRAC complex. Interacts with MT-CO2/COX; specifically interacts with newly synthesized MT-CO2/COX. Interacts with SCO1, SCO2 and COA6. Mitochondrion inner membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CR63-1; Sequence=Displayed; Name=2; IsoId=Q9CR63-2; Sequence=VSP_014603; Belongs to the COX16 family. molecular_function mitochondrion mitochondrial inner membrane membrane integral component of membrane integral component of mitochondrial inner membrane mitochondrial membrane mitochondrial respiratory chain complex IV assembly uc007oce.1 uc007oce.2 uc007oce.3 uc007oce.4 
ENSMUST00000002765.9 Prkd1 ENSMUST00000002765.9 protein kinase D1, transcript variant 5 (from RefSeq NR_168537.1) E9QNA3 ENSMUST00000002765.1 ENSMUST00000002765.2 ENSMUST00000002765.3 ENSMUST00000002765.4 ENSMUST00000002765.5 ENSMUST00000002765.6 ENSMUST00000002765.7 ENSMUST00000002765.8 KPCD1_MOUSE NR_168537 Pkcm Pkd Prkcm Q62101 uc007nmj.1 uc007nmj.2 uc007nmj.3 uc007nmj.4 Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:12407104, PubMed:14963034, PubMed:15192707, PubMed:20463010, PubMed:24161911, PubMed:28716882). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS) (PubMed:11784866). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane (PubMed:11239398). May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-469 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion (PubMed:15192707). In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:19029091). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway (PubMed:14963034, PubMed:20463010). Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:24161911). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1- HDAC5 pathway is also involved in angiogenesis by mediating VEGFA- induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:28716882). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (By similarity). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (PubMed:27184844). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Activated by DAG and phorbol esters. Phorbol- ester/DAG-type domain 1 binds DAG with high affinity and appears to play the dominant role in mediating translocation to the cell membrane and trans-Golgi network. Phorbol-ester/DAG-type domain 2 binds phorbol ester with higher affinity. Autophosphorylation of Ser-748 and phosphorylation of Ser-744 by PKC relieves auto-inhibition by the PH domain. Phosphorylation on Tyr-469 by the SRC-ABL1 pathway in response to oxidative stress, is also required for activation. Activated by DAPK1 under oxidative stress (By similarity). Interacts (via N-terminus) with ADAP1/CENTA1. Interacts with MAPK13. Interacts with DAPK1 in an oxidative stress-regulated manner. Interacts with USP28; the interaction induces phosphorylation of USP28 and activated KRAS-mediated stabilization of ZNF304 (By similarity). Interacts with AKAP13 (via C-terminal domain) (PubMed:24161911). Q62101; P05106: ITGB3; Xeno; NbExp=2; IntAct=EBI-6903636, EBI-702847; Cytoplasm Cell membrane Golgi apparatus, trans-Golgi network Note=Translocation to the cell membrane is required for kinase activation. Phosphorylated at Ser-403 and Ser-407 by MAPK13 during regulation of insulin secretion in pancreatic beta cells (By similarity). Phosphorylated by DAPK1 (By similarity). Phosphorylated at Tyr-93 and by ABL at Tyr-469, which primes the kinase in response to oxidative stress, and promotes a second step activating phosphorylation at Ser- 744/Ser-748 by PKRD (By similarity). Phosphorylated at Ser-916 upon S.enterica infection in macrophages (PubMed:27184844). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. nucleotide binding autophagosome membrane angiogenesis positive regulation of endothelial cell proliferation immune system process protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding nucleus cytoplasm Golgi apparatus trans-Golgi network cytosol plasma membrane cell-cell junction cell cortex protein phosphorylation apoptotic process inflammatory response Golgi organization Ras protein signal transduction nervous system development positive regulation of autophagy positive regulation of endothelial cell migration regulation of keratinocyte proliferation positive regulation of neuron projection development membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cell differentiation regulation of protein stability positive regulation of CREB transcription factor activity positive regulation of peptidyl-serine phosphorylation cellular response to amino acid starvation cellular response to oxidative stress intracellular signal transduction cellular response to vascular endothelial growth factor stimulus positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway positive regulation of protein import into nucleus identical protein binding positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of blood vessel endothelial cell migration innate immune response positive regulation of osteoblast differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation metal ion binding vascular endothelial growth factor receptor signaling pathway Golgi vesicle transport defense response to Gram-negative bacterium positive regulation of NF-kappaB transcription factor activity regulation of release of sequestered calcium ion into cytosol negative regulation of cell death cellular response to hydroperoxide protein kinase D signaling positive regulation of histone deacetylase activity positive regulation of endothelial cell chemotaxis uc007nmj.1 uc007nmj.2 uc007nmj.3 uc007nmj.4 
ENSMUST00000002790.14 Cse1l ENSMUST00000002790.14 chromosome segregation 1 like (from RefSeq NM_023565.3) ENSMUST00000002790.1 ENSMUST00000002790.10 ENSMUST00000002790.11 ENSMUST00000002790.12 ENSMUST00000002790.13 ENSMUST00000002790.2 ENSMUST00000002790.3 ENSMUST00000002790.4 ENSMUST00000002790.5 ENSMUST00000002790.6 ENSMUST00000002790.7 ENSMUST00000002790.8 ENSMUST00000002790.9 NM_023565 Q9ERK4 XPO2_MOUSE Xpo2 uc008nys.1 uc008nys.2 uc008nys.3 uc008nys.4 Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in the presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1. Interacts with CFTR. Cytoplasm Nucleus Note=Shuttles between the nucleus and the cytoplasm. Ubiquitous. Detected in embryos from 5 to 17 dpc. Highly expressed in adult testis, heart, brain, lung, liver, skeletal muscle, spleen and kidney. Complete embryonic lethality at around 5.5 dpc. Belongs to the XPO2/CSE1 family. nuclear export signal receptor activity protein binding nucleus nuclear envelope nucleoplasm cytoplasm cytosol protein import into nucleus protein export from nucleus intracellular protein transport Ran GTPase binding protein transport uc008nys.1 uc008nys.2 uc008nys.3 uc008nys.4 
ENSMUST00000002808.7 Prkra ENSMUST00000002808.7 protein kinase, interferon inducible double stranded RNA dependent activator, transcript variant 13 (from RefSeq NR_185271.1) ENSMUST00000002808.1 ENSMUST00000002808.2 ENSMUST00000002808.3 ENSMUST00000002808.4 ENSMUST00000002808.5 ENSMUST00000002808.6 NR_185271 PRKRA_MOUSE Q9CZB7 Q9WTX2 Rax uc008kff.1 uc008kff.2 uc008kff.3 Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1 (By similarity). Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Promotes UBC9- p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner. Homodimer. Interacts with DICER1, AGO2 and TARBP2. Also able to interact with dsRNA (By similarity). Interacts with EIF2AK2/PKR through its DRBM domains. Interacts with DUS2L (via DRBM domain) (By similarity). Interacts with UBC9. Forms a complex with UBC9 and p53/TP53. Cytoplasm, perinuclear region Cytoplasm Expressed in brain, heart, kidney, liver, lung, muscle, spleen and testis. Self-association may occur via interactions between DRBM domains as follows: DRBM 1/DRBM 1, DRBM 1/DRBM 2, DRBM 2/DRBM 2 or DRBM 3/DRBM3. Phosphorylated at Ser-246 in unstressed cells and at Ser-287 in stressed cells. Phosphorylation at Ser-246 appears to be a prerequisite for subsequent phosphorylation at Ser-287. Phosphorylation at Ser-246 and Ser-287 are necessary for activation of EIF2AK2/PKR under conditions of stress (By similarity). Belongs to the PRKRA family. RNA binding double-stranded RNA binding protein binding nucleoplasm cytoplasm cytosol protein phosphorylation enzyme activator activity positive regulation of cell proliferation enzyme binding protein kinase binding production of siRNA involved in RNA interference gene silencing by RNA pre-miRNA processing cellular response to oxidative stress production of miRNAs involved in gene silencing by miRNA outer ear morphogenesis middle ear morphogenesis identical protein binding protein homodimerization activity positive regulation of catalytic activity ear development perinuclear region of cytoplasm skeletal system morphogenesis protein stabilization RISC-loading complex pre-miRNA binding positive regulation of intrinsic apoptotic signaling pathway uc008kff.1 uc008kff.2 uc008kff.3 
ENSMUST00000002809.14 Fkbp7 ENSMUST00000002809.14 FK506 binding protein 7, transcript variant 1 (from RefSeq NM_010222.2) ENSMUST00000002809.1 ENSMUST00000002809.10 ENSMUST00000002809.11 ENSMUST00000002809.12 ENSMUST00000002809.13 ENSMUST00000002809.2 ENSMUST00000002809.3 ENSMUST00000002809.4 ENSMUST00000002809.5 ENSMUST00000002809.6 ENSMUST00000002809.7 ENSMUST00000002809.8 ENSMUST00000002809.9 Fkbp7 NM_010222 Q3UU11 Q3UU11_MOUSE uc008kfh.1 uc008kfh.2 uc008kfh.3 uc008kfh.4 Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence= protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity calcium ion binding isomerase activity uc008kfh.1 uc008kfh.2 uc008kfh.3 uc008kfh.4 
ENSMUST00000002818.9 Ykt6 ENSMUST00000002818.9 YKT6 v-SNARE homolog (S. cerevisiae) (from RefSeq NM_019661.5) ENSMUST00000002818.1 ENSMUST00000002818.2 ENSMUST00000002818.3 ENSMUST00000002818.4 ENSMUST00000002818.5 ENSMUST00000002818.6 ENSMUST00000002818.7 ENSMUST00000002818.8 NM_019661 O88595 Q9CQW1 YKT6_MOUSE uc007hxp.1 uc007hxp.2 uc007hxp.3 uc007hxp.4 uc007hxp.5 uc007hxp.6 Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L, GOSR1 and STX5. Cytoplasm, cytosol Cytoplasmic vesicle membrane ; Lipid-anchor ; Cytoplasmic side Golgi apparatus membrane ; Lipid- anchor ; Cytoplasmic side Note=Probably cycles through vesicles between Golgi and endosomes. The longin domain regulates palmitoylation and membrane targeting. Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting. Farnesylation is required for Golgi targeting. Belongs to the synaptobrevin family. Golgi membrane SNAP receptor activity cytoplasm mitochondrion endosome endoplasmic reticulum Golgi apparatus cytosol integral component of plasma membrane ER to Golgi vesicle-mediated transport vesicle targeting vesicle docking involved in exocytosis protein transport membrane integral component of membrane vesicle-mediated transport transferase activity protein-cysteine S-palmitoyltransferase activity cytoplasmic vesicle membrane SNARE complex cytoplasmic vesicle retrograde transport, endosome to Golgi neuronal cell body membrane fusion apical dendrite basilar dendrite uc007hxp.1 uc007hxp.2 uc007hxp.3 uc007hxp.4 uc007hxp.5 uc007hxp.6 
ENSMUST00000002825.6 Baz1b ENSMUST00000002825.6 bromodomain adjacent to zinc finger domain, 1B (from RefSeq NM_011714.2) B9EJ99 BAZ1B_MOUSE ENSMUST00000002825.1 ENSMUST00000002825.2 ENSMUST00000002825.3 ENSMUST00000002825.4 ENSMUST00000002825.5 NM_011714 Q3URP5 Q3USR7 Q3UVM2 Q8CAU9 Q9CU68 Q9Z277 Wbscr9 Wstf uc008zxz.1 uc008zxz.2 uc008zxz.3 uc008zxz.4 Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (By similarity). Involved in DNA damage response by phosphorylating 'Tyr- 142' of histone H2AX (H2AXY142ph) (PubMed:19092802). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA- templated processes such as DNA replication, transcription, and repair (PubMed:11980720). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:16514417). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (By similarity). The WICH-5 ISWI chromatin remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (PubMed:16514417). Within the B-WICH complex has a role in RNA polymerase III transcription (By similarity). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Component of the WICH-1 ISWI chromatin remodeling complex, at least composed of SMARCA1 and BAZ1B/WSTF, which regulates the spacing of histone octamers on the DNA template to facilitate access to DNA (By similarity). Within the WICH-1 ISWI chromatin remodeling complex interacts with SMARCA1; the interaction is direct (By similarity). Component of the WICH-5 ISWI chromatin remodeling complex (also called the WICH complex), at least composed of SMARCA5/SNF2H and BAZ1B/WSTF, which regulates the spacing of histone octamers on the DNA template to facilitate access to DNA (PubMed:16514417). Within the WICH-5 ISWI chromatin remodeling complex interacts with SMARCA5/SNF2H; the interaction is direct (PubMed:16514417, PubMed:19092802). Component of the B-WICH chromatin remodeling complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (By similarity). Within the B-WICH chromatin remodeling complex, interacts with SMARCA5/SNF2H, DDX21, DEK, MYBBP1A, SF3B1 and ERCC6 (By similarity). Interacts with MYO1C (PubMed:16514417). Interacts with PCNA; the interaction is direct and is required for BAZ1B/WSTF binding to replication foci during S phase (By similarity). Interacts with CDT1 (By similarity). Q9Z277; Q91ZW3: Smarca5; NbExp=2; IntAct=EBI-927576, EBI-927547; Nucleus te=Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA (By similarity). Localizes to sites of DNA damage (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z277-1; Sequence=Displayed; Name=2; IsoId=Q9Z277-2; Sequence=VSP_037470; Expressed as early as day 7 and in equal amounts during gestation. Belongs to the WAL family. BAZ1B subfamily. nucleotide binding condensed chromosome protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding nucleus pericentric heterochromatin chromatin assembly or disassembly chromatin remodeling cellular response to DNA damage stimulus kinase activity phosphorylation histone phosphorylation nuclear body transferase activity peptidyl-tyrosine phosphorylation histone kinase activity histone binding nuclear replication fork metal ion binding uc008zxz.1 uc008zxz.2 uc008zxz.3 uc008zxz.4 
ENSMUST00000002837.11 Tmed5 ENSMUST00000002837.11 transmembrane p24 trafficking protein 5, transcript variant 1 (from RefSeq NM_028876.3) ENSMUST00000002837.1 ENSMUST00000002837.10 ENSMUST00000002837.2 ENSMUST00000002837.3 ENSMUST00000002837.4 ENSMUST00000002837.5 ENSMUST00000002837.6 ENSMUST00000002837.7 ENSMUST00000002837.8 ENSMUST00000002837.9 NM_028876 Q3TDS6 Q9CXE7 TMED5_MOUSE uc008ynp.1 uc008ynp.2 uc008ynp.3 Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity). Interacts with TMED9 and TMED10. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Golgi apparatus, cis-Golgi network membrane ; Single-pass type I membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein Note=Probably cycles between compartments of the early secretatory pathway. Belongs to the EMP24/GP25L family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cis-Golgi network intracellular protein transport ER to Golgi vesicle-mediated transport Golgi organization protein transport membrane integral component of membrane ER to Golgi transport vesicle endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum exit site Golgi ribbon formation uc008ynp.1 uc008ynp.2 uc008ynp.3 
ENSMUST00000002839.9 Ppp2r5d ENSMUST00000002839.9 protein phosphatase 2, regulatory subunit B', delta, transcript variant 1 (from RefSeq NM_009358.3) ENSMUST00000002839.1 ENSMUST00000002839.2 ENSMUST00000002839.3 ENSMUST00000002839.4 ENSMUST00000002839.5 ENSMUST00000002839.6 ENSMUST00000002839.7 ENSMUST00000002839.8 NM_009358 Ppp2r5d Q91V89 Q91V89_MOUSE uc008cua.1 uc008cua.2 uc008cua.3 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Belongs to the phosphatase 2A regulatory subunit B56 family. protein phosphatase type 2A complex regulation of protein phosphorylation phosphoprotein phosphatase activity protein binding nucleus cytosol protein dephosphorylation signal transduction negative regulation of peptidyl-threonine phosphorylation positive regulation of neuron projection development protein phosphatase regulator activity regulation of protein autophosphorylation positive regulation of protein dephosphorylation regulation of phosphoprotein phosphatase activity positive regulation of transcription from RNA polymerase II promoter positive regulation of neurotrophin TRK receptor signaling pathway cellular response to growth factor stimulus protein phosphatase activator activity uc008cua.1 uc008cua.2 uc008cua.3 
ENSMUST00000002840.9 Pex6 ENSMUST00000002840.9 peroxisomal biogenesis factor 6, transcript variant 1 (from RefSeq NM_145488.2) ENSMUST00000002840.1 ENSMUST00000002840.2 ENSMUST00000002840.3 ENSMUST00000002840.4 ENSMUST00000002840.5 ENSMUST00000002840.6 ENSMUST00000002840.7 ENSMUST00000002840.8 NM_145488 PEX6_MOUSE Pex6 Q6YNQ9 Q99LC9 uc008cud.1 uc008cud.2 Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers. Interacts with PEX26; interaction is direct and promotes recruitment to peroxisomal membranes. Interacts with ZFAND6. Cytoplasm, cytosol Peroxisome membrane Cell projection, cilium, photoreceptor outer segment Note=Associated with peroxisomal membranes; anchored by PEX26 to peroxisome membranes (By similarity). Localized at the base of the outer segment of photoreceptor cells (PubMed:26593283). In the teeth, expressed in ameloblasts and odontoblasts (PubMed:26593283). Expressed in the retina, at higher levels in the ganglion cell layer and photoreceptor layer at the joint between the outer and inner segments (PubMed:26593283, PubMed:27302843). Belongs to the AAA ATPase family. nucleotide binding photoreceptor outer segment protein binding ATP binding cytoplasm peroxisome peroxisomal membrane cytosol protein targeting to peroxisome peroxisome organization protein C-terminus binding membrane protein import into peroxisome matrix protein import into peroxisome matrix, translocation ATPase activity ATPase activity, coupled cell projection macromolecular complex binding protein stabilization photoreceptor cell cilium uc008cud.1 uc008cud.2 
ENSMUST00000002844.14 Mrpl2 ENSMUST00000002844.14 mitochondrial ribosomal protein L2, transcript variant 1 (from RefSeq NM_025302.4) ENSMUST00000002844.1 ENSMUST00000002844.10 ENSMUST00000002844.11 ENSMUST00000002844.12 ENSMUST00000002844.13 ENSMUST00000002844.2 ENSMUST00000002844.3 ENSMUST00000002844.4 ENSMUST00000002844.5 ENSMUST00000002844.6 ENSMUST00000002844.7 ENSMUST00000002844.8 ENSMUST00000002844.9 NM_025302 Q9D773 RM02_MOUSE uc008ctm.1 uc008ctm.2 uc008ctm.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uL2 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation mitochondrial translation uc008ctm.1 uc008ctm.2 uc008ctm.3 
ENSMUST00000002846.9 Gnmt ENSMUST00000002846.9 glycine N-methyltransferase, transcript variant 4 (from RefSeq NR_182115.1) ENSMUST00000002846.1 ENSMUST00000002846.2 ENSMUST00000002846.3 ENSMUST00000002846.4 ENSMUST00000002846.5 ENSMUST00000002846.6 ENSMUST00000002846.7 ENSMUST00000002846.8 GNMT_MOUSE NR_182115 Q91WN7 Q9QXF8 uc008cue.1 uc008cue.2 uc008cue.3 Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate (PubMed:15340920). Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L- methionine and S-adenosyl-L-homocysteine (PubMed:16779654). Reaction=glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L- homocysteine + sarcosine; Xref=Rhea:RHEA:19937, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305, ChEBI:CHEBI:57433, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.20; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19938; Evidence=; Inhibited by 5-methyltetrahydrofolate monoglutamate and by 5-methyltetrahydrofolate pentaglutamate, inhibition is much more effective by the pentaglutamate form than by the monoglutamate form. Two molecules of 5-methyltetrahydrofolate are bound per tetramer. The binding sites are localized between subunits. Inhibitor binding may preclude movements of the polypeptide chain that are necessary for enzyme activity. Kinetic parameters: KM=180 uM for S-adenosyl-L-methionine ; KM=3.6 mM for glycine ; Homotetramer. Cytoplasm Deficient mice are fertile and display elevated levels of methionine and S-adenosylmethionine in the liver. At 3 and 8 months of age, the livers at 3 and 8 months of age show evidence of fatty accumulation and fibrosis that worsen progressively. Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. folic acid binding cytoplasm cytosol glycogen metabolic process regulation of gluconeogenesis methionine metabolic process one-carbon metabolic process methyltransferase activity glycine binding transferase activity glycine N-methyltransferase activity methylation identical protein binding S-adenosylhomocysteine metabolic process S-adenosylmethionine metabolic process protein homotetramerization sarcosine metabolic process S-adenosyl-L-methionine binding uc008cue.1 uc008cue.2 uc008cue.3 
ENSMUST00000002850.8 Abcc6 ENSMUST00000002850.8 ATP-binding cassette, sub-family C member 6 (from RefSeq NM_018795.2) A2TAJ0 A2TAJ1 ENSMUST00000002850.1 ENSMUST00000002850.2 ENSMUST00000002850.3 ENSMUST00000002850.4 ENSMUST00000002850.5 ENSMUST00000002850.6 ENSMUST00000002850.7 F8VPT2 MRP6_MOUSE Mrp6 NM_018795 Q80YB6 Q9R1S7 uc009gya.1 uc009gya.2 uc009gya.3 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein is unknown; however, a similar rat protein has been identified as the major canalicular bile salt export pump of liver. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF109740.1, BC040400.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM- GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity). Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. Reaction=an S-substituted glutathione(in) + ATP + H2O = ADP + an S- substituted glutathione(out) + H(+) + phosphate; Xref=Rhea:RHEA:19121, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:90779, ChEBI:CHEBI:456216; EC=7.6.2.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19122; Evidence=; Reaction=ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate; Xref=Rhea:RHEA:38963, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57973, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38964; Evidence=; Basolateral cell membrane ; Multi-pass membrane protein Basal cell membrane ; Multi-pass membrane protein Glycosylated. Deficient mice spontaneously develop calcification and elastic fiber abnormalities in blood vessels and Bruch's membrane in the eye, whereas no clear changes were seen in the extracellular matrix of the skin. Calcification of blood vessels is most prominent in small arteries in the cortex of the kidney, but in old mice, it occurrs also in other organs and in the aorta and vena cava (PubMed:15888484). Mice have reduced inorganic pyrophosphate (PPi) plasma levels, a strong inhibitor of mineralization (PubMed:24277820). Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. nucleotide binding ATP binding nucleus plasma membrane membrane integral component of membrane basolateral plasma membrane apical plasma membrane lateral plasma membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances transmembrane transport uc009gya.1 uc009gya.2 uc009gya.3 
ENSMUST00000002855.14 Kdelr1 ENSMUST00000002855.14 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 (from RefSeq NM_133950.2) ENSMUST00000002855.1 ENSMUST00000002855.10 ENSMUST00000002855.11 ENSMUST00000002855.12 ENSMUST00000002855.13 ENSMUST00000002855.2 ENSMUST00000002855.3 ENSMUST00000002855.4 ENSMUST00000002855.5 ENSMUST00000002855.6 ENSMUST00000002855.7 ENSMUST00000002855.8 ENSMUST00000002855.9 ERD21_MOUSE NM_133950 Q99JH8 uc009gxn.1 uc009gxn.2 uc009gxn.3 Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. Upon ligand binding the receptor oligomerizes and interacts with components of the transport machinery such as ARFGAP1 and ARF1. Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasmic vesicle, COPI-coated vesicle membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. Phosphorylation by PKA at Ser-209 is required for endoplasmic reticulum retention function. Belongs to the ERD2 family. Golgi membrane T cell cytokine production KDEL sequence binding endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cis-Golgi network protein retention in ER lumen ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER protein transport membrane integral component of membrane vesicle-mediated transport T cell differentiation COPI-coated vesicle membrane cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment membrane ER retention sequence binding T cell apoptotic process uc009gxn.1 uc009gxn.2 uc009gxn.3 
ENSMUST00000002880.7 Btbd6 ENSMUST00000002880.7 BTB domain containing 6, transcript variant 1 (from RefSeq NM_201646.2) BTBD6_MOUSE ENSMUST00000002880.1 ENSMUST00000002880.2 ENSMUST00000002880.3 ENSMUST00000002880.4 ENSMUST00000002880.5 ENSMUST00000002880.6 NM_201646 Q3UIB3 Q8K2J9 uc288jpp.1 uc288jpp.2 Adapter protein for the cul3 E3 ubiquitin-protein ligase complex (By similarity). Involved in late neuronal development and muscle formation (By similarity). Cytoplasm Note=Found in punctated bodies in the cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2J9-2; Sequence=Displayed; Name=2; IsoId=Q8K2J9-1; Sequence=VSP_061437; Sequence=AAH31195.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cytoplasm cytosol neurogenesis uc288jpp.1 uc288jpp.2 
ENSMUST00000002883.7 Sfrp4 ENSMUST00000002883.7 secreted frizzled-related protein 4 (from RefSeq NM_016687.3) ENSMUST00000002883.1 ENSMUST00000002883.2 ENSMUST00000002883.3 ENSMUST00000002883.4 ENSMUST00000002883.5 ENSMUST00000002883.6 NM_016687 Q91ZX9 Q9Z1N6 SFRP4_MOUSE uc007ppg.1 uc007ppg.2 uc007ppg.3 uc007ppg.4 uc007ppg.5 Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (PubMed:27355534). SFRP4 plays a role in bone morphogenesis (PubMed:27355534). May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity). Secreted Expressed in the ovary. Localized to granulosa cells of periovulatory follicles and corpora lutea. Weakly expressed in adult tissues including kidney, brain and lung. Only weakly expressed in developing embryo except for developing teeth, eye and salivary gland. In the developing eye, from 12.5 dpc, expressed in the future neural retina, in both the inner and outer cell layers. In the developing teeth, strong expression detected in the developing incisor teeth at 14.5 dpc. Expression localized to the mesenchyme of the dental follicle surrounding the enamel organ only at the early cap stage. Highly expressed in the branching epithelium of the salivary gland. Induced in ovaries by chorionic gonadotropin (CG). The FZ domain is involved in binding with Wnt ligands. Mice laking Sfrp4 have increased trabecular bone, reduced cortical-bone thickness, and failure of bone modeling during growth, resulting in wider bones with thinner and mechanically inadequate cortexes. Belongs to the secreted frizzled-related protein (sFRP) family. positive regulation of receptor internalization extracellular region extracellular space nucleus cytoplasm multicellular organism development negative regulation of cell proliferation cell surface positive regulation of gene expression Wnt signaling pathway Wnt-protein binding cell differentiation regulation of BMP signaling pathway non-canonical Wnt signaling pathway positive regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of epidermal cell differentiation negative regulation of JNK cascade phosphate ion homeostasis canonical Wnt signaling pathway bone morphogenesis negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of keratinocyte apoptotic process negative regulation of non-canonical Wnt signaling pathway negative regulation of sodium-dependent phosphate transport uc007ppg.1 uc007ppg.2 uc007ppg.3 uc007ppg.4 uc007ppg.5 
ENSMUST00000002885.8 Epdr1 ENSMUST00000002885.8 ependymin related 1 (from RefSeq NM_134065.4) ENSMUST00000002885.1 ENSMUST00000002885.2 ENSMUST00000002885.3 ENSMUST00000002885.4 ENSMUST00000002885.5 ENSMUST00000002885.6 ENSMUST00000002885.7 EPDR1_MOUSE Epdr2 Merp1 Merp2 NM_134065 Q06BK9 Q8BQY1 Q8CAI2 Q99M71 uc007ppe.1 uc007ppe.2 uc007ppe.3 uc007ppe.4 Binds anionic lipids and gangliosides at acidic pH. Homodimer. Lysosome lumen Secreted Note=Lysosomal and also secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99M71-1; Sequence=Displayed; Name=2; IsoId=Q99M71-2; Sequence=VSP_031977; Detected in brain, small intestine and in soleus, extensor digitorum longus and white gastrocnemius (at protein level) (PubMed:16954209). Detected in brain and skeletal muscle, and at lower leavels in heart (PubMed:11749721). N-glycosylated; the glycan contains mannose-6-phosphate moieties. Belongs to the ependymin family. molecular_function calcium ion binding extracellular region extracellular space lysosome cell-matrix adhesion biological_process lipid binding lysosomal lumen uc007ppe.1 uc007ppe.2 uc007ppe.3 uc007ppe.4 
ENSMUST00000002889.5 Flii ENSMUST00000002889.5 flightless I actin binding protein, transcript variant 1 (from RefSeq NM_022009.2) ENSMUST00000002889.1 ENSMUST00000002889.2 ENSMUST00000002889.3 ENSMUST00000002889.4 FLII_MOUSE Fli1 Fliih NM_022009 Q8K095 Q8VI44 Q9JJ28 uc007jgh.1 uc007jgh.2 uc007jgh.3 uc007jgh.4 This gene encodes a protein with gelsolin-like repeats and an N-terminal leucine-rich repeat domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. This protein may act as an actin-remodelling protein as well as a transcriptional coactivator. Homozygous knockout mice show embryonic lethality. This protein may act to regulate wound repair. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling (By similarity). Essential for early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. Interacts with actin, ACTL6A, NCOA2 and MYD88 (By similarity). Interacts with LRRFIP1 and LRRFIP2. Upon LPS stimulation, LRRFIP2 competes for MYD88-binding. LRRFIP1 constitutively blocks the interaction with MyD88, even in the absence of LPS (By similarity). Interacts with the nuclear receptors ESR1 and THRB (By similarity). Interacts with CARM1. Interacts with SGK3. Q9JJ28; Q6PHZ2: Camk2d; NbExp=5; IntAct=EBI-7996161, EBI-2308458; Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, focal adhesion. Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes. Expressed in blastocyst. Up-regulated in response to wounding. Increases the percentage of focal complex positive cells. Flii deficiency causes lethality during early embryogenesis at a stage preceding gastrulation. Sequence=AAH32282.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; actin binding protein binding nucleus nucleoplasm cytoplasm microtubule organizing center cytosol cytoskeleton brush border focal adhesion multicellular organism development actin cytoskeleton organization cell junction actin filament severing actin filament binding uc007jgh.1 uc007jgh.2 uc007jgh.3 uc007jgh.4 
ENSMUST00000002891.11 Top3a ENSMUST00000002891.11 topoisomerase (DNA) III alpha (from RefSeq NM_009410.4) ENSMUST00000002891.1 ENSMUST00000002891.10 ENSMUST00000002891.2 ENSMUST00000002891.3 ENSMUST00000002891.4 ENSMUST00000002891.5 ENSMUST00000002891.6 ENSMUST00000002891.7 ENSMUST00000002891.8 ENSMUST00000002891.9 NM_009410 Q5NCT2 Q5NCT2_MOUSE Top3a uc007jgl.1 uc007jgl.2 uc007jgl.3 Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Reaction=ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.; EC=5.6.2.1; Evidence= Belongs to the type IA topoisomerase family. DNA binding single-stranded DNA binding DNA topoisomerase activity DNA topoisomerase type I activity chromosome mitochondrion DNA topological change zinc ion binding PML body isomerase activity mitochondrial DNA metabolic process chromosome separation uc007jgl.1 uc007jgl.2 uc007jgl.3 
ENSMUST00000002902.8 Qtrt1 ENSMUST00000002902.8 queuine tRNA-ribosyltransferase catalytic subunit 1 (from RefSeq NM_021888.2) ENSMUST00000002902.1 ENSMUST00000002902.2 ENSMUST00000002902.3 ENSMUST00000002902.4 ENSMUST00000002902.5 ENSMUST00000002902.6 ENSMUST00000002902.7 NM_021888 Q80VS3 Q9JMA2 Qtrt1 TGT_MOUSE Tgt Tgut uc009oli.1 uc009oli.2 uc009oli.3 uc009oli.4 Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:19414587, PubMed:29862811). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity). Reaction=guanosine(34) in tRNA + queuine = guanine + queuosine(34) in tRNA; Xref=Rhea:RHEA:16633, Rhea:RHEA-COMP:10341, Rhea:RHEA- COMP:18571, ChEBI:CHEBI:16235, ChEBI:CHEBI:17433, ChEBI:CHEBI:74269, ChEBI:CHEBI:194431; EC=2.4.2.64; Evidence= Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2. Cytoplasm tochondrion outer membrane ; Peripheral membrane protein ytoplasmic side cleus Note=Weakly associates with mitochondria, possibly via QTRT2. Expressed in brain, heart, kidney, liver, ling, skeletal muscle, spleen and testis. Belongs to the queuine tRNA-ribosyltransferase family. Sequence=BAB27717.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB27717.1; Type=Frameshift; Evidence=; protein binding nucleus cytoplasm mitochondrion mitochondrial outer membrane tRNA modification tRNA processing queuine tRNA-ribosyltransferase activity membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups macromolecular complex protein homodimerization activity metal ion binding protein heterodimerization activity tRNA-guanine transglycosylation uc009oli.1 uc009oli.2 uc009oli.3 uc009oli.4 
ENSMUST00000002911.10 Hdgfl2 ENSMUST00000002911.10 HDGF like 2, transcript variant 5 (from RefSeq NM_001424790.1) D6CHX5 ENSMUST00000002911.1 ENSMUST00000002911.2 ENSMUST00000002911.3 ENSMUST00000002911.4 ENSMUST00000002911.5 ENSMUST00000002911.6 ENSMUST00000002911.7 ENSMUST00000002911.8 ENSMUST00000002911.9 HDGR2_MOUSE Hdgfrp2 NM_001424790 O35540 Q3UIH6 Q3UMU9 Q99L92 uc008dav.1 uc008dav.2 uc008dav.3 uc008dav.4 uc008dav.5 uc008dav.6 Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (By similarity). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (By similarity). Involved in cellular growth control, through the regulation of cyclin D1 expression (By similarity). Associates with chromatin (PubMed:22212508). [Isoform 1]: Binds to condensed chromatin in mitotic cells. [Isoform 3]: Binds to condensed chromatin in mitotic cells. [Isoform 4]: Binds to non-condensed chromatin in the presence of HDGF. Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3 (By similarity). Interacts with IWS1 (By similarity). Interacts with H2AX, POGZ, RBBP8 and CBX1 (By similarity). Interacts with histones H3K9me3, H3K27me3 and H3K36me2 (By similarity). Interacts with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Interacts with SMARCA4/BRG1/BAF190A, in a DPF3a-dependent manner (PubMed:32459350). Interacts with SMARCC1/BAF155 and SMARCD1/BAF60A in a DPF3a-dependent manner (By similarity). [Isoform 1]: Interacts with HDGF. [Isoform 3]: Interacts with HDGF. [Isoform 4]: Selectively interacts with HDGF (N-terminally processed form). Q3UMU9; P51859: Hdgf; NbExp=4; IntAct=EBI-7627961, EBI-2943087; Q3UMU9-1; P51859: Hdgf; NbExp=4; IntAct=EBI-7627862, EBI-2943087; Q3UMU9-3; P51859: Hdgf; NbExp=4; IntAct=EBI-7627932, EBI-2943087; Cytoplasm [Isoform 1]: Nucleus [Isoform 3]: Nucleus [Isoform 4]: Nucleus Note=Displays a punctate pattern and colocalizes with N-terminally processed HDFG. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Isoform a; IsoId=Q3UMU9-1; Sequence=Displayed; Name=2; IsoId=Q3UMU9-2; Sequence=VSP_031118, VSP_031119; Name=3; Synonyms=Isoform b; IsoId=Q3UMU9-3; Sequence=VSP_031117; Name=4; Synonyms=Isoform c; IsoId=Q3UMU9-4; Sequence=VSP_047648, VSP_031119; Ubiquitously expressed. Mice show severely impaired post-injury muscle regeneration. Belongs to the HDGF family. chromatin binding protein binding nucleus positive regulation of cell growth uc008dav.1 uc008dav.2 uc008dav.3 uc008dav.4 uc008dav.5 uc008dav.6 
ENSMUST00000002914.10 Chaf1a ENSMUST00000002914.10 chromatin assembly factor 1, subunit A (from RefSeq NM_013733.4) CAF1A_MOUSE Caip150 Chaf1a ENSMUST00000002914.1 ENSMUST00000002914.2 ENSMUST00000002914.3 ENSMUST00000002914.4 ENSMUST00000002914.5 ENSMUST00000002914.6 ENSMUST00000002914.7 ENSMUST00000002914.8 ENSMUST00000002914.9 NM_013733 Q3TU22 Q544M2 Q9QWF0 uc008das.1 uc008das.2 uc008das.3 Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. Homodimer. Part of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. CHAF1A binds directly to CHAF1B. Only minor amounts of RBBP4 are complexed with CHAF1A and CHAF1B in G1 phase. CHAF1A binds directly to PCNA and to CBX1. Interacts with MBD1. Interacts directly with CBX5 via the PxVxL motif. Interacts with CBX5. Interacts with histones H3.1, H3.2 and H3.1t (By similarity). Q9QWF0; P83917: Cbx1; NbExp=3; IntAct=EBI-639217, EBI-78119; Q9QWF0; P70338: Gfi1; NbExp=5; IntAct=EBI-639217, EBI-3954754; Nucleus Note=DNA replication foci. Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain. Belongs to the CHAF1A family. nuclear chromatin protein binding nucleus DNA replication DNA repair nucleosome assembly DNA replication-dependent nucleosome assembly cellular response to DNA damage stimulus cell cycle chromatin assembly macromolecular complex CAF-1 complex identical protein binding chromo shadow domain binding uc008das.1 uc008das.2 uc008das.3 
ENSMUST00000002923.10 Adprh ENSMUST00000002923.10 ADP-ribosylarginine hydrolase (from RefSeq NM_007414.3) Adprh ENSMUST00000002923.1 ENSMUST00000002923.2 ENSMUST00000002923.3 ENSMUST00000002923.4 ENSMUST00000002923.5 ENSMUST00000002923.6 ENSMUST00000002923.7 ENSMUST00000002923.8 ENSMUST00000002923.9 NM_007414 Q3U5N4 Q3U5N4_MOUSE uc007zex.1 uc007zex.2 uc007zex.3 Belongs to the ADP-ribosylglycohydrolase family. magnesium ion binding ADP-ribosylarginine hydrolase activity extracellular space cytosol cellular protein modification process hydrolase activity potassium ion binding protein de-ADP-ribosylation uc007zex.1 uc007zex.2 uc007zex.3 
ENSMUST00000002925.6 Timmdc1 ENSMUST00000002925.6 translocase of inner mitochondrial membrane domain containing 1 (from RefSeq NM_024273.2) ENSMUST00000002925.1 ENSMUST00000002925.2 ENSMUST00000002925.3 ENSMUST00000002925.4 ENSMUST00000002925.5 NM_024273 Q8BUY5 Q99LS9 Q9CSI1 TIDC1_MOUSE Timmdc1 uc012afp.1 uc012afp.2 uc012afp.3 Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I (By similarity). Associates with the intermediate 315 kDa subcomplex of incompletely assembled complex I. Interacts with TMEM70 (By similarity). Mitochondrion membrane ; Multi-pass membrane protein Belongs to the Tim17/Tim22/Tim23 family. molecular_function nucleus nucleoplasm mitochondrion biological_process membrane integral component of membrane mitochondrial membrane uc012afp.1 uc012afp.2 uc012afp.3 
ENSMUST00000002926.8 Pla1a ENSMUST00000002926.8 phospholipase A1 member A (from RefSeq NM_134102.4) E9QN71 ENSMUST00000002926.1 ENSMUST00000002926.2 ENSMUST00000002926.3 ENSMUST00000002926.4 ENSMUST00000002926.5 ENSMUST00000002926.6 ENSMUST00000002926.7 NM_134102 PLA1A_MOUSE Pla1a Pspla1 Q8VI78 Q99J51 uc007zew.1 uc007zew.2 Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1- acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (By similarity). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production. Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl- sn-glycero-3-phospho-L-serine + a fatty acid + H(+); Xref=Rhea:RHEA:42212, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57262, ChEBI:CHEBI:65214; EC=3.1.1.111; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42213; Evidence=; Reaction=1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L- serine + H(+); Xref=Rhea:RHEA:40491, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74905, ChEBI:CHEBI:77342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40492; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phospho-L-serine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phospho-L-serine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41187, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:75032, ChEBI:CHEBI:77830; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41188; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a fatty acid + H(+) + sn-glycero-3-phospho-L-serine; Xref=Rhea:RHEA:32979, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:64379, ChEBI:CHEBI:64765; EC=3.1.1.111; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32980; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine; Xref=Rhea:RHEA:40499, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:64765, ChEBI:CHEBI:74617; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40500; Evidence=; Secreted Belongs to the AB hydrolase superfamily. Lipase family. acrosomal membrane extracellular region extracellular space lipid metabolic process phosphatidylcholine 1-acylhydrolase activity lipid catabolic process lipase activity hydrolase activity carboxylic ester hydrolase activity uc007zew.1 uc007zew.2 
ENSMUST00000002976.5 Il17ra ENSMUST00000002976.5 interleukin 17 receptor A (from RefSeq NM_008359.2) ENSMUST00000002976.1 ENSMUST00000002976.2 ENSMUST00000002976.3 ENSMUST00000002976.4 I17RA_MOUSE Il17r NM_008359 Q60943 uc009dnj.1 uc009dnj.2 uc009dnj.3 uc009dnj.4 Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:20554964, PubMed:8777726, PubMed:27923703). Receptor for IL17F (PubMed:17911633, PubMed:20554964). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (By similarity). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (By similarity). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (By similarity). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (PubMed:21993848, PubMed:20364087). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (PubMed:18157131). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity (PubMed:27795421). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (PubMed:26735852). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848, PubMed:21993849, PubMed:21982598). (Microbial infection) Receptor for SARS coronavirus-2/SARS- CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF- kappa-B signaling pathway. Forms heterodimers with IL17RC; the heterodimer binds IL17A and IL17F homodimers as well as the heterodimer formed by IL17A and IL17F (PubMed:20554964). Forms complexes with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule (By similarity). IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex, whereas IL17F homodimer forms predominantly complexes with IL17RC homodimer (By similarity). IL17A homodimer adopts an asymmetrical ternary structure with one IL17RA molecule, allowing for high affinity interactions of one IL17A monomer with one IL17RA molecule (via D1 and D2 domains), while disfavoring binding of a second IL17RA molecule on the other IL17A monomer (By similarity). IL17A-IL17F forms complexes with IL17RA- IL17RC, but with lower affinity when compared to IL17A homodimer (By similarity). IL17RA chain cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (By similarity). Interacts with TRAF3IP2 (By similarity). Forms heterodimers with IL17RE; the heterodimer binds IL17C (PubMed:21993848). (Microbial infection) Interacts with SARS coronavirus-2/SARS- CoV-2 virus protein ORF8. Cell membrane ; Single-pass type I membrane protein Widely expressed (PubMed:21993848). Highly expressed in T cells and macrophages (PubMed:19144317). Highly expressed in B-1a B cells and at a lower extent in B-1b and B-2 B cells (at protein level) (PubMed:26735852). Up-regulated in brain upon West Nile virus infection. Mutant mice are susceptibile to S.aureus cutaneous infection (PubMed:20364087). Mutant mice are susceptible to A. fumigatus pulmonary infection characterized by excessive mucus production, goblet cell hyperplasia and exacerbated T-helper 2 allergic inflammation (PubMed:28813677). receptor binding plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway interleukin-17 receptor activity positive regulation of interleukin-23 production positive regulation of inflammatory response defense response to fungus cellular response to cytokine stimulus granulocyte chemotaxis fibroblast activation positive regulation of cytokine production involved in inflammatory response positive regulation of interleukin-5 secretion positive regulation of interleukin-13 secretion uc009dnj.1 uc009dnj.2 uc009dnj.3 uc009dnj.4 
ENSMUST00000002979.16 Lamb1 ENSMUST00000002979.16 laminin B1 (from RefSeq NM_008482.3) E9PXZ9 ENSMUST00000002979.1 ENSMUST00000002979.10 ENSMUST00000002979.11 ENSMUST00000002979.12 ENSMUST00000002979.13 ENSMUST00000002979.14 ENSMUST00000002979.15 ENSMUST00000002979.2 ENSMUST00000002979.3 ENSMUST00000002979.4 ENSMUST00000002979.5 ENSMUST00000002979.6 ENSMUST00000002979.7 ENSMUST00000002979.8 ENSMUST00000002979.9 LAMB1_MOUSE Lamb-1 Lamb1-1 NM_008482 P02469 uc007nhd.1 uc007nhd.2 uc007nhd.3 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of the cerebral cortex (By similarity). It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons (By similarity). Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface (By similarity). Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin- 211 or merosin), laminin-6 (laminin-311 or K-laminin), laminin-8 (laminin-411), laminin-10 (laminin-511) and laminin-12 (laminin-213) (By similarity). Interacts with ITGB1 (PubMed:34427057). P02469; P02468: Lamc1; NbExp=4; IntAct=EBI-6662997, EBI-7059830; P02469; P31696: AGRN; Xeno; NbExp=2; IntAct=EBI-6662997, EBI-457650; Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. Widely expressed in the embryo. High levels are detected in the cerebellar basement membrane, at postnatal day 7. Sequence=AAA39407.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; integrin binding extracellular matrix structural constituent protein binding extracellular region basement membrane laminin-1 complex laminin-2 complex extracellular space nucleus cell adhesion negative regulation of cell adhesion embryo implantation learning or memory animal organ morphogenesis tissue development cell migration enzyme binding neuronal-glial interaction involved in cerebral cortex radial glia guided migration positive regulation of cell migration extracellular matrix neuron projection development substrate adhesion-dependent cell spreading odontogenesis glycosphingolipid binding laminin complex laminin-8 complex laminin-10 complex perinuclear region of cytoplasm basement membrane assembly uc007nhd.1 uc007nhd.2 uc007nhd.3 
ENSMUST00000002989.11 Arrdc2 ENSMUST00000002989.11 arrestin domain containing 2 (from RefSeq NM_027560.1) ARRD2_MOUSE ENSMUST00000002989.1 ENSMUST00000002989.10 ENSMUST00000002989.2 ENSMUST00000002989.3 ENSMUST00000002989.4 ENSMUST00000002989.5 ENSMUST00000002989.6 ENSMUST00000002989.7 ENSMUST00000002989.8 ENSMUST00000002989.9 NM_027560 Q3UVK8 Q3UXC6 Q9D668 uc009mbt.1 uc009mbt.2 uc009mbt.3 Interacts with WWP1 (via WW domains). Belongs to the arrestin family. molecular_function plasma membrane biological_process cytoplasmic vesicle uc009mbt.1 uc009mbt.2 uc009mbt.3 
ENSMUST00000003017.13 Tbxas1 ENSMUST00000003017.13 thromboxane A synthase 1, platelet, transcript variant 5 (from RefSeq NR_177077.1) Cyp5 Cyp5a1 ENSMUST00000003017.1 ENSMUST00000003017.10 ENSMUST00000003017.11 ENSMUST00000003017.12 ENSMUST00000003017.2 ENSMUST00000003017.3 ENSMUST00000003017.4 ENSMUST00000003017.5 ENSMUST00000003017.6 ENSMUST00000003017.7 ENSMUST00000003017.8 ENSMUST00000003017.9 NR_177077 P36423 P97505 THAS_MOUSE uc009ble.1 uc009ble.2 uc009ble.3 Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Cleaves also PGH2 to 12-hydroxy- heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)- eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE. Reaction=prostaglandin H2 = thromboxane A2; Xref=Rhea:RHEA:17137, ChEBI:CHEBI:57405, ChEBI:CHEBI:57445; EC=5.3.99.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17138; Evidence=; Reaction=prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)- heptadecatrienoate + malonaldehyde; Xref=Rhea:RHEA:48644, ChEBI:CHEBI:57405, ChEBI:CHEBI:90694, ChEBI:CHEBI:566274; Evidence=; Reaction=a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O; Xref=Rhea:RHEA:55556, ChEBI:CHEBI:15377, ChEBI:CHEBI:59720, ChEBI:CHEBI:131859; EC=4.2.1.152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55557; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo- (5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48637; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O; Xref=Rhea:RHEA:48856, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:57409, ChEBI:CHEBI:57446; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48857; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Monomer. Endoplasmic reticulum membrane ; Multi-pass membrane protein Expressed primarily in lung, kidney, and spleen. Deficient mice are viable, fertile and exhibited no gross abnormalities in size, body weight, and anatomical features of major organs. However deficency causes a mild hemostatic defect and protects mice against arachidonate-induced shock and death. Belongs to the cytochrome P450 family. prostaglandin biosynthetic process monooxygenase activity thromboxane-A synthase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen isomerase activity heme binding cellular chloride ion homeostasis response to ethanol positive regulation of vasoconstriction metal ion binding oxidation-reduction process response to fatty acid uc009ble.1 uc009ble.2 uc009ble.3 
ENSMUST00000003029.14 Timm44 ENSMUST00000003029.14 translocase of inner mitochondrial membrane 44 (from RefSeq NM_011592.2) ENSMUST00000003029.1 ENSMUST00000003029.10 ENSMUST00000003029.11 ENSMUST00000003029.12 ENSMUST00000003029.13 ENSMUST00000003029.2 ENSMUST00000003029.3 ENSMUST00000003029.4 ENSMUST00000003029.5 ENSMUST00000003029.6 ENSMUST00000003029.7 ENSMUST00000003029.8 ENSMUST00000003029.9 Mimt44 NM_011592 O35857 Q2NLC5 TIM44_MOUSE Tim44 uc009ktq.1 uc009ktq.2 uc009ktq.3 uc009ktq.4 Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (PubMed:31618756). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). The complex interacts with the TIMM23 component of the TIM23 complex (PubMed:31618756). Interacts with SLC25A4/ANT1 and SLC25A5/ANT2; leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (PubMed:31618756). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the Tim44 family. nucleotide binding ATP binding mitochondrion mitochondrial inner membrane mitochondrial matrix intracellular protein transport protein transport membrane enzyme binding protein import into mitochondrial matrix chaperone binding uc009ktq.1 uc009ktq.2 uc009ktq.3 uc009ktq.4 
ENSMUST00000003038.12 Ap2a2 ENSMUST00000003038.12 adaptor-related protein complex 2, alpha 2 subunit, transcript variant 2 (from RefSeq NM_007459.3) AP2A2_MOUSE Adtab ENSMUST00000003038.1 ENSMUST00000003038.10 ENSMUST00000003038.11 ENSMUST00000003038.2 ENSMUST00000003038.3 ENSMUST00000003038.4 ENSMUST00000003038.5 ENSMUST00000003038.6 ENSMUST00000003038.7 ENSMUST00000003038.8 ENSMUST00000003038.9 NM_007459 P17427 Q8C2J5 Q921V0 uc009kls.1 uc009kls.2 uc009kls.3 uc009kls.4 Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L- [LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non- clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1) (PubMed:19140243). Binds EPN1, EPS15, AMPH, SNAP91 and BIN1 (PubMed:10380931, PubMed:10430869, PubMed:12057195). Interacts with clathrin (PubMed:10459011). Interacts with HIP1 (By similarity). Interacts with DGKD (PubMed:17880279). Interacts with DENND1A, DENND1B and DENND1C (PubMed:20154091). Interacts with FCHO1 and DAB2 (PubMed:11247302, PubMed:22484487). Interacts with ATAT1; this interaction is required for efficient alpha- tubulin acetylation by ATAT1 (PubMed:24097348). Interacts with KIAA1107 (PubMed:29262337). Together with AP2B1 and AP2M1, it interacts with ADAM10; this interaction facilitates ADAM10 endocytosis from the plasma membrane during long-term potentiation in hippocampal neurons (PubMed:23676497). Interacts with CLN3 (via dileucine motif) (By similarity). Interacts with ABCB11; this interaction regulates cell membrane expression of ABCB11 through its internalization in a clathrin-dependent manner and its subsequent degradation (By similarity). Interacts with Cacfd1 (PubMed:29288152). Cell membrane eripheral membrane protein ; Cytoplasmic side Membrane, coated pit ; Peripheral membrane protein ; Cytoplasmic side Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. Expressed in the brain (at protein level). Belongs to the adaptor complexes large subunit family. protein binding plasma membrane clathrin-coated pit intracellular protein transport endocytosis synaptic vesicle lipid binding protein transport membrane vesicle-mediated transport protein kinase binding protein domain specific binding membrane coat AP-2 adaptor complex clathrin adaptor complex secretory granule cytoplasmic vesicle phosphatidylinositol binding clathrin adaptor activity macromolecular complex binding clathrin-dependent endocytosis disordered domain specific binding regulation of hematopoietic stem cell differentiation uc009kls.1 uc009kls.2 uc009kls.3 uc009kls.4 
ENSMUST00000003044.14 Pnkp ENSMUST00000003044.14 polynucleotide kinase 3'- phosphatase, transcript variant 1 (from RefSeq NM_021549.3) ENSMUST00000003044.1 ENSMUST00000003044.10 ENSMUST00000003044.11 ENSMUST00000003044.12 ENSMUST00000003044.13 ENSMUST00000003044.2 ENSMUST00000003044.3 ENSMUST00000003044.4 ENSMUST00000003044.5 ENSMUST00000003044.6 ENSMUST00000003044.7 ENSMUST00000003044.8 ENSMUST00000003044.9 G5E8N7 G5E8N7_MOUSE NM_021549 Pnkp uc009grg.1 uc009grg.2 uc009grg.3 uc009grg.4 nucleus nucleolus mitochondrion DNA repair response to oxidative stress negative regulation of protein ADP-ribosylation kinase activity phosphorylation dephosphorylation positive regulation of telomere maintenance via telomerase DNA damage response, detection of DNA damage polynucleotide 3'-phosphatase activity ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity nucleotide phosphorylation nucleoside monophosphate phosphorylation nucleoside phosphate kinase activity positive regulation of telomerase activity DNA 3' dephosphorylation involved in DNA repair polynucleotide 3' dephosphorylation positive regulation of telomere capping uc009grg.1 uc009grg.2 uc009grg.3 uc009grg.4 
ENSMUST00000003061.14 Bcam ENSMUST00000003061.14 basal cell adhesion molecule (from RefSeq NM_020486.2) BCAM_MOUSE ENSMUST00000003061.1 ENSMUST00000003061.10 ENSMUST00000003061.11 ENSMUST00000003061.12 ENSMUST00000003061.13 ENSMUST00000003061.2 ENSMUST00000003061.3 ENSMUST00000003061.4 ENSMUST00000003061.5 ENSMUST00000003061.6 ENSMUST00000003061.7 ENSMUST00000003061.8 ENSMUST00000003061.9 Gplu Lu NM_020486 Q9ESS5 Q9JKB2 Q9R069 uc009fnf.1 uc009fnf.2 uc009fnf.3 Laminin alpha-5 receptor. May mediate intracellular signaling (By similarity). Membrane ; Single-pass type I membrane protein laminin receptor activity plasma membrane integral component of plasma membrane cell adhesion cell-matrix adhesion protein C-terminus binding cell surface membrane integral component of membrane laminin binding uc009fnf.1 uc009fnf.2 uc009fnf.3 
ENSMUST00000003071.10 Apoc4 ENSMUST00000003071.10 apolipoprotein C-IV (from RefSeq NM_007385.3) APOC4_MOUSE Acl ENSMUST00000003071.1 ENSMUST00000003071.2 ENSMUST00000003071.3 ENSMUST00000003071.4 ENSMUST00000003071.5 ENSMUST00000003071.6 ENSMUST00000003071.7 ENSMUST00000003071.8 ENSMUST00000003071.9 NM_007385 Q61268 uc009fmu.1 uc009fmu.2 uc009fmu.3 uc009fmu.4 May participate in lipoprotein metabolism. Secreted. Expressed by the liver and secreted in plasma. Belongs to the apolipoprotein C4 family. extracellular region lipid transport positive regulation of sequestering of triglyceride very-low-density lipoprotein particle high-density lipoprotein particle triglyceride homeostasis uc009fmu.1 uc009fmu.2 uc009fmu.3 uc009fmu.4 
ENSMUST00000003100.10 Cyp2f2 ENSMUST00000003100.10 cytochrome P450, family 2, subfamily f, polypeptide 2 (from RefSeq NM_007817.2) CP2F2_MOUSE Cyp2f-2 ENSMUST00000003100.1 ENSMUST00000003100.2 ENSMUST00000003100.3 ENSMUST00000003100.4 ENSMUST00000003100.5 ENSMUST00000003100.6 ENSMUST00000003100.7 ENSMUST00000003100.8 ENSMUST00000003100.9 NM_007817 P33267 uc009fuy.1 uc009fuy.2 uc009fuy.3 Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or club cells in lung. Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Club cells in lung and liver. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity response to toxic substance membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen naphthalene metabolic process trichloroethylene metabolic process epoxygenase P450 pathway oxygen binding heme binding organelle membrane exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc009fuy.1 uc009fuy.2 uc009fuy.3 
ENSMUST00000003117.15 Ap1m1 ENSMUST00000003117.15 adaptor-related protein complex AP-1, mu subunit 1 (from RefSeq NM_007456.5) Ap1m1 ENSMUST00000003117.1 ENSMUST00000003117.10 ENSMUST00000003117.11 ENSMUST00000003117.12 ENSMUST00000003117.13 ENSMUST00000003117.14 ENSMUST00000003117.2 ENSMUST00000003117.3 ENSMUST00000003117.4 ENSMUST00000003117.5 ENSMUST00000003117.6 ENSMUST00000003117.7 ENSMUST00000003117.8 ENSMUST00000003117.9 NM_007456 Q3UG16 Q3UG16_MOUSE uc009mfp.1 uc009mfp.2 uc009mfp.3 This gene encodes the mu-1 subunit of the scaffolding adapter protein complex AP-1 and is a member of the mu adaptin family. The AP-1 complex, which consists of 4 subunits (mu-adaptin, beta-prime adaptin, gamma-adaptin, and the small chain adaptin), is one of the predominant coat proteins of membrane vesicles involved in eukaryotic post-Golgi trafficking. The AP-1 complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. AP-1 complex subunit mu-1 and other mu-adaptins select cargo proteins bearing sequence-specific sorting motifs. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK148173.1, M62419.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Belongs to the adaptor complexes medium subunit family. intracellular protein transport protein transport membrane vesicle-mediated transport clathrin adaptor complex melanosome organization endosome to melanosome transport uc009mfp.1 uc009mfp.2 uc009mfp.3 
ENSMUST00000003121.9 Rab8a ENSMUST00000003121.9 RAB8A, member RAS oncogene family (from RefSeq NM_023126.2) ENSMUST00000003121.1 ENSMUST00000003121.2 ENSMUST00000003121.3 ENSMUST00000003121.4 ENSMUST00000003121.5 ENSMUST00000003121.6 ENSMUST00000003121.7 ENSMUST00000003121.8 NM_023126 Q0PD50 Q0PD50_MOUSE Rab8A Rab8a uc009mfk.1 uc009mfk.2 uc009mfk.3 Membrane ; Lipid- anchor ; Cytoplasmic side Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding Golgi apparatus centrosome plasma membrane cilium vesicle docking involved in exocytosis axonogenesis regulation of autophagy postsynaptic density GDP binding protein kinase binding dendrite midbody cytoplasmic vesicle myosin V binding cellular response to insulin stimulus regulation of protein localization neuronal cell body dendritic spine synapse phagocytic vesicle regulation of long-term neuronal synaptic plasticity Golgi vesicle fusion to target membrane regulation of protein transport recycling endosome membrane cilium assembly protein localization to plasma membrane non-motile cilium neurotransmitter receptor transport, endosome to postsynaptic membrane neurotransmitter receptor transport to postsynaptic membrane glutamatergic synapse vesicle-mediated transport in synapse uc009mfk.1 uc009mfk.2 uc009mfk.3 
ENSMUST00000003123.10 Fam32a ENSMUST00000003123.10 family with sequence similarity 32, member A (from RefSeq NM_026455.5) ENSMUST00000003123.1 ENSMUST00000003123.2 ENSMUST00000003123.3 ENSMUST00000003123.4 ENSMUST00000003123.5 ENSMUST00000003123.6 ENSMUST00000003123.7 ENSMUST00000003123.8 ENSMUST00000003123.9 FA32A_MOUSE MNCb-3154 NM_026455 Otag12 Q8K5E4 Q9CR80 uc009mfn.1 uc009mfn.2 uc009mfn.3 May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth. Nucleus Widely expressed, with highest level in pancreas and lowest in muscle. Belongs to the FAM32 family. nucleus nucleolus apoptotic process cell cycle biological_process uc009mfn.1 uc009mfn.2 uc009mfn.3 
ENSMUST00000003137.15 Cyp2c29 ENSMUST00000003137.15 cytochrome P450, family 2, subfamily c, polypeptide 29, transcript variant 1 (from RefSeq NM_007815.4) CP2CT_MOUSE Cyp2c29 E9QMD8 ENSMUST00000003137.1 ENSMUST00000003137.10 ENSMUST00000003137.11 ENSMUST00000003137.12 ENSMUST00000003137.13 ENSMUST00000003137.14 ENSMUST00000003137.2 ENSMUST00000003137.3 ENSMUST00000003137.4 ENSMUST00000003137.5 ENSMUST00000003137.6 ENSMUST00000003137.7 ENSMUST00000003137.8 ENSMUST00000003137.9 NM_007815 Q64458 Q8WUN8 uc008hjz.1 uc008hjz.2 uc008hjz.3 A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of 14,15 double bond of (5Z,8Z,11Z,14Z)- eicosatetraenoic acid (arachidonate) forming 14,15-epoxyeicosatrienoic acid (14,15-EET) regioisomer. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase). Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51472, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:84024; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51473; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Lipid metabolism; arachidonate metabolism. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Expressed in liver as well as in extrahepatic tissues including brain, kidney, lung, heart, and intestine. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity retinoic acid 4-hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding organelle membrane caffeine oxidase activity exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity estrogen 16-alpha-hydroxylase activity uc008hjz.1 uc008hjz.2 uc008hjz.3 
ENSMUST00000003152.14 Stk11 ENSMUST00000003152.14 serine/threonine kinase 11, transcript variant 1 (from RefSeq NM_011492.5) A0A2L1DGD8 B3VBP0 ENSMUST00000003152.1 ENSMUST00000003152.10 ENSMUST00000003152.11 ENSMUST00000003152.12 ENSMUST00000003152.13 ENSMUST00000003152.2 ENSMUST00000003152.3 ENSMUST00000003152.4 ENSMUST00000003152.5 ENSMUST00000003152.6 ENSMUST00000003152.7 ENSMUST00000003152.8 ENSMUST00000003152.9 Lkb1 NM_011492 Q3TAE0 Q9WTK7 STK11_MOUSE Stk11 uc007gbu.1 uc007gbu.2 uc007gbu.3 uc007gbu.4 This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]. Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). [Isoform 2]: Has a role in spermiogenesis. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Activated by forming a complex with STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): STRADA (or STRADB)-binding promotes a conformational change of STK11/LKB1 in an active conformation, which is stabilized by CAB39/MO25alpha (or CAB39L/MO25beta) interacting with the STK11/LKB1 activation loop. Sequestration in the nucleus by NR4A1 prevents it from phosphorylating and activating cytoplasmic AMPK (By similarity). Catalytic component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Interacts with p53/TP53, SMAD4, STK11IP and WDR6. Interacts with NR4A1 (By similarity). Interacts with NISCH; this interaction may increase STK11 activity (By similarity). Interacts with PTEN, leading to PTEN phosphorylation (By similarity). Interacts with SIRT1; the interaction deacetylates STK11 (By similarity). Interacts with CDKN1A. Q9WTK7; Q9CSB4: Pard3b; NbExp=2; IntAct=EBI-8627450, EBI-16107395; Q9WTK7; P54646: PRKAA2; Xeno; NbExp=2; IntAct=EBI-8627450, EBI-1383852; Nucleus. Cytoplasm. Membrane. Mitochondrion Note=Translocates to mitochondrion during apoptosis (By similarity). A small fraction localizes at membranes. Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). PTEN promotes cytoplasmic localization (By similarity). [Isoform 2]: Nucleus Cytoplasm Note=Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Event=Alternative splicing; Named isoforms=3; Name=1 Synonyms=LKB1(L), STK11C ; IsoId=Q9WTK7-1; Sequence=Displayed; Name=2 ; Synonyms=LKB1(S); IsoId=Q9WTK7-2; Sequence=VSP_052222, VSP_052223; Name=3; Synonyms=STK11N ; IsoId=Q9WTK7-3; Sequence=VSP_060609, VSP_060610; [Isoform 1]: Widely expressed. [Isoform 2]: Predominantly expressed in testis (at protein level). [Isoform 3]: Expressed in adult brain and liver and absent from tissues derived from postnatal day 7. Ubiquitously expressed 7-11 dpc. Present in nucleated embryonic blood cells from 9 dpc. Restricted to gastrointestinal tract, testis and lung from days 15-19 dpc. Phosphorylated by ATM at Thr-366 following ionizing radiation (IR). Phosphorylation at Ser-431 by RPS6KA1 and/or some PKA is required to inhibit cell growth. Phosphorylation at Ser-431 is also required during neuronal polarization to mediate phosphorylation of BRSK1 and BRSK2. Phosphorylation by PKC/PRKCZ at Ser-399 in isoform 2 promotes metformin (or peroxynitrite)-induced nuclear export of STK11 and activation of AMPK. UV radiation-induced phosphorylation at Thr-366 mediates CDKN1A degradation. Acetylated. Deacetylation at Lys-48 enhances cytoplasmic localization and kinase activity in vitro. Mice die in utero 8.5 to 9.5 dpc due to severe defects in their vasculature: embryos show neural tube defects, mesenchymal cell death, and vascular abnormalities. Extraembryonic development is also severely affected; the mutant placentas exhibit defective labyrinth layer development and the fetal vessels fail to invade the placenta. Male mice specifically lacking isoform 2 are sterile (PubMed:18774945). A specifically deletion in liver results in hyperglycemia with increased gluconeogenic and lipogenic gene expression due to loss of AMPK phosphorylation and subsequent dephosphorylation of CRTC2/TORC2 (PubMed:16308421). Use of a conditional allele, leads to defects in defects in axon formation with a thinner cortical wall and larger lateral ventricles in the brain cortex (PubMed:17482548). Heterozygous mice develop multiple gastric adenomatous polyps, with polyps remarkably similar to hamartomas of PJS patients both macroscopically and histologically. Polyps in the heterozygous mice are detected at 5 months, and cause premature lethality progressively from 8 months onwards. Polyps are most frequently observed in the stomach where they typically concentrate close to the pylorus. Polyps in the small and large intestine are significantly less frequent. The histology of the polyps in the heterozygous mice is remarkably similar to PJS polyps including the relative contribution of well-differentiated epithelium, and a prominent smooth muscle component. Ptgs2/Cox2 is highly up-regulated in heterozygous mice polyps concomitantly with activation of the extracellular signal-regulated kinases Mapk1/Erk2 and Mapk3/Erk1: treatment with celecoxib Ptgs2/Cox2 inhibitor significantly reduces the total polyp burden. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. nucleotide binding magnesium ion binding regulation of cell growth tissue homeostasis vasculature development p53 binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm mitochondrion cytosol protein phosphorylation protein dephosphorylation autophagy apoptotic process cellular response to DNA damage stimulus cell cycle cell cycle arrest spermatogenesis spermatid development axonogenesis negative regulation of cell proliferation response to ionizing radiation positive regulation of autophagy membrane kinase activity phosphorylation transferase activity establishment of cell polarity regulation of Wnt signaling pathway cell differentiation LRR domain binding protein kinase activator activity negative regulation of cell growth positive regulation of transforming growth factor beta receptor signaling pathway activation of protein kinase activity macromolecular complex response to lipid glucose homeostasis anoikis macromolecular complex binding positive thymic T cell selection positive regulation of gluconeogenesis protein autophosphorylation metal ion binding regulation of dendrite morphogenesis positive regulation of axonogenesis T cell receptor signaling pathway protein heterooligomerization Golgi localization regulation of protein kinase B signaling canonical Wnt signaling pathway negative regulation of epithelial cell proliferation involved in prostate gland development cellular response to UV-B intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of canonical Wnt signaling pathway dendrite extension positive regulation of protein localization to nucleus negative regulation of TORC1 signaling uc007gbu.1 uc007gbu.2 uc007gbu.3 uc007gbu.4 
ENSMUST00000003154.7 Efna2 ENSMUST00000003154.7 ephrin A2 (from RefSeq NM_007909.3) EFNA2_MOUSE ENSMUST00000003154.1 ENSMUST00000003154.2 ENSMUST00000003154.3 ENSMUST00000003154.4 ENSMUST00000003154.5 ENSMUST00000003154.6 Elf1 Epl6 Eplg6 Lerk6 NM_007909 P52801 uc007gcg.1 uc007gcg.2 uc007gcg.3 Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8. Cell membrane ; Lipid-anchor, GPI- anchor Expressed in myogenic progenitor cells. In myogenic progenitor cells, highly expressed, at least as early as 11.5 dpc, expression decreases gradually until adulthood. Belongs to the ephrin family. protein binding plasma membrane axon guidance membrane olfactory bulb development osteoclast differentiation anchored component of membrane neuromuscular junction perikaryon bone remodeling ephrin receptor binding ephrin receptor signaling pathway uc007gcg.1 uc007gcg.2 uc007gcg.3 
ENSMUST00000003183.12 Ppp5c ENSMUST00000003183.12 protein phosphatase 5, catalytic subunit, transcript variant 4 (from RefSeq NR_184427.1) ENSMUST00000003183.1 ENSMUST00000003183.10 ENSMUST00000003183.11 ENSMUST00000003183.2 ENSMUST00000003183.3 ENSMUST00000003183.4 ENSMUST00000003183.5 ENSMUST00000003183.6 ENSMUST00000003183.7 ENSMUST00000003183.8 ENSMUST00000003183.9 G5E819 NR_184427 O35299 PPP5_MOUSE Q60676 uc009fiq.1 uc009fiq.2 uc009fiq.3 uc009fiq.4 uc009fiq.5 Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:17376776, PubMed:21994940, PubMed:22526606). Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (By similarity). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (PubMed:17376776). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (By similarity). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function (PubMed:21994940). Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (PubMed:21994940). Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT (By similarity). Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (By similarity). Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (By similarity). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20630; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47005; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 Mg(2+) or Mn(2+) cations per subunit. ; Autoinhibited. In the autoinhibited state, the TPR domain interacts with the catalytic region and prevents substrate access to the catalytic pocket. Allosterically activated by various polyunsaturated fatty acids, free long-chain fatty-acids and long-chain fatty acyl-CoA esters, arachidonic acid being the most effective activator. HSP90A and probably RAC1, GNA12 and GNA13 can also release the autoinhibition by the TPR repeat. Activation by RAC1, GNA12 and GNA13 is synergistic with the one produced by fatty acids binding. Inhibited by okadaic acid. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (By similarity). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (By similarity). Part of a complex with HSP90/HSP90AA1 and steroid receptors (PubMed:9195923). Interacts (via TPR repeats) with HSP90AA1 (via TPR repeat-binding motif) or HSPA1A/HSPA1B; the interaction is direct and activates the phosphatase activity (By similarity). Dissociates from HSPA1A/HSPA1B and HSP90AA1 in response to arachidonic acid (By similarity). Interacts with CPNE1 (via VWFA domain) (PubMed:12522145). Interacts with CDC16, CDC27 (By similarity). Interacts with KLHDC10 (via the 6 Kelch repeats); inhibits the phosphatase activity on MAP3K5 (By similarity). Interacts with ATM and ATR; both interactions are induced by DNA damage and enhance ATM and ATR kinase activity (By similarity). Interacts with RAD17; reduced by DNA damage (By similarity). Interacts with nuclear receptors such as NR3C1/GCR and PPARG (activated by agonist); regulates their transactivation activities (PubMed:9195923, PubMed:21994940). Interacts (via TPR repeats) with S100 proteins S100A1, S100A2, S100A6, S100B and S100P; the interactions are calcium-dependent, strongly activate PPP5C phosphatase activity and compete with HSP90AA1 and MAP3K5 interactions (By similarity). Interacts with SMAD2 and SMAD3 but not with SMAD1; decreases SMAD3 phosphorylation and protein levels (By similarity). Interacts (via TPR repeats) with CRY1 and CRY2; the interaction with CRY2 down-regulates the phosphatase activity on CSNK1E (By similarity). Interacts (via TPR repeats) with the active form of RAC1, GNA12 or GNA13; these interactions activate the phosphatase activity and translocate PPP5C to the cell membrane (By similarity). Interacts with FLCN (By similarity). Nucleus Cytoplasm Cell membrane Note=Predominantly nuclear. But also present in the cytoplasm. Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner. Expressed in liver (at protein level) and brain, enriched in suprachiasmatic nuclei. Does not show circadian oscillation. Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form. Animals are fertile with a growth rate equivalent to that of wild-type. Males weigh less, exhibit reduced fasting glycaemia and improved glucose tolerance, but retain normal insulin sensitivity. Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. negative regulation of protein phosphorylation G-protein alpha-subunit binding RNA binding phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein binding ATP binding nucleus cytoplasm cytosol plasma membrane protein dephosphorylation microtubule binding response to lead ion membrane histone dephosphorylation hydrolase activity phosphatase activity heat shock protein binding macromolecular complex identical protein binding neuron projection neuronal cell body perikaryon intracellular membrane-bounded organelle response to morphine ADP binding metal ion binding protein oligomerization protein heterooligomerization Hsp90 protein binding negative regulation of cell death cellular response to hydrogen peroxide cellular response to cadmium ion cell periphery negative regulation of neuron death response to arachidonic acid proximal dendrite positive regulation of glucocorticoid receptor signaling pathway uc009fiq.1 uc009fiq.2 uc009fiq.3 uc009fiq.4 uc009fiq.5 
ENSMUST00000003207.11 Lipe ENSMUST00000003207.11 lipase, hormone sensitive, transcript variant 1 (from RefSeq NM_010719.5) ENSMUST00000003207.1 ENSMUST00000003207.10 ENSMUST00000003207.2 ENSMUST00000003207.3 ENSMUST00000003207.4 ENSMUST00000003207.5 ENSMUST00000003207.6 ENSMUST00000003207.7 ENSMUST00000003207.8 ENSMUST00000003207.9 LIPS_MOUSE NM_010719 P54310 P97866 Q3TE34 Q6GU16 Q8CDI9 uc009fsr.1 uc009fsr.2 uc009fsr.3 Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed:15550674, PubMed:20625037, PubMed:21454566, PubMed:23066022, PubMed:23291629). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and of the fatty acid (FA) esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Preferentially hydrolyzes FA esters at the sn-3 position of the glycerol backbone in DAGs (PubMed:23066022). Catalyzes the hydrolysis of 2- arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:20625037, PubMed:21454566). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity). Reaction=a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+); Xref=Rhea:RHEA:32731, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17408, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.79; Evidence=; Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.79; Evidence=; Reaction=a monoacylglycerol + H2O = a fatty acid + glycerol + H(+); Xref=Rhea:RHEA:15245, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17408, ChEBI:CHEBI:17754, ChEBI:CHEBI:28868; EC=3.1.1.79; Evidence=; Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.; EC=3.1.1.23; Evidence=; Reaction=cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+); Xref=Rhea:RHEA:33875, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30823, ChEBI:CHEBI:46898; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33876; Evidence=; Reaction=all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate; Xref=Rhea:RHEA:13933, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13934; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38455, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52323, ChEBI:CHEBI:75937; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38456; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26133; Evidence=; Reaction=1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38488; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38491, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:73990; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38492; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn- glycerol + acetate + H(+); Xref=Rhea:RHEA:38563, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:34115, ChEBI:CHEBI:75936; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38564; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)- octadecenoate + (9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:39935, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52333, ChEBI:CHEBI:75937; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39936; Evidence=; Reaction=1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:39939, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75735, ChEBI:CHEBI:75937; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39940; Evidence=; Reaction=(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O; Xref=Rhea:RHEA:38379, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52323, ChEBI:CHEBI:53753; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38381; Evidence=; Reaction=2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)- octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38383, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:73990, ChEBI:CHEBI:75824; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38384; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + di-(9Z)-octadecenoylglycerol + H(+); Xref=Rhea:RHEA:38575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38576; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38659, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52323, ChEBI:CHEBI:73990; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38660; Evidence=; Kinetic parameters: KM=0.25 uM for 1-(9Z-octadecenoyl)-glycerol ; KM=0.26 uM for 2-(9Z-octadecenoyl)-glycerol ; KM=0.27 uM for 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol ; Glycerolipid metabolism; triacylglycerol degradation. Monomer and homodimer (By similarity). Interacts with CAVIN1 in the adipocyte cytoplasm (By similarity). Interacts with PLIN5 (PubMed:19717842). Cell membrane Membrane, caveola Cytoplasm, cytosol Lipid droplet Note=Found in the high-density caveolae (By similarity). Translocates to the cytoplasm from the caveolae upon insulin stimulation (By similarity). Phosphorylation by AMPK reduces its translocation towards the lipid droplets. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P54310-1; Sequence=Displayed; Name=2; IsoId=P54310-2; Sequence=VSP_053335; Phosphorylation by AMPK reduces its translocation towards the lipid droplets. Total acylglycerol levels are unaltered whereas diacylglycerol concentrations are drastically increased in white adipose tissue of knockout mice when compared to wild-type littermates. Belongs to the 'GDXG' lipolytic enzyme family. triglyceride lipase activity protein binding extracellular space nucleus cytoplasm mitochondrion lipid particle cytosol plasma membrane caveola transcription initiation from RNA polymerase I promoter termination of RNA polymerase I transcription lipid metabolic process steroid metabolic process cholesterol metabolic process membrane lipid catabolic process lipase activity hydrolase activity hydrolase activity, acting on ester bonds serine hydrolase activity triglyceride catabolic process protein kinase binding hormone-sensitive lipase activity rRNA primary transcript binding long-chain fatty acid catabolic process diacylglycerol catabolic process acylglycerol lipase activity uc009fsr.1 uc009fsr.2 uc009fsr.3 
ENSMUST00000003238.14 Foxj2 ENSMUST00000003238.14 forkhead box J2 (from RefSeq NM_021899.3) ENSMUST00000003238.1 ENSMUST00000003238.10 ENSMUST00000003238.11 ENSMUST00000003238.12 ENSMUST00000003238.13 ENSMUST00000003238.2 ENSMUST00000003238.3 ENSMUST00000003238.4 ENSMUST00000003238.5 ENSMUST00000003238.6 ENSMUST00000003238.7 ENSMUST00000003238.8 ENSMUST00000003238.9 FOXJ2_MOUSE Fhx NM_021899 Q9ES18 uc012esh.1 uc012esh.2 uc012esh.3 Transcriptional activator. Able to bind to two different type of DNA binding sites (By similarity). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (PubMed:11025217, PubMed:15489334). Nucleus Spermtaocytes (at protein level). Expressed in adult brain, heart skeletal muscle, lung, kidney and gonads. Liver, small intestine, and spleen also show expression but at lower levels. In the testis, expressed from pachytene spermatocytes to round spermatids, but not in spermatogonia. In addition to the germ lineage, also expressed in Sertoli cells of the testis. In the ovary, only granulosa cells of the follicles show expression. In the brain, expressed in the piriform cortex, hippocampus, habenula and in the granula cell layer in the cerebellum. Expressed both maternally and zygotically. Zygotic expression first begins in 8-cell stage embryos, with expression increasing in blastocysts. In embryos, both cell layers of the blastocyst: the trophectoderm (TE) and the inner cell mass (ICM) show expression. Male germ-cell-specific conditional knockout results in complete male infertility and meiotic arrest in spermatocytes. Spermatocytes show aberrant chromosomal synapsis and DNA double-strand breaks (DSB) repair and significantly reduced expression of DSB repair-associated genes and meiotic arrest-related genes. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding fibrillar center DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated negative regulation of angiogenesis identical protein binding sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of vascular smooth muscle cell proliferation uc012esh.1 uc012esh.2 uc012esh.3 
ENSMUST00000003268.11 Sh3gl1 ENSMUST00000003268.11 SH3-domain GRB2-like 1, transcript variant 1 (from RefSeq NM_013664.3) ENSMUST00000003268.1 ENSMUST00000003268.10 ENSMUST00000003268.2 ENSMUST00000003268.3 ENSMUST00000003268.4 ENSMUST00000003268.5 ENSMUST00000003268.6 ENSMUST00000003268.7 ENSMUST00000003268.8 ENSMUST00000003268.9 NM_013664 Q62419 SH3G1_MOUSE Sh3d2b uc008daq.1 uc008daq.2 uc008daq.3 uc008daq.4 Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Interacts with ARC, SYNJ1 and DNM1. Interacts with PDCD6IP. Interacts with BIN2 (By similarity). Q62419; P62862: Fau; NbExp=3; IntAct=EBI-642935, EBI-309546; Cytoplasm Early endosome membrane ; Peripheral membrane protein Cell projection, podosome Note=Associated with postsynaptic endosomes in hippocampal neurons. An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. Belongs to the endophilin family. podosome protein binding cytoplasm endosome cytosol endocytosis protein C-terminus binding lipid binding membrane synaptic vesicle uncoating SH3 domain binding phosphatase binding cell junction beta-1 adrenergic receptor binding early endosome membrane identical protein binding cell projection ion channel binding synapse GTPase binding presynapse modulation of excitatory postsynaptic potential glutamatergic synapse postsynaptic density, intracellular component regulation of synaptic vesicle endocytosis positive regulation of synaptic vesicle endocytosis uc008daq.1 uc008daq.2 uc008daq.3 uc008daq.4 
ENSMUST00000003274.8 Ebi3 ENSMUST00000003274.8 Epstein-Barr virus induced gene 3 (from RefSeq NM_015766.2) ENSMUST00000003274.1 ENSMUST00000003274.2 ENSMUST00000003274.3 ENSMUST00000003274.4 ENSMUST00000003274.5 ENSMUST00000003274.6 ENSMUST00000003274.7 Ebi3 NM_015766 Q3U1K3 Q3U1K3_MOUSE uc008daj.1 uc008daj.2 uc008daj.3 cytokine receptor activity membrane cytokine-mediated signaling pathway uc008daj.1 uc008daj.2 uc008daj.3 
ENSMUST00000003284.16 Irf3 ENSMUST00000003284.16 interferon regulatory factor 3, transcript variant 2 (from RefSeq NR_045611.1) ENSMUST00000003284.1 ENSMUST00000003284.10 ENSMUST00000003284.11 ENSMUST00000003284.12 ENSMUST00000003284.13 ENSMUST00000003284.14 ENSMUST00000003284.15 ENSMUST00000003284.2 ENSMUST00000003284.3 ENSMUST00000003284.4 ENSMUST00000003284.5 ENSMUST00000003284.6 ENSMUST00000003284.7 ENSMUST00000003284.8 ENSMUST00000003284.9 Irf3 NR_045611 Q3U9K6 Q3U9K6_MOUSE uc009gsm.1 uc009gsm.2 uc009gsm.3 negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm cytosol regulation of transcription, DNA-templated protein domain specific binding positive regulation of type I interferon production TRIF-dependent toll-like receptor signaling pathway identical protein binding protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter positive regulation of cytokine secretion cellular response to exogenous dsRNA uc009gsm.1 uc009gsm.2 uc009gsm.3 
ENSMUST00000003290.12 Bcl2l12 ENSMUST00000003290.12 BCL2 like 12, transcript variant 3 (from RefSeq NM_029410.4) Bcl2l12 ENSMUST00000003290.1 ENSMUST00000003290.10 ENSMUST00000003290.11 ENSMUST00000003290.2 ENSMUST00000003290.3 ENSMUST00000003290.4 ENSMUST00000003290.5 ENSMUST00000003290.6 ENSMUST00000003290.7 ENSMUST00000003290.8 ENSMUST00000003290.9 NM_029410 Q9D3J3 Q9D3J3_MOUSE uc009gsk.1 uc009gsk.2 uc009gsk.3 uc009gsk.4 Belongs to the Bcl-2 family. p53 binding nucleus apoptotic process regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator inhibition of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cellular senescence uc009gsk.1 uc009gsk.2 uc009gsk.3 uc009gsk.4 
ENSMUST00000003310.7 Ranbp2 ENSMUST00000003310.7 RAN binding protein 2 (from RefSeq NM_011240.3) E9QM01 ENSMUST00000003310.1 ENSMUST00000003310.2 ENSMUST00000003310.3 ENSMUST00000003310.4 ENSMUST00000003310.5 ENSMUST00000003310.6 NM_011240 Q61992 Q8C9K9 Q9ERU9 RBP2_MOUSE uc007fdd.1 uc007fdd.2 uc007fdd.3 uc007fdd.4 E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin- 1. Inhibits EIF4E-dependent mRNA export. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. Protein modification; protein sumoylation. Part of the nuclear pore complex (By similarity). Forms a complex with NXT1, NXF1 and RANGAP1 (By similarity). Forms a tight complex with RANBP1 and UBE2I (By similarity). Interacts with SUMO1 but not SUMO2 (By similarity). Interacts with sumoylated RANGAP1 (By similarity). Interacts with CDCA8 (By similarity). Interacts with PML (By similarity). Interacts with BICD2 (By similarity). Interacts with PRKN (PubMed:16332688). Interacts with MCM3AP (By similarity). Interacts with COX11 (By similarity). Interacts with synaptic plasticity regulator PANTS (PubMed:35771867). Q9ERU9; Q9WVS6: Prkn; NbExp=2; IntAct=EBI-643756, EBI-973635; Nucleus Nucleus membrane Nucleus, nuclear pore complex Nucleus envelope Note=Detected in diffuse and discrete intranuclear foci. Cytoplasmic filaments. Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. The PPIase cyclophilin-type domain has high structural similarity with PPIA, but has extremely low and barely detectable proline isomerase activity (in vitro) (By similarity). Only about half of the residues that surround the PPIA active site cleft are conserved. Polyubiquitinated by PRKN, which leads to proteasomal degradation. The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC. Belongs to the RanBP2 E3 ligase family. Despite the presence of a PPIase cyclophilin-type domain, it has probably no peptidyl-prolyl cis-trans isomerase activity. protein peptidyl-prolyl isomerization response to amphetamine RNA binding peptidyl-prolyl cis-trans isomerase activity protein binding nucleus nuclear envelope annulate lamellae nuclear pore cytoplasm mitochondrion regulation of gluconeogenesis protein folding NLS-bearing protein import into nucleus Ran GTPase binding protein transport membrane transferase activity protein sumoylation SUMO transferase activity nuclear membrane positive regulation of glucokinase activity nuclear inclusion body positive regulation of GTPase activity nuclear pore cytoplasmic filaments nuclear pore nuclear basket macromolecular complex binding metal ion binding intracellular transport mRNA transport centrosome localization cytoplasmic periphery of the nuclear pore complex GTPase activator activity uc007fdd.1 uc007fdd.2 uc007fdd.3 uc007fdd.4 
ENSMUST00000003312.5 Edar ENSMUST00000003312.5 ectodysplasin-A receptor (from RefSeq NM_010100.3) Dl EDAR_MOUSE ENSMUST00000003312.1 ENSMUST00000003312.2 ENSMUST00000003312.3 ENSMUST00000003312.4 NM_010100 Q9DC43 Q9R187 uc007fdh.1 uc007fdh.2 uc007fdh.3 uc007fdh.4 Receptor for EDA isoform TAA, but not for EDA isoform TA-2 (By similarity). May mediate the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. Binds to EDARADD. Associates with TRAF1, TRAF2, TRAF3 and NIK. Membrane ; Single-pass type I membrane protein Transcripts are not detectable in the branchial arch epithelium before morphological tooth formation (10 dpc), but are highly expressed during the initiation of tooth development (11 dpc). Starting 12 dpc, expression is high and limited to the budding cells, and remains high in the fully developed enamel knot at 14 dpc, whereas all other dental cells were completely negative. During 15 dpc the enamel knot disappears largely through apoptosis, and no transcripts were detected in the tooth germs of newborns. In skin, uniformly distributed in the basal cells of the epidermis before follicle initiation. Expression becomes focally elevated before placodes become distinguishable. By 17 dpc transcripts are almost exclusively confined to maturing follicles and the recently initiated placodes. By activin A in 12 dpc dental epithelium. Note=Defects in Edar are a cause of the downless phenotype in mice (the equivalent of anhidrotic ectodermal dysplasia in humans). The disease is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. Sequence=BAB23385.1; Type=Erroneous initiation; Evidence=; hair follicle development transmembrane signaling receptor activity plasma membrane apoptotic process multicellular organism development positive regulation of gene expression membrane integral component of membrane cell differentiation signaling receptor activity odontogenesis of dentin-containing tooth positive regulation of I-kappaB kinase/NF-kappaB signaling pigmentation apical part of cell positive regulation of JNK cascade salivary gland cavitation positive regulation of NIK/NF-kappaB signaling uc007fdh.1 uc007fdh.2 uc007fdh.3 uc007fdh.4 
ENSMUST00000003313.10 Grk5 ENSMUST00000003313.10 G protein-coupled receptor kinase 5 (from RefSeq NM_018869.3) ENSMUST00000003313.1 ENSMUST00000003313.2 ENSMUST00000003313.3 ENSMUST00000003313.4 ENSMUST00000003313.5 ENSMUST00000003313.6 ENSMUST00000003313.7 ENSMUST00000003313.8 ENSMUST00000003313.9 GRK5_MOUSE Gprk5 NM_018869 O70292 O70297 Q8VEB1 uc008ice.1 uc008ice.2 uc008ice.3 uc008ice.4 uc008ice.5 uc008ice.6 Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro). Reaction=[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+); Xref=Rhea:RHEA:12008, Rhea:RHEA- COMP:11260, Rhea:RHEA-COMP:11261, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.16; Inhibited by calmodulin with an IC(50) of 50 nM. Calmodulin inhibits GRK5 association with receptor and phospholipid (By similarity). Interacts with ST13 (via the C-terminus 303-319 AA) (By similarity). Interacts with TP53/p53 (By similarity). Interacts with HTR4 (via C-terminus 330-346 AA); this interaction is promoted by 5-HT (serotonin) (PubMed:18711143). Interacts with HDAC5 (By similarity). Interacts with GIT1 (By similarity). Q8VEB1; Q9UQL6: HDAC5; Xeno; NbExp=2; IntAct=EBI-8367081, EBI-715576; Cytoplasm Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane, targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion (By similarity). Autophosphorylated. Autophosphorylation may play a critical role in the regulation of GRK5 kinase activity. No obvious phenotype due to the redundancy of GRK subtypes in the regulation of GPCR signaling. Deficient mice are viable and showed no anatomic or behavioral abnormalities, only a slight decrease in body temperature. However deficient mice shown altered central and lung M2 muscarinic receptor regulation, with normal heart M2 receptor regulation. GRK5 deficiency leads to a reduced hippocampal acetylcholine release and cholinergic hypofunction by selective impairment of desensitization of presynaptic M2/M4 autoreceptors and promotes amyloid-beta accumulation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. nucleotide binding desensitization of G-protein coupled receptor protein signaling pathway protein kinase activity protein serine/threonine kinase activity G-protein coupled receptor kinase activity protein binding ATP binding nucleus cytoplasm cytosol plasma membrane protein phosphorylation apoptotic process signal transduction tachykinin receptor signaling pathway regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation lipid binding membrane Wnt signaling pathway kinase activity phosphorylation nuclear speck transferase activity nuclear membrane negative regulation of apoptotic process fat cell differentiation protein autophosphorylation beta-adrenergic receptor kinase activity regulation of cell cycle uc008ice.1 uc008ice.2 uc008ice.3 uc008ice.4 uc008ice.5 uc008ice.6 
ENSMUST00000003318.13 Dvl3 ENSMUST00000003318.13 dishevelled segment polarity protein 3, transcript variant 1 (from RefSeq NM_007889.4) DVL3_MOUSE ENSMUST00000003318.1 ENSMUST00000003318.10 ENSMUST00000003318.11 ENSMUST00000003318.12 ENSMUST00000003318.2 ENSMUST00000003318.3 ENSMUST00000003318.4 ENSMUST00000003318.5 ENSMUST00000003318.6 ENSMUST00000003318.7 ENSMUST00000003318.8 ENSMUST00000003318.9 G5E820 NM_007889 Q61062 uc007ypw.1 uc007ypw.2 uc007ypw.3 Involved in the signal transduction pathway mediated by multiple Wnt genes. Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2. Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD. Interacts with CEP164 and DAB2. Interacts with DCDC2. Interacts with FOXK1 and FOXK2 (By similarity). Interacts with DAAM2 (PubMed:22227309). Q61062; O35625: Axin1; NbExp=2; IntAct=EBI-1538450, EBI-2365912; Q61062; Q60838: Dvl2; NbExp=3; IntAct=EBI-1538450, EBI-641940; Q61062; Q80Z96: Vangl1; NbExp=2; IntAct=EBI-1538450, EBI-1750708; Q61062; Q91ZD4: Vangl2; NbExp=2; IntAct=EBI-1538450, EBI-1750744; Cytoplasm Ubiquitous. Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'- linked ubiquitin chains (By similarity). Phosphorylated by CSNK1D. Arginine methylation may function as a switch in regulation of function in Wnt signaling. Belongs to the DSH family. nuclear chromatin positive regulation of protein phosphorylation protease binding heart morphogenesis outflow tract septum morphogenesis receptor binding frizzled binding protein binding cytoplasm cytosol multicellular organism development beta-catenin binding Wnt signaling pathway protein binding, bridging intracellular signal transduction non-canonical Wnt signaling pathway non-canonical Wnt signaling pathway via JNK cascade positive regulation of JUN kinase activity positive regulation of GTPase activity synapse positive regulation of transcription, DNA-templated protein heterodimerization activity Rac GTPase binding protein stabilization canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway cochlea morphogenesis planar cell polarity pathway involved in neural tube closure glutamatergic synapse regulation of cellular protein localization midbrain dopaminergic neuron differentiation Wnt signalosome uc007ypw.1 uc007ypw.2 uc007ypw.3 
ENSMUST00000003319.6 Abcf3 ENSMUST00000003319.6 ATP-binding cassette, sub-family F member 3, transcript variant 2 (from RefSeq NR_190180.1) ABCF3_MOUSE ENSMUST00000003319.1 ENSMUST00000003319.2 ENSMUST00000003319.3 ENSMUST00000003319.4 ENSMUST00000003319.5 NR_190180 Q8K268 Q9JL49 uc007ypz.1 uc007ypz.2 uc007ypz.3 Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. Lacks transmembrane domains and is probably not involved in transport. Sequence=AAF31421.1; Type=Frameshift; Evidence=; nucleotide binding protein binding ATP binding ATPase activity defense response to virus uc007ypz.1 uc007ypz.2 uc007ypz.3 
ENSMUST00000003320.14 Eif2b5 ENSMUST00000003320.14 eukaryotic translation initiation factor 2B, subunit 5 epsilon, transcript variant 8 (from RefSeq NR_184410.1) EI2BE_MOUSE ENSMUST00000003320.1 ENSMUST00000003320.10 ENSMUST00000003320.11 ENSMUST00000003320.12 ENSMUST00000003320.13 ENSMUST00000003320.2 ENSMUST00000003320.3 ENSMUST00000003320.4 ENSMUST00000003320.5 ENSMUST00000003320.6 ENSMUST00000003320.7 ENSMUST00000003320.8 ENSMUST00000003320.9 NR_184410 Q3TU39 Q8CHW4 uc007ypu.1 uc007ypu.2 uc007ypu.3 uc007ypu.4 Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. Activated by the chemical integrated stress response (ISR) inhibitor ISRIB which stimulates guanine nucleotide exchange factor activity for both phosphorylated and unphosphorylated eIF2. Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides. Cytoplasm, cytosol Phosphorylated at Ser-540 by DYRK2; this is required for subsequent phosphorylation by GSK3B. Phosphorylated on serine and threonine residues by GSK3B; phosphorylation inhibits its function (By similarity). Polyubiquitinated, probably by NEDD4. Belongs to the eIF-2B gamma/epsilon subunits family. ovarian follicle development translation initiation factor activity guanyl-nucleotide exchange factor activity nucleus cytoplasm cytosol eukaryotic translation initiation factor 2B complex translation translational initiation aging response to heat response to glucose response to lithium ion astrocyte development oligodendrocyte development hippocampus development translation initiation factor binding response to endoplasmic reticulum stress myelination positive regulation of apoptotic process response to peptide hormone positive regulation of translation positive regulation of translational initiation astrocyte differentiation T cell receptor signaling pathway uc007ypu.1 uc007ypu.2 uc007ypu.3 uc007ypu.4 
ENSMUST00000003360.10 Car11 ENSMUST00000003360.10 carbonic anhydrase 11, transcript variant 4 (from RefSeq NR_177999.1) Car11 ENSMUST00000003360.1 ENSMUST00000003360.2 ENSMUST00000003360.3 ENSMUST00000003360.4 ENSMUST00000003360.5 ENSMUST00000003360.6 ENSMUST00000003360.7 ENSMUST00000003360.8 ENSMUST00000003360.9 NR_177999 Q541E9 Q541E9_MOUSE uc009gwr.1 uc009gwr.2 uc009gwr.3 uc009gwr.4 Does not have a catalytic activity. Secreted Belongs to the alpha-carbonic anhydrase family. carbonate dehydratase activity zinc ion binding uc009gwr.1 uc009gwr.2 uc009gwr.3 uc009gwr.4 
ENSMUST00000003369.10 Plag1 ENSMUST00000003369.10 pleiomorphic adenoma gene 1 (from RefSeq NM_019969.3) B1AXC4 ENSMUST00000003369.1 ENSMUST00000003369.2 ENSMUST00000003369.3 ENSMUST00000003369.4 ENSMUST00000003369.5 ENSMUST00000003369.6 ENSMUST00000003369.7 ENSMUST00000003369.8 ENSMUST00000003369.9 NM_019969 PLAG1_MOUSE Q3UXC0 Q9QYE0 uc008rwp.1 uc008rwp.2 uc008rwp.3 uc008rwp.4 Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Cooperates with CBFB-MYH11. Interacts with KPNA2, which escorts protein to the nucleus via interaction with nuclear localization signal. Interacts with E3 SUMO- protein ligase PIAS1, PIAS2 and PIAS4 (By similarity). Nucleus. Note=Strong nucleolar localization when sumoylation is inhibited. Expressed in heart, spleen, lung, kidney, brain, testis and epididymis but not in salivary glands. High fetal expression with a strong decline after birth. Expressed at 9.5 dpc and 10.5 dpc in nervous system with highest level in telencephalon, diencephalon, and midbrain, as well as regionalized expression in the neural tube, which is characteristic of genes involved in the specification of neuronal fates. C2H2-type zinc fingers 3 interacts with DNA-binding site G- clusterinc fingers. C2H2-type zinc fingers 6 and 7 interact with DNA- binding site core sequence (By similarity). Sumoylated with SUMO1; which inhibits transcriptional activity, but does not affect nuclear localization. Blockers of sumoylation pathway such as SENP3 and inactive UBE2I increases transcriptional capacity. Sumoylation is increased in the presence of PIAS1 (By similarity). Acetylated by lysine acetyltransferase EP300; which activates transcriptional capacity. Lysine residues that are sumoylated also seem to be target for acetylation (By similarity). Mice exhibit growth retardation with lower birth weight and disproportionally small seminal vesicles and ventral prostate as well as decreased fertility in both male and female. However, IGFII expression is normal in embryos. Mice overexpressing Plag1 develop normally with high Plag1 transgene expression in salivary glands, spleen and weak mammary gland detection. They develop salivary gland tumors with major pathological features of human pleimorphic adenomas at the age of 1-5 months. Mice with Plag1 overexpression targeted to salivary and mammary gland develop multifocal salivary gland tumors with pathological features of human pleimorphic adenomas at the age of 5 weeks, as well as mammary gland tumors at the age of 1 year. Plag1 overexpression in salivary gland are accompanied by increased IGFII expression. Besides features characteristic of benign pleimorphic adenomas, malignant characteristics are also observed in salivary gland tumors as well as metastasis to the lungs, reinforcing the tumorigenic role of Plag1. Neonate mice carrying a human myeloid leukemia translocation-associated fusion gene CBFB-MYH11, injected with a retrovirus (4070A), develop the pathology within 2-5 months due to few viral insertions in some genes, such as PLAG1. Insertions near the transcription start site of PLAG1 are predominant in the related tumors and probably participate in the transformation process. Plag1 is one candidate gene that can cooperate with CBFB-MYH11 for leukemogenesis in this mouse model. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAE22643.1; Type=Erroneous initiation; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of gene expression negative regulation of gene expression nuclear speck gland morphogenesis multicellular organism growth organ growth positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of glial cell proliferation prostate gland growth uc008rwp.1 uc008rwp.2 uc008rwp.3 uc008rwp.4 
ENSMUST00000003386.7 Mrpl4 ENSMUST00000003386.7 mitochondrial ribosomal protein L4, transcript variant 2 (from RefSeq NM_023167.2) ENSMUST00000003386.1 ENSMUST00000003386.2 ENSMUST00000003386.3 ENSMUST00000003386.4 ENSMUST00000003386.5 ENSMUST00000003386.6 MNCb-3848 NM_023167 Q811L8 Q8JZU9 Q9DCU6 Q9JJB3 RM04_MOUSE uc009ojv.1 uc009ojv.2 uc009ojv.3 uc009ojv.4 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with MIEF1 upstream open reading frame protein. Mitochondrion Belongs to the universal ribosomal protein uL4 family. Sequence=AAH37064.1; Type=Erroneous initiation; Evidence=; Sequence=BAA95082.1; Type=Frameshift; Evidence=; structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation uc009ojv.1 uc009ojv.2 uc009ojv.3 uc009ojv.4 
ENSMUST00000003395.10 Pde4a ENSMUST00000003395.10 phosphodiesterase 4A, cAMP specific, transcript variant 1 (from RefSeq NM_019798.6) ENSMUST00000003395.1 ENSMUST00000003395.2 ENSMUST00000003395.3 ENSMUST00000003395.4 ENSMUST00000003395.5 ENSMUST00000003395.6 ENSMUST00000003395.7 ENSMUST00000003395.8 ENSMUST00000003395.9 NM_019798 O89084 PDE4A_MOUSE Q8R078 Q9JHQ4 Q9QX48 Q9QX49 Q9QXI8 uc009okm.1 uc009okm.2 uc009okm.3 uc009okm.4 Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. [Isoform 2]: Efficiently hydrolyzes cAMP. [Isoform 2]: Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions. ; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 divalent metal cations per subunit (By similarity). Site 2 has a preference for magnesium and/or manganese ions (By similarity). ; [Isoform 2]: Inhibited by rolipram and diazepam. Kinetic parameters: KM=9.2 uM for cAMP ; Vmax=37.9 nmol/min/mg enzyme toward cAMP ; Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. Interacts with LYN (via SH3 domain). Interacts with ARRB2. Cytoplasm, cytosol Membrane; Peripheral membrane protein Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=O89084-1; Sequence=Displayed; Name=2; Synonyms=PDE4A1 ; IsoId=O89084-2; Sequence=VSP_004563, VSP_004564; Name=3; IsoId=O89084-3; Sequence=VSP_004562; Proteolytically cleaved by CASP3. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. Sequence=AAH27224.2; Type=Erroneous initiation; Evidence=; 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity nucleus nucleoplasm cytoplasm cytosol plasma membrane cAMP catabolic process signal transduction sensory perception of smell phosphoric diester hydrolase activity regulation of protein kinase A signaling membrane hydrolase activity cAMP binding cellular response to drug regulation of cAMP-mediated signaling metal ion binding perinuclear region of cytoplasm modulation of synaptic transmission uc009okm.1 uc009okm.2 uc009okm.3 uc009okm.4 
ENSMUST00000003436.12 Abhd17a ENSMUST00000003436.12 abhydrolase domain containing 17A (from RefSeq NM_145421.2) AB17A_MOUSE Abhd17a D10Bwg1364e ENSMUST00000003436.1 ENSMUST00000003436.10 ENSMUST00000003436.11 ENSMUST00000003436.2 ENSMUST00000003436.3 ENSMUST00000003436.4 ENSMUST00000003436.5 ENSMUST00000003436.6 ENSMUST00000003436.7 ENSMUST00000003436.8 ENSMUST00000003436.9 NM_145421 Q5DU54 Q99JW1 uc007gdv.1 uc007gdv.2 uc007gdv.3 uc007gdv.4 Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towars MAP6. Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; EC=3.1.2.22; Evidence=; Cell membrane ; Lipid-anchor ; Cytoplasmic side Endosome membrane ; Lipid-anchor ; Cytoplasmic side Cell projection, dendritic spine Postsynaptic density membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99JW1-1; Sequence=Displayed; Name=2; IsoId=Q99JW1-2; Sequence=VSP_027272; Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. Sequence=BAD90391.1; Type=Erroneous initiation; Evidence=; protein depalmitoylation endosome plasma membrane palmitoyl-(protein) hydrolase activity endosome membrane postsynaptic density membrane hydrolase activity protein palmitoylation cell junction cell projection dendritic spine synapse postsynaptic membrane recycling endosome membrane protein localization to membrane glutamatergic synapse anchored component of postsynaptic density membrane anchored component of postsynaptic recycling endosome membrane negative regulation of protein localization to microtubule positive regulation of protein localization to endosome uc007gdv.1 uc007gdv.2 uc007gdv.3 uc007gdv.4 
ENSMUST00000003438.11 Mob3a ENSMUST00000003438.11 MOB kinase activator 3A (from RefSeq NM_172457.2) ENSMUST00000003438.1 ENSMUST00000003438.10 ENSMUST00000003438.2 ENSMUST00000003438.3 ENSMUST00000003438.4 ENSMUST00000003438.5 ENSMUST00000003438.6 ENSMUST00000003438.7 ENSMUST00000003438.8 ENSMUST00000003438.9 MOB3A_MOUSE Mobkl2a NM_172457 Q3TBK2 Q8BSU7 uc007geh.1 uc007geh.2 uc007geh.3 May regulate the activity of kinases. Belongs to the MOB1/phocein family. molecular_function biological_process metal ion binding uc007geh.1 uc007geh.2 uc007geh.3 
ENSMUST00000003444.6 Ccdc65 ENSMUST00000003444.6 coiled-coil domain containing 65, transcript variant 1 (from RefSeq NM_153518.2) DRC2_MOUSE Drc2 ENSMUST00000003444.1 ENSMUST00000003444.2 ENSMUST00000003444.3 ENSMUST00000003444.4 ENSMUST00000003444.5 NM_153518 Q6PAP9 Q8VHI7 uc007xnl.1 uc007xnl.2 uc007xnl.3 uc007xnl.4 Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N- DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Component of the nexin-dynein regulatory complex (N-DRC). Interacts with DRC1. Cytoplasm, cytoskeleton, flagellum basal body Cell projection, cilium, flagellum Cytoplasm, cytoskeleton, flagellum axoneme Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VHI7-1; Sequence=Displayed; Name=2; IsoId=Q8VHI7-2; Sequence=VSP_024645; Belongs to the DRC2 family. regulation of cilium movement molecular_function cytoplasm cytoskeleton axonemal dynein complex cilium axoneme motile cilium cell projection cilium assembly cilium-dependent cell motility axonemal dynein complex assembly uc007xnl.1 uc007xnl.2 uc007xnl.3 uc007xnl.4 
ENSMUST00000003445.8 Fkbp11 ENSMUST00000003445.8 FK506 binding protein 11, transcript variant 1 (from RefSeq NM_024169.4) ENSMUST00000003445.1 ENSMUST00000003445.2 ENSMUST00000003445.3 ENSMUST00000003445.4 ENSMUST00000003445.5 ENSMUST00000003445.6 ENSMUST00000003445.7 FKB11_MOUSE NM_024169 Q9CRE4 Q9D1M7 uc007xnm.1 uc007xnm.2 uc007xnm.3 PPIases accelerate the folding of proteins during protein synthesis. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Interacts with IFITM5. Membrane ; Single-pass membrane protein Belongs to the FKBP-type PPIase family. protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity membrane integral component of membrane isomerase activity uc007xnm.1 uc007xnm.2 uc007xnm.3 
ENSMUST00000003450.15 Ddx23 ENSMUST00000003450.15 DEAD box helicase 23 (from RefSeq NM_001080981.1) D3Z0M9 D3Z0M9_MOUSE Ddx23 ENSMUST00000003450.1 ENSMUST00000003450.10 ENSMUST00000003450.11 ENSMUST00000003450.12 ENSMUST00000003450.13 ENSMUST00000003450.14 ENSMUST00000003450.2 ENSMUST00000003450.3 ENSMUST00000003450.4 ENSMUST00000003450.5 ENSMUST00000003450.6 ENSMUST00000003450.7 ENSMUST00000003450.8 ENSMUST00000003450.9 NM_001080981 uc007xne.1 uc007xne.2 uc007xne.3 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Nucleus Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily. mRNA splicing, via spliceosome nucleic acid binding RNA binding ATP binding nucleus U5 snRNP nucleolus U4/U6 x U5 tri-snRNP complex catalytic step 2 spliceosome uc007xne.1 uc007xne.2 uc007xne.3 
ENSMUST00000003451.11 Rnd1 ENSMUST00000003451.11 Rho family GTPase 1 (from RefSeq NM_172612.3) ENSMUST00000003451.1 ENSMUST00000003451.10 ENSMUST00000003451.2 ENSMUST00000003451.3 ENSMUST00000003451.4 ENSMUST00000003451.5 ENSMUST00000003451.6 ENSMUST00000003451.7 ENSMUST00000003451.8 ENSMUST00000003451.9 NM_172612 Q3TSQ9 Q80ZR7 Q8BLR7 Q8BYF2 RND1_MOUSE Rho6 uc007xni.1 uc007xni.2 Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity). Binds GRB7 and PLXNB1. Interacts with PLXNA2. Interacts with UBXD5 (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasm, cytoskeleton Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BLR7-1; Sequence=Displayed; Name=2; IsoId=Q8BLR7-2; Sequence=VSP_012768; Name=3; IsoId=Q8BLR7-3; Sequence=VSP_012769; Belongs to the small GTPase superfamily. Rho family. nucleotide binding GTPase activity receptor binding GTP binding cytoplasm cytosol cytoskeleton plasma membrane adherens junction cell cortex actin filament organization negative regulation of cell adhesion small GTPase mediated signal transduction Rho protein signal transduction regulation of cell shape actin cytoskeleton membrane neuron remodeling protein kinase binding regulation of cell migration establishment or maintenance of actin cytoskeleton polarity cell division site regulation of actin cytoskeleton organization intracellular membrane-bounded organelle actin filament bundle assembly uc007xni.1 uc007xni.2 
ENSMUST00000003459.4 Myo1g ENSMUST00000003459.4 myosin IG (from RefSeq NM_178440.4) ENSMUST00000003459.1 ENSMUST00000003459.2 ENSMUST00000003459.3 MYO1G_MOUSE NM_178440 Q5SUA5 Q8BIT8 Q8BJ17 Q8BJ65 Q8R019 Q91ZI1 uc007hyt.1 uc007hyt.2 uc007hyt.3 Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration (PubMed:25083865). Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication (PubMed:25083865). Also required in B- cells, where it regulates different membrane/cytoskeleton-dependent processes (PubMed:24310084). Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis (PubMed:23038771). Interacts with calmodulin; via its IQ motifs. Cell membrane eripheral membrane protein ll projection, phagocytic cup Note=Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup (PubMed:23038771). In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating cells or when membranes are deformed (PubMed:25083865). Specifically expressed in hematopoietic cells. Detected in adult tissues of the immune system such as thymus, lymph nodes and spleen, but not in brain, lung, heart, liver, small intestine, testis and kidney (at protein level). Highly expressed in T- lymphocytes; constitutes the most highly expressed class I myosin in naive CD4 and CD8 T-cells. Also present in B-lymphocytes. The myosin tail domain mediates binding to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) and binds to membranous compartments. It is required for recruitment to Fc-gamma receptor (Fc-gamma-R) phagocytic cups. T-cells display impaired migration patterns and are less efficient in scanning and evaluating antigen-presenting cells. T-cells show global reduction in membrane tension, while their homeostatic tissue distribution and responsiveness to T-cell receptor (TCR) engagement are unaffected. However, T-cells move faster and straighter, leading to defects in detection of antigen-presenting cells, specifically for detection of rare antigens. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. It is uncertain whether Met-1 or Met-7 is the initiator. Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1). Sequence=BAC31139.1; Type=Frameshift; Evidence=; nucleotide binding phagocytic cup adaptive immune response immune system process T cell mediated immunity motor activity actin binding calmodulin binding ATP binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding plasma membrane microvillus exocytosis phagocytosis lipid binding membrane myosin complex lamellipodium filopodium leading edge membrane cell-substrate adhesion Fc-gamma receptor signaling pathway involved in phagocytosis cell projection phosphatidylinositol-3,4-bisphosphate binding cell gliding uc007hyt.1 uc007hyt.2 uc007hyt.3 
ENSMUST00000003461.15 Ogdh ENSMUST00000003461.15 oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide), transcript variant 4 (from RefSeq NM_010956.4) ENSMUST00000003461.1 ENSMUST00000003461.10 ENSMUST00000003461.11 ENSMUST00000003461.12 ENSMUST00000003461.13 ENSMUST00000003461.14 ENSMUST00000003461.2 ENSMUST00000003461.3 ENSMUST00000003461.4 ENSMUST00000003461.5 ENSMUST00000003461.6 ENSMUST00000003461.7 ENSMUST00000003461.8 ENSMUST00000003461.9 Kiaa4192 NM_010956 ODO1_MOUSE Ogdh Q3UDM7 Q5DTI4 Q5SVX7 Q5SVX9 Q60597 Q6PFZ2 Q80Y57 Q8K0K7 Q8K2Z3 Q8R3M2 Q91WP2 uc007hyf.1 uc007hyf.2 uc007hyf.3 uc007hyf.4 2-oxoglutarate dehydrogenase (E1o) component of the 2- oxoglutarate dehydrogenase complex (OGDHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC. Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine- residue succinyltransferase or DLST). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids. Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate. Mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. Reaction=2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl- [dihydrolipoyllysine-residue succinyltransferase] = CO2 + N(6)-[(R)- S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]; Xref=Rhea:RHEA:12188, Rhea:RHEA-COMP:10483, Rhea:RHEA-COMP:10484, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:83099, ChEBI:CHEBI:83120; EC=1.2.4.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12189; Evidence=; Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Calcium ions and ADP stimulate, whereas ATP and NADH reduce catalytic activity. The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2), DLD (dihydrolipoamide dehydrogenase; E3) and the assembly factor KGD4 (PubMed:36854377). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A. Interacts with ABHD11; this interaction maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (By similarity). Mitochondrion Nucleus Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2- oxoglutarate dehydrogenase complex is required for histone succinylation. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q60597-1; Sequence=Displayed; Name=2; IsoId=Q60597-2; Sequence=VSP_024799; Name=3; IsoId=Q60597-3; Sequence=VSP_024801; Name=4; IsoId=Q60597-4; Sequence=VSP_024800; The mitochondrial 2-oxoglutarate and 2-oxoadipate dehydrogenase complexes (OGDHC and OADHC, respectively) share their E2 (DLST) and E3 (dihydrolipoyl dehydrogenase or DLD) components, but the E1 component is specific to each complex (E1o and E1a (DHTK1), respectively). Belongs to the alpha-ketoglutarate dehydrogenase family. Sequence=AAH31165.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD90530.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; oxoglutarate dehydrogenase (succinyl-transferring) activity nucleus mitochondrion mitochondrial matrix generation of precursor metabolites and energy glycolytic process tricarboxylic acid cycle 2-oxoglutarate metabolic process succinyl-CoA metabolic process NADH metabolic process oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor cerebellar cortex development striatum development hippocampus development thalamus development pyramidal neuron development tangential migration from the subventricular zone to the olfactory bulb thiamine pyrophosphate binding heat shock protein binding mitochondrial membrane oxoglutarate dehydrogenase (NAD+) activity oxoglutarate dehydrogenase complex metal ion binding chaperone binding oxidation-reduction process olfactory bulb mitral cell layer development uc007hyf.1 uc007hyf.2 uc007hyf.3 uc007hyf.4 
ENSMUST00000003468.10 Grik5 ENSMUST00000003468.10 glutamate receptor, ionotropic, kainate 5 (gamma 2), transcript variant 1 (from RefSeq NM_008168.3) ENSMUST00000003468.1 ENSMUST00000003468.2 ENSMUST00000003468.3 ENSMUST00000003468.4 ENSMUST00000003468.5 ENSMUST00000003468.6 ENSMUST00000003468.7 ENSMUST00000003468.8 ENSMUST00000003468.9 G5E822 GRIK5_MOUSE NM_008168 Q61626 uc009frh.1 uc009frh.2 uc009frh.3 uc009frh.4 uc009frh.5 Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate = glutamate >> AMPA. Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity (By similarity). Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily. ionotropic glutamate receptor activity ion channel activity protein binding nucleus endoplasmic reticulum plasma membrane protein retention in ER lumen ion transport chemical synaptic transmission glutamate receptor activity ionotropic glutamate receptor complex postsynaptic density ligand-gated ion channel activity kainate selective glutamate receptor activity membrane integral component of membrane SH3 domain binding cell junction PDZ domain binding axon dendrite regulation of synaptic vesicle fusion to presynaptic membrane kainate selective glutamate receptor complex ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic signaling receptor activity regulation of membrane potential presynaptic membrane identical protein binding neuron projection neuronal cell body receptor clustering terminal bouton perikaryon positive regulation of neuron apoptotic process synapse postsynaptic membrane modulation of synaptic transmission establishment of localization in cell excitatory postsynaptic potential cellular response to glucose stimulus postsynaptic density membrane glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane integral component of postsynaptic density membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc009frh.1 uc009frh.2 uc009frh.3 uc009frh.4 uc009frh.5 
ENSMUST00000003469.8 Cd79a ENSMUST00000003469.8 CD79A antigen (immunoglobulin-associated alpha) (from RefSeq NM_007655.4) CD79A_MOUSE ENSMUST00000003469.1 ENSMUST00000003469.2 ENSMUST00000003469.3 ENSMUST00000003469.4 ENSMUST00000003469.5 ENSMUST00000003469.6 ENSMUST00000003469.7 Iga Mb-1 NM_007655 P11911 Q6GTY0 uc009fqt.1 uc009fqt.2 uc009fqt.3 Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B- cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B- cells. Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-204, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity. Cell membrane ingle-pass type I membrane protein Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. B-cells. The transmembrane helices of CD79A and CD79B chains and two IgM heavy chains assembly in a four-helix bundle structure that appears to be conserved among different BCR isotypes. Phosphorylated on tyrosine, serine and threonine residues upon B- cell activation. Phosphorylation of tyrosine residues by Src-family kinases, including LYN, is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation. Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation. Mice display impaired B-cell development which does not progress pass the progenitor stage. adaptive immune response immune system process transmembrane signaling receptor activity protein binding multivesicular body plasma membrane cell surface receptor signaling pathway external side of plasma membrane membrane integral component of membrane B cell receptor complex B cell differentiation B cell proliferation B cell activation protein homodimerization activity membrane raft B cell receptor signaling pathway protein homotetramerization uc009fqt.1 uc009fqt.2 uc009fqt.3 
ENSMUST00000003501.9 Elavl3 ENSMUST00000003501.9 ELAV like RNA binding protein 3 (from RefSeq NM_010487.2) ELAV3_MOUSE ENSMUST00000003501.1 ENSMUST00000003501.2 ENSMUST00000003501.3 ENSMUST00000003501.4 ENSMUST00000003501.5 ENSMUST00000003501.6 ENSMUST00000003501.7 ENSMUST00000003501.8 Huc NM_010487 Q60900 Q60901 uc009onl.1 uc009onl.2 uc009onl.3 uc009onl.4 RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10734193, PubMed:9016658). May also bind poly-A tracts via RRM 3 (PubMed:9016658). May be involved in neuronal differentiation and maintenance (PubMed:9016658). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (PubMed:11573004). Interacts with MAP1B light chain LC1. Event=Alternative splicing; Named isoforms=2; Name=HuC-L; IsoId=Q60900-1; Sequence=Displayed; Name=HuC-S; IsoId=Q60900-2; Sequence=VSP_005790; Brain specific (PubMed:9016658). Expressed in the hippocampus with expression in CA1, CA3 and dentate gyrus (PubMed:11573004). Up-regulated after spatial learning in radial arm maze experiments and in Morris water maze experiments. RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences. RNAi-mediated knockdown results in reduced Gap43 mRNA levels and impaired learning behavior in radial arm maze training. Belongs to the RRM elav family. nucleic acid binding RNA binding multicellular organism development nervous system development cell differentiation mRNA 3'-UTR AU-rich region binding ribonucleoprotein complex uc009onl.1 uc009onl.2 uc009onl.3 uc009onl.4 
ENSMUST00000003509.10 St8sia6 ENSMUST00000003509.10 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 (from RefSeq NM_145838.2) ENSMUST00000003509.1 ENSMUST00000003509.2 ENSMUST00000003509.3 ENSMUST00000003509.4 ENSMUST00000003509.5 ENSMUST00000003509.6 ENSMUST00000003509.7 ENSMUST00000003509.8 ENSMUST00000003509.9 NM_145838 Q8K4T1 SIA8F_MOUSE Siat8f St8sia6 uc008ikc.1 uc008ikc.2 uc008ikc.3 uc008ikc.4 uc008ikc.5 Alpha-2,8-sialyltransferase that prefers O-glycans to N- glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups. Reaction=a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 + CMP + H(+); Xref=Rhea:RHEA:48288, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:79210, ChEBI:CHEBI:79214; Evidence=; Reaction=a ganglioside GM3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41760, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60065, ChEBI:CHEBI:60377, ChEBI:CHEBI:78436; Evidence=; Reaction=a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1a (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41768, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78445, ChEBI:CHEBI:78447; Evidence=; Reaction=a ganglioside GD1a + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1a + CMP + H(+); Xref=Rhea:RHEA:48912, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:82637, ChEBI:CHEBI:90501; Evidence=; Reaction=a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:47576, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568, ChEBI:CHEBI:87787; Evidence=; Reaction=a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c + CMP + H(+); Xref=Rhea:RHEA:48916, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:90151, ChEBI:CHEBI:90856; Evidence=; Reaction=a ganglioside GM4 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl- (2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP + H(+); Xref=Rhea:RHEA:48924, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78482, ChEBI:CHEBI:90858; Evidence=; Reaction=CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl- (2->3)-beta-D-galactosyl-(1<->1')-ceramide = CMP + H(+) + N-acetyl- alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D- galactosyl-(1<->1')-ceramide; Xref=Rhea:RHEA:48928, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:82643, ChEBI:CHEBI:90859; Evidence=; Reaction=a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1b (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41772, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78452, ChEBI:CHEBI:78455; Evidence=; Reaction=a ganglioside GT1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1b + CMP + H(+); Xref=Rhea:RHEA:48932, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:82940, ChEBI:CHEBI:90862; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Highly expressed in kidney and expressed and all tissues tested. Belongs to the glycosyltransferase 29 family. Name=Functional Glycomics Gateway - GTase; Note=ST8Sia VI; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_661"; Golgi membrane ganglioside biosynthetic process blastocyst hatching Golgi apparatus protein glycosylation protein O-linked glycosylation sialyltransferase activity glycoprotein metabolic process glycolipid biosynthetic process oligosaccharide metabolic process membrane integral component of membrane carbohydrate biosynthetic process transferase activity transferase activity, transferring glycosyl groups sialylation uc008ikc.1 uc008ikc.2 uc008ikc.3 uc008ikc.4 uc008ikc.5 
ENSMUST00000003512.9 Fcgrt ENSMUST00000003512.9 Fc fragment of IgG receptor and transporter, transcript variant 1 (from RefSeq NM_010189.3) ENSMUST00000003512.1 ENSMUST00000003512.2 ENSMUST00000003512.3 ENSMUST00000003512.4 ENSMUST00000003512.5 ENSMUST00000003512.6 ENSMUST00000003512.7 ENSMUST00000003512.8 FCGRN_MOUSE Fcrn NM_010189 Q61559 Q9QUR0 Q9R2A5 uc009gtf.1 uc009gtf.2 uc009gtf.3 uc009gtf.4 Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7504013). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB. FcRn complex consists of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer. Interacts with albumin/ALB; this interaction regulates ALB homeostasis. Cell membrane ; Single-pass type I membrane protein Endosome membrane Intestinal epithelium of suckling rodents. Expressed in neonatal intestine and fetal yolk sac. Belongs to the immunoglobulin superfamily. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent extracellular space endosome plasma membrane immune response external side of plasma membrane endosome membrane membrane integral component of membrane IgG binding beta-2-microglobulin binding peptide antigen binding uc009gtf.1 uc009gtf.2 uc009gtf.3 uc009gtf.4 
ENSMUST00000003513.11 Nosip ENSMUST00000003513.11 nitric oxide synthase interacting protein, transcript variant 1 (from RefSeq NM_025533.3) ENSMUST00000003513.1 ENSMUST00000003513.10 ENSMUST00000003513.2 ENSMUST00000003513.3 ENSMUST00000003513.4 ENSMUST00000003513.5 ENSMUST00000003513.6 ENSMUST00000003513.7 ENSMUST00000003513.8 ENSMUST00000003513.9 NM_025533 NOSIP_MOUSE Q9D6T0 Q9D8J9 uc009gsx.1 uc009gsx.2 uc009gsx.3 uc009gsx.4 E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (PubMed:25546391). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with NOS1 and NOS3 (By similarity). Interacts with PP2A holoenzyme, containing PPP2CA, PPP2CB, PPP2R1A and PPP2R2A subunits (PubMed:25546391). Cytoplasm Nucleus Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D6T0-1; Sequence=Displayed; Name=2; IsoId=Q9D6T0-2; Sequence=VSP_023795; The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not. Although mutant embryos are present at the expected Mendelian rate at 18.5 dpc, they die shortly after birth with signs of respiratory distress and cyanosis, likely due to craniofacial malformations. Malformations in knockout mice range from ocular hypotelorism, narrow snout, laterally cleft lip, and cleft secondary palate to cyclopia and presence of proboscis or a single head-like protrusion devoid of facial features. In addition, the weight of knockout embryos is significantly reduced. In knockout animals, PP2A activity is increased in palatal and facial tissues as compared to wild-type, but not in lungs, which do not seem to be affected by the mutation. Belongs to the NOSIP family. nucleus cytoplasm multicellular organism development protein ubiquitination transferase activity negative regulation of catalytic activity negative regulation of nitric-oxide synthase activity ubiquitin protein ligase activity uc009gsx.1 uc009gsx.2 uc009gsx.3 uc009gsx.4 
ENSMUST00000003521.10 Rps11 ENSMUST00000003521.10 ribosomal protein S11 (from RefSeq NM_013725.4) ENSMUST00000003521.1 ENSMUST00000003521.2 ENSMUST00000003521.3 ENSMUST00000003521.4 ENSMUST00000003521.5 ENSMUST00000003521.6 ENSMUST00000003521.7 ENSMUST00000003521.8 ENSMUST00000003521.9 NM_013725 Q3UC02 Q3UC02_MOUSE Rps11 uc009gth.1 uc009gth.2 uc009gth.3 uc009gth.4 Belongs to the universal ribosomal protein uS17 family. structural constituent of ribosome ribosome translation cytosolic small ribosomal subunit uc009gth.1 uc009gth.2 uc009gth.3 uc009gth.4 
ENSMUST00000003527.10 Supt5 ENSMUST00000003527.10 suppressor of Ty 5, DSIF elongation factor subunit, transcript variant 1 (from RefSeq NM_013676.2) ENSMUST00000003527.1 ENSMUST00000003527.2 ENSMUST00000003527.3 ENSMUST00000003527.4 ENSMUST00000003527.5 ENSMUST00000003527.6 ENSMUST00000003527.7 ENSMUST00000003527.8 ENSMUST00000003527.9 NM_013676 O55201 Q3UJ77 Q3UJH1 Q3UKD7 Q3UM54 Q6PB73 Q6PDP0 Q6PFR4 SPT5H_MOUSE Supt5h uc009fyj.1 uc009fyj.2 uc009fyj.3 Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity). Interacts with SUPT4H1 to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of NELFA, NELFB, NELFD and NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. Also interacts with PRMT1/HRMT1L2, HTATSF1/TATSF1, RNGTT/CAP1A, PRMT5/SKB1, SUPT6H, and can interact with PIN1. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin (By similarity). Interacts with MCM3AP (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O55201-1; Sequence=Displayed; Name=2; IsoId=O55201-2; Sequence=VSP_016283; Methylated by PRMT1/HRMT1L2 and PRMT5/SKB1. Methylation negatively regulates interaction with P-TEFb and RNA polymerase II (By similarity). Phosphorylated by CDK7 and CDK9. Phosphorylation by P-TEFb alleviates transcriptional pausing. Phosphorylation may also stimulate interaction with PIN1. Bulk phosphorylation occurs predominantly in mitosis (By similarity). Belongs to the SPT5 family. Sequence=AAH57449.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter chromatin binding mRNA binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter positive regulation of macroautophagy enzyme binding DSIF complex regulation of DNA-templated transcription, elongation negative regulation of DNA-templated transcription, elongation positive regulation of DNA-templated transcription, elongation positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity negative regulation of mRNA polyadenylation uc009fyj.1 uc009fyj.2 uc009fyj.3 
ENSMUST00000003529.9 Paf1 ENSMUST00000003529.9 Paf1, RNA polymerase II complex component (from RefSeq NM_019458.3) ENSMUST00000003529.1 ENSMUST00000003529.2 ENSMUST00000003529.3 ENSMUST00000003529.4 ENSMUST00000003529.5 ENSMUST00000003529.6 ENSMUST00000003529.7 ENSMUST00000003529.8 NM_019458 PAF1_MOUSE Q3UY97 Q8K2T8 Q9CS63 Q9JJ99 uc009fyu.1 uc009fyu.2 uc009fyu.3 Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors (By similarity). Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and SKIC8. The PAF1 complex interacts with PHF5A (PubMed:27749823). Interacts with POLR2A, TCEA1, SKIC3, KMT2A/MLL1, SUPT5H, RNF20 and RNF40. Interacts with UBE2E1 (By similarity). Nucleus. Note=Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin. Belongs to the PAF1 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core binding endodermal cell fate commitment chromatin binding protein binding nucleus nucleoplasm cytoplasm transcription elongation from RNA polymerase II promoter mRNA polyadenylation histone monoubiquitination membrane Wnt signaling pathway histone modification nucleosome positioning Cdc73/Paf1 complex stem cell population maintenance cell junction positive regulation of histone methylation positive regulation of mRNA 3'-end processing positive regulation of transcription elongation from RNA polymerase II promoter histone H2B ubiquitination protein localization to nucleus transcriptionally active chromatin negative regulation of myeloid cell differentiation positive regulation of transcription from RNA polymerase II promoter cellular response to lipopolysaccharide positive regulation of cell cycle G1/S phase transition uc009fyu.1 uc009fyu.2 uc009fyu.3 
ENSMUST00000003536.9 Med29 ENSMUST00000003536.9 mediator complex subunit 29 (from RefSeq NM_026042.4) ENSMUST00000003536.1 ENSMUST00000003536.2 ENSMUST00000003536.3 ENSMUST00000003536.4 ENSMUST00000003536.5 ENSMUST00000003536.6 ENSMUST00000003536.7 ENSMUST00000003536.8 Ixl MED29_MOUSE NM_026042 Q9DB91 uc009fyt.1 uc009fyt.2 uc009fyt.3 uc009fyt.4 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Associates with the MED18/MED20 heteromer (By similarity). Nucleus Belongs to the Mediator complex subunit 29 family. molecular_function nucleus nucleoplasm biological_process mediator complex uc009fyt.1 uc009fyt.2 uc009fyt.3 uc009fyt.4 
ENSMUST00000003550.11 Ncstn ENSMUST00000003550.11 nicastrin (from RefSeq NM_021607.3) E9QLZ6 ENSMUST00000003550.1 ENSMUST00000003550.10 ENSMUST00000003550.2 ENSMUST00000003550.3 ENSMUST00000003550.4 ENSMUST00000003550.5 ENSMUST00000003550.6 ENSMUST00000003550.7 ENSMUST00000003550.8 ENSMUST00000003550.9 NICA_MOUSE NM_021607 P57716 Q8VE20 uc007dpk.1 uc007dpk.2 uc007dpk.3 uc007dpk.4 Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Component of the gamma-secretase complex. The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2 (PubMed:12716934). Binds to proteolytic processed C- terminal fragments C83 and C99 of the amyloid precursor protein (APP). Interacts with PSEN1 and PSEN2. P57716; P14211: Calr; NbExp=2; IntAct=EBI-998934, EBI-644340; P57716; Q9DBY1: Syvn1; NbExp=2; IntAct=EBI-998934, EBI-644384; Membrane ; Single- pass type I membrane protein Cytoplasmic vesicle membrane ; Single- pass type I membrane protein Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. N-glycosylated. Full embryonic lethality. No embryos survive past 10.d dpc. At 9.5 dpc the embryos display a phenotype similar to that of Notch1-deficient mice, with defects in the development of the caudal part of the embryo and in somite segementation, defective vascular morphogenesis in the yolk sac, and patterning defects in the developing heart and neural tube. Assembly of the gamma-secretase complex and APP processing are disrupted. Belongs to the nicastrin family. myeloid cell homeostasis protein binding cytoplasm mitochondrion lysosome lysosomal membrane early endosome endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane membrane protein ectodomain proteolysis dopamine receptor signaling pathway glutamate receptor signaling pathway Notch signaling pathway Notch receptor processing learning or memory synaptic vesicle peptidase activity membrane integral component of membrane protein processing cerebellum development central nervous system myelination adult behavior cytoplasmic vesicle membrane cytoplasmic vesicle macromolecular complex beta-amyloid formation T cell proliferation sarcolemma melanosome amyloid precursor protein metabolic process amyloid precursor protein biosynthetic process positive regulation of amyloid precursor protein biosynthetic process positive regulation of catalytic activity synapse beta-amyloid metabolic process epithelial cell proliferation neuron apoptotic process gamma-secretase complex neuron death cellular response to calcium ion synaptic membrane integral component of presynaptic membrane regulation of long-term synaptic potentiation short-term synaptic potentiation endopeptidase activity uc007dpk.1 uc007dpk.2 uc007dpk.3 uc007dpk.4 
ENSMUST00000003554.11 Casq1 ENSMUST00000003554.11 calsequestrin 1 (from RefSeq NM_009813.2) CASQ1_MOUSE ENSMUST00000003554.1 ENSMUST00000003554.10 ENSMUST00000003554.2 ENSMUST00000003554.3 ENSMUST00000003554.4 ENSMUST00000003554.5 ENSMUST00000003554.6 ENSMUST00000003554.7 ENSMUST00000003554.8 ENSMUST00000003554.9 NM_009813 O09165 uc007dqa.1 uc007dqa.2 uc007dqa.3 uc007dqa.4 Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions (By similarity). Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). Monomer; increases in response to a depletion of intracellular calcium. Homodimer. Homotetramer and homopolymer. Can form linear homooligomers. Ca(2+) ions promote oligomerization. Interacts (via C- terminal end and preferentially with the monomeric form) with STIM1; this interaction increases in response to a depletion of intracellular calcium, decreases both STIM1 aggregation and clustering, interaction of STIM1 with ORAI1 and store-operated Ca(2+) entry (SOCE) activity. Interacts with ASPH and TRDN. Endoplasmic reticulum Sarcoplasmic reticulum Sarcoplasmic reticulum lumen Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side Mitochondrion matrix Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells (PubMed:22049211). Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells. In a minority of cells, homogeneously detected in the ER lumen. Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellular calcium (By similarity). Detected in skeletal muscle (at protein level). Detected in skeletal muscle. N-glycosylated. Mice are viable and fertile, but have a lower body weight than wild-type, due to a reduction in fast-twitch muscle mass. Fast-twitch muscle from mutant mice exhibits slower contraction kinetics and requires more time to achieve peak tension and to achieve half-relaxation after a contraction. Fast-twitch muscle fibers from mutant mice show a strikingly altered structure of the calcium release units in the sarcoplasmic reticulum with a strongly increased number of ryanodine receptors, plus narrower sarcoplasmic reticulum cisternae. In addition, the number of mitochondria is increased in mutant muscle. Mutant muscle fibers show smaller calcium transients upon electrical stimulation and release less Ca(2+) in response to caffeine. Belongs to the calsequestrin family. Sequence=AAC63616.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; calcium ion binding cytoplasm mitochondrion mitochondrial matrix endoplasmic reticulum Golgi apparatus regulation of muscle contraction endoplasmic reticulum organization skeletal muscle tissue development response to heat response to organic substance regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum terminal cisterna terminal cisterna lumen regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion response to muscle inactivity response to denervation involved in regulation of muscle adaptation membrane sarcoplasmic reticulum myofibril Z disc T-tubule I band sarcoplasmic reticulum membrane sarcoplasmic reticulum lumen sarcolemma identical protein binding intracellular membrane-bounded organelle sarcomere organization metal ion binding protein polymerization positive regulation of release of sequestered calcium ion into cytosol regulation of sequestering of calcium ion positive regulation of store-operated calcium channel activity regulation of store-operated calcium entry uc007dqa.1 uc007dqa.2 uc007dqa.3 uc007dqa.4 
ENSMUST00000003561.10 Phyhip ENSMUST00000003561.10 phytanoyl-CoA hydroxylase interacting protein (from RefSeq NM_145981.3) ENSMUST00000003561.1 ENSMUST00000003561.2 ENSMUST00000003561.3 ENSMUST00000003561.4 ENSMUST00000003561.5 ENSMUST00000003561.6 ENSMUST00000003561.7 ENSMUST00000003561.8 ENSMUST00000003561.9 NM_145981 PHYIP_MOUSE Q8K0S0 uc007uoa.1 uc007uoa.2 uc007uoa.3 Its interaction with PHYH suggests a role in the development of the central system. Interacts with PHYH and ADGRB1. Highly expressed in the brain. At 18 dpc, expressed in most tissues, particularly in the skin. By neonatal day 1, the expression in brain and skin is markedly increased, whereas expression in the heart and skeletal muscles shows steady state levels similar to those observed in the fetus. At adulthood, very high expression in brain, little or no expression in other tissues. Overexpression in heart induce atrial tachycardia and increased susceptibility to aconitine-induced arrhythmia, possibly due to altered expression of voltage-gated K(1+) channel and adrenergic beta1-receptor (ADRB1). Belongs to the PHYHIP family. Sequence=AAH30494.2; Type=Erroneous initiation; Evidence=; protein binding cytoplasm protein localization protein tyrosine kinase binding uc007uoa.1 uc007uoa.2 uc007uoa.3 
ENSMUST00000003569.6 Inmt ENSMUST00000003569.6 indolethylamine N-methyltransferase (from RefSeq NM_009349.3) ENSMUST00000003569.1 ENSMUST00000003569.2 ENSMUST00000003569.3 ENSMUST00000003569.4 ENSMUST00000003569.5 INMT_MOUSE NM_009349 P40936 Q9CZ50 Temt uc009can.1 uc009can.2 uc009can.3 Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as a thioether S- methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3- methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2- methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds. Reaction=a tertiary amine + S-adenosyl-L-methionine = a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:53928, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:137982, ChEBI:CHEBI:137983; EC=2.1.1.49; Evidence=; Reaction=a secondary amine + S-adenosyl-L-methionine = a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:53924, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:137419, ChEBI:CHEBI:137984; EC=2.1.1.49; Evidence=; Reaction=a primary amine + S-adenosyl-L-methionine = a methylated primary amine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:23136, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65296, ChEBI:CHEBI:131823; EC=2.1.1.49; Evidence=; Reaction=dimethyl sulfide + S-adenosyl-L-methionine = S-adenosyl-L- homocysteine + trimethylsulfonium; Xref=Rhea:RHEA:19613, ChEBI:CHEBI:17434, ChEBI:CHEBI:17437, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.96; Evidence=; Inhibited by the S-adenosyl-L-methionine analog sinefungin and by the product S-adenosyl-L-homocysteine. Kinetic parameters: KM=0.4 uM for dimethyl selenide; KM=1.0 uM for dimethyl sulfide; KM=1.0 uM for S-adenosyl-L-methionine; pH dependence: Optimum pH is 6.3.; Monomer. Cytoplasm Detected in lung and liver (at protein level). Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. Was originally thought to be a thioether S-methyltransferase but appears to be the ortholog of human INMT. thioether S-methyltransferase activity cytoplasm cytosol methyltransferase activity amine metabolic process response to toxic substance transferase activity amine N-methyltransferase activity methylation dimethyl selenide methyltransferase activity uc009can.1 uc009can.2 uc009can.3 
ENSMUST00000003572.10 Gars1 ENSMUST00000003572.10 glycyl-tRNA synthetase 1 (from RefSeq NM_180678.3) ENSMUST00000003572.1 ENSMUST00000003572.2 ENSMUST00000003572.3 ENSMUST00000003572.4 ENSMUST00000003572.5 ENSMUST00000003572.6 ENSMUST00000003572.7 ENSMUST00000003572.8 ENSMUST00000003572.9 GARS_MOUSE Gars NM_180678 Q3TMM4 Q3UK01 Q8VC67 Q9CZD3 uc009cai.1 uc009cai.2 uc009cai.3 Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. Reaction=ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl- tRNA(Gly); Xref=Rhea:RHEA:16013, Rhea:RHEA-COMP:9664, Rhea:RHEA- COMP:9683, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57305, ChEBI:CHEBI:78442, ChEBI:CHEBI:78522, ChEBI:CHEBI:456215; EC=6.1.1.14; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16014; Evidence=; Reaction=2 ATP + H(+) = diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate; Xref=Rhea:RHEA:34935, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58141; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:34936; Evidence=; Homodimer. Q9CZD3; P41250: GARS1; Xeno; NbExp=2; IntAct=EBI-8321941, EBI-724143; Cytoplasm Mitochondrion Cell projection, axon Secreted Secreted, extracellular exosome Note=Associated with granules in cultured neuron cells (By similarity). Secreted by motor neuron and differentiated myotube cell lines, but not by undifferentiated myoblasts, possibly through the exosome pathway (PubMed:26503042). Note=Mice (Nmf249) heterozygous for the P278YK variant are used a model for human Charcot-Marie-Tooth 2D (CMT2D), which is caused by dominant GARS mutations. They exhibit reduced amplitudes of muscle compound action potentials and a large reduction in sciatic nerve conduction velocity in the absence of demyelination or remyelination, resulting from an age-related decrease in the number of large myelinated motor and sensory axons. The loss of myelinated axons is length-dependent, and there is a length- and time-dependent decrease in motor innervation of distal versus proximal muscles. Most of the axonal loss occurs by 1 month of age and mice that survive this period can be long-lived. At the molecular level, the P278YK mutation creates a neomorphic binding activity leading to the interaction of the variant with NRP1. This interaction competes out VEGFA binding and inhibits VEGFA-NRP1 signling which is essential for motor neuron survival. VEGFA, but not GDNF treatment significantly ameliorates the loss of motor function in mutant mice. Belongs to the class-II aminoacyl-tRNA synthetase family. nucleotide binding bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity aminoacyl-tRNA ligase activity glycine-tRNA ligase activity protein binding ATP binding extracellular region cytoplasm mitochondrion cytosol translation tRNA aminoacylation for protein translation glycyl-tRNA aminoacylation diadenosine tetraphosphate biosynthetic process transferase activity hydrolase activity ligase activity secretory granule axon identical protein binding cell projection protein dimerization activity extracellular exosome mitochondrial glycyl-tRNA aminoacylation uc009cai.1 uc009cai.2 uc009cai.3 
ENSMUST00000003574.5 Cyp4f18 ENSMUST00000003574.5 cytochrome P450, family 4, subfamily f, polypeptide 18 (from RefSeq NM_024444.2) CP4F3_MOUSE Cyp4f18 Cyp4f3 E9QLZ3 ENSMUST00000003574.1 ENSMUST00000003574.2 ENSMUST00000003574.3 ENSMUST00000003574.4 NM_024444 Q99N16 Q9D8N4 uc009mfe.1 uc009mfe.2 uc009mfe.3 A cytochrome P450 monooxygenase involved in the metabolism of the pro-inflammatory lipid mediator leukotriene B4 (LTB4) (PubMed:16380383, PubMed:24632148). Hydroxylates at the omega-1 and omega-2 positions LTB4. This oxidation step leads to LTB4 inactivation, which is postulated to be a crucial part of the resolution of inflammation (PubMed:16380383, PubMed:24632148). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:16380383, PubMed:24632148). Reaction=leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53440, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57461, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:137391; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53441; Evidence=; Reaction=leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53436, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57461, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:137390; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53437; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Lipid metabolism; leukotriene B4 degradation. Endoplasmic reticulum membrane ; Single-pass membrane protein Microsome membrane ; Single-pass membrane protein Highest level in polymorphonuclear leukocytes and dendritic cells. Detectable in lymph nodes, spleen, bone marrow and peripheral blood. Highly expressed in ovary. Very low level in liver, kidney, and smooth muscle. Expressed in neutrophils (at protein level). Up-regulated in bone marrow-derived dendritic cells by bacterial lipopolysaccharide (LPS), a ligand for toll-like receptor 4 (TLR4), and by poly(I:C), a ligand for TLR3. Mice are born at the expected Mendelian rate. No visible phenotype. Belongs to the cytochrome P450 family. very long-chain fatty acid metabolic process long-chain fatty acid metabolic process monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process regulation of blood pressure arachidonic acid epoxygenase activity membrane integral component of membrane apical plasma membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen drug metabolic process alkane 1-monooxygenase activity arachidonic acid metabolic process epoxygenase P450 pathway heme binding organelle membrane negative regulation of icosanoid secretion positive regulation of icosanoid secretion leukotriene B4 catabolic process vitamin E metabolic process menaquinone catabolic process phylloquinone catabolic process vitamin K catabolic process intracellular membrane-bounded organelle metal ion binding leukotriene-B4 20-monooxygenase activity arachidonic acid omega-hydroxylase activity alpha-tocopherol omega-hydroxylase activity tocotrienol omega-hydroxylase activity oxidation-reduction process uc009mfe.1 uc009mfe.2 uc009mfe.3 
ENSMUST00000003575.11 Tpm4 ENSMUST00000003575.11 tropomyosin 4 (from RefSeq NM_001001491.2) ENSMUST00000003575.1 ENSMUST00000003575.10 ENSMUST00000003575.2 ENSMUST00000003575.3 ENSMUST00000003575.4 ENSMUST00000003575.5 ENSMUST00000003575.6 ENSMUST00000003575.7 ENSMUST00000003575.8 ENSMUST00000003575.9 NM_001001491 Q6IRU2 TPM4_MOUSE uc009mfi.1 uc009mfi.2 uc009mfi.3 uc009mfi.4 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain. Cytoplasm, cytoskeleton Note=Associates with F-actin stress fibers. The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity. Belongs to the tropomyosin family. stress fiber podosome actin binding cytoplasm cytoskeleton actin filament actin filament organization actin cytoskeleton cortical cytoskeleton identical protein binding protein homodimerization activity metal ion binding protein heterodimerization activity actin filament binding uc009mfi.1 uc009mfi.2 uc009mfi.3 uc009mfi.4 
ENSMUST00000003597.15 Psg18 ENSMUST00000003597.15 pregnancy specific beta-1-glycoprotein 18, transcript variant 1 (from RefSeq NM_011963.2) B2RSG7 B2RSG7_MOUSE ENSMUST00000003597.1 ENSMUST00000003597.10 ENSMUST00000003597.11 ENSMUST00000003597.12 ENSMUST00000003597.13 ENSMUST00000003597.14 ENSMUST00000003597.2 ENSMUST00000003597.3 ENSMUST00000003597.4 ENSMUST00000003597.5 ENSMUST00000003597.6 ENSMUST00000003597.7 ENSMUST00000003597.8 ENSMUST00000003597.9 NM_011963 Psg18 uc009fji.1 uc009fji.2 uc009fji.3 uc009fji.4 cytokinin biosynthetic process positive regulation of gene expression regulation of interleukin-10 secretion uc009fji.1 uc009fji.2 uc009fji.3 uc009fji.4 
ENSMUST00000003599.9 Pcdhgb6 ENSMUST00000003599.9 protocadherin gamma subfamily B, 6 (from RefSeq NM_033578.3) ENSMUST00000003599.1 ENSMUST00000003599.2 ENSMUST00000003599.3 ENSMUST00000003599.4 ENSMUST00000003599.5 ENSMUST00000003599.6 ENSMUST00000003599.7 ENSMUST00000003599.8 NM_033578 Pcdhgb6 Q91XX4 Q91XX4_MOUSE uc008eqy.1 uc008eqy.2 uc008eqy.3 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules biological_process membrane integral component of membrane uc008eqy.1 uc008eqy.2 uc008eqy.3 
ENSMUST00000003620.13 Prodh ENSMUST00000003620.13 proline dehydrogenase, transcript variant 2 (from RefSeq NR_189733.1) A0JLW6 ENSMUST00000003620.1 ENSMUST00000003620.10 ENSMUST00000003620.11 ENSMUST00000003620.12 ENSMUST00000003620.2 ENSMUST00000003620.3 ENSMUST00000003620.4 ENSMUST00000003620.5 ENSMUST00000003620.6 ENSMUST00000003620.7 ENSMUST00000003620.8 ENSMUST00000003620.9 NR_189733 PROD_MOUSE Pro1 Q3UNR4 Q9QX61 Q9WU79 uc007ymu.1 uc007ymu.2 uc007ymu.3 Converts proline to delta-1-pyrroline-5-carboxylate. Reaction=a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+); Xref=Rhea:RHEA:23784, ChEBI:CHEBI:15378, ChEBI:CHEBI:17388, ChEBI:CHEBI:24646, ChEBI:CHEBI:60039, ChEBI:CHEBI:132124; EC=1.5.5.2; Name=FAD; Xref=ChEBI:CHEBI:57692; Amino-acid degradation; L-proline degradation into L- glutamate; L-glutamate from L-proline: step 1/2. Mitochondrion matrix. Expressed in liver, kidney, heart and to a lesser extent in brain, lung and muscle. Note=Pro/re mice that have a premature termination on Prodh are sluggish in their movement. Belongs to the proline oxidase family. Sequence=AAD24776.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI25328.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=EDK97501.1; Type=Erroneous gene model prediction; Evidence=; proline dehydrogenase activity mitochondrion mitochondrial inner membrane mitochondrial matrix proline metabolic process proline catabolic process proline catabolic process to glutamate oxidoreductase activity amino acid binding oxidation-reduction process FAD binding uc007ymu.1 uc007ymu.2 uc007ymu.3 
ENSMUST00000003621.10 Ess2 ENSMUST00000003621.10 ess-2 splicing factor, transcript variant 1 (from RefSeq NM_022408.2) Dgcr14 ENSMUST00000003621.1 ENSMUST00000003621.2 ENSMUST00000003621.3 ENSMUST00000003621.4 ENSMUST00000003621.5 ENSMUST00000003621.6 ENSMUST00000003621.7 ENSMUST00000003621.8 ENSMUST00000003621.9 Es2el Ess2 NM_022408 Q3UFM6 Q3UFM6_MOUSE uc007ymm.1 uc007ymm.2 The human ortholog of this gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of human chromosome band 22q11.2. The encoded protein localizes to the nucleus, and the orthologous protein in humans co-purifies with C complex spliceosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Nucleus Belongs to the ESS2 family. catalytic step 2 spliceosome uc007ymm.1 uc007ymm.2 
ENSMUST00000003622.16 Slc25a1 ENSMUST00000003622.16 solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 (from RefSeq NM_153150.2) ENSMUST00000003622.1 ENSMUST00000003622.10 ENSMUST00000003622.11 ENSMUST00000003622.12 ENSMUST00000003622.13 ENSMUST00000003622.14 ENSMUST00000003622.15 ENSMUST00000003622.2 ENSMUST00000003622.3 ENSMUST00000003622.4 ENSMUST00000003622.5 ENSMUST00000003622.6 ENSMUST00000003622.7 ENSMUST00000003622.8 ENSMUST00000003622.9 NM_153150 Q3TDH6 Q8JZU2 Slc25a1 TXTP_MOUSE uc007ymp.1 uc007ymp.2 uc007ymp.3 uc007ymp.4 Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extend cis- aconitate, maleate and succinate. In the cytoplasm citrate is important in the regulation of glycolysis through a feedback mechanism and in the production of acetyl-CoA which is needed for the synthesis of fatty acids, sterols, prostaglandins, dolichol and coenzyme Q (CoQ). Required for proper neuromuscular junction formation. Reaction=(S)-malate(in) + citrate(out) = (S)-malate(out) + citrate(in); Xref=Rhea:RHEA:72483, ChEBI:CHEBI:15589, ChEBI:CHEBI:16947; Evidence=; Reaction=citrate(out) + D-threo-isocitrate(in) = citrate(in) + D-threo- isocitrate(out); Xref=Rhea:RHEA:72471, ChEBI:CHEBI:15562, ChEBI:CHEBI:16947; Evidence=; Reaction=citrate(out) + succinate(in) = citrate(in) + succinate(out); Xref=Rhea:RHEA:28835, ChEBI:CHEBI:16947, ChEBI:CHEBI:30031; Evidence=; Reaction=cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in); Xref=Rhea:RHEA:72475, ChEBI:CHEBI:16383, ChEBI:CHEBI:16947; Evidence=; Reaction=citrate(out) + trans-aconitate(in) = citrate(in) + trans- aconitate(out); Xref=Rhea:RHEA:72479, ChEBI:CHEBI:15708, ChEBI:CHEBI:16947; Evidence=; Reaction=citrate(out) + phosphoenolpyruvate(in) = citrate(in) + phosphoenolpyruvate(out); Xref=Rhea:RHEA:72487, ChEBI:CHEBI:16947, ChEBI:CHEBI:58702; Evidence=; Reaction=citrate(out) + maleate(in) = citrate(in) + maleate(out); Xref=Rhea:RHEA:72491, ChEBI:CHEBI:16947, ChEBI:CHEBI:30780; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Expressed minimally but ubiquitously throughout the adult brain. Detected at higher levels in the olfactory bulb, neocortex and cerebellum. Also expressed in a subset of large cells in the globus pallidus. Expression reaches a maximum between 16 dpc and P0 and then declines in adulthood. Possesses a short cleavable presequence, which, however, is found to be dispensable both for targeting to mitochondria and insertion into the inner membrane. However, the presequence is required to keep SLC25A1 in a soluble state and thus in an import-competent state. Mature SLC25A1 lacking the presequence is prone to aggregation. Belongs to the mitochondrial carrier (TC 2.A.29) family. mitochondrion mitochondrial inner membrane mitochondrial citrate transport membrane integral component of membrane transmembrane transporter activity transmembrane transport citrate secondary active transmembrane transporter activity uc007ymp.1 uc007ymp.2 uc007ymp.3 uc007ymp.4 
ENSMUST00000003635.7 Ier3 ENSMUST00000003635.7 immediate early response 3 (from RefSeq NM_133662.2) ENSMUST00000003635.1 ENSMUST00000003635.2 ENSMUST00000003635.3 ENSMUST00000003635.4 ENSMUST00000003635.5 ENSMUST00000003635.6 Gly96 IEX1_MOUSE Iex1 NM_133662 P46694 Q4FJY1 Q91VZ5 uc008cio.1 uc008cio.2 uc008cio.3 May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias. Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation. Membrane ; Single-pass type II membrane protein Expressed predominantly in the lung, testes and the uterus. By serum growth factors and TPA. Glycosylated. Belongs to the IER3 family. response to protozoan negative regulation of systemic arterial blood pressure nucleus mitochondrion regulation of DNA repair mitotic G2 DNA damage checkpoint intrinsic apoptotic signaling pathway in response to DNA damage membrane integral component of membrane negative regulation of apoptotic process positive regulation of protein catabolic process negative regulation of glycolytic process regulation of nucleocytoplasmic transport negative regulation of inflammatory response negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of reactive oxygen species metabolic process regulation of response to DNA damage stimulus uc008cio.1 uc008cio.2 uc008cio.3 
ENSMUST00000003640.4 Fosb ENSMUST00000003640.4 FBJ osteosarcoma oncogene B, transcript variant 1 (from RefSeq NM_008036.2) A0A140LIE4 ENSMUST00000003640.1 ENSMUST00000003640.2 ENSMUST00000003640.3 FOSB_MOUSE Fosb NM_008036 P13346 uc009flk.1 uc009flk.2 uc009flk.3 Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'- TGA[GC]TCA-3' and enhancing their transcriptional activity (PubMed:2498083, PubMed:1900040). As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (PubMed:29272704). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Exhibits transactivation activity in vitro (PubMed:17241283). Involved in the display of nurturing behavior towards newborns (PubMed:8706134). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (PubMed:23303048, PubMed:30902680). Implicated in behavioral responses related to morphine reward and spatial memory (PubMed:9294222, PubMed:18407360). [Isoform 2]: Exhibits lower transactivation activity than isoform 1 in vitro (PubMed:17241283). The heterodimer with JUN does not display any transcriptional activity, and may thereby act as an transcriptional inhibitor (PubMed:1900040). May be involved in the regulation of neurogenesis in the hippocampus (PubMed:23303048). May play a role in synaptic modifications in nucleus accumbens medium spiny neurons and thereby play a role in adaptive and pathological reward- dependent learning, including maladaptive responses involved in drug addiction (PubMed:23319622). Seems to be more stably expressed with a half-life of ~9.5 hours in cell culture as compared to 1.5 hours half- life of isoform 1 (PubMed:18407360). Heterodimer; binds to DNA as heterodimer (PubMed:2498083, PubMed:1900040). Component of an AP-1 transcription factor complex; composed of FOS-JUN heterodimers (PubMed:2498083, PubMed:1900040). As part of the AP-1 transcription factor complex, forms heterodimers with JUN, JUNB or JUND, thereby binding to the AP-1 consensus sequence and stimulating transcription (PubMed:2498083, PubMed:1900040). Interacts with the BAF multiprotein chromatin-remodeling complex subunits SMARCB1 and SMARCD1 (PubMed:29272704). Interacts with ARID1A and JUN (PubMed:29272704). [Isoform 2]: Homodimer under oxidizing conditions and monomer under reducing conditions (in vitro) (By similarity). Heterodimer; binds to DNA as heterodimer (PubMed:1900040). Forms heterodimers with JUNB, JUN or JUND; thereby binding to the AP-1 consensus sequence but does not stimulate transcription (PubMed:1900040). Forms heterodimers with JUND under oxidizing conditions (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P13346-1; Sequence=Displayed; Name=2; Synonyms=deltaFosB , FosB2 , FosB[short form] ; IsoId=P13346-2; Sequence=VSP_061375; Expressed in brain, including the preoptic area of the hypothalamus, the main and accessory olfactory bulbs, the pyriform cortex and the hippocampus (at protein level) (PubMed:8706134, PubMed:23303048). Expressed in the neurons of the subgranular zone of the dentate gyrus in the hippocampus (at protein level) (PubMed:23303048, PubMed:30902680). Expressed in pyramidal cells in CA1 and CA3, in the dentate gyrus and the nucleus accumbens of the striatum (at protein level) (PubMed:9294222, PubMed:26446228). [Isoform 2]: Expressed in the core and shell of the nucleus accumbens of the striatum (at protein level) (PubMed:20473292). Expressed in the neurons of the subgranular zone of the dentate gyrus in the hippocampus (at protein level) (PubMed:23303048). Induced by growth factors (PubMed:2498083). Up-regulated in the preoptic area of the hypothalamus after 6 hours of exposure to pups (PubMed:8706134). Induced by cocaine in the striatum (PubMed:9294222). Induced by kainic acid (PubMed:23303048). Induced in the hippocampus by novelty exposure and spatial learning (PubMed:26446228). [Isoform 1]: Induced by cocaine in the striatum. [Isoform 2]: Induced by cocaine in the striatum (PubMed:9294222). Induced by chronic social defeat stress, with resilient mice showing the greatest induction in both core and shell nucleus accumbens subregions (PubMed:20473292). Binds DNA via bZIP domain; DNA-binding is under control of cellular redox homeostasis (in vitro) (By similarity). To enable DNA binding, the bZIP domain must undergo a conformational rearrangement which requires the reduction of the interchain disulfide bond between FosB and JunD (in vitro) (By similarity). The bZIP domain is able to form homomeric oligomers via formation of interchain disulfide bonds under non-reducing conditions (in vitro) (By similarity). Under reducing conditions, the disulfide-bonded homomeric species dissociates into monomers (in vitro) (By similarity). Phosphorylated. [Isoform 2]: Phosphorylated at Ser-27 by CSNK2A1; phosphorylation increases protein stability and transactivation potential. Deficiency in the ability to nurture young animals and the majority of pups die within 1-2 days of birth (PubMed:8706134). Impaired nurturing behavior towards newborns is observed in postpartum mothers as well as in young females and males (PubMed:8706134). Failure in AP-1 binding activity after repeated cocaine administration (PubMed:9294222). Exaggerated locomotor activation in response to initial cocaine exposures as well as robust conditioned place preference to a lower dose of cocaine, but lack of increment in cocaine-induced hyperactivity over 6 days (i.e. sensitization) (PubMed:9294222). Decreased sensitivity to rewarding properties of morphine and spatial memory impairment (PubMed:18407360). Decreased proliferation and increased ectopic migration of neural progenitor cells in the hippocampus (PubMed:23303048). Exhibit impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior (PubMed:23303048). Altered gene expression in the hippocampus, including genes implicated in neurogenesis, depression, or epilepsy (PubMed:23303048). Knockout in hippocampal neurons, including neurons of the subgranular zone of the dentate gyrus, leads to a reduction of antidepressant-induced neurogenesis and impedes hippocampus-dependent learning in the novel object recognition task (PubMed:30902680). Belongs to the bZIP family. Fos subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter female pregnancy response to mechanical stimulus response to progesterone cellular response to hormone stimulus response to drug intracellular membrane-bounded organelle response to morphine sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter response to corticosterone response to cAMP cellular response to calcium ion uc009flk.1 uc009flk.2 uc009flk.3 
ENSMUST00000003645.9 Ercc1 ENSMUST00000003645.9 excision repair cross-complementing rodent repair deficiency, complementation group 1, transcript variant 5 (from RefSeq NR_178193.1) ENSMUST00000003645.1 ENSMUST00000003645.2 ENSMUST00000003645.3 ENSMUST00000003645.4 ENSMUST00000003645.5 ENSMUST00000003645.6 ENSMUST00000003645.7 ENSMUST00000003645.8 ERCC1_MOUSE Ercc-1 NR_178193 P07903 Q91VP3 uc009flm.1 uc009flm.2 uc009flm.3 uc009flm.4 Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). Heterodimer composed of ERCC1 and ERRC4/XPF (By similarity). Interacts with USP4 (By similarity). Nucleus Ubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Deubiquitinated by USP45. Belongs to the ERCC1/RAD10/SWI10 family. single-stranded DNA endodeoxyribonuclease activity nucleotide-excision repair complex nucleotide-excision repair factor 1 complex meiotic mismatch repair pyrimidine dimer repair by nucleotide-excision repair nuclear chromosome, telomeric region TFIID-class transcription factor binding replicative cell aging DNA binding damaged DNA binding single-stranded DNA binding nuclease activity endonuclease activity protein binding nucleus nucleoplasm transcription factor TFIID complex cytosol DNA repair nucleotide-excision repair nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion double-strand break repair double-strand break repair via nonhomologous end joining DNA recombination mitotic recombination syncytium formation cellular response to DNA damage stimulus response to oxidative stress germ cell development spermatogenesis response to nutrient protein C-terminus binding cell proliferation male gonad development UV protection response to sucrose response to X-ray multicellular organism aging hydrolase activity protein domain specific binding negative regulation of telomere maintenance post-embryonic hemopoiesis multicellular organism growth response to immobilization stress interstrand cross-link repair isotype switching response to cadmium ion cell development oogenesis embryonic organ development chromosome organization telomeric DNA-containing double minutes formation ERCC4-ERCC1 complex UV-damage excision repair t-circle formation positive regulation of t-circle formation negative regulation of protection from non-homologous end joining at telomere 3' overhang single-stranded DNA endodeoxyribonuclease activity uc009flm.1 uc009flm.2 uc009flm.3 uc009flm.4 
ENSMUST00000003655.9 As3mt ENSMUST00000003655.9 arsenite methyltransferase (from RefSeq NM_020577.3) A6H5W4 AS3MT_MOUSE Cyt19 E9QLU6 ENSMUST00000003655.1 ENSMUST00000003655.2 ENSMUST00000003655.3 ENSMUST00000003655.4 ENSMUST00000003655.5 ENSMUST00000003655.6 ENSMUST00000003655.7 ENSMUST00000003655.8 NM_020577 Q91WU5 Q9QZT1 uc008huc.1 uc008huc.2 uc008huc.3 Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. Reaction=[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S- adenosyl-L-methionine = [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:69460, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17826, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57856, ChEBI:CHEBI:57925, ChEBI:CHEBI:59789, ChEBI:CHEBI:183640; EC=2.1.1.137; Evidence=; Reaction=2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S- adenosyl-L-methionine = 2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:69464, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:23808, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57856, ChEBI:CHEBI:57925, ChEBI:CHEBI:59789, ChEBI:CHEBI:183640; EC=2.1.1.137; Evidence=; Reaction=3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S- adenosyl-L-methionine = 3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine; Xref=Rhea:RHEA:69432, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:27130, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57856, ChEBI:CHEBI:57925, ChEBI:CHEBI:59789, ChEBI:CHEBI:183640; EC=2.1.1.137; Evidence=; Cytoplasm, cytosol Belongs to the methyltransferase superfamily. Arsenite methyltransferase family. cytoplasm mitochondrion cytosol methyltransferase activity toxin metabolic process transferase activity arsonoacetate metabolic process arsenite methyltransferase activity methylarsonite methyltransferase activity methylation response to arsenic-containing substance uc008huc.1 uc008huc.2 uc008huc.3 
ENSMUST00000003659.9 Comp ENSMUST00000003659.9 cartilage oligomeric matrix protein (from RefSeq NM_016685.2) COMP_MOUSE Comp ENSMUST00000003659.1 ENSMUST00000003659.2 ENSMUST00000003659.3 ENSMUST00000003659.4 ENSMUST00000003659.5 ENSMUST00000003659.6 ENSMUST00000003659.7 ENSMUST00000003659.8 G3X8Q4 NM_016685 Q9R0G6 uc009mad.1 uc009mad.2 uc009mad.3 uc009mad.4 Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin (PubMed:32686688). Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (By similarity). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 11-14 calcium ions per subunit. ; Pentamer; disulfide-linked. Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium. Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca(2+), Mg(2+) or Mn(2+)). The greatest amount of binding is seen in the presence of Mn(2+). Interacts with MATN1, MATN3, MATN4 and ACAN. Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate. Interacts with collagen I, II and IX, and interaction with these collagens is dependent on the presence of zinc ions. Interacts with ADAMTS12 (By similarity). Interacts with ITGA7 (By similarity). Q9R0G6; P58397: ADAMTS12; Xeno; NbExp=3; IntAct=EBI-9028018, EBI-9028051; Secreted, extracellular space, extracellular matrix Expressed in cartilage, including nasal, knee epiphyseal and rib tissues. Abundantly expressed in chondrocyte and tendon extracellular matrix (at protein level) (PubMed:32686688). In knee epiphyseal cartilage, expression is detected from 12.5 dpc onwards, with significant up-regulation at 16.5 dpc and again at postnatal day 5. Expressed at least until 10 months of age. The cell attachment motif mediates the attachment to chondrocytes. It mediates the induction of both the IAP family of survival proteins and the antiapoptotic response. The TSP C-terminal domain mediates interaction with FN1 and ACAN. Each of the eight TSP type-3 repeats binds two calcium ions. The TSP C-terminal domain binds three calcium ions. Belongs to the thrombospondin family. skeletal system development ossification fibronectin binding protease binding chondrocyte development endochondral bone growth growth plate cartilage development integrin binding extracellular matrix structural constituent vitamin D binding calcium ion binding protein binding collagen binding extracellular region extracellular space apoptotic process response to unfolded protein cell adhesion blood coagulation heparin binding protein secretion multicellular organism aging animal organ senescence regulation of gene expression vascular smooth muscle contraction protein processing collagen fibril organization bone mineralization regulation of bone mineralization BMP signaling pathway macromolecular complex multicellular organism growth chondrocyte proliferation tendon development BMP binding negative regulation of apoptotic process proteoglycan binding heparan sulfate proteoglycan binding skin development muscle fiber development artery morphogenesis musculoskeletal movement neuromuscular process cartilage development limb development bone morphogenesis platelet aggregation vascular smooth muscle cell development bone growth negative regulation of hemostasis positive regulation of chondrocyte proliferation uc009mad.1 uc009mad.2 uc009mad.3 uc009mad.4 
ENSMUST00000003677.11 Rnf215 ENSMUST00000003677.11 ring finger protein 215, transcript variant 1 (from RefSeq NM_027859.3) ENSMUST00000003677.1 ENSMUST00000003677.10 ENSMUST00000003677.2 ENSMUST00000003677.3 ENSMUST00000003677.4 ENSMUST00000003677.5 ENSMUST00000003677.6 ENSMUST00000003677.7 ENSMUST00000003677.8 ENSMUST00000003677.9 NM_027859 Q5SPX2 Q5SPX3 Q5SPX4 Q9DCW1 RN215_MOUSE uc007hui.1 uc007hui.2 uc007hui.3 uc007hui.4 Membrane ; Multi-pass membrane protein Sequence=CAI25741.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAI25743.1; Type=Erroneous gene model prediction; Evidence=; nucleus cytoplasm late endosome Golgi apparatus ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination metal ion binding response to misfolded protein ubiquitin protein ligase activity uc007hui.1 uc007hui.2 uc007hui.3 uc007hui.4 
ENSMUST00000003681.8 Sec14l2 ENSMUST00000003681.8 SEC14-like lipid binding 2 (from RefSeq NM_144520.2) ENSMUST00000003681.1 ENSMUST00000003681.2 ENSMUST00000003681.3 ENSMUST00000003681.4 ENSMUST00000003681.5 ENSMUST00000003681.6 ENSMUST00000003681.7 NM_144520 Q99J08 S14L2_MOUSE uc007huh.1 uc007huh.2 uc007huh.3 uc007huh.4 Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha- tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell (By similarity). Monomer. Cytoplasm Nucleus Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol. nucleus cytoplasm cytosol enzyme activator activity lipid binding transferase activity, transferring alkyl or aryl (other than methyl) groups positive regulation of cholesterol biosynthetic process uc007huh.1 uc007huh.2 uc007huh.3 uc007huh.4 
ENSMUST00000003687.8 Tgfb3 ENSMUST00000003687.8 transforming growth factor, beta 3 (from RefSeq NM_009368.3) ENSMUST00000003687.1 ENSMUST00000003687.2 ENSMUST00000003687.3 ENSMUST00000003687.4 ENSMUST00000003687.5 ENSMUST00000003687.6 ENSMUST00000003687.7 NM_009368 Q91YU7 Q91YU7_MOUSE Tgfb3 uc007ohn.1 uc007ohn.2 uc007ohn.3 uc007ohn.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Homozygous knockout mice for this gene exhibit cleft palate, delayed pulmonary development and neonatal death. [provided by RefSeq, Aug 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC108426.1, AK145304.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164142 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Homodimer; disulfide-linked. Secreted, extracellular space, extracellular matrix Belongs to the TGF-beta family. activation of MAPK activity response to hypoxia type II transforming growth factor beta receptor binding transforming growth factor beta receptor binding extracellular region extracellular space nucleus cytoplasm transforming growth factor beta receptor signaling pathway salivary gland morphogenesis female pregnancy aging growth factor activity positive regulation of cell proliferation negative regulation of cell proliferation cell surface positive regulation of epithelial to mesenchymal transition negative regulation of macrophage cytokine production secretory granule T-tubule positive regulation of bone mineralization negative regulation of transforming growth factor beta receptor signaling pathway response to progesterone positive regulation of collagen biosynthetic process response to laminar fluid shear stress type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding wound healing identical protein binding neuronal cell body positive regulation of apoptotic process intracellular membrane-bounded organelle response to estrogen ossification involved in bone remodeling cell-cell junction organization positive regulation of transcription, DNA-templated protein heterodimerization activity digestive tract development embryonic neurocranium morphogenesis inner ear development transforming growth factor beta binding positive regulation of protein secretion positive regulation of stress fiber assembly positive regulation of cell division face morphogenesis frontal suture morphogenesis detection of hypoxia negative regulation of vascular smooth muscle cell proliferation positive regulation of occluding junction disassembly uc007ohn.1 uc007ohn.2 uc007ohn.3 uc007ohn.4 
ENSMUST00000003705.12 Aven ENSMUST00000003705.12 apoptosis, caspase activation inhibitor, transcript variant 1 (from RefSeq NM_028844.4) A2AGL4 AVEN_MOUSE ENSMUST00000003705.1 ENSMUST00000003705.10 ENSMUST00000003705.11 ENSMUST00000003705.2 ENSMUST00000003705.3 ENSMUST00000003705.4 ENSMUST00000003705.5 ENSMUST00000003705.6 ENSMUST00000003705.7 ENSMUST00000003705.8 ENSMUST00000003705.9 NM_028844 Q9D9K3 uc008lpe.1 uc008lpe.2 uc008lpe.3 uc008lpe.4 Protects against apoptosis mediated by Apaf-1. Binds Apaf-1, BCL-2 and BAD (Bcl-xl). Endomembrane system ; Peripheral membrane protein Note=Associated with intracellular membranes. molecular_function apoptotic process endomembrane system membrane negative regulation of apoptotic process uc008lpe.1 uc008lpe.2 uc008lpe.3 uc008lpe.4 
ENSMUST00000003717.13 Abcb4 ENSMUST00000003717.13 ATP-binding cassette, sub-family B member 4 (from RefSeq NM_008830.2) Abcb4 B9EK77 ENSMUST00000003717.1 ENSMUST00000003717.10 ENSMUST00000003717.11 ENSMUST00000003717.12 ENSMUST00000003717.2 ENSMUST00000003717.3 ENSMUST00000003717.4 ENSMUST00000003717.5 ENSMUST00000003717.6 ENSMUST00000003717.7 ENSMUST00000003717.8 ENSMUST00000003717.9 MDR3_MOUSE Mdr2 NM_008830 P21440 Pgy-2 Pgy2 Q6LCL9 uc008wkr.1 uc008wkr.2 uc008wkr.3 uc008wkr.4 Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:8106172, PubMed:7912658, PubMed:7592705, PubMed:7814632, PubMed:8725158, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (By similarity). Required for proper phospholipid bile formation (PubMed:8106172). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:7814632, PubMed:8725158). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (PubMed:1990275). Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:66272, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57643, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66273; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:36439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:64612, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36440; Evidence=; Reaction=a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38903, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38904; Evidence=; Translocation activity is inhibited by the ATPase inhibitor vanadate and the calcium channel blocker verapamil (PubMed:7912658). Translocation activity is enhanced by the addition of the bile salt taurocholate (PubMed:7592705). May interact with RACK1. Interacts with HAX1. Cell membrane ulti-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Membrane raft Cytoplasm Cytoplasmic vesicle, clathrin-coated vesicle Note=Transported from the Golgi to the apical bile canalicular membrane in a RACK1-dependent manner. Redistributed into pseudocanaliculi formed between cells in a bezafibrate- or PPARA-dependent manner (By similarity). Localized at the apical canalicular membrane of the epithelial cells lining the lumen of the bile canaliculi and biliary ductules (PubMed:1381362, PubMed:8106172, PubMed:8615769). Localized preferentially in lipid nonraft domains of canalicular plasma membranes (PubMed:23468132). Expressed in the liver (PubMed:1381362, PubMed:8615769) (at protein level). Expressed in adrenal, liver, muscle, spleen and heart (PubMed:2471060). Expressed in multidrug- resistant cell lines (PubMed:1969609). Up-regulated by compounds that cause peroxisome proliferation, such as ciprofibrate and clofibrate (at protein level) (PubMed:8615769). Up-regulated by compounds that cause peroxisome proliferation, such as fenofibrate, ciprofibrate, clofibrate, bezafibrate and gemfibrozil (PubMed:8615769, PubMed:12381268). Phosphorylated. Phosphorylation is required for PC efflux activity. Phosphorylation occurs on serine and threonine residues in a protein kinase A- or C-dependent manner. May be phosphorylated on Thr- 41 and Ser-46. Glycosylated. Mice show severe necrotic damage of hepatocytes, strong portal inflammation, proliferation and destruction of the canalicular and small bile ductular tracts (PubMed:8106172). Display almost complete reduction of biliary phospholipid secretion, although bile salt secretion is normal (PubMed:8106172, PubMed:7814632, PubMed:8725158, PubMed:9366571). Show also reduced cholesterol secretion (PubMed:8106172, PubMed:9366571). Knockout mice lacking both ABCB4 and ATP8B1 show lower hepatic damage compared with the single ABCB4 knockout mice (PubMed:21820390). Display equivalent reduction of biliary phosphatidylcholine (PC) secretion as the single ABCB4 knockout mice (PubMed:21820390). Biliary cholesterol secretion is higher compared to the single ABCB4 knockout mice (PubMed:21820390). Bile salt secretion is normal in both single ABCB4 knockout mice and double ABCB4 and ATP8B1 knockout mice (PubMed:21820390). Biliary excretion of canalicular ectoenzymes, aminopeptidase N and alkaline phosphatase is strongly reduced compared to single ATP8B1 knockout mice (PubMed:21820390). Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Golgi membrane nucleotide binding ATP binding nucleoplasm cytoplasm cytosol plasma membrane focal adhesion lipid transport actin cytoskeleton membrane integral component of membrane apical plasma membrane ATPase activity clathrin-coated vesicle cytoplasmic vesicle positive regulation of cholesterol transport bile acid secretion ATPase activity, coupled to transmembrane movement of substances membrane raft phospholipid translocation intercellular canaliculus transmembrane transport lipid homeostasis positive regulation of phospholipid translocation phosphatidylcholine-translocating ATPase activity phosphatidylethanolamine-translocating ATPase activity ceramide-translocating ATPase activity ceramide translocation response to fenofibrate cellular response to bile acid positive regulation of phospholipid transport drug transmembrane transport uc008wkr.1 uc008wkr.2 uc008wkr.3 uc008wkr.4 
ENSMUST00000003720.5 Crot ENSMUST00000003720.5 carnitine O-octanoyltransferase, transcript variant 6 (from RefSeq NR_184637.1) Cot ENSMUST00000003720.1 ENSMUST00000003720.2 ENSMUST00000003720.3 ENSMUST00000003720.4 NR_184637 OCTC_MOUSE Q921I4 Q9DC50 uc008wkt.1 uc008wkt.2 uc008wkt.3 Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Reaction=(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine; Xref=Rhea:RHEA:17177, ChEBI:CHEBI:16347, ChEBI:CHEBI:18102, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386; EC=2.3.1.137; Evidence=; Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8- dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061, ChEBI:CHEBI:84654; Evidence=; Lipid metabolism; fatty acid beta-oxidation. Peroxisome Belongs to the carnitine/choline acetyltransferase family. mitochondrion peroxisome generation of precursor metabolites and energy lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation carnitine O-octanoyltransferase activity carnitine metabolic process fatty acid transport coenzyme A metabolic process transferase activity transferase activity, transferring acyl groups response to drug intracellular membrane-bounded organelle medium-chain fatty acid metabolic process uc008wkt.1 uc008wkt.2 uc008wkt.3 
ENSMUST00000003726.16 Brd4 ENSMUST00000003726.16 bromodomain containing 4, transcript variant 3 (from RefSeq NM_001286630.1) Brd4 ENSMUST00000003726.1 ENSMUST00000003726.10 ENSMUST00000003726.11 ENSMUST00000003726.12 ENSMUST00000003726.13 ENSMUST00000003726.14 ENSMUST00000003726.15 ENSMUST00000003726.2 ENSMUST00000003726.3 ENSMUST00000003726.4 ENSMUST00000003726.5 ENSMUST00000003726.6 ENSMUST00000003726.7 ENSMUST00000003726.8 ENSMUST00000003726.9 NM_001286630 Q3UH70 Q3UH70_MOUSE uc008bwb.1 uc008bwb.2 uc008bwb.3 uc008bwb.4 uc008bwb.5 This gene was temporarily named bromodomain-containing 5 (Brd5) and was renamed bromodomain-containing 4 (Brd4). [provided by RefSeq, Jul 2008]. Chromosome Nucleus regulation of transcription involved in G1/S transition of mitotic cell cycle condensed nuclear chromosome transcription factor activity, transcription factor recruiting p53 binding chromatin binding nucleus nucleoplasm cytosol protein phosphorylation RNA polymerase II carboxy-terminal domain kinase activity positive regulation of G2/M transition of mitotic cell cycle enzyme binding positive regulation of transcription elongation from RNA polymerase II promoter positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of inflammatory response lysine-acetylated histone binding RNA polymerase II C-terminal domain binding regulation of phosphorylation of RNA polymerase II C-terminal domain positive regulation of histone H3-K36 trimethylation uc008bwb.1 uc008bwb.2 uc008bwb.3 uc008bwb.4 uc008bwb.5 
ENSMUST00000003754.8 Calb2 ENSMUST00000003754.8 calbindin 2, transcript variant 1 (from RefSeq NM_007586.2) CALB2_MOUSE ENSMUST00000003754.1 ENSMUST00000003754.2 ENSMUST00000003754.3 ENSMUST00000003754.4 ENSMUST00000003754.5 ENSMUST00000003754.6 ENSMUST00000003754.7 NM_007586 Q08331 Q60964 Q9JM81 uc009nko.1 uc009nko.2 Calretinin is a calcium-binding protein which is abundant in auditory neurons. Belongs to the calbindin family. calcium ion binding nucleus cytoplasm cytosol gap junction dendrite stereocilium cuticular plate neuron projection synapse metal ion binding synaptic membrane presynapse regulation of presynaptic cytosolic calcium ion concentration calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration regulation of long-term synaptic potentiation uc009nko.1 uc009nko.2 
ENSMUST00000003759.11 Ciao1 ENSMUST00000003759.11 cytosolic iron-sulfur protein assembly 1 (from RefSeq NM_025296.4) CIAO1_MOUSE Ciao1 ENSMUST00000003759.1 ENSMUST00000003759.10 ENSMUST00000003759.2 ENSMUST00000003759.3 ENSMUST00000003759.4 ENSMUST00000003759.5 ENSMUST00000003759.6 ENSMUST00000003759.7 ENSMUST00000003759.8 ENSMUST00000003759.9 NM_025296 Q99KN2 Q9DCZ7 Wdr39 uc008mfb.1 uc008mfb.2 uc008mfb.3 Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (By similarity). Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle- associated MMXD complex it may play a role in chromosome segregation (By similarity). Component of the CIA complex. Interacts with CIAO2A and forms a complex with CIAO2B and MMS19; the interactions with CIAO2A and CIAO2B are mutually exclusive (PubMed:23891004) (By similarity). Interacts with CHD1L, ERCC2, IREB2 and POLD1 (By similarity). Component of the MMXD complex, which includes CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5. Interacts with WT1 (By similarity). Interacts with CIAO3 (By similarity). Interacts (via LYR motif) with HSC20. Cytoplasm Belongs to the WD repeat CIA1 family. transcription factor activity, sequence-specific DNA binding cytoplasm regulation of transcription from RNA polymerase II promoter chromosome segregation iron-sulfur cluster assembly MMXD complex CIA complex protein maturation by iron-sulfur cluster transfer uc008mfb.1 uc008mfb.2 uc008mfb.3 
ENSMUST00000003762.8 Has1 ENSMUST00000003762.8 hyaluronan synthase 1 (from RefSeq NM_008215.2) ENSMUST00000003762.1 ENSMUST00000003762.2 ENSMUST00000003762.3 ENSMUST00000003762.4 ENSMUST00000003762.5 ENSMUST00000003762.6 ENSMUST00000003762.7 HYAS1_MOUSE Has NM_008215 Q61647 uc008apr.1 uc008apr.2 uc008apr.3 uc008apr.4 Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate. Reaction=[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N- acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP; Xref=Rhea:RHEA:20465, Rhea:RHEA-COMP:12583, Rhea:RHEA-COMP:12585, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:132153, ChEBI:CHEBI:132154; EC=2.4.1.212; Evidence=; Reaction=N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP- alpha-D-glucuronate = [hyaluronan](n+1) + H(+) + UDP; Xref=Rhea:RHEA:12528, Rhea:RHEA-COMP:12585, Rhea:RHEA-COMP:12587, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132153, ChEBI:CHEBI:132154; EC=2.4.1.212; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Kinetic parameters: KM=0.8 mM for UDP-Glc-NAc (at pH 7.1 and 37 degrees Celsius, in the presence of 15 mM MgCl2) ; KM=0.7 mM for UDP-Glc-UA (at pH 7.1 and 37 degrees Celsius, in the presence of 15 mM MgCl2) ; Glycan biosynthesis; hyaluronan biosynthesis. Membrane ; Multi-pass membrane protein Belongs to the NodC/HAS family. cytoplasm integral component of plasma membrane negative regulation of fibroblast migration membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups hyaluronan biosynthetic process cellular response to platelet-derived growth factor stimulus identical protein binding estrous cycle extracellular polysaccharide biosynthetic process hyaluronan synthase activity extracellular matrix assembly uc008apr.1 uc008apr.2 uc008apr.3 uc008apr.4 
ENSMUST00000003826.8 Htr3a ENSMUST00000003826.8 5-hydroxytryptamine (serotonin) receptor 3A, transcript variant 1 (from RefSeq NM_013561.2) 5HT3A_MOUSE 5ht3 E9QLC0 ENSMUST00000003826.1 ENSMUST00000003826.2 ENSMUST00000003826.3 ENSMUST00000003826.4 ENSMUST00000003826.5 ENSMUST00000003826.6 ENSMUST00000003826.7 Htr3 Htr3a NM_013561 P23979 Q61225 Q61226 uc009pip.1 uc009pip.2 uc009pip.3 Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation- selective channel complexes, which when activated cause fast, depolarizing responses in neurons. Reaction=Na(+)(in) = Na(+)(out); Xref=Rhea:RHEA:34963, ChEBI:CHEBI:29101; Evidence=; Reaction=K(+)(in) = K(+)(out); Xref=Rhea:RHEA:29463, ChEBI:CHEBI:29103; Evidence=; Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671, ChEBI:CHEBI:29108; Evidence=; Reaction=Mg(2+)(in) = Mg(2+)(out); Xref=Rhea:RHEA:29827, ChEBI:CHEBI:18420; Evidence=; Forms homopentameric as well as heteropentameric serotonin- activated cation-selective channel complexes with HTR3B or HTR3C or HTR3D or HTR3E. The homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Heteropentameric complexes display properties which resemble that of neuronal serotonin-activated channels in vivo. Interacts with RIC3. P23979; P23979: Htr3a; NbExp=2; IntAct=EBI-11295097, EBI-11295097; P23979-1; P23979-1: Htr3a; NbExp=7; IntAct=EBI-15824923, EBI-15824923; Postsynaptic cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=5-HT3R-A; IsoId=P23979-1; Sequence=Displayed; Name=5-HT3R-AS; IsoId=P23979-2; Sequence=VSP_000079; Brain, spinal cord, and heart. The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub- subfamily. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity cytoplasm plasma membrane integral component of plasma membrane ion transport signal transduction serotonin receptor signaling pathway chemical synaptic transmission ligand-gated ion channel activity membrane integral component of membrane serotonin-gated cation channel activity cell junction axon cleavage furrow positive regulation of ion transmembrane transporter activity ion transmembrane transport regulation of membrane potential identical protein binding neuron projection neuronal cell body synapse postsynaptic membrane neurological system process serotonin binding glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane serotonin-activated cation-selective channel complex uc009pip.1 uc009pip.2 uc009pip.3 
ENSMUST00000003843.16 Man1a ENSMUST00000003843.16 mannosidase 1, alpha (from RefSeq NM_008548.5) ENSMUST00000003843.1 ENSMUST00000003843.10 ENSMUST00000003843.11 ENSMUST00000003843.12 ENSMUST00000003843.13 ENSMUST00000003843.14 ENSMUST00000003843.15 ENSMUST00000003843.2 ENSMUST00000003843.3 ENSMUST00000003843.4 ENSMUST00000003843.5 ENSMUST00000003843.6 ENSMUST00000003843.7 ENSMUST00000003843.8 ENSMUST00000003843.9 Man1a NM_008548 Q544T7 Q544T7_MOUSE uc007fbw.1 uc007fbw.2 uc007fbw.3 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= Protein modification; protein glycosylation. Belongs to the glycosyl hydrolase 47 family. catalytic activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity calcium ion binding endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cytosol metabolic process membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds uc007fbw.1 uc007fbw.2 uc007fbw.3 
ENSMUST00000003850.8 Itpkc ENSMUST00000003850.8 inositol 1,4,5-trisphosphate 3-kinase C (from RefSeq NM_181593.3) ENSMUST00000003850.1 ENSMUST00000003850.2 ENSMUST00000003850.3 ENSMUST00000003850.4 ENSMUST00000003850.5 ENSMUST00000003850.6 ENSMUST00000003850.7 IP3KC_MOUSE NM_181593 Q3U384 Q7TS72 uc009fvk.1 uc009fvk.2 uc009fvk.3 Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5- trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (By similarity). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity). Reaction=1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+); Xref=Rhea:RHEA:11020, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57895, ChEBI:CHEBI:203600, ChEBI:CHEBI:456216; EC=2.7.1.127; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11021; Evidence=; Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4. Q7TS72; O54824: Il16; NbExp=3; IntAct=EBI-648015, EBI-641708; Nucleus Cytoplasm Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. Belongs to the inositol phosphokinase (IPK) family. nucleotide binding protein binding calmodulin binding ATP binding nucleus cytoplasm inositol-1,4,5-trisphosphate 3-kinase activity kinase activity phosphorylation nuclear speck transferase activity inositol phosphate biosynthetic process uc009fvk.1 uc009fvk.2 uc009fvk.3 
ENSMUST00000003857.7 Shkbp1 ENSMUST00000003857.7 Sh3kbp1 binding protein 1 (from RefSeq NM_138676.2) ENSMUST00000003857.1 ENSMUST00000003857.2 ENSMUST00000003857.3 ENSMUST00000003857.4 ENSMUST00000003857.5 ENSMUST00000003857.6 NM_138676 Q3TUN8 Q6P7W2 Q9ES31 SHKB1_MOUSE Sb1 uc009fvw.1 uc009fvw.2 uc009fvw.3 Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation (PubMed:21830225). Monomer (By similarity). Interacts with CUL3; interaction is direct and forms a 5:5 heterodecamer (By similarity). Interacts (via PXXXPR motifs) with SH3KBP1 (via SH3 domains) (PubMed:11152963, PubMed:21830225). Directly interacts with cathepsin B/CTSB (By similarity). Q6P7W2; Q9JJ40: Pdzk1; Xeno; NbExp=7; IntAct=EBI-7713890, EBI-7713572; Lysosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P7W2-1; Sequence=Displayed; Name=2; IsoId=Q6P7W2-2; Sequence=VSP_028875, VSP_028876; Belongs to the KCTD3 family. protein binding cellular_component lysosome positive regulation of epidermal growth factor receptor signaling pathway protein homooligomerization uc009fvw.1 uc009fvw.2 uc009fvw.3 
ENSMUST00000003860.13 Coq8b ENSMUST00000003860.13 coenzyme Q8B (from RefSeq NM_133770.2) Adck4 Coq8b E9QLB8 E9QLB8_MOUSE ENSMUST00000003860.1 ENSMUST00000003860.10 ENSMUST00000003860.11 ENSMUST00000003860.12 ENSMUST00000003860.2 ENSMUST00000003860.3 ENSMUST00000003860.4 ENSMUST00000003860.5 ENSMUST00000003860.6 ENSMUST00000003860.7 ENSMUST00000003860.8 ENSMUST00000003860.9 NM_133770 uc009fvm.1 uc009fvm.2 uc009fvm.3 Belongs to the protein kinase superfamily. ADCK protein kinase family. mitochondrion ubiquinone biosynthetic process cerebellar Purkinje cell layer morphogenesis uc009fvm.1 uc009fvm.2 uc009fvm.3 
ENSMUST00000003876.10 Brd8 ENSMUST00000003876.10 bromodomain containing 8, transcript variant 1 (from RefSeq NM_030147.3) BRD8_MOUSE ENSMUST00000003876.1 ENSMUST00000003876.2 ENSMUST00000003876.3 ENSMUST00000003876.4 ENSMUST00000003876.5 ENSMUST00000003876.6 ENSMUST00000003876.7 ENSMUST00000003876.8 ENSMUST00000003876.9 NM_030147 Q3TSZ2 Q8C049 Q8R3B7 Q8R583 Q8VDP0 uc008ekv.1 uc008ekv.2 uc008ekv.3 uc008ekv.4 May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. BRD8 isoform 2 interacts with RXRA/NR2B1 and THRB/ERBA2. Component of a SWR1-like complex (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R3B7-1; Sequence=Displayed; Name=2; IsoId=Q8R3B7-2; Sequence=VSP_038218; Sequence=AAH23160.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=AAH25644.1; Type=Erroneous initiation; Evidence=; Sequence=BAC27812.1; Type=Erroneous initiation; Evidence=; Swr1 complex molecular_function nucleus nucleoplasm mitochondrion chromatin organization NuA4 histone acetyltransferase complex regulation of growth histone H4 acetylation histone H2A acetylation positive regulation of transcription from RNA polymerase II promoter uc008ekv.1 uc008ekv.2 uc008ekv.3 uc008ekv.4 
ENSMUST00000003898.12 Ece2 ENSMUST00000003898.12 endothelin converting enzyme 2, transcript variant 4 (from RefSeq NM_139293.2) B2RQR8 E9Q896 ECE2_MOUSE ENSMUST00000003898.1 ENSMUST00000003898.10 ENSMUST00000003898.11 ENSMUST00000003898.2 ENSMUST00000003898.3 ENSMUST00000003898.4 ENSMUST00000003898.5 ENSMUST00000003898.6 ENSMUST00000003898.7 ENSMUST00000003898.8 ENSMUST00000003898.9 Ece2 NM_139293 uc007yqm.1 uc007yqm.2 uc007yqm.3 Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides (By similarity). May play a role in amyloid-beta processing (PubMed:12464614). Reaction=Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.; EC=3.4.24.71; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Golgi apparatus membrane ; Single-pass type II membrane protein Cytoplasmic vesicle, secretory vesicle membrane Event=Alternative splicing; Named isoforms=4; Name=Ece2-1; IsoId=B2RQR8-1; Sequence=Displayed; Name=Ece2-2; IsoId=B2RQR8-2; Sequence=VSP_059326; Name=Eef1akmt4-Ece2-1; Synonyms=ECE-2a-1; IsoId=P0DPD9-1, Q80Z60-1; Sequence=External; Name=Eef1akmt4-Ece2-2; Synonyms=ECE-2a-2; IsoId=P0DPD9-2, Q80Z60-2; Sequence=External; Eef1akmt4-Ece2 and Ece2 double mutant mice are fertile and healthy, and do not display any abnormality in terms of growth or aging. Belongs to the peptidase M13 family. Golgi membrane metalloendopeptidase activity Golgi apparatus trans-Golgi network proteolysis peptidase activity metallopeptidase activity membrane integral component of membrane peptide hormone processing hydrolase activity transport vesicle membrane cytoplasmic vesicle membrane cytoplasmic vesicle metal ion binding uc007yqm.1 uc007yqm.2 uc007yqm.3 
ENSMUST00000003906.13 Farsa ENSMUST00000003906.13 phenylalanyl-tRNA synthetase, alpha subunit, transcript variant 1 (from RefSeq NM_025648.3) ENSMUST00000003906.1 ENSMUST00000003906.10 ENSMUST00000003906.11 ENSMUST00000003906.12 ENSMUST00000003906.2 ENSMUST00000003906.3 ENSMUST00000003906.4 ENSMUST00000003906.5 ENSMUST00000003906.6 ENSMUST00000003906.7 ENSMUST00000003906.8 ENSMUST00000003906.9 Farsla NM_025648 Q3U3Q9 Q8C0C7 Q91WR4 Q922S1 SYFA_MOUSE uc009mnu.1 uc009mnu.2 uc009mnu.3 uc009mnu.4 Reaction=ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe); Xref=Rhea:RHEA:19413, Rhea:RHEA-COMP:9668, Rhea:RHEA-COMP:9699, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58095, ChEBI:CHEBI:78442, ChEBI:CHEBI:78531, ChEBI:CHEBI:456215; EC=6.1.1.20; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB. Cytoplasm Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. tRNA binding nucleotide binding aminoacyl-tRNA ligase activity phenylalanine-tRNA ligase activity ATP binding cytoplasm cytosol translation phenylalanyl-tRNA aminoacylation phenylalanine-tRNA ligase complex ligase activity tRNA aminoacylation protein heterotetramerization uc009mnu.1 uc009mnu.2 uc009mnu.3 uc009mnu.4 
ENSMUST00000003910.13 Dnase2a ENSMUST00000003910.13 deoxyribonuclease II alpha, transcript variant 1 (from RefSeq NM_010062.4) Dnase2a ENSMUST00000003910.1 ENSMUST00000003910.10 ENSMUST00000003910.11 ENSMUST00000003910.12 ENSMUST00000003910.2 ENSMUST00000003910.3 ENSMUST00000003910.4 ENSMUST00000003910.5 ENSMUST00000003910.6 ENSMUST00000003910.7 ENSMUST00000003910.8 ENSMUST00000003910.9 NM_010062 Q3UM14 Q3UM14_MOUSE uc009moa.1 uc009moa.2 uc009moa.3 Reaction=Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'- phosphooligonucleotide end-products.; EC=3.1.22.1; Evidence=; Belongs to the DNase II family. endodeoxyribonuclease activity deoxyribonuclease II activity DNA metabolic process uc009moa.1 uc009moa.2 uc009moa.3 
ENSMUST00000003911.13 Rad23a ENSMUST00000003911.13 RAD23 homolog A, nucleotide excision repair protein, transcript variant 2 (from RefSeq NM_009010.6) ENSMUST00000003911.1 ENSMUST00000003911.10 ENSMUST00000003911.11 ENSMUST00000003911.12 ENSMUST00000003911.2 ENSMUST00000003911.3 ENSMUST00000003911.4 ENSMUST00000003911.5 ENSMUST00000003911.6 ENSMUST00000003911.7 ENSMUST00000003911.8 ENSMUST00000003911.9 NM_009010 Q8CAP3 Q8CAP3_MOUSE Rad23a uc009mnk.1 uc009mnk.2 uc009mnk.3 uc009mnk.4 Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair. Nucleus Cytoplasm Belongs to the RAD23 family. damaged DNA binding nucleus nucleotide-excision repair proteasome-mediated ubiquitin-dependent protein catabolic process uc009mnk.1 uc009mnk.2 uc009mnk.3 uc009mnk.4 
ENSMUST00000003912.7 Calr ENSMUST00000003912.7 calreticulin (from RefSeq NM_007591.3) CALR_MOUSE ENSMUST00000003912.1 ENSMUST00000003912.2 ENSMUST00000003912.3 ENSMUST00000003912.4 ENSMUST00000003912.5 ENSMUST00000003912.6 NM_007591 P14211 Q3TVD2 uc009mnp.1 uc009mnp.2 uc009mnp.3 Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:20880849, PubMed:21652723). Interacts with the DNA- binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non- activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). Monomer. Interacts with GABARAP, NR3C1, PDIA3/ERp57 and TRIM21. Interacts (via P-domain) with PDIA5 (By similarity). Interacts with PPIB (PubMed:20801878). Interacts with SPACA9 (PubMed:24256100). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (PubMed:16931514). Interacts with CLCC1 (By similarity). P14211; P12023: App; NbExp=4; IntAct=EBI-644340, EBI-78814; P14211; P57716: Ncstn; NbExp=2; IntAct=EBI-644340, EBI-998934; P14211; P49769: Psen1; NbExp=3; IntAct=EBI-644340, EBI-990067; Endoplasmic reticulum lumen Cytoplasm, cytosol Cytolytic granule Secreted, extracellular space, extracellular matrix Cell surface Sarcoplasmic reticulum lumen Cytoplasmic vesicle, secretory vesicle, Cortical granule. Note=Also found in cell surface (T cells), cytosol and extracellular matrix. During oocyte maturation and after parthenogenetic activation accumulates in cortical granules. In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (By similarity). In cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation (By similarity). Can be divided into a N-terminal globular domain, a proline- rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity). The interaction with glycans occurs through a binding site in the globular lectin domain. The zinc binding sites are localized to the N-domain. Associates with PDIA3 through the tip of the extended arm formed by the P-domain. Belongs to the calreticulin family. negative regulation of transcription from RNA polymerase II promoter acrosomal vesicle peptide antigen assembly with MHC class I protein complex mRNA binding integrin binding iron ion binding calcium ion binding protein binding extracellular region extracellular space nucleus nuclear envelope cytoplasm endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane smooth endoplasmic reticulum Golgi apparatus cytosol polysome protein folding protein export from nucleus spermatogenesis positive regulation of cell proliferation external side of plasma membrane cell surface response to organic substance positive regulation of endothelial cell migration positive regulation of gene expression membrane sarcoplasmic reticulum negative regulation of translation carbohydrate binding cortical actin cytoskeleton organization endoplasmic reticulum unfolded protein response ubiquitin protein ligase binding response to estradiol macromolecular complex sarcoplasmic reticulum lumen negative regulation of intracellular steroid hormone receptor signaling pathway response to testosterone protein localization to nucleus regulation of meiotic nuclear division peptide binding response to drug hormone binding MHC class I peptide loading complex intracellular membrane-bounded organelle endoplasmic reticulum quality control compartment phagocytic vesicle negative regulation of neuron differentiation positive regulation of cell cycle negative regulation of transcription, DNA-templated metal ion binding negative regulation of retinoic acid receptor signaling pathway perinuclear region of cytoplasm androgen receptor binding positive regulation of phagocytosis protein stabilization unfolded protein binding cardiac muscle cell differentiation negative regulation of cell cycle arrest cellular response to lithium ion cellular response to organic substance cellular senescence positive regulation of substrate adhesion-dependent cell spreading negative regulation of trophoblast cell migration positive regulation of NIK/NF-kappaB signaling positive regulation of dendritic cell chemotaxis uc009mnp.1 uc009mnp.2 uc009mnp.3 
ENSMUST00000003946.9 Nob1 ENSMUST00000003946.9 NIN1/RPN12 binding protein 1 homolog (from RefSeq NM_026277.3) ENSMUST00000003946.1 ENSMUST00000003946.2 ENSMUST00000003946.3 ENSMUST00000003946.4 ENSMUST00000003946.5 ENSMUST00000003946.6 ENSMUST00000003946.7 ENSMUST00000003946.8 NM_026277 NOB1_MOUSE Q7TPR3 Q8BW10 Q9CRD7 uc009nhr.1 uc009nhr.2 uc009nhr.3 May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). May interact with UPF2 (Probable). Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex) (By similarity). Nucleus Belongs to the NOB1 family. cleavage involved in rRNA processing endoribonuclease activity nucleus nucleolus cytoplasm visual perception maturation of SSU-rRNA preribosome, small subunit precursor ribosomal small subunit biogenesis metal ion binding RNA phosphodiester bond hydrolysis, endonucleolytic uc009nhr.1 uc009nhr.2 uc009nhr.3 
ENSMUST00000003947.9 Nqo1 ENSMUST00000003947.9 NAD(P)H dehydrogenase, quinone 1 (from RefSeq NM_008706.5) Dia4 ENSMUST00000003947.1 ENSMUST00000003947.2 ENSMUST00000003947.3 ENSMUST00000003947.4 ENSMUST00000003947.5 ENSMUST00000003947.6 ENSMUST00000003947.7 ENSMUST00000003947.8 NM_008706 NQO1_MOUSE Nmo1 Nmor1 Q64669 uc009nhq.1 uc009nhq.2 uc009nhq.3 Flavin-containing quinone reductase that catalyzes two- electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (PubMed:8999809) (By similarity). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (By similarity). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (By similarity). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (By similarity). Reaction=a quinone + H(+) + NADH = a quinol + NAD(+); Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=1.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46161; Evidence=; Reaction=a quinone + H(+) + NADPH = a quinol + NADP(+); Xref=Rhea:RHEA:46164, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132124; EC=1.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46165; Evidence=; Reaction=H(+) + NADH + ubiquinone-10 = NAD(+) + ubiquinol-10; Xref=Rhea:RHEA:61984, ChEBI:CHEBI:15378, ChEBI:CHEBI:46245, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:64183; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61985; Evidence=; Reaction=H(+) + menadione + NADH = menadiol + NAD(+); Xref=Rhea:RHEA:69695, ChEBI:CHEBI:6746, ChEBI:CHEBI:15378, ChEBI:CHEBI:28869, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69696; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Kinetic parameters: KM=4.3 uM for menadione ; KM=210 uM for NADH ; KM=1280 uM for 5-(aziridin-1-yl)-2,4-dinitrobenzamide ; Vmax=1800 umol/min/mg enzyme toward menadione ; Vmax=20 nmol/min/mg enzyme toward 5-(aziridin-1-yl)-2,4- dinitrobenzamide ; Homodimer (PubMed:10706635). Interacts with PDLIM4 isoform 2; this interaction stabilizes PDLIM4 isoform 2 in response to oxidative stress and protects it from ubiquitin-independent degradation by the core 20S proteasome (By similarity). Interacts with TP73 (via SAM domain); this interaction is NADH-dependent, stabilizes TP73 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome (By similarity). Interacts with TP53; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome (By similarity). Cytoplasm, cytosol By polycyclic hydrocarbons such as dioxin (Governed by the aromatic hydrocarbon-responsive (AH) locus). Belongs to the NAD(P)H dehydrogenase (quinone) family. NAD(P)H dehydrogenase (quinone) activity superoxide dismutase activity cytoplasm cytosol superoxide metabolic process response to oxidative stress aging response to nutrient electron carrier activity response to organic cyclic compound oxidoreductase activity removal of superoxide radicals electron transport chain dendrite response to estradiol identical protein binding neuronal cell body negative regulation of apoptotic process negative regulation of catalytic activity positive regulation of neuron apoptotic process response to ethanol response to electrical stimulus oxidation-reduction process cellular response to hydrogen peroxide cellular response to metal ion response to nitrogen compound response to hydrogen sulfide uc009nhq.1 uc009nhq.2 uc009nhq.3 
ENSMUST00000003961.16 Ppfia3 ENSMUST00000003961.16 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 (from RefSeq NM_029741.2) B8QI35 ENSMUST00000003961.1 ENSMUST00000003961.10 ENSMUST00000003961.11 ENSMUST00000003961.12 ENSMUST00000003961.13 ENSMUST00000003961.14 ENSMUST00000003961.15 ENSMUST00000003961.2 ENSMUST00000003961.3 ENSMUST00000003961.4 ENSMUST00000003961.5 ENSMUST00000003961.6 ENSMUST00000003961.7 ENSMUST00000003961.8 ENSMUST00000003961.9 LIPA3_MOUSE NM_029741 P60469 uc012fki.1 uc012fki.2 uc012fki.3 May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Binds RIMS1, RIMS2, RIMS3 and RIMS4. Cytoplasm Cytoplasmic vesicle, secretory vesicle, acrosome Note=Also detected in epididymosome. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P60469-1; Sequence=Displayed; Name=2; IsoId=P60469-2; Sequence=VSP_057923; Detected in sperm (at protein level). The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS. Belongs to the liprin family. Liprin-alpha subfamily. acrosomal vesicle molecular_function cytoplasm neurotransmitter secretion synaptic vesicle exocytosis synaptic vesicle docking cytoplasmic vesicle synapse regulation of short-term neuronal synaptic plasticity presynaptic active zone presynaptic active zone cytoplasmic component epididymosome glutamatergic synapse uc012fki.1 uc012fki.2 uc012fki.3 
ENSMUST00000003964.17 Gys1 ENSMUST00000003964.17 glycogen synthase 1, muscle (from RefSeq NM_030678.3) ENSMUST00000003964.1 ENSMUST00000003964.10 ENSMUST00000003964.11 ENSMUST00000003964.12 ENSMUST00000003964.13 ENSMUST00000003964.14 ENSMUST00000003964.15 ENSMUST00000003964.16 ENSMUST00000003964.2 ENSMUST00000003964.3 ENSMUST00000003964.4 ENSMUST00000003964.5 ENSMUST00000003964.6 ENSMUST00000003964.7 ENSMUST00000003964.8 ENSMUST00000003964.9 GYS1_MOUSE Gys Gys3 NM_030678 P54859 Q3TBN4 Q8BQG4 Q8VEB0 Q9Z1E4 uc009gve.1 uc009gve.2 uc009gve.3 Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Reaction=[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)- alpha-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:18549, Rhea:RHEA- COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18550; Evidence=; Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6- phosphate as an allosteric activator; when phosphorylated it does (By similarity). Glycan biosynthesis; glycogen biosynthesis. Part of the GYS1-GYG1 complex, a heterooctamer composed of a tetramer of GYS1 and 2 dimers of GYG1, where each GYS1 protomer binds to one GYG1 subunit (via GYG1 C-terminus); the GYS1 tetramer may dissociate from GYG1 dimers to continue glycogen polymerization on its own. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser- 645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme (By similarity). Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Belongs to the glycosyltransferase 3 family. catalytic activity glycogen (starch) synthase activity protein binding glucose binding cytoplasm glycogen metabolic process glycogen biosynthetic process heart development metabolic process inclusion body transferase activity transferase activity, transferring glycosyl groups protein kinase binding glycogen synthase activity, transferring glucose-1-phosphate uc009gve.1 uc009gve.2 uc009gve.3 
ENSMUST00000003971.10 Lin7b ENSMUST00000003971.10 lin-7 homolog B, crumbs cell polarity complex component (from RefSeq NM_011698.1) ENSMUST00000003971.1 ENSMUST00000003971.2 ENSMUST00000003971.3 ENSMUST00000003971.4 ENSMUST00000003971.5 ENSMUST00000003971.6 ENSMUST00000003971.7 ENSMUST00000003971.8 ENSMUST00000003971.9 LIN7B_MOUSE Mals2 NM_011698 O88951 Veli2 uc009guv.1 uc009guv.2 uc009guv.3 Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface. Forms a complex with CASK and CASKIN1 (By similarity). Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2- LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (PubMed:10846156). Forms a heterotrimeric complex composed of MMP5, LIN7B and PATJ; the N-terminal L27 domain of PALS1 interacts with the L27 domain of PATJ and the C-terminal L27 domain of PALS1 interacts with the L27 domain of LIN7B (PubMed:22337881). Forms a heterotrimeric complex with DLG1 and CASK via their L27 domains (PubMed:22337881, PubMed:15863617). Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain (By similarity). The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains (By similarity). Associates with KIF17 via APBA1 (By similarity). Interacts with ASIC3 (PubMed:15317815). Interacts with TOPK. Interacts with RTKN (By similarity). Interacts with APBA1 (PubMed:15863617). Interacts with MPP7 (By similarity). Interacts with DLG2 (PubMed:9753324). Interacts with DLG3 (PubMed:9753324). Cell membrane ; Peripheral membrane protein Basolateral cell membrane ; Peripheral membrane protein Cell junction Postsynaptic density membrane ; Peripheral membrane protein Cell junction, tight junction Note=Mainly basolateral in renal epithelial cells. Expressed in the kidney; predominantly in the vasa recta. The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane. The PDZ domain regulates endocytosis and recycling of the receptor at the membrane. The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes. Belongs to the lin-7 family. protein binding plasma membrane cell-cell junction bicellular tight junction exocytosis neurotransmitter secretion postsynaptic density protein transport membrane basolateral plasma membrane protein domain specific binding cell junction PDZ domain binding neuron projection maintenance of epithelial cell apical/basal polarity synapse postsynaptic membrane L27 domain binding MPP7-DLG1-LIN7 complex presynapse protein localization to basolateral plasma membrane uc009guv.1 uc009guv.2 uc009guv.3 
ENSMUST00000003981.6 Il7r ENSMUST00000003981.6 interleukin 7 receptor, transcript variant 2 (from RefSeq NM_008372.4) ENSMUST00000003981.1 ENSMUST00000003981.2 ENSMUST00000003981.3 ENSMUST00000003981.4 ENSMUST00000003981.5 IL7RA_MOUSE NM_008372 P16872 Q9R0C1 uc007vfo.1 uc007vfo.2 uc007vfo.3 uc007vfo.4 Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M29697.1, AK042264.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. Membrane; Single-pass type I membrane protein. Spleen, thymus and fetal liver. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form. Belongs to the type I cytokine receptor family. Type 4 subfamily. cell morphogenesis negative regulation of T cell mediated cytotoxicity immunoglobulin production cytokine receptor activity plasma membrane positive regulation of cell proliferation regulation of cell size external side of plasma membrane positive regulation of gene expression membrane integral component of membrane cytokine-mediated signaling pathway T cell differentiation positive regulation of T cell differentiation in thymus B cell proliferation lymph node development homeostasis of number of cells negative regulation of T cell apoptotic process positive regulation of STAT cascade uc007vfo.1 uc007vfo.2 uc007vfo.3 uc007vfo.4 
ENSMUST00000004036.6 Efnb3 ENSMUST00000004036.6 ephrin B3 (from RefSeq NM_007911.5) ENSMUST00000004036.1 ENSMUST00000004036.2 ENSMUST00000004036.3 ENSMUST00000004036.4 ENSMUST00000004036.5 Efnb3 NM_007911 Q543Q7 Q543Q7_MOUSE RP23-56I20.5-001 uc007jqi.1 uc007jqi.2 uc007jqi.3 uc007jqi.4 Belongs to the ephrin family. Lacks conserved residue(s) required for the propagation of feature annotation. plasma membrane membrane integral component of membrane ephrin receptor binding ephrin receptor signaling pathway glutamatergic synapse integral component of postsynaptic density membrane uc007jqi.1 uc007jqi.2 uc007jqi.3 uc007jqi.4 
ENSMUST00000004050.7 Mmd ENSMUST00000004050.7 monocyte to macrophage differentiation-associated, transcript variant 1 (from RefSeq NM_026178.2) ENSMUST00000004050.1 ENSMUST00000004050.2 ENSMUST00000004050.3 ENSMUST00000004050.4 ENSMUST00000004050.5 ENSMUST00000004050.6 Mmd NM_026178 PAQRB_MOUSE Paqr11 Q3TAU1 Q5SVU7 Q9CQY7 uc007kwp.1 uc007kwp.2 uc007kwp.3 Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion. Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Belongs to the ADIPOR family. Sequence=CAI24626.1; Type=Erroneous gene model prediction; Evidence=; protein kinase activity lysosome lysosomal membrane endosome Golgi apparatus protein phosphorylation membrane integral component of membrane cytolysis late endosome membrane regulation of protein localization positive regulation of neuron differentiation positive regulation of protein kinase activity uc007kwp.1 uc007kwp.2 uc007kwp.3 
ENSMUST00000004051.8 Hlf ENSMUST00000004051.8 hepatic leukemia factor, transcript variant 1 (from RefSeq NM_172563.4) ENSMUST00000004051.1 ENSMUST00000004051.2 ENSMUST00000004051.3 ENSMUST00000004051.4 ENSMUST00000004051.5 ENSMUST00000004051.6 ENSMUST00000004051.7 HLF_MOUSE NM_172563 Q6PF83 Q8BW74 uc007kws.1 uc007kws.2 uc007kws.3 Binds DNA specifically as homodimer or heterodimer with other PAR factors. Nucleus Accumulates according to a robust circadian rhythm. Displays only a moderate amplitude in the liver (1.6-fold) and none in the brain. Mice deficient for all three PAR bZIP proteins (DBP, HLF and TEF) display a dramatically shortened life span and are highly susceptible to generalized spontaneous and audiogenic epilepsies (due for example to the noise of a vacuum cleaner) that are frequently lethal. The down-regulation of pyridoxal kinase (Pdxk) expression in these mice may participate in this seizure phenotype. Belongs to the bZIP family. PAR subfamily. Sequence=AAH57693.1; Type=Erroneous initiation; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter skeletal muscle cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter rhythmic process uc007kws.1 uc007kws.2 uc007kws.3 
ENSMUST00000004054.13 Kpna1 ENSMUST00000004054.13 karyopherin subunit alpha 1, transcript variant 1 (from RefSeq NM_008465.6) ENSMUST00000004054.1 ENSMUST00000004054.10 ENSMUST00000004054.11 ENSMUST00000004054.12 ENSMUST00000004054.2 ENSMUST00000004054.3 ENSMUST00000004054.4 ENSMUST00000004054.5 ENSMUST00000004054.6 ENSMUST00000004054.7 ENSMUST00000004054.8 ENSMUST00000004054.9 IMA5_MOUSE NM_008465 Q3TF32 Q60960 Rch2 uc007zcb.1 uc007zcb.2 uc007zcb.3 Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:8631802). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:8631802). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:8631802). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:8631802). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:8631802). Heterodimer; with KPNB1 (By similarity). Interacts with NSMF; the interaction occurs in a calcium-independent manner after synaptic NMDA receptor stimulation and is required for nuclear import of NSMF but is competed by CABP1 (By similarity). Interacts with APEX1 (via its N-terminus) (By similarity). Interacts with CTNNBL1 (via its N- terminal) (By similarity). Interacts with AICDA (via its NLS) (By similarity). Interacts with ANP32E (PubMed:10692581). Interacts with ZIC3 (PubMed:18716025). Interacts with SNAI1 (via zinc fingers) (By similarity). Interacts with DCAF8 (By similarity). Interacts with ITSN1 isoform 2 (PubMed:29599122). Interacts with TALDO1 isoform 1 (PubMed:27703206). Interacts with the AMPK-mediated 'Ser-659' phosphorylated form of ACSS2; this interaction results in nuclear translocation of ACSS2 (By similarity). Q60960; Q15637: SF1; Xeno; NbExp=3; IntAct=EBI-8573008, EBI-744603; Cytoplasm Nucleus Low levels in all tissues examined. Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C- terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import. The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity). The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity). Polyubiquitinated in the presence of RAG1 (in vitro). Belongs to the importin alpha family. protein binding nucleus nuclear pore nucleoplasm cytoplasm cytosol protein import into nucleus NLS-bearing protein import into nucleus nuclear localization sequence binding postsynaptic density protein transport dendrite nuclear import signal receptor activity glutamatergic synapse postsynapse to nucleus signaling pathway uc007zcb.1 uc007zcb.2 uc007zcb.3 
ENSMUST00000004055.10 Dzip1 ENSMUST00000004055.10 DAZ interacting protein 1, transcript variant 1 (from RefSeq NM_025943.3) DZIP1_MOUSE Dzip1 ENSMUST00000004055.1 ENSMUST00000004055.2 ENSMUST00000004055.3 ENSMUST00000004055.4 ENSMUST00000004055.5 ENSMUST00000004055.6 ENSMUST00000004055.7 ENSMUST00000004055.8 ENSMUST00000004055.9 Kiaa0996 NM_025943 Q4QQM0 Q6ZQ10 Q8BMD2 Q9CRK5 uc007uza.1 uc007uza.2 uc007uza.3 uc007uza.4 This gene encodes a zinc finger protein that has been demonstrated to interact with the deleted in azoospermia (DAZ) protein. DAZ plays an important role early in germ cell development to maintain the initial germ cell population. Deletion of this gene in mice compromises Hedgehog signaling during embryogenesis. Mouse embryos lacking the encoded protein show severe developmental defects with dorsalized neural tubes and underdeveloped somites. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 5. [provided by RefSeq, Jan 2015]. Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body (PubMed:23955340, PubMed:25860027, PubMed:31118289, PubMed:32051257). At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium (PubMed:25860027). Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium (PubMed:27979967). It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN (PubMed:23955340). Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm (PubMed:23955340). It is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum (PubMed:32051257). Also indirectly involved in heart development through its function in ciliogenesis (PubMed:31118289). Interacts with DAZ1 (By similarity). Interacts with the BBSome; recruits the BBSome to centriolar satellites of the cilium (PubMed:27979967). Interacts with PCM1; localizes DZIP1 and the associated BBSome to centriolar satellites (PubMed:27979967). Interacts with RAB8A (GDP-bound inactive form); recruits RAB8A to the basal body of the cilium and prevents its inhibition by GDI2 (PubMed:25860027). Interacts with GDI2; negatively regulates the interaction of GDI2 with GDP-bound RAB8A (PubMed:25860027). Interacts with GLI3; retains GLI3 within the cytoplasm (PubMed:23955340). Interacts with CEP164 (PubMed:23955340). Interacts with IFT88 (PubMed:23955340). Q8BMD2; Q61598: Gdi2; NbExp=2; IntAct=EBI-7089968, EBI-6665490; Q8BMD2; P55258: Rab8a; NbExp=2; IntAct=EBI-7089968, EBI-398411; Q8BMD2; P50395: GDI2; Xeno; NbExp=2; IntAct=EBI-7089968, EBI-1049143; Q8BMD2-1; P50395: GDI2; Xeno; NbExp=3; IntAct=EBI-16153101, EBI-1049143; Q8BMD2-1; P49841-2: GSK3B; Xeno; NbExp=3; IntAct=EBI-16153101, EBI-15870655; Q8BMD2-1; P61007: RAB8A; Xeno; NbExp=3; IntAct=EBI-16153101, EBI-7473289; Cytoplasm, cytoskeleton, cilium basal body toplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Nucleus Nucleus speckle Cytoplasm Note=Localizes to the centriole in cells lacking cilia and to the cilium basal body in ciliated cells (By similarity). At the exit of mitosis, when the primary cilium is reassembled in daughter cells, localizes at the mother centriole that acts as the basal body of the assembling primary cilium and also accumulates at the ciliary base that constitutes a diffusion barrier for ciliary proteins (PubMed:25860027). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BMD2-1; Sequence=Displayed; Name=2; IsoId=Q8BMD2-2; Sequence=VSP_010967, VSP_010968, VSP_010969; Name=3; IsoId=Q8BMD2-3; Sequence=VSP_010966; Expressed in testis and undifferentiated ES cells. Phosphorylation at Ser-210 by PLK1 before mitosis prevents interaction with PCM1 and localization to centriolar satellites. Thereby, it negatively regulates the localization of the BBSome to centriolar satellites (PubMed:27979967). Undergoes postmitotic phosphorylation at Ser-520 by GSK3B. That phosphorylated form of DZIP1 interacts with GDI2, disrupting its interaction with RAB8A, leading to RAB8A activation and localization to the cilium where it mediates protein transport and participates to cilium biogenesis (PubMed:25860027). Male animals were all infertile. Few spermatozoa were collected from the epididymides of the mutant, and no motile spermatozoa were seen. Light microscopy of the mutant spermatozoa showed severe morphologic abnormalities, primarily absent flagella as well as residual cytoplasm and abnormal heads. Belongs to the DZIP C2H2-type zinc-finger protein family. Sequence=BAC98066.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleic acid binding protein binding nucleus nucleoplasm cytoplasm centriole microtubule organizing center cytosol cytoskeleton cilium smoothened signaling pathway multicellular organism development germ cell development spermatogenesis cell differentiation ciliary basal body cell projection regulation of protein binding cilium organization establishment of protein localization positive regulation of cilium assembly metal ion binding cytoplasmic sequestering of protein cilium assembly protein localization to cilium ciliary transition fiber uc007uza.1 uc007uza.2 uc007uza.3 uc007uza.4 
ENSMUST00000004057.9 Fam162a ENSMUST00000004057.9 family with sequence similarity 162, member A (from RefSeq NM_027342.2) E2ig5 ENSMUST00000004057.1 ENSMUST00000004057.2 ENSMUST00000004057.3 ENSMUST00000004057.4 ENSMUST00000004057.5 ENSMUST00000004057.6 ENSMUST00000004057.7 ENSMUST00000004057.8 F162A_MOUSE NM_027342 Q9D6U8 uc007zcd.1 uc007zcd.2 uc007zcd.3 Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (PubMed:17316997). Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity (By similarity). Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permeability transition (By similarity). Mitochondrion membrane ; Single-pass membrane protein Induced by hypoxia. Belongs to the UPF0389 family. molecular_function mitochondrion cytosol apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process membrane integral component of membrane positive regulation of apoptotic process neuron apoptotic process cellular response to hypoxia positive regulation of release of cytochrome c from mitochondria uc007zcd.1 uc007zcd.2 uc007zcd.3 
ENSMUST00000004072.10 Rpl8 ENSMUST00000004072.10 ribosomal protein L8 (from RefSeq NM_012053.2) ENSMUST00000004072.1 ENSMUST00000004072.2 ENSMUST00000004072.3 ENSMUST00000004072.4 ENSMUST00000004072.5 ENSMUST00000004072.6 ENSMUST00000004072.7 ENSMUST00000004072.8 ENSMUST00000004072.9 NM_012053 P25120 P62918 Q3V288 RL8_MOUSE uc007wmt.1 uc007wmt.2 uc007wmt.3 uc007wmt.4 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit (PubMed:36517592). Interacts with CRY1 (PubMed:19129230). Cytoplasm Hydroxylated on His-216 by RIOX1. The modification is impaired by hypoxia. Belongs to the universal ribosomal protein uL2 family. cytoplasmic translation RNA binding structural constituent of ribosome protein binding cytoplasm ribosome translation postsynaptic density large ribosomal subunit rRNA binding cytosolic large ribosomal subunit polysomal ribosome synapse postsynapse uc007wmt.1 uc007wmt.2 uc007wmt.3 uc007wmt.4 
ENSMUST00000004076.5 Grm3 ENSMUST00000004076.5 glutamate receptor, metabotropic 3, transcript variant 1 (from RefSeq NM_181850.3) ENSMUST00000004076.1 ENSMUST00000004076.2 ENSMUST00000004076.3 ENSMUST00000004076.4 GRM3_MOUSE Gprc1c Mglur3 NM_181850 Q14DJ9 Q9QYS2 uc008wll.1 uc008wll.2 uc008wll.3 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. Interacts with TAMALIN. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 3 family. group II metabotropic glutamate receptor activity G-protein coupled receptor activity calcium channel regulator activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway glutamate receptor activity postsynaptic density membrane integral component of membrane sensory perception of pain axon synaptic transmission, glutamatergic presynaptic membrane neuron projection dendritic spine postsynaptic membrane presynaptic active zone modulation of synaptic transmission regulation of sensory perception of pain regulation of synaptic transmission, glutamatergic astrocyte projection glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane uc008wll.1 uc008wll.2 uc008wll.3 
ENSMUST00000004094.15 Ssbp2 ENSMUST00000004094.15 single-stranded DNA binding protein 2, transcript variant 2 (from RefSeq NM_024272.5) B1B188 ENSMUST00000004094.1 ENSMUST00000004094.10 ENSMUST00000004094.11 ENSMUST00000004094.12 ENSMUST00000004094.13 ENSMUST00000004094.14 ENSMUST00000004094.2 ENSMUST00000004094.3 ENSMUST00000004094.4 ENSMUST00000004094.5 ENSMUST00000004094.6 ENSMUST00000004094.7 ENSMUST00000004094.8 ENSMUST00000004094.9 NM_024272 Q99LX9 Q9CYZ8 SSBP2_MOUSE Ssdp2 uc007rjv.1 uc007rjv.2 uc007rjv.3 uc007rjv.4 Q9CYZ8; Q9WUH2: Lhx9; NbExp=3; IntAct=EBI-309962, EBI-309943; Q9CYZ8; Q60769: Tnfaip3; NbExp=2; IntAct=EBI-309962, EBI-646595; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CYZ8-1; Sequence=Displayed; Name=2; IsoId=Q9CYZ8-2; Sequence=VSP_006259; DNA binding single-stranded DNA binding protein binding nucleus cytoplasm positive regulation of transcription from RNA polymerase II promoter uc007rjv.1 uc007rjv.2 uc007rjv.3 uc007rjv.4 
ENSMUST00000004120.9 Fancl ENSMUST00000004120.9 Fanconi anemia, complementation group L, transcript variant 3 (from RefSeq NR_102382.1) ENSMUST00000004120.1 ENSMUST00000004120.2 ENSMUST00000004120.3 ENSMUST00000004120.4 ENSMUST00000004120.5 ENSMUST00000004120.6 ENSMUST00000004120.7 ENSMUST00000004120.8 FANCL_MOUSE NR_102382 Phf9 Pog Q3TGY2 Q9CR14 Q9D017 uc007ige.1 uc007ige.2 uc007ige.3 uc007ige.4 This gene encodes the complementation group L subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes. The FA complex is necessary for protection against DNA damage. This gene product, an E3 ubiquitin ligase, catalyzes and is required for the monoubiquitination of the protein encoded by the Fanconi anemia, complementation group D2 gene, a critical step in the FA pathway (PMID: 12973351, 21229326). In mouse, mutations of this E3 ubiquitin ligase gene can lead to infertility in adult males and females, and a deletion of this gene can cause embryonic lethality in some genetic backgrounds. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM (By similarity). In complex with FANCF, FANCA and FANCG, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins. Interacts with FANCI (By similarity). Interacts with GGN. Interacts (via the RING-type zinc finger) with UBE2T and UBE2W. Cytoplasm Nucleus Note=In the nucleus, colocalizes with UBE2W. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CR14-1; Sequence=Displayed; Name=2; IsoId=Q9CR14-2; Sequence=VSP_008552; The UBC-RWD region (URD) region mediates interaction with FANCI and FANCD2. The RING-type zinc finger domain is monoubiquitinated in the presence of UBE2T and UBE2W. Note=Defects in Fancl are a cause of the gcd (germ cell deficient) mutant phenotype, which leads to reduced numbers of precursor germ cells and adult sterility, probably due to a reduced precursor germ cells proliferation. Despite its name, it does not contain a PHD-type zinc finger, but contains a RING-type zinc finger. Moreover, PHD-type zinc fingers do not have any ubiquitin ligase activity. ubiquitin-protein transferase activity protein binding nucleus nuclear envelope cytoplasm DNA repair protein monoubiquitination cellular response to DNA damage stimulus gamete generation protein ubiquitination nuclear body transferase activity ubiquitin protein ligase binding interstrand cross-link repair regulation of cell proliferation intracellular membrane-bounded organelle Fanconi anaemia nuclear complex metal ion binding ubiquitin protein ligase activity uc007ige.1 uc007ige.2 uc007ige.3 uc007ige.4 
ENSMUST00000004133.11 Brinp2 ENSMUST00000004133.11 bone morphogenic protein/retinoic acid inducible neural-specific 2 (from RefSeq NM_207583.2) BRNP2_MOUSE ENSMUST00000004133.1 ENSMUST00000004133.10 ENSMUST00000004133.2 ENSMUST00000004133.3 ENSMUST00000004133.4 ENSMUST00000004133.5 ENSMUST00000004133.6 ENSMUST00000004133.7 ENSMUST00000004133.8 ENSMUST00000004133.9 Fam5b Kiaa1747 NM_207583 Q6DFY8 Q80T96 uc007ddq.1 uc007ddq.2 uc007ddq.3 uc007ddq.4 Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Secreted Weakly expressed in embryonic stem (ES) cells. Strongly expressed in ES-derived neural stem cells (NSCs). Up-regulated upon differentiation into neuronal cells in the presence of retinoic acid and BDNF. Down-regulated upon differentiation into astroglial cells. Belongs to the BRINP family. Sequence=BAC65831.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function extracellular region endoplasmic reticulum cell cycle cell cycle arrest dendrite neuronal cell body positive regulation of neuron differentiation negative regulation of cell cycle negative regulation of mitotic cell cycle cellular response to retinoic acid uc007ddq.1 uc007ddq.2 uc007ddq.3 uc007ddq.4 
ENSMUST00000004134.11 Gstm5 ENSMUST00000004134.11 glutathione S-transferase, mu 5 (from RefSeq NM_010360.3) ENSMUST00000004134.1 ENSMUST00000004134.10 ENSMUST00000004134.2 ENSMUST00000004134.3 ENSMUST00000004134.4 ENSMUST00000004134.5 ENSMUST00000004134.6 ENSMUST00000004134.7 ENSMUST00000004134.8 ENSMUST00000004134.9 Fsc2 GSTM5_MOUSE Gstm3 NM_010360 P48774 Q545W5 uc008qxs.1 uc008qxs.2 uc008qxs.3 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Homodimer (By similarity). Interacts with PFKM isoform 2 and isoform 3 (via N-terminal testis-specific region) (PubMed:19889946). Cytoplasm. Belongs to the GST superfamily. Mu family. glutathione transferase activity protein binding cytoplasm cytosol glutathione metabolic process transferase activity nitrobenzene metabolic process enzyme binding sperm fibrous sheath xenobiotic catabolic process identical protein binding protein homodimerization activity glutathione binding response to estrogen intercellular bridge cellular detoxification of nitrogen compound uc008qxs.1 uc008qxs.2 uc008qxs.3 
ENSMUST00000004136.10 Gstm3 ENSMUST00000004136.10 glutathione S-transferase, mu 3 (from RefSeq NM_010359.3) ENSMUST00000004136.1 ENSMUST00000004136.2 ENSMUST00000004136.3 ENSMUST00000004136.4 ENSMUST00000004136.5 ENSMUST00000004136.6 ENSMUST00000004136.7 ENSMUST00000004136.8 ENSMUST00000004136.9 GSTM3_MOUSE NM_010359 P19639 uc008qxv.1 uc008qxv.2 uc008qxv.3 uc008qxv.4 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Homodimer. Cytoplasm. Belongs to the GST superfamily. Mu family. Sequence=AAA37748.1; Type=Erroneous initiation; Evidence=; glutathione transferase activity cytoplasm glutathione metabolic process response to bacterium transferase activity cellular response to drug protein homodimerization activity cellular response to organic cyclic compound uc008qxv.1 uc008qxv.2 uc008qxv.3 uc008qxv.4 
ENSMUST00000004137.11 Gstm7 ENSMUST00000004137.11 glutathione S-transferase, mu 7, transcript variant 1 (from RefSeq NM_026672.3) ENSMUST00000004137.1 ENSMUST00000004137.10 ENSMUST00000004137.2 ENSMUST00000004137.3 ENSMUST00000004137.4 ENSMUST00000004137.5 ENSMUST00000004137.6 ENSMUST00000004137.7 ENSMUST00000004137.8 ENSMUST00000004137.9 GSTM7_MOUSE NM_026672 Q3TRV7 Q3V4E2 Q80W21 uc008qxt.1 uc008qxt.2 uc008qxt.3 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Homodimer. Cytoplasm Belongs to the GST superfamily. Mu family. Gstm7 is the putative homolog of human GSTM2. glutathione transferase activity glutathione peroxidase activity receptor binding cytoplasm cytosol glutathione metabolic process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum sarcoplasmic reticulum transferase activity nitrobenzene metabolic process enzyme binding xenobiotic catabolic process protein homodimerization activity glutathione binding linoleic acid metabolic process intercellular bridge negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity cellular detoxification of nitrogen compound cellular response to caffeine cellular oxidant detoxification uc008qxt.1 uc008qxt.2 uc008qxt.3 
ENSMUST00000004140.11 Gstm1 ENSMUST00000004140.11 glutathione S-transferase, mu 1, transcript variant 2 (from RefSeq NM_010358.5) A2AE90 ENSMUST00000004140.1 ENSMUST00000004140.10 ENSMUST00000004140.2 ENSMUST00000004140.3 ENSMUST00000004140.4 ENSMUST00000004140.5 ENSMUST00000004140.6 ENSMUST00000004140.7 ENSMUST00000004140.8 ENSMUST00000004140.9 GSTM1_MOUSE Gstm1 NM_010358 P10649 Q58ET5 uc008qxx.1 uc008qxx.2 uc008qxx.3 uc008qxx.4 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16438; Evidence=; Reaction=glutathione + prostaglandin A2 = prostaglandin A2-S-(R)- glutathione; Xref=Rhea:RHEA:50796, ChEBI:CHEBI:57925, ChEBI:CHEBI:133370, ChEBI:CHEBI:133768; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50797; Evidence=; Reaction=glutathione + prostaglandin J2 = prostaglandin J2-S-(R)- glutathione; Xref=Rhea:RHEA:50804, ChEBI:CHEBI:57925, ChEBI:CHEBI:133396, ChEBI:CHEBI:133771; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50805; Evidence=; Reaction=glutathione + prostaglandin J2 = prostaglandin J2-S-(S)- glutathione; Xref=Rhea:RHEA:50808, ChEBI:CHEBI:57925, ChEBI:CHEBI:133396, ChEBI:CHEBI:133772; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50809; Evidence=; Reaction=glutathione + prostaglandin A2 = prostaglandin A2-S-(S)- glutathione; Xref=Rhea:RHEA:50800, ChEBI:CHEBI:57925, ChEBI:CHEBI:133370, ChEBI:CHEBI:133769; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50801; Evidence=; Reaction=11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)- eicosatrienoate; Xref=Rhea:RHEA:50260, ChEBI:CHEBI:57925, ChEBI:CHEBI:132200, ChEBI:CHEBI:132201; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50261; Evidence=; Homodimer. Cytoplasm. Mass=25838.4; Mass_error=2; Method=Electrospray; Evidence=; Belongs to the GST superfamily. Mu family. glutathione transferase activity steroid binding protein binding extracellular region cytoplasm cytosol glutathione metabolic process nickel cation binding transferase activity protein kinase binding macromolecular complex cellular response to drug xenobiotic catabolic process identical protein binding protein homodimerization activity myelin sheath glutathione binding intercellular bridge uc008qxx.1 uc008qxx.2 uc008qxx.3 uc008qxx.4 
ENSMUST00000004143.3 Stat5b ENSMUST00000004143.3 signal transducer and activator of transcription 5B, transcript variant 3 (from RefSeq NM_001362682.1) A2A5D5 ENSMUST00000004143.1 ENSMUST00000004143.2 NM_001362682 P42232 Q541Q5 Q60804 Q8K3Q1 Q9JKM1 Q9R0X8 STA5B_MOUSE uc007lmj.1 uc007lmj.2 uc007lmj.3 uc007lmj.4 Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. Upon activation, forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (PubMed:9528750). Interacts with NCOA1 (By similarity). Interacts with SOCS7 (By similarity). Interacts (via SH2 domain) with INSR (PubMed:9428692). Interacts with CPEB3; this inhibits STAT5B-mediated transcriptional activation (PubMed:20639532). P42232; Q96EY1: DNAJA3; Xeno; NbExp=3; IntAct=EBI-617454, EBI-356767; P42232; Q96EY1-1: DNAJA3; Xeno; NbExp=2; IntAct=EBI-617454, EBI-4322330; P42232; Q96EY1-2: DNAJA3; Xeno; NbExp=2; IntAct=EBI-617454, EBI-3952284; P42232; P19941: GHR; Xeno; NbExp=6; IntAct=EBI-617454, EBI-7526279; Cytoplasm Nucleus Note=Translocated into the nucleus in response to phosphorylation. In the virgin, found in most tissues. Particularly abundant in muscle tissue of virgin and lactating females, and of males. Detected both in virgin mouse and after mammary gland involution. The level of STAT5A increases constantly during pregnancy, but decreases during lactation. Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 (By similarity). Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity (By similarity). Belongs to the transcription factor STAT family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding luteinization natural killer cell differentiation liver development DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter defense response acute-phase response signal transduction JAK-STAT cascade sex differentiation female pregnancy lactation positive regulation of cell proliferation regulation of steroid metabolic process cytokine-mediated signaling pathway taurine metabolic process lipid storage regulation of cell adhesion regulation of epithelial cell differentiation response to estradiol response to lipopolysaccharide positive regulation of natural killer cell proliferation positive regulation of natural killer cell differentiation cellular response to hormone stimulus T cell differentiation in thymus glucocorticoid receptor binding regulation of multicellular organism growth positive regulation of multicellular organism growth positive regulation of activated T cell proliferation regulation of cell proliferation progesterone metabolic process T cell homeostasis negative regulation of apoptotic process response to peptide hormone sequence-specific DNA binding positive regulation of interleukin-2 biosynthetic process positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of lymphocyte differentiation negative regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of natural killer cell mediated cytotoxicity development of secondary female sexual characteristics development of secondary male sexual characteristics protein dimerization activity Peyer's patch development positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response positive regulation of cellular component movement JAK-STAT cascade involved in growth hormone signaling pathway response to interleukin-2 response to interleukin-4 response to interleukin-15 cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus mast cell migration uc007lmj.1 uc007lmj.2 uc007lmj.3 uc007lmj.4 
ENSMUST00000004145.14 Stat5a ENSMUST00000004145.14 signal transducer and activator of transcription 5A, transcript variant 1 (from RefSeq NM_011488.3) ENSMUST00000004145.1 ENSMUST00000004145.10 ENSMUST00000004145.11 ENSMUST00000004145.12 ENSMUST00000004145.13 ENSMUST00000004145.2 ENSMUST00000004145.3 ENSMUST00000004145.4 ENSMUST00000004145.5 ENSMUST00000004145.6 ENSMUST00000004145.7 ENSMUST00000004145.8 ENSMUST00000004145.9 NM_011488 Q9JIA0 Q9JIA0_MOUSE Stat5A Stat5a uc007lml.1 uc007lml.2 uc007lml.3 Cytoplasm cleus Belongs to the transcription factor STAT family. transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated signal transduction positive regulation of transcription from RNA polymerase II promoter JAK-STAT cascade involved in growth hormone signaling pathway uc007lml.1 uc007lml.2 uc007lml.3 
ENSMUST00000004156.10 Map3k11 ENSMUST00000004156.10 mitogen-activated protein kinase kinase kinase 11, transcript variant 1 (from RefSeq NM_022012.4) ENSMUST00000004156.1 ENSMUST00000004156.2 ENSMUST00000004156.3 ENSMUST00000004156.4 ENSMUST00000004156.5 ENSMUST00000004156.6 ENSMUST00000004156.7 ENSMUST00000004156.8 ENSMUST00000004156.9 M3K11_MOUSE Mlk3 NM_022012 Q80XI6 Q8K0M8 Q9JJ15 uc008get.1 uc008get.2 uc008get.3 uc008get.4 uc008get.5 Activates the JUN N-terminal pathway. Required for serum- stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen- stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation. Homodimer; undergoes dimerization during activation. Interacts with MAP2K4/MKK4 and MAP2K7/MKK7 (By similarity). Found in a complex with SH3RF1, RAC1, MAP2K7/MKK7, MAPK8IP1/JIP1 and MAPK8/JNK1 (PubMed:23963642). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Location is cell cycle dependent. Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-278 is likely to be the main autophosphorylation site. Phosphorylation of Ser-556 and Ser-557 is induced by CDC42 (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. nucleotide binding activation of MAPK activity protein kinase activity protein serine/threonine kinase activity JUN kinase kinase kinase activity MAP kinase kinase kinase activity protein binding ATP binding cytoplasm centrosome microtubule organizing center cytoskeleton microtubule protein phosphorylation microtubule-based process JNK cascade activation of JNKK activity activation of JUN kinase activity cell death cell proliferation kinase activity phosphorylation transferase activity mitogen-activated protein kinase kinase binding mitogen-activated protein kinase kinase kinase binding identical protein binding protein homodimerization activity positive regulation of apoptotic process positive regulation of JUN kinase activity positive regulation of neuron apoptotic process positive regulation of JNK cascade protein autophosphorylation Rac GTPase binding uc008get.1 uc008get.2 uc008get.3 uc008get.4 uc008get.5 
ENSMUST00000004172.15 Hmox2 ENSMUST00000004172.15 heme oxygenase 2, transcript variant 1 (from RefSeq NM_001136066.2) ENSMUST00000004172.1 ENSMUST00000004172.10 ENSMUST00000004172.11 ENSMUST00000004172.12 ENSMUST00000004172.13 ENSMUST00000004172.14 ENSMUST00000004172.2 ENSMUST00000004172.3 ENSMUST00000004172.4 ENSMUST00000004172.5 ENSMUST00000004172.6 ENSMUST00000004172.7 ENSMUST00000004172.8 ENSMUST00000004172.9 Hmox2 NM_001136066 Q544R7 Q544R7_MOUSE uc007yag.1 uc007yag.2 uc007yag.3 uc007yag.4 Reaction=heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:21764, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17245, ChEBI:CHEBI:29033, ChEBI:CHEBI:57618, ChEBI:CHEBI:57991, ChEBI:CHEBI:58210, ChEBI:CHEBI:60344; EC=1.14.14.18; Evidence=; Belongs to the heme oxygenase family. heme oxygenase (decyclizing) activity heme oxidation response to oxidative stress membrane integral component of membrane metal ion binding oxidation-reduction process uc007yag.1 uc007yag.2 uc007yag.3 uc007yag.4 
ENSMUST00000004173.12 Cdip1 ENSMUST00000004173.12 cell death inducing Trp53 target 1, transcript variant 6 (from RefSeq NM_025670.5) CDIP1_MOUSE ENSMUST00000004173.1 ENSMUST00000004173.10 ENSMUST00000004173.11 ENSMUST00000004173.2 ENSMUST00000004173.3 ENSMUST00000004173.4 ENSMUST00000004173.5 ENSMUST00000004173.6 ENSMUST00000004173.7 ENSMUST00000004173.8 ENSMUST00000004173.9 NM_025670 Q3UD73 Q9CYP1 Q9DB75 uc007yaj.1 uc007yaj.2 uc007yaj.3 Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner (By similarity). Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DB75-1; Sequence=Displayed; Name=2; IsoId=Q9DB75-2; Sequence=VSP_023632; The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes. Belongs to the CDIP1/LITAF family. nucleus lysosome lysosomal membrane endosome apoptotic process membrane late endosome membrane tumor necrosis factor-mediated signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator metal ion binding cytoplasmic side of late endosome membrane cytoplasmic side of lysosomal membrane uc007yaj.1 uc007yaj.2 uc007yaj.3 
ENSMUST00000004200.9 Cwc15 ENSMUST00000004200.9 CWC15 spliceosome-associated protein (from RefSeq NM_023153.3) CWC15_MOUSE ENSMUST00000004200.1 ENSMUST00000004200.2 ENSMUST00000004200.3 ENSMUST00000004200.4 ENSMUST00000004200.5 ENSMUST00000004200.6 ENSMUST00000004200.7 ENSMUST00000004200.8 Ed1 NM_023153 Q3TH98 Q9CTH0 Q9JHS9 uc009oeo.1 uc009oeo.2 uc009oeo.3 Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CTNNBL1 in the complex. Component of the minor spliceosome, which splices U12-type introns (By similarity). Nucleus Belongs to the CWC15 family. mRNA splicing, via spliceosome RNA binding nucleus spliceosomal complex mitochondrion mRNA processing RNA splicing nuclear speck mRNA cis splicing, via spliceosome U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome uc009oeo.1 uc009oeo.2 uc009oeo.3 
ENSMUST00000004201.8 Col5a3 ENSMUST00000004201.8 collagen, type V, alpha 3, transcript variant 1 (from RefSeq NM_016919.3) Col5a3 ENSMUST00000004201.1 ENSMUST00000004201.2 ENSMUST00000004201.3 ENSMUST00000004201.4 ENSMUST00000004201.5 ENSMUST00000004201.6 ENSMUST00000004201.7 NM_016919 Q9JLI2 Q9JLI2_MOUSE uc009ojf.1 uc009ojf.2 uc009ojf.3 uc009ojf.4 Type I collagen is a member of group I collagen (fibrillar forming collagen). Trimers of one alpha 2(I) and two alpha 1(I) chains. Belongs to the fibrillar collagen family. Lacks conserved residue(s) required for the propagation of feature annotation. structural molecule activity extracellular matrix structural constituent collagen trimer collagen type V trimer collagen type IX trimer extracellular space cell-matrix adhesion heparin binding extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix proteoglycan binding uc009ojf.1 uc009ojf.2 uc009ojf.3 uc009ojf.4 
ENSMUST00000004202.17 Dnmt1 ENSMUST00000004202.17 DNA methyltransferase 1, transcript variant 2 (from RefSeq NM_010066.5) DNMT1_MOUSE Dnmt ENSMUST00000004202.1 ENSMUST00000004202.10 ENSMUST00000004202.11 ENSMUST00000004202.12 ENSMUST00000004202.13 ENSMUST00000004202.14 ENSMUST00000004202.15 ENSMUST00000004202.16 ENSMUST00000004202.2 ENSMUST00000004202.3 ENSMUST00000004202.4 ENSMUST00000004202.5 ENSMUST00000004202.6 ENSMUST00000004202.7 ENSMUST00000004202.8 ENSMUST00000004202.9 Met1 NM_010066 P13864 P97413 Q80ZU3 Q9CSC6 Q9QXX6 Uim uc009ojq.1 uc009ojq.2 uc009ojq.3 uc009ojq.4 This gene encodes a methyltransferase that preferentially methylates cytosines of CpG residues in hemimethylated DNA to generate fully methylated CpG base pairs during DNA replication. This enzyme plays roles in diverse cellular processes including cell cycle regulation, DNA repair, and telomere maintenance. The encoded protein is composed of an N-terminal domain with a nuclear localization sequence and replication fork-targeting domain, a DNA-binding CXXC domain, two bromo-adjacent homology domains, and a C-terminal catalytic domain. Mouse embryonic stem cells mutant for this gene are viable, but when introduced into the germ line, cause a recessive lethal phenotype with mutant embryos displaying stunted growth and developmental defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS- mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (By similarity). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (By similarity). Promotes tumor growth (By similarity). Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5- methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37; Evidence=; Allosterically regulated. The binding of 5- methylcytosine-containing DNA to the N-terminal parts of DNMT1 causes an allosteric activation of the catalytic domain by a direct interaction of its Zn-binding domain with the catalytic domain. Homodimer (By similarity). Forms a stable complex with E2F1, BB1 and HDAC1 (By similarity). Forms a complex with DMAP1 and HDAC2, with direct interaction (PubMed:10888872). Interacts with the PRC2/EED- EZH2 complex (PubMed:16357870). Probably part of a corepressor complex containing ZNF304, TRIM28, SETDB1 and DNMT1 (By similarity). Interacts with UHRF1; promoting its recruitment to hemimethylated DNA (PubMed:21268065). Interacts with USP7, promoting its deubiquitination (PubMed:21268065). Interacts with BAZ2A/TIP5 (PubMed:16085498). Interacts with PCNA (By similarity). Interacts with MBD2 and MBD3 (By similarity). Interacts with DNMT3A and DNMT3B (By similarity). Interacts with UBC9 (By similarity). Interacts with HDAC1 (PubMed:10615135). Interacts with CSNK1D (PubMed:20192920). Interacts with SIRT7 (PubMed:28842251). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (By similarity). Interacts with L3MBTL3 and DCAF5; the interaction requires DNMT1 methylation at Lys-139 and is necessary to target DNMT1 for ubiquitination by the CRL4-DCAF5 E3 ubiquitin ligase complex and proteasomal degradation (By similarity). Interacts with PHF20L1; the interaction requires DNMT1 methylation at Lys-139 and protects DNMT1 from ubiquitination and proteasomal degradation (By similarity). P13864; O09106: Hdac1; NbExp=3; IntAct=EBI-301927, EBI-301912; Nucleus Cytoplasm Note=It is nucleoplasmic through most of the cell cycle and associates with replication foci during S-phase. In germ cells, spermatogonia, preleptotene and leptotene spermatocytes all express high levels of nuclear protein, while the protein is not detected in pachytene spermatocytes, despite the fact they expressed high levels of mRNA. In females, the protein is not detected in non- growing oocytes, in contrast to the growing oocytes. During the growing, the protein is no longer detectable in nuclei but accumulates to very high levels first throughout the cytoplasm. At the time of ovulation, all the protein is cytoplasmic and is actively associated with the oocyte cortex. After fecondation, in the preimplantation embryo, the protein remains cytoplasmic and after implantation, it is exclusively nuclear in all tissue types. Isoform 2 is sequestered in the cytoplasm of maturing oocytes and of preimplantation embryos, except for the 8-cell stage, while isoform 1 is exclusively nuclear. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=P13864-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P13864-2; Sequence=VSP_005619; Isoform 1 is expressed in embryonic stem cells and in somatic tissues. Isoform 2 is expressed in oocytes, preimplantation embryos, testis and in skeletal muscle during myogenesis. In germ cells, it is present at high levels in spermatogonia and spermatocytes until the pachytene stage, where it falls to undetectable levels. The transient drop at the pachytene stage coincides with the disappearance of the 5.2 kb mRNA and the accumulation of a larger 6.0 kb mRNA. Oocytes accumulate very large amounts of Dnmt1 protein during the growth phase. The N-terminal part is required for homodimerization and acts as a regulatory domain. The CXXC-type zinc finger specifically binds to unmethylated CpG dinucleotides, positioning the autoinhibitory linker between the DNA and the active site, thus providing a mechanism to ensure that only hemimethylated CpG dinucleotides undergo methylation. Sumoylated; sumoylation increases activity. Phosphorylation at Ser-146 by CK1 reduces DNA-binding activity. Acetylation on multiple lysines, mainly by KAT2B/PCAF, regulates cell cycle G(2)/M transition. Deacetylation of Lys-1352 and Lys-1418 by SIRT1 increases methyltransferase activity. Phosphorylation of Ser-152 by CDKs is important for enzymatic activity and protein stability. Phosphorylation of Ser-140 by AKT1 prevents methylation by SETD7 therebye increasing DNMT1 stability. Methylation at Lys-139 by SETD7 is necessary for the regulation of DNMT1 proteasomal degradation. Ubiquitinated by UHRF1; interaction with USP7 counteracts ubiquitination by UHRF1 by promoting deubiquitination and preventing degradation by the proteasome. There are three 5' exons, one specific to the oocyte (1c), one specific to the pachytene spermatocyte and also found in skeletal muscle (1b) and one found in somatic cells (1a). Three different mRNAs can be produced which give rise to two different translation products: isoform 1 (mRNAs-1a) and isoform 2 (mRNA-1b or -1c). Association of DNMT1 with the replication machinery is not strictly required for maintaining global methylation but still enhances methylation efficiency by 2-fold. Pre-existing cytosine methylation at CpG and non-CpG sites enhances methylation activity. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. Sequence=AAC52900.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter heterochromatin DNA binding chromatin binding RNA binding catalytic activity DNA (cytosine-5-)-methyltransferase activity protein binding nucleus nucleoplasm replication fork pericentric heterochromatin cytoplasm DNA methylation chromatin organization Ras protein signal transduction metabolic process methyltransferase activity zinc ion binding methyl-CpG binding DNA-methyltransferase activity maintenance of DNA methylation DNA methylation on cytosine within a CG sequence regulation of gene expression positive regulation of gene expression negative regulation of gene expression gene silencing transferase activity protein domain specific binding estrogen receptor binding methylation DNA methylation on cytosine macromolecular complex regulation of cell proliferation response to drug histone deacetylase binding neuronal cell body DNA methylation involved in embryo development DNA hypermethylation negative regulation of transcription, DNA-templated S-adenosylmethionine metabolic process metal ion binding positive regulation of histone H3-K4 methylation negative regulation of histone H3-K9 methylation DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates cellular response to amino acid stimulus cellular response to transforming growth factor beta stimulus C-5 methylation of cytosine positive regulation of methylation-dependent chromatin silencing positive regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell apoptotic process promoter-specific chromatin binding uc009ojq.1 uc009ojq.2 uc009ojq.3 uc009ojq.4 
ENSMUST00000004203.6 Ppan ENSMUST00000004203.6 peter pan homolog (from RefSeq NM_145610.2) ENSMUST00000004203.1 ENSMUST00000004203.2 ENSMUST00000004203.3 ENSMUST00000004203.4 ENSMUST00000004203.5 NM_145610 Q8BYM4 Q91YU8 SSF1_MOUSE Ssf1 uc009ojk.1 uc009ojk.2 uc009ojk.3 uc009ojk.4 May have a role in cell growth. Nucleus, nucleolus ribosomal large subunit assembly regulation of cell growth by extracellular stimulus nucleus nucleolus preribosome, large subunit precursor uc009ojk.1 uc009ojk.2 uc009ojk.3 uc009ojk.4 
ENSMUST00000004206.10 Eif3g ENSMUST00000004206.10 eukaryotic translation initiation factor 3, subunit G (from RefSeq NM_016876.3) EIF3G_MOUSE ENSMUST00000004206.1 ENSMUST00000004206.2 ENSMUST00000004206.3 ENSMUST00000004206.4 ENSMUST00000004206.5 ENSMUST00000004206.6 ENSMUST00000004206.7 ENSMUST00000004206.8 ENSMUST00000004206.9 Eif3p42 Eif3s4 NM_016876 Q9R079 Q9Z1D1 uc009ojm.1 uc009ojm.2 uc009ojm.3 RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus) (By similarity). Interacts with DHX33; the interaction is independent of RNA (PubMed:26100019). Cytoplasm Nucleus Cytoplasm, perinuclear region Note=Colocalizes with AIFM1 in the nucleus and perinuclear region. Phosphorylated. Phosphorylation is enhanced upon serum stimulation. Belongs to the eIF-3 subunit G family. formation of cytoplasmic translation initiation complex cytoplasmic translational initiation nucleic acid binding RNA binding translation initiation factor activity protein binding nucleus cytoplasm cytosol eukaryotic translation initiation factor 3 complex translation translational initiation eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex perinuclear region of cytoplasm viral translational termination-reinitiation uc009ojm.1 uc009ojm.2 uc009ojm.3 
ENSMUST00000004208.7 Angptl2 ENSMUST00000004208.7 angiopoietin-like 2 (from RefSeq NM_011923.4) ANGL2_MOUSE Arp2 ENSMUST00000004208.1 ENSMUST00000004208.2 ENSMUST00000004208.3 ENSMUST00000004208.4 ENSMUST00000004208.5 ENSMUST00000004208.6 NM_011923 Q8BM09 Q9R045 uc008jhr.1 uc008jhr.2 uc008jhr.3 Induces sprouting in endothelial cells through an autocrine and paracrine action. Secreted Widely expressed in heart, tongue, lung and skeletal muscle. Also found in lower levels in kidney, epididymis and testis. extracellular region extracellular space uc008jhr.1 uc008jhr.2 uc008jhr.3 
ENSMUST00000004222.14 Hira ENSMUST00000004222.14 histone cell cycle regulator (from RefSeq NM_010435.2) ENSMUST00000004222.1 ENSMUST00000004222.10 ENSMUST00000004222.11 ENSMUST00000004222.12 ENSMUST00000004222.13 ENSMUST00000004222.2 ENSMUST00000004222.3 ENSMUST00000004222.4 ENSMUST00000004222.5 ENSMUST00000004222.6 ENSMUST00000004222.7 ENSMUST00000004222.8 ENSMUST00000004222.9 HIRA_MOUSE NM_010435 O08845 Q3TFY0 Q3UX35 Q61666 Q62365 Q7TMW4 Tuple1 uc007yoq.1 uc007yoq.2 uc007yoq.3 uc007yoq.4 Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Interacts with CCNA1, HIRIP3 and NFU1/HIRIP5 (By similarity). Part of a complex which includes ASF1A, CABIN1, histone H3.3, histone H4 and UBN1 (By similarity). Interacts with histone H2B, histone H3-3B, PAX3 and PAX7 (PubMed:9731536). Nucleus Nucleus, PML body Note=Primarily, though not exclusively, localized to the nucleus (By similarity). Localizes to PML bodies immediately prior to onset of senescence (By similarity). Localizes specifically to the male nucleus in fertilized eggs. This localization persists from the initiation of sperm nucleus decondensation to pronucleus formation. Event=Alternative splicing; Named isoforms=4; Name=Long; IsoId=Q61666-1; Sequence=Displayed; Name=Short; IsoId=Q61666-2; Sequence=VSP_006773, VSP_006774; Name=3; IsoId=Q61666-3; Sequence=VSP_025050, VSP_025051, VSP_025052; Name=4; IsoId=Q61666-4; Sequence=VSP_025049; Expressed in cerebrum, cerebellum, heart, kidney, liver, lung and spleen. Throughout development the long isoform is more abundant. In embryos, ubiquitously expressed with high levels detected in cranial neural folds, subregions of pharyngeal arches 1 and 2, circumpharyngeal neural crest and limb buds. Sumoylated. Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-554 in vitro (By similarity). Also phosphorylated on Thr-554 in vivo. Embryonic stem cells (ES cells) exhibit accelerated differentiation in the early stages which may be attributable to increased availability of soluble histones. Belongs to the WD repeat HIR1 family. mitotic sister chromatid segregation HIR complex chromosome, centromeric region nuclear chromatin osteoblast differentiation transcription corepressor activity protein binding nucleus chromatin organization DNA replication-independent nucleosome assembly transcription, DNA-templated regulation of transcription, DNA-templated gastrulation PML body chromatin silencing at centromere regulation of chromatin silencing macromolecular complex muscle cell differentiation DNA binding nucleosome binding uc007yoq.1 uc007yoq.2 uc007yoq.3 uc007yoq.4 
ENSMUST00000004232.10 Adh1 ENSMUST00000004232.10 alcohol dehydrogenase 1 (class I) (from RefSeq NM_007409.3) Adh1 ENSMUST00000004232.1 ENSMUST00000004232.2 ENSMUST00000004232.3 ENSMUST00000004232.4 ENSMUST00000004232.5 ENSMUST00000004232.6 ENSMUST00000004232.7 ENSMUST00000004232.8 ENSMUST00000004232.9 NM_007409 Q3UKA4 Q3UKA4_MOUSE uc008rnf.1 uc008rnf.2 uc008rnf.3 Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH; Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; Evidence=; Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH; Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Cytoplasm Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. zinc ion binding oxidoreductase activity metal ion binding oxidation-reduction process uc008rnf.1 uc008rnf.2 uc008rnf.3 
ENSMUST00000004281.10 Dyrk2 ENSMUST00000004281.10 dual-specificity tyrosine phosphorylation regulated kinase 2 (from RefSeq NM_001014390.2) DYRK2_MOUSE Dyrk2 ENSMUST00000004281.1 ENSMUST00000004281.2 ENSMUST00000004281.3 ENSMUST00000004281.4 ENSMUST00000004281.5 ENSMUST00000004281.6 ENSMUST00000004281.7 ENSMUST00000004281.8 ENSMUST00000004281.9 NM_001014390 Q5U4C9 uc007hea.1 uc007hea.2 uc007hea.3 Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro) (By similarity). Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Activated by autophosphorylation on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop. Component of an E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 (EDVP complex). Interacts directly with EDD/UBR5, DDB1 and DCAF1. Interacts with SIAH2 and MDM2. Interacts with MAP3K10 and NFATC1. May also interact with CCNL2 (By similarity). Cytoplasm Nucleus Note=Translocates into the nucleus following DNA damage. Autophosphorylates cotranslationally on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop, but once mature, does not have any protein tyrosine kinase activity. Phosphorylated at Thr-104 and Ser-440 by ATM in response to genotoxic stress. Under normal conditions, polyubiquitinated in the nucleus by MDM2, leading to its proteasomal degradation. Phosphorylation on Thr-104 and Ser-440 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasomal degradation. Polyubiquitinated by SIAH2, leading to its proteasomal degradation. Polyubiquitinated by SIAH2 occurs under normal conditions, and is enhanced in response to hypoxia. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. ubiquitin ligase complex nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity ATP binding nucleus nucleoplasm cytoplasm cytosol cytoskeleton protein phosphorylation apoptotic process cellular response to DNA damage stimulus smoothened signaling pathway kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation manganese ion binding intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of glycogen biosynthetic process negative regulation of calcineurin-NFAT signaling cascade ribonucleoprotein complex uc007hea.1 uc007hea.2 uc007hea.3 
ENSMUST00000004294.12 Kifc2 ENSMUST00000004294.12 kinesin family member C2, transcript variant 22 (from RefSeq NR_183666.1) ENSMUST00000004294.1 ENSMUST00000004294.10 ENSMUST00000004294.11 ENSMUST00000004294.2 ENSMUST00000004294.3 ENSMUST00000004294.4 ENSMUST00000004294.5 ENSMUST00000004294.6 ENSMUST00000004294.7 ENSMUST00000004294.8 ENSMUST00000004294.9 G3X8Q6 G3X8Q6_MOUSE Kifc2 NR_183666 uc007wll.1 uc007wll.2 uc007wll.3 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding motor activity microtubule motor activity ATP binding microtubule microtubule-based movement microtubule binding uc007wll.1 uc007wll.2 uc007wll.3 
ENSMUST00000004326.4 Plxna3 ENSMUST00000004326.4 plexin A3, transcript variant 1 (from RefSeq NM_008883.2) A5D6Q5 ENSMUST00000004326.1 ENSMUST00000004326.2 ENSMUST00000004326.3 NM_008883 P70208 PLXA3_MOUSE Q684J0 Q8BWZ5 uc009too.1 uc009too.2 Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Cell membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70208-1; Sequence=Displayed; Name=2; IsoId=P70208-2; Sequence=VSP_041609; Detected in embryonic hindbrain, spinal cord, dorsal root ganglion, trigeminal ganglion and superior cervical ganglion. In newborns, detected throughout all layers of the hippocampus. No visible phenotype, but causes subtle changes in the central nervous system. Mice exhibit altered apical dendrite spine morphology in pyramidal neurons. Mice exhibit defasciculation of the facial branchiomotor nerve and of the ophthalmic branch of the trigeminus, with variable severity. The number of neurons in the dorsal root ganglion is higher than normal, probably due to reduced neuronal apoptosis. In mice lacking both Plxna3 and Plxna4, migrating neurons do not show the normal response to Sema3A and Sema3F and do not migrate away from these semaphorins (in vitro). Belongs to the plexin family. semaphorin receptor complex nucleus plasma membrane integral component of plasma membrane negative regulation of cell adhesion signal transduction axon guidance regulation of cell shape membrane integral component of membrane semaphorin receptor activity facial nerve structural organization trigeminal nerve structural organization hippocampus development branchiomotor neuron axon guidance pyramidal neuron development cell junction regulation of cell migration regulation of GTPase activity intracellular membrane-bounded organelle negative regulation of axon extension involved in axon guidance positive regulation of axonogenesis negative chemotaxis positive regulation of cytoskeleton organization semaphorin-plexin signaling pathway neuron projection guidance semaphorin-plexin signaling pathway involved in axon guidance neuron projection extension uc009too.1 uc009too.2 
ENSMUST00000004327.11 G6pdx ENSMUST00000004327.11 glucose-6-phosphate dehydrogenase X-linked (from RefSeq NM_008062.3) ENSMUST00000004327.1 ENSMUST00000004327.10 ENSMUST00000004327.2 ENSMUST00000004327.3 ENSMUST00000004327.4 ENSMUST00000004327.5 ENSMUST00000004327.6 ENSMUST00000004327.7 ENSMUST00000004327.8 ENSMUST00000004327.9 G6pdx NM_008062 Q790Y8 Q790Y8_MOUSE RP23-436K3.17-001 uc009toy.1 uc009toy.2 uc009toy.3 Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5- lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57955, ChEBI:CHEBI:58349, ChEBI:CHEBI:61548; EC=1.1.1.49; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15842; Evidence=; Carbohydrate degradation; pentose phosphate pathway; D- ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Belongs to the glucose-6-phosphate dehydrogenase family. glucose-6-phosphate dehydrogenase activity carbohydrate metabolic process glucose metabolic process pentose-phosphate shunt oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors NADP binding oxidation-reduction process uc009toy.1 uc009toy.2 uc009toy.3 
ENSMUST00000004343.7 Wars2 ENSMUST00000004343.7 tryptophanyl tRNA synthetase 2 (mitochondrial) (from RefSeq NR_185000.1) ENSMUST00000004343.1 ENSMUST00000004343.2 ENSMUST00000004343.3 ENSMUST00000004343.4 ENSMUST00000004343.5 ENSMUST00000004343.6 NR_185000 Q8BFV8 Q9CYK1 SYWM_MOUSE uc008qqk.1 uc008qqk.2 uc008qqk.3 Catalyzes the attachment of tryptophan to tRNA(Trp) in a two- step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of tRNA(Trp). Reaction=ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L- tryptophanyl-tRNA(Trp); Xref=Rhea:RHEA:24080, Rhea:RHEA-COMP:9671, Rhea:RHEA-COMP:9705, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57912, ChEBI:CHEBI:78442, ChEBI:CHEBI:78535, ChEBI:CHEBI:456215; EC=6.1.1.2; Evidence=; Mitochondrion matrix Mitochondrion Belongs to the class-I aminoacyl-tRNA synthetase family. nucleotide binding vasculogenesis aminoacyl-tRNA ligase activity tryptophan-tRNA ligase activity ATP binding mitochondrion mitochondrial matrix cytosol plasma membrane translation tRNA aminoacylation for protein translation tryptophanyl-tRNA aminoacylation ligase activity mitochondrial tryptophanyl-tRNA aminoacylation uc008qqk.1 uc008qqk.2 uc008qqk.3 
ENSMUST00000004375.16 Phb2 ENSMUST00000004375.16 prohibitin 2 (from RefSeq NM_007531.2) ENSMUST00000004375.1 ENSMUST00000004375.10 ENSMUST00000004375.11 ENSMUST00000004375.12 ENSMUST00000004375.13 ENSMUST00000004375.14 ENSMUST00000004375.15 ENSMUST00000004375.2 ENSMUST00000004375.3 ENSMUST00000004375.4 ENSMUST00000004375.5 ENSMUST00000004375.6 ENSMUST00000004375.7 ENSMUST00000004375.8 ENSMUST00000004375.9 NM_007531 Phb2 Q3V235 Q3V235_MOUSE uc033iur.1 uc033iur.2 uc033iur.3 Protein with pleiotropic attributes mediated in a cell- compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. Cell membrane Membrane Mitochondrion inner membrane Belongs to the prohibitin family. nucleus cytoplasm mitochondrion mitochondrial outer membrane mitochondrial inner membrane protein import into nucleus mitochondrion organization sister chromatid cohesion protein C-terminus binding response to wounding cell surface postsynaptic density membrane nuclear matrix axon positive regulation of exit from mitosis macromolecular complex amide binding negative regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated sphingolipid binding protein N-terminus binding presynaptic active zone protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to hypoxia cell periphery glutamatergic synapse GABA-ergic synapse positive regulation of cell cycle G1/S phase transition regulation of cytochrome-c oxidase activity uc033iur.1 uc033iur.2 uc033iur.3 
ENSMUST00000004378.15 Eno2 ENSMUST00000004378.15 enolase 2, gamma neuronal, transcript variant 14 (from RefSeq NR_176890.1) ENSMUST00000004378.1 ENSMUST00000004378.10 ENSMUST00000004378.11 ENSMUST00000004378.12 ENSMUST00000004378.13 ENSMUST00000004378.14 ENSMUST00000004378.2 ENSMUST00000004378.3 ENSMUST00000004378.4 ENSMUST00000004378.5 ENSMUST00000004378.6 ENSMUST00000004378.7 ENSMUST00000004378.8 ENSMUST00000004378.9 Eno2 NR_176890 Q545V3 Q545V3_MOUSE uc009drs.1 uc009drs.2 uc009drs.3 uc009drs.4 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 4/5. Belongs to the enolase family. phosphopyruvate hydratase complex magnesium ion binding phosphopyruvate hydratase activity cytosol plasma membrane glycolytic process membrane uc009drs.1 uc009drs.2 uc009drs.3 uc009drs.4 
ENSMUST00000004379.8 Emg1 ENSMUST00000004379.8 EMG1 N1-specific pseudouridine methyltransferase, transcript variant 1 (from RefSeq NM_013536.3) ENSMUST00000004379.1 ENSMUST00000004379.2 ENSMUST00000004379.3 ENSMUST00000004379.4 ENSMUST00000004379.5 ENSMUST00000004379.6 ENSMUST00000004379.7 Emg1 Grcc2f NM_013536 Q542P8 Q542P8_MOUSE uc009drg.1 uc009drg.2 uc009drg.3 uc009drg.4 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. nucleus nucleolus methyltransferase activity rRNA methylation methylation rRNA (pseudouridine) methyltransferase activity uc009drg.1 uc009drg.2 uc009drg.3 uc009drg.4 
ENSMUST00000004381.14 Lpcat3 ENSMUST00000004381.14 lysophosphatidylcholine acyltransferase 3, transcript variant 4 (from RefSeq NR_176914.1) B1B362 ENSMUST00000004381.1 ENSMUST00000004381.10 ENSMUST00000004381.11 ENSMUST00000004381.12 ENSMUST00000004381.13 ENSMUST00000004381.2 ENSMUST00000004381.3 ENSMUST00000004381.4 ENSMUST00000004381.5 ENSMUST00000004381.6 ENSMUST00000004381.7 ENSMUST00000004381.8 ENSMUST00000004381.9 Grcc3f MBOA5_MOUSE Mboat5 NR_176914 O35131 Oact5 Q8BNH6 Q91V01 uc009drf.1 uc009drf.2 uc009drf.3 uc009drf.4 Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle (PubMed:18287005, PubMed:25898003). Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (PubMed:18287005, PubMed:25898003). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs (PubMed:18287005). Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (PubMed:18287005). Acts as a major LPC O-acyltransferase in liver and intestine (PubMed:25898003, PubMed:26833026). As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (PubMed:25806685). Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (PubMed:28846071). Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation (PubMed:24206663). Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (PubMed:24206663). In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (PubMed:26833026). In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (PubMed:29395055). Reaction=a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2- diacyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:12937, ChEBI:CHEBI:57287, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:58342; EC=2.3.1.23; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12938; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:32995, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64381, ChEBI:CHEBI:64612; EC=2.3.1.n7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32996; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2- diacyl-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:33191, ChEBI:CHEBI:57262, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64379; EC=2.3.1.n6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33192; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3- phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:37563, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:58168, ChEBI:CHEBI:60000; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37564; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3- phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn- glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37559, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:58168, ChEBI:CHEBI:75063; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37560; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37515, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:72998, ChEBI:CHEBI:75018; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37516; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35987, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:72998, ChEBI:CHEBI:73000; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35988; Evidence=; Reaction=1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37511, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74966, ChEBI:CHEBI:75017; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37512; Evidence=; Reaction=1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37655, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:64489, ChEBI:CHEBI:75062; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37656; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35983, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35984; Evidence=; Reaction=1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37527, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:73858, ChEBI:CHEBI:75026; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37528; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:37383, ChEBI:CHEBI:28610, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74667; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37384; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:37207, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:72998, ChEBI:CHEBI:74000; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37208; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:35991, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35992; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn- glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35995, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35996; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn- glycero-3-phosphocholine = 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37483, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74966, ChEBI:CHEBI:74967; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37484; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn- glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35999, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36000; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn- glycero-3-phosphocholine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37479, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:73858, ChEBI:CHEBI:74965; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37480; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn- glycero-3-phosphocholine = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37487, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74968, ChEBI:CHEBI:74970; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37488; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37387, ChEBI:CHEBI:28610, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74669; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37388; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero- 3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn- glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37391, ChEBI:CHEBI:28610, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74670; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37392; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn- glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)- icosatetraenoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37395, ChEBI:CHEBI:28610, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74671; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37396; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3- phosphoethanolamine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3- phosphoethanolamine + CoA; Xref=Rhea:RHEA:37579, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:64381, ChEBI:CHEBI:75069; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37580; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero- 3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)- octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37503, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74971, ChEBI:CHEBI:74977; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37504; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn- glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:64228, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:149768, ChEBI:CHEBI:149770; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64229; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3- phosphoethanolamine = 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37575, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:64381, ChEBI:CHEBI:75067; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37576; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn- glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:36023, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36024; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn- glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37495, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74971, ChEBI:CHEBI:74975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37496; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)- sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:64204, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:149768, ChEBI:CHEBI:149769; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64205; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn- glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37635, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:77288, ChEBI:CHEBI:77295; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37636; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho- L-serine = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L- serine + CoA; Xref=Rhea:RHEA:37567, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:64379, ChEBI:CHEBI:75066; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37568; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3- phospho-L-serine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn- glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37571, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:64379, ChEBI:CHEBI:75065; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37572; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L- serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L- serine + CoA; Xref=Rhea:RHEA:37531, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75020, ChEBI:CHEBI:75029; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37532; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phospho-L-serine = 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L- serine + CoA; Xref=Rhea:RHEA:37407, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74617, ChEBI:CHEBI:74905; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37408; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phospho-L-serine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn- glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37535, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:75020, ChEBI:CHEBI:75031; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37536; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero- 3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn- glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37375, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74617, ChEBI:CHEBI:74892; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37376; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn- glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37539, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:75020, ChEBI:CHEBI:75032; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37540; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn- glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37379, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74617, ChEBI:CHEBI:74897; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37380; Evidence=; Kinetic parameters: KM=7.8 uM for arachidonoyl-CoA (in the presence of LPC C16:0 as cosubstrate) ; KM=44.1 uM for arachidonoyl-CoA (in the presence of LPE C18:1 as cosubstrate) ; KM=28 uM for arachidonoyl-CoA (in the presence of LPS C18:1 as cosubstrate) ; KM=34.5 uM for LPC C16:0 (in the presence of arachidonoyl-CoA as cosubstrate) ; KM=29.7 uM for LPE C18:1 (in the presence of arachidonoyl-CoA as cosubstrate) ; KM=22.3 uM for LPS C18:1 (in the presence of arachidonoyl-CoA as cosubstrate) ; Vmax=1085.5 nmol/min/mg enzyme with arachidonoyl-CoA and LPC C16:0 as substrates ; Vmax=389.25 nmol/min/mg enzyme with arachidonoyl-CoA and LPE C18:1 as substrates ; Vmax=335.75 nmol/min/mg enzyme with arachidonoyl-CoA and LPS C18:1 as substrates ; Lipid metabolism; phospholipid metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Detected ubiquitously, with high expression levels in small intestine, brown adipose tissue, liver, kidney and testis (PubMed:18287005, PubMed:28846071, PubMed:25898003, PubMed:25806685, PubMed:24206663). Expressed in liver and both proximal and distal small intestine (at protein level) (PubMed:25898003). Expressed in peritoneal macrophages (PubMed:24206663). Expressed at late embryonic stages between 18.5 and 19.5 dpc in intestine and liver. Up-regulated in response to liver X receptor/NR1H3 or NR1H2 agonist GW3965 (PubMed:28846071, PubMed:25898003, PubMed:25806685, PubMed:24206663). Up-regulated in peritoneal macrophages upon exposure to 22(R)-hydroxycholesterol (PubMed:24206663). The di-lysine motif confers endoplasmic reticulum localization. Mutant mice are born at the expected Mendelian frequency, but none survives beyond day 2 due to an extensive triacylglycerol accumulation in enterocytes associated with very low blood glucose levels at birth (P1.5) (PubMed:25806685, PubMed:25898003). Conditional knockdown in intestine results in hyperproliferation of the intestinal crypt and increased susceptibility to intestinal tumorigenesis (PubMed:29395055). Belongs to the membrane-bound acyltransferase family. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phospholipid metabolic process phospholipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups 1-acylglycerophosphocholine O-acyltransferase activity regulation of plasma lipoprotein particle levels uc009drf.1 uc009drf.2 uc009drf.3 uc009drf.4 
ENSMUST00000004389.6 Grcc10 ENSMUST00000004389.6 gene rich cluster, C10 gene (from RefSeq NM_013535.2) C10 C10_MOUSE ENSMUST00000004389.1 ENSMUST00000004389.2 ENSMUST00000004389.3 ENSMUST00000004389.4 ENSMUST00000004389.5 NM_013535 O35127 Q545G8 uc009drn.1 uc009drn.2 uc009drn.3 uc009drn.4 In brain, may be required for corpus callosum development. Cytoplasm Ubiquitously expressed, with higher expression in lung. Detected as early as 10.5 dpc. Belongs to the UPF0456 family. molecular_function cytoplasm post-embryonic development regulation of skeletal muscle contraction nuclear speck corpus callosum morphogenesis third ventricle development psychomotor behavior camera-type eye morphogenesis cognition uc009drn.1 uc009drn.2 uc009drn.3 uc009drn.4 
ENSMUST00000004392.12 Irf5 ENSMUST00000004392.12 interferon regulatory factor 5, transcript variant 2 (from RefSeq NM_012057.4) ENSMUST00000004392.1 ENSMUST00000004392.10 ENSMUST00000004392.11 ENSMUST00000004392.2 ENSMUST00000004392.3 ENSMUST00000004392.4 ENSMUST00000004392.5 ENSMUST00000004392.6 ENSMUST00000004392.7 ENSMUST00000004392.8 ENSMUST00000004392.9 Irf5 NM_012057 Q3U169 Q3U169_MOUSE uc009bdu.1 uc009bdu.2 uc009bdu.3 uc009bdu.4 transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cytokine-mediated signaling pathway response to peptidoglycan response to muramyl dipeptide identical protein binding positive regulation of apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter defense response to virus uc009bdu.1 uc009bdu.2 uc009bdu.3 uc009bdu.4 
ENSMUST00000004396.13 Atp6v1f ENSMUST00000004396.13 ATPase, H+ transporting, lysosomal V1 subunit F (from RefSeq NM_025381.2) Atp6s14 ENSMUST00000004396.1 ENSMUST00000004396.10 ENSMUST00000004396.11 ENSMUST00000004396.12 ENSMUST00000004396.2 ENSMUST00000004396.3 ENSMUST00000004396.4 ENSMUST00000004396.5 ENSMUST00000004396.6 ENSMUST00000004396.7 ENSMUST00000004396.8 ENSMUST00000004396.9 NM_025381 Q3U6X0 Q9D1K2 VATF_MOUSE Vatf uc009bdp.1 uc009bdp.2 uc009bdp.3 Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein Belongs to the V-ATPase F subunit family. ion transport membrane vacuolar proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain ion transmembrane transport ATPase coupled ion transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism hydrogen ion transmembrane transport uc009bdp.1 uc009bdp.2 uc009bdp.3 
ENSMUST00000004428.14 Clcn5 ENSMUST00000004428.14 chloride channel, voltage-sensitive 5, transcript variant 1 (from RefSeq NM_016691.4) B1ATV0 B1AXN0 CLCN5_MOUSE Clc5 ENSMUST00000004428.1 ENSMUST00000004428.10 ENSMUST00000004428.11 ENSMUST00000004428.12 ENSMUST00000004428.13 ENSMUST00000004428.2 ENSMUST00000004428.3 ENSMUST00000004428.4 ENSMUST00000004428.5 ENSMUST00000004428.6 ENSMUST00000004428.7 ENSMUST00000004428.8 ENSMUST00000004428.9 NM_016691 Q9WVD4 uc009sle.1 uc009sle.2 uc009sle.3 uc009sle.4 uc009sle.5 Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). Reaction=2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in); Xref=Rhea:RHEA:29567, ChEBI:CHEBI:15378, ChEBI:CHEBI:17996; Evidence=; Interacts with NEDD4 and NEDD4L. Golgi apparatus membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WVD4-1; Sequence=Displayed; Name=2; IsoId=Q9WVD4-2; Sequence=VSP_060655; Kidney specific. Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation. Belongs to the chloride channel (TC 2.A.49) family. ClC- 5/CLCN5 subfamily. Golgi membrane nucleotide binding voltage-gated chloride channel activity chloride channel activity ATP binding endosome early endosome Golgi apparatus cytosol plasma membrane integral component of plasma membrane ion transport chloride transport endocytosis synaptic vesicle endosome membrane antiporter activity solute:proton antiporter activity membrane integral component of membrane chloride ion binding identical protein binding apical part of cell transmembrane transport chloride transmembrane transport hydrogen ion transmembrane transport uc009sle.1 uc009sle.2 uc009sle.3 uc009sle.4 uc009sle.5 
ENSMUST00000004453.9 Gpx6 ENSMUST00000004453.9 glutathione peroxidase 6 (from RefSeq NM_145451.3) ENSMUST00000004453.1 ENSMUST00000004453.2 ENSMUST00000004453.3 ENSMUST00000004453.4 ENSMUST00000004453.5 ENSMUST00000004453.6 ENSMUST00000004453.7 ENSMUST00000004453.8 F2Z3U8 GPX6_MOUSE NM_145451 Q91WR8 uc007pqa.1 uc007pqa.2 uc007pqa.3 This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidases catalyze the reduction of a variety of hydroperoxides using glutathione as a specific electron donor substrate, and thereby protect cells against oxidative damage. Expression of this gene is restricted to embryos and adult olfactory epithelium. The mouse and rat orthologs contain a cysteine (Cys) residue at the active site, unlike the human counterpart, which is a selenoprotein, containing selenocysteine (Sec) instead. [provided by RefSeq, Jul 2017]. ##Evidence-Data-START## Transcript exon combination :: AW012267.1, CB955103.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; Secreted Belongs to the glutathione peroxidase family. peroxidase activity glutathione peroxidase activity extracellular region response to oxidative stress oxidoreductase activity oxidation-reduction process cellular oxidant detoxification uc007pqa.1 uc007pqa.2 uc007pqa.3 
ENSMUST00000004470.9 Utp20 ENSMUST00000004470.9 UTP20 small subunit processome component (from RefSeq NM_175158.3) E9QK83 E9QK83_MOUSE ENSMUST00000004470.1 ENSMUST00000004470.2 ENSMUST00000004470.3 ENSMUST00000004470.4 ENSMUST00000004470.5 ENSMUST00000004470.6 ENSMUST00000004470.7 ENSMUST00000004470.8 NM_175158 Utp20 uc007grx.1 uc007grx.2 uc007grx.3 uc007grx.4 nucleolus plasma membrane rRNA processing uc007grx.1 uc007grx.2 uc007grx.3 uc007grx.4 
ENSMUST00000004473.15 Spic ENSMUST00000004473.15 Spi-C transcription factor (Spi-1/PU.1 related) (from RefSeq NM_011461.3) ENSMUST00000004473.1 ENSMUST00000004473.10 ENSMUST00000004473.11 ENSMUST00000004473.12 ENSMUST00000004473.13 ENSMUST00000004473.14 ENSMUST00000004473.2 ENSMUST00000004473.3 ENSMUST00000004473.4 ENSMUST00000004473.5 ENSMUST00000004473.6 ENSMUST00000004473.7 ENSMUST00000004473.8 ENSMUST00000004473.9 NM_011461 Q3U064 Q3U0G6 Q3U1E9 Q6P3D7 Q9Z0Y0 SPIC_MOUSE uc007grv.1 uc007grv.2 uc007grv.3 uc007grv.4 uc007grv.5 Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression. Binds DNA as a monomer. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P3D7-1; Sequence=Displayed; Name=2; IsoId=Q6P3D7-2; Sequence=VSP_037734, VSP_037735; Expressed in lymphoid tissues, including spleen, bone marrow and thymus. According to PubMed:19037245, highly expressed in red pulp macrophages and, at lower, levels in B-cells, but not in other cells, including, monocytes, dendritic cells and other tissue macrophages. According to PubMed:10464163 expressed in pre- and mature B-cells but not in immature B-cells; according to PubMed:10187812 not expressed in pre- but predominantly in mature B-cells and at lower levels in macrophages. Cell-autonomous defect in the development of red pulp macrophages, but normal monocyte and other macrophage subsets. Mice show normal trapping of red blood cells in the spleen, but fail to phagocytose these cells efficiently and develop an iron overload localized selectively to splenic red pulp. Belongs to the ETS family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding blastocyst development DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc007grv.1 uc007grv.2 uc007grv.3 uc007grv.4 uc007grv.5 
ENSMUST00000004480.5 Sst ENSMUST00000004480.5 somatostatin, transcript variant 1 (from RefSeq NM_009215.2) ENSMUST00000004480.1 ENSMUST00000004480.2 ENSMUST00000004480.3 ENSMUST00000004480.4 NM_009215 Q545V6 Q545V6_MOUSE Sst uc007ytx.1 uc007ytx.2 uc007ytx.3 Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. Secreted Belongs to the somatostatin family. hormone activity extracellular region extracellular space hyperosmotic response signal transduction response to heat response to organonitrogen compound response to acidic pH response to drug neuronal cell body response to amino acid response to steroid hormone uc007ytx.1 uc007ytx.2 uc007ytx.3 
ENSMUST00000004494.16 Sin3b ENSMUST00000004494.16 transcriptional regulator, SIN3B (yeast), transcript variant 1 (from RefSeq NM_009188.4) ENSMUST00000004494.1 ENSMUST00000004494.10 ENSMUST00000004494.11 ENSMUST00000004494.12 ENSMUST00000004494.13 ENSMUST00000004494.14 ENSMUST00000004494.15 ENSMUST00000004494.2 ENSMUST00000004494.3 ENSMUST00000004494.4 ENSMUST00000004494.5 ENSMUST00000004494.6 ENSMUST00000004494.7 ENSMUST00000004494.8 ENSMUST00000004494.9 Kiaa0700 NM_009188 O54976 Q62141 Q6A013 Q8VCB8 Q8VDZ5 SIN3B_MOUSE uc009mgq.1 uc009mgq.2 uc009mgq.3 uc009mgq.4 uc009mgq.5 uc009mgq.6 Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904). Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1. Interacts with MYT1L (PubMed:28379941). Interacts with C6orf89 (By similarity). Q62141; Q6PDX6: Rnf220; NbExp=5; IntAct=EBI-591450, EBI-2795840; Q62141; Q8BR65: Suds3; NbExp=5; IntAct=EBI-591450, EBI-591431; Q62141; P01106: MYC; Xeno; NbExp=8; IntAct=EBI-591450, EBI-447544; Q62141-2; P42128: Foxk1; NbExp=11; IntAct=EBI-591466, EBI-878270; Nucleus Event=Alternative splicing; Named isoforms=4; Name=4; IsoId=Q62141-4; Sequence=Displayed; Name=1; IsoId=Q62141-1; Sequence=VSP_014187; Name=2; IsoId=Q62141-2; Sequence=VSP_008225, VSP_008226, VSP_014187; Name=3; IsoId=Q62141-3; Sequence=VSP_008227, VSP_008228, VSP_014187; Ubiquitinated by RNF220 that leads to proteasomal degradation. Sequence=BAD32283.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter chromatin X chromosome Y chromosome XY body chromatin binding transcription corepressor activity protein binding nucleus cytoplasm regulation of transcription, DNA-templated skeletal muscle tissue development histone deacetylation Sin3 complex autosome negative regulation of cell cycle negative regulation of transcription, DNA-templated cardiac muscle tissue development histone deacetylase activity uc009mgq.1 uc009mgq.2 uc009mgq.3 uc009mgq.4 uc009mgq.5 uc009mgq.6 
ENSMUST00000004505.3 Npc1l1 ENSMUST00000004505.3 NPC1 like intracellular cholesterol transporter 1 (from RefSeq NM_207242.2) ENSMUST00000004505.1 ENSMUST00000004505.2 NM_207242 Npc1l1 Z4YJC9 Z4YJC9_MOUSE uc007hyb.1 uc007hyb.2 uc007hyb.3 uc007hyb.4 Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747, ChEBI:CHEBI:16113; Evidence=; Belongs to the patched family. lipid transporter activity cholesterol biosynthetic process drug binding membrane integral component of membrane Rab GTPase binding intestinal cholesterol absorption cholesterol transport myosin V binding brush border membrane lipoprotein metabolic process response to drug spanning component of plasma membrane cellular response to sterol depletion uc007hyb.1 uc007hyb.2 uc007hyb.3 uc007hyb.4 
ENSMUST00000004507.11 Ddx56 ENSMUST00000004507.11 DEAD box helicase 56, transcript variant 6 (from RefSeq NR_184558.1) D11Ertd619e DDX56_MOUSE ENSMUST00000004507.1 ENSMUST00000004507.10 ENSMUST00000004507.2 ENSMUST00000004507.3 ENSMUST00000004507.4 ENSMUST00000004507.5 ENSMUST00000004507.6 ENSMUST00000004507.7 ENSMUST00000004507.8 ENSMUST00000004507.9 NR_184558 Noh61 Q9D0R4 uc007hyc.1 uc007hyc.2 uc007hyc.3 Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization. Plays an essential role in maintaining nucleolar integrity in planarian stem cells (PubMed:32703285). Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex (PubMed:32703285). Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3. Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5. May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; May form homooligomeric complexes. Interacts with IRF3 (By similarity). Interacts with OCT4 and POU5F1 (PubMed:32703285). Nucleus, nucleolus Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus nucleolus rRNA processing positive regulation of neuron projection development hydrolase activity ribosome biogenesis uc007hyc.1 uc007hyc.2 uc007hyc.3 
ENSMUST00000004508.13 Tmed4 ENSMUST00000004508.13 transmembrane p24 trafficking protein 4 (from RefSeq NM_134020.1) ENSMUST00000004508.1 ENSMUST00000004508.10 ENSMUST00000004508.11 ENSMUST00000004508.12 ENSMUST00000004508.2 ENSMUST00000004508.3 ENSMUST00000004508.4 ENSMUST00000004508.5 ENSMUST00000004508.6 ENSMUST00000004508.7 ENSMUST00000004508.8 ENSMUST00000004508.9 Ers25 NM_134020 Q3TY55 Q8R1V4 TMED4_MOUSE uc007hye.1 uc007hye.2 uc007hye.3 Involved in vesicular protein trafficking, mainly in the early secretory pathway. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity). Endoplasmic reticulum membrane ; Single-pass type I membrane protein By brefeldin A, oxidative stress and heat shock, but not by tunicamycin, hypersomotic stress or serum starvation. Belongs to the EMP24/GP25L family. endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus intracellular protein transport ER to Golgi vesicle-mediated transport Golgi organization protein transport membrane integral component of membrane ER to Golgi transport vesicle uc007hye.1 uc007hye.2 uc007hye.3 
ENSMUST00000004554.14 Rps5 ENSMUST00000004554.14 ribosomal protein S5, transcript variant 2 (from RefSeq NM_009095.3) ENSMUST00000004554.1 ENSMUST00000004554.10 ENSMUST00000004554.11 ENSMUST00000004554.12 ENSMUST00000004554.13 ENSMUST00000004554.2 ENSMUST00000004554.3 ENSMUST00000004554.4 ENSMUST00000004554.5 ENSMUST00000004554.6 ENSMUST00000004554.7 ENSMUST00000004554.8 ENSMUST00000004554.9 NM_009095 O08607 P97461 Q91V55 RS5_MOUSE uc009fep.1 uc009fep.2 uc009fep.3 uc009fep.4 Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Component of the small ribosomal subunit (PubMed:36517592). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Cytoplasm Nucleus, nucleolus Belongs to the universal ribosomal protein uS7 family. ribosomal small subunit assembly RNA binding mRNA binding structural constituent of ribosome ribosome translation regulation of translational fidelity small ribosomal subunit rRNA binding cytosolic small ribosomal subunit ribonucleoprotein complex uc009fep.1 uc009fep.2 uc009fep.3 uc009fep.4 
ENSMUST00000004560.12 Bid ENSMUST00000004560.12 BH3 interacting domain death agonist (from RefSeq NM_007544.4) BID_MOUSE ENSMUST00000004560.1 ENSMUST00000004560.10 ENSMUST00000004560.11 ENSMUST00000004560.2 ENSMUST00000004560.3 ENSMUST00000004560.4 ENSMUST00000004560.5 ENSMUST00000004560.6 ENSMUST00000004560.7 ENSMUST00000004560.8 ENSMUST00000004560.9 NM_007544 P70444 Q99M39 uc009dnv.1 uc009dnv.2 uc009dnv.3 Induces caspases and apoptosis. Counters the protective effect of BCL2. [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (By similarity). Allows the release of cytochrome c (PubMed:9873064). Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2 (PubMed:21183079). Interacts with PLEKHN1 (By similarity). [BH3-interacting domain death agonist p15]: Interacts with ITCH (PubMed:20392206). Interacts with MTCH2 (PubMed:15899861). P70444; Q07440: Bcl2a1; NbExp=2; IntAct=EBI-783400, EBI-707754; P70444; Q07812: BAX; Xeno; NbExp=2; IntAct=EBI-783400, EBI-516580; PRO_0000223236; Q07812: BAX; Xeno; NbExp=2; IntAct=EBI-2128640, EBI-516580; Cytoplasm Mitochondrion membrane Mitochondrion outer membrane Note=When uncleaved, it is predominantly cytoplasmic. [BH3-interacting domain death agonist p15]: Mitochondrion membrane Note=Translocates to mitochondria as an integral membrane protein. [BH3-interacting domain death agonist p13]: Mitochondrion membrane Note=Associated with the mitochondrial membrane. Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti- apoptotic members of the Bcl-2 family. Apoptotic members of the Bcl-2 family. [BH3-interacting domain death agonist]: TNF-alpha induces caspase- mediated cleavage into a major p15 and minor p13 and p11 products (PubMed:9873064). Cleaved by CASP6 into a major p15 and minor p13 products, leading to release of cytochrome c and subsequent nonalcoholic steatohepatitis (By similarity). [BH3-interacting domain death agonist p15]: Ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation. release of cytochrome c from mitochondria response to ischemia protein binding cytoplasm mitochondrion mitochondrial outer membrane cytosol protein targeting to mitochondrion apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process brain development apoptotic mitochondrial changes positive regulation of mitochondrial membrane potential membrane positive regulation of protein complex assembly ubiquitin protein ligase binding mitochondrial membrane response to estradiol regulation of protein oligomerization positive regulation of protein oligomerization positive regulation of protein homooligomerization integral component of mitochondrial membrane autophagy in response to ER overload glial cell apoptotic process regulation of cell proliferation signal transduction in response to DNA damage mitochondrial ATP synthesis coupled electron transport regulation of apoptotic process positive regulation of apoptotic process protein heterodimerization activity macromolecular complex assembly establishment of protein localization to membrane positive regulation of release of cytochrome c from mitochondria extrinsic apoptotic signaling pathway hepatocyte apoptotic process mitochondrial outer membrane permeabilization regulation of mitochondrial membrane permeability involved in apoptotic process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of G1/S transition of mitotic cell cycle positive regulation of fibroblast apoptotic process positive regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway uc009dnv.1 uc009dnv.2 uc009dnv.3 
ENSMUST00000004565.15 Ralb ENSMUST00000004565.15 v-ral simian leukemia viral oncogene B (from RefSeq NM_022327.5) ENSMUST00000004565.1 ENSMUST00000004565.10 ENSMUST00000004565.11 ENSMUST00000004565.12 ENSMUST00000004565.13 ENSMUST00000004565.14 ENSMUST00000004565.2 ENSMUST00000004565.3 ENSMUST00000004565.4 ENSMUST00000004565.5 ENSMUST00000004565.6 ENSMUST00000004565.7 ENSMUST00000004565.8 ENSMUST00000004565.9 NM_022327 Q3TVS5 Q9JIW9 RALB_MOUSE uc007cis.1 uc007cis.2 uc007cis.3 uc007cis.4 Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (By similarity). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide- exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Interacts with EXOC2/Sec5 and EXOC8/Exo84 (By similarity). Interacts (via effector domain) with RALBP1 (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Midbody Note=During late cytokinesis, enriched at the midbody. Prenylation is essential for membrane localization. The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of some geranylgeranyltransferase I inhibitors. Belongs to the small GTPase superfamily. Ras family. nucleotide binding regulation of exocyst assembly positive regulation of protein phosphorylation GTPase activity GTP binding plasma membrane apoptotic process cell cycle signal transduction Ras protein signal transduction cellular response to starvation membrane GDP binding midbody ubiquitin protein ligase binding negative regulation of protein binding positive regulation of protein binding ATPase binding cell division regulation of exocyst localization cellular response to exogenous dsRNA positive regulation of protein serine/threonine kinase activity positive regulation of autophagosome assembly uc007cis.1 uc007cis.2 uc007cis.3 uc007cis.4 
ENSMUST00000004576.8 Tbccd1 ENSMUST00000004576.8 TBCC domain containing 1, transcript variant 1 (from RefSeq NM_001081368.2) ENSMUST00000004576.1 ENSMUST00000004576.2 ENSMUST00000004576.3 ENSMUST00000004576.4 ENSMUST00000004576.5 ENSMUST00000004576.6 ENSMUST00000004576.7 NM_001081368 Q640P7 Q68FM1 Q8CA17 Q9CYG4 TBCC1_MOUSE uc007ysl.1 uc007ysl.2 uc007ysl.3 Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Note=Localizes at the spindle midzone, midbody and basal bodies of primary and motile cilia. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q640P7-1; Sequence=Displayed; Name=2; IsoId=Q640P7-2; Sequence=VSP_028139, VSP_028140; Expressed in brain and testis (at protein level). Belongs to the TBCC family. Sequence=BAC30476.1; Type=Frameshift; Evidence=; cell morphogenesis spindle pole molecular_function cytoplasm microtubule organizing center cytoskeleton regulation of cell shape regulation of cell migration spindle pole centrosome maintenance of centrosome location maintenance of Golgi location uc007ysl.1 uc007ysl.2 uc007ysl.3 
ENSMUST00000004587.11 Clec11a ENSMUST00000004587.11 C-type lectin domain family 11, member a (from RefSeq NM_009131.3) CLC11_MOUSE ENSMUST00000004587.1 ENSMUST00000004587.10 ENSMUST00000004587.2 ENSMUST00000004587.3 ENSMUST00000004587.4 ENSMUST00000004587.5 ENSMUST00000004587.6 ENSMUST00000004587.7 ENSMUST00000004587.8 ENSMUST00000004587.9 NM_009131 O88200 Q8C946 Q9CTF0 Scgf uc009gpb.1 uc009gpb.2 uc009gpb.3 uc009gpb.4 Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult bone. Cytoplasm Secreted Detected in femur where it localizes to trabecular bone of the femur metaphysis, and cortical bone of the proximal femur. Also expressed in trabecular and cortical bone of vertebrae (at protein level). Strongly expressed in osteoblasts and bone marrow stromal cells. Also has very weak expression in B cell progenitors in the bone marrow and T cells in the spleen. O-glycosylated. Probably sulfated on the O-glycans (By similarity). Viable with no gross defects. Trabecular bone volume and bone mineral density is significantly reduced at two months of age, and progressively worsens with age. Bone strength is reduced and fracture healing is impaired. Hematopoiesis appears to be normal. Name=Functional Glycomics Gateway - Glycan Binding; Note=Stem cell growth factor; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_186"; ossification extracellular region extracellular space cytoplasm signal transduction growth factor activity positive regulation of cell proliferation carbohydrate binding uc009gpb.1 uc009gpb.2 uc009gpb.3 uc009gpb.4 
ENSMUST00000004614.15 Zfp110 ENSMUST00000004614.15 zinc finger protein 110, transcript variant 2 (from RefSeq NM_022981.5) A0A0R4J249 A0A0R4J249_MOUSE ENSMUST00000004614.1 ENSMUST00000004614.10 ENSMUST00000004614.11 ENSMUST00000004614.12 ENSMUST00000004614.13 ENSMUST00000004614.14 ENSMUST00000004614.2 ENSMUST00000004614.3 ENSMUST00000004614.4 ENSMUST00000004614.5 ENSMUST00000004614.6 ENSMUST00000004614.7 ENSMUST00000004614.8 ENSMUST00000004614.9 NM_022981 Zfp110 uc009fej.1 uc009fej.2 uc009fej.3 uc009fej.4 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009fej.1 uc009fej.2 uc009fej.3 uc009fej.4 
ENSMUST00000004622.7 Gab2 ENSMUST00000004622.7 growth factor receptor bound protein 2-associated protein 2, transcript variant 1 (from RefSeq NM_010248.2) ENSMUST00000004622.1 ENSMUST00000004622.2 ENSMUST00000004622.3 ENSMUST00000004622.4 ENSMUST00000004622.5 ENSMUST00000004622.6 Gab2 NM_010248 Q3ZB57 Q3ZB57_MOUSE uc009iix.1 uc009iix.2 uc009iix.3 uc009iix.4 Belongs to the GAB family. transmembrane receptor protein tyrosine kinase adaptor activity cytoplasm plasma membrane transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation osteoclast differentiation uc009iix.1 uc009iix.2 uc009iix.3 uc009iix.4 
ENSMUST00000004646.13 Coro1c ENSMUST00000004646.13 coronin, actin binding protein 1C (from RefSeq NM_011779.3) COR1C_MOUSE ENSMUST00000004646.1 ENSMUST00000004646.10 ENSMUST00000004646.11 ENSMUST00000004646.12 ENSMUST00000004646.2 ENSMUST00000004646.3 ENSMUST00000004646.4 ENSMUST00000004646.5 ENSMUST00000004646.6 ENSMUST00000004646.7 ENSMUST00000004646.8 ENSMUST00000004646.9 NM_011779 Q499X7 Q8VCQ5 Q9WUM4 uc008yyu.1 uc008yyu.2 uc008yyu.3 Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (PubMed:27178841). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (PubMed:27178841). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (By similarity). Required for normal distribution of mitochondria within cells (PubMed:27178841). Homotrimer (By similarity). Binds F-actin (PubMed:22364218). Interacts with RCC2 (PubMed:25074804). Interacts preferentially with nucleotide-free and GDP-bound RAC1 (PubMed:25074804). Interacts with VIM (via head domain) (PubMed:27178841). Interacts with MICAL2; this interaction recruits MICAL2 to the actin filaments (By similarity). Cell membrane eripheral membrane protein ytoplasmic side ll projection, lamellipodium ll projection, ruffle membrane Cytoplasm, cytoskeleton toplasm, cell cortex Endosome membrane Note=Colocalizes with the actin cytoskeleton in the cytosol, and especially in the cell cortex (PubMed:19651142, PubMed:22364218, PubMed:25074804, PubMed:27178841). Colocalizes with F-actin at the leading edge of lamellipodia (PubMed:22364218). Partially colocalizes with microtubules and vimentin intermediate filaments (PubMed:27178841). Localizes to endosome membrane tubules/buds (By similarity). Detected in skeletal muscle (at protein level) (PubMed:19651142). Detected in fibroblasts (at protein level) (PubMed:27178841). Ubiquitous (PubMed:9778037). The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization. No visible phenotype (PubMed:27178841). Fibroblasts from mutant mice display a disordered actin cytoskeleton with a reduced width of the actin stress fibers. Likewise, these cells have several microtubule-organizing centers (MTOCs) and a disordered microbutule network (PubMed:27178841). Belongs to the WD repeat coronin family. actin cortical patch assembly neural crest cell migration regulation of protein phosphorylation negative regulation of protein phosphorylation actin binding cytoplasm endosome cytoskeleton plasma membrane cell cortex phagocytosis actin filament organization endosome membrane regulation of epithelial cell migration negative regulation of epithelial cell migration regulation of fibroblast migration actin cytoskeleton membrane endosomal transport lateral plasma membrane cell migration flotillin complex lamellipodium actin cytoskeleton organization vesicle ruffle membrane cell projection negative regulation of protein kinase activity by regulation of protein phosphorylation establishment of protein localization Rac GTPase binding actin filament binding regulation of focal adhesion assembly negative regulation of focal adhesion assembly membrane fission activation of GTPase activity endosome membrane tubulation regulation of substrate adhesion-dependent cell spreading negative regulation of substrate adhesion-dependent cell spreading regulation of ruffle assembly positive regulation of lamellipodium morphogenesis uc008yyu.1 uc008yyu.2 uc008yyu.3 
ENSMUST00000004655.8 Psg17 ENSMUST00000004655.8 pregnancy specific beta-1-glycoprotein 17 (from RefSeq NM_007677.2) CGM5 ENSMUST00000004655.1 ENSMUST00000004655.2 ENSMUST00000004655.3 ENSMUST00000004655.4 ENSMUST00000004655.5 ENSMUST00000004655.6 ENSMUST00000004655.7 NM_007677 Psg17 Q62056 Q62056_MOUSE uc009fjs.1 uc009fjs.2 uc009fjs.3 protein binding immune response female pregnancy heparan sulfate proteoglycan binding uc009fjs.1 uc009fjs.2 uc009fjs.3 
ENSMUST00000004657.14 Psg19 ENSMUST00000004657.14 pregnancy specific beta-1-glycoprotein 19 (from RefSeq NM_011964.2) ENSMUST00000004657.1 ENSMUST00000004657.10 ENSMUST00000004657.11 ENSMUST00000004657.12 ENSMUST00000004657.13 ENSMUST00000004657.2 ENSMUST00000004657.3 ENSMUST00000004657.4 ENSMUST00000004657.5 ENSMUST00000004657.6 ENSMUST00000004657.7 ENSMUST00000004657.8 ENSMUST00000004657.9 NM_011964 Psg19 Q4KL31 Q4KL31_MOUSE uc009fjr.1 uc009fjr.2 uc009fjr.3 uc009fjr.4 molecular_function cellular_component biological_process uc009fjr.1 uc009fjr.2 uc009fjr.3 uc009fjr.4 
ENSMUST00000004673.15 Ndrg2 ENSMUST00000004673.15 N-myc downstream regulated gene 2, transcript variant 1 (from RefSeq NM_013864.3) ENSMUST00000004673.1 ENSMUST00000004673.10 ENSMUST00000004673.11 ENSMUST00000004673.12 ENSMUST00000004673.13 ENSMUST00000004673.14 ENSMUST00000004673.2 ENSMUST00000004673.3 ENSMUST00000004673.4 ENSMUST00000004673.5 ENSMUST00000004673.6 ENSMUST00000004673.7 ENSMUST00000004673.8 ENSMUST00000004673.9 Kiaa1248 NDRG2_MOUSE NM_013864 Ndr2 Q3TI48 Q3TY42 Q3U3T5 Q69ZN2 Q8C661 Q9QYG0 uc007tnk.1 uc007tnk.2 uc007tnk.3 uc007tnk.4 Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). Interacts with CTNNB1. Cytoplasm toplasm, perinuclear region Cell projection, growth cone Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QYG0-1; Sequence=Displayed; Name=2; IsoId=Q9QYG0-2; Sequence=VSP_019009; Expressed at highest levels in brain, heart and liver, and at lower levels in kidney, colon, skeletal muscle, adrenal gland, ovary and uterus (at protein level). Expression is restricted to the developing heart at the stage of 9.5 dpc, and increases after 11.5 dpc as development of tissues and organs proceeds. Present in many developing tissues including heart, brain, lung, liver, gut, kidney, skeletal muscle, cartilage and epidermis (at protein level). Belongs to the NDRG family. negative regulation of cytokine production nucleus cytoplasm Golgi apparatus signal transduction multicellular organism development nervous system development regulation of vascular endothelial growth factor production Wnt signaling pathway cell differentiation growth cone cell projection perinuclear region of cytoplasm negative regulation of smooth muscle cell proliferation negative regulation of ERK1 and ERK2 cascade regulation of platelet-derived growth factor production glutamatergic synapse uc007tnk.1 uc007tnk.2 uc007tnk.3 uc007tnk.4 
ENSMUST00000004681.14 Pnpla6 ENSMUST00000004681.14 patatin-like phospholipase domain containing 6, transcript variant 2 (from RefSeq NM_015801.3) ENSMUST00000004681.1 ENSMUST00000004681.10 ENSMUST00000004681.11 ENSMUST00000004681.12 ENSMUST00000004681.13 ENSMUST00000004681.2 ENSMUST00000004681.3 ENSMUST00000004681.4 ENSMUST00000004681.5 ENSMUST00000004681.6 ENSMUST00000004681.7 ENSMUST00000004681.8 ENSMUST00000004681.9 NM_015801 Nte PLPL6_MOUSE Q3TRM4 Q7TQD6 Q9R114 uc009krr.1 uc009krr.2 Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho) (PubMed:18086666) (Probable). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids. Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (By similarity). Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15178; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphate + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:49092, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57518, ChEBI:CHEBI:57597; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49093; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)- octadecenoate + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40807, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28610, ChEBI:CHEBI:30823; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40808; Evidence=; Reaction=1-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:39959, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:69081; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39960; Evidence=; Reaction=2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:39963, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:75455; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39964; Evidence=; Reaction=1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38488; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38491, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:73990; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38492; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26133; Evidence=; Inhibited by a series a OPs such as mipafox (MPX), phenyl saligenin phosphate (PSP), phenyl dipentyl phosphinate (PDPP), diisopropyl fluorophosphate and paraoxon. pH dependence: Optimum pH is 8.5. ; Endoplasmic reticulum membrane ; Single-pass type III membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3TRM4-1; Sequence=Displayed; Name=2; IsoId=Q3TRM4-2; Sequence=VSP_026390; Name=3; IsoId=Q3TRM4-3; Sequence=VSP_026390, VSP_026391; Name=4; IsoId=Q3TRM4-4; Sequence=VSP_026392, VSP_026393; Expressed in brain, testes and kidney (at protein level) (PubMed:12640454). Expressed ubiquitously in brain of young mice (PubMed:10640712). Reaching adulthood, there is a most prominent expression in Purkinje cells, granule cells and pyramidal neurons of the hippocampus and some large neurons in the medulla oblongata, nucleus dentatus and pons (PubMed:10640712). Expressed in the embryonic respiratory system, different epithelial structures and strongly in the spinal ganglia, during the development. Glycosylated. Embryonically lethal. At 9 dpc, embryos are smaller, and their development is delayed (PubMed:12640454). At 10-11 dpc, the development is arrested with signs of resorption (PubMed:12640454). Heterozygous mice have lower catalytic activity towards the synthetic compound phenyl valerate in the brain and show increased motor activity (PubMed:12640454). Specific chemical modification by some organophosphorus (OP) compounds leads to distal axonopathy in humans and chicken (Probable). The effects of these compounds in mice appear to be less severe (Probable). Mice treated with 1 mg/kg/body weight of ethyl octylphosphonofluoridate (EOPF) have elevated motor activity in the long term (PubMed:12640454). Higher doses result in increased mortality (PubMed:12640454). Belongs to the NTE family. angiogenesis lysophospholipase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process animal organ morphogenesis membrane integral component of membrane lipid catabolic process hydrolase activity phosphatidylcholine metabolic process carboxylic ester hydrolase activity uc009krr.1 uc009krr.2 
ENSMUST00000004683.13 Mcoln1 ENSMUST00000004683.13 mucolipin 1 (from RefSeq NM_053177.1) ENSMUST00000004683.1 ENSMUST00000004683.10 ENSMUST00000004683.11 ENSMUST00000004683.12 ENSMUST00000004683.2 ENSMUST00000004683.3 ENSMUST00000004683.4 ENSMUST00000004683.5 ENSMUST00000004683.6 ENSMUST00000004683.7 ENSMUST00000004683.8 ENSMUST00000004683.9 MCLN1_MOUSE Mcoln1 NM_053177 Q99J21 Trpml1 uc009krq.1 uc009krq.2 uc009krq.3 uc009krq.4 Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis (PubMed:29019981). Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (PubMed:23993788, PubMed:27623384). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events. By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:25733853). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS- induced TFEB activation and autophagy (By similarity). Functions as a Fe(2+) permeable channel in late endosomes and lysosomes. Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (By similarity). In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (PubMed:17050035). May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase. Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671, ChEBI:CHEBI:29108; Evidence=; Channel activity is controlled by multiple regulatory mechanisms in different subcellular compartments (By similarity). Channel function is transiently modulated by changes in Ca(2+), and inhibited by a reduction of pH; pH changes modify the aggregation state of unitary channels; a negative cooperativity between extracellular/lumenal Ca(2+) and H(+) is suggested (PubMed:29019981). Regulated by phosphoinositides in a compartment-specific manner: in lysosomes activated by PtdIns(3,5)P2 (Phosphatidylinositol 3,5- bisphosphate) and at the plasma membrane inhibited by PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) (PubMed:29019981). Homotetramer (PubMed:29019981). Homooligomer. Can heterooligomerize with MCOLN2 or MCOLN3; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific. Interacts with PDCD6. Interacts with TMEM163. Interacts with LAPTM4B (By similarity). Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Cell projection, phagocytic cup Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Delivery from the trans-Golgi to lysosomes seems to occur mainly in a direct intracellular manner without intermediate delivery to the plasma membrane (By similarity). Under normal conditions, restricted to intracellular compartments so that only a very minor proportion is present at the cell membrane (PubMed:29019981). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99J21-1; Sequence=Displayed; Name=2; IsoId=Q99J21-2; Sequence=VSP_010821; Widely expressed, with the highest expression in brain, liver and kidney. Up-regulated by nutrient starvation. The most N-terminal extracellular/lumenal domain (referred to as I-II linker or polycystin-mucolipin domain) contributes to a structure with a four-fold rotational symmetry in a tetrameric assembly; the structure contains a central highly electronegative pore with a 14 A diameter. The pore is critical for Ca(2+) and pH regulation. The protruding structure formed by the I-II linkers may contain all the interaction sites with lipids and proteins in the endolysosomal lumen. Palmitoylated; involved in association with membranes. Phosphorylation by PKA inhibits channel activity. Dephosphorylation increases activity. Proteolytically cleaved probably involving multiple lysosomal proteases including cathepsin B; inhibits lysosomal channel activity. Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN1 sub-subfamily. phagocytic cup adaptive immune response immune system process cation channel activity protein binding lysosome lysosomal membrane endosome late endosome cytosol plasma membrane ion transport calcium ion transport lipid binding membrane integral component of membrane endosomal transport calcium-mediated signaling cytoplasmic vesicle membrane phagocytic vesicle membrane cytoplasmic vesicle late endosome membrane cell projection receptor complex release of sequestered calcium ion into cytosol protein homotetramerization calcium ion transmembrane transport cellular response to calcium ion cellular response to pH NAADP-sensitive calcium-release channel activity autophagosome maturation intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity intracellular vesicle cation transmembrane transport ligand-gated calcium channel activity uc009krq.1 uc009krq.2 uc009krq.3 uc009krq.4 
ENSMUST00000004684.13 Arhgef18 ENSMUST00000004684.13 Rho/Rac guanine nucleotide exchange factor 18, transcript variant 2 (from RefSeq NM_133962.4) ARHGI_MOUSE E9QK59 ENSMUST00000004684.1 ENSMUST00000004684.10 ENSMUST00000004684.11 ENSMUST00000004684.12 ENSMUST00000004684.2 ENSMUST00000004684.3 ENSMUST00000004684.4 ENSMUST00000004684.5 ENSMUST00000004684.6 ENSMUST00000004684.7 ENSMUST00000004684.8 ENSMUST00000004684.9 Kiaa0521 NM_133962 Q6A055 Q6P9R4 Q8BYA4 Q8K227 uc009krj.1 uc009krj.2 uc009krj.3 Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells. Interacts with SEPT9; interaction may inhibit GEF activity. Interacts with Gbetagamma subunits GNB1 and GNG2 (By similarity). Interacts with EPB41L4B. Interacts with PATJ (via C-terminus). Cytoplasm Cytoplasm, cytoskeleton Cell membrane Apical cell membrane Note=In unactivated eosinophils, distributed around the cell periphery in the perimembranous region (By similarity). In activated eosinophils, relocates to the tip of the nucleopod, a membrane structure formed during activation when the nucleus moves to one end of the cell, and is also concentrated in membrane protrusions at the opposite end of the cell (By similarity). Localizes to the apical cell membrane in epithelial cells (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6P9R4-4; Sequence=Displayed; Name=2; IsoId=Q6P9R4-1; Sequence=VSP_059878; Name=3; IsoId=Q6P9R4-2; Sequence=VSP_059878, VSP_059880; Name=4; IsoId=Q6P9R4-3; Sequence=VSP_059878, VSP_059879; guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cytoplasm cytosol cytoskeleton plasma membrane small GTPase mediated signal transduction regulation of cell shape membrane apical plasma membrane actin cytoskeleton organization regulation of Rho protein signal transduction apical part of cell metal ion binding uc009krj.1 uc009krj.2 uc009krj.3 
ENSMUST00000004686.13 Pex11g ENSMUST00000004686.13 peroxisomal biogenesis factor 11 gamma, transcript variant 2 (from RefSeq NM_026951.3) ENSMUST00000004686.1 ENSMUST00000004686.10 ENSMUST00000004686.11 ENSMUST00000004686.12 ENSMUST00000004686.2 ENSMUST00000004686.3 ENSMUST00000004686.4 ENSMUST00000004686.5 ENSMUST00000004686.6 ENSMUST00000004686.7 ENSMUST00000004686.8 ENSMUST00000004686.9 NM_026951 PX11C_MOUSE Pex11c Q6P6M5 Q9D8P0 Q9D8X4 uc009krm.1 uc009krm.2 uc009krm.3 Promotes membrane protrusion and elongation on the peroxisomal surface. Homodimer. Heterodimer with either PEX11A or PEX11B. Interacts with FIS1. Peroxisome membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P6M5-1; Sequence=Displayed; Name=2; IsoId=Q6P6M5-2; Sequence=VSP_013540, VSP_013541; Expressed in liver and at much lower levels in heart, kidney and testis. Belongs to the peroxin-11 family. molecular_function peroxisome peroxisomal membrane integral component of peroxisomal membrane membrane integral component of membrane peroxisome fission intrinsic component of peroxisomal membrane macromolecular complex regulation of peroxisome size uc009krm.1 uc009krm.2 uc009krm.3 
ENSMUST00000004715.2 Mospd2 ENSMUST00000004715.2 motile sperm domain containing 2, transcript variant 1 (from RefSeq NM_029730.4) B1AU74 B1AU74_MOUSE ENSMUST00000004715.1 Mospd2 NM_029730 uc009uvv.1 uc009uvv.2 uc009uvv.3 uc009uvv.4 uc009uvv.5 uc009uvv.6 integral component of plasma membrane membrane integral component of membrane positive regulation of neutrophil chemotaxis positive regulation of monocyte chemotaxis uc009uvv.1 uc009uvv.2 uc009uvv.3 uc009uvv.4 uc009uvv.5 uc009uvv.6 
ENSMUST00000004729.5 Etfb ENSMUST00000004729.5 electron transferring flavoprotein, beta polypeptide, transcript variant 2 (from RefSeq NR_075104.1) ENSMUST00000004729.1 ENSMUST00000004729.2 ENSMUST00000004729.3 ENSMUST00000004729.4 ETFB_MOUSE Etfb NR_075104 Q810V3 Q9DCW4 uc009gmt.1 uc009gmt.2 uc009gmt.3 uc009gmt.4 Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (By similarity). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:25023281). ETFB binds an AMP molecule that probably has a purely structural role (By similarity). Heterodimer composed of ETFA and ETFB. Identified in a complex that contains ETFA, ETFB and ETFRF1. Interacts with ACADM. Mitochondrion matrix The recognition loop recognizes a hydrophobic patch at the surface of interacting dehydrogenases and acts as a static anchor at the interface. Methylated (PubMed:25023281). Trimethylation at Lys-200 and Lys- 203 may negatively regulate the activity in electron transfer from acyl-CoA dehydrogenases. Belongs to the ETF beta-subunit/FixA family. nucleotide binding mitochondrion mitochondrial matrix electron carrier activity mitochondrial electron transfer flavoprotein complex electron transport chain fatty acid beta-oxidation using acyl-CoA dehydrogenase oxidation-reduction process uc009gmt.1 uc009gmt.2 uc009gmt.3 uc009gmt.4 
ENSMUST00000004732.7 Lim2 ENSMUST00000004732.7 lens intrinsic membrane protein 2 (from RefSeq NM_177693.4) ENSMUST00000004732.1 ENSMUST00000004732.2 ENSMUST00000004732.3 ENSMUST00000004732.4 ENSMUST00000004732.5 ENSMUST00000004732.6 LMIP_MOUSE NM_177693 P56563 Q0VEF3 Q3TNV8 Q99PA6 uc009gmp.1 uc009gmp.2 uc009gmp.3 Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. Seems to be associated with itself or another lens membrane component via disulfide bonds. Membrane; Multi-pass membrane protein. Note=Defects in Lim2 are the cause of the cataractous mouse mutant with total opacity of lens 3 (To3). Mice heterozygous or homozygous for the To3 mutation have total opacity of the lens with a dense cataract. In addition, the To3/To3 homozygotes exhibit microphthalmia, abnormally small eyes. Belongs to the PMP-22/EMP/MP20 family. lens development in camera-type eye structural constituent of eye lens plasma membrane bicellular tight junction membrane integral component of membrane vesicle camera-type eye development uc009gmp.1 uc009gmp.2 uc009gmp.3 
ENSMUST00000004756.14 Wwox ENSMUST00000004756.14 WW domain-containing oxidoreductase, transcript variant 1 (from RefSeq NM_019573.4) ENSMUST00000004756.1 ENSMUST00000004756.10 ENSMUST00000004756.11 ENSMUST00000004756.12 ENSMUST00000004756.13 ENSMUST00000004756.2 ENSMUST00000004756.3 ENSMUST00000004756.4 ENSMUST00000004756.5 ENSMUST00000004756.6 ENSMUST00000004756.7 ENSMUST00000004756.8 ENSMUST00000004756.9 NM_019573 Q8C8J6 Q91WL8 Q920Y2 Q9D2B3 Q9D339 Q9JLF5 WWOX_MOUSE Wox1 uc009nod.1 uc009nod.2 uc009nod.3 uc009nod.4 Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity). May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Interacts with TP53, p73/TP73 and MAPK8 (PubMed:11058590, PubMed:12514174). Interacts with MAPT/TAU, RUNX2 and HYAL2 (PubMed:15126504, PubMed:16219768) (By similarity). Forms a ternary complex with TP53 and MDM2 (By similarity). Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. Interacts with TNK2. Interacts with TMEM207 (By similarity). Interacts (via WW domain) with VOPP1 (By similarity). Cytoplasm Nucleus Mitochondrion Golgi apparatus Lysosome Note=Partially localizes to the mitochondria (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Translocates to the nucleus upon genotoxic stress or TNF stimulation (PubMed:11058590). Localized to the lysosome probably upon binding to VOPP1 (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Wox1; IsoId=Q91WL8-1; Sequence=Displayed; Name=2; IsoId=Q91WL8-2; Sequence=VSP_016370, VSP_016371; Name=3; IsoId=Q91WL8-3; Sequence=VSP_016373, VSP_016374; Name=4; IsoId=Q91WL8-4; Sequence=VSP_016372, VSP_016375; Ubiquitous. In the brain, expressed in cortex, striatum, hippocampus and cerebellum (at protein level). Detected in embryonic skeleton, in cranofacial bones, vertebrae and limb bones. Detected in chondrocytes and osteoblasts. Expression starts at 8 dpc in the developing heart. Higher expression in the brain is detected between 12 dpc and 16 dpc. High levels of expression in dorsal root ganglia and spinal nerves were observed throughout all developmental stages. In later developmental stages expression is more prominent in skeletal systems (at protein level). By hyaluronidase. Up-regulated in outer and inner nuclear layers during retinal degeneration. The WW 1 domain mediates interaction with TP73, TFAP2C, LITAF, WBP1 and probably TP53. Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation (By similarity). Ubiquitinated when phosphorylated by TNK2, leading to its degradation. Indistinguishable from wild-type at birth, but die after three weeks due to metabolic syndrome characterized by serum hypoproteinemia, hypoalbuminemia, hypoglycemia, hypocalcemia, hypotriglyceridemia and hypocholesterolemia, growth retardation, decreased bone formation and increased bone resorption. In addition, spontaneous tumor development was observed. Belongs to the short-chain dehydrogenases/reductases (SDR) family. osteoblast differentiation protein binding nucleus cytoplasm mitochondrion Golgi apparatus cytosol plasma membrane microvillus apoptotic process Wnt signaling pathway oxidoreductase activity enzyme binding negative regulation of Wnt signaling pathway positive regulation of transcription from RNA polymerase II promoter skeletal system morphogenesis oxidation-reduction process cellular response to transforming growth factor beta stimulus intrinsic apoptotic signaling pathway by p53 class mediator RNA polymerase II transcription factor complex extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway in absence of ligand transcription coactivator activity uc009nod.1 uc009nod.2 uc009nod.3 uc009nod.4 
ENSMUST00000004770.7 Tyr ENSMUST00000004770.7 tyrosinase, transcript variant 1 (from RefSeq NM_011661.6) ENSMUST00000004770.1 ENSMUST00000004770.2 ENSMUST00000004770.3 ENSMUST00000004770.4 ENSMUST00000004770.5 ENSMUST00000004770.6 NM_011661 Q91XK0 Q91XK0_MOUSE Tyr uc029wmt.1 uc029wmt.2 uc029wmt.3 Reaction=2 5,6-dihydroxyindole-2-carboxylate + O2 = 2 H2O + 2 indole-5,6-quinone-2-carboxylate; Xref=Rhea:RHEA:68388, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16875, ChEBI:CHEBI:177869; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68389; Evidence=; Name=Cu(2+); Xref=ChEBI:CHEBI:29036; Evidence=; Forms an OPN3-dependent complex with DCT in response to blue light in melanocytes. Melanosome membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the tyrosinase family. monophenol monooxygenase activity copper ion binding nucleus cytoplasm cytosol response to UV membrane integral component of membrane oxidoreductase activity response to vitamin D melanin biosynthetic process melanosome intracellular membrane-bounded organelle pigmentation metal ion binding perinuclear region of cytoplasm response to cAMP oxidation-reduction process uc029wmt.1 uc029wmt.2 uc029wmt.3 
ENSMUST00000004774.4 Aqp1 ENSMUST00000004774.4 aquaporin 1 (from RefSeq NM_007472.2) AQP1_MOUSE Aqp1 ENSMUST00000004774.1 ENSMUST00000004774.2 ENSMUST00000004774.3 NM_007472 Q02013 Q542P1 Q91VY8 uc009caq.1 uc009caq.2 uc009caq.3 Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:12133842). Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (By similarity). Homotetramer. Component of the ankyrin-1 complex in the erythrocyte, composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1 (By similarity). Interacts with EPHB2; involved in endolymph production in the inner ear (PubMed:10839360). Identified in a complex with STOM. Interacts (via the N-terminal) with ANK1 (via ANK 1-5 repeats). Interacts (via the C-terminal) with EPB42 (By similarity). Cell membrane ; Multi-pass membrane protein Detected in erythrocytes (at protein level) (PubMed:12133842). In the kidney, expressed on luminal and basal borders of proximal tubules and in the thin limb of Henle's loop (at protein level) (PubMed:31605441). Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Mutant mice are born at the expected Mendelian rate and appear healthy and normal, but display strongly reduced urine osmolality. Besides, their erythrocytes show reduced water permeability. Mice lacking both Aqp1 and Slc14a1 are born at the expected Mendelian ratio, but do not thrive; half of them die within ten days after birth and none are alive after two weeks. Urine osmolality is somewhat lower than that observed with mice lacking only Aqp1. Besides, erythrocyte water permeability is significantly lower than in mice lacking only Aqp1. Pharmacologically inhibited by submillimolar concentrations of mercury. Belongs to the MIP/aquaporin (TC 1.A.8) family. glomerular filtration renal water transport intracellular cGMP activated cation channel activity potassium channel activity water transmembrane transporter activity nucleus cytoplasm plasma membrane integral component of plasma membrane caveola brush border potassium ion transport water transport cell volume homeostasis hyperosmotic response ammonium transmembrane transporter activity response to hormone basal plasma membrane positive regulation of lamellipodium assembly positive regulation of epithelial cell migration potassium ion transmembrane transporter activity glycerol transmembrane transporter activity water channel activity channel activity carbon dioxide transport ammonium transport glycerol transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane sensory perception of pain cellular homeostasis cGMP-mediated signaling symbiont-containing vacuole lateral ventricle development transmembrane transporter activity water homeostasis nitric oxide transmembrane transporter activity nitric oxide transport positive regulation of cell migration axon establishment or maintenance of actin cytoskeleton polarity brush border membrane nuclear membrane dense core granule membrane neuronal cell body membrane secretion by cell secretory granule organization ion transmembrane transport cellular response to UV transepithelial water transport carbon dioxide transmembrane transport carbon dioxide transmembrane transporter activity wound healing sarcolemma response to drug hyperosmotic salinity response identical protein binding neuron projection negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to estrogen axon terminus lipid digestion apical part of cell positive regulation of angiogenesis ephrin receptor binding positive regulation of saliva secretion positive regulation of fibroblast proliferation camera-type eye morphogenesis corticotropin secretion transmembrane transport extracellular exosome renal water absorption cellular response to hydrogen peroxide cellular response to inorganic substance cellular response to mechanical stimulus cellular response to copper ion cellular response to mercury ion cellular response to retinoic acid cellular response to cAMP cellular response to hypoxia cellular response to salt stress cellular hyperosmotic response cellular response to dexamethasone stimulus cellular response to nitric oxide potassium ion transmembrane transport metanephric descending thin limb development metanephric proximal straight tubule development metanephric proximal convoluted tubule segment 2 development metanephric glomerulus vasculature development ammonium transmembrane transport maintenance of symbiont-containing vacuole by host cation transmembrane transport symbiont-containing vacuole membrane uc009caq.1 uc009caq.2 uc009caq.3 
ENSMUST00000004784.11 Cnn2 ENSMUST00000004784.11 calponin 2 (from RefSeq NM_007725.2) Cnn2 ENSMUST00000004784.1 ENSMUST00000004784.10 ENSMUST00000004784.2 ENSMUST00000004784.3 ENSMUST00000004784.4 ENSMUST00000004784.5 ENSMUST00000004784.6 ENSMUST00000004784.7 ENSMUST00000004784.8 ENSMUST00000004784.9 NM_007725 Q543F3 Q543F3_MOUSE uc007gaz.1 uc007gaz.2 uc007gaz.3 Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Belongs to the calponin family. actin binding calmodulin binding cytoskeleton cytoskeleton organization actomyosin structure organization uc007gaz.1 uc007gaz.2 uc007gaz.3 
ENSMUST00000004786.10 Polr2e ENSMUST00000004786.10 polymerase (RNA) II (DNA directed) polypeptide E (from RefSeq NM_025554.2) ENSMUST00000004786.1 ENSMUST00000004786.2 ENSMUST00000004786.3 ENSMUST00000004786.4 ENSMUST00000004786.5 ENSMUST00000004786.6 ENSMUST00000004786.7 ENSMUST00000004786.8 ENSMUST00000004786.9 NM_025554 Polr2e Q80UW8 RPAB1_MOUSE uc007gbi.1 uc007gbi.2 uc007gbi.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity). Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. In RNA Pol II, this subunit is present in 2-fold molar excess over the other subunits. The transcriptionally active Pol III complex consists of a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4- POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92. Interacts with URI1. Nucleus Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family. DNA binding DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm DNA-directed RNA polymerase II, core complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase I complex transcription, DNA-templated transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter transcription from RNA polymerase III promoter RNA polymerase I activity RNA polymerase II activity RNA polymerase III activity uc007gbi.1 uc007gbi.2 uc007gbi.3 
ENSMUST00000004829.13 Cd244a ENSMUST00000004829.13 CD244 molecule A, transcript variant 4 (from RefSeq NR_187116.1) 2b4 CD244_MOUSE Cd244 ENSMUST00000004829.1 ENSMUST00000004829.10 ENSMUST00000004829.11 ENSMUST00000004829.12 ENSMUST00000004829.2 ENSMUST00000004829.3 ENSMUST00000004829.4 ENSMUST00000004829.5 ENSMUST00000004829.6 ENSMUST00000004829.7 ENSMUST00000004829.8 ENSMUST00000004829.9 NR_187116 Nmrk O88654 Q07763 Q3UV86 Q9JIE0 uc007dos.1 uc007dos.2 uc007dos.3 Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:8326140, PubMed:12734329, PubMed:19648922, PubMed:20962259). Activating function implicates association with SH2D1A and FYN. Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2. Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8326140, PubMed:15169881, PubMed:15998796, PubMed:22683124). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (PubMed:15905190). Regulation of NK cell activity by adapters Sh2d1b and Sh2d1b2 is reported conflictingly (PubMed:16127454, PubMed:16425036). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1. At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (By similarity). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD48 provides costimulatory-like function for neighboring T-cells (PubMed:11739483). Inhibits inflammatory responses in dendritic cells (DCs) (PubMed:25643613). Interacts with CD48 (PubMed:9841922, PubMed:15905190). Interacts (via phosphorylated ITSM 1-4) with SH2D1A/SAP (via SH2 domain); SH2D1A probably mediates association with FYN. Interacts (via phosphorylated ITSM 3) with PTPN11/SHP-2, INPP5D/SHIP1, PTPN6/SHP-1 and CSK; binding of SH2D1A prevents association with PTPN11, PTPN6 and CSK. Interacts weakly (via phosphorylated ITSM 2) with PTPN11 and CSK. Interacts with SH2D1B and SH2D1B2. Interacts with MHC class I proteins; the interaction is proposed to prevent self-killing of NK cells (By similarity). Membrane ; Single-pass type I membrane protein Cell membrane Note=Receptor engagement results in a recruitment to lipid drafts essential for the subsequent tyrosine phosphorylation of the ITSMs. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=m2B4L; IsoId=Q07763-1; Sequence=Displayed; Name=2; Synonyms=m2B4S; IsoId=Q07763-2; Sequence=VSP_010401, VSP_010402; Expressed in natural killer (NK) cells, T cells and dendritic cells. The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain- containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3). N-linked glycosylation is essential for the binding to its ligand CD48. Also O-glycosylated, in contrast, O-linked sialylation has a negative impact on ligand binding (By similarity). Phosphorylated by FYN and CSK at tyrosine residues following activation. Coligation with inhibitory receptors such as KIR2DL1 inhibits phosphorylation upon contact of NK cells with sensitive target cells. myeloid dendritic cell activation adaptive immune response natural killer cell activation involved in immune response immune system process protein binding plasma membrane immune response external side of plasma membrane membrane integral component of membrane positive regulation of natural killer cell proliferation signaling receptor activity MHC class I protein binding innate immune response positive regulation of inositol phosphate biosynthetic process positive regulation of granzyme B production positive regulation of interferon-gamma secretion positive regulation of interleukin-8 secretion positive regulation of CD8-positive, alpha-beta T cell proliferation uc007dos.1 uc007dos.2 uc007dos.3 
ENSMUST00000004868.6 Mtfp1 ENSMUST00000004868.6 mitochondrial fission process 1 (from RefSeq NM_026443.4) ENSMUST00000004868.1 ENSMUST00000004868.2 ENSMUST00000004868.3 ENSMUST00000004868.4 ENSMUST00000004868.5 MTFP1_MOUSE Mtp18 NM_026443 Q9CRB8 Q9CZX4 uc007hug.1 uc007hug.2 uc007hug.3 Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function leads to apoptosis (By similarity). Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the MTFP1 family. mitochondrial fission molecular_function mitochondrion mitochondrial inner membrane apoptotic process mitochondrial membrane organization response to muscle activity membrane integral component of membrane uc007hug.1 uc007hug.2 uc007hug.3 
ENSMUST00000004910.12 Eif2b2 ENSMUST00000004910.12 eukaryotic translation initiation factor 2B, subunit 2 beta (from RefSeq NM_145445.4) EI2BB_MOUSE ENSMUST00000004910.1 ENSMUST00000004910.10 ENSMUST00000004910.11 ENSMUST00000004910.2 ENSMUST00000004910.3 ENSMUST00000004910.4 ENSMUST00000004910.5 ENSMUST00000004910.6 ENSMUST00000004910.7 ENSMUST00000004910.8 ENSMUST00000004910.9 NM_145445 Q99LD9 uc007ogr.1 uc007ogr.2 uc007ogr.3 This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. Mutations in the human gene are associated with ovarioleukodystrophy and leukoencephalopathy with vanishing white matter. [provided by RefSeq, Sep 2015]. ##Evidence-Data-START## Transcript exon combination :: AK049731.1, AK076195.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. Activated by the chemical integrated stress response (ISR) inhibitor ISRIB which stimulates guanine nucleotide exchange factor activity for both phosphorylated and unphosphorylated eIF2. Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides. Cytoplasm, cytosol Belongs to the eIF-2B alpha/beta/delta subunits family. ovarian follicle development translation initiation factor activity guanyl-nucleotide exchange factor activity ATP binding GTP binding cytoplasm eukaryotic translation initiation factor 2B complex translation translational initiation regulation of translational initiation central nervous system development response to heat response to glucose oligodendrocyte development axon myelination response to peptide hormone cellular metabolic process positive regulation of axon extension T cell receptor signaling pathway uc007ogr.1 uc007ogr.2 uc007ogr.3 
ENSMUST00000004920.4 Ulk2 ENSMUST00000004920.4 unc-51 like kinase 2 (from RefSeq NM_013881.4) ENSMUST00000004920.1 ENSMUST00000004920.2 ENSMUST00000004920.3 Kiaa0623 NM_013881 Q80TV7 Q9QY01 Q9WTP4 ULK2_MOUSE uc007jih.1 uc007jih.2 uc007jih.3 uc007jih.4 Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Component of a complex consisting of ATG13/KIAA0652, ULK1 and RB1CC1/FIP200. Interacts (via C-terminus) with ATG13/KIAA0652. Associates with the mammalian target of rapamycin complex 1 (mTORC1) through an interaction with RPTOR (By similarity). Interacts with SYNGAP1. Cytoplasmic vesicle membrane ; Peripheral membrane protein Note=Localizes to pre-autophagosomal membrane. Widely expressed. The CTD-like region mediates membrane-binding and incorporation into large protein complexes. Autophosphorylated. In response to nutrient limitation, probably phosphorylated and activated by AMPK, leading to activate autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Sequence=BAC65613.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; autophagosome assembly nucleotide binding pre-autophagosomal structure protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytosol protein phosphorylation autophagy signal transduction nervous system development axonogenesis regulation of autophagy membrane kinase activity phosphorylation transferase activity cytoplasmic vesicle membrane cytoplasmic vesicle pre-autophagosomal structure membrane response to starvation protein autophosphorylation negative regulation of collateral sprouting axon extension autophagy of host cells involved in interaction with symbiont uc007jih.1 uc007jih.2 uc007jih.3 uc007jih.4 
ENSMUST00000004936.10 Ccl24 ENSMUST00000004936.10 C-C motif chemokine ligand 24, transcript variant 1 (from RefSeq NM_019577.5) CCL24_MOUSE Ccl24 ENSMUST00000004936.1 ENSMUST00000004936.2 ENSMUST00000004936.3 ENSMUST00000004936.4 ENSMUST00000004936.5 ENSMUST00000004936.6 ENSMUST00000004936.7 ENSMUST00000004936.8 ENSMUST00000004936.9 NM_019577 Q9JKC0 Scya24 uc008zyn.1 uc008zyn.2 uc008zyn.3 Chemotactic for resting T-lymphocytes, and eosinophils (PubMed:15647285). Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3 (By similarity). Secreted Highest expression in jejunum and spleen. Lower levels found in liver and lung. No expression detected in kidney, thymus, brain or testis. By interleukin-4 and allergen challenge with A.fumigatus (PubMed:11067944). By interleukin-13 (IL13) (PubMed:15647285). No visible phenotype in normal conditions (PubMed:15647285). Mice display a normal base-line eosinophil levels in the hematopoietic tissues and gastrointestinal tract (PubMed:15647285). However, following intratracheal IL13 administration, mice show a profound reduction in airway eosinophilia (PubMed:15647285). Belongs to the intercrine beta (chemokine CC) family. positive regulation of endothelial cell proliferation monocyte chemotaxis cytokine activity extracellular region extracellular space chemotaxis inflammatory response immune response cytoskeleton organization G-protein coupled receptor signaling pathway chemokine activity regulation of cell shape positive regulation of cell migration neutrophil chemotaxis positive regulation of actin filament polymerization CCR3 chemokine receptor binding positive regulation of GTPase activity positive regulation of angiogenesis receptor agonist activity CCR chemokine receptor binding eosinophil chemotaxis lymphocyte chemotaxis positive regulation of inflammatory response chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of eosinophil migration uc008zyn.1 uc008zyn.2 uc008zyn.3 
ENSMUST00000004943.2 Tmed11 ENSMUST00000004943.2 transmembrane p24 trafficking protein 11 (from RefSeq NM_026109.2) ENSMUST00000004943.1 NM_026109 Q9D2R4 TMD11_MOUSE uc008ypd.1 uc008ypd.2 Part of a complex whose function is to bind Ca(2+) to the ER membrane and thereby regulate the retention of ER resident proteins. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Belongs to the EMP24/GP25L family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus intracellular protein transport ER to Golgi vesicle-mediated transport Golgi organization membrane integral component of membrane ER to Golgi transport vesicle uc008ypd.1 uc008ypd.2 
ENSMUST00000004949.8 Traf6 ENSMUST00000004949.8 TNF receptor-associated factor 6, transcript variant 1 (from RefSeq NM_009424.3) ENSMUST00000004949.1 ENSMUST00000004949.2 ENSMUST00000004949.3 ENSMUST00000004949.4 ENSMUST00000004949.5 ENSMUST00000004949.6 ENSMUST00000004949.7 NM_009424 P70196 Q6P9M0 Q8BLV2 TRAF6_MOUSE uc008lhm.1 uc008lhm.2 uc008lhm.3 uc008lhm.4 This gene encodes a member of the TNF receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin ligase activity. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]. E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 (PubMed:15322147, PubMed:17633018). Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity). Leads to the activation of NF-kappa-B and JUN. Seems to also play a role in dendritic cells (DCs) maturation and/or activation (PubMed:14499111). Represses c-Myb-mediated transactivation, in B- lymphocytes (By similarity). Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (PubMed:10421844, PubMed:10215628). Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (PubMed:10421844, PubMed:17092936). Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (PubMed:12881420). Participates also in the TCR signaling by ubiquitinating LAT (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Homotrimer (By similarity). Homooligomer (By similarity). N- terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B- mediated gene expression. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK (By similarity). Associates with NGFR, TNFRSF17, IRAK2, IRAK3, PELI2, PELI3, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Binds UBE2V1. Interacts with MAVS/IPS1. Interacts with TAX1BP1; this interaction mediates deubiquitination of TRAF6 and inhibition of NF-kappa-B activation (By similarity). Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ. Interacts with IL1RL1. Interacts with AJUBA (By similarity). Interacts with TRAFD1. Interacts with TICAM2. Interacts with ZFAND5. Interacts with ARRB1 and ARRB2 (By similarity). Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal) (By similarity). Interacts (via TRAF domains) with DYNC2I2 (via WD domains). Interacts with RBCK1 (By similarity). Interacts with LIMD1 (via LIM domains). Interacts with RSAD2/viperin. Interacts with IFIT3 (via N-terminus) (By similarity). Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain). Interacts with CARD14 (By similarity). Interacts with CD40 and MAP3K8; the interaction is required for ERK activation. Interacts with TICAM1 and this interaction is enhanced in the presence of WDFY1 (By similarity). Interacts with TANK; this interaction increases in response to DNA damage (By similarity). Interacts with USP10; this interaction increases in response to DNA damage (By similarity). Interacts with ZC3H12A; this interaction increases in response to DNA damage and is stimulated by TANK (By similarity). Interacts with WDFY3 (PubMed:27330028). Interacts with TRIM13 (By similarity). Interacts with GPS2 (PubMed:22424771). Interacts (via C-terminus) with SASH1 (By similarity). Interacts with LRRC19 (By similarity). Interacts with IL17RA and TRAF3IP2. Interacts with TOMM70 (By similarity). Interacts with AMBRA1; interaction is required to mediate 'Lys-63'-linked ubiquitination of ULK1 (By similarity). Interacts with CRBN; this interaction inhibits TLR4- mediated signaling by preventing TRAF6-mediated ubiquitination of ECSIT (By similarity). P70196; P27512: Cd40; NbExp=2; IntAct=EBI-448028, EBI-525742; P70196; Q9QZH6: Ecsit; NbExp=5; IntAct=EBI-448028, EBI-527020; P70196; Q9EQY0: Ern1; NbExp=6; IntAct=EBI-448028, EBI-5480799; P70196; P17879: Hspa1b; NbExp=3; IntAct=EBI-448028, EBI-397360; P70196; Q62406-1: Irak1; NbExp=4; IntAct=EBI-448028, EBI-488313; P70196; Q8K4B2: Irak3; NbExp=3; IntAct=EBI-448028, EBI-646179; P70196; Q61084: Map3k3; NbExp=5; IntAct=EBI-448028, EBI-446250; P70196; P22366: Myd88; NbExp=4; IntAct=EBI-448028, EBI-525108; P70196; Q62227: Nr0b2; NbExp=5; IntAct=EBI-448028, EBI-4310440; P70196; P35235: Ptpn11; NbExp=2; IntAct=EBI-448028, EBI-397236; P70196; Q793I8: Tifa; NbExp=2; IntAct=EBI-448028, EBI-524817; P70196; O35305: Tnfrsf11a; NbExp=2; IntAct=EBI-448028, EBI-647362; P70196; Q8C0E5: Traf3ip2; NbExp=3; IntAct=EBI-448028, EBI-530713; P70196; Q8N7N6: Traf3ip2; NbExp=4; IntAct=EBI-448028, EBI-646165; P70196; Q3UDK1: Trafd1; NbExp=2; IntAct=EBI-448028, EBI-1396948; P70196; P62991: Ubc; NbExp=5; IntAct=EBI-448028, EBI-413074; P70196; Q96CG3: TIFA; Xeno; NbExp=4; IntAct=EBI-448028, EBI-740711; Cytoplasm Cytoplasm, cell cortex Nucleus Lipid droplet Note=RSAD2/viperin recruits it to the lipid droplet. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70196-1; Sequence=Displayed; Name=2; IsoId=P70196-2; Sequence=VSP_007404, VSP_007405; Highly expressed in brain, lung, liver, skeletal muscle, and kidney; lower expression in heart, spleen, and testis. The coiled coil domain mediates homo- and hetero- oligomerization. The MATH/TRAF domain binds to receptor cytoplasmic domains. Sumoylated on Lys-124, Lys-142 and Lys-461 with SUMO1. Polyubiquitinated on Lys-124 by TRAF3IP2; after cell stimulation with IL17A (By similarity). Polyubiquitinated; after cell stimulation with IL1B or TGFB. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto- ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This 'Lys-63' site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form. Deubiquitinated by USP10 in a TANK-dependent manner, leading to the negative regulation of NF-kappa-B signaling upon DNA damage. LRRC19 induces 'Lys-63' ubiquitination (PubMed:25026888). Ubiquitinated at Lys-327 by the SCF(FBXL2) complex, leading to its degradation by the proteasome (PubMed:23542741). Abrogation of IL-1-induced activation of NF- kappa-B, MAPK8/JNK and MAPK14/p38. Animals appear normal at birth but become smaller after one week. Show runting, failure of tooth eruption and die after three weeks. Exhibit severe osteopetrosis, thymic atrophy, lymph node deficiency, splenomegaly, and have alopecia and lack sweat glands. Belongs to the TNF receptor-associated factor family. A subfamily. negative regulation of transcription from RNA polymerase II promoter protein polyubiquitination ossification in utero embryonic development neural tube closure immune system process positive regulation of T cell cytokine production ubiquitin-protein transferase activity tumor necrosis factor receptor binding protein binding nucleus cytoplasm lipid particle cytosol plasma membrane cell cortex immune response cellular response to DNA damage stimulus signal transduction I-kappaB kinase/NF-kappaB signaling activation of NF-kappaB-inducing kinase activity JNK cascade zinc ion binding animal organ morphogenesis cytoplasmic side of plasma membrane protein ubiquitination transferase activity cytokine-mediated signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class II protein kinase binding osteoclast differentiation mitogen-activated protein kinase kinase kinase binding ubiquitin conjugating enzyme binding ubiquitin protein ligase binding positive regulation of lipopolysaccharide-mediated signaling pathway thioesterase binding activation of protein kinase activity positive regulation of interleukin-2 production macromolecular complex CD40 receptor complex T-helper 1 type immune response positive regulation of T cell proliferation odontogenesis of dentin-containing tooth identical protein binding histone deacetylase binding regulation of apoptotic process myeloid dendritic cell differentiation regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling protein kinase B binding positive regulation of JUN kinase activity positive regulation of interleukin-12 biosynthetic process positive regulation of interleukin-6 biosynthetic process bone resorption positive regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter bone remodeling metal ion binding protein N-terminus binding cell development perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation T cell receptor signaling pathway regulation of immunoglobulin secretion positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein autoubiquitination ubiquitin protein ligase activity interleukin-1-mediated signaling pathway protein K63-linked ubiquitination response to interleukin-1 cellular response to lipopolysaccharide cellular response to cytokine stimulus positive regulation of NIK/NF-kappaB signaling positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of transcription regulatory region DNA binding uc008lhm.1 uc008lhm.2 uc008lhm.3 uc008lhm.4 
ENSMUST00000004959.3 Grap ENSMUST00000004959.3 GRB2-related adaptor protein (from RefSeq NM_027817.3) ENSMUST00000004959.1 ENSMUST00000004959.2 GRAP_MOUSE Grap NM_027817 Q0VBE3 Q3U545 Q9CX99 uc007jhz.1 uc007jhz.2 uc007jhz.3 Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB (By similarity). Membrane ; Peripheral membrane protein Synapse Note=Localizes at the presynaptic terminal. Expressed in inner ear, in neruonal fibers innervating cochlear and utricular auditory hair cells (at protein level). Belongs to the GRB2/sem-5/DRK family. sensory perception of sound presynapse uc007jhz.1 uc007jhz.2 uc007jhz.3 
ENSMUST00000004965.8 Chmp2b ENSMUST00000004965.8 charged multivesicular body protein 2B (from RefSeq NM_026879.3) CHM2B_MOUSE ENSMUST00000004965.1 ENSMUST00000004965.2 ENSMUST00000004965.3 ENSMUST00000004965.4 ENSMUST00000004965.5 ENSMUST00000004965.6 ENSMUST00000004965.7 NM_026879 Q80UZ4 Q8BJF9 Q9CT65 uc007zqj.1 uc007zqj.2 uc007zqj.3 Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity). Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with CHMP2A. Interacts with VPS4A. Interacts with VPS4B; the interaction is direct (By similarity). Cytoplasm, cytosol Late endosome membrane ; Peripheral membrane protein In brain, it is expressed in all neuronal populations with a relatively enhanced expression in the hippocampus, frontal and temporal lobes and in both granule and Purkinje cells of the cerebellum. Not expressed in astrocytes or oligodendrocytes. Belongs to the SNF7 family. ESCRT III complex cytoplasm lysosome endosome late endosome multivesicular body cytosol plasma membrane nucleus organization endosome organization vacuolar transport mitotic metaphase plate congression regulation of centrosome duplication postsynaptic density protein transport membrane protein domain specific binding late endosome membrane endosome transport via multivesicular body sorting pathway viral budding via host ESCRT complex late endosome to vacuole transport cognition neuron cellular homeostasis glutamatergic synapse regulation of mitotic spindle assembly positive regulation of viral release from host cell uc007zqj.1 uc007zqj.2 uc007zqj.3 
ENSMUST00000004968.11 Plod3 ENSMUST00000004968.11 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (from RefSeq NM_011962.3) ENSMUST00000004968.1 ENSMUST00000004968.10 ENSMUST00000004968.2 ENSMUST00000004968.3 ENSMUST00000004968.4 ENSMUST00000004968.5 ENSMUST00000004968.6 ENSMUST00000004968.7 ENSMUST00000004968.8 ENSMUST00000004968.9 NM_011962 PLOD3_MOUSE Q542E0 Q9CYY9 Q9R0E1 uc009abk.1 uc009abk.2 uc009abk.3 uc009abk.4 Multifunctional enzyme that catalyzes a series of post- translational modifications on Lys residues in procollagen (PubMed:16447251). Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:16447251). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5- hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2- glucosylgalactosyl-5-hydroxylysine residues (PubMed:16447251, PubMed:16467571, PubMed:21220425). Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:25419660). Catalyzes hydroxylation and glycosylation of Lys residues in the ADIPOQ collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:23209641). Essential for normal biosynthesis and secretion of type IV collagens (PubMed:15377789, PubMed:16467571, PubMed:17873278). Essential for normal formation of basement membranes (PubMed:15377789, PubMed:16467571). Reaction=2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L- lysyl-[collagen] + CO2 + succinate; Xref=Rhea:RHEA:16569, Rhea:RHEA- COMP:12751, Rhea:RHEA-COMP:12752, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:133442; EC=1.14.11.4; Evidence=; Reaction=(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP; Xref=Rhea:RHEA:12637, Rhea:RHEA-COMP:12752, Rhea:RHEA- COMP:12753, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:133442, ChEBI:CHEBI:133443; EC=2.4.1.50; Evidence=; Reaction=(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose = (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D- galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP; Xref=Rhea:RHEA:12576, Rhea:RHEA-COMP:12753, Rhea:RHEA-COMP:12754, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885, ChEBI:CHEBI:133443, ChEBI:CHEBI:133452; EC=2.4.1.66; Evidence= Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Homodimer. Rough endoplasmic reticulum Endoplasmic reticulum lumen Endoplasmic reticulum membrane ; Peripheral membrane protein ; Lumenal side Secreted Secreted, extracellular space Note=The majority of the secreted protein is associated with the extracellular matrix. Detected in blood serum, heart, brain, liver, kidney, lung, spleen, muscle and testis (at protein level) (PubMed:16447251). Highly expressed in the heart, lung, liver and testis (PubMed:10429951). Detected in the walls of blood vessels in placenta and embryos. Detected in chondrocytes in embryos at 14.5 dpc and in adults, in adult kidney mesangium and vascular poles of kidney glomeruli (PubMed:15377789). Detected around nerves and in the adrenal gland (PubMed:15377789). Detected in embryos (at protein level) (PubMed:16467571). Ubiquitous and strongly expressed in embryos at 8.5 to 9.5 dpc. Expression becomes more restricted during embryonic development. Highly expressed in head, eye lens and developing bones at 12.5 dpc. Expression in the eye is decreased by 14.5 dpc. Detected in capillaries and in the photoreceptor layer in the adult eye (PubMed:15377789). The N-terminal domain mediates glycosyltransferase activity. The C-terminal domain that mediates lysyl hydroxylase activity is also important for homodimerization. N-glycosylated. Full embryonic lethality. Mutant embryos are much smaller than wild-type by 9.5 dpc, and the majority are dead by 10.5 dpc. At 9.5 dpc, mutant embryos display fragmentation of basement membranes (PubMed:15377789, PubMed:16467571). The majority of the mutant embryos display dilated blood vessels, particularly in the region of the sinus venosus (PubMed:16467571). Mutant embryos display no decrease in global lysyl hydroxylase activity, due to the expression of other lysyl hydroxylases (PubMed:15377789). Mutant embryos display a nearly complete loss of procollagen glucosyltransferase activity (PubMed:15377789, PubMed:16467571). in utero embryonic development endothelial cell morphogenesis catalytic activity iron ion binding extracellular region extracellular space endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane rough endoplasmic reticulum Golgi apparatus trans-Golgi network protein O-linked glycosylation protein localization metabolic process procollagen-lysine 5-dioxygenase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen transferase activity transferase activity, transferring glycosyl groups peptidyl-lysine hydroxylation neural tube development collagen fibril organization L-ascorbic acid binding cellular response to hormone stimulus collagen metabolic process procollagen glucosyltransferase activity vasodilation metal ion binding hydroxylysine biosynthetic process epidermis morphogenesis procollagen galactosyltransferase activity dioxygenase activity oxidation-reduction process lung morphogenesis basement membrane assembly uc009abk.1 uc009abk.2 uc009abk.3 uc009abk.4 
ENSMUST00000004985.11 Brpf3 ENSMUST00000004985.11 bromodomain and PHD finger containing, 3 (from RefSeq NM_001081315.1) A0A3B2WAQ0 B2KF05 BRPF3_MOUSE Brpf3 ENSMUST00000004985.1 ENSMUST00000004985.10 ENSMUST00000004985.2 ENSMUST00000004985.3 ENSMUST00000004985.4 ENSMUST00000004985.5 ENSMUST00000004985.6 ENSMUST00000004985.7 ENSMUST00000004985.8 ENSMUST00000004985.9 NM_001081315 Q3TRM7 uc008brp.1 uc008brp.2 uc008brp.3 Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity. Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys- 14' acetylation (H3K14ac), thereby facilitating the activation of replication origins. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Component of some HBO1 complexes composed of KAT7/HBO1, MEAF6, ING4 or ING5, and BRPF3. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with KAT7/HBO1; the interaction is direct. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B2KF05-1; Sequence=Displayed; Name=2; IsoId=B2KF05-2; Sequence=VSP_060569, VSP_060570; Highly expressed in the adult testis and brain. Widely expressed in embryos at 12.5 dpc. No visible phenotype. Sequence=BAE37001.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function histone H3 acetylation metal ion binding MOZ/MORF histone acetyltransferase complex uc008brp.1 uc008brp.2 uc008brp.3 
ENSMUST00000004994.16 Pax3 ENSMUST00000004994.16 paired box 3, transcript variant 2 (from RefSeq NM_001159520.1) ENSMUST00000004994.1 ENSMUST00000004994.10 ENSMUST00000004994.11 ENSMUST00000004994.12 ENSMUST00000004994.13 ENSMUST00000004994.14 ENSMUST00000004994.15 ENSMUST00000004994.2 ENSMUST00000004994.3 ENSMUST00000004994.4 ENSMUST00000004994.5 ENSMUST00000004994.6 ENSMUST00000004994.7 ENSMUST00000004994.8 ENSMUST00000004994.9 NM_001159520 Pax3 Q8BRF1 Q8BRF1_MOUSE uc007bqc.1 uc007bqc.2 uc007bqc.3 uc007bqc.4 Nucleus Belongs to the paired homeobox family. DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter HMG box domain binding uc007bqc.1 uc007bqc.2 uc007bqc.3 uc007bqc.4 
ENSMUST00000005003.12 Lbr ENSMUST00000005003.12 lamin B receptor, transcript variant 1 (from RefSeq NM_133815.3) ENSMUST00000005003.1 ENSMUST00000005003.10 ENSMUST00000005003.11 ENSMUST00000005003.2 ENSMUST00000005003.3 ENSMUST00000005003.4 ENSMUST00000005003.5 ENSMUST00000005003.6 ENSMUST00000005003.7 ENSMUST00000005003.8 ENSMUST00000005003.9 LBR_MOUSE NM_133815 Q3TSW2 Q3U9G9 Q811V8 Q811V9 Q8BST3 Q8K2Y8 Q8VDM0 Q91YS5 Q91Z27 uc007dxo.1 uc007dxo.2 uc007dxo.3 uc007dxo.4 Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:18785926). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (PubMed:22140257). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (PubMed:22140257). Anchors the lamina and the heterochromatin to the inner nuclear membrane (By similarity). Reaction=5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH = 5alpha- cholest-8-en-3beta-ol + NADP(+); Xref=Rhea:RHEA:46456, ChEBI:CHEBI:15378, ChEBI:CHEBI:16608, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:86131; Evidence=; Reaction=4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH; Xref=Rhea:RHEA:18561, ChEBI:CHEBI:15378, ChEBI:CHEBI:17813, ChEBI:CHEBI:18364, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.70; Evidence=; Reaction=4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH = 4,4- dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+); Xref=Rhea:RHEA:46812, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78904, ChEBI:CHEBI:87044; Evidence=; Steroid biosynthesis; cholesterol biosynthesis. Interacts with CBX5 (By similarity). Interacts with DNA (By similarity). Interaction with DNA is sequence independent with higher affinity for supercoiled and relaxed circular DNA than linear DNA (By similarity). Interacts with lamin B (By similarity). Interacts with CLNK (PubMed:26009488). Interacts with TMEM147; promoting LBR localization to the nucleus inner membrane (By similarity). Nucleus inner membrane ; Multi-pass membrane protein Nucleus Cytoplasm Endoplasmic reticulum membrane Note=Nucleus; nuclear rim. Highly expressed in the testis and lung. Also expressed in the heart, ovary, kidney and liver. Strongly expressed in liver, skin, brain as well as in specific regions of the developing cartilage and bone in embryos. The Tudor domain may not recognize methylation marks, but rather bind unassembled free histone H3. Phosphorylated by CDK1 in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin (By similarity). It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (By similarity). Phosphorylation of LBR and HP1 proteins may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated by SRPK1 (By similarity). In late anaphase LBR is dephosphorylated, probably by PP1 and/or PP2A, allowing reassociation with chromatin (By similarity). Belongs to the ERG4/ERG24 family. DNA binding protein binding nucleus nuclear envelope nuclear inner membrane nuclear pore nuclear lamina cytoplasm endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process nuclear localization sequence binding steroid metabolic process cholesterol metabolic process membrane integral component of membrane sterol biosynthetic process oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor neutrophil differentiation nuclear membrane delta14-sterol reductase activity chaperone binding oxidation-reduction process chromo shadow domain binding NADPH binding uc007dxo.1 uc007dxo.2 uc007dxo.3 uc007dxo.4 
ENSMUST00000005014.9 Hapln2 ENSMUST00000005014.9 hyaluronan and proteoglycan link protein 2 (from RefSeq NM_022031.2) Bral1 ENSMUST00000005014.1 ENSMUST00000005014.2 ENSMUST00000005014.3 ENSMUST00000005014.4 ENSMUST00000005014.5 ENSMUST00000005014.6 ENSMUST00000005014.7 ENSMUST00000005014.8 HPLN2_MOUSE NM_022031 Q9ESM3 uc008ptq.1 uc008ptq.2 uc008ptq.3 uc008ptq.4 Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid. Secreted, extracellular space, extracellular matrix Brain. Predominantly expressed by neurons. Colocalizes with versican V2 in developing and adult cerebellar white matter and at the nodes of Ranvier. Expression starts at postnatal day 20 and increases thereafter. Belongs to the HAPLN family. skeletal system development hyaluronic acid binding extracellular region cell adhesion central nervous system development establishment of blood-nerve barrier extracellular matrix extracellular matrix assembly uc008ptq.1 uc008ptq.2 uc008ptq.3 uc008ptq.4 
ENSMUST00000005015.10 Prcc ENSMUST00000005015.10 papillary renal cell carcinoma (translocation-associated) (from RefSeq NM_033573.2) ENSMUST00000005015.1 ENSMUST00000005015.2 ENSMUST00000005015.3 ENSMUST00000005015.4 ENSMUST00000005015.5 ENSMUST00000005015.6 ENSMUST00000005015.7 ENSMUST00000005015.8 ENSMUST00000005015.9 NM_033573 Prcc Q9EQC8 Q9EQC8_MOUSE uc008ptb.1 uc008ptb.2 uc008ptb.3 uc008ptb.4 molecular_function nucleus mitotic cell cycle checkpoint nuclear speck uc008ptb.1 uc008ptb.2 uc008ptb.3 uc008ptb.4 
ENSMUST00000005016.16 Mettl25b ENSMUST00000005016.16 methyltransferase like 25B (from RefSeq NM_153562.4) ENSMUST00000005016.1 ENSMUST00000005016.10 ENSMUST00000005016.11 ENSMUST00000005016.12 ENSMUST00000005016.13 ENSMUST00000005016.14 ENSMUST00000005016.15 ENSMUST00000005016.2 ENSMUST00000005016.3 ENSMUST00000005016.4 ENSMUST00000005016.5 ENSMUST00000005016.6 ENSMUST00000005016.7 ENSMUST00000005016.8 ENSMUST00000005016.9 G3X8Q8 MT25B_MOUSE Mettl25b NM_153562 Q8BZG5 Q8CII4 Rrnad1 uc008pth.1 uc008pth.2 uc008pth.3 uc008pth.4 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZG5-1; Sequence=Displayed; Name=2; IsoId=Q8BZG5-2; Sequence=VSP_025878, VSP_025879, VSP_025880; Belongs to the METTL25 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008pth.1 uc008pth.2 uc008pth.3 uc008pth.4 
ENSMUST00000005017.15 Hdgf ENSMUST00000005017.15 heparin binding growth factor, transcript variant 1 (from RefSeq NM_008231.5) ENSMUST00000005017.1 ENSMUST00000005017.10 ENSMUST00000005017.11 ENSMUST00000005017.12 ENSMUST00000005017.13 ENSMUST00000005017.14 ENSMUST00000005017.2 ENSMUST00000005017.3 ENSMUST00000005017.4 ENSMUST00000005017.5 ENSMUST00000005017.6 ENSMUST00000005017.7 ENSMUST00000005017.8 ENSMUST00000005017.9 HDGF_MOUSE NM_008231 P51859 Q8BPG7 Q9CYA4 Q9JK87 Tdrm1 uc008ptc.1 uc008ptc.2 uc008ptc.3 Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity). Monomer, and domain-swapped homodimer (By similarity). Interacts with nuclear proteins NCL and YBX1/YB1 (By similarity). P51859; Q3UMU9: Hdgfl2; NbExp=4; IntAct=EBI-2943087, EBI-7627961; P51859; Q3UMU9-1; NbExp=4; IntAct=EBI-2943087, EBI-7627862; P51859; Q3UMU9-3; NbExp=4; IntAct=EBI-2943087, EBI-7627932; Nucleus Cytoplasm Secreted, extracellular exosome Note=Secreted by exosomes and is located inside the exosome (By similarity). May also be secreted as free protein via an as yet unknown pathway (By similarity). Expressed predominantly in testis and skeletal muscle, to intermediate extents in heart, brain, lung, liver, and kidney, and to a minimal extent in spleen. The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal region is essentially unstructured. The N-terminal region does not contain a typical signal sequence but is required for secretion (PubMed:21087088). It also determines exosomal location (By similarity). Sumoylated with SUMO1. Sumoylation prevents binding to chromatin. Phosphorylation at Ser-165 is likely to be required for secretion. Belongs to the HDGF family. negative regulation of transcription from RNA polymerase II promoter nucleotide binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription corepressor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription corepressor activity actin binding protein binding extracellular region extracellular space nucleus nucleoplasm cytoplasm signal transduction growth factor activity heparin binding cellular process tubulin binding transcriptional repressor complex protein localization to nucleus positive regulation of transcription from RNA polymerase II promoter positive regulation of cell division extracellular exosome cellular response to interleukin-7 uc008ptc.1 uc008ptc.2 uc008ptc.3 
ENSMUST00000005019.6 Crabp2 ENSMUST00000005019.6 cellular retinoic acid binding protein II (from RefSeq NM_007759.2) ENSMUST00000005019.1 ENSMUST00000005019.2 ENSMUST00000005019.3 ENSMUST00000005019.4 ENSMUST00000005019.5 NM_007759 P22935 RABP2_MOUSE uc008ptk.1 uc008ptk.2 uc008ptk.3 Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors. Interacts with importin alpha (By similarity). Interacts with RXR and RARA. Cytoplasm Endoplasmic reticulum Nucleus Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Embryo and skin of adult mouse. By retinoic acid. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. retinoic acid binding retinoic acid biosynthetic process nucleus nucleoplasm cytoplasm endoplasmic reticulum cytosol lipid binding retinal binding retinol binding cyclin binding embryonic forelimb morphogenesis retinoic acid metabolic process regulation of retinoic acid receptor signaling pathway positive regulation of collateral sprouting uc008ptk.1 uc008ptk.2 uc008ptk.3 
ENSMUST00000005053.14 Tmem242 ENSMUST00000005053.14 transmembrane protein 242 (from RefSeq NM_027457.4) ENSMUST00000005053.1 ENSMUST00000005053.10 ENSMUST00000005053.11 ENSMUST00000005053.12 ENSMUST00000005053.13 ENSMUST00000005053.2 ENSMUST00000005053.3 ENSMUST00000005053.4 ENSMUST00000005053.5 ENSMUST00000005053.6 ENSMUST00000005053.7 ENSMUST00000005053.8 ENSMUST00000005053.9 NM_027457 Q8C2T2 Q8CEX9 Q8VCR3 Q9CYJ2 Q9D1H4 TM242_MOUSE Tmem242 uc008afa.1 uc008afa.2 uc008afa.3 Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3. Participates in the incorporation of the c-ring into vestigial complexes. Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase. Interacts with the core subunits NDUFAF1, ECSIT and ACAD9 of the MCIA complex. Interacts with ATP5MC3, NDUFC2, TMEM70, MT-ND2 AND MT-ND3. Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VCR3-1; Sequence=Displayed; Name=2; IsoId=Q8VCR3-2; Sequence=VSP_027110; Name=3; IsoId=Q8VCR3-3; Sequence=VSP_027111, VSP_027112; Belongs to the TMEM242 family. Sequence=BAC25272.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008afa.1 uc008afa.2 uc008afa.3 
ENSMUST00000005057.7 Thop1 ENSMUST00000005057.7 thimet oligopeptidase 1 (from RefSeq NM_022653.4) A0A0R4IZY0 A0A0R4IZY0_MOUSE ENSMUST00000005057.1 ENSMUST00000005057.2 ENSMUST00000005057.3 ENSMUST00000005057.4 ENSMUST00000005057.5 ENSMUST00000005057.6 NM_022653 Thop1 uc007gfv.1 uc007gfv.2 uc007gfv.3 uc007gfv.4 Reaction=Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.; EC=3.4.24.15; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion. ; Monomer. Cytoplasm Belongs to the peptidase M3 family. metalloendopeptidase activity proteolysis peptidase activity metallopeptidase activity hydrolase activity peptide binding metal ion binding uc007gfv.1 uc007gfv.2 uc007gfv.3 uc007gfv.4 
ENSMUST00000005064.14 Pias4 ENSMUST00000005064.14 protein inhibitor of activated STAT 4 (from RefSeq NM_021501.4) ENSMUST00000005064.1 ENSMUST00000005064.10 ENSMUST00000005064.11 ENSMUST00000005064.12 ENSMUST00000005064.13 ENSMUST00000005064.2 ENSMUST00000005064.3 ENSMUST00000005064.4 ENSMUST00000005064.5 ENSMUST00000005064.6 ENSMUST00000005064.7 ENSMUST00000005064.8 ENSMUST00000005064.9 NM_021501 PIAS4_MOUSE Piasg Q8R165 Q9JM05 uc007ggc.1 uc007ggc.2 uc007ggc.3 uc007ggc.4 uc007ggc.5 uc007ggc.6 Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (By similarity). Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs) (PubMed:11731474). Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity). Mediates sumoylation of PARP1 in response to PARP1 trapping to chromatin (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein sumoylation. Interacts with AR, AXIN1, GATA2, TP53 and STAT1 (IFNG-induced) (By similarity). Interacts with LEF1 (PubMed:11731474). Interacts with TICAM1 (By similarity). Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase (By similarity). Interacts with MTA1 (By similarity). Interacts with PRDM1/Blimp-1 (By similarity). Interacts with TRIM32 upon treatment with UVB and TNF- alpha (PubMed:16816390). (Microbial infection) Interacts ewith Moloney murine leukemia virus Capsid protein p30. Nucleus, PML body te=Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies. Accumulates in the cytoplasm upon treatment with UVB and TNF-alpha. Widely expressed, with highest levels in testis. Also expressed in vascular endothelial cells, in primary keratinocytes and in the CNS, including cortex, olfactory bulb, spinal cord, thalamus and trigeminal ganglion. Low expression, if any, in liver and lung. At 8.5 dpc, expressed primarily in the anterior part of the neural tube. At 10.5 dpc, expressed in the neuroepithelium of the forebrain and hindbrain. At 11.5 dpc, detected in the neural tube, eye, limb buds and brachial arches. At 12.5 dpc, expressed in the hindlimbs and forelimbs, as well as in the forebrain. At 12.5 and 13.5 dpc, detected in single cells in the marginal zone of the developing cortex, as well as in other developing tissues and organs. At 13.5 dpc, expressed in the developing limb buds, in single cells in the mesenchyme surrounding future digit structures. At 15.5 dpc, detected in the inner root sheath of vibrissa hair follicle. Expression in the inner root sheath of the hair follicle continues later in life as it can also be detected in the back skin of newborn at postnatal day 3. At 16.5 dpc, expressed in the epithelium of olfactory and in the retina. The LXXLL motif is a coregulator signature that is essential for transcriptional corepression. Sumoylated. Lys-35 is the main site of sumoylation. Sumoylation is required for TCF4 sumoylation and transcriptional activation. Represses LEF1 transcriptional activity. SUMO1 is the preferred conjugate. Ubiquitinated by TRIM32 upon treatment with UVB and TNF-alpha. Belongs to the PIAS family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding DNA binding transcription cofactor activity transcription corepressor activity protein binding nucleus nucleoplasm cytoplasm regulation of transcription from RNA polymerase II promoter JAK-STAT cascade multicellular organism development protein C-terminus binding zinc ion binding negative regulation of tumor necrosis factor-mediated signaling pathway viral process Wnt signaling pathway nuclear matrix PML body transferase activity protein sumoylation SUMO transferase activity ubiquitin protein ligase binding negative regulation of NF-kappaB transcription factor activity positive regulation of protein sumoylation negative regulation of transcription, DNA-templated metal ion binding SUMO ligase activity positive regulation of keratinocyte apoptotic process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage transferase complex uc007ggc.1 uc007ggc.2 uc007ggc.3 uc007ggc.4 uc007ggc.5 uc007ggc.6 
ENSMUST00000005066.9 Map2k1 ENSMUST00000005066.9 mitogen-activated protein kinase kinase 1, transcript variant 1 (from RefSeq NM_008927.5) ENSMUST00000005066.1 ENSMUST00000005066.2 ENSMUST00000005066.3 ENSMUST00000005066.4 ENSMUST00000005066.5 ENSMUST00000005066.6 ENSMUST00000005066.7 ENSMUST00000005066.8 Map2k1 NM_008927 Q3TMJ8 Q3TMJ8_MOUSE uc009qbp.1 uc009qbp.2 uc009qbp.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body Nucleus Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. nucleotide binding activation of MAPK activity protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity ATP binding endoplasmic reticulum cytosol plasma membrane protein phosphorylation cell cycle arrest protein C-terminus binding negative regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression kinase activity phosphorylation peptidyl-threonine phosphorylation regulation of protein heterodimerization activity protein serine/threonine kinase activator activity positive regulation of transcription, DNA-templated protein N-terminus binding ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity cellular senescence scaffold protein binding positive regulation of production of miRNAs involved in gene silencing by miRNA uc009qbp.1 uc009qbp.2 uc009qbp.3 
ENSMUST00000005067.6 Sgta ENSMUST00000005067.6 small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha, transcript variant 1 (from RefSeq NM_024499.2) ENSMUST00000005067.1 ENSMUST00000005067.2 ENSMUST00000005067.3 ENSMUST00000005067.4 ENSMUST00000005067.5 NM_024499 Q8BGA6 Q8BJU0 Q99L52 SGTA_MOUSE Sgt uc007gft.1 uc007gft.2 uc007gft.3 Co-chaperone that binds misfolded and hydrophobic patches- containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity. Homodimer (By similarity). Homooligomer (By similarity). Interacts with DNAJC5 and DNAJC5B (PubMed:17034881). Interacts (via TPR repeats) with HSP90AA1. Interacts (via Gln-rich region) with SLC2A1 (By similarity). Interacts with HSP90AB1 (By similarity). Interacts (via TPR repeats) with HSPA8/Hsc70; the interaction is direct (By similarity). Interacts with BAG6 (via ubiquitin-like domain); interaction prevents interaction between BAG6 and RNF126 (By similarity). Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct (By similarity). Cytoplasm Nucleus Note=Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BJU0-1; Sequence=Displayed; Name=2; IsoId=Q8BJU0-2; Sequence=VSP_009300; Belongs to the SGT family. nucleus cytoplasm cytosol posttranslational protein targeting to membrane membrane ER-associated ubiquitin-dependent protein catabolic process identical protein binding protein homodimerization activity protein self-association protein heterodimerization activity chaperone-mediated protein folding tail-anchored membrane protein insertion into ER membrane TRC complex presynapse extrinsic component of synaptic vesicle membrane negative regulation of ER-associated ubiquitin-dependent protein catabolic process positive regulation of ER-associated ubiquitin-dependent protein catabolic process positive regulation of chaperone-mediated protein folding BAT3 complex binding negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc007gft.1 uc007gft.2 uc007gft.3 
ENSMUST00000005069.8 Nmrk2 ENSMUST00000005069.8 nicotinamide riboside kinase 2 (from RefSeq NM_027120.2) ENSMUST00000005069.1 ENSMUST00000005069.2 ENSMUST00000005069.3 ENSMUST00000005069.4 ENSMUST00000005069.5 ENSMUST00000005069.6 ENSMUST00000005069.7 Itgb1bp3 NM_027120 NRK2_MOUSE Nrk2 Q0VEG2 Q3UV96 Q9D7C9 uc007ggn.1 uc007ggn.2 uc007ggn.3 Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis (By similarity). Reaction=ATP + beta-nicotinamide D-riboside = ADP + beta-nicotinamide D-ribonucleotide + H(+); Xref=Rhea:RHEA:14017, ChEBI:CHEBI:14649, ChEBI:CHEBI:15378, ChEBI:CHEBI:15927, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=2.7.1.22; Evidence=; Reaction=ATP + beta-D-ribosylnicotinate = ADP + H(+) + nicotinate beta- D-ribonucleotide; Xref=Rhea:RHEA:25568, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57502, ChEBI:CHEBI:58527, ChEBI:CHEBI:456216; EC=2.7.1.173; Evidence=; Cofactor biosynthesis; NAD(+) biosynthesis. Monomer (By similarity). Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5. Expressed in skeletal muscle (at protein level). Down-regulated during myoblast differentiation. Belongs to the uridine kinase family. NRK subfamily. nucleotide binding protein binding ATP binding nucleoplasm plasma membrane NAD biosynthetic process kinase activity phosphorylation transferase activity pyridine nucleotide biosynthetic process intracellular membrane-bounded organelle negative regulation of myoblast differentiation metal ion binding ribosylnicotinamide kinase activity ribosylnicotinate kinase activity uc007ggn.1 uc007ggn.2 uc007ggn.3 
ENSMUST00000005073.13 Zp3 ENSMUST00000005073.13 zona pellucida glycoprotein 3 (from RefSeq NM_011776.1) ENSMUST00000005073.1 ENSMUST00000005073.10 ENSMUST00000005073.11 ENSMUST00000005073.12 ENSMUST00000005073.2 ENSMUST00000005073.3 ENSMUST00000005073.4 ENSMUST00000005073.5 ENSMUST00000005073.6 ENSMUST00000005073.7 ENSMUST00000005073.8 ENSMUST00000005073.9 NM_011776 P10761 Q4FZI2 ZP3_MOUSE Zp-3 Zpc uc008zzl.1 uc008zzl.2 uc008zzl.3 Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. Polymers of ZP2 and ZP3 organized into long filaments cross- linked by ZP1 homodimers. Interacts with ZP1 and ZP2. [Processed zona pellucida sperm-binding protein 3]: Zona pellucida Cell membrane ; Single-pass type I membrane protein Expressed in oocytes. Expressed during the 2-week growth phase of oogenesis, prior to ovulation. The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida. Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy. Cys-320, Cys-322, Cys-323 and Cys-328 are involved in two additional disulfide bonds. Belongs to the ZP domain family. ZPC subfamily. Name=Protein Spotlight; Note=Molecular chastity - Issue 93 of April 2008; URL="https://web.expasy.org/spotlight/back_issues/093"; positive regulation of type IV hypersensitivity blastocyst formation humoral immune response mediated by circulating immunoglobulin positive regulation of leukocyte migration positive regulation of humoral immune response protein binding extracellular region extracellular space plasma membrane binding of sperm to zona pellucida regulation of receptor activity positive regulation of phosphatidylinositol biosynthetic process membrane integral component of membrane carbohydrate binding acrosin binding positive regulation of interferon-gamma production positive regulation of interleukin-4 production egg coat formation structural constituent of egg coat egg coat positive regulation of T cell proliferation identical protein binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated phosphatidylinositol-mediated signaling receptor agonist activity oocyte development positive regulation of inflammatory response positive regulation of acrosome reaction negative regulation of binding of sperm to zona pellucida positive regulation of acrosomal vesicle exocytosis positive regulation of ovarian follicle development positive regulation of antral ovarian follicle growth uc008zzl.1 uc008zzl.2 uc008zzl.3 
ENSMUST00000005077.7 Hspb1 ENSMUST00000005077.7 heat shock protein 1 (from RefSeq NM_013560.2) ENSMUST00000005077.1 ENSMUST00000005077.2 ENSMUST00000005077.3 ENSMUST00000005077.4 ENSMUST00000005077.5 ENSMUST00000005077.6 Hspb1 NM_013560 Q545F4 Q545F4_MOUSE uc012eeq.1 uc012eeq.2 Cytoplasm, cytoskeleton, spindle Nucleus Belongs to the small heat shock protein (HSP20) family. regulation of protein phosphorylation nucleus cytoplasm response to virus protein kinase binding intracellular signal transduction cellular response to vascular endothelial growth factor stimulus positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway identical protein binding protein homodimerization activity positive regulation of blood vessel endothelial cell migration protein binding involved in protein folding positive regulation of angiogenesis chaperone-mediated protein folding anterograde axonal protein transport axon cytoplasm positive regulation of endothelial cell chemotaxis uc012eeq.1 uc012eeq.2 
ENSMUST00000005103.12 Nfe2l3 ENSMUST00000005103.12 nuclear factor, erythroid derived 2, like 3 (from RefSeq NM_010903.2) ENSMUST00000005103.1 ENSMUST00000005103.10 ENSMUST00000005103.11 ENSMUST00000005103.2 ENSMUST00000005103.3 ENSMUST00000005103.4 ENSMUST00000005103.5 ENSMUST00000005103.6 ENSMUST00000005103.7 ENSMUST00000005103.8 ENSMUST00000005103.9 NF2L3_MOUSE NM_010903 Nrf3 Q9WTM4 uc009bxl.1 uc009bxl.2 Activates erythroid-specific, globin gene expression. Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE). Nucleus High level expression in brain, thymus, testis and placenta. Medium level expression in uterus, stomach and lung. Low level expression in kidney. No expression in heart, liver, spleen and ovary. Belongs to the bZIP family. CNC subfamily. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-templated uc009bxl.1 uc009bxl.2 
ENSMUST00000005108.10 Kdm5a ENSMUST00000005108.10 lysine demethylase 5A (from RefSeq NM_145997.2) ENSMUST00000005108.1 ENSMUST00000005108.2 ENSMUST00000005108.3 ENSMUST00000005108.4 ENSMUST00000005108.5 ENSMUST00000005108.6 ENSMUST00000005108.7 ENSMUST00000005108.8 ENSMUST00000005108.9 Jarid1a KDM5A_MOUSE NM_145997 Q3TM94 Q3UMI5 Q3UXZ9 Q66JZ3 Rbp2 uc009dne.1 uc009dne.2 uc009dne.3 uc009dne.4 Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4' (PubMed:17320161, PubMed:17320163). Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (By similarity). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (PubMed:21960634). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (By similarity). Reaction=3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)- [histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate; Xref=Rhea:RHEA:60208, Rhea:RHEA-COMP:15537, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61961; EC=1.14.11.67; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Interacts with RB1, ESR1, MYC, MYCN and LMO2 (By similarity). Interacts with SUZ12; the interaction is direct (PubMed:20064375). Interacts with BMAL1 and CLOCK (PubMed:21960634). Interacts with HDAC1; this interaction impairs histone deacetylation by HDAC1 (PubMed:21960634). Interacts (via PHD-type 1 zinc finger) with histone H3 unmodified at 'Lys-4' and (via PHD-type 3 zinc finger) with histone H3 di- and trimethylated at 'Lys-4' (By similarity). Q3UXZ9; Q80U70: Suz12; NbExp=2; IntAct=EBI-2531441, EBI-2526494; Nucleus, nucleolus Nucleus te=Occupies promoters of genes involved in RNA metabolism and mitochondrial function. The GSGFP motif is required for the interaction with SUZ12 (PubMed:20064375). The ARID domain specifically binds to the CCGCCC motif and is required for the lysine-specific histone demethylase activity. The PHD-type 3 zinc finger is required for the interaction with histone H3 di- and trimethylated at 'Lys-4' (By similarity). Mice are grossly normal, except that they exhibit behavioral abnormalities when held upside down by the tail, and slight hematological defects. Belongs to the JARID1 histone demethylase family. Sequence=BAE22414.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus nucleolus chromatin organization chromatin remodeling multicellular organism development spermatogenesis zinc ion binding male gonad development oxidoreductase activity chromatin DNA binding histone demethylase activity circadian regulation of gene expression protein-DNA complex histone demethylase activity (H3-trimethyl-K4 specific) histone demethylase activity (H3-dimethyl-K4 specific) histone H3-K4 demethylation histone H3-K4 demethylation, trimethyl-H3-K4-specific methylated histone binding histone methyltransferase complex histone binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated metal ion binding rhythmic process regulation of sequence-specific DNA binding transcription factor activity dioxygenase activity oxidation-reduction process negative regulation of histone deacetylase activity uc009dne.1 uc009dne.2 uc009dne.3 uc009dne.4 
ENSMUST00000005173.11 Sgsh ENSMUST00000005173.11 N-sulfoglucosamine sulfohydrolase (sulfamidase) (from RefSeq NM_018822.3) ENSMUST00000005173.1 ENSMUST00000005173.10 ENSMUST00000005173.2 ENSMUST00000005173.3 ENSMUST00000005173.4 ENSMUST00000005173.5 ENSMUST00000005173.6 ENSMUST00000005173.7 ENSMUST00000005173.8 ENSMUST00000005173.9 NM_018822 Q9EQ08 Q9EQ08_MOUSE Sgsh uc007mql.1 uc007mql.2 uc007mql.3 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Belongs to the sulfatase family. catalytic activity protein binding glycosaminoglycan binding lysosome glycosaminoglycan catabolic process N-acetylglucosamine-6-sulfatase activity sulfuric ester hydrolase activity N-sulfoglucosamine sulfohydrolase activity hydrolase activity heparan sulfate proteoglycan catabolic process heparan sulfate proteoglycan metabolic process uc007mql.1 uc007mql.2 uc007mql.3 
ENSMUST00000005185.8 Cstb ENSMUST00000005185.8 cystatin B (from RefSeq NM_007793.3) CYTB_MOUSE Cst6 ENSMUST00000005185.1 ENSMUST00000005185.2 ENSMUST00000005185.3 ENSMUST00000005185.4 ENSMUST00000005185.5 ENSMUST00000005185.6 ENSMUST00000005185.7 NM_007793 Q3UAW2 Q62426 Stfb uc007fxt.1 uc007fxt.2 uc007fxt.3 This is an intracellular thiol proteinase inhibitor. Cytoplasm. Widely expressed. Highest expression in heart, liver and kidney. Lower levels in brain, lung and skeletal muscle. Lowest levels in spleen and testis. Belongs to the cystatin family. protease binding endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular space nucleus nucleolus cytoplasm cytosol adult locomotory behavior negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity negative regulation of proteolysis uc007fxt.1 uc007fxt.2 uc007fxt.3 
ENSMUST00000005188.14 Sh2b2 ENSMUST00000005188.14 SH2B adaptor protein 2, transcript variant 1 (from RefSeq NM_018825.5) Aps ENSMUST00000005188.1 ENSMUST00000005188.10 ENSMUST00000005188.11 ENSMUST00000005188.12 ENSMUST00000005188.13 ENSMUST00000005188.2 ENSMUST00000005188.3 ENSMUST00000005188.4 ENSMUST00000005188.5 ENSMUST00000005188.6 ENSMUST00000005188.7 ENSMUST00000005188.8 ENSMUST00000005188.9 NM_018825 O88936 Q6PG00 Q9JID9 SH2B2_MOUSE uc009aah.1 uc009aah.2 uc009aah.3 uc009aah.4 Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity). Homodimer. Interacts with KIT/c-KIT, SHC1, EPOR, PDGFR, VAV1 and VAV3. Interacts (via N-terminal region) with SHC1. Interacts (via the phosphorylated C-terminus) with GRB2. Interacts (via its SH2 domain) with EPOR, INSR and KIT. Interacts with GRB2 after B-cell antigen receptor stimulation. Interacts (via PH domain) with VAV3. Interacts with NTRK1, NTRK2 and NTRK3 (phosphorylated); after stimulation of the receptor by its extracellular ligand and subsequent autophosphorylation of the receptor. Binds INSR, GRB2, ASB6 and CAP. Insulin stimulation leads to dissociation of CAP. Binds CBS only when SH2B2/APS has become phosphorylated. INSR binding does not depend on the phosphorylation of SH2B2/APS (By similarity). Q9JID9; Q61851: Fgfr3; NbExp=3; IntAct=EBI-8100899, EBI-6287052; Cytoplasm Cell membrane Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region (By similarity). Strongly expressed in brain; also expressed in spleen, kidney and skeletal muscle, and at low levels in small intestine and bone marrow. Strongly expressed in B-cell lines, but not T-cell lines. Also expressed in myeloid and fibroblast cell lines. Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex. Belongs to the SH2B adapter family. stress fiber ruffle B-1 B cell homeostasis transmembrane receptor protein tyrosine kinase adaptor activity SH3/SH2 adaptor activity protein binding cytoplasm actin filament plasma membrane signal transduction nervous system development insulin receptor signaling pathway positive regulation of signal transduction membrane cytokine-mediated signaling pathway regulation of metabolic process actin cytoskeleton organization intracellular signal transduction signaling adaptor activity glucose homeostasis identical protein binding negative regulation of glucose import regulation of Ras protein signal transduction regulation of immune response antigen receptor-mediated signaling pathway brown fat cell differentiation uc009aah.1 uc009aah.2 uc009aah.3 uc009aah.4 
ENSMUST00000005233.12 Eif2ak4 ENSMUST00000005233.12 eukaryotic translation initiation factor 2 alpha kinase 4, transcript variant 1 (from RefSeq NM_013719.4) A2AUM0 A2AUM0_MOUSE ENSMUST00000005233.1 ENSMUST00000005233.10 ENSMUST00000005233.11 ENSMUST00000005233.2 ENSMUST00000005233.3 ENSMUST00000005233.4 ENSMUST00000005233.5 ENSMUST00000005233.6 ENSMUST00000005233.7 ENSMUST00000005233.8 ENSMUST00000005233.9 Eif2ak4 NM_013719 uc008lrw.1 uc008lrw.2 uc008lrw.3 uc008lrw.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. DNA damage checkpoint nucleotide binding protein kinase activity eukaryotic translation initiation factor 2alpha kinase activity ATP binding protein phosphorylation regulation of translational initiation by eIF2 alpha phosphorylation cellular response to amino acid starvation eiF2alpha phosphorylation in response to endoplasmic reticulum stress regulation of eIF2 alpha phosphorylation by amino acid starvation cellular response to cold uc008lrw.1 uc008lrw.2 uc008lrw.3 uc008lrw.4 
ENSMUST00000005234.13 Wdr1 ENSMUST00000005234.13 WD repeat domain 1 (from RefSeq NM_011715.3) ENSMUST00000005234.1 ENSMUST00000005234.10 ENSMUST00000005234.11 ENSMUST00000005234.12 ENSMUST00000005234.2 ENSMUST00000005234.3 ENSMUST00000005234.4 ENSMUST00000005234.5 ENSMUST00000005234.6 ENSMUST00000005234.7 ENSMUST00000005234.8 ENSMUST00000005234.9 NM_011715 Q3TJY2 Q3TJY2_MOUSE Wdr1 uc033ije.1 uc033ije.2 uc033ije.3 Belongs to the WD repeat AIP1 family. actin filament plasma membrane cell-cell junction cell junction regulation of actin filament depolymerization apical junction assembly maintenance of epithelial cell apical/basal polarity regulation of oligodendrocyte differentiation uc033ije.1 uc033ije.2 uc033ije.3 
ENSMUST00000005255.9 Ccn4 ENSMUST00000005255.9 cellular communication network factor 4, transcript variant 3 (from RefSeq NR_177940.1) Ccn4 ENSMUST00000005255.1 ENSMUST00000005255.2 ENSMUST00000005255.3 ENSMUST00000005255.4 ENSMUST00000005255.5 ENSMUST00000005255.6 ENSMUST00000005255.7 ENSMUST00000005255.8 NR_177940 Q3UFJ5 Q3UFJ5_MOUSE Wisp1 uc007wau.1 uc007wau.2 uc007wau.3 Secreted Belongs to the CCN family. Lacks conserved residue(s) required for the propagation of feature annotation. insulin-like growth factor binding extracellular region extracellular space cytosol positive regulation of osteoblast differentiation regulation of cytokine secretion positive regulation of inflammatory response uc007wau.1 uc007wau.2 uc007wau.3 
ENSMUST00000005256.14 Ndrg1 ENSMUST00000005256.14 N-myc downstream regulated gene 1 (from RefSeq NM_008681.2) ENSMUST00000005256.1 ENSMUST00000005256.10 ENSMUST00000005256.11 ENSMUST00000005256.12 ENSMUST00000005256.13 ENSMUST00000005256.2 ENSMUST00000005256.3 ENSMUST00000005256.4 ENSMUST00000005256.5 ENSMUST00000005256.6 ENSMUST00000005256.7 ENSMUST00000005256.8 ENSMUST00000005256.9 NDRG1_MOUSE NM_008681 Ndr1 Ndrl P97862 Q62433 Tdd5 uc007wax.1 uc007wax.2 uc007wax.3 Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy (By similarity). Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Interacts with RAB4A (membrane-bound form); the interaction involves NDRG1 in vesicular recycling of CDH1. Interacts with APOA1, APOA2, PRA1 and RTN1 (By similarity). Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane (By similarity). Widely expressed, with highest levels in kidney followed by brain, pancreas, small intestine, colon and spleen (at protein level). Also detected in heart and preputial gland, and in much smaller quantities in other tissues. Not detected in duodenum and prostate. Highly expressed in Schwann cells. In early stages of embryo development, expression low when MYCN expression is high. Later, when MYCN levels diminish, levels increase. Repressed by testosterone and also to a lesser extent by dihydrotestosterone. Down-regulated by MYCN. Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent (By similarity). Mutant mice exhibit defects in peripheral nerve development. Initial hind limb weakness developed around age 12 weeks, and significant functional impairment (dragging of hind legs) and muscle atrophy became apparent at age 1 year. After about 5 weeks extensive demyelination of nerve fibers is observed. In later life, large inclusions were seen in the adaxonal Schwann cell cytoplasm. There is no evidence of apoptotic response. Belongs to the NDRG family. nucleus cytoplasm centrosome microtubule organizing center cytosol cytoskeleton microtubule plasma membrane cell-cell adherens junction signal transduction microtubule binding negative regulation of cell proliferation microtubule cytoskeleton membrane Rab GTPase binding DNA damage response, signal transduction by p53 class mediator peripheral nervous system myelin maintenance regulation of cell proliferation gamma-tubulin binding myelin sheath cadherin binding mast cell activation perinuclear region of cytoplasm recycling endosome membrane cellular response to hypoxia glutamatergic synapse uc007wax.1 uc007wax.2 uc007wax.3 
ENSMUST00000005262.2 4930550C14Rik ENSMUST00000005262.2 RIKEN cDNA 4930550C14 gene, transcript variant 1 (from RefSeq NM_029247.4) ENSMUST00000005262.1 MFI_MOUSE Mfi NM_029247 Q3U5F8 Q9D4W2 uc009pmc.1 uc009pmc.2 Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network. Can homodimerize (PubMed:30059978). Interacts with MFF; the interaction inhibits MFF interaction with DNM1L (PubMed:30059978). Cytoplasm, cytosol Mitochondrion outer membrane Note=Predominantly localizes to the cytosol, with a minor fraction at the outer mitochondrial membrane. Enriched in the pancreatic beta cell and the testis and is expressed at low levels in other tissues tested. molecular_function cellular_component biological_process uc009pmc.1 uc009pmc.2 
ENSMUST00000005279.8 Klf5 ENSMUST00000005279.8 Kruppel-like transcription factor 5 (from RefSeq NM_009769.4) Bteb2 ENSMUST00000005279.1 ENSMUST00000005279.2 ENSMUST00000005279.3 ENSMUST00000005279.4 ENSMUST00000005279.5 ENSMUST00000005279.6 ENSMUST00000005279.7 Iklf KLF5_MOUSE NM_009769 Q9JMI2 Q9Z0Z7 uc007uvg.1 uc007uvg.2 uc007uvg.3 uc007uvg.4 Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. Interacts with WWP1. Interacts with ANP32B; this interaction induces promoter region-specific histone incorporation and inhibition of histone acetylation by ANP32B. Q9Z0Z7; Q969H0: FBXW7; Xeno; NbExp=2; IntAct=EBI-647919, EBI-359574; Nucleus. Highest expression in digestive track. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Ubiquitinated (By similarity). Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex Golgi apparatus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription factor binding positive regulation of cell proliferation regulation of gene expression skeletal muscle satellite cell differentiation satellite cell activation involved in skeletal muscle regeneration myotube differentiation involved in skeletal muscle regeneration microvillus assembly regulation of microvillus assembly skeletal muscle cell differentiation intracellular membrane-bounded organelle skeletal muscle tissue regeneration MRF binding sequence-specific DNA binding positive regulation of fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding intestinal epithelial cell development positive regulation of transcription by transcription factor localization cellular response to organic cyclic compound cellular response to peptide positive regulation of pri-miRNA transcription from RNA polymerase II promoter cellular response to leukemia inhibitory factor negative regulation of cardiac vascular smooth muscle cell differentiation uc007uvg.1 uc007uvg.2 uc007uvg.3 uc007uvg.4 
ENSMUST00000005334.3 Shbg ENSMUST00000005334.3 sex hormone binding globulin (from RefSeq NM_011367.2) ENSMUST00000005334.1 ENSMUST00000005334.2 NM_011367 P97497 Q0VB52 SHBG_MOUSE uc007jqp.1 uc007jqp.2 uc007jqp.3 uc007jqp.4 Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity). Homodimer. Secreted Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. steroid binding extracellular region primary spermatocyte growth lipid binding uc007jqp.1 uc007jqp.2 uc007jqp.3 uc007jqp.4 
ENSMUST00000005352.10 Corin ENSMUST00000005352.10 corin, serine peptidase, transcript variant 1 (from RefSeq NM_016869.4) B2RRC6 CORIN_MOUSE Crn ENSMUST00000005352.1 ENSMUST00000005352.2 ENSMUST00000005352.3 ENSMUST00000005352.4 ENSMUST00000005352.5 ENSMUST00000005352.6 ENSMUST00000005352.7 ENSMUST00000005352.8 ENSMUST00000005352.9 Lrp4 NM_016869 Q566K6 Q9Z319 uc008xrj.1 uc008xrj.2 uc008xrj.3 uc008xrj.4 Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) processing (PubMed:11884416, PubMed:15637153). Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation (PubMed:11884416, PubMed:15637153, PubMed:22418978). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (PubMed:20613715, PubMed:22418978). May also process pro-NPPB the B-type natriuretic peptide (By similarity). Cell membrane ; Single-pass type II membrane protein [Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]: Secreted Note=Soluble form produced following cleavage by ADAM10. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=E1a, mE1a; IsoId=Q9Z319-1; Sequence=Displayed; Name=2; Synonyms=E1, mE1; IsoId=Q9Z319-2; Sequence=VSP_043953; Highly expressed in heart. Also expressed in pregnant uterus. N-glycosylated; required for processing and activation. Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1 (By similarity). A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment (By similarity). Mice develop normally, are viable and fertile but develop hypertension. They display increased body weight associated with impaired maturation of pro-NPPA which can be restored by injection of Corin. Spontaneous and salt-sensitive hypertension exacerbated during pregnancy is also noticed. A cardiac hypertrophy is also detected together with a decline in cardiac function later in life (PubMed:15637153). Blood pressure on a high-salt diet is significantly increased: knockout mice show an impairment of urinary sodium excretion and an increase in body weight, but no elevation of plasma renin or serum aldosterone levels (PubMed:22418978). Conditional knockout mice which express Corin in heart only do not display any visible phenotype in non-pregnant mice. In contrast, pregnant conditional knockout mice develop high blood pressure and proteinuria, characteristics of pre- eclampsia. In these mice, trophoblast invasion and uterine spiral artery remodeling are markedly impaired (PubMed:22437503). Corin is disrupted in C57BL/6-Kit(W-sh/W-sh) mice, a genetic inversion used as mast cell-deficient model. Phenotypes in C57BL/6-Kit(W-sh/W-sh) mice are mainly due to the absence of Kit, a receptor for mast cell development. The absence of Corin probably leads to immediate significant cardiac hypertrophy and contractile dysfunction in response to pressure overload (PubMed:21903139). Belongs to the peptidase S1 family. regulation of systemic arterial blood pressure by atrial natriuretic peptide serine-type endopeptidase activity scavenger receptor activity extracellular region plasma membrane integral component of plasma membrane proteolysis endocytosis female pregnancy regulation of blood pressure peptidase activity serine-type peptidase activity cell surface actin cytoskeleton membrane integral component of membrane peptide hormone processing nuclear body hydrolase activity neuron differentiation cytoplasmic vesicle regulation of renal sodium excretion uc008xrj.1 uc008xrj.2 uc008xrj.3 uc008xrj.4 
ENSMUST00000005364.12 G6pc2 ENSMUST00000005364.12 glucose-6-phosphatase, catalytic, 2, transcript variant 1 (from RefSeq NM_021331.4) A2AUN2 ENSMUST00000005364.1 ENSMUST00000005364.10 ENSMUST00000005364.11 ENSMUST00000005364.2 ENSMUST00000005364.3 ENSMUST00000005364.4 ENSMUST00000005364.5 ENSMUST00000005364.6 ENSMUST00000005364.7 ENSMUST00000005364.8 ENSMUST00000005364.9 G6PC2_MOUSE Igrp NM_021331 Q2M2M7 Q9Z186 uc008jxy.1 uc008jxy.2 uc008jxy.3 uc008jxy.4 This gene encodes an enzyme that belongs to the glucose-6-phosphatase catalytic subunit family. Members of this family catalyze the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, to release glucose into the bloodstream. The family member encoded by this gene is found specifically in pancreatic islets but has not been shown to have phosphotransferase or phosphatase activity exhibited by a similar liver enzyme. The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes, an autoimmune disease in which T lymphocytes attack and destroy insulin-producing pancreatic beta cells. In NOD mice, the protein encoded by this gene is a major target of cell-mediated autoimmunity. Variations in the human and mouse genes are associated with lower fasting plasma glucose levels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). Reaction=D-glucose 6-phosphate + H2O = D-glucose + phosphate; Xref=Rhea:RHEA:16689, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:61548; EC=3.1.3.9; Evidence=; Carbohydrate biosynthesis; gluconeogenesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z186-1; Sequence=Displayed; Name=2; IsoId=Q9Z186-2; Sequence=VSP_033650, VSP_033651; Specifically expressed in pancreatic islet cells, in particular those of beta-cell origin. Not detected in testis, kidney, muscle, liver, lung, spleen, brain, pituitary, gastric fundus or heart. Initial onset of expression in the pancreas is at 12 dpc and prominent expression is detected at 14 dpc. Up-regulated in islet cells cultured in hyperglycemic concentrations of glucose. N-glycosylated; the non-glycosylated form is more unstable and is degraded through the proteasome. Mice are no overt anatomical or behavioral phenotype but display a mild metabolic phenotype. Upon fasting those mice exhibit a significant decrease in blood glucose and triacylglycerol compared to wild-type mice. G6pc2 is an autoantigen which is the natural target of a prevalent T-cell population causing insulin-dependent diabetes mellitus through destruction of pancreatic beta cells. Belongs to the glucose-6-phosphatase family. Sequence=AAI11906.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; glucose-6-phosphatase activity endoplasmic reticulum endoplasmic reticulum membrane gluconeogenesis membrane integral component of membrane dephosphorylation hydrolase activity glucose homeostasis regulation of insulin secretion glucose 6-phosphate metabolic process uc008jxy.1 uc008jxy.2 uc008jxy.3 uc008jxy.4 
ENSMUST00000005365.15 Spc25 ENSMUST00000005365.15 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae), transcript variant 3 (from RefSeq NM_001199124.2) ENSMUST00000005365.1 ENSMUST00000005365.10 ENSMUST00000005365.11 ENSMUST00000005365.12 ENSMUST00000005365.13 ENSMUST00000005365.14 ENSMUST00000005365.2 ENSMUST00000005365.3 ENSMUST00000005365.4 ENSMUST00000005365.5 ENSMUST00000005365.6 ENSMUST00000005365.7 ENSMUST00000005365.8 ENSMUST00000005365.9 NM_001199124 Q3UA16 Q9D021 Q9D1K6 SPC25_MOUSE Spbc25 uc008jxw.1 uc008jxw.2 uc008jxw.3 uc008jxw.4 uc008jxw.5 This gene encodes a component of the kinetochore-associated NDC80 protein complex, which is required for the mitotic spindle checkpoint and for microtubule-kinetochore attachment. During meiosis in mouse, the protein localizes to the germinal vesicle and then is associated with the chromosomes following germinal vesicle breakdown. Knockdown of this gene in oocytes results in precocious polar body extrusion, chromosome misalignment and aberrant spindle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end (By similarity). Nucleus Chromosome, centromere, kinetochore Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UA16-1; Sequence=Displayed; Name=2; IsoId=Q3UA16-2; Sequence=VSP_020518; Name=3; IsoId=Q3UA16-3; Sequence=VSP_020519; Belongs to the SPC25 family. chromosome, centromeric region kinetochore condensed chromosome kinetochore molecular_function nucleus chromosome cytosol cell cycle mitotic spindle organization chromosome segregation Ndc80 complex cell division uc008jxw.1 uc008jxw.2 uc008jxw.3 uc008jxw.4 uc008jxw.5 
ENSMUST00000005399.10 Zfp287 ENSMUST00000005399.10 Nucleus (from UniProt Q5SVS9) AF281141 ENSMUST00000005399.1 ENSMUST00000005399.2 ENSMUST00000005399.3 ENSMUST00000005399.4 ENSMUST00000005399.5 ENSMUST00000005399.6 ENSMUST00000005399.7 ENSMUST00000005399.8 ENSMUST00000005399.9 Q5SVS9 Q5SVS9_MOUSE Zfp287 uc287yxm.1 uc287yxm.2 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc287yxm.1 uc287yxm.2 
ENSMUST00000005431.6 Letm1 ENSMUST00000005431.6 leucine zipper-EF-hand containing transmembrane protein 1 (from RefSeq NM_019694.2) ENSMUST00000005431.1 ENSMUST00000005431.2 ENSMUST00000005431.3 ENSMUST00000005431.4 ENSMUST00000005431.5 LETM1_MOUSE Letm1 NM_019694 Q5PQC5 Q7TMK8 Q80ZX6 Q8CGJ3 Q8K5E5 Q9Z2I0 uc008xbi.1 uc008xbi.2 uc008xbi.3 Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:27669901, PubMed:23716663). Mediates proton-dependent calcium efflux from mitochondrion (PubMed:27669901, PubMed:23716663). Functions also as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). Essential for early embryonic development (PubMed:23716663). Reaction=Ca(2+)(in) + 2 H(+)(out) = Ca(2+)(out) + 2 H(+)(in); Xref=Rhea:RHEA:72199, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108; Evidence=; Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out); Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103; Evidence=; Inhibited by ruthenium red or its derivative Ru360. Homohexamer (PubMed:27669901). Interacts with BCS1L (By similarity). Interacts with GHITM (By similarity). Mitochondrion inner membrane ; Single-pass membrane protein PINK1-mediated phosphorylation at Thr-191, positively regulates its mitochondrial calcium transport activity. Knockout Letm1 homozygous mice show embryonic lethality before day E6.5 and around 50% of the heterozygotes die before day E13.5 (PubMed:23716663). Surviving mice show reduced mitochondrial calcium uptake, impaired mitochondrial ATP generation capacity, disrupted early embryonic development, altered glucose metabolism and increased susceptibility to seizures (PubMed:23716663). Belongs to the LETM1 family. Sequence=AAH23862.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH46326.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH55865.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; mitochondrion mitochondrial inner membrane ion transport calcium ion transport mitochondrial calcium ion transport antiporter activity calcium:proton antiporter activity membrane integral component of membrane protein hexamerization cristae formation ribosome binding metal ion binding protein homooligomerization mitochondrial calcium ion homeostasis negative regulation of mitochondrial calcium ion concentration mitochondrial calcium release regulation of cellular hyperosmotic salinity response uc008xbi.1 uc008xbi.2 uc008xbi.3 
ENSMUST00000005452.6 Fgfr4 ENSMUST00000005452.6 fibroblast growth factor receptor 4 (from RefSeq NM_008011.2) A0A0R4IZY3 A0A0R4IZY3_MOUSE ENSMUST00000005452.1 ENSMUST00000005452.2 ENSMUST00000005452.3 ENSMUST00000005452.4 ENSMUST00000005452.5 Fgfr4 NM_008011 uc007qqb.1 uc007qqb.2 uc007qqb.3 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence= Cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum Endosome Membrane ; Single-pass type I membrane protein Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor-activated receptor activity ATP binding endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane cell-cell junction protein phosphorylation heparin binding positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway positive regulation of gene expression regulation of extracellular matrix disassembly membrane integral component of membrane kinase activity phosphorylation cell migration transferase activity fibroblast growth factor binding peptidyl-tyrosine phosphorylation transport vesicle positive regulation of catalytic activity positive regulation of proteolysis protein autophosphorylation positive regulation of ERK1 and ERK2 cascade regulation of bile acid biosynthetic process positive regulation of DNA biosynthetic process uc007qqb.1 uc007qqb.2 uc007qqb.3 
ENSMUST00000005487.12 Txn2 ENSMUST00000005487.12 thioredoxin 2 (from RefSeq NM_019913.5) A2A440 ENSMUST00000005487.1 ENSMUST00000005487.10 ENSMUST00000005487.11 ENSMUST00000005487.2 ENSMUST00000005487.3 ENSMUST00000005487.4 ENSMUST00000005487.5 ENSMUST00000005487.6 ENSMUST00000005487.7 ENSMUST00000005487.8 ENSMUST00000005487.9 NM_019913 P97493 Q545D5 THIOM_MOUSE uc007wog.1 uc007wog.2 uc007wog.3 Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity. Mitochondrion. Belongs to the thioredoxin family. response to hypoxia nucleolus mitochondrion glycerol ether metabolic process response to oxidative stress peptide-methionine (S)-S-oxide reductase activity response to hormone response to glucose response to organic cyclic compound protein disulfide oxidoreductase activity dendrite cellular response to nutrient levels peptide-methionine (R)-S-oxide reductase activity response to drug neuronal cell body macromolecular complex binding cell redox homeostasis response to axon injury oxidation-reduction process uc007wog.1 uc007wog.2 uc007wog.3 
ENSMUST00000005488.9 Casp14 ENSMUST00000005488.9 caspase 14 (from RefSeq NM_009809.5) Casp14 ENSMUST00000005488.1 ENSMUST00000005488.2 ENSMUST00000005488.3 ENSMUST00000005488.4 ENSMUST00000005488.5 ENSMUST00000005488.6 ENSMUST00000005488.7 ENSMUST00000005488.8 NM_009809 Q542Q1 Q542Q1_MOUSE uc007fyd.1 uc007fyd.2 uc007fyd.3 uc007fyd.4 Belongs to the peptidase C14A family. cysteine-type endopeptidase activity nucleus cytoplasm mitochondrion cytosol proteolysis cysteine-type peptidase activity keratin filament cornification uc007fyd.1 uc007fyd.2 uc007fyd.3 uc007fyd.4 
ENSMUST00000005490.10 Slc1a6 ENSMUST00000005490.10 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 (from RefSeq NM_009200.3) EAA4_MOUSE ENSMUST00000005490.1 ENSMUST00000005490.2 ENSMUST00000005490.3 ENSMUST00000005490.4 ENSMUST00000005490.5 ENSMUST00000005490.6 ENSMUST00000005490.7 ENSMUST00000005490.8 ENSMUST00000005490.9 Eaat4 NM_009200 O35544 uc007fyg.1 uc007fyg.2 uc007fyg.3 uc007fyg.4 Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:9379843). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable). Reaction=H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:70699, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29985; Evidence=; Reaction=H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:70851, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29991; Evidence=; Reaction=D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) = D- aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in); Xref=Rhea:RHEA:71379, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29990; Evidence=; Kinetic parameters: KM=40 uM for L-glutamate ; Homotrimer. Cell membrane ; Multi-pass membrane protein Brain specific. Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A6 subfamily. neurotransmitter uptake L-glutamate transmembrane transporter activity high-affinity glutamate transmembrane transporter activity Golgi apparatus plasma membrane integral component of plasma membrane amino acid transport anion transmembrane transporter activity symporter activity L-glutamate transport membrane integral component of membrane regulation of membrane potential intermediate filament cytoskeleton metal ion binding L-glutamate import across plasma membrane glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane uc007fyg.1 uc007fyg.2 uc007fyg.3 uc007fyg.4 
ENSMUST00000005493.14 Slc1a3 ENSMUST00000005493.14 solute carrier family 1 (glial high affinity glutamate transporter), member 3 (from RefSeq NM_148938.3) ENSMUST00000005493.1 ENSMUST00000005493.10 ENSMUST00000005493.11 ENSMUST00000005493.12 ENSMUST00000005493.13 ENSMUST00000005493.2 ENSMUST00000005493.3 ENSMUST00000005493.4 ENSMUST00000005493.5 ENSMUST00000005493.6 ENSMUST00000005493.7 ENSMUST00000005493.8 ENSMUST00000005493.9 NM_148938 Q543U3 Q543U3_MOUSE Slc1a3 uc007vey.1 uc007vey.2 uc007vey.3 uc007vey.4 Reaction=D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) = D- aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in); Xref=Rhea:RHEA:71379, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29990; Evidence=; Reaction=H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:70851, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29991; Evidence=; Reaction=H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:70699, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29985; Evidence=; Cell membrane ; Multi-pass membrane protein Membrane ; Multi- pass membrane protein Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. L-glutamate transmembrane transporter activity high-affinity glutamate transmembrane transporter activity integral component of plasma membrane symporter activity glutamate:sodium symporter activity L-glutamate transport membrane integral component of membrane L-glutamate import D-aspartate import potassium ion transmembrane transport L-glutamate import across plasma membrane chloride transmembrane transport uc007vey.1 uc007vey.2 uc007vey.3 uc007vey.4 
ENSMUST00000005503.5 Msh6 ENSMUST00000005503.5 mutS homolog 6 (from RefSeq NM_010830.2) ENSMUST00000005503.1 ENSMUST00000005503.2 ENSMUST00000005503.3 ENSMUST00000005503.4 Gtmbp MSH6_MOUSE Msh6 NM_010830 O54710 P54276 Q6GTK8 uc008dvd.1 uc008dvd.2 uc008dvd.3 uc008dvd.4 Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction (By similarity). Component of the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1. Heterodimer consisting of MSH2-MSH6 (MutS alpha). Forms a ternary complex with MutL alpha (MLH1- PMS1). Interacts with MCM9. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Nucleus Chromosome Note=Associates with H3K36me3 via its PWWP domain. The PWWP domain specifically recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway. Belongs to the DNA mismatch repair MutS family. nucleotide binding magnesium ion binding four-way junction DNA binding meiotic mismatch repair nuclear chromatin DNA binding chromatin binding damaged DNA binding double-stranded DNA binding ATP binding nucleus nucleoplasm chromosome Golgi apparatus cytosol DNA repair pyrimidine dimer repair mismatch repair cellular response to DNA damage stimulus DNA-dependent ATPase activity determination of adult lifespan intrinsic apoptotic signaling pathway in response to DNA damage response to UV somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments ATPase activity enzyme binding mismatched DNA binding guanine/thymine mispair binding single guanine insertion binding single thymine insertion binding mismatch repair complex MutSalpha complex oxidized purine DNA binding MutLalpha complex binding methylated histone binding interstrand cross-link repair intracellular membrane-bounded organelle ADP binding maintenance of DNA repeat elements isotype switching negative regulation of DNA recombination positive regulation of helicase activity intrinsic apoptotic signaling pathway uc008dvd.1 uc008dvd.2 uc008dvd.3 uc008dvd.4 
ENSMUST00000005507.10 Mlxipl ENSMUST00000005507.10 MLX interacting protein-like, transcript variant 1 (from RefSeq NM_021455.5) ENSMUST00000005507.1 ENSMUST00000005507.2 ENSMUST00000005507.3 ENSMUST00000005507.4 ENSMUST00000005507.5 ENSMUST00000005507.6 ENSMUST00000005507.7 ENSMUST00000005507.8 ENSMUST00000005507.9 MLXPL_MOUSE Mio NM_021455 Q99MY9 Q99MZ0 Q99MZ1 Q99MZ2 Q99MZ3 Q9JLM5 Wbscr14 uc008zxt.1 uc008zxt.2 uc008zxt.3 uc008zxt.4 Transcriptional repressor. Binds to the canonical and non- canonical E box sequences 5'-CACGTG-3'. Binds DNA as a heterodimer with TCFL4/MLX. Nucleus Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Zeta; IsoId=Q99MZ3-1; Sequence=Displayed; Name=2; Synonyms=Theta; IsoId=Q99MZ3-2; Sequence=VSP_002174; Name=3; Synonyms=Iota; IsoId=Q99MZ3-3; Sequence=VSP_002177, VSP_002178; Name=4; Synonyms=Kappa; IsoId=Q99MZ3-4; Sequence=VSP_002179, VSP_002180; Name=5; Synonyms=Eta; IsoId=Q99MZ3-5; Sequence=VSP_002175, VSP_002176; Expressed in the ventricular and intermediate zones of the developing spinal cord of 12.5 dpc embryos. In later embryos expressed in a variety of tissues. Phosphorylation at Ser-566 by AMPK inactivates the DNA-binding activity. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of glycolytic process regulation of transcription from RNA polymerase II promoter transcription factor binding positive regulation of cell proliferation response to glucose glucose mediated signaling pathway protein kinase binding negative regulation of peptidyl-serine phosphorylation carbohydrate response element binding glucose homeostasis sequence-specific DNA binding positive regulation of fatty acid biosynthetic process positive regulation of glycolytic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of lipid biosynthetic process protein heterodimerization activity protein dimerization activity fatty acid homeostasis negative regulation of cell cycle arrest cellular response to glucose stimulus negative regulation of oxidative phosphorylation energy homeostasis uc008zxt.1 uc008zxt.2 uc008zxt.3 uc008zxt.4 
ENSMUST00000005509.11 Stx1a ENSMUST00000005509.11 syntaxin 1A (brain), transcript variant 4 (from RefSeq NR_152855.1) ENSMUST00000005509.1 ENSMUST00000005509.10 ENSMUST00000005509.2 ENSMUST00000005509.3 ENSMUST00000005509.4 ENSMUST00000005509.5 ENSMUST00000005509.6 ENSMUST00000005509.7 ENSMUST00000005509.8 ENSMUST00000005509.9 NR_152855 Q497P1 Q497P1_MOUSE Stx1a uc008zxk.1 uc008zxk.2 uc008zxk.3 Cell membrane Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type IV membrane protein Membrane Belongs to the syntaxin family. SNARE binding positive regulation of neurotransmitter secretion SNAP receptor activity plasma membrane intracellular protein transport voltage-gated potassium channel complex response to gravity positive regulation of norepinephrine secretion postsynaptic density membrane integral component of membrane synaptic vesicle exocytosis synaptic vesicle docking vesicle-mediated transport protein sumoylation myosin binding regulation of exocytosis chloride channel inhibitor activity kinase binding protein domain specific binding secretory granule integral component of synaptic vesicle membrane synaptic vesicle membrane protein binding, bridging SNARE complex synaptic vesicle fusion to presynaptic active zone membrane myosin head/neck binding secretion by cell macromolecular complex positive regulation of catecholamine secretion SNARE complex assembly actomyosin presynaptic membrane identical protein binding neuron projection ATP-dependent protein binding intracellular organelle ion channel binding positive regulation of exocytosis positive regulation of calcium ion-dependent exocytosis protein heterodimerization activity protein N-terminus binding calcium-dependent protein binding synaptic vesicle endocytosis presynaptic active zone membrane synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex synaptobrevin 2-SNAP-25-syntaxin-1a complex protein localization to membrane modulation of excitatory postsynaptic potential glutamatergic synapse integral component of presynaptic membrane uc008zxk.1 uc008zxk.2 uc008zxk.3 
ENSMUST00000005532.9 Nid1 ENSMUST00000005532.9 nidogen 1 (from RefSeq NM_010917.3) ENSMUST00000005532.1 ENSMUST00000005532.2 ENSMUST00000005532.3 ENSMUST00000005532.4 ENSMUST00000005532.5 ENSMUST00000005532.6 ENSMUST00000005532.7 ENSMUST00000005532.8 Ent NID1_MOUSE NM_010917 P10493 Q3TKX9 Q8BQI3 Q8C3U8 Q8C9P6 uc007pmg.1 uc007pmg.2 uc007pmg.3 uc007pmg.4 Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. Interacts with FBLN1 (PubMed:9299350, PubMed:11589703). Interacts with LGALS3BP (PubMed:9501082). Interacts with PLXDC1 (PubMed:16574105). Interacts with SVEP1 (PubMed:36792666). P10493; P02468: Lamc1; NbExp=5; IntAct=EBI-1032117, EBI-7059830; Secreted, extracellular space, extracellular matrix, basement membrane. N- and O-glycosylated. extracellular matrix structural constituent calcium ion binding protein binding collagen binding extracellular region basement membrane extracellular space plasma membrane cell adhesion cell-matrix adhesion positive regulation of cell-substrate adhesion Wnt-protein binding extracellular matrix organization extracellular matrix glomerular basement membrane development Wnt-activated receptor activity receptor complex laminin binding laminin-1 binding proteoglycan binding extracellular matrix binding canonical Wnt signaling pathway cell periphery uc007pmg.1 uc007pmg.2 uc007pmg.3 uc007pmg.4 
ENSMUST00000005548.8 Hmox1 ENSMUST00000005548.8 heme oxygenase 1 (from RefSeq NM_010442.2) ENSMUST00000005548.1 ENSMUST00000005548.2 ENSMUST00000005548.3 ENSMUST00000005548.4 ENSMUST00000005548.5 ENSMUST00000005548.6 ENSMUST00000005548.7 Hmox1 NM_010442 Q3U5U6 Q3U5U6_MOUSE uc009mhc.1 uc009mhc.2 uc009mhc.3 uc009mhc.4 Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Reaction=heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:21764, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17245, ChEBI:CHEBI:29033, ChEBI:CHEBI:57618, ChEBI:CHEBI:57991, ChEBI:CHEBI:58210, ChEBI:CHEBI:60344; EC=1.14.14.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21765; Evidence=; Endoplasmic reticulum membrane ; Single-pass type IV membrane protein ; Cytoplasmic side Belongs to the heme oxygenase family. angiogenesis response to hypoxia wound healing involved in inflammatory response heme oxygenase (decyclizing) activity phospholipase D activity nucleus nucleolus endoplasmic reticulum cytosol caveola heme oxidation cellular iron ion homeostasis response to oxidative stress small GTPase mediated signal transduction regulation of blood pressure cell death negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of muscle cell apoptotic process membrane integral component of membrane enzyme binding heme binding cellular response to nutrient negative regulation of mast cell cytokine production erythrocyte homeostasis cellular response to heat response to nicotine intracellular signal transduction heme catabolic process response to hydrogen peroxide protein homodimerization activity negative regulation of mast cell degranulation negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of neuron apoptotic process regulation of transcription from RNA polymerase II promoter in response to oxidative stress response to estrogen positive regulation of angiogenesis metal ion binding perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation regulation of sequence-specific DNA binding transcription factor activity protein homooligomerization iron ion homeostasis oxidation-reduction process cellular response to hypoxia positive regulation of cell migration involved in sprouting angiogenesis liver regeneration negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of epithelial cell apoptotic process negative regulation of vascular smooth muscle cell proliferation uc009mhc.1 uc009mhc.2 uc009mhc.3 uc009mhc.4 
ENSMUST00000005583.12 Pafah1b3 ENSMUST00000005583.12 platelet-activating factor acetylhydrolase, isoform 1b, subunit 3, transcript variant 4 (from RefSeq NR_184416.1) ENSMUST00000005583.1 ENSMUST00000005583.10 ENSMUST00000005583.11 ENSMUST00000005583.2 ENSMUST00000005583.3 ENSMUST00000005583.4 ENSMUST00000005583.5 ENSMUST00000005583.6 ENSMUST00000005583.7 ENSMUST00000005583.8 ENSMUST00000005583.9 NR_184416 PA1B3_MOUSE Pafah1b3 Pafahg Q61205 uc009fsf.1 uc009fsf.2 uc009fsf.3 Alpha1 catalytic subunit of the cytosolic type I platelet- activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain. Reaction=a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O- alkyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:17777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707; EC=3.1.1.47; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17778; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1- O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:40479, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:44811, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40480; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-O- hexadecyl-sn-glycero-3-phosphate + acetate + H(+); Xref=Rhea:RHEA:41704, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:77580, ChEBI:CHEBI:78385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41705; Evidence=; Beta subunit (PAFAH1B1) inhibits the acetylhydrolase activity of the alpha1/alpha1 catalytic homodimer. Forms a catalytic dimer which is either homodimer (alpha1/alpha1 homodimer) or heterodimer with PAFAH1B2 (alpha1/alpha2 heterodimer). Component of the cytosolic (PAF-AH (I)) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity (By similarity). Interacts with VLDLR; this interaction may modulate the Reelin pathway (PubMed:17330141). Q61205; P63005: Pafah1b1; NbExp=2; IntAct=EBI-1007637, EBI-917499; Cytoplasm. Expressed already by the time of neurulation. By 10.5 dpc, expression is abundant in the developing central and peripheral nervous systems. Major sites include the neuroepithelium of the fore-, mid-, and hindbrain, the spinal cord, the dorsal root, and cranial ganglia. In adult brain, expression is greatly diminished. Knockout mice which are homozygous for the PAFAH1B2 gene appear developmentally normal, and are born at the expected Mendelian rate. Mice have normal fertility and normal spermatogenesis. Double mutant female mice which are homozygous for PAFAH1B2 and PAFAH1B3 are grossly normal and fertile, whereas double- mutant males are infertile. Double mutan mice manifest an earlier disturbance of spermatogenesis with an onset at preleptotene or leptotene stages of meiosis. Originally the subunits of the type I platelet- activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity). Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily. 1-alkyl-2-acetylglycerophosphocholine esterase activity protein binding cytoplasm cytosol lipid metabolic process spermatogenesis brain development lipid catabolic process hydrolase activity identical protein binding protein heterodimerization activity platelet-activating factor acetyltransferase activity uc009fsf.1 uc009fsf.2 uc009fsf.3 
ENSMUST00000005592.7 Siglecg ENSMUST00000005592.7 sialic acid binding Ig-like lectin G, transcript variant 3 (from RefSeq NR_175813.1) ENSMUST00000005592.1 ENSMUST00000005592.2 ENSMUST00000005592.3 ENSMUST00000005592.4 ENSMUST00000005592.5 ENSMUST00000005592.6 NR_175813 Q80ZE3 SIG10_MOUSE Siglec10 uc009gmo.1 uc009gmo.2 uc009gmo.3 Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (PubMed:20038598). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (By similarity). Involved in negative regulation of B-cell antigen receptor signaling and specifically acts on B1 cells to inhibit Ca(2+) signaling, cellular expansion and antibody secretion (PubMed:17572677). The inhibition of B cell activation is dependent on PTPN6/SHP-1 (PubMed:23836061). In association with CD24 may be involved in the selective suppression of the immune response to danger- associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (PubMed:19264983). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (By similarity). Plays a role in the control of autoimmunity (PubMed:20200274). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (PubMed:27548433). (Microbial infection) During infection by RNA viruses inhibits RIG-I signaling in macrophages by promoting its CBL-dependent ubiquitination and degradation via PTPN11/SHP-2. Interacts with PTPN6/SHP-1 upon phosphorylation. Interacts with NCF1 (PubMed:27548433). Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with HMGB1; the interaction is dependent on CD24 (PubMed:19264983). Associates with membrane IgM on the B cell surface (PubMed:24790146). Interacts with RIGI, CBL and PTPN11 (PubMed:23374343). Q80ZE3; Q6Q899: Rigi; NbExp=7; IntAct=EBI-6841023, EBI-6841237; Cell membrane ; Single-pass type I membrane protein. Expressed in B cells with high levels in pre-B cells and B1a cells of the peritoneal cavity. Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Phosphorylation of Tyr-659 is involved in binding to PTPN6. Cd22/Siglec10 double-deficient mice develop autoimmune disease, which is not observed in single-deficient mice. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. hematopoietic progenitor cell differentiation adaptive immune response immune system process protein binding plasma membrane cell adhesion membrane integral component of membrane phosphatase binding carbohydrate binding regulation of B cell proliferation SH2 domain binding innate immune response regulation of immune response negative regulation of calcium-mediated signaling negative regulation of immunoglobulin secretion uc009gmo.1 uc009gmo.2 uc009gmo.3 
ENSMUST00000005600.6 Rfx1 ENSMUST00000005600.6 regulatory factor X, 1 (influences HLA class II expression) (from RefSeq NM_009055.4) ENSMUST00000005600.1 ENSMUST00000005600.2 ENSMUST00000005600.3 ENSMUST00000005600.4 ENSMUST00000005600.5 NM_009055 P48377 Q6PGH8 RFX1_MOUSE uc009mlv.1 uc009mlv.2 uc009mlv.3 Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes (By similarity). Homodimer; binds DNA as a homodimer (By similarity). Heterodimer; heterodimerizes with RFX2 and RFX3 (PubMed:15229132). Nucleus Belongs to the RFX family. RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter intracellular membrane-bounded organelle uc009mlv.1 uc009mlv.2 uc009mlv.3 
ENSMUST00000005601.9 Il27ra ENSMUST00000005601.9 interleukin 27 receptor, alpha, transcript variant 1 (from RefSeq NM_016671.4) E9QNY4 ENSMUST00000005601.1 ENSMUST00000005601.2 ENSMUST00000005601.3 ENSMUST00000005601.4 ENSMUST00000005601.5 ENSMUST00000005601.6 ENSMUST00000005601.7 ENSMUST00000005601.8 I27RA_MOUSE NM_016671 O70394 Tccr Wsx1 uc009mlr.1 uc009mlr.2 uc009mlr.3 uc009mlr.4 Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. Membrane; Single-pass type I membrane protein. Expressed in CD4+ and CD8+ T-cells, B-cells, natural killer cells and macrophages. Highest levels in CD4+ T-cells and natural killer cells. Expression highest in Th0 cells. Down-regulated on differentiation of CD4+ T-cells in both Th1 and TH2 cells. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Belongs to the type I cytokine receptor family. Type 2 subfamily. negative regulation of cellular extravasation positive regulation of T-helper 1 type immune response negative regulation of type 2 immune response cytokine receptor activity protein binding extracellular region cytoplasm plasma membrane external side of plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway cytokine binding positive regulation of interferon-gamma production positive regulation of tyrosine phosphorylation of STAT protein receptor complex interleukin-27 receptor activity regulation of isotype switching to IgG isotypes defense response to Gram-positive bacterium interleukin-27-mediated signaling pathway negative regulation of interleukin-6 secretion negative regulation of tumor necrosis factor secretion negative regulation of interleukin-17 secretion negative regulation of T-helper 17 type immune response negative regulation of T cell extravasation uc009mlr.1 uc009mlr.2 uc009mlr.3 uc009mlr.4 
ENSMUST00000005606.8 Prkaca ENSMUST00000005606.8 protein kinase, cAMP dependent, catalytic, alpha, transcript variant 1 (from RefSeq NM_008854.5) ENSMUST00000005606.1 ENSMUST00000005606.2 ENSMUST00000005606.3 ENSMUST00000005606.4 ENSMUST00000005606.5 ENSMUST00000005606.6 ENSMUST00000005606.7 KAPCA_MOUSE NM_008854 P05132 Pkaca Q9JID0 uc009mll.1 uc009mll.2 uc009mll.3 uc009mll.4 uc009mll.5 uc009mll.6 This gene encodes a member of the serine/threonine protein kinase family. The holoenzyme, protein kinase A (also known as cyclic-AMP dependent protein kinase), mediates cellular response to changes in cyclic-AMP levels. This gene encodes the alpha catalytic subunit of protein kinase A. Protein kinase A-mediated signaling is transduced via phosphorylation of target proteins, and is important for many cellular functions, including mammalian sperm maturation and motility. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Apr 2013]. Phosphorylates a large number of substrates in the cytoplasm and the nucleus (By similarity). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:10805756, PubMed:19223768). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity). RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (By similarity). Involved in chondrogenesis by mediating phosphorylation of SOX9 (PubMed:10805756). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa- B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (PubMed:33886552). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (PubMed:33886552). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (By similarity). Prevents meiosis resumption in prophase- arrested oocytes via CDC25B inactivation by phosphorylation (PubMed:19223768). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (By similarity). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (By similarity). [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.11; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.11; Evidence= Allosterically activated by various compounds, including ATP. Activated by cAMP; the nucleotide acts as a dynamic and allosteric activator by coupling the two lobes of apo PKA, enhancing the enzyme dynamics synchronously and priming it for catalysis. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. Protein kinase A holoenzyme is comprised of two catalytic (C) and two regulatory (R) subunits which keep the enzyme in an inhibited state before activation by cyclic-AMP. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2. Both isoforms 1 and 2 forms activate cAMP-sensitive PKAI and PKAII holoenzymes by interacting with regulatory subunit (R) of PKA, PRKAR1A/PKR1 and PRKAR2A/PKR2, respectively. Interacts with PRKAR1A and PRKAR2B (By similarity). Interacts with NFKB1, NFKB2 and NFKBIA in platelets; these interactions are disrupted by thrombin and collagen. Binds to ABL1 in spermatozoa and with CDC25B in oocytes. Interacts with APOBEC3G and AICDA (By similarity). Interacts with RAB13; downstream effector of RAB13 involved in tight junction assembly (By similarity). Found in a complex at least composed of MROH2B isoform 2, PRKACA isoform 2 and TCP11 (PubMed:27105888). Interacts with MROH2B isoform 2 (PubMed:27105888). Interacts with HSF1 (By similarity). Isoform 2 interacts with TCP11 (PubMed:27105888). Interacts with TBC1D31; in the regulation of OFD1 (By similarity). Interacts in free form with SMO (via C-terminus); the interaction leads to sequestration of PRKACA at the membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors (PubMed:33886552). P05132; P63248: Pkia; NbExp=4; IntAct=EBI-400564, EBI-2931786; P05132; P61014: Pln; NbExp=2; IntAct=EBI-400564, EBI-10148373; P05132; P31324: Prkar2b; NbExp=15; IntAct=EBI-400564, EBI-455340; P05132; P39717: GPB2; Xeno; NbExp=2; IntAct=EBI-400564, EBI-20711; P05132; P00514: PRKAR1A; Xeno; NbExp=6; IntAct=EBI-400564, EBI-1041635; Cytoplasm Cell membrane Nucleus Mitochondrion Membrane ; Lipid-anchor Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes. Colocalizes with HSF1 in nuclear stress bodies (nSBs) upon heat shock (By similarity). Recruited to the cell membrane through interaction with SMO (PubMed:33886552). [Isoform 2]: Cell projection, cilium, flagellum Cytoplasmic vesicle, secretory vesicle, acrosome Note=Expressed in the midpiece region of the sperm flagellum (By similarity). Colocalizes with MROH2B and TCP11 on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm (PubMed:27105888). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=C-alpha-1; IsoId=P05132-1; Sequence=Displayed; Name=2; Synonyms=C-alpha-2, C-alpha-S, C(s); IsoId=P05132-2; Sequence=VSP_004760; [Isoform 2]: Sperm-specific. Accumulates in oocytes before fertilization but fades out after fertilization. Autophosphorylated; phosphorylation is enhanced by vitamin K(2) (By similarity). Phosphorylated on threonine and serine residues. Phosphorylation on Thr-198 is required for full activity (PubMed:8395513, PubMed:9707564). Phosphorylated at Tyr-331 by activated receptor tyrosine kinases EGFR and PDGFR; this increases catalytic efficiency (PubMed:21866565). Asn-3 is partially deaminated to Asp-3 giving rise to 2 major isoelectric variants, called CB and CA respectively. When myristoylated, Ser-11 is autophosphorylated probably in conjunction with deamidation of Asn-3. Frequent early postnatal lethality. Survivals are runted accompanied with mature sperm exhibiting defective forward motility. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. nucleotide binding magnesium ion binding acrosomal vesicle mesoderm formation neural tube closure protein kinase activity protein serine/threonine kinase activity cAMP-dependent protein kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm mitochondrion Golgi apparatus centrosome cytosol plasma membrane cilium axoneme cAMP-dependent protein kinase complex mRNA processing protein phosphorylation positive regulation of cell proliferation protein kinase A signaling membrane kinase activity phosphorylation nuclear speck transferase activity Rab GTPase binding peptidyl-serine phosphorylation peptidyl-threonine phosphorylation protein kinase binding protein domain specific binding manganese ion binding cytoplasmic vesicle motile cilium nucleotide-activated protein kinase complex neuromuscular junction ubiquitin protein ligase binding macromolecular complex protein kinase A regulatory subunit binding cellular response to heat sperm flagellum cell projection neuron projection dendritic spine regulation of cellular respiration plasma membrane raft macromolecular complex binding intercellular bridge regulation of osteoblast differentiation protein autophosphorylation positive regulation of protein export from nucleus sperm capacitation perinuclear region of cytoplasm modulation of synaptic transmission negative regulation of meiotic cell cycle regulation of synaptic transmission, glutamatergic regulation of proteasomal protein catabolic process regulation of protein processing positive regulation of cell cycle arrest cellular response to glucose stimulus cellular response to parathyroid hormone stimulus sperm midpiece ciliary base negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning regulation of bicellular tight junction assembly uc009mll.1 uc009mll.2 uc009mll.3 uc009mll.4 uc009mll.5 uc009mll.6 
ENSMUST00000005607.9 Asf1b ENSMUST00000005607.9 anti-silencing function 1B histone chaperone (from RefSeq NM_024184.2) ASF1B_MOUSE Asf1b ENSMUST00000005607.1 ENSMUST00000005607.2 ENSMUST00000005607.3 ENSMUST00000005607.4 ENSMUST00000005607.5 ENSMUST00000005607.6 ENSMUST00000005607.7 ENSMUST00000005607.8 NM_024184 Q8BP41 Q9CTX3 Q9DAP7 uc009mlk.1 uc009mlk.2 uc009mlk.3 Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:12842904, PubMed:17054786). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (By similarity). Also involved in the nuclear import of the histone H3- H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5ac and H4K12ac) marks in the cytosol (By similarity). Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (By similarity). Required for gonad development (PubMed:26850882). Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4 (By similarity). Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex (By similarity). Interacts with HAT1, NASP and TAF1 (By similarity). Interacts with CDAN1. Found in a cytosolic complex with CDAN1, ASF1A, IPO4 and histones H3.1 and H4 (By similarity). Interacts with CREBBP (By similarity). Nucleus Cytoplasm, cytosol Highly expressed in germ cells (PubMed:26850882). Restricted to premeiotic to meiotic stages during spermatogenesis (PubMed:12842904). Expressed in early embryos and germ cells. Phosphorylated by TLK2 (By similarity). Phosphorylated by TLK1 (PubMed:17054786). Mice are viable but display subfertility caused by altered gamete formation (PubMed:26850882). The timing of meiotic entry and the subsequent gonad development is more severely impaired in female than in male mice (PubMed:26850882). Increased perinatal lethality is also increased in the offspring of knockout females (PubMed:26850882). Belongs to the ASF1 family. chromatin nuclear chromatin blastocyst hatching nucleus nucleoplasm chromatin organization chromatin assembly or disassembly nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly macromolecular complex histone binding uc009mlk.1 uc009mlk.2 uc009mlk.3 
ENSMUST00000005611.10 Myl10 ENSMUST00000005611.10 myosin, light chain 10, regulatory, transcript variant 1 (from RefSeq NM_021611.3) E9QNY3 E9QNY3_MOUSE ENSMUST00000005611.1 ENSMUST00000005611.2 ENSMUST00000005611.3 ENSMUST00000005611.4 ENSMUST00000005611.5 ENSMUST00000005611.6 ENSMUST00000005611.7 ENSMUST00000005611.8 ENSMUST00000005611.9 Myl10 NM_021611 uc009aau.1 uc009aau.2 uc009aau.3 calcium ion binding mitochondrion uc009aau.1 uc009aau.2 uc009aau.3 
ENSMUST00000005620.10 Dnajb1 ENSMUST00000005620.10 DnaJ heat shock protein family (Hsp40) member B1, transcript variant 1 (from RefSeq NM_018808.3) DNJB1_MOUSE ENSMUST00000005620.1 ENSMUST00000005620.2 ENSMUST00000005620.3 ENSMUST00000005620.4 ENSMUST00000005620.5 ENSMUST00000005620.6 ENSMUST00000005620.7 ENSMUST00000005620.8 ENSMUST00000005620.9 Hsp40 Hspf1 NM_018808 Q9QYJ3 uc009mkp.1 uc009mkp.2 uc009mkp.3 uc009mkp.4 uc009mkp.5 This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. The encoded protein may also inhibit apoptosis. Peritoneal macrophages derived from homozygous knockout mice for this gene exhibit impaired heat tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Interacts with DNAJC3. Interacts with HSF1 (via transactivation domain); this interaction results in the inhibition of heat shock- and HSF1-induced transcriptional activity during the attenuation and recovery phase period of the heat shock response. Cytoplasm Nucleus Nucleus, nucleolus Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock. By heat shock. ATPase activator activity transcription corepressor activity nucleus nucleolus cytoplasm cytosol protein folding postsynaptic density Hsp70 protein binding positive regulation of ATPase activity neuronal cell body dendritic spine protein binding involved in protein folding unfolded protein binding chaperone mediated protein folding requiring cofactor chaperone binding ATPase binding negative regulation of inclusion body assembly negative regulation of transcription from RNA polymerase II promoter in response to stress postsynapse glutamatergic synapse postsynaptic cytosol uc009mkp.1 uc009mkp.2 uc009mkp.3 uc009mkp.4 uc009mkp.5 
ENSMUST00000005630.11 Msh4 ENSMUST00000005630.11 mutS homolog 4, transcript variant 1 (from RefSeq NM_031870.4) ENSMUST00000005630.1 ENSMUST00000005630.10 ENSMUST00000005630.2 ENSMUST00000005630.3 ENSMUST00000005630.4 ENSMUST00000005630.5 ENSMUST00000005630.6 ENSMUST00000005630.7 ENSMUST00000005630.8 ENSMUST00000005630.9 MSH4_MOUSE NM_031870 Q920J1 Q99MT2 uc008rue.1 uc008rue.2 uc008rue.3 uc008rue.4 Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Heterooligomer of MSH4 and MSH5. Chromosome Predominantly expressed in testis. Belongs to the DNA mismatch repair MutS family. nucleotide binding nuclear chromosome resolution of meiotic recombination intermediates condensed chromosome condensed nuclear chromosome synaptonemal complex ovarian follicle development DNA binding ATP binding nucleus nucleoplasm recombination nodule mismatch repair synapsis reciprocal meiotic recombination spermatogenesis female gamete generation DNA-dependent ATPase activity mismatched DNA binding meiotic cell cycle uc008rue.1 uc008rue.2 uc008rue.3 uc008rue.4 
ENSMUST00000005647.4 Ndufs3 ENSMUST00000005647.4 NADH:ubiquinone oxidoreductase core subunit S3 (from RefSeq NM_026688.3) ENSMUST00000005647.1 ENSMUST00000005647.2 ENSMUST00000005647.3 NDUS3_MOUSE NM_026688 Q8BTZ3 Q8R073 Q9DCT2 uc008ktr.1 uc008ktr.2 uc008ktr.3 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:31916679, PubMed:33148885). Essential for the catalytic activity and assembly of complex I (PubMed:31916679, PubMed:33148885). Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence=; Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). Interacts with NDUFAF3 (By similarity). Interacts with RAB5IF (PubMed:31536960). Found in subcomplexes containing subunits NDUFS2, MT-ND1 and NDUFA13 (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Conditional knockout (KO) in the forebrain neurons results in reduced complex I activity, altered brain energy metabolism, increased locomotor activity with impaired motor coordination, balance and stereotyped behavior, neuroinflammation in cortex and hippocampus, and neuronal death in hippocampus (PubMed:33148885). Conditional KO in skeletal muscle results in development of a progressive myopathy resulting in premature death, muscle degeneration accompanied by increased mitochondrial proliferation and serum lactic acidosis and a decrease in complex I activity, assembly and expression in muscle (PubMed:31916679). Belongs to the complex I 30 kDa subunit family. NADH dehydrogenase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I NADH dehydrogenase (ubiquinone) activity membrane oxidoreductase activity nuclear body oxidoreductase activity, acting on NAD(P)H negative regulation of cell growth mitochondrial membrane myelin sheath oxidation-reduction process respiratory chain reactive oxygen species metabolic process negative regulation of intrinsic apoptotic signaling pathway uc008ktr.1 uc008ktr.2 uc008ktr.3 
ENSMUST00000005651.13 Por ENSMUST00000005651.13 cytochrome p450 oxidoreductase (from RefSeq NM_008898.2) ENSMUST00000005651.1 ENSMUST00000005651.10 ENSMUST00000005651.11 ENSMUST00000005651.12 ENSMUST00000005651.2 ENSMUST00000005651.3 ENSMUST00000005651.4 ENSMUST00000005651.5 ENSMUST00000005651.6 ENSMUST00000005651.7 ENSMUST00000005651.8 ENSMUST00000005651.9 NCPR_MOUSE NM_008898 P37040 Por uc008zyt.1 uc008zyt.2 uc008zyt.3 uc008zyt.4 This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Reaction=NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2 reduced [cytochrome P450]; Xref=Rhea:RHEA:24040, Rhea:RHEA- COMP:14627, Rhea:RHEA-COMP:14628, ChEBI:CHEBI:15378, ChEBI:CHEBI:55376, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60344; EC=1.6.2.4; Evidence= Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per monomer. ; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Note=Binds 1 FMN per monomer. ; Endoplasmic reticulum membrane ; Single-pass membrane protein ; Cytoplasmic side Belongs to the NADPH--cytochrome P450 reductase family. In the N-terminal section; belongs to the flavodoxin family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. regulation of growth plate cartilage chondrocyte proliferation NADPH-hemoprotein reductase activity cytochrome-b5 reductase activity, acting on NAD(P)H cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane cytosol response to nutrient nitric oxide dioxygenase activity electron carrier activity carnitine metabolic process response to hormone flavonoid metabolic process FMN binding membrane integral component of membrane oxidoreductase activity hydrolase activity internal peptidyl-lysine acetylation fatty acid oxidation enzyme binding electron transport chain positive regulation of chondrocyte differentiation positive regulation of monooxygenase activity response to drug negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process intracellular membrane-bounded organelle nitrate catabolic process positive regulation of cholesterol biosynthetic process positive regulation of smoothened signaling pathway nitric oxide catabolic process iron-cytochrome-c reductase activity flavin adenine dinucleotide binding NADP binding oxidation-reduction process negative regulation of lipase activity demethylation cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus cellular response to peptide hormone stimulus positive regulation of steroid hormone biosynthetic process regulation of cholesterol metabolic process cellular organofluorine metabolic process uc008zyt.1 uc008zyt.2 uc008zyt.3 uc008zyt.4 
ENSMUST00000005669.9 Cyp2b13 ENSMUST00000005669.9 cytochrome P450, family 2, subfamily b, polypeptide 13 (from RefSeq NM_007813.2) A6H6J2 A6H6J2_MOUSE Cyp2b13 E9Q713 ENSMUST00000005669.1 ENSMUST00000005669.2 ENSMUST00000005669.3 ENSMUST00000005669.4 ENSMUST00000005669.5 ENSMUST00000005669.6 ENSMUST00000005669.7 ENSMUST00000005669.8 NM_007813 uc009fug.1 uc009fug.2 uc009fug.3 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc009fug.1 uc009fug.2 uc009fug.3 
ENSMUST00000005671.10 Igf1r ENSMUST00000005671.10 insulin-like growth factor I receptor (from RefSeq NM_010513.3) E9QNX9 E9QNX9_MOUSE ENSMUST00000005671.1 ENSMUST00000005671.2 ENSMUST00000005671.3 ENSMUST00000005671.4 ENSMUST00000005671.5 ENSMUST00000005671.6 ENSMUST00000005671.7 ENSMUST00000005671.8 ENSMUST00000005671.9 Igf1r NM_010513 uc009hja.1 uc009hja.2 uc009hja.3 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence= Membrane ; Single- pass type I membrane protein Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity insulin-like growth factor-activated receptor activity insulin receptor binding insulin-like growth factor binding ATP binding protein phosphorylation immune response transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation membrane integral component of membrane kinase activity phosphorylation transferase activity positive regulation of cell migration insulin-like growth factor I binding alphav-beta3 integrin-IGF-1-IGF1R complex peptidyl-tyrosine autophosphorylation identical protein binding negative regulation of apoptotic process intracellular membrane-bounded organelle receptor complex phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding transcytosis regulation of JNK cascade protein autophosphorylation insulin-like growth factor receptor signaling pathway phosphatidylinositol-mediated signaling protein tetramerization inactivation of MAPKK activity beta-amyloid clearance cellular response to beta-amyloid uc009hja.1 uc009hja.2 uc009hja.3 
ENSMUST00000005678.6 Fcer2a ENSMUST00000005678.6 Fc receptor, IgE, low affinity II, alpha polypeptide, transcript variant 1 (from RefSeq NM_013517.4) ENSMUST00000005678.1 ENSMUST00000005678.2 ENSMUST00000005678.3 ENSMUST00000005678.4 ENSMUST00000005678.5 FCER2_MOUSE Fcer2 NM_013517 P20693 Q61556 Q61557 uc009ksn.1 uc009ksn.2 uc009ksn.3 Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway. Homotrimer. Interacts (via C-type lectin domain) with IGHE (via CH3 region); this interaction regulates IgE homeostasis. Interacts (via C-terminus) with CR2/CD21 (via Sushi domain 1 and 2). Cell membrane ; Single-pass type II membrane protein Cell membrane ; Lipid- anchor Secreted Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=P20693-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P20693-2; Sequence=VSP_003058; Name=3; Synonyms=C; IsoId=P20693-3; Sequence=VSP_003059; N- and O-glycosylated. There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes. Name=Functional Glycomics Gateway - Glycan Binding; Note=CD23; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_222"; positive regulation of humoral immune response mediated by circulating immunoglobulin plasma membrane external side of plasma membrane membrane integral component of membrane IgE binding carbohydrate binding metal ion binding positive regulation of nitric-oxide synthase activity positive regulation of killing of cells of other organism positive regulation of nitric-oxide synthase biosynthetic process uc009ksn.1 uc009ksn.2 uc009ksn.3 
ENSMUST00000005685.15 Cyp2a5 ENSMUST00000005685.15 cytochrome P450, family 2, subfamily a, polypeptide 5 (from RefSeq NM_007812.4) Cyp2a5 ENSMUST00000005685.1 ENSMUST00000005685.10 ENSMUST00000005685.11 ENSMUST00000005685.12 ENSMUST00000005685.13 ENSMUST00000005685.14 ENSMUST00000005685.2 ENSMUST00000005685.3 ENSMUST00000005685.4 ENSMUST00000005685.5 ENSMUST00000005685.6 ENSMUST00000005685.7 ENSMUST00000005685.8 ENSMUST00000005685.9 NM_007812 Q91X75 Q91X75_MOUSE uc009fuv.1 uc009fuv.2 uc009fuv.3 Cytochromes P450 are a group of heme-thiolate monooxygenases. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane Microsome membrane Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding metal ion binding oxidation-reduction process uc009fuv.1 uc009fuv.2 uc009fuv.3 
ENSMUST00000005692.14 Atp4a ENSMUST00000005692.14 ATPase, H+/K+ exchanging, gastric, alpha polypeptide, transcript variant 1 (from RefSeq NM_001290627.1) ATP4A_MOUSE Atp4a E9QNX7 ENSMUST00000005692.1 ENSMUST00000005692.10 ENSMUST00000005692.11 ENSMUST00000005692.12 ENSMUST00000005692.13 ENSMUST00000005692.2 ENSMUST00000005692.3 ENSMUST00000005692.4 ENSMUST00000005692.5 ENSMUST00000005692.6 ENSMUST00000005692.7 ENSMUST00000005692.8 ENSMUST00000005692.9 NM_001290627 Q64436 Q9CV46 uc057agw.1 uc057agw.2 uc057agw.3 The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells (PubMed:7762614). Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (PubMed:7762614). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (PubMed:10764766). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (PubMed:7762614) (By similarity). Reaction=ATP + H(+)(in) + H2O + K(+)(out) = ADP + 2 H(+)(out) + K(+)(in) + phosphate; Xref=Rhea:RHEA:22044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.19; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22045; Evidence=; The gastric H(+)/K(+) ATPase pump is composed of the catalytic alpha subunit ATP4A and the regulatory beta subunit ATP4B. Interacts (via the P-domain) with ATP4B (via N-terminus); this interaction stabilizes the lumenal-open E2 conformation state and prevents the reverse reaction of the transport cycle. Apical cell membrane ; Multi-pass membrane protein Note=Localized in the apical canalicular membrane of parietal cells (By similarity). Expressed in parietal cells (at protein level). Mutant mice are born at the expected Mendelian rate. They develop achlorhydria, hypergastrinemia and ciliated metaplasia. The parietal cell viability or chief cell differentiation are normal when compared to wild-type littermates. Mutant parietal cells have abnormal morphology characterized by dilated canaliculi with few microvilli, spherical vesicles rather than normal tubulovesicles and enlarged mitochondria filled with concentric cristae. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. nucleotide binding magnesium ion binding sodium:potassium-exchanging ATPase activity ATP binding plasma membrane ion transport potassium ion transport cellular sodium ion homeostasis potassium-transporting ATPase activity hydrogen:potassium-exchanging ATPase activity regulation of proton transport establishment or maintenance of transmembrane electrochemical gradient membrane integral component of membrane apical plasma membrane cellular potassium ion homeostasis sodium ion export from cell response to drug pH reduction metal ion binding protein heterodimerization activity hydrogen ion transmembrane transport potassium ion import across plasma membrane uc057agw.1 uc057agw.2 uc057agw.3 
ENSMUST00000005705.8 Trim28 ENSMUST00000005705.8 tripartite motif-containing 28 (from RefSeq NM_011588.3) ENSMUST00000005705.1 ENSMUST00000005705.2 ENSMUST00000005705.3 ENSMUST00000005705.4 ENSMUST00000005705.5 ENSMUST00000005705.6 ENSMUST00000005705.7 Kap1 Krip1 NM_011588 P70391 Q62318 Q8C283 Q99PN4 TIF1B_MOUSE Tif1b Trim28 uc009ffb.1 uc009ffb.2 uc009ffb.3 uc009ffb.4 Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs) (PubMed:20164836, PubMed:22110054, PubMed:25247314, PubMed:27658112). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:20164836). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA- methylation independent-pathway (PubMed:20164836). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity). Acts as a corepressor for ZFP568 (PubMed:22110054, PubMed:27658112). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein sumoylation. Oligomer; the RBCC domain homotrimerizes and interacts with one molecule of KRAB to form the KRAB-KAP1 corepressor complex. Interacts with SETX (By similarity). Binding to a KRAB domain is an absolute requirement for silencing gene expression. Interacts with a number of KRAB-ZFP proteins including ZNF10, ZFP53, ZFP68, ZNF382 and ZNF256. Interacts with NCOR1, NR3C1 and CHD3. Interacts with CEBPB (via the RING-type and PHD-type zinc fingers). Interacts with CBX5 (via the PxVxL motif); the interaction occurs in interphase nuclei and competes for binding POGZ (PubMed:10562550, PubMed:10330177, PubMed:25247314). Interacts with POGZ; the interaction competes for interaction with CBX5. Interacts with SETDB1; the interaction is enhanced by KAP1 sumoylation, stimulates SETDB1 histone methyltransferase activity and gene silencing. Interacts (via the PHD-type zinc finger) with UBE2I; the interaction is required for sumoylation and repressor activity. Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor and DNA damage responses. Interacts directly with ERBB4; the interaction represses ERBB4-mediated transcription activity. Interacts with MDM2; the interaction contributes to p53/TP53 inactivation. Component of the TRIM28/KAP1-MDM2-p53/TP53; involved in regulating p53/TP53 stabilization and activity. Interacts (via the leucine zipper alpha helical coiled-coil) with E2F1 (central region); the interaction inhibits E2F1 acetylation and transcriptional activity. Interacts with PPP1CA; the interaction dephosphorylates TRIM28 at Ser- 824 and forms a complex at the p21 promoter site. Interacts with PPP1CB; the interaction is weak but is increased on dephosphorylation at Ser-824. Interacts with CEBPB and NR3C1. Interacts with CBX5 (via the PxVxL motif); the interaction occurs in interphase nuclei and competes for binding POGZ. Component of a ternary complex that includes TRIM28, a HP1 protein (CBX1, CBX3 OR CBX5), a KRAB domain-containing protein, and DNA. Interacts with SMARCAD1. Interacts with, and sumoylates IRF7. Interacts with MAGEC2. Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Interacts (via the RBCC domain) with KOX1 (via the KRAB domain), ZNF268 (via the KRAB domain) and ZNF300 (via the KRAB domain); the interactions increase KOX1, ZNF268 and ZNF300 nuclear localization activities. Interacts with AICDA. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex. Interacts with NR4A3; the interactions potentiates NR4A3 activity on NurRE promoter (PubMed:19321449). Interacts (unphosphorylated or phosphorylated form) with ZBTB1 (via BTB domain) (By similarity). Probably part of a corepressor complex containing ZNF304, TRIM28, SETDB1 and DNMT1. Interacts with ATRX. Forms a complex with ATRX, SETDB1 and ZNF274 (By similarity). Interacts with ZFP568; the interaction mediates ZFP568 transcriptional repression activity (PubMed:22110054, PubMed:27658112). Interacts with RRP1B (By similarity). Interacts with CRY1 (PubMed:27123980). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (By similarity). Interacts with CYREN (via XLF motif) (PubMed:30017584). Interacts with TRIM17; this interaction prevents TRIM28 activity (By similarity). Interacts with ZNF746 (By similarity). Interacts with PHF13 (By similarity). Q62318; O35613: Daxx; NbExp=2; IntAct=EBI-346909, EBI-77304; Q62318; P12813: Nr4a1; NbExp=3; IntAct=EBI-346909, EBI-10896863; Q62318; P17918: Pcna; NbExp=2; IntAct=EBI-346909, EBI-1173716; Q62318-1; P45481: Crebbp; NbExp=2; IntAct=EBI-6876996, EBI-296306; Q62318-1; P20263: Pou5f1; NbExp=3; IntAct=EBI-6876996, EBI-1606219; Nucleus te=Associated with centromeric heterochromatin during cell differentiation through CBX1 (PubMed:10330177). Localizes to sites of DNA damage (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q62318-1; Sequence=Displayed; Name=2; IsoId=Q62318-2; Sequence=VSP_010899, VSP_010900; The HP1 box is both necessary and sufficient for HP1 binding. The PHD-type zinc finger enhances CEBPB transcriptional activity. The PHD-type zinc finger, the HP1 box and the bromo domain, function together to assemble the machinery required for repression of KRAB domain-containing proteins. Acts as an intramolecular SUMO E3 ligase for autosumoylation of bromodomain. The RING-finger-B Box-coiled-coil/tripartite motif (RBCC/TRIM motif) is required for interaction with the KRAB domain of KRAB-zinc finger proteins. Binds four zinc ions per molecule. The RING finger and the N-terminal of the leucine zipper alpha helical coiled-coil region of RBCC are required for oligomerization. Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain. ATM-induced phosphorylation on Ser-824 represses sumoylation leading to the de-repression of expression of a subset of genes involved in cell cycle control and apoptosis in response to genotoxic stress. Dephosphorylation by the phosphatases, PPP1CA and PP1CB forms, allows sumoylation and expression of TRIM28 target genes. Sumoylation/desumoylation events regulate TRIM28-mediated transcriptional repression. Sumoylation is required for interaction with CHD3 and SETDB1 and the corepressor activity. Represses and is repressed by Ser-824 phosphorylation. Enhances the TRIM28 corepressor activity, inhibiting transcriptional activity of a number of genes including GADD45A and CDKN1A/p21. Lys-554, Lys-779 and Lys-804 are the major sites of sumoylation. In response to Dox-induced DNA damage, enhanced phosphorylation on Ser-824 prevents sumoylation and allows de- repression of CDKN1A/p21. Auto-ubiquitinated; enhanced by MAGEA2 and MAGEC2. Citrullinated by PADI4. ADP-ribosylated by SIRT6, promoting TRIM28/KAP1 interaction with CBX5, thereby contributing to the packaging of LINE-1 retrotransposon elements into transcriptionally repressive heterochromatin. Embryonic lethal with arrest at stage E5.5. Gastrulation fails and expression of the critical mesoderm differentiation factor T/brachyury is lost. Belongs to the TRIM/RBCC family. negative regulation of transcription from RNA polymerase II promoter chromatin in utero embryonic development epithelial to mesenchymal transition DNA binding chromatin binding transcription coactivator activity transcription corepressor activity protein kinase activity ubiquitin-protein transferase activity protein binding nucleus nucleoplasm nuclear euchromatin nuclear heterochromatin DNA repair chromatin organization protein phosphorylation Ras protein signal transduction embryo implantation zinc ion binding protein ubiquitination transferase activity protein sumoylation SUMO transferase activity ubiquitin protein ligase binding Krueppel-associated box domain binding positive regulation of protein import into nucleus DNA methylation involved in embryo development positive regulation of DNA binding innate immune response positive regulation of DNA repair negative regulation of single stranded viral RNA replication via double stranded DNA intermediate negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated protein autophosphorylation metal ion binding protein oligomerization convergent extension involved in axis elongation embryonic placenta morphogenesis chromo shadow domain binding positive regulation of methylation-dependent chromatin silencing RNA polymerase II transcription factor complex negative regulation of DNA demethylation negative regulation of viral release from host cell promoter-specific chromatin binding regulation of genetic imprinting sequence-specific DNA binding nucleolus uc009ffb.1 uc009ffb.2 uc009ffb.3 uc009ffb.4 
ENSMUST00000005711.6 Chmp2a ENSMUST00000005711.6 charged multivesicular body protein 2A, transcript variant 2 (from RefSeq NM_026885.3) CHM2A_MOUSE ENSMUST00000005711.1 ENSMUST00000005711.2 ENSMUST00000005711.3 ENSMUST00000005711.4 ENSMUST00000005711.5 NM_026885 Q9DB34 uc009ffc.1 uc009ffc.2 uc009ffc.3 uc009ffc.4 Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (By similarity). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. In vitro, heteromerizes with CHMP3 (but not CHMP4) to form helical tubular structures that expose membrane- interacting sites on the outside whereas VPS4B can associate on the inside of the tubule. Interacts with CHMP1B, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP5. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with MITD1. Interacts with VTA1; the interaction probably involves the open conformation of CHMP2A (By similarity). Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm Nucleus envelope Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body. Localizes to the reforming nuclear envelope on chromatin disks during late anaphase (By similarity). Widely expressed. Highly expressed in brain, heart, liver and kidney. The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components. ISGylated in a CHMP5-dependent manner. Isgylation weakens and inhibits its interactions with VPS4A and VTA1 respectively (By similarity). Belongs to the SNF7 family. chromatin ESCRT III complex protein binding nuclear envelope cytoplasm endosome multivesicular body cytosol nucleus organization vacuolar transport mitotic metaphase plate congression membrane invagination exit from mitosis regulation of centrosome duplication protein transport membrane protein domain specific binding membrane coat phosphatidylcholine binding nuclear envelope reassembly late endosome membrane endosome transport via multivesicular body sorting pathway viral budding via host ESCRT complex establishment of protein localization late endosome to vacuole transport regulation of viral process protein polymerization protein homooligomerization protein heterooligomerization negative regulation of cell death regulation of mitotic spindle assembly positive regulation of viral release from host cell positive regulation of exosomal secretion negative regulation of centriole elongation uc009ffc.1 uc009ffc.2 uc009ffc.3 uc009ffc.4 
ENSMUST00000005714.14 Ube2m ENSMUST00000005714.14 ubiquitin-conjugating enzyme E2M, transcript variant 1 (from RefSeq NM_145578.3) ENSMUST00000005714.1 ENSMUST00000005714.10 ENSMUST00000005714.11 ENSMUST00000005714.12 ENSMUST00000005714.13 ENSMUST00000005714.2 ENSMUST00000005714.3 ENSMUST00000005714.4 ENSMUST00000005714.5 ENSMUST00000005714.6 ENSMUST00000005714.7 ENSMUST00000005714.8 ENSMUST00000005714.9 NM_145578 O76069 P61082 Q8VC50 UBC12_MOUSE Ubc-rs2 Ubc12 uc009ffd.1 uc009ffd.2 uc009ffd.3 uc009ffd.4 Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. Reaction=[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]- yl-L-cysteine.; EC=2.3.2.34; Evidence=; Protein modification; protein neddylation. Interacts with UBA3 and RBX1. Interacts (N-terminally acetylated form) with (via DCUN1 domain) DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5. Both the N-terminal docking peptide and the catalytic core domain must bind the UBA3-NAE1 complex simultaneously for optimal transfer of NEDD8. The acetylation of Met-1 increases affinity for DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins. Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily. nucleotide binding ubiquitin-protein transferase activity ATP binding cellular protein modification process protein ubiquitination transferase activity NEDD8 transferase activity positive regulation of neuron apoptotic process protein neddylation uc009ffd.1 uc009ffd.2 uc009ffd.3 uc009ffd.4 
ENSMUST00000005749.6 Ctr9 ENSMUST00000005749.6 CTR9 homolog, Paf1/RNA polymerase II complex component (from RefSeq NM_009431.2) CTR9_MOUSE ENSMUST00000005749.1 ENSMUST00000005749.2 ENSMUST00000005749.3 ENSMUST00000005749.4 ENSMUST00000005749.5 Kiaa0155 NM_009431 Q3UFF5 Q3UY40 Q62018 Q66JX4 Q7TPS6 Q8BND9 Q8BRD1 Q8C9W7 Q8C9Y3 Q8CHI1 Sh2bp1 uc009jfx.1 uc009jfx.2 Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription (By similarity). Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3. Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and SKIC8 (By similarity). The PAF1 complex interacts with PHF5A (PubMed:27749823). Interacts with KMT2A/MLL1 (By similarity). Interacts with STAT3 (PubMed:17911113). Interacts with SETD5 (PubMed:27864380). Interacts with ERCC6 (By similarity). Nucleus speckle Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q62018-1; Sequence=Displayed; Name=2; IsoId=Q62018-2; Sequence=VSP_017846, VSP_017847; Name=3; IsoId=Q62018-3; Sequence=VSP_017848, VSP_017849; Widely expressed. Sequence=AAH53910.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 937.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core binding endodermal cell fate commitment inner cell mass cell differentiation trophectodermal cell differentiation blastocyst growth blastocyst hatching protein binding nucleus nucleoplasm regulation of transcription, DNA-templated JAK-STAT cascade histone monoubiquitination Wnt signaling pathway histone modification Cdc73/Paf1 complex nuclear speck stem cell population maintenance positive regulation of transcription elongation from RNA polymerase II promoter histone H2B ubiquitination transcriptionally active chromatin SH2 domain binding negative regulation of myeloid cell differentiation positive regulation of transcription from RNA polymerase II promoter regulation of histone H3-K4 methylation positive regulation of histone H3-K4 methylation interleukin-6-mediated signaling pathway cellular response to lipopolysaccharide histone H3-K4 trimethylation negative regulation of mRNA polyadenylation regulation of genetic imprinting positive regulation of histone H3-K79 methylation positive regulation of histone H2B ubiquitination uc009jfx.1 uc009jfx.2 
ENSMUST00000005751.13 Irag1 ENSMUST00000005751.13 inositol 1,4,5-triphosphate receptor associated 1 (from RefSeq NM_194464.3) ENSMUST00000005751.1 ENSMUST00000005751.10 ENSMUST00000005751.11 ENSMUST00000005751.12 ENSMUST00000005751.2 ENSMUST00000005751.3 ENSMUST00000005751.4 ENSMUST00000005751.5 ENSMUST00000005751.6 ENSMUST00000005751.7 ENSMUST00000005751.8 ENSMUST00000005751.9 IRAG1_MOUSE Irag Mrvi1 NM_194464 Q3U069 Q9R2C5 Q9WUX5 uc009jfu.1 uc009jfu.2 uc009jfu.3 uc009jfu.4 uc009jfu.5 This gene is a putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein participates in signaling by nitric oxide (NO) to inhibit intracellular calcium release and platelet aggregation in cardiovascular tissue. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]. Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO- dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with PRKG1/cGKI-beta and ITPR1/IP3R type I. Membrane ; Single-pass membrane protein Cytoplasm, perinuclear region Sarcoplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=IRAG1a; IsoId=Q9WUX5-1; Sequence=Displayed; Name=2; IsoId=Q9WUX5-2; Sequence=VSP_028343; Highly expressed in smooth muscle such as aorta, colon and uterus. Detected in the brain, in the thalamus, in the hippocampus and myenteric plexus. Highly expressed in megakaryocytes. Down-regulated during macrophage differentiation. Phosphorylated by PRKG1/cGKI. Mice lacking coiled-coil region N-terminal part exhibit disruption of IRAG1-ITPR1 interaction. They have dilated gastrointestinal tract and disturbed gastrointestinal motility. Smooth muscle are no more relaxed by cGMP after phenilephrine-induced contraction and half of the homozygous mice dies before the age of 6 months. Nitric oxide (NO) and cGMP-mediated inhibition of collagen- induced platelet aggregation is strongly suppressed in platelets of these transgenic mice. growth. IRAG1 gene is a common integration site of murine leukemia virus, leading to induce myeloid leukemia in BXH2 mice. Murine leukemia virus integration occurs at the 5' end of the gene between 2 differentially used promoters and thus probably alters the expression of an important gene for myeloid cell growth. Sequence=AAD22569.1; Type=Frameshift; Evidence=; protein binding cytoplasm membrane integral component of membrane sarcoplasmic reticulum cGMP-mediated signaling negative regulation of smooth muscle contraction perinuclear region of cytoplasm relaxation of vascular smooth muscle uc009jfu.1 uc009jfu.2 uc009jfu.3 uc009jfu.4 uc009jfu.5 
ENSMUST00000005769.13 Tmod4 ENSMUST00000005769.13 tropomodulin 4 (from RefSeq NM_016712.4) ENSMUST00000005769.1 ENSMUST00000005769.10 ENSMUST00000005769.11 ENSMUST00000005769.12 ENSMUST00000005769.2 ENSMUST00000005769.3 ENSMUST00000005769.4 ENSMUST00000005769.5 ENSMUST00000005769.6 ENSMUST00000005769.7 ENSMUST00000005769.8 ENSMUST00000005769.9 NM_016712 Q9JLH8 TMOD4_MOUSE uc008qib.1 uc008qib.2 uc008qib.3 Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). Binds to the N-terminus of tropomyosin and to actin. Cytoplasm, cytoskeleton Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments. Belongs to the tropomodulin family. actin binding tropomyosin binding cytoplasm cytoskeleton striated muscle thin filament muscle contraction myofibril myofibril assembly actin filament binding pointed-end actin filament capping uc008qib.1 uc008qib.2 uc008qib.3 
ENSMUST00000005791.14 Cabp5 ENSMUST00000005791.14 calcium binding protein 5, transcript variant 10 (from RefSeq NR_184751.1) CABP5_MOUSE ENSMUST00000005791.1 ENSMUST00000005791.10 ENSMUST00000005791.11 ENSMUST00000005791.12 ENSMUST00000005791.13 ENSMUST00000005791.2 ENSMUST00000005791.3 ENSMUST00000005791.4 ENSMUST00000005791.5 ENSMUST00000005791.6 ENSMUST00000005791.7 ENSMUST00000005791.8 ENSMUST00000005791.9 NR_184751 Q9JLK3 uc009ffv.1 uc009ffv.2 uc009ffv.3 Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials (PubMed:18586882). Involved in the transmission of light signals (PubMed:18586882). May positively regulate neurotransmitter vesicle endocytosis and exocytosis in a salt-dependent manner (PubMed:22039235). May play a role in the extension and network organization of neurites (PubMed:22039235). Interacts with CACNA1C (via C-terminal CDB motif) in a calcium-dependent manner (PubMed:18586882). Interacts with STXBP1 (By similarity). Interacts with MYO6 (By similarity). Cytoplasm Expressed in inner and outer plexiform layers of the retina, and retinal bipolar cells (at protein level) (PubMed:17947313, PubMed:18586882, PubMed:22039235). Expressed in the inner hair cells (IHC) of the cochlea (PubMed:17947313, PubMed:18586882). No morphologic changes, but 50% reduction of the sensitivity of retinal ganglion cell light responses. calcium ion binding cytoplasm cytosol metal ion binding uc009ffv.1 uc009ffv.2 uc009ffv.3 
ENSMUST00000005798.9 Snx6 ENSMUST00000005798.9 sorting nexin 6, transcript variant 1 (from RefSeq NM_026998.4) ENSMUST00000005798.1 ENSMUST00000005798.2 ENSMUST00000005798.3 ENSMUST00000005798.4 ENSMUST00000005798.5 ENSMUST00000005798.6 ENSMUST00000005798.7 ENSMUST00000005798.8 NM_026998 Q6P8X1 Q9CZ03 SNX6_MOUSE uc007nnv.1 uc007nnv.2 uc007nnv.3 Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome- to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity (By similarity). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation (By similarity). In association with GIT1 involved in EGFR degradation (PubMed:18523162). Promotes lysosomal degradation of CDKN1B (PubMed:20228253). May contribute to transcription regulation (By similarity). Forms heterodimers with BAR domain-containing sorting nexins SNX1 and SNX2. The heterodimers are proposed to self-assemble into helical arrays on the membrane to stabilize and expand local membrane curvature underlying endosomal tubule formation. Thought to be a component of the originally described retromer complex (also called SNX-BAR retromer) which is a pentamer containing the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), and a heterodimeric membrane- deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity (By similarity). Interacts with SNX1, SNX2, VPS26A, VPS29, VPS35, TGFB receptors, BACE1, BRMS1, PIP5K1C. Interacts with DCTN1; the association with DCTN1 is involved in movement of retromer-c ontaining vesicles toward the TGN. Interacts with PIM1; translocating SNX6 to the nucleus (By similarity). Interacts with CDKN1B and GIT1 (PubMed:18523162, PubMed:20228253). Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle Cytoplasm Nucleus Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (By similarity). Only a minor proportion is seen in the nucleus (By similarity). The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5- bisphosphate. The BAR domain is able to sense membrane curvature upon dimerization. Membrane remodeling seems to implicate insertion of an amphipathic helix (AH) in the membrane (By similarity). In vitro phosphorylated by PIM1; not affecting PIM1-dependent nuclear translocation (By similarity). Belongs to the sorting nexin family. nucleus cytoplasm endosome cytosol intracellular protein transport lipid binding protein transport membrane negative regulation of transforming growth factor beta receptor signaling pathway retromer complex cytoplasmic vesicle early endosome membrane dynactin binding type I transforming growth factor beta receptor binding phosphatidylinositol binding retrograde transport, endosome to Golgi protein homodimerization activity negative regulation of neuron apoptotic process negative regulation of transcription, DNA-templated cellular response to epidermal growth factor stimulus tubular endosome cellular response to beta-amyloid uc007nnv.1 uc007nnv.2 uc007nnv.3 
ENSMUST00000005810.9 Mthfd2 ENSMUST00000005810.9 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase (from RefSeq NM_008638.2) ENSMUST00000005810.1 ENSMUST00000005810.2 ENSMUST00000005810.3 ENSMUST00000005810.4 ENSMUST00000005810.5 ENSMUST00000005810.6 ENSMUST00000005810.7 ENSMUST00000005810.8 MTDC_MOUSE NM_008638 Nmdmc P18155 Q3TMN4 uc009cne.1 uc009cne.2 uc009cne.3 uc009cne.4 Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)- 5,10-methenyltetrahydrofolate + NADH; Xref=Rhea:RHEA:22892, ChEBI:CHEBI:15636, ChEBI:CHEBI:57455, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.5.1.15; Evidence= Reaction=(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10- formyltetrahydrofolate + H(+); Xref=Rhea:RHEA:23700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57455, ChEBI:CHEBI:195366; EC=3.5.4.9; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Homodimer. Mitochondrion. This NAD-dependent bifunctional enzyme has very different kinetic properties than the larger NADP-dependent trifunctional enzyme and is unique in that it requires formation of an enzyme-magnesium complex to allow binding of NAD. Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. magnesium ion binding catalytic activity methenyltetrahydrofolate cyclohydrolase activity methylenetetrahydrofolate dehydrogenase (NAD+) activity methylenetetrahydrofolate dehydrogenase (NADP+) activity mitochondrion one-carbon metabolic process metabolic process oxidoreductase activity hydrolase activity tetrahydrofolate interconversion phosphate ion binding tetrahydrofolate metabolic process oxidation-reduction process uc009cne.1 uc009cne.2 uc009cne.3 uc009cne.4 
ENSMUST00000005815.7 Kit ENSMUST00000005815.7 KIT proto-oncogene receptor tyrosine kinase, transcript variant 1 (from RefSeq NM_001122733.1) ENSMUST00000005815.1 ENSMUST00000005815.2 ENSMUST00000005815.3 ENSMUST00000005815.4 ENSMUST00000005815.5 ENSMUST00000005815.6 KIT_MOUSE NM_001122733 P05532 Q61415 Q61416 Q61417 Q6LEE9 Q6QJB7 Q6QJB8 Q7TS86 Q8C8K9 Sl uc008xug.1 uc008xug.2 uc008xug.3 uc008xug.4 uc008xug.5 The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence= Present in an inactive conformation in the absence of bound ligand. KITLG/SCF binding leads to dimerization and activation by autophosphorylation. Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with DOK1 and TEC (By similarity). Interacts with the protein kinase FES/FPS. Interacts with PLCG1. Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3 catalytic subunit. Interacts (KITLG/SCF-bound) with IL1RL1. Interacts with IL1RAP (independent of stimulation with KITLG/SCF). A mast cell- specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88. P05532; P26955: Csf2rb; NbExp=4; IntAct=EBI-8559255, EBI-1810026; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. [Isoform 2]: Cell membrane; Single-pass type I membrane protein. [Isoform 3]: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=GNNK(+), KitA(+); IsoId=P05532-1; Sequence=Displayed; Name=2; Synonyms=GNNK(-), Kit(+); IsoId=P05532-2; Sequence=VSP_041870; Name=3; Synonyms=Tr-kit, Truncated; IsoId=P05532-3; Sequence=VSP_041868, VSP_041869; Isoform 1 and isoform 2 are detected in bone marrow cells, spermatogonia and spermatocytes, but not in round spermatids, elongating spermatids and spermatozoa. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa, but not in spermatogonia and spermatocytes (at protein level). Isoform 1 is widely expressed and detected in fetal liver and bone marrow. Isoform 3 is detected in bone marrow cells enriched in hematopoietic stem cells. Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation (By similarity). Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation of isoform 1 and isoform 2. Isoform 1 shows low levels of tyrosine phosphorylation in the absence of added KITLG/SCF, while isoform 2 requires stimulation by KITLG/SCF for phosphorylation (in vitro). Phosphorylation of Tyr-573 is required for interaction with PTPN6/SHP-1. Phosphorylation of Tyr-571 is required for interaction with PTPN11/SHP-2. Phosphorylated tyrosine residues are important for interaction with specific binding partners. Note=Defects in Kit are the cause of the white-spotting phenotype (W). White-spotting variants induces severe effects on pigmentation, gametogenesis and hematopoiesis. Mice homozygous for W42 die perinatally of macrocytic anemia. Numerous proteins are phosphorylated in response to KIT signaling, but it is not evident to determine which are directly phosphorylated by KIT under in vivo conditions. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. nucleotide binding activation of MAPK activity ovarian follicle development acrosomal vesicle protease binding hematopoietic progenitor cell differentiation myeloid progenitor cell differentiation lymphoid progenitor cell differentiation immature B cell differentiation dendritic cell cytokine production mast cell chemotaxis myeloid leukocyte differentiation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity stem cell factor receptor activity protein binding ATP binding extracellular space cytoplasm plasma membrane integral component of plasma membrane cell-cell junction protein phosphorylation glycosphingolipid metabolic process chemotaxis inflammatory response transmembrane receptor protein tyrosine kinase signaling pathway germ cell development spermatogenesis spermatid development positive regulation of cell proliferation germ cell migration regulation of cell shape visual learning male gonad development response to radiation external side of plasma membrane cytoplasmic side of plasma membrane cell surface positive regulation of gene expression membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cytokine binding lamellipodium assembly hemopoiesis cell differentiation B cell differentiation T cell differentiation erythrocyte differentiation melanocyte differentiation positive regulation of cell migration positive regulation of pseudopodium assembly actin cytoskeleton reorganization mast cell cytokine production somatic stem cell population maintenance embryonic hemopoiesis ectopic germ cell programmed cell death intracellular signal transduction hematopoietic stem cell migration megakaryocyte development Fc receptor signaling pathway Kit signaling pathway erythropoietin-mediated signaling pathway SH2 domain binding positive regulation of tyrosine phosphorylation of STAT protein mast cell granule protein homodimerization activity negative regulation of programmed cell death receptor complex mast cell degranulation positive regulation of MAP kinase activity positive regulation of MAPK cascade pigmentation tongue development positive regulation of Notch signaling pathway positive regulation of JAK-STAT cascade response to cadmium ion protein autophosphorylation metal ion binding developmental pigmentation somatic stem cell division positive regulation of long-term neuronal synaptic plasticity digestive tract development stem cell differentiation epithelial cell proliferation detection of mechanical stimulus involved in sensory perception of sound positive regulation of sequence-specific DNA binding transcription factor activity cell chemotaxis mast cell differentiation cellular response to thyroid hormone stimulus melanocyte migration melanocyte adhesion regulation of bile acid metabolic process positive regulation of colon smooth muscle contraction positive regulation of small intestine smooth muscle contraction positive regulation of vascular smooth muscle cell differentiation uc008xug.1 uc008xug.2 uc008xug.3 uc008xug.4 uc008xug.5 
ENSMUST00000005817.9 Tomm40l ENSMUST00000005817.9 translocase of outer mitochondrial membrane 40-like, transcript variant 2 (from RefSeq NM_001412746.1) ENSMUST00000005817.1 ENSMUST00000005817.2 ENSMUST00000005817.3 ENSMUST00000005817.4 ENSMUST00000005817.5 ENSMUST00000005817.6 ENSMUST00000005817.7 ENSMUST00000005817.8 NM_001412746 Q9CZR3 TM40L_MOUSE Tomm40b uc057avx.1 uc057avx.2 uc057avx.3 Potential channel-forming protein implicated in import of protein precursors into mitochondria. Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L and TOMM70. Interacts with mitochondrial targeting sequences (By similarity). Mitochondrion outer membrane ; Multi-pass membrane protein Belongs to the Tom40 family. mitochondrion mitochondrial outer membrane mitochondrial outer membrane translocase complex ion transport protein transmembrane transporter activity protein transport porin activity membrane integral component of membrane protein import into mitochondrial matrix mitochondrion targeting sequence binding macromolecular complex pore complex transmembrane transport preprotein binding uc057avx.1 uc057avx.2 uc057avx.3 
ENSMUST00000005820.11 Nr1i3 ENSMUST00000005820.11 nuclear receptor subfamily 1, group I, member 3, transcript variant 1 (from RefSeq NM_009803.5) Car ENSMUST00000005820.1 ENSMUST00000005820.10 ENSMUST00000005820.2 ENSMUST00000005820.3 ENSMUST00000005820.4 ENSMUST00000005820.5 ENSMUST00000005820.6 ENSMUST00000005820.7 ENSMUST00000005820.8 ENSMUST00000005820.9 NM_009803 NR1I3_MOUSE O35627 O35628 Q3V008 uc007dnf.1 uc007dnf.2 uc007dnf.3 Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity). Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Interacts with ECT2. Directly interacts with DNAJC7; this complex may also include HSP90. Interacts with CRY1 (PubMed:28751364). Interacts with CRY2 in a ligand-dependent manner (PubMed:28751364). Nucleus. Cytoplasm. Cytoplasm, cytoskeleton Note=Recruited to the cytoplasm by DNAJC7. Event=Alternative splicing; Named isoforms=2; Name=CAR1; IsoId=O35627-1; Sequence=Displayed; Name=CAR2; IsoId=O35627-2; Sequence=VSP_003671, VSP_003672; Predominantly expressed in liver. Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains. Phosphorylated at Thr-48 by PKC, dephosphorylation of Thr-48 is required for nuclear translocation and activation. [Isoform CAR2]: Does not seem to act as a transactivator. Lacks the C-terminal portion of the ligand binding/dimerization domain. Belongs to the nuclear hormone receptor family. NR1 subfamily. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol cytoskeleton regulation of transcription, DNA-templated lipid metabolic process multicellular organism development transcription factor binding zinc ion binding cell differentiation ligand-dependent nuclear receptor transcription coactivator activity intracellular receptor signaling pathway signaling receptor activity cholesterol homeostasis steroid hormone mediated signaling pathway sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding lipid homeostasis cellular response to lipopolysaccharide RNA polymerase II transcription factor complex uc007dnf.1 uc007dnf.2 uc007dnf.3 
ENSMUST00000005826.9 Cs ENSMUST00000005826.9 citrate synthase (from RefSeq NM_026444.4) CISY_MOUSE ENSMUST00000005826.1 ENSMUST00000005826.2 ENSMUST00000005826.3 ENSMUST00000005826.4 ENSMUST00000005826.5 ENSMUST00000005826.6 ENSMUST00000005826.7 ENSMUST00000005826.8 NM_026444 Q3UDP3 Q9CZU6 uc007hmj.1 uc007hmj.2 uc007hmj.3 The protein encoded by this gene is a central metabolic pathway enzyme, catalyzing the first step of the tricarboxylic acid cycle in which acetyl coenzyme A and oxaloacetate are converted to citrate and coenzyme A. This enzyme is found in nearly all cells capable of oxidative metabolism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149990.1, SRR1660817.294434.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+); Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.3.1; Evidence= Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2. Homodimer. Mitochondrion matrix Methylated. Trimethylation at Lys-395 by CSKMT decreases citrate synthase activity. Citrate synthase is found in nearly all cells capable of oxidative metabolism. Belongs to the citrate synthase family. citrate (Si)-synthase activity mitochondrion mitochondrial matrix carbohydrate metabolic process acetyl-CoA metabolic process tricarboxylic acid cycle citrate metabolic process oxaloacetate metabolic process transferase activity transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer uc007hmj.1 uc007hmj.2 uc007hmj.3 
ENSMUST00000005830.15 Bcas2 ENSMUST00000005830.15 BCAS2 pre-mRNA processing factor, transcript variant 1 (from RefSeq NM_026602.4) Dam1 ENSMUST00000005830.1 ENSMUST00000005830.10 ENSMUST00000005830.11 ENSMUST00000005830.12 ENSMUST00000005830.13 ENSMUST00000005830.14 ENSMUST00000005830.2 ENSMUST00000005830.3 ENSMUST00000005830.4 ENSMUST00000005830.5 ENSMUST00000005830.6 ENSMUST00000005830.7 ENSMUST00000005830.8 ENSMUST00000005830.9 NM_026602 Q3TKJ5 Q91YX8 Q9D287 Q9D2U4 Q9DAI0 SPF27_MOUSE uc008qsu.1 uc008qsu.2 uc008qsu.3 uc008qsu.4 Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19- CDC5L complex may also play a role in the response to DNA damage (DDR). Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly in the complex with PRPF19, CDC5L and PLRG1. Nucleus Nucleus, nucleolus Belongs to the SPF27 family. mRNA splicing, via spliceosome Prp19 complex molecular_function nucleus DNA replication factor A complex spliceosomal complex nucleolus centrosome mRNA processing RNA splicing nuclear speck U2-type catalytic step 2 spliceosome uc008qsu.1 uc008qsu.2 uc008qsu.3 uc008qsu.4 
ENSMUST00000005841.16 Ctcf ENSMUST00000005841.16 CCCTC-binding factor, transcript variant 1 (from RefSeq NM_181322.4) CTCF_MOUSE ENSMUST00000005841.1 ENSMUST00000005841.10 ENSMUST00000005841.11 ENSMUST00000005841.12 ENSMUST00000005841.13 ENSMUST00000005841.14 ENSMUST00000005841.15 ENSMUST00000005841.2 ENSMUST00000005841.3 ENSMUST00000005841.4 ENSMUST00000005841.5 ENSMUST00000005841.6 ENSMUST00000005841.7 ENSMUST00000005841.8 ENSMUST00000005841.9 NM_181322 Q61164 uc009ndm.1 uc009ndm.2 uc009ndm.3 uc009ndm.4 Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as a transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays an important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (By similarity). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Regulates asynchronous replication of IGF2/H19. Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (By similarity). Interacts with CHD8 (PubMed:16949368). Interacts with LLPH (PubMed:26961175). Interacts with CENPE (By similarity). Q61164; Q09XV5: Chd8; NbExp=3; IntAct=EBI-932785, EBI-1169080; Nucleus, nucleoplasm Chromosome Chromosome, centromere Note=May translocate to the nucleolus upon cell differentiation. Associates with both centromeres and chromosomal arms during metaphase. Associates with the H19 ICR in mitotic chromosomes. May be preferentially excluded from heterochromatin during interphase. Sumoylated on Lys-74 and Lys-698; sumoylation of CTCF contributes to the repressive function of CTCF on the MYC P2 promoter. Belongs to the CTCF zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter chromosome, centromeric region condensed chromosome RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm chromosome nucleolus DNA methylation chromatin organization regulation of gene expression by genetic imprinting regulation of transcription, DNA-templated chromosome segregation negative regulation of cell proliferation dosage compensation by inactivation of X chromosome maintenance of DNA methylation positive regulation of gene expression negative regulation of gene expression nucleosome positioning regulation of histone methylation regulation of histone acetylation regulation of gene expression, epigenetic regulation of molecular function, epigenetic chromatin insulator sequence binding sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated metal ion binding protein localization to chromosome, centromeric region positive regulation of pri-miRNA transcription from RNA polymerase II promoter uc009ndm.1 uc009ndm.2 uc009ndm.3 uc009ndm.4 
ENSMUST00000005862.9 Tfap4 ENSMUST00000005862.9 transcription factor AP4, transcript variant 1 (from RefSeq NM_031182.3) Ap4 ENSMUST00000005862.1 ENSMUST00000005862.2 ENSMUST00000005862.3 ENSMUST00000005862.4 ENSMUST00000005862.5 ENSMUST00000005862.6 ENSMUST00000005862.7 ENSMUST00000005862.8 NM_031182 Q9JIZ5 Q9JIZ5_MOUSE Tcfap4 Tfap4 uc007xzv.1 uc007xzv.2 uc007xzv.3 Q9JIZ5; O88513: Gmnn; NbExp=2; IntAct=EBI-15597718, EBI-445922; Q9JIZ5; Q03347: Runx1; NbExp=2; IntAct=EBI-15597718, EBI-3863873; RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus mitochondrion regulation of transcription from RNA polymerase II promoter DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator negative regulation of cell proliferation negative regulation of gene expression transcriptional repressor complex protein homodimerization activity histone deacetylase binding positive regulation of apoptotic process negative regulation of DNA binding sequence-specific DNA binding negative regulation by host of viral transcription positive regulation by host of viral transcription transcription regulatory region DNA binding mitotic cell cycle phase transition negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity macromolecular complex assembly E-box binding negative regulation of cell cycle arrest cellular response to dexamethasone stimulus regulation of mitotic cell cycle phase transition positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway uc007xzv.1 uc007xzv.2 uc007xzv.3 
ENSMUST00000005889.16 Vav1 ENSMUST00000005889.16 vav 1 oncogene, transcript variant 1 (from RefSeq NM_011691.4) ENSMUST00000005889.1 ENSMUST00000005889.10 ENSMUST00000005889.11 ENSMUST00000005889.12 ENSMUST00000005889.13 ENSMUST00000005889.14 ENSMUST00000005889.15 ENSMUST00000005889.2 ENSMUST00000005889.3 ENSMUST00000005889.4 ENSMUST00000005889.5 ENSMUST00000005889.6 ENSMUST00000005889.7 ENSMUST00000005889.8 ENSMUST00000005889.9 NM_011691 Q3U9E2 Q3U9E2_MOUSE Vav Vav1 uc008dep.1 uc008dep.2 uc008dep.3 uc008dep.4 phosphotyrosine binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity small GTPase mediated signal transduction regulation of cell size regulation of Rho protein signal transduction intracellular signal transduction regulation of GTPase activity metal ion binding uc008dep.1 uc008dep.2 uc008dep.3 uc008dep.4 
ENSMUST00000005891.7 Klk9 ENSMUST00000005891.7 kallikrein related-peptidase 9 (from RefSeq NM_028660.3) ENSMUST00000005891.1 ENSMUST00000005891.2 ENSMUST00000005891.3 ENSMUST00000005891.4 ENSMUST00000005891.5 ENSMUST00000005891.6 Klk9 Klnf NM_028660 Q32M27 Q32M27_MOUSE uc009gnr.1 uc009gnr.2 uc009gnr.3 uc009gnr.4 molecular_function serine-type endopeptidase activity proteolysis biological_process peptidase activity serine-type peptidase activity hydrolase activity secretory granule uc009gnr.1 uc009gnr.2 uc009gnr.3 uc009gnr.4 
ENSMUST00000005907.12 Cd247 ENSMUST00000005907.12 CD247 antigen, transcript variant zeta (from RefSeq NM_001113391.2) CD3Z_MOUSE Cd3z ENSMUST00000005907.1 ENSMUST00000005907.10 ENSMUST00000005907.11 ENSMUST00000005907.2 ENSMUST00000005907.3 ENSMUST00000005907.4 ENSMUST00000005907.5 ENSMUST00000005907.6 ENSMUST00000005907.7 ENSMUST00000005907.8 ENSMUST00000005907.9 NM_001113391 P24161 P29020 Q9D3G3 Tcrz uc007djn.1 uc007djn.2 uc007djn.3 uc007djn.4 Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN). The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with SLA (PubMed:10662792). Interacts with SLA2 (PubMed:11891219). Interacts with TRAT1. Interacts with DOCK2. Interacts with SHB. Interacts with ZAP70. Interacts (tyrosine phosphorylated) with SHC1 (via SH2 domain). Interacts with PTPRC (By similarity). Interacts with CRK; this interaction regulates CD3Z phosphorylation (By similarity). Interacts (on T cell side) with CD81, ICAM1 and CD9 at immunological synapses between antigen-presenting cells and T cells. Interacts with CD160. Interacts with LY6E. Interacts with LY6E (By similarity). The signaling subunit of immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a heterodimer with FCER1G, associates with the ligand binding subunit FCGR3A (via transmembrane domain); this interaction is a prerequisite for Fc receptor complex expression on the cell surface. P24161; Q9WU22: Ptpn4; NbExp=3; IntAct=EBI-7803400, EBI-7249866; P24161; P43404: Zap70; NbExp=4; IntAct=EBI-7803400, EBI-3862932; Cell membrane ; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=2; Name=CD-3-zeta; IsoId=P24161-1; Sequence=Displayed; Name=CD-3-eta; IsoId=P24161-2; Sequence=VSP_058346; CD3Z is expressed in normal lymphoid tissue and in peripheral blood mononuclear cells (PBMCs). Expressed also in retinal ganglion cells (PubMed:20188655). The ITAM domains mediate interaction with SHB. Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. CD3Z deletion causes severely defective thymocyte differentiation (PubMed:8223495). Absence of CD3Z also leads to altered dendritic structure and motility in developing retina (PubMed:20188655). Belongs to the CD3Z/FCER1G family. adaptive immune response immune system process transmembrane signaling receptor activity protein binding cytoplasm plasma membrane cell surface receptor signaling pathway membrane integral component of membrane interleukin-2 production T cell receptor complex alpha-beta T cell receptor complex identical protein binding protein homodimerization activity T cell receptor signaling pathway protein homotetramerization protein homotrimerization protein tyrosine kinase binding positive regulation of protein localization to cell surface uc007djn.1 uc007djn.2 uc007djn.3 uc007djn.4 
ENSMUST00000005923.7 Psmb4 ENSMUST00000005923.7 proteasome (prosome, macropain) subunit, beta type 4 (from RefSeq NM_008945.3) ENSMUST00000005923.1 ENSMUST00000005923.2 ENSMUST00000005923.3 ENSMUST00000005923.4 ENSMUST00000005923.5 ENSMUST00000005923.6 Lmp3 NM_008945 P99026 PSB4_MOUSE Q3THC0 Q3THI3 Q3U0S0 Q3UVQ4 Q62008 Q8BK27 Q91VV7 uc008qhe.1 uc008qhe.2 uc008qhe.3 uc008qhe.4 Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:16857966, PubMed:22341445). Forms a ternary complex with SMAD1 and OAZ1 before PSMB4 is incorporated into the 20S proteasome (By similarity). Interacts with PRPF19 (By similarity). Cytoplasm Nucleus Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. Detected in liver (at protein level). Up-regulated in liver tumor tissues (at protein level). Belongs to the peptidase T1B family. proteasome complex lipopolysaccharide binding negative regulation of inflammatory response to antigenic stimulus endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteolysis peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, beta-subunit complex proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process uc008qhe.1 uc008qhe.2 uc008qhe.3 uc008qhe.4 
ENSMUST00000005933.4 Klk1b16 ENSMUST00000005933.4 kallikrein 1-related peptidase b16 (from RefSeq NM_008454.3) ENSMUST00000005933.1 ENSMUST00000005933.2 ENSMUST00000005933.3 K1B16_MOUSE Klk-16 Klk16 NM_008454 P04071 uc009goj.1 uc009goj.2 uc009goj.3 uc009goj.4 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BG865287.1, J03877.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Reaction=Cleavage of the Leu-|-Leu bond in synthetic tetradecapeptide renin substrate, to produce angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes Bz-Arg-p-nitroanilide.; EC=3.4.21.54; Belongs to the peptidase S1 family. Kallikrein subfamily. regulation of systemic arterial blood pressure endopeptidase activity serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides secretory granule zymogen activation macromolecular complex uc009goj.1 uc009goj.2 uc009goj.3 uc009goj.4 
ENSMUST00000005950.12 Mmp12 ENSMUST00000005950.12 matrix metallopeptidase 12, transcript variant 1 (from RefSeq NM_008605.3) ENSMUST00000005950.1 ENSMUST00000005950.10 ENSMUST00000005950.11 ENSMUST00000005950.2 ENSMUST00000005950.3 ENSMUST00000005950.4 ENSMUST00000005950.5 ENSMUST00000005950.6 ENSMUST00000005950.7 ENSMUST00000005950.8 ENSMUST00000005950.9 MMP12_MOUSE Mme Mmel NM_008605 P34960 Q3TB28 Q3TBV6 Q3TBV9 Q3TD61 Q3U1S8 Q3U1S9 Q3U2R8 Q3UBC5 Q4FJM7 Q8BJ92 Q8BJB3 Q8BJB6 Q8BJB8 Q8BJB9 Q8VED6 uc009oci.1 uc009oci.2 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein have a diminished capacity to degrade extracellular matrix components, do not develop emphysema in response to long-term exposure to cigarette smoke, and exhibit impaired clearance and increased mortality upon bacterial infection. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]. May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity). Reaction=Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.; EC=3.4.24.65; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 4 Ca(2+) ions per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Secreted, extracellular space, extracellular matrix The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. Belongs to the peptidase M10A family. Sequence=AAA39526.1; Type=Erroneous initiation; Evidence=; Sequence=BAC40889.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter core promoter binding metalloendopeptidase activity calcium ion binding collagen binding extracellular region extracellular space nucleus cytoplasm proteolysis protein import into nucleus peptidase activity metallopeptidase activity zinc ion binding positive regulation of gene expression hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix wound healing, spreading of epidermal cells wound healing sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding regulation of defense response to virus by host positive regulation of epithelial cell proliferation involved in wound healing elastin catabolic process negative regulation of type I interferon-mediated signaling pathway positive regulation of type I interferon-mediated signaling pathway cellular response to virus regulation of trophoblast cell migration positive regulation of interferon-alpha secretion negative regulation of endothelial cell-matrix adhesion via fibronectin uc009oci.1 uc009oci.2 
ENSMUST00000005952.11 Slc30a4 ENSMUST00000005952.11 solute carrier family 30 (zinc transporter), member 4, transcript variant 1 (from RefSeq NM_011774.3) ENSMUST00000005952.1 ENSMUST00000005952.10 ENSMUST00000005952.2 ENSMUST00000005952.3 ENSMUST00000005952.4 ENSMUST00000005952.5 ENSMUST00000005952.6 ENSMUST00000005952.7 ENSMUST00000005952.8 ENSMUST00000005952.9 Lm NM_011774 O35149 O35154 Q3UYZ9 Slc30a4 ZNT4_MOUSE Znt4 uc008mba.1 uc008mba.2 uc008mba.3 uc008mba.4 Probable proton-coupled zinc ion antiporter mediating zinc import from cytoplasm potentially into the endocytic compartment (PubMed:9354792). Controls zinc deposition in milk (PubMed:9354792). Reaction=2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out); Xref=Rhea:RHEA:72627, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105; Evidence=; Homodimerization could regulate efficiency for zinc transport. Interacts with TMEM163 (By similarity). Endosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Note=Enriched in vesicles within the basal region of epithelial cells. Widely expressed. Highly expressed in the brain and in mammary epithelial cell lines. Note=Defect in Slc30a4 is the cause of the lethal milk (lm) phenotype. Mice with lm are defective in zinc transport into breast milk, due to a premature translation termination codon at position 297. Only homozygous mutant adults develop dermatitis, skin lesions, and hair loss due to a systemic zinc deficiency. Pups of any genotype suckled on homozygous mutant female also develop symptoms characteristic of nutritional zinc deficiency, including dermatitis, alopecia and stunted growth. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. zinc ion transmembrane transporter activity cytoplasm lysosome lysosomal membrane endosome late endosome plasma membrane ion transport cation transport zinc II ion transport cation transmembrane transporter activity response to toxic substance endosome membrane response to zinc ion membrane integral component of membrane cytoplasmic vesicle late endosome membrane zinc ion homeostasis transmembrane transport regulation of sequestering of zinc ion zinc II ion transmembrane transport uc008mba.1 uc008mba.2 uc008mba.3 uc008mba.4 
ENSMUST00000005953.11 Sqor ENSMUST00000005953.11 sulfide quinone oxidoreductase, transcript variant 2 (from RefSeq NM_001162503.1) ENSMUST00000005953.1 ENSMUST00000005953.10 ENSMUST00000005953.2 ENSMUST00000005953.3 ENSMUST00000005953.4 ENSMUST00000005953.5 ENSMUST00000005953.6 ENSMUST00000005953.7 ENSMUST00000005953.8 ENSMUST00000005953.9 NM_001162503 Q8BW20 Q91XA1 Q9D891 Q9R112 SQOR_MOUSE Sqor Sqrdl uc008mbh.1 uc008mbh.2 uc008mbh.3 uc008mbh.4 uc008mbh.5 Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione. Reaction=2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 = thiosulfate + ubiquinol-10; Xref=Rhea:RHEA:38359, ChEBI:CHEBI:15378, ChEBI:CHEBI:17359, ChEBI:CHEBI:29919, ChEBI:CHEBI:33542, ChEBI:CHEBI:46245, ChEBI:CHEBI:64183; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38360; Evidence=; Reaction=a quinone + glutathione + H(+) + hydrogen sulfide = a quinol + S-sulfanylglutathione; Xref=Rhea:RHEA:55156, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:29919, ChEBI:CHEBI:57925, ChEBI:CHEBI:58905, ChEBI:CHEBI:132124; EC=1.8.5.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55157; Evidence=; Reaction=glutathione + H(+) + hydrogen sulfide + ubiquinone-10 = S- sulfanylglutathione + ubiquinol-10; Xref=Rhea:RHEA:62608, ChEBI:CHEBI:15378, ChEBI:CHEBI:29919, ChEBI:CHEBI:46245, ChEBI:CHEBI:57925, ChEBI:CHEBI:58905, ChEBI:CHEBI:64183; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62609; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Mitochondrion Belongs to the SQRD family. mitochondrion mitochondrial inner membrane oxidoreductase activity quinone binding oxidation-reduction process sulfide oxidation, using sulfide:quinone oxidoreductase sulfide:quinone oxidoreductase activity hydrogen sulfide metabolic process FAD binding uc008mbh.1 uc008mbh.2 uc008mbh.3 uc008mbh.4 uc008mbh.5 
ENSMUST00000005954.9 Bloc1s6 ENSMUST00000005954.9 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin (from RefSeq NM_019788.3) A2ATW6 BL1S6_MOUSE ENSMUST00000005954.1 ENSMUST00000005954.2 ENSMUST00000005954.3 ENSMUST00000005954.4 ENSMUST00000005954.5 ENSMUST00000005954.6 ENSMUST00000005954.7 ENSMUST00000005954.8 NM_019788 P2 Pa Pldn Q3TUT4 Q91VG4 Q9R0C0 uc008mbf.1 uc008mbf.2 uc008mbf.3 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Interacts with SNAP47 (By similarity). Homodimer. Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Interacts with BLOC1S4, BLOC1S5, DTNBP1/BLOC1S7, F- actin, SNAP25 isoform 1 and STX12. Cytoplasm Membrane ; Peripheral membrane protein Note=It can exist as a soluble protein as well as a peripheral membrane protein. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9R0C0-1; Sequence=Displayed; Name=2; IsoId=Q9R0C0-2; Sequence=VSP_009295, VSP_009296; Name=3; IsoId=Q9R0C0-3; Sequence=Not described; Expressed in liver, kidney and spleen (at protein level). Ubiquitously expressed, with the highest expression levels observed in brain, heart, liver and kidney. Phosphorylated. Note=Defects in Pldn are the cause of the pallid (pa) phenotype that is characterized by an altered formation or function of intracellular storage granules in melanocytes, platelets, and lysosomes in kidney. Pallid mice have a prolonged bleeding time owing to the inability of immature platelet dense granules to accumulate normal amounts of ATP, ADP, and serotonin. Pa animals also suffer from pigment dilution, kidney lysosomal enzyme elevation and serum alpha1- antitrypsin activity deficiency. Finally, pallid mice exhibit defects in otolith formation that lead to balance abnormalities. [Isoform 2]: May be due to a competing acceptor splice site. [Isoform 3]: May be due to exon 2 skipping. Belongs to the BLOC1S6 family. protein binding cytoplasm endosome vesicle docking involved in exocytosis vesicle fusion blood coagulation anterograde axonal transport membrane extrinsic component of membrane transport vesicle melanocyte differentiation BLOC-1 complex neuron projection development melanosome transport positive regulation of natural killer cell activation secretion of lysosomal enzymes endosome to melanosome transport identical protein binding protein homodimerization activity pigmentation anterograde synaptic vesicle transport positive regulation of pigment cell differentiation actin filament binding membrane fusion axon cytoplasm SNARE complex uc008mbf.1 uc008mbf.2 uc008mbf.3 
ENSMUST00000005964.7 Adh5 ENSMUST00000005964.7 alcohol dehydrogenase 5 (class III), chi polypeptide, transcript variant 1 (from RefSeq NM_007410.3) Adh5 ENSMUST00000005964.1 ENSMUST00000005964.2 ENSMUST00000005964.3 ENSMUST00000005964.4 ENSMUST00000005964.5 ENSMUST00000005964.6 NM_007410 Q6P5I3 Q6P5I3_MOUSE uc008rnk.1 uc008rnk.2 uc008rnk.3 Reaction=20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20- oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:39799, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76624, ChEBI:CHEBI:76645; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39800; Evidence=; Reaction=20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH; Xref=Rhea:RHEA:39803, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76645, ChEBI:CHEBI:76647; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39804; Evidence=; Reaction=NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S- formylglutathione; Xref=Rhea:RHEA:19985, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57688, ChEBI:CHEBI:57945, ChEBI:CHEBI:58758; EC=1.1.1.284; Evidence= Reaction=NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S- formylglutathione; Xref=Rhea:RHEA:19981, ChEBI:CHEBI:15378, ChEBI:CHEBI:57688, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58758; EC=1.1.1.284; Evidence=; Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH; Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; Evidence=; Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH; Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Homodimer. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. fatty acid binding ethanol oxidation zinc ion binding fatty acid omega-oxidation oxidoreductase activity formaldehyde dehydrogenase activity metal ion binding response to redox state S-(hydroxymethyl)glutathione dehydrogenase activity oxidation-reduction process uc008rnk.1 uc008rnk.2 uc008rnk.3 
ENSMUST00000005975.8 Gpr108 ENSMUST00000005975.8 G protein-coupled receptor 108, transcript variant 4 (from RefSeq NM_001308074.1) ENSMUST00000005975.1 ENSMUST00000005975.2 ENSMUST00000005975.3 ENSMUST00000005975.4 ENSMUST00000005975.5 ENSMUST00000005975.6 ENSMUST00000005975.7 GP108_MOUSE Lustr2 NM_001308074 Q8BXE9 Q91WD0 Q925B1 uc008dei.1 uc008dei.2 uc008dei.3 uc008dei.4 uc008dei.5 May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response. (Microbial infection) Plays an essential function in adeno- associated virus (AAV) transduction, across multiple serotypes except AAV5. May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus. Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Golgi apparatus membrane; Multi-pass membrane protein Note=Colocalizes with TLR3, -7, -4, and -9. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91WD0-1; Sequence=Displayed; Name=2; IsoId=Q91WD0-2; Sequence=VSP_016607; High expression in spleen, lung, stomach, large and small intestine, and thymus. (Microbial infection) N- and C-terminal domains are essential for mediating AAV transduction. Deficient mice are viable and fertile and exhibit normal Mendelian segregation, however deficient mice exhibit increased LPS-induced mortality. TLR-mediated pro-inflammatory signaling are increased in embryonic fibroblasts and macrophages from Gpr108 deficient mice (PubMed:30332431). Depending on the AAV serotype used, 10-fold to 100-fold reduced expression for AAV is observed in Gpr108 knockout mice following retro-orbital administration (PubMed:31784416). Belongs to the LU7TM family. molecular_function cellular_component biological_process membrane integral component of membrane uc008dei.1 uc008dei.2 uc008dei.3 uc008dei.4 uc008dei.5 
ENSMUST00000005976.8 Tnfsf14 ENSMUST00000005976.8 tumor necrosis factor (ligand) superfamily, member 14 (from RefSeq NM_019418.4) ENSMUST00000005976.1 ENSMUST00000005976.2 ENSMUST00000005976.3 ENSMUST00000005976.4 ENSMUST00000005976.5 ENSMUST00000005976.6 ENSMUST00000005976.7 Light NM_019418 Q059Y9 Q9QYH9 TNF14_MOUSE uc008def.1 uc008def.2 uc008def.3 uc008def.4 Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (By similarity). Homotrimer. Interacts with TNFRSF14. Cell membrane ; Single-pass type II membrane protein [Tumor necrosis factor ligand superfamily member 14, soluble form]: Secreted The soluble form derives from the membrane form by proteolytic processing. Belongs to the tumor necrosis factor family. receptor binding cytokine activity tumor necrosis factor receptor binding protein binding extracellular region extracellular space plasma membrane apoptotic process immune response signal transduction positive regulation of T cell chemotaxis membrane integral component of membrane T cell costimulation identical protein binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of myoblast differentiation cellular response to mechanical stimulus positive regulation of NIK/NF-kappaB signaling positive regulation of myoblast fusion uc008def.1 uc008def.2 uc008def.3 uc008def.4 
ENSMUST00000006020.8 Cnga2 ENSMUST00000006020.8 cyclic nucleotide gated channel alpha 2, transcript variant 1 (from RefSeq NM_007724.3) CNGA2_MOUSE Cncg2 Cncg4 ENSMUST00000006020.1 ENSMUST00000006020.2 ENSMUST00000006020.3 ENSMUST00000006020.4 ENSMUST00000006020.5 ENSMUST00000006020.6 ENSMUST00000006020.7 NM_007724 Q62398 Q80XH6 uc009tkk.1 uc009tkk.2 uc009tkk.3 This gene encodes a transmembrane protein that is a subunit of the nucleotide-gated olfactory ion channel. Knock out of this gene affects development of the olfactory epithelium and olfactory bulb. [provided by RefSeq, May 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC048775.1, AK132574.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons. Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons (By similarity). Membrane; Multi-pass membrane protein. The C-terminal coiled-coil domain mediates trimerization of CNGA subunits. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily. It is uncertain whether Met-1 or Met-2 is the initiator. nucleotide binding ion channel activity intracellular cAMP activated cation channel activity intracellular cGMP activated cation channel activity voltage-gated potassium channel activity calmodulin binding plasma membrane ion transport potassium ion transport sensory perception of smell membrane integral component of membrane intracellular cyclic nucleotide activated cation channel complex cAMP binding cGMP binding ion transmembrane transport perikaryon response to stimulus protein homotetramerization protein heterotetramerization membrane depolarization transmembrane transport potassium ion transmembrane transport cation transmembrane transport uc009tkk.1 uc009tkk.2 uc009tkk.3 
ENSMUST00000006027.7 Reep5 ENSMUST00000006027.7 receptor accessory protein 5 (from RefSeq NM_007874.3) ENSMUST00000006027.1 ENSMUST00000006027.2 ENSMUST00000006027.3 ENSMUST00000006027.4 ENSMUST00000006027.5 ENSMUST00000006027.6 G3X8R0 G3X8R0_MOUSE NM_007874 Reep5 uc008eki.1 uc008eki.2 uc008eki.3 uc008eki.4 uc008eki.5 uc008eki.6 Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes. Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi- pass membrane protein Belongs to the DP1 family. membrane integral component of membrane endoplasmic reticulum tubular network uc008eki.1 uc008eki.2 uc008eki.3 uc008eki.4 uc008eki.5 uc008eki.6 
ENSMUST00000006029.11 Arhgap8 ENSMUST00000006029.11 Rho GTPase activating protein 8, transcript variant 4 (from RefSeq NM_001205334.1) ENSMUST00000006029.1 ENSMUST00000006029.10 ENSMUST00000006029.2 ENSMUST00000006029.3 ENSMUST00000006029.4 ENSMUST00000006029.5 ENSMUST00000006029.6 ENSMUST00000006029.7 ENSMUST00000006029.8 ENSMUST00000006029.9 NM_001205334 Q99JY7 Q9CXP4 RHG08_MOUSE uc057kul.1 uc057kul.2 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Highly expressed in skeletal muscle, lung and testis, and at lower levels in kidney, stomach and colon. Not detected in heart, liver, spleen, breast, brain, neonatal head or pancreas. Sequence=AAH10306.2; Type=Erroneous initiation; Evidence=; GTPase activator activity signal transduction positive regulation of GTPase activity uc057kul.1 uc057kul.2 
ENSMUST00000006035.13 Ergic3 ENSMUST00000006035.13 ERGIC and golgi 3, transcript variant 3 (from RefSeq NM_025516.5) B7ZCN9 ENSMUST00000006035.1 ENSMUST00000006035.10 ENSMUST00000006035.11 ENSMUST00000006035.12 ENSMUST00000006035.2 ENSMUST00000006035.3 ENSMUST00000006035.4 ENSMUST00000006035.5 ENSMUST00000006035.6 ENSMUST00000006035.7 ENSMUST00000006035.8 ENSMUST00000006035.9 ERGI3_MOUSE Erv46 NM_025516 Q6PGA7 Q9CQE7 Sdbcag84 uc008nlx.1 uc008nlx.2 uc008nlx.3 Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins alpha1-antitrypsin/SERPINA1 and HP/haptoglobin (By similarity). Forms homodimers (By similarity). May form a heteromeric complex composed of ERGIC1, ERGIC2 and ERGIC3 (By similarity). Within the complex, the interaction with ERGIC1 is direct (By similarity). Interacts with ERGIC1/ERGIC32 (By similarity). Interacts with ERGIC2, the interaction is required for the stable expression of both proteins (By similarity). Interacts with MARCHF2 (By similarity). Interacts with SERPINA1/alpha1-antitrypsin and HP/haptoglobin (By similarity). Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Cycles between the endoplasmic reticulum and the Golgi. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQE7-1; Sequence=Displayed; Name=2; IsoId=Q9CQE7-2; Sequence=VSP_019209, VSP_019210; Expression is particularly strong in liver, kidney and brain but is almost undetectable in heart. Belongs to the ERGIC family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER membrane integral component of membrane vesicle-mediated transport ER to Golgi transport vesicle integral component of Golgi membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment membrane uc008nlx.1 uc008nlx.2 uc008nlx.3 
ENSMUST00000006037.13 Ncoa2 ENSMUST00000006037.13 nuclear receptor coactivator 2, transcript variant a (from RefSeq NM_008678.3) E9QMH9 ENSMUST00000006037.1 ENSMUST00000006037.10 ENSMUST00000006037.11 ENSMUST00000006037.12 ENSMUST00000006037.2 ENSMUST00000006037.3 ENSMUST00000006037.4 ENSMUST00000006037.5 ENSMUST00000006037.6 ENSMUST00000006037.7 ENSMUST00000006037.8 ENSMUST00000006037.9 Grip1 NCOA2_MOUSE NM_008678 O09001 P97759 Q61026 Src2 Tif2 uc007aim.1 uc007aim.2 uc007aim.3 uc007aim.4 Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140, PubMed:31851938). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (PubMed:24529706). Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP (By similarity). Present in a complex containing CARM1 and EP300/P300 (PubMed:11997499, PubMed:10381882). Interacts (via C- terminus) with CREBBP (By similarity). Interacts (via LXXLL 1, 2 and 3 motifs) with RORA (via AF-2 motif) (PubMed:19039140). Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif) (PubMed:16148126). Interacts with APEX1 (By similarity). Interacts with BMAL1 (PubMed:24529706). Interacts with CARM1 (PubMed:10381882). Interacts with CASP8AP2 (PubMed:12477726). Interacts with CLOCK (PubMed:24529706). Interacts with DDX5 (By similarity). Interacts with ESR1 (By similarity). Interacts with HIF1A (By similarity). Interacts with NCOA1 (By similarity). Interacts with NR4A1/Nur77 (By similarity). Interacts with NR4A3; potentiates the activity of the NR4A3 (PubMed:12709428). Interacts with NR1H3 (By similarity). Interacts with NR3C1 (By similarity). Interacts with NR3C2 (PubMed:9111344). Interacts with PSMB9 (By similarity). Interacts with RARA (By similarity). Interacts with RXRA (By similarity). Interacts with RWDD3 (By similarity). Interacts with TTLL5/STAMP (By similarity). Q61026; Q4FZB7-1: KMT5B; Xeno; NbExp=4; IntAct=EBI-688662, EBI-15746366; Q61026; P04150-1: NR3C1; Xeno; NbExp=3; IntAct=EBI-688662, EBI-15750116; Nucleus Ubiquitous. Expressed in a circadian manner in the liver, brown adipose tissue (BAT), white adipose tissue (WAT), heart, skeletal muscle and suprachiasmatic nucleus (SCN) of the brain. Shows a higher expression during the light phase compared with the dark phase. Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant. The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding. Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently. Acetylated (PubMed:31851938). Deacetylation at Lys-780 by SIRT6 stimulates its ability to coactivate PPARA (PubMed:31851938). Animals show a glycogenopathy resembling to Von Gierke's disease with impaired growth, fasting hypoglycemia, and an increase in concentrations of triglycerides, cholesterol, free fatty acids, ketone bodies, uric acid and lactic acid in the plasma during fating. They also have increased liver glycogen stores and hepatic steatosis. Belongs to the SRC/p160 nuclear receptor coactivator family. Sequence=AAB61575.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding chromatin binding transcription coactivator activity receptor binding protein binding nucleus nucleoplasm cytoplasm rough endoplasmic reticulum Golgi apparatus microtubule regulation of transcription, DNA-templated circadian rhythm transcription factor binding regulation of gene expression regulation of glucose metabolic process postsynaptic density nuclear body ligand-dependent nuclear receptor binding aryl hydrocarbon receptor binding protein domain specific binding PDZ domain binding estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity thyroid hormone receptor coactivator activity dendrite response to progesterone cellular response to hormone stimulus circadian regulation of gene expression macromolecular complex progesterone receptor binding nuclear hormone receptor binding glucocorticoid receptor binding retinoic acid receptor binding neuronal cell body dendritic spine macromolecular complex binding locomotor rhythm negative regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription from RNA polymerase II promoter retinoid X receptor binding thyroid hormone receptor binding protein dimerization activity rhythmic process presynaptic active zone DNA polymerase binding cellular response to Thyroglobulin triiodothyronine positive regulation of glucocorticoid receptor signaling pathway uc007aim.1 uc007aim.2 uc007aim.3 uc007aim.4 
ENSMUST00000006046.5 Trh ENSMUST00000006046.5 thyrotropin releasing hormone (from RefSeq NM_009426.3) ENSMUST00000006046.1 ENSMUST00000006046.2 ENSMUST00000006046.3 ENSMUST00000006046.4 NM_009426 Q62361 Q7TMT4 TRH_MOUSE uc009cyw.1 uc009cyw.2 uc009cyw.3 This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The mouse proprotein contains five thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Disruption of this gene results in hypothyroidism, elevated thyroid-stimulating hormone levels, and hyperglycemia. [provided by RefSeq, Apr 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053493.1, AK010666.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01164131, SAMN01164139 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. Secreted. Specifically expressed in hypothalamus and testis. Belongs to the TRH family. response to hypoxia histamine metabolic process hormone activity protein binding extracellular region nucleus cytoplasm plasma membrane adult walking behavior thyrotropin-releasing hormone activity response to cold response to glucose hormone-mediated signaling pathway negative regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion response to organic cyclic compound secretory granule positive regulation of insulin secretion eating behavior response to ethanol response to corticosterone negative regulation of feeding behavior uc009cyw.1 uc009cyw.2 uc009cyw.3 
ENSMUST00000006053.13 Smpd4 ENSMUST00000006053.13 sphingomyelin phosphodiesterase 4, transcript variant 1 (from RefSeq NM_029945.4) ENSMUST00000006053.1 ENSMUST00000006053.10 ENSMUST00000006053.11 ENSMUST00000006053.12 ENSMUST00000006053.2 ENSMUST00000006053.3 ENSMUST00000006053.4 ENSMUST00000006053.5 ENSMUST00000006053.6 ENSMUST00000006053.7 ENSMUST00000006053.8 ENSMUST00000006053.9 Kiaa1418 NM_029945 NSMA3_MOUSE Q3TPE0 Q3TPP1 Q6ZPR5 Q8CBJ5 Q8CD12 Q8CD83 Q8R0J3 Q9CX74 uc007yll.1 uc007yll.2 uc007yll.3 uc007yll.4 Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:25180167). It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis. In skeletal muscle, mediates TNF-stimulated oxidant production (PubMed:25180167). [Isoform 1]: Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:295975; EC=3.1.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19254; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphatidylserine and tumor necrosis factor (TNF) (PubMed:25180167). Inhibited by scyphostatin (By similarity). Endoplasmic reticulum membrane ; Single-pass membrane protein Golgi apparatus membrane ; Single-pass membrane protein Nucleus envelope Cell membrane, sarcolemma Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=nSMase3a ; IsoId=Q6ZPR5-1; Sequence=Displayed; Name=2; Synonyms=nSMase3b ; IsoId=Q6ZPR5-2; Sequence=VSP_022485; Name=3; IsoId=Q6ZPR5-3; Sequence=VSP_022485, VSP_022486; Name=4; IsoId=Q6ZPR5-4; Sequence=VSP_022485, VSP_022487; Name=5; IsoId=Q6ZPR5-5; Sequence=VSP_022484, VSP_022485; [Isoform 1]: Expressed in skeletal muscle (at protein level). [Isoform 2]: Expressed in skeletal muscle but a lower levels than isoform 1 (at protein level). Sequence=BAC98164.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane in utero embryonic development sphingomyelin phosphodiesterase activity nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus trans-Golgi network sphingomyelin catabolic process membrane integral component of membrane hydrolase activity glycerophospholipid catabolic process ceramide biosynthetic process metal ion binding sphingomyelin phosphodiesterase D activity cellular response to tumor necrosis factor uc007yll.1 uc007yll.2 uc007yll.3 uc007yll.4 
ENSMUST00000006071.14 Otx1 ENSMUST00000006071.14 orthodenticle homeobox 1 (from RefSeq NM_011023.3) ENSMUST00000006071.1 ENSMUST00000006071.10 ENSMUST00000006071.11 ENSMUST00000006071.12 ENSMUST00000006071.13 ENSMUST00000006071.2 ENSMUST00000006071.3 ENSMUST00000006071.4 ENSMUST00000006071.5 ENSMUST00000006071.6 ENSMUST00000006071.7 ENSMUST00000006071.8 ENSMUST00000006071.9 NM_011023 Otx1 Q5SS54 Q5SS54_MOUSE uc007idy.1 uc007idy.2 uc007idy.3 This gene encodes a member of the bicoid subfamily of the paired homeobox transcription factor family. The encoded protein is critical to the maintenance and regionalization of the forebrain and midbrain during development. It may also have important functions in sense organ development, pituitary function, and in the regulation of blood cell production. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK042975.1, AK083671.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## Nucleus RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc007idy.1 uc007idy.2 uc007idy.3 
ENSMUST00000006094.6 Cyp2d26 ENSMUST00000006094.6 cytochrome P450, family 2, subfamily d, polypeptide 26 (from RefSeq NM_029562.2) A0A0R4IZY2 A0A0R4IZY2_MOUSE Cyp2d26 ENSMUST00000006094.1 ENSMUST00000006094.2 ENSMUST00000006094.3 ENSMUST00000006094.4 ENSMUST00000006094.5 NM_029562 uc007wzn.1 uc007wzn.2 uc007wzn.3 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane Microsome membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding female pregnancy membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding response to drug intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc007wzn.1 uc007wzn.2 uc007wzn.3 
ENSMUST00000006101.4 Itgae ENSMUST00000006101.4 integrin alpha E, epithelial-associated, transcript variant 1 (from RefSeq NM_008399.4) B1AUD5 ENSMUST00000006101.1 ENSMUST00000006101.2 ENSMUST00000006101.3 ITAE_MOUSE NM_008399 Q60677 uc007jzy.1 uc007jzy.2 uc007jzy.3 uc007jzy.4 Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7. Membrane; Single-pass type I membrane protein. The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. Belongs to the integrin alpha chain family. cell adhesion integrin-mediated signaling pathway integrin complex external side of plasma membrane membrane integral component of membrane metal ion binding uc007jzy.1 uc007jzy.2 uc007jzy.3 uc007jzy.4 
ENSMUST00000006103.9 Ctns ENSMUST00000006103.9 cystinosis, nephropathic, transcript variant 1 (from RefSeq NM_031251.4) Ctns ENSMUST00000006103.1 ENSMUST00000006103.2 ENSMUST00000006103.3 ENSMUST00000006103.4 ENSMUST00000006103.5 ENSMUST00000006103.6 ENSMUST00000006103.7 ENSMUST00000006103.8 NM_031251 Q542U5 Q542U5_MOUSE uc007kae.1 uc007kae.2 uc007kae.3 Reaction=H(+)(out) + L-cystine(out) = H(+)(in) + L-cystine(in); Xref=Rhea:RHEA:66172, ChEBI:CHEBI:15378, ChEBI:CHEBI:35491; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66173; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the cystinosin family. lysosome lysosomal membrane late endosome glutathione metabolic process brain development negative regulation of hydrogen peroxide biosynthetic process positive regulation of mitochondrial membrane potential L-cystine transmembrane transporter activity L-cystine transport membrane integral component of membrane intracellular membrane-bounded organelle intermediate filament cytoskeleton ATP metabolic process cognition negative regulation of reactive oxygen species biosynthetic process uc007kae.1 uc007kae.2 uc007kae.3 
ENSMUST00000006104.10 P2rx5 ENSMUST00000006104.10 purinergic receptor P2X, ligand-gated ion channel, 5, transcript variant 1 (from RefSeq NM_033321.4) ENSMUST00000006104.1 ENSMUST00000006104.2 ENSMUST00000006104.3 ENSMUST00000006104.4 ENSMUST00000006104.5 ENSMUST00000006104.6 ENSMUST00000006104.7 ENSMUST00000006104.8 ENSMUST00000006104.9 NM_033321 P2rx5 Q3UYI1 Q3UYI1_MOUSE uc007kaa.1 uc007kaa.2 uc007kaa.3 uc007kaa.4 Receptor for ATP that acts as a ligand-gated ion channel. Functional P2XRs are organized as homomeric and heteromeric trimers. Membrane ulti-pass membrane protein Belongs to the P2X receptor family. nucleotide binding purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity ion channel activity ATP binding GTP binding integral component of nuclear inner membrane cytosol plasma membrane integral component of plasma membrane ion transport cell surface receptor signaling pathway drug binding zinc ion binding membrane integral component of membrane neuronal action potential response to ATP purinergic nucleotide receptor signaling pathway regulation of skeletal muscle tissue regeneration protein homooligomerization excitatory postsynaptic potential cation transmembrane transport postsynapse uc007kaa.1 uc007kaa.2 uc007kaa.3 uc007kaa.4 
ENSMUST00000006105.7 Shpk ENSMUST00000006105.7 sedoheptulokinase (from RefSeq NM_029031.3) Carkl ENSMUST00000006105.1 ENSMUST00000006105.2 ENSMUST00000006105.3 ENSMUST00000006105.4 ENSMUST00000006105.5 ENSMUST00000006105.6 NM_029031 Q5SSE0 Q9D5J6 SHPK_MOUSE uc007kag.1 uc007kag.2 uc007kag.3 Acts as a modulator of macrophage activation through control of glucose metabolism. Reaction=ATP + sedoheptulose = ADP + D-sedoheptulose 7-phosphate + H(+); Xref=Rhea:RHEA:23844, ChEBI:CHEBI:15378, ChEBI:CHEBI:16802, ChEBI:CHEBI:30616, ChEBI:CHEBI:57483, ChEBI:CHEBI:456216; EC=2.7.1.14; Evidence=; Kinetic parameters: KM=0.19 mM for sedoheptulose ; Vmax=0.128 nmol/min/mg enzyme (at 30 degrees Celsius) ; Cytoplasm Up-regulated by IL-4 and IL-13. Down-regulated by LPS. Belongs to the FGGY kinase family. nucleotide binding ATP binding cytoplasm cytosol carbohydrate metabolic process pentose-phosphate shunt, non-oxidative branch kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor cellular response to interleukin-13 regulation of macrophage activation sedoheptulokinase activity regulation of inflammatory response cellular response to lipopolysaccharide cellular response to interleukin-4 uc007kag.1 uc007kag.2 uc007kag.3 
ENSMUST00000006112.7 Ephb3 ENSMUST00000006112.7 Eph receptor B3 (from RefSeq NM_010143.2) ENSMUST00000006112.1 ENSMUST00000006112.2 ENSMUST00000006112.3 ENSMUST00000006112.4 ENSMUST00000006112.5 ENSMUST00000006112.6 EPHB3_MOUSE Etk2 Mdk5 NM_010143 P54754 Q62214 Q91YS9 Sek4 uc007yrg.1 uc007yrg.2 uc007yrg.3 Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Cell membrane ; Single-pass type I membrane protein Cell projection, dendrite Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disk. Expressed by Paneth and progenitor cells in the crypts of the intestinal epithelium (at protein level). Expressed in myogenic progenitor cells (PubMed:27446912). Expressed during development in yolk sacs and by embryonic endothelial cells. Expressed in the developing intestinal epithelium at the bottom of the intervillus pockets where undifferentiated cells are allocated (at protein level). In myogenic progenitor cells, highly expressed during early development (11.5 dpc) and progressively repressed as developments proceeds (PubMed:27446912). Phosphorylated. Autophosphorylates upon ligand-binding. Autophosphorylation on Tyr-609 is required for interaction with SH2 domain-containing proteins (By similarity). Ubiquitinated by RNF186, mainly through 'Lys-48' and 'Lys-63'- linked polyubiquitin chains. Mice are viable and fertile and show no obvious abnormal behavior. The corpus callosum, the main axon tract connecting the left and right cerebral hemispheres, is not formed in a significant fraction of newborns. This is associated with defects in guidance of callosal axons across the midline. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. nucleotide binding angiogenesis urogenital system development protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity transmembrane-ephrin receptor activity ATP binding plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development axon guidance axonal fasciculation axon guidance receptor activity membrane integral component of membrane kinase activity phosphorylation cell migration transferase activity peptidyl-tyrosine phosphorylation central nervous system projection neuron axonogenesis corpus callosum development regulation of cell-cell adhesion dendrite retinal ganglion cell axon guidance substrate adhesion-dependent cell spreading cell projection regulation of GTPase activity receptor complex protein autophosphorylation ephrin receptor signaling pathway thymus development digestive tract morphogenesis regulation of axonogenesis positive regulation of synapse assembly palate development dendritic spine development dendritic spine morphogenesis uc007yrg.1 uc007yrg.2 uc007yrg.3 
ENSMUST00000006128.7 Rcn1 ENSMUST00000006128.7 reticulocalbin 1 (from RefSeq NM_009037.2) ENSMUST00000006128.1 ENSMUST00000006128.2 ENSMUST00000006128.3 ENSMUST00000006128.4 ENSMUST00000006128.5 ENSMUST00000006128.6 NM_009037 Q05186 Q3TVU3 RCN1_MOUSE Rca1 Rcn uc008lks.1 uc008lks.2 uc008lks.3 May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. Endoplasmic reticulum lumen. O-glycosylated. O-mannosylated by POMT1 and POMT2 and elongated by POMGNT1. This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium. Belongs to the CREC family. in utero embryonic development calcium ion binding endoplasmic reticulum endoplasmic reticulum lumen camera-type eye development metal ion binding uc008lks.1 uc008lks.2 uc008lks.3 
ENSMUST00000006136.11 Dnase1 ENSMUST00000006136.11 deoxyribonuclease I, transcript variant 1 (from RefSeq NM_010061.6) Dnase1 ENSMUST00000006136.1 ENSMUST00000006136.10 ENSMUST00000006136.2 ENSMUST00000006136.3 ENSMUST00000006136.4 ENSMUST00000006136.5 ENSMUST00000006136.6 ENSMUST00000006136.7 ENSMUST00000006136.8 ENSMUST00000006136.9 NM_010061 Q14BW6 Q14BW6_MOUSE uc007xzj.1 uc007xzj.2 uc007xzj.3 uc007xzj.4 Reaction=Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'- phosphooligonucleotide end-products.; EC=3.1.21.1; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Nucleus envelope Secreted Zymogen granule Belongs to the DNase I family. nuclease activity endonuclease activity deoxyribonuclease I activity deoxyribonuclease activity DNA catabolic process hydrolase activity nucleic acid phosphodiester bond hydrolysis uc007xzj.1 uc007xzj.2 uc007xzj.3 uc007xzj.4 
ENSMUST00000006137.9 Trap1 ENSMUST00000006137.9 TNF receptor-associated protein 1, transcript variant 2 (from RefSeq NR_152409.1) ENSMUST00000006137.1 ENSMUST00000006137.2 ENSMUST00000006137.3 ENSMUST00000006137.4 ENSMUST00000006137.5 ENSMUST00000006137.6 ENSMUST00000006137.7 ENSMUST00000006137.8 Hsp75 NR_152409 Q542I4 Q9CQN1 TRAP1_MOUSE uc007xzk.1 uc007xzk.2 uc007xzk.3 Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA. Mitochondrion Mitochondrion inner membrane Mitochondrion matrix Belongs to the heat shock protein 90 family. nucleotide binding RNA binding ATP binding nucleoplasm mitochondrion mitochondrial inner membrane mitochondrial intermembrane space mitochondrial matrix protein folding translational attenuation membrane protein kinase binding unfolded protein binding negative regulation of cellular respiration negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide uc007xzk.1 uc007xzk.2 uc007xzk.3 
ENSMUST00000006151.13 Tyrp1 ENSMUST00000006151.13 tyrosinase-related protein 1, transcript variant 1 (from RefSeq NM_031202.3) ENSMUST00000006151.1 ENSMUST00000006151.10 ENSMUST00000006151.11 ENSMUST00000006151.12 ENSMUST00000006151.2 ENSMUST00000006151.3 ENSMUST00000006151.4 ENSMUST00000006151.5 ENSMUST00000006151.6 ENSMUST00000006151.7 ENSMUST00000006151.8 ENSMUST00000006151.9 NM_031202 Q3UFS3 Q3UFS3_MOUSE RP23-372M15.1-001 Tyrp1 uc008tjr.1 uc008tjr.2 uc008tjr.3 uc008tjr.4 Reaction=2 5,6-dihydroxyindole-2-carboxylate + O2 = 2 H2O + 2 indole-5,6-quinone-2-carboxylate; Xref=Rhea:RHEA:68388, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16875, ChEBI:CHEBI:177869; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68389; Evidence=; Name=Cu(2+); Xref=ChEBI:CHEBI:29036; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Pigment biosynthesis; melanin biosynthesis. Melanosome membrane ; Single-pass type I membrane protein Belongs to the tyrosinase family. monophenol monooxygenase activity cytoplasm endosome membrane membrane integral component of membrane oxidoreductase activity clathrin-coated endocytic vesicle membrane metal ion binding positive regulation of melanin biosynthetic process oxidation-reduction process intracellular vesicle uc008tjr.1 uc008tjr.2 uc008tjr.3 uc008tjr.4 
ENSMUST00000006178.5 Kptn ENSMUST00000006178.5 kaptin (from RefSeq NM_133727.2) ENSMUST00000006178.1 ENSMUST00000006178.2 ENSMUST00000006178.3 ENSMUST00000006178.4 G3X8R1 G3X8R1_MOUSE Kptn NM_133727 uc009fgy.1 uc009fgy.2 uc009fgy.3 uc009fgy.4 actin binding actin filament organization actin cytoskeleton lamellipodium filamentous actin cellular response to amino acid starvation cellular response to glucose starvation actin filament binding protein localization to lysosome postsynaptic actin cytoskeleton negative regulation of TORC1 signaling uc009fgy.1 uc009fgy.2 uc009fgy.3 uc009fgy.4 
ENSMUST00000006181.7 Napa ENSMUST00000006181.7 N-ethylmaleimide sensitive fusion protein attachment protein alpha (from RefSeq NM_025898.4) ENSMUST00000006181.1 ENSMUST00000006181.2 ENSMUST00000006181.3 ENSMUST00000006181.4 ENSMUST00000006181.5 ENSMUST00000006181.6 NM_025898 Q543I3 Q9DB05 SNAA_MOUSE Snapa uc009fgw.1 uc009fgw.2 uc009fgw.3 Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Together with GNA12 promotes CDH5 localization to plasma membrane. Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2 (By similarity). Found in a complex with VAMP8 (By similarity). Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha (By similarity). Interacts with VTI1A (PubMed:9705316). Interacts with STX12 (By similarity). Interacts with GNA12 (via N-terminus); the interaction promotes CDH5 localization to plasma membrane (By similarity). Cell membrane ; Peripheral membrane protein Belongs to the SNAP family. SNARE binding soluble NSF attachment protein activity protein binding vacuolar membrane plasma membrane intracellular protein transport brain development regulation of synaptic vesicle priming protein transport membrane synaptic vesicle priming vesicle-mediated transport syntaxin binding neuron differentiation SNARE complex positive regulation of ATPase activity macromolecular complex disassembly synaptic transmission, glutamatergic SNARE complex disassembly myelin sheath macromolecular complex binding apical protein localization synaptobrevin 2-SNAP-25-syntaxin-1a complex presynapse postsynapse glutamatergic synapse uc009fgw.1 uc009fgw.2 uc009fgw.3 
ENSMUST00000006217.10 Snf8 ENSMUST00000006217.10 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae), transcript variant 7 (from RefSeq NR_189311.1) A2A6M2 D11Moh34 ENSMUST00000006217.1 ENSMUST00000006217.2 ENSMUST00000006217.3 ENSMUST00000006217.4 ENSMUST00000006217.5 ENSMUST00000006217.6 ENSMUST00000006217.7 ENSMUST00000006217.8 ENSMUST00000006217.9 NR_189311 Q9CZ28 SNF8_MOUSE uc007lbb.1 uc007lbb.2 uc007lbb.3 Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS25 and VPS36. SNF8 is essential for the stability of the ESCRT-II complex. ESCRT-II interacts with ELL. Interacts with TSG101 (via the C-terminal domain). Interacts with RILPL1 (via the N-terminal domain); which recruits ESCRT-II to the endosome membranes. Interacts with 14-3-3 proteins (By similarity). Cytoplasm Endosome membrane Nucleus Late endosome membrane Note=Recruited to the endosome membrane to participate in vesicle formation. Belongs to the SNF8 family. ESCRT II complex nucleus nucleoplasm transcription factor complex cytoplasm endosome cytosol plasma membrane regulation of transcription from RNA polymerase II promoter protein C-terminus binding transcription factor binding endosome membrane positive regulation of gene expression regulation of multivesicular body size involved in endosome transport protein transport membrane channel regulator activity late endosome membrane endocytic recycling regulation of protein catabolic process protein homodimerization activity protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway early endosome to late endosome transport positive regulation of protein catabolic process protein N-terminus binding perinuclear region of cytoplasm recycling endosome regulation of protein complex stability multivesicular body sorting pathway positive regulation of exosomal secretion regulation of viral budding via host ESCRT complex uc007lbb.1 uc007lbb.2 uc007lbb.3 
ENSMUST00000006221.14 Vps54 ENSMUST00000006221.14 VPS54 GARP complex subunit, transcript variant 1 (from RefSeq NM_139061.5) ENSMUST00000006221.1 ENSMUST00000006221.10 ENSMUST00000006221.11 ENSMUST00000006221.12 ENSMUST00000006221.13 ENSMUST00000006221.2 ENSMUST00000006221.3 ENSMUST00000006221.4 ENSMUST00000006221.5 ENSMUST00000006221.6 ENSMUST00000006221.7 ENSMUST00000006221.8 ENSMUST00000006221.9 NM_139061 Q5SPW0 Q8BPB3 Q8CFZ7 Q8CHL5 Q8R3R4 Q8R3X1 VPS54_MOUSE uc007ido.1 uc007ido.2 uc007ido.3 uc007ido.4 uc007ido.5 Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling. Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (By similarity). EIPR1 interacts with GARP complex and mediates its recruitment to the trans-Golgi network (By similarity). Interacts with VPS51 in an EIPR1-independent manner (By similarity). Golgi apparatus, trans-Golgi network Membrane Note=Associates with membranes in an EIPR1-independent manner. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SPW0-1; Sequence=Displayed; Name=2; IsoId=Q5SPW0-2; Sequence=VSP_013757; Note=Defects in Vps54 are the cause of wobbler phenotype (wr). Wr is autosomal recessive and is a spontaneous mutation discovered almost 50 years ago. It causes spinal muscular atrophy and defective spermiogenesis. Belongs to the VPS54 family. Sequence=AAH23474.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; GARP complex nucleoplasm Golgi apparatus trans-Golgi network cytosol Golgi to vacuole transport lysosomal transport protein transport syntaxin binding regulation of growth retrograde transport, endosome to Golgi perinuclear region of cytoplasm homeostasis of number of cells within a tissue musculoskeletal movement neurofilament cytoskeleton organization uc007ido.1 uc007ido.2 uc007ido.3 uc007ido.4 uc007ido.5 
ENSMUST00000006235.9 Ctsb ENSMUST00000006235.9 cathepsin B (from RefSeq NM_007798.3) CATB_MOUSE ENSMUST00000006235.1 ENSMUST00000006235.2 ENSMUST00000006235.3 ENSMUST00000006235.4 ENSMUST00000006235.5 ENSMUST00000006235.6 ENSMUST00000006235.7 ENSMUST00000006235.8 NM_007798 P10605 Q3UDW7 uc007uhh.1 uc007uhh.2 uc007uhh.3 This gene encodes a member of the peptidase C1 family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to generate the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. Homozygous knockout mice for this gene exhibit reduced pancreatic damage following induced pancreatitis and reduced hepatocyte apoptosis in a model of liver injury. Pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK083393.1, AK151790.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (PubMed:12782676). Has also been implicated in tumor invasion and metastasis (By similarity). Reaction=Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C- terminal dipeptides.; EC=3.4.22.1; Evidence=; Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Directly interacts with SHKBP1. Lysosome Melanosome Secreted, extracellular space Apical cell membrane ; Peripheral membrane protein ; Extracellular side Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells. Expressed in thyroid epithelial cells. Enlarged thyroid follicles, reduced extension of the thyroid epithelium, and increased levels of Tg/thyroglobulin in the thyroid follicles which fails to assemble into multilayers. Lysosomes are enlarged and CTSK/cathepsin K is absent from the thyroid follicle lumen and mis-localizes to the apical membrane of thyroid epithelial cells. Belongs to the peptidase C1 family. endopeptidase activity cysteine-type endopeptidase activity collagen binding extracellular region extracellular space nucleolus cytoplasm mitochondrion lysosome proteolysis peptidase activity cysteine-type peptidase activity external side of plasma membrane cell surface apical plasma membrane hydrolase activity collagen catabolic process epithelial cell differentiation kininogen binding peptide binding sarcolemma melanosome intracellular membrane-bounded organelle proteoglycan binding protein self-association macromolecular complex binding decidualization viral entry into host cell perinuclear region of cytoplasm regulation of catalytic activity proteolysis involved in cellular protein catabolic process negative regulation of cell death cellular response to thyroid hormone stimulus caveola uc007uhh.1 uc007uhh.2 uc007uhh.3 
ENSMUST00000006254.6 Tbcb ENSMUST00000006254.6 tubulin folding cofactor B, transcript variant 1 (from RefSeq NM_025548.4) Ckap1 ENSMUST00000006254.1 ENSMUST00000006254.2 ENSMUST00000006254.3 ENSMUST00000006254.4 ENSMUST00000006254.5 NM_025548 Q9CWR6 Q9D1E6 Q9DCZ6 TBCB_MOUSE uc009gds.1 uc009gds.2 uc009gds.3 uc009gds.4 Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (By similarity). Involved in regulation of tubulin heterodimer dissociation (PubMed:17184771). May function as a negative regulator of axonal growth (PubMed:17217416). Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state (By similarity). Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers (PubMed:17184771). Interacts with GAN. Interacts with DCTN1 (By similarity). Cytoplasm Cytoplasm, cytoskeleton Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone. Widely expressed with highest levels in brain. Broadly distributed throughout the neonate brain but restricted mainly to ependymary cells in the adult brain where it is concentrated in the cilia. In the embryo, expression increases at 12.5 dpc- 14.5 dpc. Levels are highest in pre- and postnatal stages which coincide with peaks of cerebral and cerebellar neurogenesis (at protein level). Phosphorylation by PAK1 is required for normal function. Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome. Mice display significantly longer axons than wild-type mice. Overexpression of Tbcb causes microtubule depolymerization, growth cone retraction and axonal damage followed by neuronal degeneration. Belongs to the TBCB family. protein binding cytoplasm cytosol cytoskeleton microtubule multicellular organism development nervous system development cell differentiation uc009gds.1 uc009gds.2 uc009gds.3 uc009gds.4 
ENSMUST00000006286.9 Inpp5k ENSMUST00000006286.9 inositol polyphosphate 5-phosphatase K (from RefSeq NM_008916.2) ENSMUST00000006286.1 ENSMUST00000006286.2 ENSMUST00000006286.3 ENSMUST00000006286.4 ENSMUST00000006286.5 ENSMUST00000006286.6 ENSMUST00000006286.7 ENSMUST00000006286.8 INP5K_MOUSE Inpp5k NM_008916 O09040 Pps Q8C5L6 Skip uc007kek.1 uc007kek.2 uc007kek.3 Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6- fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (By similarity). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (PubMed:22247557, PubMed:22751929). Reaction=1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate; Xref=Rhea:RHEA:19797, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58282, ChEBI:CHEBI:203600; EC=3.1.3.56; Evidence= Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + phosphate; Xref=Rhea:RHEA:43548, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:83416, ChEBI:CHEBI:83417; Evidence=; Reaction=1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo- inositol 1,3,4-trisphosphate + phosphate; Xref=Rhea:RHEA:11392, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57895, ChEBI:CHEBI:58414; EC=3.1.3.56; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol 4-phosphate) + phosphate; Xref=Rhea:RHEA:22764, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456; EC=3.1.3.36; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + phosphate; Xref=Rhea:RHEA:25528, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57658, ChEBI:CHEBI:57836; EC=3.1.3.86; Evidence=; Interacts with GPR78; necessary for INPP5K localization at the endoplasmic reticulum. Interacts with PAK1; competes with GPR78. Endoplasmic reticulum Cytoplasm Note=Following stimulation with EGF, translocates to membrane ruffles. Expressed in the skeletal muscle and the eye. Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. in utero embryonic development ruffle negative regulation of protein phosphorylation phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity vasopressin receptor activity protein binding nucleus cytoplasm endoplasmic reticulum trans-Golgi network cytosol plasma membrane regulation of glycogen biosynthetic process negative regulation of protein kinase activity G-protein coupled receptor signaling pathway negative regulation of peptidyl-threonine phosphorylation negative regulation of glucose transport membrane dephosphorylation inositol bisphosphate phosphatase activity hydrolase activity ruffle membrane response to insulin cellular response to insulin stimulus cellular response to hormone stimulus negative regulation of peptidyl-serine phosphorylation phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity phosphatidylinositol trisphosphate phosphatase activity phosphatidylinositol phosphate 5-phosphatase activity negative regulation of dephosphorylation positive regulation of urine volume glucose homeostasis neuron projection negative regulation of MAP kinase activity negative regulation by host of viral transcription negative regulation of glycogen biosynthetic process negative regulation of single stranded viral RNA replication via double stranded DNA intermediate negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated inositol trisphosphate phosphatase activity negative regulation of insulin receptor signaling pathway inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation perinuclear region of cytoplasm negative regulation of stress fiber assembly negative regulation of protein kinase B signaling negative regulation of calcium ion transport inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity cellular response to cAMP cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus protein localization to plasma membrane negative regulation of protein targeting to membrane ruffle assembly negative regulation of glycogen (starch) synthase activity positive regulation of renal water transport uc007kek.1 uc007kek.2 uc007kek.3 
ENSMUST00000006293.5 Crkl ENSMUST00000006293.5 v-crk avian sarcoma virus CT10 oncogene homolog-like, transcript variant 1 (from RefSeq NM_007764.5) CRKL_MOUSE Crkol ENSMUST00000006293.1 ENSMUST00000006293.2 ENSMUST00000006293.3 ENSMUST00000006293.4 NM_007764 P47941 Q3TQ18 Q8BGC5 uc007ykv.1 uc007ykv.2 uc007ykv.3 uc007ykv.4 This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In certain mouse genetic backgrounds this protein is essential for embryonic development. It is important for neural crest cell differentiation and survival and is proposed to play an important role in transducing the oncogenic signal of Bcr/Abl. Deletion of this gene in mouse mimics the phenotype of DiGeorge/velocardiofacial syndrome in human. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]. May mediate the transduction of intracellular signals. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4 (By similarity). Interacts with INPP5D/SHIP1 (PubMed:11031258). Interacts with BCAR1/CAS and NEDD9/HEF1 (By similarity). Phosphorylated on tyrosine. Phosphorylation is prominent during early development, but decreases at later embryonic stages and in newborn mice. Belongs to the CRK family. activation of MAPK activity regulation of cell growth blood vessel development urogenital system development neuron migration B cell apoptotic process phosphotyrosine binding negative regulation of protein phosphorylation positive regulation of protein phosphorylation regulation of leukocyte migration outflow tract morphogenesis protein binding nucleoplasm cytoplasm cytosol lipid metabolic process spermatogenesis single fertilization pattern specification process synapse assembly heart development positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway male gonad development animal organ morphogenesis anterior/posterior pattern specification regulation of gene expression negative regulation of gene expression dendrite development hippocampus development cerebral cortex development establishment of cell polarity neuromuscular junction macromolecular complex regulation of cell adhesion mediated by integrin helper T cell diapedesis cellular response to drug reelin-mediated signaling pathway identical protein binding synapse retinoic acid receptor signaling pathway thymus development regulation of dendrite development T cell receptor signaling pathway parathyroid gland development cell chemotaxis pharynx development positive regulation of ERK1 and ERK2 cascade cellular response to transforming growth factor beta stimulus response to fibroblast growth factor endothelin receptor signaling pathway activation of GTPase activity acetylcholine receptor signaling pathway cerebellar neuron development cellular response to interleukin-7 extrinsic component of postsynaptic membrane positive regulation of substrate adhesion-dependent cell spreading positive regulation of glial cell migration regulation of skeletal muscle acetylcholine-gated channel clustering cranial skeletal system development regulation of T cell migration uc007ykv.1 uc007ykv.2 uc007ykv.3 uc007ykv.4 
ENSMUST00000006301.11 Lrwd1 ENSMUST00000006301.11 leucine-rich repeats and WD repeat domain containing 1 (from RefSeq NM_027891.4) D3Z2P9 ENSMUST00000006301.1 ENSMUST00000006301.10 ENSMUST00000006301.2 ENSMUST00000006301.3 ENSMUST00000006301.4 ENSMUST00000006301.5 ENSMUST00000006301.6 ENSMUST00000006301.7 ENSMUST00000006301.8 ENSMUST00000006301.9 LRWD1 LRWD1_MOUSE NM_027891 Orca Q3TIG2 Q8BKI3 Q8BUI3 Q9DBW4 uc008zzy.1 uc008zzy.2 uc008zzy.3 uc008zzy.4 Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post- replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation (By similarity). Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. Integral component of the ORC complex (By similarity). Directly interacts with CDT1, GMNN and ORC2. Interacts with ORC2 only when non-ubiquitinated; this interaction prevents LRWD1 ubiquitination and degradation. Some of these interactions are regulated in a cell- cycle dependent manner. Interaction with ORC1 occurs predominantly during G1. Association with phosphorylated ORC1 during mitosis is not efficient. Interaction with CDT1 occurs during G1 phase, as well as during mitosis with phosphorylated CDT1. Interaction with GMNN occurs from G1/S to mitosis. Interaction with ORC2 is observed throughout the cell cycle. The stoichiometry of the ORCA/ORC/CDT1/GMNN complex is 1:1:1:2 (By similarity). Interacts with CUL4A and DDB1; this interaction may lead to ubiquitination (By similarity). Nucleus Chromosome, centromere Chromosome, telomere Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Chromosome, centromere, kinetochore Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3. Testis-specific. The entire WD repeat region is required for the interaction with ORC, CDT1 and GMNN, as well as for association with chromatin and for binding to histone H3 and H4 trimethylation marks H3K9me3 and H4K20me3 (By similarity). Centrosomal localization requires additional conformation. Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination leading to proteasomal degradation. Ubiquitination occurs within the WD repeats at the end of the G1 phase. Ubiquitination may be catalyzed by the CUL4-DDB1 E3 ubiquitin-protein ligase complex and other E3 ligases (By similarity). Belongs to the LRWD1 family. Reported to be testis-specific (PubMed:20180869). However the transcript is found in many tissues, suggesting that the protein is present in many tissues. Sequence=BAB23500.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=BAC34810.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; chromosome, centromeric region kinetochore condensed chromosome kinetochore chromosome, telomeric region chromatin binding nucleus nuclear origin of replication recognition complex chromosome pericentric heterochromatin nucleolus cytoplasm microtubule organizing center cytoskeleton DNA replication chromatin organization methyl-CpG binding telomeric heterochromatin methylated histone binding intracellular membrane-bounded organelle establishment of protein localization to chromatin uc008zzy.1 uc008zzy.2 uc008zzy.3 uc008zzy.4 
ENSMUST00000006311.13 Tead4 ENSMUST00000006311.13 TEA domain family member 4, transcript variant 1 (from RefSeq NM_011567.2) A2BDD5 ENSMUST00000006311.1 ENSMUST00000006311.10 ENSMUST00000006311.11 ENSMUST00000006311.12 ENSMUST00000006311.2 ENSMUST00000006311.3 ENSMUST00000006311.4 ENSMUST00000006311.5 ENSMUST00000006311.6 ENSMUST00000006311.7 ENSMUST00000006311.8 ENSMUST00000006311.9 NM_011567 P70282 Q61174 Q61175 Q62296 Q62298 TEAD4_MOUSE Tcf13r1 Tef3 Tefr1 uc009ede.1 uc009ede.2 This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. This factor may play a role in the embryonic development of skeletal muscle. Alternatively spliced transcripts encoding distinct isoforms, which are translated through the use of a non-AUG (AUU) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]. Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle. Interacts with WWTR1/TAZ (By similarity). Interacts with YAP1. Q62296; Q80V24: Vgll4; NbExp=3; IntAct=EBI-9253444, EBI-9253433; Q62296-1; Q99NC0: Vgll1; NbExp=4; IntAct=EBI-15985676, EBI-15985690; Nucleus. Event=Alternative splicing; Named isoforms=2; Name=Long; Synonyms=TEFR1A, ETFR-2A; IsoId=Q62296-1; Sequence=Displayed; Name=Short; Synonyms=TEFR1B, ETFR-2B; IsoId=Q62296-2; Sequence=VSP_006390; Preferentially expressed in lung and in skeletal muscle. By FGF-1, FGF-2, calf serum, platelet-derived growth factor- BB, and phorbol 12-myristate 13-acetate. Sequence=AAB12488.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAB12488.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development cell fate specification blastocyst formation trophectodermal cell fate commitment DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter embryo implantation protein-DNA complex hippo signaling sequence-specific DNA binding transcription regulatory region DNA binding cell fate commitment positive regulation of transcription from RNA polymerase II promoter positive regulation of stem cell population maintenance uc009ede.1 uc009ede.2 
ENSMUST00000006341.4 Prss16 ENSMUST00000006341.4 serine protease 16 (thymus) (from RefSeq NM_019429.2) ENSMUST00000006341.1 ENSMUST00000006341.2 ENSMUST00000006341.3 NM_019429 Q9QXE5 TSSP_MOUSE Tssp uc007prz.1 uc007prz.2 uc007prz.3 Protease that may play a role in T-cell development. Cytoplasmic vesicle. Note=Vesicular, either lysosomal or endosomal. Expressed predominantly in cortical thymic epithelial cells, with highest expression around vessels and the thymic capsule. Expressed in developing thymus at 14 to 18 dpc, with maximal expression at 16 dpc. Belongs to the peptidase S28 family. lysosome endosome proteolysis peptidase activity serine-type peptidase activity dipeptidyl-peptidase activity hydrolase activity cytoplasmic vesicle uc007prz.1 uc007prz.2 uc007prz.3 
ENSMUST00000006353.14 Cdkal1 ENSMUST00000006353.14 CDK5 regulatory subunit associated protein 1-like 1, transcript variant 1 (from RefSeq NM_144536.4) CDKAL_MOUSE ENSMUST00000006353.1 ENSMUST00000006353.10 ENSMUST00000006353.11 ENSMUST00000006353.12 ENSMUST00000006353.13 ENSMUST00000006353.2 ENSMUST00000006353.3 ENSMUST00000006353.4 ENSMUST00000006353.5 ENSMUST00000006353.6 ENSMUST00000006353.7 ENSMUST00000006353.8 ENSMUST00000006353.9 NM_144536 Q3TE97 Q3V3D2 Q5T0I5 Q8C4B0 Q91WE6 Q9CT69 uc007pyn.1 uc007pyn.2 uc007pyn.3 uc007pyn.4 Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. Reaction=[sulfur carrier]-SH + AH2 + N(6)-L- threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'- deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S- adenosyl-L-homocysteine; Xref=Rhea:RHEA:37075, Rhea:RHEA-COMP:10163, Rhea:RHEA-COMP:11092, Rhea:RHEA-COMP:14737, Rhea:RHEA-COMP:14739, ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319, ChEBI:CHEBI:17499, ChEBI:CHEBI:29917, ChEBI:CHEBI:57844, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64428, ChEBI:CHEBI:74418, ChEBI:CHEBI:74420; EC=2.8.4.5; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. ; Endoplasmic reticulum membrane ; Single-pass membrane protein Note=Is a tail-anchored protein that exploits the TCR40 assisted pathway for insertion into the endoplasmic reticulum. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q91WE6-1; Sequence=Displayed; Name=2; IsoId=Q91WE6-2; Sequence=VSP_027460; Name=3; IsoId=Q91WE6-3; Sequence=VSP_027457; Name=4; IsoId=Q91WE6-4; Sequence=VSP_027456, VSP_027458, VSP_027459; Name=5; IsoId=Q91WE6-5; Sequence=VSP_027454, VSP_027455; Expressed in pancreas, liver and skeletal muscle, especially in white muscle fibers. Belongs to the methylthiotransferase family. CDKAL1 subfamily. catalytic activity endoplasmic reticulum endoplasmic reticulum membrane rough endoplasmic reticulum tRNA modification tRNA processing membrane integral component of membrane transferase activity methylthiotransferase activity N6-threonylcarbomyladenosine methylthiotransferase activity tRNA methylthiolation metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase maintenance of translational fidelity uc007pyn.1 uc007pyn.2 uc007pyn.3 uc007pyn.4 
ENSMUST00000006362.4 Rhox6 ENSMUST00000006362.4 reproductive homeobox 6 (from RefSeq NM_008955.1) ENSMUST00000006362.1 ENSMUST00000006362.2 ENSMUST00000006362.3 NM_008955 O70238 O70238_MOUSE Psx1 Rhox6 uc009szg.1 uc009szg.2 uc009szg.3 Nucleus DNA binding cellular_component nucleus biological_process uc009szg.1 uc009szg.2 uc009szg.3 
ENSMUST00000006367.8 Htra1 ENSMUST00000006367.8 HtrA serine peptidase 1 (from RefSeq NM_019564.3) ENSMUST00000006367.1 ENSMUST00000006367.2 ENSMUST00000006367.3 ENSMUST00000006367.4 ENSMUST00000006367.5 ENSMUST00000006367.6 ENSMUST00000006367.7 HTRA1_MOUSE Htra NM_019564 Prss11 Q8BN04 Q8BN05 Q91WS3 Q9QZK6 Q9R118 uc009kau.1 uc009kau.2 uc009kau.3 uc009kau.4 Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF- binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, but it is unclear whether it leads to the proteolytic degradation of TGF-beta proteins themselves (PubMed:18551132) or not (PubMed:14973287). By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. Forms homotrimers. In the presence of substrate, may form higher-order multimers in a PDZ-independent manner (By similarity). Interacts with TGF-beta family members, including BMP4, TGFB1, TGFB2, activin A and GDF5. Cell membrane Secreted Cytoplasm, cytosol Note=Predominantly secreted. Also found associated with the plasma membrane. In the brain, mainly expressed in cortical areas both in glial cells and neurons (at protein level). In bones, deposited in the matrix, with higher level in newly formed bone compared to fully calcified bone (at protein level). Also expressed in the tendons (at protein level). In the articular cartilage, detected only in the deepest zone of the joint cartilage. Not detected in the chondrocytes of the growth plate (at protein level). In an experimental arthritis model, at early disease stages, up-regulated in articular chondrocytes in the deep layers of the cartilage (at protein level). As arthritis progresses, chondrocyte expression expands toward the surface. First detected at 10.5 dpc. At 11.5 dpc, in the developing heart, expressed in the atrioventricular endocardial cushion and the outflow tract (at protein level). At 14.5 dpc, strong expression in the outflow tracts, including valves. In the developing skeleton, expressed at 12.5 dpc in the vertebral column and limbs. At 14.5 dpc, expressed in rudiments of tendons and ligaments along the vertebrae, as well as in mesenchymal cells surrounding precartilage condensations. Not detected in precartilage condensations, nor in chondrocytes, but strongly expressed in ossification centers. At 17.5 dpc, in the hind limb, significant expression persists in tendons and ligaments, but expression in the forming joints is reduced. At this stage, weakly detected in the thin layer of articular surfaces. Postnatally, in long bones, expressed by terminally differentiated hypertrophic chondrocytes that are committed to degeneration and eventually replaced by bone, as well as by osteoblasts at late differentiation stages and by mature osteocytes. In the developing brain, expressed in specific regions of the neuroepithelium in the forebrain and hindbrain adjacent to the forming choroid plexus. From 17.5 dpc till birth, expressed in neurogenic areas including ventricular zones (at protein level). At 12.5 and 14.5 dpc, expressed in Muellerian duct cells and in the surrounding mesenchyme in both male and female gonads. In the lung, detected in the mesenchymal cells. Expressed at 12.5 dpc in abdominal skin, both in epidermis and dermis. Also expressed in the epithelium of developing whiskers at 14.5 dpc. At later stages, localized in the basal layer of epidermis and in the invading epidermal cells that formed the whisker rudiments (at protein level). 9 days after birth, detected in the whisker outer root sheet (at protein level). The IGFBP N-terminal domain mediates interaction with TSC2 substrate. Mutants mice exhibit reduced retinal capillary density, as compared to wild type animals, in all 3 retinal layers, nerve fiber layer, as well as inner and outer plexiform layers. Belongs to the peptidase S1C family. placenta development serine-type endopeptidase activity protein binding insulin-like growth factor binding extracellular region extracellular space cytoplasm cytosol plasma membrane proteolysis peptidase activity serine-type peptidase activity membrane hydrolase activity growth factor binding negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway identical protein binding positive regulation of epithelial cell proliferation negative regulation of defense response to virus chorionic trophoblast cell differentiation dentinogenesis uc009kau.1 uc009kau.2 uc009kau.3 uc009kau.4 
ENSMUST00000006377.13 Zbtb17 ENSMUST00000006377.13 zinc finger and BTB domain containing 17, transcript variant 1 (from RefSeq NM_009541.2) A2ADB9 ENSMUST00000006377.1 ENSMUST00000006377.10 ENSMUST00000006377.11 ENSMUST00000006377.12 ENSMUST00000006377.2 ENSMUST00000006377.3 ENSMUST00000006377.4 ENSMUST00000006377.5 ENSMUST00000006377.6 ENSMUST00000006377.7 ENSMUST00000006377.8 ENSMUST00000006377.9 NM_009541 Q60699 Q60821 ZBT17_MOUSE Zfp100 Znf151 uc008vol.1 uc008vol.2 uc008vol.3 uc008vol.4 Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 (By similarity). Homooligomerizes (via the BTB/POZ domain), multimerization is required for DNA binding. Binds to the C-terminal helix-loop-helix motif of MYC which inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Interacts (via the C-terminal zinc fingers) with GFI1; the interaction results in the recruitment of MYC to the CDKN1A/p21 and CDKN1B promoters and repression of transcription. Interacts with TRAF2, interfering with the binding of UBC13 to TRAF2, and inhibiting TRAF2 E3 ligase activity. Interacts with BCL6; the interaction inhibits ZBTB17 transactivation activity on target genes involved in cell cycle arrest. Interacts with ZBTB49; this interaction blocks ZBTB17-mediated repression of RB1 (By similarity). Q60821; Q07120: Gfi1; Xeno; NbExp=3; IntAct=EBI-11598394, EBI-4289236; Nucleus Found in all the embryonic and adult tissues examined. Expressed ubiquitously from early embryogenesis (6.5 dpc) to organogenesis, predominantly in neural and epithelial tissues. Undergoes 'Lys-48'-linked polyubiquitination at Lys-388 and Lys- 472 and subsequent proteasomal degradation in a TRAF2-dependent manner and upon TNFA stimulation. Mice produce inviable embryos which are severely retarded in early development and do not undergo normal gastrulation due to massive apoptosis of ectodermal cells around day 7.5. Belongs to the krueppel C2H2-type zinc-finger protein family. RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding gastrulation with mouth forming second nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus multicellular organism development ectoderm development transcription factor binding negative regulation of cell proliferation macromolecular complex protein-DNA complex positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of cell cycle arrest uc008vol.1 uc008vol.2 uc008vol.3 uc008vol.4 
ENSMUST00000006378.9 Clcnkb ENSMUST00000006378.9 chloride channel, voltage-sensitive Kb (from RefSeq NM_019701.2) A2ADB6 CLCKB_MOUSE Clckb Clcnk1l ENSMUST00000006378.1 ENSMUST00000006378.2 ENSMUST00000006378.3 ENSMUST00000006378.4 ENSMUST00000006378.5 ENSMUST00000006378.6 ENSMUST00000006378.7 ENSMUST00000006378.8 NM_019701 Q8VCF8 Q9WUB6 uc008voh.1 uc008voh.2 uc008voh.3 uc008voh.4 This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 4. This gene is syntenic with human CLCNKA (geneID:1187). [provided by RefSeq, Sep 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. May be the basolateral chloride channel mediating net chloride absorption in CTAL cells. Interacts with BSND. Forms heteromers with BSND in the thick ascending limb of Henle and more distal segments. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WUB6-1; Sequence=Displayed; Name=2; IsoId=Q9WUB6-2; Sequence=VSP_011757, VSP_011758; Specifically expressed in the kidney. All nephron segments expressing BSND also express CLCNK proreins. [Isoform 2]: Due to intron retention. Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily. voltage-gated ion channel activity voltage-gated chloride channel activity chloride channel activity protein binding plasma membrane integral component of plasma membrane ion transport chloride transport membrane integral component of membrane ion transmembrane transport chloride channel complex regulation of ion transmembrane transport identical protein binding metal ion binding transmembrane transport chloride transmembrane transport uc008voh.1 uc008voh.2 uc008voh.3 uc008voh.4 
ENSMUST00000006380.5 Fam131c ENSMUST00000006380.5 family with sequence similarity 131, member C (from RefSeq NM_001085513.2) A2ADB2 A2ADB2_MOUSE ENSMUST00000006380.1 ENSMUST00000006380.2 ENSMUST00000006380.3 ENSMUST00000006380.4 Fam131c Gm693 NM_001085513 uc008vod.1 uc008vod.2 uc008vod.3 uc008vod.4 Belongs to the FAM131 family. molecular_function cellular_component biological_process uc008vod.1 uc008vod.2 uc008vod.3 uc008vod.4 
ENSMUST00000006392.3 Serpinb9b ENSMUST00000006392.3 serine (or cysteine) peptidase inhibitor, clade B, member 9b (from RefSeq NM_011452.3) ENSMUST00000006392.1 ENSMUST00000006392.2 NM_011452 O08802 Q9DAV6 Q9DAV6_MOUSE Serpinb9b uc007qaa.1 uc007qaa.2 uc007qaa.3 uc007qaa.4 Belongs to the serpin family. Ov-serpin subfamily. T cell mediated cytotoxicity serine-type endopeptidase inhibitor activity protein binding extracellular space cytoplasm negative regulation of endopeptidase activity uc007qaa.1 uc007qaa.2 uc007qaa.3 uc007qaa.4 
ENSMUST00000006397.7 Epor ENSMUST00000006397.7 erythropoietin receptor, transcript variant 4 (from RefSeq NR_177941.1) ENSMUST00000006397.1 ENSMUST00000006397.2 ENSMUST00000006397.3 ENSMUST00000006397.4 ENSMUST00000006397.5 ENSMUST00000006397.6 Epor NR_177941 Q3UTV9 Q3UTV9_MOUSE uc009ond.1 uc009ond.2 uc009ond.3 Receptor for erythropoietin. Forms homodimers on EPO stimulation. Membrane Belongs to the type I cytokine receptor family. Type 1 subfamily. transmembrane signaling receptor activity cytokine receptor activity erythropoietin receptor activity membrane integral component of membrane cytokine-mediated signaling pathway erythropoietin-mediated signaling pathway identical protein binding uc009ond.1 uc009ond.2 uc009ond.3 
ENSMUST00000006403.7 Ccdc159 ENSMUST00000006403.7 coiled-coil domain containing 159, transcript variant 2 (from RefSeq NM_025977.3) CC159_MOUSE ENSMUST00000006403.1 ENSMUST00000006403.2 ENSMUST00000006403.3 ENSMUST00000006403.4 ENSMUST00000006403.5 ENSMUST00000006403.6 NM_025977 Q0VBB7 Q8C963 Q9CXZ5 Q9D4W5 uc009omx.1 uc009omx.2 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C963-1; Sequence=Displayed; Name=2; IsoId=Q8C963-2; Sequence=VSP_033427; Name=3; IsoId=Q8C963-3; Sequence=VSP_033428, VSP_033429; molecular_function cellular_component biological_process uc009omx.1 uc009omx.2 
ENSMUST00000006424.8 Mob1b ENSMUST00000006424.8 MOB kinase activator 1B (from RefSeq NM_026735.2) ENSMUST00000006424.1 ENSMUST00000006424.2 ENSMUST00000006424.3 ENSMUST00000006424.4 ENSMUST00000006424.5 ENSMUST00000006424.6 ENSMUST00000006424.7 MOB1B_MOUSE Mobkl1a NM_026735 Q8BPB0 uc008yaf.1 uc008yaf.2 uc008yaf.3 Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L (By similarity). Binds STK38L. Interacts with LATS1 and LATS2 (By similarity). Cytoplasm Nucleus Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. Belongs to the MOB1/phocein family. nucleus nucleolus cytoplasm cytosol kinase activator activity kinase binding regulation of protein autophosphorylation positive regulation of kinase activity hippo signaling metal ion binding uc008yaf.1 uc008yaf.2 uc008yaf.3 
ENSMUST00000006431.8 Atp6v1b1 ENSMUST00000006431.8 ATPase, H+ transporting, lysosomal V1 subunit B1 (from RefSeq NM_134157.3) Atp6b1 ENSMUST00000006431.1 ENSMUST00000006431.2 ENSMUST00000006431.3 ENSMUST00000006431.4 ENSMUST00000006431.5 ENSMUST00000006431.6 ENSMUST00000006431.7 NM_134157 Q6P6I3 Q8C3L6 Q91YH6 VATB1_MOUSE uc009coc.1 uc009coc.2 uc009coc.3 Non-catalytic subunit of the V1 complex of vacuolar(H+)- ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:16174750, PubMed:23028982). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential for the proper assembly and activity of V-ATPase (By similarity). In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification (PubMed:16174750). Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium (PubMed:23028982). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Forms a complex with NHERF1 and SCL4A7 (By similarity). Apical cell membrane Basolateral cell membrane Highly expressed in the kidney; found in early distal nephron, encompassing thick ascending limbs and distal convoluted tubules and in the alpha-intercalated cells of the cortical collecting ducts (at protein level) (PubMed:14585495, PubMed:29993276). Expressed in the olfactory epithelium (at protein level) (PubMed:23028982). Expressed at lower levels in the testis (PubMed:14585495). The PDZ-binding motif mediates interactions with NHERF1 and SCL4A7. Mice show a higher urinary pH and a more severe metabolic acidosis after oral acid challenge in comparison to wild-type littermates (PubMed:16174750). Mice show diminished innate avoidance behavior (revealed as a decrease in freezing time and an increase in the number of sniffs in the presence of trimethyl-thiazoline) and diminished innate appetitive behavior (a decrease in time spent investigating the urine of the opposite sex) (PubMed:23028982). Belongs to the ATPase alpha/beta chains family. ossification renal water homeostasis renal sodium ion transport ATP binding cytoplasm cytosol microvillus prostaglandin metabolic process ion transport regulation of pH excretion sensory perception of sound synaptic vesicle regulation of gene expression hydrogen ion transmembrane transporter activity membrane basolateral plasma membrane apical plasma membrane lateral plasma membrane vacuolar proton-transporting V-type ATPase complex adult behavior proton-transporting V-type ATPase, V1 domain renal sodium excretion olfactory behavior macromolecular complex binding pH reduction ATP metabolic process chloride ion homeostasis calcium ion homeostasis potassium ion homeostasis extrinsic component of synaptic vesicle membrane hydrogen ion transmembrane transport inner ear morphogenesis uc009coc.1 uc009coc.2 uc009coc.3 
ENSMUST00000006435.8 Atp6v1b2 ENSMUST00000006435.8 ATPase, H+ transporting, lysosomal V1 subunit B2 (from RefSeq NM_007509.3) Atp6b2 ENSMUST00000006435.1 ENSMUST00000006435.2 ENSMUST00000006435.3 ENSMUST00000006435.4 ENSMUST00000006435.5 ENSMUST00000006435.6 ENSMUST00000006435.7 NM_007509 O09045 P50517 P62814 Q3TG74 Q3TL62 Q3TVK6 Q3TWR0 Q3U791 Q3U7C8 Q3U9Z0 Q3UAW7 VATB2_MOUSE Vat2 uc009lwx.1 uc009lwx.2 uc009lwx.3 uc009lwx.4 uc009lwx.5 Non-catalytic subunit of the V1 complex of vacuolar(H+)- ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:17898041). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (PubMed:17898041). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Apical cell membrane lanosome Cytoplasm toplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein Kidney; found in early distal nephron, encompassing thick ascending limbs and distal convoluted tubules and in the alpha- intercalated cells of the cortical collecting ducts (at protein level) (PubMed:16174750, PubMed:29993276, PubMed:17898041, PubMed:15013950). Expressed in epididymal clear cells (at protein level) (PubMed:15013950). Mainly expressed in the organ of Corti and spiral ganglion neurons, in both the early postnatal cochlea (P2) and the adult cochlea (P30) (PubMed:24913193). Morpholino knockdown in the whole cochlea, especially in hair cells and spiral ganglion neurons causes a dose- dependent hearing loss. Belongs to the ATPase alpha/beta chains family. Sequence=BAE30303.1; Type=Erroneous initiation; Evidence=; Sequence=BAE30526.1; Type=Erroneous initiation; Evidence=; Sequence=BAE31441.1; Type=Erroneous initiation; Evidence=; ruffle ATP binding cytoplasm cytosol plasma membrane microvillus ion transport endomembrane system membrane integral component of membrane apical plasma membrane hydrolase activity proton-transporting V-type ATPase, V1 domain melanosome myelin sheath intracellular membrane-bounded organelle ATP metabolic process hydrogen ion transmembrane transport uc009lwx.1 uc009lwx.2 uc009lwx.3 uc009lwx.4 uc009lwx.5 
ENSMUST00000006444.9 Tep1 ENSMUST00000006444.9 telomerase associated protein 1 (from RefSeq NM_009351.2) ENSMUST00000006444.1 ENSMUST00000006444.2 ENSMUST00000006444.3 ENSMUST00000006444.4 ENSMUST00000006444.5 ENSMUST00000006444.6 ENSMUST00000006444.7 ENSMUST00000006444.8 NM_009351 P97499 TEP1_MOUSE Tp1 uc007tlt.1 uc007tlt.2 uc007tlt.3 Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (By similarity). Also a component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport (PubMed:11149928). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle (PubMed:11149928). Associated component of the telomerase holoenzyme complex (By similarity). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs) (PubMed:11149928, PubMed:9020079). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs (PubMed:11149928, PubMed:9020079). Nucleus Chromosome, telomere. Ubiquitous. nucleotide binding telomere maintenance via recombination chromosome, telomeric region p53 binding telomerase activity RNA binding ATP binding nucleus chromosome telomerase holoenzyme complex cytoplasm RNA-dependent DNA biosynthetic process nuclear matrix enzyme binding telomerase RNA binding ribonucleoprotein complex telomere maintenance via telomerase uc007tlt.1 uc007tlt.2 uc007tlt.3 
ENSMUST00000006451.8 Ttc5 ENSMUST00000006451.8 tetratricopeptide repeat domain 5, transcript variant 3 (from RefSeq NM_001360545.1) ENSMUST00000006451.1 ENSMUST00000006451.2 ENSMUST00000006451.3 ENSMUST00000006451.4 ENSMUST00000006451.5 ENSMUST00000006451.6 ENSMUST00000006451.7 NM_001360545 Q3TTN5 Q3TZL6 Q99LG4 Strap TTC5_MOUSE Ttc5 uc007tlm.1 uc007tlm.2 uc007tlm.3 uc007tlm.4 Cofactor involved in the regulation of various cellular mechanisms such as actin regulation, autophagy, chromatin regulation and DNA repair (PubMed:11511361, PubMed:15448695, PubMed:18451878, PubMed:30420355). In physiological conditions, interacts with cofactor JMY in the cytoplasm which prevents JMY's actin nucleation activity and ability to activate the Arp2/3 complex (PubMed:30420355). Acts as a negative regulator of nutrient stress-induced autophagy by inhibiting JMY's interaction with MAP1LC3B, thereby preventing autophagosome formation (PubMed:30420355). Involves in tubulin autoregulation by promoting its degradation in response to excess soluble tubulin (By similarity). To do so, associates with the active ribosome near the ribosome exit tunnel and with nascent tubulin polypeptides early during their translation, triggering tubulin mRNA-targeted degradation (By similarity). Following DNA damage, phosphorylated by DNA damage responsive protein kinases ATM and CHEK2, leading to its nuclear accumulation and stability (PubMed:15448695, PubMed:18833288). Nuclear TTC5/STRAP promotes the assembly of a stress-responsive p53/TP53 coactivator complex, which includes the coactivators JMY and p300, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361). Also recruits arginine methyltransferase PRMT5 to p53/TP53 when DNA is damaged, allowing PRMT5 to methylate p53/TP53 (PubMed:19011621). In DNA stress conditions, also prevents p53/TP53 degradation by E3 ubiquitin ligase MDM2 (PubMed:11511361). Upon heat- shock stress, forms a chromatin-associated complex with heat-shock factor 1 HSF1 and p300/EP300 to stimulate heat-shock-responsive transcription, thereby increasing cell survival (PubMed:18451878). Mitochondrial TTC5/STRAP interacts with ATP synthase subunit beta ATP5F1B which decreased ATP synthase activity and lowers mitochondrial ATP production, thereby regulating cellular respiration and mitochondrial-dependent apoptosis (PubMed:25168243). Mitochondrial TTC5/STRAP also regulates p53/TP53-mediated apoptosis (PubMed:25168243). Interacts with JMY and p300/EP300; the interaction occurs in the nucleus and augments the association between JMY and p300/EP300 in response to DNA damage (PubMed:11511361, PubMed:15448695). Interacts with PRMT5; the interaction is DNA damage-dependent and promotes PRMT5 interaction with p53/TP53 and subsequent methylation (PubMed:19011621). Forms a complex with HSF1 and p300/EP300; these interactions augment chromatin-bound HSF1 and p300/EP300 histone acetyltransferase activity, resulting in enhanced heat-shock-responsive transcription (PubMed:18451878). Interacts with JMY; the interaction occurs in the cytoplasm and results in the inhibition of JYM's nucleation activity (PubMed:30420355). Interacts with ribosome-coding tubulin (via 60S subunit 28S rRNA and protein uL24/RPL26) and the N-terminal of nascent tubulin polypeptide (via alpha-tubulin MREC motif and beta-tubulin MREI motif); these interactions result in tubulin mRNA-targeted degradation (By similarity). Interacts with ATP5F1B; the interaction occurs in the mitochondria and results in ATP production decrease (PubMed:25168243). Interacts with p53/TP53; the interaction occurs in the mitochondria and results in increased apoptosis (PubMed:25168243). Q99LG4; Q3UA06: Trip13; NbExp=2; IntAct=EBI-21183045, EBI-308990; Nucleus toplasm toplasmic vesicle Mitochondrion matrix Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm (PubMed:15448695). Nuclear localization may be necessary for DNA damage-dependent stabilization of the protein (PubMed:15448695, PubMed:18833288). Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Stress-responsive protein (PubMed:11511361, PubMed:18833288). Induced upon UV or ionizing irradiation (at protein level) (PubMed:11511361). Induced upon heat-shock stress (at protein level) (PubMed:18451878). The tetratricopep-repeat (TPR) motifs may function as protein interaction domains. Phosphorylation by ATM kinase induces nuclear accumulation while interfering with nuclear export, and phosphorylation by CHEK2 kinase enhances nuclear stability. DNA binding chromatin binding protein binding nucleus nucleoplasm cytoplasm DNA repair cellular response to DNA damage stimulus positive regulation of transcription from RNA polymerase II promoter uc007tlm.1 uc007tlm.2 uc007tlm.3 uc007tlm.4 
ENSMUST00000006462.14 Aamp ENSMUST00000006462.14 angio-associated migratory protein, transcript variant 2 (from RefSeq NM_146110.3) Aamp ENSMUST00000006462.1 ENSMUST00000006462.10 ENSMUST00000006462.11 ENSMUST00000006462.12 ENSMUST00000006462.13 ENSMUST00000006462.2 ENSMUST00000006462.3 ENSMUST00000006462.4 ENSMUST00000006462.5 ENSMUST00000006462.6 ENSMUST00000006462.7 ENSMUST00000006462.8 ENSMUST00000006462.9 NM_146110 Q3TJ22 Q3TJ22_MOUSE uc007blr.1 uc007blr.2 uc007blr.3 cytosol heparin binding cell surface microtubule cytoskeleton ribosomal large subunit biogenesis intercellular bridge unfolded protein binding uc007blr.1 uc007blr.2 uc007blr.3 
ENSMUST00000006476.6 Upk1a ENSMUST00000006476.6 uroplakin 1A (from RefSeq NM_026815.2) ENSMUST00000006476.1 ENSMUST00000006476.2 ENSMUST00000006476.3 ENSMUST00000006476.4 ENSMUST00000006476.5 NM_026815 Q9D132 UPK1A_MOUSE uc009gfk.1 uc009gfk.2 uc009gfk.3 uc009gfk.4 Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity). Homodimer; disulfide-linked. Interacts with uroplakin-2 (UPK2) (By similarity). Binds to uropathogenic E.coli fimH. Membrane; Multi-pass membrane protein. Belongs to the tetraspanin (TM4SF) family. protein binding endoplasmic reticulum plasma membrane integral component of plasma membrane cell surface membrane integral component of membrane apical plasma membrane epithelial cell differentiation protein homodimerization activity protein oligomerization uc009gfk.1 uc009gfk.2 uc009gfk.3 uc009gfk.4 
ENSMUST00000006478.10 Tmem147 ENSMUST00000006478.10 transmembrane protein 147 (from RefSeq NM_027215.2) ENSMUST00000006478.1 ENSMUST00000006478.2 ENSMUST00000006478.3 ENSMUST00000006478.4 ENSMUST00000006478.5 ENSMUST00000006478.6 ENSMUST00000006478.7 ENSMUST00000006478.8 ENSMUST00000006478.9 NM_027215 Q8CI89 Q9CQG6 Q9D8F0 TM147_MOUSE Tmem147 uc009gga.1 uc009gga.2 uc009gga.3 Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane. Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO (NOMO1, NOMO2 or NOMO3) and TMEM147. The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex. Interacts with CHRM3, CHRM1 and AVPR2. Interacts with LBR; promoting LBR localization to the nucleus inner membrane. Interacts with DHCR7. Endoplasmic reticulum membrane ; Multi-pass membrane protein Nucleus membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQG6-1; Sequence=Displayed; Name=2; IsoId=Q9CQG6-2; Sequence=VSP_022328, VSP_022329; Expressed in cerebral cortex, submandibular gland, hypothalamus, pancreas, liver, and ileum. Belongs to the TMEM147 family. Sequence=BAB25453.1; Type=Frameshift; Evidence=; molecular_function endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane macromolecular complex uc009gga.1 uc009gga.2 uc009gga.3 
ENSMUST00000006496.15 Rps9 ENSMUST00000006496.15 ribosomal protein S9, transcript variant 1 (from RefSeq NM_029767.3) ENSMUST00000006496.1 ENSMUST00000006496.10 ENSMUST00000006496.11 ENSMUST00000006496.12 ENSMUST00000006496.13 ENSMUST00000006496.14 ENSMUST00000006496.2 ENSMUST00000006496.3 ENSMUST00000006496.4 ENSMUST00000006496.5 ENSMUST00000006496.6 ENSMUST00000006496.7 ENSMUST00000006496.8 ENSMUST00000006496.9 NM_029767 Q3UBF1 Q6ZWN5 Q8K2D1 RS9_MOUSE uc009ewa.1 uc009ewa.2 uc009ewa.3 Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Component of the small ribosomal subunit (PubMed:36517592). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Cytoplasm Nucleus, nucleolus Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Belongs to the universal ribosomal protein uS4 family. RNA binding structural constituent of ribosome nucleolus cytoplasm ribosome translation positive regulation of cell proliferation small ribosomal subunit rRNA binding cytosolic small ribosomal subunit translation regulator activity synapse positive regulation of translational fidelity ribonucleoprotein complex 5.8S rRNA binding uc009ewa.1 uc009ewa.2 uc009ewa.3 
ENSMUST00000006523.12 Crip1 ENSMUST00000006523.12 cysteine-rich protein 1 (from RefSeq NM_007763.3) CRIP1_MOUSE Crip ENSMUST00000006523.1 ENSMUST00000006523.10 ENSMUST00000006523.11 ENSMUST00000006523.2 ENSMUST00000006523.3 ENSMUST00000006523.4 ENSMUST00000006523.5 ENSMUST00000006523.6 ENSMUST00000006523.7 ENSMUST00000006523.8 ENSMUST00000006523.9 NM_007763 P04006 P63254 Q3THF0 uc007pfz.1 uc007pfz.2 uc007pfz.3 Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. AT DNA binding cytoplasm zinc ion binding DNA binding, bending intrinsic apoptotic signaling pathway in response to DNA damage response to zinc ion regulation of gene expression peptide binding metal ion binding cellular response to antibiotic cellular response to UV-B uc007pfz.1 uc007pfz.2 uc007pfz.3 
ENSMUST00000006544.9 Gcat ENSMUST00000006544.9 glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase), transcript variant 1 (from RefSeq NM_013847.4) ENSMUST00000006544.1 ENSMUST00000006544.2 ENSMUST00000006544.3 ENSMUST00000006544.4 ENSMUST00000006544.5 ENSMUST00000006544.6 ENSMUST00000006544.7 ENSMUST00000006544.8 KBL_MOUSE Kbl NM_013847 O88986 uc007wse.1 uc007wse.2 uc007wse.3 uc007wse.4 Pyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA. Catalyzes the second reaction step on the main metabolic degradation pathway for L-threonine. Reaction=acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA; Xref=Rhea:RHEA:20736, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57305, ChEBI:CHEBI:78948; EC=2.3.1.29; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:20738; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Amino-acid degradation; L-threonine degradation via oxydo- reductase pathway; glycine from L-threonine: step 2/2. Mitochondrion Nucleus Note=Translocates to the nucleus upon cold and osmotic stress. Present in the placenta, brain and liver during embryonic development (at protein level). No visible phenotype. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. molecular_function catalytic activity nucleus nucleoplasm mitochondrion mitochondrial inner membrane threonine catabolic process biological_process glycine C-acetyltransferase activity biosynthetic process nuclear speck transferase activity transferase activity, transferring acyl groups L-threonine catabolic process to glycine pyridoxal phosphate binding uc007wse.1 uc007wse.2 uc007wse.3 uc007wse.4 
ENSMUST00000006556.11 Mpl ENSMUST00000006556.11 myeloproliferative leukemia virus oncogene, transcript variant 1 (from RefSeq NM_001122949.3) A2A9D4 A2A9D4_MOUSE ENSMUST00000006556.1 ENSMUST00000006556.10 ENSMUST00000006556.2 ENSMUST00000006556.3 ENSMUST00000006556.4 ENSMUST00000006556.5 ENSMUST00000006556.6 ENSMUST00000006556.7 ENSMUST00000006556.8 ENSMUST00000006556.9 Mpl NM_001122949 uc012djy.1 uc012djy.2 uc012djy.3 uc012djy.4 Belongs to the type I cytokine receptor family. Type 1 subfamily. neutrophil homeostasis cytokine receptor activity Golgi apparatus plasma membrane cell surface membrane integral component of membrane cytokine-mediated signaling pathway monocyte homeostasis thrombopoietin-mediated signaling pathway thrombopoietin receptor activity neuron projection neuronal cell body positive regulation of lymphocyte proliferation platelet aggregation cellular response to hypoxia positive regulation of platelet formation eosinophil homeostasis basophil homeostasis uc012djy.1 uc012djy.2 uc012djy.3 uc012djy.4 
ENSMUST00000006557.13 Elovl1 ENSMUST00000006557.13 ELOVL fatty acid elongase 1, transcript variant 2 (from RefSeq NM_019422.4) ELOV1_MOUSE ENSMUST00000006557.1 ENSMUST00000006557.10 ENSMUST00000006557.11 ENSMUST00000006557.12 ENSMUST00000006557.2 ENSMUST00000006557.3 ENSMUST00000006557.4 ENSMUST00000006557.5 ENSMUST00000006557.6 ENSMUST00000006557.7 ENSMUST00000006557.8 ENSMUST00000006557.9 Elovl1 NM_019422 Q9D1B2 Q9JLJ5 Ssc1 uc008ujz.1 uc008ujz.2 uc008ujz.3 uc008ujz.4 Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long- chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=2.3.1.199; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32728; Evidence=; Reaction=eicosanoyl-CoA + H(+) + malonyl-CoA = 3-oxodocosanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35327, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:57384, ChEBI:CHEBI:71451; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35328; Evidence=; Reaction=docosanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetracosanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36507, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:65059, ChEBI:CHEBI:73977; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36508; Evidence=; Reaction=H(+) + malonyl-CoA + tetracosanoyl-CoA = 3-oxohexacosanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36515, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:65052, ChEBI:CHEBI:73980; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36516; Evidence=; Reaction=(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA = (13Z)-3- oxodocosenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36527, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74069, ChEBI:CHEBI:74070; Evidence=; Reaction=(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA = (15Z)-3- oxotetracosenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36531, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74068, ChEBI:CHEBI:74071; Evidence=; Lipid metabolism; fatty acid biosynthesis. Interacts with LASS2, TECR and HSD17B12. Endoplasmic reticulum membrane ; Multi-pass membrane protein Expressed in a broad variety of tissues. Highly expressed in stomach, lung, kidney, skin and intestine. Moderately expressed in white adipose tissue, liver, spleen, brain, brown adipose tissue, heart and muscle. Weakly expressed in testis. The C-terminal di-lysine motif may confer endoplasmic reticulum localization. Homozygous knockout mice die within one day after birth (PubMed:23689133). Death is caused by a skin barrier deficiency and excessive water loss that are associated with impaired formation of lipid lamellae in the stratum corneum (PubMed:23689133). In the epidermis, the levels of ceramides with fatty acid chains containing more than 26 carbons are decreased, while the levels of ceramides with less than 24 carbons are increased (PubMed:23689133). Belongs to the ELO family. ELOVL1 subfamily. The substrate specificity could be slightly different compared to human ELOVL1, AC Q9BW60. No activity toward octadecanoyl-CoA, for instance, is observed in vivo (PubMed:23689133). endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process fatty acid elongase activity membrane integral component of membrane transferase activity fatty acid elongation, saturated fatty acid sphingolipid biosynthetic process integral component of endoplasmic reticulum membrane fatty acid elongation, monounsaturated fatty acid fatty acid elongation, polyunsaturated fatty acid long-chain fatty-acyl-CoA biosynthetic process very long-chain fatty acid biosynthetic process ceramide biosynthetic process establishment of skin barrier 3-oxo-arachidoyl-CoA synthase activity 3-oxo-cerotoyl-CoA synthase activity 3-oxo-lignoceronyl-CoA synthase activity uc008ujz.1 uc008ujz.2 uc008ujz.3 uc008ujz.4 
ENSMUST00000006559.14 Tpbg ENSMUST00000006559.14 trophoblast glycoprotein, transcript variant 1 (from RefSeq NM_011627.4) 5t4 ENSMUST00000006559.1 ENSMUST00000006559.10 ENSMUST00000006559.11 ENSMUST00000006559.12 ENSMUST00000006559.13 ENSMUST00000006559.2 ENSMUST00000006559.3 ENSMUST00000006559.4 ENSMUST00000006559.5 ENSMUST00000006559.6 ENSMUST00000006559.7 ENSMUST00000006559.8 ENSMUST00000006559.9 NM_011627 Q3UPI2 Q6PE98 Q8BQA4 Q9Z0L0 TPBG_MOUSE uc009qwz.1 uc009qwz.2 uc009qwz.3 uc009qwz.4 May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. Cell membrane ; Single-pass type I membrane protein Highly expressed in embryo and placenta. In adult, expressed only in brain and ovary. Not detected in kidney small intestine, heart, spleen, testis, liver, lung, thymus and stomach. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. Highly glycosylated. cytoplasm endoplasmic reticulum plasma membrane membrane integral component of membrane positive regulation of synapse assembly uc009qwz.1 uc009qwz.2 uc009qwz.3 uc009qwz.4 
ENSMUST00000006565.13 Cdc20 ENSMUST00000006565.13 cell division cycle 20 (from RefSeq NM_023223.2) CDC20_MOUSE ENSMUST00000006565.1 ENSMUST00000006565.10 ENSMUST00000006565.11 ENSMUST00000006565.12 ENSMUST00000006565.2 ENSMUST00000006565.3 ENSMUST00000006565.4 ENSMUST00000006565.5 ENSMUST00000006565.6 ENSMUST00000006565.7 ENSMUST00000006565.8 ENSMUST00000006565.9 NM_023223 Q3TGP1 Q8BPG4 Q99LK3 Q9JJ66 uc008ukc.1 uc008ukc.2 uc008ukc.3 uc008ukc.4 Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (PubMed:34298015). Protein modification; protein ubiquitination. Component of a complex with CDC20, CDC27, SPATC1 and TUBG1 (PubMed:15280373). Interacts with NEUROD2 (PubMed:19900895). Interacts with dimeric MAD2L1 in its closed conformation form (By similarity). Interacts with BUB1B (By similarity). The phosphorylated form interacts with APC/C (By similarity). Interacts with NINL (By similarity). May interact with MAD2L2 (By similarity). Interacts with CDK5RAP2 (By similarity). Interacts with SIRT2 (PubMed:22014574). Interacts with isoform 1 of NEK2 (By similarity). Interacts with HSF1 (via phosphorylated form); this interaction occurs in mitosis in a MAD2L1- dependent manner and prevents PLK1-stimulated degradation of HSF1 by blocking the recruitment of the SCF(BTRC) ubiquitin ligase complex (By similarity). Interacts (via the N-terminal substrate-binding domain) with FBXO5 (PubMed:15526037). Interacts with CCNF (By similarity). Q9JJ66; Q8CDI2: Fbxo43; NbExp=2; IntAct=EBI-2551389, EBI-8060482; Q9JJ66; Q8VDQ8: Sirt2; NbExp=2; IntAct=EBI-2551389, EBI-911012; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle pole Acetylated. Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C). Phosphorylated during mitosis (By similarity). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161 (By similarity). Phosphorylated by NEK2 (By similarity). Dephosphorylated by CTDP1. Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex (By similarity). Belongs to the WD repeat CDC20/Fizzy family. spindle pole protein binding nucleus nucleoplasm anaphase-promoting complex cytoplasm centrosome microtubule organizing center cytosol cytoskeleton cell cycle mitotic sister chromatid cohesion nervous system development protein C-terminus binding positive regulation of cell proliferation anaphase-promoting complex binding protein ubiquitination enzyme binding cell differentiation anaphase-promoting complex-dependent catabolic process positive regulation of synaptic plasticity macromolecular complex regulation of meiotic nuclear division histone deacetylase binding perinuclear region of cytoplasm regulation of dendrite development cell division positive regulation of synapse maturation mitotic spindle assembly ubiquitin-protein transferase activator activity positive regulation of ubiquitin protein ligase activity uc008ukc.1 uc008ukc.2 uc008ukc.3 uc008ukc.4 
ENSMUST00000006578.10 Nectin4 ENSMUST00000006578.10 nectin cell adhesion molecule 4, transcript variant 1 (from RefSeq NM_027893.3) ENSMUST00000006578.1 ENSMUST00000006578.2 ENSMUST00000006578.3 ENSMUST00000006578.4 ENSMUST00000006578.5 ENSMUST00000006578.6 ENSMUST00000006578.7 ENSMUST00000006578.8 ENSMUST00000006578.9 Lnir NECT4_MOUSE NM_027893 Nectin4 Prr4 Pvrl4 Q3U318 Q8CED8 Q8R007 Q9DBP8 uc007dof.1 uc007dof.2 uc007dof.3 uc007dof.4 Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Self-associates. Interacts via its Ig-like V-type domain with NECTIN1 Ig-like V-type domain. Interacts via its C-terminus with AFDN (By similarity). Cell membrane ; Single-pass type I membrane protein Cell junction, adherens junction Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R007-1; Sequence=Displayed; Name=2; IsoId=Q8R007-2; Sequence=VSP_027336; Expressed in brain, lung, testis and embryo. Detected at embryonic days 11, 15 and 17. Belongs to the nectin family. Sequence=BAE32972.1; Type=Erroneous initiation; Evidence=; plasma membrane adherens junction cell-cell adherens junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules membrane integral component of membrane cell junction signaling receptor activity identical protein binding protein homodimerization activity viral entry into host cell cell adhesion molecule binding cell-cell adhesion uc007dof.1 uc007dof.2 uc007dof.3 uc007dof.4 
ENSMUST00000006587.7 Peds1 ENSMUST00000006587.7 plasmanylethanolamine desaturase 1 (from RefSeq NM_145538.2) ENSMUST00000006587.1 ENSMUST00000006587.2 ENSMUST00000006587.3 ENSMUST00000006587.4 ENSMUST00000006587.5 ENSMUST00000006587.6 NM_145538 PDES1_MOUSE PEDS1 Pdes Q99LQ7 Tmem189 uc008oad.1 uc008oad.2 uc008oad.3 Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane. Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms. Reaction=1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3- phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-O- (1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)- [cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:22956, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:75028, ChEBI:CHEBI:77290; EC=1.14.19.77; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22957; Evidence=; Reaction=a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z-hexadecenyl)-2-acyl- sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:61960, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:145181, ChEBI:CHEBI:145186; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61961; Evidence=; Reaction=a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z-octadecenyl)-2-acyl- sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:61964, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:145182, ChEBI:CHEBI:145187; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61965; Evidence=; Reaction=a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z,9Z- octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)- [cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:61968, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:145183, ChEBI:CHEBI:145188; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61969; Evidence=; Lipid metabolism; fatty acid metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Histidine box-1 and -2 together with other histidine residues are essential for catalytic activity. Body weight is reduced in homozygous deficient male and female. Deficient mice lack plasmanylethanolamine desaturase activity and have dramatically lowered plasmalogen levels in their tissues. Belongs to the fatty acid desaturase CarF family. endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane uc008oad.1 uc008oad.2 uc008oad.3 
ENSMUST00000006611.9 Srm ENSMUST00000006611.9 spermidine synthase (from RefSeq NM_009272.4) ENSMUST00000006611.1 ENSMUST00000006611.2 ENSMUST00000006611.3 ENSMUST00000006611.4 ENSMUST00000006611.5 ENSMUST00000006611.6 ENSMUST00000006611.7 ENSMUST00000006611.8 NM_009272 Q64674 SPEE_MOUSE uc008vuw.1 uc008vuw.2 uc008vuw.3 Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3- diaminopropane. Has extremely low activity towards spermidine (By similarity). Reaction=putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine; Xref=Rhea:RHEA:12721, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:57443, ChEBI:CHEBI:57834, ChEBI:CHEBI:326268; EC=2.5.1.16; The activity is thought to be regulated mainly by the availability of decarboxylated S-adenosylmethionine. Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. Homodimer or homotetramer. Belongs to the spermidine/spermine synthase family. catalytic activity spermidine synthase activity polyamine metabolic process polyamine biosynthetic process spermidine biosynthetic process transferase activity identical protein binding protein homodimerization activity cellular response to leukemia inhibitory factor uc008vuw.1 uc008vuw.2 uc008vuw.3 
ENSMUST00000006614.3 Epha2 ENSMUST00000006614.3 Eph receptor A2 (from RefSeq NM_010139.3) ENSMUST00000006614.1 ENSMUST00000006614.2 EPHA2_MOUSE Eck Myk2 NM_010139 Q03145 Q3UNI2 Q60633 Q62212 Sek2 uc008voc.1 uc008voc.2 uc008voc.3 uc008voc.4 Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin- A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells (PubMed:29749928). Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 signaling pathway. May also participate in UV radiation- induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence= Homodimer. Interacts with INPPL1; regulates activated EPHA2 endocytosis and degradation (PubMed:29749928). Interacts (inactivated form) with PTK2/FAK1 and interacts (EFNA1 ligand-activated form) with PTPN11; regulates integrin-mediated adhesion. Interacts with ARHGEF16, DOCK4 and ELMO2; mediates ligand-independent activation of RAC1 which stimulates cell migration. Interacts with CLDN4; phosphorylates CLDN4 and may regulate tight junctions. Interacts with ACP1. Interacts with CEMIP. Interacts with NCK1; may regulate EPHA2 activity in cell migration and adhesion. Interacts with SLA. Interacts (phosphorylated form) with VAV2, VAV3 and PI3-kinase p85 subunit (PIK3R1, PIK3R2 or PIK3R3); critical for the EFNA1-induced activation of RAC1 which stimulates cell migration. Interacts with ANKS1A. Interacts with TIMD4 (By similarity). Q03145; Q03137: Epha4; NbExp=3; IntAct=EBI-529701, EBI-1539152; Cell membrane ; Single-pass type I membrane protein Cell projection, ruffle membrane ; Single-pass type I membrane protein Cell projection, lamellipodium membrane ; Single-pass type I membrane protein Cell junction, focal adhesion Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells. Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells. Expressed in the lung, intestine and liver (PubMed:11287184). Expressed in myogenic progenitor cells (PubMed:27446912). First detected in gastrulation stage embryos (6.5- 7.5 dpc) in ectodermal cells adjacent to the distal region of the primitive streak. By the neural plate stage (approximately 7.5 dpc), EPHA2 expression becomes restricted to the extreme distal end or node of the primitive streak. After the beginning of somitogenesis (approximately 8.0 dpc), expression persists in the node as this structure regresses toward the caudal end of the embryo. In addition, beginning at the mid head fold stage (approximately 7.75 dpc), we observe that EPHA2 exhibits a dynamic and spatially restricted expression pattern in the prospective hindbrain region. EPHA2 transcripts are initially detected in a 5-cell wide strip of mesodermal cells underlying prospective rhombomere 4 (R4). Subsequently at the beginning of somitogenesis, expression is observed in prospective R4. At the 4-8-somite stage, EPHA2 transcripts are observed in R4, mesenchymal cells underlying R4, and surface ectoderm in the vicinity of the developing second branchial arch. By the 10-somite stage, expression in these cells is down-regulated. Additionally, at the 5-8- somite stage, EPHA2 transcripts are detected initially in the lateral mesenchyme immediately underlying the surface ectoderm adjacent to R5 and R6, and subsequently in surface ectoderm overlying the developing third branchial arch. In myogenic progenitor cells, expressed during the acquisition of muscle stem cell properties, from 18.5 dpc to adulthood (PubMed:27446912). Autophosphorylates. Phosphorylated at Ser-898 by PKB; serum- induced phosphorylation which targets EPHA2 to the cell leading edge and stimulates cell migration. Phosphorylation by PKB is inhibited by EFNA1-activated EPHA2 which regulates PKB activity via a reciprocal regulatory loop. Phosphorylated on tyrosine upon binding and activation by EFNA1. Phosphorylated residues Tyr-589 and Tyr-595 are required for binding VAV2 and VAV3 while phosphorylated residues Tyr-736 and Tyr-931 are required for binding PI3-kinase p85 subunit (PIK3R1, PIK3R2 or PIK3R3). These phosphorylated residues are critical for recruitment of VAV2 and VAV3 and PI3-kinase p85 subunit which transduce downstream signaling to activate RAC1 GTPase and cell migration. Dephosphorylation of Tyr-931 by PTPRF prevents the interaction of EPHA2 with NCK1. Phosphorylated at Ser-898 in response to TNF by RPS6KA1 and RPS6KA3; RPS6KA-EPHA2 signaling pathway controls cell migration. Phosphorylated at Ser-898 by PKA; blocks cell retraction induced by EPHA2 kinase activity. Dephosphorylated by ACP1. Ubiquitinated by CHIP/STUB1. Ubiquitination is regulated by the HSP90 chaperone and regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation. Mice are viable, fertile but exhibit aberrant development of tail vertebra and susceptibility to carcinogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. nucleotide binding skeletal system development angiogenesis blood vessel development vasculogenesis osteoblast differentiation negative regulation of cytokine production blood vessel endothelial cell proliferation involved in sprouting angiogenesis protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity transmembrane-ephrin receptor activity protein binding ATP binding plasma membrane integral component of plasma membrane focal adhesion protein phosphorylation apoptotic process inflammatory response cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway axon guidance intrinsic apoptotic signaling pathway in response to DNA damage cell surface regulation of lamellipodium assembly notochord formation membrane integral component of membrane kinase activity phosphorylation cell migration negative regulation of angiogenesis transferase activity peptidyl-tyrosine phosphorylation neural tube development lamellipodium cell junction cell differentiation neuron differentiation keratinocyte differentiation osteoclast differentiation leading edge membrane lamellipodium membrane ruffle membrane negative regulation of chemokine production mammary gland epithelial cell proliferation regulation of cell adhesion mediated by integrin post-anal tail morphogenesis cell projection neuron projection receptor complex protein kinase B signaling regulation of blood vessel endothelial cell migration regulation of angiogenesis cAMP metabolic process bone remodeling ephrin receptor signaling pathway axial mesoderm formation blood vessel morphogenesis notochord morphogenesis cell motility defense response to Gram-positive bacterium negative regulation of protein kinase B signaling notochord cell development cell chemotaxis branching involved in mammary gland duct morphogenesis occluding junction lens fiber cell morphogenesis regulation of ERK1 and ERK2 cascade response to growth factor protein localization to plasma membrane activation of GTPase activity negative regulation of lymphangiogenesis positive regulation of protein localization to plasma membrane positive regulation of bicellular tight junction assembly pericyte cell differentiation uc008voc.1 uc008voc.2 uc008voc.3 uc008voc.4 
ENSMUST00000006618.9 Arhgef19 ENSMUST00000006618.9 Rho guanine nucleotide exchange factor 19, transcript variant 2 (from RefSeq NM_172520.3) ARHGJ_MOUSE ENSMUST00000006618.1 ENSMUST00000006618.2 ENSMUST00000006618.3 ENSMUST00000006618.4 ENSMUST00000006618.5 ENSMUST00000006618.6 ENSMUST00000006618.7 ENSMUST00000006618.8 NM_172520 Q6PAC2 Q8BWA8 Wgef uc008vob.1 uc008vob.2 uc008vob.3 Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. Highly expressed in intestine, and at lower levels in liver, heart and kidney. guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity regulation of actin cytoskeleton organization regulation of Rho protein signal transduction wound healing positive regulation of GTPase activity uc008vob.1 uc008vob.2 uc008vob.3 
ENSMUST00000006625.8 Rbm14 ENSMUST00000006625.8 RNA binding motif protein 14 (from RefSeq NM_019869.3) ENSMUST00000006625.1 ENSMUST00000006625.2 ENSMUST00000006625.3 ENSMUST00000006625.4 ENSMUST00000006625.5 ENSMUST00000006625.6 ENSMUST00000006625.7 NM_019869 Q3TJB6 Q8C2Q3 Q91Z21 Q9DBI6 RBM14_MOUSE uc008gaz.1 uc008gaz.2 uc008gaz.3 uc008gaz.4 May function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1 (By similarity). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity (PubMed:25385835). Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Interacts with NCOA6, CITED1 and XRCC5/KU86. Interacts with SS18. Interacts with STIL and interferes with its interaction with CENPJ. Interacts with gamma-tubulin. Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA. Nucleus Nucleus, nucleolus Cytoplasm Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Cytoplasmic localization is crucial for its function in suppressing the formation of aberrant centriolar protein complexes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C2Q3-1; Sequence=Displayed; Name=2; IsoId=Q8C2Q3-2; Sequence=VSP_015080; activation of innate immune response immune system process nucleic acid binding RNA binding nucleus transcription factor complex nucleolus cytoplasm histone deacetylation nuclear speck ligand-dependent nuclear receptor transcription coactivator activity innate immune response positive regulation of transcription from RNA polymerase II promoter negative regulation of centriole replication SMAD protein signal transduction centriole assembly uc008gaz.1 uc008gaz.2 uc008gaz.3 uc008gaz.4 
ENSMUST00000006626.5 Actn3 ENSMUST00000006626.5 actinin alpha 3 (from RefSeq NM_013456.2) ACTN3_MOUSE ENSMUST00000006626.1 ENSMUST00000006626.2 ENSMUST00000006626.3 ENSMUST00000006626.4 NM_013456 O88990 Q14DS8 uc008gbf.1 uc008gbf.2 uc008gbf.3 uc008gbf.4 uc008gbf.5 This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF093775.1, BC111890.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). Homodimer; antiparallel. Also forms heterodimers with ACTN2. Interacts with MYOZ1 (By similarity). Belongs to the alpha-actinin family. actin binding calcium ion binding protein binding striated muscle thin filament brush border muscle contraction regulation of the force of skeletal muscle contraction skeletal muscle atrophy transition between fast and slow fiber response to denervation involved in regulation of muscle adaptation sarcomere Z disc protein binding, bridging positive regulation of fast-twitch skeletal muscle fiber contraction protein homodimerization activity negative regulation of glycolytic process metal ion binding positive regulation of skeletal muscle tissue growth positive regulation of skeletal muscle fiber development actin filament binding bone morphogenesis negative regulation of calcineurin-NFAT signaling cascade regulation of muscle system process negative regulation of oxidative phosphorylation positive regulation of bone mineralization involved in bone maturation negative regulation of relaxation of muscle regulation of aerobic respiration positive regulation of glucose catabolic process to lactate via pyruvate osteoblast differentiation uc008gbf.1 uc008gbf.2 uc008gbf.3 uc008gbf.4 uc008gbf.5 
ENSMUST00000006629.14 Sptbn1 ENSMUST00000006629.14 Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. (from UniProt Q62261) A2AFU1 ENSMUST00000006629.1 ENSMUST00000006629.10 ENSMUST00000006629.11 ENSMUST00000006629.12 ENSMUST00000006629.13 ENSMUST00000006629.2 ENSMUST00000006629.3 ENSMUST00000006629.4 ENSMUST00000006629.5 ENSMUST00000006629.6 ENSMUST00000006629.7 ENSMUST00000006629.8 ENSMUST00000006629.9 Elf M74773 Q3TEM7 Q5SQL8 Q5SQL9 Q62261 Q9QWJ7 SPTB2_MOUSE Spnb-2 Spnb2 Sptb2 uc007ihs.1 uc007ihs.2 uc007ihs.3 Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. Interacts with ANK2 (PubMed:15262991). Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers (By similarity). Interacts with CAMSAP1 (By similarity). Can form heterodimers with SPTAN1. Cytoplasm, cytoskeleton Endomembrane system Cytoplasm, myofibril, sarcomere, M line Cytoplasm, cytosol Cell membrane Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes. [Isoform 2]: Cytoplasm Cell membrane ; Peripheral membrane protein; Cytoplasmic side. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q62261-1; Sequence=Displayed; Name=2; Synonyms=Elf3; IsoId=Q62261-2; Sequence=VSP_026057, VSP_026058, VSP_026059; Isoform 2 is present in brain, heart, kidney and liver (at protein level). Isoform 2 is expressed in brain, heart and liver throughout embryonic development. Isoform 1 is mainly expressed in neonatal developing ventricular cardiomyocytes. Belongs to the spectrin family. mitotic cytokinesis actin binding structural constituent of cytoskeleton protein binding calmodulin binding phospholipid binding nucleus nucleolus cytoplasm cytoskeleton plasma membrane plasma membrane organization cytoskeleton organization common-partner SMAD protein phosphorylation spectrin endomembrane system postsynaptic density membrane ankyrin binding axolemma cortical cytoskeleton M band cuticular plate macromolecular complex Golgi to plasma membrane protein transport macromolecular complex binding GTPase binding actin filament capping regulation of SMAD protein import into nucleus membrane assembly protein localization to plasma membrane postsynapse glutamatergic synapse positive regulation of interleukin-2 secretion regulation of protein localization to plasma membrane positive regulation of protein localization to plasma membrane uc007ihs.1 uc007ihs.2 uc007ihs.3 
ENSMUST00000006632.8 Zdhhc24 ENSMUST00000006632.8 zinc finger, DHHC domain containing 24, transcript variant 1 (from RefSeq NM_027476.3) ENSMUST00000006632.1 ENSMUST00000006632.2 ENSMUST00000006632.3 ENSMUST00000006632.4 ENSMUST00000006632.5 ENSMUST00000006632.6 ENSMUST00000006632.7 NM_027476 Q3TAY4 Q3TDF1 Q3TF09 Q6IR37 Q9CS66 ZDH24_MOUSE Zdhhc24 uc008gbh.1 uc008gbh.2 uc008gbh.3 uc008gbh.4 Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Membrane ; Multi-pass membrane protein The DHHC domain is required for palmitoyltransferase activity. Belongs to the DHHC palmitoyltransferase family. Sequence=BAB30905.2; Type=Frameshift; Evidence=; endoplasmic reticulum Golgi apparatus protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein-cysteine S-palmitoyltransferase activity uc008gbh.1 uc008gbh.2 uc008gbh.3 uc008gbh.4 
ENSMUST00000006638.8 Slc34a3 ENSMUST00000006638.8 solute carrier family 34 (sodium phosphate), member 3, transcript variant 1 (from RefSeq NM_080854.3) ENSMUST00000006638.1 ENSMUST00000006638.2 ENSMUST00000006638.3 ENSMUST00000006638.4 ENSMUST00000006638.5 ENSMUST00000006638.6 ENSMUST00000006638.7 NM_080854 NPT2C_MOUSE Npt2c Q05AC3 Q80SU6 uc008iqt.1 uc008iqt.2 uc008iqt.3 uc008iqt.4 uc008iqt.5 Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:12690469, PubMed:16113079). The cotransport has a Na(+):Pi stoichiometry of 2:1 and is electroneutral (PubMed:16113079). Reaction=2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in); Xref=Rhea:RHEA:71259, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71260; Evidence=; Kinetic parameters: KM=200 uM for phosphate ; pH dependence: Optimum pH is 7.5. ; Apical cell membrane ; Multi-pass membrane protein Note=Localized at the brush border membrane in the kidney. Expressed only in the kidney. Belongs to the SLC34A transporter family. sodium:phosphate symporter activity plasma membrane brush border ion transport sodium ion transport phosphate ion transport symporter activity sodium-dependent phosphate transmembrane transporter activity membrane integral component of membrane apical plasma membrane cellular phosphate ion homeostasis cytoplasmic vesicle brush border membrane vesicle sodium ion transmembrane transport sodium-dependent phosphate transport transmembrane transport uc008iqt.1 uc008iqt.2 uc008iqt.3 uc008iqt.4 uc008iqt.5 
ENSMUST00000006646.15 Nsmf ENSMUST00000006646.15 NMDA receptor synaptonuclear signaling and neuronal migration factor, transcript variant 15 (from RefSeq NR_185326.1) A2AJ93 A2AJ94 ENSMUST00000006646.1 ENSMUST00000006646.10 ENSMUST00000006646.11 ENSMUST00000006646.12 ENSMUST00000006646.13 ENSMUST00000006646.14 ENSMUST00000006646.2 ENSMUST00000006646.3 ENSMUST00000006646.4 ENSMUST00000006646.5 ENSMUST00000006646.6 ENSMUST00000006646.7 ENSMUST00000006646.8 ENSMUST00000006646.9 Jac NR_185326 NSMF_MOUSE Nelf Q8BPT0 Q8C9R5 Q99NF2 Q9DBF4 Q9ERZ1 uc008iqc.1 uc008iqc.2 uc008iqc.3 Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. Interacts with KPNA1; the interaction occurs in a calcium- independent manner after synaptic NMDA receptor stimulation and is required for nuclear import of NSMF but is competed by CABP1. Interacts (via the central NLS-containing motif region) with CABP1 (via EF-hands 1 and 2); the interaction occurs in a calcium-dependent manner after synaptic NMDA receptor stimulation and prevents the nuclear import of NSMF. Cannot be competed by calmodulin (By similarity). Q99NF2-1; O88751-1: Cabp1; Xeno; NbExp=2; IntAct=EBI-15688721, EBI-15688755; Nucleus. Nucleus envelope Nucleus membrane Nucleus matrix Cytoplasm. Cytoplasm, cell cortex Cytoplasm, cytoskeleton Cell membrane; Peripheral membrane protein. Cell projection, dendrite Synapse Synapse, synaptosome Postsynaptic density Membrane Note=Found on the outside of the luteinizing-hormone- releasing hormone (LHRH) cell membrane and axons projecting from the olfactory pit and epithelium. Associates with transcriptionally active chromatin regions. Detected at the nuclear membranes of CA1 neurons. Cortical cytoskeleton. Localized in proximal apical dendrites. Colocalizes with CABP1 in dendrites and dendritic spines. Myristoylation is a prerequisite for extranuclear localization. Translocates from dendrites to the nucleus during NMDA receptor- dependent long-term potentiation (LTP) induction of synaptic transmission at Schaffer collateral/CA1 synapses of hippocampal primary neurons and in an importin-dependent manner (By similarity). Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q99NF2-1; Sequence=Displayed; Name=2; IsoId=Q99NF2-2; Sequence=VSP_014767; Name=3; IsoId=Q99NF2-3; Sequence=VSP_014768; Name=4; IsoId=Q99NF2-4; Sequence=VSP_014764, VSP_014767, VSP_014769; Name=5; IsoId=Q99NF2-5; Sequence=VSP_014765, VSP_014766; Preferentially expressed in immature migratory, in comparison to postmigrating, gonadotropin-releasing hormone (GnRH) neuronal cell lines (at protein level). Expressed in adult brain and liver. In the brain, expressed in the primary pituitary gland, cortex, hippocampus, olfactory bulb and thalamus. At 14.5 dpc embryo found at high levels within the forebrain, olfactory epithelium and olfactory pit. At 12.5 dpc embryo detected on olfactory axons including olfactory pathway on which the LHRH neurons move. From 11.5 dpc to 17.5 dpc embryos expressed in LHRH (luteinizing hormone-releasing hormone) neurons as they migrate from the olfactory pit into the developing forebrain. Up-regulated by gonadotropin releasing hormone (GnRH). Proteolytically processed after NMDA receptor activation. Cleaved in a calcium-dependent and calpain-sensitive manner. Calpain cleavage is essential for the translocation process from dendrites to the nucleus (By similarity). Transport from dendrites to the nucleus is induced by NMDA receptor activation and results in a rapid stripping of synaptic contacts and a reduction of dendritic complexity (By similarity). KIF5C associates to its 3'-UTR mRNA in granules along dendritic shafts, suggesting that this protein may regulate its dendritic trafficking and local translation at postsynaptic sites. Belongs to the NSMF family. protein binding nucleus nuclear envelope nucleoplasm nuclear euchromatin cytoplasm cytoskeleton plasma membrane cell cortex postsynaptic density membrane nuclear matrix cell junction dendrite cortical cytoskeleton nuclear membrane positive regulation of protein dephosphorylation cell projection neuron projection dendritic spine perikaryon regulation of neuron apoptotic process synapse postsynaptic membrane regulation of neuronal synaptic plasticity calcium-dependent protein binding regulation of dendrite morphogenesis cellular response to amino acid stimulus cellular response to electrical stimulus cellular response to gonadotropin stimulus apical dendrite postsynapse glutamatergic synapse postsynapse to nucleus signaling pathway regulation of neuron migration positive regulation of neuron migration uc008iqc.1 uc008iqc.2 uc008iqc.3 
ENSMUST00000006659.8 Prl7a1 ENSMUST00000006659.8 prolactin family 7, subfamily a, member 1, transcript variant 2 (from RefSeq NM_008930.2) ENSMUST00000006659.1 ENSMUST00000006659.2 ENSMUST00000006659.3 ENSMUST00000006659.4 ENSMUST00000006659.5 ENSMUST00000006659.6 ENSMUST00000006659.7 NM_008930 O35334 O54830 PR7A1_MOUSE Prlpe Prlpg Q80X21 uc007pxy.1 uc007pxy.2 uc007pxy.3 uc007pxy.4 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O54830-1; Sequence=Displayed; Name=2; IsoId=O54830-2; Sequence=VSP_016678; Expressed specifically in the placenta. Detected only in the trophoblast giant cells. Highest expression at mid-pregnancy. Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pxy.1 uc007pxy.2 uc007pxy.3 uc007pxy.4 
ENSMUST00000006660.7 Prl7a2 ENSMUST00000006660.7 prolactin family 7, subfamily a, member 2 (from RefSeq NM_011168.4) ENSMUST00000006660.1 ENSMUST00000006660.2 ENSMUST00000006660.3 ENSMUST00000006660.4 ENSMUST00000006660.5 ENSMUST00000006660.6 NM_011168 O54831 PR7A2_MOUSE Prlpf uc007pya.1 uc007pya.2 Secreted Expression restricted to the placental tissue. Expressed only in the spongiotrophoblasts. Not detected until later in gestation. Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pya.1 uc007pya.2 
ENSMUST00000006662.4 Prl8a9 ENSMUST00000006662.4 prolactin family8, subfamily a, member 9, transcript variant 1 (from RefSeq NM_023332.4) ENSMUST00000006662.1 ENSMUST00000006662.2 ENSMUST00000006662.3 NM_023332 PR8A9_MOUSE Prlpc2 Q9CQ58 uc007pxu.1 uc007pxu.2 uc007pxu.3 uc007pxu.4 Secreted Detected only in placenta. Localized to spongiotrophoblasts and trophoblast giant cells of the placenta. First detected at 11.5 dpc and expressed continually throughout development, its expression level fluctuated during gestation. Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pxu.1 uc007pxu.2 uc007pxu.3 uc007pxu.4 
ENSMUST00000006664.8 Prl8a1 ENSMUST00000006664.8 prolactin family 8, subfamily a, member 1 (from RefSeq NM_028477.2) ENSMUST00000006664.1 ENSMUST00000006664.2 ENSMUST00000006664.3 ENSMUST00000006664.4 ENSMUST00000006664.5 ENSMUST00000006664.6 ENSMUST00000006664.7 Ghd16 NM_028477 Plpcd Prl8a1 Prlpc4 Q9DAV8 Q9DAV8_MOUSE uc007pxv.1 uc007pxv.2 Secreted Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation membrane integral component of membrane mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pxv.1 uc007pxv.2 
ENSMUST00000006669.6 Pdk1 ENSMUST00000006669.6 pyruvate dehydrogenase kinase, isoenzyme 1, transcript variant 1 (from RefSeq NM_172665.5) ENSMUST00000006669.1 ENSMUST00000006669.2 ENSMUST00000006669.3 ENSMUST00000006669.4 ENSMUST00000006669.5 NM_172665 PDK1_MOUSE Q3U5E5 Q8BFP9 uc008kbj.1 uc008kbj.2 uc008kbj.3 uc008kbj.4 Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress (By similarity). Reaction=ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]; Xref=Rhea:RHEA:23052, Rhea:RHEA-COMP:13689, Rhea:RHEA-COMP:13690, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.2; Homodimer, and heterodimer with PDK2. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3) (By similarity). Mitochondrion matrix Up-regulated by glucose and palmitate. Up- regulated via the HIF1A signaling pathway in response to hypoxia. Phosphorylated by constitutively activated ABL1, FGFR1, FLT3 and JAK2 (in vitro), and this may also occur in cancer cells that express constitutively activated ABL1, FGFR1, FLT3 and JAK2. Phosphorylation at Tyr-241 and Tyr-242 strongly increases kinase activity, while phosphorylation at Tyr-136 has a lesser effect (By similarity). Belongs to the PDK/BCKDK protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity pyruvate dehydrogenase (acetyl-transferring) kinase activity ATP binding nucleus nucleolus mitochondrion mitochondrial matrix plasma membrane mitochondrial pyruvate dehydrogenase complex carbohydrate metabolic process glucose metabolic process protein phosphorylation cell surface receptor signaling pathway cell proliferation intrinsic apoptotic signaling pathway in response to oxidative stress regulation of acetyl-CoA biosynthetic process from pyruvate regulation of glucose metabolic process kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction protein homodimerization activity macromolecular complex binding pyruvate dehydrogenase complex protein heterodimerization activity hypoxia-inducible factor-1alpha signaling pathway uc008kbj.1 uc008kbj.2 uc008kbj.3 uc008kbj.4 
ENSMUST00000006679.15 Prtn3 ENSMUST00000006679.15 proteinase 3 (from RefSeq NM_011178.3) A0A0R4IZY6 A0A0R4IZY6_MOUSE ENSMUST00000006679.1 ENSMUST00000006679.10 ENSMUST00000006679.11 ENSMUST00000006679.12 ENSMUST00000006679.13 ENSMUST00000006679.14 ENSMUST00000006679.2 ENSMUST00000006679.3 ENSMUST00000006679.4 ENSMUST00000006679.5 ENSMUST00000006679.6 ENSMUST00000006679.7 ENSMUST00000006679.8 ENSMUST00000006679.9 NM_011178 Prtn3 uc007gah.1 uc007gah.2 uc007gah.3 uc007gah.4 serine-type endopeptidase activity receptor binding cytosol plasma membrane proteolysis membrane protein ectodomain proteolysis peptidase activity serine-type peptidase activity hydrolase activity enzyme binding azurophil granule lumen positive regulation of GTPase activity plasma membrane raft cell-cell junction maintenance negative regulation of phagocytosis neutrophil extravasation mature conventional dendritic cell differentiation uc007gah.1 uc007gah.2 uc007gah.3 uc007gah.4 
ENSMUST00000006687.5 Orm3 ENSMUST00000006687.5 orosomucoid 3, transcript variant 5 (from RefSeq NR_166740.1) ENSMUST00000006687.1 ENSMUST00000006687.2 ENSMUST00000006687.3 ENSMUST00000006687.4 J3JRU4 J3JRU4_MOUSE NR_166740 Orm3 uc008tfz.1 uc008tfz.2 Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction. Secreted Belongs to the calycin superfamily. Lipocalin family. regulation of immune system process extracellular region extracellular space uc008tfz.1 uc008tfz.2 
ENSMUST00000006692.6 Mvd ENSMUST00000006692.6 mevalonate (diphospho) decarboxylase, transcript variant 1 (from RefSeq NM_138656.2) ENSMUST00000006692.1 ENSMUST00000006692.2 ENSMUST00000006692.3 ENSMUST00000006692.4 ENSMUST00000006692.5 MVD1_MOUSE NM_138656 Q3TCD8 Q8BTM4 Q922D7 Q99JF5 uc009nss.1 uc009nss.2 uc009nss.3 uc009nss.4 Catalyzes the ATP dependent decarboxylation of (R)-5- diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. Reaction=(R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate; Xref=Rhea:RHEA:23732, ChEBI:CHEBI:16526, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57557, ChEBI:CHEBI:128769, ChEBI:CHEBI:456216; EC=4.1.1.33; Evidence=; Steroid biosynthesis; cholesterol biosynthesis. Homodimer. Cytoplasm Belongs to the diphosphomevalonate decarboxylase family. Was originally thought to be located in the peroxisome (By similarity). However, was later shown to be cytosolic (PubMed:12736493). nucleotide binding diphosphomevalonate decarboxylase activity ATP binding peroxisome peroxisomal matrix cytosol lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process steroid metabolic process cholesterol metabolic process positive regulation of cell proliferation isoprenoid biosynthetic process sterol biosynthetic process lyase activity carboxy-lyase activity isopentenyl diphosphate biosynthetic process, mevalonate pathway Hsp70 protein binding protein homodimerization activity uc009nss.1 uc009nss.2 uc009nss.3 uc009nss.4 
ENSMUST00000006697.17 Itih3 ENSMUST00000006697.17 inter-alpha trypsin inhibitor, heavy chain 3, transcript variant 1 (from RefSeq NM_008407.3) E9QME9 ENSMUST00000006697.1 ENSMUST00000006697.10 ENSMUST00000006697.11 ENSMUST00000006697.12 ENSMUST00000006697.13 ENSMUST00000006697.14 ENSMUST00000006697.15 ENSMUST00000006697.16 ENSMUST00000006697.2 ENSMUST00000006697.3 ENSMUST00000006697.4 ENSMUST00000006697.5 ENSMUST00000006697.6 ENSMUST00000006697.7 ENSMUST00000006697.8 ENSMUST00000006697.9 ITIH3_MOUSE NM_008407 Q61704 Q91WG9 uc033goz.1 uc033goz.2 uc033goz.3 uc033goz.4 This gene encodes one of the heavy subunits of inter alpha trypsin inhibitor that functions as a protease inhibitor circulating in the plasma. The encoded protein undergoes proteolytic processing to generate a mature glycoprotein that is linked to the other subunits via an ester bond between the C-terminal aspartic acid residue and the N-acetyl galactosamine residue of chondroitin sulfate. This gene is located in a cluster of related inter alpha trypsin inhibitor genes on chromosome 14. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015276.1, X70393.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Pre-alpha-inhibitor (P-alpha-I) is composed of ITIH3/HC3 and bikunin. Secreted. Expressed in both liver and brain. Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage. Belongs to the ITIH family. Sequence=AAH15276.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAA49843.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; serine-type endopeptidase inhibitor activity extracellular region negative regulation of peptidase activity negative regulation of endopeptidase activity hyaluronan metabolic process peptidase inhibitor activity uc033goz.1 uc033goz.2 uc033goz.3 uc033goz.4 
ENSMUST00000006701.8 Stimate ENSMUST00000006701.8 STIM activating enhancer (from RefSeq NM_028839.4) ENSMUST00000006701.1 ENSMUST00000006701.2 ENSMUST00000006701.3 ENSMUST00000006701.4 ENSMUST00000006701.5 ENSMUST00000006701.6 ENSMUST00000006701.7 NM_028839 Q3U2J0 Q3UF25 Q8C691 Q8R3U0 Q9D7D4 Q9D8S1 STIMA_MOUSE Stimate Tmem110 uc007svt.1 uc007svt.2 uc007svt.3 uc007svt.4 Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions. Homooligomer. Interacts with STIM1. Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Colocalizes with STIM1 at ER- plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells. May translocate to ER- PM junctions in a STIM1-dependent manner in store-depleted cells. Widely expressed. The GXXXG motif may mediate oligomerization. The C-terminus is necessary for its localization at ER-plasma membrane (ER-PM) junctions as well as for the store-dependent rearrangement of ER-PM junctions. Belongs to the STIMATE family. calcium channel regulator activity endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane activation of store-operated calcium channel activity cortical endoplasmic reticulum calcium-mediated signaling using intracellular calcium source positive regulation of calcineurin-NFAT signaling cascade uc007svt.1 uc007svt.2 uc007svt.3 uc007svt.4 
ENSMUST00000006716.8 Wnt6 ENSMUST00000006716.8 wingless-type MMTV integration site family, member 6 (from RefSeq NM_009526.3) ENSMUST00000006716.1 ENSMUST00000006716.2 ENSMUST00000006716.3 ENSMUST00000006716.4 ENSMUST00000006716.5 ENSMUST00000006716.6 ENSMUST00000006716.7 NM_009526 P22727 Q80ZM9 WNT6_MOUSE Wnt-6 uc007bne.1 uc007bne.2 uc007bne.3 Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Interacts with PORCN. Secreted, extracellular space, extracellular matrix. Detected in ileum, colon and stomach (at protein level). Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. Belongs to the Wnt family. branching involved in ureteric bud morphogenesis receptor binding frizzled binding extracellular region extracellular space endoplasmic reticulum lumen signal transduction cell-cell signaling multicellular organism development axis specification animal organ morphogenesis cell surface positive regulation of gene expression Wnt signaling pathway neuron differentiation extracellular matrix odontogenesis of dentin-containing tooth cell fate commitment positive regulation of transcription, DNA-templated epithelial-mesenchymal cell signaling positive regulation of tooth mineralization nephron tubule formation nephron tubule development uc007bne.1 uc007bne.2 uc007bne.3 
ENSMUST00000006718.15 Wnt10a ENSMUST00000006718.15 wingless-type MMTV integration site family, member 10A (from RefSeq NM_009518.2) ENSMUST00000006718.1 ENSMUST00000006718.10 ENSMUST00000006718.11 ENSMUST00000006718.12 ENSMUST00000006718.13 ENSMUST00000006718.14 ENSMUST00000006718.2 ENSMUST00000006718.3 ENSMUST00000006718.4 ENSMUST00000006718.5 ENSMUST00000006718.6 ENSMUST00000006718.7 ENSMUST00000006718.8 ENSMUST00000006718.9 NM_009518 P70701 WN10A_MOUSE uc007bnf.1 uc007bnf.2 uc007bnf.3 uc007bnf.4 uc007bnf.5 Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in normal ectoderm development. Required for normal tooth development. Required for normal postnatal development and maintenance of tongue papillae and sweat ducts. Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae. Required for normal expression of KRT9 in foot plant epithelium. Required for normal hair follicle function. Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids. Secreted, extracellular space, extracellular matrix Secreted Detected in foot plant epidermis, footpad epidermis, haired skin epidermis. Detected in adult epithelia, including filiform and fungiform papillae and sweat ducts. Detected in sweat gland myoepithelial cells, but not in sweat gland mesenchyme. Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. Belongs to the Wnt family. hair follicle development receptor binding frizzled binding extracellular region extracellular space signal transduction cell-cell signaling multicellular organism development animal organ morphogenesis positive regulation of gene expression neural crest cell differentiation Wnt signaling pathway neuron differentiation hair follicle morphogenesis odontogenesis regulation of odontogenesis of dentin-containing tooth tongue development skin development cell fate commitment receptor agonist activity epidermis morphogenesis sebaceous gland development canonical Wnt signaling pathway cellular response to transforming growth factor beta stimulus uc007bnf.1 uc007bnf.2 uc007bnf.3 uc007bnf.4 uc007bnf.5 
ENSMUST00000006721.3 Cryba2 ENSMUST00000006721.3 crystallin, beta A2 (from RefSeq NM_021541.3) CRBA2_MOUSE ENSMUST00000006721.1 ENSMUST00000006721.2 NM_021541 Q540J7 Q9JJV1 uc007bni.1 uc007bni.2 uc007bni.3 Crystallins are the dominant structural components of the vertebrate eye lens. Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity). Has a two-domain beta-structure, folded into four very similar Greek key motifs. Belongs to the beta/gamma-crystallin family. lens development in camera-type eye structural constituent of eye lens visual perception protein homodimerization activity uc007bni.1 uc007bni.2 uc007bni.3 
ENSMUST00000006742.11 Atp7b ENSMUST00000006742.11 ATPase, Cu++ transporting, beta polypeptide, transcript variant 3 (from RefSeq NR_175403.1) ATP7B_MOUSE B1AQ56 ENSMUST00000006742.1 ENSMUST00000006742.10 ENSMUST00000006742.2 ENSMUST00000006742.3 ENSMUST00000006742.4 ENSMUST00000006742.5 ENSMUST00000006742.6 ENSMUST00000006742.7 ENSMUST00000006742.8 ENSMUST00000006742.9 NR_175403 Q64446 Wnd uc009lck.1 uc009lck.2 uc009lck.3 Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. Reaction=ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:25792, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:49552, ChEBI:CHEBI:456216; EC=7.2.2.8; Evidence=; Monomer. Interacts with COMMD1/MURR1 (By similarity). Interacts with DCTN4, in a copper-dependent manner (By similarity). Interacts with ATOX1 (By similarity). Interacts (via C-terminus) with ZBTB16/PLZF (By similarity). Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Late endosome Note=Predominantly found in the trans-Golgi network (TGN). Not redistributed to the plasma membrane in response to elevated copper levels. Detected in liver and kidney. Each HMA domain can bind a copper ion, they are tightly packed and closely interact with each other. Wild-type ATP7B can usually be loaded with an average 5.5 copper atoms per molecule (By similarity). Note=Defects in Atp7b are the cause of the toxic milk mouse mutant (tx) phenotype, characterized by accumulation of copper in the liver in a manner similar to that observed in patients with Wilson disease. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. nucleotide binding copper ion transmembrane transporter activity copper ion binding ATP binding endosome late endosome endoplasmic reticulum Golgi apparatus trans-Golgi network plasma membrane bicellular tight junction ion transport cation transport copper ion transport cellular copper ion homeostasis cellular zinc ion homeostasis lactation zinc ion binding copper ion import intracellular copper ion transport membrane integral component of membrane basolateral plasma membrane cation-transporting ATPase activity metal ion transport cytoplasmic vesicle trans-Golgi network membrane copper-transporting ATPase activity apical part of cell response to copper ion metal ion binding perinuclear region of cytoplasm sequestering of calcium ion copper ion export occluding junction cellular response to copper ion cellular response to manganese ion divalent inorganic cation transport uc009lck.1 uc009lck.2 uc009lck.3 
ENSMUST00000006745.4 Defb2 ENSMUST00000006745.4 defensin beta 2 (from RefSeq NM_010030.2) Defb2 ENSMUST00000006745.1 ENSMUST00000006745.2 ENSMUST00000006745.3 NM_010030 Q32MH3 Q32MH3_MOUSE uc009lca.1 uc009lca.2 uc009lca.3 Secreted extracellular region defense response uc009lca.1 uc009lca.2 uc009lca.3 
ENSMUST00000006749.10 Slc4a1 ENSMUST00000006749.10 solute carrier family 4 (anion exchanger), member 1 (from RefSeq NM_011403.2) ENSMUST00000006749.1 ENSMUST00000006749.2 ENSMUST00000006749.3 ENSMUST00000006749.4 ENSMUST00000006749.5 ENSMUST00000006749.6 ENSMUST00000006749.7 ENSMUST00000006749.8 ENSMUST00000006749.9 NM_011403 Q53ZN9 Q53ZN9_MOUSE Slc4a1 uc007lrp.1 uc007lrp.2 uc007lrp.3 uc007lrp.4 Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) + hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996; Evidence=; Cell membrane ; Multi-pass membrane protein Membrane ; Multi- pass membrane protein Belongs to the anion exchanger (TC 2.A.31) family. inorganic anion exchanger activity integral component of plasma membrane ion transport anion transport anion transmembrane transporter activity bicarbonate transmembrane transporter activity anion:anion antiporter activity inorganic anion transport bicarbonate transport membrane integral component of membrane basolateral plasma membrane ankyrin binding cortical cytoskeleton protein homodimerization activity anion transmembrane transport uc007lrp.1 uc007lrp.2 uc007lrp.3 uc007lrp.4 
ENSMUST00000006750.8 Rundc3a ENSMUST00000006750.8 RUN domain containing 3A, transcript variant 1 (from RefSeq NM_016759.5) A2A693 A2A694 ENSMUST00000006750.1 ENSMUST00000006750.2 ENSMUST00000006750.3 ENSMUST00000006750.4 ENSMUST00000006750.5 ENSMUST00000006750.6 ENSMUST00000006750.7 NM_016759 O08576 Q80Y95 RUN3A_MOUSE Rap2ip Rpip8 uc007lrr.1 uc007lrr.2 uc007lrr.3 uc007lrr.4 uc007lrr.5 May act as an effector of RAP2A in neuronal cells. Interacts with the GTP-bound form of RAP2A. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O08576-1; Sequence=Displayed; Name=2; IsoId=O08576-2; Sequence=VSP_032157, VSP_032159, VSP_032160; Name=3; IsoId=O08576-3; Sequence=VSP_032159, VSP_032160; Name=4; IsoId=O08576-4; Sequence=VSP_032158, VSP_032159, VSP_032160; Brain. Belongs to the RUNDC3 family. cytosol plasma membrane positive regulation of cGMP-mediated signaling uc007lrr.1 uc007lrr.2 uc007lrr.3 uc007lrr.4 uc007lrr.5 
ENSMUST00000006760.3 Cdt1 ENSMUST00000006760.3 chromatin licensing and DNA replication factor 1 (from RefSeq NM_026014.3) CDT1_MOUSE Cdt1 ENSMUST00000006760.1 ENSMUST00000006760.2 NM_026014 Q8BUQ1 Q8BX29 Q8R3V0 Q8R4E8 Q8R4E9 Ris2 uc009ntd.1 uc009ntd.2 uc009ntd.3 Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini- chromosome maintenance (MCM) complex onto DNA to generate pre- replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments (By similarity). Potential oncogene (PubMed:11850834). Interacts with GMNN; the interaction inhibits the binding of the MCM complex to origins of replication (PubMed:12192004, PubMed:15811859). Interacts with MCM6 (PubMed:15811859). Interacts with CDC6; are mutually dependent on one another for loading MCM complexes onto chromatin (By similarity). Interacts with PCNA (By similarity). Interacts with LRWD1 during G1 phase and during mitosis (By similarity). Interacts with NDC80 subunit of the NDC80 complex; leading to kinetochore localization (By similarity). Interacts with KAT7 (By similarity). Interacts with ubiquitin-binding protein FAF1; the interaction is likely to promote CDT1 degradation (By similarity). Q8R4E9; O88513: Gmnn; NbExp=3; IntAct=EBI-457043, EBI-445922; Q8R4E9; P97311: Mcm6; NbExp=2; IntAct=EBI-457043, EBI-457132; Nucleus Chromosome, centromere, kinetochore Note=Transiently localizes to kinetochores during prometaphase and metaphase. Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases. The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination. Two independent E3 ubiquitin ligase complexes, SCF(SKP2) and the DCX(DTL) complex, mediated CDT1 degradation in S phase. Ubiquitinated by the DCX(DTL) complex, in response to DNA damage, leading to its degradation. Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. Phosphorylation at Thr-28 by CDK2 targets CDT1 for ubiquitynation by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation. The interaction with GMNN protects it against ubiquitination. Deubiquitinated by USP37. Phosphorylation by cyclin A-dependent kinases at Thr-28 targets CDT1 for ubiquitynation by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation. Phosphorylated at Thr-28 by MAPK8/JNK1, which blocks replication licensing in response to stress. Binding to GMNN is not affected by phosphorylation (PubMed:14993212). Belongs to the Cdt1 family. Was originally thought to have DNA binding activity (PubMed:12192004). However, more recent studies show that CDT1 binds DNA indirectly via ORC. Sequence=BAC38731.1; Type=Frameshift; Evidence=; DNA replication checkpoint mitotic cell cycle mitotic cytokinesis chromosome, centromeric region kinetochore condensed chromosome kinetochore DNA binding chromatin binding protein binding nucleus chromosome DNA replication cell cycle chromosome segregation nuclear body regulation of DNA-dependent DNA replication initiation positive regulation of protein complex assembly regulation of chromosome organization regulation of nuclear cell cycle DNA replication positive regulation of chromatin binding positive regulation of DNA replication cell division attachment of mitotic spindle microtubules to kinetochore kinetochore organization DNA polymerase binding DNA replication preinitiation complex assembly response to sorbitol deactivation of mitotic spindle assembly checkpoint regulation of DNA replication origin binding negative regulation of protein localization to kinetochore positive regulation of protein localization to kinetochore positive regulation of DNA-dependent DNA replication uc009ntd.1 uc009ntd.2 uc009ntd.3 
ENSMUST00000006762.7 Snai3 ENSMUST00000006762.7 snail family zinc finger 3 (from RefSeq NM_013914.3) ENSMUST00000006762.1 ENSMUST00000006762.2 ENSMUST00000006762.3 ENSMUST00000006762.4 ENSMUST00000006762.5 ENSMUST00000006762.6 NM_013914 Q3U3U2 Q496S5 Q8C244 Q9QY31 SNAI3_MOUSE Smuc Zfp293 uc009nsw.1 uc009nsw.2 uc009nsw.3 Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'- CAGGTG-3' and 5'-CACCTG-3'. Nucleus Highly expressed in skeletal muscle and thymus. Lower expression in heart, lung and spleen. Expressed at 7 dpc, higher expression observed in stages 15 dpc and 18 dpc. Binds E-box via C2H2-type zinc finger domain. Belongs to the snail C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter metal ion binding uc009nsw.1 uc009nsw.2 uc009nsw.3 
ENSMUST00000006764.9 Aprt ENSMUST00000006764.9 adenine phosphoribosyl transferase (from RefSeq NM_009698.2) APT_MOUSE Aprt ENSMUST00000006764.1 ENSMUST00000006764.2 ENSMUST00000006764.3 ENSMUST00000006764.4 ENSMUST00000006764.5 ENSMUST00000006764.6 ENSMUST00000006764.7 ENSMUST00000006764.8 NM_009698 P08030 Q564P4 Q61319 Q6PK77 Q9DCY3 uc009ntf.1 uc009ntf.2 uc009ntf.3 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Reaction=AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine; Xref=Rhea:RHEA:16609, ChEBI:CHEBI:16708, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:456215; EC=2.4.2.7; Evidence=; Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. Homodimer. Cytoplasm. Belongs to the purine/pyrimidine phosphoribosyltransferase family. adenine binding adenine phosphoribosyltransferase activity nucleoplasm cytoplasm cytosol purine ribonucleoside salvage adenine salvage lactation grooming behavior nucleoside metabolic process AMP binding transferase activity transferase activity, transferring glycosyl groups cellular response to insulin stimulus AMP salvage adenine metabolic process uc009ntf.1 uc009ntf.2 uc009ntf.3 
ENSMUST00000006774.11 Gtf2h1 ENSMUST00000006774.11 general transcription factor II H, polypeptide 1, transcript variant 2 (from RefSeq NM_008186.4) ENSMUST00000006774.1 ENSMUST00000006774.10 ENSMUST00000006774.2 ENSMUST00000006774.3 ENSMUST00000006774.4 ENSMUST00000006774.5 ENSMUST00000006774.6 ENSMUST00000006774.7 ENSMUST00000006774.8 ENSMUST00000006774.9 G3X8R4 G3X8R4_MOUSE Gtf2h1 NM_008186 uc009gzk.1 uc009gzk.2 uc009gzk.3 uc009gzk.4 Nucleus Belongs to the TFB1 family. core TFIIH complex nucleotide-excision repair transcription, DNA-templated uc009gzk.1 uc009gzk.2 uc009gzk.3 uc009gzk.4 
ENSMUST00000006792.6 Ncr1 ENSMUST00000006792.6 natural cytotoxicity triggering receptor 1, transcript variant 1 (from RefSeq NM_010746.3) A0A0R4IZY7 A0A0R4IZY7_MOUSE ENSMUST00000006792.1 ENSMUST00000006792.2 ENSMUST00000006792.3 ENSMUST00000006792.4 ENSMUST00000006792.5 NM_010746 Ncr1 uc009exi.1 uc009exi.2 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the natural cytotoxicity receptor (NCR) family. membrane integral component of membrane uc009exi.1 uc009exi.2 
ENSMUST00000006818.4 Tcf23 ENSMUST00000006818.4 transcription factor 23 (from RefSeq NM_053085.2) ENSMUST00000006818.1 ENSMUST00000006818.2 ENSMUST00000006818.3 NM_053085 Out Q9JLR5 TCF23_MOUSE uc008wws.1 uc008wws.2 uc008wws.3 Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. May be involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. Seems to play a role in the inhibition of myogenesis. Forms inactive heterodimeric complex with TCF3. Nucleus Highly expressed in the uterus (predominantly in myometrium), ovary, and testis. Expression in the uterus is higher in the diestrus phase than in the estrus phase and reaches a maximum at 7.5 dpc. Expression declines towards the time of delivery and returns to the non-pregnant level 4 days after delivery. Low expression seen in lung, heart, intestine, and spleen. Both the bHLH region and the C-terminal portion are essential for inhibitory function. nucleus multicellular organism development muscle organ development positive regulation of gene expression cell differentiation decidualization protein dimerization activity uc008wws.1 uc008wws.2 uc008wws.3 
ENSMUST00000006825.9 Nphs1 ENSMUST00000006825.9 nephrosis 1, nephrin (from RefSeq NM_019459.2) D2KXA7 ENSMUST00000006825.1 ENSMUST00000006825.2 ENSMUST00000006825.3 ENSMUST00000006825.4 ENSMUST00000006825.5 ENSMUST00000006825.6 ENSMUST00000006825.7 ENSMUST00000006825.8 NM_019459 NPHN_MOUSE Nphn Q811S5 Q925S5 Q9ESC6 Q9ET59 Q9JIX1 Q9QZS7 uc009gen.1 uc009gen.2 uc009gen.3 Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion. Interacts with NPHS2 and with CD2AP (via C-terminal domain). Interacts with MAGI1 (via PDZ 2 and 3 domains) forming a tripartite complex with IGSF5/JAM4. Forms a complex with ACTN4, CASK, IQGAP1, MAGI2, SPTAN1 and SPTBN1 (By similarity). Interacts with DDN; the interaction is direct. Self-associates (via the Ig-like domains). Also interacts (via the Ig-like domains) with KIRREL1 and KIRREL2; the interaction with KIRREL1 is dependent on KIRREL1 glycosylation. Interacts with KIRREL3 (PubMed:15843475, PubMed:18752272). Interacts with phosphatidylinositol 3-kinase regulatory subunit PIK3R1; the interaction is reduced by high glucose levels (By similarity). Cell membrane ; Single-pass type I membrane protein Note=Located at podocyte slit diaphragm between podocyte foot processes. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=NephrinA; IsoId=Q9QZS7-1; Sequence=Displayed; Name=2; Synonyms=NephrinB; IsoId=Q9QZS7-2; Sequence=VSP_040676; Expressed in kidney glomeruli. In the embryo, expressed in the mesonephric kidney at 11 dpc with strong expression in cranial tubules with podocyte-like structures. Expression is observed in the podocytes of the developing kidney from 13 dpc. High expression is also detected in the developing cerebellum, hindbrain, spinal cord, retina and hypothalamus. Expressed in skeletal muscle during myoblast fusion such as in the adult following acute injury and in the embryo but not detected in uninjured adult skeletal muscle. Isoform 1 and isoform 2 are expressed in the newborn brain and developing cerebellum. Isoform 1 is the predominant isoform in adult kidney. Phosphorylated at Tyr-1208 by FYN, leading to the recruitment and activation of phospholipase C-gamma-1/PLCG1 (By similarity). Tyrosine phosphorylation is reduced by high glucose levels (By similarity). Dephosphorylated by tensin TNS2 which leads to reduced binding of NPHN1 to PIK3R1 (By similarity). Death by postnatal day 2 associated with proteinuria, edema and massive glomerular vascular leak. Kidneys display enlarged Bowman's spaces, dilated tubuli, effacement of podocyte foot processes and an absence of the glomerular epithelial slit diaphragm. Impaired skeletal muscle development characterized by incomplete myoblast fusion. Belongs to the immunoglobulin superfamily. MAPK cascade protein binding plasma membrane integral component of plasma membrane focal adhesion cell adhesion JNK cascade multicellular organism development muscle organ development skeletal muscle tissue development myoblast fusion membrane integral component of membrane myosin binding protein domain specific binding spectrin binding positive regulation of actin filament polymerization glomerular basement membrane development macromolecular complex protein localization to synapse slit diaphragm cell projection regulation of excretion membrane raft alpha-actinin binding glomerular visceral epithelial cell development uc009gen.1 uc009gen.2 uc009gen.3 
ENSMUST00000006828.9 Aplp1 ENSMUST00000006828.9 amyloid beta precursor like protein 1 (from RefSeq NM_007467.4) A0A0R4IZZ1 APLP1_MOUSE ENSMUST00000006828.1 ENSMUST00000006828.2 ENSMUST00000006828.3 ENSMUST00000006828.4 ENSMUST00000006828.5 ENSMUST00000006828.6 ENSMUST00000006828.7 ENSMUST00000006828.8 NM_007467 Q03157 Q3U311 Q8VC38 uc009gek.1 uc009gek.2 uc009gek.3 uc009gek.4 May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G- protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. Monomer and homodimer. Heparin binding promotes homodimerization. Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB and APBA family members, MAPK8IP1 and DAB1 (By similarity). Binding to Dab1 inhibits its serine phosphorylation. Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Interacts (via NPXY motif) with DAB1. Q03157; P12023: App; NbExp=4; IntAct=EBI-399929, EBI-78814; Q03157; P97318: Dab1; NbExp=4; IntAct=EBI-399929, EBI-81680; Cell membrane; Single-pass type I membrane protein. [C30]: Cytoplasm. Note=C-terminally processed in the Golgi complex. The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis. Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-624 by caspase-3 (By similarity). N- and O-glycosylated. Binds zinc and copper in the extracellular domain. Zinc- binding increases heparin binding. No Cu(2+) reducing activity with copper-binding. Belongs to the APP family. protein binding cytoplasm Golgi apparatus plasma membrane mRNA polyadenylation regulation of translation endocytosis apoptotic process cell adhesion heparin binding membrane integral component of membrane extracellular matrix organization forebrain development alpha-2A adrenergic receptor binding alpha-2B adrenergic receptor binding alpha-2C adrenergic receptor binding identical protein binding metal ion binding transition metal ion binding perinuclear region of cytoplasm cellular response to norepinephrine stimulus uc009gek.1 uc009gek.2 uc009gek.3 uc009gek.4 
ENSMUST00000006838.16 Qars1 ENSMUST00000006838.16 glutaminyl-tRNA synthetase 1 (from RefSeq NM_133794.2) ENSMUST00000006838.1 ENSMUST00000006838.10 ENSMUST00000006838.11 ENSMUST00000006838.12 ENSMUST00000006838.13 ENSMUST00000006838.14 ENSMUST00000006838.15 ENSMUST00000006838.2 ENSMUST00000006838.3 ENSMUST00000006838.4 ENSMUST00000006838.5 ENSMUST00000006838.6 ENSMUST00000006838.7 ENSMUST00000006838.8 ENSMUST00000006838.9 NM_133794 Q3TN94 Q8BML9 Q8BU21 Qars SYQ_MOUSE uc009rpy.1 uc009rpy.2 uc009rpy.3 uc009rpy.4 Glutamine--tRNA ligase. Plays a critical role in brain development. Reaction=ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L- glutaminyl-tRNA(Gln); Xref=Rhea:RHEA:20121, Rhea:RHEA-COMP:9662, Rhea:RHEA-COMP:9681, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58359, ChEBI:CHEBI:78442, ChEBI:CHEBI:78521, ChEBI:CHEBI:456215; EC=6.1.1.18; Evidence=; Monomer. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:12060739). Interacts with RARS1. Part of a complex composed of RARS1, QARS1 and AIMP1 (By similarity). Cytoplasm, cytosol Cytoplasm Belongs to the class-I aminoacyl-tRNA synthetase family. nucleotide binding RNA binding aminoacyl-tRNA ligase activity glutamine-tRNA ligase activity protein kinase inhibitor activity ATP binding cytoplasm cytosol translation tRNA aminoacylation for protein translation glutaminyl-tRNA aminoacylation negative regulation of protein kinase activity brain development ligase activity aminoacyl-tRNA synthetase multienzyme complex protein kinase binding negative regulation of stress-activated MAPK cascade macromolecular complex tRNA aminoacylation negative regulation of apoptotic process negative regulation of transcription, DNA-templated negative regulation of apoptotic signaling pathway uc009rpy.1 uc009rpy.2 uc009rpy.3 uc009rpy.4 
ENSMUST00000006851.15 Qrich1 ENSMUST00000006851.15 glutamine-rich 1, transcript variant 1 (from RefSeq NM_001114119.1) ENSMUST00000006851.1 ENSMUST00000006851.10 ENSMUST00000006851.11 ENSMUST00000006851.12 ENSMUST00000006851.13 ENSMUST00000006851.14 ENSMUST00000006851.2 ENSMUST00000006851.3 ENSMUST00000006851.4 ENSMUST00000006851.5 ENSMUST00000006851.6 ENSMUST00000006851.7 ENSMUST00000006851.8 ENSMUST00000006851.9 G3X8R5 G3X8R5_MOUSE NM_001114119 Qrich1 uc009rqd.1 uc009rqd.2 uc009rqd.3 uc009rqd.4 nucleoplasm uc009rqd.1 uc009rqd.2 uc009rqd.3 uc009rqd.4 
ENSMUST00000006853.11 P4htm ENSMUST00000006853.11 prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum), transcript variant 3 (from RefSeq NR_151688.1) ENSMUST00000006853.1 ENSMUST00000006853.10 ENSMUST00000006853.2 ENSMUST00000006853.3 ENSMUST00000006853.4 ENSMUST00000006853.5 ENSMUST00000006853.6 ENSMUST00000006853.7 ENSMUST00000006853.8 ENSMUST00000006853.9 NR_151688 P4HTM_MOUSE Ph4 Q8BG58 Q8CAF1 Q9D499 uc009rqk.1 uc009rqk.2 uc009rqk.3 Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Reaction=2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia- inducible factor alpha subunit]; Xref=Rhea:RHEA:48400, Rhea:RHEA- COMP:12093, Rhea:RHEA-COMP:12094, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50342, ChEBI:CHEBI:61965; EC=1.14.11.29; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Homodimer. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BG58-1; Sequence=Displayed; Name=2; IsoId=Q8BG58-2; Sequence=VSP_007575, VSP_007576; Highest expression levels are detected in the eye and brain, especially in the retinal epithelium cells and cortical neurons. Also expressed in skeletal muscle, lung, heart, adrenal gland, kidney, prostate, thyroid and testis. Glycosylated. Mutant mice exhibit inflammation and fibrosis of renal tubuli, glomerular sclerosis, enlarged Bowman capsules, and develop late-onset proteinuria. Vision is compromised, primarily due to impairment of cone function. Sequence=BAB30379.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; Sequence=BAC30172.1; Type=Frameshift; Evidence=; iron ion binding calcium ion binding endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors peptidyl-proline hydroxylation to 4-hydroxy-L-proline L-ascorbic acid binding regulation of erythrocyte differentiation metal ion binding dioxygenase activity oxidation-reduction process procollagen-proline 4-dioxygenase activity uc009rqk.1 uc009rqk.2 uc009rqk.3 
ENSMUST00000006854.13 Usp19 ENSMUST00000006854.13 ubiquitin specific peptidase 19, transcript variant 1 (from RefSeq NM_027804.4) ENSMUST00000006854.1 ENSMUST00000006854.10 ENSMUST00000006854.11 ENSMUST00000006854.12 ENSMUST00000006854.2 ENSMUST00000006854.3 ENSMUST00000006854.4 ENSMUST00000006854.5 ENSMUST00000006854.6 ENSMUST00000006854.7 ENSMUST00000006854.8 ENSMUST00000006854.9 Kiaa0891 NM_027804 Q3TAC9 Q3TUE6 Q3UJD6 Q6P9T0 Q80TP5 Q80ZW5 UBP19_MOUSE uc009rpt.1 uc009rpt.2 uc009rpt.3 uc009rpt.4 Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (By similarity). Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing thier ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains (By similarity). Plays an important role in 17 beta- estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Interacts with and stabilizes RNF123 (By similarity). Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with HIF1A (via N-terminus) (By similarity). Q3UJD6-2; O75344: FKBP6; Xeno; NbExp=2; IntAct=EBI-9359023, EBI-744771; Endoplasmic reticulum membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UJD6-1; Sequence=Displayed; Name=2; IsoId=Q3UJD6-2; Sequence=VSP_026769, VSP_026770; Up-regulated by ESR1 in the presence of 17 beta-estradiol (E2). Sequence=BAC65678.4; Type=Erroneous initiation; Evidence=; thiol-dependent ubiquitin-specific protease activity protein binding endoplasmic reticulum endoplasmic reticulum membrane cytosol proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity membrane integral component of membrane protein deubiquitination hydrolase activity ER-associated ubiquitin-dependent protein catabolic process ubiquitin protein ligase binding regulation of protein stability response to endoplasmic reticulum stress thiol-dependent ubiquitinyl hydrolase activity metal ion binding negative regulation of skeletal muscle tissue development protein stabilization Hsp90 protein binding protein K48-linked deubiquitination positive regulation of cell cycle process regulation of cellular response to hypoxia negative regulation of proteasomal protein catabolic process regulation of ERAD pathway Lys48-specific deubiquitinase activity uc009rpt.1 uc009rpt.2 uc009rpt.3 uc009rpt.4 
ENSMUST00000006856.3 Pola1 ENSMUST00000006856.3 polymerase (DNA directed), alpha 1 (from RefSeq NM_008892.2) DPOLA_MOUSE ENSMUST00000006856.1 ENSMUST00000006856.2 NM_008892 P33609 Pola uc009tss.1 uc009tss.2 uc009tss.3 uc009tss.4 Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:8253737, PubMed:8026492). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses. Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22509; Evidence=; Component of the alpha DNA polymerase complex (also known as the alpha DNA polymerase-primase complex) consisting of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the primase complex subunits PRIM1 and PRIM2 respectively (PubMed:8253737, PubMed:8026492). Within the complex, POLA1 directly interacts with PRIM2 (PubMed:8253737). Interacts with PARP1; this interaction functions as part of the control of replication fork progression. Interacts with MCM10 and WDHD1; these interactions recruit the polymerase alpha complex to the pre-replicative complex bound to DNA. Interacts with RPA1; this interaction stabilizes the replicative complex and reduces the misincorporation rate of DNA polymerase alpha by acting as a fidelity clamp (By similarity). P33609; P33611: Pola2; NbExp=5; IntAct=EBI-688051, EBI-848759; P33609; P20664: Prim1; NbExp=4; IntAct=EBI-688051, EBI-848742; Nucleus Cytoplasm, cytosol Note=In the cytosol, colocalizes with RNA:DNA hybrids with a speckled pattern. Expressed in those zones containing proliferating cells in the developing embryonic neocortex, as well as in the lateral and medial ganglionic eminences. After birth, expressed in cells that remain proliferating in the ventricular and subventricular zone of the striatum. In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis. Conserved regions II, IV, III and I are thought to be involved in substrate recognition, binding or PP(i) hydrolysis. Belongs to the DNA polymerase type-B family. nucleotide binding DNA synthesis involved in DNA repair nucleoside binding nucleic acid binding DNA binding chromatin binding DNA replication origin binding double-stranded DNA binding single-stranded DNA binding DNA-directed DNA polymerase activity protein binding nucleus nuclear envelope nucleoplasm alpha DNA polymerase:primase complex nucleolus cytoplasm cytosol DNA replication DNA replication, synthesis of RNA primer DNA replication initiation DNA strand elongation involved in DNA replication leading strand elongation lagging strand elongation double-strand break repair via nonhomologous end joining cell proliferation nuclear matrix transferase activity nucleotidyltransferase activity purine nucleotide binding pyrimidine nucleotide binding protein kinase binding metal ion binding protein heterodimerization activity iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding DNA biosynthetic process mitotic DNA replication initiation chromatin DNA repair DNA synthesis involved in UV-damage excision repair uc009tss.1 uc009tss.2 uc009tss.3 uc009tss.4 
ENSMUST00000006893.9 D130043K22Rik ENSMUST00000006893.9 RIKEN cDNA D130043K22 gene, transcript variant 1 (from RefSeq NM_001081051.2) ENSMUST00000006893.1 ENSMUST00000006893.2 ENSMUST00000006893.3 ENSMUST00000006893.4 ENSMUST00000006893.5 ENSMUST00000006893.6 ENSMUST00000006893.7 ENSMUST00000006893.8 K0319_MOUSE Kiaa0319 NM_001081051 Q14BF3 Q5SZV5 Q80U39 uc007pwn.1 uc007pwn.2 uc007pwn.3 uc007pwn.4 This gene encodes a transmembrane protein that contains a large extracellular domain with multiple polycystic kidney disease (PKD) domains. The encoded protein may play a role in the development of the cerebral cortex by regulating neuronal migration and cell adhesion. Single nucleotide polymorphisms in a similar gene in human are associated with dyslexia. Alternatively spliced transcript variants have been identifed. [provided by RefSeq, May 2015]. Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites (By similarity). Homodimer. Interacts with AP2M1; required for clathrin- mediated endocytosis (By similarity). Cell membrane ; Single-pass type I membrane protein Early endosome membrane ; Single-pass type I membrane protein Expressed in the frontal neocortex, glanglionic eminence, mesencephalon and cerebellum at 13.5 dpc. More prominently expressed in the developing cerebral neocortex and mesencephalon at 15.5 dpc and in the cortical plate and in the remnant of the ventricular zone at 18.5 dpc. N-glycosylated. O-glycosylated. Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus (By similarity). Sequence=BAC65528.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; neuron migration molecular_function endosome early endosome plasma membrane multicellular organism development nervous system development response to auditory stimulus membrane integral component of membrane cytoplasmic vesicle early endosome membrane multicellular organismal response to stress intracellular membrane-bounded organelle negative regulation of dendrite development neurogenesis uc007pwn.1 uc007pwn.2 uc007pwn.3 uc007pwn.4 
ENSMUST00000006900.7 Acot13 ENSMUST00000006900.7 acyl-CoA thioesterase 13 (from RefSeq NM_025790.2) ACO13_MOUSE Acot13 ENSMUST00000006900.1 ENSMUST00000006900.2 ENSMUST00000006900.3 ENSMUST00000006900.4 ENSMUST00000006900.5 ENSMUST00000006900.6 NM_025790 Q9CQR4 Them2 uc007pwj.1 uc007pwj.2 uc007pwj.3 Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:19405909). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (PubMed:19405909). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity). May play a role in controlling adaptive thermogenesis (PubMed:24072708). Reaction=a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+); Xref=Rhea:RHEA:16781, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57287, ChEBI:CHEBI:77636; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16782; Evidence=; Reaction=decanoyl-CoA + H2O = CoA + decanoate + H(+); Xref=Rhea:RHEA:40059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40060; Evidence=; Reaction=H2O + octanoyl-CoA = CoA + H(+) + octanoate; Xref=Rhea:RHEA:30143, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30144; Evidence=; Reaction=butanoyl-CoA + H2O = butanoate + CoA + H(+); Xref=Rhea:RHEA:40111, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40112; Evidence=; Reaction=H2O + hexanoyl-CoA = CoA + H(+) + hexanoate; Xref=Rhea:RHEA:40115, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57287, ChEBI:CHEBI:62620; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40116; Evidence=; Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=; Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence=; Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40140; Evidence=; Kinetic parameters: KM=138 uM for hexanoyl-CoA (at 37 degrees Celsius) ; KM=47 uM for decanoyl-CoA (at 37 degrees Celsius) ; KM=27 uM for lauroyl-CoA/dodecanoyl-CoA (at 37 degrees Celsius) ; KM=15 uM for myristoyl-CoA/tetradecanoyl-CoA (at 37 degrees Celsius) ; KM=7 uM for myristoyl-CoA/tetradecanoyl-CoA (at 25 degrees Celsius) ; KM=21 uM for myristoyl-CoA/tetradecanoyl-CoA (at 50 degrees Celsius) ; KM=10 uM for palmitoyl-CoA/hexadecanoyl-CoA (at 37 degrees Celsius) ; KM=27 uM for oleoyl-CoA/(9Z)-octadecenoyl-CoA (at 37 degrees Celsius) ; KM=162 uM for beta-hydroxybutyryl-CoA (at 37 degrees Celsius) ; KM=305 uM for (3S)-hydroxy-3-methylglutaryl-CoA (at 37 degrees Celsius) ; KM=142 uM for malonyl-CoA (at 37 degrees Celsius) ; KM=191 uM for phenylacetyl-CoA (at 37 degrees Celsius) ; Vmax=29 nmol/min/mg enzyme with hexanoyl-CoA as substrate (at 37 degrees Celsius) ; Vmax=54 nmol/min/mg enzyme with decanoyl-CoA as substrate (at 37 degrees Celsius) ; Vmax=37 nmol/min/mg enzyme with dodecanoyl-CoA as substrate (at 37 degrees Celsius) ; Vmax=46 nmol/min/mg enzyme with tetradecanoyl-CoA as substrate (at 37 degrees Celsius) ; Vmax=30 nmol/min/mg enzyme with tetradecanoyl-CoA as substrate (at 25 degrees Celsius) ; Vmax=61 nmol/min/mg enzyme with tetradecanoyl-CoA as substrate (at 50 degrees Celsius) ; Vmax=38 nmol/min/mg enzyme with hexadecanoyl-CoA as substrate (at 37 degrees Celsius) ; Vmax=60 nmol/min/mg enzyme with (9Z)-octadecenoyl-CoA as substrate (at 37 degrees Celsius) ; Vmax=45 nmol/min/mg enzyme with beta-hydroxybutyryl-CoA as substrate (at 37 degrees Celsius) ; Vmax=6 nmol/min/mg enzyme with (3S)-hydroxy-3-methylglutaryl-CoA as substrate (at 37 degrees Celsius) ; Vmax=14 nmol/min/mg enzyme with malonyl-CoA as substrate (at 37 degrees Celsius) ; Vmax=119 nmol/min/mg enzyme with phenylacetyl-CoA as substrate (at 37 degrees Celsius) ; Note=kcat is 3 sec(-1) for hexanoyl-CoA hydrolase activity (at 37 degrees Celsius) (PubMed:19405909). kcat is 5 sec(-1) for decanoyl- CoA hydrolase activity (at 37 degrees Celsius) (PubMed:19405909). kcat is 3 sec(-1) for dodecanoyl-CoA hydrolase activity (at 37 degrees Celsius) (PubMed:19405909). kcat is 4 sec(-1) for tetradecanoyl-CoA hydrolase activity (at 37 degrees Celsius) (PubMed:19405909). kcat is 3 sec(-1) for tetradecanoyl-CoA hydrolase activity (at 25 degrees Celsius) (PubMed:19405909). kcat is 6 sec(-1) for tetradecanoyl-CoA hydrolase activity (at 50 degrees Celsius) (PubMed:19405909). kcat is 3 sec(-1) for hexadecanoyl-CoA hydrolase activity (at 37 degrees Celsius) (PubMed:19405909). kcat is 6 sec(-1) for (9Z)-octadecenoyl-CoA hydrolase activity (at 37 degrees Celsius) (PubMed:19405909). kcat is 4 sec(-1) for beta-hydroxybutyryl-CoA hydrolase activity (at 37 degrees Celsius) (PubMed:19405909). kcat is 7 sec(-1) for (3S)-hydroxy-3-methylglutaryl-CoA hydrolase activity (at 37 degrees Celsius) (PubMed:19405909). kcat is 1 sec(-1) for malonyl-CoA hydrolase activity (at 37 degrees Celsius) (PubMed:19405909). kcat is 1 sec(-1) for phenylacetyl-CoA hydrolase activity (at 37 degrees Celsius) (PubMed:19405909). ; Homotetramer. Interacts with PCTP. Cytoplasm, cytosol Mitochondrion Nucleus Cytoplasm, cytoskeleton, spindle Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin. Highly expressed in the kidney and moderately in the heart, liver, brain, small and large intestine. Also expressed in brown adipose tissue. No visible phenotype until 7 weeks of age. Animals are viable and fertile. After 7 weeks, mutant mice exhibit a modest decrease in body weight and decreased adiposity, compared to wild-type animals, despite increased food consumption. They tend to show a reduced hepatic fatty acyl-CoA thioesterase activity, leading to alterations in fatty acid metabolism and improved glucose homeostasis. When fed a high-fat diet, mutant livers are protected against steatosis and increased hepatic glucose production (PubMed:22345407). Mutant mice adapt more rapidly than wild-type to short-term cold exposure by increasing physical activity, food consumption and energy expenditure. After 96-hour equilibration at cold temperature, genotype-dependent differences are abolished. Mutant brown adipose tissue show reduced lipid droplets, alterations in the ultrastructure of mitochondria and a small increase in the expression of thermogenic genes (PubMed:24072708). Belongs to the thioesterase PaaI family. nucleus cytoplasm mitochondrion spindle cytosol cytoskeleton hydrolase activity acyl-CoA hydrolase activity protein homotetramerization uc007pwj.1 uc007pwj.2 uc007pwj.3 
ENSMUST00000006911.12 Cdk4 ENSMUST00000006911.12 cyclin dependent kinase 4, transcript variant 1 (from RefSeq NM_009870.4) Cdk4 ENSMUST00000006911.1 ENSMUST00000006911.10 ENSMUST00000006911.11 ENSMUST00000006911.2 ENSMUST00000006911.3 ENSMUST00000006911.4 ENSMUST00000006911.5 ENSMUST00000006911.6 ENSMUST00000006911.7 ENSMUST00000006911.8 ENSMUST00000006911.9 NM_009870 Q545C3 Q545C3_MOUSE uc007hhv.1 uc007hhv.2 uc007hhv.3 uc007hhv.4 uc007hhv.5 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=; Nucleus membrane Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. G1/S transition of mitotic cell cycle nucleotide binding cyclin-dependent protein kinase holoenzyme complex chromatin lens development in camera-type eye protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus nucleolus cytosol protein phosphorylation circadian rhythm positive regulation of cell proliferation response to toxic substance response to organic substance response to lead ion regulation of gene expression positive regulation of G2/M transition of mitotic cell cycle cyclin binding animal organ regeneration nuclear membrane response to testosterone response to drug positive regulation of apoptotic process macromolecular complex binding positive regulation of translation positive regulation of cell size positive regulation of fibroblast proliferation perinuclear region of cytoplasm response to hyperoxia negative regulation of cell cycle arrest uc007hhv.1 uc007hhv.2 uc007hhv.3 uc007hhv.4 uc007hhv.5 
ENSMUST00000006912.12 Pip4k2a ENSMUST00000006912.12 phosphatidylinositol-5-phosphate 4-kinase, type II, alpha, transcript variant 1 (from RefSeq NM_008845.4) ENSMUST00000006912.1 ENSMUST00000006912.10 ENSMUST00000006912.11 ENSMUST00000006912.2 ENSMUST00000006912.3 ENSMUST00000006912.4 ENSMUST00000006912.5 ENSMUST00000006912.6 ENSMUST00000006912.7 ENSMUST00000006912.8 ENSMUST00000006912.9 NM_008845 Pip4k2a Pip5k2a Q544E3 Q544E3_MOUSE uc008imb.1 uc008imb.2 uc008imb.3 Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5- phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:55992, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:83423, ChEBI:CHEBI:84968, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55993; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5- phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + GDP + H(+); Xref=Rhea:RHEA:55964, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:58189, ChEBI:CHEBI:83423, ChEBI:CHEBI:84968; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55965; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:12280, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57795, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.149; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12281; Evidence=; Cell membrane Cytoplasm Lysosome Membrane Nucleus nucleotide binding ATP binding autophagosome regulation of autophagy kinase activity phosphatidylinositol phosphate kinase activity phosphorylation transferase activity phosphatidylinositol metabolic process phosphatidylinositol phosphorylation positive regulation of autophagosome assembly uc008imb.1 uc008imb.2 uc008imb.3 
ENSMUST00000006914.11 B4galnt1 ENSMUST00000006914.11 beta-1,4-N-acetyl-galactosaminyl transferase 1, transcript variant 2 (from RefSeq NM_027739.2) B4galnt1 ENSMUST00000006914.1 ENSMUST00000006914.10 ENSMUST00000006914.2 ENSMUST00000006914.3 ENSMUST00000006914.4 ENSMUST00000006914.5 ENSMUST00000006914.6 ENSMUST00000006914.7 ENSMUST00000006914.8 ENSMUST00000006914.9 Galgt1 NM_027739 Q3UN35 Q3UN35_MOUSE uc007hic.1 uc007hic.2 uc007hic.3 uc007hic.4 Golgi apparatus membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 2 family. Golgi membrane ganglioside biosynthetic process (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity Golgi apparatus plasma membrane acetylgalactosaminyltransferase activity membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups integral component of Golgi membrane lipid glycosylation uc007hic.1 uc007hic.2 uc007hic.3 uc007hic.4 
ENSMUST00000006915.14 Mettl1 ENSMUST00000006915.14 methyltransferase 1, tRNA methylguanosine (from RefSeq NM_010792.1) ENSMUST00000006915.1 ENSMUST00000006915.10 ENSMUST00000006915.11 ENSMUST00000006915.12 ENSMUST00000006915.13 ENSMUST00000006915.2 ENSMUST00000006915.3 ENSMUST00000006915.4 ENSMUST00000006915.5 ENSMUST00000006915.6 ENSMUST00000006915.7 ENSMUST00000006915.8 ENSMUST00000006915.9 Mettl1 NM_010792 Q3TU83 Q921G5 Q9Z120 TRMB_MOUSE uc007hhq.1 uc007hhq.2 uc007hhq.3 Catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (By similarity). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (By similarity). M7G46 interacts with C13-G22 in the D- loop to stabilize tRNA tertiary structure and protect tRNAs from decay (By similarity). Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:29983320). Internal N(7)- methylguanine methylation of mRNAs in response to stress promotes their relocalization to stress granules, thereby suppressing their translation (PubMed:29983320). Also methylates a specific subset of miRNAs, such as let-7 (By similarity). N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (By similarity). Acts as a regulator of embryonic stem cell self-renewal and differentiation (PubMed:29983320). Reaction=guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)- methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42708, Rhea:RHEA-COMP:10188, Rhea:RHEA-COMP:10189, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74480; EC=2.1.1.33; Evidence= Reaction=a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)- methylguanosine in mRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60508, Rhea:RHEA-COMP:15584, Rhea:RHEA-COMP:15585, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74480; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60509; Evidence=; Reaction=a guanosine in miRNA + S-adenosyl-L-methionine = an N(7)- methylguanosine in miRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60512, Rhea:RHEA-COMP:15587, Rhea:RHEA-COMP:15588, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74480; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60513; Evidence=; tRNA modification; N(7)-methylguanine-tRNA biosynthesis. Catalytic component of the METTL1-WDR4 complex, composed of METTL1 and WDR4. Nucleus Upon tRNA-binding, the alphaC region transforms into a helix, which together with the alpha6 helix secures both ends of the tRNA variable loop (By similarity). The N-terminal disordered region is part of the catalytic pocket and essential for methyltransferase activity: upon S-adenosyl-L-methionine- and tRNA-binding, the N-terminal disordered region becomes ordered, sandwiched between the bound cofactor and the tRNA, and the WDR4 C-terminus attaches to the METTL1 N-terminus to stabilize the bound tRNA together (By similarity). Together with WDR4, which also binds tRNAs, tRNAs undergo bending to facilitate G46 flipping into the catalytic pocket to be modified (By similarity). Phosphorylation at Ser-21 by PKB/AKT1 inactivates its methyltransferase activity via a steric interference mechanism in the active site that locally disrupts the catalytic center (By similarity). Phosphorylation at Ser-21 does not affect the interaction with WDR4 (By similarity). Conditional knockout in the liver impairs the formation of N(7)-methylguanine at position 46 (m7G46) in tRNAs and inhibits tumor development in an intrahepatic cholangiocarcinoma xenograph mouse model. In the context of cancer, overexpression of the METTL1- WDR4 methyltransferase complex promotes cancer progression by driving oncogenic transformation (PubMed:34352206). Drives oncogenesis by mediating the formation of N(7)-methylguanine at position 46 (m7G46) in some tRNAs, in particular Arg-TCT-4-1 (TRR-TCT4-1), leading to increased translation of mRNAs, including cell cycle regulators that are enriched in the corresponding AGA codon (PubMed:34352206). Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. tRNA binding RNA binding nucleus nucleoplasm nucleolus cytosol tRNA modification tRNA processing methyltransferase activity tRNA (guanine-N7-)-methyltransferase activity transferase activity tRNA methylation methylation RNA (guanine-N7)-methylation uc007hhq.1 uc007hhq.2 uc007hhq.3 
ENSMUST00000006949.9 Tph2 ENSMUST00000006949.9 tryptophan hydroxylase 2 (from RefSeq NM_173391.3) ENSMUST00000006949.1 ENSMUST00000006949.2 ENSMUST00000006949.3 ENSMUST00000006949.4 ENSMUST00000006949.5 ENSMUST00000006949.6 ENSMUST00000006949.7 ENSMUST00000006949.8 NM_173391 Ntph Q0VBT4 Q8CGV2 TPH2_MOUSE uc007haw.1 uc007haw.2 uc007haw.3 Reaction=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5- hydroxy-L-tryptophan; Xref=Rhea:RHEA:16709, ChEBI:CHEBI:15379, ChEBI:CHEBI:15642, ChEBI:CHEBI:57912, ChEBI:CHEBI:58266, ChEBI:CHEBI:59560; EC=1.14.16.4; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. Expressed in brain. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. monooxygenase activity tryptophan 5-monooxygenase activity iron ion binding serotonin biosynthetic process from tryptophan circadian rhythm aromatic amino acid family metabolic process response to activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen response to nutrient levels serotonin biosynthetic process neuron projection response to estrogen metal ion binding response to glucocorticoid response to calcium ion oxidation-reduction process cellular response to lithium ion uc007haw.1 uc007haw.2 uc007haw.3 
ENSMUST00000006952.9 Saa4 ENSMUST00000006952.9 serum amyloid A 4 (from RefSeq NM_011316.4) ENSMUST00000006952.1 ENSMUST00000006952.2 ENSMUST00000006952.3 ENSMUST00000006952.4 ENSMUST00000006952.5 ENSMUST00000006952.6 ENSMUST00000006952.7 ENSMUST00000006952.8 NM_011316 P31532 SAA4_MOUSE Saa4 Saa5 uc009gyy.1 uc009gyy.2 uc009gyy.3 uc009gyy.4 Major acute phase reactant. Apolipoprotein of the HDL complex. Secreted Expressed by the liver; secreted in plasma. Upon cytokine stimulation. Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Belongs to the SAA family. SAA4 used to be called SAA5. What was SAA4 is a pseudogene which is now called SAA-ps. extracellular region extracellular space acute-phase response high-density lipoprotein particle chemoattractant activity positive chemotaxis cell chemotaxis uc009gyy.1 uc009gyy.2 uc009gyy.3 uc009gyy.4 
ENSMUST00000006956.9 Saa3 ENSMUST00000006956.9 serum amyloid A 3 (from RefSeq NM_011315.3) ENSMUST00000006956.1 ENSMUST00000006956.2 ENSMUST00000006956.3 ENSMUST00000006956.4 ENSMUST00000006956.5 ENSMUST00000006956.6 ENSMUST00000006956.7 ENSMUST00000006956.8 NM_011315 P04918 Q62201 SAA3_MOUSE uc009gyx.1 uc009gyx.2 uc009gyx.3 Major acute phase reactant. Apolipoprotein of the HDL complex. In vitro exhibits antimicrobial activity against Escherichia coli, Streptococcus uberis and Pseudomonas aeruginosa (By similarity). Secreted Found in various tissues. Upon cytokine stimulation. Belongs to the SAA family. extracellular region extracellular space acute-phase response I-kappaB phosphorylation response to bacterium high-density lipoprotein particle response to stilbenoid Toll-like receptor 4 binding chemoattractant activity positive chemotaxis cell chemotaxis cellular response to interleukin-1 uc009gyx.1 uc009gyx.2 uc009gyx.3 
ENSMUST00000006963.3 Krt28 ENSMUST00000006963.3 keratin 28 (from RefSeq NM_027574.2) A6BLY7 ENSMUST00000006963.1 ENSMUST00000006963.2 K1C28_MOUSE Krt25d Krt28 NM_027574 Q9D637 uc007liq.1 uc007liq.2 uc007liq.3 uc007liq.4 Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs). Heterotetramer of two type I and two type II keratins. Cytoplasm In the hair follicle and bulb, uniformly expressed in all three layers of the inner root sheath (the Henle layer, the Huxley layer and the cuticle) and observed in matrix cells (at protein level). There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. structural molecule activity cytoplasm intermediate filament biological_process uc007liq.1 uc007liq.2 uc007liq.3 uc007liq.4 
ENSMUST00000006969.8 Krt23 ENSMUST00000006969.8 keratin 23 (from RefSeq NM_033373.2) ENSMUST00000006969.1 ENSMUST00000006969.2 ENSMUST00000006969.3 ENSMUST00000006969.4 ENSMUST00000006969.5 ENSMUST00000006969.6 ENSMUST00000006969.7 Haik1 K1C23_MOUSE Krt1-23 NM_033373 Q99PS0 uc007liw.1 uc007liw.2 uc007liw.3 Heterotetramer of two type I and two type II keratins. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. structural molecule activity intermediate filament biological_process uc007liw.1 uc007liw.2 uc007liw.3 
ENSMUST00000006973.12 Kat2a ENSMUST00000006973.12 K(lysine) acetyltransferase 2A, transcript variant 3 (from RefSeq NR_166132.1) ENSMUST00000006973.1 ENSMUST00000006973.10 ENSMUST00000006973.11 ENSMUST00000006973.2 ENSMUST00000006973.3 ENSMUST00000006973.4 ENSMUST00000006973.5 ENSMUST00000006973.6 ENSMUST00000006973.7 ENSMUST00000006973.8 ENSMUST00000006973.9 Gcn5l2 Kat2a NR_166132 Q6P3Z8 Q6P3Z8_MOUSE uc007lmb.1 uc007lmb.2 uc007lmb.3 uc007lmb.4 Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Belongs to the acetyltransferase family. GCN5 subfamily. histone acetyltransferase activity nucleus regulation of transcription, DNA-templated N-acetyltransferase activity histone acetylation transferase activity transferase activity, transferring acyl groups uc007lmb.1 uc007lmb.2 uc007lmb.3 uc007lmb.4 
ENSMUST00000006976.8 Odad4 ENSMUST00000006976.8 outer dynein arm complex subunit 4, transcript variant 2 (from RefSeq NM_001363174.1) B8A5X0 B8A5X0_MOUSE ENSMUST00000006976.1 ENSMUST00000006976.2 ENSMUST00000006976.3 ENSMUST00000006976.4 ENSMUST00000006976.5 ENSMUST00000006976.6 ENSMUST00000006976.7 NM_001363174 Odad4 uc011yfb.1 uc011yfb.2 uc011yfb.3 Cytoplasm, cytoskeleton, cilium axoneme uc011yfb.1 uc011yfb.2 uc011yfb.3 
ENSMUST00000006991.9 Hcn1 ENSMUST00000006991.9 hyperpolarization activated cyclic nucleotide gated potassium channel 1 (from RefSeq NM_010408.3) Bcng1 ENSMUST00000006991.1 ENSMUST00000006991.2 ENSMUST00000006991.3 ENSMUST00000006991.4 ENSMUST00000006991.5 ENSMUST00000006991.6 ENSMUST00000006991.7 ENSMUST00000006991.8 HCN1_MOUSE Hac2 NM_010408 O54899 O88704 Q9D613 uc007ryo.1 uc007ryo.2 uc007ryo.3 uc007ryo.4 Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. cAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening. Compared to other family members, cAMP has less stimulatory effect on HCN1 because part of the molecules already contain bound cAMP and form homotetramers when cAMP levels are low. Homotetramer. Heterotetramer with HCN2. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. Interacts with KCNE2. Interacts with the SH3 domain of CSK (PubMed:9405696). O88704; O88704: Hcn1; NbExp=2; IntAct=EBI-8766347, EBI-8766347; Cell membrane ulti-pass membrane protein Predominantly expressed in brain (PubMed:9405696). Highly expressed in apical dendrites of pyramidal neurons in the cortex, in the layer corresponding to the stratum lacunosum-moleculare in the hippocampus and in axons of basket cells in the cerebellum (at protein level) (PubMed:9405696, PubMed:26269648). Expressed in a subset of elongated cells in taste buds (PubMed:11675786). The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. N-glycosylated. Inhibited by extracellular cesium ions. Belongs to the potassium channel HCN family. Sequence=AK014722; Type=Frameshift; Evidence=; nucleotide binding regulation of membrane depolarization ion channel activity intracellular cAMP activated cation channel activity voltage-gated ion channel activity voltage-gated sodium channel activity voltage-gated potassium channel activity potassium channel activity sodium channel activity protein binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm plasma membrane integral component of plasma membrane ion transport potassium ion transport sodium ion transport protein C-terminus binding cell surface membrane integral component of membrane basolateral plasma membrane voltage-gated cation channel activity axon dendrite cAMP binding dendrite membrane regulation of ion transmembrane transport sodium ion transmembrane transport somatodendritic compartment regulation of membrane potential identical protein binding neuronal cell body dendritic shaft axon terminus macromolecular complex binding apical protein localization synapse negative regulation of action potential retinal cone cell development protein homotetramerization response to calcium ion transmembrane transport cellular response to cAMP potassium ion transmembrane transport apical dendrite HCN channel complex regulation of membrane hyperpolarization positive regulation of cation channel activity uc007ryo.1 uc007ryo.2 uc007ryo.3 uc007ryo.4 
ENSMUST00000007005.14 Acat2 ENSMUST00000007005.14 acetyl-Coenzyme A acetyltransferase 2 (from RefSeq NM_009338.3) ENSMUST00000007005.1 ENSMUST00000007005.10 ENSMUST00000007005.11 ENSMUST00000007005.12 ENSMUST00000007005.13 ENSMUST00000007005.2 ENSMUST00000007005.3 ENSMUST00000007005.4 ENSMUST00000007005.5 ENSMUST00000007005.6 ENSMUST00000007005.7 ENSMUST00000007005.8 ENSMUST00000007005.9 NM_009338 Q3TJY7 Q62292 Q8CAY6 Q96EB7 Q99K88 Q9CYV2 THIC_MOUSE uc008alq.1 uc008alq.2 uc008alq.3 Involved in the biosynthetic pathway of cholesterol. Reaction=2 acetyl-CoA = acetoacetyl-CoA + CoA; Xref=Rhea:RHEA:21036, ChEBI:CHEBI:57286, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.9; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21038; Evidence=; Lipid metabolism; fatty acid metabolism. Homotetramer. Cytoplasm, cytosol Belongs to the thiolase-like superfamily. Thiolase family. Sequence=BAB28763.1; Type=Erroneous initiation; Evidence=; catalytic activity acetyl-CoA C-acetyltransferase activity acetyl-CoA C-acyltransferase activity nucleus nucleolus cytoplasm mitochondrion cytosol fatty acid metabolic process fatty acid beta-oxidation transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups positive regulation of intestinal cholesterol absorption uc008alq.1 uc008alq.2 uc008alq.3 
ENSMUST00000007012.6 Sod2 ENSMUST00000007012.6 superoxide dismutase 2, mitochondrial (from RefSeq NM_013671.3) ENSMUST00000007012.1 ENSMUST00000007012.2 ENSMUST00000007012.3 ENSMUST00000007012.4 ENSMUST00000007012.5 NM_013671 Q4FJX9 Q4FJX9_MOUSE Sod2 uc008alv.1 uc008alv.2 uc008alv.3 Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18421; EC=1.15.1.1; Evidence= Homotetramer. Mitochondrion matrix Belongs to the iron/manganese superoxide dismutase family. response to hypoxia DNA binding superoxide dismutase activity cytoplasm mitochondrion superoxide metabolic process response to oxidative stress aging response to radiation response to cold response to manganese ion response to zinc ion response to selenium ion response to activity oxidoreductase activity removal of superoxide radicals oxygen binding enzyme binding manganese ion binding response to nutrient levels response to lipopolysaccharide response to L-ascorbic acid response to silicon dioxide response to isolation stress response to immobilization stress response to drug response to hydrogen peroxide mitochondrial nucleoid hydrogen peroxide metabolic process identical protein binding negative regulation of apoptotic process response to cadmium ion metal ion binding hydrogen peroxide biosynthetic process protein homooligomerization response to electrical stimulus oxidation-reduction process response to magnetism cellular response to ethanol uc008alv.1 uc008alv.2 uc008alv.3 
ENSMUST00000007046.9 Tmco6 ENSMUST00000007046.9 transmembrane and coiled-coil domains 6 (from RefSeq NM_028036.3) ENSMUST00000007046.1 ENSMUST00000007046.2 ENSMUST00000007046.3 ENSMUST00000007046.4 ENSMUST00000007046.5 ENSMUST00000007046.6 ENSMUST00000007046.7 ENSMUST00000007046.8 NM_028036 Q8BQX5 Q99JV8 Q9CWP3 TMCO6_MOUSE uc008eoi.1 uc008eoi.2 uc008eoi.3 uc008eoi.4 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BQX5-1; Sequence=Displayed; Name=2; IsoId=Q8BQX5-2; Sequence=VSP_059937, VSP_059938; [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=BAB26978.1; Type=Frameshift; Evidence=; Sequence=BAC32636.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; cellular_component cell protein import into nucleus biological_process membrane integral component of membrane nuclear import signal receptor activity uc008eoi.1 uc008eoi.2 uc008eoi.3 uc008eoi.4 
ENSMUST00000007130.15 Ctnnb1 ENSMUST00000007130.15 catenin beta 1, transcript variant 1 (from RefSeq NM_007614.3) CTNB1_MOUSE Catnb Ctnnb1 ENSMUST00000007130.1 ENSMUST00000007130.10 ENSMUST00000007130.11 ENSMUST00000007130.12 ENSMUST00000007130.13 ENSMUST00000007130.14 ENSMUST00000007130.2 ENSMUST00000007130.3 ENSMUST00000007130.4 ENSMUST00000007130.5 ENSMUST00000007130.6 ENSMUST00000007130.7 ENSMUST00000007130.8 ENSMUST00000007130.9 NM_007614 Q02248 Q922W1 Q9D335 uc009scu.1 uc009scu.2 uc009scu.3 This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2009]. Key downstream component of the canonical Wnt signaling pathway (PubMed:15132997). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Involved in the regulation of cell adhesion, as component of an E- cadherin:catenin adhesion complex (PubMed:16325582, PubMed:18093941). Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2- mediated sumoylation of PML (By similarity). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (PubMed:21325504). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (PubMed:15132997). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (PubMed:29148101). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (PubMed:29148101). Two separate complex-associated pools are found in the cytoplasm. The majority is present as component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and beta- catenin/CTNNB1, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Binds NHERF1. Interacts with PTPRU (via the cytoplasmic juxtamembrane domain) and with EMD. Interacts with SESTD1 and TRPC4. Interacts with CAV1. Interacts with PTPRJ. Interacts with PKT7. Interacts with FAT1 (via the cytoplasmic domain). Interacts with CDK2, NDRG2 and NANOS1. Interacts with NEK2 and CDK5. Interacts with CARM1, CXADR, PCDH11Y and PTK6. Interacts with RAPGEF2. Interacts with SOX7; this interaction may lead to proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription. Identified in a complex with HINT1 and MITF. Interacts with FHIT. Interacts with FERMT2. Identified in a complex with TCF4 and FERMT2. Another cytoplasmic pool is part of a large complex containing AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. Wnt-dependent activation of DVL antagonizes the action of GSK3B. When GSK3B activity is inhibited the complex dissociates, CTNNB1 is dephosphorylated and is no longer targeted for destruction. The stabilized protein translocates to the nucleus, where it binds TCF/LEF- 1 family members, BCL9, BCL9L and possibly also RUVBL1 and CHD8. Interacts with TAX1BP3 (via the PDZ domain); this interaction inhibits the transcriptional activity of CTNNB1. Interacts with AJAP1, BAIAP1 and CTNNA3. Interacts with TRPV4; the TRPV4 and CTNNB1 complex can interact with CDH1. Interacts with VCL. The CTNNB1 and TCF4 complex interacts with PML. Interacts with XIRP1. Binds CTNNBIP and EP300. CTNNB1 forms a ternary complex with LEF1 and EP300 that is disrupted by CTNNBIP1 binding. Interacts directly with AXIN1; the interaction is regulated by CDK2 phosphorylation of AXIN1. Interacts with GLIS2. Interacts with SCRIB. Interacts with TNIK and TCF7L2. Interacts with SLC30A9. Interacts with RORA. May interact with P-cadherin/CDH3. Interacts with RNF220 (By similarity). Interacts with CTNND2 (By similarity). Interacts (via the C-terminal region) with CBY1 (By similarity). The complex composed, at least, of APC, CTNNB1 and GSK3B interacts with JPT1; the interaction requires the inactive form of GSK3B (phosphorylated at 'Ser-9') (By similarity). Interacts with DLG5 (PubMed:25232112). Interacts with FAM53B; promoting translocation to the nucleus. Interacts with TMEM170B (By similarity). Interacts with AHI1 (By similarity). Interacts with GID8 (By similarity). Component of an cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1 (By similarity). Forms a complex comprising APPL1, RUVBL2, APPL2, HDAC1 and HDAC2 (By similarity). Interacts with IRF2BPL; mediates the ubiquitination and degradation of CTNNB1 (By similarity). Interacts with AMFR (PubMed:31073040). Interacts with LMBR1L (PubMed:31073040). Interacts with SOX30; prevents interaction of CTNNB1 with TCF7L2/TCF4 and leads to inhibition of Wnt signaling (By similarity). Interacts with SOX9; inhibiting CTNNB1 activity by competing with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (PubMed:15132997). Interacts with SPN/CD43 cytoplasmic tail (By similarity). Interacts (when phosphorylated at Tyr-333) with isoform M2 of PKM (PKM2); promoting transcription activation (By similarity). Interacts with PKP2 (via HEAD domain) (By similarity). Interacts with CDH1 (By similarity). Interacts (when unphosphorylated) with FLYWCH1, perhaps preventing interaction of CTNNB1 with TCF4, and thereby regulating transcription activation; phosphorylation of CTNNB1 may inhibit the interaction (By similarity). Interacts (via the central armadillo domains) with probable transcriptional regulator ADNP (via N- terminal region); interaction is direct and stabilizes CTNNB1 by modulating its phosphorylation by glycogen synthase kinase-3 beta GSK3B (PubMed:32533114). Q02248; P09803: Cdh1; NbExp=17; IntAct=EBI-397872, EBI-984420; Q02248; P45481: Crebbp; NbExp=3; IntAct=EBI-397872, EBI-296306; Q02248; P26231: Ctnna1; NbExp=2; IntAct=EBI-397872, EBI-647895; Q02248; Q9WV60: Gsk3b; NbExp=2; IntAct=EBI-397872, EBI-400793; Q02248; P42859: Htt; NbExp=3; IntAct=EBI-397872, EBI-5327353; Q02248; P27782: Lef1; NbExp=6; IntAct=EBI-397872, EBI-984464; Q02248; O54826: Mllt10; NbExp=2; IntAct=EBI-397872, EBI-8459555; Q02248; P97458: Prop1; NbExp=2; IntAct=EBI-397872, EBI-937831; Q02248; Q04207: Rela; NbExp=5; IntAct=EBI-397872, EBI-644400; Q02248; P40645: Sox6; NbExp=2; IntAct=EBI-397872, EBI-3505685; Q02248; Q9DBG9: Tax1bp3; NbExp=6; IntAct=EBI-397872, EBI-1161647; Q02248; P25054: APC; Xeno; NbExp=8; IntAct=EBI-397872, EBI-727707; Q02248; O15169: AXIN1; Xeno; NbExp=5; IntAct=EBI-397872, EBI-710484; Q02248; Q9NSA3: CTNNBIP1; Xeno; NbExp=7; IntAct=EBI-397872, EBI-747082; Q02248; P49841: GSK3B; Xeno; NbExp=3; IntAct=EBI-397872, EBI-373586; Q02248; F1MSG6: RAPGEF2; Xeno; NbExp=2; IntAct=EBI-397872, EBI-6927068; Q02248; O15047: SETD1A; Xeno; NbExp=2; IntAct=EBI-397872, EBI-540779; Q02248; P33148; Xeno; NbExp=4; IntAct=EBI-397872, EBI-15603953; Cytoplasm Nucleus Cytoplasm, cytoskeleton. Cell junction, adherens junction Cell junction Cell membrane Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Synapse Cytoplasm, cytoskeleton, cilium basal body Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is un-stable (highly phosphorylated) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell- cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Interaction with FAM53B promotes translocation to the nucleus (By similarity). Expressed in cerebellar granule neurons (at protein level) (PubMed:21623382). Expressed in the intestinal epithelium (at protein level) (PubMed:22510880). Expressed in bell stage dental mesenchymal cells at 17.5 dpc (at protein level). Phosphorylation at Ser-552 by AMPK promotes stabilization of the protein, enhancing TCF/LEF-mediated transcription (PubMed:20361929). Phosphorylation by GSK3B requires prior phosphorylation of Ser-45 by another kinase (By similarity). Phosphorylation proceeds then from Thr- 41 to Ser-37 and Ser-33 (By similarity). Phosphorylated by NEK2 (By similarity). EGF stimulates tyrosine phosphorylation (By similarity). Phosphorylated on Ser-33 and Ser-37 by HIPK2 and GSK3B, this phosphorylation triggers proteasomal degradation (PubMed:20307497). Phosphorylation on Ser-191 and Ser-246 by CDK5 (By similarity). Phosphorylation by CDK2 regulates insulin internalization (By similarity). Phosphorylation by PTK6 at Tyr-64, Tyr-142, Tyr-331 and/or Tyr-333 with the predominant site at Tyr-64 is not essential for inhibition of transcriptional activity (By similarity). Phosphorylation by SRC at Tyr-333 promotes interaction with isoform M2 of PKM (PKM2); promoting transcription activation (By similarity). Ubiquitinated by the SCF(BTRC) E3 ligase complex when phosphorylated by GSK3B, leading to its degradation (By similarity). Ubiquitinated by a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X, leading to its subsequent proteasomal degradation (By similarity). Ubiquitinated and degraded following interaction with SOX9 (Probable). S-nitrosylation at Cys-619 within adherens junctions promotes VEGF-induced, NO-dependent endothelial cell permeability by disrupting interaction with E-cadherin, thus mediating disassembly adherens junctions. O-glycosylation at Ser-23 decreases nuclear localization and transcriptional activity, and increases localization to the plasma membrane and interaction with E-cadherin CDH1. Deacetylated at Lys-49 by SIRT1. Sympathetic ganglia-specific conditional knockout mice lead to a reduction in sympathetic ganglia size and in progenitor cell number, but does not alter sympathetic innervation of peripheral target organs. Belongs to the beta-catenin family. Sequence=AAH06739.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter protein polyubiquitination embryonic axis specification cell morphogenesis involved in differentiation spindle pole RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding skeletal system development branching involved in blood vessel morphogenesis vasculogenesis branching involved in ureteric bud morphogenesis in utero embryonic development gastrulation with mouth forming second endoderm formation cell fate specification cell fate determination endodermal cell fate commitment neuron migration kidney development neural plate development tissue homeostasis vasculature development positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation lens morphogenesis in camera-type eye ventricular compact myocardium morphogenesis regulation of secondary heart field cardioblast proliferation metanephros morphogenesis negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus transcription factor complex nuclear euchromatin cytoplasm centrosome microtubule organizing center cytosol cytoskeleton plasma membrane cell-cell junction adherens junction cell-cell adherens junction fascia adherens bicellular tight junction cell cortex regulation of transcription from RNA polymerase II promoter cell adhesion cell-matrix adhesion chemical synaptic transmission ectoderm development nervous system development glial cell fate determination heart development protein C-terminus binding transcription factor binding cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation anterior/posterior axis specification dorsal/ventral axis specification dorsal/ventral pattern formation proximal/distal pattern formation cellular process regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of heparan sulfate proteoglycan biosynthetic process Schwann cell proliferation intercalated disc membrane Wnt signaling pathway basolateral plasma membrane lateral plasma membrane morphogenesis of embryonic epithelium catenin complex negative regulation of angiogenesis flotillin complex stem cell population maintenance enzyme binding kinase binding protein kinase binding protein phosphatase binding layer formation in cerebral cortex central nervous system vasculogenesis hair cycle process Z disc lamellipodium cell junction hemopoiesis cell differentiation neuron differentiation T cell differentiation osteoclast differentiation lung development estrogen receptor binding male genitalia development regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation beta-catenin destruction complex forebrain development midbrain development hindbrain development regulation of centriole-centriole cohesion pancreas development hair follicle morphogenesis cell projection membrane microvillus membrane regulation of myelination nuclear membrane positive regulation of telomere maintenance via telomerase negative regulation of chondrocyte differentiation response to estradiol macromolecular complex protein-DNA complex T cell differentiation in thymus negative regulation of protein sumoylation response to cytokine adherens junction organization adherens junction assembly protein localization to cell surface cellular protein localization Scrib-APC-beta-catenin complex embryonic heart tube development genitalia morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis ionotropic glutamate receptor binding nuclear hormone receptor binding embryonic skeletal limb joint morphogenesis regulation of cell proliferation regulation of T cell proliferation odontogenesis of dentin-containing tooth response to drug embryonic digit morphogenesis presynaptic membrane regulation of apoptotic process cell projection positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process dendritic shaft apical junction complex positive regulation of MAPK cascade positive regulation of neuron apoptotic process skin development response to estrogen positive regulation of molecular function ion channel binding canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition nuclear transcription factor complex macromolecular complex binding apical part of cell synapse postsynaptic membrane alpha-catenin binding cadherin binding bone resorption regulation of cell differentiation negative regulation of cell differentiation positive regulation of endothelial cell differentiation regulation of osteoblast differentiation positive regulation of osteoblast differentiation regulation of osteoclast differentiation negative regulation of osteoclast differentiation positive regulation of fibroblast growth factor receptor signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of mitotic cell cycle, embryonic SMAD binding chromatin-mediated maintenance of transcription cell maturation perinuclear region of cytoplasm synaptic vesicle transport animal organ development thymus development oocyte development embryonic foregut morphogenesis positive regulation of skeletal muscle tissue development regulation of smooth muscle cell proliferation negative regulation of oligodendrocyte differentiation negative regulation of neurogenesis synapse organization nitric-oxide synthase binding positive regulation of sequence-specific DNA binding transcription factor activity smooth muscle cell differentiation protein heterooligomerization regulation of histone H3-K4 methylation regulation of anagen positive regulation of telomerase activity cardiac muscle cell proliferation oviduct development canonical Wnt signaling pathway limb development trachea morphogenesis trachea formation epithelial tube branching involved in lung morphogenesis lung cell differentiation lung-associated mesenchyme development mesenchyme development lung induction epithelial cell differentiation involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development hair follicle placode formation mesenchymal cell proliferation involved in lung development cardiac vascular smooth muscle cell differentiation coronary artery morphogenesis epicardium-derived cardiac vascular smooth muscle cell differentiation positive regulation of branching involved in lung morphogenesis endothelial tube morphogenesis fungiform papilla formation canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation sympathetic ganglion development cranial ganglion development beta-catenin-TCF7L2 complex I-SMAD binding repressing transcription factor binding regulation of centromeric sister chromatid cohesion cellular response to mechanical stimulus cellular response to growth factor stimulus cellular response to indole-3-methanol cell periphery renal vesicle formation renal inner medulla development renal outer medulla development nephron tubule formation mesenchyme morphogenesis regulation of nephron tubule epithelial cell differentiation regulation of calcium ion import synaptic vesicle clustering disordered domain specific binding cell-cell adhesion presynaptic active zone cytoplasmic component postsynaptic density, intracellular component negative regulation of neuron death negative regulation of oxidative stress-induced neuron death regulation of histone demethylase activity (H3-K4 specific) regulation of chromatin-mediated maintenance of transcription positive regulation of chromatin-mediated maintenance of transcription regulation of euchromatin binding regulation of core promoter binding positive regulation of core promoter binding cranial skeletal system development midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation neuron projection extension histone methyltransferase binding cellular response to insulin-like growth factor stimulus embryonic brain development dorsal root ganglion development beta-catenin-TCF complex Wnt signalosome regulation of protein localization to cell surface positive regulation of determination of dorsal identity positive regulation of DNA-templated transcription, initiation positive regulation of neural precursor cell proliferation negative regulation of apoptotic signaling pathway neuron projection uc009scu.1 uc009scu.2 uc009scu.3 
ENSMUST00000007139.6 Eif1b ENSMUST00000007139.6 eukaryotic translation initiation factor 1B (from RefSeq NM_026892.3) EIF1B_MOUSE ENSMUST00000007139.1 ENSMUST00000007139.2 ENSMUST00000007139.3 ENSMUST00000007139.4 ENSMUST00000007139.5 NM_026892 Q9CXU9 uc009scp.1 uc009scp.2 uc009scp.3 uc009scp.4 Probably involved in translation. Belongs to the SUI1 family. RNA binding translation initiation factor activity translation translational initiation biological_process eukaryotic 43S preinitiation complex ribosomal small subunit binding uc009scp.1 uc009scp.2 uc009scp.3 uc009scp.4 
ENSMUST00000007156.5 Klk1b11 ENSMUST00000007156.5 kallikrein 1-related peptidase b11 (from RefSeq NM_010640.2) ENSMUST00000007156.1 ENSMUST00000007156.2 ENSMUST00000007156.3 ENSMUST00000007156.4 K1B11_MOUSE Klk-11 Klk11 NM_010640 P15946 uc009goe.1 uc009goe.2 uc009goe.3 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC013660.1, BG865922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Reaction=Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl- bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|- Xaa.; EC=3.4.21.35; Belongs to the peptidase S1 family. Kallikrein subfamily. regulation of systemic arterial blood pressure endopeptidase activity serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides secretory granule zymogen activation macromolecular complex uc009goe.1 uc009goe.2 uc009goe.3 
ENSMUST00000007161.8 Klk4 ENSMUST00000007161.8 kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) (from RefSeq NM_019928.2) EMSP1 ENSMUST00000007161.1 ENSMUST00000007161.2 ENSMUST00000007161.3 ENSMUST00000007161.4 ENSMUST00000007161.5 ENSMUST00000007161.6 ENSMUST00000007161.7 KLK-L1 KLK4_MOUSE Klk4 NM_019928 Prss17 Q9JIS2 Q9Z0M1 uc009gny.1 uc009gny.2 uc009gny.3 Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix. Secreted In developing teeth, expressed in ameloblasts during transition and maturation stages (PubMed:10863090, PubMed:10690663, PubMed:19578120). Expressed weakly in odontoblasts (PubMed:10863090). Not detected in odontoblasts (PubMed:19578120). Detected in the epithelium surrounding the erupted first molar (PubMed:10690663). N-glycosylated. The N-glycan structures are of complex diantennary or triantennary type, which may be further modified with up to 2 sialic acid residues. Viable and fertile, when reared on a soft diet. Tooth morphology is grossly normal but the enamel surface is fragile and rapidly abraded. Although formation of the enamel layer is initially normal, the crystallites fail to thicken and interlock. The enamel proteins enamelin and amelogenin are not cleared and persist in the matrix during the maturation stage. Belongs to the peptidase S1 family. Kallikrein subfamily. serine-type endopeptidase activity extracellular region proteolysis peptidase activity serine-type peptidase activity hydrolase activity extracellular matrix disassembly secretory granule protein catabolic process biomineral tissue development metal ion binding amelogenesis uc009gny.1 uc009gny.2 uc009gny.3 
ENSMUST00000007171.13 Chrd ENSMUST00000007171.13 chordin, transcript variant 6 (from RefSeq NR_184392.1) CHRD_MOUSE ENSMUST00000007171.1 ENSMUST00000007171.10 ENSMUST00000007171.11 ENSMUST00000007171.12 ENSMUST00000007171.2 ENSMUST00000007171.3 ENSMUST00000007171.4 ENSMUST00000007171.5 ENSMUST00000007171.6 ENSMUST00000007171.7 ENSMUST00000007171.8 ENSMUST00000007171.9 NR_184392 Q9Z0E2 uc007yre.1 uc007yre.2 uc007yre.3 Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. Interacts with TWSG1 and/or BMP4. Secreted Detected at high levels in 7 dpc mouse embryos; its level decreases at later developmental stages and in adult tissues. Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development. Belongs to the chordin family. skeletal system development osteoblast differentiation gastrulation with mouth forming second mesoderm formation positive regulation of mesenchymal cell proliferation extracellular region extracellular space multicellular organism development pattern specification process central nervous system development heparin binding dorsal/ventral pattern formation BMP signaling pathway involved in spinal cord dorsal/ventral patterning negative regulation of cell migration negative regulation of BMP signaling pathway forebrain development syndecan binding negative regulation of osteoblast differentiation positive regulation of cell adhesion uc007yre.1 uc007yre.2 uc007yre.3 
ENSMUST00000007207.15 Clcn2 ENSMUST00000007207.15 chloride channel, voltage-sensitive 2, transcript variant 1 (from RefSeq NM_009900.3) CLCN2_MOUSE Clc2 ENSMUST00000007207.1 ENSMUST00000007207.10 ENSMUST00000007207.11 ENSMUST00000007207.12 ENSMUST00000007207.13 ENSMUST00000007207.14 ENSMUST00000007207.2 ENSMUST00000007207.3 ENSMUST00000007207.4 ENSMUST00000007207.5 ENSMUST00000007207.6 ENSMUST00000007207.7 ENSMUST00000007207.8 ENSMUST00000007207.9 NM_009900 Q0VBC2 Q9R0A1 Q9WUJ9 uc012ada.1 uc012ada.2 uc012ada.3 Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport (By similarity). Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (By similarity). Cell membrane ; Multi-pass membrane protein. Expressed in the adrenal gland and brain. Phosphorylated. Activated by dephosphorylation. Hyperpolarization-activated chloride currents are absent in glomerulosa cells of knockout mice. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 2/CLCN2 subfamily. voltage-gated ion channel activity voltage-gated chloride channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport membrane integral component of membrane dendrite regulation of aldosterone biosynthetic process ion transmembrane transport chloride channel complex regulation of ion transmembrane transport perikaryon transmembrane transport retina development in camera-type eye cell differentiation involved in salivary gland development chloride transmembrane transport uc012ada.1 uc012ada.2 uc012ada.3 
ENSMUST00000007212.9 Psmd2 ENSMUST00000007212.9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2, transcript variant 1 (from RefSeq NM_134101.2) ENSMUST00000007212.1 ENSMUST00000007212.2 ENSMUST00000007212.3 ENSMUST00000007212.4 ENSMUST00000007212.5 ENSMUST00000007212.6 ENSMUST00000007212.7 ENSMUST00000007212.8 NM_134101 PSMD2_MOUSE Q8VDM4 uc007yqq.1 uc007yqq.2 uc007yqq.3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2 (By similarity). Interacts with RPGRIP1L (PubMed:26150391). Interacts with CRY1 in a KDM8-dependent manner (PubMed:30500822). Interacts (via C-terminus) with phosphatase UBLCP1 (via ubiquitin-like domain); the interaction recruits UBLCP1 to the 19S regulatory particle where it dephosphorylates 19S subunit PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly (By similarity). Belongs to the proteasome subunit S2 family. proteasome complex protein binding nucleus proteasome regulatory particle proteasome regulatory particle, base subcomplex proteasome accessory complex enzyme regulator activity proteasome storage granule regulation of protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of catalytic activity endopeptidase activity uc007yqq.1 uc007yqq.2 uc007yqq.3 
ENSMUST00000007236.5 Syngr3 ENSMUST00000007236.5 synaptogyrin 3 (from RefSeq NM_011522.3) ENSMUST00000007236.1 ENSMUST00000007236.2 ENSMUST00000007236.3 ENSMUST00000007236.4 NM_011522 Q8R191 Q9WVG8 SNG3_MOUSE Syngr3 uc008axq.1 uc008axq.2 uc008axq.3 May play a role in regulated exocytosis (PubMed:10383386). May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal (PubMed:19357284). Interacts (via N-terminus) with SLC6A3 (via N-terminus) (PubMed:19357284). May interact with VMAT2 (PubMed:19357284). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ulti-pass membrane protein Synapse Note=Found at the neuromuscular synapses. Specifically expressed in brain. Found in the brain across the dorsal and ventral corpus striatum as well as in the cortex. Expression increases during brain development from P2 to adult (at protein level). Belongs to the synaptogyrin family. neurotransmitter uptake protein binding synaptic vesicle membrane integral component of membrane cell junction synaptic vesicle membrane cytoplasmic vesicle neuromuscular junction positive regulation of transporter activity SH2 domain binding regulated exocytosis synapse protein N-terminus binding uc008axq.1 uc008axq.2 uc008axq.3 
ENSMUST00000007245.8 Vwa7 ENSMUST00000007245.8 von Willebrand factor A domain containing 7, transcript variant 1 (from RefSeq NM_138582.1) D17h6s56e-3 ENSMUST00000007245.1 ENSMUST00000007245.2 ENSMUST00000007245.3 ENSMUST00000007245.4 ENSMUST00000007245.5 ENSMUST00000007245.6 ENSMUST00000007245.7 G7c NM_138582 Q9JHA8 Q9Z1Q8 VWA7_MOUSE uc008cfa.1 uc008cfa.2 Secreted Expressed at low level in many tissues. Recombinatorial hotspot within the class III region. Sequence=AAC84152.1; Type=Erroneous gene model prediction; Evidence=; extracellular region uc008cfa.1 uc008cfa.2 
ENSMUST00000007248.5 Hspa1l ENSMUST00000007248.5 heat shock protein 1-like (from RefSeq NM_013558.2) ENSMUST00000007248.1 ENSMUST00000007248.2 ENSMUST00000007248.3 ENSMUST00000007248.4 HS71L_MOUSE Hsc70t NM_013558 O88686 P16627 Q61693 uc008ceq.1 uc008ceq.2 uc008ceq.3 Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria. Interacts with PRKN. Expressed in spermatids. Specifically expressed in postmeiotic phases of spermatogenesis. The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide- binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins. Belongs to the heat shock protein 70 family. nucleotide binding zona pellucida receptor complex ATP binding nucleus cytoplasm cytosol plasma membrane response to unfolded protein multicellular organism development spermatogenesis binding of sperm to zona pellucida COP9 signalosome vesicle-mediated transport ATPase activity cell differentiation heat shock protein binding ubiquitin protein ligase binding macromolecular complex cellular response to heat cellular response to unfolded protein protein refolding ATPase activity, coupled protein binding involved in protein folding cell body unfolded protein binding chaperone mediated protein folding requiring cofactor misfolded protein binding positive regulation of protein targeting to mitochondrion uc008ceq.1 uc008ceq.2 uc008ceq.3 
ENSMUST00000007249.15 Slc44a4 ENSMUST00000007249.15 solute carrier family 44, member 4 (from RefSeq NM_023557.3) CTL4_MOUSE Ctl4 ENSMUST00000007249.1 ENSMUST00000007249.10 ENSMUST00000007249.11 ENSMUST00000007249.12 ENSMUST00000007249.13 ENSMUST00000007249.14 ENSMUST00000007249.2 ENSMUST00000007249.3 ENSMUST00000007249.4 ENSMUST00000007249.5 ENSMUST00000007249.6 ENSMUST00000007249.7 ENSMUST00000007249.8 ENSMUST00000007249.9 NM_023557 Ng22 Q7TQ02 Q91VA1 Q9CVA7 Slc44a4 TPPT1 uc008ceh.1 uc008ceh.2 uc008ceh.3 uc008ceh.4 Choline transporter that plays a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed:24379411). Reaction=choline(out) + n H(+)(in) = choline(in) + n H(+)(out); Xref=Rhea:RHEA:75463, ChEBI:CHEBI:15354, ChEBI:CHEBI:15378; Evidence=; Reaction=thiamine diphosphate(out) = thiamine diphosphate(in); Xref=Rhea:RHEA:75471, ChEBI:CHEBI:58937; Evidence=; Membrane ; Multi- pass membrane protein Apical cell membrane Expressed in colon and cecum. N-glycosylated; N-glycosylation of Asn-67 and Asn-391 is required for a proper thiamine pyrophosphate uptake. Belongs to the CTL (choline transporter-like) family. plasma membrane acetylcholine biosynthetic process choline transmembrane transporter activity choline transport membrane integral component of membrane apical plasma membrane positive regulation of cell growth thiamine pyrophosphate transport otolith formation neuromast hair cell development acetylcholine secretion thiamine pyrophosphate transporter activity uc008ceh.1 uc008ceh.2 uc008ceh.3 uc008ceh.4 
ENSMUST00000007251.14 Abhd16a ENSMUST00000007251.14 abhydrolase domain containing 16A, transcript variant 11 (from RefSeq NR_184561.1) ABHGA_MOUSE Abhd16a Bat5 ENSMUST00000007251.1 ENSMUST00000007251.10 ENSMUST00000007251.11 ENSMUST00000007251.12 ENSMUST00000007251.13 ENSMUST00000007251.2 ENSMUST00000007251.3 ENSMUST00000007251.4 ENSMUST00000007251.5 ENSMUST00000007251.6 ENSMUST00000007251.7 ENSMUST00000007251.8 ENSMUST00000007251.9 NR_184561 Ng26 Q9Z1Q2 uc008cfq.1 uc008cfq.2 Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (PubMed:25580854). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (PubMed:25580854). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914). Reaction=1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphoserine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- heptadecanoyl-sn-glycero-3-phosphoserine + H(+); Xref=Rhea:RHEA:44500, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:84461, ChEBI:CHEBI:84462; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44501; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L- serine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phospho-L-serine + H(+); Xref=Rhea:RHEA:41752, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75020, ChEBI:CHEBI:75029; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41753; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoserine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn- glycero-3-phosphoserine + H(+); Xref=Rhea:RHEA:44516, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:84466, ChEBI:CHEBI:84467; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44517; Evidence=; Reaction=1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- heptadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:44520, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:74340, ChEBI:CHEBI:84470; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44521; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoglycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn- glycero-3-phosphoglycerol + H(+); Xref=Rhea:RHEA:44524, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:84472, ChEBI:CHEBI:84475; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44525; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D- myo-inositol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero- 3-phospho-(1D-myo-inositol) + H(+); Xref=Rhea:RHEA:44528, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72833, ChEBI:CHEBI:72837; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44529; Evidence=; Reaction=1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:44540, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:84489, ChEBI:CHEBI:84490; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44541; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'- sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero- 3-phospho-(1'-sn-glycerol) + H(+); Xref=Rhea:RHEA:40919, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72841, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40920; Evidence=; Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.; EC=3.1.1.23; Evidence=; Reaction=1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate; Xref=Rhea:RHEA:44312, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30807, ChEBI:CHEBI:75562; Evidence=; Reaction=2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:39963, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:75455; Evidence=; Reaction=1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75342; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38491, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:73990; Evidence=; Reaction=2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)- octadecadienoate + glycerol + H(+); Xref=Rhea:RHEA:44732, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30245, ChEBI:CHEBI:75457; Evidence=; Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:44728, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:75612; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence=; Reaction=H2O + prostaglandin D2-1-glycerol ester = glycerol + H(+) + prostaglandin D2; Xref=Rhea:RHEA:45412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:57406, ChEBI:CHEBI:85232; Evidence=; Reaction=11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O = 15-deoxy- Delta(12,14)-prostaglandin J2 + glycerol + H(+); Xref=Rhea:RHEA:45416, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:85236, ChEBI:CHEBI:85238; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45417; Evidence=; Reaction=1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)- octadecadienoate + glycerol + H(+); Xref=Rhea:RHEA:48428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30245, ChEBI:CHEBI:75568; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48429; Evidence=; Specifically inhibited by alpha-alkylidene-beta- lactone KC01 ((Z)-6-(2-Oxo-4-tridecyloxetan-3-ylidene)hexanamide). Kinetic parameters: KM=40 uM for 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoserine ; Vmax=35 nmol/min/mg enzyme with 1-octadecanoyl-2-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phosphoserine as substrate ; Membrane ; Multi- pass membrane protein Mice were born at a much lower frequency than expected and are smaller than wild-type mice throughout development and life (PubMed:25580854). Despite their smaller size, mice appear normal (PubMed:25580854). Metabolomic characterization of brain tissue show decreased lysophosphatidylserines (PubMed:25580854). Belongs to the AB hydrolase superfamily. ABHD16 family. phospholipase activity lipid metabolic process phosphatidylserine catabolic process membrane integral component of membrane hydrolase activity acylglycerol lipase activity monoacylglycerol catabolic process prostaglandin catabolic process uc008cfq.1 uc008cfq.2 
ENSMUST00000007253.6 Neu1 ENSMUST00000007253.6 neuraminidase 1 (from RefSeq NM_010893.3) ENSMUST00000007253.1 ENSMUST00000007253.2 ENSMUST00000007253.3 ENSMUST00000007253.4 ENSMUST00000007253.5 NM_010893 Neu1 Q3UL64 Q3UL64_MOUSE uc008cei.1 uc008cei.2 uc008cei.3 uc008cei.4 Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha- (2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.; EC=3.2.1.18; Evidence=; Interacts with cathepsin A (protective protein), beta- galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex. Cytoplasmic vesicle Lysosome lumen Lysosome membrane ; Peripheral membrane protein ; Lumenal side Belongs to the glycosyl hydrolase 33 family. exo-alpha-sialidase activity lysosome oligosaccharide catabolic process alpha-sialidase activity cell junction intracellular membrane-bounded organelle uc008cei.1 uc008cei.2 uc008cei.3 uc008cei.4 
ENSMUST00000007255.13 Ddah2 ENSMUST00000007255.13 DDAH family member 2, ADMA independent, transcript variant 1 (from RefSeq NM_001190449.1) DDAH2_MOUSE ENSMUST00000007255.1 ENSMUST00000007255.10 ENSMUST00000007255.11 ENSMUST00000007255.12 ENSMUST00000007255.2 ENSMUST00000007255.3 ENSMUST00000007255.4 ENSMUST00000007255.5 ENSMUST00000007255.6 ENSMUST00000007255.7 ENSMUST00000007255.8 ENSMUST00000007255.9 NM_001190449 Q99LD8 uc008cfi.1 uc008cfi.2 uc008cfi.3 uc008cfi.4 Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:37296100, PubMed:21493890). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (PubMed:16574895). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (PubMed:23430976). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055). Cytoplasm Mitochondrion Note=Translocates from cytosol to mitochondrion upon IL1B stimulation in chondrocytes. Mitochondrion Note=(Microbial infection) Translocates to the mitochondrion upon Sendai viral infection. Expressed at high levels in kidney and lung (at protein level) (PubMed:21493890, PubMed:37296100). Expressed in islets of Langerhans (PubMed:23430976). Phosphorylated by TBK1. Phosphorylation inhibits the translocation into the mitochondrion upon Sendai viral infection. Mutant tissues do not show any changes in dimethylarginine dimethylaminohydrolase activity compared to the wild- type littermates. Belongs to the DDAH family. Was originally thought to be a dimethylarginine dimethylaminohydrolase (with EC:3.5.3.18) able to hydrolyze N(G),N(G)- dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA). However, a recent multicentre study have shown that DDAH2 does not have dimethylarginine dimethylaminohydrolase activity by using different approaches. citrulline metabolic process cytoplasm mitochondrion microtubule organizing center cytosol arginine metabolic process arginine catabolic process dimethylargininase activity amino acid binding hydrolase activity positive regulation of nitric oxide biosynthetic process uc008cfi.1 uc008cfi.2 uc008cfi.3 uc008cfi.4 
ENSMUST00000007257.10 Clic1 ENSMUST00000007257.10 chloride intracellular channel 1 (from RefSeq NM_033444.2) CLIC1_MOUSE ENSMUST00000007257.1 ENSMUST00000007257.2 ENSMUST00000007257.3 ENSMUST00000007257.4 ENSMUST00000007257.5 ENSMUST00000007257.6 ENSMUST00000007257.7 ENSMUST00000007257.8 ENSMUST00000007257.9 NM_033444 Q9Z1Q5 uc008cfg.1 uc008cfg.2 uc008cfg.3 Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity). Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts with AKAP9 (By similarity). Nucleus Nucleus membrane ; Single-pass membrane protein Cytoplasm Cell membrane ; Single-pass membrane protein Endoplasmic reticulum Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). Might not be present in the nucleus of cardiac cells (By similarity). Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as a chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity). Belongs to the chloride channel CLIC family. voltage-gated ion channel activity chloride channel activity nucleus nuclear envelope cytoplasm mitochondrion plasma membrane ion transport chloride transport membrane integral component of membrane nuclear membrane ion transmembrane transport chloride channel complex regulation of ion transmembrane transport positive regulation of osteoblast differentiation perinuclear region of cytoplasm regulation of cell cycle regulation of mitochondrial membrane potential extracellular exosome chloride transmembrane transport uc008cfg.1 uc008cfg.2 uc008cfg.3 
ENSMUST00000007259.4 Ly6g6d ENSMUST00000007259.4 lymphocyte antigen 6 family member G6D, transcript variant 1 (from RefSeq NM_033478.3) ENSMUST00000007259.1 ENSMUST00000007259.2 ENSMUST00000007259.3 LY66D_MOUSE NM_033478 Ng25 Q9Z1Q3 uc008cfn.1 uc008cfn.2 uc008cfn.3 Homodimer. Cell membrane ; Lipid-anchor, GPI-anchor Cell projection, filopodium Expressed in embryonic tissue and adult lung, kidney, brain, liver and spleen. O-glycosylated. plasma membrane external side of plasma membrane membrane filopodium acetylcholine receptor inhibitor activity anchored component of membrane macromolecular complex identical protein binding cell projection protein homooligomerization acetylcholine receptor signaling pathway negative regulation of receptor activity uc008cfn.1 uc008cfn.2 uc008cfn.3 
ENSMUST00000007272.8 Krt14 ENSMUST00000007272.8 keratin 14, transcript variant 1 (from RefSeq NM_016958.2) A2A4G4 ENSMUST00000007272.1 ENSMUST00000007272.2 ENSMUST00000007272.3 ENSMUST00000007272.4 ENSMUST00000007272.5 ENSMUST00000007272.6 ENSMUST00000007272.7 K1C14_MOUSE Krt1-14 NM_016958 Q61781 Q91VQ4 Q99LE0 uc007lkp.1 uc007lkp.2 uc007lkp.3 This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. Heterotetramer of two type I and two type II keratins (PubMed:22705788). Forms a disulfide-linked heterodimer (via 2B domains) with KRT5 (via 2B domains) (PubMed:22705788, PubMed:24940650). Forms a heterodimer with KRT1; the interaction is more abundant in the absence of KRT5 (PubMed:11408584). Interacts with PLEC isoform 1C, when in a heterodimer with KRT5 (PubMed:24940650). Interacts with TRADD and with keratin filaments (PubMed:16702408). Associates with other type I keratins (By similarity). Interacts with EPPK1 (PubMed:18285451). Interacts with KLHL24 (By similarity). Interacts with PKP1 (via N- terminus) and PKP2 (By similarity). Cytoplasm Nucleus Note=Expressed in both as a filamentous pattern. Expressed in the corneal epithelium (at protein level) (PubMed:26758872). Expressed in the basal layer of the epidermis and the outer root sheath of hair follicles (at protein level) (PubMed:11408584). Expressed in the epithelial basal layer in the tail epidermis (PubMed:2433272). Expressed in the parabasal cell row, basal cell layer, and suprabasal epithelial layer of the tongue (PubMed:2433272). Expressed in the epithelial cells of the tongue and palate at 17 dpc (PubMed:2433272). Expressed in ameloblasts at the periphery and at the incisal region of mandibular molars at P3 (PubMed:12657653). Expressed at the Tomes' processes of ameloblasts at the incisal region at P5 (PubMed:12657653). Expression at the incisal region decreased at P7 and P9 (PubMed:12657653). A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus. Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex. Increase in CXCL16 abundance in the epidermis at 2 days of age. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. Sequence=AAH03325.1; Type=Erroneous initiation; Evidence=; structural molecule activity protein binding nucleus cytoplasm intermediate filament aging response to zinc ion response to ionizing radiation epithelial cell differentiation hair cycle keratin filament intermediate filament bundle assembly basal part of cell cell periphery keratin filament binding uc007lkp.1 uc007lkp.2 uc007lkp.3 
ENSMUST00000007275.3 Krt13 ENSMUST00000007275.3 keratin 13, transcript variant 1 (from RefSeq NM_010662.2) ENSMUST00000007275.1 ENSMUST00000007275.2 K1C13_MOUSE Krt1-13 NM_010662 P08730 Q3V176 Q6PAI1 uc007lkj.1 uc007lkj.2 uc007lkj.3 uc007lkj.4 The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Type 1 keratin (Probable). Maintains postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially via regulation of the G1/S phase cyclins CCNE1 and CCNE2 (PubMed:32758484). Heterotetramer of two type I and two type II keratins. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P08730-1; Sequence=Displayed; Name=2; IsoId=P08730-2; Sequence=VSP_016378; Expressed in tongue epithelia (at protein level) (PubMed:1695590). Expressed in upper suprabasal layers of the corneal epithelium (at protein level) (PubMed:26758872). Expressed in the oral mucosa, including the palate, dorsal tongue, ventral tongue, and the floor of the mouth at 17.5 dpc (PubMed:32758484). Expressed in basal cells and differentiated keratinocytes at the ventral surface and the oral interpapillary cell column on the dorsal surface of the tongue at birth (PubMed:32758484). Ubiquitously expressed in basal cells and differentiated keratinocytes on the ventral tongue epithelium, however expression was limited to the cells in the interpapillary region and keratinized layer on the dorsal tongue at postnatal day 20 (P20) (PubMed:32758484). Also expressed in the buccal mucosa and esophagus at P20 (PubMed:32758484). O-glycosylated; glycans consist of single N-acetylglucosamine residues. Knockout mice maintain a normal body weight and developmental phenotype (PubMed:32758484). Tongue histological abnormalities are evident at P20 including the loss of two lingual vessel branches at the ventral side of the tongue which appears white and wrinkled, especially on the ventral surface at three weeks of age (PubMed:32758484). Loss of column-like basal cell organization and increase in nuclear atypia and vacuolization in both the basal and suprabasal layers of the tongue (PubMed:32758484). Loss of keratohyalin granules, abnormal presence of cuboidal cells in the suprabasal layers and loss of organization of the outermost keratin layer leading to a foamy appearance (PubMed:32758484). Increase in intracellular gaps, however desmosomes still formed but were found broken and intermediate filaments running from the desmosomes to the cytoplasm were missing or reduced (PubMed:32758484). Cytoplasmic vacuolization is evident in all cell layers and large lipid droplets are found in granular cells in the tongue epithelia (PubMed:32758484). Severe abnormalities in buccal mucosa and esophagus including thickened epithelium, immature suprabasal cells, loss of keratohyalin granules and a disorganized keratin layer at P20 (PubMed:32758484). Disrupted proliferation and differentiation in tongue epithelial cells at P20, as indicated by disordered expression of the transcription factor Tp63/P63, the basal progenitor cell marker Krt5, and the differentiated epithelial cell marker Loricrin (PubMed:32758484). Increase in proliferating cells in the upper layers of the tongue epithelium at P20 (PubMed:32758484). Normal tongue morphology, structural architecture and epithelial cell proliferation at birth (PubMed:32758484). Differential expression of 125 genes in the tongue at P0, enriched in keratinization, proinflammatory responses, stress-activated protein kinase signaling and threonine/lipid metabolic processes (PubMed:32758484). Differential expression of 2907 genes in the ventral tongue at P20 involved in a range of processes, however primarily in cell cycle regulatory pathways (PubMed:32758484). Increase in the expression of CCNE1 and CCNE2 in response to in vitro mechanical stress of the tongue (PubMed:32758484). There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. structural molecule activity protein binding intermediate filament cytoskeleton organization response to radiation tongue morphogenesis keratin filament intermediate filament cytoskeleton extracellular exosome cellular response to retinoic acid uc007lkj.1 uc007lkj.2 uc007lkj.3 uc007lkj.4 
ENSMUST00000007280.9 Krt16 ENSMUST00000007280.9 keratin 16, transcript variant 2 (from RefSeq NM_008470.1) ENSMUST00000007280.1 ENSMUST00000007280.2 ENSMUST00000007280.3 ENSMUST00000007280.4 ENSMUST00000007280.5 ENSMUST00000007280.6 ENSMUST00000007280.7 ENSMUST00000007280.8 K1C16_MOUSE Krt1-16 NM_008470 Q9Z2K1 uc007lkq.1 uc007lkq.2 uc007lkq.3 The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin and acts as an innate immune system effector, promoting the inflammatory response upon breach of the skin barrier. Defects in this gene are a cause of pachyonychia congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Epidermis-specific type I keratin that plays a key role in skin (PubMed:22336941, PubMed:24218583). Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance (PubMed:24218583). Heterodimer of a type I and a type II keratin. KRT16 associates with KRT6 isomers (KRT6A or KRT6B) (PubMed:8636216). Interacts with TCHP (By similarity). Interacts with TRADD (PubMed:16702408). Expressed in the epithelia of the tongue, upper and lower palate, footpad, proximal nail fold and nail bed, penile spine, sweat gland ducts, and back epidermis (at protein level) (PubMed:12445204). Expressed in upper suprabasal layers of the corneal epithelium (at protein level) (PubMed:26758872). Expressed in internal stratified epithelia in the esophagus and vagina (at protein level) (PubMed:12445204). Expressed in transitional stratified squamous epithelia in the forestomach, anal canal, and nasal cavity (at protein level) (PubMed:12445204). Expressed in transitional epithelia of the ureter, bladder and urethra (at protein level) (PubMed:12445204). In mature hair follicles, expressed in the companion layer of the outer root sheath during anagen and in the club hair sheath during catagen and telogen (at protein level) (PubMed:12445204). During embryonic development, initially localizes within early hair germs, but rapidly shifts to a subset of cells at the interface of basal and suprabasal cells above and around the hair germ (PubMed:12445204). Expressed in hair follicles and in most cells in the spinous layer at birth (PubMed:11408584). In response to epidermal stress such as wounding. Mice were born alive at approximately Mendelian ratios but increased postnatal mortality is observed. Surviving mice show oral lesions as well as palmoplantar keratoderma-like hyperkeratotic calluses on front and hind paws, which impair the ability to walk. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. morphogenesis of an epithelium immune system process structural molecule activity structural constituent of cytoskeleton protein binding cytoskeleton intermediate filament inflammatory response aging keratinocyte differentiation negative regulation of cell migration keratinization hair cycle innate immune response intermediate filament cytoskeleton organization keratinocyte migration establishment of skin barrier uc007lkq.1 uc007lkq.2 uc007lkq.3 
ENSMUST00000007296.12 Pole ENSMUST00000007296.12 polymerase (DNA directed), epsilon (from RefSeq NM_011132.2) DPOE1_MOUSE E9QKW1 ENSMUST00000007296.1 ENSMUST00000007296.10 ENSMUST00000007296.11 ENSMUST00000007296.2 ENSMUST00000007296.3 ENSMUST00000007296.4 ENSMUST00000007296.5 ENSMUST00000007296.6 ENSMUST00000007296.7 ENSMUST00000007296.8 ENSMUST00000007296.9 NM_011132 Pole1 Q9QX50 Q9WVF7 uc008yqm.1 uc008yqm.2 uc008yqm.3 uc008yqm.4 Catalytic component of the DNA polymerase epsilon complex (By similarity). Participates in chromosomal DNA replication. Required during synthesis of the leading DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). It is also involved in DNA synthesis during DNA repair (By similarity). Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4. Interacts with RAD17 and TOPBP1. Nucleus. The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for maintenance of the complex. The CysA-type zinc finger is required for PCNA-binding. The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes. Belongs to the DNA polymerase type-B family. G1/S transition of mitotic cell cycle nucleotide binding mitotic cell cycle DNA synthesis involved in DNA repair nucleic acid binding DNA binding chromatin binding DNA-directed DNA polymerase activity nucleus nucleoplasm plasma membrane DNA replication leading strand elongation DNA repair base-excision repair, gap-filling nucleotide-excision repair, DNA gap filling cellular response to DNA damage stimulus zinc ion binding single-stranded DNA 3'-5' exodeoxyribonuclease activity epsilon DNA polymerase complex transferase activity nucleotidyltransferase activity DNA replication proofreading metal ion binding embryonic organ development iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding DNA biosynthetic process nucleic acid phosphodiester bond hydrolysis uc008yqm.1 uc008yqm.2 uc008yqm.3 uc008yqm.4 
ENSMUST00000007317.8 Krt19 ENSMUST00000007317.8 keratin 19, transcript variant 1 (from RefSeq NM_008471.3) ENSMUST00000007317.1 ENSMUST00000007317.2 ENSMUST00000007317.3 ENSMUST00000007317.4 ENSMUST00000007317.5 ENSMUST00000007317.6 ENSMUST00000007317.7 K1C19_MOUSE Krt1-19 NM_008471 P19001 uc007lkm.1 uc007lkm.2 uc007lkm.3 uc007lkm.4 uc007lkm.5 uc007lkm.6 The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity). Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD (By similarity). Expressed throughout embryonic development with highest levels at 8.5 dpc. Expression decreases by 11.5 dpc and increases again by 17.5 dpc. This keratin differs from all other IF proteins in lacking the C-terminal tail domain. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. structural molecule activity protein binding intermediate filament plasma membrane Notch signaling pathway structural constituent of muscle dystrophin-associated glycoprotein complex apicolateral plasma membrane Z disc sarcolemma costamere response to estrogen macromolecular complex binding sarcomere organization cell differentiation involved in embryonic placenta development cell periphery terminal web uc007lkm.1 uc007lkm.2 uc007lkm.3 uc007lkm.4 uc007lkm.5 uc007lkm.6 
ENSMUST00000007318.2 Krt31 ENSMUST00000007318.2 keratin 31 (from RefSeq NM_010659.2) A2A5Y0 ENSMUST00000007318.1 Hka1 K1H1_MOUSE Krt1-1 Krtha1 NM_010659 Q61765 uc007lkd.1 uc007lkd.2 There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). Belongs to the intermediate filament family. structural molecule activity intermediate filament uc007lkd.1 uc007lkd.2 
ENSMUST00000007340.4 Atp12a ENSMUST00000007340.4 ATPase, H+/K+ transporting, nongastric, alpha polypeptide (from RefSeq NM_138652.2) AT12A_MOUSE Atp1al1 ENSMUST00000007340.1 ENSMUST00000007340.2 ENSMUST00000007340.3 NM_138652 Q32MR8 Q8VHY2 Q9Z1W8 uc007ubw.1 uc007ubw.2 uc007ubw.3 uc007ubw.4 The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (By similarity). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (PubMed:9449685). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (By similarity). Reaction=ATP + H(+)(in) + H2O + K(+)(out) = ADP + 2 H(+)(out) + K(+)(in) + phosphate; Xref=Rhea:RHEA:22044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.19; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22045; Evidence=; Reaction=ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate; Xref=Rhea:RHEA:18353, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18354; Evidence=; The ATPase pump is composed of a catalytic alpha subunit and an auxiliary non-catalytic beta subunit. The alpha subunit pairs with the beta subunit of gastric H(+)/K(+) ATPase ATP4B or the beta subunit of Na(+)/K(+) ATPases ATP1B1 and ATP1B3; this interaction is required for the formation of a functionally active pump and its targeting at the plasma membrane. Apical cell membrane ; Multi- pass membrane protein Found in skin, kidney and distal colon. Up-regulated in kidney and down-regulated in colon in response to K(+) ion free diet. Mice are born at the expected Mendelian rate. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. nucleotide binding sodium:potassium-exchanging ATPase activity protein binding ATP binding plasma membrane ion transport potassium ion transport cellular sodium ion homeostasis regulation of pH potassium-transporting ATPase activity hydrogen:potassium-exchanging ATPase activity response to metal ion establishment or maintenance of transmembrane electrochemical gradient response to organic cyclic compound membrane integral component of membrane basolateral plasma membrane apical plasma membrane cation-transporting ATPase activity cellular potassium ion homeostasis sodium ion export from cell metal ion binding potassium ion homeostasis potassium ion import across plasma membrane uc007ubw.1 uc007ubw.2 uc007ubw.3 uc007ubw.4 
ENSMUST00000007444.14 Strada ENSMUST00000007444.14 STE20-related kinase adaptor alpha, transcript variant 1 (from RefSeq NM_001252448.2) ENSMUST00000007444.1 ENSMUST00000007444.10 ENSMUST00000007444.11 ENSMUST00000007444.12 ENSMUST00000007444.13 ENSMUST00000007444.2 ENSMUST00000007444.3 ENSMUST00000007444.4 ENSMUST00000007444.5 ENSMUST00000007444.6 ENSMUST00000007444.7 ENSMUST00000007444.8 ENSMUST00000007444.9 Lyk5 NM_001252448 Q3UUJ4 Q6VEU7 Q9D0G8 STRAA_MOUSE Strad uc007lyg.1 uc007lyg.2 uc007lyg.3 uc007lyg.4 Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q3UUJ4-1; Sequence=Displayed; Name=2 ; IsoId=Q3UUJ4-2; Sequence=VSP_052217, VSP_052218; Name=3 ; IsoId=Q3UUJ4-3; Sequence=VSP_052217; The protein kinase domain is predicted to be catalytically inactive. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol protein phosphorylation protein export from nucleus cell cycle kinase binding signal transduction by protein phosphorylation protein kinase activator activity activation of protein kinase activity macromolecular complex protein serine/threonine kinase activator activity protein heterooligomerization positive regulation of protein serine/threonine kinase activity uc007lyg.1 uc007lyg.2 uc007lyg.3 uc007lyg.4 
ENSMUST00000007449.9 Akr1b7 ENSMUST00000007449.9 aldo-keto reductase family 1, member B7 (from RefSeq NM_009731.2) Akr1b7 ENSMUST00000007449.1 ENSMUST00000007449.2 ENSMUST00000007449.3 ENSMUST00000007449.4 ENSMUST00000007449.5 ENSMUST00000007449.6 ENSMUST00000007449.7 ENSMUST00000007449.8 NM_009731 Q5M9J9 Q5M9J9_MOUSE uc009bhd.1 uc009bhd.2 uc009bhd.3 uc009bhd.4 Belongs to the aldo/keto reductase family. oxidoreductase activity oxidation-reduction process uc009bhd.1 uc009bhd.2 uc009bhd.3 uc009bhd.4 
ENSMUST00000007482.8 Mrpl49 ENSMUST00000007482.8 mitochondrial ribosomal protein L49 (from RefSeq NM_026246.4) ENSMUST00000007482.1 ENSMUST00000007482.2 ENSMUST00000007482.3 ENSMUST00000007482.4 ENSMUST00000007482.5 ENSMUST00000007482.6 ENSMUST00000007482.7 NM_026246 Q3UC21 Q8C5R0 Q8C7P3 Q9CQ40 RM49_MOUSE uc008ggq.1 uc008ggq.2 uc008ggq.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity). Interacts with OXA1L (By similarity). Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mL49 family. structural constituent of ribosome mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit ribosome translation biological_process uc008ggq.1 uc008ggq.2 uc008ggq.3 
ENSMUST00000007559.15 Gatad1 ENSMUST00000007559.15 GATA zinc finger domain containing 1 (from RefSeq NM_026033.2) ENSMUST00000007559.1 ENSMUST00000007559.10 ENSMUST00000007559.11 ENSMUST00000007559.12 ENSMUST00000007559.13 ENSMUST00000007559.14 ENSMUST00000007559.2 ENSMUST00000007559.3 ENSMUST00000007559.4 ENSMUST00000007559.5 ENSMUST00000007559.6 ENSMUST00000007559.7 ENSMUST00000007559.8 ENSMUST00000007559.9 GATD1_MOUSE NM_026033 Odag Q8VCQ2 Q920S3 Q9CSG2 uc008whh.1 uc008whh.2 uc008whh.3 uc008whh.4 Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). Component of a chromatin complex, at least composed of KDM5A, GATAD1 and EMSY. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q920S3-1; Sequence=Displayed; Name=2; IsoId=Q920S3-2; Sequence=VSP_025823, VSP_025824; Expressed in the eye (lens, ciliary body, retina, sclera and conjunctiva) at postnatal day 2 and 10. Not detected anywhere at postnatal day 14. Expressed in embryo at 13 dpc onwards. Expressed in embryonic heart at all stages of development. Sequence=BAB28550.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; nucleus nucleoplasm regulation of transcription, DNA-templated zinc ion binding chromatin assembly sequence-specific DNA binding metal ion binding uc008whh.1 uc008whh.2 uc008whh.3 uc008whh.4 
ENSMUST00000007584.4 Pcdhac1 ENSMUST00000007584.4 protocadherin alpha subfamily C, 1 (from RefSeq NM_001003671.1) ENSMUST00000007584.1 ENSMUST00000007584.2 ENSMUST00000007584.3 NM_001003671 Pcdhac1 Q91Y10 Q91Y10_MOUSE uc008epj.1 uc008epj.2 uc008epj.3 uc008epj.4 uc008epj.5 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epj.1 uc008epj.2 uc008epj.3 uc008epj.4 uc008epj.5 
ENSMUST00000007601.4 2310003L06Rik ENSMUST00000007601.4 2310003L06Rik (from geneSymbol) 2310003L06Rik AK009122 ENSMUST00000007601.1 ENSMUST00000007601.2 ENSMUST00000007601.3 Q9CV82 Q9CV82_MOUSE uc290wwe.1 uc290wwe.2 molecular_function cellular_component biological_process uc290wwe.1 uc290wwe.2 
ENSMUST00000007708.14 Ppp2r1a ENSMUST00000007708.14 protein phosphatase 2, regulatory subunit A, alpha (from RefSeq NM_016891.3) 2AAA_MOUSE ENSMUST00000007708.1 ENSMUST00000007708.10 ENSMUST00000007708.11 ENSMUST00000007708.12 ENSMUST00000007708.13 ENSMUST00000007708.2 ENSMUST00000007708.3 ENSMUST00000007708.4 ENSMUST00000007708.5 ENSMUST00000007708.6 ENSMUST00000007708.7 ENSMUST00000007708.8 ENSMUST00000007708.9 NM_016891 Q76MZ3 uc008aqi.1 uc008aqi.2 uc008aqi.3 The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:10100624, PubMed:26974206). Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (PubMed:26974206, PubMed:33505023). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (PubMed:33505023). PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with FOXO1; the interaction dephosphorylates FOXO1 on AKT-mediated phosphorylation sites (PubMed:22417654). Interacts with IPO9 (By similarity). Interacts with TP53 and SGO1 (By similarity). Interacts with PLA2G16; this interaction might decrease PP2A activity (By similarity). Interacts with CTTNBP2NL (By similarity). Interacts with GNA12; the interaction promotes protein phosphatase 2A activation causing dephosphorylation of MAPT (By similarity).Interacts with CIP2A; this interaction stabilizes CIP2A (By similarity). Interacts with PABIR1/FAM122A (By similarity). Interacts with ADCY8; antagonizes interaction between ADCY8 and calmodulin (PubMed:16258073). Interacts with CRTC3 (when phosphorylated at 'Ser-391') (PubMed:30611118). Interacts with SPRY2 (By similarity). Q76MZ3; P63330: Ppp2ca; NbExp=3; IntAct=EBI-400413, EBI-397144; Q76MZ3; O56327; Xeno; NbExp=2; IntAct=EBI-400413, EBI-15646000; Cytoplasm Nucleus Chromosome, centromere Lateral cell membrane Cell projection, dendrite Note=Centromeric localization requires the presence of BUB1. Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure. Belongs to the phosphatase 2A regulatory subunit A family. protein phosphatase type 2A complex chromosome, centromeric region protein serine/threonine phosphatase activity protein binding nucleus chromosome cytoplasm cytosol plasma membrane chromosome segregation female meiotic division membrane lateral plasma membrane protein phosphatase regulator activity dendrite cell projection regulation of phosphoprotein phosphatase activity synapse protein heterodimerization activity meiotic spindle elongation mitotic sister chromatid separation meiotic sister chromatid cohesion, centromeric macromolecular complex assembly peptidyl-serine dephosphorylation glutamatergic synapse regulation of meiotic cell cycle process involved in oocyte maturation protein antigen binding positive regulation of extrinsic apoptotic signaling pathway in absence of ligand uc008aqi.1 uc008aqi.2 uc008aqi.3 
ENSMUST00000007733.8 Tinf2 ENSMUST00000007733.8 Terf1 (TRF1)-interacting nuclear factor 2, transcript variant 3 (from RefSeq NM_145705.4) ENSMUST00000007733.1 ENSMUST00000007733.2 ENSMUST00000007733.3 ENSMUST00000007733.4 ENSMUST00000007733.5 ENSMUST00000007733.6 ENSMUST00000007733.7 NM_145705 Q8K1K3 Q8K1K3_MOUSE Tinf2 uc007uaf.1 uc007uaf.2 uc007uaf.3 uc007uaf.4 uc007uaf.5 chromosome, telomeric region nuclear telomere cap complex nuclear chromosome, telomeric region perinucleolar chromocenter negative regulation of protein ADP-ribosylation telomere capping nuclear body telomere assembly negative regulation of telomere maintenance via telomerase telomeric DNA binding negative regulation of epithelial cell proliferation telosome protein localization to chromosome, telomeric region regulation of telomere maintenance via telomere lengthening uc007uaf.1 uc007uaf.2 uc007uaf.3 uc007uaf.4 uc007uaf.5 
ENSMUST00000007738.11 Hapln4 ENSMUST00000007738.11 hyaluronan and proteoglycan link protein 4 (from RefSeq NM_177900.4) Bral2 ENSMUST00000007738.1 ENSMUST00000007738.10 ENSMUST00000007738.2 ENSMUST00000007738.3 ENSMUST00000007738.4 ENSMUST00000007738.5 ENSMUST00000007738.6 ENSMUST00000007738.7 ENSMUST00000007738.8 ENSMUST00000007738.9 HPLN4_MOUSE Lpr4 NM_177900 Q05AB1 Q80WM4 Q80XX2 uc009lyr.1 uc009lyr.2 uc009lyr.3 Essential for the proper localization of brevican (BCAN), mainly as a perineuronal nets (PNNs)-type deposition in the brainstem and cerebellum thereby playing a key role in the formation and structural organization of PNNs (PubMed:22121037). Contributes to the formation and transmission of inhibitory GABAergic synapses between Purkinje cells and deep cerebellar nuclei neurons (PubMed:30125937). Secreted, extracellular space, extracellular matrix Expressed predominantly in brain where it is found mainly throughout the midbrain and hindbrain in a perineuronal net pattern. Expression begins at embryonic day 20 and increases thereafter. Expression continues into adulthood. In deep cerebellar nuclei (DCN) neurons of knockout mice, inhibitory synaptic strengths are reduced as compared to those in wild-type mice, whereas the properties of excitatory synapses are unaffected (PubMed:30125937). A reduction in GABAergic pre-synaptic terminals of Purkinje cells are seen in the DCN neurons (PubMed:30125937). Mice show significantly attenuated perineuronal nets formation in the DCN, a marked decrease of brevican (BCAN) in the brainstem and cerebellum and a reduction in synapse number in the DCN neurons (PubMed:22121037). Belongs to the HAPLN family. skeletal system development hyaluronic acid binding extracellular region cell adhesion central nervous system development extracellular matrix uc009lyr.1 uc009lyr.2 uc009lyr.3 
ENSMUST00000007747.10 Dus3l ENSMUST00000007747.10 dihydrouridine synthase 3 like, transcript variant 1 (from RefSeq NM_144858.2) A0A0R4IZY9 A0A0R4IZY9_MOUSE Dus3l ENSMUST00000007747.1 ENSMUST00000007747.2 ENSMUST00000007747.3 ENSMUST00000007747.4 ENSMUST00000007747.5 ENSMUST00000007747.6 ENSMUST00000007747.7 ENSMUST00000007747.8 ENSMUST00000007747.9 NM_144858 uc008ddd.1 uc008ddd.2 uc008ddd.3 uc008ddd.4 Reaction=5,6-dihydrouridine(47) in tRNA + NAD(+) = H(+) + NADH + uridine(47) in tRNA; Xref=Rhea:RHEA:53364, Rhea:RHEA-COMP:13539, Rhea:RHEA-COMP:13540, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:65315, ChEBI:CHEBI:74443; EC=1.3.1.89; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:53366; Evidence=; Reaction=5,6-dihydrouridine(47) in tRNA + NADP(+) = H(+) + NADPH + uridine(47) in tRNA; Xref=Rhea:RHEA:53360, Rhea:RHEA-COMP:13539, Rhea:RHEA-COMP:13540, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:65315, ChEBI:CHEBI:74443; EC=1.3.1.89; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:53362; Evidence=; Reaction=a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + H(+) + NADH; Xref=Rhea:RHEA:69851, Rhea:RHEA-COMP:14658, Rhea:RHEA- COMP:17789, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:65315, ChEBI:CHEBI:74443; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:69853; Evidence=; Reaction=a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + H(+) + NADPH; Xref=Rhea:RHEA:69855, Rhea:RHEA-COMP:14658, Rhea:RHEA- COMP:17789, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:65315, ChEBI:CHEBI:74443; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:69857; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence= Belongs to the dus family. Dus3 subfamily. tRNA dihydrouridine synthesis catalytic activity tRNA processing oxidoreductase activity tRNA dihydrouridine synthase activity metal ion binding flavin adenine dinucleotide binding oxidation-reduction process uc008ddd.1 uc008ddd.2 uc008ddd.3 uc008ddd.4 
ENSMUST00000007754.13 Gtpbp3 ENSMUST00000007754.13 GTP binding protein 3, transcript variant 1 (from RefSeq NM_032544.4) ENSMUST00000007754.1 ENSMUST00000007754.10 ENSMUST00000007754.11 ENSMUST00000007754.12 ENSMUST00000007754.2 ENSMUST00000007754.3 ENSMUST00000007754.4 ENSMUST00000007754.5 ENSMUST00000007754.6 ENSMUST00000007754.7 ENSMUST00000007754.8 ENSMUST00000007754.9 GTPB3_MOUSE NM_032544 Q58E73 Q923K4 Q99M99 uc009mdn.1 uc009mdn.2 GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q923K4-1; Sequence=Displayed; Name=2; IsoId=Q923K4-2; Sequence=VSP_023585, VSP_023586; Ubiquitously expressed. Highly expressed in tissues with high metabolic rates including heart, liver and brain. Weakly expressed in skeletal muscle. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. nucleotide binding tRNA wobble uridine modification GTPase activity GTP binding nucleus cytoplasm mitochondrion tRNA modification tRNA processing tRNA methylation embryonic organ development uc009mdn.1 uc009mdn.2 
ENSMUST00000007757.15 Tgfbr1 ENSMUST00000007757.15 transforming growth factor, beta receptor I, transcript variant 1 (from RefSeq NM_009370.4) A2AJN0 ENSMUST00000007757.1 ENSMUST00000007757.10 ENSMUST00000007757.11 ENSMUST00000007757.12 ENSMUST00000007757.13 ENSMUST00000007757.14 ENSMUST00000007757.2 ENSMUST00000007757.3 ENSMUST00000007757.4 ENSMUST00000007757.5 ENSMUST00000007757.6 ENSMUST00000007757.7 ENSMUST00000007757.8 ENSMUST00000007757.9 NM_009370 Q64729 TGFR1_MOUSE uc008sun.1 uc008sun.2 uc008sun.3 uc008sun.4 This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity). Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA- COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Kept in an inactive conformation by FKBP1A preventing receptor activation in absence of ligand. CD109 is another inhibitor of the receptor (By similarity). Homodimer; in the endoplasmic reticulum but also at the cell membrane. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGBRB1 and TGFBR2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Component of a complex composed of TSC22D1 (via N-terminus), TGFBR1 and TGFBR2; the interaction between TSC22D1 and TGFBR1 is inhibited by SMAD7 and promoted by TGFB1 (By similarity). Interacts with CD109; inhibits TGF-beta receptor activation in keratinocytes. Interacts with RBPMS. Interacts (unphosphorylated) with FKBP1A; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation. Interacts with SMAD2, SMAD3 and ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF- beta receptor. Interacts with TRAF6 and MAP3K7; induces MAP3K7 activation by TRAF6. Interacts with PARD6A; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with NEDD4L (By similarity). Interacts with SMAD7, SMURF1 and SMURF2; SMAD7 recruits NEDD4L, SMURF1 and SMURF2 to the TGF-beta receptor (By similarity). Interacts with USP15 and VPS39. Interacts with SDCBP (via C-terminus) (By similarity). Interacts with CAV1 and this interaction is impaired in the presence of SDCBP (By similarity). Interacts with APPL1; interaction is TGF beta dependent; mediates trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (By similarity). Interacts with GPR50; this interaction promotes the constitutive activation of SMAD signaling pathway (By similarity). Q64729; Q9DBG3: Ap2b1; NbExp=2; IntAct=EBI-2899393, EBI-775229; Q64729; P49817: Cav1; NbExp=4; IntAct=EBI-2899393, EBI-1161338; Q64729; P15379: Cd44; NbExp=4; IntAct=EBI-2899393, EBI-7565891; Q64729; P55284: Cdh5; NbExp=2; IntAct=EBI-2899393, EBI-7087433; Q64729; P05533: Ly6a; NbExp=2; IntAct=EBI-2899393, EBI-11600492; Q64729; P98083-2: Shc1; NbExp=7; IntAct=EBI-2899393, EBI-1019301; Q64729; Q62312: Tgfbr2; NbExp=3; IntAct=EBI-2899393, EBI-2899332; Q64729; P63010: AP2B1; Xeno; NbExp=3; IntAct=EBI-2899393, EBI-432924; Q64729; Q8TDM6: DLG5; Xeno; NbExp=3; IntAct=EBI-2899393, EBI-715138; Q64729; P84022: SMAD3; Xeno; NbExp=6; IntAct=EBI-2899393, EBI-347161; Cell membrane ; Single-pass type I membrane protein Cell junction, tight junction Membrane raft Cell surface Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q64729-1; Sequence=Displayed; Name=2; IsoId=Q64729-2; Sequence=VSP_021593; Phosphorylated at basal levels in the absence of ligand. Activated upon phosphorylation by TGFBR2, mainly in the GS domain. Phosphorylation in the GS domain abrogates FKBP1A-binding (By similarity). N-Glycosylated. Ubiquitinated; undergoes ubiquitination catalyzed by several E3 ubiquitin ligases including SMURF1, SMURF2 and NEDD4L2. Results in the proteasomal and/or lysosomal degradation of the receptor thereby negatively regulating its activity. Deubiquitinated by USP15, leading to stabilization of the protein and enhanced TGF-beta signal. Its ubiquitination and proteasome-mediated degradation is negatively regulated by SDCBP (By similarity). [Isoform 2]: May be due to a competing donor splice site. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. nucleotide binding activation of MAPKK activity skeletal system development angiogenesis in utero embryonic development kidney development blastocyst development epithelial to mesenchymal transition negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation lens development in camera-type eye ventricular trabecula myocardium morphogenesis ventricular compact myocardium morphogenesis protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I receptor binding type II transforming growth factor beta receptor binding protein binding ATP binding cell nucleus endosome plasma membrane integral component of plasma membrane caveola bicellular tight junction regulation of transcription, DNA-templated protein phosphorylation apoptotic process signal transduction transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway pattern specification process heart development positive regulation of cell proliferation germ cell migration male gonad development post-embryonic development anterior/posterior pattern specification cell surface regulation of gene expression positive regulation of gene expression regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation membrane integral component of membrane kinase activity phosphorylation basolateral plasma membrane apical plasma membrane transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation growth factor binding cell junction cell differentiation collagen fibril organization positive regulation of cell growth positive regulation of cell migration regulation of protein ubiquitination ubiquitin protein ligase binding negative regulation of chondrocyte differentiation activin receptor signaling pathway macromolecular complex intracellular signal transduction regulation of growth endothelial cell activation positive regulation of apoptotic process negative regulation of apoptotic process intracellular membrane-bounded organelle receptor complex regulation of protein binding endothelial cell migration response to estrogen macromolecular complex binding membrane raft negative regulation of endothelial cell differentiation positive regulation of transcription, DNA-templated SMAD binding protein autophosphorylation metal ion binding protein heterodimerization activity activin receptor complex activin binding thymus development neuron fate commitment embryonic cranial skeleton morphogenesis skeletal system morphogenesis mesenchymal cell differentiation artery morphogenesis cell motility transforming growth factor beta binding positive regulation of cellular component movement positive regulation of filopodium assembly positive regulation of stress fiber assembly positive regulation of protein kinase B signaling parathyroid gland development palate development pharyngeal system development regulation of cardiac muscle cell proliferation cardiac epithelial to mesenchymal transition pathway-restricted SMAD protein phosphorylation positive regulation of SMAD protein import into nucleus ventricular septum morphogenesis angiogenesis involved in coronary vascular morphogenesis coronary artery morphogenesis I-SMAD binding response to cholesterol cellular response to transforming growth factor beta stimulus negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of occluding junction disassembly epicardium morphogenesis positive regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway proepicardium development uc008sun.1 uc008sun.2 uc008sun.3 uc008sun.4 
ENSMUST00000007797.10 Gabrb2 ENSMUST00000007797.10 gamma-aminobutyric acid type A receptor subunit beta 2, transcript variant 2 (from RefSeq NM_008070.5) A6H6R7 D1LYT3 ENSMUST00000007797.1 ENSMUST00000007797.2 ENSMUST00000007797.3 ENSMUST00000007797.4 ENSMUST00000007797.5 ENSMUST00000007797.6 ENSMUST00000007797.7 ENSMUST00000007797.8 ENSMUST00000007797.9 GBRB2_MOUSE Gabrb-2 NM_008070 P15432 P63137 uc007imi.1 uc007imi.2 uc007imi.3 Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:20400944). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:27129275). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275). The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (PubMed:27129275). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Allosterically activated by benzodiazepines and the anesthetic etomidate (By similarity). Inhibited by the antagonist bicuculline (By similarity). Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (By similarity). Interacts with UBQLN1 (By similarity). Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (PubMed:20400944). May interact with KIF21B (By similarity). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Postsynaptic cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=P63137-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P63137-2; Sequence=VSP_038829; The extracellular domain contributes to synaptic contact formation. Glycosylated. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub- subfamily. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity inhibitory extracellular ligand-gated ion channel activity chloride channel activity protein binding cytosol plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction gamma-aminobutyric acid signaling pathway chemical synaptic transmission sensory perception of sound membrane integral component of membrane GABA receptor activity GABA-gated chloride ion channel activity cell junction cytoplasmic vesicle ion transmembrane transport chloride channel complex regulation of membrane potential neuron projection regulation of neuron apoptotic process negative regulation of neuron apoptotic process synapse postsynaptic membrane neuron development neurological system process synaptic transmission, GABAergic regulation of postsynaptic membrane potential inner ear receptor cell development innervation cellular response to histamine cochlea development GABA-ergic synapse integral component of postsynaptic specialization membrane negative regulation of neuron death chloride transmembrane transport GABA receptor complex GABA-A receptor complex transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential inhibitory synapse assembly uc007imi.1 uc007imi.2 uc007imi.3 
ENSMUST00000007799.13 Cav1 ENSMUST00000007799.13 caveolin 1, caveolae protein, transcript variant 1 (from RefSeq NM_007616.5) CAV1_MOUSE Cav ENSMUST00000007799.1 ENSMUST00000007799.10 ENSMUST00000007799.11 ENSMUST00000007799.12 ENSMUST00000007799.2 ENSMUST00000007799.3 ENSMUST00000007799.4 ENSMUST00000007799.5 ENSMUST00000007799.6 ENSMUST00000007799.7 ENSMUST00000007799.8 ENSMUST00000007799.9 NM_007616 P49817 Q8C1X7 Q8CBP4 Q9QYH3 Q9QYH4 uc009azo.1 uc009azo.2 uc009azo.3 uc009azo.4 May act as a scaffolding protein within caveolar membranes (By similarity). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19546242). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (PubMed:10816572). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity). Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1 (By similarity). Interacts with CTNNB1, CDH1 and JUP. Interacts with PACSIN2; this interaction induces membrane tubulation (PubMed:21610094). Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with EHD2 in a cholesterol-dependent manner (By similarity). Interacts with CAVIN1 (PubMed:19546242). Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation (By similarity). Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (PubMed:16877379). P49817; P15208: Insr; NbExp=2; IntAct=EBI-1161338, EBI-6999015; P49817; Q64729: Tgfbr1; NbExp=4; IntAct=EBI-1161338, EBI-2899393; P49817; Q07820: MCL1; Xeno; NbExp=3; IntAct=EBI-1161338, EBI-1003422; P49817; P22307: SCP2; Xeno; NbExp=3; IntAct=EBI-1161338, EBI-1050999; Golgi apparatus membrane ; Peripheral membrane protein Cell membrane ; Peripheral membrane protein Membrane, caveola ; Peripheral membrane protein Membrane raft Golgi apparatus, trans-Golgi network Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=P49817-1; Sequence=Displayed; Name=2; IsoId=P49817-2; Sequence=VSP_018693; Adipose tissue, lung, heart, skeletal muscle, stomach, small bowel, kidney, spleen and testis (at protein level). The N-terminus of both isoforms are blocked. Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress. Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response. Belongs to the caveolin family. negative regulation of transcription from RNA polymerase II promoter Golgi membrane SNARE binding inactivation of MAPK activity angiogenesis vasculogenesis response to hypoxia negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation negative regulation of cytokine-mediated signaling pathway regulation of the force of heart contraction acrosomal membrane caveolar macromolecular signaling complex response to ischemia regulation of the force of heart contraction by chemical signal receptor binding protein binding cytoplasm mitochondrion endosome peroxisomal membrane endoplasmic reticulum Golgi apparatus lipid particle cytosol plasma membrane integral component of plasma membrane caveola focal adhesion cilium cell cortex triglyceride metabolic process calcium ion transport cellular calcium ion homeostasis endocytosis regulation of smooth muscle contraction skeletal muscle tissue development lactation protein localization negative regulation of cell proliferation response to mechanical stimulus response to bacterium basal plasma membrane positive regulation of signal transduction negative regulation of signal transduction cell surface positive regulation of calcium ion transport into cytosol posttranscriptional regulation of gene expression positive regulation of gene expression negative regulation of muscle cell apoptotic process positive regulation of peptidase activity membrane integral component of membrane basolateral plasma membrane apical plasma membrane peptidase activator activity receptor-mediated endocytosis of virus by host cell regulation of fatty acid metabolic process enzyme binding kinase binding protein kinase binding syntaxin binding lipid storage cell differentiation regulation of blood coagulation positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway protein binding, bridging negative regulation of epithelial cell differentiation mammary gland development positive regulation of microtubule polymerization T cell costimulation negative regulation of protein ubiquitination positive regulation of protein ubiquitination cytoplasmic vesicle receptor internalization negative regulation of protein binding positive regulation of protein binding maintenance of protein location in cell response to progesterone macromolecular complex negative regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation cholesterol efflux nitric oxide homeostasis receptor serine/threonine kinase binding positive regulation of toll-like receptor 3 signaling pathway wound healing vasoconstriction negative regulation of tyrosine phosphorylation of STAT protein cholesterol homeostasis identical protein binding positive regulation of catalytic activity negative regulation of MAP kinase activity negative regulation of MAPK cascade response to estrogen ion channel binding macromolecular complex binding negative regulation of nitric oxide biosynthetic process membrane raft negative regulation of neuron differentiation positive regulation of endocytosis positive regulation of vasoconstriction negative regulation of JAK-STAT cascade microtubule polymerization protein heterodimerization activity Rac GTPase binding perinuclear region of cytoplasm negative regulation of pinocytosis negative regulation of smooth muscle cell proliferation nitric-oxide synthase binding negative regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity ATPase binding regulation of cytosolic calcium ion concentration response to calcium ion membrane depolarization regulation of peptidase activity calcium ion homeostasis mammary gland involution binding, bridging positive regulation of cell adhesion molecule production negative regulation of necroptotic process negative regulation of protein tyrosine kinase activity inward rectifier potassium channel inhibitor activity negative regulation of ERK1 and ERK2 cascade caveola assembly cellular response to mechanical stimulus cellular response to exogenous dsRNA cellular response to peptide hormone stimulus cellular response to hyperoxia cellular response to transforming growth factor beta stimulus basement membrane organization caveolin-mediated endocytosis regulation of heart rate by cardiac conduction angiotensin-activated signaling pathway involved in heart process negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway cellular senescence apoptotic signaling pathway regulation of membrane repolarization during action potential regulation of ventricular cardiac muscle cell action potential regulation of ruffle assembly negative regulation of peptidyl-tyrosine autophosphorylation negative regulation of potassium ion transmembrane transport regulation of cell communication by electrical coupling involved in cardiac conduction positive regulation of ER-associated ubiquitin-dependent protein catabolic process positive regulation of gap junction assembly negative regulation of inward rectifier potassium channel activity receptor internalization involved in canonical Wnt signaling pathway regulation of entry of bacterium into host cell negative regulation of anoikis positive regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway negative regulation of cation channel activity sarcolemma uc009azo.1 uc009azo.2 uc009azo.3 uc009azo.4 
ENSMUST00000007803.12 Bcl2l1 ENSMUST00000007803.12 BCL2-like 1, transcript variant 3 (from RefSeq NM_009743.6) B2CL1_MOUSE Bcl2l Bclx ENSMUST00000007803.1 ENSMUST00000007803.10 ENSMUST00000007803.11 ENSMUST00000007803.2 ENSMUST00000007803.3 ENSMUST00000007803.4 ENSMUST00000007803.5 ENSMUST00000007803.6 ENSMUST00000007803.7 ENSMUST00000007803.8 ENSMUST00000007803.9 NM_009743 O35844 Q60657 Q60658 Q61338 Q64373 uc008ngm.1 uc008ngm.2 uc008ngm.3 uc008ngm.4 This gene encodes a member of the Bcl-2 family of apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]. Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles (By similarity). May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). Isoform Bcl-X(S) promotes apoptosis. Homodimer. Interacts with BAD. Interacts with PGAM5. Interacts with HEBP2. Interacts with p53/TP53 and BBC3; interaction with BBC3 disrupts the interaction with p53/TP53. Interacts with ATP5F1A and ATP5F1B; the interactions mediate the association of isoform Bcl-X(L) with the mitochondrial membrane ATP synthase F(1)F(0) ATP synthase (By similarity). Interacts with VDAC1 (By similarity). Interacts with BCL2L11 (via BH3) (PubMed:14499110, PubMed:27013495). Interacts with RNF183 (By similarity). Interacts with GIMAP3/IAN4 and GIMAP5/IAN5 (PubMed:16509771). Interacts with GIMAP5 and HSPA8/HSC70; the interaction between HSPA8 and BCL2L1 is impaired in the absence of GIMAP5 (PubMed:21502331). Interacts with isoform 4 of CLU; this interaction releases and activates BAX and promotes cell death (By similarity). [Isoform Bcl-X(L)]: Forms heterodimers with BAX, BAK or BCL2; heterodimerization with BAX does not seem to be required for anti- apoptotic activity (By similarity). Interacts with isoform 1 of SIVA1; the interaction inhibits the anti-apoptotic activity (By similarity). Interacts with IKZF3 (By similarity). Interacts with RTL10/BOP (By similarity). Interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF (By similarity). Interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (By similarity). Interacts with BECN1 (By similarity). Q64373; P59637: E; Xeno; NbExp=2; IntAct=EBI-526361, EBI-25487741; Q64373-1; Q61337: Bad; NbExp=2; IntAct=EBI-526380, EBI-400328; Mitochondrion membrane ; Single-pass membrane protein Nucleus membrane ; Single- pass membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to the centrosome when phosphorylated at Ser-49. [Isoform Bcl-X(L)]: Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Cytoplasm, cytosol Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner. [Isoform Bcl-X(delta-TM)]: Cytoplasm. Event=Alternative splicing; Named isoforms=4; Name=Bcl-X(L); Synonyms=Bcl-xL; IsoId=Q64373-1; Sequence=Displayed; Name=Bcl-X(S); Synonyms=Bcl-xS; IsoId=Q64373-2; Sequence=VSP_000517; Name=Bcl-X(beta); IsoId=Q64373-3; Sequence=VSP_000518; Name=Bcl-X(delta-TM); IsoId=Q64373-4; Sequence=VSP_000519; Widely expressed, with highest levels in the brain, thymus, bone marrow, and kidney. Bcl-X(L) and Bcl-X(delta-TM) expression is enhanced in B- and T-lymphocytes that have been activated. Bcl-X(beta) is expressed in both embryonal and postnatal tissues, whereas Bcl-X(L) is predominantly found in postnatal tissues. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl- 2 family members and for repression of cell death. The loop between motifs BH4 and BH3 is required for the interaction with NLRP1. Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity. Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA- damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis (By similarity). Ubiquitinated by RNF183 during prolonged ER stress, leading to degradation by the proteosome. Belongs to the Bcl-2 family. ovarian follicle development in utero embryonic development release of cytochrome c from mitochondria response to ischemia protein binding nucleus cytoplasm mitochondrion mitochondrial envelope mitochondrial outer membrane mitochondrial inner membrane mitochondrial matrix endoplasmic reticulum centrosome microtubule organizing center cytosol cytoskeleton apoptotic process mitotic cell cycle checkpoint germ cell development spermatogenesis transcription factor binding cell proliferation positive regulation of cell proliferation male gonad development intrinsic apoptotic signaling pathway in response to DNA damage response to radiation fertilization response to virus membrane integral component of membrane suppression by virus of host apoptotic process protein kinase binding cell junction clathrin binding synaptic vesicle membrane cytoplasmic vesicle nuclear membrane mitochondrial membrane regulation of cytokinesis response to cytokine synaptic vesicle recycling via endosome regulation of growth identical protein binding protein homodimerization activity regulation of apoptotic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of neuron apoptotic process macromolecular complex binding synapse response to cycloheximide regulation of mitochondrial membrane permeability protein heterodimerization activity GTPase binding BH domain binding neuron apoptotic process BH3 domain binding regulation of mitochondrial membrane potential cellular process regulating host cell cycle in response to virus mitochondrion morphogenesis cellular response to amino acid stimulus cellular response to alkaloid cellular response to gamma radiation apoptotic process in bone marrow negative regulation of release of cytochrome c from mitochondria Bcl-2 family protein complex extrinsic apoptotic signaling pathway in absence of ligand hepatocyte apoptotic process MDM2/MDM4 family protein binding presynapse negative regulation of execution phase of apoptosis positive regulation of synaptic vesicle endocytosis regulation of long term synaptic depression negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of protein localization to plasma membrane positive regulation of synaptic vesicle exocytosis positive regulation of synaptic vesicle clustering negative regulation of anoikis positive regulation of ATP biosynthetic process negative regulation of intrinsic apoptotic signaling pathway clathrin-coated pit uc008ngm.1 uc008ngm.2 uc008ngm.3 uc008ngm.4 
ENSMUST00000007814.10 Khsrp ENSMUST00000007814.10 KH-type splicing regulatory protein (from RefSeq NM_010613.3) E9QKH3 ENSMUST00000007814.1 ENSMUST00000007814.2 ENSMUST00000007814.3 ENSMUST00000007814.4 ENSMUST00000007814.5 ENSMUST00000007814.6 ENSMUST00000007814.7 ENSMUST00000007814.8 ENSMUST00000007814.9 FUBP2_MOUSE Fubp2 NM_010613 Q2VPQ6 Q3U0V1 Q6P2L2 uc008ddr.1 uc008ddr.2 uc008ddr.3 uc008ddr.4 Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU- rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs (By similarity). Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRPH1. Interacts with PARN. Interacts with PQBP1. Nucleus Cytoplasm Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. Belongs to the KHSRP family. nucleic acid binding DNA binding RNA binding mRNA binding mRNA 3'-UTR binding nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated mRNA processing mRNA catabolic process RNA splicing cytoplasmic stress granule miRNA metabolic process negative regulation of low-density lipoprotein particle clearance dendrite mRNA 3'-UTR AU-rich region binding neuronal cell body regulation of mRNA stability negative regulation of nitric oxide biosynthetic process mRNA transport positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization cellular response to cytokine stimulus regulation of miRNA metabolic process uc008ddr.1 uc008ddr.2 uc008ddr.3 uc008ddr.4 
ENSMUST00000007865.7 Ccdc124 ENSMUST00000007865.7 coiled-coil domain containing 124 (from RefSeq NM_026964.3) CC124_MOUSE ENSMUST00000007865.1 ENSMUST00000007865.2 ENSMUST00000007865.3 ENSMUST00000007865.4 ENSMUST00000007865.5 ENSMUST00000007865.6 NM_026964 Q8C2T0 Q9D8X2 uc009mby.1 uc009mby.2 uc009mby.3 Ribosome-binding protein involved in ribosome hibernation: associates with translationally inactive ribosomes and stabilizes the nonrotated conformation of the 80S ribosome, thereby promoting ribosome preservation and storage. Also required for proper progression of late cytokinetic stages. Associates with translationally inactive ribosomes in the nonrotated state. Interacts with RASGEF1B. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody Note=Colocalizes with gamma-tubulin at interphase, prophase, metaphase, and anaphase. Relocates from centrosome to midbody at telophase. Belongs to the CCDC124 family. cytoplasm microtubule organizing center cytosol cytoskeleton plasma membrane cell cycle biological_process midbody cell division uc009mby.1 uc009mby.2 uc009mby.3 
ENSMUST00000007949.4 Twist2 ENSMUST00000007949.4 twist basic helix-loop-helix transcription factor 2 (from RefSeq NM_007855.3) A5D6P6 A5D6P6_MOUSE ENSMUST00000007949.1 ENSMUST00000007949.2 ENSMUST00000007949.3 NM_007855 Twist2 uc007cbd.1 uc007cbd.2 uc007cbd.3 uc007cbd.4 nucleus nucleolus cytoplasm positive regulation of cell migration negative regulation of apoptotic process negative regulation of osteoblast differentiation protein dimerization activity uc007cbd.1 uc007cbd.2 uc007cbd.3 uc007cbd.4 
ENSMUST00000007959.14 Rhoa ENSMUST00000007959.14 ras homolog family member A, transcript variant 1 (from RefSeq NM_016802.5) Arha Arha2 ENSMUST00000007959.1 ENSMUST00000007959.10 ENSMUST00000007959.11 ENSMUST00000007959.12 ENSMUST00000007959.13 ENSMUST00000007959.2 ENSMUST00000007959.3 ENSMUST00000007959.4 ENSMUST00000007959.5 ENSMUST00000007959.6 ENSMUST00000007959.7 ENSMUST00000007959.8 ENSMUST00000007959.9 NM_016802 O88336 Q9QUI0 RHOA_MOUSE uc009rpe.1 uc009rpe.2 uc009rpe.3 uc009rpe.4 uc009rpe.5 This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]. Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:14697203). Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule- dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (By similarity). Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:11777936, PubMed:20974804). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis. Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center (By similarity). May be an activator of PLCE1 (PubMed:9635436). In neurons, involved in the inhibition of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (PubMed:14697203). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Activated by GEFs such as ARHGEF2, ARHGEF3, ARHGEF28 and BCR. Inhibited by GAPs such as ARHGAP30. Inhibited by GDP dissociation inhibitors such as ARHGDIA. Interacts with ARHGEF28 (PubMed:11058585). Interacts (via GTP- bound form) with RIPOR1 (via N-terminus); this interaction links RHOA to STK24 and STK26 kinases. Interacts with RIPOR2 (via active GTP- or inactive GDP-bound forms) isoform 1 and isoform 2; these interactions are direct, block the loading of GTP to RHOA and decrease upon chemokine CCL19 stimulation in primary T lymphocytes. Binds PRKCL1, ROCK1 and ROCK2 (By similarity). Interacts with ARHGEF2, ARHGEF3, NET1 and RTKN (PubMed:9535835, PubMed:8662891). Interacts with PLCE1 and AKAP13 (By similarity). Interacts with DIAPH1 (PubMed:9214622). Interacts (in the constitutively activated, GTP-bound form) with DGKQ. Interacts with RACK1; enhances RHOA activation. Interacts with PKP4; the interaction is detected at the midbody (By similarity). Interacts (GTP-bound form preferentially) with PKN2; the interaction stimulates autophosphorylation and phosphorylation of PKN2 (PubMed:20974804). Interacts with ARHGDIA; this interaction inactivates and stabilizes RHOA. Interacts with ARHGDIB (By similarity). Interacts (GTP-bound form) with KCNA2 (via cytoplasmic N-terminal domain) (PubMed:9635436). Interacts (GTP-bound form) with ECT2; the interaction results in allosteric activation of ECT2 (By similarity). Interacts with RAP1GDS1; the interaction is direct and in a 1:1 stoichiometry (By similarity). Q9QUI0; Q8C6B2: Rtkn; NbExp=3; IntAct=EBI-643583, EBI-1162441; Q9QUI0; Q9BST9: RTKN; Xeno; NbExp=2; IntAct=EBI-643583, EBI-446694; Cell membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasm, cytoskeleton Cleavage furrow Cytoplasm, cell cortex Midbody Cell projection, lamellipodium ll projection, dendrite Nucleus Cytoplasm Note=Localized to cell-cell contacts in calcium-treated keratinocytes (PubMed:11777936). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner (By similarity). Up-regulated during keratinocyte differentiation. Ubiquitinated by the BCR(KCTD13) and BCR(TNFAIP1) E3 ubiquitin ligase complexes, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and synaptic transmission in neurons. Ubiquitinated at Lys-135 in a FBXL19-mediated manner; leading to proteasomal degradation (By similarity). Phosphorylation by PRKG1 at Ser-188 inactivates RHOA signaling (By similarity). Phosphorylation by SLK at Ser-188 in response to AGTR2 activation (By similarity). Serotonylation of Gln-63 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity. Belongs to the small GTPase superfamily. Rho family. nucleotide binding cell morphogenesis response to hypoxia angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure alpha-beta T cell lineage commitment regulation of systemic arterial blood pressure by endothelin GTPase activity protein binding GTP binding nucleus cytoplasm mitochondrion endosome cytosol cytoskeleton plasma membrane cell cortex regulation of transcription from RNA polymerase II promoter cytoskeleton organization actin filament organization cell cycle cell adhesion cell-matrix adhesion integrin-mediated signaling pathway small GTPase mediated signal transduction Rho protein signal transduction skeletal muscle tissue development regulation of actin polymerization or depolymerization regulation of cell shape response to mechanical stimulus response to glucose negative regulation of cell-substrate adhesion regulation of neuron projection development negative regulation of neuron projection development membrane cell migration hydrolase activity myosin binding GDP binding protein kinase binding protein domain specific binding cerebral cortex cell migration forebrain radial glial cell differentiation lamellipodium actin cytoskeleton organization cell differentiation positive regulation of cell growth regulation of cell migration positive regulation of cell migration axon dendrite midbody androgen receptor signaling pathway positive regulation of actin filament polymerization establishment or maintenance of actin cytoskeleton polarity stress-activated protein kinase signaling cascade extrinsic component of cytoplasmic side of plasma membrane actin cytoskeleton reorganization vesicle cell division site cleavage furrow positive regulation of cytokinesis ruffle membrane regulation of actin cytoskeleton organization negative regulation of intracellular steroid hormone receptor signaling pathway regulation of osteoblast proliferation cell junction assembly Roundabout signaling pathway cleavage furrow formation apolipoprotein A-I-mediated signaling pathway odontogenesis response to drug cell projection positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling stress fiber assembly dendritic spine response to amino acid intracellular membrane-bounded organelle positive regulation of cysteine-type endopeptidase activity involved in apoptotic process apical junction complex apical junction assembly beta selection negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process endothelial cell migration ossification involved in bone maturation wound healing, spreading of cells establishment of epithelial cell apical/basal polarity response to ethanol negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of translation positive regulation of cell adhesion negative regulation of cell size positive regulation of vasoconstriction positive regulation of smooth muscle contraction GTP metabolic process positive regulation of alpha-beta T cell differentiation neuron projection morphogenesis regulation of dendrite development negative chemotaxis actin filament bundle assembly Rho GDP-dissociation inhibitor binding cell division response to glucocorticoid positive regulation of stress fiber assembly regulation of calcium ion transport positive regulation of lipase activity negative regulation of cell death trabecula morphogenesis regulation of microtubule cytoskeleton organization cellular response to lipopolysaccharide cellular response to cytokine stimulus positive regulation of podosome assembly positive regulation of protein serine/threonine kinase activity cell periphery negative regulation of cell migration involved in sprouting angiogenesis mitotic spindle assembly negative regulation of oxidative phosphorylation endothelial tube lumen extension postsynapse glutamatergic synapse positive regulation of NIK/NF-kappaB signaling skeletal muscle satellite cell migration negative regulation of reactive oxygen species biosynthetic process mitotic cleavage furrow formation positive regulation of vascular smooth muscle contraction positive regulation of leukocyte adhesion to vascular endothelial cell regulation of modification of synaptic structure regulation of modification of postsynaptic actin cytoskeleton cellular response to chemokine regulation of neural precursor cell proliferation positive regulation of T cell migration uc009rpe.1 uc009rpe.2 uc009rpe.3 uc009rpe.4 uc009rpe.5 
ENSMUST00000007961.15 Zmiz1 ENSMUST00000007961.15 zinc finger, MIZ-type containing 1, transcript variant 2 (from RefSeq NM_001310666.1) ENSMUST00000007961.1 ENSMUST00000007961.10 ENSMUST00000007961.11 ENSMUST00000007961.12 ENSMUST00000007961.13 ENSMUST00000007961.14 ENSMUST00000007961.2 ENSMUST00000007961.3 ENSMUST00000007961.4 ENSMUST00000007961.5 ENSMUST00000007961.6 ENSMUST00000007961.7 ENSMUST00000007961.8 ENSMUST00000007961.9 NM_001310666 Q6P1E1 Q6PDK9 Q6PF85 Q8BW47 Rai17 ZMIZ1_MOUSE Zimp10 uc007sro.1 uc007sro.2 uc007sro.3 uc007sro.4 uc007sro.5 Acts as a transcriptional coactivator. Increases ligand- dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (By similarity). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (By similarity). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (PubMed:26522984). Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex (By similarity). Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR. Interacts with NOTCH1 and RBPJ (By similarity). Interacts with SMARCA4. Interacts (via SP-RING-type domain) with SMAD3 and SMAD4 (via MH2 domain) (By similarity). Q6P1E1; Q3TKT4: Smarca4; NbExp=2; IntAct=EBI-647033, EBI-1210244; Nucleus, nucleoplasm Cytoplasm Note=Enriched at replication foci throughout S phase. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P1E1-1; Sequence=Displayed; Name=2; IsoId=Q6P1E1-2; Sequence=VSP_012187; Expressed in brain. The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein. The SP-RING-type domain mediates interaction with SMAD3 and SMAD4. Death between 9.5-10.5 dpc. Mice are approximately half the size of wild-type littermates and display vascular and cell viability defects. Some heterozygotes also do not survive but those that do have no apparent defects. [Isoform 2]: May be due to a competing acceptor splice site. Sequence=AAH57691.1; Type=Erroneous initiation; Evidence=; Sequence=BAC35753.1; Type=Frameshift; Evidence=; Sequence=BAC35753.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; RNA polymerase II transcription factor binding vasculogenesis in utero embryonic development heart morphogenesis transcription cofactor activity protein binding nucleus nucleoplasm cytoplasm regulation of transcription from RNA polymerase II promoter vitellogenesis cell aging zinc ion binding nuclear speck protein sumoylation ligand-dependent nuclear receptor transcription coactivator activity intracellular membrane-bounded organelle positive regulation of T cell differentiation positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter metal ion binding chromatin-mediated maintenance of transcription positive regulation of fibroblast proliferation developmental growth artery morphogenesis SUMO ligase activity uc007sro.1 uc007sro.2 uc007sro.3 uc007sro.4 uc007sro.5 
ENSMUST00000007980.7 Hnrnpa0 ENSMUST00000007980.7 heterogeneous nuclear ribonucleoprotein A0 (from RefSeq NM_029872.1) ENSMUST00000007980.1 ENSMUST00000007980.2 ENSMUST00000007980.3 ENSMUST00000007980.4 ENSMUST00000007980.5 ENSMUST00000007980.6 Hnrpa0 NM_029872 Q9CX86 ROA0_MOUSE uc007qtf.1 uc007qtf.2 uc007qtf.3 mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post- transcriptional regulation of cytokines mRNAs. Nucleus Note=Component of ribonucleosomes. Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA. Arg-293 is dimethylated, probably to asymmetric dimethylarginine. nucleic acid binding RNA binding mRNA binding nucleus nucleoplasm mRNA processing inflammatory response protein kinase binding response to lipopolysaccharide mRNA 3'-UTR AU-rich region binding 3'-UTR-mediated mRNA stabilization ribonucleoprotein complex uc007qtf.1 uc007qtf.2 uc007qtf.3 
ENSMUST00000007993.16 Rbm28 ENSMUST00000007993.16 RNA binding motif protein 28 (from RefSeq NM_133925.2) E9QKF8 ENSMUST00000007993.1 ENSMUST00000007993.10 ENSMUST00000007993.11 ENSMUST00000007993.12 ENSMUST00000007993.13 ENSMUST00000007993.14 ENSMUST00000007993.15 ENSMUST00000007993.2 ENSMUST00000007993.3 ENSMUST00000007993.4 ENSMUST00000007993.5 ENSMUST00000007993.6 ENSMUST00000007993.7 ENSMUST00000007993.8 ENSMUST00000007993.9 NM_133925 Q3U0K5 Q8BG25 Q8CGC6 Q8VEJ8 Q9CS22 Q9CSE6 RBM28_MOUSE uc009bcy.1 uc009bcy.2 uc009bcy.3 uc009bcy.4 Nucleolar component of the spliceosomal ribonucleoprotein complexes. Interacts with U1, U2, U4, U5, and U6 spliceosomal small nuclear RNAs (snRNAs). Nucleus, nucleolus nucleic acid binding RNA binding nucleus spliceosomal complex nucleolus mRNA processing biological_process RNA splicing ribonucleoprotein complex uc009bcy.1 uc009bcy.2 uc009bcy.3 uc009bcy.4 
ENSMUST00000008004.10 Ddx49 ENSMUST00000008004.10 DEAD box helicase 49, transcript variant 1 (from RefSeq NM_001024922.2) DDX49_MOUSE ENSMUST00000008004.1 ENSMUST00000008004.2 ENSMUST00000008004.3 ENSMUST00000008004.4 ENSMUST00000008004.5 ENSMUST00000008004.6 ENSMUST00000008004.7 ENSMUST00000008004.8 ENSMUST00000008004.9 NM_001024922 Q4FZF3 uc009lzu.1 uc009lzu.2 uc009lzu.3 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus rRNA processing hydrolase activity uc009lzu.1 uc009lzu.2 uc009lzu.3 
ENSMUST00000008016.3 Id3 ENSMUST00000008016.3 inhibitor of DNA binding 3 (from RefSeq NM_008321.2) ENSMUST00000008016.1 ENSMUST00000008016.2 Id3 NM_008321 Q545W1 Q545W1_MOUSE uc012dnf.1 uc012dnf.2 uc012dnf.3 Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Nucleus nucleus cytoplasm regulation of DNA replication response to wounding neuron differentiation positive regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated protein dimerization activity regulation of cell cycle uc012dnf.1 uc012dnf.2 uc012dnf.3 
ENSMUST00000008021.3 Tcap ENSMUST00000008021.3 titin-cap (from RefSeq NM_011540.2) ENSMUST00000008021.1 ENSMUST00000008021.2 NM_011540 Q545G3 Q545G3_MOUSE Tcap uc007lgf.1 uc007lgf.2 skeletal muscle contraction cardiac muscle hypertrophy adult heart development structural constituent of muscle cardiac muscle hypertrophy in response to stress Z disc skeletal muscle thin filament assembly skeletal muscle myosin thick filament assembly protein binding, bridging titin binding detection of muscle stretch BMP binding ion channel binding sarcomere organization cardiac muscle fiber development sarcomerogenesis FATZ binding cardiac myofibril assembly cardiac muscle tissue morphogenesis cardiac muscle contraction titin Z domain binding uc007lgf.1 uc007lgf.2 
ENSMUST00000008032.14 Crlf1 ENSMUST00000008032.14 cytokine receptor-like factor 1, transcript variant 8 (from RefSeq NR_184405.1) CRLF1_MOUSE Crlm3 ENSMUST00000008032.1 ENSMUST00000008032.10 ENSMUST00000008032.11 ENSMUST00000008032.12 ENSMUST00000008032.13 ENSMUST00000008032.2 ENSMUST00000008032.3 ENSMUST00000008032.4 ENSMUST00000008032.5 ENSMUST00000008032.6 ENSMUST00000008032.7 ENSMUST00000008032.8 ENSMUST00000008032.9 NR_184405 Q9JM58 uc009maj.1 uc009maj.2 uc009maj.3 uc009maj.4 In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (By similarity). Plays a role in the initiation and/or maintenance of suckling in neonatal mice (PubMed:10359701). May also play a regulatory role in the immune system (By similarity). Forms covalent di- and tetramers. Forms a heteromeric complex with cardiotrophin-like cytokine CLCF1/CLC; the CRLF1-CLCF1 complex is a ligand for the ciliary neurotrophic factor receptor/CNTFR. The CRLF1- CLCF1 heterodimer, as well as tripartite signaling complex formed by CRLF1, CLCF1 and CNTFR bind SORL1 (via N-terminal ectodomain); within this complex, the interaction is mediated predominantly by the CRLF1 moiety. Secreted Widely expressed in the embryo. Not detected in the brain of adult mice. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. Belongs to the type I cytokine receptor family. Type 3 subfamily. ureteric bud development cytokine receptor activity cytokine activity ciliary neurotrophic factor receptor binding extracellular region extracellular space signal transduction positive regulation of cell proliferation external side of plasma membrane cytokine-mediated signaling pathway cytokine binding positive regulation of tyrosine phosphorylation of STAT protein receptor complex negative regulation of neuron apoptotic process protein heterodimerization activity CRLF-CLCF1 complex negative regulation of motor neuron apoptotic process uc009maj.1 uc009maj.2 uc009maj.3 uc009maj.4 
ENSMUST00000008036.9 Rplp1 ENSMUST00000008036.9 ribosomal protein lateral stalk subunit P1 (from RefSeq NM_018853.3) ENSMUST00000008036.1 ENSMUST00000008036.2 ENSMUST00000008036.3 ENSMUST00000008036.4 ENSMUST00000008036.5 ENSMUST00000008036.6 ENSMUST00000008036.7 ENSMUST00000008036.8 NM_018853 Q58E35 Q58E35_MOUSE Rplp1 uc009pzt.1 uc009pzt.2 uc009pzt.3 Plays an important role in the elongation step of protein synthesis. Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein P1/P2 family. structural constituent of ribosome ribosome translational elongation cytosolic large ribosomal subunit uc009pzt.1 uc009pzt.2 uc009pzt.3 
ENSMUST00000008051.5 Cabs1 ENSMUST00000008051.5 calcium binding protein, spermatid specific 1 (from RefSeq NM_027631.3) CABS1_MOUSE ENSMUST00000008051.1 ENSMUST00000008051.2 ENSMUST00000008051.3 ENSMUST00000008051.4 NM_027631 Q8C633 Q9D4L4 uc008xzj.1 uc008xzj.2 uc008xzj.3 Calcium-binding protein (PubMed:19208547). Essential for maintaining the structural integrity of the sperm flagella (PubMed:33440775). Cytoplasm Mitochondrion inner membrane Cell projection, cilium, flagellum toplasmic vesicle, secretory vesicle, acrosome Note=Mostly cytoplasmic, but associated with the mitochondrial inner membrane during the last steps of spermatid differentiation (By similarity). Localizes to the principal piece of the sperm flagellum (PubMed:19208547, PubMed:33440775). Detected only in testis. Expressed from stages X to VIII of the seminiferous epithelial cycle. Expressed from step 13 to step 16 of spermatid development (at protein level). Down-regulated by Busulfan. Males exhibit significantly impaired sperm tail structure and subfertility (PubMed:33440775). Defects in sperm flagellar differentiation leads to an abnormal annulus and disorganization of the midpiece-principal piece junction (PubMed:33440775). calcium ion binding cytoplasm mitochondrion mitochondrial inner membrane cilium spermatogenesis motile cilium cell projection uc008xzj.1 uc008xzj.2 uc008xzj.3 
ENSMUST00000008052.13 Hmgcll1 ENSMUST00000008052.13 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1, transcript variant 1 (from RefSeq NM_173731.3) ENSMUST00000008052.1 ENSMUST00000008052.10 ENSMUST00000008052.11 ENSMUST00000008052.12 ENSMUST00000008052.2 ENSMUST00000008052.3 ENSMUST00000008052.4 ENSMUST00000008052.5 ENSMUST00000008052.6 ENSMUST00000008052.7 ENSMUST00000008052.8 ENSMUST00000008052.9 HMGC2_MOUSE NM_173731 Q8JZS7 uc009qsx.1 uc009qsx.2 uc009qsx.3 Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. Reaction=(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA; Xref=Rhea:RHEA:24404, ChEBI:CHEBI:13705, ChEBI:CHEBI:43074, ChEBI:CHEBI:57288; EC=4.1.3.4; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Metabolic intermediate metabolism; (S)-3-hydroxy-3- methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3- methylglutaryl-CoA: step 1/1. Cytoplasm, cytosol Endoplasmic reticulum membrane ; Peripheral membrane protein Belongs to the HMG-CoA lyase family. catalytic activity hydroxymethylglutaryl-CoA lyase activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol leucine catabolic process lipid metabolic process membrane lyase activity metal ion binding ketone body biosynthetic process perinuclear region of cytoplasm uc009qsx.1 uc009qsx.2 uc009qsx.3 
ENSMUST00000008088.9 Ttc9b ENSMUST00000008088.9 tetratricopeptide repeat domain 9B (from RefSeq NM_028417.1) ENSMUST00000008088.1 ENSMUST00000008088.2 ENSMUST00000008088.3 ENSMUST00000008088.4 ENSMUST00000008088.5 ENSMUST00000008088.6 ENSMUST00000008088.7 ENSMUST00000008088.8 NM_028417 Q8BYN8 Q9D6E4 TTC9B_MOUSE uc009fwu.1 uc009fwu.2 uc009fwu.3 Belongs to the TTC9 family. Sequence=BAC30153.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc009fwu.1 uc009fwu.2 uc009fwu.3 
ENSMUST00000008090.11 Phox2a ENSMUST00000008090.11 paired-like homeobox 2a (from RefSeq NM_008887.2) Arix ENSMUST00000008090.1 ENSMUST00000008090.10 ENSMUST00000008090.2 ENSMUST00000008090.3 ENSMUST00000008090.4 ENSMUST00000008090.5 ENSMUST00000008090.6 ENSMUST00000008090.7 ENSMUST00000008090.8 ENSMUST00000008090.9 NM_008887 PHX2A_MOUSE Phox2 Pmx2 Pmx2a Q62066 uc009ipe.1 uc009ipe.2 uc009ipe.3 May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype (By similarity). Nucleus Belongs to the paired homeobox family. nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding noradrenergic neuron differentiation DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development nervous system development somatic motor neuron differentiation oculomotor nerve formation trochlear nerve formation locus ceruleus development midbrain development sequence-specific DNA binding regulation of respiratory gaseous exchange positive regulation of transcription from RNA polymerase II promoter autonomic nervous system development enteric nervous system development sympathetic nervous system development parasympathetic nervous system development uc009ipe.1 uc009ipe.2 uc009ipe.3 
ENSMUST00000008094.10 Abhd8 ENSMUST00000008094.10 abhydrolase domain containing 8 (from RefSeq NM_022419.3) ABHD8_MOUSE Abhd8 ENSMUST00000008094.1 ENSMUST00000008094.2 ENSMUST00000008094.3 ENSMUST00000008094.4 ENSMUST00000008094.5 ENSMUST00000008094.6 ENSMUST00000008094.7 ENSMUST00000008094.8 ENSMUST00000008094.9 NM_022419 Q8R0P8 Q9DC79 Q9JMF5 uc009mdf.1 uc009mdf.2 uc009mdf.3 uc009mdf.4 Belongs to the AB hydrolase superfamily. It is uncertain whether Met-1 or Met-7 is the initiator. catalytic activity hydrolase activity uc009mdf.1 uc009mdf.2 uc009mdf.3 uc009mdf.4 
ENSMUST00000008350.16 Cers4 ENSMUST00000008350.16 ceramide synthase 4 (from RefSeq NM_026058.4) CERS4_MOUSE Cers4 ENSMUST00000008350.1 ENSMUST00000008350.10 ENSMUST00000008350.11 ENSMUST00000008350.12 ENSMUST00000008350.13 ENSMUST00000008350.14 ENSMUST00000008350.15 ENSMUST00000008350.2 ENSMUST00000008350.3 ENSMUST00000008350.4 ENSMUST00000008350.5 ENSMUST00000008350.6 ENSMUST00000008350.7 ENSMUST00000008350.8 ENSMUST00000008350.9 Lass4 NM_026058 Q8BZA6 Q8C151 Q9CX09 Q9D6J1 Trh1 uc009ktx.1 uc009ktx.2 uc009ktx.3 uc009ktx.4 Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. Reaction=octadecanoyl-CoA + sphinganine = CoA + H(+) + N- (octadecanoyl)-sphinganine; Xref=Rhea:RHEA:36547, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57817, ChEBI:CHEBI:67033; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36548; Evidence=; Reaction=eicosanoyl-CoA + sphinganine = CoA + H(+) + N- eicosanoylsphinganine; Xref=Rhea:RHEA:36555, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:57817, ChEBI:CHEBI:67027; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36556; Evidence=; Reaction=docosanoyl-CoA + sphinganine = CoA + H(+) + N- docosanoylsphinganine; Xref=Rhea:RHEA:36535, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:65059, ChEBI:CHEBI:67021; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36536; Evidence=; Reaction=sphinganine + tetracosanoyl-CoA = CoA + H(+) + N- tetracosanoylsphinganine; Xref=Rhea:RHEA:33591, ChEBI:CHEBI:15378, ChEBI:CHEBI:52961, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:65052; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33592; Evidence=; Reaction=hexacosanoyl-CoA + sphinganine = CoA + H(+) + N- hexacosanoylsphinganine; Xref=Rhea:RHEA:33351, ChEBI:CHEBI:15378, ChEBI:CHEBI:52962, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:64868; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33352; Evidence=; Reaction=a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+); Xref=Rhea:RHEA:23768, ChEBI:CHEBI:15378, ChEBI:CHEBI:52639, ChEBI:CHEBI:57287, ChEBI:CHEBI:57756, ChEBI:CHEBI:77636; EC=2.3.1.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23769; Evidence=; Reaction=octadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N- octadecanoylsphing-4-enine; Xref=Rhea:RHEA:36691, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57756, ChEBI:CHEBI:72961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36692; Evidence=; Reaction=hexadecasphinganine + octadecanoyl-CoA = CoA + H(+) + N- octadecanoylhexadecasphinganine; Xref=Rhea:RHEA:43044, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:71009, ChEBI:CHEBI:82811; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43045; Evidence=; Lipid metabolism; sphingolipid metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Ubiquitously expressed, with highest levels in skin. The last loop motif confers selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA) to behenoyl-CoA (docosanoyl-CoA; C22:0- CoA) as acyl donors. Phosphorylated at the C-terminus by CK2. Some prediction bioinformatics tools predict the presence of a homeobox domain (By similarity). However, the domain is degenerate and residues that are important for DNA-binding are absent (By similarity). Moreover, the protein localizes in the endoplasmic reticulum and not in the nucleus, strongly suggesting that it does not constitute a canonical homeobox domain (PubMed:12912983). DNA binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process sphingolipid metabolic process membrane integral component of membrane transferase activity sphingolipid biosynthetic process ceramide biosynthetic process sphingosine N-acyltransferase activity uc009ktx.1 uc009ktx.2 uc009ktx.3 uc009ktx.4 
ENSMUST00000008445.7 Phax ENSMUST00000008445.7 phosphorylated adaptor for RNA export, transcript variant 1 (from RefSeq NM_019996.4) ENSMUST00000008445.1 ENSMUST00000008445.2 ENSMUST00000008445.3 ENSMUST00000008445.4 ENSMUST00000008445.5 ENSMUST00000008445.6 NM_019996 PHAX_MOUSE Q8BSR8 Q9JJT9 Rnuxa uc008eyq.1 uc008eyq.2 uc008eyq.3 uc008eyq.4 A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA (By similarity). Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA. Part of a precomplex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20 and m7G-capped RNA. Interacts with NCBP1/CBP80. Found in a complex with snoRNA. Interacts with NCBP2/CBP20 (By similarity). Nucleus Nucleus, nucleoplasm Nucleus, Cajal body Cytoplasm Note=Shuttles between the nucleus and the cytoplasm. Shuttles between the nucleoplasm and Cajal bodies. Phosphorylated in the nucleus. Dephosphorylated in the cytoplasm. Belongs to the PHAX family. RNA binding nucleus nucleoplasm cytoplasm centrosome snRNA export from nucleus Cajal body protein transport toxic substance binding neuronal cell body uc008eyq.1 uc008eyq.2 uc008eyq.3 uc008eyq.4 
ENSMUST00000008451.12 1700109H08Rik ENSMUST00000008451.12 RIKEN cDNA 1700109H08 gene (from RefSeq NM_029843.3) 1700109H08Rik ENSMUST00000008451.1 ENSMUST00000008451.10 ENSMUST00000008451.11 ENSMUST00000008451.2 ENSMUST00000008451.3 ENSMUST00000008451.4 ENSMUST00000008451.5 ENSMUST00000008451.6 ENSMUST00000008451.7 ENSMUST00000008451.8 ENSMUST00000008451.9 NM_029843 Q9D9C0 Q9D9C0_MOUSE uc008wha.1 uc008wha.2 uc008wha.3 molecular_function calcium ion binding cellular_component biological_process uc008wha.1 uc008wha.2 uc008wha.3 
ENSMUST00000008462.11 Relt ENSMUST00000008462.11 RELT tumor necrosis factor receptor, transcript variant 1 (from RefSeq NM_177073.6) ENSMUST00000008462.1 ENSMUST00000008462.10 ENSMUST00000008462.2 ENSMUST00000008462.3 ENSMUST00000008462.4 ENSMUST00000008462.5 ENSMUST00000008462.6 ENSMUST00000008462.7 ENSMUST00000008462.8 ENSMUST00000008462.9 NM_177073 Q497Z8 Q8BTV0 Q8BX43 TR19L_MOUSE Tnfrsf19l uc009int.1 uc009int.2 uc009int.3 uc009int.4 May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel formation (PubMed:30506946). Interacts with RELL1, RELL2, OXSR1, PLSCR1 and STK39. Cell membrane ; Single-pass type I membrane protein Cytoplasm Cytoplasm, perinuclear region Expressed in the teeth. Expressed by secretory stage ameloblasts and by odontoblasts at postnatal day 5. It is not detected in maturation stage ameloblasts and only residual expression is observed in odontoblasts by postnatal day 12. Phosphorylated in vitro by OXSR1. Phosphorylated by STK39. Belongs to the RELT family. nucleus cytoplasm plasma membrane apoptotic process programmed cell death membrane integral component of membrane perinuclear region of cytoplasm uc009int.1 uc009int.2 uc009int.3 uc009int.4 
ENSMUST00000008477.13 Snrpb2 ENSMUST00000008477.13 U2 small nuclear ribonucleoprotein B (from RefSeq NM_021335.3) ENSMUST00000008477.1 ENSMUST00000008477.10 ENSMUST00000008477.11 ENSMUST00000008477.12 ENSMUST00000008477.2 ENSMUST00000008477.3 ENSMUST00000008477.4 ENSMUST00000008477.5 ENSMUST00000008477.6 ENSMUST00000008477.7 ENSMUST00000008477.8 ENSMUST00000008477.9 NM_021335 Q9CQI7 Q9CW35 Q9CZ66 RU2B_MOUSE uc008mqb.1 uc008mqb.2 uc008mqb.3 Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. Identified in the spliceosome B complex. Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro, and composed of SNRPB2, HPRP8BP and CRNKL1. Contributes to the binding of stem loop IV of U2 snRNA with SNRPP1. Nucleus Belongs to the RRM U1 A/B'' family. mRNA splicing, via spliceosome fibrillar center nucleic acid binding RNA binding protein binding nucleus spliceosomal complex U1 snRNP U2 snRNP mRNA processing RNA splicing nuclear speck small nuclear ribonucleoprotein complex U1 snRNA binding snRNP binding U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome uc008mqb.1 uc008mqb.2 uc008mqb.3 
ENSMUST00000008517.13 Prpf31 ENSMUST00000008517.13 pre-mRNA processing factor 31, transcript variant 1 (from RefSeq NM_027328.4) E9QPM6 ENSMUST00000008517.1 ENSMUST00000008517.10 ENSMUST00000008517.11 ENSMUST00000008517.12 ENSMUST00000008517.2 ENSMUST00000008517.3 ENSMUST00000008517.4 ENSMUST00000008517.5 ENSMUST00000008517.6 ENSMUST00000008517.7 ENSMUST00000008517.8 ENSMUST00000008517.9 NM_027328 PRP31_MOUSE Prp31 Q6P7X2 Q8BQ91 Q8C8U4 Q8C8V5 Q8CCF0 Q8CCG6 Q8CF52 Q8VBW3 uc009evi.1 uc009evi.2 uc009evi.3 uc009evi.4 uc009evi.5 Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. Identified in the spliceosome B complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Interacts with a complex formed by SNU13 and U4 snRNA, but not with SNU13 or U4 snRNA alone. The complex formed by SNU13 and PRPF31 binds also U4atac snRNA, a characteristic component of specific, less abundant spliceosomal complexes. Interacts with PRPF6/U5 snRNP-associated 102 kDa protein. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts (via its NLS) with CTNNBL1. Interacts with USH1G (By similarity). Nucleus Nucleus speckle Nucleus, Cajal body Note=Predominantly found in speckles and in Cajal bodies. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CCF0-1; Sequence=Displayed; Name=2; IsoId=Q8CCF0-2; Sequence=VSP_017591; Name=4; IsoId=Q8CCF0-4; Sequence=VSP_017589, VSP_017590; Interacts with the snRNP via the Nop domain. The coiled coil domain is formed by two non-contiguous helices. [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the PRP31 family. Sequence=BAC25109.1; Type=Frameshift; Evidence=; Sequence=BAC31903.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The C-terminus matches chromosome 19 region.; Evidence=; Sequence=BAC31931.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; Sequence=BAC34578.1; Type=Frameshift; Evidence=; spliceosomal tri-snRNP complex assembly mRNA splicing, via spliceosome RNA binding nucleus spliceosomal complex U4 snRNP U4atac snRNP mRNA processing RNA splicing Cajal body nuclear speck U4 snRNA binding U4atac snRNA binding ribonucleoprotein complex binding U4/U6 x U5 tri-snRNP complex snRNP binding U2-type precatalytic spliceosome ribonucleoprotein complex localization MLL1 complex uc009evi.1 uc009evi.2 uc009evi.3 uc009evi.4 uc009evi.5 
ENSMUST00000008528.8 Sertad1 ENSMUST00000008528.8 SERTA domain containing 1, transcript variant 1 (from RefSeq NM_018820.5) ENSMUST00000008528.1 ENSMUST00000008528.2 ENSMUST00000008528.3 ENSMUST00000008528.4 ENSMUST00000008528.5 ENSMUST00000008528.6 ENSMUST00000008528.7 NM_018820 Q925E6 Q9D888 Q9JL10 SRTD1_MOUSE Sei1 uc009fwh.1 uc009fwh.2 uc009fwh.3 Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A. Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Interacts with E2F1 and TFDP1; modulates transactivation activity of TFDP1/E2F complexes. Also interacts with CDK4. Detected at in testis, lung and, at lower levels, in muscle, liver, spleen, brain and heart. Detected as early as 7 dpc and persist until, at least, 17 dpc. Polyubiquitinated, which promotes proteasomal degradation. protein binding nucleus cytoplasm negative regulation of cell growth positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc009fwh.1 uc009fwh.2 uc009fwh.3 
ENSMUST00000008537.10 Carhsp1 ENSMUST00000008537.10 calcium regulated heat stable protein 1 (from RefSeq NM_025821.2) CHSP1_MOUSE ENSMUST00000008537.1 ENSMUST00000008537.2 ENSMUST00000008537.3 ENSMUST00000008537.4 ENSMUST00000008537.5 ENSMUST00000008537.6 ENSMUST00000008537.7 ENSMUST00000008537.8 ENSMUST00000008537.9 NM_025821 Q9CR86 uc007yct.1 uc007yct.2 uc007yct.3 Binds mRNA and regulates the stability of target mRNA. Homodimer. Interacts with STYX (By similarity). Cytoplasm Cytoplasm, P-body Cytoplasmic granule Note=Detected at cytoplasmic stress granules and P-bodies. Detected at exosome granules where mRNA is degraded. Can be phosphorylated by DYRK2 (in vitro). Dephosphorylated by calcineurin in a Ca(2+) dependent manner (By similarity). P-body nucleic acid binding RNA binding mRNA 3'-UTR binding protein binding cytoplasm cytosol P granule regulation of mRNA stability cytoplasmic exosome (RNase complex) uc007yct.1 uc007yct.2 uc007yct.3 
ENSMUST00000008542.12 Elk3 ENSMUST00000008542.12 ELK3, member of ETS oncogene family, transcript variant 1 (from RefSeq NM_013508.2) ELK3_MOUSE ENSMUST00000008542.1 ENSMUST00000008542.10 ENSMUST00000008542.11 ENSMUST00000008542.2 ENSMUST00000008542.3 ENSMUST00000008542.4 ENSMUST00000008542.5 ENSMUST00000008542.6 ENSMUST00000008542.7 ENSMUST00000008542.8 ENSMUST00000008542.9 Erp NM_013508 Net P41971 P97747 Q62346 Q8BWH1 uc011xlt.1 uc011xlt.2 uc011xlt.3 May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. Interacts with CTBP1. Nucleus. Heart, liver, lung, kidney and muscle. Belongs to the ETS family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm mitochondrion regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell differentiation purine-rich negative regulatory element binding wound healing sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc011xlt.1 uc011xlt.2 uc011xlt.3 
ENSMUST00000008573.9 Herpud2 ENSMUST00000008573.9 HERPUD family member 2 (from RefSeq NM_020586.2) ENSMUST00000008573.1 ENSMUST00000008573.2 ENSMUST00000008573.3 ENSMUST00000008573.4 ENSMUST00000008573.5 ENSMUST00000008573.6 ENSMUST00000008573.7 ENSMUST00000008573.8 HERP2_MOUSE MNCb-2040 NM_020586 Q8K2W2 Q9CSZ4 Q9D2D0 Q9JJC9 uc009oph.1 uc009oph.2 uc009oph.3 uc009oph.4 Could be involved in the unfolded protein response (UPR) pathway. Membrane ; Single-pass membrane protein molecular_function cellular_component response to unfolded protein spermatogenesis membrane integral component of membrane endoplasmic reticulum unfolded protein response uc009oph.1 uc009oph.2 uc009oph.3 uc009oph.4 
ENSMUST00000008579.14 Rdh13 ENSMUST00000008579.14 retinol dehydrogenase 13 (all-trans and 9-cis), transcript variant 1 (from RefSeq NM_175372.4) ENSMUST00000008579.1 ENSMUST00000008579.10 ENSMUST00000008579.11 ENSMUST00000008579.12 ENSMUST00000008579.13 ENSMUST00000008579.2 ENSMUST00000008579.3 ENSMUST00000008579.4 ENSMUST00000008579.5 ENSMUST00000008579.6 ENSMUST00000008579.7 ENSMUST00000008579.8 ENSMUST00000008579.9 NM_175372 Q8CC07 Q8CEE7 RDH13_MOUSE uc009exm.1 uc009exm.2 uc009exm.3 uc009exm.4 Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency. Has no activity towards steroid. Reaction=all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH; Xref=Rhea:RHEA:25033, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.300; Evidence=; Cofactor metabolism; retinol metabolism. Mitochondrion inner membrane ; Peripheral membrane protein Note=Localized on the outer side of the inner mitochondrial membrane. Belongs to the short-chain dehydrogenases/reductases (SDR) family. mitochondrion mitochondrial inner membrane response to high light intensity retina layer formation membrane oxidoreductase activity eye photoreceptor cell development retinol metabolic process retinal metabolic process NADP-retinol dehydrogenase activity oxidation-reduction process uc009exm.1 uc009exm.2 uc009exm.3 uc009exm.4 
ENSMUST00000008582.4 Adam21 ENSMUST00000008582.4 a disintegrin and metallopeptidase domain 21 (from RefSeq NM_020330.5) A2RSL1 ADA21_MOUSE Adam31 ENSMUST00000008582.1 ENSMUST00000008582.2 ENSMUST00000008582.3 NM_020330 Q9JI76 uc007ock.1 uc007ock.2 uc007ock.3 uc007ock.4 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. The encoded protein functions in the regulation of spermatogenesis in the testes and neurogenesis in the central nervous system. [provided by RefSeq, May 2016]. ##Evidence-Data-START## Transcript exon combination :: AK014827.2, BY714350.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Membrane; Single-pass type I membrane protein. Highly expressed in Leydig cells. Expressed also in cauda epididymidis, vas deferens, convoluted tubules, kidney and the parietal cells of stomach. Not detected on developing spermatocytes or mature sperm. A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding. The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated. metalloendopeptidase activity proteolysis peptidase activity metallopeptidase activity membrane integral component of membrane hydrolase activity axon neuron projection neuronal cell body metal ion binding uc007ock.1 uc007ock.2 uc007ock.3 uc007ock.4 
ENSMUST00000008594.9 Nutf2 ENSMUST00000008594.9 nuclear transport factor 2, transcript variant 1 (from RefSeq NM_026532.4) ENSMUST00000008594.1 ENSMUST00000008594.2 ENSMUST00000008594.3 ENSMUST00000008594.4 ENSMUST00000008594.5 ENSMUST00000008594.6 ENSMUST00000008594.7 ENSMUST00000008594.8 NM_026532 NTF2_MOUSE Ntf2 Nutf2 P13662 P61971 Q3TI35 uc009nej.1 uc009nej.2 uc009nej.3 uc009nej.4 Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. Homodimer. Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import. Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import. Interacts with CAPG; mediates its nuclear import. Cytoplasm, cytosol Nucleus outer membrane Nucleus, nuclear pore complex Nucleus inner membrane Nucleus, nucleoplasm Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. nucleus nuclear inner membrane nuclear outer membrane nuclear pore nucleoplasm cytoplasm cytosol protein import into nucleus protein export from nucleus nucleocytoplasmic transport Ran GTPase binding protein transport membrane structural constituent of nuclear pore nuclear membrane positive regulation of protein import into nucleus identical protein binding nuclear pore central transport channel mRNA transport nuclear import signal receptor activity protein localization to nuclear pore negative regulation of vascular endothelial growth factor production uc009nej.1 uc009nej.2 uc009nej.3 uc009nej.4 
ENSMUST00000008605.6 Fut1 ENSMUST00000008605.6 fucosyltransferase 1, transcript variant 1 (from RefSeq NM_008051.6) ENSMUST00000008605.1 ENSMUST00000008605.2 ENSMUST00000008605.3 ENSMUST00000008605.4 ENSMUST00000008605.5 FUT1_MOUSE Fut1 NM_008051 O09160 P97327 uc009gwg.1 uc009gwg.2 uc009gwg.3 This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is required for the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene impairs development of the olfactory nerve and maturation of the glomerular layer of the main olfactory bulb. Alternative splicing results in multiple transcript variants which encode distinct isoforms. [provided by RefSeq, Dec 2012]. Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:11368156, PubMed:14967068, PubMed:16884711). H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (PubMed:16884711). Preferentially fucosylates soluble lactose and to a lesser extent, fucosylates glycolipids gangliosides GA1 and GM1a (PubMed:11368156, PubMed:14967068). Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal- (1->4)-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:50668, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133507, ChEBI:CHEBI:133510; EC=2.4.1.344; Evidence=; Reaction=a ganglioside GA1 + GDP-beta-L-fucose = a ganglioside Fuc-GA1 + GDP + H(+); Xref=Rhea:RHEA:48320, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:88069, ChEBI:CHEBI:90262; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48321; Evidence=; Reaction=a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)- beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = alpha-L- fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D- glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1')-N-acylsphing-4-enine + GDP + H(+); Xref=Rhea:RHEA:32175, ChEBI:CHEBI:15378, ChEBI:CHEBI:17292, ChEBI:CHEBI:28743, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189; EC=2.4.1.69; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32176; Evidence=; Reaction=a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+); Xref=Rhea:RHEA:48304, ChEBI:CHEBI:15378, ChEBI:CHEBI:17006, ChEBI:CHEBI:28691, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48305; Evidence=; Reaction=a ganglioside GM1 + GDP-beta-L-fucose = a ganglioside Fuc-GM1 + GDP + H(+); Xref=Rhea:RHEA:48292, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:82639, ChEBI:CHEBI:90189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48293; Evidence=; Reaction=beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta- L-fucose = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl- D-galactosamine + GDP + H(+); Xref=Rhea:RHEA:62964, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:84728, ChEBI:CHEBI:546807; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62965; Evidence=; Kinetic parameters: KM=28.85 mM for phenyl-beta-D-Galactoside ; KM=29.09 mM for lactose ; KM=0.24 mM for ganglioside GA1 ; KM=22.5 uM for ganglioside GA1 ; KM=10.8 uM for nLc4Cer ; KM=6.2 uM for Lc4Cer ; KM=4.3 uM for GM1 ; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Note=Membrane-bound form in trans cisternae of Golgi. In the adult, highly expressed in pancreas, testis and epididymis and to a lesser extent in thymus, lung, stomach, small intestine, colon, spleen and uterus. Not expressed in brain, heart, skeletal muscle, kidney, liver and bone marrow (PubMed:9355741). Expressed in epididymis and testis (PubMed:11368156). Homozygous mutant knockout mice for Fut1 develop normally, exhibit no gross phenotypic abnormalities and the Fucalpha(1-->2)Galbeta epitope is absent from the epithelia of the epididymis mice. In mouse, there are three genes (Fut1, Fut2 and Sec1) which encode galactoside 2-L-fucosyltransferase. Belongs to the glycosyltransferase 11 family. Name=Functional Glycomics Gateway - GTase; Note=Fucosyltransferase 1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_611"; Golgi apparatus carbohydrate metabolic process protein glycosylation galactoside 2-alpha-L-fucosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups Golgi cisterna membrane fucosylation uc009gwg.1 uc009gwg.2 uc009gwg.3 
ENSMUST00000008626.10 Rnf151 ENSMUST00000008626.10 ring finger protein 151 (from RefSeq NM_026205.3) ENSMUST00000008626.1 ENSMUST00000008626.2 ENSMUST00000008626.3 ENSMUST00000008626.4 ENSMUST00000008626.5 ENSMUST00000008626.6 ENSMUST00000008626.7 ENSMUST00000008626.8 ENSMUST00000008626.9 NM_026205 Q9CQ29 RN151_MOUSE uc008axw.1 uc008axw.2 uc008axw.3 uc008axw.4 May be involved in acrosome formation of spermatids. Interacts with DTNBP1. Cytoplasm Nucleus Expressed in testis. Expressed in round spermatids of the stages VII-VIII semniniferous tubules. Expressed in elongating spermatids of stages VIII-IX seminiferous tubules (at protein level). nucleus cytoplasm spermatogenesis zinc ion binding cell differentiation metal ion binding uc008axw.1 uc008axw.2 uc008axw.3 uc008axw.4 
ENSMUST00000008684.11 Mgst1 ENSMUST00000008684.11 microsomal glutathione S-transferase 1, transcript variant 1 (from RefSeq NM_019946.5) ENSMUST00000008684.1 ENSMUST00000008684.10 ENSMUST00000008684.2 ENSMUST00000008684.3 ENSMUST00000008684.4 ENSMUST00000008684.5 ENSMUST00000008684.6 ENSMUST00000008684.7 ENSMUST00000008684.8 ENSMUST00000008684.9 MGST1_MOUSE NM_019946 Q91VS7 Q9CQ57 Q9R191 uc009enk.1 uc009enk.2 uc009enk.3 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16438; Evidence=; Homotrimer; The trimer binds only one molecule of glutathione. Endoplasmic reticulum membrane ; Multi-pass membrane protein Mitochondrion outer membrane Expressed in the testes (at protein level). Acetylation of Lys-42 and Lys-55 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the MAPEG family. glutathione transferase activity glutathione peroxidase activity nucleus mitochondrion mitochondrial outer membrane mitochondrial inner membrane peroxisomal membrane endoplasmic reticulum endoplasmic reticulum membrane glutathione metabolic process response to organonitrogen compound membrane integral component of membrane transferase activity response to lipopolysaccharide response to drug identical protein binding protein homodimerization activity intracellular membrane-bounded organelle glutathione binding apical part of cell oxidation-reduction process protein homotrimerization cellular response to lipid hydroperoxide cellular oxidant detoxification prostaglandin biosynthetic process prostaglandin-E synthase activity uc009enk.1 uc009enk.2 uc009enk.3 
ENSMUST00000008734.5 Htr3b ENSMUST00000008734.5 5-hydroxytryptamine (serotonin) receptor 3B (from RefSeq NM_020274.4) 5HT3B_MOUSE ENSMUST00000008734.1 ENSMUST00000008734.2 ENSMUST00000008734.3 ENSMUST00000008734.4 Htr3b NM_020274 Q9JHJ5 uc033jki.1 uc033jki.2 Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation- selective channel complexes, which when activated cause fast, depolarizing responses in neurons. Reaction=Na(+)(in) = Na(+)(out); Xref=Rhea:RHEA:34963, ChEBI:CHEBI:29101; Evidence=; Reaction=K(+)(in) = K(+)(out); Xref=Rhea:RHEA:29463, ChEBI:CHEBI:29103; Evidence=; Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671, ChEBI:CHEBI:29108; Evidence=; Forms homopentameric as well as heteropentameric serotonin- activated cation-selective channel complexes with HTR3A. The homomeric complex is not functional. Heteropentameric complexes display properties which resemble that of neuronal serotonin-activated channels in vivo. Postsynaptic cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. The HA-stretch region of HTR3B seems to confer increased conductance to HTR3A/HTR3B heteromers compared to that of HTR3A homomers. N-glycosylation is required for membrane localization. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub- subfamily. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane integral component of plasma membrane ion transport signal transduction serotonin receptor signaling pathway chemical synaptic transmission cell surface ligand-gated ion channel activity membrane integral component of membrane serotonin-gated cation channel activity axon positive regulation of ion transmembrane transporter activity ion transmembrane transport regulation of membrane potential neuron projection neuronal cell body synapse postsynaptic membrane neurological system process serotonin-activated cation-selective channel complex uc033jki.1 uc033jki.2 
ENSMUST00000008745.13 Rab25 ENSMUST00000008745.13 RAB25, member RAS oncogene family (from RefSeq NM_016899.4) ENSMUST00000008745.1 ENSMUST00000008745.10 ENSMUST00000008745.11 ENSMUST00000008745.12 ENSMUST00000008745.2 ENSMUST00000008745.3 ENSMUST00000008745.4 ENSMUST00000008745.5 ENSMUST00000008745.6 ENSMUST00000008745.7 ENSMUST00000008745.8 ENSMUST00000008745.9 NM_016899 Q9D1P3 Q9WTL2 RAB25_MOUSE Rab25 uc008pvn.1 uc008pvn.2 uc008pvn.3 Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (PubMed:22696678). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer. Interacts with VPS33B (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Cell projection, pseudopodium membrane Cytoplasmic vesicle Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips. Belongs to the small GTPase superfamily. Rab family. nucleotide binding epithelial cell morphogenesis GTPase activity protein binding GTP binding endosome plasma membrane intracellular protein transport exocytosis positive regulation of cell proliferation positive regulation of epithelial cell migration protein transport membrane pseudopodium pseudopodium membrane pseudopodium organization cytoplasmic vesicle myosin V binding Rab protein signal transduction cell projection recycling endosome regulation of vesicle-mediated transport uc008pvn.1 uc008pvn.2 uc008pvn.3 
ENSMUST00000008748.8 Ubqln4 ENSMUST00000008748.8 ubiquilin 4, transcript variant 1 (from RefSeq NM_033526.3) Cip75 ENSMUST00000008748.1 ENSMUST00000008748.2 ENSMUST00000008748.3 ENSMUST00000008748.4 ENSMUST00000008748.5 ENSMUST00000008748.6 ENSMUST00000008748.7 NM_033526 Q8BP88 Q99NB8 UBQL4_MOUSE Ubin Ubqln4 uc008pvr.1 uc008pvr.2 uc008pvr.3 Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (By similarity). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (By similarity). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (By similarity). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (By similarity). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (By similarity). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (By similarity). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (PubMed:18079109, PubMed:20940304). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (By similarity). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (By similarity). Homooligomer (By similarity). Binds signal sequences of proteins that are targeted to the endoplasmic reticulum (PubMed:11162551). Interacts (via UBA domain) with GJA1 (not ubiquitinated) and with ubiquitin; both compete for the same binding site (PubMed:18079109, PubMed:20127391, PubMed:20940304). Interacts (via UBA domain) with ubiquitin and with polyubiquitin chains (PubMed:20940304). Interacts (via ubiquitin-like domain) with PSMD2 and PSMD4, regulatory subunits of the 26S proteasome (PubMed:18079109). Interacts with ATXN1/SCA1; interaction with ATXN1 inhibits polyubiquitination of UBQLN4 and interferes with PSMD4 binding (By similarity). Interacts with HERPUD1 (By similarity). Interacts (via ubiquitin-like domain) with UBQLN1 (via UBA domain) (By similarity). Interacts with UBQLN2 (By similarity). Interacts (via STI1 1 and 2 domains) with MAP1LC3A/B/C (By similarity). Interacts with BAG6 (By similarity). Interacts with MRE11 (when ubiquitinated); interaction with ubiquitinated MRE11 leads to MRE11 removal from chromatin (By similarity). Interacts with DESI1/POST; leading to nuclear export (By similarity). Interacts with BCL2A1 and BCL2L10 (By similarity). Nucleus Cytoplasm Chromosome Endoplasmic reticulum toplasm, perinuclear region Cytoplasmic vesicle, autophagosome Note=Colocalizes with the proteasome, both in nucleus and cytoplasm. Exported from the nucleus following interaction with DESI1/POST. In response to DNA damage and phosphorylation at Ser-318 by ATM, localizes to the nucleus and is recruited to sites of DNA damage. Detected in testis, ovary, thyroid, kidney, thymus, heart, liver, lung and spleen (at protein level). Highly expressed in heart, skeletal muscle, kidney, liver and brain. Detected at lower levels in testis, lung and spleen. Phosphorylated by ATM at Ser-313 in response to DNA damage, leading to localization in the nucleus and recruitment to sites of DNA damage. Ubiquitinated; this does not lead to proteasomal degradation. May undergo both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. nucleus chromosome cytoplasm autophagosome endoplasmic reticulum endoplasmic reticulum membrane cytosol DNA repair ubiquitin-dependent protein catabolic process autophagy cellular response to DNA damage stimulus cytoplasmic vesicle polyubiquitin binding nuclear proteasome complex cytosolic proteasome complex regulation of proteasomal ubiquitin-dependent protein catabolic process identical protein binding perinuclear region of cytoplasm negative regulation of autophagosome maturation negative regulation of double-strand break repair via homologous recombination uc008pvr.1 uc008pvr.2 uc008pvr.3 
ENSMUST00000008812.9 Rps18 ENSMUST00000008812.9 ribosomal protein S18 (from RefSeq NM_011296.3) ENSMUST00000008812.1 ENSMUST00000008812.2 ENSMUST00000008812.3 ENSMUST00000008812.4 ENSMUST00000008812.5 ENSMUST00000008812.6 ENSMUST00000008812.7 ENSMUST00000008812.8 NM_011296 Q561N5 Q561N5_MOUSE Rps18 uc008cal.1 uc008cal.2 uc008cal.3 Component of the small ribosomal subunit. Cytoplasm Belongs to the universal ribosomal protein uS13 family. nucleic acid binding RNA binding structural constituent of ribosome ribosome translation uc008cal.1 uc008cal.2 uc008cal.3 
ENSMUST00000008826.14 Rpl10 ENSMUST00000008826.14 ribosomal protein L10 (from RefSeq NM_052835.4) ENSMUST00000008826.1 ENSMUST00000008826.10 ENSMUST00000008826.11 ENSMUST00000008826.12 ENSMUST00000008826.13 ENSMUST00000008826.2 ENSMUST00000008826.3 ENSMUST00000008826.4 ENSMUST00000008826.5 ENSMUST00000008826.6 ENSMUST00000008826.7 ENSMUST00000008826.8 ENSMUST00000008826.9 NM_052835 P45634 Q569M8 Q5M9K8 Q6ZWV3 Qm RL10_MOUSE Rpl10 uc009toc.1 uc009toc.2 uc009toc.3 uc009toc.4 Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes (PubMed:36517592). May play a role in the embryonic brain development (By similarity). Component of the large ribosomal subunit (PubMed:36517592). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:36517592). The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S) (PubMed:36517592). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:36517592). Cytoplasm Citrullinated by PADI4. Ufmylated by UFL1. Belongs to the universal ribosomal protein uL16 family. ribosomal large subunit assembly negative regulation of transcription from RNA polymerase II promoter structural constituent of ribosome nucleus cytoplasm endoplasmic reticulum cytosol ribosome translation regulation of translation multicellular organism development cytosolic large ribosomal subunit macromolecular complex negative regulation of apoptotic process translation regulator activity synapse liver regeneration embryonic brain development smooth endoplasmic reticulum uc009toc.1 uc009toc.2 uc009toc.3 uc009toc.4 
ENSMUST00000008830.10 Zfp955a ENSMUST00000008830.10 zinc finger protein 955A (from RefSeq NM_029952.3) D3Z5K4 ENSMUST00000008830.1 ENSMUST00000008830.2 ENSMUST00000008830.3 ENSMUST00000008830.4 ENSMUST00000008830.5 ENSMUST00000008830.6 ENSMUST00000008830.7 ENSMUST00000008830.8 ENSMUST00000008830.9 NM_029952 Q80XR7 Q80XR7_MOUSE Zfp422-rs1 Zfp955a Zfp955b uc008byf.1 uc008byf.2 uc008byf.3 uc008byf.4 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc008byf.1 uc008byf.2 uc008byf.3 uc008byf.4 
ENSMUST00000008878.10 Gprc5b ENSMUST00000008878.10 G protein-coupled receptor, family C, group 5, member B, transcript variant 2 (from RefSeq NM_022420.2) ENSMUST00000008878.1 ENSMUST00000008878.2 ENSMUST00000008878.3 ENSMUST00000008878.4 ENSMUST00000008878.5 ENSMUST00000008878.6 ENSMUST00000008878.7 ENSMUST00000008878.8 ENSMUST00000008878.9 GPC5B_MOUSE NM_022420 Q8CCV3 Q923Z0 Raig2 uc009jkx.1 uc009jkx.2 uc009jkx.3 uc009jkx.4 Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 3 family. positive regulation of protein phosphorylation G-protein coupled receptor activity nucleus nucleolus cytosol plasma membrane signal transduction G-protein coupled receptor signaling pathway locomotory behavior cell surface positive regulation of neuron projection development membrane integral component of membrane protein kinase binding protein kinase activator activity activation of protein kinase activity glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling intracellular membrane-bounded organelle receptor complex membrane raft positive regulation of neuron differentiation positive regulation of protein kinase activity positive regulation of inflammatory response positive regulation of macrophage cytokine production positive regulation of protein tyrosine kinase activity extracellular exosome positive regulation of canonical Wnt signaling pathway uc009jkx.1 uc009jkx.2 uc009jkx.3 uc009jkx.4 
ENSMUST00000008893.9 Coro1b ENSMUST00000008893.9 coronin, actin binding protein 1B, transcript variant 1 (from RefSeq NM_011778.3) COR1B_MOUSE ENSMUST00000008893.1 ENSMUST00000008893.2 ENSMUST00000008893.3 ENSMUST00000008893.4 ENSMUST00000008893.5 ENSMUST00000008893.6 ENSMUST00000008893.7 ENSMUST00000008893.8 NM_011778 Q3UEB1 Q9CVA2 Q9WUM3 uc008fyy.1 uc008fyy.2 uc008fyy.3 Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity). Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, stress fiber Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers. Ubiquitous. Phosphorylation on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location (By similarity). Belongs to the WD repeat coronin family. stress fiber actin binding protein binding cytoplasm cytosol cytoskeleton actin filament plasma membrane actin filament organization cytoskeletal protein binding cell migration lamellipodium actin cytoskeleton organization cell leading edge ruffle organization negative regulation of Arp2/3 complex-mediated actin nucleation endothelial cell chemotaxis cellular response to platelet-derived growth factor stimulus wound healing identical protein binding macromolecular complex binding perinuclear region of cytoplasm actin filament binding actin filament bundle assembly protein kinase C signaling negative regulation of smooth muscle cell chemotaxis Arp2/3 complex binding cell periphery actin filament branching protein localization to cell leading edge negative regulation of lamellipodium morphogenesis positive regulation of lamellipodium morphogenesis uc008fyy.1 uc008fyy.2 uc008fyy.3 
ENSMUST00000008907.14 Man1a2 ENSMUST00000008907.14 mannosidase, alpha, class 1A, member 2 (from RefSeq NM_010763.2) ENSMUST00000008907.1 ENSMUST00000008907.10 ENSMUST00000008907.11 ENSMUST00000008907.12 ENSMUST00000008907.13 ENSMUST00000008907.2 ENSMUST00000008907.3 ENSMUST00000008907.4 ENSMUST00000008907.5 ENSMUST00000008907.6 ENSMUST00000008907.7 ENSMUST00000008907.8 ENSMUST00000008907.9 MA1A2_MOUSE Man1b NM_010763 P39098 Q5SUY6 Q5SUY7 Q60599 Q9CUY9 uc008qqw.1 uc008qqw.2 uc008qqw.3 uc008qqw.4 uc008qqw.5 uc008qqw.6 Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). Reaction=4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- (1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = 4 beta-D-mannose + N(4)-(alpha-D-Man- (1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]- beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl- [protein] (N-glucan mannose isomer 5A1,2); Xref=Rhea:RHEA:56008, Rhea:RHEA-COMP:14356, Rhea:RHEA-COMP:14367, ChEBI:CHEBI:15377, ChEBI:CHEBI:28563, ChEBI:CHEBI:59087, ChEBI:CHEBI:139493; EC=3.2.1.113; Evidence=; Reaction=3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man- (1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D- Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man- (1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2); Xref=Rhea:RHEA:56028, Rhea:RHEA- COMP:14358, Rhea:RHEA-COMP:14367, ChEBI:CHEBI:15377, ChEBI:CHEBI:28563, ChEBI:CHEBI:59087, ChEBI:CHEBI:60628; EC=3.2.1.113; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Inhibited by both 1-deoxymannojirimycin and kifunensine. Protein modification; protein glycosylation. Golgi apparatus membrane; Single-pass type II membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P39098-1; Sequence=Displayed; Name=2; IsoId=P39098-2; Sequence=VSP_018615; Belongs to the glycosyl hydrolase 47 family. Golgi membrane catalytic activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity calcium ion binding endoplasmic reticulum Golgi apparatus protein glycosylation N-glycan processing respiratory gaseous exchange metabolic process glycoprotein metabolic process membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds metal ion binding lung alveolus development uc008qqw.1 uc008qqw.2 uc008qqw.3 uc008qqw.4 uc008qqw.5 uc008qqw.6 
ENSMUST00000008957.13 Tppp2 ENSMUST00000008957.13 Probable regulator of microtubule dynamics required for sperm motility (Probable). In contrast to other members of the family, has no microtubule bundling activity (By similarity). (from UniProt Q0P5Y3) BC049709 ENSMUST00000008957.1 ENSMUST00000008957.10 ENSMUST00000008957.11 ENSMUST00000008957.12 ENSMUST00000008957.2 ENSMUST00000008957.3 ENSMUST00000008957.4 ENSMUST00000008957.5 ENSMUST00000008957.6 ENSMUST00000008957.7 ENSMUST00000008957.8 ENSMUST00000008957.9 Gm77 Q0P5Y3 TPPP2_MOUSE Tppp2 uc007tnm.1 uc007tnm.2 Probable regulator of microtubule dynamics required for sperm motility (Probable). In contrast to other members of the family, has no microtubule bundling activity (By similarity). Cytoplasm, cytosol Cell projection, cilium, flagellum Note=Present in the middle piece of sperm tail. Only expressed in male reproductive organs, including testis (PubMed:30680919). Expressed in elongating spermatids at stages IV-VIII of the seminiferous epithelial cycle in testis and in mature sperm in the epididymis (PubMed:30680919). Male subfertility with a significantly decreased sperm count and motility (PubMed:30680919). Sperm shows increased irregular mitochondria lacking lamellar cristae, abnormal expression of electron transfer chain molecules, lower ATP levels, decreased mitochondrial membrane potential and increased apoptotic index (PubMed:30680919). Belongs to the TPPP family. microtubule bundle formation cytoplasm cytosol tubulin binding positive regulation of protein polymerization microtubule polymerization microtubule uc007tnm.1 uc007tnm.2 
ENSMUST00000008966.13 Acyp1 ENSMUST00000008966.13 acylphosphatase 1, transcript variant 3 (from RefSeq NM_025421.3) ACYP1_MOUSE Acype ENSMUST00000008966.1 ENSMUST00000008966.10 ENSMUST00000008966.11 ENSMUST00000008966.12 ENSMUST00000008966.2 ENSMUST00000008966.3 ENSMUST00000008966.4 ENSMUST00000008966.5 ENSMUST00000008966.6 ENSMUST00000008966.7 ENSMUST00000008966.8 ENSMUST00000008966.9 NM_025421 P56376 Q0VG40 Q545K8 Q6P8S7 uc007ogu.1 uc007ogu.2 uc007ogu.3 Reaction=an acyl phosphate + H2O = a carboxylate + H(+) + phosphate; Xref=Rhea:RHEA:14965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:43474, ChEBI:CHEBI:59918; EC=3.6.1.7; Evidence=; Belongs to the acylphosphatase family. acylphosphatase activity biological_process hydrolase activity uc007ogu.1 uc007ogu.2 uc007ogu.3 
ENSMUST00000008987.5 Cldn13 ENSMUST00000008987.5 claudin 13 (from RefSeq NM_020504.4) CLD13_MOUSE ENSMUST00000008987.1 ENSMUST00000008987.2 ENSMUST00000008987.3 ENSMUST00000008987.4 NM_020504 Q9Z0S4 uc008zwy.1 uc008zwy.2 uc008zwy.3 uc008zwy.4 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a developmentally expressed renal tight junction protein. This gene is expressed in the cecum, colon, liver and kidney of mice, but is not identified in rat tissues. Humans and chimpanzees lack this gene. [provided by RefSeq, Aug 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF516681.2, BY710282.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Belongs to the claudin family. structural molecule activity plasma membrane bicellular tight junction membrane integral component of membrane lateral plasma membrane cell junction uc008zwy.1 uc008zwy.2 uc008zwy.3 uc008zwy.4 
ENSMUST00000008991.8 Sptbn2 ENSMUST00000008991.8 spectrin beta, non-erythrocytic 2 (from RefSeq NM_021287.2) ENSMUST00000008991.1 ENSMUST00000008991.2 ENSMUST00000008991.3 ENSMUST00000008991.4 ENSMUST00000008991.5 ENSMUST00000008991.6 ENSMUST00000008991.7 NM_021287 Q68FG2 Q68FG2_MOUSE Spnb3 Sptbn2 uc008gan.1 uc008gan.2 uc008gan.3 uc008gan.4 Belongs to the spectrin family. Golgi membrane photoreceptor inner segment actin binding structural constituent of cytoskeleton phospholipid binding cytoplasm endosome cytosol cytoskeleton plasma membrane cytoskeleton organization synapse assembly synaptic vesicle spectrin synaptic vesicle exocytosis vesicle-mediated transport apical plasma membrane cerebellar Purkinje cell layer morphogenesis cell junction adult behavior multicellular organism growth neuronal cell body perinuclear region of cytoplasm actin filament capping presynapse structural constituent of synapse glutamatergic synapse uc008gan.1 uc008gan.2 uc008gan.3 uc008gan.4 
ENSMUST00000009003.9 Rala ENSMUST00000009003.9 v-ral simian leukemia viral oncogene A (ras related) (from RefSeq NM_019491.5) ENSMUST00000009003.1 ENSMUST00000009003.2 ENSMUST00000009003.3 ENSMUST00000009003.4 ENSMUST00000009003.5 ENSMUST00000009003.6 ENSMUST00000009003.7 ENSMUST00000009003.8 NM_019491 P05810 P63321 RALA_MOUSE Ral Ral-a uc007pof.1 uc007pof.2 uc007pof.3 Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (By similarity). The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (By similarity). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide- exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Interacts (via effector domain) with RALBP1; during mitosis, recruits RALBP1 to the mitochondrion where it promotes DNM1L phosphorylation and mitochondrial fission (By similarity). Interacts with EXOC2/Sec5 and EXOC8/Exo84; binding to EXOC2 and EXOC8 is mutually exclusive. Interacts with Clostridium exoenzyme C3. Interacts with RALGPS1. Interacts with LPAR1 and LPAR2. Interacts with GRK2 in response to LPAR1 activation. RALA and GRK2 binding to LPAR1 is mutually exclusive (By similarity). Interacts with CDC42 (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Cleavage furrow Midbody, Midbody ring Mitochondrion Note=Predominantly at the cell surface in the absence of LPA. In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicles. May colocalize with CNTRL/centriolin at the midbody ring. However, localization at the midbody at late cytokinesis was not confirmed. Relocalizes to the mitochondrion during mitosis where it regulates mitochondrial fission. Prenylation is essential for membrane localization. Phosphorylated. Phosphorylation at Ser-194 by AURKA/Aurora kinase A, during mitosis, induces RALA localization to the mitochondrion where it regulates mitochondrial fission. Belongs to the small GTPase superfamily. Ras family. nucleotide binding neural tube closure GTPase activity protein binding GTP binding plasma membrane exocytosis cell cycle signal transduction Ras protein signal transduction cell surface membrane myosin binding regulation of exocytosis GDP binding endocytic vesicle cytoplasmic vesicle membrane actin cytoskeleton reorganization ubiquitin protein ligase binding Edg-2 lysophosphatidic acid receptor binding cleavage furrow myelin sheath ATPase binding cell division positive regulation of filopodium assembly membrane raft localization Flemming body uc007pof.1 uc007pof.2 uc007pof.3 
ENSMUST00000009018.4 Clec3a ENSMUST00000009018.4 C-type lectin domain family 3, member a (from RefSeq NM_001007223.4) CLC3A_MOUSE Clecsf1 ENSMUST00000009018.1 ENSMUST00000009018.2 ENSMUST00000009018.3 Gm796 NM_001007223 Q9EPW4 uc009nob.1 uc009nob.2 uc009nob.3 uc009nob.4 Promotes cell adhesion to laminin and fibronectin. Secreted ossification extracellular region extracellular space carbohydrate binding uc009nob.1 uc009nob.2 uc009nob.3 uc009nob.4 
ENSMUST00000009036.11 Vdac3 ENSMUST00000009036.11 voltage-dependent anion channel 3, transcript variant 2 (from RefSeq NM_011696.2) ENSMUST00000009036.1 ENSMUST00000009036.10 ENSMUST00000009036.2 ENSMUST00000009036.3 ENSMUST00000009036.4 ENSMUST00000009036.5 ENSMUST00000009036.6 ENSMUST00000009036.7 ENSMUST00000009036.8 ENSMUST00000009036.9 NM_011696 Q60931 Q8BNG2 VDAC3_MOUSE uc009ldh.1 uc009ldh.2 uc009ldh.3 uc009ldh.4 Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). Involved in male fertility and sperm mitochondrial sheath formation (PubMed:35228556). Interacts with ARMC12 in a TBC1D21-dependent manner. Interacts with MISFA (PubMed:35228556). Mitochondrion outer membrane Membrane Note=May localize to non-mitochondrial membranes. Highest levels of expression detected in testis, less but still abundant expression in heart, kidney, brain, and skeletal muscle. Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. Male Vdac3-deficient mice are infertile as a result of reduced sperm mobility due to an abnormal mitochondrial sheat in spermatozoa. Belongs to the eukaryotic mitochondrial porin family. nucleotide binding behavioral fear response mitochondrion mitochondrial outer membrane mitochondrial inner membrane rough endoplasmic reticulum ion transport chemical synaptic transmission neuron-neuron synaptic transmission learning synaptic vesicle voltage-gated anion channel activity porin activity membrane integral component of membrane pore complex transmembrane transport anion transmembrane transport regulation of cilium assembly uc009ldh.1 uc009ldh.2 uc009ldh.3 uc009ldh.4 
ENSMUST00000009058.10 Abcb1b ENSMUST00000009058.10 ATP-binding cassette, sub-family B member 1B (from RefSeq NM_011075.2) Abcb1 Abcb1b ENSMUST00000009058.1 ENSMUST00000009058.2 ENSMUST00000009058.3 ENSMUST00000009058.4 ENSMUST00000009058.5 ENSMUST00000009058.6 ENSMUST00000009058.7 ENSMUST00000009058.8 ENSMUST00000009058.9 MDR1B_MOUSE Mdr1 Mdr1b NM_011075 P06795 Pgy1 Pgy1-1 uc008wkp.1 uc008wkp.2 uc008wkp.3 uc008wkp.4 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene encodes a membrane glycoprotein which confers a multidrug-resistance phenotype. The protein encoded by the human gene is an ATP-dependent drug efflux pump for xenobiotic compounds which is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC141363.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849379, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D- glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.; EC=7.6.2.2; Evidence=; Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:36439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:64612, ChEBI:CHEBI:456216; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38583, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57643, ChEBI:CHEBI:456216; Evidence=; Reaction=a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38943, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:22801, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Reaction=a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38903, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Translocase activity is inhibited by verapamil and is sensitive to energy depletion. C1orf115 regulates drug efflux through modulation of ABCB1 localization and activity. Interacts with PSMB5. Cell membrane ; Multi-pass membrane protein Apical cell membrane Cytoplasm Note=ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). Several phosphorylated serine residues are present in the linker domain. In mouse the MDR gene family includes three or more related but distinct cellular genes. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Golgi membrane nucleotide binding ATP binding mitochondrion plasma membrane lipid transport xenobiotic-transporting ATPase activity establishment of endothelial blood-brain barrier phospholipid transport membrane integral component of membrane apical plasma membrane ATPase activity response to drug ATPase activity, coupled to transmembrane movement of substances intercellular canaliculus transmembrane transport phosphatidylcholine-translocating ATPase activity phosphatidylethanolamine-translocating ATPase activity ceramide-translocating ATPase activity ceramide translocation uc008wkp.1 uc008wkp.2 uc008wkp.3 uc008wkp.4 
ENSMUST00000009102.9 Vps72 ENSMUST00000009102.9 vacuolar protein sorting 72 (from RefSeq NM_009336.2) ENSMUST00000009102.1 ENSMUST00000009102.2 ENSMUST00000009102.3 ENSMUST00000009102.4 ENSMUST00000009102.5 ENSMUST00000009102.6 ENSMUST00000009102.7 ENSMUST00000009102.8 NM_009336 Q3U2N4 Q62481 Q810A9 Q99K81 Tcfl1 VPS72_MOUSE Yl1 uc008qia.1 uc008qia.2 uc008qia.3 Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AZ1/H2AZ. Interacts (via N-terminal domain) with H2AZ1; the interaction is enhanced by VPS72 phosphorylation which is promoted by ZNHIT1 (PubMed:30842416). Nucleus In all tissues examined, most abundantly in brain and thymus. Phosphorylation is enhanced by ZNHIT1 and promotes the interaction of VPS72 with histone H2AZ1. Belongs to the VPS72/YL1 family. DNA binding nucleus chromatin organization chromatin remodeling regulation of transcription, DNA-templated nuclear speck macromolecular complex somatic stem cell population maintenance histone binding histone exchange uc008qia.1 uc008qia.2 uc008qia.3 
ENSMUST00000009120.8 Gabpa ENSMUST00000009120.8 GA repeat binding protein, alpha, transcript variant 1 (from RefSeq NM_008065.3) E4tf1a ENSMUST00000009120.1 ENSMUST00000009120.2 ENSMUST00000009120.3 ENSMUST00000009120.4 ENSMUST00000009120.5 ENSMUST00000009120.6 ENSMUST00000009120.7 GABPA_MOUSE NM_008065 Q00422 Q7TT22 uc007ztl.1 uc007ztl.2 uc007ztl.3 Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor Rhit/Zpf13. Heterotetramer of two alpha and two beta subunits. Nucleus. Ubiquitous. Belongs to the ETS family. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development blastocyst formation DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of gene expression cell differentiation activating transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of megakaryocyte differentiation positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity cellular response to dopamine uc007ztl.1 uc007ztl.2 uc007ztl.3 
ENSMUST00000009143.8 Bmp7 ENSMUST00000009143.8 bone morphogenetic protein 7 (from RefSeq NM_007557.3) BMP7_MOUSE Bmp-7 ENSMUST00000009143.1 ENSMUST00000009143.2 ENSMUST00000009143.3 ENSMUST00000009143.4 ENSMUST00000009143.5 ENSMUST00000009143.6 ENSMUST00000009143.7 NM_007557 Op1 P23359 Q91XF7 uc008odb.1 uc008odb.2 uc008odb.3 uc008odb.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Mutation of this gene results in skeletal, kidney, and other developmental defects. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010771.1, SRR1660817.185109.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:9013703, PubMed:22461901). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor. Can also signal through non- canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (By similarity). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509). Homodimer; disulfide-linked (By similarity). Interacts with SOSTDC1 (PubMed:14623234). Interacts with TWSG1 (PubMed:15843411). Interacts with FBN1 (via N-terminal domain) and FBN2 (By similarity). Interacts with type I receptor ACVR1 (By similarity). Interacts with type II receptor ACVR2A (By similarity). Interacts with NOG; this interaction inhibits canonical BMP signaling (By similarity). Interacts with SCUBE3 (By similarity). Interacts with ERFE; the interaction inhibits BMP-induced transcription of HAMP (PubMed:30097509). Secreted nullDeltion mutant mice die shortly after birth and display developmental defects in kidney, eye, skull, ribcage, and hind limbs. They also show defects in the development of the axial skeleton from the skull to the tail and the ossification of bones. Belongs to the TGF-beta family. ossification eye development metanephros development ureteric bud development mesoderm formation kidney development mesonephros development endocardial cushion formation pericardium morphogenesis cytokine activity transforming growth factor beta receptor binding protein binding extracellular region extracellular space multicellular organism development pattern specification process axon guidance salivary gland morphogenesis growth factor activity heparin binding negative regulation of cell proliferation embryonic pattern specification animal organ morphogenesis positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of peptidyl-threonine phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of cell death neural fold elevation formation cell differentiation embryonic limb morphogenesis positive regulation of bone mineralization BMP signaling pathway epithelial cell differentiation hindbrain development vesicle response to estradiol response to vitamin D positive regulation of heterotypic cell-cell adhesion protein localization to nucleus tube morphogenesis regulation of phosphorylation negative regulation of phosphorylation odontogenesis of dentin-containing tooth regulation of apoptotic process positive regulation of apoptotic process steroid hormone mediated signaling pathway negative regulation of MAP kinase activity regulation of MAPK cascade response to peptide hormone positive regulation of cell differentiation negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation negative regulation of Notch signaling pathway negative regulation of cell cycle negative regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell development camera-type eye morphogenesis embryonic camera-type eye morphogenesis anatomical structure formation involved in morphogenesis cardiac muscle tissue development branching morphogenesis of an epithelial tube mesenchymal cell differentiation neuron projection morphogenesis negative regulation of neurogenesis cartilage development pharyngeal system development embryonic skeletal joint morphogenesis regulation of pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction cardiac septum morphogenesis branching involved in salivary gland morphogenesis mesenchyme development negative regulation of cell death negative regulation of prostatic bud formation regulation of branching involved in prostate gland morphogenesis chorio-allantoic fusion heart trabecula morphogenesis monocyte aggregation BMP receptor binding cellular response to BMP stimulus negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis negative regulation of glomerular mesangial cell proliferation metanephric mesenchyme morphogenesis nephrogenic mesenchyme morphogenesis metanephric mesenchymal cell proliferation involved in metanephros development positive regulation of dendrite development positive regulation of hyaluranon cable assembly allantois development positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis uc008odb.1 uc008odb.2 uc008odb.3 uc008odb.4 
ENSMUST00000009157.4 Dynll1 ENSMUST00000009157.4 dynein light chain LC8-type 1 (from RefSeq NM_019682.5) DYL1_MOUSE Dlc1 Dncl1 Dnclc1 ENSMUST00000009157.1 ENSMUST00000009157.2 ENSMUST00000009157.3 NM_019682 P63168 Q15701 Q3UGE7 uc008zdp.1 uc008zdp.2 uc008zdp.3 uc008zdp.4 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity). Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1. Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non- catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The interaction with WWC1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at 'Ser-944') (By similarity). Interacts with BCL2L11 (PubMed:21478148). Interacts with BICD2 (PubMed:22956769). Interacts with BCAS1 (By similarity). Interacts with Bassoon/BSN (By similarity). Interacts with HDAC6 (By similarity). Interacts with TPPP (By similarity). Interacts with AMBRA1 (via TQT motifs); tethering AMBRA1 to the cytoskeleton (By similarity). Interacts with FAM83D/CHICA (via C-terminus) (By similarity). Interacts with HMMR, SPAG5/Astrin and KNSTRN/Kinastrin (By similarity). Interacts with TLK2 (By similarity). Interacts with NOS1 (By similarity). Interacts with WWC1, WWC2 and WWC3 (By similarity). P63168; Q64368: Dazl; NbExp=12; IntAct=EBI-349121, EBI-2024439; P63168; O88485: Dync1i1; NbExp=2; IntAct=EBI-349121, EBI-492834; P63168; P26367: PAX6; Xeno; NbExp=3; IntAct=EBI-349121, EBI-747278; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton Nucleus Mitochondrion Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria. Phosphorylation at Ser-88 appears to control the dimer-monomer transition. Belongs to the dynein light chain family. kinetochore motor activity enzyme inhibitor activity protein binding nucleus cytoplasm mitochondrion centrosome cytosol cytoskeleton cytoplasmic dynein complex microtubule microtubule associated complex cilium apoptotic process microtubule-based process spermatid development protein C-terminus binding COP9 signalosome membrane enzyme binding protein domain specific binding secretory granule nitric-oxide synthase regulator activity dynein complex intraciliary retrograde transport positive regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of phosphorylation protein homodimerization activity negative regulation of catalytic activity motile cilium assembly negative regulation of nitric oxide biosynthetic process dynein intermediate chain binding protein heterodimerization activity dynein light intermediate chain binding mitotic spindle scaffold protein binding positive regulation of non-motile cilium assembly axon cytoplasm positive regulation of ATP-dependent microtubule motor activity, plus-end-directed ATP-dependent microtubule motor activity, plus-end-directed uc008zdp.1 uc008zdp.2 uc008zdp.3 uc008zdp.4 
ENSMUST00000009174.15 Pdcl ENSMUST00000009174.15 phosducin-like (from RefSeq NM_026176.3) ENSMUST00000009174.1 ENSMUST00000009174.10 ENSMUST00000009174.11 ENSMUST00000009174.12 ENSMUST00000009174.13 ENSMUST00000009174.14 ENSMUST00000009174.2 ENSMUST00000009174.3 ENSMUST00000009174.4 ENSMUST00000009174.5 ENSMUST00000009174.6 ENSMUST00000009174.7 ENSMUST00000009174.8 ENSMUST00000009174.9 NM_026176 PHLP_MOUSE PhLP1 Q3TKI0 Q9DBX2 uc008jmp.1 uc008jmp.2 uc008jmp.3 Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers (PubMed:23637185). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (PubMed:29290584). Forms a complex with the beta and gamma subunits of the GTP- binding protein, transducin. Interacts with the CCT chaperonin complex (By similarity). Cell projection, cilium Conditional deletion in photoreceptor cells leads to 50-fold decrease in Gbeta-Ggamma dimer formation and more than 10- fold decrease in light sensitivity. A 20-fold reduction in Gbeta5 and RGS9-1 expression is also observed, causing a 15-fold delay in the shutoff of light responses. Belongs to the phosducin family. cytoplasm cilium protein folding visual perception cell projection organization cell projection macromolecular complex binding positive regulation of smoothened signaling pathway response to stimulus negative regulation of protein refolding heterotrimeric G-protein complex assembly uc008jmp.1 uc008jmp.2 uc008jmp.3 
ENSMUST00000009214.10 Rsph14 ENSMUST00000009214.10 Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. (from UniProt Q9D3W1) AK017008 ENSMUST00000009214.1 ENSMUST00000009214.2 ENSMUST00000009214.3 ENSMUST00000009214.4 ENSMUST00000009214.5 ENSMUST00000009214.6 ENSMUST00000009214.7 ENSMUST00000009214.8 ENSMUST00000009214.9 Q9D3W1 RSP14_MOUSE Rsph14 Rtdr1 uc287sdl.1 uc287sdl.2 Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. Component of the axonemal radial spoke complex 1 (RS1), at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB. Cytoplasm, cytoskeleton, flagellum axoneme Belongs to the flagellar radial spoke RSP14 family. molecular_function cellular_component biological_process uc287sdl.1 uc287sdl.2 
ENSMUST00000009219.3 Cabp7 ENSMUST00000009219.3 calcium binding protein 7 (from RefSeq NM_138948.4) CABP7_MOUSE Caln2 ENSMUST00000009219.1 ENSMUST00000009219.2 NM_138948 Q91ZM8 uc007hve.1 uc007hve.2 uc007hve.3 Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity). Golgi apparatus, trans-Golgi network membrane ; Single-pass type IV membrane protein Cytoplasm, perinuclear region Cell membrane ; Single-pass type IV membrane protein The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting. calcium ion binding cytoplasm Golgi apparatus plasma membrane biological_process membrane integral component of membrane trans-Golgi network membrane metal ion binding perinuclear region of cytoplasm uc007hve.1 uc007hve.2 uc007hve.3 
ENSMUST00000009220.5 Zmat5 ENSMUST00000009220.5 zinc finger, matrin type 5, transcript variant 1 (from RefSeq NM_026015.4) D11Bwg1548e ENSMUST00000009220.1 ENSMUST00000009220.2 ENSMUST00000009220.3 ENSMUST00000009220.4 NM_026015 Q9CQR5 ZMAT5_MOUSE uc007hvd.1 uc007hvd.2 uc007hvd.3 Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Not found in the major spliceosome (By similarity). Nucleus nucleus nucleoplasm spliceosomal complex U12-type spliceosomal complex mRNA processing biological_process zinc ion binding RNA splicing metal ion binding uc007hvd.1 uc007hvd.2 uc007hvd.3 
ENSMUST00000009234.16 Ap1b1 ENSMUST00000009234.16 adaptor protein complex AP-1, beta 1 subunit, transcript variant 2 (from RefSeq NM_007454.4) AP1B1_MOUSE Adtb1 ENSMUST00000009234.1 ENSMUST00000009234.10 ENSMUST00000009234.11 ENSMUST00000009234.12 ENSMUST00000009234.13 ENSMUST00000009234.14 ENSMUST00000009234.15 ENSMUST00000009234.2 ENSMUST00000009234.3 ENSMUST00000009234.4 ENSMUST00000009234.5 ENSMUST00000009234.6 ENSMUST00000009234.7 ENSMUST00000009234.8 ENSMUST00000009234.9 NM_007454 O35643 Q3TXG4 Q922E2 uc007hvo.1 uc007hvo.2 uc007hvo.3 uc007hvo.4 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Widely expressed. Belongs to the adaptor complexes large subunit family. protein binding Golgi apparatus trans-Golgi network cytosol intracellular protein transport determination of left/right symmetry heart development protein transport membrane vesicle-mediated transport protein kinase binding membrane coat clathrin adaptor complex clathrin binding clathrin-coated vesicle membrane cytoplasmic vesicle intracellular membrane-bounded organelle clathrin coat assembly uc007hvo.1 uc007hvo.2 uc007hvo.3 uc007hvo.4 
ENSMUST00000009236.6 Derl3 ENSMUST00000009236.6 Der1-like domain family, member 3, transcript variant 5 (from RefSeq NR_152573.1) DERL3_MOUSE Der3 Derl3 ENSMUST00000009236.1 ENSMUST00000009236.2 ENSMUST00000009236.3 ENSMUST00000009236.4 ENSMUST00000009236.5 Izp6 NR_152573 Q3T9L7 Q99KC6 Q9D8K3 Q9D954 uc007ftj.1 uc007ftj.2 uc007ftj.3 Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins. May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Forms homo- and heterooligomers with DERL2 and, to a lesser extent, with DERL1 (By similarity). Interacts with VCP and EDEM1 (By similarity). Interacts with SELENOK and SELENOS (PubMed:22016385). Interacts with the signal recognition particle/SRP and the SRP receptor; in the process of endoplasmic reticulum stress-induced pre- emptive quality control (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D8K3-1; Sequence=Displayed; Name=2; IsoId=Q9D8K3-2; Sequence=VSP_011090; Highly expressed in spleen, lung, liver, spleen and testis. Expressed at intermediate level in kidney. Weakly or not expressed in brain, heart and skeletal muscle. Expressed in neural cells during enbryogenesis. From 11.5 dpc until 14.5 dpc, it is mainly expressed in the forebrain. From 15.5 dpc until birth, expression in the forebrain becomes weaker but is still observed in the olfactory bulb and the skin around the eyes, nose, limbs and tail, showing that its pattern of expression changes from the central nervous system to the peripheral tissues during development. Belongs to the derlin family. Sequence=AAH04729.1; Type=Erroneous initiation; Evidence=; Hrd1p ubiquitin ligase ERAD-L complex endoplasmic reticulum signal recognition particle receptor complex endoplasmic reticulum membrane membrane integral component of membrane protein N-linked glycosylation via asparagine integral component of endoplasmic reticulum membrane ER-associated ubiquitin-dependent protein catabolic process endoplasmic reticulum unfolded protein response signal recognition particle misfolded protein binding negative regulation of retrograde protein transport, ER to cytosol ubiquitin-specific protease binding uc007ftj.1 uc007ftj.2 uc007ftj.3 
ENSMUST00000009241.7 Tbx1 ENSMUST00000009241.7 T-box 1, transcript variant 4 (from RefSeq NM_001373938.1) ENSMUST00000009241.1 ENSMUST00000009241.2 ENSMUST00000009241.3 ENSMUST00000009241.4 ENSMUST00000009241.5 ENSMUST00000009241.6 F6ZP09 F6ZP09_MOUSE NM_001373938 Tbx1 uc007yoh.1 uc007yoh.2 uc007yoh.3 Nucleus Lacks conserved residue(s) required for the propagation of feature annotation. DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated uc007yoh.1 uc007yoh.2 uc007yoh.3 
ENSMUST00000009256.4 Bcl2l13 ENSMUST00000009256.4 BCL2 like 13 (from RefSeq NM_153516.2) B2L13_MOUSE ENSMUST00000009256.1 ENSMUST00000009256.2 ENSMUST00000009256.3 Mil1 NM_153516 P59017 Q543S1 uc009dnt.1 uc009dnt.2 uc009dnt.3 May promote the activation of caspase-3 and apoptosis. Monomer. Mitochondrion membrane ; Single-pass membrane protein Belongs to the Bcl-2 family. molecular_function mitochondrion apoptotic process membrane integral component of membrane mitochondrial membrane regulation of apoptotic process uc009dnt.1 uc009dnt.2 uc009dnt.3 
ENSMUST00000009259.5 Spatc1l ENSMUST00000009259.5 spermatogenesis and centriole associated 1 like, transcript variant 1 (from RefSeq NM_029661.1) B2RW50 ENSMUST00000009259.1 ENSMUST00000009259.2 ENSMUST00000009259.3 ENSMUST00000009259.4 NM_029661 Q9D9W0 SPC1L_MOUSE uc007fur.1 uc007fur.2 uc007fur.3 Belongs to the speriolin family. molecular_function centrosome biological_process uc007fur.1 uc007fur.2 uc007fur.3 
ENSMUST00000009321.11 Dgcr8 ENSMUST00000009321.11 DGCR8, microprocessor complex subunit (from RefSeq NM_033324.2) DGCR8_MOUSE ENSMUST00000009321.1 ENSMUST00000009321.10 ENSMUST00000009321.2 ENSMUST00000009321.3 ENSMUST00000009321.4 ENSMUST00000009321.5 ENSMUST00000009321.6 ENSMUST00000009321.7 ENSMUST00000009321.8 ENSMUST00000009321.9 NM_033324 Q9EQM6 uc007ynf.1 uc007ynf.2 uc007ynf.3 uc007ynf.4 Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis (PubMed:17259983). Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA- ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (By similarity). Involved in the silencing of embryonic stem cell self-renewal (PubMed:17259983). Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Note=Binds 1 heme group per homodimer. ; Monomer; in absence of heme (By similarity). Homodimer; the association with heme promotes its dimerization (By similarity). Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8 (PubMed:26255770). The microprocessor complex is a heterotrimer; each of the two DROSHA RNase III domains binds one DGCR8 (via C-terminal region) (By similarity). Interacts with ILF3, NCL and DROSHA (By similarity). Interacts with CPSF3 and ISY1; this interaction is in an RNA dependent manner (PubMed:26255770). Interacts with PUS10; interaction promotes pri-miRNAs processing (By similarity). Nucleus Nucleus, nucleolus Note=Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies. Ubiquitously expressed. Expressed in embryonic stem cells. During embryo development it is expressed in neuroepithelium of primary brain, limb bud, vessels, thymus, and around the palate. RNA binding double-stranded RNA binding nucleus nucleoplasm nucleolus cytoplasm postsynaptic density heme binding primary miRNA processing identical protein binding protein homodimerization activity metal ion binding microprocessor complex primary miRNA binding regulation of stem cell proliferation RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic ribonuclease III activity uc007ynf.1 uc007ynf.2 uc007ynf.3 uc007ynf.4 
ENSMUST00000009329.3 Ccl8 ENSMUST00000009329.3 C-C motif chemokine ligand 8 (from RefSeq NM_021443.3) CCL8_MOUSE ENSMUST00000009329.1 ENSMUST00000009329.2 Mcp2 NM_021443 Q9Z121 Scya8 uc007kmt.1 uc007kmt.2 uc007kmt.3 Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity). Monomer or homodimer; in equilibrium. Secreted Belongs to the intercrine beta (chemokine CC) family. monocyte chemotaxis cytokine activity extracellular region extracellular space chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway chemokine activity heparin binding neutrophil chemotaxis positive regulation of GTPase activity positive regulation of myoblast differentiation CCR chemokine receptor binding eosinophil chemotaxis lymphocyte chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of myoblast fusion uc007kmt.1 uc007kmt.2 uc007kmt.3 
ENSMUST00000009340.10 Ifi211 ENSMUST00000009340.10 interferon activated gene 211, transcript variant 2 (from RefSeq NM_001301745.1) B7ZNS3 ENSMUST00000009340.1 ENSMUST00000009340.2 ENSMUST00000009340.3 ENSMUST00000009340.4 ENSMUST00000009340.5 ENSMUST00000009340.6 ENSMUST00000009340.7 ENSMUST00000009340.8 ENSMUST00000009340.9 IFI5B_MOUSE Ifi205b Mnda NM_001301745 P0DOV1 P15092 Q08619 Q3TM07 Q3U776 Q3U7F4 Q3U7K5 Q3UCH9 Q8C4X3 Q921V9 uc007dsa.1 uc007dsa.2 uc007dsa.3 uc007dsa.4 The protein encoded by this gene is a member of the interferon-regulated 200 family of proteins, which contain an N-terminal pyrin domain that is proposed to function in cell death and a partially conserved 220 amino acid domain. Expression of this protein in embryonic stem cells is critical for the DNA damage response and regulation of cell survival. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. May act as a transcriptional regulator in the myeloid lineage. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Interacts with TP53, RB1, CDK1, CDK2 and HOXB2. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P0DOV1-1; Sequence=Displayed; Name=2; IsoId=P0DOV1-2; Sequence=VSP_058589; Mononuclear phagocytes. By lipopolysaccharides (LPS). Belongs to the HIN-200 family. The family of genes to which Mnda belongs has undergone a rapid expansion in the mouse. As a consequence, mouse Mnda and human MNDA genes, although belonging to the same family, are not one to one orthologs. Sequence=BAE31364.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding activation of innate immune response double-stranded DNA binding nucleus nucleolus cytosol transcription factor binding response to bacterium nuclear speck positive regulation of interleukin-1 beta production nuclear periphery cellular response to interferon-beta identical protein binding uc007dsa.1 uc007dsa.2 uc007dsa.3 uc007dsa.4 
ENSMUST00000009356.11 Serpinb2 ENSMUST00000009356.11 serine (or cysteine) peptidase inhibitor, clade B, member 2, transcript variant 2 (from RefSeq NM_001174170.1) ENSMUST00000009356.1 ENSMUST00000009356.10 ENSMUST00000009356.2 ENSMUST00000009356.3 ENSMUST00000009356.4 ENSMUST00000009356.5 ENSMUST00000009356.6 ENSMUST00000009356.7 ENSMUST00000009356.8 ENSMUST00000009356.9 NM_001174170 Q542A3 Q542A3_MOUSE Serpinb2 uc007chn.1 uc007chn.2 uc007chn.3 uc007chn.4 Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular space negative regulation of endopeptidase activity wound healing negative regulation of apoptotic process uc007chn.1 uc007chn.2 uc007chn.3 uc007chn.4 
ENSMUST00000009358.9 Mymk ENSMUST00000009358.9 myomaker, myoblast fusion factor, transcript variant 1 (from RefSeq NM_025376.3) ENSMUST00000009358.1 ENSMUST00000009358.2 ENSMUST00000009358.3 ENSMUST00000009358.4 ENSMUST00000009358.5 ENSMUST00000009358.6 ENSMUST00000009358.7 ENSMUST00000009358.8 MYMK_MOUSE Mymk NM_025376 Q9D1N4 Tmem8c uc008iwz.1 uc008iwz.2 uc008iwz.3 uc008iwz.4 Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:23868259, PubMed:28386024, PubMed:28681861, PubMed:30197239). Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX (PubMed:30197239). Acts independently of MYMX (PubMed:30197239). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (PubMed:25085416). Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satellite cells with myofibers (PubMed:28186492). Interacts with MYMX (PubMed:28386024). Cell membrane ulti-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Note=Localizes on the plasma membrane of myoblasts, where it mediates myoblasts fusion (PubMed:23868259, PubMed:28860190). Also localizes in the Golgi apparatus and post-Golgi following palmitoylation; the role of Golgi localization is unclear (PubMed:28860190). Specifically expressed in skeletal muscle during embryogenesis and adult muscle regeneration. During embryogenesis, highly expressed in the myotome compartment of the somites, and later in limb buds and axial skeletal muscles. Specifically expressed in skeletal muscle, and not in other muscle tissues or non-muscle tissues. Expression is down- regulated postnatally. Expression is induced in muscles in response to muscle injury (PubMed:25085416). Expression is induced in muscle progenitors response to muscle overload (PubMed:28186492). Down-regulated by in microRNA miR-491, which binds specifically to its 3' untranslated region of Mymk leading to its down-regulation (PubMed:28579197). Palmitoylated at the C-terminus; palmitoylation promotes localization to the Golgi apparatus. Perinatal death due to an absence of multi- nucleated muscle fibers (PubMed:23868259). Mice are observed at normal Mendelian ratios at 15 dpc and 17.5 dpc, full-term embryos are alive but are paralyzed and kyphotic with flaccid limbs due to skeletal muscle deficiency (PubMed:23868259). They show a complete absence of differentiated muscle tissue in the trunk, limbs or head (PubMed:23868259). Myoblasts can activate muscle-specific gene expression and differentiate, but lack the ability to fuse (PubMed:23868259). Defects are caused by impaired lipid mixing of cell membranes (PubMed:30197239). Conditional deletion in adult satellite cells, a population of muscle stem cells, completely abolishes muscle regeneration after injury, resulting in severe muscle destruction (PubMed:25085416). Conditional deletion in adult satellite cells impairs skeletal muscle hypertrophy in response to exercise (PubMed:28186492). Belongs to the TMEM8 family. Golgi membrane protein binding Golgi apparatus plasma membrane integral component of plasma membrane muscle organ development myoblast fusion myoblast fusion involved in skeletal muscle regeneration membrane integral component of membrane integral component of Golgi membrane skeletal muscle tissue regeneration plasma membrane fusion positive regulation of skeletal muscle hypertrophy uc008iwz.1 uc008iwz.2 uc008iwz.3 uc008iwz.4 
ENSMUST00000009390.10 Trpm5 ENSMUST00000009390.10 transient receptor potential cation channel, subfamily M, member 5 (from RefSeq NM_020277.2) A3KN89 ENSMUST00000009390.1 ENSMUST00000009390.2 ENSMUST00000009390.3 ENSMUST00000009390.4 ENSMUST00000009390.5 ENSMUST00000009390.6 ENSMUST00000009390.7 ENSMUST00000009390.8 ENSMUST00000009390.9 Ltrpc5 Mtr1 NM_020277 Q3TU14 Q7TPL4 Q99NF9 Q9EPM3 Q9EPM4 Q9JJH7 TRPM5_MOUSE Trpm5 uc009kpa.1 uc009kpa.2 uc009kpa.3 Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals. Phosphatidylinositol 4,5-bisphosphate (PIP2) is able to partially restore sensitivity to Ca(2+) after desensitization. Inhibited by flufenamic acid with an IC(50) of 24.5 uM and spermine with an IC(50) of 37 uM. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1 IsoId=Q9JJH7-1; Sequence=Displayed; Name=2 ; IsoId=Q9JJH7-2; Sequence=VSP_052746, VSP_052747; Name=3 ; IsoId=Q9JJH7-3; Sequence=VSP_052744, VSP_052745; Strongly expressed in liver, heart, testis, brain and kidney. Detected in fetal liver, kidney, spleen, brain, heart and lung, and in adult skin, eyes, spleen, stomach, small intestine, colon, lung, bladder, pancreas and thymus. Biallelically expressed at all stages and tissues examined. Also expressed in subsets of taste receptor cells of the tongue, in olfactory sensory neurons of the main olfactory epithelium and in the vomeronasal organ. Mice show diminished behavioral and nerve responses to bitter, sweet and umami tastes. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM5 sub-subfamily. Sequence=CAB94717.2; Type=Frameshift; Evidence=; Sequence=CAC19456.1; Type=Frameshift; Evidence=; ion channel activity calcium activated cation channel activity voltage-gated ion channel activity potassium channel activity sodium channel activity plasma membrane ion transport cation transport membrane integral component of membrane dendrite ion transmembrane transport regulation of ion transmembrane transport sodium ion transmembrane transport neuronal cell body sensory perception of taste transmembrane transport potassium ion transmembrane transport uc009kpa.1 uc009kpa.2 uc009kpa.3 
ENSMUST00000009411.9 Zfp212 ENSMUST00000009411.9 Zinc finger protein 212, transcript variant 1 (from RefSeq NM_145576.2) ENSMUST00000009411.1 ENSMUST00000009411.2 ENSMUST00000009411.3 ENSMUST00000009411.4 ENSMUST00000009411.5 ENSMUST00000009411.6 ENSMUST00000009411.7 ENSMUST00000009411.8 G3X8R7 G3X8R7_MOUSE NM_145576 Zfp212 uc009btm.1 uc009btm.2 uc009btm.3 uc009btm.4 uc009btm.5 nucleic acid binding nucleus regulation of transcription, DNA-templated identical protein binding metal ion binding uc009btm.1 uc009btm.2 uc009btm.3 uc009btm.4 uc009btm.5 
ENSMUST00000009435.12 Pttg1ip ENSMUST00000009435.12 pituitary tumor-transforming 1 interacting protein (from RefSeq NM_145925.3) ENSMUST00000009435.1 ENSMUST00000009435.10 ENSMUST00000009435.11 ENSMUST00000009435.2 ENSMUST00000009435.3 ENSMUST00000009435.4 ENSMUST00000009435.5 ENSMUST00000009435.6 ENSMUST00000009435.7 ENSMUST00000009435.8 ENSMUST00000009435.9 NM_145925 PTTG_MOUSE Q3TVT1 Q8BJ96 Q8N7P0 Q8R143 uc007fvx.1 uc007fvx.2 uc007fvx.3 May facilitate PTTG1 nuclear translocation. Interacts with PTTG1. Cell membrane ; Single-pass type I membrane protein Cytoplasm Nucleus Note=May be cytoplasmic and nuclear. p53 binding nucleus nucleoplasm cytoplasm plasma membrane protein import into nucleus membrane integral component of membrane positive regulation of protein ubiquitination negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of cellular protein catabolic process uc007fvx.1 uc007fvx.2 uc007fvx.3 
ENSMUST00000009522.4 Slc16a12 ENSMUST00000009522.4 solute carrier family 16 (monocarboxylic acid transporters), member 12 (from RefSeq NM_172838.4) ENSMUST00000009522.1 ENSMUST00000009522.2 ENSMUST00000009522.3 MOT12_MOUSE Mct12 NM_172838 Q14CF9 Q14DR7 Q8BGC3 Slc16a12 uc008hgu.1 uc008hgu.2 uc008hgu.3 Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution. Reaction=creatine(in) = creatine(out); Xref=Rhea:RHEA:73043, ChEBI:CHEBI:57947; Evidence=; Reaction=guanidinoacetate(in) = guanidinoacetate(out); Xref=Rhea:RHEA:73047, ChEBI:CHEBI:57742; Evidence=; Creatine uptake is inhibited by carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and by valinomycin. Interacts with isoform 2 of BSG; this interaction is required for its localization to the plasma membrane. Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Note=Interaction with isoform 2 of BSG is required for its localization to the plasma membrane. Highly expressed in the lung, liver, kidney, and pancreas (PubMed:26376857). Expressed in eye lens. Expressed in lens at P1 and P7 (PubMed:21778275). The expression levels are higher than in adult lens (PubMed:21778275). Detected in the basolateral membrane of the lens epithelium, with strong staining at equatorial epithelium, and in differentiating secondary fiber cells at P1 (at protein level) (PubMed:21778275). Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. creatine transmembrane transporter activity plasma membrane integral component of plasma membrane monocarboxylic acid transmembrane transporter activity symporter activity monocarboxylic acid transport creatine transport membrane integral component of membrane transmembrane transport uc008hgu.1 uc008hgu.2 uc008hgu.3 
ENSMUST00000009538.12 Syn2 ENSMUST00000009538.12 synapsin II, transcript variant IIa (from RefSeq NM_001111015.1) ENSMUST00000009538.1 ENSMUST00000009538.10 ENSMUST00000009538.11 ENSMUST00000009538.2 ENSMUST00000009538.3 ENSMUST00000009538.4 ENSMUST00000009538.5 ENSMUST00000009538.6 ENSMUST00000009538.7 ENSMUST00000009538.8 ENSMUST00000009538.9 NM_001111015 Q64332 Q6NZR0 Q9QWV7 SYN2_MOUSE uc009din.1 uc009din.2 uc009din.3 uc009din.4 Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons. Can form oligomers with SYN1 (By similarity). Interacts with CAPON. Synapse. Event=Alternative splicing; Named isoforms=2; Name=IIa; IsoId=Q64332-1; Sequence=Displayed; Name=IIb; IsoId=Q64332-2; Sequence=VSP_015203, VSP_015204; Expressed exclusively in neuronal cells. Isoform IIb is enriched in sympathetic cervical ganglion. The A region binds phospholipids with a preference for negatively charged species. Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles (By similarity). Phosphorylation at Ser-426 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons. Belongs to the synapsin family. protein binding ATP binding plasma membrane neurotransmitter secretion synaptic vesicle postsynaptic density calcium ion regulated exocytosis cell junction synaptic vesicle membrane SNARE complex identical protein binding myelin sheath synapse calcium-dependent protein binding synaptic vesicle clustering extrinsic component of synaptic vesicle membrane glutamatergic synapse synaptic vesicle cycle uc009din.1 uc009din.2 uc009din.3 uc009din.4 
ENSMUST00000009550.14 Elk1 ENSMUST00000009550.14 ELK1, member of ETS oncogene family (from RefSeq NM_007922.5) ELK1_MOUSE ENSMUST00000009550.1 ENSMUST00000009550.10 ENSMUST00000009550.11 ENSMUST00000009550.12 ENSMUST00000009550.13 ENSMUST00000009550.2 ENSMUST00000009550.3 ENSMUST00000009550.4 ENSMUST00000009550.5 ENSMUST00000009550.6 ENSMUST00000009550.7 ENSMUST00000009550.8 ENSMUST00000009550.9 Elk1 NM_007922 P41969 Q3V1M9 uc009suc.1 uc009suc.2 uc009suc.3 This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene may produce multiple isoforms by the use of alternative translational start codons. [provided by RefSeq, Mar 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK132354.1, SRR1660815.20528.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript regulatory uORF :: PMID: 22354998 ##RefSeq-Attributes-END## Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (By similarity). Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity). Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity. Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9. Interacts with POU1F1. P41969; P30275: Ckmt1; NbExp=2; IntAct=EBI-15576110, EBI-773103; Nucleus. Predominantly expressed in the brain, and to a lesser extent in the heart, liver and muscle. Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention (By similarity). On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1 but also MAPK8 and/or MAPK9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CaMK4, MAPK11, MAPK12 and MAPK14 (By similarity). Upon bFGF stimulus, phosphorylated by PAK1 (By similarity). Belongs to the ETS family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm mitochondrion regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter response to light stimulus cell differentiation dendrite neuronal cell body sequence-specific DNA binding axon terminus positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cellular response to testosterone stimulus cellular response to lipid cellular response to gamma radiation response to fibroblast growth factor positive regulation of neuron death uc009suc.1 uc009suc.2 uc009suc.3 
ENSMUST00000009679.11 Rnmt ENSMUST00000009679.11 RNA (guanine-7-) methyltransferase, transcript variant 1 (from RefSeq NM_026440.4) ENSMUST00000009679.1 ENSMUST00000009679.10 ENSMUST00000009679.2 ENSMUST00000009679.3 ENSMUST00000009679.4 ENSMUST00000009679.5 ENSMUST00000009679.6 ENSMUST00000009679.7 ENSMUST00000009679.8 ENSMUST00000009679.9 Kiaa0398 MCES_MOUSE NM_026440 Q3V3U9 Q6ZQC6 Q9D0L8 Q9D5F1 uc008fnk.1 uc008fnk.2 uc008fnk.3 Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'- terminal GpppC. Reaction=a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA- COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, ChEBI:CHEBI:167617; EC=2.1.1.56; Evidence= Methyltransferase activity is activated by RAMAC. Interacts with importin alpha, leading to stimulate both RNA- binding and methyltransferase activity. Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates. Interacts with elongating form of polymerase II and RNGTT. Interacts with RAMAC, this interaction significantly enhances RNA-binding and cap methyltransferase activity. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D0L8-1; Sequence=Displayed; Name=2; IsoId=Q9D0L8-2; Sequence=VSP_020243; Name=3; IsoId=Q9D0L8-3; Sequence=VSP_020242; Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family. Sequence=BAC97940.1; Type=Erroneous initiation; Evidence=; fibrillar center RNA binding mRNA (guanine-N7-)-methyltransferase activity nucleus nucleoplasm mRNA cap binding complex 7-methylguanosine mRNA capping mRNA processing methyltransferase activity transferase activity mRNA cap methyltransferase complex methylation receptor complex cellular response to leukemia inhibitory factor uc008fnk.1 uc008fnk.2 uc008fnk.3 
ENSMUST00000009689.11 Kcnq1 ENSMUST00000009689.11 potassium voltage-gated channel, subfamily Q, member 1, transcript variant 1 (from RefSeq NM_008434.3) ENSMUST00000009689.1 ENSMUST00000009689.10 ENSMUST00000009689.2 ENSMUST00000009689.3 ENSMUST00000009689.4 ENSMUST00000009689.5 ENSMUST00000009689.6 ENSMUST00000009689.7 ENSMUST00000009689.8 ENSMUST00000009689.9 KCNQ1_MOUSE Kcna9 Kcnq1 Kvlqt1 NM_008434 O88702 P97414 Q3U4H1 Q7TNZ1 Q7TPL7 Q80VR7 uc009kpb.1 uc009kpb.2 Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity) (PubMed:16314573, PubMed:11120752, PubMed:15004216). Associates with KCNE beta subunits that modulates current kinetics (By similarity) (PubMed:17597584, PubMed:15004216). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) (PubMed:8900282). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:15004216, PubMed:17597584). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (By similarity). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (By similarity). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (PubMed:16314573). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (PubMed:19491250). When associated with KCNE2, forms an heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). When associated with KCNE4, inhibits voltage-gated potassium channel activity (By similarity). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (By similarity). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (By similarity). Binds with phosphatidylinositol 4,5-bisphosphate (By similarity). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo- inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability. Tetramer (By similarity). Heterotetramer with KCNE1; form the native cardiac channel I(Ks) which increases the amplitude and slows down the activation kinetics of outward potassium current and targets to the membrane raft (By similarity) (PubMed:8900282). Interacts (via C-terminus) with CALM; forms a heterooctameric structure (with 4:4 KCNQ1:CALM stoichiometry) in a calcium-independent manner. Interacts with AKAP9; targets protein kinase A (PKA) catalytic and regulatory subunits and protein phosphatase 1 (PP1) to the KCNQ1-KCNE1 complex, allowing PKA-mediated phosphorylation and increase of delayed rectifier potassium channel activity. Interacts with KCNE2; form an heterooligomer complex that targets to the membrane raft and leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current. Interacts with AP2M1; mediates estrogen-induced internalization via clathrin-coated vesicles. Interacts with NEDD4L; promotes internalization and decreases I(Ks) currents. Interacts with USP2; counteracts the NEDD4L-specific down- regulation of I(Ks) and restore plasma membrane localization. Heterotetramer with KCNQ5; has a voltage-gated potassium channel activity. Interacts with KCNE3; alters membrane raft localization. Interacts with KCNE4; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity. Interacts with KCNE5; impairs KCNQ1 localization in lipid rafts and only conducts current upon strong and continued depolarization (By similarity). Interacts with SLC5A3; forms coregulatory channel-transporter complexes that modulate Na(+)-coupled myo-inositol influx through the transporter. Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane Early endosome Membrane raft Endoplasmic reticulum Basolateral cell membrane Apical cell membrane ; Multi-pass membrane protein Note=Colocalized with KCNE3 at the plasma membrane. Upon 17beta-oestradiol treatment, colocalizes with RAB5A at early endosome. Heterotetramer with KCNQ5 is highly retained at the endoplasmic reticulum and is localized outside of lipid raft microdomains. During the early stages of epithelial cell polarization induced by the calcium switch it is removed from the plasma membrane to the endoplasmic reticulum, where it is retained, and redistributed to the basolateral cell surface in a PI3K-dependent manner at a later stage. Colocalizes with SLC5A3 at the apical membrane of choroid plexus epithelium (PubMed:24595108). Event=Alternative splicing; Named isoforms=2; Name=I; IsoId=P97414-1; Sequence=Displayed; Name=II; IsoId=P97414-2; Sequence=VSP_011748, VSP_000983; Expressed in heart, kidney and salivary glands. Detected in the cochlea. Almost undetectable in brain, skeletal muscle and liver. Widely expressed in embryonic and neonatal tissues (PubMed:9618174). Expressed in choroid plexus epithelium (at protein level) (PubMed:24595108). The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The coiled-coil domain mediates tetramerization. The segment S6 is involved in the inhibition of voltage-gated potassium channel activity by KCNE4. The C-terminal assembly domain promotes self-interactiona; allows functional channel. The C-terminal coiled-coil domain interacts with a single CALM molecule via the first two membrane-proximal helical regions, with CALM forming a clamp-like structure. Binding of CALM C-terminus to the first helical region is calcium-independent but is essential for assembly of the structure. Binding of CALM N-terminus to the second helical region is calcium-dependent and regulates electrophysiological activity of the channel. Phosphorylation at Ser-27 by PKA; increases delayed rectifier potassium channel activity of the KCNQ1-KCNE1 complex through a macromolecular complex that includes PKA, PP1, and the targeting protein AKAP9. Ubiquitinated by NEDD4L; promotes internalization. The ubiquitinylated form is internalized through a clathrin-mediated endocytosis by interacting with AP2M1 and is recycled back to the cell membrane via RAB4A and RAB11A. Deubiquitinated by USP2; counteracts the NEDD4L-specific down- regulation of I(Ks) and restores the membrane localization. Mice lacking Kcnq1 show an intestinal absorption impairment which is associated with reduced serum vitamin B12 concentrations, mild macrocytic anemia, and fecal loss of sodium and potassium ions (PubMed:16314573). Mice lacking Kcnq1 show microvillar secretory membranes intact, but basal acid secretion is absent and forskolin-stimulated acid output is reduced by approximately 90% in gastric mucosa (PubMed:19491250). Homozygous Kcnq1 mice develop normally and are viable, demonstrate hyperactivity, circling, and nodding behaviors; exhibit no electrocardiographic abnormalities but present a complete deafness, as well as circular movement and repetitive falling; show severe anatomic disruption of the cochlear and vestibular end organs; also display threefold enlargement by weight of the stomach resulting from mucous neck cell hyperplasia (PubMed:11120752). Mice neonates lacking Kcnq1 display significantly prolonged QT intervals during baseline ECG assessments which significantly increased following isoproterenol challenge; furthermore, the slow delayed rectifier potassium current (IKs) is absent (PubMed:15004216). Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily. Sequence=AAB36518.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity calmodulin binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm lysosome endosome early endosome late endosome endoplasmic reticulum plasma membrane integral component of plasma membrane regulation of gene expression by genetic imprinting ion transport potassium ion transport voltage-gated potassium channel complex protein phosphatase 1 binding positive regulation of heart rate outward rectifier potassium channel activity membrane integral component of membrane basolateral plasma membrane gene silencing cytoplasmic vesicle membrane cytoplasmic vesicle protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding ion channel complex regulation of ion transmembrane transport cellular response to drug sarcolemma regulation of membrane potential zymogen granule membrane protein homodimerization activity ion channel binding membrane raft negative regulation of insulin secretion inner ear development intestinal absorption transmembrane transport cardiac muscle contraction regulation of membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane repolarization positive regulation of cardiac muscle contraction regulation of gastric acid secretion positive regulation of gastric acid secretion renal absorption cellular response to cAMP potassium ion transmembrane transport response to anesthetic cardiovascular system development ventricular cardiac muscle cell action potential voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization membrane repolarization membrane repolarization during action potential membrane repolarization during cardiac muscle cell action potential atrial cardiac muscle cell action potential voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization regulation of heart rate by cardiac conduction scaffold protein binding potassium ion export across plasma membrane membrane repolarization during atrial cardiac muscle cell action potential membrane repolarization during ventricular cardiac muscle cell action potential positive regulation of potassium ion transmembrane transport negative regulation of delayed rectifier potassium channel activity voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization negative regulation of voltage-gated potassium channel activity uc009kpb.1 uc009kpb.2 
ENSMUST00000009693.15 Srp14 ENSMUST00000009693.15 signal recognition particle 14 (from RefSeq NM_009273.4) ENSMUST00000009693.1 ENSMUST00000009693.10 ENSMUST00000009693.11 ENSMUST00000009693.12 ENSMUST00000009693.13 ENSMUST00000009693.14 ENSMUST00000009693.2 ENSMUST00000009693.3 ENSMUST00000009693.4 ENSMUST00000009693.5 ENSMUST00000009693.6 ENSMUST00000009693.7 ENSMUST00000009693.8 ENSMUST00000009693.9 NM_009273 P16254 Q3TIK2 SRP14_MOUSE uc008lsa.1 uc008lsa.2 uc008lsa.3 Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity). Heterodimer with SRP9; binds RNA as heterodimer (By similarity). Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:9233785). Cytoplasm. Belongs to the SRP14 family. RNA binding nucleus cytoplasm signal recognition particle, endoplasmic reticulum targeting SRP-dependent cotranslational protein targeting to membrane 7S RNA binding endoplasmic reticulum signal peptide binding response to drug protein targeting to ER signal recognition particle uc008lsa.1 uc008lsa.2 uc008lsa.3 
ENSMUST00000009699.16 Cdk9 ENSMUST00000009699.16 cyclin dependent kinase 9 (from RefSeq NM_130860.3) B0R020 CDK9_MOUSE ENSMUST00000009699.1 ENSMUST00000009699.10 ENSMUST00000009699.11 ENSMUST00000009699.12 ENSMUST00000009699.13 ENSMUST00000009699.14 ENSMUST00000009699.15 ENSMUST00000009699.2 ENSMUST00000009699.3 ENSMUST00000009699.4 ENSMUST00000009699.5 ENSMUST00000009699.6 ENSMUST00000009699.7 ENSMUST00000009699.8 ENSMUST00000009699.9 NM_130860 Q3U002 Q3UMY2 Q3UPT3 Q3UQI6 Q8BTN0 Q99J95 uc008jgo.1 uc008jgo.2 uc008jgo.3 uc008jgo.4 Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co- transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation. Catalyzes phosphorylation of KAT5, promoting KAT5 recruitment to chromatin and histone acetyltransferase activity. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Reaction=[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho- [DNA-directed RNA polymerase]; Xref=Rhea:RHEA:10216, Rhea:RHEA- COMP:11321, Rhea:RHEA-COMP:11322, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.23; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10217; Evidence=; Activation by Thr-186 phosphorylation is calcium Ca(2+) signaling pathway-dependent; actively inactivated by dephosphorylation mediated by PPP1CA, PPM1A and PPM1B. Reversibly repressed by acetylation at Lys-44 and Lys-48 (By similarity). Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Associates with CCNT1/cyclin-T1, CCNT2/cyclin-T2 (isoform A and isoform B) or CCNK/cyclin-K to form active P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31 and is part of the super elongation complex (SEC). Component of a complex which is composed of at least 5 members: HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin. Associates with UBR5 and forms a transcription regulatory complex composed of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters. Component of the 7SK snRNP inactive complex which is composed of at least 8 members: P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, LARP7, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. This inactive 7SK snRNP complex can also interact with NCOR1 and HDAC3, probably to regulate CDK9 acetylation. Release of P-TEFb from P-TEFb/7SK snRNP complex requires both PP2B to transduce calcium Ca(2+) signaling in response to stimuli (e.g. UV or hexamethylene bisacetamide (HMBA)), and PPP1CA to dephosphorylate Thr-186. This released P-TEFb remains inactive in the pre-initiation complex with BRD4 until new Thr-186 phosphorylation occurs after the synthesis of a short RNA. Interacts with BRD4; to target chromatin binding. Interacts with JMJD6. Interacts with activated nuclear STAT3 and RELA/p65. Binds to AR and MYOD1. Forms a complex composed of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes (By similarity). The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active) (PubMed:22767893). Interacts with HSF1 (By similarity). Interacts with TBX21 (PubMed:27292648). Interacts with WDR43 (PubMed:31128943). Interacts with ZMYND8; the association appears to occur between homodimeric ZMYND8 and the activated form of the P-TEFb complex (By similarity). Q99J95; Q91Y44: Brdt; NbExp=3; IntAct=EBI-2654963, EBI-6260929; Q99J95; P28574: Max; NbExp=2; IntAct=EBI-2654963, EBI-1183003; Q99J95; Q62093: Srsf2; NbExp=3; IntAct=EBI-2654963, EBI-2550402; Nucleus Cytoplasm Nucleus, PML body Note=Accumulates on chromatin in response to replication stress. Complexed with CCNT1 in nuclear speckles, but uncomplexed form in the cytoplasm. The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99J95-1; Sequence=Displayed; Name=2; IsoId=Q99J95-2; Sequence=VSP_016289; Name=3; IsoId=Q99J95-3; Sequence=VSP_016290; Expressed at high levels in brain and kidney. Autophosphorylation at Thr-186, Ser-347, Thr-350, Ser-353, Thr-354 and Ser-357 triggers kinase activity by promoting cyclin and substrate binding upon conformational changes. Thr-186 phosphorylation requires the calcium Ca(2+) signaling pathway, including CaMK1D and calmodulin. This inhibition is relieved by Thr-29 dephosphorylation. Phosphorylation at Ser-175 inhibits kinase activity. Can be phosphorylated on either Thr-362 or Thr-363 but not on both simultaneously (By similarity). Dephosphorylation of Thr-186 by PPM1A and PPM1B blocks CDK9 activity and may lead to CDK9 proteasomal degradation. However, PPP1CA- mediated Thr-186 dephosphorylation is required to release P-TEFb from its inactive P-TEFb/7SK snRNP complex. Dephosphorylation of C-terminus Thr and Ser residues by protein phosphatase-1 (PP1) triggers CDK9 activity (By similarity). N6-acetylation of Lys-44 promotes kinase activity, whereas acetylation of both Lys-44 and Lys-48 mediated by PCAF/KAT2B and GCN5/KAT2A reduces kinase activity. The acetylated form associates with PML bodies in the nuclear matrix and with the transcriptionally silent HIV-1 genome; deacetylated upon transcription stimulation. Deacetylated by SIRT7, promoting the kinase activity and subsequent 'Ser-2' phosphorylation of the C-terminal domain (CTD) of RNA polymerase II. Polyubiquitinated and thus activated by UBR5. This ubiquitination is promoted by TFIIS/TCEA1 and favors 'Ser-2' phosphorylation of RPB1/POLR2A CTD (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Sequence=BAE25966.1; Type=Frameshift; Evidence=; nucleotide binding cyclin-dependent protein kinase holoenzyme complex nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription coactivator binding DNA binding chromatin binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm chromosome cytoplasm DNA repair regulation of DNA repair transcription elongation from RNA polymerase II promoter protein phosphorylation cellular response to DNA damage stimulus transcription elongation factor complex cyclin/CDK positive transcription elongation factor complex transcription factor binding RNA polymerase II carboxy-terminal domain kinase activity positive regulation of cardiac muscle hypertrophy kinase activity phosphorylation PML body transferase activity snRNA binding protein kinase binding cyclin binding regulation of histone modification replication fork processing positive regulation of transcription elongation from RNA polymerase II promoter positive regulation of histone phosphorylation cytoplasmic ribonucleoprotein granule response to drug transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter regulation of muscle cell differentiation phosphorylation of RNA polymerase II C-terminal domain negative regulation of cell cycle arrest cellular response to cytokine stimulus 7SK snRNA binding negative regulation of mRNA polyadenylation positive regulation of mRNA 3'-UTR binding positive regulation of histone H2B ubiquitination uc008jgo.1 uc008jgo.2 uc008jgo.3 uc008jgo.4 
ENSMUST00000009705.14 Eng ENSMUST00000009705.14 endoglin, transcript variant 1 (from RefSeq NM_007932.2) EGLN_MOUSE ENSMUST00000009705.1 ENSMUST00000009705.10 ENSMUST00000009705.11 ENSMUST00000009705.12 ENSMUST00000009705.13 ENSMUST00000009705.2 ENSMUST00000009705.3 ENSMUST00000009705.4 ENSMUST00000009705.5 ENSMUST00000009705.6 ENSMUST00000009705.7 ENSMUST00000009705.8 ENSMUST00000009705.9 Edg NM_007932 Q61520 Q63961 Q8K100 uc008jgk.1 uc008jgk.2 uc008jgk.3 uc008jgk.4 Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:10625534). Required for normal structure and integrity of adult vasculature (By similarity). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (PubMed:10625534). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (PubMed:28530658). May play a role in the binding of endothelial cells to integrins. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity). Homodimer; disulfide-linked (PubMed:8194490). Forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. Interacts with TGFB1 (PubMed:8194490). It is able to bind TGFB1 and TGFB2 with high affinity, but not TGFB3. Interacts with GDF2, forming a heterotetramer with a 2:2 stoichiometry. Interacts with ACVRL1. Can form a heteromeric complex with GDF2 and ACVRL1. Interacts with BMP10. Interacts with DYNLT4. Interacts with ARRB2. Cell membrane ; Single-pass type I membrane protein Detected on blood vessels (at protein level) (PubMed:8194490). Detected on adult pulmonary artery, capillaries supporting the heart muscle and lung alveolar capillary endothelial cells (PubMed:10625534). Endoglin is restricted to endothelial cells in all tissues except bone marrow and is also found in stromal cells within the connective tissue of intestine, stomach, heart, skeletal muscle, uterus, ovary, oviduct, testis and thymus (PubMed:8194490). Detected in embryo (at protein level). Detected in endothelium from yolk sac vessels. The ZP domain mediates dimerization. The N-terminal OR region is composed of two intertwined domains (OR1 and OR2) with a common, novel fold. Each contains 12 beta-strands that form a parallel beta-helix-like structure, plus a single alpha- helix. The OR1 region mediates interaction with GDF2. Full embryonic lethality at about 10.5 dpc. At 9.5 dpc, embryos display abnormal yolk sac vasculature and yolk sac anemia. Mutant embryos are also anemic, probably due to defective hematopoiesis in the yolk sac. In contrast, the embryonic vasculature appears grossly normal in most cases, but heart development is abnormal, and nearly all mutant embryos had enlarged ventricles and dilated outflow tracts. Besides, many had abnormal cardiac looping and displayed pericardial effusion. Heterozygous mice have occasionally abnormally convoluted and dilated blood vessels with disorganized smooth muscle cells surrounding them; these blood vessels are very fragile and rupture easily. Lacks a RGD motif, contrary to the human protein. negative regulation of transcription from RNA polymerase II promoter chronological cell aging angiogenesis branching involved in blood vessel morphogenesis vasculogenesis response to hypoxia positive regulation of protein phosphorylation negative regulation of endothelial cell proliferation heart looping positive regulation of systemic arterial blood pressure outflow tract septum morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis cell migration involved in endocardial cushion formation transforming growth factor beta-activated receptor activity transforming growth factor beta receptor, cytoplasmic mediator activity type II transforming growth factor beta receptor binding protein binding galactose binding glycosaminoglycan binding extracellular space plasma membrane regulation of transcription, DNA-templated cell adhesion transforming growth factor beta receptor signaling pathway heart development external side of plasma membrane cell surface positive regulation of gene expression negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation membrane integral component of membrane cell migration regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis extracellular matrix disassembly negative regulation of cell migration positive regulation of BMP signaling pathway negative regulation of protein autophosphorylation positive regulation of collagen biosynthetic process type I transforming growth factor beta receptor binding dorsal aorta morphogenesis BMP binding wound healing identical protein binding protein homodimerization activity receptor complex positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis cell motility transforming growth factor beta binding negative regulation of nitric-oxide synthase activity positive regulation of protein kinase B signaling atrial cardiac muscle tissue morphogenesis cell chemotaxis negative regulation of pathway-restricted SMAD protein phosphorylation extracellular matrix constituent secretion detection of hypoxia endothelial microparticle vascular smooth muscle cell development positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of vascular smooth muscle cell differentiation atrioventricular canal morphogenesis sprouting angiogenesis regulation of cardiac muscle cell apoptotic process endocardial cushion to mesenchymal transition cardiac jelly development regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis regulation of cell proliferation involved in heart morphogenesis uc008jgk.1 uc008jgk.2 uc008jgk.3 uc008jgk.4 
ENSMUST00000009707.14 Tor2a ENSMUST00000009707.14 torsin family 2, member A, transcript variant 14 (from RefSeq NR_178212.1) ENSMUST00000009707.1 ENSMUST00000009707.10 ENSMUST00000009707.11 ENSMUST00000009707.12 ENSMUST00000009707.13 ENSMUST00000009707.2 ENSMUST00000009707.3 ENSMUST00000009707.4 ENSMUST00000009707.5 ENSMUST00000009707.6 ENSMUST00000009707.7 ENSMUST00000009707.8 ENSMUST00000009707.9 NR_178212 Q3TBH0 Q3TC01 Q3V4D1 Q8R1J9 Q8R5B5 TOR2A_MOUSE uc008jgt.1 uc008jgt.2 uc008jgt.3 Homohexamer. Interacts with TOR1AIP1. Endoplasmic reticulum lumen Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R1J9-1; Sequence=Displayed; Name=2; IsoId=Q8R1J9-2; Sequence=VSP_017705; Name=3; IsoId=P0C7W3-1; Sequence=External; Expressed at similar levels in liver, muscle and brain (at protein level). At 16 dpc, widely expressed in all tissues tested. N-glycosylated. Belongs to the ClpA/ClpB family. Torsin subfamily. nucleotide binding protein binding ATP binding nuclear envelope endoplasmic reticulum endoplasmic reticulum lumen ATPase activity identical protein binding chaperone mediated protein folding requiring cofactor uc008jgt.1 uc008jgt.2 uc008jgt.3 
ENSMUST00000009727.12 Syngr1 ENSMUST00000009727.12 synaptogyrin 1, transcript variant 1a (from RefSeq NM_207708.2) B9EI16 ENSMUST00000009727.1 ENSMUST00000009727.10 ENSMUST00000009727.11 ENSMUST00000009727.2 ENSMUST00000009727.3 ENSMUST00000009727.4 ENSMUST00000009727.5 ENSMUST00000009727.6 ENSMUST00000009727.7 ENSMUST00000009727.8 ENSMUST00000009727.9 NM_207708 O55100 Q543Y5 Q9DCB0 SNG1_MOUSE Syngr1 uc007wvd.1 uc007wvd.2 uc007wvd.3 May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (PubMed:10595519). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Melanosome Event=Alternative splicing; Named isoforms=2; Name=1A; IsoId=O55100-1; Sequence=Displayed; Name=1B; IsoId=O55100-2; Sequence=VSP_006333; Mice lacking both Syngr1 and Syp show normal brain structure and composition, but impaired short-term and long-term synaptic plasticity. Belongs to the synaptogyrin family. protein targeting synaptic vesicle membrane integral component of membrane cell junction integral component of synaptic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle neuromuscular junction melanosome regulated exocytosis synapse regulation of long-term neuronal synaptic plasticity regulation of short-term neuronal synaptic plasticity synaptic vesicle membrane organization cellular response to leukemia inhibitory factor uc007wvd.1 uc007wvd.2 uc007wvd.3 
ENSMUST00000009732.8 St6galnac1 ENSMUST00000009732.8 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (from RefSeq NM_011371.2) A2AA23 ENSMUST00000009732.1 ENSMUST00000009732.2 ENSMUST00000009732.3 ENSMUST00000009732.4 ENSMUST00000009732.5 ENSMUST00000009732.6 ENSMUST00000009732.7 NM_011371 Q9JJP5 Q9QZ39 SIA7A_MOUSE Siat7a St6galnac1 uc007mme.1 uc007mme.2 Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis (PubMed:35303419). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins (PubMed:10788794). Catalyzes the formation of the sialyl-Tn (S-Tn) antigen, an antigen found in intestinal goblet cells (PubMed:35303419). Protein sialylation in globlet cells is essential for mucus integrity and is required to protect the intestinal mucus against excessive bacterial proteolytic degradation (PubMed:35303419). Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl- (1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D- galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:11136, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133470, ChEBI:CHEBI:140764; EC=2.4.3.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11137; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein Submaxillary gland, mammary gland, spleen and colon. Glycosylated; autosialylated. Belongs to the glycosyltransferase 29 family. Name=Functional Glycomics Gateway - GTase; Note=ST6GalNAc I; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_650"; Golgi membrane ganglioside biosynthetic process alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Golgi apparatus protein glycosylation sialyltransferase activity oligosaccharide biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups sialylation uc007mme.1 uc007mme.2 
ENSMUST00000009772.8 Tex15 ENSMUST00000009772.8 testis expressed gene 15 meiosis and synapsis associated (from RefSeq NM_031374.2) ENSMUST00000009772.1 ENSMUST00000009772.2 ENSMUST00000009772.3 ENSMUST00000009772.4 ENSMUST00000009772.5 ENSMUST00000009772.6 ENSMUST00000009772.7 F8VPN2 NM_031374 Q3UPQ6 Q3V162 Q99MV3 TEX15_MOUSE Tex15 uc009lkc.1 uc009lkc.2 uc009lkc.3 Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair (PubMed:18283110). Essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (PubMed:32381626, PubMed:32719317). PIWIL4-piRNA binds to nascent transposon transcripts and interacts with TEX15, which may in turn recruit the epigenetic silencing machinery to the transposon loci (PubMed:32381626). Not required for piRNA biosynthesis (PubMed:32381626, PubMed:32719317). Interacts with PIWIL4 (PubMed:32719317). Interacts with PIWIL2 (PubMed:32381626). Cytoplasm cleus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=F8VPN2-1; Sequence=Displayed; Name=2 ; IsoId=F8VPN2-2; Sequence=VSP_058101; Detected in testis and ovary, and at lower levels in lung and brain. Highly expressed in embryonic male germ cells at embryonic days 16.5 dpc and 18.5 dpc and expression increases at postnatal day 2.5. Viable with no gross phenotype. Male mice are infertile with significantly reduced testis size, while females are fertile. Severe depletion of germ cells in seminiferous tubules and epididymal tubules, due to meiotic arrest (PubMed:18283110, PubMed:32381626, PubMed:32719317). Male germ cells show derepression of transposable elements (TEs) and severe DNA hypomethylation of TEs (PubMed:32381626, PubMed:32719317). Belongs to the TEX15 family. molecular_function cellular_component nucleus cytoplasm DNA repair cellular response to DNA damage stimulus synapsis synaptonemal complex assembly male meiosis spermatogenesis fertilization regulation of double-strand break repair via homologous recombination cell differentiation male genitalia development regulation of protein localization protein localization to chromosome homeostasis of number of cells within a tissue meiotic cell cycle uc009lkc.1 uc009lkc.2 uc009lkc.3 
ENSMUST00000009774.11 Ppp2cb ENSMUST00000009774.11 protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform, transcript variant 1 (from RefSeq NM_017374.4) ENSMUST00000009774.1 ENSMUST00000009774.10 ENSMUST00000009774.2 ENSMUST00000009774.3 ENSMUST00000009774.4 ENSMUST00000009774.5 ENSMUST00000009774.6 ENSMUST00000009774.7 ENSMUST00000009774.8 ENSMUST00000009774.9 NM_017374 P11082 P62715 PP2AB_MOUSE uc009lkd.1 uc009lkd.2 uc009lkd.3 Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20630; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47005; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGO1, most probably through regulatory B56 subunits. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD. Interacts with CTTNBP2NL. Interacts with PTPA. Cytoplasm. Nucleus Chromosome, centromere Cytoplasm, cytoskeleton, spindle pole Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles (By similarity). Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (Lcmt1) and protein phosphatase methylesterase 1 (Ppme1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity). Phosphorylation of either threonine (by autophosphorylation- activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation (By similarity). May be monoubiquitinated by NOSIP. Belongs to the PPP phosphatase family. PP-1 subfamily. protein phosphatase type 2A complex chromosome, centromeric region spindle pole phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein binding nucleus chromosome cytoplasm cytosol cytoskeleton protein dephosphorylation protein C-terminus binding apoptotic mitochondrial changes response to lead ion regulation of gene expression hydrolase activity response to endoplasmic reticulum stress response to hydrogen peroxide proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of Ras protein signal transduction response to antibiotic metal ion binding positive regulation of microtubule binding uc009lkd.1 uc009lkd.2 uc009lkd.3 
ENSMUST00000009777.4 G0s2 ENSMUST00000009777.4 G0/G1 switch gene 2 (from RefSeq NM_008059.3) ENSMUST00000009777.1 ENSMUST00000009777.2 ENSMUST00000009777.3 G0S2_MOUSE NM_008059 Q61585 uc007eei.1 uc007eei.2 uc007eei.3 uc007eei.4 Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex. Mitochondrion mitochondrion apoptotic process extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway uc007eei.1 uc007eei.2 uc007eei.3 uc007eei.4 
ENSMUST00000009789.15 P4ha1 ENSMUST00000009789.15 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide, transcript variant 3 (from RefSeq NM_011030.2) ENSMUST00000009789.1 ENSMUST00000009789.10 ENSMUST00000009789.11 ENSMUST00000009789.12 ENSMUST00000009789.13 ENSMUST00000009789.14 ENSMUST00000009789.2 ENSMUST00000009789.3 ENSMUST00000009789.4 ENSMUST00000009789.5 ENSMUST00000009789.6 ENSMUST00000009789.7 ENSMUST00000009789.8 ENSMUST00000009789.9 NM_011030 P4HA1_MOUSE Q3TEB7 Q60715 Q80T05 Q91VJ7 uc007fdo.1 uc007fdo.2 uc007fdo.3 Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Reaction=2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]; Xref=Rhea:RHEA:18945, Rhea:RHEA- COMP:11676, Rhea:RHEA-COMP:11680, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50342, ChEBI:CHEBI:61965; EC=1.14.11.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18946; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit.; Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Inhibited by poly(L-proline). Kinetic parameters: KM=22 uM for 2-oxoglutarate ; Heterotetramer of two alpha-1 chains and two beta chains (P4HB)(the beta chain is the multi-functional PDI), where P4HB plays the role of a structural subunit; this tetramer catalyzes the formation of 4-hydroxyproline in collagen. Endoplasmic reticulum lumen. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60715-1; Sequence=Displayed; Name=2; Synonyms=alpha(I) ; IsoId=Q60715-2; Sequence=VSP_004505; Expressed at least in brain, heart and lung. Belongs to the P4HA family. procollagen-proline 4-dioxygenase activity iron ion binding mitochondrion endoplasmic reticulum endoplasmic reticulum lumen procollagen-proline 4-dioxygenase complex oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen peptidyl-proline hydroxylation to 4-hydroxy-L-proline collagen fibril organization L-ascorbic acid binding identical protein binding intracellular membrane-bounded organelle metal ion binding dioxygenase activity oxidation-reduction process uc007fdo.1 uc007fdo.2 uc007fdo.3 
ENSMUST00000009790.14 Pla2g12b ENSMUST00000009790.14 phospholipase A2, group XIIB (from RefSeq NM_023530.2) ENSMUST00000009790.1 ENSMUST00000009790.10 ENSMUST00000009790.11 ENSMUST00000009790.12 ENSMUST00000009790.13 ENSMUST00000009790.2 ENSMUST00000009790.3 ENSMUST00000009790.4 ENSMUST00000009790.5 ENSMUST00000009790.6 ENSMUST00000009790.7 ENSMUST00000009790.8 ENSMUST00000009790.9 NM_023530 Pla2g12b Q8VC81 Q8VC81_MOUSE uc007fdq.1 uc007fdq.2 uc007fdq.3 phospholipase A2 activity calcium ion binding extracellular region phospholipid metabolic process lipid catabolic process hydrolase activity arachidonic acid secretion uc007fdq.1 uc007fdq.2 uc007fdq.3 
ENSMUST00000009798.5 Oit3 ENSMUST00000009798.5 oncoprotein induced transcript 3 (from RefSeq NM_010959.2) ENSMUST00000009798.1 ENSMUST00000009798.2 ENSMUST00000009798.3 ENSMUST00000009798.4 Lzp NM_010959 OIT3_MOUSE P97806 Q811T0 Q8C9U1 Q8R4V5 uc007fdr.1 uc007fdr.2 uc007fdr.3 May be involved in hepatocellular function and development. Nucleus envelope Note=Secreted into blood in a truncated form. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R4V5-1; Sequence=Displayed; Name=2; IsoId=Q8R4V5-2; Sequence=VSP_027484; Liver-specific. Expressed only in the hepatocytes. Expression begins as early as 6.5 dpc and very early in fetal liver (at least from 11.5 dpc). Expression level changes in different developmental stages. Levels decrease to a minimal level at 17.5 dpc and then increase gradually to the maximal level at about 7 days after birth. calcium ion binding nucleus nuclear envelope urate homeostasis uc007fdr.1 uc007fdr.2 uc007fdr.3 
ENSMUST00000009875.5 Kcnd1 ENSMUST00000009875.5 potassium voltage-gated channel, Shal-related family, member 1 (from RefSeq NM_008423.2) ENSMUST00000009875.1 ENSMUST00000009875.2 ENSMUST00000009875.3 ENSMUST00000009875.4 KCND1_MOUSE NM_008423 Q03719 Q8CC68 uc009sms.1 uc009sms.2 uc009sms.3 uc009sms.4 This gene encodes a multipass transmembrane protein that comprises a subunit of voltage-gated rapidly inactivating A-type potassium channels. [provided by RefSeq, May 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK033805.1, SRR1660819.7259.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in the heart and I(Sa) current in neurons. Channel properties are modulated by subunit assembly. Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Interacts with DPP10 (By similarity). Membrane; Multi-pass membrane protein. Cell projection, dendrite The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity A-type (transient outward) potassium channel activity potassium channel activity ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane dendrite regulation of ion transmembrane transport cell projection neuronal cell body metal ion binding protein homooligomerization transmembrane transport potassium ion transmembrane transport uc009sms.1 uc009sms.2 uc009sms.3 uc009sms.4 
ENSMUST00000010007.9 Sdhb ENSMUST00000010007.9 succinate dehydrogenase complex, subunit B, iron sulfur (Ip), transcript variant 1 (from RefSeq NM_023374.4) ENSMUST00000010007.1 ENSMUST00000010007.2 ENSMUST00000010007.3 ENSMUST00000010007.4 ENSMUST00000010007.5 ENSMUST00000010007.6 ENSMUST00000010007.7 ENSMUST00000010007.8 NM_023374 Q3TF82 Q9CQA3 Q9DC91 SDHB_MOUSE uc008vnl.1 uc008vnl.2 uc008vnl.3 uc008vnl.4 Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Reaction=a quinone + succinate = a quinol + fumarate; Xref=Rhea:RHEA:40523, ChEBI:CHEBI:24646, ChEBI:CHEBI:29806, ChEBI:CHEBI:30031, ChEBI:CHEBI:132124; EC=1.3.5.1; Evidence=; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 1 [2Fe-2S] cluster. ; Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137; Evidence=; Note=Binds 1 [3Fe-4S] cluster. ; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (By similarity). Interacts with SDHAF1; the interaction is required for iron-sulfur cluster incorporation into SDHB (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. nucleoplasm mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) plasma membrane tricarboxylic acid cycle succinate metabolic process succinate dehydrogenase (ubiquinone) activity electron carrier activity aerobic respiration membrane oxidoreductase activity respiratory electron transport chain mitochondrial membrane respiratory chain complex II metal ion binding ubiquinone binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding 3 iron, 4 sulfur cluster binding 4 iron, 4 sulfur cluster binding oxidation-reduction process uc008vnl.1 uc008vnl.2 uc008vnl.3 uc008vnl.4 
ENSMUST00000010020.12 Cox4i2 ENSMUST00000010020.12 cytochrome c oxidase subunit 4I2 (from RefSeq NM_053091.2) COX42_MOUSE Cox4b ENSMUST00000010020.1 ENSMUST00000010020.10 ENSMUST00000010020.11 ENSMUST00000010020.2 ENSMUST00000010020.3 ENSMUST00000010020.4 ENSMUST00000010020.5 ENSMUST00000010020.6 ENSMUST00000010020.7 ENSMUST00000010020.8 ENSMUST00000010020.9 NM_053091 Q91W29 uc008ngg.1 uc008ngg.2 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Energy metabolism; oxidative phosphorylation. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the cytochrome c oxidase IV family. cytochrome-c oxidase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex IV mitochondrial electron transport, cytochrome c to oxygen membrane mitochondrial membrane cellular response to hypoxia hydrogen ion transmembrane transport uc008ngg.1 uc008ngg.2 
ENSMUST00000010038.10 Snap47 ENSMUST00000010038.10 synaptosomal-associated protein, 47, transcript variant 2 (from RefSeq NM_144521.3) ENSMUST00000010038.1 ENSMUST00000010038.2 ENSMUST00000010038.3 ENSMUST00000010038.4 ENSMUST00000010038.5 ENSMUST00000010038.6 ENSMUST00000010038.7 ENSMUST00000010038.8 ENSMUST00000010038.9 NM_144521 Q3UNK4 Q8BK87 Q8R570 SNP47_MOUSE uc007jds.1 uc007jds.2 uc007jds.3 May play a role in intracellular membrane fusion. Associates with the BLOC-1 complex. Interacts with BLOC1S6 (By similarity). Forms a complex containing SNAP47, VAMP2 and STX1A. Endomembrane system Cytoplasm, perinuclear region Note=Appears to be exclusively membrane- bound. In primary neurons, widely distributed in both cell bodies and neuronal processes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R570-1; Sequence=Displayed; Name=2; IsoId=Q8R570-2; Sequence=VSP_028615, VSP_028616; Ubiquitously expressed with the most abundant expression in the brain. In brain, most highly expressed in the glomerular layer of the olfactory bulb, the cortex, striatum, hippocampus, and colliculi (at protein level). Expressed as early as 10 dpc in developing brain and reaches maximal levels at 18 dpc. Belongs to the SVAP1 family. Sequence=BAC35874.1; Type=Frameshift; Evidence=; SNAP receptor activity cytoplasm plasma membrane exocytosis vesicle fusion endomembrane system postsynaptic density membrane synaptic vesicle priming syntaxin binding dendrite synaptic vesicle membrane BLOC-1 complex SNARE complex synaptic vesicle fusion to presynaptic active zone membrane asymmetric synapse neuronal cell body perinuclear region of cytoplasm long-term synaptic potentiation exocytic insertion of neurotransmitter receptor to postsynaptic membrane glutamatergic synapse vesicle-mediated transport in synapse uc007jds.1 uc007jds.2 uc007jds.3 
ENSMUST00000010044.8 Wnt3a ENSMUST00000010044.8 wingless-type MMTV integration site family, member 3A (from RefSeq NM_009522.3) ENSMUST00000010044.1 ENSMUST00000010044.2 ENSMUST00000010044.3 ENSMUST00000010044.4 ENSMUST00000010044.5 ENSMUST00000010044.6 ENSMUST00000010044.7 NM_009522 P27467 WNT3A_MOUSE Wnt-3a uc007jdp.1 uc007jdp.2 uc007jdp.3 uc007jdp.4 uc007jdp.5 Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites (PubMed:8299937). Required for normal morphogenesis of the developing neural tube (PubMed:8299937). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720). Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Homooligomer; disulfide-linked, leading to inactivation (PubMed:25771893). Interacts with APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6 (By similarity). Interacts with PORCN (PubMed:10866835). Interacts with glypican GPC3 (By similarity). Interacts with PKD1 (via extracellular domain) (By similarity). P27467; Q61091: Fzd8; NbExp=7; IntAct=EBI-2899665, EBI-6171689; P27467; E9Q612: Ptpro; NbExp=2; IntAct=EBI-2899665, EBI-8183885; P27467; P27467: Wnt3a; NbExp=2; IntAct=EBI-2899665, EBI-2899665; P27467; G3MYZ3: AFM; Xeno; NbExp=3; IntAct=EBI-2899665, EBI-22052138; P27467; P43652: AFM; Xeno; NbExp=3; IntAct=EBI-2899665, EBI-20737924; P27467; O75581: LRP6; Xeno; NbExp=4; IntAct=EBI-2899665, EBI-910915; P27467; A6NFA1: TRABD2B; Xeno; NbExp=2; IntAct=EBI-2899665, EBI-6257471; P27467; Q9Y5W5: WIF1; Xeno; NbExp=8; IntAct=EBI-2899665, EBI-3922719; Secreted, extracellular space, extracellular matrix Secreted Dorsal portion of the neural tube (developing roof plate), and mesenchyme tissue surrounding the umbilical veins. Detected in the dorsal primitive streak region at 8.5 dpc. Detected in the tailbud region and in the developing central nervous system (CNS) at 9.5 dpc. Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT3A. Disulfide bonds have critical and distinct roles in secretion and activity. Loss of each conserved cysteine in WNT3A results in high molecular weight oxidized Wnt oligomers, which are formed through inter-Wnt disulfide bonding. Palmitoleoylation by PORCN is required for efficient binding to frizzled receptors. Palmitoleoylation is required for proper trafficking to cell surface, vacuolar acidification is critical to release palmitoleoylated WNT3A from WLS in secretory vesicles (PubMed:17141155, PubMed:24798332). Depalmitoleoylated by NOTUM, leading to inhibit Wnt signaling pathway, possibly by promoting disulfide bond formation and oligomerization (PubMed:25771893). Gene targeting that leads to the production of a truncated mRNA causes full embryonic lethality at 10.5 to 12.5 dpc. Belongs to the Wnt family. The formation of disulfide-linked oligomers may be an artifact that occurs upon heterologous expression in vitro (PubMed:25771893, PubMed:26902720). Formation of disulfide-linked oligomers is not observed when the protein is coexpressed with AFM (PubMed:26902720). A palmitoylation site was proposed at Cys-77, but it was later shown that this cysteine is engaged in a disulfide bond. osteoblast differentiation in utero embryonic development somitogenesis positive regulation of cytokine production positive regulation of protein phosphorylation heart looping positive regulation of receptor internalization negative regulation of heart induction by canonical Wnt signaling pathway transcription coactivator activity receptor binding frizzled binding protein binding extracellular region extracellular space endoplasmic reticulum lumen signal transduction cell-cell signaling multicellular organism development determination of left/right symmetry axonogenesis axon guidance mesoderm development cell proliferation positive regulation of cell proliferation animal organ morphogenesis anterior/posterior pattern specification cell surface COP9 signalosome assembly positive regulation of gene expression negative regulation of neuron projection development Wnt signaling pathway protein domain specific binding spinal cord association neuron differentiation hippocampus development cell proliferation in forebrain Wnt signaling pathway involved in forebrain neuroblast division dorsal/ventral neural tube patterning neurogenesis hemopoiesis platelet activation neuron differentiation extracellular matrix organization BMP signaling pathway mammary gland development positive regulation of B cell proliferation midbrain development positive regulation of protein binding positive regulation of peptidyl-serine phosphorylation cell proliferation in midbrain cellular protein localization skeletal muscle cell differentiation post-anal tail morphogenesis co-receptor binding inner ear morphogenesis positive regulation of cysteine-type endopeptidase activity involved in apoptotic process cell fate commitment synapse regulation of cell differentiation negative regulation of fat cell differentiation positive regulation of protein kinase activity positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter receptor agonist activity somatic stem cell division positive regulation of mesodermal cell fate specification paraxial mesodermal cell fate commitment positive regulation of skeletal muscle tissue development positive regulation of collateral sprouting in absence of injury negative regulation of axon extension involved in axon guidance negative regulation of neurogenesis regulation of axonogenesis modulation of synaptic transmission regulation of synapse organization positive regulation of sequence-specific DNA binding transcription factor activity canonical Wnt signaling pathway cardiac muscle cell fate commitment positive regulation of protein tyrosine kinase activity positive regulation of dermatome development canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment regulation of microtubule cytoskeleton organization platelet aggregation dopaminergic neuron differentiation axis elongation involved in somitogenesis positive regulation of canonical Wnt signaling pathway calcium ion transmembrane transport via low voltage-gated calcium channel glutamatergic synapse postsynapse to nucleus signaling pathway negative regulation of neuron death positive regulation of protein localization to plasma membrane negative regulation of dopaminergic neuron differentiation positive regulation of core promoter binding regulation of presynapse assembly Wnt-Frizzled-LRP5/6 complex Wnt signalosome positive regulation of cell-cell adhesion mediated by cadherin positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation positive regulation of neural precursor cell proliferation positive regulation of hepatocyte proliferation positive regulation of cardiac muscle cell differentiation regulation of RNA biosynthetic process uc007jdp.1 uc007jdp.2 uc007jdp.3 uc007jdp.4 uc007jdp.5 
ENSMUST00000010049.6 Kdsr ENSMUST00000010049.6 3-ketodihydrosphingosine reductase, transcript variant 1 (from RefSeq NM_027534.2) ENSMUST00000010049.1 ENSMUST00000010049.2 ENSMUST00000010049.3 ENSMUST00000010049.4 ENSMUST00000010049.5 Fvt1 Kdsr NM_027534 Q8CII3 Q8CII3_MOUSE uc007cgy.1 uc007cgy.2 uc007cgy.3 uc007cgy.4 Reaction=NADP(+) + sphinganine = 3-oxosphinganine + H(+) + NADPH; Xref=Rhea:RHEA:22640, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57817, ChEBI:CHEBI:58299, ChEBI:CHEBI:58349; EC=1.1.1.102; Evidence=; Lipid metabolism; sphingolipid metabolism. Sphingolipid metabolism. Belongs to the short-chain dehydrogenases/reductases (SDR) family. endoplasmic reticulum 3-keto-sphinganine metabolic process oxidoreductase activity 3-dehydrosphinganine reductase activity oxidation-reduction process uc007cgy.1 uc007cgy.2 uc007cgy.3 uc007cgy.4 
ENSMUST00000010085.4 Nxf2 ENSMUST00000010085.4 nuclear RNA export factor 2, transcript variant 1 (from RefSeq NM_001289735.1) ENSMUST00000010085.1 ENSMUST00000010085.2 ENSMUST00000010085.3 NM_001289735 NXF2 Nxf2 Q4ZGD8 Q4ZGD8_MOUSE uc009ugv.1 uc009ugv.2 uc009ugv.3 uc009ugv.4 Belongs to the NXF family. nucleic acid binding RNA binding mRNA binding protein binding nucleus nuclear envelope cytoplasm RNA export from nucleus mRNA export from nucleus poly(A)+ mRNA export from nucleus mRNA transport uc009ugv.1 uc009ugv.2 uc009ugv.3 uc009ugv.4 
ENSMUST00000010127.12 Tktl1 ENSMUST00000010127.12 transketolase-like 1 (from RefSeq NM_031379.2) B1AYP0 ENSMUST00000010127.1 ENSMUST00000010127.10 ENSMUST00000010127.11 ENSMUST00000010127.2 ENSMUST00000010127.3 ENSMUST00000010127.4 ENSMUST00000010127.5 ENSMUST00000010127.6 ENSMUST00000010127.7 ENSMUST00000010127.8 ENSMUST00000010127.9 NM_031379 Q684Q5 Q8CDU7 Q99MX0 TKTL1_MOUSE Tktl1 uc009tnx.1 uc009tnx.2 uc009tnx.3 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Reaction=D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate; Xref=Rhea:RHEA:10508, ChEBI:CHEBI:57483, ChEBI:CHEBI:57737, ChEBI:CHEBI:58273, ChEBI:CHEBI:59776; EC=2.2.1.1; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:10510; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). ; Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Note=Binds 1 thiamine pyrophosphate per subunit. ; Homodimer. Cytoplasm Not expressed in the embryonic neocortex. Belongs to the transketolase family. catalytic activity transketolase activity cellular_component nucleus cytoplasm transferase activity metal ion binding uc009tnx.1 uc009tnx.2 uc009tnx.3 
ENSMUST00000010188.9 Zmynd10 ENSMUST00000010188.9 zinc finger, MYND domain containing 10, transcript variant 1 (from RefSeq NM_053253.4) Blu ENSMUST00000010188.1 ENSMUST00000010188.2 ENSMUST00000010188.3 ENSMUST00000010188.4 ENSMUST00000010188.5 ENSMUST00000010188.6 ENSMUST00000010188.7 ENSMUST00000010188.8 NM_053253 Q3V1P0 Q80W73 Q99ML0 ZMY10_MOUSE uc009rlo.1 uc009rlo.2 uc009rlo.3 Plays a role in axonemal structure organization and motility (PubMed:29601588). Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (PubMed:29601588). May act by indirectly regulating transcription of dynein proteins (By similarity). Interacts (via C-terminus) with DNAAF11 (via CS domain); this interaction stabilizes DNAAF11 at the protein level. Interacts (via C- terminus) with DNAL1; this interaction stabilizes DNAL1 at the protein level. Interacts with DNAAF4, HSPA8, IQUB, RUVBL2 and DYNTL5. Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Apical cell membrane Dynein axonemal particle Expressed in the testis. Expressed in the tracheal epithelium (PubMed:29601588). Restricted to regions containing motile cilia (PubMed:23891471). Specifically expressed in the ciliated epithelial layer associated with nasal and lung epithelium in 18.5 dpc embryos. Mice neonates exhibit growth retardation dying within 1 month after birth. Show head deformation and situs invertus (heart apex, stomach, liver or spleen). Display lung lobular structures deterioration and collapsed alveolar spaces. Show mucosal congestion in paranasal cavities. Show loss of ciliary motility and axonemal outer and inner dynein arm (IDA and ODA, respectively) components without disruption of ciliogenesis. Belongs to the ZMYND10 family. molecular_function cytoplasm microtubule organizing center cytoskeleton plasma membrane membrane apical plasma membrane centriolar satellite outer dynein arm assembly inner dynein arm assembly motile cilium assembly metal ion binding positive regulation of motile cilium assembly uc009rlo.1 uc009rlo.2 uc009rlo.3 
ENSMUST00000010189.3 Tmem115 ENSMUST00000010189.3 transmembrane protein 115 (from RefSeq NM_019704.2) ENSMUST00000010189.1 ENSMUST00000010189.2 NM_019704 Pl6 Q91VT6 Q9WUH1 TM115_MOUSE Tmem115 uc009rlk.1 uc009rlk.2 uc009rlk.3 May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. Homooligomer. Interacts with COPB1. May interact with LMAN1. Interacts with the COG complex; probably through COG3. Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein Belongs to the TMEM115 family. Sequence=AAH09099.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function nucleus Golgi apparatus protein glycosylation retrograde vesicle-mediated transport, Golgi to ER membrane integral component of membrane Golgi transport complex Golgi cisterna membrane identical protein binding uc009rlk.1 uc009rlk.2 uc009rlk.3 
ENSMUST00000010192.11 Ifrd2 ENSMUST00000010192.11 interferon-related developmental regulator 2 (from RefSeq NM_025903.2) ENSMUST00000010192.1 ENSMUST00000010192.10 ENSMUST00000010192.2 ENSMUST00000010192.3 ENSMUST00000010192.4 ENSMUST00000010192.5 ENSMUST00000010192.6 ENSMUST00000010192.7 ENSMUST00000010192.8 ENSMUST00000010192.9 IFRD2_MOUSE Ifrd2 NM_025903 Q7TSB3 Q9CW96 Q9D8U0 uc009rmd.1 uc009rmd.2 uc009rmd.3 Ribosome-binding protein that acts as an inhibitor of mRNA translation by promoting ribosome inactivation (By similarity). Associates with the P- and E-sites of the ribosome and inserts a C- terminal helix into the mRNA exit channel to preclude translation (By similarity). Associates with ribosomes; promoting ribosome inactivation. Belongs to the IFRD family. molecular_function biological_process uc009rmd.1 uc009rmd.2 uc009rmd.3 
ENSMUST00000010195.14 Hyal1 ENSMUST00000010195.14 hyaluronoglucosaminidase 1, transcript variant 1 (from RefSeq NM_008317.6) B1AV90 ENSMUST00000010195.1 ENSMUST00000010195.10 ENSMUST00000010195.11 ENSMUST00000010195.12 ENSMUST00000010195.13 ENSMUST00000010195.2 ENSMUST00000010195.3 ENSMUST00000010195.4 ENSMUST00000010195.5 ENSMUST00000010195.6 ENSMUST00000010195.7 ENSMUST00000010195.8 ENSMUST00000010195.9 HYAL1_MOUSE NM_008317 O70229 Q8CE62 Q8QZX3 Q8VBW7 Q8VDK0 Q91ZJ9 uc009rlv.1 uc009rlv.2 uc009rlv.3 May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D- glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35; pH dependence: Optimum pH is 3.5-4.0. ; Secreted Lysosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91ZJ9-1; Sequence=Displayed; Name=2; IsoId=Q91ZJ9-2; Sequence=VSP_015923; Highly expressed in liver, kidney, lung and skin. Detected in embryos of all developmental stages, with high level at the 7 day stage. Belongs to the glycosyl hydrolase 56 family. response to reactive oxygen species catalytic activity hyalurononglucosaminidase activity extracellular region extracellular space cytoplasm lysosome carbohydrate metabolic process inflammatory response transcription factor binding metabolic process response to virus positive regulation of epithelial cell migration hydrolase activity hydrolase activity, acting on glycosyl bonds hyaluronan metabolic process hyaluronan biosynthetic process hyaluronan catabolic process positive regulation of cell growth negative regulation of cell growth cytoplasmic vesicle hyaluranon cable cellular response to platelet-derived growth factor stimulus cellular response to fibroblast growth factor stimulus positive regulation of angiogenesis positive regulation of cell adhesion positive regulation of growth response to antibiotic viral entry into host cell hyaluronan synthase activity positive regulation of epithelial cell proliferation cartilage development embryonic skeletal joint morphogenesis cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to pH cellular response to UV-B positive regulation of G1/S transition of mitotic cell cycle positive regulation of hyaluranon cable assembly virus receptor activity uc009rlv.1 uc009rlv.2 uc009rlv.3 
ENSMUST00000010198.5 Tusc2 ENSMUST00000010198.5 tumor suppressor 2, mitochondrial calcium regulator (from RefSeq NM_019742.4) ENSMUST00000010198.1 ENSMUST00000010198.2 ENSMUST00000010198.3 ENSMUST00000010198.4 Fus1 Lgcc NM_019742 Pdap2 Q9WVF8 TUSC2_MOUSE uc009rls.1 uc009rls.2 uc009rls.3 Myristoylation is required for tumor suppressor activity. Belongs to the TUSC2 family. natural killer cell differentiation molecular_function mitochondrion phagocytosis inflammatory response interleukin-15 production negative regulation of interleukin-17 production positive regulation of interleukin-10 production cell maturation defense response to Gram-negative bacterium regulation of mitochondrial membrane potential response to defense-related host reactive oxygen species production neutrophil mediated killing of gram-negative bacterium chemokine (C-C motif) ligand 5 production regulation of reactive oxygen species metabolic process uc009rls.1 uc009rls.2 uc009rls.3 
ENSMUST00000010201.9 Nprl2 ENSMUST00000010201.9 NPR2 like, GATOR1 complex subunit (from RefSeq NM_018879.2) ENSMUST00000010201.1 ENSMUST00000010201.2 ENSMUST00000010201.3 ENSMUST00000010201.4 ENSMUST00000010201.5 ENSMUST00000010201.6 ENSMUST00000010201.7 ENSMUST00000010201.8 NM_018879 NPRL2_MOUSE Nprl2 Q9WUE4 uc009rln.1 uc009rln.2 uc009rln.3 uc009rln.4 Catalytic component of the GATOR1 complex, a multiprotein complex that functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:26166573, PubMed:29768191). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (By similarity). In the presence of abundant amino acids, the GATOR1 complex is ubiquitinated and inhibited by GATOR2 (By similarity). Within the GATOR1 complex, NPRL2 constitutes the catalytic subunit that mediates the GAP activity (By similarity). Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr- 9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. Within the GATOR complex, component of the GATOR1 subcomplex, made of DEPDC5, NPRL2 and NPRL3. GATOR1 mediates the strong interaction of the GATOR complex with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) heterodimers. GATOR1 interacts with GPR155/LYCHOS; interaction takes place in presence of cholesterol and prevents interaction between GATOR1 and KICSTOR. Interacts with PDPK1. Lysosome membrane Note=Localization to lysosomes is mediated by the KICSTOR complex and is amino acid-independent. The arginine finger is critical for the GTPase-activating mechanism. In the presence of abundant amino acids, ubiquitinated at Lys-158 and Lys-357 via 'Lys-6'-linked ubiquitination by the WDR24 component of the GATOR2 complex, thereby inhibiting the GATOR1 complex and promoting mTORC1 activation. Embryonic lethality due to defective fetal liver hematopoiesis (PubMed:26166573). Embryos also display reduced methionine levels (PubMed:26166573). Lysosomal acidification is impaired, leading to defective lysosomal processing of cobalamin and methionine synthase (PubMed:26166573). Conditional deletion in skeletal muscle causes constitutive activation of mTORC1 signaling: muscle fibers are significantly larger and show altered fiber-type composition, with more fast-twitch glycolytic and fewer slow-twitch oxidative fibers (PubMed:29768191). Mice with a conditional deletion in muscle also have altered running behavior and enhanced glucose tolerance (PubMed:29768191). Belongs to the NPR2 family. protein kinase activity GTPase activator activity lysosome lysosomal membrane protein phosphorylation cellular response to nitrogen starvation positive regulation of autophagy membrane negative regulation of TOR signaling negative regulation of kinase activity cellular response to amino acid starvation positive regulation of GTPase activity Iml1 complex regulation of autophagosome assembly uc009rln.1 uc009rln.2 uc009rln.3 uc009rln.4 
ENSMUST00000010205.9 Gnat1 ENSMUST00000010205.9 G protein subunit alpha transducin 1 (from RefSeq NM_008140.3) ENSMUST00000010205.1 ENSMUST00000010205.2 ENSMUST00000010205.3 ENSMUST00000010205.4 ENSMUST00000010205.5 ENSMUST00000010205.6 ENSMUST00000010205.7 ENSMUST00000010205.8 GNAT1_MOUSE Gnat-1 NM_008140 P20612 Q80X34 uc009rmr.1 uc009rmr.2 uc009rmr.3 Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (By similarity). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP- bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity). Heterotrimeric G proteins are composed of 3 subunits alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RHO. Interacts with RGS9 and PDE6G (By similarity). Interacts (when myristoylated) with UNC119; interaction is required for localization in sensory neurons (By similarity). Cell projection, cilium, photoreceptor outer segment Membrane ; Peripheral membrane protein Photoreceptor inner segment Note=Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark- adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light. In the retina, expressed in the rod photoreceptors. Belongs to the G-alpha family. G(i/o/t/z) subfamily. nucleotide binding detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor binding photoreceptor outer segment photoreceptor inner segment GTPase activity protein binding GTP binding cytoplasm heterotrimeric G-protein complex signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger visual perception phototransduction phototransduction, visible light cell proliferation response to light intensity membrane rhodopsin mediated signaling pathway apical plasma membrane guanyl nucleotide binding G-protein beta/gamma-subunit complex binding photoreceptor connecting cilium eye photoreceptor cell development cell projection neuronal cell body metal ion binding response to stimulus detection of light stimulus involved in visual perception sensory perception of umami taste positive regulation of cyclic-nucleotide phosphodiesterase activity retina development in camera-type eye cellular response to electrical stimulus uc009rmr.1 uc009rmr.2 uc009rmr.3 
ENSMUST00000010210.13 Cacna2d2 ENSMUST00000010210.13 calcium channel, voltage-dependent, alpha 2/delta subunit 2, transcript variant 5 (from RefSeq NM_001174050.1) B2RY16 CA2D2_MOUSE ENSMUST00000010210.1 ENSMUST00000010210.10 ENSMUST00000010210.11 ENSMUST00000010210.12 ENSMUST00000010210.2 ENSMUST00000010210.3 ENSMUST00000010210.4 ENSMUST00000010210.5 ENSMUST00000010210.6 ENSMUST00000010210.7 ENSMUST00000010210.8 ENSMUST00000010210.9 Kiaa0558 NM_001174050 Q3TPT9 Q3TSS6 Q6PHS9 Q6REE3 Q8C8R8 Q8CHE9 Q920H5 Q920H6 Q9EQG2 Q9R142 uc009rli.1 uc009rli.2 uc009rli.3 uc009rli.4 The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q- type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Dimer formed of alpha-2-2 and delta-2 chains; disulfide- linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (Probable). Membrane ; Single-pass type I membrane protein Note=Colocalizes with CACNA1A in lipid raft fractions. Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Alpha2delta-2a; IsoId=Q6PHS9-1; Sequence=Displayed; Name=2; IsoId=Q6PHS9-2; Sequence=VSP_028061, VSP_028062; Name=3; Synonyms=Alpha2delta-2c; IsoId=Q6PHS9-3; Sequence=VSP_028063; Name=4; Synonyms=Alpha2delta-2b; IsoId=Q6PHS9-4; Sequence=VSP_028061; Name=5; IsoId=Q6PHS9-5; Sequence=VSP_028061, VSP_028062, VSP_028063; Name=6; IsoId=Q6PHS9-6; Sequence=VSP_028062, VSP_028063; Predominantly expressed in brain in a restricted pattern. Also expressed at lower level in kidney and testis Not expressed in lung at any moment of development. In brain, it localizes to sections of P21 brain. Expressed at high level in the cerebellum, with moderate levels in medulla, pons, and striatum. Also expressed in cortex, hippocampus, habenula and nucleus reticularis thalami (nRT). Strongly expressed in cerebellar Purkinje cells. The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. N-glycosylated. May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role. According to PubMed:11306709, it is processed, at least in vitro, while according to PubMed:17052222, it is only poorly processed in vivo. Note=Defects in Cacna2d2 are the cause of ducky phenotype (du). Du mice have spike-wave seizures characteristic of absence epilepsy and ataxia, with accompanying decreased calcium channel current in cerebellar Purkinje cells. Mice exhibit growth retardation, reduced life span, ataxic gait with apoptosis of cerebellar granule cells followed by Purkinje cell depletion, enhanced susceptibility to seizures, and cardiac abnormalities. Binds gabapentin, an antiepileptic drug. Belongs to the calcium channel subunit alpha-2/delta family. Sequence=AAL01651.1; Type=Frameshift; Evidence=; voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity voltage-gated calcium channel complex ion transport calcium ion transport neuromuscular junction development regulation of heart contraction membrane integral component of membrane regulation of ion transmembrane transport regulation of multicellular organism growth positive regulation of organ growth metal ion binding muscle fiber development rhythmic synaptic transmission calcium ion transmembrane transport uc009rli.1 uc009rli.2 uc009rli.3 uc009rli.4 
ENSMUST00000010239.6 Slc3a2 ENSMUST00000010239.6 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2, transcript variant 2 (from RefSeq NM_008577.5) 4F2_MOUSE ENSMUST00000010239.1 ENSMUST00000010239.2 ENSMUST00000010239.3 ENSMUST00000010239.4 ENSMUST00000010239.5 G3UWA6 Mdu1 NM_008577 P10852 Q54AH5 Slc3a2 uc012bib.1 uc012bib.2 uc012bib.3 Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:9915839, PubMed:10574970, PubMed:11011012, PubMed:10734121). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids. Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (By similarity). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA. SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8. When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (By similarity). Disulfide-linked heterodimer with a non-glycosylated light chain (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 or SLC7A11) (PubMed:9915839, PubMed:10574970, PubMed:11011012, PubMed:10734121). Interacts with TLCD3A/CT120 and ICAM1. Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1. Interacts with LAPTM4B; recruits SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (By similarity). Apical cell membrane Cell membrane ; Single-pass type II membrane protein Cell junction Lysosome membrane Melanosome Basolateral cell membrane Note=Localized at the plasma membrane when associated with SLC7A5 or SLC7A8. Localized to the apical membrane of placental syncytiotrophoblastic cells. Recruited to lysosomes by LAPTM4B (By similarity). Located selectively at cell-cell adhesion sites (PubMed:9915839). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P10852-1; Sequence=Displayed; Name=2; IsoId=P10852-2; Sequence=VSP_054953; Detected on the surface of embryonic epithelial cells in the epidermis, thymus, kidney, intestine, brain choroid plexus, and in retina. Detected in adult and embryonic brain, spleen, kidney, intestine and liver, and in adult testis (at protein level) (PubMed:9915839). Observed in all adult tissues tested with strongest expression in kidney, small intestine, spleen, thymus and liver (PubMed:9915839). Moderate expression in brain, stomach, heart, testis, lung, skin, pancreas and skeletal muscle. In brain expressed on capillary endothelia in cerebral cortex. Strong expression in the liver of 14 dpc embryo and in brain, spleen, liver, kidney and intestine of an 18 dpc embryo. Expression induced by concanavalin-A stimulation. Induced during cell activation but is subsequently maintained at constant levels throughout the cell cycle in exponentially growing cells. Phosphorylation on Ser-300 or Ser-302 and on Ser-420 by ecto- protein kinases favors heterotypic cell-cell interactions. N-glycosylated; N-glycosylation is crucial for trafficking and stability of SLC3A2 to the plasma membrane. Embryonically lethal between 3.5 and 9.5 dpc. Belongs to the SLC3A transporter family. Sequence=BAE36291.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; double-stranded RNA binding catalytic activity protein binding nucleus lysosome lysosomal membrane cytosol plasma membrane carbohydrate metabolic process amino acid transport cell surface neutral amino acid transmembrane transporter activity neutral amino acid transport tryptophan transport membrane integral component of membrane apical plasma membrane cell junction melanosome response to exogenous dsRNA synapse L-leucine import into cell amino acid transport complex uc012bib.1 uc012bib.2 uc012bib.3 
ENSMUST00000010241.14 Nxf1 ENSMUST00000010241.14 nuclear RNA export factor 1, transcript variant 1 (from RefSeq NM_016813.2) ENSMUST00000010241.1 ENSMUST00000010241.10 ENSMUST00000010241.11 ENSMUST00000010241.12 ENSMUST00000010241.13 ENSMUST00000010241.2 ENSMUST00000010241.3 ENSMUST00000010241.4 ENSMUST00000010241.5 ENSMUST00000010241.6 ENSMUST00000010241.7 ENSMUST00000010241.8 ENSMUST00000010241.9 NM_016813 NXF1_MOUSE O88985 Q3TJA5 Q99JX7 Tap uc008gmr.1 uc008gmr.2 uc008gmr.3 Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1- NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A- containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A- containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Heterodimer (via NTF2 domain) with NXT1 (By similarity). The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export (By similarity). Forms a complex with RANBP2/NUP358, NXT1 and RANGAP1 (By similarity). Associates with the exon junction complex (EJC) (PubMed:12093754). Associates with the transcription/export (TREX) complex (By similarity). Found in a mRNA complex with UPF3A and UPF3B (By similarity). Found in a post-splicing complex with RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1 (By similarity). Interacts (via N-terminus) with DHX9 (via N-terminus); this interaction is direct and negatively regulates NXF1-mediated nuclear export of constitutive transport element (CTE)-containing cellular mRNAs (By similarity). Interacts with FYTTD1/UIF (By similarity). Interacts with EIF4A3 (By similarity). Interacts with NUP42 (By similarity). Interacts with ALYREF/THOC4 (PubMed:10786854). Interacts with CHTOP (By similarity). Interacts with FRG1 (via N-terminus) (By similarity). Interacts with LUZP4 (By similarity). Interacts with FMR1; the interaction occurs in a mRNA-dependent and polyribosomes-independent manner in the nucleus (By similarity). Interacts with CPSF6 (via N- terminus); this interaction is direct (By similarity). Interacts with RBM15 (By similarity). Interacts with RBM15B (By similarity). Interacts with MCM3AP; this interaction is not mediated by RNA (By similarity). Interacts with DDX3X (via C-terminus); this interaction may be partly involved in DDX3X nuclear export and in NXF1 localization to stress granules. Interacts with PABPC1/PABP1 (By similarity). Nucleus, nucleoplasm Nucleus speckle Cytoplasm Nucleus, nuclear pore complex Nucleus envelope Cytoplasm, Stress granule Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles. Nucleus; nuclear rim. Expressed ubiquitously. The minimal CTE binding domain consists of an RNP-type RNA binding domain (RBD) and leucine-rich repeats. The nucleoporin binding domain consists of a NTF2 domain (also called NTF2-like domain) and a TAP-C domain (also called UBA-like domain). It has 2 nucleoporin-FG-repeats binding sites (one in the NTF2 and the other in the TAP-C domain) which contribute to nucleoporin association and act synergistically to export cellular mRNAs. The NTF2 domain is functional only in the presence of NXT1 and is essential for the export of mRNA from the nucleus. It inhibits RNA binding activity through an intramolecular interaction with the N- terminal RNA binding domain (RBD); the inhibition is removed by an association with the TREX complex, specifically involving ALYREF/THOC4 and THOC5. The TAP-C domain mediates direct interactions with nucleoporin- FG-repeats and is necessary and sufficient for localization of NXF1 to the nuclear rim. The conserved loop 594-NWD-596 of the TAP-C domain has a critical role in the interaction with nucleoporins. The leucine-rich repeats are essential for the export of mRNA from the nucleus. The RNA-binding domain is a non-canonical RNP-type domain. Belongs to the NXF family. transcription export complex nucleic acid binding RNA binding mRNA binding protein binding nucleus nuclear pore nucleoplasm cytoplasm RNA export from nucleus mRNA export from nucleus nuclear speck poly(A)+ mRNA export from nucleus nuclear inclusion body mRNA transport uc008gmr.1 uc008gmr.2 uc008gmr.3 
ENSMUST00000010248.4 Tmem223 ENSMUST00000010248.4 transmembrane protein 223 (from RefSeq NM_025791.1) ENSMUST00000010248.1 ENSMUST00000010248.2 ENSMUST00000010248.3 NM_025791 Q9CQE2 TM223_MOUSE Tmem223 uc008gms.1 uc008gms.2 Mitochondrial ribosome-associated protein involved in the first steps of cytochrome c oxidase complex (complex IV) biogenesis. Stimulates the translation of MT-CO1 mRNA and is a constituent of early MT-CO1 assembly intermediates. Associates with the mitochondrial ribosome. Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the TMEM223 family. molecular_function mitochondrion nervous system development membrane integral component of membrane uc008gms.1 uc008gms.2 
ENSMUST00000010249.7 Tmem179b ENSMUST00000010249.7 transmembrane protein 179B, transcript variant 1 (from RefSeq NM_026325.3) ENSMUST00000010249.1 ENSMUST00000010249.2 ENSMUST00000010249.3 ENSMUST00000010249.4 ENSMUST00000010249.5 ENSMUST00000010249.6 NM_026325 Q9CY24 Q9D8L7 T179B_MOUSE uc008gmt.1 uc008gmt.2 uc008gmt.3 uc008gmt.4 Membrane ; Multi-pass membrane protein Belongs to the TMEM179 family. molecular_function nucleolus biological_process membrane integral component of membrane nuclear speck uc008gmt.1 uc008gmt.2 uc008gmt.3 uc008gmt.4 
ENSMUST00000010250.4 Slc22a6 ENSMUST00000010250.4 solute carrier family 22 (organic anion transporter), member 6 (from RefSeq NM_008766.3) ENSMUST00000010250.1 ENSMUST00000010250.2 ENSMUST00000010250.3 NM_008766 Nkt Oat1 Q61185 Q8VC69 S22A6_MOUSE Slc22a6 uc008gme.1 uc008gme.2 uc008gme.3 uc008gme.4 Secondary active transporter that functions as a Na(+)- independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate (PubMed:15944205). Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine (By similarity). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (By similarity). Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion (By similarity). Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) (PubMed:15944205). May transport glutamate. Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body (By similarity). Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA) and 3-carboxy-4- methyl-5-propyl-2- furanpropionate(CMPF) and urate (By similarity). Xenobiotics include the mycotoxin ochratoxin (OTA) (By similarity). May also contribute to the transport of organic compounds in testes across the blood-testis- barrier (By similarity). Reaction=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out); Xref=Rhea:RHEA:76071, ChEBI:CHEBI:28965, ChEBI:CHEBI:59560; Evidence=; Reaction=a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out) = a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in); Xref=Rhea:RHEA:76075, ChEBI:CHEBI:28965, ChEBI:CHEBI:43029; Evidence=; Reaction=a dicarboxylate(in) + L-sepiapterin(out) = a dicarboxylate(out) + L-sepiapterin(in); Xref=Rhea:RHEA:76079, ChEBI:CHEBI:28965, ChEBI:CHEBI:194527; Evidence=; Reaction=a dicarboxylate(in) + prostaglandin F2alpha(out) = a dicarboxylate(out) + prostaglandin F2alpha(in); Xref=Rhea:RHEA:76119, ChEBI:CHEBI:28965, ChEBI:CHEBI:57404; Evidence=; Reaction=a dicarboxylate(in) + prostaglandin E2(out) = a dicarboxylate(out) + prostaglandin E2(in); Xref=Rhea:RHEA:76123, ChEBI:CHEBI:28965, ChEBI:CHEBI:606564; Evidence=; Reaction=3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out); Xref=Rhea:RHEA:76127, ChEBI:CHEBI:28965, ChEBI:CHEBI:58165; Evidence=; Reaction=3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out); Xref=Rhea:RHEA:76131, ChEBI:CHEBI:28965, ChEBI:CHEBI:57746; Evidence=; Reaction=a dicarboxylate(in) + urate(out) = a dicarboxylate(out) + urate(in); Xref=Rhea:RHEA:76135, ChEBI:CHEBI:17775, ChEBI:CHEBI:28965; Evidence=; Reaction=glutarate(in) + kynurenate(out) = glutarate(out) + kynurenate(in); Xref=Rhea:RHEA:75999, ChEBI:CHEBI:30921, ChEBI:CHEBI:58454; Evidence=; Reaction=(indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3- yl)acetate(in) + a dicarboxylate(out); Xref=Rhea:RHEA:75983, ChEBI:CHEBI:28965, ChEBI:CHEBI:30854; Evidence=; Reaction=a dicarboxylate(in) + indoxyl sulfate(out) = a dicarboxylate(out) + indoxyl sulfate(in); Xref=Rhea:RHEA:75987, ChEBI:CHEBI:28965, ChEBI:CHEBI:144643; Evidence=; Reaction=a dicarboxylate(in) + N-benzoylglycine(out) = a dicarboxylate(out) + N-benzoylglycine(in); Xref=Rhea:RHEA:75991, ChEBI:CHEBI:28965, ChEBI:CHEBI:606565; Evidence=; Reaction=3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out); Xref=Rhea:RHEA:75995, ChEBI:CHEBI:28965, ChEBI:CHEBI:194524; Evidence=; Basolateral cell membrane ulti-pass membrane protein Basal cell membrane ; Multi-pass membrane protein Note=Localized to the basolateral side of proximal convoluted tubules corresponding to tubule segments S1 and S2. Expressed in kidney (PubMed:9045672, PubMed:9880528, PubMed:15944205). In kidney, restricted to the proximal convoluted tubule (representing S1 and S2 segments) (PubMed:9045672, PubMed:15944205). In brain, expressed in neurons of the cortex cerebri and hippocampus as well as in the ependymal cell layer of the choroid plexus (PubMed:9045672, PubMed:15944205). Developmentally regulated with significant expression beginning at 18 dpc and rising just before birth. Multiple cysteine residues are necessary for proper targeting to the plasma membrane. Glycosylated. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane. Involved in the renal transport of a variety of drugs with well-known nephrotoxic potential, therefore may play a role in the etiology of the drug-associated nephrotoxicity (By similarity). Uptakes the diagnostic agent PAH/para-aminohippurate and clinically used drugs (PubMed:9045672, PubMed:9880528, PubMed:10744714, PubMed:14979872, PubMed:14749323). Mediates the bidirectional transport of PAH/para- aminohippurate (By similarity). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. inorganic anion exchanger activity plasma membrane integral component of plasma membrane caveola anion transport organic anion transmembrane transporter activity anion:anion antiporter activity sodium-independent organic anion transmembrane transporter activity inorganic anion transport organic anion transport alpha-ketoglutarate transport membrane integral component of membrane basolateral plasma membrane transmembrane transporter activity chloride ion binding response to methotrexate macromolecular complex protein homodimerization activity sodium-independent organic anion transport protein homooligomerization transmembrane transport renal tubular secretion anion transmembrane transport uc008gme.1 uc008gme.2 uc008gme.3 uc008gme.4 
ENSMUST00000010267.10 Slc47a1 ENSMUST00000010267.10 solute carrier family 47, member 1 (from RefSeq NM_026183.5) ENSMUST00000010267.1 ENSMUST00000010267.2 ENSMUST00000010267.3 ENSMUST00000010267.4 ENSMUST00000010267.5 ENSMUST00000010267.6 ENSMUST00000010267.7 ENSMUST00000010267.8 ENSMUST00000010267.9 Mate1 NM_026183 Q5SS45 Q8K0H1 Q9CQ64 S47A1_MOUSE uc007jhi.1 uc007jhi.2 uc007jhi.3 uc007jhi.4 Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:16641166, PubMed:19332510). Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (By similarity). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (By similarity). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis- barrier (By similarity). Reaction=H(+)(in) + thiamine(out) = H(+)(out) + thiamine(in); Xref=Rhea:RHEA:71271, ChEBI:CHEBI:15378, ChEBI:CHEBI:18385; Evidence=; Reaction=estrone 3-sulfate(in) + H(+)(out) = estrone 3-sulfate(out) + H(+)(in); Xref=Rhea:RHEA:72139, ChEBI:CHEBI:15378, ChEBI:CHEBI:60050; Evidence=; Reaction=creatinine(in) + H(+)(out) = creatinine(out) + H(+)(in); Xref=Rhea:RHEA:72183, ChEBI:CHEBI:15378, ChEBI:CHEBI:16737; Evidence=; Reaction=agmatine(in) + H(+)(out) = agmatine(out) + H(+)(in); Xref=Rhea:RHEA:72127, ChEBI:CHEBI:15378, ChEBI:CHEBI:58145; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72128; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:72129; Evidence=; Kinetic parameters: KM=0.41 mM for TEA ; Vmax=0.6 nmol/min/mg enzyme toward TEA ; pH dependence: Optimum pH is 8.0-8.5. Active from pH 6 to 8.5. ; Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Note=Localizes to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K0H1-1; Sequence=Displayed; Name=2; IsoId=Q8K0H1-2; Sequence=VSP_029906, VSP_029907; Predominantly expressed in kidney and liver (PubMed:24961373). Also expressed in various cells, including brain glia-like cells and capillaries, pancreatic duct cells, urinary bladder epithelium, adrenal gland cortex, heart, stomach, small intestine, thyroid gland, testes, alpha cells of the islets of Langerhans, Leydig cells, and vitamin A-storing Ito cells. Expressed in heart, stomach, small intestine, bladder, thyroid gland, adrenal gland and testes (at protein level). Deficient mice are viable and fertile without any overt phenotypical or histological alterations. However, mice exhibit increased blood urea nitrogen, increased circulating creatinine, and abnormal metformin pharmacokinetics, including increased plasma and tissue metformin concentration with decreased kidney and liver metformin clearance. Mediates the efflux of cationic compounds such as the model cations, tetraethylammonium (TEA), the neurotoxin 1-methyl-4- phenylpyridinium (MPP), the platinum-based drugs cisplatin and oxaliplatin, the drugs procainamide, acyclovir and topotecan, or weak bases that are positively charged at physiological pH, such as cimetidine or the antidiabetic drug metformin. Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. Sequence=BC031436; Type=Frameshift; Evidence=; plasma membrane cation transport drug transmembrane transport antiporter activity organic cation transport drug transport membrane integral component of membrane vesicle amide transport amide transmembrane transporter activity xenobiotic transport xenobiotic transporter activity transmembrane transport uc007jhi.1 uc007jhi.2 uc007jhi.3 uc007jhi.4 
ENSMUST00000010278.12 Wdr77 ENSMUST00000010278.12 WD repeat domain 77 (from RefSeq NM_027432.3) ENSMUST00000010278.1 ENSMUST00000010278.10 ENSMUST00000010278.11 ENSMUST00000010278.2 ENSMUST00000010278.3 ENSMUST00000010278.4 ENSMUST00000010278.5 ENSMUST00000010278.6 ENSMUST00000010278.7 ENSMUST00000010278.8 ENSMUST00000010278.9 MEP50_MOUSE Mep50 NM_027432 Q3TFJ1 Q8BSH8 Q99J09 Q9CZY5 Wdr77 uc008qvp.1 uc008qvp.2 uc008qvp.3 Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (By similarity). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles (By similarity). Might play a role in transcription regulation (By similarity). The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain- containing proteins and subsequent localization to the meiotic nuage (PubMed:19584108). Substrate-recognition component of the DCX(WDR77) complex, which mediates ubiquitination and degradation of Irgm1 in intestinal cells. Component of the methylosome complex composed of PRMT5, WDR77 and CLNS1A (By similarity). Found in a complex composed of PRMT5, WDR77 and RIOK1 (By similarity). RIOK1 and CLNS1A bound directly to PRMT5 at the same binding site, in a mutually exclusive manner, which allows the recruitment of distinct methylation substrates, such as nucleolin/NCL and Sm proteins, respectively (By similarity). Found in a complex with the component of the methylosome, PRMT5, CLNS1A, WDR77, PRMT1 and ERH (By similarity). Directly interacts with PRMT5, as well as with several Sm proteins, including SNRPB and SNRPD2 and, more weakly, SNRPD3 and SNRPE (By similarity). Forms a compact hetero-octamer with PRMT5, decorating the outer surface of a PRMT5 tetramer (By similarity). Interacts with SUZ12 and histone H2A/H2AC20, but not with histones H2B, H3 nor H4 (PubMed:16712789). Interacts with CTDP1 and LSM11 (By similarity). Interacts with APEX1, AR and NKX3-1 (By similarity). Interacts with CHTOP (By similarity). Interacts with FAM47E (By similarity). Component of the DCX(WDR77) complex, composed of Cul4b, Ddb1, Wdr77 and Rbx1 (PubMed:35197566). Interacts with TSC22D2 (By similarity). Nucleus Cytoplasm protein binding nucleus nucleoplasm cytoplasm Golgi apparatus cytosol regulation of transcription from RNA polymerase II promoter positive regulation of cell proliferation negative regulation of cell proliferation methyl-CpG binding ligand-dependent nuclear receptor transcription coactivator activity methylosome secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development negative regulation of epithelial cell proliferation involved in prostate gland development positive regulation of nucleic acid-templated transcription uc008qvp.1 uc008qvp.2 uc008qvp.3 
ENSMUST00000010279.10 Tmigd3 ENSMUST00000010279.10 transmembrane and immunoglobulin domain containing 3, transcript variant 2 (from RefSeq NM_027025.4) ENSMUST00000010279.1 ENSMUST00000010279.2 ENSMUST00000010279.3 ENSMUST00000010279.4 ENSMUST00000010279.5 ENSMUST00000010279.6 ENSMUST00000010279.7 ENSMUST00000010279.8 ENSMUST00000010279.9 G3X8R9 NM_027025 Q9DAR9 TMIG3_MOUSE uc008qvh.1 uc008qvh.2 uc008qvh.3 uc008qvh.4 uc008qvh.5 This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 3' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:11542). [provided by RefSeq, Nov 2014]. Membrane ; Single- pass type I membrane protein membrane integral component of membrane uc008qvh.1 uc008qvh.2 uc008qvh.3 uc008qvh.4 uc008qvh.5 
ENSMUST00000010286.8 Tnfrsf13b ENSMUST00000010286.8 tumor necrosis factor receptor superfamily, member 13b, transcript variant 1 (from RefSeq NM_021349.3) ENSMUST00000010286.1 ENSMUST00000010286.2 ENSMUST00000010286.3 ENSMUST00000010286.4 ENSMUST00000010286.5 ENSMUST00000010286.6 ENSMUST00000010286.7 NM_021349 Q9DBZ3 Q9ET35 TR13B_MOUSE Taci uc007jha.1 uc007jha.2 uc007jha.3 Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin- dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity (By similarity). Binds TRAF2, TRAF5 and TRAF6. Binds the NH2-terminal domain of CAMLG with its C-terminus (By similarity). Membrane ; Single-pass type III membrane protein B cell homeostasis hematopoietic progenitor cell differentiation adaptive immune response immune system process integral component of plasma membrane external side of plasma membrane membrane integral component of membrane negative regulation of B cell proliferation uc007jha.1 uc007jha.2 uc007jha.3 
ENSMUST00000010298.7 Spire2 ENSMUST00000010298.7 spire type actin nucleation factor 2 (from RefSeq NM_172287.2) ENSMUST00000010298.1 ENSMUST00000010298.2 ENSMUST00000010298.3 ENSMUST00000010298.4 ENSMUST00000010298.5 ENSMUST00000010298.6 NM_172287 Q8K1S6 Q8R0R2 SPIR2_MOUSE spir-2 uc009nvj.1 uc009nvj.2 uc009nvj.3 Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703, PubMed:21983562). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:21983562). Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (By similarity). Cytoplasm, cytoskeleton Cytoplasm, cytosol Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K1S6-1; Sequence=Displayed; Name=2; IsoId=Q8K1S6-2; Sequence=VSP_031573; Detected in oocytes. Binds to actin monomers via the WH2 domain. The Spir-box targets binding to intracellular membrane structures. Belongs to the spire family. molecular_function actin binding cytoplasm cytosol cytoskeleton plasma membrane cell cortex protein transport membrane vesicle-mediated transport actin cytoskeleton organization cytoplasmic vesicle membrane cytoplasmic vesicle cleavage furrow formation polar body extrusion after meiotic divisions actin nucleation intracellular transport establishment of meiotic spindle localization formin-nucleated actin cable assembly positive regulation of double-strand break repair cleavage furrow uc009nvj.1 uc009nvj.2 uc009nvj.3 
ENSMUST00000010348.7 Fdx2 ENSMUST00000010348.7 ferredoxin 2, transcript variant 5 (from RefSeq NR_157204.1) ENSMUST00000010348.1 ENSMUST00000010348.2 ENSMUST00000010348.3 ENSMUST00000010348.4 ENSMUST00000010348.5 ENSMUST00000010348.6 FDX2_MOUSE Fdx1l Fdx2 NR_157204 Q6P8M0 Q9CPW2 Q9CV00 uc009okb.1 uc009okb.2 uc009okb.3 Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 1 [2Fe-2S] cluster. ; Component of the mitochondrial core iron-sulfur cluster (ISC) complex composed of NFS1, LYRM4, NDUFAB1, ISCU, FXN, and FDX2; this complex is an heterohexamer containing two copies of each monomer. Form an heterodimer complex with NFS1. Interacts (in both their reduced and oxidized states) with the cysteine desulfurase (NFS1:LYRM4) complex; this interaction stimulates cysteine desulfurase activity, and serves as a reductant for Fe-S cluster assembly. Mitochondrion Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CPW2-1; Sequence=Displayed; Name=2; IsoId=Q9CPW2-2; Sequence=VSP_032498; Belongs to the adrenodoxin/putidaredoxin family. Sequence=BAB26771.1; Type=Frameshift; Evidence=; mitochondrion mitochondrial matrix biological_process electron carrier activity electron transport chain metal ion binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding oxidation-reduction process uc009okb.1 uc009okb.2 uc009okb.3 
ENSMUST00000010421.7 Bltp2 ENSMUST00000010421.7 bridge-like lipid transfer protein family member 2 (from RefSeq NM_001002004.2) BLTP2_MOUSE ENSMUST00000010421.1 ENSMUST00000010421.2 ENSMUST00000010421.3 ENSMUST00000010421.4 ENSMUST00000010421.5 ENSMUST00000010421.6 Kiaa0100 NM_001002004 Q3UE65 Q5SYL3 Q66JY1 Q6DIC4 Q80U77 Q8C1W6 Q8CE06 Q8CGE3 Q9CSS8 uc007kir.1 uc007kir.2 uc007kir.3 uc007kir.4 Tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution. Cell membrane Endoplasmic reticulum membrane Mitochondrion membrane Note=Localizes to endoplasmic reticulum-cell membrane and some endoplasmic reticulum- mitochondria contact sites. Belongs to the SABRE family. Sequence=AAH80706.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAB28000.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component extracellular region biological_process uc007kir.1 uc007kir.2 uc007kir.3 uc007kir.4 
ENSMUST00000010434.8 AI597479 ENSMUST00000010434.8 expressed sequence AI597479 (from RefSeq NM_133818.1) ASHWN_MOUSE ENSMUST00000010434.1 ENSMUST00000010434.2 ENSMUST00000010434.3 ENSMUST00000010434.4 ENSMUST00000010434.5 ENSMUST00000010434.6 ENSMUST00000010434.7 NM_133818 Q922M7 uc007avj.1 uc007avj.2 uc007avj.3 Component of the tRNA-splicing ligase complex. Nucleus Belongs to the ashwin family. molecular_function biological_process embryonic morphogenesis tRNA-splicing ligase complex uc007avj.1 uc007avj.2 uc007avj.3 
ENSMUST00000010451.8 Tmem86a ENSMUST00000010451.8 transmembrane protein 86A (from RefSeq NM_026436.3) ENSMUST00000010451.1 ENSMUST00000010451.2 ENSMUST00000010451.3 ENSMUST00000010451.4 ENSMUST00000010451.5 ENSMUST00000010451.6 ENSMUST00000010451.7 NM_026436 Q8C6I3 Q9D8N3 TM86A_MOUSE uc009gzy.1 uc009gzy.2 uc009gzy.3 Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen (PubMed:35835749, PubMed:36592658). Plays an important role in lysoplasmalogen metabolism in the adipocyte tissue and macrophages (PubMed:35835749, PubMed:36592658). Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3- saturated aldehyde + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:22544, ChEBI:CHEBI:15377, ChEBI:CHEBI:16870, ChEBI:CHEBI:73359, ChEBI:CHEBI:77287; EC=3.3.2.2; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:16905, ChEBI:CHEBI:15377, ChEBI:CHEBI:73359, ChEBI:CHEBI:77288, ChEBI:CHEBI:143890; EC=3.3.2.2; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Highly expressed in the jejunum, white adipose tissue, kidney and macrophages. Sterol-inducible in the macrophages and the induction is mediated by the liver X receptor (LXR) (PubMed:36592658). Up-regulated by high-fat diet in the white adipose tissue (PubMed:35835749). Adipocyte-specific knockout mice show elevated levels of lysoplasmalogens in adipose tissue and enhanced PKA-signaling pathway and mitochondrial oxidative metabolism in adipose tissue. Belongs to the TMEM86 family. membrane integral component of membrane alkenylglycerophosphocholine hydrolase activity alkenylglycerophosphoethanolamine hydrolase activity uc009gzy.1 uc009gzy.2 uc009gzy.3 
ENSMUST00000010502.13 Ifi35 ENSMUST00000010502.13 interferon-induced protein 35 (from RefSeq NM_027320.4) ENSMUST00000010502.1 ENSMUST00000010502.10 ENSMUST00000010502.11 ENSMUST00000010502.12 ENSMUST00000010502.2 ENSMUST00000010502.3 ENSMUST00000010502.4 ENSMUST00000010502.5 ENSMUST00000010502.6 ENSMUST00000010502.7 ENSMUST00000010502.8 ENSMUST00000010502.9 IN35_MOUSE Ifi35 Ifp35 NM_027320 Q3V2E7 Q9D8C4 uc007lox.1 uc007lox.2 uc007lox.3 Acts as a signaling pathway regulator involved in innate immune system response (PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with transcriptional regulator NMI to regulate immune response; the complex formation prevents proteasome- mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (By similarity). In complex with NMI, inhibits virus- triggered type I interferon/IFN-beta production (By similarity). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re- endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (By similarity). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (By similarity). Homodimer. Also interacts with B-ATF. Interacts with TRIM21. Interacts (via NID domains) with NMI (via NID domains); the interaction is direct and is facilitated by TRIM21. Cytoplasm Nucleus Secreted Note=Cytoplasmic IFI35 localizes in punctate granular structures (By similarity). Nuclear localization increased following IFN-alpha treatment (By similarity). Extracelullar following secretion by macrophage (By similarity). The NID domain 1 is involved in the negative regulation of p65/RELA transcription and the negative regulation of NF-kappa-B pathway activation. Phosphorylated. Dephosphorylation correlates with the formation of a complex with NMI. Knockout mice show decreased inflammatory response when exposed to infection or injury, which can lead to lower inflammation-induced mortality. Belongs to the NMI family. molecular_function nucleus biological_process uc007lox.1 uc007lox.2 uc007lox.3 
ENSMUST00000010506.10 Rdm1 ENSMUST00000010506.10 RAD52 motif 1, transcript variant 2 (from RefSeq NR_184640.1) ENSMUST00000010506.1 ENSMUST00000010506.2 ENSMUST00000010506.3 ENSMUST00000010506.4 ENSMUST00000010506.5 ENSMUST00000010506.6 ENSMUST00000010506.7 ENSMUST00000010506.8 ENSMUST00000010506.9 NR_184640 Q9CQK3 RDM1_MOUSE uc007lpp.1 uc007lpp.2 uc007lpp.3 May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA (By similarity). Homodimer. Nucleus. Cytoplasm. Nucleus, nucleolus. Nucleus, Cajal body. Nucleus, PML body. Note=After treatment with proteasomal inhibitors and mild heat-shock stress is relocalized to the nucleolus as dot-like or irregular subnuclear structures. Colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress. Relocalized in nucleolar caps during transcriptional arrest (By similarity). C-terminal half contains cytoplasmic retention domains as well as determinants involved in its stress-induced nucleolar accumulation. molecular_function nucleic acid binding DNA binding RNA binding nucleus nucleolus cytoplasm cytosol biological_process Cajal body PML body uc007lpp.1 uc007lpp.2 uc007lpp.3 
ENSMUST00000010520.10 Nedd8 ENSMUST00000010520.10 neural precursor cell expressed, developmentally down-regulated gene 8 (from RefSeq NM_008683.4) ENSMUST00000010520.1 ENSMUST00000010520.2 ENSMUST00000010520.3 ENSMUST00000010520.4 ENSMUST00000010520.5 ENSMUST00000010520.6 ENSMUST00000010520.7 ENSMUST00000010520.8 ENSMUST00000010520.9 NM_008683 Nedd8 Q3UI46 Q3UI46_MOUSE uc007uac.1 uc007uac.2 uc007uac.3 Nucleus Belongs to the ubiquitin family. nucleus nucleoplasm cytosol response to organic cyclic compound ubiquitin protein ligase binding protein neddylation uc007uac.1 uc007uac.2 uc007uac.3 
ENSMUST00000010536.9 Gosr1 ENSMUST00000010536.9 golgi SNAP receptor complex member 1, transcript variant 1 (from RefSeq NM_016810.4) ENSMUST00000010536.1 ENSMUST00000010536.2 ENSMUST00000010536.3 ENSMUST00000010536.4 ENSMUST00000010536.5 ENSMUST00000010536.6 ENSMUST00000010536.7 ENSMUST00000010536.8 GOSR1_MOUSE Gs28 NM_016810 O88630 Q91VU9 uc007kfz.1 uc007kfz.2 uc007kfz.3 Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi (By similarity). Component of several multiprotein Golgi SNARE complexes. Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2, SEC22B and BET1, and in complex with STX5 and COG3. Interacts with GABARAPL2 (By similarity). Golgi apparatus membrane ; Single-pass type IV membrane protein Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network. Enriched on vesicular components at the terminal rims of the Golgi. Decreased levels in 25-hydroxycholesterol treated melanocytes (at protein level). Belongs to the GOSR1 family. Golgi membrane SNAP receptor activity Golgi apparatus Golgi medial cisterna cis-Golgi network cytosol ER to Golgi vesicle-mediated transport vesicle fusion protein transport membrane integral component of membrane vesicle-mediated transport SNARE complex retrograde transport, endosome to Golgi regulation of vesicle targeting, to, from or within Golgi uc007kfz.1 uc007kfz.2 uc007kfz.3 
ENSMUST00000010550.12 Mrpl52 ENSMUST00000010550.12 mitochondrial ribosomal protein L52 (from RefSeq NM_026851.2) ENSMUST00000010550.1 ENSMUST00000010550.10 ENSMUST00000010550.11 ENSMUST00000010550.2 ENSMUST00000010550.3 ENSMUST00000010550.4 ENSMUST00000010550.5 ENSMUST00000010550.6 ENSMUST00000010550.7 ENSMUST00000010550.8 ENSMUST00000010550.9 NM_026851 Q6PAU6 Q9D0Y8 RM52_MOUSE uc007tvz.1 uc007tvz.2 uc007tvz.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D0Y8-1; Sequence=Displayed; Name=2; IsoId=Q9D0Y8-2; Sequence=VSP_022476; Belongs to the mitochondrion-specific ribosomal protein mL52 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation mitochondrial translation uc007tvz.1 uc007tvz.2 uc007tvz.3 
ENSMUST00000010579.8 Spaca7 ENSMUST00000010579.8 sperm acrosome associated 7, transcript variant 1 (from RefSeq NM_024279.4) ENSMUST00000010579.1 ENSMUST00000010579.2 ENSMUST00000010579.3 ENSMUST00000010579.4 ENSMUST00000010579.5 ENSMUST00000010579.6 ENSMUST00000010579.7 NM_024279 Q9D2S4 SPAC7_MOUSE Spaca7 uc009kwc.1 uc009kwc.2 uc009kwc.3 Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion. Secreted Cytoplasmic vesicle, secretory vesicle, acrosome lumen Note=Localized in perinuclear pro-acrosomal granules in round spermatides (PubMed:24307706). Localized between the inner and outer acrosomal membranes (matrix or lumen) in spermatozoa (PubMed:24307706). Secreted during acrosome exocytosis (PubMed:24307706). Testis-specific (PubMed:22495889, PubMed:24307706). Expressed in zygotene and pachytene spermatocytes, round spermatids, elongating spermatids and spermatozoa (at protein level) (PubMed:22495889, PubMed:24307706). Testis-specific (PubMed:22495889). acrosomal vesicle extracellular region negative regulation of cell adhesion single fertilization cytoplasmic vesicle acrosomal lumen uc009kwc.1 uc009kwc.2 uc009kwc.3 
ENSMUST00000010673.7 Gm266 ENSMUST00000010673.7 predicted gene 266 (from RefSeq NM_001033248.3) A6H634 A6H634_MOUSE ENSMUST00000010673.1 ENSMUST00000010673.2 ENSMUST00000010673.3 ENSMUST00000010673.4 ENSMUST00000010673.5 ENSMUST00000010673.6 Gm266 NM_001033248 uc007pdc.1 uc007pdc.2 uc007pdc.3 nucleotide binding GTPase activity GTP binding plasma membrane signal transduction membrane GDP binding negative regulation of cell migration Rap protein signal transduction uc007pdc.1 uc007pdc.2 uc007pdc.3 
ENSMUST00000010736.9 Dazl ENSMUST00000010736.9 deleted in azoospermia-like, transcript variant 1 (from RefSeq NM_010021.6) DAZL_MOUSE Dazl1 Dazla ENSMUST00000010736.1 ENSMUST00000010736.2 ENSMUST00000010736.3 ENSMUST00000010736.4 ENSMUST00000010736.5 ENSMUST00000010736.6 ENSMUST00000010736.7 ENSMUST00000010736.8 NM_010021 Q64368 uc008cyv.1 uc008cyv.2 uc008cyv.3 uc008cyv.4 uc008cyv.5 This gene encodes a member of the depleted in azoospermia-like (DAZL) protein family. Members of this family contain an RNA recognition motif, interact with poly A binding proteins, and may be involved in the initiation of translation. The encoded protein is expressed in the cytoplasm of pluripotent stem cells, and in both male and female germ cells, where it is essential for gametogenesis. Disruption of this gene is associated with infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]. RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts. Homodimer and heterodimer. Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2 (By similarity). Multiple DAZL RRMs can bind to a single RNA containing multiple GUU triplets. Q64368; Q64368: Dazl; NbExp=2; IntAct=EBI-2024439, EBI-2024439; Q64368; O88485: Dync1i1; NbExp=4; IntAct=EBI-2024439, EBI-492834; Q64368; P63168: Dynll1; NbExp=12; IntAct=EBI-2024439, EBI-349121; Cytoplasm Expressed predominantly in testis with lower levels in ovary. In testis, it is expressed in pachytene spermatocytes and at lower level in type-B spermatogonia, preleptotene and zygotene spermatocytes. In ovary, it is expressed in maturing follicles. In embryonic and prepuberal ovary, it is expressed in the oocyte and follicular cells. In the testis, expression increases steadily after birth until the first spermatogonial cells appear, levels off as the first spermatogenic cells enter meiosis (10 days after birth) and remains at this level thereafter. The DAZ domain mediates the interaction with DAZAP1 and DAZAP2. Belongs to the RRM DAZ family. oocyte maturation nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding nucleus cytoplasm polysome regulation of translation female meiosis II multicellular organism development germ cell development spermatogenesis translation activator activity cell differentiation macromolecular complex identical protein binding positive regulation of meiotic nuclear division positive regulation of translational initiation oogenesis 3'-UTR-mediated mRNA stabilization uc008cyv.1 uc008cyv.2 uc008cyv.3 uc008cyv.4 uc008cyv.5 
ENSMUST00000010795.5 Acaa1b ENSMUST00000010795.5 acetyl-Coenzyme A acyltransferase 1B, transcript variant 1 (from RefSeq NM_146230.4) Acaa1 Acaa1b ENSMUST00000010795.1 ENSMUST00000010795.2 ENSMUST00000010795.3 ENSMUST00000010795.4 NM_146230 Q8VCH0 THIKB_MOUSE uc009saj.1 uc009saj.2 uc009saj.3 Responsible for the thiolytic cleavage of straight chain 3- keto fatty acyl-CoAs (3-oxoacyl-CoAs) (Probable). Plays an important role in fatty acid peroxisomal beta-oxidation (Probable). Catalyzes the cleavage of short, medium, long, and very long straight chain 3- oxoacyl-CoAs (By similarity). Reaction=acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA; Xref=Rhea:RHEA:21564, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58342, ChEBI:CHEBI:90726; EC=2.3.1.16; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21566; Evidence=; Reaction=2 acetyl-CoA = acetoacetyl-CoA + CoA; Xref=Rhea:RHEA:21036, ChEBI:CHEBI:57286, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.9; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21038; Evidence=; Reaction=acetyl-CoA + hexanoyl-CoA = 3-oxooctanoyl-CoA + CoA; Xref=Rhea:RHEA:31203, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:62619, ChEBI:CHEBI:62620; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31205; Evidence=; Reaction=acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA; Xref=Rhea:RHEA:18161, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57349, ChEBI:CHEBI:57385; EC=2.3.1.155; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18163; Evidence=; Reaction=3-oxohexadecanedioyl-CoA + CoA = acetyl-CoA + tetradecanedioyl-CoA; Xref=Rhea:RHEA:40343, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:77081, ChEBI:CHEBI:77084; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40344; Evidence=; Reaction=3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA; Xref=Rhea:RHEA:39131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74298, ChEBI:CHEBI:74304; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39132; Evidence=; Lipid metabolism; peroxisomal fatty acid beta-oxidation. Homodimer. Interacts (via PTS2-type peroxisomal targeting signal region) with PEX7; leading to its translocation into peroxisomes. Peroxisome Note=Transported into peroxisomes following association with PEX7. Mainly expressed in liver; weaker levels in kidney, intestine and white adipose tissue. The PTS2-type peroxisomal targeting signal, which mediates interaction with PEX7 and localization to peroxisomes, is cleaved following import into peroxisomes. Belongs to the thiolase-like superfamily. Thiolase family. catalytic activity acetyl-CoA C-acetyltransferase activity acetyl-CoA C-acyltransferase activity mitochondrion peroxisome lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation phenylacetate catabolic process transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups acetyl-CoA C-myristoyltransferase activity uc009saj.1 uc009saj.2 uc009saj.3 
ENSMUST00000010807.6 Fads1 ENSMUST00000010807.6 fatty acid desaturase 1 (from RefSeq NM_146094.2) ENSMUST00000010807.1 ENSMUST00000010807.2 ENSMUST00000010807.3 ENSMUST00000010807.4 ENSMUST00000010807.5 FADS1_MOUSE Fads1 NM_146094 Q3U494 Q8BZX7 Q8R0G8 Q8VC07 Q920L1 uc008gpe.1 uc008gpe.2 uc008gpe.3 uc008gpe.4 uc008gpe.5 uc008gpe.6 Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n- 6) and eicosapentaenoate (EPA) (20:5n-3), respectively (Probable). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (PubMed:22534642). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity). Reaction=(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)- [cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:46424, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57368, ChEBI:CHEBI:74264; EC=1.14.19.44; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46425; Evidence=; Reaction=(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:46420, Rhea:RHEA- COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:73862, ChEBI:CHEBI:74265; EC=1.14.19.44; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46421; Evidence=; Reaction=(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:46060, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:74296, ChEBI:CHEBI:85651; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46061; Evidence=; Lipid metabolism; polyunsaturated fatty acid biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Mitochondrion Highly expressed in the adrenal gland, liver, brain, and testis, tissues where lipogenesis and steroidogenesis are active (PubMed:11792729). Expressed in colonic mucosa (PubMed:22534642). Expression in liver is down-regulated by dietary PUFA. The histidine box domains may contain the active site and/or be involved in metal ion binding. Knockout mice die prematurely with no survivors past 12 weeks of age. This phenotype can be rescued by adding arachidonic acid (AA) to the diet. Belongs to the fatty acid desaturase type 1 family. nucleus mitochondrion endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process aging response to nutrient cellular response to starvation response to sucrose response to organic substance response to organic cyclic compound membrane integral component of membrane linoleoyl-CoA desaturase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water arachidonic acid metabolic process response to insulin response to vitamin A response to isolation stress long-chain fatty acid biosynthetic process intracellular membrane-bounded organelle oxidation-reduction process uc008gpe.1 uc008gpe.2 uc008gpe.3 uc008gpe.4 uc008gpe.5 uc008gpe.6 
ENSMUST00000010899.14 Cars1 ENSMUST00000010899.14 cysteinyl-tRNA synthetase 1, transcript variant 1 (from RefSeq NM_013742.5) Cars ENSMUST00000010899.1 ENSMUST00000010899.10 ENSMUST00000010899.11 ENSMUST00000010899.12 ENSMUST00000010899.13 ENSMUST00000010899.2 ENSMUST00000010899.3 ENSMUST00000010899.4 ENSMUST00000010899.5 ENSMUST00000010899.6 ENSMUST00000010899.7 ENSMUST00000010899.8 ENSMUST00000010899.9 NM_013742 O88303 Q8BP81 Q8CAY7 Q8CCE3 Q8K0S4 Q9ER68 Q9ER72 SYCC_MOUSE uc009kpn.1 uc009kpn.2 uc009kpn.3 Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys). Reaction=ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L- cysteinyl-tRNA(Cys); Xref=Rhea:RHEA:17773, Rhea:RHEA-COMP:9661, Rhea:RHEA-COMP:9679, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:35235, ChEBI:CHEBI:78442, ChEBI:CHEBI:78517, ChEBI:CHEBI:456215; EC=6.1.1.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17774; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Homodimer. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ER72-1; Sequence=Displayed; Name=2; IsoId=Q9ER72-2; Sequence=VSP_010258; Belongs to the class-I aminoacyl-tRNA synthetase family. tRNA binding nucleotide binding aminoacyl-tRNA ligase activity cysteine-tRNA ligase activity ATP binding cytoplasm cytosol translation tRNA aminoacylation for protein translation cysteinyl-tRNA aminoacylation ligase activity protein homodimerization activity metal ion binding uc009kpn.1 uc009kpn.2 uc009kpn.3 
ENSMUST00000010904.5 Phlda2 ENSMUST00000010904.5 pleckstrin homology like domain, family A, member 2 (from RefSeq NM_009434.2) ENSMUST00000010904.1 ENSMUST00000010904.2 ENSMUST00000010904.3 ENSMUST00000010904.4 Ipl NM_009434 O08969 PHLA2_MOUSE Tssc3 uc009kpj.1 uc009kpj.2 uc009kpj.3 This gene is one of several genes in the imprinted gene domain on chromosome 7. Studies using knockout mice have shown that the product of this gene regulates placental growth. Transcripts from this gene are most abundant in placenta and yolk sac, and are almost entirely transcribed from the maternal allele. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF615806.1, AK131929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 15327781 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids. Cytoplasm Membrane ; Peripheral membrane protein Specifically expressed at high levels in extraembryonic tissues in the developing conceptus (at protein level). Expressed in placenta and yolc sac. Expressed at low levels in fetal liver and kidney. Expressed at high levels in the very early conceptus limited to polar trophectoderm. Strongly expressed in the ectoplacental cone shortly after implantation at 5.5 dpc, and the high expression remains restricted to the extraembryonic tissues at later stages. By 10.5 dpc expression is restricted to the labyrinthine trophoblast and the endodermal component of the visceral yolk sac. Between 12.5 and 14.4 dpc expression in placenta decreases, due to a number of expressing cells. On day 12 of gestation, the abundant expressing cells are trophoblast at the chorionic plate, and clustered type II trophoblast deeper in the labyrinth. Less expressed by terminally differentiated trophoblast. As early as 14.5 dpc, becomes confined to a monolayer of cells at the chorionic plate and to rare cells in septa that protrude into the labyrinth (at protein level). Maternal Phlda2 allele is activated, while paternal Phlda2 is repressed due to genomic imprinting. The PH domain binds phosphoinositides with a broad specificity. It may compete with the PH domain of some other proteins, thereby interfering with their binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). Mice are viable, and show overgrowth of placentas with expansion of the spongiotrophoblast. These larger placentas do not confer a fetal growth advantage. The Phlda2 locus is imprinted. Loss of imprinting results in overexpression, leading to placental growth retardation phenotypes. Belongs to the PHLDA2 family. placenta development cytoplasm animal organ morphogenesis regulation of gene expression membrane regulation of cell migration regulation of embryonic development regulation of spongiotrophoblast cell proliferation regulation of glycogen metabolic process regulation of growth hormone activity uc009kpj.1 uc009kpj.2 uc009kpj.3 
ENSMUST00000010940.11 Asz1 ENSMUST00000010940.11 ankyrin repeat, SAM and basic leucine zipper domain containing 1 (from RefSeq NM_023729.3) ASZ1_MOUSE Asz1 ENSMUST00000010940.1 ENSMUST00000010940.10 ENSMUST00000010940.2 ENSMUST00000010940.3 ENSMUST00000010940.4 ENSMUST00000010940.5 ENSMUST00000010940.6 ENSMUST00000010940.7 ENSMUST00000010940.8 ENSMUST00000010940.9 G3X8S0 Gasz NM_023729 Q6PD92 Q8VD46 Q9JKQ7 uc009bah.1 uc009bah.2 uc009bah.3 uc009bah.4 Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. Interacts with DDX4, PIWIL1, RANBP9 and TDRD1. Cytoplasm te=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to pi- bodies, a subset of the nuage which contains primary piRNAs. Expressed exclusively in testis and ovary with higher levels in testis. Expressed in pachytene spermatocytes and early spermatids in the developing and adult testes and in oocytes in all stages of oogenesis in the ovary. Also expressed in preimplantive embryos. Mice are viable but show profound defect in male meiosis leading to male sterility. Testes display increased hypomethylation of retrotransposons and their subsequent expression as well as piRNAs suppression. Sequence=AAF30297.1; Type=Erroneous gene model prediction; Evidence=; protein binding cytoplasm cytosol male meiosis multicellular organism development germ cell development spermatogenesis cell differentiation gene silencing by RNA piRNA metabolic process DNA methylation involved in gamete generation meiotic cell cycle pi-body uc009bah.1 uc009bah.2 uc009bah.3 uc009bah.4 
ENSMUST00000010941.6 Wnt2 ENSMUST00000010941.6 wingless-type MMTV integration site family, member 2 (from RefSeq NM_023653.5) ENSMUST00000010941.1 ENSMUST00000010941.2 ENSMUST00000010941.3 ENSMUST00000010941.4 ENSMUST00000010941.5 Irp NM_023653 P21552 Q9CZW3 WNT2_MOUSE Wnt-2 uc009bag.1 uc009bag.2 uc009bag.3 uc009bag.4 Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:19686689). Functions as a upstream regulator of FGF10 expression (PubMed:19686689). Plays an important role in embryonic lung development (PubMed:19686689). May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (PubMed:20018874). Secreted, extracellular space, extracellular matrix Secreted In embryos in the developing allantois, pericardium heart, and ventral-lateral mesoderm; in adults in lung, brain, heart and placenta. Detected in ventral mesencephalon from 10.5 to 15.5 dpc; expression levels decrease moderately, but steadily during this period (PubMed:20018874). Detected in the lateral plate mesoderm surrounding the ventral aspect of the anterior foregut from 9.0 to 10.5 dpc (PubMed:19686689). Detected in the developing mesenchyme with higher levels surrounding the distal regions of the branching airways from 12.5 to 18.5 dpc (PubMed:19686689). Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. Nearly complete perinatal lethality within minutes after birth, due to lung hypoplasia (PubMed:19686689). About 4% survive for more than 30 days (PubMed:19686689). Combined disruption of Wnt2 and Wnt2b leads to lung agenesis and loss of trachea development (PubMed:19686689). In contrast, development of liver, stomach, intestine, pancreas and kidneys appears grossly normal (PubMed:19686689). Belongs to the Wnt family. positive regulation of endothelial cell proliferation positive regulation of mesenchymal cell proliferation receptor binding frizzled binding cytokine activity extracellular region extracellular space cytoplasm cell-cell signaling multicellular organism development positive regulation of cell proliferation Wnt signaling pathway neuron differentiation lung development extrinsic component of external side of plasma membrane cell proliferation in midbrain cell fate commitment positive regulation of transcription from RNA polymerase II promoter receptor agonist activity positive regulation of fibroblast proliferation positive regulation of sequence-specific DNA binding transcription factor activity atrial cardiac muscle tissue morphogenesis positive regulation of cardiac muscle cell proliferation canonical Wnt signaling pathway cardiac epithelial to mesenchymal transition lung induction positive regulation of epithelial cell proliferation involved in lung morphogenesis labyrinthine layer blood vessel development mammary gland epithelium development cellular response to transforming growth factor beta stimulus midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation uc009bag.1 uc009bag.2 uc009bag.3 uc009bag.4 
ENSMUST00000010974.9 Kdelr3 ENSMUST00000010974.9 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 (from RefSeq NM_134090.2) ENSMUST00000010974.1 ENSMUST00000010974.2 ENSMUST00000010974.3 ENSMUST00000010974.4 ENSMUST00000010974.5 ENSMUST00000010974.6 ENSMUST00000010974.7 ENSMUST00000010974.8 ERD23_MOUSE NM_134090 Q3UVS1 Q8R1L4 Q91X67 uc007wto.1 uc007wto.2 uc007wto.3 uc007wto.4 Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasmic vesicle, COPI-coated vesicle membrane ; Multi-pass membrane protein Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity). Belongs to the ERD2 family. Golgi membrane KDEL sequence binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cis-Golgi network protein retention in ER lumen ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER protein transport membrane integral component of membrane vesicle-mediated transport COPI-coated vesicle membrane cytoplasmic vesicle ER retention sequence binding uc007wto.1 uc007wto.2 uc007wto.3 uc007wto.4 
ENSMUST00000010985.8 Cfap97d1 ENSMUST00000010985.8 CFAP97 domain containing 1 (from RefSeq NM_029287.1) CF97D_MOUSE ENSMUST00000010985.1 ENSMUST00000010985.2 ENSMUST00000010985.3 ENSMUST00000010985.4 ENSMUST00000010985.5 ENSMUST00000010985.6 ENSMUST00000010985.7 NM_029287 Q9DAN9 uc007lqb.1 uc007lqb.2 uc007lqb.3 Required for male fertility through its role in axonemal doublet stabilization which is essential for sperm motility and fertilization. Expressed exclusively in testis. Expression starts at postnatal day 20 and continues throughout adulthood. Male subfertility. Sperm show an impaired ability to penetrate the zona pellucida and abnormal motility characterized by frequent stalling in the anti-hook position with the flagellum and hook of the sperm head pointing in opposite directions. Sperm flagella lack outer microtubule doublet 4 in 63% of mutants while doublet 7 is missing in 14.8% of mutants. A small number of mutants have multiple doublets missing but these are relatively rare: the 4th and 7th doublets are missing in 1.6% of mutants; the 4th, 5th and 7th doublets are missing in 3.7%; the 4th, 5th and 6th doublets are missing in 1.23%; and the 4th, 5th, 6th and 7th doublets are missing in 1.23%. Belongs to the CFAP97 family. molecular_function cellular_component biological_process uc007lqb.1 uc007lqb.2 uc007lqb.3 
ENSMUST00000011055.7 Apip ENSMUST00000011055.7 APAF1 interacting protein, transcript variant 1 (from RefSeq NM_019735.4) Apip ENSMUST00000011055.1 ENSMUST00000011055.2 ENSMUST00000011055.3 ENSMUST00000011055.4 ENSMUST00000011055.5 ENSMUST00000011055.6 MTNB_MOUSE Mmrp19 NM_019735 Q8BP46 Q9WVQ5 uc008lin.1 uc008lin.2 uc008lin.3 uc008lin.4 Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. Reaction=S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3- dioxopentyl phosphate + H2O; Xref=Rhea:RHEA:15549, ChEBI:CHEBI:15377, ChEBI:CHEBI:58548, ChEBI:CHEBI:58828; EC=4.2.1.109; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. Homotetramer. Interacts with APAF1. May interact with CASP1. Cytoplasm Expressed in skeletal muscle (at protein level). Up-regulated upon ischemia/hypoxia. Belongs to the aldolase class II family. MtnB subfamily. cytoplasm apoptotic process zinc ion binding cellular amino acid biosynthetic process methionine biosynthetic process lyase activity L-methionine biosynthetic process from S-adenosylmethionine L-methionine biosynthetic process from methylthioadenosine identical protein binding negative regulation of apoptotic process methylthioribulose 1-phosphate dehydratase activity metal ion binding protein homotetramerization pyroptosis regulation of ERK1 and ERK2 cascade uc008lin.1 uc008lin.2 uc008lin.3 uc008lin.4 
ENSMUST00000011058.9 Pdhx ENSMUST00000011058.9 pyruvate dehydrogenase complex, component X (from RefSeq NM_175094.5) ENSMUST00000011058.1 ENSMUST00000011058.2 ENSMUST00000011058.3 ENSMUST00000011058.4 ENSMUST00000011058.5 ENSMUST00000011058.6 ENSMUST00000011058.7 ENSMUST00000011058.8 NM_175094 ODPX_MOUSE Q8BKZ9 uc008lil.1 uc008lil.2 uc008lil.3 uc008lil.4 uc008lil.5 uc008lil.6 Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex (By similarity). Part of the inner core of the multimeric pyruvate dehydrogenase complex that is composed of about 48 DLAT and 12 PDHX molecules. This core binds multiple copies of pyruvate dehydrogenase (subunits PDH1A and PDHB, E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). Interacts with SIRT4. Interacts with DLD. Mitochondrion matrix Delipoylated at Lys-97 by SIRT4, delipoylation decreases the PHD complex activity. Belongs to the 2-oxoacid dehydrogenase family. mitochondrion mitochondrial matrix transferase activity, transferring acyl groups pyruvate dehydrogenase (NAD+) activity pyruvate dehydrogenase complex mitochondrial acetyl-CoA biosynthetic process from pyruvate uc008lil.1 uc008lil.2 uc008lil.3 uc008lil.4 uc008lil.5 uc008lil.6 
ENSMUST00000011178.5 Slc5a1 ENSMUST00000011178.5 solute carrier family 5 (sodium/glucose cotransporter), member 1 (from RefSeq NM_019810.4) ENSMUST00000011178.1 ENSMUST00000011178.2 ENSMUST00000011178.3 ENSMUST00000011178.4 NM_019810 Q9QXI6 Q9QXI6_MOUSE Sglt1 Slc5a1 uc008xah.1 uc008xah.2 uc008xah.3 uc008xah.4 Reaction=D-galactose(out) + 2 Na(+)(out) = D-galactose(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70499, ChEBI:CHEBI:4139, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70500; Evidence=; Reaction=D-glucose(out) + 2 Na(+)(out) = D-glucose(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70495, ChEBI:CHEBI:4167, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70496; Evidence=; Apical cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. glucose:sodium symporter activity cell-cell junction membrane integral component of membrane apical plasma membrane transmembrane transporter activity brush border membrane transmembrane transport glucose transmembrane transport uc008xah.1 uc008xah.2 uc008xah.3 uc008xah.4 
ENSMUST00000011262.4 Panx3 ENSMUST00000011262.4 pannexin 3 (from RefSeq NM_172454.2) ENSMUST00000011262.1 ENSMUST00000011262.2 ENSMUST00000011262.3 NM_172454 PANX3_MOUSE Q8CB28 Q8CEG0 uc009ovi.1 uc009ovi.2 uc009ovi.3 Structural component of the gap junctions and the hemichannels. Cell membrane ; Multi-pass membrane protein Cell junction, gap junction. Expressed in skin, cartilage, heart, lung, liver, spleen, thymus and kidney. Not expressed in brain. N-glycosylation may play a role in cell surface targeting. Belongs to the pannexin family. plasma membrane gap junction ion transport cation transport cell-cell signaling channel activity membrane integral component of membrane wide pore channel activity cell junction protein hexamerization positive regulation of interleukin-1 secretion gap junction hemi-channel activity transmembrane transport uc009ovi.1 uc009ovi.2 uc009ovi.3 
ENSMUST00000011298.14 Cfap161 ENSMUST00000011298.14 cilia and flagella associated protein 161 (from RefSeq NM_029335.3) CF161_MOUSE Cfap161 ENSMUST00000011298.1 ENSMUST00000011298.10 ENSMUST00000011298.11 ENSMUST00000011298.12 ENSMUST00000011298.13 ENSMUST00000011298.2 ENSMUST00000011298.3 ENSMUST00000011298.4 ENSMUST00000011298.5 ENSMUST00000011298.6 ENSMUST00000011298.7 ENSMUST00000011298.8 ENSMUST00000011298.9 NM_029335 Q6P8Y0 Q9D9X1 uc009idv.1 uc009idv.2 uc009idv.3 uc009idv.4 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Cytoplasm, cytoskeleton, cilium axoneme molecular_function cellular_component biological_process membrane uc009idv.1 uc009idv.2 uc009idv.3 uc009idv.4 
ENSMUST00000011302.9 Brf1 ENSMUST00000011302.9 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit (from RefSeq NM_028193.3) Brf1 ENSMUST00000011302.1 ENSMUST00000011302.2 ENSMUST00000011302.3 ENSMUST00000011302.4 ENSMUST00000011302.5 ENSMUST00000011302.6 ENSMUST00000011302.7 ENSMUST00000011302.8 G3X8S2 G3X8S2_MOUSE NM_028193 uc007pfn.1 uc007pfn.2 uc007pfn.3 Nucleus Belongs to the TFIIB family. translation initiation factor activity regulation of transcription, DNA-templated translational initiation TBP-class protein binding positive regulation of transcription from RNA polymerase III promoter metal ion binding DNA-templated transcriptional preinitiation complex assembly uc007pfn.1 uc007pfn.2 uc007pfn.3 
ENSMUST00000011315.10 Vipr2 ENSMUST00000011315.10 vasoactive intestinal peptide receptor 2, transcript variant 1 (from RefSeq NM_009511.2) ENSMUST00000011315.1 ENSMUST00000011315.2 ENSMUST00000011315.3 ENSMUST00000011315.4 ENSMUST00000011315.5 ENSMUST00000011315.6 ENSMUST00000011315.7 ENSMUST00000011315.8 ENSMUST00000011315.9 NM_009511 Q546Q8 Q546Q8_MOUSE Vipr2 uc007phf.1 uc007phf.2 uc007phf.3 uc007phf.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 2 family. transmembrane signaling receptor activity G-protein coupled receptor activity vasoactive intestinal polypeptide receptor activity signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway activation of adenylate cyclase activity membrane integral component of membrane negative regulation of smooth muscle cell proliferation uc007phf.1 uc007phf.2 uc007phf.3 uc007phf.4 
ENSMUST00000011398.13 Thg1l ENSMUST00000011398.13 tRNA-histidine guanylyltransferase 1-like (S. cerevisiae), transcript variant 1 (from RefSeq NM_001080969.3) ENSMUST00000011398.1 ENSMUST00000011398.10 ENSMUST00000011398.11 ENSMUST00000011398.12 ENSMUST00000011398.2 ENSMUST00000011398.3 ENSMUST00000011398.4 ENSMUST00000011398.5 ENSMUST00000011398.6 ENSMUST00000011398.7 ENSMUST00000011398.8 ENSMUST00000011398.9 NM_001080969 Q562D7 Q9CY52 THG1_MOUSE uc007inv.1 uc007inv.2 uc007inv.3 uc007inv.4 uc007inv.5 Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress. Reaction=a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+); Xref=Rhea:RHEA:54564, Rhea:RHEA-COMP:14193, Rhea:RHEA- COMP:14917, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:138282, ChEBI:CHEBI:141847, ChEBI:CHEBI:456215; EC=2.7.7.79; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions per subunit. ; Homotetramer. Interacts with MFN1 and MFN2; functions as a guanyl-nucleotide exchange factor/GEF for MFN2 and also probably MFN1. Cytoplasm. Mitochondrion Belongs to the tRNA(His) guanylyltransferase family. nucleotide binding magnesium ion binding ATP binding GTP binding cytoplasm mitochondrion tRNA modification tRNA processing tRNA guanylyltransferase activity transferase activity nucleotidyltransferase activity identical protein binding metal ion binding protein homotetramerization tRNA 5'-end processing transferase complex uc007inv.1 uc007inv.2 uc007inv.3 uc007inv.4 uc007inv.5 
ENSMUST00000011400.8 Adam19 ENSMUST00000011400.8 ADAM metallopeptidase domain 19, transcript variant 1 (from RefSeq NM_009616.4) Adam19 ENSMUST00000011400.1 ENSMUST00000011400.2 ENSMUST00000011400.3 ENSMUST00000011400.4 ENSMUST00000011400.5 ENSMUST00000011400.6 ENSMUST00000011400.7 NM_009616 Q3UHT3 Q3UHT3_MOUSE uc007iny.1 uc007iny.2 uc007iny.3 uc007iny.4 This gene encodes a cell surface glycoprotein and member of the ADAM (a disintegrin and metalloproteinase) family of endopeptidases. The encoded protein may play a role in the ectodomain shedding of neuregulin proteins. Homozygous knockout mice for this gene exhibit heart development defects and perinatal lethality. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that undergoes proteolytic processing to generate a mature protein product. [provided by RefSeq, Aug 2015]. Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. metalloendopeptidase activity Golgi apparatus proteolysis membrane protein ectodomain proteolysis integrin-mediated signaling pathway metallopeptidase activity membrane integral component of membrane SH3 domain binding uc007iny.1 uc007iny.2 uc007iny.3 uc007iny.4 
ENSMUST00000011445.8 Cd209d ENSMUST00000011445.8 CD209d antigen (from RefSeq NM_130904.2) C209D_MOUSE ENSMUST00000011445.1 ENSMUST00000011445.2 ENSMUST00000011445.3 ENSMUST00000011445.4 ENSMUST00000011445.5 ENSMUST00000011445.6 ENSMUST00000011445.7 NM_130904 Q8VIK4 Q91ZW8 uc009kst.1 uc009kst.2 uc009kst.3 Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91ZW8-1; Sequence=Displayed; Name=2; IsoId=Q91ZW8-2; Sequence=VSP_010071; In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified. Name=Functional Glycomics Gateway - Glycan Binding; Note=SIGNR3; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_00132"; mannose binding endocytosis membrane integral component of membrane carbohydrate binding defense response to bacterium protein homodimerization activity metal ion binding positive regulation of cytokine secretion uc009kst.1 uc009kst.2 uc009kst.3 
ENSMUST00000011450.8 Sugp1 ENSMUST00000011450.8 SURP and G patch domain containing 1, transcript variant 1 (from RefSeq NM_027481.3) ENSMUST00000011450.1 ENSMUST00000011450.2 ENSMUST00000011450.3 ENSMUST00000011450.4 ENSMUST00000011450.5 ENSMUST00000011450.6 ENSMUST00000011450.7 NM_027481 Q0VAT9 Q3U0W3 Q8CH02 Q8R094 SUGP1_MOUSE Sf4 uc009lyo.1 uc009lyo.2 uc009lyo.3 Plays a role in pre-mRNA splicing. Component of the spliceosome. Nucleus nucleic acid binding RNA binding nucleus nucleoplasm spliceosomal complex RNA processing mRNA processing RNA splicing uc009lyo.1 uc009lyo.2 uc009lyo.3 
ENSMUST00000011492.15 Acad9 ENSMUST00000011492.15 acyl-Coenzyme A dehydrogenase family, member 9 (from RefSeq NM_172678.4) ACAD9_MOUSE Acad9 ENSMUST00000011492.1 ENSMUST00000011492.10 ENSMUST00000011492.11 ENSMUST00000011492.12 ENSMUST00000011492.13 ENSMUST00000011492.14 ENSMUST00000011492.2 ENSMUST00000011492.3 ENSMUST00000011492.4 ENSMUST00000011492.5 ENSMUST00000011492.6 ENSMUST00000011492.7 ENSMUST00000011492.8 ENSMUST00000011492.9 NM_172678 Q3ULL9 Q8BK76 Q8C0B5 Q8JZN5 uc008oze.1 uc008oze.2 uc008oze.3 As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation. This moonlighting protein has also a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs. However, in vivo, it does not seem to play a primary role in fatty acid oxidation. In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein. Reaction=eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47236, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57380, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:74691; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47237; Evidence=; Reaction=H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47240, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57394, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:71412; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47241; Evidence=; Reaction=H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:43448, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57379, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:61526; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43449; Evidence=; Reaction=decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:48176, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:61406, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48177; Evidence=; Reaction=H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:48208, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:76291, ChEBI:CHEBI:76292; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48209; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:48204, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:74309, ChEBI:CHEBI:77545; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48205; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl- CoA = reduced [electron-transfer flavoprotein] + trans-2-undecenoyl- CoA; Xref=Rhea:RHEA:48200, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:77547, ChEBI:CHEBI:77548; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48201; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-hexadecadienoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:47304, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:61540, ChEBI:CHEBI:77549; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47305; Evidence=; Reaction=H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = reduced [electron-transfer flavoprotein] + trans-2- heptadecenoyl-CoA; Xref=Rhea:RHEA:48196, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:74307, ChEBI:CHEBI:77551; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48197; Evidence=; Reaction=(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9E)-octadecadienoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:48192, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:77537, ChEBI:CHEBI:77552; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48193; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-octadecadienoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:47300, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57387, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:77553; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47301; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron- transfer flavoprotein] = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:48188, Rhea:RHEA- COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57383, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:77558; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48189; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,4Z,7Z,10Z,13Z,16Z,19Z)- docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:48184, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:74298, ChEBI:CHEBI:77559; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48185; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:47316, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57385, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:61405; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47317; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Homodimer (By similarity). Interacts with NDUFAF1 and ECSIT (By similarity). Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186 (By similarity). Interacts with TMEM70 and TMEM242 (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Note=Essentially associated with membranes. Belongs to the acyl-CoA dehydrogenase family. fatty-acyl-CoA binding long-chain fatty acid metabolic process acyl-CoA dehydrogenase activity long-chain-acyl-CoA dehydrogenase activity nucleus mitochondrion oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors very-long-chain-acyl-CoA dehydrogenase activity dendrite mitochondrial membrane mitochondrial respiratory chain complex I assembly flavin adenine dinucleotide binding medium-chain fatty acid metabolic process oxidation-reduction process medium-chain-acyl-CoA dehydrogenase activity uc008oze.1 uc008oze.2 uc008oze.3 
ENSMUST00000011493.6 Dmrtc2 ENSMUST00000011493.6 doublesex and mab-3 related transcription factor like family C2 (from RefSeq NM_027732.2) A6H6T0 DMRTD_MOUSE Dmrt7 ENSMUST00000011493.1 ENSMUST00000011493.2 ENSMUST00000011493.3 ENSMUST00000011493.4 ENSMUST00000011493.5 NM_027732 Q8CGW9 uc009fqp.1 uc009fqp.2 uc009fqp.3 May be involved in sexual development. Nucleus Expressed in testis. Highly expressed in ovary. Expressed in gonads from 11.5 dpc. Belongs to the DMRT family. XY body DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated male meiosis I spermatid nucleus elongation sex differentiation cell differentiation protein homodimerization activity sequence-specific DNA binding metal ion binding positive regulation of histone H3-K9 dimethylation positive regulation of histone H3-K9 trimethylation uc009fqp.1 uc009fqp.2 uc009fqp.3 
ENSMUST00000011526.7 Dhdh ENSMUST00000011526.7 dihydrodiol dehydrogenase (from RefSeq NM_027903.4) DHDH_MOUSE ENSMUST00000011526.1 ENSMUST00000011526.2 ENSMUST00000011526.3 ENSMUST00000011526.4 ENSMUST00000011526.5 ENSMUST00000011526.6 NM_027903 Q14B09 Q9DBB8 uc009gvj.1 uc009gvj.2 uc009gvj.3 Reaction=(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH; Xref=Rhea:RHEA:16729, ChEBI:CHEBI:10702, ChEBI:CHEBI:15378, ChEBI:CHEBI:18135, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.20; Reaction=D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH; Xref=Rhea:RHEA:22000, ChEBI:CHEBI:15378, ChEBI:CHEBI:15867, ChEBI:CHEBI:53455, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.179; Homodimer. Belongs to the Gfo/Idh/MocA family. oxidoreductase activity D-xylose catabolic process trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity D-xylose 1-dehydrogenase (NADP+) activity oxidation-reduction process uc009gvj.1 uc009gvj.2 uc009gvj.3 
ENSMUST00000011607.6 Cpb1 ENSMUST00000011607.6 carboxypeptidase B1 (from RefSeq NM_029706.2) B2RS76 B2RS76_MOUSE Cpb1 ENSMUST00000011607.1 ENSMUST00000011607.2 ENSMUST00000011607.3 ENSMUST00000011607.4 ENSMUST00000011607.5 NM_029706 uc008osq.1 uc008osq.2 uc008osq.3 uc008osq.4 Reaction=Preferential release of a C-terminal lysine or arginine amino acid.; EC=3.4.17.2; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Secreted Zymogen granule lumen Belongs to the peptidase M14 family. carboxypeptidase activity metallocarboxypeptidase activity extracellular space proteolysis zinc ion binding uc008osq.1 uc008osq.2 uc008osq.3 uc008osq.4 
ENSMUST00000011623.9 Dennd1c ENSMUST00000011623.9 DENN domain containing 1C, transcript variant 1 (from RefSeq NM_153551.2) DEN1C_MOUSE ENSMUST00000011623.1 ENSMUST00000011623.2 ENSMUST00000011623.3 ENSMUST00000011623.4 ENSMUST00000011623.5 ENSMUST00000011623.6 ENSMUST00000011623.7 ENSMUST00000011623.8 NM_153551 Q8CFK6 Q9CXF1 uc008ddy.1 uc008ddy.2 Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Exhibits low nucleotide-independent RAB35-binding activity. Interacts with clathrin heavy chain/CLTC and with AP2A2, but not with AP2B1. Cytoplasm, cytosol Cytoplasmic vesicle, clathrin-coated vesicle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CFK6-1; Sequence=Displayed; Name=2; IsoId=Q8CFK6-2; Sequence=VSP_028091, VSP_028092; guanyl-nucleotide exchange factor activity cytoplasm cytosol endocytosis Rab guanyl-nucleotide exchange factor activity Rab GTPase binding clathrin-coated vesicle cytoplasmic vesicle endocytic recycling intracellular membrane-bounded organelle phosphatidylinositol phosphate binding uc008ddy.1 uc008ddy.2 
ENSMUST00000011733.9 Fsd1 ENSMUST00000011733.9 fibronectin type 3 and SPRY domain-containing protein, transcript variant 10 (from RefSeq NR_177196.1) ENSMUST00000011733.1 ENSMUST00000011733.2 ENSMUST00000011733.3 ENSMUST00000011733.4 ENSMUST00000011733.5 ENSMUST00000011733.6 ENSMUST00000011733.7 ENSMUST00000011733.8 FSD1_MOUSE NR_177196 Q3UNE6 Q7TPM6 uc008dan.1 uc008dan.2 May be involved in microtubule organization and stabilization. Oligomerization is required for binding to microtubules. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Cytoplasm Cleavage furrow Note=Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associate with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TPM6-1; Sequence=Displayed; Name=2; IsoId=Q7TPM6-2; Sequence=VSP_030767; B30.2 box contains a microtubule-binding site. nucleus cytoplasm centrosome microtubule organizing center cytoskeleton microtubule cell cycle microtubule binding cytoplasmic microtubule organization cleavage furrow regulation of cytokinesis protein homodimerization activity protein homooligomerization cell division regulation of cell division regulation of mitotic spindle organization uc008dan.1 uc008dan.2 
ENSMUST00000011776.8 Pinlyp ENSMUST00000011776.8 phospholipase A2 inhibitor and LY6/PLAUR domain containing (from RefSeq NM_001037143.3) ENSMUST00000011776.1 ENSMUST00000011776.2 ENSMUST00000011776.3 ENSMUST00000011776.4 ENSMUST00000011776.5 ENSMUST00000011776.6 ENSMUST00000011776.7 NM_001037143 PINLY_MOUSE Q9CQD7 Q9D6V5 uc009fpw.1 uc009fpw.2 uc009fpw.3 Secreted Belongs to the CNF-like-inhibitor family. molecular_function phospholipase inhibitor activity cellular_component extracellular region biological_process negative regulation of catalytic activity uc009fpw.1 uc009fpw.2 uc009fpw.3 
ENSMUST00000011895.14 Sptbn4 ENSMUST00000011895.14 spectrin beta, non-erythrocytic 4, transcript variant sigma1 (from RefSeq NM_032610.2) E9PX29 E9PX29_MOUSE ENSMUST00000011895.1 ENSMUST00000011895.10 ENSMUST00000011895.11 ENSMUST00000011895.12 ENSMUST00000011895.13 ENSMUST00000011895.2 ENSMUST00000011895.3 ENSMUST00000011895.4 ENSMUST00000011895.5 ENSMUST00000011895.6 ENSMUST00000011895.7 ENSMUST00000011895.8 ENSMUST00000011895.9 NM_032610 Spnb4 Sptbn4 uc009fwc.1 uc009fwc.2 uc009fwc.3 Belongs to the spectrin family. regulation of sodium ion transport actin binding structural constituent of cytoskeleton protein binding phospholipid binding cytoplasm cytoskeleton cytoskeleton organization axonogenesis sensory perception of sound adult walking behavior spectrin fertilization negative regulation of heart rate intercalated disc membrane nuclear matrix PML body transmission of nerve impulse phosphatase binding central nervous system projection neuron axonogenesis reproductive process axon ankyrin binding spectrin binding adult behavior regulation of peptidyl-serine phosphorylation node of Ranvier paranode region of axon cellular protein localization positive regulation of multicellular organism growth neuronal cell body axon initial segment axon hillock clustering of voltage-gated sodium channels actin filament capping cardiac conduction cell body fiber uc009fwc.1 uc009fwc.2 uc009fwc.3 
ENSMUST00000011896.8 Pgam1 ENSMUST00000011896.8 phosphoglycerate mutase 1 (from RefSeq NM_023418.2) ENSMUST00000011896.1 ENSMUST00000011896.2 ENSMUST00000011896.3 ENSMUST00000011896.4 ENSMUST00000011896.5 ENSMUST00000011896.6 ENSMUST00000011896.7 NM_023418 PGAM1_MOUSE Pgam1 Q9D6W0 Q9DBJ1 Q9ERT3 uc008hml.1 uc008hml.2 uc008hml.3 uc008hml.4 Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglyceratea crucial step in glycolysis, by using 2,3- bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3- bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate. Reaction=(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; Xref=Rhea:RHEA:15901, ChEBI:CHEBI:58272, ChEBI:CHEBI:58289; EC=5.4.2.11; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:15903; Evidence=; Reaction=(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3- bisphosphoglycerate + H(+); Xref=Rhea:RHEA:17765, ChEBI:CHEBI:15378, ChEBI:CHEBI:57604, ChEBI:CHEBI:58248; EC=5.4.2.4; Evidence=; Homodimer. Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme (By similarity). Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. catalytic activity bisphosphoglycerate mutase activity phosphoglycerate mutase activity nucleus cytoplasm cytosol glycolytic process regulation of glycolytic process hydrolase activity isomerase activity intramolecular transferase activity, phosphotransferases protein kinase binding myelin sheath regulation of pentose-phosphate shunt respiratory burst uc008hml.1 uc008hml.2 uc008hml.3 uc008hml.4 
ENSMUST00000011981.5 Snapc2 ENSMUST00000011981.5 small nuclear RNA activating complex, polypeptide 2 (from RefSeq NM_133968.1) ENSMUST00000011981.1 ENSMUST00000011981.2 ENSMUST00000011981.3 ENSMUST00000011981.4 NM_133968 Q3UK17 Q8CBS9 Q91XA5 SNPC2_MOUSE uc009kto.1 uc009kto.2 uc009kto.3 Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity). Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and SNAPC4 (By similarity). Nucleus molecular_function nucleus nucleoplasm cytosol biological_process nuclear body uc009kto.1 uc009kto.2 uc009kto.3 
ENSMUST00000012028.14 Gltp ENSMUST00000012028.14 glycolipid transfer protein (from RefSeq NM_019821.2) ENSMUST00000012028.1 ENSMUST00000012028.10 ENSMUST00000012028.11 ENSMUST00000012028.12 ENSMUST00000012028.13 ENSMUST00000012028.2 ENSMUST00000012028.3 ENSMUST00000012028.4 ENSMUST00000012028.5 ENSMUST00000012028.6 ENSMUST00000012028.7 ENSMUST00000012028.8 ENSMUST00000012028.9 GLTP_MOUSE NM_019821 Q91YJ7 Q9CTK9 Q9JL62 uc008yzw.1 uc008yzw.2 uc008yzw.3 uc008yzw.4 uc008yzw.5 Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides (By similarity). Monomer. Cytoplasm Belongs to the GLTP family. cytoplasm cytosol lipid transport lipid binding ceramide transport identical protein binding glycolipid binding ceramide 1-phosphate binding ceramide 1-phosphate transporter activity ceramide 1-phosphate transport uc008yzw.1 uc008yzw.2 uc008yzw.3 uc008yzw.4 uc008yzw.5 
ENSMUST00000012152.13 Dgcr2 ENSMUST00000012152.13 DiGeorge syndrome critical region gene 2, transcript variant 1 (from RefSeq NM_010048.3) Dgcr2 ENSMUST00000012152.1 ENSMUST00000012152.10 ENSMUST00000012152.11 ENSMUST00000012152.12 ENSMUST00000012152.2 ENSMUST00000012152.3 ENSMUST00000012152.4 ENSMUST00000012152.5 ENSMUST00000012152.6 ENSMUST00000012152.7 ENSMUST00000012152.8 ENSMUST00000012152.9 NM_010048 Q6P5A9 Q6P5A9_MOUSE uc033gyb.1 uc033gyb.2 uc033gyb.3 uc033gyb.4 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc033gyb.1 uc033gyb.2 uc033gyb.3 uc033gyb.4 
ENSMUST00000012161.5 Scarf2 ENSMUST00000012161.5 scavenger receptor class F, member 2 (from RefSeq NM_153790.3) ENSMUST00000012161.1 ENSMUST00000012161.2 ENSMUST00000012161.3 ENSMUST00000012161.4 NM_153790 NSR1 Q58A84 Q58A84_MOUSE Scarf2 uc007ymd.1 uc007ymd.2 uc007ymd.3 Lacks conserved residue(s) required for the propagation of feature annotation. heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules uc007ymd.1 uc007ymd.2 uc007ymd.3 
ENSMUST00000012259.9 Med15 ENSMUST00000012259.9 mediator complex subunit 15, transcript variant 1 (from RefSeq NM_033609.3) ENSMUST00000012259.1 ENSMUST00000012259.2 ENSMUST00000012259.3 ENSMUST00000012259.4 ENSMUST00000012259.5 ENSMUST00000012259.6 ENSMUST00000012259.7 ENSMUST00000012259.8 G3X8S4 MED15_MOUSE NM_033609 Pcqap Q924H2 uc007yls.1 uc007yls.2 uc007yls.3 uc007yls.4 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol- dependent gene regulation. Positively regulates the Nodal signaling pathway (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with SMAD2, SMAD3, SREBF1 and SREBF2. Interacts with WWTR1 (By similarity). Interacts with TRIM11 (By similarity). Cytoplasm Nucleus At 9.5 dpc ubiquitously expressed at low levels with slightly elevated levels in the pharyngeal arches and in the forelimb buds. At 10.5 dpc expression was more pronounced in the first and second pharyngeal arches, the nasal processes and the limb buds. At 11.5 dpc expression is high in frontonasal region, maxillary and mandibular processes of the first and second pharyngeal arch and developing fore and hindlimbs. From 11.5 dpc-12.5 dpc expression is seen in the distal parts of the developing limbs and in the facial region. At 12.5 dpc transcripts were found in the developing hair follicles of the vibrissae. Ubiquitinated by TRIM11, leading to proteasomal degradation. Belongs to the Mediator complex subunit 15 family. Sequence=AAK58424.1; Type=Frameshift; Evidence=; transcription cofactor activity nucleus nucleoplasm cytoplasm regulation of transcription from RNA polymerase II promoter mediator complex stem cell population maintenance uc007yls.1 uc007yls.2 uc007yls.3 uc007yls.4 
ENSMUST00000012279.6 Gsc2 ENSMUST00000012279.6 goosecoid homebox 2 (from RefSeq NM_029469.2) A2RTU1 ENSMUST00000012279.1 ENSMUST00000012279.2 ENSMUST00000012279.3 ENSMUST00000012279.4 ENSMUST00000012279.5 GSC2_MOUSE Gscl NM_029469 P56916 Q05A98 uc289dar.1 uc289dar.2 May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC. Nucleus Expressed in adult testis. Has a biphasic expression. Present in embryos in 8.5-10.5 dpc, reduced levels in 11.5 dpc and 13.5 dpc and absent in 15.5 dpc. Found in some adult tissues. Belongs to the paired homeobox family. Bicoid subfamily. Sequence=AAI32638.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding uc289dar.1 uc289dar.2 
ENSMUST00000012281.8 Bmp5 ENSMUST00000012281.8 bone morphogenetic protein 5 (from RefSeq NM_007555.4) BMP5_MOUSE Bmp-5 ENSMUST00000012281.1 ENSMUST00000012281.2 ENSMUST00000012281.3 ENSMUST00000012281.4 ENSMUST00000012281.5 ENSMUST00000012281.6 ENSMUST00000012281.7 NM_007555 P49003 Q8CCE0 uc009qsu.1 uc009qsu.2 uc009qsu.3 uc009qsu.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Mice with null mutations in this gene exhibit a short ear phenotype, which is characterized by reduced size of the external ear, altered size and shape of the sternum, and other skeletal and soft-tissue abnormalities. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.230095.1, AK160412.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:7958439, PubMed:29321139). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (By similarity). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509). Interacts with ERFE; the interaction inhibits BMP-induced transcription of HAMP. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P49003-1; Sequence=Displayed; Name=2; IsoId=P49003-2; Sequence=VSP_044321; Deletion mutant mice show a number of skeletal defects, including small ears, several reduced vertebral processes, and a reduced number of ribs and sesamoid bones (PubMed:7958439). BMP5/7- deficient mice lack midbrain dopaminergic neurons due to reduced neurogenesis in the midbrain dopaminergic progenitor domain (PubMed:29321139). Belongs to the TGF-beta family. skeletal system development ossification endocardial cushion formation type B pancreatic cell development pericardium morphogenesis cytokine activity transforming growth factor beta receptor binding protein binding extracellular region extracellular space multicellular organism development pattern specification process growth factor activity positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of steroid biosynthetic process neural fold elevation formation cell differentiation male genitalia development hindbrain development vesicle negative regulation of aldosterone biosynthetic process regulation of apoptotic process regulation of MAPK cascade negative regulation of insulin-like growth factor receptor signaling pathway ear development positive regulation of transcription from RNA polymerase II promoter cell development cardiac muscle tissue development positive regulation of epithelial cell proliferation cartilage development pharyngeal system development SMAD protein signal transduction cardiac septum morphogenesis chorio-allantoic fusion heart trabecula morphogenesis BMP receptor binding anterior head development positive regulation of dendrite development allantois development negative regulation of cortisol biosynthetic process uc009qsu.1 uc009qsu.2 uc009qsu.3 uc009qsu.4 
ENSMUST00000012314.10 Zfp729a ENSMUST00000012314.10 zinc finger protein 729a, transcript variant 1 (from RefSeq NM_183146.5) A530054K11Rik ENSMUST00000012314.1 ENSMUST00000012314.2 ENSMUST00000012314.3 ENSMUST00000012314.4 ENSMUST00000012314.5 ENSMUST00000012314.6 ENSMUST00000012314.7 ENSMUST00000012314.8 ENSMUST00000012314.9 NM_183146 Q4QQP3 Q4QQP3_MOUSE Zfp729a uc007rbh.1 uc007rbh.2 uc007rbh.3 nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated biological_process metal ion binding uc007rbh.1 uc007rbh.2 uc007rbh.3 
ENSMUST00000012348.9 Gstm2 ENSMUST00000012348.9 glutathione S-transferase, mu 2 (from RefSeq NM_008183.4) ENSMUST00000012348.1 ENSMUST00000012348.2 ENSMUST00000012348.3 ENSMUST00000012348.4 ENSMUST00000012348.5 ENSMUST00000012348.6 ENSMUST00000012348.7 ENSMUST00000012348.8 GSTM2_MOUSE Gstm2 NM_008183 P15626 uc008qxw.1 uc008qxw.2 uc008qxw.3 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16438; Evidence=; Reaction=11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)- eicosatrienoate; Xref=Rhea:RHEA:50260, ChEBI:CHEBI:57925, ChEBI:CHEBI:132200, ChEBI:CHEBI:132201; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50261; Evidence=; Homodimer. Cytoplasm. Belongs to the GST superfamily. Mu family. glutathione transferase activity protein binding cytoplasm cytosol plasma membrane glutathione metabolic process transferase activity nitrobenzene metabolic process enzyme binding macromolecular complex xenobiotic catabolic process protein homodimerization activity glutathione binding intercellular bridge cellular detoxification of nitrogen compound uc008qxw.1 uc008qxw.2 uc008qxw.3 
ENSMUST00000012426.3 Wnt8a ENSMUST00000012426.3 wingless-type MMTV integration site family, member 8A (from RefSeq NM_009290.3) E9QL90 ENSMUST00000012426.1 ENSMUST00000012426.2 NM_009290 Q64527 Stra11 WNT8A_MOUSE Wnt8d uc008ekq.1 uc008ekq.2 uc008ekq.3 uc008ekq.4 Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids. Secreted, extracellular space, extracellular matrix Secreted Expression in early stages of embryogenesis. Expression begins in the posterior region of early primitive streak- stage embryos and after it spreads into the embryonic ectoderm up to a sharp rostral boundary at the base of the developing headfolds. Expressed transiently in the newly formed mesoderm. Expression is down- regulated during somitogenesis. The expression is highly restricted during gastrulation and neurulation, both temporally and spatially. By retinoic acid. Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity). Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8A. Belongs to the Wnt family. cell morphogenesis regionalization receptor binding frizzled binding protein binding extracellular region extracellular space multicellular organism development endoderm development polarity specification of anterior/posterior axis polarity specification of proximal/distal axis Wnt signaling pathway neuron differentiation regulation of protein localization cell fate commitment receptor agonist activity establishment of animal organ orientation canonical Wnt signaling pathway uc008ekq.1 uc008ekq.2 uc008ekq.3 uc008ekq.4 
ENSMUST00000012540.5 Nanog ENSMUST00000012540.5 Nanog homeobox, transcript variant 1 (from RefSeq NM_028016.3) ENSMUST00000012540.1 ENSMUST00000012540.2 ENSMUST00000012540.3 ENSMUST00000012540.4 Ecat4 Enk NANOG_MOUSE NM_028016 Q6SMR1 Q7TN85 Q80Z64 uc029vyl.1 uc029vyl.2 uc029vyl.3 uc029vyl.4 The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal (PubMed:25825768). Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'- TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (By similarity). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. Interacts with SMAD1 (PubMed:16801560). Interacts with SALL4 (PubMed:16840789). Interacts with ZNF281/ZFP281 (PubMed:21915945, PubMed:22988117). Interacts with PCGF1 (By similarity). Interacts with ESRRB; reciprocally modulates their transcriptional activities (PubMed:18957414). Interacts with NSD2 (PubMed:19483677). Q80Z64; Q61066: Nr0b1; NbExp=7; IntAct=EBI-2312517, EBI-2312665; Q80Z64; Q9QUR7: Pin1; NbExp=2; IntAct=EBI-2312517, EBI-2432975; Q80Z64; P20263: Pou5f1; NbExp=4; IntAct=EBI-2312517, EBI-1606219; Q80Z64; Q6PR54: Rif1; NbExp=5; IntAct=EBI-2312517, EBI-2312621; Q80Z64; P70414: Slc8a1; NbExp=9; IntAct=EBI-2312517, EBI-2312694; Q80Z64; P48432: Sox2; NbExp=10; IntAct=EBI-2312517, EBI-2313612; Q80Z64; Q99LI5: Znf281; NbExp=5; IntAct=EBI-2312517, EBI-2312719; Q80Z64-1; Q80Z64-1: Nanog; NbExp=2; IntAct=EBI-15699014, EBI-15699014; Q80Z64-1; P62991: Ubc; NbExp=3; IntAct=EBI-15699014, EBI-413074; Q80Z64-1; Q13526: PIN1; Xeno; NbExp=2; IntAct=EBI-15699014, EBI-714158; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80Z64-1; Sequence=Displayed; Name=2; Synonyms=Nanog1a, Nanog1b; IsoId=Q80Z64-2; Sequence=VSP_021689; Not expressed in oocytes and spermatogonia (at protein level). Not expressed in many somatic organs, ovary, testis, fibroblast and hematopoietic cell lines. Expressed in the central portion of the morula, the inner cell mass (ICM) of the blastocyst, in embryonic stem (ES) and embryonic germ (EG) cells, in the epiblast between 6.5 and 7.5 dpc, in primordial germ cells (PGCs) between 7.75 and 12.5 dpc (at protein level). The expression in PGCs decreases in female germ cells that entered meiosis at 13.5 dpc and in male germ cells that entered mitotic arrest at 14.5 dpc (at protein level). Not expressed in unfertilized eggs or 2- or 8-cell-stage embryos (at protein level). Expressed in the central portion of the morula, the inner cell mass (ICM) of the blastocyst, in ES and EG cells, in the epiblast at 6 dpc and in PGCs of genital ridges between 11.5 and 12.5 dpc. Expression decreases with ES differentiation. By the transcription factor POU5F1 in ES cells that acts as a direct biphasic regulator: a steady-state concentration of POU5F1 up- regulated its expression, while an elevated concentration of POU5F1 down-regulated its expression. Up-regulated by the transcription factor FOXD3. Up-regulated in ES cells by transcription factors T (Brachyury) and STAT3. Down-regulated by p53 in response to DNA damage induced by ultraviolet light (UV) or doxorubicin. Down-regulated upon ES differentiation by mediating autorepression through interaction with ZNF281/ZFP281. Loss of pluripotency in both ICM and ES cells and differentiated into extraembryonic (parietal and visceral) endoderm lineage. 'Nanog' is derived from 'Tir nan Og' the mythologic Celtic land of the ever young. Belongs to the Nanog homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription factor recruiting enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding mesodermal cell fate commitment endodermal cell fate specification DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus nucleoplasm nucleolus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development transcription factor binding positive regulation of cell proliferation gonad development embryonic pattern specification response to organic substance negative regulation of cell fate commitment regulation of gene expression stem cell division stem cell population maintenance negative regulation of BMP signaling pathway response to retinoic acid somatic stem cell population maintenance negative regulation of endodermal cell fate specification identical protein binding sequence-specific DNA binding cell dedifferentiation transcription regulatory region DNA binding regulation of cell differentiation negative regulation of cell differentiation positive regulation of transcription, DNA-templated positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter stem cell differentiation regulation of stem cell division positive regulation of stem cell proliferation condensed chromosome uc029vyl.1 uc029vyl.2 uc029vyl.3 uc029vyl.4 
ENSMUST00000012580.13 Hps3 ENSMUST00000012580.13 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1, transcript variant 12 (from RefSeq NR_176915.1) Coa ENSMUST00000012580.1 ENSMUST00000012580.10 ENSMUST00000012580.11 ENSMUST00000012580.12 ENSMUST00000012580.2 ENSMUST00000012580.3 ENSMUST00000012580.4 ENSMUST00000012580.5 ENSMUST00000012580.6 ENSMUST00000012580.7 ENSMUST00000012580.8 ENSMUST00000012580.9 HPS3_MOUSE NR_176915 Q6GTD8 Q8VDX2 Q8VHT1 Q91VB4 uc008osf.1 uc008osf.2 uc008osf.3 uc008osf.4 Involved in early stages of melanosome biogenesis and maturation. Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS6. Cytoplasm Cytoplasm, cytosol Found in heart, brain, spleen, liver, lung, kidney and testis. Note=Defects in Hps3 are the cause of the cocoa (coa) mutant, which is characterized by hypopigmentation and platelet dysfunction (PubMed:11707070). cytoplasm cytosol organelle organization BLOC-2 complex pigmentation uc008osf.1 uc008osf.2 uc008osf.3 uc008osf.4 
ENSMUST00000012587.4 Kif11 ENSMUST00000012587.4 kinesin family member 11 (from RefSeq NM_010615.2) ENSMUST00000012587.1 ENSMUST00000012587.2 ENSMUST00000012587.3 KIF11_MOUSE NM_010615 Q6P9P6 Q9Z1J0 uc008hin.1 uc008hin.2 Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface. Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts with RARRES1 and AGBL2 (By similarity). Cytoplasm Cytoplasm, cytoskeleton, spindle pole Phosphorylated exclusively on serine during S phase, but on both serine and Thr-925 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily. nucleotide binding spindle pole microtubule motor activity ATP binding nucleus cytoplasm spindle cytosol cytoskeleton kinesin complex microtubule spindle microtubule microtubule-based movement cell cycle spindle organization mitotic centrosome separation microtubule binding ATP-dependent microtubule motor activity, plus-end-directed ATPase activity protein kinase binding macromolecular complex regulation of mitotic centrosome separation spindle assembly cell division mitotic spindle mitotic spindle assembly uc008hin.1 uc008hin.2 
ENSMUST00000012627.5 Rpa3 ENSMUST00000012627.5 replication protein A3 (from RefSeq NM_026632.4) ENSMUST00000012627.1 ENSMUST00000012627.2 ENSMUST00000012627.3 ENSMUST00000012627.4 NM_026632 Q9CQ71 RFA3_MOUSE uc009axl.1 uc009axl.2 uc009axl.3 uc009axl.4 As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER), probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA. Component of the canonical replication protein A complex (RPA), a heterotrimer composed of RPA1, RPA2 and RPA3. Also a component of the aRPA, the alternative replication protein A complex, a trimeric complex similar to the replication protein A complex/RPA but where RPA1 and RPA3 are associated with RPA4 instead of RPA2 (By similarity). Nucleus Ubiquitinated by RFWD3 at stalled replication forks in response to DNA damage: ubiquitination by RFWD3 does not lead to degradation by the proteasome and promotes removal of the RPA complex from stalled replication forks, promoting homologous recombination. Belongs to the replication factor A protein 3 family. double-strand break repair via homologous recombination DNA binding damaged DNA binding single-stranded DNA binding nucleus nucleoplasm DNA replication factor A complex DNA replication DNA repair base-excision repair nucleotide-excision repair mismatch repair DNA recombination cellular response to DNA damage stimulus regulation of mitotic cell cycle site of double-strand break regulation of cell proliferation uc009axl.1 uc009axl.2 uc009axl.3 uc009axl.4 
ENSMUST00000012664.11 Phox2b ENSMUST00000012664.11 paired-like homeobox 2b (from RefSeq NM_008888.4) ENSMUST00000012664.1 ENSMUST00000012664.10 ENSMUST00000012664.2 ENSMUST00000012664.3 ENSMUST00000012664.4 ENSMUST00000012664.5 ENSMUST00000012664.6 ENSMUST00000012664.7 ENSMUST00000012664.8 ENSMUST00000012664.9 NM_008888 O35690 PHX2B_MOUSE Pmx2b uc008xpm.1 uc008xpm.2 uc008xpm.3 Interacts with TRIM11. Nucleus Belongs to the paired homeobox family. nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding neuron migration regulation of respiratory gaseous exchange by neurological system process noradrenergic neuron differentiation noradrenergic neuron development brainstem development DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development nervous system development negative regulation of cell proliferation glial cell differentiation regulation of gene expression cell differentiation in hindbrain medullary reticular formation development hindbrain tangential cell migration neuron differentiation skeletal muscle cell differentiation sequence-specific DNA binding negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter cell development autonomic nervous system development enteric nervous system development sympathetic nervous system development parasympathetic nervous system development inner ear development efferent axon development in a lateral line nerve respiratory system development retrotrapezoid nucleus neuron differentiation sympathetic ganglion development dopaminergic neuron differentiation cellular response to BMP stimulus neural crest cell migration involved in autonomic nervous system development uc008xpm.1 uc008xpm.2 uc008xpm.3 
ENSMUST00000012679.15 Tnpo3 ENSMUST00000012679.15 transportin 3, transcript variant 1 (from RefSeq NM_177296.5) ENSMUST00000012679.1 ENSMUST00000012679.10 ENSMUST00000012679.11 ENSMUST00000012679.12 ENSMUST00000012679.13 ENSMUST00000012679.14 ENSMUST00000012679.2 ENSMUST00000012679.3 ENSMUST00000012679.4 ENSMUST00000012679.5 ENSMUST00000012679.6 ENSMUST00000012679.7 ENSMUST00000012679.8 ENSMUST00000012679.9 NM_177296 Q6P2B1 Q7TSL6 Q8BKX4 Q8BP42 TNPO3_MOUSE Tnpo3 uc009bdy.1 uc009bdy.2 uc009bdy.3 Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus. Interacts with (GTP-bound) Ran. Interacts with (phosphorylated) SFRS1 and SFRS2; leading to their nuclear import. Interacts with NUP62. Interacts with RBM4. Interacts with CPSF6, promoting its nuclear import. Nucleus envelope Cytoplasm Note=Localizes to the nuclear envelope and annulate lamellae, which consists in stacks of endoplasmic reticulum membranes containing a high density of nuclear pores. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P2B1-1; Sequence=Displayed; Name=2; IsoId=Q6P2B1-2; Sequence=VSP_011179; Name=3; IsoId=Q6P2B1-3; Sequence=VSP_019595, VSP_019596; nucleus cytoplasm protein import into nucleus protein transport identical protein binding intracellular membrane-bounded organelle uc009bdy.1 uc009bdy.2 uc009bdy.3 
ENSMUST00000012798.14 Siglecf ENSMUST00000012798.14 sialic acid binding Ig-like lectin F, transcript variant 1 (from RefSeq NM_145581.2) ENSMUST00000012798.1 ENSMUST00000012798.10 ENSMUST00000012798.11 ENSMUST00000012798.12 ENSMUST00000012798.13 ENSMUST00000012798.2 ENSMUST00000012798.3 ENSMUST00000012798.4 ENSMUST00000012798.5 ENSMUST00000012798.6 ENSMUST00000012798.7 ENSMUST00000012798.8 ENSMUST00000012798.9 NM_145581 Q920G3 SIGL5_MOUSE Siglec5 uc009gmm.1 uc009gmm.2 uc009gmm.3 Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Membrane; Single-pass type I membrane protein. Predominantly expressed by immature monocytic/myeloid lineage cells in bone marrow. Also found at lower levels in mature neutrophils and monocytes. Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Name=Functional Glycomics Gateway - Glycan Binding; Note=Siglec-F; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Itlect_198"; lysosome cell adhesion membrane integral component of membrane regulation of endocytosis carbohydrate binding sialic acid binding monosaccharide binding uc009gmm.1 uc009gmm.2 uc009gmm.3 
ENSMUST00000012847.3 Cd209a ENSMUST00000012847.3 CD209a antigen (from RefSeq NM_133238.5) C209A_MOUSE Cire ENSMUST00000012847.1 ENSMUST00000012847.2 NM_133238 Q3TAT9 Q91ZW5 Q91ZX1 uc009ksq.1 uc009ksq.2 uc009ksq.3 uc009ksq.4 Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91ZX1-1; Sequence=Displayed; Name=2; Synonyms=neck-less; IsoId=Q91ZX1-2; Sequence=VSP_010067; Predominantly expressed in dendritic cells. Detected at very low levels in lung, spleen, lymph nodes and bone marrow. Down-regulated upon activation of dendritic cells. In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified. Mouse CD209A product was named DC-SIGN by PubMed:11581173 because of its similar expression pattern and chromosomal location in juxtaposition to CD23, but despite of the low sequence similarity. Name=Functional Glycomics Gateway - Glycan Binding; Note=SIGNR5; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_00130"; virus receptor activity mannose binding endocytosis cell surface membrane integral component of membrane carbohydrate binding regulation of T cell proliferation viral entry into host cell metal ion binding calcium-dependent protein binding carbohydrate derivative binding uc009ksq.1 uc009ksq.2 uc009ksq.3 uc009ksq.4 
ENSMUST00000012849.15 Retn ENSMUST00000012849.15 resistin, transcript variant 2 (from RefSeq NM_001204959.1) ENSMUST00000012849.1 ENSMUST00000012849.10 ENSMUST00000012849.11 ENSMUST00000012849.12 ENSMUST00000012849.13 ENSMUST00000012849.14 ENSMUST00000012849.2 ENSMUST00000012849.3 ENSMUST00000012849.4 ENSMUST00000012849.5 ENSMUST00000012849.6 ENSMUST00000012849.7 ENSMUST00000012849.8 ENSMUST00000012849.9 Fizz3 NM_001204959 Q99P87 RETN_MOUSE uc009ksh.1 uc009ksh.2 uc009ksh.3 uc009ksh.4 Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes. Homodimer; disulfide-linked. Secreted Expressed in white but not brown adipose tissue in a variety of organs. Belongs to the resistin/FIZZ family. hormone activity extracellular region extracellular space nucleus signal transduction positive regulation of collagen metabolic process positive regulation of smooth muscle cell migration response to insulin fat cell differentiation positive regulation of smooth muscle cell proliferation positive regulation of synaptic transmission negative regulation of feeding behavior positive regulation of progesterone secretion uc009ksh.1 uc009ksh.2 uc009ksh.3 uc009ksh.4 
ENSMUST00000012873.16 Zfp729b ENSMUST00000012873.16 zinc finger protein 729b, transcript variant 1 (from RefSeq NM_001163246.3) AA987161 ENSMUST00000012873.1 ENSMUST00000012873.10 ENSMUST00000012873.11 ENSMUST00000012873.12 ENSMUST00000012873.13 ENSMUST00000012873.14 ENSMUST00000012873.15 ENSMUST00000012873.2 ENSMUST00000012873.3 ENSMUST00000012873.4 ENSMUST00000012873.5 ENSMUST00000012873.6 ENSMUST00000012873.7 ENSMUST00000012873.8 ENSMUST00000012873.9 NM_001163246 Q80VN4 Q80VN4_MOUSE Zfp729b uc007rbf.1 uc007rbf.2 uc007rbf.3 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc007rbf.1 uc007rbf.2 uc007rbf.3 
ENSMUST00000013220.8 Amotl1 ENSMUST00000013220.8 angiomotin-like 1 (from RefSeq NM_001081395.1) AMOL1_MOUSE B9EKN5 ENSMUST00000013220.1 ENSMUST00000013220.2 ENSMUST00000013220.3 ENSMUST00000013220.4 ENSMUST00000013220.5 ENSMUST00000013220.6 ENSMUST00000013220.7 NM_001081395 Q571F1 Q9D4H4 uc009oep.1 uc009oep.2 uc009oep.3 uc009oep.4 Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Cell junction, tight junction Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D4H4-1; Sequence=Displayed; Name=2; IsoId=Q9D4H4-2; Sequence=VSP_044080; Expressed in exocrine glands, including pancreas, submandibular gland, lacrimal gland, parotid gland and sublingual gland (at protein level). Polyubiquitinated by NEDD4, leading to proteasomal degradation. Belongs to the angiomotin family. angiogenesis establishment of cell polarity involved in ameboidal cell migration protein binding bicellular tight junction COP9 signalosome Wnt signaling pathway apical plasma membrane lamellipodium actin cytoskeleton organization cell junction regulation of cell migration cytoplasmic vesicle hippo signaling identical protein binding positive regulation of blood vessel endothelial cell migration uc009oep.1 uc009oep.2 uc009oep.3 uc009oep.4 
ENSMUST00000013235.6 Tmem190 ENSMUST00000013235.6 transmembrane protein 190 (from RefSeq NM_030028.1) ENSMUST00000013235.1 ENSMUST00000013235.2 ENSMUST00000013235.3 ENSMUST00000013235.4 ENSMUST00000013235.5 NM_030028 Q9D2E9 TM190_MOUSE uc009eyp.1 uc009eyp.2 uc009eyp.3 uc009eyp.4 uc009eyp.5 Membrane ; Single- pass type I membrane protein Note=Localizes in the intracellular space in testicular germ cells and sperm. Detected also on the cell surface in post-meiotic round spermatids. In cauda epididymal sperm relocates during the acrosome reaction from the inner-acrosomal membrane onto the equatorial segment surface, on which sperm-oocyte fusion occurs. Colocalizes with IZUMO1 at the inner-acrosomal membrane. Detected in testis and in a mixture of spermatogenic cells at various stages (testicular germ cells). Not detected in heart, brain, spleen, lung, liver, skeletal muscle and kidney. Mice are normal with no alterations in fertility, body size and behavior. inner acrosomal membrane hematopoietic progenitor cell differentiation membrane integral component of membrane protein self-association uc009eyp.1 uc009eyp.2 uc009eyp.3 uc009eyp.4 uc009eyp.5 
ENSMUST00000013262.15 Zkscan17 ENSMUST00000013262.15 zinc finger with KRAB and SCAN domains 17, transcript variant 1 (from RefSeq NM_172941.4) ENSMUST00000013262.1 ENSMUST00000013262.10 ENSMUST00000013262.11 ENSMUST00000013262.12 ENSMUST00000013262.13 ENSMUST00000013262.14 ENSMUST00000013262.2 ENSMUST00000013262.3 ENSMUST00000013262.4 ENSMUST00000013262.5 ENSMUST00000013262.6 ENSMUST00000013262.7 ENSMUST00000013262.8 ENSMUST00000013262.9 NM_172941 Nizp11 Q3TC40 Q3UTL1 Q5SXI5 Q8BKK0 Q8CGF9 ZN496_MOUSE Zfp496 Znf496 uc007jeb.1 uc007jeb.2 uc007jeb.3 uc007jeb.4 uc007jeb.5 DNA-binding transcription factor that can both act as an activator and a repressor. Interacts (via zinc-fingers) with JARID2. Interacts with NSD1. Q5SXI5; Q62315: Jarid2; NbExp=6; IntAct=EBI-7417351, EBI-493592; Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5SXI5-1; Sequence=Displayed; Name=2; IsoId=Q5SXI5-2; Sequence=VSP_038769; Name=3; IsoId=Q5SXI5-3; Sequence=VSP_038768; The C2H2-type zinc finger 1, also named C2HR, mediates the interaction with NSD1. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated nuclear body protein self-association positive regulation of transcription, DNA-templated metal ion binding uc007jeb.1 uc007jeb.2 uc007jeb.3 uc007jeb.4 uc007jeb.5 
ENSMUST00000013294.16 Gfod2 ENSMUST00000013294.16 glucose-fructose oxidoreductase domain containing 2, transcript variant 2 (from RefSeq NM_027469.5) ENSMUST00000013294.1 ENSMUST00000013294.10 ENSMUST00000013294.11 ENSMUST00000013294.12 ENSMUST00000013294.13 ENSMUST00000013294.14 ENSMUST00000013294.15 ENSMUST00000013294.2 ENSMUST00000013294.3 ENSMUST00000013294.4 ENSMUST00000013294.5 ENSMUST00000013294.6 ENSMUST00000013294.7 ENSMUST00000013294.8 ENSMUST00000013294.9 GFOD2_MOUSE NM_027469 Q9CYH5 uc009neb.1 uc009neb.2 uc009neb.3 Promotes matrix assembly. Secreted, extracellular space, extracellular matrix Belongs to the Gfo/Idh/MocA family. extracellular region oxidoreductase activity extracellular matrix organization extracellular matrix oxidation-reduction process uc009neb.1 uc009neb.2 uc009neb.3 
ENSMUST00000013299.11 Enkd1 ENSMUST00000013299.11 enkurin domain containing 1 (from RefSeq NM_198299.2) ENKD1_MOUSE ENSMUST00000013299.1 ENSMUST00000013299.10 ENSMUST00000013299.2 ENSMUST00000013299.3 ENSMUST00000013299.4 ENSMUST00000013299.5 ENSMUST00000013299.6 ENSMUST00000013299.7 ENSMUST00000013299.8 ENSMUST00000013299.9 NM_198299 Q7TSV9 uc292cwk.1 uc292cwk.2 Microtubule-binding protein which regulates microtubule organization and stability (By similarity). Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle (By similarity). This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (PubMed:35197565). Required for the assembly of both primary and motile cilia (PubMed:35301795, PubMed:35072334). Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (PubMed:35301795). Interacts with alpha-tubulin (By similarity). Interacts (via central region) with CCP110 (via N-terminal region); competes with CEP97 for binding to CCP110 (PubMed:35301795). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body Cell projection, cilium Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, cilium axoneme Note=Localized at the centrosome and accumulates at the parental centrioles during centriole duplication in cycling cells (By similarity). In ciliated cells, detected at the basal body of the cilium (By similarity). Localizes to the centrosome during interphase, to the primary cilium at G0, to the spindle poles during mitosis and to the centrosomes and central spindle during telophase and cytokinesis (By similarity). Widely expressed with highest levels in testis and lung. Severely impaired epidermal barrier function with a significant reduction in the thickness of the granular and spinous layers of the epidermis (PubMed:35197565). Misoriented division of basal keratinocytes and significantly reduced proliferation rate of basal keratinocytes and suprabasal cells (PubMed:35197565). Ciliogenesis defects in multiple organs (PubMed:35301795). Retinal photoreceptor cilia numbers are greatly decreased, leading to defective vision, and there is also a decreased number of renal primary cilia as well as a reduced percentage of ciliated cells in the tracheal epithelium (PubMed:35301795). Impaired cardiac function (PubMed:35301795). Males are fertile but a significant proportion of spermatozoa are aberrant with no tails (PubMed:35301795). molecular_function cytoplasmic microtubule biological_process microtubule cytoskeleton uc292cwk.1 uc292cwk.2 
ENSMUST00000013304.8 Atp6v0d1 ENSMUST00000013304.8 ATPase, H+ transporting, lysosomal V0 subunit D1 (from RefSeq NM_013477.4) Atp6d Atp6v0d1 ENSMUST00000013304.1 ENSMUST00000013304.2 ENSMUST00000013304.3 ENSMUST00000013304.4 ENSMUST00000013304.5 ENSMUST00000013304.6 ENSMUST00000013304.7 NM_013477 P51863 Q54A57 Q9QWJ2 VA0D1_MOUSE uc009ndg.1 uc009ndg.2 uc009ndg.3 Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:12963731). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (PubMed:12963731). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with ATP6AP2; ATP6AP2 is a V-ATPase accessory protein and the interaction promotes v-ATPase complex assembly (By similarity). Interacts with TMEM9; TMEM9 is a v-ATPase assembly regulator and the interaction induces the interaction with ATP6AP2 (By similarity). Interacts with PIP4P1 (PubMed:29644770). Membrane ; Peripheral membrane protein ; Cytoplasmic side Lysosome membrane ; Peripheral membrane protein Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein Note=Localizes to centrosome and the base of the cilium. Ubiquitous. Expressed throughout early development. Belongs to the V-ATPase V0D/AC39 subunit family. protein binding lysosomal membrane early endosome centrosome ion transport cellular iron ion homeostasis vacuolar transport vacuolar acidification brain development synaptic vesicle hydrogen-exporting ATPase activity, phosphorylative mechanism hydrogen ion transmembrane transporter activity membrane apical plasma membrane vacuolar proton-transporting V-type ATPase complex cell projection organization macromolecular complex proton-transporting V-type ATPase, V0 domain plasma membrane proton-transporting V-type ATPase complex cellular response to increased oxygen levels neuron projection axon terminus macromolecular complex binding proton-transporting ATPase activity, rotational mechanism cilium assembly hydrogen ion transmembrane transport uc009ndg.1 uc009ndg.2 uc009ndg.3 
ENSMUST00000013338.14 Arih2 ENSMUST00000013338.14 ariadne RBR E3 ubiquitin protein ligase 2, transcript variant 5 (from RefSeq NR_151664.2) ARI2_MOUSE Ari2 ENSMUST00000013338.1 ENSMUST00000013338.10 ENSMUST00000013338.11 ENSMUST00000013338.12 ENSMUST00000013338.13 ENSMUST00000013338.2 ENSMUST00000013338.3 ENSMUST00000013338.4 ENSMUST00000013338.5 ENSMUST00000013338.6 ENSMUST00000013338.7 ENSMUST00000013338.8 ENSMUST00000013338.9 NR_151664 Q9Z1K6 Triad1 Uip48 uc009rqo.1 uc009rqo.2 uc009rqo.3 E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (By similarity). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin- protein ligase activity is activated upon binding to neddylated form of the ECS complex. Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis (By similarity). Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence=; Autoinhibited by the ariadne domain, which masks the second RING-type zinc finger that contains the active site and inhibits the E3 activity (By similarity). Inhibition is relieved upon binding to neddylated cullin-RING ubiquitin ligase complexes, which activate the E3 ligase activity of ARIH1 (By similarity). Protein modification; protein ubiquitination. Interacts (via RING-type zinc finger 1) with UBE2L3. Interacts (via RING-type zinc finger 2) with UBE2N. Interacts with neddylated CUL5. Interacts (via RING-type 2) with GFI1B. Interacts with GFI1; prevents its ubiquitination and proteasomal degradation. Interacts with DCUN1D1 (via UBA-like domain); promotes DCUN1D1 ubiquitination (By similarity). Q9Z1K6; Q60778: Nfkbib; NbExp=2; IntAct=EBI-6861719, EBI-644469; Nucleus Cytoplasm Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT- type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate. The Ariadne domain inhibits activity by masking the second RING-type zinc finger that contains the active site. Ubiquitinated. Ubiquitination promotes proteasomal degradation. Belongs to the RBR family. Ariadne subfamily. ubiquitin ligase complex protein polyubiquitination ubiquitin-protein transferase activity protein binding nucleus nucleoplasm cytoplasm ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity Cul5-RING ubiquitin ligase complex ubiquitin conjugating enzyme binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process metal ion binding developmental cell growth ubiquitin protein ligase activity protein K63-linked ubiquitination protein K48-linked ubiquitination hematopoietic stem cell proliferation uc009rqo.1 uc009rqo.2 uc009rqo.3 
ENSMUST00000013458.9 Adh4 ENSMUST00000013458.9 alcohol dehydrogenase 4 (class II), pi polypeptide (from RefSeq NM_011996.2) ADH4_MOUSE Adh2 Adh4 ENSMUST00000013458.1 ENSMUST00000013458.2 ENSMUST00000013458.3 ENSMUST00000013458.4 ENSMUST00000013458.5 ENSMUST00000013458.6 ENSMUST00000013458.7 ENSMUST00000013458.8 NM_011996 Q3V0P5 Q9QYY9 uc008rnj.1 uc008rnj.2 uc008rnj.3 Catalyzes the NAD-dependent oxidation of either all-trans- retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (By similarity). Reaction=all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH; Xref=Rhea:RHEA:21284, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.105; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21285; Evidence=; Reaction=9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH; Xref=Rhea:RHEA:42052, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78272, ChEBI:CHEBI:78273; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42053; Evidence=; Reaction=20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20- oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:39799, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76624, ChEBI:CHEBI:76645; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39800; Evidence=; Reaction=20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH; Xref=Rhea:RHEA:39803, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76645, ChEBI:CHEBI:76647; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39804; Evidence=; Reaction=1,4-benzoquinone + H(+) + NADH = hydroquinone + NAD(+); Xref=Rhea:RHEA:60660, ChEBI:CHEBI:15378, ChEBI:CHEBI:16509, ChEBI:CHEBI:17594, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60661; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.; Oxidation of 20-HETE is inhibited by low concentrations of N-heptylformamide (PubMed:16081420). Oxidation of 20- HETE is a decreased by 55-65% by either all-trans-retinol or all-trans- retinoic acid (PubMed:16081420). Strongly inhibited by omega-hydroxy fatty acids (PubMed:10514444). Kinetic parameters: KM=35 uM for 20-HETE ; KM=0.24 mM for 1,4-benzoquinone ; Dimer. Cytoplasm Liver specific. Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily. Has a much lower NAD-retinol dehydrogenase activity compared to the human ortholog. retinoid metabolic process NADPH:quinone reductase activity alcohol dehydrogenase (NAD) activity alcohol dehydrogenase activity, zinc-dependent alditol:NADP+ 1-oxidoreductase activity retinol dehydrogenase activity all-trans retinal binding nucleus cytoplasm cytosol alcohol metabolic process ethanol metabolic process ethanol oxidation cellular aldehyde metabolic process zinc ion binding fatty acid omega-oxidation oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor benzaldehyde dehydrogenase activity retinol binding ethanol binding retinol metabolic process alcohol catabolic process formaldehyde catabolic process metal ion binding NAD binding S-(hydroxymethyl)glutathione dehydrogenase activity oxidation-reduction process quinone metabolic process uc008rnj.1 uc008rnj.2 uc008rnj.3 
ENSMUST00000013497.8 Siglecl2 ENSMUST00000013497.8 RIKEN cDNA 4931406B18 gene (from RefSeq NM_028737.3) 4931406B18Rik A2RSL7 A2RSL7_MOUSE ENSMUST00000013497.1 ENSMUST00000013497.2 ENSMUST00000013497.3 ENSMUST00000013497.4 ENSMUST00000013497.5 ENSMUST00000013497.6 ENSMUST00000013497.7 NM_028737 uc009gmw.1 uc009gmw.2 molecular_function cellular_component biological_process membrane integral component of membrane uc009gmw.1 uc009gmw.2 
ENSMUST00000013559.3 Igf2bp1 ENSMUST00000013559.3 insulin-like growth factor 2 mRNA binding protein 1, transcript variant 1 (from RefSeq NM_009951.4) ENSMUST00000013559.1 ENSMUST00000013559.2 IF2B1_MOUSE NM_009951 O88477 Q80US9 Q8BRH1 Vickz1 uc007lay.1 uc007lay.2 uc007lay.3 uc007lay.4 uc007lay.5 RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6- methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells (By similarity). Binds to the oncofetal H19 transcript and regulates its localization (By similarity). Binds to and stabilizes BTRC/FBW1A mRNA (By similarity). Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2 (By similarity). During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts (By similarity). Interacts with GAP43 transcript and transports it to axons. Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binding to MYC mRNA is enhanced by m6A- modification of the CRD (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA. Binds to the neuron-specific TAU mRNA and regulates its localization. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons. During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing. Can form homodimers and heterodimers with IGF2BP1 and IGF2BP3 (By similarity). Component of the coding region determinant (CRD)- mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1 (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1 (By similarity). Associates with mRNP complex (By similarity). Interacts with FMR1 (By similarity). Component of a multisubunit autoregulatory RNP complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with AGO1 and AGO2 (By similarity). Interacts, through domains KH3 and KH4, with PABPC1 in an RNA-independent manner (By similarity). Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP. Interacts with ELAVL4 in an RNA-dependent manner. Associates with microtubules and polysomes. Interacts with ELAVL1 and MATR3 (By similarity). Nucleus. Cytoplasm. Cytoplasm, perinuclear region Cytoplasm, P-body Cytoplasm, Stress granule Cell projection, lamellipodium Cell projection, dendrite Cell projection, dendritic spine Cell projection, growth cone Cell projection, filopodium Cell projection, axon Note=In the nucleus, located in discrete foci, coinciding with the sites of ACTB transcription (By similarity). In the cytoplasm, localizes in cytoplasmic mRNP granules. Colocalizes with microtubules in growth cone filopodia and along neurites in neuronal cells (By similarity). Cytoplasmic colocalization with ACTB mRNA is partially lost at the cell periphery, suggesting release of the transcript (By similarity). In hippocampal neurons, predominantly located within dendrites, particularly at dendritic branching points in young cells, compared to axons (By similarity). In axons, predominantly found in axonal branches and their growth cones (By similarity). In neuronal processes, exhibits fast retrograde and anterograde movements, when associated with ACTB mRNA; this motility is lost when the association is inhibited (By similarity). Dendritic levels are regulated by neuronal activity and glutaminergic signals: they are increased by KCl-induced depolarization, which induces rapid efflux from the cell body into dendrites, and decreased by NMDA receptor agonists (By similarity). In motile cells, such as migrating fibroblasts, localizes to leading edges where it colocalizes with microtubules and microfilaments and to retracting tails (By similarity). In motile cells, transported towards the leading edge into the cortical region of the lamellipodia where it is connected to microfilaments (By similarity). In response to cellular stress, such as oxidative stress or heat shock, recruited to stress granules, but not to processing bodies (By similarity). Expressed in zygotes and blastocysts (at protein level). Expressed in brain, skeletal muscle, trophoblasts of placenta, oocytes and spermatogonia (at protein level). Expressed in testis and ovary. Following colon injury, expressed in the wound bed mesenchyme during the first phase of repair, probably by colonic mesenchymal stem cells (at protein level). Expressed during embryonic development and expression declines towards birth (at protein level). At 10.5 dpc, mainly expressed in the fore- and hindbrain, the snout, the branchial arches, the developing limb buds, and the tail. At 12.5 dpc, expression increased in the expanding fore- and hindbrain, as well as in the neural tract. Marked expression also observed in the snout, the interdigital mesenchyme of the limb buds, the tail, the branchial arches and somites, and the developing eye, tongue, heart and liver. Expressed in myoblasts and myotubes at 12.5 dpc (at protein level). From 12.5 to 15.5 dpc, expressed at the basal plasma cell membrane in the basal layer of the epidermis of the skin, lung and intestine (at protein level). Expressed in gonads at 12.5 and 14.5 dpc (at protein level). At 14.5 dpc in limb buds, becomes restricted to the future tendons. Expressed in germ cells at 16.5 dpc (at protein level). At 17.5 dpc, expression generally decreases, but remains high in the intestine, in the developing tubules of the kidney, and in the liver. Expressed until P12, although very low levels may remain in some tissues, such as intestines, kidney and brain, throughout adulthood. Following colonic injury, up-regulated in the wound mucosa at days 2 and 4 post-injury and down-regulated at day 6 post-injury, as compared with uninjured mucosa. Domains KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules. KH3 and KH4 mediate association with the cytoskeleton. Two nuclear export signals (NES) have been identified in KH2 and KH4 domains, respectively. Only KH2 NES is XPO1-dependent. Both NES may be redundant, since individual in vitro mutations do not affect subcellular location of the full-length protein. Phosphorylated. Phosphorylation may impair association with ACTB mRNA and hence abolishes translational repression (By similarity). Mutant mice exhibit high perinatal mortality and only 50% are alive 3 days after birth. Early death may be due to intestinal dysfunction. Animals are on average 40% smaller than wild- type and heterozygous sex-matched littermates. Growth retardation, probably due to hypoplasia, appears from 17.5 dpc and remains permanent into adult life. Mutant animals exhibit other stricking features, including impaired development of the intestine, with small and misshapen villi and twisted colon crypts, abnormal kidney architecture and loss of cartilage in the lower extremities. Some animals show signs of neurological damage, including aggressive behavior, restlessness and circular movements. Belongs to the RRM IMP/VICKZ family. nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding nucleus nucleoplasm cytoplasm cytosol RNA localization regulation of translation cytoplasmic stress granule regulation of mRNA stability involved in response to stress negative regulation of translation pallium cell proliferation in forebrain lamellipodium filopodium axon dendrite growth cone cell projection dendritic spine translation regulator activity mRNA 5'-UTR binding perinuclear region of cytoplasm mRNA transport CRD-mediated mRNA stabilization CRD-mediated mRNA stability complex neuronal stem cell population maintenance ribonucleoprotein complex uc007lay.1 uc007lay.2 uc007lay.3 uc007lay.4 uc007lay.5 
ENSMUST00000013633.12 Fgfrl1 ENSMUST00000013633.12 fibroblast growth factor receptor-like 1, transcript variant 1 (from RefSeq NM_054071.3) ENSMUST00000013633.1 ENSMUST00000013633.10 ENSMUST00000013633.11 ENSMUST00000013633.2 ENSMUST00000013633.3 ENSMUST00000013633.4 ENSMUST00000013633.5 ENSMUST00000013633.6 ENSMUST00000013633.7 ENSMUST00000013633.8 ENSMUST00000013633.9 FGRL1_MOUSE Fgfr5 NM_054071 Q91V87 Q920C2 Q920C3 uc008ypa.1 uc008ypa.2 uc008ypa.3 uc008ypa.4 Has a negative effect on cell proliferation. Interacts with FGF2 with a low affinity. Cell membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=FGFR5beta, FGFR5b; IsoId=Q91V87-1; Sequence=Displayed; Name=2; Synonyms=FGFR5gamma, FGFR5g; IsoId=Q91V87-2; Sequence=VSP_013976; Highly expressed in the kidney, brain and lung. Weakly expressed in the muscle, thymus, lymph node, stomach, intestine, colon and liver. Expressed in fetal cartilaginous structures like the nasal cartilage, the ribs and the sternum as well as in the cartilaginous rudiments of developing bones such as the vertebrae and the pelvic bone. High expression is found in the muscles of the tongue and the diaphragm. First detected at embryonic day 7 and became clearly visible at day 11 and increased until day 17. skeletal system development non-tyrosine kinase fibroblast growth factor receptor activity heart valve morphogenesis fibroblast growth factor-activated receptor activity Golgi apparatus plasma membrane integral component of plasma membrane cell surface receptor signaling pathway heparin binding negative regulation of cell proliferation fibroblast growth factor receptor signaling pathway membrane integral component of membrane fibroblast growth factor binding transport vesicle negative regulation of fibroblast growth factor receptor signaling pathway cell-cell contact zone protein homooligomerization ventricular septum morphogenesis diaphragm development cell-cell adhesion via plasma-membrane adhesion molecules uc008ypa.1 uc008ypa.2 uc008ypa.3 uc008ypa.4 
ENSMUST00000013667.3 Bcas1 ENSMUST00000013667.3 brain enriched myelin associated protein 1, transcript variant 1 (from RefSeq NM_029815.2) A2AVX2 BCAS1_MOUSE ENSMUST00000013667.1 ENSMUST00000013667.2 NM_029815 Nabc1 Q80YN3 Q9CVA1 uc008oby.1 uc008oby.2 uc008oby.3 uc008oby.4 Required for myelination. Homodimer. Interacts with DYNLL1 and DYNLL2. Cytoplasm Highly expressed in the brain and, more specifically, in oligodendrocytes. Expressed in the Schwann cells (at protein level). Mice display hypomyelination, schizophrenia-like behavioral abnormalities and a tendency toward reduced anxiety-like behaviors and up-regulation of inflammatory genes in the brain. cytoplasm cytosol postsynaptic density myelination protein homodimerization activity uc008oby.1 uc008oby.2 uc008oby.3 uc008oby.4 
ENSMUST00000013693.11 Commd8 ENSMUST00000013693.11 COMM domain containing 8, transcript variant 1 (from RefSeq NM_178599.5) COMD8_MOUSE ENSMUST00000013693.1 ENSMUST00000013693.10 ENSMUST00000013693.2 ENSMUST00000013693.3 ENSMUST00000013693.4 ENSMUST00000013693.5 ENSMUST00000013693.6 ENSMUST00000013693.7 ENSMUST00000013693.8 ENSMUST00000013693.9 NM_178599 Q9CZG3 Q9D7F6 uc008xre.1 uc008xre.2 uc008xre.3 May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5. Cytoplasm Nucleus molecular_function nucleus nucleoplasm cytoplasm cytosol biological_process uc008xre.1 uc008xre.2 uc008xre.3 
ENSMUST00000013737.13 Ndufs2 ENSMUST00000013737.13 NADH:ubiquinone oxidoreductase core subunit S2, transcript variant 1 (from RefSeq NM_153064.6) ENSMUST00000013737.1 ENSMUST00000013737.10 ENSMUST00000013737.11 ENSMUST00000013737.12 ENSMUST00000013737.2 ENSMUST00000013737.3 ENSMUST00000013737.4 ENSMUST00000013737.5 ENSMUST00000013737.6 ENSMUST00000013737.7 ENSMUST00000013737.8 ENSMUST00000013737.9 NDUS2_MOUSE NM_153064 Q3TNA8 Q3U5Y9 Q3UJX7 Q91WD5 Q99L23 uc007dnm.1 uc007dnm.2 uc007dnm.3 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:26437605, PubMed:29887397, PubMed:31297047). Essential for the catalytic activity and assembly of complex I (PubMed:26437605, PubMed:29887397, PubMed:31297047). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (PubMed:30922174). Plays an important role in carotid body sensing of hypoxia (PubMed:26437605, PubMed:29887397). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (PubMed:31297047). Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence= Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster.; Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Component of the iron- sulfur (IP) fragment of the enzyme. Interacts with NDUFAF3. Interacts with NDUFAF7 (By similarity). Interacts with CERS2 (PubMed:32279995). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Dimethylation at Arg-118 by NDUFAF7 takes place after NDUFS2 assembles into the complex I, leading to stabilize the early intermediate complex. Knockout mice show early perinatal death and major defects in the CNS, compromising especially the postnatal development of dorsal cortex, corpus callosum, hippocampus and cerebellum (PubMed:31297047). Neonatal neurogenesis and gliogenesis are deeply impaired (PubMed:31297047). Belongs to the complex I 49 kDa subunit family. Sequence=AAH03898.1; Type=Erroneous initiation; Evidence=; NADH dehydrogenase activity nucleoplasm mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I response to oxidative stress NADH dehydrogenase (ubiquinone) activity membrane oxidoreductase activity oxidoreductase activity, acting on NAD(P)H ubiquitin protein ligase binding mitochondrial ATP synthesis coupled electron transport metal ion binding quinone binding NAD binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding oxidation-reduction process respiratory chain uc007dnm.1 uc007dnm.2 uc007dnm.3 
ENSMUST00000013755.12 Snx31 ENSMUST00000013755.12 sorting nexin 31, transcript variant 1 (from RefSeq NM_025712.5) ENSMUST00000013755.1 ENSMUST00000013755.10 ENSMUST00000013755.11 ENSMUST00000013755.2 ENSMUST00000013755.3 ENSMUST00000013755.4 ENSMUST00000013755.5 ENSMUST00000013755.6 ENSMUST00000013755.7 ENSMUST00000013755.8 ENSMUST00000013755.9 NM_025712 Q6P8Y7 Q8BH14 Q9D690 SNX31_MOUSE uc007vmv.1 uc007vmv.2 uc007vmv.3 May be involved in protein trafficking. Interacts with CCDC22, CCDC93, VPS26C and VPS35L, associates with the retriever and CCC complexes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P8Y7-1; Sequence=Displayed; Name=2; IsoId=Q6P8Y7-2; Sequence=VSP_033263; Belongs to the sorting nexin family. protein binding early endosome intracellular protein transport protein transport macromolecular complex phosphatidylinositol binding retrograde transport, endosome to plasma membrane uc007vmv.1 uc007vmv.2 uc007vmv.3 
ENSMUST00000013759.6 Fnbp4 ENSMUST00000013759.6 Fnbp4 (from geneSymbol) A0A0R4IZZ6 A0A0R4IZZ6_MOUSE ENSMUST00000013759.1 ENSMUST00000013759.2 ENSMUST00000013759.3 ENSMUST00000013759.4 ENSMUST00000013759.5 Fnbp4 U40750 uc008ktb.1 uc008ktb.2 uc008ktb.3 nuclear speck uc008ktb.1 uc008ktb.2 uc008ktb.3 
ENSMUST00000013771.15 Trim54 ENSMUST00000013771.15 tripartite motif-containing 54 (from RefSeq NM_021447.2) ENSMUST00000013771.1 ENSMUST00000013771.10 ENSMUST00000013771.11 ENSMUST00000013771.12 ENSMUST00000013771.13 ENSMUST00000013771.14 ENSMUST00000013771.2 ENSMUST00000013771.3 ENSMUST00000013771.4 ENSMUST00000013771.5 ENSMUST00000013771.6 ENSMUST00000013771.7 ENSMUST00000013771.8 ENSMUST00000013771.9 Murf NM_021447 Q9ERP3 Rnf30 TRI54_MOUSE uc008wxd.1 uc008wxd.2 uc008wxd.3 uc008wxd.4 May bind and stabilize microtubules during myotubes formation. Homooligomer and heterooligomer. Interacts with TRIM63 and probably with TRIM55 (By similarity). Interacts with tubulin. Q9ERP3; Q14192: FHL2; Xeno; NbExp=2; IntAct=EBI-15626796, EBI-701903; Q9ERP3; Q14315-1: FLNC; Xeno; NbExp=2; IntAct=EBI-15626796, EBI-15532913; Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles. Selectively expressed in heart and skeletal muscle (at protein level). Also detected in lung and brain at much lower level. At 8.5 dpc expressed in the developing cardiac region. At 10.5 dpc expression is restricted to the cardiac region and myotome of the somites. Pre-natal expression is muscle-specific. protein binding cytoplasm cytoskeleton microtubule microtubule associated complex negative regulation of microtubule depolymerization multicellular organism development microtubule binding zinc ion binding Z disc cell differentiation metal ion binding uc008wxd.1 uc008wxd.2 uc008wxd.3 uc008wxd.4 
ENSMUST00000013773.12 Cad ENSMUST00000013773.12 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, transcript variant 1 (from RefSeq NM_023525.3) B2RQC6 B7ZN27 ENSMUST00000013773.1 ENSMUST00000013773.10 ENSMUST00000013773.11 ENSMUST00000013773.2 ENSMUST00000013773.3 ENSMUST00000013773.4 ENSMUST00000013773.5 ENSMUST00000013773.6 ENSMUST00000013773.7 ENSMUST00000013773.8 ENSMUST00000013773.9 NM_023525 PYR1_MOUSE uc008wwz.1 uc008wwz.2 uc008wwz.3 Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. Reaction=2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate; Xref=Rhea:RHEA:18633, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228, ChEBI:CHEBI:58359, ChEBI:CHEBI:456216; EC=6.3.5.5; Evidence=; Reaction=H2O + L-glutamine = L-glutamate + NH4(+); Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2; Evidence=; Reaction=2 ATP + hydrogencarbonate + NH4(+) = 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate; Xref=Rhea:RHEA:18029, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=6.3.4.16; Evidence=; Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L- aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228; EC=2.1.3.2; Evidence=; Reaction=(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate; Xref=Rhea:RHEA:24296, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30864, ChEBI:CHEBI:32814; EC=3.5.2.3; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity). ; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 4 magnesium or manganese ions per subunit. ; Allosterically regulated and controlled by phosphorylation. 5-phosphoribose 1-diphosphate (PRPP) is an activator while UMP and UTP are inhibitors of the CPSase reaction (By similarity). Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. Homohexamer. Interacts with CIPC. Cytoplasm Nucleus Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B2RQC6-1; Sequence=Displayed; Name=2; IsoId=B2RQC6-2; Sequence=VSP_053912; Activated by MAP kinase (Erk1/2) phosphorylation just prior to the S phase of the cell cycle, when the demand for pyrimidine nucleotides is greatest, and down-regulated as the cells emerge from S phase by protein kinase A (PKA) phosphorylation. Phosphorylation at Ser-1859 by RPS6KB1 downstream of MTOR promotes oligomerization and stimulates dihydroorotase activity. Phosphorylation at Ser-1406 reduces sensitivity to feedback inhibition by UTP (By similarity). GATase (glutamine amidotransferase) and CPSase (carbamoyl phosphate synthase) form together the glutamine-dependent CPSase (GD-CPSase) (EC 6.3.5.5). In the N-terminal section; belongs to the CarA family. In the 2nd section; belongs to the CarB family. In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. nucleotide binding liver development UTP binding catalytic activity aspartate carbamoyltransferase activity carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity dihydroorotase activity protein kinase activity ATP binding nucleus nucleoplasm cytoplasm cytosol 'de novo' pyrimidine nucleobase biosynthetic process pyrimidine nucleotide biosynthetic process UTP biosynthetic process cellular amino acid metabolic process glutamine metabolic process nitrogen compound metabolic process heart development female pregnancy lactation metabolic process zinc ion binding response to amine nuclear matrix amino acid binding transferase activity carboxyl- or carbamoyltransferase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides ligase activity drug metabolic process peptidyl-threonine phosphorylation citrulline biosynthetic process enzyme binding response to caffeine animal organ regeneration response to insulin macromolecular complex response to testosterone cellular response to drug response to starvation identical protein binding cell projection neuronal cell body terminal bouton 'de novo' UMP biosynthetic process protein autophosphorylation metal ion binding response to cortisol cellular response to epidermal growth factor stimulus uc008wwz.1 uc008wwz.2 uc008wwz.3 
ENSMUST00000013797.3 1810065E05Rik ENSMUST00000013797.3 RIKEN cDNA 1810065E05 gene (from RefSeq NM_027239.2) 1810065E05Rik ENSMUST00000013797.1 ENSMUST00000013797.2 NM_027239 Q5NC41 Q5NC41_MOUSE uc007jbl.1 uc007jbl.2 uc007jbl.3 molecular_function cellular_component response to bacterium uc007jbl.1 uc007jbl.2 uc007jbl.3 
ENSMUST00000013807.8 Pten ENSMUST00000013807.8 phosphatase and tensin homolog (from RefSeq NM_008960.2) ENSMUST00000013807.1 ENSMUST00000013807.2 ENSMUST00000013807.3 ENSMUST00000013807.4 ENSMUST00000013807.5 ENSMUST00000013807.6 ENSMUST00000013807.7 Mmac1 NM_008960 O08586 PTEN_MOUSE Q3UFB0 Q542G1 uc008hfr.1 uc008hfr.2 uc008hfr.3 This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK076980.1, AK088717.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3. Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5- tetrakisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:10339565, PubMed:19778506, PubMed:31492966). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (By similarity). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (By similarity). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (By similarity). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (PubMed:10339565, PubMed:19778506). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + phosphate; Xref=Rhea:RHEA:25017, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57836, ChEBI:CHEBI:58456; EC=3.1.3.67; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25018; Evidence=; Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20630; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47005; Evidence=; Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10685; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + phosphate; Xref=Rhea:RHEA:43552, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:83416, ChEBI:CHEBI:83419; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43553; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol- 3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho- (1D-myo-inositol-4,5-bisphosphate) + phosphate; Xref=Rhea:RHEA:43560, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:83420, ChEBI:CHEBI:83423; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43561; Evidence=; Reaction=1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo- inositol 1,4,5,6-tetrakisphosphate + phosphate; Xref=Rhea:RHEA:77143, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57627, ChEBI:CHEBI:57733; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77144; Evidence=; Reaction=1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo- inositol 1,4,5-trisphosphate + phosphate; Xref=Rhea:RHEA:77155, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57895, ChEBI:CHEBI:203600; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77156; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Monomer. The unphosphorylated form interacts with the second PDZ domain of MAGI2 (By similarity). Interacts with MAGI2, MAGI3, MAST1 and MAST3, but neither with MAST4 nor with DLG5; interaction with MAGI2 increases protein stability (By similarity). Interacts with NEDD4 (By similarity). Interacts with NDFIP1 and NDFIP2; in the presence of NEDD4 or ITCH, this interaction promotes PTEN ubiquitination (By similarity). Interacts (via C2 domain) with FRK (By similarity). Interacts with USP7; the interaction is direct (By similarity). Interacts with ROCK1 (PubMed:20008297). Interacts with XIAP/BIRC4 (PubMed:19473982). Interacts with STK11; the interaction phosphorylates PTEN (By similarity). Interacts with PPP1R16B (By similarity). Interacts with NOP53; regulates PTEN phosphorylation and increases its stability (By similarity). Interacts (via PDZ domain-binding motif) with DLG4; the interaction is induced by NMDA and is required for PTEN location at postsynaptic density (By similarity). Interacts with the regulatory p85 subunit of the PI3K kinase complex and with Rho GTPase-activating protein DLC1; in resting cells, interacts (via C2 tensin-type domain) with p85 but, following growth factor stimulation, PTEN is phosphorylated which leads to weakened interaction with p85 and enhanced interaction (via C2 tensin-type domain) with DLC1 while p85 interaction with TNS3 increases (By similarity). O08586; P49452: Cenpc; NbExp=2; IntAct=EBI-1186266, EBI-1186252; O08586; Q9JHL1: Nherf2; NbExp=3; IntAct=EBI-1186266, EBI-538451; O08586; B1AZ99: Otud3; NbExp=2; IntAct=EBI-1186266, EBI-16170692; O08586; P02340: Tp53; NbExp=4; IntAct=EBI-1186266, EBI-474016; O08586; P62991: Ubc; NbExp=2; IntAct=EBI-1186266, EBI-413074; O08586; Q6A4J8: Usp7; NbExp=2; IntAct=EBI-1186266, EBI-1216254; Cytoplasm cleus cleus, PML body Cell projection, dendritic spine Postsynaptic density Note=Monoubiquitinated form is nuclear (By similarity). Nonubiquitinated form is cytoplasmic (By similarity). Colocalized with PML and USP7 in PML nuclear bodies (By similarity). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982). Associares with the postsynaptic density in response to NMDAR activation (By similarity). Expressed in brain (at protein level). Constitutively phosphorylated by CK2 under normal conditions. Phosphorylation results in an inhibited activity towards PIP3. Phosphorylation can both inhibit or promote PDZ-binding. Phosphorylation at Tyr-336 by FRK/PTK5 protects this protein from ubiquitin-mediated degradation probably by inhibiting its binding to NEDD4 (By similarity). Phosphorylation by PLK3 promotes its stability and prevents its degradation by the proteasome. Phosphorylation by ROCK1 is essential for its stability and activity. Phosphorylated on Thr-319 and Thr-321 in the C2-type tensin domain following EGF stimulation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 (By similarity). Monoubiquitinated; monoubiquitination is increased in presence of retinoic acid. Deubiquitinated by USP7; leading to its nuclear exclusion. Monoubiquitination of one of either Lys-13 and Lys-289 amino acid is sufficient to modulate PTEN compartmentalization (By similarity). Ubiquitinated by XIAP/BIRC4. Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation. ISGylated. ISGylation promotes PTEN degradation. Belongs to the PTEN phosphatase protein family. angiogenesis negative regulation of protein phosphorylation regulation of B cell apoptotic process phosphatidylinositol-3-phosphatase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity platelet-derived growth factor receptor binding protein binding nucleus nucleoplasm cytoplasm mitochondrion cytosol plasma membrane protein dephosphorylation lipid metabolic process apoptotic process neuron-neuron synaptic transmission nervous system development synapse assembly central nervous system development heart development aging response to nutrient learning or memory memory locomotory behavior protein tyrosine/serine/threonine phosphatase activity positive regulation of cell proliferation negative regulation of cell proliferation response to glucose cytoplasmic side of plasma membrane response to organic substance response to inorganic substance response to zinc ion positive regulation of gene expression positive regulation of cardiac muscle cell apoptotic process negative regulation of epithelial to mesenchymal transition regulation of neuron projection development negative regulation of neuron projection development anaphase-promoting complex binding response to organic cyclic compound response to activity dephosphorylation phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity apical plasma membrane cell migration PML body hydrolase activity enzyme binding protein kinase binding dentate gyrus development central nervous system neuron axonogenesis PDZ domain binding negative regulation of cell migration adult behavior neuron projection development negative regulation of myelination regulation of protein stability regulation of synaptic transmission, GABAergic central nervous system myelin maintenance response to estradiol regulation of cellular component size cellular response to insulin stimulus regulation of myeloid cell apoptotic process response to ATP multicellular organismal response to stress social behavior ionotropic glutamate receptor binding peptidyl-tyrosine dephosphorylation myelin sheath adaxonal region cellular response to decreased oxygen levels response to drug maternal behavior identical protein binding cell projection neuron projection positive regulation of apoptotic process negative regulation of apoptotic process dendritic spine Schmidt-Lanterman incisure protein kinase B signaling endothelial cell migration cellular response to leptin stimulus postsynaptic membrane response to ethanol locomotor rhythm positive regulation of neuron differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell size negative regulation of organ growth response to arsenic-containing substance inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation platelet-derived growth factor receptor signaling pathway regulation of axon regeneration negative regulation of axon regeneration cardiac muscle tissue development forebrain morphogenesis brain morphogenesis negative regulation of epithelial cell proliferation negative regulation of phagocytosis negative regulation of axonogenesis protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of keratinocyte migration inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity regulation of cell cycle phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity negative regulation of focal adhesion assembly negative regulation of protein kinase B signaling rhythmic synaptic transmission negative regulation of cardiac muscle cell proliferation canonical Wnt signaling pathway synapse maturation prepulse inhibition male mating behavior long-term synaptic potentiation long term synaptic depression regulation of cellular localization prostate gland growth dendritic spine morphogenesis negative regulation of dendritic spine morphogenesis negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to electrical stimulus cellular response to ethanol cellular response to hypoxia negative regulation of ribosome biogenesis negative regulation of cell aging negative regulation of excitatory postsynaptic potential presynaptic membrane assembly postsynaptic density assembly postsynaptic cytosol negative regulation of potassium ion transmembrane transporter activity negative regulation of wound healing, spreading of epidermal cells positive regulation of TRAIL-activated apoptotic signaling pathway positive regulation of ubiquitin protein ligase activity negative regulation of vascular smooth muscle cell proliferation cellular response to nerve growth factor stimulus cellular response to insulin-like growth factor stimulus ubiquitin-specific protease binding protein tyrosine kinase binding positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of G1/S transition of mitotic cell cycle negative regulation of receptor activity positive regulation of excitatory postsynaptic potential negative regulation of synaptic vesicle clustering positive regulation of apoptotic signaling pathway uc008hfr.1 uc008hfr.2 uc008hfr.3 
ENSMUST00000013842.12 Pea15a ENSMUST00000013842.12 proliferation and apoptosis adaptor protein 15A, transcript variant 2 (from RefSeq NM_011063.4) ENSMUST00000013842.1 ENSMUST00000013842.10 ENSMUST00000013842.11 ENSMUST00000013842.2 ENSMUST00000013842.3 ENSMUST00000013842.4 ENSMUST00000013842.5 ENSMUST00000013842.6 ENSMUST00000013842.7 ENSMUST00000013842.8 ENSMUST00000013842.9 NM_011063 PEA15_MOUSE Pea15 Q3U5N7 Q62048 uc007dpy.1 uc007dpy.2 uc007dpy.3 This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]. Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A- mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). Binds RPS6KA3, MAPK3 and MAPK1. Interacts with CASP8 and FADD (By similarity). Transient interaction with PLD1 and PLD2. Cytoplasm Note=Associated with microtubules. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q62048-1; Sequence=Displayed; Name=2; IsoId=Q62048-2; Sequence=VSP_007736, VSP_007737; Predominantly expressed in the brain. Low levels in some peripheral organs. Phosphorylated by protein kinase C and calcium-calmodulin- dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones. Increases PLD1 and PLD2 levels, possibly by stabilizing the protein. DNA damage checkpoint protein kinase C binding protein binding nucleus cytoplasm cytosol microtubule associated complex apoptotic process carbohydrate transport intracellular signal transduction regulation of apoptotic process response to morphine negative regulation of glucose import negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extrinsic apoptotic signaling pathway via death domain receptors uc007dpy.1 uc007dpy.2 uc007dpy.3 
ENSMUST00000013845.13 Timm23 ENSMUST00000013845.13 translocase of inner mitochondrial membrane 23 (from RefSeq NM_016897.3) ENSMUST00000013845.1 ENSMUST00000013845.10 ENSMUST00000013845.11 ENSMUST00000013845.12 ENSMUST00000013845.2 ENSMUST00000013845.3 ENSMUST00000013845.4 ENSMUST00000013845.5 ENSMUST00000013845.6 ENSMUST00000013845.7 ENSMUST00000013845.8 ENSMUST00000013845.9 NM_016897 Q9CXU4 Q9CXU4_MOUSE Timm23 uc007syn.1 uc007syn.2 uc007syn.3 uc007syn.4 Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15. Membrane ; Multi- pass membrane protein Mitochondrion inner membrane ulti-pass membrane protein Belongs to the Tim17/Tim22/Tim23 family. mitochondrion mitochondrial inner membrane mitochondrial inner membrane presequence translocase complex intracellular protein transport protein transport P-P-bond-hydrolysis-driven protein transmembrane transporter activity membrane integral component of membrane protein transmembrane transport uc007syn.1 uc007syn.2 uc007syn.3 uc007syn.4 
ENSMUST00000013851.4 Tnfaip8l2 ENSMUST00000013851.4 tumor necrosis factor, alpha-induced protein 8-like 2 (from RefSeq NM_027206.3) ENSMUST00000013851.1 ENSMUST00000013851.2 ENSMUST00000013851.3 NM_027206 Q9D8Y7 TP8L2_MOUSE uc008qif.1 uc008qif.2 Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll- like signaling pathway by determining the strength of LPS-induced signaling and gene expression (PubMed:18455983). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Inhibits also autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (PubMed:34524845). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (PubMed:34524845). May interact with CASP8; however, such result is unclear since could not reproduce the interaction with CASP8. Interacts with RAC1. Q9D8Y7; O89110: Casp8; NbExp=2; IntAct=EBI-1781612, EBI-851690; Cytoplasm Nucleus Lysosome Expressed in thymus, spleen, lymph node and small intestine, but not in liver, heart, muscle, testis, spinal cord or brain. Up-regulated in the spinal cord of mice with experimental autoimmune encephalomyelitis. Constitutively expressed by macrophages, B and T-lymphocytes at various developmental stages. By TNF in fibroblasts. The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding (By similarity). Phosphorylated by TAK1/MAP3K7; this phosphorylation triggers association with BTRC and subsequent ubiquitination and degradation. Ubiquitinated in a BTRC-depdent manner; leading to degradation mediated through the proteasome pathway. When infected with lymphocytic choriomeningitis virus (LCMV), TIPE2-deficient mice exhibit significantly enhanced CD4(+) and CD8(+) T-cell immune responses compared with WT mice (PubMed:18455983). TIPE2-deficient NK-cells exhibit enhanced activation, cytotoxicity, and IFN-gamma production upon stimulation and enhanced response to IL-15 for maturation (PubMed:34524845). Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily. immune system process protein binding cytoplasm regulation of apoptotic process innate immune response negative regulation of inflammatory response negative regulation of T cell activation uc008qif.1 uc008qif.2 
ENSMUST00000013886.9 Ppp1r12c ENSMUST00000013886.9 protein phosphatase 1, regulatory subunit 12C, transcript variant 1 (from RefSeq NM_029834.4) ENSMUST00000013886.1 ENSMUST00000013886.2 ENSMUST00000013886.3 ENSMUST00000013886.4 ENSMUST00000013886.5 ENSMUST00000013886.6 ENSMUST00000013886.7 ENSMUST00000013886.8 Mbs85 NM_029834 PP12C_MOUSE Ppp1r12c Q3UMT1 Q9CWD5 uc009exq.1 uc009exq.2 uc009exq.3 Regulates myosin phosphatase activity. PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP. Interacts with NOD2 (By similarity). Cytoplasm Cytoplasm, cytoskeleton, stress fiber Phosphorylation at Thr-560 is essential for its interaction with PPP1CB. enzyme inhibitor activity cytoplasm cytoskeleton signal transduction phosphatase regulator activity protein kinase binding negative regulation of catalytic activity regulation of catalytic activity uc009exq.1 uc009exq.2 uc009exq.3 
ENSMUST00000013910.5 Ly6g6e ENSMUST00000013910.5 lymphocyte antigen 6 family member G6E, transcript variant 1 (from RefSeq NM_027366.2) ENSMUST00000013910.1 ENSMUST00000013910.2 ENSMUST00000013910.3 ENSMUST00000013910.4 LY66E_MOUSE NM_027366 Q8K1T6 Q9D7E5 uc008cfp.1 uc008cfp.2 uc008cfp.3 Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro potentiates alpha-3:beta-4- containing nAChRs maximum response by increasing peak current and slowing down receptor desensitization; the activity is dependent on its cell surface localization. Interacts with CHRNA4. Cell surface Cell membrane Cell projection Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K1T6-1; Sequence=Displayed; Name=2; IsoId=Q8K1T6-2; Sequence=VSP_059015; O-glycosylated. Contains sialic acid residues. LY6G6E is a pseudogene in humans. desensitization of G-protein coupled receptor protein signaling pathway transmembrane receptor protein serine/threonine kinase activity plasma membrane transmembrane receptor protein serine/threonine kinase signaling pathway cell surface membrane acetylcholine receptor activator activity acetylcholine receptor binding cell projection acetylcholine receptor signaling pathway regulation of neurotransmitter receptor activity uc008cfp.1 uc008cfp.2 uc008cfp.3 
ENSMUST00000013931.12 Ehmt2 ENSMUST00000013931.12 euchromatic histone lysine N-methyltransferase 2, transcript variant 1 (from RefSeq NM_145830.3) A2CG75 Bat8 EHMT2_MOUSE ENSMUST00000013931.1 ENSMUST00000013931.10 ENSMUST00000013931.11 ENSMUST00000013931.2 ENSMUST00000013931.3 ENSMUST00000013931.4 ENSMUST00000013931.5 ENSMUST00000013931.6 ENSMUST00000013931.7 ENSMUST00000013931.8 ENSMUST00000013931.9 G9a NM_145830 Ng36 Q6PE08 Q8K4R6 Q8K4R7 Q9Z148 Q9Z149 uc008ced.1 uc008ced.2 uc008ced.3 uc008ced.4 uc008ced.5 uc008ced.6 Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. Recruited to the promoters of target genes through interaction with transcriptional repressor MSX1, leading to the inhibition of myoblast differentiation via transcriptional repression of differentiation factors (PubMed:22629437). Reaction=N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60284, Rhea:RHEA-COMP:15541, Rhea:RHEA- COMP:15542, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; Reaction=L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60280, Rhea:RHEA-COMP:15542, Rhea:RHEA-COMP:15546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.367; Evidence=; Heterodimer; heterodimerizes with EHMT1/GLP (PubMed:15774718, PubMed:16702210). Interacts with GFI1B and WIZ (PubMed:16702210). Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EHMT1, RING1, RNF2, MBLR, L3MBTL2 and YAF2 (By similarity). Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Interacts with UHRF1 (PubMed:19056828). Interacts with CDYL. Interacts with REST only in the presence of CDYL. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2 (By similarity). Interacts with PRDM9 and CDYL; interaction only takes place when PRDM9 is bound to hotspot DNA (PubMed:27932493). Interacts with SMYD5 (PubMed:28250819). Interacts with MSX1 (via homeobox domain) (PubMed:22629437). Q9Z148; O70237: Gfi1b; NbExp=2; IntAct=EBI-444966, EBI-4287943; Q9Z148; P09631: Hoxa9; NbExp=2; IntAct=EBI-444966, EBI-925334; Q9Z148-1; Q07279: Nfe2; NbExp=4; IntAct=EBI-444981, EBI-6554737; Q9Z148-2; O88508-1: Dnmt3a; NbExp=3; IntAct=EBI-15737169, EBI-15650457; Q9Z148-2; O88509: Dnmt3b; NbExp=3; IntAct=EBI-15737169, EBI-7987547; Nucleus Chromosome Note=Almost excluded form nucleoli. Associates with euchromatic regions (By similarity). Does not associate with heterochromatin (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=G9a-L; IsoId=Q9Z148-1; Sequence=Displayed; Name=2; Synonyms=G9a-S; IsoId=Q9Z148-2; Sequence=VSP_002214, VSP_002215, VSP_002216; Name=3; IsoId=Q9Z148-3; Sequence=VSP_002214, VSP_002215; Ubiquitous. Expressed in the developing limb bud at 11.5 dpc (at protein level). The ANK repeats bind H3K9me1 and H3K9me2. The SET domain mediates interaction with WIZ. In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster. Methylated at Lys-239; automethylated. Mice show a higher level of histone H3 with acetylated 'Lys-9' (H3K9ac) and/or methylated 'Lys-4' (H3K4me), display severe developmental defects and die within E9.5-E12.5 stages. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. NG36 and G9a were originally thought to derive from two separate genes. Sequence=AAC84164.1; Type=Erroneous gene model prediction; Evidence=; Sequence=AAC84165.1; Type=Erroneous gene model prediction; Evidence=; Sequence=AAH25539.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH58357.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding p53 binding protein binding nucleus nucleoplasm chromosome regulation of DNA replication DNA methylation chromatin organization regulation of transcription from RNA polymerase II promoter synaptonemal complex assembly germ cell development spermatid development long-term memory methyltransferase activity zinc ion binding cellular response to starvation fertilization DNA methylation on cytosine within a CG sequence protein-lysine N-methyltransferase activity histone methylation nuclear speck transferase activity histone-lysine N-methyltransferase activity peptidyl-lysine dimethylation response to nutrient levels methylation histone lysine methylation organ growth cellular response to drug phenotypic switching regulation of DNA methylation response to ethanol metal ion binding histone methyltransferase activity (H3-K9 specific) histone methyltransferase activity (H3-K27 specific) behavioral response to cocaine neuron fate specification histone H3-K9 methylation regulation of histone H3-K4 methylation regulation of histone H3-K9 methylation response to fungicide histone H3-K27 methylation C2H2 zinc finger domain binding cellular response to cocaine negative regulation of autophagosome assembly promoter-specific chromatin binding nucleolus uc008ced.1 uc008ced.2 uc008ced.3 uc008ced.4 uc008ced.5 uc008ced.6 
ENSMUST00000013949.15 Birc3 ENSMUST00000013949.15 baculoviral IAP repeat-containing 3 (from RefSeq NM_007464.3) A2CGA5 A2CGA5_MOUSE Birc3 ENSMUST00000013949.1 ENSMUST00000013949.10 ENSMUST00000013949.11 ENSMUST00000013949.12 ENSMUST00000013949.13 ENSMUST00000013949.14 ENSMUST00000013949.2 ENSMUST00000013949.3 ENSMUST00000013949.4 ENSMUST00000013949.5 ENSMUST00000013949.6 ENSMUST00000013949.7 ENSMUST00000013949.8 ENSMUST00000013949.9 NM_007464 uc009odb.1 uc009odb.2 uc009odb.3 uc009odb.4 uc009odb.5 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Nucleus Belongs to the IAP family. ubiquitin-protein transferase activity nucleus nucleoplasm cytoplasm cytosol spermatogenesis protein ubiquitination positive regulation of protein ubiquitination macromolecular complex regulation of apoptotic process membrane raft metal ion binding protein heterooligomerization regulation of necroptotic process uc009odb.1 uc009odb.2 uc009odb.3 uc009odb.4 uc009odb.5 
ENSMUST00000013966.8 Elof1 ENSMUST00000013966.8 ELF1 homolog, elongation factor 1, transcript variant 7 (from RefSeq NM_001357314.1) ENSMUST00000013966.1 ENSMUST00000013966.2 ENSMUST00000013966.3 ENSMUST00000013966.4 ENSMUST00000013966.5 ENSMUST00000013966.6 ENSMUST00000013966.7 Elof1 NM_001357314 Q545S6 Q545S6_MOUSE uc009onx.1 uc009onx.2 uc009onx.3 Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Nucleus Belongs to the ELOF1 family. translation elongation factor activity nucleus translational elongation metal ion binding uc009onx.1 uc009onx.2 uc009onx.3 
ENSMUST00000013970.9 Pip4k2c ENSMUST00000013970.9 phosphatidylinositol-5-phosphate 4-kinase, type II, gamma, transcript variant 1 (from RefSeq NM_054097.3) ENSMUST00000013970.1 ENSMUST00000013970.2 ENSMUST00000013970.3 ENSMUST00000013970.4 ENSMUST00000013970.5 ENSMUST00000013970.6 ENSMUST00000013970.7 ENSMUST00000013970.8 NM_054097 PI42C_MOUSE Pip4k2c Pip5k2c Q3UFU5 Q91XU3 Q99K02 uc007hiq.1 uc007hiq.2 uc007hiq.3 uc007hiq.4 Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin- dependent conversion to PtdIns(3,4,5)P3. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:12280, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57795, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.149; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12281; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5- phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:55992, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:83423, ChEBI:CHEBI:84968, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55993; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5- phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + GDP + H(+); Xref=Rhea:RHEA:55964, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:58189, ChEBI:CHEBI:83423, ChEBI:CHEBI:84968; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55965; Evidence=; Interacts with PIP5K1A; the interaction inhibits PIP5K1A kinase activity. Endoplasmic reticulum Cytoplasm No significant expression was discerned throughout the prenatal brains except for the olfactory mantle zone, which exhibited the expression signals weakly. On P0 and P7, the expression was weakly positive in the gray matter throughout the brain, with higher expression in the olfactory mitral cell layer. In the cerebellum, the expression was evenly positive in external and internal granule cell layers. On P21 and P56, the expression in non-cortical brain parenchyma was negligible. However, the expression was evident in the olfactory mitral cell layer, the piriform cortex, the hippocampal pyramidal CA1-3, and the cerebellar Purkinje cell layer, although much less distinct in the dentate granule cell layer and the cerebellar granule cell layer. In the cerebral cortex, the expression was weaker in layer V than the other layers. No significant expression was seen in the white matter. Phosphorylated, phosphorylation is induced by EGF. nucleotide binding ATP binding cytoplasm autophagosome endoplasmic reticulum regulation of autophagy membrane kinase activity phosphatidylinositol phosphate kinase activity 1-phosphatidylinositol-4-phosphate 5-kinase activity 1-phosphatidylinositol-5-phosphate 4-kinase activity phosphorylation transferase activity identical protein binding phosphatidylinositol metabolic process phosphatidylinositol phosphorylation positive regulation of autophagosome assembly uc007hiq.1 uc007hiq.2 uc007hiq.3 uc007hiq.4 
ENSMUST00000013995.13 Abca4 ENSMUST00000013995.13 ATP-binding cassette, sub-family A member 4 (from RefSeq NM_007378.1) ABCA4_MOUSE Abca4 Abcr ENSMUST00000013995.1 ENSMUST00000013995.10 ENSMUST00000013995.11 ENSMUST00000013995.12 ENSMUST00000013995.2 ENSMUST00000013995.3 ENSMUST00000013995.4 ENSMUST00000013995.5 ENSMUST00000013995.6 ENSMUST00000013995.7 ENSMUST00000013995.8 ENSMUST00000013995.9 NM_007378 O35600 uc008rel.1 uc008rel.2 uc008rel.3 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein was the first of the ABC transporters to be observed in photoreceptors and may play a role in the photoresponse. Mutations in the human gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and macular degeneration age-related 2. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC057853.1, AF000149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164136 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like the 11- cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where N-cis-retinylidene- phosphatidylethanolamine (N-cis-R-PE) is then isomerized to its all- trans isomer (N-trans-R-PE) and reduced by RDH8 to produce all-trans- retinol (all-trans-rol) and therefore prevents the accumulation of excess of 11-cis-retinal and its schiff-base conjugate and the formation of toxic bisretinoid (PubMed:10852960, PubMed:10412977, PubMed:22735453). Displays both ATPase and GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds (By similarity). Binds the unprotonated form of N- retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP and ATP binding and hydrolysis induce a protein conformational change that causes the dissociation of N-retinylidene- phosphatidylethanolamine (By similarity). Reaction=ATP + H2O + N-all-trans- retinylidenephosphatidylethanolamine(out) = ADP + H(+) + N-all-trans- retinylidenephosphatidylethanolamine(in) + phosphate; Xref=Rhea:RHEA:67188, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:167884, ChEBI:CHEBI:456216; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67189; Evidence=; Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:66132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:64612, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66133; Evidence=; Reaction=ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) = ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate; Xref=Rhea:RHEA:67192, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:167887, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67193; Evidence=; ATPase activity is decreased by cholesterol and ceramide. ATPase activity is stimulated by phosphatidylethanolamine. Phospholipids translocase activity is highly reduced by berylium fluoride and aluminum floride. N-ethylmaleimide inhibits phospholipid translocase activity. Membrane; Multi-pass membrane protein Endoplasmic reticulum Cell projection, cilium, photoreceptor outer segment Note=Localized to the rim and incisures of rod outer segments disks. Retinal-specific (PubMed:9202155). Seems to be exclusively found in the rims of rod photoreceptor cells. The second extracellular domain (ECD2, aa 1395-1680) undergoes conformational change in response to its specific interaction with its substrate all-trans-retinal. Nucleotide binding domain 1 (NBD1, aa 854- 1375) binds preferentially and with high affinity with the 11-cis retinal. N-glycosylated. Proteolytic cleavage by trypsin leads to a 120-kDa N-terminal fragment and a 115-kDa C-terminal fragment that are linked through disulfide bonds. Phosphorylation is independent of light exposure and modulates ATPase activity. Delayed dark adaptation but normal final rod threshold. Belongs to the ABC transporter superfamily. ABCA family. nucleotide binding photoreceptor outer segment lipid transporter activity ATP binding phospholipid transporter activity endoplasmic reticulum integral component of plasma membrane phospholipid transfer to membrane lipid transport visual perception membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances intracellular membrane-bounded organelle phospholipid translocation photoreceptor cell maintenance response to stimulus transmembrane transport phosphatidylethanolamine-translocating ATPase activity uc008rel.1 uc008rel.2 uc008rel.3 
ENSMUST00000014058.11 Klk10 ENSMUST00000014058.11 kallikrein related-peptidase 10 (from RefSeq NM_133712.2) ENSMUST00000014058.1 ENSMUST00000014058.10 ENSMUST00000014058.2 ENSMUST00000014058.3 ENSMUST00000014058.4 ENSMUST00000014058.5 ENSMUST00000014058.6 ENSMUST00000014058.7 ENSMUST00000014058.8 ENSMUST00000014058.9 Klk10 Klnj NES1 NM_133712 PRSSL1 Q99M20 Q99M20_MOUSE uc009gnq.1 uc009gnq.2 uc009gnq.3 serine-type endopeptidase activity proteolysis secretory granule uc009gnq.1 uc009gnq.2 uc009gnq.3 
ENSMUST00000014065.16 Clip3 ENSMUST00000014065.16 CAP-GLY domain containing linker protein 3, transcript variant 3 (from RefSeq NM_001360764.1) B9EHT4 CLIP3_MOUSE Clipr59 ENSMUST00000014065.1 ENSMUST00000014065.10 ENSMUST00000014065.11 ENSMUST00000014065.12 ENSMUST00000014065.13 ENSMUST00000014065.14 ENSMUST00000014065.15 ENSMUST00000014065.2 ENSMUST00000014065.3 ENSMUST00000014065.4 ENSMUST00000014065.5 ENSMUST00000014065.6 ENSMUST00000014065.7 ENSMUST00000014065.8 ENSMUST00000014065.9 NM_001360764 Q7TNI1 Q9DB67 uc009gea.1 uc009gea.2 Functions as a cytoplasmic linker protein. Involved in TGN- endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity). Homodimer. Interacts with AKT1 and AKT2; when AKT1 and AKT2 are phosphorylated and activated, affinity is higher for AKT2 (By similarity). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635). Cell membrane ; Lipid-anchor Cytoplasm Golgi apparatus, Golgi stack Note=Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae. Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD). Palmitoylation by ZDHHC17 regulates association with the plasma membrane. The N-terminal half is dispensable for proper Golgi targeting, whereas the GoLD region is required. Sequence=BAB23857.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; positive regulation of protein phosphorylation protein binding cytoplasm Golgi apparatus Golgi stack trans-Golgi network plasma membrane microtubule binding positive regulation of glucose transport membrane peptidyl-L-cysteine S-palmitoylation negative regulation of microtubule polymerization early endosome membrane trans-Golgi network membrane ganglioside binding positive regulation of apoptotic process membrane biogenesis membrane raft fat cell differentiation positive regulation of endocytosis recycling endosome membrane chaperone-mediated protein transport positive regulation of protein localization to plasma membrane uc009gea.1 uc009gea.2 
ENSMUST00000014118.4 Mcemp1 ENSMUST00000014118.4 mast cell expressed membrane protein 1 (from RefSeq NM_026985.2) ENSMUST00000014118.1 ENSMUST00000014118.2 ENSMUST00000014118.3 MCEM1_MOUSE Mcemp1 NM_026985 Q9D8U6 uc009ksi.1 uc009ksi.2 uc009ksi.3 Membrane ; Single- pass type II membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009ksi.1 uc009ksi.2 uc009ksi.3 
ENSMUST00000014174.14 Pax5 ENSMUST00000014174.14 paired box 5 (from RefSeq NM_008782.3) ENSMUST00000014174.1 ENSMUST00000014174.10 ENSMUST00000014174.11 ENSMUST00000014174.12 ENSMUST00000014174.13 ENSMUST00000014174.2 ENSMUST00000014174.3 ENSMUST00000014174.4 ENSMUST00000014174.5 ENSMUST00000014174.6 ENSMUST00000014174.7 ENSMUST00000014174.8 ENSMUST00000014174.9 NM_008782 PAX5_MOUSE Pax-5 Q02650 uc008srx.1 uc008srx.2 uc008srx.3 Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:9042861). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:16546096). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B- cell receptor signaling and promotes development to the mature B-cell stage (PubMed:9042861, PubMed:16546096). Repression of the cohesin- release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (By similarity). Interacts with ETS1; this interaction alters PAX5 DNA-binding properties. Binds DNA as a monomer. Interacts with TBP; this interaction allows PAX5 to interact with the basal transcription machinery. Interacts with RB1. Interacts with TLE4 (By similarity). Interacts with DAXX (PubMed:11799127). Q02650; Q6NZQ4: Paxip1; NbExp=3; IntAct=EBI-296260, EBI-1395317; Q02650; Q9UER7: DAXX; Xeno; NbExp=4; IntAct=EBI-296260, EBI-77321; Nucleus Expressed in all B-lymphoid organs, in the embryonic midbrain and in adult testis. O-glycosylated. Phosphorylated by SYK. This phosphorylation plays an important role in the abolition of BLIMP1 repression by PAX5 in order to trigger plasma cell differentiation. Mutant mice fail to produce small pre-B, B, and plasma cells and therefore lack any immunoglobulin in their serum owing to a complete arrest of B-cell development at an early stage. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding fibrillar center DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytosol regulation of transcription, DNA-templated multicellular organism development spermatogenesis nervous system development aging animal organ morphogenesis lateral ventricle development cerebral cortex development cell differentiation adult behavior skeletal muscle cell differentiation intracellular membrane-bounded organelle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic cranial skeleton morphogenesis negative regulation of histone H3-K9 methylation dopaminergic neuron differentiation uc008srx.1 uc008srx.2 uc008srx.3 
ENSMUST00000014218.15 Rnf168 ENSMUST00000014218.15 E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). (from UniProt Q80XJ2) BC046815 ENSMUST00000014218.1 ENSMUST00000014218.10 ENSMUST00000014218.11 ENSMUST00000014218.12 ENSMUST00000014218.13 ENSMUST00000014218.14 ENSMUST00000014218.2 ENSMUST00000014218.3 ENSMUST00000014218.4 ENSMUST00000014218.5 ENSMUST00000014218.6 ENSMUST00000014218.7 ENSMUST00000014218.8 ENSMUST00000014218.9 Q80XJ2 RN168_MOUSE Rnf168 uc289ecq.1 uc289ecq.2 E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Monomer. Interacts with UBE2N/UBC13. Nucleus Note=Localizes to double-strand breaks (DSBs) sites of DNA damage. The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs). Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs). Ubiquitinated. Belongs to the RNF168 family. According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8- dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys- 15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidence is however required to confirm these data. Sequence=AAH46815.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH46815.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; ubiquitin ligase complex chromatin binding ubiquitin-protein transferase activity nucleus nucleoplasm cytosol DNA repair double-strand break repair chromatin organization ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus response to ionizing radiation protein ubiquitination transferase activity nucleosome binding macromolecular complex histone H2A ubiquitination negative regulation of transcription elongation from RNA polymerase II promoter cellular response to UV histone H2A monoubiquitination site of double-strand break histone H2A-K13 ubiquitination histone H2A-K15 ubiquitination histone binding ubiquitin binding isotype switching positive regulation of DNA repair metal ion binding K63-linked polyubiquitin binding protein K63-linked ubiquitination histone H2A K63-linked ubiquitination regulation of cellular protein localization DNA repair complex uc289ecq.1 uc289ecq.2 
ENSMUST00000014220.15 Dynlt2b ENSMUST00000014220.15 dynein light chain Tctex-type 2B, transcript variant 3 (from RefSeq NR_154990.1) DYT2B_MOUSE ENSMUST00000014220.1 ENSMUST00000014220.10 ENSMUST00000014220.11 ENSMUST00000014220.12 ENSMUST00000014220.13 ENSMUST00000014220.14 ENSMUST00000014220.2 ENSMUST00000014220.3 ENSMUST00000014220.4 ENSMUST00000014220.5 ENSMUST00000014220.6 ENSMUST00000014220.7 ENSMUST00000014220.8 ENSMUST00000014220.9 NR_154990 Q9CQ66 Tctex1d2 uc007yyt.1 uc007yyt.2 uc007yyt.3 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. Required for proper retrograde ciliary transport. Light chain of the cytoplasmic dynein complex 2, a multisubunit complex composed at least of eleven different proteins. The cytoplasmic dynein 2 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs). Among them, a heavy chain (DYNC2H1), two intermediate chains (DYNC2I2 and DYNC2I1), a light intermediate chain (DYNC2LI1), and a light chain (DYNLT2B) are unique to the dynein-2 complex, but a subset of the light chains are also shared by dynein-1 and dynein-2 complexes. The dimer DYNLT2B-DYNLT1/DYNLT3 interacts with DYNC2I1; this interaction is crucial for retrograde trafficking of ciliary proteins. Dynein axonemal particle Belongs to the dynein light chain Tctex-type family. cytoplasmic dynein complex dynein intermediate chain binding cilium assembly regulation of cilium assembly spindle pole centrosome axoneme interphase microtubule organizing center ciliary base uc007yyt.1 uc007yyt.2 uc007yyt.3 
ENSMUST00000014221.13 Chp1 ENSMUST00000014221.13 calcineurin-like EF hand protein 1 (from RefSeq NM_019769.3) CHP1_MOUSE Chp ENSMUST00000014221.1 ENSMUST00000014221.10 ENSMUST00000014221.11 ENSMUST00000014221.12 ENSMUST00000014221.2 ENSMUST00000014221.3 ENSMUST00000014221.4 ENSMUST00000014221.5 ENSMUST00000014221.6 ENSMUST00000014221.7 ENSMUST00000014221.8 ENSMUST00000014221.9 NM_019769 P61022 Q62877 Q6ZWQ8 Sid470 uc008ltw.1 uc008ltw.2 uc008ltw.3 uc008ltw.4 Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membranes. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium- dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner (By similarity). Monomer. Interacts with STK17B; the interaction occurs in a calcium-independent manner and induces the translocation of CHP1 from the Golgi to the nucleus. Interacts with GAPDH; the interaction is direct, occurs in a N-myristoylation-dependent manner and facilitates the ability of CHP1 to bind microtubules. Interacts with KIF1B (via the C-terminal end of the kinesin-motor domain); the interaction occurs in a calcium-dependent manner. Associates (via C-terminal domain) with microtubules; the association occurs with polymerized microtubules during the cell cycle in a myristoylation- and calcium-independent manner and is enhanced by GAPDH. Interacts with PPP3CA. Interacts with SLC9A1/NHE1 (via the cytoplasmic C-terminal domain); the interaction occurs at the plasma membrane in a calcium-dependent manner and at a domain that is critical for growth factor stimulation of the exchanger (By similarity). Interacts with SLC9A3; increases SLC9A3 trafficking and activity at the plasma membrane (By similarity). Nucleus Cytoplasm Cytoplasm, cytoskeleton Endomembrane system Endoplasmic reticulum-Golgi intermediate compartment Endoplasmic reticulum Cell membrane Membrane ; Lipid-anchor Note=Localizes in cytoplasmic compartments in dividing cells. Localizes in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with SLC9A1 at the reticulum endoplasmic and plasma membrane. Colocalizes with STK17B at the plasma membrane. Phosphorylated; decreased phosphorylation is associated with an increase in SLC9A1/NHE1 Na(+)/H(+) exchange activity. Phosphorylation occurs in serum-dependent manner. The phosphorylation state may regulate the binding to SLC9A1/NHE1 (By similarity). Both N-myristoylation and calcium-mediated conformational changes are essential for its function in exocytic traffic. N-myristoylation is required for its association with microtubules and interaction with GAPDH, but not for the constitutive association to membranes (By similarity). Belongs to the calcineurin regulatory subunit family. CHP subfamily. Golgi membrane microtubule bundle formation negative regulation of protein phosphorylation protein kinase inhibitor activity calcium ion binding nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment cytosol cytoskeleton plasma membrane negative regulation of protein kinase activity protein export from nucleus microtubule binding negative regulation of phosphatase activity endomembrane system protein transport microtubule cytoskeleton membrane calcium ion regulated exocytosis kinase binding membrane docking transport vesicle cytoplasmic microtubule organization negative regulation of protein ubiquitination negative regulation of protein autophosphorylation negative regulation of NF-kappaB transcription factor activity positive regulation of sodium:proton antiporter activity negative regulation of protein import into nucleus transcytosis metal ion binding calcium-dependent protein binding protein stabilization positive regulation of protein transport protein oligomerization regulation of intracellular pH positive regulation of protein glycosylation membrane organization membrane fusion negative regulation of calcineurin-NFAT signaling cascade cellular response to acidic pH positive regulation of protein targeting to membrane regulation of neuron death uc008ltw.1 uc008ltw.2 uc008ltw.3 uc008ltw.4 
ENSMUST00000014248.11 Sval2 ENSMUST00000014248.11 seminal vesicle antigen-like 2 (from RefSeq NM_032542.2) ENSMUST00000014248.1 ENSMUST00000014248.10 ENSMUST00000014248.2 ENSMUST00000014248.3 ENSMUST00000014248.4 ENSMUST00000014248.5 ENSMUST00000014248.6 ENSMUST00000014248.7 ENSMUST00000014248.8 ENSMUST00000014248.9 NM_032542 Q99N75 Q99N75_MOUSE Sval2 mSLP-M slpm uc009bqi.1 uc009bqi.2 uc009bqi.3 Monomer. Interacts with AZGP1. Belongs to the PIP family. regulation of immune system process aspartic-type endopeptidase activity extracellular region extracellular space proteolysis uc009bqi.1 uc009bqi.2 uc009bqi.3 
ENSMUST00000014290.15 Apbb1ip ENSMUST00000014290.15 amyloid beta precursor protein binding family B member 1 interacting protein (from RefSeq NM_019456.2) AB1IP_MOUSE ENSMUST00000014290.1 ENSMUST00000014290.10 ENSMUST00000014290.11 ENSMUST00000014290.12 ENSMUST00000014290.13 ENSMUST00000014290.14 ENSMUST00000014290.2 ENSMUST00000014290.3 ENSMUST00000014290.4 ENSMUST00000014290.5 ENSMUST00000014290.6 ENSMUST00000014290.7 ENSMUST00000014290.8 ENSMUST00000014290.9 NM_019456 O35329 Prel1 Q8BRU0 Q8R5A3 Q99KV8 uc008ino.1 uc008ino.2 uc008ino.3 uc008ino.4 Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion (By similarity). Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, VASP and ENAH. Q8R5A3; P26039: Tln1; NbExp=8; IntAct=EBI-7450496, EBI-1039593; Cell membrane ; Peripheral membrane protein Cell projection, lamellipodium Cell junction, focal adhesion Cytoplasm, cytoskeleton Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases. Ubiquitously expressed with high expression in the hematopoietic system. Belongs to the MRL family. Sequence=AAB94880.1; Type=Frameshift; Evidence=; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell protein binding cytoplasm cytosol cytoskeleton plasma membrane focal adhesion signal transduction membrane lamellipodium cell junction T cell receptor complex cell projection positive regulation of cell adhesion uc008ino.1 uc008ino.2 uc008ino.3 uc008ino.4 
ENSMUST00000014321.5 Tvp23b ENSMUST00000014321.5 trans-golgi network vesicle protein 23B, transcript variant 1 (from RefSeq NM_026210.5) ENSMUST00000014321.1 ENSMUST00000014321.2 ENSMUST00000014321.3 ENSMUST00000014321.4 Fam18b Fam18b1 NM_026210 Q3UBJ3 Q9D8T4 TV23B_MOUSE uc007jkh.1 uc007jkh.2 uc007jkh.3 Membrane ; Multi-pass membrane protein Belongs to the TVP23 family. molecular_function protein secretion membrane integral component of membrane vesicle-mediated transport integral component of Golgi membrane uc007jkh.1 uc007jkh.2 uc007jkh.3 
ENSMUST00000014339.15 Dnajc7 ENSMUST00000014339.15 DnaJ heat shock protein family (Hsp40) member C7, transcript variant 1 (from RefSeq NM_019795.5) DNJC7_MOUSE ENSMUST00000014339.1 ENSMUST00000014339.10 ENSMUST00000014339.11 ENSMUST00000014339.12 ENSMUST00000014339.13 ENSMUST00000014339.14 ENSMUST00000014339.2 ENSMUST00000014339.3 ENSMUST00000014339.4 ENSMUST00000014339.5 ENSMUST00000014339.6 ENSMUST00000014339.7 ENSMUST00000014339.8 ENSMUST00000014339.9 NM_019795 Q3TKR1 Q6VVW6 Q8BPG3 Q8CIL2 Q9CT29 Q9D026 Q9QYI3 Ttc2 uc007lls.1 uc007lls.2 uc007lls.3 Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes (By similarity). Recruits NR1I3 to the cytoplasm. Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1. Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1. Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments. Interacts with HUS1 and RAD1 (By similarity). Interacts with NR1I3; this complex may also include HSP90 Interacts with HSPA8 (By similarity). Cytoplasm Nucleus Cytoplasm, cytoskeleton Note=Colocalizes with NR1I3 at microtubules. Widely expressed with high levels in liver, skeletal muscle, kidney and testis. nucleus nucleoplasm cytoplasm cytosol cytoskeleton heat shock protein binding chaperone mediated protein folding requiring cofactor uc007lls.1 uc007lls.2 uc007lls.3 
ENSMUST00000014370.11 Cacybp ENSMUST00000014370.11 calcyclin binding protein, transcript variant 1 (from RefSeq NM_009786.3) CYBP_MOUSE ENSMUST00000014370.1 ENSMUST00000014370.10 ENSMUST00000014370.2 ENSMUST00000014370.3 ENSMUST00000014370.4 ENSMUST00000014370.5 ENSMUST00000014370.6 ENSMUST00000014370.7 ENSMUST00000014370.8 ENSMUST00000014370.9 NM_009786 O70140 Q9CXW3 Sip uc007deg.1 uc007deg.2 uc007deg.3 uc007deg.4 May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). Monomer or homodimer. Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1 (By similarity). Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity). Q9CXW3; P14069: S100a6; NbExp=4; IntAct=EBI-767146, EBI-6478740; Q9CXW3; P02639: S100A1; Xeno; NbExp=4; IntAct=EBI-767146, EBI-6477285; Q9CXW3; P02638: S100B; Xeno; NbExp=4; IntAct=EBI-767146, EBI-458452; Q9CXW3; P25815: S100P; Xeno; NbExp=2; IntAct=EBI-767146, EBI-743700; Nucleus Cytoplasm Note=Cytoplasmic in unstimulated cultured neurons. Upon increase of calcium, it localizes to a ring around the nucleus. In neuroblastoma cells, after a Retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear and perinuclear fractions may be phosphorylated. Highly expressed in brain and EAT cells. Expressed at low level in heart, muscle, and at very low level in the liver, spleen, lung, kidney and stomach. Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations. Sequence=AAC16757.1; Type=Erroneous initiation; Evidence=; protein binding nucleus nuclear envelope lumen nucleoplasm cytoplasm cytosol heart development aging tubulin binding SCF ubiquitin ligase complex protein domain specific binding beta-catenin destruction complex ubiquitin protein ligase binding protein homodimerization activity neuron projection cell body S100 protein binding positive regulation of DNA replication cardiac muscle cell differentiation response to growth hormone negative regulation of cell death cellular response to calcium ion cellular response to leukemia inhibitory factor uc007deg.1 uc007deg.2 uc007deg.3 uc007deg.4 
ENSMUST00000014389.6 Pigl ENSMUST00000014389.6 phosphatidylinositol glycan anchor biosynthesis, class L, transcript variant 1 (from RefSeq NM_001039536.4) ENSMUST00000014389.1 ENSMUST00000014389.2 ENSMUST00000014389.3 ENSMUST00000014389.4 ENSMUST00000014389.5 Gm737 NM_001039536 PIGL_MOUSE Q5SX19 uc007jje.1 uc007jje.2 uc007jje.3 Catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N- acetylglucosaminyl-phosphatidylinositol. Reaction=a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo- inositol + H2O = acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn- glycero-3-phospho)-1D-myo-inositol; Xref=Rhea:RHEA:11660, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:57265, ChEBI:CHEBI:57997; EC=3.5.1.89; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11661; Evidence=; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Retained in the ER by two retention signals, one located in cytoplasmic domain, and a second signal in transmembrane domain that is functional in the presence of membrane proximal residues of the cytoplasmic tail. Deficient mice exhibit early lethality (9.5-10.5 dpc) and is associated with severe placental malformations. Belongs to the PIGL family. N-acetylglucosaminylphosphatidylinositol deacetylase activity cellular_component endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process membrane integral component of membrane hydrolase activity uc007jje.1 uc007jje.2 uc007jje.3 
ENSMUST00000014438.5 Ndufa2 ENSMUST00000014438.5 NADH:ubiquinone oxidoreductase subunit A2 (from RefSeq NM_010885.5) ENSMUST00000014438.1 ENSMUST00000014438.2 ENSMUST00000014438.3 ENSMUST00000014438.4 NDUA2_MOUSE NM_010885 Q9CQ75 Q9WUB2 uc008eoj.1 uc008eoj.2 uc008eoj.3 uc008eoj.4 This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. The human ortholog of this gene has been characterized, and its structure and redox potential is reported to be similar to that of thioredoxins. It may be involved in regulating complex I activity or assembly via assistance in redox processes. In humans, mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. A pseudogene of this gene is located on chromosome 5. [provided by RefSeq, May 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ746689.1, CD769118.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN00849385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 23038253; reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Acetylation of Lys-64 and Lys-75 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the complex I NDUFA2 subunit family. blastocyst hatching mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I NADH dehydrogenase (ubiquinone) activity membrane mitochondrial membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc008eoj.1 uc008eoj.2 uc008eoj.3 uc008eoj.4 
ENSMUST00000014445.7 Pam16 ENSMUST00000014445.7 presequence translocase-asssociated motor 16 (from RefSeq NM_025571.1) ENSMUST00000014445.1 ENSMUST00000014445.2 ENSMUST00000014445.3 ENSMUST00000014445.4 ENSMUST00000014445.5 ENSMUST00000014445.6 Magmas NM_025571 Pam16 Q6EIX1 Q9CQV1 TIM16_MOUSE Tim16 Timm16 uc007xzx.1 uc007xzx.2 uc007xzx.3 Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Interacts with DNAJC19. Directly interacts with DNAJC15; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity (By similarity). Associates with the TIM23 complex (Probable). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Expressed in trabecular bone and cartilage and by differentiated chondrocytes localized in the hypertrophic zone and by osteoblasts at early developmental stages. The J-like region, although related to the J domain does not have co-chaperone activity. Belongs to the TIM16/PAM16 family. presequence translocase-associated import motor ossification molecular_function cytoplasm mitochondrion mitochondrial inner membrane mitochondrial inner membrane presequence translocase complex mitochondrial matrix protein transport membrane protein import into mitochondrial matrix extrinsic component of mitochondrial inner membrane negative regulation of ATPase activity macromolecular complex negative regulation of apoptotic process DNA biosynthetic process negative regulation of release of cytochrome c from mitochondria negative regulation of apoptotic DNA fragmentation negative regulation of apoptotic signaling pathway uc007xzx.1 uc007xzx.2 uc007xzx.3 
ENSMUST00000014447.13 Glis2 ENSMUST00000014447.13 GLIS family zinc finger 2 (from RefSeq NM_031184.3) ENSMUST00000014447.1 ENSMUST00000014447.10 ENSMUST00000014447.11 ENSMUST00000014447.12 ENSMUST00000014447.2 ENSMUST00000014447.3 ENSMUST00000014447.4 ENSMUST00000014447.5 ENSMUST00000014447.6 ENSMUST00000014447.7 ENSMUST00000014447.8 ENSMUST00000014447.9 GLIS2_MOUSE Gli5 NM_031184 Nkl Q8R4X9 Q8VDL9 Q99MY6 Q99P73 uc007xzw.1 uc007xzw.2 Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog- dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation. Interacts with CTBP1 and HDAC3. Interacts with CTNNB1 and CTNND1. Interacts with SUFU. Nucleus speckle. Cytoplasm. Expressed at high levels in kidney, and at lower levels in heart and lung. Expression begins at 9.5 dpc in cranial ganglia, dorsal root ganglia and neural tube. At 10.5 dpc, broadly expressed in the intermediate zone of the hindbrain, spinal cord and dorsal root ganglia. By 12.5 dpc, expression in the spinal cord becomes restricted to a narrow band of cells in the ventricular zone. The C2H2-type zinc finger 1 has a major repressor function and is required for CTNNB1 binding. C-terminus cleavage is induced by interaction with CTNND1 and enhances by Src tyrosine kinase. Belongs to the GLI C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding kidney development nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm regulation of transcription from RNA polymerase II promoter multicellular organism development nervous system development central nervous system development nuclear speck cell differentiation negative regulation of sequence-specific DNA binding transcription factor activity transcription regulatory region DNA binding negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding regulation of transcription from RNA polymerase II promoter involved in kidney development cell differentiation involved in kidney development non-motile cilium positive regulation of protein localization to nucleus uc007xzw.1 uc007xzw.2 
ENSMUST00000014457.15 Cox6c ENSMUST00000014457.15 cytochrome c oxidase subunit 6C (from RefSeq NM_053071.2) COX6C_MOUSE ENSMUST00000014457.1 ENSMUST00000014457.10 ENSMUST00000014457.11 ENSMUST00000014457.12 ENSMUST00000014457.13 ENSMUST00000014457.14 ENSMUST00000014457.2 ENSMUST00000014457.3 ENSMUST00000014457.4 ENSMUST00000014457.5 ENSMUST00000014457.6 ENSMUST00000014457.7 ENSMUST00000014457.8 ENSMUST00000014457.9 NM_053071 Q52KC6 Q9CPQ1 uc007vmi.1 uc007vmi.2 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Energy metabolism; oxidative phosphorylation. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Mitochondrion inner membrane ; Single-pass membrane protein Acetylation of Lys-61 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the cytochrome c oxidase subunit 6c family. molecular_function cytochrome-c oxidase activity mitochondrion mitochondrial inner membrane biological_process membrane integral component of membrane electron transport chain hydrogen ion transmembrane transport uc007vmi.1 uc007vmi.2 
ENSMUST00000014476.6 Klra8 ENSMUST00000014476.6 killer cell lectin-like receptor, subfamily A, member 8, transcript variant 2 (from RefSeq NM_010650.3) ENSMUST00000014476.1 ENSMUST00000014476.2 ENSMUST00000014476.3 ENSMUST00000014476.4 ENSMUST00000014476.5 KLRA8_MOUSE Ly-49h Ly49-h Ly49H NM_010650 O78027 Q60682 uc009ehp.1 uc009ehp.2 uc009ehp.3 uc009ehp.4 uc009ehp.5 Receptor on natural killer (NK) cells for class I MHC. Homodimer; disulfide-linked. Interacts with the adapter protein TYROBP/DAP12; the interaction leads to natural killer cell activation (PubMed:9647200). Cell membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=H1; IsoId=Q60682-1; Sequence=Displayed; Name=H2; IsoId=Q60682-2; Sequence=VSP_003071; protein binding plasma membrane cell adhesion response to virus cell surface membrane integral component of membrane carbohydrate binding uc009ehp.1 uc009ehp.2 uc009ehp.3 uc009ehp.4 uc009ehp.5 
ENSMUST00000014499.10 Anapc1 ENSMUST00000014499.10 anaphase promoting complex subunit 1 (from RefSeq NM_008569.2) A2ATQ4 APC1_MOUSE ENSMUST00000014499.1 ENSMUST00000014499.2 ENSMUST00000014499.3 ENSMUST00000014499.4 ENSMUST00000014499.5 ENSMUST00000014499.6 ENSMUST00000014499.7 ENSMUST00000014499.8 ENSMUST00000014499.9 Mcpr NM_008569 P53995 Q8BP33 Q8C772 Tsg24 uc008mgq.1 uc008mgq.2 uc008mgq.3 uc008mgq.4 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Protein modification; protein ubiquitination. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. Abundantly expressed in proliferating fibroblasts, juvenile testis, adult brain and epididymis. Uniformly expressed throughout interphase of the cell cycle. Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis (By similarity). Belongs to the APC1 family. protein binding nucleus anaphase-promoting complex cell cycle metaphase/anaphase transition of mitotic cell cycle protein ubiquitination anaphase-promoting complex-dependent catabolic process cell division protein K11-linked ubiquitination uc008mgq.1 uc008mgq.2 uc008mgq.3 uc008mgq.4 
ENSMUST00000014505.5 Mertk ENSMUST00000014505.5 MER proto-oncogene tyrosine kinase, transcript variant 2 (from RefSeq NM_008587.3) ENSMUST00000014505.1 ENSMUST00000014505.2 ENSMUST00000014505.3 ENSMUST00000014505.4 MERTK_MOUSE Mer NM_008587 Q60805 Q62194 uc008mgt.1 uc008mgt.2 uc008mgt.3 Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6. Interacts with VAV1 in a phosphotyrosine-independent manner. Interacts with TIMD4; this interaction enhances TIMD4-mediated efferocytosis (By similarity). Cell membrane ; Single-pass type I membrane protein Expressed predominantly in the hematopoietic lineages: macrophages, NK cells, NKT cells, dendritic cells and platelets. Expressed during most, if not all, stages of embryological development beginning in the morula and blastocyst and progressing through the yolk sac and fetal liver stages. Autophosphorylated on Tyr-744, Tyr-748 and Tyr-749 in the activation loop allowing full activity (By similarity). Autophosphorylated on Tyr-867 leading to recruitment of downstream partners of the signaling cascade such as PLCG2. knockout mice are fertile, but male animals that lack all three receptors TYRO3, AXL and MERTK produce no mature sperm. Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. nucleotide binding photoreceptor outer segment natural killer cell differentiation negative regulation of cytokine production protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding extracellular space cytoplasm integral component of plasma membrane protein phosphorylation phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway spermatogenesis nervous system development membrane integral component of membrane rhabdomere kinase activity phosphorylation cell migration transferase activity peptidyl-tyrosine phosphorylation platelet activation secretion by cell substrate adhesion-dependent cell spreading receptor complex apoptotic cell clearance protein kinase B signaling positive regulation of phagocytosis negative regulation of lymphocyte activation retina development in camera-type eye vagina development neutrophil clearance negative regulation of leukocyte apoptotic process uc008mgt.1 uc008mgt.2 uc008mgt.3 
ENSMUST00000014545.11 Ldhc ENSMUST00000014545.11 lactate dehydrogenase C, transcript variant 1 (from RefSeq NM_013580.4) ENSMUST00000014545.1 ENSMUST00000014545.10 ENSMUST00000014545.2 ENSMUST00000014545.3 ENSMUST00000014545.4 ENSMUST00000014545.5 ENSMUST00000014545.6 ENSMUST00000014545.7 ENSMUST00000014545.8 ENSMUST00000014545.9 Ldh3 Ldhc NM_013580 Q548Z6 Q548Z6_MOUSE uc009gzp.1 uc009gzp.2 uc009gzp.3 Possible role in sperm motility. Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate; Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27; Evidence=; Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. Homotetramer. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2. Belongs to the LDH/MDH superfamily. LDH family. catalytic activity L-lactate dehydrogenase activity cytoplasm carbohydrate metabolic process oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor carboxylic acid metabolic process oxidation-reduction process uc009gzp.1 uc009gzp.2 uc009gzp.3 
ENSMUST00000014546.15 Tsg101 ENSMUST00000014546.15 tumor susceptibility gene 101, transcript variant 1 (from RefSeq NM_021884.5) ENSMUST00000014546.1 ENSMUST00000014546.10 ENSMUST00000014546.11 ENSMUST00000014546.12 ENSMUST00000014546.13 ENSMUST00000014546.14 ENSMUST00000014546.2 ENSMUST00000014546.3 ENSMUST00000014546.4 ENSMUST00000014546.5 ENSMUST00000014546.6 ENSMUST00000014546.7 ENSMUST00000014546.8 ENSMUST00000014546.9 NM_021884 Q61187 TS101_MOUSE uc009gzq.1 uc009gzq.2 uc009gzq.3 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity). Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with VPS37A, VPS37B and VPS37C. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with DMAP1 (PubMed:10888872). Interacts with GMCL (PubMed:12927808). Interacts with ubiquitin, stathmin and AATF (By similarity). Interacts with HGS; the interaction mediates the association with the ESCRT-0 complex (PubMed:12802020). Interacts with GGA1 and GGA3. Interacts (via UEV domain) with PDCD6IP/AIP1. Interacts with VPS28, SNF8 and VPS36. Self-associates. Interacts with MVB12A; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37D. Interacts with LRSAM1. Interacts with CEP55; the interaction is required for cytokinesis (By similarity). Interacts with PDCD6. Interacts with LITAF (By similarity). Interacts with murine leukemia virus Gag polyprotein (via PSAP motif) (PubMed:15908698). Interacts with MGRN1 (PubMed:19703557). Interacts with ARRDC1; recruits TSG101 to the plasma membrane (By similarity). Cytoplasm Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Late endosome membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody, Midbody ring Nucleus Note=Mainly cytoplasmic. Membrane- associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis. Ubiquitous. Higher expression in brain and mammary gland. Lower expression in liver and tumoral tissues. Expressed at all stages of mammary gland development, but at lower rate at early and mid pregnancy. Expressed in 1-cell and 2-cell stage embryos. The UEV domain is required for the interaction of the complex with ubiquitin. The coiled coil domain may interact with stathmin. Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the presence of UBE2D1. Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. ESCRT I complex regulation of cell growth transcription corepressor activity protein binding nucleus nucleolus cytoplasm endosome early endosome late endosome microtubule organizing center cytosol cytoskeleton plasma membrane cellular protein modification process protein monoubiquitination extracellular transport cell cycle cell cycle arrest negative regulation of epidermal growth factor-activated receptor activity negative regulation of cell proliferation endosome to lysosome transport endosome membrane protein transport membrane viral process cell differentiation keratinocyte differentiation ligand-dependent nuclear receptor transcription coactivator activity ubiquitin protein ligase binding early endosome membrane late endosome membrane regulation of growth negative regulation of epidermal growth factor receptor signaling pathway protein homodimerization activity ubiquitin binding ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway regulation of MAP kinase activity macromolecular complex binding negative regulation of transcription, DNA-templated viral budding virion binding calcium-dependent protein binding cell division extracellular exosome Flemming body positive regulation of viral release from host cell positive regulation of nucleic acid-templated transcription positive regulation of exosomal secretion regulation of extracellular exosome assembly positive regulation of viral budding via host ESCRT complex exosomal secretion positive regulation of ubiquitin-dependent endocytosis uc009gzq.1 uc009gzq.2 uc009gzq.3 
ENSMUST00000014562.14 Hps5 ENSMUST00000014562.14 HPS5, biogenesis of lysosomal organelles complex 2 subunit 2, transcript variant 2 (from RefSeq NM_001005248.2) ENSMUST00000014562.1 ENSMUST00000014562.10 ENSMUST00000014562.11 ENSMUST00000014562.12 ENSMUST00000014562.13 ENSMUST00000014562.2 ENSMUST00000014562.3 ENSMUST00000014562.4 ENSMUST00000014562.5 ENSMUST00000014562.6 ENSMUST00000014562.7 ENSMUST00000014562.8 ENSMUST00000014562.9 G3X8S7 HPS5_MOUSE NM_001005248 P59438 Ru2 uc012fkw.1 uc012fkw.2 uc012fkw.3 May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS6 and HPS3. May interact with all alpha-integrin chains that have an aromatic residue before the first lysine of the conserved KXGFFKR motif, including ITGA2, ITGA3, ITGA5 and ITGA6. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P59438-1; Sequence=Displayed; Name=2; IsoId=P59438-2; Sequence=VSP_007036; Name=3; IsoId=P59438-3; Sequence=VSP_007037, VSP_007038; Widely expressed, with lowest expression in skeletal muscle and spleen. Note=Defects in Hps5 are the cause of Hermansky-Pudlak-like syndrome, a syndrome characterized by hypopigmented eyes and coat, melanosomes greatly reduced in number and morphologically bizarre, kidney proximal tubules secreting lysosomal enzymes into urine at greatly reduced rates, platelet dense granules deficient in critical components, such as serotonin and adenine nucleotides, leading to functionally abnormal platelets and prolonged bleeding times, and mast cell granules undergoing unregulated 'kiss-and-run' fusion at the plasma membrane. Belongs to the HPS5 family. protein binding cytoplasm cytosol organelle organization blood coagulation BLOC-2 complex pigmentation uc012fkw.1 uc012fkw.2 uc012fkw.3 
ENSMUST00000014578.7 Plg ENSMUST00000014578.7 plasminogen (from RefSeq NM_008877.3) ENSMUST00000014578.1 ENSMUST00000014578.2 ENSMUST00000014578.3 ENSMUST00000014578.4 ENSMUST00000014578.5 ENSMUST00000014578.6 NM_008877 P20918 PLMN_MOUSE Q8CIS2 Q91WJ5 uc008akt.1 uc008akt.2 uc008akt.3 uc008akt.4 Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity). Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. Reaction=Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.; EC=3.4.21.7; Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Cannot be activated with streptokinase. Interacts (both mature PLG and the angiostatin peptide) with AMOT and CSPG4. Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation. Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4. Angiostatin: Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin. Secreted Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface (By similarity). Kringle domains mediate interaction with CSPG4. In the presence of the inhibitor, the activation involves only cleavage after Arg-581, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide (By similarity). Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot. In the presence of the inhibitor, the activation involves only cleavage after Arg-581, resulting in 2 chains held together by 2 disulfide bonds. Without the inhibitor, the activation involves also removal of the activation peptide. Belongs to the peptidase S1 family. Plasminogen subfamily. endopeptidase activity serine-type endopeptidase activity receptor binding extracellular region extracellular space plasma membrane proteolysis blood coagulation hemostasis peptidase activity serine-type peptidase activity cell surface negative regulation of cell-substrate adhesion negative regulation of angiogenesis hydrolase activity extrinsic component of plasma membrane enzyme binding kinase binding protein domain specific binding extracellular matrix disassembly extrinsic component of external side of plasma membrane apolipoprotein binding tissue regeneration fibrinolysis intracellular membrane-bounded organelle positive regulation of blood vessel endothelial cell migration other organism cell membrane myoblast differentiation muscle cell cellular homeostasis tissue remodeling chaperone binding proteolysis involved in cellular protein catabolic process interaction with symbiont negative regulation of fibrinolysis positive regulation of fibrinolysis interaction with symbiont via secreted substance involved in symbiotic interaction trophoblast giant cell differentiation labyrinthine layer blood vessel development mononuclear cell migration glutamatergic synapse proteasome core complex binding protein antigen binding uc008akt.1 uc008akt.2 uc008akt.3 uc008akt.4 
ENSMUST00000014597.5 Blk ENSMUST00000014597.5 B lymphoid kinase (from RefSeq NM_007549.2) BLK_MOUSE ENSMUST00000014597.1 ENSMUST00000014597.2 ENSMUST00000014597.3 ENSMUST00000014597.4 NM_007549 P16277 Q8K2M8 uc007uhq.1 uc007uhq.2 uc007uhq.3 Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (PubMed:2404338, PubMed:7690139, PubMed:7608542, PubMed:9636152, PubMed:14662906, PubMed:12563261). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:2404338, PubMed:7690139, PubMed:7608542, PubMed:14662906, PubMed:12563261). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (PubMed:2404338, PubMed:7690139, PubMed:7608542, PubMed:14662906, PubMed:12563261). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (PubMed:7592958, PubMed:9177269). Phosphorylates also the immunoglobulin G receptor FCGR2 (By similarity). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (PubMed:14662906, PubMed:12563261). Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (PubMed:7565679). In pancreatic islets, acts as a modulator of beta- cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (By similarity). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Antibody-mediated surface engagement of the B-cell antigen receptor (BCR) which results in the phosphorylation of BLK on tyrosine residues, stimulates the enzymatic activity. Interacts with CBL (via SH2 domain) (By similarity). Interacts with CD79A and CD79B (via SH2 domain). Cell membrane ; Lipid-anchor Note=Present and active in lipid rafts (By similarity). Membrane location is required for the phosphorylation of CD79A and CD79B. Expressed in immature Vgamma2 gamma-delta T-cells (at protein level) (PubMed:23562159). Expressed in the B-cell lineage (PubMed:2404338, PubMed:1537861). Expression increases during B-cell differentiation and is under the control of the B-cell specific transcription factors PAX5 and NF-kappa-B. Phosphorylated on tyrosine residues after antibody-mediated surface engagement of the B-cell antigen receptor (BCR). Ubiquitination of activated BLK by the UBE3A ubiquitin protein ligase leads to its degradation by the ubiquitin-proteasome pathway. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding cytosol plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation cell differentiation extrinsic component of cytoplasmic side of plasma membrane positive regulation of insulin secretion peptidyl-tyrosine autophosphorylation regulation of cell proliferation B cell receptor signaling pathway uc007uhq.1 uc007uhq.2 uc007uhq.3 
ENSMUST00000014614.4 Rnf166 ENSMUST00000014614.4 ring finger protein 166, transcript variant 2 (from RefSeq NM_001368370.1) ENSMUST00000014614.1 ENSMUST00000014614.2 ENSMUST00000014614.3 NM_001368370 Q3U9F6 RN166_MOUSE uc009nsx.1 uc009nsx.2 E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interferon production or autophagy. Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6. Also plays a role in the early recruitment of autophagy adapters to bacteria. Mediates 'Lys- 29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Cytoplasm metal ion binding uc009nsx.1 uc009nsx.2 
ENSMUST00000014640.9 Ankrd28 ENSMUST00000014640.9 ankyrin repeat domain 28, transcript variant 2 (from RefSeq NR_175291.1) ANR28_MOUSE ENSMUST00000014640.1 ENSMUST00000014640.2 ENSMUST00000014640.3 ENSMUST00000014640.4 ENSMUST00000014640.5 ENSMUST00000014640.6 ENSMUST00000014640.7 ENSMUST00000014640.8 NR_175291 Q505D1 uc007sya.1 uc007sya.2 uc007sya.3 Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation (By similarity). Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain- containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3 (By similarity). Nucleus, nucleoplasm. Note=Seems to be excluded from nucleoli. Widely expressed (at protein level). cellular_component nucleus nucleoplasm biological_process uc007sya.1 uc007sya.2 uc007sya.3 
ENSMUST00000014642.10 Ankrd52 ENSMUST00000014642.10 ankyrin repeat domain 52 (from RefSeq NM_172790.2) ANR52_MOUSE ENSMUST00000014642.1 ENSMUST00000014642.2 ENSMUST00000014642.3 ENSMUST00000014642.4 ENSMUST00000014642.5 ENSMUST00000014642.6 ENSMUST00000014642.7 ENSMUST00000014642.8 ENSMUST00000014642.9 NM_172790 Q148Z3 Q8BTI7 uc007hmm.1 uc007hmm.2 uc007hmm.3 Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain- containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1 (By similarity). molecular_function cellular_component biological_process uc007hmm.1 uc007hmm.2 uc007hmm.3 
ENSMUST00000014647.9 Pkd2l2 ENSMUST00000014647.9 polycystic kidney disease 2-like 2, transcript variant 1 (from RefSeq NM_016927.3) B2RS50 ENSMUST00000014647.1 ENSMUST00000014647.2 ENSMUST00000014647.3 ENSMUST00000014647.4 ENSMUST00000014647.5 ENSMUST00000014647.6 ENSMUST00000014647.7 ENSMUST00000014647.8 NM_016927 PK2L2_MOUSE Q9JLG4 uc008ekm.1 uc008ekm.2 uc008ekm.3 uc008ekm.4 uc008ekm.5 May function as a subunit of a cation channel and play a role in fertilization. Membrane ; Multi-pass membrane protein Expressed only in testis and heart. Belongs to the polycystin family. calcium channel activity calcium ion binding ion transport membrane integral component of membrane detection of mechanical stimulus calcium ion transmembrane transport uc008ekm.1 uc008ekm.2 uc008ekm.3 uc008ekm.4 uc008ekm.5 
ENSMUST00000014673.9 Tmbim7 ENSMUST00000014673.9 transmembrane BAX inhibitor motif containing 7, transcript variant 2 (from RefSeq NM_029141.4) 4930511M11Rik ENSMUST00000014673.1 ENSMUST00000014673.2 ENSMUST00000014673.3 ENSMUST00000014673.4 ENSMUST00000014673.5 ENSMUST00000014673.6 ENSMUST00000014673.7 ENSMUST00000014673.8 NM_029141 Q9D592 Q9D592_MOUSE Tmbim7 uc008whk.1 uc008whk.2 uc008whk.3 uc008whk.4 Membrane ; Multi- pass membrane protein Belongs to the BI1 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008whk.1 uc008whk.2 uc008whk.3 uc008whk.4 
ENSMUST00000014684.6 U2af1 ENSMUST00000014684.6 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1, transcript variant 1 (from RefSeq NM_024187.4) ENSMUST00000014684.1 ENSMUST00000014684.2 ENSMUST00000014684.3 ENSMUST00000014684.4 ENSMUST00000014684.5 NM_024187 Q564E4 Q99LX2 Q9CZ98 Q9D883 U2AF1_MOUSE uc008bvo.1 uc008bvo.2 uc008bvo.3 uc008bvo.4 Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity). Identified in the spliceosome C complex (By similarity). Heterodimer with U2AF2 (By similarity). Interacts (via RS domain) with PHF5A (via N-terminus) (PubMed:18758164). Interacts with ZRANB2 (By similarity). Interacts with SDE2 (By similarity). Interacts with SF3B1 (By similarity). Nucleus Nucleus speckle Expressed in primary spermatocytes and elongating spermatids (at protein level). The C-terminal SR-rich domain is required for interactions with SR proteins and the splicing regulators TRA and TRA2, and the N- terminal domain is required for formation of the U2AF1/U2AF2 heterodimer. Belongs to the splicing factor SR family. mRNA splicing, via spliceosome nucleic acid binding RNA binding protein binding nucleus spliceosomal complex mRNA processing RNA splicing nuclear speck pre-mRNA 3'-splice site binding metal ion binding RS domain binding U2AF uc008bvo.1 uc008bvo.2 uc008bvo.3 uc008bvo.4 
ENSMUST00000014686.3 Clec4f ENSMUST00000014686.3 C-type lectin domain family 4, member f (from RefSeq NM_016751.3) A0A0R4IZZ5 A0A0R4IZZ5_MOUSE Clec4f ENSMUST00000014686.1 ENSMUST00000014686.2 NM_016751 uc009cnv.1 uc009cnv.2 uc009cnv.3 Membrane ; Single- pass type II membrane protein membrane integral component of membrane carbohydrate binding uc009cnv.1 uc009cnv.2 uc009cnv.3 
ENSMUST00000014687.11 Klra17 ENSMUST00000014687.11 killer cell lectin-like receptor, subfamily A, member 17, transcript variant 1 (from RefSeq NM_001381962.1) ENSMUST00000014687.1 ENSMUST00000014687.10 ENSMUST00000014687.2 ENSMUST00000014687.3 ENSMUST00000014687.4 ENSMUST00000014687.5 ENSMUST00000014687.6 ENSMUST00000014687.7 ENSMUST00000014687.8 ENSMUST00000014687.9 Klra17 Ly-49Q NM_001381962 Q9JMA4 Q9JMA4_MOUSE klra17 uc009egt.1 uc009egt.2 uc009egt.3 uc009egt.4 membrane integral component of membrane carbohydrate binding MHC class I protein binding uc009egt.1 uc009egt.2 uc009egt.3 uc009egt.4 
ENSMUST00000014691.10 Wdfy2 ENSMUST00000014691.10 WD repeat and FYVE domain containing 2 (from RefSeq NM_175546.4) ENSMUST00000014691.1 ENSMUST00000014691.2 ENSMUST00000014691.3 ENSMUST00000014691.4 ENSMUST00000014691.5 ENSMUST00000014691.6 ENSMUST00000014691.7 ENSMUST00000014691.8 ENSMUST00000014691.9 NM_175546 Q3U9F3 Q8BUB4 WDFY2_MOUSE uc007ugy.1 uc007ugy.2 uc007ugy.3 uc007ugy.4 Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (By similarity). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin- stimulated AKT2 phosphorylation and glucose uptake and insulin- stimulated phosphorylation of AKT2 substrates (PubMed:20189988). Participates in transferrin receptor endocytosis (By similarity). Homodimer (By similarity). Interacts (via WD repeats 1-3) with AKT1, AKT2, PRKCZ and PRKCI (PubMed:16792529, PubMed:20189988). Interacts with VAMP2 (PubMed:17313651). Forms a complex with VAMP2 and PRKCZ (PubMed:17313651). Interacts with FOXO1 (PubMed:18388859). Forms a complex with AKT1 and FOXO1 (PubMed:18388859). Endosome Early endosome Cytoplasm Note=Localizes to intracellular vesicles. Colocalizes with VAMP2 and PRKCZ in intracellular vesicles (By similarity). Colocalizes with AKT2 in early endosomes (PubMed:20189988). Highly expressed in the brain (at protein level). Transiently up-regulated during adipogenesis (at protein level). The FYVE-type zinc finger is essential for its vesicular localization. positive regulation of protein phosphorylation protein binding cytoplasm endosome early endosome vesicle positive regulation of fat cell differentiation metal ion binding uc007ugy.1 uc007ugy.2 uc007ugy.3 uc007ugy.4 
ENSMUST00000014694.11 Rbsn ENSMUST00000014694.11 rabenosyn, RAB effector (from RefSeq NM_030081.3) ENSMUST00000014694.1 ENSMUST00000014694.10 ENSMUST00000014694.2 ENSMUST00000014694.3 ENSMUST00000014694.4 ENSMUST00000014694.5 ENSMUST00000014694.6 ENSMUST00000014694.7 ENSMUST00000014694.8 ENSMUST00000014694.9 NM_030081 Q80Y56 Q8K0L6 Q9CTW0 RBNS5_MOUSE Rbsn Zfyve20 uc009cyv.1 uc009cyv.2 uc009cyv.3 Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). Plays a role in the recycling of transferrin receptor to the plasma membrane (By similarity). Interacts with EHD1, RAB4A, RAB5A, RAB22A, RAB24 and VPS45. Binds simultaneously to RAB4A and RAB5A in vitro. Interacts with RAB4A and RAB5A that has been activated by GTP binding (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Early endosome membrane ; Lipid-anchor Note=Enriched in endosomes that are in close proximity to clathrin- enriched regions at the cell surface (By similarity). nucleic acid binding endosome cytosol plasma membrane protein transport membrane Rab GTPase binding early endosome membrane early endosome to Golgi transport intracellular membrane-bounded organelle metal ion binding Golgi to lysosome transport regulation of Golgi organization uc009cyv.1 uc009cyv.2 uc009cyv.3 
ENSMUST00000014698.10 Dguok ENSMUST00000014698.10 deoxyguanosine kinase, transcript variant 5 (from RefSeq NR_177096.1) DGUOK_MOUSE Dgk ENSMUST00000014698.1 ENSMUST00000014698.2 ENSMUST00000014698.3 ENSMUST00000014698.4 ENSMUST00000014698.5 ENSMUST00000014698.6 ENSMUST00000014698.7 ENSMUST00000014698.8 ENSMUST00000014698.9 NR_177096 Q8CBU2 Q9QX60 Q9R0Y2 Q9WUT9 uc009cnn.1 uc009cnn.2 uc009cnn.3 uc009cnn.4 Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:10455141). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (PubMed:10455141). Widely used as target of antiviral and chemotherapeutic agents. Reaction=2'-deoxyguanosine + ATP = ADP + dGMP + H(+); Xref=Rhea:RHEA:19201, ChEBI:CHEBI:15378, ChEBI:CHEBI:17172, ChEBI:CHEBI:30616, ChEBI:CHEBI:57673, ChEBI:CHEBI:456216; EC=2.7.1.113; Evidence=; Reaction=2'-deoxyadenosine + ATP = ADP + dAMP + H(+); Xref=Rhea:RHEA:23452, ChEBI:CHEBI:15378, ChEBI:CHEBI:17256, ChEBI:CHEBI:30616, ChEBI:CHEBI:58245, ChEBI:CHEBI:456216; EC=2.7.1.76; Evidence=; Homodimer. [Isoform 1]: Mitochondrion [Isoform 2]: Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QX60-1; Sequence=Displayed; Name=2; IsoId=Q9QX60-2; Sequence=VSP_003027; Spleen and thymus. Expressed at much lower levels in the brain and liver. Belongs to the DCK/DGK family. nucleotide binding deoxyguanosine kinase activity ATP binding cytoplasm mitochondrion cytosol nucleobase-containing compound metabolic process protein phosphorylation deoxyribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process negative regulation of neuron projection development kinase activity phosphorylation transferase activity deoxynucleoside kinase activity nucleoside kinase activity dGTP metabolic process purine deoxyribonucleoside metabolic process uc009cnn.1 uc009cnn.2 uc009cnn.3 uc009cnn.4 
ENSMUST00000014743.10 Csf1 ENSMUST00000014743.10 colony stimulating factor 1 (macrophage), transcript variant 1 (from RefSeq NM_007778.4) CSF1_MOUSE Csfm ENSMUST00000014743.1 ENSMUST00000014743.2 ENSMUST00000014743.3 ENSMUST00000014743.4 ENSMUST00000014743.5 ENSMUST00000014743.6 ENSMUST00000014743.7 ENSMUST00000014743.8 ENSMUST00000014743.9 NM_007778 P07141 Q3U395 Q8R3C8 uc008qxk.1 uc008qxk.2 uc008qxk.3 Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Homodimer or heterodimer; disulfide-linked (PubMed:19017797). Likely to exist in multiple forms: homodimer consisting of 2 identical 150-200 kDa proteoglycan subunits, heterodimer consisting of a 150-200 kDa proteoglycan subunit and a truncated 43 kDa subunit, and homodimer consisting of 2 identical 43 kDa subunits (By similarity). Interacts with CSF1R (PubMed:19017797). P07141; Q8C161: Aar2; NbExp=2; IntAct=EBI-777188, EBI-777252; P07141; Q60771: Cldn11; NbExp=2; IntAct=EBI-777188, EBI-309095; P07141; P07141: Csf1; NbExp=3; IntAct=EBI-777188, EBI-777188; P07141; P09581: Csf1r; NbExp=6; IntAct=EBI-777188, EBI-6305373; P07141; Q9JHU4: Dync1h1; NbExp=2; IntAct=EBI-777188, EBI-645061; P07141; P05480: Src; NbExp=2; IntAct=EBI-777188, EBI-298680; P07141; P03228: BARF1; Xeno; NbExp=8; IntAct=EBI-777188, EBI-16007073; Cell membrane ; Single-pass type I membrane protein [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07141-1; Sequence=Displayed; Name=2; IsoId=P07141-2; Sequence=VSP_001189; N-glycosylated. O-glycosylated; contains chondroitin sulfate. Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling. The sequence reported in PubMed:8357831 was thought to originate from rat, but was later shown (PubMed:12074592, PubMed:12379742) to be derived from mouse. ossification positive regulation of cell-matrix adhesion osteoclast proliferation immune system process response to ischemia developmental process involved in reproduction cytokine activity macrophage colony-stimulating factor receptor binding protein binding extracellular region extracellular space plasma membrane inflammatory response transmembrane receptor protein tyrosine kinase signaling pathway growth factor activity cell proliferation positive regulation of cell proliferation positive regulation of gene expression positive regulation of macrophage derived foam cell differentiation positive regulation of macrophage chemotaxis membrane integral component of membrane macrophage differentiation regulation of ossification osteoclast differentiation positive regulation of cell migration positive regulation of cellular protein metabolic process positive regulation of mononuclear cell proliferation macrophage colony-stimulating factor signaling pathway positive regulation of multicellular organism growth odontogenesis positive regulation of odontogenesis of dentin-containing tooth identical protein binding protein homodimerization activity innate immune response positive regulation of macrophage differentiation positive regulation of monocyte differentiation positive regulation of osteoclast differentiation positive regulation of protein kinase activity positive regulation of Ras protein signal transduction perinuclear region of cytoplasm homeostasis of number of cells within a tissue branching involved in mammary gland duct morphogenesis mammary gland fat development mammary duct terminal end bud growth microglial cell proliferation negative regulation of neuron death positive regulation of macrophage colony-stimulating factor signaling pathway positive regulation of microglial cell migration CSF1-CSF1R complex uc008qxk.1 uc008qxk.2 uc008qxk.3 
ENSMUST00000014747.3 Alx3 ENSMUST00000014747.3 aristaless-like homeobox 3 (from RefSeq NM_007441.3) Alx3 ENSMUST00000014747.1 ENSMUST00000014747.2 NM_007441 Q3UQX2 Q3UQX2_MOUSE uc008qxf.1 uc008qxf.2 uc008qxf.3 uc008qxf.4 This gene belongs to Group 1 of aristaless-like genes, which are characterized by the presence of an aristaless domain and a conserved paired-like homeodomain. The encoded protein acts as a transcriptional regulator. The protein plays a role in the development of craniofacial and appendicular skeleton and may have a role in pancreatic function. [provided by RefSeq, Apr 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U96109.1, AK142019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Nucleus DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding embryonic cranial skeleton morphogenesis uc008qxf.1 uc008qxf.2 uc008qxf.3 uc008qxf.4 
ENSMUST00000014750.15 Slc25a11 ENSMUST00000014750.15 solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 (from RefSeq NM_024211.3) ENSMUST00000014750.1 ENSMUST00000014750.10 ENSMUST00000014750.11 ENSMUST00000014750.12 ENSMUST00000014750.13 ENSMUST00000014750.14 ENSMUST00000014750.2 ENSMUST00000014750.3 ENSMUST00000014750.4 ENSMUST00000014750.5 ENSMUST00000014750.6 ENSMUST00000014750.7 ENSMUST00000014750.8 ENSMUST00000014750.9 M2OM_MOUSE NM_024211 Q9CR62 uc007jvr.1 uc007jvr.2 uc007jvr.3 uc007jvr.4 uc007jvr.5 Catalyzes the transport of 2-oxoglutarate (alpha- oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity). Involved in the regulation of apoptosis (PubMed:21448454). Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity). Reaction=(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2- oxoglutarate(in); Xref=Rhea:RHEA:71587, ChEBI:CHEBI:15589, ChEBI:CHEBI:16810; Evidence=; Reaction=2-oxoglutarate(out) + malonate(in) = 2-oxoglutarate(in) + malonate(out); Xref=Rhea:RHEA:71591, ChEBI:CHEBI:15792, ChEBI:CHEBI:16810; Evidence=; Reaction=2-oxoglutarate(out) + succinate(in) = 2-oxoglutarate(in) + succinate(out); Xref=Rhea:RHEA:71595, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031; Evidence=; Reaction=2-oxoglutarate(out) + maleate(in) = 2-oxoglutarate(in) + maleate(out); Xref=Rhea:RHEA:71599, ChEBI:CHEBI:16810, ChEBI:CHEBI:30780; Evidence=; Reaction=2-oxoglutarate(out) + oxaloacetate(in) = 2-oxoglutarate(in) + oxaloacetate(out); Xref=Rhea:RHEA:71603, ChEBI:CHEBI:16452, ChEBI:CHEBI:16810; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. mitochondrion mitochondrial inner membrane alpha-ketoglutarate transmembrane transporter activity oxoglutarate:malate antiporter activity alpha-ketoglutarate transport membrane integral component of membrane malate transmembrane transport uc007jvr.1 uc007jvr.2 uc007jvr.3 uc007jvr.4 uc007jvr.5 
ENSMUST00000014830.8 Ceacam16 ENSMUST00000014830.8 CEA cell adhesion molecule 16 (from RefSeq NM_001033419.2) B2RUD6 CEA16_MOUSE E9QA28 ENSMUST00000014830.1 ENSMUST00000014830.2 ENSMUST00000014830.3 ENSMUST00000014830.4 ENSMUST00000014830.5 ENSMUST00000014830.6 ENSMUST00000014830.7 NM_001033419 uc009fnm.1 uc009fnm.2 Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane. Homooligomer; can for homodimers and homotetramers (By similarity). Interacts with TECTA and TECTB (PubMed:25080593). Secreted Note=Localizes at the tip of cochlear outer hair cells and to the tectorial membrane. Expressed in cochlear outer hair cells (OHC). Abundantly expressed in cochleae from embryonic day 17 to postnatal day 42. Mutant mice show loss of striated-sheet matrix and Hensen's stripe, a prominent feature in the basal two-thirds of the tectorial membrane. They have enhanced spontaneous, stimulus-frequency, and transiently evoked otoacoustic emissions. Belongs to the immunoglobulin superfamily. CEA family. protein binding extracellular region extracellular space sensory perception of sound stereocilium tip identical protein binding uc009fnm.1 uc009fnm.2 
ENSMUST00000014848.11 Hoxa2 ENSMUST00000014848.11 homeobox A2 (from RefSeq NM_010451.3) ENSMUST00000014848.1 ENSMUST00000014848.10 ENSMUST00000014848.2 ENSMUST00000014848.3 ENSMUST00000014848.4 ENSMUST00000014848.5 ENSMUST00000014848.6 ENSMUST00000014848.7 ENSMUST00000014848.8 ENSMUST00000014848.9 HXA2_MOUSE Hox-1.11 Hoxa-2 NM_010451 P31245 Q149U3 Q920T8 uc009bxz.1 uc009bxz.2 uc009bxz.3 This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is expressed in rhombomere 2 and is important for hindbrain formation in the early embryo. [provided by RefSeq, Mar 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M95599.1, BC117105.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus. Belongs to the Antp homeobox family. Proboscipedia subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding cell fate determination osteoblast development DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development segment specification pattern specification process motor neuron axon guidance anterior/posterior pattern specification dorsal/ventral pattern formation rhombomere 2 development rhombomere 3 development rhombomere 3 morphogenesis brain segmentation middle ear morphogenesis intracellular membrane-bounded organelle sequence-specific DNA binding cell fate commitment negative regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter embryonic viscerocranium morphogenesis embryonic skeletal system morphogenesis cellular response to retinoic acid uc009bxz.1 uc009bxz.2 uc009bxz.3 
ENSMUST00000014891.5 Ankrd53 ENSMUST00000014891.5 ankyrin repeat domain 53 (from RefSeq NM_029245.3) ANR53_MOUSE E9QN79 ENSMUST00000014891.1 ENSMUST00000014891.2 ENSMUST00000014891.3 ENSMUST00000014891.4 NM_029245 Q3V0J4 uc009cod.1 uc009cod.2 uc009cod.3 Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization. Interacts with PSRC1; recruited by PSRC1 to the spindle during mitosis. Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=Localizes at the spindle around the centrosome at prophase and prometaphase and at the spindle poles at metaphase and anaphase. Phosphorylated during mitosis. spindle pole molecular_function cytoplasm spindle cytoskeleton cell cycle mitotic metaphase plate congression positive regulation of microtubule polymerization cell division regulation of mitotic spindle organization regulation of mitotic cytokinesis uc009cod.1 uc009cod.2 uc009cod.3 
ENSMUST00000014892.8 Tex261 ENSMUST00000014892.8 testis expressed gene 261 (from RefSeq NM_009357.2) ENSMUST00000014892.1 ENSMUST00000014892.2 ENSMUST00000014892.3 ENSMUST00000014892.4 ENSMUST00000014892.5 ENSMUST00000014892.6 ENSMUST00000014892.7 NM_009357 Q62302 TX261_MOUSE uc009coe.1 uc009coe.2 uc009coe.3 uc009coe.4 Membrane ; Multi-pass membrane protein Detected in testis. Not detectable in testis from 6 day old animals. Detectable in testis 15 days after birth. Highly expressed in testis 20 days after birth. Highly expressed in meiotic and post-meiotic germ cells. Belongs to the SVP26 family. ER to Golgi vesicle-mediated transport membrane integral component of membrane ER to Golgi transport vesicle integral component of Golgi membrane integral component of endoplasmic reticulum membrane positive regulation of apoptotic process COPII adaptor activity uc009coe.1 uc009coe.2 uc009coe.3 uc009coe.4 
ENSMUST00000014913.11 Psmb1 ENSMUST00000014913.11 proteasome (prosome, macropain) subunit, beta type 1 (from RefSeq NM_011185.3) ENSMUST00000014913.1 ENSMUST00000014913.10 ENSMUST00000014913.2 ENSMUST00000014913.3 ENSMUST00000014913.4 ENSMUST00000014913.5 ENSMUST00000014913.6 ENSMUST00000014913.7 ENSMUST00000014913.8 ENSMUST00000014913.9 NM_011185 Psmb1 Q6RI64 Q6RI64_MOUSE uc008aol.1 uc008aol.2 uc008aol.3 Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Component of the proteasome complex. Cytoplasm Nucleus Belongs to the peptidase T1B family. proteasome complex endopeptidase activity threonine-type endopeptidase activity nucleus cytoplasm proteasome core complex proteolysis peptidase activity hydrolase activity proteolysis involved in cellular protein catabolic process uc008aol.1 uc008aol.2 uc008aol.3 
ENSMUST00000014917.8 Dll1 ENSMUST00000014917.8 delta like canonical Notch ligand 1, transcript variant 1 (from RefSeq NM_007865.3) DLL1_MOUSE ENSMUST00000014917.1 ENSMUST00000014917.2 ENSMUST00000014917.3 ENSMUST00000014917.4 ENSMUST00000014917.5 ENSMUST00000014917.6 ENSMUST00000014917.7 NM_007865 Q61483 Q6PFV7 uc008aoi.1 uc008aoi.2 uc008aoi.3 uc008aoi.4 Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:21985982, PubMed:10958687). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (PubMed:10958687, PubMed:18676613). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:17194759, PubMed:19562077, PubMed:18997111, PubMed:23695674, PubMed:16495313, PubMed:21238454, PubMed:22282195, PubMed:7671806, PubMed:17960184, PubMed:22529374, PubMed:19389377, PubMed:23699523, PubMed:19144989, PubMed:23688253, PubMed:23806616, PubMed:26114479, PubMed:22940113, PubMed:25220152, PubMed:20081190, PubMed:21572390, PubMed:22096075). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner (PubMed:7671806, PubMed:18997111). During neocortex development, Dll1- Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell- cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries (PubMed:23699523). During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway (PubMed:23688253). At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway (PubMed:19389377, PubMed:26114479). Also controls neurogenesis of the neural tube in a progenitor domain- specific fashion along the dorsoventral axis (PubMed:20081190). Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell (PubMed:23695674). Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B cells (PubMed:15146182, PubMed:19217325). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (By similarity). Upon MMP14 cleavage, negatively regulates Notch signaling in haematopoietic progenitor cells to specifically maintain normal B-cell development in bone marrow (PubMed:21572390). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation (PubMed:17194759). Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression (PubMed:22940113). During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression (PubMed:25220152). Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium (PubMed:22529374). Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels (PubMed:22096075). During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression (PubMed:19144989). Controls sprouting angiogenesis and subsequent vertical branch formation through regulation on tip cell differentiation (PubMed:22282195). Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine (PubMed:21238454, PubMed:21915337). Plays a role during inner ear development; negatively regulates auditory hair cell differentiation (PubMed:16495313). Plays a role during nephron development through Notch signaling pathway (PubMed:23806616). Regulates growth, blood pressure and energy homeostasis (PubMed:19562077). Homodimer (PubMed:12794186). Interacts with TJP1 (PubMed:24715457). Interacts with MMP14; inhibits DLL1-induced Notch signaling (PubMed:21572390). Interacts with MAGI1 (via PDZ domain); forms a complex with CTNNB1 and CDH2 and promotes recruitment to the adherens junction and stabilization on the cell surface (PubMed:15908431). Interacts with PSEN1; undergoes a presenilin- dependent gamma-secretase cleavage that releases a Dll1-intracellular form (PubMed:12794186). Interacts with MFAP5 (PubMed:15788413). Interacts with MIB1 (PubMed:21985982). Interacts with NEURL1B; leads to ubiquitination (PubMed:17003037, PubMed:19723503). Interacts with NEURL1 (PubMed:19723503). Interacts with SYNJ2BP; enhances DLL1 protein stability, and promotes Notch signaling in endothelial cells (By similarity). Interacts with MAGI1, MAGI2, MAGI3 and MPDZ (By similarity). Interacts (via ubiquitin) with EPN1 (via IUM domain); binding with NOTCH1 attached to neighboring cell, promotes ligand ubiquitination and EPN1 interaction, leading to NECD transendocytosis and Notch signaling. Interacts with NOTCH1 (By similarity). Q61483; Q9WVQ1: Magi2; NbExp=3; IntAct=EBI-297125, EBI-297151; Apical cell membrane ; Single-pass type I membrane protein Cell junction, adherens junction Membrane raft Note=Distributed around adherens junction in the apical endfeet through interactions with MAGI1. [Dll1-derived cell-associated form]: Cell membrane [Dll1-intracellular form]: Nucleus In the embryo, expressed in the paraxial mesoderm and nervous system. Expressed at high levels in adult heart and at lower levels, in adult lung. Highly expressed in satellite cells from masseter and tongue than in satellite cells from leg and extraocular muscle.? (PubMed:25220152). Expressed until 15 dpc. Expression then decreases and increases again in the adult. In differentiating somites, is expressed at low levels in cells emerging from the dorsomedial lip and subsequently throughout myotomes. In the limb buds, is found in myoblasts and myocytes but not in the progenitor cells (PubMed:17194759). Highly expressed in the endothelium and in the smooth muscle layer starting at 13.5 dpc in arterial vessels, but not in veins. At 12.5 dpc, there is no detectable expression in arteries or veins. This pattern persists until 18.5 dpc (PubMed:19144989). Strongly expressed in developing muscle of tongue, cheek, and in extraocular muscle at 11.5 dpc. Found at 18 dpc and P21 in head muscle (PubMed:25220152). Detected in a subset of cells in the ventricular zone (VZ), the intermediate zone (IZ) and the cortical plate (CP) of neocortex and in the ganglionic eminences at 13.5 dpc. At later stages, such as at 16.5 dpc, found in the VZ and IZ, but at very low levels in the CP of the neocortex (PubMed:18997111). Highly expressed in embryonic cells located in the ventricular zone (VZ) of the retinal neuroepithelium that form clusters; is first detected in cells located in the central retina. As the retina grows, expression spreads peripherally along the expanding neurogenic region, being always absent from the ciliary margin zone (CMZ) (PubMed:19389377). Induced by PTF1A in multipotent pancreatic progenitor cells (PubMed:22096075). Induced by CDX1 and CDX2 during somitogenesis and goblet cell differentiation (PubMed:22015720). Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. Ubiquitinated; promotes recycling back to the plasma membrane and confers a strong affinity for NOTCH1 (PubMed:18676613). Multi-ubiquitination of Lys-613 by MIB1 promotes both cis and trans-interaction with NOTCH1, as well as activation of Notch signaling (PubMed:21985982). Ubiquitinated by NEURL1B (PubMed:17003037). Phosphorylated in a membrane association-dependent manner. Phosphorylation at Ser-696 requires the presence of Ser-693, whereas phosphorylation at Thr-638 and Ser-693 occurs independently of the other sites. Phosphorylation is required for full ligand activity in vitro and affects surface presentation, ectodomain shedding, and endocytosis. Cleaved by MMP14; negatively regulates DLL1-induced Notch signaling in HPCs, modulating B-lymphocyte differentiation in bone marrow (PubMed:21572390). Undergoes two consecutive processing events: a shedding event, partially by ADAM10, that generates a soluble extracellular form and an intracellular membrane-anchored form, followed by a gamma-secretase cleavage releasing an intracellular fragment (PubMed:12794186). O-fucosylated. Can be elongated to a disaccharide by MFNG. Heterozygous Dll1 mice mutants are lighter and smaller, with altered fat to lean ratio and have increased blood pressure and a slight bradycardia. The animals have reduced cholesterol and triglyceride levels in blood (PubMed:19562077). Heterozygous Dll1 mice mutants and hypomorphic Dll1 mice mutants survive until birth, despite significantly reduced Notch activity (PubMed:17194759). Conditional knockout in inner ear leads to an early and excessive production of hair cells and have vestibular defects (PubMed:16495313). Conditional knockout in a small proportion of neural precursor cells reduces neurogenesis, whereas conditional knockout in a large proportion promotes premature neurogenesis (PubMed:18997111). Hypomorph Dll1 pups mutant survive until birth but are smaller. Conditional knockout Dll1 mice mutant in epidermis, survive and have no gross abnormalities (PubMed:17960184). Hypomorph Dll1 mice mutant survive until birth and have severe skeletal muscle defects (PubMed:19144989). Heterozygous Dll1 mutant embryos show disrupted muscle growth (PubMed:25220152). Conditional knockout Dll1 mice mutant show disorganization of Bergmann fibers, ectopic localization of Bergmann glia in the molecular layer and a reduction in the number of Bergmann glia (PubMed:23688253). in utero embryonic development somitogenesis somite specification heart looping marginal zone B cell differentiation type B pancreatic cell development Notch binding calcium ion binding protein binding nucleus plasma membrane adherens junction cell communication Notch signaling pathway cell-cell signaling multicellular organism development determination of left/right symmetry compartment pattern specification nervous system development regulation of blood pressure positive regulation of cell proliferation negative regulation of cell proliferation animal organ morphogenesis auditory receptor cell fate commitment proximal/distal pattern formation positive regulation of gene expression astrocyte development regulation of somitogenesis membrane integral component of membrane apical plasma membrane spinal cord development cerebellar molecular layer formation cerebellar Purkinje cell layer structural organization cell junction cell differentiation regulation of cell adhesion negative regulation of epithelial cell differentiation Tat protein binding cytoplasmic vesicle negative regulation of interleukin-10 production negative regulation of glial cell apoptotic process organ growth regulation of growth inner ear morphogenesis odontogenesis of dentin-containing tooth auditory receptor cell differentiation membrane raft negative regulation of cell differentiation negative regulation of epidermal cell differentiation negative regulation of auditory receptor cell differentiation negative regulation of myeloid cell differentiation negative regulation of myoblast differentiation negative regulation of neuron differentiation negative regulation of Notch signaling pathway positive regulation of Notch signaling pathway positive regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter lateral inhibition skeletal muscle tissue growth regulation of skeletal muscle tissue growth positive regulation of skeletal muscle tissue growth neuron fate specification inner ear development regulation of neurogenesis regulation of cell division retina development in camera-type eye retina morphogenesis in camera-type eye Notch signaling pathway involved in arterial endothelial cell fate commitment Notch signaling involved in heart development left/right axis specification nephron development proximal tubule development loop of Henle development clathrin-dependent endocytosis energy homeostasis endothelial tip cell fate specification scaffold protein binding neuronal stem cell population maintenance skin epidermis development regulation of vascular endothelial growth factor signaling pathway positive regulation of sprouting angiogenesis negative regulation of cardiac muscle cell differentiation uc008aoi.1 uc008aoi.2 uc008aoi.3 uc008aoi.4 
ENSMUST00000014920.8 Nol3 ENSMUST00000014920.8 nucleolar protein 3 (apoptosis repressor with CARD domain) (from RefSeq NM_030152.4) Arc ENSMUST00000014920.1 ENSMUST00000014920.2 ENSMUST00000014920.3 ENSMUST00000014920.4 ENSMUST00000014920.5 ENSMUST00000014920.6 ENSMUST00000014920.7 NM_030152 NOL3_MOUSE Q9D1X0 uc009ncd.1 uc009ncd.2 uc009ncd.3 Apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:16505176) (PubMed:24312627). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (By similarity). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (PubMed:24440909). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (PubMed:22082675). Inhibits too myoblast differentiation through caspase inhibition (By similarity). Oligomerizes (via CARD doamin) (By similarity). Interacts (via CARD domain) with CASP2; inhibits CASP2 activity in a phosphorylation- dependent manner (By similarity). Interacts with CASP8; decreases CASP8 activity in a mitochondria localization- and phosphorylation-dependent manner and this interaction is dissociated by calcium. Interacts with TFPT; translocates NOL3 into the nucleus and negatively regulated TFPT- induced cell death (By similarity). Interacts directly (via CARD domain) with FAS and FADD (via DED domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS- FADD binding induced by FAS activation. Interacts (via CARD domain) with BAX (via a C-terminal 33 residues); inhibits BAX activation and translocation and consequently cytochrome c release from mitochondria. Interacts with PPM1G; may dephosphorylate NOL3 (By similarity). Interacts (via CARD domain) with BBC3 (via BH3 domain); preventing the association of BBC3 with BCL2 and resulting in activation of CASP8 (By similarity). Interacts (via CARD domain) with BAD(via BH3 domain); preventing the association of BAD with BCL2 (By similarity). Interacts directly (via CARD domain) with TNFRSF1A; inhibits TNF-signaling pathway. Q9D1X0; Q6PFR5: Tra2a; NbExp=4; IntAct=EBI-913097, EBI-913075; Cytoplasm tochondrion Sarcoplasmic reticulum Membrane ; Lipid-anchor Note=Phosphorylation at Thr-149 results in translocation to mitochondria. Colocalized with mitochondria in response to oxidative stress. CARD is critical for both extrinsic and intrinsic apoptotic pathways (By similarity). CARD domain mediates a protective effect against myocardial ischemia/reperfusion, oxidative stress and TNF- induced necrosis (PubMed:24440909). The C-terminal domain (amino acids 99 to 220) is involved in calcium binding and plays a protective role in calcium-mediated cell death (By similarity). Phosphorylation at Thr-149 is required for its antiapoptotic effect by blocking death-inducing signaling complex death-inducing signaling complex (DISC) activity through the control of interaction with CASP8. Phosphorylation at Thr-149 results in translocation to mitochondria and this translocation enables the binding to CASP8. Dephosphorylated at Thr-149 by calcineurin; doesn't inhibit the association between FADD and CASP8 and the consequent apoptosis. Polyubiquitinated by MDM2; promoting proteasomal-dependent degradation in response to apoptotic stimuli. Mice homozygous for the NOL3-null allele are born normally and externally indistinguishable from littermates of other genotypes. NOL3-null mice grew to adulthood without any abnormalities in their general health and appearance under resting conditions. Under biomechanical stress, NOL3-deficient mice develop accelerated cardiomyopathy which is characterized by reduced contractile function, cardiac enlargement, and myocardial fibrosis. Likewise, under ischemia/reperfusion injury of NOL3-deficient mice have a markedly increased myocardial infarct sizes (PubMed:16505176). Double homozygous knockout mice for NOL3 and SGCD have an enhanced myofiber death and subsequent dystrophic disease (PubMed:24312627). response to hypoxia blood vessel remodeling response to ischemia receptor binding death receptor binding calcium ion binding protein binding nucleolus cytoplasm mitochondrion mRNA splice site selection mRNA processing regulation of gene expression cardiac muscle cell apoptotic process negative regulation of striated muscle cell apoptotic process negative regulation of cardiac muscle cell apoptotic process negative regulation of tumor necrosis factor-mediated signaling pathway regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum negative regulation of muscle atrophy release of sequestered calcium ion into cytosol by sarcoplasmic reticulum response to injury involved in regulation of muscle adaptation membrane sarcoplasm sarcoplasmic reticulum kinase binding phosphatase binding death effector domain binding identical protein binding regulation of apoptotic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process myoblast differentiation metal ion binding smooth muscle cell proliferation protein oligomerization negative regulation of cytosolic calcium ion concentration negative regulation of mitochondrial calcium ion concentration negative regulation of necrotic cell death cellular response to hypoxia caspase binding negative regulation of release of cytochrome c from mitochondria intrinsic apoptotic signaling pathway inhibition of cysteine-type endopeptidase activity regulation of NIK/NF-kappaB signaling negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of mitochondrial membrane permeability involved in apoptotic process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of death-inducing signaling complex assembly negative regulation of hydrogen peroxide-induced cell death negative regulation of protein targeting to mitochondrion negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway inhibition of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of extrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway uc009ncd.1 uc009ncd.2 uc009ncd.3 
ENSMUST00000014922.5 Fhod1 ENSMUST00000014922.5 formin homology 2 domain containing 1 (from RefSeq NM_177699.4) ENSMUST00000014922.1 ENSMUST00000014922.2 ENSMUST00000014922.3 ENSMUST00000014922.4 FHOD1_MOUSE Fhos1 NM_177699 Q6P9Q4 Q8BMK2 uc009nct.1 uc009nct.2 uc009nct.3 uc009nct.4 Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing (By similarity). Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus (By similarity). Interacts with ROCK1 in a Src-dependent manner (By similarity). Cytoplasm Cytoplasm, cytosol Cytoplasm, cytoskeleton Cell projection, bleb Note=Predominantly cytoplasmic. Regulated by intramolecular binding to a C-terminal auto- inhibitory domain. Effector binding abolishes this interaction and activates the protein (By similarity). The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity). Phosphorylated by ROCK1. Belongs to the formin homology family. stress fiber molecular_function actin binding nucleus cytoplasm cytosol cytoskeleton nuclear migration intercalated disc protein domain specific binding bleb identical protein binding cell projection protein self-association positive regulation of transcription from RNA polymerase II promoter regulation of stress fiber assembly positive regulation of stress fiber assembly establishment of centrosome localization uc009nct.1 uc009nct.2 uc009nct.3 uc009nct.4 
ENSMUST00000014957.10 Stc1 ENSMUST00000014957.10 stanniocalcin 1 (from RefSeq NM_009285.3) ENSMUST00000014957.1 ENSMUST00000014957.2 ENSMUST00000014957.3 ENSMUST00000014957.4 ENSMUST00000014957.5 ENSMUST00000014957.6 ENSMUST00000014957.7 ENSMUST00000014957.8 ENSMUST00000014957.9 NM_009285 Q3UYZ1 Q3UYZ1_MOUSE Stc1 uc007ulz.1 uc007ulz.2 uc007ulz.3 Homodimer; disulfide-linked. Belongs to the stanniocalcin family. ossification endothelial cell morphogenesis growth plate cartilage axis specification hormone activity extracellular region nucleus cytoplasm cellular calcium ion homeostasis signal transduction embryo implantation negative regulation of endothelial cell migration response to organic cyclic compound apical plasma membrane negative regulation of cell migration response to vitamin D chondrocyte proliferation regulation of anion transport decidualization negative regulation of calcium ion transport bone development cellular response to cAMP cellular response to glucocorticoid stimulus cellular response to hypoxia regulation of cardiac muscle cell contraction positive regulation of calcium ion import negative regulation of renal phosphate excretion uc007ulz.1 uc007ulz.2 uc007ulz.3 
ENSMUST00000014981.8 Matcap1 ENSMUST00000014981.8 microtubule associated tyrosine carboxypeptidase 1, transcript variant 2 (from RefSeq NM_001166394.1) ENSMUST00000014981.1 ENSMUST00000014981.2 ENSMUST00000014981.3 ENSMUST00000014981.4 ENSMUST00000014981.5 ENSMUST00000014981.6 ENSMUST00000014981.7 MACAP_MOUSE Matcap NM_001166394 Q810A5 Q9D4J6 uc009ncg.1 uc009ncg.2 uc009ncg.3 uc009ncg.4 Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:35482892). Also able to remove the C- terminal phenylalanine residue of alpha-tubulin TUBA8. Recognizes adjacent tubulin dimers along the same protofilament (By similarity). Reaction=C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl- [tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl- [tubulin] + L-tyrosine; Xref=Rhea:RHEA:57444, Rhea:RHEA-COMP:16434, Rhea:RHEA-COMP:16435, ChEBI:CHEBI:15377, ChEBI:CHEBI:58315, ChEBI:CHEBI:149554, ChEBI:CHEBI:149555; EC=3.4.17.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57445; Evidence=; Reaction=C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L- phenylalanyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L- glutamyl-L-glutamyl-[tubulin] + L-phenylalanine; Xref=Rhea:RHEA:72663, Rhea:RHEA-COMP:16435, Rhea:RHEA-COMP:18133, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:149555, ChEBI:CHEBI:192362; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72664; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Cytoplasm, cytoskeleton Note=Associates with microtubules. Metalloprotease with an atypical HExxxH zinc-binding motif instead of HExxH, which interrupts the active site-containing helix without affecting the integrity of the catalytic site arrangement. The N-terminal disordered region enhances its anchoring on microtubules, while dampening processivity on the polymerized substrate. No visible phenotype: mice are viable and fertile and display no gross alterations (PubMed:35482892). Mice lacking both Matcap and Svbp are viable but show a reduction in brain volume: microcephaly is associated with proliferative defects during neurogenesis and abnormal behavior (PubMed:35482892). Cells lacking both Matcap and Svbp show abolished tubulin detyrosination (PubMed:35482892). Belongs to the peptidase MATCAP family. molecular_function cellular_component biological_process uc009ncg.1 uc009ncg.2 uc009ncg.3 uc009ncg.4 
ENSMUST00000014990.13 Tppp3 ENSMUST00000014990.13 tubulin polymerization-promoting protein family member 3 (from RefSeq NM_026481.3) ENSMUST00000014990.1 ENSMUST00000014990.10 ENSMUST00000014990.11 ENSMUST00000014990.12 ENSMUST00000014990.2 ENSMUST00000014990.3 ENSMUST00000014990.4 ENSMUST00000014990.5 ENSMUST00000014990.6 ENSMUST00000014990.7 ENSMUST00000014990.8 ENSMUST00000014990.9 NM_026481 Q3TUZ0 Q9CRB6 TPPP3_MOUSE Tppp3 uc009ndc.1 uc009ndc.2 uc009ndc.3 uc009ndc.4 Regulator of microtubule dynamic that has microtubule bundling activity (By similarity). Required for embryo implantation; possibly by regulating beta-catenin (PubMed:29901777). Also required for decidualization via regulation of beta-catenin (PubMed:30667362). Cytoplasm Cytoplasm, cytoskeleton Expressed in the connective tissues of differentiating tendons and synovial joints (PubMed:19235716). Expressed in the uterus during window of implantation and early pregnancy (at protein level) (PubMed:29901777). Up-regulated by estradiol. Belongs to the TPPP family. microtubule bundle formation cytoplasm cytoskeleton microtubule tubulin binding positive regulation of protein polymerization microtubule polymerization perinuclear region of cytoplasm microtubule bundle uc009ndc.1 uc009ndc.2 uc009ndc.3 uc009ndc.4 
ENSMUST00000015000.12 Tmem208 ENSMUST00000015000.12 transmembrane protein 208, transcript variant 3 (from RefSeq NM_025486.3) ENSMUST00000015000.1 ENSMUST00000015000.10 ENSMUST00000015000.11 ENSMUST00000015000.2 ENSMUST00000015000.3 ENSMUST00000015000.4 ENSMUST00000015000.5 ENSMUST00000015000.6 ENSMUST00000015000.7 ENSMUST00000015000.8 ENSMUST00000015000.9 NM_025486 Q3V2H5 Q8R1F8 Q9CR96 TM208_MOUSE uc009ncs.1 uc009ncs.2 uc009ncs.3 uc009ncs.4 May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CR96-1; Sequence=Displayed; Name=2; IsoId=Q9CR96-2; Sequence=VSP_032506; Belongs to the TMEM208 family. molecular_function vacuole endoplasmic reticulum endoplasmic reticulum membrane vacuolar protein processing autophagy membrane integral component of membrane uc009ncs.1 uc009ncs.2 uc009ncs.3 uc009ncs.4 
ENSMUST00000015003.10 E2f4 ENSMUST00000015003.10 E2F transcription factor 4 (from RefSeq NM_148952.1) E2F4_MOUSE ENSMUST00000015003.1 ENSMUST00000015003.2 ENSMUST00000015003.3 ENSMUST00000015003.4 ENSMUST00000015003.5 ENSMUST00000015003.6 ENSMUST00000015003.7 ENSMUST00000015003.8 ENSMUST00000015003.9 NM_148952 Q8R0K9 Q8R2X6 uc009ncl.1 uc009ncl.2 Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with TFDP1/Dp-1 to E2F sites. The E2F4/TFDP1 dimer interacts preferentially with pocket protein RBL1, which inhibits the E2F transactivation domain. Lower affinity interaction has been found with retinoblastoma protein RB1. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Interacts with HCFC1. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with PML. Interacts with CEBPA (when phosphorylated) (By similarity). Nucleus Differentially phosphorylated in vivo. Postnatal lethality, probably due to the absence of ciliated cells from the entire airway epithelium and the epithelium of the submucosal glands in the paranasal sinuses. In the nasal epithelium, ciliated cells are replaced by columnar secretory cells that produce mucin-like substances. In the proximal lung, reduction in club cells is also observed. The combination of no ciliated cells and excess mucous cells leads for the chronic rhinitis and increased susceptibility to opportunistic infections that cause lethality. Belongs to the E2F/DP family. regulation of transcription involved in G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter mitotic cell cycle nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding epithelial cell development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm regulation of transcription, DNA-templated cell volume homeostasis cell cycle blood circulation transcription factor binding regulation of cell size animal organ morphogenesis protein domain specific binding cell projection organization regulation of cell proliferation sequence-specific DNA binding motile cilium assembly positive regulation of transcription from RNA polymerase II promoter protein dimerization activity regulation of cell cycle cilium assembly RNA polymerase II transcription factor complex centriole assembly multi-ciliated epithelial cell differentiation promoter-specific chromatin binding uc009ncl.1 uc009ncl.2 
ENSMUST00000015011.10 Surf4 ENSMUST00000015011.10 surfeit gene 4, transcript variant 5 (from RefSeq NR_185258.1) ENSMUST00000015011.1 ENSMUST00000015011.2 ENSMUST00000015011.3 ENSMUST00000015011.4 ENSMUST00000015011.5 ENSMUST00000015011.6 ENSMUST00000015011.7 ENSMUST00000015011.8 ENSMUST00000015011.9 NR_185258 Q64310 SURF4_MOUSE Surf-4 Surf4 uc008iwl.1 uc008iwl.2 uc008iwl.3 uc008iwl.4 Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis. Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins. Promotes the secretion of PCSK9. Also mediates the efficient secretion of erythropoietin (EPO). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Found in a complex composed at least of SURF4, TMED2 and TMED10 (By similarity). May interact with LMAN1 (By similarity). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701). Interacts with STING1 (By similarity). Interacts with SAR1B (By similarity). Interacts with TMEM41B (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Note=Cycles between the endoplasmic reticulum and the Golgi. The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins. Embryonic lethality between 3.5 and 9.5 dpc (PubMed:31978056). Conditional deletion in the liver depletes plasma lipids and protects mice from atherosclerosis (PubMed:33186557). Belongs to the SURF4 family. Golgi membrane protein binding endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus Golgi organization positive regulation of organelle organization membrane integral component of membrane endoplasmic reticulum-Golgi intermediate compartment membrane uc008iwl.1 uc008iwl.2 uc008iwl.3 uc008iwl.4 
ENSMUST00000015017.8 Surf2 ENSMUST00000015017.8 surfeit gene 2, transcript variant 12 (from RefSeq NR_185256.1) ENSMUST00000015017.1 ENSMUST00000015017.2 ENSMUST00000015017.3 ENSMUST00000015017.4 ENSMUST00000015017.5 ENSMUST00000015017.6 ENSMUST00000015017.7 NR_185256 Q4VAF7 Q4VAF7_MOUSE Surf2 uc008iwj.1 uc008iwj.2 uc008iwj.3 uc008iwj.4 nucleus nucleolus plasma membrane nuclear speck uc008iwj.1 uc008iwj.2 uc008iwj.3 uc008iwj.4 
ENSMUST00000015049.5 Dnajb9 ENSMUST00000015049.5 DnaJ heat shock protein family (Hsp40) member B9 (from RefSeq NM_013760.4) DNJB9_MOUSE Dnajb9 ENSMUST00000015049.1 ENSMUST00000015049.2 ENSMUST00000015049.3 ENSMUST00000015049.4 NM_013760 Q5D0C3 Q9DAW1 Q9QYI6 uc007nlo.1 uc007nlo.2 uc007nlo.3 Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:11836248). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:22267725). Required for survival of B-cell progenitors and normal antibody production (PubMed:25222125). Interacts with HSPA5/BiP; interaction is direct (PubMed:11836248). Interacts with ERN1/IRE1 (via the luminal region) (By similarity). Interacts with DERL1 (PubMed:22267725). Endoplasmic reticulum lumen The J domain stimulates the ATPase activity of HSPA5/BiP, while the divergent targeting domain is required for efficient substrate recognition by HSPA5/BiP. The divergent targeting domain specifically recognizes and binds to aggregation-prone sequences. Not N-glycosylated. Perinatal death in approximately half of knockout mice (PubMed:24336520). Death is caused by fetal growth restriction, reduced hepatic glycogen stores and hypoglycemia (PubMed:24336520). Surviving adult mice display constitutive endoplasmic reticulum stress in multiple cells and tissues (PubMed:24336520). Elevated endoplasmic reticulum stress in pancreatic beta cells is associated with beta cell loss, hypoinsulinemia and glucose intolerance (PubMed:24336520) Conditional knockout mice lacking Dnajb9 in bone marrow show impaired hematopoiesis: the number of myeloid cells is increased, while the number of erythroid and B lymphoid cells is reduced (PubMed:25222125). B-cell defects cause decreased survival of B-cell precursors, including large and small pre-B, and immature B-cells (PubMed:25222125). Was initially thought to be an integral membrane protein (PubMed:11836248). However, it was later shown that it is a soluble luminal protein localized in the endoplasmic reticulum lumen. immunoglobulin production protein binding nucleolus cytoplasm endoplasmic reticulum endoplasmic reticulum lumen response to unfolded protein B cell differentiation ER-associated ubiquitin-dependent protein catabolic process Hsp70 protein binding response to endoplasmic reticulum stress chaperone binding misfolded protein binding negative regulation of IRE1-mediated unfolded protein response uc007nlo.1 uc007nlo.2 uc007nlo.3 
ENSMUST00000015100.15 Ppp1cb ENSMUST00000015100.15 protein phosphatase 1 catalytic subunit beta (from RefSeq NM_172707.3) ENSMUST00000015100.1 ENSMUST00000015100.10 ENSMUST00000015100.11 ENSMUST00000015100.12 ENSMUST00000015100.13 ENSMUST00000015100.14 ENSMUST00000015100.2 ENSMUST00000015100.3 ENSMUST00000015100.4 ENSMUST00000015100.5 ENSMUST00000015100.6 ENSMUST00000015100.7 ENSMUST00000015100.8 ENSMUST00000015100.9 NM_172707 P37140 P62141 PP1B_MOUSE Q3TBE5 Q3TL90 Q542E7 Q8C285 Q9DBY2 uc008wzq.1 uc008wzq.2 uc008wzq.3 uc008wzq.4 Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Reaction=H2O + O-phospho-L-seryl-[myosin light chain] = L-seryl-[myosin light chain] + phosphate; Xref=Rhea:RHEA:12849, Rhea:RHEA-COMP:13684, Rhea:RHEA-COMP:13685, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.53; Reaction=H2O + O-phospho-L-threonyl-[myosin light chain] = L-threonyl- [myosin light chain] + phosphate; Xref=Rhea:RHEA:53988, Rhea:RHEA- COMP:13686, Rhea:RHEA-COMP:13687, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.53; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress (By similarity). PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. The targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with PPP1R7 and PPP1R12C. Interacts with PPP1R12A and NUAK1; the interaction is direct. Interacts with TRIM28; the interaction is weak (By similarity). Interacts with PPP1R15A; the interaction mediates binding to EIF2S1. Interacts with PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with TRIM28; the interaction is weak (By similarity). Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PPP1R15B; the interaction mediates binding to EIF2S1. Interacts with FOXP3 (By similarity). Interacts with RRP1B (By similarity). Interacts with SERPINE1. Interacts with LZTR1 (By similarity). Cytoplasm Nucleus Nucleus, nucleoplasm Nucleus, nucleolus Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. Belongs to the PPP phosphatase family. PP-1 subfamily. Name=Protein Spotlight; Note=The things we forget - Issue 32 of March 2003; URL="https://web.expasy.org/spotlight/back_issues/032"; protein phosphatase type 1 complex nuclear chromosome, telomeric region phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol plasma membrane carbohydrate metabolic process glycogen metabolic process regulation of glycogen biosynthetic process regulation of glycogen catabolic process protein dephosphorylation cell cycle hydrolase activity phosphatase activity myosin phosphatase activity protein kinase binding regulation of cell adhesion circadian regulation of gene expression glycogen granule regulation of circadian rhythm entrainment of circadian clock by photoperiod metal ion binding rhythmic process myosin-light-chain-phosphatase activity cell division PTW/PP1 phosphatase complex uc008wzq.1 uc008wzq.2 uc008wzq.3 uc008wzq.4 
ENSMUST00000015124.15 Tsen15 ENSMUST00000015124.15 tRNA splicing endonuclease subunit 15 (from RefSeq NM_025677.3) ENSMUST00000015124.1 ENSMUST00000015124.10 ENSMUST00000015124.11 ENSMUST00000015124.12 ENSMUST00000015124.13 ENSMUST00000015124.14 ENSMUST00000015124.2 ENSMUST00000015124.3 ENSMUST00000015124.4 ENSMUST00000015124.5 ENSMUST00000015124.6 ENSMUST00000015124.7 ENSMUST00000015124.8 ENSMUST00000015124.9 G3X8S8 G3X8S8_MOUSE NM_025677 Tsen15 uc007czf.1 uc007czf.2 uc007czf.3 uc007czf.4 Belongs to the SEN15 family. tRNA-intron endonuclease activity nucleic acid binding nuclease activity tRNA splicing, via endonucleolytic cleavage and ligation nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc007czf.1 uc007czf.2 uc007czf.3 uc007czf.4 
ENSMUST00000015137.10 Limk1 ENSMUST00000015137.10 LIM domain kinase 1, transcript variant 1 (from RefSeq NM_010717.3) ENSMUST00000015137.1 ENSMUST00000015137.2 ENSMUST00000015137.3 ENSMUST00000015137.4 ENSMUST00000015137.5 ENSMUST00000015137.6 ENSMUST00000015137.7 ENSMUST00000015137.8 ENSMUST00000015137.9 LIMK1_MOUSE Limk NM_010717 P53668 uc008zwt.1 uc008zwt.2 uc008zwt.3 This gene encodes a member of the LIM kinase family of proteins. This protein is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein also stimulates axon growth and may play a role in brain development. Homozygous knockout mice for this gene exhibit reduced bone mass, abnormal neuronal morphology and altered synaptic function. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:15056216, PubMed:16204183). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:15056216). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Self-associates to form homodimers. Interacts with HSP90AA1; this interaction promotes LIMK1 dimerization and subsequent transphosphorylation. Interacts with CDKN1C (By similarity). Interacts (via LIM domain) with the cytoplasmic domain of NRG1 (By similarity). Interacts with NISCH (PubMed:18332102). Interacts with SSH1 (PubMed:15660133). Interacts with RLIM and RNF6 (PubMed:16204183). Interacts (via LIM zinc-binding domains) with FAM89B/LRAP25 (via LRR repeat). Forms a tripartite complex with CDC42BPA, CDC42BPB and FAM89B/LRAP25 (PubMed:25107909). Cytoplasm Nucleus Cytoplasm, cytoskeleton Cell projection, lamellipodium Note=Predominantly found in the cytoplasm (By similarity). Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B/LRAP25-dependent manner. Highest expression in the nervous system, particularly in the spinal cord and the cranial nerve and dorsal root ganglia. Expressed in ventral neural tube and axonal projections at 12.5 dpc-13 dpc (at protein level). Autophosphorylated. Phosphorylated on Thr-508 by ROCK1 and PAK1, resulting in activation. Phosphorylated by PAK4 which increases the ability of LIMK1 to phosphorylate cofilin. Phosphorylated at Ser-323 by MAPKAPK2 during activation of VEGFA-induced signaling, which results in activation of LIMK1 and promotion of actin reorganization, cell migration, and tubule formation of endothelial cells. Dephosphorylated and inactivated by SSH1. Phosphorylated by CDC42BP (By similarity). Ubiquitinated. 'Lys-48'-linked polyubiquitination by RNF6 leads to proteasomal degradation through the 26S proteasome, modulating LIMK1 levels in the growth cone and its effect on axonal outgrowth. Also polyubiquitinated by RLIM. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm Golgi apparatus cytosol focal adhesion protein phosphorylation membrane kinase activity phosphorylation nuclear speck transferase activity lamellipodium actin cytoskeleton organization heat shock protein binding positive regulation of actin filament bundle assembly cell projection neuron projection axonal growth cone positive regulation of axon extension metal ion binding protein heterodimerization activity perinuclear region of cytoplasm negative regulation of ubiquitin-protein transferase activity positive regulation of stress fiber assembly uc008zwt.1 uc008zwt.2 uc008zwt.3 
ENSMUST00000015138.13 Eln ENSMUST00000015138.13 elastin (from RefSeq NM_007925.4) ELN_MOUSE ENSMUST00000015138.1 ENSMUST00000015138.10 ENSMUST00000015138.11 ENSMUST00000015138.12 ENSMUST00000015138.2 ENSMUST00000015138.3 ENSMUST00000015138.4 ENSMUST00000015138.5 ENSMUST00000015138.6 ENSMUST00000015138.7 ENSMUST00000015138.8 ENSMUST00000015138.9 NM_007925 P54320 Q8C9L8 uc008zwv.1 uc008zwv.2 uc008zwv.3 uc008zwv.4 This gene encodes elastin, the extracellular matrix protein that forms a major structural component of several tissues including lungs and arterial walls. Cleavage of the signal peptide from the encoded precursor generates soluble tropoelastin which undergoes lysine-derived crosslinking to form elastin polymers. Mice lacking the encoded protein exhibit defective lung development, and die of an obstructive arterial disease resulting from subendothelial cell proliferation and reorganization of smooth muscle. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051649.1, AK041860.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. The polymeric elastin chains are cross-linked together into an extensible 3D network. Forms a ternary complex with BGN and MFAP2. Interacts with MFAP2 via divalent cations (calcium > magnesium > manganese) in a dose-dependent and saturating manner. Interacts with FBLN5 and FBN1. Forms a ternary complex with FBN1 and FBLN2 or FBLN5. Interacts with MFAP4 in a Ca (2+)-dependent manner; this interaction promotes ELN self-assembly (By similarity). Interacts with EFEMP2 with moderate affinity (By similarity). Secreted, extracellular space, extracellular matrix Note=Extracellular matrix of elastic fibers. Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross- links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4- hydroxylation in vertebrates. Belongs to the elastin family. outflow tract morphogenesis extracellular matrix structural constituent protein binding extracellular region mitochondrion skeletal muscle tissue development extracellular matrix constituent conferring elasticity extracellular matrix organization regulation of actin filament polymerization stress fiber assembly extracellular matrix binding elastic fiber uc008zwv.1 uc008zwv.2 uc008zwv.3 uc008zwv.4 
ENSMUST00000015146.16 Efr3a ENSMUST00000015146.16 EFR3 homolog A, transcript variant 1 (from RefSeq NM_133766.4) EFR3A_MOUSE ENSMUST00000015146.1 ENSMUST00000015146.10 ENSMUST00000015146.11 ENSMUST00000015146.12 ENSMUST00000015146.13 ENSMUST00000015146.14 ENSMUST00000015146.15 ENSMUST00000015146.2 ENSMUST00000015146.3 ENSMUST00000015146.4 ENSMUST00000015146.5 ENSMUST00000015146.6 ENSMUST00000015146.7 ENSMUST00000015146.8 ENSMUST00000015146.9 Efr3a Kiaa0143 NM_133766 Q6ZQI4 Q8BG67 Q8BXQ7 Q8C0Q0 Q922I2 uc007vzu.1 uc007vzu.2 uc007vzu.3 Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3A probably acts as the membrane-anchoring component. Also involved in responsiveness to G- protein-coupled receptors; it is however unclear whether this role is direct or indirect. Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2). Cell membrane ; Lipid-anchor Cytoplasm, cytosol Note=Palmitoylation anchors the protein to the plasma membrane. A small amount is observed in the cytosol. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BG67-1; Sequence=Displayed; Name=2; IsoId=Q8BG67-2; Sequence=VSP_022219; Widely expressed (PubMed:25380825). Expressed in neurons of the superior olivary complex of the auditory brainstem. Also expressed at lower levels in the cochlear nucleus, the lateral leminiscal nuclei and the inferior collicus (PubMed:15363888). Expression is reduced in animals with impaired hearing. Palmitoylated at its N-terminus, anchoring the protein to the plasma membrane. Belongs to the EFR3 family. Sequence=BAC97875.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cornified envelope cytoplasm cytosol plasma membrane membrane protein homodimerization activity protein localization to plasma membrane cell-cell adhesion uc007vzu.1 uc007vzu.2 uc007vzu.3 
ENSMUST00000015157.10 Trappc2l ENSMUST00000015157.10 trafficking protein particle complex 2L (from RefSeq NM_021502.2) A4FUI9 ENSMUST00000015157.1 ENSMUST00000015157.2 ENSMUST00000015157.3 ENSMUST00000015157.4 ENSMUST00000015157.5 ENSMUST00000015157.6 ENSMUST00000015157.7 ENSMUST00000015157.8 ENSMUST00000015157.9 NM_021502 Q9JME7 TPC2L_MOUSE uc009ntj.1 uc009ntj.2 uc009ntj.3 uc009ntj.4 May play a role in vesicular transport from endoplasmic reticulum to Golgi. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with the heterodimer TRAPPC3-TRAPPC6A (By similarity). Cytoplasm, perinuclear region Endoplasmic reticulum Golgi apparatus Belongs to the TRAPP small subunits family. Sedlin subfamily. Sequence=AAI14969.1; Type=Erroneous initiation; Evidence=; cytoplasm endoplasmic reticulum Golgi apparatus cytosol ER to Golgi vesicle-mediated transport vesicle-mediated transport TRAPP complex intracellular membrane-bounded organelle perinuclear region of cytoplasm protein oligomerization uc009ntj.1 uc009ntj.2 uc009ntj.3 uc009ntj.4 
ENSMUST00000015160.6 Acsf3 ENSMUST00000015160.6 acyl-CoA synthetase family member 3 (from RefSeq NM_144932.4) ACSF3_MOUSE Acsf3 ENSMUST00000015160.1 ENSMUST00000015160.2 ENSMUST00000015160.3 ENSMUST00000015160.4 ENSMUST00000015160.5 NM_144932 Q3URE1 Q78IW2 Q8VC75 uc009ntt.1 uc009ntt.2 uc009ntt.3 Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates. Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616, ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640; Evidence=; Reaction=ATP + CoA + malonate = AMP + diphosphate + malonyl-CoA; Xref=Rhea:RHEA:32139, ChEBI:CHEBI:15792, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:456215; EC=6.2.1.76; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32140; Evidence=; Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3URE1-1; Sequence=Displayed; Name=2; IsoId=Q3URE1-2; Sequence=VSP_030705, VSP_030706; Belongs to the ATP-dependent AMP-binding enzyme family. Sequence=AAH22709.3; Type=Erroneous initiation; Evidence=; nucleotide binding catalytic activity ATP binding mitochondrion lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process ligase activity acid-thiol ligase activity very long-chain fatty acid-CoA ligase activity malonyl-CoA synthetase activity malonate catabolic process uc009ntt.1 uc009ntt.2 uc009ntt.3 
ENSMUST00000015171.11 Galns ENSMUST00000015171.11 galactosamine (N-acetyl)-6-sulfatase, transcript variant 1 (from RefSeq NM_016722.4) ENSMUST00000015171.1 ENSMUST00000015171.10 ENSMUST00000015171.2 ENSMUST00000015171.3 ENSMUST00000015171.4 ENSMUST00000015171.5 ENSMUST00000015171.6 ENSMUST00000015171.7 ENSMUST00000015171.8 ENSMUST00000015171.9 GALNS_MOUSE NM_016722 Q3TWQ4 Q571E4 Q99KU8 Q9JHK9 uc012gmh.1 uc012gmh.2 uc012gmh.3 Reaction=Hydrolysis of the 6-sulfate groups of the N-acetyl-D- galactosamine 6-sulfate units of chondroitin sulfate and of the D- galactose 6-sulfate units of keratan sulfate.; EC=3.1.6.4; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Homodimer. Lysosome Widely expressed. Higher expression in liver and kidney. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. Belongs to the sulfatase family. Sequence=BAD90170.1; Type=Erroneous initiation; Evidence=; catalytic activity arylsulfatase activity lysosome sulfuric ester hydrolase activity hydrolase activity N-acetylgalactosamine-6-sulfatase activity metal ion binding uc012gmh.1 uc012gmh.2 uc012gmh.3 
ENSMUST00000015236.4 Edf1 ENSMUST00000015236.4 endothelial differentiation-related factor 1 (from RefSeq NM_021519.2) EDF1_MOUSE ENSMUST00000015236.1 ENSMUST00000015236.2 ENSMUST00000015236.3 NM_021519 Q99NE6 Q9JMG1 uc008isn.1 uc008isn.2 uc008isn.3 Transcriptional coactivator stimulating NR5A1 and ligand- dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism (By similarity). Interacts with TBP and the transcription factor IID (TFIID) complex, NR5A2, NR1H3 and PPARG. Interaction with TBP is regulated by phosphorylation. Binds NR5A1, ATF1, FOS and JUN via their conserved basic region. Binding to calmodulin is regulated by calcium and phosphorylation of the IQ motif (By similarity). Cytoplasm Nucleus Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin. Expressed in brain, liver, kidney and heart (at protein level). Also expressed in testis. Very highly expressed seven days after implantation, when gastrulation and neurulation occurs. Expression decreases 11 days after implantation, when organogenesis is being completed, and remains rather low up to late developmental stages. The IQ motif, which is involved in calmodulin binding, overlaps with the binding domain for nuclear receptors and transcription factors. Its phosphorylation probably allows a switch between the two activities of the protein (By similarity). Phosphorylated. TFIID-class transcription factor binding DNA binding transcription coactivator activity calmodulin binding nucleus nucleolus cytoplasm cytosol multicellular organism development cell differentiation positive regulation of DNA binding positive regulation of nucleic acid-templated transcription uc008isn.1 uc008isn.2 uc008isn.3 
ENSMUST00000015239.10 Fbxw5 ENSMUST00000015239.10 F-box and WD-40 domain protein 5, transcript variant 1 (from RefSeq NM_013908.5) A2AJ36 A2AJ37 E9QMP0 ENSMUST00000015239.1 ENSMUST00000015239.2 ENSMUST00000015239.3 ENSMUST00000015239.4 ENSMUST00000015239.5 ENSMUST00000015239.6 ENSMUST00000015239.7 ENSMUST00000015239.8 ENSMUST00000015239.9 FBXW5_MOUSE Fbw5 NM_013908 Q3U368 Q9QXW2 uc008isj.1 uc008isj.2 uc008isj.3 Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin- protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication (By similarity). The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Protein modification; protein ubiquitination. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXW5) composed of CUL1, SKP1, RBX1 and FBXW5. Component of the DCX(FBXW5) E3 ubiquitin ligase complex, at least composed of (CUL4A or CUL4B), DDB1, FBXW5 and RBX1. Interacts with CDC20, TSC1, TSC2 and SASS6 (By similarity). Interacts with EPS8. Interacts with TNFAIP8L1; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination. Q9QXW2; Q9WTX5: Skp1; NbExp=2; IntAct=EBI-16031930, EBI-1202363; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QXW2-1; Sequence=Displayed; Name=2; IsoId=Q9QXW2-2; Sequence=VSP_042293, VSP_042294; Widely expressed in adult and embryonal tissues. The F-box domain mediates interaction with components of SCF (SKP1-CUL1-F-box protein) complexes, while WD repeats mediate interaction with components of DCX (DDB1-CUL4-X-box) complexes. The D-box (destruction box) mediate the interaction with APC proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway. Phosphorylated at Ser-151 by PLK4 during the G1/S transition, leading to inhibit its ability to ubiquitinate SASS6. Ubiquitinated and degraded by the APC/C complex during mitosis and G1 phase. Belongs to the FBXW5 family. Sequence=CAM25630.1; Type=Erroneous gene model prediction; Evidence=; protein binding cytoplasm regulation of mitotic nuclear division regulation of centrosome duplication protein ubiquitination SCF ubiquitin ligase complex protein kinase binding SCF-dependent proteasomal ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process Cul4-RING E3 ubiquitin ligase complex uc008isj.1 uc008isj.2 uc008isj.3 
ENSMUST00000015267.6 Prss28 ENSMUST00000015267.6 serine protease 28 (from RefSeq NM_053259.2) A0A0R4IZZ8 A0A0R4IZZ8_MOUSE ENSMUST00000015267.1 ENSMUST00000015267.2 ENSMUST00000015267.3 ENSMUST00000015267.4 ENSMUST00000015267.5 NM_053259 Prss28 uc008ban.1 uc008ban.2 uc008ban.3 Belongs to the peptidase S1 family. CLIP subfamily. serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc008ban.1 uc008ban.2 uc008ban.3 
ENSMUST00000015277.14 Lrrk1 ENSMUST00000015277.14 leucine-rich repeat kinase 1 (from RefSeq NM_146191.3) ENSMUST00000015277.1 ENSMUST00000015277.10 ENSMUST00000015277.11 ENSMUST00000015277.12 ENSMUST00000015277.13 ENSMUST00000015277.2 ENSMUST00000015277.3 ENSMUST00000015277.4 ENSMUST00000015277.5 ENSMUST00000015277.6 ENSMUST00000015277.7 ENSMUST00000015277.8 ENSMUST00000015277.9 Kiaa1790 LRRK1_MOUSE Lrrk1 NM_146191 Q3U476 Q3UHC2 Q66JQ4 Q6GQR9 Q6NZF5 Q6ZPI4 Q8BKP3 Q8BU93 Q8BUY0 Q8BVV2 Q8R085 uc009hhd.1 uc009hhd.2 uc009hhd.3 uc009hhd.4 Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Binding of GTP stimulates kinase activity. Homodimer (By similarity). Interacts with CSK (PubMed:23526378). Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q3UHC2-1; Sequence=Displayed; Name=2 ; IsoId=Q3UHC2-2; Sequence=VSP_052014; Name=3 ; IsoId=Q3UHC2-3; Sequence=VSP_052013, VSP_052015, VSP_052016; Expressed in osteoclasts and bone marrow stromal cells. Knockout mice are born at the expected Mendelian ratio. At 4 weeks of age, their body length is slightly shorter than that of wild-type littermates. They progressively develop severe osteopetrosis, reduced bone resorption in endocortical and trabecular regions, and increased bone mineralization. Knockout animals have lifelong accumulation of bone, and females are resistant to ovariectomy-induced bone loss. Osteoclasts derived from mutant mice form a reduced area of resorption pits compared to controls, suggesting dysfunction of multinucleated osteoclasts. Osteoclast precursors differentiate into multinucleated cells, but fail to form peripheral sealing zones and ruffled borders, and do not resorb bone (PubMed:23526378, PubMed:27055475). These abnormalities are associated with changes in the SRC signaling pathway. This phenotype may be specific LRRK1 ablation, as knockout of the paralogous gene LRRK2 does not show any obvious bone phenotype (PubMed:23526378). Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. Sequence=AAH27199.1; Type=Erroneous initiation; Evidence=; Sequence=BAC36341.1; Type=Erroneous initiation; Evidence=; Sequence=BAC39743.1; Type=Erroneous initiation; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding GTP binding cytoplasm mitochondrion cytosol protein phosphorylation kinase activity phosphorylation transferase activity osteoclast development identical protein binding bone resorption metal ion binding positive regulation of peptidyl-tyrosine phosphorylation negative regulation of peptidyl-tyrosine phosphorylation positive regulation of canonical Wnt signaling pathway positive regulation of intracellular signal transduction uc009hhd.1 uc009hhd.2 uc009hhd.3 uc009hhd.4 
ENSMUST00000015278.15 Aldh1a3 ENSMUST00000015278.15 aldehyde dehydrogenase family 1, subfamily A3 (from RefSeq NM_053080.3) AL1A3_MOUSE Aldh6 ENSMUST00000015278.1 ENSMUST00000015278.10 ENSMUST00000015278.11 ENSMUST00000015278.12 ENSMUST00000015278.13 ENSMUST00000015278.14 ENSMUST00000015278.2 ENSMUST00000015278.3 ENSMUST00000015278.4 ENSMUST00000015278.5 ENSMUST00000015278.6 ENSMUST00000015278.7 ENSMUST00000015278.8 ENSMUST00000015278.9 NM_053080 Q9EQP7 Q9JHW9 Q9JI72 Raldh3 uc009hhi.1 uc009hhi.2 uc009hhi.3 uc009hhi.4 uc009hhi.5 Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans- 13,14-dihydroretinoate, respectively (PubMed:11013254, PubMed:11044606, PubMed:14623956, PubMed:15911617). High specificity for all-trans- retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (By similarity). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (PubMed:14623956). Reaction=H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate; Xref=Rhea:RHEA:16177, ChEBI:CHEBI:15035, ChEBI:CHEBI:15036, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.36; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16178; Evidence=; Reaction=all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:42080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.36; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42081; Evidence= Reaction=all-trans-13,14-dihydroretinal + H2O + NAD(+) = all-trans- 13,14-dihydroretinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:75119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:194182, ChEBI:CHEBI:194183; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75120; Evidence=; Kinetic parameters: KM=0.33 uM for all-trans retinal ; Vmax=58 nmol/min/mg enzyme for all-trans retinal ; Cofactor metabolism; retinol metabolism. Homotetramer. Cytoplasm Detected in embryonic head (at protein level) (PubMed:14623956). Ventral retina. In mouse embryos, RALDH3 expression is first noticed in the ventral optic eminence at 8.75 dpc, then in the optic vesicle/cup, otic vesicle and olfactory placode/pit from 9.5 dpc to 11.5 dpc. Mutant mice are born at the expected Mendelian rate, but all die within 10 hours after birth (PubMed:14623956, PubMed:23536097). Lethality is due to respiratory distress, caused by choanal atresia, i.e. the lack of communication between the nasal and oral cavities. Mutant embryos at 11.5 dpc lack detectable retinoic acid in the ventral retina, nasal epithelium and in the nasolacrimal groove. At 14.5 dpc mutant embryos display shortening of the ventral retina associated with lens rotation and persistence of the retrolenticular membrane, indicative of retinoic acid deficiency. Still, at 18.5 dpc the ventral retina appears normal. Embryos at 18.5 dpc lack Harderian glands, and display multiple malformations in the nasal region, including choanal atresia, lack of maxillary sinuses and nasolacrimal ducts (PubMed:14623956). Oral gavage of pregnant females with retinoic acid prevents choanal atresia and other malformations of the nasal region (PubMed:14623956, PubMed:23536097). Females that were fed retinoic acid give birth to pups with malformations of the inner ear vestibular organ, causing repetitive circling behavior with head tilting (PubMed:23536097). Likewise, mice display impaired ability in crossing a beam without slipping and an impaired ability to swim (PubMed:23536097). Belongs to the aldehyde dehydrogenase family. retinal dehydrogenase activity optic cup morphogenesis involved in camera-type eye development retinoic acid biosynthetic process 3-chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity aldehyde dehydrogenase [NAD(P)+] activity nucleus cytoplasm cytosol plasma membrane cellular aldehyde metabolic process locomotory behavior oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor nucleus accumbens development embryonic camera-type eye development inner ear morphogenesis retinol metabolic process retinoic acid metabolic process retinal metabolic process protein homodimerization activity positive regulation of apoptotic process nose development embryonic eye morphogenesis positive regulation of retinoic acid receptor signaling pathway neuromuscular process controlling balance protein homotetramerization oxidation-reduction process righting reflex olfactory pit development face development thyroid hormone binding Harderian gland development NAD+ binding uc009hhi.1 uc009hhi.2 uc009hhi.3 uc009hhi.4 uc009hhi.5 
ENSMUST00000015333.12 Casd1 ENSMUST00000015333.12 CAS1 domain containing 1, transcript variant 1 (from RefSeq NM_145398.4) CASD1_MOUSE Cas1 Casd1 Cast1 ENSMUST00000015333.1 ENSMUST00000015333.10 ENSMUST00000015333.11 ENSMUST00000015333.2 ENSMUST00000015333.3 ENSMUST00000015333.4 ENSMUST00000015333.5 ENSMUST00000015333.6 ENSMUST00000015333.7 ENSMUST00000015333.8 ENSMUST00000015333.9 NM_145398 Q1RN01 Q6PD39 Q7TN73 Q8VEF5 uc009avo.1 uc009avo.2 uc009avo.3 O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids. Sialic acids are sugars at the reducing end of glycoproteins and glycolipids, and are involved in various processes such as cell-cell interactions, host-pathogen recognition. Reaction=acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-9-O- acetylneuraminate; Xref=Rhea:RHEA:26043, ChEBI:CHEBI:28999, ChEBI:CHEBI:35418, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.45; Evidence=; Reaction=acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-7-O- acetylneuraminate; Xref=Rhea:RHEA:20808, ChEBI:CHEBI:28944, ChEBI:CHEBI:35418, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.45; Evidence=; Golgi apparatus membrane ; Multi-pass membrane protein Ubiquitously expressed. Expressed in neonatal brain and in day 10 and 13 embryo. N-glycosylated. The Casd1 locus is imprinted. Maternal inherited gene is expressed, while the paternal inherited gene is silenced. Belongs to the PC-esterase family. CASD1 subfamily. Sequence=AAH18542.1; Type=Erroneous initiation; Evidence=; Sequence=AAH38009.1; Type=Erroneous initiation; Evidence=; Golgi membrane protein binding Golgi apparatus carbohydrate metabolic process membrane integral component of membrane acetyltransferase activity transferase activity transferase activity, transferring acyl groups integral component of Golgi membrane N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity uc009avo.1 uc009avo.2 uc009avo.3 
ENSMUST00000015346.12 Cnksr3 ENSMUST00000015346.12 Cnksr family member 3 (from RefSeq NM_172546.2) CNKR3_MOUSE ENSMUST00000015346.1 ENSMUST00000015346.10 ENSMUST00000015346.11 ENSMUST00000015346.2 ENSMUST00000015346.3 ENSMUST00000015346.4 ENSMUST00000015346.5 ENSMUST00000015346.6 ENSMUST00000015346.7 ENSMUST00000015346.8 ENSMUST00000015346.9 NM_172546 Q3UDS2 Q8BMA3 Q8K2K0 uc007efb.1 uc007efb.2 uc007efb.3 Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC). Interacts with epithelial sodium channel ENaC. Interacts directly with SCNN1A (ENaC subunit alpha) and SCNN1B (ENaC subunit beta) C-terminal tails. Interacts with ENaC regulatory proteins NEDD4L, RAF1 and SGK1. Cytoplasm Apical cell membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BMA3-1; Sequence=Displayed; Name=2; IsoId=Q8BMA3-2; Sequence=VSP_029391, VSP_029615; Expressed in kidney. The PDZ domain is required for interaction with ENaC and SGK1, but not for interaction with NEDDL4 and RAF1. Belongs to the CNKSR family. molecular_function cellular_component cytoplasm plasma membrane regulation of signal transduction positive regulation of sodium ion transport membrane apical plasma membrane negative regulation of peptidyl-serine phosphorylation negative regulation of ERK1 and ERK2 cascade positive regulation of sodium ion transmembrane transporter activity uc007efb.1 uc007efb.2 uc007efb.3 
ENSMUST00000015358.8 Mtmr1 ENSMUST00000015358.8 myotubularin related protein 1, transcript variant 1 (from RefSeq NM_016985.3) ENSMUST00000015358.1 ENSMUST00000015358.2 ENSMUST00000015358.3 ENSMUST00000015358.4 ENSMUST00000015358.5 ENSMUST00000015358.6 ENSMUST00000015358.7 MTMR1_MOUSE NM_016985 Q9Z2C4 uc009tjt.1 uc009tjt.2 Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:12217958). Activity with phosphatidylinositol (3,5)- bisphosphate is controversial; it has been shown for the human ortholog (By similarity). In contrast, PubMed:12217958 find no activity with this substrate. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:39019, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57795, ChEBI:CHEBI:57923; EC=3.1.3.95; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3- phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3- phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:42328, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:65221, ChEBI:CHEBI:78934; Evidence=; Homodimer. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm Widely expressed. Detected in skeletal muscle, heart, lung, liver and brain. The C-terminal region is required for dimerization. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. phosphatidylinositol-3-phosphatase activity protein tyrosine phosphatase activity cytoplasm plasma membrane lipid metabolic process membrane dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation protein homodimerization activity phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity phosphatidylinositol phosphate phosphatase activity regulation of phosphatidylinositol dephosphorylation uc009tjt.1 uc009tjt.2 
ENSMUST00000015368.8 Cyp2j11 ENSMUST00000015368.8 cytochrome P450, family 2, subfamily j, polypeptide 11 (from RefSeq NM_001004141.2) Cyp2j11 Cyp2j11-ps ENSMUST00000015368.1 ENSMUST00000015368.2 ENSMUST00000015368.3 ENSMUST00000015368.4 ENSMUST00000015368.5 ENSMUST00000015368.6 ENSMUST00000015368.7 NM_001004141 Q3UNV2 Q3UNV2_MOUSE uc008tth.1 uc008tth.2 uc008tth.3 uc008tth.4 uc008tth.5 uc008tth.6 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc008tth.1 uc008tth.2 uc008tth.3 uc008tth.4 uc008tth.5 uc008tth.6 
ENSMUST00000015391.10 Nipsnap3b ENSMUST00000015391.10 nipsnap homolog 3B, transcript variant 1 (from RefSeq NM_025623.4) B1AWZ4 ENSMUST00000015391.1 ENSMUST00000015391.2 ENSMUST00000015391.3 ENSMUST00000015391.4 ENSMUST00000015391.5 ENSMUST00000015391.6 ENSMUST00000015391.7 ENSMUST00000015391.8 ENSMUST00000015391.9 NM_025623 NPS3B_MOUSE Nipsnap3a Q8VHX9 Q9CQE1 uc008swt.1 uc008swt.2 uc008swt.3 Cytoplasm, cytosol. Note=May be part of some vesicular structure distinct from lysosomal vesicles. Belongs to the NipSnap family. molecular_function cytoplasm mitochondrion cytosol biological_process uc008swt.1 uc008swt.2 uc008swt.3 
ENSMUST00000015394.10 Mmp13 ENSMUST00000015394.10 matrix metallopeptidase 13 (from RefSeq NM_008607.2) ENSMUST00000015394.1 ENSMUST00000015394.2 ENSMUST00000015394.3 ENSMUST00000015394.4 ENSMUST00000015394.5 ENSMUST00000015394.6 ENSMUST00000015394.7 ENSMUST00000015394.8 ENSMUST00000015394.9 Mmp13 NM_008607 Q3U9V5 Q3U9V5_MOUSE uc009ocg.1 uc009ocg.2 uc009ocg.3 uc009ocg.4 This gene encodes a member of the matrix metalloproteinase family that plays a role in wound healing, skeletal development and bone remodeling. The encoded protein is activated by the removal of an N-terminal activation peptide to generate a zinc-dependent endopeptidase enzyme that can cleave various native collagens, including types I - IV, X and XIV. Mice lacking the encoded protein display profound defects in growth plate cartilage as well as a delay in the endochondral bone development. Lack of the encoded protein also impairs the wound healing process due to reduced keratinocyte migration and vascular density at the wound site. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Jun 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC125320.1, AK150728.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Can bind about 5 Ca(2+) ions per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. Secreted Belongs to the peptidase M10A family. metalloendopeptidase activity calcium ion binding collagen binding extracellular region proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity extracellular matrix disassembly collagen catabolic process extracellular matrix metal ion binding bone morphogenesis uc009ocg.1 uc009ocg.2 uc009ocg.3 uc009ocg.4 
ENSMUST00000015433.4 Lage3 ENSMUST00000015433.4 L antigen family, member 3 (from RefSeq NM_025410.2) ENSMUST00000015433.1 ENSMUST00000015433.2 ENSMUST00000015433.3 Itba2 LAGE3_MOUSE Lage3 NM_025410 Q9CR70 uc009tor.1 uc009tor.2 uc009tor.3 Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex. Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes. Cytoplasm Nucleus Mouse embryos display primary microcephaly characterized by significantly shorter cortex lengths, cortex-midbrain midline lengths and cortex widths. Mice do not show a renal phenotype. Belongs to the CTAG/PCC1 family. EKC/KEOPS complex molecular_function nucleus cytoplasm tRNA processing positive regulation of transcription from RNA polymerase II promoter tRNA threonylcarbamoyladenosine metabolic process uc009tor.1 uc009tor.2 uc009tor.3 
ENSMUST00000015435.11 Gdi1 ENSMUST00000015435.11 GDP dissociation inhibitor 1 (from RefSeq NM_010273.4) A2AMA8 ENSMUST00000015435.1 ENSMUST00000015435.10 ENSMUST00000015435.2 ENSMUST00000015435.3 ENSMUST00000015435.4 ENSMUST00000015435.5 ENSMUST00000015435.6 ENSMUST00000015435.7 ENSMUST00000015435.8 ENSMUST00000015435.9 GDIA_MOUSE NM_010273 P50396 Q3TBI9 Q8VHM3 Q91Y71 Q91Z41 Q96CX5 Rabgdia uc009tom.1 uc009tom.2 uc009tom.3 uc009tom.4 Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. Interacts with RHOH (By similarity). Interacts with the non- phosphorylated forms of RAB1A, RAB3A, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB12, RAB35, and RAB43 (By similarity). Interacts with RAB10 (PubMed:19570034). Cytoplasm Golgi apparatus, trans- Golgi network High expression in brain, lower in other tissues. Belongs to the Rab GDI family. GDP-dissociation inhibitor activity Rab GDP-dissociation inhibitor activity GTPase activator activity cytoplasm Golgi apparatus small GTPase mediated signal transduction protein transport vesicle-mediated transport Rab GTPase binding axon midbody Rab protein signal transduction macromolecular complex neuron projection neuronal cell body myelin sheath positive regulation of GTPase activity positive regulation of axon extension negative regulation of axonogenesis regulation of catalytic activity response to calcium ion negative regulation of protein targeting to membrane uc009tom.1 uc009tom.2 uc009tom.3 uc009tom.4 
ENSMUST00000015449.6 Sash1 ENSMUST00000015449.6 SAM and SH3 domain containing 1 (from RefSeq NM_175155.4) ENSMUST00000015449.1 ENSMUST00000015449.2 ENSMUST00000015449.3 ENSMUST00000015449.4 ENSMUST00000015449.5 F8VQK5 F8VQK5_MOUSE NM_175155 Sash1 uc007eiu.1 uc007eiu.2 protein polyubiquitination G-protein alpha-subunit binding cytoplasm protein C-terminus binding positive regulation of endothelial cell migration regulation of epithelial cell migration protein kinase binding mitogen-activated protein kinase kinase kinase binding positive regulation of lipopolysaccharide-mediated signaling pathway macromolecular complex positive regulation of JUN kinase activity positive regulation of angiogenesis binding, bridging regulation of protein K63-linked ubiquitination positive regulation of p38MAPK cascade positive regulation of NIK/NF-kappaB signaling regulation of protein autoubiquitination uc007eiu.1 uc007eiu.2 
ENSMUST00000015456.10 Gadd45b ENSMUST00000015456.10 growth arrest and DNA-damage-inducible 45 beta (from RefSeq NM_008655.1) ENSMUST00000015456.1 ENSMUST00000015456.2 ENSMUST00000015456.3 ENSMUST00000015456.4 ENSMUST00000015456.5 ENSMUST00000015456.6 ENSMUST00000015456.7 ENSMUST00000015456.8 ENSMUST00000015456.9 GA45B_MOUSE Myd118 NM_008655 P22339 Q3U342 Q9R106 uc007gfl.1 uc007gfl.2 uc007gfl.3 Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity). Interacts with GADD45GIP1. P22339; Q8TAE8: GADD45GIP1; Xeno; NbExp=3; IntAct=EBI-2266938, EBI-372506; In myeloid precursor enriched BM cells. By cytokines. Belongs to the GADD45 family. activation of MAPKKK activity activation of MAPKK activity protein binding nucleus cytoplasm negative regulation of protein kinase activity apoptotic process multicellular organism development cell differentiation positive regulation of apoptotic process positive regulation of JNK cascade regulation of cell cycle positive regulation of p38MAPK cascade uc007gfl.1 uc007gfl.2 uc007gfl.3 
ENSMUST00000015460.5 Slamf1 ENSMUST00000015460.5 signaling lymphocytic activation molecule family member 1, transcript variant 1 (from RefSeq NM_013730.4) ENSMUST00000015460.1 ENSMUST00000015460.2 ENSMUST00000015460.3 ENSMUST00000015460.4 NM_013730 Q9QUM4 Q9QXZ3 SLAF1_MOUSE Slam uc007dpc.1 uc007dpc.2 uc007dpc.3 Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (By similarity). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (By similarity). Mediates IL-2-independent proliferation of activated T- cells during immune responses and induces IFN-gamma production (PubMed:9126961, PubMed:12351401). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T- cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (PubMed:11477403, PubMed:16847311, PubMed:15539155). Promotes T-cell receptor-induced IL- 4 secretion by CD4(+) cells (PubMed:15123745). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (PubMed:11477403). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (PubMed:20525889). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (By similarity). May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (PubMed:16528012). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (PubMed:18031695). Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (PubMed:18606638). In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (PubMed:15123745). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (PubMed:15315965). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (PubMed:25926831). (Microbial infection) Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulated of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396, PubMed:22493499). Interacts (via cytoplasmic domain) with SH2D1A and SH2D1B; SH2D1A mediates association with FYN; SH2D1A binds to phosphorylated and not phosphorylated ITSM 1 (PubMed:9774102, PubMed:16847311, PubMed:11477403). Interacts (via cytoplasmic domain phosphorylated on tyrosine residues) with INPP5D and PTPN11; presence of SH2D1A facilitates binding to INPP5D (By similarity). Interacts with MAP4K1 (By similarity). Interacts with PIK3C3, BECN1 and UVRAG; indicative for an association with PI3K complex II (PI3KC3-C2) (PubMed:22493499). Q9QUM4; P39688: Fyn; NbExp=4; IntAct=EBI-7910086, EBI-524514; Q9QUM4; O88890: Sh2d1a; NbExp=3; IntAct=EBI-7910086, EBI-7910438; Q9QUM4; Q14457: BECN1; Xeno; NbExp=8; IntAct=EBI-7910086, EBI-949378; Q9QUM4; Q9P2Y5: UVRAG; Xeno; NbExp=6; IntAct=EBI-7910086, EBI-2952704; Cell membrane ; Single-pass type I membrane protein. Note=Present on the surface of B- cells and T-cells. Located at the plasma membrane contacts between neighboring T cells. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q9QUM4-1; Sequence=Displayed; Name=Short; IsoId=Q9QUM4-2; Sequence=VSP_002570; The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain- containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. For SLAMF1 a 'two-out-of- three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3). Binding is mediated by either three 'prongs' (for high affinity binding involving ITSM 1) or a combination of any two also including non-phosphorylated Tyr-288 of ITSM 1 thus providing a positive feedback loop implicating SH2D1A-dependent recruitment of activating FYN. ITSM 2 needs to be phosphorylated on Tyr-335 for SH2D1A binding. Phosphorylated on tyrosine residues by FYN (By similarity). natural killer cell differentiation natural killer cell proliferation leukocyte chemotaxis involved in inflammatory response adaptive immune response myeloid dendritic cell activation involved in immune response immune system process negative regulation of T cell cytokine production protein binding plasma membrane phagocytosis cell adhesion external side of plasma membrane cell surface positive regulation of macrophage chemotaxis membrane integral component of membrane regulation of vesicle fusion negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production T-helper 1 cell cytokine production signaling receptor activity positive regulation of activated T cell proliferation identical protein binding innate immune response phagocytic vesicle positive regulation of JNK cascade lymphocyte activation regulation of catalytic activity positive regulation of ERK1 and ERK2 cascade negative regulation of interferon-gamma secretion positive regulation of interferon-gamma secretion negative regulation of CD40 signaling pathway positive regulation of dendritic cell chemotaxis uc007dpc.1 uc007dpc.2 uc007dpc.3 
ENSMUST00000015467.9 Slc39a1 ENSMUST00000015467.9 solute carrier family 39 (zinc transporter), member 1, transcript variant 1 (from RefSeq NM_013901.3) A2RTD4 ENSMUST00000015467.1 ENSMUST00000015467.2 ENSMUST00000015467.3 ENSMUST00000015467.4 ENSMUST00000015467.5 ENSMUST00000015467.6 ENSMUST00000015467.7 ENSMUST00000015467.8 NM_013901 Q99K44 Q9QZ03 S39A1_MOUSE Zip1 Zirtl uc012csu.1 uc012csu.2 uc012csu.3 Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29352; Evidence=; Kinetic parameters: KM=1.7 uM for Zn(2+) ; Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines. Ubiquitous, except in the pancreas (PubMed:10610721, PubMed:14525987). Highest levels seen in kidney, salivary gland and placenta. Found to be developmentally regulated in the skin where it is expressed in the epidermal layer, excluding the dermis, at embryonic day 17.5 dpc but not in 10.5 dpc and 15.5 dpc. In the small intestine found toward the base of the intestinal villi from 17.5 dpc. In the pancreas, expression was detected from 17.5 dpc and no expression was found in the liver. Also expressed in osteoblasts of developing bone from 15.5 dpc. Belongs to the ZIP transporter (TC 2.A.5) family. Sequence=CAB59982.1; Type=Frameshift; Evidence=; in utero embryonic development receptor binding zinc ion transmembrane transporter activity plasma membrane ion transport zinc II ion transport membrane integral component of membrane metal ion transport metal ion transmembrane transporter activity embryonic cranial skeleton morphogenesis transmembrane transport limb development zinc II ion transmembrane transport uc012csu.1 uc012csu.2 uc012csu.3 
ENSMUST00000015481.6 Endog ENSMUST00000015481.6 endonuclease G, transcript variant 4 (from RefSeq NR_184727.1) ENSMUST00000015481.1 ENSMUST00000015481.2 ENSMUST00000015481.3 ENSMUST00000015481.4 ENSMUST00000015481.5 Endog NR_184727 Q3UN47 Q3UN47_MOUSE uc008jbk.1 uc008jbk.2 uc008jbk.3 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Belongs to the DNA/RNA non-specific endonuclease family. nucleic acid binding endonuclease activity deoxyribonuclease activity nucleus mitochondrion cytosol DNA metabolic process aging response to mechanical stimulus hydrolase activity response to estradiol cellular response to oxidative stress neuron death in response to oxidative stress perikaryon metal ion binding cellular response to calcium ion cellular response to glucose stimulus cellular response to hypoxia nucleic acid phosphodiester bond hydrolysis positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of apoptotic DNA fragmentation uc008jbk.1 uc008jbk.2 uc008jbk.3 
ENSMUST00000015484.10 Cybb ENSMUST00000015484.10 cytochrome b-245, beta polypeptide (from RefSeq NM_007807.5) CY24B_MOUSE Cgd Cybb ENSMUST00000015484.1 ENSMUST00000015484.2 ENSMUST00000015484.3 ENSMUST00000015484.4 ENSMUST00000015484.5 ENSMUST00000015484.6 ENSMUST00000015484.7 ENSMUST00000015484.8 ENSMUST00000015484.9 NM_007807 Q61093 uc009spv.1 uc009spv.2 uc009spv.3 uc009spv.4 uc009spv.5 This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC042838.1, AK033570.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1. Interacts with calprotectin (S100A8/9) (By similarity). Interacts with NRROS; the interaction is direct and impairs formation of a stable NADPH oxidase complex (PubMed:24739962). Interacts with CYBC1; CYBC1 may act as a chaperone stabilizing Cytochrome b-245 heterodimer (By similarity). Interacts with NCF2; the interaction is enhanced in the presence of GBP7 (PubMed:21551061). The CYBA-CYBB complex interacts with GBP7 (PubMed:21551061). Q61093; Q61462: Cyba; NbExp=4; IntAct=EBI-6654585, EBI-15795776; Q61093; Q8BMT4: Nrros; NbExp=4; IntAct=EBI-6654585, EBI-16102695; Cell membrane; Multi-pass membrane protein. Note=As unassembled monomer may localize to the endoplasmic reticulum. Glycosylated. Phosphorylated on Ser and Thr residues. Undergoes 'Lys-48'-linked polyubiquitination, likely by RNF145, triggering endoplasmic reticulum-associated degradation. Mutants have a very sever defect in controlling bacterial replication. voltage-gated ion channel activity protein binding nuclear envelope cytoplasm mitochondrion endoplasmic reticulum rough endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane superoxide metabolic process ion transport defense response inflammatory response response to nutrient electron carrier activity membrane integral component of membrane superoxide-generating NADPH oxidase activity oxidoreductase activity heme binding electron transport chain dendrite ion transmembrane transport regulation of ion transmembrane transport response to drug positive regulation of tumor necrosis factor biosynthetic process superoxide anion generation NADPH oxidase complex neuronal cell body innate immune response phagocytic vesicle respiratory burst positive regulation of angiogenesis metal ion binding protein heterodimerization activity flavin adenine dinucleotide binding hydrogen peroxide biosynthetic process oxidation-reduction process cellular response to cadmium ion cellular response to ethanol cellular response to hypoxia perinuclear endoplasmic reticulum hypoxia-inducible factor-1alpha signaling pathway response to aldosterone cellular response to L-glutamine response to angiotensin uc009spv.1 uc009spv.2 uc009spv.3 uc009spv.4 uc009spv.5 
ENSMUST00000015486.7 Xk ENSMUST00000015486.7 X-linked Kx blood group (from RefSeq NM_023500.2) ENSMUST00000015486.1 ENSMUST00000015486.2 ENSMUST00000015486.3 ENSMUST00000015486.4 ENSMUST00000015486.5 ENSMUST00000015486.6 NM_023500 Q9QXY7 XK_MOUSE Xk Xkh Xkr1 Xrg1 uc009spq.1 uc009spq.2 uc009spq.3 Recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane. Heterodimer with Kell; disulfide-linked. Interacts with VPS13A. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the XK family. cell amino acid transport cellular calcium ion homeostasis regulation of cell size cellular magnesium ion homeostasis membrane integral component of membrane regulation of axon diameter myelination skeletal muscle fiber development uc009spq.1 uc009spq.2 uc009spq.3 
ENSMUST00000015498.9 Pcolce2 ENSMUST00000015498.9 procollagen C-endopeptidase enhancer 2 (from RefSeq NM_029620.2) ENSMUST00000015498.1 ENSMUST00000015498.2 ENSMUST00000015498.3 ENSMUST00000015498.4 ENSMUST00000015498.5 ENSMUST00000015498.6 ENSMUST00000015498.7 ENSMUST00000015498.8 NM_029620 PCOC2_MOUSE Pcpe2 Q3V1K6 Q8R4W6 Q9CX06 uc009rbg.1 uc009rbg.2 uc009rbg.3 Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1. Interacts with heparin with high affinity, and type I or II collagen. Secreted Expressed at all stages of development, with expression level decreasing from 7 to 11 dpc and more abundant levels of expression at 15 and 17 dpc. First detectable at relatively low level at 10.5 dpc in the area of the third and fourth branchial arches. At 13.5 dpc easily discernible expression seems primarily confined to the cartilage primordia of future bones. At 15.5 dpc expressed at the highest levels in skeletal elements in the interior non-ossified regions of cartilaginous structures and excluded from regions of ossification. O-glycosylated; contains sialic acid. extracellular matrix structural constituent collagen binding extracellular region heparin binding positive regulation of peptidase activity peptidase activator activity cellular response to leukemia inhibitory factor uc009rbg.1 uc009rbg.2 uc009rbg.3 
ENSMUST00000015511.15 Plxnd1 ENSMUST00000015511.15 plexin D1 (from RefSeq NM_026376.4) ENSMUST00000015511.1 ENSMUST00000015511.10 ENSMUST00000015511.11 ENSMUST00000015511.12 ENSMUST00000015511.13 ENSMUST00000015511.14 ENSMUST00000015511.2 ENSMUST00000015511.3 ENSMUST00000015511.4 ENSMUST00000015511.5 ENSMUST00000015511.6 ENSMUST00000015511.7 ENSMUST00000015511.8 ENSMUST00000015511.9 NM_026376 PLXD1_MOUSE Q3UH93 Q68HV1 uc009djn.1 uc009djn.2 Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Mediates anti-angiogenic signaling in response to SEMA3E. Required for normal development of the heart and vasculature. Interacts with NRP1 and SEMA4A (PubMed:15239958, PubMed:17318185). Interacts with SH3BP1; they dissociate upon SEMA3E binding to PLXND1 allowing SH3BP1 to transduce downstream signal through RAC1 inactivation (By similarity). Cell membrane ingle-pass membrane protein Cell projection, lamellipodium membrane Detected in embryonic heart and vascular endothelium, brain, dorsal root ganglia, adrenal gland, lung mesenchyme, small intestine and in the ossification centers of vertebral bodies. Neonate lethality, due to defects in the development of the heart outflow tract and in aortic arch patterning, plus defects in peripheral vasculature. Mice also display skeletal defects, but these may be caused by defects in the embryonic vasculature. Belongs to the plexin family. angiogenesis branching involved in blood vessel morphogenesis semaphorin receptor complex outflow tract morphogenesis cardiac septum development protein binding plasma membrane integral component of plasma membrane negative regulation of cell adhesion signal transduction multicellular organism development synapse assembly regulation of cell shape membrane integral component of membrane semaphorin receptor activity protein domain specific binding lamellipodium regulation of cell migration lamellipodium membrane positive regulation of protein binding aorta development cell projection regulation of GTPase activity endothelial cell migration regulation of angiogenesis positive regulation of axonogenesis dichotomous subdivision of terminal units involved in salivary gland branching coronary vasculature development semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway involved in axon guidance uc009djn.1 uc009djn.2 
ENSMUST00000015540.4 Cd83 ENSMUST00000015540.4 CD83 antigen, transcript variant 1 (from RefSeq NM_009856.4) CD83_MOUSE ENSMUST00000015540.1 ENSMUST00000015540.2 ENSMUST00000015540.3 NM_009856 O88324 uc007qgk.1 uc007qgk.2 uc007qgk.3 uc007qgk.4 uc007qgk.5 May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. Monomer. Membrane ; Single-pass type I membrane protein Abundantly expressed in spleen and brain, but is also detected in most tissues analyzed. external side of plasma membrane response to organic cyclic compound membrane integral component of membrane negative regulation of interleukin-4 production positive regulation of interleukin-10 production positive regulation of interleukin-2 production positive regulation of CD4-positive, alpha-beta T cell differentiation uc007qgk.1 uc007qgk.2 uc007qgk.3 uc007qgk.4 uc007qgk.5 
ENSMUST00000015576.6 Mcpt2 ENSMUST00000015576.6 mast cell protease 2 (from RefSeq NM_008571.2) ENSMUST00000015576.1 ENSMUST00000015576.2 ENSMUST00000015576.3 ENSMUST00000015576.4 ENSMUST00000015576.5 Mcpt2 NM_008571 Q541U2 Q541U2_MOUSE uc007ubk.1 uc007ubk.2 uc007ubk.3 serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc007ubk.1 uc007ubk.2 uc007ubk.3 
ENSMUST00000015578.5 Gzmg ENSMUST00000015578.5 granzyme G (from RefSeq NM_010375.2) ENSMUST00000015578.1 ENSMUST00000015578.2 ENSMUST00000015578.3 ENSMUST00000015578.4 Gzmg NM_010375 Q4KL28 Q4KL28_MOUSE uc007ubq.1 uc007ubq.2 uc007ubq.3 Cytolytic granule serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc007ubq.1 uc007ubq.2 uc007ubq.3 
ENSMUST00000015581.6 Gzmb ENSMUST00000015581.6 granzyme B (from RefSeq NM_013542.3) ENSMUST00000015581.1 ENSMUST00000015581.2 ENSMUST00000015581.3 ENSMUST00000015581.4 ENSMUST00000015581.5 Gzmb NM_013542 Q3TZH4 Q3TZH4_MOUSE uc007ubv.1 uc007ubv.2 uc007ubv.3 uc007ubv.4 This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Mice lacking a functional copy of this gene exhibit impaired immune cell-mediated cytolysis. [provided by RefSeq, Sep 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002085.1, X04072.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc007ubv.1 uc007ubv.2 uc007ubv.3 uc007ubv.4 
ENSMUST00000015583.2 Ctsg ENSMUST00000015583.2 cathepsin G (from RefSeq NM_007800.2) Ctsg ENSMUST00000015583.1 NM_007800 Q059V7 Q059V7_MOUSE uc007ubn.1 uc007ubn.2 uc007ubn.3 uc007ubn.4 This gene encodes a member of the peptidase S1 (chymotrypsin) family of serine endopeptidases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product appears to play a role in host defense, including inflammation and antigen processing. Homozygous knockout mice for this gene exhibit enhanced susceptibility to bacterial and fungal infection. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X78544.1, BC125511.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## serine-type endopeptidase activity plasma membrane protein phosphorylation proteolysis heparin binding peptidase activity serine-type peptidase activity cytoplasmic stress granule hydrolase activity antibacterial humoral response secretory granule defense response to Gram-negative bacterium cellular response to lipopolysaccharide uc007ubn.1 uc007ubn.2 uc007ubn.3 uc007ubn.4 
ENSMUST00000015585.4 Gzmc ENSMUST00000015585.4 granzyme C, transcript variant 1 (from RefSeq NM_010371.4) ENSMUST00000015585.1 ENSMUST00000015585.2 ENSMUST00000015585.3 Gzmc NM_010371 Q0VB76 Q0VB76_MOUSE uc007ubu.1 uc007ubu.2 uc007ubu.3 uc007ubu.4 uc007ubu.5 uc007ubu.6 This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product, expressed by activated T cells, may induce apoptosis of target cells. This gene is present in a gene cluster with other members of the granzyme subfamily on chromosome 14. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M18459.1, X12822.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## serine-type endopeptidase activity proteolysis uc007ubu.1 uc007ubu.2 uc007ubu.3 uc007ubu.4 uc007ubu.5 uc007ubu.6 
ENSMUST00000015587.9 Gzmn ENSMUST00000015587.9 granzyme N, transcript variant 2 (from RefSeq NM_153052.3) ENSMUST00000015587.1 ENSMUST00000015587.2 ENSMUST00000015587.3 ENSMUST00000015587.4 ENSMUST00000015587.5 ENSMUST00000015587.6 ENSMUST00000015587.7 ENSMUST00000015587.8 GrN Gzmn NM_153052 Q920S1 Q920S1_MOUSE uc007ubr.1 uc007ubr.2 uc007ubr.3 uc007ubr.4 Cytolytic granule serine-type endopeptidase activity cytoplasm proteolysis peptidase activity serine-type peptidase activity granzyme-mediated apoptotic signaling pathway hydrolase activity uc007ubr.1 uc007ubr.2 uc007ubr.3 uc007ubr.4 
ENSMUST00000015594.9 Mcpt8 ENSMUST00000015594.9 mast cell protease 8 (from RefSeq NM_008572.1) ENSMUST00000015594.1 ENSMUST00000015594.2 ENSMUST00000015594.3 ENSMUST00000015594.4 ENSMUST00000015594.5 ENSMUST00000015594.6 ENSMUST00000015594.7 ENSMUST00000015594.8 Mcpt8 NM_008572 Q3UWB6 Q3UWB6_MOUSE uc007ubm.1 uc007ubm.2 uc007ubm.3 uc007ubm.4 uc007ubm.5 serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc007ubm.1 uc007ubm.2 uc007ubm.3 uc007ubm.4 uc007ubm.5 
ENSMUST00000015596.10 Ager ENSMUST00000015596.10 advanced glycosylation end product-specific receptor, transcript variant 1 (from RefSeq NM_007425.3) C5H3H4 C5H3H5 C5H3H7 C5H3I0 C5H7W3 C5H7W4 C5H7W5 C5H7W6 C5H7W7 C5H7W8 C5H7W9 ENSMUST00000015596.1 ENSMUST00000015596.2 ENSMUST00000015596.3 ENSMUST00000015596.4 ENSMUST00000015596.5 ENSMUST00000015596.6 ENSMUST00000015596.7 ENSMUST00000015596.8 ENSMUST00000015596.9 NM_007425 O35444 Q2PGG1 Q62151 RAGE_MOUSE Rage V5R4Y0 uc008ccx.1 uc008ccx.2 uc008ccx.3 uc008ccx.4 Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans (PubMed:21270403, PubMed:32670276). Advanced glycosylation end products are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. These ligands accumulate at inflammatory sites during the pathogenesis of various diseases, including diabetes, vascular complications, neurodegenerative disorders, and cancers and RAGE transduces their binding into pro- inflammatory responses. Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction or inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF- kappa-B. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (By similarity). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons (PubMed:19901339). ABPP- initiated RAGE signaling, especially stimulation of p38 mitogen- activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability (By similarity). Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome (By similarity). Promotes also extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (By similarity). [Isoform 2]: Is able to advanced glycosylation end product (AGE)-induce nuclear factor NF-kappa-B activation. [Isoform 10]: Down-regulates receptor for advanced glycosylation end products (RAGE)-ligand induced signaling through various MAPK pathways including ERK1/2, p38 and SAPK/JNK. Significantly affects tumor cell properties through decreasing cell migration, invasion, adhesion and proliferation, and increasing cellular apoptosis. Exhibits drastic inhibition on tumorigenesis in vitro. Constitutive homodimer; disulfide-linked. Forms homooligomers (By similarity). Interacts with S100A1 and APP (PubMed:19901339). Interacts with S100B, S100A12 and S100A14 (PubMed:10399917). Interacts with TIRAP (By similarity). Interacts with HMGB1 (By similarity). Q62151; Q02956: Prkcz; NbExp=7; IntAct=EBI-6665091, EBI-642057; [Isoform 1]: Membrane; Single-pass type I membrane protein. [Isoform 2]: Secreted [Isoform 10]: Cell membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=13; Name=1; Synonyms=mRAGE ; IsoId=Q62151-1; Sequence=Displayed; Name=2; Synonyms=mRAGE_v1 , mRAGE_v3 , endogenous secretory receptor for AGE (esRAGE) ; IsoId=Q62151-2; Sequence=VSP_058091, VSP_058092; Name=3; Synonyms=mRAGE_v4 ; IsoId=Q62151-3; Sequence=VSP_058090; Name=4; Synonyms=mRAGE_v15 ; IsoId=Q62151-4; Sequence=VSP_058080, VSP_058090; Name=5; Synonyms=mRAGE_v14 ; IsoId=Q62151-5; Sequence=VSP_058089; Name=6; Synonyms=mRAGE_v10 ; IsoId=Q62151-6; Sequence=VSP_058087, VSP_058088; Name=7; Synonyms=mRAGE_v7 ; IsoId=Q62151-7; Sequence=VSP_058083, VSP_058086; Name=8; Synonyms=mRAGE_v11 ; IsoId=Q62151-8; Sequence=VSP_058084, VSP_058085; Name=9; Synonyms=mRAGE_v9 ; IsoId=Q62151-9; Sequence=VSP_058076, VSP_058082; Name=10; Synonyms=RAGE deletion of intracellular domain , RAGEdeltaICD , mRAGE_v20 ; IsoId=Q62151-10; Sequence=VSP_058093, VSP_058094; Name=11; Synonyms=mRAGE_v2 , mRAGE_v5 , mRAGE_v6 , mRAGE_v8 , mRAGE_v16 , mRAGE_v17 ; IsoId=Q62151-11; Sequence=VSP_058075, VSP_058081; Name=12; Synonyms=mRAGE_v13 ; IsoId=Q62151-12; Sequence=VSP_058077, VSP_058079; Name=13; Synonyms=mRAGE_v12 ; IsoId=Q62151-13; Sequence=VSP_058078; Isoform 1: Expressed at higher levels in the coronary arterioles in type 2 diabetic mice (at protein level). Endothelial cells (PubMed:18539754). Expressed in lung, kidney, brain and heart. Most prevalent isoform with the highest level in heart (PubMed:19164451). Isoform 2: Expressed in brain, lung, kidney and small intestine with the highest level in lung. Expressed in brain, lung, kidney and small intestine with the highest level in small intestine (at protein level). Detected in neurons of the cerebrum, bronchial epithelium, endothelial cells, tubular cells of kidney and epithelial cells of small intestine (at protein level). Expression is increased in the kidney of diabetic wild-type mice (at protein level), but not in the other tissues (PubMed:16503878). Expressed only in kidney. Expression is increased in the kidney of diabetic mice (PubMed:19164451). Isoform 3: Expressed in lung, kidney and heart. The second most prevalent isoform with the highest level in lung. Not expressed in brain (PubMed:19164451). Isoform 4: Expressed at very low level in lung only (PubMed:19164451). Isoform 5: Expressed at very low level in lung only (PubMed:19164451). Isoform 6: Expressed at very low level in lung only (PubMed:19164451). Isoform 7: Expressed at very low level in heart only (PubMed:19164451). Isoform 8: Expressed at very low level in lung only (PubMed:19164451). Isoform 9: Expressed at very low level in heart only (PubMed:19164451). Isoform 10: Expressed in lung, brain, heart and kidney with a very high level in kidney (PubMed:24260107). Isoform 11: Expressed in brain, kidney and heart. Not expressed in lung (PubMed:19164451). Isoform 12: Expressed at very low level in lung and kidney (PubMed:19164451). Isoform 13: Expressed at very low level in lung only (PubMed:19164451). Phosphorylated on its cytoplasmic domain by PKCzeta/PRKCZ upon ligand binding. Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation. In deletion mutant mice, the elevation of serum TNF-alpha, IL6 and EDN1 and the tissue damage induced by LPS is significantly attenuated when compared with WT mice (PubMed:21270403). The lower hepatic expression of pro-inflammatory cytokines, while the activation of immune cells remains unaffected, results in improved survival after challenge with D-galactosamine (PubMed:32670276). [Isoform 7]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. [Isoform 8]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. [Isoform 9]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. [Isoform 11]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. beta-amyloid binding fibrillar center response to hypoxia microglial cell activation regulation of T cell mediated cytotoxicity negative regulation of protein phosphorylation positive regulation of protein phosphorylation negative regulation of endothelial cell proliferation protein binding extracellular region extracellular space cytoplasm cytosol plasma membrane inflammatory response negative regulation of cell adhesion JAK-STAT cascade learning or memory external side of plasma membrane basal plasma membrane cell surface glucose mediated signaling pathway positive regulation of autophagy negative regulation of endothelial cell migration positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of fibroblast migration astrocyte development positive regulation of smooth muscle cell migration membrane integral component of membrane apical plasma membrane positive regulation of signaling negative regulation of signaling cell junction positive regulation of cell migration negative regulation of cell migration axon neuron projection development negative regulation of interleukin-10 production positive regulation of interleukin-12 production negative regulation of collagen biosynthetic process positive regulation of heterotypic cell-cell adhesion signaling receptor activity positive regulation of activated T cell proliferation positive regulation of tumor necrosis factor biosynthetic process identical protein binding neuronal cell body positive regulation of apoptotic process positive regulation of JUN kinase activity positive regulation of neuron apoptotic process S100 protein binding macromolecular complex binding transcytosis positive regulation of chemokine biosynthetic process positive regulation of interleukin-6 biosynthetic process positive regulation of JNK cascade astrocyte activation positive regulation of fibroblast proliferation positive regulation of smooth muscle cell proliferation positive regulation of interleukin-1 beta biosynthetic process regulation of inflammatory response positive regulation of inflammatory response induction of positive chemotaxis positive regulation of NF-kappaB transcription factor activity regulation of DNA binding calcium ion homeostasis positive regulation of phagocytosis, engulfment positive regulation of ERK1 and ERK2 cascade high mobility group box 1 binding positive regulation of monocyte chemotactic protein-1 production protein localization to membrane modulation of age-related behavioral decline regulation of long-term synaptic potentiation negative regulation of long-term synaptic potentiation negative regulation of long term synaptic depression regulation of p38MAPK cascade positive regulation of p38MAPK cascade positive regulation of potassium ion transmembrane transporter activity positive regulation of neuron death positive regulation of NIK/NF-kappaB signaling positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of blood circulation positive regulation of endothelin secretion negative regulation of connective tissue replacement involved in inflammatory response wound healing advanced glycation end-product binding negative regulation of advanced glycation end-product receptor activity positive regulation of advanced glycation end-product receptor activity response to beta-amyloid cellular response to beta-amyloid positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process positive regulation of monocyte extravasation regulation of CD4-positive, alpha-beta T cell activation positive regulation of type B pancreatic cell apoptotic process positive regulation of dendritic cell differentiation uc008ccx.1 uc008ccx.2 uc008ccx.3 uc008ccx.4 
ENSMUST00000015605.15 Atf6b ENSMUST00000015605.15 activating transcription factor 6 beta (from RefSeq NM_017406.4) A0A0A0MQ69 A0A0A0MQ69_MOUSE Atf6b ENSMUST00000015605.1 ENSMUST00000015605.10 ENSMUST00000015605.11 ENSMUST00000015605.12 ENSMUST00000015605.13 ENSMUST00000015605.14 ENSMUST00000015605.2 ENSMUST00000015605.3 ENSMUST00000015605.4 ENSMUST00000015605.5 ENSMUST00000015605.6 ENSMUST00000015605.7 ENSMUST00000015605.8 ENSMUST00000015605.9 NM_017406 uc008cdh.1 uc008cdh.2 uc008cdh.3 uc008cdh.4 uc008cdh.5 Belongs to the bZIP family. ATF subfamily. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleolus endoplasmic reticulum membrane regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter endomembrane system endoplasmic reticulum unfolded protein response protein-DNA complex cAMP response element binding transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor complex negative regulation of ATF6-mediated unfolded protein response positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress uc008cdh.1 uc008cdh.2 uc008cdh.3 uc008cdh.4 uc008cdh.5 
ENSMUST00000015611.14 Egfl8 ENSMUST00000015611.14 EGF-like domain 8, transcript variant 2 (from RefSeq NM_152922.4) EGFL8_MOUSE ENSMUST00000015611.1 ENSMUST00000015611.10 ENSMUST00000015611.11 ENSMUST00000015611.12 ENSMUST00000015611.13 ENSMUST00000015611.2 ENSMUST00000015611.3 ENSMUST00000015611.4 ENSMUST00000015611.5 ENSMUST00000015611.6 ENSMUST00000015611.7 ENSMUST00000015611.8 ENSMUST00000015611.9 NM_152922 Ng3 O35447 Q3UFB4 Q6GUQ1 uc008cdb.1 uc008cdb.2 uc008cdb.3 uc008cdb.4 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6GUQ1-1; Sequence=Displayed; Name=2; IsoId=Q6GUQ1-2; Sequence=VSP_026672; Ubiquitously expressed in brain, kidney, thymus and lung. Not detected before 11.5 dpc and expression levels vary between 11.5 dpc and 15.5 dpc. receptor binding calcium ion binding extracellular region cell surface anatomical structure development in utero embryonic development uc008cdb.1 uc008cdb.2 uc008cdb.3 uc008cdb.4 
ENSMUST00000015612.14 Notch4 ENSMUST00000015612.14 notch 4 (from RefSeq NM_010929.2) A2CG28 ENSMUST00000015612.1 ENSMUST00000015612.10 ENSMUST00000015612.11 ENSMUST00000015612.12 ENSMUST00000015612.13 ENSMUST00000015612.2 ENSMUST00000015612.3 ENSMUST00000015612.4 ENSMUST00000015612.5 ENSMUST00000015612.6 ENSMUST00000015612.7 ENSMUST00000015612.8 ENSMUST00000015612.9 Int-3 Int3 NM_010929 NOTC4_MOUSE Notch4 O35442 O88314 O88316 P31695 Q62389 Q62390 Q9R1W9 Q9R1X0 uc008ccs.1 uc008ccs.2 uc008ccs.3 Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May regulate branching morphogenesis in the developing vascular system. Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4. P31695; Q93794: sel-10; Xeno; NbExp=2; IntAct=EBI-643670, EBI-323098; Cell membrane; Single-pass type I membrane protein. [Notch 4 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus. Highly expressed in lung, moderately in heart kidney, and at lower levels in the ovary and skeletal muscle. A very low expression is seen in the brain, intestine, liver and testis. Highly expressed in endothelial cells during embryonic development from 9.0 dpc. Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans- Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane- associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma- secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane. Phosphorylated. Note=Loss of the extracellular domain causes constitutive activation of the Notch protein, which leads to hyperproliferation of glandular epithelial tissues and development of mammary carcinomas. Belongs to the NOTCH family. Sequence=BAA32281.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin.; Evidence=; Sequence=BAA32283.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAA32284.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAA32285.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; branching involved in blood vessel morphogenesis morphogenesis of a branching structure endothelial cell morphogenesis vasculature development Notch binding calcium ion binding protein binding nucleus nucleoplasm endoplasmic reticulum cytosol plasma membrane regulation of transcription, DNA-templated Notch signaling pathway multicellular organism development regulation of Notch signaling pathway cell surface membrane integral component of membrane cell differentiation mammary gland development cytoplasmic vesicle regulation of protein localization signaling receptor activity endothelial cell differentiation negative regulation of endothelial cell differentiation negative regulation of Notch signaling pathway positive regulation of angiogenesis venous blood vessel morphogenesis regulation of developmental process regulation of protein processing positive regulation of aorta morphogenesis uc008ccs.1 uc008ccs.2 uc008ccs.3 
ENSMUST00000015620.7 Prrt1 ENSMUST00000015620.7 proline-rich transmembrane protein 1, transcript variant 1 (from RefSeq NM_030890.2) ENSMUST00000015620.1 ENSMUST00000015620.2 ENSMUST00000015620.3 ENSMUST00000015620.4 ENSMUST00000015620.5 ENSMUST00000015620.6 NM_030890 Ng5 O35449 PRRT1_MOUSE Prrt1 uc008cdf.1 uc008cdf.2 uc008cdf.3 Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function (PubMed:29490264). Regulates AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses (PubMed:29490264, PubMed:31216424). Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression (PubMed:31216424). Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Cell membrane ; Single-pass type II membrane protein Synapse Expressed in the brain (at protein level) (PubMed:22632720). In brain, expressed throughout the hippocampus with weak expression in the olfactory bulb and neocortex (at protein level) (PubMed:29490264). Decreased Gria1/GluA1 and Gria2/GluA2 density at extrasynaptic sites and increased density of Gria1 at synapses (PubMed:29490264). Reduced cell surface expression of Gria1 and Gria2 (PubMed:31216424). Reduced phosphorylation of Gria1 'Ser-863' and increased phosphorylation of Gria1 'Ser-849' (PubMed:31216424). Reduced synaptic transmission in immature hippocampal neurons (PubMed:29490264). No change in basal synaptic transmission in mature hippocampal neurons (PubMed:31216424). Shown to impair tetanus-induced long-term potentiation (LTP) in 8-12 week old mice in one study (PubMed:29490264). Another study shows no effect on LTP in young mature mice at postnatal days 24-36 (PubMed:31216424). Severely impaired long- term depression (PubMed:31216424). Deficiency in cognitive learning and memory tasks (PubMed:29490264). Belongs to the CD225/Dispanin family. molecular_function plasma membrane biological_process membrane integral component of membrane cell junction synapse glutamatergic synapse integral component of postsynaptic membrane uc008cdf.1 uc008cdf.2 uc008cdf.3 
ENSMUST00000015622.8 Rnf5 ENSMUST00000015622.8 ring finger protein 5 (from RefSeq NM_019403.3) ENSMUST00000015622.1 ENSMUST00000015622.2 ENSMUST00000015622.3 ENSMUST00000015622.4 ENSMUST00000015622.5 ENSMUST00000015622.6 ENSMUST00000015622.7 NM_019403 Ng2 O35445 RNF5_MOUSE Rnf5 uc008ccy.1 uc008ccy.2 uc008ccy.3 Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:23093945). May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (By similarity). Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (By similarity). Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (By similarity). Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (By similarity). Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with PXN (By similarity). Interacts with JKAMP (PubMed:16166642). Interacts with STING1; the interaction of endogenous proteins is dependent on viral infection (By similarity). Cell membrane ; Multi-pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles. Mice are more resistant to lethal infections by group A Streptococcus due to increased autophagy (PubMed:23093945). Macrophages show increased autophagosomes and more efficient bacterial clearance (PubMed:23093945). Belongs to the RNF5 family. ubiquitin-protein transferase activity protein binding mitochondrion endoplasmic reticulum endoplasmic reticulum membrane ubiquitin-dependent protein catabolic process response to bacterium negative regulation of autophagy membrane integral component of membrane protein ubiquitination transferase activity ER-associated ubiquitin-dependent protein catabolic process protein destabilization mitochondrial membrane ERAD pathway identical protein binding cellular protein catabolic process ubiquitin-like protein conjugating enzyme binding macromolecular complex binding metal ion binding ubiquitin protein ligase activity protein K63-linked ubiquitination protein K48-linked ubiquitination ER-associated misfolded protein catabolic process regulation of autophagosome assembly uc008ccy.1 uc008ccy.2 uc008ccy.3 
ENSMUST00000015628.4 Fam163a ENSMUST00000015628.4 family with sequence similarity 163, member A (from RefSeq NM_177838.3) ENSMUST00000015628.1 ENSMUST00000015628.2 ENSMUST00000015628.3 F163A_MOUSE NM_177838 Q8CAA5 uc033fmn.1 uc033fmn.2 uc033fmn.3 Membrane ; Single-pass membrane protein Belongs to the FAM163 family. molecular_function cellular_component biological_process membrane integral component of membrane uc033fmn.1 uc033fmn.2 uc033fmn.3 
ENSMUST00000015663.7 2310057J18Rik ENSMUST00000015663.7 RIKEN cDNA 2310057J18 gene (from RefSeq NM_026336.3) ENSMUST00000015663.1 ENSMUST00000015663.2 ENSMUST00000015663.3 ENSMUST00000015663.4 ENSMUST00000015663.5 ENSMUST00000015663.6 LEG1H_MOUSE Leg1 NM_026336 Q8C6C9 Q8C6D2 Q8C6D6 Q8VDJ0 Q9CPV8 Q9CQ55 Q9D6S4 Q9D745 Q9D775 Q9D7F4 Q9D865 uc007esr.1 uc007esr.2 uc007esr.3 uc007esr.4 May be involved in early liver development. Secreted Belongs to the LEG1 family. Sequence=AAH21783.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB26311.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB26664.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function extracellular region extracellular space multicellular organism development biological_process uc007esr.1 uc007esr.2 uc007esr.3 uc007esr.4 
ENSMUST00000015664.5 Ctsk ENSMUST00000015664.5 cathepsin K (from RefSeq NM_007802.4) Ctsk ENSMUST00000015664.1 ENSMUST00000015664.2 ENSMUST00000015664.3 ENSMUST00000015664.4 NM_007802 Q545T0 Q545T0_MOUSE uc008qjy.1 uc008qjy.2 uc008qjy.3 uc008qjy.4 This gene encodes a member of the cathepsin family of cysteine proteases that is highly expressed in osteoclasts and is involved in the degradation of collagen and other matrix proteins in bone. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme. Mice lacking the encoded protein exhibit phenotypic features of pycnodysostosis such as increased bone density and bone deformity, which become progressively more pronounced with age. [provided by RefSeq, Jan 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC046320.1, AK132648.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Reaction=Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.; EC=3.4.22.38; Evidence=; Apical cell membrane ; Peripheral membrane protein ; Extracellular side Cell membrane ; Peripheral membrane protein ; Extracellular side Lysosome Secreted Belongs to the peptidase C1 family. intramembranous ossification fibronectin binding cysteine-type endopeptidase activity collagen binding extracellular space nucleoplasm cytoplasm lysosome proteolysis cysteine-type peptidase activity collagen catabolic process intracellular membrane-bounded organelle proteoglycan binding bone resorption proteolysis involved in cellular protein catabolic process uc008qjy.1 uc008qjy.2 uc008qjy.3 uc008qjy.4 
ENSMUST00000015667.9 Ctss ENSMUST00000015667.9 cathepsin S, transcript variant 1 (from RefSeq NM_001267695.2) Ctss ENSMUST00000015667.1 ENSMUST00000015667.2 ENSMUST00000015667.3 ENSMUST00000015667.4 ENSMUST00000015667.5 ENSMUST00000015667.6 ENSMUST00000015667.7 ENSMUST00000015667.8 F6WR04 F6WR04_MOUSE NM_001267695 uc008qka.1 uc008qka.2 uc008qka.3 uc008qka.4 uc008qka.5 This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, which encode preproproteins that are proteolytically processed to generate mature protein products. This enzyme is secreted by antigen-presenting cells during inflammation and may induce pain and itch via activation of G-protein coupled receptors. Homozygous knockout mice for this gene exhibit impaired wound healing, reduced tumorigenesis in a pancreatic cancer model, and reduced pathogenesis in a myasthenia gravis model. [provided by RefSeq, Aug 2015]. Reaction=Similar to cathepsin L, but with much less activity on Z-Phe- Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.; EC=3.4.22.27; Evidence=; Cytoplasmic vesicle, phagosome Lysosome Belongs to the peptidase C1 family. fibronectin binding adaptive immune response cysteine-type endopeptidase activity collagen binding extracellular space lysosome late endosome proteolysis peptidase activity cysteine-type peptidase activity response to acidic pH protein processing hydrolase activity collagen catabolic process basement membrane disassembly intracellular membrane-bounded organelle laminin binding proteoglycan binding antigen processing and presentation of peptide antigen proteolysis involved in cellular protein catabolic process cellular response to thyroid hormone stimulus positive regulation of cation channel activity uc008qka.1 uc008qka.2 uc008qka.3 uc008qka.4 uc008qka.5 
ENSMUST00000015712.15 Lpl ENSMUST00000015712.15 lipoprotein lipase (from RefSeq NM_008509.2) ENSMUST00000015712.1 ENSMUST00000015712.10 ENSMUST00000015712.11 ENSMUST00000015712.12 ENSMUST00000015712.13 ENSMUST00000015712.14 ENSMUST00000015712.2 ENSMUST00000015712.3 ENSMUST00000015712.4 ENSMUST00000015712.5 ENSMUST00000015712.6 ENSMUST00000015712.7 ENSMUST00000015712.8 ENSMUST00000015712.9 LIPL_MOUSE NM_008509 P11152 Q05956 Q542L4 Q9D3M9 Q9DCM8 uc009lwq.1 uc009lwq.2 uc009lwq.3 Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:8675619). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (PubMed:24726386). Recruited to its site of action on vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (PubMed:20620994, PubMed:24726386, PubMed:27811232). Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.34; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + di-(9Z)-octadecenoylglycerol + H(+); Xref=Rhea:RHEA:38575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38576; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38699, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669, ChEBI:CHEBI:76083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38700; Evidence=; Reaction=1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+); Xref=Rhea:RHEA:40475, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:35020, ChEBI:CHEBI:76478; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40476; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:41384, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41385; Evidence=; The apolipoprotein APOC2 acts as a coactivator of LPL activity (By similarity). Ca(2+) binding promotes protein stability and formation of the active homodimer. Interaction with GPIHBP1 protects LPL against inactivation by ANGPTL4 (By similarity). Homodimer (PubMed:25066055). Interacts with GPIHBP1 with 1:1 stoichiometry (PubMed:17403372, PubMed:20620994, PubMed:24726386). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids (By similarity). Interaction with heparan sulfate proteoglycans is required to protect LPL against loss of activity. Associates with lipoprotein particles in blood plasma (By similarity). Interacts with LMF1 and SEL1L; interaction with SEL1L is required to prevent aggregation of newly synthesized LPL in the endoplasmic reticulum (ER), and for normal export of LPL from the ER to the extracellular space (PubMed:25066055). Interacts with SORL1; SORL1 acts as a sorting receptor, promoting LPL localization to endosomes and later to lysosomes, leading to degradation of newly synthesized LPL (By similarity). Cell membrane eripheral membrane protein Extracellular side creted Secreted, extracellular space, extracellular matrix Note=Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently, it becomes attached to heparan proteoglycan on endothelial cells (PubMed:27811232). Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non- coated endocytic vesicles (By similarity). Detected in white and brown adipose tissue and heart muscle, especially at the lumenal surface of capillaries (PubMed:25066055, PubMed:27811232, PubMed:20620994). Detected on capillary endothelium in the lactating mammary gland (PubMed:27811232). Detected in blood plasma (at protein level) (PubMed:17403372, PubMed:25066055). Expressed in liver, epididymal fat, heart, psoas muscle, lactating mammary gland, adrenal, lung, and ovary. Highest levels in heart and adrenal gland. Maximum expression in adipose tissue during early development. In heart, low levels 6 days before birth increasing 278- fold as animals reach adulthood. Tyrosine nitration after lipopolysaccharide (LPS) challenge down- regulates the lipase activity. N-glycosylated. Mice are born at the expected Mendelian rate. At birth, mutant pups have threefold higher plasma triglyceride levels and sevenfold higher VLDL cholesterol levels relative to wild-type. After suckling they become progressively pale, then cyanotic, and die at about 18 hours after birth. At 18 hours after birth, their plasma triglyceride levels reach 15'090 mg/dl, compared to 188 mg/dl for wild- type. At the same time point, VLDL cholesterol levels reach 280 mg/dl in mutant pups, compared to 6 mg/dl in wild-type. Mutant pups show severly reduced adipose tissue, and their livers are deficient in intracellular lipid droplets. Likewise, the numbers of intracellular lipid droplets in skeletal muscle are severely reduced. Lungs display lipid-filled alveoli and dilated capillaries that are engorged with lipoprotein particles. These particles are marginated and seem to block the access of red blood cells to the vascular endothelium. Belongs to the AB hydrolase superfamily. Lipase family. lipoprotein lipase activity triglyceride lipase activity receptor binding calcium ion binding protein binding extracellular region extracellular space plasma membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process heparin binding response to cold response to bacterium cell surface positive regulation of macrophage derived foam cell differentiation positive regulation of cholesterol storage positive regulation of sequestering of triglyceride membrane lipid catabolic process lipase activity hydrolase activity triglyceride binding triglyceride biosynthetic process triglyceride catabolic process cellular response to nutrient apolipoprotein binding very-low-density lipoprotein particle chylomicron remodeling very-low-density lipoprotein particle remodeling response to drug chylomicron cholesterol homeostasis protein homodimerization activity heparan sulfate proteoglycan binding positive regulation of fat cell differentiation metal ion binding positive regulation of interleukin-1 beta secretion positive regulation of inflammatory response carboxylic ester hydrolase activity low-density lipoprotein particle mediated signaling triglyceride homeostasis cellular response to fatty acid lipoprotein particle binding positive regulation of chemokine secretion negative regulation of cellular response to insulin stimulus positive regulation of chemokine (C-C motif) ligand 2 secretion positive regulation of tumor necrosis factor secretion positive regulation of interleukin-6 secretion uc009lwq.1 uc009lwq.2 uc009lwq.3 
ENSMUST00000015719.16 Atp6v0e ENSMUST00000015719.16 ATPase, H+ transporting, lysosomal V0 subunit E (from RefSeq NM_025272.2) Atp6v0e1 ENSMUST00000015719.1 ENSMUST00000015719.10 ENSMUST00000015719.11 ENSMUST00000015719.12 ENSMUST00000015719.13 ENSMUST00000015719.14 ENSMUST00000015719.15 ENSMUST00000015719.2 ENSMUST00000015719.3 ENSMUST00000015719.4 ENSMUST00000015719.5 ENSMUST00000015719.6 ENSMUST00000015719.7 ENSMUST00000015719.8 ENSMUST00000015719.9 NM_025272 Q9CQD8 VA0E1_MOUSE uc008bei.1 uc008bei.2 uc008bei.3 uc008bei.4 uc008bei.5 Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Membrane ; Multi-pass membrane protein Belongs to the V-ATPase e1/e2 subunit family. ion transport hydrogen ion transmembrane transporter activity membrane integral component of membrane hydrolase activity proton-transporting V-type ATPase, V0 domain proton-transporting ATPase activity, rotational mechanism transmembrane transport hydrogen ion transmembrane transport uc008bei.1 uc008bei.2 uc008bei.3 uc008bei.4 uc008bei.5 
ENSMUST00000015723.5 Nkx2-5 ENSMUST00000015723.5 NK2 homeobox 5 (from RefSeq NM_008700.2) ENSMUST00000015723.1 ENSMUST00000015723.2 ENSMUST00000015723.3 ENSMUST00000015723.4 NM_008700 Nkx2-5 Q3UQU2 Q3UQU2_MOUSE uc008beo.1 uc008beo.2 uc008beo.3 Nucleus Belongs to the NK-2 homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding outflow tract septum morphogenesis cardiac conduction system development right ventricular cardiac muscle tissue morphogenesis septum secundum development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter heart development adult heart development transcription factor binding negative regulation of cardiac muscle cell apoptotic process negative regulation of myotube differentiation thyroid gland development macromolecular complex protein-DNA complex sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter spleen development cardiac muscle tissue morphogenesis cardiac muscle contraction ventricular septum morphogenesis atrial septum morphogenesis RNA polymerase II transcription factor complex regulation of cardiac conduction uc008beo.1 uc008beo.2 uc008beo.3 
ENSMUST00000015725.16 Bnip1 ENSMUST00000015725.16 BCL2/adenovirus E1B interacting protein 1 (from RefSeq NM_172149.5) B0V2Q1 Bnip1 ENSMUST00000015725.1 ENSMUST00000015725.10 ENSMUST00000015725.11 ENSMUST00000015725.12 ENSMUST00000015725.13 ENSMUST00000015725.14 ENSMUST00000015725.15 ENSMUST00000015725.2 ENSMUST00000015725.3 ENSMUST00000015725.4 ENSMUST00000015725.5 ENSMUST00000015725.6 ENSMUST00000015725.7 ENSMUST00000015725.8 ENSMUST00000015725.9 NM_172149 Q5M9M2 Q6QD59 SEC20_MOUSE Sec20 Sec20l uc008ben.1 uc008ben.2 uc008ben.3 uc008ben.4 As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization. Also plays a role in apoptosis. It is for instance required for endoplasmic reticulum stress-induced apoptosis. As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy. Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18, RINT1/TIP20L and NAPA. Interacts with ZW10 through RINT1. Interacts with BCL2. Interacts with RNF186. Interacts with RNF185. Interacts with SQSTM1; increased by 'Lys-63'-linked polyubiquitination of BNIP1. Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Mitochondrion membrane ; Single-pass type IV membrane protein Note=Localization to the mitochondrion is regulated by RNF186. Polyubiquitinated. 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1. Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion. Belongs to the SEC20 family. SNAP receptor activity nuclear envelope cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane retrograde vesicle-mediated transport, Golgi to ER apoptotic process endoplasmic reticulum organization protein transport membrane integral component of membrane vesicle-mediated transport endoplasmic reticulum membrane fusion SNARE complex mitochondrial membrane intracellular membrane-bounded organelle uc008ben.1 uc008ben.2 uc008ben.3 uc008ben.4 
ENSMUST00000015749.7 Srf ENSMUST00000015749.7 serum response factor (from RefSeq NM_020493.2) ENSMUST00000015749.1 ENSMUST00000015749.2 ENSMUST00000015749.3 ENSMUST00000015749.4 ENSMUST00000015749.5 ENSMUST00000015749.6 NM_020493 Q9JM73 SRF_MOUSE uc008ctg.1 uc008ctg.2 uc008ctg.3 SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS) (PubMed:24732378). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12732141, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G- actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). Required for cardiac differentiation and maturation (PubMed:15169892). Binds DNA as a multimer, probably a dimer (PubMed:15492011, PubMed:16782067). Interacts with MRTFA, forming the SRF-MRTFA nuclear complex which binds the 5'-CArG-3' consensus motif (CArG box) on DNA via SRF (PubMed:12732141, PubMed:19350017). Forms a nuclear ternary complex with MRTFA and SCAI (PubMed:19350017). Interacts with MRTFB (By similarity). Interacts with MLLT7/FOXO4, NKX3A and SSRP1 (By similarity). Interacts with ARID2 (PubMed:16782067). Interacts with SRFBP1 (PubMed:15492011). Interacts with FOXK1 (By similarity). Interacts with LPXN (By similarity). Interacts with OLFM2; the interaction promotes dissociation of SRF from the transcriptional repressor HEY2, facilitates binding of SRF to target genes and promotes smooth muscle differentiation (By similarity). Interacts with NKX3-1 (PubMed:16814806). Interacts with KAT5 (PubMed:16597624). Q9JM73; Q3U1N2: Srebf2; NbExp=3; IntAct=EBI-493266, EBI-645275; Nucleus Phosphorylated by PRKDC. Mice lacking Srf in cardiac tissue display lethal cardiac defects between 10.5 and 13.5 dpc, characterized by abnormally thin myocardium, dilated cardiac chambers, poor trabeculation and a disorganised interventricular septum. nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding branching involved in blood vessel morphogenesis response to hypoxia in utero embryonic development mesoderm formation neuron migration trophectodermal cell differentiation heart looping morphogenesis of an epithelial sheet cell migration involved in sprouting angiogenesis leukocyte differentiation positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated transcription from RNA polymerase II promoter actin filament organization cell-matrix adhesion multicellular organism development gastrulation heart development long-term memory transcription factor binding negative regulation of cell proliferation associative learning response to hormone epithelial structure maintenance positive regulation of transcription via serum response element binding serum response element binding hippocampus development tangential migration from the subventricular zone to the olfactory bulb actin cytoskeleton organization contractile actin filament bundle assembly regulation of cell adhesion platelet activation platelet formation negative regulation of cell migration thyroid gland development forebrain development neuron projection development chromatin DNA binding regulation of water loss via skin response to cytokine megakaryocyte development dorsal aorta morphogenesis mRNA transcription from RNA polymerase II promoter protein homodimerization activity histone deacetylase binding stress fiber assembly sequence-specific DNA binding skin morphogenesis positive thymic T cell selection sarcomere organization positive regulation of cell differentiation positive regulation of axon extension positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle contraction positive regulation of transcription by glucose muscle cell cellular homeostasis protein dimerization activity thymus development developmental growth erythrocyte development positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of filopodium assembly cardiac myofibril assembly hematopoietic stem cell differentiation positive regulation of transcription initiation from RNA polymerase II promoter long term synaptic depression face development heart trabecula formation lung morphogenesis bronchus cartilage development trachea cartilage development cardiac vascular smooth muscle cell differentiation eyelid development in camera-type eye lung smooth muscle development RNA polymerase II sequence-specific DNA binding transcription factor binding bicellular tight junction assembly primary miRNA binding cellular response to glucose stimulus primitive streak formation epithelial cell-cell adhesion cellular senescence cell-cell adhesion negative regulation of beta-amyloid clearance negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter uc008ctg.1 uc008ctg.2 uc008ctg.3 
ENSMUST00000015771.3 Gata5 ENSMUST00000015771.3 GATA binding protein 5 (from RefSeq NM_008093.2) ENSMUST00000015771.1 ENSMUST00000015771.2 GATA5_MOUSE Gata5 NM_008093 P97489 Q3UQR0 uc008oix.1 uc008oix.2 uc008oix.3 uc008oix.4 Transcription factor required during cardiovascular development (By similarity). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (PubMed:9119112). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity). Nucleus. nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding enhancer sequence-specific DNA binding aortic valve morphogenesis endocardial cushion fusion DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated zinc ion binding negative regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression positive regulation of Notch signaling pathway involved in heart induction sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding cardiac muscle tissue development intestinal epithelial cell differentiation cellular response to BMP stimulus positive regulation of transcription from RNA polymerase II promoter involved in heart development cardiac jelly development uc008oix.1 uc008oix.2 uc008oix.3 uc008oix.4 
ENSMUST00000015791.6 Lama5 ENSMUST00000015791.6 laminin, alpha 5 (from RefSeq NM_001081171.2) A2ABW7 ENSMUST00000015791.1 ENSMUST00000015791.2 ENSMUST00000015791.3 ENSMUST00000015791.4 ENSMUST00000015791.5 LAMA5_MOUSE NM_001081171 Q61001 Q9JHQ6 uc008oip.1 uc008oip.2 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Alpha-5 may be the major laminin alpha chain of adult epithelial and/or endothelial basal laminae. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signaling and PTK2B/PYK2 (By similarity). Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-5 is a subunit of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. In adult, high levels in heart, lung, and kidney; lower in brain, muscle and testis; very low in liver, gut and skin. Expressed in the mesentery lymphatic vessel valves at 15.5 and 18.5 dpc (at protein level). The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. Domains VI, IV and G are globular. branching involved in ureteric bud morphogenesis morphogenesis of a polarized epithelium neural crest cell migration hair follicle development receptor binding integrin binding extracellular matrix structural constituent protein binding extracellular region basement membrane laminin-5 complex extracellular space cell adhesion integrin-mediated signaling pathway muscle organ development animal organ morphogenesis tissue development morphogenesis of embryonic epithelium cell migration regulation of cell adhesion lung development regulation of cell migration extracellular matrix neuromuscular junction substrate adhesion-dependent cell spreading regulation of cell proliferation odontogenesis of dentin-containing tooth synaptic cleft laminin-10 complex regulation of embryonic development branching morphogenesis of an epithelial tube cilium assembly branching involved in salivary gland morphogenesis protein localization to plasma membrane cell-cell adhesion uc008oip.1 uc008oip.2 
ENSMUST00000015796.9 Steap1 ENSMUST00000015796.9 six transmembrane epithelial antigen of the prostate 1 (from RefSeq NM_027399.3) ENSMUST00000015796.1 ENSMUST00000015796.2 ENSMUST00000015796.3 ENSMUST00000015796.4 ENSMUST00000015796.5 ENSMUST00000015796.6 ENSMUST00000015796.7 ENSMUST00000015796.8 NM_027399 Q6P8X4 Q9CWR7 STEA1_MOUSE Steap uc008wjb.1 uc008wjb.2 uc008wjb.3 uc008wjb.4 Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Homotrimer. Endosome membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Belongs to the STEAP family. endosome plasma membrane ion transport endosome membrane membrane integral component of membrane oxidoreductase activity metal ion binding iron ion homeostasis oxidation-reduction process cupric reductase activity copper ion import oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor ferric-chelate reductase (NADPH) activity ferric iron import across plasma membrane uc008wjb.1 uc008wjb.2 uc008wjb.3 uc008wjb.4 
ENSMUST00000015800.16 Hspa8 ENSMUST00000015800.16 heat shock protein 8, transcript variant 1 (from RefSeq NM_031165.5) ENSMUST00000015800.1 ENSMUST00000015800.10 ENSMUST00000015800.11 ENSMUST00000015800.12 ENSMUST00000015800.13 ENSMUST00000015800.14 ENSMUST00000015800.15 ENSMUST00000015800.2 ENSMUST00000015800.3 ENSMUST00000015800.4 ENSMUST00000015800.5 ENSMUST00000015800.6 ENSMUST00000015800.7 ENSMUST00000015800.8 ENSMUST00000015800.9 HSP7C_MOUSE Hsc70 Hsc73 Hspa8 NM_031165 P08109 P12225 P63017 Q3U6R0 Q3U764 Q3U7D7 Q3U7E2 Q3U9B4 Q3U9G0 Q3UGM0 Q5FWJ6 Q62373 Q62374 Q62375 Q6NZD0 uc009ozx.1 uc009ozx.2 uc009ozx.3 uc009ozx.4 uc009ozx.5 Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J- domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Substrate recognition component in chaperone- mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2. KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded. In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.10; Evidence=; Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Interacts with PACRG (By similarity). Interacts with DNAJC7 (By similarity). Interacts with DNAJB12 (via J domain) (By similarity). Interacts with DNAJB14 (via J domain) (By similarity). Interacts (via C-terminus) with the E3 ligase STUB1 forming a 210 kDa complex of one STUB1 and two HSPA8 molecules (By similarity). Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad- mediated transcription transactivation (By similarity). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8 (By similarity). Interacts with IRAK1BP1 and HSPH1/HSP105 (PubMed:9675148, PubMed:15292236, PubMed:17233114). Interacts with TRIM5 (By similarity). Part of a complex composed at least of ASH2L, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity). Following LPS binding, may form a complex with CXCR4, GDF5 and HSP90AA1 (By similarity). Interacts with PRKN (By similarity). Interacts with FOXP3 (By similarity). Interacts with DNAJC9 (via J domain) (By similarity). Interacts with MLLT11 (By similarity). Interacts with RNF207 (By similarity). Interacts with DNAJC21 (By similarity). Interacts with DNAJB2 (By similarity). Interacts with TTC1 (via TPR repeats) (By similarity). Interacts with SGTA (via TPR repeats) (By similarity). Interacts with HSF1 (via transactivation domain) (By similarity). Interacts with HOPX, STUB1, HSP40, HSP90, BAG2 and BAG3 (By similarity). Interacts with DNAJC12 (By similarity). Interacts with HSPC138 (By similarity). Interacts with ZMYND10 (By similarity). Interacts with VGF-derived peptide TLQP-21 (By similarity). Interacts with BCL2L1, GIMAP5 and MCL1; the interaction with BCL2L1 or MCL1 is impaired in the absence of GIMAP5 (PubMed:21502331). Interacts with NLPR12 (By similarity). Interacts with TTC4 (By similarity). Interacts with TOMM70; the interaction is required for preprotein mitochondrial import (By similarity). May interact with DNJC9; the interaction seems to be histone-dependent (By similarity). Interacts with BAG5 and JPH2; the interaction with JPH2 is increased in the presence of BAG5 (By similarity). Interacts with VGF- derived peptide TLQP-21 (By similarity). P63017; O88447: Klc1; NbExp=3; IntAct=EBI-433443, EBI-301550; P63017; P43883: Plin2; NbExp=3; IntAct=EBI-433443, EBI-16156700; P63017; Q9DBG5: Plin3; NbExp=2; IntAct=EBI-433443, EBI-643495; P63017; O41974: GAMMAHV.ORF73; Xeno; NbExp=3; IntAct=EBI-433443, EBI-6933128; Cytoplasm Melanosome Nucleus, nucleolus Cell membrane Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Ubiquitous. Constitutively synthesized. The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide- binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins. Acetylated. ISGylated. Trimethylation at Lys-561 reduces fibrillar SNCA binding. Belongs to the heat shock protein 70 family. Sequence=BAE31508.1; Type=Frameshift; Evidence=; nucleotide binding Prp19 complex G-protein coupled receptor binding phosphatidylserine binding positive regulation of T cell mediated cytotoxicity photoreceptor inner segment RNA binding receptor binding protein binding ATP binding nucleus spliceosomal complex nucleolus cytoplasm lysosome lysosomal membrane late endosome autophagosome cytosol microtubule intermediate filament plasma membrane mRNA processing protein folding protein import into nucleus response to unfolded protein synaptic vesicle axo-dendritic transport transcription factor binding RNA splicing cell surface positive regulation of gene expression negative regulation of cardiac muscle cell apoptotic process postsynaptic density membrane vesicle-mediated transport ATPase activity enzyme binding axon dendrite protein binding, bridging heat shock protein binding ubiquitin protein ligase binding regulation of protein stability A1 adenosine receptor binding asymmetric synapse macromolecular complex cellular response to heat cellular response to unfolded protein protein refolding peptide binding melanosome ATPase activity, coupled neuron projection neuronal cell body positive regulation of catalytic activity terminal bouton dendritic spine dendritic shaft perikaryon myelin sheath ADP binding cellular protein complex disassembly protein binding involved in protein folding neuron spine modulation by host of viral process positive regulation by host of viral genome replication membrane raft positive regulation of proteolysis negative regulation of transcription, DNA-templated ATP metabolic process protein autophosphorylation positive regulation of mRNA splicing, via spliceosome perinuclear region of cytoplasm positive regulation of phagocytosis unfolded protein binding chaperone mediated protein folding requiring cofactor chaperone binding regulation of cell cycle misfolded protein binding C3HC4-type RING finger domain binding chaperone-mediated protein folding regulation of protein complex stability chaperone-mediated autophagy late endosomal microautophagy protein targeting to lysosome involved in chaperone-mediated autophagy chaperone-mediated protein transport involved in chaperone-mediated autophagy extracellular exosome clathrin coat disassembly positive regulation of lysosomal membrane permeability presynapse postsynapse maintenance of postsynaptic specialization structure glutamatergic synapse presynaptic cytosol postsynaptic cytosol postsynaptic specialization membrane negative regulation of supramolecular fiber organization positive regulation of protein refolding prostaglandin binding chaperone-mediated autophagy translocation complex disassembly messenger ribonucleoprotein complex slow axonal transport clathrin-uncoating ATPase activity lysosomal matrix ribonucleoprotein complex uc009ozx.1 uc009ozx.2 uc009ozx.3 uc009ozx.4 uc009ozx.5 
ENSMUST00000015812.12 Pdzd11 ENSMUST00000015812.12 Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. (from UniProt Q9CZG9) BC022181 ENSMUST00000015812.1 ENSMUST00000015812.10 ENSMUST00000015812.11 ENSMUST00000015812.2 ENSMUST00000015812.3 ENSMUST00000015812.4 ENSMUST00000015812.5 ENSMUST00000015812.6 ENSMUST00000015812.7 ENSMUST00000015812.8 ENSMUST00000015812.9 PDZ11_MOUSE Pdzk11 Q9CZG9 uc009twf.1 uc009twf.2 uc009twf.3 Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. Interacts with ATP2B1, ATP2B2, ATP2B3, ATP2B4 and ATP7A (By similarity). Interacts with PLEKHA7 (via WW domains) at zonula adherens; this interaction is essential for the interaction between PLEKHA7 and the ADAM10-binding protein TSPAN33 (PubMed:30463011). Interacts with SLC5A6 (By similarity). Cytoplasm Cell junction, adherens junction Cell membrane cytoplasm cytosol plasma membrane cell-cell junction adherens junction neurotransmitter secretion protein C-terminus binding membrane basolateral plasma membrane cell junction maintenance of epithelial cell apical/basal polarity synapse pore complex pore complex assembly presynapse protein localization to basolateral plasma membrane uc009twf.1 uc009twf.2 uc009twf.3 
ENSMUST00000015829.15 Acadsb ENSMUST00000015829.15 acyl-Coenzyme A dehydrogenase, short/branched chain (from RefSeq NM_025826.4) ACDSB_MOUSE Acadsb ENSMUST00000015829.1 ENSMUST00000015829.10 ENSMUST00000015829.11 ENSMUST00000015829.12 ENSMUST00000015829.13 ENSMUST00000015829.14 ENSMUST00000015829.2 ENSMUST00000015829.3 ENSMUST00000015829.4 ENSMUST00000015829.5 ENSMUST00000015829.6 ENSMUST00000015829.7 ENSMUST00000015829.8 ENSMUST00000015829.9 NM_025826 Q9DBL1 uc009kbm.1 uc009kbm.2 uc009kbm.3 uc009kbm.4 Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the removal of one hydrogen from C-2 and C-3 of the fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (By similarity). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2- methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway (By similarity). Can also act on valproyl-CoA, a metabolite of the valproic acid drug (By similarity). Reaction=2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:43780, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57336, ChEBI:CHEBI:57337, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307; EC=1.3.8.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43781; Evidence=; Reaction=(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:48256, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57337, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:88166; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48257; Evidence=; Reaction=(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:65296, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:156439, ChEBI:CHEBI:156440; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65297; Evidence=; Reaction=butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:24004, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57332, ChEBI:CHEBI:57371, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24005; Evidence=; Reaction=2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylpropenoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:44180, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57338, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:62500; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44181; Evidence=; Reaction=H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:43464, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:62077, ChEBI:CHEBI:62620; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43465; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + valproyl- CoA = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:65344, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:156457, ChEBI:CHEBI:156458; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65345; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Lipid metabolism; mitochondrial fatty acid beta-oxidation. Amino-acid degradation; L-isoleucine degradation. Homotetramer. Mitochondrion matrix Belongs to the acyl-CoA dehydrogenase family. acyl-CoA dehydrogenase activity mitochondrion mitochondrial matrix lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process electron carrier activity oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors short-branched-chain-acyl-CoA dehydrogenase activity electron transport chain flavin adenine dinucleotide binding oxidation-reduction process uc009kbm.1 uc009kbm.2 uc009kbm.3 uc009kbm.4 
ENSMUST00000015846.9 Anxa9 ENSMUST00000015846.9 annexin A9, transcript variant 2 (from RefSeq NM_023628.3) ANXA9_MOUSE ENSMUST00000015846.1 ENSMUST00000015846.2 ENSMUST00000015846.3 ENSMUST00000015846.4 ENSMUST00000015846.5 ENSMUST00000015846.6 ENSMUST00000015846.7 ENSMUST00000015846.8 NM_023628 Q9CQS1 Q9JHQ0 uc008qjh.1 uc008qjh.2 uc008qjh.3 uc008qjh.4 May act as a low affinity receptor for acetylcholine. Homodimer. Belongs to the annexin family. Sequence=CAB95698.1; Type=Frameshift; Evidence=; angiogenesis membrane raft assembly phosphatidylserine binding positive regulation of receptor recycling positive regulation of protein phosphorylation protease binding growth plate cartilage development calcium channel activity calcium ion binding phospholipid binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding extracellular space nucleus cytoplasm cytosol plasma membrane membrane budding synaptic transmission, cholinergic cell surface regulation of plasminogen activation acetylcholine receptor activity Rab GTPase binding phospholipase A2 inhibitor activity collagen fibril organization biomineral tissue development positive regulation of vesicle fusion vesicle positive regulation of chondrocyte differentiation negative regulation of low-density lipoprotein particle receptor catabolic process osteoclast development fibrinolysis identical protein binding negative regulation of catalytic activity positive regulation of vacuole organization negative regulation of development of symbiont involved in interaction with host S100 protein binding bone sialoprotein binding virion binding positive regulation of fibroblast proliferation protein heterotetramerization regulation of cytosolic calcium ion concentration positive regulation of calcium ion transport catabolism by host of symbiont protein negative regulation by host of symbiont molecular function endocardial cell differentiation calcium ion transmembrane transport protein localization to plasma membrane cell-cell adhesion voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels positive regulation of low-density lipoprotein particle clearance positive regulation of low-density lipoprotein particle receptor binding positive regulation of low-density lipoprotein receptor activity positive regulation of receptor-mediated endocytosis involved in cholesterol transport uc008qjh.1 uc008qjh.2 uc008qjh.3 uc008qjh.4 
ENSMUST00000015855.8 Prune1 ENSMUST00000015855.8 prune exopolyphosphatase (from RefSeq NM_173347.2) ENSMUST00000015855.1 ENSMUST00000015855.2 ENSMUST00000015855.3 ENSMUST00000015855.4 ENSMUST00000015855.5 ENSMUST00000015855.6 ENSMUST00000015855.7 NM_173347 PRUN1_MOUSE Prune Q80VU0 Q8BIW1 uc008qiz.1 uc008qiz.2 Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization. Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474; EC=3.6.1.1; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; Activated by magnesium ions and inhibited by manganese ions. Inhibited by dipyridamole, moderately sensitive to IBMX and inhibited by vinpocetine (By similarity). Homooligomer. Able to homodimerize via its C-terminal domain. Interacts with NME1. Interacts with GSK3; at focal adhesion complexes where paxillin and vinculin are colocalized. Interacts with alpha and beta tubulin. Cytoplasm Nucleus Cell junction, focal adhesion In the developing embryo, a high level of expression is confined to the nervous system particularly in the dorsal root ganglia, cranial nerves, and neural retina. From 10.5 dpc, expressed at low levels in the basal plate along the entire neural tube, while at 12.5 dpc the expression in the nervous system is definitively stronger, especially in the cranial and dorsal root ganglia and in the spinal nerves. In the hypothalamus, the expression is confined to the retro-chiasmatic area (RCH) and is also detectable in the remnant of the Rathke's pouch. In the developing eye, exclusively expressed in the prospective neural retina, equally distributed in both the deep and superficial layers. At 16.5 dpc, expression is still detectable in the outer neuroblast layer of the neural retina. Belongs to the PPase class C family. Prune subfamily. exopolyphosphatase activity inorganic diphosphatase activity nucleus cytoplasm cytosol focal adhesion polyphosphate catabolic process tubulin binding dephosphorylation pyrophosphatase activity hydrolase activity phosphatase activity cell junction regulation of microtubule polymerization metal ion binding regulation of neurogenesis uc008qiz.1 uc008qiz.2 
ENSMUST00000015858.12 Cers2 ENSMUST00000015858.12 ceramide synthase 2, transcript variant 1 (from RefSeq NM_029789.2) CERS2_MOUSE Cers2 ENSMUST00000015858.1 ENSMUST00000015858.10 ENSMUST00000015858.11 ENSMUST00000015858.2 ENSMUST00000015858.3 ENSMUST00000015858.4 ENSMUST00000015858.5 ENSMUST00000015858.6 ENSMUST00000015858.7 ENSMUST00000015858.8 ENSMUST00000015858.9 Lass2 NM_029789 Q3TXC5 Q924Z4 Q9DCN6 Trh3 uc008qjj.1 uc008qjj.2 uc008qjj.3 uc008qjj.4 Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27) (PubMed:15823095, PubMed:18165233, PubMed:20110363, PubMed:23275342). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:15823095, PubMed:18165233, PubMed:20110363, PubMed:23275342). Plays a non-redundant role in the synthesis of ceramides with very- long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions (PubMed:19801672, PubMed:32279995). Reaction=a sphingoid base + a very long-chain fatty acyl-CoA = an N- (very-long-chain fatty acyl)-sphingoid base + CoA + H(+); Xref=Rhea:RHEA:61480, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:84410, ChEBI:CHEBI:138261, ChEBI:CHEBI:144712; EC=2.3.1.297; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61481; Evidence= Reaction=docosanoyl-CoA + sphinganine = CoA + H(+) + N- docosanoylsphinganine; Xref=Rhea:RHEA:36535, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:65059, ChEBI:CHEBI:67021; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36536; Evidence= Reaction=sphinganine + tetracosanoyl-CoA = CoA + H(+) + N- tetracosanoylsphinganine; Xref=Rhea:RHEA:33591, ChEBI:CHEBI:15378, ChEBI:CHEBI:52961, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:65052; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33592; Evidence=; Reaction=hexacosanoyl-CoA + sphinganine = CoA + H(+) + N- hexacosanoylsphinganine; Xref=Rhea:RHEA:33351, ChEBI:CHEBI:15378, ChEBI:CHEBI:52962, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:64868; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33352; Evidence= Reaction=(15Z)-tetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(15Z- tetracosenoyl)-sphinganine; Xref=Rhea:RHEA:36667, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:74128, ChEBI:CHEBI:74130; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36668; Evidence=; Reaction=2-hydroxytetracosanoyl-CoA + sphinganine = CoA + H(+) + N-(2- hydroxytetracosanoyl)-sphinganine; Xref=Rhea:RHEA:36627, ChEBI:CHEBI:15378, ChEBI:CHEBI:52371, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:74118; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36628; Evidence=; Reaction=2-hydroxydocosanoyl-CoA + sphinganine = CoA + H(+) + N-(2- hydroxydocosanoyl)-sphinganine; Xref=Rhea:RHEA:36619, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:67023, ChEBI:CHEBI:74117; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36620; Evidence=; Reaction=2-hydroxytetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(2- hydroxytetracosenoyl)-sphinganine; Xref=Rhea:RHEA:36767, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:74215, ChEBI:CHEBI:74216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36768; Evidence=; Reaction=sphinganine + tetracosenoyl-CoA = an N- tetracosenoylsphinganine + CoA + H(+); Xref=Rhea:RHEA:36715, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:74146, ChEBI:CHEBI:74160; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36716; Evidence=; Reaction=hexacosenoyl-CoA + sphinganine = CoA + H(+) + N- hexacosenoylsphinganine; Xref=Rhea:RHEA:36719, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:74161, ChEBI:CHEBI:74162; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36720; Evidence=; Reaction=sphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N- tetracosanoyl-sphing-4-enine; Xref=Rhea:RHEA:37115, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57756, ChEBI:CHEBI:65052, ChEBI:CHEBI:72965; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37116; Evidence=; Reaction=sphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N- (tetracosenoyl)-sphing-4-enine; Xref=Rhea:RHEA:37123, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57756, ChEBI:CHEBI:74146, ChEBI:CHEBI:74457; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37124; Evidence=; Reaction=heptadecasphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N- tetracosanoyl-heptadecasphing-4-enine; Xref=Rhea:RHEA:36739, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:74166, ChEBI:CHEBI:74167; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36740; Evidence=; Reaction=a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+); Xref=Rhea:RHEA:23768, ChEBI:CHEBI:15378, ChEBI:CHEBI:52639, ChEBI:CHEBI:57287, ChEBI:CHEBI:57756, ChEBI:CHEBI:77636; EC=2.3.1.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23769; Evidence=; Reaction=hexadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N- hexadecanoylsphing-4-enine; Xref=Rhea:RHEA:36687, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57756, ChEBI:CHEBI:72959; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36688; Evidence=; Reaction=octadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N- octadecanoylsphing-4-enine; Xref=Rhea:RHEA:36691, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57756, ChEBI:CHEBI:72961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36692; Evidence=; Reaction=eicosanoyl-CoA + sphing-4-enine = CoA + H(+) + N-eicosanoyl- sphing-4-enine; Xref=Rhea:RHEA:45284, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:57756, ChEBI:CHEBI:72962; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45285; Evidence=; Reaction=hexadecanoyl-CoA + sphinganine = CoA + H(+) + N- hexadecanoylsphinganine; Xref=Rhea:RHEA:36539, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57817, ChEBI:CHEBI:67042; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36540; Evidence=; Reaction=octadecanoyl-CoA + sphinganine = CoA + H(+) + N- (octadecanoyl)-sphinganine; Xref=Rhea:RHEA:36547, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57817, ChEBI:CHEBI:67033; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36548; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + sphinganine = CoA + H(+) + N-(9Z- octadecenoyl)-sphinganine; Xref=Rhea:RHEA:36575, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57817, ChEBI:CHEBI:74100; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36576; Evidence=; Reaction=eicosanoyl-CoA + sphinganine = CoA + H(+) + N- eicosanoylsphinganine; Xref=Rhea:RHEA:36555, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:57817, ChEBI:CHEBI:67027; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36556; Evidence=; Ceramide synthase activity is inhibited by sphingosine-1-phosphate. Lipid metabolism; sphingolipid metabolism. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR (By similarity). Interacts with NDUFS2 (PubMed:32279995). Endoplasmic reticulum membrane ; Multi-pass membrane protein Broadly expressed, with highest levels in liver and kidney (PubMed:15823095, PubMed:18165233, PubMed:19801672). In brain is detected in neurons, oligodentrocytes, ependymal cells and epithelial cells of the choroid plexus. In kidney is detected in collecting ducts and to a lesser degree in proximal tubules. The last loop motif confers selectivity toward behenoyl-CoA (docosanoyl-CoA; C22:0-CoA) and lignoceroyl-CoA (tetracosanoyl-CoA; C24:0-CoA) as acyl donors. Acetylated (PubMed:26620563). Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation (PubMed:26620563). Phosphorylated at the C-terminus by CK2, leading to increase the ceramide synthase activity. Most mice do not survive beyond 16 months (PubMed:20110363). Ceramide and downstream sphingolipids are devoid of very long (C22-C24) acyl chains (PubMed:20110363). Total glycerophospholipid and cholesterol levels are unaltered, while a marked increase in C18:1 and C18:2 fatty acids in phosphatidylethanolamine, concomitant with a reduction in C18:0 and C20:4 fatty acids are observed (PubMed:20110363). Membranes display higher membrane fluidity and show morphological changes (PubMed:20110363). Mutant mice show signs of neurodegeneration characterized by the loss of myelin sheath structure stability and formation of numerous small cysts in the cerebellum. They develop hepatocarcinomas between 7 and 9 months of age. Contains a predicted homeobox domain which is degenerated and lacks residues that are important for DNA-binding. The protein localizes in the endoplasmic reticulum and not in the nucleus, which also argues against homeobox function (PubMed:15823095). DNA binding protein binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process sphingolipid metabolic process membrane integral component of membrane transferase activity sphingolipid biosynthetic process ceramide biosynthetic process negative regulation of axon regeneration sphingosine N-acyltransferase activity negative regulation of Schwann cell migration negative regulation of Schwann cell proliferation involved in axon regeneration uc008qjj.1 uc008qjj.2 uc008qjj.3 uc008qjj.4 
ENSMUST00000015877.14 Capza2 ENSMUST00000015877.14 capping actin protein of muscle Z-line subunit alpha 2 (from RefSeq NM_007604.3) Capza2 ENSMUST00000015877.1 ENSMUST00000015877.10 ENSMUST00000015877.11 ENSMUST00000015877.12 ENSMUST00000015877.13 ENSMUST00000015877.2 ENSMUST00000015877.3 ENSMUST00000015877.4 ENSMUST00000015877.5 ENSMUST00000015877.6 ENSMUST00000015877.7 ENSMUST00000015877.8 ENSMUST00000015877.9 NM_007604 Q5DQJ3 Q5DQJ3_MOUSE uc009azt.1 uc009azt.2 uc009azt.3 uc009azt.4 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Heterodimer of an alpha and a beta subunit. Belongs to the F-actin-capping protein alpha subunit family. actin binding F-actin capping protein complex barbed-end actin filament capping actin filament capping uc009azt.1 uc009azt.2 uc009azt.3 uc009azt.4 
ENSMUST00000015889.10 Plekho1 ENSMUST00000015889.10 pleckstrin homology domain containing, family O member 1, transcript variant 1 (from RefSeq NM_023320.3) ENSMUST00000015889.1 ENSMUST00000015889.2 ENSMUST00000015889.3 ENSMUST00000015889.4 ENSMUST00000015889.5 ENSMUST00000015889.6 ENSMUST00000015889.7 ENSMUST00000015889.8 ENSMUST00000015889.9 NM_023320 PKHO1_MOUSE Q9CXH2 Q9JIY0 uc008qlx.1 uc008qlx.2 uc008qlx.3 uc008qlx.4 uc008qlx.5 Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity). Heterodimer or homodimer. Interacts with CK2 and actin capping subunits (capping protein CP-alpha and CP-beta). CKIP1 and CK2 together inhibit the activity of actin capping protein at the barbed ends of actin filaments. Interacts with ATM, IFP35, JUN, JUND, NMI and PI3K. Interacts with AKT1, AKT2 and AKT3 (each isozyme of PKB), PtdIns(3,5)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P2 (By similarity). Cell membrane ; Peripheral membrane protein Nucleus Cytoplasm Note=Predominantly localized to the plasma membrane through the binding to phosphatidylinositol 3- phosphate. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells. C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage. protein binding nucleus cytoplasm plasma membrane myoblast fusion regulation of cell shape membrane ruffle membrane muscle cell projection membrane myoblast migration lamellipodium morphogenesis uc008qlx.1 uc008qlx.2 uc008qlx.3 uc008qlx.4 uc008qlx.5 
ENSMUST00000015891.6 Vps45 ENSMUST00000015891.6 vacuolar protein sorting 45 (from RefSeq NM_013841.3) ENSMUST00000015891.1 ENSMUST00000015891.2 ENSMUST00000015891.3 ENSMUST00000015891.4 ENSMUST00000015891.5 NM_013841 P97390 Q91VK9 VPS45_MOUSE Vps45a uc008qly.1 uc008qly.2 uc008qly.3 uc008qly.4 May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network. Interacts with ZFYVE20 (By similarity). Interacts with STX6. Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Associated with Golgi/endosomal vesicles and the trans-Golgi network. Belongs to the STXBP/unc-18/SEC1 family. Golgi membrane protein binding endosome Golgi apparatus vesicle docking involved in exocytosis synaptic vesicle biological_process endosome membrane protein transport membrane integral component of membrane vesicle-mediated transport uc008qly.1 uc008qly.2 uc008qly.3 uc008qly.4 
ENSMUST00000015892.14 Prpf3 ENSMUST00000015892.14 pre-mRNA processing factor 3, transcript variant 3 (from RefSeq NR_151629.1) ENSMUST00000015892.1 ENSMUST00000015892.10 ENSMUST00000015892.11 ENSMUST00000015892.12 ENSMUST00000015892.13 ENSMUST00000015892.2 ENSMUST00000015892.3 ENSMUST00000015892.4 ENSMUST00000015892.5 ENSMUST00000015892.6 ENSMUST00000015892.7 ENSMUST00000015892.8 ENSMUST00000015892.9 NR_151629 PRPF3_MOUSE Q3TJH4 Q922U1 Q9D6C6 uc008qlg.1 uc008qlg.2 uc008qlg.3 uc008qlg.4 Plays a role in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). Component of the precatalytic spliceosome (spliceosome B complex) (By similarity). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (By similarity). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity). Interacts directly with PRPF4 (By similarity). Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA (By similarity). Interacts with SART3; the interaction is direct and recruits the deubiquitinase USP4 to PRPF3 (By similarity). Interacts with PRPF19 (By similarity). Interacts ('Lys- 63'-linked polyubiquitinated) with PRPF8 (via the MPN (JAB/Mov34) domain); may stabilize the U4/U6-U5 tri-snRNP complex (By similarity). Interacts with ERCC6 (By similarity). Nucleus Nucleus speckle Ubiquitinated. Undergoes 'Lys-63'-linked polyubiquitination by PRPF19 and deubiquitination by USP4. 'Lys-63'-linked ubiquitination increases the affinity for PRPF8 and may regulate the assembly of the U4/U6-U5 tri-snRNP complex. spliceosomal tri-snRNP complex assembly mRNA splicing, via spliceosome nucleus nucleoplasm spliceosomal complex cytosol mRNA processing RNA splicing Cajal body nuclear speck macromolecular complex identical protein binding U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome uc008qlg.1 uc008qlg.2 uc008qlg.3 uc008qlg.4 
ENSMUST00000015901.11 Ppil4 ENSMUST00000015901.11 peptidylprolyl isomerase (cyclophilin)-like 4 (from RefSeq NM_026141.3) ENSMUST00000015901.1 ENSMUST00000015901.10 ENSMUST00000015901.2 ENSMUST00000015901.3 ENSMUST00000015901.4 ENSMUST00000015901.5 ENSMUST00000015901.6 ENSMUST00000015901.7 ENSMUST00000015901.8 ENSMUST00000015901.9 NM_026141 PPIL4_MOUSE Q3TJX1 Q68FC7 Q9CT22 Q9CXG3 uc007eip.1 uc007eip.2 uc007eip.3 uc007eip.4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Nucleus Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily. protein peptidyl-prolyl isomerization nucleic acid binding RNA binding peptidyl-prolyl cis-trans isomerase activity nucleus nucleoplasm cytosol isomerase activity regulation of phosphorylation of RNA polymerase II C-terminal domain uc007eip.1 uc007eip.2 uc007eip.3 uc007eip.4 
ENSMUST00000015903.12 Cnih1 ENSMUST00000015903.12 cornichon family AMPA receptor auxiliary protein 1, transcript variant 1 (from RefSeq NM_009919.2) CNIH1_MOUSE Cnih ENSMUST00000015903.1 ENSMUST00000015903.10 ENSMUST00000015903.11 ENSMUST00000015903.2 ENSMUST00000015903.3 ENSMUST00000015903.4 ENSMUST00000015903.5 ENSMUST00000015903.6 ENSMUST00000015903.7 ENSMUST00000015903.8 ENSMUST00000015903.9 NM_009919 O35372 Q6ZWW6 uc007thg.1 uc007thg.2 uc007thg.3 uc007thg.4 uc007thg.5 uc007thg.6 Involved in the selective transport and maturation of TGF- alpha family proteins. Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking full N-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55 and transmembrane TGFA (By similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane. Note=Located primarily in the ER; may cycle between the ER and the Golgi apparatus. Expressed in oocytes, and at a basal level in ovarian somatic cells of 6-week-old mouse. Expressed in adult brain. Abundant in full grown oocyte and the ovulated unfertilized egg, shows a slight decrease 12 hours after fertilization. Transcripts from the activated embryonic genome are present in the eight-cell embryo. Belongs to the cornichon family. Golgi membrane molecular_function cellular_component endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus biological_process membrane integral component of membrane vesicle-mediated transport uc007thg.1 uc007thg.2 uc007thg.3 uc007thg.4 uc007thg.5 uc007thg.6 
ENSMUST00000015920.12 Med22 ENSMUST00000015920.12 mediator complex subunit 22, transcript variant 5 (from RefSeq NM_001378788.1) A2ALA2 ENSMUST00000015920.1 ENSMUST00000015920.10 ENSMUST00000015920.11 ENSMUST00000015920.2 ENSMUST00000015920.3 ENSMUST00000015920.4 ENSMUST00000015920.5 ENSMUST00000015920.6 ENSMUST00000015920.7 ENSMUST00000015920.8 ENSMUST00000015920.9 MED22_MOUSE NM_001378788 Q3TTZ9 Q62276 Surf5 uc008iwd.1 uc008iwd.2 uc008iwd.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Surf5B; IsoId=Q62276-1; Sequence=Displayed; Name=2; Synonyms=Surf5A; IsoId=Q62276-2; Sequence=VSP_028993, VSP_028994; Belongs to the Mediator complex subunit 22 family. transcription cofactor activity nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter mediator complex uc008iwd.1 uc008iwd.2 uc008iwd.3 
ENSMUST00000015934.13 Surf1 ENSMUST00000015934.13 surfeit gene 1, transcript variant 1 (from RefSeq NM_013677.2) ENSMUST00000015934.1 ENSMUST00000015934.10 ENSMUST00000015934.11 ENSMUST00000015934.12 ENSMUST00000015934.2 ENSMUST00000015934.3 ENSMUST00000015934.4 ENSMUST00000015934.5 ENSMUST00000015934.6 ENSMUST00000015934.7 ENSMUST00000015934.8 ENSMUST00000015934.9 NM_013677 P09925 Q99KB4 Q9DCU5 SURF1_MOUSE Surf-1 uc012bsq.1 uc012bsq.2 uc012bsq.3 Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex (By similarity). Regulates cytochrome c oxidase assembly (PubMed:17210671, PubMed:23838831, PubMed:24911525). Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14. Interacts with COA3. Mitochondrion membrane ; Multi-pass membrane protein Results in smaller animals with mild decreased motor skills, enhanced working spatial and recognition memory, and increased longevity (PubMed:17210671, PubMed:23838831, PubMed:24911525). Increases global and regional cerebral blood flow (PubMed:23838831). Increases lactate levels in blood and brain, and increases glucose consumption in the brain (PubMed:17210671, PubMed:23838831, PubMed:24911525). Increases hydrogen peroxide production and succinate dehydrogenase (SDH) activity, but decreases COX activity and respiration (PubMed:17210671, PubMed:21167962, PubMed:23838831, PubMed:24911525). In the brain, increases Hif1a and phosphorylated cyclic AMP response element-binding protein levels (PubMed:23838831). In the brain, increases resistance to calcium- related excitotoxic brain damage (PubMed:17210671). In skeletal muscles, results in mitochondrial unfolded protein response (PubMed:24911525). In the heart, results in elevated Nfe2l2 and Hmox1 expression (PubMed:24911525). Primary cultures of mutant neuronal cells show reduced sensitivity to glutamate-induced cytosolic calcium signal and impaired mitochondrial calcium uptake without changing the mitochondrial structure and membrane potential (PubMed:17210671). Primary cultures of phrenic and central vagus nerves show increased respiratory frequency and altered response to systemic hypoxia and hypercapnia (PubMed:21167962). Belongs to the SURF1 family. cytochrome-c oxidase activity mitochondrion mitochondrial inner membrane oxidative phosphorylation membrane integral component of membrane electron transport chain mitochondrial respiratory chain complex IV assembly hydrogen ion transmembrane transport uc012bsq.1 uc012bsq.2 uc012bsq.3 
ENSMUST00000015941.8 Bhmt2 ENSMUST00000015941.8 betaine-homocysteine methyltransferase 2 (from RefSeq NM_022884.2) B1B1C9 BHMT2_MOUSE ENSMUST00000015941.1 ENSMUST00000015941.2 ENSMUST00000015941.3 ENSMUST00000015941.4 ENSMUST00000015941.5 ENSMUST00000015941.6 ENSMUST00000015941.7 NM_022884 Q8C1U2 Q91WS4 Q9EQE8 uc007rlk.1 uc007rlk.2 uc007rlk.3 Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. Reaction=L-homocysteine + S-methyl-L-methionine = H(+) + 2 L- methionine; Xref=Rhea:RHEA:26337, ChEBI:CHEBI:15378, ChEBI:CHEBI:57844, ChEBI:CHEBI:58199, ChEBI:CHEBI:58252; EC=2.1.1.10; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. Homotetramer. Expressed in fetal heart, lung, liver, kidney and eye. methyltransferase activity zinc ion binding S-adenosylmethionine-homocysteine S-methyltransferase activity methionine biosynthetic process transferase activity methylation S-methylmethionine metabolic process S-adenosylmethionine metabolic process metal ion binding betaine-homocysteine S-methyltransferase activity S-methylmethionine-homocysteine S-methyltransferase activity L-methionine salvage uc007rlk.1 uc007rlk.2 uc007rlk.3 
ENSMUST00000015950.12 Qdpr ENSMUST00000015950.12 quinoid dihydropteridine reductase (from RefSeq NM_024236.2) DHPR_MOUSE Dhpr ENSMUST00000015950.1 ENSMUST00000015950.10 ENSMUST00000015950.11 ENSMUST00000015950.2 ENSMUST00000015950.3 ENSMUST00000015950.4 ENSMUST00000015950.5 ENSMUST00000015950.6 ENSMUST00000015950.7 ENSMUST00000015950.8 ENSMUST00000015950.9 NM_024236 Q3TT09 Q8BVI4 Q9D0K4 uc008xix.1 uc008xix.2 uc008xix.3 uc008xix.4 Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin. Reaction=5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + H(+) + NADH; Xref=Rhea:RHEA:17869, ChEBI:CHEBI:15378, ChEBI:CHEBI:28889, ChEBI:CHEBI:30156, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.5.1.34; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17871; Evidence=; Reaction=5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + H(+) + NADPH; Xref=Rhea:RHEA:17865, ChEBI:CHEBI:15378, ChEBI:CHEBI:28889, ChEBI:CHEBI:30156, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.34; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17867; Evidence=; Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family. liver development 6,7-dihydropteridine reductase activity cytoplasm mitochondrion cytosol L-phenylalanine catabolic process tetrahydrobiopterin biosynthetic process response to aluminum ion response to lead ion oxidoreductase activity response to glucagon cellular response to drug protein homodimerization activity neuron projection oxidation-reduction process NADPH binding NADH binding uc008xix.1 uc008xix.2 uc008xix.3 uc008xix.4 
ENSMUST00000015987.10 Rxrg ENSMUST00000015987.10 retinoid X receptor gamma, transcript variant 1 (from RefSeq NM_009107.4) ENSMUST00000015987.1 ENSMUST00000015987.2 ENSMUST00000015987.3 ENSMUST00000015987.4 ENSMUST00000015987.5 ENSMUST00000015987.6 ENSMUST00000015987.7 ENSMUST00000015987.8 ENSMUST00000015987.9 NM_009107 Nr2b3 P28705 RXRG_MOUSE uc007dla.1 uc007dla.2 uc007dla.3 uc007dla.4 Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). Homodimer (By similarity). Heterodimer with a RAR molecule (By similarity). Binds DNA preferentially as a RAR/RXR heterodimer (By similarity). Interacts with RARA (By similarity). Nucleus Cytoplasm Expressed from embryo day 10.5 to birth. At day 10-13, expression in somites and the ventral horns of the spinal chord. At day 13.5, strongly expressed in the corpus striatum. At day 16.5, expression also in the pituitary with weaker expression in the neck, skeletal muscle and tongue. Expression in the corpus striatum continues until at least 7 days after birth. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Acetylated by EP300. Knockout mice exhibit memory deficits. Belongs to the nuclear hormone receptor family. NR2 subfamily. RNA polymerase II regulatory region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter zinc ion binding cell differentiation regulation of myelination response to retinoic acid identical protein binding steroid hormone mediated signaling pathway sequence-specific DNA binding retinoic acid-responsive element binding positive regulation of transcription from RNA polymerase II promoter metal ion binding retinoic acid receptor signaling pathway anatomical structure development RNA polymerase II transcription factor complex positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus uc007dla.1 uc007dla.2 uc007dla.3 uc007dla.4 
ENSMUST00000015998.8 Cd5l ENSMUST00000015998.8 CD5 antigen-like (from RefSeq NM_009690.2) Aim Api6 CD5L_MOUSE ENSMUST00000015998.1 ENSMUST00000015998.2 ENSMUST00000015998.3 ENSMUST00000015998.4 ENSMUST00000015998.5 ENSMUST00000015998.6 ENSMUST00000015998.7 NM_009690 O35300 O35301 Q3TXN5 Q505P6 Q91W05 Q9QWK4 uc008psa.1 uc008psa.2 uc008psa.3 uc008psa.4 Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis (PubMed:26048980). Able to inhibit lipid droplet size in adipocytes (PubMed:20519120, PubMed:22579686). Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA) (PubMed:20519120). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease (PubMed:21730133). Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC) (PubMed:22579686, PubMed:26607793). Acts as a key regulator of metabolic switch in T-helper Th17 cells (PubMed:26607794, PubMed:26607793). Regulates the expression of pro- inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation (PubMed:26607793). CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes (PubMed:26607793). Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (PubMed:23562157). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:9892623, PubMed:16054063). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (By similarity). Interacts with FASN; the interaction is direct (PubMed:20519120). Interacts (via SRCR2 and SRCR3) with pentameric IgM (via Fc region); disulfide-linked (PubMed:23562157, PubMed:30324136). Secreted toplasm Note=Secreted by macrophages and circulates in the blood (PubMed:20519120). Transported in the cytoplasm via CD36-mediated endocytosis (PubMed:20519120). Specifically expressed in tissue macrophages (PubMed:9892623). Expressed in thymus, liver, spleen and lymph nodes (PubMed:10651944). Present in Th17 cells; mainly present in non- pathogenic Th17 cells (PubMed:26607793). Transcription is activated by nuclear receptor liver X /retinoid X (RXR/LXR). N-glycosylated (PubMed:10651944, PubMed:23236605). N-glycan at Asn-99 possesses only alpha2,6-sialylated terminals, while Asn-229 possesses both alpha2,6-sialylated and non-sialylated terminals (PubMed:23236605). N-glycosylation increases secretion. Mice are apparently healthy under specific pathogen-free conditions. However, thymus of mice display much fewer thymocytes and CD4/CD8 double-positive (DP) thymocytes are more susceptible to apoptosis (PubMed:9892623). Increased adipocyte size and adipose tissue mass (PubMed:20519120). Higher level of free cholesterol in Th17 cells (PubMed:26607793). immune system process serine-type endopeptidase activity scavenger receptor activity extracellular region cytoplasm plasma membrane endocytosis apoptotic process inflammatory response cell surface membrane regulation of complement activation zymogen activation positive regulation of complement-dependent cytotoxicity uc008psa.1 uc008psa.2 uc008psa.3 uc008psa.4 
ENSMUST00000016023.9 Fam184b ENSMUST00000016023.9 family with sequence similarity 184, member B (from RefSeq NM_021416.3) ENSMUST00000016023.1 ENSMUST00000016023.2 ENSMUST00000016023.3 ENSMUST00000016023.4 ENSMUST00000016023.5 ENSMUST00000016023.6 ENSMUST00000016023.7 ENSMUST00000016023.8 F184B_MOUSE Kiaa1276 MNCb-2622 NM_021416 Q0KK51 Q0KK56 Q76KB4 Q7TNB6 Q9JJG2 uc008xja.1 uc008xja.2 uc008xja.3 uc008xja.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0KK56-1; Sequence=Displayed; Name=2; IsoId=Q0KK56-2; Sequence=VSP_031654, VSP_031655; Belongs to the FAM184 family. molecular_function cellular_component biological_process uc008xja.1 uc008xja.2 uc008xja.3 uc008xja.4 
ENSMUST00000016033.9 Lta4h ENSMUST00000016033.9 leukotriene A4 hydrolase, transcript variant 1 (from RefSeq NM_008517.2) ENSMUST00000016033.1 ENSMUST00000016033.2 ENSMUST00000016033.3 ENSMUST00000016033.4 ENSMUST00000016033.5 ENSMUST00000016033.6 ENSMUST00000016033.7 ENSMUST00000016033.8 LKHA4_MOUSE NM_008517 P24527 Q3UY71 Q8VDR8 uc007gur.1 uc007gur.2 uc007gur.3 The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities (By similarity). Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro- inflammatory mediator leukotriene B4 (LTB4) (PubMed:1881903, PubMed:9287304). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (By similarity). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (By similarity). Reaction=H2O + leukotriene A4 = leukotriene B4; Xref=Rhea:RHEA:22324, ChEBI:CHEBI:15377, ChEBI:CHEBI:57461, ChEBI:CHEBI:57463; EC=3.3.2.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22325; Evidence=; Reaction=(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate + H2O = resolvin E1; Xref=Rhea:RHEA:50272, ChEBI:CHEBI:15377, ChEBI:CHEBI:91000, ChEBI:CHEBI:132219; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50273; Evidence=; Reaction=(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate + H2O = 18S-resolvin E1; Xref=Rhea:RHEA:51988, ChEBI:CHEBI:15377, ChEBI:CHEBI:134661, ChEBI:CHEBI:136057; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51989; Evidence=; Reaction=Release of the N-terminal residue from a tripeptide.; EC=3.4.11.4; Evidence= Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Inhibited by bestatin (By similarity). The epoxide hydrolase activity is restrained by suicide inactivation that involves binding of LTA4 to Tyr-379 (PubMed:9287304). 4-(4-benzylphenyl)thiazol- 2-amine (ARM1) selectively inhibits the epoxide hydrolase activity (By similarity). Kinetic parameters: KM=5 uM for leukotriene A4 ; KM=1.59 uM for Pro-Gly-Pro ; Vmax=1030 nmol/min/mg enzyme for leukotriene A4 ; Lipid metabolism; leukotriene B4 biosynthesis. Monomer. Cytoplasm Phosphorylation at Ser-416 inhibits leukotriene-A4 hydrolase activity. Deficient mice have normal phenotypes. Inflammatory reactions are reduced as are some other immunological responses. Belongs to the peptidase M1 family. aminopeptidase activity epoxide hydrolase activity leukotriene-A4 hydrolase activity protein binding nucleus nucleoplasm cytoplasm cytosol proteolysis leukotriene metabolic process peptidase activity metallopeptidase activity zinc ion binding hydrolase activity leukotriene biosynthetic process peptide catabolic process cellular lipid metabolic process cellular protein metabolic process metal ion binding metalloaminopeptidase activity uc007gur.1 uc007gur.2 uc007gur.3 
ENSMUST00000016034.3 Amdhd1 ENSMUST00000016034.3 amidohydrolase domain containing 1 (from RefSeq NM_027908.1) ENSMUST00000016034.1 ENSMUST00000016034.2 HUTI_MOUSE NM_027908 Q7TPP5 Q811K3 Q8R230 Q9DBA8 uc007gut.1 uc007gut.2 uc007gut.3 Reaction=4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate; Xref=Rhea:RHEA:23660, ChEBI:CHEBI:15377, ChEBI:CHEBI:58928, ChEBI:CHEBI:77893; EC=3.5.2.7; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Name=Fe(3+); Xref=ChEBI:CHEBI:29034; Evidence=; Note=Binds 1 zinc or iron ion per subunit. ; Amino-acid degradation; L-histidine degradation into L- glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. Belongs to the metallo-dependent hydrolases superfamily. HutI family. cytoplasm histidine metabolic process histidine catabolic process hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides histidine catabolic process to glutamate and formamide histidine catabolic process to glutamate and formate metal ion binding imidazolonepropionase activity uc007gut.1 uc007gut.2 uc007gut.3 
ENSMUST00000016086.10 Gtf2ird2 ENSMUST00000016086.10 GTF2I repeat domain containing 2, transcript variant 1 (from RefSeq NM_053266.1) ENSMUST00000016086.1 ENSMUST00000016086.2 ENSMUST00000016086.3 ENSMUST00000016086.4 ENSMUST00000016086.5 ENSMUST00000016086.6 ENSMUST00000016086.7 ENSMUST00000016086.8 ENSMUST00000016086.9 GT2D2_MOUSE NM_053266 Q99NI3 uc008zve.1 uc008zve.2 uc008zve.3 Nucleus. Ubiquitous. No expression in embryo at 9.5 dpc and 10.5 dpc. Expressed in tooth epithelium at 13.5 dpc. At the early bell stage, Expression in preameloblasts and preodontoblasts. Belongs to the TFII-I family. DNA binding protein binding nucleus transition between fast and slow fiber uc008zve.1 uc008zve.2 uc008zve.3 
ENSMUST00000016088.9 Castor2 ENSMUST00000016088.9 cytosolic arginine sensor for mTORC1 subunit 2 (from RefSeq NM_030719.3) CAST2_MOUSE Castor2 ENSMUST00000016088.1 ENSMUST00000016088.2 ENSMUST00000016088.3 ENSMUST00000016088.4 ENSMUST00000016088.5 ENSMUST00000016088.6 ENSMUST00000016088.7 ENSMUST00000016088.8 Gats Gatsl2 NM_030719 Q8C7A9 Q8CAB8 Q9ER44 uc008zva.1 uc008zva.2 uc008zva.3 uc008zva.4 Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2- containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. Forms homodimers and heterodimers with CASTOR1. Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is not regulated by arginine. Cytoplasm, cytosol Belongs to the GATS family. cytoplasm cytosol identical protein binding regulation of intracellular signal transduction cellular response to L-arginine negative regulation of TORC1 signaling GATOR2 complex uc008zva.1 uc008zva.2 uc008zva.3 uc008zva.4 
ENSMUST00000016105.9 Adss2 ENSMUST00000016105.9 adenylosuccinate synthase 2, transcript variant 4 (from RefSeq NR_185123.1) Adss ENSMUST00000016105.1 ENSMUST00000016105.2 ENSMUST00000016105.3 ENSMUST00000016105.4 ENSMUST00000016105.5 ENSMUST00000016105.6 ENSMUST00000016105.7 ENSMUST00000016105.8 NR_185123 P46664 PURA2_MOUSE Q9CQL9 uc007dut.1 uc007dut.2 uc007dut.3 Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Reaction=GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2- dicarboxyethyl)-AMP + phosphate; Xref=Rhea:RHEA:15753, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:57567, ChEBI:CHEBI:58053, ChEBI:CHEBI:58189; EC=6.3.4.4; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Inhibited competitively by AMP and IMP and non- competitively by fructose 1,6-bisphosphate. Kinetic parameters: KM=15 uM for GTP ; KM=12 uM for IMP ; KM=950 uM for L-aspartate ; pH dependence: Optimum pH is 6.6-6.9. ; Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Homodimer. Cytoplasm Mitochondrion Belongs to the adenylosuccinate synthetase family. nucleotide binding magnesium ion binding adenylosuccinate synthase activity GTP binding cytoplasm cytosol plasma membrane purine nucleotide biosynthetic process AMP biosynthetic process aspartate metabolic process response to purine-containing compound ligase activity 'de novo' AMP biosynthetic process IMP metabolic process metal ion binding response to ammonium ion cellular response to electrical stimulus uc007dut.1 uc007dut.2 uc007dut.3 
ENSMUST00000016106.6 Spmip3 ENSMUST00000016106.6 sperm microtubule inner protein 3 (from RefSeq NM_027077.2) ENSMUST00000016106.1 ENSMUST00000016106.2 ENSMUST00000016106.3 ENSMUST00000016106.4 ENSMUST00000016106.5 NM_027077 Q9DAA7 SMIP3_MOUSE SPMIP3 uc007dur.1 uc007dur.2 uc007dur.3 molecular_function cellular_component biological_process uc007dur.1 uc007dur.2 uc007dur.3 
ENSMUST00000016110.13 Il17rb ENSMUST00000016110.13 interleukin 17 receptor B (from RefSeq NM_019583.3) ENSMUST00000016110.1 ENSMUST00000016110.10 ENSMUST00000016110.11 ENSMUST00000016110.12 ENSMUST00000016110.2 ENSMUST00000016110.3 ENSMUST00000016110.4 ENSMUST00000016110.5 ENSMUST00000016110.6 ENSMUST00000016110.7 ENSMUST00000016110.8 ENSMUST00000016110.9 Evi27 I17RB_MOUSE Il17br NM_019583 Q9JIP2 Q9JIP3 uc007sun.1 uc007sun.2 Receptor for the pro-inflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. Interacts with DAZAP2. Interacts with TRAF3IP2. [Isoform 1]: Cell membrane; Single-pass type I membrane protein. [Isoform 2]: Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JIP3-1; Sequence=Displayed; Name=2; IsoId=Q9JIP3-2; Sequence=VSP_001742, VSP_001743; Liver and testis. Expressed at lower level in kidney and lung. Expressed in selected T-cell, B-cell and myeloid cell lines. Evi27 is a common site of retroviral integration in Bxh2 murine myeloid leukemias, localized near the Il17rb gene. Proviral integrations result in increased expression of Il17rb on the cell surface. cytokine receptor activity extracellular region cytoplasm plasma membrane integral component of plasma membrane cell surface membrane integral component of membrane cytokine-mediated signaling pathway interleukin-17 receptor activity positive regulation of inflammatory response positive regulation of interleukin-5 secretion positive regulation of interleukin-13 secretion uc007sun.1 uc007sun.2 
ENSMUST00000016124.15 Lrrc27 ENSMUST00000016124.15 leucine rich repeat containing 27, transcript variant 1 (from RefSeq NM_027164.1) ENSMUST00000016124.1 ENSMUST00000016124.10 ENSMUST00000016124.11 ENSMUST00000016124.12 ENSMUST00000016124.13 ENSMUST00000016124.14 ENSMUST00000016124.2 ENSMUST00000016124.3 ENSMUST00000016124.4 ENSMUST00000016124.5 ENSMUST00000016124.6 ENSMUST00000016124.7 ENSMUST00000016124.8 ENSMUST00000016124.9 LRC27_MOUSE NM_027164 Q80YS5 Q9D6Z2 uc009kfm.1 uc009kfm.2 uc009kfm.3 Sequence=BAB26510.1; Type=Erroneous initiation; Evidence=; Sequence=BAE38281.1; Type=Erroneous initiation; Evidence=; molecular_function uc009kfm.1 uc009kfm.2 uc009kfm.3 
ENSMUST00000016125.12 Stk32c ENSMUST00000016125.12 serine/threonine kinase 32C, transcript variant 1 (from RefSeq NM_021302.4) ENSMUST00000016125.1 ENSMUST00000016125.10 ENSMUST00000016125.11 ENSMUST00000016125.2 ENSMUST00000016125.3 ENSMUST00000016125.4 ENSMUST00000016125.5 ENSMUST00000016125.6 ENSMUST00000016125.7 ENSMUST00000016125.8 ENSMUST00000016125.9 MNCb-1563 NM_021302 Pkek Q8QZV4 Q9JJG4 ST32C_MOUSE Stk32c uc009kfl.1 uc009kfl.2 uc009kfl.3 uc009kfl.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction metal ion binding uc009kfl.1 uc009kfl.2 uc009kfl.3 uc009kfl.4 
ENSMUST00000016138.11 Fnta ENSMUST00000016138.11 farnesyltransferase, CAAX box, alpha (from RefSeq NM_008033.4) ENSMUST00000016138.1 ENSMUST00000016138.10 ENSMUST00000016138.2 ENSMUST00000016138.3 ENSMUST00000016138.4 ENSMUST00000016138.5 ENSMUST00000016138.6 ENSMUST00000016138.7 ENSMUST00000016138.8 ENSMUST00000016138.9 FNTA_MOUSE NM_008033 Q61239 Q921F7 uc009lhi.1 uc009lhi.2 uc009lhi.3 Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic- aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. Reaction=(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:13345, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11535, ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:86019, ChEBI:CHEBI:175763; EC=2.5.1.58; Evidence=; Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537, ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533, ChEBI:CHEBI:86021; EC=2.5.1.59; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by the AGRIN-induced phosphorylation which is mediated by MUSK. Heterodimer of FNTA and FNTB (farnesyltransferase) (By similarity). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase) (By similarity). Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA. Belongs to the protein prenyltransferase subunit alpha family. prenyltransferase activity protein farnesyltransferase activity protein geranylgeranyltransferase activity CAAX-protein geranylgeranyltransferase activity Rab geranylgeranyltransferase activity cytoplasm microtubule associated complex CAAX-protein geranylgeranyltransferase complex protein farnesyltransferase complex microtubule binding positive regulation of cell proliferation protein prenyltransferase activity response to inorganic substance response to organic cyclic compound transferase activity protein prenylation protein farnesylation protein geranylgeranylation acetylcholine receptor regulator activity receptor tyrosine kinase binding response to cytokine alpha-tubulin binding negative regulation of apoptotic process neurotransmitter receptor metabolic process positive regulation of cell cycle positive regulation of nitric-oxide synthase biosynthetic process negative regulation of nitric-oxide synthase biosynthetic process positive regulation of tubulin deacetylation positive regulation of deacetylase activity regulation of neurotransmitter receptor activity drug binding zinc ion binding isoprenoid binding peptide binding uc009lhi.1 uc009lhi.2 uc009lhi.3 
ENSMUST00000016143.9 Wasf3 ENSMUST00000016143.9 WASP family, member 3, transcript variant 6 (from RefSeq NR_184697.1) ENSMUST00000016143.1 ENSMUST00000016143.2 ENSMUST00000016143.3 ENSMUST00000016143.4 ENSMUST00000016143.5 ENSMUST00000016143.6 ENSMUST00000016143.7 ENSMUST00000016143.8 NR_184697 Q8VHI6 WASF3_MOUSE Wave3 uc009anf.1 uc009anf.2 uc009anf.3 Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). Binds actin and the Arp2/3 complex. Cytoplasm, cytoskeleton Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain. Phosphorylation by ABL1 promotes lamellipodia formation and cell migration. Belongs to the SCAR/WAVE family. molecular_function actin binding cytoplasm cytoskeleton cytoskeleton organization regulation of cell shape oligodendrocyte development lamellipodium lamellipodium assembly actin cytoskeleton organization positive regulation of myelination postsynapse modification of postsynaptic actin cytoskeleton glutamatergic synapse uc009anf.1 uc009anf.2 uc009anf.3 
ENSMUST00000016168.9 Lbp ENSMUST00000016168.9 lipopolysaccharide binding protein (from RefSeq NM_008489.2) A2AC66 ENSMUST00000016168.1 ENSMUST00000016168.2 ENSMUST00000016168.3 ENSMUST00000016168.4 ENSMUST00000016168.5 ENSMUST00000016168.6 ENSMUST00000016168.7 ENSMUST00000016168.8 LBP_MOUSE NM_008489 Q61805 Q99KA0 uc008nqa.1 uc008nqa.2 Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:9144073). Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:24380872). When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14. Secreted Cytoplasmic granule membrane Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. lipopolysaccharide binding leukocyte chemotaxis involved in inflammatory response macrophage activation involved in immune response immune system process receptor binding extracellular region extracellular space lipid transport acute-phase response opsonization lipid binding cell surface lipopolysaccharide transport membrane lipopolysaccharide-mediated signaling pathway detection of molecule of bacterial origin response to lipopolysaccharide negative regulation of tumor necrosis factor production positive regulation of chemokine production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production macromolecule localization positive regulation of toll-like receptor 4 signaling pathway positive regulation of tumor necrosis factor biosynthetic process defense response to bacterium positive regulation of macrophage activation innate immune response positive regulation of cytolysis defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive regulation of phagocytosis, engulfment positive regulation of respiratory burst involved in inflammatory response lipoteichoic acid binding cellular response to lipopolysaccharide cellular response to lipoteichoic acid lipopeptide binding positive regulation of neutrophil chemotaxis regulation of membrane permeability uc008nqa.1 uc008nqa.2 
ENSMUST00000016172.10 Celsr1 ENSMUST00000016172.10 cadherin, EGF LAG seven-pass G-type receptor 1 (from RefSeq NM_009886.2) CELR1_MOUSE E9QK27 ENSMUST00000016172.1 ENSMUST00000016172.2 ENSMUST00000016172.3 ENSMUST00000016172.4 ENSMUST00000016172.5 ENSMUST00000016172.6 ENSMUST00000016172.7 ENSMUST00000016172.8 ENSMUST00000016172.9 NM_009886 O35161 uc007xdt.1 uc007xdt.2 uc007xdt.3 Receptor that may have an important role in cell/cell signaling during nervous system formation. O35161; Q7T0S3: atp6ap2.S; Xeno; NbExp=2; IntAct=EBI-8294650, EBI-8294706; Cell membrane; Multi-pass membrane protein. Expressed in the brain, where it is localized principally in the ependymal cell layer, choroid plexus and the area postrema. Also found in spinal cord and in the eye. First detected at 6 dpc. Predominantly expressed in the developing CNS, the emerging dorsal root ganglia and cranial ganglia. In the CNS, expression is uniform along the rostrocaudal axis. During gastrulation, it is expressed in the vicinity of the primitive streak, and becomes predominant in that area at late gastrulation. At 10 dpc, detected in ventricular zones (VZ), but not in marginal zones (MZ), and weakly in other structures. Between 12 dpc and 15 dpc, a high expression is present in the VZ in all brain areas. No expression in differentiated neuronal fields. In the newborn and postnatal stages, expression remains restricted to the VZ. Also found weakly in fetal lungs, kidney and epithelia. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. gastrulation with mouth forming second establishment of planar polarity neuron migration neural tube closure hair follicle development transmembrane signaling receptor activity G-protein coupled receptor activity calcium ion binding protein binding nucleoplasm plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway Rho protein signal transduction cell-cell signaling multicellular organism development central nervous system development locomotory behavior anterior/posterior pattern specification membrane integral component of membrane regulation of actin cytoskeleton organization wound healing establishment of planar polarity of embryonic epithelium inner ear morphogenesis apical protein localization regulation of neurotransmitter secretion protein dimerization activity establishment of body hair planar orientation orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis planar dichotomous subdivision of terminal units involved in lung branching morphogenesis lateral sprouting involved in lung morphogenesis planar cell polarity pathway involved in neural tube closure protein localization involved in establishment of planar polarity cell-cell adhesion uc007xdt.1 uc007xdt.2 uc007xdt.3 
ENSMUST00000016231.14 Fli1 ENSMUST00000016231.14 Friend leukemia integration 1, transcript variant 1 (from RefSeq NM_008026.6) ENSMUST00000016231.1 ENSMUST00000016231.10 ENSMUST00000016231.11 ENSMUST00000016231.12 ENSMUST00000016231.13 ENSMUST00000016231.2 ENSMUST00000016231.3 ENSMUST00000016231.4 ENSMUST00000016231.5 ENSMUST00000016231.6 ENSMUST00000016231.7 ENSMUST00000016231.8 ENSMUST00000016231.9 Fli1 NM_008026 Q544B3 Q544B3_MOUSE uc009orz.1 uc009orz.2 uc009orz.3 uc009orz.4 Nucleus Belongs to the ETS family. DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytosol regulation of transcription, DNA-templated nuclear body sequence-specific DNA binding positive regulation of transcription, DNA-templated uc009orz.1 uc009orz.2 uc009orz.3 uc009orz.4 
ENSMUST00000016279.11 N4bp2l1 ENSMUST00000016279.11 NEDD4 binding protein 2-like 1 (from RefSeq NM_133898.4) ENSMUST00000016279.1 ENSMUST00000016279.10 ENSMUST00000016279.2 ENSMUST00000016279.3 ENSMUST00000016279.4 ENSMUST00000016279.5 ENSMUST00000016279.6 ENSMUST00000016279.7 ENSMUST00000016279.8 ENSMUST00000016279.9 N42L1_MOUSE NM_133898 Q3UU88 Q3V2Q8 Q8BL78 Q8VE50 uc009auc.1 uc009auc.2 uc009auc.3 uc009auc.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3V2Q8-1; Sequence=Displayed; Name=2; IsoId=Q3V2Q8-2; Sequence=VSP_031320; Sequence=BAC32606.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc009auc.1 uc009auc.2 uc009auc.3 uc009auc.4 
ENSMUST00000016294.8 Tenm1 ENSMUST00000016294.8 teneurin transmembrane protein 1 (from RefSeq NM_011855.4) ENSMUST00000016294.1 ENSMUST00000016294.2 ENSMUST00000016294.3 ENSMUST00000016294.4 ENSMUST00000016294.5 ENSMUST00000016294.6 ENSMUST00000016294.7 NM_011855 Odz1 Q8CAT1 Q9WTS4 TEN1_MOUSE Tnm1 uc009tbc.1 uc009tbc.2 uc009tbc.3 uc009tbc.4 Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). [Teneurin C-terminal-associated peptide]: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking. [Ten-1 intracellular domain]: Induces gene transcription activation. Homodimer; disulfide-linked. Heterodimer with either TENM2 or TENM3. May also form heterodimer with TENM4. Ten-1 ICD interacts with SORBS1 (via third SH3 domain). Interacts with MBD1 isoform 2 (PubMed:15777793). Ten-1 ICD interacts with HINT1 (PubMed:31088288). [Isoform 1]: Cell membrane ; Single-pass membrane protein Note=Colocalizes with isoform 2 at the plasma membrane. [Isoform 2]: Cytoplasm. Cell membrane. Secreted Note=Transported to the cell membrane and probably secreted to function as an autocrine or paracrine signaling molecule. The lack of a hydrophobic segment sequence suggests that isoform 2 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. [Ten-1 intracellular domain]: Nucleus Nucleus speckle Nucleus matrix Cytoplasm, cytoskeleton [Teneurin C-terminal-associated peptide]: Nucleus Cytoplasm. Cell membrane. Note=Colocalizes with isoform 1 at the plasma membrane. Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WTS4-1; Sequence=Displayed; Name=2; Synonyms=TCAP-1; IsoId=Q9WTS4-2; Sequence=VSP_045018; Isoform 1 and isoform 2 are expressed in the brain. Isoform 2 is expressed in the granular layer of the dentate gyrus and the pyramidal layer (Py) of the CA1, CA2 and CA3 of the hippocampus (at protein level). Expressed in the cortex, thalamus, CA1, CA2, CA3, dentate gyrus and granular layer of the hippocampus. Weakly expressed in kidney, testis and lung. Isoform 1 and isoform 2 are expressed in hippocampal cells at 14 dpc (at protein level). EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds. Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins. [Isoform 2]: Once secreted, may also be cleaved to give rise to the TCAP-1 form. [Teneurin C-terminal-associated peptide]: Derives from the plasma membrane form by proteolytic processing. Further proteolytic cleavage may generate 11.9 and 4.7 kDa bioactive peptides. [Teneurin C-terminal-associated peptide]: Binds to the plasma membrane and may be internalized by a receptor- and caveolae- mediated endocytosis manner to reach cytosolic compartments in a dynamin-dependent manner. Belongs to the tenascin family. Teneurin subfamily. extracellular region nucleus cytoplasm endoplasmic reticulum Golgi apparatus cytoskeleton plasma membrane integral component of plasma membrane regulation of transcription from RNA polymerase III promoter heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules signal transduction neuropeptide signaling pathway membrane integral component of membrane nuclear matrix nuclear speck positive regulation of actin filament polymerization positive regulation of peptidyl-serine phosphorylation protein homodimerization activity neuron projection positive regulation of MAP kinase activity protein heterodimerization activity perinuclear region of cytoplasm neuron development cell adhesion molecule binding positive regulation of filopodium assembly positive regulation of intracellular protein transport uc009tbc.1 uc009tbc.2 uc009tbc.3 uc009tbc.4 
ENSMUST00000016309.16 Tmbim1 ENSMUST00000016309.16 transmembrane BAX inhibitor motif containing 1 (from RefSeq NM_027154.5) ENSMUST00000016309.1 ENSMUST00000016309.10 ENSMUST00000016309.11 ENSMUST00000016309.12 ENSMUST00000016309.13 ENSMUST00000016309.14 ENSMUST00000016309.15 ENSMUST00000016309.2 ENSMUST00000016309.3 ENSMUST00000016309.4 ENSMUST00000016309.5 ENSMUST00000016309.6 ENSMUST00000016309.7 ENSMUST00000016309.8 ENSMUST00000016309.9 NM_027154 Q3U717 Q3U717_MOUSE Tmbim1 uc007blv.1 uc007blv.2 uc007blv.3 uc007blv.4 Membrane ; Multi- pass membrane protein Belongs to the BI1 family. death receptor binding lysosomal membrane Golgi apparatus endosome membrane membrane integral component of membrane intracellular membrane-bounded organelle negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of Fas signaling pathway negative regulation of protein localization to plasma membrane uc007blv.1 uc007blv.2 uc007blv.3 uc007blv.4 
ENSMUST00000016323.11 Camk1g ENSMUST00000016323.11 calcium/calmodulin-dependent protein kinase I gamma, transcript variant 2 (from RefSeq NM_144817.3) ENSMUST00000016323.1 ENSMUST00000016323.10 ENSMUST00000016323.2 ENSMUST00000016323.3 ENSMUST00000016323.4 ENSMUST00000016323.5 ENSMUST00000016323.6 ENSMUST00000016323.7 ENSMUST00000016323.8 ENSMUST00000016323.9 KCC1G_MOUSE NM_144817 Q91VB2 uc007eel.1 uc007eel.2 uc007eel.3 Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17; Evidence=; Activated by Ca(2+)/calmodulin. Binding of calmodulin is thought to result in a conformational change and leads to activation through phosphorylation by CAMKK1. Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein Cell membrane ; Peripheral membrane protein Highly expressed in brain, in neuronal cell bodies of the central nucleus of amygdala and ventromedial hypothalamic nucleus. Also detected in heart, testis, and kidney. Expression starts at 11 dpc in parallel with the onset of development of the central nervous system. The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate. May be prenylated on Cys-474. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Golgi membrane nucleotide binding catalytic activity protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity calmodulin binding ATP binding cytoplasm Golgi apparatus plasma membrane calcium- and calmodulin-dependent protein kinase complex protein phosphorylation metabolic process endomembrane system membrane kinase activity phosphorylation transferase activity neuron projection uc007eel.1 uc007eel.2 uc007eel.3 
ENSMUST00000016383.10 Lonrf3 ENSMUST00000016383.10 LON peptidase N-terminal domain and ring finger 3 (from RefSeq NM_028894.1) ENSMUST00000016383.1 ENSMUST00000016383.2 ENSMUST00000016383.3 ENSMUST00000016383.4 ENSMUST00000016383.5 ENSMUST00000016383.6 ENSMUST00000016383.7 ENSMUST00000016383.8 ENSMUST00000016383.9 LONF3_MOUSE NM_028894 Q9D4H7 Rnf127 uc009sxn.1 uc009sxn.2 uc009sxn.3 metal ion binding uc009sxn.1 uc009sxn.2 uc009sxn.3 
ENSMUST00000016396.8 Atp5f1e ENSMUST00000016396.8 ATP synthase F1 subunit epsilon (from RefSeq NM_025983.3) Atp5e Atp5f1e ENSMUST00000016396.1 ENSMUST00000016396.2 ENSMUST00000016396.3 ENSMUST00000016396.4 ENSMUST00000016396.5 ENSMUST00000016396.6 ENSMUST00000016396.7 NM_025983 Q545F5 Q545F5_MOUSE uc008off.1 uc008off.2 uc008off.3 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Belongs to the eukaryotic ATPase epsilon family. mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) mitochondrial proton-transporting ATP synthase complex ATP synthesis coupled proton transport ATPase activity proton-transporting ATP synthase activity, rotational mechanism uc008off.1 uc008off.2 uc008off.3 
ENSMUST00000016399.6 Tubb1 ENSMUST00000016399.6 tubulin, beta 1 class VI (from RefSeq NM_001080971.2) A2AQ07 ENSMUST00000016399.1 ENSMUST00000016399.2 ENSMUST00000016399.3 ENSMUST00000016399.4 ENSMUST00000016399.5 NM_001080971 TBB1_MOUSE uc008ofe.1 uc008ofe.2 uc008ofe.3 uc008ofe.4 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with RANBP10. Cytoplasm, cytoskeleton The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation. Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility (PubMed:33414192). Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:15890843). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (PubMed:23897886). Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle GTPase activity structural constituent of cytoskeleton GTP binding cytoplasm cytoskeleton microtubule microtubule-based process spindle assembly uc008ofe.1 uc008ofe.2 uc008ofe.3 uc008ofe.4 
ENSMUST00000016400.9 Ctsz ENSMUST00000016400.9 cathepsin Z (from RefSeq NM_022325.5) CATZ_MOUSE ENSMUST00000016400.1 ENSMUST00000016400.2 ENSMUST00000016400.3 ENSMUST00000016400.4 ENSMUST00000016400.5 ENSMUST00000016400.6 ENSMUST00000016400.7 ENSMUST00000016400.8 NM_022325 Q9WUU7 uc008ofd.1 uc008ofd.2 uc008ofd.3 uc008ofd.4 This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate a mature enzyme with carboxypeptidase activity. An enzymatically inactive form of the protein, that is associated with the propeptide, may be involved in cancer cell invasion and proliferation. Homozygous knockout mice for this gene exhibit impaired cancer cell invasion in a breast cancer model. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008619.1, AK159618.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Capable of producing kinin potentiating peptides (By similarity). Reaction=Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.; EC=3.4.18.1; Evidence=; The disulfide bridge formed between Cys-35 in the propeptide and the active site residue Cys-94 may prevent activation of the zymogen through formation of a reversible covalent bond with the active site residue. Lysosome. Ubiquitous. Belongs to the peptidase C1 family. carboxypeptidase activity cysteine-type endopeptidase activity extracellular space lysosome endoplasmic reticulum proteolysis peptidase activity cysteine-type peptidase activity cell surface negative regulation of plasminogen activation negative regulation of neuron projection development hydrolase activity growth cone cytoplasmic vesicle negative regulation of protein binding intracellular membrane-bounded organelle positive regulation of neuron apoptotic process proteolysis involved in cellular protein catabolic process epithelial tube branching involved in lung morphogenesis cell cortex region regulation of neuron death positive regulation of neural precursor cell proliferation uc008ofd.1 uc008ofd.2 uc008ofd.3 uc008ofd.4 
ENSMUST00000016401.15 Prelid3b ENSMUST00000016401.15 PRELI domain containing 3B (from RefSeq NM_025531.2) A2ADM7 ENSMUST00000016401.1 ENSMUST00000016401.10 ENSMUST00000016401.11 ENSMUST00000016401.12 ENSMUST00000016401.13 ENSMUST00000016401.14 ENSMUST00000016401.2 ENSMUST00000016401.3 ENSMUST00000016401.4 ENSMUST00000016401.5 ENSMUST00000016401.6 ENSMUST00000016401.7 ENSMUST00000016401.8 ENSMUST00000016401.9 NM_025531 PLD3B_MOUSE Q3UC64 Q9CRD3 Q9CYY7 Slmo2 uc008ofg.1 uc008ofg.2 uc008ofg.3 Belongs to the slowmo family. mitochondrion mitochondrial intermembrane space phospholipid transport phosphatidic acid transporter activity uc008ofg.1 uc008ofg.2 uc008ofg.3 
ENSMUST00000016452.11 Ube2a ENSMUST00000016452.11 ubiquitin-conjugating enzyme E2A, transcript variant 1 (from RefSeq NM_019668.4) ENSMUST00000016452.1 ENSMUST00000016452.10 ENSMUST00000016452.2 ENSMUST00000016452.3 ENSMUST00000016452.4 ENSMUST00000016452.5 ENSMUST00000016452.6 ENSMUST00000016452.7 ENSMUST00000016452.8 ENSMUST00000016452.9 NM_019668 Q9Z255 Rad6a UBE2A_MOUSE uc009sxv.1 uc009sxv.2 uc009sxv.3 uc009sxv.4 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys- 120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence= Protein modification; protein ubiquitination. Interacts with RAD18 and WAC (By similarity). Interacts with RFPL4A and CCNB1 (PubMed:12525704). Phosphorylation at Ser-120 by CDK9 increases activity towards histone H2B. Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding protein polyubiquitination chromatin nuclear chromatin in utero embryonic development XY body blastocyst hatching ubiquitin-protein transferase activity protein binding ATP binding DNA repair cellular response to DNA damage stimulus positive regulation of cell proliferation response to UV protein ubiquitination transferase activity ubiquitin protein ligase binding HULC complex histone H2A ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process protein autoubiquitination maternal process involved in female pregnancy ubiquitin conjugating enzyme activity protein K48-linked ubiquitination protein K11-linked ubiquitination uc009sxv.1 uc009sxv.2 uc009sxv.3 uc009sxv.4 
ENSMUST00000016463.4 Slc25a5 ENSMUST00000016463.4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 (from RefSeq NM_007451.4) ENSMUST00000016463.1 ENSMUST00000016463.2 ENSMUST00000016463.3 NM_007451 Q545A2 Q545A2_MOUSE Slc25a5 uc009sxs.1 uc009sxs.2 uc009sxs.3 uc009sxs.4 This gene encodes a transmembrane domain-containing protein that localizes to the mitochondrial inner membrane. The encoded protein facilitates the exchange of ADP from the cytoplasm with ATP from the mitochondria. Pseudogenes for this gene are found on multiple chromosomes. [provided by RefSeq, May 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK012751.1, BC004570.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Catalyzes the exchange of ADP and ATP across the membrane. Reaction=ADP(in) + ATP(out) = ADP(out) + ATP(in); Xref=Rhea:RHEA:34999, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; Evidence=; Reaction=H(+)(in) = H(+)(out); Xref=Rhea:RHEA:34979, ChEBI:CHEBI:15378; Evidence=; Monomer. Membrane ulti-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. Lacks conserved residue(s) required for the propagation of feature annotation. mitochondrion mitochondrial inner membrane positive regulation of cell proliferation membrane integral component of membrane transmembrane transporter activity ubiquitin protein ligase binding mitochondrial nucleoid membrane raft transmembrane transport MMXD complex negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway uc009sxs.1 uc009sxs.2 uc009sxs.3 uc009sxs.4 
ENSMUST00000016488.13 Ppdpf ENSMUST00000016488.13 pancreatic progenitor cell differentiation and proliferation factor, transcript variant 1 (from RefSeq NM_025598.3) ENSMUST00000016488.1 ENSMUST00000016488.10 ENSMUST00000016488.11 ENSMUST00000016488.12 ENSMUST00000016488.2 ENSMUST00000016488.3 ENSMUST00000016488.4 ENSMUST00000016488.5 ENSMUST00000016488.6 ENSMUST00000016488.7 ENSMUST00000016488.8 ENSMUST00000016488.9 Exdpf NM_025598 PPDPF_MOUSE Q58EU5 Q9CR37 uc008oli.1 uc008oli.2 uc008oli.3 uc008oli.4 Probable regulator of exocrine pancreas development. Belongs to the PPDPF family. molecular_function cellular_component multicellular organism development cell differentiation uc008oli.1 uc008oli.2 uc008oli.3 uc008oli.4 
ENSMUST00000016498.5 Srms ENSMUST00000016498.5 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (from RefSeq NM_011481.3) ENSMUST00000016498.1 ENSMUST00000016498.2 ENSMUST00000016498.3 ENSMUST00000016498.4 NM_011481 Q0VBH4 Q0VBH4_MOUSE Srms uc008oll.1 uc008oll.2 uc008oll.3 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Belongs to the protein kinase superfamily. Tyr protein kinase family. nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity ATP binding cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation peptidyl-tyrosine autophosphorylation uc008oll.1 uc008oll.2 uc008oll.3 
ENSMUST00000016511.6 Ptk6 ENSMUST00000016511.6 PTK6 protein tyrosine kinase 6, transcript variant 1 (from RefSeq NM_009184.2) ENSMUST00000016511.1 ENSMUST00000016511.2 ENSMUST00000016511.3 ENSMUST00000016511.4 ENSMUST00000016511.5 NM_009184 PTK6_MOUSE Q64434 Sik uc008olk.1 uc008olk.2 uc008olk.3 Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non- tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Activated by EGF, NRG1 and IGF1. Inhibited by SOCS3 to phosphorylate STAT3. Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region. Interaction between Trp-184 within SH2-TK linker region and the catalytic domain appears essential for positive regulation of kinase activity. Interacts with KHDRBS1. Interacts with phosphorylated IRS4 (By similarity). Interacts with GAP-A.p65. Interacts with ADAM15 (By similarity). Interacts (via SH3 and SH2 domains) with phosphorylated IRS4 (By similarity). Interacts (via SH3 domain) with SFPQ (By similarity). Interacts with EGFR and ERBB2 (By similarity). Interacts with STAP2 (By similarity). Interacts with PNX (By similarity). Interacts with SFPQ (By similarity). Interacts with PTK/ATK (By similarity). Interacts with CTNNB1 (By similarity). Cytoplasm. Nucleus. Membrane. Cell projection, ruffle Note=Also found to be membrane-associated. Colocalizes with KHDRBS1, within the nucleus. Expressed only in epithelial tissues, including the skin and lining of the alimentary canal. Restricted to the cell layers immediately above the proliferative cell zone in these epithelia. First detected at day 15.5 of gestation in the embryo, where it is expressed in the newly forming granular layer of the skin. Is found in stomach at day 17.5. The SH3 domain plays a major role in substrate interactions. The SH2 domain of PTK6 plays a role in protein-protein interactions, but is likely more important for the regulation of catalytic activity (By similarity). Autophosphorylated. Autophosphorylation of Tyr-342 leads to an increase of kinase activity. Tyr-447 binds to the SH2 domain when phosphorylated and negatively regulates kinase activity (By similarity). Deficient mice have an increased cell turnover in the small intestine, which is accompanied by increased villus length and crypt depth and delayed enterocyte differentiation that is accompanied by increased PTK/AKT and WNT signaling. Belongs to the protein kinase superfamily. Tyr protein kinase family. BRK/PTK6/SIK subfamily. nucleotide binding ruffle protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding ATP binding nucleus nucleoplasm cytoplasm cytosol plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway tyrosine phosphorylation of STAT protein positive regulation of neuron projection development membrane kinase activity phosphorylation cell migration nuclear body transferase activity cell differentiation extrinsic component of cytoplasmic side of plasma membrane peptidyl-tyrosine autophosphorylation regulation of cell proliferation identical protein binding cell projection negative regulation of growth protein autophosphorylation intestinal epithelial cell differentiation negative regulation of protein tyrosine kinase activity cellular response to retinoic acid uc008olk.1 uc008olk.2 uc008olk.3 
ENSMUST00000016553.5 Nkap ENSMUST00000016553.5 NFKB activating protein (from RefSeq NM_025937.4) ENSMUST00000016553.1 ENSMUST00000016553.2 ENSMUST00000016553.3 ENSMUST00000016553.4 NKAP_MOUSE NM_025937 Q8BTK6 Q8BYT5 Q8R324 Q9CSH4 Q9D0F4 uc009syg.1 uc009syg.2 uc009syg.3 uc009syg.4 Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF- kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (By similarity). Component of the Notch corepressor complex. Interacts with CIR1 and HDAC3 (By similarity). Nucleus Belongs to the NKAP family. negative regulation of transcription from RNA polymerase II promoter chromatin binding nucleus nucleoplasm cytosol Notch signaling pathway stem cell population maintenance hemopoiesis granulocyte differentiation chromatin DNA binding T cell differentiation in thymus negative regulation of transcription, DNA-templated positive regulation of alpha-beta T cell differentiation hematopoietic stem cell proliferation uc009syg.1 uc009syg.2 uc009syg.3 uc009syg.4 
ENSMUST00000016571.8 Ndufa1 ENSMUST00000016571.8 NADH:ubiquinone oxidoreductase subunit A1 (from RefSeq NM_019443.2) ENSMUST00000016571.1 ENSMUST00000016571.2 ENSMUST00000016571.3 ENSMUST00000016571.4 ENSMUST00000016571.5 ENSMUST00000016571.6 ENSMUST00000016571.7 NM_019443 Ndufa1 Q545K0 Q545K0_MOUSE uc009syi.1 uc009syi.2 uc009syi.3 uc009syi.4 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side Belongs to the complex I NDUFA1 subunit family. mitochondrion mitochondrial respiratory chain complex I cytosol membrane integral component of membrane mitochondrial membrane mitochondrial respiratory chain complex I assembly uc009syi.1 uc009syi.2 uc009syi.3 uc009syi.4 
ENSMUST00000016631.14 Ppfibp1 ENSMUST00000016631.14 PTPRF interacting protein, binding protein 1 (liprin beta 1), transcript variant 2 (from RefSeq NM_026221.2) ENSMUST00000016631.1 ENSMUST00000016631.10 ENSMUST00000016631.11 ENSMUST00000016631.12 ENSMUST00000016631.13 ENSMUST00000016631.2 ENSMUST00000016631.3 ENSMUST00000016631.4 ENSMUST00000016631.5 ENSMUST00000016631.6 ENSMUST00000016631.7 ENSMUST00000016631.8 ENSMUST00000016631.9 Kiaa1230 LIPB1_MOUSE NM_026221 Q69ZN5 Q6GQV3 Q80VB4 Q8C8U0 Q9CUT7 uc009esm.1 uc009esm.2 uc009esm.3 uc009esm.4 May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity). Forms homodimers and heterodimers. Interacts with S100A4 in a calcium-dependent mode (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C8U0-1; Sequence=Displayed; Name=2; IsoId=Q8C8U0-2; Sequence=VSP_012095; Name=3; IsoId=Q8C8U0-3; Sequence=VSP_012096; The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4 (By similarity). Belongs to the liprin family. Liprin-beta subfamily. Sequence=BAD32411.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; uc009esm.1 uc009esm.2 uc009esm.3 uc009esm.4 
ENSMUST00000016638.8 Cd34 ENSMUST00000016638.8 CD34 antigen, transcript variant 2 (from RefSeq NM_133654.4) CD34_MOUSE ENSMUST00000016638.1 ENSMUST00000016638.2 ENSMUST00000016638.3 ENSMUST00000016638.4 ENSMUST00000016638.5 ENSMUST00000016638.6 ENSMUST00000016638.7 NM_133654 Q62550 Q62551 Q64314 uc007eeq.1 uc007eeq.2 uc007eeq.3 uc007eeq.4 Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). Membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q64314-1; Sequence=Displayed; Name=Short; IsoId=Q64314-2; Sequence=VSP_004161, VSP_004162; Expressed in the kidney where it is detected in the thin limb of Henle's loop (at protein level) (PubMed:31605441). Highly expressed in hematopoietic progenitor cell lines, brain and testis, and moderately in the thymus, spleen, and bone marrow, but not in adult liver (PubMed:1709048). Highly glycosylated. Phosphorylated on serine residues by PKC. Belongs to the CD34 family. tissue homeostasis endothelial cell proliferation glomerular filtration endothelium development extracellular region cytoplasm lysosome plasma membrane cell adhesion signal transduction transcription factor binding regulation of blood pressure cell proliferation external side of plasma membrane basal plasma membrane cell surface positive regulation of gene expression negative regulation of gene expression membrane integral component of membrane apical plasma membrane hemopoiesis negative regulation of blood coagulation carbohydrate binding negative regulation of tumor necrosis factor production positive regulation of interleukin-10 production mesangial cell-matrix adhesion glomerular endothelium fenestra paracrine signaling positive regulation of odontogenesis sulfate binding negative regulation of nitric oxide biosynthetic process intercellular bridge positive regulation of angiogenesis perinuclear region of cytoplasm cell motility leukocyte migration transdifferentiation vascular wound healing hematopoietic stem cell proliferation positive regulation of transforming growth factor beta production positive regulation of granulocyte colony-stimulating factor production cell periphery extracellular exosome assembly glomerular endothelium development stem cell proliferation metanephric glomerular mesangial cell differentiation cell-cell adhesion negative regulation of cellular response to heat negative regulation of cellular response to hypoxia negative regulation of interleukin-2 secretion positive regulation of glial cell-derived neurotrophic factor secretion negative regulation of neuron death positive regulation of vasculogenesis uc007eeq.1 uc007eeq.2 uc007eeq.3 uc007eeq.4 
ENSMUST00000016640.8 Cd274 ENSMUST00000016640.8 CD274 antigen (from RefSeq NM_021893.3) B7h1 ENSMUST00000016640.1 ENSMUST00000016640.2 ENSMUST00000016640.3 ENSMUST00000016640.4 ENSMUST00000016640.5 ENSMUST00000016640.6 ENSMUST00000016640.7 NM_021893 PD1L1_MOUSE Pdcd1l1 Pdcd1lg1 Pdl1 Q9EP73 uc008hdi.1 uc008hdi.2 uc008hdi.3 uc008hdi.4 uc008hdi.5 The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066841.1, AK154403.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11238124). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11238124). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:11015443, PubMed:12719480). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:12218188, PubMed:27281199). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:12218188). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T- cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:12218188). Interacts with PDCD1 (PubMed:11015443). Interacts with CMTM4 and CMTM6 (By similarity). Q9EP73; Q00609: Cd80; NbExp=7; IntAct=EBI-5258879, EBI-5258929; Q9EP73; Q02242: Pdcd1; NbExp=3; IntAct=EBI-5258879, EBI-5258903; Cell membrane ; Single-pass type I membrane protein Early endosome membrane ; Single-pass type I membrane protein Recycling endosome membrane ; Single-pass type I membrane protein Highly expressed in the heart, thymus, skeletal muscle, and lung. Weakly expressed in the kidney, spleen, thyroid, and liver. Expressed on activated dendritic cells, B-cells and macrophages. Expressed in numerous tumor cells lines of lymphoid origin. Up-regulated by IFNG treatment in monocytes. Up-regulated on dendritic cells, B-cells and macrophages after activation by LPS and IFNG. Ubiquitinated; STUB1 likely mediates polyubiquitination of PD- L1/CD274 triggering its degradation. Ubiquitinated by MARCHF8; leading to degradation. Belongs to the immunoglobulin superfamily. BTN/MOG family. adaptive immune response immune system process positive regulation of tolerance induction to tumor cell protein binding endosome plasma membrane immune response signal transduction cell surface receptor signaling pathway external side of plasma membrane cell surface membrane integral component of membrane positive regulation of cell migration T cell costimulation early endosome membrane negative regulation of interferon-gamma production negative regulation of interleukin-10 production response to cytokine positive regulation of T cell proliferation negative regulation of T cell proliferation negative regulation of activated T cell proliferation recycling endosome membrane extracellular exosome cellular response to lipopolysaccharide toxin transport negative regulation of tumor necrosis factor superfamily cytokine production positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of interleukin-10 secretion negative regulation of CD8-positive, alpha-beta T cell activation uc008hdi.1 uc008hdi.2 uc008hdi.3 uc008hdi.4 uc008hdi.5 
ENSMUST00000016664.8 Lnx2 ENSMUST00000016664.8 ligand of numb-protein X 2, transcript variant 4 (from RefSeq NR_188904.1) A6PW04 ENSMUST00000016664.1 ENSMUST00000016664.2 ENSMUST00000016664.3 ENSMUST00000016664.4 ENSMUST00000016664.5 ENSMUST00000016664.6 ENSMUST00000016664.7 LNX2_MOUSE NR_188904 Q8CBE1 Q91XL2 uc009ant.1 uc009ant.2 uc009ant.3 uc009ant.4 Interacts with the phosphotyrosine interaction domain of NUMB. Widely expressed. The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient. protein binding cellular_component PDZ domain binding identical protein binding metal ion binding uc009ant.1 uc009ant.2 uc009ant.3 uc009ant.4 
ENSMUST00000016670.9 Dyrk3 ENSMUST00000016670.9 dual-specificity tyrosine phosphorylation regulated kinase 3, transcript variant 1 (from RefSeq NM_145508.3) DYRK3_MOUSE Dyrk3 ENSMUST00000016670.1 ENSMUST00000016670.2 ENSMUST00000016670.3 ENSMUST00000016670.4 ENSMUST00000016670.5 ENSMUST00000016670.6 ENSMUST00000016670.7 ENSMUST00000016670.8 NM_145508 Q8BM34 Q922Y0 uc007cmw.1 uc007cmw.2 uc007cmw.3 Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (By similarity). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:12356771). Acts as a central dissolvase of membraneless organelles during the G2- to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (By similarity). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (By similarity). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (By similarity). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (By similarity). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (By similarity). Also acts as a negative regulator of EPO- dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (By similarity). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence= Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Protein kinase activity is activated following autophosphorylation at Tyr-368. Interacts with SIRT1. Q922Y0; Q923E4: Sirt1; NbExp=7; IntAct=EBI-5242007, EBI-1802585; Nucleus Cytoplasm Nucleus speckle Cytoplasmic granule Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Associates with membraneless organelles in the cytoplasm and nucleus. Shuttles between cytoplasm and stress granules. Localized predominantly on distinct speckles distributed throughout the cytoplasm of the cell. At low concentration, showns a homogeneous distribution throughout the cytoplasm and does not condense in speckles. During oxidative and osmotic stress, localizes to stress granules. The N-terminal domain, which is intrinsically disordered, is required for stress granule localization. Ubiquitinated at anaphase by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Protein kinase activity is activated following autophosphorylation at Tyr-368. Mice exhibit unperturbed steady-state erythropoiesis but significantly increased reticulocyte production during stress erythropoiesis and appear to be partially protected against anemia. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. nucleotide binding pericentriolar material magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm microtubule organizing center cytosol cytoskeleton protein phosphorylation cell cycle cytoplasmic stress granule kinase activity phosphorylation nuclear speck transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation erythrocyte differentiation nuclear speck organization stress granule disassembly negative regulation of apoptotic process intracellular membrane-bounded organelle negative regulation of DNA damage response, signal transduction by p53 class mediator metal ion binding cell division regulation of cellular response to stress positive regulation of cell cycle G2/M phase transition organelle disassembly regulation of TORC1 signaling uc007cmw.1 uc007cmw.2 uc007cmw.3 
ENSMUST00000016672.11 Mapkapk2 ENSMUST00000016672.11 MAP kinase-activated protein kinase 2 (from RefSeq NM_008551.2) ENSMUST00000016672.1 ENSMUST00000016672.10 ENSMUST00000016672.2 ENSMUST00000016672.3 ENSMUST00000016672.4 ENSMUST00000016672.5 ENSMUST00000016672.6 ENSMUST00000016672.7 ENSMUST00000016672.8 ENSMUST00000016672.9 Mapkapk2 NM_008551 Q3U2P8 Q3U2P8_MOUSE uc007cmv.1 uc007cmv.2 uc007cmv.3 uc007cmv.4 uc007cmv.5 Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleoplasm cytoplasm centrosome protein phosphorylation cellular response to DNA damage stimulus peptidyl-serine phosphorylation regulation of tumor necrosis factor production response to cytokine cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor signaling pathway 3'-UTR-mediated mRNA stabilization uc007cmv.1 uc007cmv.2 uc007cmv.3 uc007cmv.4 uc007cmv.5 
ENSMUST00000016673.6 Il10 ENSMUST00000016673.6 interleukin 10 (from RefSeq NM_010548.2) ENSMUST00000016673.1 ENSMUST00000016673.2 ENSMUST00000016673.3 ENSMUST00000016673.4 ENSMUST00000016673.5 IL10_MOUSE Il-10 NM_010548 P18893 Q0VBJ1 uc007cmu.1 uc007cmu.2 uc007cmu.3 uc007cmu.4 This gene encodes an anti-inflammatory cytokine that is a member of the class-2 cytokine family. The encoded protein is secreted by cells of both the innate and adaptive immune systems and is crucial for limiting the immune response to a broad range of pathogens. It also has been shown to suppress autoimmune responses. This protein mediates it's immunosuppressive signal through a specific interleukin 10 receptor complex. Aberrant functioning of this gene is associated with numerous immune disorders including graft-versus-host disease, and increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK152344.1, BC120612.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164133, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity) (PubMed:28473584). Homodimer. Interacts with IL10RA and IL10RB. Secreted Belongs to the IL-10 family. negative regulation of cytokine production positive regulation of endothelial cell proliferation response to molecule of bacterial origin negative regulation of cytokine secretion involved in immune response negative regulation of chronic inflammatory response to antigenic stimulus positive regulation of B cell apoptotic process cytokine activity interleukin-10 receptor binding extracellular region extracellular space inflammatory response immune response signal transduction aging negative regulation of cell proliferation response to organic substance regulation of gene expression negative regulation of autophagy response to activity response to inactivity negative regulation of myeloid dendritic cell activation negative regulation of B cell proliferation response to lipopolysaccharide negative regulation of interferon-gamma production negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production receptor biosynthetic process response to insulin negative regulation of heterotypic cell-cell adhesion response to carbon monoxide cellular response to hepatocyte growth factor stimulus response to drug negative regulation of tumor necrosis factor biosynthetic process defense response to bacterium defense response to protozoan positive regulation of macrophage activation negative regulation of apoptotic process negative regulation of nitric oxide biosynthetic process negative regulation of MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade protein dimerization activity positive regulation of cytokine secretion negative regulation of inflammatory response regulation of synapse organization negative regulation of membrane protein ectodomain proteolysis positive regulation of sequence-specific DNA binding transcription factor activity response to glucocorticoid regulation of sensory perception of pain negative regulation of cytokine activity branching involved in labyrinthine layer morphogenesis cellular response to lipopolysaccharide cellular response to estradiol stimulus liver regeneration positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of response to wounding negative regulation of hydrogen peroxide-induced neuron death positive regulation of sprouting angiogenesis negative regulation of sensory perception of pain negative regulation of vascular smooth muscle cell proliferation negative regulation of endothelial cell apoptotic process uc007cmu.1 uc007cmu.2 uc007cmu.3 uc007cmu.4 
ENSMUST00000016678.14 Lamp2 ENSMUST00000016678.14 lysosomal-associated membrane protein 2, transcript variant 4 (from RefSeq NR_152733.1) A2A430 ENSMUST00000016678.1 ENSMUST00000016678.10 ENSMUST00000016678.11 ENSMUST00000016678.12 ENSMUST00000016678.13 ENSMUST00000016678.2 ENSMUST00000016678.3 ENSMUST00000016678.4 ENSMUST00000016678.5 ENSMUST00000016678.6 ENSMUST00000016678.7 ENSMUST00000016678.8 ENSMUST00000016678.9 LAMP2_MOUSE Lamp-2 NR_152733 P17047 Q3TXG5 Q8BSG8 uc009szw.1 uc009szw.2 uc009szw.3 uc009szw.4 Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy (PubMed:10972293). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (By similarity). Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (By similarity). Functions by binding target proteins, such as GAPDH, NLRP3 and MLLT11, and targeting them for lysosomal degradation (By similarity). In the chaperone- mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2 (By similarity). Plays a role in lysosomal protein degradation in response to starvation (PubMed:27628032). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:10972293, PubMed:12221139). Required for efficient MHC class II-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHC II subunits (By similarity). Is not required for efficient MHC class II-mediated presentation of endogenous antigens (By similarity). Monomer. Forms large homooligomers (By similarity). Interacts (via its cytoplasmic region) with HSPA8; HSPA8 mediates recruitment of proteins with a KFERQ motif to the surface of the lysosome for chaperone-mediated autophagy (By similarity). Interacts with HSP90 in the lysosome lumen; this enhances LAMP2 stability (By similarity). Interacts with MLLT11 (By similarity). Interacts with ABCB9 (PubMed:22641697). Interacts with FURIN (By similarity). Interacts with CT55; this interaction may be important for LAMP2 protein stability (By similarity). Interacts with TMEM175; inhibiting the proton channel activity of TMEM175 (By similarity). Lysosome membrane ingle-pass type I membrane protein Endosome membrane ; Single-pass type I membrane protein Cytoplasmic vesicle, autophagosome membrane Cell membrane ; Single-pass type I membrane protein Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. Event=Alternative splicing; Named isoforms=3; Name=LAMP-2A; IsoId=P17047-1; Sequence=Displayed; Name=LAMP-2B; IsoId=P17047-2; Sequence=VSP_003045; Name=LAMP-2C; IsoId=P17047-3; Sequence=VSP_003046; Detected in liver and kidney (at protein level). Detected in liver and kidney. Extensively N-glycosylated. Contains a minor proportion of O- linked glycans. About half of the mutant mice die between 20 and 40 days after birth. Survivors are smaller, weigh 10 to 15 % less than their littermates, but show normal lifespan. Both mice that die early and long-time survivors display an accumulation of autophagic vacuoles in liver, pancreas, cardiac and skeletal muscle. Mutant mice display an increased ratio of heart weight to body weight and severely impaired contractile function of the heart muscle. Hepatocytes from mutant mice show a decreased rate of degradation of long-lived proteins. Belongs to the LAMP family. autophagosome membrane protein binding extracellular space lysosome lysosomal membrane endosome late endosome trans-Golgi network plasma membrane protein targeting autophagy cellular response to starvation endosome membrane membrane integral component of membrane enzyme binding protein domain specific binding phagocytic vesicle membrane platelet dense granule membrane cytoplasmic vesicle regulation of protein stability late endosome membrane negative regulation of protein homooligomerization autolysosome muscle cell cellular homeostasis perinuclear region of cytoplasm protein stabilization chaperone-mediated autophagy protein targeting to lysosome involved in chaperone-mediated autophagy chaperone-mediated autophagy translocation complex extracellular exosome establishment of protein localization to organelle autophagosome maturation integral component of autophagosome membrane lysosomal protein catabolic process lysosomal matrix membrane raft uc009szw.1 uc009szw.2 uc009szw.3 uc009szw.4 
ENSMUST00000016680.14 Cul4a ENSMUST00000016680.14 cullin 4A, transcript variant 1 (from RefSeq NM_146207.3) CUL4A_MOUSE Cul4a ENSMUST00000016680.1 ENSMUST00000016680.10 ENSMUST00000016680.11 ENSMUST00000016680.12 ENSMUST00000016680.13 ENSMUST00000016680.2 ENSMUST00000016680.3 ENSMUST00000016680.4 ENSMUST00000016680.5 ENSMUST00000016680.6 ENSMUST00000016680.7 ENSMUST00000016680.8 ENSMUST00000016680.9 NM_146207 Q3TCH7 Q3THM3 Q91Z44 uc009kww.1 uc009kww.2 uc009kww.3 uc009kww.4 uc009kww.5 Core component of multiple cullin-RING-based E3 ubiquitin- protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication- independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of p53/TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(DTL) directs autoubiquitination of DTL. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1. A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C- degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. With CUL4B, contributes to ribosome biogenesis. The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin- protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes. Protein modification; protein ubiquitination. Can self-associate. Component of multiple DCX (DDB1-CUL4-X- box) E3 ubiquitin-protein ligase complexes that seem to consist of DDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein family described as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40- repeat) proteins. Component of the CSA complex (DCX(ERCC8) complex) containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II. Component of the DCX(DET1-COP1) complex with the substrate recognition component DET1 and COP1. Component of the DCX(DDB2) complex with the substrate recognition component DDB2. Component of the DCX(DTL) complex with the putative substrate recognition component DTL. Component of DCX complexes part of the DesCEND (destruction via C-end degrons) pathway, which contain either TRPC4AP or DCAF12 as substrate-recognition component. Component of the DCX(AMBRA1) complex with the substrate recognition component AMBRA1. Interacts with DDB1, RBX1, RNF7, CDT1, TIP120A/CAND1, SKP2, CDKN1B, MDM2, TP53 and HOXA9. Interacts with DDB2; the interactions with DDB2 and CAND1 are mutually exclusive. Interacts with DCAF1, DTL, DDA1, DCAF6, DCAF4, DCAF16, DCAF17, DET1, WDTC1, DCAF5, DCAF11, WDR24A, COP1, PAFAH1B1, ERCC8, GRWD1, FBXW5, RBBP7, GNB2, WSB1, WSB2, NUP43, PWP1, FBXW8, ATG16L1, KATNB1, RBBP4, RBBP5, LRWD1 and DCAF8. May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76, WDR5. Interacts (when neddylated) with ARIH1; leading to activate the E3 ligase activity of ARIH1. The DDB1-CUL4A complex interacts with CRY1. Interacts (unneddylated form) with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5; these interactions promote the cullin neddylation. (Microbial infection) Interacts with murine cytomegalovirus M48. Expressed in oocytes (at protein level) (PubMed:24357321). In the ovary, also expressed in cumulus cells. Expressed in testis, spleen and kidney (PubMed:24357321). Expressed at high levels in germinal vesicle (GV) stage oocytes and at lower levels in MII-stage oocytes and zygotes. Expression then decreases from 4-cell stage to blastula. Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex. (Microbial infection) Deneddylated by murine cytomegalovirus M48 leading to a S-phase-like environment that is required for efficient replication of the viral genome. Belongs to the cullin family. in utero embryonic development protein binding DNA repair ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus positive regulation of cell proliferation viral process protein ubiquitination SCF ubiquitin ligase complex hemopoiesis negative regulation of granulocyte differentiation SCF-dependent proteasomal ubiquitin-dependent protein catabolic process cullin-RING ubiquitin ligase complex Cul4A-RING E3 ubiquitin ligase complex ubiquitin protein ligase binding somatic stem cell population maintenance ribosome biogenesis proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process rhythmic process regulation of protein metabolic process Cul4-RING E3 ubiquitin ligase complex positive regulation of G1/S transition of mitotic cell cycle regulation of DNA damage checkpoint regulation of nucleotide-excision repair uc009kww.1 uc009kww.2 uc009kww.3 uc009kww.4 uc009kww.5 
ENSMUST00000016681.15 Cul4b ENSMUST00000016681.15 Protein modification; protein ubiquitination. (from UniProt E9PXY1) AK012410 Cul4b E9PXY1 E9PXY1_MOUSE ENSMUST00000016681.1 ENSMUST00000016681.10 ENSMUST00000016681.11 ENSMUST00000016681.12 ENSMUST00000016681.13 ENSMUST00000016681.14 ENSMUST00000016681.2 ENSMUST00000016681.3 ENSMUST00000016681.4 ENSMUST00000016681.5 ENSMUST00000016681.6 ENSMUST00000016681.7 ENSMUST00000016681.8 ENSMUST00000016681.9 uc292nvl.1 uc292nvl.2 Protein modification; protein ubiquitination. Belongs to the cullin family. ubiquitin-dependent protein catabolic process cullin-RING ubiquitin ligase complex ubiquitin protein ligase binding uc292nvl.1 uc292nvl.2 
ENSMUST00000016696.13 Foxred2 ENSMUST00000016696.13 FAD-dependent oxidoreductase domain containing 2, transcript variant 2 (from RefSeq NM_001017983.3) D15Bwg0759e ENSMUST00000016696.1 ENSMUST00000016696.10 ENSMUST00000016696.11 ENSMUST00000016696.12 ENSMUST00000016696.2 ENSMUST00000016696.3 ENSMUST00000016696.4 ENSMUST00000016696.5 ENSMUST00000016696.6 ENSMUST00000016696.7 ENSMUST00000016696.8 ENSMUST00000016696.9 FXRD2_MOUSE Foxred2 NM_001017983 Q3TCC4 Q3USW5 Q5RJH0 uc007woj.1 uc007woj.2 uc007woj.3 Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation (By similarity). Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Interacts with SEL1L. May interact with OS9 and DNAJC10. Interacts with TXNDC16. Endoplasmic reticulum lumen N-glycosylated. Belongs to the FOXRED2 family. Sequence=BAE42033.1; Type=Frameshift; Evidence=; endoplasmic reticulum endoplasmic reticulum lumen oxidoreductase activity ER-associated ubiquitin-dependent protein catabolic process flavin adenine dinucleotide binding oxidation-reduction process uc007woj.1 uc007woj.2 uc007woj.3 
ENSMUST00000016771.13 Myh9 ENSMUST00000016771.13 myosin, heavy polypeptide 9, non-muscle (from RefSeq NM_022410.4) ENSMUST00000016771.1 ENSMUST00000016771.10 ENSMUST00000016771.11 ENSMUST00000016771.12 ENSMUST00000016771.2 ENSMUST00000016771.3 ENSMUST00000016771.4 ENSMUST00000016771.5 ENSMUST00000016771.6 ENSMUST00000016771.7 ENSMUST00000016771.8 ENSMUST00000016771.9 MYH9_MOUSE NM_022410 Q3UHT9 Q3UHU4 Q6KAN6 Q811I2 Q8VDD5 uc007woc.1 uc007woc.2 uc007woc.3 uc007woc.4 Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (PubMed:19401332). Required for cortical actin clearance prior to oocyte exocytosis (PubMed:31118423). Promotes cell motility in conjunction with S100A4 (By similarity). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1 (PubMed:21396893). Interacts with DDR1 (PubMed:19401332). Interacts with PDLIM2 (By similarity). Interacts with SVIL (By similarity). Interacts with HTRA3 (By similarity). Interacts with Myo7a (PubMed:27331610). Interacts with CFAP95 (By similarity). Interacts with LIMCH1; independently of the integration of MYH9 into the myosin complex (By similarity). Interacts with RAB3A (By similarity). Interacts with ZBED4 (By similarity). Interacts with S100A4; this interaction increases cell motility. Q8VDD5; Q923J1: Trpm7; NbExp=4; IntAct=EBI-400906, EBI-8010314; Cytoplasm, cytoskeleton Cytoplasm, cell cortex Cytoplasmic vesicle, secretory vesicle, Cortical granule Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (By similarity). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (By similarity). In neonatal mouse cochlea, weak levels of expression in both hair cells and supporting cells (at protein level). In the cochlea of six day old mice, expression is restricted to hair cell sterocilia (at protein level). The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. ISGylated. Ubiquitination. Reduced litter size and increased polyspermy in the perivitelline space following fertilization. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Sequence=BAE27768.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; microfilament motor activity nucleotide binding meiotic spindle organization cell morphogenesis involved in differentiation angiogenesis in utero embryonic development stress fiber ruffle establishment of T cell polarity immunological synapse plasma membrane repair uropod motor activity actin binding integrin binding protein binding calmodulin binding ATP binding nucleus cytoplasm actomyosin contractile ring cytosol cytoskeleton plasma membrane brush border cell-cell adherens junction cell cortex membrane protein ectodomain proteolysis phagocytosis, engulfment cell adhesion myoblast fusion COP9 signalosome regulation of cell shape protein transport actin cytoskeleton myosin complex myosin II complex ATPase activity protein domain specific binding actin filament-based movement platelet formation monocyte differentiation cortical cytoskeleton actin-dependent ATPase activity actomyosin structure organization cell leading edge actin cytoskeleton reorganization cleavage furrow lysosome localization cytokinetic process uropod organization macromolecular complex actomyosin protein homodimerization activity protein anchor ADP binding blood vessel endothelial cell migration regulated exocytosis actin filament binding establishment of meiotic spindle localization myosin II filament cell-cell adhesion negative regulation of actin filament severing positive regulation of protein processing in phagocytic vesicle regulation of plasma membrane repair spindle focal adhesion neuromuscular junction actin filament polymerization actin filament capping uc007woc.1 uc007woc.2 uc007woc.3 uc007woc.4 
ENSMUST00000016781.8 Ift27 ENSMUST00000016781.8 intraflagellar transport 27 (from RefSeq NM_025931.3) ENSMUST00000016781.1 ENSMUST00000016781.2 ENSMUST00000016781.3 ENSMUST00000016781.4 ENSMUST00000016781.5 ENSMUST00000016781.6 ENSMUST00000016781.7 IFT27_MOUSE NM_025931 Q9D0P8 Rabl4 Rayl uc007wor.1 uc007wor.2 uc007wor.3 Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25446516). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling (PubMed:25446516). Forms a subcomplex within the IFT complex B with IFT25 (By similarity). Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation (PubMed:28964737). Plays a role in the early development of the kidney (PubMed:29626631). May be involved in the regulation of ureteric bud initiation (PubMed:29626631). Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (PubMed:19253336). Interacts with IFT25 (PubMed:28430876). Interacts with IFT70B (PubMed:23810713). Interacts with RABL2/RABL2A; binding is equal in the presence of GTP or GDP (PubMed:23055941). Interacts with IFT88 (PubMed:19253336). Interacts with ARL6; recognizes and binds with the GTP-free form of ARL6 (By similarity). Cell projection, cilium Cytoplasm Cell projection, cilium, flagellum Note=Localizes to the sperm flagellum. Expressed predominantly in the testis (at protein level) (PubMed:28964737). Co-localizes with RABL2/RABL2A in the midpiece of elongated spermatids within the testis (at protein level). Null mutants retain the ability to ciliate and survive through gestation. They die shortly after birth due to different phenotypes reminiscent of Shh signaling defects: polydactyly, lung isomerisms, and structural heart defects (PubMed:25446516). Conditional knockout in male germ cells results in infertility, abnormal sperm morphology, significantly reduced sperm count and sperm mobility (PubMed:28964737). Mutant mice with germline deletion of IFT27 die shortly after birth with structural defects in most organs including the kidneys, where duplicated collecting duct system and/or duplex kidney is often observed. Conditional deletion in the collecting duct results in smaller kidneys that develop only mild tubule dilation with age whereas conditional deletion from the peri-Wolffian duct stroma results in duplex kidneys (PubMed:29626631). Belongs to the small GTPase superfamily. Rab family. nucleotide binding kidney development GTPase activity protein binding GTP binding cytoplasm centrosome cilium intracellular protein transport signal transduction smoothened signaling pathway spermatogenesis protein transport membrane cell differentiation intraciliary transport particle B motile cilium Rab protein signal transduction sperm flagellum intraciliary transport cell projection inner ear receptor stereocilium organization cochlea development sperm midpiece sperm principal piece uc007wor.1 uc007wor.2 uc007wor.3 
ENSMUST00000016897.12 Ttll1 ENSMUST00000016897.12 tubulin tyrosine ligase-like 1, transcript variant 1 (from RefSeq NM_178869.4) ENSMUST00000016897.1 ENSMUST00000016897.10 ENSMUST00000016897.11 ENSMUST00000016897.2 ENSMUST00000016897.3 ENSMUST00000016897.4 ENSMUST00000016897.5 ENSMUST00000016897.6 ENSMUST00000016897.7 ENSMUST00000016897.8 ENSMUST00000016897.9 NM_178869 Q3TGC8 Q543S4 Q8C0A2 Q91V51 Q91ZG1 TTLL1_MOUSE Ttll1 uc007xbc.1 uc007xbc.2 uc007xbc.3 uc007xbc.4 Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:15890843). Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step (Probable). Modifies both alpha- and beta-tubulins with a preference for the alpha-tail (PubMed:15890843, PubMed:22170066). Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity (PubMed:15890843). Part of the neuronal tubulin polyglutamylase complex (PubMed:15890843). Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility (PubMed:20498047, PubMed:20442420, PubMed:23897886). Involved in respiratory motile cilia function through the regulation of beating asymmetry (PubMed:20498047, PubMed:20442420). Essential for sperm flagella biogenesis, motility and male fertility (PubMed:20442420). Also mediates glutamylation of non- tubulin proteins (PubMed:29593216). Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis (PubMed:29593216). Reaction=(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60148, Rhea:RHEA-COMP:15519, Rhea:RHEA-COMP:15675, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143623, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60149; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1, CSTPP1 and LRRC49 (By similarity). Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, cilium axoneme Cell projection, cilium, flagellum Highly expressed in brain, heart and kidney (PubMed:17499049, PubMed:20442420). Expressed in liver, lung, muscle, spleen, testis and trachea (PubMed:17499049, PubMed:20442420). In the brain, expressed in ependymal cilia, cortex, corpus callosum and striatum (PubMed:23897886). Expressed in blastomere (PubMed:29593216). Gln-144 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate- chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation. Knockout mice exhibit a loss of axonemal curvature and beating asymmetry in tracheal epithelial cilia, resulting in a reduction of cilia-generated fluid flow in trachea (PubMed:20498047). Knockout mice exhibit accumulations of exudates in the nasal passages and sinuses, rhinosinusitis and otitis media, and also emitted frequent coughing- or sneezing-like noises (PubMed:20498047, PubMed:20442420). Knockout male show abnormal sperm morphology and function characterized by shortened or absent flagella and immotility, and male infertility (PubMed:20498047, PubMed:20442420). Partial loss of tubulin glutamylation, probably due to redundancy with other polyglutamylases (PubMed:20498047). Belongs to the tubulin polyglutamylase family. nucleotide binding epithelial cilium movement protein binding ATP binding cellular_component extracellular region cytoplasm cytosol cytoskeleton microtubule cellular protein modification process sperm axoneme assembly ligase activity protein polyglutamylation axoneme assembly tubulin-glutamic acid ligase activity sperm flagellum movement involved in flagellated sperm motility uc007xbc.1 uc007xbc.2 uc007xbc.3 uc007xbc.4 
ENSMUST00000016901.5 Ttll12 ENSMUST00000016901.5 tubulin tyrosine ligase-like family, member 12 (from RefSeq NM_183017.2) ENSMUST00000016901.1 ENSMUST00000016901.2 ENSMUST00000016901.3 ENSMUST00000016901.4 NM_183017 Q3UDE2 Q7TPC3 TTL12_MOUSE Ttll12 uc007xbh.1 uc007xbh.2 uc007xbh.3 uc007xbh.4 Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE. Interacts with MAVS; the interaction prevents MAVS binding to TBK1 and IKBKE. Interacts (via N-terminus) with TBK1 (via protein kinase domain). Interacts (via TTL domain) with IKBKE (via protein kinase domain). Interacts with tubulin alpha. Interacts with histone H3 and histone H4 (when trimethylated at 'Lys-20' (H4K20me3)). Interacts with CBX3. Cytoplasm Midbody Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Nucleus Note=Predominantly localizes in the cytoplasm. Widely expressed with highest levels in brain, kidney, liver, lung, muscle and testis. Belongs to the tubulin--tyrosine ligase family. Although it belongs to the tubulin--tyrosine ligase family, the TTL domain lacks some of the ATP binding sites predicted to be essential for TTL activity (By similarity). Lacks tyrosine ligase activity in vitro (By similarity). Lacks glutamylation activity in vitro (PubMed:17499049). Although TTLL12 contains a potential SET-like domain in the N-terminus, it does not have lysine methyltransferase activity towards histone in vitro (By similarity). nucleotide binding ATP binding cytoplasm cellular protein modification process regulation of mitotic cell cycle tubulin binding negative regulation of type I interferon-mediated signaling pathway H4K20me3 modified histone binding uc007xbh.1 uc007xbh.2 uc007xbh.3 uc007xbh.4 
ENSMUST00000016902.5 Bik ENSMUST00000016902.5 BCL2-interacting killer (from RefSeq NM_007546.2) BIK_MOUSE Biklk Blk ENSMUST00000016902.1 ENSMUST00000016902.2 ENSMUST00000016902.3 ENSMUST00000016902.4 NM_007546 Nbk O70337 uc007xbd.1 uc007xbd.2 uc007xbd.3 Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1 or Bcl-2 suppresses this death-promoting activity. Interacts with RHBDL4/RHBDD1 (By similarity). Interacts with BCL2L10/BCL-B (By similarity). Endomembrane system ; Single-pass membrane protein Mitochondrion membrane ; Single-pass membrane protein Note=Around the nuclear envelope, and in cytoplasmic membranes. Expressed in testis, kidney, liver, lung and heart. Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti- apoptotic members of the Bcl-2 family. Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome- dependent mechanism (By similarity). protein binding mitochondrion mitochondrial envelope apoptotic process spermatogenesis male gonad development apoptotic mitochondrial changes endomembrane system membrane integral component of membrane mitochondrial membrane positive regulation of protein homooligomerization protein heterodimerization activity BH domain binding positive regulation of release of cytochrome c from mitochondria uc007xbd.1 uc007xbd.2 uc007xbd.3 
ENSMUST00000016951.8 Serpinb1b ENSMUST00000016951.8 serine (or cysteine) peptidase inhibitor, clade B, member 1b (from RefSeq NM_173052.2) ENSMUST00000016951.1 ENSMUST00000016951.2 ENSMUST00000016951.3 ENSMUST00000016951.4 ENSMUST00000016951.5 ENSMUST00000016951.6 ENSMUST00000016951.7 ILEUB_MOUSE NM_173052 Q8VHP7 uc007qab.1 uc007qab.2 uc007qab.3 uc007qab.4 Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G (PubMed:12189154). During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). Monomer. Interacts (via C-terminus) with CASP1 and CASP4 (via CARD domain); these interactions regulate the activity of inflammatory caspases. Cytoplasm Expressed in brain with lower expression in lung, spleen and testis. Belongs to the serpin family. Ov-serpin subfamily. serine-type endopeptidase inhibitor activity protein binding extracellular space cytoplasm negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity regulation of protein catabolic process negative regulation of interleukin-1 beta secretion uc007qab.1 uc007qab.2 uc007qab.3 uc007qab.4 
ENSMUST00000016977.15 Mrps18c ENSMUST00000016977.15 mitochondrial ribosomal protein S18C (from RefSeq NM_026826.1) ENSMUST00000016977.1 ENSMUST00000016977.10 ENSMUST00000016977.11 ENSMUST00000016977.12 ENSMUST00000016977.13 ENSMUST00000016977.14 ENSMUST00000016977.2 ENSMUST00000016977.3 ENSMUST00000016977.4 ENSMUST00000016977.5 ENSMUST00000016977.6 ENSMUST00000016977.7 ENSMUST00000016977.8 ENSMUST00000016977.9 NM_026826 Q3UKN5 Q8R2L5 Q9D100 RT18C_MOUSE uc008yib.1 uc008yib.2 uc008yib.3 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the bacterial ribosomal protein bS18 family. structural constituent of ribosome mitochondrion mitochondrial small ribosomal subunit ribosome translation small ribosomal subunit rRNA binding uc008yib.1 uc008yib.2 uc008yib.3 
ENSMUST00000017090.6 Kctd5 ENSMUST00000017090.6 potassium channel tetramerisation domain containing 5 (from RefSeq NM_027008.2) A0A0R4J000 A0A0R4J000_MOUSE ENSMUST00000017090.1 ENSMUST00000017090.2 ENSMUST00000017090.3 ENSMUST00000017090.4 ENSMUST00000017090.5 Kctd5 NM_027008 uc008auh.1 uc008auh.2 uc008auh.3 uc008auh.4 cytosol identical protein binding macromolecular complex binding protein homooligomerization uc008auh.1 uc008auh.2 uc008auh.3 uc008auh.4 
ENSMUST00000017142.3 Svs4 ENSMUST00000017142.3 seminal vesicle secretory protein 4 (from RefSeq NM_009300.3) A2A4C3 ENSMUST00000017142.1 ENSMUST00000017142.2 NM_009300 P18419 Q14BU4 Q9D257 SVS4_MOUSE Svp2 uc008nue.1 uc008nue.2 uc008nue.3 Secreted, extracellular space. Testis. By testosterone. Belongs to the SVP2/SVP5/SVP6 family. extracellular region extracellular space uc008nue.1 uc008nue.2 uc008nue.3 
ENSMUST00000017144.3 Svs6 ENSMUST00000017144.3 seminal vesicle secretory protein 6 (from RefSeq NM_013679.2) ENSMUST00000017144.1 ENSMUST00000017144.2 NM_013679 Q9D268 Q9D268_MOUSE Svs6 uc008nuh.1 uc008nuh.2 uc008nuh.3 Secreted, extracellular space Belongs to the SVP2/SVP5/SVP6 family. uc008nuh.1 uc008nuh.2 uc008nuh.3 
ENSMUST00000017147.8 Svs3a ENSMUST00000017147.8 seminal vesicle secretory protein 3A, transcript variant 1 (from RefSeq NM_021363.2) ENSMUST00000017147.1 ENSMUST00000017147.2 ENSMUST00000017147.3 ENSMUST00000017147.4 ENSMUST00000017147.5 ENSMUST00000017147.6 ENSMUST00000017147.7 F2Z467 F2Z472 NM_021363 Q8VI13 Q9JKD2 SVS3A_MOUSE Svs3 Svs3a uc008nuf.1 uc008nuf.2 uc008nuf.3 uc008nuf.4 uc008nuf.5 Component of the copulatory plug. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=F2Z472-1; Sequence=Displayed; Name=2; IsoId=F2Z472-2; Sequence=VSP_059284; Highly expressed in the seminal vesicle where it is detected in luminal epithelium of the mucosa folds, and also in luminal fluid (at protein level). Not detected in other tissues tested. First detected at 3 weeks of age. Expression increases through to 6 weeks of age and remains high thereafter. Up-regulated in response to androgens. Glycosylated. Covalently cross-linked by transglutaminase, which is important for the formation of the gelatinous copulatory plug. Five repeats of Q- X-K-(S/T) in the central region of the protein serve as the transglutaminase substrate site(s). [Isoform 2]: May be due to competing acceptor splice site. molecular_function extracellular region mating plug formation sperm capacitation uc008nuf.1 uc008nuf.2 uc008nuf.3 uc008nuf.4 uc008nuf.5 
ENSMUST00000017148.8 Svs5 ENSMUST00000017148.8 seminal vesicle secretory protein 5 (from RefSeq NM_009301.2) ENSMUST00000017148.1 ENSMUST00000017148.2 ENSMUST00000017148.3 ENSMUST00000017148.4 ENSMUST00000017148.5 ENSMUST00000017148.6 ENSMUST00000017148.7 NM_009301 Q545K7 Q545K7_MOUSE Svs5 uc008nui.1 uc008nui.2 uc008nui.3 Secreted, extracellular space Belongs to the SVP2/SVP5/SVP6 family. uc008nui.1 uc008nui.2 uc008nui.3 
ENSMUST00000017151.2 Rbpjl ENSMUST00000017151.2 recombination signal binding protein for immunoglobulin kappa J region-like (from RefSeq NM_009036.1) ENSMUST00000017151.1 NM_009036 Q3V2I2 Q3V2I2_MOUSE Rbpjl Rbpsuhl uc008nup.1 uc008nup.2 Nucleus Belongs to the Su(H) family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter uc008nup.1 uc008nup.2 
ENSMUST00000017153.4 Sdc4 ENSMUST00000017153.4 syndecan 4 (from RefSeq NM_011521.2) ENSMUST00000017153.1 ENSMUST00000017153.2 ENSMUST00000017153.3 NM_011521 Q3U5S6 Q3U5S6_MOUSE Sdc4 uc008nuq.1 uc008nuq.2 uc008nuq.3 Cell surface proteoglycan. Membrane ingle-pass type I membrane protein Belongs to the syndecan proteoglycan family. ureteric bud development fibronectin binding protein kinase C binding focal adhesion cell surface membrane integral component of membrane negative regulation of T cell proliferation identical protein binding costamere membrane raft positive regulation of protein kinase activity positive regulation of stress fiber assembly positive regulation of focal adhesion assembly thrombospondin receptor activity positive regulation of exosomal secretion positive regulation of extracellular exosome assembly uc008nuq.1 uc008nuq.2 uc008nuq.3 
ENSMUST00000017208.5 Prl5a1 ENSMUST00000017208.5 prolactin family 5, subfamily a, member 1 (from RefSeq NM_023746.4) D13Wsu14e ENSMUST00000017208.1 ENSMUST00000017208.2 ENSMUST00000017208.3 ENSMUST00000017208.4 NM_023746 PR5A1_MOUSE Prlpl Q80X20 Q9JII2 uc007pyh.1 uc007pyh.2 uc007pyh.3 Secreted Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pyh.1 uc007pyh.2 uc007pyh.3 
ENSMUST00000017255.4 Krt24 ENSMUST00000017255.4 keratin 24 (from RefSeq NM_029393.2) A1L316 A1L317 ENSMUST00000017255.1 ENSMUST00000017255.2 ENSMUST00000017255.3 K1C24_MOUSE Ka24 NM_029393 Q8BKC6 uc007lim.1 uc007lim.2 uc007lim.3 Heterotetramer of two type I and two type II keratins. There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively). Belongs to the intermediate filament family. structural molecule activity intermediate filament biological_process uc007lim.1 uc007lim.2 uc007lim.3 
ENSMUST00000017270.8 Krt42 ENSMUST00000017270.8 keratin 42 (from RefSeq NM_212483.3) A7MAW4 ENSMUST00000017270.1 ENSMUST00000017270.2 ENSMUST00000017270.3 ENSMUST00000017270.4 ENSMUST00000017270.5 ENSMUST00000017270.6 ENSMUST00000017270.7 K1C42_MOUSE Ka22 Krt42 NM_212483 Q2M1G8 Q6IFX2 Q6SEK1 uc007lku.1 uc007lku.2 uc007lku.3 Heterodimer of a type I and a type II keratin. Colocalizes with KRT8/KRT18 filament network. Cytoplasm Expressed in nail matrix and nail bed epithelium (at protein level). Also expressed in tongue and digits with weak expression in vibrissae and in both filiform and fungiform papillae of oral mucosa. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. structural molecule activity cytoplasm intermediate filament biological_process uc007lku.1 uc007lku.2 uc007lku.3 
ENSMUST00000017276.14 Cyth1 ENSMUST00000017276.14 cytohesin 1, transcript variant 1 (from RefSeq NM_011180.4) CYH1_MOUSE ENSMUST00000017276.1 ENSMUST00000017276.10 ENSMUST00000017276.11 ENSMUST00000017276.12 ENSMUST00000017276.13 ENSMUST00000017276.2 ENSMUST00000017276.3 ENSMUST00000017276.4 ENSMUST00000017276.5 ENSMUST00000017276.6 ENSMUST00000017276.7 ENSMUST00000017276.8 ENSMUST00000017276.9 NM_011180 O88817 Pscd1 Q76MU4 Q9QX11 uc011yil.1 uc011yil.2 uc011yil.3 Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6 (PubMed:18042453, PubMed:20080746). Promotes the activation of ARF factors through replacement of GDP with GTP (PubMed:18042453). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity (PubMed:20080746, PubMed:29420262). Interacts with TRIM23 and CYTIP (By similarity). Interacts (via coiled-coil domain) with FRMD4A (via coiled-coil domain)(PubMed:20080746). Interacts with FRMD4B (PubMed:20080746). Found in a complex with PARD3, CYTH1 and FRMD4A (PubMed:20080746). Interacts (via N-terminal domain) with INAVA (via N-terminal domain) (By similarity). Cell membrane eripheral membrane protein Cytoplasm, cytosol Cell junction, tight junction Cell junction, adherens junction Note=Colocalized with TJP1 during epithelial polarization (PubMed:20080746). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QX11-1; Sequence=Displayed; Name=2; IsoId=Q9QX11-2; Sequence=VSP_006035; Expressed in colon and small intestine (at protein level). Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate. Autoinhibited by its C-terminal basic region. Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation. guanyl-nucleotide exchange factor activity ARF guanyl-nucleotide exchange factor activity protein binding cytoplasm cytosol plasma membrane adherens junction bicellular tight junction lipid binding membrane cell junction extrinsic component of cytoplasmic side of plasma membrane neuromuscular junction regulation of ARF protein signal transduction establishment of epithelial cell polarity extrinsic component of presynaptic membrane regulation of synaptic vesicle exocytosis uc011yil.1 uc011yil.2 uc011yil.3 
ENSMUST00000017288.9 Rnd3 ENSMUST00000017288.9 Rho family GTPase 3 (from RefSeq NM_028810.2) Arhe ENSMUST00000017288.1 ENSMUST00000017288.2 ENSMUST00000017288.3 ENSMUST00000017288.4 ENSMUST00000017288.5 ENSMUST00000017288.6 ENSMUST00000017288.7 ENSMUST00000017288.8 NM_028810 P52199 P61588 Q6ZWS2 RND3_MOUSE Rhoe uc008jqf.1 uc008jqf.2 uc008jqf.3 Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Interacts with UBXD5 (By similarity). Binds ROCK1. P61588; P70335: Rock1; NbExp=7; IntAct=EBI-6930266, EBI-989293; P61588; Q13017: ARHGAP5; Xeno; NbExp=2; IntAct=EBI-6930266, EBI-7237884; P61588; P31946: YWHAB; Xeno; NbExp=5; IntAct=EBI-6930266, EBI-359815; P61588; P62258: YWHAE; Xeno; NbExp=2; IntAct=EBI-6930266, EBI-356498; P61588; P61981: YWHAG; Xeno; NbExp=2; IntAct=EBI-6930266, EBI-359832; P61588; Q04917: YWHAH; Xeno; NbExp=2; IntAct=EBI-6930266, EBI-306940; P61588; P27348: YWHAQ; Xeno; NbExp=2; IntAct=EBI-6930266, EBI-359854; P61588; P63104: YWHAZ; Xeno; NbExp=3; IntAct=EBI-6930266, EBI-347088; Golgi apparatus membrane ; Peripheral membrane protein Ubiquitous. Belongs to the small GTPase superfamily. Rho family. Golgi membrane nucleotide binding GTPase activity protein binding GTP binding cytoplasm Golgi apparatus cell cortex actin filament organization small GTPase mediated signal transduction Rho protein signal transduction regulation of cell shape membrane protein kinase binding regulation of cell migration establishment or maintenance of actin cytoskeleton polarity cell division site regulation of actin cytoskeleton organization intracellular membrane-bounded organelle actin filament bundle assembly plasma membrane uc008jqf.1 uc008jqf.2 uc008jqf.3 
ENSMUST00000017290.11 Brca1 ENSMUST00000017290.11 breast cancer 1, early onset (from RefSeq NM_009764.3) A2A4Q4 BRCA1_MOUSE ENSMUST00000017290.1 ENSMUST00000017290.10 ENSMUST00000017290.2 ENSMUST00000017290.3 ENSMUST00000017290.4 ENSMUST00000017290.5 ENSMUST00000017290.6 ENSMUST00000017290.7 ENSMUST00000017290.8 ENSMUST00000017290.9 NM_009764 P48754 Q60957 Q60983 uc007lpd.1 uc007lpd.2 uc007lpd.3 uc007lpd.4 E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine- tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1- mediated ubiquitination of RBBP8. Acts as a transcriptional activator. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1 (By similarity). Interacts with EXD2 (By similarity). Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme (By similarity). Interacts with DNA helicase ZGRF1; the interaction is increased following DNA damage induction (By similarity). Nucleus Chromosome Cytoplasm Note=Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex. Translocated to the cytoplasm during UV-induced apoptosis. In the embryo, expressed in otic vesicles at day 9.5. At day 10.5, this expression decreases and high levels are found in the neuroectoderm. At days 11-12.5, high levels in differentiating keratinocytes and whisker pad primordia. At days 14-17, expression also observed in kidney epithelial cells. In the adult, highest levels found in spleen, thymus, lymph nodes, epithelial organs, and alveolar and ductal epithelial cells of the mammary gland. Very low levels in brain, kidney, and skin. No expression in heart, liver or lung. In the mammary gland, expression increases dramatically during pregnancy. Levels fall during lactation and increase again during post-lactational regression of the mammary gland. The BRCT domains recognize and bind phosphorylated pSXXF motif on proteins. The interaction with the phosphorylated pSXXF motif of ABRAXAS1, recruits BRCA1 at DNA damage sites. The RING-type zinc finger domain interacts with BAP1. Phosphorylated in response to IR, UV, and various stimuli that cause checkpoint activation, probably by ATM or ATR. Phosphorylation at Ser-971 by CHEK2 regulates mitotic spindle assembly. Phosphorylation by AURKA regulates centrosomal microtubule nucleation. Autoubiquitinated, undergoes 'Lys-6'-linked polyubiquitination. 'Lys-6'-linked polyubiquitination does not promote degradation. double-strand break repair via homologous recombination condensed chromosome condensed nuclear chromosome lateral element DNA binding chromatin binding damaged DNA binding transcription coactivator activity RNA binding ubiquitin-protein transferase activity nucleus nucleoplasm chromosome cytoplasm mitochondrial matrix centrosome plasma membrane DNA repair postreplication repair double-strand break repair DNA recombination regulation of gene expression by genetic imprinting regulation of transcription from RNA polymerase II promoter lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process cellular response to DNA damage stimulus cell cycle chromosome segregation centrosome cycle zinc ion binding intrinsic apoptotic signaling pathway in response to DNA damage dosage compensation by inactivation of X chromosome response to ionizing radiation positive regulation of vascular endothelial growth factor production positive regulation of gene expression protein ubiquitination transferase activity enzyme binding positive regulation of protein ubiquitination BRCA1-BARD1 complex ubiquitin protein ligase binding macromolecular complex negative regulation of intracellular estrogen receptor signaling pathway positive regulation of histone acetylation negative regulation of histone acetylation identical protein binding chordate embryonic development response to estrogen regulation of DNA methylation transcription regulatory region DNA binding mitotic G2/M transition checkpoint negative regulation of fatty acid biosynthetic process positive regulation of DNA repair positive regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding centrosome duplication positive regulation of histone H3-K4 methylation negative regulation of histone H3-K4 methylation negative regulation of histone H3-K9 methylation positive regulation of histone H3-K9 methylation protein autoubiquitination RNA polymerase binding positive regulation of histone H4-K20 methylation BRCA1-A complex positive regulation of cell cycle arrest cellular response to tumor necrosis factor cellular response to indole-3-methanol signal transduction involved in G2 DNA damage checkpoint protein K6-linked ubiquitination negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ribonucleoprotein complex negative regulation of reactive oxygen species metabolic process positive regulation of histone H3-K9 acetylation positive regulation of histone H4-K16 acetylation uc007lpd.1 uc007lpd.2 uc007lpd.3 uc007lpd.4 
ENSMUST00000017309.2 Gast ENSMUST00000017309.2 gastrin (from RefSeq NM_010257.4) ENSMUST00000017309.1 GAST_MOUSE Gas NM_010257 P48757 P70334 Q64295 Q9CPR2 uc007lkw.1 uc007lkw.2 uc007lkw.3 uc007lkw.4 uc007lkw.5 This gene encodes the peptide hormone gastrin, which stimulates gastric acid secretion, proliferation, cell migration and angiogenesis, as well as inhibits apoptosis. The encoded preproprotein undergoes proteolytic processing to generate multiple gastrin peptides differing in size. Mice lacking the encoded protein exhibit a decrease in the number of parietal cells, achlorohydria and a decrease in the colonic proliferation. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X94758.1, AK008062.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. Secreted. Abundantly expressed in the stomach and duodenum. Low levels in brain, ovary and pancreas. Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins and between tissues (By similarity). Belongs to the gastrin/cholecystokinin family. hormone activity protein binding extracellular region extracellular space signal transduction G-protein coupled receptor signaling pathway response to food uc007lkw.1 uc007lkw.2 uc007lkw.3 uc007lkw.4 uc007lkw.5 
ENSMUST00000017332.4 Coa3 ENSMUST00000017332.4 cytochrome C oxidase assembly factor 3 (from RefSeq NM_026618.2) A2A4J6 COA3_MOUSE Ccdc56 ENSMUST00000017332.1 ENSMUST00000017332.2 ENSMUST00000017332.3 NM_026618 Q9D2R6 uc007log.1 uc007log.2 uc007log.3 Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly. Along with COX14, core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Interacts with MT-CO1/COX1, SMIM20, SURF1 and TIMM21. Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the COA3 family. molecular_function mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex IV membrane integral component of membrane integral component of mitochondrial inner membrane mitochondrial respiratory chain complex IV assembly positive regulation of mitochondrial translation uc007log.1 uc007log.2 uc007log.3 
ENSMUST00000017339.12 Zpbp2 ENSMUST00000017339.12 zona pellucida binding protein 2, transcript variant 1 (from RefSeq NM_027061.2) A2A4Y0 ENSMUST00000017339.1 ENSMUST00000017339.10 ENSMUST00000017339.11 ENSMUST00000017339.2 ENSMUST00000017339.3 ENSMUST00000017339.4 ENSMUST00000017339.5 ENSMUST00000017339.6 ENSMUST00000017339.7 ENSMUST00000017339.8 ENSMUST00000017339.9 NM_027061 Q6X785 Q6X786 Q9DA91 ZPBP2_MOUSE uc007lgp.1 uc007lgp.2 uc007lgp.3 uc007lgp.4 Is implicated in sperm-oocyte interaction during fertilization. Cytoplasmic vesicle, secretory vesicle, acrosome Secreted Note=Released after the acrosomal reaction. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6X786-1; Sequence=Displayed; Name=2; IsoId=Q6X786-2; Sequence=VSP_011685; Name=3; IsoId=Q6X786-3; Sequence=VSP_011684; Expressed specifically in male germ cells. Expressed from the mid-pachytene spermatocyte stage to the early elongating spermatid stage. N-glycosylated. Male mice are subfertile with sperm showing reduced ability to penetrate zona pellucida and displaying subtle morphological deformation, including shortened apical hook, smaller apical angle and bulges in acrosome region. Belongs to the zona pellucida-binding protein Sp38 family. acrosomal vesicle acrosome assembly zona pellucida receptor complex molecular_function extracellular region binding of sperm to zona pellucida cytoplasmic vesicle cell body uc007lgp.1 uc007lgp.2 uc007lgp.3 uc007lgp.4 
ENSMUST00000017348.3 Gsdma ENSMUST00000017348.3 gasdermin A (from RefSeq NM_021347.4) A3KFN3 ENSMUST00000017348.1 ENSMUST00000017348.2 GSDMA_MOUSE Gsdm Gsdm1 Gsdma1 NM_021347 Q9EST1 uc007lgv.1 uc007lgv.2 [Gasdermin-A]: This form constitutes the precursor of the pore-forming protein and acts as a sensor of bacterial infection: upon infection, specifically cleaved by bacterial effector protein SpeB in epithelial cells, releasing the N-terminal moiety (Gasdermin-A, N- terminal) that binds to membranes and forms pores, triggering pyroptosis. [Gasdermin-A, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:35110732). Released upon cleavage by bacterial effector protein SpeB, and binds to membrane inner leaflet lipids (PubMed:35110732). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (By similarity). Pyroptosis triggers the elimination of the infected skin cell, depriving the pathogen of its protective niche, while inducing an inflammatory response (PubMed:35110732, PubMed:35545676). This ultimately prevents bacterial penetration of the epithelial barrier and a subsequent systemic dissemination of the pathogen (PubMed:35110732, PubMed:35545676). Binds to cardiolipin and other acidic phospholipids, such as phosphatidylserine, which mediate its targeting to the inner leaflet membrane (By similarity). [Gasdermin-A]: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C- terminal domains mediate autoinhibition in the absence of activation signal (By similarity). The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-A, N-terminal) following cleavage by bacterial effector protein SpeB (PubMed:35110732). [Gasdermin-A, N-terminal]: Homooligomer; homooligomeric ring- shaped pore complex containing 18-36 subunits when inserted in the membrane. [Gasdermin-A]: Cytoplasm, perinuclear region Cytoplasm, cytosol [Gasdermin-A, N-terminal]: Cell membrane ; Multi-pass membrane protein Expressed predominantly in the gastrointestinal (GI) tract and in the skin at a lower level. In the GI tract, the expression is highly restricted to the esophagus and forestomach. Expression is first detected at 12.5 dpc. Intramolecular interactions between N- and C-terminal domains are important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain. Cleavage by bacterial SpeB relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-A, N-terminal) that initiates pyroptosis. Mice are highly susceptible to subcutaneous group A Streptococcus (GAS) infection in an animal model (PubMed:35110732). Mice lacking Gsdma, Gsdma2 and Gsdma3 are highly susceptible to subcutaneous group A Streptococcus (GAS) infection in an animal model (PubMed:35545676). Belongs to the gasdermin family. phosphatidylserine binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm cytosol plasma membrane apoptotic process programmed cell death membrane perinuclear region of cytoplasm pyroptosis phosphatidylinositol-4-phosphate binding uc007lgv.1 uc007lgv.2 
ENSMUST00000017354.13 Med24 ENSMUST00000017354.13 mediator complex subunit 24, transcript variant 3 (from RefSeq NM_011869.3) A3KFP0 D11Ertd307e ENSMUST00000017354.1 ENSMUST00000017354.10 ENSMUST00000017354.11 ENSMUST00000017354.12 ENSMUST00000017354.2 ENSMUST00000017354.3 ENSMUST00000017354.4 ENSMUST00000017354.5 ENSMUST00000017354.6 ENSMUST00000017354.7 ENSMUST00000017354.8 ENSMUST00000017354.9 MED24_MOUSE NM_011869 Q8R004 Q99K74 Q9D277 Q9WVF1 Thrap4 Trap100 uc007lha.1 uc007lha.2 This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for basal and activator-dependent transcription. Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR (By similarity). Interacts with MED1 and MED10. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99K74-1; Sequence=Displayed; Name=2; IsoId=Q99K74-2; Sequence=VSP_028355, VSP_028356; Name=3; IsoId=Q99K74-3; Sequence=VSP_028357, VSP_028358; Expressed in the adrenal gland, brain, epididymis, heart, kidney, liver, ovary, pancreas, prostate, skeletal muscle, small intestine, spleen, stomach, testis and thymus. Expressed throughout development; expression levels drop immediately after birth. Strongly expressed throughout the primitive nervous system, the hepatic primoridium and the earliest limb buds. Belongs to the Mediator complex subunit 24 family. ubiquitin ligase complex transcription cofactor activity transcription coactivator activity histone acetyltransferase activity nucleus nucleoplasm transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter protein ubiquitination histone acetylation mediator complex stem cell population maintenance positive regulation of transcription, DNA-templated thyroid hormone receptor binding protein heterooligomerization ubiquitin protein ligase activity uc007lha.1 uc007lha.2 
ENSMUST00000017365.15 Psmd3 ENSMUST00000017365.15 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 (from RefSeq NM_009439.1) ENSMUST00000017365.1 ENSMUST00000017365.10 ENSMUST00000017365.11 ENSMUST00000017365.12 ENSMUST00000017365.13 ENSMUST00000017365.14 ENSMUST00000017365.2 ENSMUST00000017365.3 ENSMUST00000017365.4 ENSMUST00000017365.5 ENSMUST00000017365.6 ENSMUST00000017365.7 ENSMUST00000017365.8 ENSMUST00000017365.9 NM_009439 P14685 P91a PSMD3_MOUSE Q3TP95 Q99LL7 Tstap91a uc007lgx.1 uc007lgx.2 uc007lgx.3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the 19S proteasome regulatory particle complex (PubMed:16857966). The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (By similarity). The regulatory particle is made of a lid composed of 9 subunits including PSMD3, a base containing 6 ATPases and few additional components (By similarity). Interacts with UBQLN1 (via ubiquitin-like domain) (By similarity). Interacts with ERCC6 (By similarity). Belongs to the proteasome subunit S3 family. proteasome complex protein binding proteasome regulatory particle ubiquitin-dependent protein catabolic process proteasome regulatory particle, lid subcomplex proteasome accessory complex enzyme regulator activity regulation of protein catabolic process regulation of catalytic activity uc007lgx.1 uc007lgx.2 uc007lgx.3 
ENSMUST00000017384.14 Casc3 ENSMUST00000017384.14 Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon- exon junctions. Binds poly(G) and poly(U) RNA homomer. (from UniProt Q8K3W3) A3KFP7 AJ292072 CASC3_MOUSE ENSMUST00000017384.1 ENSMUST00000017384.10 ENSMUST00000017384.11 ENSMUST00000017384.12 ENSMUST00000017384.13 ENSMUST00000017384.2 ENSMUST00000017384.3 ENSMUST00000017384.4 ENSMUST00000017384.5 ENSMUST00000017384.6 ENSMUST00000017384.7 ENSMUST00000017384.8 ENSMUST00000017384.9 Mln51 Q3UT99 Q8K219 Q8K3W3 Q99NF0 uc011yeh.1 uc011yeh.2 uc011yeh.3 Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon- exon junctions. Binds poly(G) and poly(U) RNA homomer. Identified in the spliceosome C complex. Component of the mRNA splicing-dependent exon junction complex (EJC), which contains at least CASC3, EIF4A3, MAGOH, NXF1 and RBM8A/Y14. Identified in a complex composed of the EJC core, UPF3B and UPF2. The EJC core can also interact with UPF3A (in vitro) (By similarity). Forms homooligomers (By similarity). Interacts with STAU in an RNA-dependent manner (PubMed:12843282). Interacts with DHX34; the interaction is RNA- independent (By similarity). Cytoplasm Cytoplasm, perinuclear region Nucleus Nucleus speckle Cytoplasm, Stress granule Cytoplasm, Cytoplasmic ribonucleoprotein granule Cell projection, dendrite Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (PubMed:12843282). Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. In nuclear speckles, colocalizes with MAGOH. Under stress conditions, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules (By similarity). In the dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (Probable). High levels in heart, brain, including hippocampus and cerebellum, liver, kidney and testis; lower levels in muscle, lung and spleen. The coiled coil domain may be involved in oligomerization. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination (By similarity). Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation. Belongs to the CASC3 family. Sequence=AAH60672.1; Type=Erroneous initiation; Evidence=; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA splicing, via spliceosome RNA binding protein binding nucleus spliceosomal complex cytoplasm mRNA processing regulation of translation intracellular mRNA localization RNA splicing cytoplasmic stress granule nuclear speck enzyme binding dendrite ubiquitin protein ligase binding nuclear membrane exon-exon junction complex cytoplasmic ribonucleoprotein granule identical protein binding cell projection perinuclear region of cytoplasm mRNA transport U2-type catalytic step 1 spliceosome ribonucleoprotein complex uc011yeh.1 uc011yeh.2 uc011yeh.3 
ENSMUST00000017408.14 Exosc10 ENSMUST00000017408.14 exosome component 10, transcript variant 1 (from RefSeq NM_016699.4) B1ARY9 ENSMUST00000017408.1 ENSMUST00000017408.10 ENSMUST00000017408.11 ENSMUST00000017408.12 ENSMUST00000017408.13 ENSMUST00000017408.2 ENSMUST00000017408.3 ENSMUST00000017408.4 ENSMUST00000017408.5 ENSMUST00000017408.6 ENSMUST00000017408.7 ENSMUST00000017408.8 ENSMUST00000017408.9 EXOSX_MOUSE NM_016699 P56960 Pmscl2 Q9QYS8 Q9R0B1 uc008vut.1 uc008vut.2 uc008vut.3 uc008vut.4 uc008vut.5 Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA (By similarity). Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (By similarity). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (By similarity). Plays a role in oocyte development, maturation and survival (PubMed:36923944, PubMed:32313933). Required for normal testis development and mitotic division of spermatogonia (PubMed:29118343). Plays a role in proper embryo development (PubMed:36923944, PubMed:34965385, PubMed:32313933). Required for global protein translation (By similarity). Required for cell proliferation (By similarity). Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Interacts with C1D and MPHOSPH6 (By similarity). Interacts with ALYREF/THOC4 (By similarity). Interacts with MTREX; the interaction mediates the association of MTREX with nuclear RNA exosomes (By similarity). Interacts with DHX36; this interaction occurs in a RNase-insensitive manner (By similarity). Interacts with NRDE2 (By similarity). Interacts (via C-terminus) with USP36 (via C-terminus); the interaction is facilitated by the association with RNA and promotes sumoylation of EXOSC10 (By similarity). Cytoplasm cleus cleus, nucleolus Nucleus, nucleoplasm Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form (By similarity). In oocytes, the protein is diffusely distributed in the cytoplasm, in zygotes it is found in both the cytoplasm and pronuclei and from the two-cell stage onward the protein accumulates in the nucleus, especially at the nucleolus precursor body periphery (PubMed:34965385). In metaphase blastomeres that lack structured nuclei, the protein localizes diffusely in the cytoplasm (PubMed:34965385). In spermatocytes, the protein accumulates in the nucleolus during zygotene, late pachytene and diplotene sub-stages and in the cytoplasm during metaphase I (PubMed:29118343). Expressed in ovary (at protein level) (PubMed:36923944). Expressed in testis (at protein level) (PubMed:29118343). Expressed in lung (at protein level) (PubMed:26857222). Expressed in oocytes and during all the stages of early embryogenesis (at protein level). Down-regulated by mild hypothermia (at protein level). Sumoylated by USP36; sumoylation does not significantly affect EXOSC10 nucleolar localization and association with core exosome and USP36, but regulates the nucleolar RNA exosome activity in rRNA processing by promoting binding of EXOSC10 to pre-rRNAs. Effects of sumoylation on EXOSC10 levels vary between different studies. Sumoylation of EXOSC10 is required for the modulation of EXOSC10 effects on cellular protein translation and cell proliferation. Sumoylation is promoted by mild hypothermia. Prenatal lethality (PubMed:34965385, PubMed:32313933, PubMed:29118343). Developmental arrest at the two-cell to eight-cell embryo/morula transition stages (PubMed:34965385, PubMed:32313933). Oocyte-specific knockdown does not affect the onset of puberty but results in the loss of sexual receptivity and cyclicity and leads to subfertility/infertility in female mice (PubMed:36923944, PubMed:32313933). Rapid depletion of oocytes in ovaries and disorganization of the ovarian tissue (PubMed:36923944). Dysregulation of the pathways involved in meiotic cell cycle progression, oocyte maturation, ribosome biogenesis, DNA replication and repair, mitochondria activity, transcriptional control, RNA metabolism, endomembrane and nucleocytoplasmic transport (PubMed:36923944, PubMed:32313933). Aberrant formation of the endomembrane system in the oocytes (PubMed:32313933). Defects in pre-rRNA processing in the oocytes (PubMed:32313933). Testis-specific knockdown leads to subfertility in male mice (PubMed:29118343). Abnormal testicular development and defects in spermatogenesis (PubMed:29118343). Belongs to the exosome component 10/RRP6 family. nucleotide binding 3'-5'-exoribonuclease activity nuclear exosome (RNase complex) exosome (RNase complex) nuclear-transcribed mRNA catabolic process, nonsense-mediated decay maturation of 5.8S rRNA exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nuclear-transcribed mRNA catabolic process nucleic acid binding RNA binding single-stranded RNA binding catalytic activity nuclease activity exonuclease activity exoribonuclease activity nucleus nucleolus cytoplasm cytosol nucleobase-containing compound metabolic process rRNA processing RNA processing 3'-5' exonuclease activity dosage compensation by inactivation of X chromosome hydrolase activity negative regulation of telomere maintenance via telomerase transcriptionally active chromatin cellular metabolic process nuclear mRNA surveillance CUT catabolic process nuclear polyadenylation-dependent rRNA catabolic process nuclear polyadenylation-dependent snoRNA catabolic process nuclear polyadenylation-dependent snRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent CUT catabolic process nuclear polyadenylation-dependent antisense transcript catabolic process histone mRNA catabolic process nuclear retention of unspliced pre-mRNA at the site of transcription polyadenylation-dependent snoRNA 3'-end processing regulation of telomerase RNA localization to Cajal body uc008vut.1 uc008vut.2 uc008vut.3 uc008vut.4 uc008vut.5 
ENSMUST00000017430.12 Glod4 ENSMUST00000017430.12 glyoxalase domain containing 4, transcript variant 1 (from RefSeq NM_026029.3) ENSMUST00000017430.1 ENSMUST00000017430.10 ENSMUST00000017430.11 ENSMUST00000017430.2 ENSMUST00000017430.3 ENSMUST00000017430.4 ENSMUST00000017430.5 ENSMUST00000017430.6 ENSMUST00000017430.7 ENSMUST00000017430.8 ENSMUST00000017430.9 GLOD4_MOUSE NM_026029 Q3UUS8 Q9CPV4 Q9CY26 Q9D9F5 uc007kfl.1 uc007kfl.2 uc007kfl.3 uc007kfl.4 Interacts with NUDT9. Mitochondrion Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9CPV4-1; Sequence=Displayed; Name=2; IsoId=Q9CPV4-2; Sequence=VSP_023650, VSP_023651; Name=3; IsoId=Q9CPV4-3; Sequence=VSP_023649; Belongs to the glyoxalase I family. mitochondrion uc007kfl.1 uc007kfl.2 uc007kfl.3 uc007kfl.4 
ENSMUST00000017443.14 Dnttip1 ENSMUST00000017443.14 deoxynucleotidyltransferase, terminal, interacting protein 1 (from RefSeq NM_133763.1) ENSMUST00000017443.1 ENSMUST00000017443.10 ENSMUST00000017443.11 ENSMUST00000017443.12 ENSMUST00000017443.13 ENSMUST00000017443.2 ENSMUST00000017443.3 ENSMUST00000017443.4 ENSMUST00000017443.5 ENSMUST00000017443.6 ENSMUST00000017443.7 ENSMUST00000017443.8 ENSMUST00000017443.9 NM_133763 Q99LB0 TDIF1_MOUSE Tdif1 uc008nvx.1 uc008nvx.2 uc008nvx.3 uc008nvx.4 Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA. Monomer and homodimer (By similarity). A minor proportion may form homotrimers (By similarity). Interacts with ZNF541 (PubMed:18849567). Interacts with the terminal deoxynucleotidyltransferase DNTT (By similarity). Interacts with TRERF1 (By similarity). Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and MIDEAS; this complex assembles into a tetramer that contains four copies of each protein chain (By similarity). Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2 (By similarity). Identified in a complex with KCTD19, HDAC1, HDAC2 and ZNF541 (PubMed:34075040, PubMed:35341968). Nucleus The N-terminal domain mediates dimerization. The C-terminal domain mediates interaction with DNA and nucleosomes. It contains a HTH motif that mediates recognition of the consensus sequence. histone deacetylase complex DNA binding nucleus nucleoplasm nucleolus enzyme activator activity nucleosome binding protein homodimerization activity positive regulation of catalytic activity uc008nvx.1 uc008nvx.2 uc008nvx.3 uc008nvx.4 
ENSMUST00000017453.12 Cd300lg ENSMUST00000017453.12 CD300 molecule like family member G, transcript variant 4 (from RefSeq NM_027987.3) A2A503 CLM9_MOUSE Clm9 D11Ertd736e ENSMUST00000017453.1 ENSMUST00000017453.10 ENSMUST00000017453.11 ENSMUST00000017453.2 ENSMUST00000017453.3 ENSMUST00000017453.4 ENSMUST00000017453.5 ENSMUST00000017453.6 ENSMUST00000017453.7 ENSMUST00000017453.8 ENSMUST00000017453.9 NM_027987 Q1ERP8 Q1ERP9 Q1ERQ0 Q3UU12 Q6SJP9 Q9D7B8 uc007lqg.1 uc007lqg.2 uc007lqg.3 uc007lqg.4 Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte. Apical cell membrane ; Single-pass type I membrane protein Basolateral cell membrane ; Single-pass type I membrane protein Endosome, multivesicular body membrane ; Single-pass type I membrane protein Note=Exclusively localized on capillary endothelium. Transcytoses across the cytoplasm in the capillary endothelium. Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=isoform C, CD300LG-beta; IsoId=Q1ERP8-1; Sequence=Displayed; Name=2; Synonyms=isoform B, CD300LG-gamma; IsoId=Q1ERP8-2; Sequence=VSP_028413; Name=3; Synonyms=isoform A, CD300LG-delta; IsoId=Q1ERP8-3; Sequence=VSP_028415; Name=4; IsoId=Q1ERP8-4; Sequence=VSP_028413, VSP_028416, VSP_028417; Name=5; Synonyms=isoform D, CD300LG-alpha; IsoId=Q1ERP8-5; Sequence=VSP_028414; Expressed in monocyte cell lines. Expressed in certain types of endothelial and myeloid lineage cells. Expressed in mesenteric lymph nodes (LNs), spleen, thymus, lung, heart and kidney. Expressed in high endothelial venules (HEVs) in peripheral and mesenteric LNs (at protein level). Highly expressed in heart. Slightly expressed in spleen and thymus. Isoform 5 is expressed preferentially in heart. Isoform 1 is expressed predominantly in kidney and liver. Ig-like V-type domain mediates binding to lymphocyte. O-glycosylated with sialylated oligosaccharides. Belongs to the CD300 family. Sequence=CAM23248.1; Type=Erroneous gene model prediction; Evidence=; IgM binding immune system process immunoglobulin transcytosis in epithelial cells endosome plasma membrane membrane integral component of membrane basolateral plasma membrane apical plasma membrane multivesicular body membrane uc007lqg.1 uc007lqg.2 uc007lqg.3 uc007lqg.4 
ENSMUST00000017454.8 Spint4 ENSMUST00000017454.8 serine protease inhibitor, Kunitz type 4 (from RefSeq NM_030058.2) ENSMUST00000017454.1 ENSMUST00000017454.2 ENSMUST00000017454.3 ENSMUST00000017454.4 ENSMUST00000017454.5 ENSMUST00000017454.6 ENSMUST00000017454.7 NM_030058 Q9D263 SPIT4_MOUSE uc008nvr.1 uc008nvr.2 uc008nvr.3 Secreted Highly expressed in the epididymis, in the epithelial cells of the distal caput and early corpus. Expression starts at the time of epididymal maturation. By androgens. Expression diminishes after 1-3 days and disappears 7 days postgonadectomy. molecular_function serine-type endopeptidase inhibitor activity cellular_component extracellular region biological_process negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc008nvr.1 uc008nvr.2 uc008nvr.3 
ENSMUST00000017458.11 Mpp2 ENSMUST00000017458.11 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2), transcript variant 2 (from RefSeq NM_016695.5) B1AQF8 Dlgh2 ENSMUST00000017458.1 ENSMUST00000017458.10 ENSMUST00000017458.2 ENSMUST00000017458.3 ENSMUST00000017458.4 ENSMUST00000017458.5 ENSMUST00000017458.6 ENSMUST00000017458.7 ENSMUST00000017458.8 ENSMUST00000017458.9 MPP2_MOUSE Mpp2 NM_016695 Q3T9W1 Q3TT52 Q3URK8 Q9WV34 uc007lql.1 uc007lql.2 uc007lql.3 uc007lql.4 Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2- containing channel function and long-term potentiation expression (PubMed:26880549). Seems to negatively regulate SRC function in epithelial cells (By similarity). Can homomultimerise. Interacts with CACNG2. Interacts (via the SH3-Guanylate kinase-like sub-module) with DLG4/PSD95 and DLGAP1/GKAP. Interacts (via the PDZ domain) with CADM1 (via C-terminus) (By similarity). Interacts with KCNN2/SK2 (via N-terminal domain) (PubMed:26880549). Interacts with SRC (By similarity). Cell projection, dendrite Postsynaptic density Cytoplasm, cytoskeleton Membrane Note=Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WV34-1; Sequence=Displayed; Name=2; IsoId=Q9WV34-2; Sequence=VSP_022952; Expressed in pyramidal neurons of CA1 region of the hippocampus. Phosphorylated by SRC. Belongs to the MAGUK family. protein binding cytoplasm cytoskeleton plasma membrane postsynaptic density membrane cell junction PDZ domain binding dendrite dendrite membrane dendritic spine membrane cell projection dendritic spine dendritic shaft ion channel binding synapse postsynaptic membrane protein homooligomerization excitatory postsynaptic potential long-term synaptic potentiation structural constituent of postsynaptic density glutamatergic synapse anchored component of postsynaptic density membrane maintenance of postsynaptic density structure uc007lql.1 uc007lql.2 uc007lql.3 uc007lql.4 
ENSMUST00000017460.6 Ppy ENSMUST00000017460.6 pancreatic polypeptide (from RefSeq NM_008918.2) ENSMUST00000017460.1 ENSMUST00000017460.2 ENSMUST00000017460.3 ENSMUST00000017460.4 ENSMUST00000017460.5 NM_008918 Ppy Q496X5 Q496X5_MOUSE uc007lqm.1 uc007lqm.2 uc007lqm.3 Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2. Secreted Belongs to the NPY family. G-protein coupled receptor binding hormone activity extracellular region signal transduction uc007lqm.1 uc007lqm.2 uc007lqm.3 
ENSMUST00000017488.5 Vtn ENSMUST00000017488.5 vitronectin (from RefSeq NM_011707.2) ENSMUST00000017488.1 ENSMUST00000017488.2 ENSMUST00000017488.3 ENSMUST00000017488.4 NM_011707 P29788 Q5SYG4 Q8VII4 Q91X32 Q9D080 VTNC_MOUSE uc007kjk.1 uc007kjk.2 uc007kjk.3 uc007kjk.4 Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Interacts with SERPINE1/PAI1, insulin and C1QBP. Secreted, extracellular space. Plasma. The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin (By similarity). Sulfated on tyrosine residues. N- and O-glycosylated. It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both. scavenger receptor activity integrin binding extracellular matrix structural constituent collagen binding extracellular region basement membrane extracellular space cytoplasm endoplasmic reticulum Golgi lumen endocytosis immune response cell adhesion cell-matrix adhesion heparin binding cell proliferation positive regulation of cell-substrate adhesion negative regulation of endopeptidase activity positive regulation of smooth muscle cell migration cell migration extracellular matrix organization polysaccharide binding extracellular matrix positive regulation of protein binding cell adhesion mediated by integrin endodermal cell differentiation identical protein binding intracellular membrane-bounded organelle rough endoplasmic reticulum lumen positive regulation of receptor-mediated endocytosis oligodendrocyte differentiation positive regulation of peptidyl-tyrosine phosphorylation extracellular matrix binding protein polymerization smooth muscle cell-matrix adhesion liver regeneration uc007kjk.1 uc007kjk.2 uc007kjk.3 uc007kjk.4 
ENSMUST00000017530.4 Traf4 ENSMUST00000017530.4 TNF receptor associated factor 4 (from RefSeq NM_009423.4) Cart1 ENSMUST00000017530.1 ENSMUST00000017530.2 ENSMUST00000017530.3 NM_009423 Q61382 Q8BHD9 TRAF4_MOUSE uc007kif.1 uc007kif.2 uc007kif.3 uc007kif.4 Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'- linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (By similarity). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta- catenin signaling pathway (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein degradation; proteasomal ubiquitin-dependent pathway. Homotrimer. Interacts with LTBR/TNFRSF3, NGFR/TNFRSF16, RPS6KB1 and TGFB1I1. Interacts with SMURF1. Interacts (via TRAF domain) with MAP3K4 (via kinase domain). Interacts with NCF1, TICAM1, IRAK1 and TRAF6, and is probably part of a complex containing TRAF4, NCF1, TICAM1, IRAK1 and TRAF6. Interacts (via MATH domain) with GP6 and GP1BB. Interacts with EGFR (via C-terminal region); this interaction promotes the formation of EGFR asymmetric dimers. Interacts with PKM; this interaction promotes PKM kinase activity. Cytoplasm Nucleus Cytoplasm, perinuclear region Cell junction, tight junction Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Predominantly expressed in brain. Preferentially expressed by postmitotic undifferentiated neurons in developing central (CNS) and peripheral (PNS) nervous system, and in nervous tissues of sensory organs. In the embryo, protein expression was shown in brain, thymus, salivary glands and intestine. In the adult, protein expression is restricted to the brain (hippocampus and olfactory bulb). Strongly expressed throughout embryogenesis with a maximum from 8.5 to 13.5 dpc. The coiled coil domain mediates homo- and hetero- oligomerization. The MATH/TRAF domain binds to receptor cytoplasmic domains. Polyubiquitinated, leading to its proteasomal degradation (By similarity). Ubiquitinated at Lys-263 by the SCF(FBXL2) complex, leading to its degradation by the proteasome (PubMed:23542741). Mice exhibit considerable phenotypic variability, depending in part on the strain. In one strain pups are born at the expected Mendelian frequency, while in another strain up to one third die during embryogenesis. Mutants that reach adulthood are fertile, but have on average three pups per litter instead of ten in wild-type. Mutants have an apparently normal immune response, with no defects in the development of T and B-lymphocytes, granulocytes, macrophages and dendritic cells. Mutants have respiratory problems, due to developmental defects of the trachea, stem bronchi and rib cage. They exhibit severe skeletal alterations at the level of the spinal column, including scoliosis and kyphosis, and have curly tails. Many also display neural tube closure defects. Belongs to the TNF receptor-associated factor family. B subfamily. tumor necrosis factor receptor binding nucleus cytoplasm cytoskeleton plasma membrane bicellular tight junction apoptotic process signal transduction activation of NF-kappaB-inducing kinase activity multicellular organism development respiratory gaseous exchange zinc ion binding membrane protein kinase binding cell junction respiratory tube development ubiquitin protein ligase binding thioesterase binding macromolecular complex identical protein binding regulation of apoptotic process positive regulation of protein kinase activity positive regulation of JNK cascade metal ion binding perinuclear region of cytoplasm WW domain binding positive regulation of protein homodimerization activity uc007kif.1 uc007kif.2 uc007kif.3 uc007kif.4 
ENSMUST00000017534.15 Aldoc ENSMUST00000017534.15 aldolase C, fructose-bisphosphate, transcript variant 2 (from RefSeq NM_001303423.1) ALDOC_MOUSE Aldo3 ENSMUST00000017534.1 ENSMUST00000017534.10 ENSMUST00000017534.11 ENSMUST00000017534.12 ENSMUST00000017534.13 ENSMUST00000017534.14 ENSMUST00000017534.2 ENSMUST00000017534.3 ENSMUST00000017534.4 ENSMUST00000017534.5 ENSMUST00000017534.6 ENSMUST00000017534.7 ENSMUST00000017534.8 ENSMUST00000017534.9 NM_001303423 P05063 Q64011 Q8CA91 Q99K96 Q9DBA4 Q9JK32 Scrg2 uc007kiw.1 uc007kiw.2 uc007kiw.3 uc007kiw.4 uc007kiw.5 This gene encodes a member of the aldolase family of enzymes that is mainly expressed in neuronal tissues. The encoded protein is an enzyme of the glycolysis pathway, and catalyzes the conversion of fructose-1,6-bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]. Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3- phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729, ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=4.1.2.13; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 4/4. Homotetramer. Interacts with ATP6V1E1 (By similarity). Expressed exclusively in Purkinje cells in bands running from anterior to posterior across most of the cerebellum. Expressed at higher levels in the brains of BSE-infected animals. Expression begins in the first week of postnatal life. In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain. Belongs to the class I fructose-bisphosphate aldolase family. catalytic activity fructose-bisphosphate aldolase activity cytoplasm mitochondrion cytosol glycolytic process apoptotic process aging cytoskeletal protein binding lyase activity fructose 1,6-bisphosphate metabolic process axon epithelial cell differentiation protein homotetramerization protein heterotetramerization postsynaptic cytosol uc007kiw.1 uc007kiw.2 uc007kiw.3 uc007kiw.4 uc007kiw.5 
ENSMUST00000017544.9 Stac2 ENSMUST00000017544.9 SH3 and cysteine rich domain 2 (from RefSeq NM_146028.4) ENSMUST00000017544.1 ENSMUST00000017544.2 ENSMUST00000017544.3 ENSMUST00000017544.4 ENSMUST00000017544.5 ENSMUST00000017544.6 ENSMUST00000017544.7 ENSMUST00000017544.8 NM_146028 Q8BV93 Q8K2U4 Q8R1B0 STAC2_MOUSE uc007lfl.1 uc007lfl.2 uc007lfl.3 Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity (PubMed:29467163). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:25548159, PubMed:29363593). Interacts (via SH3 domains) with CACNA1S (PubMed:29467163). Interacts (via SH3 domains) with CACNA1C (PubMed:29363593). Has much lower affinity for CACNA1C than for CACNA1S (By similarity). Cytoplasm, cytosol ll membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side Note=Colocalizes with CACNA1C at the plasma membrane of transfected cells. Detected in cerebellum, forebrain and midbrain, and in the eye. Up-regulated in cerebral ischemia. skeletal muscle contraction molecular_function cytoplasm cytosol plasma membrane membrane extrinsic component of cytoplasmic side of plasma membrane intracellular signal transduction sarcolemma metal ion binding positive regulation of voltage-gated calcium channel activity positive regulation of protein localization to plasma membrane uc007lfl.1 uc007lfl.2 uc007lfl.3 
ENSMUST00000017548.7 Rpl19 ENSMUST00000017548.7 ribosomal protein L19, transcript variant 1 (from RefSeq NM_009078.2) ENSMUST00000017548.1 ENSMUST00000017548.2 ENSMUST00000017548.3 ENSMUST00000017548.4 ENSMUST00000017548.5 ENSMUST00000017548.6 NM_009078 Q5I0T8 Q5I0T8_MOUSE Rpl19 uc007lfj.1 uc007lfj.2 uc007lfj.3 uc007lfj.4 Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL19 family. cytoplasmic translation RNA binding structural constituent of ribosome ribosome translation cytosolic large ribosomal subunit polysomal ribosome uc007lfj.1 uc007lfj.2 uc007lfj.3 uc007lfj.4 
ENSMUST00000017549.13 Nek8 ENSMUST00000017549.13 NIMA (never in mitosis gene a)-related expressed kinase 8 (from RefSeq NM_080849.3) ENSMUST00000017549.1 ENSMUST00000017549.10 ENSMUST00000017549.11 ENSMUST00000017549.12 ENSMUST00000017549.2 ENSMUST00000017549.3 ENSMUST00000017549.4 ENSMUST00000017549.5 ENSMUST00000017549.6 ENSMUST00000017549.7 ENSMUST00000017549.8 ENSMUST00000017549.9 Jck NEK8_MOUSE NM_080849 Q3U498 Q91ZR4 Q9D685 uc007kih.1 uc007kih.2 uc007kih.3 uc007kih.4 This gene encodes a NIMA-related kinase. Members of this serine/threonine protein kinase family are structurally-related to NIMA (never in mitosis, gene A) which controls mitotic signaling in Aspergillus nidulans. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070457.1, AF407579.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with PKD2; may regulate PKD2 targeting to the cilium (PubMed:18235101). Component of a complex containing at least ANKS6, INVS, NEK8 and NPHP3 (By similarity). ANKS6 may organize complex assembly by linking INVS and NPHP3 to NEK8 and INVS may target the complex to the proximal ciliary axoneme (By similarity). Interacts with ANKS3 (PubMed:25671767). Q91ZR4; O89019: Invs; NbExp=2; IntAct=EBI-4282339, EBI-4281337; Cytoplasm Cytoplasm, cytoskeleton Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells. Kidney, liver, and testis. Note=Defects in Nek8 are the cause of autosomal recessive juvenile polycystic kidney disease (ARJPKD). Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm centrosome cytoskeleton cilium protein phosphorylation chromosome segregation determination of left/right symmetry heart development animal organ morphogenesis kinase activity phosphorylation transferase activity regulation of hippo signaling cell projection metal ion binding ciliary inversin compartment ciliary base uc007kih.1 uc007kih.2 uc007kih.3 uc007kih.4 
ENSMUST00000017552.13 Cacnb1 ENSMUST00000017552.13 calcium channel, voltage-dependent, beta 1 subunit, transcript variant 2 (from RefSeq NM_145121.4) A2A543 A2A543_MOUSE Cacnb1 ENSMUST00000017552.1 ENSMUST00000017552.10 ENSMUST00000017552.11 ENSMUST00000017552.12 ENSMUST00000017552.2 ENSMUST00000017552.3 ENSMUST00000017552.4 ENSMUST00000017552.5 ENSMUST00000017552.6 ENSMUST00000017552.7 ENSMUST00000017552.8 ENSMUST00000017552.9 NM_145121 uc007lff.1 uc007lff.2 uc007lff.3 uc007lff.4 uc007lff.5 Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side Membrane ; Peripheral membrane protein Belongs to the calcium channel beta subunit family. voltage-gated calcium channel activity voltage-gated calcium channel complex calcium ion transmembrane transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel cellular response to beta-amyloid uc007lff.1 uc007lff.2 uc007lff.3 uc007lff.4 uc007lff.5 
ENSMUST00000017561.15 Plxdc1 ENSMUST00000017561.15 plexin domain containing 1, transcript variant 2 (from RefSeq NM_028199.3) A2A537 A2A538 ENSMUST00000017561.1 ENSMUST00000017561.10 ENSMUST00000017561.11 ENSMUST00000017561.12 ENSMUST00000017561.13 ENSMUST00000017561.14 ENSMUST00000017561.2 ENSMUST00000017561.3 ENSMUST00000017561.4 ENSMUST00000017561.5 ENSMUST00000017561.6 ENSMUST00000017561.7 ENSMUST00000017561.8 ENSMUST00000017561.9 NM_028199 PLDX1_MOUSE Q29R73 Q8BM20 Q91ZV7 Q9CWV5 Tem7 uc007lfc.1 uc007lfc.2 uc007lfc.3 uc007lfc.4 Plays a critical role in endothelial cell capillary morphogenesis. Interacts with NID1. May interact with CTTN. Q91ZV7; P08460: Nid1; Xeno; NbExp=2; IntAct=EBI-8280807, EBI-8280787; Cell membrane ; Single-pass type I membrane protein Cell junction, tight junction Secreted Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91ZV7-1; Sequence=Displayed; Name=2; IsoId=Q91ZV7-2; Sequence=VSP_017975; Detected in brain. Highly expressed in Purkinje cells of the cerebellum. Expression increases in endothelial cells undergoing capillary morphogenesis. Belongs to the plexin family. angiogenesis protein binding cytoplasm plasma membrane bicellular tight junction membrane integral component of membrane spinal cord development cell junction dendrite neuronal cell body receptor complex uc007lfc.1 uc007lfc.2 uc007lfc.3 uc007lfc.4 
ENSMUST00000017572.14 Psmd11 ENSMUST00000017572.14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 (from RefSeq NM_178616.3) ENSMUST00000017572.1 ENSMUST00000017572.10 ENSMUST00000017572.11 ENSMUST00000017572.12 ENSMUST00000017572.13 ENSMUST00000017572.2 ENSMUST00000017572.3 ENSMUST00000017572.4 ENSMUST00000017572.5 ENSMUST00000017572.6 ENSMUST00000017572.7 ENSMUST00000017572.8 ENSMUST00000017572.9 NM_178616 PSD11_MOUSE Q8BG32 uc007kmf.1 uc007kmf.2 uc007kmf.3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD11, a base containing 6 ATPases and few additional components. Belongs to the proteasome subunit S9 family. proteasome complex structural molecule activity protein binding proteasome regulatory particle ubiquitin-dependent protein catabolic process proteasome regulatory particle, lid subcomplex proteasome accessory complex proteasome assembly stem cell differentiation uc007kmf.1 uc007kmf.2 uc007kmf.3 
ENSMUST00000017590.9 C1qtnf1 ENSMUST00000017590.9 C1q and tumor necrosis factor related protein 1, transcript variant 3 (from RefSeq NM_001204130.1) C1QT1_MOUSE ENSMUST00000017590.1 ENSMUST00000017590.2 ENSMUST00000017590.3 ENSMUST00000017590.4 ENSMUST00000017590.5 ENSMUST00000017590.6 ENSMUST00000017590.7 ENSMUST00000017590.8 NM_001204130 Q80VI9 Q9QXP7 Zsig37 uc007mpg.1 uc007mpg.2 uc007mpg.3 uc007mpg.4 Secreted protein binding collagen binding extracellular region collagen trimer extracellular space integral component of plasma membrane positive regulation of cytosolic calcium ion concentration negative regulation of platelet activation positive regulation of gene expression regulation of glucose metabolic process identical protein binding positive regulation of MAPK cascade positive regulation of protein kinase B signaling negative regulation of platelet aggregation positive regulation of aldosterone secretion uc007mpg.1 uc007mpg.2 uc007mpg.3 uc007mpg.4 
ENSMUST00000017597.5 Pipox ENSMUST00000017597.5 pipecolic acid oxidase (from RefSeq NM_008952.2) ENSMUST00000017597.1 ENSMUST00000017597.2 ENSMUST00000017597.3 ENSMUST00000017597.4 NM_008952 O55223 Pso Q9D826 SOX_MOUSE uc007khm.1 uc007khm.2 uc007khm.3 uc007khm.4 Metabolizes sarcosine, L-pipecolic acid and L-proline. Reaction=H2O + O2 + sarcosine = formaldehyde + glycine + H2O2; Xref=Rhea:RHEA:13313, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:16842, ChEBI:CHEBI:57305, ChEBI:CHEBI:57433; EC=1.5.3.1; Reaction=L-pipecolate + O2 = H(+) + H2O2 + L-1-piperideine-6- carboxylate; Xref=Rhea:RHEA:11992, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:58769, ChEBI:CHEBI:61185; EC=1.5.3.7; Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.; Monomer. Peroxisome Kidney and liver. Belongs to the MSOX/MTOX family. peroxisome sarcosine oxidase activity oxidoreductase activity L-lysine catabolic process to acetyl-CoA via L-pipecolate tetrahydrofolate metabolic process L-pipecolate oxidase activity oxidation-reduction process uc007khm.1 uc007khm.2 uc007khm.3 uc007khm.4 
ENSMUST00000017604.10 Cyba ENSMUST00000017604.10 cytochrome b-245, alpha polypeptide, transcript variant 1 (from RefSeq NM_007806.3) CY24A_MOUSE Cyba ENSMUST00000017604.1 ENSMUST00000017604.2 ENSMUST00000017604.3 ENSMUST00000017604.4 ENSMUST00000017604.5 ENSMUST00000017604.6 ENSMUST00000017604.7 ENSMUST00000017604.8 ENSMUST00000017604.9 NM_007806 Q3U820 Q61462 Q9CWB9 Q9D2W2 uc009nsp.1 uc009nsp.2 uc009nsp.3 uc009nsp.4 Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain). Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX4. Interacts with calprotectin (S100A8/9) (By similarity). Interacts with SH3PXD2A (PubMed:19755709). Interacts with GBP7 (PubMed:21551061). Interacts with NOXO1 (By similarity). Forms a heterodimer with NOX3 and is essential for activity and cell membrane localization of NOX3 (By similarity). Q61462; Q61093: Cybb; NbExp=4; IntAct=EBI-15795776, EBI-6654585; Cell membrane Note=As unassembled monomer may localize to the endoplasmic reticulum. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61462-1; Sequence=Displayed; Name=2; IsoId=Q61462-2; Sequence=VSP_001248; The strongest level of expression is found in kidney, peritoneal neutrophils and peritoneal macrophages, and a lower level in spleen and small intestine. Very low level of expression can be noted in brain, liver, testis, and heart. The heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both, and it is possible that more than one heme is present per cytochrome b-245. Phosphorylation at Thr-147 enhances NADPH oxidase activity by promoting p47phox binding. Ubiquitinated at Lys-149 likely by RNF145. Mice show defects in invadopodia biogenesis (PubMed:19755709). Mutants have a very sever defect in controlling bacterial replication (PubMed:28351984). Mice show spontaneous trunk curland head bobbing and fail to exhibit contact-rghting reflex (PubMed:28351984). Belongs to the p22phox family. response to hypoxia stress fiber positive regulation of endothelial cell proliferation negative regulation of glomerular filtration by angiotensin protein binding nucleus cytoplasm mitochondrion endosome Golgi apparatus plasma membrane focal adhesion superoxide metabolic process inflammatory response electron carrier activity response to activity smooth muscle hypertrophy membrane superoxide-generating NADPH oxidase activity apical plasma membrane oxidoreductase activity cytochrome complex assembly SH3 domain binding heme binding electron transport chain positive regulation of cell growth dendrite response to nutrient levels positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of superoxide anion generation positive regulation of NAD(P)H oxidase activity positive regulation of toll-like receptor 2 signaling pathway response to drug superoxide anion generation NADPH oxidase complex neuronal cell body innate immune response respiratory burst positive regulation of blood pressure metal ion binding protein heterodimerization activity positive regulation of smooth muscle cell proliferation hydrogen peroxide biosynthetic process positive regulation of phagocytosis regulation of release of sequestered calcium ion into cytosol oxidation-reduction process positive regulation of mucus secretion response to interleukin-1 cellular response to amino acid stimulus cellular response to mechanical stimulus cellular response to organic substance cellular response to glucose stimulus cellular response to tumor necrosis factor cellular response to organic cyclic compound cellular response to gamma radiation reactive oxygen species metabolic process perinuclear endoplasmic reticulum positive regulation of defense response to bacterium positive regulation of reactive oxygen species biosynthetic process response to aldosterone cellular response to angiotensin cellular response to L-glutamine uc009nsp.1 uc009nsp.2 uc009nsp.3 uc009nsp.4 
ENSMUST00000017610.11 Timp2 ENSMUST00000017610.11 tissue inhibitor of metalloproteinase 2 (from RefSeq NM_011594.3) ENSMUST00000017610.1 ENSMUST00000017610.10 ENSMUST00000017610.2 ENSMUST00000017610.3 ENSMUST00000017610.4 ENSMUST00000017610.5 ENSMUST00000017610.6 ENSMUST00000017610.7 ENSMUST00000017610.8 ENSMUST00000017610.9 NM_011594 Q6PI17 Q6PI17_MOUSE Timp2 uc007mow.1 uc007mow.2 uc007mow.3 uc007mow.4 Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity. Belongs to the protease inhibitor I35 (TIMP) family. protease binding integrin binding extracellular region extracellular space central nervous system development aging metalloendopeptidase inhibitor activity zinc ion binding negative regulation of cell proliferation cell surface negative regulation of endopeptidase activity peptidase inhibitor activity growth cone regulation of Rap protein signal transduction response to cytokine response to drug neuron projection neuronal cell body positive regulation of MAPK cascade positive regulation of neuron differentiation positive regulation of adenylate cyclase activity negative regulation of proteolysis negative regulation of mitotic cell cycle negative regulation of Ras protein signal transduction negative regulation of metallopeptidase activity uc007mow.1 uc007mow.2 uc007mow.3 uc007mow.4 
ENSMUST00000017620.10 Cant1 ENSMUST00000017620.10 Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > IDP >> UTP > CDP = GTP = ITP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis. (from UniProt Q8VCF1) AK085059 B1AQJ8 CANT1_MOUSE ENSMUST00000017620.1 ENSMUST00000017620.2 ENSMUST00000017620.3 ENSMUST00000017620.4 ENSMUST00000017620.5 ENSMUST00000017620.6 ENSMUST00000017620.7 ENSMUST00000017620.8 ENSMUST00000017620.9 Q8C3R8 Q8C4T6 Q8VCF1 Q9D3F2 Q9D9R1 uc007mpe.1 uc007mpe.2 Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > IDP >> UTP > CDP = GTP = ITP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis. Reaction=a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'- phosphate + H(+) + phosphate; Xref=Rhea:RHEA:36799, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:58043; EC=3.6.1.6; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Monomer. Homodimer; dimerization is Ca(2+)-dependent. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Note=Processed form: Secreted. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VCF1-1; Sequence=Displayed; Name=2; IsoId=Q8VCF1-2; Sequence=VSP_013763, VSP_013764; Name=3; IsoId=Q8VCF1-3; Sequence=VSP_013762; Belongs to the apyrase family. Sequence=BAB31014.1; Type=Frameshift; Evidence=; Sequence=BAC39351.1; Type=Frameshift; Evidence=; guanosine-diphosphatase activity calcium ion binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus ribonucleoside diphosphate catabolic process membrane integral component of membrane hydrolase activity nucleoside-diphosphatase activity proteoglycan biosynthetic process Golgi cisterna membrane protein homodimerization activity adenosine-diphosphatase activity uridine-diphosphatase activity metal ion binding uc007mpe.1 uc007mpe.2 
ENSMUST00000017622.12 Zc3h18 ENSMUST00000017622.12 zinc finger CCCH-type containing 18, transcript variant 1 (from RefSeq NM_001029993.1) ENSMUST00000017622.1 ENSMUST00000017622.10 ENSMUST00000017622.11 ENSMUST00000017622.2 ENSMUST00000017622.3 ENSMUST00000017622.4 ENSMUST00000017622.5 ENSMUST00000017622.6 ENSMUST00000017622.7 ENSMUST00000017622.8 ENSMUST00000017622.9 G3X8T2 G3X8T2_MOUSE NM_001029993 Zc3h18 uc009nsm.1 uc009nsm.2 uc009nsm.3 uc009nsm.4 nuclear speck uc009nsm.1 uc009nsm.2 uc009nsm.3 uc009nsm.4 
ENSMUST00000017629.12 Top2b ENSMUST00000017629.12 topoisomerase (DNA) II beta (from RefSeq NM_009409.3) ENSMUST00000017629.1 ENSMUST00000017629.10 ENSMUST00000017629.11 ENSMUST00000017629.2 ENSMUST00000017629.3 ENSMUST00000017629.4 ENSMUST00000017629.5 ENSMUST00000017629.6 ENSMUST00000017629.7 ENSMUST00000017629.8 ENSMUST00000017629.9 NM_009409 Q64511 Q7TQG4 TOP2B_MOUSE uc007shc.1 uc007shc.2 uc007shc.3 Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). Homodimer (By similarity). Interacts with KIAA1210 (PubMed:28203736). Interacts with PLSCR1 (By similarity). Q64511; Q9WVE0: Aicda; NbExp=3; IntAct=EBI-2325586, EBI-3835567; Nucleus, nucleolus Nucleus, nucleoplasm Nucleus Knockout animals have B-cell developmental defects affecting multiple stages of development likely due to transcriptional defects. These mutant mice have altered splenic follicle structure with reduce marginal zone and follicular B-cell zones; immunophenotyping show decreased B- cells at all stages of development. Mutant mice fail to mount an antibody response to vaccination and B-cells fail to proliferate in response to stimulation, indicating deficits in B-cell function. Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils. Belongs to the type II topoisomerase family. nucleotide binding resolution of meiotic recombination intermediates sister chromatid segregation neuron migration DNA binding chromatin binding DNA topoisomerase activity DNA topoisomerase type II (ATP-hydrolyzing) activity protein kinase C binding protein binding ATP binding nucleus nucleoplasm nucleolus cytosol DNA metabolic process DNA topological change axonogenesis cell aging protein C-terminus binding isomerase activity viral integration complex enzyme binding forebrain development histone deacetylase binding ribonucleoprotein complex binding mitotic DNA integrity checkpoint positive regulation of single stranded viral RNA replication via double stranded DNA intermediate metal ion binding protein heterodimerization activity cellular response to hydrogen peroxide cellular response to ATP ribonucleoprotein complex positive regulation of double-strand break repair via nonhomologous end joining heterochromatin chromosome uc007shc.1 uc007shc.2 uc007shc.3 
ENSMUST00000017637.13 Igfbp4 ENSMUST00000017637.13 insulin-like growth factor binding protein 4 (from RefSeq NM_010517.4) ENSMUST00000017637.1 ENSMUST00000017637.10 ENSMUST00000017637.11 ENSMUST00000017637.12 ENSMUST00000017637.2 ENSMUST00000017637.3 ENSMUST00000017637.4 ENSMUST00000017637.5 ENSMUST00000017637.6 ENSMUST00000017637.7 ENSMUST00000017637.8 ENSMUST00000017637.9 IBP4_MOUSE Igfbp-4 NM_010517 O35666 P47879 Q3TMV0 uc007lie.1 uc007lie.2 uc007lie.3 uc007lie.4 IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Binds IGF2 more than IGF1. P47879; Q61091: Fzd8; NbExp=3; IntAct=EBI-15706768, EBI-6171689; P47879; O75581: LRP6; Xeno; NbExp=4; IntAct=EBI-15706768, EBI-910915; Secreted. regulation of cell growth protein binding insulin-like growth factor binding extracellular region extracellular space inflammatory response regulation of glucose metabolic process growth factor binding insulin-like growth factor I binding insulin-like growth factor II binding regulation of growth positive regulation of MAPK cascade regulation of insulin-like growth factor receptor signaling pathway positive regulation of insulin-like growth factor receptor signaling pathway type B pancreatic cell proliferation uc007lie.1 uc007lie.2 uc007lie.3 uc007lie.4 
ENSMUST00000017692.15 Suz12 ENSMUST00000017692.15 SUZ12 polycomb repressive complex 2 subunit, transcript variant 1 (from RefSeq NM_199196.2) B1AQE5 D11Ertd530e ENSMUST00000017692.1 ENSMUST00000017692.10 ENSMUST00000017692.11 ENSMUST00000017692.12 ENSMUST00000017692.13 ENSMUST00000017692.14 ENSMUST00000017692.2 ENSMUST00000017692.3 ENSMUST00000017692.4 ENSMUST00000017692.5 ENSMUST00000017692.6 ENSMUST00000017692.7 ENSMUST00000017692.8 ENSMUST00000017692.9 Kiaa0160 NM_199196 Q80U70 Q80Y10 Q99L07 SUZ12_MOUSE uc007klc.1 uc007klc.2 This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]. Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED- EZH2 complex include HOXA7, HOXB6 and HOXC8. Component of the PRC2 complex, which consists of the core subunits EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:19026780, PubMed:20144788). Within the complex, interacts (via C2H2 zinc finger domain) with JARID2 and EPOP; JARID2 and EPOP compete for SUZ12 binding (By similarity). Also interacts with AEBP2 and PHF19 (By similarity). Forms a monomeric PRC2.2 (class 2) complex consisting of at least SUZ12, RBBP4, AEBP2 and JARID2 (By similarity). Forms a dimeric PRC2.1 (class 1, PRC-PCL) complex consisting of at least SUZ12, RBBP4, and PHF19 or MTF2; PHF19 and MTF2 stabilize the dimeric structure which enhances PRC2 interaction with chromatin (By similarity). The minimum components required for methyltransferase activity of the PRC2/EZH2 complex are EED, EZH2 and SUZ12 (By similarity). The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with WDR77 (PubMed:16712789). Interacts with histone H1. Interacts with CDYL (By similarity). Interacts with BMAL1 (PubMed:23970558). Interacts with EZHIP (via C-terminal region) (By similarity). Interacts with ARMC12 (By similarity). Q80U70; Q7TNS8: Epop; NbExp=2; IntAct=EBI-2526494, EBI-16024836; Q80U70; Q61188: Ezh2; NbExp=10; IntAct=EBI-2526494, EBI-904311; Q80U70; Q6AXH7: Ezh2; NbExp=3; IntAct=EBI-2526494, EBI-6876582; Q80U70; Q62315: Jarid2; NbExp=13; IntAct=EBI-2526494, EBI-493592; Q80U70; Q3UXZ9: Kdm5a; NbExp=2; IntAct=EBI-2526494, EBI-2531441; Nucleus Chromosome Note=Localizes to the inactive X chromosome in trophoblast stem cells. Expressed in embryonic stem cells. Expression increases in prostate during prostate tumor development. Sumoylated, probably by PIAS2. Mice exhibit early embryonic lethality and defects in gastrulation accompanied by reduced methylation of 'Lys-27' of histone H3. Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. Sequence=BAC65495.1; Type=Miscellaneous discrepancy; Note=Unknown reasons.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding sex chromatin chromatin binding RNA binding protein binding nucleus nucleoplasm chromosome nucleolus chromatin organization positive regulation of cell proliferation histone methylation histone ubiquitination RSC complex nuclear body chromatin DNA binding negative regulation of chemokine production protein-DNA complex methylated histone binding ESC/E(Z) complex histone methyltransferase activity negative regulation of tyrosine phosphorylation of STAT protein sequence-specific DNA binding negative regulation of cell differentiation metal ion binding histone methyltransferase activity (H3-K27 specific) negative regulation of epithelial cell proliferation histone H3-K27 trimethylation promoter-specific chromatin binding uc007klc.1 uc007klc.2 
ENSMUST00000017694.7 Atad5 ENSMUST00000017694.7 ATPase family, AAA domain containing 5 (from RefSeq NM_001029856.2) ATAD5_MOUSE ENSMUST00000017694.1 ENSMUST00000017694.2 ENSMUST00000017694.3 ENSMUST00000017694.4 ENSMUST00000017694.5 ENSMUST00000017694.6 Frag1 NM_001029856 Q3TMG5 Q3UW85 Q3V306 Q3V3T9 Q4QY64 Q5SSK4 Q8BUH4 Q8CGG7 uc007klg.1 uc007klg.2 uc007klg.3 Has an important role in DNA replication and in maintaining genome integrity during replication stress. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway. As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle. This seems to be dependent on its ATPase activity. Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR- dependent manner. Ultimately this enables replication fork regression, breakage, and eventual fork restart. Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks. Promotes the generation of MUS81- mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (By similarity). Component of a heteropentameric replication factor ATAD5 RFC- like complex composed of one large subunit (ATAD5) and four small subunits (RFC2, RFC3, RFC4 and RFC5). Within the ATAD5 RFC-like complex, interacts with RFC2, RFC4 and RFC5. Within the ATAD5 RFC-like complex, interacts directly via-N terminal with RAD51; the interactions is enhanced under replication stress (By similarity). Interacts with RB1 predominantly in G1 phase via its LXCXE motif (PubMed:15983387). Interacts with RAD9A in growing cells (PubMed:15983387). The interaction with RAD9A is reduced after exposure to DNA replication- inhibiting agents (PubMed:15983387). Interacts with BRD4. Interacts with PCNA. Interacts with deubiquitinating enzyme USP1, and its associated factor, WDR48 (By similarity). Nucleus Note=Accumulates in nuclear foci at sites of stalled DNA replication forks in response to DNA damage. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q4QY64-1; Sequence=Displayed; Name=2; IsoId=Q4QY64-2; Sequence=VSP_031098, VSP_031099; Expressed ubiquitously in all cell lines like teratocarcinoma, cell lymphoma, lymphoma. Down-regulated by DNA replication-inhibiting agents. ATR may stimulate the RAD9A dissociation. Belongs to the AAA ATPase family. Sequence=AAH38279.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=CAI24765.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAI25200.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAI26037.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding immunoglobulin production DNA binding protein binding ATP binding nucleus cellular response to DNA damage stimulus intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of B cell proliferation Elg1 RFC-like complex nuclear DNA replication B cell proliferation signal transduction in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator isotype switching positive regulation of DNA replication positive regulation of isotype switching to IgG isotypes nucleic acid phosphodiester bond hydrolysis DNA clamp unloading regulation of mitotic cell cycle phase transition negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of cell cycle G2/M phase transition uc007klg.1 uc007klg.2 uc007klg.3 
ENSMUST00000017732.3 Krt27 ENSMUST00000017732.3 keratin 27 (from RefSeq NM_010666.2) ENSMUST00000017732.1 ENSMUST00000017732.2 K1C27_MOUSE Krt1-c29 Krt27 NM_010666 Q9Z320 c29 uc007lip.1 uc007lip.2 uc007lip.3 uc007lip.4 This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The mouse type I keratin genes are clustered in a region of chromosome 11. The encoded protein is involved in the formation of intermediate filaments in the inner root sheath. [provided by RefSeq, Sep 2015]. ##Evidence-Data-START## Transcript exon combination :: BC140996.1, AK077384.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849383, SAMN00849384 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments. Cytoplasm Expressed in skin. Expressed in the Henle layer and cuticle of the irs in hair follicle bulb. In the hair follicle, expression was observed in all layers of the irs but was stronger in the Henle layer and cuticle than the Huxley layer until the Henle layer differentiated (at protein level). There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. structural molecule activity cytoplasm intermediate filament hair follicle morphogenesis uc007lip.1 uc007lip.2 uc007lip.3 uc007lip.4 
ENSMUST00000017741.4 Krt12 ENSMUST00000017741.4 keratin 12 (from RefSeq NM_010661.2) ENSMUST00000017741.1 ENSMUST00000017741.2 ENSMUST00000017741.3 Krt12 NM_010661 Z4YJD9 Z4YJD9_MOUSE uc007lis.1 uc007lis.2 uc007lis.3 Belongs to the intermediate filament family. structural molecule activity intermediate filament uc007lis.1 uc007lis.2 uc007lis.3 
ENSMUST00000017743.3 Krt20 ENSMUST00000017743.3 keratin 20 (from RefSeq NM_023256.2) ENSMUST00000017743.1 ENSMUST00000017743.2 K1C20_MOUSE Krt20 NM_023256 Q6PG82 Q9D312 uc007liu.1 uc007liu.2 uc007liu.3 uc007liu.4 uc007liu.5 This gene encodes a member of the keratin protein family and is found within a cluster of cytokeratin genes on chromosome 11. Keratins are cytoskeletal proteins that are preferentially expressed in epithelial cells. The encoded protein may help maintain intermediate filament organization in intestinal epithelium. Phosphorylation of this protein may also influence mucin secretion in the small intestine. [provided by RefSeq, Dec 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK018567.1, BC057172.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine. Heterotetramer of two type I and two type II keratins. Associates with KRT8. Expressed at low levels in the more differentiated suprabasal regions of the small intestine, and at higher levels in the colon, mainly in the upper region and in scattered cells throughout the remaining epithelium. Also expressed in epithelial cells of bladder, ileum and stomach and at lower levels in pancreas and earskin. The phosphorylated form is nearly exclusively expressed in goblet cells of the small intestine and in the lumen-proximal cells of the colon (at protein level). Also expressed in jejunum and duodenum. Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages (By similarity). Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury. Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-235 (By similarity). There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. structural molecule activity protein binding cytoplasm cytosol intermediate filament apoptotic process cellular response to starvation intermediate filament organization regulation of protein secretion uc007liu.1 uc007liu.2 uc007liu.3 uc007liu.4 uc007liu.5 
ENSMUST00000017751.3 Tns4 ENSMUST00000017751.3 tensin 4 (from RefSeq NM_172564.3) A2A552 ENSMUST00000017751.1 ENSMUST00000017751.2 NM_172564 Q3TCM8 Q7TNR5 Q8BZ33 TENS4_MOUSE uc007lig.1 uc007lig.2 uc007lig.3 Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration. Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF. Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration. Interacts (via SH2 domain) with Rho GTPase-activating protein DLC1 (via C-terminus); the interaction is independent of DLC1 tyrosine phosphorylation. Interacts with integrin ITGB1; the interaction displaces tensin TNS3 from the ITGB1 cytoplasmic tail and promotes ITGB1 stability. Interacts (via SH2 domain) with E3 ubiquitin-protein ligase CBL (phosphorylated on 'Tyr-780'); the interaction is enhanced in the presence of EGF and reduces interaction of CBL with EGFR. Interacts (via SH2 domain) with receptor tyrosine kinase MET (when phosphorylated); the interaction increases MET protein stability. Cell junction, focal adhesion Cytoplasm, cytoskeleton Belongs to the PTEN phosphatase protein family. molecular_function actin binding cytoplasm cytoskeleton focal adhesion apoptotic process protein localization cell junction uc007lig.1 uc007lig.2 uc007lig.3 
ENSMUST00000017783.13 Rab11fip4 ENSMUST00000017783.13 RAB11 family interacting protein 4 (class II) (from RefSeq NM_175543.3) ENSMUST00000017783.1 ENSMUST00000017783.10 ENSMUST00000017783.11 ENSMUST00000017783.12 ENSMUST00000017783.2 ENSMUST00000017783.3 ENSMUST00000017783.4 ENSMUST00000017783.5 ENSMUST00000017783.6 ENSMUST00000017783.7 ENSMUST00000017783.8 ENSMUST00000017783.9 Kiaa1821 NM_175543 Q80T87 Q8BQP8 RFIP4_MOUSE uc007kku.1 uc007kku.2 uc007kku.3 Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development, in a Rab11-independent manner. Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Forms a heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5 (By similarity). Interacts with ECPAS (By similarity). Recycling endosome membrane ; Peripheral membrane protein Cleavage furrow Midbody Cytoplasmic vesicle Note=Recruited to the cleavage furrow and the midbody during cytokinesis. Strongly expressed in the developing retina. Expressed predominantly in neural tissues. The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B). neural retina development calcium ion binding endosome cell cycle membrane Rab GTPase binding endocytic vesicle ADP-ribosylation factor binding midbody cytoplasmic vesicle cleavage furrow endocytic recycling regulation of cytokinesis protein homodimerization activity metal ion binding perinuclear region of cytoplasm cell division recycling endosome membrane positive regulation of G1 to G0 transition centrosome uc007kku.1 uc007kku.2 uc007kku.3 
ENSMUST00000017799.12 Cd40 ENSMUST00000017799.12 CD40 antigen, transcript variant 4 (from RefSeq NM_170704.2) ENSMUST00000017799.1 ENSMUST00000017799.10 ENSMUST00000017799.11 ENSMUST00000017799.2 ENSMUST00000017799.3 ENSMUST00000017799.4 ENSMUST00000017799.5 ENSMUST00000017799.6 ENSMUST00000017799.7 ENSMUST00000017799.8 ENSMUST00000017799.9 NM_170704 P27512 Q3TS33 Q3TSL2 Q3U799 Q3U7C9 Q3UBH3 Q542B1 Q8K2X6 Q99NE0 Q99NE1 Q99NE2 Q99NE3 TNR5_MOUSE Tnfrsf5 uc008nwy.1 uc008nwy.2 uc008nwy.3 Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (PubMed:12881420). Monomer and homodimer. Interacts with TRAF1, TRAF2 and TRAF6 (By similarity). Interacts with TRAF3 and TRAF5. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation. P27512; P35991: Btk; NbExp=3; IntAct=EBI-525742, EBI-625119; P27512; P39429: Traf2; NbExp=3; IntAct=EBI-525742, EBI-520016; P27512; P70196: Traf6; NbExp=2; IntAct=EBI-525742, EBI-448028; [Isoform I]: Cell membrane; Single-pass type I membrane protein. [Isoform III]: Cell membrane; Single-pass type I membrane protein. [Isoform IV]: Cell membrane; Single-pass type I membrane protein. [Isoform V]: Cell membrane; Single-pass type I membrane protein. [Isoform II]: Secreted. Event=Alternative splicing; Named isoforms=5; Name=I; IsoId=P27512-1; Sequence=Displayed; Name=II; IsoId=P27512-2; Sequence=VSP_006474, VSP_006475; Name=III; IsoId=P27512-3; Sequence=VSP_006477, VSP_006478; Name=IV; IsoId=P27512-4; Sequence=VSP_006479, VSP_006480; Name=V; IsoId=P27512-5; Sequence=VSP_006476; positive regulation of protein phosphorylation immune system process immune response-regulating cell surface receptor signaling pathway antigen binding protein binding extracellular region extracellular space cytoplasm plasma membrane cellular calcium ion homeostasis inflammatory response response to bacterium external side of plasma membrane cell surface membrane integral component of membrane enzyme binding protein domain specific binding positive regulation of B cell proliferation ubiquitin protein ligase binding response to nutrient levels positive regulation of interleukin-12 production response to cobalamin response to interferon-gamma CD40 receptor complex cellular response to erythropoietin signaling receptor activity B cell activation positive regulation of tyrosine phosphorylation of STAT protein defense response to protozoan neuronal cell body positive regulation of I-kappaB kinase/NF-kappaB signaling varicosity intracellular membrane-bounded organelle positive regulation of MAP kinase activity protein kinase B signaling positive regulation of blood vessel endothelial cell migration positive regulation of GTPase activity positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgG isotypes regulation of immune response regulation of immunoglobulin secretion positive regulation of NF-kappaB transcription factor activity defense response to virus cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of protein kinase C signaling response to peptide positive regulation of endothelial cell apoptotic process uc008nwy.1 uc008nwy.2 uc008nwy.3 
ENSMUST00000017821.12 Wsb1 ENSMUST00000017821.12 WD repeat and SOCS box-containing 1, transcript variant 1 (from RefSeq NM_019653.3) ENSMUST00000017821.1 ENSMUST00000017821.10 ENSMUST00000017821.11 ENSMUST00000017821.2 ENSMUST00000017821.3 ENSMUST00000017821.4 ENSMUST00000017821.5 ENSMUST00000017821.6 ENSMUST00000017821.7 ENSMUST00000017821.8 ENSMUST00000017821.9 NM_019653 Q3TFQ2 Q3TFQ2_MOUSE Wsb1 uc007kki.1 uc007kki.2 uc007kki.3 Protein modification; protein ubiquitination. protein ubiquitination intracellular signal transduction uc007kki.1 uc007kki.2 uc007kki.3 
ENSMUST00000017836.8 Rhbdl3 ENSMUST00000017836.8 rhomboid like 3 (from RefSeq NM_139228.3) ENSMUST00000017836.1 ENSMUST00000017836.2 ENSMUST00000017836.3 ENSMUST00000017836.4 ENSMUST00000017836.5 ENSMUST00000017836.6 ENSMUST00000017836.7 NM_139228 P58873 RHBL3_MOUSE Rhbdl4 Vrho uc007klt.1 uc007klt.2 uc007klt.3 uc007klt.4 May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; Membrane ; Multi-pass membrane protein At 8 dpc, expression is limited to the developing central nervous system (CNS). From 9 dpc on detected in the ventral forebrain, pretectum, dorsal diencephalon, metencephalon, the ventral spinal neural tube, in the ectoderm of the developing mandibular arches and the developing hindgut. Belongs to the peptidase S54 family. serine-type endopeptidase activity calcium ion binding proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc007klt.1 uc007klt.2 uc007klt.3 uc007klt.4 
ENSMUST00000017839.3 Rnf135 ENSMUST00000017839.3 ring finger protein 135, transcript variant 2 (from RefSeq NR_157298.1) ENSMUST00000017839.1 ENSMUST00000017839.2 NR_157298 Q3UBK5 Q8R161 Q9CWS1 Q9DCH3 RN135_MOUSE Rnf135 uc007kln.1 uc007kln.2 uc007kln.3 E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531). Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:21147464, PubMed:28469175, PubMed:31006531). Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531). This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (PubMed:31006531). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (By similarity). It is not involved in the innate immune response against DNA viruses (PubMed:21147464). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homodimer. Interacts (homodimer) with RIGI (double-stranded RNA-bound oligomeric form); involved in both RIGI ubiquitination, oligomerization into filaments associated with viral RNAs and the bridging of these filaments. Interacts with UBE2D3 and UBE2N; E2 ubiquitin ligases involved in RNF135-mediated ubiquitination of RIGI and activation of the RIG-I signaling pathway. Interacts with PCBP2. Cytoplasm Cytoplasm, Stress granule Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CWS1-1; Sequence=Displayed; Name=2; IsoId=Q9CWS1-2; Sequence=VSP_023787; Ubiquitously expressed. The B30.2/SPRY domain mediates the interaction with the substrate RIGI. The coiled-coil domains mediate homodimerization and the bridging of viral RNA-associated RIGI filaments. Mice lacking Rnf135 develop and breed normally (PubMed:21147464). They are susceptible to RNA viruses infection (PubMed:21147464). immune system process ubiquitin-protein transferase activity protein binding cytoplasm protein ubiquitination transferase activity positive regulation of interferon-beta production identical protein binding ribonucleoprotein complex binding innate immune response regulation of innate immune response metal ion binding uc007kln.1 uc007kln.2 uc007kln.3 
ENSMUST00000017841.4 Ada ENSMUST00000017841.4 adenosine deaminase, transcript variant 5 (from RefSeq NR_184399.1) Ada ENSMUST00000017841.1 ENSMUST00000017841.2 ENSMUST00000017841.3 NR_184399 Q4FK28 Q4FK28_MOUSE uc008ntl.1 uc008ntl.2 uc008ntl.3 uc008ntl.4 Reaction=2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+); Xref=Rhea:RHEA:28190, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17256, ChEBI:CHEBI:28938, ChEBI:CHEBI:28997; EC=3.5.4.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28191; Evidence=; Reaction=adenosine + H(+) + H2O = inosine + NH4(+); Xref=Rhea:RHEA:24408, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16335, ChEBI:CHEBI:17596, ChEBI:CHEBI:28938; EC=3.5.4.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24409; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Cell junction Cell membrane ; Peripheral membrane protein ; Extracellular side Cytoplasmic vesicle lumen Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. response to hypoxia histamine secretion purine nucleoside binding adenosine deaminase activity extracellular space cytoplasm lysosome cytosol plasma membrane adenosine catabolic process aging zinc ion binding purine ribonucleoside monophosphate biosynthetic process external side of plasma membrane cell surface membrane deaminase activity purine nucleotide salvage dendrite cytoplasm response to vitamin E regulation of cell-cell adhesion mediated by integrin T cell activation negative regulation of circadian sleep/wake cycle, non-REM sleep response to drug response to hydrogen peroxide neuronal cell body response to morphine regulation of circadian sleep/wake cycle, sleep adenosine metabolic process inosine biosynthetic process negative regulation of adenosine receptor signaling pathway uc008ntl.1 uc008ntl.2 uc008ntl.3 uc008ntl.4 
ENSMUST00000017851.4 Serinc3 ENSMUST00000017851.4 serine incorporator 3, transcript variant 18 (from RefSeq NR_178197.1) Aigp1 Diff33 ENSMUST00000017851.1 ENSMUST00000017851.2 ENSMUST00000017851.3 NR_178197 Q3U7C6 Q62310 Q8BSP9 Q8CFD3 Q91VN9 Q9QZI9 SERC3_MOUSE Tde1 Tms1 uc008ntg.1 uc008ntg.2 uc008ntg.3 uc008ntg.4 Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm. Cell membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Note=Localizes to the cell membrane, where it is efficiently incorporated into budding gammaretrovirus virions and impairs subsequent virion penetration of susceptible target cells (By similarity). Highly expressed in the neuronal populations such as Purkinje cells in the cerebellum, brainstem and spinal motor neurons, locus coeruleus and raphe nuclei. Highly expressed also in thymus, kidney liver and testis. N-glycosylated. Belongs to the TDE1 family. Sequence=AAA74236.1; Type=Erroneous initiation; Evidence=; Golgi membrane immune system process Golgi apparatus plasma membrane phosphatidylserine metabolic process sphingolipid metabolic process detection of virus membrane integral component of membrane innate immune response defense response to virus positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway uc008ntg.1 uc008ntg.2 uc008ntg.3 uc008ntg.4 
ENSMUST00000017864.3 Trp53tg5 ENSMUST00000017864.3 transformation related protein 53 target 5 (from RefSeq NM_001271575.1) ENSMUST00000017864.1 ENSMUST00000017864.2 NM_001271575 Q9D976 Q9D976_MOUSE Trp53tg5 uc008nuv.1 uc008nuv.2 uc008nuv.3 molecular_function biological_process uc008nuv.1 uc008nuv.2 uc008nuv.3 
ENSMUST00000017881.3 Mmp9 ENSMUST00000017881.3 matrix metallopeptidase 9 (from RefSeq NM_013599.5) Clg4b ENSMUST00000017881.1 ENSMUST00000017881.2 MMP9_MOUSE NM_013599 P41245 Q06788 Q80XI8 Q9DC02 uc008nwt.1 uc008nwt.2 uc008nwt.3 uc008nwt.4 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z27231.1, BC046991.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (By similarity). Could play a role in bone osteoclastic resorption (PubMed:8132709). Cleaves KiSS1 at a Gly-|-Leu bond (By similarity). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:23142597, PubMed:32883094). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz- peptide (By similarity). Reaction=Cleavage of gelatin types I and V and collagen types IV and V.; EC=3.4.24.35; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per subunit. ; Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1. Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with LCN2. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1. Secreted, extracellular space, extracellular matrix Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells. (Microbial infection) Induced in macrophages as well as in whole animals (spleen, lung and liver) by incubation or infection with M.bovis BCG and M.tuberculosis H37Rv (at protein level) (PubMed:11500442). The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. N- and O-glycosylated. Belongs to the peptidase M10A family. skeletal system development positive regulation of protein phosphorylation fibronectin binding positive regulation of leukocyte migration endopeptidase activity metalloendopeptidase activity serine-type endopeptidase activity extracellular region extracellular space proteolysis response to oxidative stress heart development embryo implantation aging peptidase activity metallopeptidase activity zinc ion binding hydrolase activity transformation of host cell by virus extracellular matrix organization positive regulation of cell migration collagen catabolic process extracellular matrix positive regulation of synaptic plasticity macromolecular complex cellular response to reactive oxygen species endodermal cell differentiation response to drug identical protein binding positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of DNA binding macromolecular complex binding positive regulation of epidermal growth factor receptor signaling pathway positive regulation of angiogenesis metal ion binding negative regulation of fibroblast proliferation tissue remodeling protein oligomerization positive regulation of keratinocyte migration cellular response to cadmium ion cellular response to cell-matrix adhesion positive regulation of release of cytochrome c from mitochondria positive regulation of receptor binding response to beta-amyloid positive regulation of vascular smooth muscle cell proliferation negative regulation of epithelial cell differentiation involved in kidney development negative regulation of intrinsic apoptotic signaling pathway negative regulation of cation channel activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway uc008nwt.1 uc008nwt.2 uc008nwt.3 uc008nwt.4 
ENSMUST00000017891.14 Ghdc ENSMUST00000017891.14 GH3 domain containing, transcript variant 4 (from RefSeq NR_184713.1) A2A5D7 D11lgp1e ENSMUST00000017891.1 ENSMUST00000017891.10 ENSMUST00000017891.11 ENSMUST00000017891.12 ENSMUST00000017891.13 ENSMUST00000017891.2 ENSMUST00000017891.3 ENSMUST00000017891.4 ENSMUST00000017891.5 ENSMUST00000017891.6 ENSMUST00000017891.7 ENSMUST00000017891.8 ENSMUST00000017891.9 GHDC_MOUSE Lgp1 NR_184713 Q99J23 Q99J92 uc007lmh.1 uc007lmh.2 uc007lmh.3 Endoplasmic reticulum Nucleus envelope Highly expressed in mammary tissues from mature virgins and at day 13 of pregnancy, and at lower level during lactation. Expressed at intermediate level in liver. Expressed at lower level in kidney, heart and brain. Belongs to the GH3 family. nucleus nuclear envelope cytoplasm endoplasmic reticulum acid-amino acid ligase activity uc007lmh.1 uc007lmh.2 uc007lmh.3 
ENSMUST00000017900.9 Slc12a7 ENSMUST00000017900.9 solute carrier family 12, member 7, transcript variant 1 (from RefSeq NM_011390.2) ENSMUST00000017900.1 ENSMUST00000017900.2 ENSMUST00000017900.3 ENSMUST00000017900.4 ENSMUST00000017900.5 ENSMUST00000017900.6 ENSMUST00000017900.7 ENSMUST00000017900.8 Kcc4 NM_011390 Q3TB23 Q3TDX1 Q3UE50 Q6KAS8 Q9WVL3 S12A7_MOUSE uc007red.1 uc007red.2 uc007red.3 uc007red.4 Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:11551954, PubMed:12106695). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti (PubMed:11976689). May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (Probable). Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out); Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103; Evidence=; Activated by N-ethylmaleimide (NEM). Inhibited by furosemide, DIDS and bumetanide. The inhibition is much stronger in the presence of 50 mM K(+) in the uptake medium. Inhibited by DIOA. Inhibited by WNK3. Homomultimer and heteromultimer with other K-Cl cotransporters. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WVL3-1; Sequence=Displayed; Name=2; IsoId=Q9WVL3-2; Sequence=VSP_027770; Detected in proximal tubules in the kidney, in particular in basolateral membranes of intercalated cells in the cortical collecting duct. In 8 day old mice, before the onset of hearing, detected in membranes of the stria vascularis and in most cells of the organ of Corti. At P14, when the organ of Corti has matured, expression is no longer detected in hair cells and the stria, but is restricted to Deiters' cells that are supporting outer hair cells and to phalangeal cells enveloping the inner hair cells. Glycosylation at Asn-331 and Asn-344 is required for proper trafficking to the cell surface, and augments protein stability. Note=Defects in Slc12a7 are a cause of deafness due to the progressive degeneration of outer and inner hair cells in the cochlea and of neurons in the cochlear ganglion, leading to the loss of the organ of Corti. Belongs to the SLC12A transporter family. Sequence=BAD21379.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE42491.1; Type=Frameshift; Evidence=; plasma membrane integral component of plasma membrane ion transport potassium ion transport cell volume homeostasis chemical synaptic transmission symporter activity cation:chloride symporter activity potassium:chloride symporter activity membrane integral component of membrane protein kinase binding transmembrane transporter activity macromolecular complex chloride ion homeostasis potassium ion homeostasis transmembrane transport chloride transmembrane transport potassium ion import across plasma membrane uc007red.1 uc007red.2 uc007red.3 uc007red.4 
ENSMUST00000017908.3 Zswim1 ENSMUST00000017908.3 zinc finger SWIM-type containing 1 (from RefSeq NM_028028.3) A2A5J3 ENSMUST00000017908.1 ENSMUST00000017908.2 NM_028028 Q8R163 Q9CWV7 ZSWM1_MOUSE uc008nwi.1 uc008nwi.2 uc008nwi.3 Sequence=AAH25184.1; Type=Erroneous initiation; Evidence=; molecular_function nucleus biological_process zinc ion binding metal ion binding uc008nwi.1 uc008nwi.2 uc008nwi.3 
ENSMUST00000017911.4 Spata25 ENSMUST00000017911.4 spermatogenesis associated 25 (from RefSeq NM_029370.1) A2A5J4 ENSMUST00000017911.1 ENSMUST00000017911.2 ENSMUST00000017911.3 NM_029370 Q14B41 Q9DA57 SPT25_MOUSE Tsg23 uc008nwj.1 uc008nwj.2 uc008nwj.3 uc008nwj.4 May play a role in spermatogenesis. Membrane ; Single-pass membrane protein Expressed strongly in testis, weakly in epididymis and not detected in other tissues. Expression is detected at day 15 after birth and gradually increases from day 15 to 5 months. Expression is found in round spermatids with little expression in spermatogonia. Belongs to the SPATA25 family. molecular_function cellular_component spermatogenesis membrane integral component of membrane cell differentiation uc008nwj.1 uc008nwj.2 uc008nwj.3 uc008nwj.4 
ENSMUST00000017920.14 Crk ENSMUST00000017920.14 v-crk avian sarcoma virus CT10 oncogene homolog, transcript variant 2 (from RefSeq NM_133656.5) CRK_MOUSE Crko ENSMUST00000017920.1 ENSMUST00000017920.10 ENSMUST00000017920.11 ENSMUST00000017920.12 ENSMUST00000017920.13 ENSMUST00000017920.2 ENSMUST00000017920.3 ENSMUST00000017920.4 ENSMUST00000017920.5 ENSMUST00000017920.6 ENSMUST00000017920.7 ENSMUST00000017920.8 ENSMUST00000017920.9 NM_133656 Q64010 uc007ker.1 uc007ker.2 uc007ker.3 uc007ker.4 This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In mouse this protein is essential for embryonic development. Alternatively spliced transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Mar 2013]. Involved in cell branching and adhesion mediated by BCAR1- CRK-RAPGEF1 signaling and activation of RAP1. Isoform CRK-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (By similarity). May regulate the EFNA5-EPHA3 signaling (PubMed:11870224). Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (By similarity). Within the complex, interacts with SH2D3C (via C- terminus), and BCAR1/CAS (By similarity). Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases (By similarity). Interacts with ABL1, C3G, DOCK3, DOCK5, MAP4K1, MAPK8 and SOS via its first SH3 domain. Interacts (via SH2 domain) with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 upon stimulus-induced tyrosine phosphorylation. Interacts (via SH2 domain) with several tyrosine-phosphorylated growth factor receptors such as EGFR and INSR. Interacts with FLT1 (tyrosine-phosphorylated). Interacts with DOCK1 and DOCK4. Interacts with SHB. Interacts with PEAK1. Interacts with FASLG. Interacts with FLT4 (tyrosine-phosphorylated). Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and p130cas/BCAR1. Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1. Interacts with CBLC (By similarity). [Isoform Crk-II]: Interacts (via SH2 domain) with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated) (By similarity). Interacts with EPHA3 (phosphorylated); upon activation of EPHA3 by the ligand EFNA5 and EPHA3 tyrosine kinase activity-dependent and mediates EFNA5-EPHA3 signaling through RHOA GTPase activation (PubMed:11870224). Interacts with KIT (PubMed:12878163). Interacts with PEAK3; the interaction requires PEAK3 homodimerization (By similarity). Q64010; P08069: IGF1R; Xeno; NbExp=3; IntAct=EBI-2906540, EBI-475981; Cytoplasm Cell membrane Note=Translocated to the plasma membrane upon cell adhesion. Event=Alternative splicing; Named isoforms=2; Name=Crk-II; IsoId=Q64010-1; Sequence=Displayed; Name=Crk-I; IsoId=Q64010-2; Sequence=VSP_004174; Ubiquitous. The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation. The SH2 domain mediates interaction with tyrosine phosphorylated proteins. Mediates interaction with SHB. Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway (PubMed:8194526, PubMed:12878163). Isoform Crk-II: Phosphorylated by KIT (By similarity). Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form. Belongs to the CRK family. neuron migration phosphotyrosine binding response to yeast regulation of leukocyte migration SH3/SH2 adaptor activity insulin-like growth factor receptor binding protein binding cytoplasm plasma membrane lipid metabolic process cytoskeletal protein binding regulation of cell shape regulation of signal transduction positive regulation of signal transduction positive regulation of smooth muscle cell migration actin cytoskeleton membrane dendrite development SH3 domain binding enzyme binding protein domain specific binding hippocampus development cerebral cortex development establishment of cell polarity positive regulation of cell growth protein binding, bridging regulation of actin cytoskeleton organization macromolecular complex regulation of cell adhesion mediated by integrin regulation of Rac protein signal transduction helper T cell diapedesis response to hepatocyte growth factor reelin-mediated signaling pathway SH2 domain binding response to hydrogen peroxide regulation of GTPase activity regulation of protein binding protein self-association membrane raft protein phosphorylated amino acid binding negative regulation of natural killer cell mediated cytotoxicity ephrin receptor binding ephrin receptor signaling pathway regulation of dendrite development cell chemotaxis negative regulation of wound healing cellular response to transforming growth factor beta stimulus cellular response to nitric oxide activation of GTPase activity scaffold protein binding cerebellar neuron development positive regulation of substrate adhesion-dependent cell spreading response to peptide cellular response to nerve growth factor stimulus cellular response to insulin-like growth factor stimulus protein tyrosine kinase binding cellular response to endothelin negative regulation of cell motility regulation of T cell migration uc007ker.1 uc007ker.2 uc007ker.3 uc007ker.4 
ENSMUST00000017946.6 Retreg3 ENSMUST00000017946.6 reticulophagy regulator family member 3, transcript variant 1 (from RefSeq NM_026501.3) ENSMUST00000017946.1 ENSMUST00000017946.2 ENSMUST00000017946.3 ENSMUST00000017946.4 ENSMUST00000017946.5 Fam134c NM_026501 Q3TQL8 Q3U9Q7 Q8BQC4 Q922X3 Q9CQV4 RETR3_MOUSE uc007lni.1 uc007lni.2 uc007lni.3 Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (By similarity). Required for collagen quality control in a LIR motif-dependent manner (PubMed:34338405). Mediates NRF1- enhanced neurite outgrowth (By similarity). Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAPL1 and GABARAPL2 (PubMed:34338405). Also interacts with ATG8 family modifier protein GABARAP (By similarity). Interacts with CANX (By similarity). Interacts with RTN4 isoform B (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Localizes preferentially to endoplasmic reticulum tubules and sheet edges. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQV4-1; Sequence=Displayed; Name=2; IsoId=Q9CQV4-2; Sequence=VSP_025689; Widely expressed with highest levels in brain, lung, liver, muscle and spleen (protein level) (PubMed:34338405). Mainly expressed in the central nervous system and in parenchymatous organs including liver, lung and kidney. The LIR motif interacts with ATG8 family proteins. Belongs to the RETREG family. molecular_function positive regulation of neuron projection development membrane integral component of membrane macromolecular complex uc007lni.1 uc007lni.2 uc007lni.3 
ENSMUST00000017974.13 Dhx58 ENSMUST00000017974.13 DExH-box helicase 58 (from RefSeq NM_030150.2) A2A5E9 D11lgp2e DHX58_MOUSE Dhx58 ENSMUST00000017974.1 ENSMUST00000017974.10 ENSMUST00000017974.11 ENSMUST00000017974.12 ENSMUST00000017974.2 ENSMUST00000017974.3 ENSMUST00000017974.4 ENSMUST00000017974.5 ENSMUST00000017974.6 ENSMUST00000017974.7 ENSMUST00000017974.8 ENSMUST00000017974.9 Lgp2 NM_030150 Q99J87 Q9D1X4 uc007llx.1 uc007llx.2 Acts as a regulator of RIGI and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to RIGI and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on RIG- I signaling may involve the following mechanisms: competition with RIGI for binding to the viral RNA, binding to RIGI and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by RIGI and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Monomer in the absence of dsRNA. Homodimer in the presence of dsRNA. Interacts with RIGI (via CARD domain), MAVS/IPS1 and DDX60. Found in a complex with RIGI and IFIH1/MDA5. Interacts with ANKRD17. Directly interacts with ATG5 and ATG12, either as ATG5 and ATG12 monomers or as ATG12-ATG5 conjugates (By similarity). Cytoplasm Highly expressed in mammary tissues. Expressed in liver and testis. Expressed at lower level in spleen, embryo, mammary gland and breast tumors. By interferon (IFN), virus infection, or intracellular dsRNA. The RLR CTR domain is capable of inhibiting dimerization and signaling of RIGI and also facilitates binding of dsRNA. Embryonic lethality at a high frequency. Adult female that survive show an enlarged uterus filled with fluid resulting from vaginal atresia. Belongs to the helicase family. RLR subfamily. nucleotide binding immune system process DNA binding RNA binding RNA helicase activity double-stranded RNA binding single-stranded RNA binding helicase activity ATP binding cytoplasm zinc ion binding response to virus response to bacterium hydrolase activity negative regulation of type I interferon production positive regulation of type I interferon production negative regulation of MDA-5 signaling pathway negative regulation of RIG-I signaling pathway innate immune response regulation of innate immune response negative regulation of innate immune response metal ion binding defense response to virus positive regulation of MDA-5 signaling pathway positive regulation of RIG-I signaling pathway uc007llx.1 uc007llx.2 
ENSMUST00000017975.7 Rab5a ENSMUST00000017975.7 RAB5A, member RAS oncogene family (from RefSeq NM_025887.4) ENSMUST00000017975.1 ENSMUST00000017975.2 ENSMUST00000017975.3 ENSMUST00000017975.4 ENSMUST00000017975.5 ENSMUST00000017975.6 NM_025887 Q3UCX7 Q4VAA1 Q9CQD1 Q9DCN5 RAB5A_MOUSE nnyRab5a uc008czn.1 uc008czn.2 uc008czn.3 Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (By similarity). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (PubMed:18425118). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Interacts with GDI1; this promotes dissociation from membranes; phosphorylation at Ser-84 disrupts this interaction (By similarity). Interacts with GDI2; phosphorylation at Ser-84 disrupts the interaction (By similarity). Interacts with EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with RINL. Interacts with ALS2CL, SUN2, ZFYVE20 and RUFY1. Interacts with RABEP1; one RABEP1 homodimer binds two RAB5A chains, but at opposite sides of the dimer (By similarity). Interacts with SGSM1 and SGSM3 (PubMed:17509819). Interacts with PIK3CB (PubMed:21059846). Interacts with OCRL and INPP5F (PubMed:25869668). May be a component of a complex composed of RAB5A, DYN2 and PIK3C3 (PubMed:18425118). Does not interact with BLOC-3 complex (heterodimer of HPS1 and HPS4). Interacts with CLN5 (By similarity). Interacts with APPL2 (PubMed:25568335). Interacts with F8A1/F8A2/F8A3 (By similarity). Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity). Interacts with ATP9A (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Early endosome membrane ; Lipid-anchor Melanosome Cytoplasmic vesicle Cell projection, ruffle Membrane Cytoplasm, cytosol Cytoplasmic vesicle, phagosome membrane Endosome membrane Note=Enriched in stage I melanosomes. Alternates between membrane-bound and cytosolic forms. Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2. Belongs to the small GTPase superfamily. Rab family. nucleotide binding ruffle GTPase activity protein binding GTP binding cytoplasm endosome early endosome cytosol plasma membrane intracellular protein transport endocytosis phagocytosis endosome organization synaptic vesicle endosome membrane positive regulation of smooth muscle cell migration protein transport actin cytoskeleton membrane guanyl nucleotide binding GDP binding endocytic vesicle axon dendrite phagocytic vesicle membrane cytoplasmic vesicle early endosome membrane early phagosome Rab protein signal transduction macromolecular complex synaptic vesicle recycling somatodendritic compartment viral RNA genome replication melanosome zymogen granule membrane cell projection neuron projection neuronal cell body terminal bouton axon terminus early endosome to late endosome transport membrane raft phagocytic vesicle positive regulation of exocytosis regulation of long-term neuronal synaptic plasticity perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation GDP-dissociation inhibitor binding regulation of endosome size regulation of filopodium assembly recycling endosome cytoplasmic side of early endosome membrane postsynaptic early endosome anchored component of synaptic vesicle membrane receptor internalization involved in canonical Wnt signaling pathway regulation of synaptic vesicle exocytosis uc008czn.1 uc008czn.2 uc008czn.3 
ENSMUST00000017976.3 Hspb9 ENSMUST00000017976.3 heat shock protein, alpha-crystallin-related, B9 (from RefSeq NM_029307.2) A2A5F2 ENSMUST00000017976.1 ENSMUST00000017976.2 HSPB9_MOUSE NM_029307 Q9DAM3 uc288cfl.1 uc288cfl.2 Cytoplasm Nucleus Note=Translocates to nuclear foci during heat shock. Testis specific. Expressed notably in the spermatogenic cells from late pachytene spermatocyte stage till elongate spermatid stage. Belongs to the small heat shock protein (HSP20) family. molecular_function nucleus cytoplasm biological_process uc288cfl.1 uc288cfl.2 
ENSMUST00000018002.13 Ift52 ENSMUST00000018002.13 intraflagellar transport 52, transcript variant 2 (from RefSeq NM_172150.5) ENSMUST00000018002.1 ENSMUST00000018002.10 ENSMUST00000018002.11 ENSMUST00000018002.12 ENSMUST00000018002.2 ENSMUST00000018002.3 ENSMUST00000018002.4 ENSMUST00000018002.5 ENSMUST00000018002.6 ENSMUST00000018002.7 ENSMUST00000018002.8 ENSMUST00000018002.9 IFT52_MOUSE NM_172150 Ngd5 Q3TK21 Q62559 Q8BTX3 Q8CI16 uc008nsj.1 uc008nsj.2 uc008nsj.3 Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia (PubMed:19253336). Required for the anterograde transport of IFT88 (By similarity). Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (PubMed:19253336). Interacts with IFT88 (PubMed:19253336). Interacts with TTC25 (PubMed:25860617). Interacts with TTC21A (By similarity). Interacts with IFT70A1, IFT70A2, IFT70B and KIF17 (PubMed:23810713). Interacts with USH1G (By similarity). Q62559; Q8N4P2: IFT70B; Xeno; NbExp=2; IntAct=EBI-6959048, EBI-6958994; Cell projection, cilium After opioid treatment, expression decreases. Sequence=AAA96241.1; Type=Frameshift; Evidence=; neural tube formation heart looping protein binding centrosome centriole cilium smoothened signaling pathway determination of left/right symmetry dorsal/ventral pattern formation cell projection organization intraciliary transport particle B photoreceptor connecting cilium intraciliary anterograde transport ciliary basal body intraciliary transport embryonic digit morphogenesis cell projection dendrite terminus negative regulation of epithelial cell proliferation cilium assembly regulation of protein processing ciliary tip ciliary base photoreceptor cell cilium non-motile cilium assembly uc008nsj.1 uc008nsj.2 uc008nsj.3 
ENSMUST00000018005.10 Mybl2 ENSMUST00000018005.10 myeloblastosis oncogene-like 2 (from RefSeq NM_008652.2) Bmyb ENSMUST00000018005.1 ENSMUST00000018005.2 ENSMUST00000018005.3 ENSMUST00000018005.4 ENSMUST00000018005.5 ENSMUST00000018005.6 ENSMUST00000018005.7 ENSMUST00000018005.8 ENSMUST00000018005.9 MYBB_MOUSE NM_008652 P48972 uc008nsl.1 uc008nsl.2 uc008nsl.3 Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (By similarity). Interacts with CCNF (via the Cyclin N- terminal domain) (By similarity). Nucleus. Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-524 is probably involved in transcriptional activity (By similarity). mitotic cell cycle RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus nucleoplasm Myb complex positive regulation of neuron apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter mitotic spindle assembly cellular response to leukemia inhibitory factor uc008nsl.1 uc008nsl.2 uc008nsl.3 
ENSMUST00000018012.14 Sgk2 ENSMUST00000018012.14 serum/glucocorticoid regulated kinase 2, transcript variant 1 (from RefSeq NM_013731.3) B7ZC31 ENSMUST00000018012.1 ENSMUST00000018012.10 ENSMUST00000018012.11 ENSMUST00000018012.12 ENSMUST00000018012.13 ENSMUST00000018012.2 ENSMUST00000018012.3 ENSMUST00000018012.4 ENSMUST00000018012.5 ENSMUST00000018012.6 ENSMUST00000018012.7 ENSMUST00000018012.8 ENSMUST00000018012.9 NM_013731 Q8R0P6 Q9QZS5 SGK2_MOUSE uc008nsg.1 uc008nsg.2 uc008nsg.3 uc008nsg.4 uc008nsg.5 Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Two specific sites, one in the kinase domain (Thr- 193) and the other in the C-terminal regulatory region (Ser-356), need to be phosphorylated for its full activation. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QZS5-1; Sequence=Displayed; Name=2; IsoId=Q9QZS5-2; Sequence=VSP_004933; Activated by phosphorylation on Ser-356 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-193. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Not regulated by serum or glucocorticoids. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding cellular_component nucleus nucleoplasm cytoplasm protein phosphorylation potassium channel regulator activity kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction uc008nsg.1 uc008nsg.2 uc008nsg.3 uc008nsg.4 uc008nsg.5 
ENSMUST00000018066.13 Prl3c1 ENSMUST00000018066.13 prolactin family 3, subfamily c, member 1, transcript variant 1 (from RefSeq NM_013766.2) ENSMUST00000018066.1 ENSMUST00000018066.10 ENSMUST00000018066.11 ENSMUST00000018066.12 ENSMUST00000018066.2 ENSMUST00000018066.3 ENSMUST00000018066.4 ENSMUST00000018066.5 ENSMUST00000018066.6 ENSMUST00000018066.7 ENSMUST00000018066.8 ENSMUST00000018066.9 NM_013766 PR3C1_MOUSE Prlpi Prlpj Q5SZY4 Q9QUN5 uc007pxh.1 uc007pxh.2 uc007pxh.3 uc007pxh.4 uc007pxh.5 uc007pxh.6 Secreted Expressed exclusively in decidua. Belongs to the somatotropin/prolactin family. Sequence=CAI24361.1; Type=Erroneous initiation; Evidence=; prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pxh.1 uc007pxh.2 uc007pxh.3 uc007pxh.4 uc007pxh.5 uc007pxh.6 
ENSMUST00000018094.13 Hnf4a ENSMUST00000018094.13 hepatic nuclear factor 4, alpha, transcript variant 1 (from RefSeq NM_008261.3) A2A5I5 A2ICH0 ENSMUST00000018094.1 ENSMUST00000018094.10 ENSMUST00000018094.11 ENSMUST00000018094.12 ENSMUST00000018094.2 ENSMUST00000018094.3 ENSMUST00000018094.4 ENSMUST00000018094.5 ENSMUST00000018094.6 ENSMUST00000018094.7 ENSMUST00000018094.8 ENSMUST00000018094.9 HNF4A_MOUSE Hnf-4 Hnf4 NM_008261 Nr2a1 P49698 Q3UNX3 Q8CFY1 Tcf14 uc008ntb.1 uc008ntb.2 uc008ntb.3 uc008ntb.4 The protein encoded by this gene is a transcription factor involved in the development of the pancreas, liver, kidney, and intestines. The encoded protein also functions to maintain glucose homeostasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]. Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitatating the recruitment of RNA pol II to the promoters of target genes (By similarity). Activates the transcription of CYP2C38 (PubMed:30555544). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). Homodimerization is required for HNF4-alpha to bind to its recognition site (By similarity). Interacts with CLOCK, BMAL1 and PER1 (By similarity). Interacts with PER2 (PubMed:20159955). Interacts with CRY1 and CRY2 (PubMed:28751364). Interacts with NR0B2/SHP; the resulting heterodimer is transcriptionally inactive (By similarity). Interacts with DDX3X; this interaction disrupts the interaction between HNF4 and NR0B2 that forms inactive heterodimers and enhances the formation of active HNF4 homodimers (By similarity). Nucleus. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P49698-1; Sequence=Displayed; Name=Short; IsoId=P49698-2; Sequence=VSP_003676; Expressed in the liver, pancreas and colon in a circadian manner. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA (By similarity). Acetylation at Lys-458 lowers transcriptional activation by about two-fold. Pancreatic beta-cells-specific knockout results in hyperinsulinemia and hypoglycemia. Binds fatty acids. Belongs to the nuclear hormone receptor family. NR2 subfamily. Sequence=BAA06101.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; fatty-acyl-CoA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding type B pancreatic cell development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity receptor binding fatty acid binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter ornithine metabolic process lipid metabolic process acyl-CoA metabolic process xenobiotic metabolic process establishment of tissue polarity sex differentiation blood coagulation transcription factor binding zinc ion binding negative regulation of cell proliferation response to glucose regulation of gastrulation palmitoyl-CoA hydrolase activity regulation of lipid metabolic process signal transduction involved in regulation of gene expression cell differentiation negative regulation of cell growth negative regulation of cell migration endocrine pancreas development regulation of microvillus assembly long-chain fatty acyl-CoA binding negative regulation of tyrosine phosphorylation of STAT protein glucose homeostasis cholesterol homeostasis regulation of circadian rhythm protein homodimerization activity steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding transcription regulatory region DNA binding cell-cell junction organization positive regulation of gluconeogenesis positive regulation of fatty acid biosynthetic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter metal ion binding rhythmic process anatomical structure development arachidonic acid binding regulation of insulin secretion lipid homeostasis phospholipid homeostasis SMAD protein signal transduction triglyceride homeostasis hepatocyte differentiation repressing transcription factor binding stearic acid binding negative regulation of activation of JAK2 kinase activity uc008ntb.1 uc008ntb.2 uc008ntb.3 uc008ntb.4 
ENSMUST00000018113.8 Ptgis ENSMUST00000018113.8 prostaglandin I2 (prostacyclin) synthase, transcript variant 1 (from RefSeq NM_008968.5) Cyp8 ENSMUST00000018113.1 ENSMUST00000018113.2 ENSMUST00000018113.3 ENSMUST00000018113.4 ENSMUST00000018113.5 ENSMUST00000018113.6 ENSMUST00000018113.7 NM_008968 O35074 PTGIS_MOUSE uc008nzl.1 uc008nzl.2 uc008nzl.3 Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)- hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE). Reaction=prostaglandin H2 = prostaglandin I2; Xref=Rhea:RHEA:23580, ChEBI:CHEBI:57403, ChEBI:CHEBI:57405; EC=5.3.99.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23581; Evidence=; Reaction=a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O; Xref=Rhea:RHEA:55556, ChEBI:CHEBI:15377, ChEBI:CHEBI:59720, ChEBI:CHEBI:131859; EC=4.2.1.152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55557; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo- (5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O; Xref=Rhea:RHEA:48856, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:57409, ChEBI:CHEBI:57446; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane ; Single-pass membrane protein Belongs to the cytochrome P450 family. prostaglandin biosynthetic process response to hypoxia monooxygenase activity iron ion binding extracellular space nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane caveola lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process embryo implantation prostaglandin-I synthase activity membrane integral component of membrane oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen isomerase activity heme binding negative regulation of NF-kappaB transcription factor activity positive regulation of peroxisome proliferator activated receptor signaling pathway negative regulation of nitric oxide biosynthetic process positive regulation of angiogenesis decidualization metal ion binding negative regulation of inflammatory response oxidation-reduction process cellular response to interleukin-1 cellular response to interleukin-6 cellular response to hypoxia apoptotic signaling pathway positive regulation of execution phase of apoptosis uc008nzl.1 uc008nzl.2 uc008nzl.3 
ENSMUST00000018143.16 Ddx27 ENSMUST00000018143.16 DEAD box helicase 27 (from RefSeq NM_153065.3) DDX27_MOUSE ENSMUST00000018143.1 ENSMUST00000018143.10 ENSMUST00000018143.11 ENSMUST00000018143.12 ENSMUST00000018143.13 ENSMUST00000018143.14 ENSMUST00000018143.15 ENSMUST00000018143.2 ENSMUST00000018143.3 ENSMUST00000018143.4 ENSMUST00000018143.5 ENSMUST00000018143.6 ENSMUST00000018143.7 ENSMUST00000018143.8 ENSMUST00000018143.9 NM_153065 Q3UUG2 Q8R0W3 Q8R1E2 Q921N6 uc008nzb.1 uc008nzb.2 uc008nzb.3 Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Associates with PeBoW complex, composed of BOP1, PES1 and WDR12. Interacts directly with BOP1 and PES1. Nucleus, nucleolus Chromosome Note=Associates with 60S and 90S pre- ribosomal particles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q921N6-1; Sequence=Displayed; Name=2; IsoId=Q921N6-2; Sequence=VSP_007073, VSP_007074; The C-terminal domain regulates nucleolar localization. Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily. Sequence=AAH11321.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus chromosome nucleolus rRNA processing hydrolase activity ribosome biogenesis uc008nzb.1 uc008nzb.2 uc008nzb.3 
ENSMUST00000018156.12 Rac3 ENSMUST00000018156.12 Rac family small GTPase 3 (from RefSeq NM_133223.4) ENSMUST00000018156.1 ENSMUST00000018156.10 ENSMUST00000018156.11 ENSMUST00000018156.2 ENSMUST00000018156.3 ENSMUST00000018156.4 ENSMUST00000018156.5 ENSMUST00000018156.6 ENSMUST00000018156.7 ENSMUST00000018156.8 ENSMUST00000018156.9 NM_133223 Q14A12 Q14A12_MOUSE Rac3 uc007mug.1 uc007mug.2 uc007mug.3 nucleotide binding GTPase activity GTP binding small GTPase mediated signal transduction endomembrane system cell projection assembly actin cytoskeleton organization growth cone filamentous actin positive regulation of cell adhesion mediated by integrin neuron projection neuronal cell body calcium-dependent protein binding perinuclear region of cytoplasm cell periphery positive regulation of substrate adhesion-dependent cell spreading uc007mug.1 uc007mug.2 uc007mug.3 
ENSMUST00000018184.10 Rrp7a ENSMUST00000018184.10 ribosomal RNA processing 7 homolog A, transcript variant 1 (from RefSeq NM_029101.4) ENSMUST00000018184.1 ENSMUST00000018184.2 ENSMUST00000018184.3 ENSMUST00000018184.4 ENSMUST00000018184.5 ENSMUST00000018184.6 ENSMUST00000018184.7 ENSMUST00000018184.8 ENSMUST00000018184.9 NM_029101 Q3TWT8 Q8CCK8 Q9D1C9 RRP7A_MOUSE uc007wzy.1 uc007wzy.2 uc007wzy.3 uc007wzy.4 uc007wzy.5 Nucleolar protein that is involved in ribosomal RNA (rRNA) processing. Also plays a role in primary cilia resorption, and cell cycle progression in neurogenesis and neocortex development. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with NOL6; required for NOL6 localization to nucleolus. Nucleus, nucleolus Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Belongs to the RRP7 family. ribosomal small subunit assembly blastocyst formation nucleic acid binding RNA binding cytoplasm rRNA processing CURI complex UTP-C complex uc007wzy.1 uc007wzy.2 uc007wzy.3 uc007wzy.4 uc007wzy.5 
ENSMUST00000018186.16 Cyb5r3 ENSMUST00000018186.16 cytochrome b5 reductase 3 (from RefSeq NM_029787.3) Cyb5r3 Dia1 ENSMUST00000018186.1 ENSMUST00000018186.10 ENSMUST00000018186.11 ENSMUST00000018186.12 ENSMUST00000018186.13 ENSMUST00000018186.14 ENSMUST00000018186.15 ENSMUST00000018186.2 ENSMUST00000018186.3 ENSMUST00000018186.4 ENSMUST00000018186.5 ENSMUST00000018186.6 ENSMUST00000018186.7 ENSMUST00000018186.8 ENSMUST00000018186.9 NB5R3_MOUSE NM_029787 Q9DCN2 uc007xac.1 uc007xac.2 uc007xac.3 uc007xac.4 Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor. Reaction=2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+); Xref=Rhea:RHEA:46680, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46681; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Component of a complex composed of cytochrome b5, NADH- cytochrome b5 reductase (CYB5R3) and MTARC2 (By similarity). Interacts with MTLN; the interaction is required to maintain cellular lipid composition and leads to stimulation of mitochondrial respiratory complex I activity (PubMed:31296841). Endoplasmic reticulum membrane ; Lipid-anchor ; Cytoplasmic side Mitochondrion outer membrane ; Lipid-anchor ; Cytoplasmic side Event=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=M; IsoId=Q9DCN2-1; Sequence=Displayed; Name=2; Synonyms=S; IsoId=Q9DCN2-2; Sequence=VSP_012952; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. cytochrome-b5 reductase activity, acting on NAD(P)H protein binding cytoplasm mitochondrion mitochondrial outer membrane mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum membrane lipid particle lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process steroid metabolic process cholesterol metabolic process membrane sterol biosynthetic process AMP binding oxidoreductase activity ADP binding flavin adenine dinucleotide binding NAD binding oxidation-reduction process FAD binding uc007xac.1 uc007xac.2 uc007xac.3 uc007xac.4 
ENSMUST00000018212.13 Ints2 ENSMUST00000018212.13 integrator complex subunit 2, transcript variant 2 (from RefSeq NM_027421.3) ENSMUST00000018212.1 ENSMUST00000018212.10 ENSMUST00000018212.11 ENSMUST00000018212.12 ENSMUST00000018212.2 ENSMUST00000018212.3 ENSMUST00000018212.4 ENSMUST00000018212.5 ENSMUST00000018212.6 ENSMUST00000018212.7 ENSMUST00000018212.8 ENSMUST00000018212.9 INT2_MOUSE Kiaa1287 NM_027421 Q5SXZ5 Q5SXZ6 Q6PCY7 Q6ZPU6 Q80UK8 Q8CB15 Q9CSE0 uc007ksj.1 uc007ksj.2 uc007ksj.3 Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Nucleus membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80UK8-1; Sequence=Displayed; Name=2; IsoId=Q80UK8-2; Sequence=VSP_018574, VSP_018575; Belongs to the Integrator subunit 2 family. Sequence=BAC98133.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function nucleus cytoplasm membrane integral component of membrane snRNA processing nuclear membrane integrator complex snRNA 3'-end processing uc007ksj.1 uc007ksj.2 uc007ksj.3 
ENSMUST00000018246.6 H2bc4 ENSMUST00000018246.6 H2B clustered histone 4, transcript variant 1 (from RefSeq NM_023422.3) ENSMUST00000018246.1 ENSMUST00000018246.2 ENSMUST00000018246.3 ENSMUST00000018246.4 ENSMUST00000018246.5 H2B1C_MOUSE H2bc4 H2bc6 H2bc8 Hist1h2bc Hist1h2be Hist1h2bg NM_023422 Q6ZWY9 uc007pul.1 uc007pul.2 uc007pul.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome innate immune response in mucosa DNA binding extracellular space nucleus nucleoplasm chromosome cytosol nucleosome assembly antibacterial humoral response identical protein binding protein heterodimerization activity defense response to Gram-positive bacterium uc007pul.1 uc007pul.2 uc007pul.3 
ENSMUST00000018274.10 Csnk1d ENSMUST00000018274.10 casein kinase 1, delta, transcript variant 1 (from RefSeq NM_139059.3) ENSMUST00000018274.1 ENSMUST00000018274.2 ENSMUST00000018274.3 ENSMUST00000018274.4 ENSMUST00000018274.5 ENSMUST00000018274.6 ENSMUST00000018274.7 ENSMUST00000018274.8 ENSMUST00000018274.9 Hckid KC1D_MOUSE NM_139059 Q3TZK2 Q99KK4 Q9DC28 uc007mvb.1 uc007mvb.2 uc007mvb.3 This gene encodes a member of the casein kinase I (CKI) family of serine/threonine protein kinases. A highly similar human protein regulates an array of cellular processes by influencing the Wnt and hedgehog signaling pathways. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (PubMed:29191835). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Reaction=ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl- [tau protein]; Xref=Rhea:RHEA:12801, Rhea:RHEA-COMP:13701, Rhea:RHEA- COMP:13702, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.26; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12802; Evidence=; Reaction=ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L- threonyl-[tau protein]; Xref=Rhea:RHEA:53904, Rhea:RHEA-COMP:13703, Rhea:RHEA-COMP:13704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.26; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53905; Evidence=; Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by phosphorylation (By similarity). Monomer (By similarity). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (PubMed:11779462). Interacts directly with PER1 and PER2 which may lead to their degradation (By similarity). Interacts with MAP1A (By similarity). Interacts with MAPT/TAU, DBNDD2, AIB1/NCOA3 and ESR1 (By similarity). Interacts with AKAP9/AKAP450; this interaction promotes centrosomal subcellular location (By similarity). Binds to tubulins in mitotic cells upon DNA damage (By similarity). Interacts with GJA1 (By similarity). Interacts with SNAPIN (PubMed:17101137). Interacts with DNMT1 (PubMed:20192920). Interacts with DDX3X; this interaction enhances CSNK1D kinase activity in vitro, but it is unclear whether this interaction is physiologically relevant (By similarity). Cytoplasm Nucleus toplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, perinuclear region Cell membrane Cytoplasm, cytoskeleton, spindle Golgi apparatus Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DC28-1; Sequence=Displayed; Name=2; IsoId=Q9DC28-2; Sequence=VSP_010254; Expressed ubiquitously. However, kinase activity is not uniform, with highest kinase activity in splenocytes. Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase- mediated dephosphorylation. May be dephosphorylated by PP1. Lethal. There are fewer embryos than expected at late stages of gestation; they weigh about 30% less than control animals, but appear otherwise normal. Mice die shortly after birth. Tissue-specific disruption increases the half-life of PER2 protein and alters circadian protein expression dynamics. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. nucleotide binding positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm Golgi apparatus centrosome microtubule organizing center spindle cytosol cytoskeleton spindle microtubule plasma membrane protein phosphorylation microtubule nucleation Golgi organization membrane Wnt signaling pathway kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation positive regulation of Wnt signaling pathway positive regulation of proteasomal ubiquitin-dependent protein catabolic process circadian regulation of gene expression protein localization to Golgi apparatus regulation of circadian rhythm neuron projection perinuclear region of cytoplasm rhythmic process tau-protein kinase activity spindle assembly protein localization to cilium protein localization to centrosome positive regulation of canonical Wnt signaling pathway positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation non-motile cilium assembly cellular response to nerve growth factor stimulus positive regulation of non-canonical Wnt signaling pathway uc007mvb.1 uc007mvb.2 uc007mvb.3 
ENSMUST00000018287.10 Mafk ENSMUST00000018287.10 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) (from RefSeq NM_010757.2) ENSMUST00000018287.1 ENSMUST00000018287.2 ENSMUST00000018287.3 ENSMUST00000018287.4 ENSMUST00000018287.5 ENSMUST00000018287.6 ENSMUST00000018287.7 ENSMUST00000018287.8 ENSMUST00000018287.9 MAFK_MOUSE NM_010757 Nfe2u Q60600 Q61827 uc009ahd.1 uc009ahd.2 uc009ahd.3 Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (By similarity). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9240432). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (By similarity). Homodimer or heterodimer (By similarity). It can form high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3 (PubMed:9240432). Q61827; P97302: Bach1; NbExp=5; IntAct=EBI-15740843, EBI-2552417; Nucleus. Highly expressed in heart, skeletal muscle and placenta. Also expressed in erythroid cells. Belongs to the bZIP family. Maf subfamily. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription cofactor binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated nervous system development sequence-specific DNA binding RING-like zinc finger domain binding uc009ahd.1 uc009ahd.2 uc009ahd.3 
ENSMUST00000018311.5 Stard3 ENSMUST00000018311.5 StAR related lipid transfer domain containing 3, transcript variant 7 (from RefSeq NR_189334.1) ENSMUST00000018311.1 ENSMUST00000018311.2 ENSMUST00000018311.3 ENSMUST00000018311.4 Es64 Mln64 NR_189334 Q61542 STAR3_MOUSE Stard3 uc007lgc.1 uc007lgc.2 uc007lgc.3 uc007lgc.4 Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes. The sterol transport mechanism is triggered by phosphorylation of FFAT motif that leads to membrane tethering between the endoplasmic reticulum and late endosomes via interaction with VAPA and VAPB. Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes. May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane. However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes. Does not activate transcriptional cholesterol sensing. Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina. Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747, ChEBI:CHEBI:16113; Evidence=; Homodimer. Interacts (via the MENTAL domain) with STARD3NL. Interacts (via phosphorylated FFAT motif) with VAPA (via MSP domain). Interacts (via phosphorylated FFAT motif) with VAPB (via MSP domain). Interacts (via phosphorylated FFAT motif) with MOSPD2 (via MSP domain); this interaction allows enrichment of MOSPD2 around endosomes. Late endosome membrane ; Multi-pass membrane protein Note=Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA, VAPB or MOSPD2. The FFAT motif mediates interaction with VAPA, VAPB and MOSPD2. The START domain mediates lipid-transfer between membranes. It contains a hydrophobic cavity able to accommodate one lipid molecule, thereby serving as a 'hydrophobic bridge' across the aqueous gap between donor and acceptor organelle membranes. The MENTAL domain anchors the protein in endosome membranes and exposes the START domain in the cytosol. It binds cholesterol and mediates homotypic as well as heterotypic interactions between STARD3 and STARD3NL. Phosphorylation at Ser-210 is necessary and sufficient for the direct interaction of the phosphorylated FFAT motif with the MSP domain of MOSPD2, VAPA and VAPB and allows the tethering of two membranes that participates in the formation of ER-endosome contacts. Phosphorylation of the FFAT motif leads to conformation changes. Additional phosphorylations around the core FFAT motif (QFYSPPE) are not essential but strengthen the interaction with MOSPD2, VAPA and VAPB. Phosphorylation at Ser-210 of FFAT motif drives membrane tethering between the endoplasmic reticulum and late endosomes via interaction with VAPA and VAPB that in turn allows the efficient transport of sterol mediated by the START domain. Belongs to the STARD3 family. cytoplasm mitochondrion endosome late endosome endoplasmic reticulum membrane progesterone biosynthetic process lipid transport lipid binding cholesterol binding membrane integral component of membrane cholesterol transport late endosome membrane protein homodimerization activity organelle membrane contact site vesicle tethering to endoplasmic reticulum uc007lgc.1 uc007lgc.2 uc007lgc.3 uc007lgc.4 
ENSMUST00000018313.6 Mfng ENSMUST00000018313.6 MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, transcript variant 8 (from RefSeq NR_177242.1) ENSMUST00000018313.1 ENSMUST00000018313.2 ENSMUST00000018313.3 ENSMUST00000018313.4 ENSMUST00000018313.5 Mfng NR_177242 Q3UPI0 Q3UPI0_MOUSE uc007wri.1 uc007wri.2 uc007wri.3 Reaction=3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP- N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl- (1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:70511, Rhea:RHEA-COMP:17919, Rhea:RHEA- COMP:17920, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:189632, ChEBI:CHEBI:189633; EC=2.4.1.222; Evidence= Reaction=3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl- (1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:70531, Rhea:RHEA-COMP:17922, Rhea:RHEA- COMP:17923, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:189631, ChEBI:CHEBI:189634; EC=2.4.1.222; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= Golgi apparatus membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 31 family. Golgi membrane Golgi apparatus pattern specification process membrane transferase activity transferase activity, transferring glycosyl groups integral component of Golgi membrane O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity metal ion binding uc007wri.1 uc007wri.2 uc007wri.3 
ENSMUST00000018315.10 Vmp1 ENSMUST00000018315.10 vacuole membrane protein 1, transcript variant 1 (from RefSeq NM_029478.6) A2V655 ENSMUST00000018315.1 ENSMUST00000018315.2 ENSMUST00000018315.3 ENSMUST00000018315.4 ENSMUST00000018315.5 ENSMUST00000018315.6 ENSMUST00000018315.7 ENSMUST00000018315.8 ENSMUST00000018315.9 NM_029478 Q3TX07 Q8BHD3 Q99KU0 VMP1_MOUSE Vmp1 uc007ksv.1 uc007ksv.2 uc007ksv.3 Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (By similarity). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (By similarity). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:17940279, PubMed:28890335). Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation (By similarity). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Modulates ER contacts with lipid droplets, mitochondria and endosomes (By similarity). Plays an essential role in formation of cell junctions (PubMed:31526472). Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death (By similarity). Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence=; Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747, ChEBI:CHEBI:16113; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2- diacyl-sn-glycero-3-phosphoethanolamine(out); Xref=Rhea:RHEA:38895, ChEBI:CHEBI:64612; Evidence=; Interacts with BECN1 (By similarity). Interacts with TJP1. Interacts with TP53INP2. Interacts with TMEM41B. Interacts with ATP2A2, PLN and SLN; competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2. Interacts with ATG2A (By similarity). Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Vacuole membrane ; Multi- pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain. Mutants show early embryonic lethality with lipid accumulation in the visceral endoderm (PubMed:31526472). Intestinal epithelial cell-specific knockout show accumulation of lipids in intestinal epithelial cells (PubMed:31526472). Belongs to the VMP1 family. autophagosome assembly pre-autophagosomal structure autophagosome membrane molecular_function nucleolus vacuole vacuolar membrane endoplasmic reticulum plasma membrane autophagy Golgi organization cell adhesion embryo implantation membrane integral component of membrane endoplasmic reticulum-Golgi intermediate compartment membrane cell junction assembly cell-cell adhesion uc007ksv.1 uc007ksv.2 uc007ksv.3 
ENSMUST00000018337.9 Cdc73 ENSMUST00000018337.9 cell division cycle 73, Paf1/RNA polymerase II complex component (from RefSeq NM_145991.2) CDC73_MOUSE ENSMUST00000018337.1 ENSMUST00000018337.2 ENSMUST00000018337.3 ENSMUST00000018337.4 ENSMUST00000018337.5 ENSMUST00000018337.6 ENSMUST00000018337.7 ENSMUST00000018337.8 NM_145991 Q8JZM7 uc007cwx.1 uc007cwx.2 uc007cwx.3 uc007cwx.4 Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors (By similarity). Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and SKIC8. The PAF1 complex interacts with PHF5A (PubMed:27749823). Within the PAF1 complex interacts directly with PHF5A (PubMed:27749823). Interacts with POLR2A, CPSF1, CPSF4, CSTF2, KMT2A/MLL1 and CTNNB1. Interacts with a Set1-like complex that has histone methyltransferase activity and methylates histone H3. Found in a complex with BCL9L or BCL9, CDC73, CTNNB1 and PYGO1 indicative for the participation in a nuclear Wnt signaling complex. Interacts with PTPN11 (By similarity). Interacts with SETD5 (PubMed:27864380). Nucleus Found in the adrenal gland, kidney, heart, ovary and liver. Phosphorylated. Dephosphorylated by PTPN11. Belongs to the CDC73 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core binding regulation of cell growth endodermal cell fate commitment protein binding nucleus cytosol regulation of transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter mRNA polyadenylation cell cycle negative regulation of cell proliferation histone monoubiquitination Wnt signaling pathway histone modification Cdc73/Paf1 complex stem cell population maintenance positive regulation of Wnt signaling pathway positive regulation of mRNA 3'-end processing protein destabilization positive regulation of transcription elongation from RNA polymerase II promoter histone H2B ubiquitination recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex negative regulation of apoptotic process negative regulation of myeloid cell differentiation positive regulation of transcription from RNA polymerase II promoter negative regulation of fibroblast proliferation negative regulation of epithelial cell proliferation cellular response to lipopolysaccharide positive regulation of cell cycle G1/S phase transition negative regulation of G1/S transition of mitotic cell cycle uc007cwx.1 uc007cwx.2 uc007cwx.3 uc007cwx.4 
ENSMUST00000018353.14 Stk4 ENSMUST00000018353.14 serine/threonine kinase 4 (from RefSeq NM_021420.4) ENSMUST00000018353.1 ENSMUST00000018353.10 ENSMUST00000018353.11 ENSMUST00000018353.12 ENSMUST00000018353.13 ENSMUST00000018353.2 ENSMUST00000018353.3 ENSMUST00000018353.4 ENSMUST00000018353.5 ENSMUST00000018353.6 ENSMUST00000018353.7 ENSMUST00000018353.8 ENSMUST00000018353.9 Mst1 NM_021420 Q9JI11 STK4_MOUSE uc008ntt.1 uc008ntt.2 uc008ntt.3 Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activation also requires homodimerization and autophosphorylation of Thr-183. Activated by RASSF1 which acts by preventing its dephosphorylation (By similarity). Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RASSF1. Interacts with FOXO3. Interacts with RASSF2 (via SARAH domain). Interacts with AR, PKB/AKT1, TNNI3 and SIRT1. Interacts with MARK3 and SCRIB in the presence of DLG5 (By similarity). Interacts with DLG5 (via PDZ domain 3) (PubMed:28087714). Q9JI11; Q5EBH1: Rassf5; NbExp=3; IntAct=EBI-1181352, EBI-960530; Cytoplasm Nucleus Note=The caspase-cleaved form cycles between nucleus and cytoplasm. Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-387 by PKB/AKT1, leads to inhibition of its: kinase activity, nuclear translocation and autophosphorylation at Thr- 183. It also diminishes its cleavage by caspases and its ability to phosphorylate FOXO3 (By similarity). Proteolytically cleaved by caspase-3 during apoptosis at Asp-326 resulting in a 37 kDa form. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N). Mice show progressive hepatomegaly with a 2-fold increase in liver mass relative to total body mass at 1 month of age and a 3-fold increase by 3 months of age. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. nucleotide binding magnesium ion binding cell morphogenesis branching involved in blood vessel morphogenesis neural tube formation positive regulation of protein phosphorylation endocardium development protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol protein phosphorylation apoptotic process signal transduction central nervous system development transcription factor binding negative regulation of cell proliferation kinase activity phosphorylation nuclear body transferase activity peptidyl-serine phosphorylation signal transduction by protein phosphorylation keratinocyte differentiation positive regulation of protein binding activation of protein kinase activity macromolecular complex positive regulation of peptidyl-serine phosphorylation hippo signaling intracellular signal transduction identical protein binding protein homodimerization activity positive regulation of apoptotic process positive regulation of fat cell differentiation negative regulation of organ growth protein autophosphorylation metal ion binding protein dimerization activity neuron projection morphogenesis protein stabilization primitive hemopoiesis cell differentiation involved in embryonic placenta development regulation of cell differentiation involved in embryonic placenta development negative regulation of canonical Wnt signaling pathway hepatocyte apoptotic process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of vascular associated smooth muscle cell apoptotic process uc008ntt.1 uc008ntt.2 uc008ntt.3 
ENSMUST00000018382.7 Gdf9 ENSMUST00000018382.7 growth differentiation factor 9 (from RefSeq NM_008110.2) ENSMUST00000018382.1 ENSMUST00000018382.2 ENSMUST00000018382.3 ENSMUST00000018382.4 ENSMUST00000018382.5 ENSMUST00000018382.6 Gdf9 NM_008110 Q3UWR9 Q3UWR9_MOUSE uc007iwa.1 uc007iwa.2 uc007iwa.3 uc007iwa.4 uc007iwa.5 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Female mice that are homozygous null for this gene are sterile with impaired folliculogenesis. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052667.1, AK136145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked. Secreted Belongs to the TGF-beta family. extracellular region signal transduction growth factor activity positive regulation of cell proliferation regulation of progesterone secretion uc007iwa.1 uc007iwa.2 uc007iwa.3 uc007iwa.4 uc007iwa.5 
ENSMUST00000018383.10 Zcchc10 ENSMUST00000018383.10 zinc finger, CCHC domain containing 10 (from RefSeq NM_026479.4) ENSMUST00000018383.1 ENSMUST00000018383.2 ENSMUST00000018383.3 ENSMUST00000018383.4 ENSMUST00000018383.5 ENSMUST00000018383.6 ENSMUST00000018383.7 ENSMUST00000018383.8 ENSMUST00000018383.9 NM_026479 Q9CX48 ZCH10_MOUSE uc007ivt.1 uc007ivt.2 uc007ivt.3 molecular_function nucleic acid binding cellular_component biological_process zinc ion binding metal ion binding uc007ivt.1 uc007ivt.2 uc007ivt.3 
ENSMUST00000018389.5 Prl8a8 ENSMUST00000018389.5 prolactin family 8, subfamily a, member 81, transcript variant 2 (from RefSeq NM_023741.3) ENSMUST00000018389.1 ENSMUST00000018389.2 ENSMUST00000018389.3 ENSMUST00000018389.4 NM_023741 PR8A8_MOUSE Prlpc3 Q8VHE8 Q9DAS4 uc007pxr.1 uc007pxr.2 uc007pxr.3 uc007pxr.4 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DAS4-1; Sequence=Displayed; Name=2; IsoId=Q9DAS4-2; Sequence=VSP_016781; Expressed specifically in the placenta. Predominantly expressed in spongiotrophoblast cells. Increases in abundance as gestation advanced. Predominandtly expressed in the junctional zone during the latter third of gestation. Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pxr.1 uc007pxr.2 uc007pxr.3 uc007pxr.4 
ENSMUST00000018392.9 Prl8a6 ENSMUST00000018392.9 prolactin family 8, subfamily a, member 6, transcript variant 4 (from RefSeq NR_073166.1) ENSMUST00000018392.1 ENSMUST00000018392.2 ENSMUST00000018392.3 ENSMUST00000018392.4 ENSMUST00000018392.5 ENSMUST00000018392.6 ENSMUST00000018392.7 ENSMUST00000018392.8 NR_073166 PR8A6_MOUSE Prlpc Prlpc1 Q9DAW0 Q9DAY2 Q9Z249 uc007pxo.1 uc007pxo.2 uc007pxo.3 uc007pxo.4 Secreted Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DAY2-1; Sequence=Displayed; Name=2; IsoId=Q9DAY2-2; Sequence=VSP_016904; Name=3; IsoId=Q9DAY2-3; Sequence=VSP_016903; Expressed specifically in the spongiotrophoblast and trophoblast giant cells from the junctional zone of the chorioallantoic placenta. Expression increased from midgestation to the end of the pregnancy. Belongs to the somatotropin/prolactin family. receptor binding prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pxo.1 uc007pxo.2 uc007pxo.3 uc007pxo.4 
ENSMUST00000018399.3 Krt33a ENSMUST00000018399.3 keratin 33A (from RefSeq NM_027983.3) ENSMUST00000018399.1 ENSMUST00000018399.2 KT33A_MOUSE Krt33a NM_027983 Q8K0Y2 Q9D7C4 uc007lka.1 uc007lka.2 uc007lka.3 uc007lka.4 There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). Belongs to the intermediate filament family. structural molecule activity protein binding intermediate filament biological_process uc007lka.1 uc007lka.2 uc007lka.3 uc007lka.4 
ENSMUST00000018403.8 Prl8a2 ENSMUST00000018403.8 prolactin family 8, subfamily a, member 2, transcript variant 1 (from RefSeq NM_010088.2) Dtprp ENSMUST00000018403.1 ENSMUST00000018403.2 ENSMUST00000018403.3 ENSMUST00000018403.4 ENSMUST00000018403.5 ENSMUST00000018403.6 ENSMUST00000018403.7 Ghd11 NM_010088 O54832 O54832_MOUSE Prl8a2 dPRP uc007pxl.1 uc007pxl.2 uc007pxl.3 uc007pxl.4 Secreted Belongs to the somatotropin/prolactin family. response to hypoxia prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade maternal process involved in female pregnancy positive regulation of lactation uc007pxl.1 uc007pxl.2 uc007pxl.3 uc007pxl.4 
ENSMUST00000018407.10 Tbx5 ENSMUST00000018407.10 T-box 5 (from RefSeq NM_011537.3) ENSMUST00000018407.1 ENSMUST00000018407.2 ENSMUST00000018407.3 ENSMUST00000018407.4 ENSMUST00000018407.5 ENSMUST00000018407.6 ENSMUST00000018407.7 ENSMUST00000018407.8 ENSMUST00000018407.9 NM_011537 Q5CZX7 Q5CZX7_MOUSE Tbx5 uc008zgz.1 uc008zgz.2 uc008zgz.3 uc008zgz.4 Nucleus Lacks conserved residue(s) required for the propagation of feature annotation. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated cell-cell signaling heart development transcription factor binding negative regulation of cell proliferation embryonic limb morphogenesis negative regulation of cell migration macromolecular complex protein-DNA complex embryonic forelimb morphogenesis forelimb morphogenesis sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of cardioblast differentiation pericardium development negative regulation of cardiac muscle cell proliferation uc008zgz.1 uc008zgz.2 uc008zgz.3 uc008zgz.4 
ENSMUST00000018429.12 Pld2 ENSMUST00000018429.12 phospholipase D2, transcript variant 2 (from RefSeq NM_008876.3) ENSMUST00000018429.1 ENSMUST00000018429.10 ENSMUST00000018429.11 ENSMUST00000018429.2 ENSMUST00000018429.3 ENSMUST00000018429.4 ENSMUST00000018429.5 ENSMUST00000018429.6 ENSMUST00000018429.7 ENSMUST00000018429.8 ENSMUST00000018429.9 NM_008876 Pld2 Q5SXG5 Q5SXG5_MOUSE uc007jvg.1 uc007jvg.2 uc007jvg.3 uc007jvg.4 This gene is a member of the phospholipase D (PLD) superfamily. The encoded protein catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. Phosphatidic acid is an essential intracellular lipid second messenger for many signaling pathways and has been implicated in a variety of physiological processes including cytoskeletal organization and cell proliferation. A similar gene in human may also function as a guanine nucleotide exchange factor (GEF) for the small GTPase Rac2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl- sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=3.1.4.4; Evidence=; Belongs to the phospholipase D family. catalytic activity phospholipase D activity phosphatidic acid biosynthetic process lipid catabolic process hydrolase activity phosphatidylinositol binding inositol lipid-mediated signaling N-acylphosphatidylethanolamine-specific phospholipase D activity uc007jvg.1 uc007jvg.2 uc007jvg.3 uc007jvg.4 
ENSMUST00000018430.7 Psmb6 ENSMUST00000018430.7 proteasome (prosome, macropain) subunit, beta type 6 (from RefSeq NM_008946.4) ENSMUST00000018430.1 ENSMUST00000018430.2 ENSMUST00000018430.3 ENSMUST00000018430.4 ENSMUST00000018430.5 ENSMUST00000018430.6 Lmp19 NM_008946 PSB6_MOUSE Q3V240 Q60692 Q60693 Q8BJX9 Q91VH5 uc007jve.1 uc007jve.2 uc007jve.3 uc007jve.4 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues. Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; Evidence=; The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Cytoplasm Nucleus Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. Up-regulated by the antioxidant dithiolethione (D3T) in liver, lung and small intestine (at protein level). Belongs to the peptidase T1B family. Sequence=AAA75375.1; Type=Erroneous initiation; Evidence=; Sequence=AAA75376.1; Type=Erroneous initiation; Evidence=; Sequence=AAH13897.1; Type=Erroneous initiation; Evidence=; Sequence=BAE20959.1; Type=Frameshift; Evidence=; proteasome complex endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteolysis peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, beta-subunit complex proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process uc007jve.1 uc007jve.2 uc007jve.3 uc007jve.4 
ENSMUST00000018431.13 Spag7 ENSMUST00000018431.13 sperm associated antigen 7, transcript variant 1 (from RefSeq NM_172561.3) ENSMUST00000018431.1 ENSMUST00000018431.10 ENSMUST00000018431.11 ENSMUST00000018431.12 ENSMUST00000018431.2 ENSMUST00000018431.3 ENSMUST00000018431.4 ENSMUST00000018431.5 ENSMUST00000018431.6 ENSMUST00000018431.7 ENSMUST00000018431.8 ENSMUST00000018431.9 NM_172561 Q3TM27 Q7TNE3 Q80XJ8 Q8BK16 SPAG7_MOUSE uc007jvz.1 uc007jvz.2 uc007jvz.3 uc007jvz.4 Nucleus molecular_function nucleic acid binding nucleus biological_process uc007jvz.1 uc007jvz.2 uc007jvz.3 uc007jvz.4 
ENSMUST00000018437.3 Pfn1 ENSMUST00000018437.3 profilin 1 (from RefSeq NM_011072.4) ENSMUST00000018437.1 ENSMUST00000018437.2 NM_011072 Pfn1 Q5SX50 Q5SX50_MOUSE uc007jvv.1 uc007jvv.2 uc007jvv.3 uc007jvv.4 Belongs to the profilin family. adenyl-nucleotide exchange factor activity actin binding actin monomer binding receptor binding phosphatidylinositol-4,5-bisphosphate binding nucleus cytoplasm cell cortex response to organic substance positive regulation of epithelial cell migration actin cytoskeleton organization negative regulation of actin filament polymerization positive regulation of actin filament polymerization negative regulation of actin filament bundle assembly positive regulation of ATPase activity neuron projection synapse positive regulation of transcription from RNA polymerase II promoter positive regulation of viral transcription protein stabilization positive regulation of DNA metabolic process positive regulation of stress fiber assembly negative regulation of stress fiber assembly proline-rich region binding cellular response to growth factor stimulus presynapse postsynapse positive regulation of ruffle assembly uc007jvv.1 uc007jvv.2 uc007jvv.3 uc007jvv.4 
ENSMUST00000018449.11 Prpf8 ENSMUST00000018449.11 pre-mRNA processing factor 8 (from RefSeq NM_138659.2) A5D6Q4 ENSMUST00000018449.1 ENSMUST00000018449.10 ENSMUST00000018449.2 ENSMUST00000018449.3 ENSMUST00000018449.4 ENSMUST00000018449.5 ENSMUST00000018449.6 ENSMUST00000018449.7 ENSMUST00000018449.8 ENSMUST00000018449.9 NM_138659 PRP8_MOUSE Prp8 Q5ND30 Q5ND31 Q7TQK2 Q8BRZ5 Q8K001 Q99PV0 uc007kdx.1 uc007kdx.2 uc007kdx.3 Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. Part of the U5 snRNP complex (By similarity). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39 (By similarity). Component of the U5.U4atac/U6atac snRNP complexes in U12-dependent spliceosomes (By similarity). Within the minor spliceosome, which acts on U12-type introns, interacts with PPIL2 and RBM48 (By similarity). Core component of U2-type precatalytic, catalytic and postcatalytic spliceosomal complexes (By similarity). Found in a mRNA splicing- dependent exon junction complex (EJC) with SRRM1 (By similarity). Interacts with U5 snRNP proteins SNRP116 and SNRNP40 (By similarity). Interacts with EFTUD2 (By similarity). Interacts (via the MPN (JAB/Mov34) domain) with PRPF3 ('Lys-63'-linked polyubiquitinated); may stabilize the U4/U6-U5 tri-snRNP complex (By similarity). Interacts (via RNase H homology domain) with AAR2 (By similarity). Interacts with RPAP3 and URI1 in a ZNHIT2-dependent manner (By similarity). Interacts with C9orf78 (By similarity). Interacts with SNRNP200 (By similarity). Interacts with TSSC4; the interaction is direct (By similarity). Nucleus Nucleus speckle Strongly expressed in testis (preferentially in the outer cell layer), and moderately in ovary (preferentially in granulosa cells). During embryogenesis, is highly expressed at day 9.5 of gestation, and its expression decreases progressively during embryogenesis. The MPN (JAB/Mov34) domain has structural similarity with deubiquitinating enzymes, but lacks the residues that would bind the catalytic metal ion. Contains a region with structural similarity to reverse transcripase, presenting the classical thumb, fingers and palm architecture, but lacks enzyme activity, since the essential metal- binding residues are not conserved. Contains a region with structural similarity to type-2 restriction endonucleases, but the residues that would bind catalytic metal ions in endonucleases are instead involved in hydrogen bonds that stabilize the protein structure. Contains a region with structural similarity to RNase H, but lacks RNase H activity. The MPN (JAB/Mov34) domain mediates interaction with TSSC4 and SNRNP200. Has structural similarity with deubiquitinating enzymes, but lacks the residues that would bind the catalytic metal ion. Sequence=AAH54103.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; spliceosomal tri-snRNP complex assembly second spliceosomal transesterification activity mRNA splicing, via spliceosome RNA binding nucleus spliceosomal complex U5 snRNP mRNA processing RNA splicing nuclear speck U6 snRNA binding small nuclear ribonucleoprotein complex U1 snRNA binding U2 snRNA binding U5 snRNA binding U4/U6 x U5 tri-snRNP complex K63-linked polyubiquitin binding U2-type precatalytic spliceosome U2-type catalytic step 1 spliceosome U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome cellular response to lipopolysaccharide cellular response to tumor necrosis factor pre-mRNA intronic binding uc007kdx.1 uc007kdx.2 uc007kdx.3 
ENSMUST00000018470.10 Ywhab ENSMUST00000018470.10 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide, transcript variant 5 (from RefSeq NR_184744.1) 1433B_MOUSE ENSMUST00000018470.1 ENSMUST00000018470.2 ENSMUST00000018470.3 ENSMUST00000018470.4 ENSMUST00000018470.5 ENSMUST00000018470.6 ENSMUST00000018470.7 ENSMUST00000018470.8 ENSMUST00000018470.9 NR_184744 O70455 Q3TY33 Q3UAN6 Q9CQV8 uc008ntp.1 uc008ntp.2 uc008ntp.3 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. Homodimer (By similarity). Interacts with SAMSN1 and PRKCE (PubMed:18604201, PubMed:20478393). Interacts with AKAP13. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2. Interacts with YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with PKA- phosphorylated AANAT. Interacts with MYO1C. Interacts with SIRT2 (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B. Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (By similarity). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (By similarity). Interacts with SLITRK1 (By similarity). Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (PubMed:15883195). Interacts with RIPOR2 (via phosphorylated form); this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (By similarity). Interacts with MARK2 and MARK3 (By similarity). Interacts with TESK1; the interaction is dependent on the phosphorylation of TESK1 'Ser-439' and inhibits TESK1 kinase activity (By similarity). Interacts with MEFV (By similarity). Interacts with HDAC4 (By similarity). Interacts with ADAM22 (via C-terminus) (By similarity). Q9CQV8; Q5S006: Lrrk2; NbExp=6; IntAct=EBI-771608, EBI-2693710; Q9CQV8; P16054: Prkce; NbExp=5; IntAct=EBI-771608, EBI-298451; Q9CQV8; Q91YE8: Synpo2; NbExp=3; IntAct=EBI-771608, EBI-7623057; Cytoplasm Melanosome Event=Alternative initiation; Named isoforms=2; Name=Long; IsoId=Q9CQV8-1; Sequence=Displayed; Name=Short; IsoId=Q9CQV8-2; Sequence=VSP_018634; Isoform alpha differs from isoform beta in being phosphorylated (By similarity). Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Isoform Short contains a N-acetylmethionine at position 1. Belongs to the 14-3-3 family. protein binding nucleus cytoplasm cytosol protein targeting protein C-terminus binding transcriptional repressor complex enzyme binding protein domain specific binding macromolecular complex negative regulation of protein dephosphorylation melanosome identical protein binding histone deacetylase binding positive regulation of catalytic activity macromolecular complex binding negative regulation of G-protein coupled receptor protein signaling pathway negative regulation of transcription, DNA-templated perinuclear region of cytoplasm phosphoserine binding phosphoprotein binding cytoplasmic sequestering of protein protein heterooligomerization uc008ntp.1 uc008ntp.2 uc008ntp.3 
ENSMUST00000018476.14 Stk3 ENSMUST00000018476.14 serine/threonine kinase 3, transcript variant 1 (from RefSeq NM_019635.2) ENSMUST00000018476.1 ENSMUST00000018476.10 ENSMUST00000018476.11 ENSMUST00000018476.12 ENSMUST00000018476.13 ENSMUST00000018476.2 ENSMUST00000018476.3 ENSMUST00000018476.4 ENSMUST00000018476.5 ENSMUST00000018476.6 ENSMUST00000018476.7 ENSMUST00000018476.8 ENSMUST00000018476.9 Mess1 Mst2 NM_019635 Q60877 Q80UG4 Q8CI58 Q9JI10 STK3_MOUSE uc007vlz.1 uc007vlz.2 uc007vlz.3 Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1. Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activation also requires homodimerization and autophosphorylation of Thr-180, which are inhibited by the proto-oncogene product RAF1. Activated by RASSF1 which acts by preventing its dephosphorylation (By similarity). Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RAF1, which prevents dimerization and phosphorylation. Interacts with RASSF1. Interacts (via SARAH domain) with NEK2. Interacts with ESR1 only in the presence of SAV1. Interacts with PKB/AKT1. Forms a tripartite complex with MOBKL1B and STK38. Interacts with RASSF2 (via SARAH domain). Interacts with LATS1; this interaction is inhibited in the presence of DLG5. Interacts with MARK3 in the presence of DLG5 (By similarity). Interacts with DLG5 (via PDZ domain 3) (PubMed:28087714). Interacts with RASSF5; this interaction inhibits STK3 autoactivation through heterodimerization (By similarity). Cytoplasm Nucleus Note=The caspase-cleaved form cycles between nucleus and cytoplasm (By similarity). Phosphorylation at Thr- 117 leads to inhibition of nuclear translocation (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JI10-1; Sequence=Displayed; Name=2; IsoId=Q9JI10-2; Sequence=VSP_020047; Autophosphorylated on two residues Thr-174 and Thr-180, leading to activation. Phosphorylation at Thr-117 and Thr-390 by PKB/AKT1, leads to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation, and increase in its binding to RAF1. Phosphorylated at Ser-15 by PLK1, leading to activation. Proteolytically cleaved by caspase-3 during apoptosis. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N). Ubiquitinated by TRIM69; leading to its redistribution to the perinuclear cytoskeleton. Mice show progressive hepatomegaly with a 2-fold increase in liver mass relative to total body mass at 1 month of age and a 3-fold increase by 3 months of age. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Sequence=AAA75300.1; Type=Frameshift; Evidence=; nucleotide binding magnesium ion binding neural tube formation endocardium development protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm protein phosphorylation apoptotic process signal transduction central nervous system development negative regulation of cell proliferation kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation positive regulation of protein binding activation of protein kinase activity macromolecular complex hippo signaling intracellular signal transduction identical protein binding positive regulation of apoptotic process positive regulation of fat cell differentiation positive regulation of JNK cascade negative regulation of organ growth metal ion binding protein dimerization activity neuron projection morphogenesis protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of protein kinase B signaling primitive hemopoiesis cell differentiation involved in embryonic placenta development regulation of cell differentiation involved in embryonic placenta development negative regulation of canonical Wnt signaling pathway hepatocyte apoptotic process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors uc007vlz.1 uc007vlz.2 uc007vlz.3 
ENSMUST00000018478.11 Ksr1 ENSMUST00000018478.11 kinase suppressor of ras 1, transcript variant 1 (from RefSeq NM_013571.3) ENSMUST00000018478.1 ENSMUST00000018478.10 ENSMUST00000018478.2 ENSMUST00000018478.3 ENSMUST00000018478.4 ENSMUST00000018478.5 ENSMUST00000018478.6 ENSMUST00000018478.7 ENSMUST00000018478.8 ENSMUST00000018478.9 KSR1_MOUSE Ksr NM_013571 Q61097 Q61648 Q78DX8 uc033fyp.1 uc033fyp.2 uc033fyp.3 Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (PubMed:10409742, PubMed:12932319, PubMed:21102438, PubMed:21441104). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (By similarity). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (PubMed:21102438). Its kinase activity is unsure (PubMed:21441104). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (PubMed:21441104). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Homodimer (By similarity). Heterodimerizes (via N-terminus) with BRAF (via N-terminus) in a MAP2K1/MEK1 or MAP2K2/MEK2-dependent manner (By similarity). Interacts with MAP2K1/MEK1 and MAP2K2/MEK2 (PubMed:10891492, PubMed:10409742, PubMed:21441104). Binding to MAP2K1/MEK1 releases the intramolecular inhibitory interaction between KSR1 N-terminus and kinase domains which is required for the subsequent RSK1 dimerization with BRAF (By similarity). Identified in a complex with AKAP13, MAP2K1 and BRAF (PubMed:21102438, PubMed:23250398). Interacts with AKAP13 and BRAF (PubMed:21102438). Interacts with RAF and MAPK/ERK, in a Ras-dependent manner (PubMed:10891492). Interacts with 14-3-3 proteins including YWHAB (PubMed:10409742, PubMed:11741534). Interacts with HSP90AA1/HSP90, YWHAE/14-3-3 and CDC37 (PubMed:10409742). The binding of 14-3-3 proteins to phosphorylated KSR1 prevents the membrane localization (PubMed:10409742). Interacts with MARK3/C-TAK1 (PubMed:11741534, PubMed:12941695). Interacts with PPP2R1A and PPP2CA (PubMed:12932319). Interacts with VRK2 (By similarity). Q61097; Q60875: Arhgef2; NbExp=5; IntAct=EBI-1536336, EBI-772191; Q61097; P15056: BRAF; Xeno; NbExp=3; IntAct=EBI-1536336, EBI-365980; Q61097; P15531: NME1; Xeno; NbExp=7; IntAct=EBI-1536336, EBI-741141; Q61097; Q86Y07-1: VRK2; Xeno; NbExp=8; IntAct=EBI-1536336, EBI-1207633; Cytoplasm mbrane ; Peripheral membrane protein Cell membrane eripheral membrane protein ll projection, ruffle membrane Endoplasmic reticulum membrane Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61097-1; Sequence=Displayed; Name=2; Synonyms=B-KSR1; IsoId=Q61097-2; Sequence=VSP_012232, VSP_012233; Expressed in brain, spleen and testis. Isoform 1 is highly expressed spleen and weakly in testis, and isoform 2 is highly expressed in brain and weakly in testis. The protein kinase domain is predicted to be catalytically inactive. The domain is sufficient for KSR1 and KSR1-mediated MAP2K1 and MAP2K2 membrane localization. The domain is required but not sufficient for MAP kinase-mediated inhibition of ELK1 phosphorylation (PubMed:10409742). The N-terminal region mediates interaction with BRAF (PubMed:23250398). Also mediates membrane localization (PubMed:23250398). Phosphorylated on Ser-297 and, to a higher extent, on Ser-392 by MARK3 (PubMed:11741534, PubMed:12941695). Dephosphorylated on Ser-392 by PPP2CA (PubMed:12932319). Phosphorylated KSR1 is cytoplasmic and dephosphorylated KSR1 is membrane-associated (Probable). Phosphorylated by PKA at Ser-838. Phosphorylation at Ser-838 is required for cAMP- dependent activation of MAPK1 and/or MAPK3 (PubMed:21102438). Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Although it belongs to the protein kinase superfamily, the ATP-binding motif VAIK has an arginine instead of a lysine residue suggesting that KSR1 cannot bind ATP and therefore lacks protein kinase activity. However, KSR1 is capable of binding ATP (PubMed:21441104). Has protein kinase activity towards MAP2K1 in presence of RAF1/c-RAF in vitro (PubMed:21441104). activation of MAPKKK activity protein kinase activity MAP-kinase scaffold activity protein binding ATP binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane protein phosphorylation Ras protein signal transduction protein C-terminus binding membrane protein kinase binding cAMP-mediated signaling mitogen-activated protein kinase kinase binding ruffle membrane macromolecular complex intracellular signal transduction regulation of cell proliferation cell projection regulation of MAP kinase activity positive regulation of MAPK cascade metal ion binding protein heterodimerization activity chaperone binding Hsp90 protein binding 14-3-3 protein binding uc033fyp.1 uc033fyp.2 uc033fyp.3 
ENSMUST00000018485.4 Il12rb2 ENSMUST00000018485.4 interleukin 12 receptor, beta 2, transcript variant 1 (from RefSeq NM_008354.4) B9EHD9 ENSMUST00000018485.1 ENSMUST00000018485.2 ENSMUST00000018485.3 I12R2_MOUSE NM_008354 P97378 uc009cfo.1 uc009cfo.2 uc009cfo.3 Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. Can also activate STAT3. Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain (By similarity). P97378; Q99KY4: Gak; NbExp=7; IntAct=EBI-6253448, EBI-7652906; Membrane; Single-pass type I membrane protein. Expressed in developing T-helper (TH) cells. Expressed at high levels in Th1 cells on day 3, 5 and 7 after primary activation. Very low expression in Th2 cells on day 3 and not detectable on day 5 nor day 7 after activation. Following T-cell activation, expression inhibited by IL4 and induced by IFN gamma. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. On IL12 stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation of any one of Tyr-757, Tyr-804 or Tyr-811 can activate STAT4, IFN-gamma production, and T-cell proliferation. Tyr-811 is the dominant site of cell proliferation. Lps-defective mice C57BL/10ScCr (Cr) mice carry a mutation in the IL12RB2 gene leading to the production of a truncated IL12 receptor beta 2 chain resulting in malfunction of the IL12- mediated IFN-gamma response. Belongs to the type I cytokine receptor family. Type 2 subfamily. cytokine receptor activity protein binding plasma membrane external side of plasma membrane membrane integral component of membrane peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway protein kinase binding cytokine binding response to lipopolysaccharide interferon-gamma production positive regulation of interferon-gamma production response to cytokine receptor complex uc009cfo.1 uc009cfo.2 uc009cfo.3 
ENSMUST00000018506.13 Kpna2 ENSMUST00000018506.13 karyopherin subunit alpha 2 (from RefSeq NM_010655.3) ENSMUST00000018506.1 ENSMUST00000018506.10 ENSMUST00000018506.11 ENSMUST00000018506.12 ENSMUST00000018506.2 ENSMUST00000018506.3 ENSMUST00000018506.4 ENSMUST00000018506.5 ENSMUST00000018506.6 ENSMUST00000018506.7 ENSMUST00000018506.8 ENSMUST00000018506.9 Kpna2 NM_010655 Q52L97 Q52L97_MOUSE uc007lzz.1 uc007lzz.2 uc007lzz.3 Functions in nuclear protein import. Belongs to the importin alpha family. nucleus cytoplasm protein import into nucleus protein transport nuclear import signal receptor activity uc007lzz.1 uc007lzz.2 uc007lzz.3 
ENSMUST00000018516.11 Cep95 ENSMUST00000018516.11 centrosomal protein 95, transcript variant 1 (from RefSeq NM_177088.3) A2A5Z8 CEP95_MOUSE Ccdc45 ENSMUST00000018516.1 ENSMUST00000018516.10 ENSMUST00000018516.2 ENSMUST00000018516.3 ENSMUST00000018516.4 ENSMUST00000018516.5 ENSMUST00000018516.6 ENSMUST00000018516.7 ENSMUST00000018516.8 ENSMUST00000018516.9 NM_177088 Q8BVV7 uc007lzu.1 uc007lzu.2 uc007lzu.3 uc007lzu.4 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole spindle pole molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton biological_process uc007lzu.1 uc007lzu.2 uc007lzu.3 uc007lzu.4 
ENSMUST00000018521.11 Vezf1 ENSMUST00000018521.11 vascular endothelial zinc finger 1, transcript variant 1 (from RefSeq NM_016686.5) ENSMUST00000018521.1 ENSMUST00000018521.10 ENSMUST00000018521.2 ENSMUST00000018521.3 ENSMUST00000018521.4 ENSMUST00000018521.5 ENSMUST00000018521.6 ENSMUST00000018521.7 ENSMUST00000018521.8 ENSMUST00000018521.9 NM_016686 Q5SXC4 Q5SXC4_MOUSE Vezf1 uc007kvf.1 uc007kvf.2 uc007kvf.3 RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis endothelial cell development nucleic acid binding nucleus nucleoplasm positive regulation of endothelial cell differentiation positive regulation of transcription from RNA polymerase II promoter uc007kvf.1 uc007kvf.2 uc007kvf.3 
ENSMUST00000018522.13 Cuedc1 ENSMUST00000018522.13 CUE domain containing 1, transcript variant 1 (from RefSeq NM_198013.3) CUED1_MOUSE ENSMUST00000018522.1 ENSMUST00000018522.10 ENSMUST00000018522.11 ENSMUST00000018522.12 ENSMUST00000018522.2 ENSMUST00000018522.3 ENSMUST00000018522.4 ENSMUST00000018522.5 ENSMUST00000018522.6 ENSMUST00000018522.7 ENSMUST00000018522.8 ENSMUST00000018522.9 NM_198013 Q5SXC2 Q8R3V6 uc007kvh.1 uc007kvh.2 uc007kvh.3 molecular_function cellular_component biological_process uc007kvh.1 uc007kvh.2 uc007kvh.3 
ENSMUST00000018549.8 Mrm1 ENSMUST00000018549.8 mitochondrial rRNA methyltransferase 1 (from RefSeq NM_145433.1) ENSMUST00000018549.1 ENSMUST00000018549.2 ENSMUST00000018549.3 ENSMUST00000018549.4 ENSMUST00000018549.5 ENSMUST00000018549.6 ENSMUST00000018549.7 MRM1_MOUSE Mrm1 NM_145433 Q3TPX8 Q3U0Z5 Q5ND22 Q99J25 uc007kqr.1 uc007kqr.2 S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Reaction=guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine = 2'-O- methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:47776, Rhea:RHEA-COMP:11909, Rhea:RHEA-COMP:11910, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74445; Evidence=; Mitochondrion matrix Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. Sequence=BAE33706.1; Type=Frameshift; Evidence=; rRNA 2'-O-methylation RNA methylation RNA binding mitochondrion rRNA processing RNA processing methyltransferase activity RNA methyltransferase activity transferase activity methylation rRNA (guanosine-2'-O-)-methyltransferase activity uc007kqr.1 uc007kqr.2 
ENSMUST00000018561.14 Myo1b ENSMUST00000018561.14 myosin IB, transcript variant 5 (from RefSeq NM_001420363.1) ENSMUST00000018561.1 ENSMUST00000018561.10 ENSMUST00000018561.11 ENSMUST00000018561.12 ENSMUST00000018561.13 ENSMUST00000018561.2 ENSMUST00000018561.3 ENSMUST00000018561.4 ENSMUST00000018561.5 ENSMUST00000018561.6 ENSMUST00000018561.7 ENSMUST00000018561.8 ENSMUST00000018561.9 Myo1b NM_001420363 Q7TQD7 Q7TQD7_MOUSE uc007axs.1 uc007axs.2 uc007axs.3 uc007axs.4 uc007axs.5 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. microfilament motor activity nucleotide binding motor activity actin binding ATP binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm early endosome actin filament plasma membrane brush border post-Golgi vesicle-mediated transport actin filament organization endosome membrane myosin complex actin filament-based movement filopodium actin-dependent ATPase activity trans-Golgi network membrane apical part of cell perinuclear region of cytoplasm actin filament binding actin filament bundle assembly cell periphery uc007axs.1 uc007axs.2 uc007axs.3 uc007axs.4 uc007axs.5 
ENSMUST00000018568.4 Drg2 ENSMUST00000018568.4 developmentally regulated GTP binding protein 2, transcript variant 2 (from RefSeq NR_184453.1) DRG2_MOUSE ENSMUST00000018568.1 ENSMUST00000018568.2 ENSMUST00000018568.3 NR_184453 Q5SX94 Q9QXB9 uc007jfy.1 uc007jfy.2 uc007jfy.3 Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with RWDD1; this interaction confers protection to polyubiquitination and proteolytic degradation (PubMed:15676025). Interacts with JMJD7; this interaction is direct (By similarity). Nucleus Cytoplasm Fairly high levels in liver, heart, kidney, and brain. Very low levels in lung, spleen, testis and skeletal muscle. Polyubiquitinated. Hydroxylated (with S stereochemistry) at C-3 of Lys-21 by JMJD7. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. nucleotide binding cytoplasmic translation RNA binding GTPase activity GTP binding nucleus nucleoplasm cytoplasm mitochondrion cytosol hydrolase activity intracellular membrane-bounded organelle metal ion binding uc007jfy.1 uc007jfy.2 uc007jfy.3 
ENSMUST00000018569.14 Dhx40 ENSMUST00000018569.14 DEAH-box helicase 40 (from RefSeq NM_026191.2) DHX40_MOUSE ENSMUST00000018569.1 ENSMUST00000018569.10 ENSMUST00000018569.11 ENSMUST00000018569.12 ENSMUST00000018569.13 ENSMUST00000018569.2 ENSMUST00000018569.3 ENSMUST00000018569.4 ENSMUST00000018569.5 ENSMUST00000018569.6 ENSMUST00000018569.7 ENSMUST00000018569.8 ENSMUST00000018569.9 NM_026191 Q6PE54 Q8BPH2 Q8CD88 Q9CWN3 uc007ktc.1 uc007ktc.2 uc007ktc.3 Probable ATP-dependent RNA helicase. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Belongs to the DEAD box helicase family. DEAH subfamily. Sequence=AAH58276.2; Type=Erroneous initiation; Evidence=; Sequence=BAB26995.2; Type=Erroneous initiation; Evidence=; Sequence=BAC25091.1; Type=Frameshift; Evidence=; Sequence=BAC27210.1; Type=Frameshift; Evidence=; Sequence=BAC36102.1; Type=Frameshift; Evidence=; nucleotide binding mRNA splicing, via spliceosome nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding hydrolase activity uc007ktc.1 uc007ktc.2 uc007ktc.3 
ENSMUST00000018571.5 Ypel2 ENSMUST00000018571.5 yippee like 2 (from RefSeq NM_001005341.3) ENSMUST00000018571.1 ENSMUST00000018571.2 ENSMUST00000018571.3 ENSMUST00000018571.4 NM_001005341 Q65Z95 YPEL2_MOUSE uc007ktd.1 uc007ktd.2 uc007ktd.3 May interact with FAM168B. Nucleus, nucleolus Detected in testis, heart, brain, spleen, lung and liver. Belongs to the yippee family. molecular_function cellular_component nucleus nucleolus biological_process metal ion binding uc007ktd.1 uc007ktd.2 uc007ktd.3 
ENSMUST00000018572.11 Akap1 ENSMUST00000018572.11 A kinase anchor protein 1, transcript variant 2 (from RefSeq NM_001042541.1) AKAP1_MOUSE Akap Akap1 B1AR25 ENSMUST00000018572.1 ENSMUST00000018572.10 ENSMUST00000018572.2 ENSMUST00000018572.3 ENSMUST00000018572.4 ENSMUST00000018572.5 ENSMUST00000018572.6 ENSMUST00000018572.7 ENSMUST00000018572.8 ENSMUST00000018572.9 NM_001042541 O08714 O08715 P97488 uc007kvw.1 uc007kvw.2 Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A (PubMed:9065479, PubMed:9182549). Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum (PubMed:9065479, PubMed:9182549). Involved in mitochondrial-mediated antiviral innate immunity (By similarity). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (PubMed:32072193). Under diabetic conditions, myocardial AKAP1 expression decreases which blocks the translocation of NDUFS1 from the cytosol to mitochondria (PubMed:32072193). Reduction of NDUFS1 in mitochondria decreases ATP production and increases mitochondrial ROS level, which causes mitochondrial dysfunction and cell apoptosis, respectively, thereby leading to cardiac dysfunction (PubMed:32072193). Interacts with SLC8A3 (PubMed:24101730). Interacts with CFAP91. Interacts with CLPB (By similarity). Interacts with NDUFS1 (PubMed:32072193). O08715; Q06986: Siah2; NbExp=6; IntAct=EBI-7838029, EBI-957413; O08715-5; Q16825: PTPN21; Xeno; NbExp=2; IntAct=EBI-9117988, EBI-2860264; Mitochondrion outer membrane Mitochondrion [Isoform 2]: Endoplasmic reticulum Note=Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 acts as a suppressor of mitochondrial targeting and as an activator of recessive endoplasmic reticulum targeting motif. [Isoform 4]: Endoplasmic reticulum Note=Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 4 acts as a suppressor of mitochondrial targeting and as an activator of recessive endoplasmic reticulum targeting motif. [Isoform 1]: Mitochondrion outer membrane Note=Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. [Isoform 3]: Mitochondrion outer membrane Note=Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. [Isoform 5]: Mitochondrion outer membrane Note=Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. [Isoform 6]: Mitochondrion outer membrane Note=Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. Event=Alternative splicing; Named isoforms=6; Name=3; Synonyms=D-AKAP1C, AKAP121; IsoId=O08715-1; Sequence=Displayed; Name=1; Synonyms=D-AKAP1A; IsoId=O08715-2; Sequence=VSP_002848, VSP_002849; Name=2; Synonyms=D-AKAP1B; IsoId=O08715-3; Sequence=VSP_002847, VSP_002848, VSP_002849; Name=4; Synonyms=D-AKAP1D; IsoId=O08715-4; Sequence=VSP_002847; Name=5; Synonyms=S-AKAP84; IsoId=O08715-5; Sequence=VSP_002850, VSP_002851; Name=6; Synonyms=AKAP100; IsoId=O08715-6; Sequence=VSP_002852, VSP_002853; Highest expression in testis, heart, liver, skeletal muscle, intestine and kidney, followed by brain and lung. No expression in spleen. Isoform 1/D-AKAP1A is expressed predominantly in testis whereas isoform 4/D-AKAP1D is expressed primarily in liver (PubMed:9065479). Expression is decreased in hearts of diabetic mice (at protein level) (PubMed:32072193). RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. Knockout in diabetogenic agent streptozotocin- treated mice results in significant cardiac dysfunction which is accompanied by impaired mitochondrial function and increased cardiomyocyte apoptosis. nucleic acid binding RNA binding protein binding mitochondrion mitochondrial outer membrane endoplasmic reticulum lipid particle microtubule binding negative regulation of cardiac muscle hypertrophy regulation of protein kinase A signaling membrane integral component of membrane protein kinase binding protein phosphatase binding mitochondrial crista protein phosphatase 2B binding neuromuscular junction protein kinase A regulatory subunit binding negative regulation of protein dephosphorylation negative regulation of protein import into nucleus postsynaptic membrane beta-tubulin binding binding, bridging uc007kvw.1 uc007kvw.2 
ENSMUST00000018577.8 Nol11 ENSMUST00000018577.8 nucleolar protein 11, transcript variant 4 (from RefSeq NR_156439.1) ENSMUST00000018577.1 ENSMUST00000018577.2 ENSMUST00000018577.3 ENSMUST00000018577.4 ENSMUST00000018577.5 ENSMUST00000018577.6 ENSMUST00000018577.7 NOL11_MOUSE NR_156439 Q8BGJ1 Q8BJW5 Q8R3Q3 Q99KA5 uc007mai.1 uc007mai.2 uc007mai.3 uc007mai.4 uc007mai.5 Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b (By similarity). Interacts with UTP4. Interacts with FBL/fibrillarin in a transcription-dependent manner. May associate with the proposed t-UTP subcomplex of the SSU processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75. Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BJW5-1; Sequence=Displayed; Name=2; IsoId=Q8BJW5-2; Sequence=VSP_015459; [Isoform 2]: May be due to a competing acceptor splice site. nucleus nucleolus rRNA processing maturation of SSU-rRNA t-UTP complex ribosome biogenesis positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter uc007mai.1 uc007mai.2 uc007mai.3 uc007mai.4 uc007mai.5 
ENSMUST00000018593.10 Rpain ENSMUST00000018593.10 RPA interacting protein, transcript variant 5 (from RefSeq NR_156443.1) ENSMUST00000018593.1 ENSMUST00000018593.2 ENSMUST00000018593.3 ENSMUST00000018593.4 ENSMUST00000018593.5 ENSMUST00000018593.6 ENSMUST00000018593.7 ENSMUST00000018593.8 ENSMUST00000018593.9 NR_156443 Q9CWY9 RIP_MOUSE Rip uc007jxa.1 uc007jxa.2 uc007jxa.3 uc007jxa.4 Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Sumoylation mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism (By similarity). Interacts with the RPA1 subunit of RPA complex. Nucleus Sumoylated; required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues (By similarity). fibrillar center nucleus cytoplasm DNA-dependent DNA replication DNA repair DNA recombination protein import into nucleus response to UV PML body macromolecular complex binding metal ion binding uc007jxa.1 uc007jxa.2 uc007jxa.3 uc007jxa.4 
ENSMUST00000018610.7 Nos2 ENSMUST00000018610.7 nitric oxide synthase 2, inducible, transcript variant 1 (from RefSeq NM_010927.4) ENSMUST00000018610.1 ENSMUST00000018610.2 ENSMUST00000018610.3 ENSMUST00000018610.4 ENSMUST00000018610.5 ENSMUST00000018610.6 Inosl NM_010927 NOS2_MOUSE O70515 O70516 P29477 Q5SXT3 Q6P6A0 Q8R410 uc007kkc.1 uc007kkc.2 uc007kkc.3 uc007kkc.4 Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7503239). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (PubMed:16373578). As component of the iNOS- S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (By similarity). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (By similarity). Reaction=H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide; Xref=Rhea:RHEA:19897, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16480, ChEBI:CHEBI:32682, ChEBI:CHEBI:57743, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.39; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19898; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence= Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD. ; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Note=Binds 1 FMN. ; Name=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin; Xref=ChEBI:CHEBI:59560; Evidence= Note=Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme. Not stimulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity. Homodimer (PubMed:10769116, PubMed:11669619). Interacts with NHERF1 (By similarity). Interacts with GAPDH (By similarity). Interacts with S100A8 and S100A9 to form the iNOS-S100A8/9 transnitrosylase complex (By similarity). Interacts with SPSB1, SPSB2 and SPSB4 (PubMed:20603330). Interacts with ELOC and CUL5 in the presence of SPSB1 or SPSB2 or SPSB4 (By similarity). Forms a complex with ASL, ASS1 and HSP90AA1; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L- arginine to nitric oxide synthesis pathway. P29477; Q04207: Rela; NbExp=3; IntAct=EBI-298897, EBI-644400; Cytoplasm, cytosol Note=Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization. Macrophages. By treatment with endotoxins or cytokines. By lipopolysaccharides (LPS) (in vitro). Expression in the liver oscillates in a circadian manner with peak levels occurring during the late night. Polyubiquitinated; mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation. Belongs to the NOS family. response to hypoxia actin binding NADPH-hemoprotein reductase activity nitric-oxide synthase activity protein binding calmodulin binding extracellular space nucleus cytoplasm peroxisome cytosol plasma membrane arginine catabolic process superoxide metabolic process nitric oxide biosynthetic process inflammatory response nitric oxide mediated signal transduction circadian rhythm beta-catenin binding cAMP-dependent protein kinase regulator activity response to bacterium response to hormone FMN binding negative regulation of gene expression vesicle membrane oxidoreductase activity peptidyl-cysteine S-nitrosylation protein kinase binding heme binding cortical cytoskeleton positive regulation of guanylate cyclase activity prostaglandin secretion response to lipopolysaccharide tetrahydrobiopterin binding arginine binding cellular response to drug regulation of cell proliferation negative regulation of protein catabolic process defense response to bacterium protein homodimerization activity cadherin binding negative regulation of blood pressure regulation of protein kinase activity metal ion binding perinuclear region of cytoplasm flavin adenine dinucleotide binding NADP binding regulation of insulin secretion nitric-oxide synthase binding positive regulation of killing of cells of other organism Hsp90 protein binding oxidation-reduction process cellular response to lipopolysaccharide cellular response to cytokine stimulus cellular response to interferon-gamma cellular response to organic cyclic compound interleukin-6 secretion interleukin-8 secretion regulation of cytokine production involved in inflammatory response ovulation from ovarian follicle uc007kkc.1 uc007kkc.2 uc007kkc.3 uc007kkc.4 
ENSMUST00000018614.3 Kcnab3 ENSMUST00000018614.3 potassium voltage-gated channel, shaker-related subfamily, beta member 3 (from RefSeq NM_010599.4) ENSMUST00000018614.1 ENSMUST00000018614.2 Kcnab3 NM_010599 Q8VD73 Q8VD73_MOUSE uc007jps.1 uc007jps.2 uc007jps.3 Cytoplasm Belongs to the shaker potassium channel beta subunit family. voltage-gated potassium channel activity cytoplasm potassium ion transport integral component of membrane potassium ion transmembrane transport uc007jps.1 uc007jps.2 uc007jps.3 
ENSMUST00000018623.4 Chct1 ENSMUST00000018623.4 CHD1 helical C-terminal domain containing 1 (from RefSeq NM_028589.1) CHCT1_MOUSE ENSMUST00000018623.1 ENSMUST00000018623.2 ENSMUST00000018623.3 NM_028589 Q5SX10 Q80ZN8 Q9D979 uc007kri.1 uc007kri.2 uc007kri.3 uc007kri.4 May play a role in regulation of apoptosis. Cytoplasm Note=Located in the cytoplasm of spermatogonia and spermatocytes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D979-1; Sequence=Displayed; Name=2; IsoId=Q9D979-2; Sequence=VSP_039026; Exclusively expressed in testes. The CHD1 helical C-terminal domain (CHCT) may bind DNA and nucleosomes. Sequence=AAH48674.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component biological_process uc007kri.1 uc007kri.2 uc007kri.3 uc007kri.4 
ENSMUST00000018625.10 Appbp2 ENSMUST00000018625.10 amyloid beta precursor protein binding protein 2 (from RefSeq NM_025825.3) APBP2_MOUSE Appbp2 ENSMUST00000018625.1 ENSMUST00000018625.2 ENSMUST00000018625.3 ENSMUST00000018625.4 ENSMUST00000018625.5 ENSMUST00000018625.6 ENSMUST00000018625.7 ENSMUST00000018625.8 ENSMUST00000018625.9 Kiaa0228 NM_025825 Q5SX12 Q80U61 Q9DAX9 uc007krj.1 uc007krj.2 uc007krj.3 uc007krj.4 Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa- Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface. E3 ubiquitin-protein ligase activity of the CRL2(APPBP2) complex is inhibited by APP. Protein modification; protein ubiquitination. Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter APPBP2. Interacts with APP; APP interaction inhibits the E3 ubiquitin- protein ligase activity of the CRL2(APPBP2) complex. Nucleus Cytoplasm, cytoskeleton Membrane ; Peripheral membrane protein Note=Associated with membranes and microtubules. Rapidly degraded by the proteasome upon overexpression of a C- terminal fragment of APP. protein binding nucleus cytoplasm cytoskeleton microtubule intracellular protein transport protein transport membrane cytoplasmic vesicle membrane intracellular transport uc007krj.1 uc007krj.2 uc007krj.3 uc007krj.4 
ENSMUST00000018630.3 Wnt9b ENSMUST00000018630.3 wingless-type MMTV integration site family, member 9B (from RefSeq NM_011719.4) ENSMUST00000018630.1 ENSMUST00000018630.2 NM_011719 Q2TBA6 Q2TBA6_MOUSE Wnt9b uc007lvr.1 uc007lvr.2 uc007lvr.3 Ligand for members of the frizzled family of seven transmembrane receptors. Secreted, extracellular space, extracellular matrix Belongs to the Wnt family. receptor binding extracellular region multicellular organism development Wnt signaling pathway receptor agonist activity canonical Wnt signaling pathway negative regulation of stem cell population maintenance midbrain dopaminergic neuron differentiation non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation uc007lvr.1 uc007lvr.2 uc007lvr.3 
ENSMUST00000018632.11 Myh4 ENSMUST00000018632.11 myosin, heavy polypeptide 4, skeletal muscle (from RefSeq NM_010855.3) B9EJ73 ENSMUST00000018632.1 ENSMUST00000018632.10 ENSMUST00000018632.2 ENSMUST00000018632.3 ENSMUST00000018632.4 ENSMUST00000018632.5 ENSMUST00000018632.6 ENSMUST00000018632.7 ENSMUST00000018632.8 ENSMUST00000018632.9 MYH4_MOUSE NM_010855 Q5SX39 uc287zbc.1 uc287zbc.2 Muscle contraction. Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents a conventional myosin. This protein should not be confused with the unconventional myosin-4 (MYO4). nucleotide binding double-stranded RNA binding motor activity actin binding calmodulin binding ATP binding cytoplasm muscle contraction response to activity myosin complex myofibril myosin filament actin filament binding uc287zbc.1 uc287zbc.2 
ENSMUST00000018644.3 Adora2b ENSMUST00000018644.3 adenosine A2b receptor (from RefSeq NM_007413.4) AA2BR_MOUSE ENSMUST00000018644.1 ENSMUST00000018644.2 NM_007413 Q60614 Q8BXI2 uc007jio.1 uc007jio.2 uc007jio.3 Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled adenosine receptor activity positive regulation of endothelial cell proliferation adenosine receptor signaling pathway positive regulation of chronic inflammatory response to non-antigenic stimulus G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation cell surface positive regulation of vascular endothelial growth factor production positive regulation of endothelial cell migration positive regulation of norepinephrine secretion positive regulation of cGMP-mediated signaling positive regulation of steroid biosynthetic process membrane integral component of membrane positive regulation of guanylate cyclase activity cellular response to extracellular stimulus positive regulation of chemokine production positive regulation of interleukin-6 production negative regulation of collagen biosynthetic process positive regulation of catecholamine secretion positive regulation of mast cell degranulation positive regulation of cAMP-mediated signaling synapse relaxation of vascular smooth muscle glutamatergic synapse regulation of synaptic vesicle exocytosis uc007jio.1 uc007jio.2 uc007jio.3 
ENSMUST00000018645.13 Ncor1 ENSMUST00000018645.13 Belongs to the N-CoR nuclear receptor corepressors family. (from UniProt Q5RIM6) ENSMUST00000018645.1 ENSMUST00000018645.10 ENSMUST00000018645.11 ENSMUST00000018645.12 ENSMUST00000018645.2 ENSMUST00000018645.3 ENSMUST00000018645.4 ENSMUST00000018645.5 ENSMUST00000018645.6 ENSMUST00000018645.7 ENSMUST00000018645.8 ENSMUST00000018645.9 Ncor1 Q5RIM6 Q5RIM6_MOUSE U35312 uc029rmb.1 uc029rmb.2 uc029rmb.3 Belongs to the N-CoR nuclear receptor corepressors family. histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II activating transcription factor binding DNA binding transcription corepressor activity nucleus nucleoplasm cytosol Sin3 complex transcriptional repressor complex nuclear hormone receptor binding histone deacetylase binding negative regulation of transcription, DNA-templated negative regulation of JNK cascade spindle assembly negative regulation of androgen receptor signaling pathway regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter mitotic spindle negative regulation of production of miRNAs involved in gene silencing by miRNA uc029rmb.1 uc029rmb.2 uc029rmb.3 
ENSMUST00000018651.14 Trpv2 ENSMUST00000018651.14 transient receptor potential cation channel, subfamily V, member 2, transcript variant 1 (from RefSeq NM_011706.2) ENSMUST00000018651.1 ENSMUST00000018651.10 ENSMUST00000018651.11 ENSMUST00000018651.12 ENSMUST00000018651.13 ENSMUST00000018651.2 ENSMUST00000018651.3 ENSMUST00000018651.4 ENSMUST00000018651.5 ENSMUST00000018651.6 ENSMUST00000018651.7 ENSMUST00000018651.8 ENSMUST00000018651.9 Grc NM_011706 Q99K71 Q9WTR1 TRPV2_MOUSE uc007jjh.1 uc007jjh.2 uc007jjh.3 Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF- I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (By similarity). Cell membrane; Multi-pass membrane protein. Cytoplasm. Melanosome Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation. Abundantly expressed in spleen, placenta, skeleton muscle, lung and brain. N-glycosylated. Phosphorylated by PKA. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily. ion channel activity cation channel activity calcium channel activity cytoplasm plasma membrane integral component of plasma membrane ion transport calcium ion transport negative regulation of cell proliferation response to temperature stimulus response to heat cell surface endomembrane system membrane integral component of membrane lamellipodium axon growth cone membrane melanosome identical protein binding axonal growth cone cell body positive regulation of axon extension transmembrane transport calcium ion transmembrane transport positive regulation of calcium ion import apoptotic process uc007jjh.1 uc007jjh.2 uc007jjh.3 
ENSMUST00000018653.8 Cenpv ENSMUST00000018653.8 centromere protein V (from RefSeq NM_028448.1) B2RWK8 B9EK22 CENPV_MOUSE ENSMUST00000018653.1 ENSMUST00000018653.2 ENSMUST00000018653.3 ENSMUST00000018653.4 ENSMUST00000018653.5 ENSMUST00000018653.6 ENSMUST00000018653.7 NM_028448 Prr6 Q5SX21 Q6PIA5 Q9CXS4 uc007jjf.1 uc007jjf.2 uc007jjf.3 uc007jjf.4 Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. Chromosome, centromere, kinetochore Nucleus Cytoplasm, cytoskeleton, spindle Note=Enriched at the nuclear periphery and around the nucleolus. In mitotic cells, localizes to kinetochores from prometaphase to metaphase. At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CXS4-1; Sequence=Displayed; Name=2; IsoId=Q9CXS4-2; Sequence=VSP_019551; Belongs to the Gfa family. chromosome, centromeric region kinetochore condensed chromosome kinetochore ameboidal-type cell migration molecular_function nucleus chromosome cytoplasm spindle cytoskeleton cell cycle microtubule cytoskeleton carbon-sulfur lyase activity pericentric heterochromatin assembly positive regulation of cytokinesis regulation of chromosome organization centromere complex assembly metal ion binding spindle midzone cell division uc007jjf.1 uc007jjf.2 uc007jjf.3 uc007jjf.4 
ENSMUST00000018685.9 Cwc25 ENSMUST00000018685.9 CWC25 spliceosome-associated protein (from RefSeq NM_026186.4) A2A6F4 CWC25_MOUSE Ccdc49 ENSMUST00000018685.1 ENSMUST00000018685.2 ENSMUST00000018685.3 ENSMUST00000018685.4 ENSMUST00000018685.5 ENSMUST00000018685.6 ENSMUST00000018685.7 ENSMUST00000018685.8 NM_026186 Q6AXH2 Q7TSF8 Q9DBF7 uc007ler.1 uc007ler.2 uc007ler.3 uc007ler.4 Involved in pre-mRNA splicing as component of the spliceosome. Identified in the spliceosome C complex. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DBF7-1; Sequence=Displayed; Name=2; IsoId=Q9DBF7-2; Sequence=VSP_025798; Name=3; IsoId=Q9DBF7-3; Sequence=VSP_025799; Belongs to the CWC25 family. mRNA splicing, via spliceosome molecular_function nucleus spliceosomal complex mRNA processing RNA splicing nuclear speck U2-type catalytic step 1 spliceosome uc007ler.1 uc007ler.2 uc007ler.3 uc007ler.4 
ENSMUST00000018691.9 Pip4k2b ENSMUST00000018691.9 phosphatidylinositol-5-phosphate 4-kinase, type II, beta (from RefSeq NM_054051.1) ENSMUST00000018691.1 ENSMUST00000018691.2 ENSMUST00000018691.3 ENSMUST00000018691.4 ENSMUST00000018691.5 ENSMUST00000018691.6 ENSMUST00000018691.7 ENSMUST00000018691.8 NM_054051 PI42B_MOUSE Pip4k2b Pip5k2b Q80XI4 Q8VHB2 uc007leq.1 uc007leq.2 Participates in the biosynthesis of phosphatidylinositol 4,5- bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. In collaboration with PIP4K2A, has a role in mediating autophagy in times of nutrient stress (PubMed:29727621). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:29727621). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:12280, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57795, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.149; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12281; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5- phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:55992, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:83423, ChEBI:CHEBI:84968, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55993; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5- phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + GDP + H(+); Xref=Rhea:RHEA:55964, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:58189, ChEBI:CHEBI:83423, ChEBI:CHEBI:84968; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55965; Evidence=; Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A; the interaction suppresses ubiquitination by the SPOP/CUL3 complex (By similarity). Probably interacts with PIP5K1A; the interaction inhibits PIP5K1A kinase activity (By similarity). Endoplasmic reticulum membrane ; Peripheral membrane protein Cell membrane ; Peripheral membrane protein Nucleus Cytoplasm Note=Associated with the plasma membrane and the endoplasmic reticulum. Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels. Phosphorylated on serine residues. nucleotide binding protein binding ATP binding nucleus nucleoplasm cytoplasm autophagosome endoplasmic reticulum endoplasmic reticulum membrane plasma membrane regulation of autophagy membrane kinase activity phosphatidylinositol phosphate kinase activity 1-phosphatidylinositol-4-phosphate 5-kinase activity 1-phosphatidylinositol-5-phosphate 4-kinase activity phosphorylation transferase activity protein homodimerization activity phosphatidylinositol metabolic process phosphatidylinositol phosphorylation positive regulation of autophagosome assembly uc007leq.1 uc007leq.2 
ENSMUST00000018710.13 Slc2a4 ENSMUST00000018710.13 solute carrier family 2 (facilitated glucose transporter), member 4, transcript variant 1 (from RefSeq NM_009204.2) ENSMUST00000018710.1 ENSMUST00000018710.10 ENSMUST00000018710.11 ENSMUST00000018710.12 ENSMUST00000018710.2 ENSMUST00000018710.3 ENSMUST00000018710.4 ENSMUST00000018710.5 ENSMUST00000018710.6 ENSMUST00000018710.7 ENSMUST00000018710.8 ENSMUST00000018710.9 GLUT4_MOUSE Glut4 NM_009204 P14142 Q3TPK6 Q9JJN9 Slc2a4 uc007jsz.1 uc007jsz.2 uc007jsz.3 Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation (PubMed:26240143, PubMed:26629404). Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells (PubMed:26240143, PubMed:26629404). Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell (PubMed:26240143, PubMed:26629404). Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, ChEBI:CHEBI:4167; Evidence=; Binds to DAXX (By similarity). Interacts via its N-terminus with SRFBP1 (By similarity). Interacts with NDUFA9 (By similarity). Interacts with TRARG1; the interaction is required for proper SLC2A4 recycling after insulin stimulation (PubMed:26629404). P14142; Q3U7R1: Esyt1; NbExp=2; IntAct=EBI-7540210, EBI-8398881; Cell membrane ulti-pass membrane protein Endomembrane system ; Multi-pass membrane protein Cytoplasm, perinuclear region te=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:26629404, PubMed:26240143, PubMed:27354378). The dileucine internalization motif is critical for intracellular sequestration (PubMed:26240143, PubMed:26629404). Insulin stimulation induces translocation to the cell membrane (PubMed:27739494). Expressed in skeletal and cardiac muscles (PubMed:2654938, PubMed:26240143). Expressed in brown and white adipose tissues (PubMed:2654938, PubMed:26240143). The dileucine internalization motif is critical for intracellular sequestration. Sumoylated. Palmitoylated. Palmitoylation by ZDHHC7 controls the insulin- dependent translocation of GLUT4 to the plasma membrane. Note=Defects in Slc2a4 may be the cause of certain post- receptor defects in non-insulin-dependent diabetes mellitus (NIDDM). Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. glucose transmembrane transporter activity insulin-responsive hydrogen:glucose symporter activity protein binding cytoplasm endosome multivesicular body cytosol plasma membrane integral component of plasma membrane clathrin-coated pit carbohydrate transport external side of plasma membrane cell surface amylopectin biosynthetic process endomembrane system vesicle membrane membrane integral component of membrane sarcoplasmic reticulum transmembrane transporter activity clathrin-coated vesicle trans-Golgi network transport vesicle T-tubule cytoplasmic vesicle membrane vesicle insulin-responsive compartment cellular response to insulin stimulus sarcolemma glucose homeostasis intracellular membrane-bounded organelle glucose import in response to insulin stimulus membrane raft response to ethanol glucose import perinuclear region of cytoplasm brown fat cell differentiation D-glucose transmembrane transporter activity transmembrane transport extracellular exosome cellular response to tumor necrosis factor cellular response to hypoxia cellular response to osmotic stress presynapse glucose transmembrane transport uc007jsz.1 uc007jsz.2 uc007jsz.3 
ENSMUST00000018711.15 Gabarap ENSMUST00000018711.15 gamma-aminobutyric acid receptor associated protein (from RefSeq NM_019749.4) B1AR49 ENSMUST00000018711.1 ENSMUST00000018711.10 ENSMUST00000018711.11 ENSMUST00000018711.12 ENSMUST00000018711.13 ENSMUST00000018711.14 ENSMUST00000018711.2 ENSMUST00000018711.3 ENSMUST00000018711.4 ENSMUST00000018711.5 ENSMUST00000018711.6 ENSMUST00000018711.7 ENSMUST00000018711.8 ENSMUST00000018711.9 GBRAP_MOUSE Gabarap NM_019749 Q9DCD6 Q9QUI7 uc007jtg.1 uc007jtg.2 uc007jtg.3 uc007jtg.4 Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction. Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation. Involved in apoptosis. Interacts with GPHN (PubMed:10900017). Interacts with NSF (By similarity). Interacts with ATG7 (PubMed:11890701). Interacts with ATG3 and ATG13 (By similarity). Interacts with alpha-tubulin (By similarity). Interacts with beta-tubulin (PubMed:10899939). Interacts with GABRG2 (By similarity). Interacts with RB1CC1 (By similarity). Interacts with ULK1 (By similarity). Interacts with CALR (By similarity). Interacts with DDX47 (By similarity). Interacts with TP53INP1 and TP53INP2 (By similarity). Interacts with TBC1D5 (By similarity). Interacts with TBC1D25 (PubMed:21383079). Directly interacts with SQSTM1 (By similarity). Interacts with MAPK15 (By similarity). Interacts with TECPR2 (By similarity). Interacts with PCM1 (By similarity). Interacts with TRIM5 and TRIM21 (By similarity). Interacts with MEFV (By similarity). Interacts with KIF21B (By similarity). Interacts with WDFY3; this interaction is required for WDFY3 recruitment to MAP1LC3B-positive p62/SQSTM1 bodies (By similarity). Interacts with FLCN; interaction regulates autophagy (By similarity). Interacts with UBA5 (By similarity). Interacts with KBTBD6 and KBTBD7; the interaction is direct and required for the ubiquitination of TIAM1 (By similarity). Interacts with reticulophagy regulators RETREG1, RETREG2 and RETREG3 (By similarity). Interacts with Irgm1 (By similarity). Interacts with STX17 (By similarity). Interacts with CT55; this interaction may be important for GABARAP protein stability (By similarity). Interacts with DNM2 (By similarity). Cytoplasmic vesicle, autophagosome membrane Endomembrane system Cytoplasm, cytoskeleton Golgi apparatus membrane Cytoplasmic vesicle Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (PubMed:10899939). Localizes also to discrete punctae along the ciliary axoneme (PubMed:24089209). The precursor molecule is cleaved by ATG4 (ATG4A, ATG4B, ATG4C or ATG4D) to expose the glycine at the C-terminus and form the cytosolic form, GABARAP-I (PubMed:14530254). The processed form is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, GABARAP-II (By similarity). During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid (By similarity). ATG4 proteins also mediate the delipidation of PE- conjugated forms (PubMed:33795848). In addition, ATG4B and ATG4D mediate delipidation of ATG8 proteins conjugated to PS during non- canonical autophagy (By similarity). ATG4B constitutes the major protein for proteolytic activation (By similarity). ATG4D is the main enzyme for delipidation activity (PubMed:33795848). Belongs to the ATG8 family. autophagosome assembly Golgi membrane microtubule cytoskeleton organization autophagosome membrane mitophagy protein binding cytoplasm lysosome autophagosome smooth endoplasmic reticulum Golgi apparatus cytosol cytoskeleton microtubule microtubule associated complex plasma membrane axoneme autophagy apoptotic process cellular response to nitrogen starvation microtubule binding extrinsic apoptotic signaling pathway via death domain receptors endomembrane system protein transport actin cytoskeleton membrane macroautophagy cytoplasmic vesicle ubiquitin protein ligase binding cell body perinuclear region of cytoplasm beta-tubulin binding GABA receptor binding sperm midpiece autophagosome maturation uc007jtg.1 uc007jtg.2 uc007jtg.3 uc007jtg.4 
ENSMUST00000018716.10 Phf23 ENSMUST00000018716.10 PHD finger protein 23, transcript variant 1 (from RefSeq NM_030064.4) ENSMUST00000018716.1 ENSMUST00000018716.2 ENSMUST00000018716.3 ENSMUST00000018716.4 ENSMUST00000018716.5 ENSMUST00000018716.6 ENSMUST00000018716.7 ENSMUST00000018716.8 ENSMUST00000018716.9 NM_030064 PHF23_MOUSE Phf23 Q3TCH1 Q8BSN5 Q8BT31 Q8CDY2 Q8CIA4 Q8CIU8 Q8CIU9 Q9CWC8 uc007jth.1 uc007jth.2 uc007jth.3 uc007jth.4 uc007jth.5 Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. Interacts with LRSAM1. Nucleus Cytoplasm Note=Mainly present in the nucleus and part in the cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BSN5-1; Sequence=Displayed; Name=2; Synonyms=JUNE1A; IsoId=Q8BSN5-2; Sequence=VSP_027965; Name=3; IsoId=Q8BSN5-3; Sequence=VSP_027964; The PHD-type zinc-finger domain is required for interaction with LRSAM1 and negative regulation of autophagy. Belongs to the PHF23 family. Sequence=AAH33533.1; Type=Erroneous initiation; Evidence=; Sequence=BAC25679.1; Type=Erroneous initiation; Evidence=; chromatin binding nucleus nucleoplasm cytoplasm autophagy mitotic chromosome condensation positive regulation of protein ubiquitination metal ion binding negative regulation of autophagosome maturation negative regulation of autophagosome assembly uc007jth.1 uc007jth.2 uc007jth.3 uc007jth.4 uc007jth.5 
ENSMUST00000018727.4 G3bp1 ENSMUST00000018727.4 G3BP stress granule assembly factor 1, transcript variant 1 (from RefSeq NM_013716.3) ENSMUST00000018727.1 ENSMUST00000018727.2 ENSMUST00000018727.3 G3BP1_MOUSE G3bp NM_013716 P97855 uc007izl.1 uc007izl.2 uc007izl.3 Protein involved in various processes, such as stress granule formation and innate immunity (By similarity). Plays an essential role in stress granule formation (By similarity). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (By similarity). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity). Also acts as an ATP- and magnesium- dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (By similarity). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (By similarity). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (By similarity). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (By similarity). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (By similarity). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles. Enhances also RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (By similarity). May also act as a phosphorylation-dependent sequence- specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Mg(2+) is required for helicase activity. ; Under physiological conditions, G3BP1 adopts a compact state that is stabilized by intramolecular interactions between the RG-rich and the acidic regions that inhibit phase separation. Upon stress, polysomes disassemble and mRNAs are released in an unfolded protein-free state. Binding of unfolded mRNA to G3BP1 outcompetes the intramolecular interactions and RNA-bound G3BP1 adopts an expanded conformation in which the RG-rich region becomes exposed to engage in protein-protein and protein-RNA interactions, allowing physical cross- linking of RNA molecules to form protein-RNA condensates, leading to liquid-liquid phase separation (LLPS). Homodimer and oligomer (By similarity). Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP1 (PubMed:15086518). Binds to the SH3 domain of Ras GTPase-activating protein (RASA1) in proliferating cells (PubMed:8649363). No interaction in quiescent cells (PubMed:8649363). Interacts (via NTF2 domain) with USP10; inhibiting stress granule formation by lowering G3BP1 valence (By similarity). Interacts (via NTF2 domain) with CAPRIN1; promoting stress granule formation by lowering the saturation-concentration of G3BP1 (By similarity). Interacts (via NTF2 domain) with UBAP2L; promoting stress granule formation (By similarity). Associates (via RG- rich region) with 40S ribosome subunits (By similarity). Interacts with RPTOR and SPAG5; this complex is increased by oxidative stress (By similarity). Interacts with ATXN2L (By similarity). Interacts with STYXL1 (By similarity). Interacts with CGAS (via N-terminus); this interaction promotes the DNA-binding and activation of CGAS (By similarity). Interacts (via C-terminus) with RIGI (By similarity). Interacts with PABPC1 (By similarity). Interacts with QKI (isoforms QKI6 and QKI7); directing N(7)-methylguanine-containing mRNAs to stress granules (By similarity). Cytoplasm, cytosol rikaryon Cytoplasm, Stress granule Nucleus Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells. Cytosolic and partially nuclear in resting cells. Recruited to stress granules in response to arsenite treatment. The unphosphorylated form is recruited to stress granules. HRAS signaling contributes to this process by regulating G3BP dephosphorylation. Ubiquitous. Can mediate both protein-protein and protein-RNA interactions via the NTF2 domain and RNA-binding domain RRM; protein-protein and protein-RNA interactions are essential for undergoing liquid-liquid phase separation (LLPS). The acidic disordered region acts as a negative regulator of phase separation. The NTF2 domain mediates interaction with CAPRIN1 and USP10 regulators, thereby regulating assembly of stress granules. Phosphorylation of the acidic disordered region regulates stress granule assembly. RASA1-dependent phosphorylation of Ser-149 induces a conformational change that prevents self-association. Dephosphorylation after HRAS activation is required for stress granule assembly. Ser-149 phosphorylation induces partial nuclear localization. Arg-435 is dimethylated, probably to asymmetric dimethylarginine. Ubiquitinated by TRIM21 via 'Lys-63'-linked polyubiquitination in the NTF2 domain in response to heat shock, leading to stress granule disassembly: ubiquitination promotes interaction with the FAF2 adapter, followed by interaction with VCP, which extracts G3BP1 from stress granules, leading to stress granule disassembly. In case of prolonged stress, ubiquitination by TRIM21 leads to autophagy-dependent degradation of G3BP1 via recruitment of ubiquitinated G3BP1 by SQSTM1 and/or CALCOCO2 to autophagosomes. nucleotide binding immune system process nucleic acid binding DNA binding DNA helicase activity RNA binding RNA helicase activity mRNA binding helicase activity nuclease activity endonuclease activity protein binding ATP binding nucleus cytoplasm cytosol cytoplasmic stress granule hydrolase activity DNA duplex unwinding type I interferon production stress granule assembly perikaryon innate immune response defense response to virus negative regulation of canonical Wnt signaling pathway nucleic acid phosphodiester bond hydrolysis ribonucleoprotein complex uc007izl.1 uc007izl.2 uc007izl.3 
ENSMUST00000018739.5 Glra4 ENSMUST00000018739.5 glycine receptor, alpha 4 subunit, transcript variant 1 (from RefSeq NM_010297.3) A2AEA9 ENSMUST00000018739.1 ENSMUST00000018739.2 ENSMUST00000018739.3 ENSMUST00000018739.4 GLRA4_MOUSE NM_010297 Q45V76 Q61603 Q8VHF3 uc009uiz.1 uc009uiz.2 uc009uiz.3 uc009uiz.4 Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine (PubMed:10762330). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (Probable). Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; Inhibited by strychnine (PubMed:10762330). Homopentamer (in vitro). Heteropentamer composed of GLRA4 and GLRB. Postsynaptic cell membrane ; Multi-pass membrane protein Synapse rikaryon Cell projection, dendrite Cell membrane ulti-pass membrane protein Detected in the retina inner plexiform layer, especially at the border between layer three and four (at protein level) (PubMed:17154252). The alpha subunit binds strychnine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA4 sub-subfamily. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction neuropeptide signaling pathway chemical synaptic transmission membrane integral component of membrane glycine binding extracellular-glycine-gated chloride channel activity transmitter-gated ion channel activity cell junction dendrite ion transmembrane transport chloride channel complex regulation of membrane potential cell projection neuron projection response to amino acid perikaryon synapse postsynaptic membrane neurological system process synaptic transmission, glycinergic excitatory postsynaptic potential integral component of postsynaptic specialization membrane chloride transmembrane transport uc009uiz.1 uc009uiz.2 uc009uiz.3 uc009uiz.4 
ENSMUST00000018743.5 Mief2 ENSMUST00000018743.5 mitochondrial elongation factor 2 (from RefSeq NM_001009927.2) ENSMUST00000018743.1 ENSMUST00000018743.2 ENSMUST00000018743.3 ENSMUST00000018743.4 Gm11 MID49_MOUSE Mid49 NM_001009927 Q5NCS9 Smcr7 uc007jgj.1 uc007jgj.2 Mitochondrial outer membrane protein which regulates mitochondrial organization. It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity. Interacts with DNM1L. Q5NCS9; Q8K1M6-3: Dnm1l; NbExp=2; IntAct=EBI-16092669, EBI-16092613; Mitochondrion outer membrane ; Single-pass membrane protein Note=Colocalizes with DNM1L at mitochondrial membrane. Forms foci and rings around mitochondria. Does not bind ADP or other nucleotides, in contrast to MIEF1. Belongs to the MID49/MID51 family. protein binding mitochondrion mitochondrial outer membrane mitochondrion organization regulation of mitochondrion organization membrane integral component of membrane positive regulation of protein homooligomerization positive regulation of mitochondrial fission positive regulation of protein targeting to membrane uc007jgj.1 uc007jgj.2 
ENSMUST00000018744.15 Shmt1 ENSMUST00000018744.15 serine hydroxymethyltransferase 1 (soluble), transcript variant 1 (from RefSeq NM_009171.3) ENSMUST00000018744.1 ENSMUST00000018744.10 ENSMUST00000018744.11 ENSMUST00000018744.12 ENSMUST00000018744.13 ENSMUST00000018744.14 ENSMUST00000018744.2 ENSMUST00000018744.3 ENSMUST00000018744.4 ENSMUST00000018744.5 ENSMUST00000018744.6 ENSMUST00000018744.7 ENSMUST00000018744.8 ENSMUST00000018744.9 GLYC_MOUSE NM_009171 P50431 Q64508 Q8R0X9 Shmt uc007jgo.1 uc007jgo.2 uc007jgo.3 Interconversion of serine and glycine. Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine; Xref=Rhea:RHEA:15481, ChEBI:CHEBI:15377, ChEBI:CHEBI:15636, ChEBI:CHEBI:33384, ChEBI:CHEBI:57305, ChEBI:CHEBI:57453; EC=2.1.2.1; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; One-carbon metabolism; tetrahydrofolate interconversion. Homotetramer (PubMed:11063567). Identified in complex with FAM175B and the other subunits of the BRISC complex, at least composed of FAM175B/ABRO1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Cytoplasm. In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one. Belongs to the SHMT family. translation repressor activity, nucleic acid binding catalytic activity glycine hydroxymethyltransferase activity nucleus cytoplasm mitochondrion cytosol dTMP biosynthetic process glycine metabolic process glycine biosynthetic process L-serine metabolic process L-serine catabolic process one-carbon metabolic process zinc ion binding L-allo-threonine aldolase activity purine nucleobase biosynthetic process amino acid binding transferase activity negative regulation of translation glycine biosynthetic process from serine pyridoxal phosphate binding tetrahydrofolate interconversion identical protein binding protein homodimerization activity tetrahydrofolate metabolic process folic acid metabolic process mRNA 5'-UTR binding cobalt ion binding protein tetramerization protein homotetramerization serine binding cellular response to tetrahydrofolate cellular response to leukemia inhibitory factor uc007jgo.1 uc007jgo.2 uc007jgo.3 
ENSMUST00000018755.10 Pdlim4 ENSMUST00000018755.10 PDZ and LIM domain 4, transcript variant 1 (from RefSeq NM_019417.4) ENSMUST00000018755.1 ENSMUST00000018755.2 ENSMUST00000018755.3 ENSMUST00000018755.4 ENSMUST00000018755.5 ENSMUST00000018755.6 ENSMUST00000018755.7 ENSMUST00000018755.8 ENSMUST00000018755.9 NM_019417 P70271 PDLI4_MOUSE Q5SWV2 Q8K0W4 Ril uc007ixf.1 uc007ixf.2 uc007ixf.3 uc007ixf.4 Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1- containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). Homodimer (By similarity). Interacts (via C-terminus only or via combined C-terminus and LIM domain, but not LIM domain only) with PTPN13 (via the second or fourth PDZ domains) (PubMed:9487134, PubMed:15663004). Found in a complex with PTPN13 and TRIP6 (PubMed:10826496). Interacts (via PDZ domain) with ACTN1 and ACTN2 (via C-terminal SDL residues) (By similarity). Interacts (via PDZ domain) with TRIP6 (via the second LIM domain or via the third LIM domain plus C-terminus) (PubMed:10826496). Interacts (via LIM domain) with GRIA1 (via C-terminus); this interaction as well as the interaction with alpha-actinin is required for their colocalization in early endosomes. Interacts with PDLIM1 (By similarity). Forms (via LIM domain) a heterodimer with PDLIM3 (PubMed:15663004). Interacts directly with SRC (via kinase domain and to a lesser extent the SH2 domain) (By similarity). P70271; Q9Z1Y4: Trip6; NbExp=2; IntAct=EBI-7288319, EBI-643879; Cytoplasm, cytoskeleton Cell projection, dendritic spine Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Recycling endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus Cytoplasm, perinuclear region Cell projection, lamellipodium Synapse, synaptosome Note=Localizes to actin stress fibers in nonmuscle cells. Colocalizes with GRIA1 in early endosomes. Enriched in numerous but not all spine-like structures along dendritic branches. Colocalizes with actin and enriched at sites containing larger amounts of actin and alpha-actinin. Targeted efficiently to spines via its PDZ domain-mediated interaction with the alpha-actinin/actin cytoskeletal complex. Localizes to synaptosomes in brain (By similarity). Colocalizes with F-actin. Colocalizes with TRIP6 at cell-cell contacts and lamellipodia. In the cytoplasm, displays a fibrillar pattern with characteristic thick fibers and occasional clusters. Colocalizes with the actin stress fibers. Oxidative stress induces redistribution from cytoskeleton to cytosol. Colocalizes with SRC at the perinuclear region, but not at focal adhesions (By similarity). Expressed in several non-muscle tissues including lung, brain, ovary and uterus, and especially in epithelial cells at 14 dpc. In the uterus, high expression in the glandular epithelium, but absent in the simple columnar epithelium lining the uterus cavity. Phosphorylated on tyrosine residue(s). Can be dephosphorylated by PTPN13. stress fiber actin binding protein binding nucleus cytoplasm endosome cytoskeleton cell-cell adherens junction heart development actin cytoskeleton membrane protein phosphatase binding Z disc lamellipodium actin cytoskeleton organization cell junction actin cytoskeleton reorganization early endosome membrane early endosome lumen filamentous actin recycling endosome lumen protein homodimerization activity actinin binding cell projection neuron projection dendritic spine synapse postsynaptic membrane metal ion binding perinuclear region of cytoplasm muscle alpha-actinin binding alpha-actinin binding positive regulation of stress fiber assembly recycling endosome membrane muscle structure development excitatory chemical synaptic transmission uc007ixf.1 uc007ixf.2 uc007ixf.3 uc007ixf.4 
ENSMUST00000018765.4 Mmp8 ENSMUST00000018765.4 matrix metallopeptidase 8 (from RefSeq NM_008611.4) ENSMUST00000018765.1 ENSMUST00000018765.2 ENSMUST00000018765.3 MMP8_MOUSE NM_008611 O70138 O88733 Q6GTR5 uc009ocr.1 uc009ocr.2 uc009ocr.3 uc009ocr.4 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades types I, II and III collagens. Mice lacking the encoded protein exhibit abnormalities in the inflammatory responses to various agents. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK089336.1, AK155901.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN00849388 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Can degrade fibrillar type I, II, and III collagens. May play a role in the degradation of collagen fibers during uterine involution. Reaction=Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.; EC=3.4.24.34; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Cannot be activated without removal of the activation peptide. Activated by matrilysin. Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules and released during inflammatory conditions. Neutrophils. Expressed in uterus. Low levels in kidney and muscle. Expressed in late embryogenesis and in the involuting postpartum uterus. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. Belongs to the peptidase M10A family. endopeptidase activity metalloendopeptidase activity serine-type endopeptidase activity calcium ion binding extracellular region extracellular space proteolysis peptidase activity metallopeptidase activity zinc ion binding positive regulation of gene expression negative regulation of gene expression hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix negative regulation of interleukin-10 production positive regulation of interleukin-6 production endodermal cell differentiation positive regulation of DNA binding positive regulation of MAPK cascade positive regulation of nitric oxide biosynthetic process positive regulation of JNK cascade metal ion binding positive regulation of NIK/NF-kappaB signaling positive regulation of reactive oxygen species biosynthetic process positive regulation of microglial cell activation positive regulation of tumor necrosis factor secretion uc009ocr.1 uc009ocr.2 uc009ocr.3 uc009ocr.4 
ENSMUST00000018767.9 Mmp7 ENSMUST00000018767.9 matrix metallopeptidase 7, transcript variant 1 (from RefSeq NM_010810.6) ENSMUST00000018767.1 ENSMUST00000018767.2 ENSMUST00000018767.3 ENSMUST00000018767.4 ENSMUST00000018767.5 ENSMUST00000018767.6 ENSMUST00000018767.7 ENSMUST00000018767.8 Mmp7 NM_010810 Q3UN27 Q3UN27_MOUSE uc009ocv.1 uc009ocv.2 uc009ocv.3 uc009ocv.4 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein are deficient in functional cryptdins. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Can bind about 5 Ca(2+) ions per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. Belongs to the peptidase M10A family. metalloendopeptidase activity extracellular space proteolysis aging heparin binding peptidase activity metallopeptidase activity zinc ion binding cell surface hydrolase activity extracellular matrix response to nutrient levels estrous cycle metal ion binding maternal process involved in female pregnancy cellular response to mechanical stimulus uc009ocv.1 uc009ocv.2 uc009ocv.3 uc009ocv.4 
ENSMUST00000018792.12 Dusp14 ENSMUST00000018792.12 dual specificity phosphatase 14, transcript variant 6 (from RefSeq NM_001408745.1) DUS14_MOUSE ENSMUST00000018792.1 ENSMUST00000018792.10 ENSMUST00000018792.11 ENSMUST00000018792.2 ENSMUST00000018792.3 ENSMUST00000018792.4 ENSMUST00000018792.5 ENSMUST00000018792.6 ENSMUST00000018792.7 ENSMUST00000018792.8 ENSMUST00000018792.9 Mkp6 NM_001408745 Q9D715 Q9JLY7 uc007kqe.1 uc007kqe.2 uc007kqe.3 Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. Plays a negative role in TCR signaling by dephosphorylating MAP3K7 adapter TAB1 leading to its inactivation. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. inactivation of MAPK activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity peptidyl-tyrosine dephosphorylation uc007kqe.1 uc007kqe.2 uc007kqe.3 
ENSMUST00000018795.13 Tada2a ENSMUST00000018795.13 transcriptional adaptor 2A (from RefSeq NM_172562.3) ENSMUST00000018795.1 ENSMUST00000018795.10 ENSMUST00000018795.11 ENSMUST00000018795.12 ENSMUST00000018795.2 ENSMUST00000018795.3 ENSMUST00000018795.4 ENSMUST00000018795.5 ENSMUST00000018795.6 ENSMUST00000018795.7 ENSMUST00000018795.8 ENSMUST00000018795.9 NM_172562 Q3TZD7 Q8BNK0 Q8CHV6 Q8R3H5 TAD2A_MOUSE Tada2l uc007kqf.1 uc007kqf.2 uc007kqf.3 Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA (PubMed:16299514). Binds dinucleosomes, probably at the linker region between neighboring nucleosomes (PubMed:16299514). Plays a role in chromatin remodeling (By similarity). May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (By similarity). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (By similarity). Interacts with GCN5. Interacts with NR3C1. Associated with the P/CAF protein in the PCAF complex. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. Interacts with CCDC134. Nucleus romosome Sequence=AAH25448.1; Type=Erroneous initiation; Evidence=; Sequence=BAC38925.1; Type=Erroneous initiation; Evidence=; PCAF complex mitotic cell cycle regulation of protein phosphorylation DNA binding chromatin binding transcription coactivator activity nucleus Ada2/Gcn5/Ada3 transcription activator complex chromosome chromatin remodeling regulation of transcription from RNA polymerase II promoter regulation of histone deacetylation regulation of protein stability regulation of histone acetylation positive regulation of histone acetylation histone H3 acetylation SAGA-type complex mitotic spindle regulation of tubulin deacetylation positive regulation of nucleic acid-templated transcription histone acetyltransferase activity uc007kqf.1 uc007kqf.2 uc007kqf.3 
ENSMUST00000018800.9 Myl4 ENSMUST00000018800.9 myosin, light polypeptide 4, transcript variant 3 (from RefSeq NM_010858.5) ENSMUST00000018800.1 ENSMUST00000018800.2 ENSMUST00000018800.3 ENSMUST00000018800.4 ENSMUST00000018800.5 ENSMUST00000018800.6 ENSMUST00000018800.7 ENSMUST00000018800.8 Myl4 NM_010858 Q9CZ19 Q9CZ19_MOUSE uc007lwt.1 uc007lwt.2 uc007lwt.3 regulation of the force of heart contraction actin monomer binding calcium ion binding A band positive regulation of ATPase activity actin filament binding cardiac muscle contraction uc007lwt.1 uc007lwt.2 uc007lwt.3 
ENSMUST00000018803.12 Pnpo ENSMUST00000018803.12 pyridoxine 5'-phosphate oxidase (from RefSeq NM_134021.2) ENSMUST00000018803.1 ENSMUST00000018803.10 ENSMUST00000018803.11 ENSMUST00000018803.2 ENSMUST00000018803.3 ENSMUST00000018803.4 ENSMUST00000018803.5 ENSMUST00000018803.6 ENSMUST00000018803.7 ENSMUST00000018803.8 ENSMUST00000018803.9 NM_134021 PNPO_MOUSE Q3TP70 Q3U445 Q3U4X1 Q91XF0 uc007ldc.1 uc007ldc.2 uc007ldc.3 Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). Reaction=H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate; Xref=Rhea:RHEA:15817, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:58451, ChEBI:CHEBI:597326; EC=1.4.3.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15818; Evidence=; Reaction=O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate; Xref=Rhea:RHEA:15149, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:58589, ChEBI:CHEBI:597326; EC=1.4.3.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15150; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Note=Binds 1 FMN per subunit. ; Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1. Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1. Homodimer. Belongs to the pyridoxamine 5'-phosphate oxidase family. Sequence=BAE32590.1; Type=Erroneous initiation; Evidence=; pyridoxamine-phosphate oxidase activity nucleoplasm cytosol pyridoxine biosynthetic process FMN binding oxidoreductase activity oxidoreductase activity, acting on the CH-NH2 group of donors pyridoxal phosphate binding protein homodimerization activity pyridoxal phosphate biosynthetic process cofactor binding oxidation-reduction process uc007ldc.1 uc007ldc.2 uc007ldc.3 
ENSMUST00000018805.15 Cog1 ENSMUST00000018805.15 component of oligomeric golgi complex 1 (from RefSeq NM_013581.3) COG1_MOUSE ENSMUST00000018805.1 ENSMUST00000018805.10 ENSMUST00000018805.11 ENSMUST00000018805.12 ENSMUST00000018805.13 ENSMUST00000018805.14 ENSMUST00000018805.2 ENSMUST00000018805.3 ENSMUST00000018805.4 ENSMUST00000018805.5 ENSMUST00000018805.6 ENSMUST00000018805.7 ENSMUST00000018805.8 ENSMUST00000018805.9 Ldlb NM_013581 Q6P567 Q9Z160 uc007mer.1 uc007mer.2 uc007mer.3 uc007mer.4 Required for normal Golgi function. Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the COG1 family. Golgi membrane Golgi apparatus intra-Golgi vesicle-mediated transport protein transport membrane Golgi transport complex uc007mer.1 uc007mer.2 uc007mer.3 uc007mer.4 
ENSMUST00000018816.14 Copz2 ENSMUST00000018816.14 coatomer protein complex, subunit zeta 2 (from RefSeq NM_019877.2) A2A6D6 COPZ2_MOUSE ENSMUST00000018816.1 ENSMUST00000018816.10 ENSMUST00000018816.11 ENSMUST00000018816.12 ENSMUST00000018816.13 ENSMUST00000018816.2 ENSMUST00000018816.3 ENSMUST00000018816.4 ENSMUST00000018816.5 ENSMUST00000018816.6 ENSMUST00000018816.7 ENSMUST00000018816.8 ENSMUST00000018816.9 NM_019877 Q9JHH9 uc007lcu.1 uc007lcu.2 uc007lcu.3 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. Oligomeric complex. Cytoplasm, cytosol Endoplasmic reticulum-Golgi intermediate compartment membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows a significant preference for ERGIC and cis-Golgi apparatus compared with trans-Golgi network. Belongs to the adaptor complexes small subunit family. Golgi membrane molecular_function cytoplasm Golgi apparatus cytosol intracellular protein transport retrograde vesicle-mediated transport, Golgi to ER intra-Golgi vesicle-mediated transport protein transport membrane vesicle-mediated transport COPI vesicle coat COPI-coated vesicle COPI-coated vesicle membrane cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment membrane uc007lcu.1 uc007lcu.2 uc007lcu.3 
ENSMUST00000018821.9 Slc25a39 ENSMUST00000018821.9 solute carrier family 25, member 39 (from RefSeq NM_026542.3) D11Ertd333e ENSMUST00000018821.1 ENSMUST00000018821.2 ENSMUST00000018821.3 ENSMUST00000018821.4 ENSMUST00000018821.5 ENSMUST00000018821.6 ENSMUST00000018821.7 ENSMUST00000018821.8 NM_026542 Q3TTM8 Q9D8K8 S2539_MOUSE Slc25a39 uc007lrt.1 uc007lrt.2 uc007lrt.3 uc007lrt.4 uc007lrt.5 uc007lrt.6 Mitochondrial transporter required for glutathione import into mitochondria (PubMed:34707288). Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron- sulfur clusters, as well as erythropoiesis (PubMed:34707288). Reaction=glutathione(in) = glutathione(out); Xref=Rhea:RHEA:74819, ChEBI:CHEBI:57925; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Abundant expression in bone marrow, spleen, testis and kidney. Highly express in primitive erythroblast that fill yorlk sac blood islands at early somite pair stages, and in fetal liver at 12.5 dpc. Embryonic lethality at dpc 13.5 (PubMed:34707288). Embryos are pale due to a severely anemic phenotype (PubMed:34707288). Conditional deletion in the erythroid lineage also leads to severe anemia, characterized by a complete absence of Ter119(+) cells, iron overload and increased apoptosis in fetal liver cells (PubMed:34707288). Cells lacking both Slc25a39 and Slc25a40 show defects in the activity and stability of proteins containing iron- sulfur clusters (PubMed:34707288). Belongs to the mitochondrial carrier (TC 2.A.29) family. mitochondrion mitochondrial inner membrane heme biosynthetic process membrane integral component of membrane uc007lrt.1 uc007lrt.2 uc007lrt.3 uc007lrt.4 uc007lrt.5 uc007lrt.6 
ENSMUST00000018841.3 Aatf ENSMUST00000018841.3 apoptosis antagonizing transcription factor (from RefSeq NM_019816.1) AATF_MOUSE Che1 ENSMUST00000018841.1 ENSMUST00000018841.2 NM_019816 Q7TQN1 Q8C5Q2 Q99P89 Q9JKX4 Trb uc007kqm.1 uc007kqm.2 uc007kqm.3 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with POLR2J, RB1/RB, RBL1/P107 and RBL2/P130. Interacts with PAWR and SP1. May also bind MAPT. Nucleus, nucleolus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9JKX4-1; Sequence=Displayed; Name=2; IsoId=Q9JKX4-2; Sequence=VSP_014897, VSP_014898; Name=3; IsoId=Q9JKX4-3; Sequence=VSP_014899, VSP_014900; Expressed in adrenal gland, brain (Purkinje cells), heart, kidney, liver, lung, muscle, ovary and testis (at the protein level). Expressed uniformly throughout the embryo until 10.5 dpc. From 11.5 dpc, the relative expression level increases in the liver, hind brain, spinal cord, dorsal root ganglia, and the posterior commissure. Belongs to the AATF family. protein binding nucleus nucleolus cytoplasm Golgi apparatus cytosol cellular response to DNA damage stimulus regulation of mitotic cell cycle protein kinase binding negative regulation of superoxide anion generation ribosome biogenesis negative regulation of amyloid precursor protein biosynthetic process negative regulation of apoptotic process leucine zipper domain binding nuclear transcription factor complex positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter tau protein binding negative regulation of reactive oxygen species metabolic process negative regulation of apoptotic signaling pathway uc007kqm.1 uc007kqm.2 uc007kqm.3 
ENSMUST00000018842.14 Lhx1 ENSMUST00000018842.14 LIM homeobox protein 1 (from RefSeq NM_008498.3) ENSMUST00000018842.1 ENSMUST00000018842.10 ENSMUST00000018842.11 ENSMUST00000018842.12 ENSMUST00000018842.13 ENSMUST00000018842.2 ENSMUST00000018842.3 ENSMUST00000018842.4 ENSMUST00000018842.5 ENSMUST00000018842.6 ENSMUST00000018842.7 ENSMUST00000018842.8 ENSMUST00000018842.9 Lhx1 NM_008498 Q569N5 Q569N5_MOUSE uc007kqo.1 uc007kqo.2 uc007kqo.3 Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. Interacts with LDB1 via the tandem LIM domains. Nucleus DNA binding nucleus regulation of transcription, DNA-templated metanephric part of ureteric bud development sequence-specific DNA binding cellular response to fibroblast growth factor stimulus metal ion binding mesonephric tubule development mesonephric duct development metanephric glomerulus development metanephric comma-shaped body morphogenesis metanephric S-shaped body morphogenesis uc007kqo.1 uc007kqo.2 uc007kqo.3 
ENSMUST00000018851.14 Dync1h1 ENSMUST00000018851.14 dynein cytoplasmic 1 heavy chain 1 (from RefSeq NM_030238.2) DYHC1_MOUSE Dhc1 Dnch1 Dnchc1 Dyhc E9QM71 ENSMUST00000018851.1 ENSMUST00000018851.10 ENSMUST00000018851.11 ENSMUST00000018851.12 ENSMUST00000018851.13 ENSMUST00000018851.2 ENSMUST00000018851.3 ENSMUST00000018851.4 ENSMUST00000018851.5 ENSMUST00000018851.6 ENSMUST00000018851.7 ENSMUST00000018851.8 ENSMUST00000018851.9 NM_030238 Q9JHU4 uc007pbo.1 uc007pbo.2 uc007pbo.3 Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression. Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non- catalytic subunits. The ICs and LICs bind directly to the HC dimer and dynein LCs assemble on the IC dimer. Interacts with DYNC1LI1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1LI2; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1I2 (By similarity). Interacts with BICD2 (PubMed:22956769). Interacts with DNALI1 (PubMed:16496424). Q9JHU4; P07141: Csf1; NbExp=2; IntAct=EBI-645061, EBI-777188; Cytoplasm, cytoskeleton. Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function. Note=Defects in Dync1h1 are the cause of the 'Legs at odd angles' (LOA) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. LOA mutants display defects in migration of facial motor neuron cell bodies and impaired retrograde transport in spinal cord motor neurons. Note=Defects in Dync1h1 are the cause of the Cramping 1 (Cra1) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. Belongs to the dynein heavy chain family. nucleotide binding mitotic cell cycle manchette cilium movement motor activity microtubule motor activity protein binding ATP binding nuclear envelope cytoplasm centrosome cytoskeleton cytoplasmic dynein complex microtubule cytoplasmic microtubule cell cortex microtubule-based movement cell cycle nuclear migration retrograde axonal transport ATP-dependent microtubule motor activity, minus-end-directed filopodium dynein complex axon cytoplasmic microtubule organization positive regulation of intracellular transport cytoplasmic mRNA processing body assembly stress granule assembly neuronal cell body dynein intermediate chain binding establishment of spindle localization cell division dynein light intermediate chain binding regulation of mitotic spindle organization minus-end-directed vesicle transport along microtubule regulation of metaphase plate congression axon cytoplasm uc007pbo.1 uc007pbo.2 uc007pbo.3 
ENSMUST00000018875.13 Ap2b1 ENSMUST00000018875.13 adaptor-related protein complex 2, beta 1 subunit, transcript variant 1 (from RefSeq NM_001035854.2) AP2B1_MOUSE Clapb1 ENSMUST00000018875.1 ENSMUST00000018875.10 ENSMUST00000018875.11 ENSMUST00000018875.12 ENSMUST00000018875.2 ENSMUST00000018875.3 ENSMUST00000018875.4 ENSMUST00000018875.5 ENSMUST00000018875.6 ENSMUST00000018875.7 ENSMUST00000018875.8 ENSMUST00000018875.9 NM_001035854 Q80XJ4 Q9DBG3 uc007kot.1 uc007kot.2 uc007kot.3 uc007kot.4 Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L- [LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non- clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly (By similarity). Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1) (By similarity). Interacts with EPN1 (By similarity). Interacts with EPS15; clathrin competes with EPS15 (By similarity). Interacts with SNAP91; clathrin competes with SNAP91 (By similarity). Interacts with CLTC; clathrin competes with EPS15, SNAP91 and PIP5K1C (By similarity). Interacts with LDLRAP1 (By similarity). Interacts with AMPH and BIN1 (By similarity). Interacts with ARF6 (GDP- bound) (By similarity). Interacts (dephosphorylated at Tyr-737) with ARRB1; phosphorylation of AP2B1 at Tyr-737 disrupts the interaction (By similarity). Interacts with SLC2A8 (By similarity). Interacts with SCYL1 and SCYL2. Interacts with TGFBR1 and TGFBR2 (By similarity). Interacts with PIP5K1C; clathrin competes with PIP5K1C (By similarity). Interacts with DENND1B (By similarity). Interacts with FCHO1 (By similarity). Interacts with RFTN1 (By similarity). Interacts with KIAA1107 (PubMed:29262337). Together with AP2A1 or AP2A2 and AP2M1, it interacts with ADAM10; this interaction facilitates ADAM10 endocytosis from the plasma membrane during long-term potentiation in hippocampal neurons (PubMed:23676497). Q9DBG3; Q64729: Tgfbr1; NbExp=2; IntAct=EBI-775229, EBI-2899393; Q9DBG3; P48023: FASLG; Xeno; NbExp=2; IntAct=EBI-775229, EBI-495538; Q9DBG3-1; O70161: Pip5k1c; NbExp=3; IntAct=EBI-775239, EBI-773657; Q9DBG3-2; O70161: Pip5k1c; NbExp=8; IntAct=EBI-7257021, EBI-773657; Cell membrane Membrane, coated pit ; Peripheral membrane protein ; Cytoplasmic side Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DBG3-1; Sequence=Displayed; Name=2; IsoId=Q9DBG3-2; Sequence=VSP_011491; Expressed in the brain (at protein level). Belongs to the adaptor complexes large subunit family. cardiac septum development ventricular septum development protein binding plasma membrane clathrin-coated pit intracellular protein transport endocytosis heart development protein transport membrane vesicle-mediated transport membrane coat clathrin coat AP-2 adaptor complex clathrin adaptor complex clathrin binding aorta development macromolecular complex binding positive regulation of endocytosis clathrin coat assembly coronary vasculature development clathrin-dependent endocytosis postsynapse postsynaptic neurotransmitter receptor internalization glutamatergic synapse neurotransmitter receptor internalization negative regulation of neuron death positive regulation of protein localization to membrane uc007kot.1 uc007kot.2 uc007kot.3 uc007kot.4 
ENSMUST00000018877.9 Pex12 ENSMUST00000018877.9 peroxisomal biogenesis factor 12, transcript variant 1 (from RefSeq NM_134025.4) ENSMUST00000018877.1 ENSMUST00000018877.2 ENSMUST00000018877.3 ENSMUST00000018877.4 ENSMUST00000018877.5 ENSMUST00000018877.6 ENSMUST00000018877.7 ENSMUST00000018877.8 NM_134025 PEX12_MOUSE Q8VC48 uc007koq.1 uc007koq.2 uc007koq.3 Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity). Protein modification; protein ubiquitination. Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12. Interacts with PEX19 via its cytoplasmic domain. Peroxisome membrane ; Multi-pass membrane protein The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex. The RING-type zinc-finger is degenerated and only coordinates one zinc ions, preventing E3 ubiquitin-protein ligase activity. Belongs to the pex2/pex10/pex12 family. ubiquitin-protein transferase activity peroxisome peroxisomal membrane integral component of peroxisomal membrane protein monoubiquitination protein targeting to peroxisome peroxisome organization protein C-terminus binding zinc ion binding protein transport membrane integral component of membrane protein import into peroxisome matrix metal ion binding peroxisomal importomer complex uc007koq.1 uc007koq.2 uc007koq.3 
ENSMUST00000018880.14 Ndel1 ENSMUST00000018880.14 nudE neurodevelopment protein 1 like 1, transcript variant 1 (from RefSeq NM_023668.3) ENSMUST00000018880.1 ENSMUST00000018880.10 ENSMUST00000018880.11 ENSMUST00000018880.12 ENSMUST00000018880.13 ENSMUST00000018880.2 ENSMUST00000018880.3 ENSMUST00000018880.4 ENSMUST00000018880.5 ENSMUST00000018880.6 ENSMUST00000018880.7 ENSMUST00000018880.8 ENSMUST00000018880.9 NDEL1_MOUSE NM_023668 Nudel Q9D0Q4 Q9EPT6 Q9ERR1 uc007joc.1 uc007joc.2 uc007joc.3 uc007joc.4 uc007joc.5 uc007joc.6 Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970). Interacts with PLEKHM1 (via N- and C-terminus) (PubMed:27777970). Interacts with dynactin, PCM1 and PCNT. Interacts (via C-terminus) with CENPF (By similarity). Self-associates. Interacts with DISC1, dynein, tubulin gamma, KATNA1, KATNB1, microtubules, PAFAHB1 and YWHAE. Interacts directly with NEFL and indirectly with NEFH. Interacts with ZNF365 (By similarity). Q9ERR1; Q9ERR1: Ndel1; NbExp=3; IntAct=EBI-646668, EBI-646668; Q9ERR1; P63005: Pafah1b1; NbExp=9; IntAct=EBI-646668, EBI-917499; Q9ERR1; P62259: Ywhae; NbExp=7; IntAct=EBI-646668, EBI-356480; Q9ERR1; Q9NRI5: DISC1; Xeno; NbExp=2; IntAct=EBI-646668, EBI-529989; Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle. Note=Localizes to the kinetochore in a CENPF-dependent manner. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Localizes to the interphase centrosome and the mitotic spindle. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ERR1-1; Sequence=Displayed; Name=2; IsoId=Q9ERR1-2; Sequence=VSP_019311; Expressed in brain, liver, lung and testis (at protein level). Expressed in brain, epididymis, eye, heart, kidney, large intestine, liver, ovary, pancreas, prostate, skeletal muscle, smooth muscle, spleen, submaxillary gland, testis, thymus and thyroid. Within the brain expression is pronounced in the cortex, hippocampus, olfactory bulb, striatum, thalamic and hypothalamic structures and in the molecular layer of the cerebellum. Largely excluded from cortical progenitor cells which express NDE1. Expression in the brain is detectable from 7 dpc, rises at 15 dpc and 17 dpc and peaks at P5. Enriched in the developing cortex, particularly in neuroblasts of the ventricular zone and postmitotic migrating cortical plate neurons. Interaction with DISC1 in the brain is developmentally regulated, peaking at 17 dpc and decreasing at P16 so as to be undetectable in the adult brain. Expressed in the testis from P12, when zygotene spermatocytes first appear, and expression subsequently rises at P27. Phosphorylated by CDK1 and MAPK1 (By similarity). Phosphorylated in mitosis. Phosphorylated by CDK5. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE. Palmitoylation at Cys-273 reduces affinity for dynein. Belongs to the nudE family. establishment of mitotic spindle orientation microtubule cytoskeleton organization chromosome, centromeric region kinetochore condensed chromosome kinetochore neuron migration inner cell mass cell proliferation protein binding nuclear envelope chromosome cytoplasm centrosome microtubule organizing center spindle cytosol cytoskeleton kinesin complex microtubule microtubule associated complex proteolysis microtubule nucleation chromosome segregation mitotic centrosome separation multicellular organism development nervous system development microtubule binding synaptic vesicle retrograde axonal transport insulin receptor signaling pathway regulation of neuron projection development cell migration cerebral cortex radially oriented cell migration central nervous system neuron axonogenesis cell differentiation axon neuron projection development cell leading edge lysosome localization regulation of intracellular protein transport identical protein binding alpha-tubulin binding axon hillock positive regulation of GTPase activity cell body macromolecular complex binding positive regulation of axon extension vesicle transport along microtubule beta-tubulin binding positive regulation of axon regeneration nuclear envelope disassembly establishment of chromosome localization centrosome localization neurofilament cytoskeleton organization neurofilament cytoskeleton oligopeptidase activity activation of GTPase activity central region of growth cone positive regulation of ruffle assembly axon cytoplasm neuron projection extension regulation of microtubule motor activity canonical Wnt signaling pathway uc007joc.1 uc007joc.2 uc007joc.3 uc007joc.4 uc007joc.5 uc007joc.6 
ENSMUST00000018896.14 Tnfsf13 ENSMUST00000018896.14 tumor necrosis factor (ligand) superfamily, member 13, transcript variant 1 (from RefSeq NM_023517.2) ENSMUST00000018896.1 ENSMUST00000018896.10 ENSMUST00000018896.11 ENSMUST00000018896.12 ENSMUST00000018896.13 ENSMUST00000018896.2 ENSMUST00000018896.3 ENSMUST00000018896.4 ENSMUST00000018896.5 ENSMUST00000018896.6 ENSMUST00000018896.7 ENSMUST00000018896.8 ENSMUST00000018896.9 NM_023517 Q5F2A4 Q5F2A4_MOUSE Tnfsf13 uc007jre.1 uc007jre.2 uc007jre.3 Secreted Belongs to the tumor necrosis factor family. cytokine activity tumor necrosis factor receptor binding extracellular space cytoplasm immune response signal transduction membrane integral component of membrane positive regulation of isotype switching to IgA isotypes uc007jre.1 uc007jre.2 uc007jre.3 
ENSMUST00000018905.12 Mpdu1 ENSMUST00000018905.12 mannose-P-dolichol utilization defect 1, transcript variant 4 (from RefSeq NR_125917.1) ENSMUST00000018905.1 ENSMUST00000018905.10 ENSMUST00000018905.11 ENSMUST00000018905.2 ENSMUST00000018905.3 ENSMUST00000018905.4 ENSMUST00000018905.5 ENSMUST00000018905.6 ENSMUST00000018905.7 ENSMUST00000018905.8 ENSMUST00000018905.9 Mpdu1 NR_125917 Q8R0J2 Q8R0J2_MOUSE uc007jqv.1 uc007jqv.2 uc007jqv.3 uc007jqv.4 uc007jqv.5 This gene encodes a member of the PQ-loop superfamily. A similar gene in human encodes a protein that is required for monosaccharide-P-dolichol-dependent glycosyltransferase reactions, and disruption of this gene is the cause of congenital disorder of glycosylation (CDG) type 1F, a disease linked to defects in protein N-glycosylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors. Membrane ulti-pass membrane protein Belongs to the MPDU1 (TC 2.A.43.3) family. oligosaccharide biosynthetic process membrane integral component of membrane uc007jqv.1 uc007jqv.2 uc007jqv.3 uc007jqv.4 uc007jqv.5 
ENSMUST00000018909.4 Fxr2 ENSMUST00000018909.4 FMR1 autosomal homolog 2 (from RefSeq NM_011814.2) ENSMUST00000018909.1 ENSMUST00000018909.2 ENSMUST00000018909.3 Fxr2 Fxr2h NM_011814 Q6P5B5 Q6P5B5_MOUSE uc007jqt.1 uc007jqt.2 uc007jqt.3 Cytoplasm, Cytoplasmic ribonucleoprotein granule Postsynapse Synapse Belongs to the FMR1 family. nucleic acid binding RNA binding mRNA binding cytoplasm cytosol regulation of translation identical protein binding protein homodimerization activity protein heterodimerization activity uc007jqt.1 uc007jqt.2 uc007jqt.3 
ENSMUST00000018914.3 Atp5mc3 ENSMUST00000018914.3 ATP synthase membrane subunit c locus 3, transcript variant 2 (from RefSeq NM_175015.3) Atp5g3 Atp5mc3 ENSMUST00000018914.1 ENSMUST00000018914.2 NM_175015 Q14BC2 Q14BC2_MOUSE uc008kdm.1 uc008kdm.2 uc008kdm.3 The protein encoded by this gene is a subunit of mitochondrial membrane ATP synthase, the enzyme that catalyzes ATP synthesis during oxidative phosphorylation. This gene encodes subunit 9, which is present in multiple copies in the transmembrane part of the ATP synthase complex. Phenotype and gene expression profiles suggest correlations between this gene and alcoholism- and obesity-related phenotypes. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Sep 2014]. Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. Membrane ; Multi- pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Belongs to the ATPase C chain family. ion transport lipid binding hydrogen ion transmembrane transporter activity ATP synthesis coupled proton transport membrane integral component of membrane proton-transporting two-sector ATPase complex, proton-transporting domain proton-transporting ATP synthase complex, coupling factor F(o) hydrogen ion transmembrane transport uc008kdm.1 uc008kdm.2 uc008kdm.3 
ENSMUST00000018965.4 Avpi1 ENSMUST00000018965.4 arginine vasopressin-induced 1 (from RefSeq NM_027106.4) AVPI1_MOUSE ENSMUST00000018965.1 ENSMUST00000018965.2 ENSMUST00000018965.3 NM_027106 Q9D7H4 uc008hnh.1 uc008hnh.2 uc008hnh.3 May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling. By vasopressin. activation of MAPK activity molecular_function cellular_component cell cycle uc008hnh.1 uc008hnh.2 uc008hnh.3 
ENSMUST00000018966.8 Sfrp5 ENSMUST00000018966.8 secreted frizzled-related sequence protein 5 (from RefSeq NM_018780.3) A0A0R4J001 A0A0R4J001_MOUSE ENSMUST00000018966.1 ENSMUST00000018966.2 ENSMUST00000018966.3 ENSMUST00000018966.4 ENSMUST00000018966.5 ENSMUST00000018966.6 ENSMUST00000018966.7 NM_018780 Sfrp5 uc008hnl.1 uc008hnl.2 uc008hnl.3 Belongs to the secreted frizzled-related protein (sFRP) family. Lacks conserved residue(s) required for the propagation of feature annotation. extracellular region multicellular organism development negative regulation of cell proliferation Wnt signaling pathway regulation of Wnt signaling pathway regulation of BMP signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of protein kinase B signaling negative regulation of canonical Wnt signaling pathway negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis uc008hnl.1 uc008hnl.2 uc008hnl.3 
ENSMUST00000018985.15 Rad51d ENSMUST00000018985.15 RAD51 paralog D, transcript variant 7 (from RefSeq NR_102718.1) ENSMUST00000018985.1 ENSMUST00000018985.10 ENSMUST00000018985.11 ENSMUST00000018985.12 ENSMUST00000018985.13 ENSMUST00000018985.14 ENSMUST00000018985.2 ENSMUST00000018985.3 ENSMUST00000018985.4 ENSMUST00000018985.5 ENSMUST00000018985.6 ENSMUST00000018985.7 ENSMUST00000018985.8 ENSMUST00000018985.9 NR_102718 Q3UGT8 Q3UGT8_MOUSE Rad51d Rad51l3 uc007knm.1 uc007knm.2 uc007knm.3 uc007knm.4 This gene belongs to the Rad51 gene family whose products play a major role in homologous recombination and DNA repair. The encoded protein interacts with other proteins of this family, including Rad51b, Rad51c and Xrcc2, and plays an essential role in both DNA repair and telomere maintenance. In humans, germline mutations in this gene may be associated with predisposition to ovarian cancer. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]. Nucleus four-way junction DNA binding telomere maintenance double-strand break repair via homologous recombination chromosome, telomeric region nuclear chromosome, telomeric region DNA binding single-stranded DNA binding ATP binding replication fork centrosome DNA repair DNA-dependent ATPase activity Rad51B-Rad51C-Rad51D-XRCC2 complex strand invasion gamma-tubulin binding uc007knm.1 uc007knm.2 uc007knm.3 uc007knm.4 
ENSMUST00000018988.6 Fndc8 ENSMUST00000018988.6 fibronectin type III domain containing 8 (from RefSeq NM_030224.1) ENSMUST00000018988.1 ENSMUST00000018988.2 ENSMUST00000018988.3 ENSMUST00000018988.4 ENSMUST00000018988.5 FNDC8_MOUSE NM_030224 Q8BUG1 Q9D2H8 uc007knr.1 uc007knr.2 uc007knr.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D2H8-1; Sequence=Displayed; Name=2; IsoId=Q9D2H8-2; Sequence=VSP_024559; molecular_function biological_process uc007knr.1 uc007knr.2 uc007knr.3 
ENSMUST00000018989.14 Unc45b ENSMUST00000018989.14 unc-45 myosin chaperone B, transcript variant 1 (from RefSeq NM_178680.5) Cmya4 ENSMUST00000018989.1 ENSMUST00000018989.10 ENSMUST00000018989.11 ENSMUST00000018989.12 ENSMUST00000018989.13 ENSMUST00000018989.2 ENSMUST00000018989.3 ENSMUST00000018989.4 ENSMUST00000018989.5 ENSMUST00000018989.6 ENSMUST00000018989.7 ENSMUST00000018989.8 ENSMUST00000018989.9 NM_178680 Q5XG72 Q8BHC5 Q8BWK3 Q8CGY6 UN45B_MOUSE uc007knv.1 uc007knv.2 uc007knv.3 uc007knv.4 Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development (PubMed:12356907, PubMed:18326487, PubMed:18478096). Is necessary for normal early lens development (By similarity). Interacts with HSP90 in an ATP-independent manner (PubMed:18326487, PubMed:18478096). Interacts with UBE4B; the interaction may target UNC45B for proteasomal degradation (By similarity). Cytoplasm, myofibril, sarcomere, Z line Cytoplasm, myofibril, sarcomere, A band Cytoplasm, perinuclear region Cytoplasm, cytosol Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CGY6-1; Sequence=Displayed; Name=2; IsoId=Q8CGY6-2; Sequence=VSP_020588; Highly expressed in adult skeletal muscle and heart. Detected at intermediate levels in lung. Highly expressed in embryonic heart. Detected in fusing myoblasts during muscle cell differentiation. Highly expressed in young myotubes that are in the process of assembling and remodeling myofibrils. Subsequently, levels decrease during myotube maturation. lens development in camera-type eye cytoplasm cytosol multicellular organism development muscle organ development cell differentiation Hsp90 protein binding chaperone-mediated protein folding uc007knv.1 uc007knv.2 uc007knv.3 uc007knv.4 
ENSMUST00000018990.8 Pank3 ENSMUST00000018990.8 pantothenate kinase 3 (from RefSeq NM_145962.2) ENSMUST00000018990.1 ENSMUST00000018990.2 ENSMUST00000018990.3 ENSMUST00000018990.4 ENSMUST00000018990.5 ENSMUST00000018990.6 ENSMUST00000018990.7 NM_145962 PANK3_MOUSE Q8R2W9 uc007ilf.1 uc007ilf.2 uc007ilf.3 Catalyzes the phosphorylation of pantothenate to generate 4'- phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Reaction=(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+); Xref=Rhea:RHEA:16373, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=2.7.1.33; Evidence= Subject to allosteric regulation, exists in two distinct conformational states, a catalytically incompetent (or open) conformation stabilized by the binding of acetyl(acyl)-CoA, and a catalytically competent (or closed) conformation stabilized by ATP- binding (By similarity). Acetyl-CoA and its thioesters act as allosteric inhibitors and compete with the ATP-binding site (By similarity). Strongly inhibited by acetyl-CoA, malonyl-CoA and palmitoyl CoA and modestly inhibited by CoA (PubMed:16040613). Inhibited by calcium hopantenate (PubMed:17379144). Kinetic parameters: KM=9.5 uM for pantothenate ; KM=112.0 uM for ATP ; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 1/5. Homodimer. Cytoplasm Highly expressed in the liver. Belongs to the type II pantothenate kinase family. nucleotide binding pantothenate kinase activity ATP binding nucleus cytoplasm cytosol coenzyme A biosynthetic process kinase activity phosphorylation transferase activity vitamin binding protein homodimerization activity acetyl-CoA binding uc007ilf.1 uc007ilf.2 uc007ilf.3 
ENSMUST00000018992.4 Rars1 ENSMUST00000018992.4 arginyl-tRNA synthetase 1 (from RefSeq NM_025936.3) ENSMUST00000018992.1 ENSMUST00000018992.2 ENSMUST00000018992.3 NM_025936 Q3THP2 Q3TM73 Q3U8R2 Q3U930 Q5SXA8 Q8VDW1 Q9D0I9 Rars SYRC_MOUSE uc007ilh.1 uc007ilh.2 uc007ilh.3 uc007ilh.4 Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:12060739). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1. Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl- tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA- COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215; EC=6.1.1.19; Evidence=; Interacts (via N-terminus) with AIMP1 (via N-terminus); this stimulates its catalytic activity. Interacts (via N-terminus) with LARS2 (via C-terminus). Monomer (By similarity). Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:12060739). Interacts with QARS1. Part of a complex composed of RARS1, QARS1 and AIMP1 (By similarity). Cytoplasm Cytoplasm, cytosol The alpha-helical N-terminus (residues 1-72) mediates interaction with AIMP1 and thereby contributes to the assembly of the multisynthetase complex. Belongs to the class-I aminoacyl-tRNA synthetase family. tRNA binding nucleotide binding aminoacyl-tRNA ligase activity arginine-tRNA ligase activity ATP binding nucleus nucleoplasm cytoplasm mitochondrion cytosol translation tRNA aminoacylation for protein translation arginyl-tRNA aminoacylation ligase activity aminoacyl-tRNA synthetase multienzyme complex arginine binding uc007ilh.1 uc007ilh.2 uc007ilh.3 uc007ilh.4 
ENSMUST00000018993.7 Wwc1 ENSMUST00000018993.7 WW, C2 and coiled-coil domain containing 1 (from RefSeq NM_170779.2) ENSMUST00000018993.1 ENSMUST00000018993.2 ENSMUST00000018993.3 ENSMUST00000018993.4 ENSMUST00000018993.5 ENSMUST00000018993.6 KIBRA_MOUSE Kiaa0869 NM_170779 Q571D0 Q5SXA9 Q8K1Y3 Q8VD17 Q922W3 uc007ili.1 uc007ili.2 uc007ili.3 Negative regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Modulates directional migration of podocytes. May be associated with memory performance (By similarity). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Plays an important role in regulating AMPA- selective glutamate receptors (AMPARs) trafficking (PubMed:31730661, PubMed:21943600). Homodimer. Forms heterodimers with WWC2 and WWC3. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with PATJ (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4 (By similarity). Interacts with CCDC141; retains AMPAR in the cytosol after internalization (PubMed:31730661). Interacts with DLC1 and PRKCZ (By similarity). Interacts (via WW domains) with LATS1 and LATS2 (By similarity). Cytoplasm toplasm, perinuclear region Nucleus Cell projection, ruffle membrane Cytoplasm, cytosol Note=Colocalizes with PRKCZ in the perinuclear region. Mammary epithelium. Expressed in mammary tissue throughout development (at protein level). Strongly up-regulated during pregnancy, falls during lactation and is again up-regulated during involution of the gland at weaning. The C2-domain mediates homodimerization. Phosphorylation at Ser-542 and Ser-923 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B. Deficient mice have significant deficits in hippocampal long-term potentiation (LTP) and long-term depression (LTD)vcand have profound learning and memory defects. Belongs to the WWC family. KIBRA subfamily. Sequence=AAH06733.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH37006.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter transcription coactivator activity nucleus cytoplasm cytosol plasma membrane membrane cell migration kinase binding protein binding, bridging ruffle membrane macromolecular complex regulation of hippo signaling negative regulation of hippo signaling cell projection positive regulation of MAPK cascade negative regulation of organ growth perinuclear region of cytoplasm binding, bridging positive regulation of nucleic acid-templated transcription uc007ili.1 uc007ili.2 uc007ili.3 
ENSMUST00000019012.4 Pnpla5 ENSMUST00000019012.4 patatin-like phospholipase domain containing 5 (from RefSeq NM_029427.1) ENSMUST00000019012.1 ENSMUST00000019012.2 ENSMUST00000019012.3 NM_029427 PLPL5_MOUSE Pnpla5 Q32LZ8 Q9D603 uc007xbv.1 uc007xbv.2 Has abundant triacylglycerol lipase activity. Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12045; Evidence=; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q32LZ8-1; Sequence=Displayed; Name=2; IsoId=Q32LZ8-2; Sequence=VSP_026374; triglyceride lipase activity cytoplasm lipid particle lipid metabolic process membrane lipid catabolic process hydrolase activity triglyceride catabolic process lipid homeostasis uc007xbv.1 uc007xbv.2 
ENSMUST00000019026.10 Mrpl45 ENSMUST00000019026.10 mitochondrial ribosomal protein L45 (from RefSeq NM_025927.4) ENSMUST00000019026.1 ENSMUST00000019026.2 ENSMUST00000019026.3 ENSMUST00000019026.4 ENSMUST00000019026.5 ENSMUST00000019026.6 ENSMUST00000019026.7 ENSMUST00000019026.8 ENSMUST00000019026.9 NM_025927 Q3TZL8 Q8VDW2 Q9D0Q7 RM45_MOUSE uc007ldx.1 uc007ldx.2 uc007ldx.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mL45 family. mitochondrion mitochondrial large ribosomal subunit ribosome biological_process uc007ldx.1 uc007ldx.2 uc007ldx.3 
ENSMUST00000019044.8 Slc22a5 ENSMUST00000019044.8 solute carrier family 22 (organic cation transporter), member 5, transcript variant 1 (from RefSeq NM_011396.4) ENSMUST00000019044.1 ENSMUST00000019044.2 ENSMUST00000019044.3 ENSMUST00000019044.4 ENSMUST00000019044.5 ENSMUST00000019044.6 ENSMUST00000019044.7 NM_011396 Octn2 Q9Z0E8 S22A5_MOUSE Slc22a5 uc007ixc.1 uc007ixc.2 uc007ixc.3 uc007ixc.4 Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine (PubMed:10454528, PubMed:20722056). Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3 (PubMed:10454528). May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). Reaction=(R)-carnitine(out) + Na(+)(out) = (R)-carnitine(in) + Na(+)(in); Xref=Rhea:RHEA:72091, ChEBI:CHEBI:16347, ChEBI:CHEBI:29101; Evidence= Reaction=glycine betaine(out) + Na(+)(out) = glycine betaine(in) + Na(+)(in); Xref=Rhea:RHEA:72115, ChEBI:CHEBI:17750, ChEBI:CHEBI:29101; Evidence=; Reaction=(R)-carnitine(in) + glycine betaine(out) = (R)-carnitine(out) + glycine betaine(in); Xref=Rhea:RHEA:72119, ChEBI:CHEBI:16347, ChEBI:CHEBI:17750; Evidence=; Reaction=Na(+)(out) + O-butanoyl-(R)-carnitine(out) = Na(+)(in) + O- butanoyl-(R)-carnitine(in); Xref=Rhea:RHEA:72123, ChEBI:CHEBI:21949, ChEBI:CHEBI:29101; Evidence=; Reaction=Na(+)(out) + O-acetyl-(R)-carnitine(out) = Na(+)(in) + O- acetyl-(R)-carnitine(in); Xref=Rhea:RHEA:72099, ChEBI:CHEBI:29101, ChEBI:CHEBI:57589; Evidence=; Reaction=Na(+)(out) + O-propanoyl-(R)-carnitine(out) = Na(+)(in) + O- propanoyl-(R)-carnitine(in); Xref=Rhea:RHEA:72103, ChEBI:CHEBI:29101, ChEBI:CHEBI:53210; Evidence=; Reaction=(S)-carnitine(out) + Na(+)(out) = (S)-carnitine(in) + Na(+)(in); Xref=Rhea:RHEA:72095, ChEBI:CHEBI:11060, ChEBI:CHEBI:29101; Evidence=; Reaction=Na(+)(out) + O-acyl-(R)-carnitine(out) = Na(+)(in) + O-acyl- (R)-carnitine(in); Xref=Rhea:RHEA:72107, ChEBI:CHEBI:29101, ChEBI:CHEBI:75659; Evidence=; Reaction=L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) = L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in); Xref=Rhea:RHEA:72111, ChEBI:CHEBI:29101, ChEBI:CHEBI:191852; Evidence=; Reaction=N,N-dimethylglycine(out) + Na(+)(out) = N,N- dimethylglycine(in) + Na(+)(in); Xref=Rhea:RHEA:76591, ChEBI:CHEBI:29101, ChEBI:CHEBI:58251; Evidence=; Inhibited by emetine, quinidine and verapamil. The IC(50) of emetine is 4.2 uM. Not inhibited by valproic acid. Transport of (R)-carnitine is stimulated by cholesterol in the plasma membrane. Interacts with PDZK1. Apical cell membrane ; Multi-pass membrane protein Basal cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Colocalizes with PDZK1 on apical membranes of kidney proximal tubules (PubMed:15523054). In intestinal cells, apical expression is induced by TNF (PubMed:20722056). Widely expressed. Expressed in kidney, liver and testis (PubMed:11010964). Expressed at the brush border of the small, large intestine and colon (at protein level) (PubMed:11010964, PubMed:20722056). Intestinal expression is induced by IFNG. Note=Defects in Slc22a5 are the cause of the juvenile visceral steatosis (JVS) phenotype. JVS is an autosomal recessive animal model of systemic carnitine deficiency. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. nucleotide binding ATP binding plasma membrane ion transport sodium ion transport mitochondrion organization adult heart development locomotory behavior carnitine metabolic process carnitine transmembrane transporter activity symporter activity quaternary ammonium group transmembrane transporter activity quaternary ammonium group transport carnitine transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane transmembrane transporter activity PDZ domain binding brush border membrane reproductive structure development quorum sensing involved in interaction with host transmembrane transport positive regulation of intestinal epithelial structure maintenance sodium-dependent organic cation transport carnitine transmembrane transport uc007ixc.1 uc007ixc.2 uc007ixc.3 uc007ixc.4 
ENSMUST00000019050.12 P4ha2 ENSMUST00000019050.12 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide, transcript variant 2 (from RefSeq NM_011031.2) ENSMUST00000019050.1 ENSMUST00000019050.10 ENSMUST00000019050.11 ENSMUST00000019050.2 ENSMUST00000019050.3 ENSMUST00000019050.4 ENSMUST00000019050.5 ENSMUST00000019050.6 ENSMUST00000019050.7 ENSMUST00000019050.8 ENSMUST00000019050.9 NM_011031 P4ha2 Q5SX75 Q5SX75_MOUSE uc007ixk.1 uc007ixk.2 uc007ixk.3 uc007ixk.4 Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Endoplasmic reticulum lumen Belongs to the P4HA family. procollagen-proline 4-dioxygenase activity iron ion binding collagen trimer nucleoplasm endoplasmic reticulum cytosol oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen peptidyl-proline hydroxylation L-ascorbic acid binding intracellular membrane-bounded organelle dioxygenase activity oxidation-reduction process uc007ixk.1 uc007ixk.2 uc007ixk.3 uc007ixk.4 
ENSMUST00000019051.3 Alox12e ENSMUST00000019051.3 arachidonate lipoxygenase, epidermal (from RefSeq NM_145684.2) Alox12e ENSMUST00000019051.1 ENSMUST00000019051.2 NM_145684 Q5F2E4 Q5F2E4_MOUSE uc007jun.1 uc007jun.2 uc007jun.3 Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Note=Binds 1 Fe cation per subunit. ; Lipid metabolism. Belongs to the lipoxygenase family. Lacks conserved residue(s) required for the propagation of feature annotation. iron ion binding oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen arachidonic acid metabolic process lipoxygenase pathway metal ion binding dioxygenase activity oxidation-reduction process uc007jun.1 uc007jun.2 uc007jun.3 
ENSMUST00000019058.6 Il3 ENSMUST00000019058.6 interleukin 3 (from RefSeq NM_010556.4) ENSMUST00000019058.1 ENSMUST00000019058.2 ENSMUST00000019058.3 ENSMUST00000019058.4 ENSMUST00000019058.5 Il3 NM_010556 Q5SX77 Q5SX77_MOUSE uc007ixn.1 uc007ixn.2 uc007ixn.3 Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage- restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK. Secreted Belongs to the IL-3 family. cytokine activity interleukin-3 receptor binding extracellular region extracellular space immune response signal transduction growth factor activity uc007ixn.1 uc007ixn.2 uc007ixn.3 
ENSMUST00000019060.6 Csf2 ENSMUST00000019060.6 colony stimulating factor 2 (granulocyte-macrophage) (from RefSeq NM_009969.4) Csf2 ENSMUST00000019060.1 ENSMUST00000019060.2 ENSMUST00000019060.3 ENSMUST00000019060.4 ENSMUST00000019060.5 NM_009969 Q5SX78 Q5SX78_MOUSE uc007ixm.1 uc007ixm.2 uc007ixm.3 Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Secreted Belongs to the GM-CSF family. cytokine activity granulocyte macrophage colony-stimulating factor receptor binding extracellular region extracellular space immune response signal transduction growth factor activity positive regulation of cell proliferation positive regulation of gene expression positive regulation of macrophage derived foam cell differentiation macrophage differentiation positive regulation of interleukin-23 production positive regulation of tyrosine phosphorylation of STAT protein myeloid dendritic cell differentiation intracellular membrane-bounded organelle negative regulation of transcription, DNA-templated negative regulation of cytolysis positive regulation of podosome assembly cellular response to granulocyte macrophage colony-stimulating factor stimulus dendritic cell differentiation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc007ixm.1 uc007ixm.2 uc007ixm.3 
ENSMUST00000019063.3 Tm4sf5 ENSMUST00000019063.3 transmembrane 4 superfamily member 5 (from RefSeq NM_029360.3) ENSMUST00000019063.1 ENSMUST00000019063.2 NM_029360 Q91XF2 Q91XF2_MOUSE Tm4sf5 uc007jvb.1 uc007jvb.2 uc007jvb.3 uc007jvb.4 uc007jvb.5 Membrane ; Multi- pass membrane protein Belongs to the L6 tetraspanin family. molecular_function lysosomal membrane plasma membrane biological_process membrane integral component of membrane arginine binding regulation of G1/S transition of mitotic cell cycle uc007jvb.1 uc007jvb.2 uc007jvb.3 uc007jvb.4 uc007jvb.5 
ENSMUST00000019064.9 Cxcl16 ENSMUST00000019064.9 C-X-C motif chemokine ligand 16, transcript variant 3 (from RefSeq NR_151497.1) CXL16_MOUSE ENSMUST00000019064.1 ENSMUST00000019064.2 ENSMUST00000019064.3 ENSMUST00000019064.4 ENSMUST00000019064.5 ENSMUST00000019064.6 ENSMUST00000019064.7 ENSMUST00000019064.8 NR_151497 Q3UD70 Q5F2D5 Q8BSU2 Q8VE25 Q9EPB3 Srpsox uc007juw.1 uc007juw.2 uc007juw.3 Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis. Membrane ; Single-pass type I membrane protein Widely expressed. Not detected in purified B- and T-cells. Glycosylated. Belongs to the intercrine alpha (chemokine CxC) family. low-density lipoprotein receptor activity scavenger receptor activity cytokine activity extracellular space receptor-mediated endocytosis chemotaxis signal transduction chemokine activity T cell chemotaxis membrane integral component of membrane positive regulation of cell growth positive regulation of cell migration response to cytokine response to interferon-gamma response to tumor necrosis factor chemokine receptor binding lymphocyte chemotaxis cellular response to lipopolysaccharide uc007juw.1 uc007juw.2 uc007juw.3 
ENSMUST00000019065.10 Pelp1 ENSMUST00000019065.10 proline, glutamic acid and leucine rich protein 1 (from RefSeq NM_029231.5) ENSMUST00000019065.1 ENSMUST00000019065.2 ENSMUST00000019065.3 ENSMUST00000019065.4 ENSMUST00000019065.5 ENSMUST00000019065.6 ENSMUST00000019065.7 ENSMUST00000019065.8 ENSMUST00000019065.9 Mnar NM_029231 PELP1_MOUSE Q5F2E2 Q6PEM0 Q91YM9 Q9DBD5 uc007jup.1 uc007jup.2 uc007jup.3 uc007jup.4 Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (By similarity). Interacts with HRS, RXRA, SUMO2, HDAC2, RB1 and STAT3. Interacts with PI3K, SRC and EGFR in cytoplasm. Interacts with ESR1, the interaction is enhanced by 17-beta-estradiol; the interaction increases ESR1 transcriptional activity (By similarity). Interacts with CREBBP and EP300 in a ligand-dependent manner (By similarity). Forms two complexes in the presence of 17-beta-estradiol; one with SRC and ESR1 and another with LCK and ESR1. Interacts with histone H1 and H3 with a greater affinity for H1. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Core component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9 (PubMed:22872859). Interacts with BCAS3 (By similarity). Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts (via PELP1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles (By similarity). Q9DBD5; P12813: Nr4a1; NbExp=3; IntAct=EBI-6909114, EBI-10896863; Nucleus, nucleolus Nucleus, nucleoplasm Nucleus toplasm te=Mainly found in the nucleoplasm, with low levels detected in the cytoplasm. Also found associated with the plasma membrane. Widely expressed with high levels in testis, ovary, uterus and pituitary gland. The Glu-rich region mediates histones interaction. The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1. Transiently sumoylated, preferentially conjugated to SUMO2 or SUMO3. Sumoylation causes nucleolar exclusion of PELP1 and promotes the recruitment of MDN1 to pre-60S particles. Desumoylation by SUMO isopeptidase SENP3 is needed to release both PELP1 and MDN1 from pre- ribosomes. Belongs to the RIX1/PELP1 family. chromatin binding protein binding nucleus nucleoplasm nucleolus cytoplasm transcription factor binding transcriptionally active chromatin positive regulation of transcription from RNA polymerase II promoter MLL1 complex cellular response to estrogen stimulus uc007jup.1 uc007jup.2 uc007jup.3 uc007jup.4 
ENSMUST00000019067.8 Med11 ENSMUST00000019067.8 mediator complex subunit 11 (from RefSeq NM_025397.3) ENSMUST00000019067.1 ENSMUST00000019067.2 ENSMUST00000019067.3 ENSMUST00000019067.4 ENSMUST00000019067.5 ENSMUST00000019067.6 ENSMUST00000019067.7 MED11_MOUSE NM_025397 Q3V4D0 Q9D8C6 uc007juv.1 uc007juv.2 uc007juv.3 uc007juv.4 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Q9D8C6; Q9NVC6: MED17; Xeno; NbExp=2; IntAct=EBI-6260909, EBI-394562; Q9D8C6; Q15528: MED22; Xeno; NbExp=2; IntAct=EBI-6260909, EBI-394687; Q9D8C6; Q9H204: MED28; Xeno; NbExp=2; IntAct=EBI-6260909, EBI-514199; Q9D8C6; Q9NX70: MED29; Xeno; NbExp=2; IntAct=EBI-6260909, EBI-394656; Nucleus Expressed in cochlea. Belongs to the Mediator complex subunit 11 family. ubiquitin ligase complex transcription cofactor activity protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter biological_process protein ubiquitination mediator complex ubiquitin protein ligase activity uc007juv.1 uc007juv.2 uc007juv.3 uc007juv.4 
ENSMUST00000019068.7 Alox15 ENSMUST00000019068.7 arachidonate 15-lipoxygenase (from RefSeq NM_009660.3) Alox12l Alox15 ENSMUST00000019068.1 ENSMUST00000019068.2 ENSMUST00000019068.3 ENSMUST00000019068.4 ENSMUST00000019068.5 ENSMUST00000019068.6 LOX15_MOUSE NM_009660 P39654 Q4FJY9 Q5F2E3 Q6PHB2 uc007juo.1 uc007juo.2 uc007juo.3 Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:8188678). It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12- hydroperoxyeicosatetraenoate/12-HPETE and 15- hydroperoxyeicosatetraenoate/15-HPETE (PubMed:8188678). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)- octadecadienoate) to 13-hydroperoxyoctadecadienoate. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)- docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (By similarity). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response (PubMed:22503541). In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties (PubMed:15708862). Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells (PubMed:11278875). It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function (PubMed:10432118). It may also exert a negative effect on skeletal development by regulating bone mass through this pathway (PubMed:14716014). As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (PubMed:22215650). Finally, it is also involved in the cellular response to IL13/interleukin-13 (By similarity). Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy- (5Z,8Z,10E,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:10428, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57444; EC=1.13.11.31; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10429; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy- (5Z,8Z,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:16869, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57446; EC=1.13.11.33; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16870; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)- octadecadienoate; Xref=Rhea:RHEA:22780, ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:57466; EC=1.13.11.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22781; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)- dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate; Xref=Rhea:RHEA:50928, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:133900; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50929; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)- dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:50924, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:133899; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50925; Evidence=; Reaction=(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (8S)- hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate; Xref=Rhea:RHEA:50288, ChEBI:CHEBI:15379, ChEBI:CHEBI:131964, ChEBI:CHEBI:132068; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50289; Evidence=; Reaction=(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)- hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate; Xref=Rhea:RHEA:50284, ChEBI:CHEBI:15379, ChEBI:CHEBI:131964, ChEBI:CHEBI:132065; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50285; Evidence=; Reaction=(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (5S)- hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:50280, ChEBI:CHEBI:15379, ChEBI:CHEBI:131965, ChEBI:CHEBI:132067; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50281; Evidence=; Reaction=(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)- hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate; Xref=Rhea:RHEA:50276, ChEBI:CHEBI:15379, ChEBI:CHEBI:131965, ChEBI:CHEBI:132063; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50277; Evidence=; Reaction=(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo- (5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:50152, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:82626; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50153; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:50140, ChEBI:CHEBI:15377, ChEBI:CHEBI:57446, ChEBI:CHEBI:132070; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50141; Evidence=; Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8S)- hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate; Xref=Rhea:RHEA:50216, ChEBI:CHEBI:57444, ChEBI:CHEBI:132129; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50217; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = 14-hydroperoxy- (4Z,7Z,10Z,12E,16Z)-docosapentaenoate; Xref=Rhea:RHEA:50824, ChEBI:CHEBI:15379, ChEBI:CHEBI:77226, ChEBI:CHEBI:133799; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50825; Evidence=; Reaction=(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy- (7Z,10Z,12E,16Z,19Z)-docosapentaenoate; Xref=Rhea:RHEA:50836, ChEBI:CHEBI:15379, ChEBI:CHEBI:77224, ChEBI:CHEBI:133798; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50837; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)- hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate; Xref=Rhea:RHEA:41332, ChEBI:CHEBI:15379, ChEBI:CHEBI:77016, ChEBI:CHEBI:78048; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41333; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)- hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate; Xref=Rhea:RHEA:50840, ChEBI:CHEBI:15379, ChEBI:CHEBI:77016, ChEBI:CHEBI:133795; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50841; Evidence=; Reaction=(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate; Xref=Rhea:RHEA:64724, ChEBI:CHEBI:15379, ChEBI:CHEBI:156049, ChEBI:CHEBI:156082; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64725; Evidence=; Reaction=(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate; Xref=Rhea:RHEA:64728, ChEBI:CHEBI:15379, ChEBI:CHEBI:140349, ChEBI:CHEBI:156049; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64729; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (11S)- hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate; Xref=Rhea:RHEA:64732, ChEBI:CHEBI:15379, ChEBI:CHEBI:77016, ChEBI:CHEBI:156131; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64733; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(12S)- hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine; Xref=Rhea:RHEA:50160, ChEBI:CHEBI:15379, ChEBI:CHEBI:132060, ChEBI:CHEBI:132061; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50161; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma- aminobutanoate; Xref=Rhea:RHEA:50176, ChEBI:CHEBI:15379, ChEBI:CHEBI:132072, ChEBI:CHEBI:132075; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50177; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)- hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine; Xref=Rhea:RHEA:50168, ChEBI:CHEBI:15379, ChEBI:CHEBI:59002, ChEBI:CHEBI:132073; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50169; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(12S)- hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine; Xref=Rhea:RHEA:50172, ChEBI:CHEBI:15379, ChEBI:CHEBI:132071, ChEBI:CHEBI:132074; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50173; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)- hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine; Xref=Rhea:RHEA:50156, ChEBI:CHEBI:15379, ChEBI:CHEBI:132060, ChEBI:CHEBI:132062; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50157; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma- aminobutanoate; Xref=Rhea:RHEA:50180, ChEBI:CHEBI:15379, ChEBI:CHEBI:132072, ChEBI:CHEBI:132078; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50181; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)- hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine; Xref=Rhea:RHEA:50188, ChEBI:CHEBI:15379, ChEBI:CHEBI:59002, ChEBI:CHEBI:132076; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50189; Evidence=; Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(15S)- hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine; Xref=Rhea:RHEA:50184, ChEBI:CHEBI:15379, ChEBI:CHEBI:132071, ChEBI:CHEBI:132077; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50185; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence= Note=Binds 1 Fe cation per subunit. Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. Interacts with PEBP1; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade. Cytoplasm, cytosol Cell membrane ; Peripheral membrane protein Lipid droplet Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding (PubMed:11278875). Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells (PubMed:11278875). Found in pituitary and pineal glands as well as leukocytes, kidney, aorta, small intestine and cornea (PubMed:15708862, PubMed:22503541, PubMed:8188678). Also expressed by resident peritoneal macrophages (at protein level) (PubMed:8798642). Up-regulated in response to endoplasmic reticulum stress (at protein level). The PLAT domain can bind calcium ions; this promotes association with membranes. Mice are fertile and do not display overt phenotype. However, reduced endoplasmic reticulum stress response to high-fat diet is observed. Aged mice also display systemic autoimmunity, a significant and spontaneous production of several forms of autoantibodies being detected and glomerulonephritis and deposits of complement and immunoglobulins within their glomeruli being observed. They also display reduced bone mass. Belongs to the lipoxygenase family. ossification negative regulation of adaptive immune response arachidonate 12-lipoxygenase activity iron ion binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm lipid particle cytosol plasma membrane lipid metabolic process fatty acid metabolic process phosphatidylethanolamine biosynthetic process lipid binding positive regulation of cell-substrate adhesion membrane oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen arachidonic acid metabolic process lipoxygenase pathway bone mineralization positive regulation of actin filament polymerization extrinsic component of cytoplasmic side of plasma membrane positive regulation of heterotypic cell-cell adhesion response to endoplasmic reticulum stress regulation of peroxisome proliferator activated receptor signaling pathway cellular response to interleukin-13 wound healing apoptotic cell clearance metal ion binding hepoxilin-epoxide hydrolase activity arachidonate 15-lipoxygenase activity hepoxilin A3 synthase activity hepoxilin biosynthetic process dioxygenase activity oxidation-reduction process positive regulation of ERK1 and ERK2 cascade cellular response to calcium ion regulation of engulfment of apoptotic cell lipoxin A4 biosynthetic process uc007juo.1 uc007juo.2 uc007juo.3 
ENSMUST00000019069.4 Heatr9 ENSMUST00000019069.4 HEAT repeat containing 9 (from RefSeq NM_001045543.2) ENSMUST00000019069.1 ENSMUST00000019069.2 ENSMUST00000019069.3 Gm11435 HEAT9_MOUSE NM_001045543 Q5QNV8 uc007kph.1 uc007kph.2 uc007kph.3 uc007kph.4 Despite its name, the presence of HEAT repeat is unsure and is not confirmed by repeat-detection programs. hematopoietic progenitor cell differentiation cellular_component uc007kph.1 uc007kph.2 uc007kph.3 uc007kph.4 
ENSMUST00000019071.4 Ccl6 ENSMUST00000019071.4 C-C motif chemokine ligand 6 (from RefSeq NM_009139.3) C10 CCL6_MOUSE ENSMUST00000019071.1 ENSMUST00000019071.2 ENSMUST00000019071.3 NM_009139 P27784 Q3U3W3 Q5QNW1 Q99M24 Q9D830 Scya6 uc007kpm.1 uc007kpm.2 uc007kpm.3 Chemotactic factor that attracts mostly macrophage, but it can also attract B cells, CD4(+) lymphocytes and eosinophils. Secreted. Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF. Associated with stimuli that promote myeloid differentiation. The N-terminal is proteolytically cleaved by proteases associated with inflammatory responses. The processed forms CL6(22-95) and CCL6(23-95) show increase in CCR1-mediated signaling and chemotaxis assays in vitro. Belongs to the intercrine beta (chemokine CC) family. monocyte chemotaxis cytokine activity extracellular region extracellular space chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway chemokine activity neutrophil chemotaxis positive regulation of GTPase activity CCR chemokine receptor binding eosinophil chemotaxis lymphocyte chemotaxis cell chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor uc007kpm.1 uc007kpm.2 uc007kpm.3 
ENSMUST00000019074.4 Ccl4 ENSMUST00000019074.4 C-C motif chemokine ligand 4 (from RefSeq NM_013652.2) Ccl4 ENSMUST00000019074.1 ENSMUST00000019074.2 ENSMUST00000019074.3 NM_013652 Q5QNV9 Q5QNV9_MOUSE uc007kpp.1 uc007kpp.2 Secreted Belongs to the intercrine beta (chemokine CC) family. cytokine activity extracellular region extracellular space chemotaxis immune response signal transduction chemokine activity cell chemotaxis uc007kpp.1 uc007kpp.2 
ENSMUST00000019075.4 Natd1 ENSMUST00000019075.4 N-acetyltransferase domain containing 1 (from RefSeq NM_025294.5) ENSMUST00000019075.1 ENSMUST00000019075.2 ENSMUST00000019075.3 Gm16515 Gtlf3b NATD1_MOUSE NM_025294 Q9DBW3 uc007jgu.1 uc007jgu.2 uc007jgu.3 uc007jgu.4 Expressed in the heart, testis, kidney and lung. Detected at multiple sites in embryonic day 10.5 embryos, including the genital ridges, the aortic endothelium and endothelium-associated cell clusters within the aortic lumen. Belongs to the NATD1 family. cellular_component uc007jgu.1 uc007jgu.2 uc007jgu.3 uc007jgu.4 
ENSMUST00000019076.10 Map2k3 ENSMUST00000019076.10 mitogen-activated protein kinase kinase 3, transcript variant 1 (from RefSeq NM_008928.5) ENSMUST00000019076.1 ENSMUST00000019076.2 ENSMUST00000019076.3 ENSMUST00000019076.4 ENSMUST00000019076.5 ENSMUST00000019076.6 ENSMUST00000019076.7 ENSMUST00000019076.8 ENSMUST00000019076.9 Map2k3 NM_008928 Q5SWN9 Q5SWN9_MOUSE uc007jgx.1 uc007jgx.2 uc007jgx.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation protein kinase binding cellular response to vascular endothelial growth factor stimulus p38MAPK cascade positive regulation of blood vessel endothelial cell migration positive regulation of protein kinase activity positive regulation of transcription, DNA-templated uc007jgx.1 uc007jgx.2 uc007jgx.3 
ENSMUST00000019109.8 Ywhah ENSMUST00000019109.8 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide (from RefSeq NM_011738.2) 1433F_MOUSE ENSMUST00000019109.1 ENSMUST00000019109.2 ENSMUST00000019109.3 ENSMUST00000019109.4 ENSMUST00000019109.5 ENSMUST00000019109.6 ENSMUST00000019109.7 NM_011738 P11576 P68510 P70198 Q3TGZ9 uc008xag.1 uc008xag.2 uc008xag.3 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weakly interacts with CDKN1B (By similarity). Interacts with ARHGEF28 and CDK16. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1. Interacts with the 'Ser-241' phosphorylated form of PDPK1 (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with SLITRK1 (By similarity). Interacts with MEFV (By similarity). P68510; Q5S006: Lrrk2; NbExp=7; IntAct=EBI-444641, EBI-2693710; P68510; Q9WVS6: Prkn; NbExp=2; IntAct=EBI-444641, EBI-973635; P68510; O60260: PRKN; Xeno; NbExp=6; IntAct=EBI-444641, EBI-716346; P68510; P21580: TNFAIP3; Xeno; NbExp=3; IntAct=EBI-444641, EBI-527670; Cytoplasm. Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Belongs to the 14-3-3 family. regulation of sodium ion transport actin binding protein binding cytoplasm cytosol plasma membrane glucocorticoid catabolic process intracellular protein transport cytoskeleton organization regulation of mitotic nuclear division intercalated disc sodium channel regulator activity enzyme binding protein domain specific binding glucocorticoid receptor binding identical protein binding glucocorticoid receptor signaling pathway negative regulation of apoptotic process ion channel binding synapse positive regulation of transcription, DNA-templated protein heterodimerization activity negative regulation of dendrite morphogenesis membrane depolarization during action potential regulation of sodium ion transmembrane transporter activity uc008xag.1 uc008xag.2 uc008xag.3 
ENSMUST00000019117.3 Hoxb1 ENSMUST00000019117.3 homeobox B1 (from RefSeq NM_008266.6) ENSMUST00000019117.1 ENSMUST00000019117.2 HXB1_MOUSE Hox-2.9 Hoxb-1 NM_008266 P17919 Q3ZAY6 Q9CYH3 uc007lbz.1 uc007lbz.2 uc007lbz.3 uc007lbz.4 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Nucleus. Expressed along the entire length of the primitive streak. In early neurogenesis it is expressed in lateral and paraxial mesoderm, endoderm and superficial ectoderm or in the neural tube. From late neurogenesis to mid-embryogenesis, it presents similar spatial domains in the lateral mesoderm, endoderm and superficial ectoderm but is not detectable in the posterior hindbrain and has increased dramatically in rhombomere 4. Belongs to the Antp homeobox family. Labial subfamily. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development anatomical structure morphogenesis anterior/posterior pattern specification protein domain specific binding rhombomere development rhombomere 4 development rhombomere 5 development facial nerve structural organization facial nucleus development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter anatomical structure formation involved in morphogenesis embryonic skeletal system morphogenesis uc007lbz.1 uc007lbz.2 uc007lbz.3 uc007lbz.4 
ENSMUST00000019118.8 Sart3 ENSMUST00000019118.8 squamous cell carcinoma antigen recognized by T cells 3, transcript variant 2 (from RefSeq NM_016926.2) ENSMUST00000019118.1 ENSMUST00000019118.2 ENSMUST00000019118.3 ENSMUST00000019118.4 ENSMUST00000019118.5 ENSMUST00000019118.6 ENSMUST00000019118.7 Kiaa0156 NM_016926 Q6ZQI2 Q8BPK9 Q8C3B7 Q8CFU9 Q9JLI8 SART3_MOUSE Sart3 uc008yym.1 uc008yym.2 uc008yym.3 U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri- snRNP spliceosomal complex disassembly. May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (By similarity). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (PubMed:21447833). Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with AGO1 and AGO2. Interacts with PRPF3 and USP4; the interaction with PRPF3 is direct and recruits USP4 to its substrate PRPF3. Interacts with USP15; the interaction is direct. Nucleus, nucleoplasm Nucleus, Cajal body Nucleus speckle Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JLI8-1; Sequence=Displayed; Name=2; IsoId=Q9JLI8-2; Sequence=VSP_017252, VSP_017253; Ubiquitously expressed, with low level of expression in liver, heart and skeletal (PubMed:10761712). Also detected in hematopoietic cells (at protein level) (PubMed:21447833). Expressed from early prenatal stages, as early as 7 dpc and increased thereafter. Up-regulated in proliferating hematopoietic cells. Knockout of Sart3 is embryonic lethal. Sequence=AAH36350.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; spliceosomal tri-snRNP complex assembly regulation of alternative mRNA splicing, via spliceosome spliceosomal snRNP assembly mRNA splicing, via spliceosome cell morphogenesis nucleic acid binding RNA binding nucleus nucleoplasm cytoplasm nucleosome assembly RNA processing mRNA processing RNA splicing regulation of gene expression Cajal body nuclear speck U6 snRNA binding U6atac snRNA binding histone binding homeostasis of number of cells ASAP complex hematopoietic stem cell proliferation positive regulation of histone deubiquitination ubiquitin-specific protease binding U6atac snRNP U4/U6 snRNP uc008yym.1 uc008yym.2 uc008yym.3 
ENSMUST00000019143.9 Slc35b4 ENSMUST00000019143.9 solute carrier family 35, member B4, transcript variant 2 (from RefSeq NR_184551.1) ENSMUST00000019143.1 ENSMUST00000019143.2 ENSMUST00000019143.3 ENSMUST00000019143.4 ENSMUST00000019143.5 ENSMUST00000019143.6 ENSMUST00000019143.7 ENSMUST00000019143.8 MNCb-4414 NR_184551 Q3TQU7 Q5U681 Q8CIA5 Q9JJF7 S35B4_MOUSE uc009bgx.1 uc009bgx.2 uc009bgx.3 Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for another nucleotide sugar. May couple UDP-alpha-D-glucuronate (UDP-GlcA) or UDP-alpha-D- xylose (UDP-Xyl) efflux to UDP-alpha-D-glucuronate (UDP-GlcA) influx into the ER lumen, which in turn stimulates glucuronidation and excretion of endobiotics and xenobiotics. Reaction=UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D- glucosamine(in) = UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D- glucosamine(out); Xref=Rhea:RHEA:73703, ChEBI:CHEBI:57705, ChEBI:CHEBI:58052; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73704; Evidence=; Reaction=UDP-alpha-D-glucuronate(out) + UDP-alpha-D-xylose(in) = UDP- alpha-D-glucuronate(in) + UDP-alpha-D-xylose(out); Xref=Rhea:RHEA:74831, ChEBI:CHEBI:57632, ChEBI:CHEBI:58052; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74832; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CIA5-1; Sequence=Displayed; Name=2; IsoId=Q8CIA5-2; Sequence=VSP_016203; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. Golgi membrane UDP-N-acetylglucosamine transmembrane transporter activity UDP-xylose transmembrane transporter activity endoplasmic reticulum Golgi apparatus regulation of gluconeogenesis carbohydrate transport UDP-xylose transport membrane integral component of membrane transmembrane transporter activity integral component of Golgi membrane integral component of endoplasmic reticulum membrane transmembrane transport UDP-N-acetylglucosamine transmembrane transport uc009bgx.1 uc009bgx.2 uc009bgx.3 
ENSMUST00000019183.14 Dalrd3 ENSMUST00000019183.14 DALR anticodon binding domain containing 3 (from RefSeq NM_026378.3) DALD3_MOUSE ENSMUST00000019183.1 ENSMUST00000019183.10 ENSMUST00000019183.11 ENSMUST00000019183.12 ENSMUST00000019183.13 ENSMUST00000019183.2 ENSMUST00000019183.3 ENSMUST00000019183.4 ENSMUST00000019183.5 ENSMUST00000019183.6 ENSMUST00000019183.7 ENSMUST00000019183.8 ENSMUST00000019183.9 NM_026378 Q6PJN8 Q8C1T1 Q9D1L6 uc009rqi.1 uc009rqi.2 uc009rqi.3 Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)- methylcytidine modification by METTL2. Part of a complex containing tRNA(Arg) and METTL2. Interacts with tRNA(Arg)(CCU) and tRNA(Arg)(UCU). Interacts with METTL2. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PJN8-1; Sequence=Displayed; Name=2; IsoId=Q6PJN8-2; Sequence=VSP_030747; nucleotide binding aminoacyl-tRNA ligase activity arginine-tRNA ligase activity ATP binding cellular_component tRNA aminoacylation for protein translation arginyl-tRNA aminoacylation biological_process uc009rqi.1 uc009rqi.2 uc009rqi.3 
ENSMUST00000019198.7 Fis1 ENSMUST00000019198.7 fission, mitochondrial 1, transcript variant 1 (from RefSeq NM_025562.3) ENSMUST00000019198.1 ENSMUST00000019198.2 ENSMUST00000019198.3 ENSMUST00000019198.4 ENSMUST00000019198.5 ENSMUST00000019198.6 FIS1_MOUSE NM_025562 Q9CQ92 Ttc11 uc009abf.1 uc009abf.2 uc009abf.3 Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:23283981). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (PubMed:23283981). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (By similarity). Also mediates peroxisomal fission (By similarity). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (By similarity). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity). Interacts with DNM1L/DLP1 through the TPR region; may form part of a larger protein complex at the endoplasmic reticulum- mitochondrial interface during mitochondrial fission (By similarity). Interacts with MARCHF5 (By similarity). Interacts with MIEF1 (By similarity). Interacts with PEX11A, PEX11B and PEX11G (By similarity). Mitochondrion outer membrane ; Single-pass membrane protein Peroxisome membrane ; Single-pass membrane protein The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L. Ubiquitinated by MARCHF5. Belongs to the FIS1 family. mitochondrial fission mitophagy release of cytochrome c from mitochondria mitochondrion mitochondrial outer membrane peroxisome peroxisomal membrane integral component of peroxisomal membrane endoplasmic reticulum protein targeting to mitochondrion apoptotic process positive regulation of cytosolic calcium ion concentration mitochondrial fusion regulation of mitochondrion organization membrane integral component of membrane peroxisome fission integral component of mitochondrial outer membrane negative regulation of endoplasmic reticulum calcium ion concentration macromolecular complex calcium-mediated signaling using intracellular calcium source positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of neuron apoptotic process mitochondrial fragmentation involved in apoptotic process macromolecular complex binding protein homooligomerization positive regulation of mitochondrial calcium ion concentration mitochondrion morphogenesis positive regulation of mitochondrial fission positive regulation of protein targeting to membrane cellular response to peptide cellular response to thapsigargin positive regulation of intrinsic apoptotic signaling pathway uc009abf.1 uc009abf.2 uc009abf.3 
ENSMUST00000019199.14 Plod1 ENSMUST00000019199.14 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (from RefSeq NM_011122.3) ENSMUST00000019199.1 ENSMUST00000019199.10 ENSMUST00000019199.11 ENSMUST00000019199.12 ENSMUST00000019199.13 ENSMUST00000019199.2 ENSMUST00000019199.3 ENSMUST00000019199.4 ENSMUST00000019199.5 ENSMUST00000019199.6 ENSMUST00000019199.7 ENSMUST00000019199.8 ENSMUST00000019199.9 NM_011122 PLOD1_MOUSE Plod Q9R0E2 uc008vtk.1 uc008vtk.2 uc008vtk.3 uc008vtk.4 Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (PubMed:27119146). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (PubMed:27119146). Reaction=2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L- lysyl-[collagen] + CO2 + succinate; Xref=Rhea:RHEA:16569, Rhea:RHEA- COMP:12751, Rhea:RHEA-COMP:12752, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:133442; EC=1.14.11.4; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Homodimer (By similarity). Identified in a complex with P3H3 and P3H4 (PubMed:27119146). Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Highly expressed in the liver, heart, lung, skeletal muscle and kidney. response to hypoxia iron ion binding protein binding endoplasmic reticulum ferrous iron binding procollagen-lysine 5-dioxygenase activity epidermis development membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen peptidyl-lysine hydroxylation collagen fibril organization rough endoplasmic reticulum membrane L-ascorbic acid binding collagen metabolic process peptide binding metal ion binding hydroxylysine biosynthetic process dioxygenase activity oxidation-reduction process catalytic complex uc008vtk.1 uc008vtk.2 uc008vtk.3 uc008vtk.4 
ENSMUST00000019220.16 Strn4 ENSMUST00000019220.16 striatin, calmodulin binding protein 4, transcript variant 1 (from RefSeq NM_133789.3) E9QKX6 ENSMUST00000019220.1 ENSMUST00000019220.10 ENSMUST00000019220.11 ENSMUST00000019220.12 ENSMUST00000019220.13 ENSMUST00000019220.14 ENSMUST00000019220.15 ENSMUST00000019220.2 ENSMUST00000019220.3 ENSMUST00000019220.4 ENSMUST00000019220.5 ENSMUST00000019220.6 ENSMUST00000019220.7 ENSMUST00000019220.8 ENSMUST00000019220.9 NM_133789 P58404 Q68EF5 STRN4_MOUSE Zin uc009fif.1 uc009fif.2 uc009fif.3 Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN4. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity). Interacts with CTTNBP2NL (By similarity). Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, dendritic spine Note=CTTNBP2-binding may regulate dendritic spine distribution. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P58404-1; Sequence=Displayed; Name=2; IsoId=P58404-2; Sequence=VSP_013815; Mainly expressed in brain but is also expressed at low levels in the kidney. The name 'Zinedin' probably originates from the name of the famous soccer player from Marseille (Zinedine Zidane). Belongs to the WD repeat striatin family. calmodulin binding cytoplasm biological_process membrane protein domain specific binding dendrite macromolecular complex cell projection dendritic spine macromolecular complex binding protein phosphatase 2A binding armadillo repeat domain binding FAR/SIN/STRIPAK complex uc009fif.1 uc009fif.2 uc009fif.3 
ENSMUST00000019224.9 Mfsd3 ENSMUST00000019224.9 major facilitator superfamily domain containing 3 (from RefSeq NM_027122.3) A0A0R4J004 A0A0R4J004_MOUSE ENSMUST00000019224.1 ENSMUST00000019224.2 ENSMUST00000019224.3 ENSMUST00000019224.4 ENSMUST00000019224.5 ENSMUST00000019224.6 ENSMUST00000019224.7 ENSMUST00000019224.8 Mfsd3 NM_027122 uc007wlt.1 uc007wlt.2 uc007wlt.3 Membrane ; Multi- pass membrane protein integral component of plasma membrane membrane integral component of membrane transmembrane transport uc007wlt.1 uc007wlt.2 uc007wlt.3 
ENSMUST00000019226.14 Slc25a22 ENSMUST00000019226.14 solute carrier family 25 (mitochondrial carrier, glutamate), member 22, transcript variant 1 (from RefSeq NM_026646.3) ENSMUST00000019226.1 ENSMUST00000019226.10 ENSMUST00000019226.11 ENSMUST00000019226.12 ENSMUST00000019226.13 ENSMUST00000019226.2 ENSMUST00000019226.3 ENSMUST00000019226.4 ENSMUST00000019226.5 ENSMUST00000019226.6 ENSMUST00000019226.7 ENSMUST00000019226.8 ENSMUST00000019226.9 GHC1_MOUSE Gc1 NM_026646 Q3TRY1 Q9D6M3 uc009kla.1 uc009kla.2 uc009kla.3 uc009kla.4 Mitochondrial glutamate/H(+) symporter. Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (By similarity). Plays a role in the control of glucose-stimulated insulin secretion (By similarity). Reaction=H(+)(in) + L-glutamate(in) = H(+)(out) + L-glutamate(out); Xref=Rhea:RHEA:70955, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. L-glutamate transmembrane transporter activity mitochondrion mitochondrial inner membrane L-aspartate transmembrane transporter activity symporter activity aspartate transport L-glutamate transport membrane integral component of membrane transmembrane transporter activity malate-aspartate shuttle transmembrane transport L-aspartate transport uc009kla.1 uc009kla.2 uc009kla.3 uc009kla.4 
ENSMUST00000019229.15 Med8 ENSMUST00000019229.15 mediator complex subunit 8, transcript variant 1 (from RefSeq NM_020000.3) ENSMUST00000019229.1 ENSMUST00000019229.10 ENSMUST00000019229.11 ENSMUST00000019229.12 ENSMUST00000019229.13 ENSMUST00000019229.14 ENSMUST00000019229.2 ENSMUST00000019229.3 ENSMUST00000019229.4 ENSMUST00000019229.5 ENSMUST00000019229.6 ENSMUST00000019229.7 ENSMUST00000019229.8 ENSMUST00000019229.9 MED8_MOUSE MNCb-2386 NM_020000 Q3UGB4 Q99LM4 Q9D7W5 Q9JJ84 uc008ujw.1 uc008ujw.2 uc008ujw.3 uc008ujw.4 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Protein modification; protein ubiquitination. Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. May be part of a multisubunit E3 ubiquitin-protein ligase complex with the Elongin BC complex (ELOB and ELOC), CUL2 and RBX1 (By similarity). Q9D7W5; Q9R0X0: Med20; NbExp=2; IntAct=EBI-7990252, EBI-398698; Q9D7W5; Q9CQI9: Med30; NbExp=2; IntAct=EBI-7990252, EBI-309220; Q9D7W5; Q9NVC6: MED17; Xeno; NbExp=2; IntAct=EBI-7990252, EBI-394562; Q9D7W5; Q15528: MED22; Xeno; NbExp=2; IntAct=EBI-7990252, EBI-394687; Q9D7W5; Q6P2C8: MED27; Xeno; NbExp=2; IntAct=EBI-7990252, EBI-394603; Q9D7W5; Q9H204: MED28; Xeno; NbExp=2; IntAct=EBI-7990252, EBI-514199; Q9D7W5; Q9NX70: MED29; Xeno; NbExp=2; IntAct=EBI-7990252, EBI-394656; Q9D7W5; O75586: MED6; Xeno; NbExp=2; IntAct=EBI-7990252, EBI-394624; Nucleus Belongs to the Mediator complex subunit 8 family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription cofactor activity protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter protein ubiquitination mediator complex core mediator complex uc008ujw.1 uc008ujw.2 uc008ujw.3 uc008ujw.4 
ENSMUST00000019231.12 Atp6ap1 ENSMUST00000019231.12 ATPase, H+ transporting, lysosomal accessory protein 1, transcript variant 1 (from RefSeq NM_018794.5) Atp6ip1 Atp6s1 ENSMUST00000019231.1 ENSMUST00000019231.10 ENSMUST00000019231.11 ENSMUST00000019231.2 ENSMUST00000019231.3 ENSMUST00000019231.4 ENSMUST00000019231.5 ENSMUST00000019231.6 ENSMUST00000019231.7 ENSMUST00000019231.8 ENSMUST00000019231.9 NM_018794 Q9R1Q9 VAS1_MOUSE uc009tol.1 uc009tol.2 uc009tol.3 Accessory subunit of the proton-transporting vacuolar (V)- ATPase protein pump, which is required for luminal acidification of secretory vesicles (PubMed:18713856). Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)- dependent membrane fusion. May play a role in the assembly of the V- type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules (PubMed:18713856). Accessory component of the multisubunit proton-transporting vacuolar (V)-ATPase protein pump. Interacts (via N-terminus) with ATP6AP2 (via N-terminus). Interacts with RNASEK (By similarity). Interacts with TMEM106B (via C-terminus) (By similarity). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Single-pass type I membrane protein Note=Not detected in trans-Golgi network. Expressed in brain cortex (at protein level) (PubMed:27231034). Highly expressed in islets of Langerhans (PubMed:18713856). Expressed in pancreatic acini, pituitary gland, adrenal gland, lung, brain and bone marrow (PubMed:18713856). N-glycosylated. Belongs to the vacuolar ATPase subunit S1 family. nucleotide binding ATP binding endoplasmic reticulum endoplasmic reticulum membrane ion transport cellular iron ion homeostasis cell death membrane integral component of membrane Rab GTPase binding regulation of cellular pH endoplasmic reticulum-Golgi intermediate compartment membrane proton-transporting V-type ATPase, V1 domain plasma membrane proton-transporting V-type ATPase complex cellular response to increased oxygen levels positive regulation of osteoblast differentiation positive regulation of bone resorption pH reduction positive regulation of exocytosis proton-transporting ATP synthase activity, rotational mechanism proton-transporting ATPase activity, rotational mechanism establishment of organelle localization positive regulation of ERK1 and ERK2 cascade hydrogen ion transmembrane transport positive regulation of osteoclast development proton-transporting V-type ATPase complex assembly uc009tol.1 uc009tol.2 uc009tol.3 
ENSMUST00000019266.6 Ccl9 ENSMUST00000019266.6 C-C motif chemokine ligand 9 (from RefSeq NM_011338.2) Ccl9 ENSMUST00000019266.1 ENSMUST00000019266.2 ENSMUST00000019266.3 ENSMUST00000019266.4 ENSMUST00000019266.5 NM_011338 Q3U9T8 Q3U9T8_MOUSE uc007kpj.1 uc007kpj.2 uc007kpj.3 Secreted Belongs to the intercrine beta (chemokine CC) family. cytokine activity extracellular region extracellular space chemotaxis immune response signal transduction chemokine activity cell chemotaxis uc007kpj.1 uc007kpj.2 uc007kpj.3 
ENSMUST00000019268.11 Scrn1 ENSMUST00000019268.11 secernin 1, transcript variant 1 (from RefSeq NM_027268.3) ENSMUST00000019268.1 ENSMUST00000019268.10 ENSMUST00000019268.2 ENSMUST00000019268.3 ENSMUST00000019268.4 ENSMUST00000019268.5 ENSMUST00000019268.6 ENSMUST00000019268.7 ENSMUST00000019268.8 ENSMUST00000019268.9 Kiaa0193 NM_027268 Q3UKR2 Q8CCL3 Q9CZC8 SCRN1_MOUSE uc009bzw.1 uc009bzw.2 uc009bzw.3 Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). Cytoplasm 'Secern' is an archaic English term meaning 'secrete'. Belongs to the peptidase C69 family. Secernin subfamily. Sequence=BAC97894.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component nucleus cytoplasm proteolysis exocytosis dipeptidase activity nuclear membrane uc009bzw.1 uc009bzw.2 uc009bzw.3 
ENSMUST00000019276.12 BC005537 ENSMUST00000019276.12 cDNA sequence BC005537 (from RefSeq NM_024473.3) CF062_MOUSE ENSMUST00000019276.1 ENSMUST00000019276.10 ENSMUST00000019276.11 ENSMUST00000019276.2 ENSMUST00000019276.3 ENSMUST00000019276.4 ENSMUST00000019276.5 ENSMUST00000019276.6 ENSMUST00000019276.7 ENSMUST00000019276.8 ENSMUST00000019276.9 NM_024473 Q99LU8 uc007pwi.1 uc007pwi.2 uc007pwi.3 molecular_function biological_process uc007pwi.1 uc007pwi.2 uc007pwi.3 
ENSMUST00000019290.3 Cacng2 ENSMUST00000019290.3 calcium channel, voltage-dependent, gamma subunit 2 (from RefSeq NM_007583.2) Cacng2 ENSMUST00000019290.1 ENSMUST00000019290.2 NM_007583 Q3ZB20 Q3ZB20_MOUSE uc007wop.1 uc007wop.2 uc007wop.3 uc007wop.4 Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Membrane ulti-pass membrane protein Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity cytosol plasma membrane voltage-gated calcium channel complex protein targeting to membrane ion transport calcium ion transport cell surface postsynaptic density membrane integral component of membrane AMPA glutamate receptor complex regulation of ion transmembrane transport ionotropic glutamate receptor binding cerebellar mossy fiber response to calcium ion eye blink reflex calcium ion transmembrane transport postsynaptic density membrane positive regulation of protein localization to basolateral plasma membrane regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc007wop.1 uc007wop.2 uc007wop.3 uc007wop.4 
ENSMUST00000019291.7 Psg28 ENSMUST00000019291.7 pregnancy-specific beta-1-glycoprotein 28 (from RefSeq NM_054063.4) ENSMUST00000019291.1 ENSMUST00000019291.2 ENSMUST00000019291.3 ENSMUST00000019291.4 ENSMUST00000019291.5 ENSMUST00000019291.6 NM_054063 Psg28 Q4KL66 Q4KL66_MOUSE uc009fjk.1 uc009fjk.2 uc009fjk.3 uc009fjk.4 molecular_function cellular_component female pregnancy biological_process uc009fjk.1 uc009fjk.2 uc009fjk.3 uc009fjk.4 
ENSMUST00000019302.10 Tmem160 ENSMUST00000019302.10 transmembrane protein 160, transcript variant 1 (from RefSeq NM_026938.2) ENSMUST00000019302.1 ENSMUST00000019302.2 ENSMUST00000019302.3 ENSMUST00000019302.4 ENSMUST00000019302.5 ENSMUST00000019302.6 ENSMUST00000019302.7 ENSMUST00000019302.8 ENSMUST00000019302.9 NM_026938 Q3TKH9 Q9D938 TM160_MOUSE Tmem160 uc009fhu.1 uc009fhu.2 Mitochondrion inner membrane ; Multi-pass membrane protein Expressed in peripheral sensory neurons of dorsal root ganglia (DRG). Homozygous knockout mice for Tmem160 are healthy and fertile and display normal motor function regarding coordination and locomotion as well as similar somatosensory thresholds for mechanical (tactile) and heat stimulation as wild-type littermates (PubMed:34936870). Homozygous knockout male mice show a delay establishment of tactile hypersensitivity and alterations in selfgrooming after nerve injury (PubMed:34936870). Conditional knockout mice lacking Tmem160 in sensory neurons of dorsal root ganglia (DRG) are healthy and fertile (PubMed:34936870). Belongs to the TMEM160 family. molecular_function mitochondrion biological_process membrane integral component of membrane uc009fhu.1 uc009fhu.2 
ENSMUST00000019323.11 Mdh2 ENSMUST00000019323.11 malate dehydrogenase 2, NAD (mitochondrial) (from RefSeq NM_008617.2) ENSMUST00000019323.1 ENSMUST00000019323.10 ENSMUST00000019323.2 ENSMUST00000019323.3 ENSMUST00000019323.4 ENSMUST00000019323.5 ENSMUST00000019323.6 ENSMUST00000019323.7 ENSMUST00000019323.8 ENSMUST00000019323.9 MDHM_MOUSE Mor1 NM_008617 P08249 Q0QF44 Q8CF79 Q8R1P0 uc008zyz.1 uc008zyz.2 uc008zyz.3 Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate; Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37; Evidence=; Enzyme activity is enhanced by acetylation. Homodimer. Mitochondrion matrix Acetylation is enhanced after treatment either with trichostin A (TCA) or with nicotinamide (NAM) with the appearance of tri- and tetraacetylations. Glucose also increases acetylation (By similarity). Acetylation of Lys-239 and Lys-314 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the LDH/MDH superfamily. MDH type 1 family. Sequence=BAC24986.1; Type=Frameshift; Evidence=; catalytic activity cytoplasm mitochondrion mitochondrial inner membrane mitochondrial matrix carbohydrate metabolic process tricarboxylic acid cycle oxaloacetate metabolic process malate metabolic process internal protein amino acid acetylation NADH metabolic process aerobic respiration membrane oxidoreductase activity malate dehydrogenase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor carboxylic acid metabolic process L-malate dehydrogenase activity protein homodimerization activity myelin sheath protein self-association malate dehydrogenase (NADP+) activity oxidation-reduction process uc008zyz.1 uc008zyz.2 uc008zyz.3 
ENSMUST00000019333.10 Rnf145 ENSMUST00000019333.10 ring finger protein 145, transcript variant 1 (from RefSeq NM_028862.4) ENSMUST00000019333.1 ENSMUST00000019333.2 ENSMUST00000019333.3 ENSMUST00000019333.4 ENSMUST00000019333.5 ENSMUST00000019333.6 ENSMUST00000019333.7 ENSMUST00000019333.8 ENSMUST00000019333.9 NM_028862 Q5SWK7 Q8BXX5 Q9CXG1 RN145_MOUSE Rnf145 uc007inh.1 uc007inh.2 uc007inh.3 E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'- linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species (PubMed:26194095). Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function (PubMed:29374057). In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately down-regulating cholesterol biosynthesis (PubMed:29068315). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence= Interacts (via YLYF motif) with INSIG1 and INSIG2. Endoplasmic reticulum membrane ulti-pass membrane protein By high-cholesterol diet. Knockout mice generated by CRISPR-Cas9-mediated gene editing are born at the expected Mendelian rate. Compared to wild- type littermates, mutant mice show slightly reduced body weight and increased serum cholesterol levels. endoplasmic reticulum endoplasmic reticulum membrane zinc ion binding endomembrane system membrane integral component of membrane protein ubiquitination transferase activity metal ion binding ubiquitin protein ligase activity uc007inh.1 uc007inh.2 uc007inh.3 
ENSMUST00000019354.11 Atp6v1e1 ENSMUST00000019354.11 ATPase, H+ transporting, lysosomal V1 subunit E1 (from RefSeq NM_007510.3) Atp6e Atp6e2 ENSMUST00000019354.1 ENSMUST00000019354.10 ENSMUST00000019354.2 ENSMUST00000019354.3 ENSMUST00000019354.4 ENSMUST00000019354.5 ENSMUST00000019354.6 ENSMUST00000019354.7 ENSMUST00000019354.8 ENSMUST00000019354.9 NM_007510 P50518 Q3UK59 Q8K5D6 Q99LD0 VATE1_MOUSE uc009dnr.1 uc009dnr.2 uc009dnr.3 Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with RABL2/RABL2A; binds preferentially to GTP- bound RABL2 (PubMed:23055941). Interacts with ALDOC (By similarity). Interacts with RAB11B (By similarity). Apical cell membrane ; Peripheral membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein Expressed within the midpiece of sperm tail (at protein level) (PubMed:11872743, PubMed:23055941). Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level) (PubMed:29993276). Belongs to the V-ATPase E subunit family. protein binding cytoplasm mitochondrion endosome cytosol microvillus ion transport hydrogen-exporting ATPase activity, phosphorylative mechanism apical plasma membrane hydrolase activity proton-transporting two-sector ATPase complex, catalytic domain proton-transporting ATPase activity, rotational mechanism ATPase binding hydrogen ion transmembrane transport uc009dnr.1 uc009dnr.2 uc009dnr.3 
ENSMUST00000019378.8 Mlh3 ENSMUST00000019378.8 mutL homolog 3, transcript variant 1 (from RefSeq NM_175337.2) ENSMUST00000019378.1 ENSMUST00000019378.2 ENSMUST00000019378.3 ENSMUST00000019378.4 ENSMUST00000019378.5 ENSMUST00000019378.6 ENSMUST00000019378.7 Mlh3 NM_175337 Q68FG1 Q68FG1_MOUSE uc007ogt.1 uc007ogt.2 uc007ogt.3 uc007ogt.4 Belongs to the DNA mismatch repair MutL/HexB family. condensed chromosome condensed nuclear chromosome synaptonemal complex male germ cell nucleus chromatin binding ATP binding nucleus nucleoplasm chiasma mismatch repair cellular response to DNA damage stimulus synaptonemal complex assembly male meiosis female meiosis I protein localization ATPase activity centromeric DNA binding mismatched DNA binding mismatch repair complex uc007ogt.1 uc007ogt.2 uc007ogt.3 uc007ogt.4 
ENSMUST00000019382.17 Tecr ENSMUST00000019382.17 trans-2,3-enoyl-CoA reductase, transcript variant 1 (from RefSeq NM_134118.5) ENSMUST00000019382.1 ENSMUST00000019382.10 ENSMUST00000019382.11 ENSMUST00000019382.12 ENSMUST00000019382.13 ENSMUST00000019382.14 ENSMUST00000019382.15 ENSMUST00000019382.16 ENSMUST00000019382.2 ENSMUST00000019382.3 ENSMUST00000019382.4 ENSMUST00000019382.5 ENSMUST00000019382.6 ENSMUST00000019382.7 ENSMUST00000019382.8 ENSMUST00000019382.9 Gpsn2 NM_134118 Q9CY27 TECR_MOUSE uc009mkm.1 uc009mkm.2 uc009mkm.3 uc009mkm.4 Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (By similarity). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (By similarity). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (By similarity). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (By similarity). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (By similarity). Reaction=a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH; Xref=Rhea:RHEA:14473, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:83724, ChEBI:CHEBI:83728; EC=1.3.1.93; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:14475; Evidence=; Reaction=NADP(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H(+) + NADPH; Xref=Rhea:RHEA:35351, ChEBI:CHEBI:15378, ChEBI:CHEBI:57394, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:71412; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:35353; Evidence=; Reaction=(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+); Xref=Rhea:RHEA:39331, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:73856, ChEBI:CHEBI:76416; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39332; Evidence=; Reaction=(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+); Xref=Rhea:RHEA:39467, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:73870, ChEBI:CHEBI:76461; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39468; Evidence=; Reaction=(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+); Xref=Rhea:RHEA:39319, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:74264, ChEBI:CHEBI:76412; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39320; Evidence=; Reaction=(2E)-hexadecenoyl-CoA + H(+) + NADPH = hexadecanoyl-CoA + NADP(+); Xref=Rhea:RHEA:36143, ChEBI:CHEBI:15378, ChEBI:CHEBI:57379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61526; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36144; Evidence=; Lipid metabolism; fatty acid biosynthesis. Lipid metabolism; sphingolipid metabolism. Interacts with ELOVL1 and LASS2. Endoplasmic reticulum membrane ; Multi-pass membrane protein Glycosylated. Belongs to the steroid 5-alpha reductase family. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process sphingolipid metabolic process steroid biosynthetic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors integral component of endoplasmic reticulum membrane fatty acid elongation very long-chain fatty acid biosynthetic process oxidation-reduction process uc009mkm.1 uc009mkm.2 uc009mkm.3 uc009mkm.4 
ENSMUST00000019386.10 Ripk4 ENSMUST00000019386.10 receptor-interacting serine-threonine kinase 4 (from RefSeq NM_023663.7) Ankrd3 ENSMUST00000019386.1 ENSMUST00000019386.2 ENSMUST00000019386.3 ENSMUST00000019386.4 ENSMUST00000019386.5 ENSMUST00000019386.6 ENSMUST00000019386.7 ENSMUST00000019386.8 ENSMUST00000019386.9 NM_023663 Pkk Q3UM04 Q9ERK0 RIPK4_MOUSE uc008adn.1 uc008adn.2 uc008adn.3 Involved in stratified epithelial development (By similarity). It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts with PRKCB. Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Q9ERK0; Q6Q0C0: TRAF7; Xeno; NbExp=2; IntAct=EBI-6116422, EBI-307556; Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state, a minor portion of this protein is membrane- associated. The major portion is cytoplasmic. Ubiquitously expressed, with an abundant expression in the thymus, bone marrow, pro-B, pre-B and immature B cells and a weak expression in the spleen. Expressed at 10.5 dpc at diverse locations including the embryonic forebrain, otic vesicle, branchial arches, primitive gut, and genitourinary system. Transient expression in the ventral neural tube at 12.5 dpc. By 14.5 dpc, strong expression throughout the gastrointestinal tract was observed in the luminal tissues of the esophagus, stomach, duodenum, and intestines, as well as transient expression in the skin. Not expressed in kidney. May be phosphorylated by MAP3K2 and MAP3K3. Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-342 and Asp-380. Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. nucleotide binding morphogenesis of an epithelium protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm protein phosphorylation membrane kinase activity phosphorylation transferase activity positive regulation of NF-kappaB transcription factor activity uc008adn.1 uc008adn.2 uc008adn.3 
ENSMUST00000019405.4 Map1s ENSMUST00000019405.4 microtubule-associated protein 1S (from RefSeq NM_173013.3) Bpy2ip1 E9QKR8 ENSMUST00000019405.1 ENSMUST00000019405.2 ENSMUST00000019405.3 MAP1S_MOUSE Map8 Mtap1s NM_173013 Q3TSD6 Q7TMW8 Q8C052 uc009mcd.1 uc009mcd.2 uc009mcd.3 uc009mcd.4 Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis (By similarity). Involved in the formation of microtubule bundles. Heterodimer of a heavy and a light chain. Interacts with microtubules and actin. Both MAP1S heavy and light chains interact with microtubules. MAP1S light chain interacts with actin. Interacts with ESR1, LRPPRC, RASSF1, microtubules and VCY2. Interacts with WDR47 (via N-terminus of light chain) (By similarity). Interacts (via C-terminus) with GAN (via Kelch domains). Nucleus Cytoplasm, cytosol Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, spindle Note=Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules. Detected in filopodia-like protrusions and synapses (By similarity). Expressed in ventral and dorsal horns of the spinal cord, hippocampus, cerebral cortex, molecular, Purkinje and granular cell layers of the cerebellum and in dorsal root ganglia of the PNS (at protein level). Expressed in brain, testis, heart, lung, kidney and liver. Expressed in embryo at 10 dpc onwards (at protein level). Its C-terminal part of the heavy chain interacts with ESR1 (By similarity). The N-terminus of the heavy chain associates with the C- terminus of the light chain to form the heterodimer complex. Belongs to the MAP1 family. Sequence=AAH52828.1; Type=Erroneous initiation; Evidence=; Sequence=AAH52828.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. At the N-terminus.; Evidence=; microtubule cytoskeleton organization microtubule bundle formation DNA binding actin binding nucleus nucleolus cytoplasm spindle cytosol cytoskeleton microtubule microtubule associated complex apoptotic process nervous system development axonogenesis brain development microtubule binding regulation of chromatin disassembly microtubule cytoskeleton tubulin binding dendrite development cell junction dendrite regulation of microtubule depolymerization identical protein binding cell projection neuronal cell body synapse perinuclear region of cytoplasm beta-tubulin binding neuron projection morphogenesis actin filament binding uc009mcd.1 uc009mcd.2 uc009mcd.3 uc009mcd.4 
ENSMUST00000019422.6 Dpep1 ENSMUST00000019422.6 dipeptidase 1, transcript variant 1 (from RefSeq NM_007876.3) DPEP1_MOUSE ENSMUST00000019422.1 ENSMUST00000019422.2 ENSMUST00000019422.3 ENSMUST00000019422.4 ENSMUST00000019422.5 G5E824 Mbd1 NM_007876 P31428 Rdp uc009nui.1 uc009nui.2 uc009nui.3 uc009nui.4 uc009nui.5 Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:12738806, PubMed:31442408, PubMed:9560193). Hydrolyzes cystinyl-bis-glycine (cys- bis-gly) formed during glutathione degradation (PubMed:12738806, PubMed:9560193). Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (PubMed:12738806). Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver. Reaction=an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid; Xref=Rhea:RHEA:48940, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869, ChEBI:CHEBI:77460; EC=3.4.13.19; Evidence= Reaction=H2O + leukotriene D4 = glycine + leukotriene E4; Xref=Rhea:RHEA:48616, ChEBI:CHEBI:15377, ChEBI:CHEBI:57305, ChEBI:CHEBI:57462, ChEBI:CHEBI:63166; Evidence=; Reaction=2 H2O + L-cystine-bis-glycine = 2 glycine + L-cystine; Xref=Rhea:RHEA:60520, ChEBI:CHEBI:15377, ChEBI:CHEBI:35491, ChEBI:CHEBI:57305, ChEBI:CHEBI:143812; Evidence=; Reaction=a beta-lactam + H2O = a substituted beta-amino acid; Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627, ChEBI:CHEBI:140347; EC=3.5.2.6; Evidence=; Reaction=glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine; Xref=Rhea:RHEA:62704, ChEBI:CHEBI:15377, ChEBI:CHEBI:57305, ChEBI:CHEBI:145925, ChEBI:CHEBI:145926; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Inhibited by L-penicillamine. Inhibited by cilastatin. Kinetic parameters: KM=10 uM for leukotriene D4 ; KM=0.45 mM for cystinyl-bis-glycine ; KM=111 uM for beta-lactam ; Homodimer; disulfide-linked. Apical cell membrane ; Lipid-anchor, GPI-anchor Cell projection, microvillus membrane ; Lipid-anchor, GPI-anchor Note=Brush border membrane. Expressed in heart, lung, skeletal muscle, kidney, liver, and testis. Not detected in brain and spleen. Deficient mice are phenotypically normal. However deficient mice display a partial loss in the conversion of leukotriene D4 to leukotrience E4 and in the conversion of cys-bis-gly to cysteine and glycine (PubMed:9560193). Deficient mice display reduces mortality in models of sepsis (PubMed:31442408). Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. extracellular space nucleus plasma membrane proteolysis apoptotic process peptidase activity metalloexopeptidase activity metallopeptidase activity dipeptidyl-peptidase activity zinc ion binding membrane apical plasma membrane hydrolase activity dipeptidase activity antibiotic metabolic process cell junction negative regulation of cell migration anchored component of membrane microvillus membrane GPI anchor binding cellular response to drug cell projection cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process apical part of cell metal ion binding homocysteine metabolic process metallodipeptidase activity cellular response to calcium ion cellular response to nitric oxide modified amino acid binding uc009nui.1 uc009nui.2 uc009nui.3 uc009nui.4 uc009nui.5 
ENSMUST00000019426.5 Dsg4 ENSMUST00000019426.5 desmoglein 4 (from RefSeq NM_181564.3) DSG4_MOUSE ENSMUST00000019426.1 ENSMUST00000019426.2 ENSMUST00000019426.3 ENSMUST00000019426.4 NM_181564 Q7TMD7 uc008een.1 uc008een.2 This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. This gene is expressed in the suprabasal epidermis and hair follicle. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Certain mutations in this gene are responsible for the lanceolate hair phenotype in mice. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Feb 2016]. ##Evidence-Data-START## Transcript exon combination :: AY191584.1, AY227349.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. Cell membrane ; Single-pass type I membrane protein Cell junction, desmosome Strongly expressed in the skin; during the anagen stage of hair follicles in the matrix, precortex and inner rooth sheath. Expressed in embryo at 7 to 17 dpc. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Note=Defects in Dsg4 are the cause of an autosomal recessive phenotype lanceolate hair (lah). Lah mice pups develop only a few short hairs on the head and neck which form a lance head at the tip and disappear within a few month. They have thickened skin and do not exhibit any growth retardation. hair follicle development calcium ion binding plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane cell junction desmosome keratinocyte differentiation BMP signaling pathway metal ion binding cell-cell adhesion uc008een.1 uc008een.2 
ENSMUST00000019439.9 Tmem129 ENSMUST00000019439.9 transmembrane protein 129, transcript variant 1 (from RefSeq NM_026698.3) ENSMUST00000019439.1 ENSMUST00000019439.2 ENSMUST00000019439.3 ENSMUST00000019439.4 ENSMUST00000019439.5 ENSMUST00000019439.6 ENSMUST00000019439.7 ENSMUST00000019439.8 NM_026698 Q3TA74 Q8K304 Q9DCF3 TM129_MOUSE uc008xay.1 uc008xay.2 uc008xay.3 E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Integral component of ER-resident dislocation complexes. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K304-1; Sequence=Displayed; Name=2; IsoId=Q8K304-2; Sequence=VSP_026159; The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity. Belongs to the TMEM129 family. protein polyubiquitination endoplasmic reticulum endoplasmic reticulum membrane response to unfolded protein membrane integral component of membrane protein ubiquitination transferase activity ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol metal ion binding ubiquitin protein ligase activity uc008xay.1 uc008xay.2 uc008xay.3 
ENSMUST00000019441.9 Nop9 ENSMUST00000019441.9 NOP9 nucleolar protein (from RefSeq NM_026403.3) ENSMUST00000019441.1 ENSMUST00000019441.2 ENSMUST00000019441.3 ENSMUST00000019441.4 ENSMUST00000019441.5 ENSMUST00000019441.6 ENSMUST00000019441.7 ENSMUST00000019441.8 NM_026403 NOP9_MOUSE Q3TW87 Q8BKR9 Q8BMC4 Q8BYV4 Q8VEF9 Q9D0C6 Q9D5A8 uc007uao.1 uc007uao.2 uc007uao.3 uc007uao.4 Belongs to the NOP9 family. Sequence=BAB29900.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC34455.1; Type=Frameshift; Evidence=; Sequence=BAC39042.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; RNA binding cellular_component biological_process uc007uao.1 uc007uao.2 uc007uao.3 uc007uao.4 
ENSMUST00000019443.15 Rnf31 ENSMUST00000019443.15 ring finger protein 31 (from RefSeq NM_194346.3) ENSMUST00000019443.1 ENSMUST00000019443.10 ENSMUST00000019443.11 ENSMUST00000019443.12 ENSMUST00000019443.13 ENSMUST00000019443.14 ENSMUST00000019443.2 ENSMUST00000019443.3 ENSMUST00000019443.4 ENSMUST00000019443.5 ENSMUST00000019443.6 ENSMUST00000019443.7 ENSMUST00000019443.8 ENSMUST00000019443.9 NM_194346 Paul Q924T7 RNF31_MOUSE Rnf31 uc007tzi.1 uc007tzi.2 uc007tzi.3 E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:28701375). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:28701375). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (By similarity). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (By similarity). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (By similarity). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (By similarity). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (By similarity). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR- induced NF-kappa-B activation (By similarity). Binds polyubiquitin of different linkage types (By similarity). Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence=; Protein modification; protein ubiquitination. Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31 (By similarity). LUBAC has a MW of approximately 600 kDa suggesting a heteromultimeric assembly of its subunits (By similarity). Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner (By similarity). Interacts (via the PUB domain) with OTULIN (via the PIM motif); the interaction is direct (PubMed:23708998). Interacts (via the PUB domain) with VCP (via the PIM motif) (By similarity). Interacts (via the PUB domain) with SPATA2 (via the PIM motif); interaction is direct and bridges RNF31 and CYLD (By similarity). Interacts with CYLD; the interaction is indirect and is mediated via SPATA2 (By similarity). Interacts with MUSK (PubMed:14678832). Interacts with CARD11, promoting linear ubiquitination of BCL10 (By similarity). Q924T7; O88522: Ikbkg; NbExp=7; IntAct=EBI-647680, EBI-998011; Q924T7; Q9WUB0: Rbck1; NbExp=10; IntAct=EBI-647680, EBI-6141072; Q924T7; Q91WA6: Sharpin; NbExp=10; IntAct=EBI-647680, EBI-646097; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q924T7-1; Sequence=Displayed; Name=2; IsoId=Q924T7-2; Sequence=VSP_009649; Widely expressed (at protein level). Not expressed in heart. The PUB domain mediates interaction with the PIM motifs of VCP and RNF31, with a strong preference for RNF31. The RanBP2-type zinc fingers mediate the specific interaction with ubiquitin. The UBA domain mediates association with RBCK1/HOIL1 via interaction with its UBL domain. RING 1 and IBR zinc-fingers catalyze the first step transfer of ubiquitin from the E2 onto RING 2, to transiently form a HECT-like covalent thioester intermediate. The linear ubiquitin chain determining domain (LDD) mediates the final transfer of ubiquitin from RING 2 onto the N-terminus of a target ubiquitin. Autoubiquitinated (PubMed:29950720). Interaction with OTULIN is required to suppress formation of 'Met-1'-linked polyubiquitin chains and prevent subsequent inactivation of the LUBAC complex (PubMed:29950720). Cleaved by caspase during apoptosis. Belongs to the RBR family. protein polyubiquitination ubiquitin-protein transferase activity protein binding cytoplasm cytosol cytoplasmic side of plasma membrane protein ubiquitination transferase activity CD40 signaling pathway ubiquitin protein ligase binding CD40 receptor complex positive regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding metal ion binding T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity negative regulation of necroptotic process LUBAC complex protein linear polyubiquitination uc007tzi.1 uc007tzi.2 uc007tzi.3 
ENSMUST00000019445.6 Hsd17b1 ENSMUST00000019445.6 hydroxysteroid (17-beta) dehydrogenase 1 (from RefSeq NM_010475.2) ENSMUST00000019445.1 ENSMUST00000019445.2 ENSMUST00000019445.3 ENSMUST00000019445.4 ENSMUST00000019445.5 Hsd17b1 NM_010475 Q790P4 Q790P4_MOUSE uc007lnb.1 uc007lnb.2 uc007lnb.3 Belongs to the short-chain dehydrogenases/reductases (SDR) family. estradiol 17-beta-dehydrogenase activity cytoplasm cytosol estrogen biosynthetic process oxidoreductase activity testosterone dehydrogenase (NAD+) activity oxidation-reduction process bone development testosterone biosynthetic process cellular response to metal ion uc007lnb.1 uc007lnb.2 uc007lnb.3 
ENSMUST00000019447.15 Psmc3ip ENSMUST00000019447.15 proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein (from RefSeq NM_008949.3) ENSMUST00000019447.1 ENSMUST00000019447.10 ENSMUST00000019447.11 ENSMUST00000019447.12 ENSMUST00000019447.13 ENSMUST00000019447.14 ENSMUST00000019447.2 ENSMUST00000019447.3 ENSMUST00000019447.4 ENSMUST00000019447.5 ENSMUST00000019447.6 ENSMUST00000019447.7 ENSMUST00000019447.8 ENSMUST00000019447.9 HOP2_MOUSE Hop2 NM_008949 O35047 Q3V035 Tbpip uc007lnh.1 uc007lnh.2 uc007lnh.3 uc007lnh.4 Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double- strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Interacts with the DNA-binding domain of the nuclear receptors NR3C1/GR, ESR2/ER-beta, THRB and RXRA (By similarity). Forms a stable heterodimer with MND1. Interacts with PSMC3/TBP1. Nucleus Highly expressed in testis and more specifically in spermatocytes. Detected in spleen, ovary and thymus. Overexpressed at day 11 in the embryo. Phosphorylated by PKA, PKC and MAPK. Infertility. Males exhibit testicular hypoplasia with lack of spermatozoa. Spermatocytes arrest at the stage of pachytene-like chromosome condensation and spermatogenesis is blocked at prophase of meiosis I. Axial elements are fully developed, but synapsis is limited. While meiotic double-stranded breaks are formed and processed, they fail to be repaired. Belongs to the HOP2 family. DNA binding nucleus nucleoplasm DNA recombination reciprocal meiotic recombination estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity glucocorticoid receptor binding protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter thyroid hormone receptor binding androgen receptor binding DBD domain binding meiotic cell cycle uc007lnh.1 uc007lnh.2 uc007lnh.3 uc007lnh.4 
ENSMUST00000019456.5 Grb7 ENSMUST00000019456.5 growth factor receptor bound protein 7 (from RefSeq NM_010346.2) ENSMUST00000019456.1 ENSMUST00000019456.2 ENSMUST00000019456.3 ENSMUST00000019456.4 GRB7_MOUSE NM_010346 Q03160 Q3TH55 uc007lgk.1 uc007lgk.2 Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration (By similarity). Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress. Homodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when phosphorylated), EPHB1, INSR, FGFR1, PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with SHC1. Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1 (By similarity). Interacts (via SH2 domain) with RET and PTK2/FAK1. Interacts (when not phosphorylated) with ELAVL1. In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, PTK2/FAK1, STAU1, ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Q03160; P70372: Elavl1; NbExp=7; IntAct=EBI-7100053, EBI-6877056; Q03160; Q02858: Tek; NbExp=3; IntAct=EBI-7100053, EBI-7099626; Q03160; Q80ZW7: Tia1; NbExp=4; IntAct=EBI-7100053, EBI-7809240; Q03160; Q03135: CAV1; Xeno; NbExp=3; IntAct=EBI-7100053, EBI-603614; Cytoplasm Cell projection Cell junction, focal adhesion Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic granule Note=Predominantly cytoplasmic. Detected in stress granules where mRNA is stored under stress conditions. The PH domain mediates interaction with membranes containing phosphoinositides. Phosphorylated on serine and threonine residues in response to activation of receptor kinases. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down-stream protein kinases (By similarity). Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress. Belongs to the GRB7/10/14 family. RNA binding SH3/SH2 adaptor activity protein binding cytoplasm cytosol plasma membrane focal adhesion signal transduction lipid binding positive regulation of signal transduction cytoplasmic stress granule membrane negative regulation of translation protein kinase binding cell junction positive regulation of cell migration stress granule assembly phosphatidylinositol binding identical protein binding cell projection insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway uc007lgk.1 uc007lgk.2 
ENSMUST00000019464.8 Noxo1 ENSMUST00000019464.8 NADPH oxidase organizer 1, transcript variant 1 (from RefSeq NM_027988.4) ENSMUST00000019464.1 ENSMUST00000019464.2 ENSMUST00000019464.3 ENSMUST00000019464.4 ENSMUST00000019464.5 ENSMUST00000019464.6 ENSMUST00000019464.7 NM_027988 NOXO1_MOUSE Q3TZA4 Q8BH41 Q8VCM2 Q9D747 Snx28 uc008axs.1 uc008axs.2 uc008axs.3 uc008axs.4 uc008axs.5 Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. Interacts with NOX1, NOXA1 and NCF2/p67phox. Interacts with SH3PXD2A and SH3PXD2B (By similarity). Interacts with CYBA/p22phox (PubMed:17140397). Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Associates with the plasma membrane in a lipid-dependent manner. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VCM2-1; Sequence=Displayed; Name=2; IsoId=Q8VCM2-2; Sequence=VSP_017562, VSP_017563; Strongly expressed by colon epithelial cells and to a lower extent in small intestine, uterus, stomach and testis. Expressed in different parts of the inner ear including sensory and nonsensory cell layers of the saccule, ampullae of the semicircular canals, the stria vascularis and the spiral glanglion neurons. Strongly expressed in inner ear during embryogenesis. The PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation. The SH3 domains mediate interaction with CYBA/p22phox. Mice display balance defects being unable to orient themselves with respect to the gravitational force. This is associated with a defect in otoconia biogenesis in the inner ear. plasma membrane superoxide metabolic process lipid binding membrane superoxide-generating NADPH oxidase activator activity enzyme binding extracellular matrix disassembly phosphatidylinositol binding NADPH oxidase complex positive regulation of catalytic activity uc008axs.1 uc008axs.2 uc008axs.3 uc008axs.4 uc008axs.5 
ENSMUST00000019469.3 G6pc1 ENSMUST00000019469.3 glucose-6-phosphatase catalytic subunit 1 (from RefSeq NM_008061.4) ENSMUST00000019469.1 ENSMUST00000019469.2 G6PC1_MOUSE G6pc G6pt NM_008061 P35576 Q91WV3 uc007lor.1 uc007lor.2 uc007lor.3 uc007lor.4 The enzyme encoded by this gene is a multisubunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for glucose-6-phosphate, inorganic phosphate, and glucose. This gene is one of three glucose-6-phosphatase catalytic-subunit-encoding genes in mouse. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013448.1, AK050279.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Reaction=D-glucose 6-phosphate + H2O = D-glucose + phosphate; Xref=Rhea:RHEA:16689, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:61548; EC=3.1.3.9; Evidence=; Carbohydrate biosynthesis; gluconeogenesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Liver and kidney. Deficient mice display hypoglycaemia, growth retardation, hepatomegaly, kidney enlargement, hyperlipidaemia, and hyperuricaemia. Belongs to the glucose-6-phosphatase family. glucose-6-phosphatase activity endoplasmic reticulum endoplasmic reticulum membrane glycogen metabolic process glycogen catabolic process gluconeogenesis triglyceride metabolic process phosphate-containing compound metabolic process steroid metabolic process regulation of gene expression glucose-6-phosphate transport membrane integral component of membrane phosphotransferase activity, alcohol group as acceptor hydrolase activity response to food multicellular organism growth phosphate ion binding glucose homeostasis cholesterol homeostasis intracellular membrane-bounded organelle urate metabolic process phosphorylated carbohydrate dephosphorylation glucose 6-phosphate metabolic process lipid homeostasis uc007lor.1 uc007lor.2 uc007lor.3 uc007lor.4 
ENSMUST00000019470.14 Psme3 ENSMUST00000019470.14 proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) (from RefSeq NM_011192.4) ENSMUST00000019470.1 ENSMUST00000019470.10 ENSMUST00000019470.11 ENSMUST00000019470.12 ENSMUST00000019470.13 ENSMUST00000019470.2 ENSMUST00000019470.3 ENSMUST00000019470.4 ENSMUST00000019470.5 ENSMUST00000019470.6 ENSMUST00000019470.7 ENSMUST00000019470.8 ENSMUST00000019470.9 NM_011192 Psme3 Q4FK54 Q4FK54_MOUSE uc007lon.1 uc007lon.2 uc007lon.3 uc007lon.4 Belongs to the PA28 family. p53 binding nucleoplasm cytosol proteolysis peptidase activity proteasome activator complex positive regulation of endopeptidase activity identical protein binding endopeptidase activator activity regulation of proteasomal protein catabolic process MDM2/MDM4 family protein binding negative regulation of extrinsic apoptotic signaling pathway uc007lon.1 uc007lon.2 uc007lon.3 uc007lon.4 
ENSMUST00000019482.8 Zfp687 ENSMUST00000019482.8 zinc finger protein 687, transcript variant 1 (from RefSeq NM_030074.3) ENSMUST00000019482.1 ENSMUST00000019482.2 ENSMUST00000019482.3 ENSMUST00000019482.4 ENSMUST00000019482.5 ENSMUST00000019482.6 ENSMUST00000019482.7 Kiaa1441 NM_030074 Q6PAP3 Q6ZPQ9 Q9D2D7 ZN687_MOUSE Znf687 uc008qhp.1 uc008qhp.2 May be involved in transcriptional regulation. Interacts with ZMYND8. Cytoplasm Nucleus Note=Predominantly nuclear. Localizes to sites of DNA damage. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D2D7-1; Sequence=Displayed; Name=2; IsoId=Q9D2D7-2; Sequence=VSP_018170, VSP_018173; Name=3; IsoId=Q9D2D7-3; Sequence=VSP_018171, VSP_018172; Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus nucleoplasm cytoplasm cytosol biological_process metal ion binding uc008qhp.1 uc008qhp.2 
ENSMUST00000019503.14 Gdpd2 ENSMUST00000019503.14 glycerophosphodiester phosphodiesterase domain containing 2, transcript variant 1 (from RefSeq NM_023608.4) ENSMUST00000019503.1 ENSMUST00000019503.10 ENSMUST00000019503.11 ENSMUST00000019503.12 ENSMUST00000019503.13 ENSMUST00000019503.2 ENSMUST00000019503.3 ENSMUST00000019503.4 ENSMUST00000019503.5 ENSMUST00000019503.6 ENSMUST00000019503.7 ENSMUST00000019503.8 ENSMUST00000019503.9 GDPD2_MOUSE Gde3 NM_023608 Obdpf Q9ESM6 uc009twi.1 uc009twi.2 uc009twi.3 uc009twi.4 uc009twi.5 This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. Overexpression of this gene is associated with activity-dependent actin cytoskeleton disorganization. The encoded protein may negatively regulate growth rate and induce differentiation of osteoblasts. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4-phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton. Reaction=H2O + sn-glycero-3-phospho-1D-myo-inositol = 1D-myo-inositol 1-phosphate + glycerol + H(+); Xref=Rhea:RHEA:14033, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:58433, ChEBI:CHEBI:58444; EC=3.1.4.43; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Kinetic parameters: KM=97.2 mM for glycerophosphoinositol ; Vmax=1.9 nmol/min/mg enzyme ; Cell membrane ; Multi-pass membrane protein Cytoplasm Cytoplasm, cytoskeleton Note=Colocalizes with the actin cytoskeleton. Detected in spleen, femur and calvaria. Up-regulated during osteoblast differentiation. Detected at low levels in mature osteoblasts. Belongs to the glycerophosphoryl diester phosphodiesterase family. The catalytic domain of Gdpd2 is oriented extracellularly; Glycerophosphoinositol is hydrolyzed in the medium of cells overexpressing Gdpd2, whereas intracellular levels of glycerophosphoinositol is not affected. cytoplasm cytoskeleton actin filament plasma membrane lipid metabolic process phosphoric diester hydrolase activity membrane integral component of membrane hydrolase activity lamellipodium positive regulation of osteoblast differentiation metal ion binding glycerophosphoinositol inositolphosphodiesterase activity actin filament reorganization uc009twi.1 uc009twi.2 uc009twi.3 uc009twi.4 uc009twi.5 
ENSMUST00000019506.9 D8Ertd738e ENSMUST00000019506.9 DNA segment, Chr 8, ERATO Doi 738, expressed (from RefSeq NM_001007571.2) ENSMUST00000019506.1 ENSMUST00000019506.2 ENSMUST00000019506.3 ENSMUST00000019506.4 ENSMUST00000019506.5 ENSMUST00000019506.6 ENSMUST00000019506.7 ENSMUST00000019506.8 L10K_MOUSE NM_001007571 Q8R1F0 uc012ghh.1 uc012ghh.2 uc012ghh.3 May have a potential role in hypercalcemia of malignancy. Belongs to the UPF0390 family. molecular_function nucleus nucleolus biological_process uc012ghh.1 uc012ghh.2 uc012ghh.3 
ENSMUST00000019512.8 Sec14l4 ENSMUST00000019512.8 SEC14-like lipid binding 4 (from RefSeq NM_146013.1) ENSMUST00000019512.1 ENSMUST00000019512.2 ENSMUST00000019512.3 ENSMUST00000019512.4 ENSMUST00000019512.5 ENSMUST00000019512.6 ENSMUST00000019512.7 NM_146013 Q8R0F9 S14L4_MOUSE uc007hue.1 uc007hue.2 uc007hue.3 uc007hue.4 Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids. molecular_function cellular_component lipid binding uc007hue.1 uc007hue.2 uc007hue.3 uc007hue.4 
ENSMUST00000019514.10 Calm3 ENSMUST00000019514.10 calmodulin 3 (from RefSeq NM_007590.3) CALM3_MOUSE Calm3 Cam3 Camc ENSMUST00000019514.1 ENSMUST00000019514.2 ENSMUST00000019514.3 ENSMUST00000019514.4 ENSMUST00000019514.5 ENSMUST00000019514.6 ENSMUST00000019514.7 ENSMUST00000019514.8 ENSMUST00000019514.9 NM_007590 P02593 P0DP28 P62204 P70667 P99014 Q3TEH7 Q3THK5 Q3U6Z5 Q3U7C7 Q498A3 Q61379 Q61380 Q8BNC9 Q91VQ9 Q9D6G4 uc009fin.1 uc009fin.2 uc009fin.3 Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin- dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Interacts with CEP97, CCP110, MYO1C, TTN/titin and SRY. Interacts with MYO10. Interacts with RRAD (By similarity). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2. Interacts with SCN5A (By similarity). Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with RYR1 (PubMed:18650434). Interacts with MYO5A (By similarity). Interacts with IQCF1 (PubMed:25380116). Interacts with SYT7 (PubMed:24569478). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity). Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:18650434). Interacts with PCP4; regulates calmodulin calcium- binding (By similarity). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel (By similarity). Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. Ubiquitination results in a strongly decreased activity. Phosphorylation results in a decreased activity. This protein has four functional calcium-binding sites. Belongs to the calmodulin family. Sequence=BAC39089.2; Type=Erroneous translation; Note=Wrong CDS prediction.; Evidence=; G2/M transition of mitotic cell cycle spindle pole response to amphetamine regulation of heart rate calcium ion binding detection of calcium ion nucleus cytoplasm centrosome spindle cytoskeleton spindle microtubule plasma membrane activation of adenylate cyclase activity voltage-gated potassium channel complex adenylate cyclase binding adenylate cyclase activator activity regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum calcium-mediated signaling protein kinase binding protein domain specific binding sarcomere nitric-oxide synthase regulator activity growth cone synaptic vesicle membrane titin binding type 3 metabotropic glutamate receptor binding mitochondrial membrane N-terminal myristoylation domain binding regulation of cytokinesis positive regulation of phosphoprotein phosphatase activity macromolecular complex calcium channel complex positive regulation of protein dephosphorylation neuron projection myelin sheath phosphatidylinositol 3-kinase binding ion channel binding metal ion binding protein N-terminus binding calcium-dependent protein binding nitric-oxide synthase binding positive regulation of nitric-oxide synthase activity positive regulation of cyclic-nucleotide phosphodiesterase activity response to corticosterone response to calcium ion regulation of cardiac muscle contraction regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity protein phosphatase activator activity positive regulation by host of symbiont cAMP-mediated signal transduction establishment of protein localization to membrane establishment of protein localization to mitochondrial membrane disordered domain specific binding regulation of synaptic vesicle endocytosis regulation of high voltage-gated calcium channel activity catalytic complex regulation of synaptic vesicle exocytosis uc009fin.1 uc009fin.2 uc009fin.3 
ENSMUST00000019517.10 Cops3 ENSMUST00000019517.10 COP9 signalosome subunit 3, transcript variant 7 (from RefSeq NR_184535.2) Cops3 ENSMUST00000019517.1 ENSMUST00000019517.2 ENSMUST00000019517.3 ENSMUST00000019517.4 ENSMUST00000019517.5 ENSMUST00000019517.6 ENSMUST00000019517.7 ENSMUST00000019517.8 ENSMUST00000019517.9 NR_184535 Q3UQL2 Q3UQL2_MOUSE uc007jfa.1 uc007jfa.2 uc007jfa.3 Cytoplasm Nucleus Belongs to the CSN3 family. protein deneddylation nucleus nucleoplasm cytoplasm cytosol COP9 signalosome uc007jfa.1 uc007jfa.2 uc007jfa.3 
ENSMUST00000019572.9 Zfp874b ENSMUST00000019572.9 zinc finger protein 874b (from RefSeq NM_001076791.2) ENSMUST00000019572.1 ENSMUST00000019572.2 ENSMUST00000019572.3 ENSMUST00000019572.4 ENSMUST00000019572.5 ENSMUST00000019572.6 ENSMUST00000019572.7 ENSMUST00000019572.8 NM_001076791 Q7M6X2 Q7M6X2_MOUSE Rslcan16 Zfp874b uc007raw.1 uc007raw.2 uc007raw.3 Nucleus nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007raw.1 uc007raw.2 uc007raw.3 
ENSMUST00000019577.10 Gipc1 ENSMUST00000019577.10 GIPC PDZ domain containing family, member 1 (from RefSeq NM_018771.3) ENSMUST00000019577.1 ENSMUST00000019577.2 ENSMUST00000019577.3 ENSMUST00000019577.4 ENSMUST00000019577.5 ENSMUST00000019577.6 ENSMUST00000019577.7 ENSMUST00000019577.8 ENSMUST00000019577.9 GIPC1_MOUSE Gipc NM_018771 Q9Z0G0 Rgs19ip1 Semcap1 uc009mkr.1 uc009mkr.2 uc009mkr.3 Inhibits endothelial cell migration (in vitro). May be involved in G protein-linked signaling (By similarity). Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6 and PLEKHG5 (By similarity). Interacts with RGS19 C-terminus. Interacts with SDC4/syndecan-4 and SEMA4C/semaphorin-4C. Q9Z0G0; A2ARV4: Lrp2; NbExp=2; IntAct=EBI-300855, EBI-300875; Q9Z0G0; Q64151: Sema4c; NbExp=8; IntAct=EBI-300855, EBI-987075; Q9Z0G0; Q9UM54: MYO6; Xeno; NbExp=4; IntAct=EBI-300855, EBI-350606; Cytoplasm Membrane ; Peripheral membrane protein Widely expressed. Detected already at 4.5 dpc, expression peaks at 11.5-12.5 dpc and gradually declines to its adult levels by 18.5 dpc. Belongs to the GIPC family. actin binding GTPase activator activity receptor binding protein binding cytoplasm cytosol brush border cell cortex protein targeting G-protein coupled receptor signaling pathway chemical synaptic transmission synaptic vesicle vesicle membrane glutamate secretion membrane myosin binding endocytic vesicle PDZ domain binding positive regulation of transforming growth factor beta receptor signaling pathway cytoplasmic vesicle regulation of protein stability negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of cytokinesis protein homodimerization activity dendritic spine dendritic shaft endothelial cell migration positive regulation of GTPase activity positive regulation of melanin biosynthetic process regulation of synaptic plasticity cellular response to interleukin-7 presynapse postsynapse glutamatergic synapse regulation of synaptic vesicle exocytosis uc009mkr.1 uc009mkr.2 uc009mkr.3 
ENSMUST00000019608.7 Ptger1 ENSMUST00000019608.7 prostaglandin E receptor 1 (subtype EP1) (from RefSeq NM_013641.3) ENSMUST00000019608.1 ENSMUST00000019608.2 ENSMUST00000019608.3 ENSMUST00000019608.4 ENSMUST00000019608.5 ENSMUST00000019608.6 NM_013641 P35375 PE2R1_MOUSE Ptgerep1 uc009mkt.1 uc009mkt.2 uc009mkt.3 Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues. Cell membrane; Multi-pass membrane protein. Abundant in kidney and in a lesser amount in lung. Phosphorylated. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity prostaglandin receptor activity prostaglandin E receptor activity plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane D1 dopamine receptor binding response to lipopolysaccharide uc009mkt.1 uc009mkt.2 uc009mkt.3 
ENSMUST00000019611.15 Arhgef25 ENSMUST00000019611.15 Rho guanine nucleotide exchange factor 25, transcript variant 1 (from RefSeq NM_028027.3) Arhgef25 ENSMUST00000019611.1 ENSMUST00000019611.10 ENSMUST00000019611.11 ENSMUST00000019611.12 ENSMUST00000019611.13 ENSMUST00000019611.14 ENSMUST00000019611.2 ENSMUST00000019611.3 ENSMUST00000019611.4 ENSMUST00000019611.5 ENSMUST00000019611.6 ENSMUST00000019611.7 ENSMUST00000019611.8 ENSMUST00000019611.9 G5E825 G5E825_MOUSE NM_028027 uc007hik.1 uc007hik.2 uc007hik.3 uc007hik.4 Rho guanyl-nucleotide exchange factor activity regulation of Rho protein signal transduction uc007hik.1 uc007hik.2 uc007hik.3 uc007hik.4 
ENSMUST00000019614.13 Xab2 ENSMUST00000019614.13 XPA binding protein 2 (from RefSeq NM_026156.2) ENSMUST00000019614.1 ENSMUST00000019614.10 ENSMUST00000019614.11 ENSMUST00000019614.12 ENSMUST00000019614.2 ENSMUST00000019614.3 ENSMUST00000019614.4 ENSMUST00000019614.5 ENSMUST00000019614.6 ENSMUST00000019614.7 ENSMUST00000019614.8 ENSMUST00000019614.9 NM_026156 Q8VDT5 Q9CVD8 Q9DCD2 SYF1_MOUSE Syf1 uc009kry.1 uc009kry.2 uc009kry.3 Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing. Associates with RNA polymerase II, the TCR-specific proteins CKN1/CSA and ERCC6/CSB, and XPA. Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19. Nucleus Note=Detected in the splicing complex carrying pre-mRNA. Complete embryonic lethality before 13.5 dpc. Already at 3.5 dpc, the number of homozygous mutant embryos is lower than expected. Belongs to the crooked-neck family. generation of catalytic spliceosome for first transesterification step mRNA splicing, via spliceosome Prp19 complex blastocyst development molecular_function nucleus spliceosomal complex DNA repair transcription-coupled nucleotide-excision repair transcription, DNA-templated RNA processing mRNA processing cellular response to DNA damage stimulus RNA splicing cerebral cortex development U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome post-mRNA release spliceosomal complex uc009kry.1 uc009kry.2 uc009kry.3 
ENSMUST00000019615.11 Cdc37 ENSMUST00000019615.11 cell division cycle 37, transcript variant 2 (from RefSeq NM_016742.5) CDC37_MOUSE ENSMUST00000019615.1 ENSMUST00000019615.10 ENSMUST00000019615.2 ENSMUST00000019615.3 ENSMUST00000019615.4 ENSMUST00000019615.5 ENSMUST00000019615.6 ENSMUST00000019615.7 ENSMUST00000019615.8 ENSMUST00000019615.9 NM_016742 Q3TGP0 Q61081 uc009okg.1 uc009okg.2 uc009okg.3 Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity (By similarity). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (By similarity). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (By similarity). Forms a complex with Hsp90/HSP90AB1 and CDK6 (By similarity). Interacts with HSP90AA1 (By similarity). Interacts with AR, CDK4, CDK6 and EIF2AK1 (By similarity). Interacts with RB1 (By similarity). Interacts with KSR1 (PubMed:10409742). Interacts with FLCN, FNIP1 and FNIP2 (By similarity). Cytoplasm Constitutively sumoylated by UBE2I. Belongs to the CDC37 family. protein binding cytoplasm cytosol protein folding protein C-terminus binding posttranscriptional regulation of gene expression kinase binding protein kinase binding heat shock protein binding mitogen-activated protein kinase kinase kinase binding ruffle membrane macromolecular complex protein kinase B binding regulation of protein kinase activity protein stabilization unfolded protein binding chaperone binding Hsp90 protein binding regulation of interferon-gamma-mediated signaling pathway regulation of type I interferon-mediated signaling pathway scaffold protein binding mitophagy in response to mitochondrial depolarization HSP90-CDC37 chaperone complex protein kinase regulator activity uc009okg.1 uc009okg.2 uc009okg.3 
ENSMUST00000019616.6 Icam5 ENSMUST00000019616.6 intercellular adhesion molecule 5, telencephalin, transcript variant 1 (from RefSeq NM_008319.3) ENSMUST00000019616.1 ENSMUST00000019616.2 ENSMUST00000019616.3 ENSMUST00000019616.4 ENSMUST00000019616.5 G5E826 ICAM5_MOUSE Icam3 NM_008319 Q2KHL7 Q3UY19 Q60625 Tlcn uc009oka.1 uc009oka.2 uc009oka.3 uc009oka.4 ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). Membrane ; Single- pass type I membrane protein Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon. Glycosylation at Asn-54 is critical for functional folding. Belongs to the immunoglobulin superfamily. ICAM family. integrin binding protein binding plasma membrane integral component of plasma membrane phagocytosis cell adhesion membrane integral component of membrane cell-cell adhesion uc009oka.1 uc009oka.2 uc009oka.3 uc009oka.4 
ENSMUST00000019625.12 Myh8 ENSMUST00000019625.12 myosin, heavy polypeptide 8, skeletal muscle, perinatal (from RefSeq NM_177369.3) ENSMUST00000019625.1 ENSMUST00000019625.10 ENSMUST00000019625.11 ENSMUST00000019625.2 ENSMUST00000019625.3 ENSMUST00000019625.4 ENSMUST00000019625.5 ENSMUST00000019625.6 ENSMUST00000019625.7 ENSMUST00000019625.8 ENSMUST00000019625.9 MYH8_MOUSE Myhsp NM_177369 P13542 Q5SX36 uc007jmn.1 uc007jmn.2 uc007jmn.3 This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. This gene is located in a cluster of related genes on chromosome 11. [provided by RefSeq, Jun 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC150737.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Muscle contraction. Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. microfilament motor activity nucleotide binding skeletal muscle contraction motor activity actin binding protein binding ATP binding cytoplasm myosin complex ATPase activity myofibril muscle filament sliding myosin filament ATP metabolic process actin filament binding uc007jmn.1 uc007jmn.2 uc007jmn.3 
ENSMUST00000019633.8 Cd70 ENSMUST00000019633.8 CD70 antigen (from RefSeq NM_011617.2) Cd70 ENSMUST00000019633.1 ENSMUST00000019633.2 ENSMUST00000019633.3 ENSMUST00000019633.4 ENSMUST00000019633.5 ENSMUST00000019633.6 ENSMUST00000019633.7 NM_011617 Q05A52 Q05A52_MOUSE Tnlg8a uc008dee.1 uc008dee.2 Belongs to the tumor necrosis factor family. tumor necrosis factor receptor binding immune response membrane integral component of membrane tumor necrosis factor-mediated signaling pathway uc008dee.1 uc008dee.2 
ENSMUST00000019649.4 Ubb ENSMUST00000019649.4 ubiquitin B, transcript variant 1 (from RefSeq NM_011664.5) ENSMUST00000019649.1 ENSMUST00000019649.2 ENSMUST00000019649.3 NM_011664 Q78XY9 Q78XY9_MOUSE Ubb uc007jjg.1 uc007jjg.2 uc007jjg.3 This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of four direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Pseudogenes of this gene are located on chromosomes 3 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Cytoplasm Nucleus mitochondrion positive regulation of protein ubiquitination neuron projection neuronal cell body mitochondrion transport along microtubule neuron projection morphogenesis regulation of mitochondrial membrane potential regulation of proteasomal protein catabolic process regulation of neuron death positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of protein monoubiquitination uc007jjg.1 uc007jjg.2 uc007jjg.3 
ENSMUST00000019660.11 Zkscan1 ENSMUST00000019660.11 zinc finger with KRAB and SCAN domains 1, transcript variant 1 (from RefSeq NM_133906.4) ENSMUST00000019660.1 ENSMUST00000019660.10 ENSMUST00000019660.2 ENSMUST00000019660.3 ENSMUST00000019660.4 ENSMUST00000019660.5 ENSMUST00000019660.6 ENSMUST00000019660.7 ENSMUST00000019660.8 ENSMUST00000019660.9 NM_133906 Q7TS88 Q8BGS3 Q8BJ55 Q9CRN6 ZKSC1_MOUSE uc009aej.1 uc009aej.2 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGS3-1; Sequence=Displayed; Name=2; IsoId=Q8BGS3-2; Sequence=VSP_016958; Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC27539.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009aej.1 uc009aej.2 
ENSMUST00000019662.11 Ap4m1 ENSMUST00000019662.11 adaptor-related protein complex AP-4, mu 1 (from RefSeq NM_021392.4) AP4M1_MOUSE Ap4m1 ENSMUST00000019662.1 ENSMUST00000019662.10 ENSMUST00000019662.2 ENSMUST00000019662.3 ENSMUST00000019662.4 ENSMUST00000019662.5 ENSMUST00000019662.6 ENSMUST00000019662.7 ENSMUST00000019662.8 ENSMUST00000019662.9 NM_021392 Q9JKC7 uc009aev.1 uc009aev.2 uc009aev.3 uc009aev.4 uc009aev.5 Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (By similarity). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (PubMed:18341993). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity). Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1). Interacts with tyrosine-based sorting signals on the cytoplasmic tail of cargo proteins such as APP, ATG9A, LAMP2 and NAGPA. Interacts with the C-terminal domain of GRID2 (By similarity). Interacts with GRIA1 and GRIA2; the interaction is indirect via CACNG3 (PubMed:18341993). Interacts with CACNG3; CACNG3 associates GRIA1 and GRIA2 with the adaptor protein complex 4 (AP-4) to target them to the somatodendritic compartment of neurons (PubMed:18341993). Interacts with HOOK1 and HOOK2; the interactions are direct, mediate the interaction between FTS-Hook-FHIP (FHF) complex and AP-4 and the perinuclear distribution of AP-4 (By similarity). Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Early endosome Note=Found in soma and dendritic shafts of neuronal cells. Belongs to the adaptor complexes medium subunit family. protein binding endosome early endosome Golgi apparatus trans-Golgi network cytosol protein targeting protein targeting to lysosome intracellular protein transport Golgi to endosome transport protein localization protein transport membrane vesicle-mediated transport protein domain specific binding AP-4 adaptor complex clathrin adaptor complex Golgi to lysosome transport protein localization to basolateral plasma membrane uc009aev.1 uc009aev.2 uc009aev.3 uc009aev.4 uc009aev.5 
ENSMUST00000019677.12 Mknk1 ENSMUST00000019677.12 MAP kinase-interacting serine/threonine kinase 1, transcript variant 3 (from RefSeq NM_021461.5) A2A8W8 A2A8W8_MOUSE ENSMUST00000019677.1 ENSMUST00000019677.10 ENSMUST00000019677.11 ENSMUST00000019677.2 ENSMUST00000019677.3 ENSMUST00000019677.4 ENSMUST00000019677.5 ENSMUST00000019677.6 ENSMUST00000019677.7 ENSMUST00000019677.8 ENSMUST00000019677.9 Mknk1 NM_021461 uc008ufl.1 uc008ufl.2 uc008ufl.3 uc008ufl.4 This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiation factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine- containing mRNA cap. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation kinase activity phosphorylation uc008ufl.1 uc008ufl.2 uc008ufl.3 uc008ufl.4 
ENSMUST00000019679.12 Armc6 ENSMUST00000019679.12 armadillo repeat containing 6 (from RefSeq NM_133972.2) ARMC6_MOUSE ENSMUST00000019679.1 ENSMUST00000019679.10 ENSMUST00000019679.11 ENSMUST00000019679.2 ENSMUST00000019679.3 ENSMUST00000019679.4 ENSMUST00000019679.5 ENSMUST00000019679.6 ENSMUST00000019679.7 ENSMUST00000019679.8 ENSMUST00000019679.9 NM_133972 Q8BNU0 Q8C4P5 Q8C7S1 Q8K2S7 Q99JQ2 Q9CWE4 uc009lzi.1 uc009lzi.2 uc009lzi.3 uc009lzi.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BNU0-1; Sequence=Displayed; Name=2; IsoId=Q8BNU0-2; Sequence=VSP_019462, VSP_019463; Methylated at His-238 by METTL9. Belongs to the ARMC6 family. Sequence=BAC38256.1; Type=Frameshift; Evidence=; hematopoietic progenitor cell differentiation molecular_function cytosol uc009lzi.1 uc009lzi.2 uc009lzi.3 uc009lzi.4 
ENSMUST00000019697.9 Haus5 ENSMUST00000019697.9 HAUS augmin-like complex, subunit 5 (from RefSeq NM_027999.1) ENSMUST00000019697.1 ENSMUST00000019697.2 ENSMUST00000019697.3 ENSMUST00000019697.4 ENSMUST00000019697.5 ENSMUST00000019697.6 ENSMUST00000019697.7 ENSMUST00000019697.8 HAUS5_MOUSE Kiaa0841 NM_027999 Q08EB3 Q0VF86 Q5HZI7 Q6ZQ35 Q8CIK2 Q9D786 uc009gfs.1 uc009gfs.2 uc009gfs.3 uc009gfs.4 Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly (By similarity). Interacts with EML3 (phosphorylated at 'Thr-882') (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D786-1; Sequence=Displayed; Name=2; IsoId=Q9D786-2; Sequence=VSP_013929, VSP_013930; Belongs to the HAUS5 family. Sequence=AAH23723.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH89002.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cytoplasm centrosome microtubule organizing center spindle cytoskeleton microtubule cell cycle centrosome cycle spindle assembly cell division HAUS complex uc009gfs.1 uc009gfs.2 uc009gfs.3 uc009gfs.4 
ENSMUST00000019701.9 Dusp9 ENSMUST00000019701.9 dual specificity phosphatase 9 (from RefSeq NM_029352.3) Dusp9 ENSMUST00000019701.1 ENSMUST00000019701.2 ENSMUST00000019701.3 ENSMUST00000019701.4 ENSMUST00000019701.5 ENSMUST00000019701.6 ENSMUST00000019701.7 ENSMUST00000019701.8 NM_029352 Q7TNL7 Q7TNL7_MOUSE uc009tmb.1 uc009tmb.2 uc009tmb.3 Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. inactivation of MAPK activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytoplasm cytosol protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity kinase activity phosphorylation dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity peptidyl-tyrosine dephosphorylation uc009tmb.1 uc009tmb.2 uc009tmb.3 
ENSMUST00000019708.12 Arid3a ENSMUST00000019708.12 AT-rich interaction domain 3A, transcript variant 1 (from RefSeq NM_007880.4) ARI3A_MOUSE Dri1 Dril1 ENSMUST00000019708.1 ENSMUST00000019708.10 ENSMUST00000019708.11 ENSMUST00000019708.2 ENSMUST00000019708.3 ENSMUST00000019708.4 ENSMUST00000019708.5 ENSMUST00000019708.6 ENSMUST00000019708.7 ENSMUST00000019708.8 ENSMUST00000019708.9 NM_007880 Q3U338 Q62431 Q80YP8 uc007gap.1 uc007gap.2 uc007gap.3 Transcription factor involved in B-cell differentiation. Binds a VH promoter proximal site necessary for induced mu-heavy-chain transcription. Binds the minor groove of a restricted ATC sequence that is sufficient for nuclear matrix association. This sequence motif is present in matrix-associating regions (MARS) proximal to the promoter and flanking E mu. Activates E mu-driven transcription by binding these sites. May be involved in the control of cell cycle progression by the RB1/E2F1 pathway. Homodimer. Heterodimer with ARID3B. Interacts with E2F1 (By similarity). Interacts with GTF2I and BTK. Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm. B-cell specific in the adult. Expressed in B-cell progenitors, down-regulated in the immature B-cell stage, and is up- regulated again at later stages of B-lymphocyte differentiation. Expressed in lymphocytes from fetal liver. Expressed in fetal thymus and brain. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated protein homodimerization activity intracellular membrane-bounded organelle membrane raft positive regulation of transcription from RNA polymerase II promoter uc007gap.1 uc007gap.2 uc007gap.3 
ENSMUST00000019721.7 Pdk4 ENSMUST00000019721.7 pyruvate dehydrogenase kinase, isoenzyme 4 (from RefSeq NM_013743.2) ENSMUST00000019721.1 ENSMUST00000019721.2 ENSMUST00000019721.3 ENSMUST00000019721.4 ENSMUST00000019721.5 ENSMUST00000019721.6 NM_013743 Pdk4 Q544J2 Q544J2_MOUSE uc009awk.1 uc009awk.2 uc009awk.3 Reaction=ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]; Xref=Rhea:RHEA:23052, Rhea:RHEA-COMP:13689, Rhea:RHEA-COMP:13690, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.2; Evidence=; Homodimer. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). Mitochondrion matrix Belongs to the PDK/BCKDK protein kinase family. nucleotide binding protein kinase activity ATP binding mitochondrion mitochondrial matrix protein phosphorylation insulin receptor signaling pathway cellular response to starvation regulation of acetyl-CoA biosynthetic process from pyruvate regulation of glucose metabolic process kinase activity phosphorylation transferase activity regulation of fatty acid biosynthetic process cellular response to fatty acid reactive oxygen species metabolic process negative regulation of anoikis uc009awk.1 uc009awk.2 uc009awk.3 
ENSMUST00000019722.12 Ubxn6 ENSMUST00000019722.12 UBX domain protein 6, transcript variant 1 (from RefSeq NM_024432.3) B8JJA5 ENSMUST00000019722.1 ENSMUST00000019722.10 ENSMUST00000019722.11 ENSMUST00000019722.2 ENSMUST00000019722.3 ENSMUST00000019722.4 ENSMUST00000019722.5 ENSMUST00000019722.6 ENSMUST00000019722.7 ENSMUST00000019722.8 ENSMUST00000019722.9 NM_024432 Q3TTP1 Q3UG19 Q8C4D6 Q91W79 Q99PL6 Q9D7L9 UBXN6_MOUSE Ubxd1 Ubxdc2 Ubxn6 uc008dat.1 uc008dat.2 uc008dat.3 uc008dat.4 May negatively regulate the ATPase activity of VCP, an ATP- driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Interacts with VCP through the PUB domain (via C-terminus) and VIM motif (via N-terminus); the interaction is direct. Forms a ternary complex with CAV1 and VCP. Interacts with SYVN1. Interacts with HERPUD1. Interacts with VCPKMT. May interact with DERL1. Interacts with PLAA, VCP and YOD1; may form a complex involved in macroautophagy. Interacts with LMAN1. Cytoplasm Cytoplasm, cytosol Membrane ; Peripheral membrane protein Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Early endosome membrane ; Peripheral membrane protein Late endosome membrane ; Peripheral membrane protein Lysosome membrane ; Peripheral membrane protein Note=Localizes at the centrosome both in interphase and during mitosis. May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP. Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99PL6-1; Sequence=Displayed; Name=2; IsoId=Q99PL6-2; Sequence=VSP_007454; Widely expressed (at protein level). Highest expression in brain (at protein level). The UBX domain lacks key residues critical for VCP binding. Sequence=BAB26082.1; Type=Frameshift; Evidence=; Sequence=BAC38512.1; Type=Frameshift; Evidence=; Sequence=BAE36284.1; Type=Frameshift; Evidence=; nucleus cytoplasm lysosome lysosomal membrane endosome microtubule organizing center cytosol cytoskeleton membrane macroautophagy extrinsic component of membrane early endosome membrane late endosome membrane endosome to lysosome transport via multivesicular body sorting pathway macromolecular complex ERAD pathway uc008dat.1 uc008dat.2 uc008dat.3 uc008dat.4 
ENSMUST00000019723.8 Mydgf ENSMUST00000019723.8 myeloid derived growth factor (from RefSeq NM_080837.2) A2RSI7 D17Wsu104e ENSMUST00000019723.1 ENSMUST00000019723.2 ENSMUST00000019723.3 ENSMUST00000019723.4 ENSMUST00000019723.5 ENSMUST00000019723.6 ENSMUST00000019723.7 MYDGF_MOUSE Mydgf NM_080837 Q3UG74 Q9CPT4 uc008dbg.1 uc008dbg.2 uc008dbg.3 The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was identified in error as interleukin 25. This activity has not been reproducible, however, and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AK148083.1, SRR1660811.391021.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway. Secreted doplasmic reticulum-Golgi intermediate compartment Endoplasmic reticulum Golgi apparatus Note=The C-terminal RTEL motif may provide retention in the endoplasmic reticulum. Expressed in prostate, spleen and lung, and weakly expressed in the left ventricle (LF) and liver. Expressed predominantly in inflammatory cells, such as monocytes and macrophages, and weakly expressed in neutrophils, T-cells, B-cells, endothelial cells and cardiac myocytes, after myocardial infarction (MI) (at protein level). Up-regulated by ischemia/hypoxia and reperfusion (IR) injury in the left ventricle (at protein level) (PubMed:25581518). Up- regulated during adipocyte differentiation (at protein level) (PubMed:15378209). Mice show normal postnatal body mass gain, develop normally and are fertile. Show larger infarct collagen-rich scars and more severe heart contractile dysfunction compared to wild- type mice after ischemia and reperfusion (IR) injury. Belongs to the MYDGF family. Was originally thought to signal lymphoid cells to proliferate via thymic shared antigen 1 (PubMed:11714798). This work was later retracted (PubMed:12538725). It has been reported that MYDGF is secreted into blood plasma (PubMed:15378209, PubMed:25581518). However, another report studying human MYDGF shows resident localization to the endoplasmic reticulum and Golgi apparatus and secretion when the two most C-terminal residues of the RTEL motif are abolished (By similarity). Sequence=BAB25931.2; Type=Erroneous initiation; Evidence=; angiogenesis positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation extracellular region extracellular space endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus apoptotic process positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of apoptotic process positive regulation of MAPK cascade positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter positive regulation of protein kinase B signaling uc008dbg.1 uc008dbg.2 uc008dbg.3 
ENSMUST00000019726.8 Plin3 ENSMUST00000019726.8 perilipin 3 (from RefSeq NM_025836.3) ENSMUST00000019726.1 ENSMUST00000019726.2 ENSMUST00000019726.3 ENSMUST00000019726.4 ENSMUST00000019726.5 ENSMUST00000019726.6 ENSMUST00000019726.7 M6prbp1 NM_025836 PLIN3_MOUSE Q3TK05 Q8BKV9 Q9CZK1 Q9DBG5 Tip47 uc008dbn.1 uc008dbn.2 uc008dbn.3 Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network. Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain). Q9DBG5; P63017: Hspa8; NbExp=2; IntAct=EBI-643495, EBI-433443; Lipid droplet Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm Note=Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails. Phosphorylation at Tyr-255 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis. Belongs to the perilipin family. Sequence=BAC33798.1; Type=Frameshift; Evidence=; protein binding cytoplasm endosome lipid particle cytosol endosome membrane membrane uc008dbn.1 uc008dbn.2 uc008dbn.3 
ENSMUST00000019734.11 Cyb561 ENSMUST00000019734.11 cytochrome b-561, transcript variant 2 (from RefSeq NM_007805.5) CY561_MOUSE Cyb561 ENSMUST00000019734.1 ENSMUST00000019734.10 ENSMUST00000019734.2 ENSMUST00000019734.3 ENSMUST00000019734.4 ENSMUST00000019734.5 ENSMUST00000019734.6 ENSMUST00000019734.7 ENSMUST00000019734.8 ENSMUST00000019734.9 Mcyt NM_007805 Q3TEC6 Q60720 Q9D6C9 uc007lxr.1 uc007lxr.2 uc007lxr.3 Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles (Probable). It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes (By similarity). Reaction=L-ascorbate(in) + monodehydro-L-ascorbate radical(out) = L- ascorbate(out) + monodehydro-L-ascorbate radical(in); Xref=Rhea:RHEA:66524, ChEBI:CHEBI:38290, ChEBI:CHEBI:59513; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66525; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 2 heme b groups non-covalently. ; Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane ; Multi-pass membrane protein Note=Secretory vesicle containing catecholamines and amidated peptides. Abundantly distributed in a number of neuroendocrine tissues. Mice lacking Cyb561 have significantly decreased amounts of norepinephrine and normetanephrine in the adrenal gland and brain while the biosynthesis of dopamine, the norepinephrine precursor, is normal pointing to a defect in the catecholamine biosynthesis downstream of dopamine probably at the level of the dopamine beta synthase. ferric-chelate reductase activity lysosomal membrane membrane integral component of membrane oxidoreductase activity electron transport chain transport vesicle membrane cytoplasmic vesicle metal ion binding oxidation-reduction process uc007lxr.1 uc007lxr.2 uc007lxr.3 
ENSMUST00000019803.9 Ccdc12 ENSMUST00000019803.9 coiled-coil domain containing 12 (from RefSeq NM_028312.3) CCD12_MOUSE ENSMUST00000019803.1 ENSMUST00000019803.2 ENSMUST00000019803.3 ENSMUST00000019803.4 ENSMUST00000019803.5 ENSMUST00000019803.6 ENSMUST00000019803.7 ENSMUST00000019803.8 NM_028312 Q8R344 Q9CZH5 uc009rum.1 uc009rum.2 uc009rum.3 uc009rum.4 molecular_function U2-type spliceosomal complex biological_process post-mRNA release spliceosomal complex uc009rum.1 uc009rum.2 uc009rum.3 uc009rum.4 
ENSMUST00000019808.12 Plin5 ENSMUST00000019808.12 perilipin 5, transcript variant 1 (from RefSeq NM_025874.3) ENSMUST00000019808.1 ENSMUST00000019808.10 ENSMUST00000019808.11 ENSMUST00000019808.2 ENSMUST00000019808.3 ENSMUST00000019808.4 ENSMUST00000019808.5 ENSMUST00000019808.6 ENSMUST00000019808.7 ENSMUST00000019808.8 ENSMUST00000019808.9 Lsdp5 Mldp NM_025874 Oxpat PLIN5_MOUSE Pat1 Q78IK8 Q8BVZ1 uc008dba.1 uc008dba.2 uc008dba.3 Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE. Homooligomer. Interacts with PNPLA2; prevents interaction of PNPLA2 with ABHD5. Interacts with ABHD5; targets ABHD5 to lipid droplets and promotes interaction of ABHD5 with PNPLA2. Interacts with LIPE. Lipid droplet toplasm Mitochondrion Note=Lipid droplet surface-associated (PubMed:17234449, PubMed:17130488, PubMed:16571721). Exchanges between lipid droplets and the cytoplasm (PubMed:19717842). Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=Q8BVZ1-1; Sequence=Displayed; Name=2; IsoId=Q8BVZ1-2; Sequence=VSP_034085; Highly expressed in oxidative tissues, including heart, liver, brown adipose tissue (BAT) and slow-twitch fibers of skeletal muscle. Lower expression in epididymal white adipose tissue and anterior tibialis and quadriceps. Expressed in adrenal glands. Isoform 2 has the highest expression in heart. Up-regulated by fasting, PPARD, PPARA and PLIN4. Increased in muscle of high-fat diet fed mice. Induced by unsaturated long chain fatty acid in muscle. Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or with lipolytic stimulation. No visible phenotype. Mice lack detectable lipid droplets in heart. The triacylglycerol and fatty acid content in heart is lower. Belongs to the perilipin family. protein binding cytoplasm mitochondrion lipid particle cytosol lipid metabolic process positive regulation of triglyceride biosynthetic process positive regulation of lipid storage positive regulation of sequestering of triglyceride negative regulation of triglyceride catabolic process lipid storage negative regulation of fatty acid beta-oxidation positive regulation of fatty acid beta-oxidation lipid particle organization negative regulation of peroxisome proliferator activated receptor signaling pathway lipase binding identical protein binding negative regulation of lipid catabolic process mitochondrion localization negative regulation of lipase activity positive regulation of lipase activity negative regulation of reactive oxygen species metabolic process uc008dba.1 uc008dba.2 uc008dba.3 
ENSMUST00000019833.5 Fmc1 ENSMUST00000019833.5 formation of mitochondrial complex V assembly factor 1 (from RefSeq NM_025363.3) ENSMUST00000019833.1 ENSMUST00000019833.2 ENSMUST00000019833.3 ENSMUST00000019833.4 FMC1_MOUSE NM_025363 Q9CR13 uc009bki.1 uc009bki.2 uc009bki.3 Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V). Interacts with ATPAF2. Mitochondrion Belongs to the FMC1 family. molecular_function mitochondrion mitochondrial proton-transporting ATP synthase complex assembly negative regulation of lipid catabolic process regulation of type B pancreatic cell proliferation uc009bki.1 uc009bki.2 uc009bki.3 
ENSMUST00000019854.13 Mrpl24 ENSMUST00000019854.13 mitochondrial ribosomal protein L24 (from RefSeq NM_026591.3) ENSMUST00000019854.1 ENSMUST00000019854.10 ENSMUST00000019854.11 ENSMUST00000019854.12 ENSMUST00000019854.2 ENSMUST00000019854.3 ENSMUST00000019854.4 ENSMUST00000019854.5 ENSMUST00000019854.6 ENSMUST00000019854.7 ENSMUST00000019854.8 ENSMUST00000019854.9 NM_026591 Q9CQ06 Q9CX51 Q9D1L7 Q9D7R6 RM24_MOUSE uc008pte.1 uc008pte.2 uc008pte.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uL24 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation uc008pte.1 uc008pte.2 uc008pte.3 
ENSMUST00000019859.9 Gle1 ENSMUST00000019859.9 GLE1 RNA export mediator (from RefSeq NM_028923.3) A3KGV8 ENSMUST00000019859.1 ENSMUST00000019859.2 ENSMUST00000019859.3 ENSMUST00000019859.4 ENSMUST00000019859.5 ENSMUST00000019859.6 ENSMUST00000019859.7 ENSMUST00000019859.8 GLE1_MOUSE Gle1l NM_028923 Q3TT10 Q3TU23 Q3UD65 Q8BT16 Q8R322 Q9D4A6 uc008jaq.1 uc008jaq.2 uc008jaq.3 uc008jaq.4 Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). Associated with the NPC, however it may not be a stable component of the NPC complex since it shuttles between the nucleus and the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and NUPL2 (By similarity). Nucleus Cytoplasm Nucleus, nuclear pore complex Note=Shuttles between the nucleus and the cytoplasm. Shuttling is essential for its mRNA export function. Belongs to the GLE1 family. Sequence=BAC25796.1; Type=Frameshift; Evidence=; Sequence=BAE36515.1; Type=Frameshift; Evidence=; inositol hexakisphosphate binding phospholipid binding nucleus nuclear pore nucleolus cytoplasm cytosol mRNA export from nucleus regulation of translational initiation regulation of translational termination protein transport poly(A)+ mRNA export from nucleus translation initiation factor binding nuclear membrane identical protein binding nuclear pore cytoplasmic filaments mRNA transport uc008jaq.1 uc008jaq.2 uc008jaq.3 uc008jaq.4 
ENSMUST00000019862.3 L3hypdh ENSMUST00000019862.3 L-3-hydroxyproline dehydratase (trans-) (from RefSeq NM_026038.2) B8JJ82 ENSMUST00000019862.1 ENSMUST00000019862.2 NM_026038 Q99KB5 Q9CXA2 T3HPD_MOUSE uc007nvd.1 uc007nvd.2 uc007nvd.3 Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). Reaction=trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O; Xref=Rhea:RHEA:10320, ChEBI:CHEBI:15377, ChEBI:CHEBI:39785, ChEBI:CHEBI:57938; EC=4.2.1.77; Evidence=; Homodimer. In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 273 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity. Belongs to the proline racemase family. cellular_component lyase activity hydro-lyase activity trans-L-3-hydroxyproline dehydratase activity proline racemase activity uc007nvd.1 uc007nvd.2 uc007nvd.3 
ENSMUST00000019876.12 Calr3 ENSMUST00000019876.12 calreticulin 3, transcript variant 1 (from RefSeq NM_028500.3) CALR3_MOUSE Crt2 ENSMUST00000019876.1 ENSMUST00000019876.10 ENSMUST00000019876.11 ENSMUST00000019876.2 ENSMUST00000019876.3 ENSMUST00000019876.4 ENSMUST00000019876.5 ENSMUST00000019876.6 ENSMUST00000019876.7 ENSMUST00000019876.8 ENSMUST00000019876.9 G5E827 NM_028500 Q9D9Q6 uc009mfx.1 uc009mfx.2 uc009mfx.3 CALR3 capacity for calcium-binding may be absent or much lower than that of CALR (By similarity). During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Endoplasmic reticulum lumen Testis specific, absent in mature sperm. Defective sperm migration from the uterus into the oviduct and defective binding to the zona pellucida. Belongs to the calreticulin family. calcium ion binding protein binding nuclear envelope endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane protein folding spermatogenesis cell differentiation endoplasmic reticulum unfolded protein response protein binding involved in protein folding unfolded protein binding uc009mfx.1 uc009mfx.2 uc009mfx.3 
ENSMUST00000019878.8 Leng1 ENSMUST00000019878.8 leukocyte receptor cluster (LRC) member 1 (from RefSeq NM_027203.3) ENSMUST00000019878.1 ENSMUST00000019878.2 ENSMUST00000019878.3 ENSMUST00000019878.4 ENSMUST00000019878.5 ENSMUST00000019878.6 ENSMUST00000019878.7 LENG1_MOUSE NM_027203 Q9DB98 uc009evm.1 uc009evm.2 uc009evm.3 molecular_function cellular_component biological_process uc009evm.1 uc009evm.2 uc009evm.3 
ENSMUST00000019882.16 Polr2i ENSMUST00000019882.16 polymerase (RNA) II (DNA directed) polypeptide I (from RefSeq NM_027259.1) ENSMUST00000019882.1 ENSMUST00000019882.10 ENSMUST00000019882.11 ENSMUST00000019882.12 ENSMUST00000019882.13 ENSMUST00000019882.14 ENSMUST00000019882.15 ENSMUST00000019882.2 ENSMUST00000019882.3 ENSMUST00000019882.4 ENSMUST00000019882.5 ENSMUST00000019882.6 ENSMUST00000019882.7 ENSMUST00000019882.8 ENSMUST00000019882.9 NM_027259 P60898 RPB9_MOUSE uc009gdt.1 uc009gdt.2 uc009gdt.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Nucleus, nucleolus Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter nucleic acid binding DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm DNA-directed RNA polymerase II, core complex nucleolus transcription-coupled nucleotide-excision repair transcription, DNA-templated transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter mRNA cleavage zinc ion binding metal ion binding uc009gdt.1 uc009gdt.2 uc009gdt.3 
ENSMUST00000019896.5 Iyd ENSMUST00000019896.5 iodotyrosine deiodinase (from RefSeq NM_027391.4) Dehal1 ENSMUST00000019896.1 ENSMUST00000019896.2 ENSMUST00000019896.3 ENSMUST00000019896.4 IYD1_MOUSE NM_027391 Q9DCX8 uc007ehp.1 uc007ehp.2 uc007ehp.3 Catalyzes the dehalogenation of halotyrosines such as 3- bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5- diiodo-L-tyrosine (By similarity). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:22238141). The scavanged iodide can then reenter the hormone- producing pathways (By similarity). Acts more efficiently on 3-iodo-L- tyrosine than 3,5-diiodo-L-tyrosine (By similarity). Reaction=2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH; Xref=Rhea:RHEA:32479, ChEBI:CHEBI:15378, ChEBI:CHEBI:16382, ChEBI:CHEBI:57506, ChEBI:CHEBI:57783, ChEBI:CHEBI:58315, ChEBI:CHEBI:58349; EC=1.21.1.1; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:32481; Evidence=; Reaction=iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH; Xref=Rhea:RHEA:27453, ChEBI:CHEBI:16382, ChEBI:CHEBI:57783, ChEBI:CHEBI:58315, ChEBI:CHEBI:58349, ChEBI:CHEBI:59898; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:27455; Evidence=; Reaction=3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + NADPH; Xref=Rhea:RHEA:27457, ChEBI:CHEBI:15378, ChEBI:CHEBI:16382, ChEBI:CHEBI:57506, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:59898; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:27459; Evidence=; Reaction=chloride + L-tyrosine + NADP(+) = 3-chloro-L-tyrosine + NADPH; Xref=Rhea:RHEA:70343, ChEBI:CHEBI:17996, ChEBI:CHEBI:57783, ChEBI:CHEBI:58315, ChEBI:CHEBI:58349, ChEBI:CHEBI:189422; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70345; Evidence=; Reaction=bromide + L-tyrosine + NADP(+) = 3-bromo-L-tyrosine + NADPH; Xref=Rhea:RHEA:70347, ChEBI:CHEBI:15858, ChEBI:CHEBI:57783, ChEBI:CHEBI:58315, ChEBI:CHEBI:58349, ChEBI:CHEBI:189423; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70349; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence= Homodimer. Cell membrane ; Single-pass membrane protein Cytoplasmic vesicle membrane Belongs to the nitroreductase family. iodide peroxidase activity nucleoplasm plasma membrane integral component of plasma membrane tyrosine metabolic process FMN binding membrane integral component of membrane oxidoreductase activity cytoplasmic vesicle membrane cytoplasmic vesicle thyroid hormone metabolic process oxidation-reduction process cellular oxidant detoxification uc007ehp.1 uc007ehp.2 uc007ehp.3 
ENSMUST00000019906.6 Vip ENSMUST00000019906.6 vasoactive intestinal polypeptide, transcript variant 1 (from RefSeq NM_011702.3) A0A0R4J003 A0A0R4J003_MOUSE ENSMUST00000019906.1 ENSMUST00000019906.2 ENSMUST00000019906.3 ENSMUST00000019906.4 ENSMUST00000019906.5 NM_011702 Vip uc007egk.1 uc007egk.2 uc007egk.3 uc007egk.4 This gene encodes a neuropeptide of the glucagon/secretin superfamily with potent bronchodilator, immunomodulator and anti-inflammatory properties. The encoded protein is proteolytically processed to generate two structurally similar neuropeptides - vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI). In the digestive tract, VIP stimulates relaxation of enteric smooth muscle, secretion of water and electrolytes, release of insulin and glucagon, and inhibition of gastric acid secretion. In the cardiovascular system, VIP causes coronary vasodilation and stimulates contractility in the heart. Mice lacking VIP exhibit airway hyperresponsiveness and airway inflammation. Male mice lacking VIP exhibit moderate pulmonary arterial hypertension resulting in increased mortality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. Secreted Belongs to the glucagon family. hormone activity extracellular region adenylate cyclase-activating G-protein coupled receptor signaling pathway regulation of protein localization positive regulation of protein catabolic process peptide hormone receptor binding uc007egk.1 uc007egk.2 uc007egk.3 uc007egk.4 
ENSMUST00000019907.8 Fbxo5 ENSMUST00000019907.8 F-box protein 5 (from RefSeq NM_025995.2) ENSMUST00000019907.1 ENSMUST00000019907.2 ENSMUST00000019907.3 ENSMUST00000019907.4 ENSMUST00000019907.5 ENSMUST00000019907.6 ENSMUST00000019907.7 Emi1 FBX5_MOUSE Fbxo5 NM_025995 Q7TSG3 uc007egj.1 uc007egj.2 uc007egj.3 Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:17190794, PubMed:15526037, PubMed:16809773). During mitotic cell cycle plays a role as both substrate and inhibitor of APC- FZR1 complex (PubMed:16809773). During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase. Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment. As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box co-receptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities. Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage- induced cellular senescence (By similarity). During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (PubMed:15526037). Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (PubMed:17190794). Promotes migration and osteogenic differentiation of mesenchymal stem cells (By similarity). Protein modification; protein ubiquitination. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with BTRC; mediates proteolysis by the SCF ubiquitin ligase complex leading to activation of APC in late mitosis and subsequent mitotic progression. Interacts with FZR1/CDH1 and the N-terminal substrate-binding domain of CDC20; prevents APC activation. Also interacts with EVI5 which blocks its phosphorylation by PLK1 and prevents its subsequent binding to BTRC and degradation. Interacts simultaneously with anaphase promoting complex (APC), through at least ANAPC2, CDC23, CDC27, the APC substrate GMNN and the APC activator FZR1. Interacts with UBE2S; interferes with the activity of UBE2S mainly by disrupting the dynamic electrostatic association between the C-terminal tail of UBE2S and ANAPC2 (By similarity). Interacts with RPS6KA2; cooperates to induce the metaphase arrest of early blastomeres; increases and stabilizes interaction of FBXO5 with CDC20 (PubMed:15526037). Nucleus Cytoplasm Cytoplasm, cytoskeleton, spindle Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle. Expressed in oocytes and granulosa cells (PubMed:15526037, PubMed:17190794). Expressed in proliferating cells compartments in hair follicle and skin epidermis, spermatogonia, and intestinal crypts (PubMed:17875940). Detected at the germinal vesicle (GV) stage. During maturation, decreases to barely detectable levels in meiosis I- and meiosis II-stage oocytes. Phosphorylation by CDK2 and subsequently by PLK1 triggers degradation during early mitosis through ubiquitin-mediated proteolysis by the SCF ubiquitin ligase complex containing the F-box protein BTRC. This degradation is necessary for the activation of APC in late mitosis and subsequent mitotic progression (By similarity). Phosphorylated by RPS6KA2; increases and stabilizes interaction with CDC20 (PubMed:15526037). Ubiquitinated by the SCF(BTRC) complex following phosphorylation by PLK1. Undergoes both 'Lys-11' and 'Lys-48'-linked polyubiquitination by APC-FZR1 complex leading to degradation during G1 phase by the proteasome (By similarity). Degraded through the SCF(BTRC) complex; degradation occurs during oocyte maturation, between germinal vesicle breakdown (GVBD) and meiosis I, and is required for the meiosis I- meiosis II transition (PubMed:17190794). Death at the preimplantation stage. Embryos display normal cell proliferation but mitotic progression is severely defective during embryonic cleavage with multipolar spindles and misaligned chromosomes frequently observed. oocyte maturation protein binding nucleus nucleoplasm cytoplasm spindle cytoskeleton regulation of DNA replication cell cycle spindle assembly involved in female meiosis I regulation of mitotic cell cycle positive regulation of cell proliferation positive regulation of G2/M transition of mitotic cell cycle anaphase-promoting complex binding vesicle organization protein ubiquitination protein kinase binding negative regulation of DNA endoreduplication regulation of meiotic nuclear division positive regulation of osteoblast differentiation negative regulation of meiotic nuclear division negative regulation of mitotic metaphase/anaphase transition microtubule polymerization metal ion binding spindle assembly cell division negative regulation of ubiquitin-protein transferase activity positive regulation of meiosis I positive regulation of biomineral tissue development meiotic spindle negative regulation of ubiquitin protein ligase activity positive regulation of mesenchymal stem cell migration ubiquitin ligase inhibitor activity negative regulation of cellular senescence negative regulation of response to DNA damage stimulus uc007egj.1 uc007egj.2 uc007egj.3 
ENSMUST00000019908.9 Mtrf1l ENSMUST00000019908.9 mitochondrial translational release factor 1-like (from RefSeq NM_175374.3) ENSMUST00000019908.1 ENSMUST00000019908.2 ENSMUST00000019908.3 ENSMUST00000019908.4 ENSMUST00000019908.5 ENSMUST00000019908.6 ENSMUST00000019908.7 ENSMUST00000019908.8 NM_175374 Q8BJU9 RF1ML_MOUSE uc007egi.1 uc007egi.2 uc007egi.3 Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG. Mitochondrion The GGQ domain interacts with the peptidyltransferase center (PTC) of the large ribosomal subunit to trigger nascent chain hydrolysis. Methylation of glutamine in the GGQ triplet by HEMK1 is conserved from bacteria to mammals. Belongs to the prokaryotic/mitochondrial release factor family. translation release factor activity mitochondrion translation translational termination translation release factor activity, codon specific ribosome binding mitochondrial translational termination uc007egi.1 uc007egi.2 uc007egi.3 
ENSMUST00000019911.14 Hdac2 ENSMUST00000019911.14 histone deacetylase 2 (from RefSeq NM_008229.2) A0A0R4J008 A0A0R4J008_MOUSE ENSMUST00000019911.1 ENSMUST00000019911.10 ENSMUST00000019911.11 ENSMUST00000019911.12 ENSMUST00000019911.13 ENSMUST00000019911.2 ENSMUST00000019911.3 ENSMUST00000019911.4 ENSMUST00000019911.5 ENSMUST00000019911.6 ENSMUST00000019911.7 ENSMUST00000019911.8 ENSMUST00000019911.9 Hdac2 NM_008229 uc007evf.1 uc007evf.2 uc007evf.3 Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Reaction=H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]; Xref=Rhea:RHEA:69172, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13707, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:35899, ChEBI:CHEBI:137954; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69173; Evidence=; Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA- COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58197; Evidence=; Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl- [protein]; Xref=Rhea:RHEA:58108, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58109; Evidence=; Nucleus Belongs to the histone deacetylase family. HD Type 1 subfamily. negative regulation of transcription from RNA polymerase II promoter chromatin RNA polymerase II repressing transcription factor binding response to amphetamine cardiac muscle hypertrophy histone deacetylase activity nucleus cytoplasm chromatin organization maintenance of chromatin silencing transcription factor binding positive regulation of cell proliferation positive regulation of epithelial to mesenchymal transition positive regulation of receptor biosynthetic process negative regulation of neuron projection development histone deacetylation Sin3 complex NuRD complex hydrolase activity deacetylase activity enzyme binding response to caffeine heat shock protein binding NAD-dependent histone deacetylase activity (H3-K14 specific) response to lipopolysaccharide positive regulation of interleukin-1 production positive regulation of tumor necrosis factor production macromolecular complex protein deacetylase activity cellular response to heat response to nicotine ESC/E(Z) complex response to cocaine response to drug positive regulation of tyrosine phosphorylation of STAT protein histone deacetylase binding negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding positive regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding behavioral response to ethanol positive regulation of oligodendrocyte differentiation NF-kappaB binding response to hyperoxia negative regulation of dendritic spine development cellular response to hydrogen peroxide histone H3 deacetylation cellular response to retinoic acid cellular response to transforming growth factor beta stimulus positive regulation of male mating behavior cellular response to dopamine promoter-specific chromatin binding negative regulation of peptidyl-lysine acetylation uc007evf.1 uc007evf.2 uc007evf.3 
ENSMUST00000019913.15 Frk ENSMUST00000019913.15 fyn-related kinase, transcript variant 2 (from RefSeq NM_010237.3) Bsk ENSMUST00000019913.1 ENSMUST00000019913.10 ENSMUST00000019913.11 ENSMUST00000019913.12 ENSMUST00000019913.13 ENSMUST00000019913.14 ENSMUST00000019913.2 ENSMUST00000019913.3 ENSMUST00000019913.4 ENSMUST00000019913.5 ENSMUST00000019913.6 ENSMUST00000019913.7 ENSMUST00000019913.8 ENSMUST00000019913.9 FRK_MOUSE Iyk NM_010237 Q61364 Q61745 Q922K9 uc007euy.1 uc007euy.2 uc007euy.3 uc007euy.4 uc007euy.5 Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Interacts (via the SH3-domain) with PTEN. Interacts with RB1 (By similarity). Cytoplasm Nucleus Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery. Expressed in intestinal tract, fetal and adult islets of Langerhans, kidney, liver and lung. Mice are viable and do not show any histological abnormalities in epithelial tissues or develop any pathological and/or metabolic disorders associated with the failure of epithelial organs. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. negative regulation of transcription from RNA polymerase II promoter nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding ATP binding nucleus cytoplasm cytosol plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway kinase activity phosphorylation transferase activity cell differentiation extrinsic component of cytoplasmic side of plasma membrane peptidyl-tyrosine autophosphorylation regulation of cell proliferation uc007euy.1 uc007euy.2 uc007euy.3 uc007euy.4 uc007euy.5 
ENSMUST00000019917.6 Rwdd1 ENSMUST00000019917.6 RWD domain containing 1 (from RefSeq NM_025614.3) Dfrp2 ENSMUST00000019917.1 ENSMUST00000019917.2 ENSMUST00000019917.3 ENSMUST00000019917.4 ENSMUST00000019917.5 NM_025614 Q9CQK7 RWDD1_MOUSE uc007eun.1 uc007eun.2 uc007eun.3 Protects DRG2 from proteolytic degradation. Interacts with androgen receptor (By similarity). Interacts with DRG2. Belongs to the RWDD1/GIR2 family. cytoplasmic translation molecular_function cytoplasm polysome cell aging androgen receptor signaling pathway cellular response to oxidative stress cellular response to testosterone stimulus positive regulation of androgen receptor activity uc007eun.1 uc007eun.2 uc007eun.3 
ENSMUST00000019920.13 Clvs2 ENSMUST00000019920.13 clavesin 2, transcript variant 1 (from RefSeq NM_175448.4) CLVS2_MOUSE ENSMUST00000019920.1 ENSMUST00000019920.10 ENSMUST00000019920.11 ENSMUST00000019920.12 ENSMUST00000019920.2 ENSMUST00000019920.3 ENSMUST00000019920.4 ENSMUST00000019920.5 ENSMUST00000019920.6 ENSMUST00000019920.7 ENSMUST00000019920.8 ENSMUST00000019920.9 NM_175448 Q8BG92 Q8BKA5 Rlbp1l2 uc007eue.1 uc007eue.2 uc007eue.3 Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Forms a complex with clathrin heavy chain and gamma-adaptin. Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Early endosome membrane ; Peripheral membrane protein Cytoplasmic vesicle, clathrin-coated vesicle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BG92-1; Sequence=Displayed; Name=2; IsoId=Q8BG92-2; Sequence=VSP_027326, VSP_027327; The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2. Binding to PtdIns(3,5)P2 is not required for localization. endosome Golgi apparatus trans-Golgi network lysosome organization lipid binding membrane clathrin-coated vesicle cytoplasmic vesicle early endosome membrane phosphatidylinositol-3,5-bisphosphate binding uc007eue.1 uc007eue.2 uc007eue.3 
ENSMUST00000019924.9 Hey2 ENSMUST00000019924.9 hairy/enhancer-of-split related with YRPW motif 2 (from RefSeq NM_013904.1) Chf1 ENSMUST00000019924.1 ENSMUST00000019924.2 ENSMUST00000019924.3 ENSMUST00000019924.4 ENSMUST00000019924.5 ENSMUST00000019924.6 ENSMUST00000019924.7 ENSMUST00000019924.8 HEY2_MOUSE Herp Herp1 Hesr2 Hrt2 NM_013904 Q3TZ99 Q8CD44 Q9QUS4 uc007etp.1 uc007etp.2 uc007etp.3 Transcriptional repressor which functions as a downstream effector of Notch signaling in cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY1 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. May self-associate (By similarity). Interacts with ARNT (By similarity). Interacts with GATA4, GATA6, HES1 and HEYL. Interacts with HDAC1, NCOR1 and SIN3A. Nucleus Highly expressed in the aorta, lower expression detected in the heart, brain, kidney, lung, muscle, ovary and testis. Expressed in the developing somites and the ventricles of the heart. Expressed in the otic vesicles between 8.5 dpc and 10.5 dpc. Expressed in the myocardium of the ventricles at 9.5 dpc and in the atrioventricular cushions from 9.5 to 12.5 dpc. At 10.5 dpc, strongly expressed in the spinal nerves, the cranial ganglia and the telencephalon. At 11.5 dpc, expressed in the craniofacial region of the distal part of the maxillary arch, along the rostral mandibular arch and surrounding the lateral nasal processes. Expressed in the midbrain- hindbrain boundary and the posterior edge of the hand- and foot-paddle. Expressed in the mediodorsal region of the telencephalon and the ventricular zone of the ventral spinal cord at 12 dpc, then in the ventral region of the telencephalon and the cortical plate at 15 dpc. Expression in the heart is limited to the compact myocardial layer at 17.5 dpc. Also expressed in the developing retina up to P5, at which point expression decreases. By activation of the Notch signaling pathway. Mice display a spectrum of cardiac malformations including ventricular septal defects, tetralogy of Fallot and tricuspid atresia. The penetrance of the cardiac malformation phenotype varies according to the strain, suggesting the presence of modifier genes. Belongs to the HEY family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding blood vessel development vasculogenesis muscular septum morphogenesis outflow tract morphogenesis atrioventricular valve development pulmonary valve morphogenesis tricuspid valve morphogenesis tricuspid valve formation endocardial cushion to mesenchymal transition involved in heart valve formation cardiac ventricle morphogenesis cardiac left ventricle morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis cardiac muscle hypertrophy DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Notch signaling pathway multicellular organism development pattern specification process heart development transcription factor binding anterior/posterior axis specification anterior/posterior pattern specification positive regulation of heart rate regulation of gene expression positive regulation of gene expression negative regulation of gene expression negative regulation of cardiac muscle cell apoptotic process mesenchymal cell development cardiac muscle hypertrophy in response to stress Sin3 complex transcriptional repressor complex cell differentiation ascending aorta morphogenesis dorsal aorta morphogenesis umbilical cord morphogenesis protein homodimerization activity histone deacetylase binding sequence-specific DNA binding cell fate commitment regulation of auditory receptor cell differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity regulation of neurogenesis ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation cardiac epithelial to mesenchymal transition heart trabecula formation cardiac septum morphogenesis ventricular septum morphogenesis atrial septum morphogenesis negative regulation of transcription initiation from RNA polymerase II promoter labyrinthine layer blood vessel development artery development arterial endothelial cell differentiation cardiac vascular smooth muscle cell development coronary vasculature morphogenesis pulmonary artery morphogenesis Notch signaling involved in heart development protein-DNA complex assembly negative regulation of biomineral tissue development circulatory system development cochlea development vascular smooth muscle cell development negative regulation of transcription regulatory region DNA binding negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation regulation of vasculogenesis uc007etp.1 uc007etp.2 uc007etp.3 
ENSMUST00000019927.7 Trmt11 ENSMUST00000019927.7 tRNA methyltransferase 11, transcript variant 1 (from RefSeq NM_028604.3) E9QKG3 E9QKG3_MOUSE ENSMUST00000019927.1 ENSMUST00000019927.2 ENSMUST00000019927.3 ENSMUST00000019927.4 ENSMUST00000019927.5 ENSMUST00000019927.6 NM_028604 Trmt11 uc007ete.1 uc007ete.2 Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. Interacts with TRMT112. nucleic acid binding methyltransferase activity methylation uc007ete.1 uc007ete.2 
ENSMUST00000019931.12 Lrp11 ENSMUST00000019931.12 low density lipoprotein receptor-related protein 11, transcript variant 1 (from RefSeq NM_172784.4) ENSMUST00000019931.1 ENSMUST00000019931.10 ENSMUST00000019931.11 ENSMUST00000019931.2 ENSMUST00000019931.3 ENSMUST00000019931.4 ENSMUST00000019931.5 ENSMUST00000019931.6 ENSMUST00000019931.7 ENSMUST00000019931.8 ENSMUST00000019931.9 LRP11_MOUSE NM_172784 Q8C7Y7 Q8CB67 uc007ehw.1 uc007ehw.2 uc007ehw.3 uc007ehw.4 uc007ehw.5 Membrane ; Single-pass type I membrane protein Belongs to the LDLR family. cellular_component endocytosis response to heat response to cold response to water deprivation response to mechanical stimulus membrane integral component of membrane multicellular organismal response to stress response to immobilization stress response to starvation phosphoprotein binding uc007ehw.1 uc007ehw.2 uc007ehw.3 uc007ehw.4 uc007ehw.5 
ENSMUST00000019937.5 Sec63 ENSMUST00000019937.5 SEC63 homolog, protein translocation regulator, transcript variant 1 (from RefSeq NM_153055.3) E9QKG1 ENSMUST00000019937.1 ENSMUST00000019937.2 ENSMUST00000019937.3 ENSMUST00000019937.4 NM_153055 Q8VEB9 Q8VHE0 SEC63_MOUSE Sec63l uc007eyx.1 uc007eyx.2 uc007eyx.3 Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (By similarity). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (PubMed:21685914). The ER translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63. Endoplasmic reticulum membrane; Multi-pass membrane protein. Expressed in kidney (at protein level). Knockout mice exhibit very early embryonic lethality before E7.5. Conditional ubiquitous or kidney-specific knockdown results in polycystic liver and kidney phenotypes, respectively. liver development endoplasmic reticulum endoplasmic reticulum membrane SRP-dependent cotranslational protein targeting to membrane posttranslational protein targeting to membrane nitrogen compound metabolic process multicellular organism aging protein transport membrane integral component of membrane posttranslational protein targeting to membrane, translocation Sec62/Sec63 complex uc007eyx.1 uc007eyx.2 uc007eyx.3 
ENSMUST00000019938.11 Nr2e1 ENSMUST00000019938.11 nuclear receptor subfamily 2, group E, member 1 (from RefSeq NM_152229.3) ENSMUST00000019938.1 ENSMUST00000019938.10 ENSMUST00000019938.2 ENSMUST00000019938.3 ENSMUST00000019938.4 ENSMUST00000019938.5 ENSMUST00000019938.6 ENSMUST00000019938.7 ENSMUST00000019938.8 ENSMUST00000019938.9 NM_152229 Nr2e1 Q78ZM1 Q78ZM1_MOUSE uc007eyt.1 uc007eyt.2 uc007eyt.3 Nucleus Belongs to the nuclear hormone receptor family. NR2 subfamily. DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity nucleus regulation of transcription, DNA-templated zinc ion binding steroid hormone mediated signaling pathway sequence-specific DNA binding metal ion binding uc007eyt.1 uc007eyt.2 uc007eyt.3 
ENSMUST00000019939.12 Snx3 ENSMUST00000019939.12 sorting nexin 3 (from RefSeq NM_017472.4) ENSMUST00000019939.1 ENSMUST00000019939.10 ENSMUST00000019939.11 ENSMUST00000019939.2 ENSMUST00000019939.3 ENSMUST00000019939.4 ENSMUST00000019939.5 ENSMUST00000019939.6 ENSMUST00000019939.7 ENSMUST00000019939.8 ENSMUST00000019939.9 NM_017472 Q78ZM0 Q78ZM0_MOUSE Snx3 uc007eyr.1 uc007eyr.2 uc007eyr.3 uc007eyr.4 Cytoplasmic vesicle, phagosome Endosome Belongs to the sorting nexin family. cytoplasm early endosome cytosol response to bacterium endosome membrane membrane invagination protein phosphatase binding protein to membrane docking regulation of Wnt signaling pathway clathrin-coated vesicle retromer complex early endosome membrane early phagosome phosphatidylinositol-3-phosphate binding phosphatidylinositol binding negative regulation of protein catabolic process negative regulation of viral entry into host cell negative regulation of phagocytosis negative regulation of protein transport intralumenal vesicle formation phosphatidylinositol phosphate binding negative regulation of early endosome to late endosome transport uc007eyr.1 uc007eyr.2 uc007eyr.3 uc007eyr.4 
ENSMUST00000019944.9 Adat2 ENSMUST00000019944.9 adenosine deaminase, tRNA-specific 2 (from RefSeq NM_025748.4) ADAT2_MOUSE Deadc1 ENSMUST00000019944.1 ENSMUST00000019944.2 ENSMUST00000019944.3 ENSMUST00000019944.4 ENSMUST00000019944.5 ENSMUST00000019944.6 ENSMUST00000019944.7 ENSMUST00000019944.8 NM_025748 Q6P6J0 Q9CX14 uc007ela.1 uc007ela.2 uc007ela.3 uc007ela.4 Probably participates in deamination of adenosine-34 to inosine in many tRNAs. Reaction=adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+); Xref=Rhea:RHEA:43168, Rhea:RHEA-COMP:10373, Rhea:RHEA- COMP:10374, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.33; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily. tRNA wobble adenosine to inosine editing catalytic activity tRNA processing tRNA-specific adenosine deaminase activity zinc ion binding hydrolase activity metal ion binding tRNA-specific adenosine-34 deaminase activity tRNA-specific adenosine-34 deaminase complex uc007ela.1 uc007ela.2 uc007ela.3 uc007ela.4 
ENSMUST00000019945.15 Pex3 ENSMUST00000019945.15 peroxisomal biogenesis factor 3, transcript variant 1 (from RefSeq NM_019961.3) ENSMUST00000019945.1 ENSMUST00000019945.10 ENSMUST00000019945.11 ENSMUST00000019945.12 ENSMUST00000019945.13 ENSMUST00000019945.14 ENSMUST00000019945.2 ENSMUST00000019945.3 ENSMUST00000019945.4 ENSMUST00000019945.5 ENSMUST00000019945.6 ENSMUST00000019945.7 ENSMUST00000019945.8 ENSMUST00000019945.9 NM_019961 PEX3_MOUSE Q9QXY9 uc007eky.1 uc007eky.2 uc007eky.3 uc007eky.4 Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes. Interacts with PEX19. Peroxisome membrane ; Multi-pass membrane protein Identified in all tissues analyzed, with the strongest expression in liver and in testis. Belongs to the peroxin-3 family. nucleoplasm peroxisome peroxisomal membrane integral component of peroxisomal membrane endoplasmic reticulum cytosol integral component of plasma membrane peroxisome organization lipid binding membrane integral component of membrane peroxisome membrane biogenesis protein binding, bridging macromolecular complex protein-lipid complex protein import into peroxisome membrane protein dimerization activity uc007eky.1 uc007eky.2 uc007eky.3 uc007eky.4 
ENSMUST00000019950.6 Ltv1 ENSMUST00000019950.6 LTV1 ribosome biogenesis factor (from RefSeq NM_181470.4) ENSMUST00000019950.1 ENSMUST00000019950.2 ENSMUST00000019950.3 ENSMUST00000019950.4 ENSMUST00000019950.5 LTV1_MOUSE NM_181470 Q6NSQ7 Q9D0F5 uc007ekp.1 uc007ekp.2 uc007ekp.3 uc007ekp.4 Essential for ribosome biogenesis. Belongs to the LTV1 family. ribosomal small subunit export from nucleus nucleus nucleoplasm cytosol preribosome, small subunit precursor late endosome membrane EGO complex ribosomal small subunit biogenesis uc007ekp.1 uc007ekp.2 uc007ekp.3 uc007ekp.4 
ENSMUST00000019954.6 Zc2hc1b ENSMUST00000019954.6 zinc finger, C2HC-type containing 1B (from RefSeq NM_029172.1) B9EHC9 B9EHC9_MOUSE ENSMUST00000019954.1 ENSMUST00000019954.2 ENSMUST00000019954.3 ENSMUST00000019954.4 ENSMUST00000019954.5 Fam164b NM_029172 Zc2hc1b uc007eko.1 uc007eko.2 uc007eko.3 uc007eko.4 uc007eko.1 uc007eko.2 uc007eko.3 uc007eko.4 
ENSMUST00000019962.15 Cd164 ENSMUST00000019962.15 CD164 antigen (from RefSeq NM_016898.2) ENSMUST00000019962.1 ENSMUST00000019962.10 ENSMUST00000019962.11 ENSMUST00000019962.12 ENSMUST00000019962.13 ENSMUST00000019962.14 ENSMUST00000019962.2 ENSMUST00000019962.3 ENSMUST00000019962.4 ENSMUST00000019962.5 ENSMUST00000019962.6 ENSMUST00000019962.7 ENSMUST00000019962.8 ENSMUST00000019962.9 MUC24_MOUSE NM_016898 Q3UM47 Q9R0L9 Q9Z317 uc007exv.1 uc007exv.2 uc007exv.3 Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion (By similarity). Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes. Interacts with CXCR4. Lysosome membrane ; Single-pass type I membrane protein Endosome membrane ; Single-pass type I membrane protein Cell membrane ; Single-pass type I membrane protein Expressed at high levels in the submaxillary gland and kidney, at moderate levels in the brain, heart, lung, liver, intestine, testis, muscle and bone marrow, and at low levels in the pancreas, spleen and thymus. In the ear, expressed in the inner and outer hair cells of the organ of Corti, cells of Kolliker's organ, cells in the lateral cochlear wall behind the spiral prominence and cells of the stria vascularis (PubMed:26197441). During embryogenesis, expression in found in all stages examined, with the highest levels of expression at early stages (8.5 dpc) and moderate levels of expression being found at mid- to late stages of embryogenesis. Expressed during early stages of skeletal muscle development. At embryonic stages 9.5 dpc and 10.5 dpc, expressed strongly in the dorsal somite (the structure of origin for skeletal muscle precursors). It is also expressed at later stages of muscle development;. Highly N- and O-glycosylated; contains sialic acid. Belongs to the CD164 family. protein binding lysosome lysosomal membrane endosome plasma membrane cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules muscle organ development endosome membrane membrane integral component of membrane cytoplasmic vesicle uc007exv.1 uc007exv.2 uc007exv.3 
ENSMUST00000019965.13 Smpd2 ENSMUST00000019965.13 sphingomyelin phosphodiesterase 2, neutral (from RefSeq NM_009213.2) ENSMUST00000019965.1 ENSMUST00000019965.10 ENSMUST00000019965.11 ENSMUST00000019965.12 ENSMUST00000019965.2 ENSMUST00000019965.3 ENSMUST00000019965.4 ENSMUST00000019965.5 ENSMUST00000019965.6 ENSMUST00000019965.7 ENSMUST00000019965.8 ENSMUST00000019965.9 NM_009213 NSMA_MOUSE O70572 Smpd2 uc007ext.1 uc007ext.2 uc007ext.3 This gene encodes a protein with similarity to the human nSMase1 protein. In humans, the nSMase1 protein was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010978.1, AJ222800.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine (PubMed:9520418). Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo (By similarity). Also acts on 1-acyl-2-lyso-sn-glycero- 3-phosphocholine (lyso-PC) and sphingosylphosphocholine (By similarity). Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:295975; EC=3.1.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19254; Evidence=; Reaction=an N-(acyl)-sphingosylphosphocholine + H2O = an N-acyl- sphingoid base + H(+) + phosphocholine; Xref=Rhea:RHEA:45300, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64583, ChEBI:CHEBI:83273, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45301; Evidence=; Reaction=1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O- octadecyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:39923, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74001, ChEBI:CHEBI:75216, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39924; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:75542, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41120; Evidence=; Reaction=a sphingosylphosphocholine + H2O = a sphingoid base + H(+) + phosphocholine; Xref=Rhea:RHEA:45296, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:84410, ChEBI:CHEBI:85171, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45297; Evidence=; Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O- hexadecyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:36087, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:34115, ChEBI:CHEBI:64496, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36088; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by arachidonic acid. Kinetic parameters: KM=15 uM for sphingomyelin (at pH 7.4 and 37 degrees Celsius) ; Vmax=10 umol/h/mg enzyme with sphingomyelin as substrate (at pH 7.4 and 37 degrees Celsius) ; pH dependence: Optimum pH is 6.5-7.5. ; Lipid metabolism; sphingolipid metabolism. Cell membrane ; Multi-pass membrane protein Although widely expressed in all tissues examined, except the spleen, high enzymatic activity occurs only in the brain. Mice lacking Smpd2 and Smpd3 are completely devoid of neutral SMase activity but do not developed sphingomyelin storage abnormalities. Belongs to the neutral sphingomyelinase family. sphingomyelin phosphodiesterase activity caveola lipid metabolic process sphingolipid metabolic process sphingomyelin metabolic process sphingomyelin catabolic process response to mechanical stimulus membrane integral component of membrane hydrolase activity intracellular signal transduction positive regulation of apoptotic process ceramide biosynthetic process metal ion binding uc007ext.1 uc007ext.2 uc007ext.3 
ENSMUST00000019967.16 Mical1 ENSMUST00000019967.16 microtubule associated monooxygenase, calponin and LIM domain containing 1, transcript variant 1 (from RefSeq NM_138315.2) D3Z4C6 E9PXR1 ENSMUST00000019967.1 ENSMUST00000019967.10 ENSMUST00000019967.11 ENSMUST00000019967.12 ENSMUST00000019967.13 ENSMUST00000019967.14 ENSMUST00000019967.15 ENSMUST00000019967.2 ENSMUST00000019967.3 ENSMUST00000019967.4 ENSMUST00000019967.5 ENSMUST00000019967.6 ENSMUST00000019967.7 ENSMUST00000019967.8 ENSMUST00000019967.9 MICA1_MOUSE Mical NM_138315 Nical Q3TB77 Q3TBH9 Q3TX89 Q8VDP3 uc007exn.1 uc007exn.2 uc007exn.3 Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (By similarity). Reaction=H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl- (R)-S-oxide-[F-actin] + NADP(+); Xref=Rhea:RHEA:51308, Rhea:RHEA- COMP:12953, Rhea:RHEA-COMP:12956, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16044, ChEBI:CHEBI:45764, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.225; Evidence= Reaction=H(+) + NADPH + O2 = H2O2 + NADP(+); Xref=Rhea:RHEA:11260, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.6.3.1; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Kinetic parameters: KM=9.3 uM for actin (for a monooxygenase domain construct) ; KM=28.8 uM for NADPH (for a monooxygenase domain construct) ; Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A and RAB10 can bind 2 molecules of the Rab proteins simultaneously (By similarity). Interacts with STK38 and STK38L. Interacts with GRAF1/ARHGAP26, GRAF2/ARHGAP10, RAB8A, RAB8B and RAB10; may bind simultaneously to GRAFs and Rabs and connects GRAFs to Rabs (By similarity). Does not interact with RAB1 and RAB11A (By similarity). Q8VDP3; Q91VJ4: Stk38; NbExp=9; IntAct=EBI-4394891, EBI-2527046; Q8VDP3; A4GW50: Stk38l; Xeno; NbExp=2; IntAct=EBI-4394891, EBI-4404035; Cytoplasm Cytoplasm, cytoskeleton Endosome membrane Midbody Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VDP3-1; Sequence=Displayed; Name=2; IsoId=Q8VDP3-2; Sequence=VSP_042591; Name=3; IsoId=Q8VDP3-3; Sequence=VSP_042592; Expressed in the postnatal and adult hippocampus; found in dentate gyrus, the polymorphic layer, cornu ammonis (CA) 1-3 and in mossy fibers of the striatum lucidum. In adult hippocampus strongly expressed in CA3 pyramidial neurons. The C-terminal coiled coil part contains the plexin-interacting region. The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab13 and Rab15 (in their GTP- bound forms). Belongs to the Mical family. The reaction mechanism is subject to discussion. Some work suggest MICAL enzymes directly oxidize actin methionine residues to produce methionine-(R)-S-oxide. Other publications suggest that the enzyme functions as a NADPH oxidase producing H(2)O(2) (EC 1.6.3.1) and that it is the produced H(2)O(2) that is responsible for the methionine-(R)-S-oxide production. negative regulation of protein phosphorylation actin binding monooxygenase activity protein binding cytoplasm microtubule organizing center cytoskeleton NAD(P)H oxidase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen SH3 domain binding Rab GTPase binding sulfur oxidation protein kinase binding actin cytoskeleton organization actin filament depolymerization midbody filamentous actin negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process intercellular bridge metal ion binding oxidation-reduction process FAD binding regulation of regulated secretory pathway hippocampal mossy fiber expansion uc007exn.1 uc007exn.2 uc007exn.3 
ENSMUST00000019974.5 Rab32 ENSMUST00000019974.5 RAB32, member RAS oncogene family (from RefSeq NM_026405.3) ENSMUST00000019974.1 ENSMUST00000019974.2 ENSMUST00000019974.3 ENSMUST00000019974.4 NM_026405 Q3TXU7 Q8BVD3 Q91YN4 Q9CZE3 RAB32_MOUSE uc007ejg.1 uc007ejg.2 uc007ejg.3 Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). Plays an important role in the control of melanin production and melanosome biogenesis (By similarity). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560). Regulated by a guanine nucleotide-exchange factor (GEF) and a GTPase-activating protein (GAP) and alternates between an inactive GDP-bound and an active GTP-bound form. The BLOC-3 complex composed of HPS1 and HPS4 acts as its GEF, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. SGSM2 acts as its GAP and inactivates it by stimulating its GTPase activity (PubMed:26620560). Interacts with ANKRD27 (PubMed:19403694, PubMed:21187289). A decreased interaction with ANKRD27 seen in the presence of SGSM2 (By similarity). Mitochondrion Mitochondrion outer membrane ; Lipid-anchor Cytoplasmic vesicle, phagosome Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side Melanosome Melanosome membrane Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization. Widely expressed with highest levels in liver. Strong expression also found in melanocyte, platelet, mast cell and fibroblast cell lines. In the embryo, highest levels occur at day 7. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity protein binding GTP binding mitochondrion mitochondrial outer membrane early endosome endoplasmic reticulum Golgi apparatus trans-Golgi network intracellular protein transport mitochondrion organization membrane vesicle-mediated transport antigen processing and presentation phagocytic vesicle membrane GTP-dependent protein binding cytoplasmic vesicle vesicle Rab protein signal transduction melanosome membrane endosome to melanosome transport AP-1 adaptor complex binding AP-3 adaptor complex binding BLOC-2 complex binding melanosome ER-mitochondrion membrane contact site phagocytic vesicle protein localization to membrane phagosome maturation melanosome assembly uc007ejg.1 uc007ejg.2 uc007ejg.3 
ENSMUST00000019975.14 Wasf1 ENSMUST00000019975.14 WASP family, member 1, transcript variant 1 (from RefSeq NM_031877.3) ENSMUST00000019975.1 ENSMUST00000019975.10 ENSMUST00000019975.11 ENSMUST00000019975.12 ENSMUST00000019975.13 ENSMUST00000019975.2 ENSMUST00000019975.3 ENSMUST00000019975.4 ENSMUST00000019975.5 ENSMUST00000019975.6 ENSMUST00000019975.7 ENSMUST00000019975.8 ENSMUST00000019975.9 NM_031877 Q8R5H6 Q91W51 Q9ERQ9 WASF1_MOUSE Wave1 uc007exi.1 uc007exi.2 uc007exi.3 uc007exi.4 Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705). Also involved in the regulation of mitochondrial dynamics (By similarity). Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex. Interacts with ABI1 (via N-terminus). Interacts with SORBS2; this interaction greatly enhances phosphorylation by ABL1 and dephosphorylation by PTPN12 and might mediate partial to focal adhesion sites (By similarity). Q8R5H6; Q80TE2: Pcdh10; NbExp=3; IntAct=EBI-774719, EBI-6661550; Q8R5H6; P26450: Pik3r1; NbExp=2; IntAct=EBI-774719, EBI-641764; Cytoplasm, cytoskeleton Synapse Cell junction, focal adhesion Note=Dot- like pattern in the cytoplasm. Concentrated in Rac-regulated membrane- ruffling areas. Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2. In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (PubMed:27605705). Highly expressed in brain. Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain. Belongs to the SCAR/WAVE family. actin binding protein binding cytoplasm mitochondrion mitochondrial outer membrane cytoskeleton focal adhesion receptor-mediated endocytosis Rac protein signal transduction lamellipodium actin cytoskeleton organization cell junction neuron projection development SCAR complex dendrite cytoplasm macromolecular complex synapse Rac GTPase binding protein kinase A binding positive regulation of neurotrophin TRK receptor signaling pathway lamellipodium morphogenesis dendrite extension postsynapse modification of postsynaptic actin cytoskeleton dendritic transport of mitochondrion cellular response to brain-derived neurotrophic factor stimulus positive regulation of Arp2/3 complex-mediated actin nucleation uc007exi.1 uc007exi.2 uc007exi.3 uc007exi.4 
ENSMUST00000019977.8 Ddo ENSMUST00000019977.8 D-aspartate oxidase, transcript variant 1 (from RefSeq NM_027442.6) ENSMUST00000019977.1 ENSMUST00000019977.2 ENSMUST00000019977.3 ENSMUST00000019977.4 ENSMUST00000019977.5 ENSMUST00000019977.6 ENSMUST00000019977.7 NM_027442 OXDD_MOUSE Q3TT69 Q8R2R2 Q922Z0 uc007exa.1 uc007exa.2 uc007exa.3 Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate. Reaction=D-aspartate + H2O + O2 = H2O2 + NH4(+) + oxaloacetate; Xref=Rhea:RHEA:12512, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:16452, ChEBI:CHEBI:28938, ChEBI:CHEBI:29990; EC=1.4.3.1; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Name=6-hydroxy-FAD; Xref=ChEBI:CHEBI:60470; Evidence=; Peroxisome Belongs to the DAMOX/DASOX family. D-amino-acid oxidase activity peroxisome cytosol aspartate metabolic process aspartate catabolic process insemination grooming behavior D-aspartate oxidase activity oxidoreductase activity D-amino acid catabolic process hormone metabolic process D-amino acid metabolic process cofactor binding oxidation-reduction process FAD binding uc007exa.1 uc007exa.2 uc007exa.3 
ENSMUST00000019982.9 Gtf3c6 ENSMUST00000019982.9 general transcription factor IIIC, polypeptide 6, alpha, transcript variant 1 (from RefSeq NM_001359491.1) ENSMUST00000019982.1 ENSMUST00000019982.2 ENSMUST00000019982.3 ENSMUST00000019982.4 ENSMUST00000019982.5 ENSMUST00000019982.6 ENSMUST00000019982.7 ENSMUST00000019982.8 Gtf3c6 NM_001359491 Q9DB36 Q9DB36_MOUSE uc007ewq.1 uc007ewq.2 uc007ewq.3 uc007ewq.1 uc007ewq.2 uc007ewq.3 
ENSMUST00000019986.13 Rev3l ENSMUST00000019986.13 REV3 like, DNA directed polymerase zeta catalytic subunit (from RefSeq NM_011264.3) E9Q1X0 ENSMUST00000019986.1 ENSMUST00000019986.10 ENSMUST00000019986.11 ENSMUST00000019986.12 ENSMUST00000019986.2 ENSMUST00000019986.3 ENSMUST00000019986.4 ENSMUST00000019986.5 ENSMUST00000019986.6 ENSMUST00000019986.7 ENSMUST00000019986.8 ENSMUST00000019986.9 NM_011264 Polz Q61493 Q9JMD6 Q9QWX6 REV3L_MOUSE Sez4 uc007ewd.1 uc007ewd.2 uc007ewd.3 uc007ewd.4 Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Heterodimer with MAD2L2. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta. Nucleus The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes. Belongs to the DNA polymerase type-B family. nucleotide binding double-strand break repair via homologous recombination nucleic acid binding DNA binding DNA-directed DNA polymerase activity nucleus nucleolus DNA replication DNA repair cellular response to DNA damage stimulus zeta DNA polymerase complex transferase activity nucleotidyltransferase activity translesion synthesis error-prone translesion synthesis metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding nucleic acid phosphodiester bond hydrolysis 3'-5' exonuclease activity uc007ewd.1 uc007ewd.2 uc007ewd.3 uc007ewd.4 
ENSMUST00000019987.7 Traf3ip2 ENSMUST00000019987.7 TRAF3 interacting protein 2 (from RefSeq NM_134000.3) CIKS_MOUSE ENSMUST00000019987.1 ENSMUST00000019987.2 ENSMUST00000019987.3 ENSMUST00000019987.4 ENSMUST00000019987.5 ENSMUST00000019987.6 NM_134000 Q8BH33 Q8N7N6 Traf3ip2 uc007ewa.1 uc007ewa.2 E3 ubiquitin ligase that catalyzes 'Lys63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (By similarity). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (By similarity). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys63'- linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta (By similarity). Interacts with TRAF6; this interaction is direct (PubMed:19825828). Interacts with IL17RA and IL17RC (PubMed:19825828, PubMed:33723527). Interacts with IL17RB (By similarity). Q8N7N6; Q9R0T8: Ikbke; NbExp=3; IntAct=EBI-646165, EBI-6664658; Q8N7N6; P70191: Traf5; NbExp=3; IntAct=EBI-646165, EBI-523899; Q8N7N6; P70196: Traf6; NbExp=4; IntAct=EBI-646165, EBI-448028; B cell apoptotic process positive regulation of defense response to virus by host receptor binding protein binding humoral immune response positive regulation of I-kappaB kinase/NF-kappaB signaling immunoglobulin secretion uc007ewa.1 uc007ewa.2 
ENSMUST00000019991.8 Tube1 ENSMUST00000019991.8 tubulin, epsilon 1 (from RefSeq NM_028006.2) ENSMUST00000019991.1 ENSMUST00000019991.2 ENSMUST00000019991.3 ENSMUST00000019991.4 ENSMUST00000019991.5 ENSMUST00000019991.6 ENSMUST00000019991.7 NM_028006 Q9D6T1 TBE_MOUSE uc007evu.1 uc007evu.2 Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Associated with pericentriolar material. Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle GTPase activity structural constituent of cytoskeleton GTP binding cytoplasm microtubule organizing center cytoskeleton microtubule microtubule-based process uc007evu.1 uc007evu.2 
ENSMUST00000019992.6 Lama4 ENSMUST00000019992.6 laminin, alpha 4 (from RefSeq NM_010681.4) ENSMUST00000019992.1 ENSMUST00000019992.2 ENSMUST00000019992.3 ENSMUST00000019992.4 ENSMUST00000019992.5 LAMA4_MOUSE NM_010681 O88785 P70409 P97927 Q14BF2 uc007evq.1 uc007evq.2 uc007evq.3 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-4 is a subunit of laminin-8 (laminin-411), laminin-9 (laminin-421) and laminin-14 (laminin-423). Secreted, extracellular space, extracellular matrix, basement membrane. Secreted Note=Major basement membrane component. Strongly expressed in peripheral nerves, cardiac muscle, fat, dermis, lung stroma, aortic endothelium, endocardium and endothelium of blood vessels in skin and brain. The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. Domain G is globular. blood vessel development receptor binding extracellular matrix structural constituent extracellular region basement membrane extracellular space cell adhesion regulation of cell adhesion regulation of cell migration neuromuscular junction synaptic cleft regulation of embryonic development brown fat cell differentiation uc007evq.1 uc007evq.2 uc007evq.3 
ENSMUST00000019994.14 Popdc3 ENSMUST00000019994.14 popeye domain containing 3 (from RefSeq NM_024286.1) ENSMUST00000019994.1 ENSMUST00000019994.10 ENSMUST00000019994.11 ENSMUST00000019994.12 ENSMUST00000019994.13 ENSMUST00000019994.2 ENSMUST00000019994.3 ENSMUST00000019994.4 ENSMUST00000019994.5 ENSMUST00000019994.6 ENSMUST00000019994.7 ENSMUST00000019994.8 ENSMUST00000019994.9 NM_024286 POPD3_MOUSE Pop3 Q1RME0 Q9ES81 uc007ezy.1 uc007ezy.2 uc007ezy.3 May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding. May play a role in the regulation of KCNK2-mediated current amplitude (By similarity). Membrane ; Multi-pass membrane protein Expressed in cardiac and skeletal muscle. Belongs to the popeye family. nucleotide binding heart development skeletal muscle tissue development membrane integral component of membrane cAMP binding sarcolemma regulation of membrane potential striated muscle cell differentiation uc007ezy.1 uc007ezy.2 uc007ezy.3 
ENSMUST00000019997.11 Tnfaip3 ENSMUST00000019997.11 tumor necrosis factor, alpha-induced protein 3, transcript variant 1 (from RefSeq NM_009397.3) ENSMUST00000019997.1 ENSMUST00000019997.10 ENSMUST00000019997.2 ENSMUST00000019997.3 ENSMUST00000019997.4 ENSMUST00000019997.5 ENSMUST00000019997.6 ENSMUST00000019997.7 ENSMUST00000019997.8 ENSMUST00000019997.9 NM_009397 Q3U968 Q60769 TNAP3_MOUSE Tnfip3 uc007enb.1 uc007enb.2 uc007enb.3 uc007enb.4 Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL- 1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)- mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of pro- inflammatory cytokines and IFN beta in LPS-tolerized macrophages. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By similarity). Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6 (By similarity). Q60769; Q9CYZ8: Ssbp2; NbExp=2; IntAct=EBI-646595, EBI-309962; Q60769; Q9WUU8: Tnip1; NbExp=4; IntAct=EBI-646595, EBI-6126152; Q60769; P39429: Traf2; NbExp=3; IntAct=EBI-646595, EBI-520016; Q60769; P01375: TNF; Xeno; NbExp=2; IntAct=EBI-646595, EBI-359977; Cytoplasm Nucleus Lysosome Found in most tissues during development. Strikingly high levels are found in lymphoid organs, including the thymus, spleen, and gut-associated lymphoid tissue. Constitutively expressed in immature and mature thymocyte subpopulations as well as in resting peripheral T-cells; activation of these leads to down- regulation. By cytokines. TNF-alpha may regulate expression in the thymus. Up-regulated in presence of reactive oxygen species (ROS), like H(2)O(2), in LPS-tolerized macrophages. The A20-type zinc fingers mediate the ubiquitin ligase activity. The A20-type zinc finger 4 selectively recognizes 'Lys-63'- linked polyubiquitin. The A20-type zinc finger 4-7 are sufficient to bind polyubiquitin (By similarity). The OTU domain mediates the deubiquitinase activity. Belongs to the peptidase C64 family. B-1 B cell homeostasis protease binding response to molecule of bacterial origin marginal zone B cell differentiation negative regulation of granuloma formation regulation of germinal center formation regulation of immunoglobulin production negative regulation of chronic inflammatory response DNA binding catalytic activity ubiquitin-protein transferase activity thiol-dependent ubiquitin-specific protease activity protein binding nucleus cytoplasm lysosome proteolysis apoptotic process inflammatory response cytoskeleton organization metabolic process peptidase activity cysteine-type peptidase activity zinc ion binding response to wounding negative regulation of autophagy cell migration protein ubiquitination protein deubiquitination transferase activity hydrolase activity kinase binding positive regulation of Wnt signaling pathway negative regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity response to muramyl dipeptide negative regulation of interleukin-1 beta production negative regulation of interleukin-2 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of heterotypic cell-cell adhesion negative regulation of toll-like receptor 3 signaling pathway negative regulation of toll-like receptor 5 signaling pathway protein K29-linked deubiquitination protein K11-linked deubiquitination thiol-dependent ubiquitinyl hydrolase activity identical protein binding negative regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding intracellular membrane-bounded organelle protein self-association regulation of innate immune response positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of innate immune response metal ion binding negative regulation of smooth muscle cell proliferation negative regulation of interleukin-1 beta secretion negative regulation of inflammatory response negative regulation of B cell activation negative regulation of cell death Lys63-specific deubiquitinase activity cellular response to hydrogen peroxide negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway K63-linked polyubiquitin binding protein K63-linked deubiquitination protein K48-linked ubiquitination protein K48-linked deubiquitination cellular response to lipopolysaccharide protein deubiquitination involved in ubiquitin-dependent protein catabolic process tolerance induction to lipopolysaccharide establishment of protein localization to vacuole negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of cellular protein catabolic process protein K33-linked deubiquitination positive regulation of hepatocyte proliferation negative regulation of CD40 signaling pathway negative regulation of endothelial cell apoptotic process uc007enb.1 uc007enb.2 uc007enb.3 uc007enb.4 
ENSMUST00000019998.9 Perp ENSMUST00000019998.9 PERP, TP53 apoptosis effector (from RefSeq NM_022032.4) ENSMUST00000019998.1 ENSMUST00000019998.2 ENSMUST00000019998.3 ENSMUST00000019998.4 ENSMUST00000019998.5 ENSMUST00000019998.6 ENSMUST00000019998.7 ENSMUST00000019998.8 Krtcap1 NM_022032 PERP_MOUSE Q9JI77 Q9JK95 uc007emz.1 uc007emz.2 uc007emz.3 uc007emz.4 Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway. Plays a role as an effector in the TP53-dependent apoptotic pathway. Cell junction, desmosome Cell membrane ; Multi-pass membrane protein Note=Associated with desmosomes. Expressed in the stratified squamous skin epithelium of the skin and the tongue, but not in simple epithelia (at protein level). Expressed in apoptotic cells. Expressed in developing skin during and after the stratification process from 9.5 to 15.5 dpc (at protein level). Expressed in ectoderm of the developing branchial arches and limb buds from the 9.5 to 10.5 dpc. Expressed in epithelia of the oral mucosa and skin from the 16.5 to 18.5 dpc. Up-regulated by UV irradiation, doxorubicin (DOX) and TP53 in embryo fibroblasts. Deficient mice exhibit postnatal lethality and defects in stratified epithelia. Belongs to the TMEM47 family. desmosome organization mitochondrion Golgi apparatus plasma membrane integral component of plasma membrane apoptotic process cell adhesion Notch signaling pathway membrane integral component of membrane cell junction desmosome heterotypic cell-cell adhesion positive regulation of proteolysis intrinsic apoptotic signaling pathway by p53 class mediator amelogenesis activation of cysteine-type endopeptidase activity uc007emz.1 uc007emz.2 uc007emz.3 uc007emz.4 
ENSMUST00000020000.7 Hebp2 ENSMUST00000020000.7 heme binding protein 2 (from RefSeq NM_019487.3) ENSMUST00000020000.1 ENSMUST00000020000.2 ENSMUST00000020000.3 ENSMUST00000020000.4 ENSMUST00000020000.5 ENSMUST00000020000.6 HEBP2_MOUSE NM_019487 Q9WU63 Soul uc007emk.1 uc007emk.2 uc007emk.3 Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions (By similarity). May have low affinity for heme (PubMed:15518569). Monomer. Interacts with LRPPRC. May interact with BCL2L1; an interaction with BCL2L1 was observed using a peptide, but not with the full-length protein. The full-length protein would have to undergo a major conformation change for the interaction to occur. Interacts with PDCD6. Cytoplasm Mitochondrion Note=Mainly localized to the cytoplasm with a much lower abundance in the mitochondrion. Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Belongs to the HEBP family. Has been described as heme-binding protein (PubMed:15518569) in mouse, but the human protein does not bind hemin. His-42, a residue essential for heme binding in mouse, is not conserved in all orthologs, or in the heme-binding family member HEBP1. cytoplasm mitochondrion negative regulation of mitochondrial membrane potential positive regulation of necrotic cell death heme binding positive regulation of mitochondrial membrane permeability uc007emk.1 uc007emk.2 uc007emk.3 
ENSMUST00000020002.9 Abracl ENSMUST00000020002.9 ABRA C-terminal like, transcript variant 1 (from RefSeq NM_028440.1) 3110003A17Rik Abracl E9QMV2 E9QMV2_MOUSE ENSMUST00000020002.1 ENSMUST00000020002.2 ENSMUST00000020002.3 ENSMUST00000020002.4 ENSMUST00000020002.5 ENSMUST00000020002.6 ENSMUST00000020002.7 ENSMUST00000020002.8 NM_028440 uc007ely.1 uc007ely.2 uc007ely.3 uc007ely.4 Belongs to the costars family. uc007ely.1 uc007ely.2 uc007ely.3 uc007ely.4 
ENSMUST00000020003.15 Fam184a ENSMUST00000020003.15 family with sequence similarity 184, member A (from RefSeq NM_001081428.2) E9PW83 E9PW83_MOUSE ENSMUST00000020003.1 ENSMUST00000020003.10 ENSMUST00000020003.11 ENSMUST00000020003.12 ENSMUST00000020003.13 ENSMUST00000020003.14 ENSMUST00000020003.2 ENSMUST00000020003.3 ENSMUST00000020003.4 ENSMUST00000020003.5 ENSMUST00000020003.6 ENSMUST00000020003.7 ENSMUST00000020003.8 ENSMUST00000020003.9 Fam184a NM_001081428 uc007fbu.1 uc007fbu.2 uc007fbu.3 uc007fbu.4 molecular_function biological_process uc007fbu.1 uc007fbu.2 uc007fbu.3 uc007fbu.4 
ENSMUST00000020004.8 Asf1a ENSMUST00000020004.8 anti-silencing function 1A histone chaperone (from RefSeq NM_025541.3) ASF1A_MOUSE Asf1a ENSMUST00000020004.1 ENSMUST00000020004.2 ENSMUST00000020004.3 ENSMUST00000020004.4 ENSMUST00000020004.5 ENSMUST00000020004.6 ENSMUST00000020004.7 NM_025541 Q9CQE6 uc007fbr.1 uc007fbr.2 uc007fbr.3 uc007fbr.4 Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51. Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1 and UBN1. Interacts with CDAN1. Found in a cytosolic complex with IPO4 and histones H3 and H4. Interacts with CREBBP. Nucleus Chromosome Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase. TLK2-mediated phosphorylation at Ser- 192 prevents proteasome-dependent degradation. Phosphorylation at Ser- 192 by PRKDC in response to DNA damage promotes the histone chaperone activity and ability to replace histones at double-strand breaks (DSBs) at stalled or collapsed replication forks, leading to RAD51 recruitment. Embryonic lethality at mid-gestation (9.5 dpc). Belongs to the ASF1 family. nuclear chromatin osteoblast differentiation chromatin binding nucleus nucleoplasm DNA repair chromatin organization chromatin assembly or disassembly nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly macromolecular complex histone binding muscle cell differentiation uc007fbr.1 uc007fbr.2 uc007fbr.3 uc007fbr.4 
ENSMUST00000020008.10 Gopc ENSMUST00000020008.10 golgi associated PDZ and coiled-coil motif containing, transcript variant 2 (from RefSeq NM_053187.3) Cal ENSMUST00000020008.1 ENSMUST00000020008.2 ENSMUST00000020008.3 ENSMUST00000020008.4 ENSMUST00000020008.5 ENSMUST00000020008.6 ENSMUST00000020008.7 ENSMUST00000020008.8 ENSMUST00000020008.9 GOPC_MOUSE Gopc NM_053187 Q8BH60 Q8BSV4 Q920R1 Q9ET11 uc007fbf.1 uc007fbf.2 uc007fbf.3 uc007fbf.4 Plays a role in intracellular protein trafficking and degradation (PubMed:12149515). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (PubMed:15317815). May also regulate the intracellular trafficking of the ADR1B receptor (By similarity). May play a role in autophagy (PubMed:12372286). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (By similarity). Overexpression results in CFTR intracellular retention and degradation in the lysosomes (By similarity). Homooligomer (PubMed:11162552). Interacts with FZD5 (PubMed:11520064). Interacts with FZD8 (PubMed:11520064). Interacts with GRID2 and BECN1 (PubMed:12372286). Interacts with CSPG5 (PubMed:12885772). Interacts with CLCN3 (PubMed:12471024). Interacts with STX6 (By similarity). Interacts with CFTR (PubMed:12471024). Interacts with ASIC3 (PubMed:15317815). Interacts with GOLGA3 (By similarity). Interacts with NLGN1 (By similarity). Interacts with RHOQ (PubMed:11162552). Interacts with MARCHF2; the interaction leads to CFTR ubiquitination and degradation (By similarity). May interact with CACNG2 (PubMed:15136571). Interacts with CCDC62 (PubMed:28339613). Q8BH60; O88597: Becn1; NbExp=5; IntAct=EBI-296357, EBI-643716; Q8BH60; Q9EQD0: Fzd5; NbExp=3; IntAct=EBI-296357, EBI-7938232; Q8BH60; Q61091: Fzd8; NbExp=3; IntAct=EBI-296357, EBI-6171689; Q8BH60; Q61625: Grid2; NbExp=5; IntAct=EBI-296357, EBI-2794106; Q8BH60; O95196: CSPG5; Xeno; NbExp=3; IntAct=EBI-296357, EBI-296349; Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Synapse. Postsynaptic density. Cell projection, dendrite. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=NPIST, Beta; IsoId=Q8BH60-1; Sequence=Displayed; Name=2; Synonyms=Alpha; IsoId=Q8BH60-2; Sequence=VSP_016065; Ubiquitously expressed (at protein level). Expressed in dorsal root glanglion (DRG), spinal cord and brain. Isoform 1 is preferentially expressed in whole brain (at protein level) and cerebellum. Expressed in spermatocytes and spermatides but not in Sertoli cells and spermatogonia. In the cerebellum, expression increases post- natally, following maturation of this tissue (at protein level). The coiled-coil region probably mediates targeting to the Golgi, oligomerization and interaction with RHOQ. May also mediates association to membranes and interactions with GOLGA3 and STX6 (By similarity). The PDZ domain mediates interaction with ADRB1 (By similarity). Mediates also interactions with FZD5, FZD8, ASIC3, GRID2, CFTR, CLCN3. Male mice are infertile with globozoospermia. Spermatozoa display a default in acrosome formation and are unable to activate oocytes. Golgi membrane frizzled binding protein binding cytoplasm Golgi apparatus plasma membrane autophagy spermatid nucleus differentiation protein C-terminus binding negative regulation of anion channel activity postsynaptic density protein transport membrane syntaxin binding cell junction trans-Golgi network transport vesicle dendrite GTPase regulator activity macromolecular complex protein homodimerization activity cell projection cytoplasmic sequestering of CFTR protein ion channel binding synapse postsynaptic membrane regulation of catalytic activity protein homooligomerization negative regulation of protein localization to cell surface uc007fbf.1 uc007fbf.2 uc007fbf.3 uc007fbf.4 
ENSMUST00000020012.7 Qrsl1 ENSMUST00000020012.7 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 (from RefSeq NM_001081054.2) ENSMUST00000020012.1 ENSMUST00000020012.2 ENSMUST00000020012.3 ENSMUST00000020012.4 ENSMUST00000020012.5 ENSMUST00000020012.6 GATA_MOUSE NM_001081054 Q3TDF6 Q6NS53 Q9CZN8 uc007ezn.1 uc007ezn.2 uc007ezn.3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate; Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216; EC=6.3.5.7; Evidence=; Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. Mitochondrion Belongs to the amidase family. GatA subfamily. nucleotide binding amidase activity ATP binding mitochondrion translation ligase activity carbon-nitrogen ligase activity, with glutamine as amido-N-donor glutamyl-tRNA(Gln) amidotransferase complex regulation of protein stability mitochondrial translation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity glutaminyl-tRNAGln biosynthesis via transamidation uc007ezn.1 uc007ezn.2 uc007ezn.3 
ENSMUST00000020015.10 Nmbr ENSMUST00000020015.10 neuromedin B receptor (from RefSeq NM_008703.3) ENSMUST00000020015.1 ENSMUST00000020015.2 ENSMUST00000020015.3 ENSMUST00000020015.4 ENSMUST00000020015.5 ENSMUST00000020015.6 ENSMUST00000020015.7 ENSMUST00000020015.8 ENSMUST00000020015.9 NM_008703 Nmbr Q0VEH1 Q0VEH1_MOUSE uc007elp.1 uc007elp.2 uc007elp.3 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity bombesin receptor activity cytosol plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane bombesin receptor signaling pathway uc007elp.1 uc007elp.2 uc007elp.3 
ENSMUST00000020016.5 Gje1 ENSMUST00000020016.5 gap junction protein, epsilon 1, transcript variant 6 (from RefSeq NR_175972.1) CXE1_MOUSE Cx23 ENSMUST00000020016.1 ENSMUST00000020016.2 ENSMUST00000020016.3 ENSMUST00000020016.4 Gje1 Gjf1 NR_175972 Q9CX92 uc007elo.1 uc007elo.2 uc007elo.3 Mediates calcium-independent ATP release, suggesting activity as a hemichannel (PubMed:18849090). Does not form functional gap junctions (PubMed:18849090). May play a non-essential role in eye lens development (PubMed:18385072, PubMed:27038752). A connexon is composed of a hexamer of connexins. Cell membrane ; Multi-pass membrane protein Highly expressed in lens, where it is mainly found in lens fibers and to a lesser extent in lens epithelium (PubMed:18385072, PubMed:18849090). Weakly expressed in retina (PubMed:18849090). Not detected in other tissues tested (PubMed:18385072, PubMed:18849090). Expressed at the posterior region of the lens vesicle at embryonic stage 11.5 dpc. Detected at the tip of elongating lens fiber cells at stage 12.5 dpc. Expressed in lens epithelial cells, and weakly in retina, at stage 15.5 dpc. No visible phenotype. Eye morphology appears to be normal with no significant effects on lens transparency and refraction. Expression levels of the connexins Cx46 and Cx50 in lens tissue are slightly reduced. Belongs to the connexin family. Beta-type (group I) subfamily. cell morphogenesis lens development in camera-type eye molecular_function cellular_component plasma membrane connexin complex cell communication multicellular organism development membrane integral component of membrane organ growth uc007elo.1 uc007elo.2 uc007elo.3 
ENSMUST00000020022.8 Smpdl3a ENSMUST00000020022.8 sphingomyelin phosphodiesterase, acid-like 3A (from RefSeq NM_020561.2) ASM3A_MOUSE Asml3a ENSMUST00000020022.1 ENSMUST00000020022.2 ENSMUST00000020022.3 ENSMUST00000020022.4 ENSMUST00000020022.5 ENSMUST00000020022.6 ENSMUST00000020022.7 NM_020561 P70158 Q3U8C2 uc007fcu.1 uc007fcu.2 uc007fcu.3 Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:26792860). Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) per subunit. ; Requires micromolar levels of Zn(2+) for activity. Inhibited by millimolar levels of Zn(2+). Kinetic parameters: KM=107 uM for ATP at pH 5 ; KM=330 uM for ATP at pH 7.5 ; Secreted Detected in blood serum (at protein level). N-glycosylated. Belongs to the acid sphingomyelinase family. extracellular region extracellular space phosphoric diester hydrolase activity biological_process zinc ion binding nucleoside triphosphate catabolic process hydrolase activity metal ion binding sphingomyelin phosphodiesterase activity sphingomyelin catabolic process uc007fcu.1 uc007fcu.2 uc007fcu.3 
ENSMUST00000020023.9 Reep3 ENSMUST00000020023.9 receptor accessory protein 3, transcript variant 2 (from RefSeq NM_178606.5) D10Ucla1 ENSMUST00000020023.1 ENSMUST00000020023.2 ENSMUST00000020023.3 ENSMUST00000020023.4 ENSMUST00000020023.5 ENSMUST00000020023.6 ENSMUST00000020023.7 ENSMUST00000020023.8 NM_178606 Q99KK1 Q9CZM8 Q9D8G3 REEP3_MOUSE uc007flq.1 uc007flq.2 uc007flq.3 uc007flq.4 Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the DP1 family. Sequence=BAB25434.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; molecular_function cellular_component endoplasmic reticulum endoplasmic reticulum membrane microtubule nuclear envelope organization cell cycle mitotic nuclear envelope reassembly membrane integral component of membrane cell division uc007flq.1 uc007flq.2 uc007flq.3 uc007flq.4 
ENSMUST00000020024.12 Fabp7 ENSMUST00000020024.12 fatty acid binding protein 7, brain (from RefSeq NM_021272.3) Blbp ENSMUST00000020024.1 ENSMUST00000020024.10 ENSMUST00000020024.11 ENSMUST00000020024.2 ENSMUST00000020024.3 ENSMUST00000020024.4 ENSMUST00000020024.5 ENSMUST00000020024.6 ENSMUST00000020024.7 ENSMUST00000020024.8 ENSMUST00000020024.9 FABP7_MOUSE NM_021272 P51880 Q4FJK4 uc007fct.1 uc007fct.2 uc007fct.3 B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers. Cytoplasm. Expressed in brain and other neural tissues. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. startle response fatty acid binding nucleus cytoplasm cytosol cell-cell junction lipid binding cell proliferation in forebrain neurogenesis cell projection neuronal cell body cell body epithelial cell proliferation prepulse inhibition cell periphery uc007fct.1 uc007fct.2 uc007fct.3 
ENSMUST00000020027.11 Serinc1 ENSMUST00000020027.11 serine incorporator 1 (from RefSeq NM_019760.4) Aigp2 ENSMUST00000020027.1 ENSMUST00000020027.10 ENSMUST00000020027.2 ENSMUST00000020027.3 ENSMUST00000020027.4 ENSMUST00000020027.5 ENSMUST00000020027.6 ENSMUST00000020027.7 ENSMUST00000020027.8 ENSMUST00000020027.9 NM_019760 Q3UZ93 Q9QZI8 SERC1_MOUSE Tde1l Tde2 Tms2 uc007fcm.1 uc007fcm.2 uc007fcm.3 uc007fcm.4 uc007fcm.5 uc007fcm.6 Enhances the incorporation of serine into phosphatidylserine and sphingolipids. Interacts with SPTLC1. Endoplasmic reticulum membrane ; Multi-pass membrane protein Highly expressed in the neuronal populations such as Purkinje cells in the cerebellum, brainstem and spinal motor neurons, locus coeruleus and raphe nuclei. Belongs to the TDE1 family. endoplasmic reticulum endoplasmic reticulum membrane plasma membrane lipid metabolic process phosphatidylserine metabolic process sphingolipid metabolic process phospholipid biosynthetic process membrane integral component of membrane enzyme binding protein binding, bridging membrane biogenesis positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity positive regulation of serine C-palmitoyltransferase activity uc007fcm.1 uc007fcm.2 uc007fcm.3 uc007fcm.4 uc007fcm.5 uc007fcm.6 
ENSMUST00000020040.5 Nts ENSMUST00000020040.5 neurotensin (from RefSeq NM_024435.2) ENSMUST00000020040.1 ENSMUST00000020040.2 ENSMUST00000020040.3 ENSMUST00000020040.4 NEUT_MOUSE NM_024435 Q9D3P9 uc007gye.1 uc007gye.2 uc007gye.3 Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle (By similarity). Interacts with NTSR1. Interacts with SORT1. Interacts with SORL1. Secreted Cytoplasmic vesicle, secretory vesicle Note=Packaged within secretory vesicles. [Neurotensin]: Neurotensin is cleaved and degraded by Angiotensin- converting enzyme (ACE) and neprilysin (MME). Belongs to the neurotensin family. neuropeptide hormone activity extracellular region signal transduction visual learning transport vesicle cytoplasmic vesicle killing of cells of other organism neuronal cell body axon terminus uc007gye.1 uc007gye.2 uc007gye.3 
ENSMUST00000020045.10 Ros1 ENSMUST00000020045.10 Ros1 proto-oncogene (from RefSeq NM_011282.2) ENSMUST00000020045.1 ENSMUST00000020045.2 ENSMUST00000020045.3 ENSMUST00000020045.4 ENSMUST00000020045.5 ENSMUST00000020045.6 ENSMUST00000020045.7 ENSMUST00000020045.8 ENSMUST00000020045.9 NM_011282 Q60705 Q78DX7 ROS1_MOUSE Ros Ros-1 uc007fbb.1 uc007fbb.2 Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (PubMed:32499443). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1, and PLCG2. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Inhibited by dephosphorylation by PTPN6. Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway. Interacts with VAV3; constitutive interaction mediating VAV3 phosphorylation (By similarity). Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation. Cell membrane ; Single-pass type I membrane protein Expressed by epithelial cells of the caput epididymis (at protein level). Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2267 and/or Tyr-2327 recruits PTPN11 (By similarity). Phosphorylation at Tyr-2267 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation (PubMed:11266449). Phosphorylation at Tyr-2267 stimulates the kinase activity and the activation of the ERK1 signaling cascade (PubMed:11266449). Mice are viable and healthy. Females display normal fertility while males are sterile due a non-cell autonomous defect in sperm maturation. It is associated with the absence of tall columnar epithelial cells with long microvilli in the proximal part of the caput epididymidis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. nucleotide binding regulation of cell growth columnar/cuboidal epithelial cell development protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway spermatogenesis cell proliferation cell surface negative regulation of gene expression regulation of phosphate transport membrane integral component of membrane kinase activity phosphorylation transferase activity protein phosphatase binding signal transduction by protein phosphorylation cell differentiation regulation of TOR signaling peptidyl-tyrosine autophosphorylation receptor complex perinuclear region of cytoplasm regulation of ERK1 and ERK2 cascade uc007fbb.1 uc007fbb.2 
ENSMUST00000020049.9 Ccdc59 ENSMUST00000020049.9 coiled-coil domain containing 59 (from RefSeq NM_025602.3) D10Ertd718e ENSMUST00000020049.1 ENSMUST00000020049.2 ENSMUST00000020049.3 ENSMUST00000020049.4 ENSMUST00000020049.5 ENSMUST00000020049.6 ENSMUST00000020049.7 ENSMUST00000020049.8 NM_025602 Q8BZ86 Q8R2N0 Q9CR69 Q9CV91 TAP26_MOUSE Tap26 uc007gyp.1 uc007gyp.2 uc007gyp.3 Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities (By similarity). Interacts with NKX2-1. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R2N0-1; Sequence=Displayed; Name=2; IsoId=Q8R2N0-2; Sequence=VSP_027489, VSP_027490; Belongs to the TAP26 family. nucleus uc007gyp.1 uc007gyp.2 uc007gyp.3 
ENSMUST00000020057.16 Lin7a ENSMUST00000020057.16 lin-7 homolog A, crumbs cell polarity complex component, transcript variant 1 (from RefSeq NM_001039354.2) ENSMUST00000020057.1 ENSMUST00000020057.10 ENSMUST00000020057.11 ENSMUST00000020057.12 ENSMUST00000020057.13 ENSMUST00000020057.14 ENSMUST00000020057.15 ENSMUST00000020057.2 ENSMUST00000020057.3 ENSMUST00000020057.4 ENSMUST00000020057.5 ENSMUST00000020057.6 ENSMUST00000020057.7 ENSMUST00000020057.8 ENSMUST00000020057.9 LIN7A_MOUSE Mals1 NM_001039354 Q8JZS0 Veli1 uc007gyy.1 uc007gyy.2 uc007gyy.3 Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Forms a complex with CASK and CASKIN1 (By similarity). Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2- LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (PubMed:10846156). Can also interact with other modular proteins containing protein-protein interaction domains like PALS1, PALS2, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4, GRIN2B and MARCHF11 as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta- catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C) (By similarity). Cell membrane ; Peripheral membrane protein Basolateral cell membrane ; Peripheral membrane protein Cell junction Postsynaptic density membrane ; Peripheral membrane protein Cell junction, tight junction Note=Mainly basolateral in renal epithelial cells. Expressed in the kidney, along the length of the nephron. The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane. The PDZ domain regulates endocytosis and recycling of the receptor at the membrane. The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes. Belongs to the lin-7 family. protein binding plasma membrane cell-cell junction bicellular tight junction exocytosis neurotransmitter secretion postsynaptic density protein transport membrane basolateral plasma membrane cell junction neuron projection maintenance of epithelial cell apical/basal polarity synapse postsynaptic membrane synaptic vesicle transport inner ear development L27 domain binding MPP7-DLG1-LIN7 complex presynapse protein localization to basolateral plasma membrane uc007gyy.1 uc007gyy.2 uc007gyy.3 
ENSMUST00000020062.4 Gprc6a ENSMUST00000020062.4 G protein-coupled receptor, family C, group 6, member A (from RefSeq NM_153071.1) ENSMUST00000020062.1 ENSMUST00000020062.2 ENSMUST00000020062.3 GPC6A_MOUSE NM_153071 Q5DK51 Q5DK52 Q8K4Z6 uc007fau.1 uc007fau.2 Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations (PubMed:15576628, PubMed:16199532, PubMed:21333348). Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids (PubMed:15576628). The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+) (PubMed:16199532). Seems to act through a G(q)/G(11) and G(i)-coupled pathway (PubMed:15576628, PubMed:16199532). Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (PubMed:21333348). Mediates the non-genomic effects of androgens in multiple tissue (PubMed:19050760). May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (PubMed:19050760, PubMed:20947496). Homodimer; disulfide-linked. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K4Z6-1; Sequence=Displayed; Name=2; IsoId=Q8K4Z6-2; Sequence=VSP_016456; Name=3; IsoId=Q8K4Z6-3; Sequence=VSP_016457; Expressed at high level in liver, lung, spleen and heart. Expressed at lower level in kidney, skeletal muscle and brain. Expressed in 7 dpc, 11 dpc, 15 dpc and 17 dpc embryos. N-glycosylated. Deficient mice shown normal body weight, an increased fat mass, decreased lean body, hyperglycemia and insulin resistance, proteinuria, renal calcium, phosphate wasting, impaired bone mineral density and defective testicular function (PubMed:19050760, PubMed:20947496). Conditional deletion in Leydig cells leads to decreased male fertility (PubMed:21333348). Belongs to the G-protein coupled receptor 3 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway cell surface membrane integral component of membrane calcium-mediated signaling signaling receptor activity response to amino acid uc007fau.1 uc007fau.2 
ENSMUST00000020064.5 Fam162b ENSMUST00000020064.5 family with sequence similarity 162, member B (from RefSeq NM_029894.1) ENSMUST00000020064.1 ENSMUST00000020064.2 ENSMUST00000020064.3 ENSMUST00000020064.4 F162B_MOUSE NM_029894 Q9CX19 uc007fat.1 uc007fat.2 uc007fat.3 uc007fat.4 Membrane ; Single-pass membrane protein Belongs to the UPF0389 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007fat.1 uc007fat.2 uc007fat.3 uc007fat.4 
ENSMUST00000020071.4 Sim1 ENSMUST00000020071.4 single-minded family bHLH transcription factor 1 (from RefSeq NM_011376.3) ENSMUST00000020071.1 ENSMUST00000020071.2 ENSMUST00000020071.3 NM_011376 O70284 P70183 Q61045 SIM1_MOUSE uc007fal.1 uc007fal.2 Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer; forms a heterodimer with ARNT, ARNT2. Q61045; P53762: Arnt; NbExp=4; IntAct=EBI-78890, EBI-78852; Nucleus Detected in lung, skeletal muscle and kidney. During fetal development it is found in the CNS, developing kidney, mesodermal and endodermal tissues, including developing somites, mesonephric duct, and foregut. Sequence=AAA91201.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; RNA polymerase II transcription factor activity, sequence-specific DNA binding ureteric bud development DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development nervous system development cell differentiation positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity uc007fal.1 uc007fal.2 
ENSMUST00000020081.11 Zwint ENSMUST00000020081.11 ZW10 interactor, transcript variant 2 (from RefSeq NM_001293683.1) D10Ertd749e ENSMUST00000020081.1 ENSMUST00000020081.10 ENSMUST00000020081.2 ENSMUST00000020081.3 ENSMUST00000020081.4 ENSMUST00000020081.5 ENSMUST00000020081.6 ENSMUST00000020081.7 ENSMUST00000020081.8 ENSMUST00000020081.9 NM_001293683 Q3UYT8 Q91VI4 Q9CQU5 Q9D0W9 ZWINT_MOUSE uc007fpa.1 uc007fpa.2 uc007fpa.3 uc007fpa.4 Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity). Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with KNL1, CETN3, DSN1 and PMF1 (By similarity). Nucleus Chromosome, centromere, kinetochore Note=Localizes to kinetochores from late prophase to anaphase. mitotic sister chromatid segregation chromosome, centromeric region kinetochore condensed chromosome kinetochore protein binding nucleus nucleoplasm chromosome cytoplasm cytosol cell cycle mitotic cell cycle checkpoint nuclear body dendrite neuron projection intracellular membrane-bounded organelle protein N-terminus binding cell division establishment of localization in cell uc007fpa.1 uc007fpa.2 uc007fpa.3 uc007fpa.4 
ENSMUST00000020085.7 Ube2d1 ENSMUST00000020085.7 ubiquitin-conjugating enzyme E2D 1, transcript variant 6 (from RefSeq NR_185290.1) ENSMUST00000020085.1 ENSMUST00000020085.2 ENSMUST00000020085.3 ENSMUST00000020085.4 ENSMUST00000020085.5 ENSMUST00000020085.6 NR_185290 Q3UFQ4 Q3UFQ4_MOUSE Ube2d1 uc007foo.1 uc007foo.2 uc007foo.3 Belongs to the ubiquitin-conjugating enzyme family. ubiquitin ligase complex nucleotide binding protein polyubiquitination ubiquitin-protein transferase activity ATP binding cytoplasm ubiquitin-dependent protein catabolic process transferase activity positive regulation of protein ubiquitination macromolecular complex ubiquitin conjugating enzyme activity protein K48-linked ubiquitination uc007foo.1 uc007foo.2 uc007foo.3 
ENSMUST00000020090.8 Mrln ENSMUST00000020090.8 myoregulin (from RefSeq NM_001304739.1) ENSMUST00000020090.1 ENSMUST00000020090.2 ENSMUST00000020090.3 ENSMUST00000020090.4 ENSMUST00000020090.5 ENSMUST00000020090.6 ENSMUST00000020090.7 MLN_MOUSE Mln Mrln NM_001304739 Q9CV60 uc007fnp.1 uc007fnp.2 uc007fnp.3 uc007fnp.4 uc007fnp.5 uc007fnp.6 This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. [provided by RefSeq, Feb 2015]. ##Evidence-Data-START## Transcript exon combination :: BX523793.1, AK009351.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. Interacts with ATP2A1/SERCA1. Sarcoplasmic reticulum membrane ; Single-pass membrane protein Specifically expressed in all skeletal muscles. Not expressed in cardiac or smooth muscles. During embryogenesis, expressed in the myotomal compartment of the somites and the anlagen of skeletal muscle. During fetal and adult stages, strongly expressed in all skeletal muscles. Not detectable in cardiac or smooth muscles. Expression is regulated by MYEF2 and MYOD1. Mice were born at expected Mendelian ratios and did not show no obvious morphological abnormalities or differences in body or muscle weights. They however show enhanced Ca(2+) handling in skeletal muscle and improved exercise performance. Sequence=BAB26234.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=EDL31981.1; Type=Erroneous gene model prediction; Evidence=; enzyme inhibitor activity protein binding endoplasmic reticulum membrane response to wounding membrane integral component of membrane sarcoplasmic reticulum sarcoplasmic reticulum membrane negative regulation of catalytic activity negative regulation of calcium ion binding negative regulation of calcium-transporting ATPase activity negative regulation of calcium ion import into sarcoplasmic reticulum uc007fnp.1 uc007fnp.2 uc007fnp.3 uc007fnp.4 uc007fnp.5 uc007fnp.6 
ENSMUST00000020094.8 Epyc ENSMUST00000020094.8 epiphycan, transcript variant 1 (from RefSeq NM_007884.2) Dspg3 ENSMUST00000020094.1 ENSMUST00000020094.2 ENSMUST00000020094.3 ENSMUST00000020094.4 ENSMUST00000020094.5 ENSMUST00000020094.6 ENSMUST00000020094.7 EPYC_MOUSE NM_007884 P70186 Pglb uc007gxb.1 uc007gxb.2 May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization. Secreted, extracellular space, extracellular matrix. Note=Surrounding resting, proliferating, and hypertrophic chondrocytes. Confined to the middle zone of embryonic epiphyseal cartilage consisting of flattened chondrocytes and the ossifying region in the limb buds of chick embryos. Has also been detected in testis. Expression starts at 12.5 dpc and is restricted to developing cartilage. The O-linked polysaccharide on Ser-96 is probably the mucin type linked to GalNAc. There is one glycosaminoglycan chain, known to be dermatan sulfate, and it is probably the O-glycosylation at Ser-64. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. extracellular region sensory perception of sound extracellular matrix bone development uc007gxb.1 uc007gxb.2 
ENSMUST00000020099.13 Cdk1 ENSMUST00000020099.13 cyclin dependent kinase 1 (from RefSeq NM_007659.4) CDK1_MOUSE Cdc2 Cdc2a Cdkn1 ENSMUST00000020099.1 ENSMUST00000020099.10 ENSMUST00000020099.11 ENSMUST00000020099.12 ENSMUST00000020099.2 ENSMUST00000020099.3 ENSMUST00000020099.4 ENSMUST00000020099.5 ENSMUST00000020099.6 ENSMUST00000020099.7 ENSMUST00000020099.8 ENSMUST00000020099.9 NM_007659 P11440 P70337 Q3TI12 uc007fmr.1 uc007fmr.2 uc007fmr.3 Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16007079, PubMed:17700700, PubMed:17942597, PubMed:22405274). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS, ZAR1 and RUNX2 (PubMed:17942597, PubMed:22405274, PubMed:36264786). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (By similarity). Essential for early stages of embryonic development (By similarity). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:16007079, PubMed:17700700). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1- mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (By similarity). Phosphorylates KRT5 during prometaphase and metaphase (PubMed:29518391). Inactivated by PKR/EIF2AK2- and WEE1- mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (By similarity). Reactivated after successful DNA repair through WIP1- dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (By similarity). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (By similarity). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (By similarity). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (By similarity). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (By similarity). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (By similarity). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (By similarity). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (By similarity). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (By similarity). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (By similarity). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)- mediated ubiquitination and proteasomal degradation of NR1D1 (By similarity). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (By similarity). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=; Reaction=[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho- [DNA-directed RNA polymerase]; Xref=Rhea:RHEA:10216, Rhea:RHEA- COMP:11321, Rhea:RHEA-COMP:11322, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.23; Evidence=; Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it. Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cyclins-B (CCNB1, CCNB2 and CCNB3) to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Can also form CDK1-cylin-D and CDK1-cyclin-E complexes that phosphorylate RB1 in vitro. Binds to RB1 and other transcription factors such as FOXO1 and RUNX2. Promotes G2-M transition when in complex with a cyclin-B. Interacts with DLGAP5. Binds to the CDK inhibitors CDKN1A/p21 and CDKN1B/p27. Isoform 2 is unable to complex with cyclin-B1 and also fails to bind to CDKN1A/p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase. Associates with cyclins- A and B1 during S-phase in regenerating hepatocytes. Interacts with FANCC. Interacts with CEP63; this interaction recruits CDK1 to centrosomes. Interacts with CENPA (By similarity). Interacts with NR1D1 (By similarity). Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis (PubMed:31437213). P11440; P51943: Ccna2; NbExp=2; IntAct=EBI-846949, EBI-846980; P11440; Q61457: Ccne1; NbExp=3; IntAct=EBI-846949, EBI-643090; P11440; P20263: Pou5f1; NbExp=4; IntAct=EBI-846949, EBI-1606219; Nucleus Cytoplasm Mitochondrion Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Note=Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle (By similarity). Cytoplasmic during the interphase. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2- arrested cells upon DNA-damage. Follow a cyclic expression; during interphase, accumulates gradually following G1, S to reach a critical threshold at the end of G2, which promotes self-activation and triggers onset of mitosis. Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis (Probable). Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity. Phosphorylation at Thr-14 and Tyr-15 by PKMYT1 prevents nuclear translocation. Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylation by PKMYT1 and WEE1 takes place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2. By the end of G2, PKMYT1 and WEE1 are inactivated, but CDC25A and CDC25B are activated. Dephosphorylation by active CDC25A and CDC25B at Thr-14 and Tyr-15, leads to CDK1 activation at the G2-M transition. Phosphorylation at Tyr-15 by WEE2 during oogenesis is required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, leading to prevent meiotic reentry. Phosphorylation by WEE2 is also required for metaphase II exit during egg activation to ensure exit from meiosis in oocytes and promote pronuclear formation. Phosphorylated at Tyr-4 by PKR/EIF2AK2 upon genotoxic stress. This phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest (By similarity). In response to UV irradiation, phosphorylation at Tyr-15 by PRKCD activates the G2/M DNA damage checkpoint. Polyubiquitinated upon genotoxic stress. Embryonic lethality in the first cell divisions. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding mitotic cell cycle cyclin-dependent protein kinase holoenzyme complex chromatin binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial matrix centrosome microtubule organizing center spindle cytosol cytoskeleton spindle microtubule protein phosphorylation apoptotic process cell cycle mitotic G2 DNA damage checkpoint cell aging cell proliferation RNA polymerase II carboxy-terminal domain kinase activity response to toxic substance response to organonitrogen compound positive regulation of gene expression positive regulation of G2/M transition of mitotic cell cycle response to organic cyclic compound response to amine response to activity kinase activity phosphorylation histone phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation chromosome condensation cyclin binding midbody Hsp70 protein binding epithelial cell differentiation animal organ regeneration protein localization to kinetochore histone kinase activity response to drug response to hydrogen peroxide regulation of circadian rhythm negative regulation of apoptotic process mitotic cell cycle phase transition response to ethanol positive regulation of DNA replication positive regulation of mitotic cell cycle response to cadmium ion response to copper ion rhythmic process response to axon injury cell division ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation macromolecular complex assembly cellular response to hydrogen peroxide mitotic spindle Golgi disassembly cyclin B1-CDK1 complex cyclin-dependent protein kinase activity positive regulation of protein localization to nucleus positive regulation of mitochondrial ATP synthesis coupled electron transport uc007fmr.1 uc007fmr.2 uc007fmr.3 
ENSMUST00000020102.14 Slc17a8 ENSMUST00000020102.14 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8, transcript variant 1 (from RefSeq NM_182959.3) ENSMUST00000020102.1 ENSMUST00000020102.10 ENSMUST00000020102.11 ENSMUST00000020102.12 ENSMUST00000020102.13 ENSMUST00000020102.2 ENSMUST00000020102.3 ENSMUST00000020102.4 ENSMUST00000020102.5 ENSMUST00000020102.6 ENSMUST00000020102.7 ENSMUST00000020102.8 ENSMUST00000020102.9 NM_182959 Q8BFU8 Slc17a8 VGLU3_MOUSE Vglut3 uc007gsk.1 uc007gsk.2 uc007gsk.3 uc007gsk.4 Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, sodium and phosphate (PubMed:18215623, PubMed:18080752, PubMed:12384506). At the synaptic vesicle membrane, mainly functions as an uniporter that mediates the uptake of L-glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:18215623, PubMed:18080752, PubMed:12384506). The L-glutamate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:12384506). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (By similarity). The symporter activity is electrogenic (By similarity). Moreover, operates synergistically with SLC18A3/VACHT under a constant H(+) gradient, thereby allowing striatal vesicular acetylcholine uptake (PubMed:18278042). Reaction=L-glutamate(out) = L-glutamate(in); Xref=Rhea:RHEA:66336, ChEBI:CHEBI:29985; Evidence= Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in); Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; Evidence=; Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; The L-glutamate uniporter activity exhibits a biphasic dependence on chloride concentration. Chloride channel activity is allosterically activated by lumenal H(+) and Cl(-) leading to synaptic vesicles acidification. The L-glutamate transport activity is allosterically activated by lumenal H(+) and Cl(-), preventing non- vesicular L-glutamate release. Kinetic parameters: KM=1.3 mM for L-glutamate ; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Cell membrane ; Multi-pass membrane protein Synapse, synaptosome Expressed in restricted areas of the brain. Highest expression is found in the neurons of the basal forebrain, the hippocampal formation, and the majority of the neurons of the mesencephalic raphe nuclei. Expressed in inner hair cells of the ear. Expression peaks at P7 in the brain. Expressed in inner hair cells from 19 dpc onwards. Mice are hyperactive and suffer from intermittent, spontaneous cortical seizures. They exhibit reduced cholinergic transmission in the ventral portion of the striatum and defective acetylcholine release. They are hypersensitive to cocaine and less prone to haloperidol-induced catalepsy. Mice defective in Slc17a8 are profoundly deaf owing to the absence of glutamate release from hair cells at the first synapse in the auditory pathway. They lack auditory-nerve responses to acoustic stimuli, although auditory brainstem responses could be elicited by electrical stimuli. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. neural retina development L-glutamate transmembrane transporter activity neurotransmitter transporter activity cytoplasm multivesicular body integral component of plasma membrane ion transport sodium ion transport neurotransmitter transport brain development sensory perception of sound symporter activity L-glutamate transport membrane integral component of membrane cell junction integral component of synaptic vesicle membrane dendrite synaptic vesicle membrane cytoplasmic vesicle synaptic transmission, glutamatergic neuron projection neuronal cell body perikaryon axon terminus synapse regulation of synapse structure or activity transmembrane transport excitatory synapse cochlea development apical dendrite basilar dendrite glial limiting end-foot neurotransmitter loading into synaptic vesicle pericellular basket uc007gsk.1 uc007gsk.2 uc007gsk.3 uc007gsk.4 
ENSMUST00000020107.8 Atp2b1 ENSMUST00000020107.8 ATPase, Ca++ transporting, plasma membrane 1, transcript variant 2 (from RefSeq NM_026482.2) AT2B1_MOUSE Atp2b1 ENSMUST00000020107.1 ENSMUST00000020107.2 ENSMUST00000020107.3 ENSMUST00000020107.4 ENSMUST00000020107.5 ENSMUST00000020107.6 ENSMUST00000020107.7 G5E829 NM_026482 uc007gxf.1 uc007gxf.2 uc007gxf.3 Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:22311909, PubMed:16956963, PubMed:28827723, PubMed:26392310, PubMed:29950683, PubMed:24805951, PubMed:23266958). Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction (PubMed:24805951, PubMed:29950683, PubMed:22311909). Positively regulates bone mineralization through absorption of calcium from the intestine (PubMed:23266958, PubMed:26392310). Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (PubMed:23266958). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles. Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.10; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18106; Evidence=; Monomer. Dimer. Oligomer. Calmodulin binding. Interacts with PDZD11. Interacts with SLC35G1 and STIM1. Interacts with YWHAE; interacts with the monomeric and dimeric forms of the YWHAE but prefer the monomer form; this interaction inhibits calcium-transporting ATPase activity (By similarity). Interacts with NPTN; this interaction stabilizes ATP2B1 and increases ATPase activity; this interaction controls T cell calcium homeostasis following T cell activation (PubMed:28827723). Interacts with EPB41; regulates small intestinal calcium absorption through regulation of membrane expression of ATP2B1 (PubMed:23460639). Cell membrane ; Multi-pass membrane protein Basolateral cell membrane Synapse Presynaptic cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Note=Colocalizes with SV2A in photoreceptor synaptic terminals (PubMed:12209837). Colocalizes with NPTN to the immunological synapse (PubMed:28827723). Colocalizes with EPB41 to the basolateral membrane in enterocyte (PubMed:23460639). Preferentially sorted to recycling synaptic vesicles. Expressed in the retina, with strongest expression in the outer plexiform layer and lower expression levels in the inner nuclear layer and the inner plexiform layer (PubMed:12209837). Specifically expressed in the following retinal cell types: photoreceptor cells, cone bipolar cells and horizontal cells (PubMed:12209837). Expressed in osteoclasts (at protein level) (PubMed:23266958). Expressed at highest levels in brain, intestine, kidney, and stomach, and at lower levels in liver, lung, aorta, portal vein, urinary bladder, diaphragm, seminal vesicles and testes (PubMed:15178683). Expressed in small intestinal epithelium (PubMed:23460639). Up-regulated in differentiating osteoclasts. Up-regulated following T cell activation. Complete embryonic lethality (PubMed:15178683). Mice with conditional knockout of ATP2B1 in enterocytes, are born at a lower frequency and are smaller at birth and into adulthood than wild- type. At two months of age, mice have a decreased bone mineral density (PubMed:26392310). Mice with conditional knockout of ATP2B1 in vascular smooth muscle cells (VSMCs) are born at the expected Mendelian ratio and grow normaly but have a higher blood pressure than wild-type under resting conditions (PubMed:22311909). Heterozygous ATP2B1 mice are hypertensive and exhibit hypocalcemia and a higher bone mineral density (PubMed:29950683). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. nucleotide binding immunological synapse negative regulation of cytokine production regulation of vascular smooth muscle contraction neural retina development calcium-transporting ATPase activity protein binding calmodulin binding ATP binding nucleus plasma membrane integral component of plasma membrane ion transport calcium ion transport cellular calcium ion homeostasis brain development aging regulation of blood pressure response to cold cytoplasmic side of plasma membrane calcium ion transmembrane transporter activity membrane integral component of membrane basolateral plasma membrane apical plasma membrane ATPase activity cell junction PDZ domain binding positive regulation of bone mineralization dendrite membrane dendritic spine membrane neuronal cell body membrane membrane raft apical part of cell synapse metal ion binding regulation of cytosolic calcium ion concentration negative regulation of cytosolic calcium ion concentration positive regulation of calcium ion transport calcium ion transmembrane transport cellular response to vitamin D cellular response to corticosterone stimulus glutamatergic synapse GABA-ergic synapse integral component of presynaptic active zone membrane regulation of presynaptic cytosolic calcium ion concentration regulation of cellular response to insulin stimulus calcium ion export calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration calcium ion export from cell uc007gxf.1 uc007gxf.2 uc007gxf.3 
ENSMUST00000020109.5 Actr6 ENSMUST00000020109.5 ARP6 actin-related protein 6, transcript variant 1 (from RefSeq NM_025914.3) A0A0R4J009 A0A0R4J009_MOUSE Actr6 ENSMUST00000020109.1 ENSMUST00000020109.2 ENSMUST00000020109.3 ENSMUST00000020109.4 NM_025914 uc007gss.1 uc007gss.2 uc007gss.3 Belongs to the actin family. ARP6 subfamily. nucleus chromatin remodeling uc007gss.1 uc007gss.2 uc007gss.3 
ENSMUST00000020112.7 Bltp3b ENSMUST00000020112.7 bridge-like lipid transfer protein family member 3B (from RefSeq NM_029166.2) A2RSJ4 B2RQV0 BLT3B_MOUSE E9QMH4 ENSMUST00000020112.1 ENSMUST00000020112.2 ENSMUST00000020112.3 ENSMUST00000020112.4 ENSMUST00000020112.5 ENSMUST00000020112.6 Kiaa0701 NM_029166 Q8CHD4 Ship164 Uhrf1bp1l uc007gsv.1 uc007gsv.2 uc007gsv.3 uc007gsv.4 Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites. Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex. Homodimer (via N-terminus). Associates with the Golgi- associated retrograde protein (GARP) complex. Interacts with GARP complex component VPS52. Interacts (via C-terminal coiled-coil domain) with STX6. Cytoplasm, cytosol Early endosome Note=Localizes on a subpopulation of vesicle clusters in the early endocytic pathway. Sequence=BAC41445.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cytoplasm endosome early endosome cytosol biological_process protein homodimerization activity uc007gsv.1 uc007gsv.2 uc007gsv.3 uc007gsv.4 
ENSMUST00000020113.15 Poc1b ENSMUST00000020113.15 POC1 centriolar protein B, transcript variant 1 (from RefSeq NM_027740.7) ENSMUST00000020113.1 ENSMUST00000020113.10 ENSMUST00000020113.11 ENSMUST00000020113.12 ENSMUST00000020113.13 ENSMUST00000020113.14 ENSMUST00000020113.2 ENSMUST00000020113.3 ENSMUST00000020113.4 ENSMUST00000020113.5 ENSMUST00000020113.6 ENSMUST00000020113.7 ENSMUST00000020113.8 ENSMUST00000020113.9 NM_027740 POC1B_MOUSE Q8BHD1 Wdr51b uc007gxh.1 uc007gxh.2 uc007gxh.3 Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. Required for retinal integrity. Interacts with POC1A. Interacts with FAM161A. Interacts with CEP44; the interaction is direct and recruits POC1B to centriolar microtubules. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, spindle pole Note=Component of both mother and daughter centrioles. Localizes to the basal body and centriole adjacent to the connecting cilium of photoreceptors and in synapses of the outer plexiform layer. Expressed in the retina. Phosphorylated in mitotic cells that may be mediated by CDK1. Belongs to the WD repeat POC1 family. spindle pole retina homeostasis molecular_function cytoplasm centrosome centriole cytoskeleton cell proliferation cell projection organization ciliary basal body cell projection cilium assembly uc007gxh.1 uc007gxh.2 uc007gxh.3 
ENSMUST00000020118.5 Dusp6 ENSMUST00000020118.5 dual specificity phosphatase 6 (from RefSeq NM_026268.3) DUS6_MOUSE ENSMUST00000020118.1 ENSMUST00000020118.2 ENSMUST00000020118.3 ENSMUST00000020118.4 Mkp3 NM_026268 Q542I5 Q9D7L4 Q9DBB1 uc007gxk.1 uc007gxk.2 uc007gxk.3 uc007gxk.4 Inactivates MAP kinases. Has a specificity for the ERK family (By similarity). Plays an important role in alleviating acute postoperative pain (PubMed:24155322, PubMed:28405172). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (PubMed:24155322). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (PubMed:28405172). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Interacts with MAPK1/ERK2. Q9DBB1; P63085: Mapk1; NbExp=2; IntAct=EBI-7812384, EBI-397697; Cytoplasm Up-regulated in local wound tissue 5-7 days after surgical incision. Mice exhibit a persistent state of mechanical allodynia following plantar incision (PubMed:24155322, PubMed:28405172). This allodynia phenotype is concurrent with long- lasting spinal phosphorylation of MAPK1/3 and MAP kinase p38 (PubMed:24155322). Tissue at the local incision site also shows prolonged expression of phosphorylated MAPK1/3 which persists through to post-operative day 12, although levels of phosphorylated MAP kinase p38 are normal (PubMed:28405172). Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. inactivation of MAPK activity negative regulation of protein phosphorylation phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding cytoplasm cytosol protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity response to organic substance positive regulation of cell death response to organic cyclic compound dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity cell differentiation peptidyl-tyrosine dephosphorylation response to drug positive regulation of apoptotic process response to nitrosative stress regulation of heart growth negative regulation of ERK1 and ERK2 cascade response to growth factor uc007gxk.1 uc007gxk.2 uc007gxk.3 uc007gxk.4 
ENSMUST00000020123.7 Tmpo ENSMUST00000020123.7 thymopoietin, transcript variant 1 (from RefSeq NM_011605.3) B2RUB9 ENSMUST00000020123.1 ENSMUST00000020123.2 ENSMUST00000020123.3 ENSMUST00000020123.4 ENSMUST00000020123.5 ENSMUST00000020123.6 LAP2A_MOUSE Lap2 NM_011605 Q61028 Q61033 uc007gtv.1 uc007gtv.2 uc007gtv.3 uc007gtv.4 May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1 (By similarity). Homooligomer. Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages (By similarity). Interacts with CMTM6 (By similarity). Q61033-1; Q61033-1: Tmpo; NbExp=3; IntAct=EBI-15641551, EBI-15641551; Nucleus Chromosome Note=Expressed diffusely throughout the nucleus. Event=Alternative splicing; Named isoforms=6; Name=Alpha; IsoId=Q61033-1; Sequence=Displayed; Name=Zeta; IsoId=Q61033-2; Sequence=VSP_010128, VSP_010129; Name=Beta; IsoId=Q61029-1; Sequence=External; Name=Delta; IsoId=Q61029-2; Sequence=External; Name=Epsilon; IsoId=Q61029-3; Sequence=External; Name=Gamma; IsoId=Q61029-4; Sequence=External; The N-terminal part contains two structurally independent, non- interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1 (By similarity). The C-terminal domain forms a four-stranded coiled coil. Phosphorylated in a mitose-specific manner. Belongs to the LEM family. chromatin DNA binding protein binding nucleus nuclear envelope nuclear inner membrane chromosome regulation of transcription, DNA-templated nuclear membrane identical protein binding endoplasmic reticulum membrane uc007gtv.1 uc007gtv.2 uc007gtv.3 uc007gtv.4 
ENSMUST00000020145.12 Sgk1 ENSMUST00000020145.12 serum/glucocorticoid regulated kinase 1, transcript variant 6 (from RefSeq NM_011361.3) ENSMUST00000020145.1 ENSMUST00000020145.10 ENSMUST00000020145.11 ENSMUST00000020145.2 ENSMUST00000020145.3 ENSMUST00000020145.4 ENSMUST00000020145.5 ENSMUST00000020145.6 ENSMUST00000020145.7 ENSMUST00000020145.8 ENSMUST00000020145.9 NM_011361 Q3TJN4 Q3UKD0 Q3UKF2 Q3V1V1 Q6NS85 Q9WVC6 SGK1_MOUSE Sgk uc007eox.1 uc007eox.2 uc007eox.3 uc007eox.4 This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This enzyme is activated by protein phosphorylation and degraded via the ubiquitination and proteasome pathway. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 12. [provided by RefSeq, Sep 2009]. Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up- regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Two specific sites, one in the kinase domain (Thr- 256) and the other in the C-terminal regulatory region (Ser-422), need to be phosphorylated for its full activation (By similarity). Phosphorylation at Ser-397 and Ser-401 are also essential for its activity (By similarity). Activated by WNK1, WNK2, WNK3 and WNK4; which promote phosphorylation by mTORC2 (PubMed:20525693). Homodimer; disulfide-linked. Interacts with MAPK3/ERK1, MAPK1/ERK2, MAP2K1/MEK1, MAP2K2/MEK2, NEDD4, NEDD4L, MAPT/TAU, MAPK7, CREB1, SLC9A3R2/NHERF2 and KCNJ1/ROMK1 (By similarity). Forms a trimeric complex with FBXW7 and NOTCH1 Associates with the mammalian target of rapamycin complex 2 (mTORC2) via an interaction with MAPKAP1/SIN1. Q9WVC6; Q99N57: Raf1; NbExp=2; IntAct=EBI-15591730, EBI-397757; Q9WVC6; Q9Z2S7-3: Tsc22d3; NbExp=2; IntAct=EBI-15591730, EBI-15771036; Cytoplasm Nucleus Endoplasmic reticulum membrane Cell membrane Mitochondrion Note=The subcellular localization is controlled by the cell cycle, as well as by exposure to specific hormones and environmental stress stimuli. In proliferating cells, it shuttles between the nucleus and cytoplasm in synchrony with the cell cycle, and in serum/growth factor-stimulated cells it resides in the nucleus. In contrast, after exposure to environmental stress or treatment with glucocorticoids, it is detected in the cytoplasm and with certain stress conditions is associated with the mitochondria. In osmoregulation through the epithelial sodium channel, it can be localized to the cytoplasmic surface of the cell membrane. Nuclear, upon phosphorylation (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9WVC6-1; Sequence=Displayed; Name=2; IsoId=Q9WVC6-2; Sequence=VSP_037788; Name=3; IsoId=Q9WVC6-3; Sequence=VSP_037789; Up-regulated by tumor suppressor p53 in mammary epithelial tumor cells. Regulated by phosphorylation. Activated by phosphorylation on Ser- 422 by mTORC2, transforming it into a substrate for PDPK1 which phosphorylates it on Thr-256. Phosphorylation on Ser-397 and Ser-401 are also essential for its activity. Phosphorylation on Ser-78 by MAPK7 is required for growth factor-induced cell cycle progression (By similarity). Ubiquitinated by NEDD4L; which promotes proteasomal degradation. Ubiquitinated by SYVN1 at the endoplasmic reticulum; which promotes rapid proteasomal degradation and maintains a high turnover rate in resting cells (By similarity). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Sequence=AAH70401.1; Type=Erroneous initiation; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding nucleus cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane protein phosphorylation cellular sodium ion homeostasis apoptotic process cellular response to DNA damage stimulus microtubule depolymerization long-term memory visual learning positive regulation of sodium ion transport potassium channel regulator activity membrane kinase activity phosphorylation nuclear speck transferase activity peptidyl-serine phosphorylation positive regulation of cell growth negative regulation of microtubule polymerization cellular response to insulin stimulus regulation of protein localization intracellular signal transduction neuron projection negative regulation of apoptotic process glucocorticoid mediated signaling pathway 3-phosphoinositide-dependent protein kinase binding cofactor binding tau protein binding perinuclear region of cytoplasm neuron projection morphogenesis positive regulation of dendrite morphogenesis regulation of cell cycle uc007eox.1 uc007eox.2 uc007eox.3 uc007eox.4 
ENSMUST00000020149.6 Ikbip ENSMUST00000020149.6 IKBKB interacting protein, transcript variant 1 (from RefSeq NM_026166.2) E9QMH7 E9QMH7_MOUSE ENSMUST00000020149.1 ENSMUST00000020149.2 ENSMUST00000020149.3 ENSMUST00000020149.4 ENSMUST00000020149.5 Ikbip NM_026166 uc007gtl.1 uc007gtl.2 uc007gtl.3 endoplasmic reticulum uc007gtl.1 uc007gtl.2 uc007gtl.3 
ENSMUST00000020157.13 Apaf1 ENSMUST00000020157.13 apoptotic peptidase activating factor 1, transcript variant 1 (from RefSeq NM_001042558.1) A2RRK8 APAF_MOUSE ENSMUST00000020157.1 ENSMUST00000020157.10 ENSMUST00000020157.11 ENSMUST00000020157.12 ENSMUST00000020157.2 ENSMUST00000020157.3 ENSMUST00000020157.4 ENSMUST00000020157.5 ENSMUST00000020157.6 ENSMUST00000020157.7 ENSMUST00000020157.8 ENSMUST00000020157.9 NM_001042558 O88879 uc007gtg.1 uc007gtg.2 uc007gtg.3 Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). Monomer. Oligomerizes to a heptameric ring, known as the apoptosome, upon binding of cytochrome c and dATP. Oligomeric Apaf-1 and pro-caspase-9 bind to each other via their respective NH2-terminal CARD domains and consecutively mature caspase-9 is released from the complex (By similarity). Interacts with UACA. It may also interact with Bcl-XL. Interacts with APIP. Interacts (via CARD and NACHT domains) with NAIP/BIRC1 (via NACHT domain) (By similarity). Interacts with CIAO2A (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Apaf-1L; IsoId=O88879-1; Sequence=Displayed; Name=2; IsoId=O88879-2; Sequence=VSP_006763; Highly expressed in lung and spleen, weakly in brain and kidney and not detectable in liver. High levels in embryonic brain and liver from 11.5 dpc to 17.5 dpc. The CARD domain mediates interaction with APIP. The monomeric form is autoinhibited in a closed conformation through a bound ADP at the nucleotide binding site. Exchange of ADP for ATP and binding of cytochrome c trigger a large conformational change where the first WD repeat region swings out, allowing the NB-ARC domain to rotate and expose the contact areas for oligomerization. Physiological concentrations of calcium ions negatively affect the assembly of apoptosome by inhibiting nucleotide exchange in the monomeric form. [Isoform 1]: Major isoform. nucleotide binding response to hypoxia kidney development neural tube closure ATP binding nucleus cytoplasm cytosol apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process multicellular organism development brain development aging response to nutrient activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c cysteine-type endopeptidase activator activity involved in apoptotic process cardiac muscle cell apoptotic process cell differentiation forebrain development heat shock protein binding macromolecular complex identical protein binding regulation of apoptotic process apoptosome ADP binding protein homooligomerization neuron apoptotic process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to transforming growth factor beta stimulus apoptotic signaling pathway regulation of apoptotic DNA fragmentation positive regulation of apoptotic signaling pathway uc007gtg.1 uc007gtg.2 uc007gtg.3 
ENSMUST00000020158.9 Myb ENSMUST00000020158.9 myeloblastosis oncogene, transcript variant 2 (from RefSeq NM_010848.3) E9QMG8 ENSMUST00000020158.1 ENSMUST00000020158.2 ENSMUST00000020158.3 ENSMUST00000020158.4 ENSMUST00000020158.5 ENSMUST00000020158.6 ENSMUST00000020158.7 ENSMUST00000020158.8 MYB_MOUSE NM_010848 P06876 Q61929 uc007eog.1 uc007eog.2 uc007eog.3 Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. Binds to HIPK1 (By similarity). Interacts with HIPK2, MAF, MYBBP1A and NLK. P06876; Q9QZR5: Hipk2; NbExp=2; IntAct=EBI-366934, EBI-366905; P06876; P38531: HSF3; Xeno; NbExp=2; IntAct=EBI-366934, EBI-16212976; Nucleus Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression. C-terminal truncated mutants display increased transactivation. SUMOylated by TRAF7; leading to MYB transcriptional activity inhibition. Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. Phosphorylated by NLK on multiple sites, which induces proteasomal degradation. Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels (By similarity). G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter mitotic cell cycle RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytosol chromatin remodeling regulation of transcription, DNA-templated calcium ion transport regulation of gene expression stem cell division myeloid cell differentiation B cell differentiation positive regulation of T-helper cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter spleen development thymus development embryonic digestive tract development homeostasis of number of cells positive regulation of histone H3-K4 methylation positive regulation of histone H3-K9 methylation cellular response to interleukin-6 WD40-repeat domain binding cellular response to leukemia inhibitory factor uc007eog.1 uc007eog.2 uc007eog.3 
ENSMUST00000020159.15 Med23 ENSMUST00000020159.15 mediator complex subunit 23, transcript variant 2 (from RefSeq NM_027347.4) Crsp3 ENSMUST00000020159.1 ENSMUST00000020159.10 ENSMUST00000020159.11 ENSMUST00000020159.12 ENSMUST00000020159.13 ENSMUST00000020159.14 ENSMUST00000020159.2 ENSMUST00000020159.3 ENSMUST00000020159.4 ENSMUST00000020159.5 ENSMUST00000020159.6 ENSMUST00000020159.7 ENSMUST00000020159.8 ENSMUST00000020159.9 Kiaa1216 MED23_MOUSE NM_027347 Q6ZPV7 Q80YQ2 Q8CEC3 Q8K587 Q9CXY8 Sur2 uc007erf.1 uc007erf.2 uc007erf.3 uc007erf.4 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Also required for transcriptional activation subsequent to the assembly of the pre- initiation complex. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB (when not methylated), CTNNB1, and GLI3. Interacts with CDK8 and ELK1. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80YQ2-1; Sequence=Displayed; Name=2; IsoId=Q80YQ2-2; Sequence=VSP_028382; Name=3; IsoId=Q80YQ2-3; Sequence=VSP_041583, VSP_041584; [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the Mediator complex subunit 23 family. Sequence=AAM28897.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB29019.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC26001.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; Sequence=BAC98122.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; ubiquitin ligase complex nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of gene expression protein ubiquitination mediator complex positive regulation of T cell extravasation ubiquitin protein ligase activity uc007erf.1 uc007erf.2 uc007erf.3 uc007erf.4 
ENSMUST00000020161.10 Arg1 ENSMUST00000020161.10 arginase, liver (from RefSeq NM_007482.3) ARGI1_MOUSE ENSMUST00000020161.1 ENSMUST00000020161.2 ENSMUST00000020161.3 ENSMUST00000020161.4 ENSMUST00000020161.5 ENSMUST00000020161.6 ENSMUST00000020161.7 ENSMUST00000020161.8 ENSMUST00000020161.9 NM_007482 Q3TB74 Q3UEL0 Q4FK78 Q61176 Q80VI4 uc007erg.1 uc007erg.2 uc007erg.3 uc007erg.4 Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (By similarity). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (PubMed:27043409). Plays a role in the immune response of alternatively activated or M2 macrophages in processes such as wound healing and tissue regeneration, immune defense against multicellular pathogens and parasites, and immune suppression and allergic inflammation; the regulatory outcome seems to be organ specific (PubMed:7537672, PubMed:19360123, PubMed:20483789, PubMed:23552798, PubMed:23637937). In tumor-infiltrating dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) plays a role in suppression of T cell-mediated antitumor immunity (PubMed:19414774, PubMed:23248265). Reaction=H2O + L-arginine = L-ornithine + urea; Xref=Rhea:RHEA:20569, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:32682, ChEBI:CHEBI:46911; EC=3.5.3.1; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. Nitrogen metabolism; urea cycle; L-ornithine and urea from L- arginine: step 1/1. Homotrimer (By similarity). Interacts with CMTM6 (By similarity). Cytoplasm Cytoplasmic granule Expressed in macrophages (PubMed:7537672, PubMed:12193690, PubMed:19360123). Expressed in precursor and mature group 2 innate lymphoid cells (ILC2s) (PubMed:27043409). Expressed in lung tumor-associated myeloid cells (PubMed:15313928). Expressed in lung tumor-infiltrating dendritic cells (PubMed:19414774). By T helper 2 (Th2) cytokines such as IL-4, IL-13 and IL-10. In tumor-infiltrating dendritic cells by prostaglandin E2. Belongs to the arginase family. Sequence=BAE28901.1; Type=Erroneous initiation; Evidence=; urea cycle liver development positive regulation of endothelial cell proliferation adaptive immune response immune system process arginase activity extracellular space cytoplasm mitochondrial outer membrane cytosol arginine metabolic process female pregnancy aging response to wounding response to herbicide response to manganese ion response to zinc ion response to selenium ion regulation of L-arginine import response to amine hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines arginine catabolic process to ornithine manganese ion binding lung development response to lipopolysaccharide collagen biosynthetic process response to vitamin A response to vitamin E negative regulation of T cell proliferation response to drug defense response to protozoan neuron projection neuronal cell body response to amino acid response to peptide hormone innate immune response negative regulation of activated T cell proliferation response to cadmium ion metal ion binding response to steroid hormone response to axon injury response to methylmercury mammary gland involution maternal process involved in female pregnancy negative regulation of interferon-gamma-mediated signaling pathway protein homotrimerization cellular response to hydrogen peroxide positive regulation of neutrophil mediated killing of fungus cellular response to lipopolysaccharide cellular response to interleukin-4 cellular response to glucagon stimulus cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus negative regulation of T-helper 2 cell cytokine production uc007erg.1 uc007erg.2 uc007erg.3 uc007erg.4 
ENSMUST00000020163.7 Nedd1 ENSMUST00000020163.7 neural precursor cell expressed, developmentally down-regulated gene 1 (from RefSeq NM_008682.2) ENSMUST00000020163.1 ENSMUST00000020163.2 ENSMUST00000020163.3 ENSMUST00000020163.4 ENSMUST00000020163.5 ENSMUST00000020163.6 NEDD1_MOUSE NM_008682 Nedd-1 P33215 Q6NXV3 Q8BN12 Q8BN86 Q8BQL9 Q9CWK2 uc007gud.1 uc007gud.2 uc007gud.3 uc007gud.4 Required for mitosis progression. Promotes the nucleation of microtubules from the spindle (By similarity). May play an important role during the embryonic development and differentiation of the central nervous system (PubMed:1378265). Interacts with FAM29A. Interacts with HSPA1A and HSPA1B. Interacts with gamma-tubulin in a HSPA1A/B-dependent manner. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P33215-1; Sequence=Displayed; Name=2; IsoId=P33215-2; Sequence=VSP_016263, VSP_016264; Down-regulated during the development of brain. During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. [Isoform 2]: May be due to intron retention. pericentriolar material spindle pole gamma-tubulin ring complex, centrosomal cytoplasm centrosome centriole microtubule organizing center cytoskeleton microtubule depolymerization cell cycle microtubule polymerization or depolymerization ciliary basal body apical part of cell cell division regulation of establishment of protein localization protein localization to centrosome uc007gud.1 uc007gud.2 uc007gud.3 uc007gud.4 
ENSMUST00000020165.14 Pde7b ENSMUST00000020165.14 phosphodiesterase 7B, transcript variant 2 (from RefSeq NM_013875.6) A1L3T2 ENSMUST00000020165.1 ENSMUST00000020165.10 ENSMUST00000020165.11 ENSMUST00000020165.12 ENSMUST00000020165.13 ENSMUST00000020165.2 ENSMUST00000020165.3 ENSMUST00000020165.4 ENSMUST00000020165.5 ENSMUST00000020165.6 ENSMUST00000020165.7 ENSMUST00000020165.8 ENSMUST00000020165.9 NM_013875 PDE7B_MOUSE Pde7b Q9QXQ1 uc007eob.1 uc007eob.2 uc007eob.3 uc007eob.4 Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:10872825). May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain (By similarity). Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit (By similarity). Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (By similarity). ; Inhibited by dipyridamole, IBMX and SCH 51866. Insensitive to zaprinast, rolipram, and milrinone. Kinetic parameters: KM=0.1 uM for 3',5'-cyclic AMP ; Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. Highly expressed in brain. Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cAMP catabolic process signal transduction phosphoric diester hydrolase activity hydrolase activity metal ion binding uc007eob.1 uc007eob.2 uc007eob.3 uc007eob.4 
ENSMUST00000020169.9 Enpp3 ENSMUST00000020169.9 ectonucleotide pyrophosphatase/phosphodiesterase 3 (from RefSeq NM_134005.2) E9QMU8 ENPP3_MOUSE ENSMUST00000020169.1 ENSMUST00000020169.2 ENSMUST00000020169.3 ENSMUST00000020169.4 ENSMUST00000020169.5 ENSMUST00000020169.6 ENSMUST00000020169.7 ENSMUST00000020169.8 NM_134005 Q6DYE8 uc007era.1 uc007era.2 uc007era.3 Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines (PubMed:25692702). Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (PubMed:28225814). Has also alkaline phosphodiesterase activity (By similarity). Reaction=Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.; EC=3.1.4.1; Evidence=; Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- phosphate + diphosphate + H(+); Xref=Rhea:RHEA:23996, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.9; Evidence=; Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'- deoxyribonucleoside 5'-phosphate + diphosphate + H(+); Xref=Rhea:RHEA:44644, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:65317; EC=3.6.1.9; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 zinc ions per subunit. ; Monomer and homodimer. Cell membrane ; Single-pass type II membrane protein Apical cell membrane ; Single-pass type II membrane protein Secreted Note=Detected at the cell surface of basophils (PubMed:25692702). Detected at the apical plasma membrane of bile duct cells. Located to the apical surface in intestinal and kidney epithelial cells. Secreted in serum, and in lumen of epithelial cells (By similarity). Detected at the tip of villi in the small intestine (PubMed:28225814). Detected on basophils and mast cells (at protein level) (PubMed:25692702). Detected in the epithelial layer of the small intestine; expression is higher in the proximal part and lower in the distal part of the small intestine (PubMed:28225814). In bone marrow-derived mast cells and basophils, induced by activation of the high affinity immunoglobulin epsilon receptor 1 (Fc epsilon RI). N-glycosylated. N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal. Mice appear healthy, and have normal numbers of peripheral lymphocytes, eosinophils and neutrophils. Basophil numbers are normal in bone marrow, but are markedly increased in peripheral blood and spleen. Likewise, mutant mice have an increased number of mast cells in the small and large intestine. Both mast cells and basophils show increased proliferation in response to extracellular ATP. Mutant mice display normal immediate reaction to allergens, but strongly increased chronic allergic inflammation in skin, intestine and lung that lead to severe tissue damage. Extracellular ATP levels are normal in the absence of allergen, and strongly increased after exposure to allergen, due to impaired clearance of extracellular ATP (PubMed:25692702). Mutant mice display increased levels of extracellular ATP in the lumen of the small intestine. They have decreased numbers of plasmacytoid dendritic cells in the small intestine lamia propria and in Peyer patches; the decrease is due to increased ATP levels that cause increased apoptosis of plasmacytoid dendritic cells (PubMed:28225814). basophil activation involved in immune response nucleic acid binding catalytic activity phosphodiesterase I activity nucleotide diphosphatase activity scavenger receptor activity calcium ion binding extracellular region plasma membrane pyrimidine nucleotide metabolic process phosphate-containing compound metabolic process endocytosis immune response metabolic process zinc ion binding nucleoside triphosphate catabolic process external side of plasma membrane membrane integral component of membrane apical plasma membrane hydrolase activity polysaccharide binding negative regulation of mast cell activation involved in immune response NADH pyrophosphatase activity ATP metabolic process metal ion binding nucleoside-triphosphate diphosphatase activity perinuclear region of cytoplasm negative regulation of inflammatory response negative regulation of mast cell proliferation nucleic acid phosphodiester bond hydrolysis uc007era.1 uc007era.2 uc007era.3 
ENSMUST00000020171.12 Ccn2 ENSMUST00000020171.12 cellular communication network factor 2 (from RefSeq NM_010217.2) CCN2_MOUSE Ccn2 Ctgf ENSMUST00000020171.1 ENSMUST00000020171.10 ENSMUST00000020171.11 ENSMUST00000020171.2 ENSMUST00000020171.3 ENSMUST00000020171.4 ENSMUST00000020171.5 ENSMUST00000020171.6 ENSMUST00000020171.7 ENSMUST00000020171.8 ENSMUST00000020171.9 Fisp-12 Fisp12 G5E830 Hcs24 NM_010217 P29268 Q922U0 betaIG-M2 uc011xbr.1 uc011xbr.2 uc011xbr.3 uc011xbr.4 Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). Monomer (By similarity). Interacts with TSKU (PubMed:30232710). Secreted, extracellular space, extracellular matrix Secreted Testis, spleen, kidney, lung, heart, and brain (lowest level in testis and highest in lung). By growth factors. Belongs to the CCN family. cartilage condensation ossification angiogenesis tissue homeostasis positive regulation of protein phosphorylation fibronectin binding integrin binding insulin-like growth factor binding extracellular region extracellular space cis-Golgi network cytosol cell cortex cell adhesion cell-matrix adhesion integrin-mediated signaling pathway aging protein C-terminus binding growth factor activity heparin binding positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway response to glucose positive regulation of gene expression negative regulation of gene expression positive regulation of cell death response to organic cyclic compound cell migration cell differentiation lung development extracellular matrix regulation of chondrocyte differentiation response to estradiol positive regulation of collagen biosynthetic process response to anoxia intracellular signal transduction chondrocyte proliferation response to amino acid positive regulation of cysteine-type endopeptidase activity involved in apoptotic process response to peptide hormone positive regulation of cell differentiation positive regulation of JNK cascade perinuclear region of cytoplasm positive regulation of cell activation response to mineralocorticoid positive regulation of stress fiber assembly cytosolic calcium ion transport positive regulation of cardiac muscle contraction negative regulation of cell death connective tissue development extracellular matrix constituent secretion positive regulation of G0 to G1 transition positive regulation of ERK1 and ERK2 cascade response to fatty acid DNA biosynthetic process reactive oxygen species metabolic process uc011xbr.1 uc011xbr.2 uc011xbr.3 uc011xbr.4 
ENSMUST00000020182.16 Pex7 ENSMUST00000020182.16 peroxisomal biogenesis factor 7, transcript variant 1 (from RefSeq NM_008822.2) A2RSR2 ENSMUST00000020182.1 ENSMUST00000020182.10 ENSMUST00000020182.11 ENSMUST00000020182.12 ENSMUST00000020182.13 ENSMUST00000020182.14 ENSMUST00000020182.15 ENSMUST00000020182.2 ENSMUST00000020182.3 ENSMUST00000020182.4 ENSMUST00000020182.5 ENSMUST00000020182.6 ENSMUST00000020182.7 ENSMUST00000020182.8 ENSMUST00000020182.9 NM_008822 P97865 PEX7_MOUSE Pex7 uc007enl.1 uc007enl.2 uc007enl.3 uc007enl.4 Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal (PubMed:9090381, PubMed:12915479). Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol (By similarity). Cargo protein-binding triggers interaction with PEX5 and formation of a ternary complex composed of PEX5 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex (By similarity). Interacts with PEX5; interaction only takes place when PEX7 is associated with cargo proteins (By similarity). Interacts with VWA8 (By similarity). Cytoplasm, cytosol Peroxisome matrix Note=Translocated into the peroxisome matrix together with PTS2-containing cargo proteins and PEX5. Mice were born alive, but display a variable degree of dwarfism and hypotonia with decreased motility, hampering their feeding (PubMed:12915479). Perinatal lethality is frequent, although some mice survive beyond 18 months (PubMed:12915479). In the intermediate zone of the developing cerebral cortex, increased neuronal density is observed (PubMed:12915479). Increased neuronal density is caused by defects in neuronal migration (PubMed:12915479). Mice also show defects in ossification of distal bone elements of the limbs as well as parts of the skull and vertebrae (PubMed:12915479). Cells display normal peroxisome assembly, but show impaired peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal (PubMed:12915479). Biochemically, cells show severe depletion of plasmalogens, impaired alpha-oxidation of phytanic acid and impaired beta-oxidation of very-long-chain fatty acids (PubMed:12915479). Belongs to the WD repeat peroxin-7 family. neuron migration endochondral ossification peroxisome matrix targeting signal-2 binding cytoplasm peroxisome peroxisomal matrix cytosol protein targeting to peroxisome fatty acid beta-oxidation peroxisome organization ether lipid biosynthetic process protein transport protein import into peroxisome matrix enzyme binding protein homodimerization activity uc007enl.1 uc007enl.2 uc007enl.3 uc007enl.4 
ENSMUST00000020185.5 Il20ra ENSMUST00000020185.5 interleukin 20 receptor, alpha (from RefSeq NM_172786.2) ENSMUST00000020185.1 ENSMUST00000020185.2 ENSMUST00000020185.3 ENSMUST00000020185.4 I20RA_MOUSE NM_172786 Q6PHB0 Q8BW64 uc007eni.1 uc007eni.2 uc007eni.3 The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 (By similarity). Heterodimer with IL20RB and heterodimer with IL10RB. Membrane ; Single-pass type I membrane protein Belongs to the type II cytokine receptor family. cytokine receptor activity plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway interleukin-20 binding regulation of bone resorption positive regulation of intrinsic apoptotic signaling pathway uc007eni.1 uc007eni.2 uc007eni.3 
ENSMUST00000020188.13 Ifngr1 ENSMUST00000020188.13 interferon gamma receptor 1 (from RefSeq NM_010511.3) ENSMUST00000020188.1 ENSMUST00000020188.10 ENSMUST00000020188.11 ENSMUST00000020188.12 ENSMUST00000020188.2 ENSMUST00000020188.3 ENSMUST00000020188.4 ENSMUST00000020188.5 ENSMUST00000020188.6 ENSMUST00000020188.7 ENSMUST00000020188.8 ENSMUST00000020188.9 INGR1_MOUSE Ifngr Ifngr1 NM_010511 P15261 Q91Y85 uc007eng.1 uc007eng.2 uc007eng.3 Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (, PubMed:20926559, PubMed:27286456). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:2530582, PubMed:2532365, PubMed:2137461, PubMed:2531896, PubMed:2530216). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:19889125). STAT3 can also be activated in a similar manner although activation seems weaker (PubMed:15284232). IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (PubMed:15522878). Monomer. Heterodimer with IFNGR2, to form the IFNG receptor complex. Interacts with JAK1. Interacts (when phosphorylated) with STAT1 (By similarity). Interacts with SOCS1 (PubMed:15522878). Cell membrane ingle-pass type I membrane protein Phosphorylated at Ser/Thr residues. Phosphorylation of Tyr-445 is required for IFNG receptor signal transduction. Influenza virus infection leads to phosphorylation in a CSNK1A1-dependent manner. Ubiquitinated after phosphorylation in a CSNK1A1-dependent manner, leading to the lysosome-dependent degradation. Proteasomally degraded through 'Lys-48'-mediated ubiquitination. Ubiquitination is necessary for efficient IFNGR1 signaling. Deletion mutants show shortened lifespan and enhanced intestinal tumorigenesis. These tumors exhibit increased inflammation (PubMed:27286456). Loss of STAT1 signaling pathway activation is also observed (PubMed:19889125). After viral infection such as junin virus, mice develop disseminated infection and severe disease (PubMed:20926559). Belongs to the type II cytokine receptor family. Sequence=AAA37895.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; microglial cell activation cytokine receptor activity endoplasmic reticulum plasma membrane positive regulation of gene expression postsynaptic density membrane integral component of membrane cytokine-mediated signaling pathway cytokine binding dendrite vesicle astrocyte activation defense response to virus negative regulation of beta-amyloid clearance positive regulation of beta-amyloid formation positive regulation of tumor necrosis factor secretion positive regulation of NMDA glutamate receptor activity uc007eng.1 uc007eng.2 uc007eng.3 
ENSMUST00000020190.8 Vnn3 ENSMUST00000020190.8 vanin 3 (from RefSeq NM_011979.2) E9QMT9 ENSMUST00000020190.1 ENSMUST00000020190.2 ENSMUST00000020190.3 ENSMUST00000020190.4 ENSMUST00000020190.5 ENSMUST00000020190.6 ENSMUST00000020190.7 NM_011979 Q9QZ25 VNN3_MOUSE uc007eqb.1 uc007eqb.2 uc007eqb.3 Cell membrane ; Lipid-anchor, GPI- anchor Note=According to PubMed:11491533, secreted. Ubiquitous with higher expression in liver. Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. Sequence=CAB59323.1; Type=Erroneous initiation; Evidence=; extracellular space plasma membrane nitrogen compound metabolic process pantothenate metabolic process membrane hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides pantetheine hydrolase activity anchored component of membrane uc007eqb.1 uc007eqb.2 uc007eqb.3 
ENSMUST00000020203.7 Snrpf ENSMUST00000020203.7 small nuclear ribonucleoprotein polypeptide F (from RefSeq NM_027246.1) ENSMUST00000020203.1 ENSMUST00000020203.2 ENSMUST00000020203.3 ENSMUST00000020203.4 ENSMUST00000020203.5 ENSMUST00000020203.6 NM_027246 Q497K3 Q497K3_MOUSE Snrpf uc007guw.1 uc007guw.2 uc007guw.3 uc007guw.4 Nucleus Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily. spliceosomal snRNP assembly mRNA splicing, via spliceosome RNA binding nucleus spliceosomal complex U7 snRNP U1 snRNP U4 snRNP U12-type spliceosomal complex small nucleolar ribonucleoprotein complex cytosol mRNA processing RNA splicing small nuclear ribonucleoprotein complex methylosome pICln-Sm protein complex SMN-Sm protein complex U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome uc007guw.1 uc007guw.2 uc007guw.3 uc007guw.4 
ENSMUST00000020204.5 Ntn4 ENSMUST00000020204.5 netrin 4 (from RefSeq NM_021320.3) E9QMT3 ENSMUST00000020204.1 ENSMUST00000020204.2 ENSMUST00000020204.3 ENSMUST00000020204.4 NET4_MOUSE NM_021320 Q9JI33 uc007gux.1 uc007gux.2 uc007gux.3 uc007gux.4 May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants. May form a homodimer. Q9JI33; P02468: Lamc1; NbExp=2; IntAct=EBI-15755373, EBI-7059830; Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. Expressed in kidney, liver, heart, ovary, testis, retina, brain, olfactory bulb, and widely expressed in embryo. protein binding extracellular region basement membrane plasma membrane animal organ morphogenesis tissue development neuron remodeling cell migration substrate adhesion-dependent cell spreading laminin-1 binding laminin complex regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling basement membrane assembly uc007gux.1 uc007gux.2 uc007gux.3 uc007gux.4 
ENSMUST00000020208.5 Fgd6 ENSMUST00000020208.5 FYVE, RhoGEF and PH domain containing 6 (from RefSeq NM_053072.3) ENSMUST00000020208.1 ENSMUST00000020208.2 ENSMUST00000020208.3 ENSMUST00000020208.4 FGD6_MOUSE Kiaa1362 NM_053072 Q69ZL1 Q8C8W5 Q8K3B0 Q9D3Y7 uc011xlz.1 uc011xlz.2 May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). Cytoplasm Cytoplasm, cytoskeleton Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69ZL1-1; Sequence=Displayed; Name=2; IsoId=Q69ZL1-2; Sequence=VSP_013093; Sequence=BAD32435.1; Type=Erroneous initiation; Evidence=; molecular_function guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cellular_component cytoplasm cytoskeleton biological_process regulation of Rho protein signal transduction regulation of GTPase activity metal ion binding uc011xlz.1 uc011xlz.2 
ENSMUST00000020209.16 Ndufa12 ENSMUST00000020209.16 NADH:ubiquinone oxidoreductase subunit A12, transcript variant 1 (from RefSeq NM_025551.4) ENSMUST00000020209.1 ENSMUST00000020209.10 ENSMUST00000020209.11 ENSMUST00000020209.12 ENSMUST00000020209.13 ENSMUST00000020209.14 ENSMUST00000020209.15 ENSMUST00000020209.2 ENSMUST00000020209.3 ENSMUST00000020209.4 ENSMUST00000020209.5 ENSMUST00000020209.6 ENSMUST00000020209.7 ENSMUST00000020209.8 ENSMUST00000020209.9 NDUAC_MOUSE NM_025551 Q3TIA0 Q7TMF3 uc007gvq.1 uc007gvq.2 uc007gvq.3 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the complex I NDUFA12 subunit family. Sequence=BAB26955.2; Type=Erroneous initiation; Evidence=; molecular_function mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I cytosol response to oxidative stress NADH dehydrogenase (ubiquinone) activity electron carrier activity membrane mitochondrial ATP synthesis coupled electron transport oxidation-reduction process respiratory chain uc007gvq.1 uc007gvq.2 uc007gvq.3 
ENSMUST00000020212.6 Cep83 ENSMUST00000020212.6 centrosomal protein 83 (from RefSeq NM_029852.2) CEP83_MOUSE Ccdc41 ENSMUST00000020212.1 ENSMUST00000020212.2 ENSMUST00000020212.3 ENSMUST00000020212.4 ENSMUST00000020212.5 NM_029852 Q3U7X7 Q3UX57 Q80VF0 Q9D5R3 uc007gvx.1 uc007gvx.2 uc007gvx.3 Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly. Interacts with CEP164 and IFT20. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to centrioles at all stages of the cell cycle, including mitosis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D5R3-1; Sequence=Displayed; Name=2; IsoId=Q9D5R3-2; Sequence=VSP_018333; Belongs to the CEP83 family. molecular_function cytoplasm Golgi apparatus centriole cytoskeleton cell projection organization vesicle docking establishment of centrosome localization cilium assembly protein localization to centrosome ciliary transition fiber uc007gvx.1 uc007gvx.2 uc007gvx.3 
ENSMUST00000020215.16 Socs2 ENSMUST00000020215.16 suppressor of cytokine signaling 2, transcript variant 1 (from RefSeq NM_007706.4) Cish2 ENSMUST00000020215.1 ENSMUST00000020215.10 ENSMUST00000020215.11 ENSMUST00000020215.12 ENSMUST00000020215.13 ENSMUST00000020215.14 ENSMUST00000020215.15 ENSMUST00000020215.2 ENSMUST00000020215.3 ENSMUST00000020215.4 ENSMUST00000020215.5 ENSMUST00000020215.6 ENSMUST00000020215.7 ENSMUST00000020215.8 ENSMUST00000020215.9 NM_007706 Q548Q7 Q548Q7_MOUSE Socs2 uc007gwg.1 uc007gwg.2 uc007gwg.3 Protein modification; protein ubiquitination. regulation of cell growth insulin-like growth factor receptor binding cytoplasm JAK pathway signal transduction adaptor activity protein ubiquitination response to estradiol cellular response to hormone stimulus intracellular signal transduction negative regulation of JAK-STAT cascade growth hormone receptor signaling pathway uc007gwg.1 uc007gwg.2 uc007gwg.3 
ENSMUST00000020217.7 Nudt4 ENSMUST00000020217.7 nudix hydrolase 4, transcript variant 2 (from RefSeq NM_027722.5) Dipp2 ENSMUST00000020217.1 ENSMUST00000020217.2 ENSMUST00000020217.3 ENSMUST00000020217.4 ENSMUST00000020217.5 ENSMUST00000020217.6 NM_027722 NUDT4_MOUSE Nudt4 Q8BXB9 Q8R2U6 Q9D3T6 uc007gwp.1 uc007gwp.2 uc007gwp.3 uc007gwp.4 Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (By similarity). Can also catalyze the hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) but not diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) and the major reaction products are ADP and p4a from Ap6A (By similarity). Also able to hydrolyze 5-phosphoribose 1-diphosphate (By similarity). Does not play a role in U8 snoRNA decapping activity (PubMed:16141072). Binds U8 snoRNA (PubMed:16141072). Reaction=diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.; EC=3.6.1.52; Evidence=; Reaction=5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + H(+) + phosphate; Xref=Rhea:RHEA:22384, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58130, ChEBI:CHEBI:58628; EC=3.6.1.52; Evidence=; Reaction=3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate; Xref=Rhea:RHEA:56312, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:140372, ChEBI:CHEBI:140374; EC=3.6.1.52; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 3 Mg(2+) or Mn(2+) ions per subunit. ; Cytoplasm Belongs to the Nudix hydrolase family. DIPP subfamily. endopolyphosphatase activity RNA binding nucleus cytoplasm cytosol diphosphoinositol-polyphosphate diphosphatase activity hydrolase activity snoRNA binding bis(5'-adenosyl)-hexaphosphatase activity bis(5'-adenosyl)-pentaphosphatase activity metal ion binding m7G(5')pppN diphosphatase activity inositol diphosphate tetrakisphosphate diphosphatase activity inositol diphosphate pentakisphosphate diphosphatase activity diphosphoinositol polyphosphate metabolic process diadenosine pentaphosphate catabolic process diadenosine hexaphosphate catabolic process adenosine 5'-(hexahydrogen pentaphosphate) catabolic process uc007gwp.1 uc007gwp.2 uc007gwp.3 uc007gwp.4 
ENSMUST00000020220.15 Nuak1 ENSMUST00000020220.15 NUAK family, SNF1-like kinase, 1 (from RefSeq NM_001004363.2) ENSMUST00000020220.1 ENSMUST00000020220.10 ENSMUST00000020220.11 ENSMUST00000020220.12 ENSMUST00000020220.13 ENSMUST00000020220.14 ENSMUST00000020220.2 ENSMUST00000020220.3 ENSMUST00000020220.4 ENSMUST00000020220.5 ENSMUST00000020220.6 ENSMUST00000020220.7 ENSMUST00000020220.8 ENSMUST00000020220.9 Kiaa0537 NM_001004363 NUAK1_MOUSE Omphk1 Q641K5 Q6I6D6 Q8CGE1 uc007gko.1 uc007gko.2 uc007gko.3 uc007gko.4 Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation on Thr-212. Activated by phosphorylation at Ser-601 AKT1 during glucose starvation; the relevance of such activation in normal cells is however unsure (By similarity). Interacts (via GILK motif) with PPP1CB; the interaction is direct and bridges NUAK1 and PPP1R12A. Interacts with CDKN1A. Nucleus Cytoplasm Expressed in the developing central nervous system, in epidermis, and some other tissues. At 7.5 dpc, expressed in allantois and anterior visceral endoderm. In the embryonic part, present in mesoderm migrating laterally but not in the primitive streak; the expression is not apparent in ectoderm or endoderm at this stage. At 8.5 dpc, no expression is found in mesodermal tissues, while it is expressed in midbrain and isthmic regions of the neuroectoderm; it is also found in the pharyngeal region of the foregut. At 9.5 dpc, the expression is found throughout the undifferentiated neuroectoderm, except the telencephalic region. The expression is also ubiquitous in the epidermis; it is especially apparent in the ventral body wall. Also expressed in dorsal root ganglia of neural crest origin. The expression persists in the anterior gut and is also found in bulb arteriosus, kidney, and several connective tissues. At 12.5 dpc, the expression is greatly reduced in most of the neuroectoderm, but some expression remains in pons, anterior tectum, tegmentum, pretectum, prethalamus, mammillary region and hypothalamus. In telencephalon, expression is present in the differentiating preplate of the cortex. The expression is sustained in the epidermis of the whole body. In 14.5 and 18.5 dpc brain, expressed in differentiated fields of the cortex; no significant expression is found in other parts of brain or in the spinal cord. The expression is also present in a variety of connective tissues and in the epidermis of the whole body. The GILK motif mediates interaction with PPP1CB. Phosphorylated at Thr-212 by STK11/LKB1 in complex with STE20- related adapter-alpha (STRADA) pseudo kinase and CAB39. Not dephosphorylated by the myosin PP1 complex when regulating its activity, due to the presence of PPP1R12A, which prevents myosin PP1 from dephosphorylating NUAK1. Phosphorylated by STK38L upon stimulation with IGF1 (By similarity). Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X (By similarity). Lethal during development, no live-born. At 18.5 dpc, homozygous mutants suffer from omphalocele with a failure in closure of the secondary body wall leading to organs outside of the abdomen. Omphalocele are apparent at 14.5 dpc when the physiological hernia is almost rectified in wild-type embryos. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. nucleotide binding fibrillar center p53 binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation cellular response to DNA damage stimulus cell adhesion microtubule cytoskeleton kinase activity phosphorylation transferase activity regulation of cell adhesion regulation of myosin-light-chain-phosphatase activity intracellular signal transduction regulation of cellular senescence uc007gko.1 uc007gko.2 uc007gko.3 uc007gko.4 
ENSMUST00000020223.8 Tcp11l2 ENSMUST00000020223.8 t-complex 11 (mouse) like 2 (from RefSeq NM_146008.2) ENSMUST00000020223.1 ENSMUST00000020223.2 ENSMUST00000020223.3 ENSMUST00000020223.4 ENSMUST00000020223.5 ENSMUST00000020223.6 ENSMUST00000020223.7 NM_146008 Q8C2D5 Q8K1H7 T11L2_MOUSE Tcp11l2 uc007gks.1 uc007gks.2 uc007gks.3 Promotes the migration of muscle-derived satellite cells (MDSCs) during differentiation throught interaction with FMNL2 and therefore may participate in microfilament assembly. Interacts with FMNL2; this interaction promotes muscle-derived satellite cell (MDSC) migration and differentiation. Cytoplasm, cytoskeleton Note=Accumulates around the actin complex before the formation of microfilament bundles and microtubule extension. Belongs to the TCP11 family. Sequence=BAC40581.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component biological_process uc007gks.1 uc007gks.2 uc007gks.3 
ENSMUST00000020227.11 Cry1 ENSMUST00000020227.11 cryptochrome circadian regulator 1 (from RefSeq NM_007771.3) CRY1_MOUSE ENSMUST00000020227.1 ENSMUST00000020227.10 ENSMUST00000020227.2 ENSMUST00000020227.3 ENSMUST00000020227.4 ENSMUST00000020227.5 ENSMUST00000020227.6 ENSMUST00000020227.7 ENSMUST00000020227.8 ENSMUST00000020227.9 NM_007771 P97784 uc007gle.1 uc007gle.2 uc007gle.3 This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of this gene results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Feb 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085499.1, AK133818.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post- translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-BMAL1 independently of PER proteins and is found at CLOCK-BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1, ATF4, MTA1, KLF10 and NAMPT. May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Inhibits hepatic gluconeogenesis by decreasing nuclear FOXO1 levels that down-regulates gluconeogenic gene expression. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (PubMed:28683290). Plays an essential role in the generation of circadian rhythms in the retina (PubMed:29561690). Represses the transcriptional activity of NR1I2 (PubMed:28751364). Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. Only a minority of the protein molecules contain bound FAD. Contrary to the situation in photolyases, the FAD is bound in a shallow, surface-exposed pocket. ; Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate; Xref=ChEBI:CHEBI:15636; Evidence=; Note=Binds 1 5,10-methenyltetrahydrofolate (MTHF) non-covalently per subunit. ; KL001 (N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N- (2-furanylmethyl)-methanesulfonamide) binds to CRY1 and stabilizes it by inhibiting FBXL3- and ubiquitin-dependent degradation of CRY1 resulting in lengthening of the circadian periods. KL001-mediated CRY1 stabilization can inhibit glucagon-induced gluconeogenesis in primary hepatocytes. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins (PubMed:11779462). Interacts directly with TIMELESS (PubMed:10428031, PubMed:24489120, PubMed:23418588). Interacts directly with PER1 and PER2; interaction with PER2 inhibits its ubiquitination and vice versa (PubMed:10428031, PubMed:11889036, PubMed:11875063, PubMed:14701732, PubMed:16478995, PubMed:23746849, PubMed:23418588, PubMed:21613214, PubMed:20159955). Interacts with PER3 (PubMed:10428031, PubMed:14701732). Interacts with FBXL21 (PubMed:18953409, PubMed:23452855, PubMed:23452856). Interacts with FBXL3 (PubMed:17462724, PubMed:23746849, PubMed:23452855, PubMed:23452856, PubMed:30500822). Interacts with PPP5C (via TPR repeats) (By similarity). Interacts with CLOCK-BMAL1 independently of PER2 and DNA (PubMed:21613214). Interacts with HDAC1, HDAC2 and SIN3B (PubMed:15226430). Interacts with nuclear receptors AR, NR1D1, NR3C1/GR, RORA and RORC; the interaction with at least NR3C1/GR is ligand dependent (PubMed:22170608, PubMed:28751364). Interacts with PRKDC (PubMed:24158435). Interacts with the G protein subunit alpha GNAS; the interaction may block GPCR-mediated regulation of cAMP concentrations (By similarity). Interacts with PRMT5 (PubMed:23133559). Interacts with EZH2 (PubMed:16717091). Interacts with MYBBP1A, DOCK7, HNRNPU, RPL7A, RPL8 and RPS3 (PubMed:19129230). Interacts with MAP1LC3B (PubMed:29937374). Interacts with CLOCK (PubMed:16717091, PubMed:19917250). Interacts with BMAL1 (PubMed:26776516, PubMed:16717091, PubMed:19917250, PubMed:23746849). Interacts weakly with HDAC3; this interaction is enhanced in the presence of FBXL3 (PubMed:26776516). Interacts with TRIM28, KCTD5 and DDB1 (PubMed:27123980). Interacts with DTL (By similarity). Interacts with DDB1-CUL4A complex (PubMed:26431207). Interacts with FOXO1 (PubMed:28790135). Interacts with PSMD2 in a KDM8-dependent manner (PubMed:30500822). Interacts with KDM8 in a FBXL3-dependent manner (PubMed:30500822). Interacts with PPARA (PubMed:28683290). Interacts with PPARG in a ligand-dependent manner (PubMed:28683290). Interacts with PPARD (via domain NR LBD) in a ligand-dependent manner (PubMed:28683290, PubMed:28751364). Interacts with NR1I2 (via domain NR LBD) in a ligand-dependent manner (PubMed:28751364). Interacts with NR1I3, VDR and HNF4A (PubMed:28751364). P97784; Q9WTL8: Bmal1; NbExp=23; IntAct=EBI-1266607, EBI-644534; P97784; Q9WTL8-2: Bmal1; NbExp=4; IntAct=EBI-1266607, EBI-644559; P97784; Q9WTL8-4: Bmal1; NbExp=4; IntAct=EBI-1266607, EBI-644568; P97784; Q2VPD4: Bmal2; NbExp=3; IntAct=EBI-1266607, EBI-9696862; P97784; O08785: Clock; NbExp=10; IntAct=EBI-1266607, EBI-79859; P97784; P67871: Csnk2b; NbExp=4; IntAct=EBI-1266607, EBI-348179; P97784; Q8BFZ4: Fbxl21; NbExp=10; IntAct=EBI-1266607, EBI-6898235; P97784; Q8C4V4: Fbxl3; NbExp=12; IntAct=EBI-1266607, EBI-1266589; P97784; P06537-1: Nr3c1; NbExp=3; IntAct=EBI-1266607, EBI-15959147; P97784; O35973: Per1; NbExp=3; IntAct=EBI-1266607, EBI-1266764; P97784; O54943: Per2; NbExp=22; IntAct=EBI-1266607, EBI-1266779; P97784; Q8CIG8: Prmt5; NbExp=2; IntAct=EBI-1266607, EBI-2527009; P97784; P67870: CSNK2B; Xeno; NbExp=2; IntAct=EBI-1266607, EBI-348169; Cytoplasm Nucleus Note=Transloctaed to the nucleus through interaction with other clock proteins such as PER2 or BMAL1. Expressed in cones, amacrine cells, and retinal ganglion cells of the retina (at protein level) (PubMed:29561690). Expressed in all tissues examined including heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Higher levels in brain, liver and testis. In the retina, highly expressed in the ganglion cell layer (GCL) and in the inner nuclear layer (INL). Evenly distributed in central and peripheral retina. In the brain, highly expressed in the suprachiasmatic nucleus (SCN). High levels in cerebral cortical layers particularly in the pyramidial cell layer of the hippocampus, the granular cell layer of the dentate gyrus (DG) and the pyramidal cell layer of the piriform cortex (PFC). Oscillates diurnally, rhythmic expression in the early night is critical for clock function (at protein level). In SCN, exhibits circadian rhythm expression with highest levels during the light phase at CT10. No detectable expression after 8 hours in the dark. Circadian oscillations also observed in liver, skeletal muscle and cerebellum, but not in testis. The LIR motifs (LC3-interacting region) 3 and 5 are required for its interaction with MAP1LC3B and for its autophagy-mediated degradation. Phosphorylation on Ser-247 by MAPK is important for the inhibition of CLOCK-BMAL1-mediated transcriptional activity. Phosphorylation by CSNK1E requires interaction with PER1 or PER2. Phosphorylation at Ser- 71 and Ser-280 by AMPK decreases protein stability. Phosphorylation at Ser-588 exhibits a robust circadian rhythm with a peak at CT8, increases protein stability, prevents SCF(FBXL3)-mediated degradation and is antagonized by interaction with PRKDC. Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complexes, regulating the balance between degradation and stabilization. The SCF(FBXL3) complex is mainly nuclear and mediates ubiquitination and subsequent degradation of CRY1. In contrast, cytoplasmic SCF(FBXL21) complex-mediated ubiquitination leads to stabilize CRY1 and counteract the activity of the SCF(FBXL3) complex. The SCF(FBXL3) and SCF(FBXL21) complexes probably mediate ubiquitination at different Lys residues. Ubiquitination at Lys-11 and Lys-107 are specifically ubiquitinated by the SCF(FBXL21) complex but not by the SCF(FBXL3) complex. Ubiquitination may be inhibited by PER2. Deubiquitinated by USP7 (PubMed:27123980). Undergoes autophagy-mediated degradation in the liver in a time- dependent manner. Autophagic degradation of CRY1 (an inhibitor of gluconeogenesis) occurs during periods of reduced feeding allowing induction of gluconeogenesis and maintenance of blood glucose levels. Mice show an advanced phase shift (around 4 hours) in the expression of DBP, NR1D1 and PER1 genes in the liver. Double knockouts of CRY1 and CRY2 show slightly decrease body weight and lose the cycling rhythmicity of feeding behavior, energy expenditure and glucocorticoids expression. Glucose homeostasis is severely disrupted and animals exhibit elevated blood glucose in response to acute feeding after an overnight fast as well as severely impaired glucose clearance in a glucose tolerance test. When challenged with high-fat diet, animals rapidly gain weight and surpass that of wild-type mice, despite displaying hypophagia. They exhibit hyperinsulinemia and selective insulin resistance in the liver and muscle but show high insulin sensitivity in adipose tissue and consequent increased lipid uptake. Mice display enlarged gonadal, subcutaneous and perirenal fat deposits with adipocyte hypertrophy and increased lipied accumulation in liver. Mice show loss of circadian rhythms in photopic ERG b-wave amplitudes, visual contrast sensitivity and pupillary light responses, with reduced robustness and stability of bioluminescent rhythms (PubMed:29561690). Both single CRY1 knockout and double CRY1 and CRY2 knockout mice show increased exercise performance and increased mitochondrial reserve capacity in primary myotubes (PubMed:28683290). Belongs to the DNA photolyase class-1 family. negative regulation of transcription from RNA polymerase II promoter nucleotide binding double-stranded DNA binding protein binding nucleus nucleoplasm cytoplasm mitochondrion cytosol gluconeogenesis DNA damage induced protein phosphorylation circadian rhythm transcription factor binding response to light stimulus photoreceptor activity response to activity protein-chromophore linkage kinase binding protein kinase binding phosphatase binding lipid storage negative regulation of protein ubiquitination positive regulation of protein ubiquitination response to insulin circadian regulation of gene expression response to glucagon nuclear hormone receptor binding glucose homeostasis regulation of circadian rhythm negative regulation of circadian rhythm histone deacetylase binding entrainment of circadian clock by photoperiod negative regulation of gluconeogenesis negative regulation of G-protein coupled receptor protein signaling pathway negative regulation of transcription, DNA-templated rhythmic process response to stimulus E-box binding regulation of DNA damage checkpoint negative regulation of glucocorticoid receptor signaling pathway negative regulation of glucocorticoid secretion uc007gle.1 uc007gle.2 uc007gle.3 
ENSMUST00000020234.14 Timp3 ENSMUST00000020234.14 tissue inhibitor of metalloproteinase 3 (from RefSeq NM_011595.2) ENSMUST00000020234.1 ENSMUST00000020234.10 ENSMUST00000020234.11 ENSMUST00000020234.12 ENSMUST00000020234.13 ENSMUST00000020234.2 ENSMUST00000020234.3 ENSMUST00000020234.4 ENSMUST00000020234.5 ENSMUST00000020234.6 ENSMUST00000020234.7 ENSMUST00000020234.8 ENSMUST00000020234.9 NM_011595 Q54AE5 Q54AE5_MOUSE Timp3 uc007gnr.1 uc007gnr.2 uc007gnr.3 Interacts with EFEMP1. Secreted, extracellular space, extracellular matrix Belongs to the protease inhibitor I35 (TIMP) family. extracellular region metalloendopeptidase inhibitor activity negative regulation of endopeptidase activity negative regulation of membrane protein ectodomain proteolysis negative regulation of ERK1 and ERK2 cascade positive regulation of TRAIL-activated apoptotic signaling pathway uc007gnr.1 uc007gnr.2 uc007gnr.3 
ENSMUST00000020238.14 Hsp90b1 ENSMUST00000020238.14 heat shock protein 90, beta (Grp94), member 1 (from RefSeq NM_011631.1) ENSMUST00000020238.1 ENSMUST00000020238.10 ENSMUST00000020238.11 ENSMUST00000020238.12 ENSMUST00000020238.13 ENSMUST00000020238.2 ENSMUST00000020238.3 ENSMUST00000020238.4 ENSMUST00000020238.5 ENSMUST00000020238.6 ENSMUST00000020238.7 ENSMUST00000020238.8 ENSMUST00000020238.9 Hsp90b1 NM_011631 Q3UAD6 Q3UAD6_MOUSE Tra1 uc007gqi.1 uc007gqi.2 uc007gqi.3 Endoplasmic reticulum lumen Melanosome Sarcoplasmic reticulum lumen Belongs to the heat shock protein 90 family. response to hypoxia RNA binding ATP binding endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane cytosol protein folding protein phosphatase binding ER-associated ubiquitin-dependent protein catabolic process midbody retrograde protein transport, ER to cytosol actin rod assembly macromolecular complex negative regulation of apoptotic process regulation of phosphoprotein phosphatase activity perinuclear region of cytoplasm low-density lipoprotein particle receptor binding unfolded protein binding cellular response to ATP uc007gqi.1 uc007gqi.2 uc007gqi.3 
ENSMUST00000020241.17 Pah ENSMUST00000020241.17 phenylalanine hydroxylase (from RefSeq NM_008777.3) ENSMUST00000020241.1 ENSMUST00000020241.10 ENSMUST00000020241.11 ENSMUST00000020241.12 ENSMUST00000020241.13 ENSMUST00000020241.14 ENSMUST00000020241.15 ENSMUST00000020241.16 ENSMUST00000020241.2 ENSMUST00000020241.3 ENSMUST00000020241.4 ENSMUST00000020241.5 ENSMUST00000020241.6 ENSMUST00000020241.7 ENSMUST00000020241.8 ENSMUST00000020241.9 NM_008777 P16331 PH4H_MOUSE Q91WV1 uc007gqt.1 uc007gqt.2 uc007gqt.3 uc007gqt.4 Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Reaction=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L- tyrosine; Xref=Rhea:RHEA:20273, ChEBI:CHEBI:15379, ChEBI:CHEBI:15642, ChEBI:CHEBI:58095, ChEBI:CHEBI:58315, ChEBI:CHEBI:59560; EC=1.14.16.1; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; N-terminal region of PAH is thought to contain allosteric binding sites for phenylalanine and to constitute an 'inhibitory' domain that regulates the activity of a catalytic domain in the C-terminal portion of the molecule. Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. Homodimer and homotetramer. Phosphorylation at Ser-16 increases basal activity and facilitates activation by the substrate phenylalanine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. catalytic activity monooxygenase activity phenylalanine 4-monooxygenase activity iron ion binding L-phenylalanine metabolic process L-phenylalanine catabolic process tyrosine biosynthetic process metabolic process aromatic amino acid family metabolic process oxidoreductase activity amino acid binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen protein hydroxylation pteridine-containing compound metabolic process protein homodimerization activity tetrahydrobiopterin metabolic process metal ion binding cofactor binding oxidation-reduction process uc007gqt.1 uc007gqt.2 uc007gqt.3 uc007gqt.4 
ENSMUST00000020243.10 Ascl1 ENSMUST00000020243.10 achaete-scute family bHLH transcription factor 1 (from RefSeq NM_008553.5) ASCL1_MOUSE Ascl1 Ash1 ENSMUST00000020243.1 ENSMUST00000020243.2 ENSMUST00000020243.3 ENSMUST00000020243.4 ENSMUST00000020243.5 ENSMUST00000020243.6 ENSMUST00000020243.7 ENSMUST00000020243.8 ENSMUST00000020243.9 Mash-1 Mash1 NM_008553 Q02067 Q7TNT5 uc007gqs.1 uc007gqs.2 uc007gqs.3 Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways (PubMed:24243019). Directly binds the E box motif (5'-CANNTG- 3') on promoters and promotes transcription of neuronal genes (PubMed:20107439, PubMed:24243019, PubMed:27281220). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS (PubMed:8217843). Essential for the generation of olfactory and autonomic neurons (PubMed:8221886). Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation (PubMed:16020526, PubMed:17728344). Involved in the regulation of neuroendocrine cell development in the glandular stomach (PubMed:18173746). Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3. Nucleus Developing CNS and PNS at embryonic and postnatal stages. Expressed in the epithelium of glandular stomach (PubMed:18173746). Between 8.5 dpc and 10.5 dpc it is found in the neuroepithelium of the midbrain and ventral forebrain, as well as in the spinal cord. Between 10.5 dpc and 12.5 dpc its expression pattern changes from a restricted to a widespread zone, it is then found at variable levels in the ventricular zone in all regions of the brain, where is expressed in a subset of p2 progenitors that can give rise to either V2a or V2b interneuron subtypes. From 12.5 dpc to postnatal stages it is also expressed in cells outside of the ventricular zone through the brain, and in addition it is also expressed during development of the olfactory epithelium and neural retina. At 12.5 dpc, it is highly expressed by differentiating enteric neurons in the mesenchyme of the stomach. At 14.5 and 16.5 dpc, it is also expressed in the epithelium of the glandular stomach (PubMed:18173746). Lethality at birth caused by severe defects in neurogenesis. While the brain and spinal cord of the mutants appear normal, their olfactory epithelium and sympathetic, parasympathetic and enteric ganglia are severely affected. In the olfactory epithelium, neuronal progenitors die at an early stage, whereas the non-neuronal supporting cells are present. In sympathetic ganglia, the development of neuronal precursors is arrested, preventing the generation of sympathetic neurons, without affecting glial precursor cells. Homozygous MASH1-null mice have smaller stomachs than the control, and neuroendocrine cells are mostly missing, while chief, parietal and pit cells are formed. However, the wall of the glandular stomach is much thicker, has a deeper fold structure, and the forestomach epithelium is villous compared to controls (PubMed:18173746). negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding neuron migration noradrenergic neuron development noradrenergic neuron fate commitment DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription from RNA polymerase II promoter Notch signaling pathway multicellular organism development regulation of mitotic cell cycle pattern specification process nervous system development neuroblast fate determination neuroblast proliferation sensory organ development heart development transcription factor binding regulation of Notch signaling pathway glial cell differentiation response to lithium ion regulation of gene expression oligodendrocyte development spinal cord association neuron differentiation spinal cord oligodendrocyte cell differentiation spinal cord oligodendrocyte cell fate specification vestibular nucleus development oligodendrocyte cell fate commitment forebrain neuron differentiation cerebral cortex GABAergic interneuron differentiation commitment of neuronal cell to specific neuron type in forebrain central nervous system neuron development cerebral cortex development neurogenesis cell differentiation neuron differentiation regulation of epithelial cell differentiation response to retinoic acid regulation of cell proliferation protein homodimerization activity neuronal cell body negative regulation of apoptotic process bHLH transcription factor binding positive regulation of neuron apoptotic process sequence-specific DNA binding negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of Notch signaling pathway positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity cell maturation enteric nervous system development sympathetic nervous system development parasympathetic nervous system development neuron fate commitment neuron fate specification neuron development generation of neurons oligodendrocyte differentiation regulation of neurogenesis positive regulation of neurogenesis musculoskeletal movement, spinal reflex action response to folic acid subpallium neuron fate commitment regulation of timing of subpallium neuron differentiation olfactory pit development ventral spinal cord interneuron fate commitment lung neuroendocrine cell differentiation stomach neuroendocrine cell differentiation carotid body glomus cell differentiation adrenal chromaffin cell differentiation sympathetic ganglion development response to epidermal growth factor E-box binding cellular response to magnetism RNA polymerase II transcription factor complex positive regulation of neural precursor cell proliferation uc007gqs.1 uc007gqs.2 uc007gqs.3 
ENSMUST00000020248.16 Washc3 ENSMUST00000020248.16 WASH complex subunit 3, transcript variant 1 (from RefSeq NM_026070.3) Ccdc53 ENSMUST00000020248.1 ENSMUST00000020248.10 ENSMUST00000020248.11 ENSMUST00000020248.12 ENSMUST00000020248.13 ENSMUST00000020248.14 ENSMUST00000020248.15 ENSMUST00000020248.2 ENSMUST00000020248.3 ENSMUST00000020248.4 ENSMUST00000020248.5 ENSMUST00000020248.6 ENSMUST00000020248.7 ENSMUST00000020248.8 ENSMUST00000020248.9 NM_026070 Q8K2X5 Q9CR27 Q9D0Y7 WASC3_MOUSE Washc3 uc007grh.1 uc007grh.2 uc007grh.3 uc007grh.4 Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sortingg. Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. The WASH core complex associates via WASHC2 with the F- actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex. Early endosome Belongs to the CCDC53 family. molecular_function endosome early endosome exocytosis protein transport actin filament polymerization WASH complex uc007grh.1 uc007grh.2 uc007grh.3 uc007grh.4 
ENSMUST00000020249.2 Dram1 ENSMUST00000020249.2 DNA-damage regulated autophagy modulator 1, transcript variant 3 (from RefSeq NR_184639.1) DRAM1_MOUSE Dram ENSMUST00000020249.1 NR_184639 Q78J26 Q9DC58 uc007grj.1 uc007grj.2 Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy (By similarity). Lysosome membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DC58-1; Sequence=Displayed; Name=2; IsoId=Q9DC58-2; Sequence=VSP_025461; Belongs to the DRAM/TMEM150 family. molecular_function cytoplasm lysosome lysosomal membrane autophagy apoptotic process regulation of autophagy membrane integral component of membrane uc007grj.1 uc007grj.2 
ENSMUST00000020251.10 Gnptab ENSMUST00000020251.10 N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits, transcript variant 5 (from RefSeq NM_001421319.1) ENSMUST00000020251.1 ENSMUST00000020251.2 ENSMUST00000020251.3 ENSMUST00000020251.4 ENSMUST00000020251.5 ENSMUST00000020251.6 ENSMUST00000020251.7 ENSMUST00000020251.8 ENSMUST00000020251.9 GNPTA_MOUSE Gnpta Kiaa1208 NM_001421319 Q3U3K6 Q3US34 Q69ZN6 uc007grl.1 uc007grl.2 uc007grl.3 Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. Reaction=N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L- asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl- (1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP; Xref=Rhea:RHEA:13581, Rhea:RHEA-COMP:14507, Rhea:RHEA-COMP:14508, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:57865, ChEBI:CHEBI:140357, ChEBI:CHEBI:140369; EC=2.7.8.17; Evidence=; Hexamer of two alpha, two beta and two gamma (GNPTG) subunits; disulfide-linked. The alpha and/or the beta subunits of the enzyme constitute the catalytic subunits. Interacts with LYSET; facilitates proper localization of GNPTAB. [N-acetylglucosamine-1-phosphotransferase subunit alpha]: Golgi apparatus membrane ; Single-pass type I membrane protein [N-acetylglucosamine-1-phosphotransferase subunit beta]: Golgi apparatus membrane ; Single- pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69ZN6-1; Sequence=Displayed; Name=2; IsoId=Q69ZN6-2; Sequence=VSP_017340, VSP_017341; The DMAP1-binding domain mediates substrate recognition. It specifically recognizes a conformation-dependent protein determinant present in acid hydrolases. The alpha- and beta-subunits are generated by a proteolytic cleavage by MBTPS1 protease at the Lys-907-Asp-908 bond. Severe retinal degeneration, growth retardation and secretory cell lesions. Mice are smaller with a reduced mean body weight and length, along with a reduction in total tissue mass and lean body mass. They show elevated levels of serum lysosomal enzymes, cartilage defects, and display cytoplasmic alterations in secretory cells of several exocrine glands. Stealth proteins are part of a protein family that is conserved from bacteria to higher eukaryotes. Family members were first identified in microbes as proteins that help pathogens to elude the host innate immune system. Microbial stealth proteins are most likely involved in the biosynthesis of exopolysaccharides. Stealth proteins are predicted to function as hexose-1-phosphoryltransferases. Belongs to the stealth family. Sequence=BAD32410.1; Type=Erroneous initiation; Evidence=; Sequence=BAE32779.1; Type=Erroneous initiation; Evidence=; Golgi membrane UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity calcium ion binding Golgi apparatus lysosome organization protein secretion membrane integral component of membrane N-glycan processing to lysosome transferase activity transferase activity, transferring phosphorus-containing groups secretion of lysosomal enzymes carbohydrate phosphorylation metal ion binding uc007grl.1 uc007grl.2 uc007grl.3 
ENSMUST00000020252.10 Sycp3 ENSMUST00000020252.10 synaptonemal complex protein 3 (from RefSeq NM_011517.2) A2RSE7 A2RSE7_MOUSE ENSMUST00000020252.1 ENSMUST00000020252.2 ENSMUST00000020252.3 ENSMUST00000020252.4 ENSMUST00000020252.5 ENSMUST00000020252.6 ENSMUST00000020252.7 ENSMUST00000020252.8 ENSMUST00000020252.9 NM_011517 Sycp3 uc007grm.1 uc007grm.2 uc007grm.3 uc007grm.4 Belongs to the XLR/SYCP3 family. lateral element uc007grm.1 uc007grm.2 uc007grm.3 uc007grm.4 
ENSMUST00000020255.8 Slc5a8 ENSMUST00000020255.8 solute carrier family 5 (iodide transporter), member 8 (from RefSeq NM_145423.2) ENSMUST00000020255.1 ENSMUST00000020255.2 ENSMUST00000020255.3 ENSMUST00000020255.4 ENSMUST00000020255.5 ENSMUST00000020255.6 ENSMUST00000020255.7 NM_145423 Q8BYF6 Q8VD01 SC5A8_MOUSE Slc5a8 Smct Smct1 uc007grz.1 uc007grz.2 Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)- dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D- lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5- aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1 (PubMed:15322102, PubMed:15651982, PubMed:20211600). Catalyzes passive carrier mediated diffusion of iodide (By similarity). Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (By similarity). May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract (By similarity). May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons (By similarity). Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) (PubMed:20211600). Can mediate the transport of chloride, bromide, iodide and nitrate ions when external concentration of sodium ions is reduced (By similarity). Reaction=(S)-lactate(out) + 2 Na(+)(out) = (S)-lactate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72935, ChEBI:CHEBI:16651, ChEBI:CHEBI:29101; Evidence=; Reaction=2 Na(+)(out) + propanoate(out) = 2 Na(+)(in) + propanoate(in); Xref=Rhea:RHEA:72939, ChEBI:CHEBI:17272, ChEBI:CHEBI:29101; Evidence=; Reaction=2 Na(+)(out) + pyruvate(out) = 2 Na(+)(in) + pyruvate(in); Xref=Rhea:RHEA:72943, ChEBI:CHEBI:15361, ChEBI:CHEBI:29101; Evidence=; Reaction=acetate(out) + 2 Na(+)(out) = acetate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72947, ChEBI:CHEBI:29101, ChEBI:CHEBI:30089; Evidence=; Reaction=butanoate(out) + 2 Na(+)(out) = butanoate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72951, ChEBI:CHEBI:17968, ChEBI:CHEBI:29101; Evidence=; Reaction=2 Na(+)(out) + nicotinate(out) = 2 Na(+)(in) + nicotinate(in); Xref=Rhea:RHEA:72955, ChEBI:CHEBI:29101, ChEBI:CHEBI:32544; Evidence=; Reaction=(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) = (R)-3- hydroxybutanoate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72959, ChEBI:CHEBI:10983, ChEBI:CHEBI:29101; Evidence=; Reaction=acetoacetate(out) + 2 Na(+)(out) = acetoacetate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72963, ChEBI:CHEBI:13705, ChEBI:CHEBI:29101; Evidence=; Reaction=4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) = 4-methyl-2- oxopentanoate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72967, ChEBI:CHEBI:17865, ChEBI:CHEBI:29101; Evidence=; Reaction=5-oxo-L-proline(out) + 2 Na(+)(out) = 5-oxo-L-proline(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72971, ChEBI:CHEBI:29101, ChEBI:CHEBI:58402; Evidence=; Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324, ChEBI:CHEBI:16382; Evidence=; Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; Reaction=nitrate(in) = nitrate(out); Xref=Rhea:RHEA:34923, ChEBI:CHEBI:17632; Evidence=; Reaction=bromide(in) = bromide(out); Xref=Rhea:RHEA:75383, ChEBI:CHEBI:15858; Evidence=; Transport of D-lactate and pyruvate stimulated by alpha-cyano-4-hydroxycinnamic acid, but inhibited by the short-chain fatty acids acetate, propionate and butyrate. Kinetic parameters: KM=296 uM for nicotinate ; Interacts (via PDZ-binding motif) with PDZK1 (via PDZ domains 1 and 3); interaction increases nicotinate transport activity of SLC5A8. Apical cell membrane ulti-pass membrane protein Note=Restricted to the apical cell membrane of enterocytes. Expressed in brain, colon, kidney and in the ileum and jejunum of small intestine. In the kidney, expression occurred in the proximal tubule and the loop of Henle, being restricted to tubular epithelial cells in both the cortex and the medulla. In the colon, predominantly expressed in the distal half of the large bowel and in the most terminal ileum. Localized selectively in the luminal surface of crypts in the large intestine and to the brush border in the middle parts of crypts in the cecum. In the brain, expression was seen throughout, exclusively in neurons, including the cortex, hippocampus, cerebellum and pituitary gland (at protein level). Expression is reduced in oligodendrogliomas. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. Sequence=AAH17691.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; organic acid:sodium symporter activity plasma membrane ion transport sodium ion transport apoptotic process lactate transmembrane transporter activity symporter activity propionate transmembrane transporter activity short-chain fatty acid uptake transporter activity monocarboxylic acid transport propanoate transport short-chain fatty acid import membrane integral component of membrane apical plasma membrane transmembrane transporter activity brush border membrane lactate transmembrane transport transmembrane transport organic acid transmembrane transport uc007grz.1 uc007grz.2 
ENSMUST00000020258.10 Herc4 ENSMUST00000020258.10 hect domain and RLD 4, transcript variant 2 (from RefSeq NM_026101.4) ENSMUST00000020258.1 ENSMUST00000020258.2 ENSMUST00000020258.3 ENSMUST00000020258.4 ENSMUST00000020258.5 ENSMUST00000020258.6 ENSMUST00000020258.7 ENSMUST00000020258.8 ENSMUST00000020258.9 HERC4_MOUSE NM_026101 Q3UL34 Q3UPX2 Q6PAV2 Q810A0 Q811C9 Q8R315 Q9D797 uc007fkc.1 uc007fkc.2 uc007fkc.3 uc007fkc.4 Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Protein modification; protein ubiquitination. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PAV2-1; Sequence=Displayed; Name=2; IsoId=Q6PAV2-2; Sequence=VSP_023182; Name=3; IsoId=Q6PAV2-3; Sequence=VSP_023180, VSP_023181; Ubiquitously expressed, highest expression is found in testis during spermiogenesis. It is specifically found in spermatogonia, spermatocytes, and spermatids with little or no expression detectable in the spermatozoa, or interstitial cells. Highly expressed in testis during spermiogenesis. Expression was almost undetectable in testes at postnatal day 14 (P14). However, by P23, a strong increase in mRNA levels was observed with expression persisting to P40 when spermatozoa were first observed. Up- regulated in the uterine luminal epithelium at the time of embryo implantation. Disruption causes defects in spermatozoon maturation and impaired fertility in males; females display normal fertility. Males produce litter sizes some 50% smaller, as well 50% of mature spermatozoa have reduced mobility. T.wilfordii induces abnormal expression of spermiogenesis genes including Herc4, the spermatogenic cells in the convoluted seminiferous tubules decrease and the lumen is obstructed by large deciduous spermatogenic cells. T.wilfordii has apparent antifertility effects. fibrillar center ubiquitin-protein transferase activity cytoplasm cytosol spermatogenesis protein ubiquitination transferase activity cell differentiation ubiquitin protein ligase activity uc007fkc.1 uc007fkc.2 uc007fkc.3 uc007fkc.4 
ENSMUST00000020262.5 Pbld2 ENSMUST00000020262.5 phenazine biosynthesis-like protein domain containing 2, transcript variant 6 (from RefSeq NR_175966.1) ENSMUST00000020262.1 ENSMUST00000020262.2 ENSMUST00000020262.3 ENSMUST00000020262.4 Mawbp1 NR_175966 PBLD2_MOUSE Q9CXN7 Q9D2W4 uc007fjr.1 uc007fjr.2 uc007fjr.3 Belongs to the PhzF family. molecular_function catalytic activity biological_process biosynthetic process isomerase activity uc007fjr.1 uc007fjr.2 uc007fjr.3 
ENSMUST00000020263.14 Hnrnph3 ENSMUST00000020263.14 heterogeneous nuclear ribonucleoprotein H3, transcript variant 4 (from RefSeq NM_001359261.1) D3Z3N4 D3Z3N4_MOUSE ENSMUST00000020263.1 ENSMUST00000020263.10 ENSMUST00000020263.11 ENSMUST00000020263.12 ENSMUST00000020263.13 ENSMUST00000020263.2 ENSMUST00000020263.3 ENSMUST00000020263.4 ENSMUST00000020263.5 ENSMUST00000020263.6 ENSMUST00000020263.7 ENSMUST00000020263.8 ENSMUST00000020263.9 Hnrnph3 NM_001359261 uc007fjo.1 uc007fjo.2 uc007fjo.3 nucleic acid binding RNA binding nucleus nucleoplasm biological_process epithelial cell differentiation uc007fjo.1 uc007fjo.2 uc007fjo.3 
ENSMUST00000020268.7 Ccar1 ENSMUST00000020268.7 Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the retinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (By similarity). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). (from UniProt Q8CH18) BC079652 CCAR1_MOUSE Carp1 ENSMUST00000020268.1 ENSMUST00000020268.2 ENSMUST00000020268.3 ENSMUST00000020268.4 ENSMUST00000020268.5 ENSMUST00000020268.6 Q05BR1 Q05DK6 Q6AXC9 Q6PAR2 Q80XE4 Q8BJY0 Q8BVN2 Q8CGG1 Q8CH18 Q9CSR5 uc007fjb.1 uc007fjb.2 uc007fjb.3 Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the retinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (By similarity). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). Directly interacts with ESR1, NR3C1 and p53/TP53. Interacts (via N-terminus) with CALCOCO1. Interacts with MED1 and GATA1. Interacts with AR and GATA2 (By similarity). Cytoplasm, perinuclear region Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CH18-1; Sequence=Displayed; Name=2; IsoId=Q8CH18-2; Sequence=VSP_018054, VSP_018055; Name=3; IsoId=Q8CH18-3; Sequence=VSP_037737; Sequence=AAH10199.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH34174.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH39939.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH51052.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH60130.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH79652.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; RNA polymerase II distal enhancer sequence-specific DNA binding transcription coactivator activity transcription corepressor activity protein binding nucleus nuclear envelope lumen cytoplasm regulation of transcription, DNA-templated apoptotic process cell cycle positive regulation of cell proliferation positive regulation of cell migration ligand-dependent nuclear receptor transcription coactivator activity positive regulation of apoptotic process perinuclear region of cytoplasm negative regulation of nucleic acid-templated transcription positive regulation of nucleic acid-templated transcription uc007fjb.1 uc007fjb.2 uc007fjb.3 
ENSMUST00000020270.6 Ddx50 ENSMUST00000020270.6 DExD box helicase 50, transcript variant 1 (from RefSeq NM_053183.3) DDX50_MOUSE ENSMUST00000020270.1 ENSMUST00000020270.2 ENSMUST00000020270.3 ENSMUST00000020270.4 ENSMUST00000020270.5 NM_053183 Q99MJ9 uc007fhp.1 uc007fhp.2 uc007fhp.3 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Interacts with C1QBP. Nucleus, nucleolus Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus nucleolus plasma membrane hydrolase activity uc007fhp.1 uc007fhp.2 uc007fhp.3 
ENSMUST00000020273.16 Supv3l1 ENSMUST00000020273.16 suppressor of var1, 3-like 1 (S. cerevisiae), transcript variant 1 (from RefSeq NM_181423.3) ENSMUST00000020273.1 ENSMUST00000020273.10 ENSMUST00000020273.11 ENSMUST00000020273.12 ENSMUST00000020273.13 ENSMUST00000020273.14 ENSMUST00000020273.15 ENSMUST00000020273.2 ENSMUST00000020273.3 ENSMUST00000020273.4 ENSMUST00000020273.5 ENSMUST00000020273.6 ENSMUST00000020273.7 ENSMUST00000020273.8 ENSMUST00000020273.9 NM_181423 Q50HX5 Q80YD1 SUV3_MOUSE Suv3l1 uc007fhd.1 uc007fhd.2 uc007fhd.3 Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (By similarity). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Helicase activity toward DNA substrate is inhibited by micromolar concentrations of 5,6-dichloro-1-(beta-D- ribofuranosyl)benzotriazole (DRBT) and 4,5,6,7-tetrabromobenzotriazole (TBBT). Helicase activity toward RNA substrate is inhibited by elevated concentrations of TBBT. Inhibited by some ring-expanded nucleoside analogs. Homodimer; in free form. Component of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer containing 2 copies of SUPV3L1 and 3 copies of PNPT1. As part of mitochondrial degradosome complex, interacts with GRSF1 in a RNA-dependent manner; the interaction enhances the activity of the complex. Interacts with LAMTOR5/HBXIP, WRN and BLM. Nucleus Mitochondrion matrix Mitochondrion matrix, mitochondrion nucleoid Die in utero before midgestation. Show elevated sister chromatid exchange (SCE). Belongs to the helicase family. nucleotide binding mitochondrial mRNA catabolic process positive regulation of mitochondrial RNA catabolic process mitochondrial RNA 3'-end processing DNA binding DNA helicase activity RNA helicase activity double-stranded RNA binding helicase activity ATP binding nucleus mitochondrion mitochondrial matrix DNA recombination RNA catabolic process hydrolase activity hydrolase activity, acting on acid anhydrides positive regulation of cell growth DNA duplex unwinding 3'-5' RNA helicase activity mitochondrial ncRNA surveillance mitochondrial mRNA surveillance mitochondrial nucleoid protein homodimerization activity negative regulation of apoptotic process mitochondrial degradosome mitochondrion morphogenesis chromatin maintenance mitochondrial RNA surveillance uc007fhd.1 uc007fhd.2 uc007fhd.3 
ENSMUST00000020277.9 Hkdc1 ENSMUST00000020277.9 hexokinase domain containing 1 (from RefSeq NM_145419.1) ENSMUST00000020277.1 ENSMUST00000020277.2 ENSMUST00000020277.3 ENSMUST00000020277.4 ENSMUST00000020277.5 ENSMUST00000020277.6 ENSMUST00000020277.7 ENSMUST00000020277.8 HKDC1_MOUSE Hkdc1 NM_145419 Q3UKJ9 Q91W97 uc007fhc.1 uc007fhc.2 uc007fhc.3 Catalyzes the phosphorylation of hexose to hexose 6- phosphate, although at very low level compared to other hexokinases (By similarity). Has low glucose phosphorylating activity compared to other hexokinases (By similarity). Involved in glucose homeostasis and hepatic lipid accumulation (PubMed:30543855). Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (PubMed:25648650, PubMed:27459389). Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+); Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741; Evidence=; Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+); Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826; Evidence=; Carbohydrate metabolism; hexose metabolism. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 1/4. Cytoplasm Mitochondrion membrane ; Peripheral membrane protein Photoreceptor inner segment Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrion. Widely expressed. Detected in retina, brain, cerebellum, liver, lung, kidney, spleen, pancreas and intestine (PubMed:30085091). Embryonic lethality. Belongs to the hexokinase family. nucleotide binding cellular glucose homeostasis glucokinase activity hexokinase activity ATP binding glucose binding mitochondrion cytosol carbohydrate metabolic process glycolytic process fructokinase activity membrane kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor mannokinase activity hexose metabolic process mitochondrial membrane carbohydrate phosphorylation glucose 6-phosphate metabolic process uc007fhc.1 uc007fhc.2 uc007fhc.3 
ENSMUST00000020278.6 Tacr2 ENSMUST00000020278.6 tachykinin receptor 2 (from RefSeq NM_009314.4) ENSMUST00000020278.1 ENSMUST00000020278.2 ENSMUST00000020278.3 ENSMUST00000020278.4 ENSMUST00000020278.5 NM_009314 Q3KP20 Q3KP20_MOUSE Tacr2 uc007fgx.1 uc007fgx.2 uc007fgx.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity tachykinin receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway tachykinin receptor signaling pathway positive regulation of acetylcholine secretion, neurotransmission intestine smooth muscle contraction membrane integral component of membrane substance K receptor activity negative regulation of luteinizing hormone secretion operant conditioning sperm flagellum positive regulation of vascular permeability positive regulation of ion transport response to electrical stimulus prolactin secretion positive regulation of uterine smooth muscle contraction sperm midpiece positive regulation of flagellated sperm motility uc007fgx.1 uc007fgx.2 uc007fgx.3 
ENSMUST00000020283.5 Macroh2a2 ENSMUST00000020283.5 macroH2A.2 histone (from RefSeq NM_207000.2) A0JP36 ENSMUST00000020283.1 ENSMUST00000020283.2 ENSMUST00000020283.3 ENSMUST00000020283.4 H2AW_MOUSE H2afy2 H2afy3 Macroh2a2 NM_207000 Q3TNT4 Q8CCK0 Q925I6 uc007fgm.1 uc007fgm.2 uc007fgm.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Nov 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF336305.1, AK032636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein replication-independent histone :: PMID: 25731851 ##RefSeq-Attributes-END## Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. Nucleus Chromosome Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin. Present in liver, kidney and adrenal gland (at protein level). In the liver, present in cells of the bile ducts and parenchymal cells, but not in hepatocytes. In the kidney, present in proximal and distal convoluted tubules and in glomeruli. Present at highest levels in the parietal layer of Bowman capsule. In the adrenal gland, present in the outer cells of the capsule. negative regulation of transcription from RNA polymerase II promoter chromatin nucleosome nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding Barr body DNA binding nucleus nucleoplasm chromosome chromatin organization nucleosome assembly brain development dosage compensation chromatin DNA binding transcription regulatory region DNA binding positive regulation of keratinocyte differentiation negative regulation of gene expression, epigenetic protein heterodimerization activity establishment of protein localization to chromatin negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter uc007fgm.1 uc007fgm.2 uc007fgm.3 
ENSMUST00000020284.5 Tysnd1 ENSMUST00000020284.5 trypsin domain containing 1, transcript variant 1 (from RefSeq NM_027912.1) ENSMUST00000020284.1 ENSMUST00000020284.2 ENSMUST00000020284.3 ENSMUST00000020284.4 NM_027912 Q0VE90 Q9DBA6 TYSD1_MOUSE uc007fgh.1 uc007fgh.2 uc007fgh.3 This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]. Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids (By similarity). Inhibited by N-ethylmaleimide (NEM). Not affected by leupeptin or trans-epoxysuccinyl-l-leucylamido-(4-gianidino) butane (E64). Homodimer. Forms a heterodimer with the C-terminal cleavage product (49 kDa form). Forms a heterodimer with the N-terminal cleavage product (10 kDa form). Interacts with PEX5. Interacts with LONP2. Peroxisome By the proliferator-activated receptor alpha agonist bezafibrate. Self-cleavage gives rise to an N-terminal 10-kDa fragment and C- terminal 49-kDa fragment upon import into the peroxisomes. The full- lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity. Belongs to the peptidase S1B family. protease binding serine-type endopeptidase activity peroxisome peroxisomal matrix proteolysis peptidase activity serine-type peptidase activity protein processing hydrolase activity regulation of fatty acid beta-oxidation identical protein binding protein homooligomerization uc007fgh.1 uc007fgh.2 uc007fgh.3 
ENSMUST00000020285.10 Sar1a ENSMUST00000020285.10 secretion associated Ras related GTPase 1A, transcript variant 1 (from RefSeq NM_009120.4) ENSMUST00000020285.1 ENSMUST00000020285.2 ENSMUST00000020285.3 ENSMUST00000020285.4 ENSMUST00000020285.5 ENSMUST00000020285.6 ENSMUST00000020285.7 ENSMUST00000020285.8 ENSMUST00000020285.9 NM_009120 Q99JZ4 Q99JZ4_MOUSE Sar1a Sara1 uc007fgg.1 uc007fgg.2 uc007fgg.3 Interacts with B3GAT1. Belongs to the small GTPase superfamily. SAR1 family. Golgi membrane nucleotide binding GTP binding endoplasmic reticulum Golgi apparatus intracellular protein transport protein transport vesicle-mediated transport COPII vesicle coat cargo loading into COPII-coated vesicle uc007fgg.1 uc007fgg.2 uc007fgg.3 
ENSMUST00000020286.7 Ppa1 ENSMUST00000020286.7 pyrophosphatase (inorganic) 1 (from RefSeq NM_026438.4) ENSMUST00000020286.1 ENSMUST00000020286.2 ENSMUST00000020286.3 ENSMUST00000020286.4 ENSMUST00000020286.5 ENSMUST00000020286.6 IPYR_MOUSE NM_026438 Pp Pyp Q9D819 uc007fge.1 uc007fge.2 uc007fge.3 Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474; EC=3.6.1.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Homodimer. Cytoplasm Belongs to the PPase family. magnesium ion binding inorganic diphosphatase activity cytoplasm phosphate-containing compound metabolic process pyrophosphatase activity hydrolase activity metal ion binding uc007fge.1 uc007fge.2 uc007fge.3 
ENSMUST00000020287.8 Npffr1 ENSMUST00000020287.8 neuropeptide FF receptor 1 (from RefSeq NM_001177511.2) E9Q468 E9Q468_MOUSE ENSMUST00000020287.1 ENSMUST00000020287.2 ENSMUST00000020287.3 ENSMUST00000020287.4 ENSMUST00000020287.5 ENSMUST00000020287.6 ENSMUST00000020287.7 NM_001177511 Npffr1 uc007fgd.1 uc007fgd.2 uc007fgd.3 uc007fgd.4 Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity integral component of plasma membrane cilium signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway neuropeptide receptor activity membrane integral component of membrane cellular response to hormone stimulus uc007fgd.1 uc007fgd.2 uc007fgd.3 uc007fgd.4 
ENSMUST00000020288.15 Eif4ebp2 ENSMUST00000020288.15 eukaryotic translation initiation factor 4E binding protein 2 (from RefSeq NM_010124.2) ENSMUST00000020288.1 ENSMUST00000020288.10 ENSMUST00000020288.11 ENSMUST00000020288.12 ENSMUST00000020288.13 ENSMUST00000020288.14 ENSMUST00000020288.2 ENSMUST00000020288.3 ENSMUST00000020288.4 ENSMUST00000020288.5 ENSMUST00000020288.6 ENSMUST00000020288.7 ENSMUST00000020288.8 ENSMUST00000020288.9 Eif4ebp2 NM_010124 Q3UFP6 Q3UFP6_MOUSE uc007fga.1 uc007fga.2 uc007fga.3 Belongs to the eIF4E-binding protein family. eukaryotic initiation factor 4E binding negative regulation of translational initiation postsynapse uc007fga.1 uc007fga.2 uc007fga.3 
ENSMUST00000020289.10 Pald1 ENSMUST00000020289.10 phosphatase domain containing, paladin 1, transcript variant 1 (from RefSeq NM_013753.2) A0A0R4J007 A0A0R4J007_MOUSE ENSMUST00000020289.1 ENSMUST00000020289.2 ENSMUST00000020289.3 ENSMUST00000020289.4 ENSMUST00000020289.5 ENSMUST00000020289.6 ENSMUST00000020289.7 ENSMUST00000020289.8 ENSMUST00000020289.9 NM_013753 Pald1 uc007ffx.1 uc007ffx.2 uc007ffx.3 uc007ffx.4 Cytoplasm, cytosol Belongs to the paladin family. cytosol uc007ffx.1 uc007ffx.2 uc007ffx.3 uc007ffx.4 
ENSMUST00000020298.8 Pcbd1 ENSMUST00000020298.8 pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 (from RefSeq NM_025273.4) Dcoh ENSMUST00000020298.1 ENSMUST00000020298.2 ENSMUST00000020298.3 ENSMUST00000020298.4 ENSMUST00000020298.5 ENSMUST00000020298.6 ENSMUST00000020298.7 NM_025273 P61458 P70519 P80095 PHS_MOUSE Pcbd Q9D930 uc007ffj.1 uc007ffj.2 uc007ffj.3 uc007ffj.4 uc007ffj.5 This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. [provided by RefSeq, Apr 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK007401.1, BY707492.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## multifunctional gene product(s) :: PMID: 12011081 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Also acts as a coactivator for HNF1B-dependent transcription (By similarity). Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920, ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96; Evidence=; Homotetramer and homodimer. Heterotetramer with HNF1A; formed by a dimer of dimers (By similarity). Interacts with HNF1B (via HNF-p1 domain); the interaction increases HNF1B transactivation activity (By similarity). Cytoplasm Nucleus Note=Recruited to the nucleus through the interaction with HNF1B. Mainly expressed in the liver, in pancreatic cells, and in the kidney, especially in the distal convoluted tubule, in the cortical thick ascending limb of Henle's loop and in the connecting tubule. Up-regulated by a low magnesium-containing diet. Belongs to the pterin-4-alpha-carbinolamine dehydratase family. transcription coactivator activity phenylalanine 4-monooxygenase activity protein binding nucleus nucleoplasm cytoplasm cytosol L-phenylalanine metabolic process tetrahydrobiopterin biosynthetic process 4-alpha-hydroxytetrahydrobiopterin dehydratase activity lyase activity identical protein binding regulation of protein binding regulation of protein homodimerization activity positive regulation of transcription, DNA-templated oxidation-reduction process uc007ffj.1 uc007ffj.2 uc007ffj.3 uc007ffj.4 uc007ffj.5 
ENSMUST00000020301.14 Vsir ENSMUST00000020301.14 V-set immunoregulatory receptor, transcript variant 1 (from RefSeq NM_028732.4) A0A171EBK7 A0A171EBK7_MOUSE ENSMUST00000020301.1 ENSMUST00000020301.10 ENSMUST00000020301.11 ENSMUST00000020301.12 ENSMUST00000020301.13 ENSMUST00000020301.2 ENSMUST00000020301.3 ENSMUST00000020301.4 ENSMUST00000020301.5 ENSMUST00000020301.6 ENSMUST00000020301.7 ENSMUST00000020301.8 ENSMUST00000020301.9 NM_028732 Vsir uc007few.1 uc007few.2 uc007few.3 plasma membrane positive regulation of gene expression positive regulation of endopeptidase activity membrane integral component of membrane enzyme binding positive regulation of cell migration zymogen activation negative regulation of interferon-gamma production negative regulation of interleukin-10 production negative regulation of interleukin-17 production negative regulation of tumor necrosis factor production identical protein binding positive regulation of regulatory T cell differentiation regulation of immune response endopeptidase activator activity negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of CD8-positive, alpha-beta T cell proliferation uc007few.1 uc007few.2 uc007few.3 
ENSMUST00000020308.5 Ddit4 ENSMUST00000020308.5 DNA-damage-inducible transcript 4 (from RefSeq NM_029083.2) DDIT4_MOUSE Dig2 ENSMUST00000020308.1 ENSMUST00000020308.2 ENSMUST00000020308.3 ENSMUST00000020308.4 NM_029083 Q9D3F7 Redd1 Rtp801 uc007fee.1 uc007fee.2 uc007fee.3 Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes. Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. Required for mTORC1-mediated defense against viral protein synthesis and virus replication. Monomer. Interacts with BTRC. Identified in a complex with CUL4A, DDB1 and BTRC. Interacts with TXNIP; this inhibits the proteasomal degradation of DDIT4 (By similarity). Mitochondrion Cytoplasm, cytosol Ubiquitously expressed. Expressed at 7 dpc. At 11 dpc, expressed in the apical ectodermal ridge. At 13.5 dpc, expressed in the whisker pad, eyelid, breast primordia and developing limb. At 14.5 dpc, expressed in supraorbital and suborbital follicles, whisker pad, limbs and patches of developing epidermis. By dexamethasone, heat-shock or osmotic stress. Up-regulated by hypoxia, in a HIF1A-dependent but TP53-independent mechanism. Up- regulated upon energy stress. Up-regulated in brain from MPTP- intoxicated mice, a model for Parkinson disease (at protein level). Up- regulated by hypoxia in bowel, liver, spleen, heart, lung, brain and kidney. Phosphorylated by GSK3B; this promotes proteasomal degradation. Polyubiquitinated by a DCX (DDB1-CUL4A-RBX1) E3 ubiquitin-protein ligase complex with BTRC as substrate-recognition component, leading to its proteasomal degradation. No visible phenotype. Mice are normal and less sensitive to oxygen-induced retinopathy. Mitochondria show increased production of reactive oxygen species. Newborn mice show increased radiation-induced apoptosis in brain and thymus, due to increased levels of TP53 and increased TP53 activity. Likewise, cultured embryonic fibroblasts are highly sensitive to DNA damage caused by UV irradiation or doxomycin and display increased levels of TP53 and increased TP53 activity, leading to increased apoptosis. Cultured embryonic fibroblasts are more susceptible to cell death caused by influenza virus infection and produce about 200 times more virus particles than wild-type. Belongs to the DDIT4 family. response to hypoxia neuron migration cytoplasm mitochondrion cytosol apoptotic process brain development cell proliferation negative regulation of signal transduction negative regulation of peptidyl-threonine phosphorylation neuron differentiation regulation of TOR signaling negative regulation of TOR signaling macromolecular complex disassembly negative regulation of peptidyl-serine phosphorylation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of glycolytic process neurotrophin TRK receptor signaling pathway defense response to virus cellular response to dexamethasone stimulus 14-3-3 protein binding reactive oxygen species metabolic process positive regulation of neuron death negative regulation of intracellular signal transduction uc007fee.1 uc007fee.2 uc007fee.3 
ENSMUST00000020312.13 Mcu ENSMUST00000020312.13 mitochondrial calcium uniporter (from RefSeq NM_001033259.4) B2RTD1 ENSMUST00000020312.1 ENSMUST00000020312.10 ENSMUST00000020312.11 ENSMUST00000020312.12 ENSMUST00000020312.2 ENSMUST00000020312.3 ENSMUST00000020312.4 ENSMUST00000020312.5 ENSMUST00000020312.6 ENSMUST00000020312.7 ENSMUST00000020312.8 ENSMUST00000020312.9 MCU_MOUSE Mcu NM_001033259 Q3TTK3 Q3UMR5 uc007fdt.1 uc007fdt.2 uc007fdt.3 uc007fdt.4 Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685886, PubMed:23900286, PubMed:24212091). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (By similarity). Activity is regulated by MICU1 and MICU2 (By similarity). At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity). Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (By similarity). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:26119742, PubMed:26119731, PubMed:25603276). Participates in mitochondrial permeability transition during ischemia-reperfusion injury (PubMed:26119731). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (By similarity). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (PubMed:25732818). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (PubMed:26644474). Involved in antigen processing and presentation (PubMed:25251370). Inhibited by ruthenium red or its derivative Ru360. Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1 (By similarity). Heterooligomer with CCDC109B/MCUB; this inhibits channel activity (PubMed:23900286). Homooligomer. Homotetramer (PubMed:23900286). Interacts with MICU1; MICU1 acts as an essential regulator for MCU. Interacts with MCUR1. Interactions with MICU1 and MCUR1 are mutually exclusive. Interacts with MICU2 (By similarity). Interacts with SLC25A23 (By similarity). Q3UMR5; Q810S1: Mcub; NbExp=3; IntAct=EBI-776370, EBI-8847756; Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UMR5-1; Sequence=Displayed; Name=2; IsoId=Q3UMR5-2; Sequence=VSP_024264, VSP_024265; Detected in heart muscle (at protein level) (PubMed:26057074). Expressed in skeletal muscle, heart, kidney, liver, brain, lung, white fat and spleen. The N-terminal domain is required for efficient Ca(2+) uptake and for interaction with MCUR1. It is not required for targeting to the mitochondria, oligomerization, interaction with MICU1 and MICU2, or assembly of the uniplex complex. Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH). The critical DXXE motif connecting the transmembrane regions forms a pentameric barrel that constitutes the mouth of the pore. Inside the barrel, two acidic residues are in position to form two carboxylate rings. In absence of SMDT1/EMRE regulator, the calcium ions cannot exit the channel, suggesting that SMDT1/EMRE-binding induces conformational rearrangements to allow calcium to exit. Phosphorylation by CaMK2 in heart leads to increased MCU current. The regulation of MCU by CaMK2 is however subject to discussion: another group was unable to reproduce these results. Phosphorylated on tyrosines by PTK2B/PYK2, promoting oligomerization. No visible phenotype (PubMed:24212091, PubMed:26057074). Although slightly smaller, mice are grossly normal. Only minor alterations in basal energetics are observed. Cells show a strong reduction, but not a complete absence, of mitochondrial matrix calcium. The skeletal muscles exhibit alterations in the phosphorylation and activity of pyruvate dehydrogenase and mice show defects in ability to perform strenuous work. Mitochondria lack evidence for calcium-induced permeability transition pore (PTP) opening (PubMed:24212091). Mitochondria from mutant mouse heart muscle have impaired Ca(2+) uptake and reduced Ca(2+) levels in the mitochondrial matrix; still, mutant mice have apparently normal heart function and display no cardiac defects (PubMed:26057074). Conditional mutant mice with cardiomyocyte-specific deletion of Mcu in adults display no overt baseline phenotype and are protected against mitochondrial calcium overload by preventing the activation of the mitochondrial permeability transition pore (PubMed:26119742, PubMed:26119731). Mice however lack contractile responsiveness to acute stress and 'fight-or-flight' response: they produce mitochondria refractory to acute calcium uptake, with impaired ATP production and inhibited mitochondrial permeability transition pore opening upon acute calcium challenge (PubMed:26119742, PubMed:26119731). Belongs to the MCU (TC 1.A.77) family. calcium channel activity protein binding mitochondrion mitochondrial inner membrane ion transport calcium ion transport mitochondrial calcium ion transport uniporter activity membrane integral component of membrane calcium-mediated signaling integral component of mitochondrial inner membrane positive regulation of insulin secretion calcium channel complex mitochondrial calcium uptake glucose homeostasis identical protein binding protein oligomerization mitochondrial calcium ion homeostasis positive regulation of mitochondrial calcium ion concentration calcium ion transmembrane transport uniplex complex uc007fdt.1 uc007fdt.2 uc007fdt.3 uc007fdt.4 
ENSMUST00000020315.13 Cand1 ENSMUST00000020315.13 cullin associated and neddylation disassociated 1 (from RefSeq NM_027994.1) CAND1_MOUSE D10Ertd516e ENSMUST00000020315.1 ENSMUST00000020315.10 ENSMUST00000020315.11 ENSMUST00000020315.12 ENSMUST00000020315.2 ENSMUST00000020315.3 ENSMUST00000020315.4 ENSMUST00000020315.5 ENSMUST00000020315.6 ENSMUST00000020315.7 ENSMUST00000020315.8 ENSMUST00000020315.9 Kiaa0829 NM_027994 Q6PFR0 Q6ZQ38 Q9CV45 uc007hec.1 uc007hec.2 uc007hec.3 uc007hec.4 Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (By similarity). Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1. Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with cullins. Interacts with ERCC6 (By similarity). Interacts with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5; these interactions are bridged by cullins and strongly inhibits the neddylation of cullins (By similarity). Cytoplasm Nucleus Note=Predominantly cytoplasmic. Belongs to the CAND family. Sequence=AAH57457.1; Type=Erroneous initiation; Evidence=; Sequence=BAB26438.1; Type=Erroneous initiation; Evidence=; Sequence=BAC98035.1; Type=Erroneous initiation; Evidence=; ubiquitin ligase complex protein binding nucleus nucleoplasm cytoplasm Golgi apparatus cytosol SCF complex assembly protein ubiquitination TBP-class protein binding cell differentiation cullin-RING ubiquitin ligase complex negative regulation of catalytic activity positive regulation of transcription, DNA-templated positive regulation of RNA polymerase II transcriptional preinitiation complex assembly uc007hec.1 uc007hec.2 uc007hec.3 uc007hec.4 
ENSMUST00000020316.4 Tbk1 ENSMUST00000020316.4 TANK-binding kinase 1 (from RefSeq NM_019786.4) ENSMUST00000020316.1 ENSMUST00000020316.2 ENSMUST00000020316.3 NM_019786 Q9CT90 Q9DC03 Q9WUN2 TBK1_MOUSE Tbk1 uc007hft.1 uc007hft.2 uc007hft.3 uc007hft.4 uc007hft.5 uc007hft.6 Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:15210742, PubMed:15661922). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (By similarity). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (By similarity). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (By similarity). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1- containing-complexes (By similarity). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (By similarity). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (By similarity). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (By similarity). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (By similarity). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (By similarity). Phosphorylates and activates AKT1 (By similarity). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity (PubMed:23396211). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Kinase activity is inhibited competitively by amlexanox. Homodimer (PubMed:23746807). Interacts with DDX3X, TIRAP and TRAF2 (By similarity). Part of a ternary complex consisting of TANK, TRAF2 and TBK1 (By similarity). Interacts with AZI2, TANK and TBKBP1; these interactions are mutually exclusive and mediate TBK1 activation (By similarity). Interacts with GSK3B; this interaction promotes TBK1 self-association and autophosphorylation (By similarity). Interacts with SIKE1; SIKE1 is associated with TBK1 under physiological condition and dissociated from TBK1 upon viral infection or TLR3 stimulation (By similarity). Interacts with IRF3, leading to IRF3 phosphorylation (By similarity). Interacts with RIGI (By similarity). Interacts with CYLD (By similarity). Interacts with OPTN and TRAF3 (By similarity). Interacts with SRC (By similarity). Interacts with the exocyst complex subunit SEC5/EXOC2; this interaction is sufficient to trigger TBK1 activity (By similarity). Interacts with STING1, leading to STING1 phosphorylation (By similarity). Interacts with IFIT3 (via N-terminus) (By similarity). Interacts with MAVS; interaction only takes place in the presence of IFIT3 and leads to MAVS phosphorylation (By similarity). Interacts (via protein kinase domain) with TTLL12 (via TTL domain); the interaction prevents MAVS binding to TBK1 (By similarity). Interacts with TICAM1; this interaction is enhanced in the presence of WDFY1 and leads to TICAM1 phosphorylation (By similarity). Interacts with TRIM26 (By similarity). Interacts with TRIM23 (By similarity). Interacts with TTC4 and IKBKE (By similarity). Interacts with HNRNPA2B1 (PubMed:31320558). Interacts with DDX3X (By similarity). Interacts with TRIM14 (By similarity). Interacts with CEP170; efficient complex formation may be dependent on the presence of CCDC61 (By similarity). Interacts with TRAF3IP3 (By similarity). Interacts with HSP90AA1; the interaction mediates TBK1 association with TOMM70 (By similarity). Interacts with TAX1BP1 (By similarity). Q9WUN2; Q3TBT3: Sting1; NbExp=3; IntAct=EBI-764193, EBI-3862093; Q9WUN2; P70347: Tank; NbExp=7; IntAct=EBI-764193, EBI-646116; Q9WUN2; Q9WUN2: Tbk1; NbExp=5; IntAct=EBI-764193, EBI-764193; Q9WUN2; A2A9T0: Tbkbp1; NbExp=2; IntAct=EBI-764193, EBI-7987134; Q9WUN2; Q80UF7: Ticam1; NbExp=2; IntAct=EBI-764193, EBI-3649271; Q9WUN2; O41932: GAMMAHV.ORF11; Xeno; NbExp=3; IntAct=EBI-764193, EBI-9544132; Cytoplasm Note=Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2. Comprises A N-terminal kinase domain, a ubiquitin-like domain and a C-terminal coiled-coil region mediating homodimerization. Autophosphorylation at Ser-172 activates the kinase, and is an essential step for virus-triggered signaling. Phosphorylated by IKBKB/IKKB at Ser-172. Phosphorylation requires homodimerization and ubiquitination at Lys-30 and Lys-401. Dephosphorylated at Ser-172 by PPM1B and this negatively regulates its role in mediating antiviral response. 'Lys-63'-linked polyubiquitination by MIB1 after RNA virus infection, or by NRDP1 after LPS stimulation at Lys-30 and Lys-401, participates in kinase activation. 'Lys-48'-linked polyubiquitination at Lys-670 by DTX4 leads to proteasomal degradation. 'Lys-48'-linked polyubiquitination by TRAIP also leads to proteasomal degradation. 'Lys-48'-linked polyubiquitination by TRAF7; leading to proteasomal degradation. 'Lys-63'-linked polyubiquitination by RNF128 at Lys-30 and Lys-401 leads to the activation of antiviral responses. 'Lys-48'-linked polyubiquitination after 'lys-33'-linked deubiquitination by USP38 promotes TBK1 degradation. Mice display embryonic lethality at 14.5 dpc due to massive liver degeneration and apoptosis. Embryonic fibroblasts from mice lacking Tbk1 exhibit dramatically reduced transcription of NF- kappa-B, as well as marked defects in interferon alpha and beta, and RANTES gene expression after infection with Sendai or Newcastle disease virus. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. nucleotide binding activation of innate immune response immune system process nucleic acid binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleoplasm cytoplasm cytosol protein phosphorylation regulation of gene expression negative regulation of gene expression aggresome positive regulation of macroautophagy kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation protein phosphatase binding regulation of cellular metabolic process regulation of type I interferon production positive regulation of interferon-alpha production positive regulation of interferon-beta production identical protein binding positive regulation of I-kappaB kinase/NF-kappaB signaling dendritic cell proliferation innate immune response positive regulation of interferon-beta biosynthetic process positive regulation of transcription from RNA polymerase II promoter defense response to Gram-positive bacterium phosphoprotein binding defense response to virus positive regulation of type I interferon-mediated signaling pathway positive regulation of xenophagy uc007hft.1 uc007hft.2 uc007hft.3 uc007hft.4 uc007hft.5 uc007hft.6 
ENSMUST00000020317.8 Pno1 ENSMUST00000020317.8 partner of NOB1 homolog (from RefSeq NM_025443.2) ENSMUST00000020317.1 ENSMUST00000020317.2 ENSMUST00000020317.3 ENSMUST00000020317.4 ENSMUST00000020317.5 ENSMUST00000020317.6 ENSMUST00000020317.7 NM_025443 PNO1_MOUSE Q9CPS7 uc007icc.1 uc007icc.2 uc007icc.3 uc007icc.4 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'- end of 18S rRNA. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus Belongs to the PNO1 family. nucleic acid binding RNA binding nucleus nucleolus biological_process uc007icc.1 uc007icc.2 uc007icc.3 uc007icc.4 
ENSMUST00000020322.12 Srgap1 ENSMUST00000020322.12 SLIT-ROBO Rho GTPase activating protein 1, transcript variant 2 (from RefSeq NM_001242411.1) Arhgap13 ENSMUST00000020322.1 ENSMUST00000020322.10 ENSMUST00000020322.11 ENSMUST00000020322.2 ENSMUST00000020322.3 ENSMUST00000020322.4 ENSMUST00000020322.5 ENSMUST00000020322.6 ENSMUST00000020322.7 ENSMUST00000020322.8 ENSMUST00000020322.9 NM_001242411 Q08E84 Q91Z69 SRGP1_MOUSE uc007hgc.1 uc007hgc.2 uc007hgc.3 uc007hgc.4 GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42 (By similarity). Homodimer (Probable). Forms a heterooligomer with SRGAP2 and SRGAP3 through its F-BAR domain. Interacts with CDC42 and RHOA. Interacts with FASLG (By similarity). Interacts (via SH3 domain) with ROBO1. The F-BAR domain mediates oligomerization, binds membranes, and constrains plasma membrane protrusions. Sequence=AAL27030.1; Type=Erroneous initiation; Evidence=; GTPase activator activity protein binding cytoplasm signal transduction Rho protein signal transduction cell migration Rho GTPase binding negative regulation of cell migration positive regulation of GTPase activity Rac GTPase binding uc007hgc.1 uc007hgc.2 uc007hgc.3 uc007hgc.4 
ENSMUST00000020323.7 Avpr1a ENSMUST00000020323.7 arginine vasopressin receptor 1A (from RefSeq NM_016847.2) ENSMUST00000020323.1 ENSMUST00000020323.2 ENSMUST00000020323.3 ENSMUST00000020323.4 ENSMUST00000020323.5 ENSMUST00000020323.6 NM_016847 Q62463 Q62464 Q9QYH2 V1AR_MOUSE uc007hge.1 uc007hge.2 uc007hge.3 This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D49730.1, BC024149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Involved in social memory formation. Cell membrane; Multi-pass membrane protein. Knockout mice display deficits in individual discrimination. Male mice lacking functional AVPR1A (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and non-social olfactory learning and memory tasks. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. regulation of systemic arterial blood pressure by vasopressin maternal aggressive behavior positive regulation of systemic arterial blood pressure G-protein coupled receptor activity vasopressin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration negative regulation of female receptivity grooming behavior positive regulation of cell proliferation response to organic substance response to inorganic substance positive regulation of heart rate positive regulation of glutamate secretion myotube differentiation membrane integral component of membrane peptide hormone binding calcium-mediated signaling telencephalon development positive regulation of cell growth positive regulation of prostaglandin biosynthetic process cytoplasmic vesicle V1A vasopressin receptor binding positive regulation of cellular pH reduction cellular response to hormone stimulus social behavior positive regulation of renal sodium excretion cellular response to water deprivation maternal behavior sperm ejaculation penile erection positive regulation of blood pressure positive regulation of vasoconstriction response to corticosterone negative regulation of transmission of nerve impulse uc007hge.1 uc007hge.2 uc007hge.3 
ENSMUST00000020329.13 Egfr ENSMUST00000020329.13 epidermal growth factor receptor, transcript variant 1 (from RefSeq NM_207655.2) EGFR_MOUSE ENSMUST00000020329.1 ENSMUST00000020329.10 ENSMUST00000020329.11 ENSMUST00000020329.12 ENSMUST00000020329.2 ENSMUST00000020329.3 ENSMUST00000020329.4 ENSMUST00000020329.5 ENSMUST00000020329.6 ENSMUST00000020329.7 ENSMUST00000020329.8 ENSMUST00000020329.9 Egfr NM_207655 Q01279 uc007ibo.1 uc007ibo.2 uc007ibo.3 Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:8404850). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (By similarity). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (By similarity). Plays a role in enhancing learning and memory performance (PubMed:20639532). Plays a role in mammalian pain signaling (long- lasting hypersensitivity) (PubMed:35131940). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Endocytosis and inhibition of the activated EGFR by phosphatases like PTPRJ and PTPRK constitute immediate regulatory mechanisms. Upon EGF-binding phosphorylates EPS15 that regulates EGFR endocytosis and activity. Moreover, inducible feedback inhibitors including LRIG1, SOCS4, SOCS5 and ERRFI1 constitute alternative regulatory mechanisms for the EGFR signaling. Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its autophosphorylation. Heterodimer with ERBB2. Forms a complex with CCDC88A/GIV (via SH2-like region) and GNAI3 which leads to enhanced EGFR signaling and triggering of cell migration; binding of CCDC88A requires autophosphorylation of the EGFR C-terminal region, and ligand stimulation is required for recruitment of GNAI3 to the complex (By similarity). Interacts with ERRFI1; inhibits dimerization of the kinase domain and autophosphorylation. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. Interacts with GRB2; an adapter protein coupling the receptor to downstream signaling pathways. Interacts with GAB2; involved in signaling downstream of EGFR. Interacts with STAT3; mediates EGFR downstream signaling in cell proliferation. Interacts with RIPK1; involved in NF- kappa-B activation. Interacts (autophosphorylated) with CBL, CBLB and CBLC; involved in EGFR ubiquitination and regulation; interaction with CBL is reduced in the presence of tensin TNS4. Interacts with SOCS5; regulates EGFR degradation through ELOC- and ELOB-mediated ubiquitination and proteasomal degradation. Interacts with PRMT5; methylates EGFR and enhances interaction with PTPN6. Interacts (phosphorylated) with PTPN6; inhibits EGFR-dependent activation of MAPK/ERK. Interacts with COPG1; essential for regulation of EGF- dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with TNK2; this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts with PCNA; positively regulates PCNA. Interacts with PELP1. Interacts with MUC1. Interacts with AP2M1. Interacts with FER. Interacts (via SH2 domains) with GRB2, NCK1 and NCK2. Interacts with EPS8; mediates EPS8 phosphorylation. Interacts with ATXN2. Interacts with GAREM1. Interacts (ubiquitinated) with ANKRD13A/B/D; the interaction is direct and may regulate EGFR internalization after EGF stimulation. Interacts with GPER1; the interaction occurs in an estrogen-dependent manner. Interacts (via C-terminal cytoplasmic kinase domain) with ZPR1 (via zinc fingers). Interacts with RNF115 and RNF126. Interacts with GPRC5A (via its transmembrane domain) (PubMed:25744720). Interacts with FAM83B; positively regulates EGFR inducing its autophosphorylation in absence of stimulation by EGF (By similarity). Interacts with LAPTM4B; positively correlates with EGFR activation (By similarity). Interacts with STX19 (PubMed:16420529). Interacts with CD44 (By similarity). Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization (By similarity). Interacts with PIKFYVE (PubMed:17909029). Interacts with NEU3. Interacts with TRAF4. Interacts with the ant venom OMEGA- myrmeciitoxin(02)-Mg1a (PubMed:35131940). Q01279; P22682: Cbl; NbExp=2; IntAct=EBI-6296235, EBI-640919; Q01279; P32883: Kras; NbExp=3; IntAct=EBI-6296235, EBI-644267; Q01279; Q15109: AGER; Xeno; NbExp=2; IntAct=EBI-6296235, EBI-1646426; Q01279; P01133: EGF; Xeno; NbExp=3; IntAct=EBI-6296235, EBI-640857; Cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single- pass type I membrane protein Golgi apparatus membrane ; Single-pass type I membrane protein Nucleus membrane ; Single-pass type I membrane protein Endosome Endosome membrane Nucleus Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF). Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occurs. Deubiquitinated by OTUD7B, preventing degradation (By similarity). Ubiquitinated by RNF115 and RNF126. Ubiquitinated by ZNRF1 or CBL at different lysines in response to EGF stimulation; leading to recruitment of the ESCRT machinery and subsequent degradation in the lysosomes (By similarity). Deubiquitinated by UCHL1 leading to the inhibition of its degradation (PubMed:32494592). Phosphorylated on Tyr residues in response to EGF. Phosphorylation at Ser-697 is partial and occurs only if Thr-695 is phosphorylated. Phosphorylation at Thr-680 and Thr-695 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Dephosphorylation by PTPRJ prevents endocytosis and stabilizes the receptor at the plasma membrane. Autophosphorylation at Tyr-1199 is stimulated by methylation at Arg-1199 and enhances interaction with PTPN6. Autophosphorylation at Tyr-1092 and/or Tyr-1110 recruits STAT3. Dephosphorylated by PTPN1 and PTPN2. Palmitoylated on Cys residues by ZDHHC20. Palmitoylation inhibits internalization after ligand binding, and increases the persistence of tyrosine-phosphorylated EGFR at the cell membrane. Palmitoylation increases the amplitude and duration of EGFR signaling. Methylated. Methylation at Arg-1199 by PRMT5 stimulates phosphorylation at Tyr-1197. Mice are growth retarded and die at different stages of development depending on their genetic background. Embryonic death is due to placental defects. Mice surviving until birth or later display brain, bone, heart and various epithelial development defects in several organs, including skin, lung and gastrointestinal tract. Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Golgi membrane nucleotide binding activation of MAPKK activity cell morphogenesis liver development embryonic placenta development positive regulation of protein phosphorylation hair follicle development chromatin binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity epidermal growth factor-activated receptor activity receptor binding integrin binding protein binding calmodulin binding ATP binding nucleus cytoplasm endosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane integral component of plasma membrane translation protein phosphorylation response to osmotic stress response to oxidative stress signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway multicellular organism development salivary gland morphogenesis midgut development learning or memory circadian rhythm cell proliferation positive regulation of cell proliferation epidermis development basal plasma membrane cell surface endosome membrane positive regulation of nitric oxide mediated signal transduction magnesium ion homeostasis regulation of phosphatidylinositol 3-kinase signaling response to organic cyclic compound membrane integral component of membrane diterpenoid metabolic process kinase activity phosphorylation basolateral plasma membrane apical plasma membrane transferase activity peptidyl-tyrosine phosphorylation enzyme binding protein kinase binding protein phosphatase binding cerebral cortex cell migration endocytic vesicle cell differentiation nitric-oxide synthase regulator activity positive regulation of cell growth lung development positive regulation of cell migration ubiquitin protein ligase binding early endosome membrane nuclear membrane response to estradiol positive regulation of superoxide anion generation macromolecular complex positive regulation of peptidyl-serine phosphorylation response to cobalamin response to hydroxyisoflavone response to lipid cellular response to reactive oxygen species intracellular signal transduction cellular response to drug peptidyl-tyrosine autophosphorylation wound healing regulation of cell proliferation negative regulation of protein catabolic process positive regulation of phosphorylation ovulation cycle hydrogen peroxide metabolic process identical protein binding negative regulation of apoptotic process receptor complex positive regulation of MAP kinase activity tongue development membrane raft synapse positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of DNA repair positive regulation of DNA replication positive regulation of bone resorption positive regulation of transcription, DNA-templated positive regulation of vasoconstriction negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter regulation of JNK cascade protein autophosphorylation protein heterodimerization activity astrocyte activation positive regulation of fibroblast proliferation epidermal growth factor binding perinuclear region of cytoplasm digestive tract morphogenesis positive regulation of smooth muscle cell proliferation neuron projection morphogenesis positive regulation of epithelial cell proliferation positive regulation of inflammatory response regulation of peptidyl-tyrosine phosphorylation regulation of nitric-oxide synthase activity actin filament binding response to calcium ion positive regulation of protein kinase B signaling positive regulation of synaptic transmission, glutamatergic morphogenesis of an epithelial fold eyelid development in camera-type eye response to UV-A regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to amino acid stimulus cellular response to mechanical stimulus cellular response to cadmium ion cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus cellular response to estradiol stimulus cellular response to dexamethasone stimulus positive regulation of canonical Wnt signaling pathway liver regeneration multivesicular body, internal vesicle lumen cell-cell adhesion positive regulation of protein kinase C activity positive regulation of G1/S transition of mitotic cell cycle positive regulation of NIK/NF-kappaB signaling positive regulation of prolactin secretion positive regulation of protein localization to early endosome positive regulation of protein localization to plasma membrane positive regulation of production of miRNAs involved in gene silencing by miRNA negative regulation of cardiocyte differentiation uc007ibo.1 uc007ibo.2 uc007ibo.3 
ENSMUST00000020339.10 Tbc1d15 ENSMUST00000020339.10 TBC1 domain family, member 15, transcript variant 2 (from RefSeq NM_025706.4) ENSMUST00000020339.1 ENSMUST00000020339.2 ENSMUST00000020339.3 ENSMUST00000020339.4 ENSMUST00000020339.5 ENSMUST00000020339.6 ENSMUST00000020339.7 ENSMUST00000020339.8 ENSMUST00000020339.9 NM_025706 Q3UI41 Q9CXF4 TBC15_MOUSE uc007hax.1 uc007hax.2 uc007hax.3 uc007hax.4 Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6. Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction (By similarity). Interacts with ARMC12 (By similarity). Cytoplasm Ubiquitous, with highest expression in heart, liver and testis and lower expression in brain, spleen, lung, kidney and skeletal muscle. PubMed:16055087 showns that TBC1D15 can also functions as GTPase activating for RAB11 at a lower extent than for RAB7A, however this function is not confirmed by PubMed:20363736. GTPase activator activity extracellular region cytoplasm mitochondrion intracellular protein transport Rab GTPase binding regulation of GTPase activity activation of GTPase activity uc007hax.1 uc007hax.2 uc007hax.3 uc007hax.4 
ENSMUST00000020340.15 Pcsk4 ENSMUST00000020340.15 proprotein convertase subtilisin/kexin type 4 (from RefSeq NM_008793.2) ENSMUST00000020340.1 ENSMUST00000020340.10 ENSMUST00000020340.11 ENSMUST00000020340.12 ENSMUST00000020340.13 ENSMUST00000020340.14 ENSMUST00000020340.2 ENSMUST00000020340.3 ENSMUST00000020340.4 ENSMUST00000020340.5 ENSMUST00000020340.6 ENSMUST00000020340.7 ENSMUST00000020340.8 ENSMUST00000020340.9 NM_008793 Nec-3 Nec3 P29121 PCSK4_MOUSE Q62094 uc007gcs.1 uc007gcs.2 uc007gcs.3 uc007gcs.4 Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (PubMed:9192653, PubMed:16371590, PubMed:19342015, PubMed:21302280). Also plays a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (By similarity). May also participate in folliculogenesis in the ovaries (PubMed:11164898). The proPCSK4 form interacts with HSPA5; the interaction takes place at the endoplasmic reticulum. Cytoplasmic vesicle, secretory vesicle, acrosome membrane Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=mPC4-A; IsoId=P29121-1; Sequence=Displayed; Name=2; IsoId=P29121-2; Sequence=VSP_011268; Name=3; Synonyms=mPC4-B; IsoId=P29121-3; Sequence=VSP_011271; Name=4; Synonyms=mPC4-C; IsoId=P29121-4; Sequence=VSP_011272; Name=5; Synonyms=E; IsoId=P29121-5; Sequence=VSP_011266; Name=6; Synonyms=D; IsoId=P29121-6; Sequence=VSP_011267; Name=7; Synonyms=B; IsoId=P29121-7; Sequence=VSP_011269; Name=8; Synonyms=C; IsoId=P29121-8; Sequence=VSP_011270; Expressed abundantly in the testis since postnatal Day 16 (PubMed:1372895, PubMed:16371590, PubMed:21302280). In testis, strongly detected in round and elongated spermatids as well as spermatocytes. Also observed in residual bodies engulfed by Sertoli cells at spermatogenic stages VIII and IX (PubMed:16371590). In ovaries, expressed in macrophage-like cells of the ovarian theca, interstitium and corpora lutea (PubMed:11164898). Detected only after the 20th day of postnatal development. Mainly expressed in the round spermatids. Expressed mainly in the early stages of spermiogenesis. N-glycosylated. Synthesized in the endoplasmic reticulum as a zymogen, is matured by autocatalytic cleavage between the prodomain and the catalytic domain. Knockout males show impaired fertility (PubMed:9192653). Sperm from mutants exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability (PubMed:16371590). They have abnormal acrosome formation during spermatogenesis (PubMed:22357636). Sperm proteins are hyper-tyrosine phosphorylated during capacitation (PubMed:19342015). In females, the percent of successful mating is comparable to that of their PCSK4 +/- female littermates, however the average litter size of the former is half that of the latter. Knockout ovaries treated with gonatropin are generally smaller, less hyperemic and with fewer corpora lutea than wild type. This difference is associated with a 20-fold lower level of circulating progesterone (PubMed:9192653). Belongs to the peptidase S8 family. Furin subfamily. acrosomal vesicle acrosomal membrane serine-type endopeptidase activity endoplasmic reticulum lumen trans-Golgi network proteolysis binding of sperm to zona pellucida acrosome reaction peptidase activity serine-type peptidase activity fertilization membrane protein processing peptide hormone processing hydrolase activity reproductive process integral component of Golgi membrane cytoplasmic vesicle sperm capacitation uc007gcs.1 uc007gcs.2 uc007gcs.3 uc007gcs.4 
ENSMUST00000020341.9 2310011J03Rik ENSMUST00000020341.9 RIKEN cDNA 2310011J03 gene (from RefSeq NM_025521.3) CS025_MOUSE ENSMUST00000020341.1 ENSMUST00000020341.2 ENSMUST00000020341.3 ENSMUST00000020341.4 ENSMUST00000020341.5 ENSMUST00000020341.6 ENSMUST00000020341.7 ENSMUST00000020341.8 NM_025521 Q9D7E4 uc007gcq.1 uc007gcq.2 uc007gcq.3 Belongs to the UPF0449 family. molecular_function cellular_component biological_process uc007gcq.1 uc007gcq.2 uc007gcq.3 
ENSMUST00000020343.9 Rab21 ENSMUST00000020343.9 RAB21, member RAS oncogene family (from RefSeq NM_024454.1) ENSMUST00000020343.1 ENSMUST00000020343.2 ENSMUST00000020343.3 ENSMUST00000020343.4 ENSMUST00000020343.5 ENSMUST00000020343.6 ENSMUST00000020343.7 ENSMUST00000020343.8 NM_024454 Q0PD35 Q0PD35_MOUSE Rab21 uc007haz.1 uc007haz.2 uc007haz.3 Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity GTP binding endosome trans-Golgi network signal transduction anterograde axonal transport cytoplasmic side of plasma membrane vesicle membrane membrane regulation of exocytosis GDP binding regulation of axon extension Rab protein signal transduction Golgi cisterna membrane neuron projection synapse positive regulation of receptor-mediated endocytosis cytoplasmic side of early endosome membrane axon cytoplasm positive regulation of early endosome to late endosome transport uc007haz.1 uc007haz.2 uc007haz.3 
ENSMUST00000020350.15 Lgr5 ENSMUST00000020350.15 leucine rich repeat containing G protein coupled receptor 5 (from RefSeq NM_010195.2) ENSMUST00000020350.1 ENSMUST00000020350.10 ENSMUST00000020350.11 ENSMUST00000020350.12 ENSMUST00000020350.13 ENSMUST00000020350.14 ENSMUST00000020350.2 ENSMUST00000020350.3 ENSMUST00000020350.4 ENSMUST00000020350.5 ENSMUST00000020350.6 ENSMUST00000020350.7 ENSMUST00000020350.8 ENSMUST00000020350.9 Fex Gpr49 LGR5_MOUSE NM_010195 Q3V1L2 Q9Z1P4 uc007hbi.1 uc007hbi.2 uc007hbi.3 The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK132387.1, AF110818.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. Identified in a complex composed of RNF43, LGR5 and RSPO1 (By similarity). Also interacts with other R-spondin ligands, including RSPO2, RSPO3 and RSPO4 (By similarity). Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Expressed in the intestinal epithelium (at protein level) (PubMed:22510880). Expressed in the gonads, the adrenal gland, and in the brain. In the central nervous system expression is restricted to the olfactory bulb. In the adrenal gland detected only in the neural-crest derived chromaffin cells of the medulla, but not in the cells of the adrenal cortex. In the gonads, the expression is high in Graafian follicle, but absent from primary and secondary follicles. In the intestine, exclusively expressed in cycling crypt base columnar cells. Expressed in the lower bulge and secondary germ area of telogen hair follicles and in the lower outer root sheath of anagen hair follicle. First expressed at 8.5 dpc in a few cells of the ectoplacental cone and, at 9.5 dpc, in a greater number of cells in the labyrinthine region of the forming placenta. In the embryo per se, expression starts at 9.5 dpc. At 10.5 dpc, detected in the facial area in the tissue overlaying the mandibular cleft and in the optic cup. In the central nervous system, expressed in the neuroepithelium at the roof of the mesencephalon and in the spinal cord. At 11.5 dpc, in the central nervous system, expressed in the neuroepithelium at the border between mes- and metencephalon and that lining the fourth ventricle and the retina, as well as in the spinal cord. Outside the nervous system, at 11.5 dpc, expressed in the mesenchyme over-laying the mandibular cleft, in the distal limb buds, especially the hind limb buds, as well as in the perichordal mesenchyme in the rostral region of the embryo. At 12.5 dpc, in the central nervous system, highly expressed in the rhombencephalic isthmus. In the facial area, expressed in the mesenchyme surrounding the olfactory epithelium and the forming vibrissae. Expression in the hind and front limb buds increases and spreads to more proximal directions, but is restricted to the area were the digits develop. At 13.5 dpc, the expression in the brain becomes restricted to the border between mes- and diencephalon. Also detected in the pituitary. Strongly expressed in the mesenchyme adjacent to the mandibular cleft, as well as in the most lateral aspects of the tongue and the teeth anlagen. Weak expression in the body wall and mesenchyme surrounding internal organs. At 14.5 dpc, becomes hardly detectable in the nervous system. In the body, expressed in the perichondrium, but levels decrease with ongoing age (PubMed:9920770). In the limbs, at 14.5 dpc, expressed in the mesenchyme, but not in the overlying ectoderm of the limb bud. In developing lungs, at 14.5 dpc, expressed at low levels in both the epithelium and mesenchyme lineages (PubMed:29769720). Mice exhibit malformation of the tongue and of lower jam causing newborns to swallow air leading to 100% neonatal lethality. Conditional knockout of both Lgr4 and Lgr5 in the gut results in Wnt signaling inhibition and results in the rapid demise of intestinal crypts (PubMed:21727895). Simultaneous knockdown of LGR4, LGR5 and LGR6 results in developmental phenotypes, such as cleft palate and ankyloglossia, but not in tetra-amelia with lung agenesis (PubMed:29769720). LGR5 is used as a marker of adult tissue stem cells in the intestine, stomach, hair follicle, and mammary epithelium. Belongs to the G-protein coupled receptor 1 family. hair follicle development transmembrane signaling receptor activity Golgi apparatus plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity G-protein coupled peptide receptor activity hormone-mediated signaling pathway oocyte differentiation membrane integral component of membrane protein-hormone receptor activity trans-Golgi network membrane regulation of cell proliferation inner ear development positive regulation of canonical Wnt signaling pathway epithelial cell proliferation involved in renal tubule morphogenesis G-protein coupled receptor activity uc007hbi.1 uc007hbi.2 uc007hbi.3 
ENSMUST00000020362.3 Kcnmb1 ENSMUST00000020362.3 potassium large conductance calcium-activated channel, subfamily M, beta member 1 (from RefSeq NM_031169.4) ENSMUST00000020362.1 ENSMUST00000020362.2 Kcnmb1 NM_031169 Q5SQK1 Q5SQK1_MOUSE uc007iks.1 uc007iks.2 uc007iks.3 uc007iks.4 Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer. Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer. Membrane ulti-pass membrane protein N-glycosylated. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily. potassium ion transport aging calcium-activated potassium channel activity potassium channel regulator activity membrane integral component of membrane response to calcium ion cellular response to ethanol cellular response to hypoxia potassium ion transmembrane transport positive regulation of potassium ion transmembrane transport cellular response to bile acid uc007iks.1 uc007iks.2 uc007iks.3 uc007iks.4 
ENSMUST00000020365.15 Pwwp3a ENSMUST00000020365.15 PWWP domain containing 3A, DNA repair factor (from RefSeq NM_023431.6) ENSMUST00000020365.1 ENSMUST00000020365.10 ENSMUST00000020365.11 ENSMUST00000020365.12 ENSMUST00000020365.13 ENSMUST00000020365.14 ENSMUST00000020365.2 ENSMUST00000020365.3 ENSMUST00000020365.4 ENSMUST00000020365.5 ENSMUST00000020365.6 ENSMUST00000020365.7 ENSMUST00000020365.8 ENSMUST00000020365.9 Mum1 NM_023431 PWP3A_MOUSE Q3TCZ4 Q6DID5 Q6NST9 Q8C5E3 Q8R1V6 Q9R1R7 uc007gch.1 uc007gch.2 uc007gch.3 Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity). Interacts with TP53BP1 (via BRCT domain); the interaction is not dependent on its phosphorylation status. Binds nucleosomes. Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3) (in vitro) (By similarity). Nucleus Note=Recruited to DNA damage sites via its interaction with the BRCT domain of TP53BP1. The PWWP domain mediates the interaction with nucleosomes. Belongs to the PWWP3A family. Sequence=AAH23031.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAA82658.1; Type=Frameshift; Evidence=; Sequence=BAC37397.1; Type=Miscellaneous discrepancy; Note=Intron retention. This sequence is incomplete at the 5'-end.; Evidence=; nucleus cytosol DNA repair chromatin organization cellular response to DNA damage stimulus nucleosome binding uc007gch.1 uc007gch.2 uc007gch.3 
ENSMUST00000020366.8 Gabrp ENSMUST00000020366.8 gamma-aminobutyric acid type A receptor subunit pi (from RefSeq NM_146017.3) ENSMUST00000020366.1 ENSMUST00000020366.2 ENSMUST00000020366.3 ENSMUST00000020366.4 ENSMUST00000020366.5 ENSMUST00000020366.6 ENSMUST00000020366.7 GBRP_MOUSE NM_146017 Q3TUT6 Q8QZW7 uc007ikm.1 uc007ikm.2 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and epsilon. A sixth class of subunit: Rho form homomeric GABA receptors that do not appear to coexist with GABA(A) receptor subunits but with GABA(C) receptor subunits. Subunit Pi can also bind this complex (By similarity). Postsynaptic cell membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRP sub- subfamily. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction chemical synaptic transmission membrane integral component of membrane cell junction ion transmembrane transport chloride channel complex regulation of membrane potential neuron projection synapse postsynaptic membrane neurological system process chloride transmembrane transport uc007ikm.1 uc007ikm.2 
ENSMUST00000020372.6 Uqcr11 ENSMUST00000020372.6 ubiquinol-cytochrome c reductase, complex III subunit XI (from RefSeq NM_025650.2) ENSMUST00000020372.1 ENSMUST00000020372.2 ENSMUST00000020372.3 ENSMUST00000020372.4 ENSMUST00000020372.5 NM_025650 Q3TFX1 Q9CPX8 QCR10_MOUSE Uqcr uc007gde.1 uc007gde.2 uc007gde.3 Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1 stability. Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:19026783). Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the UQCR11/QCR10 family. mitochondrion mitochondrial inner membrane ubiquinol-cytochrome-c reductase activity electron carrier activity membrane integral component of membrane electron transport chain oxidation-reduction process respiratory chain uc007gde.1 uc007gde.2 uc007gde.3 
ENSMUST00000020378.5 Best3 ENSMUST00000020378.5 bestrophin 3 (from RefSeq NM_001007583.1) BEST3_MOUSE ENSMUST00000020378.1 ENSMUST00000020378.2 ENSMUST00000020378.3 ENSMUST00000020378.4 NM_001007583 Q6H1V1 Vmd2l3 uc007hcp.1 uc007hcp.2 Forms calcium-sensitive chloride channels. Permeable to bicarbonate (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily. chloride channel activity plasma membrane ion transport chloride transport inorganic anion transport membrane integral component of membrane chloride channel complex negative regulation of ion transport chloride transmembrane transport uc007hcp.1 uc007hcp.2 
ENSMUST00000020381.5 Frs2 ENSMUST00000020381.5 fibroblast growth factor receptor substrate 2, transcript variant 1 (from RefSeq NM_177798.4) ENSMUST00000020381.1 ENSMUST00000020381.2 ENSMUST00000020381.3 ENSMUST00000020381.4 FRS2_MOUSE Frs2a NM_177798 Q8C180 uc007hct.1 uc007hct.2 uc007hct.3 Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. Part of a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Part of a complex containing GRB2 and CBL. Binds ALK, CKS2, FGFR1, RET, MAPK1/ERK2, MAPK3/ERK1 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. Interacts with NTRK1, NTRK2 and NTRK3 (phosphorylated upon ligand-binding) (By similarity). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Q8C180; Q60631: Grb2; NbExp=5; IntAct=EBI-6880000, EBI-1688; Membrane ; Lipid- anchor Ubiquitous. Expression is highest in brain, kidney, lung and testis. Phosphorylated on tyrosine residues upon stimulation by FGF2 or NGFB. Phosphorylated by ULK2 (in vitro). Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. activation of MAPK activity gastrulation with mouth forming second organ induction lens development in camera-type eye ventricular septum development transmembrane receptor protein tyrosine kinase adaptor activity fibroblast growth factor receptor binding neurotrophin TRKA receptor binding protein binding cytoplasm cytosol plasma membrane cell-cell junction cell-cell adherens junction transmembrane receptor protein tyrosine kinase signaling pathway neuroblast proliferation fibroblast growth factor receptor signaling pathway anterior/posterior axis specification, embryo membrane forebrain development regulation of apoptotic process cellular response to fibroblast growth factor stimulus optic placode formation involved in camera-type eye formation regulation of epithelial cell proliferation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis lens fiber cell development regulation of ERK1 and ERK2 cascade positive regulation of vascular smooth muscle cell proliferation negative regulation of cardiac muscle cell differentiation uc007hct.1 uc007hct.2 uc007hct.3 
ENSMUST00000020382.8 Yeats4 ENSMUST00000020382.8 YEATS domain containing 4 (from RefSeq NM_026570.4) ENSMUST00000020382.1 ENSMUST00000020382.2 ENSMUST00000020382.3 ENSMUST00000020382.4 ENSMUST00000020382.5 ENSMUST00000020382.6 ENSMUST00000020382.7 Gas41 NM_026570 Q9CR11 Q9CW86 YETS4_MOUSE Yeats4 uc007hcx.1 uc007hcx.2 uc007hcx.3 uc007hcx.4 Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (By similarity). Also able to recognize and bind crotonylated histone H3 (By similarity). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (By similarity). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (By similarity). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (PubMed:29900004). Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Interacts with MLLT10/AF10. Also interacts with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1. Nucleus The YEATS domain specifically recognizes and binds acylated histones, with a preference for histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). protein binding nucleus nucleoplasm chromatin organization regulation of transcription, DNA-templated protein C-terminus binding nuclear membrane NuA4 histone acetyltransferase complex regulation of growth histone H4 acetylation histone H2A acetylation uc007hcx.1 uc007hcx.2 uc007hcx.3 uc007hcx.4 
ENSMUST00000020383.6 Atp8b3 ENSMUST00000020383.6 ATPase, class I, type 8B, member 3 (from RefSeq NM_026094.3) AT8B3_MOUSE Atp8b3 ENSMUST00000020383.1 ENSMUST00000020383.2 ENSMUST00000020383.3 ENSMUST00000020383.4 ENSMUST00000020383.5 NM_026094 Q6UQ17 uc007gdo.1 uc007gdo.2 uc007gdo.3 P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:14975727, PubMed:19017724). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (PubMed:14975727). May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes (PubMed:14975727). Involved in acrosome reactions and binding of spermatozoa to zona pellucida (PubMed:19017724). Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38567, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57262, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38568; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Expressed in testis, specifically in spermatids within seminiferous tubules (at protein level). Developmentally regulated in testis. Expression is first detected at 17 days after birth and is later up-regulated up to adulthood amd maintained thereafter. Disrupted normal fertilization by sperm; sensitivity to sperm concentration and the time required to fertilize an egg is increased; the number of spermatozoa bound to zona pellucida is decreased. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. nucleotide binding magnesium ion binding acrosomal vesicle acrosomal membrane ATP binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane lipid transport Golgi organization binding of sperm to zona pellucida phospholipid transport membrane integral component of membrane cytoplasmic vesicle phospholipid translocation metal ion binding uc007gdo.1 uc007gdo.2 uc007gdo.3 
ENSMUST00000020397.11 Snrpd3 ENSMUST00000020397.11 small nuclear ribonucleoprotein D3 (from RefSeq NM_026095.5) ENSMUST00000020397.1 ENSMUST00000020397.10 ENSMUST00000020397.2 ENSMUST00000020397.3 ENSMUST00000020397.4 ENSMUST00000020397.5 ENSMUST00000020397.6 ENSMUST00000020397.7 ENSMUST00000020397.8 ENSMUST00000020397.9 NM_026095 P43331 P62320 Q3TV81 SMD3_MOUSE uc007fqm.1 uc007fqm.2 uc007fqm.3 Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (PubMed:19470752). Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity). Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (PubMed:19470752). Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct (By similarity). Cytoplasm, cytosol Nucleus Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs. Belongs to the snRNP core protein family. commitment complex spliceosomal snRNP assembly mRNA splicing, via spliceosome RNA binding nucleus nucleoplasm spliceosomal complex U5 snRNP U7 snRNP U1 snRNP U2 snRNP U4 snRNP U12-type spliceosomal complex telomerase holoenzyme complex cytoplasm cytosol RNA processing mRNA processing protein methylation RNA splicing nuclear body enzyme binding methylosome pICln-Sm protein complex SMN-Sm protein complex U4/U6 x U5 tri-snRNP complex telomerase RNA binding U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome histone pre-mRNA DCP binding U7 snRNA binding U1 snRNP binding uc007fqm.1 uc007fqm.2 uc007fqm.3 
ENSMUST00000020399.6 Cpm ENSMUST00000020399.6 carboxypeptidase M (from RefSeq NM_027468.1) CBPM_MOUSE ENSMUST00000020399.1 ENSMUST00000020399.2 ENSMUST00000020399.3 ENSMUST00000020399.4 ENSMUST00000020399.5 NM_027468 Q497S5 Q80V42 Q9CYH8 uc007hdi.1 uc007hdi.2 uc007hdi.3 Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins (By similarity). Reaction=Cleavage of C-terminal arginine or lysine residues from polypeptides.; EC=3.4.17.12; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Cell membrane ; Lipid-anchor, GPI- anchor Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80V42-1; Sequence=Displayed; Name=2; IsoId=Q80V42-2; Sequence=VSP_014606, VSP_014607; Belongs to the peptidase M14 family. Sequence=AAH47389.1; Type=Erroneous initiation; Evidence=; carboxypeptidase activity metallocarboxypeptidase activity extracellular space plasma membrane proteolysis peptide metabolic process peptidase activity metallopeptidase activity zinc ion binding membrane protein processing hydrolase activity anchored component of membrane metal ion binding uc007hdi.1 uc007hdi.2 uc007hdi.3 
ENSMUST00000020403.7 Csrp2 ENSMUST00000020403.7 cysteine and glycine-rich protein 2 (from RefSeq NM_007792.4) CSRP2_MOUSE Dlp1 ENSMUST00000020403.1 ENSMUST00000020403.2 ENSMUST00000020403.3 ENSMUST00000020403.4 ENSMUST00000020403.5 ENSMUST00000020403.6 NM_007792 P97314 Q9CZG5 uc007gzs.1 uc007gzs.2 uc007gzs.3 uc007gzs.4 Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system (By similarity). Interacts with KAT14. The LIM domain 1 is necessary and sufficient for this interaction (By similarity). Interacts with GLRX3. Nucleus protein binding nucleus cytoplasm multicellular organism development actin cytoskeleton organization cell differentiation metal ion binding uc007gzs.1 uc007gzs.2 uc007gzs.3 uc007gzs.4 
ENSMUST00000020408.16 Mdm2 ENSMUST00000020408.16 transformed mouse 3T3 cell double minute 2, transcript variant 1 (from RefSeq NM_010786.4) ENSMUST00000020408.1 ENSMUST00000020408.10 ENSMUST00000020408.11 ENSMUST00000020408.12 ENSMUST00000020408.13 ENSMUST00000020408.14 ENSMUST00000020408.15 ENSMUST00000020408.2 ENSMUST00000020408.3 ENSMUST00000020408.4 ENSMUST00000020408.5 ENSMUST00000020408.6 ENSMUST00000020408.7 ENSMUST00000020408.8 ENSMUST00000020408.9 MDM2_MOUSE NM_010786 P23804 Q61040 Q64330 Q91XK7 uc007hdm.1 uc007hdm.2 uc007hdm.3 E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:15195100, PubMed:21804542). Inhibits p53/TP53- and p73/TP73- mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity). Also acts as a ubiquitin ligase E3 toward itself, ARRB1 and ARBB2 (PubMed:11588219). Permits the nuclear export of p53/TP53 (By similarity). Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein (By similarity). Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation (By similarity). Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53 (By similarity). Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways (By similarity). Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus (By similarity). Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (By similarity). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (PubMed:25088421). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (PubMed:14642282). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Interacts with p53/TP53, TP73/p73, RBL5 and RP11. Binds specifically to RNA. Can interact with RB1, E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with p53/TP53 and WWOX. Interacts with CDKN2AIP, RFWD3, USP7, PYHIN1 and RBBP6. Interacts with ARRB1 and ARRB2. Interacts with PSMA3. Found in a trimeric complex with MDM2, MDM4 and USP2. Interacts with USP2 (via N- terminus and C-terminus). Interacts with MDM4. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7. Interacts directly with DAXX and USP7. Interacts (via C-terminus) with RASSF1 isoform A (via N-terminus); the interaction is independent of TP53. Interacts with APEX1; leading to its ubiquitination and degradation. Interacts with RYBP; this inhibits ubiquitination of TP53. Identified in a complex with RYBP and p53/TP53. Also a component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in regulating p53/TP53 stabilization and activity. Binds directly both p53/TP53 and TRIM28. Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor responses with DNA damage. Interacts directly with both TRIM28 and ERBB4 in the complex. Interacts with DYRK2. Interacts with IGF1R. Interacts with TRIM13; the interaction ubiquitinates MDM2 leading to its proteasomal degradation. Interacts with SNAI1; this interaction promotes SNAI1 ubiquitination. Interacts with NOTCH1 (via intracellular domain). Interacts with FHIT. Interacts with RFFL and RNF34; the interaction stabilizes MDM2. Interacts with CDK5RAP3 and CDKN2A/ARF; form a ternary complex involved in regulation of p53/TP53. Interacts with MTA1 (By similarity). Interacts with AARB2 (PubMed:11588219). Interacts with MTBP (PubMed:10906133). Interacts with PML (PubMed:15195100). Interacts with TBRG1 (PubMed:17110379). Interacts with the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11; the interaction is direct occurs in the nucleoplasm and negatively regulates MDM2-mediated TP53 ubiquitination and degradation (PubMed:15195100, PubMed:21804542). Interacts with ADGRB1; the interaction results in inhibition of MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (PubMed:25751059). Interacts with RPL23A; this interaction may promote p53/TP53 polyubiquitination (By similarity). Interacts with NDUFS1 (PubMed:30879903). Interacts with MORN3; the interaction enhances the ubiquitination of p53/TP53 (By similarity). P23804; Q8BWG8: Arrb1; NbExp=4; IntAct=EBI-641788, EBI-641778; P23804; Q62108: Dlg4; NbExp=3; IntAct=EBI-641788, EBI-300895; P23804; O88904: Hipk1; NbExp=3; IntAct=EBI-641788, EBI-692945; P23804; Q5EBH1: Rassf5; NbExp=3; IntAct=EBI-641788, EBI-960530; P23804; Q9CXW4: Rpl11; NbExp=4; IntAct=EBI-641788, EBI-1548890; P23804; P62830: Rpl23; NbExp=2; IntAct=EBI-641788, EBI-2365752; P23804; P47962: Rpl5; NbExp=3; IntAct=EBI-641788, EBI-773940; P23804; Q8BSK8: Rps6kb1; NbExp=2; IntAct=EBI-641788, EBI-646423; P23804; P02340: Tp53; NbExp=9; IntAct=EBI-641788, EBI-474016; P23804; P62991: Ubc; NbExp=2; IntAct=EBI-641788, EBI-413074; P23804; P53350: PLK1; Xeno; NbExp=2; IntAct=EBI-641788, EBI-476768; P23804-1; O35618: Mdm4; NbExp=2; IntAct=EBI-3386476, EBI-2603376; P23804-1; P02340: Tp53; NbExp=2; IntAct=EBI-3386476, EBI-474016; P23804-2; O35618: Mdm4; NbExp=2; IntAct=EBI-3386480, EBI-2603376; Nucleus, nucleoplasm Cytoplasm Nucleus, nucleolus Nucleus Note=Colocalizes with RASSF1 isoform A in the nucleus (By similarity). Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Event=Alternative splicing, Alternative initiation; Named isoforms=2; Name=Mdm2-p90; IsoId=P23804-1; Sequence=Displayed; Name=Mdm2-p76; IsoId=P23804-2; Sequence=VSP_003215; Ubiquitously expressed at low-level throughout embryo development and in adult tissues. MDM2-p90 is much more abundant than MDM2-p76 in testis, brain, heart, and kidney, but in the thymus, spleen, and intestine, the levels of the MDM2 proteins are roughly equivalent. By UV light (PubMed:10075719). Down-regulated by NPAS4 (PubMed:25088421). Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73 and E2F1. Region II contains most of a central acidic region required for interaction with ribosomal protein L5 and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc interacts specifically with RNA whether or not zinc is present and mediates the heterooligomerization with MDM4. It is also essential for its ubiquitin ligase E3 activity toward p53 and itself. Phosphorylation on Ser-163 by SGK1 activates ubiquitination of p53/TP53. Phosphorylated at multiple sites near the RING domain by ATM upon DNA damage; this prevents oligomerization and E3 ligase processivity and impedes constitutive p53/TP53 degradation (By similarity). Autoubiquitination leads to proteasomal degradation; resulting in p53/TP53 activation it may be regulated by SFN. Also ubiquitinated by TRIM13. Deubiquitinated by USP2 leads to its accumulation and increases deubiquitination and degradation of p53/TP53. Deubiquitinated by USP7 leading to its stabilization (By similarity). Loss of Dlg4 ubiquitination. [Isoform Mdm2-p76]: Does not bind to p53. Can be produced by alternative initiation at Met-50 of isoform Mdm2-p90, but is produced more efficiently by alternative splicing. Belongs to the MDM2/MDM4 family. negative regulation of transcription from RNA polymerase II promoter blood vessel development blood vessel remodeling regulation of heart rate p53 binding heart valve development atrioventricular valve morphogenesis endocardial cushion morphogenesis ventricular septum development atrial septum development ubiquitin-protein transferase activity protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol plasma membrane ubiquitin-dependent protein catabolic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest traversing start control point of mitotic cell cycle heart development 5S rRNA binding zinc ion binding response to toxic substance response to iron ion regulation of gene expression positive regulation of gene expression negative regulation of gene expression negative regulation of protein processing negative regulation of neuron projection development protein ubiquitination nuclear body transferase activity ligase activity protein sumoylation peptidyl-lysine modification SUMO transferase activity enzyme binding protein domain specific binding ubiquitin protein ligase binding protein destabilization response to magnesium ion positive regulation of proteasomal ubiquitin-dependent protein catabolic process macromolecular complex receptor serine/threonine kinase binding protein localization to nucleus regulation of protein catabolic process response to cocaine response to drug identical protein binding peroxisome proliferator activated receptor binding ribonucleoprotein complex binding negative regulation of apoptotic process ubiquitin binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to morphine negative regulation of DNA damage response, signal transduction by p53 class mediator establishment of protein localization synapse response to ether positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of mitotic cell cycle response to antibiotic positive regulation of protein export from nucleus metal ion binding protein N-terminus binding response to steroid hormone proteolysis involved in cellular protein catabolic process protein autoubiquitination cardiac septum morphogenesis ubiquitin protein ligase activity NEDD8 ligase activity macromolecular complex assembly cellular response to hydrogen peroxide negative regulation of cell cycle arrest cellular response to antibiotic cellular response to vitamin B1 cellular response to organic substance cellular response to alkaloid cellular response to growth factor stimulus cellular response to peptide hormone stimulus cellular response to estrogen stimulus cellular response to organic cyclic compound cellular response to hypoxia cellular response to gamma radiation cellular response to UV-C cellular response to actinomycin D scaffold protein binding disordered domain specific binding negative regulation of signal transduction by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator response to formaldehyde positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration amyloid fibril formation response to water-immersion restraint stress uc007hdm.1 uc007hdm.2 uc007hdm.3 
ENSMUST00000020413.4 Zpbp ENSMUST00000020413.4 zona pellucida binding protein, transcript variant 1 (from RefSeq NM_015785.2) ENSMUST00000020413.1 ENSMUST00000020413.2 ENSMUST00000020413.3 NM_015785 Q5NC84 Q5NC84_MOUSE Zpbp uc007iae.1 uc007iae.2 uc007iae.3 uc007iae.4 Cytoplasmic vesicle, secretory vesicle, acrosome Secreted Belongs to the zona pellucida-binding protein Sp38 family. extracellular region binding of sperm to zona pellucida uc007iae.1 uc007iae.2 uc007iae.3 uc007iae.4 
ENSMUST00000020420.9 Ap3d1 ENSMUST00000020420.9 adaptor-related protein complex 3, delta 1 subunit (from RefSeq NM_007460.2) AP3D1_MOUSE Ap3d ENSMUST00000020420.1 ENSMUST00000020420.2 ENSMUST00000020420.3 ENSMUST00000020420.4 ENSMUST00000020420.5 ENSMUST00000020420.6 ENSMUST00000020420.7 ENSMUST00000020420.8 NM_007460 O54774 uc007gek.1 uc007gek.2 uc007gek.3 Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes (By similarity). Involved in process of CD8+ T-cell and NK cell degranulation (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:21998198). Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). AP- 3 associates with the BLOC-1 complex. Interacts with SLC30A2. Interacts with CLN3 (via dileucine motif); this interaction facilitates lysosomal targeting (By similarity). Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the adaptor complexes large subunit family. Golgi membrane cytoplasm Golgi apparatus trans-Golgi network protein targeting to vacuole zinc II ion transport intracellular protein transport Golgi to vacuole transport anterograde axonal transport endosome membrane protein transport membrane synaptic vesicle budding from endosome vesicle-mediated transport antigen processing and presentation membrane coat AP-3 adaptor complex axon protein localization to organelle endosome to melanosome transport terminal bouton antigen processing and presentation, exogenous lipid antigen via MHC class Ib anterograde synaptic vesicle transport synaptic vesicle membrane organization positive regulation of NK T cell differentiation regulation of sequestering of zinc ion protein localization to membrane presynapse postsynapse presynaptic endosome neurotransmitter receptor transport, postsynaptic endosome to lysosome glutamatergic synapse vesicle-mediated transport in synapse axon cytoplasm uc007gek.1 uc007gek.2 uc007gek.3 
ENSMUST00000020434.4 Glipr1l2 ENSMUST00000020434.4 GLI pathogenesis-related 1 like 2, transcript variant 1 (from RefSeq NM_026223.2) ENSMUST00000020434.1 ENSMUST00000020434.2 ENSMUST00000020434.3 GRPL2_MOUSE NM_026223 Q148R1 Q3TTM5 Q9CQ35 uc007hal.1 uc007hal.2 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQ35-1; Sequence=Displayed; Name=2; IsoId=Q9CQ35-2; Sequence=VSP_032247, VSP_032248; Belongs to the CRISP family. Sequence=BAE36300.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; molecular_function extracellular space biological_process membrane integral component of membrane uc007hal.1 uc007hal.2 
ENSMUST00000020439.11 Wif1 ENSMUST00000020439.11 Wnt inhibitory factor 1 (from RefSeq NM_011915.2) ENSMUST00000020439.1 ENSMUST00000020439.10 ENSMUST00000020439.2 ENSMUST00000020439.3 ENSMUST00000020439.4 ENSMUST00000020439.5 ENSMUST00000020439.6 ENSMUST00000020439.7 ENSMUST00000020439.8 ENSMUST00000020439.9 NM_011915 Q9WUA1 WIF1_MOUSE uc007hfj.1 uc007hfj.2 uc007hfj.3 uc007hfj.4 Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. Interacts with MYOC. Secreted. Expression highest in heart and lung. Lower in brain and eye. receptor binding extracellular region multicellular organism development cell surface Wnt signaling pathway Wnt-protein binding negative regulation of Wnt signaling pathway positive regulation of fat cell differentiation anatomical structure development uc007hfj.1 uc007hfj.2 uc007hfj.3 uc007hfj.4 
ENSMUST00000020440.7 Timm13 ENSMUST00000020440.7 translocase of inner mitochondrial membrane 13 (from RefSeq NM_013895.4) ENSMUST00000020440.1 ENSMUST00000020440.2 ENSMUST00000020440.3 ENSMUST00000020440.4 ENSMUST00000020440.5 ENSMUST00000020440.6 NM_013895 P62075 Q91VM6 Q9DC89 Q9UHL8 Q9WTL1 TIM13_MOUSE Tim13a Timm13a uc007gfi.1 uc007gfi.2 uc007gfi.3 Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8- TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9- TIMM10 70 kDa complex mediates the import of much more proteins (By similarity). Heterohexamer; composed of 3 copies of TIMM8 (TIMM8A or TIMM8B) and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side Present at high level in liver and brain, and at lower level in muscle and heart. In CNS sections, it is predominantly present in the soma and the dendritic portion of the Purkinje cells of the cerebellum, but not in the glial cells. Scattered expression also is also detected in the brain stem, olfactory bulb, substantia nigra, hippocampus and striatum (at protein level). The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). Belongs to the small Tim family. fibrillar center mitochondrion mitochondrial inner membrane mitochondrial intermembrane space protein transport membrane mitochondrial intermembrane space protein transporter complex protein import into mitochondrial inner membrane metal ion binding chaperone-mediated protein transport uc007gfi.1 uc007gfi.2 uc007gfi.3 
ENSMUST00000020441.13 Vps13d ENSMUST00000020441.13 Belongs to the VPS13 family. (from UniProt B1ART1) AK172952 B1ART1 B1ART1_MOUSE ENSMUST00000020441.1 ENSMUST00000020441.10 ENSMUST00000020441.11 ENSMUST00000020441.12 ENSMUST00000020441.2 ENSMUST00000020441.3 ENSMUST00000020441.4 ENSMUST00000020441.5 ENSMUST00000020441.6 ENSMUST00000020441.7 ENSMUST00000020441.8 ENSMUST00000020441.9 Vps13d uc290roi.1 uc290roi.2 Belongs to the VPS13 family. molecular_function cell protein targeting to vacuole mitochondrion organization extrinsic component of membrane protein retention in Golgi apparatus positive regulation of macromitophagy uc290roi.1 uc290roi.2 
ENSMUST00000020444.16 Llph ENSMUST00000020444.16 LLP homolog, long-term synaptic facilitation (Aplysia), transcript variant 1 (from RefSeq NM_025431.3) ENSMUST00000020444.1 ENSMUST00000020444.10 ENSMUST00000020444.11 ENSMUST00000020444.12 ENSMUST00000020444.13 ENSMUST00000020444.14 ENSMUST00000020444.15 ENSMUST00000020444.2 ENSMUST00000020444.3 ENSMUST00000020444.4 ENSMUST00000020444.5 ENSMUST00000020444.6 ENSMUST00000020444.7 ENSMUST00000020444.8 ENSMUST00000020444.9 LLPH_MOUSE NM_025431 Q3KQP9 Q9D945 uc007hfa.1 uc007hfa.2 uc007hfa.3 In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission. Interacts with CTCF, MYO1C and with the transcriptional machinery, including RNA polymerase II and TBP. Nucleus, nucleolus Chromosome Note=Cell-permeable protein. 22 hours after injection in the hippocampal area CA1, internalized by most cells at the injection site (PubMed:26961175). Localizes at the chromosome periphery during mitosis (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D945-1; Sequence=Displayed; Name=2; IsoId=Q9D945-2; Sequence=VSP_022719; Widely expressed, with high levels in testis and spleen and low levels in heart. In the brain, expressed in the cortex and hippocampus, and at very low levels in the cerebellum. Strongly expressed in the brain in early developmental stages. Expression gradually decreases during development, from very high levels at 13 dpc down to hardly detectable in the adult at day 20 postnatal and later on (at protein level). In the hippocampal neurons, down-regulated by sustained activity induced by increased extracellular potassium concentration for a prolonged time (2 - 5 hours) (at protein level). Belongs to the learning-associated protein family. basal RNA polymerase II transcription machinery binding protein binding nucleus chromosome nucleolus positive regulation of dendritic spine development dendrite extension uc007hfa.1 uc007hfa.2 uc007hfa.3 
ENSMUST00000020446.11 Tmbim4 ENSMUST00000020446.11 transmembrane BAX inhibitor motif containing 4 (from RefSeq NM_026617.3) ENSMUST00000020446.1 ENSMUST00000020446.10 ENSMUST00000020446.2 ENSMUST00000020446.3 ENSMUST00000020446.4 ENSMUST00000020446.5 ENSMUST00000020446.6 ENSMUST00000020446.7 ENSMUST00000020446.8 ENSMUST00000020446.9 LFG4_MOUSE Lfg4 NM_026617 Q9DA39 uc007hey.1 uc007hey.2 uc007hey.3 Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release (By similarity). Interacts with ITPR3. Golgi apparatus membrane; Multi-pass membrane protein. Belongs to the BI1 family. LFG subfamily. Golgi membrane molecular_function Golgi apparatus Golgi stack apoptotic process membrane integral component of membrane negative regulation of apoptotic process regulation of calcium-mediated signaling uc007hey.1 uc007hey.2 uc007hey.3 
ENSMUST00000020448.11 Irak3 ENSMUST00000020448.11 interleukin-1 receptor-associated kinase 3, transcript variant 3 (from RefSeq NR_152856.1) ENSMUST00000020448.1 ENSMUST00000020448.10 ENSMUST00000020448.2 ENSMUST00000020448.3 ENSMUST00000020448.4 ENSMUST00000020448.5 ENSMUST00000020448.6 ENSMUST00000020448.7 ENSMUST00000020448.8 ENSMUST00000020448.9 IRAK3_MOUSE Irak3 NR_152856 Q8C7U8 Q8CE40 Q8K1S8 Q8K4B2 uc007het.1 uc007het.2 uc007het.3 Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:12150927, PubMed:12054681, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (PubMed:12150927, PubMed:12054681). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). Monomer (By similarity). Homodimer (By similarity). May interact with IRAK4 (when phosphorylated) (By similarity). Interacts (when phosphorylated at Thr-110) with PIN1 (via WW domain) in response to IL33-mediated (but not TLR4 ligand LPS) dendritic cell stimulation (PubMed:29686383). Q8K4B2; Q8R4K2: Irak4; NbExp=7; IntAct=EBI-646179, EBI-3842721; Q8K4B2; P70196: Traf6; NbExp=3; IntAct=EBI-646179, EBI-448028; Q8K4B2; Q9NWZ3: IRAK4; Xeno; NbExp=4; IntAct=EBI-646179, EBI-448378; Cytoplasm Nucleus Note=In dendritic cells, translocates into the nucleus upon IL33 stimulation. Expressed in inflamed lung macrophages (at protein level) (PubMed:29686383). Expressed in dendritic cells (at protein level) (PubMed:29686383). Highly expressed in liver and thymus and at lower levels in heart, brain, spleen and kidney (PubMed:12054681). The nucleotide binding domain binds ATP with low affinity. In response to intranasal administration of IL33, lung inflammation is reduced compared to wild-type and is associated with low infiltration by inflammatory cells, especially granulocytes, a severe reduction in Th2-type cytokine secretion, including Il4, Il5 and Il13 in bronchial alveolar fluids, and reduced up-regulation of Il6, Csf3, Cxcl2 and Ccl5 mRNAs. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Asn-306 is present instead of the conserved Asp which is expected to be an active site residue. Low level autophosphorylation activity has been reported in PubMed:12054681, while other authors describe this as an inactive kinase. nucleotide binding magnesium ion binding negative regulation of cytokine-mediated signaling pathway MyD88-dependent toll-like receptor signaling pathway protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm protein phosphorylation apoptotic process signal transduction response to virus positive regulation of macrophage tolerance induction negative regulation of macrophage cytokine production kinase activity phosphorylation transferase activity cytokine-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity response to peptidoglycan response to lipopolysaccharide negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway intracellular signal transduction negative regulation of protein catabolic process protein homodimerization activity regulation of apoptotic process negative regulation of protein complex disassembly regulation of protein complex disassembly response to exogenous dsRNA negative regulation of MAP kinase activity negative regulation of innate immune response protein autophosphorylation protein heterodimerization activity positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway response to interleukin-1 uc007het.1 uc007het.2 uc007het.3 
ENSMUST00000020449.12 Helb ENSMUST00000020449.12 helicase (DNA) B (from RefSeq NM_080446.2) ENSMUST00000020449.1 ENSMUST00000020449.10 ENSMUST00000020449.11 ENSMUST00000020449.2 ENSMUST00000020449.3 ENSMUST00000020449.4 ENSMUST00000020449.5 ENSMUST00000020449.6 ENSMUST00000020449.7 ENSMUST00000020449.8 ENSMUST00000020449.9 G5E835 HELB_MOUSE Helb NM_080446 Q6KAT5 Q6NVF4 Q8C930 Q9EQT8 uc007hes.1 uc007hes.2 uc007hes.3 uc007hes.4 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'- 3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress (PubMed:11557815, PubMed:7596831, PubMed:7794903). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Binds to RPA1; this interaction promotes HELB recruitment to chromatin following DNA damage. Interacts with at least two subunits of the DNA polymerase alpha complex. Interacts with CDC45. Interacts with TOPB1. Nucleus Cytoplasm Chromosome Note=Predominantly nuclear. Phosphorylation at Ser-942 by CDK2 during the G1/S transition results in its nuclear export into the cytoplasm as cells approach and progress through S phase. Following DNA damage, recruited to sites of double- strand breaks by the RPA complex. Phosphorylated at Ser-942 by CDK2 during the G1/S transition, resulting in its nuclear export into the cytoplasm. As S phase progresses, its exclusion from the nucleus promotes the activation of long-range resection. Belongs to the RecD family. HELB subfamily. Sequence=BAD21372.1; Type=Erroneous initiation; Evidence=; nucleotide binding DNA helicase activity RNA binding helicase activity ATP binding nucleus DNA replication factor A complex chromosome cytoplasm DNA replication DNA-dependent DNA replication DNA replication, synthesis of RNA primer cellular response to DNA damage stimulus hydrolase activity single-stranded DNA-dependent ATP-dependent DNA helicase activity DNA duplex unwinding site of double-strand break 5'-3' DNA helicase activity macromolecular complex binding regulation of DNA double-strand break processing negative regulation of double-strand break repair via homologous recombination uc007hes.1 uc007hes.2 uc007hes.3 uc007hes.4 
ENSMUST00000020450.4 Slc5a4a ENSMUST00000020450.4 solute carrier family 5, member 4a (from RefSeq NM_133184.2) ENSMUST00000020450.1 ENSMUST00000020450.2 ENSMUST00000020450.3 G5E836 NM_133184 Q8R479 Q9ET37 S5A4A_MOUSE Sglt3a Slc5a4a uc007fty.1 uc007fty.2 Does not function as sodium/D-glucose symporter (PubMed:22301059). Generates D-glucose-induced depolarization in a pH- dependent manner, with activity in acidic conditions (pH 5) but not neutral conditions (PubMed:22301059). Not inhibited by phlorizin. Cell membrane ; Multi-pass membrane protein Expressed in small intestine (PubMed:22301059). Expressed in kidney (PubMed:12969150). Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. glucose:sodium symporter activity plasma membrane sodium ion transport hydrogen ion transmembrane transporter activity membrane integral component of membrane transmembrane transporter activity transmembrane transport hydrogen ion transmembrane transport glucose transmembrane transport uc007fty.1 uc007fty.2 
ENSMUST00000020456.5 Tektip1 ENSMUST00000020456.5 tektin bundle interacting protein 1 (from RefSeq NM_001014836.3) A6H6Q4 B9EI87 ENSMUST00000020456.1 ENSMUST00000020456.2 ENSMUST00000020456.3 ENSMUST00000020456.4 NM_001014836 Q9D5N6 TKTI1_MOUSE Tektip1 uc007ghq.1 uc007ghq.2 uc007ghq.3 uc007ghq.4 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Located at the center of the tektin bundle where may function to recruit tektins or stabilize the bundle. Cytoplasm, cytoskeleton, cilium axoneme molecular_function cellular_component biological_process uc007ghq.1 uc007ghq.2 uc007ghq.3 uc007ghq.4 
ENSMUST00000020461.15 Nfic ENSMUST00000020461.15 nuclear factor I/C, transcript variant 1 (from RefSeq NM_008688.3) ENSMUST00000020461.1 ENSMUST00000020461.10 ENSMUST00000020461.11 ENSMUST00000020461.12 ENSMUST00000020461.13 ENSMUST00000020461.14 ENSMUST00000020461.2 ENSMUST00000020461.3 ENSMUST00000020461.4 ENSMUST00000020461.5 ENSMUST00000020461.6 ENSMUST00000020461.7 ENSMUST00000020461.8 ENSMUST00000020461.9 NFIC_MOUSE NM_008688 O09072 P70255 P70256 Q3U2I9 Q99MA3 Q99MA4 Q99MA5 Q99MA6 Q99MA7 Q99MA8 Q9R1G3 uc007ghy.1 uc007ghy.2 uc007ghy.3 Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Binds DNA as a homodimer. Nucleus. Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=C1A, C2; IsoId=P70255-1; Sequence=Displayed; Name=2; Synonyms=C1B; IsoId=P70255-2; Sequence=VSP_003557; Name=3; Synonyms=C5; IsoId=P70255-3; Sequence=VSP_007559; Name=4; Synonyms=C8; IsoId=P70255-4; Sequence=VSP_007557; Name=5; Synonyms=C9; IsoId=P70255-5; Sequence=VSP_007558; Name=6; Synonyms=C10; IsoId=P70255-6; Sequence=VSP_007556; Name=7; Synonyms=C11; IsoId=P70255-7; Sequence=VSP_007556, VSP_007559; Highest levels in skeletal muscle. Lower levels in heart, liver, kidney, lung and brain. Very low levels in testis and spleen. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Belongs to the CTF/NF-I family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding fibrillar center DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleus DNA replication regulation of transcription, DNA-templated odontogenesis of dentin-containing tooth negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc007ghy.1 uc007ghy.2 uc007ghy.3 
ENSMUST00000020463.14 Ncln ENSMUST00000020463.14 nicalin (from RefSeq NM_134009.3) ENSMUST00000020463.1 ENSMUST00000020463.10 ENSMUST00000020463.11 ENSMUST00000020463.12 ENSMUST00000020463.13 ENSMUST00000020463.2 ENSMUST00000020463.3 ENSMUST00000020463.4 ENSMUST00000020463.5 ENSMUST00000020463.6 ENSMUST00000020463.7 ENSMUST00000020463.8 ENSMUST00000020463.9 NCLN_MOUSE NM_134009 Q8C7Y4 Q8VCM8 Q9CX81 uc007gig.1 uc007gig.2 uc007gig.3 Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity). Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO1 and TMEM147. The BOS complex is part of the multi- pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex. Endoplasmic reticulum membrane ; Single-pass membrane protein Belongs to the nicastrin family. Sequence=BAB31708.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function endoplasmic reticulum endoplasmic reticulum membrane regulation of signal transduction membrane integral component of membrane macromolecular complex regulation of protein complex assembly protein stabilization regulation of protein complex stability uc007gig.1 uc007gig.2 uc007gig.3 
ENSMUST00000020478.14 Hcfc2 ENSMUST00000020478.14 host cell factor C2, transcript variant 2 (from RefSeq NM_001368720.1) ENSMUST00000020478.1 ENSMUST00000020478.10 ENSMUST00000020478.11 ENSMUST00000020478.12 ENSMUST00000020478.13 ENSMUST00000020478.2 ENSMUST00000020478.3 ENSMUST00000020478.4 ENSMUST00000020478.5 ENSMUST00000020478.6 ENSMUST00000020478.7 ENSMUST00000020478.8 ENSMUST00000020478.9 G5E837 HCFC2_MOUSE NM_001368720 Q9D968 uc007gjt.1 uc007gjt.2 uc007gjt.3 Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least composed of KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2 (By similarity). Interacts with TASOR (PubMed:31112734). Cytoplasm Nucleus Expressed in the spermatogonia, spermatocytes and ovary. Sequence=BAB24953.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter molecular_function nucleus nucleoplasm cytoplasm cytosol plasma membrane MLL1 complex uc007gjt.1 uc007gjt.2 uc007gjt.3 
ENSMUST00000020484.9 Txnrd1 ENSMUST00000020484.9 thioredoxin reductase 1, transcript variant 2 (from RefSeq NM_015762.2) ENSMUST00000020484.1 ENSMUST00000020484.2 ENSMUST00000020484.3 ENSMUST00000020484.4 ENSMUST00000020484.5 ENSMUST00000020484.6 ENSMUST00000020484.7 ENSMUST00000020484.8 NM_015762 Q3UEB7 Q3UK84 Q8CI31 Q99P49 Q9CSV5 Q9JMH6 TRXR1_MOUSE Trxr1 Txnrd1 uc007gka.1 uc007gka.2 uc007gka.3 The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms. [provided by RefSeq, May 2017]. Reduces disulfideprotein thioredoxin (Trx) to its dithiol- containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis. Also has reductase activity on hydrogen peroxide (H2O2). Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:20347; Evidence=; Reaction=H(+) + H2O2 + NADPH = 2 H2O + NADP(+); Xref=Rhea:RHEA:15173, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.11.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15174; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Homodimer. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JMH6-1; Sequence=Displayed; Name=2; IsoId=Q9JMH6-2; Sequence=VSP_031566; ISGylated. The thioredoxin reductase active site is a redox-active disulfide bond. The selenocysteine residue is also essential for catalytic activity. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. Sequence=AAH37643.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAE26918.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAE40292.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; fibrillar center mesoderm formation thioredoxin-disulfide reductase activity nucleus nucleoplasm cytoplasm mitochondrion cytosol response to oxidative stress gastrulation cell proliferation electron carrier activity positive regulation of cell death NAD(P)H oxidase activity selenocysteine metabolic process oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor electron transport chain selenate reductase activity benzene-containing compound metabolic process hydrogen peroxide catabolic process protein homodimerization activity neuronal cell body mercury ion binding cell redox homeostasis flavin adenine dinucleotide binding protein tetramerization oxidation-reduction process NADPH oxidation cellular oxidant detoxification uc007gka.1 uc007gka.2 uc007gka.3 
ENSMUST00000020485.11 Glt8d2 ENSMUST00000020485.11 glycosyltransferase 8 domain containing 2 (from RefSeq NM_029102.4) ENSMUST00000020485.1 ENSMUST00000020485.10 ENSMUST00000020485.2 ENSMUST00000020485.3 ENSMUST00000020485.4 ENSMUST00000020485.5 ENSMUST00000020485.6 ENSMUST00000020485.7 ENSMUST00000020485.8 ENSMUST00000020485.9 GL8D2_MOUSE NM_029102 Q640P4 Q9D163 uc007gjs.1 uc007gjs.2 uc007gjs.3 Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 8 family. Golgi apparatus membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups uc007gjs.1 uc007gjs.2 uc007gjs.3 
ENSMUST00000020488.9 Nopchap1 ENSMUST00000020488.9 NOP protein chaperone 1 (from RefSeq NM_026579.3) D10Wsu102e ENSMUST00000020488.1 ENSMUST00000020488.2 ENSMUST00000020488.3 ENSMUST00000020488.4 ENSMUST00000020488.5 ENSMUST00000020488.6 ENSMUST00000020488.7 ENSMUST00000020488.8 NM_026579 NOPC1_MOUSE Nopchap1 Q3TS58 Q3TV68 Q9CX66 uc007gkg.1 uc007gkg.2 uc007gkg.3 uc007gkg.4 Client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. Acts as a bridge between NOP58 and the R2TP complex via RUVBL1:RUVBL2. Interacts with NOP58, RUVBL1 and RUVBL2; the interactions are direct and NOPCHAP1 bridges the association of NOP58 with RUVBL1:RUVBL2 even in absence of snoRNAs. The interactions with RUVBL1 and RUVBL2 are disrupted upon ATP binding. Nucleus molecular_function cellular_component biological_process uc007gkg.1 uc007gkg.2 uc007gkg.3 uc007gkg.4 
ENSMUST00000020490.13 Wdr82 ENSMUST00000020490.13 WD repeat domain containing 82 (from RefSeq NM_029896.1) Cdw5 ENSMUST00000020490.1 ENSMUST00000020490.10 ENSMUST00000020490.11 ENSMUST00000020490.12 ENSMUST00000020490.2 ENSMUST00000020490.3 ENSMUST00000020490.4 ENSMUST00000020490.5 ENSMUST00000020490.6 ENSMUST00000020490.7 ENSMUST00000020490.8 ENSMUST00000020490.9 NM_029896 Q8BFQ4 Q8K2G5 Q8VEE8 WDR82_MOUSE Wdr82 uc009rjc.1 uc009rjc.2 uc009rjc.3 Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes (By similarity). Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (By similarity). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33767452). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452). Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (By similarity). Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC (By similarity). Associated with multiple protein complexes including an RNA polymerase II complex, MLL3/MLL4 complex and a chaperonin-containing TCP1 complex (By similarity). Interacts with CUL4B (PubMed:17041588). Interacts with RBBP5 and SETD1B (By similarity). Interacts with SETD1A (via RRM domain) (By similarity). Interacts with POLR2B (By similarity). Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (By similarity). Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad (By similarity). SETD1A enhances its interaction with POLR2A (By similarity). Interacts with PPP1R10/PNUTS (By similarity). Interacts with PPP1CA in the presence of PPP1R10/PNUTS (By similarity). Interacts with ZC3H4; interaction is independent of the SET1 complex and promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33767452). Nucleus Chromosome Note=Associates with chromatin (By similarity). Recruited at sites of high RNA polymerase II occupancy (PubMed:33767452). Belongs to the WD repeat SWD2 family. nuclear chromosome, telomeric region chromatin chromatin binding nucleus nucleolus histone methyltransferase complex histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex histone H3-K4 methylation PTW/PP1 phosphatase complex histone H3-K4 trimethylation uc009rjc.1 uc009rjc.2 uc009rjc.3 
ENSMUST00000020493.9 Pofut2 ENSMUST00000020493.9 protein O-fucosyltransferase 2 (from RefSeq NM_030262.3) ENSMUST00000020493.1 ENSMUST00000020493.2 ENSMUST00000020493.3 ENSMUST00000020493.4 ENSMUST00000020493.5 ENSMUST00000020493.6 ENSMUST00000020493.7 ENSMUST00000020493.8 NM_030262 OFUT2_MOUSE Q8VEM2 Q8VHI3 Q9CV66 uc007fvj.1 uc007fvj.2 uc007fvj.3 Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:20637190). O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (PubMed:20637190). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13 (By similarity). The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (PubMed:20637190). Reaction=GDP-beta-L-fucose + L-seryl-[protein] = 3-O-(alpha-L-fucosyl)- L-seryl-[protein] + GDP + H(+); Xref=Rhea:RHEA:63644, Rhea:RHEA- COMP:9863, Rhea:RHEA-COMP:17914, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:189632; EC=2.4.1.221; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63645; Evidence=; Reaction=GDP-beta-L-fucose + L-threonyl-[protein] = 3-O-(alpha-L- fucosyl)-L-threonyl-[protein] + GDP + H(+); Xref=Rhea:RHEA:70491, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:17915, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:189631; EC=2.4.1.221; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70492; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum Golgi apparatus Note=Mainly located in the endoplasmic reticulum. Null mice embryos die before 10.5 dpc. At the onset of gastrulation at 6.5 dpc, embryos are rounder and the embryonic and extra-embryonic ectoderm appears thickened and disorganized. Expression of NODAL and WNT3 is significantly expanded and/or displaced in the primitive streak as is BMP4 in the extra-embryonic ectoderm. By 7.5 dpc, embryos are unusually dense and shorter characterized by a dumb-bell appearance. There is unrestricted epithelial to mesenchymal transition (EMT) producing an abundance of mesenchymal cells. SNAIL1 expression is expanded and E-cadherin expression decreased. There is distal expansion of the proximal visceral endoderm. Belongs to the glycosyltransferase 68 family. Sequence=BC018194; Type=Frameshift; Evidence=; Name=Functional Glycomics Gateway - GTase; Note=Peptide- O-fucosyltransferase 2; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_620"; mesoderm formation endoplasmic reticulum Golgi apparatus carbohydrate metabolic process fucose metabolic process protein glycosylation fucosyltransferase activity regulation of gene expression regulation of epithelial to mesenchymal transition transferase activity transferase activity, transferring glycosyl groups fucosylation protein O-linked fucosylation peptide-O-fucosyltransferase activity regulation of secretion uc007fvj.1 uc007fvj.2 uc007fvj.3 
ENSMUST00000020496.14 Adarb1 ENSMUST00000020496.14 adenosine deaminase, RNA-specific, B1, transcript variant 4 (from RefSeq NR_021486.1) Adar2 C3TTQ1 ENSMUST00000020496.1 ENSMUST00000020496.10 ENSMUST00000020496.11 ENSMUST00000020496.12 ENSMUST00000020496.13 ENSMUST00000020496.2 ENSMUST00000020496.3 ENSMUST00000020496.4 ENSMUST00000020496.5 ENSMUST00000020496.6 ENSMUST00000020496.7 ENSMUST00000020496.8 ENSMUST00000020496.9 NR_021486 Q3UHM7 Q8K3X1 Q91ZS6 Q91ZS7 Q91ZS8 Q91ZS9 Q99MU8 RED1_MOUSE Red1 uc007fvp.1 uc007fvp.2 uc007fvp.3 uc007fvp.4 This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can inhibit cell proliferation and migration and can stimulate exocytosis. Reaction=adenosine in double-stranded RNA + H(+) + H2O = inosine in double-stranded RNA + NH4(+); Xref=Rhea:RHEA:10120, Rhea:RHEA- COMP:13885, Rhea:RHEA-COMP:13886, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.37; Name=1D-myo-inositol hexakisphosphate; Xref=ChEBI:CHEBI:58130; Evidence=; Note=Binds 1 myo-inositol hexakisphosphate (IP6) per subunit. ; Homodimer. Homodimerization is essential for its catalytic activity. Can form heterodimers with isoform 5 of ADAR/ADAR1 (By similarity). Nucleus Nucleus, nucleolus Note=Shuttles between nucleoli and the nucleoplasm. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q91ZS8-1; Sequence=Displayed; Name=2; IsoId=Q91ZS8-2; Sequence=VSP_013711; Name=3; IsoId=Q91ZS8-3; Sequence=VSP_013710, VSP_013711; Name=4; IsoId=Q91ZS8-4; Sequence=VSP_013709; Name=5; IsoId=Q91ZS8-5; Sequence=VSP_013709, VSP_013711; Name=6; IsoId=Q91ZS8-6; Sequence=VSP_041423; [Isoform 6]: Likely expressed from an alternative promoter. Contains a region highly similar to the so-called ssRNA- binding R-domain of ADARB2. RNA binding double-stranded RNA binding double-stranded RNA adenosine deaminase activity adenosine deaminase activity nucleus nucleoplasm nucleolus cytoplasm cytosol adenosine to inosine editing RNA processing mRNA processing neuromuscular synaptic transmission tRNA-specific adenosine deaminase activity negative regulation of cell proliferation base conversion or substitution editing mRNA modification hydrolase activity facial nerve morphogenesis hypoglossal nerve morphogenesis spinal cord ventral commissure morphogenesis negative regulation of cell migration multicellular organism growth protein homodimerization activity negative regulation of protein kinase activity by regulation of protein phosphorylation positive regulation of viral genome replication metal ion binding positive regulation of mRNA processing neuromuscular process controlling posture regulation of cell cycle innervation muscle tissue morphogenesis motor behavior motor neuron apoptotic process uc007fvp.1 uc007fvp.2 uc007fvp.3 uc007fvp.4 
ENSMUST00000020497.14 Aldh1l2 ENSMUST00000020497.14 aldehyde dehydrogenase 1 family, member L2 (from RefSeq NM_153543.2) AL1L2_MOUSE Aldh1l2 E9QLV8 ENSMUST00000020497.1 ENSMUST00000020497.10 ENSMUST00000020497.11 ENSMUST00000020497.12 ENSMUST00000020497.13 ENSMUST00000020497.2 ENSMUST00000020497.3 ENSMUST00000020497.4 ENSMUST00000020497.5 ENSMUST00000020497.6 ENSMUST00000020497.7 ENSMUST00000020497.8 ENSMUST00000020497.9 NM_153543 Q8K009 uc007gkh.1 uc007gkh.2 uc007gkh.3 uc007gkh.4 Mitochondrial 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide. Reaction=(6R)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8- tetrahydrofolate + CO2 + H(+) + NADPH; Xref=Rhea:RHEA:10180, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:195366; EC=1.5.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10181; Evidence=; Mitochondrion The N-terminal hydrolase domain has an NADP-independent formyltetrahydrofolate hydrolase activity, releasing formate and tetrahydrofolate. The C-terminal aldehyde dehydrogenase domain has an NADP- dependent dehydrogenase activity. It catalyzes the oxidation of formate, released by the hydrolysis of formyltetrahydrofolate, into CO2. The carrier domain is phosphopantetheinylated and uses the 4'- phosphopantetheine/4'-PP swinging arm to transfer the formyl group released by the N-terminal formyltetrahydrofolate hydrolase activity to the C-terminal aldehyde dehydrogenase domain that catalyzes its NADP- dependent oxidation into CO2. The overall NADP-dependent physiological reaction requires the 3 domains (N-terminal hydrolase, C-terminal aldehyde dehydrogenase and carrier domains) to convert formyltetrahydrofolate into tetrahydrofolate and CO2. Phosphopantetheinylation at Ser-375 by AASDHPPT is required for the formyltetrahydrofolate dehydrogenase activity. Homozygous knockout mice lacking Aldh1l2 are viable and fertile and no embryonic lethality is observed (PubMed:33168096). They do not display phenotypic differences in terms of growth, food consumption and development (PubMed:33168096). 10- formyl-THF and dihydrofolate accumulate in the liver of the knockout mice. It is associated with a decrease in levels of NADPH and ATP specifically in the mitochondrion (PubMed:33168096). Male knockout mice accumulate more fats in the liver which is associated with impaired beta-oxidation of fatty acids (PubMed:33168096). In the N-terminal section; belongs to the GART family. In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. catalytic activity aldehyde dehydrogenase (NAD) activity nucleus cytoplasm mitochondrion one-carbon metabolic process biosynthetic process 10-formyltetrahydrofolate catabolic process formyltetrahydrofolate dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor hydroxymethyl-, formyl- and related transferase activity oxidation-reduction process uc007gkh.1 uc007gkh.2 uc007gkh.3 uc007gkh.4 
ENSMUST00000020500.14 Appl2 ENSMUST00000020500.14 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (from RefSeq NM_145220.2) Appl2 DP13B_MOUSE Dip13b Dip3b ENSMUST00000020500.1 ENSMUST00000020500.10 ENSMUST00000020500.11 ENSMUST00000020500.12 ENSMUST00000020500.13 ENSMUST00000020500.2 ENSMUST00000020500.3 ENSMUST00000020500.4 ENSMUST00000020500.5 ENSMUST00000020500.6 ENSMUST00000020500.7 ENSMUST00000020500.8 ENSMUST00000020500.9 NM_145220 Q8K3G9 Q99LT7 uc007gkk.1 uc007gkk.2 uc007gkk.3 uc007gkk.4 Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:25568335, PubMed:27219021, PubMed:25328665, PubMed:19661063, PubMed:29467283). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses (PubMed:25568335, PubMed:27219021, PubMed:25328665). In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling (PubMed:25568335). In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines (PubMed:27219021). Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (PubMed:25328665). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (By similarity). Plays a role in cell metabolism by regulating adiponectin and insulin signaling pathways and adaptative thermogenesis (PubMed:19661063, PubMed:29467283) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (PubMed:19661063). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (By similarity). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (PubMed:29467283). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:28965332, PubMed:29675572, PubMed:26445298). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2- mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (By similarity). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor (PubMed:28965332, PubMed:29675572). Required for fibroblast migration through HGF cell signaling (PubMed:26445298). Homodimer. Homotetramer (By similarity). Binds RAB5A/Rab5 through an N-terminal domain (PubMed:25568335). This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds subunits of the NuRD/MeCP1 complex (By similarity). Interacts with FSHR; interaction is independent of follicle stimulating hormone stimulation (By similarity). Interacts with APPL1; the interaction is decreased by adiponectin in a time- dependent manner (PubMed:19661063, PubMed:25328665). Forms a complex comprising APPL1, RUVBL2, CTNNB1, HDAC1 and HDAC2; interaction reduces interaction between CTNNB1, HDAC1, HDAC2 and RUVBL2 leading to the decrease of deacetylase activity of this complex; affects the recruitment of repressive complexes to the Wnt target genes (By similarity). Interacts (via BAR domain) with TBC1D1; interaction is dependent of TBC1D1 phosphorylation at 'Ser-235'; interaction diminishes the phosphorylation of TBC1D1 at 'Thr-596', resulting in inhibition of SLC2A4 translocation and glucose uptake (PubMed:24879834). Interacts with ANXA2; targets APPL2 to endosomes and acting in parallel to RAB5A (By similarity). Interacts with RAB31 (in GTP-bound form); interaction contributes to or enhances recruitment of APPL2 to the phagosomes; interaction enhances Fc-gamma receptor- mediated phagocytosis through PI3K/Akt signaling in macrophages (PubMed:25568335). Interacts with PIK3R1; forms a complex with PIK3R1 and APPL1 (PubMed:25328665). Interacts (via BAR domain) with ADIPOR1; hinders the accessibility of APPL1 to ADIPOR1; negatively regulates adiponectin signaling; ADIPOQ dissociates this interaction and facilitates the recruitment of APPL1 to ADIPOR1 (PubMed:19661063). Interacts (via BAR domain) with ADIPOR2; ADIPOQ dissociates this interaction (PubMed:19661063). Q8K3G9; Q60949: Tbc1d1; NbExp=2; IntAct=EBI-647007, EBI-21012140; Early endosome membrane ; Peripheral membrane protein Nucleus Cell membrane Endosome membrane Cytoplasm toplasmic vesicle, phagosome Cell projection, ruffle Cell projection, ruffle membrane Cell membrane Cytoplasmic vesicle, phagosome membrane Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF (By similarity). Associates dynamically with cytoplasmic membrane structures that undergo changes in shape, movement, fusion and fission events. PI(4,5)P2 levels are important for membrane association of APPL2 (By similarity). Absent of endosome in macrophage. Colocalized with RAB31 at early-stage phagosome (PubMed:25568335). Localized on macropinosomes in LPS-activated macrophages. Associated with membrane domains in contact with pathogens and pathogen-derived ligands like LPS. First recruited to the ruffles, and accumulates on macropinosomes (PubMed:27219021). Expressed in insulin-target tissues including skeletal muscle, liver, fat, and brain. Highly expressed in kidney and pancreas (PubMed:19661063). Abundantly expressed in the ventromedial hypothalamus (VMH), barely detectable in the arcuate nucleus (ARC) and paraventricular nucleus (PVN) of the hypothalamus. Also expressed in pancreatic beta-cells (PubMed:29467283). Decreases steadily in response to lipopolysaccharide (LPS). The BAR domain is necessary and sufficient for mediating homotypic and heterotypic interactions; associates with cytoplasmic membrane structures; mediates interaction with TBC1D1 and ADIPOR1 (PubMed:24879834, PubMed:19661063). The PH and PID domains mediate phosphoinositide binding. The PID domain mediates phosphatidylserine binding and allows localization to cytosolic membrane structures and nucleus. The PH domain allows localization to the plasma membrane, cytosolic vesicles and distinct nuclear and perinuclear structures and is sufficient for RUVBL2 interaction (By similarity). Mice have normal food intake, body weight, and fasting glucose and insulin levels (PubMed:24879834). Mice are viable and grow normally to adulthood (PubMed:26445298). Appl1 and Appl2 double knockout mice are viable and grossly normal with regard to reproductive potential and postnatal growth (PubMed:26445298). Reduced survival rate after injection of LPS (PubMed:25328665). Conditional knockout mice Appl2 in pancreatic beta-cells and/or ventromedial hypothalamus (VMH) have no obvious effect on circulating level of insulin, body weight, food intake, respiratory exchange ratio (RER), and locomotor activity, but gradually increased adiposity and diminished energy expenditure. Mice exhibit cold intolerance and impairment of cold-induced thermogenesis, beiging program, and SNS outflow in subcutaneous white adipose tissue (sWAT). Conditional knockout mice Appl2 in ventromedial hypothalamus (VMH) have the same phenotype as above (PubMed:29467283). ruffle phosphatidylserine binding diet induced thermogenesis protein binding nucleus cytoplasm endosome plasma membrane protein import into nucleus cell cycle transforming growth factor beta receptor signaling pathway cell proliferation cold acclimation endosome membrane regulation of fibroblast migration membrane Rab GTPase binding signaling phagocytic vesicle membrane cytoplasmic vesicle early endosome membrane vesicle early phagosome ruffle membrane adiponectin-activated signaling pathway regulation of toll-like receptor 4 signaling pathway phosphatidylinositol binding cellular response to hepatocyte growth factor stimulus early phagosome membrane glucose homeostasis protein homodimerization activity cell projection macropinosome macromolecular complex binding regulation of innate immune response phagocytic vesicle negative regulation of fatty acid oxidation negative regulation of glucose import negative regulation of neurogenesis protein homotetramerization positive regulation of phagocytosis, engulfment negative regulation of cytokine production involved in inflammatory response negative regulation of cellular response to insulin stimulus positive regulation of macropinocytosis positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis negative regulation of neural precursor cell proliferation uc007gkk.1 uc007gkk.2 uc007gkk.3 uc007gkk.4 
ENSMUST00000020501.15 Sumo3 ENSMUST00000020501.15 small ubiquitin-like modifier 3, transcript variant 5 (from RefSeq NR_125904.1) ENSMUST00000020501.1 ENSMUST00000020501.10 ENSMUST00000020501.11 ENSMUST00000020501.12 ENSMUST00000020501.13 ENSMUST00000020501.14 ENSMUST00000020501.2 ENSMUST00000020501.3 ENSMUST00000020501.4 ENSMUST00000020501.5 ENSMUST00000020501.6 ENSMUST00000020501.7 ENSMUST00000020501.8 ENSMUST00000020501.9 NR_125904 Q14C17 Q3TBL9 Q3UDI5 Q9Z172 SUMO3_MOUSE Smt3a Smt3h1 Sumo3 uc007fvy.1 uc007fvy.2 uc007fvy.3 This gene encodes a member of the small ubiquitin-like modifier family. The encoded protein may regulate a variety of proteins in many pathways via a post-translational modification, known as SUMOylation. This activity may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Disruption of some of these processes has been associated with cerebral ischemia, neural dysfunction, and heart disease. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity). Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity (By similarity). Interacts with BMAL1. Cytoplasm Nucleus Nucleus, PML body Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z172-1; Sequence=Displayed; Name=2; IsoId=Q9Z172-2; Sequence=VSP_021948; Polymeric chains can be formed through Lys-11 cross-linking. Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function. Belongs to the ubiquitin family. SUMO subfamily. nucleus nucleoplasm cytoplasm nuclear body PML body protein sumoylation SUMO transferase activity enzyme binding protein localization to nucleus negative regulation of DNA binding positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc007fvy.1 uc007fvy.2 uc007fvy.3 
ENSMUST00000020502.9 Slc36a3 ENSMUST00000020502.9 solute carrier family 36 (proton/amino acid symporter), member 3, transcript variant 1 (from RefSeq NM_172258.4) ENSMUST00000020502.1 ENSMUST00000020502.2 ENSMUST00000020502.3 ENSMUST00000020502.4 ENSMUST00000020502.5 ENSMUST00000020502.6 ENSMUST00000020502.7 ENSMUST00000020502.8 NM_172258 Pat3 Q811P0 Q8CH37 S36A3_MOUSE Tramd2 uc007iyx.1 uc007iyx.2 uc007iyx.3 Membrane ; Multi-pass membrane protein Specifically expressed in testis. Belongs to the amino acid/polyamine transporter 2 family. amino acid transmembrane transport hydrogen:amino acid symporter activity hydrogen ion transmembrane transporter activity amino acid transmembrane transporter activity L-alanine transmembrane transporter activity glycine transmembrane transporter activity L-proline transmembrane transporter activity L-alanine transport glycine transport membrane integral component of membrane proline transmembrane transport hydrogen ion transmembrane transport uc007iyx.1 uc007iyx.2 uc007iyx.3 
ENSMUST00000020504.6 Hint1 ENSMUST00000020504.6 histidine triad nucleotide binding protein 1 (from RefSeq NM_008248.3) ENSMUST00000020504.1 ENSMUST00000020504.2 ENSMUST00000020504.3 ENSMUST00000020504.4 ENSMUST00000020504.5 HINT1_MOUSE Hint NM_008248 P70349 Pkci Pkci1 Prkcnh1 uc007iyj.1 uc007iyj.2 uc007iyj.3 Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP- morpholidate) (By similarity). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N- alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N- alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (By similarity). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O- phosphates with concomitant release of hydrogen sulfide (By similarity). In addition, functions as a scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (By similarity). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RANGAP1 and RGS17 (PubMed:31088288). Reaction=adenosine 5'-phosphoramidate + H2O = AMP + NH4(+); Xref=Rhea:RHEA:67916, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57890, ChEBI:CHEBI:456215; Evidence=; Desumoylase activity is inhibited by zinc ions, and inhibition is released by nitric oxide or calcium-activated calmodulin. Homodimer (By similarity). Interacts with CDK7 (By similarity). Interacts with RUVBL1 and RUVBL2 and is associated with the LEF1/TCF1-CTNNB1 complex and with a KAT5 histone acetyltransferase complex (By similarity). Identified in a complex with MITF and CTNNB1 (By similarity). Interacts with CDC34 and RBX1, and is part of a SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Interacts with SUMO1, SUMO2 and RGS17 (PubMed:31088288). Interacts with the Ten-1 ICD form of TENM1 (PubMed:31088288). Interacts with CALM1; interaction increases in the presence of calcium ions (PubMed:31088288). Cytoplasm Nucleus No visible phenotype. Mice display increased susceptibility to carcinogens. Belongs to the HINT family. Was originally thought to be a protein kinase C inhibitor and to bind zinc in solution. Both seem to be incorrect. histone deacetylase complex nucleotide binding catalytic activity nucleus cytoplasm cytosol plasma membrane regulation of transcription, DNA-templated apoptotic process purine ribonucleotide catabolic process hydrolase activity positive regulation of calcium-mediated signaling intrinsic apoptotic signaling pathway by p53 class mediator uc007iyj.1 uc007iyj.2 uc007iyj.3 
ENSMUST00000020507.8 Fgf18 ENSMUST00000020507.8 fibroblast growth factor 18, transcript variant 2 (from RefSeq NR_102395.1) ENSMUST00000020507.1 ENSMUST00000020507.2 ENSMUST00000020507.3 ENSMUST00000020507.4 ENSMUST00000020507.5 ENSMUST00000020507.6 ENSMUST00000020507.7 FGF18_MOUSE NR_102395 O89101 uc007ikc.1 uc007ikc.2 uc007ikc.3 uc007ikc.4 uc007ikc.5 Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation (By similarity). Interacts with FGFR3 and FGFR4. Secreted Belongs to the heparin-binding growth factors family. ossification angiogenesis intramembranous ossification endochondral ossification chondrocyte development fibroblast growth factor receptor binding type 1 fibroblast growth factor receptor binding type 2 fibroblast growth factor receptor binding extracellular region nucleus nucleolus cytoplasm signal transduction nervous system development growth factor activity cell proliferation positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway lung development positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of chondrocyte differentiation positive regulation of MAP kinase activity positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis positive regulation of ERK1 and ERK2 cascade positive regulation of endothelial cell chemotaxis to fibroblast growth factor uc007ikc.1 uc007ikc.2 uc007ikc.3 uc007ikc.4 uc007ikc.5 
ENSMUST00000020508.4 Smim23 ENSMUST00000020508.4 small integral membrane protein 23 (from RefSeq NM_027050.1) ENSMUST00000020508.1 ENSMUST00000020508.2 ENSMUST00000020508.3 NM_027050 Q9DAL0 SIM23_MOUSE uc007ikb.1 uc007ikb.2 uc007ikb.3 uc007ikb.4 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007ikb.1 uc007ikb.2 uc007ikb.3 uc007ikb.4 
ENSMUST00000020513.10 Papolg ENSMUST00000020513.10 poly(A) polymerase gamma (from RefSeq NM_172555.2) ENSMUST00000020513.1 ENSMUST00000020513.2 ENSMUST00000020513.3 ENSMUST00000020513.4 ENSMUST00000020513.5 ENSMUST00000020513.6 ENSMUST00000020513.7 ENSMUST00000020513.8 ENSMUST00000020513.9 NM_172555 PAPOG_MOUSE Q6PCL9 Q8BZC9 uc007ifp.1 uc007ifp.2 uc007ifp.3 uc007ifp.4 Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, ChEBI:CHEBI:173115; EC=2.7.7.19; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium ions. Also active with manganese. ; Nucleus Belongs to the poly(A) polymerase family. nucleotide binding RNA binding polynucleotide adenylyltransferase activity ATP binding nucleus nucleoplasm cytosol mRNA polyadenylation mRNA processing nuclear body transferase activity nucleotidyltransferase activity RNA 3'-end processing RNA polyadenylation metal ion binding uc007ifp.1 uc007ifp.2 uc007ifp.3 uc007ifp.4 
ENSMUST00000020522.9 Pfkl ENSMUST00000020522.9 phosphofructokinase, liver, B-type, transcript variant 1 (from RefSeq NM_008826.5) ENSMUST00000020522.1 ENSMUST00000020522.2 ENSMUST00000020522.3 ENSMUST00000020522.4 ENSMUST00000020522.5 ENSMUST00000020522.6 ENSMUST00000020522.7 ENSMUST00000020522.8 NM_008826 P12382 PFKAL_MOUSE Pfk-l Pfkb Pfkl Q8VDX7 uc007fwo.1 uc007fwo.2 uc007fwo.3 uc007fwo.4 uc007fwo.5 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (PubMed:26194095). Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6- bisphosphate + H(+); Xref=Rhea:RHEA:16109, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:32966, ChEBI:CHEBI:57634, ChEBI:CHEBI:456216; EC=2.7.1.11; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate. GlcNAcylation by OGT overcomes allosteric regulation (By similarity). Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 3/4. Homo- and heterotetramers (By similarity). Phosphofructokinase (PFK) enzyme functions as a tetramer composed of different combinations of 3 types of subunits, called PFKM (M), PFKL (L) and PFKP (P). The composition of the PFK tetramer differs according to the tissue type it is present in. The kinetic and regulatory properties of the tetrameric enzyme are dependent on the subunit composition, hence can vary across tissues (Probable). Cytoplasm GlcNAcylation at Ser-529 by OGT decreases enzyme activity, leading to redirect glucose flux through the oxidative pentose phosphate pathway. Glycosylation is stimulated by both hypoxia and glucose deprivation (By similarity). Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. nucleotide binding catalytic activity 6-phosphofructokinase activity ATP binding cytoplasm cytosol 6-phosphofructokinase complex carbohydrate metabolic process fructose 6-phosphate metabolic process glucose catabolic process glycolytic process metabolic process response to glucose membrane AMP binding kinase activity phosphorylation transferase activity kinase binding fructose 1,6-bisphosphate metabolic process identical protein binding negative regulation of insulin secretion metal ion binding monosaccharide binding protein oligomerization protein homotetramerization glycolytic process through fructose-6-phosphate canonical glycolysis fructose binding fructose-6-phosphate binding uc007fwo.1 uc007fwo.2 uc007fwo.3 uc007fwo.4 uc007fwo.5 
ENSMUST00000020523.4 Pex13 ENSMUST00000020523.4 peroxisomal biogenesis factor 13, transcript variant 1 (from RefSeq NM_023651.5) ENSMUST00000020523.1 ENSMUST00000020523.2 ENSMUST00000020523.3 NM_023651 PEX13_MOUSE Pex13 Q3U5T1 Q8CCJ5 Q8CCW5 Q99MM2 Q9D0K1 Q9EPK1 uc007ifj.1 uc007ifj.2 uc007ifj.3 Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Involved in the import of PTS1- and PTS2-type containing proteins (By similarity). Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex. Interacts with PEX19. Peroxisome membrane ; Multi-pass membrane protein Belongs to the peroxin-13 family. peroxisome targeting sequence binding fatty acid alpha-oxidation neuron migration suckling behavior peroxisome peroxisomal membrane integral component of peroxisomal membrane locomotory behavior protein transport membrane integral component of membrane protein import into peroxisome matrix, docking cerebral cortex cell migration intracellular membrane-bounded organelle microtubule-based peroxisome localization peroxisomal importomer complex uc007ifj.1 uc007ifj.2 uc007ifj.3 
ENSMUST00000020524.15 Rhbdf1 ENSMUST00000020524.15 rhomboid 5 homolog 1, transcript variant 1 (from RefSeq NM_010117.2) A2AVE2 Dist1 ENSMUST00000020524.1 ENSMUST00000020524.10 ENSMUST00000020524.11 ENSMUST00000020524.12 ENSMUST00000020524.13 ENSMUST00000020524.14 ENSMUST00000020524.2 ENSMUST00000020524.3 ENSMUST00000020524.4 ENSMUST00000020524.5 ENSMUST00000020524.6 ENSMUST00000020524.7 ENSMUST00000020524.8 ENSMUST00000020524.9 Irhom1 Kiaa4242 NM_010117 Q04843 Q5DTF4 Q6PIX5 Q6PJ49 Q8VIK0 RHDF1_MOUSE uc007ijb.1 uc007ijb.2 uc007ijb.3 uc007ijb.4 Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. Homodimer, or homooligomer. Interacts with TGFA and HBEGF (By similarity). Interacts with EGF; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (PubMed:21439629). Interacts (via cytoplasmic N-terminus) with FRMD8/iTAP; this interaction leads to mutual protein stabilization (By similarity). Interacts with ADAM17/TACE (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Note=Predominantly localized in the endoplasmic reticulum membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PIX5-1; Sequence=Displayed; Name=2; IsoId=Q6PIX5-2; Sequence=VSP_034190, VSP_034191; Expressed in the duodenum, as well as in fetal liver and head. Belongs to the peptidase S54 family. Sequence=AAA02574.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAL32367.1; Type=Erroneous gene model prediction; Evidence=; Sequence=BAD90543.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus proteolysis cell proliferation membrane integral component of membrane cell migration regulation of epidermal growth factor receptor signaling pathway regulation of protein secretion negative regulation of protein secretion regulation of proteasomal protein catabolic process serine-type endopeptidase activity uc007ijb.1 uc007ijb.2 uc007ijb.3 uc007ijb.4 
ENSMUST00000020527.13 1700093K21Rik ENSMUST00000020527.13 RIKEN cDNA 1700093K21 gene, transcript variant 1 (from RefSeq NM_026105.5) 1700093K21Rik A0A6Q6PKH4 A0A6Q6PKH4_MOUSE ENSMUST00000020527.1 ENSMUST00000020527.10 ENSMUST00000020527.11 ENSMUST00000020527.12 ENSMUST00000020527.2 ENSMUST00000020527.3 ENSMUST00000020527.4 ENSMUST00000020527.5 ENSMUST00000020527.6 ENSMUST00000020527.7 ENSMUST00000020527.8 ENSMUST00000020527.9 NM_026105 uc007ife.1 uc007ife.2 uc007ife.3 uc007ife.1 uc007ife.2 uc007ife.3 
ENSMUST00000020528.14 Mpg ENSMUST00000020528.14 N-methylpurine-DNA glycosylase (from RefSeq NM_010822.3) 3MG_MOUSE A2AVE7 ENSMUST00000020528.1 ENSMUST00000020528.10 ENSMUST00000020528.11 ENSMUST00000020528.12 ENSMUST00000020528.13 ENSMUST00000020528.2 ENSMUST00000020528.3 ENSMUST00000020528.4 ENSMUST00000020528.5 ENSMUST00000020528.6 ENSMUST00000020528.7 ENSMUST00000020528.8 ENSMUST00000020528.9 Mid1 NM_010822 Q04841 Q64182 uc007ijd.1 uc007ijd.2 uc007ijd.3 uc007ijd.4 Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. Reaction=Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3- methylguanine, 7-methylguanine and 7-methyladenine.; EC=3.2.2.21; Binding to SSBP1 in mitochondria inhibits glycosylase activity in the context of a single-stranded DNA (ssDNA), but not a double-stranded DNA (dsDNA) substrates. Binds MBD1. Binds SSBP1. Cytoplasm Mitochondrion matrix, mitochondrion nucleoid Nucleus Belongs to the DNA glycosylase MPG family. DNA binding catalytic activity alkylbase DNA N-glycosylase activity nucleus cytoplasm mitochondrion DNA repair base-excision repair cellular response to DNA damage stimulus DNA-3-methyladenine glycosylase activity hydrolase activity mitochondrial nucleoid DNA-7-methylguanine glycosylase activity DNA-7-methyladenine glycosylase activity DNA-3-methylguanine glycosylase activity uc007ijd.1 uc007ijd.2 uc007ijd.3 uc007ijd.4 
ENSMUST00000020529.13 Ahsa2 ENSMUST00000020529.13 AHA1, activator of heat shock protein ATPase 2, transcript variant 1 (from RefSeq NM_172391.4) AHSA2_MOUSE ENSMUST00000020529.1 ENSMUST00000020529.10 ENSMUST00000020529.11 ENSMUST00000020529.12 ENSMUST00000020529.2 ENSMUST00000020529.3 ENSMUST00000020529.4 ENSMUST00000020529.5 ENSMUST00000020529.6 ENSMUST00000020529.7 ENSMUST00000020529.8 ENSMUST00000020529.9 NM_172391 Q0P626 Q6P3F2 Q7TMW7 Q8CBI4 Q8N9S3 uc007ifb.1 uc007ifb.2 uc007ifb.3 uc007ifb.4 Co-chaperone that stimulates HSP90 ATPase activity. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N9S3-1; Sequence=Displayed; Name=2; IsoId=Q8N9S3-2; Sequence=VSP_030572; Name=3; IsoId=Q8N9S3-3; Sequence=VSP_030573; Belongs to the AHA1 family. Sequence=AAH38397.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ATPase activator activity molecular_function cellular_component biological_process positive regulation of ATPase activity chaperone binding Hsp90 protein binding uc007ifb.1 uc007ifb.2 uc007ifb.3 uc007ifb.4 
ENSMUST00000020530.12 Nprl3 ENSMUST00000020530.12 nitrogen permease regulator-like 3, transcript variant 2 (from RefSeq NM_181569.3) ENSMUST00000020530.1 ENSMUST00000020530.10 ENSMUST00000020530.11 ENSMUST00000020530.2 ENSMUST00000020530.3 ENSMUST00000020530.4 ENSMUST00000020530.5 ENSMUST00000020530.6 ENSMUST00000020530.7 ENSMUST00000020530.8 ENSMUST00000020530.9 Mare NM_181569 NPRL3_MOUSE Nprl3 Q8VIJ8 uc007ijf.1 uc007ijf.2 uc007ijf.3 As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway. In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid- sensing branch of the TORC1 pathway. Within the GATOR complex, component of the GATOR1 subcomplex, made of DEPDC5, NPRL2 and NPRL3. GATOR1 mediates the strong interaction of the GATOR complex with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) heterodimers. GATOR1 interacts with GPR155/LYCHOS; interaction takes place in presence of cholesterol and prevents interaction between GATOR1 and KICSTOR. Lysosome membrane Note=Localization to lysosomes is mediated by the KICSTOR complex and is amino acid-independent. Lethality towards the end of gestation caused by a range of cardiac defects, including outflow tract abnormalities and ventricular-septal defects. Belongs to the NPR3 family. ventricular septum development GTPase activator activity lysosome lysosomal membrane membrane negative regulation of TOR signaling cellular response to amino acid starvation aorta morphogenesis TORC1 signaling positive regulation of GTPase activity cardiac muscle tissue development palate development Iml1 complex regulation of autophagosome assembly uc007ijf.1 uc007ijf.2 uc007ijf.3 
ENSMUST00000020531.9 Hba-x ENSMUST00000020531.9 hemoglobin X, alpha-like embryonic chain in Hba complex (from RefSeq NM_010405.4) ENSMUST00000020531.1 ENSMUST00000020531.2 ENSMUST00000020531.3 ENSMUST00000020531.4 ENSMUST00000020531.5 ENSMUST00000020531.6 ENSMUST00000020531.7 ENSMUST00000020531.8 Glne1 Hba-x NM_010405 Q78PA4 Q78PA4_MOUSE haemaglobin zeta chain uc007ijj.1 uc007ijj.2 uc007ijj.3 uc007ijj.4 uc007ijj.5 The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin. Belongs to the globin family. oxygen transporter activity iron ion binding hemoglobin complex oxygen transport oxygen binding heme binding metal ion binding uc007ijj.1 uc007ijj.2 uc007ijj.3 uc007ijj.4 uc007ijj.5 
ENSMUST00000020535.2 Hbq1a ENSMUST00000020535.2 hemoglobin, theta 1A (from RefSeq NM_175000.2) ENSMUST00000020535.1 Glnd2 Hbq1 Hbq1a NM_175000 Q8BYM1 Q8BYM1_MOUSE uc007ijn.1 uc007ijn.2 This gene is one of two mouse theta-globin genes found in the alpha-globin gene cluster on chromosome 11. This gene represents the T2 (or 3') theta-globin gene described in PMIDs 18245844 and 11157800, respectively. [provided by RefSeq, Apr 2009]. ##Evidence-Data-START## Transcript exon combination :: AK039049.1, BB632867.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN00849388 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Belongs to the globin family. oxygen transporter activity hemoglobin complex oxygen transport oxygen binding heme binding haptoglobin-hemoglobin complex hydrogen peroxide catabolic process organic acid binding metal ion binding cellular oxidant detoxification peroxidase activity haptoglobin binding uc007ijn.1 uc007ijn.2 
ENSMUST00000020537.9 Nsg2 ENSMUST00000020537.9 neuron specific gene family member 2, transcript variant 1 (from RefSeq NM_008741.4) ENSMUST00000020537.1 ENSMUST00000020537.2 ENSMUST00000020537.3 ENSMUST00000020537.4 ENSMUST00000020537.5 ENSMUST00000020537.6 ENSMUST00000020537.7 ENSMUST00000020537.8 NM_008741 Nsg2 Q5SS02 Q5SS02_MOUSE uc007iiw.1 uc007iiw.2 uc007iiw.3 uc007iiw.4 Belongs to the NSG family. endosome early endosome late endosome Golgi apparatus dopamine receptor signaling pathway membrane integral component of membrane dendrite clathrin light chain binding trans-Golgi network membrane lysosomal lumen clathrin coat assembly uc007iiw.1 uc007iiw.2 uc007iiw.3 uc007iiw.4 
ENSMUST00000020546.3 Stc2 ENSMUST00000020546.3 stanniocalcin 2 (from RefSeq NM_011491.3) ENSMUST00000020546.1 ENSMUST00000020546.2 NM_011491 Q5SS12 Q5SS12_MOUSE Stc2 uc007iik.1 uc007iik.2 uc007iik.3 Has an anti-hypocalcemic action on calcium and phosphate homeostasis. Homodimer; disulfide-linked. Secreted Belongs to the stanniocalcin family. hormone activity extracellular region endoplasmic reticulum cellular calcium ion homeostasis signal transduction embryo implantation negative regulation of gene expression enzyme binding heme binding response to vitamin D protein homodimerization activity response to peptide hormone decidualization regulation of hormone biosynthetic process perinuclear region of cytoplasm cellular response to hypoxia uc007iik.1 uc007iik.2 uc007iik.3 
ENSMUST00000020547.10 Vmn2r81 ENSMUST00000020547.10 vomeronasal 2, receptor 81 (from RefSeq NM_175936.2) AJ543404 EC1-V2R ENSMUST00000020547.1 ENSMUST00000020547.2 ENSMUST00000020547.3 ENSMUST00000020547.4 ENSMUST00000020547.5 ENSMUST00000020547.6 ENSMUST00000020547.7 ENSMUST00000020547.8 ENSMUST00000020547.9 NM_175936 Q80Z09 Q80Z09_MOUSE Vmn2r81 uc007fyp.1 uc007fyp.2 uc007fyp.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane neuron differentiation G-protein coupled olfactory receptor activity signaling receptor activity detection of chemical stimulus involved in sensory perception of smell positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway uc007fyp.1 uc007fyp.2 uc007fyp.3 
ENSMUST00000020549.4 Gzmm ENSMUST00000020549.4 granzyme M (lymphocyte met-ase 1), transcript variant 4 (from RefSeq NR_126325.1) ENSMUST00000020549.1 ENSMUST00000020549.2 ENSMUST00000020549.3 Gzmm LMet-1 MMET-1 NR_126325 O08643 O08643_MOUSE uc007fzj.1 uc007fzj.2 uc007fzj.3 The protein encoded by this gene is a member of a family of cytotoxic lymphocyte serine proteases called granzymes, which are expressed by cytotoxic T lymphocytes and natural killer cells. This protein belongs to a subfamily of granzymes that cleave after methionine residues. Natural killer cell development, homeostasis and cytotoxicity are normal in mice deficient for this gene, but they demonstrate increased susceptibility to murine cytomegalovirus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. T cell mediated cytotoxicity endopeptidase activity serine-type endopeptidase activity protein binding proteolysis cell death peptidase activity serine-type peptidase activity hydrolase activity uc007fzj.1 uc007fzj.2 uc007fzj.3 
ENSMUST00000020550.13 Cdc34 ENSMUST00000020550.13 cell division cycle 34, transcript variant 1 (from RefSeq NM_177613.2) ENSMUST00000020550.1 ENSMUST00000020550.10 ENSMUST00000020550.11 ENSMUST00000020550.12 ENSMUST00000020550.2 ENSMUST00000020550.3 ENSMUST00000020550.4 ENSMUST00000020550.5 ENSMUST00000020550.6 ENSMUST00000020550.7 ENSMUST00000020550.8 ENSMUST00000020550.9 NM_177613 Q505K8 Q8CFI2 UB2R1_MOUSE Ubch3 Ube2r1 uc007fzi.1 uc007fzi.2 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence= Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L- cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.24; Evidence=; CDC34-catalyzed polyubiquitin chain assembly activity is stimulated by the conjugation of NEDD8 to the CUL1 SCF E3 ligase complex subunit. Protein modification; protein ubiquitination. Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Identified in a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex together with HINT1 and RBX1. When cullin is neddylated, the interaction between the E2 and the SCF complex is strengthened (By similarity). When phosphorylated, interacts with beta- TrCP (BTRC) (By similarity). Interacts with casein kinase subunit CSNK2B. Interacts with CNTD1; this interaction regulates the cell-cycle progression (PubMed:32640224). Cytoplasm Nucleus Note=The phosphorylation of the C- terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase. The C-terminal acidic tail is required for nuclear localization and is involved in the binding to SCF E3 ligase complexes, and more specifically with the CUL1 subunit. Phosphorylated by CK2. Phosphorylation of the C-terminal tail by CK2 controls the nuclear localization. Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding protein polyubiquitination ubiquitin-protein transferase activity ATP binding nucleus cytoplasm cytosol protein monoubiquitination cell cycle protein ubiquitination nuclear speck transferase activity cellular response to interferon-beta proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of neuron apoptotic process negative regulation of cAMP-mediated signaling ubiquitin conjugating enzyme activity protein K48-linked ubiquitination positive regulation of inclusion body assembly uc007fzi.1 uc007fzi.2 
ENSMUST00000020551.13 Asb3 ENSMUST00000020551.13 ankyrin repeat and SOCS box-containing 3 (from RefSeq NM_023906.3) ASB3_MOUSE ENSMUST00000020551.1 ENSMUST00000020551.10 ENSMUST00000020551.11 ENSMUST00000020551.12 ENSMUST00000020551.2 ENSMUST00000020551.3 ENSMUST00000020551.4 ENSMUST00000020551.5 ENSMUST00000020551.6 ENSMUST00000020551.7 ENSMUST00000020551.8 ENSMUST00000020551.9 NM_023906 Q5SSV5 Q9WV72 uc007iif.1 uc007iif.2 uc007iif.3 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B (By similarity). Protein modification; protein ubiquitination. Interacts with ELOB and TNFRSF1B. Widely expressed; highest expression in testis and spleen. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Belongs to the ankyrin SOCS box (ASB) family. biological_process protein ubiquitination intracellular signal transduction uc007iif.1 uc007iif.2 uc007iif.3 
ENSMUST00000020554.8 Madcam1 ENSMUST00000020554.8 mucosal vascular addressin cell adhesion molecule 1, transcript variant 1 (from RefSeq NM_013591.3) ENSMUST00000020554.1 ENSMUST00000020554.2 ENSMUST00000020554.3 ENSMUST00000020554.4 ENSMUST00000020554.5 ENSMUST00000020554.6 ENSMUST00000020554.7 G5E838 G5E838_MOUSE Madcam1 NM_013591 uc007fzf.1 uc007fzf.2 uc007fzf.3 positive regulation of leukocyte migration cell adhesion cell-matrix adhesion integrin-mediated signaling pathway aging membrane integral component of membrane integrin binding involved in cell-matrix adhesion positive regulation of lymphocyte migration uc007fzf.1 uc007fzf.2 uc007fzf.3 
ENSMUST00000020564.7 Shc2 ENSMUST00000020564.7 SHC (Src homology 2 domain containing) transforming protein 2 (from RefSeq NM_001024539.1) ENSMUST00000020564.1 ENSMUST00000020564.2 ENSMUST00000020564.3 ENSMUST00000020564.4 ENSMUST00000020564.5 ENSMUST00000020564.6 NM_001024539 Q8BMC3 SHC2_MOUSE Sck ShcB uc007fzd.1 uc007fzd.2 uc007fzd.3 uc007fzd.4 uc007fzd.5 Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. Interacts with the Trk receptors in a phosphotyrosine- dependent manner and MEGF12. Once activated, binds to GRB2 (By similarity). Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus. The PID domain mediates binding to the TrkA receptor. Phosphorylated on tyrosine by the Trk receptors. activation of MAPK activity plasma membrane protein kinase binding receptor tyrosine kinase binding intracellular signal transduction uc007fzd.1 uc007fzd.2 uc007fzd.3 uc007fzd.4 uc007fzd.5 
ENSMUST00000020566.7 Spmap2 ENSMUST00000020566.7 sperm microtubule associated protein 2, transcript variant 1 (from RefSeq NM_011583.3) ENSMUST00000020566.1 ENSMUST00000020566.2 ENSMUST00000020566.3 ENSMUST00000020566.4 ENSMUST00000020566.5 ENSMUST00000020566.6 NM_011583 Q6P8H9 Q9JMB1 Q9QZ27 SPMA2_MOUSE Spmap2 Theg uc007fyz.1 uc007fyz.2 uc007fyz.3 May be involved (but not essential) in spermatogenesis. Interacts with CCT5. Q9JMB1; P80316: Cct5; NbExp=2; IntAct=EBI-1390549, EBI-772379; Nucleus te=Localized predominantly in the nucleus of haploid round spermatid. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Theg major, Theg 1a; IsoId=Q9JMB1-1; Sequence=Displayed; Name=2; Synonyms=Theg minor, Theg 1b; IsoId=Q9JMB1-2; Sequence=VSP_028447; Testis specific (at protein level). Specifically expressed in spermatids; Sertoli cells maintain the level of expression in spermatids. If isolated spermatids are cultivated for 16 hours alone, the expression of THEG is down-regulated. May require signals from Sertoli cells to initiate changes in its gene expression through spermatogenesis. Expression in testis detected after stage P20, when haploid germ cells appeared in testis. According to PubMed:10747865, mice lacking Theg (mutant kisimo) have virtually no spermatozoa in the lumina of seminiferous and epididymal tubules. Spermatids in the vicinity of the lumina of seminiferous tubules showed vacuolation and were occasionally phagocytosed by Sertoli cells. Elongated spermatids have abnormal or completely nonexistent flagella. No difference is seen between wild type and null mutants in the number of spermatogonia or spermatocytes. According to PubMed:12748127 null mutants appear phenotypically normal and were fertile. However, a minor but significant reduction in testes weight was observed. Morphological appearance of sperm was normal. 'Kisimo' is a Japanese word for goddess of easy delivery. protein binding nucleus cytoplasm multicellular organism development spermatogenesis cell differentiation uc007fyz.1 uc007fyz.2 uc007fyz.3 
ENSMUST00000020568.10 Wdpcp ENSMUST00000020568.10 WD repeat containing planar cell polarity effector, transcript variant 1 (from RefSeq NM_145425.3) ENSMUST00000020568.1 ENSMUST00000020568.2 ENSMUST00000020568.3 ENSMUST00000020568.4 ENSMUST00000020568.5 ENSMUST00000020568.6 ENSMUST00000020568.7 ENSMUST00000020568.8 ENSMUST00000020568.9 FRITZ_MOUSE NM_145425 Q8BRR5 Q8C456 Q91ZJ2 uc007idx.1 uc007idx.2 uc007idx.3 Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). Interacts with CPLANE1. Interacts with INTU and FUZ; FUZ, INTU and WDPCP probably form the core CPLANE (ciliogenesis and planar polarity effectors) complex. Cell membrane Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, cilium basal body Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C456-1; Sequence=Displayed; Name=2; IsoId=Q8C456-2; Sequence=VSP_032411; Y-shaped metacarpals and defects in palate and tongue morphology characteristic for a PFD syndrome phenotype. Belongs to the WD repeat fritz family. kidney development auditory receptor cell morphogenesis protein binding cytoplasm cytoskeleton plasma membrane cilium axoneme smoothened signaling pathway nervous system development regulation of fibroblast migration membrane regulation of embryonic cell shape cell projection organization septin cytoskeleton organization regulation of protein localization embryonic digit morphogenesis cell projection camera-type eye development cilium organization establishment of protein localization embryonic organ development regulation of focal adhesion assembly digestive system development palate development cilium assembly respiratory system development cardiovascular system development glomerular visceral epithelial cell migration axonemal basal plate regulation of ruffle assembly regulation of establishment of cell polarity cell cortex apical plasma membrane uc007idx.1 uc007idx.2 uc007idx.3 
ENSMUST00000020575.5 Fstl3 ENSMUST00000020575.5 follistatin-like 3 (from RefSeq NM_031380.2) ENSMUST00000020575.1 ENSMUST00000020575.2 ENSMUST00000020575.3 ENSMUST00000020575.4 FSTL3_MOUSE Flrg NM_031380 Q9EQC7 uc007fzs.1 uc007fzs.2 uc007fzs.3 uc007fzs.4 The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10 (By similarity). Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Interacts with MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN (By similarity). Secreted Nucleus Abundantly expressed in heart, lung, kidney and testis. Continuously expressed in embryonic heart. ossification kidney development fibronectin binding hematopoietic progenitor cell differentiation extracellular region extracellular space nucleus nucleoplasm Golgi apparatus regulation of transcription from RNA polymerase II promoter multicellular organism development spermatogenesis male gonad development positive regulation of cell-cell adhesion secretory granule cell differentiation lung development adrenal gland development regulation of BMP signaling pathway negative regulation of BMP signaling pathway negative regulation of activin receptor signaling pathway neuron projection terminus negative regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter activin binding cellular response to metal ion negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway uc007fzs.1 uc007fzs.2 uc007fzs.3 uc007fzs.4 
ENSMUST00000020576.8 Ccng1 ENSMUST00000020576.8 cyclin G1, transcript variant 2 (from RefSeq NR_184448.1) Ccng1 ENSMUST00000020576.1 ENSMUST00000020576.2 ENSMUST00000020576.3 ENSMUST00000020576.4 ENSMUST00000020576.5 ENSMUST00000020576.6 ENSMUST00000020576.7 NR_184448 Q5NC86 Q5NC86_MOUSE uc007ilz.1 uc007ilz.2 uc007ilz.3 May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation. Nucleus Belongs to the cyclin family. Cyclin G subfamily. regulation of cell cycle uc007ilz.1 uc007ilz.2 uc007ilz.3 
ENSMUST00000020578.11 Nudcd2 ENSMUST00000020578.11 NudC domain containing 2, transcript variant 1 (from RefSeq NM_026023.6) D11Ertd603e ENSMUST00000020578.1 ENSMUST00000020578.10 ENSMUST00000020578.2 ENSMUST00000020578.3 ENSMUST00000020578.4 ENSMUST00000020578.5 ENSMUST00000020578.6 ENSMUST00000020578.7 ENSMUST00000020578.8 ENSMUST00000020578.9 NM_026023 NUDC2_MOUSE Q8CD03 Q9CQ48 Q9CY63 Q9D0V4 uc007ily.1 uc007ily.2 uc007ily.3 uc007ily.4 uc007ily.5 May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. Interacts with LIS1. Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Note=Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis. chromosome, centromeric region kinetochore condensed chromosome kinetochore spindle pole chromosome cytoplasm microtubule organizing center cytoskeleton protein folding developmental process unfolded protein binding uc007ily.1 uc007ily.2 uc007ily.3 uc007ily.4 uc007ily.5 
ENSMUST00000020579.9 Hmmr ENSMUST00000020579.9 hyaluronan mediated motility receptor (RHAMM) (from RefSeq NM_013552.2) ENSMUST00000020579.1 ENSMUST00000020579.2 ENSMUST00000020579.3 ENSMUST00000020579.4 ENSMUST00000020579.5 ENSMUST00000020579.6 ENSMUST00000020579.7 ENSMUST00000020579.8 HMMR_MOUSE Ihabp NM_013552 Q00547 Q5NC88 Rhamm uc007ilt.1 uc007ilt.2 uc007ilt.3 uc007ilt.4 Receptor for hyaluronic acid (HA) (PubMed:1376732). Involved in cell motility (PubMed:1376732). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenesis (PubMed:22666460). Interacts with ANKRD26 (By similarity). Interacts with DYNLL1 (By similarity). Interacts with FAM83D/CHICA (By similarity). Cell surface toplasm toplasm, cytoskeleton, spindle Event=Alternative splicing; Named isoforms=2; Name=RHAMM1V4; IsoId=Q00547-1; Sequence=Displayed; Name=RHAMM1; IsoId=Q00547-2; Sequence=VSP_004287; Ubiquitously expressed. hyaluronic acid binding cytoplasm centrosome cytosol cell surface microtubule cytoskeleton uc007ilt.1 uc007ilt.2 uc007ilt.3 uc007ilt.4 
ENSMUST00000020580.13 Polrmt ENSMUST00000020580.13 polymerase (RNA) mitochondrial (DNA directed), transcript variant 10 (from RefSeq NR_176423.1) ENSMUST00000020580.1 ENSMUST00000020580.10 ENSMUST00000020580.11 ENSMUST00000020580.12 ENSMUST00000020580.2 ENSMUST00000020580.3 ENSMUST00000020580.4 ENSMUST00000020580.5 ENSMUST00000020580.6 ENSMUST00000020580.7 ENSMUST00000020580.8 ENSMUST00000020580.9 NR_176423 Polrmt Q8BJE0 Q8BKF1 RPOM_MOUSE uc007fzo.1 uc007fzo.2 uc007fzo.3 uc007fzo.4 DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Has DNA primase activity. Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging- strand DNA synthesis from the origin of light-strand DNA replication (OriL). Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA- COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.6; Evidence= Homodimer. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT. In this complex TFAM recruits POLRMT to the promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (By similarity). Upon metabolic stress, forms a complex composed of FOXO3, SIRT3 and mitochondrial RNA polymerase POLRMT; the complex is recruited to mtDNA in a SIRT3- dependent manner (PubMed:23283301). Also forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT. Interacts with TFB1M and TFB2M, leading to the stimulation of transcription. Interacts with TEFM. Interacts with MTRES1 (By similarity). Mitochondrion Belongs to the phage and mitochondrial RNA polymerase family. mitochondrial RNA polymerase regulatory region DNA binding DNA binding DNA-directed 5'-3' RNA polymerase activity protein binding mitochondrion mitochondrial matrix transcription, DNA-templated transcription from mitochondrial promoter transferase activity nucleotidyltransferase activity macromolecular complex mitochondrial DNA-directed RNA polymerase complex mitochondrial nucleoid sequence-specific DNA binding uc007fzo.1 uc007fzo.2 uc007fzo.3 uc007fzo.4 
ENSMUST00000020586.7 Slc22a4 ENSMUST00000020586.7 solute carrier family 22 (organic cation transporter), member 4, transcript variant 1 (from RefSeq NM_019687.4) ENSMUST00000020586.1 ENSMUST00000020586.2 ENSMUST00000020586.3 ENSMUST00000020586.4 ENSMUST00000020586.5 ENSMUST00000020586.6 NM_019687 Octn1 Q9Z306 S22A4_MOUSE Slc22a4 uc007ixe.1 uc007ixe.2 uc007ixe.3 Transporter that mediates the transport of endogenous and microbial zwitterions and organic cations (PubMed:11010964, PubMed:20601551, PubMed:20224991). Functions as a Na(+)-dependent and pH-dependent high affinity microbial symporter of potent food-derived antioxidant ergothioeine (By similarity). Transports one sodium ion with one ergothioeine molecule (By similarity). Involved in the absorption of ergothioneine from the luminal/apical side of the small intestine and renal tubular cells, and into non-parenchymal liver cells, thereby contributing to maintain steady-state ergothioneine level in the body (PubMed:20601551, PubMed:20224991). Also mediates the bidirectional transport of acetycholine, although the exact transport mechanism has not been fully identified yet (By similarity). Most likely exports anti-inflammatory acetylcholine in non-neuronal tissues, thereby contributing to the non-neuronal cholinergic system (By similarity). Displays a general physiological role linked to better survival by controlling inflammation and oxidative stress, which may be related to ergothioneine and acetycholine transports (PubMed:20224991). May also function as a low-affinity Na(+)-dependent transporter of L- carnitine through the mitochondrial membrane, thereby maintaining intracellular carnitine homeostasis (PubMed:11010964, PubMed:16729965). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (By similarity). Reaction=ergothioneine(out) + Na(+)(out) = ergothioneine(in) + Na(+)(in); Xref=Rhea:RHEA:75843, ChEBI:CHEBI:29101, ChEBI:CHEBI:134344; Evidence= Reaction=acetylcholine(in) = acetylcholine(out); Xref=Rhea:RHEA:74663, ChEBI:CHEBI:15355; Evidence=; Reaction=(R)-carnitine(out) + Na(+)(out) = (R)-carnitine(in) + Na(+)(in); Xref=Rhea:RHEA:72091, ChEBI:CHEBI:16347, ChEBI:CHEBI:29101; Evidence=; Reaction=glycine betaine(out) + Na(+)(out) = glycine betaine(in) + Na(+)(in); Xref=Rhea:RHEA:72115, ChEBI:CHEBI:17750, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72116; Evidence=; Allosterically activated by intracellular ATP. Kinetic parameters: KM=4.68 uM for ergothioneine (at pH 7.4) ; Vmax=531 pmol/min/mg enzyme for ergothioneine uptake (at pH 7.4) ; Interacts with PDZK1. Apical cell membrane ; Multi-pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Basal cell membrane ; Multi-pass membrane protein Note=Localized to the apical membrane of small intestines (PubMed:20601551). Localized to the apical membrane of cortical proximal tubular epithelial cells in kidney (PubMed:15832501). Expressed in kidney (PubMed:11010964, PubMed:15832501). Expressed in small intestines (PubMed:20601551). Expressed in liver in non-parenchymal liver tissue such as sinusoidal vessels (PubMed:11010964, PubMed:20601551). Weakly expressed in lung and brain (PubMed:11010964). Expressed in testis and spleen (PubMed:11010964). Expressed in heart (PubMed:16729965). Knockout mice developed normally and did not display any gross phenotypic abnormalities. Knockout mice show a complete deficiency of ergothioneine in heart, liver, small intestine, kidney and erythrocytes. Impaired intestinal absorption and renal reabsorption of ergothioneine (PubMed:20224991, PubMed:20601551). Lower tolerance to intestinal oxidative stress (PubMed:20224991). Mediates the Na(+)-independent and pH-dependent bidirectional transport of exogenous prototype organic cation tetraethylammonium (TEA). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. It is unclear whether it transports carnitine in vivo. nucleotide binding ATP binding mitochondrion triglyceride metabolic process ion transport sodium ion transport carnitine metabolic process organic cation transmembrane transporter activity carnitine transmembrane transporter activity symporter activity cation:cation antiporter activity quaternary ammonium group transmembrane transporter activity quaternary ammonium group transport carnitine transport membrane integral component of membrane apical plasma membrane transmembrane transporter activity PDZ domain binding transmembrane transport cation transmembrane transport carnitine transmembrane transport uc007ixe.1 uc007ixe.2 uc007ixe.3 
ENSMUST00000020608.3 Ppp2ca ENSMUST00000020608.3 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform (from RefSeq NM_019411.4) ENSMUST00000020608.1 ENSMUST00000020608.2 NM_019411 O88591 P13353 P63330 PP2AA_MOUSE Q5SNY5 uc007ivb.1 uc007ivb.2 uc007ivb.3 PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (By similarity). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (By similarity). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (PubMed:18084284). Can dephosphorylate p53/TP53 (By similarity). Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (By similarity). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (By similarity). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (PubMed:28465465). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (PubMed:26974206, PubMed:33505023). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (PubMed:33505023). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20630; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47005; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunitst (By similarity). Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with NXN; the interaction is direct (By similarity). Interacts with KCTD20 (PubMed:24156551). Interacts with BTBD10 (PubMed:18160256). Interacts with SGO1 and SGO2 (By similarity). Interacts with TP53 (By similarity). Interacts with AXIN1; the interaction dephosphorylates AXIN1 (By similarity). Interacts with PIM3; this interaction promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3 (By similarity). Interacts with RAF1 (By similarity). Interaction with IGBP1 protects unassembled PPP2CA from degradative ubiquitination (By similarity). Interacts with GSK3B (via C2 domain) (By similarity). Interacts with MFHAS1; retains PPP2CA into the cytoplasm and excludes it from the nucleus (By similarity). Interacts with PABIR1/FAM122A (By similarity). Interacts with ADCY8; interaction is phosphatase activity- dependent; antagonizes interaction between ADCY8 and calmodulin (PubMed:16258073). Interacts with CRTC3 (when phosphorylated at 'Ser- 391') (PubMed:30611118). Interacts with SPRY2; the interaction is inhibited by TESK1 interaction with SPRY2, possibly by vesicular sequestration of SPRY2 (By similarity). Interacts with TRAF3IP3 (By similarity). Interacts with AMBRA1 (via PxP motifs); enhancing interaction between PPP2CA and MYC or FOXO3 (PubMed:25438055). Forms a complex with AMBRA1 and BECN1; AMBRA1 and BECN1 components of the complex regulate MYC stability via different pathways (By similarity). P63330; Q61249: Igbp1; NbExp=2; IntAct=EBI-397144, EBI-7002233; P63330; Q76MZ3: Ppp2r1a; NbExp=3; IntAct=EBI-397144, EBI-400413; Cytoplasm Nucleus Chromosome, centromere Cytoplasm, cytoskeleton, spindle pole Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres (By similarity). During mitosis, also found at spindle poles (By similarity). Centromeric localization requires the presence of SGO2 (PubMed:18084284). Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (Lcmt1) and protein phosphatase methylesterase 1 (Ppme1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization. Phosphorylation of either threonine (by autophosphorylation- activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation. Polyubiquitinated, leading to its degradation by the proteasome (By similarity). May be monoubiquitinated by NOSIP (PubMed:25546391). Double mutation Phe-307 and Gln-309 results in association of the PP2A C subunit with alpha-4 protein. Belongs to the PPP phosphatase family. PP-1 subfamily. negative regulation of transcription from RNA polymerase II promoter protein phosphatase type 2A complex chromosome, centromeric region spindle pole regulation of protein phosphorylation negative regulation of protein phosphorylation phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein binding nucleus chromosome cytoplasm cytosol cytoskeleton plasma membrane protein dephosphorylation mesoderm development protein C-terminus binding response to lead ion regulation of receptor activity negative regulation of epithelial to mesenchymal transition postsynaptic density hydrolase activity enzyme binding protein kinase binding protein phosphatase binding protein domain specific binding beta-2 adrenergic receptor binding regulation of protein autophosphorylation positive regulation of phosphoprotein phosphatase activity positive regulation of protein dephosphorylation peptidyl-threonine dephosphorylation regulation of protein catabolic process negative regulation of protein import into nucleus identical protein binding neuron projection positive regulation of apoptotic process terminal bouton positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase B binding ion channel binding macromolecular complex binding membrane raft synapse metal ion binding protein heterodimerization activity tau protein binding GABA receptor binding meiotic cell cycle protein phosphatase 2A binding regulation of cell cycle cellular response to glucose stimulus positive regulation of protein serine/threonine kinase activity negative regulation of calcium ion transmembrane transporter activity positive regulation of microtubule binding protein antigen binding uc007ivb.1 uc007ivb.2 uc007ivb.3 
ENSMUST00000020617.3 Flt4 ENSMUST00000020617.3 FMS-like tyrosine kinase 4 (from RefSeq NM_008029.3) ENSMUST00000020617.1 ENSMUST00000020617.2 Flt4 NM_008029 Q5SU94 Q5SU94_MOUSE uc007iqu.1 uc007iqu.2 uc007iqu.3 uc007iqu.4 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Cell membrane ; Single-pass type I membrane protein Membrane ingle-pass type I membrane protein Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. nucleotide binding positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation lymphangiogenesis protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity ATP binding nucleoplasm plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation positive regulation of vascular endothelial growth factor production positive regulation of endothelial cell migration membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation growth factor binding protein phosphatase binding cellular response to vascular endothelial growth factor stimulus VEGF-C-activated receptor activity vascular endothelial growth factor signaling pathway protein homodimerization activity negative regulation of apoptotic process receptor complex positive regulation of MAPK cascade positive regulation of JNK cascade protein autophosphorylation vascular endothelial growth factor receptor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of protein kinase C signaling uc007iqu.1 uc007iqu.2 uc007iqu.3 uc007iqu.4 
ENSMUST00000020629.5 Gfpt2 ENSMUST00000020629.5 glutamine fructose-6-phosphate transaminase 2 (from RefSeq NM_013529.3) ENSMUST00000020629.1 ENSMUST00000020629.2 ENSMUST00000020629.3 ENSMUST00000020629.4 GFPT2_MOUSE NM_013529 Q5NCL2 Q9Z2Z9 uc011xud.1 uc011xud.2 uc011xud.3 Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6- phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985, ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=2.6.1.16; Evidence=; Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D- fructose 6-phosphate: step 1/1. glutamine-fructose-6-phosphate transaminase (isomerizing) activity fructose 6-phosphate metabolic process UDP-N-acetylglucosamine metabolic process UDP-N-acetylglucosamine biosynthetic process protein N-linked glycosylation glutamine metabolic process transaminase activity transferase activity carbohydrate derivative binding carbohydrate derivative metabolic process carbohydrate derivative biosynthetic process cellular response to leukemia inhibitory factor uc011xud.1 uc011xud.2 uc011xud.3 
ENSMUST00000020630.8 Hspa4 ENSMUST00000020630.8 heat shock protein 4 (from RefSeq NM_008300.3) ENSMUST00000020630.1 ENSMUST00000020630.2 ENSMUST00000020630.3 ENSMUST00000020630.4 ENSMUST00000020630.5 ENSMUST00000020630.6 ENSMUST00000020630.7 Hspa4 NM_008300 Q3U2G2 Q3U2G2_MOUSE uc007ivq.1 uc007ivq.2 uc007ivq.3 Interacts with TJP1/ZO-1. Cytoplasm Belongs to the heat shock protein 70 family. nucleotide binding ATP binding cytosol protein import into mitochondrial outer membrane chaperone-mediated protein complex assembly extracellular exosome uc007ivq.1 uc007ivq.2 uc007ivq.3 
ENSMUST00000020634.14 Mapk9 ENSMUST00000020634.14 mitogen-activated protein kinase 9, transcript variant alpha2 (from RefSeq NM_207692.2) ENSMUST00000020634.1 ENSMUST00000020634.10 ENSMUST00000020634.11 ENSMUST00000020634.12 ENSMUST00000020634.13 ENSMUST00000020634.2 ENSMUST00000020634.3 ENSMUST00000020634.4 ENSMUST00000020634.5 ENSMUST00000020634.6 ENSMUST00000020634.7 ENSMUST00000020634.8 ENSMUST00000020634.9 Jnk2 MK09_MOUSE NM_207692 Prkm9 Q5NCK9 Q5NCL5 Q8C097 Q8VDD2 Q9WTU4 Q9WTU5 Q9WTU6 uc007irg.1 uc007irg.2 uc007irg.3 uc007irg.4 Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro- inflammatory cytokines or physical stress stimulate the stress- activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1- specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (PubMed:29153991). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1. Interacts with MECOM (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP- 3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway (PubMed:11562351). Interacts with NFATC4 (By similarity). Interacts with ATF7; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN (By similarity). Interacts with BCL10 (By similarity). Interacts with CTNNB1 and GSK3B (By similarity). Interacts with DCLK2 (PubMed:16628014). Interacts with MAPKBP1 (By similarity). Interacts with POU5F1; phosphorylates POU5F1 at 'Ser-347' (PubMed:29153991). Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1, MAP2K7/MKK7, MAPK8IP1/JIP1 and MAPK8/JNK1 (PubMed:27084103). Cytoplasm Nucleus Note=Colocalizes with POU5F1 in the nucleus. Event=Alternative splicing; Named isoforms=4; Name=Alpha-2; IsoId=Q9WTU6-1; Sequence=Displayed; Name=Alpha-1; IsoId=Q9WTU6-2; Sequence=VSP_004837; Name=Beta-1; IsoId=Q9WTU6-3; Sequence=VSP_004836, VSP_004837; Name=Beta-2; IsoId=Q9WTU6-4; Sequence=VSP_004836; All four isoforms are widely distributed in brain. Isoforms alpha-1 and alpha-2 are predominantly expressed in hippocampus, cerebral cortex, caudate-putamen, amygdala and the granule layer of the cerebellum. Alpha-1 is more abundant than alpha-2 in the periaqueductal region and the substantia nigra. In T-cells, following T-cell receptor (TCR) activation. Levels peak 48 hours after TCR and CD-28 costimulation. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. nucleotide binding release of cytochrome c from mitochondria positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity JUN kinase activity MAP kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding nucleus cytoplasm mitochondrion cytosol protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process JNK cascade JUN phosphorylation transcription factor binding cysteine-type endopeptidase activator activity involved in apoptotic process regulation of gene expression positive regulation of gene expression positive regulation of macrophage derived foam cell differentiation positive regulation of cell morphogenesis involved in differentiation kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation neuron projection development positive regulation of prostaglandin biosynthetic process regulation of protein ubiquitination positive regulation of protein ubiquitination mitogen-activated protein kinase kinase kinase binding positive regulation of prostaglandin secretion positive regulation of chemokine production cellular response to reactive oxygen species cellular response to UV intracellular signal transduction response to drug regulation of circadian rhythm neuron projection positive regulation of apoptotic process perikaryon positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated regulation of JNK cascade response to cadmium ion rhythmic process positive regulation of nitric-oxide synthase biosynthetic process cellular response to cadmium ion positive regulation of podosome assembly positive regulation of transcription factor catabolic process positive regulation of apoptotic signaling pathway uc007irg.1 uc007irg.2 uc007irg.3 uc007irg.4 
ENSMUST00000020640.8 Rack1 ENSMUST00000020640.8 receptor for activated C kinase 1 (from RefSeq NM_008143.3) ENSMUST00000020640.1 ENSMUST00000020640.2 ENSMUST00000020640.3 ENSMUST00000020640.4 ENSMUST00000020640.5 ENSMUST00000020640.6 ENSMUST00000020640.7 Gnb2-rs1 Gnb2l1 NM_008143 P25388 P68040 P99049 Q3THP0 Q3THY7 Q3TKQ0 Q3TW88 Q5NCC5 Q5NCC6 Q9CSQ0 Q9ERM6 RACK1_MOUSE Rack1 uc007ipa.1 uc007ipa.2 uc007ipa.3 Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules (PubMed:7968370, PubMed:18258429, PubMed:20093473, PubMed:21262816, PubMed:33505023, PubMed:36517592). Interacts with a wide variety of proteins and plays a role in many cellular processes (PubMed:7968370, PubMed:18258429, PubMed:20093473, PubMed:21262816, PubMed:36517592). Component of the 40S ribosomal subunit involved in translational repression (PubMed:36517592). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation (By similarity). May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6 (By similarity). Inhibits the activity of SRC kinases including SRC, LCK and YES1 (By similarity). Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle (By similarity). Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer (PubMed:20093473). Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC (By similarity). Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix (By similarity). Involved in PKC-dependent translocation of ADAM12 to the cell membrane (By similarity). Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation (PubMed:21262816). Required for PTK2/FAK1 phosphorylation and dephosphorylation (By similarity). Regulates internalization of the muscarinic receptor CHRM2 (By similarity). Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L (By similarity). Inhibits TRPM6 channel activity (PubMed:18258429). Regulates cell surface expression of some GPCRs such as TBXA2R (By similarity). Plays a role in regulation of FLT1-mediated cell migration (By similarity). Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (By similarity). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (PubMed:33505023). Monomer; also forms homodimers and homooligomers (By similarity). Interacts with CPNE3 (By similarity). May interact with ABCB4 (By similarity). Component of the small (40S) ribosomal subunit (PubMed:36517592). Interacts with LARP4B. Interacts with LARP4. Interacts with PKD2L1 (By similarity). Binds NHERF1 (By similarity). Forms a ternary complex with TRIM63 and PRKCE (By similarity). Interacts with HABP4, KRT1 and OTUB1 (By similarity). Interacts with SRC (via SH2 domain); the interaction is enhanced by tyrosine phosphorylation of RACK1 (By similarity). Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and PRKCA (PubMed:20093473). Interacts with AR (By similarity). Interacts with IGF1R but not with INSR (By similarity). Interacts with ADAM12 (By similarity). Interacts with CLEC1B (via N-terminal region) and with HIF1A; the interaction promotes their degradation (By similarity). Interacts with RHOA; this enhances RHOA activation and promotes cell migration (By similarity). Interacts with CHRM2; the interaction regulates CHRM2 internalization (By similarity). Interacts with TRPM6 (via kinase domain) (PubMed:18258429). Interacts with PTK2/FAK1; required for PTK2/FAK1 phosphorylation and dephosphorylation (By similarity). Interacts with FLT1 (By similarity). Interacts with HRAS (By similarity). Interacts with SLC9A5; this interaction regulates SLC9A5 cell-surface targeting and SLC9A5 activity (By similarity). Interacts with SLC9A6; this interaction regulates the distribution of SLC9A6 between endosomes and the plasma membrane (By similarity). Interacts with AIM2; promoting association with PP2A phosphatase and dephosphorylation of AKT1 (PubMed:33505023). P68040; O88351: Ikbkb; NbExp=4; IntAct=EBI-296749, EBI-447960; Cell membrane ; Peripheral membrane protein Cytoplasm Cytoplasm, perinuclear region Nucleus Perikaryon Cell projection, dendrite Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. PKC activation induces translocation from the perinuclear region to the cell periphery (By similarity). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (PubMed:16414032). Strongly and ubiquitously expressed in the embryonic and early postnatal brain. At 11.5 dpc, expressed in a high- dorsal to low-ventral gradient throughout the brain. At 13.5 dpc, most abundant in the telecephalon. At 18.5 dpc, expressed most abundantly in layers 1-4 of the cortex, striatum, hippocampus, dentate gyrus, and specific thalamic nuclei. This expression decreases during postnatal development and is localized in the dentate gyrus, habenula, piriform cortex, paraventricular nucleus of the hypothalamus and supraoptic nucleus of the adult brain. Expressed throughout embryonic brain development with high levels detected at 11.5 dpc, 13.5 dpc and 18.5 dpc. Also detected at high levels in the adult brain. The 7 WD repeats mediate protein-protein interactions with binding partners. Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is required for binding to SRC (By similarity). Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. Sequence=AAG29506.1; Type=Frameshift; Evidence=; phagocytic cup positive regulation of protein phosphorylation protein kinase C binding protein binding nucleus nucleoplasm cytoplasm mitochondrion cytosol ribosome plasma membrane translation regulation of translation apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cell cycle multicellular organism development gastrulation protein localization ion channel inhibitor activity cysteine-type endopeptidase activator activity involved in apoptotic process negative regulation of gene expression small ribosomal subunit membrane protein ubiquitination negative regulation of translation enzyme binding protein phosphatase binding cytosolic small ribosomal subunit negative regulation of Wnt signaling pathway protein tyrosine kinase inhibitor activity negative regulation of cell growth cyclin binding positive regulation of cell migration dendrite midbody receptor tyrosine kinase binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein homooligomerization regulation of protein localization negative regulation of peptidyl-serine phosphorylation intracellular signal transduction signaling adaptor activity signaling receptor activity regulation of growth SH2 domain binding protein homodimerization activity cell projection positive regulation of Golgi to plasma membrane protein transport neuron projection ribosome binding neuronal cell body positive regulation of apoptotic process perikaryon pigmentation positive regulation of GTPase activity cell body perinuclear region of cytoplasm rhythmic process negative regulation of phagocytosis regulation of cell division positive regulation of cyclic-nucleotide phosphodiesterase activity regulation of cell cycle negative regulation of protein kinase B signaling positive regulation of mitochondrial depolarization negative regulation of protein tyrosine kinase activity cellular response to glucose stimulus cellular response to growth factor stimulus rescue of stalled ribosome regulation of protein localization to plasma membrane negative regulation of hydrogen peroxide-induced neuron death IRE1-RACK1-PP2A complex regulation of establishment of cell polarity positive regulation of gastrulation positive regulation of intrinsic apoptotic signaling pathway uc007ipa.1 uc007ipa.2 uc007ipa.3 
ENSMUST00000020643.4 Rufy1 ENSMUST00000020643.4 RUN and FYVE domain containing 1 (from RefSeq NM_172557.3) ENSMUST00000020643.1 ENSMUST00000020643.2 ENSMUST00000020643.3 NM_172557 Q8BIJ7 Q8BKQ4 Q8BL21 Q9EPM6 RUFY1_MOUSE Rabip4 uc007isn.1 uc007isn.2 uc007isn.3 Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. Interacts with BMX. May interact with SSB (By similarity). Interacts with RAB4 and RAB5 that have been activated by GTP-binding. Cytoplasm. Early endosome membrane; Peripheral membrane protein. Broadly expressed. The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions (By similarity). Phosphorylation on Tyr-393 and/or Tyr-404 is required for interaction with BMX and endosomal targeting. Sequence=CAC17732.1; Type=Erroneous initiation; Evidence=; protein binding nucleus cytoplasm endosome endocytosis small GTPase mediated signal transduction lipid binding protein transport membrane nuclear speck SH3 domain binding regulation of endocytosis early endosome membrane SH2 domain binding intracellular membrane-bounded organelle metal ion binding late endosome cytosol uc007isn.1 uc007isn.2 uc007isn.3 
ENSMUST00000020647.10 Mrnip ENSMUST00000020647.10 MRN complex interacting protein (from RefSeq NM_026543.3) ENSMUST00000020647.1 ENSMUST00000020647.2 ENSMUST00000020647.3 ENSMUST00000020647.4 ENSMUST00000020647.5 ENSMUST00000020647.6 ENSMUST00000020647.7 ENSMUST00000020647.8 ENSMUST00000020647.9 MRNIP_MOUSE Mrnip NM_026543 Q9CX85 Q9D1F5 uc007irv.1 uc007irv.2 uc007irv.3 uc007irv.4 Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair. Associates with the MRE11-RAD50-NBN (MRN) damage-sensing complex; this association is constitutive. Interacts with MRE11. Interacts with NBN. Interacts with RAD50. Nucleus Nucleus, nucleoplasm Note=Recruited to sites of DNA damage. Phosphorylation induces its nuclear localization and promotes genome stability. Phosphorylated; phosphorylation is constitutive and occurs in the absence of any DNA-damaging stimulus. Phosphorylation is necessary for its nuclear retention. Belongs to the MRNIP family. molecular_function chromatin binding cellular_component nucleus nucleoplasm DNA repair cellular response to DNA damage stimulus mitotic G2 DNA damage checkpoint biological_process response to ionizing radiation Mre11 complex positive regulation of protein kinase activity protein localization to chromatin positive regulation of double-strand break repair via homologous recombination regulation of double-strand break repair via nonhomologous end joining uc007irv.1 uc007irv.2 uc007irv.3 uc007irv.4 
ENSMUST00000020649.14 Rad50 ENSMUST00000020649.14 RAD50 double strand break repair protein (from RefSeq NM_009012.2) ENSMUST00000020649.1 ENSMUST00000020649.10 ENSMUST00000020649.11 ENSMUST00000020649.12 ENSMUST00000020649.13 ENSMUST00000020649.2 ENSMUST00000020649.3 ENSMUST00000020649.4 ENSMUST00000020649.5 ENSMUST00000020649.6 ENSMUST00000020649.7 ENSMUST00000020649.8 ENSMUST00000020649.9 NM_009012 Q5SV02 Q5SV02_MOUSE Rad50 uc007iwt.1 uc007iwt.2 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Chromosome, telomere Belongs to the SMC family. RAD50 subfamily. telomere maintenance nucleus DNA repair ATPase activity Mre11 complex metal ion binding uc007iwt.1 uc007iwt.2 
ENSMUST00000020650.2 Il13 ENSMUST00000020650.2 interleukin 13 (from RefSeq NM_008355.3) ENSMUST00000020650.1 IL13_MOUSE Il-13 NM_008355 P20109 uc007iwr.1 uc007iwr.2 uc007iwr.3 uc007iwr.4 Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:15361238). Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (PubMed:34789557). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils. Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed:8871614, PubMed:34795444). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed:29305434). Interacts with IL13RA2. P20109; O88786: Il13ra2; NbExp=4; IntAct=EBI-20559598, EBI-20260800; Secreted. Deletion mice have increased eosinophilic inflammation and splenomegaly (PubMed:29305434). In addition, mice show exacerbated effects of IL33 administration, including increased immune cell infiltration in the peritoneum with expanded eosinophil and ILC2 populations, and reduced circulating and peritoneal sST2 (PubMed:34789557). Belongs to the IL-4/IL-13 family. microglial cell activation positive regulation of immunoglobulin production cytokine activity cytokine receptor binding interleukin-13 receptor binding protein binding extracellular region extracellular space cytoplasm inflammatory response immune response signal transduction external side of plasma membrane regulation of proton transport positive regulation of gene expression positive regulation of B cell proliferation positive regulation of connective tissue growth factor production negative regulation of NAD(P)H oxidase activity response to nicotine positive regulation of tyrosine phosphorylation of STAT protein positive regulation of macrophage activation positive regulation of ion transport positive regulation of mast cell degranulation positive regulation of smooth muscle cell proliferation positive regulation of protein secretion positive regulation of release of sequestered calcium ion into cytosol cellular response to cytokine stimulus negative regulation of transforming growth factor beta production negative regulation of neuron death negative regulation of complement-dependent cytotoxicity positive regulation of pancreatic stellate cell proliferation negative regulation of endothelial cell apoptotic process uc007iwr.1 uc007iwr.2 uc007iwr.3 uc007iwr.4 
ENSMUST00000020653.6 Sar1b ENSMUST00000020653.6 secretion associated Ras related GTPase 1B (from RefSeq NM_025535.2) ENSMUST00000020653.1 ENSMUST00000020653.2 ENSMUST00000020653.3 ENSMUST00000020653.4 ENSMUST00000020653.5 NM_025535 Q3UBL6 Q9CQC9 SAR1B_MOUSE Sar1b Sara1b Sara2 uc007iup.1 uc007iup.2 uc007iup.3 uc007iup.4 GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity). Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (By similarity). Homodimer (By similarity). Binds PREB (PubMed:11422940). Part of the COPII coat complex. Binds to the cytoplasmic tails of target proteins in the endoplasmic reticulum (By similarity). Interacts with SURF4 (By similarity). Endoplasmic reticulum membrane ; Peripheral membrane protein Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein Note=Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region. Embryonic lethality during late-gestation (PubMed:33964306). Mice display gastrointestinal abnormalities associated with chylomicron retention disease: they show lower plasma levels of triglycerides, total cholesterol, and HDL-cholesterol, along with reduced chylomicron secretion following gastric lipid gavage (PubMed:33964306). Conditional deletion in the liver depletes plasma lipids (PubMed:33186557). Belongs to the small GTPase superfamily. SAR1 family. nucleotide binding regulation of COPII vesicle coating GTPase activity protein binding GTP binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus intracellular protein transport ER to Golgi vesicle-mediated transport protein transport membrane vesicle organization vesicle-mediated transport COPII vesicle coat Golgi cisterna membrane metal ion binding membrane organization positive regulation of protein exit from endoplasmic reticulum endoplasmic reticulum exit site uc007iup.1 uc007iup.2 uc007iup.3 uc007iup.4 
ENSMUST00000020655.14 Jade2 ENSMUST00000020655.14 jade family PHD finger 2, transcript variant 2 (from RefSeq NM_199299.5) ENSMUST00000020655.1 ENSMUST00000020655.10 ENSMUST00000020655.11 ENSMUST00000020655.12 ENSMUST00000020655.13 ENSMUST00000020655.2 ENSMUST00000020655.3 ENSMUST00000020655.4 ENSMUST00000020655.5 ENSMUST00000020655.6 ENSMUST00000020655.7 ENSMUST00000020655.8 ENSMUST00000020655.9 JADE2_MOUSE Kiaa0239 NM_199299 Phf15 Q3UHD5 Q6IE83 Q6ZQF7 uc007iuq.1 uc007iuq.2 uc007iuq.3 Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (By similarity). Acts as a E3 ubiquitin- protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself (PubMed:25018020). Positive regulator of neurogenesis (PubMed:25018020). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3 (By similarity). Interacts (via C-terminus) with KDM1A (via AOD/Tower domain) (PubMed:25018020). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZQF7-1; Sequence=Displayed; Name=2; IsoId=Q6ZQF7-2; Sequence=VSP_021052, VSP_021053; The first PHD domain is essential for its E3 ubiquitin ligase activity. Strongly decreased level of KDM1A polyubiquitination resulting in increased level of KDM1A protein. Decelerated emergence of neural progenitors and mature neurons. Embryonic stem cells grow in aggregates with smoother-edged, rounder- shaped cell clones and fail to organize in rosettes with surrounding cells exhibiting neuronal morphology with extensive arborization. Decreased expression of neural markers. Belongs to the JADE family. Sequence=BAC97907.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; histone acetyltransferase complex protein polyubiquitination protein binding nucleoplasm protein ubiquitination transferase activity histone H3 acetylation histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K12 acetylation metal ion binding regulation of neurogenesis positive regulation of neurogenesis protein autoubiquitination SMAD protein signal transduction ubiquitin protein ligase activity neuron projection extension histone H4-K16 acetylation uc007iuq.1 uc007iuq.2 uc007iuq.3 
ENSMUST00000020657.13 Ube2b ENSMUST00000020657.13 ubiquitin-conjugating enzyme E2B, transcript variant 2 (from RefSeq NM_009458.5) ENSMUST00000020657.1 ENSMUST00000020657.10 ENSMUST00000020657.11 ENSMUST00000020657.12 ENSMUST00000020657.2 ENSMUST00000020657.3 ENSMUST00000020657.4 ENSMUST00000020657.5 ENSMUST00000020657.6 ENSMUST00000020657.7 ENSMUST00000020657.8 ENSMUST00000020657.9 NM_009458 P23567 P63147 Q3UGS2 Q9D0J6 Rad6b UBE2B_MOUSE Ube2b uc007iut.1 uc007iut.2 uc007iut.3 uc007iut.4 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys- 120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA- associated PCNA on 'Lys-164'. May be involved in neurite outgrowth. May play a role in DNA repair (By similarity). Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence= Protein modification; protein ubiquitination. Interacts with RAD18, UBR2 and WAC. Cell membrane Nucleus Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei. Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding protein polyubiquitination chromatin nuclear chromatin in utero embryonic development XY body ubiquitin-protein transferase activity protein binding ATP binding nucleus replication fork cytoplasm plasma membrane DNA repair postreplication repair maintenance of chromatin silencing ubiquitin-dependent protein catabolic process protein monoubiquitination cellular response to DNA damage stimulus spermatogenesis sperm axoneme assembly response to UV positive regulation of reciprocal meiotic recombination membrane protein ubiquitination transferase activity regulation of histone modification ubiquitin protein ligase binding negative regulation of histone phosphorylation HULC complex histone H2A ubiquitination response to drug negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of cAMP-mediated signaling meiotic telomere clustering protein stabilization chiasma assembly protein autoubiquitination ubiquitin conjugating enzyme activity histone lysine demethylation synaptonemal complex organization protein K63-linked ubiquitination protein K48-linked ubiquitination protein K11-linked ubiquitination positive regulation of canonical Wnt signaling pathway uc007iut.1 uc007iut.2 uc007iut.3 uc007iut.4 
ENSMUST00000020662.15 Kremen1 ENSMUST00000020662.15 kringle containing transmembrane protein 1 (from RefSeq NM_032396.3) ENSMUST00000020662.1 ENSMUST00000020662.10 ENSMUST00000020662.11 ENSMUST00000020662.12 ENSMUST00000020662.13 ENSMUST00000020662.14 ENSMUST00000020662.2 ENSMUST00000020662.3 ENSMUST00000020662.4 ENSMUST00000020662.5 ENSMUST00000020662.6 ENSMUST00000020662.7 ENSMUST00000020662.8 ENSMUST00000020662.9 KREM1_MOUSE Kremen NM_032396 Q640Q6 Q99N43 uc007hwh.1 uc007hwh.2 uc007hwh.3 uc007hwh.4 Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670). In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane (By similarity). Can trigger apoptosis in a Wnt- independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1 (PubMed:26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822). Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification (PubMed:27550540). Forms a ternary complex with DKK1 and LRP6 (PubMed:12050670). Interacts with LRP6 in a DKK1-dependent manner. Interacts with DKK1 and RSPO1 (via FU repeats) (By similarity). Cell membrane ; Single-pass type I membrane protein In the adult, widely expressed with high levels in heart, lung, kidney, skeletal muscle and testis. Expressed in the developing cochlea. Expressed first in the prosensory domain and the expression is restricted to supporting cells as development proceeds (at protein level). In the embryo, expression is first detected on day 9 and increases up to day 18. Lower levels are found in adult. At 9.5 dpc, expression is localized to the apical ectodermal ridge (AER) of the developing fore- and hindlimb buds, the telencephalon and the first brachial arch. At 10.5 dpc, expression is also observed in the myotome and in sensory tissues such as the nasal pit and optic vesicle. Expressed in the developing brain and developing limb buds. Animals with a double knockout of KREM1 and KREM2 exhibit enhanced Wnt signaling accompanied by ectopic postaxial forelimb digits and expanded apical ectodermal ridges. They also exhibit increased bone volume and bone formation rates. Triple knockout mice KREM1/KREM2/DKK1 exhibit enhanced growth of ectopic digits. molecular_function plasma membrane apoptotic process membrane integral component of membrane Wnt signaling pathway negative regulation of ossification neuronal cell body negative regulation of axon regeneration limb development negative regulation of canonical Wnt signaling pathway uc007hwh.1 uc007hwh.2 uc007hwh.3 uc007hwh.4 
ENSMUST00000020668.15 Havcr2 ENSMUST00000020668.15 hepatitis A virus cellular receptor 2 (from RefSeq NM_134250.2) ENSMUST00000020668.1 ENSMUST00000020668.10 ENSMUST00000020668.11 ENSMUST00000020668.12 ENSMUST00000020668.13 ENSMUST00000020668.14 ENSMUST00000020668.2 ENSMUST00000020668.3 ENSMUST00000020668.4 ENSMUST00000020668.5 ENSMUST00000020668.6 ENSMUST00000020668.7 ENSMUST00000020668.8 ENSMUST00000020668.9 HAVR2_MOUSE NM_134250 Q8VIM0 Tim3 Timd3 uc011xtp.1 uc011xtp.2 uc011xtp.3 uc011xtp.4 Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:18006747). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556006, PubMed:18006747). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits (By similarity). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (PubMed:21807895). Expressed on Treg cells can inhibit Th17 cell responses (By similarity). Receptor for LGALS9. Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6 (PubMed:22863785). Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis- infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (PubMed:20937702). However, the function as receptor for LGALS9 has been challenged (By similarity). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (PubMed:24567532). Receptor for phosphatidylserine (PtSer); PtSer- binding is calcium-dependent (PubMed:20083673). May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells (PubMed:19224762). Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells (PubMed:20083673). Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha (PubMed:18006747). In tumor- imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid- sensing and trafficking of nucleid acids to endosomes (PubMed:22842346). Can enhance mast cell production of Th2 cytokines Il-4, IL-6 and IL-13 (PubMed:17620455). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9. In contrast, shown to suppress NK cell-mediated cytotoxicity (By similarity). Negatively regulates NK cell function in LPS-induced endotoxic shock (PubMed:25337993). Interacts with HMGB1; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response (PubMed:22842346). Interacts with BAG6 (PubMed:22863785). Interacts (phosphorylated) with PIK3R1 and PIK3R2. Interacts (not dependent on its phosphorylation status) with FYN (PubMed:21807895). Interacts (in basal state T-cells) with VAV1; AKT1/2, LCP2, ZAP70, SYK, PIK3R1, FYN, SH3BP2 and SH2D2A. Interacts (in activated T-cells) with LCK and PLCG (By similarity). Interacts with ILF3; this interaction promotes ILF3 ubiquitination and degradation (By similarity). Q8VIM0; P63158: Hmgb1; NbExp=4; IntAct=EBI-6665112, EBI-6665811; Q8VIM0; O08573-2: Lgals9; NbExp=4; IntAct=EBI-6665112, EBI-11316797; [Isoform 1]: Membrane ; Single-pass type I membrane protein Cell junction Note=Localizes to the immunological synapse between CD8+ T-cells and target cells. [Isoform 2]: Secreted Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Tim-3L, flTim-3; IsoId=Q8VIM0-1; Sequence=Displayed; Name=2; Synonyms=sTim-3; IsoId=Q8VIM0-2; Sequence=VSP_058116; Expressed in T-helper type 1 lymphocytes. Not expressed by naive T-cells but up-regulated as they differentiate into T-helper-1 cells. Also expressed by differentiated type 1 CD8+ cytotoxic T-cells. Expressed on peritoneal exudate macrophages, monocytes, and splenic dendritic cells (DCs). Expression on natural killer (NK) cells is inversely associated with IFN-gamma production during the initial 24 hours of LPS-induced endotoxic shock. Expressed on mast cells. The Ig-like V-type (immunoglobulin-like) domain mediates binding to PtSer involving a Ca(2+) ion. Phosphorylated on tyrosine residues; modestly increased after TCR/CD28 stimulation. Can be phosphorylated in the cytoplasmatic domain by FYN (PubMed:21807895). Phosphorylation at Tyr-256 is increased by stimulation with ligand LGALS9 (By similarity). N-glycosylated. Polymorphic differences between BALB/c and HBA alleles in the Ig-like V-type domain are the reason for distinct binding affinities for PtSer. The HBA2 allele binds PtSer approximately 50% less than BALB/c. Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma. In vivo administration of antibody to HAVCR2 enhances the clinical and pathological severity of experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease and increases the number and activation level of macrophages. Endogenous expression on dendritic cells is proposed to act as a negative regulator of chemotherapy-induced antitumor responses. Belongs to the immunoglobulin superfamily. TIM family. Experimental results based on the injection of HAVCR2/TIM-3 antibodies or use of HAVCR2/TIM-3-Fc fusion proteins can reflect changes in the activity of several cell types and pathways as HAVCR2/TIM-3 is expressed by multiple immune cell types. Name=Functional Glycomics Gateway - Glycan Binding; Note=TIMD-3; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_other_382"; immunological synapse positive regulation of cytokine production adaptive immune response macrophage activation involved in immune response immune system process natural killer cell tolerance induction regulation of tolerance induction dependent upon immune response negative regulation of T-helper 1 type immune response negative regulation of immune response to tumor cell negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target protein binding extracellular region early endosome plasma membrane regulation of transcription from RNA polymerase II promoter inflammatory response cell surface negative regulation of gene expression membrane integral component of membrane mediator complex cell junction negative regulation of myeloid dendritic cell activation negative regulation of NF-kappaB transcription factor activity negative regulation of type I interferon production negative regulation of interferon-alpha production negative regulation of interferon-gamma production negative regulation of interleukin-2 production negative regulation of interleukin-3 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of chemokine production positive regulation of interferon-gamma production positive regulation of interleukin-1 production positive regulation of interleukin-4 production negative regulation of natural killer cell activation toll-like receptor 3 signaling pathway toll-like receptor 7 signaling pathway toll-like receptor 9 signaling pathway positive regulation of T cell proliferation negative regulation of T cell proliferation positive regulation of macrophage activation innate immune response positive regulation of innate immune response negative regulation of innate immune response metal ion binding defense response to Gram-positive bacterium maternal process involved in female pregnancy positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide negative regulation of granulocyte colony-stimulating factor production negative regulation of defense response to bacterium positive regulation of defense response to bacterium positive regulation of NIK/NF-kappaB signaling positive regulation of tumor necrosis factor secretion negative regulation of immunological synapse formation negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell uc011xtp.1 uc011xtp.2 uc011xtp.3 uc011xtp.4 
ENSMUST00000020672.5 Fabp6 ENSMUST00000020672.5 fatty acid binding protein 6 (from RefSeq NM_008375.2) ENSMUST00000020672.1 ENSMUST00000020672.2 ENSMUST00000020672.3 ENSMUST00000020672.4 FABP6_MOUSE Illbp NM_008375 P51162 Q5SRT9 uc007imt.1 uc007imt.2 uc007imt.3 uc007imt.4 The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within the ileum, the distal 25-30% of the small intestine, and plays a role in enterohepatic circulation of bile acids and cholesterol homeostasis. In humans, it has been reported that polymorphisms in FABP6 confer a protective effect in obese individuals from developing type 2 diabetes. In mice deficiency of this gene affects bile acid metabolism in a gender-specific manner and was reported to be required for efficient apical to basolateral transport of conjugated bile acids. [provided by RefSeq, Jan 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CJ043022.1, BX633352.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849389 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (PubMed:23251388). Stimulates gastric acid and pepsinogen secretion (By similarity). Cytoplasm Membrane; Peripheral membrane protein ; Cytoplasmic side Expressed in ovary granulosa and luteal cells. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Can bind at least two ligands per molecule, however, the stoichiometry is debated. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. fatty acid binding cytoplasm cytosol lipid transport bile acid metabolic process lipid binding membrane uc007imt.1 uc007imt.2 uc007imt.3 uc007imt.4 
ENSMUST00000020679.3 Nipal4 ENSMUST00000020679.3 NIPA-like domain containing 4 (from RefSeq NM_172524.3) A4QPF8 ENSMUST00000020679.1 ENSMUST00000020679.2 Ichn NIPA4_MOUSE NM_172524 Nipa4 Q8BZF2 uc007ioa.1 uc007ioa.2 uc007ioa.3 Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Sr(2+) and Fe(2+) but to a much less extent than Mg(2+) (PubMed:18667602). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway (By similarity). Reaction=Mg(2+)(in) = Mg(2+)(out); Xref=Rhea:RHEA:29827, ChEBI:CHEBI:18420; Evidence=; Kinetic parameters: KM=0.36 mM for magnesium ions ; Cell membrane ; Multi-pass membrane protein Up-regulated by low magnesium ion levels. Belongs to the NIPA family. molecular_function ion transport magnesium ion transmembrane transporter activity magnesium ion transport membrane integral component of membrane magnesium ion transmembrane transport uc007ioa.1 uc007ioa.2 uc007ioa.3 
ENSMUST00000020681.10 Slu7 ENSMUST00000020681.10 SLU7 splicing factor homolog (S. cerevisiae), transcript variant 2 (from RefSeq NM_198936.1) D11Ertd730e ENSMUST00000020681.1 ENSMUST00000020681.2 ENSMUST00000020681.3 ENSMUST00000020681.4 ENSMUST00000020681.5 ENSMUST00000020681.6 ENSMUST00000020681.7 ENSMUST00000020681.8 ENSMUST00000020681.9 NM_198936 Q3KQQ3 Q5SRU1 Q63ZX3 Q6P923 Q8BHJ9 Q8BL59 Q8BXD5 Q8R5C1 Q91YV6 SLU7_MOUSE uc007imq.1 uc007imq.2 uc007imq.3 Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Component of pre-catalytic, catalytic and post-catalytic spliceosomes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I. Nucleus Nucleus speckle Cytoplasm Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway. Belongs to the SLU7 family. Sequence=AAH13810.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAI24831.1; Type=Erroneous gene model prediction; Evidence=; RNA splicing, via transesterification reactions alternative mRNA splicing, via spliceosome second spliceosomal transesterification activity mRNA 3'-splice site recognition mRNA splicing, via spliceosome nucleus nucleoplasm spliceosomal complex cytoplasm cytosol mRNA processing intracellular protein transport zinc ion binding RNA splicing nuclear speck small nuclear ribonucleoprotein complex pre-mRNA 3'-splice site binding cellular response to heat intracellular membrane-bounded organelle metal ion binding catalytic step 2 spliceosome uc007imq.1 uc007imq.2 uc007imq.3 
ENSMUST00000020683.10 Hus1 ENSMUST00000020683.10 HUS1 checkpoint clamp component, transcript variant 4 (from RefSeq NR_130178.1) ENSMUST00000020683.1 ENSMUST00000020683.2 ENSMUST00000020683.3 ENSMUST00000020683.4 ENSMUST00000020683.5 ENSMUST00000020683.6 ENSMUST00000020683.7 ENSMUST00000020683.8 ENSMUST00000020683.9 HUS1_MOUSE NR_130178 O70543 Q6P8H5 Q8BQY8 uc007hzq.1 uc007hzq.2 uc007hzq.3 This gene encodes a component of a cell cycle checkpoint complex that causes cell cycle arrest in response to bulky DNA lesions and DNA replication blockage. Together with the proteins Rad9 and Rad1, the encoded protein forms a heterotrimeric complex known as the 9-1-1 complex. Mice lacking the encoded protein develop spontaneous chromosomal abnormalities resulting in embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the RAD17-RFC complex. HUS1 interacts with POLB, HDAC1, FEN1, PCNA and RAD9B. HUS1 does not interact with RAD17. Interacts with DNAJC7. Nucleus Cytoplasm, cytosol Note=In discrete nuclear foci upon DNA damage. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BQY8-1; Sequence=Displayed; Name=2; IsoId=Q8BQY8-2; Sequence=VSP_017332; Name=3; IsoId=Q8BQY8-3; Sequence=VSP_017332, VSP_017333; Ubiquitous. Belongs to the HUS1 family. DNA damage checkpoint telomere maintenance double-strand break repair via homologous recombination regulation of protein phosphorylation nucleus nucleolus cytoplasm nucleotide-excision repair protein phosphorylation cellular response to DNA damage stimulus mitotic cell cycle checkpoint negative regulation of DNA replication response to UV embryo development ending in birth or egg hatching checkpoint clamp complex intra-S DNA damage checkpoint mitotic DNA replication checkpoint site of double-strand break meiotic DNA integrity checkpoint cellular response to ionizing radiation uc007hzq.1 uc007hzq.2 uc007hzq.3 
ENSMUST00000020687.15 Pttg1 ENSMUST00000020687.15 pituitary tumor-transforming gene 1, transcript variant 19 (from RefSeq NM_001425553.1) ENSMUST00000020687.1 ENSMUST00000020687.10 ENSMUST00000020687.11 ENSMUST00000020687.12 ENSMUST00000020687.13 ENSMUST00000020687.14 ENSMUST00000020687.2 ENSMUST00000020687.3 ENSMUST00000020687.4 ENSMUST00000020687.5 ENSMUST00000020687.6 ENSMUST00000020687.7 ENSMUST00000020687.8 ENSMUST00000020687.9 NM_001425553 O88887 PTTG1_MOUSE Pttg Q9CQJ7 Q9Z2E6 uc011xth.1 uc011xth.2 uc011xth.3 Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of p53/TP53. The negative regulation of p53/TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity). Interacts with RPS10 and DNAJA1. Interacts with the caspase- like ESPL1, and prevents its protease activity probably by covering its active site. Interacts with p53/TP53 and blocks its activity probably by blocking its binding to DNA. Interacts with the Ku 70 kDa subunit of ds-DNA kinase. Interacts with PTTG1IP (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQJ7-1; Sequence=Displayed; Name=2; IsoId=Q9CQJ7-2; Sequence=VSP_006998, VSP_006999; During the stages 11.5-13.5 dpc it is expressed in most tissues of the embryo. Within the telencephalon, it is exclusively expressed inside of the ventricular zone (VZ). The expression reaches its peak by 15.5 dpc and starts to decrease by 18.5 dpc, and is not detectable in the adult brains. Most of the cells expressing it were found in the lower part of the ventricular zone. The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway. The TEK-boxes are required for 'Lys-11'-linked ubiquitination and facilitate the transfer of the first ubiquitin and ubiquitin chain nucleation. TEK-boxes may direct a catalytically competent orientation of the UBE2C/UBCH10-ubiquitin thioester with the acceptor lysine residue (By similarity). Phosphorylated at Ser-162 by CDC2 during mitosis. Phosphorylated in vitro by ds-DNA kinase. Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. 'Lys-11'-linked ubiquitination is mediated by the E2 ligase UBE2C/UBCH10 (By similarity). Belongs to the securin family. RNA polymerase II transcription factor activity, sequence-specific DNA binding regulation of cell growth cysteine-type endopeptidase inhibitor activity nucleus cytoplasm cytosol DNA repair regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cellular response to DNA damage stimulus cell cycle chromosome segregation mitotic sister chromatid cohesion negative regulation of cell proliferation cellular process negative regulation of endopeptidase activity SH3 domain binding heat shock protein binding ribosome binding homologous chromosome segregation chromosome organization cell division negative regulation of mitotic sister chromatid separation uc011xth.1 uc011xth.2 uc011xth.3 
ENSMUST00000020692.7 Btg2 ENSMUST00000020692.7 BTG anti-proliferation factor 2 (from RefSeq NM_007570.2) Btg2 ENSMUST00000020692.1 ENSMUST00000020692.2 ENSMUST00000020692.3 ENSMUST00000020692.4 ENSMUST00000020692.5 ENSMUST00000020692.6 NM_007570 Q3TF68 Q3TF68_MOUSE uc007cre.1 uc007cre.2 uc007cre.3 Belongs to the BTG family. negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding cellular response to DNA damage stimulus negative regulation of cell proliferation response to mechanical stimulus response to organic substance response to organonitrogen compound response to organic cyclic compound negative regulation of translation neuron differentiation neuron projection development negative regulation of apoptotic process response to peptide hormone negative regulation of neuron apoptotic process response to electrical stimulus positive regulation of nuclear-transcribed mRNA poly(A) tail shortening uc007cre.1 uc007cre.2 uc007cre.3 
ENSMUST00000020699.4 Castor1 ENSMUST00000020699.4 cytosolic arginine sensor for mTORC1 subunit 1 (from RefSeq NM_028022.2) CAST1_MOUSE Castor1 ENSMUST00000020699.1 ENSMUST00000020699.2 ENSMUST00000020699.3 Gatsl3 NM_028022 Q29R56 Q9CWQ8 uc007hur.1 uc007hur.2 uc007hur.3 Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. Forms homodimers and heterodimers with CASTOR2 (By similarity). Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by arginine (By similarity). Interacts with TM4SF5; the interaction is positively regulated by leucine and is negatively regulated by arginine (By similarity). Cytoplasm, cytosol Based on x-ray crystallography data, the protein would be constituted of 4 tandem ACT domains instead of the 2 predicted from the sequence. Phosphorylation at Ser-14 by AKT1, promoting the interaction between CASTOR1 and RNF167. Ubiquitinated by RNF167 via 'Lys-29'-polyubiquitination, leading to its degradation, releasing the GATOR2 complex. Ubiquitination by RNF167 is promoted by phosphorylation at Ser-14 by AKT1. Belongs to the GATS family. cytoplasm cytosol arginine binding identical protein binding GATOR2 complex regulation of intracellular signal transduction regulation of TORC1 signaling cellular response to L-arginine negative regulation of TORC1 signaling uc007hur.1 uc007hur.2 uc007hur.3 
ENSMUST00000020702.11 Igfbp3 ENSMUST00000020702.11 insulin-like growth factor binding protein 3 (from RefSeq NM_008343.2) ENSMUST00000020702.1 ENSMUST00000020702.10 ENSMUST00000020702.2 ENSMUST00000020702.3 ENSMUST00000020702.4 ENSMUST00000020702.5 ENSMUST00000020702.6 ENSMUST00000020702.7 ENSMUST00000020702.8 ENSMUST00000020702.9 IBP3_MOUSE Igfbp-3 NM_008343 P47878 Q6PE62 uc007hzi.1 uc007hzi.2 uc007hzi.3 uc007hzi.4 uc007hzi.5 IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis. Interacts with XLKD1. Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with TMEM219 (By similarity). Secreted. Phosphorylated by FAM20C in the extracellular medium. No effect on baseline apoptosis in the testis but germ cell apoptosis is dramatically reduced following treatment with a gonadotropin-releasing hormone antagonist. regulation of cell growth osteoblast differentiation negative regulation of protein phosphorylation fibronectin binding insulin-like growth factor binding extracellular region extracellular space nucleus nuclear heterochromatin protein phosphorylation protein tyrosine phosphatase activator activity negative regulation of cell proliferation positive regulation of cardiac muscle cell apoptotic process regulation of glucose metabolic process negative regulation of smooth muscle cell migration growth factor binding platelet alpha granule insulin-like growth factor I binding insulin-like growth factor II binding regulation of growth insulin-like growth factor ternary complex insulin-like growth factor binary complex positive regulation of apoptotic process positive regulation of MAPK cascade regulation of insulin-like growth factor receptor signaling pathway positive regulation of insulin-like growth factor receptor signaling pathway regulation of phosphoprotein phosphatase activity type B pancreatic cell proliferation positive regulation of myoblast differentiation negative regulation of smooth muscle cell proliferation positive regulation of apoptotic DNA fragmentation negative regulation of testosterone secretion uc007hzi.1 uc007hzi.2 uc007hzi.3 uc007hzi.4 uc007hzi.5 
ENSMUST00000020704.8 Igfbp1 ENSMUST00000020704.8 insulin-like growth factor binding protein 1 (from RefSeq NM_008341.4) ENSMUST00000020704.1 ENSMUST00000020704.2 ENSMUST00000020704.3 ENSMUST00000020704.4 ENSMUST00000020704.5 ENSMUST00000020704.6 ENSMUST00000020704.7 IBP1_MOUSE Igfbp-1 NM_008341 P47876 Q5SVY8 Q61732 uc007hzh.1 uc007hzh.2 uc007hzh.3 uc007hzh.4 IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity). Binds equally well IGF1 and IGF2. Secreted. insulin-like growth factor binding extracellular region extracellular space Golgi apparatus aging insulin receptor signaling pathway growth factor binding positive regulation of cell growth insulin-like growth factor I binding insulin-like growth factor II binding tissue regeneration regulation of insulin-like growth factor receptor signaling pathway uc007hzh.1 uc007hzh.2 uc007hzh.3 uc007hzh.4 
ENSMUST00000020705.5 Pes1 ENSMUST00000020705.5 pescadillo ribosomal biogenesis factor 1 (from RefSeq NM_022889.3) ENSMUST00000020705.1 ENSMUST00000020705.2 ENSMUST00000020705.3 ENSMUST00000020705.4 NM_022889 PESC_MOUSE Pes Q542F0 Q9EQ61 uc007hua.1 uc007hua.2 Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:15225545). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome (By similarity). The PeBoW complex also associates with DDX27, PES1 interacts directly with DDX27 (By similarity). Interacts with IRS1 and UBTF (PubMed:15169904). May interact with MAP1B (PubMed:17308336). Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. Ubiquitous. Highest levels appear to be found in tissues that contain a population of proliferating cells, such as ovary and testis. Also appears to be highly expressed in kidney and liver. In the brain expression is restricted to neural progenitor cells and postmitotic neurons. Highly expressed in malignant astrocytes. In 2-cell and 4-cell stage interphase blastomeres expression is restricted to a sub-nuclear band that encircles one or more large vacuoles within the nucleus. These vacuoles may give rise to the mature nucleolus. Later in embryogenesis high levels are detected in developing liver. Is also widely and highly expressed throughout the developing brain and spinal cord at embryonic day 13. Induced in malignant astrocytes following the loss of p53. Induced in hepatocytes following partial hepatectomy. Sumoylated. Embryos die during preimplantation stages of development, with blastomeres failing to progress past morula stages. Within blastocysts the nucleoli fail to form correctly and the number of ribosomes appears dramatically reduced. Belongs to the pescadillo family. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) condensed chromosome protein binding nucleus nucleoplasm chromosome nucleolus cytosol rRNA processing nucleolus organization cell proliferation preribosome, large subunit precursor protein localization to organelle ribosome biogenesis ribosomal large subunit biogenesis ribonucleoprotein complex binding regulation of cell cycle PeBoW complex uc007hua.1 uc007hua.2 
ENSMUST00000020706.5 Adcy1 ENSMUST00000020706.5 adenylate cyclase 1 (from RefSeq NM_009622.2) ADCY1_MOUSE ENSMUST00000020706.1 ENSMUST00000020706.2 ENSMUST00000020706.3 ENSMUST00000020706.4 NM_009622 O88444 Q5SS89 uc007hzf.1 uc007hzf.2 uc007hzf.3 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (PubMed:9662407, PubMed:7816821). May be involved in regulatory processes in the central nervous system (PubMed:9662407). May play a role in memory and learning (PubMed:7816821). Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (PubMed:24048828). Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro). ; Activated by calcium/calmodulin (PubMed:9662407). Activated by forskolin. Activated by the G protein alpha subunit GNAS. Inhibited by the G protein beta and gamma subunit complex. Inhibited by the ATP analogs adenosine, 2'-deoxyadenosine and 2'-deoxy-3'-AMP. Interacts with CALM. Membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasm Membrane raft Note=Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia|. Expressed throughout inner ear development. Expression in the retina oscillates in a circadian manner. The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules. N-glycosylated. Mice appear grossly normal and healthy, but have decreased levels of calmodulin-sensitive adenylyl cyclase activity in the brain (PubMed:7816821). They show impaired spatial memory (PubMed:7816821). Mice show a significant reduction in daytime contrast sensitivity (PubMed:24048828). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding adenylate cyclase activity calmodulin binding ATP binding nucleus cytoplasm plasma membrane integral component of plasma membrane cAMP biosynthetic process adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity axonogenesis brain development long-term memory circadian rhythm calcium- and calmodulin-responsive adenylate cyclase activity cyclic nucleotide biosynthetic process response to lithium ion postsynaptic density membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity cAMP-mediated signaling positive regulation of CREB transcription factor activity intracellular signal transduction response to drug regulation of circadian rhythm membrane raft metal ion binding rhythmic process modulation of synaptic transmission cellular response to calcium ion glutamatergic synapse integral component of postsynaptic density membrane positive regulation of long-term synaptic potentiation cellular response to forskolin regulation of synaptic vesicle exocytosis uc007hzf.1 uc007hzf.2 uc007hzf.3 
ENSMUST00000020707.12 Gabra1 ENSMUST00000020707.12 gamma-aminobutyric acid type A receptor subunit alpha 1, transcript variant 1 (from RefSeq NM_010250.5) ENSMUST00000020707.1 ENSMUST00000020707.10 ENSMUST00000020707.11 ENSMUST00000020707.2 ENSMUST00000020707.3 ENSMUST00000020707.4 ENSMUST00000020707.5 ENSMUST00000020707.6 ENSMUST00000020707.7 ENSMUST00000020707.8 ENSMUST00000020707.9 Gabra1 NM_010250 Q544F7 Q544F7_MOUSE uc007imf.1 uc007imf.2 uc007imf.3 uc007imf.4 Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane Membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub- subfamily. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane integral component of plasma membrane ion transport chloride transport gamma-aminobutyric acid signaling pathway drug binding membrane integral component of membrane GABA receptor activity GABA-gated chloride ion channel activity ion transmembrane transport synaptic transmission, GABAergic cellular response to histamine GABA-ergic synapse integral component of postsynaptic specialization membrane chloride transmembrane transport GABA receptor complex GABA-A receptor complex inhibitory synapse assembly uc007imf.1 uc007imf.2 uc007imf.3 uc007imf.4 
ENSMUST00000020712.5 4921536K21Rik ENSMUST00000020712.5 RIKEN cDNA 4921536K21 gene (from RefSeq NM_026150.3) CE052_MOUSE ENSMUST00000020712.1 ENSMUST00000020712.2 ENSMUST00000020712.3 ENSMUST00000020712.4 NM_026150 Q3TSB3 Q9CR34 uc007hts.1 uc007hts.2 uc007hts.3 uc007hts.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CR34-1; Sequence=Displayed; Name=2; IsoId=Q9CR34-2; Sequence=VSP_034220; Sequence=BAE36762.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc007hts.1 uc007hts.2 uc007hts.3 uc007hts.4 
ENSMUST00000020717.12 Arf5 ENSMUST00000020717.12 ADP-ribosylation factor 5 (from RefSeq NM_007480.2) A2RTC5 ARF5_MOUSE ENSMUST00000020717.1 ENSMUST00000020717.10 ENSMUST00000020717.11 ENSMUST00000020717.2 ENSMUST00000020717.3 ENSMUST00000020717.4 ENSMUST00000020717.5 ENSMUST00000020717.6 ENSMUST00000020717.7 ENSMUST00000020717.8 ENSMUST00000020717.9 NM_007480 P26437 P84084 uc009bcq.1 uc009bcq.2 uc009bcq.3 GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Interacts (when activated) with GGA1, GGA2 and GGA3; the interaction is required for proper subcellular location of GGA1, GGA2 and GGA3 (PubMed:11950392). Binds ASAP2 (By similarity). Interacts with NCS1/FREQ at the Golgi complex. Interacts with RAB11FIP3 and RAB11FIP4 (By similarity). P84084; Q8BYR5: Cadps2; NbExp=5; IntAct=EBI-7569461, EBI-7569313; Golgi apparatus. Cytoplasm, perinuclear region Membrane ; Lipid-anchor Golgi apparatus, trans-Golgi network membrane ; Lipid-anchor Ubiquitous. Belongs to the small GTPase superfamily. Arf family. nucleotide binding protein binding GTP binding cytoplasm Golgi apparatus plasma membrane intracellular protein transport retrograde vesicle-mediated transport, Golgi to ER protein transport membrane vesicle-mediated transport perinuclear region of cytoplasm uc009bcq.1 uc009bcq.2 uc009bcq.3 
ENSMUST00000020719.7 2310033P09Rik ENSMUST00000020719.7 RIKEN cDNA 2310033P09 gene (from RefSeq NM_024210.2) ENSMUST00000020719.1 ENSMUST00000020719.2 ENSMUST00000020719.3 ENSMUST00000020719.4 ENSMUST00000020719.5 ENSMUST00000020719.6 MMTA2_MOUSE Mmtag2 NM_024210 Q99LX5 Q9CSK6 uc007jdl.1 uc007jdl.2 uc007jdl.3 uc007jdl.4 cellular_component biological_process uc007jdl.1 uc007jdl.2 uc007jdl.3 uc007jdl.4 
ENSMUST00000020741.12 Drg1 ENSMUST00000020741.12 developmentally regulated GTP binding protein 1 (from RefSeq NM_007879.2) Drg1 ENSMUST00000020741.1 ENSMUST00000020741.10 ENSMUST00000020741.11 ENSMUST00000020741.2 ENSMUST00000020741.3 ENSMUST00000020741.4 ENSMUST00000020741.5 ENSMUST00000020741.6 ENSMUST00000020741.7 ENSMUST00000020741.8 ENSMUST00000020741.9 NM_007879 Q5NBZ3 Q5NBZ3_MOUSE uc007hsh.1 uc007hsh.2 uc007hsh.3 GTPase activity GTP binding nucleus cytoplasm cytosol polysome microtubule binding nuclear body potassium ion binding positive regulation of microtubule polymerization identical protein binding regulation of mitotic spindle assembly uc007hsh.1 uc007hsh.2 uc007hsh.3 
ENSMUST00000020749.13 Mtif2 ENSMUST00000020749.13 mitochondrial translational initiation factor 2, transcript variant 3 (from RefSeq NM_001282119.1) ENSMUST00000020749.1 ENSMUST00000020749.10 ENSMUST00000020749.11 ENSMUST00000020749.12 ENSMUST00000020749.2 ENSMUST00000020749.3 ENSMUST00000020749.4 ENSMUST00000020749.5 ENSMUST00000020749.6 ENSMUST00000020749.7 ENSMUST00000020749.8 ENSMUST00000020749.9 IF2M_MOUSE NM_001282119 Q5M6W6 Q91YJ5 uc287xdu.1 uc287xdu.2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity). Monomer. Mitochondrion Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. nucleotide binding translation initiation factor activity GTPase activity GTP binding nucleoplasm mitochondrion translation translational initiation translation factor activity, RNA binding ribosome disassembly ribosomal small subunit binding mitochondrial translational initiation uc287xdu.1 uc287xdu.2 
ENSMUST00000020754.10 Cfap36 ENSMUST00000020754.10 cilia and flagella associated protein 36 (from RefSeq NM_025740.3) CFA36_MOUSE Ccdc104 Cfap36 ENSMUST00000020754.1 ENSMUST00000020754.2 ENSMUST00000020754.3 ENSMUST00000020754.4 ENSMUST00000020754.5 ENSMUST00000020754.6 ENSMUST00000020754.7 ENSMUST00000020754.8 ENSMUST00000020754.9 NM_025740 Q8C6E0 Q9CWQ4 uc007igu.1 uc007igu.2 uc007igu.3 May act as an effector for ARL3. Interacts with ARL3. Q8C6E0; Q9WUL7: Arl3; NbExp=5; IntAct=EBI-16180842, EBI-6860857; Nucleus Cytoplasm Cell projection, cilium, flagellum Belongs to the CFAP36 family. protein binding nucleus cytoplasm cilium biological_process motile cilium ciliary transition zone cell projection protein N-terminus binding ciliary base uc007igu.1 uc007igu.2 uc007igu.3 
ENSMUST00000020755.12 Ppp4r3b ENSMUST00000020755.12 protein phosphatase 4 regulatory subunit 3B, transcript variant 7 (from RefSeq NR_156485.1) ENSMUST00000020755.1 ENSMUST00000020755.10 ENSMUST00000020755.11 ENSMUST00000020755.2 ENSMUST00000020755.3 ENSMUST00000020755.4 ENSMUST00000020755.5 ENSMUST00000020755.6 ENSMUST00000020755.7 ENSMUST00000020755.8 ENSMUST00000020755.9 Kiaa1387 NR_156485 P4R3B_MOUSE Pp4r3b Ppp4r3b Q3V0E4 Q5M6V9 Q5RJC0 Q5RJC1 Q6ZPS5 Q8BTK2 Q8BY94 Q8BYY0 Q922R5 Smek2 uc007igs.1 uc007igs.2 uc007igs.3 uc007igs.4 Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers (By similarity). Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3B. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and (with higher levels) the nucleus. During metaphase located in pericentriolar regions. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q922R5-1; Sequence=Displayed; Name=2; IsoId=Q922R5-2; Sequence=VSP_021264, VSP_021265; Belongs to the SMEK family. Sequence=BAC98154.1; Type=Erroneous initiation; Evidence=; protein binding nucleus nucleoplasm cytoplasm centrosome microtubule organizing center cytoskeleton protein dephosphorylation nuclear speck regulation of lipid metabolic process protein phosphatase 4 complex positive regulation of gluconeogenesis uc007igs.1 uc007igs.2 uc007igs.3 uc007igs.4 
ENSMUST00000020756.9 Pnpt1 ENSMUST00000020756.9 polyribonucleotide nucleotidyltransferase 1, transcript variant 2 (from RefSeq NR_157297.1) ENSMUST00000020756.1 ENSMUST00000020756.2 ENSMUST00000020756.3 ENSMUST00000020756.4 ENSMUST00000020756.5 ENSMUST00000020756.6 ENSMUST00000020756.7 ENSMUST00000020756.8 NR_157297 PNPT1_MOUSE Pnpase Q3UEP9 Q810U7 Q812B3 Q8K1R3 Q8R2U3 Q9DC52 uc007igp.1 uc007igp.2 uc007igp.3 RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (By similarity). Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA. Reaction=phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n); Xref=Rhea:RHEA:22096, Rhea:RHEA-COMP:14527, Rhea:RHEA- COMP:17342, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:140395; EC=2.7.7.8; Homotrimer; in free form. Homooligomer. Component of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer containing 2 copies of SUPV3L1 and 3 copies of PNPT1. As part of the mitochondrial degradosome complex, interacts with GRSF1 in an RNA- dependent manner; the interaction enhances the activity of the complex. Interacts with TCL1A; the interaction has no effect on PNPT1 exonuclease activity. Cytoplasm Mitochondrion matrix Mitochondrion intermembrane space ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K1R3-1; Sequence=Displayed; Name=2; IsoId=Q8K1R3-2; Sequence=VSP_013639, VSP_013640; Mice show alteration in the mechanisms of polycistronic mtRNAs processing in mitochondria, resulting in fewer mature mtRNAs and a reduction in electron transport chain (ETC) components formation. Belongs to the polyribonucleotide nucleotidyltransferase family. Sequence=AAO33354.1; Type=Frameshift; Evidence=; 3'-5'-exoribonuclease activity mitochondrial RNA catabolic process mitochondrial mRNA catabolic process positive regulation of mitochondrial RNA catabolic process mitochondrial RNA processing mitochondrial RNA 5'-end processing mitochondrial RNA 3'-end processing nucleic acid binding RNA binding nuclease activity exonuclease activity polyribonucleotide nucleotidyltransferase activity nucleus cytoplasm mitochondrion mitochondrial intermembrane space endoplasmic reticulum membrane cytosol RNA processing mRNA processing RNA catabolic process mRNA catabolic process poly(U) RNA binding membrane transferase activity nucleotidyltransferase activity hydrolase activity poly(G) binding cellular response to oxidative stress miRNA binding cellular response to interferon-beta RNA import into mitochondrion rRNA import into mitochondrion polysomal ribosome regulation of cellular respiration RNA polyadenylation mitochondrial degradosome negative regulation of growth protein homooligomerization response to cAMP response to growth hormone positive regulation of mRNA catabolic process protein homotrimerization mitochondrion morphogenesis nuclear polyadenylation-dependent mRNA catabolic process mitotic cell cycle arrest nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic mitochondrial mRNA polyadenylation liver regeneration positive regulation of miRNA catabolic process regulation of cellular senescence uc007igp.1 uc007igp.2 uc007igp.3 
ENSMUST00000020759.12 Efemp1 ENSMUST00000020759.12 epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (from RefSeq NM_146015.2) ENSMUST00000020759.1 ENSMUST00000020759.10 ENSMUST00000020759.11 ENSMUST00000020759.2 ENSMUST00000020759.3 ENSMUST00000020759.4 ENSMUST00000020759.5 ENSMUST00000020759.6 ENSMUST00000020759.7 ENSMUST00000020759.8 ENSMUST00000020759.9 FBLN3_MOUSE Fbln3 NM_146015 Q6Y3N6 Q8BPB5 uc007ign.1 uc007ign.2 uc007ign.3 uc007ign.4 Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth (By similarity). Interacts with ECM1. Interacts with TIMP3. Secreted, extracellular space Secreted, extracellular space, extracellular matrix Note=Localizes to the lamina propria underneath the olfactory epithelium. Mice are viable and have no overt phenotype at birth. However, they exhibit reduced reproductivity and an early onset of aging-associated phenotypes including reduced lifespan, decreased body mass, lordokyphosis, reduced hair growth and generalized fat, muscle and organ atrophy. They also display multiple hernias associated with a reduction of elastic fibers in facia, the thin layer of connective tissue maintaining and protecting structures throughout the body. However, there is no apparent macular degeneration. Belongs to the fibulin family. epidermal growth factor-activated receptor activity epidermal growth factor receptor binding extracellular matrix structural constituent calcium ion binding extracellular region basement membrane extracellular space cytoplasm regulation of transcription, DNA-templated epidermal growth factor receptor signaling pathway growth factor activity positive regulation of cell proliferation negative regulation of neuron projection development peptidyl-tyrosine phosphorylation positive regulation of cell projection organization negative regulation of chondrocyte differentiation camera-type eye development embryonic eye morphogenesis post-embryonic eye morphogenesis regulation of glial cell migration uc007ign.1 uc007ign.2 uc007ign.3 uc007ign.4 
ENSMUST00000020767.4 Polm ENSMUST00000020767.4 polymerase (DNA directed), mu (from RefSeq NM_017401.2) DPOLM_MOUSE ENSMUST00000020767.1 ENSMUST00000020767.2 ENSMUST00000020767.3 G5E840 NM_017401 Q9JIW4 Q9JJW9 polmu uc007hxf.1 uc007hxf.2 uc007hxf.3 uc007hxf.4 Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Nucleus DPOLM has a reduced ability to distinguish dNTP and rNTP as substrates, and elongates them on DNA primer strand with a similar efficiency. It is able to polymerize nucleotides on RNA primer strands (By similarity). Belongs to the DNA polymerase type-X family. DNA binding DNA-directed DNA polymerase activity nucleus DNA repair base-excision repair double-strand break repair via nonhomologous end joining DNA recombination cellular response to DNA damage stimulus somatic hypermutation of immunoglobulin genes transferase activity nucleotidyltransferase activity B cell differentiation DNA polymerase activity metal ion binding DNA biosynthetic process uc007hxf.1 uc007hxf.2 uc007hxf.3 uc007hxf.4 
ENSMUST00000020768.4 Pgam2 ENSMUST00000020768.4 phosphoglycerate mutase 2 (from RefSeq NM_018870.3) ENSMUST00000020768.1 ENSMUST00000020768.2 ENSMUST00000020768.3 NM_018870 Pgam2 Q5NCI4 Q5NCI4_MOUSE uc007hxe.1 uc007hxe.2 uc007hxe.3 uc007hxe.4 Reaction=(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; Xref=Rhea:RHEA:15901, ChEBI:CHEBI:58272, ChEBI:CHEBI:58289; EC=5.4.2.11; Evidence=; Reaction=(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3- bisphosphoglycerate + H(+); Xref=Rhea:RHEA:17765, ChEBI:CHEBI:15378, ChEBI:CHEBI:57604, ChEBI:CHEBI:58248; EC=5.4.2.4; Evidence= Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. catalytic activity bisphosphoglycerate mutase activity phosphoglycerate mutase activity nucleus cytosol gluconeogenesis glycolytic process striated muscle contraction spermatogenesis response to inorganic substance isomerase activity intramolecular transferase activity, phosphotransferases 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity response to mercury ion cofactor binding uc007hxe.1 uc007hxe.2 uc007hxe.3 uc007hxe.4 
ENSMUST00000020775.9 Dynll2 ENSMUST00000020775.9 dynein light chain LC8-type 2, transcript variant 1 (from RefSeq NM_026556.4) A7M7R8 DYL2_MOUSE Dlc2 ENSMUST00000020775.1 ENSMUST00000020775.2 ENSMUST00000020775.3 ENSMUST00000020775.4 ENSMUST00000020775.5 ENSMUST00000020775.6 ENSMUST00000020775.7 ENSMUST00000020775.8 NM_026556 Q3TFB4 Q9D0M5 uc007kva.1 uc007kva.2 uc007kva.3 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non- catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer (PubMed:11546872). Interacts with DYNC1I1 (PubMed:11148209). Interacts with BMF (PubMed:11546872). Component of the myosin V motor complex (PubMed:11546872). Interacts with BCAS1 (By similarity). Interacts with Basson/BSN (By similarity). Interacts with AMBRA1 (via TQT motifs); tethering AMBRA1 to the cytoskeleton (By similarity). Interacts with IQUB (PubMed:36417862). Cytoplasm, cytoskeleton Belongs to the dynein light chain family. motor activity protein binding cytoplasm centrosome cytoskeleton cytoplasmic dynein complex microtubule microtubule associated complex microtubule-based process postsynaptic density dynein complex myosin V complex protein homodimerization activity dynein intermediate chain binding protein heterodimerization activity dynein light intermediate chain binding scaffold protein binding postsynapse glutamatergic synapse positive regulation of ATP-dependent microtubule motor activity, plus-end-directed ATP-dependent microtubule motor activity, plus-end-directed uc007kva.1 uc007kva.2 uc007kva.3 
ENSMUST00000020776.5 Ccdc117 ENSMUST00000020776.5 coiled-coil domain containing 117 (from RefSeq NM_134033.2) CC117_MOUSE Ccdc117 ENSMUST00000020776.1 ENSMUST00000020776.2 ENSMUST00000020776.3 ENSMUST00000020776.4 NM_134033 Q6PB51 Q8K217 Q99LL1 uc007hwp.1 uc007hwp.2 uc007hwp.3 uc007hwp.4 uc007hwp.5 Facilitates DNA repair, cell cycle progression, and cell proliferation through its interaction with CIAO2B. Interacts with CIAO2B; the interaction is direct. Interacts with MMS19; the interaction is indirect. Cytoplasm, cytoskeleton, spindle Nucleus Note=Mitotic spindle. Firstly detected at 8.5 dpc in pharyngeal arch regions, particularly in the first arch, and in developing outflow tract (OFT) regions. Expression continued through 9.5 dpc in the cardiac outflow tract and atria, and in second heart field (SHF)- containing pharyngeal arch with additional expression in lower craniofacial regions. Also expressed in the developing outflow tract and SHF-associated pharyngeal mesoderm, with additional expression observed in pharyngeal endoderm, outflow tract endocardium and ventral neural tube populations. molecular_function cellular_component biological_process uc007hwp.1 uc007hwp.2 uc007hwp.3 uc007hwp.4 uc007hwp.5 
ENSMUST00000020779.11 Mpo ENSMUST00000020779.11 myeloperoxidase (from RefSeq NM_010824.2) ENSMUST00000020779.1 ENSMUST00000020779.10 ENSMUST00000020779.2 ENSMUST00000020779.3 ENSMUST00000020779.4 ENSMUST00000020779.5 ENSMUST00000020779.6 ENSMUST00000020779.7 ENSMUST00000020779.8 ENSMUST00000020779.9 NM_010824 P11247 PERM_MOUSE Q5NCP1 uc011ycc.1 uc011ycc.2 uc011ycc.3 Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:11593004). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low density lipoprotein particles and limits vascular damage (By similarity). Reaction=chloride + H(+) + H2O2 = H2O + hypochlorous acid; Xref=Rhea:RHEA:28218, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:17996, ChEBI:CHEBI:24757; EC=1.11.2.2; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per monomer. ; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer. ; Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain (By similarity). Lysosome. Belongs to the peroxidase family. XPO subfamily. response to yeast hypochlorous acid biosynthetic process respiratory burst involved in defense response peroxidase activity extracellular space nucleus cytoplasm mitochondrion lysosome defense response response to oxidative stress aging heparin binding response to mechanical stimulus oxidoreductase activity removal of superoxide radicals heme binding secretory granule response to food response to lipopolysaccharide low-density lipoprotein particle remodeling azurophil granule defense response to bacterium hydrogen peroxide catabolic process intracellular membrane-bounded organelle metal ion binding defense response to fungus oxidation-reduction process response to gold nanoparticle uc011ycc.1 uc011ycc.2 uc011ycc.3 
ENSMUST00000020794.6 Ska2 ENSMUST00000020794.6 spindle and kinetochore associated complex subunit 2 (from RefSeq NM_025377.3) B2KGY1 ENSMUST00000020794.1 ENSMUST00000020794.2 ENSMUST00000020794.3 ENSMUST00000020794.4 ENSMUST00000020794.5 Fam33a NM_025377 Q9CR46 SKA2_MOUSE uc007ktk.1 uc007ktk.2 uc007ktk.3 Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA1; the heterodimer interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts directly with SKA1. Binds directly to microtubules; but with a much lower affinity than SKA1 in vivo (By similarity). Cytoplasm, cytoskeleton, spindle Chromosome, centromere, kinetochore Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore- associated proteins. Belongs to the SKA2 family. mitotic cell cycle chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed chromosome outer kinetochore chromosome cytoplasm spindle cytoskeleton microtubule spindle microtubule cell cycle chromosome segregation microtubule binding regulation of microtubule polymerization or depolymerization cell division uc007ktk.1 uc007ktk.2 uc007ktk.3 
ENSMUST00000020801.14 Smg8 ENSMUST00000020801.14 SMG8 nonsense mediated mRNA decay factor (from RefSeq NM_024262.1) B2KGQ4 ENSMUST00000020801.1 ENSMUST00000020801.10 ENSMUST00000020801.11 ENSMUST00000020801.12 ENSMUST00000020801.13 ENSMUST00000020801.2 ENSMUST00000020801.3 ENSMUST00000020801.4 ENSMUST00000020801.5 ENSMUST00000020801.6 ENSMUST00000020801.7 ENSMUST00000020801.8 ENSMUST00000020801.9 NM_024262 Q8BS62 Q8BSP7 Q8VE18 Q9DBW6 SMG8_MOUSE uc007ktg.1 uc007ktg.2 uc007ktg.3 Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (By similarity). Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Forms heterodimers with SMG9; this assembly form may represent a SMG1C intermediate form (By similarity). Phosphorylated by SMG1. Belongs to the SMG8 family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay molecular_function cellular_component regulation of protein kinase activity uc007ktg.1 uc007ktg.2 uc007ktg.3 
ENSMUST00000020804.8 Gdpd1 ENSMUST00000020804.8 glycerophosphodiester phosphodiesterase domain containing 1 (from RefSeq NM_025638.2) ENSMUST00000020804.1 ENSMUST00000020804.2 ENSMUST00000020804.3 ENSMUST00000020804.4 ENSMUST00000020804.5 ENSMUST00000020804.6 ENSMUST00000020804.7 GDPD1_MOUSE Gde4 Gdpd1 NM_025638 Q9CRY7 Q9CT14 Q9D4X7 uc007kte.1 uc007kte.2 uc007kte.3 uc007kte.4 Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:25528375, PubMed:25596343, PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC) (PubMed:25528375, PubMed:25596343, PubMed:27637550). May be involved in bioactive N-acylethanolamine biosynthesis from both N-acyl- lysoplasmenylethanolamin (N-acyl-lysoPlsEt) and N-acyl- lysophosphatidylethanolamin (N-acyl-lysoPE) (PubMed:25596343, PubMed:27637550). In addition, hydrolyzes glycerophospho-N- acylethanolamine to N-acylethanolamine (PubMed:25596343, PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine (PubMed:25528375). Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:38975, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57518, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38976; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+); Xref=Rhea:RHEA:53172, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57518, ChEBI:CHEBI:57603, ChEBI:CHEBI:73004; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53173; Evidence=; Reaction=H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:45436, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597, ChEBI:CHEBI:71464, ChEBI:CHEBI:85226; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45437; Evidence=; Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)- sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine; Xref=Rhea:RHEA:45544, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74544, ChEBI:CHEBI:85223; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45545; Evidence=; Reaction=H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine; Xref=Rhea:RHEA:56460, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71466, ChEBI:CHEBI:74544, ChEBI:CHEBI:85222; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56461; Evidence=; Reaction=H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine; Xref=Rhea:RHEA:53168, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71464, ChEBI:CHEBI:74544, ChEBI:CHEBI:85217; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53169; Evidence=; Reaction=1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn- glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:39927, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30909, ChEBI:CHEBI:58014; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39928; Evidence=; Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O- hexadecyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:41143, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64496, ChEBI:CHEBI:77580; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41144; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z- octadecenoyl)-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:38915, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:74544; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38916; Evidence=; Reaction=H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine = 1- hexadecanoyl-sn-glycero-3-phosphate + H(+) + N- hexadecanoylethanolamine; Xref=Rhea:RHEA:45592, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57518, ChEBI:CHEBI:71464, ChEBI:CHEBI:85335; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45593; Evidence=; Reaction=1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z- eicosatetraenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn- glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)- ethanolamine; Xref=Rhea:RHEA:53192, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:137016, ChEBI:CHEBI:137017; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53193; Evidence=; Reaction=1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)- ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine; Xref=Rhea:RHEA:53188, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71466, ChEBI:CHEBI:137010, ChEBI:CHEBI:137017; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53189; Evidence=; Reaction=1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl- ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine; Xref=Rhea:RHEA:53184, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71464, ChEBI:CHEBI:137009, ChEBI:CHEBI:137017; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53185; Evidence=; Lysophospholipase D activity is increased by magnesium and manganese and inhibited by calcium in a concentration dependent manner (By similarity). Loss of lysophospholipase D activity by addition of EDTA (PubMed:25596343). Kinetic parameters: KM=1.0 mM for lysophosphatidylcholine (lyso-PC) ; KM=0.32 mM for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) ; Note=kcat is 0.032 sec(-1) with lysophosphatidylcholine as substrate. kcat is 0.077 sec(-1) with 1-O-alkyl-sn-glycero-3-phosphocholine as substrate. ; pH dependence: Optimum pH is 7.4. ; Cytoplasm Membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region Endoplasmic reticulum Note=Concentrated at the perinuclear region and the cell periphery. Widely expressed (PubMed:25528375, PubMed:25596343). Up-regulated in white adipose tissue of obese mice. Belongs to the glycerophosphoryl diester phosphodiesterase family. Sequence=BAB27650.1; Type=Frameshift; Evidence=; lysophospholipase activity cytoplasm endoplasmic reticulum membrane lipid metabolic process phospholipid metabolic process phosphoric diester hydrolase activity membrane integral component of membrane hydrolase activity glycerophospholipid catabolic process metal ion binding alkylglycerophosphoethanolamine phosphodiesterase activity perinuclear region of cytoplasm N-acylethanolamine metabolic process uc007kte.1 uc007kte.2 uc007kte.3 uc007kte.4 
ENSMUST00000020820.2 Mrpl22 ENSMUST00000020820.2 mitochondrial ribosomal protein L22, transcript variant 2 (from RefSeq NR_166467.1) ENSMUST00000020820.1 NR_166467 Q8BK04 Q8BU88 RM22_MOUSE uc007jap.1 uc007jap.2 uc007jap.3 uc007jap.4 uc007jap.5 uc007jap.6 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uL22 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation large ribosomal subunit ribosome assembly uc007jap.1 uc007jap.2 uc007jap.3 uc007jap.4 uc007jap.5 uc007jap.6 
ENSMUST00000020822.12 Cnot8 ENSMUST00000020822.12 CCR4-NOT transcription complex, subunit 8, transcript variant 1 (from RefSeq NM_026949.5) CNOT8_MOUSE ENSMUST00000020822.1 ENSMUST00000020822.10 ENSMUST00000020822.11 ENSMUST00000020822.2 ENSMUST00000020822.3 ENSMUST00000020822.4 ENSMUST00000020822.5 ENSMUST00000020822.6 ENSMUST00000020822.7 ENSMUST00000020822.8 ENSMUST00000020822.9 NM_026949 Q3U532 Q9D8X5 uc007jaj.1 uc007jaj.2 Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. In the complex interacts directly with CNOT1. Interacts with BTG1, BTG2 and TOB1 (By similarity). Interacts with BTG4 (PubMed:27065194). Q9D8X5; Q04211: Btg2; NbExp=3; IntAct=EBI-16204625, EBI-7847081; Cytoplasm Nucleus Expressed in embryonic stem (ES) cells. Belongs to the CAF1 family. 3'-5'-exoribonuclease activity P-body nucleic acid binding RNA binding nuclease activity exonuclease activity poly(A)-specific ribonuclease activity nucleus cytoplasm transcription, DNA-templated regulation of translation positive regulation of cell proliferation hydrolase activity negative regulation of translation CCR4-NOT complex CCR4-NOT core complex gene silencing by RNA exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay metal ion binding positive regulation of mRNA catabolic process nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic uc007jaj.1 uc007jaj.2 
ENSMUST00000020826.6 Sap30l ENSMUST00000020826.6 SAP30-like, transcript variant 1 (from RefSeq NM_001081168.2) ENSMUST00000020826.1 ENSMUST00000020826.2 ENSMUST00000020826.3 ENSMUST00000020826.4 ENSMUST00000020826.5 NM_001081168 Q504M9 Q5SQF8 Q9CUZ7 SP30L_MOUSE uc007jae.1 uc007jae.2 uc007jae.3 Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence- specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import. Interacts with components of the histone deacetylase complex SIN3A, HDAC1 and HDAC2. Binds histones and nucleosomes. Interacts with FEZ1. Nucleus, nucleolus The zinc-finger domain mediates direct interaction with DNA and phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate). In vitro oxydation causes reversible disulfide bond formation between Cys residues in the zinc-finger domain and reversible loss of zinc ion binding. Belongs to the SAP30 family. Sequence=AAH94930.1; Type=Erroneous initiation; Evidence=; histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter DNA binding histone deacetylase activity nucleus nucleolus regulation of transcription, DNA-templated zinc ion binding lipid binding phosphatidylinositol-5-phosphate binding histone deacetylation nucleosome binding phosphatidylinositol-3-phosphate binding histone binding non-sequence-specific DNA binding, bending metal ion binding phosphatidylinositol-4-phosphate binding uc007jae.1 uc007jae.2 uc007jae.3 
ENSMUST00000020827.7 Rnft1 ENSMUST00000020827.7 ring finger protein, transmembrane 1 (from RefSeq NM_029788.5) ENSMUST00000020827.1 ENSMUST00000020827.2 ENSMUST00000020827.3 ENSMUST00000020827.4 ENSMUST00000020827.5 ENSMUST00000020827.6 NM_029788 Q3U649 Q80X62 Q9DCN7 RNFT1_MOUSE uc007ksl.1 uc007ksl.2 uc007ksl.3 E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Early endosome membrane ; Multi-pass membrane protein Predominantly expressed in testis. Expression in testis already detected at postnatal day 1 (P1), progressively increases with adult levels reached at P20. endosome endoplasmic reticulum membrane integral component of membrane protein ubiquitination transferase activity early endosome membrane ubiquitin binding metal ion binding protein autoubiquitination ubiquitin protein ligase activity positive regulation of ERAD pathway uc007ksl.1 uc007ksl.2 uc007ksl.3 
ENSMUST00000020831.13 Fam114a2 ENSMUST00000020831.13 family with sequence similarity 114, member A2, transcript variant 2 (from RefSeq NM_026342.3) ENSMUST00000020831.1 ENSMUST00000020831.10 ENSMUST00000020831.11 ENSMUST00000020831.12 ENSMUST00000020831.2 ENSMUST00000020831.3 ENSMUST00000020831.4 ENSMUST00000020831.5 ENSMUST00000020831.6 ENSMUST00000020831.7 ENSMUST00000020831.8 ENSMUST00000020831.9 F1142_MOUSE NM_026342 Q3UE42 Q5QNR1 Q8VE88 Q9D310 uc007izv.1 uc007izv.2 uc007izv.3 uc007izv.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VE88-1; Sequence=Displayed; Name=2; IsoId=Q8VE88-2; Sequence=VSP_022796; Belongs to the FAM114 family. molecular_function cellular_component biological_process uc007izv.1 uc007izv.2 uc007izv.3 uc007izv.4 
ENSMUST00000020835.16 Ppm1d ENSMUST00000020835.16 protein phosphatase 1D magnesium-dependent, delta isoform (from RefSeq NM_016910.3) B1B0B0 ENSMUST00000020835.1 ENSMUST00000020835.10 ENSMUST00000020835.11 ENSMUST00000020835.12 ENSMUST00000020835.13 ENSMUST00000020835.14 ENSMUST00000020835.15 ENSMUST00000020835.2 ENSMUST00000020835.3 ENSMUST00000020835.4 ENSMUST00000020835.5 ENSMUST00000020835.6 ENSMUST00000020835.7 ENSMUST00000020835.8 ENSMUST00000020835.9 NM_016910 PPM1D_MOUSE Q9QZ67 Wip1 uc007krl.1 uc007krl.2 uc007krl.3 uc007krl.4 Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation (By similarity). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (PubMed:24135283). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit. ; Interacts with CHEK1 and CHEK2; dephosphorylates them. Interacts with MAPK14. Nucleus Cytoplasm, cytosol Ubiquitously expressed. By p53. Knockout mice show defective spermatogenesis. On histological sections, testes display an abnormal architecture and considerably narrower seminiferous tubules than those of wild-type mice, accompanied by changes in heterochromatin structure and globally altered gene expression in germ cells, and depletion of the most differentiated germ cell types. Belongs to the PP2C family. G2/M transition of mitotic cell cycle catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity nucleus cytoplasm cytosol DNA methylation chromatin silencing protein dephosphorylation cell cycle cellular response to starvation response to bacterium hydrolase activity DNA damage response, signal transduction by p53 class mediator peptidyl-threonine dephosphorylation cation binding negative regulation of gene expression, epigenetic metal ion binding mitogen-activated protein kinase binding uc007krl.1 uc007krl.2 uc007krl.3 uc007krl.4 
ENSMUST00000020846.8 Srebf1 ENSMUST00000020846.8 sterol regulatory element binding transcription factor 1, transcript variant 1 (from RefSeq NM_011480.4) ENSMUST00000020846.1 ENSMUST00000020846.2 ENSMUST00000020846.3 ENSMUST00000020846.4 ENSMUST00000020846.5 ENSMUST00000020846.6 ENSMUST00000020846.7 NM_011480 Q3U458 Q3UDJ3 Q5SRX5 Q8C733 Q99JK7 Q9WTN3 SRBP1_MOUSE Srebf1 Srebp1 uc007jfn.1 uc007jfn.2 uc007jfn.3 uc007jfn.4 This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. [provided by RefSeq, Nov 2017]. [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element- binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:11782483, PubMed:12855691, PubMed:19244231). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:11782483, PubMed:12855691, PubMed:16100574, PubMed:19244231). [Processed sterol regulatory element-binding protein 1]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:19244231, PubMed:17290224, PubMed:9329978, PubMed:9784493, PubMed:21459323). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') (By similarity). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:19244231, PubMed:17290224, PubMed:9329978, PubMed:9784493, PubMed:21459323). [Isoform SREBP-1A]: Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (PubMed:12855691, PubMed:21531336). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:8833906). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (PubMed:9062341, PubMed:12855691). Required for innate immune response in macrophages by regulating lipid metabolism (PubMed:21531336). [Isoform SREBP-1C]: Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (PubMed:12855691, PubMed:21531336). Primarily controls expression of lipogenic gene (PubMed:8833906, PubMed:9062341). Strongly activates global lipid synthesis in rapidly growing cells (PubMed:8833906, PubMed:9062341). Activation by cleavage is down-regulated upon activation of SIRT3-dependent PRKAA1/AMPK-alpha signaling cascade which leads to inhibition of ATP-consuming lipogenesis to restore cellular energy balance. [Sterol regulatory element-binding protein 1]: Forms a tight complex with SCAP, the SCAP-SREBP complex, in the endoplasmic reticulum membrane. [Processed sterol regulatory element-binding protein 1]: Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein (By similarity). Interacts with CEBPA, the interaction produces a transcriptional synergy (PubMed:17290224). Interacts with LMNA (PubMed:11929849). Q9WTN3; Q923E4: Sirt1; NbExp=2; IntAct=EBI-5273743, EBI-1802585; [Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane ; Multi- pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasmic vesicle, COPII-coated vesicle membrane ; Multi-pass membrane protein Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum (PubMed:21459323). Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed (PubMed:21459323). [Processed sterol regulatory element-binding protein 1]: Nucleus Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=SREBP-1A IsoId=Q9WTN3-1; Sequence=Displayed; Name=SREBP-1A-W42; IsoId=Q9WTN3-2; Sequence=VSP_002152; Name=SREBP-1C ; IsoId=Q9WTN3-3; Sequence=VSP_002151; Name=SREBP-1C-W42; IsoId=Q9WTN3-4; Sequence=VSP_002151, VSP_002152; [Isoform SREBP-1C]: Predominant isoform expressed in most tissues (PubMed:21531336). Predominates in liver, adrenal gland, brain and adipose tissue (PubMed:9062340). Also found in kidney, thymus, testis, muscle, jejunum, and ileum (PubMed:9062340). [Isoform SREBP-1A]: Expressed only in select tissues, such as intestinal epithelial, heart, macrophage and bone marrow dendritic cells (PubMed:9062340, PubMed:21531336). Also found in kidney, thymus, testis, muscle, jejunum, and ileum (PubMed:9062340). [Isoform SREBP-1C]: Expressed in a circadian manner in the liver with a peak at ZT16 (PubMed:19786558). Up-regulated by endocannabinoid anandamide/AEA. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. [Sterol regulatory element-binding protein 1]: Processed in the Golgi apparatus, releasing the protein from the membrane. At low cholesterol the SCAP-SREBP complex is recruited into COPII vesicles for export from the endoplasmic reticulum. In the Golgi, complex SREBPs are cleaved sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases (By similarity). The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain, releasing the transcription factor from the Golgi membrane (By similarity). Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. Phosphorylation at Ser-389 by SIK1 represses activity possibly by inhibiting DNA-binding. [Processed sterol regulatory element-binding protein 1]: Ubiquitinated; the nuclear form has a rapid turnover and is rapidly ubiquitinated and degraded by the proteasome in the nucleus. Mice show high embryonic lethality around day 11 dpc (PubMed:9329978). Surviving mice show a 2-3-fold increase in processed Srebpf2 protein in liver nuclei, 3-fold increase in cholesterol synthesis and 50% increase in cholesterol content of the liver (PubMed:9329978). [Isoform SREBP-1A]: Mice lacking isoform SREBP-1A are resistant to pro-inflammatory toxic shock (PubMed:21531336). Macrophages challenged with bacterial lipopolysaccharide fail to activate lipogenesis as well as hallmarks of inflammasome functions, activation of caspase-1 and secretion of IL1B (PubMed:21531336). [Isoform SREBP-1C]: Mice lacking isoform SREBP-1C show a lack of up-regulation of several lipogenic enzymes in response to high insulin or LXR activation. Belongs to the SREBP family. negative regulation of transcription from RNA polymerase II promoter Golgi membrane RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding regulation of heart rate by chemical signal DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus regulation of transcription, DNA-templated lipid metabolic process aging circadian rhythm steroid metabolic process cholesterol metabolic process insulin receptor signaling pathway lipid biosynthetic process cellular response to starvation response to glucose positive regulation of triglyceride biosynthetic process ER to Golgi transport vesicle membrane response to organic cyclic compound membrane integral component of membrane regulation of fatty acid metabolic process protein kinase binding lung development intracellular receptor signaling pathway positive regulation of histone deacetylation cytoplasmic vesicle regulation of protein stability response to food response to retinoic acid response to progesterone sterol response element binding cellular response to insulin stimulus macromolecular complex response to glucagon response to lipid response to drug mRNA transcription from RNA polymerase II promoter intracellular membrane-bounded organelle response to peptide hormone sequence-specific DNA binding transcription regulatory region DNA binding macromolecular complex binding fat cell differentiation positive regulation of cholesterol biosynthetic process positive regulation of fatty acid biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion protein dimerization activity regulation of insulin secretion response to cAMP response to fatty acid cellular response to fatty acid positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of mitophagy regulation of protein targeting to mitochondrion uc007jfn.1 uc007jfn.2 uc007jfn.3 uc007jfn.4 
ENSMUST00000020849.9 Tom1l1 ENSMUST00000020849.9 target of myb1-like 1 (chicken), transcript variant 1 (from RefSeq NM_001357543.1) B0QZV4 ENSMUST00000020849.1 ENSMUST00000020849.2 ENSMUST00000020849.3 ENSMUST00000020849.4 ENSMUST00000020849.5 ENSMUST00000020849.6 ENSMUST00000020849.7 ENSMUST00000020849.8 NM_001357543 Q5SRC7 Q5SRC9 Q923U0 Q99KE0 Q9D6Y5 Srcasm TM1L1_MOUSE uc007kxc.1 uc007kxc.2 uc007kxc.3 Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions. Interacts with LYN (By similarity). Interacts with the SH2 and SH3 domains of FYN when phosphorylated. Also interacts with GRB2 and PIK3R1 when phosphorylated. Golgi apparatus, Golgi stack. Endosome membrane Cytoplasm Membrane ; Peripheral membrane protein ; Cytoplasmic side Note=A small proportion is membrane-associated. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q923U0-1; Sequence=Displayed; Name=2; IsoId=Q923U0-2; Sequence=VSP_003996; Name=3; IsoId=Q923U0-3; Sequence=VSP_003997; Strongly expressed in brain and kidney, expressed at intermediate levels skin and heart, and weakly expressed in thymus. Not expressed in liver and spleen. Phosphorylated on tyrosines by LYN (By similarity). Phosphorylated on tyrosines by FYN. Belongs to the TOM1 family. protein binding cytoplasm endosome Golgi apparatus Golgi stack cytosol intracellular protein transport signal transduction transmembrane receptor protein tyrosine kinase signaling pathway endosome membrane protein transport membrane SH3 domain binding protein kinase binding clathrin binding protein kinase activator activity positive regulation of protein autophosphorylation activation of protein kinase activity negative regulation of mitotic nuclear division uc007kxc.1 uc007kxc.2 uc007kxc.3 
ENSMUST00000020851.15 Cox11 ENSMUST00000020851.15 cytochrome c oxidase assembly protein 11, copper chaperone (from RefSeq NM_199008.2) COX11_MOUSE ENSMUST00000020851.1 ENSMUST00000020851.10 ENSMUST00000020851.11 ENSMUST00000020851.12 ENSMUST00000020851.13 ENSMUST00000020851.14 ENSMUST00000020851.2 ENSMUST00000020851.3 ENSMUST00000020851.4 ENSMUST00000020851.5 ENSMUST00000020851.6 ENSMUST00000020851.7 ENSMUST00000020851.8 ENSMUST00000020851.9 NM_199008 Q3UNX9 Q6P8I6 uc007kwz.1 uc007kwz.2 uc007kwz.3 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. Interacts with CNNM4/ACDP4. Interacts with RANBP2. Mitochondrion inner membrane ; Single-pass membrane protein ; Intermembrane side Belongs to the COX11/CtaG family. copper ion binding protein binding mitochondrion mitochondrial inner membrane membrane integral component of membrane integral component of mitochondrial inner membrane macromolecular complex negative regulation of glucokinase activity metal ion homeostasis uc007kwz.1 uc007kwz.2 uc007kwz.3 
ENSMUST00000020856.6 Bzw2 ENSMUST00000020856.6 basic leucine zipper and W2 domains 2 (from RefSeq NM_025840.3) 5MP1_MOUSE 5mp1 ENSMUST00000020856.1 ENSMUST00000020856.2 ENSMUST00000020856.3 ENSMUST00000020856.4 ENSMUST00000020856.5 NM_025840 Q91VK1 Q9D0N4 uc007njp.1 uc007njp.2 uc007njp.3 Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (By similarity). Increases the accuracy of translation initiation by impeding EIF5- dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (By similarity). Interacts with EIF3E, EIF2S2 and EIF3C. Cytoplasm Belongs to the BZW family. cytoplasm multicellular organism development nervous system development cell differentiation uc007njp.1 uc007njp.2 uc007njp.3 
ENSMUST00000020864.9 Pctp ENSMUST00000020864.9 phosphatidylcholine transfer protein, transcript variant 1 (from RefSeq NM_008796.3) ENSMUST00000020864.1 ENSMUST00000020864.2 ENSMUST00000020864.3 ENSMUST00000020864.4 ENSMUST00000020864.5 ENSMUST00000020864.6 ENSMUST00000020864.7 ENSMUST00000020864.8 NM_008796 Pctp Q5SV41 Q5SV41_MOUSE uc007kwl.1 uc007kwl.2 uc007kwl.3 uc007kwl.4 lipid binding uc007kwl.1 uc007kwl.2 uc007kwl.3 uc007kwl.4 
ENSMUST00000020877.9 Polr1f ENSMUST00000020877.9 RNA polymerase I subunit F (from RefSeq NM_172253.2) ENSMUST00000020877.1 ENSMUST00000020877.2 ENSMUST00000020877.3 ENSMUST00000020877.4 ENSMUST00000020877.5 ENSMUST00000020877.6 ENSMUST00000020877.7 ENSMUST00000020877.8 NM_172253 Polr1f Q3U6L1 Q78WZ7 Q8CEP7 Q9CS60 RPA43_MOUSE Twistnb uc007niu.1 uc007niu.2 uc007niu.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters. Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity). Interacts with RRN3/TIF-IA. Nucleus, nucleolus Widely expressed. Belongs to the eukaryotic RPA43 RNA polymerase subunit family. Sequence=BAC25502.1; Type=Frameshift; Evidence=; DNA-directed 5'-3' RNA polymerase activity nucleus nucleolus DNA-directed RNA polymerase I complex transcription, DNA-templated transcription from RNA polymerase I promoter cellular response to leukemia inhibitory factor RNA polymerase I activity uc007niu.1 uc007niu.2 uc007niu.3 
ENSMUST00000020878.8 Efcab10 ENSMUST00000020878.8 EF-hand calcium binding domain 10 (from RefSeq NM_029152.1) EFC10_MOUSE ENSMUST00000020878.1 ENSMUST00000020878.2 ENSMUST00000020878.3 ENSMUST00000020878.4 ENSMUST00000020878.5 ENSMUST00000020878.6 ENSMUST00000020878.7 NM_029152 Q9D581 uc007nit.1 uc007nit.2 uc007nit.3 uc007nit.4 molecular_function calcium ion binding cellular_component biological_process uc007nit.1 uc007nit.2 uc007nit.3 uc007nit.4 
ENSMUST00000020885.13 Sypl1 ENSMUST00000020885.13 synaptophysin like 1, transcript variant 2 (from RefSeq NM_198710.3) ENSMUST00000020885.1 ENSMUST00000020885.10 ENSMUST00000020885.11 ENSMUST00000020885.12 ENSMUST00000020885.2 ENSMUST00000020885.3 ENSMUST00000020885.4 ENSMUST00000020885.5 ENSMUST00000020885.6 ENSMUST00000020885.7 ENSMUST00000020885.8 ENSMUST00000020885.9 NM_198710 Q3TVX7 Q3TVX7_MOUSE Sypl Sypl1 uc007nii.1 uc007nii.2 uc007nii.3 uc007nii.4 Membrane ; Multi- pass membrane protein Belongs to the synaptophysin/synaptobrevin family. synaptic vesicle membrane integral component of membrane uc007nii.1 uc007nii.2 uc007nii.3 uc007nii.4 
ENSMUST00000020886.9 Nampt ENSMUST00000020886.9 nicotinamide phosphoribosyltransferase (from RefSeq NM_021524.2) ENSMUST00000020886.1 ENSMUST00000020886.2 ENSMUST00000020886.3 ENSMUST00000020886.4 ENSMUST00000020886.5 ENSMUST00000020886.6 ENSMUST00000020886.7 ENSMUST00000020886.8 NAMPT_MOUSE NM_021524 Pbef1 Q8C3B5 Q99KQ4 Q9JKM0 uc007nif.1 uc007nif.2 uc007nif.3 uc007nif.4 The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma (By similarity). Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. Reaction=beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho- alpha-D-ribose 1-diphosphate + H(+) + nicotinamide; Xref=Rhea:RHEA:16149, ChEBI:CHEBI:14649, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017; EC=2.4.2.12; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:16151; Evidence=; Kinetic parameters: KM=0.92 uM for nicotinamide Vmax=0.021 umol/min/mg enzyme Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D- ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1. Homodimer. Q99KQ4; Q99KQ4: Nampt; NbExp=4; IntAct=EBI-8316571, EBI-8316571; Nucleus Cytoplasm Secreted Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100- fold higher concentrations compared to maternal serum. Ubiquitously expressed in lymphoid and non-lymphoid tissues. Expression shows a diurnal pattern of oscillation across the 24-hour light-dark cycle in liver, with a reduction in levels before the onset of the dark period (at protein level). Expression shows a diurnal pattern of oscillation in white adipose tissue (WAT), peaking at the beginning of the dark period. Up-regulated during polyclonal immune responses. Belongs to the NAPRTase family. microglial cell activation catalytic activity nicotinate-nucleotide diphosphorylase (carboxylating) activity cytokine activity extracellular region extracellular space nucleus cytoplasm cytosol plasma membrane signal transduction female pregnancy aging circadian rhythm drug binding NAD biosynthetic process negative regulation of autophagy response to organic cyclic compound regulation of lung blood pressure nuclear speck transferase activity transferase activity, transferring glycosyl groups pyridine nucleotide biosynthetic process cell junction circadian regulation of gene expression identical protein binding protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter nicotinamide phosphoribosyltransferase activity rhythmic process positive regulation of smooth muscle cell proliferation positive regulation of nitric-oxide synthase biosynthetic process neuron death cellular response to ionizing radiation cellular response to oxygen-glucose deprivation cellular response to beta-amyloid response to D-galactose negative regulation of cellular senescence uc007nif.1 uc007nif.2 uc007nif.3 uc007nif.4 
ENSMUST00000020896.17 Tspan13 ENSMUST00000020896.17 tetraspanin 13 (from RefSeq NM_025359.3) A7NSH9 ENSMUST00000020896.1 ENSMUST00000020896.10 ENSMUST00000020896.11 ENSMUST00000020896.12 ENSMUST00000020896.13 ENSMUST00000020896.14 ENSMUST00000020896.15 ENSMUST00000020896.16 ENSMUST00000020896.2 ENSMUST00000020896.3 ENSMUST00000020896.4 ENSMUST00000020896.5 ENSMUST00000020896.6 ENSMUST00000020896.7 ENSMUST00000020896.8 ENSMUST00000020896.9 NM_025359 Q3TMS0 Q8BTH3 Q9D8C2 TSN13_MOUSE Tm4sf13 uc007njn.1 uc007njn.2 uc007njn.3 Membrane ; Multi-pass membrane protein Belongs to the tetraspanin (TM4SF) family. calcium channel regulator activity protein binding plasma membrane membrane integral component of membrane regulation of calcium ion transmembrane transport uc007njn.1 uc007njn.2 uc007njn.3 
ENSMUST00000020898.12 Agr2 ENSMUST00000020898.12 anterior gradient 2 (from RefSeq NM_011783.2) A2CGA2 AGR2_MOUSE ENSMUST00000020898.1 ENSMUST00000020898.10 ENSMUST00000020898.11 ENSMUST00000020898.2 ENSMUST00000020898.3 ENSMUST00000020898.4 ENSMUST00000020898.5 ENSMUST00000020898.6 ENSMUST00000020898.7 ENSMUST00000020898.8 ENSMUST00000020898.9 Gob4 NM_011783 O88312 uc007njm.1 uc007njm.2 uc007njm.3 Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth (By similarity). Promotes cell adhesion (By similarity). Monomer and homodimer. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Secreted Endoplasmic reticulum Expressed in lung, skeletal muscle, testis, liver, stomach, colon, small intestine, the goblet cells of the intestine and the mucuous neck cells of the stomach. Expressed in embryo at 15 dpc onwards. Mice are viable but display altered production of mucus with loss of production of MUC2 despite expression of its mRNA. They also display an increase in mast cells in the intestine, an increased expression of inflammation-specific genes, and frequent rectal prolapse. This is associated with a higher susceptibility to colitis. Belongs to the AGR family. dystroglycan binding epidermal growth factor receptor binding extracellular region extracellular space mitochondrion endoplasmic reticulum positive regulation of gene expression positive regulation of cell-substrate adhesion protein homodimerization activity positive regulation of epidermal growth factor receptor signaling pathway digestive tract morphogenesis positive regulation of developmental growth lung goblet cell differentiation negative regulation of cell death mucus secretion positive regulation of protein localization to plasma membrane positive regulation of IRE1-mediated unfolded protein response positive regulation of PERK-mediated unfolded protein response uc007njm.1 uc007njm.2 uc007njm.3 
ENSMUST00000020899.5 Matn3 ENSMUST00000020899.5 matrilin 3 (from RefSeq NM_010770.4) ENSMUST00000020899.1 ENSMUST00000020899.2 ENSMUST00000020899.3 ENSMUST00000020899.4 MATN3_MOUSE NM_010770 O35701 Q543Q2 Q9JHM0 uc007nag.1 uc007nag.2 uc007nag.3 Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. Can form homooligomers (monomers, dimers, trimers and tetramers) and heterooligomers with matrilin-1. Interacts with COMP (By similarity). Component of a complex containing at least CRELD2, MANF, MATN3 and PDIA4 (PubMed:23956175). Secreted Strongly expressed in growing skeletal tissue such as epiphyseal growth plate or in bone undergoing growth and remodeling. In the bone, actively synthesized in osteoblasts and osteocytes. Expressed in cartilage of sternum, femur, vertebrae, trachea, articular and epiphyseal cartilage, cartilage of developing bones and bones. The earliest expression could be detected in a 12.5 dpc embryo in the cartilage anlage of the developing bones. At 14.5 dpc the primordial skeleton shows a strong expression. At birth present in the developing occipital bones, bones of the nasal cavity, manubrium and corpus of sternum as well as in the cartilage plates of trachea. At no stage of development detected in extraskeletal tissues. growth plate cartilage chondrocyte morphogenesis calcium ion binding extracellular region extracellular space extracellular matrix cartilage development uc007nag.1 uc007nag.2 uc007nag.3 
ENSMUST00000020904.8 Rock2 ENSMUST00000020904.8 Rho-associated coiled-coil containing protein kinase 2 (from RefSeq NM_009072.2) ENSMUST00000020904.1 ENSMUST00000020904.2 ENSMUST00000020904.3 ENSMUST00000020904.4 ENSMUST00000020904.5 ENSMUST00000020904.6 ENSMUST00000020904.7 F8VPK5 F8VPK5_MOUSE NM_009072 Rock2 uc007nch.1 uc007nch.2 uc007nch.3 Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Activated by RHOA binding. Inhibited by Y-27632. Homodimer. Cell membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Membrane ; Peripheral membrane protein Nucleus Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. nucleotide binding positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity ATP binding centrosome cytosol cytoskeleton protein phosphorylation smooth muscle contraction I-kappaB kinase/NF-kappaB signaling Rho protein signal transduction positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of centrosome duplication kinase activity phosphorylation negative regulation of angiogenesis transferase activity Rho GTPase binding peptidyl-serine phosphorylation peptidyl-threonine phosphorylation actin cytoskeleton organization positive regulation of cell migration cortical actin cytoskeleton organization regulation of actin cytoskeleton organization negative regulation of myosin-light-chain-phosphatase activity intracellular signal transduction cytoplasmic ribonucleoprotein granule viral RNA genome replication negative regulation of nitric oxide biosynthetic process regulation of keratinocyte differentiation metal ion binding centrosome duplication positive regulation of stress fiber assembly cellular response to testosterone stimulus Rho-dependent protein serine/threonine kinase activity protein localization to plasma membrane positive regulation of beta-amyloid formation positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process positive regulation of protein localization to early endosome positive regulation of amyloid precursor protein catabolic process regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly uc007nch.1 uc007nch.2 uc007nch.3 
ENSMUST00000020908.9 E2f6 ENSMUST00000020908.9 E2F transcription factor 6, transcript variant 1 (from RefSeq NM_033270.2) E2F6_MOUSE E2f6 ENSMUST00000020908.1 ENSMUST00000020908.2 ENSMUST00000020908.3 ENSMUST00000020908.4 ENSMUST00000020908.5 ENSMUST00000020908.6 ENSMUST00000020908.7 ENSMUST00000020908.8 NM_033270 O54917 Q8K456 uc007nce.1 uc007nce.2 uc007nce.3 uc007nce.4 Inhibitor of E2F-dependent transcription (PubMed:9403682). Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:9403682, PubMed:18667754). Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9403682). E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9403682). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (By similarity). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (PubMed:18667754). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity). Forms heterodimers with DP family members TFDP1 or TFDP2. Component of the DRTF1/E2F transcription factor complex. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Nucleus Belongs to the E2F/DP family. regulation of transcription involved in G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm DNA replication factor A complex transcription factor complex regulation of transcription, DNA-templated cell cycle transcription factor binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter protein dimerization activity regulation of cell cycle MLL1 complex RNA polymerase II transcription factor complex uc007nce.1 uc007nce.2 uc007nce.3 uc007nce.4 
ENSMUST00000020909.5 Laptm4a ENSMUST00000020909.5 lysosomal-associated protein transmembrane 4A (from RefSeq NM_008640.3) E9QLR3 ENSMUST00000020909.1 ENSMUST00000020909.2 ENSMUST00000020909.3 ENSMUST00000020909.4 Laptm4a NM_008640 Q8BG66 Q8BG66_MOUSE uc007naf.1 uc007naf.2 uc007naf.3 uc007naf.4 uc007naf.5 May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. Endomembrane system ; Multi-pass membrane protein Belongs to the LAPTM4/LAPTM5 transporter family. membrane integral component of membrane uc007naf.1 uc007naf.2 uc007naf.3 uc007naf.4 uc007naf.5 
ENSMUST00000020911.14 Sdc1 ENSMUST00000020911.14 syndecan 1 (from RefSeq NM_011519.2) ENSMUST00000020911.1 ENSMUST00000020911.10 ENSMUST00000020911.11 ENSMUST00000020911.12 ENSMUST00000020911.13 ENSMUST00000020911.2 ENSMUST00000020911.3 ENSMUST00000020911.4 ENSMUST00000020911.5 ENSMUST00000020911.6 ENSMUST00000020911.7 ENSMUST00000020911.8 ENSMUST00000020911.9 NM_011519 Q3V1F2 Q3V1F2_MOUSE Sdc1 uc007nac.1 uc007nac.2 uc007nac.3 uc007nac.4 Cell surface proteoglycan. Membrane ingle-pass type I membrane protein Secreted, extracellular exosome Belongs to the syndecan proteoglycan family. ureteric bud development inflammatory response protein C-terminus binding response to toxic substance cell surface response to organic substance membrane integral component of membrane macromolecular complex wound healing odontogenesis response to hydrogen peroxide identical protein binding response to glucocorticoid response to cAMP response to calcium ion striated muscle cell development Sertoli cell development positive regulation of exosomal secretion positive regulation of extracellular exosome assembly uc007nac.1 uc007nac.2 uc007nac.3 uc007nac.4 
ENSMUST00000020920.10 Rgs9 ENSMUST00000020920.10 regulator of G-protein signaling 9, transcript variant 1 (from RefSeq NM_011268.2) A1L352 ENSMUST00000020920.1 ENSMUST00000020920.2 ENSMUST00000020920.3 ENSMUST00000020920.4 ENSMUST00000020920.5 ENSMUST00000020920.6 ENSMUST00000020920.7 ENSMUST00000020920.8 ENSMUST00000020920.9 NM_011268 O54828 Q9Z0S0 RGS9_MOUSE uc007mbx.1 uc007mbx.2 uc007mbx.3 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction. Heterodimer with GNB5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (PubMed:15632198, PubMed:15897264). Component of the RGS9-1-Gbeta5 complex composed of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP (PubMed:12119397, PubMed:12499365, PubMed:14614075, PubMed:16908407). Interacts with PDE6G and GNAT1 (By similarity). [Isoform 1]: Membrane; Peripheral membrane protein. Note=Isoform 1 is targeted to the membrane via its interaction with RGS9BP. Event=Alternative splicing; Named isoforms=2; Name=2; Synonyms=RGS9-2; IsoId=O54828-1; Sequence=Displayed; Name=1; Synonyms=RGS9-1; IsoId=O54828-2; Sequence=VSP_005678, VSP_005679; Isoform 1 is expressed in photoreceptor outer segments. Isoform 2 is expressed in brain striatum. Retinal isoform 1 is light-dependent phosphorylated at 'Ser-475'. Phosphorylation is decreased by light exposition. Interaction with RGS9BP is decreased when isoform 1 is phosphorylated at 'Ser-475'. photoreceptor outer segment photoreceptor inner segment response to amphetamine GTPase activator activity protein binding nucleus cytoplasm G-protein coupled receptor signaling pathway dopamine receptor signaling pathway nervous system development visual perception regulation of G-protein coupled receptor protein signaling pathway negative regulation of signal transduction membrane response to estradiol intracellular signal transduction positive regulation of GTPase activity response to stimulus postsynaptic density membrane glutamatergic synapse positive regulation of NMDA glutamate receptor activity uc007mbx.1 uc007mbx.2 uc007mbx.3 
ENSMUST00000020922.8 Trib2 ENSMUST00000020922.8 tribbles pseudokinase 2, transcript variant 1 (from RefSeq NM_144551.6) ENSMUST00000020922.1 ENSMUST00000020922.2 ENSMUST00000020922.3 ENSMUST00000020922.4 ENSMUST00000020922.5 ENSMUST00000020922.6 ENSMUST00000020922.7 NM_144551 Q8K017 Q8K4K3 Q8R2V8 TRIB2_MOUSE Trib2 uc007nbq.1 uc007nbq.2 Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). Cytoplasm Cytoplasm, cytoskeleton Note=May associate with the cytoskeleton. The protein kinase domain is predicted to be catalytically inactive. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. protein kinase inhibitor activity nucleus cytoplasm cytoskeleton protein phosphorylation negative regulation of protein kinase activity transcription factor binding mitogen-activated protein kinase kinase binding ubiquitin protein ligase binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of MAP kinase activity negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of interleukin-10 biosynthetic process negative regulation of fat cell differentiation positive regulation of ubiquitin-protein transferase activity ubiquitin-protein transferase regulator activity nucleotide binding protein kinase activity uc007nbq.1 uc007nbq.2 
ENSMUST00000020926.8 Lratd1 ENSMUST00000020926.8 LRAT domain containing 1 (from RefSeq NM_029007.2) A0A0R4J012 A0A0R4J012_MOUSE ENSMUST00000020926.1 ENSMUST00000020926.2 ENSMUST00000020926.3 ENSMUST00000020926.4 ENSMUST00000020926.5 ENSMUST00000020926.6 ENSMUST00000020926.7 Fam84a Lratd1 NM_029007 uc007nbn.1 uc007nbn.2 uc007nbn.3 cell morphogenesis cell motility uc007nbn.1 uc007nbn.2 uc007nbn.3 
ENSMUST00000020927.10 Hs1bp3 ENSMUST00000020927.10 HCLS1 binding protein 3 (from RefSeq NM_021429.3) E9QLQ4 ENSMUST00000020927.1 ENSMUST00000020927.2 ENSMUST00000020927.3 ENSMUST00000020927.4 ENSMUST00000020927.5 ENSMUST00000020927.6 ENSMUST00000020927.7 ENSMUST00000020927.8 ENSMUST00000020927.9 H1BP3_MOUSE NM_021429 Q3TC93 Q9Z1K1 uc007mzo.1 uc007mzo.2 uc007mzo.3 uc007mzo.4 May be a modulator of IL-2 signaling. Binds HCLS1. Interacts with the SH3 domain of HCLS1 in vitro. Ubiquitously expressed. protein binding mitochondrion endoplasmic reticulum cell surface receptor signaling pathway T cell differentiation phosphatidylinositol binding regulation of apoptotic process uc007mzo.1 uc007mzo.2 uc007mzo.3 uc007mzo.4 
ENSMUST00000020928.13 Arsg ENSMUST00000020928.13 arylsulfatase G, transcript variant 1 (from RefSeq NM_028710.3) ARSG_MOUSE B1AT67 B1AT68 ENSMUST00000020928.1 ENSMUST00000020928.10 ENSMUST00000020928.11 ENSMUST00000020928.12 ENSMUST00000020928.2 ENSMUST00000020928.3 ENSMUST00000020928.4 ENSMUST00000020928.5 ENSMUST00000020928.6 ENSMUST00000020928.7 ENSMUST00000020928.8 ENSMUST00000020928.9 Kiaa1001 NM_028710 Q3TYD4 Q5XFU5 Q69ZT6 Q8CHS3 Q8VBZ5 Q9D3B4 uc007mcn.1 uc007mcn.2 uc007mcn.3 uc007mcn.4 Displays arylsulfatase activity at acidic pH towards the artificial substrate p-nitrocatechol sulfate (PubMed:25135642). Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D- glucosamine 3-O-sulfate units of heparin (PubMed:22689975). Reaction=an aryl sulfate + H2O = a phenol + H(+) + sulfate; Xref=Rhea:RHEA:17261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:33853, ChEBI:CHEBI:140317; EC=3.1.6.1; Evidence=; Reaction=Hydrolysis of the 3-sulfate groups of the N-sulfo-D- glucosamine 3-O-sulfate units of heparin.; EC=3.1.6.15; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Lysosome Note=The 63-kDa precursor protein localizes to pre-lysosomal compartments and tightly associates with organelle membranes, most likely the endoplasmic reticulum. In contrast, proteolytically processed fragments of 34-, 18- and 10-kDa are found in lysosomal fractions and lose their membrane association. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TYD4-1; Sequence=Displayed; Name=2; IsoId=Q3TYD4-2; Sequence=VSP_018628, VSP_018629; Highly expressed in the spleen, kidney, liver, brain, and testis (at protein level). N-glycosylated with both high mannose and complex type sugars. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. The 63-kDa precursor undergoes proteolytic processing in two steps, yielding two fragments in the first step (apparent molecular masses of 44 and 18 kDa). In the second step, the 44-kDa fragment is processed further to the 34- and 10-kDa chains. The 10-kDa chain is a cleavage product of the 44-kDa fragment but linked to the 18-kDa chain through a disulfide bridge. Mice accumulate heparan sulfate in visceral organs and the central nervous system and develop neuronal cell death and behavioral deficits (PubMed:22689975). This accumulated heparan sulfate exhibits unique non-reducing end structures with terminal N- sulfoglucosamine-3-O-sulfate residues (PubMed:22689975). Belongs to the sulfatase family. catalytic activity arylsulfatase activity extracellular space lysosome endoplasmic reticulum sulfur compound metabolic process sulfuric ester hydrolase activity hydrolase activity metal ion binding uc007mcn.1 uc007mcn.2 uc007mcn.3 uc007mcn.4 
ENSMUST00000020930.14 Gna13 ENSMUST00000020930.14 guanine nucleotide binding protein, alpha 13, transcript variant 1 (from RefSeq NM_010303.3) ENSMUST00000020930.1 ENSMUST00000020930.10 ENSMUST00000020930.11 ENSMUST00000020930.12 ENSMUST00000020930.13 ENSMUST00000020930.2 ENSMUST00000020930.3 ENSMUST00000020930.4 ENSMUST00000020930.5 ENSMUST00000020930.6 ENSMUST00000020930.7 ENSMUST00000020930.8 ENSMUST00000020930.9 GNA13_MOUSE Gna-13 NM_010303 P27601 Q6PF99 uc007mce.1 uc007mce.2 uc007mce.3 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:21212405, PubMed:19151758, PubMed:16388592). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:16388592). GNA13- dependent Rho signaling subsequently regulates transcription factor AP- 1 (activating protein-1) (PubMed:19151758, PubMed:21212405). Promotes tumor cell invasion and metastasis by activating Rho/ROCK signaling pathway (By similarity). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (By similarity). G proteins are composed of 3 units; alpha, beta and gamma (PubMed:16388592). The alpha chain contains the guanine nucleotide binding site (PubMed:16388592). Interacts with UBXD5 (By similarity). Interacts with HAX1 (By similarity). Interacts (in GTP-bound form) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane (By similarity). Interacts with RGS22 (By similarity). Interacts (in GTP-bound form) with ARHGEF1 (PubMed:16388592). Interacts (in GTP-bound form) with ARHGEF11 (via RGS domain) (PubMed:18940608). Interacts (in GTP-bound form) with ARHGEF12 (via RGS domain) (PubMed:16388592). Interacts with CTNND1 (PubMed:15240885). Interacts with GAS2L2 (PubMed:23994616). Interacts with GPR35 (By similarity). Interacts with GPR174 (PubMed:31875850). P27601; O08915: Aip; NbExp=3; IntAct=EBI-2255627, EBI-6935014; P27601; Q9ES67: Arhgef11; Xeno; NbExp=3; IntAct=EBI-2255627, EBI-15735216; Membrane ; Lipid- anchor Melanosome Cytoplasm Nucleus Note=Cytoplasmic in adult somatic cells, but mainly nuclear in spermatids in the testes. Translocates from the cytoplasm to the nucleus during spermatogenesis, hence predominantly observed in the cytoplasm of round spermatids but localized in the nuclei of elongating or elongated spermatids and testicular spermatozoa. Expressed in brain and testis, as well as in kidney and sperm (at protein level). Phosphorylation on Thr-203 destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation. Belongs to the G-alpha family. G(12) subfamily. nucleotide binding angiogenesis branching involved in blood vessel morphogenesis G-protein coupled receptor binding in utero embryonic development GTPase activity protein binding GTP binding nucleus cytoplasm cytosol heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration Rho protein signal transduction regulation of cell shape membrane guanyl nucleotide binding cell differentiation platelet activation regulation of cell migration brush border membrane activation of phospholipase D activity G-protein beta/gamma-subunit complex binding D5 dopamine receptor binding intracellular signal transduction melanosome metal ion binding uc007mce.1 uc007mce.2 uc007mce.3 
ENSMUST00000020931.6 Smc6 ENSMUST00000020931.6 structural maintenance of chromosomes 6, transcript variant 1 (from RefSeq NM_025695.4) ENSMUST00000020931.1 ENSMUST00000020931.2 ENSMUST00000020931.3 ENSMUST00000020931.4 ENSMUST00000020931.5 Kiaa4103 NM_025695 Q3UFI5 Q3UX54 Q499E1 Q5DTN2 Q8BFU9 Q8R0T4 Q924W5 Q9CSK7 Q9CV94 Q9CZZ5 Q9D169 Q9D6B2 SMC6_MOUSE Smc6l1 uc007nay.1 uc007nay.2 Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). Forms a heterodimer with SMC5. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. Interacts with NSMCE1. Interacts with NSMCE2. Interacts with SLF1. Interacts with SLF2. Interacts with RAD18. Interacts with SIMC1. Nucleus Nucleus speckle Chromosome Nucleus, PML body Chromosome, telomere Note=Localizes to PML nuclear bodies in ALT cell lines. Associates with chromatin. Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin- dependent manner. Localizes in interchromatin granule clusters (By similarity). Colocalizes with SMC5 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (PubMed:11408570). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q924W5-1; Sequence=Displayed; Name=2; IsoId=Q924W5-2; Sequence=VSP_022254, VSP_022255; The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer. Phosphorylated. Sumoylated by NSMCE2/MMS21. Ubiquitinated. Belongs to the SMC family. SMC6 subfamily. Sequence=BAB23051.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding telomere maintenance via recombination chromosome, telomeric region sex chromosome ATP binding nucleus nucleoplasm chromosome DNA repair DNA recombination cellular response to DNA damage stimulus PML body nuclear speck Smc5-Smc6 complex ubiquitin protein ligase binding interchromatin granule site of double-strand break positive regulation of chromosome segregation cellular senescence uc007nay.1 uc007nay.2 
ENSMUST00000020938.8 Fam20a ENSMUST00000020938.8 FAM20A, golgi associated secretory pathway pseudokinase (from RefSeq NM_153782.2) ENSMUST00000020938.1 ENSMUST00000020938.2 ENSMUST00000020938.3 ENSMUST00000020938.4 ENSMUST00000020938.5 ENSMUST00000020938.6 ENSMUST00000020938.7 FA20A_MOUSE Fam20a NM_153782 Q8CID3 uc007mcw.1 uc007mcw.2 uc007mcw.3 Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. Interacts with FAM20C; probably forming a heterotetramer of 2 subunits of FAM20A and 2 subunits of FAM20C. Secreted Golgi apparatus Endoplasmic reticulum In the mammary gland, expressed at higher levels in lactating mice than in virgin mice (PubMed:29858230). Observed throughout the tissues of the mandibular incisor, including the secretory and maturation stage ameloblasts, the suprabasal layers of the gingival epithelium and the odontoblasts. Weak expression in the enamel matrix. In EML and MPRO cell lines, low levels in undifferentiated cells. Induced during maturation to promyelocyte stage of neutrophil differentiation. Decreased during neutrophil terminal differentiation. By all-trans retinoic acid (atRA) and IL3 in EML cell line. N-glycosylated. Mice survive to adulthood and show biomineralization defects such as severe amelogenesis imperfecta (AI). In addition, mice develop disseminated calcifications of muscular arteries and intrapulmonary calcifications, similar to those of fetuin- A (Ahsg) deficient mice, although they are normocalcemic and normophosphatemic, with normal dentin and bone. Belongs to the FAM20 family. positive regulation of protein phosphorylation extracellular region extracellular space cell endoplasmic reticulum Golgi apparatus protein phosphorylation response to bacterium biomineral tissue development protein serine/threonine kinase activator activity tooth eruption calcium ion homeostasis enamel mineralization positive regulation of protein serine/threonine kinase activity protein serine/threonine kinase activity phosphotransferase activity, alcohol group as acceptor uc007mcw.1 uc007mcw.2 uc007mcw.3 
ENSMUST00000020941.11 1700012B07Rik ENSMUST00000020941.11 RIKEN cDNA 1700012B07 gene, transcript variant 2 (from RefSeq NM_027038.1) 1700012B07Rik ENSMUST00000020941.1 ENSMUST00000020941.10 ENSMUST00000020941.2 ENSMUST00000020941.3 ENSMUST00000020941.4 ENSMUST00000020941.5 ENSMUST00000020941.6 ENSMUST00000020941.7 ENSMUST00000020941.8 ENSMUST00000020941.9 NM_027038 Q9DAE9 Q9DAE9_MOUSE uc007mcy.1 uc007mcy.2 uc007mcy.3 uc007mcy.4 molecular_function cellular_component biological_process uc007mcy.1 uc007mcy.2 uc007mcy.3 uc007mcy.4 
ENSMUST00000020947.7 Rdh14 ENSMUST00000020947.7 retinol dehydrogenase 14 (all-trans and 9-cis) (from RefSeq NM_023697.2) ENSMUST00000020947.1 ENSMUST00000020947.2 ENSMUST00000020947.3 ENSMUST00000020947.4 ENSMUST00000020947.5 ENSMUST00000020947.6 NM_023697 Pan2 Q9ERI6 RDH14_MOUSE uc007nar.1 uc007nar.2 uc007nar.3 uc007nar.4 Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-retinol. Has no activity towards steroids. Reaction=all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH; Xref=Rhea:RHEA:25033, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.300; Evidence=; Reaction=11-cis-retinol + NADP(+) = 11-cis-retinal + H(+) + NADPH; Xref=Rhea:RHEA:54912, ChEBI:CHEBI:15378, ChEBI:CHEBI:16066, ChEBI:CHEBI:16302, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Reaction=9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH; Xref=Rhea:RHEA:54916, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78272, ChEBI:CHEBI:78273; Evidence=; Shows clear specificity for the pro-S hydrogen on C4 of NADPH and the pro-R hydrogen on C15 of retinols. Belongs to the short-chain dehydrogenases/reductases (SDR) family. mitochondrion endoplasmic reticulum alcohol dehydrogenase (NADP+) activity oxidoreductase activity retinol metabolic process NADP-retinol dehydrogenase activity oxidation-reduction process steroid dehydrogenase activity uc007nar.1 uc007nar.2 uc007nar.3 uc007nar.4 
ENSMUST00000020948.15 Abca8b ENSMUST00000020948.15 ATP-binding cassette, sub-family A member 8b, transcript variant 1 (from RefSeq NM_013851.4) A2AM55 ABC8B_MOUSE Abca8 Abca8b ENSMUST00000020948.1 ENSMUST00000020948.10 ENSMUST00000020948.11 ENSMUST00000020948.12 ENSMUST00000020948.13 ENSMUST00000020948.14 ENSMUST00000020948.2 ENSMUST00000020948.3 ENSMUST00000020948.4 ENSMUST00000020948.5 ENSMUST00000020948.6 ENSMUST00000020948.7 ENSMUST00000020948.8 ENSMUST00000020948.9 Kiaa0822 NM_013851 Q69ZY4 Q8BRQ1 Q8K440 Q9JL38 uc007mdb.1 uc007mdb.2 uc007mdb.3 uc007mdb.4 Mediates cholesterol and taurocholate efflux (PubMed:28882873). Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels (By similarity). Reaction=ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out); Xref=Rhea:RHEA:50052, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36257, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50053; Evidence=; Reaction=ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate; Xref=Rhea:RHEA:39051, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39052; Evidence=; Cholesterol efflux is increased by extracellularly applied taurocholate. Cell membrane ; Multi-pass membrane protein Basolateral cell membrane Note=Predominantly expressed on the sinusoidal plasma membrane in hepatocytes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K440-1; Sequence=Displayed; Name=2; IsoId=Q8K440-2; Sequence=VSP_020704; Expressed in heart, brain, lung, liver and skeletal muscle (PubMed:12532264). Highly expressed in the liver, and is also abundant in heart and skeletal muscle (PubMed:28882873). Highly expressed in liver (PubMed:29300488). Expressed during embryogenesis. Down-regulated by digoxin. Belongs to the ABC transporter superfamily. ABCA family. Sequence=BAD32312.1; Type=Erroneous initiation; Evidence=; nucleotide binding lipid transporter activity ATP binding mitochondrial inner membrane plasma membrane lipid transport membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances intracellular membrane-bounded organelle transmembrane transport uc007mdb.1 uc007mdb.2 uc007mdb.3 uc007mdb.4 
ENSMUST00000020949.12 Map2k6 ENSMUST00000020949.12 mitogen-activated protein kinase kinase 6, transcript variant 1 (from RefSeq NM_011943.3) ENSMUST00000020949.1 ENSMUST00000020949.10 ENSMUST00000020949.11 ENSMUST00000020949.2 ENSMUST00000020949.3 ENSMUST00000020949.4 ENSMUST00000020949.5 ENSMUST00000020949.6 ENSMUST00000020949.7 ENSMUST00000020949.8 ENSMUST00000020949.9 Map2k6 NM_011943 Q543Z5 Q543Z5_MOUSE uc007mdr.1 uc007mdr.2 uc007mdr.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. MAPK cascade nucleotide binding activation of MAPK activity positive regulation of protein phosphorylation response to ischemia protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity ATP binding nucleus cytosol protein phosphorylation apoptotic process protein kinase binding ovulation cycle process positive regulation of prostaglandin secretion response to drug positive regulation of apoptotic process positive regulation of nitric-oxide synthase biosynthetic process cellular response to sorbitol uc007mdr.1 uc007mdr.2 uc007mdr.3 
ENSMUST00000020957.13 Adi1 ENSMUST00000020957.13 acireductone dioxygenase 1 (from RefSeq NM_134052.2) ENSMUST00000020957.1 ENSMUST00000020957.10 ENSMUST00000020957.11 ENSMUST00000020957.12 ENSMUST00000020957.2 ENSMUST00000020957.3 ENSMUST00000020957.4 ENSMUST00000020957.5 ENSMUST00000020957.6 ENSMUST00000020957.7 ENSMUST00000020957.8 ENSMUST00000020957.9 MTND_MOUSE Mtcbp1 NM_134052 Q99JT9 uc007nfv.1 uc007nfv.2 uc007nfv.3 uc007nfv.4 Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (PubMed:26858196). Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2- keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway (PubMed:26858196). Ni- containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (PubMed:26858196). Also down-regulates cell migration mediated by MMP14 (By similarity). Reaction=1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4- methylsulfanyl-2-oxobutanoate + formate + 2 H(+); Xref=Rhea:RHEA:24504, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740, ChEBI:CHEBI:16723, ChEBI:CHEBI:49252; EC=1.13.11.54; Evidence=; Reaction=1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3- (methylsulfanyl)propanoate + CO + formate + 2 H(+); Xref=Rhea:RHEA:14161, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740, ChEBI:CHEBI:17245, ChEBI:CHEBI:49016, ChEBI:CHEBI:49252; EC=1.13.11.53; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Evidence=; Note=Binds either 1 Fe or Ni cation per monomer (PubMed:26858196). Iron-binding promotes an acireductone dioxygenase reaction producing 2- keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3- (methylsulfanyl)propanoate (PubMed:26858196). ; Kinetic parameters: KM=0.123 mM for 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one (using iron as cofactor) ; KM=0.44 mM for 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one (using cobalt as cofactor) ; KM=0.302 mM for 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one (using nickel as cofactor) ; Note=kcat is 114.3 sec(-1) with 1,2-dihydroxy-5-(methylsulfanyl)pent- 1-en-3-one as substrate (using iron as cofactor) (PubMed:26858196). kcat is 7.55 sec(-1) with 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en- 3-one as substrate (using cobalt as cofactor) (PubMed:26858196). kcat is 17.7 sec(-1) with 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one as substrate (using nickel as cofactor) (PubMed:26858196). ; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. Monomer. Interacts with MMP14. Cytoplasm Nucleus Cell membrane ; Peripheral membrane protein ; Cytoplasmic side te=Localizes to the plasma membrane when complexed to MMP14. Belongs to the acireductone dioxygenase (ARD) family. iron ion binding nucleus cytoplasm plasma membrane methionine metabolic process cellular amino acid biosynthetic process methionine biosynthetic process acireductone dioxygenase [iron(II)-requiring] activity membrane oxidoreductase activity L-methionine biosynthetic process from methylthioadenosine metal ion binding dioxygenase activity oxidation-reduction process uc007nfv.1 uc007nfv.2 uc007nfv.3 uc007nfv.4 
ENSMUST00000020958.9 Klhl29 ENSMUST00000020958.9 kelch-like 29 (from RefSeq NM_001164493.1) A6H646 ENSMUST00000020958.1 ENSMUST00000020958.2 ENSMUST00000020958.3 ENSMUST00000020958.4 ENSMUST00000020958.5 ENSMUST00000020958.6 ENSMUST00000020958.7 ENSMUST00000020958.8 KLH29_MOUSE Kbtbd9 Kiaa1921 NM_001164493 Q80T74 uc007myw.1 uc007myw.2 uc007myw.3 uc007myw.4 uc007myw.5 uc007myw.6 Although the complete sequence is not known with certainty, sequence shown here appears to be the most probable in accordance with human sequence ortholog. Sequence=AAI38284.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI45749.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC65854.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; uc007myw.1 uc007myw.2 uc007myw.3 uc007myw.4 uc007myw.5 uc007myw.6 
ENSMUST00000020959.9 Rnaseh1 ENSMUST00000020959.9 ribonuclease H1, transcript variant 3 (from RefSeq NR_186048.1) E9QLN8 E9QLN8_MOUSE ENSMUST00000020959.1 ENSMUST00000020959.2 ENSMUST00000020959.3 ENSMUST00000020959.4 ENSMUST00000020959.5 ENSMUST00000020959.6 ENSMUST00000020959.7 ENSMUST00000020959.8 NR_186048 Rnaseh1 uc007nft.1 uc007nft.2 uc007nft.3 uc007nft.4 Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Belongs to the RNase H family. magnesium ion binding nucleic acid binding nuclease activity endonuclease activity RNA-DNA hybrid ribonuclease activity hydrolase activity metal ion binding RNA phosphodiester bond hydrolysis, endonucleolytic uc007nft.1 uc007nft.2 uc007nft.3 uc007nft.4 
ENSMUST00000020962.12 Ubxn2a ENSMUST00000020962.12 UBX domain protein 2A (from RefSeq NM_145441.4) ENSMUST00000020962.1 ENSMUST00000020962.10 ENSMUST00000020962.11 ENSMUST00000020962.2 ENSMUST00000020962.3 ENSMUST00000020962.4 ENSMUST00000020962.5 ENSMUST00000020962.6 ENSMUST00000020962.7 ENSMUST00000020962.8 ENSMUST00000020962.9 NM_145441 Q99KJ0 UBX2A_MOUSE Ubxd4 Ubxn2a uc007myr.1 uc007myr.2 uc007myr.3 Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons (PubMed:19474315). Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation (PubMed:19474315). Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9 (By similarity). Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway (By similarity). Part of a complex composed of STUB1/CHIP, VCP/p97, CHRNA3, and UBXN2A that modulates the ubiquitination and endoplasmic reticulum- associated degradation (ERAD) of CHRNA3 (By similarity). Within the complex UBXN2A acts as a scaffold protein required for the interaction of CHRNA3 with VCP/p97, this interaction also inhibits CHRNA3 ubiquitination by STUB1/CHIP and subsequently ERAD (PubMed:19474315). Interacts (via SEP domain) with CHRNA3 and interacts (via UBX domain) with VCP/P97; these interactions are required for the interaction of CHRNA3 with the STUB1-VCP-UBXN2A complex (PubMed:19474315). Interacts with HSPA9/MOT-2 (via SBD domain); the interaction inhibits HSPA9/MOT-2 interaction with and degradation of p53, thereby promotes p53 translocation to the nucleus (By similarity). Interacts with RICTOR (By similarity). Golgi apparatus Endoplasmic reticulum Perikaryon Cell projection, dendrite Nucleus Cytoplasm Note=Expressed at the axon initial segment. Expressed in the prefrontal cortex (at protein level) (PubMed:19474315, PubMed:26265139). Expressed in the habenula and hippocampus (at protein level) (PubMed:19474315). Expressed in peripheral ganglia (PubMed:19474315). Ubiquitinated. Knockout mice are embryonically lethal. autophagosome assembly endoplasmic reticulum cis-Golgi network cytosol Golgi organization regulation of gene expression regulation of protein ubiquitination nuclear envelope reassembly acetylcholine receptor binding regulation of protein catabolic process ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process membrane fusion cellular response to leukemia inhibitory factor uc007myr.1 uc007myr.2 uc007myr.3 
ENSMUST00000020964.7 Fkbp1b ENSMUST00000020964.7 FK506 binding protein 1b, transcript variant 5 (from RefSeq NR_166125.1) ENSMUST00000020964.1 ENSMUST00000020964.2 ENSMUST00000020964.3 ENSMUST00000020964.4 ENSMUST00000020964.5 ENSMUST00000020964.6 FKB1B_MOUSE NR_166125 Q9Z2I2 uc007myj.1 uc007myj.2 uc007myj.3 Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Inhibited by both FK506 and rapamycin. Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with RYR2 (By similarity). Q9Z2I2; E9Q401: Ryr2; NbExp=3; IntAct=EBI-6379859, EBI-643628; Cytoplasm Sarcoplasmic reticulum Belongs to the FKBP-type PPIase family. FKBP1 subfamily. protein peptidyl-prolyl isomerization regulation of heart rate peptidyl-prolyl cis-trans isomerase activity receptor binding protein binding FK506 binding cytoplasm smooth muscle contraction positive regulation of cytosolic calcium ion concentration response to glucose response to organic substance negative regulation of heart rate regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion membrane sarcoplasmic reticulum isomerase activity neuronal action potential propagation calcium channel inhibitor activity Z disc insulin secretion cyclic nucleotide binding negative regulation of phosphoprotein phosphatase activity sarcoplasmic reticulum membrane response to vitamin E calcium channel complex T cell proliferation response to hydrogen peroxide intracellular membrane-bounded organelle ion channel binding positive regulation of axon regeneration release of sequestered calcium ion into cytosol negative regulation of release of sequestered calcium ion into cytosol positive regulation of sequestering of calcium ion regulation of cytosolic calcium ion concentration response to redox state regulation of ryanodine-sensitive calcium-release channel activity negative regulation of ryanodine-sensitive calcium-release channel activity chaperone-mediated protein folding negative regulation of insulin secretion involved in cellular response to glucose stimulus uc007myj.1 uc007myj.2 uc007myj.3 
ENSMUST00000020965.14 Allc ENSMUST00000020965.14 allantoicase, transcript variant 1 (from RefSeq NM_053156.3) ALLC_MOUSE Allc E9QL21 ENSMUST00000020965.1 ENSMUST00000020965.10 ENSMUST00000020965.11 ENSMUST00000020965.12 ENSMUST00000020965.13 ENSMUST00000020965.2 ENSMUST00000020965.3 ENSMUST00000020965.4 ENSMUST00000020965.5 ENSMUST00000020965.6 ENSMUST00000020965.7 ENSMUST00000020965.8 ENSMUST00000020965.9 NM_053156 Q9JHX6 uc007nfp.1 uc007nfp.2 uc007nfp.3 uc007nfp.4 uc007nfp.5 uc007nfp.6 The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals. Belongs to the allantoicase family. allantoin metabolic process allantoin catabolic process allantoicase activity cellular_component hydrolase activity uc007nfp.1 uc007nfp.2 uc007nfp.3 uc007nfp.4 uc007nfp.5 uc007nfp.6 
ENSMUST00000020969.5 Cmpk2 ENSMUST00000020969.5 cytidine/uridine monophosphate kinase 2 (from RefSeq NM_020557.4) CMPK2_MOUSE ENSMUST00000020969.1 ENSMUST00000020969.2 ENSMUST00000020969.3 ENSMUST00000020969.4 NM_020557 Q3U5Q7 Q3UCI7 Q5XKG5 Q62316 Q6PFG7 Q9DC34 Tyki uc007nfj.1 uc007nfj.2 uc007nfj.3 Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways. Restricts the replication of multiple viruses including flaviviruses or coronaviruses. Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities (By similarity). Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity (By similarity). Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP while CMP and UMP are poor substrates. Controls therefore mitochondrial DNA synthesis by supplying required deoxyribonucleotides (PubMed:36443312). CMPK2-dependent mitochondrial DNA synthesis is necessary for the production of oxidized mitochondrial DNA fragments after exposure to NLRP3 activators (PubMed:30046112). In turn, cytosolic oxidized mtDNA associates with the NLRP3 inflammasome complex and is required for its activation (PubMed:30046112). Reaction=ATP + CMP = ADP + CDP; Xref=Rhea:RHEA:11600, ChEBI:CHEBI:30616, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.4.14; Reaction=ATP + dCMP = ADP + dCDP; Xref=Rhea:RHEA:25094, ChEBI:CHEBI:30616, ChEBI:CHEBI:57566, ChEBI:CHEBI:58593, ChEBI:CHEBI:456216; EC=2.7.4.14; Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Mitochondrion Strongly expressed in the brain. By lipopolysaccharides in macrophages and in primary microglia. Deletion mutant mice display calcification deposits in the brain. Neurons show reduced mitochondrial DNA copy number and impaired phosphorus and energy homeostasis, suggesting that dysregulation of mitochondrial function may promote the initiation and progressive development of brain calcification. Belongs to the thymidylate kinase family. Sequence=AAA58770.1; Type=Miscellaneous discrepancy; Note=Sequence differs due to frameshifts, sequencing errors and other discrepancies.; Evidence=; Sequence=AAH27329.1; Type=Erroneous initiation; Evidence=; Sequence=AAH57565.1; Type=Erroneous initiation; Evidence=; Sequence=BAB23396.1; Type=Frameshift; Evidence=; Sequence=BAE29625.1; Type=Erroneous initiation; Evidence=; Sequence=BAE29646.1; Type=Erroneous initiation; Evidence=; Sequence=BAE29803.1; Type=Erroneous initiation; Evidence=; Sequence=BAE29932.1; Type=Erroneous initiation; Evidence=; Sequence=BAE31987.1; Type=Erroneous initiation; Evidence=; nucleotide binding cytidylate kinase activity nucleoside diphosphate kinase activity thymidylate kinase activity ATP binding cytoplasm mitochondrion nucleoside diphosphate phosphorylation pyrimidine nucleotide biosynthetic process dUDP biosynthetic process dTDP biosynthetic process dTTP biosynthetic process uridylate kinase activity nucleoside triphosphate biosynthetic process kinase activity phosphorylation transferase activity UMP kinase activity nucleoside monophosphate phosphorylation nucleoside phosphate kinase activity cellular response to lipopolysaccharide uc007nfj.1 uc007nfj.2 uc007nfj.3 
ENSMUST00000020970.10 Rsad2 ENSMUST00000020970.10 radical S-adenosyl methionine domain containing 2 (from RefSeq NM_021384.4) ENSMUST00000020970.1 ENSMUST00000020970.2 ENSMUST00000020970.3 ENSMUST00000020970.4 ENSMUST00000020970.5 ENSMUST00000020970.6 ENSMUST00000020970.7 ENSMUST00000020970.8 ENSMUST00000020970.9 NM_021384 Q3U5I6 Q3U5T4 Q3U622 Q3U627 Q3U7I6 Q3U7M1 Q3U8F4 Q3U8U7 Q3U941 Q3U977 Q3U9E1 Q3U9J0 Q3U9J3 Q3UBW6 Q3UC07 Q3UDI0 Q6PEU4 Q8CBB9 Q8VHM2 Q9JHD4 RSAD2_MOUSE Rsad2 Vig1 uc007nfh.1 uc007nfh.2 uc007nfh.3 uc007nfh.4 Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA- dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses (By similarity). Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins (By similarity) (PubMed:17686841, PubMed:19047684, PubMed:21435586, PubMed:21880757). Reaction=AH2 + CTP + S-adenosyl-L-methionine = 3'-deoxy-3',4'- didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine; Xref=Rhea:RHEA:65944, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319, ChEBI:CHEBI:17499, ChEBI:CHEBI:37563, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:166821; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence= Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. IRAK1 and TRAF6 synergistically activate RSAD2 increasing its activity with CTP as substrate about 10-fold. Homodimer. Interacts with IRAK1 and TRAF6 (PubMed:21435586). Interacts with FPPS. Interacts with HADHB. Interacts (via C-terminus) with VAPA/VAP33 (via C-terminus) (By similarity). Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus Endoplasmic reticulum Lipid droplet Mitochondrion Mitochondrion inner membrane Mitochondrion outer membrane Expressed at higher levels in atherosclerotic arteries than in normal arteries. By interferon type I, type II and LPS. Induced by infection with Vesicular stomatitis virus and pseudorabies virus in dendritic cells, presumably through type I interferon pathway. The N-terminal region (1-43) is necessary for its localization to the endoplasmic reticulum membrane and lipid droplet. Acetylated by HAT1. HAT1-mediated acetylation of Lys-198 in turn recruits UBE4A that stimulates RSAD2 polyubiquitination leading to proteasomal degradation. 'Lys-6'-linked polyubiquitination at Lys-207 leads to RSAD2 protein degradation. Belongs to the radical SAM superfamily. RSAD2 family. Sequence=BAE29281.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; ossification fibrillar center immune system process molecular_function catalytic activity protein binding mitochondrion mitochondrial outer membrane mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum membrane lipid particle response to virus membrane regulation of ossification positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 9 signaling pathway CD4-positive, alpha-beta T cell activation CD4-positive, alpha-beta T cell differentiation protein self-association negative regulation of viral genome replication innate immune response metal ion binding negative regulation of protein secretion iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding defense response to virus positive regulation of T-helper 2 cell cytokine production uc007nfh.1 uc007nfh.2 uc007nfh.3 uc007nfh.4 
ENSMUST00000020971.14 Rnf144a ENSMUST00000020971.14 ring finger protein 144A, transcript variant 9 (from RefSeq NM_001413486.1) ENSMUST00000020971.1 ENSMUST00000020971.10 ENSMUST00000020971.11 ENSMUST00000020971.12 ENSMUST00000020971.13 ENSMUST00000020971.2 ENSMUST00000020971.3 ENSMUST00000020971.4 ENSMUST00000020971.5 ENSMUST00000020971.6 ENSMUST00000020971.7 ENSMUST00000020971.8 ENSMUST00000020971.9 Kiaa0161 NM_001413486 Q3UZZ0 Q6A0B4 Q925F3 R144A_MOUSE Rnf144 Ubce7ip4 Uip4 uc007nff.1 uc007nff.2 uc007nff.3 uc007nff.4 E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC. Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence=; Protein modification; protein ubiquitination. Interacts with UBE2L3. Cell membrane ; Single-pass membrane protein Cytoplasmic vesicle membrane Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT- type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain. Autoubiquitinated. Belongs to the RBR family. RNF144 subfamily. Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family. Sequence=BAD32182.1; Type=Erroneous initiation; Evidence=; ubiquitin ligase complex protein polyubiquitination ubiquitin-protein transferase activity cytoplasm Golgi apparatus plasma membrane ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination transferase activity cytoplasmic vesicle membrane cytoplasmic vesicle ubiquitin conjugating enzyme binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process intracellular membrane-bounded organelle metal ion binding ubiquitin protein ligase activity uc007nff.1 uc007nff.2 uc007nff.3 uc007nff.4 
ENSMUST00000020977.4 Dus4l ENSMUST00000020977.4 dihydrouridine synthase 4 like, transcript variant 7 (from RefSeq NR_184679.1) A0A0R4J016 A0A0R4J016_MOUSE Dus4l ENSMUST00000020977.1 ENSMUST00000020977.2 ENSMUST00000020977.3 NR_184679 uc007nhr.1 uc007nhr.2 uc007nhr.3 Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence= Belongs to the dus family. tRNA dihydrouridine synthesis catalytic activity tRNA processing oxidoreductase activity tRNA dihydrouridine synthase activity flavin adenine dinucleotide binding oxidation-reduction process uc007nhr.1 uc007nhr.2 uc007nhr.3 
ENSMUST00000020980.12 Rrm2 ENSMUST00000020980.12 ribonucleotide reductase M2 (from RefSeq NM_009104.2) ENSMUST00000020980.1 ENSMUST00000020980.10 ENSMUST00000020980.11 ENSMUST00000020980.2 ENSMUST00000020980.3 ENSMUST00000020980.4 ENSMUST00000020980.5 ENSMUST00000020980.6 ENSMUST00000020980.7 ENSMUST00000020980.8 ENSMUST00000020980.9 NM_009104 P11157 Q3UI23 Q542E2 RIR2_MOUSE uc007ner.1 uc007ner.2 uc007ner.3 uc007ner.4 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity). Reaction=[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'- diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'- diphosphate; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57930, ChEBI:CHEBI:73316; EC=1.17.4.1; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 2 iron ions per subunit.; Heterodimer of a large and a small subunit. Interacts (via Cy motif and when phosphorylated at Thr-33) with CCNF; the interaction occurs exclusively in G2 and early M (By similarity). Cytoplasm Nucleus Note=Localized to the cytoplasm in S phase cells. May localize to the nucleus in G2 phase cells. Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling (By similarity). Phosphorylated on Thr-33 by CDK1 and CDK2; predominantly in G2 and M phase (By similarity). Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex; leading to its degradation by the proteasome. Two distinct regulatory sites have been defined: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate- binding catalytic site, located on M1, is formed only in the presence of the second subunit M2. Belongs to the ribonucleoside diphosphate reductase small chain family. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor protein binding nuclear envelope cytoplasm cytosol ribonucleoside-diphosphate reductase complex DNA replication ferric iron binding deoxyribonucleotide metabolic process deoxyribonucleotide biosynthetic process oxidoreductase activity protein homodimerization activity metal ion binding protein heterotetramerization oxidation-reduction process uc007ner.1 uc007ner.2 uc007ner.3 uc007ner.4 
ENSMUST00000020982.7 Klf11 ENSMUST00000020982.7 Kruppel-like transcription factor 11 (from RefSeq NM_178357.3) ENSMUST00000020982.1 ENSMUST00000020982.2 ENSMUST00000020982.3 ENSMUST00000020982.4 ENSMUST00000020982.5 ENSMUST00000020982.6 KLF11_MOUSE Klf11 NM_178357 Q8BHJ1 Q8BI37 Q8BI70 Q8K1S5 Tieg2b Tieg3 uc007neo.1 uc007neo.2 uc007neo.3 uc007neo.4 Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding sites inhibiting cell growth (By similarity). Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. Interacts with SIN3A. Nucleus By TGF-beta. Expressed in a circadian manner in the kidney and epididymal fat tissue. Mice breed normally and are fertile. Hematopoiesis at all stages of development is normal and there is no effect on globin gene expression or longevity. Belongs to the Sp1 C2H2-type zinc-finger protein family. Sequence=BAC34099.1; Type=Frameshift; Evidence=; regulation of transcription involved in G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol focal adhesion regulation of transcription from RNA polymerase II promoter apoptotic process negative regulation of cell proliferation nuclear body positive regulation of apoptotic process transcription regulatory region DNA binding negative regulation of transcription, DNA-templated metal ion binding cellular response to peptide hemopoiesis uc007neo.1 uc007neo.2 uc007neo.3 uc007neo.4 
ENSMUST00000020986.15 Dnajc27 ENSMUST00000020986.15 DnaJ heat shock protein family (Hsp40) member C27 (from RefSeq NM_153082.4) DJC27_MOUSE ENSMUST00000020986.1 ENSMUST00000020986.10 ENSMUST00000020986.11 ENSMUST00000020986.12 ENSMUST00000020986.13 ENSMUST00000020986.14 ENSMUST00000020986.2 ENSMUST00000020986.3 ENSMUST00000020986.4 ENSMUST00000020986.5 ENSMUST00000020986.6 ENSMUST00000020986.7 ENSMUST00000020986.8 ENSMUST00000020986.9 NM_153082 Q8BX00 Q8CFP6 Q923I0 Rabj Rbj uc007mxj.1 uc007mxj.2 uc007mxj.3 uc007mxj.4 GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms). Q8CFP6; P31938: Map2k1; NbExp=3; IntAct=EBI-9548773, EBI-298860; Nucleus Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity protein binding GTP binding nucleus mitochondrion intracellular protein transport Rab protein signal transduction positive regulation of MAPK cascade positive regulation of ERK1 and ERK2 cascade regulation of MAPK export from nucleus uc007mxj.1 uc007mxj.2 uc007mxj.3 uc007mxj.4 
ENSMUST00000020990.7 Pomc ENSMUST00000020990.7 pro-opiomelanocortin-alpha, transcript variant 4 (from RefSeq NM_008895.4) COLI_MOUSE ENSMUST00000020990.1 ENSMUST00000020990.2 ENSMUST00000020990.3 ENSMUST00000020990.4 ENSMUST00000020990.5 ENSMUST00000020990.6 NM_008895 P01193 P01200 Pomc1 Q544U4 uc007mxe.1 uc007mxe.2 uc007mxe.3 uc007mxe.4 This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing. Processing yields several biologically active peptides, which are involved in diverse cellular functions, such as energy homeostasis, steroidogenesis, and increased melanin production in melanocytes. In mouse deficiency of this gene is associated with obesity, defects in adrenal development, and altered pigmentation. A pseudogene of this gene is located on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. [Met-enkephalin]: Endogenous opiate. Secreted Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms. ACTH and MSH are produced by the pituitary gland. [Beta-endorphin]: In hypothalamic paraventricular nucleus (PVN), up-regulated by cannabinoids, including the CNR1/CB1R agonist arachidonyl-29-chloroethylamide (ACEA) (at protein level). Specific enzymatic cleavages at paired basic residues yield the different active peptides. Belongs to the POMC family. G-protein coupled receptor binding receptor binding hormone activity protein binding extracellular region extracellular space cytoplasm peroxisomal matrix generation of precursor metabolites and energy signal transduction neuropeptide signaling pathway cell-cell signaling regulation of blood pressure secretory granule killing of cells of other organism type 3 melanocortin receptor binding type 4 melanocortin receptor binding regulation of appetite negative regulation of tumor necrosis factor production cellular pigmentation modification of morphology or physiology of other organism glucose homeostasis positive regulation of transcription from RNA polymerase II promoter regulation of glycogen metabolic process positive regulation of neutrophil mediated killing of fungus type 1 melanocortin receptor binding regulation of corticosterone secretion uc007mxe.1 uc007mxe.2 uc007mxe.3 uc007mxe.4 
ENSMUST00000020991.15 Dnmt3a ENSMUST00000020991.15 DNA methyltransferase 3A, transcript variant 1 (from RefSeq NM_007872.5) DNM3A_MOUSE Dnmt3a ENSMUST00000020991.1 ENSMUST00000020991.10 ENSMUST00000020991.11 ENSMUST00000020991.12 ENSMUST00000020991.13 ENSMUST00000020991.14 ENSMUST00000020991.2 ENSMUST00000020991.3 ENSMUST00000020991.4 ENSMUST00000020991.5 ENSMUST00000020991.6 ENSMUST00000020991.7 ENSMUST00000020991.8 ENSMUST00000020991.9 NM_007872 O88508 Q3TZK8 Q3UH24 Q8CJ60 Q922J0 Q9CSE1 uc007mxb.1 uc007mxb.2 uc007mxb.3 This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]. Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477). DNA methylation is coordinated with methylation of histones (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (PubMed:18823905). Plays a role in paternal and maternal imprinting (PubMed:15215868). Required for methylation of most imprinted loci in germ cells (PubMed:15215868). Acts as a transcriptional corepressor for ZBTB18 (PubMed:11350943). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (PubMed:20547484). Can actively repress transcription through the recruitment of HDAC activity (PubMed:11350943). Also has weak auto- methylation activity on Cys-706 in absence of DNA (PubMed:21481189). Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5- methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13682; Evidence=; Reaction=L-cysteinyl-[protein] + S-adenosyl-L-methionine = H(+) + S- adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:66544, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:10132, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:82612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66545; Evidence=; Activated by binding to the regulatory factor DNMT3L (PubMed:15671018, PubMed:17713477, PubMed:21481189). Auto- methylation at Cys-706 in absence of DNA inactivates the DNA methyltransferase activity (PubMed:21481189). Heterotetramer composed of 1 DNMT3A homodimer and 2 DNMT3L subunits (DNMT3L-DNMT3A-DNMT3A-DNMT3L) (By similarity). Interacts with DNMT1 and DNMT3B (By similarity). Interacts with MPHOSPH8 (By similarity). Interacts with histone H3 that is not methylated at 'Lys- 4' (H3K4) (By similarity). Binds the ZBTB18 transcriptional repressor (PubMed:11350943). Interacts with SETDB1 (By similarity). Associates with HDAC1 through its ADD domain (PubMed:11350943, PubMed:12616525). Interacts with UHRF1 (PubMed:19798101). Interacts with the PRC2/EED- EZH2 complex (PubMed:16357870). Interacts with UBC9, PIAS1 and PIAS2 (PubMed:14752048). Interacts with SPOCD1 (PubMed:32674113). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (By similarity). O88508; Q9CWR8: Dnmt3l; NbExp=6; IntAct=EBI-995154, EBI-3043871; O88508; Q60848: Hells; NbExp=4; IntAct=EBI-995154, EBI-3043887; O88508; P51608-1: MECP2; Xeno; NbExp=10; IntAct=EBI-995154, EBI-26687319; O88508-1; Q9CWR8: Dnmt3l; NbExp=6; IntAct=EBI-15650457, EBI-3043871; O88508-1; Q9Z148-2: Ehmt2; NbExp=3; IntAct=EBI-15650457, EBI-15737169; Nucleus romosome Cytoplasm Note=Accumulates in the major satellite repeats at pericentric heterochromatin. Event=Alternative promoter usage; Named isoforms=2; Name=1; IsoId=O88508-1; Sequence=Displayed; Name=2; IsoId=O88508-2; Sequence=VSP_009423; Isoform 1 is expressed ubiquitously at low levels. Expression of isoform 2 is restricted to tissues containing cells which are undergoing active de novo methylation, including spleen, testis and thymus. At 7.5 dpc, the protein is moderately expressed in embryonic ectoderm and weakly in mesodermal cells. At 8.5 dpc and 9.5 dpc, the expression become ubiquitous with an increase in the somites and in the ventral part of the embryo. The PWWP domain is essential for targeting to pericentric heterochromatin. It specifically recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20547484). Auto-methylated at Cys-706: auto-methylation takes place in absence of DNA substrate and inactivates the DNA methyltransferase activity (PubMed:21481189). Inactivation by auto-methylation may be used to inactivate unused DNA methyltransferases in the cell (PubMed:21481189). Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. Sequence=BAB28644.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter mitotic cell cycle chromosome, centromeric region euchromatin heterochromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding XY body DNA binding chromatin binding DNA (cytosine-5-)-methyltransferase activity protein binding nucleus nucleoplasm nuclear heterochromatin cytoplasm DNA methylation chromatin organization methylation-dependent chromatin silencing regulation of gene expression by genetic imprinting spermatogenesis aging transcription factor binding methyltransferase activity DNA-methyltransferase activity response to toxic substance response to ionizing radiation maintenance of DNA methylation response to lead ion regulation of gene expression positive regulation of cell death nuclear matrix transferase activity neuron differentiation response to nutrient levels methylation response to estradiol DNA methylation on cytosine response to vitamin A response to cocaine response to drug identical protein binding DNA methylation involved in embryo development DNA methylation involved in gamete generation hypermethylation of CpG island response to ethanol metal ion binding DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates cellular response to amino acid stimulus cellular response to ethanol cellular response to hypoxia C-5 methylation of cytosine hepatocyte apoptotic process uc007mxb.1 uc007mxb.2 uc007mxb.3 
ENSMUST00000020997.15 Sh3yl1 ENSMUST00000020997.15 Sh3 domain YSC-like 1, transcript variant 4 (from RefSeq NR_186254.1) ENSMUST00000020997.1 ENSMUST00000020997.10 ENSMUST00000020997.11 ENSMUST00000020997.12 ENSMUST00000020997.13 ENSMUST00000020997.14 ENSMUST00000020997.2 ENSMUST00000020997.3 ENSMUST00000020997.4 ENSMUST00000020997.5 ENSMUST00000020997.6 ENSMUST00000020997.7 ENSMUST00000020997.8 ENSMUST00000020997.9 NR_186254 O08641 Q6P7V3 Q6PDR3 SH3Y1_MOUSE uc007ngz.1 uc007ngz.2 uc007ngz.3 uc007ngz.4 Interacts with SH3D19. O08641; Q91X43: Sh3d19; NbExp=3; IntAct=EBI-2024519, EBI-2024543; Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O08641-1; Sequence=Displayed; Name=2; IsoId=O08641-2; Sequence=VSP_034336; Name=3; IsoId=O08641-3; Sequence=VSP_034337; Expressed in skin, kidney, stomach, small intestine and colon. Highly expressed in the anagen hair follicle. In hair, it is expressed predominantly in the hair bulb, the hair shaft, inner root sheath, and outer root sheath in the lower half of the follicle. In skin, expression follows hair-growth cycle, increasing significantly during mid and late anagen phases, and decreases during catagen, telogen and early anagen phases. Belongs to the SH3YL1 family. protein binding phosphatidylinositol biosynthetic process phosphatase binding ruffle membrane phosphatidylinositol binding regulation of ruffle assembly uc007ngz.1 uc007ngz.2 uc007ngz.3 uc007ngz.4 
ENSMUST00000020999.7 Kif3c ENSMUST00000020999.7 kinesin family member 3C (from RefSeq NM_008445.2) ENSMUST00000020999.1 ENSMUST00000020999.2 ENSMUST00000020999.3 ENSMUST00000020999.4 ENSMUST00000020999.5 ENSMUST00000020999.6 KIF3C_MOUSE NM_008445 O35066 O35229 Q3UH55 uc007mwm.1 uc007mwm.2 uc007mwm.3 Microtubule-based anterograde translocator for membranous organelles. Heterodimer of KIF3A and KIF3C. Cytoplasm, cytoskeleton Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. nucleotide binding microtubule motor activity protein binding ATP binding cytoplasm cytosol cytoskeleton kinesin complex microtubule microtubule-based movement microtubule binding synaptic vesicle positive regulation of neuron projection development membrane ATPase activity kinesin binding axon dendrite growth cone microtubule plus-end neuronal cell body neuronal ribonucleoprotein granule organelle transport along microtubule uc007mwm.1 uc007mwm.2 uc007mwm.3 
ENSMUST00000021001.10 Rab10 ENSMUST00000021001.10 RAB10, member RAS oncogene family (from RefSeq NM_016676.5) ENSMUST00000021001.1 ENSMUST00000021001.2 ENSMUST00000021001.3 ENSMUST00000021001.4 ENSMUST00000021001.5 ENSMUST00000021001.6 ENSMUST00000021001.7 ENSMUST00000021001.8 ENSMUST00000021001.9 NM_016676 Q4FJL0 Q4FJL0_MOUSE Rab10 uc007mwl.1 uc007mwl.2 uc007mwl.3 Cytoplasmic vesicle, phagosome membrane Golgi apparatus, trans-Golgi network membrane Membrane ; Lipid-anchor ; Cytoplasmic side Recycling endosome membrane Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding endosome endoplasmic reticulum membrane Golgi apparatus plasma membrane cilium endosomal transport GDP binding antigen processing and presentation myosin V binding insulin-responsive compartment regulated exocytosis recycling endosome exocytic vesicle endoplasmic reticulum tubular network endoplasmic reticulum tubular network organization establishment of protein localization to membrane establishment of protein localization to endoplasmic reticulum membrane uc007mwl.1 uc007mwl.2 uc007mwl.3 
ENSMUST00000021004.14 Sntg2 ENSMUST00000021004.14 syntrophin, gamma 2, transcript variant 5 (from RefSeq NR_136915.1) B2RSQ0 ENSMUST00000021004.1 ENSMUST00000021004.10 ENSMUST00000021004.11 ENSMUST00000021004.12 ENSMUST00000021004.13 ENSMUST00000021004.2 ENSMUST00000021004.3 ENSMUST00000021004.4 ENSMUST00000021004.5 ENSMUST00000021004.6 ENSMUST00000021004.7 ENSMUST00000021004.8 ENSMUST00000021004.9 NR_136915 Q925E0 SNTG2_MOUSE uc007ngr.1 uc007ngr.2 uc007ngr.3 uc007ngr.4 uc007ngr.5 Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB. Q925E0; P25100: ADRA1D; Xeno; NbExp=2; IntAct=EBI-8521556, EBI-489993; Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane. Belongs to the syntrophin family. actin binding structural molecule activity protein binding cytoplasm cytoskeleton plasma membrane dystrophin-associated glycoprotein complex membrane PDZ domain binding sarcolemma neuroligin family protein binding uc007ngr.1 uc007ngr.2 uc007ngr.3 uc007ngr.4 uc007ngr.5 
ENSMUST00000021005.15 Tpo ENSMUST00000021005.15 thyroid peroxidase (from RefSeq NM_009417.3) ENSMUST00000021005.1 ENSMUST00000021005.10 ENSMUST00000021005.11 ENSMUST00000021005.12 ENSMUST00000021005.13 ENSMUST00000021005.14 ENSMUST00000021005.2 ENSMUST00000021005.3 ENSMUST00000021005.4 ENSMUST00000021005.5 ENSMUST00000021005.6 ENSMUST00000021005.7 ENSMUST00000021005.8 ENSMUST00000021005.9 NM_009417 P35419 PERT_MOUSE Q8C8B1 uc007ngo.1 uc007ngo.2 uc007ngo.3 uc007ngo.4 This gene encodes a membrane-bound glycoprotein. The encoded enzyme plays a central role in thyroid gland function. The enzyme functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mice with homozygous missense mutations in this gene exhibit hypothyroid dwarfism and hearing impairment. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X60703.1, AK047843.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). Reaction=2 H(+) + H2O2 + 2 iodide = diiodine + 2 H2O; Xref=Rhea:RHEA:23336, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:16382, ChEBI:CHEBI:17606; EC=1.11.1.8; Evidence=; Reaction=[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O; Xref=Rhea:RHEA:48956, Rhea:RHEA-COMP:12274, Rhea:RHEA-COMP:12275, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:16382, ChEBI:CHEBI:46858, ChEBI:CHEBI:90870; EC=1.11.1.8; Evidence=; Reaction=[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O; Xref=Rhea:RHEA:48960, Rhea:RHEA-COMP:12275, Rhea:RHEA-COMP:12276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:16382, ChEBI:CHEBI:90870, ChEBI:CHEBI:90871; EC=1.11.1.8; Evidence=; Reaction=2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O; Xref=Rhea:RHEA:48964, Rhea:RHEA-COMP:12276, Rhea:RHEA-COMP:12277, Rhea:RHEA-COMP:12278, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:90871, ChEBI:CHEBI:90872, ChEBI:CHEBI:90873; EC=1.11.1.8; Evidence=; Reaction=[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3- iodo-L-tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O; Xref=Rhea:RHEA:48968, Rhea:RHEA-COMP:12275, Rhea:RHEA-COMP:12276, Rhea:RHEA-COMP:12278, Rhea:RHEA-COMP:12279, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:90870, ChEBI:CHEBI:90871, ChEBI:CHEBI:90873, ChEBI:CHEBI:90874; EC=1.11.1.8; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per heterodimer. Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer. ; Hormone biosynthesis; thyroid hormone biosynthesis. Interacts with DUOX1, DUOX2 and CYBA. Membrane ; Single-pass type I membrane protein Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface (By similarity). Cleaved in its N-terminal part. Belongs to the peroxidase family. XPO subfamily. iodide peroxidase activity peroxidase activity calcium ion binding extracellular space mitochondrion plasma membrane thyroid hormone generation response to oxidative stress cell surface membrane integral component of membrane oxidoreductase activity heme binding embryonic hemopoiesis hormone biosynthetic process hydrogen peroxide catabolic process metal ion binding oxidation-reduction process cellular oxidant detoxification uc007ngo.1 uc007ngo.2 uc007ngo.3 uc007ngo.4 
ENSMUST00000021011.3 Ccl7 ENSMUST00000021011.3 C-C motif chemokine ligand 7 (from RefSeq NM_013654.3) CCL7_MOUSE ENSMUST00000021011.1 ENSMUST00000021011.2 Fic Mcp3 NM_013654 Q03366 Scya7 uc007kmq.1 uc007kmq.2 uc007kmq.3 uc007kmq.4 Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity (By similarity). Monomer. Interacts with TNFAIP6 (via Link domain). Secreted. Belongs to the intercrine beta (chemokine CC) family. monocyte chemotaxis cytokine activity extracellular region extracellular space chemotaxis inflammatory response immune response cytoskeleton organization G-protein coupled receptor signaling pathway chemokine activity heparin binding regulation of cell shape response to gamma radiation positive regulation of cell migration neutrophil chemotaxis CCR1 chemokine receptor binding CCR2 chemokine receptor binding positive regulation of GTPase activity CCR chemokine receptor binding eosinophil chemotaxis lymphocyte chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to ethanol positive regulation of natural killer cell chemotaxis uc007kmq.1 uc007kmq.2 uc007kmq.3 uc007kmq.4 
ENSMUST00000021018.11 Taf15 ENSMUST00000021018.11 TATA-box binding protein associated factor 15 (from RefSeq NM_027427.3) ENSMUST00000021018.1 ENSMUST00000021018.10 ENSMUST00000021018.2 ENSMUST00000021018.3 ENSMUST00000021018.4 ENSMUST00000021018.5 ENSMUST00000021018.6 ENSMUST00000021018.7 ENSMUST00000021018.8 ENSMUST00000021018.9 NM_027427 Q8BQ46 Q8BQ46_MOUSE Taf15 uc007kpf.1 uc007kpf.2 uc007kpf.3 Nucleus Belongs to the RRM TET family. nucleic acid binding RNA binding mRNA 3'-UTR binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated RNA splicing gene expression metal ion binding mRNA stabilization uc007kpf.1 uc007kpf.2 uc007kpf.3 
ENSMUST00000021028.5 Itgb3 ENSMUST00000021028.5 integrin beta 3 (from RefSeq NM_016780.2) ENSMUST00000021028.1 ENSMUST00000021028.2 ENSMUST00000021028.3 ENSMUST00000021028.4 ITB3_MOUSE Itgb3 NM_016780 O54890 Q3TZC6 uc011ygd.1 uc011ygd.2 uc011ygd.3 uc011ygd.4 Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha- V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A- G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surfaces. Fibrinogen binding enhances SELP expression in activated platelets (PubMed:19332769). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (By similarity). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (By similarity). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). ITGAV:ITGB3 binds to the Lilrb4a/Gp49b receptor and enhances the Lilrb4a-mediated inhibition of mast cell activation (PubMed:11323698). ITGAV:ITGB3 also suppresses marginal zone B cell antibody production through its interaction with Lilrb4a (PubMed:24935931). In brain, plays a role in synaptic transmission and plasticity (PubMed:29038237, PubMed:18549786). Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin (PubMed:29038237). Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (PubMed:18549786). ITGAV:ITGB3 act as a receptor for CD40LG (By similarity). Heterodimer of an alpha and a beta subunit (By similarity). Beta-3 (ITGB3) associates with either alpha-IIB (ITGA2B) or alpha-V (ITGAV). Interacts with FLNB and COMP (By similarity). Interacts with PDIA6 following platelet stimulation (By similarity). Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion (By similarity). Interacts with MYO10 (By similarity). Interacts with DAB2 (PubMed:12606711). Interacts with FERMT2 (PubMed:18483218). Integrin ITGAV:ITGB3 interacts with FBLN5 (via N-terminus) (PubMed:11805835). Interacts with EMP2; regulates the levels of the heterodimer ITGA5:ITGB3 integrin expression on the plasma membrane (By similarity). ITGAV:ITGB3 interacts with CCN3 (By similarity). ITGAV:ITGB3 interacts with AGRA2 (By similarity). ITGAV:ITGB3 is found in a ternary complex with CX3CR1 and CX3CL1. ITGAV:ITGB3 is found in a ternary complex with NRG1 and ERBB3. ITGAV:ITGB3 is found in a ternary complex with FGF1 and FGFR1. ITGAV:ITGB3 interacts with FGF2; it is likely that FGF2 can simultaneously bind ITGAV:ITGB3 and FGF receptors (By similarity). ITGAV:ITGB3 binds to IL1B (By similarity). ITGAV:ITGB3 is found in a ternary complex with IGF1 and IGF1R (By similarity). ITGAV:ITGB3 interacts with IGF2 (By similarity). ITGAV:ITGB3 interacts with FBN1 (By similarity). ITGAV:ITGB3 interacts with CD9, CD81 and CD151 (via second extracellular domain) (By similarity). Interacts (via the allosteric site (site 2)) with CXCL12 in a CXCR4-independent manner (By similarity). Interacts with MXRA8/DICAM; the interaction inhibits ITGAV:ITGB3 heterodimer formation (PubMed:22492581). ITGAV:ITGB3 interacts with PTN. Forms a complex with PTPRZ1 and PTN that stimulates endothelial cell migration through ITGB3 Tyr-772 phosphorylation (By similarity). ITGAV:ITGB3 interacts with SLC6A4. Interacts with SLC6A4 (via C-terminus); this interaction regulates SLC6A4 trafficking (PubMed:29038237) (By similarity). ITGA2B:ITGB3 interacts with PPIA/CYPA; the interaction is ROS and PPIase activity-dependent and is increased in the presence of thrombin (PubMed:24429998). Interacts with tensin TNS3; TNS3 also interacts with PEAK1, thus acting as an adapter molecule to bridge the association of PEAK1 with ITGB3 (PubMed:35687021). Cell membrane ; Single-pass type I membrane protein Cell projection, lamellipodium membrane Cell junction, focal adhesion Postsynaptic cell membrane ; Single-pass type I membrane protein Synapse The VWFA domain (or beta I domain) contains three cation- binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site. Phosphorylated on tyrosine residues in response to thrombin- induced platelet aggregation. Probably involved in outside-in signaling. Animals are viable and fertile. Belongs to the integrin beta chain family. positive regulation of endothelial cell proliferation positive regulation of cell-matrix adhesion fibronectin binding protease binding positive regulation of leukocyte migration protein disulfide isomerase activity protein kinase C binding integrin binding protein binding nucleus plasma membrane cell-cell junction focal adhesion cell-substrate junction assembly cell adhesion cell-matrix adhesion integrin-mediated signaling pathway embryo implantation regulation of G-protein coupled receptor protein signaling pathway integrin complex response to radiation external side of plasma membrane cell surface positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of fibroblast migration negative regulation of lipid storage response to activity smooth muscle cell migration positive regulation of smooth muscle cell migration membrane integral component of membrane apical plasma membrane cell migration enzyme binding cell junction platelet activation regulation of cell migration positive regulation of cell migration lamellipodium membrane filopodium membrane microvillus membrane cell-substrate adhesion activation of protein kinase activity negative regulation of lipid transport ruffle membrane regulation of protein localization regulation of actin cytoskeleton organization macromolecular complex cell adhesion mediated by integrin positive regulation of cell adhesion mediated by integrin positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading integrin alpha9-beta1 complex integrin alphav-beta3 complex cellular response to drug alphav-beta3 integrin-PKCalpha complex alphav-beta3 integrin-IGF-1-IGF1R complex alphav-beta3 integrin-HMGB1 complex response to platelet-derived growth factor cellular response to platelet-derived growth factor stimulus apolipoprotein A-I-mediated signaling pathway melanosome identical protein binding cell projection vascular endothelial growth factor receptor 2 binding receptor complex apoptotic cell clearance synapse postsynaptic membrane positive regulation of osteoclast differentiation negative regulation of low-density lipoprotein particle receptor biosynthetic process positive regulation of angiogenesis positive regulation of bone resorption viral entry into host cell platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation positive regulation of smooth muscle cell proliferation cell projection morphogenesis positive regulation of peptidyl-tyrosine phosphorylation negative regulation of lipoprotein metabolic process cell adhesion molecule binding extracellular matrix binding negative chemotaxis regulation of release of sequestered calcium ion into cytosol regulation of serotonin uptake negative regulation of cell death regulation of protein tyrosine kinase activity fibrinogen binding positive regulation of ERK1 and ERK2 cascade platelet aggregation alpha9-beta1 integrin-ADAM8 complex cellular response to mechanical stimulus positive regulation of glomerular mesangial cell proliferation glutamatergic synapse positive regulation of substrate adhesion-dependent cell spreading positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway regulation of extracellular matrix organization cellular response to insulin-like growth factor stimulus positive regulation of T cell migration fibroblast growth factor binding C-X3-C chemokine binding insulin-like growth factor I binding neuregulin binding uc011ygd.1 uc011ygd.2 uc011ygd.3 uc011ygd.4 
ENSMUST00000021030.8 Mettl2 ENSMUST00000021030.8 methyltransferase 2, methylcytidine (from RefSeq NM_172567.3) D11Ertd768e ENSMUST00000021030.1 ENSMUST00000021030.2 ENSMUST00000021030.3 ENSMUST00000021030.4 ENSMUST00000021030.5 ENSMUST00000021030.6 ENSMUST00000021030.7 METL2_MOUSE Mettl2 NM_172567 Q3U5T7 Q5EBH8 Q8BMK1 Q8BXC2 uc007lxa.1 uc007lxa.2 uc007lxa.3 uc007lxa.4 S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767). N(3)-methylcytidine methylation by METTL2 requires the N6- threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (By similarity). Reaction=cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:50960, Rhea:RHEA-COMP:12850, Rhea:RHEA-COMP:12852, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74894, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50961; Evidence=; Reaction=cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60912, Rhea:RHEA-COMP:15710, Rhea:RHEA- COMP:15712, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74894, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60913; Evidence=; Monomer. Interacts with DALRD3. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BMK1-1; Sequence=Displayed; Name=2; IsoId=Q8BMK1-2; Sequence=VSP_008479; Mice were born with normal Mendelian ratio without developmental defects (PubMed:28655767). Cells show reduced N(3)-methylcytidine modification in tRNA fractions (PubMed:28655767). Belongs to the methyltransferase superfamily. METL family. tRNA C5-cytosine methylation cellular_component methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity transferase activity tRNA methylation methylation tRNA (cytosine-3-)-methyltransferase activity uc007lxa.1 uc007lxa.2 uc007lxa.3 uc007lxa.4 
ENSMUST00000021040.10 Cct6b ENSMUST00000021040.10 chaperonin containing TCP1 subunit 6B, transcript variant 1 (from RefSeq NM_009839.3) ENSMUST00000021040.1 ENSMUST00000021040.2 ENSMUST00000021040.3 ENSMUST00000021040.4 ENSMUST00000021040.5 ENSMUST00000021040.6 ENSMUST00000021040.7 ENSMUST00000021040.8 ENSMUST00000021040.9 NM_009839 Q61390 Q9R1U2 TCPW_MOUSE uc007kmx.1 uc007kmx.2 uc007kmx.3 uc007kmx.4 uc007kmx.5 Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Cytoplasm Testis specific. Belongs to the TCP-1 chaperonin family. nucleotide binding ATP binding cytoplasm cytosol chaperonin-containing T-complex protein folding unfolded protein binding toxin transport uc007kmx.1 uc007kmx.2 uc007kmx.3 uc007kmx.4 uc007kmx.5 
ENSMUST00000021044.4 5530401A14Rik ENSMUST00000021044.4 RIKEN cDNA 5530401A14 gene (from RefSeq NR_038010.1) ENSMUST00000021044.1 ENSMUST00000021044.2 ENSMUST00000021044.3 NR_038010 uc288atp.1 uc288atp.2 uc288atp.1 uc288atp.2 
ENSMUST00000021046.6 Ddx42 ENSMUST00000021046.6 DEAD box helicase 42, transcript variant 1 (from RefSeq NM_028074.4) DDX42_MOUSE ENSMUST00000021046.1 ENSMUST00000021046.2 ENSMUST00000021046.3 ENSMUST00000021046.4 ENSMUST00000021046.5 NM_028074 Q3TAN3 Q3TE60 Q810A7 Q8BWZ7 Q9D8Q2 uc007lyk.1 uc007lyk.2 uc007lyk.3 uc007lyk.4 ATP-dependent RNA helicase that binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Transient component of the SF3B subcomplex of the 17S U2 SnRNP complex. Interacts (via the C-terminus) with TP53BP2; the interaction is not inhibitied by TP53BP2 ubiquitination and is independent of p53/TP53. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q810A7-1; Sequence=Displayed; Name=2; IsoId=Q810A7-2; Sequence=VSP_023519; Belongs to the DEAD box helicase family. DDX42 subfamily. Sequence=AAH43036.4; Type=Erroneous initiation; Evidence=; nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus cytoplasm cytosol protein localization Cajal body nuclear speck hydrolase activity regulation of apoptotic process uc007lyk.1 uc007lyk.2 uc007lyk.3 uc007lyk.4 
ENSMUST00000021048.7 Ftsj3 ENSMUST00000021048.7 FtsJ RNA 2'-O-methyltransferase 3 (from RefSeq NM_025310.3) ENSMUST00000021048.1 ENSMUST00000021048.2 ENSMUST00000021048.3 ENSMUST00000021048.4 ENSMUST00000021048.5 ENSMUST00000021048.6 NM_025310 Q3ULI1 Q921I7 Q9DBE9 SPB1_MOUSE uc007lym.1 uc007lym.2 uc007lym.3 RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Reaction=a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O- methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48628, Rhea:RHEA-COMP:12164, Rhea:RHEA-COMP:12165, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90675, ChEBI:CHEBI:90676; Evidence= Interacts with NIP7. Nucleus, nucleolus Citrullinated by PADI4. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. enzyme-directed rRNA 2'-O-methylation maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA methylation nucleus nucleolus rRNA processing methyltransferase activity rRNA methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (guanine) methyltransferase activity transferase activity preribosome, large subunit precursor preribosome, small subunit precursor rRNA methylation methylation ribosome biogenesis uc007lym.1 uc007lym.2 uc007lym.3 
ENSMUST00000021049.9 Psmc5 ENSMUST00000021049.9 protease (prosome, macropain) 26S subunit, ATPase 5 (from RefSeq NM_008950.1) ENSMUST00000021049.1 ENSMUST00000021049.2 ENSMUST00000021049.3 ENSMUST00000021049.4 ENSMUST00000021049.5 ENSMUST00000021049.6 ENSMUST00000021049.7 ENSMUST00000021049.8 NM_008950 O35051 P47210 P52915 P52916 P62196 PRS8_MOUSE Q3UL51 Q9CWN5 Sug1 uc007lyn.1 uc007lyn.2 uc007lyn.3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (By similarity). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC5 and few additional components (By similarity). Component of a complex with USP49 and RUVBL1 (By similarity). Interacts with PRPF19 (PubMed:17349974). Interacts with TRIM5 (By similarity). Interacts with NDC80 (By similarity). Interacts with PAAF1 (By similarity). Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR) (PubMed:8598193). Interacts with ERCC6 (By similarity). P62196; P19447: ERCC3; Xeno; NbExp=6; IntAct=EBI-357713, EBI-1183307; Cytoplasm Nucleus Belongs to the AAA ATPase family. nucleotide binding proteasome complex receptor binding protein binding ATP binding nucleus holo TFIIH complex cytoplasm proteasome regulatory particle regulation of transcription from RNA polymerase II promoter transcription factor binding proteasome regulatory particle, base subcomplex inclusion body hydrolase activity ATPase activity TBP-class protein binding proteasome accessory complex protein catabolic process cytoplasmic vesicle thyrotropin-releasing hormone receptor binding nuclear proteasome complex cytosolic proteasome complex proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of transcription, DNA-templated positive regulation of RNA polymerase II transcriptional preinitiation complex assembly modulation of synaptic transmission positive regulation of inclusion body assembly postsynapse uc007lyn.1 uc007lyn.2 uc007lyn.3 
ENSMUST00000021050.14 Adap2 ENSMUST00000021050.14 ArfGAP with dual PH domains 2 (from RefSeq NM_172133.1) ADAP2_MOUSE Centa2 ENSMUST00000021050.1 ENSMUST00000021050.10 ENSMUST00000021050.11 ENSMUST00000021050.12 ENSMUST00000021050.13 ENSMUST00000021050.2 ENSMUST00000021050.3 ENSMUST00000021050.4 ENSMUST00000021050.5 ENSMUST00000021050.6 ENSMUST00000021050.7 ENSMUST00000021050.8 ENSMUST00000021050.9 NM_172133 Q8R2V5 uc007klk.1 uc007klk.2 uc007klk.3 GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity). Cytoplasm Cell membrane Note=Constitutively associated with the plasma membrane. Excluded from the nucleus (By similarity). GTPase activator activity 1-phosphatidylinositol binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm mitochondrial envelope plasma membrane heart development membrane phosphatidylinositol-3,4-bisphosphate binding inositol 1,3,4,5 tetrakisphosphate binding positive regulation of GTPase activity metal ion binding inositol lipid-mediated signaling phosphatidylinositol bisphosphate binding uc007klk.1 uc007klk.2 uc007klk.3 
ENSMUST00000021052.16 Smarcd2 ENSMUST00000021052.16 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2, transcript variant 1 (from RefSeq NM_001130187.1) B1ARI7 B1ARJ6 Baf60b ENSMUST00000021052.1 ENSMUST00000021052.10 ENSMUST00000021052.11 ENSMUST00000021052.12 ENSMUST00000021052.13 ENSMUST00000021052.14 ENSMUST00000021052.15 ENSMUST00000021052.2 ENSMUST00000021052.3 ENSMUST00000021052.4 ENSMUST00000021052.5 ENSMUST00000021052.6 ENSMUST00000021052.7 ENSMUST00000021052.8 ENSMUST00000021052.9 NM_001130187 Q99JR8 SMRD2_MOUSE uc007lyp.1 uc007lyp.2 uc007lyp.3 uc007lyp.4 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation. Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B), and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (ACTB). Interacts with UNKL. Interacts with CEBPE. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99JR8-1; Sequence=Displayed; Name=2; IsoId=Q99JR8-2; Sequence=VSP_040533; Ubiquitinated through a signaling process involving RAC1 and the RING finger protein UNKL. Belongs to the SMARCD family. Sequence=AAH05732.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleus nucleoplasm chromatin organization nucleosome disassembly chromatin remodeling SWI/SNF complex ATP-dependent chromatin remodeling uc007lyp.1 uc007lyp.2 uc007lyp.3 uc007lyp.4 
ENSMUST00000021056.8 Scn4a ENSMUST00000021056.8 sodium channel, voltage-gated, type IV, alpha, transcript variant 1 (from RefSeq NM_133199.3) ENSMUST00000021056.1 ENSMUST00000021056.2 ENSMUST00000021056.3 ENSMUST00000021056.4 ENSMUST00000021056.5 ENSMUST00000021056.6 ENSMUST00000021056.7 G3X8T7 G3X8T7_MOUSE NM_133199 Scn4a uc007lyu.1 uc007lyu.2 uc007lyu.3 Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. voltage-gated sodium channel complex ion channel activity voltage-gated ion channel activity voltage-gated sodium channel activity sodium channel activity plasma membrane integral component of plasma membrane ion transport sodium ion transport membrane integral component of membrane regulation of ion transmembrane transport sodium ion transmembrane transport transmembrane transport regulation of skeletal muscle contraction by action potential uc007lyu.1 uc007lyu.2 uc007lyu.3 
ENSMUST00000021060.6 Polg2 ENSMUST00000021060.6 polymerase (DNA directed), gamma 2, accessory subunit, transcript variant 2 (from RefSeq NR_027785.2) B1ARB5 DPOG2_MOUSE ENSMUST00000021060.1 ENSMUST00000021060.2 ENSMUST00000021060.3 ENSMUST00000021060.4 ENSMUST00000021060.5 Mtpolb NR_027785 O35614 Q9QZM2 uc007lzm.1 uc007lzm.2 uc007lzm.3 uc007lzm.4 Mitochondrial polymerase processivity subunit. It regulates the polymerase and exonuclease activities promoting processive DNA synthesis. Binds to ss-DNA. Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits. Q9QZM2; Q9QZM2: Polg2; NbExp=2; IntAct=EBI-853043, EBI-853043; Mitochondrion. in utero embryonic development DNA binding DNA-directed DNA polymerase activity cytoplasm mitochondrion DNA replication mitochondrial DNA replication DNA repair transferase activity nucleotidyltransferase activity respiratory electron transport chain mitochondrial DNA metabolic process mitochondrial nucleoid identical protein binding mitochondrion morphogenesis DNA biosynthetic process uc007lzm.1 uc007lzm.2 uc007lzm.3 uc007lzm.4 
ENSMUST00000021062.12 Ddx5 ENSMUST00000021062.12 DEAD box helicase 5 (from RefSeq NM_007840.3) Ddx5 ENSMUST00000021062.1 ENSMUST00000021062.10 ENSMUST00000021062.11 ENSMUST00000021062.2 ENSMUST00000021062.3 ENSMUST00000021062.4 ENSMUST00000021062.5 ENSMUST00000021062.6 ENSMUST00000021062.7 ENSMUST00000021062.8 ENSMUST00000021062.9 NM_007840 Q6P5F8 Q8BTS0 Q8BTS0_MOUSE uc007lzq.1 uc007lzq.2 uc007lzq.3 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Belongs to the DEAD box helicase family. negative regulation of transcription from RNA polymerase II promoter nucleotide binding alternative mRNA splicing, via spliceosome regulation of alternative mRNA splicing, via spliceosome nuclear-transcribed mRNA catabolic process epithelial to mesenchymal transition nucleic acid binding RNA helicase activity mRNA 3'-UTR binding helicase activity calmodulin binding ATP binding nucleus nucleolus regulation of transcription from RNA polymerase II promoter mRNA transcription hydrolase activity enzyme binding BMP signaling pathway intracellular estrogen receptor signaling pathway androgen receptor signaling pathway MH2 domain binding pre-mRNA binding ribonucleoprotein complex binding positive regulation of DNA damage response, signal transduction by p53 class mediator regulation of viral genome replication SMAD binding calcium-dependent protein binding androgen receptor binding regulation of androgen receptor signaling pathway R-SMAD binding primary miRNA binding catalytic step 2 spliceosome intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of production of miRNAs involved in gene silencing by miRNA ribonucleoprotein complex uc007lzq.1 uc007lzq.2 uc007lzq.3 
ENSMUST00000021063.13 Psmd12 ENSMUST00000021063.13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 (from RefSeq NM_025894.2) ENSMUST00000021063.1 ENSMUST00000021063.10 ENSMUST00000021063.11 ENSMUST00000021063.12 ENSMUST00000021063.2 ENSMUST00000021063.3 ENSMUST00000021063.4 ENSMUST00000021063.5 ENSMUST00000021063.6 ENSMUST00000021063.7 ENSMUST00000021063.8 ENSMUST00000021063.9 NM_025894 PSD12_MOUSE Q9CQT4 Q9CYB3 Q9D8W5 uc007mar.1 uc007mar.2 uc007mar.3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the 19S proteasome regulatory particle complex (PubMed:16857966). The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (By similarity). The regulatory particle is made of a lid composed of 9 subunits including PSMD12, a base containing 6 ATPases and few additional components (By similarity). Interacts with ERCC6 (By similarity). Belongs to the proteasome subunit p55 family. proteasome complex molecular_function cytoplasm proteasome regulatory particle proteasome regulatory particle, lid subcomplex proteasome accessory complex nuclear proteasome complex proteasome-mediated ubiquitin-dependent protein catabolic process uc007mar.1 uc007mar.2 uc007mar.3 
ENSMUST00000021065.6 Cacng1 ENSMUST00000021065.6 calcium channel, voltage-dependent, gamma subunit 1 (from RefSeq NM_007582.2) Cacng1 ENSMUST00000021065.1 ENSMUST00000021065.2 ENSMUST00000021065.3 ENSMUST00000021065.4 ENSMUST00000021065.5 NM_007582 Q4KL26 Q4KL26_MOUSE uc007may.1 uc007may.2 uc007may.3 Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. Component of a calcium channel complex consisting of a pore- forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2. Cell membrane, sarcolemma ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity voltage-gated calcium channel complex ion transport calcium ion transport membrane integral component of membrane regulation of ion transmembrane transport calcium ion transmembrane transport uc007may.1 uc007may.2 uc007may.3 
ENSMUST00000021066.4 Cacng4 ENSMUST00000021066.4 calcium channel, voltage-dependent, gamma subunit 4 (from RefSeq NM_019431.4) CCG4_MOUSE ENSMUST00000021066.1 ENSMUST00000021066.2 ENSMUST00000021066.3 NM_019431 Q9JJV4 uc007maz.1 uc007maz.2 uc007maz.3 Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:17880894). Interacts with CACNA1C. Identified in a complex with the L- type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or CACNB2 (By similarity). Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Interacts with GRIA1 (By similarity). Cell membrane ; Multi-pass membrane protein Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel regulator activity calcium channel activity plasma membrane voltage-gated calcium channel complex ion transport calcium ion transport cell surface postsynaptic density membrane integral component of membrane transmission of nerve impulse AMPA glutamate receptor complex regulation of ion transmembrane transport ionotropic glutamate receptor binding somatodendritic compartment response to cocaine cell body calcium ion transmembrane transport postsynaptic density membrane neurotransmitter receptor transport, postsynaptic endosome to lysosome regulation of postsynaptic neurotransmitter receptor activity postsynaptic neurotransmitter receptor diffusion trapping glutamatergic synapse integral component of postsynaptic density membrane neurotransmitter receptor internalization L-type voltage-gated calcium channel complex regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc007maz.1 uc007maz.2 uc007maz.3 
ENSMUST00000021076.6 Rab37 ENSMUST00000021076.6 RAB37, member RAS oncogene family, transcript variant 1 (from RefSeq NM_021411.4) ENSMUST00000021076.1 ENSMUST00000021076.2 ENSMUST00000021076.3 ENSMUST00000021076.4 ENSMUST00000021076.5 NM_021411 Q544E8 Q544E8_MOUSE Rab37 uc007mgo.1 uc007mgo.2 uc007mgo.3 uc007mgo.4 Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding endoplasmic reticulum-Golgi intermediate compartment uc007mgo.1 uc007mgo.2 uc007mgo.3 uc007mgo.4 
ENSMUST00000021077.4 Nherf1 ENSMUST00000021077.4 NHERF family PDZ scaffold protein 1 (from RefSeq NM_012030.2) ENSMUST00000021077.1 ENSMUST00000021077.2 ENSMUST00000021077.3 NM_012030 Nherf1 Q3TG37 Q3TG37_MOUSE Slc9a3r1 uc007mgp.1 uc007mgp.2 uc007mgp.3 Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Cell membrane Cell projection, filopodium Cell projection, microvillus Cell projection, ruffle Endomembrane system ; Peripheral membrane protein receptor binding cytoplasm plasma membrane microvillus nuclear migration beta-catenin binding negative regulation of cell proliferation regulation of cell shape regulation of cell size endomembrane system membrane apical plasma membrane chloride channel regulator activity phosphatase binding protein domain specific binding gland morphogenesis microvillus assembly PDZ domain binding microvillus membrane beta-2 adrenergic receptor binding positive regulation of ion transmembrane transport protein self-association macromolecular complex binding membrane raft myosin II binding establishment of epithelial cell apical/basal polarity negative regulation of mitotic cell cycle protein N-terminus binding perinuclear region of cytoplasm establishment of Golgi localization negative regulation of protein kinase B signaling binding, bridging negative regulation of ERK1 and ERK2 cascade growth factor receptor binding cell periphery protein localization to plasma membrane negative regulation of canonical Wnt signaling pathway renal phosphate ion absorption positive regulation of intrinsic apoptotic signaling pathway uc007mgp.1 uc007mgp.2 uc007mgp.3 
ENSMUST00000021078.3 Fdxr ENSMUST00000021078.3 ferredoxin reductase (from RefSeq NM_007997.1) ADRO_MOUSE ENSMUST00000021078.1 ENSMUST00000021078.2 NM_007997 Q61578 uc007mgy.1 uc007mgy.2 uc007mgy.3 Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C- 27 hydroxylation in the liver. Reaction=H(+) + NADP(+) + 2 reduced [adrenodoxin] = NADPH + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:42312, Rhea:RHEA-COMP:9998, Rhea:RHEA- COMP:9999, ChEBI:CHEBI:15378, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.18.1.6; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Steroid metabolism; cholesterol metabolism. Monomer. Interacts directly with FDX1. Mitochondrion inner membrane ; Peripheral membrane protein Expressed in the adrenal, testis and ovary and to a lesser extent in the liver and kidney. Belongs to the ferredoxin--NADP reductase type 1 family. mitochondrion mitochondrial inner membrane lipid metabolic process ubiquinone biosynthetic process steroid metabolic process cholesterol metabolic process NADPH-adrenodoxin reductase activity membrane oxidoreductase activity oxidation-reduction process NADPH binding NADPH oxidation uc007mgy.1 uc007mgy.2 uc007mgy.3 
ENSMUST00000021082.7 Nt5c ENSMUST00000021082.7 5',3'-nucleotidase, cytosolic, transcript variant 5 (from RefSeq NR_184550.1) Dnt1 ENSMUST00000021082.1 ENSMUST00000021082.2 ENSMUST00000021082.3 ENSMUST00000021082.4 ENSMUST00000021082.5 ENSMUST00000021082.6 NR_184550 NT5C_MOUSE Q9JM14 uc007mhu.1 uc007mhu.2 uc007mhu.3 uc007mhu.4 Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Kinetic parameters: KM=0.42 mM for dUMP-5' ; KM=1.25 mM for dTMP-5' ; KM=1.2 mM for dGMP-5' ; KM=1.0 mM for dAMP-5' ; KM=3.6 mM for dCMP-5' ; KM=0.4 mM for UMP-3 ; Homodimer. Cytoplasm Belongs to the 5'(3')-deoxyribonucleotidase family. nucleotide binding nucleus cytoplasm mitochondrion cytosol nucleotidase activity 5'-nucleotidase activity nucleotide metabolic process pyrimidine deoxyribonucleotide catabolic process deoxyribonucleotide catabolic process dephosphorylation hydrolase activity phosphatase activity pyrimidine nucleotide binding metal ion binding uc007mhu.1 uc007mhu.2 uc007mhu.3 uc007mhu.4 
ENSMUST00000021083.7 Jpt1 ENSMUST00000021083.7 Jupiter microtubule associated homolog 1 (from RefSeq NM_008258.2) ENSMUST00000021083.1 ENSMUST00000021083.2 ENSMUST00000021083.3 ENSMUST00000021083.4 ENSMUST00000021083.5 ENSMUST00000021083.6 Hn1 JUPI1_MOUSE Jpt1 NM_008258 P97825 uc007mhv.1 uc007mhv.2 uc007mhv.3 Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (By similarity). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (By similarity). Interacts with the complex composed, at least, of APC, CTNNB1 and GSK3B; the interaction takes place with the inactive form of GSK3B (phosphorylated at 'Ser-9'). Nucleus Cytoplasm Expressed in yolk sac, fetal brain, brain, spleen and bone marrow. Negatively regulated by the microRNA miR-132. Belongs to the JUPITER family. molecular_function nucleus nucleolus cytoplasm biological_process nuclear membrane uc007mhv.1 uc007mhv.2 uc007mhv.3 
ENSMUST00000021085.11 Nup85 ENSMUST00000021085.11 nucleoporin 85 (from RefSeq NM_001002929.4) A2A9W9 A2A9X0 ENSMUST00000021085.1 ENSMUST00000021085.10 ENSMUST00000021085.2 ENSMUST00000021085.3 ENSMUST00000021085.4 ENSMUST00000021085.5 ENSMUST00000021085.6 ENSMUST00000021085.7 ENSMUST00000021085.8 ENSMUST00000021085.9 NM_001002929 NUP85_MOUSE Pcnt1 Q8R480 Q9CYI9 uc007mhx.1 uc007mhx.2 uc007mhx.3 uc007mhx.4 Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade. Involved in nephrogenesis. Component of the nuclear pore complex (NPC). Component of the NPC Nup107-160 subcomplex, consisting of at least NUP107, NUP98/Nup96, NUP160, NUP133, NUP85, NUP37, NUP43 and SEC13. Interacts with NUP160, NUP133 and SEC13 (PubMed:12718872). Interacts with NUP37, NUP107 and NUP43. Interacts with CCR2. Nucleus, nuclear pore complex Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Cytoplasm Nucleus membrane Note=During mitosis, localizes to the kinetochores and spindle poles. Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells. Belongs to the nucleoporin Nup85 family. Sequence=CAM23011.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM23012.1; Type=Erroneous gene model prediction; Evidence=; chromosome, centromeric region kinetochore condensed chromosome kinetochore nucleus nuclear pore chromosome cytoplasm spindle cytosol cytoskeleton plasma membrane mRNA export from nucleus protein import into nucleus chemotaxis protein transport membrane structural constituent of nuclear pore cytokine-mediated signaling pathway lamellipodium assembly nuclear pore outer ring CCR2 chemokine receptor binding nuclear membrane positive regulation of transcription, DNA-templated macrophage chemotaxis mRNA transport nephron development uc007mhx.1 uc007mhx.2 uc007mhx.3 uc007mhx.4 
ENSMUST00000021087.14 Mif4gd ENSMUST00000021087.14 MIF4G domain containing, transcript variant 2 (from RefSeq NM_001243584.1) ENSMUST00000021087.1 ENSMUST00000021087.10 ENSMUST00000021087.11 ENSMUST00000021087.12 ENSMUST00000021087.13 ENSMUST00000021087.2 ENSMUST00000021087.3 ENSMUST00000021087.4 ENSMUST00000021087.5 ENSMUST00000021087.6 ENSMUST00000021087.7 ENSMUST00000021087.8 ENSMUST00000021087.9 MI4GD_MOUSE NM_001243584 Q05CE9 Q3UBZ5 Q7TMH3 Q8R333 uc007mid.1 uc007mid.2 uc007mid.3 uc007mid.4 uc007mid.5 Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity). Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also interacts with EIF4G1 which is bound to their 5'-end. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UBZ5-1; Sequence=Displayed; Name=2; IsoId=Q3UBZ5-2; Sequence=VSP_033878, VSP_033879; Belongs to the MIF4GD family. RNA binding nucleus nucleolus cytoplasm cytosol regulation of translation regulation of translational initiation protein C-terminus binding translation activator activity identical protein binding positive regulation of translation uc007mid.1 uc007mid.2 uc007mid.3 uc007mid.4 uc007mid.5 
ENSMUST00000021090.14 Grb2 ENSMUST00000021090.14 growth factor receptor bound protein 2, transcript variant 1 (from RefSeq NM_008163.4) ENSMUST00000021090.1 ENSMUST00000021090.10 ENSMUST00000021090.11 ENSMUST00000021090.12 ENSMUST00000021090.13 ENSMUST00000021090.2 ENSMUST00000021090.3 ENSMUST00000021090.4 ENSMUST00000021090.5 ENSMUST00000021090.6 ENSMUST00000021090.7 ENSMUST00000021090.8 ENSMUST00000021090.9 GRB2_MOUSE NM_008163 Q60631 Q61240 uc007mik.1 uc007mik.2 uc007mik.3 The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]. Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. Associates (via SH2 domain) with activated EGF and PDGF receptors (tyrosine phosphorylated) (By similarity). Interacts with PDGFRA (tyrosine phosphorylated); the interaction may be indirect (PubMed:8943348). Interacts with IRS4 (when Tyr-phosphorylated) (PubMed:11113178). Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains (By similarity). It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Interacts with SOS1 (By similarity). Forms a complex with MUC1 and SOS1, through interaction of the SH3 domains with SOS1 and the SH2 domain with phosphorylated MUC1 (By similarity). Interacts with phosphorylated MET (By similarity). Interacts with phosphorylated TOM1L1 (PubMed:11711534). Interacts with the phosphorylated C-terminus of SH2B2 (By similarity). Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation (By similarity) (PubMed:16249387, PubMed:14610044, PubMed:15477350, PubMed:15477348, PubMed:22561606). Interacts with NISCH, PTPNS1 and REPS2 (By similarity). Interacts with syntrophin SNTA1 (PubMed:11551227). Interacts (via SH3 domains) with REPS1 (PubMed:9395447). Interacts (via SH3 domains) with PIK3C2B (By similarity). Interacts with CBL and CBLB (By similarity). Interacts with AJUBA and CLNK (PubMed:10330178, PubMed:11463797). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (PubMed:10521483). Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2 (By similarity). Interacts with PTPN11 (PubMed:8943348). Interacts with PRNP (PubMed:11571277). Interacts with RALGPS1 (By similarity). Interacts also with HCST (PubMed:16582911). Interacts with KDR (PubMed:16966330). Interacts with FLT1 (tyrosine- phosphorylated) (PubMed:9722576). Interacts with GAPT and PTPRE (By similarity). Interacts (via SH2 domain) with KIF26A (By similarity). Interacts (via SH3 2) with GAB2 (PubMed:10068651). Interacts with ADAM15 (By similarity). Interacts with THEMIS2 (PubMed:20644716). Interacts (via SH2 domain) with AXL (phosphorylated) (By similarity). Interacts (via SH2 domain) with KIT (phosphorylated) (PubMed:10377264). Interacts with PTPRJ and BCR (By similarity). Interacts with PTPN23 (By similarity). Interacts with FLT4 (tyrosine phosphorylated) (By similarity). Interacts with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate cell migration (PubMed:12925710). Part of a complex including TNK2, GRB2 and one receptor tyrosine kinase (RTK) such as AXL and PDGFRL, in which GRB2 promotes RTK recruitment by TNK2 (By similarity). Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (PubMed:9312046). Interacts with ERBB4 (By similarity). Interacts with NTRK1 (phosphorylated upon ligand-binding) (By similarity). Interacts with PTK2/FAK1 (tyrosine phosphorylated) (PubMed:7997267). Interacts with PTK2B/PYK2 (tyrosine phosphorylated) (By similarity). Interacts (via SH2-domain) with SCIMP; this interaction is dependent on phosphorylation of SCIMP 'Tyr-58' (PubMed:21930792, PubMed:28098138, PubMed:28290451). Interacts (via SH3 domains) with GAREM1 (via proline-rich domain and tyrosine phosphorylated); the interaction occurs upon EGF stimulation (By similarity). Interacts with DAB2 (PubMed:9569023). Interacts with TESPA1 (By similarity). Interacts with THEMIS (PubMed:19597498, PubMed:19597497, PubMed:19805304, PubMed:22561606). Interacts with PLCG1, LAT and THEMIS upon TCR activation in thymocytes; the association is weaker in the absence of TESPA1 (PubMed:22561606). Interacts with CD28 (By similarity). Interacts with RAB13; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA (PubMed:21543326). Interacts with ASAP3 (phosphorylated form) (By similarity). Interacts (via SH2 domain) with PTPRH (phosphorylated form) (PubMed:20398064). Interacts with PTPRO (phosphorylated form) (PubMed:20398064). Interacts with PTPRB (phosphorylated form) (PubMed:20398064). Interacts (via SH3 domain 2) with PRR14 (via proline-rich region) (By similarity). Interacts with DENND2B (By similarity). Interacts with SPRY2 (By similarity). Interacts with LRRC8A (PubMed:32930093). Interacts with PEAK1 (By similarity). Q60631; O54737: Blnk; NbExp=4; IntAct=EBI-1688, EBI-641814; Q60631; P35991: Btk; NbExp=4; IntAct=EBI-1688, EBI-625119; Q60631; B9EKI5: Cblb; NbExp=3; IntAct=EBI-1688, EBI-682463; Q60631; P35329: Cd22; NbExp=4; IntAct=EBI-1688, EBI-300059; Q60631; P98078: Dab2; NbExp=4; IntAct=EBI-1688, EBI-1391846; Q60631; Q99JZ7: Errfi1; NbExp=3; IntAct=EBI-1688, EBI-643375; Q60631; Q8C180: Frs2; NbExp=5; IntAct=EBI-1688, EBI-6880000; Q60631; Q9QYY0: Gab1; NbExp=8; IntAct=EBI-1688, EBI-644784; Q60631; Q60749: Khdrbs1; NbExp=2; IntAct=EBI-1688, EBI-519077; Q60631; Q52KG5: Kif26a; NbExp=2; IntAct=EBI-1688, EBI-2480646; Q60631; O54957: Lat; NbExp=5; IntAct=EBI-1688, EBI-6390034; Q60631; Q62077: Plcg1; NbExp=2; IntAct=EBI-1688, EBI-300133; Q60631; P04925: Prnp; NbExp=7; IntAct=EBI-1688, EBI-768613; Q60631; P35235: Ptpn11; NbExp=3; IntAct=EBI-1688, EBI-397236; Q60631; P18052: Ptpra; NbExp=4; IntAct=EBI-1688, EBI-6597520; Q60631; Q91ZZ2: Rapgef1; NbExp=3; IntAct=EBI-1688, EBI-644719; Q60631; P98083: Shc1; NbExp=8; IntAct=EBI-1688, EBI-300201; Q60631; Q61234: Snta1; NbExp=3; IntAct=EBI-1688, EBI-295952; Q60631; Q62245: Sos1; NbExp=7; IntAct=EBI-1688, EBI-1693; Q60631; Q02384: Sos2; NbExp=5; IntAct=EBI-1688, EBI-395573; Q60631; Q02858: Tek; NbExp=3; IntAct=EBI-1688, EBI-7099626; Q60631; Q99PM9: Uck2; NbExp=3; IntAct=EBI-1688, EBI-644712; Q60631-1; Q8BGW0-1: Themis; NbExp=3; IntAct=EBI-15532571, EBI-15806957; Nucleus Cytoplasm Endosome Golgi apparatus Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q60631-1; Sequence=Displayed; Name=2; Synonyms=GRB3-3; IsoId=Q60631-2; Sequence=VSP_001841; Expressed in macrophages. The SH3 domains mediate interaction with RALGPS1 and SHB. Belongs to the GRB2/sem-5/DRK family. Name=Wikipedia; Note=Grb2 entry; URL="https://en.wikipedia.org/wiki/Grb2"; phosphotyrosine binding SH3/SH2 adaptor activity epidermal growth factor receptor binding neurotrophin TRKA receptor binding protein binding nucleus nucleoplasm nucleolus cytoplasm endosome Golgi apparatus cytosol plasma membrane cell-cell junction Ras protein signal transduction aging COP9 signalosome insulin receptor signaling pathway positive regulation of signal transduction vesicle membrane membrane SH3 domain binding enzyme binding protein kinase binding protein phosphatase binding protein domain specific binding cell differentiation positive regulation of actin filament polymerization receptor internalization macromolecular complex signal transduction in response to DNA damage identical protein binding regulation of MAPK cascade insulin receptor substrate binding ephrin receptor binding anatomical structure formation involved in morphogenesis phosphoprotein binding protein heterooligomerization branching involved in labyrinthine layer morphogenesis Grb2-EGFR complex cellular response to ionizing radiation positive regulation of reactive oxygen species metabolic process uc007mik.1 uc007mik.2 uc007mik.3 
ENSMUST00000021091.15 Pafah1b1 ENSMUST00000021091.15 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1, transcript variant 1 (from RefSeq NM_013625.4) ENSMUST00000021091.1 ENSMUST00000021091.10 ENSMUST00000021091.11 ENSMUST00000021091.12 ENSMUST00000021091.13 ENSMUST00000021091.14 ENSMUST00000021091.2 ENSMUST00000021091.3 ENSMUST00000021091.4 ENSMUST00000021091.5 ENSMUST00000021091.6 ENSMUST00000021091.7 ENSMUST00000021091.8 ENSMUST00000021091.9 LIS1 NM_013625 PAFAH1B1 Pafah1b1 Q5SW18 Q5SW18_MOUSE uc011xyy.1 uc011xyy.2 uc011xyy.3 Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position. Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Cytoplasm, cytoskeleton toplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Nucleus membrane Note=Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes. Dimerization mediated by the LisH domain may be required to activate dynein. Belongs to the WD repeat LIS1/nudF family. establishment of mitotic spindle orientation astral microtubule kinetochore neuron migration nucleus nuclear envelope cytoplasm centrosome microtubule organizing center spindle cytosol cytoskeleton kinesin complex microtubule microtubule associated complex cell cortex lipid metabolic process microtubule-based process cell cycle nuclear migration multicellular organism development nervous system development brain development adult locomotory behavior negative regulation of neuron projection development membrane lipid catabolic process stem cell division corpus callosum morphogenesis cerebral cortex neuron differentiation cerebral cortex development cell differentiation axon growth cone microtubule organizing center organization nuclear membrane vesicle neuron projection neuronal cell body macromolecular complex binding dynein intermediate chain binding positive regulation of axon extension positive regulation of mitotic cell cycle brain morphogenesis neuromuscular process controlling balance microtubule sliding cell division establishment of centrosome localization dynein complex binding central region of growth cone uc011xyy.1 uc011xyy.2 uc011xyy.3 
ENSMUST00000021097.10 Recql5 ENSMUST00000021097.10 RecQ protein-like 5 (from RefSeq NM_130454.2) ENSMUST00000021097.1 ENSMUST00000021097.2 ENSMUST00000021097.3 ENSMUST00000021097.4 ENSMUST00000021097.5 ENSMUST00000021097.6 ENSMUST00000021097.7 ENSMUST00000021097.8 ENSMUST00000021097.9 NM_130454 Q8BQD7 Q8C7T6 Q8VID3 Q8VID5 RECQ5_MOUSE uc007mix.1 uc007mix.2 uc007mix.3 uc007mix.4 DNA helicase that plays an important role in DNA replication, transcription and repair. Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability. Associates also with POLR1A and enforces the stability of ribosomal DNA arrays. Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress. Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Monomer. Interacts with TOP2A, TOP3A and TOP3B. Interacts with RNA polymerase II subunit POLR2A. Identified in a complex with the RNA polymerase II core bound to DNA. Interacts with RAD51 (By similarity). Interacts with WRN; this interaction stimulates WRN helicase activity on DNA fork duplexes (By similarity). Interacts with MUS1; this interaction promotes MUS81-dependent mitotic DNA synthesis (By similarity). Nucleus, nucleoplasm Note=Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks. Phosphorylated by CDK1 at Ser-728; this phosphorylation is required for RECQL5-mediated disruption of RAD51 filaments on stalled replication forks. Belongs to the helicase family. RecQ subfamily. nucleotide binding mitotic cell cycle double-strand break repair via homologous recombination RNA polymerase II core binding nucleic acid binding DNA helicase activity helicase activity ATP binding nucleus nucleoplasm chromosome cytoplasm cytosol DNA replication DNA unwinding involved in DNA replication DNA repair DNA recombination cellular response to DNA damage stimulus cell cycle four-way junction helicase activity DNA-directed RNA polymerase II, holoenzyme hydrolase activity DNA duplex unwinding negative regulation of transcription elongation from RNA polymerase II promoter cellular response to drug identical protein binding cell division chromosome separation cellular response to camptothecin replication-born double-strand break repair via sister chromatid exchange negative regulation of double-strand break repair via homologous recombination uc007mix.1 uc007mix.2 uc007mix.3 uc007mix.4 
ENSMUST00000021114.5 Galk1 ENSMUST00000021114.5 galactokinase 1 (from RefSeq NM_016905.2) ENSMUST00000021114.1 ENSMUST00000021114.2 ENSMUST00000021114.3 ENSMUST00000021114.4 GALK1_MOUSE Galk Glk NM_016905 Q9JIA6 Q9R0N0 uc007mjn.1 uc007mjn.2 uc007mjn.3 Catalyzes the transfer of a phosphate from ATP to alpha-D- galactose and participates in the first committed step in the catabolism of galactose. Reaction=alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+); Xref=Rhea:RHEA:13553, ChEBI:CHEBI:15378, ChEBI:CHEBI:28061, ChEBI:CHEBI:30616, ChEBI:CHEBI:58336, ChEBI:CHEBI:456216; EC=2.7.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13554; Evidence=; Carbohydrate metabolism; galactose metabolism. Homodimer. Belongs to the GHMP kinase family. GalK subfamily. nucleotide binding galactokinase activity protein binding ATP binding galactose binding cytoplasm cytosol carbohydrate metabolic process galactose metabolic process kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor galactitol metabolic process galactose catabolic process via UDP-galactose carbohydrate phosphorylation glycolytic process from galactose uc007mjn.1 uc007mjn.2 uc007mjn.3 
ENSMUST00000021116.12 Unk ENSMUST00000021116.12 unkempt family zinc finger, transcript variant 1 (from RefSeq NM_172569.4) A2A853 ENSMUST00000021116.1 ENSMUST00000021116.10 ENSMUST00000021116.11 ENSMUST00000021116.2 ENSMUST00000021116.3 ENSMUST00000021116.4 ENSMUST00000021116.5 ENSMUST00000021116.6 ENSMUST00000021116.7 ENSMUST00000021116.8 ENSMUST00000021116.9 Kiaa1753 NM_172569 Q8BL48 Q8BVI6 Q99JZ8 Q99LL9 UNK_MOUSE Zc3h5 Zc3hdc5 uc007mjp.1 uc007mjp.2 uc007mjp.3 uc007mjp.4 Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BL48-1; Sequence=Displayed; Name=2; IsoId=Q8BL48-2; Sequence=VSP_010274; First expressed at 12 dpc and then expression declines postnatally. Highly expressed in the developing CNS (at protein level). Belongs to the unkempt family. Sequence=BAC98248.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; in utero embryonic development neuron migration RNA binding cytoplasm polysome regulation of translation metal ion binding cell morphogenesis involved in neuron differentiation polysome binding mRNA CDS binding negative regulation of cytoplasmic translation uc007mjp.1 uc007mjp.2 uc007mjp.3 uc007mjp.4 
ENSMUST00000021120.6 Trim47 ENSMUST00000021120.6 tripartite motif-containing 47, transcript variant 1 (from RefSeq NM_001205081.1) A2A862 ENSMUST00000021120.1 ENSMUST00000021120.2 ENSMUST00000021120.3 ENSMUST00000021120.4 ENSMUST00000021120.5 NM_001205081 Q6P249 Q811J7 Q8BVZ8 Q8C0E3 Q8R1K0 Q8R3Y1 TRI47_MOUSE Trim47 uc007mjy.1 uc007mjy.2 uc007mjy.3 uc007mjy.4 E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C0E3-1; Sequence=Displayed; Name=2; IsoId=Q8C0E3-2; Sequence=VSP_011988; Expressed in hepatocytes, expression is increased in fatty livers. Belongs to the TRIM/RBCC family. Sequence=BAC27457.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC35997.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ubiquitin-protein transferase activity nucleus cytoplasm cytosol zinc ion binding protein ubiquitination transferase activity metal ion binding uc007mjy.1 uc007mjy.2 uc007mjy.3 uc007mjy.4 
ENSMUST00000021130.7 Ten1 ENSMUST00000021130.7 TEN1 telomerase capping complex subunit (from RefSeq NM_027107.1) ENSMUST00000021130.1 ENSMUST00000021130.2 ENSMUST00000021130.3 ENSMUST00000021130.4 ENSMUST00000021130.5 ENSMUST00000021130.6 NM_027107 Q9D7K2 TEN1L_MOUSE uc007mkn.1 uc007mkn.2 uc007mkn.3 Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (By similarity). Component of the CST complex, composed of TEN1, CTC1 and STN1; in the complex interacts directly with STN1. Nucleus Chromosome, telomere Belongs to the TEN1 family. chromosome, telomeric region nuclear chromosome, telomeric region DNA binding single-stranded DNA binding nucleus chromosome telomerase inhibitor activity negative regulation of telomere maintenance via telomerase telomeric DNA binding negative regulation of telomerase activity CST complex uc007mkn.1 uc007mkn.2 uc007mkn.3 
ENSMUST00000021133.16 Srp68 ENSMUST00000021133.16 signal recognition particle 68 (from RefSeq NM_146032.3) A2AAN1 ENSMUST00000021133.1 ENSMUST00000021133.10 ENSMUST00000021133.11 ENSMUST00000021133.12 ENSMUST00000021133.13 ENSMUST00000021133.14 ENSMUST00000021133.15 ENSMUST00000021133.2 ENSMUST00000021133.3 ENSMUST00000021133.4 ENSMUST00000021133.5 ENSMUST00000021133.6 ENSMUST00000021133.7 ENSMUST00000021133.8 ENSMUST00000021133.9 NM_146032 Q6NS76 Q8BMA6 SRP68_MOUSE uc007mkq.1 uc007mkq.2 Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity). Heterodimer with SRP72 (By similarity). SRP68/SRP72 heterodimer formation is stabilized by the presence of 7SL RNA (By similarity). Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). Within the SRP complex, interacts (via C-terminus) with SRP72 (via N- terminus) (By similarity). Cytoplasm Nucleus, nucleolus Endoplasmic reticulum The N-terminus is required for RNA-binding. Belongs to the SRP68 family. RNA binding signal recognition particle binding nucleus nucleolus cytoplasm signal recognition particle, endoplasmic reticulum targeting cytosol focal adhesion SRP-dependent cotranslational protein targeting to membrane 7S RNA binding protein domain specific binding endoplasmic reticulum signal peptide binding response to drug ribosome binding signal recognition particle uc007mkq.1 uc007mkq.2 
ENSMUST00000021134.10 Tsen54 ENSMUST00000021134.10 tRNA splicing endonuclease subunit 54 (from RefSeq NM_029557.1) B1ATA4 B1ATA5 ENSMUST00000021134.1 ENSMUST00000021134.2 ENSMUST00000021134.3 ENSMUST00000021134.4 ENSMUST00000021134.5 ENSMUST00000021134.6 ENSMUST00000021134.7 ENSMUST00000021134.8 ENSMUST00000021134.9 NM_029557 Q8C2A2 Q9DCI5 SEN54_MOUSE Sen54 uc007mir.1 uc007mir.2 uc007mir.3 Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity). tRNA splicing endonuclease is a heterotetramer composed of TSEN2, TSEN15, TSEN34/LENG5 and TSEN54. tRNA splicing endonuclease complex also contains proteins of the pre-mRNA 3'-end processing machinery such as CLP1, CPSF1, CPSF4 and CSTF2 (By similarity). Nucleus Nucleus, nucleolus Note=May be transiently localized in the nucleolus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C2A2-1; Sequence=Displayed; Name=2; IsoId=Q8C2A2-2; Sequence=VSP_010990; Belongs to the SEN54 family. tRNA-intron endonuclease complex tRNA-type intron splice site recognition and cleavage nucleus nucleolus tRNA splicing, via endonucleolytic cleavage and ligation mRNA processing tRNA processing RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic tRNA-intron endonuclease activity uc007mir.1 uc007mir.2 uc007mir.3 
ENSMUST00000021135.5 Ncbp3 ENSMUST00000021135.5 nuclear cap binding subunit 3 (from RefSeq NM_025818.3) ENSMUST00000021135.1 ENSMUST00000021135.2 ENSMUST00000021135.3 ENSMUST00000021135.4 NCBP3_MOUSE NM_025818 Ncbp3 Q3TNF4 Q3TQ96 Q4G0C3 Q8BMB1 Q8BZR9 Q9CRM6 Q9CS93 Q9D0G9 Q9DBT0 uc007jzv.1 uc007jzv.2 uc007jzv.3 uc007jzv.4 Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). Component of an alternative cap-binding complex (CBC) composed of NCBP1/CBP80 and NCBP3. Interacts with SRRT, KPNA3, THOC5 and EIF4A3. Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BZR9-1; Sequence=Displayed; Name=2; IsoId=Q8BZR9-2; Sequence=VSP_029001, VSP_029002; Name=3; IsoId=Q8BZR9-3; Sequence=VSP_029000, VSP_029003; Belongs to the NCBP3 family. Sequence=BAB27625.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC28111.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA cap binding RNA 7-methylguanosine cap binding RNA binding mRNA binding nucleus cytoplasm 7-methylguanosine mRNA capping mRNA processing nuclear speck mRNA transport defense response to virus uc007jzv.1 uc007jzv.2 uc007jzv.3 uc007jzv.4 
ENSMUST00000021141.14 P2rx1 ENSMUST00000021141.14 purinergic receptor P2X, ligand-gated ion channel, 1 (from RefSeq NM_008771.3) ENSMUST00000021141.1 ENSMUST00000021141.10 ENSMUST00000021141.11 ENSMUST00000021141.12 ENSMUST00000021141.13 ENSMUST00000021141.2 ENSMUST00000021141.3 ENSMUST00000021141.4 ENSMUST00000021141.5 ENSMUST00000021141.6 ENSMUST00000021141.7 ENSMUST00000021141.8 ENSMUST00000021141.9 NM_008771 P2RX1_MOUSE P51576 Q5SRU4 uc007jzq.1 uc007jzq.2 uc007jzq.3 uc007jzq.4 Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity). Homo- or heteropolymers. Membrane; Multi-pass membrane protein. Belongs to the P2X receptor family. purinergic nucleotide receptor activity serotonin secretion by platelet regulation of vascular smooth muscle contraction extracellular ATP-gated cation channel activity ion channel activity cation channel activity ATP binding integral component of nuclear inner membrane plasma membrane integral component of plasma membrane ion transport apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of smooth muscle contraction insemination drug binding regulation of blood pressure zinc ion binding external side of plasma membrane response to organic substance membrane integral component of membrane neuronal action potential regulation of vasoconstriction platelet activation macromolecular complex response to ATP ion transmembrane transport synaptic transmission, glutamatergic purinergic nucleotide receptor signaling pathway neuron projection positive regulation of ion transport membrane raft postsynaptic membrane ceramide biosynthetic process protein homooligomerization protein heterooligomerization regulation of calcium ion transport excitatory postsynaptic potential cation transmembrane transport glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic active zone membrane regulation of presynaptic cytosolic calcium ion concentration regulation of synaptic vesicle exocytosis uc007jzq.1 uc007jzq.2 uc007jzq.3 uc007jzq.4 
ENSMUST00000021148.13 Ube2g1 ENSMUST00000021148.13 ubiquitin-conjugating enzyme E2G 1 (from RefSeq NM_025985.4) ENSMUST00000021148.1 ENSMUST00000021148.10 ENSMUST00000021148.11 ENSMUST00000021148.12 ENSMUST00000021148.2 ENSMUST00000021148.3 ENSMUST00000021148.4 ENSMUST00000021148.5 ENSMUST00000021148.6 ENSMUST00000021148.7 ENSMUST00000021148.8 ENSMUST00000021148.9 NM_025985 Q5F239 Q5F239_MOUSE Ube2g1 uc007jzd.1 uc007jzd.2 uc007jzd.3 Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence=; Protein modification; protein ubiquitination. Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding ubiquitin-protein transferase activity ATP binding transferase activity ubiquitin protein ligase binding cellular protein catabolic process ubiquitin conjugating enzyme activity protein K63-linked ubiquitination protein K48-linked ubiquitination uc007jzd.1 uc007jzd.2 uc007jzd.3 
ENSMUST00000021155.4 Tekt1 ENSMUST00000021155.4 tektin 1, transcript variant 1 (from RefSeq NM_001282006.1) ENSMUST00000021155.1 ENSMUST00000021155.2 ENSMUST00000021155.3 NM_001282006 Q9DAJ2 TEKT1_MOUSE uc033fxt.1 uc033fxt.2 uc033fxt.3 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Interacts with TEKT3. Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme Belongs to the tektin family. microtubule microtubule cytoskeleton cilium assembly cilium movement involved in cell motility uc033fxt.1 uc033fxt.2 uc033fxt.3 
ENSMUST00000021157.9 Med31 ENSMUST00000021157.9 mediator complex subunit 31 (from RefSeq NM_026068.2) ENSMUST00000021157.1 ENSMUST00000021157.2 ENSMUST00000021157.3 ENSMUST00000021157.4 ENSMUST00000021157.5 ENSMUST00000021157.6 ENSMUST00000021157.7 ENSMUST00000021157.8 MED31_MOUSE NM_026068 Q9CXU1 Q9DAP5 Soh1 uc007jyk.1 uc007jyk.2 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Q9CXU1; Q8C1S0: Med19; NbExp=2; IntAct=EBI-309355, EBI-398761; Nucleus Belongs to the Mediator complex subunit 31 family. ubiquitin ligase complex transcription cofactor activity transcription coactivator activity protein binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein ubiquitination mediator complex negative regulation of fibroblast proliferation limb development ubiquitin protein ligase activity core mediator complex positive regulation of nucleic acid-templated transcription uc007jyk.1 uc007jyk.2 
ENSMUST00000021158.4 Txndc17 ENSMUST00000021158.4 thioredoxin domain containing 17 (from RefSeq NM_026559.3) ENSMUST00000021158.1 ENSMUST00000021158.2 ENSMUST00000021158.3 NM_026559 Q3TE14 Q921A9 Q9CQM5 Q9D0Y4 TXD17_MOUSE Txnl5 uc007jyj.1 uc007jyj.2 uc007jyj.3 Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide (By similarity). Interacts with TRXR1 and DYNLL1/DNCL1. Cytoplasm The oxidized protein is reduced by TRXR1. Belongs to the thioredoxin family. peroxidase activity cytoplasm cytosol tumor necrosis factor-mediated signaling pathway protein-disulfide reductase activity oxidation-reduction process cellular oxidant detoxification uc007jyj.1 uc007jyj.2 uc007jyj.3 
ENSMUST00000021161.14 Slc13a5 ENSMUST00000021161.14 solute carrier family 13 (sodium-dependent citrate transporter), member 5, transcript variant 3 (from RefSeq NM_001372403.1) ENSMUST00000021161.1 ENSMUST00000021161.10 ENSMUST00000021161.11 ENSMUST00000021161.12 ENSMUST00000021161.13 ENSMUST00000021161.2 ENSMUST00000021161.3 ENSMUST00000021161.4 ENSMUST00000021161.5 ENSMUST00000021161.6 ENSMUST00000021161.7 ENSMUST00000021161.8 ENSMUST00000021161.9 NM_001372403 Nact Q67BT3 S13A5_MOUSE uc007jym.1 uc007jym.2 uc007jym.3 uc007jym.4 High-affinity sodium/citrate cotransporter that mediates citrate entry into cells, which is a critical participant of biochemical pathways (PubMed:35448538, PubMed:26324167, PubMed:14656221). May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis (PubMed:12826022). Transports citrate into the cell in a Na(+)-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form (PubMed:12826022, PubMed:14656221, PubMed:26324167). Can recognizes succinate as a substrate, but its affinity for succinate is several fold lower than for citrate (PubMed:26324167, PubMed:14656221). The stoichiometry is probably 4 Na(+) for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic (PubMed:26324167, PubMed:14656221). Involved in the regulation of citrate levels in the brain (PubMed:32682952). Reaction=citrate(out) + 4 Na(+)(out) = citrate(in) + 4 Na(+)(in); Xref=Rhea:RHEA:65664, ChEBI:CHEBI:16947, ChEBI:CHEBI:29101; Evidence= Inhibited by Li(+). Kinetic parameters: KM=35.2 uM for citrate ; pH dependence: Optimum pH is 7.0 for citrate. ; Homodimer. Cell membrane ; Multi-pass membrane protein Mice show increased propensity for epileptic seizures, proepileptogenic neuronal excitability changes in the hippocampus, and significant citrate level alterations in the CSF and brain tissue (PubMed:32682952). Null mice show perturbations in fatty acids, bile acids, and energy metabolites in liver, serum, and brain (PubMed:35448538). Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. organic acid:sodium symporter activity plasma membrane ion transport sodium ion transport tricarboxylic acid transport citrate transmembrane transporter activity succinate transmembrane transporter activity tricarboxylic acid transmembrane transporter activity symporter activity succinate transport citrate transport membrane integral component of membrane basolateral plasma membrane sodium:dicarboxylate symporter activity transmembrane transporter activity tricarboxylic acid transmembrane transport transmembrane transport succinate transmembrane transport organic acid transmembrane transport uc007jym.1 uc007jym.2 uc007jym.3 uc007jym.4 
ENSMUST00000021164.4 Pimreg ENSMUST00000021164.4 PICALM interacting mitotic regulator, transcript variant 1 (from RefSeq NM_144526.4) Cats ENSMUST00000021164.1 ENSMUST00000021164.2 ENSMUST00000021164.3 Fam64a NM_144526 PIMRE_MOUSE Pimreg Q8BFY7 Q8K2Z7 Rcs1 uc007jxz.1 uc007jxz.2 uc007jxz.3 During mitosis, may play a role in the metaphase-to-anaphase transition. Interacts with PICALM; this interaction may target PICALM to the nucleus. During mitosis, associates with HDAC2 and MTA2 subunits of the chromatin-remodeling NuRD complex; this association is strongest at prometaphase and decreases as the cell progresses through metaphase and anaphase. Nucleus Nucleus, nucleolus Note=Partially localizes to the nucleolus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BFY7-1; Sequence=Displayed; Name=2; IsoId=Q8BFY7-2; Sequence=VSP_023998; Mainly expressed in thymus and ovary. Expressed in all T-cell subpopulations isolated from the thymus, macrophages, pro- erythrocytes, granulocytes, mast cells and progenitor cells. Widely expressed at 9.5 dpc, including high levels in the neural tube, somites, the posterior region of the midbrain, olfactory placode and the branchial arches. At 10.5 dpc, reduction of the widespread expression and stronger expression in the neural tube, branchial arches, developing limbs, telencephalon, nasal process, lense vesicle, anterior and posterior regions of the mid- and hindbrain. From 11.5 dpc on, strongly expressed in the genital tubercle and hair and vibrissae follicles. From 12.5 dpc onwards, expression decreases, with a complete lack of expression in the cephalic region and the neural tube at 14.5 dpc. Strongly expressed during limb development, with higher levels in hindlimbs compared to forelimbs and expression slightly more marked in the posterior region of the limb buds. At 11.5 and 12.5 dpc, detected at the distal domain and the underlying mesenchyme, but not in the apical ectodermal ridge. Distally, becomes confined to the digits at 13.5 and 14.5 dpc. The N-terminal destruction box 2 (D-box 2) is required for APC/C ubiquitination and proteasomal degradation. Ubiquitinated by the anaphase-promoting complex/cyclosome (APC/C) complex in the presence of FZR1, leading to its degradation by the proteasome during mitotic exit. However, degradation is not essential for normal mitotic progression within a single cell cycle (By similarity). molecular_function nucleus nucleolus cell cycle cell division uc007jxz.1 uc007jxz.2 uc007jxz.3 
ENSMUST00000021166.6 Cygb ENSMUST00000021166.6 cytoglobin, transcript variant 1 (from RefSeq NM_030206.5) CYGB_MOUSE ENSMUST00000021166.1 ENSMUST00000021166.2 ENSMUST00000021166.3 ENSMUST00000021166.4 ENSMUST00000021166.5 NM_030206 Q9CX80 uc007mlv.1 uc007mlv.2 May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer. Cytoplasm Belongs to the globin family. response to hypoxia catalase activity peroxidase activity oxygen transporter activity iron ion binding cytoplasm response to oxidative stress negative regulation of fibroblast migration oxygen transport nuclear speck fatty acid oxidation oxygen binding heme binding negative regulation of collagen biosynthetic process neuron projection neuronal cell body metal ion binding fatty acid peroxidase activity cellular oxidant detoxification negative regulation of hepatic stellate cell activation uc007mlv.1 uc007mlv.2 
ENSMUST00000021168.14 Wscd1 ENSMUST00000021168.14 WSC domain containing 1, transcript variant 1 (from RefSeq NM_177618.4) ENSMUST00000021168.1 ENSMUST00000021168.10 ENSMUST00000021168.11 ENSMUST00000021168.12 ENSMUST00000021168.13 ENSMUST00000021168.2 ENSMUST00000021168.3 ENSMUST00000021168.4 ENSMUST00000021168.5 ENSMUST00000021168.6 ENSMUST00000021168.7 ENSMUST00000021168.8 ENSMUST00000021168.9 Kiaa0523 NM_177618 Q3TQ40 Q5DU24 Q80XH4 Q8BX34 WSCD1_MOUSE uc007jxv.1 uc007jxv.2 uc007jxv.3 uc007jxv.4 Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. Golgi apparatus membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80XH4-1; Sequence=Displayed; Name=2; IsoId=Q80XH4-2; Sequence=VSP_028209, VSP_028210; Belongs to the WSCD family. Sequence=BAD90411.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component sulfotransferase activity biological_process membrane integral component of membrane uc007jxv.1 uc007jxv.2 uc007jxv.3 uc007jxv.4 
ENSMUST00000021170.9 Mxra7 ENSMUST00000021170.9 matrix-remodelling associated 7, transcript variant 1 (from RefSeq NM_026280.3) A2AA24 B2RVR9 ENSMUST00000021170.1 ENSMUST00000021170.2 ENSMUST00000021170.3 ENSMUST00000021170.4 ENSMUST00000021170.5 ENSMUST00000021170.6 ENSMUST00000021170.7 ENSMUST00000021170.8 MXRA7_MOUSE NM_026280 Q8C6F8 Q9CZH7 uc007mmf.1 uc007mmf.2 uc007mmf.3 uc007mmf.4 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007mmf.1 uc007mmf.2 uc007mmf.3 uc007mmf.4 
ENSMUST00000021173.14 Mfsd11 ENSMUST00000021173.14 major facilitator superfamily domain containing 11, transcript variant 1 (from RefSeq NM_178620.4) A2AA30 A2AA32 B2RQK5 ENSMUST00000021173.1 ENSMUST00000021173.10 ENSMUST00000021173.11 ENSMUST00000021173.12 ENSMUST00000021173.13 ENSMUST00000021173.2 ENSMUST00000021173.3 ENSMUST00000021173.4 ENSMUST00000021173.5 ENSMUST00000021173.6 ENSMUST00000021173.7 ENSMUST00000021173.8 ENSMUST00000021173.9 Et MFS11_MOUSE NM_178620 O54844 Q8BJ51 Q8BJ61 uc007mms.1 uc007mms.2 uc007mms.3 uc007mms.4 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BJ51-1; Sequence=Displayed; Name=2; IsoId=Q8BJ51-2; Sequence=VSP_028189; Widely expressed. Belongs to the unc-93 family. Despite its name it is related to the unc-93 family and not to the major facilitator superfamily. molecular_function cellular_component biological_process membrane integral component of membrane uc007mms.1 uc007mms.2 uc007mms.3 uc007mms.4 
ENSMUST00000021177.15 Sec14l1 ENSMUST00000021177.15 SEC14-like lipid binding 1, transcript variant 1 (from RefSeq NM_028777.4) A2A9B9 A8Y5H7 ENSMUST00000021177.1 ENSMUST00000021177.10 ENSMUST00000021177.11 ENSMUST00000021177.12 ENSMUST00000021177.13 ENSMUST00000021177.14 ENSMUST00000021177.2 ENSMUST00000021177.3 ENSMUST00000021177.4 ENSMUST00000021177.5 ENSMUST00000021177.6 ENSMUST00000021177.7 ENSMUST00000021177.8 ENSMUST00000021177.9 Kiaa4251 NM_028777 Q6A071 Q99J07 Q9DBQ0 S14L1_MOUSE Sec14l1 uc007mnb.1 uc007mnb.2 uc007mnb.3 uc007mnb.4 May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of RIGI, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of RIGI with MAVS/IPS1, an important step in signal propagation. May also regulate the SLC18A3 and SLC5A7 cholinergic transporters. Interacts with RIGI (via tandem CARD domain); the interaction is direct. Interacts (via GOLD domain) with SLC18A3; the interaction is direct. Interacts with SLC5A7 (via GOLD domain); the interaction is direct. Cytoplasm Golgi apparatus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A8Y5H7-1; Sequence=Displayed; Name=2; IsoId=A8Y5H7-2; Sequence=VSP_058109; Name=3; IsoId=A8Y5H7-3; Sequence=VSP_058110; immune system process nucleoplasm cytoplasm Golgi apparatus cytosol negative regulation of signal transduction choline transport negative regulation of RIG-I signaling pathway RIG-I binding innate immune response molecular function regulator uc007mnb.1 uc007mnb.2 uc007mnb.3 uc007mnb.4 
ENSMUST00000021179.4 Vmo1 ENSMUST00000021179.4 vitelline membrane outer layer 1 homolog (chicken) (from RefSeq NM_001013607.1) A2CFA5 ENSMUST00000021179.1 ENSMUST00000021179.2 ENSMUST00000021179.3 Gm741 NM_001013607 Q5SXG7 VMO1_MOUSE uc007jvc.1 uc007jvc.2 Secreted Belongs to the VMO1 family. molecular_function extracellular region biological_process uc007jvc.1 uc007jvc.2 
ENSMUST00000021183.4 Eral1 ENSMUST00000021183.4 Era like 12S mitochondrial rRNA chaperone 1 (from RefSeq NM_022313.2) ENSMUST00000021183.1 ENSMUST00000021183.2 ENSMUST00000021183.3 ERAL1_MOUSE Mera NM_022313 Q6NV78 Q8VE60 Q925U1 Q9CZU4 uc007kia.1 uc007kia.2 uc007kia.3 Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity). Mitochondrion matrix Mitochondrion inner membrane ; Peripheral membrane protein Note=Localizes on the matrix side on the mitochondrial inner membrane. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family. ribosomal small subunit assembly nucleotide binding RNA binding GTP binding mitochondrion mitochondrial inner membrane mitochondrial matrix cytosol membrane rRNA binding ribosome biogenesis ribosomal small subunit binding uc007kia.1 uc007kia.2 uc007kia.3 
ENSMUST00000021187.12 Dhrs13 ENSMUST00000021187.12 dehydrogenase/reductase 13 (from RefSeq NM_183286.2) DHR13_MOUSE Dhrs13 ENSMUST00000021187.1 ENSMUST00000021187.10 ENSMUST00000021187.11 ENSMUST00000021187.2 ENSMUST00000021187.3 ENSMUST00000021187.4 ENSMUST00000021187.5 ENSMUST00000021187.6 ENSMUST00000021187.7 ENSMUST00000021187.8 ENSMUST00000021187.9 NM_183286 Q14BH2 Q5SS80 Q8BMX8 Sdr7c5 uc007khu.1 uc007khu.2 uc007khu.3 Putative oxidoreductase. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SS80-1; Sequence=Displayed; Name=2; IsoId=Q5SS80-2; Sequence=VSP_029641; Belongs to the short-chain dehydrogenases/reductases (SDR) family. Sequence=BAC25347.1; Type=Frameshift; Evidence=; extracellular region oxidoreductase activity oxidation-reduction process uc007khu.1 uc007khu.2 uc007khu.3 
ENSMUST00000021190.9 Coro6 ENSMUST00000021190.9 coronin 6, transcript variant E (from RefSeq NR_160865.1) CORO6_MOUSE ENSMUST00000021190.1 ENSMUST00000021190.2 ENSMUST00000021190.3 ENSMUST00000021190.4 ENSMUST00000021190.5 ENSMUST00000021190.6 ENSMUST00000021190.7 ENSMUST00000021190.8 NR_160865 Q3TZ14 Q5F262 Q5F263 Q5F264 Q5F265 Q920M3 Q920M4 Q920M5 uc007kgs.1 uc007kgs.2 Event=Alternative splicing; Named isoforms=4; Name=A; IsoId=Q920M5-1; Sequence=Displayed; Name=B; IsoId=Q920M5-2; Sequence=VSP_011749; Name=C; IsoId=Q920M5-3; Sequence=VSP_011750; Name=D; IsoId=Q920M5-4; Sequence=VSP_011749, VSP_021487; actin filament organization cell migration actin filament binding uc007kgs.1 uc007kgs.2 
ENSMUST00000021197.10 Blmh ENSMUST00000021197.10 bleomycin hydrolase (from RefSeq NM_178645.4) BLMH_MOUSE ENSMUST00000021197.1 ENSMUST00000021197.2 ENSMUST00000021197.3 ENSMUST00000021197.4 ENSMUST00000021197.5 ENSMUST00000021197.6 ENSMUST00000021197.7 ENSMUST00000021197.8 ENSMUST00000021197.9 NM_178645 Q3TJR8 Q8BLZ4 Q8BZH9 Q8C111 Q8CID9 Q8R016 uc007kge.1 uc007kge.2 uc007kge.3 uc007kge.4 The encoded protein is a cytoplasmic cysteine peptidase involved in inactivation of bleomycin, a glycopeptide which is a component of combination chemotherapy regimens for cancer. This encoded enzyme is highly conserved, and it contains the signature active site residues of cysteine protease papain superfamily enzymes. It is postulated that this enzyme has protective effects against bleomycin-induced pulmonary fibrosis and bleomycin tumor resistance. [provided by RefSeq, Jan 2010]. ##Evidence-Data-START## Transcript exon combination :: AK049461.1, BC027403.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. Reaction=Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.; EC=3.4.22.40; Homohexamer (By similarity). Interacts with NUDT12 (via ANK repeats) (By similarity). Cytoplasm Cytoplasmic granule Note=Co-localizes with NUDT12 in the cytoplasmic granules. Belongs to the peptidase C1 family. cysteine-type endopeptidase activity cytoplasm proteolysis peptidase activity cysteine-type peptidase activity response to toxic substance hydrolase activity response to drug identical protein binding homocysteine catabolic process uc007kge.1 uc007kge.2 uc007kge.3 uc007kge.4 
ENSMUST00000021201.6 Cpd ENSMUST00000021201.6 carboxypeptidase D (from RefSeq NM_007754.2) CBPD_MOUSE ENSMUST00000021201.1 ENSMUST00000021201.2 ENSMUST00000021201.3 ENSMUST00000021201.4 ENSMUST00000021201.5 NM_007754 O89001 Q5SVH8 uc007kga.1 uc007kga.2 uc007kga.3 Reaction=Releases C-terminal Arg and Lys from polypeptides.; EC=3.4.17.22; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Cell membrane ; Single-pass type I membrane protein There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity. Belongs to the peptidase M14 family. carboxypeptidase activity metallocarboxypeptidase activity serine-type carboxypeptidase activity extracellular space nucleus trans-Golgi network plasma membrane proteolysis peptide metabolic process peptidase activity metallopeptidase activity zinc ion binding membrane integral component of membrane protein processing hydrolase activity intracellular membrane-bounded organelle macromolecular complex binding metal ion binding perinuclear region of cytoplasm protein phosphatase 2A binding uc007kga.1 uc007kga.2 uc007kga.3 
ENSMUST00000021203.7 Timm22 ENSMUST00000021203.7 translocase of inner mitochondrial membrane 22, transcript variant 1 (from RefSeq NM_019818.5) ENSMUST00000021203.1 ENSMUST00000021203.2 ENSMUST00000021203.3 ENSMUST00000021203.4 ENSMUST00000021203.5 ENSMUST00000021203.6 NM_019818 Q5SSL1 Q5SSL2 Q8QZU2 Q9CQ85 Q9JKW2 TIM22_MOUSE Tim22 uc007kfq.1 uc007kfq.2 uc007kfq.3 uc007kfq.4 uc007kfq.5 Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein FXC1/TIMM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10 (TIMM10A or TIMM10B). A small fraction of the 70 kDa complex is composed of TIMM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. The TIM22 complex also contains AGK and TIMM29. Interacts directly with TIMM9, TIMM10A and FXC1/TIMM10B. Interacts (when oxidized) with TIMM29; interaction is direct. Mitochondrion inner membrane ; Multi-pass membrane protein Disulfide bonds promote efficient assembly of the TIM22 complex. Belongs to the Tim17/Tim22/Tim23 family. Sequence=CAI25857.1; Type=Erroneous gene model prediction; Evidence=; protein binding mitochondrion mitochondrial inner membrane protein transmembrane transporter activity protein transport membrane integral component of membrane mitochondrion targeting sequence binding mitochondrial inner membrane protein insertion complex protein import into mitochondrial inner membrane protein transmembrane transport uc007kfq.1 uc007kfq.2 uc007kfq.3 uc007kfq.4 uc007kfq.5 
ENSMUST00000021204.4 Nxn ENSMUST00000021204.4 nucleoredoxin (from RefSeq NM_008750.5) ENSMUST00000021204.1 ENSMUST00000021204.2 ENSMUST00000021204.3 Gn25 NM_008750 NXN_MOUSE P97346 Q5H8T6 Q5H8U0 Q99KF3 uc007kfo.1 uc007kfo.2 uc007kfo.3 uc007kfo.4 Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A). Reaction=[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH; Xref=Rhea:RHEA:18749, Rhea:RHEA-COMP:10593, Rhea:RHEA- COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.8.1.8; Evidence=; Reaction=[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:18753, Rhea:RHEA-COMP:10593, Rhea:RHEA- COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.8; Evidence=; Associates with the phosphatase 2A holoenzyme. Interacts with PPP2CA; the interaction is direct. Interacts with DVL1 (via PDZ domain); the interaction is direct and regulated by oxidative stress. P97346; P67775: PPP2CA; Xeno; NbExp=2; IntAct=EBI-309684, EBI-712311; P97346; P30153: PPP2R1A; Xeno; NbExp=2; IntAct=EBI-309684, EBI-302388; P97346; Q9UGP8: SEC63; Xeno; NbExp=6; IntAct=EBI-309684, EBI-1045560; Cytoplasm, cytosol Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P97346-1; Sequence=Displayed; Name=2; IsoId=P97346-2; Sequence=VSP_033396, VSP_033397; Widely expressed with higher expression in testis and skin. Specifically expressed form 9.5 dpc to 12.5 dpc in limb buds. Perinatal lethality, possibly due abnormal cardiovascular development. Osteoblasts show an aberrant activation of the Wnt signaling pathway. Belongs to the nucleoredoxin family. in utero embryonic development thioredoxin-disulfide reductase activity protein binding nucleus cytoplasm cytosol multicellular organism development Wnt signaling pathway oxidoreductase activity cell differentiation negative regulation of Wnt signaling pathway negative regulation of protein ubiquitination cell redox homeostasis protein-disulfide reductase activity oxidation-reduction process cardiovascular system development cellular oxidant detoxification uc007kfo.1 uc007kfo.2 uc007kfo.3 uc007kfo.4 
ENSMUST00000021207.7 Rflnb ENSMUST00000021207.7 refilin B (from RefSeq NM_029658.1) Cfm1 ENSMUST00000021207.1 ENSMUST00000021207.2 ENSMUST00000021207.3 ENSMUST00000021207.4 ENSMUST00000021207.5 ENSMUST00000021207.6 Fam101b NM_029658 Q5SVD0 Q9DB69 RFLB_MOUSE Rflnb uc007kez.1 uc007kez.2 uc007kez.3 uc007kez.4 Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. Interacts with FLNA and FLNB. Cytoplasm, cytoskeleton Note=Colocalizes with FLNA along actin bundle-like structures. Detected in various tissues, with highest expression in lung, followed by spleen. At 15.5 dpc, expressed in developing ribs and nucleus pulposus in intervertebral disks. At 18.5 dpc, expression is detected in proliferating and prehypertrophic chondrocytes. No visible phenotype; probably due to redundancy with RFLN. RFLNA and RFLNB double mutant mice exhibit severe skeletal malformations, as characterized by scoliosis, kyphosis, intervertebral disks defects, vertebral fusion in the spine and longitudinal bone growth retardation. Chondrocyte maturation is accelerated in double mutant mice. Belongs to the Refilin family. epithelial to mesenchymal transition cytoplasm cytoskeleton actin cytoskeleton actin cytoskeleton organization filamin binding actin filament bundle skeletal system morphogenesis regulation of chondrocyte development negative regulation of chondrocyte development actin filament bundle organization negative regulation of bone mineralization involved in bone maturation uc007kez.1 uc007kez.2 uc007kez.3 uc007kez.4 
ENSMUST00000021209.8 Doc2b ENSMUST00000021209.8 double C2, beta (from RefSeq NM_007873.3) DOC2B_MOUSE ENSMUST00000021209.1 ENSMUST00000021209.2 ENSMUST00000021209.3 ENSMUST00000021209.4 ENSMUST00000021209.5 ENSMUST00000021209.6 ENSMUST00000021209.7 NM_007873 P70169 Q5SS41 Q6NXK3 uc007kev.1 uc007kev.2 uc007kev.3 uc007kev.4 uc007kev.5 The protein encoded by this gene is a calcium sensor involved in glucose-stimulated insulin secretion, spontaneous neurotransmitter release, and enhanced SNARE-dependent vesicle fusion. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC067030.1, D85037.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium- dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium- triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with cytoplasmic dynein light chain DYNLT1. May interact with UNC13A; the interaction mediates targeting to the plasma membrane (By similarity). Probably interacts with the SNARE (soluble N- ethylmaleimide-sensitive factor attached protein receptor) complex composed of SNAP25, STX1A and VAMP2; the interaction is calcium- dependent and competitive with SYT1. Interacts with STX4; the interaction is calcium-dependent, increased by insulin and glucose, and mediates vesicle fusion with plasma membrane in pancreatic cells and adipocytes. Interacts with STXBP3; the interaction is direct, occurs at the cell membrane and regulates glucose-stimulated insulin secretion. Cytoplasm. Cytoplasmic granule. Cell membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane in a calcium-dependent manner. Widely expressed. Expressed in pancreatic islet cells (at protein level). C2 domain 1 is involved in binding calcium and phospholipids. According to PubMed:19033398, the C2 domain 2 may also play a role in the calcium-dependent targeting to membranes. Mice are viable and fertile without gross abnormalities. calcium ion binding protein binding calcium-dependent phospholipid binding cytoplasm plasma membrane protein localization membrane syntaxin binding positive regulation of vesicle fusion positive regulation of insulin secretion positive regulation of calcium ion-dependent exocytosis calcium ion-regulated exocytosis of neurotransmitter spontaneous neurotransmitter secretion presynapse SNARE complex uc007kev.1 uc007kev.2 uc007kev.3 uc007kev.4 uc007kev.5 
ENSMUST00000021217.11 Nme2 ENSMUST00000021217.11 NME/NM23 nucleoside diphosphate kinase 2, transcript variant 1 (from RefSeq NM_008705.5) ENSMUST00000021217.1 ENSMUST00000021217.10 ENSMUST00000021217.2 ENSMUST00000021217.3 ENSMUST00000021217.4 ENSMUST00000021217.5 ENSMUST00000021217.6 ENSMUST00000021217.7 ENSMUST00000021217.8 ENSMUST00000021217.9 NM_008705 Nme2 Q5NC82 Q5NC82_MOUSE uc007kxt.1 uc007kxt.2 uc007kxt.3 uc007kxt.4 Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L- histidine.; EC=2.7.13.3; Evidence=; Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence= Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm Belongs to the NDK family. nucleotide binding ruffle negative regulation of myeloid leukocyte differentiation DNA binding transcription coactivator activity nucleoside diphosphate kinase activity protein serine/threonine kinase activity fatty acid binding ATP binding cytoplasm intermediate filament nucleoside diphosphate phosphorylation GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process adenylate cyclase-activating G-protein coupled receptor signaling pathway integrin-mediated signaling pathway drug binding nucleoside triphosphate biosynthetic process positive regulation of neuron projection development kinase activity phosphorylation transferase activity GDP binding intermediate filament binding enzyme binding lamellipodium mitochondrial membrane cellular response to oxidative stress negative regulation of apoptotic process positive regulation of keratinocyte differentiation regulation of epidermis development positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation perinuclear region of cytoplasm positive regulation of epithelial cell proliferation protein oligomerization G-quadruplex DNA binding response to growth hormone cellular response to glucose stimulus cellular response to fatty acid cell periphery uc007kxt.1 uc007kxt.2 uc007kxt.3 uc007kxt.4 
ENSMUST00000021239.7 Lrrc59 ENSMUST00000021239.7 leucine rich repeat containing 59 (from RefSeq NM_133807.2) ENSMUST00000021239.1 ENSMUST00000021239.2 ENSMUST00000021239.3 ENSMUST00000021239.4 ENSMUST00000021239.5 ENSMUST00000021239.6 LRC59_MOUSE NM_133807 Q3TJ35 Q3TLC7 Q3TWT9 Q3TX86 Q922Q8 uc007kze.1 uc007kze.2 uc007kze.3 Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity). Can form homodimers. Interacts with SGO1. Interacts with FGF1. Microsome membrane ; Single-pass type II membrane protein Endoplasmic reticulum membrane ; Single-pass type II membrane protein Nucleus envelope Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1. Sequence=AAH06877.1; Type=Erroneous initiation; Evidence=; Sequence=BAE35030.1; Type=Erroneous initiation; Evidence=; Sequence=BAE38865.1; Type=Erroneous initiation; Evidence=; Sequence=BAE39660.1; Type=Erroneous initiation; Evidence=; nucleus nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane organelle membrane mitochondrial nucleoid intracellular membrane-bounded organelle uc007kze.1 uc007kze.2 uc007kze.3 
ENSMUST00000021240.7 Cdc34b ENSMUST00000021240.7 Belongs to the ubiquitin-conjugating enzyme family. (from UniProt A0A140T8I4) A0A140T8I4 A0A140T8I4_MOUSE Cdc34b ENSMUST00000021240.1 ENSMUST00000021240.2 ENSMUST00000021240.3 ENSMUST00000021240.4 ENSMUST00000021240.5 ENSMUST00000021240.6 LF198789 uc288bmy.1 uc288bmy.2 Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding ATP binding transferase activity uc288bmy.1 uc288bmy.2 
ENSMUST00000021241.8 Dlx4 ENSMUST00000021241.8 distal-less homeobox 4 (from RefSeq NM_007867.4) DLX4_MOUSE Dlx7 ENSMUST00000021241.1 ENSMUST00000021241.2 ENSMUST00000021241.3 ENSMUST00000021241.4 ENSMUST00000021241.5 ENSMUST00000021241.6 ENSMUST00000021241.7 NM_007867 P70436 Q3UM51 Q8R4I3 uc007kzz.1 uc007kzz.2 uc007kzz.3 uc007kzz.4 May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis. Nucleus Branchial arches, molar and incisor teeth and limbs. Expressed in the mesenchyme of the anterior palate at 12.5 dpc, prior to the time of palate closure. Expression levels decrease at later time periods after palate closure. Belongs to the distal-less homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc007kzz.1 uc007kzz.2 uc007kzz.3 uc007kzz.4 
ENSMUST00000021242.5 Tac4 ENSMUST00000021242.5 tachykinin 4 (from RefSeq NM_053093.2) ENSMUST00000021242.1 ENSMUST00000021242.2 ENSMUST00000021242.3 ENSMUST00000021242.4 NM_053093 Q99N14 TKN4_MOUSE Tac4 uc007lac.1 uc007lac.2 uc007lac.3 uc007lac.4 Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior. Increases sperm motility. Induces potent analgesic effects and may play a role in pain modulation. Promotes survival of bone marrow B lineage cells and of cultured LPS-stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and proliferation. Lowers systemic arterial pressure following intravenous injection. Induces interferon- gamma production and may play a role in the inflammatory response. Shows potent affinity and specificity for the NK-1 receptor. Secreted Expressed in hematopoietic cells with highest levels in pre- and pro-B cells but not in later developmental stages. Also detected in uterus, skeletal muscle, brain, spleen, stomach, skin and lactating mammary gland and in cells of myeloid lineage including dendritic and microglial cells and macrophages. In uterus, highest expression is observed in non-pregnant diestrus mice and in day 5 pregnant mice. Compared with mice in diestrus, decreases 2.6-fold in uteri from non-pregnant mice in estrus and 10.2-fold in day 17 pregnant mice. Detected at sites of chronic inflammation such as granulomas. Belongs to the tachykinin family. receptor binding extracellular region extracellular space cell inflammatory response positive regulation of cytosolic calcium ion concentration tachykinin receptor signaling pathway regulation of blood pressure substance P receptor binding substance K receptor binding mast cell granule mast cell degranulation positive regulation of saliva secretion receptor agonist activity uc007lac.1 uc007lac.2 uc007lac.3 uc007lac.4 
ENSMUST00000021243.16 Slc35b1 ENSMUST00000021243.16 solute carrier family 35, member B1, transcript variant 1 (from RefSeq NM_016752.4) ENSMUST00000021243.1 ENSMUST00000021243.10 ENSMUST00000021243.11 ENSMUST00000021243.12 ENSMUST00000021243.13 ENSMUST00000021243.14 ENSMUST00000021243.15 ENSMUST00000021243.2 ENSMUST00000021243.3 ENSMUST00000021243.4 ENSMUST00000021243.5 ENSMUST00000021243.6 ENSMUST00000021243.7 ENSMUST00000021243.8 ENSMUST00000021243.9 NM_016752 P97858 Q8CF70 S35B1_MOUSE Ugalt2 uc007lah.1 uc007lah.2 uc007lah.3 ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction. Regulates ER energy metabolism and protein biogenesis. Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply. Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER. Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established. Reaction=ADP(in) + ATP(out) = ADP(out) + ATP(in); Xref=Rhea:RHEA:34999, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:35001; Evidence=; Reaction=ATP(in) + UDP(out) = ATP(out) + UDP(in); Xref=Rhea:RHEA:73707, ChEBI:CHEBI:30616, ChEBI:CHEBI:58223; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73708; Evidence=; Reaction=ATP(in) + UTP(out) = ATP(out) + UTP(in); Xref=Rhea:RHEA:73711, ChEBI:CHEBI:30616, ChEBI:CHEBI:46398; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73712; Evidence=; Reaction=ATP(in) + dATP(out) = ATP(out) + dATP(in); Xref=Rhea:RHEA:73715, ChEBI:CHEBI:30616, ChEBI:CHEBI:61404; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73716; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P97858-1; Sequence=Displayed; Name=2; IsoId=P97858-2; Sequence=VSP_016192; The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins. Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. UDP-galactose transmembrane transporter activity UDP-glucose transmembrane transporter activity endoplasmic reticulum endoplasmic reticulum membrane carbohydrate transport UDP-glucose transport membrane integral component of membrane transmembrane transporter activity integral component of Golgi membrane integral component of endoplasmic reticulum membrane transmembrane transport UDP-galactose transmembrane transport uc007lah.1 uc007lah.2 uc007lah.3 
ENSMUST00000021246.9 Snx11 ENSMUST00000021246.9 sorting nexin 11 (from RefSeq NM_028965.4) ENSMUST00000021246.1 ENSMUST00000021246.2 ENSMUST00000021246.3 ENSMUST00000021246.4 ENSMUST00000021246.5 ENSMUST00000021246.6 ENSMUST00000021246.7 ENSMUST00000021246.8 NM_028965 Q3V3A6 Q91WL6 SNX11_MOUSE uc007lci.1 uc007lci.2 uc007lci.3 uc007lci.4 Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Monomer. Membrane ; Peripheral membrane protein ; Cytoplasmic side Endosome The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate. Belongs to the sorting nexin family. endosome intracellular protein transport lipid binding protein transport membrane vesicle organization phosphatidylinositol binding phosphatidylinositol phosphate binding uc007lci.1 uc007lci.2 uc007lci.3 uc007lci.4 
ENSMUST00000021249.11 Scrn2 ENSMUST00000021249.11 secernin 2 (from RefSeq NM_146027.2) ENSMUST00000021249.1 ENSMUST00000021249.10 ENSMUST00000021249.2 ENSMUST00000021249.3 ENSMUST00000021249.4 ENSMUST00000021249.5 ENSMUST00000021249.6 ENSMUST00000021249.7 ENSMUST00000021249.8 ENSMUST00000021249.9 NM_146027 Q8VCA8 SCRN2_MOUSE uc007ldk.1 uc007ldk.2 uc007ldk.3 uc007ldk.4 Belongs to the peptidase C69 family. Secernin subfamily. molecular_function proteolysis dipeptidase activity uc007ldk.1 uc007ldk.2 uc007ldk.3 uc007ldk.4 
ENSMUST00000021251.7 Lrrc46 ENSMUST00000021251.7 leucine rich repeat containing 46 (from RefSeq NM_027026.2) ENSMUST00000021251.1 ENSMUST00000021251.2 ENSMUST00000021251.3 ENSMUST00000021251.4 ENSMUST00000021251.5 ENSMUST00000021251.6 LRC46_MOUSE NM_027026 Q8R1Z3 Q9DAP0 uc007ldl.1 uc007ldl.2 uc007ldl.3 molecular_function uc007ldl.1 uc007ldl.2 uc007ldl.3 
ENSMUST00000021259.9 Gucy2e ENSMUST00000021259.9 guanylate cyclase 2e (from RefSeq NM_008192.3) B1ASX7 ENSMUST00000021259.1 ENSMUST00000021259.2 ENSMUST00000021259.3 ENSMUST00000021259.4 ENSMUST00000021259.5 ENSMUST00000021259.6 ENSMUST00000021259.7 ENSMUST00000021259.8 GUC2E_MOUSE Guc2e NM_008192 P52785 uc007jpn.1 uc007jpn.2 uc007jpn.3 Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:21598940). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (PubMed:17255100). Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2; Evidence=; Activated by GUCA1A when free calcium ions concentration is low, and inhibited by GUCA1A when free calcium ions concentration is high (PubMed:21598940). Negatively regulated by RD3; RD3 inhibits the basal and GUCA1A-stimulated guanylate cyclase activity (By similarity). Kinetic parameters: KM=0.64 mM for GTP (in presence of GUCA1A) ; KM=0.7 mM for GTP (in presence of GUCA1B) ; KM=1.55 nM for GTP ; Homodimer; requires homodimerization for guanylyl cyclase activity (By similarity). Interacts (via C-terminus) with RD3 (via C- terminus); promotes the exit of GUCY2E from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (By similarity). Interaction with RD3 negatively regulates GUCY2E guanylate cyclase activity (By similarity). Photoreceptor outer segment membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds. Deficient mice exhibit abnormal retinal cone cell morphology, impaired cone and rod electrophysiology, and severe retinal cone cell degeneration. GUCY2E and GUCY2F double knockout mice does not show any photoresponse, their rods and cones degenerate and the intracellular transport of some phototransduction proteins is impaired. The gene name nomenclature of retinal guanylyl cyclase 1 is confusing; for mouse the gene name is GUCY2E whereas the gene name is GUCY2D for human and rat orthologs. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding peptide receptor activity guanylate cyclase activity protein kinase activity ATP binding GTP binding plasma membrane cGMP biosynthetic process protein phosphorylation signal transduction receptor guanylyl cyclase signaling pathway visual perception cyclic nucleotide biosynthetic process membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity natriuretic peptide receptor activity peptide hormone binding cGMP-mediated signaling intracellular signal transduction protein homodimerization activity protein heterodimerization activity response to stimulus uc007jpn.1 uc007jpn.2 uc007jpn.3 
ENSMUST00000021262.10 Alox8 ENSMUST00000021262.10 arachidonate 8-lipoxygenase (from RefSeq NM_009661.4) ALOX8_MOUSE Alox15b Alox8 B1ASX5 ENSMUST00000021262.1 ENSMUST00000021262.2 ENSMUST00000021262.3 ENSMUST00000021262.4 ENSMUST00000021262.5 ENSMUST00000021262.6 ENSMUST00000021262.7 ENSMUST00000021262.8 ENSMUST00000021262.9 NM_009661 O35936 uc007jpm.1 uc007jpm.2 uc007jpm.3 uc007jpm.4 This gene belongs to the lipoxygenase (LOX) gene family whose members encode enzymes that catalyze the addition of molecular oxygen to polyunsaturated fatty acids (PUFAs) to yield fatty acid hydroperoxides. The encoded enzyme preferentially metabolizes arachidonic acid to yield 8-hydroxyeicosatetraenoic acid (8-HETE), while metabolizing linoleic acid less efficiently. The gene may also function as a tumor suppressor. This gene is located in a cluster of related genes that spans approximately 75 kilobases on chromosome 11. [provided by RefSeq, Jan 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028724.1, Y14696.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164136 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:9305900, PubMed:10965849, PubMed:10625675, PubMed:16143298, PubMed:16112079, PubMed:15558016, PubMed:27435673). Catalyzes the peroxidation of arachidonate and linoleate into (8S)-HPETE and (9S)- HPODE respectively (PubMed:9305900, PubMed:10965849, PubMed:10625675, PubMed:16143298, PubMed:16112079, PubMed:15558016, PubMed:27435673). In addition to generate (8S)-HPETE from free arachidonic acid (AA), may produce other HETE isomers from phospholipid-esterified polyunsaturated fatty acids and minor products derived from (8S)-HPETE itself that may include leukotriene A4 and 8,15-diHPETE (PubMed:16143298, PubMed:16112079, PubMed:27435673). With free arachidonate as substrate, has no detectable 15S-lipoxygenase activity and only displays a 8S- lipoxygenase activity (PubMed:10625675, PubMed:16112079, PubMed:16143298, PubMed:15558016, PubMed:10965849, PubMed:9305900). However may have a 15S-lipoxygenase activity with (8S)-HPETE to produce (8S,15S)-diHPETE and when oxidizes directly arachidonic acid esterified to membrane-bound phospholipids to produce a phospholipid-esterified 15-HpETE (PubMed:27435673, PubMed:16112079, PubMed:16143298). May also catalyze (15S)-HPETE peroxidation to produce 8,15-diHPETE (PubMed:16112079). May play a role in keratinocyte differentiation through activation of the peroxisome proliferator activated receptor signaling pathway (PubMed:10965849). Reaction=(9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)- octadecadienoate; Xref=Rhea:RHEA:30291, ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:60955; EC=1.13.11.58; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30292; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8S)-hydroperoxy- (5Z,9E,11Z,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:38675, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:75322; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38676; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:50972, ChEBI:CHEBI:15379, ChEBI:CHEBI:57446, ChEBI:CHEBI:133899; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50973; Evidence=; Reaction=(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:50932, ChEBI:CHEBI:15379, ChEBI:CHEBI:75322, ChEBI:CHEBI:133899; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50933; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + O2 = 1-octadecanoyl-2-(15-hydroperoxy- 5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:63264, ChEBI:CHEBI:15379, ChEBI:CHEBI:74965, ChEBI:CHEBI:146283; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63265; Evidence=; Reaction=a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3- phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy- 5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo- inositol); Xref=Rhea:RHEA:63276, ChEBI:CHEBI:15379, ChEBI:CHEBI:75243, ChEBI:CHEBI:146285; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63277; Evidence=; Reaction=a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho- (1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E- eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol); Xref=Rhea:RHEA:63280, ChEBI:CHEBI:15379, ChEBI:CHEBI:146286, ChEBI:CHEBI:146287; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63281; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9-hydroperoxy- (5Z,7E,11Z,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:63288, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:146289; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63289; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11-hydroperoxy- (5Z,8Z,12E,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:63308, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:146291; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63309; Evidence=; Reaction=(8Z,11Z,14Z)-eicosatrienoate + O2 = 15-hydroperoxy- (8Z,11Z,13E)-eicosatrienoate; Xref=Rhea:RHEA:63312, ChEBI:CHEBI:15379, ChEBI:CHEBI:71589, ChEBI:CHEBI:146292; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63313; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence= Note=Binds 1 Fe cation per subunit. Kinetic parameters: KM=1.2 uM for arachidonate (at pH 7.4 and 25 degrees Celsius) ; KM=2.1 uM for (8S)-HPETE (at pH 7.4 and 25 degrees Celsius) ; KM=5.7 uM for (8S)-HETE (at pH 7.4 and 25 degrees Celsius) ; KM=39 uM for (15S)-HPETE (at pH 7.4 and 25 degrees Celsius) ; KM=15 uM for (15S)-HETE (at pH 7.4 and 25 degrees Celsius) ; KM=2.86 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoate ; KM=0.964 uM for (8Z,11Z,14Z)-eicosatrienoate ; Note=The highest catalytic efficiency is observed with arachidonate followed by (8S)-HPETE and(15S)-HPETE with similar efficiencies (PubMed:16112079). kcat is 0.22 sec(-1) for (5Z,8Z,11Z,14Z)- eicosatetraenoate. kcat is 0.045 sec(-1) for (8Z,11Z,14Z)- eicosatrienoate (PubMed:27435673). Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. Cytoplasm, cytosol Membrane ; Peripheral membrane protein Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. Expressed in epidermis and brain (PubMed:9305900, PubMed:9518531). No expression found in heart, spleen, liver, skeletal muscle, kidney or testis. By phorbol ester. The PLAT domain can bind calcium ions; this promotes association with membranes. Belongs to the lipoxygenase family. iron ion binding calcium ion binding cytoplasm cytosol cytoskeleton plasma membrane lipid metabolic process negative regulation of cell proliferation lipid binding positive regulation of macrophage derived foam cell differentiation membrane linoleate 13S-lipoxygenase activity oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen arachidonic acid metabolic process lipoxygenase pathway extrinsic component of membrane positive regulation of peroxisome proliferator activated receptor signaling pathway arachidonate 8(S)-lipoxygenase activity linoleic acid metabolic process positive regulation of keratinocyte differentiation negative regulation of cell cycle negative regulation of growth metal ion binding arachidonate 15-lipoxygenase activity hepoxilin biosynthetic process dioxygenase activity oxidation-reduction process positive regulation of chemokine secretion uc007jpm.1 uc007jpm.2 uc007jpm.3 uc007jpm.4 
ENSMUST00000021268.9 Aloxe3 ENSMUST00000021268.9 arachidonate lipoxygenase 3 (from RefSeq NM_011786.2) Aloxe3 B1ASX3 ENSMUST00000021268.1 ENSMUST00000021268.2 ENSMUST00000021268.3 ENSMUST00000021268.4 ENSMUST00000021268.5 ENSMUST00000021268.6 ENSMUST00000021268.7 ENSMUST00000021268.8 LOXE3_MOUSE NM_011786 Q9WV07 uc007jpj.1 uc007jpj.2 uc007jpj.3 uc007jpj.4 Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity (PubMed:17045234). The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin- type epoxyalcohols and ketones (PubMed:17045234). In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega- hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (By similarity). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:22832496). In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (By similarity). Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (PubMed:20530198). Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (By similarity). Reaction=a hydroperoxyeicosatetraenoate = a hydroxy-epoxy- eicosatetraenoate; Xref=Rhea:RHEA:55560, ChEBI:CHEBI:59720, ChEBI:CHEBI:137328; EC=5.4.4.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55561; Evidence=; Reaction=(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = (10R)- hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:37931, ChEBI:CHEBI:75322, ChEBI:CHEBI:75327; EC=5.4.4.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37932; Evidence=; Reaction=(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)- hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate; Xref=Rhea:RHEA:37939, ChEBI:CHEBI:75230, ChEBI:CHEBI:75232; EC=5.4.4.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37940; Evidence=; Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)- hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate; Xref=Rhea:RHEA:37955, ChEBI:CHEBI:57444, ChEBI:CHEBI:75233; EC=5.4.4.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37956; Evidence=; Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (10R)- hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:37951, ChEBI:CHEBI:57444, ChEBI:CHEBI:75234; EC=5.4.4.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37952; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13R)- hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:37959, ChEBI:CHEBI:57446, ChEBI:CHEBI:75235; EC=5.4.4.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37960; Evidence=; Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy- (12S,13S)-epoxy-(9Z)-octadecenoate; Xref=Rhea:RHEA:50212, ChEBI:CHEBI:57466, ChEBI:CHEBI:132064; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50213; Evidence=; Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 7R- hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:41251, ChEBI:CHEBI:57450, ChEBI:CHEBI:77919; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41252; Evidence=; Reaction=N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl- beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine = N-[omega-(9R,10R)- epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl- (1<->1)-octadecasphing-4E-enine; Xref=Rhea:RHEA:40503, ChEBI:CHEBI:134624, ChEBI:CHEBI:134626; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40504; Evidence=; Reaction=N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine = N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)- octadecenoate (4E)-octadecasphin-4-enine; Xref=Rhea:RHEA:41243, ChEBI:CHEBI:77889, ChEBI:CHEBI:77891; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41244; Evidence=; Reaction=a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O; Xref=Rhea:RHEA:55556, ChEBI:CHEBI:15377, ChEBI:CHEBI:59720, ChEBI:CHEBI:131859; EC=4.2.1.152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55557; Evidence=; Reaction=(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo- (5Z,9E,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37935, ChEBI:CHEBI:15377, ChEBI:CHEBI:57447, ChEBI:CHEBI:75326; EC=4.2.1.152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37936; Evidence=; Reaction=(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo- (5Z,9E,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37927, ChEBI:CHEBI:15377, ChEBI:CHEBI:75322, ChEBI:CHEBI:75326; EC=4.2.1.152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37928; Evidence=; Reaction=(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo- (5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37943, ChEBI:CHEBI:15377, ChEBI:CHEBI:75230, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37944; Evidence=; Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo- (5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37947, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37948; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo- (5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48637; Evidence=; Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)- octadecadienoate + H2O; Xref=Rhea:RHEA:48716, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:90781; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48717; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Note=Binds 1 Fe cation per subunit. Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. Lipid metabolism; sphingolipid metabolism. Cytoplasm Skin specific. Mice die within 5 to 12 hours after birth due to defective skin barrier function loosing around 2.5% of body weight per hour. Dehydratation through the skin is increased 4 folds. The outside- in barrier acquisition is also affected, the skin remaining permeable at 18.5 dpc while it is impermeable in wild-type mice. The stratum corneum is more tightly packed while other layers are unaffected. Hyperkeratosis of the skin is observed but it is not associated with defects in epidermal differentiation while the ceramide composition of the epidermis is altered with an absence of ester-bound ceramides. Belongs to the lipoxygenase family. catalytic activity iron ion binding cytoplasm lipid metabolic process fatty acid metabolic process sphingolipid metabolic process oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen lyase activity isomerase activity sensory perception of pain arachidonic acid metabolic process lipoxygenase pathway peroxisome proliferator activated receptor signaling pathway linoleic acid metabolic process fat cell differentiation ceramide biosynthetic process metal ion binding hepoxilin A3 synthase activity hepoxilin biosynthetic process dioxygenase activity oxidation-reduction process establishment of skin barrier epidermis development bicellular tight junction assembly uc007jpj.1 uc007jpj.2 uc007jpj.3 uc007jpj.4 
ENSMUST00000021271.14 Per1 ENSMUST00000021271.14 period circadian clock 1, transcript variant 1 (from RefSeq NM_011065.5) B1ASX0 ENSMUST00000021271.1 ENSMUST00000021271.10 ENSMUST00000021271.11 ENSMUST00000021271.12 ENSMUST00000021271.13 ENSMUST00000021271.2 ENSMUST00000021271.3 ENSMUST00000021271.4 ENSMUST00000021271.5 ENSMUST00000021271.6 ENSMUST00000021271.7 ENSMUST00000021271.8 ENSMUST00000021271.9 NM_011065 O35973 PER1_MOUSE Per Rigui uc007jpg.1 uc007jpg.2 uc007jpg.3 uc007jpg.4 uc007jpg.5 This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]. Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post- translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR- induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. Homodimer (PubMed:22331899). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins (PubMed:11779462). Interacts directly with TIMELESS (PubMed:10231394, PubMed:9856465). Interacts directly with PER2, PER3, CRY1 and CRY2 (PubMed:10428031, PubMed:10848614, PubMed:11875063, PubMed:14701732, PubMed:16478995, PubMed:24154698). Interacts with BMAL1 and CLOCK (PubMed:16717091, PubMed:24154698). Interacts with GPRASP1 (By similarity). Interacts (phosphorylated) with BTRC and FBXW11; the interactions trigger proteasomal degradation (By similarity). Interacts with NONO and SFPQ (PubMed:22966205). Interacts with WDR5 (By similarity). Interacts with U2AF1L4 (Isoform 3) (PubMed:24837677). Interacts with USP2 (PubMed:23213472). Interacts with HNF4A (By similarity). O35973; P97784: Cry1; NbExp=3; IntAct=EBI-1266764, EBI-1266607; O35973; Q9R194: Cry2; NbExp=3; IntAct=EBI-1266764, EBI-1266619; O35973; Q9JMK2: Csnk1e; NbExp=2; IntAct=EBI-1266764, EBI-771709; O35973; O54943: Per2; NbExp=5; IntAct=EBI-1266764, EBI-1266779; O35973; Q9R1X4: Timeless; NbExp=3; IntAct=EBI-1266764, EBI-1793117; Nucleus. Cytoplasm. Note=Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2. In brain, highest expression is observed in the SCN. Highly expressed in the pyramidal cell layer of the piriform cortex, the periventricular part of the caudate-putamen, many thalamic nuclei, and the granular layer of the cerebellar cortex. Weaker expression is detected in most area of the brain, including cortical and non cortical structures. Expression but no oscillations occurs in the glomerular and mitral cell layers of the olfactory bulb, the internal granular layer of the cerebellum, the cornu ammonis and dentate gyrus of the hippocampus, the cerebral and piriform cortices. Expressed in the renal cortex (at protein level). Also found in heart, brain, bladder, lumbar spinal cord, spleen, lung, liver, skeletal muscle and testis. Expressed in the suprachiasmatic nucleus (SCN) during late fetal and early neonatal life. In the suprachiasmatic nucleus (SCN), behaves like a day- type oscillator, with maximum expression during the light period. Oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. There is a 4 hour time delay between PER1 and PER2 oscillations. The expression rhythms appear to originate from retina. In liver, peak levels at CT9. In the SCN, levels increase by light exposure during subjective night. Circadian oscillations also observed in skeletal muscle, bladder, lumbar spinal cord and liver but not in testis. Phosphorylated on serine residues by CSNK1D, CSNK1E and probably also by CSNK1G2. Phosphorylation by CSNK1D or CSNK1E promotes nuclear location of PER proteins as well as ubiquitination and subsequent degradation. May be dephosphorylated by PP1. Ubiquitinated; requires phosphorylation by CSNK1E and interaction with BTRC and FBXW11. Deubiquitinated by USP2. Animals show disrupted circadian behavior. The prolongation of light exposure produces larger phase delay of behavioral rhythm compared to wild-types. Double knocknouts for PER2 and PER1 show an abrupt loss of rhythmicity immediately upon transfer to exprosure to constant darkness. Animals have largely affected the water intake (polydipsia) and urine volume (polyuria). negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription corepressor binding regulation of sodium ion transport protein binding nucleus nucleoplasm cytoplasm cytosol circadian rhythm transcription factor binding response to light stimulus posttranscriptional regulation of gene expression kinase binding chromatin DNA binding ubiquitin protein ligase binding circadian regulation of gene expression regulation of hair cycle regulation of circadian rhythm negative regulation of I-kappaB kinase/NF-kappaB signaling entrainment of circadian clock by photoperiod histone H3 acetylation histone H4 acetylation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade rhythmic process response to cAMP E-box binding histone H3 deacetylation circadian regulation of translation regulation of cytokine production involved in inflammatory response regulation of p38MAPK cascade negative regulation of glucocorticoid receptor signaling pathway uc007jpg.1 uc007jpg.2 uc007jpg.3 uc007jpg.4 uc007jpg.5 
ENSMUST00000021273.13 Vamp2 ENSMUST00000021273.13 vesicle-associated membrane protein 2 (from RefSeq NM_009497.3) ENSMUST00000021273.1 ENSMUST00000021273.10 ENSMUST00000021273.11 ENSMUST00000021273.12 ENSMUST00000021273.2 ENSMUST00000021273.3 ENSMUST00000021273.4 ENSMUST00000021273.5 ENSMUST00000021273.6 ENSMUST00000021273.7 ENSMUST00000021273.8 ENSMUST00000021273.9 NM_009497 Q8CHR4 Q8CHR4_MOUSE Vamp2 uc007jpe.1 uc007jpe.2 uc007jpe.3 Cell membrane Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type IV membrane protein Membrane ; Single-pass type IV membrane protein Belongs to the synaptobrevin family. SNARE binding plasma membrane synaptic vesicle protein C-terminus binding voltage-gated potassium channel complex response to glucose protein transport membrane integral component of membrane synaptic vesicle exocytosis vesicle-mediated transport myosin binding syntaxin-1 binding regulation of exocytosis secretory granule integral component of synaptic vesicle membrane synaptic vesicle membrane SNARE complex SNARE complex assembly identical protein binding neuron projection intracellular organelle intracellular membrane-bounded organelle neuron projection terminus ion channel binding macromolecular complex binding calcium-dependent protein binding macromolecular complex assembly synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex synaptobrevin 2-SNAP-25-syntaxin-1a complex exocytic insertion of neurotransmitter receptor to postsynaptic membrane regulation of delayed rectifier potassium channel activity regulation of synaptic vesicle recycling uc007jpe.1 uc007jpe.2 uc007jpe.3 
ENSMUST00000021282.12 Pfas ENSMUST00000021282.12 phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) (from RefSeq NM_001159519.1) A4FUJ6 ENSMUST00000021282.1 ENSMUST00000021282.10 ENSMUST00000021282.11 ENSMUST00000021282.2 ENSMUST00000021282.3 ENSMUST00000021282.4 ENSMUST00000021282.5 ENSMUST00000021282.6 ENSMUST00000021282.7 ENSMUST00000021282.8 ENSMUST00000021282.9 Kiaa0361 NM_001159519 PUR4_MOUSE Q5SUR0 Q6A080 uc011xws.1 uc011xws.2 uc011xws.3 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity). Reaction=ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D- ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D- ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate; Xref=Rhea:RHEA:17129, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:147286, ChEBI:CHEBI:147287, ChEBI:CHEBI:456216; EC=6.3.5.3; Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide: step 1/2. Cytoplasm In the N-terminal section; belongs to the FGAMS family. nucleotide binding phosphoribosylformylglycinamidine synthase activity ATP binding cytoplasm purine nucleotide biosynthetic process 'de novo' IMP biosynthetic process glutamine metabolic process ribonucleoside monophosphate biosynthetic process ligase activity response to drug metal ion binding anterior head development uc011xws.1 uc011xws.2 uc011xws.3 
ENSMUST00000021283.8 Pik3r5 ENSMUST00000021283.8 phosphoinositide-3-kinase regulatory subunit 5 (from RefSeq NM_177320.2) ENSMUST00000021283.1 ENSMUST00000021283.2 ENSMUST00000021283.3 ENSMUST00000021283.4 ENSMUST00000021283.5 ENSMUST00000021283.6 ENSMUST00000021283.7 NM_177320 PI3R5_MOUSE Q3TU01 Q3UDZ2 Q5SW28 Q8C215 Q8CGQ7 uc007jno.1 uc007jno.2 uc007jno.3 Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein- mediated activation of PIK3CG (By similarity). Greatly activated by G gamma proteins. Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers (By similarity). Nucleus Cytoplasm Cell membrane ; Peripheral membrane protein Note=Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner. The heterodimerization region allows the binding to the catalytic subunit. nucleus cytoplasm microtubule organizing center cytosol plasma membrane phosphatidylinositol 3-kinase complex phosphatidylinositol 3-kinase complex, class IB G-protein coupled receptor signaling pathway phosphatidylinositol 3-kinase signaling membrane G-protein beta/gamma-subunit complex binding positive regulation of MAP kinase activity regulation of phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-3-kinase regulator activity positive regulation of protein kinase B signaling uc007jno.1 uc007jno.2 uc007jno.3 
ENSMUST00000021285.14 Stx8 ENSMUST00000021285.14 syntaxin 8, transcript variant 1 (from RefSeq NM_018768.3) ENSMUST00000021285.1 ENSMUST00000021285.10 ENSMUST00000021285.11 ENSMUST00000021285.12 ENSMUST00000021285.13 ENSMUST00000021285.2 ENSMUST00000021285.3 ENSMUST00000021285.4 ENSMUST00000021285.5 ENSMUST00000021285.6 ENSMUST00000021285.7 ENSMUST00000021285.8 ENSMUST00000021285.9 NM_018768 O88983 STX8_MOUSE uc007jnj.1 uc007jnj.2 uc007jnj.3 Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis- Golgi membranes to the ER. Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 (By similarity). Interacts with HECTD3. Interacts with TPC1 (PubMed:28855648). Membrane ; Single-pass type IV membrane protein Note=Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity). Ubiquitinated by HECTD3. Belongs to the syntaxin family. SNARE binding SNAP receptor activity lysosomal membrane endosome early endosome late endosome trans-Golgi network cytosol intracellular protein transport vesicle fusion endosome to lysosome transport endomembrane system membrane integral component of membrane vesicle-mediated transport chloride channel inhibitor activity syntaxin binding SNARE complex ubiquitin protein ligase binding late endosome membrane vesicle early endosome to late endosome transport phagocytic vesicle vesicle docking perinuclear region of cytoplasm recycling endosome cellular response to interferon-gamma regulation of protein localization to plasma membrane uc007jnj.1 uc007jnj.2 uc007jnj.3 
ENSMUST00000021287.12 Cfap52 ENSMUST00000021287.12 cilia and flagella associated protein 52 (from RefSeq NM_027963.2) CFA52_MOUSE Cfap52 ENSMUST00000021287.1 ENSMUST00000021287.10 ENSMUST00000021287.11 ENSMUST00000021287.2 ENSMUST00000021287.3 ENSMUST00000021287.4 ENSMUST00000021287.5 ENSMUST00000021287.6 ENSMUST00000021287.7 ENSMUST00000021287.8 ENSMUST00000021287.9 NM_027963 Q5F200 Q5F201 Q9D432 Q9DA68 Wdr16 uc007jnf.1 uc007jnf.2 uc007jnf.3 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (By similarity). Important for proper ciliary and flagellar beating. May act in cooperation with CFAP45 and axonemal dynein subunit DNAH11. May play a role in cell growth and/or survival (By similarity). Interacts with BRCA2 (By similarity). Interacts with the CCT chaperonin complex (By similarity). Interacts with HSP70 (By similarity). Interacts with AK8 (By similarity). Interacts with CFAP45 (By similarity). Interacts with DNAI1 (By similarity). Interacts with IQDC (By similarity). Cytoplasm Cell projection, cilium, flagellum Cytoplasm, cytoskeleton, cilium axoneme Note=Located in the proximal region of respiratory cilia. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5F201-1; Sequence=Displayed; Name=2; IsoId=Q5F201-2; Sequence=VSP_018069, VSP_018070; Belongs to the CFAP52 family. molecular_function cytoplasm cilium motile cilium cell projection uc007jnf.1 uc007jnf.2 uc007jnf.3 
ENSMUST00000021288.10 Usp43 ENSMUST00000021288.10 ubiquitin specific peptidase 43, transcript variant 1 (from RefSeq NM_173754.4) ENSMUST00000021288.1 ENSMUST00000021288.2 ENSMUST00000021288.3 ENSMUST00000021288.4 ENSMUST00000021288.5 ENSMUST00000021288.6 ENSMUST00000021288.7 ENSMUST00000021288.8 ENSMUST00000021288.9 NM_173754 Q8BUM9 Q8VDP5 UBP43_MOUSE uc007jne.1 uc007jne.2 May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BUM9-1; Sequence=Displayed; Name=2; IsoId=Q8BUM9-2; Sequence=VSP_020469, VSP_020470; Belongs to the peptidase C19 family. Sequence=AAH21474.1; Type=Erroneous initiation; Evidence=; Sequence=BAC38837.1; Type=Erroneous initiation; Evidence=; proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity uc007jne.1 uc007jne.2 
ENSMUST00000021290.2 Rcvrn ENSMUST00000021290.2 recoverin (from RefSeq NM_009038.2) ENSMUST00000021290.1 NM_009038 Q2TB46 Q2TB46_MOUSE Rcvrn uc007jmz.1 uc007jmz.2 uc007jmz.3 uc007jmz.4 Belongs to the recoverin family. calcium ion binding visual perception dendrite uc007jmz.1 uc007jmz.2 uc007jmz.3 uc007jmz.4 
ENSMUST00000021296.7 Tmem101 ENSMUST00000021296.7 transmembrane protein 101 (from RefSeq NM_029649.2) ENSMUST00000021296.1 ENSMUST00000021296.2 ENSMUST00000021296.3 ENSMUST00000021296.4 ENSMUST00000021296.5 ENSMUST00000021296.6 NM_029649 Q91VP7 Q9CZW0 TM101_MOUSE uc007lqr.1 uc007lqr.2 uc007lqr.3 uc007lqr.4 May activate NF-kappa-B signaling pathways. Membrane ; Multi-pass membrane protein cellular_component membrane integral component of membrane uc007lqr.1 uc007lqr.2 uc007lqr.3 uc007lqr.4 
ENSMUST00000021297.6 Lsm12 ENSMUST00000021297.6 LSM12 homolog (from RefSeq NM_172947.3) A2AWS3 ENSMUST00000021297.1 ENSMUST00000021297.2 ENSMUST00000021297.3 ENSMUST00000021297.4 ENSMUST00000021297.5 LSM12_MOUSE NM_172947 Q9D0R8 uc007lqs.1 uc007lqs.2 uc007lqs.3 Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein. Confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca(2+) release. Found in a complex with LSM12, TPCN1 and TPCN2. Interacts with TPCN2. Cytoplasm Note=Colocalizes with TPCN2. Belongs to the LSM12 family. Sequence=CAM16077.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM25069.1; Type=Erroneous gene model prediction; Evidence=; molecular_function cellular_component uc007lqs.1 uc007lqs.2 uc007lqs.3 
ENSMUST00000021307.10 Ccdc103 ENSMUST00000021307.10 coiled-coil domain containing 103, transcript variant 1 (from RefSeq NM_028492.3) A2AH86 CC103_MOUSE ENSMUST00000021307.1 ENSMUST00000021307.2 ENSMUST00000021307.3 ENSMUST00000021307.4 ENSMUST00000021307.5 ENSMUST00000021307.6 ENSMUST00000021307.7 ENSMUST00000021307.8 ENSMUST00000021307.9 NM_028492 Q9D9P2 uc007lst.1 uc007lst.2 uc007lst.3 Dynein-attachment factor required for cilia motility. Homodimer. Cytoplasm Cell projection, cilium, flagellum Belongs to the CCDC103/PR46b family. heart looping cilium movement epithelial cilium movement extracellular region cytoplasm cilium determination of left/right symmetry cell projection organization motile cilium outer dynein arm outer dynein arm assembly inner dynein arm assembly protein homodimerization activity cell projection axonemal dynein complex assembly determination of digestive tract left/right asymmetry uc007lst.1 uc007lst.2 uc007lst.3 
ENSMUST00000021311.10 Kif18b ENSMUST00000021311.10 kinesin family member 18B (from RefSeq NM_197959.2) ENSMUST00000021311.1 ENSMUST00000021311.2 ENSMUST00000021311.3 ENSMUST00000021311.4 ENSMUST00000021311.5 ENSMUST00000021311.6 ENSMUST00000021311.7 ENSMUST00000021311.8 ENSMUST00000021311.9 KI18B_MOUSE NM_197959 Q3U0T0 Q6PFD6 Q80V20 uc007lsy.1 uc007lsy.2 uc007lsy.3 uc007lsy.4 uc007lsy.5 In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity). Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding. Nucleus Cytoplasm Cytoplasm, cytoskeleton Note=Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindle pole during prometaphase and metaphase (By similarity). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. mitotic sister chromatid segregation nucleotide binding astral microtubule mitotic cell cycle motor activity microtubule motor activity ATP binding nucleus cytoplasm cytosol cytoskeleton kinesin complex microtubule microtubule-based movement microtubule depolymerization cell cycle microtubule binding ATP-dependent microtubule motor activity, plus-end-directed nuclear body ATPase activity kinesin binding microtubule plus-end cell division regulation of cell division mitotic spindle astral microtubule mitotic spindle midzone microtubule end uc007lsy.1 uc007lsy.2 uc007lsy.3 uc007lsy.4 uc007lsy.5 
ENSMUST00000021313.9 Dcakd ENSMUST00000021313.9 dephospho-CoA kinase domain containing, transcript variant 1 (from RefSeq NM_026551.4) DCAKD_MOUSE ENSMUST00000021313.1 ENSMUST00000021313.2 ENSMUST00000021313.3 ENSMUST00000021313.4 ENSMUST00000021313.5 ENSMUST00000021313.6 ENSMUST00000021313.7 ENSMUST00000021313.8 NM_026551 Q8BHC4 uc007ltc.1 uc007ltc.2 uc007ltc.3 Belongs to the CoaE family. nucleotide binding dephospho-CoA kinase activity ATP binding mitochondrion coenzyme A biosynthetic process phosphorylation uc007ltc.1 uc007ltc.2 uc007ltc.3 
ENSMUST00000021314.8 Nmt1 ENSMUST00000021314.8 N-myristoyltransferase 1 (from RefSeq NM_008707.4) ENSMUST00000021314.1 ENSMUST00000021314.2 ENSMUST00000021314.3 ENSMUST00000021314.4 ENSMUST00000021314.5 ENSMUST00000021314.6 ENSMUST00000021314.7 NM_008707 Nmt1 Q3UJC3 Q3UJC3_MOUSE uc007ltd.1 uc007ltd.2 uc007ltd.3 Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Reaction=N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]; Xref=Rhea:RHEA:70671, Rhea:RHEA-COMP:17947, Rhea:RHEA-COMP:17948, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:189855, ChEBI:CHEBI:189856; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70672; Evidence=; Reaction=N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]; Xref=Rhea:RHEA:15521, Rhea:RHEA- COMP:12666, Rhea:RHEA-COMP:12667, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:64723, ChEBI:CHEBI:133050; EC=2.3.1.97; Evidence= Cytoplasm, cytosol Membrane ; Peripheral membrane protein Belongs to the NMT family. glycylpeptide N-tetradecanoyltransferase activity cytoplasm cytosol plasma membrane N-terminal protein myristoylation transferase activity transferase activity, transferring acyl groups N-terminal peptidyl-glycine N-myristoylation myristoyltransferase activity extrinsic component of membrane cellular ketone metabolic process uc007ltd.1 uc007ltd.2 uc007ltd.3 
ENSMUST00000021323.11 Efcab15 ENSMUST00000021323.11 EF-hand calcium binding domain 15 (from RefSeq NM_001254724.2) 1700023F06Rik A2AB62 A2AB62_MOUSE ENSMUST00000021323.1 ENSMUST00000021323.10 ENSMUST00000021323.2 ENSMUST00000021323.3 ENSMUST00000021323.4 ENSMUST00000021323.5 ENSMUST00000021323.6 ENSMUST00000021323.7 ENSMUST00000021323.8 ENSMUST00000021323.9 Efcab15 NM_001254724 uc029roi.1 uc029roi.2 uc029roi.3 molecular_function calcium ion binding cellular_component biological_process uc029roi.1 uc029roi.2 uc029roi.3 
ENSMUST00000021324.3 Map3k14 ENSMUST00000021324.3 mitogen-activated protein kinase kinase kinase 14 (from RefSeq NM_016896.3) ENSMUST00000021324.1 ENSMUST00000021324.2 M3K14_MOUSE Map3k14 NM_016896 Nik Q9WUL6 uc007lua.1 uc007lua.2 uc007lua.3 Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non- canonical pathway. Could act in a receptor-selective manner. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Interacts with TRAF2, TRAF3, TRAF5, TRAF6, IKKA and NF-kappa- B2/P100. Interacts with PELI3. Interacts with NIBP; the interaction is direct. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with ZFP91 (By similarity). Interacts with NLRP12; this interaction promotes proteasomal degradation of MAP3K14. Directly interacts with DDX3X (By similarity). Interacts (via C-terminus and kinase domain) with PPPC3A (via N-terminus) and PPP3CB (PubMed:26029823). Cytoplasm. Phosphorylation at Thr-561 is required to activates its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization (By similarity). Autophosphorylated. Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it (By similarity). Mice display the alymphoplasia phenotype (aly), which is characterized by systemic absence of lymph nodes and Peyer patches and disorganized splenic and thymic structures with immunodeficiency. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. MAPK cascade nucleotide binding activation of MAPKK activity fibrillar center protein kinase activity protein serine/threonine kinase activity NF-kappaB-inducing kinase activity MAP kinase kinase kinase activity protein binding ATP binding nucleus cytoplasm cytosol protein phosphorylation immune response I-kappaB kinase/NF-kappaB signaling kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation activation of protein kinase activity NIK/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling intracellular membrane-bounded organelle defense response to virus cellular response to mechanical stimulus uc007lua.1 uc007lua.2 uc007lua.3 
ENSMUST00000021328.8 Lyzl6 ENSMUST00000021328.8 lysozyme-like 6, transcript variant 1 (from RefSeq NM_027083.3) ENSMUST00000021328.1 ENSMUST00000021328.2 ENSMUST00000021328.3 ENSMUST00000021328.4 ENSMUST00000021328.5 ENSMUST00000021328.6 ENSMUST00000021328.7 LYZL6_MOUSE Lyc1 NM_027083 Q9DA11 uc007lvl.1 uc007lvl.2 uc007lvl.3 uc007lvl.4 May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 (By similarity). Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17; Monomer. Secreted Cell surface Cell projection, cilium, flagellum Note=Detected in the postacrosomal area and midpiece of mature spermatozoa (PubMed:24013621). Expressed strongly in testis and epididymis and weakly in seminal vesicle, vas deferens, kidney and spleen (PubMed:24013621). Highly expressed in primary spermatocytes and round spermatids (at protein level) (PubMed:24013621). In testis expressed from day 21 during postnatal development (PubMed:24013621). In the epidydimis, first detected at day 28 and high expression is maintained until day 35. Thereafter, level declines gradually (PubMed:24013621). Belongs to the glycosyl hydrolase 22 family. lysozyme activity catalytic activity extracellular region cilium single fertilization fusion of sperm to egg plasma membrane metabolic process fertilization cell surface hydrolase activity hydrolase activity, acting on glycosyl bonds cytolysis motile cilium defense response to bacterium cell projection defense response to Gram-negative bacterium defense response to Gram-positive bacterium sperm midpiece sperm plasma membrane uc007lvl.1 uc007lvl.2 uc007lvl.3 uc007lvl.4 
ENSMUST00000021329.14 Gosr2 ENSMUST00000021329.14 golgi SNAP receptor complex member 2, transcript variant 1 (from RefSeq NM_019650.4) ENSMUST00000021329.1 ENSMUST00000021329.10 ENSMUST00000021329.11 ENSMUST00000021329.12 ENSMUST00000021329.13 ENSMUST00000021329.2 ENSMUST00000021329.3 ENSMUST00000021329.4 ENSMUST00000021329.5 ENSMUST00000021329.6 ENSMUST00000021329.7 ENSMUST00000021329.8 ENSMUST00000021329.9 GOSR2_MOUSE Gs27 NM_019650 O35166 Q3UDN0 Q9CR77 uc007lvo.1 uc007lvo.2 uc007lvo.3 uc007lvo.4 Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. Part of a unique SNARE complex composed of the Golgi SNAREs GOSR1, STX5 and YKT6. Golgi apparatus, cis-Golgi network membrane ; Single-pass type IV membrane protein Golgi apparatus membrane Endoplasmic reticulum membrane Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. Belongs to the GOSR2 family. Golgi membrane SNARE binding SNAP receptor activity endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol protein targeting to vacuole ER to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport Golgi to vacuole transport ER to Golgi transport vesicle membrane protein transport membrane integral component of membrane vesicle-mediated transport SNARE complex late endosome membrane retrograde transport, endosome to Golgi vesicle fusion with Golgi apparatus uc007lvo.1 uc007lvo.2 uc007lvo.3 uc007lvo.4 
ENSMUST00000021332.10 Fkbp3 ENSMUST00000021332.10 FK506 binding protein 3 (from RefSeq NM_013902.4) ENSMUST00000021332.1 ENSMUST00000021332.2 ENSMUST00000021332.3 ENSMUST00000021332.4 ENSMUST00000021332.5 ENSMUST00000021332.6 ENSMUST00000021332.7 ENSMUST00000021332.8 ENSMUST00000021332.9 FKBP3_MOUSE Fkbp25 NM_013902 Q62446 Q9WTJ7 uc007nrb.1 uc007nrb.2 uc007nrb.3 FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins (By similarity). Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Inhibited preferentially by rapamycin over FK506. Q62446; Q00987: MDM2; Xeno; NbExp=4; IntAct=EBI-8313562, EBI-389668; Nucleus Belongs to the FKBP-type PPIase family. protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity protein binding nucleus isomerase activity uc007nrb.1 uc007nrb.2 uc007nrb.3 
ENSMUST00000021335.7 Scfd1 ENSMUST00000021335.7 Sec1 family domain containing 1, transcript variant 3 (from RefSeq NR_157117.1) ENSMUST00000021335.1 ENSMUST00000021335.2 ENSMUST00000021335.3 ENSMUST00000021335.4 ENSMUST00000021335.5 ENSMUST00000021335.6 NR_157117 Q8BRF7 Q8BRZ2 Q8K179 Q9CXR8 SCFD1_MOUSE Stxbp1l2 uc007nmq.1 uc007nmq.2 uc007nmq.3 uc007nmq.4 Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). Interacts with STX17. Interacts with STX5A. Interacts with the COG complex via COG4 (By similarity). Cytoplasm Endoplasmic reticulum membrane ; Peripheral membrane protein Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BRF7-1; Sequence=Displayed; Name=2; IsoId=Q8BRF7-2; Sequence=VSP_011310, VSP_011311; Name=3; IsoId=Q8BRF7-3; Sequence=VSP_011312, VSP_011313; Belongs to the STXBP/unc-18/SEC1 family. Sequence=AAH27793.1; Type=Erroneous initiation; Evidence=; cell morphogenesis response to hypoxia cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus Golgi-associated vesicle cis-Golgi network plasma membrane retrograde vesicle-mediated transport, Golgi to ER post-Golgi vesicle-mediated transport vesicle docking involved in exocytosis response to toxic substance protein transport membrane vesicle-mediated transport syntaxin binding Golgi cisterna membrane macromolecular complex binding protein N-terminus binding regulation of protein transport regulation of ER to Golgi vesicle-mediated transport toxin transport negative regulation of autophagosome assembly uc007nmq.1 uc007nmq.2 uc007nmq.3 uc007nmq.4 
ENSMUST00000021338.10 Ap4s1 ENSMUST00000021338.10 adaptor-related protein complex AP-4, sigma 1, transcript variant 2 (from RefSeq NM_021710.4) AP4S1_MOUSE Ap4s1 ENSMUST00000021338.1 ENSMUST00000021338.2 ENSMUST00000021338.3 ENSMUST00000021338.4 ENSMUST00000021338.5 ENSMUST00000021338.6 ENSMUST00000021338.7 ENSMUST00000021338.8 ENSMUST00000021338.9 NM_021710 Q9WVL1 uc007nmv.1 uc007nmv.2 uc007nmv.3 uc007nmv.4 This gene encodes the sigma subunit of the adaptor-related protein complex 4 which mediates intracellular membrane trafficking along the endocytic and secretory transport pathways. This complex contains four subunits, beta, epsilon, mu, and sigma, and belongs to a family of five adapter protein complexes, including three clathrin-associated complexes and two non clathrin-associated complexes, that localize to different intracellular compartments and mediate membrane vesicle trafficking using distinct pathways. In humans, loss-of-function mutations in this gene have been linked to specific adapter complex 4 deficiency disorders including hereditary spastic paraplegia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]. Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal. Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1). Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Belongs to the adaptor complexes small subunit family. Golgi apparatus trans-Golgi network intracellular protein transport protein transport membrane vesicle-mediated transport AP-4 adaptor complex intracellular membrane-bounded organelle uc007nmv.1 uc007nmv.2 uc007nmv.3 uc007nmv.4 
ENSMUST00000021339.8 Dtd2 ENSMUST00000021339.8 D-tyrosyl-tRNA deacylase 2, transcript variant 2 (from RefSeq NM_029545.3) DTD2_MOUSE ENSMUST00000021339.1 ENSMUST00000021339.2 ENSMUST00000021339.3 ENSMUST00000021339.4 ENSMUST00000021339.5 ENSMUST00000021339.6 ENSMUST00000021339.7 NM_029545 Q8BHA3 Q9D363 Q9D4Q5 uc007nne.1 uc007nne.2 Deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids. Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS. Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site. Also hydrolyzes correctly charged, achiral, glycyl- tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation. Reaction=a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+); Xref=Rhea:RHEA:13953, Rhea:RHEA-COMP:10123, Rhea:RHEA- COMP:10124, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:59871, ChEBI:CHEBI:78442, ChEBI:CHEBI:79333; EC=3.1.1.96; Evidence=; Reaction=glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala); Xref=Rhea:RHEA:53744, Rhea:RHEA-COMP:9657, Rhea:RHEA-COMP:13640, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305, ChEBI:CHEBI:78442, ChEBI:CHEBI:78522; EC=3.1.1.96; Evidence=; Reaction=D-tyrosyl-tRNA(Tyr) + H2O = D-tyrosine + tRNA(Tyr); Xref=Rhea:RHEA:25347, Rhea:RHEA-COMP:9707, Rhea:RHEA-COMP:9872, ChEBI:CHEBI:15377, ChEBI:CHEBI:58570, ChEBI:CHEBI:78442, ChEBI:CHEBI:78723; Evidence=; Reaction=H2O + L-alanyl-tRNA(Thr) = H(+) + L-alanine + tRNA(Thr); Xref=Rhea:RHEA:17793, Rhea:RHEA-COMP:9670, Rhea:RHEA-COMP:14576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57972, ChEBI:CHEBI:78442, ChEBI:CHEBI:78497; Evidence=; Homodimer. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BHA3-1; Sequence=Displayed; Name=2; IsoId=Q8BHA3-2; Sequence=VSP_021174; A Gly-transPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of most L-amino acids except L-Ala. The trans conformation of the motif is maintained by Arg-151. Belongs to the DTD family. Sequence=BAB31157.1; Type=Frameshift; Evidence=; tRNA binding aminoacyl-tRNA editing activity RNA binding cytoplasm tRNA metabolic process hydrolase activity D-aminoacyl-tRNA deacylase activity D-tyrosyl-tRNA(Tyr) deacylase activity uc007nne.1 uc007nne.2 
ENSMUST00000021345.14 Gtf2a1 ENSMUST00000021345.14 general transcription factor II A, 1, transcript variant 1 (from RefSeq NM_031391.2) ENSMUST00000021345.1 ENSMUST00000021345.10 ENSMUST00000021345.11 ENSMUST00000021345.12 ENSMUST00000021345.13 ENSMUST00000021345.2 ENSMUST00000021345.3 ENSMUST00000021345.4 ENSMUST00000021345.5 ENSMUST00000021345.6 ENSMUST00000021345.7 ENSMUST00000021345.8 ENSMUST00000021345.9 NM_031391 Q8C812 Q99PM3 TF2AA_MOUSE uc007okr.1 uc007okr.2 uc007okr.3 uc007okr.4 TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity). TFIIA is a heterodimer of a unprocessed large subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha, a beta and a gamma subunit. TFIIA forms a complex with TBP (By similarity). Nucleus Expressed in pachytene spermatocytes and spermatids. Up-regulated during germ cell differentiation in testis. The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteasomal degradation (By similarity). Belongs to the TFIIA subunit 1 family. Sequence=BAC33430.1; Type=Erroneous initiation; Evidence=; RNA polymerase II repressing transcription factor binding DNA binding protein binding nucleus nucleoplasm transcription factor TFIID complex transcription factor TFIIA complex cytoplasm cytosol transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter transcription factor binding obsolete general RNA polymerase II transcription factor activity TBP-class protein binding protein heterodimerization activity uc007okr.1 uc007okr.2 uc007okr.3 uc007okr.4 
ENSMUST00000021346.14 Tshr ENSMUST00000021346.14 thyroid stimulating hormone receptor, transcript variant 1 (from RefSeq NM_011648.5) ENSMUST00000021346.1 ENSMUST00000021346.10 ENSMUST00000021346.11 ENSMUST00000021346.12 ENSMUST00000021346.13 ENSMUST00000021346.2 ENSMUST00000021346.3 ENSMUST00000021346.4 ENSMUST00000021346.5 ENSMUST00000021346.6 ENSMUST00000021346.7 ENSMUST00000021346.8 ENSMUST00000021346.9 NM_011648 P47750 Q562E4 Q9D697 TSHR_MOUSE uc007okq.1 uc007okq.2 uc007okq.3 uc007okq.4 Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Interacts with heterodimer GPHA2:GPHB5; this interaction stimulates cAMP production. Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function. Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Glycosylated. Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation. Note=Defects in Tshr are the cause of hyt/hyt hypothyroidism, an autosomal recessive, fetal-onset, severe hypothyroidism related to TSH hyporesponsiveness and associated with elevated TSH. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. G-protein coupled receptor activity thyroid-stimulating hormone receptor activity plasma membrane integral component of plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity positive regulation of cell proliferation adult locomotory behavior G-protein coupled peptide receptor activity hormone-mediated signaling pathway membrane integral component of membrane basolateral plasma membrane protein-hormone receptor activity B cell differentiation signaling receptor activity thyroid-stimulating hormone signaling pathway regulation of locomotion positive regulation of multicellular organism growth receptor complex macromolecular complex binding membrane raft inner ear receptor cell development inner ear receptor stereocilium organization dopaminergic neuron differentiation cochlea morphogenesis cellular response to glycoprotein cellular response to thyrotropin-releasing hormone uc007okq.1 uc007okq.2 uc007okq.3 uc007okq.4 
ENSMUST00000021347.12 Sel1l ENSMUST00000021347.12 sel-1 suppressor of lin-12-like (C. elegans), transcript variant 1 (from RefSeq NM_001039089.1) ENSMUST00000021347.1 ENSMUST00000021347.10 ENSMUST00000021347.11 ENSMUST00000021347.2 ENSMUST00000021347.3 ENSMUST00000021347.4 ENSMUST00000021347.5 ENSMUST00000021347.6 ENSMUST00000021347.7 ENSMUST00000021347.8 ENSMUST00000021347.9 NM_001039089 Q9DBD8 Q9Z2G6 SE1L1_MOUSE Sel1h uc007oky.1 uc007oky.2 Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:25066055, PubMed:24453213). Enhances SYVN1 stability (PubMed:24453213). Plays a role in LPL maturation and secretion (PubMed:25066055). Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells (PubMed:20170518, PubMed:24453213). May play a role in Notch signaling (PubMed:20170518). Homodimer and homooligomer (PubMed:27064360). May form a complex with ERLEC1, HSPA5, OS9, and SYVN1 (By similarity). Interacts with FOXRED2 and EDEM1 (By similarity). Interacts with LPL and LMF1; may stabilize the complex formed by LPL and LMF1 and thereby promote the export of LPL dimers (PubMed:25066055). Component of the HRD1 complex, which comprises at least SYNV1/HRD1, DERL1/2, FAM8A1, HERPUD1/HERP, OS9, SEL1L and UBE2J1 (By similarity). SYNV1 assembles with SEL1L and FAM8A1 through its transmembrane domains, but interaction with its cytoplasmic domain is required to confer stability to FAM8A1 and enhance recruitment of HERPUD1 (By similarity). The interaction with SYNV1/HRD1 is direct (PubMed:25066055, PubMed:27064360). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z2G6-1; Sequence=Displayed; Name=2; IsoId=Q9Z2G6-2; Sequence=VSP_004384; Highly expressed in pancreas, white adipose tissue, liver and spleen (at protein level) (PubMed:25066055, PubMed:24453213). Detected in heart, brain, spleen, lung, liver, kidney and testis (PubMed:9858735). First detected at 12.5 dpc in a small number of pancreas epithelial cells. Highly expressed in embryonic pancreas epithelium at later stages of embryonic development. N-glycosylated. Taxomifen-inducible gene disruption in adult mice leads to premature death within 3 weeks after the onset of taxomifen treatment. Mice progressively loose weight and become moribund despite increased food intake and normal blood glucose levels, suggesting nutrient maladsorption. After eight days of treatment, the pancreas was diffusely dark red and soft, suggesting severe pancreas atrophy. Still, the endocrine parts of the pancreas were not affected. Pancreas weight was about half of that of wild-type, the size of secretory zymogen granules was reduced and pancreatic lipase and alpha-amylase levels were strongly reduced. Besides, the morphology of the endoplasmic reticulum in pancreas acinar cells was abnormal, with swollen and fragmented cisternae. Likewise, SYVN1 protein levels are decreased, while those of other ERAD markers are increased (PubMed:24453213). Adipocyte-specific gene disruption does not give rise to any obvious phenotype when mice are kept on a low-fat diet. Mutant mice are resistant to diet-induced obesity when kept on a high-fat diet, in spite of normal food intake and physical activity. Mutant mice show dramatically reduced accumulation of fat mass relative to wild-type, while lean mass is not affected. Intriguingly, mutant mice display enlarged livers that develop steatosis and increased triglyceride levels. Mutant mice display increased fasting serum triglyceride and insulin levels. Likewise, mutant mice display hypertriglyceridemia after feeding, especially on a high-fat diet. In spite of increased cellular LPL levels, LPL secretion is reduced by 80 to 90% (PubMed:25066055). Gene disruption after residue 465 and replacement of the C-terminus with a beta-galactosidase-neomycin reporter gene construct leads to complete embryonic lethality; most die before 13.5 dpc. Only 5% of the embryos are viable at 15.5 dpc. Mutant embryos display defects in the differentiation of the pancreas epithelium. The defects in pancreas differentiation can be alleviated by pharmacological inhibition of Notch signaling (in vitro). Belongs to the sel-1 family. Hrd1p ubiquitin ligase ERAD-L complex protein binding endoplasmic reticulum endoplasmic reticulum membrane triglyceride metabolic process Notch signaling pathway protein secretion membrane integral component of membrane protein ubiquitination ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol response to endoplasmic reticulum stress ERAD pathway Derlin-1 retrotranslocation complex ubiquitin-protein transferase activity uc007oky.1 uc007oky.2 
ENSMUST00000021356.6 Dnaaf2 ENSMUST00000021356.6 dynein, axonemal assembly factor 2 (from RefSeq NM_027269.4) Dnaaf2 ENSMUST00000021356.1 ENSMUST00000021356.2 ENSMUST00000021356.3 ENSMUST00000021356.4 ENSMUST00000021356.5 KTU_MOUSE Ktu NM_027269 Q3T9I8 Q3U4G5 Q6P5G9 Q8BPI1 Q9CZC7 uc007nrt.1 uc007nrt.2 uc007nrt.3 This gene encodes a highly conserved protein involved in the preassembly of dynein arm complexes which power cilia. These complexes are found in some cilia and are assembled in the cytoplasm prior to transport for cilia formation. Mutations in the human gene have been associated with primary ciliary dyskinesia. [provided by RefSeq, Sep 2015]. ##Evidence-Data-START## Transcript exon combination :: BC055807.1, AB455811.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. Interacts with DNAI2 and HSPA1A (PubMed:19052621). Interacts with CFAP300. Interacts with DNAAF4. Interacts with DNAAF6/PIH1D3 (By similarity). Q8BPI1; A2AC93: Dnai2; NbExp=2; IntAct=EBI-15744709, EBI-15744757; Cytoplasm Dynein axonemal particle Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BPI1-1; Sequence=Displayed; Name=2; IsoId=Q8BPI1-2; Sequence=VSP_036538; Expressed in nearly all organs of adult, with higher expression in tissues known to have motile cilia and flagella, such as brain and testis. Belongs to the PIH1 family. Kintoun subfamily. Sequence=AAH58344.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB28455.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC35879.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE32466.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE43032.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding cytoplasm cytosol response to organic substance response to retinoic acid ciliary basal body cilium-dependent cell motility axonemal dynein complex assembly uc007nrt.1 uc007nrt.2 uc007nrt.3 
ENSMUST00000021359.7 Pole2 ENSMUST00000021359.7 polymerase (DNA directed), epsilon 2 (p59 subunit) (from RefSeq NM_011133.2) DPOE2_MOUSE ENSMUST00000021359.1 ENSMUST00000021359.2 ENSMUST00000021359.3 ENSMUST00000021359.4 ENSMUST00000021359.5 ENSMUST00000021359.6 NM_011133 O54956 Q6P3Y7 Q8BP72 uc007nrv.1 uc007nrv.2 uc007nrv.3 Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4. Nucleus. In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis. Belongs to the DNA polymerase epsilon subunit B family. DNA binding DNA-directed DNA polymerase activity nucleus nucleoplasm DNA replication DNA-dependent DNA replication epsilon DNA polymerase complex nuclear body transferase activity nucleotidyltransferase activity error-prone translesion synthesis intracellular membrane-bounded organelle uc007nrv.1 uc007nrv.2 uc007nrv.3 
ENSMUST00000021362.5 Klhdc2 ENSMUST00000021362.5 kelch domain containing 2 (from RefSeq NM_027117.3) E9QKN6 ENSMUST00000021362.1 ENSMUST00000021362.2 ENSMUST00000021362.3 ENSMUST00000021362.4 KLDC2_MOUSE Klhdc2 NM_027117 Q4G5Y1 Q99JY2 Q9D784 uc007nsa.1 uc007nsa.2 uc007nsa.3 uc007nsa.4 Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation. The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine. The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation. May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding. Protein modification; protein ubiquitination. Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter KLHDC2. Interacts with CREB3; interaction is direct and specific as it does not interact with CREB1, ATF4, ATF6, JUN, FOS, CEBPA or herpes simplex virus transactivator VP16. Nucleus protein binding nucleus biological_process nuclear body nuclear membrane uc007nsa.1 uc007nsa.2 uc007nsa.3 uc007nsa.4 
ENSMUST00000021368.10 Nemf ENSMUST00000021368.10 nuclear export mediator factor (from RefSeq NM_025441.3) ENSMUST00000021368.1 ENSMUST00000021368.2 ENSMUST00000021368.3 ENSMUST00000021368.4 ENSMUST00000021368.5 ENSMUST00000021368.6 ENSMUST00000021368.7 ENSMUST00000021368.8 ENSMUST00000021368.9 NEMF_MOUSE NM_025441 Nemf Q3TAS9 Q3UF46 Q66JX6 Q8C9R6 Q8CA65 Q8CCP0 Q8JZT9 Q8R072 Q9CW30 Q9CYB8 Q9D4A9 uc007nse.1 uc007nse.2 uc007nse.3 uc007nse.4 Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:33406423). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:33406423). Within the RQC complex, NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of LTN1 to stalled 60S subunits (By similarity). Following binding to stalled 60S ribosomal subunits, NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (PubMed:33406423). Mainly recruits alanine- charged tRNAs, but can also other amino acid-charged tRNAs (By similarity). CAT tailing is required to promote ubiquitination of stalled nascent chains by different E3 ubiquitin-protein ligases (By similarity). In the canonical RQC pathway (RQC-L), CAT tailing facilitates LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (By similarity). In the alternative RQC pathway (RQC-C) CAT tailing creates an C-degron mainly composed of alanine that is recognized by the CRL2(KLHDC10) and RCHY1/PIRH2 E3 ligases, leading to ubiquitination and degradation of stalled nascent chains (By similarity). NEMF may also indirectly play a role in nuclear export (By similarity). Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase LTN1, TCF25 and NEMF associated with the 60S ribosomal subunit (By similarity). The complex probably also contains VCP/p97 and its ubiquitin-binding cofactors (By similarity). Interacts (via its N-terminus) with XPO1 (By similarity). Cytoplasm, cytosol Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8CCP0-1; Sequence=Displayed; Name=2; IsoId=Q8CCP0-2; Sequence=VSP_008397, VSP_008398; Name=3; IsoId=Q8CCP0-3; Sequence=VSP_010465, VSP_010466; Name=4; IsoId=Q8CCP0-4; Sequence=VSP_010463, VSP_010464; [Isoform 2]: Due to intron retention. Belongs to the NEMF family. Sequence=AAH27272.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH53488.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH53488.2; Type=Frameshift; Evidence=; Sequence=BAB30366.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB30366.1; Type=Frameshift; Evidence=; Sequence=BAC27849.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC27849.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; tRNA binding nucleus ribosomal large subunit binding nuclear export rescue of stalled ribosome RQC complex ribosome-associated ubiquitin-dependent protein catabolic process uc007nse.1 uc007nse.2 uc007nse.3 uc007nse.4 
ENSMUST00000021370.10 L2hgdh ENSMUST00000021370.10 L-2-hydroxyglutarate dehydrogenase (from RefSeq NM_145443.2) ENSMUST00000021370.1 ENSMUST00000021370.2 ENSMUST00000021370.3 ENSMUST00000021370.4 ENSMUST00000021370.5 ENSMUST00000021370.6 ENSMUST00000021370.7 ENSMUST00000021370.8 ENSMUST00000021370.9 L2HDH_MOUSE NM_145443 Q3TH61 Q3U7Z0 Q3ULY6 Q91YP0 uc011ynb.1 uc011ynb.2 uc011ynb.3 Reaction=(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2; Xref=Rhea:RHEA:21252, ChEBI:CHEBI:13193, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:17499; EC=1.1.99.2; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Mitochondrion Belongs to the L2HGDH family. (S)-2-hydroxy-acid oxidase activity mitochondrion integral component of membrane oxidoreductase activity cellular protein metabolic process 2-hydroxyglutarate dehydrogenase activity oxidation-reduction process uc011ynb.1 uc011ynb.2 uc011ynb.3 
ENSMUST00000021375.12 Sec23a ENSMUST00000021375.12 SEC23 homolog A, COPII coat complex component, transcript variant 1 (from RefSeq NM_009147.2) ENSMUST00000021375.1 ENSMUST00000021375.10 ENSMUST00000021375.11 ENSMUST00000021375.2 ENSMUST00000021375.3 ENSMUST00000021375.4 ENSMUST00000021375.5 ENSMUST00000021375.6 ENSMUST00000021375.7 ENSMUST00000021375.8 ENSMUST00000021375.9 NM_009147 Q01405 Q8JZL4 SC23A_MOUSE Sec23 Sec23a Sec23r uc007npw.1 uc007npw.2 uc007npw.3 Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (By similarity). Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (PubMed:27354378). COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (By similarity). Interacts with SEC23IP (PubMed:10400679). Interacts with HTR4 (PubMed:15466885). Interacts with SEC16A (PubMed:17428803). Interacts with SLC6A4 (PubMed:17452640). Interacts (as part of the Sec23/24 complex) with SEC22B; recruits SEC22B into COPII-coated vesicles and allows the transport of this cargo from the endoplasmic reticulum to the Golgi. Interacts (via Gelsolin-like repeat) with MIA2 and MIA3; specifically involved in the transport of large cargos like the collagen COL7A1 (By similarity). Interacts with DDHD1 (PubMed:17428803). Interacts with TMEM39A (By similarity). Interacts with SACM1L; this interaction is reduced in the absence of TMEM39A (By similarity). Interacts with kinase FAM20C; transport of FAM20C from the endoplasmic reticulum to the Golgi is likely to be mediated by COPII vesicles (By similarity). Q01405; Q9NR31: SAR1A; Xeno; NbExp=2; IntAct=EBI-775901, EBI-3920694; Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytosol Note=Enriched at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). High levels in brain and fibroblasts. The Gelsolin-like repeat mediates interaction with proteins containing PPP motifs that include MIA2, MIA3 but also SEC31A. These interactions are probably competitive. Belongs to the SEC23/SEC24 family. SEC23 subfamily. Sequence=BAA02209.1; Type=Frameshift; Evidence=; Golgi membrane GTPase activator activity protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol intracellular protein transport ER to Golgi vesicle-mediated transport zinc ion binding ER to Golgi transport vesicle membrane protein transport membrane vesicle-mediated transport extrinsic component of membrane COPII vesicle coat ER to Golgi transport vesicle cytoplasmic vesicle positive regulation of GTPase activity metal ion binding perinuclear region of cytoplasm endoplasmic reticulum exit site protein localization to plasma membrane cargo loading into COPII-coated vesicle COPII-coated vesicle budding uc007npw.1 uc007npw.2 uc007npw.3 
ENSMUST00000021377.5 Cdkl1 ENSMUST00000021377.5 cyclin dependent kinase like 1 (from RefSeq NM_183294.2) CDKL1_MOUSE Cdkl1 ENSMUST00000021377.1 ENSMUST00000021377.2 ENSMUST00000021377.3 ENSMUST00000021377.4 NM_183294 Q8CEQ0 uc007nst.1 uc007nst.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Cytoplasm Nucleus The [NKR]KIAxRE motif seems to be a cyclin-binding region. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus nucleoplasm cytoplasm protein phosphorylation heart development kinase activity phosphorylation transferase activity ciliary transition zone intracellular membrane-bounded organelle regulation of cell cycle regulation of cilium assembly uc007nst.1 uc007nst.2 
ENSMUST00000021379.8 Gemin2 ENSMUST00000021379.8 gem nuclear organelle associated protein 2 (from RefSeq NM_025656.5) ENSMUST00000021379.1 ENSMUST00000021379.2 ENSMUST00000021379.3 ENSMUST00000021379.4 ENSMUST00000021379.5 ENSMUST00000021379.6 ENSMUST00000021379.7 GEMI2_MOUSE Gemin2 NM_025656 Q9CQQ4 Q9DAD7 Sip1 uc007npx.1 uc007npx.2 uc007npx.3 uc007npx.4 uc007npx.5 This gene encodes one of the proteins found in the survival of motor neuron (SMN) complex, which consists of the SMN protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal small nuclear ribonucleoproteins (snRNP) and for pre-mRNA splicing. This protein interacts directly with the SMN protein and it is required for formation of the SMN complex. Disruption of this gene in mouse resulted in impaired snRNP assembly, and motor neuron degeneration. [provided by RefSeq, Sep 2015]. ##Evidence-Data-START## Transcript exon combination :: AK005928.1, AK013414.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre- mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (By similarity). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (By similarity). Monomer (By similarity). Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG (By similarity). Interacts with GEMIN5; the interaction is direct (By similarity). Interacts (via C-terminus) with SMN1; the interaction is direct (By similarity). Interacts with SNRPD1; the interaction is direct (By similarity). Interacts with SNRPD2; the interaction is direct (By similarity). Interacts (via N- terminus) with SNRPF; the interaction is direct (By similarity). Interacts (via N-terminus) with SNRPE; the interaction is direct (By similarity). Interacts (via N-terminus) with SNRPG; the interaction is direct (By similarity). Nucleus, gem Cytoplasm Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm (By similarity). Belongs to the gemin-2 family. spliceosomal complex assembly spliceosomal snRNP assembly nucleus spliceosomal complex nucleolus cytoplasm cytosol mRNA processing RNA splicing nuclear body SMN complex SMN-Sm protein complex Gemini of coiled bodies uc007npx.1 uc007npx.2 uc007npx.3 uc007npx.4 uc007npx.5 
ENSMUST00000021380.10 Trappc6b ENSMUST00000021380.10 trafficking protein particle complex 6B, transcript variant 1 (from RefSeq NM_030057.3) ENSMUST00000021380.1 ENSMUST00000021380.2 ENSMUST00000021380.3 ENSMUST00000021380.4 ENSMUST00000021380.5 ENSMUST00000021380.6 ENSMUST00000021380.7 ENSMUST00000021380.8 ENSMUST00000021380.9 NM_030057 Q9D289 TPC6B_MOUSE Trappc6b uc007npy.1 uc007npy.2 uc007npy.3 uc007npy.4 Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (By similarity). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (By similarity). Homodimer (By similarity). Part of a TRAPP complex. Heterodimer with TRAPPC3 (By similarity). The heterodimer TRAPPC6B- TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation (By similarity). Golgi apparatus, cis-Golgi network Endoplasmic reticulum Widely expressed. Expressed in lung, heart, liver, spleen, brain and kidney. Belongs to the TRAPP small subunits family. BET3 subfamily. molecular_function endoplasmic reticulum Golgi apparatus cis-Golgi network trans-Golgi network ER to Golgi vesicle-mediated transport nervous system development regulation of GTPase activity Golgi vesicle transport uc007npy.1 uc007npy.2 uc007npy.3 uc007npy.4 
ENSMUST00000021381.6 Pnn ENSMUST00000021381.6 pinin (from RefSeq NM_008891.2) ENSMUST00000021381.1 ENSMUST00000021381.2 ENSMUST00000021381.3 ENSMUST00000021381.4 ENSMUST00000021381.5 NM_008891 Pnn Q3TUQ5 Q3TUQ5_MOUSE uc007nqb.1 uc007nqb.2 uc007nqb.3 Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex. Cell junction, desmosome Nucleus speckle Belongs to the pinin family. nuclear speck exon-exon junction complex catalytic step 2 spliceosome uc007nqb.1 uc007nqb.2 uc007nqb.3 
ENSMUST00000021390.9 Galc ENSMUST00000021390.9 galactosylceramidase (from RefSeq NM_008079.4) ENSMUST00000021390.1 ENSMUST00000021390.2 ENSMUST00000021390.3 ENSMUST00000021390.4 ENSMUST00000021390.5 ENSMUST00000021390.6 ENSMUST00000021390.7 ENSMUST00000021390.8 GALC_MOUSE Galc NM_008079 O35151 P54818 Q3U3H7 uc007olf.1 uc007olf.2 uc007olf.3 uc007olf.4 This gene encodes galactosylceramidase, the lysosomal hydryolase involved in the catabolism of galactosylceramide. Mutations in this gene result in slow growth, tremors and hind leg weakness, collectively termed as the 'twitcher' phenotype. In humans, deficiency of this gene product causes a lysosomal storage disorder known as Krabbe disease. [provided by RefSeq, Dec 2014]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC086671.1, AK154760.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine (PubMed:8769874, PubMed:10861297). Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity). Reaction=a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose; Xref=Rhea:RHEA:14297, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377, ChEBI:CHEBI:18390, ChEBI:CHEBI:52639; EC=3.2.1.46; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14298; Evidence=; Reaction=a D-galactosylceramide + H2O = an N-acyl-sphingoid base + D- galactose; Xref=Rhea:RHEA:43412, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377, ChEBI:CHEBI:36498, ChEBI:CHEBI:83273; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43413; Evidence=; Reaction=beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O = D-galactose + sphing-4-enine; Xref=Rhea:RHEA:43908, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377, ChEBI:CHEBI:57756, ChEBI:CHEBI:57934; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43909; Evidence=; Lysosome Detected in brain and kidney. Note=Defects in Galc are the cause of the 'twitcher' phenotype; an autosomal recessive leukodystrophy similar to the human disease (Krabbe disease). This deficiency results in the insufficient catabolism of several galactolipids that are important in the production of normal myelin. Belongs to the glycosyl hydrolase 59 family. It is uncertain whether Met-1 or Met-17 is the initiator. Sequence=AAB71823.1; Type=Erroneous initiation; Evidence=; Sequence=AAH86671.1; Type=Erroneous initiation; Evidence=; Sequence=BAA07560.1; Type=Erroneous initiation; Evidence=; catalytic activity galactosylceramidase activity mitochondrion lysosome lipid metabolic process sphingolipid metabolic process galactosylceramide catabolic process metabolic process lipid catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds myelination uc007olf.1 uc007olf.2 uc007olf.3 uc007olf.4 
ENSMUST00000021405.8 Polr2h ENSMUST00000021405.8 polymerase (RNA) II (DNA directed) polypeptide H, transcript variant 6 (from RefSeq NR_184435.1) ENSMUST00000021405.1 ENSMUST00000021405.2 ENSMUST00000021405.3 ENSMUST00000021405.4 ENSMUST00000021405.5 ENSMUST00000021405.6 ENSMUST00000021405.7 NR_184435 Q3TT30 Q923G2 RPAB3_MOUSE uc007yqz.1 uc007yqz.2 uc007yqz.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. Directly interacts with POLR2A. The transcriptionally active RNA Pol III complex consists of a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4- POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Nucleus Belongs to the eukaryotic RPB8 RNA polymerase subunit family. DNA binding single-stranded DNA binding DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm DNA-directed RNA polymerase II, core complex DNA-directed RNA polymerase III complex nucleolus DNA-directed RNA polymerase I complex transcription, DNA-templated transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter transcription from RNA polymerase III promoter protein-DNA complex RNA polymerase I activity RNA polymerase II activity RNA polymerase III activity uc007yqz.1 uc007yqz.2 uc007yqz.3 
ENSMUST00000021406.6 2700097O09Rik ENSMUST00000021406.6 RIKEN cDNA 2700097O09 gene, transcript variant 3 (from RefSeq NR_155260.1) 2700097O09Rik ENSMUST00000021406.1 ENSMUST00000021406.2 ENSMUST00000021406.3 ENSMUST00000021406.4 ENSMUST00000021406.5 NR_155260 Q6PGK3 Q6PGK3_MOUSE uc007nod.1 uc007nod.2 uc007nod.1 uc007nod.2 
ENSMUST00000021410.10 Ppp2r3c ENSMUST00000021410.10 protein phosphatase 2, regulatory subunit B'', gamma, transcript variant 5 (from RefSeq NR_168552.1) B2RR97 ENSMUST00000021410.1 ENSMUST00000021410.2 ENSMUST00000021410.3 ENSMUST00000021410.4 ENSMUST00000021410.5 ENSMUST00000021410.6 ENSMUST00000021410.7 ENSMUST00000021410.8 ENSMUST00000021410.9 G5pr MNCb-1932 NR_168552 P2R3C_MOUSE Q9CSA6 Q9JJD2 Q9JK24 uc007nom.1 uc007nom.2 uc007nom.3 May regulate MCM3AP phosphorylation through phosphatase recruitment (PubMed:12167160). May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex (By similarity). May play a role in the activation-induced cell death of B-cells (PubMed:16129705, PubMed:16343422). Interacts with MCM3AP/GANP, PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1. Nucleus Cytoplasm Note=Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. Expressed in all tissues tested including heart, brain, spleen, thymus, lung, liver, kidney and testis. Detected from 6 to 12 dpc in whole embryos and from 14 to 18 dpc in the heads of the embryos. Expressed in central nervous system, spine, face, pharynx, limbs and viscera at 11 dpc. Up-regulated upon B-cell receptor cross-linking. Mice display a reduction in the number of mature B-cells and an impaired B-cell proliferation upon B-Cell receptor cross-linking probably due to a loss of inhibition of BCR-induced apoptosis. PPP2R3C overexpression protects B-cells from activation- induced cell death. microtubule cytoskeleton organization B cell homeostasis regulation of antimicrobial humoral response protein binding nucleus cytoplasm Golgi apparatus centrosome spindle cytosol cortical cytoskeleton organization activation of protein kinase activity regulation of dephosphorylation T cell homeostasis positive regulation of B cell differentiation metal ion binding spleen development regulation of B cell activation regulation of mitochondrial depolarization uc007nom.1 uc007nom.2 uc007nom.3 
ENSMUST00000021411.15 Prorp ENSMUST00000021411.15 protein only RNase P catalytic subunit (from RefSeq NM_025373.1) ENSMUST00000021411.1 ENSMUST00000021411.10 ENSMUST00000021411.11 ENSMUST00000021411.12 ENSMUST00000021411.13 ENSMUST00000021411.14 ENSMUST00000021411.2 ENSMUST00000021411.3 ENSMUST00000021411.4 ENSMUST00000021411.5 ENSMUST00000021411.6 ENSMUST00000021411.7 ENSMUST00000021411.8 ENSMUST00000021411.9 Kiaa0391 MRPP3_MOUSE Mrpp3 NM_025373 Q6A076 Q8BSN8 Q8JZY4 Q9CTH1 Q9D7W9 uc007nop.1 uc007nop.2 uc007nop.3 uc007nop.4 Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends. Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.; EC=3.1.26.5; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 Mg(2+) or Mg(2+) ions per subunit. ; Catalytic component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3. Mitochondrion Detected, after the onset of hearing, in the organ of Corti around the afferent and efferent synapses of the inner hair cells and the efferent synapses of the outer hair cells. Displays a distorted and non-productive active site that probably switches to a fully productive state only upon association with TRMT10C/MRPP1, HSD17B10/MRPP2 and pre-tRNA substrate. Degraded by LONP1 following mitochondrial unfolded protein response, probably leading to inhibit translation in mitochondrion. Belongs to the PPR family. P subfamily. Sequence=BAB25874.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32220.1; Type=Miscellaneous discrepancy; Note=Partial sequence.; Evidence=; tRNA 5'-leader removal nuclease activity ribonuclease P activity nucleus mitochondrion tRNA processing hydrolase activity mitochondrial ribonuclease P complex mitochondrial nucleoid metal ion binding nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic mitochondrial tRNA 5'-end processing uc007nop.1 uc007nop.2 uc007nop.3 uc007nop.4 
ENSMUST00000021412.9 Psma6 ENSMUST00000021412.9 proteasome subunit alpha 6, transcript variant 1 (from RefSeq NM_011968.3) ENSMUST00000021412.1 ENSMUST00000021412.2 ENSMUST00000021412.3 ENSMUST00000021412.4 ENSMUST00000021412.5 ENSMUST00000021412.6 ENSMUST00000021412.7 ENSMUST00000021412.8 NM_011968 PSA6_MOUSE Q0VGS3 Q3TT07 Q3U6Y2 Q9QUM9 uc007noq.1 uc007noq.2 uc007noq.3 uc007noq.4 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:16857966, PubMed:22341445). Interacts with ALKBH4 (By similarity). Cytoplasm Nucleus Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (By similarity). Colocalizes with TRIM5 in cytoplasmic bodies (PubMed:22078707). Detected in liver (at protein level). Up-regulated in liver tumor tissues (at protein level). Belongs to the peptidase T1A family. proteasome complex P-body RNA binding endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex polysome proteolysis ubiquitin-dependent protein catabolic process skeletal muscle tissue development peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process nuclear matrix hydrolase activity proteasome core complex, alpha-subunit complex myofibril sarcomere proteasome-mediated ubiquitin-dependent protein catabolic process NF-kappaB binding positive regulation of NF-kappaB transcription factor activity proteolysis involved in cellular protein catabolic process uc007noq.1 uc007noq.2 uc007noq.3 uc007noq.4 
ENSMUST00000021413.9 Nfkbia ENSMUST00000021413.9 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha (from RefSeq NM_010907.2) ENSMUST00000021413.1 ENSMUST00000021413.2 ENSMUST00000021413.3 ENSMUST00000021413.4 ENSMUST00000021413.5 ENSMUST00000021413.6 ENSMUST00000021413.7 ENSMUST00000021413.8 IKBA_MOUSE Ikba NM_010907 Q3U9W9 Q3UB40 Q80ZX5 Q9Z1E3 uc007nor.1 uc007nor.2 uc007nor.3 uc007nor.4 Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:10097128, PubMed:9990853). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7878466, PubMed:10097128, PubMed:9990853). Interacts with RELA; the interaction requires the nuclear import signal (By similarity). Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, ELP1 and MAP3K14 (By similarity). Interacts with NKIRAS1 and NKIRAS2 (By similarity). Interacts with RWDD3; the interaction enhances sumoylation (By similarity). Interacts with PRMT2 (By similarity). Interacts with PRKACA in platelets; this interaction is disrupted by thrombin and collagen (By similarity). Interacts with MEFV (By similarity). Interacts with DDRGK1; positively regulates NFKBIA phosphorylation and degradation (By similarity). Q9Z1E3; O88895: Hdac3; NbExp=2; IntAct=EBI-644427, EBI-302263; Q9Z1E3; Q04207: Rela; NbExp=9; IntAct=EBI-644427, EBI-644400; Q9Z1E3; Q04863: Relb; NbExp=4; IntAct=EBI-644427, EBI-1209145; Cytoplasm Nucleus Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1- dependent nuclear export. Highly expressed in lymph node, thymus followed by liver, brain, muscle, kidney, gastrointestinal and reproductive tract. Phosphorylated at Ser-32 and Ser-36 by IKKA/CHUK and IKKB/IKBKB; disables inhibition of NF-kappa-B DNA-binding activity (PubMed:7878466, PubMed:9859996, PubMed:9990853, PubMed:10097128). Phosphorylation at positions 32 and 36 is prerequisite to recognition by the SCF(FBXW11) and SCF(BTRC) complexes, leading to polyubiquitination and subsequent degradation (PubMed:9859996, PubMed:10097128). Polyubiquitinated at Lys-21 and/or Lys-22 following phosphorylation at Ser-32 and Ser-36 (PubMed:9990853). Monoubiquitinated at Lys-21 and/or Lys-22 by UBE2D3 (By similarity). Ubiquitin chain elongation is then performed by CDC34 in cooperation with the SCF(FBXW11) E3 ligase complex, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin (By similarity). The resulting polyubiquitination leads to protein degradation (By similarity). Also ubiquitinated by the SCF(BTRC) complex following stimulus-dependent phosphorylation at Ser-32 and Ser-36 (By similarity). Deubiquitinated by USP38, leading to NF-kappa-B inhibition (By similarity). Sumoylated; sumoylation requires the presence of the nuclear import signal. Sumoylation blocks ubiquitination and proteasome- mediated degradation of the protein thereby increasing the protein stability. Hydroxylated by HIF1AN. Belongs to the NF-kappa-B inhibitor family. protein binding nucleus cytoplasm cytosol plasma membrane protein import into nucleus I-kappaB kinase/NF-kappaB signaling cytoplasmic sequestering of NF-kappaB nuclear localization sequence binding regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of cholesterol efflux negative regulation of lipid storage enzyme binding heat shock protein binding ubiquitin protein ligase binding lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity positive regulation of cellular protein metabolic process response to muramyl dipeptide response to lipopolysaccharide macromolecular complex tumor necrosis factor-mediated signaling pathway toll-like receptor 4 signaling pathway response to muscle stretch regulation of cell proliferation identical protein binding cytoplasmic sequestering of transcription factor response to exogenous dsRNA macromolecular complex binding negative regulation of myeloid cell differentiation negative regulation of Notch signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of inflammatory response NF-kappaB binding nucleotide-binding oligomerization domain containing 1 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to cytokine stimulus cellular response to tumor necrosis factor cellular response to organic cyclic compound uc007nor.1 uc007nor.2 uc007nor.3 uc007nor.4 
ENSMUST00000021416.9 Mbip ENSMUST00000021416.9 MAP3K12 binding inhibitory protein 1 (from RefSeq NM_145442.2) ENSMUST00000021416.1 ENSMUST00000021416.2 ENSMUST00000021416.3 ENSMUST00000021416.4 ENSMUST00000021416.5 ENSMUST00000021416.6 ENSMUST00000021416.7 ENSMUST00000021416.8 MBIP1_MOUSE NM_145442 Q3TBM3 Q99LQ1 uc007npc.1 uc007npc.2 uc007npc.3 uc007npc.4 uc007npc.5 Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, KAT14 and WDR5. Nucleus Cytoplasm Note=Shows a cytoplasmic localization when co-expressed with MAP3K12. protein binding nucleus Ada2/Gcn5/Ada3 transcription activator complex nucleolus cytoplasm cytosol molybdopterin synthase activity identical protein binding histone H3 acetylation uc007npc.1 uc007npc.2 uc007npc.3 uc007npc.4 uc007npc.5 
ENSMUST00000021420.14 Ngb ENSMUST00000021420.14 neuroglobin, transcript variant 2 (from RefSeq NM_022414.2) ENSMUST00000021420.1 ENSMUST00000021420.10 ENSMUST00000021420.11 ENSMUST00000021420.12 ENSMUST00000021420.13 ENSMUST00000021420.2 ENSMUST00000021420.3 ENSMUST00000021420.4 ENSMUST00000021420.5 ENSMUST00000021420.6 ENSMUST00000021420.7 ENSMUST00000021420.8 ENSMUST00000021420.9 NGB_MOUSE NM_022414 Q9ER97 uc007oii.1 uc007oii.2 Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti- apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. Monomer. Homodimer and homotetramer; disulfide-linked (Probable). Interacts with 14-3-3 (By similarity). Perikaryon Cytoplasm Mitochondrion Predominantly expressed in brain. A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO. Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity (By similarity). Belongs to the globin family. oxygen transporter activity protein binding cytoplasm mitochondrion apoptotic process visual perception oxygen transport oxygen binding heme binding neuron projection development neuron projection positive regulation of catalytic activity perikaryon metal ion binding negative regulation of hydrogen peroxide-induced cell death uc007oii.1 uc007oii.2 
ENSMUST00000021424.5 Sptlc2 ENSMUST00000021424.5 serine palmitoyltransferase, long chain base subunit 2 (from RefSeq NM_011479.4) ENSMUST00000021424.1 ENSMUST00000021424.2 ENSMUST00000021424.3 ENSMUST00000021424.4 NM_011479 Q542D6 Q542D6_MOUSE Sptlc2 uc007oiw.1 uc007oiw.2 uc007oiw.3 This gene encodes a long chain base subunit of serine palmitoyltransferase. The enzyme, serine palmitoyltransferase, consists of two different subunits, and is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. A mutant allele of this gene in mice is used as a model for the human disease 'Susceptibilty to Psoriasis 1'. Mutations in the human gene are associated with hereditary sensory neuropathy type I. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK044917.1, SRR1660819.51550.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence= Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. catalytic activity serine C-palmitoyltransferase activity biosynthetic process transferase activity serine C-palmitoyltransferase complex sphingolipid biosynthetic process pyridoxal phosphate binding ceramide biosynthetic process positive regulation of lipophagy uc007oiw.1 uc007oiw.2 uc007oiw.3 
ENSMUST00000021425.8 Ahsa1 ENSMUST00000021425.8 AHA1, activator of heat shock protein ATPase 1, transcript variant 1 (from RefSeq NM_146036.2) AHSA1_MOUSE ENSMUST00000021425.1 ENSMUST00000021425.2 ENSMUST00000021425.3 ENSMUST00000021425.4 ENSMUST00000021425.5 ENSMUST00000021425.6 ENSMUST00000021425.7 NM_146036 Q8BK64 Q8R3E6 uc007oit.1 uc007oit.2 uc007oit.3 Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co- chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Interacts with HSPCA/HSP90 (By similarity). Interacts with HSP90AA1; the interaction activates HSP90AA1 ATPase activity (PubMed:29127155). Interacts with HSP90AB1 (PubMed:22022502). Interacts with GCH1 (By similarity). Interacts with SRPK1 (By similarity). Interacts with FLCN (By similarity). Cytoplasm, cytosol Endoplasmic reticulum Note=May transiently interact with the endoplasmic reticulum. By heat shock and treatment with the HSP90 inhibitor 17- demethoxygeldanamycin (17AAG). Phosphorylation at Tyr-223 enhances binding to chaperone HSP90AA1. Belongs to the AHA1 family. ATPase activator activity protein binding cytoplasm endoplasmic reticulum cytosol protein folding positive regulation of ATPase activity chaperone binding Hsp90 protein binding uc007oit.1 uc007oit.2 uc007oit.3 
ENSMUST00000021428.9 Snw1 ENSMUST00000021428.9 SNW domain containing 1 (from RefSeq NM_025507.2) A0A0B4J1E2 A0A0B4J1E2_MOUSE ENSMUST00000021428.1 ENSMUST00000021428.2 ENSMUST00000021428.3 ENSMUST00000021428.4 ENSMUST00000021428.5 ENSMUST00000021428.6 ENSMUST00000021428.7 ENSMUST00000021428.8 NM_025507 Snw1 uc007ojf.1 uc007ojf.2 uc007ojf.3 Involved in pre-mRNA splicing. Identified in the spliceosome C complex. Nucleus Belongs to the SNW family. mRNA splicing, via spliceosome chromatin nucleoplasm spliceosomal complex cytoplasm Schwann cell proliferation SMAD protein complex uc007ojf.1 uc007ojf.2 uc007ojf.3 
ENSMUST00000021438.8 Nova1 ENSMUST00000021438.8 NOVA alternative splicing regulator 1, transcript variant 1 (from RefSeq NM_021361.2) ENSMUST00000021438.1 ENSMUST00000021438.2 ENSMUST00000021438.3 ENSMUST00000021438.4 ENSMUST00000021438.5 ENSMUST00000021438.6 ENSMUST00000021438.7 NM_021361 NOVA1_MOUSE Nova1 Q8C8B9 Q9JKN6 uc007nmd.1 uc007nmd.2 uc007nmd.3 uc007nmd.4 Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion (PubMed:8558240, PubMed:15933722, PubMed:17065982, PubMed:14615540). It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons (PubMed:9154818, PubMed:8558240, PubMed:14615540). Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion (PubMed:10719891). Binding to 5'-YCAY-3' clusters results in a local and asymmetric action to regulate spliceosome assembly and alternative splicing in neurons. Binding to an exonic 5'-YCAY-3' cluster changed the protein complexes assembled on pre-mRNA, blocking U1 snRNP (small nuclear ribonucleoprotein) binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhanced spliceosome assembly and exon inclusion (PubMed:17065982, PubMed:15933722). With NOVA1, they perform unique biological functions in different brain areas and cell types (PubMed:30638744). Autoregulates its own expression by acting as a splicing repressor (PubMed:15933722). Acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric- acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer (PubMed:12808107). Acts to regulate a novel glycine receptor alpha-2 chain splice variant (alpha-2N) in developing spinal cord (PubMed:17065982). Interacts with PTBP2; the interaction is direct. Nucleus Expressed in neurons of the cortex, sub-cortex, cerebellum and brainstem (at protein level)(PubMed:10829067). Expressed in motor neurons, but not in glia (PubMed:10829067). The KH domain consists of approximately 70 amino acids and includes a conserved hydrophobic core, an invariant Gly-X-X-Gly motif, and an additional variable segment. The third KH domain (KH3) binds a hairpin RNA loop containing the 5'-UCAY-3' motif on targeted molecules. RNA binding by KH3 requires residues C-terminal to the KH domain. Note=Defects in Nova1 leads to neuronal death in spinal and brainstem neurons. mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding nucleus nucleolus intracellular membrane-bounded organelle regulation of mRNA processing regulation of RNA metabolic process uc007nmd.1 uc007nmd.2 uc007nmd.3 uc007nmd.4 
ENSMUST00000021443.7 Mthfd1 ENSMUST00000021443.7 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase (from RefSeq NM_138745.2) C1TC_MOUSE ENSMUST00000021443.1 ENSMUST00000021443.2 ENSMUST00000021443.3 ENSMUST00000021443.4 ENSMUST00000021443.5 ENSMUST00000021443.6 NM_138745 Q8R013 Q922D8 uc007nxz.1 uc007nxz.2 uc007nxz.3 uc007nxz.4 This gene encodes a trifunctional cytoplasmic enzyme. The encoded protein functions as a methylenetetrahydrofolate dehydrogenase, a methenyltetrahydrofolate cyclohydrolase, and a formyltetrahydrofolate synthase. The encoded enzyme functions in de novo synthesis of purines and thymidylate and in regeneration of methionine from homocysteine. [provided by RefSeq, Oct 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK129012.1, SRR1660815.187204.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10- methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate. These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance. Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)- 5,10-methenyltetrahydrofolate + NADPH; Xref=Rhea:RHEA:22812, ChEBI:CHEBI:15636, ChEBI:CHEBI:57455, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.5; Evidence=; Reaction=(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10- formyltetrahydrofolate + H(+); Xref=Rhea:RHEA:23700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57455, ChEBI:CHEBI:195366; EC=3.5.4.9; Evidence=; Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10- formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221, ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57453, ChEBI:CHEBI:195366, ChEBI:CHEBI:456216; EC=6.3.4.3; Evidence=; One-carbon metabolism; tetrahydrofolate interconversion. Homodimer. Cytoplasm The N-terminal methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase (D/C) domain carries both the methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The larger C-terminal formyltetrahydrofolate synthetase domain carries a third formyltetrahydrofolate synthetase activity. In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. histidine biosynthetic process nucleotide binding neutrophil homeostasis neural tube closure catalytic activity formate-tetrahydrofolate ligase activity methenyltetrahydrofolate cyclohydrolase activity methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity methylenetetrahydrofolate dehydrogenase (NAD+) activity methylenetetrahydrofolate dehydrogenase (NADP+) activity ATP binding cytoplasm mitochondrion cytosol purine nucleotide biosynthetic process methionine metabolic process one-carbon metabolic process heart development metabolic process cellular amino acid biosynthetic process serine family amino acid metabolic process serine family amino acid biosynthetic process methionine biosynthetic process purine nucleobase biosynthetic process 10-formyltetrahydrofolate biosynthetic process oxidoreductase activity hydrolase activity ligase activity transsulfuration tetrahydrofolate interconversion oxidation-reduction process somite development uc007nxz.1 uc007nxz.2 uc007nxz.3 uc007nxz.4 
ENSMUST00000021447.9 Ppp2r5e ENSMUST00000021447.9 protein phosphatase 2, regulatory subunit B', epsilon (from RefSeq NM_012024.3) 2A5E_MOUSE ENSMUST00000021447.1 ENSMUST00000021447.2 ENSMUST00000021447.3 ENSMUST00000021447.4 ENSMUST00000021447.5 ENSMUST00000021447.6 ENSMUST00000021447.7 ENSMUST00000021447.8 Kiaa4006 NM_012024 Q3V1I5 Q571M6 Q61151 Q8C2M2 uc007nxe.1 uc007nxe.2 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Interacts with cyclin G in vitro. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1. Found in a complex with at least ARL2, PPP2CB; PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Cytoplasm Belongs to the phosphatase 2A regulatory subunit B56 family. Sequence=AAB37234.1; Type=Frameshift; Evidence=; Sequence=BAD90335.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein phosphatase type 2A complex nucleus cytoplasm cytosol protein dephosphorylation signal transduction protein phosphatase regulator activity regulation of protein autophosphorylation regulation of phosphoprotein phosphatase activity protein phosphatase activator activity uc007nxe.1 uc007nxe.2 
ENSMUST00000021450.6 Sgpp1 ENSMUST00000021450.6 sphingosine-1-phosphate phosphatase 1 (from RefSeq NM_030750.3) ENSMUST00000021450.1 ENSMUST00000021450.2 ENSMUST00000021450.3 ENSMUST00000021450.4 ENSMUST00000021450.5 NM_030750 Q9JI99 SGPP1_MOUSE Sgpp1 Spp1 Spph1 uc007nxk.1 uc007nxk.2 uc007nxk.3 uc007nxk.4 Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P (PubMed:10859351, PubMed:11756451). Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid. Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway. Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:10859351, Ref.2). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase (PubMed:12235122, PubMed:17895250). In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (PubMed:17895250). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (By similarity). The modulation of intracellular ceramide levels in turn regulates apoptosis (PubMed:12235122). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries. Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (By similarity). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (PubMed:23637227). Reaction=H2O + sphinganine 1-phosphate = phosphate + sphinganine; Xref=Rhea:RHEA:27514, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57817, ChEBI:CHEBI:57939; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27515; Evidence=; Reaction=H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine; Xref=Rhea:RHEA:27518, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27519; Evidence=; Inhibited by NaF, sodium orthovanadate, propanolol, and N-ethylmaleimide. Kinetic parameters: KM=38.5 uM for sphingosine 1-phosphate ; Vmax=36.4 nmol/min/mg enzyme for sphingosine 1-phosphate ; pH dependence: Optimum pH is 6-7.5. ; Endoplasmic reticulum membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Mainly found in intracellular membrane fractions. Highly expressed in liver and kidney. Expressed in epidermis, in the stratum granulosum and the stratum spinosum (PubMed:23637227). Mutants appear normal at birth, but during the first week of life they exhibit stunted growth and suffer desquamation, with most dying before weaning (PubMed:23637227). Their subcorneal layers, including the stratum granulosum, stratum spinosum, and stratum basale, are significantly thicker, whereas the stratum corneum is thinner than in wild-type mic (PubMed:23637227). Belongs to the type 2 lipid phosphate phosphatase family. nucleus nucleoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane sphingolipid metabolic process sphinganine-1-phosphate metabolic process sphingosine metabolic process membrane integral component of membrane dephosphorylation hydrolase activity ER to Golgi ceramide transport sphingosine-1-phosphate phosphatase activity regulation of keratinocyte differentiation regulation of epidermis development extrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway mitochondrion Golgi apparatus actin cytoskeleton uc007nxk.1 uc007nxk.2 uc007nxk.3 uc007nxk.4 
ENSMUST00000021458.13 Sptb ENSMUST00000021458.13 spectrin beta, erythrocytic (from RefSeq NM_013675.3) ENSMUST00000021458.1 ENSMUST00000021458.10 ENSMUST00000021458.11 ENSMUST00000021458.12 ENSMUST00000021458.2 ENSMUST00000021458.3 ENSMUST00000021458.4 ENSMUST00000021458.5 ENSMUST00000021458.6 ENSMUST00000021458.7 ENSMUST00000021458.8 ENSMUST00000021458.9 NM_013675 Q3UGX2 Q3UGX2_MOUSE Spnb1 Sptb uc007nyo.1 uc007nyo.2 Belongs to the spectrin family. actin binding structural constituent of cytoskeleton phospholipid binding cytoplasm Golgi apparatus cytosol cytoskeleton cytoskeleton organization spectrin spectrin-associated cytoskeleton ankyrin binding macromolecular complex actin filament binding actin filament capping uc007nyo.1 uc007nyo.2 
ENSMUST00000021459.14 Rab15 ENSMUST00000021459.14 RAB15, member RAS oncogene family, transcript variant 1 (from RefSeq NM_134050.5) ENSMUST00000021459.1 ENSMUST00000021459.10 ENSMUST00000021459.11 ENSMUST00000021459.12 ENSMUST00000021459.13 ENSMUST00000021459.2 ENSMUST00000021459.3 ENSMUST00000021459.4 ENSMUST00000021459.5 ENSMUST00000021459.6 ENSMUST00000021459.7 ENSMUST00000021459.8 ENSMUST00000021459.9 NM_134050 Q3TYH2 Q3TYH2_MOUSE Rab15 uc007nyt.1 uc007nyt.2 uc007nyt.3 uc007nyt.4 uc007nyt.5 Membrane ; Lipid- anchor ; Cytoplasmic side Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding cytoplasm cilium endosome membrane Rab protein signal transduction perinuclear region of cytoplasm positive regulation of regulated secretory pathway uc007nyt.1 uc007nyt.2 uc007nyt.3 uc007nyt.4 uc007nyt.5 
ENSMUST00000021466.10 Atl1 ENSMUST00000021466.10 atlastin GTPase 1 (from RefSeq NM_178628.5) ATLA1_MOUSE ENSMUST00000021466.1 ENSMUST00000021466.2 ENSMUST00000021466.3 ENSMUST00000021466.4 ENSMUST00000021466.5 ENSMUST00000021466.6 ENSMUST00000021466.7 ENSMUST00000021466.8 ENSMUST00000021466.9 NM_178628 Q8BH66 Q8BJH5 Spg3a uc007nsy.1 uc007nsy.2 uc007nsy.3 uc007nsy.4 This gene encodes a member of the dynamin family of GTPases. The encoded protein interacts with tubule-shaping proteins of the endoplasmic reticulum. Mutations in the homologous human gene can cause hereditary spastic paraplegia. [provided by RefSeq, Feb 2010]. ##Evidence-Data-START## Transcript exon combination :: AK050339.1, SRR1660815.49663.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Monomer as apoprotein and in the GDP-bound form. Homodimer in the GTP-bound form. Homooligomer. Interacts (via N-terminal region) with MAP4K4 (via CNH regulatory domain). Interacts with SPAST; interaction is direct (By similarity). Interacts with REEP5, RTN3 and probably RTN4 (via the transmembrane region) (PubMed:19665976). Interacts with REEP1. Interacts with CPT1C. Interacts with ARL6IP1 (By similarity). Interacts with ZFYVE27 (PubMed:24668814). Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Cell projection, axon Note=Localizes to endoplasmic reticulum tubular network. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily. Golgi cis cisterna Golgi membrane nucleotide binding GTPase activity protein binding GTP binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus endoplasmic reticulum organization axonogenesis membrane integral component of membrane hydrolase activity axon identical protein binding cell projection protein homooligomerization endoplasmic reticulum tubular network endoplasmic reticulum tubular network membrane endoplasmic reticulum tubular network membrane organization uc007nsy.1 uc007nsy.2 uc007nsy.3 uc007nsy.4 
ENSMUST00000021467.8 Sav1 ENSMUST00000021467.8 salvador family WW domain containing 1, transcript variant 1 (from RefSeq NM_022028.3) ENSMUST00000021467.1 ENSMUST00000021467.2 ENSMUST00000021467.3 ENSMUST00000021467.4 ENSMUST00000021467.5 ENSMUST00000021467.6 ENSMUST00000021467.7 NM_022028 Q8VEB2 Q9D9N9 Q9ER46 SAV1_MOUSE Ww45 Wwp3 uc007nte.1 uc007nte.2 uc007nte.3 uc007nte.4 Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (By similarity). Homodimer. Stabilized through interaction with STK3/MST2 or STK4/MST1. Interacts (via SARAH domain) with isoform 1 of NEK2. Interacts with ESR1 only in the presence of STK3/MST2. Interacts with WTIP and AJUBA. Nucleus Cytoplasm Ubiquitously expressed in adult tissues with the highest level found in testis. Expression was detected in 7 dpc embryos. Expression levels decreased at day 11 and remained low at days 15 and 17. Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule (By similarity). Mice show progressive hepatomegaly with a 2-fold increase in liver mass relative to total body mass at 1 month of age and a 3-fold increase by 3 months of age. Embryos display unchecked proliferation and defects in terminal differentiation of epithelial cells. hair follicle development protein binding nucleus cytoplasm cytosol apoptotic process signal transduction keratinocyte differentiation hippo signaling regulation of cell proliferation identical protein binding positive regulation of apoptotic process positive regulation of fat cell differentiation regulation of organ growth negative regulation of epithelial cell proliferation protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of cardiac muscle cell proliferation binding, bridging ventricular septum morphogenesis lung epithelial cell differentiation intestinal epithelial cell differentiation regulation of stem cell population maintenance uc007nte.1 uc007nte.2 uc007nte.3 uc007nte.4 
ENSMUST00000021471.13 Tmx1 ENSMUST00000021471.13 thioredoxin-related transmembrane protein 1 (from RefSeq NM_028339.1) ENSMUST00000021471.1 ENSMUST00000021471.10 ENSMUST00000021471.11 ENSMUST00000021471.12 ENSMUST00000021471.2 ENSMUST00000021471.3 ENSMUST00000021471.4 ENSMUST00000021471.5 ENSMUST00000021471.6 ENSMUST00000021471.7 ENSMUST00000021471.8 ENSMUST00000021471.9 NM_028339 Q3UCI8 Q8VBT0 Q9CSD5 TMX1_MOUSE Tmx1 Txndc Txndc1 uc007ntu.1 uc007ntu.2 uc007ntu.3 Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:26246604). Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol (By similarity). The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (By similarity). Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds (PubMed:26246604). Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane (PubMed:26246604). Involved in ER-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane (By similarity). Acts as a negative regulator of platelet aggregation following secretion in the extracellular space (PubMed:30425049). Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals (By similarity). Regulates endoplasmic reticulum-mitochondria Ca(2+) flux (By similarity). Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; Evidence=; Interacts with ATP2A2. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Mitochondrion membrane ; Single-pass type I membrane protein Secreted Note=Predominantly found in the endoplasmic reticulum. Secreted in the extracellular space following thrombin stimulation. Localizes to mitochondria-associated endoplasmic reticulum membrane (MAM); palmitoylation is required for MAM localization. Palmitoylated; palmitoylation is required for localization to mitochondria-associated endoplasmic reticulum membrane (MAM). Deficiency potentiates platelet function: mice display increased incorporation of platelets into a growing thrombus in an injury model, as well as shortened tail-bleeding times. endoplasmic reticulum endoplasmic reticulum membrane disulfide oxidoreductase activity membrane integral component of membrane response to endoplasmic reticulum stress cell redox homeostasis oxidation-reduction process uc007ntu.1 uc007ntu.2 uc007ntu.3 
ENSMUST00000021479.6 Actr10 ENSMUST00000021479.6 ARP10 actin-related protein 10 (from RefSeq NM_019785.2) ARP10_MOUSE Act11 Actr11 Arp10 Arp11 ENSMUST00000021479.1 ENSMUST00000021479.2 ENSMUST00000021479.3 ENSMUST00000021479.4 ENSMUST00000021479.5 NM_019785 Q3TT18 Q99LU1 Q9QZB7 uc007nty.1 uc007nty.2 uc007nty.3 uc007nty.4 Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Q9QZB7; P42025: ACTR1B; Xeno; NbExp=2; IntAct=EBI-367600, EBI-367493; Cytoplasm, cytoskeleton Belongs to the actin family. establishment of mitotic spindle orientation protein binding cytoplasm centrosome cytoskeleton dynactin complex microtubule-based movement nuclear migration along microtubule retrograde axonal transport of mitochondrion cell cortex region axon cytoplasm uc007nty.1 uc007nty.2 uc007nty.3 uc007nty.4 
ENSMUST00000021482.6 Tomm20l ENSMUST00000021482.6 translocase of outer mitochondrial membrane 20-like (from RefSeq NM_029227.1) ENSMUST00000021482.1 ENSMUST00000021482.2 ENSMUST00000021482.3 ENSMUST00000021482.4 ENSMUST00000021482.5 NM_029227 Q9D4V6 TO20L_MOUSE uc007nug.1 uc007nug.2 uc007nug.3 Mitochondrion outer membrane ; Single-pass membrane protein Belongs to the Tom20 family. mitochondrion mitochondrial outer membrane mitochondrial outer membrane translocase complex protein targeting intracellular protein transport P-P-bond-hydrolysis-driven protein transmembrane transporter activity membrane integral component of membrane tRNA import into mitochondrion protein import into mitochondrial matrix mitochondrion targeting sequence binding integral component of mitochondrial outer membrane mitochondrial outer membrane translocase complex assembly protein transmembrane transporter activity uc007nug.1 uc007nug.2 uc007nug.3 
ENSMUST00000021486.10 Timm9 ENSMUST00000021486.10 translocase of inner mitochondrial membrane 9, transcript variant 3 (from RefSeq NM_001024854.1) ENSMUST00000021486.1 ENSMUST00000021486.2 ENSMUST00000021486.3 ENSMUST00000021486.4 ENSMUST00000021486.5 ENSMUST00000021486.6 ENSMUST00000021486.7 ENSMUST00000021486.8 ENSMUST00000021486.9 NM_001024854 Q9WV98 TIM9_MOUSE Tim9 Tim9a Timm9a uc007nuj.1 uc007nuj.2 uc007nuj.3 Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6- bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). Belongs to the small Tim family. mitochondrion mitochondrial inner membrane protein transport membrane mitochondrial intermembrane space protein transporter complex protein homodimerization activity protein import into mitochondrial inner membrane metal ion binding chaperone binding chaperone-mediated protein transport uc007nuj.1 uc007nuj.2 uc007nuj.3 
ENSMUST00000021490.12 Serpina1f ENSMUST00000021490.12 serine (or cysteine) peptidase inhibitor, clade A, member 1F, transcript variant 1 (from RefSeq NM_026687.2) ENSMUST00000021490.1 ENSMUST00000021490.10 ENSMUST00000021490.11 ENSMUST00000021490.2 ENSMUST00000021490.3 ENSMUST00000021490.4 ENSMUST00000021490.5 ENSMUST00000021490.6 ENSMUST00000021490.7 ENSMUST00000021490.8 ENSMUST00000021490.9 G3X9Z5 G3X9Z5_MOUSE NM_026687 Serpina1f uc007owd.1 uc007owd.2 uc007owd.3 uc007owd.4 Belongs to the serpin family. extracellular space uc007owd.1 uc007owd.2 uc007owd.3 uc007owd.4 
ENSMUST00000021494.6 Ccdc175 ENSMUST00000021494.6 coiled-coil domain containing 175 (from RefSeq NM_028687.1) CC175_MOUSE E9PVB3 ENSMUST00000021494.1 ENSMUST00000021494.2 ENSMUST00000021494.3 ENSMUST00000021494.4 ENSMUST00000021494.5 NM_028687 uc007nvh.1 uc007nvh.2 uc007nvh.3 uc007nvh.4 molecular_function cellular_component biological_process uc007nvh.1 uc007nvh.2 uc007nvh.3 uc007nvh.4 
ENSMUST00000021495.4 Serpina5 ENSMUST00000021495.4 serine (or cysteine) peptidase inhibitor, clade A, member 5 (from RefSeq NM_172953.3) ENSMUST00000021495.1 ENSMUST00000021495.2 ENSMUST00000021495.3 IPSP_MOUSE NM_172953 P70458 Pci Q5BKQ8 Q8BU50 uc007ows.1 uc007ows.2 Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and pro-inflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue- and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C- catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary- type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid (By similarity). Its inhibitory activity is greatly enhanced in the presence of glycosaminoglycans, heparin, thrombomodulin and phospholipids vesicles. Forms protease inhibiting heterodimers in extracellular body fluids with serine proteases such as activated protein C/coagulation factor V/F5, acrosin/ACR, chymotrypsinogen B/CTRB1, prothrombin/F2, factor Xa/F10, factor XI/F11, kallikrein/KLKB1, tissue kallikrein, trypsin/PRSS1, prostate specific antigen/KLK3, tissue plasminogen activator/PLAT and urinary plasminogen activator/PLAU. Forms membrane- anchored serine proteases inhibiting heterodimers with TMPRSS7 and TMPRSS11E. Interacts with SEMG2 (By similarity). P70458; Q5S248: Tmprss11e; NbExp=2; IntAct=EBI-490966, EBI-490889; Secreted, extracellular space Note=Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spermatozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets (By similarity). Not detected in blood plasma (at protein level). Expressed in testis, epididymis, seminal vesicles, prostate and ovaries. The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin- protease complex is highly stable (By similarity). N-glycosylated; glycans consist of a mixture of sialylated bi- (including sialyl-Lewis X epitopes), tri- and tetra-antennary complex-type chains; affects the maximal heparin- and thrombomodulin- enhanced rates of thrombin inhibition. O-glycosylated; further modified with 2 sialic acid residues. Proteolytically cleaved at the N-terminus; inhibits slightly the heparin- and thrombomodulin-enhanced rates of thrombin inhibition (By similarity). Proteolytically cleaved. Inhibition of proteases is accompanied by formation of a stable enzyme-inhibitor complex and by degradation of the serpin to lower molecular weight derivatives (By similarity). Mice are healthy but males are infertile; spermatozoa are morphologically abnormal, most lacked tails and malformed heads. The lumina of the seminiferous tubules are filled with cells in different stages of spermatogenesis and are sometimes necrotic. The cytoplasm of Sertoli cells contained vacuoles and appeared necrotic. The Sertoli cell barrier appeared disrupted. Belongs to the serpin family. According to PubMed:11120760 it is not detectable in blood plasma. retinoic acid binding protease binding acrosomal membrane serine-type endopeptidase inhibitor activity protein binding extracellular region extracellular space spermatogenesis external side of plasma membrane negative regulation of peptidase activity negative regulation of endopeptidase activity membrane peptidase inhibitor activity platelet alpha granule platelet dense tubular network phosphatidylcholine binding acrosin binding macromolecular complex protein C inhibitor-TMPRSS7 complex protein C inhibitor-TMPRSS11E complex protein C inhibitor-PLAT complex protein C inhibitor-PLAU complex protein C inhibitor-thrombin complex protein C inhibitor-KLK3 complex protein C inhibitor-plasma kallikrein complex negative regulation of proteolysis negative regulation of hydrolase activity extracellular exosome protein C inhibitor-coagulation factor V complex protein C inhibitor-coagulation factor Xa complex protein C inhibitor-coagulation factor XI complex uc007ows.1 uc007ows.2 
ENSMUST00000021497.16 Rtn1 ENSMUST00000021497.16 reticulon 1, transcript variant 2 (from RefSeq NM_001007596.2) ENSMUST00000021497.1 ENSMUST00000021497.10 ENSMUST00000021497.11 ENSMUST00000021497.12 ENSMUST00000021497.13 ENSMUST00000021497.14 ENSMUST00000021497.15 ENSMUST00000021497.2 ENSMUST00000021497.3 ENSMUST00000021497.4 ENSMUST00000021497.5 ENSMUST00000021497.6 ENSMUST00000021497.7 ENSMUST00000021497.8 ENSMUST00000021497.9 NM_001007596 Q7M6W1 Q7M6W1_MOUSE Rtn1 uc007nvj.1 uc007nvj.2 uc007nvj.3 uc007nvj.4 Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. Endoplasmic reticulum membrane ; Multi- pass membrane protein mbrane ; Multi-pass membrane protein endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane uc007nvj.1 uc007nvj.2 uc007nvj.3 uc007nvj.4 
ENSMUST00000021506.6 Serpina3n ENSMUST00000021506.6 serine (or cysteine) peptidase inhibitor, clade A, member 3N (from RefSeq NM_009252.2) ENSMUST00000021506.1 ENSMUST00000021506.2 ENSMUST00000021506.3 ENSMUST00000021506.4 ENSMUST00000021506.5 G3X8T9 G3X8T9_MOUSE NM_009252 Serpina3n uc007oxg.1 uc007oxg.2 uc007oxg.3 Belongs to the serpin family. extracellular space uc007oxg.1 uc007oxg.2 uc007oxg.3 
ENSMUST00000021512.11 Dhrs7 ENSMUST00000021512.11 dehydrogenase/reductase 7 (from RefSeq NM_025522.5) DHRS7_MOUSE Dhrs7 ENSMUST00000021512.1 ENSMUST00000021512.10 ENSMUST00000021512.2 ENSMUST00000021512.3 ENSMUST00000021512.4 ENSMUST00000021512.5 ENSMUST00000021512.6 ENSMUST00000021512.7 ENSMUST00000021512.8 ENSMUST00000021512.9 NM_025522 Q9CXR1 Retsdr4 uc007nvs.1 uc007nvs.2 uc007nvs.3 uc007nvs.4 NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics. Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function. Involved in the reduction of all-trans-retinal to all-trans-retinol. Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable. Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group. A dehydrogenase activity has not been detected so far. May play a role as tumor suppressor. Reaction=all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH; Xref=Rhea:RHEA:25033, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:25035; Evidence=; Reaction=5alpha-androstane-3alpha,17beta-diol + NADP(+) = 17beta- hydroxy-5alpha-androstan-3-one + H(+) + NADPH; Xref=Rhea:RHEA:42116, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:36713, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42118; Evidence=; Endoplasmic reticulum membrane Note=Bound to the endoplasmic reticulum membrane, possibly through a N-terminus anchor. The main bulk of the polypeptide chain was first reported to be facing toward the lumen of the endoplasmic reticulum. However, it was later shown to be facing the cytosol. Belongs to the short-chain dehydrogenases/reductases (SDR) family. DHRS7 was originally reported to be anchored in the endoplasmic reticulum membrane and facing the lumen (By similarity). However, the catalytic moiety was later shown to be facing the cytosol (By similarity). Sequence=AAH16189.1; Type=Erroneous initiation; Evidence=; Sequence=BAB29156.1; Type=Frameshift; Evidence=; biological_process oxidoreductase activity oxidation-reduction process uc007nvs.1 uc007nvs.2 uc007nvs.3 uc007nvs.4 
ENSMUST00000021513.6 Gsc ENSMUST00000021513.6 goosecoid homeobox (from RefSeq NM_010351.1) ENSMUST00000021513.1 ENSMUST00000021513.2 ENSMUST00000021513.3 ENSMUST00000021513.4 ENSMUST00000021513.5 GSC_MOUSE NM_010351 Q02591 uc007oxh.1 uc007oxh.2 uc007oxh.3 Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis (By similarity). In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Goosecoid-expressing regions of the gastrulating mouse egg cylinder have organizer-like activity when transplanted into Xenopus embryos. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity). Q02591; O88621: Foxh1; NbExp=2; IntAct=EBI-7457485, EBI-7457430; Q02591; O09106: Hdac1; NbExp=2; IntAct=EBI-7457485, EBI-301912; Nucleus. In early gastrulation, expressed in the dorsal lip. In later stages of development found in head, limbs and body wall. In the embryo, expressed in the postotic cranial neural crest cells, the frontonasal prominence, the first branchial arch and cleft, and specific regions of large joints. By activin. Belongs to the paired homeobox family. Bicoid subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor binding RNA polymerase II repressing transcription factor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated multicellular organism development anatomical structure morphogenesis neural crest cell fate specification nuclear body dorsal/ventral neural tube patterning signal transduction involved in regulation of gene expression negative regulation of Wnt signaling pathway forebrain development middle ear morphogenesis sequence-specific DNA binding ear development muscle organ morphogenesis embryonic skeletal system morphogenesis uc007oxh.1 uc007oxh.2 uc007oxh.3 
ENSMUST00000021514.10 Ppm1a ENSMUST00000021514.10 protein phosphatase 1A, magnesium dependent, alpha isoform (from RefSeq NM_008910.3) ENSMUST00000021514.1 ENSMUST00000021514.2 ENSMUST00000021514.3 ENSMUST00000021514.4 ENSMUST00000021514.5 ENSMUST00000021514.6 ENSMUST00000021514.7 ENSMUST00000021514.8 ENSMUST00000021514.9 NM_008910 P49443 PPM1A_MOUSE Pppm1a uc007nvu.1 uc007nvu.2 uc007nvu.3 uc007nvu.4 Enzyme with a broad specificity. Negatively regulates TGF- beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit.; Monomer (By similarity). Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling (By similarity). Interacts with the phosphorylated form of IKBKB/IKKB (By similarity). Nucleus Cytoplasm, cytosol mbrane ; Lipid-anchor Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. N-myristoylation is essential for the recognition of its substrates for dephosphorylation. Belongs to the PP2C family. magnesium ion binding catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity nucleus cytoplasm cytosol plasma membrane protein dephosphorylation N-terminal protein myristoylation protein C-terminus binding negative regulation of SMAD protein complex assembly membrane dephosphorylation hydrolase activity manganese ion binding negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway calmodulin-dependent protein phosphatase activity peptidyl-threonine dephosphorylation neuron projection negative regulation of I-kappaB kinase/NF-kappaB signaling cation binding ion channel binding positive regulation of transcription, DNA-templated positive regulation of protein export from nucleus metal ion binding R-SMAD binding cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway negative regulation of NIK/NF-kappaB signaling uc007nvu.1 uc007nvu.2 uc007nvu.3 uc007nvu.4 
ENSMUST00000021519.7 Six6 ENSMUST00000021519.7 sine oculis-related homeobox 6 (from RefSeq NM_011384.5) ENSMUST00000021519.1 ENSMUST00000021519.2 ENSMUST00000021519.3 ENSMUST00000021519.4 ENSMUST00000021519.5 ENSMUST00000021519.6 NM_011384 O88423 Optx2 Q9QZ28 SIX6_MOUSE Six9 uc007nvy.1 uc007nvy.2 uc007nvy.3 uc007nvy.4 This gene encodes a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 12 and is thought to be involved in eye development. The encoded transcription factor regulates early progenitor cell proliferation during mammalian retinogenesis and pituitary development. Mice lacking this gene exhibit abnormal development of the suprachiasmatic nucleus and circadian rhythms. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK029309.1, BC138838.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## May be involved in eye development. Interacts with TLE4 and TLE5. Nucleus In the developing embryo, expressed mainly in the ventral optic stalk, optic chiasma, the neural retina and the primordial tissues that give rise to the pituitary/hypothalamus axis. Not expressed in the lens placode. Expression is first detected in the embryo at 8 dpc. Belongs to the SIX/Sine oculis homeobox family. transcription regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding eye development DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development negative regulation of transcription, DNA-templated anatomical structure development uc007nvy.1 uc007nvy.2 uc007nvy.3 uc007nvy.4 
ENSMUST00000021522.5 Glrx5 ENSMUST00000021522.5 glutaredoxin 5 (from RefSeq NM_028419.3) ENSMUST00000021522.1 ENSMUST00000021522.2 ENSMUST00000021522.3 ENSMUST00000021522.4 GLRX5_MOUSE NM_028419 Q3YML1 Q80Y14 Q9D6E9 uc007oxu.1 uc007oxu.2 uc007oxu.3 uc007oxu.4 This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in the human gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, Sep 2015]. ##Evidence-Data-START## Transcript exon combination :: AK013761.1, AK050883.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:19442627). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (By similarity). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (By similarity). Homodimer. Interacts with ISCU. Interacts with BOLA1. Mitochondrion matrix Detected in bone, liver, muscle and kidney. Ubiquitously expressed at 7.5 dpc. At 8.5 dpc, preferential expression in yolk sac blood islands. Progressive down- regulation in maturing primitive red cells between 10.5 and 12.5 dpc. High expression in fetal liver at 12.5 dpc. Belongs to the glutaredoxin family. Monothiol subfamily. Sequence=AAH50937.1; Type=Erroneous initiation; Evidence=; nucleus mitochondrion mitochondrial matrix electron carrier activity protein lipoylation protein disulfide oxidoreductase activity disulfide oxidoreductase activity electron transport chain hemopoiesis dendrite neuronal cell body cell redox homeostasis metal ion binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding oxidation-reduction process uc007oxu.1 uc007oxu.2 uc007oxu.3 uc007oxu.4 
ENSMUST00000021523.7 Mnat1 ENSMUST00000021523.7 menage a trois 1 (from RefSeq NM_008612.2) ENSMUST00000021523.1 ENSMUST00000021523.2 ENSMUST00000021523.3 ENSMUST00000021523.4 ENSMUST00000021523.5 ENSMUST00000021523.6 MAT1_MOUSE Mat1 NM_008612 P51949 Q14BS9 Q3TZP0 Q9D8A0 Q9D8D2 uc007nwe.1 uc007nwe.2 Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Associates primarily with CDK7 and cyclin H to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor. Nucleus regulation of cyclin-dependent protein serine/threonine kinase activity G1/S transition of mitotic cell cycle protein binding nucleus nucleoplasm holo TFIIH complex cytosol nucleotide-excision repair regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein phosphorylation cell cycle adult heart development DNA-dependent ATPase activity RNA polymerase II carboxy-terminal domain kinase activity cyclin-dependent protein kinase activating kinase holoenzyme complex ventricular system development negative regulation of apoptotic process positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription from RNA polymerase II promoter metal ion binding protein N-terminus binding positive regulation of smooth muscle cell proliferation response to calcium ion cyclin-dependent protein serine/threonine kinase activator activity negative regulation of DNA helicase activity uc007nwe.1 uc007nwe.2 
ENSMUST00000021527.15 Prkch ENSMUST00000021527.15 protein kinase C, eta, transcript variant 1 (from RefSeq NM_008856.4) ENSMUST00000021527.1 ENSMUST00000021527.10 ENSMUST00000021527.11 ENSMUST00000021527.12 ENSMUST00000021527.13 ENSMUST00000021527.14 ENSMUST00000021527.2 ENSMUST00000021527.3 ENSMUST00000021527.4 ENSMUST00000021527.5 ENSMUST00000021527.6 ENSMUST00000021527.7 ENSMUST00000021527.8 ENSMUST00000021527.9 KPCL_MOUSE NM_008856 P23298 Pkch Q8K2K8 uc007nwn.1 uc007nwn.2 uc007nwn.3 uc007nwn.4 uc007nwn.5 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in the human gene are associated with susceptibility to cerebral infarction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1- CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation. Interacts with FYN (PubMed:11106751). Interacts with RALA (PubMed:21346190). Interacts with DGKQ (By similarity). Cytoplasm te=Associates with cell membrane during keratinocytes differentiation. Predominantly expressed in lung and skin. The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-independent protein kinase C activity protein binding ATP binding cytoplasm cytosol plasma membrane cell-cell junction protein phosphorylation positive regulation of macrophage derived foam cell differentiation membrane kinase activity phosphorylation transferase activity Ral GTPase binding peptidyl-serine phosphorylation enzyme binding cell differentiation negative regulation of glial cell apoptotic process intracellular signal transduction positive regulation of keratinocyte differentiation metal ion binding positive regulation of B cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity positive regulation of glial cell proliferation protein kinase C signaling regulation of bicellular tight junction assembly uc007nwn.1 uc007nwn.2 uc007nwn.3 uc007nwn.4 uc007nwn.5 
ENSMUST00000021530.8 Hif1a ENSMUST00000021530.8 hypoxia inducible factor 1, alpha subunit, transcript variant 2 (from RefSeq NM_010431.3) ENSMUST00000021530.1 ENSMUST00000021530.2 ENSMUST00000021530.3 ENSMUST00000021530.4 ENSMUST00000021530.5 ENSMUST00000021530.6 ENSMUST00000021530.7 HIF1A_MOUSE NM_010431 O08741 O08993 Q61221 Q61664 Q61665 Q8C681 Q8CC19 Q8CCB6 Q8R385 Q9CYA8 uc007nwq.1 uc007nwq.2 uc007nwq.3 uc007nwq.4 uc007nwq.5 This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid in increased delivery of oxygen to hypoxic regions. The transcription factor also plays a role in the induction of genes involved in cell proliferation and survival, energy metabolism, apoptosis, and glucose and iron metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:15225651, PubMed:17981124, PubMed:22009797). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:15225651, PubMed:17981124, PubMed:22009797). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with NCOA1 and/or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity). Induced by reactive oxygen species (ROS). Interacts with the ARNT; forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371). Interacts with COPS5; the interaction increases the transcriptional activity of HIF1A through increased stability (PubMed:11707426). Interacts with EP300 (via TAZ- type 1 domains); the interaction is stimulated in response to hypoxia and inhibited by CITED2. Interacts with CREBBP (via TAZ-type 1 domains). Interacts with NCOA1, NCOA2, APEX1 and HSP90. Interacts (hydroxylated within the ODD domain) with VHLL (via beta domain); the interaction, leads to polyubiquitination and subsequent HIF1A proteasomal degradation. During hypoxia, sumoylated HIF1A also binds VHL; the interaction promotes the ubiquitination of HIF1A (By similarity). Interacts with SENP1; the interaction desumoylates HIF1A resulting in stabilization and activation of transcription (PubMed:17981124). Interacts (via the ODD domain) with NAA10; the interaction appears not to acetylate HIF1A nor have any affect on protein stability, during hypoxia. Interacts with RWDD3; the interaction enhances HIF1A sumoylation (By similarity). Interacts with TSGA10 (PubMed:16777103). Interacts with HIF3A (PubMed:21546903). Interacts with RORA (via the DNA binding domain); the interaction enhances HIF1A transcription under hypoxia through increasing protein stability. Interaction with PSMA7 inhibits the transactivation activity of HIF1A under both normoxic and hypoxia-mimicking conditions. Interacts with USP20. Interacts with RACK1; promotes HIF1A ubiquitination and proteasome-mediated degradation. Interacts (via N- terminus) with USP19. Interacts with SIRT2. Interacts (deacetylated form) with EGLN1. Interacts with CBFA2T3. Interacts with HSP90AA1 and HSP90AB1. Interacts with DCUN1D1; this interaction increases the interaction between VHL and DCUN1D1. Interacts with HIF1AN (By similarity). Q61221; P35583: Foxa2; NbExp=5; IntAct=EBI-298954, EBI-2893341; Q61221; Q8BIF2: Rbfox3; NbExp=2; IntAct=EBI-298954, EBI-4567146; Q61221; P51450-2: Rorc; NbExp=2; IntAct=EBI-298954, EBI-4422078; Q61221; Q09472: EP300; Xeno; NbExp=2; IntAct=EBI-298954, EBI-447295; Q61221; P40337: VHL; Xeno; NbExp=2; IntAct=EBI-298954, EBI-301246; Q61221-1; P53762: Arnt; NbExp=5; IntAct=EBI-8549331, EBI-78852; Q61221-1; Q6NY15: Tsga10; NbExp=2; IntAct=EBI-8549331, EBI-8549230; Cytoplasm Nucleus Nucleus speckle Note=Colocalizes with HIF3A isoform 2 in the nucleus and speckles (PubMed:21546903). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61221-1; Sequence=Displayed; Name=2; IsoId=Q61221-2; Sequence=VSP_007739; Ubiquitous. Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID) (By similarity). S-nitrosylation of Cys-810 may be responsible for increased recruitment of p300 coactivator necessary for transcriptional activity of HIF-1 complex. Requires phosphorylation for DNA-binding. Phosphorylation at Ser- 247 by CSNK1D/CK1 represses kinase activity and impairs ARNT binding (By similarity). Phosphorylation by GSK3-beta and PLK3 promote degradation by the proteasome (PubMed:20889502). Sumoylated; with SUMO1 under hypoxia (PubMed:15225651, PubMed:17981124). Sumoylation is enhanced through interaction with RWDD3 (By similarity). Both sumoylation and desumoylation seem to be involved in the regulation of its stability during hypoxia (PubMed:15225651, PubMed:17981124). Sumoylation can promote either its stabilization or its VHL-dependent degradation by promoting hydroxyproline-independent HIF1A-VHL complex binding, thus leading to HIF1A ubiquitination and proteasomal degradation (By similarity). Desumoylation by SENP1 increases its stability amd transcriptional activity (PubMed:17981124). There is a disaccord between various publications on the effect of sumoylation and desumoylation on its stability and transcriptional activity (Probable). Acetylation of Lys-545 by ARD1 increases interaction with VHL and stimulates subsequent proteasomal degradation (By similarity). Deacetylation of Lys-719 by SIRT2 increases its interaction with and hydroxylation by EGLN1 thereby inactivating HIF1A activity by inducing its proteasomal degradation (By similarity). Ubiquitinated; in normoxia, following hydroxylation and interaction with VHL. Lys-545 appears to be the principal site of ubiquitination. Clioquinol, the Cu/Zn-chelator, inhibits ubiquitination through preventing hydroxylation at Asn-813. Ubiquitinated by E3 ligase VHL. Deubiquitinated by UCHL1 (By similarity). The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains. In normoxia, is hydroxylated on Pro-402 and Pro-577 in the oxygen- dependent degradation domain (ODD) by EGLN1/PHD2 and EGLN2/PHD1. EGLN3/PHD3 has also been shown to hydroxylate Pro-577. The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Deubiquitinated by USP20. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization (By similarity). In normoxia, is hydroxylated on Asn-813 by HIF1AN, thus abrogating interaction with CREBBP and EP300 and preventing transcriptional activation. Repressed by iron ion, via Fe(2+) prolyl hydroxylase (PHD) enzymes-mediated hydroxylation and subsequent proteasomal degradation. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis blood vessel development response to hypoxia neural crest cell migration epithelial to mesenchymal transition embryonic placenta development B-1 B cell homeostasis vasculature development heart looping p53 binding positive regulation of neuroblast proliferation connective tissue replacement involved in inflammatory response wound healing outflow tract morphogenesis cardiac ventricle morphogenesis DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol lactate metabolic process regulation of glycolytic process regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cellular iron ion homeostasis signal transduction lactation transcription factor binding positive regulation of cell proliferation visual learning response to iron ion regulation of gene expression positive regulation of autophagy vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration positive regulation of receptor biosynthetic process response to muscle activity positive regulation of macroautophagy nuclear body nuclear speck axonal transport of mitochondrion enzyme binding protein kinase binding protein domain specific binding neural fold elevation formation cerebral cortex development cell differentiation negative regulation of ossification negative regulation of bone mineralization positive regulation of vascular endothelial growth factor receptor signaling pathway motile cilium ubiquitin protein ligase binding negative regulation of TOR signaling oxygen homeostasis regulation of transforming growth factor beta2 production collagen metabolic process macromolecular complex histone acetyltransferase binding embryonic hemopoiesis nuclear hormone receptor binding positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of cell proliferation hemoglobin biosynthetic process glucose homeostasis histone deacetylase binding positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration sequence-specific DNA binding regulation of transcription from RNA polymerase II promoter in response to oxidative stress macromolecular complex binding positive regulation of erythrocyte differentiation positive regulation of gluconeogenesis positive regulation of angiogenesis positive regulation of transcription, DNA-templated negative regulation of vasoconstriction negative regulation of growth positive regulation of transcription from RNA polymerase II promoter muscle cell cellular homeostasis positive regulation of hormone biosynthetic process protein heterodimerization activity protein dimerization activity blood vessel morphogenesis digestive tract morphogenesis camera-type eye morphogenesis positive regulation of smooth muscle cell proliferation regulation of catalytic activity cartilage development elastin metabolic process Hsp90 protein binding intestinal epithelial cell maturation response to fungicide epithelial cell differentiation involved in mammary gland alveolus development iris morphogenesis retina vasculature development in camera-type eye positive regulation of transcription from RNA polymerase II promoter in response to hypoxia regulation of thymocyte apoptotic process negative regulation of thymocyte apoptotic process E-box binding cellular response to interleukin-1 cellular response to hypoxia dopaminergic neuron differentiation RNA polymerase II transcription factor complex hypoxia-inducible factor-1alpha signaling pathway positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway positive regulation of mitophagy regulation of aerobic respiration axon cytoplasm negative regulation of reactive oxygen species metabolic process negative regulation of mesenchymal cell apoptotic process uc007nwq.1 uc007nwq.2 uc007nwq.3 uc007nwq.4 uc007nwq.5 
ENSMUST00000021532.6 Snapc1 ENSMUST00000021532.6 small nuclear RNA activating complex, polypeptide 1, transcript variant 7 (from RefSeq NR_184684.1) ENSMUST00000021532.1 ENSMUST00000021532.2 ENSMUST00000021532.3 ENSMUST00000021532.4 ENSMUST00000021532.5 NR_184684 Q8K0S9 SNPC1_MOUSE uc007nwt.1 uc007nwt.2 uc007nwt.3 Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity). Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4 and TBP (By similarity). Nucleus DNA binding nucleus nucleolus snRNA-activating protein complex snRNA transcription from RNA polymerase II promoter snRNA transcription from RNA polymerase III promoter sequence-specific DNA binding uc007nwt.1 uc007nwt.2 uc007nwt.3 
ENSMUST00000021536.9 Atp6v1d ENSMUST00000021536.9 ATPase, H+ transporting, lysosomal V1 subunit D (from RefSeq NM_023721.2) Atp6v1d ENSMUST00000021536.1 ENSMUST00000021536.2 ENSMUST00000021536.3 ENSMUST00000021536.4 ENSMUST00000021536.5 ENSMUST00000021536.6 ENSMUST00000021536.7 ENSMUST00000021536.8 NM_023721 Q3U861 Q3U861_MOUSE uc007nzj.1 uc007nzj.2 uc007nzj.3 Cell projection, cilium Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein Belongs to the V-ATPase D subunit family. centrosome cilium membrane proton-transporting V-type ATPase complex ATPase activity, coupled to transmembrane movement of substances transmembrane transport cilium assembly protein localization to cilium uc007nzj.1 uc007nzj.2 uc007nzj.3 
ENSMUST00000021544.8 Plek2 ENSMUST00000021544.8 pleckstrin 2 (from RefSeq NM_013738.3) ENSMUST00000021544.1 ENSMUST00000021544.2 ENSMUST00000021544.3 ENSMUST00000021544.4 ENSMUST00000021544.5 ENSMUST00000021544.6 ENSMUST00000021544.7 NM_013738 PLEK2_MOUSE Q9WV52 uc007nzl.1 uc007nzl.2 uc007nzl.3 uc007nzl.4 May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. Overexpression of pleckstrin 2 causes large lamellipodia and peripheral ruffle formation. Cell projection, lamellipodium membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Ubiquitous. Most abundant in the thymus, large bowel, small bowel, stomach, and prostate. cytoplasm cytoskeleton plasma membrane membrane actin cytoskeleton organization lamellipodium membrane positive regulation of cell projection organization actin cytoskeleton reorganization phosphatidylinositol-3-phosphate binding intracellular signal transduction cell projection phosphatidylinositol-3,4-bisphosphate binding phosphatidylinositol-3,5-bisphosphate binding uc007nzl.1 uc007nzl.2 uc007nzl.3 uc007nzl.4 
ENSMUST00000021547.8 Zfyve26 ENSMUST00000021547.8 zinc finger, FYVE domain containing 26 (from RefSeq NM_001008550.1) B9EJ71 ENSMUST00000021547.1 ENSMUST00000021547.2 ENSMUST00000021547.3 ENSMUST00000021547.4 ENSMUST00000021547.5 ENSMUST00000021547.6 ENSMUST00000021547.7 Kiaa0321 NM_001008550 Q3TEM9 Q3V1N3 Q5DU37 Q8BY74 Q8CDR8 Q923B4 ZFY26_MOUSE uc007oae.1 uc007oae.2 uc007oae.3 Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity). Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody Note=Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5DU37-1; Sequence=Displayed; Name=2; IsoId=Q5DU37-2; Sequence=VSP_030343; Name=3; IsoId=Q5DU37-3; Sequence=VSP_030342, VSP_030344, VSP_030345, VSP_030346; The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis. Belongs to the ZFYVE26 family. Sequence=BAD90401.1; Type=Erroneous initiation; Evidence=; mitotic cytokinesis double-strand break repair via homologous recombination cytoplasm centrosome microtubule organizing center cytoskeleton DNA repair cellular response to DNA damage stimulus cell cycle lipid binding midbody phosphatidylinositol-3-phosphate binding regulation of cytokinesis metal ion binding cell division uc007oae.1 uc007oae.2 uc007oae.3 
ENSMUST00000021548.12 Rdh12 ENSMUST00000021548.12 retinol dehydrogenase 12, transcript variant 1 (from RefSeq NM_030017.4) ENSMUST00000021548.1 ENSMUST00000021548.10 ENSMUST00000021548.11 ENSMUST00000021548.2 ENSMUST00000021548.3 ENSMUST00000021548.4 ENSMUST00000021548.5 ENSMUST00000021548.6 ENSMUST00000021548.7 ENSMUST00000021548.8 ENSMUST00000021548.9 NM_030017 Q8BYK4 Q91WA5 Q9D1Y4 RDH12_MOUSE uc007oac.1 uc007oac.2 uc007oac.3 uc007oac.4 The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in the human gene are associated with Leber congenital amaurosis type 13, and Retinitis Pigmentosa 53. [provided by RefSeq, Sep 2015]. Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans- retinal. Shows very weak activity toward 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (By similarity). Plays an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838, PubMed:22621924, PubMed:17032653). Has no dehydrogenase activity towards steroids (By similarity). Reaction=all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH; Xref=Rhea:RHEA:25033, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.300; Evidence=; Reaction=11-cis-retinol + NADP(+) = 11-cis-retinal + H(+) + NADPH; Xref=Rhea:RHEA:54912, ChEBI:CHEBI:15378, ChEBI:CHEBI:16066, ChEBI:CHEBI:16302, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Reaction=9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH; Xref=Rhea:RHEA:54916, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78272, ChEBI:CHEBI:78273; Evidence=; Reaction=a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH; Xref=Rhea:RHEA:58336, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142593, ChEBI:CHEBI:142606; Evidence=; Reaction=(E)-non-2-en-1-ol + NADP(+) = (E)-non-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:58332, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142592, ChEBI:CHEBI:142604; Evidence=; Reaction=(Z)-non-6-en-1-ol + NADP(+) = (Z)-non-6-enal + H(+) + NADPH; Xref=Rhea:RHEA:58328, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142591, ChEBI:CHEBI:142603; Evidence=; Reaction=NADP(+) + nonan-1-ol = H(+) + NADPH + nonanal; Xref=Rhea:RHEA:58380, ChEBI:CHEBI:15378, ChEBI:CHEBI:35986, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:84268; Evidence=; Cofactor metabolism; retinol metabolism. Expressed in the inner segments of the photoreceptor in retina. Deficient mice are fertile and developed normally. Deficient mice exhibit normal retinal function at 6 weeks, but they show increased susceptibility to retinal cell apoptosis of both cone and rod photoreceptors induced by high intensity illumination (PubMed:17032653). All- trans-retinol production in inner and outer segments of the photoreceptor is not affected in deficient mice (PubMed:22621924). Shows clear specificity for the pro-S hydrogen on C4 of NADPH and the pro-R hydrogen on C15 of retinols. Belongs to the short-chain dehydrogenases/reductases (SDR) family. photoreceptor inner segment retinol dehydrogenase activity visual perception oxidoreductase activity retinol metabolic process response to stimulus NADP-retinol dehydrogenase activity oxidation-reduction process uc007oac.1 uc007oac.2 uc007oac.3 uc007oac.4 
ENSMUST00000021550.7 Arg2 ENSMUST00000021550.7 arginase type II (from RefSeq NM_009705.3) ARGI2_MOUSE ENSMUST00000021550.1 ENSMUST00000021550.2 ENSMUST00000021550.3 ENSMUST00000021550.4 ENSMUST00000021550.5 ENSMUST00000021550.6 NM_009705 O08691 uc007nzv.1 uc007nzv.2 uc007nzv.3 uc007nzv.4 May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970, PubMed:25009204). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (PubMed:27074721). May play a role in promoting prenatal immune suppression (By similarity). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (By similarity). Reaction=H2O + L-arginine = L-ornithine + urea; Xref=Rhea:RHEA:20569, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:32682, ChEBI:CHEBI:46911; EC=3.5.3.1; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. Nitrogen metabolism; urea cycle; L-ornithine and urea from L- arginine: step 1/1. Homotrimer. Mitochondrion Belongs to the arginase family. urea cycle ureteric bud development adaptive immune response immune system process negative regulation of type 2 immune response arginase activity cytoplasm mitochondrion arginine metabolic process striated muscle contraction regulation of L-arginine import hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines arginine catabolic process to ornithine manganese ion binding negative regulation of tumor necrosis factor production innate immune response negative regulation of striated muscle contraction metal ion binding regulation of interleukin-1 beta secretion nitric-oxide synthase binding negative regulation of nitric-oxide synthase activity negative regulation of macrophage inflammatory protein 1 alpha production negative regulation of chemokine (C-C motif) ligand 4 production negative regulation of chemokine (C-C motif) ligand 5 production negative regulation of defense response to bacterium regulation of reactive oxygen species biosynthetic process negative regulation of tumor necrosis factor secretion negative regulation of interleukin-17 secretion negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of interleukin-13 secretion positive regulation of cellular senescence uc007nzv.1 uc007nzv.2 uc007nzv.3 uc007nzv.4 
ENSMUST00000021552.3 Zfp36l1 ENSMUST00000021552.3 zinc finger protein 36, C3H type-like 1 (from RefSeq NM_007564.5) ENSMUST00000021552.1 ENSMUST00000021552.2 NM_007564 Q543H2 Q543H2_MOUSE Zfp36l1 uc007oal.1 uc007oal.2 uc007oal.3 Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'- untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE- containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes. Nucleus Cytoplasm MAPK cascade P-body mRNA binding nucleus cytoplasm cytosol mRNA catabolic process response to wounding regulation of gene expression regulation of keratinocyte proliferation phosphatidylinositol 3-kinase signaling AU-rich element binding nuclear-transcribed mRNA catabolic process, deadenylation-independent decay regulation of mRNA 3'-end processing cellular response to insulin stimulus mRNA 3'-UTR AU-rich region binding regulation of mRNA stability regulation of keratinocyte differentiation negative regulation of erythrocyte differentiation positive regulation of monocyte differentiation metal ion binding mRNA transport 3'-UTR-mediated mRNA destabilization ERK1 and ERK2 cascade cellular response to cAMP cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to peptide hormone stimulus cellular response to glucocorticoid stimulus cellular response to hypoxia cellular response to transforming growth factor beta stimulus 14-3-3 protein binding positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of keratinocyte apoptotic process positive regulation of intracellular mRNA localization ribonucleoprotein complex uc007oal.1 uc007oal.2 uc007oal.3 
ENSMUST00000021554.16 Actn1 ENSMUST00000021554.16 actinin, alpha 1, transcript variant 1 (from RefSeq NM_134156.3) ACTN1_MOUSE ENSMUST00000021554.1 ENSMUST00000021554.10 ENSMUST00000021554.11 ENSMUST00000021554.12 ENSMUST00000021554.13 ENSMUST00000021554.14 ENSMUST00000021554.15 ENSMUST00000021554.2 ENSMUST00000021554.3 ENSMUST00000021554.4 ENSMUST00000021554.5 ENSMUST00000021554.6 ENSMUST00000021554.7 ENSMUST00000021554.8 ENSMUST00000021554.9 NM_134156 Q7TPR4 uc007oap.1 uc007oap.2 uc007oap.3 uc007oap.4 F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). Homodimer; antiparallel. Interacts with MYOZ2, TTID and LPP. Interacts with DDN (By similarity). Interacts with PSD (PubMed:17298598). Interacts with MICALL2 (PubMed:23100251). Interacts with DNM2 and CTTN. Interacts with PDLIM1. Interacts with PDLIM2. Interacts with PDLIM4 (via PDZ domain) (By similarity). Q7TPR4; Q8K4E0: Alms1; NbExp=4; IntAct=EBI-774010, EBI-6272972; Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line Cell membrane Cell junction Cell projection, ruffle Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle (PubMed:11114196). Colocalizes with PSD in membrane ruffles and central reticular structures (PubMed:17298598). Belongs to the alpha-actinin family. stress fiber ruffle double-stranded RNA binding actin binding integrin binding calcium ion binding protein binding nucleus cytoplasm cytoskeleton actin filament plasma membrane brush border cell-cell junction fascia adherens focal adhesion actin filament organization membrane vinculin binding protein domain specific binding sarcomere Z disc cell junction secretory granule platelet formation ligand-dependent nuclear receptor transcription coactivator activity cortical cytoskeleton cortical cytoskeleton organization dense core granule membrane platelet morphogenesis protein homodimerization activity cell projection dendritic spine ion channel binding metal ion binding focal adhesion assembly actin filament binding actin filament bundle assembly negative regulation of cellular component movement actin filament network formation actin crosslink formation glutamatergic synapse positive regulation of nucleic acid-templated transcription cortical actin cytoskeleton uc007oap.1 uc007oap.2 uc007oap.3 uc007oap.4 
ENSMUST00000021559.14 Erh ENSMUST00000021559.14 ERH mRNA splicing and mitosis factor, transcript variant 1 (from RefSeq NM_007951.5) ENSMUST00000021559.1 ENSMUST00000021559.10 ENSMUST00000021559.11 ENSMUST00000021559.12 ENSMUST00000021559.13 ENSMUST00000021559.2 ENSMUST00000021559.3 ENSMUST00000021559.4 ENSMUST00000021559.5 ENSMUST00000021559.6 ENSMUST00000021559.7 ENSMUST00000021559.8 ENSMUST00000021559.9 Erh NM_007951 Q4FZH7 Q4FZH7_MOUSE uc007oaz.1 uc007oaz.2 uc007oaz.3 uc007oaz.4 May have a role in the cell cycle. Belongs to the E(R) family. cell cycle uc007oaz.1 uc007oaz.2 uc007oaz.3 uc007oaz.4 
ENSMUST00000021564.11 Smoc1 ENSMUST00000021564.11 SPARC related modular calcium binding 1, transcript variant 2 (from RefSeq NM_022316.2) E9QKW2 E9QKW2_MOUSE ENSMUST00000021564.1 ENSMUST00000021564.10 ENSMUST00000021564.2 ENSMUST00000021564.3 ENSMUST00000021564.4 ENSMUST00000021564.5 ENSMUST00000021564.6 ENSMUST00000021564.7 ENSMUST00000021564.8 ENSMUST00000021564.9 NM_022316 Smoc1 uc007obt.1 uc007obt.2 uc007obt.3 uc007obt.4 Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding uc007obt.1 uc007obt.2 uc007obt.3 uc007obt.4 
ENSMUST00000021567.6 Pcnx1 ENSMUST00000021567.6 pecanex 1 (from RefSeq NM_018814.3) ENSMUST00000021567.1 ENSMUST00000021567.2 ENSMUST00000021567.3 ENSMUST00000021567.4 ENSMUST00000021567.5 Kiaa0805 NM_018814 PCX1_MOUSE Pcnx Pcnx1 Pcnxl1 Q6ZQ41 Q9CUU7 Q9QYC1 uc007ocq.1 uc007ocq.2 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QYC1-1; Sequence=Displayed; Name=2; IsoId=Q9QYC1-2; Sequence=VSP_022167; Belongs to the pecanex family. Sequence=AAF21809.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc007ocq.1 uc007ocq.2 
ENSMUST00000021592.16 Cdca7l ENSMUST00000021592.16 cell division cycle associated 7 like, transcript variant 6 (from RefSeq NR_182073.1) CDA7L_MOUSE ENSMUST00000021592.1 ENSMUST00000021592.10 ENSMUST00000021592.11 ENSMUST00000021592.12 ENSMUST00000021592.13 ENSMUST00000021592.14 ENSMUST00000021592.15 ENSMUST00000021592.2 ENSMUST00000021592.3 ENSMUST00000021592.4 ENSMUST00000021592.5 ENSMUST00000021592.6 ENSMUST00000021592.7 ENSMUST00000021592.8 ENSMUST00000021592.9 NR_182073 Q922M5 uc007pid.1 uc007pid.2 uc007pid.3 Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells (By similarity). Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. Interacts with MYC (By similarity). Interacts (via IBM motifs) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (By similarity). Cytoplasm Nucleus Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction (By similarity). Expressed in all tissues but not detected in total brain. Phosphorylation increases its interaction with PSIP1. fibrillar center nucleus nucleolus cytoplasm cytosol regulation of transcription, DNA-templated positive regulation of cell proliferation uc007pid.1 uc007pid.2 uc007pid.3 
ENSMUST00000021595.10 Psmc1 ENSMUST00000021595.10 protease (prosome, macropain) 26S subunit, ATPase 1 (from RefSeq NM_008947.3) ENSMUST00000021595.1 ENSMUST00000021595.2 ENSMUST00000021595.3 ENSMUST00000021595.4 ENSMUST00000021595.5 ENSMUST00000021595.6 ENSMUST00000021595.7 ENSMUST00000021595.8 ENSMUST00000021595.9 NM_008947 Psmc1 Q542I9 Q542I9_MOUSE uc007osn.1 uc007osn.2 uc007osn.3 uc007osn.4 uc007osn.5 Cytoplasm Nucleus Belongs to the AAA ATPase family. nucleotide binding proteasome complex ATP binding nucleus nucleoplasm cytoplasm cytosol hydrolase activity TBP-class protein binding protein catabolic process proteasome-activating ATPase activity positive regulation of proteasomal protein catabolic process uc007osn.1 uc007osn.2 uc007osn.3 uc007osn.4 uc007osn.5 
ENSMUST00000021596.9 Nrde2 ENSMUST00000021596.9 nrde-2 necessary for RNA interference, domain containing, transcript variant 5 (from RefSeq NR_165261.1) E9QKV8 ENSMUST00000021596.1 ENSMUST00000021596.2 ENSMUST00000021596.3 ENSMUST00000021596.4 ENSMUST00000021596.5 ENSMUST00000021596.6 ENSMUST00000021596.7 ENSMUST00000021596.8 NRDE2_MOUSE NR_165261 Q80XC6 Q8R3D7 Q99LT9 uc007oso.1 uc007oso.2 uc007oso.3 uc007oso.4 Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (By similarity). U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre- mRNA and plays an important role in centrosome maturation, integrity and function during mitosis (By similarity). Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites (By similarity). Plays a role in DNA damage response (By similarity). Interacts with MTREX; the interaction is direct and stabilizes NRDE2 (By similarity). Interacts with EXOSC10, EFTUD2 and EIF4A3 (By similarity). Nucleus speckle Nucleus, nucleolus Nucleus, nucleoplasm Nucleus The MID/MTR4-interacting domain is necessary and sufficient to mediate interaction with MTREX. Belongs to the NRDE2 family. Sequence=AAH25577.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH51175.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BY182441; Type=Frameshift; Evidence=; molecular_function nucleoplasm nucleolus RNA processing RNA interference nuclear speck chromatin silencing by small RNA negative regulation of RNA catabolic process uc007oso.1 uc007oso.2 uc007oso.3 uc007oso.4 
ENSMUST00000021603.9 Fbln5 ENSMUST00000021603.9 fibulin 5, transcript variant 14 (from RefSeq NR_182218.1) Dance ENSMUST00000021603.1 ENSMUST00000021603.2 ENSMUST00000021603.3 ENSMUST00000021603.4 ENSMUST00000021603.5 ENSMUST00000021603.6 ENSMUST00000021603.7 ENSMUST00000021603.8 FBLN5_MOUSE NR_182218 Q541Z7 Q9WVH9 uc007otp.1 uc007otp.2 uc007otp.3 uc007otp.4 Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (By similarity). Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:11805835). May act as an adapter that mediates the interaction between FBN1 and ELN (By similarity). Homodimer. Monomer, homodimerizes in presence of Ca(2+). Interacts with ELN (By similarity). Interacts (via N-terminus) with the integrins ITGAV/ITGB3, ITGAV/ITGB5 and ITGA9/ITGB1 (PubMed:11805835). Interacts with FBN1 (via N-terminal domain). Forms a ternary complex with ELN and FBN1 (By similarity). Interacts with EFEMP2 with moderate affinity (By similarity). Secreted Secreted, extracellular space, extracellular matrix Note=co-localizes with ELN in elastic fibers. N-glycosylated. Mice survive to adulthood, but have a tortuous aorta with loss of compliance, severe emphisema and loose skin. They exhibit a severely disorganized elastic fiber system throughout the body. Belongs to the fibulin family. regulation of cell growth integrin binding calcium ion binding extracellular region extracellular space cell adhesion protein C-terminus binding extracellular matrix constituent conferring elasticity extracellular matrix organization protein localization to cell surface protein homodimerization activity secretion elastic fiber assembly regulation of removal of superoxide radicals elastic fiber uc007otp.1 uc007otp.2 uc007otp.3 uc007otp.4 
ENSMUST00000021605.14 Trip11 ENSMUST00000021605.14 thyroid hormone receptor interactor 11 (from RefSeq NM_028446.1) E9Q512 E9Q512_MOUSE ENSMUST00000021605.1 ENSMUST00000021605.10 ENSMUST00000021605.11 ENSMUST00000021605.12 ENSMUST00000021605.13 ENSMUST00000021605.2 ENSMUST00000021605.3 ENSMUST00000021605.4 ENSMUST00000021605.5 ENSMUST00000021605.6 ENSMUST00000021605.7 ENSMUST00000021605.8 ENSMUST00000021605.9 NM_028446 Trip11 uc007ott.1 uc007ott.2 uc007ott.3 uc007ott.4 Membrane ; Peripheral membrane protein inner acrosomal membrane acrosomal membrane outer acrosomal membrane ventricular septum development chondrocyte differentiation involved in endochondral bone morphogenesis protein binding nucleus endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cis-Golgi network protein glycosylation Golgi organization nuclear speck cartilage development inner ear receptor stereocilium organization bone development Golgi ribbon formation vesicle tethering to Golgi uc007ott.1 uc007ott.2 uc007ott.3 uc007ott.4 
ENSMUST00000021606.12 Atxn3 ENSMUST00000021606.12 ataxin 3, transcript variant 1 (from RefSeq NM_029705.3) ATX3_MOUSE ENSMUST00000021606.1 ENSMUST00000021606.10 ENSMUST00000021606.11 ENSMUST00000021606.2 ENSMUST00000021606.3 ENSMUST00000021606.4 ENSMUST00000021606.5 ENSMUST00000021606.6 ENSMUST00000021606.7 ENSMUST00000021606.8 ENSMUST00000021606.9 Mjd NM_029705 Q9CVD2 uc007otv.1 uc007otv.2 uc007otv.3 uc007otv.4 Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:21855799). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (By similarity). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence= Interacts with STUB1/CHIP (when monoubiquitinated) (PubMed:21855799). Interacts with DNA repair proteins RAD23A and RAD23B (By similarity). Interacts with BECN1 (via its poly-Gln domain) (PubMed:28445460). Interacts with PRKN, UBR2, VCP and tubulin (By similarity). Nucleus matrix Nucleus Lysosome membrane ; Peripheral membrane protein Note=Predominantly nuclear, but not exclusively, inner nuclear matrix. Recruited to lysosomal membrane in response to amino acid deprivation by the RagA/RRAGA-RagB/RRAGB complex. The UIM domains bind ubiquitin and interact with various E3 ubiquitin-protein ligase, such as STUB1/CHIP. They are essential to limit the length of ubiquitin chains (PubMed:21855799). Monoubiquitinated by UBE2W, possibly leading to activate the deubiquitinating enzyme activity (By similarity). microtubule cytoskeleton organization RNA polymerase II regulatory region DNA binding histone deacetylase activity thiol-dependent ubiquitin-specific protease activity protein binding nucleus nucleolus cytoplasm mitochondrial matrix cytosol plasma membrane proteolysis ubiquitin-dependent protein catabolic process misfolded or incompletely synthesized protein catabolic process peptidase activity cysteine-type peptidase activity regulation of cell-substrate adhesion protein deubiquitination hydrolase activity actin cytoskeleton organization ubiquitin protein ligase binding mitochondrial membrane cellular response to heat monoubiquitinated protein deubiquitination exploration behavior thiol-dependent ubiquitinyl hydrolase activity nuclear inclusion body identical protein binding proteasome-mediated ubiquitin-dependent protein catabolic process intermediate filament cytoskeleton organization ATPase binding Lys63-specific deubiquitinase activity protein K63-linked deubiquitination histone H3 deacetylation protein K48-linked deubiquitination cellular response to misfolded protein positive regulation of ERAD pathway protein localization to cytosolic proteasome complex involved in ERAD pathway Lys48-specific deubiquitinase activity endoplasmic reticulum membrane uc007otv.1 uc007otv.2 uc007otv.3 uc007otv.4 
ENSMUST00000021607.9 Lgmn ENSMUST00000021607.9 legumain, transcript variant 1 (from RefSeq NM_011175.4) ENSMUST00000021607.1 ENSMUST00000021607.2 ENSMUST00000021607.3 ENSMUST00000021607.4 ENSMUST00000021607.5 ENSMUST00000021607.6 ENSMUST00000021607.7 ENSMUST00000021607.8 LGMN_MOUSE NM_011175 O89017 Prsc1 uc007ouf.1 uc007ouf.2 uc007ouf.3 This gene encodes a member of the cysteine peptidase family C13 that plays an important role in the endosome/lysosomal degradation system. The encoded inactive preproprotein undergoes autocatalytic removal of the C-terminal inhibitory propeptide to generate the active endopeptidase that cleaves protein substrates on the C-terminal side of asparagine residues. Mice lacking the encoded protein exhibit defects in the lysosomal processing of proteins resulting in their accumulation in the lysosomes, and develop symptoms resembling hemophagocytic lymphohistiocytosis. [provided by RefSeq, Aug 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ000990.1, AF044266.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Has a strict specificity for hydrolysis of asparaginyl bonds (PubMed:24407422, PubMed:9742219, PubMed:9891971). Can also cleave aspartyl bonds slowly, especially under acidic conditions (PubMed:24407422, PubMed:9742219, PubMed:9891971). Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (PubMed:37347855). Required for normal lysosomal protein degradation in renal proximal tubules (PubMed:17350006, PubMed:21292981). Required for normal degradation of internalized EGFR (PubMed:21292981). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (PubMed:21292981). Reaction=Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.; EC=3.4.22.34; Evidence= Inhibited by cystatin-C. pH dependence: Optimum pH is 6. ; Homodimer before autocatalytic removal of the propeptide (PubMed:24407422). Monomer after autocatalytic processing (PubMed:24407422). May interact with integrins (By similarity). Lysosome Detected in kidney proximal tubules (at protein level). Ubiquitous. Particularly abundant in kidney and placenta. In the zymogen form, the uncleaved propeptide blocks access to the active site. Glycosylated. Activated by autocatalytic processing at pH 4. Young mice initially display no obvious phenotype, but fail to gain weight normally. Mutant mice display pale kidneys with abnormal proliferation of proximal tubule cells, proximal tubule hyperplasia and develop kidney interstitium fibrosis. After 6 months, mutant mice display a decreased glomerular filtration rate, increased plasma creatinine levels and proteinuria. Glomerular lysosomes do not show a generalized defect in protein catabolism. Instead they show defects in the degradation of a set of target proteins, including EGFR. Belongs to the peptidase C13 family. renal system process cysteine-type endopeptidase activity extracellular region cytoplasm lysosome late endosome proteolysis vacuolar protein processing memory peptidase activity cysteine-type peptidase activity positive regulation of cell proliferation associative learning response to acidic pH negative regulation of gene expression hydrolase activity receptor catabolic process cellular response to hepatocyte growth factor stimulus negative regulation of multicellular organism growth negative regulation of neuron apoptotic process apical part of cell positive regulation of mitotic cell cycle perinuclear region of cytoplasm proteolysis involved in cellular protein catabolic process cellular response to calcium ion positive regulation of monocyte chemotaxis dendritic spine organization activation of cysteine-type endopeptidase activity self proteolysis positive regulation of long-term synaptic potentiation negative regulation of ERBB signaling pathway cellular response to beta-amyloid positive regulation of endothelial cell chemotaxis uc007ouf.1 uc007ouf.2 uc007ouf.3 
ENSMUST00000021610.7 Chga ENSMUST00000021610.7 chromogranin A (from RefSeq NM_007693.2) CMGA_MOUSE ENSMUST00000021610.1 ENSMUST00000021610.2 ENSMUST00000021610.3 ENSMUST00000021610.4 ENSMUST00000021610.5 ENSMUST00000021610.6 NM_007693 P26339 uc007oui.1 uc007oui.2 uc007oui.3 uc007oui.4 This gene encodes a member of the granin family of acidic secretory glycoproteins that are expressed in endocrine cells and neurons. The encoded preproprotein undergoes proteolytic processing to generate multiple functions peptides including pancreastatin, catestatin and serpinin. The encoded protein plays important roles in the neuroendocrine system including regulated secretion of peptide hormones and neurotransmitters. Mice lacking the encoded protein exhibit elevated blood pressure which can be rescued by transgenic expression of the human ortholog. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M64278.1, AK144504.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (PubMed:21436258). Pyroglutaminated (pGlu)-serpinin exerts an antiapoptotic effect on cells exposed to oxidative stress (PubMed:21537909). Self-interacts; self-assembly is promoted in vitro by chondroitin sulfate attachment which occurs at mildly acidic pH conditions (By similarity). Interacts with SCG3; this interaction is optimal in conditions mimicking the lumenal milieu of the trans-Golgi network, i.e. pH 5.5 and 10 mM Ca(+2) (PubMed:12388744). P26339; P00441: SOD1; Xeno; NbExp=5; IntAct=EBI-990900, EBI-990792; Cytoplasmic vesicle, secretory vesicle Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle Secreted Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. [Serpinin]: Secreted Cytoplasmic vesicle, secretory vesicle Note=Pyroglutaminated serpinin localizes to secretory vesicle. O-glycosylated; contains chondroitin sulfate (CS). CS attachment is pH-dependent, being observed at mildly acidic conditions of pH 5 but not at neutral pH, and promotes self-assembly in vitro. [Serpinin]: Mass=2864.4; Method=MALDI; Evidence=; [Serpinin]: Mass=2864.5; Method=MALDI; Evidence=; [p-Glu serpinin precursor]: Mass=2532.4; Method=MALDI; Note=With pyrrolidone carboxylic acid at Gln-438.; Evidence=; Binds calcium with a low-affinity. Belongs to the chromogranin/secretogranin protein family. positive regulation of protein phosphorylation regulation of the force of heart contraction mast cell chemotaxis protein binding extracellular region extracellular space organelle organization membrane transport vesicle secretory granule transport vesicle membrane cytoplasmic vesicle mast cell cytokine production protein localization to secretory granule negative regulation of catecholamine secretion chromaffin granule mast cell granule mast cell degranulation positive regulation of cAMP-mediated signaling mast cell activation perinuclear region of cytoplasm defense response to Gram-negative bacterium defense response to Gram-positive bacterium regulation of cytosolic calcium ion concentration positive regulation of cardiac muscle contraction adrenergic receptor signaling pathway involved in cardiac muscle relaxation positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway negative regulation of neuron death positive regulation of relaxation of cardiac muscle positive regulation of dense core granule biogenesis uc007oui.1 uc007oui.2 uc007oui.3 uc007oui.4 
ENSMUST00000021617.14 Asb2 ENSMUST00000021617.14 ankyrin repeat and SOCS box-containing 2, transcript variant 1 (from RefSeq NM_023049.1) ASB2_MOUSE Asb2 ENSMUST00000021617.1 ENSMUST00000021617.10 ENSMUST00000021617.11 ENSMUST00000021617.12 ENSMUST00000021617.13 ENSMUST00000021617.2 ENSMUST00000021617.3 ENSMUST00000021617.4 ENSMUST00000021617.5 ENSMUST00000021617.6 ENSMUST00000021617.7 ENSMUST00000021617.8 ENSMUST00000021617.9 NM_023049 Q8K0L0 Q9CTH4 Q9WV73 uc007ove.1 uc007ove.2 Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Mediates Notch-induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2 (By similarity). Required during embryonic heart development for complete heart looping (PubMed:32179481). Required for cardiomyocyte differentiation (By similarity). [Isoform 1]: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA (PubMed:26343497). Also targets DES for proteasomal degradation (PubMed:26343497). Acts as a negative regulator of skeletal muscle mass (PubMed:27182554). [Isoform 2]: Targets filamins FLNA and FLNB for proteasomal degradation (PubMed:23632887). This leads to enhanced adhesion of hematopoietic cells to fibronectin (By similarity). Required for FLNA degradation in immature cardiomyocytes which is necessary for actin cytoskeleton remodeling, leading to proper organization of myofibrils and function of mature cardiomyocytes (PubMed:29374072). Required for degradation of FLNA and FLNB in immature dendritic cells (DC) which enhances immature DC migration by promoting DC podosome formation and DC-mediated degradation of the extracellular matrix (PubMed:23632887). Does not promote proteasomal degradation of tyrosine-protein kinases JAK1 or JAK2 in hematopoietic cells (By similarity). Protein modification; protein ubiquitination. Component of a probable ECS E3 ubiquitin-protein ligase complex which contains CUL5, either RBX1 or RNF7/RBX2, Elongin BC complex (ELOB and ELOC) and ASB2. Interacts with SKP2. Through its interaction with SKP2, likely to bridge the formation of dimeric E3- ubiquitin-protein ligase complexes composed of an ECS complex and an SCF(SKP2) complex. Interacts with JAK2; the interaction targets JAK2 for Notch-mediated proteasomal degradation. Interacts with TCF3/E2A; the interaction is mediated by SKP2 and targets TCF3 for Notch-mediated proteasomal degradation. [Isoform 1]: Interacts with DES. Cytoplasm, cytoskeleton, stress fiber [Isoform 1]: Cytoplasm, myofibril, sarcomere, Z line Note=Localizes to the Z line in cardiomyocytes. Event=Alternative splicing; Named isoforms=2; Name=1 ; Synonyms=ASB2beta ; IsoId=Q8K0L0-1; Sequence=Displayed; Name=2 ; Synonyms=ASB2alpha ; IsoId=Q8K0L0-2; Sequence=VSP_052025, VSP_052026; Highest expression in muscle, heart and spleen (PubMed:11111040). Highly expressed in cells of the first and second heart fields in the developing embryonic heart (PubMed:32179481). At 9.5 dpc, robust expression predominantly in the left and right ventricles (RV) and to a lower extent in inflow and outflow tracts (PubMed:32179481). At 10.5 and 11.5 dpc, expression is restricted to the myocardium with no expression observed in the endocardium (PubMed:32179481). [Isoform 1]: Not expressed in immature dendritic cells (PubMed:23632887). Highly expressed in adult skeletal muscle with very low levels in adult bone marrow (PubMed:29374072). [Isoform 2]: Expressed in immature dendritic cells and in primary dendritic cells derived from the spleen (PubMed:23632887). Highly expressed in adult bone marrow with negligible levels in adult skeletal muscle (PubMed:29374072). Expressed at higher levels in T helper type 2 (Th2) cells than in regulatory T (Treg) cells, type 1 helper T (Th1) cells and T helper 17 (Th17) cells (PubMed:31175139). [Isoform 1]: Very low levels found in the developing heart at 9.5 dpc when isoform 2 is the predominant isoform (PubMed:29374072, PubMed:32179481). Expression increases from 11.5 dpc and is the predominant isoform in adult heart (PubMed:29374072, PubMed:32179481). [Isoform 2]: Barely detectable in bone marrow cells but levels progressively increase as cells differentiate into immature dendritic cells and are down-regulated after dendritic cell maturation (PubMed:23632887). Highly expressed in the developing heart at 9.5 dpc when isoform 1 levels are very low (PubMed:29374072). Levels increase up to 11.5 dpc and fall in the adult heart (PubMed:29374072). Repressed by FST in 6-month-old mice but no effect is seen in 24-month-old mice (PubMed:27182554). Expression is increased 4-fold 3 days after denervation, becomes suppressed by approximately 75% 7 days after denervation, and eventually resolves to baseline by 28 days after denervation (PubMed:27182554). The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. [Isoform 2]: Both the N-terminus and ANK repeats 1 to 10 are necessary for interaction with filamins. [Isoform 1]: The UIM domain is required for monoubiquitination. [Isoform 1]: Monoubiquitinated. [Isoform 2]: Not monoubiquitinated. [Isoform 2]: Phosphorylation at Ser-371 is required for association with FLNA and subsequent FLNA degradation. Embryonic lethality with death occurring in utero around 9.5 dpc (PubMed:29374072). Embryos display defects in vascular development and hematopoiesis and increased protein levels of Flna in the heart (PubMed:29374072). Conditional knockout in the whole heart and in the first heart field results in pericardial edema and embryonic lethality (PubMed:32179481). Conditional knockout in the embryonic heart results in impaired heart looping, abnormal expression of Flna expression which is expanded to include the myocardial layer and increased expression of Smad2 (PubMed:32179481). [Isoform 2]: Conditional knockout in hematopoietic stem and progenitor cells results in increased protein levels of Flna and Flnb in immature dendritic cells (PubMed:23632887). Conditional knockout in hematopoietic cells reduces tumor development in a mouse model of colitis-associated tumorigenesis with reduced numbers of T helper type 2 (Th2) cells and regulatory T (Treg) cells and increased numbers of type 1 helper T (Th1) cells and T helper 17 (Th17) cells in the colonic mucosa of tumor-bearing mice (PubMed:31175139). Belongs to the ankyrin SOCS box (ASB) family. Sequence=AAD38809.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ubiquitin ligase complex protein polyubiquitination ubiquitin-dependent protein catabolic process protein ubiquitination Cul5-RING ubiquitin ligase complex intracellular signal transduction skeletal muscle cell differentiation myoblast differentiation ubiquitin protein ligase activity uc007ove.1 uc007ove.2 
ENSMUST00000021620.13 Otub2 ENSMUST00000021620.13 OTU domain, ubiquitin aldehyde binding 2, transcript variant 2 (from RefSeq NM_026580.5) ENSMUST00000021620.1 ENSMUST00000021620.10 ENSMUST00000021620.11 ENSMUST00000021620.12 ENSMUST00000021620.2 ENSMUST00000021620.3 ENSMUST00000021620.4 ENSMUST00000021620.5 ENSMUST00000021620.6 ENSMUST00000021620.7 ENSMUST00000021620.8 ENSMUST00000021620.9 NM_026580 OTUB2_MOUSE Q3TUZ2 Q9CQX0 Q9D4K8 uc007ovg.1 uc007ovg.2 uc007ovg.3 uc007ovg.4 Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Belongs to the peptidase C65 family. thiol-dependent ubiquitin-specific protease activity nucleus proteolysis peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity NEDD8-specific protease activity protein K11-linked deubiquitination thiol-dependent ubiquitinyl hydrolase activity ubiquitin binding protein K63-linked deubiquitination protein K48-linked deubiquitination uc007ovg.1 uc007ovg.2 uc007ovg.3 uc007ovg.4 
ENSMUST00000021628.4 Akr1c21 ENSMUST00000021628.4 aldo-keto reductase family 1, member C21 (from RefSeq NM_029901.2) AK1CL_MOUSE ENSMUST00000021628.1 ENSMUST00000021628.2 ENSMUST00000021628.3 NM_029901 Q6P8V0 Q91WR5 Q9CX32 uc007pjr.1 uc007pjr.2 uc007pjr.3 NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3- alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha-hydroxysteroids, 17- ketosteroids, 3-alpha hydroxysteroids and 3-ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17-alpha-hydroxysteroids. Likewise, reduction of 3- ketosteroids yields only 3-alpha-hydroxysteroids. Reaction=androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH; Xref=Rhea:RHEA:20377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:16032, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.209; Evidence= Reaction=androsterone + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:20381, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:16032, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.209; Evidence= Inhibited by high concentrations of substrate. Kinetic parameters: KM=1.8 uM for NADP KM=19 uM for androstenedione KM=0.5 uM for 5-beta-pregnane-3-alpha,20-alpha-diol ; KM=0.5 uM for 5-beta-pregnane-3,20-dione ; KM=0.6 uM for epitestosterone KM=0.3 uM for androst-4-ene-3,17-dione pH dependence: Optimum pH is 10.0. Monomer. Cytoplasm Detected in kidney and brain. Belongs to the aldo/keto reductase family. alditol:NADP+ 1-oxidoreductase activity aldo-keto reductase (NADP) activity steroid binding cytoplasm cytosol lipid metabolic process steroid biosynthetic process alcohol dehydrogenase (NADP+) activity steroid metabolic process steroid dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor phenanthrene 9,10-monooxygenase activity carboxylic acid binding bile acid binding steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor androsterone dehydrogenase activity 5alpha-androstane-3beta,17beta-diol dehydrogenase activity androsterone dehydrogenase (B-specific) activity ketosteroid monooxygenase activity trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity oxidation-reduction process NADP+ binding NADPH binding 17-beta-ketosteroid reductase activity 17-beta-hydroxysteroid dehydrogenase (NADP+) activity lithocholic acid binding uc007pjr.1 uc007pjr.2 uc007pjr.3 
ENSMUST00000021630.15 Akr1c6 ENSMUST00000021630.15 aldo-keto reductase family 1, member C6, transcript variant 1 (from RefSeq NM_030611.4) Akr1c6 ENSMUST00000021630.1 ENSMUST00000021630.10 ENSMUST00000021630.11 ENSMUST00000021630.12 ENSMUST00000021630.13 ENSMUST00000021630.14 ENSMUST00000021630.2 ENSMUST00000021630.3 ENSMUST00000021630.4 ENSMUST00000021630.5 ENSMUST00000021630.6 ENSMUST00000021630.7 ENSMUST00000021630.8 ENSMUST00000021630.9 NM_030611 Q3UEM0 Q3UEM0_MOUSE uc007pjo.1 uc007pjo.2 uc007pjo.3 Belongs to the aldo/keto reductase family. oxidoreductase activity oxidation-reduction process uc007pjo.1 uc007pjo.2 uc007pjo.3 
ENSMUST00000021632.5 Akr1c12 ENSMUST00000021632.5 aldo-keto reductase family 1, member C12 (from RefSeq NM_013777.2) Akr1c12 Akra ENSMUST00000021632.1 ENSMUST00000021632.2 ENSMUST00000021632.3 ENSMUST00000021632.4 NM_013777 Q9JLI0 Q9JLI0_MOUSE uc007pjn.1 uc007pjn.2 uc007pjn.3 Belongs to the aldo/keto reductase family. alditol:NADP+ 1-oxidoreductase activity aldo-keto reductase (NADP) activity cytosol prostaglandin metabolic process xenobiotic metabolic process alcohol dehydrogenase (NADP+) activity steroid metabolic process steroid dehydrogenase activity oxidoreductase activity bile acid binding progesterone metabolic process daunorubicin metabolic process doxorubicin metabolic process androsterone dehydrogenase activity ketosteroid monooxygenase activity oxidation-reduction process uc007pjn.1 uc007pjn.2 uc007pjn.3 
ENSMUST00000021634.4 Akr1c13 ENSMUST00000021634.4 aldo-keto reductase family 1, member C13, transcript variant 1 (from RefSeq NM_013778.3) AK1CD_MOUSE ENSMUST00000021634.1 ENSMUST00000021634.2 ENSMUST00000021634.3 NM_013778 Q8VC28 Q9D7R9 Q9R0M9 uc007pjl.1 uc007pjl.2 uc007pjl.3 uc007pjl.4 Catalyzes the dehydrogenation of 17-beta-hydroxysteroids. May also exhibit significant activity with a variety of cyclic and alicyclic alcohols. Uses both NAD and NADP, but the activity is much greater with NAD than with NADP (By similarity). Belongs to the aldo/keto reductase family. alditol:NADP+ 1-oxidoreductase activity aldo-keto reductase (NADP) activity cytosol prostaglandin metabolic process xenobiotic metabolic process alcohol dehydrogenase (NADP+) activity steroid metabolic process steroid dehydrogenase activity oxidoreductase activity bile acid binding progesterone metabolic process daunorubicin metabolic process doxorubicin metabolic process androsterone dehydrogenase activity ketosteroid monooxygenase activity oxidation-reduction process uc007pjl.1 uc007pjl.2 uc007pjl.3 uc007pjl.4 
ENSMUST00000021635.9 Akr1c18 ENSMUST00000021635.9 aldo-keto reductase family 1, member C18, transcript variant 1 (from RefSeq NM_134066.3) AKC1H_MOUSE ENSMUST00000021635.1 ENSMUST00000021635.2 ENSMUST00000021635.3 ENSMUST00000021635.4 ENSMUST00000021635.5 ENSMUST00000021635.6 ENSMUST00000021635.7 ENSMUST00000021635.8 NM_134066 Q8K023 Q99N44 uc007pjj.1 uc007pjj.2 uc007pjj.3 Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). Reaction=(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) = 17alpha- hydroxyprogesterone + H(+) + NADPH; Xref=Rhea:RHEA:15857, ChEBI:CHEBI:15378, ChEBI:CHEBI:16418, ChEBI:CHEBI:17252, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.149; Reaction=(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha- hydroxyprogesterone + H(+) + NADH; Xref=Rhea:RHEA:15853, ChEBI:CHEBI:15378, ChEBI:CHEBI:16418, ChEBI:CHEBI:17252, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.149; Monomer. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K023-1; Sequence=Displayed; Name=2; IsoId=Q8K023-2; Sequence=VSP_014039; Belongs to the aldo/keto reductase family. retinal dehydrogenase activity alditol:NADP+ 1-oxidoreductase activity aldo-keto reductase (NADP) activity retinol dehydrogenase activity nucleus cytoplasm cytosol prostaglandin metabolic process progesterone catabolic process G-protein coupled receptor signaling pathway female pregnancy parturition alcohol dehydrogenase (NADP+) activity steroid metabolic process positive regulation of cell proliferation positive regulation of cell death steroid dehydrogenase activity farnesol catabolic process oxidoreductase activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor phenanthrene 9,10-monooxygenase activity bile acid binding cellular response to reactive oxygen species dihydrotestosterone 17-beta-dehydrogenase activity progesterone metabolic process retinal metabolic process daunorubicin metabolic process doxorubicin metabolic process geranylgeranyl reductase activity ketoreductase activity 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity androsterone dehydrogenase activity ketosteroid monooxygenase activity delta4-3-oxosteroid 5beta-reductase activity regulation of retinoic acid receptor signaling pathway regulation of steroid biosynthetic process positive regulation of protein kinase B signaling oxidation-reduction process testosterone biosynthetic process cellular response to cadmium ion cellular response to calcium ion cellular response to follicle-stimulating hormone stimulus cellular response to prostaglandin stimulus cellular response to corticosteroid stimulus cellular response to testosterone stimulus cellular response to jasmonic acid stimulus cellular response to transforming growth factor beta stimulus cellular response to prostaglandin D stimulus cellular response to gonadotropin-releasing hormone negative regulation of retinoic acid biosynthetic process cellular response to forskolin cellular response to prolactin regulation of testosterone biosynthetic process positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process uc007pjj.1 uc007pjj.2 uc007pjj.3 
ENSMUST00000021639.8 Tubal3 ENSMUST00000021639.8 tubulin, alpha-like 3, transcript variant 4 (from RefSeq NM_001426391.1) B9EJS3 ENSMUST00000021639.1 ENSMUST00000021639.2 ENSMUST00000021639.3 ENSMUST00000021639.4 ENSMUST00000021639.5 ENSMUST00000021639.6 ENSMUST00000021639.7 NM_001426391 Q3UX10 TBAL3_MOUSE uc007pjg.1 uc007pjg.2 uc007pjg.3 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Cytoplasm, cytoskeleton The MREC motif may be critical for tubulin autoregulation. Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility. Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity). Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle GTPase activity structural constituent of cytoskeleton GTP binding cytoplasm cytoskeleton microtubule microtubule-based process uc007pjg.1 uc007pjg.2 uc007pjg.3 
ENSMUST00000021641.8 Tshz3 ENSMUST00000021641.8 teashirt zinc finger family member 3 (from RefSeq NM_172298.3) A0A0R4J017 A0A0R4J017_MOUSE ENSMUST00000021641.1 ENSMUST00000021641.2 ENSMUST00000021641.3 ENSMUST00000021641.4 ENSMUST00000021641.5 ENSMUST00000021641.6 ENSMUST00000021641.7 NM_172298 Tshz3 uc009gkj.1 uc009gkj.2 uc009gkj.3 Nucleus Belongs to the teashirt C2H2-type zinc-finger protein family. nucleic acid binding DNA binding chromatin binding nucleus nucleoplasm regulation of gene expression negative regulation of transcription, DNA-templated uc009gkj.1 uc009gkj.2 uc009gkj.3 
ENSMUST00000021646.6 Papln ENSMUST00000021646.6 papilin, proteoglycan-like sulfated glycoprotein, transcript variant 2 (from RefSeq NM_130887.3) A2RTE8 B2RQC4 ENSMUST00000021646.1 ENSMUST00000021646.2 ENSMUST00000021646.3 ENSMUST00000021646.4 ENSMUST00000021646.5 NM_130887 PPN_MOUSE Q99JQ8 Q9EPX2 uc007odr.1 uc007odr.2 uc007odr.3 uc007odr.4 uc007odr.5 Secreted Belongs to the papilin family. serine-type endopeptidase inhibitor activity extracellular matrix structural constituent extracellular region basement membrane proteolysis peptidase activity negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc007odr.1 uc007odr.2 uc007odr.3 uc007odr.4 uc007odr.5 
ENSMUST00000021649.8 Acot2 ENSMUST00000021649.8 acyl-CoA thioesterase 2 (from RefSeq NM_134188.3) ACOT2_MOUSE ENSMUST00000021649.1 ENSMUST00000021649.2 ENSMUST00000021649.3 ENSMUST00000021649.4 ENSMUST00000021649.5 ENSMUST00000021649.6 ENSMUST00000021649.7 Mte1 NM_134188 Q3T9C9 Q9QYR9 uc011yor.1 uc011yor.2 uc011yor.3 uc011yor.4 Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:25114170). Displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:25114170). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (PubMed:25114170). Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence=; Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=; Reaction=H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate; Xref=Rhea:RHEA:30139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30140; Evidence=; Reaction=eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+); Xref=Rhea:RHEA:40147, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32360, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40148; Evidence=; Reaction=decanoyl-CoA + H2O = CoA + decanoate + H(+); Xref=Rhea:RHEA:40059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40060; Evidence=; Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40140; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+); Xref=Rhea:RHEA:40131, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40132; Evidence=; Reaction=(9E)-octadecenoyl-CoA + H2O = (9E)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40723, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30825, ChEBI:CHEBI:57287, ChEBI:CHEBI:77537; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40724; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+); Xref=Rhea:RHEA:40143, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40144; Evidence=; Lipid metabolism; fatty acid metabolism. Monomer. Mitochondrion matrix Highly expressed in brown and white adipose tissue, muscle, heart, kidney, lung, adrenal gland and spleen; weakly expressed in intestine, testis and brain. In the liver, by peroxisome proliferator (Clofibrate) treatment, via the peroxisome proliferator-activated receptors (PPARs) or fasting for 24 hours. Belongs to the C/M/P thioester hydrolase family. very long-chain fatty acid metabolic process response to hypoxia long-chain fatty acid metabolic process mitochondrion mitochondrial matrix lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process palmitoyl-CoA hydrolase activity hydrolase activity thiolester hydrolase activity very long-chain fatty acid catabolic process acyl-CoA hydrolase activity carboxylic ester hydrolase activity uc011yor.1 uc011yor.2 uc011yor.3 uc011yor.4 
ENSMUST00000021652.5 Acot4 ENSMUST00000021652.5 acyl-CoA thioesterase 4 (from RefSeq NM_134247.3) ACOT4_MOUSE ENSMUST00000021652.1 ENSMUST00000021652.2 ENSMUST00000021652.3 ENSMUST00000021652.4 NM_134247 Pte1b Pte2b Q8BJQ1 Q8BL20 Q8BWN8 Q9QYR8 uc007oed.1 uc007oed.2 uc007oed.3 Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16141203, PubMed:16940157). In contrast to its human ortholog, functions essentially as a succinyl-CoA thioesterase with no activity with medium to long chain saturated acyl-CoAs and with a low activity toward glutaryl-CoA (PubMed:16141203, PubMed:16940157). Reaction=H2O + succinyl-CoA = CoA + H(+) + succinate; Xref=Rhea:RHEA:11516, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30031, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292; EC=3.1.2.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11517; Evidence=; Reaction=glutaryl-CoA + H2O = CoA + glutarate + H(+); Xref=Rhea:RHEA:40575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30921, ChEBI:CHEBI:57287, ChEBI:CHEBI:57378; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40576; Evidence=; Kinetic parameters: KM=13.3 uM for succinyl-CoA ; KM=37.1 uM for glutaryl-CoA ; Vmax=3.98 umol/min/mg enzyme with succinyl-CoA as substrate ; Vmax=1.14 umol/min/mg enzyme with glutaryl-CoA as substrate ; Lipid metabolism; fatty acid metabolism. Peroxisome Mainly expressed in liver and kidney. Weakly expressed in other tissues including intestine, adrenal gland and adipose tissues. In the liver, by peroxisome proliferator (Clofibrate) treatment, via the peroxisome proliferator-activated receptors (PPARs) or fasting for 24 hours. Belongs to the C/M/P thioester hydrolase family. very long-chain fatty acid metabolic process long-chain fatty acid metabolic process succinyl-CoA hydrolase activity peroxisome succinyl-CoA metabolic process lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process hydrolase activity thiolester hydrolase activity saturated monocarboxylic acid metabolic process unsaturated monocarboxylic acid metabolic process dicarboxylic acid metabolic process dicarboxylic acid catabolic process short-chain fatty acid metabolic process acyl-CoA hydrolase activity carboxylic ester hydrolase activity uc007oed.1 uc007oed.2 uc007oed.3 
ENSMUST00000021665.12 Vsx2 ENSMUST00000021665.12 visual system homeobox 2, transcript variant 2 (from RefSeq NM_007701.3) Chx10 ENSMUST00000021665.1 ENSMUST00000021665.10 ENSMUST00000021665.11 ENSMUST00000021665.2 ENSMUST00000021665.3 ENSMUST00000021665.4 ENSMUST00000021665.5 ENSMUST00000021665.6 ENSMUST00000021665.7 ENSMUST00000021665.8 ENSMUST00000021665.9 NM_007701 Q80WF9 Q80WF9_MOUSE Vsx2 uc007ofm.1 uc007ofm.2 uc007ofm.3 uc007ofm.4 This gene encodes a member of the Vsx (visual system homeobox) family which belongs to the larger PRD homeobox class. The encoded protein is required for eye organogenesis and controls retinal development. Disruption of this gene is associated with ocular retardation J (orJ), a mouse disease which causes microphthalmia, retinal degeneration and optic nerve aplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. Nucleus Belongs to the paired homeobox family. DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development sequence-specific DNA binding uc007ofm.1 uc007ofm.2 uc007ofm.3 uc007ofm.4 
ENSMUST00000021666.6 Abcd4 ENSMUST00000021666.6 ATP-binding cassette, sub-family D member 4, transcript variant 3 (from RefSeq NR_186732.1) ABCD4_MOUSE Abcd4 E9QKU3 ENSMUST00000021666.1 ENSMUST00000021666.2 ENSMUST00000021666.3 ENSMUST00000021666.4 ENSMUST00000021666.5 NR_186732 O89016 Pxmp1l uc007ofo.1 uc007ofo.2 uc007ofo.3 uc007ofo.4 Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner. Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane. Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane. Reaction=an R-cob(III)alamin(out) + ATP + H2O = ADP + an R- cob(III)alamin(in) + H(+) + phosphate; Xref=Rhea:RHEA:17873, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:140785, ChEBI:CHEBI:456216; EC=7.6.2.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17874; Evidence=; Homodimer or heterodimer. Interacts with LMBRD1; this interaction induces the translocation of ABCD4 from the ER to the lysosome membrane. Interacts with LMBRD1 and MMACHC; this interaction ensures the transport of cobalamin from the lysosome to the cytosol. Endoplasmic reticulum membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. Originally proposed to be a peroxisomal protein (By similarity). Recent studies have suggested its localization to the endoplasmic reticulum and within the lysosome (By similarity). nucleotide binding ATP binding endoplasmic reticulum membrane cobalamin metabolic process membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances transmembrane transport cellular response to leukemia inhibitory factor peroxisome uc007ofo.1 uc007ofo.2 uc007ofo.3 uc007ofo.4 
ENSMUST00000021667.7 Isca2 ENSMUST00000021667.7 iron-sulfur cluster assembly 2 (from RefSeq NM_028863.1) ENSMUST00000021667.1 ENSMUST00000021667.2 ENSMUST00000021667.3 ENSMUST00000021667.4 ENSMUST00000021667.5 ENSMUST00000021667.6 Hbld1 ISCA2_MOUSE NM_028863 Q9DCB8 uc007ofu.1 uc007ofu.2 uc007ofu.3 uc007ofu.4 Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly. Mitochondrion Belongs to the HesB/IscA family. Sequence=BAB22467.1; Type=Erroneous initiation; Evidence=; structural molecule activity iron ion binding mitochondrion iron-sulfur cluster assembly metal ion binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding 4 iron, 4 sulfur cluster binding protein maturation protein maturation by iron-sulfur cluster transfer uc007ofu.1 uc007ofu.2 uc007ofu.3 uc007ofu.4 
ENSMUST00000021668.10 Npc2 ENSMUST00000021668.10 NPC intracellular cholesterol transporter 2 (from RefSeq NM_023409.4) ENSMUST00000021668.1 ENSMUST00000021668.2 ENSMUST00000021668.3 ENSMUST00000021668.4 ENSMUST00000021668.5 ENSMUST00000021668.6 ENSMUST00000021668.7 ENSMUST00000021668.8 ENSMUST00000021668.9 NM_023409 NPC2_MOUSE Npc2 Q3UB23 Q9Z0J0 uc007oft.1 uc007oft.2 uc007oft.3 Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:12591949, PubMed:17018531, PubMed:21315718, PubMed:26296895). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (PubMed:21315718). Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747, ChEBI:CHEBI:16113; Evidence=; Interacts with NPC1 (via the second lumenal domain) in a cholestrol-dependent manner. Interacts with NUS1/NgBR, the interaction stabilizes NCP2 and regulates cholesterol trafficking. Interacts with DHDDS. Interacts with NEDD4L (via C2 domain). Interacts with NPC1L1. Secreted doplasmic reticulum Lysosome Note=Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes. Detected in liver and bile (PubMed:21315718). Detected in epididymis (at protein level). Detected in caput epididymis, corpus epididymis, cauda epididymis and ovary (PubMed:10863096). Binds cholesterol in a hydrophobic pocket; there are no hydrogen bonds between the sterol and the protein. N-glycosylated. Belongs to the NPC2 family. extracellular region extracellular space lysosome endoplasmic reticulum lipid metabolic process lipid transport steroid metabolic process cholesterol metabolic process cholesterol binding sterol transport enzyme binding cholesterol transport intracellular sterol transport intracellular cholesterol transport sterol binding cholesterol efflux cholesterol homeostasis uc007oft.1 uc007oft.2 uc007oft.3 
ENSMUST00000021669.15 Fcf1 ENSMUST00000021669.15 FCF1 rRNA processing protein (from RefSeq NM_028632.2) ENSMUST00000021669.1 ENSMUST00000021669.10 ENSMUST00000021669.11 ENSMUST00000021669.12 ENSMUST00000021669.13 ENSMUST00000021669.14 ENSMUST00000021669.2 ENSMUST00000021669.3 ENSMUST00000021669.4 ENSMUST00000021669.5 ENSMUST00000021669.6 ENSMUST00000021669.7 ENSMUST00000021669.8 ENSMUST00000021669.9 FCF1_MOUSE NM_028632 Q505C6 Q8K261 Q9CTH6 uc007ogc.1 uc007ogc.2 uc007ogc.3 uc007ogc.4 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus Belongs to the UTP23/FCF1 family. FCF1 subfamily. Sequence=AAH33045.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleus nucleolus rRNA processing small-subunit processome ribosome biogenesis uc007ogc.1 uc007ogc.2 uc007ogc.3 uc007ogc.4 
ENSMUST00000021674.7 Fos ENSMUST00000021674.7 FBJ osteosarcoma oncogene (from RefSeq NM_010234.3) ENSMUST00000021674.1 ENSMUST00000021674.2 ENSMUST00000021674.3 ENSMUST00000021674.4 ENSMUST00000021674.5 ENSMUST00000021674.6 FOS_MOUSE NM_010234 P01101 uc007oha.1 uc007oha.2 uc007oha.3 uc007oha.4 uc007oha.5 Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr- dephosphorylation and association with the endoplasmic reticulum. Heterodimer; with JUN (PubMed:29272704). Component of the SMAD3/SMAD4/JUN/FOS complex required for synergistic TGF-beta-mediated transcription at the AP1 promoter site (By similarity). Interacts with SMAD3; the interaction is weak even on TGF-beta activation (By similarity). Interacts with MAFB (By similarity). Interacts with TSC22D3 (via N-terminus); this interaction inhibits the binding of active AP1 to its target DNA (PubMed:11397794). Interacts with CDS1 and PI4K2A, but not with CDIPT, nor PI4K2B (PubMed:22105363). Interacts (via bZIP domain and leucine-zipper region) with the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF) subunits SMARCB1, SMARCC2 and SMARCD1 (PubMed:29272704). Interacts (via bZIP domain and leucine-zipper region) with ARID1A (PubMed:29272704). P01101; O08537: Esr2; NbExp=2; IntAct=EBI-4288185, EBI-2526214; P01101; P54841: Mafb; NbExp=4; IntAct=EBI-4288185, EBI-16093217; P01101; P14404: Mecom; NbExp=2; IntAct=EBI-4288185, EBI-1994523; Nucleus Endoplasmic reticulum Cytoplasm, cytosol Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30 (By similarity). Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation (By similarity). Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232 (By similarity). In quiescent cells, the small amount of FOS present is phosphorylated at Tyr-10 and Tyr-30 by SRC. This Tyr-phosphorylated form is cytosolic. In growing cells, dephosphorylated by PTPN2. Dephosphorylation leads to the association with endoplasmic reticulum membranes and activation of phospholipid synthesis. Belongs to the bZIP family. Fos subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding conditioned taste aversion DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm endoplasmic reticulum cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway nervous system development female pregnancy aging transcription factor binding response to cold response to light stimulus response to mechanical stimulus response to gravity response to toxic substance regulation of gene expression response to organic cyclic compound membrane sleep cellular response to extracellular stimulus response to lipopolysaccharide response to progesterone cellular response to hormone stimulus protein-DNA complex response to cytokine cellular response to reactive oxygen species response to immobilization stress skeletal muscle cell differentiation transcription factor AP-1 complex response to muscle stretch response to drug neuron projection sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of osteoclast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity response to corticosterone response to cAMP SMAD protein signal transduction R-SMAD binding cellular response to cadmium ion cellular response to calcium ion positive regulation of neuron death positive regulation of pri-miRNA transcription from RNA polymerase II promoter uc007oha.1 uc007oha.2 uc007oha.3 uc007oha.4 uc007oha.5 
ENSMUST00000021676.12 Erg28 ENSMUST00000021676.12 ergosterol biosynthesis 28, transcript variant 3 (from RefSeq NR_153807.1) ENSMUST00000021676.1 ENSMUST00000021676.10 ENSMUST00000021676.11 ENSMUST00000021676.2 ENSMUST00000021676.3 ENSMUST00000021676.4 ENSMUST00000021676.5 ENSMUST00000021676.6 ENSMUST00000021676.7 ENSMUST00000021676.8 ENSMUST00000021676.9 ERG28_MOUSE Erg28 NR_153807 Orf11 Q3U8G1 Q9ERY9 uc007ohf.1 uc007ohf.2 uc007ohf.3 Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the ERG28 family. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process ergosterol biosynthetic process steroid metabolic process membrane integral component of membrane sterol biosynthetic process transport vesicle protein binding, bridging uc007ohf.1 uc007ohf.2 uc007ohf.3 
ENSMUST00000021681.4 Vash1 ENSMUST00000021681.4 vasohibin 1 (from RefSeq NM_177354.4) E9QKT9 ENSMUST00000021681.1 ENSMUST00000021681.2 ENSMUST00000021681.3 NM_177354 Q8C1W1 Q8C394 VASH1_MOUSE Vash Vash1 uc007ohx.1 uc007ohx.2 uc007ohx.3 uc007ohx.4 Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146868). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:19204325). This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (By similarity). Reaction=C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl- [tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl- [tubulin] + L-tyrosine; Xref=Rhea:RHEA:57444, Rhea:RHEA-COMP:16434, Rhea:RHEA-COMP:16435, ChEBI:CHEBI:15377, ChEBI:CHEBI:58315, ChEBI:CHEBI:149554, ChEBI:CHEBI:149555; EC=3.4.17.17; Evidence=; Interacts with SVBP; interaction enhances VASH1 tyrosine carboxypeptidase activity. Cytoplasm Secreted Note=Mainly localizes in the cytoplasm. Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion. Expressed at low level in proliferating endothelial cells at the sprouting front but highly expressed in nonproliferating endothelial cells in the termination zone. Ubiquitinated in vitro. Belongs to the transglutaminase-like superfamily. Vasohibin family. Sequence=BAC41121.1; Type=Frameshift; Evidence=; angiogenesis negative regulation of endothelial cell proliferation actin binding carboxypeptidase activity metallocarboxypeptidase activity protein binding extracellular region extracellular space cytoplasm endoplasmic reticulum proteolysis cell cycle cell cycle arrest peptidase activity response to wounding negative regulation of endothelial cell migration positive regulation of gene expression negative regulation of angiogenesis hydrolase activity negative regulation of blood vessel endothelial cell migration apical part of cell regulation of angiogenesis placenta blood vessel development labyrinthine layer blood vessel development negative regulation of lymphangiogenesis regulation of cellular senescence uc007ohx.1 uc007ohx.2 uc007ohx.3 uc007ohx.4 
ENSMUST00000021682.9 Angel1 ENSMUST00000021682.9 angel homolog 1 (from RefSeq NM_144524.2) ANGE1_MOUSE Angel1 ENSMUST00000021682.1 ENSMUST00000021682.2 ENSMUST00000021682.3 ENSMUST00000021682.4 ENSMUST00000021682.5 ENSMUST00000021682.6 ENSMUST00000021682.7 ENSMUST00000021682.8 Kiaa0759 NM_144524 Q5DU16 Q8VCU0 uc011ypj.1 uc011ypj.2 Belongs to the CCR4/nocturin family. 3'-5'-exoribonuclease activity nucleus endoplasmic reticulum cis-Golgi network cytosol eukaryotic initiation factor 4E binding protein domain specific binding perinuclear region of cytoplasm RNA phosphodiester bond hydrolysis, exonucleolytic uc011ypj.1 uc011ypj.2 
ENSMUST00000021684.6 Cyp46a1 ENSMUST00000021684.6 cytochrome P450, family 46, subfamily a, polypeptide 1, transcript variant 2 (from RefSeq NR_176848.1) CP46A_MOUSE Cyp46 Cyp46a1 ENSMUST00000021684.1 ENSMUST00000021684.2 ENSMUST00000021684.3 ENSMUST00000021684.4 ENSMUST00000021684.5 NR_176848 Q9WVK8 uc007ozo.1 uc007ozo.2 P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:16505352, PubMed:28190002). By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning (PubMed:16505352). Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis (By similarity). Acts as an epoxidase converting cholesta- 5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain (By similarity). May also catalyze the oxidative metabolism of xenobiotics, such as clotrimazole (By similarity). Reaction=cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:22716, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:34310, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.25; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22717; Evidence=; Reaction=cholestanol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53808, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:86570, ChEBI:CHEBI:137687; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53809; Evidence=; Reaction=7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53244, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17759, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:137061; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53245; Evidence=; Reaction=7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53240, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17759, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:137057; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53241; Evidence=; Reaction=desmosterol + O2 + reduced [NADPH--hemoprotein reductase] = (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:53236, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17737, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:137053; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53237; Evidence=; Reaction=desmosterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53232, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17737, ChEBI:CHEBI:41633, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53233; Evidence=; Reaction=4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46392, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:85778, ChEBI:CHEBI:86087; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46393; Evidence=; Reaction=(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46388, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:34310, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:86165; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46389; Evidence=; Reaction=(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46384, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:34310, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:86074; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46385; Evidence=; Reaction=7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46380, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17500, ChEBI:CHEBI:37640, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46381; Evidence=; Reaction=O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:46308, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17026, ChEBI:CHEBI:17252, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46309; Evidence=; Reaction=O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46304, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17347, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:83027; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46305; Evidence=; Reaction=O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46300, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17347, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:86013; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46301; Evidence=; Reaction=O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46296, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17347, ChEBI:CHEBI:34477, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46297; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Steroid metabolism; cholesterol degradation. Lipid metabolism; C21-steroid hormone metabolism. Endoplasmic reticulum membrane ; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Postsynapse Presynapse Cell projection, dendrite Expressed in high level in the pyramidal cells of the hippocampus, Purkinje cells of the cerebellum, and neuronal cell bodies in layers II/III, V, and VI of the cortex. Expressed in hippocampal and cerebellar interneurons, in retinal ganglion cells, and in a subset of retinal cells localized to the inner nuclear layer (at protein level). Mutant mice are deficient in spatial, associative and motor learning. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process cholesterol catabolic process xenobiotic metabolic process steroid metabolic process cholesterol metabolic process C21-steroid hormone metabolic process steroid hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding cell junction dendrite organelle membrane cholesterol 24-hydroxylase activity progesterone metabolic process cell projection intracellular membrane-bounded organelle synapse metal ion binding oxidation-reduction process presynapse postsynapse regulation of long-term synaptic potentiation uc007ozo.1 uc007ozo.2 
ENSMUST00000021685.8 Hhipl1 ENSMUST00000021685.8 hedgehog interacting protein-like 1 (from RefSeq NM_001044380.1) ENSMUST00000021685.1 ENSMUST00000021685.2 ENSMUST00000021685.3 ENSMUST00000021685.4 ENSMUST00000021685.5 ENSMUST00000021685.6 ENSMUST00000021685.7 HIPL1_MOUSE Hhip2 Kiaa1822 NM_001044380 Q14CI0 Q14DK5 Q3UGD3 Q3UU97 Q6ZPH6 uc007ozn.1 uc007ozn.2 uc007ozn.3 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14DK5-1; Sequence=Displayed; Name=2; IsoId=Q14DK5-2; Sequence=VSP_030457, VSP_030458; Belongs to the HHIP family. catalytic activity scavenger receptor activity extracellular region endocytosis biological_process membrane uc007ozn.1 uc007ozn.2 uc007ozn.3 
ENSMUST00000021691.6 Degs2 ENSMUST00000021691.6 delta 4-desaturase, sphingolipid 2, transcript variant 1 (from RefSeq NM_027299.5) DEGS2_MOUSE Degs2 ENSMUST00000021691.1 ENSMUST00000021691.2 ENSMUST00000021691.3 ENSMUST00000021691.4 ENSMUST00000021691.5 NM_027299 Q3TR85 Q78JJ1 Q8R2F2 uc007pab.1 uc007pab.2 uc007pab.3 uc007pab.4 Bifunctional enzyme which acts both as a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. Reaction=a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O; Xref=Rhea:RHEA:55808, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:139048, ChEBI:CHEBI:139051; EC=1.14.18.5; Evidence=; Reaction=an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:46544, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:31488, ChEBI:CHEBI:52639; EC=1.14.19.17; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46545; Evidence=; Reaction=an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O; Xref=Rhea:RHEA:46364, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:31488, ChEBI:CHEBI:31998; EC=1.14.18.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46365; Evidence=; Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine; Xref=Rhea:RHEA:43116, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:82841, ChEBI:CHEBI:82842; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43117; Evidence=; pH dependence: Optimum pH is 7.0-8.0. ; Membrane lipid metabolism; sphingolipid biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8R2F2-1; Sequence=Displayed; Name=2 ; IsoId=Q8R2F2-2; Sequence=VSP_052629; Highly expressed in intestinal crypt cells and adjacent epithelial cells (at protein level). Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. sphingosine hydroxylase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process sphinganine metabolic process membrane integral component of membrane oxidoreductase activity sphingolipid biosynthetic process sphingolipid delta-4 desaturase activity ceramide biosynthetic process oxidation-reduction process uc007pab.1 uc007pab.2 uc007pab.3 uc007pab.4 
ENSMUST00000021692.9 Yy1 ENSMUST00000021692.9 YY1 transcription factor (from RefSeq NM_009537.4) ENSMUST00000021692.1 ENSMUST00000021692.2 ENSMUST00000021692.3 ENSMUST00000021692.4 ENSMUST00000021692.5 ENSMUST00000021692.6 ENSMUST00000021692.7 ENSMUST00000021692.8 NM_009537 Q00899 TYY1_MOUSE Ucrbp uc007pac.1 uc007pac.2 uc007pac.3 Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. Binds to the upstream conserved region (UCR) (5'-CGCCATTTT- 3') of Moloney murine leukemia virus (MuLV). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Involved in spermatogenesis and may play a role in meiotic DNA double- strand break repair. Plays a role in regulating enhancer activation (By similarity). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. Interacts with YAF2 through the region encompassing the first and second zinc fingers. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Interacts with EED and EZH2; the interactions are indicative for an association with the PRC2/EED-EZH2 complex (By similarity). Found in a complex with SMAD1 and SMAD4 (PubMed:15329343). Interacts with SFMBT2 (PubMed:18024232). Found in a complex with YY1, SIN3A and HDAC1 (PubMed:21454521). Q00899; Q9JLN9: Mtor; NbExp=4; IntAct=EBI-6921536, EBI-1571628; Q00899; O70343: Ppargc1a; NbExp=5; IntAct=EBI-6921536, EBI-1371053; Q00899; Q8K4Q0: Rptor; NbExp=3; IntAct=EBI-6921536, EBI-4567273; Q00899; Q8CG47: Smc4; NbExp=2; IntAct=EBI-6921536, EBI-6921575; Q00899; P48432: Sox2; NbExp=2; IntAct=EBI-6921536, EBI-2313612; Nucleus Nucleus matrix Cytoplasm Note=Associated with the nuclear matrix. In testis, localized to heterochromatin of spermatocytes. Expressed in ovary and, at lower levels, in testis. At 7.5 dpc, highly expressed in the ectoplacental cone and, at lower levels, in the embryonic and extraembryonic ectoderm. At 14.5 dpc, highly expressed in placenta and yolk sac, and, at lower levels, in brain and heart. Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites. Ubiquitinated. Phosphorylation at Ser-120 by CK2 prevents proteolytic cleavage by caspase-7 (CASP7) during apoptosis. Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis. Phosphorylation at Ser-120 protects against proteolytic cleavage. Spermatocytes have a significant decrease in the global level of the heterochromatin markers and increase in the chromosomal double-strand break (DSB) signals at the leptotene/zygotene stages. Belongs to the YY transcription factor family. negative regulation of transcription from RNA polymerase II promoter four-way junction DNA binding double-strand break repair via homologous recombination nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding RNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm DNA repair DNA recombination regulation of transcription, DNA-templated RNA localization cellular response to DNA damage stimulus spermatogenesis anterior/posterior pattern specification response to UV-C positive regulation of gene expression negative regulation of gene expression nuclear matrix cell differentiation Ino80 complex PcG protein complex negative regulation of interferon-beta production cellular response to UV response to prostaglandin F sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter SMAD binding metal ion binding camera-type eye morphogenesis chromosome organization negative regulation of cell growth involved in cardiac muscle cell development cellular response to interleukin-1 negative regulation of pri-miRNA transcription from RNA polymerase II promoter uc007pac.1 uc007pac.2 uc007pac.3 
ENSMUST00000021693.4 Slc25a29 ENSMUST00000021693.4 solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29 (from RefSeq NM_181328.3) ENSMUST00000021693.1 ENSMUST00000021693.2 ENSMUST00000021693.3 NM_181328 Ornt3 Q8BL03 Q922X4 S2529_MOUSE uc007pad.1 uc007pad.2 uc007pad.3 Mitochondrial transporter of arginine, lysine, homoarginine, methylarginine (By similarity). Transports with a much lesser extent, ornithine and histidine (PubMed:19287344). Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms. Plays a physiolocical role in the import of basic amino acids into mitochondria for mitochondrial protein synthesis and amino acid degradation (By similarity). Reaction=L-arginine(in) + L-lysine(out) = L-arginine(out) + L- lysine(in); Xref=Rhea:RHEA:70827, ChEBI:CHEBI:32551, ChEBI:CHEBI:32682; Evidence=; Reaction=L-arginine(in) + L-histidine(out) = L-arginine(out) + L- histidine(in); Xref=Rhea:RHEA:71063, ChEBI:CHEBI:32682, ChEBI:CHEBI:57595; Evidence=; Reaction=L-arginine(out) + L-ornithine(in) = L-arginine(in) + L- ornithine(out); Xref=Rhea:RHEA:34991, ChEBI:CHEBI:32682, ChEBI:CHEBI:46911; Evidence=; Reaction=L-arginine(out) + L-homoarginine(in) = L-arginine(in) + L- homoarginine(out); Xref=Rhea:RHEA:72799, ChEBI:CHEBI:32682, ChEBI:CHEBI:143006; Evidence=; Reaction=L-arginine(out) + N(omega)-methyl-L-arginine(in) = L- arginine(in) + N(omega)-methyl-L-arginine(out); Xref=Rhea:RHEA:72803, ChEBI:CHEBI:32682, ChEBI:CHEBI:114953; Evidence=; Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143, ChEBI:CHEBI:32682; Evidence=; Reaction=L-lysine(in) = L-lysine(out); Xref=Rhea:RHEA:70935, ChEBI:CHEBI:32551; Evidence=; Reaction=L-ornithine(in) = L-ornithine(out); Xref=Rhea:RHEA:71199, ChEBI:CHEBI:46911; Evidence=; Reaction=L-histidine(out) = L-histidine(in); Xref=Rhea:RHEA:72807, ChEBI:CHEBI:57595; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Widely expressed, with highest levels in the brain, including cortex, cerebellum, hippocampus and hypothalamus, and moderate levels in liver, kidney, heart and testis. By partial hepactectomy and fasting. Belongs to the mitochondrial carrier (TC 2.A.29) family. Was initially proposed to transport palmitoylcarnitine, based on complementation experiments in yeast mutants lacking CRC1 and CIT2 and release of radiolabeled carnitine from mitochondria incubated with radiolabeled palmitoylcarnithine (PubMed:12882971). Later experiments done primarily with human indicate the protein functions instead as transporter of basic amino acids (By similarity). high-affinity arginine transmembrane transporter activity high-affinity lysine transmembrane transporter activity mitochondrion mitochondrial inner membrane acyl carnitine transport amino acid transport basic amino acid transmembrane transporter activity acyl carnitine transmembrane transporter activity ornithine transport membrane integral component of membrane transmembrane transporter activity transmembrane transport L-histidine transmembrane transport acyl carnitine transmembrane transport L-arginine transmembrane transport L-lysine transmembrane transport mitochondrial L-ornithine transmembrane transport carnitine transport uc007pad.1 uc007pad.2 uc007pad.3 
ENSMUST00000021706.11 Traf3 ENSMUST00000021706.11 TNF receptor-associated factor 3, transcript variant 1 (from RefSeq NM_011632.3) B2RPW3 Cap-1 Craf1 ENSMUST00000021706.1 ENSMUST00000021706.10 ENSMUST00000021706.2 ENSMUST00000021706.3 ENSMUST00000021706.4 ENSMUST00000021706.5 ENSMUST00000021706.6 ENSMUST00000021706.7 ENSMUST00000021706.8 ENSMUST00000021706.9 NM_011632 Q60803 Q62380 TRAF3_MOUSE Traf3 Trafamn uc007pcl.1 uc007pcl.2 uc007pcl.3 uc007pcl.4 Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:17015635). In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:19898473, PubMed:23871208, PubMed:26305951, PubMed:23150880). Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines (PubMed:16306937). Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance. Acts also as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development (PubMed:17723217). Required for normal antibody isotype switching from IgM to IgG (PubMed:19228877). Plays a role T-cell dependent immune responses (PubMed:8934568). Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Homotrimer. Heterotrimer with TRAF2 and TRAF5. Interacts with LTBR/TNFRSF3, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF13C TNFRSF17/BCMA, TLR4 and EDAR. Interacts with MAP3K5, MAP3K14, TRAIP/TRIP, TDP2/TTRAP, TANK/ITRAF and TRAF3IP1. Interaction with TNFRSF5/CD40 is modulated by TANK/ITRAF, which competes for the same binding site. Interacts with TICAM1. Interacts with TRAFD1. Interacts with OTUB1, OTUB2 and OTUD5. Interacts with RNF216, OPTN and TBK1 (By similarity). Identified in a complex with TRAF2, MAP3K14 and BIRC3. Upon exposure to bacterial lipopolysaccharide (LPS), recruited to a transient complex containing TLR4, TRAF3, TRAF6, IKBKG, MAP3K7, MYD88, TICAM1, BIRC2, BIRC3 and UBE2N. Interacts (via RING-type zinc finger domain) with SRC. Interacts with CARD14 (By similarity). Interacts (via MATH domain) with PTPN22; the interaction promotes TRAF3 polyubiquitination (PubMed:23871208). Interacts with MAVS (PubMed:23150880). Directly interacts with DDX3X; this interaction stimulates TRAF3 'Lys-63' ubiquitination (By similarity). Interacts with IRF3 (By similarity). Interacts with IKBKE in the course of viral infection (By similarity). Interacts with TRIM35 (By similarity). Interacts with GAPDH; promoting TRAF3 ubiquitination (By similarity). Interacts with PPP3CA and PPP3CB (PubMed:26029823). Interacts with RALGDS (By similarity). Interacts with FBXO11 (By similarity). Q60803; Q8VCF0: Mavs; NbExp=4; IntAct=EBI-520135, EBI-3862816; Q60803; P22366: Myd88; NbExp=5; IntAct=EBI-520135, EBI-525108; Q60803; Q80UF7: Ticam1; NbExp=2; IntAct=EBI-520135, EBI-3649271; Q60803; O35305: Tnfrsf11a; NbExp=3; IntAct=EBI-520135, EBI-647362; Q60803; P39429: Traf2; NbExp=2; IntAct=EBI-520135, EBI-520016; Q60803; P62991: Ubc; NbExp=2; IntAct=EBI-520135, EBI-413074; Q60803; Q9Y2R2: PTPN22; Xeno; NbExp=5; IntAct=EBI-520135, EBI-1211241; Q60803; Q9UHD2: TBK1; Xeno; NbExp=2; IntAct=EBI-520135, EBI-356402; Cytoplasm Endosome Mitochondrion Note=Undergoes endocytosis together with TLR4 upon LPS signaling (PubMed:19898473). Co-localized to mitochondria with TRIM35 (By similarity). Detected in bone marrow macrophages and spleen B- cells (at protein level). In adult, highest in brain. Also found in kidney, heart, thymus, spleen, lung, muscle, testis and ovary. Not found in liver. In the embryo, expressed from 6.5 dpc with highest levels found between 11.5 dpc and 13.5 dpc. At late stages of gestation, from 14.5 dpc, only low levels are detected. The MATH/TRAF domain binds to receptor cytoplasmic domains. The Ring-type zinc finger domain is required for its function in down-regulation of NFKB2 proteolytic processing. Undergoes 'Lys-48'-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by TNFSF13B, TLR4 or through CD40 (PubMed:19898473). 'Lys-48'-linked polyubiquitinated form is deubiquitinated by OTUD7B, preventing TRAF3 proteolysis and over- activation of non-canonical NF-kappa-B (PubMed:23334419). Undergoes 'Lys-63'-linked ubiquitination during early stages of virus infection, and 'Lys-48'-linked ubiquitination during later stages. Undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to TLR3 and TLR4 signaling. 'Lys-63'-linked ubiquitination can be mediated by TRIM35. Deubiquitinated by OTUB1, OTUB2 and OTUD5. Undergoes 'Lys-63'- linked deubiquitination by MYSM1 to terminate the pattern-recognition receptors/PRRs pathways (PubMed:26474655). Ubiquitinated at Lys-328 by the SCF(FBXL2) complex, leading to its degradation by the proteasome (PubMed:23542741). Undergoes 'Lys-48'-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by TNFSF13B, TLR4 or through CD40. 'Lys-48'-linked polyubiquitinated form is deubiquitinated by OTUD7B, preventing TRAF3 proteolysis and over-activation of non- canonical NF-kappa-B. Undergoes 'Lys-63'-linked ubiquitination during early stages of virus infection, and 'Lys-48'-linked ubiquitination during later stages. Undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to TLR3 and TLR4 signaling. 'Lys-63'-linked ubiquitination can be mediated by TRIM35. Deubiquitinated by OTUB1, OTUB2 and OTUD5. Undergoes 'Lys-63'-linked deubiquitination by MYSM1 to terminate the pattern-recognition receptors/PRRs pathways (By similarity). Undergoes also 'Lys-29'-linked ubiquitination on Cys-55 and Cys-123 by NEDD4L; leading to increased 'Lys-48'- and 'Lys-63'- linked ubiquitination as well as increased binding to TBK1. TLR4 signals emanating from bacteria containing vesicles trigger 'Lys-33'- linked polyubiquitination that promotes the assembly of the exocyst complex thereby connecting innate immune signaling to the cellular trafficking apparatus (By similarity). Deubiquitinated by USP25 during viral infection, leading to TRAF3 stabilization and type I interferon production (PubMed:26305951). 'Lys-63'-linked ubiquitination by FBXO11 in a NEDD8-dependent manner promotes the amplification of IFN-I signaling (By similarity). Newborns appear normal, but do not thrive. Their blood glucose levels and leukocyte levels decrease steadily, the spleen size is dramatically reduced, and they become progressively runted. They die about ten days after birth. Mice exhibit abnormally high MAP3K14 protein levels and constitutive proteolytic processing of NFKB2/p100, leading to constitutive activation of NF-kappa-B. Belongs to the TNF receptor-associated factor family. A subfamily. regulation of cytokine production toll-like receptor signaling pathway immune system process tumor necrosis factor receptor binding protein binding cytoplasm endosome apoptotic process signal transduction Toll signaling pathway zinc ion binding cytoplasmic side of plasma membrane transferase activity protein kinase binding protein phosphatase binding regulation of proteolysis ubiquitin protein ligase binding thioesterase binding negative regulation of NF-kappaB transcription factor activity regulation of interferon-beta production macromolecular complex tumor necrosis factor-mediated signaling pathway CD40 receptor complex regulation of apoptotic process innate immune response metal ion binding regulation of defense response to virus uc007pcl.1 uc007pcl.2 uc007pcl.3 uc007pcl.4 
ENSMUST00000021707.8 Amn ENSMUST00000021707.8 amnionless (from RefSeq NM_033603.3) AMNLS_MOUSE ENSMUST00000021707.1 ENSMUST00000021707.2 ENSMUST00000021707.3 ENSMUST00000021707.4 ENSMUST00000021707.5 ENSMUST00000021707.6 ENSMUST00000021707.7 NM_033603 Q5I0U1 Q99JB7 Q99MP9 uc007pcp.1 uc007pcp.2 uc007pcp.3 uc007pcp.4 This gene encodes a type I transmembrane protein. The encoded protein is an essential component of the cubulin receptor complex which is thought to play a role in coordinating growth and patterning of the embryo. This protein is thought to modulate a bone morphogenetic protein (BMP) signaling pathway. A homoygous mutation in the mouse gene results in the lack of an amnion in embryos. Mutations in the human gene are associated with Megaloblastic Anemia-1. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF320619.1, AK017204.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Membrane-bound component of the endocytic receptor formed by AMN and CUBN. Required for normal CUBN glycosylation and trafficking to the cell surface (PubMed:15342463). The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12 (By similarity). Required for normal CUBN-mediated protein transport in the kidney (PubMed:15342463). Interacts (via extracellular region) with CUBN/cubilin (PubMed:15342463). This gives rise to a huge complex containing one AMN chain and three CUBN chains (By similarity). Apical cell membrane ; Single-pass type I membrane protein Cell membrane ; Single-pass type I membrane protein Endosome membrane Membrane, coated pit Expressed in polarized epithelial cells which are specialized in resorption or transport, specifically kidney proximal tubules and intestinal epithelium. Detected in primitive endoderm at 4.5 dpc, and on the apical surface of the visceral endoderm from 5.5 dpc to 8.5 dpc. Expressed in mesonephric tubules at 11.5-12.5 dpc and in the metanephric kidney beginning at 14.5 dpc. Expressed in the intestine from 16.5 dpc. The complex formed by AMN and CUBN is composed of a 400 Angstrom long stem and a globular crown region. The stem region is probably formed by AMN and the CUBN N-terminal region, including the EGF-like domains. The crown is probably formed by the CUBN CUB domains. N-glycosylated. A soluble form arises by proteolytic removal of the membrane anchor. Full embryonic lethality at about 10.5 dpc with failure of primitive middle streak assembly and absence of trunk mesoderm formation. The role of Amn in embryonic development seems to be species specific. In mice, null mutations lead to embryonic lethality. Human mutations give rise to much milder symptoms. receptor binding extracellular space endosome plasma membrane clathrin-coated pit receptor-mediated endocytosis multicellular organism development excretion protein localization endosome membrane protein transport cobalamin transport membrane integral component of membrane apical plasma membrane endocytic vesicle brush border membrane macromolecular complex Golgi to plasma membrane protein transport apical part of cell uc007pcp.1 uc007pcp.2 uc007pcp.3 uc007pcp.4 
ENSMUST00000021714.9 Zfyve21 ENSMUST00000021714.9 zinc finger, FYVE domain containing 21, transcript variant 1 (from RefSeq NM_026752.4) A3KML1 ENSMUST00000021714.1 ENSMUST00000021714.2 ENSMUST00000021714.3 ENSMUST00000021714.4 ENSMUST00000021714.5 ENSMUST00000021714.6 ENSMUST00000021714.7 ENSMUST00000021714.8 NM_026752 Q3TBQ9 Q8VCM3 Q9D1E2 ZFY21_MOUSE uc007pea.1 uc007pea.2 uc007pea.3 uc007pea.4 Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta- 1/ITGB1 cell surface expression (By similarity). Interacts with PTK2/FAK1. Cell junction, focal adhesion. Cytoplasmic vesicle Endosome Widely expressed. The FYVE-type zinc finger mediates interaction with PTK2/FAK1, and also interaction with PI(3)P and association with endosomes. The C-terminal region exhibits a structure similar to canonical PH domains, but lacks a positively charged interface to bind phosphatidylinositol phosphate. Sequence=AAH19521.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI32249.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI32251.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB22923.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component endosome focal adhesion biological_process cell junction cytoplasmic vesicle metal ion binding uc007pea.1 uc007pea.2 uc007pea.3 uc007pea.4 
ENSMUST00000021715.6 Xrcc3 ENSMUST00000021715.6 X-ray repair complementing defective repair in Chinese hamster cells 3 (from RefSeq NM_028875.4) ENSMUST00000021715.1 ENSMUST00000021715.2 ENSMUST00000021715.3 ENSMUST00000021715.4 ENSMUST00000021715.5 NM_028875 Q9CXE6 XRCC3_MOUSE uc007pdz.1 uc007pdz.2 uc007pdz.3 uc007pdz.4 This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. Allelic variants in the human gene are associated with susceptibility to breast cancer and cutaneous malignant melanoma. [provided by RefSeq, Sep 2015]. ##Evidence-Data-START## Transcript exon combination :: AK014491.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C (By similarity). Interacts with RAD51C and RAD51. Part of the CX3 complex consisting of RAD51C and XRCC3; the complex has a ring-like structure arranged into a flat disc around a central channel; CX3 can interact with RAD51 in vitro. Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3 (By similarity). Nucleus Cytoplasm Cytoplasm, perinuclear region Mitochondrion matrix Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair. Belongs to the RecA family. RAD51 subfamily. nucleotide binding four-way junction DNA binding telomere maintenance via recombination double-strand break repair via homologous recombination DNA binding ATP binding nucleus nucleoplasm replication fork cytoplasm mitochondrion mitochondrial matrix cytosol DNA repair DNA recombination cellular response to DNA damage stimulus DNA-dependent ATPase activity crossover junction endodeoxyribonuclease activity response to organic substance regulation of centrosome duplication Rad51C-XRCC3 complex interstrand cross-link repair double-strand break repair via synthesis-dependent strand annealing perinuclear region of cytoplasm resolution of mitotic recombination intermediates positive regulation of mitotic cell cycle spindle assembly checkpoint t-circle formation uc007pdz.1 uc007pdz.2 uc007pdz.3 uc007pdz.4 
ENSMUST00000021719.7 Atp5mj ENSMUST00000021719.7 ATP synthase membrane subunit j, transcript variant 1 (from RefSeq NM_027360.3) ATP68_MOUSE Atp5mpl ENSMUST00000021719.1 ENSMUST00000021719.2 ENSMUST00000021719.3 ENSMUST00000021719.4 ENSMUST00000021719.5 ENSMUST00000021719.6 Mp68 NM_027360 P56379 uc007pef.1 uc007pef.2 uc007pef.3 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Minor subunit required to maintain the ATP synthase population in the mitochondria. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL. Mitochondrion membrane ; Single-pass membrane protein Belongs to the small mitochondrial proteolipid family. molecular_function mitochondrion mitochondrial proton-transporting ATP synthase complex biological_process membrane integral component of membrane mitochondrial membrane uc007pef.1 uc007pef.2 uc007pef.3 
ENSMUST00000021726.8 Adss1 ENSMUST00000021726.8 adenylosuccinate synthase 1 (from RefSeq NM_007421.2) ADSS1 ADSSL1 Adss1 Adssl1 ENSMUST00000021726.1 ENSMUST00000021726.2 ENSMUST00000021726.3 ENSMUST00000021726.4 ENSMUST00000021726.5 ENSMUST00000021726.6 ENSMUST00000021726.7 NM_007421 Q3UBP0 Q3UBP0_MOUSE uc007peu.1 uc007peu.2 uc007peu.3 uc007peu.4 Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Reaction=GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2- dicarboxyethyl)-AMP + phosphate; Xref=Rhea:RHEA:15753, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:57567, ChEBI:CHEBI:58053, ChEBI:CHEBI:58189; EC=6.3.4.4; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Homodimer. Cytoplasm Belongs to the adenylosuccinate synthetase family. nucleotide binding magnesium ion binding GTPase activity adenylosuccinate synthase activity GTP binding cytoplasm purine nucleotide biosynthetic process AMP biosynthetic process aspartate metabolic process glutamine metabolic process purine ribonucleoside monophosphate biosynthetic process response to muscle activity ligase activity cellular response to drug response to starvation protein homodimerization activity 'de novo' AMP biosynthetic process IMP metabolic process metal ion binding actin filament binding cellular response to electrical stimulus uc007peu.1 uc007peu.2 uc007peu.3 uc007peu.4 
ENSMUST00000021728.12 Siva1 ENSMUST00000021728.12 SIVA1, apoptosis-inducing factor, transcript variant 1 (from RefSeq NM_013929.2) ENSMUST00000021728.1 ENSMUST00000021728.10 ENSMUST00000021728.11 ENSMUST00000021728.2 ENSMUST00000021728.3 ENSMUST00000021728.4 ENSMUST00000021728.5 ENSMUST00000021728.6 ENSMUST00000021728.7 ENSMUST00000021728.8 ENSMUST00000021728.9 NM_013929 O54926 Q3U6J2 Q921I8 Q9CWL1 Q9R1Q0 Q9R1Q1 SIVA_MOUSE Siva uc007pev.1 uc007pev.2 uc007pev.3 uc007pev.4 Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Isoform 1 binds 3 zinc ions. Isoform 2 binds 2 zinc ions. ; Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX. Cytoplasm. Nucleus Note=In the nucleus, accumulates in dot-like structures. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Siva-1; IsoId=O54926-1; Sequence=Displayed; Name=2; Synonyms=Siva-2; IsoId=O54926-2; Sequence=VSP_007526; Highly expressed in testis, heart, liver, lung, and muscle, and less in kidney, spleen and brain. By p53, camptothecin, stroke injury and infection with coxsackievirus B3. This up-regulation is sufficient to induce apoptosis in neural tissue. Phosphorylated by ABL2/ARG in response to oxidative stress. [Isoform 2]: Mouse isoform 2 has been shown to have no pro-apoptotic activity. virus receptor activity tumor necrosis factor receptor binding CD27 receptor binding nucleus nucleoplasm cytoplasm mitochondrion apoptotic process activation-induced cell death of T cells zinc ion binding negative regulation of NF-kappaB transcription factor activity viral entry into host cell metal ion binding extrinsic apoptotic signaling pathway positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway uc007pev.1 uc007pev.2 uc007pev.3 uc007pev.4 
ENSMUST00000021729.9 Gpr132 ENSMUST00000021729.9 G protein-coupled receptor 132 (from RefSeq NM_019925.4) ENSMUST00000021729.1 ENSMUST00000021729.2 ENSMUST00000021729.3 ENSMUST00000021729.4 ENSMUST00000021729.5 ENSMUST00000021729.6 ENSMUST00000021729.7 ENSMUST00000021729.8 G2a GP132_MOUSE NM_019925 Q0VBS4 Q3U5A4 Q9Z282 uc007pfk.1 uc007pfk.2 uc007pfk.3 May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity (By similarity). Cell membrane ; Multi-pass membrane protein Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface. Highly expressed in hematopoietic tissues rich in lymphocytes like spleen and thymus. Weakly expressed in heart and lung. Highly expressed in infiltrating macrophages within atherosclerotic lesions. By DNA-damaging agents. Belongs to the G-protein coupled receptor 1 family. G1/S transition of mitotic cell cycle G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway negative regulation of G2/M transition of mitotic cell cycle membrane integral component of membrane uc007pfk.1 uc007pfk.2 uc007pfk.3 
ENSMUST00000021734.9 Gng4 ENSMUST00000021734.9 guanine nucleotide binding protein (G protein), gamma 4, transcript variant 1 (from RefSeq NM_010317.3) ENSMUST00000021734.1 ENSMUST00000021734.2 ENSMUST00000021734.3 ENSMUST00000021734.4 ENSMUST00000021734.5 ENSMUST00000021734.6 ENSMUST00000021734.7 ENSMUST00000021734.8 GBG4_MOUSE Gngt4 NM_010317 P50153 uc007pml.1 uc007pml.2 uc007pml.3 uc007pml.4 This gene encodes the gamma subunit of the heterotrimeric G-proteins that are comprised of alpha, beta and gamma subunits. Upon activation by G protein-coupled receptors, the beta-gamma heterodimer dissociates from the alpha subunit to activate downstream signaling events. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3 (By similarity). Interacts with KCNK1. Cell membrane ; Lipid-anchor ; Cytoplasmic side Brain. Belongs to the G protein gamma family. GTPase activity heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane negative regulation of cell growth G-protein beta/gamma-subunit complex G-protein beta-subunit binding uc007pml.1 uc007pml.2 uc007pml.3 uc007pml.4 
ENSMUST00000021738.10 Gpr137b ENSMUST00000021738.10 G protein-coupled receptor 137B (from RefSeq NM_031999.2) A0A0R4J022 A0A0R4J022_MOUSE ENSMUST00000021738.1 ENSMUST00000021738.2 ENSMUST00000021738.3 ENSMUST00000021738.4 ENSMUST00000021738.5 ENSMUST00000021738.6 ENSMUST00000021738.7 ENSMUST00000021738.8 ENSMUST00000021738.9 Gpr137b NM_031999 uc007pmd.1 uc007pmd.2 uc007pmd.3 uc007pmd.4 Membrane ; Multi- pass membrane protein membrane integral component of membrane uc007pmd.1 uc007pmd.2 uc007pmd.3 uc007pmd.4 
ENSMUST00000021750.15 Ryr2 ENSMUST00000021750.15 ryanodine receptor 2, cardiac (from RefSeq NM_023868.2) E9Q401 ENSMUST00000021750.1 ENSMUST00000021750.10 ENSMUST00000021750.11 ENSMUST00000021750.12 ENSMUST00000021750.13 ENSMUST00000021750.14 ENSMUST00000021750.2 ENSMUST00000021750.3 ENSMUST00000021750.4 ENSMUST00000021750.5 ENSMUST00000021750.6 ENSMUST00000021750.7 ENSMUST00000021750.8 ENSMUST00000021750.9 NM_023868 O70181 Q62174 Q62197 Q9ERN6 RYR2_MOUSE Ryr2 uc007pld.1 uc007pld.2 uc007pld.3 Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671, ChEBI:CHEBI:29108; Evidence= The calcium release is activated by increased cytosolic calcium levels, by nitric oxyde (NO), caffeine and ATP. Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites. Homotetramer. Can also form heterotetramers with RYR1 and RYR3. Interacts with CALM and S100A1; these interactions regulate channel activity. Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with FKBP1B, PKA, PP1 and PP2A (By similarity). Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca(2+) leaks. Interacts with SELENON (By similarity). Identified in a complex, composed of FSD2, CMYA5 and RYR2 (PubMed:28740084). E9Q401; Q6PHZ2: Camk2d; NbExp=2; IntAct=EBI-643628, EBI-2308458; E9Q401; Q9Z2I2: Fkbp1b; NbExp=3; IntAct=EBI-643628, EBI-6379859; E9Q401; Q8K4S1: Plce1; NbExp=2; IntAct=EBI-643628, EBI-6902760; E9Q401; E9Q401: Ryr2; NbExp=7; IntAct=EBI-643628, EBI-643628; E9Q401; P23327: HRC; Xeno; NbExp=3; IntAct=EBI-643628, EBI-9639760; Sarcoplasmic reticulum membrane ; Multi-pass membrane protein Highly expressed in heart, lung, cerebellum and brain. Detected at lower levels in adrenal gland, stomach, thymus, esophagus and ovary. The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm. Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2807 and Ser-2813 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels. Phosphorylation at Ser-2030 by PKA enhances the response to lumenal calcium. Embryonically lethal. Embryos die at about 10 dpc, due to defects in heart tube development. Cardiac myotubes display enlarged rough endoplasmic reticulum and cytoplasmic vesicles that contain high levels of Ca(2+). Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily. response to hypoxia regulation of heart rate embryonic heart tube morphogenesis left ventricular cardiac muscle tissue morphogenesis cardiac muscle hypertrophy ion channel activity ryanodine-sensitive calcium-release channel activity calcium channel activity calcium ion binding detection of calcium ion protein binding calmodulin binding nuclear envelope cytoplasm endoplasmic reticulum smooth endoplasmic reticulum plasma membrane ion transport calcium ion transport cellular calcium ion homeostasis multicellular organism development positive regulation of heart rate regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of cardiac muscle contraction by calcium ion signaling release of sequestered calcium ion into cytosol by sarcoplasmic reticulum response to muscle activity calcium-release channel activity membrane integral component of membrane sarcoplasmic reticulum calcium-mediated signaling enzyme binding protein kinase binding sarcomere Z disc cytoplasmic vesicle membrane response to caffeine extrinsic component of cytoplasmic side of plasma membrane A band response to magnesium ion macromolecular complex sarcoplasmic reticulum membrane ion transmembrane transport protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding calcium channel complex calcium-mediated signaling using intracellular calcium source response to muscle stretch sarcolemma identical protein binding neuron projection protein self-association suramin binding calcium-induced calcium release activity release of sequestered calcium ion into cytosol positive regulation of sequestering of calcium ion regulation of cytosolic calcium ion concentration negative regulation of cytosolic calcium ion concentration response to calcium ion response to redox state transmembrane transport regulation of cardiac muscle contraction cardiac muscle contraction cytosolic calcium ion transport calcium ion transport into cytosol sarcoplasmic reticulum calcium ion transport calcium ion transmembrane transport cellular response to caffeine manganese ion transmembrane transport cellular response to epinephrine stimulus establishment of protein localization to endoplasmic reticulum ventricular cardiac muscle cell action potential Purkinje myocyte to ventricular cardiac muscle cell signaling type B pancreatic cell apoptotic process scaffold protein binding organic cyclic compound binding positive regulation of the force of heart contraction regulation of AV node cell action potential regulation of SA node cell action potential regulation of atrial cardiac muscle cell action potential regulation of ventricular cardiac muscle cell action potential positive regulation of calcium-transporting ATPase activity uc007pld.1 uc007pld.2 uc007pld.3 
ENSMUST00000021757.5 Aoah ENSMUST00000021757.5 acyloxyacyl hydrolase, transcript variant 1 (from RefSeq NM_012054.4) AOAH_MOUSE Aoah ENSMUST00000021757.1 ENSMUST00000021757.2 ENSMUST00000021757.3 ENSMUST00000021757.4 NM_012054 O35298 uc007ppu.1 uc007ppu.2 uc007ppu.3 uc007ppu.4 This genes encodes an enzyme that catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides. The encoded protein modulates host inflammatory response to gram-negative bacteria. The proprotein is further cleaved into a large and small chain that interact in a heterodimer. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2013]. Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPS) (PubMed:12810692, PubMed:15155618, PubMed:17322564, PubMed:19860560). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (PubMed:17322564, PubMed:19860560, PubMed:28622363). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (PubMed:18779055). Reaction=a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = 3- hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+); Xref=Rhea:RHEA:12032, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:136853, ChEBI:CHEBI:140675; EC=3.1.1.77; Evidence= Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per subunit. The calcium ions probably have a structural role. ; Heterodimer of the large and small subunits; disulfide-linked. Secreted Cytoplasmic vesicle Note=Detected in urine. Detected in peritoneal macrophages (at protein level) (PubMed:17322564, PubMed:28622363). Strongly expressed in kidney cortex, where it may be produced by proximal tubule cells (PubMed:15155618). In liver, expressed at high levels in Kupffer cells (PubMed:17322564). Expressed by dendritic cells (PubMed:12810692). Detected at low levels in alveolar macrophages (PubMed:28622363). Strongly up-regulated in alveolar macrophages in response to bacterial lipopolysaccharides (LPS). Cleaved into a large and a small subunit. The small subunit is N-glycosylated. Animals develop significant and prolonged hepatosplenomegaly in response to bacterial lipopolysaccharide (LPS) challenge (PubMed:17322564). Both liver and spleen show increased accumulation of leukocytes (PubMed:17322564). Significantly reduced deacylation of LPS in liver and spleen, in peritoneal macrophages, and in bone marrow-derived dendritic cells (PubMed:12810692, PubMed:17322564, PubMed:18779055). Increased lung injury, delayed neutrophil clearance, and prolonged recovery time in response to intranasal LPS administration (PubMed:28622363). Alveolar macrophages show persistent activation and cytokine levels in lung remain elevated 4-7 days after LPS administration (PubMed:28622363). Impaired response to a second infection challenge, with reduced production of the pro- inflammatory chemokines CCL5/RANTES, TNF and IL6 by peritoneal macrophages and reduced survival rates, indicating a prolonged state of immune tolerance (PubMed:18779055). This immune tolerant state can perisist for two months or longer (PubMed:18779055). calcium ion binding extracellular region lipid metabolic process fatty acid metabolic process lipopolysaccharide metabolic process lipopolysaccharide catabolic process hydrolase activity hydrolase activity, acting on ester bonds cytoplasmic vesicle metal ion binding acyloxyacyl hydrolase activity negative regulation of inflammatory response uc007ppu.1 uc007ppu.2 uc007ppu.3 uc007ppu.4 
ENSMUST00000021769.16 Slc17a4 ENSMUST00000021769.16 solute carrier family 17 (sodium phosphate), member 4 (from RefSeq NM_177016.3) B9EJP0 ENSMUST00000021769.1 ENSMUST00000021769.10 ENSMUST00000021769.11 ENSMUST00000021769.12 ENSMUST00000021769.13 ENSMUST00000021769.14 ENSMUST00000021769.15 ENSMUST00000021769.2 ENSMUST00000021769.3 ENSMUST00000021769.4 ENSMUST00000021769.5 ENSMUST00000021769.6 ENSMUST00000021769.7 ENSMUST00000021769.8 ENSMUST00000021769.9 NM_177016 Q5NCM1 S17A4_MOUSE uc007pvh.1 uc007pvh.2 uc007pvh.3 Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions (PubMed:22460716). Mediates chloride-dependent transport of urate (PubMed:22460716). Mediates sodium-independent high affinity transport of thyroid hormones including L-thyroxine (T4) and 3,3',5-triiodo-L- thyronine (T3) (By similarity). Can actively transport inorganic phosphate into cells via Na(+) cotransport (By similarity). Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in); Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; Evidence=; Reaction=n chloride(in) + urate(out) = n chloride(out) + urate(in); Xref=Rhea:RHEA:72319, ChEBI:CHEBI:17775, ChEBI:CHEBI:17996; Evidence=; Reaction=L-thyroxine(out) = L-thyroxine(in); Xref=Rhea:RHEA:71819, ChEBI:CHEBI:58448; Evidence=; Reaction=3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L- thyronine(in); Xref=Rhea:RHEA:71811, ChEBI:CHEBI:533015; Evidence=; Apical cell membrane ; Multi-pass membrane protein Note=Apical in the intestinal brush border. Expressed in the small intestine (at protein level). Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. Sequence=CAI35970.1; Type=Erroneous gene model prediction; Evidence=; plasma membrane integral component of plasma membrane ion transport sodium ion transport symporter activity membrane integral component of membrane apical plasma membrane transmembrane transport uc007pvh.1 uc007pvh.2 uc007pvh.3 
ENSMUST00000021770.8 Scgn ENSMUST00000021770.8 secretagogin, EF-hand calcium binding protein (from RefSeq NM_145399.1) ENSMUST00000021770.1 ENSMUST00000021770.2 ENSMUST00000021770.3 ENSMUST00000021770.4 ENSMUST00000021770.5 ENSMUST00000021770.6 ENSMUST00000021770.7 NM_145399 Q91WD9 SEGN_MOUSE uc007pvk.1 uc007pvk.2 uc007pvk.3 Cytoplasm. Secreted Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions (By similarity). calcium ion binding extracellular region nucleus cytoplasm cytosol membrane dendrite transport vesicle membrane cytoplasmic vesicle neuron projection synapse metal ion binding presynapse regulation of presynaptic cytosolic calcium ion concentration regulation of long-term synaptic potentiation uc007pvk.1 uc007pvk.2 uc007pvk.3 
ENSMUST00000021772.4 Mrs2 ENSMUST00000021772.4 MRS2 magnesium transporter (from RefSeq NM_001013389.2) ENSMUST00000021772.1 ENSMUST00000021772.2 ENSMUST00000021772.3 Gm902 MRS2_MOUSE Mrs2l NM_001013389 Q5NCE8 uc007pwt.1 uc007pwt.2 uc007pwt.3 uc007pwt.4 uc007pwt.5 Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. Mitochondrion inner membrane ; Multi-pass membrane protein Ubiquitously expressed. Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. Sequence=CAI35077.1; Type=Erroneous initiation; Evidence=; mitochondrion mitochondrial inner membrane lactate metabolic process ion transport magnesium ion transmembrane transporter activity magnesium ion transport membrane integral component of membrane mitochondrial magnesium ion transport uc007pwt.1 uc007pwt.2 uc007pwt.3 uc007pwt.4 uc007pwt.5 
ENSMUST00000021773.13 Gpld1 ENSMUST00000021773.13 glycosylphosphatidylinositol specific phospholipase D1 (from RefSeq NM_008156.2) ENSMUST00000021773.1 ENSMUST00000021773.10 ENSMUST00000021773.11 ENSMUST00000021773.12 ENSMUST00000021773.2 ENSMUST00000021773.3 ENSMUST00000021773.4 ENSMUST00000021773.5 ENSMUST00000021773.6 ENSMUST00000021773.7 ENSMUST00000021773.8 ENSMUST00000021773.9 Gpld1 NM_008156 Q8VCU2 Q8VCU2_MOUSE uc007pws.1 uc007pws.2 uc007pws.3 Reaction=an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D- myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+); Xref=Rhea:RHEA:10832, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57997, ChEBI:CHEBI:58608, ChEBI:CHEBI:58700; EC=3.1.4.50; Evidence=; Secreted Belongs to the GPLD1 family. cell migration involved in sprouting angiogenesis complement receptor mediated signaling pathway glycosylphosphatidylinositol phospholipase D activity phospholipase D activity extracellular region extracellular space cytoplasm GPI anchor release negative regulation of cell proliferation insulin receptor signaling pathway response to glucose positive regulation of endothelial cell migration cellular response to insulin stimulus cellular response to drug positive regulation of apoptotic process intracellular membrane-bounded organelle positive regulation of cytolysis positive regulation of membrane protein ectodomain proteolysis cellular response to calcium ion cellular response to cholesterol cellular response to triglyceride cellular response to pH regulation of cellular response to insulin stimulus uc007pws.1 uc007pws.2 uc007pws.3 
ENSMUST00000021776.4 Prl7d1 ENSMUST00000021776.4 prolactin family 7, subfamily d, member 1, transcript variant 2 (from RefSeq NM_001360090.1) ENSMUST00000021776.1 ENSMUST00000021776.2 ENSMUST00000021776.3 NM_001360090 Plfr Prl7d1 Q9DAY8 Q9DAY8_MOUSE uc007pyc.1 uc007pyc.2 uc007pyc.3 uc007pyc.4 Secreted Belongs to the somatotropin/prolactin family. hormone activity extracellular region signal transduction uc007pyc.1 uc007pyc.2 uc007pyc.3 uc007pyc.4 
ENSMUST00000021778.14 Prl2c5 ENSMUST00000021778.14 prolactin family 2, subfamily c, member 5, transcript variant 2 (from RefSeq NM_181852.2) ENSMUST00000021778.1 ENSMUST00000021778.10 ENSMUST00000021778.11 ENSMUST00000021778.12 ENSMUST00000021778.13 ENSMUST00000021778.2 ENSMUST00000021778.3 ENSMUST00000021778.4 ENSMUST00000021778.5 ENSMUST00000021778.6 ENSMUST00000021778.7 ENSMUST00000021778.8 ENSMUST00000021778.9 Mrp4 Mrpplf4 NM_181852 PR2C5_MOUSE Plf4 Prl2c5 Q3UKX5 Q9JLV9 uc007ply.1 uc007ply.2 uc007ply.3 uc007ply.4 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JLV9-1; Sequence=Displayed; Name=2; IsoId=Q9JLV9-2; Sequence=VSP_058802; Expressed in placenta (at protein level) (PubMed:10803597, PubMed:10537154, PubMed:16876275). Expressed in the tail hair follicle, with highest expression detected in the keratinocytes of the outer root sheath (PubMed:10803597). Expressed in ear skin with lesser amounts in small intestine (PubMed:10803597). Not detected in brain at 18 dpc, postnatal day 25 or postnatal day 55 (PubMed:16876275). In placenta, detected at 8 dpc, peaks at 12 dpc and declines thereafter. N-glycosylated and sialylated. Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007ply.1 uc007ply.2 uc007ply.3 uc007ply.4 
ENSMUST00000021779.8 Prl4a1 ENSMUST00000021779.8 prolactin family 4, subfamily a, member 1 (from RefSeq NM_011165.4) ENSMUST00000021779.1 ENSMUST00000021779.2 ENSMUST00000021779.3 ENSMUST00000021779.4 ENSMUST00000021779.5 ENSMUST00000021779.6 ENSMUST00000021779.7 NM_011165 O35256 PR4A1_MOUSE Prlpa uc007pyg.1 uc007pyg.2 uc007pyg.3 Secreted Expressed specifically in placenta. Expressed in both trophoblast giant cells and spongiotrophoblast cells. Low level on day 8, abundant on days 10 to 14, and decreases by day 16. Belongs to the somatotropin/prolactin family. response to hypoxia prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pyg.1 uc007pyg.2 uc007pyg.3 
ENSMUST00000021785.8 Exoc2 ENSMUST00000021785.8 exocyst complex component 2, transcript variant 1 (from RefSeq NM_025588.2) ENSMUST00000021785.1 ENSMUST00000021785.2 ENSMUST00000021785.3 ENSMUST00000021785.4 ENSMUST00000021785.5 ENSMUST00000021785.6 ENSMUST00000021785.7 EXOC2_MOUSE NM_025588 Q9D4H1 Sec5 Sec5l1 uc007pzd.1 uc007pzd.2 uc007pzd.3 Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (PubMed:26582389). Interacts with EXOC3L1 (PubMed:18480549). Interacts with GNEFR/DELGEF; this interaction occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP (By similarity). Interacts with RALA and RALB (By similarity) (PubMed:18480549). Interacts with ARL13B; regulates ARL13B localization to the cilium membrane. Midbody, Midbody ring Note=Recruitment to the midbody does not require RALA, nor RALB. Colocalizes with CNTRL/centriolin at the midbody ring. Interacts with RALA through the TIG domain. Belongs to the SEC5 family. exocyst plasma membrane exocytosis Golgi to plasma membrane transport protein transport vesicle-mediated transport Ral GTPase binding protein kinase binding positive regulation of exocytosis protein N-terminus binding Flemming body regulation of entry of bacterium into host cell uc007pzd.1 uc007pzd.2 uc007pzd.3 
ENSMUST00000021787.7 Tfap2a ENSMUST00000021787.7 transcription factor AP-2, alpha, transcript variant 3 (from RefSeq NM_001122948.2) ENSMUST00000021787.1 ENSMUST00000021787.2 ENSMUST00000021787.3 ENSMUST00000021787.4 ENSMUST00000021787.5 ENSMUST00000021787.6 NM_001122948 Q8BPN4 Q8BPN4_MOUSE Tcfap2a Tfap2a uc007qee.1 uc007qee.2 uc007qee.3 uc007qee.4 uc007qee.5 This gene is a member of the activator protein 2 (AP-2) transcription factor family. The protein encoded by this gene can act as both an activator and repressor of gene transcription, and plays an important role in early embryogenesis, specifically in cranial development. This protein forms both homodimers and heterodimers, and binds to a GC-rich consensus sequence found in some promoters and enhancers. Disruption of this gene causes perinatal death, with neural tube, craniofacial, and limb mesenchyme defects. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]. Nucleus Belongs to the AP-2 family. transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated uc007qee.1 uc007qee.2 uc007qee.3 uc007qee.4 uc007qee.5 
ENSMUST00000021790.7 Tmem14c ENSMUST00000021790.7 transmembrane protein 14C, transcript variant 1 (from RefSeq NM_025387.3) ENSMUST00000021790.1 ENSMUST00000021790.2 ENSMUST00000021790.3 ENSMUST00000021790.4 ENSMUST00000021790.5 ENSMUST00000021790.6 NM_025387 Q543H6 Q9CQN6 Q9D849 TM14C_MOUSE uc007qet.1 uc007qet.2 uc007qet.3 uc007qet.4 Required for normal heme biosynthesis. Mitochondrion membrane ; Multi-pass membrane protein Belongs to the TMEM14 family. molecular_function mitochondrion mitochondrial inner membrane heme biosynthetic process mitochondrial transport membrane integral component of membrane erythrocyte differentiation mitochondrial membrane regulation of heme biosynthetic process uc007qet.1 uc007qet.2 uc007qet.3 uc007qet.4 
ENSMUST00000021791.8 Gcm2 ENSMUST00000021791.8 glial cells missing homolog 2 (from RefSeq NM_008104.2) A0A0R4J021 A0A0R4J021_MOUSE ENSMUST00000021791.1 ENSMUST00000021791.2 ENSMUST00000021791.3 ENSMUST00000021791.4 ENSMUST00000021791.5 ENSMUST00000021791.6 ENSMUST00000021791.7 Gcm2 NM_008104 uc007qfa.1 uc007qfa.2 uc007qfa.3 RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cellular calcium ion homeostasis cellular phosphate ion homeostasis sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter parathyroid gland development uc007qfa.1 uc007qfa.2 uc007qfa.3 
ENSMUST00000021793.15 Elovl2 ENSMUST00000021793.15 ELOVL fatty acid elongase 2, transcript variant 1 (from RefSeq NM_019423.2) ELOV2_MOUSE ENSMUST00000021793.1 ENSMUST00000021793.10 ENSMUST00000021793.11 ENSMUST00000021793.12 ENSMUST00000021793.13 ENSMUST00000021793.14 ENSMUST00000021793.2 ENSMUST00000021793.3 ENSMUST00000021793.4 ENSMUST00000021793.5 ENSMUST00000021793.6 ENSMUST00000021793.7 ENSMUST00000021793.8 ENSMUST00000021793.9 Elovl2 NM_019423 Q9D5Z2 Q9JLJ4 Ssc2 uc007qfb.1 uc007qfb.2 uc007qfb.3 uc007qfb.4 Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Essential for the formation of C24:5(n-6) up to C30:5(n-6) PUFAs in testis, these fatty acids being indispensable for normal spermatogenesis and fertility. Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long- chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=2.3.1.199; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32728; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36475, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:57384, ChEBI:CHEBI:73852; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36476; Evidence=; Reaction=(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36479, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:73856, ChEBI:CHEBI:73857; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36480; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36483, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:73862, ChEBI:CHEBI:73863; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36484; Evidence=; Reaction=(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36491, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:73870, ChEBI:CHEBI:73871; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36492; Evidence=; Lipid metabolism; polyunsaturated fatty acid biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Highly expressed in testis, lower level in liver. Weakly expressed in white adipose tissue, brain and kidney. The C-terminal di-lysine motif may confer endoplasmic reticulum localization. Belongs to the ELO family. ELOVL2 subfamily. Sequence=BAB29559.1; Type=Erroneous initiation; Evidence=; very long-chain fatty acid metabolic process endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process fatty acid elongase activity membrane integral component of membrane transferase activity transferase activity, transferring acyl groups other than amino-acyl groups fatty acid elongation, saturated fatty acid sphingolipid biosynthetic process integral component of endoplasmic reticulum membrane fatty acid elongation, monounsaturated fatty acid fatty acid elongation, polyunsaturated fatty acid very long-chain fatty acid biosynthetic process 3-oxo-arachidoyl-CoA synthase activity 3-oxo-cerotoyl-CoA synthase activity 3-oxo-lignoceronyl-CoA synthase activity uc007qfb.1 uc007qfb.2 uc007qfb.3 uc007qfb.4 
ENSMUST00000021794.14 Nedd9 ENSMUST00000021794.14 neural precursor cell expressed, developmentally down-regulated gene 9, transcript variant 1 (from RefSeq NM_001111324.2) CASL_MOUSE Casl ENSMUST00000021794.1 ENSMUST00000021794.10 ENSMUST00000021794.11 ENSMUST00000021794.12 ENSMUST00000021794.13 ENSMUST00000021794.2 ENSMUST00000021794.3 ENSMUST00000021794.4 ENSMUST00000021794.5 ENSMUST00000021794.6 ENSMUST00000021794.7 ENSMUST00000021794.8 ENSMUST00000021794.9 NM_001111324 Nedd9 O35177 Q8BJL8 Q8BK90 Q8BL52 Q8BM94 Q8BMI9 Q99KE7 uc007qfe.1 uc007qfe.2 uc007qfe.3 uc007qfe.4 uc007qfe.5 Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (By similarity). As a focal adhesion protein, plays a role in embryonic fibroblast migration (PubMed:25059660). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKl and SHPTP2 to the tyrosine phosphorylated form (By similarity). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:16148091, PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (PubMed:27359298). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA- mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (By similarity). Positively regulates RANKL-induced osteoclastogenesis (PubMed:27336669). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (PubMed:26683084). Homodimer (By similarity). Forms heterodimers with BCAR1/p130cas (By similarity). Forms complexes with PTK2B/RAFTK, adapter protein CRKL and LYN kinase (By similarity). Part of a complex composed of NEDD9, AURKA and CTTN; within the complex NEDD9 acts as a scaffold protein and is required for complex formation (By similarity). Part of a ternary complex composed of SMAD3, ITCH/AIP4 and NEDD9/HEF1; within the complex NEDD9/HEF1 interacts (via N-terminus) with ITCH/AIP4 (via WW domains); the complex mediates ubiquitination and proteasomal degradation of NEDD9/HEF1 (By similarity). Interacts with SMAD3; the interaction promotes NEDD9 ubiquitination and proteasomal degradation (By similarity). Interacts with ID2 (By similarity). Interacts with CTTN (via N-terminus) (PubMed:24574519). Interacts with MICAL (By similarity). Interacts with TXNL4/DIM1 (By similarity). Interacts with BCAR3 (via Ras-GEF domain) (PubMed:12517963, PubMed:19103205). Interacts with SH2D3C isoform 1 and isoform 2 (PubMed:10692442, PubMed:17174122). Interacts with ECT2 (By similarity). Interacts with PTPN11/SHP-2 (via SH2 domains); the interaction is enhanced when NEDD9/CAS-L is tyrosine phosphorylated (By similarity). Interacts (via C-terminus) with PLK1 (via polo box domains) (PubMed:29191835). Interacts with NKX2-5 (By similarity). Interacts with SMAD3; the interaction is inhibited by oxidation of NEDD9 (By similarity). Interacts with NEDD9/HEF1; interaction is induced by CXCL12 promotion of ABL-mediated phosphorylation of NEDD9/HEF1 (By similarity). Interacts (via SH3 domain) with PTK2/FAK (PubMed:25059660). Interacts with FYN; in the presence of PTK2 (By similarity). Interacts with INPPL1/SHIP2 (By similarity). O35177; Q9QZS8: Sh2d3c; NbExp=2; IntAct=EBI-2642891, EBI-7964037; Cytoplasm, cell cortex Nucleus Golgi apparatus Cell projection, lamellipodium Cytoplasm Cell junction, focal adhesion Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, spindle pole Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Basolateral cell membrane Expressed in splenic lymphocytes (at protein level) (PubMed:19365570). Expressed in T-cells (at protein level) (PubMed:27359298). Expressed in the thymus (PubMed:16148091). Expressed throughout the brain however particularly abundant in the cortex and hippocampus (PubMed:26683084). Induced by TGF-beta treatment in bone marrow macrophages. Contains a central domain containing multiple potential SH2- binding sites and a C-terminal domain containing a divergent helix- loop-helix (HLH) motif (By similarity). The SH2-binding sites putatively bind CRKL SH2 domains (By similarity). The HLH motif confers specific interaction with the HLH protein ID2 (By similarity). It is absolutely required for the induction of pseudohyphal growth in yeast and mediates homodimerization and heterodimerization with BCAR1/p130cas (By similarity). Polyubiquitinated by ITCH/AIP4, leading to proteasomal degradation. PTK2/FAK1 phosphorylates the protein at the YDYVHL motif (conserved among all cas proteins) following integrin stimulation (By similarity). The SRC family kinases (FYN, SRC, LCK and CRK) are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues (By similarity). Ligation of either integrin beta-1 or B-cell antigen receptor on tonsillar B-cells and B-cell lines promotes tyrosine phosphorylation and both integrin and BCR-mediated tyrosine phosphorylation requires an intact actin network (By similarity). Phosphorylation is required to recruit NEDD9 to T-cell receptor microclusters at the periphery of newly formed immunological synapses (PubMed:27359298). In fibroblasts transformation with oncogene v-ABL results in an increase in tyrosine phosphorylation. Transiently phosphorylated following CD3 cross-linking and this phosphorylated form binds to CRKL and C3G (By similarity). A mutant lacking the SH3 domain is phosphorylated upon CD3 cross-linking but not upon integrin beta-1 cross-linking. Tyrosine phosphorylation occurs upon stimulation of the G-protein coupled C1a calcitonin receptor. Calcitonin-stimulated tyrosine phosphorylation is mediated by calcium- and protein kinase C- dependent mechanisms and requires the integrity of the actin cytoskeleton. Phosphorylation at Ser-368 induces proteasomal degradation (By similarity). Phosphorylated by LYN (By similarity). Phosphorylation at Ser-779 by CSNK1D or CSNK1E, or phosphorylation of Thr-803 by CSNK1E enhances the interaction of NEDD9 with PLK1 (By similarity). Knockout mice are morphologically normal and fertile, however take an increased amount of time to learn new spatial memories (PubMed:26683084). Reduced dendritic spine density in the dentate gyrus and both the basal and apical CA1 regions of the hippocampus, with additional decreased in apical dendrite length (PubMed:26683084). The difference in dendritic spine density becomes more pronounced with age (PubMed:26683084). Reduced numbers of osteoclasts in bone marrow macrophages, however overall displayed a normal skeletal phenotype (PubMed:27336669). Abolishes ICAM1 distribution at the pericentral ring of the immunological synapse of T- cells (PubMed:27359298). Impaired movement of T-cell receptor (TCR) microclusters from the synapse periphery to the central region and a decrease in TCR microcluster maturation (PubMed:27359298). Decreased Ca(2+) release from intracellular stores and decreased PLCG1 activation during synapse formation. T-cells failed to form stable immunological synapses, tended to polarize and exhibited uncoordinated, slow migration resulting in significantly smaller synapse area (PubMed:27359298). T-cells show a disorganized cortical actin network, smaller lamellipodial area and undefined lamella boundaries (PubMed:27359298). Decreased splenic follicular and marginal zone B- cells (MZB), however MZB cells were more significantly affected, leading to a decrease in phosphorylcholine-specific IgM and IgG2a (PubMed:16148091). Reduced chemotaxis of T-cells and follicular B-cells in response to CXCL12 and CXCL13 and reduced cell adhesion in response to the integrin ligands VCAM1 and ICAM1 (PubMed:16148091). Decreased number of homing B- and T-cells in the spleen, lymph nodes and peripheral blood, with elevated B-cells in the peripheral blood (PubMed:16148091). Belongs to the CAS family. spindle pole protein binding nucleus nucleoplasm cytoplasm cytosol cytoskeleton plasma membrane cell cortex cell cycle cell adhesion cell migration positive regulation of cell migration regulation of growth cell division positive regulation of protein tyrosine kinase activity actin filament reorganization activation of GTPase activity positive regulation of substrate adhesion-dependent cell spreading protein tyrosine kinase binding uc007qfe.1 uc007qfe.2 uc007qfe.3 uc007qfe.4 uc007qfe.5 
ENSMUST00000021796.9 Edn1 ENSMUST00000021796.9 endothelin 1 (from RefSeq NM_010104.4) ENSMUST00000021796.1 ENSMUST00000021796.2 ENSMUST00000021796.3 ENSMUST00000021796.4 ENSMUST00000021796.5 ENSMUST00000021796.6 ENSMUST00000021796.7 ENSMUST00000021796.8 Edn1 NM_010104 Q544E0 Q544E0_MOUSE preproET uc007qfl.1 uc007qfl.2 uc007qfl.3 uc007qfl.4 This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a peptide before secretion by the vascular endothelial cells. The mature peptide has various biological activities such as vasoconstriction, cell proliferation, stimulation of hormone release and modulation of central nervous activity. Mice lacking the encoded protein exhibit neonatal lethality accompanied with numerous craniofacial and cardiovascular defects due to disruption in cranial and cardiac neural crest cell patterning during early embryogenesis. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC029547.1, AK040778.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Secreted Belongs to the endothelin/sarafotoxin family. negative regulation of transcription from RNA polymerase II promoter prostaglandin biosynthetic process response to hypoxia histamine secretion regulation of systemic arterial blood pressure by endothelin cytokine activity hormone activity extracellular region extracellular space cytoplasm cell surface receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling regulation of blood pressure positive regulation of cell proliferation response to ozone multicellular organism aging positive regulation of heart rate positive regulation of cardiac muscle hypertrophy negative regulation of gene expression positive regulation of receptor biosynthetic process phosphatidylinositol 3-kinase signaling response to activity artery smooth muscle contraction vein smooth muscle contraction regulation of vasoconstriction sensory perception of pain calcium-mediated signaling peptide hormone secretion nitric oxide transport positive regulation of cell migration endothelin A receptor binding endothelin B receptor binding negative regulation of cellular protein metabolic process positive regulation of prostaglandin secretion response to lipopolysaccharide Weibel-Palade body response to testosterone negative regulation of smooth muscle cell apoptotic process response to prostaglandin F response to nicotine intracellular signal transduction cellular response to drug response to muscle stretch epithelial fluid transport vasoconstriction protein kinase C deactivation positive regulation of odontogenesis response to drug superoxide anion generation response to amino acid positive regulation of MAP kinase activity positive regulation of JUN kinase activity response to leptin basal part of cell positive regulation of cell size positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle contraction positive regulation of hormone secretion negative regulation of hormone secretion inositol phosphate-mediated signaling rough endoplasmic reticulum lumen positive regulation of smooth muscle cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of nitric-oxide synthase biosynthetic process membrane depolarization regulation of sensory perception of pain maternal process involved in parturition positive regulation of sarcomere organization positive regulation of prostaglandin-endoperoxide synthase activity positive regulation of cell growth involved in cardiac muscle cell development cellular response to calcium ion cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to peptide hormone stimulus cellular response to glucocorticoid stimulus cellular response to mineralocorticoid stimulus cellular response to fatty acid cellular response to hypoxia response to dexamethasone response to transforming growth factor beta cellular response to transforming growth factor beta stimulus positive regulation of neutrophil chemotaxis positive regulation of NIK/NF-kappaB signaling response to salt positive regulation of vascular smooth muscle cell proliferation uc007qfl.1 uc007qfl.2 uc007qfl.3 uc007qfl.4 
ENSMUST00000021797.9 Tbc1d7 ENSMUST00000021797.9 TBC1 domain family, member 7, transcript variant 2 (from RefSeq NM_025935.3) B7ZNC1 ENSMUST00000021797.1 ENSMUST00000021797.2 ENSMUST00000021797.3 ENSMUST00000021797.4 ENSMUST00000021797.5 ENSMUST00000021797.6 ENSMUST00000021797.7 ENSMUST00000021797.8 NM_025935 Q05AE0 Q3U0V0 Q9D0K0 TBCD7_MOUSE Tbc1d7 uc007qfu.1 uc007qfu.2 uc007qfu.3 uc007qfu.4 uc007qfu.5 Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:22795129). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (By similarity). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (By similarity). Component of the TSC-TBC complex (also named Rhebulator complex), composed of 2 molecules of TSC1, 2 molecules of TSC2 and 1 molecule of TBC1D7 (PubMed:22795129). Interacts with TSC1 (via C- terminal half of the coiled-coil domain) (By similarity). Lysosome membrane Cytoplasmic vesicle Cytoplasm, cytosol Note=Localizes in the cytoplasmic vesicles of the endomembrane in association with the TSC-TBC complex. Recruited to lysosomal membranes in a RHEB-dependent process in absence of nutrients. In response to nutrients, the complex dissociates from lysosomal membranes and relocalizes to the cytosol. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D0K0-1; Sequence=Displayed; Name=2; IsoId=Q9D0K0-2; Sequence=VSP_044187; GTPase activator activity Rab GTPase binding positive regulation of protein ubiquitination cytoplasmic vesicle negative regulation of TOR signaling ciliary basal body positive regulation of GTPase activity response to growth factor activation of GTPase activity negative regulation of cilium assembly uc007qfu.1 uc007qfu.2 uc007qfu.3 uc007qfu.4 uc007qfu.5 
ENSMUST00000021800.6 Mcur1 ENSMUST00000021800.6 mitochondrial calcium uniporter regulator 1 (from RefSeq NM_001081059.3) Ccdc90a ENSMUST00000021800.1 ENSMUST00000021800.2 ENSMUST00000021800.3 ENSMUST00000021800.4 ENSMUST00000021800.5 MCUR1_MOUSE Mcur1 NM_001081059 Q14DH8 Q3V3D3 Q9CXD6 uc007qgf.1 uc007qgf.2 uc007qgf.3 uc007qgf.4 Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex). Interacts (via coiled coil regions) with MCU; the interaction is direct. Interacts with SMDT1/EMRE; the interaction is direct. Interacts with PPIF. Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9CXD6-1; Sequence=Displayed; Name=2; IsoId=Q9CXD6-2; Sequence=VSP_027001, VSP_027002; Name=3; IsoId=Q9CXD6-3; Sequence=VSP_027000; Conditional knockout mice lacking Mcur1 in cardiomyocytes and endothelial cells are viable and are born at the expected Mendelian. They however show impaired mitochondrial calcium uptake and mitochondrial calcium uniporter (MCU) current. Belongs to the CCDC90 family. molecular_function mitochondrion mitochondrial inner membrane ion transport calcium ion transport mitochondrial calcium ion transport membrane integral component of membrane integral component of mitochondrial inner membrane mitochondrial calcium uptake positive regulation of mitochondrial calcium ion concentration calcium ion import uc007qgf.1 uc007qgf.2 uc007qgf.3 uc007qgf.4 
ENSMUST00000021802.16 Cap2 ENSMUST00000021802.16 cyclase associated actin cytoskeleton regulatory protein 2 (from RefSeq NM_026056.4) CAP2_MOUSE ENSMUST00000021802.1 ENSMUST00000021802.10 ENSMUST00000021802.11 ENSMUST00000021802.12 ENSMUST00000021802.13 ENSMUST00000021802.14 ENSMUST00000021802.15 ENSMUST00000021802.2 ENSMUST00000021802.3 ENSMUST00000021802.4 ENSMUST00000021802.5 ENSMUST00000021802.6 ENSMUST00000021802.7 ENSMUST00000021802.8 ENSMUST00000021802.9 NM_026056 Q80YU7 Q9CYT6 Q9D6L0 uc007qhf.1 uc007qhf.2 uc007qhf.3 uc007qhf.4 May have a regulatory bifunctional role. Cell membrane ; Peripheral membrane protein Belongs to the CAP family. cell morphogenesis actin binding plasma membrane cytoskeleton organization establishment or maintenance of cell polarity actin polymerization or depolymerization adenylate cyclase binding postsynaptic density membrane cortical actin cytoskeleton identical protein binding uc007qhf.1 uc007qhf.2 uc007qhf.3 uc007qhf.4 
ENSMUST00000021803.10 Nup153 ENSMUST00000021803.10 nucleoporin 153 (from RefSeq NM_175749.2) E9Q3G8 E9Q3G8_MOUSE ENSMUST00000021803.1 ENSMUST00000021803.2 ENSMUST00000021803.3 ENSMUST00000021803.4 ENSMUST00000021803.5 ENSMUST00000021803.6 ENSMUST00000021803.7 ENSMUST00000021803.8 ENSMUST00000021803.9 NM_175749 Nup153 uc007qhj.1 uc007qhj.2 uc007qhj.3 uc007qhj.4 mitotic cell cycle chromatin binding double-stranded DNA binding annulate lamellae nuclear pore nucleolus cytosol protein import into nucleus nuclear localization sequence binding zinc ion binding Ran GTPase binding structural constituent of nuclear pore nuclear membrane macromolecular complex nuclear periphery nuclear inclusion body identical protein binding protein anchor nuclear pore central transport channel nuclear pore nuclear basket negative regulation of RNA export from nucleus metal ion binding nuclear pore complex assembly nucleoplasmic side of nuclear pore uc007qhj.1 uc007qhj.2 uc007qhj.3 uc007qhj.4 
ENSMUST00000021806.11 Tpmt ENSMUST00000021806.11 thiopurine methyltransferase (from RefSeq NM_016785.2) A0A0R4J018 A0A0R4J018_MOUSE ENSMUST00000021806.1 ENSMUST00000021806.10 ENSMUST00000021806.2 ENSMUST00000021806.3 ENSMUST00000021806.4 ENSMUST00000021806.5 ENSMUST00000021806.6 ENSMUST00000021806.7 ENSMUST00000021806.8 ENSMUST00000021806.9 NM_016785 Tpmt uc007qhq.1 uc007qhq.2 uc007qhq.3 uc007qhq.4 Reaction=S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L- homocysteine + a thiopurine S-methylether.; EC=2.1.1.67; Evidence=; Monomer. Cytoplasm Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. thiopurine S-methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity drug metabolic process methylation S-adenosyl-L-methionine binding uc007qhq.1 uc007qhq.2 uc007qhq.3 uc007qhq.4 
ENSMUST00000021807.13 Dek ENSMUST00000021807.13 DEK proto-oncogene (from RefSeq NM_025900.2) DEK_MOUSE ENSMUST00000021807.1 ENSMUST00000021807.10 ENSMUST00000021807.11 ENSMUST00000021807.12 ENSMUST00000021807.2 ENSMUST00000021807.3 ENSMUST00000021807.4 ENSMUST00000021807.5 ENSMUST00000021807.6 ENSMUST00000021807.7 ENSMUST00000021807.8 ENSMUST00000021807.9 NM_025900 Q7TNV0 Q80VC5 Q8BZV6 uc007qhw.1 uc007qhw.2 uc007qhw.3 uc007qhw.4 Involved in chromatin organization. Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA (By similarity). Nucleus Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei. Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA (By similarity). DNA binding nucleus chromatin organization histone binding contractile fiber regulation of double-strand break repair regulation of double-strand break repair via nonhomologous end joining uc007qhw.1 uc007qhw.2 uc007qhw.3 uc007qhw.4 
ENSMUST00000021810.3 Id4 ENSMUST00000021810.3 inhibitor of DNA binding 4 (from RefSeq NM_031166.3) ENSMUST00000021810.1 ENSMUST00000021810.2 Id4 NM_031166 Q544D2 Q544D2_MOUSE uc007qid.1 uc007qid.2 uc007qid.3 Heterodimer with other HLH proteins. Nucleus nucleus cytoplasm negative regulation of transcription, DNA-templated protein dimerization activity uc007qid.1 uc007qid.2 uc007qid.3 
ENSMUST00000021813.5 Barx1 ENSMUST00000021813.5 BarH-like homeobox 1 (from RefSeq NM_007526.4) BARX1_MOUSE ENSMUST00000021813.1 ENSMUST00000021813.2 ENSMUST00000021813.3 ENSMUST00000021813.4 NM_007526 O09066 P70159 Q0VF04 Q9ER42 Q9ERV2 uc007qil.1 uc007qil.2 uc007qil.3 Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity. Binds to a regulatory module of the NCAM promoter. Nucleus Expressed predominantly in the facial primordia, developing stomach, and proximal limbs. Expressed in areas of the first and second branchial arches, before any apparent cellular or morphologic differentiation. Later in development, all expressing tissue in this region, including the mesenchyme underlying the olfactory epithelium, the primary and secondary palate, the molar tooth papillae, and the stroma of the submandibular gland, appear to be derived from ectomesenchyme of neural crest origin. By day 16.5, all areas except the developing molars are BARX1-negative. In addition, BARX1 marks the area of the future stomach in the primitive gut at embryonic day 9.5, and is present in the mesenchymal wall of the stomach until embryonic day 16.5. Belongs to the BAR homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell-cell signaling tissue development anterior/posterior pattern specification negative regulation of Wnt signaling pathway epithelial cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter animal organ development spleen development anatomical structure development digestive system development uc007qil.1 uc007qil.2 uc007qil.3 
ENSMUST00000021818.9 Cenpp ENSMUST00000021818.9 centromere protein P (from RefSeq NM_025495.4) CENPP_MOUSE ENSMUST00000021818.1 ENSMUST00000021818.2 ENSMUST00000021818.3 ENSMUST00000021818.4 ENSMUST00000021818.5 ENSMUST00000021818.6 ENSMUST00000021818.7 ENSMUST00000021818.8 NM_025495 Q52KM2 Q8C647 Q9CVW9 Q9CZ92 Q9D5U7 uc007qjk.1 uc007qjk.2 uc007qjk.3 Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity). Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity). Nucleus Chromosome, centromere Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZ92-1; Sequence=Displayed; Name=2; IsoId=Q9CZ92-2; Sequence=VSP_020449, VSP_020450; Belongs to the CENP-P/CTF19 family. Sequence=BAB24472.1; Type=Frameshift; Evidence=; Sequence=BAB29620.1; Type=Erroneous initiation; Evidence=; Sequence=BAC36401.1; Type=Frameshift; Evidence=; Sequence=BC094280; Type=Frameshift; Evidence=; chromosome, centromeric region molecular_function nucleus chromosome nucleolus biological_process CENP-A containing nucleosome assembly uc007qjk.1 uc007qjk.2 uc007qjk.3 
ENSMUST00000021822.7 Ogn ENSMUST00000021822.7 osteoglycin (from RefSeq NM_008760.5) ENSMUST00000021822.1 ENSMUST00000021822.2 ENSMUST00000021822.3 ENSMUST00000021822.4 ENSMUST00000021822.5 ENSMUST00000021822.6 MIME_MOUSE NM_008760 Og Q62000 uc007qjr.1 uc007qjr.2 uc007qjr.3 Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2. Secreted, extracellular space, extracellular matrix Contains keratan sulfate. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. extracellular region extracellular space signal transduction growth factor activity extracellular matrix structural constituent conferring compression resistance uc007qjr.1 uc007qjr.2 uc007qjr.3 
ENSMUST00000021828.6 Nxnl2 ENSMUST00000021828.6 nucleoredoxin-like 2, transcript variant 1 (from RefSeq NM_029173.5) ENSMUST00000021828.1 ENSMUST00000021828.2 ENSMUST00000021828.3 ENSMUST00000021828.4 ENSMUST00000021828.5 NM_029173 NXNL2_MOUSE Q91WB0 Q9D531 uc007qme.1 uc007qme.2 uc007qme.3 May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons. In the retina, isoform 1 may be required for rod function and isoform 2 for cone viability and function. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=RdCVF2_L; IsoId=Q9D531-3; Sequence=Displayed; Name=2; Synonyms=RdCVF2, RdCVF2_S; IsoId=Q9D531-4; Sequence=VSP_053273, VSP_053274; Both isoforms are expressed in retina, in the photoreceptor layer, and throughout the olfactory sensory neuron layer of the nasal epithelium, in neurons. Also expressed at low levels in brain and testis. At 10 months of age, mutant animals show signs of photoreceptor dysfunction. The progressive loss of cone function is followed by cone cell death, while in rods, the outer segment length id reduced, but not rod cell death is not observed. At 12 months, mice present a stronger age-dependent impairment of fine odor discrimination than their wild-type counterparts. Belongs to the nucleoredoxin family. sensory perception visual perception sensory perception of smell photoreceptor cell maintenance uc007qme.1 uc007qme.2 uc007qme.3 
ENSMUST00000021832.7 Wrnip1 ENSMUST00000021832.7 Werner helicase interacting protein 1 (from RefSeq NM_030215.3) ENSMUST00000021832.1 ENSMUST00000021832.2 ENSMUST00000021832.3 ENSMUST00000021832.4 ENSMUST00000021832.5 ENSMUST00000021832.6 NM_030215 Q3TCT7 Q6PDF0 Q8BUW5 Q8BWP6 Q8BY55 Q91XU0 Q921W3 Q9EQL3 WRIP1_MOUSE Whip Wrnip1 uc007pzt.1 uc007pzt.2 uc007pzt.3 uc007pzt.4 Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys- 63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Forms homooligomers, possibly octamers. Directly interacts with POLD1, POLD2 and POLD4 (By similarity). Interacts with the N- terminal domain of WRN (By similarity). Interacts (via UBZ4-type zinc finger) with monoubiquitin and polyubiquitin. Interacts with TRIM14 and PPP6C; these interactions positively regulate the RIGI signaling pathway (By similarity). Nucleus Cytoplasm Note=Colocalizes with WRN in granular structures in the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q91XU0-1; Sequence=Displayed; Name=2 ; IsoId=Q91XU0-2; Sequence=VSP_051784, VSP_051785; Ubiquitously expressed. The UBZ4-type zinc finger binds ubiquitin. Sumoylated with SUMO1 and SUMO2/3. [Isoform 2]: Due to intron retention. Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. Sequence=AAG35725.1; Type=Frameshift; Evidence=; nucleotide binding DNA synthesis involved in DNA repair nuclear chromosome, telomeric region immune system process DNA binding protein binding ATP binding nucleus cytoplasm DNA replication DNA-dependent DNA replication DNA repair regulation of DNA repair cellular response to DNA damage stimulus enzyme activator activity hydrolase activity ATPase activity regulation of DNA-dependent DNA replication initiation identical protein binding positive regulation of catalytic activity innate immune response metal ion binding perinuclear region of cytoplasm uc007pzt.1 uc007pzt.2 uc007pzt.3 uc007pzt.4 
ENSMUST00000021834.11 Serpinb1c ENSMUST00000021834.11 serine (or cysteine) peptidase inhibitor, clade B, member 1c, transcript variant 1 (from RefSeq NM_173051.2) ENSMUST00000021834.1 ENSMUST00000021834.10 ENSMUST00000021834.2 ENSMUST00000021834.3 ENSMUST00000021834.4 ENSMUST00000021834.5 ENSMUST00000021834.6 ENSMUST00000021834.7 ENSMUST00000021834.8 ENSMUST00000021834.9 ILEUC_MOUSE NM_173051 Q5SV42 Q5SW82 Q8K3Y1 uc007pzw.1 uc007pzw.2 uc007pzw.3 uc007pzw.4 Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G (By similarity). During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). Monomer. Interacts (via C-terminus) with CASP1 and CASP4 (via CARD domain); these interactions regulate the activity of inflammatory caspases. Cytoplasm Expressed in heart. Belongs to the serpin family. Ov-serpin subfamily. Sequence=CAI25076.1; Type=Erroneous gene model prediction; Evidence=; serine-type endopeptidase inhibitor activity protein binding extracellular space cytoplasm negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity negative regulation of interleukin-1 beta secretion uc007pzw.1 uc007pzw.2 uc007pzw.3 uc007pzw.4 
ENSMUST00000021837.10 Serpinb9c ENSMUST00000021837.10 serine (or cysteine) peptidase inhibitor, clade B, member 9c, transcript variant 1 (from RefSeq NM_001164524.1) ENSMUST00000021837.1 ENSMUST00000021837.2 ENSMUST00000021837.3 ENSMUST00000021837.4 ENSMUST00000021837.5 ENSMUST00000021837.6 ENSMUST00000021837.7 ENSMUST00000021837.8 ENSMUST00000021837.9 I7HJI5 I7HJI5_MOUSE NM_001164524 Serpinb9c uc007qac.1 uc007qac.2 uc007qac.3 uc007qac.4 Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular space cytoplasm negative regulation of endopeptidase activity uc007qac.1 uc007qac.2 uc007qac.3 uc007qac.4 
ENSMUST00000021851.8 Fam217a ENSMUST00000021851.8 family with sequence similarity 217, member A (from RefSeq NM_027967.1) 1700026J04Rik ENSMUST00000021851.1 ENSMUST00000021851.2 ENSMUST00000021851.3 ENSMUST00000021851.4 ENSMUST00000021851.5 ENSMUST00000021851.6 ENSMUST00000021851.7 F8WGE0 F8WGE0_MOUSE Fam217a NM_027967 uc011yyi.1 uc011yyi.2 uc011yyi.3 uc011yyi.1 uc011yyi.2 uc011yyi.3 
ENSMUST00000021853.12 Eci3 ENSMUST00000021853.12 enoyl-Coenzyme A delta isomerase 3, transcript variant 1 (from RefSeq NM_026947.5) D3U0D8 ECI3_MOUSE ENSMUST00000021853.1 ENSMUST00000021853.10 ENSMUST00000021853.11 ENSMUST00000021853.2 ENSMUST00000021853.3 ENSMUST00000021853.4 ENSMUST00000021853.5 ENSMUST00000021853.6 ENSMUST00000021853.7 ENSMUST00000021853.8 ENSMUST00000021853.9 Eci3 NM_026947 Q78JN3 uc007qbv.1 uc007qbv.2 uc007qbv.3 Catalyzes the isomerization of trans-3-nonenoyl-CoA into trans-2-nonenoyl-CoA (PubMed:24344334). May also have activity towards other enoyl-CoA species (Probable). Reaction=a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA; Xref=Rhea:RHEA:45900, ChEBI:CHEBI:85097, ChEBI:CHEBI:85489; EC=5.3.3.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45901; Evidence=; Reaction=a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA; Xref=Rhea:RHEA:45228, ChEBI:CHEBI:58521, ChEBI:CHEBI:85097; EC=5.3.3.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45229; Evidence=; Reaction=(3E)-nonenoyl-CoA = (2E)-nonenoyl-CoA; Xref=Rhea:RHEA:46068, ChEBI:CHEBI:76292, ChEBI:CHEBI:85655; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46069; Evidence=; Peroxisome Expressed at high levels in the kidney. Also detected at very low levels in the duodenum, jejunum, ileum, heart, liver, lung, and brown adipose tissue (at protein level). In the kidney, expression seems to be localized mainly to the proximal tubule. The ACB (acyl-CoA-binding) domain is truncated and may be non- functional. Belongs to the enoyl-CoA hydratase/isomerase family. fatty-acyl-CoA binding catalytic activity dodecenoyl-CoA delta-isomerase activity peroxisome fatty acid beta-oxidation isomerase activity uc007qbv.1 uc007qbv.2 uc007qbv.3 
ENSMUST00000021854.14 Eci2 ENSMUST00000021854.14 enoyl-Coenzyme A delta isomerase 2, transcript variant 2 (from RefSeq NM_011868.3) ECI2_MOUSE ENSMUST00000021854.1 ENSMUST00000021854.10 ENSMUST00000021854.11 ENSMUST00000021854.12 ENSMUST00000021854.13 ENSMUST00000021854.2 ENSMUST00000021854.3 ENSMUST00000021854.4 ENSMUST00000021854.5 ENSMUST00000021854.6 ENSMUST00000021854.7 ENSMUST00000021854.8 ENSMUST00000021854.9 Eci2 NM_011868 Peci Q99M61 Q9D785 Q9WUR2 uc007qbx.1 uc007qbx.2 uc007qbx.3 uc007qbx.4 uc007qbx.5 Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (PubMed:24344334). Has a preference for 3-trans substrates (By similarity). Reaction=a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA; Xref=Rhea:RHEA:45900, ChEBI:CHEBI:85097, ChEBI:CHEBI:85489; EC=5.3.3.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45901; Evidence=; Reaction=a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA; Xref=Rhea:RHEA:45228, ChEBI:CHEBI:58521, ChEBI:CHEBI:85097; EC=5.3.3.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45229; Evidence=; Reaction=(3E)-nonenoyl-CoA = (2E)-nonenoyl-CoA; Xref=Rhea:RHEA:46068, ChEBI:CHEBI:76292, ChEBI:CHEBI:85655; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46069; Evidence=; Reaction=(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA; Xref=Rhea:RHEA:29847, ChEBI:CHEBI:61405, ChEBI:CHEBI:61968; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29849; Evidence=; Reaction=(3E)-tetradecenoyl-CoA = (2E)-tetradecenoyl-CoA; Xref=Rhea:RHEA:47476, ChEBI:CHEBI:61405, ChEBI:CHEBI:87710; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47477; Evidence=; Reaction=(3E)-octenoyl-CoA = (2E)-octenoyl-CoA; Xref=Rhea:RHEA:49852, ChEBI:CHEBI:62242, ChEBI:CHEBI:131962; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49853; Evidence=; Reaction=(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA; Xref=Rhea:RHEA:46044, ChEBI:CHEBI:62242, ChEBI:CHEBI:85640; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46045; Evidence=; Lipid metabolism; fatty acid beta-oxidation. [Isoform 1]: Mitochondrion [Isoform 2]: Peroxisome matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WUR2-1; Sequence=Displayed; Name=2; Synonyms=PECI ; IsoId=Q9WUR2-2; Sequence=VSP_037855; Expressed in liver and kidney (at protein level). Acetylation of Lys-60 is observed in liver mitochondria from fasted mice but not from fed mice. In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. Sequence=AAH01983.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; fatty-acyl-CoA binding catalytic activity dodecenoyl-CoA delta-isomerase activity nucleoplasm mitochondrion peroxisome peroxisomal matrix fatty acid beta-oxidation fatty acid catabolic process isomerase activity intramolecular oxidoreductase activity, transposing C=C bonds intracellular membrane-bounded organelle uc007qbx.1 uc007qbx.2 uc007qbx.3 uc007qbx.4 uc007qbx.5 
ENSMUST00000021857.13 Fars2 ENSMUST00000021857.13 phenylalanine-tRNA synthetase 2, mitochondrial, transcript variant 1 (from RefSeq NM_024274.3) ENSMUST00000021857.1 ENSMUST00000021857.10 ENSMUST00000021857.11 ENSMUST00000021857.12 ENSMUST00000021857.2 ENSMUST00000021857.3 ENSMUST00000021857.4 ENSMUST00000021857.5 ENSMUST00000021857.6 ENSMUST00000021857.7 ENSMUST00000021857.8 ENSMUST00000021857.9 Fars1 NM_024274 Q3TBZ7 Q99M01 Q9CYY0 SYFM_MOUSE uc007qck.1 uc007qck.2 uc007qck.3 uc007qck.4 Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins (By similarity). Reaction=ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe); Xref=Rhea:RHEA:19413, Rhea:RHEA-COMP:9668, Rhea:RHEA-COMP:9699, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58095, ChEBI:CHEBI:78442, ChEBI:CHEBI:78531, ChEBI:CHEBI:456215; EC=6.1.1.20; Evidence=; Monomer. Mitochondrion matrix Mitochondrion Belongs to the class-II aminoacyl-tRNA synthetase family. tRNA binding nucleotide binding aminoacyl-tRNA ligase activity phenylalanine-tRNA ligase activity ATP binding cytoplasm mitochondrion mitochondrial matrix translation phenylalanyl-tRNA aminoacylation tRNA processing ligase activity tRNA aminoacylation uc007qck.1 uc007qck.2 uc007qck.3 uc007qck.4 
ENSMUST00000021860.7 Ly86 ENSMUST00000021860.7 lymphocyte antigen 86, transcript variant 1 (from RefSeq NM_010745.3) ENSMUST00000021860.1 ENSMUST00000021860.2 ENSMUST00000021860.3 ENSMUST00000021860.4 ENSMUST00000021860.5 ENSMUST00000021860.6 LY86_MOUSE Md1 NM_010745 O88188 Q4VAF1 Q5D046 uc007qcr.1 uc007qcr.2 uc007qcr.3 uc007qcr.4 May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression. M-shaped tetramer of two CD180-LY86 heterodimers. O88188; Q62192: Cd180; NbExp=5; IntAct=EBI-79494, EBI-79487; Secreted, extracellular space. Note=Associated with CD180 at the cell surface. Highly expressed in spleen, liver, brain and thymus, and at lower levels in kidney. immune system process protein binding extracellular region extracellular space inflammatory response immune response positive regulation of lipopolysaccharide-mediated signaling pathway innate immune response uc007qcr.1 uc007qcr.2 uc007qcr.3 uc007qcr.4 
ENSMUST00000021864.8 Ssr1 ENSMUST00000021864.8 signal sequence receptor, alpha, transcript variant 1 (from RefSeq NM_025965.4) ENSMUST00000021864.1 ENSMUST00000021864.2 ENSMUST00000021864.3 ENSMUST00000021864.4 ENSMUST00000021864.5 ENSMUST00000021864.6 ENSMUST00000021864.7 NM_025965 Q3TIM3 Q99MP2 Q9CY50 SSRA_MOUSE uc011yyk.1 uc011yyk.2 uc011yyk.3 TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP- gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins (By similarity). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged. Seems to bind calcium. Belongs to the TRAP-alpha family. endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane uc011yyk.1 uc011yyk.2 uc011yyk.3 
ENSMUST00000021866.10 Riok1 ENSMUST00000021866.10 RIO kinase 1 (from RefSeq NM_024242.3) ENSMUST00000021866.1 ENSMUST00000021866.2 ENSMUST00000021866.3 ENSMUST00000021866.4 ENSMUST00000021866.5 ENSMUST00000021866.6 ENSMUST00000021866.7 ENSMUST00000021866.8 ENSMUST00000021866.9 NM_024242 Q3U7D5 Q922Q2 Q99LZ1 Q9CU84 Q9CXN9 RIOK1_MOUSE uc007qdi.1 uc007qdi.2 uc007qdi.3 uc007qdi.4 This gene encodes a member of the RIO family of atypical serine protein kinases. A similar protein in humans is a component of the protein arginine methyltransferase 5 complex that specifically recruits the RNA-binding protein nucleolin as a methylation substrate. [provided by RefSeq, Feb 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK152707.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (By similarity). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Associates with the precursor of the 40S ribosome subunit. Interacts (via its N-terminus) with PRMT5 (via its N-terminus). Interacts with WDR77 (By similarity). Found in a PRMT5 complex composed of PRMT5, WDR77 and RIOK1 (By similarity). Interacts (via its C- terminus) with NCL; this interaction targets NCL for PRTM5 methylation (By similarity). Cytoplasm, cytosol Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. Sequence=AAH02158.1; Type=Erroneous initiation; Evidence=; Sequence=BAB29195.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB29195.1; Type=Frameshift; Evidence=; Sequence=BAB29195.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAB30687.2; Type=Erroneous initiation; Evidence=; nucleotide binding protein serine/threonine kinase activity ATP binding cytoplasm cytosol protein phosphorylation kinase activity phosphorylation transferase activity hydrolase activity maturation of SSU-rRNA preribosome, small subunit precursor methyltransferase complex ribosome biogenesis ribosomal small subunit biogenesis metal ion binding positive regulation of rRNA processing uc007qdi.1 uc007qdi.2 uc007qdi.3 uc007qdi.4 
ENSMUST00000021880.10 Ctla2a ENSMUST00000021880.10 cytotoxic T lymphocyte-associated protein 2 alpha, transcript variant 1 (from RefSeq NM_007796.2) CTL2A_MOUSE ENSMUST00000021880.1 ENSMUST00000021880.2 ENSMUST00000021880.3 ENSMUST00000021880.4 ENSMUST00000021880.5 ENSMUST00000021880.6 ENSMUST00000021880.7 ENSMUST00000021880.8 ENSMUST00000021880.9 NM_007796 P12399 Q91V07 uc007qvx.1 uc007qvx.2 uc007qvx.3 Not known, expressed in activated T-cell. Secreted To the propeptide regions of cysteine proteases. Sequence=CAA33614.1; Type=Erroneous initiation; Evidence=; extracellular region negative regulation of protein processing dendrite regulation of regulatory T cell differentiation negative regulation of inflammatory response uc007qvx.1 uc007qvx.2 uc007qvx.3 
ENSMUST00000021885.8 Tpbpa ENSMUST00000021885.8 trophoblast specific protein alpha (from RefSeq NM_009411.5) ENSMUST00000021885.1 ENSMUST00000021885.2 ENSMUST00000021885.3 ENSMUST00000021885.4 ENSMUST00000021885.5 ENSMUST00000021885.6 ENSMUST00000021885.7 NM_009411 Q9CPR0 Q9CPR0_MOUSE Tpbpa uc007qvz.1 uc007qvz.2 uc007qvz.3 uc007qvz.1 uc007qvz.2 uc007qvz.3 
ENSMUST00000021888.9 Ctsq ENSMUST00000021888.9 cathepsin Q (from RefSeq NM_029636.3) CtsQ Ctsq ENSMUST00000021888.1 ENSMUST00000021888.2 ENSMUST00000021888.3 ENSMUST00000021888.4 ENSMUST00000021888.5 ENSMUST00000021888.6 ENSMUST00000021888.7 ENSMUST00000021888.8 NM_029636 Q91ZF4 Q91ZF4_MOUSE uc007qwd.1 uc007qwd.2 uc007qwd.3 uc007qwd.4 Belongs to the peptidase C1 family. cysteine-type endopeptidase activity extracellular space lysosome proteolysis cysteine-type peptidase activity proteolysis involved in cellular protein catabolic process uc007qwd.1 uc007qwd.2 uc007qwd.3 uc007qwd.4 
ENSMUST00000021889.6 Ctsr ENSMUST00000021889.6 cathepsin R (from RefSeq NM_020284.1) CATR_MOUSE Catr ENSMUST00000021889.1 ENSMUST00000021889.2 ENSMUST00000021889.3 ENSMUST00000021889.4 ENSMUST00000021889.5 NM_020284 Q9JIA9 uc007qwe.1 uc007qwe.2 uc007qwe.3 Lysosome Placenta. Expressed in adult but not in embryo. Belongs to the peptidase C1 family. cysteine-type endopeptidase activity extracellular space lysosome proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity protein catabolic process proteolysis involved in cellular protein catabolic process uc007qwe.1 uc007qwe.2 uc007qwe.3 
ENSMUST00000021890.5 Cts6 ENSMUST00000021890.5 cathepsin 6 (from RefSeq NM_021445.1) Cts6 ENSMUST00000021890.1 ENSMUST00000021890.2 ENSMUST00000021890.3 ENSMUST00000021890.4 NM_021445 Q9ET52 Q9ET52_MOUSE uc007qwf.1 uc007qwf.2 uc007qwf.3 Belongs to the peptidase C1 family. cysteine-type endopeptidase activity extracellular space lysosome proteolysis cysteine-type peptidase activity proteolysis involved in cellular protein catabolic process uc007qwf.1 uc007qwf.2 uc007qwf.3 
ENSMUST00000021891.5 Cts8 ENSMUST00000021891.5 cathepsin 8 (from RefSeq NM_019541.3) CAT8_MOUSE Cts2 Cts8 ENSMUST00000021891.1 ENSMUST00000021891.2 ENSMUST00000021891.3 ENSMUST00000021891.4 Epcs68 Epcs70 NM_019541 Q6NV96 Q9JI81 uc007qwg.1 uc007qwg.2 uc007qwg.3 uc007qwg.4 Probable protease (By similarity). In placenta, plays a role in promoting giant cell differentiation (PubMed:18776147). Also plays a role in placental spiral artery remodeling by direct degradation of smooth muscle alpha-actin (PubMed:18776147). Secreted Lysosome Endosome Note=Localizes to the cytoplasm with a punctate staining pattern indicative of a predominant lysosomal and endosomal localization. Expressed in placenta (PubMed:11829493, PubMed:10885754, PubMed:18776147). Highly expressed in a subset of trophoblast giant cells in the parietal yolk sac and at the outside of the ectoplacental cone (PubMed:10885754). Expressed at highest level in liver with lesser amounts in testis, kidney, heart, lung and brain (PubMed:10885754). Not detected in spleen and skeletal muscle (PubMed:10885754, PubMed:11829493). Not detected in blood, heart, brain, testis, liver, lung, kidney, thymus or uterus (PubMed:11829493). Detected from 5.5 dpc in parietal trophoblast giant cells (PubMed:18776147, PubMed:10885754). Detected at 8.5 dpc in placenta, and shows increased expression level from 13.5 to 19.5 dpc (PubMed:11829493). Belongs to the peptidase C1 family. blood vessel remodeling cysteine-type endopeptidase activity extracellular region extracellular space lysosome endosome proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity protein catabolic process proteolysis involved in cellular protein catabolic process trophoblast giant cell differentiation uc007qwg.1 uc007qwg.2 uc007qwg.3 uc007qwg.4 
ENSMUST00000021900.14 Sema4d ENSMUST00000021900.14 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D, transcript variant 2 (from RefSeq NM_013660.5) ENSMUST00000021900.1 ENSMUST00000021900.10 ENSMUST00000021900.11 ENSMUST00000021900.12 ENSMUST00000021900.13 ENSMUST00000021900.2 ENSMUST00000021900.3 ENSMUST00000021900.4 ENSMUST00000021900.5 ENSMUST00000021900.6 ENSMUST00000021900.7 ENSMUST00000021900.8 ENSMUST00000021900.9 NM_013660 O09126 Q6GTM9 SEM4D_MOUSE Semacl2 Semaj uc007qmo.1 uc007qmo.2 uc007qmo.3 uc007qmo.4 Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (By similarity). Regulates GABAergic synapse development (PubMed:23699507, PubMed:29981480). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (PubMed:23699507, PubMed:29981480). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity). Promotes the migration of cerebellar granule cells (PubMed:17554007). Plays a role in the immune system; induces B- cells to aggregate and improves their viability (in vitro) (By similarity). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (By similarity). Homodimer (By similarity). Interacts with PLXNB1 (By similarity). Interacts with PLXNB2 (PubMed:17554007). Cell membrane ; Single-pass type I membrane protein Strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous tissues (PubMed:8969198). Expressed in neurons and glia in the developing hippocampus (PubMed:29981480). Belongs to the semaphorin family. negative regulation of transcription from RNA polymerase II promoter neural crest cell migration positive regulation of protein phosphorylation transmembrane signaling receptor activity receptor binding protein binding extracellular space plasma membrane integral component of plasma membrane negative regulation of cell adhesion multicellular organism development nervous system development regulation of cell shape negative regulation of alkaline phosphatase activity positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane cell differentiation semaphorin receptor binding positive regulation of cell migration regulation of cell projection organization signaling receptor activity identical protein binding positive regulation of GTPase activity ossification involved in bone maturation chemorepellent activity negative regulation of osteoblast differentiation positive regulation of collateral sprouting regulation of dendrite morphogenesis negative regulation of axon extension involved in axon guidance positive regulation of peptidyl-tyrosine phosphorylation negative regulation of peptidyl-tyrosine phosphorylation positive regulation of axonogenesis negative chemotaxis leukocyte aggregation semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis positive regulation of inhibitory synapse assembly uc007qmo.1 uc007qmo.2 uc007qmo.3 uc007qmo.4 
ENSMUST00000021903.3 Gadd45g ENSMUST00000021903.3 growth arrest and DNA-damage-inducible 45 gamma (from RefSeq NM_011817.2) ENSMUST00000021903.1 ENSMUST00000021903.2 Gadd45g NM_011817 Q9R0S0 Q9R0S0_MOUSE oig37 uc007qmq.1 uc007qmq.2 uc007qmq.3 uc007qmq.4 uc007qmq.5 Belongs to the GADD45 family. activation of MAPKKK activity nucleus cytoplasm positive regulation of apoptotic process positive regulation of JNK cascade regulation of cell cycle positive regulation of p38MAPK cascade uc007qmq.1 uc007qmq.2 uc007qmq.3 uc007qmq.4 uc007qmq.5 
ENSMUST00000021907.9 Fbp2 ENSMUST00000021907.9 fructose bisphosphatase 2 (from RefSeq NM_007994.4) ENSMUST00000021907.1 ENSMUST00000021907.2 ENSMUST00000021907.3 ENSMUST00000021907.4 ENSMUST00000021907.5 ENSMUST00000021907.6 ENSMUST00000021907.7 ENSMUST00000021907.8 Fbp2 NM_007994 Q3TKP4 Q3TKP4_MOUSE uc007qxf.1 uc007qxf.2 uc007qxf.3 Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377, ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Carbohydrate biosynthesis; gluconeogenesis. Homotetramer. Interacts with ALDOA; the interaction blocks inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+). Interacts with alpha-actinin and F-actin. Cell junction Cytoplasm, myofibril, sarcomere, Z line Nucleus Belongs to the FBPase class 1 family. nucleoplasm plasma membrane carbohydrate metabolic process gluconeogenesis dephosphorylation hydrolase activity phosphatase activity fructose 1,6-bisphosphate 1-phosphatase activity phosphoric ester hydrolase activity identical protein binding uc007qxf.1 uc007qxf.2 uc007qxf.3 
ENSMUST00000021913.16 Auh ENSMUST00000021913.16 AU RNA binding protein/enoyl-coenzyme A hydratase, transcript variant 1 (from RefSeq NM_016709.3) A0A0R4J023 A0A0R4J023_MOUSE Auh ENSMUST00000021913.1 ENSMUST00000021913.10 ENSMUST00000021913.11 ENSMUST00000021913.12 ENSMUST00000021913.13 ENSMUST00000021913.14 ENSMUST00000021913.15 ENSMUST00000021913.2 ENSMUST00000021913.3 ENSMUST00000021913.4 ENSMUST00000021913.5 ENSMUST00000021913.6 ENSMUST00000021913.7 ENSMUST00000021913.8 ENSMUST00000021913.9 NM_016709 uc007qnd.1 uc007qnd.2 uc007qnd.3 Belongs to the enoyl-CoA hydratase/isomerase family. mRNA 3'-UTR binding catalytic activity enoyl-CoA hydratase activity uc007qnd.1 uc007qnd.2 uc007qnd.3 
ENSMUST00000021918.10 Ror2 ENSMUST00000021918.10 receptor tyrosine kinase-like orphan receptor 2 (from RefSeq NM_013846.4) ENSMUST00000021918.1 ENSMUST00000021918.2 ENSMUST00000021918.3 ENSMUST00000021918.4 ENSMUST00000021918.5 ENSMUST00000021918.6 ENSMUST00000021918.7 ENSMUST00000021918.8 ENSMUST00000021918.9 NM_013846 Q8C3W2 Q8C3W2_MOUSE Ror2 uc007qnj.1 uc007qnj.2 uc007qnj.3 Membrane ; Single- pass type I membrane protein Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. nucleotide binding protein kinase activity ATP binding protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway membrane integral component of membrane kinase activity phosphorylation uc007qnj.1 uc007qnj.2 uc007qnj.3 
ENSMUST00000021920.8 Sptlc1 ENSMUST00000021920.8 serine palmitoyltransferase, long chain base subunit 1, transcript variant 8 (from RefSeq NR_189737.1) ENSMUST00000021920.1 ENSMUST00000021920.2 ENSMUST00000021920.3 ENSMUST00000021920.4 ENSMUST00000021920.5 ENSMUST00000021920.6 ENSMUST00000021920.7 Lcb1 NR_189737 O35704 O54813 Q8BH11 SPTC1_MOUSE uc007qnk.1 uc007qnk.2 uc007qnk.3 uc007qnk.4 Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:28100772). The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Required for adipocyte cell viability and metabolic homeostasis (PubMed:28100772). Reaction=H(+) + hexadecanoyl-CoA + L-serine = 3-oxosphinganine + CO2 + CoA; Xref=Rhea:RHEA:14761, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:58299; EC=2.3.1.50; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14762; Evidence=; Reaction=H(+) + L-serine + octadecanoyl-CoA = 3-oxoeicosasphinganine + CO2 + CoA; Xref=Rhea:RHEA:33683, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:65073; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33684; Evidence=; Reaction=H(+) + L-serine + tetradecanoyl-CoA = 3-oxohexadecasphinganine + CO2 + CoA; Xref=Rhea:RHEA:35675, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:71007; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35676; Evidence=; Reaction=dodecanoyl-CoA + H(+) + L-serine = 3-oxotetradecasphinganine + CO2 + CoA; Xref=Rhea:RHEA:35679, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:71008; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35680; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; SPT complex catalytic activity is negatively regulated by ORMDL proteins, including ORMDL3, in the presence of ceramides (By similarity). This mechanism allows to maintain ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (Probable). Lipid metabolism; sphingolipid metabolism. Component of the serine palmitoyltransferase (SPT) complex, which is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB (By similarity). The heterodimer with SPTLC2 or SPTLC3 forms the catalytic core of the enzyme, while SPTSSA or SPTSSB subunits determine substrate specificity (By similarity). SPT also interacts with ORMDL proteins, especially ORMDL3, which negatively regulate SPT activity in the presence of ceramides (By similarity). Forms dimers of heterodimers with SPTLC2 (By similarity). Interacts with RTN4 (isoform B) (PubMed:26301690). Endoplasmic reticulum membrane ; Single-pass membrane protein Expressed in a variety of tissues. Highest expression in brain, kidney and liver (PubMed:21994399). Expressed in brown and white adipose tissues (PubMed:27818258). Highly expressed after birth, expression decreases 2 weeks after birth and is maintained until, at least, 18 months. Expression levels at protein level increase upon high-fat diet. mRNA levels remain unchanged. The transmembrane domain is involved in the interaction with ORMDL3. Phosphorylation at Tyr-164 inhibits activity and promotes cell survival. Knockout are lethal at embryonic stage (PubMed:28100772). Conditional knockouts specific to the adipose tissue develop adipose tissue but exhibit a striking age dependent loss of adipose tissue accompanied by evidence of adipocyte death, increased macrophage infiltration and tissue fibrosis. They also have elevated fasting blood glucose, fatty liver and insulin resistance. They show a significant reduction of total sphingomyelin levels in the adipose tissue (PubMed:28100772). Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. catalytic activity serine C-palmitoyltransferase activity protein binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process sphingolipid metabolic process sphingomyelin biosynthetic process biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups serine C-palmitoyltransferase complex sphingolipid biosynthetic process pyridoxal phosphate binding SPOTS complex sphinganine biosynthetic process sphingosine biosynthetic process ceramide biosynthetic process positive regulation of lipophagy regulation of fat cell apoptotic process uc007qnk.1 uc007qnk.2 uc007qnk.3 uc007qnk.4 
ENSMUST00000021921.11 Ptch1 ENSMUST00000021921.11 patched 1, transcript variant 1 (from RefSeq NM_008957.3) ENSMUST00000021921.1 ENSMUST00000021921.10 ENSMUST00000021921.2 ENSMUST00000021921.3 ENSMUST00000021921.4 ENSMUST00000021921.5 ENSMUST00000021921.6 ENSMUST00000021921.7 ENSMUST00000021921.8 ENSMUST00000021921.9 NM_008957 PTC1_MOUSE Ptch Q61115 uc007qxv.1 uc007qxv.2 uc007qxv.3 Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. Interacts with SNX17 (By similarity). Interacts with IHH (PubMed:21537345). Interacts with G-protein coupled receptor GPR37L1 (PubMed:24062445). Q61115; Q96EY1: DNAJA3; Xeno; NbExp=2; IntAct=EBI-15619523, EBI-356767; Cell membrane ; Multi-pass membrane protein Detected in cerebellar Bergmann glia cells (at protein level) (PubMed:24062445). In the developing embryo, first detected within the ventral neural tube and later in the somites and limb buds (PubMed:8595881). Expression in the limb buds is restricted to the posterior ectoderm surrounding the zone of polarizing activity (PubMed:8595881). In the adult, expression is seen in brain, lung, liver, kidney and ocular tissues; lower levels in heart, skeletal muscle, and testis (PubMed:8595881). Expressed at very low levels at 7 dpc, is most strongly expressed between 11 and 15 dpc, and persists at moderate levels at 17 dpc (PubMed:8595881). Also expressed in the adult (PubMed:8595881). Activated by Sonic hedgehog. Glycosylation is necessary for SHH binding. In the absence of Hh ligands, ubiquitination by ITCH at Lys-1413 promotes endocytosis and both proteasomal and lysosomal degradation. Belongs to the patched family. negative regulation of transcription from RNA polymerase II promoter branching involved in ureteric bud morphogenesis in utero embryonic development cell fate determination neural tube formation neural tube closure heart morphogenesis patched binding smoothened binding protein binding extracellular region nucleus Golgi apparatus plasma membrane integral component of plasma membrane caveola cilium signal transduction smoothened signaling pathway regulation of mitotic cell cycle pattern specification process brain development hedgehog receptor activity heparin binding zinc ion binding negative regulation of cell proliferation epidermis development response to mechanical stimulus animal organ morphogenesis dorsal/ventral pattern formation epidermal cell fate specification response to chlorate positive regulation of cholesterol efflux postsynaptic density response to organic cyclic compound cholesterol binding membrane integral component of membrane protein processing spinal cord motor neuron differentiation neural tube patterning dorsal/ventral neural tube patterning neural plate axis specification embryonic limb morphogenesis cyclin binding midbody prostate gland development mammary gland development response to estradiol response to retinoic acid regulation of protein localization limb morphogenesis hindlimb morphogenesis regulation of growth negative regulation of multicellular organism growth regulation of cell proliferation response to drug glucose homeostasis intracellular membrane-bounded organelle negative regulation of sequence-specific DNA binding transcription factor activity keratinocyte proliferation dendritic growth cone axonal growth cone macromolecular complex binding positive regulation of epidermal cell differentiation negative regulation of osteoblast differentiation negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated perinuclear region of cytoplasm embryonic organ development negative regulation of epithelial cell proliferation negative regulation of cell division pharyngeal system development mammary gland duct morphogenesis mammary gland epithelial cell differentiation smoothened signaling pathway involved in dorsal/ventral neural tube patterning cell differentiation involved in kidney development somite development cellular response to cholesterol commissural neuron axon guidance renal system development cell proliferation involved in metanephros development protein localization to plasma membrane hedgehog family protein binding liver regeneration uc007qxv.1 uc007qxv.2 uc007qxv.3 
ENSMUST00000021922.10 Msx2 ENSMUST00000021922.10 msh homeobox 2 (from RefSeq NM_013601.2) ENSMUST00000021922.1 ENSMUST00000021922.2 ENSMUST00000021922.3 ENSMUST00000021922.4 ENSMUST00000021922.5 ENSMUST00000021922.6 ENSMUST00000021922.7 ENSMUST00000021922.8 ENSMUST00000021922.9 Msx2 NM_013601 Q3UZH5 Q3UZH5_MOUSE uc007qnw.1 uc007qnw.2 uc007qnw.3 Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. Nucleus Belongs to the Msh homeobox family. negative regulation of transcription from RNA polymerase II promoter DNA binding nucleus cytosol regulation of transcription, DNA-templated nuclear speck sequence-specific DNA binding uc007qnw.1 uc007qnw.2 uc007qnw.3 
ENSMUST00000021929.10 Habp4 ENSMUST00000021929.10 hyaluronic acid binding protein 4 (from RefSeq NM_019986.3) E9QKB2 E9QKB2_MOUSE ENSMUST00000021929.1 ENSMUST00000021929.2 ENSMUST00000021929.3 ENSMUST00000021929.4 ENSMUST00000021929.5 ENSMUST00000021929.6 ENSMUST00000021929.7 ENSMUST00000021929.8 ENSMUST00000021929.9 Habp4 NM_019986 uc011zaz.1 uc011zaz.2 uc011zaz.3 Cytoplasm, Stress granule Nucleus speckle Nucleus, Cajal body Nucleus, nucleolus Belongs to the SERBP1-HABP4 family. RNA binding nucleus nucleolus cytoplasm cytoplasmic stress granule Cajal body nuclear speck sarcomere PML body organization SUMO binding positive regulation of RNA splicing negative regulation of DNA binding positive regulation of translational initiation cellular response to mechanical stimulus Gemini of coiled bodies uc011zaz.1 uc011zaz.2 uc011zaz.3 
ENSMUST00000021930.10 Sfxn1 ENSMUST00000021930.10 sideroflexin 1 (from RefSeq NM_027324.5) ENSMUST00000021930.1 ENSMUST00000021930.2 ENSMUST00000021930.3 ENSMUST00000021930.4 ENSMUST00000021930.5 ENSMUST00000021930.6 ENSMUST00000021930.7 ENSMUST00000021930.8 ENSMUST00000021930.9 NM_027324 Q3UB44 Q99JR1 Q9CZG4 SFXN1_MOUSE Sfxn1 uc007qoa.1 uc007qoa.2 uc007qoa.3 uc007qoa.4 uc007qoa.5 Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine. Reaction=L-serine(in) = L-serine(out); Xref=Rhea:RHEA:35031, ChEBI:CHEBI:33384; Evidence=; Reaction=L-alanine(in) = L-alanine(out); Xref=Rhea:RHEA:70719, ChEBI:CHEBI:57972; Evidence=; Reaction=L-cysteine(in) = L-cysteine(out); Xref=Rhea:RHEA:29655, ChEBI:CHEBI:35235; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Widely expressed, with highest expression in kidney and liver. Very high levels in the liver during the period of embryonic hepatic hemopoiesis. Defects in Sfxn1 are the cause of a transitory hypochromic, microcytic anemia characterized by a large number of siderocytes containing non-heme iron granules (PubMed:11274051). The anemia begins at 12 dpc, is most intense at 15 dpc and is still severe at birth, but disappears by 2 weeks of age (PubMed:11274051). Mutant adults are no longer anemic, but they have an impaired response to hemopoietic stress (PubMed:11274051). Most homozygotes also have flexed tails and a belly spot (PubMed:11274051). Belongs to the sideroflexin family. Sequence=AK012650; Type=Frameshift; Evidence=; mitochondrion mitochondrial inner membrane one-carbon metabolic process ion transport iron ion transport amino acid transport ion transmembrane transporter activity L-serine transmembrane transporter activity L-serine transport membrane integral component of membrane erythrocyte differentiation integral component of mitochondrial inner membrane D-serine transport D-serine transmembrane transporter activity transmembrane transport uc007qoa.1 uc007qoa.2 uc007qoa.3 uc007qoa.4 uc007qoa.5 
ENSMUST00000021932.6 Drd1 ENSMUST00000021932.6 dopamine receptor D1, transcript variant 1 (from RefSeq NM_010076.3) B2RPW8 DRD1_MOUSE Drd1a ENSMUST00000021932.1 ENSMUST00000021932.2 ENSMUST00000021932.3 ENSMUST00000021932.4 ENSMUST00000021932.5 Gpcr15 NM_010076 Q61616 Q8C8P8 uc033glr.1 uc033glr.2 uc033glr.3 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD2 (PubMed:25865831). Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Cell projection, cilium membrane ; Multi-pass membrane protein Cell projection, dendrite Cell projection, dendritic spine Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. Belongs to the G-protein coupled receptor 1 family. dopamine neurotransmitter receptor activity, coupled via Gs temperature homeostasis conditioned taste aversion behavioral fear response regulation of protein phosphorylation positive regulation of protein phosphorylation synaptic transmission, dopaminergic G-protein alpha-subunit binding response to amphetamine G-protein coupled receptor activity adrenergic receptor activity dopamine neurotransmitter receptor activity receptor binding protein binding nucleus endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane caveola cilium negative regulation of protein kinase activity protein import into nucleus intracellular protein transport muscle contraction signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity adenylate cyclase-activating dopamine receptor signaling pathway dopamine receptor signaling pathway learning memory mating behavior grooming behavior locomotory behavior adult walking behavior feeding behavior drug binding associative learning visual learning positive regulation of gene expression endomembrane system astrocyte development dopamine transport membrane integral component of membrane transmission of nerve impulse neuronal action potential regulation of vasoconstriction calcium-mediated signaling protein phosphatase binding dentate gyrus development striatum development hippocampus development cerebral cortex GABAergic interneuron migration positive regulation of cell migration negative regulation of cell migration axon dendrite peristalsis angiotensin receptor binding D3 dopamine receptor binding operant conditioning social behavior dopamine binding regulation of dopamine metabolic process response to cocaine vasodilation negative regulation of circadian sleep/wake cycle, sleep response to drug maternal behavior eating behavior cell projection neuronal cell body dendritic spine dendritic shaft regulation of ion transport axon terminus histone H3-S10 phosphorylation dendritic spine neck dendritic spine head macromolecular complex binding positive regulation of membrane potential glucose import habituation sensitization protein heterodimerization activity behavioral response to cocaine regulation of long-term neuronal synaptic plasticity ATPase binding positive regulation of release of sequestered calcium ion into cytosol positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway positive regulation of synaptic transmission, glutamatergic phospholipase C-activating dopamine receptor signaling pathway ciliary membrane long-term synaptic potentiation long term synaptic depression negative regulation of cell death cellular response to catecholamine stimulus adenylate cyclase-activating adrenergic receptor signaling pathway non-motile cilium glutamatergic synapse GABA-ergic synapse modification of postsynaptic structure integral component of postsynaptic membrane integral component of presynaptic membrane positive regulation of long-term synaptic potentiation cellular response to dopamine positive regulation of feeding behavior regulation of synaptic vesicle exocytosis startle response prepulse inhibition uc033glr.1 uc033glr.2 uc033glr.3 
ENSMUST00000021937.12 Zfp346 ENSMUST00000021937.12 zinc finger protein 346, transcript variant 1 (from RefSeq NM_012017.2) ENSMUST00000021937.1 ENSMUST00000021937.10 ENSMUST00000021937.11 ENSMUST00000021937.2 ENSMUST00000021937.3 ENSMUST00000021937.4 ENSMUST00000021937.5 ENSMUST00000021937.6 ENSMUST00000021937.7 ENSMUST00000021937.8 ENSMUST00000021937.9 Jaz NM_012017 Q9R0B7 ZN346_MOUSE Znf346 uc007qpy.1 uc007qpy.2 uc007qpy.3 Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (By similarity) (PubMed:10488071). May bind to specific miRNA hairpins (By similarity). Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner (By similarity). Nucleus, nucleolus Cytoplasm Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5 (By similarity). Expressed in all tissues tested, including heart, brain, spleen, lung, liver, muscle, kidney and testis. Exogenous expression induced apoptosis. The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization. nucleic acid binding RNA binding double-stranded RNA binding protein binding nucleus nucleolus cytoplasm zinc ion binding enzyme binding miRNA binding positive regulation of apoptotic process metal ion binding uc007qpy.1 uc007qpy.2 uc007qpy.3 
ENSMUST00000021939.8 Cdk20 ENSMUST00000021939.8 cyclin dependent kinase 20 (from RefSeq NM_053180.2) CDK20_MOUSE Ccrk Cdch ENSMUST00000021939.1 ENSMUST00000021939.2 ENSMUST00000021939.3 ENSMUST00000021939.4 ENSMUST00000021939.5 ENSMUST00000021939.6 ENSMUST00000021939.7 NM_053180 Q5EDC2 Q9JHU3 uc007qyx.1 uc007qyx.2 uc007qyx.3 Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Monomer (By similarity). Interacts with MAK (By similarity). Interacts with TBC1D32. Nucleus Cytoplasm Cell projection, cilium Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JHU3-1; Sequence=Displayed; Name=2; Synonyms=Cardiac CCRK; IsoId=Q9JHU3-2; Sequence=VSP_016753, VSP_016754; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cilium protein phosphorylation cell cycle multicellular organism development kinase activity phosphorylation transferase activity cell projection cell division regulation of cell cycle uc007qyx.1 uc007qyx.2 uc007qyx.3 
ENSMUST00000021940.8 Lman2 ENSMUST00000021940.8 lectin, mannose-binding 2 (from RefSeq NM_025828.3) ENSMUST00000021940.1 ENSMUST00000021940.2 ENSMUST00000021940.3 ENSMUST00000021940.4 ENSMUST00000021940.5 ENSMUST00000021940.6 ENSMUST00000021940.7 LMAN2_MOUSE NM_025828 Q8BJL4 Q9CXG7 Q9DBH5 uc007qqo.1 uc007qqo.2 Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high- mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 calcium ions per subunit. ; Golgi apparatus membrane ; Single- pass type I membrane protein Golgi membrane mannose binding extracellular space endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus integral component of plasma membrane ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER endoplasmic reticulum organization Golgi organization cell surface protein transport membrane integral component of membrane ER to Golgi transport vesicle carbohydrate binding heat shock protein binding metal ion binding positive regulation of phagocytosis uc007qqo.1 uc007qqo.2 
ENSMUST00000021941.8 Mxd3 ENSMUST00000021941.8 Max dimerization protein 3 (from RefSeq NM_016662.5) ENSMUST00000021941.1 ENSMUST00000021941.2 ENSMUST00000021941.3 ENSMUST00000021941.4 ENSMUST00000021941.5 ENSMUST00000021941.6 ENSMUST00000021941.7 MAD3_MOUSE Mad3 NM_016662 Q60947 Q80US8 uc007qqn.1 uc007qqn.2 uc007qqn.3 Transcriptional repressor. Binds with MAX to form a sequence- specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17. Nucleus Expressed only in the proliferating areas of the testis and thymus. Expressed during neural and epidermal differentiation. Expression restricted to proliferating cells prior to differentiation. Specifically expressed in the S phase of the cell cycle in neuronal progenitor cells. In the developing embryo, detected from 9.5 to 12.5 dpc especially in the ventricular zone of the neuroepithelia, in the progression zone of the limb buds and in the aortic arches and liver. In the spinal cord at embryonic days 10.5, 11.5 and 12.5 dpc, expressed in the cells at the perimeter of the ventricular zone. In the developing epidermis, expressed only in the uppermost differentiated cell layers underneath the stratum corneum. Mice deficient for Mxd3 show increased sensitivity of neuronal and lymphoid cells to gamma-radiation induced apoptosis. negative regulation of transcription from RNA polymerase II promoter DNA binding protein binding nucleus negative regulation of transcription, DNA-templated protein dimerization activity RNA polymerase II transcription factor complex RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding uc007qqn.1 uc007qqn.2 uc007qqn.3 
ENSMUST00000021942.8 Prelid1 ENSMUST00000021942.8 PRELI domain containing 1 (from RefSeq NM_025596.5) ENSMUST00000021942.1 ENSMUST00000021942.2 ENSMUST00000021942.3 ENSMUST00000021942.4 ENSMUST00000021942.5 ENSMUST00000021942.6 ENSMUST00000021942.7 NM_025596 PRLD1_MOUSE Preli Q3UCN0 Q4QQJ9 Q6PCZ5 Q78IE2 Q8R107 Q9D1F7 uc007qql.1 uc007qql.2 uc007qql.3 Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4- induced Th2 cell number. May be important for the development of vital and immunocompetent organs (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn- glycero-3-phosphate(out); Xref=Rhea:RHEA:36435, ChEBI:CHEBI:58608; Evidence=; Forms a complex with TRIAP1 in the mitochondrion intermembrane space. Interacts with OPA1 and AIFM1 (By similarity). Mitochondrion Mitochondrion intermembrane space Abundantly expressed in all tissues tested except testis with highest levels in thymus. nucleoplasm mitochondrion mitochondrial intermembrane space lipid transport apoptotic process negative regulation of mitochondrial membrane potential positive regulation of endopeptidase activity phospholipid transport macromolecular complex negative regulation of apoptotic process regulation of T cell differentiation regulation of mitochondrial membrane potential positive regulation of T cell apoptotic process negative regulation of release of cytochrome c from mitochondria regulation of membrane lipid distribution positive regulation of cellular respiration phosphatidic acid transporter activity positive regulation of phospholipid transport uc007qql.1 uc007qql.2 uc007qql.3 
ENSMUST00000021948.15 F12 ENSMUST00000021948.15 coagulation factor XII (Hageman factor) (from RefSeq NM_021489.3) ENSMUST00000021948.1 ENSMUST00000021948.10 ENSMUST00000021948.11 ENSMUST00000021948.12 ENSMUST00000021948.13 ENSMUST00000021948.14 ENSMUST00000021948.2 ENSMUST00000021948.3 ENSMUST00000021948.4 ENSMUST00000021948.5 ENSMUST00000021948.6 ENSMUST00000021948.7 ENSMUST00000021948.8 ENSMUST00000021948.9 FA12_MOUSE NM_021489 O35727 Q6PER0 Q80YC5 uc007qqv.1 uc007qqv.2 uc007qqv.3 uc007qqv.4 uc007qqv.5 This gene encodes a glycoprotein coagulation factor that plays an important role in the intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that is autoactivated upon contact with negatively charged surfaces or misfolded protein aggregates. Mice lacking the encoded protein have a severe defect in forming stable fibrin clots. [provided by RefSeq, Apr 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC037085.1, BC057921.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). Reaction=Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.; EC=3.4.21.38; Interacts with HRG; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding, inhibits factor XII autoactivation and contact-initiated coagulation. Secreted O- and N-glycosylated. Belongs to the peptidase S1 family. Sequence=AAH49867.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; plasma kallikrein-kinin cascade Factor XII activation serine-type endopeptidase activity calcium ion binding extracellular region extracellular space rough endoplasmic reticulum proteolysis blood coagulation hemostasis peptidase activity serine-type peptidase activity positive regulation of plasminogen activation protein processing protein autoprocessing hydrolase activity positive regulation of blood coagulation zymogen activation fibrinolysis response to misfolded protein positive regulation of fibrinolysis uc007qqv.1 uc007qqv.2 uc007qqv.3 uc007qqv.4 uc007qqv.5 
ENSMUST00000021956.9 Ddx41 ENSMUST00000021956.9 DEAD box helicase 41 (from RefSeq NM_134059.2) DDX41_MOUSE ENSMUST00000021956.1 ENSMUST00000021956.2 ENSMUST00000021956.3 ENSMUST00000021956.4 ENSMUST00000021956.5 ENSMUST00000021956.6 ENSMUST00000021956.7 ENSMUST00000021956.8 NM_134059 Q3U0E0 Q91VN6 uc007qro.1 uc007qro.2 uc007qro.3 Probable ATP-dependent RNA helicase. Is required during post- transcriptional gene expression. May be involved in pre-mRNA splicing. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Identified in the spliceosome C complex (By similarity). Interacts with ERCC6 (By similarity). Interacts with FAM50A (By similarity). Q91VN6; Q3TBT3: Sting1; NbExp=4; IntAct=EBI-2551902, EBI-3862093; Q91VN6; Q62191: Trim21; NbExp=6; IntAct=EBI-2551902, EBI-6840982; Nucleus Belongs to the DEAD box helicase family. DDX41 subfamily. nucleotide binding mRNA splicing, via spliceosome nucleic acid binding DNA binding RNA binding RNA helicase activity helicase activity protein binding ATP binding nucleus spliceosomal complex endoplasmic reticulum mRNA processing cell proliferation RNA splicing hydrolase activity cell differentiation cellular response to interferon-beta positive regulation of transcription from RNA polymerase II promoter metal ion binding defense response to virus catalytic step 2 spliceosome uc007qro.1 uc007qro.2 uc007qro.3 
ENSMUST00000021957.8 Fam193b ENSMUST00000021957.8 family with sequence similarity 193, member B, transcript variant 1 (from RefSeq NM_145382.5) ENSMUST00000021957.1 ENSMUST00000021957.2 ENSMUST00000021957.3 ENSMUST00000021957.4 ENSMUST00000021957.5 ENSMUST00000021957.6 ENSMUST00000021957.7 F193B_MOUSE Kiaa1931 NM_145382 Q3U2K0 Q69Z63 Q8K1B4 Q8VCA1 uc011yzv.1 uc011yzv.2 Cytoplasm Nucleus Note=Partly colocalized with an endoplasmic reticulum marker, HSP90B1. Shuttles between nucleus and cytoplasm (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U2K0-1; Sequence=Displayed; Name=2; IsoId=Q3U2K0-2; Sequence=VSP_034782; Name=3; IsoId=Q3U2K0-3; Sequence=VSP_034781; Belongs to the FAM193 family. Sequence=AAH25483.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAD32581.1; Type=Erroneous initiation; Evidence=; molecular_function nucleus nucleoplasm cytoplasm biological_process uc011yzv.1 uc011yzv.2 
ENSMUST00000021959.11 Txndc15 ENSMUST00000021959.11 thioredoxin domain containing 15 (from RefSeq NM_175150.3) ENSMUST00000021959.1 ENSMUST00000021959.10 ENSMUST00000021959.2 ENSMUST00000021959.3 ENSMUST00000021959.4 ENSMUST00000021959.5 ENSMUST00000021959.6 ENSMUST00000021959.7 ENSMUST00000021959.8 ENSMUST00000021959.9 NM_175150 Q52KM6 Q6P6J9 Q8BV80 Q8K319 TXD15_MOUSE uc007qry.1 uc007qry.2 uc007qry.3 uc007qry.4 Acts as a positive regulator of ciliary hedgehog signaling (PubMed:29459677). Required for cilia biogenesis (PubMed:29459677). Cell projection, cilium membrane ; Single-pass type I membrane protein Sequence=BAC37669.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component cell biological_process membrane integral component of membrane cell redox homeostasis uc007qry.1 uc007qry.2 uc007qry.3 uc007qry.4 
ENSMUST00000021961.12 Catsper3 ENSMUST00000021961.12 cation channel, sperm associated 3, transcript variant 1 (from RefSeq NM_001252487.1) CTSR3_MOUSE ENSMUST00000021961.1 ENSMUST00000021961.10 ENSMUST00000021961.11 ENSMUST00000021961.2 ENSMUST00000021961.3 ENSMUST00000021961.4 ENSMUST00000021961.5 ENSMUST00000021961.6 ENSMUST00000021961.7 ENSMUST00000021961.8 ENSMUST00000021961.9 NM_001252487 Q5FWA9 Q80W99 Q9D5T9 uc007qsc.1 uc007qsc.2 uc007qsc.3 uc007qsc.4 Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. In contrast to the human ortholog, not activated by progesterone. Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG2, CATSPERD, CATSPERE, CATSPERZ, C2CD6/CATSPERT, SLCO6C1, TMEM249, TMEM262 and EFCAB9 (PubMed:34225353, PubMed:17227845, PubMed:21224844, PubMed:34998468). HSPA1 may be an additional auxiliary complex member (By similarity). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (PubMed:34225353). The auxiliary CATSPERB, CATSPERG2, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively (PubMed:34225353). SLCO6C1 interacts with CATSPERE and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex (PubMed:34225353). C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane (PubMed:34998468). Q80W99; Q91ZR5: Catsper1; NbExp=2; IntAct=EBI-15619135, EBI-15619083; Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80W99-1; Sequence=Displayed; Name=2; IsoId=Q80W99-2; Sequence=VSP_026978; Testis-specific. Detected in hte testis during postnatal development at day 15. Restricted to the late-stage germline cells that line the seminiferous tubules. Mice are normal but males are sterile. Male sterility is due to defects in sperm motility unability to fertilize intact eggs. Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. Sequence=AAH89518.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence=; acrosomal vesicle ion channel activity voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity protein binding endoplasmic reticulum plasma membrane cilium ion transport sodium ion transport calcium ion transport multicellular organism development spermatogenesis membrane integral component of membrane cell differentiation flagellated sperm motility motile cilium regulation of ion transmembrane transport CatSper complex cell projection sperm capacitation transmembrane transport calcium ion transmembrane transport uc007qsc.1 uc007qsc.2 uc007qsc.3 uc007qsc.4 
ENSMUST00000021963.5 Caml ENSMUST00000021963.5 calcium modulating ligand (from RefSeq NM_007596.2) CAMLG_MOUSE Caml Camlg ENSMUST00000021963.1 ENSMUST00000021963.2 ENSMUST00000021963.3 ENSMUST00000021963.4 Get2 NM_007596 P49070 Q99JU5 uc007qrv.1 uc007qrv.2 uc007qrv.3 Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (By similarity). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (By similarity). Required for the stability of GET1 (By similarity). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (By similarity). Essential for the survival of peripheral follicular B cells (PubMed:22351938). Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40 (By similarity). Within the complex, GET1 and CAMLG form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (By similarity). Interacts (via C-terminus) with GET1 (By similarity). Interacts (via N-terminus) with GET3 (By similarity). GET3 shows a higher affinity for CAMLG than for GET1 (By similarity). Interacts (via N-terminus) with TNFRSF13B/TACI (via C-terminus) (By similarity). P49070; E9PZQ0: Ryr1; NbExp=3; IntAct=EBI-309114, EBI-642079; Endoplasmic reticulum membrane ; Multi-pass membrane protein Conditional knockout in B cells results in significant reduction in the number of mature follicular B cells with normal cellular proliferation but increased cellular turnover. receptor recycling protein binding cytoplasm endoplasmic reticulum epidermal growth factor receptor signaling pathway membrane integral component of membrane negative regulation of protein ubiquitination ubiquitin protein ligase binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process protein stabilization cell adhesion molecule binding uc007qrv.1 uc007qrv.2 uc007qrv.3 
ENSMUST00000021968.7 Pitx1 ENSMUST00000021968.7 paired-like homeodomain transcription factor 1 (from RefSeq NM_011097.2) ENSMUST00000021968.1 ENSMUST00000021968.2 ENSMUST00000021968.3 ENSMUST00000021968.4 ENSMUST00000021968.5 ENSMUST00000021968.6 NM_011097 Pitx1 Q3UQH0 Q3UQH0_MOUSE uc007qsd.1 uc007qsd.2 uc007qsd.3 Nucleus Belongs to the paired homeobox family. Bicoid subfamily. RNA polymerase II transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleolus regulation of transcription, DNA-templated multicellular organism development sequence-specific DNA binding uc007qsd.1 uc007qsd.2 uc007qsd.3 
ENSMUST00000021970.11 Cxcl14 ENSMUST00000021970.11 C-X-C motif chemokine ligand 14 (from RefSeq NM_019568.2) Bmac CXL14_MOUSE ENSMUST00000021970.1 ENSMUST00000021970.10 ENSMUST00000021970.2 ENSMUST00000021970.3 ENSMUST00000021970.4 ENSMUST00000021970.5 ENSMUST00000021970.6 ENSMUST00000021970.7 ENSMUST00000021970.8 ENSMUST00000021970.9 Kec Ks1 Mip2g NM_019568 Q548T5 Q91V02 Q9JHH7 Q9WUQ5 Scyb14 uc007qsm.1 uc007qsm.2 uc007qsm.3 Chemotactic for CESS B-cells and THP-1 monocytes, but not T- cells. Secreted Highly expressed in brain, lung, ovary, muscle and in kidney and liver parenchyma, and at lower levels in bone marrow. The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway. Ubiquitinated, followed by degradation by the proteasome. Belongs to the intercrine alpha (chemokine CxC) family. cytokine activity extracellular region extracellular space Golgi apparatus immune response signal transduction chemokine activity killing of cells of other organism negative regulation of myoblast differentiation inner ear development cell chemotaxis positive regulation of natural killer cell chemotaxis uc007qsm.1 uc007qsm.2 uc007qsm.3 
ENSMUST00000021971.6 Slc25a48 ENSMUST00000021971.6 solute carrier family 25, member 48 (from RefSeq NM_177809.4) ENSMUST00000021971.1 ENSMUST00000021971.2 ENSMUST00000021971.3 ENSMUST00000021971.4 ENSMUST00000021971.5 NM_177809 Q3KNJ4 Q8BW66 S2548_MOUSE uc007qsn.1 uc007qsn.2 uc007qsn.3 uc007qsn.4 Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. mitochondrion mitochondrial inner membrane acyl carnitine transport acyl carnitine transmembrane transporter activity membrane integral component of membrane acyl carnitine transmembrane transport uc007qsn.1 uc007qsn.2 uc007qsn.3 uc007qsn.4 
ENSMUST00000021990.4 Ptdss1 ENSMUST00000021990.4 phosphatidylserine synthase 1 (from RefSeq NM_008959.3) ENSMUST00000021990.1 ENSMUST00000021990.2 ENSMUST00000021990.3 NM_008959 O55024 PTSS1_MOUSE Pssa Q3UV14 Q8C2S8 Q99LH2 uc007qzz.1 uc007qzz.2 Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:10432300, PubMed:9516423, PubMed:18343815, PubMed:10938271). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:9516423, PubMed:18343815, PubMed:10432300, PubMed:10938271). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:10432300, PubMed:9516423, PubMed:18343815, PubMed:10938271). Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine; Xref=Rhea:RHEA:27606, ChEBI:CHEBI:33384, ChEBI:CHEBI:57262, ChEBI:CHEBI:57603, ChEBI:CHEBI:64612; EC=2.7.8.29; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27607; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2- diacyl-sn-glycero-3-phospho-L-serine + choline; Xref=Rhea:RHEA:45088, ChEBI:CHEBI:15354, ChEBI:CHEBI:33384, ChEBI:CHEBI:57262, ChEBI:CHEBI:57643; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45089; Evidence=; Potently inhibited by choline in the mitochondria- associated membrane (MAM). Very little inhibition by choline in the endoplasmic reticulum (ER) per se. Phospholipid metabolism; phosphatidylserine biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Highly enriched in the mitochondria-associated membrane (MAM). Expressed in kidney, testis, lung, skeletal muscle, liver brain, heart and spleen with highest expression in testis, liver, heart and brain. Null mice are viable, fertile and have a normal life span. Toal serine exchange is reduced up to 85%, but apart from in liver, the phosphatatidylserine content was unaltered. Elimination of either Pss1 or Pss2, but not both, is compatible with mouse viability. Mice can tolerate as little as 10% serine-exchange activity and are viable with small amounts of phosphatidylserine and phosphatidylethanolamine content. to phosphatidylethanolamine. Belongs to the phosphatidyl serine synthase family. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phosphatidylserine biosynthetic process phospholipid biosynthetic process membrane integral component of membrane transferase activity uc007qzz.1 uc007qzz.2 
ENSMUST00000021991.11 Mterf3 ENSMUST00000021991.11 mitochondrial transcription termination factor 3 (from RefSeq NM_025547.4) CGI-12 ENSMUST00000021991.1 ENSMUST00000021991.10 ENSMUST00000021991.2 ENSMUST00000021991.3 ENSMUST00000021991.4 ENSMUST00000021991.5 ENSMUST00000021991.6 ENSMUST00000021991.7 ENSMUST00000021991.8 ENSMUST00000021991.9 MTEF3_MOUSE Mterfd1 NM_025547 Q8R3J4 Q9CSV1 Q9CWM7 uc007qzw.1 uc007qzw.2 uc007qzw.3 uc007qzw.4 uc007qzw.5 Binds promoter DNA and regulates initiation of transcription (By similarity). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes (PubMed:17662942, PubMed:23300484). Required for normal mitochondrial function (PubMed:17662942, PubMed:23300484). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (PubMed:17662942, PubMed:23300484). Mitochondrion Contains seven structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a superhelical structure with a solenoid shape. Embryonic lethality, due to severe mitochondrial dysfunction. Embryos are much smaller than normal and none survive past 10.5 dpc. Belongs to the mTERF family. DNA binding double-stranded DNA binding nucleoplasm mitochondrion regulation of transcription, DNA-templated transcription from mitochondrial promoter mitochondrial translation ribosome biogenesis transcription regulatory region DNA binding negative regulation of transcription, DNA-templated mitochondrial ribosome assembly uc007qzw.1 uc007qzw.2 uc007qzw.3 uc007qzw.4 uc007qzw.5 
ENSMUST00000021993.5 Uqcrb ENSMUST00000021993.5 ubiquinol-cytochrome c reductase binding protein (from RefSeq NM_026219.2) ENSMUST00000021993.1 ENSMUST00000021993.2 ENSMUST00000021993.3 ENSMUST00000021993.4 NM_026219 Q9CQB4 Q9CQB4_MOUSE Uqcrb uc007qzu.1 uc007qzu.2 uc007qzu.3 Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. Mitochondrion inner membrane Belongs to the UQCRB/QCR7 family. mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex III mitochondrial electron transport, ubiquinol to cytochrome c membrane oxidation-reduction process respiratory chain uc007qzu.1 uc007qzu.2 uc007qzu.3 
ENSMUST00000021997.8 Rsl1 ENSMUST00000021997.8 Nucleus (from UniProt Q7M6Y1) BC103788 ENSMUST00000021997.1 ENSMUST00000021997.2 ENSMUST00000021997.3 ENSMUST00000021997.4 ENSMUST00000021997.5 ENSMUST00000021997.6 ENSMUST00000021997.7 Q7M6Y1 Q7M6Y1_MOUSE Rsl1 uc007rai.1 uc007rai.2 uc007rai.3 uc007rai.4 Nucleus negative regulation of transcription from RNA polymerase II promoter nucleic acid binding cellular_component regulation of transcription, DNA-templated sex determination enhancer binding sequence-specific DNA binding regulation of DNA methylation negative regulation of transcription, DNA-templated metal ion binding uc007rai.1 uc007rai.2 uc007rai.3 uc007rai.4 
ENSMUST00000022007.8 Cfap90 ENSMUST00000022007.8 cilia and flagella associated protein 90 (from RefSeq NM_027035.1) CFA90_MOUSE ENSMUST00000022007.1 ENSMUST00000022007.2 ENSMUST00000022007.3 ENSMUST00000022007.4 ENSMUST00000022007.5 ENSMUST00000022007.6 ENSMUST00000022007.7 NM_027035 Q9DAR0 uc007rcd.1 uc007rcd.2 uc007rcd.3 uc007rcd.4 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Cytoplasm, cytoskeleton, cilium axoneme Expressed in sperm (at protein level). On the 2D-gel the determined pI of this protein is: 7.7, its MW is: 22 kDa. molecular_function cellular_component biological_process uc007rcd.1 uc007rcd.2 uc007rcd.3 uc007rcd.4 
ENSMUST00000022009.10 Cetn3 ENSMUST00000022009.10 centrin 3 (from RefSeq NM_007684.4) Cetn3 ENSMUST00000022009.1 ENSMUST00000022009.2 ENSMUST00000022009.3 ENSMUST00000022009.4 ENSMUST00000022009.5 ENSMUST00000022009.6 ENSMUST00000022009.7 ENSMUST00000022009.8 ENSMUST00000022009.9 NM_007684 Q545L8 Q545L8_MOUSE uc007rid.1 uc007rid.2 uc007rid.3 calcium ion binding centrosome uc007rid.1 uc007rid.2 uc007rid.3 
ENSMUST00000022013.8 Adcy2 ENSMUST00000022013.8 adenylate cyclase 2 (from RefSeq NM_153534.2) Adcy2 ENSMUST00000022013.1 ENSMUST00000022013.2 ENSMUST00000022013.3 ENSMUST00000022013.4 ENSMUST00000022013.5 ENSMUST00000022013.6 ENSMUST00000022013.7 NM_153534 Q3V1Q3 Q3V1Q3_MOUSE uc007rcf.1 uc007rcf.2 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro). ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding adenylate cyclase activity ATP binding cytoplasm plasma membrane cAMP biosynthetic process cyclic nucleotide biosynthetic process membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity intracellular signal transduction metal ion binding uc007rcf.1 uc007rcf.2 
ENSMUST00000022019.4 Il9 ENSMUST00000022019.4 interleukin 9 (from RefSeq NM_008373.2) ENSMUST00000022019.1 ENSMUST00000022019.2 ENSMUST00000022019.3 IL9_MOUSE NM_008373 P15247 uc007qso.1 uc007qso.2 Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:11070175, PubMed:19433802). Affects intestinal epithelial permeability and adaptive immunity (PubMed:12704113). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells (PubMed:19433802, PubMed:11070175). Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG (PubMed:2145361, PubMed:7718508). Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs (PubMed:10464327). Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5 (PubMed:10464327). Interacts with IL9R (PubMed:2145361). Interacts with IL2RG (PubMed:7718508). Secreted. Deltion mice do not show defects in T-cell development or differentiation, the generation of naive or antigen- driven antibody responses, or the expulsion of the intestinal parasitic nematode Nippostrongylus brasiliensis. However, mastocytosis is severely impaired in these animals. Belongs to the IL-7/IL-9 family. cytokine activity cytokine receptor binding interleukin-9 receptor binding extracellular region extracellular space immune response signal transduction growth factor activity positive regulation of cell growth positive regulation of interleukin-5 biosynthetic process uc007qso.1 uc007qso.2 
ENSMUST00000022023.13 Trpc7 ENSMUST00000022023.13 transient receptor potential cation channel, subfamily C, member 7, transcript variant 1 (from RefSeq NM_012035.3) ENSMUST00000022023.1 ENSMUST00000022023.10 ENSMUST00000022023.11 ENSMUST00000022023.12 ENSMUST00000022023.2 ENSMUST00000022023.3 ENSMUST00000022023.4 ENSMUST00000022023.5 ENSMUST00000022023.6 ENSMUST00000022023.7 ENSMUST00000022023.8 ENSMUST00000022023.9 NM_012035 Q9WVC5 TRPC7_MOUSE Trp7 Trrp8 uc007qtb.1 uc007qtb.2 uc007qtb.3 uc007qtb.4 The protein encoded by this gene is a member of the transient receptor potential channel family of proteins, which form six-transmembrane cation-permeable channels that are calcium permeant. Knock out mice are viable but display a reduction in the gamma wave activity that precedes seizure induction in response to a muscrarinic agonist, suggesting a functional role for this protein in initiation of seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1. Cell membrane ; Multi-pass membrane protein Nucleus envelope Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily. ion channel activity calcium channel activity nucleus nuclear envelope cis-Golgi network plasma membrane integral component of plasma membrane ion transport calcium ion transport manganese ion transport single fertilization store-operated calcium channel activity membrane integral component of membrane cation channel complex perinuclear region of cytoplasm regulation of cytosolic calcium ion concentration transmembrane transport calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding uc007qtb.1 uc007qtb.2 uc007qtb.3 uc007qtb.4 
ENSMUST00000022028.6 1700067P10Rik ENSMUST00000022028.6 RIKEN cDNA 1700067P10 gene (from RefSeq NR_160405.1) 1700067P10Rik ENSMUST00000022028.1 ENSMUST00000022028.2 ENSMUST00000022028.3 ENSMUST00000022028.4 ENSMUST00000022028.5 G3X8U2 G3X8U2_MOUSE NR_160405 uc008cws.1 uc008cws.2 uc008cws.3 molecular_function cellular_component biological_process uc008cws.1 uc008cws.2 uc008cws.3 
ENSMUST00000022030.11 Ccnh ENSMUST00000022030.11 cyclin H, transcript variant 1 (from RefSeq NM_023243.6) CCNH_MOUSE ENSMUST00000022030.1 ENSMUST00000022030.10 ENSMUST00000022030.2 ENSMUST00000022030.3 ENSMUST00000022030.4 ENSMUST00000022030.5 ENSMUST00000022030.6 ENSMUST00000022030.7 ENSMUST00000022030.8 ENSMUST00000022030.9 NM_023243 Q61458 Q9CVJ0 Q9JHV7 uc007riu.1 uc007riu.2 uc007riu.3 Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor. Nucleus. Expressed in both the germinal and somatic cells of the testis. Higher expression during spermatogenesis from the mitotic stages to the meiotic stages. Belongs to the cyclin family. Cyclin C subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity nucleus nucleoplasm holo TFIIH complex transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein phosphorylation cell cycle kinase activity phosphorylation cyclin-dependent protein serine/threonine kinase regulator activity cyclin-dependent protein kinase activating kinase holoenzyme complex positive regulation of transcription from RNA polymerase II promoter protein stabilization TFIIK complex DNA-dependent ATPase activity RNA polymerase II carboxy-terminal domain kinase activity uc007riu.1 uc007riu.2 uc007riu.3 
ENSMUST00000022032.7 Qng1 ENSMUST00000022032.7 Q-nucleotide N-glycosylase 1 (from RefSeq NM_027335.1) 2210016F16Rik ENSMUST00000022032.1 ENSMUST00000022032.2 ENSMUST00000022032.3 ENSMUST00000022032.4 ENSMUST00000022032.5 ENSMUST00000022032.6 G3X8U3 NM_027335 QNG1 QNG1_MOUSE uc007qtr.1 uc007qtr.2 uc007qtr.3 uc007qtr.4 Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. Reaction=H2O + queuosine 5'-phosphate = D-ribose 5-phosphate + queuine; Xref=Rhea:RHEA:75387, ChEBI:CHEBI:15377, ChEBI:CHEBI:17433, ChEBI:CHEBI:78346, ChEBI:CHEBI:194371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75388; Evidence=; Highly expressed in liver. Eukaryotes lack the canonical genes for de novo biosynthesis of queuosine (Q), present in most bacteria. Therefore, this molecule must be sourced from ingested food and/or the gut microbiota, and metabolized to its corresponding nucleobase, queuine (q), before incorporation into cytoplasmic and mitochondrial tRNAs. Incorporation of q into the anticodon of some tRNAs contributes to translational efficiency and accuracy. Belongs to the QNG1 protein family. molecular_function cellular_component tRNA-guanine transglycosylation uc007qtr.1 uc007qtr.2 uc007qtr.3 uc007qtr.4 
ENSMUST00000022036.14 Slc28a3 ENSMUST00000022036.14 solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (from RefSeq NM_022317.3) Cnt3 ENSMUST00000022036.1 ENSMUST00000022036.10 ENSMUST00000022036.11 ENSMUST00000022036.12 ENSMUST00000022036.13 ENSMUST00000022036.2 ENSMUST00000022036.3 ENSMUST00000022036.4 ENSMUST00000022036.5 ENSMUST00000022036.6 ENSMUST00000022036.7 ENSMUST00000022036.8 ENSMUST00000022036.9 NM_022317 Q3UM72 Q8BWE2 Q91VD7 Q9ERH8 S28A3_MOUSE uc007qud.1 uc007qud.2 uc007qud.3 uc007qud.4 Sodium-dependent, pyrimidine- and purine-selective (PubMed:11032837). Involved in the homeostasis of endogenous nucleosides (PubMed:11032837). Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine) (PubMed:11032837). Employs a 2:1 sodium/nucleoside ratio (PubMed:11032837). Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (By similarity). Reaction=2 Na(+)(out) + thymidine(out) = 2 Na(+)(in) + thymidine(in); Xref=Rhea:RHEA:69899, ChEBI:CHEBI:17748, ChEBI:CHEBI:29101; Evidence=; Reaction=cytidine(out) + 2 Na(+)(out) = cytidine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:69903, ChEBI:CHEBI:17562, ChEBI:CHEBI:29101; Evidence=; Reaction=2 Na(+)(out) + uridine(out) = 2 Na(+)(in) + uridine(in); Xref=Rhea:RHEA:69907, ChEBI:CHEBI:16704, ChEBI:CHEBI:29101; Evidence=; Reaction=adenosine(out) + 2 Na(+)(out) = adenosine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:69911, ChEBI:CHEBI:16335, ChEBI:CHEBI:29101; Evidence=; Reaction=guanosine(out) + 2 Na(+)(out) = guanosine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:69915, ChEBI:CHEBI:16750, ChEBI:CHEBI:29101; Evidence=; Reaction=inosine(out) + 2 Na(+)(out) = inosine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:69919, ChEBI:CHEBI:17596, ChEBI:CHEBI:29101; Evidence=; Homotrimer. Cell membrane ; Multi-pass membrane protein Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. retina homeostasis nucleoside transmembrane transporter activity nucleoside:sodium symporter activity integral component of plasma membrane pyrimidine- and adenine-specific:sodium symporter activity purine-specific nucleoside:sodium symporter activity pyrimidine nucleobase transport purine nucleoside transmembrane transport pyrimidine nucleoside transport membrane integral component of membrane sodium ion transmembrane transport pyrimidine-containing compound transmembrane transport nucleoside transmembrane transport purine nucleobase transmembrane transport uc007qud.1 uc007qud.2 uc007qud.3 uc007qud.4 
ENSMUST00000022038.15 Naa35 ENSMUST00000022038.15 N(alpha)-acetyltransferase 35, NatC auxiliary subunit, transcript variant 4 (from RefSeq NR_168734.1) ENSMUST00000022038.1 ENSMUST00000022038.10 ENSMUST00000022038.11 ENSMUST00000022038.12 ENSMUST00000022038.13 ENSMUST00000022038.14 ENSMUST00000022038.2 ENSMUST00000022038.3 ENSMUST00000022038.4 ENSMUST00000022038.5 ENSMUST00000022038.6 ENSMUST00000022038.7 ENSMUST00000022038.8 ENSMUST00000022038.9 Egap Mak10 NAA35_MOUSE NR_168734 Q05CD3 Q6PHQ8 Q8BYJ9 Q8K3H2 uc007quu.1 uc007quu.2 uc007quu.3 uc007quu.4 uc007quu.5 Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells. Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30. Cytoplasm Belongs to the MAK10 family. PubMed:16484612 decribes a Naa35/Egap-containing complex as evolutionary conserved NatC complex; however, the mMak3 protein investigated in this context corresponds to mammalian NAA50 and not NAA30 and its interaction with NAA35 is ambiguous. Sequence=AAH27201.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; peptide alpha-N-acetyltransferase activity protein binding cytoplasm polysome N-terminal protein amino acid acetylation N-terminal peptidyl-methionine acetylation NatC complex negative regulation of apoptotic process smooth muscle cell proliferation uc007quu.1 uc007quu.2 uc007quu.3 uc007quu.4 uc007quu.5 
ENSMUST00000022039.7 Golm1 ENSMUST00000022039.7 golgi membrane protein 1, transcript variant 2 (from RefSeq NM_001035122.2) ENSMUST00000022039.1 ENSMUST00000022039.2 ENSMUST00000022039.3 ENSMUST00000022039.4 ENSMUST00000022039.5 ENSMUST00000022039.6 G3X8U4 GOLM1_MOUSE Golph2 NM_001035122 Q91XA2 uc007qux.1 uc007qux.2 uc007qux.3 Unknown. Cellular response protein to viral infection. Interacts with DYM. Golgi apparatus, cis-Golgi network membrane ; Single-pass type II membrane protein Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption. Up-regulated in response to viral infection. Glycosylated. Phosphorylation sites are present in the extracellular medium. Belongs to the GOLM family. It is uncertain whether Met-1 or Met-2 is the initiator. molecular_function Golgi apparatus nucleus organization membrane integral component of membrane regulation of lipid metabolic process uc007qux.1 uc007qux.2 uc007qux.3 
ENSMUST00000022040.14 Agtpbp1 ENSMUST00000022040.14 ATP/GTP binding protein 1, transcript variant 1 (from RefSeq NM_023328.3) Agtpbp1 CBPC1_MOUSE Ccp1 ENSMUST00000022040.1 ENSMUST00000022040.10 ENSMUST00000022040.11 ENSMUST00000022040.12 ENSMUST00000022040.13 ENSMUST00000022040.2 ENSMUST00000022040.3 ENSMUST00000022040.4 ENSMUST00000022040.5 ENSMUST00000022040.6 ENSMUST00000022040.7 ENSMUST00000022040.8 ENSMUST00000022040.9 NM_023328 Nna1 Q3TDS0 Q3V147 Q641K1 Q6P9R9 Q8C1K8 Q9D962 Q9EQI4 uc007qun.1 uc007qun.2 uc007qun.3 uc007qun.4 Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:21074048, PubMed:22170066, PubMed:25103237, PubMed:30420557, PubMed:29593216). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:22170066, PubMed:25103237, PubMed:30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:21074048). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:21074048, PubMed:22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). Reaction=(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L- glutamate; Xref=Rhea:RHEA:60004, Rhea:RHEA-COMP:15519, Rhea:RHEA- COMP:15675, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:143623; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60005; Evidence= Reaction=C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L- glutamate; Xref=Rhea:RHEA:63792, Rhea:RHEA-COMP:16435, Rhea:RHEA- COMP:16436, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:149555, ChEBI:CHEBI:149556; EC=3.4.17.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63793; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Interacts with MYLK. Cytoplasm Cytoplasm, cytosol Nucleus Mitochondrion Note=Localizes in both the cytoplasm and nuclei of interphase and dividing cells. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q641K1-1; Sequence=Displayed; Name=2; IsoId=Q641K1-2; Sequence=VSP_029047, VSP_029048; Name=3; IsoId=Q641K1-3; Sequence=VSP_029045, VSP_029046; Name=4; IsoId=Q641K1-4; Sequence=VSP_038803, VSP_038805; Name=5; IsoId=Q641K1-5; Sequence=VSP_038804; Widely expressed. Highly expressed in the cerebellum and cortex of adult mouse brain. Expressed at similar levels in both the cerebellum and the cortex throughout all developmental stages. Also expressed in sciatic nerve transection, spinal motor neurons undergoing axon regeneration, testis, heart, eye, lung, pancreas, intestine, stomach, pituitary, spleen, adrenal, kidney and in developing brain. Expression in cranial motor nuclei is the same as that observed in uninjured primary motor neurons. Expression is prevalent in sensory neurons and hippocampal CA3 neurons in addition to regenerating motor neurons. Highly expressed in differentiating neurons. From 16.5 dpc, expression is widespread in brain, spinal cord, and peripheral nervous tissue. Within the developing CNS, expression is restricted to regions of brain and spinal cord containing differentiating neurons. By axonal regeneration. Note=Defects in Agtpbp1 are the cause of Purkinje cell degeneration (pcd). Pcd is a spontaneous mutation that results in adult-onset degeneration of cerebellar Purkinje neurons, retinal photoreceptors, olfactory bulb mitral neurons and selected thalamic neurons, and causes defective spermatogenesis. Pcd mice also manifest cerebellar atrophy and a peripheral nerve degeneration resulting in pure motor or motor-predominant neuropathy. Motoric femoral quadriceps nerves are characterized by reduced total calibers, a loss of myelinated axons, perturbed axon morphology, and macrophage activation. The amount of motor neurons in the ventral horns of lumbar spinal cords is reduced. These anomalies are accompanied by dysregulated tubulin polyglutamylation (PubMed:30420557). Defects in mitochondrial metabolic functions are also observed. The molecular causes of neurodegeneration are probably due to an accumulation of glutamylation, either tubulin hyperglutamylation or another hyperglutamylated target proteins. An increase of intranuclear localization of lysyl oxidase (Lox) propeptide, which interferes with NF-kappa-B Rela signaling and microtubule-associated protein regulation of microtubule stability is also observed, possibly leading to underdevelopment of Purkinje cell dendrites. Knockout pcd mice show hyperglutamylation of alpha- and beta-tubulins in the brain (PubMed:22170066). Knockout mice promote somatic cell reprogramming and higher litter size at birth (PubMed:29593216). [Isoform 3]: Apparent retained intron. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the peptidase M14 family. Sequence=AAG37102.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; eye photoreceptor cell differentiation carboxypeptidase activity metallocarboxypeptidase activity protein binding nucleus nucleolus cytoplasm mitochondrion cytosol proteolysis mitochondrion organization adult walking behavior peptidase activity metallopeptidase activity zinc ion binding tubulin binding hydrolase activity cerebellum development cerebellar Purkinje cell layer development cerebellar Purkinje cell differentiation olfactory bulb development protein deglutamylation C-terminal protein deglutamylation protein side chain deglutamylation neurotransmitter metabolic process intracellular membrane-bounded organelle metal ion binding neuromuscular process retina development in camera-type eye uc007qun.1 uc007qun.2 uc007qun.3 uc007qun.4 
ENSMUST00000022048.6 Slc6a19 ENSMUST00000022048.6 solute carrier family 6 (neurotransmitter transporter), member 19, transcript variant 1 (from RefSeq NM_028878.4) B0at1 ENSMUST00000022048.1 ENSMUST00000022048.2 ENSMUST00000022048.3 ENSMUST00000022048.4 ENSMUST00000022048.5 NM_028878 Q9D687 S6A19_MOUSE Xt3 uc007rdy.1 uc007rdy.2 uc007rdy.3 Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:18424768, PubMed:17167413, PubMed:26240152, PubMed:19185582, PubMed:15044460). This uptake is sodium-dependent and chloride- independent (PubMed:18424768, PubMed:19185582, PubMed:15044460, PubMed:21636576, PubMed:26240152). Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:18424768, PubMed:17167413, PubMed:19185582, PubMed:22677001). Reaction=L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out); Xref=Rhea:RHEA:29283, ChEBI:CHEBI:29101, ChEBI:CHEBI:57972; Evidence=; Reaction=L-cysteine(in) + Na(+)(in) = L-cysteine(out) + Na(+)(out); Xref=Rhea:RHEA:68232, ChEBI:CHEBI:29101, ChEBI:CHEBI:35235; Evidence=; Reaction=L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out); Xref=Rhea:RHEA:68236, ChEBI:CHEBI:29101, ChEBI:CHEBI:58359; Evidence=; Reaction=glycine(in) + Na(+)(in) = glycine(out) + Na(+)(out); Xref=Rhea:RHEA:68228, ChEBI:CHEBI:29101, ChEBI:CHEBI:57305; Evidence=; Reaction=L-isoleucine(in) + Na(+)(in) = L-isoleucine(out) + Na(+)(out); Xref=Rhea:RHEA:29275, ChEBI:CHEBI:29101, ChEBI:CHEBI:58045; Evidence=; Reaction=L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out); Xref=Rhea:RHEA:29263, ChEBI:CHEBI:29101, ChEBI:CHEBI:57427; Evidence=; Reaction=L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out); Xref=Rhea:RHEA:68240, ChEBI:CHEBI:29101, ChEBI:CHEBI:57844; Evidence=; Reaction=L-phenylalanine(in) + Na(+)(in) = L-phenylalanine(out) + Na(+)(out); Xref=Rhea:RHEA:68244, ChEBI:CHEBI:29101, ChEBI:CHEBI:58095; Evidence=; Reaction=L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out); Xref=Rhea:RHEA:29575, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384; Evidence=; Reaction=L-tryptophan(in) + Na(+)(in) = L-tryptophan(out) + Na(+)(out); Xref=Rhea:RHEA:68252, ChEBI:CHEBI:29101, ChEBI:CHEBI:57912; Evidence=; Reaction=L-tyrosine(in) + Na(+)(in) = L-tyrosine(out) + Na(+)(out); Xref=Rhea:RHEA:68248, ChEBI:CHEBI:29101, ChEBI:CHEBI:58315; Evidence=; Reaction=L-valine(in) + Na(+)(in) = L-valine(out) + Na(+)(out); Xref=Rhea:RHEA:29267, ChEBI:CHEBI:29101, ChEBI:CHEBI:57762; Evidence=; Kinetic parameters: KM=630 uM for leucine ; KM=522 uM for glutamine ; KM=589 uM for phenylalanine ; KM=0.99 mM for L-isoleucine ; KM=0.78 mM for L-isoleucine (in presence of CLTRN) ; Note=Vmax for leucine is about twice the value of Vmax for glutamine, and three times the value of Vmax for phenylalanine. KM and Vmax values are complex functions of the concentration of substrate (L- amino acid) and cosubstrate (Na(+)) and the membrane potential.; Interacts in a tissue-specific manner with ACE2 in small intestine and with CLTRN in the kidney (PubMed:19185582, PubMed:17167413). Interacts with CLTRN; this interaction is required for trafficking of SLC6A19 to the plasma membrane and for its catalytic activation in kidneys (PubMed:17167413). Interacts with ACE2; this interaction is required for trafficking of SLC6A19 to the plasma membrane and for its catalytic activation in intestine (PubMed:19185582). Interacts with ANPEP; the interaction positively regulates its amino acid transporter activity (PubMed:22677001). Cell membrane ; Multi-pass membrane protein Note=Localizes in small intestine brush border membranes (at protein level). Predominantly expressed in kidney and small intestine (at protein level) (PubMed:15044460, PubMed:19185582). Expressed in the intestinal brush border (at protein level) (PubMed:22677001). Expression not observed in other organs, such as lung, skeletal muscle, brain, liver and pancreas. In kidney, expression is localized in the renal cortex but not in the medulla. Substantial amounts of expression in the proximal tubules. The distal nephron segments and the glomeruli are consistently negative. In the small intestine, expression is exclusively localized in villus enterocytes. High resolution of the hybridization-positive villi reveals a gradient of expression with the highest levels in apical cells. Not detected in crypt cells or in any other cell types of the small intestine. Deficient mice exhibit reduced growth, impaired body weight control, insulin response and amino acid absorption and excretion. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily. neurotransmitter:sodium symporter activity protein binding plasma membrane integral component of plasma membrane neurotransmitter transport amino acid transport response to nutrient neutral amino acid transmembrane transporter activity symporter activity neutral amino acid transport membrane integral component of membrane apical plasma membrane brush border membrane transmembrane transport uc007rdy.1 uc007rdy.2 uc007rdy.3 
ENSMUST00000022049.5 Slc6a19os ENSMUST00000022049.5 solute carrier family 6 (neurotransmitter transporter), member 19, opposite strand (from RefSeq NR_168890.1) ENSMUST00000022049.1 ENSMUST00000022049.2 ENSMUST00000022049.3 ENSMUST00000022049.4 NR_168890 uc288olv.1 uc288olv.2 uc288olv.1 uc288olv.2 
ENSMUST00000022051.14 Nkd2 ENSMUST00000022051.14 naked cuticle 2, transcript variant 1 (from RefSeq NM_028186.5) ENSMUST00000022051.1 ENSMUST00000022051.10 ENSMUST00000022051.11 ENSMUST00000022051.12 ENSMUST00000022051.13 ENSMUST00000022051.2 ENSMUST00000022051.3 ENSMUST00000022051.4 ENSMUST00000022051.5 ENSMUST00000022051.6 ENSMUST00000022051.7 ENSMUST00000022051.8 ENSMUST00000022051.9 NKD2_MOUSE NM_028186 Q3TYU5 Q3UM34 Q8C4J8 Q8VE28 Q91Y45 Q9D7U9 uc007ref.1 uc007ref.2 uc007ref.3 uc007ref.4 Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells (By similarity). Interacts with RNF25, TGFA (via cytoplasmic domain), and PPP2R3A (By similarity). Interacts with DVL1, DVL2 and DVL3. Cell membrane Cytoplasm Cytoplasmic vesicle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VE28-1; Sequence=Displayed; Name=2; IsoId=Q8VE28-2; Sequence=VSP_027902; Expressed in the cecum, colon, esophagus, ileum, jejunum, skin and stomach. Expressed in the forelimb buds, the branchial arches, the caudal presomitic mesoderm (PSM) and at the anterior and posterior of each somite boundary at 9.5 days postcoitum (dpc). Also expressed in the tailbud. The N-terminal domain comprising the first 224 amino acid residues is mostly unstructured. Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25 (By similarity). Belongs to the NKD family. calcium ion binding cytoplasm plasma membrane exocytosis positive regulation of protein processing membrane Wnt signaling pathway basolateral plasma membrane lateral plasma membrane growth factor binding negative regulation of Wnt signaling pathway cytoplasmic vesicle ubiquitin protein ligase binding myosin heavy chain binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process metal ion binding Golgi vesicle fusion to target membrane ATPase binding exocytic vesicle cell periphery protein localization to plasma membrane negative regulation of canonical Wnt signaling pathway positive regulation of protein localization to plasma membrane uc007ref.1 uc007ref.2 uc007ref.3 uc007ref.4 
ENSMUST00000022053.11 Trip13 ENSMUST00000022053.11 thyroid hormone receptor interactor 13, transcript variant 5 (from RefSeq NR_184787.1) A0JNT8 ENSMUST00000022053.1 ENSMUST00000022053.10 ENSMUST00000022053.2 ENSMUST00000022053.3 ENSMUST00000022053.4 ENSMUST00000022053.5 ENSMUST00000022053.6 ENSMUST00000022053.7 ENSMUST00000022053.8 ENSMUST00000022053.9 NR_184787 PCH2_MOUSE Pch2 Q05CL4 Q3UA06 Q3UQG6 Q9CWW8 uc007rei.1 uc007rei.2 uc007rei.3 Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher- order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (PubMed:17696610, PubMed:19851446, PubMed:20711356). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (By similarity). Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction (By similarity). Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis (PubMed:31437213). Q3UA06; Q99LG4: Ttc5; NbExp=2; IntAct=EBI-308990, EBI-21183045; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UA06-1; Sequence=Displayed; Name=2; IsoId=Q3UA06-2; Sequence=VSP_041559; Widely expressed, including in testis. Mice develop normally without obvious somatic defects but males and females are sterile due to meiotic disruption in meiocytes. Homozygous mutants display small gonads and females have few or no follicles, due to oocyte elimination between pachynema and dictyate. Mutant testes display reduced populated tubules and spermatogenesis is mainly arrested at spermatocyte stages of epithelial stage IV, corresponding to pachynema. Different phenotypes are observed in the different knockout experiments tested. In Trip13(RRB047) mutant mice, also named Trip13(mod) allele for moderate, the number of crossovers are not affected and meiocytes undergo homologous chromosome synapsis despide the presence of unrepaired DSBs in pachynema. Using a more severe mutant allele, named Trip13(sev) for severe, additional defects are observed: the numbers of crossovers and chiasmata are reduced in the absence of TRIP13, and their distribution along the chromosomes is altered (PubMed:20711356). Autosomal bivalents in meiocytes frequently display pericentric synaptic forks and other defects (PubMed:20711356). Recombination defects are evident very early in meiotic prophase, soon after DSB formation (PubMed:20711356). These results suggest that the absence of defects in the number of crossovers observed in Trip13(RRB047) mutant is due to the use of a weak hypomorphic mutant allele. Belongs to the AAA ATPase family. PCH2 subfamily. nucleotide binding oocyte maturation male germ cell nucleus protein binding ATP binding chromosome double-strand break repair mitotic spindle assembly checkpoint synaptonemal complex assembly reciprocal meiotic recombination male meiosis I female meiosis I spermatogenesis spermatid development cell differentiation identical protein binding oogenesis meiotic cell cycle meiotic recombination checkpoint uc007rei.1 uc007rei.2 uc007rei.3 
ENSMUST00000022057.9 Tppp ENSMUST00000022057.9 tubulin polymerization promoting protein (from RefSeq NM_182839.2) ENSMUST00000022057.1 ENSMUST00000022057.2 ENSMUST00000022057.3 ENSMUST00000022057.4 ENSMUST00000022057.5 ENSMUST00000022057.6 ENSMUST00000022057.7 ENSMUST00000022057.8 NM_182839 Q7TQD2 TPPP_MOUSE Tppp uc007reo.1 uc007reo.2 uc007reo.3 Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (By similarity). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:18028908). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (By similarity). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (By similarity). Plays a role in cell proliferation by regulating the G1/S-phase transition (By similarity). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Homodimer. Binds tubulin; binding is inhibited by GTP (By similarity). Interacts with MAPK1. Interacts with GAPDH; the interaction is direct (By similarity). Interacts with LIMK1 (via the PDZ domain); the interaction is direct. Interacts with LIMK2. Interacts with HDAC6; thereby inhibiting the tubulin deacetylase activity of HDAC6. Interacts with aggregated SNCA; may have a pro-aggregatory role in synucleinopathies. Interacts with DYNLL1 (By similarity).Interacts (via C-terminus) with S100A2, S100A6 and S100B; these interactions inhibit TPPP dimerization (By similarity). Golgi outpost Cytoplasm, cytoskeleton, microtubule organizing center Cytoplasm, cytoskeleton Nucleus Cytoplasm, cytoskeleton, spindle Note=Specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity). Mainly localizes to the cytoskeleton (PubMed:18028908). Also found in the nucleus; however, nuclear localization is unclear and requires additional evidences (PubMed:18028908). Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies. During mitosis, colocalizes with LIMK2 at the mitotic spindle (By similarity). Widely expressed with higher expression in brain (at protein level). Most of the protein is composed of disordered regions. Zinc- binding induces structural rearrangement by promoting molten globule state formation. Phosphorylated by LIMK1 on serine residues; phosphorylation may alter the tubulin polymerization activity. Phosphorylation by LIMK2, but not LIMK1, regulates astral microtubule organization at early stage of mitosis. Phosphorylation by ROCK1 at Ser-31, Ser-106 and Ser-158 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin, increased cell motility and entry into S-phase. Phosphorylation by CDK1 inhibits the microtubule polymerizing activity. Degraded by the proteasome; zinc-binding inhibits degradation by the proteasome. Mice display hypomyelination with shorter, thinner myelin sheaths and show breeding and motor coordination deficits (PubMed:31522887). Oligodendrocytes have thinner and more numerous branches in proximal processes (PubMed:31522887). Fewer microtubules are nucleated from Golgi outposts and these are no longer arranged in parallel bundles with their growing plus-ends distal, but show random polarity (PubMed:31522887). Belongs to the TPPP family. microtubule bundle formation nucleus cytoplasm mitochondrion cytosol cytoskeleton microtubule microtubule binding tubulin binding positive regulation of protein complex assembly positive regulation of protein polymerization myelin sheath microtubule polymerization perinuclear region of cytoplasm microtubule bundle uc007reo.1 uc007reo.2 uc007reo.3 
ENSMUST00000022059.14 Ahrr ENSMUST00000022059.14 aryl-hydrocarbon receptor repressor, transcript variant 1 (from RefSeq NM_009644.3) A0A0R4J020 A0A0R4J020_MOUSE Ahrr ENSMUST00000022059.1 ENSMUST00000022059.10 ENSMUST00000022059.11 ENSMUST00000022059.12 ENSMUST00000022059.13 ENSMUST00000022059.2 ENSMUST00000022059.3 ENSMUST00000022059.4 ENSMUST00000022059.5 ENSMUST00000022059.6 ENSMUST00000022059.7 ENSMUST00000022059.8 ENSMUST00000022059.9 NM_009644 uc007rev.1 uc007rev.2 uc007rev.3 This gene encodes a protein that represses aryl hydrocarbon receptor-dependent signaling. The encoded protein competes with the aryl hydrocarbon receptor transcription factor for heterodimerization with the aryl hydrocarbon receptor nuclear translocator protein and binding to xenobiotic response element (XRE) sequence in many genes. This protein is implicated in the regulation of cell growth and differentiation as well as mediating dioxin toxicity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]. nucleus regulation of transcription, DNA-templated xenobiotic metabolic process response to xenobiotic stimulus protein dimerization activity uc007rev.1 uc007rev.2 uc007rev.3 
ENSMUST00000022060.7 Pdcd6 ENSMUST00000022060.7 programmed cell death 6, transcript variant 1 (from RefSeq NM_011051.3) Alg2 ENSMUST00000022060.1 ENSMUST00000022060.2 ENSMUST00000022060.3 ENSMUST00000022060.4 ENSMUST00000022060.5 ENSMUST00000022060.6 NM_011051 P12815 PDCD6_MOUSE Q545I0 Q61145 uc007rey.1 uc007rey.2 uc007rey.3 uc007rey.4 Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair (PubMed:10744743, PubMed:11525164, PubMed:27541325). Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:10744743, PubMed:11525164, PubMed:27541325). Involved in ER- Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:10744743, PubMed:11525164, PubMed:27541325). Together with PEF1, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (By similarity). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (By similarity). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (By similarity). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (By similarity). Required for T-cell receptor-, Fas-, and glucocorticoid- induced apoptosis (PubMed:8560270). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (By similarity). Its role in apoptosis may however be indirect, as suggested by knockout experiments (PubMed:12024023). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (By similarity). [Isoform 2]: Has a lower Ca(2+) affinity than isoform 1 (PubMed:10744743). Homodimer and heterodimer; heterodimerizes (via the EF-hand 5) with PEF1 (PubMed:10200558, PubMed:11525164, PubMed:27541325). Isoform 1 and isoform 2 self-associate; probably forming homodimers (By similarity). Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Interacts with PDCD6IP; the interaction is calcium-dependent (PubMed:10200558, PubMed:10744743, PubMed:11525164). Interacts with RBM22 (By similarity). Interacts with PLSCR4 (By similarity). Interacts with ANXA7 and TSG101 (By similarity). Interacts with DAPK1 (By similarity). Interacts with SEC31A; the interaction is calcium- dependent and promotes monoubiquitination of SEC31A (By similarity). Interacts with ANXA11 (via N-terminus); the interaction is calcium- dependent (By similarity). Interacts with PLSCR3 (via N-terminus); the interaction is calcium-dependent (By similarity). Interacts with MCOLN1; the interaction is calcium-dependent (By similarity). Interacts with KDR; the interaction is calcium-dependent (By similarity). Interacts with HEBP2; the interaction is calcium-dependent (By similarity). Interacts with TFG (By similarity). Isoform 1: Interacts with SHISA5, leading to stabilize it (PubMed:17889823). Isoform 2: Does not interact with SHISA5 (PubMed:17889823). Isoform 2: Does not interact with PDCD6IP, TSG101, ANXA7 and ANXA11 (PubMed:10744743). P12815; P25445: FAS; Xeno; NbExp=2; IntAct=EBI-309164, EBI-494743; P12815; Q8N114: SHISA5; Xeno; NbExp=5; IntAct=EBI-309164, EBI-2115556; Endoplasmic reticulum membrane ; Peripheral membrane protein Cytoplasmic vesicle, COPII-coated vesicle membrane Cytoplasm Nucleus Endosome Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. In response to calcium increase, relocates from cytoplasm to COPII vesicle coat. Localizes to endoplasmic reticulum exit site (ERES). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=ALG-2,5; IsoId=P12815-1; Sequence=Displayed; Name=2; Synonyms=ALG-2,1; IsoId=P12815-2; Sequence=VSP_047715; Interacts with different set of proteins thanks to 3 different hydrophobic pockets. Hydrophobic pockets 1 and 2, which mediate interaction with PDCD6IP, are largely formed by residues from EF-hand 3 (EF3) to 5 (EF5), as well as by Tyr-180 (EF5) of a dimerizing molecule (Pocket 1) and from EF-hand (EF2) to 4 (EF4) (Pocket 2). Hydrophobic pocket 3, which mediates interaction with SEC31A, is mainly formed by residues from EF-hand 1 (EF1) to 3 (EF3). EF-hand 1 (EF1) and 3 (EF3) are the high-affinity calcium- binding sites, while EF-hand 5 (EF5) binds calcium with low-affinity (PubMed:11525164). A one-residue insertion in the EF5-binding loop prevents the glutamyl residue at the C-terminal end of the loop from serving as the canonical bidentate calcium ligand (PubMed:11525164). EF5 acts as a high-affinity magnesium-binding domain instead (PubMed:27541325). Magnesium, may affect dimerization (PubMed:27541325). EF5 may bind either calcium or magnesium depending on the context. No visible phenotype (PubMed:12024023). Mice develop normally and display no obvious immune defect (PubMed:12024023). T-cells retain susceptibility to apoptotic stimuli (PubMed:12024023). Sequence=CAA33064.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane magnesium ion binding angiogenesis positive regulation of endothelial cell proliferation calcium ion binding protein binding nucleus cytoplasm endosome endoplasmic reticulum endoplasmic reticulum membrane intracellular protein transport ER to Golgi vesicle-mediated transport apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of endothelial cell migration ER to Golgi transport vesicle membrane neural crest formation neural crest cell development membrane COPII vesicle coat protein binding, bridging negative regulation of vascular endothelial growth factor receptor signaling pathway cytoplasmic vesicle Cul3-RING ubiquitin ligase complex negative regulation of TOR signaling cellular response to heat vascular endothelial growth factor receptor-2 signaling pathway identical protein binding protein homodimerization activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein anchor positive regulation of angiogenesis metal ion binding protein dimerization activity COPII vesicle coating calcium-dependent protein binding response to calcium ion negative regulation of protein kinase B signaling binding, bridging endoplasmic reticulum exit site positive regulation of protein monoubiquitination uc007rey.1 uc007rey.2 uc007rey.3 uc007rey.4 
ENSMUST00000022062.8 Sdha ENSMUST00000022062.8 succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (from RefSeq NM_023281.1) ENSMUST00000022062.1 ENSMUST00000022062.2 ENSMUST00000022062.3 ENSMUST00000022062.4 ENSMUST00000022062.5 ENSMUST00000022062.6 ENSMUST00000022062.7 NM_023281 Q0QF19 Q3UH25 Q3UKP7 Q3V4B1 Q8K2B3 Q921P5 Q9Z1Z4 SDHA_MOUSE uc007rfa.1 uc007rfa.2 uc007rfa.3 Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor. Reaction=a quinone + succinate = a quinol + fumarate; Xref=Rhea:RHEA:40523, ChEBI:CHEBI:24646, ChEBI:CHEBI:29806, ChEBI:CHEBI:30031, ChEBI:CHEBI:132124; EC=1.3.5.1; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (By similarity). Interacts with SDHAF2/SDH5; interaction is required for FAD attachment (By similarity). Interacts with TRAP1 (By similarity). Interacts with LACC1 (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Acetylation of Lys-498 and Lys-538 is observed in liver mitochondria from fasted mice but not from fed mice. Deacetylated by SIRT3. Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. succinate dehydrogenase activity nucleolus mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) tricarboxylic acid cycle succinate metabolic process mitochondrial electron transport, succinate to ubiquinone nervous system development succinate dehydrogenase (ubiquinone) activity electron carrier activity membrane oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors electron transport chain respiratory electron transport chain myelin sheath flavin adenine dinucleotide binding oxidation-reduction process uc007rfa.1 uc007rfa.2 uc007rfa.3 
ENSMUST00000022063.14 Ccdc127 ENSMUST00000022063.14 coiled-coil domain containing 127, transcript variant 2 (from RefSeq NM_024201.3) CC127_MOUSE ENSMUST00000022063.1 ENSMUST00000022063.10 ENSMUST00000022063.11 ENSMUST00000022063.12 ENSMUST00000022063.13 ENSMUST00000022063.2 ENSMUST00000022063.3 ENSMUST00000022063.4 ENSMUST00000022063.5 ENSMUST00000022063.6 ENSMUST00000022063.7 ENSMUST00000022063.8 ENSMUST00000022063.9 NM_024201 Q3TC33 Q3TPA8 Q9CQ15 uc007rfc.1 uc007rfc.2 uc007rfc.3 uc007rfc.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TC33-1; Sequence=Displayed; Name=2; IsoId=Q3TC33-2; Sequence=VSP_021885, VSP_021886; molecular_function cellular_component biological_process uc007rfc.1 uc007rfc.2 uc007rfc.3 uc007rfc.4 
ENSMUST00000022064.5 Lrrc14b ENSMUST00000022064.5 leucine rich repeat containing 14B (from RefSeq NM_001033042.3) ENSMUST00000022064.1 ENSMUST00000022064.2 ENSMUST00000022064.3 ENSMUST00000022064.4 LR14B_MOUSE Lrrc14b NM_001033042 Q3UJB3 Q6P1Y3 uc007rfe.1 uc007rfe.2 uc007rfe.3 Belongs to the PRAME family. LRRC14 subfamily. Sequence=AAH64819.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cytoplasm biological_process uc007rfe.1 uc007rfe.2 uc007rfe.3 
ENSMUST00000022075.6 Pcsk1 ENSMUST00000022075.6 proprotein convertase subtilisin/kexin type 1, transcript variant 1 (from RefSeq NM_013628.3) ENSMUST00000022075.1 ENSMUST00000022075.2 ENSMUST00000022075.3 ENSMUST00000022075.4 ENSMUST00000022075.5 NM_013628 Pcsk1 Q32MU0 Q32MU0_MOUSE uc007rfs.1 uc007rfs.2 uc007rfs.3 Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP. Reaction=Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.; EC=3.4.21.93; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Cytoplasmic vesicle, secretory vesicle Vesicle Belongs to the peptidase S8 family. Furin subfamily. serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc007rfs.1 uc007rfs.2 uc007rfs.3 
ENSMUST00000022078.12 Rhobtb3 ENSMUST00000022078.12 Rho-related BTB domain containing 3, transcript variant 1 (from RefSeq NM_028493.3) ENSMUST00000022078.1 ENSMUST00000022078.10 ENSMUST00000022078.11 ENSMUST00000022078.2 ENSMUST00000022078.3 ENSMUST00000022078.4 ENSMUST00000022078.5 ENSMUST00000022078.6 ENSMUST00000022078.7 ENSMUST00000022078.8 ENSMUST00000022078.9 Kiaa0878 NM_028493 Q05DP2 Q3UTS4 Q80X55 Q9CTN4 Q9CVT0 RHBT3_MOUSE uc007rfy.1 uc007rfy.2 uc007rfy.3 Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9 (By similarity). Interacts with RAB9A and RAB9B (at lower level compared to RAB9A-binding). Interacts with M6PRBP1/TIP47 (By similarity). Golgi apparatus Sequence=AAH05664.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC98044.1; Type=Erroneous initiation; Evidence=; nucleotide binding GTPase activity protein binding ATP binding GTP binding cytoplasm Golgi apparatus cytosol plasma membrane cell cortex actin filament organization establishment or maintenance of cell polarity Rho protein signal transduction motor neuron axon guidance regulation of cell shape male gonad development vesicle-mediated transport hydrolase activity ATPase activity Rab GTPase binding protein kinase binding actin cytoskeleton organization regulation of actin cytoskeleton organization retrograde transport, endosome to Golgi cell projection engulfment of apoptotic cell uc007rfy.1 uc007rfy.2 uc007rfy.3 
ENSMUST00000022081.3 Spata9 ENSMUST00000022081.3 spermatogenesis associated 9 (from RefSeq NM_029343.3) ENSMUST00000022081.1 ENSMUST00000022081.2 NM_029343 Q9D4M8 Q9D9R3 SPAT9_MOUSE uc007rgb.1 uc007rgb.2 uc007rgb.3 May play at role in testicular development/spermatogenesis and may be an important factor in male infertility. Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D9R3-1; Sequence=Displayed; Name=2; IsoId=Q9D9R3-2; Sequence=VSP_023285, VSP_023286; In the 7-week-old, expressed in spermatogenic cells at every stage, (spermatogonium, primary spermatocyte, spermatid, and mature sperm). Expression levels increased during spermatogenesis. No expression in Leydig cells. molecular_function cellular_component multicellular organism development spermatogenesis biological_process membrane integral component of membrane cell differentiation uc007rgb.1 uc007rgb.2 uc007rgb.3 
ENSMUST00000022082.8 Glrx ENSMUST00000022082.8 glutaredoxin, transcript variant 1 (from RefSeq NM_053108.4) ENSMUST00000022082.1 ENSMUST00000022082.2 ENSMUST00000022082.3 ENSMUST00000022082.4 ENSMUST00000022082.5 ENSMUST00000022082.6 ENSMUST00000022082.7 GLRX1_MOUSE Glrx1 Grx Grx1 NM_053108 Q9QUH0 uc007rfx.1 uc007rfx.2 uc007rfx.3 uc007rfx.4 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Cytoplasm. Belongs to the glutaredoxin family. nucleus cytoplasm mitochondrion mitochondrial intermembrane space cytosol electron carrier activity protein disulfide oxidoreductase activity glutathione disulfide oxidoreductase activity protein-disulfide reductase (glutathione) activity electron transport chain dendrite positive regulation of insulin secretion neuronal cell body cell redox homeostasis positive regulation of membrane potential positive regulation of exocytosis protein N-terminus binding oxidation-reduction process positive regulation of cell adhesion molecule production cellular response to estradiol stimulus positive regulation of NIK/NF-kappaB signaling negative regulation of hydrogen peroxide-mediated programmed cell death negative regulation of platelet-derived growth factor receptor-beta signaling pathway positive regulation of sodium ion transmembrane transporter activity uc007rfx.1 uc007rfx.2 uc007rfx.3 uc007rfx.4 
ENSMUST00000022087.7 Nsun2 ENSMUST00000022087.7 RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:22144916, PubMed:23871666, PubMed:31199786). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:22144916, PubMed:22885326, PubMed:23401851, PubMed:31199786). Methylates cytosine to 5- methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:22885326, PubMed:23871666, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587, PubMed:31287866). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (By similarity). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (By similarity). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (By similarity). May act downstream of Myc to regulate epidermal cell growth and proliferation (PubMed:16713953). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). (from UniProt Q1HFZ0) A0PJD6 AK030124 D13Wsu123e ENSMUST00000022087.1 ENSMUST00000022087.2 ENSMUST00000022087.3 ENSMUST00000022087.4 ENSMUST00000022087.5 ENSMUST00000022087.6 Misu NSUN2_MOUSE Nsun2 Q1HFZ0 Q3U972 Q8BPG9 Q8CDF9 Q91YX9 uc007rcn.1 uc007rcn.2 uc007rcn.3 uc007rcn.4 RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:22144916, PubMed:23871666, PubMed:31199786). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:22144916, PubMed:22885326, PubMed:23401851, PubMed:31199786). Methylates cytosine to 5- methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:22885326, PubMed:23871666, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587, PubMed:31287866). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (By similarity). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (By similarity). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (By similarity). May act downstream of Myc to regulate epidermal cell growth and proliferation (PubMed:16713953). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). Reaction=cytidine(48) in tRNA + S-adenosyl-L-methionine = 5- methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42948, Rhea:RHEA-COMP:10293, Rhea:RHEA-COMP:10297, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42949; Evidence= Reaction=cytidine(49) in tRNA + S-adenosyl-L-methionine = 5- methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42952, Rhea:RHEA-COMP:10294, Rhea:RHEA-COMP:10385, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42953; Evidence= Reaction=cytidine(50) in tRNA + S-adenosyl-L-methionine = 5- methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61488, Rhea:RHEA-COMP:15838, Rhea:RHEA-COMP:15839, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61489; Evidence= Reaction=cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5- methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:42940, Rhea:RHEA-COMP:10291, Rhea:RHEA- COMP:10295, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; EC=2.1.1.203; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42941; Evidence=; Reaction=a cytidine in mRNA + S-adenosyl-L-methionine = a 5- methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61464, Rhea:RHEA-COMP:15145, Rhea:RHEA-COMP:15826, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61465; Evidence=; Inhibited by magnesium ions. Interacts with NPM1 and NCL during interphase; interaction is disrupted following phosphorylation at Ser-139. Nucleus, nucleolus toplasm Mitochondrion Cytoplasm, cytoskeleton, spindle Secreted, extracellular exosome Note=Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA (PubMed:19596847). In testis, localizes to the chromatoid body (PubMed:23401851). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q1HFZ0-1; Sequence=Displayed; Name=2; IsoId=Q1HFZ0-2; Sequence=VSP_025969; Ubiquitously expressed at low level (PubMed:16713953). Up-regulated in tumors (PubMed:16713953). Dynamically expressed during morphogenesis and in adult skin: in adult skin, expression is up-regulated in the bulge and hair germ as soon as the hair follicle enters its growing phase (anagen) (PubMed:22144916). During anagen, expressed at highest level in cells of the hair germ that give rise to the hair matrix (PubMed:22144916). Detected from 3.5 dpc in the inner cell mass of the blastocyst (PubMed:22144916). Expressed throughout the extra- embryonic ectoderm, which gives rise to the nervous system and epidermis, after implantation and gastrulation (PubMed:22144916). Starting from 9.5 dpc, expression becomes more restricted and at 13.5 and 14.5 dpc it is enriched in developing whiskers and eyes (PubMed:22144916). From 15.5 dpc, when the interfollicular epidermis begins to stratify and follicular morphogenesis starts by forming hair placodes, highest expression is observed in the suprabasal layer of interfollicular epidermis (PubMed:22144916). By Myc (at protein level). Phosphorylated at Ser-139 by AURKB during mitosis, leading to abolish methyltransferase activity and the interaction with NPM1. Mice are viable but show male sterility (PubMed:22144916, PubMed:23401851). Mice display reduced body weight and partial alopecia; alopecia is caused by impaired stem cell differentiation in the epidermis, leading to a delay in initiation of anagen (PubMed:22144916). Mice lacking both Nsun2 and Trdmt1 display a complete loss of cytosine-C5 tRNA methylation, leading to development defects and impaired cellular differentiation causing lethality before P3 (PubMed:22885326). Male sterility is caused by impaired germ cell differentiation in the testis: meiotic progression of germ cells is blocked into the pachytene stage, while spermatogonial and Sertoli cells are unaffected (PubMed:23401851). Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily. Sequence=AAH13625.1; Type=Erroneous initiation; Evidence=; Sequence=AAH25549.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC36110.1; Type=Erroneous initiation; Evidence=; tRNA binding in utero embryonic development RNA binding nucleus nucleolus cytoplasm spindle cytoskeleton cell cycle spermatid development tRNA processing methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity transferase activity tRNA methylation methylation meiotic cell cycle checkpoint chromatoid body hair follicle maturation cell division uc007rcn.1 uc007rcn.2 uc007rcn.3 uc007rcn.4 
ENSMUST00000022089.10 Med10 ENSMUST00000022089.10 mediator complex subunit 10, transcript variant 1 (from RefSeq NM_138596.2) D13Wsu50e ENSMUST00000022089.1 ENSMUST00000022089.2 ENSMUST00000022089.3 ENSMUST00000022089.4 ENSMUST00000022089.5 ENSMUST00000022089.6 ENSMUST00000022089.7 ENSMUST00000022089.8 ENSMUST00000022089.9 MED10_MOUSE NM_138596 Q3U0W8 Q80VV0 Q9CXU0 uc007rcq.1 uc007rcq.2 uc007rcq.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Nucleus Belongs to the Mediator complex subunit 10 family. ubiquitin ligase complex transcription cofactor activity nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter protein ubiquitination mediator complex stem cell population maintenance positive regulation of transcription from RNA polymerase II promoter ubiquitin protein ligase activity uc007rcq.1 uc007rcq.2 uc007rcq.3 
ENSMUST00000022097.6 Ndufs6 ENSMUST00000022097.6 NADH:ubiquinone oxidoreductase core subunit S6, transcript variant 1 (from RefSeq NM_010888.3) ENSMUST00000022097.1 ENSMUST00000022097.2 ENSMUST00000022097.3 ENSMUST00000022097.4 ENSMUST00000022097.5 Ip13 NDUS6_MOUSE NM_010888 P52503 Q5M9J7 uc007rdh.1 uc007rdh.2 uc007rdh.3 uc007rdh.4 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Male and female mice are fertile but produce smaller litters and pups have a lower neonatal survival rate (PubMed:22474353). While mice are normal during the first 4 months of life, they are prone to rapid onset weight loss and sudden death after this period (PubMed:22474353). They display cardiomyopathy associated with a doubling of heart weight, impaired systolic function and a reduction in functional capacity (PubMed:22474353). Males are most severely affected, with a propensity to develop cardiac failure and diminished survival after 4 months of age (PubMed:22474353). Defects are due to membrane respiratory chain NADH dehydrogenase (Complex I) deficiency (PubMed:22474353). In the knockout experiment described above, mice show a complete knockout of Ndufs6 subunit in heart resulting in marked complex I deficiency, but small amounts of wild- type Ndufs6 mRNA are still present in other tissues, probably due to tissue-specific mRNA splicing, resulting in milder complex I defects (PubMed:22474353). Belongs to the complex I NDUFS6 subunit family. molecular_function mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial electron transport, NADH to ubiquinone fatty acid metabolic process muscle contraction multicellular organism aging membrane respiratory electron transport chain multicellular organism growth oxidation-reduction process reproductive system development respiratory chain mitochondrion morphogenesis cardiovascular system development uc007rdh.1 uc007rdh.2 uc007rdh.3 uc007rdh.4 
ENSMUST00000022100.7 Slc6a3 ENSMUST00000022100.7 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (from RefSeq NM_010020.3) Dat Dat1 ENSMUST00000022100.1 ENSMUST00000022100.2 ENSMUST00000022100.3 ENSMUST00000022100.4 ENSMUST00000022100.5 ENSMUST00000022100.6 NM_010020 Q60719 Q61327 Q9R1I2 SC6A3_MOUSE uc007rdn.1 uc007rdn.2 Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:12606774). Also mediates sodium- and chloride- dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (PubMed:30936473). Reaction=chloride(out) + dopamine(out) + Na(+)(out) = chloride(in) + dopamine(in) + Na(+)(in); Xref=Rhea:RHEA:70919, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:59905; Evidence=; Reaction=(R)-noradrenaline(out) + chloride(out) + Na(+)(out) = (R)- noradrenaline(in) + chloride(in) + Na(+)(in); Xref=Rhea:RHEA:70923, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:72587; Evidence=; Reaction=chloride(out) + dopamine(out) + 2 Na(+)(out) = chloride(in) + dopamine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70931, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:59905; Evidence=; Inhibited by amphetamine, bupropion, cocaine and ritalin. Kinetic parameters: KM=2 uM for dopamine ; KM=2.1 uM for dopamine ; Homooligomer; disulfide-linked (By similarity). Interacts with PRKCABP and TGFB1I1 (PubMed:12177201). Interacts (via N-terminus) with SYNGR3 (via N-terminus) (PubMed:19357284). Interacts with SLC18A2 (PubMed:19357284). Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location. Interacts with alpha-synuclein/SNCA (By similarity). Interacts with SEPTIN4 (PubMed:17296554). Q61327; O55042: Snca; NbExp=5; IntAct=EBI-7839708, EBI-2310271; Q61327; P37840: SNCA; Xeno; NbExp=5; IntAct=EBI-7839708, EBI-985879; Cell membrane ; Multi-pass membrane protein Cell projection, neuron projection Cell projection, axon Note=Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (PubMed:17296554). Found in the substantia nigra and ventral tegmental dopamine neurons, in fibers of the medial forebrain bundle ascending into the striatum, and within dense fiber networks and varicosities in the dorsal and ventral striatum (at protein level) (PubMed:19357284, PubMed:17296554). Lower expression in the cortex (at protein level) (PubMed:19357284). Absent from the corpus callosum (PubMed:19357284). Expressed throughout the retina at postnatal day 8 (PubMed:30936473). This protein is the target of psychomotor stimulants such as amphetamines and cocaine. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. neurotransmitter uptake protease binding receptor binding neurotransmitter:sodium symporter activity dopamine:sodium symporter activity norepinephrine:sodium symporter activity protein binding plasma membrane integral component of plasma membrane neurotransmitter transport aging lactation sensory perception of smell locomotory behavior drug binding monoamine transmembrane transporter activity cell surface response to iron ion response to organic cyclic compound symporter activity monoamine transport dopamine transport norepinephrine transport membrane integral component of membrane flotillin complex adenohypophysis development axon neuronal cell body membrane response to nicotine dopamine binding positive regulation of multicellular organism growth regulation of dopamine metabolic process response to cocaine dopamine biosynthetic process dopamine catabolic process response to drug presynaptic membrane neuron projection neuronal cell body macromolecular complex binding membrane raft response to ethanol metal ion binding protein N-terminus binding dopamine uptake involved in synaptic transmission response to cAMP norepinephrine uptake protein phosphatase 2A binding transmembrane transport prepulse inhibition dopamine uptake integral component of postsynaptic membrane integral component of presynaptic membrane uc007rdn.1 uc007rdn.2 
ENSMUST00000022102.9 Clptm1l ENSMUST00000022102.9 CLPTM1-like (from RefSeq NM_146047.2) CLP1L_MOUSE ENSMUST00000022102.1 ENSMUST00000022102.2 ENSMUST00000022102.3 ENSMUST00000022102.4 ENSMUST00000022102.5 ENSMUST00000022102.6 ENSMUST00000022102.7 ENSMUST00000022102.8 NM_146047 Q3U176 Q8BXA5 Q8C053 Q8R0P2 uc007rdo.1 uc007rdo.2 uc007rdo.3 uc007rdo.4 Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn- glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3- phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro. Reaction=an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D- myo-inositol(in) = an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3- phospho)-1D-myo-inositol(out); Xref=Rhea:RHEA:71491, ChEBI:CHEBI:57997; Evidence=; Reaction=6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl- sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(alpha-D-glucosaminyl)- (1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo- inositol(out); Xref=Rhea:RHEA:71495, ChEBI:CHEBI:190691; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out); Xref=Rhea:RHEA:38691, ChEBI:CHEBI:57880; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2- diacyl-sn-glycero-3-phosphoethanolamine(out); Xref=Rhea:RHEA:38895, ChEBI:CHEBI:64612; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the CLPTM1 family. Sequence=AAH26562.1; Type=Erroneous initiation; Evidence=; Sequence=BAC27798.1; Type=Frameshift; Evidence=; molecular_function apoptotic process biological_process membrane integral component of membrane uc007rdo.1 uc007rdo.2 uc007rdo.3 uc007rdo.4 
ENSMUST00000022104.9 Tert ENSMUST00000022104.9 telomerase reverse transcriptase, transcript variant 1 (from RefSeq NM_009354.2) ENSMUST00000022104.1 ENSMUST00000022104.2 ENSMUST00000022104.3 ENSMUST00000022104.4 ENSMUST00000022104.5 ENSMUST00000022104.6 ENSMUST00000022104.7 ENSMUST00000022104.8 NM_009354 O35432 O70372 Q9JK99 TERT_MOUSE uc007rdq.1 uc007rdq.2 uc007rdq.3 Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex- associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis (By similarity). Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence= Catalytic component of the telomerase holoenzyme complex composed of one molecule of TERT, one molecule of WRAP53/TCAB1, two molecules of H/ACA ribonucleoprotein complex subunits DKC1, NOP10, NHP2 and GAR1, and a telomerase RNA template component (TERC). The telomerase holoenzyme complex is associated with TEP1, SMG6/EST1A and POT1. The molecular chaperone HSP90/P23 complex is required for correct assembly and stabilization of the active telomerase. Interacts directly with HSP90A and PTGES3. Interacts with HSPA1A; the interaction occurs in the absence of TERC and dissociates once the complex has formed. Interacts with RAN; the interaction promotes nuclear export of TERT. Interacts with XPO1. Interacts with PTPN11; the interaction retains TERT in the nucleus. Interacts with NCL (via RRM1 and C-terminal RRM4/Arg/Gly-rich domains); the interaction is important for nucleolar localization of TERT (By similarity). Interacts with SMARCA4 (via the bromodomain); the interaction regulates Wnt-mediated signaling (PubMed:19571879). Interacts with MCRS1 (isoform MCRS2); the interaction inhibits in vitro telomerase activity (By similarity). Interacts with PIF1; the interaction has no effect on the elongation activity of TERT (PubMed:17130244). Interacts with PML; the interaction recruits TERT to PML bodies and inhibits telomerase activity (By similarity). Interacts with GNL3L (PubMed:19487455). Interacts with isoform 1 and isoform 2 of NVL (By similarity). Interacts with DHX36 (By similarity). Interacts with ATF7 (By similarity). O70372; Q3TKT4: Smarca4; NbExp=2; IntAct=EBI-9662790, EBI-1210244; Nucleus, nucleolus Nucleus, nucleoplasm Nucleus. Chromosome, telomere. Cytoplasm Nucleus, PML body Note=Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress-mediated phosphorylation at Tyr-697. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT (By similarity). High activity in intestine, liver and testis, moderate in lung, very low in muscle, heart and brain. Highest levels in midgestational stages, 9.5 dpc to 15.5 dpc. The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers. The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity (By similarity). The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA synthesis. Phosphorylation at Tyr-697 under oxidative stress leads to translocation of TERT to the cytoplasm and reduces its antiapoptotic activity. Dephosphorylated by SHP2/PTPN11 leading to nuclear retention. Phosphorylation by the AKT pathway promotes nuclear location. Phosphorylation at the G2/M phase at Ser-447 by DYRK2 promotes ubiquitination by the EDVP complex and degradation (By similarity). Ubiquitinated by the EDVP complex, a E3 ligase complex following phosphorylation at Ser-447 by DYRK2. Ubiquitinated leads to proteasomal degradation (By similarity). Belongs to the reverse transcriptase family. Telomerase subfamily. Was originally thought to originate from rat. tRNA binding telomerase catalytic core complex chromosome, telomeric region nuclear chromosome, telomeric region transcription, RNA-templated transcription coactivator binding DNA binding telomerase activity telomerase RNA reverse transcriptase activity RNA binding RNA-directed DNA polymerase activity RNA-directed 5'-3' RNA polymerase activity protein binding nucleus nucleoplasm chromosome telomerase holoenzyme complex nucleolus cytoplasm mitochondrion cytosol plasma membrane RNA-dependent DNA biosynthetic process telomere maintenance via telomerase mitochondrion organization protein C-terminus binding negative regulation of gene expression PML body nuclear speck transferase activity nucleotidyltransferase activity DNA strand elongation positive regulation of Wnt signaling pathway production of siRNA involved in RNA interference RNA-directed RNA polymerase complex regulation of protein stability positive regulation of protein binding telomeric DNA binding positive regulation of hair cycle mitochondrial nucleoid identical protein binding protein homodimerization activity negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of angiogenesis positive regulation of glucose import response to cadmium ion metal ion binding protein N-terminus binding positive regulation of nitric-oxide synthase activity chaperone binding negative regulation of glial cell proliferation telomerase RNA binding establishment of protein localization to telomere cellular response to hypoxia DNA biosynthetic process replicative senescence positive regulation of G1/S transition of mitotic cell cycle positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of transdifferentiation negative regulation of production of siRNA involved in RNA interference regulation of histone demethylase activity (H3-K4 specific) positive regulation of vascular smooth muscle cell proliferation positive regulation of protein localization to nucleolus positive regulation of vascular associated smooth muscle cell migration TERT-RMRP complex negative regulation of endothelial cell apoptotic process positive regulation of stem cell proliferation negative regulation of cellular senescence negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc007rdq.1 uc007rdq.2 uc007rdq.3 
ENSMUST00000022108.9 Hapln1 ENSMUST00000022108.9 hyaluronan and proteoglycan link protein 1 (from RefSeq NM_013500.4) Crtl1 ENSMUST00000022108.1 ENSMUST00000022108.2 ENSMUST00000022108.3 ENSMUST00000022108.4 ENSMUST00000022108.5 ENSMUST00000022108.6 ENSMUST00000022108.7 ENSMUST00000022108.8 HPLN1_MOUSE NM_013500 Q9D1G9 Q9QUP5 Q9Z1X7 uc007rjf.1 uc007rjf.2 uc007rjf.3 uc007rjf.4 Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. Secreted, extracellular space, extracellular matrix. Ubiquitously expressed. Belongs to the HAPLN family. skeletal system development hyaluronic acid binding extracellular region cell adhesion central nervous system development extracellular matrix structural constituent conferring compression resistance extracellular matrix synapse uc007rjf.1 uc007rjf.2 uc007rjf.3 uc007rjf.4 
ENSMUST00000022115.14 Xrcc4 ENSMUST00000022115.14 X-ray repair complementing defective repair in Chinese hamster cells 4 (from RefSeq NM_028012.4) A0A0R4J024 A0A0R4J024_MOUSE ENSMUST00000022115.1 ENSMUST00000022115.10 ENSMUST00000022115.11 ENSMUST00000022115.12 ENSMUST00000022115.13 ENSMUST00000022115.2 ENSMUST00000022115.3 ENSMUST00000022115.4 ENSMUST00000022115.5 ENSMUST00000022115.6 ENSMUST00000022115.7 ENSMUST00000022115.8 ENSMUST00000022115.9 NM_028012 Xrcc4 uc007rjn.1 uc007rjn.2 uc007rjn.3 uc007rjn.4 Nucleus Belongs to the XRCC4-XLF family. XRCC4 subfamily. DNA binding nucleus nucleoplasm cytosol DNA-dependent protein kinase-DNA ligase 4 complex double-strand break repair double-strand break repair via nonhomologous end joining DNA recombination protein C-terminus binding response to X-ray DNA ligase IV complex identical protein binding DNA ligation involved in DNA repair positive regulation of ligase activity nonhomologous end joining complex cellular response to lithium ion uc007rjn.1 uc007rjn.2 uc007rjn.3 uc007rjn.4 
ENSMUST00000022119.6 Atg10 ENSMUST00000022119.6 autophagy related 10, transcript variant 1 (from RefSeq NM_025770.4) A0A0R4J029 A0A0R4J029_MOUSE Atg10 ENSMUST00000022119.1 ENSMUST00000022119.2 ENSMUST00000022119.3 ENSMUST00000022119.4 ENSMUST00000022119.5 NM_025770 uc007rjr.1 uc007rjr.2 uc007rjr.3 Belongs to the ATG10 family. autophagy ER overload response protein modification by small protein conjugation uc007rjr.1 uc007rjr.2 uc007rjr.3 
ENSMUST00000022120.5 Acot12 ENSMUST00000022120.5 acyl-CoA thioesterase 12, transcript variant 1 (from RefSeq NM_028790.4) ACO12_MOUSE Cach Cach1 ENSMUST00000022120.1 ENSMUST00000022120.2 ENSMUST00000022120.3 ENSMUST00000022120.4 NM_028790 Q544M5 Q8R108 Q9DBK0 uc007rka.1 uc007rka.2 uc007rka.3 Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes acetyl-CoA. Reaction=acetyl-CoA + H2O = acetate + CoA + H(+); Xref=Rhea:RHEA:20289, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=3.1.2.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20290; Evidence=; Reaction=butanoyl-CoA + H2O = butanoate + CoA + H(+); Xref=Rhea:RHEA:40111, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40112; Evidence=; Reaction=H2O + hexanoyl-CoA = CoA + H(+) + hexanoate; Xref=Rhea:RHEA:40115, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57287, ChEBI:CHEBI:62620; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40116; Evidence=; Allosterically regulated by ATP (activator) and ADP (inhibitor) (By similarity). Cold labile, it dissociates into inactive monomers at low temperature (By similarity). Lipid metabolism; fatty acid metabolism. Homodimer or homotetramer. Cytoplasm, cytosol fatty-acyl-CoA binding acetyl-CoA hydrolase activity ATP binding cytoplasm cytosol acetyl-CoA metabolic process lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process lipid binding hydrolase activity thiolester hydrolase activity long-chain fatty acyl-CoA binding protein homodimerization activity acyl-CoA hydrolase activity protein homotetramerization carboxylic ester hydrolase activity uc007rka.1 uc007rka.2 uc007rka.3 
ENSMUST00000022121.13 Zcchc9 ENSMUST00000022121.13 zinc finger, CCHC domain containing 9 (from RefSeq NM_145453.2) E9QQ14 ENSMUST00000022121.1 ENSMUST00000022121.10 ENSMUST00000022121.11 ENSMUST00000022121.12 ENSMUST00000022121.2 ENSMUST00000022121.3 ENSMUST00000022121.4 ENSMUST00000022121.5 ENSMUST00000022121.6 ENSMUST00000022121.7 ENSMUST00000022121.8 ENSMUST00000022121.9 NM_145453 Q8R1J3 Q921T6 ZCHC9_MOUSE uc007rkb.1 uc007rkb.2 uc007rkb.3 May down-regulate transcription mediated by NF-kappa-B and the serum response element. Nucleus, nucleolus Nucleus Note=Expressed throughout the nucleus and concentrated mainly in the nucleolus. Detected in brain cortex and in testis. Sequence=BC010687; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; nucleic acid binding cellular_component nucleus nucleolus zinc ion binding negative regulation of phosphatase activity metal ion binding uc007rkb.1 uc007rkb.2 uc007rkb.3 
ENSMUST00000022122.4 Ckmt2 ENSMUST00000022122.4 creatine kinase, mitochondrial 2 (from RefSeq NM_198415.4) ENSMUST00000022122.1 ENSMUST00000022122.2 ENSMUST00000022122.3 KCRS_MOUSE NM_198415 Q6P8J7 uc007rkc.1 uc007rkc.2 Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). Reaction=ATP + creatine = ADP + H(+) + N-phosphocreatine; Xref=Rhea:RHEA:17157, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57947, ChEBI:CHEBI:58092, ChEBI:CHEBI:456216; EC=2.7.3.2; Evidence=; Exists as an octamer composed of four CKMT2 homodimers. Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side Mitochondrial creatine kinase binds cardiolipin. Belongs to the ATP:guanido phosphotransferase family. nucleotide binding catalytic activity creatine kinase activity ATP binding mitochondrion mitochondrial inner membrane phosphocreatine metabolic process membrane kinase activity phosphorylation transferase activity transferase activity, transferring phosphorus-containing groups phosphocreatine biosynthetic process cardiolipin binding uc007rkc.1 uc007rkc.2 
ENSMUST00000022124.10 Cd180 ENSMUST00000022124.10 CD180 antigen, transcript variant 1 (from RefSeq NM_008533.2) CD180_MOUSE ENSMUST00000022124.1 ENSMUST00000022124.2 ENSMUST00000022124.3 ENSMUST00000022124.4 ENSMUST00000022124.5 ENSMUST00000022124.6 ENSMUST00000022124.7 ENSMUST00000022124.8 ENSMUST00000022124.9 Ly78 NM_008533 Q62192 Q8C251 Rp105 uc007rry.1 uc007rry.2 uc007rry.3 May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF- kappa-B activation. Also involved in the life/death decision of B- cells. M-shaped tetramer of two CD180-LY86 heterodimers. Q62192; O88188: Ly86; NbExp=5; IntAct=EBI-79487, EBI-79494; Cell membrane; Single-pass type I membrane protein. B-lymphocytes and spleen. Not detected in thymus, kidney, muscle, heart, brain or liver. Belongs to the Toll-like receptor family. B cell proliferation involved in immune response immune system process protein binding extracellular space plasma membrane inflammatory response membrane integral component of membrane extracellular matrix positive regulation of lipopolysaccharide-mediated signaling pathway innate immune response cellular response to lipopolysaccharide uc007rry.1 uc007rry.2 uc007rry.3 
ENSMUST00000022135.15 Ak6 ENSMUST00000022135.15 adenylate kinase 6 (from RefSeq NM_027592.3) Cinap ENSMUST00000022135.1 ENSMUST00000022135.10 ENSMUST00000022135.11 ENSMUST00000022135.12 ENSMUST00000022135.13 ENSMUST00000022135.14 ENSMUST00000022135.2 ENSMUST00000022135.3 ENSMUST00000022135.4 ENSMUST00000022135.5 ENSMUST00000022135.6 ENSMUST00000022135.7 ENSMUST00000022135.8 ENSMUST00000022135.9 KAD6_MOUSE NM_027592 Q8VCP8 uc007rrg.1 uc007rrg.2 uc007rrg.3 uc007rrg.4 uc007rrg.5 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation. Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3; Evidence=; Monomer and homodimer. Interacts with COIL (via C-terminus). Nucleus, nucleoplasm cleus, Cajal body Note=Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells. Belongs to the adenylate kinase family. AK6 subfamily. AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species. nucleotide binding adenylate kinase activity ATP binding nucleus nucleoplasm cytoplasm cytosol Cajal body kinase activity phosphorylation transferase activity ATPase activity nucleoside monophosphate phosphorylation nucleolus uc007rrg.1 uc007rrg.2 uc007rrg.3 uc007rrg.4 uc007rrg.5 
ENSMUST00000022136.14 Rad17 ENSMUST00000022136.14 RAD17 checkpoint clamp loader component, transcript variant 1 (from RefSeq NM_011233.3) ENSMUST00000022136.1 ENSMUST00000022136.10 ENSMUST00000022136.11 ENSMUST00000022136.12 ENSMUST00000022136.13 ENSMUST00000022136.2 ENSMUST00000022136.3 ENSMUST00000022136.4 ENSMUST00000022136.5 ENSMUST00000022136.6 ENSMUST00000022136.7 ENSMUST00000022136.8 ENSMUST00000022136.9 NM_011233 O88934 O89024 Q6NXW6 RAD17_MOUSE uc007rrd.1 uc007rrd.2 uc007rrd.3 uc007rrd.4 Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (By similarity). Has a weak ATPase activity required for binding to chromatin (By similarity). Participates in the recruitment of the 9- 1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (By similarity). May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination (PubMed:15297881). Part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Interacts with RAD1 and RAD9 within the 9-1-1 (RAD1-RAD9-HUS1) complex. Interacts with RAD9B, POLE, SNU13 and MCM7. DNA damage promotes interaction with ATR or ATM and disrupts interaction with the 9-1-1 (RAD1-RAD9-HUS1) complex. Nucleus Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage. Ubiquitous at low levels. Highly expressed in testis, where it is expressed in spermatogonia, spermatocytes and spermatids, but absent in mature spermatozoa (at protein level). Phosphorylated. Phosphorylation on Ser-647 and Ser-657 is cell cycle-regulated, enhanced by genotoxic stress, and required for activation of checkpoint signaling (PubMed:11687627, PubMed:14500819, PubMed:17376776). Phosphorylation is mediated by ATR upon UV or replication arrest, whereas it may be mediated both by ATR and ATM upon ionizing radiation (By similarity). Phosphorylation on both sites is required for interaction with RAD1 but dispensable for interaction with RFC3 or RFC4 (By similarity). Mice show numerous defects in embryonic development, starting at E8.5. Belongs to the rad17/RAD24 family. DNA damage checkpoint nucleotide binding chromosome, telomeric region nuclear chromatin chromatin binding DNA clamp loader activity ATP binding nucleus nucleoplasm nucleolus DNA repair cellular response to DNA damage stimulus cell cycle mitotic cell cycle checkpoint multicellular organism development negative regulation of DNA replication Rad17 RFC-like complex mitotic DNA replication checkpoint regulation of phosphorylation uc007rrd.1 uc007rrd.2 uc007rrd.3 uc007rrd.4 
ENSMUST00000022137.14 Marveld2 ENSMUST00000022137.14 MARVEL (membrane-associating) domain containing 2, transcript variant 1 (from RefSeq NM_001038602.4) ENSMUST00000022137.1 ENSMUST00000022137.10 ENSMUST00000022137.11 ENSMUST00000022137.12 ENSMUST00000022137.13 ENSMUST00000022137.2 ENSMUST00000022137.3 ENSMUST00000022137.4 ENSMUST00000022137.5 ENSMUST00000022137.6 ENSMUST00000022137.7 ENSMUST00000022137.8 ENSMUST00000022137.9 MALD2_MOUSE Marveld2 Mrvldc2 NM_001038602 Q3UZP0 Q80UJ4 Q99LE8 Tric uc007rrb.1 uc007rrb.2 uc007rrb.3 Plays a role in the formation of tricellular tight junctions and of epithelial barriers (PubMed:16365161, PubMed:21245199). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:26677943). Interacts with TJP1. Interacts with the ubiquitin ligase ITCH. Interacts (via C-terminal cytoplasmic domain) with LSR (via the cytoplasmic domain), ILDR1 and ILDR2; the interaction is required to recruit MARVELD2 to tricellular contacts (PubMed:21245199, PubMed:23239027). Cell membrane ulti-pass membrane protein Cell junction, tight junction te=Found at tricellular contacts. Detected in small intestine, stomach and kidney, in epithelial cells (PubMed:16365161). Detected in pancreas, retina and lung, and in stria vascularis, utricle and the organ of Conti in the inner ear (at protein level) (PubMed:26677943, PubMed:17186462). Predominantly detected in small intestine, lung and kidney, with lower levels in liver, testis and brain (PubMed:16365161). In colon, expressed in the entire crypts (PubMed:23239027). Phosphorylated. Ubiquitinated by ITCH; but this ubiquitination does not lead to proteasomal degradation. No visible phenotype at birth. Mutant mice have normal gait and equilibrium and are fertile. They display severe and rapidly progressing hearing loss already 14 days after birth, and completely lack response to a 90 dB sound 21 days after birth. Endocochlear potential and paracellular permeability in the stria vascularis are not affected. The arrangement of inner and outer hair cells in the organ of Corti appears normal at 12 days after birth, but outer hair cells and inner hair cells have disappeared by 21 days after birth. Hair cells survive on cochlear explants (in vitro), suggesting that hair cell degeneration is due to K(+) leakage from the endolymph to the perilymph. Belongs to the ELL/occludin family. Sequence=AAH49919.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cytoplasm plasma membrane bicellular tight junction sensory perception of sound membrane integral component of membrane basolateral plasma membrane apical plasma membrane cell junction cytoplasmic vesicle paranodal junction Schmidt-Lanterman incisure cell-cell junction organization establishment of endothelial barrier tricellular tight junction bicellular tight junction assembly uc007rrb.1 uc007rrb.2 uc007rrb.3 
ENSMUST00000022147.15 Smn1 ENSMUST00000022147.15 survival motor neuron 1, transcript variant 1 (from RefSeq NM_011420.2) ENSMUST00000022147.1 ENSMUST00000022147.10 ENSMUST00000022147.11 ENSMUST00000022147.12 ENSMUST00000022147.13 ENSMUST00000022147.14 ENSMUST00000022147.2 ENSMUST00000022147.3 ENSMUST00000022147.4 ENSMUST00000022147.5 ENSMUST00000022147.6 ENSMUST00000022147.7 ENSMUST00000022147.8 ENSMUST00000022147.9 NM_011420 Q549F9 Q549F9_MOUSE Smn Smn1 uc007rqh.1 uc007rqh.2 uc007rqh.3 Cell projection, axon Cell projection, neuron projection Cytoplasm, myofibril, sarcomere, Z line Cytoplasmic granule Nucleus, Cajal body Nucleus, gem Perikaryon Belongs to the SMN family. RNA binding nucleus cytoplasm mRNA processing uc007rqh.1 uc007rqh.2 uc007rqh.3 
ENSMUST00000022148.7 Mccc2 ENSMUST00000022148.7 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) (from RefSeq NM_030026.2) ENSMUST00000022148.1 ENSMUST00000022148.2 ENSMUST00000022148.3 ENSMUST00000022148.4 ENSMUST00000022148.5 ENSMUST00000022148.6 MCCB_MOUSE NM_030026 Q3ULD5 Q3UPS6 uc007rpz.1 uc007rpz.2 uc007rpz.3 Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3- methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate; Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344, ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy- 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3. Probably a dodecamer composed of six biotin-containing alpha subunits (MCCC1) and six beta (MCCC2) subunits. Mitochondrion matrix Belongs to the AccD/PCCB family. nucleotide binding methylcrotonoyl-CoA carboxylase activity ATP binding mitochondrion mitochondrial matrix leucine catabolic process coenzyme A metabolic process ligase activity methylcrotonoyl-CoA carboxylase complex uc007rpz.1 uc007rpz.2 uc007rpz.3 
ENSMUST00000022153.8 Ptcd2 ENSMUST00000022153.8 pentatricopeptide repeat domain 2 (from RefSeq NM_026873.2) ENSMUST00000022153.1 ENSMUST00000022153.2 ENSMUST00000022153.3 ENSMUST00000022153.4 ENSMUST00000022153.5 ENSMUST00000022153.6 ENSMUST00000022153.7 NM_026873 PTCD2_MOUSE Q8R3K3 Q91VG3 Q9D0S7 uc007rpm.1 uc007rpm.2 uc007rpm.3 Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function. Mitochondrion High expression in heart and liver and low expression in kidney, brain and testis. Deficient mice shown deficiency of the third complex of the respiratory chain that caused profound ultrastructural changes in the heart. The outer layers of ventricular cardiomyocytes appeared to be infiltrated with macrovesicular fat deposits, having the appearance of adipocytes. Belongs to the PTCD2 family. Sequence=AAH16563.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential vector sequence.; Evidence=; Sequence=BAB23336.1; Type=Frameshift; Evidence=; kidney development liver development mitochondrion mRNA processing mitochondrion organization multicellular organism development heart development regulation of gene expression muscle fiber development regulation of mRNA processing ventricular cardiac muscle tissue morphogenesis uc007rpm.1 uc007rpm.2 uc007rpm.3 
ENSMUST00000022164.16 Ankra2 ENSMUST00000022164.16 ankyrin repeat family A member 2, transcript variant 4 (from RefSeq NM_023472.2) ANRA2_MOUSE Ankra ENSMUST00000022164.1 ENSMUST00000022164.10 ENSMUST00000022164.11 ENSMUST00000022164.12 ENSMUST00000022164.13 ENSMUST00000022164.14 ENSMUST00000022164.15 ENSMUST00000022164.2 ENSMUST00000022164.3 ENSMUST00000022164.4 ENSMUST00000022164.5 ENSMUST00000022164.6 ENSMUST00000022164.7 ENSMUST00000022164.8 ENSMUST00000022164.9 NM_023472 Q99PE2 uc007ror.1 uc007ror.2 uc007ror.3 uc007ror.4 May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (By similarity). May also regulate LRP2/megalin (PubMed:11095640). Interacts (via ANK repeats) with CCDC8 (via PxLPxI/L motif); mediates the interaction with the 3M complex which is composed of CCDC8, CUL7 and OBSL1. Interacts (via ANK repeats) with HDAC4 (via PxLPxI/L motif). Interacts (via ANK repeats) with HDAC5 (via PxLPxI/L motif) (By similarity). Interacts (via ANK repeats) with LRP2/megalin (via PxLPxI/L motif) (PubMed:11095640). Interacts (via ANK repeats) with RFX7 (via PxLPxI/L motif) (By similarity). Interacts with AHRR (PubMed:17949687). Interacts with NEK6 (By similarity). Cytoplasm, cytoskeleton Membrane ; Peripheral membrane protein The ankyrin repeats, mainly ANK 2, ANK 3 and ANK 4, mediate interaction with a wide array of PxLPxI/L motif-containing proteins including HDAC4 and LRP2. The PxLPxI/L motif of interactors can contain a Ser or a Thr residue in position 2, which phosphorylation prevents the interaction with ANKRA2. protein binding nucleus cytoplasm cytosol cytoskeleton membrane protein kinase binding ubiquitin protein ligase binding macromolecular complex histone deacetylase binding regulation of protein complex assembly low-density lipoprotein particle receptor binding 3M complex uc007ror.1 uc007ror.2 uc007ror.3 uc007ror.4 
ENSMUST00000022169.10 Hexb ENSMUST00000022169.10 hexosaminidase B (from RefSeq NM_010422.2) ENSMUST00000022169.1 ENSMUST00000022169.2 ENSMUST00000022169.3 ENSMUST00000022169.4 ENSMUST00000022169.5 ENSMUST00000022169.6 ENSMUST00000022169.7 ENSMUST00000022169.8 ENSMUST00000022169.9 Hexb NM_010422 Q3TXR9 Q3TXR9_MOUSE uc007roc.1 uc007roc.2 uc007roc.3 Reaction=H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L- iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine = alpha-L-iduronyl- (1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6- sulfogalactosamine; Xref=Rhea:RHEA:64384, ChEBI:CHEBI:15377, ChEBI:CHEBI:152567, ChEBI:CHEBI:152568, ChEBI:CHEBI:153064; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64385; Evidence=; Reaction=H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3- sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = a beta-D- 3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N- acetyl-beta-D-galactosamine; Xref=Rhea:RHEA:48276, ChEBI:CHEBI:15377, ChEBI:CHEBI:28497, ChEBI:CHEBI:90163, ChEBI:CHEBI:90164; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48277; Evidence=; Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52; Evidence= Reaction=beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4- sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O = alpha- L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D- GalNAc-4-sulfate + N-acetyl-D-galactosamine; Xref=Rhea:RHEA:64372, ChEBI:CHEBI:15377, ChEBI:CHEBI:28037, ChEBI:CHEBI:152565, ChEBI:CHEBI:152566; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64373; Evidence=; Reaction=a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine; Xref=Rhea:RHEA:47940, ChEBI:CHEBI:15377, ChEBI:CHEBI:28497, ChEBI:CHEBI:60065, ChEBI:CHEBI:71502; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47941; Evidence=; Reaction=a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D- galactosamine; Xref=Rhea:RHEA:47968, ChEBI:CHEBI:15377, ChEBI:CHEBI:28497, ChEBI:CHEBI:79210, ChEBI:CHEBI:79218; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47969; Evidence=; Cytoplasmic vesicle, secretory vesicle, Cortical granule Lysosome Belongs to the glycosyl hydrolase 20 family. hydrolase activity, hydrolyzing O-glycosyl compounds beta-N-acetylhexosaminidase activity carbohydrate metabolic process metabolic process acetylglucosaminyltransferase activity hydrolase activity hydrolase activity, acting on glycosyl bonds azurophil granule protein homodimerization activity protein heterodimerization activity uc007roc.1 uc007roc.2 uc007roc.3 
ENSMUST00000022170.8 Gfm2 ENSMUST00000022170.8 G elongation factor, mitochondrial 2, transcript variant 5 (from RefSeq NM_001271465.1) B2RR55 ENSMUST00000022170.1 ENSMUST00000022170.2 ENSMUST00000022170.3 ENSMUST00000022170.4 ENSMUST00000022170.5 ENSMUST00000022170.6 ENSMUST00000022170.7 Efg2 NM_001271465 Q8BXS5 Q8R2Q4 RRF2M_MOUSE uc011zdh.1 uc011zdh.2 uc011zdh.3 uc011zdh.4 Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Mitochondrion Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R2Q4-1; Sequence=Displayed; Name=2; IsoId=Q8R2Q4-2; Sequence=VSP_038195; Name=3; IsoId=Q8R2Q4-3; Sequence=VSP_038196; This protein may be expected to contain an N-terminal transit peptide but none has been predicted. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. nucleotide binding translation elongation factor activity GTPase activity GTP binding mitochondrion translation translational elongation mitochondrial translation ribosome disassembly uc011zdh.1 uc011zdh.2 uc011zdh.3 uc011zdh.4 
ENSMUST00000022172.12 Polk ENSMUST00000022172.12 polymerase (DNA directed), kappa, transcript variant 1 (from RefSeq NR_144622.1) Dinb1 ENSMUST00000022172.1 ENSMUST00000022172.10 ENSMUST00000022172.11 ENSMUST00000022172.2 ENSMUST00000022172.3 ENSMUST00000022172.4 ENSMUST00000022172.5 ENSMUST00000022172.6 ENSMUST00000022172.7 ENSMUST00000022172.8 ENSMUST00000022172.9 NR_144622 POLK_MOUSE Q7TPY7 Q9QUG2 uc007rne.1 uc007rne.2 uc007rne.3 DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:12432099). Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity). Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Divalent metal cations. Prefers Mg(2+), but can also use Mn(2+). ; Interacts with PCNA (By similarity). Interacts with REV1 (PubMed:14657033). Nucleus Note=Detected throughout the nucleus and at replication foci. Recruited to DNA damage sites in response to ultraviolet irradiation: N6- methyladenosine (m6A)-containing mRNAs accumulate in the vicinity of DNA damage sites and their presence is required to recruit POLK. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QUG2-1; Sequence=Displayed; Name=2; IsoId=Q9QUG2-2; Sequence=VSP_012807, VSP_012808; Detected at low levels in heart, brain, lung, liver, kidney and testis. The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity. Belongs to the DNA polymerase type-Y family. DNA binding damaged DNA binding DNA-directed DNA polymerase activity protein binding nucleus nucleoplasm DNA replication DNA repair nucleotide-excision repair, DNA gap filling cellular response to DNA damage stimulus nuclear body transferase activity nucleotidyltransferase activity translesion synthesis cellular response to UV error-prone translesion synthesis metal ion binding DNA biosynthetic process uc007rne.1 uc007rne.2 uc007rne.3 
ENSMUST00000022176.15 Hmgcr ENSMUST00000022176.15 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, transcript variant 1 (from RefSeq NM_008255.2) ENSMUST00000022176.1 ENSMUST00000022176.10 ENSMUST00000022176.11 ENSMUST00000022176.12 ENSMUST00000022176.13 ENSMUST00000022176.14 ENSMUST00000022176.2 ENSMUST00000022176.3 ENSMUST00000022176.4 ENSMUST00000022176.5 ENSMUST00000022176.6 ENSMUST00000022176.7 ENSMUST00000022176.8 ENSMUST00000022176.9 G3X8U5 HMDH_MOUSE NM_008255 Q01237 Q5U4I2 uc007rnm.1 uc007rnm.2 uc007rnm.3 uc007rnm.4 uc007rnm.5 Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. Reaction=(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3- methylglutaryl-CoA + 2 H(+) + 2 NADPH; Xref=Rhea:RHEA:15989, ChEBI:CHEBI:15378, ChEBI:CHEBI:36464, ChEBI:CHEBI:43074, ChEBI:CHEBI:57287, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.34; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:15991; Evidence=; Regulated by a negative feedback mechanism through sterols and non-sterol metabolites derived from mevalonate (By similarity). Phosphorylation at Ser-871 down-regulates the catalytic activity (By similarity). Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3. Homotetramer. Homodimer. Interacts (via its SSD) with INSIG1; the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with UBIAD1. Endoplasmic reticulum membrane ; Multi-pass membrane protein Peroxisome membrane ; Multi-pass membrane protein Undergoes sterol-mediated ubiquitination and ER-associated degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1 or INSIG2. The INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78, RNF139 or RNF145, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin- containing protein VCP/p97. The INSIG2-binding leads to the recruitment of the ubiquitin ligase RNF139, initiating ubiquitination of the reductase. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein. N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner. Phosphorylated. Phosphorylation at Ser-871 reduces the catalytic activity. Homozygous knockout mice show early embryonic lethality. Belongs to the HMG-CoA reductase family. hydroxymethylglutaryl-CoA reductase (NADPH) activity peroxisomal membrane endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process ubiquinone metabolic process aging response to nutrient steroid metabolic process cholesterol metabolic process positive regulation of cell proliferation isoprenoid biosynthetic process visual learning negative regulation of striated muscle cell apoptotic process positive regulation of cardiac muscle cell apoptotic process coenzyme A metabolic process membrane integral component of membrane sterol biosynthetic process oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor positive regulation of stress-activated MAPK cascade negative regulation of protein catabolic process hydroxymethylglutaryl-CoA reductase activity protein homodimerization activity negative regulation of apoptotic process intracellular membrane-bounded organelle negative regulation of MAP kinase activity myoblast differentiation response to ethanol positive regulation of skeletal muscle tissue development positive regulation of smooth muscle cell proliferation NADP binding coenzyme binding negative regulation of protein secretion protein tetramerization protein phosphatase 2A binding oxidation-reduction process negative regulation of wound healing negative regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of ERK1 and ERK2 cascade NADPH binding negative regulation of beta-amyloid clearance uc007rnm.1 uc007rnm.2 uc007rnm.3 uc007rnm.4 uc007rnm.5 
ENSMUST00000022182.5 F2rl2 ENSMUST00000022182.5 coagulation factor II thrombin receptor like 2 (from RefSeq NM_010170.4) B9EIT2 ENSMUST00000022182.1 ENSMUST00000022182.2 ENSMUST00000022182.3 ENSMUST00000022182.4 NM_010170 O08675 PAR3_MOUSE Par3 Q3UXV3 uc007rmq.1 uc007rmq.2 uc007rmq.3 High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. Interacts with INSC/inscuteable and GPSM2. Cell membrane; Multi-pass membrane protein. A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway blood coagulation hemostasis thrombin-activated receptor activity membrane integral component of membrane apical plasma membrane macromolecular complex positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway thrombin-activated receptor signaling pathway uc007rmq.1 uc007rmq.2 uc007rmq.3 
ENSMUST00000022185.10 F2rl1 ENSMUST00000022185.10 F2R like trypsin receptor 1 (from RefSeq NM_007974.4) ENSMUST00000022185.1 ENSMUST00000022185.2 ENSMUST00000022185.3 ENSMUST00000022185.4 ENSMUST00000022185.5 ENSMUST00000022185.6 ENSMUST00000022185.7 ENSMUST00000022185.8 ENSMUST00000022185.9 F2rl1 NM_007974 Q3TU81 Q3TU81_MOUSE uc011zda.1 uc011zda.2 uc011zda.3 uc011zda.4 uc011zda.5 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein positive regulation of leukocyte chemotaxis positive regulation of cytokine secretion involved in immune response positive regulation of glomerular filtration G-protein coupled receptor activity early endosome plasma membrane integral component of plasma membrane G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration blood coagulation negative regulation of tumor necrosis factor-mediated signaling pathway thrombin-activated receptor activity membrane integral component of membrane regulation of blood coagulation positive regulation of actin filament depolymerization positive regulation of superoxide anion generation positive regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway positive regulation of Rho protein signal transduction chemokine (C-C motif) ligand 2 secretion neutrophil activation regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of eosinophil degranulation positive regulation of GTPase activity cell-cell junction maintenance positive regulation of transcription from RNA polymerase II promoter regulation of JNK cascade negative regulation of JNK cascade positive regulation of JNK cascade interleukin-1 beta secretion leukocyte migration positive regulation of positive chemotaxis defense response to virus positive regulation of phagocytosis, engulfment establishment of endothelial barrier positive regulation of ERK1 and ERK2 cascade thrombin-activated receptor signaling pathway positive regulation of neutrophil mediated killing of gram-negative bacterium interleukin-10 secretion chemokine secretion negative regulation of chemokine secretion mature conventional dendritic cell differentiation positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion uc011zda.1 uc011zda.2 uc011zda.3 uc011zda.4 uc011zda.5 
ENSMUST00000022186.5 S100z ENSMUST00000022186.5 S100 calcium binding protein, zeta (from RefSeq NM_001081159.1) B9EJL3 B9EJL3_MOUSE ENSMUST00000022186.1 ENSMUST00000022186.2 ENSMUST00000022186.3 ENSMUST00000022186.4 NM_001081159 S100z uc007rml.1 uc007rml.2 uc007rml.3 Belongs to the S-100 family. calcium ion binding cellular_component biological_process protein homodimerization activity metal ion binding uc007rml.1 uc007rml.2 uc007rml.3 
ENSMUST00000022189.9 Aggf1 ENSMUST00000022189.9 angiogenic factor with G patch and FHA domains 1 (from RefSeq NM_025630.3) AGGF1_MOUSE ENSMUST00000022189.1 ENSMUST00000022189.2 ENSMUST00000022189.3 ENSMUST00000022189.4 ENSMUST00000022189.5 ENSMUST00000022189.6 ENSMUST00000022189.7 ENSMUST00000022189.8 NM_025630 Q7TN31 Q8R2S6 Q9CQR9 Q9CU87 Q9D768 Vg5q uc007rmi.1 uc007rmi.2 uc007rmi.3 uc007rmi.4 Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion (By similarity). Interacts with the secreted angiogenic factor TNFSF12. Cytoplasm Secreted Note=Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted (By similarity). Sequence=AAH27286.1; Type=Erroneous initiation; Evidence=; Sequence=AK009533; Type=Frameshift; Evidence=; Sequence=AK017248; Type=Frameshift; Evidence=; angiogenesis positive regulation of endothelial cell proliferation nucleic acid binding extracellular region cytoplasm cell adhesion multicellular organism development cell differentiation positive regulation of angiogenesis perinuclear region of cytoplasm uc007rmi.1 uc007rmi.2 uc007rmi.3 uc007rmi.4 
ENSMUST00000022195.13 Otp ENSMUST00000022195.13 orthopedia homeobox (from RefSeq NM_011021.5) ENSMUST00000022195.1 ENSMUST00000022195.10 ENSMUST00000022195.11 ENSMUST00000022195.12 ENSMUST00000022195.2 ENSMUST00000022195.3 ENSMUST00000022195.4 ENSMUST00000022195.5 ENSMUST00000022195.6 ENSMUST00000022195.7 ENSMUST00000022195.8 ENSMUST00000022195.9 NM_011021 O09113 OTP_MOUSE uc007rly.1 uc007rly.2 uc007rly.3 Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. Nucleus Restricted regions of the developing forebrain, hindbrain, and spinal cord. First detected at 9.5 dpc in restricted domains of the developing diencephalon and along all the hindbrain and the spinal cord. At 10 dpc, found in the medioventral region of the developing spinal cord. At 12.5 dpc, expressed in restricted zones in the preoptic, postoptic and dorsoposterior regions. At later stages, in the intermedial region of the lateral horn, in the optic tract, the presumptive stria terminalis, the amygdaloid complex of the lateral horn in the spinal cord. Death at birth or within the first 2 postnatal days due to defects in neuroendocrine hypothalamus differentiation. Belongs to the paired homeobox family. Bicoid subfamily. positive regulation of neuroblast proliferation DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development nervous system development forebrain neuron differentiation hypothalamus cell differentiation neurohypophysis development cell differentiation sequence-specific DNA binding uc007rly.1 uc007rly.2 uc007rly.3 
ENSMUST00000022196.5 Ap3b1 ENSMUST00000022196.5 adaptor-related protein complex 3, beta 1 subunit (from RefSeq NM_009680.3) AP3B1_MOUSE E9QQ08 ENSMUST00000022196.1 ENSMUST00000022196.2 ENSMUST00000022196.3 ENSMUST00000022196.4 NM_009680 Q91YR4 Q9Z1T1 uc007rlv.1 uc007rlv.2 uc007rlv.3 uc007rlv.4 Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (PubMed:21998198). AP-3 associates with the BLOC-1 complex (PubMed:21998198). Interacts with KIF3A; interaction is direct; interaction is impaired by pyrophosphorylation of AP3B1 (By similarity). Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Ubiquitously expressed. Phosphorylated on serine residues. Pyrophosphorylated by 5-diphosphoinositol pentakisphosphate (5- IP7) (PubMed:17873058). Pyrophosphorylation impairs interaction with KIF3A (By similarity). Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue (PubMed:17873058). Note=Defects in Ap3b1 are the cause of the autosomal recessive phenotype 'pearl' (pe). Pearl mice exhibit hypopigmentation, lysosomal secretion abnormalities, and platelet-dense granules with reduced levels of adenine nucleotides and serotonin. The changes in platelets lead to prolonged bleeding. Additionally, pearl mice exhibit reduced sensitivity in the dark-adapted state (PubMed:9931340). Belongs to the adaptor complexes large subunit family. Golgi apparatus trans-Golgi network protein targeting to lysosome zinc II ion transport intracellular protein transport blood coagulation anterograde axonal transport protein transport membrane synaptic vesicle budding from endosome vesicle-mediated transport antigen processing and presentation protein phosphatase binding membrane coat AP-3 adaptor complex clathrin adaptor complex clathrin-coated vesicle membrane GTP-dependent protein binding cytoplasmic vesicle melanosome organization synapse antigen processing and presentation, exogenous lipid antigen via MHC class Ib anterograde synaptic vesicle transport positive regulation of NK T cell differentiation axon cytoplasm uc007rlv.1 uc007rlv.2 uc007rlv.3 uc007rlv.4 
ENSMUST00000022197.15 Scamp1 ENSMUST00000022197.15 secretory carrier membrane protein 1, transcript variant 1 (from RefSeq NM_029153.1) ENSMUST00000022197.1 ENSMUST00000022197.10 ENSMUST00000022197.11 ENSMUST00000022197.12 ENSMUST00000022197.13 ENSMUST00000022197.14 ENSMUST00000022197.2 ENSMUST00000022197.3 ENSMUST00000022197.4 ENSMUST00000022197.5 ENSMUST00000022197.6 ENSMUST00000022197.7 ENSMUST00000022197.8 ENSMUST00000022197.9 NM_029153 Q8K021 SCAM1_MOUSE uc007rls.1 uc007rls.2 uc007rls.3 Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface (By similarity). Interacts with SYNRG, ITSN1 and SLC9A7. Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Belongs to the SCAMP family. Golgi membrane protein binding endosome Golgi apparatus trans-Golgi network exocytosis endocytosis synaptic vesicle protein transport membrane integral component of membrane protein domain specific binding clathrin-coated vesicle integral component of synaptic vesicle membrane cytoplasmic vesicle membrane synaptic vesicle membrane trans-Golgi network membrane zymogen granule membrane synapse recycling endosome membrane uc007rls.1 uc007rls.2 uc007rls.3 
ENSMUST00000022203.10 Dimt1 ENSMUST00000022203.10 DIM1 rRNA methyltransferase and ribosome maturation factor (from RefSeq NM_025447.4) DIM1_MOUSE Dimt1l ENSMUST00000022203.1 ENSMUST00000022203.2 ENSMUST00000022203.3 ENSMUST00000022203.4 ENSMUST00000022203.5 ENSMUST00000022203.6 ENSMUST00000022203.7 ENSMUST00000022203.8 ENSMUST00000022203.9 NM_025447 Q3TTJ5 Q8BVH8 Q9D0D4 uc007rua.1 uc007rua.2 uc007rua.3 uc007rua.4 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Reaction=adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L- methionine = 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)- dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42780, Rhea:RHEA-COMP:10234, Rhea:RHEA-COMP:10236, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74493; EC=2.1.1.183; Evidence=; Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleoplasm Nucleus, nucleolus Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. Sequence=BAC37166.1; Type=Miscellaneous discrepancy; Note=Introns retention.; Evidence=; rRNA modification rRNA (adenine-N6,N6-)-dimethyltransferase activity RNA binding nucleus nucleoplasm nucleolus mitochondrial matrix cytosol rRNA processing methyltransferase activity rRNA methyltransferase activity transferase activity rRNA methylation methylation 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity positive regulation of rRNA processing uc007rua.1 uc007rua.2 uc007rua.3 uc007rua.4 
ENSMUST00000022204.16 Kif2a ENSMUST00000022204.16 kinesin family member 2A, transcript variant 6 (from RefSeq NM_001378938.1) ENSMUST00000022204.1 ENSMUST00000022204.10 ENSMUST00000022204.11 ENSMUST00000022204.12 ENSMUST00000022204.13 ENSMUST00000022204.14 ENSMUST00000022204.15 ENSMUST00000022204.2 ENSMUST00000022204.3 ENSMUST00000022204.4 ENSMUST00000022204.5 ENSMUST00000022204.6 ENSMUST00000022204.7 ENSMUST00000022204.8 ENSMUST00000022204.9 KIF2A_MOUSE Kif2 Kns2 NM_001378938 O54744 P28740 Q91W03 uc007rud.1 uc007rud.2 uc007rud.3 uc007rud.4 Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity). Interacts with AURKA, PSRC1 and PLK1. Cytoplasm Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, spindle Lysosome Note=Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1 (By similarity). Associated with lysosomes in NIH3T3 cells. Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=P28740-3; Sequence=Displayed; Name=1; Synonyms=Kif2; IsoId=P28740-1; Sequence=VSP_028377, VSP_028379; Name=2; Synonyms=Kif2-beta; IsoId=P28740-2; Sequence=VSP_028377, VSP_028378; Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level). Expressed in the flagellum of elongated spermatids and sperm in the testis lumen (at protein level) (PubMed:24339785). Isoform 1 expressed in neuronal cells. Isoform 2 expressed in astrocytes and fibroblasts. Isoform 1 expressed at low level in 13 dpc embryonic hippocampus, higher level by stage 15 persisting into juvenile and adult stages. Isoform 2 expressed in 13 dpc and 15 dpc embryonic hippocampus declining to very low levels in juvenile and adult neurons. High level of isoform 1 and very low level of isoform 2 in stage 2 and 5 hippocampal neurons in culture. Mice show overextension of collateral branches of developing axons and defects in neuronal migration in the brain. They die within 24 hours of birth. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily. nucleotide binding microtubule cytoskeleton organization spindle pole microtubule motor activity ATP binding nucleus nucleolus cytoplasm lysosome centrosome centriole microtubule organizing center spindle cytoskeleton kinesin complex microtubule spindle microtubule microtubule-based movement cell cycle mitotic spindle organization multicellular organism development nervous system development microtubule binding nuclear body ATPase activity protein kinase binding cell differentiation regulation of cell migration cell division mitotic spindle assembly sperm principal piece uc007rud.1 uc007rud.2 uc007rud.3 uc007rud.4 
ENSMUST00000022207.10 Elovl7 ENSMUST00000022207.10 ELOVL fatty acid elongase 7 (from RefSeq NM_029001.5) ELOV7_MOUSE ENSMUST00000022207.1 ENSMUST00000022207.2 ENSMUST00000022207.3 ENSMUST00000022207.4 ENSMUST00000022207.5 ENSMUST00000022207.6 ENSMUST00000022207.7 ENSMUST00000022207.8 ENSMUST00000022207.9 Elovl7 NM_029001 Q8BX38 Q8BYY8 Q9D2Y9 uc007rva.1 uc007rva.2 uc007rva.3 uc007rva.4 uc007rva.5 Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long- chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=2.3.1.199; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32728; Evidence=; Reaction=eicosanoyl-CoA + H(+) + malonyl-CoA = 3-oxodocosanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35327, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:57384, ChEBI:CHEBI:71451; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35328; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36475, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:57384, ChEBI:CHEBI:73852; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36476; Evidence=; Reaction=(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35379, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57363, ChEBI:CHEBI:57384, ChEBI:CHEBI:71481; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35380; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)- 3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36503, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:57384, ChEBI:CHEBI:74012; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36504; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3- oxoicosenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36511, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:57387, ChEBI:CHEBI:74011; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36512; Evidence=; Reaction=H(+) + malonyl-CoA + octadecanoyl-CoA = 3-oxoeicosanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35319, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:57394, ChEBI:CHEBI:65115; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35320; Evidence=; Reaction=H(+) + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35315, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57384, ChEBI:CHEBI:71407; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35316; Evidence=; Reaction=(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36523, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74034, ChEBI:CHEBI:74054; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36524; Evidence=; Lipid metabolism; fatty acid biosynthesis. Homodimer. Endoplasmic reticulum membrane ; Multi-pass membrane protein The C-terminal di-lysine motif may confer endoplasmic reticulum localization. Belongs to the ELO family. ELOVL7 subfamily. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process fatty acid elongase activity membrane integral component of membrane transferase activity fatty acid elongation, saturated fatty acid sphingolipid biosynthetic process integral component of endoplasmic reticulum membrane fatty acid elongation, monounsaturated fatty acid fatty acid elongation, polyunsaturated fatty acid long-chain fatty-acyl-CoA biosynthetic process very long-chain fatty acid biosynthetic process 3-oxo-arachidoyl-CoA synthase activity 3-oxo-cerotoyl-CoA synthase activity 3-oxo-lignoceronyl-CoA synthase activity uc007rva.1 uc007rva.2 uc007rva.3 uc007rva.4 uc007rva.5 
ENSMUST00000022212.9 Plk2 ENSMUST00000022212.9 polo like kinase 2 (from RefSeq NM_152804.2) ENSMUST00000022212.1 ENSMUST00000022212.2 ENSMUST00000022212.3 ENSMUST00000022212.4 ENSMUST00000022212.5 ENSMUST00000022212.6 ENSMUST00000022212.7 ENSMUST00000022212.8 NM_152804 Plk2 Q548A9 Q548A9_MOUSE Snk uc007rvs.1 uc007rvs.2 uc007rvs.3 uc007rvs.4 uc007rvs.5 Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.21; Evidence=; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. G1/S transition of mitotic cell cycle nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm centrosome centriole protein phosphorylation mitotic spindle organization Ras protein signal transduction positive regulation of autophagy kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation dendrite positive regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process Rap protein signal transduction ATP-dependent protein binding macromolecular complex binding positive regulation of protein catabolic process regulation of centriole replication regulation of synaptic plasticity long-term synaptic potentiation long term synaptic depression negative regulation of dendritic spine development uc007rvs.1 uc007rvs.2 uc007rvs.3 uc007rvs.4 uc007rvs.5 
ENSMUST00000022213.8 Thbs4 ENSMUST00000022213.8 thrombospondin 4 (from RefSeq NM_011582.3) ENSMUST00000022213.1 ENSMUST00000022213.2 ENSMUST00000022213.3 ENSMUST00000022213.4 ENSMUST00000022213.5 ENSMUST00000022213.6 ENSMUST00000022213.7 NM_011582 Q9QYS3 Q9WUE0 Q9Z1T2 TSP4_MOUSE Tsp4 uc007rku.1 uc007rku.2 uc007rku.3 uc007rku.4 Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner. Homopentamer; disulfide-linked. Interacts with PTBP3 (By similarity). Interacts (via EGF-like 3; calcium-binding domain) with ATF6 and facilitates its processing, activation and nuclear translocation. Interacts with NOTCH1. Q9Z1T2; F6VAN0: Atf6; NbExp=3; IntAct=EBI-6171531, EBI-6171558; Endoplasmic reticulum Sarcoplasmic reticulum Secreted Secreted, extracellular space Secreted, extracellular space, extracellular matrix Heart. Up-regulated in the heart in response to ischemic injury and pathology (at protein level). Astrocytes; expressed at high levels in subventricular zone (SVZ)-derived astrocytes and at low levels in cortical astrocytes. In response to peripheral nerve injury, significantly up-regulated in the dorsal spinal cord (at protein level). On exposure to acute pressure overload, mice exhibit a marked increase in: heart weight and fibrosis, cardiomyocyte size and number of apoptotic cells in the myocardium, deposition of extracellular matrix (ECM) and levels of interstitial collagens. The increased ECM deposition is accompanied by changes in functional parameters of the heart and decreased vessel density. Mice also show defective induction of the ER stress response in the heart. Do not exhibit peripheral nerve injury-induced behavioral hypersensitivities such as thermal/mechanical hyperalgesia and tactile allodynia but show severe defects in cortical-injury-induced subventricular zone astrogenesis. Belongs to the thrombospondin family. positive regulation of endothelial cell proliferation fibronectin binding integrin binding extracellular matrix structural constituent calcium ion binding protein binding collagen binding extracellular region basement membrane extracellular space endoplasmic reticulum response to unfolded protein cell adhesion signal transduction nervous system development growth factor activity heparin binding negative regulation of angiogenesis sarcoplasmic reticulum extracellular matrix neuromuscular junction regulation of tissue remodeling response to endoplasmic reticulum stress laminin-1 binding behavioral response to pain tissue remodeling neuron projection morphogenesis positive regulation of peptidyl-tyrosine phosphorylation protein homooligomerization myoblast migration positive regulation of cell division endothelial cell-cell adhesion positive regulation of neutrophil chemotaxis uc007rku.1 uc007rku.2 uc007rku.3 uc007rku.4 
ENSMUST00000022217.9 Zfyve16 ENSMUST00000022217.9 zinc finger, FYVE domain containing 16 (from RefSeq NM_173392.4) ENSMUST00000022217.1 ENSMUST00000022217.2 ENSMUST00000022217.3 ENSMUST00000022217.4 ENSMUST00000022217.5 ENSMUST00000022217.6 ENSMUST00000022217.7 ENSMUST00000022217.8 Kiaa0305 NM_173392 Q80U44 Q8BRD2 Q8CG97 ZFY16_MOUSE uc007rkq.1 uc007rkq.2 uc007rkq.3 uc007rkq.4 May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes (By similarity). Interacts (via C-terminus) with TOM1 (via C-terminus); interaction is required to target TOM1 to endosomes (By similarity). Does not interact with TOM1L1 or TOM1L2 (By similarity). Cytoplasm Early endosome membrane ; Peripheral membrane protein Note=Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P) (By similarity). The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P. Sequence=BAC65523.1; Type=Erroneous initiation; Evidence=; 1-phosphatidylinositol binding phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm endosome early endosome cytosol protein targeting to lysosome membrane endosomal transport early endosome membrane intracellular membrane-bounded organelle metal ion binding uc007rkq.1 uc007rkq.2 uc007rkq.3 uc007rkq.4 
ENSMUST00000022218.6 Dhfr ENSMUST00000022218.6 dihydrofolate reductase (from RefSeq NM_010049.3) Dhfr ENSMUST00000022218.1 ENSMUST00000022218.2 ENSMUST00000022218.3 ENSMUST00000022218.4 ENSMUST00000022218.5 NM_010049 Q544T5 Q544T5_MOUSE uc007rkl.1 uc007rkl.2 uc007rkl.3 Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8- tetrahydrofolate from 7,8-dihydrofolate: step 1/1. Belongs to the dihydrofolate reductase family. dihydrofolate reductase activity cytoplasm mitochondrion axon regeneration response to methotrexate response to nicotine dihydrofolate metabolic process tetrahydrofolate biosynthetic process folic acid metabolic process NADP binding dihydrofolic acid binding oxidation-reduction process uc007rkl.1 uc007rkl.2 uc007rkl.3 
ENSMUST00000022225.12 Trim23 ENSMUST00000022225.12 tripartite motif-containing 23, transcript variant 1 (from RefSeq NM_001361538.1) Arfd1 ENSMUST00000022225.1 ENSMUST00000022225.10 ENSMUST00000022225.11 ENSMUST00000022225.2 ENSMUST00000022225.3 ENSMUST00000022225.4 ENSMUST00000022225.5 ENSMUST00000022225.6 ENSMUST00000022225.7 ENSMUST00000022225.8 ENSMUST00000022225.9 NM_001361538 Q8BGX0 Q8C2B6 Q8CDA4 Q8CDA7 TRI23_MOUSE uc007rsx.1 uc007rsx.2 uc007rsx.3 Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homodimer. Interacts with PSCD1. Interacts with UBE2D2. Interacts with TBK1 (via N-terminal kinase domain) and p62/SQSTM1. Cytoplasm Endomembrane system Golgi apparatus membrane Lysosome membrane Note=Membrane-associated with the Golgi complex and lysosomal structures. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BGX0-1; Sequence=Displayed; Name=2; IsoId=Q8BGX0-2; Sequence=VSP_010814; Name=3; IsoId=Q8BGX0-3; Sequence=VSP_010815; The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity. In the C-terminal section; belongs to the small GTPase superfamily. Arf family. Golgi membrane nucleotide binding nucleic acid binding GTPase activity ubiquitin-protein transferase activity GTP binding nucleus cytoplasm lysosome lysosomal membrane Golgi apparatus plasma membrane protein ADP-ribosylation intracellular protein transport zinc ion binding endomembrane system membrane vesicle-mediated transport protein ubiquitination transferase activity GDP binding identical protein binding metal ion binding uc007rsx.1 uc007rsx.2 uc007rsx.3 
ENSMUST00000022226.6 Ppwd1 ENSMUST00000022226.6 peptidylprolyl isomerase domain and WD repeat containing 1 (from RefSeq NM_172807.4) ENSMUST00000022226.1 ENSMUST00000022226.2 ENSMUST00000022226.3 ENSMUST00000022226.4 ENSMUST00000022226.5 NM_172807 PPWD1_MOUSE Ppwd1 Q0VEA0 Q8CEC6 uc007rsz.1 uc007rsz.2 uc007rsz.3 uc007rsz.4 uc007rsz.5 PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Inhibited by cyclosporin A (CsA). Identified in the spliceosome C complex. Nucleus Note=Associated with spliceosomal complexes. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity nucleus spliceosomal complex mRNA processing RNA splicing cyclosporin A binding nuclear body isomerase activity catalytic step 2 spliceosome uc007rsz.1 uc007rsz.2 uc007rsz.3 uc007rsz.4 uc007rsz.5 
ENSMUST00000022227.8 Cenpk ENSMUST00000022227.8 centromere protein K, transcript variant 1 (from RefSeq NM_021790.2) A0A0R4J037 A0A0R4J037_MOUSE Cenpk ENSMUST00000022227.1 ENSMUST00000022227.2 ENSMUST00000022227.3 ENSMUST00000022227.4 ENSMUST00000022227.5 ENSMUST00000022227.6 ENSMUST00000022227.7 NM_021790 uc007rte.1 uc007rte.2 uc007rte.3 uc007rte.4 Chromosome, centromere Nucleus Belongs to the CENP-K/MCM22 family. nucleus kinetochore assembly uc007rte.1 uc007rte.2 uc007rte.3 uc007rte.4 
ENSMUST00000022228.13 Cwc27 ENSMUST00000022228.13 CWC27 spliceosome-associated protein, transcript variant 1 (from RefSeq NM_026072.1) CWC27_MOUSE Cwc27 ENSMUST00000022228.1 ENSMUST00000022228.10 ENSMUST00000022228.11 ENSMUST00000022228.12 ENSMUST00000022228.2 ENSMUST00000022228.3 ENSMUST00000022228.4 ENSMUST00000022228.5 ENSMUST00000022228.6 ENSMUST00000022228.7 ENSMUST00000022228.8 ENSMUST00000022228.9 NM_026072 Q3TKY6 Q8BG42 Q8R158 Q9CXT1 Sdccag10 uc007rtj.1 uc007rtj.2 uc007rtj.3 As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well- formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex. Component of the minor spliceosome, which splices U12-type introns (By similarity). Nucleus Knockout mice manifest significant embryonic lethality. Growth retardation, lack of neural tube closure, and absence of limb buds are observed at embryonic day 12.5. Surviving mice show growth retardation and retinal dystrophic changes. Belongs to the cyclophilin-type PPIase family. Despite the fact that it belongs to the cyclophilin-type PPIase family, it has probably no peptidyl-prolyl cis-trans isomerase activity. Sequence=AAH25437.1; Type=Erroneous initiation; Evidence=; Sequence=BAB29120.1; Type=Frameshift; Evidence=; Sequence=BAC36042.1; Type=Erroneous initiation; Evidence=; Sequence=BAC37003.1; Type=Erroneous initiation; Evidence=; protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity nucleus nucleoplasm protein folding U2-type precatalytic spliceosome catalytic step 2 spliceosome uc007rtj.1 uc007rtj.2 uc007rtj.3 
ENSMUST00000022230.15 Srek1ip1 ENSMUST00000022230.15 splicing regulatory glutamine/lysine-rich protein 1interacting protein 1, transcript variant 2 (from RefSeq NR_135272.2) ENSMUST00000022230.1 ENSMUST00000022230.10 ENSMUST00000022230.11 ENSMUST00000022230.12 ENSMUST00000022230.13 ENSMUST00000022230.14 ENSMUST00000022230.2 ENSMUST00000022230.3 ENSMUST00000022230.4 ENSMUST00000022230.5 ENSMUST00000022230.6 ENSMUST00000022230.7 ENSMUST00000022230.8 ENSMUST00000022230.9 NR_135272 Q05CD6 Q4V9W2 Q8CGG6 Q9CRM9 Q9CRR4 Q9CXR0 SR1IP_MOUSE Sfrs12ip1 uc007rtm.1 uc007rtm.2 uc007rtm.3 uc007rtm.4 Possible splicing regulator involved in the control of cellular survival. Interacts with SREK1/SFRS12. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q4V9W2-1; Sequence=Displayed; Name=2; IsoId=Q4V9W2-2; Sequence=VSP_029642; Sequence=BAB29157.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAB31175.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; molecular_function nucleic acid binding cellular_component mRNA processing biological_process zinc ion binding RNA splicing metal ion binding uc007rtm.1 uc007rtm.2 uc007rtm.3 uc007rtm.4 
ENSMUST00000022232.6 Nt5el ENSMUST00000022232.6 5' nucleotidase, ecto-like (from RefSeq NM_025751.3) 4933425L06Rik ENSMUST00000022232.1 ENSMUST00000022232.2 ENSMUST00000022232.3 ENSMUST00000022232.4 ENSMUST00000022232.5 NM_025751 Nt5el Q9D3Z8 Q9D3Z8_MOUSE uc007rtq.1 uc007rtq.2 Membrane ; Lipid- anchor, GPI-anchor Belongs to the 5'-nucleotidase family. nucleotide binding molecular_function cellular_component biological_process nucleotide catabolic process hydrolase activity uc007rtq.1 uc007rtq.2 
ENSMUST00000022235.6 Htr1a ENSMUST00000022235.6 5-hydroxytryptamine (serotonin) receptor 1A (from RefSeq NM_008308.5) 5HT1A_MOUSE ENSMUST00000022235.1 ENSMUST00000022235.2 ENSMUST00000022235.3 ENSMUST00000022235.4 ENSMUST00000022235.5 Gpcr18 NM_008308 Q60956 Q61617 Q64264 Q8BGS4 uc007rtu.1 uc007rtu.2 uc007rtu.3 uc007rtu.4 G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. Heterodimer; heterodimerizes with GPER1. Interacts with YIF1B (By similarity). Interacts with GPR39 and GALR1 (By similarity). Cell membrane ; Multi-pass membrane protein Cell projection, dendrite Most abundantly expressed in midbrain, in dorsal raphe and hippocampus. Detected at lower levels in amygdala and brain cortex. Mutant mice display decreased exploratory behavior and increased fear-related behavior in anxiogenic environments. Mutant mice display altered monoamine metabolism in specific parts of the brain, especially in dorsal and medial raphe nuclei, thalamus and hypothalamus, leading to altered levels of 5- hydroxytryptamine, dopamine and their metabolites, as well as altered noradrenaline levels. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily. behavioral fear response G-protein alpha-subunit binding G-protein coupled receptor activity G-protein coupled serotonin receptor activity receptor binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting serotonin receptor signaling pathway serotonin receptor signaling pathway chemical synaptic transmission behavior drug binding cell proliferation regulation of serotonin secretion membrane integral component of membrane dendrite neurotransmitter receptor activity positive regulation of microtubule depolymerization exploration behavior regulation of dopamine metabolic process vasoconstriction serotonin metabolic process neuronal cell body axon hillock regulation of hormone secretion regulation of behavior serotonin binding regulation of feeding behavior receptor-receptor interaction NMDA glutamate receptor clustering GABA-ergic synapse integral component of presynaptic membrane regulation of synaptic vesicle exocytosis uc007rtu.1 uc007rtu.2 uc007rtu.3 uc007rtu.4 
ENSMUST00000022242.9 Emb ENSMUST00000022242.9 embigin (from RefSeq NM_010330.4) EMB_MOUSE ENSMUST00000022242.1 ENSMUST00000022242.2 ENSMUST00000022242.3 ENSMUST00000022242.4 ENSMUST00000022242.5 ENSMUST00000022242.6 ENSMUST00000022242.7 ENSMUST00000022242.8 Gp70 NM_010330 P21995 Q3UFF1 Q8C2J8 Q8C543 Q96C38 uc007rym.1 uc007rym.2 uc007rym.3 uc007rym.4 Plays a role in targeting the monocarboxylate transporters SLC16A1, SLC16A6 and SLC16A7 to the cell membrane (By similarity). Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. Interacts with SLC16A1, SLC16A6 and SLC16A7. Cell membrane ; Single-pass type I membrane protein Synapse Note=Localizes to the neuromuscular junctions. Only member of the immunoglobulin superfamily to be expressed in embryonal carcinoma cells, which resemble multipotential cells of early embryos. At neuromuscular junctions, 5-fold higher expression levels at P0 compared to adult. Regulated by muscle activity. Strongly up-regulated after muscle denervation, including that of gastrocnemius muscle. Maximal expression is observed 10 days after denervation (at protein level). plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules axon guidance membrane integral component of membrane cell junction axon plasma membrane lactate transport synapse dendrite self-avoidance protein binding involved in cell-cell adhesion uc007rym.1 uc007rym.2 uc007rym.3 uc007rym.4 
ENSMUST00000022245.10 Mrps30 ENSMUST00000022245.10 mitochondrial ribosomal protein S30 (from RefSeq NM_021556.3) B2KF79 ENSMUST00000022245.1 ENSMUST00000022245.2 ENSMUST00000022245.3 ENSMUST00000022245.4 ENSMUST00000022245.5 ENSMUST00000022245.6 ENSMUST00000022245.7 ENSMUST00000022245.8 ENSMUST00000022245.9 NM_021556 Q3U9U4 Q9CYS8 Q9D0G0 Q9JJQ2 RT30_MOUSE uc007ryr.1 uc007ryr.2 uc007ryr.3 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mL65 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation biological_process uc007ryr.1 uc007ryr.2 uc007ryr.3 
ENSMUST00000022246.9 Fgf10 ENSMUST00000022246.9 fibroblast growth factor 10 (from RefSeq NM_008002.5) ENSMUST00000022246.1 ENSMUST00000022246.2 ENSMUST00000022246.3 ENSMUST00000022246.4 ENSMUST00000022246.5 ENSMUST00000022246.6 ENSMUST00000022246.7 ENSMUST00000022246.8 FGF10_MOUSE NM_008002 O35565 Q543V5 uc007ryv.1 uc007ryv.2 uc007ryv.3 uc007ryv.4 Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 (By similarity). Secreted Expressed abundantly in embryos and the lung, and at much lower levels in brain and heart. Belongs to the heparin-binding growth factors family. establishment of mitotic spindle orientation activation of MAPK activity angiogenesis metanephros development organ induction mesonephros development blood vessel remodeling metanephros morphogenesis fibroblast growth factor receptor binding type 2 fibroblast growth factor receptor binding protein binding extracellular region extracellular space nucleus plasma membrane chemotaxis cell-cell signaling determination of left/right symmetry salivary gland development salivary gland morphogenesis growth factor activity heparin binding positive regulation of cell proliferation negative regulation of cell proliferation fibroblast growth factor receptor signaling pathway epidermis development regulation of smoothened signaling pathway embryonic pattern specification animal organ morphogenesis cell surface regulation of gene expression positive regulation of epithelial cell migration positive regulation of keratinocyte proliferation response to organic cyclic compound pituitary gland development cell differentiation positive regulation of Wnt signaling pathway lung development embryonic genitalia morphogenesis epithelial cell differentiation thyroid gland development otic vesicle formation positive regulation of vascular endothelial growth factor receptor signaling pathway pancreas development hair follicle morphogenesis embryonic camera-type eye development actin cytoskeleton reorganization response to estradiol response to lipopolysaccharide positive regulation of ATPase activity lacrimal gland development regulation of activin receptor signaling pathway protein localization to cell surface somatic stem cell population maintenance limb morphogenesis organ growth chemoattractant activity wound healing tissue regeneration inner ear morphogenesis odontogenesis of dentin-containing tooth muscle cell fate commitment positive regulation of MAPK cascade negative regulation of cell differentiation positive regulation of DNA repair positive regulation of DNA replication positive regulation of Notch signaling pathway positive regulation of transcription, DNA-templated positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of Ras protein signal transduction regulation of saliva secretion positive regulation of fibroblast proliferation lung alveolus development blood vessel morphogenesis spleen development thymus development embryonic digestive tract morphogenesis digestive tract development embryonic digestive tract development animal organ formation epidermis morphogenesis semicircular canal morphogenesis branching morphogenesis of an epithelial tube female genitalia morphogenesis male genitalia morphogenesis positive regulation of lymphocyte proliferation epithelial cell proliferation urothelial cell proliferation positive regulation of urothelial cell proliferation positive regulation of epithelial cell proliferation positive regulation of peptidyl-tyrosine phosphorylation white fat cell differentiation positive chemotaxis induction of positive chemotaxis smooth muscle cell differentiation positive regulation of keratinocyte migration radial glial cell differentiation limb development limb bud formation lung morphogenesis lung epithelium development lung saccule development bronchiole morphogenesis epithelial tube branching involved in lung morphogenesis branching involved in salivary gland morphogenesis bud outgrowth involved in lung branching bud elongation involved in lung branching mesenchymal-epithelial cell signaling involved in lung development Type II pneumocyte differentiation prostatic bud formation respiratory system development mammary gland specification fibroblast growth factor receptor signaling pathway involved in mammary gland specification mammary gland bud formation submandibular salivary gland formation epithelial cell proliferation involved in salivary gland morphogenesis regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling branch elongation involved in salivary gland morphogenesis semicircular canal fusion mesenchymal cell differentiation involved in lung development secretion by lung epithelial cell involved in lung growth lung proximal/distal axis specification tear secretion positive regulation of white fat cell proliferation ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade Harderian gland development negative regulation of cell cycle arrest positive regulation of hair follicle cell proliferation positive regulation of canonical Wnt signaling pathway positive regulation of G1/S transition of mitotic cell cycle negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc007ryv.1 uc007ryv.2 uc007ryv.3 uc007ryv.4 
ENSMUST00000022256.5 Psmd6 ENSMUST00000022256.5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 (from RefSeq NM_025550.3) ENSMUST00000022256.1 ENSMUST00000022256.2 ENSMUST00000022256.3 ENSMUST00000022256.4 NM_025550 PSMD6_MOUSE Q99JI4 Q9CWZ1 uc007sgj.1 uc007sgj.2 uc007sgj.3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD6, a base containing 6 ATPases and few additional components. Belongs to the proteasome subunit S10 family. proteasome complex proteasome regulatory particle proteasome accessory complex enzyme regulator activity proteasome-mediated ubiquitin-dependent protein catabolic process regulation of catalytic activity uc007sgj.1 uc007sgj.2 uc007sgj.3 
ENSMUST00000022262.6 Fezf2 ENSMUST00000022262.6 Fez family zinc finger 2 (from RefSeq NM_080433.3) ENSMUST00000022262.1 ENSMUST00000022262.2 ENSMUST00000022262.3 ENSMUST00000022262.4 ENSMUST00000022262.5 FEZF2_MOUSE Fez Fezl NM_080433 Q9D298 Q9ESP5 Zfp312 uc007sfs.1 uc007sfs.2 uc007sfs.3 uc007sfs.4 Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Nucleus Highly expressed in neocortical layer V, moderately expressed in layer VI. Expressed in subcortically projecting neurons. Expressed in the olfactory epithelium, hypothalamus, ventrolateral pallium and prethalamus at mid-gestation. At 12.5 dpc, highly enriched in the postmigratory pyramidal neurons forming the cortical plate situated beneath the pial surface. At 13.5 dpc, expressed in the ventricular zone and subventricular zone at low levels, expression is much higher in the developing cortical plate, where postmitotic neurons are positioned. During late embryonic and early postnatal development, expression disappears from cortical progenitors and becomes restricted to the subplate and the prospective layer V and VI pyramidal neurons. In null mutant mice, no subcerebral projection neurons are born and no cortical projections to the brainstem or the spinal cord ever develop. In contrast, other populations of neurons are unaffected. There seems to be a redundant role for FEZF1 and FEZF2 in diencephalon development. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development nervous system development axonal fasciculation locomotory behavior negative regulation of cell proliferation dendrite development telencephalon development dentate gyrus development forebrain anterior/posterior pattern specification cerebral cortex GABAergic interneuron migration cerebral cortex neuron differentiation commitment of neuronal cell to specific neuron type in forebrain cell differentiation forebrain development sequence-specific DNA binding cell dedifferentiation transcription regulatory region DNA binding negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding neuron fate determination regulation of neurogenesis regulation of axon guidance uc007sfs.1 uc007sfs.2 uc007sfs.3 uc007sfs.4 
ENSMUST00000022268.10 Pdhb ENSMUST00000022268.10 pyruvate dehydrogenase (lipoamide) beta (from RefSeq NM_024221.3) ENSMUST00000022268.1 ENSMUST00000022268.2 ENSMUST00000022268.3 ENSMUST00000022268.4 ENSMUST00000022268.5 ENSMUST00000022268.6 ENSMUST00000022268.7 ENSMUST00000022268.8 ENSMUST00000022268.9 NM_024221 ODPB_MOUSE Q3TL86 Q505N8 Q99LW9 Q9D051 uc007sev.1 uc007sev.2 uc007sev.3 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Reaction=H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate = CO2 + N(6)-[(R)-S(8)- acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase]; Xref=Rhea:RHEA:19189, Rhea:RHEA-COMP:10480, Rhea:RHEA-COMP:10481, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:83099, ChEBI:CHEBI:83111; EC=1.2.4.1; Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Heterotetramer of two PDHA1 and two PDHB subunits. The heterotetramer interacts with DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules. Interacts with DLAT. Mitochondrion matrix Sequence=AAH02188.1; Type=Erroneous initiation; Evidence=; catalytic activity pyruvate dehydrogenase activity pyruvate dehydrogenase (acetyl-transferring) activity nucleoplasm mitochondrion mitochondrial matrix carbohydrate metabolic process glucose metabolic process acetyl-CoA biosynthetic process from pyruvate tricarboxylic acid cycle oxidoreductase activity pyruvate dehydrogenase (NAD+) activity pyruvate dehydrogenase complex oxidation-reduction process mitochondrial acetyl-CoA biosynthetic process from pyruvate uc007sev.1 uc007sev.2 uc007sev.3 
ENSMUST00000022269.7 Fam3d ENSMUST00000022269.7 FAM3 metabolism regulating signaling molecule D (from RefSeq NM_146050.2) ENSMUST00000022269.1 ENSMUST00000022269.2 ENSMUST00000022269.3 ENSMUST00000022269.4 ENSMUST00000022269.5 ENSMUST00000022269.6 FAM3D_MOUSE Fam3d NM_146050 Oit1 P97805 Q8R009 Q8R1F2 uc007sfd.1 uc007sfd.2 uc007sfd.3 Secreted Belongs to the FAM3 family. molecular_function cellular_component extracellular region negative regulation of insulin secretion negative regulation of glucagon secretion uc007sfd.1 uc007sfd.2 uc007sfd.3 
ENSMUST00000022275.14 Ankrd55 ENSMUST00000022275.14 ankyrin repeat domain 55, transcript variant 1 (from RefSeq NM_029898.3) ANR55_MOUSE E9QPX4 ENSMUST00000022275.1 ENSMUST00000022275.10 ENSMUST00000022275.11 ENSMUST00000022275.12 ENSMUST00000022275.13 ENSMUST00000022275.2 ENSMUST00000022275.3 ENSMUST00000022275.4 ENSMUST00000022275.5 ENSMUST00000022275.6 ENSMUST00000022275.7 ENSMUST00000022275.8 ENSMUST00000022275.9 NM_029898 Q3UUM0 Q8BLD6 Q9CTM6 uc007rwd.1 uc007rwd.2 uc007rwd.3 uc007rwd.4 molecular_function cellular_component biological_process uc007rwd.1 uc007rwd.2 uc007rwd.3 uc007rwd.4 
ENSMUST00000022281.5 Mtrex ENSMUST00000022281.5 Mtr4 exosome RNA helicase (from RefSeq NM_028151.2) ENSMUST00000022281.1 ENSMUST00000022281.2 ENSMUST00000022281.3 ENSMUST00000022281.4 MTREX_MOUSE Mtrex NM_028151 Q9CZU3 Skiv2l2 uc007rws.1 uc007rws.2 uc007rws.3 Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension. Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand. Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (By similarity). Plays a role in DNA damage response (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Activated when MTREX is incorporated into NEXT complex an the nuclear RNA exosome complex. Component of a TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Identified in the spliceosome C complex. Component of the poly(A) tail exosome targeting (PAXT) complex made of PABPN1, ZFC3H1 and MTREX that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. Component of the nuclear exosome targeting (NEXT) complex composed of MTREX, ZCCHC8, and RBM7 that directs a subset of non-coding short-lived RNAs for exosomal degradation. Interacts with ZCCHC8; this interaction bridges the interaction between RBM7 and MTREX. Binds to ZFC3H1 and RBM7 in a RNase-insensitive manner. Interacts with EXOSC10; the interaction mediates the association of MTREX with nuclear RNA exosomes. Interacts with isoform 1 of NVL in an ATP-dependent manner; the interaction is required to associate NVL with nuclear RNA exosome. Interacts with WDR74; the interaction dissociation in a late stage of rRNA synthesis is required for appropriate maturation of pre-60S particles and depends on the ATPase activity of NVL. Interacts with MPHOSPH6. Interacts with the RNA cap-binding complex proteins NCBP1 and SRRT. Interacts with NRDE2; the interaction is direct and negatively regulates MTREX function in exosomal degradation by changing its conformation precluding interaction with ZFC3H1, the RNA cap-binding complex proteins NCBP1 and SRRT, and association with the exosome. Interacts with the nuclear RNA exosome complex. Nucleus, nucleoplasm Nucleus, nucleolus Nucleus Nucleus speckle Belongs to the helicase family. SKI2 subfamily. nucleotide binding nuclear exosome (RNase complex) exosome (RNase complex) maturation of 5.8S rRNA nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus nucleoplasm spliceosomal complex nucleolus rRNA processing mRNA processing RNA catabolic process RNA splicing hydrolase activity TRAMP complex catalytic step 2 spliceosome uc007rws.1 uc007rws.2 uc007rws.3 
ENSMUST00000022282.6 Gpx8 ENSMUST00000022282.6 glutathione peroxidase 8 (putative), transcript variant 1 (from RefSeq NM_027127.3) ENSMUST00000022282.1 ENSMUST00000022282.2 ENSMUST00000022282.3 ENSMUST00000022282.4 ENSMUST00000022282.5 GPX8_MOUSE NM_027127 Q8VE68 Q9D7B7 uc007rxb.1 uc007rxb.2 uc007rxb.3 Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; Membrane ; Single-pass membrane protein Belongs to the glutathione peroxidase family. peroxidase activity glutathione peroxidase activity cellular_component response to oxidative stress membrane integral component of membrane oxidoreductase activity oxidation-reduction process cellular oxidant detoxification uc007rxb.1 uc007rxb.2 uc007rxb.3 
ENSMUST00000022286.8 Ndufs4 ENSMUST00000022286.8 NADH:ubiquinone oxidoreductase core subunit S4 (from RefSeq NM_010887.2) E9QPX3 E9QPX3_MOUSE ENSMUST00000022286.1 ENSMUST00000022286.2 ENSMUST00000022286.3 ENSMUST00000022286.4 ENSMUST00000022286.5 ENSMUST00000022286.6 ENSMUST00000022286.7 NM_010887 Ndufs4 uc007rxm.1 uc007rxm.2 uc007rxm.3 uc007rxm.4 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the complex I NDUFS4 subunit family. regulation of protein phosphorylation mitochondrion mitochondrial respiratory chain complex I brain development NADH dehydrogenase (ubiquinone) activity oxidoreductase activity, acting on NAD(P)H cAMP-mediated signaling electron transport chain mitochondrial respiratory chain complex I assembly cellular respiration positive regulation of fibroblast proliferation response to cAMP reactive oxygen species metabolic process uc007rxm.1 uc007rxm.2 uc007rxm.3 uc007rxm.4 
ENSMUST00000022296.7 Ube2e1 ENSMUST00000022296.7 ubiquitin-conjugating enzyme E2E 1 (from RefSeq NM_009455.3) ENSMUST00000022296.1 ENSMUST00000022296.2 ENSMUST00000022296.3 ENSMUST00000022296.4 ENSMUST00000022296.5 ENSMUST00000022296.6 NM_009455 Q541Z5 Q541Z5_MOUSE Ube2e1 uc007shu.1 uc007shu.2 uc007shu.3 Belongs to the ubiquitin-conjugating enzyme family. ubiquitin ligase complex nucleotide binding protein polyubiquitination ubiquitin-protein transferase activity ATP binding nucleus histone monoubiquitination protein ubiquitination transferase activity ISG15-protein conjugation histone H2B ubiquitination ISG15 transferase activity ubiquitin conjugating enzyme activity protein K48-linked ubiquitination uc007shu.1 uc007shu.2 uc007shu.3 
ENSMUST00000022304.12 Thrb ENSMUST00000022304.12 thyroid hormone receptor beta, transcript variant 2 (from RefSeq NM_009380.3) ENSMUST00000022304.1 ENSMUST00000022304.10 ENSMUST00000022304.11 ENSMUST00000022304.2 ENSMUST00000022304.3 ENSMUST00000022304.4 ENSMUST00000022304.5 ENSMUST00000022304.6 ENSMUST00000022304.7 ENSMUST00000022304.8 ENSMUST00000022304.9 Erba2 NM_009380 Nr1a2 P37242 P37244 Q0VDR8 Q3TY80 THB_MOUSE uc007sho.1 uc007sho.2 uc007sho.3 uc007sho.4 Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with the coactivators NCOA1/SRC1, NCOA2/GRIP1, NCOA7 and MED1/TRAP220 in a ligand-inducible manner. Interacts with the corepressor NCOR1 in absence of ligand (By similarity). Interacts with C1D. Interacts with NR2F6; the interaction impairs the binding of the THRB homodimer and THRB:RXRB heterodimer to T3 response elements. Interacts with PRMT2 and THRSP (By similarity). Interacts with TACC1; this interaction is decreased in the presence of thyroid hormone T3 (By similarity). P37242; O08915: Aip; NbExp=2; IntAct=EBI-6935043, EBI-6935014; Nucleus. Event=Alternative splicing; Named isoforms=2; Name=Beta-1; IsoId=P37242-1; Sequence=Displayed; Name=Beta-2; IsoId=P37242-2, P37244-1; Sequence=VSP_031078; Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Belongs to the nuclear hormone receptor family. NR1 subfamily. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding thyroid hormone mediated signaling pathway DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development sensory perception of sound negative regulation of female receptivity regulation of heart contraction female courtship behavior transcription factor binding zinc ion binding positive regulation of cell proliferation hormone-mediated signaling pathway animal organ morphogenesis nuclear body regulation of lipid metabolic process enzyme binding cell differentiation ligand-dependent nuclear receptor transcription coactivator activity thyroid gland development chromatin DNA binding positive regulation of chondrocyte differentiation response to lipid signaling receptor activity negative regulation of eye photoreceptor cell development protein homodimerization activity steroid hormone mediated signaling pathway sequence-specific DNA binding positive regulation of ossification negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinal cone cell development metal ion binding Type I pneumocyte differentiation thyroid hormone binding regulation of cholesterol metabolic process regulation of triglyceride metabolic process RNA polymerase II transcription factor complex retinal cone cell apoptotic process nuclear chromatin uc007sho.1 uc007sho.2 uc007sho.3 uc007sho.4 
ENSMUST00000022310.7 Ngly1 ENSMUST00000022310.7 N-glycanase 1, transcript variant 1 (from RefSeq NM_021504.3) ENSMUST00000022310.1 ENSMUST00000022310.2 ENSMUST00000022310.3 ENSMUST00000022310.4 ENSMUST00000022310.5 ENSMUST00000022310.6 NGLY1_MOUSE NM_021504 Q8K113 Q9CTK3 Q9JI78 uc007sgz.1 uc007sgz.2 uc007sgz.3 Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. Reaction=Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue.; EC=3.5.1.52; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Inhibited by Z-VAD-fmk, a well-known caspase inhibitor, which inhibits enzyme activity through covalent binding of the carbohydrate to the single Cys-306 residue. Kinetic parameters: KM=114 uM for fetuin glycopeptide I ; Vmax=0.0964 nmol/min/mg enzyme with fetuin glycopeptide I as substrate ; Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with the proteasome components RAD23B and PSMC1. Interacts with directly with VCP. Interacts with DERL1, bringing it close to the endoplasmic reticulum membrane. Interacts with SAKS1. Q9JI78; Q9R049: Amfr; NbExp=5; IntAct=EBI-3648128, EBI-3648125; Q9JI78; Q01853: Vcp; NbExp=9; IntAct=EBI-3648128, EBI-80597; Q9JI78; P54725: RAD23A; Xeno; NbExp=2; IntAct=EBI-3648128, EBI-746453; Cytoplasm Ubiquitously expressed with highest level in testis. The PUB domain mediates the interaction with VCP. Belongs to the transglutaminase-like superfamily. PNGase family. peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity protein binding nucleus cytoplasm cytosol misfolded or incompletely synthesized protein catabolic process glycoprotein catabolic process protein deglycosylation hydrolase activity metal ion binding uc007sgz.1 uc007sgz.2 uc007sgz.3 
ENSMUST00000022311.12 Oxsm ENSMUST00000022311.12 3-oxoacyl-ACP synthase, mitochondrial, transcript variant 1 (from RefSeq NM_027695.4) ENSMUST00000022311.1 ENSMUST00000022311.10 ENSMUST00000022311.11 ENSMUST00000022311.2 ENSMUST00000022311.3 ENSMUST00000022311.4 ENSMUST00000022311.5 ENSMUST00000022311.6 ENSMUST00000022311.7 ENSMUST00000022311.8 ENSMUST00000022311.9 NM_027695 OXSM_MOUSE Oxsm Q9D404 uc007sgx.1 uc007sgx.2 uc007sgx.3 May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Reaction=a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:22836, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:9916, Rhea:RHEA-COMP:14125, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78776, ChEBI:CHEBI:138651; EC=2.3.1.41; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22837; Evidence=; Reaction=butanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41820, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9628, Rhea:RHEA-COMP:9629, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78454, ChEBI:CHEBI:78456; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41821; Evidence=; Reaction=H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41836, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9632, Rhea:RHEA-COMP:9633, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78459, ChEBI:CHEBI:78460; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41837; Evidence=; Reaction=H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41852, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9636, Rhea:RHEA-COMP:9637, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78463, ChEBI:CHEBI:78464; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41853; Evidence=; Reaction=decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41868, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9640, Rhea:RHEA-COMP:9641, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78468, ChEBI:CHEBI:78469; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41869; Evidence=; Reaction=dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl- [ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41884, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9644, Rhea:RHEA-COMP:9645, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:65264, ChEBI:CHEBI:78449, ChEBI:CHEBI:78473; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41885; Evidence=; Reaction=H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3- oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41900, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9648, Rhea:RHEA-COMP:9649, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78477, ChEBI:CHEBI:78478; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41901; Evidence=; Inhibited by cerulenin. Lipid metabolism; fatty acid biosynthesis. Mitochondrion Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. catalytic activity 3-oxoacyl-[acyl-carrier-protein] synthase activity mitochondrion cytosol lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process acyl-CoA metabolic process transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups short-chain fatty acid biosynthetic process medium-chain fatty acid biosynthetic process uc007sgx.1 uc007sgx.2 uc007sgx.3 
ENSMUST00000022316.6 Dydc2 ENSMUST00000022316.6 DPY30 domain containing 2, transcript variant 1 (from RefSeq NM_027717.3) Dydc2 ENSMUST00000022316.1 ENSMUST00000022316.2 ENSMUST00000022316.3 ENSMUST00000022316.4 ENSMUST00000022316.5 NM_027717 Q9D3X8 Q9D3X8_MOUSE uc007tck.1 uc007tck.2 uc007tck.3 Belongs to the dpy-30 family. MLL3/4 complex Set1C/COMPASS complex histone H3-K4 methylation uc007tck.1 uc007tck.2 uc007tck.3 
ENSMUST00000022322.17 Glud1 ENSMUST00000022322.17 glutamate dehydrogenase 1 (from RefSeq NM_008133.4) DHE3_MOUSE ENSMUST00000022322.1 ENSMUST00000022322.10 ENSMUST00000022322.11 ENSMUST00000022322.12 ENSMUST00000022322.13 ENSMUST00000022322.14 ENSMUST00000022322.15 ENSMUST00000022322.16 ENSMUST00000022322.2 ENSMUST00000022322.3 ENSMUST00000022322.4 ENSMUST00000022322.5 ENSMUST00000022322.6 ENSMUST00000022322.7 ENSMUST00000022322.8 ENSMUST00000022322.9 Glud NM_008133 P26443 Q8C273 uc007tas.1 uc007tas.2 uc007tas.3 uc007tas.4 Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate (PubMed:20670938). Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). Plays a role in insulin homeostasis (PubMed:16959573). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). Reaction=H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+); Xref=Rhea:RHEA:15133, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16810, ChEBI:CHEBI:28938, ChEBI:CHEBI:29985, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.4.1.3; Evidence=; Reaction=H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+); Xref=Rhea:RHEA:11612, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16810, ChEBI:CHEBI:28938, ChEBI:CHEBI:29985, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.4.1.3; Evidence=; Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP. ADP can occupy the NADH binding site and activate the enzyme. Inhibited by SIRT4 (By similarity). Inhibited by HADH (PubMed:20670938). Kinetic parameters: KM=107 uM for 2-oxoglutarate ; Homohexamer (By similarity). Interacts with HADH; this interaction inhibits the activation of GLUD1 (PubMed:20670938). Mitochondrion Endoplasmic reticulum Note=Mostly translocates into the mitochondria, only a small amount of the protein localizes to the endoplasmic reticulum. Acetylation of Lys-84 is observed in liver mitochondria from fasted mice but not from fed mice. ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity (PubMed:16959573). Stoichiometry shows that ADP- ribosylation occurs in one subunit per catalytically active homohexamer (By similarity). Belongs to the Glu/Leu/Phe/Val dehydrogenases family. nucleotide binding glutamate dehydrogenase (NAD+) activity glutamate dehydrogenase [NAD(P)+] activity protein binding ATP binding GTP binding cytoplasm mitochondrion mitochondrial inner membrane mitochondrial matrix cellular amino acid metabolic process glutamate biosynthetic process glutamate catabolic process glutamine metabolic process long-term memory response to aluminum ion oxidoreductase activity oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor enzyme binding cerebellum development positive regulation of insulin secretion ADP binding oxidation-reduction process NAD+ binding leucine binding tricarboxylic acid metabolic process uc007tas.1 uc007tas.2 uc007tas.3 uc007tas.4 
ENSMUST00000022325.3 9230112D13Rik ENSMUST00000022325.3 RIKEN cDNA 9230112D13 gene (from RefSeq NM_030062.1) 9230112D13Rik ENSMUST00000022325.1 ENSMUST00000022325.2 NM_030062 Q9D260 Q9D260_MOUSE uc007tay.1 uc007tay.2 molecular_function cellular_component biological_process uc007tay.1 uc007tay.2 
ENSMUST00000022328.14 Ldb3 ENSMUST00000022328.14 LIM domain binding 3, transcript variant 2 (from RefSeq NM_001039071.2) B2RSB0 B7ZNT6 ENSMUST00000022328.1 ENSMUST00000022328.10 ENSMUST00000022328.11 ENSMUST00000022328.12 ENSMUST00000022328.13 ENSMUST00000022328.2 ENSMUST00000022328.3 ENSMUST00000022328.4 ENSMUST00000022328.5 ENSMUST00000022328.6 ENSMUST00000022328.7 ENSMUST00000022328.8 ENSMUST00000022328.9 Kiaa0613 LDB3_MOUSE Ldb3 NM_001039071 Q6A038 Q811P2 Q811P3 Q811P4 Q811P5 Q9D130 Q9JKS3 Q9JKS4 Q9R0Z1 Q9WVH1 Q9WVH2 uc007tbd.1 uc007tbd.2 uc007tbd.3 May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. Interacts via its LIM domains with various PKC isoforms. Interacts via its PDZ domain with the ACTN2 C-terminal region. Interacts with MYOZ1, MYOZ2 and MYOZ3. Cytoplasm, perinuclear region Cell projection, pseudopodium Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line Note=Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines. Event=Alternative splicing; Named isoforms=6; Name=1 ; Synonyms=Cypher1c , Oracle 1 ; IsoId=Q9JKS4-1; Sequence=Displayed; Name=2 ; Synonyms=Cypher1s ; IsoId=Q9JKS4-2; Sequence=VSP_051903; Name=3 ; Synonyms=Cypher3c , Oracle 2 ; IsoId=Q9JKS4-3; Sequence=VSP_051904; Name=4 ; Synonyms=Cypher3s ; IsoId=Q9JKS4-4; Sequence=VSP_051903, VSP_051904; Name=5 ; Synonyms=Cypher2c ; IsoId=Q9JKS4-5; Sequence=VSP_051905, VSP_051906; Name=6 ; Synonyms=Cypher2s ; IsoId=Q9JKS4-6; Sequence=VSP_051903, VSP_051905, VSP_051906; Expressed primarily in adult heart and skeletal muscle, and detected at lower levels in lung. Isoforms are expressed in a tissue-specific manner. Isoform 1, isoform 3 and isoform 5 are expressed in heart, whereas isoform 2, isoform 4 and isoform 6 are expressed in skeletal muscle. Initially expressed in a myocardium-specific manner at 8.5-9 dpc and remains cardiac-restricted until day 12. Strongly expressed throughout heart in all stages examined. At 12.5 dpc expressed at low levels in non-cardiac striated muscles. By 14.5 dpc expressed at high levels in both cardiac and skeletal muscle, and also strongly expressed in striated muscles of tongue, thoracic and abdominal muscles, leg and diaphragm. The various isoforms are developmentally regulated in both skeletal and cardiac muscle. Isoform 5 and isoform 6, which are barely detectable during embryogenesis are up-regulated postnatally. In heart, isoform 3 is up-regulated developmentally, whereas the predominant isoform 1 is expressed throughout development and into adulthood. In skeletal muscle, the predominant isoform 2 is gradually replaced by isoform 4 postnatally. Sequence=BAB23128.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence=; Sequence=BAD32258.1; Type=Erroneous initiation; Evidence=; stress fiber actin binding protein kinase C binding protein binding cytoplasm cytoskeleton cell-cell adherens junction heart development cytoskeletal protein binding Z disc actin cytoskeleton organization pseudopodium filamentous actin cell projection sarcomere organization metal ion binding perinuclear region of cytoplasm muscle alpha-actinin binding muscle structure development uc007tbd.1 uc007tbd.2 uc007tbd.3 
ENSMUST00000022331.3 Opn4 ENSMUST00000022331.3 opsin 4 (melanopsin), transcript variant 1 (from RefSeq NM_013887.2) A4QPG3 B2C712 ENSMUST00000022331.1 ENSMUST00000022331.2 Mop Mopn NM_013887 OPN4_MOUSE Q9QXZ9 uc007tbh.1 uc007tbh.2 uc007tbh.3 Photoreceptor that binds cis-retinaldehydes (PubMed:19793992). Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light (PubMed:12808468). May be involved in the optokinetic visual tracking response (PubMed:26392540). May be involved in the regulation of retinal hyaloid vessel growth and regression (PubMed:30936473). Cell membrane ; Multi-pass membrane protein Cell projection, axon Cell projection, dendrite Perikaryon Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Opn4L; IsoId=Q9QXZ9-1; Sequence=Displayed; Name=2; Synonyms=Opn4S; IsoId=Q9QXZ9-2; Sequence=VSP_045928; Expressed in the retinal pigment epithelium and ganglion cell layer (at protein level) (PubMed:10632589, PubMed:30240620, PubMed:31607531). Also expressed in amacrine cell layers of the retina (PubMed:10632589). Weakly expressed in vibrissae, and tail (PubMed:31607531). [Isoform 1]: Observed with processes in the outer strata of inner plexiform layer (IPL) close to the inner nuclear layer (INL) or is found to be bistratified with processes located both in the inner (ON) or outer (OFF) layers of the IPL (at protein level) (PubMed:19793992). A second population of isoform 1 is identified in processes which are confined to the inner layer of the IPL near to the ganglion cell layer (GCL) (at protein level) (PubMed:19793992). [Isoform 2]: About 40 times more abundant than isoform 1 in the retina (at protein level) (PubMed:19793992). Isoform 2 is involved in processes localized to the outer IPL or is bistratified with processes in both the inner and outer layers of the IPL (at protein level) (PubMed:19793992). Isoform 2 is absent in the processes confined only to the inner layer of the IPL (at protein level) (PubMed:19793992). Expressed in the inner retina at postnatal day 5 (P5), and expressed in retinal ganglion cells at P12. Mice fail to show a pupillar reflex, photoentrainment of the circadian clock and other non-image forming responses to light (PubMed:12808468). Newborn mice show normal hyaloid vessel numbers and normal vessel cellularity, however vessel numbers are increased by P8 (PubMed:30936473). In Opn4 and Pde6b double knockout mice optokinetic visual tracking response is abolished (PubMed:26392540). Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. G-protein coupled receptor activity 11-cis retinal binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway visual perception phototransduction G-protein coupled photoreceptor activity detection of visible light photoreceptor activity membrane integral component of membrane rhodopsin mediated signaling pathway protein-chromophore linkage regulation of circadian rhythm entrainment of circadian clock by photoperiod positive regulation of circadian sleep/wake cycle, sleep rhythmic process response to stimulus cellular response to light stimulus uc007tbh.1 uc007tbh.2 uc007tbh.3 
ENSMUST00000022337.11 Cdhr1 ENSMUST00000022337.11 cadherin-related family member 1 (from RefSeq NM_130878.3) CDHR1_MOUSE ENSMUST00000022337.1 ENSMUST00000022337.10 ENSMUST00000022337.2 ENSMUST00000022337.3 ENSMUST00000022337.4 ENSMUST00000022337.5 ENSMUST00000022337.6 ENSMUST00000022337.7 ENSMUST00000022337.8 ENSMUST00000022337.9 Kiaa1775 NM_130878 Pcdh21 Prcad Q8CFQ4 Q8CH99 Q8VHP6 uc007tbu.1 uc007tbu.2 uc007tbu.3 Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells. Interacts with PROM1. Q8VHP6; O43490: PROM1; Xeno; NbExp=3; IntAct=EBI-4395045, EBI-3447549; Cell membrane ; Single-pass membrane protein Note=Localized at the junction between the inner and outer segments of rod and cone photoreceptors cells. Confined to the base of the OS. Localized on the edges of nascent evaginating disks on the side of the OS opposite the connecting cilium. Expressed at postnatal day 2 at the apical tip of the rod photoreceptor cells, the site of the developing OS. Colocalized with rhodopsin between postnatal days 2 and 9 at the base of the growing OS region. Expressed in cone and rod photoreceptor cells (at protein level). Expressed in photoreceptor cells of the outer nuclear layer of the retina. Expressed in mitral and tufted cells in the olfactory bulb. Undergoes proteolytic cleavage; produces a soluble 95 kDa N- terminal fragment and a 25 kDa cell-associated C-terminal fragment. Mice have no obvious phenotype but show photoreceptor cell death as early as 1 month of age shortly after completion of retinal development. Its absence severely compromises the structure of OS which are disorganized and fragmented, but the consequences on photoreceptor electrical signaling are very mild. Proteolytic cleavage is partially inhibited in the absence of orderly OS assembly in mouse retinas lacking RDS/peripherin. Sequence=BAC41482.1; Type=Miscellaneous discrepancy; Note=Partially unspliced pre-RNA.; Evidence=; calcium ion binding protein binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules photoreceptor cell morphogenesis cellular process membrane integral component of membrane photoreceptor cell outer segment organization photoreceptor outer segment membrane photoreceptor cell maintenance uc007tbu.1 uc007tbu.2 uc007tbu.3 
ENSMUST00000022338.7 Rgr ENSMUST00000022338.7 retinal G protein coupled receptor, transcript variant 1 (from RefSeq NM_021340.4) ENSMUST00000022338.1 ENSMUST00000022338.2 ENSMUST00000022338.3 ENSMUST00000022338.4 ENSMUST00000022338.5 ENSMUST00000022338.6 NM_021340 Q9Z2B3 RGR_MOUSE uc007tbq.1 uc007tbq.2 uc007tbq.3 uc007tbq.4 The gene is a member of the opsin family of G-protein coupled receptors. The encoded protein is expressed in the retina, and acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Disruption of a similar gene in human is associated with autosomal recessive (arRP) and autosomal dominant retinitis pigmentosa (adRP). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism (By similarity). Membrane; Multi-pass membrane protein. Covalently binds all-trans- and 11-cis-retinal. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. photoreceptor outer segment G-protein coupled receptor activity integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway visual perception phototransduction G-protein coupled photoreceptor activity detection of visible light photoreceptor activity membrane integral component of membrane protein-chromophore linkage response to stimulus cellular response to light stimulus uc007tbq.1 uc007tbq.2 uc007tbq.3 uc007tbq.4 
ENSMUST00000022340.5 Nid2 ENSMUST00000022340.5 nidogen 2 (from RefSeq NM_008695.2) ENSMUST00000022340.1 ENSMUST00000022340.2 ENSMUST00000022340.3 ENSMUST00000022340.4 NID2_MOUSE NM_008695 O88322 Q7TQF0 uc007siu.1 uc007siu.2 uc007siu.3 Cell adhesion glycoprotein. Might be involved in osteoblast differentiation. It probably has a role in cell-extracellular matrix interactions. Interacts with LAMA2. Interacts with COL13A1 (By similarity). Interacts with EFEMP2 (PubMed:17324935). Secreted, extracellular space, extracellular matrix, basement membrane. Highly N- and O-glycosylated. extracellular matrix structural constituent calcium ion binding protein binding extracellular region basement membrane extracellular space plasma membrane cell adhesion cell-matrix adhesion cell surface extracellular matrix uc007siu.1 uc007siu.2 uc007siu.3 
ENSMUST00000022341.7 Rtraf ENSMUST00000022341.7 RNA transcription, translation and transport factor (from RefSeq NM_026528.3) ENSMUST00000022341.1 ENSMUST00000022341.2 ENSMUST00000022341.3 ENSMUST00000022341.4 ENSMUST00000022341.5 ENSMUST00000022341.6 NM_026528 Q9CQE8 RTRAF RTRAF_MOUSE uc007siv.1 uc007siv.2 uc007siv.3 RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and is required for tRNA ligation. May be required for RNA transport. Homodimer. Interacts with FAM98A (via N- and C-terminus). Interacts with NIN; which may prevent phosphorylation of NIN. Interacts with POLR2A. Component of a tRNA-splicing ligase complex. Nucleus Cytoplasm, cytosol Cytoplasm, perinuclear region Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=May localize at the centrosome during mitosis. Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (By similarity). Belongs to the RTRAF family. RNA polymerase II core binding RNA binding nucleus nucleoplasm cytoplasm centrosome microtubule organizing center cytosol cytoskeleton tRNA splicing, via endonucleolytic cleavage and ligation negative regulation of protein kinase activity identical protein binding positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm tRNA-splicing ligase complex mitotic spindle uc007siv.1 uc007siv.2 uc007siv.3 
ENSMUST00000022343.6 Nudt13 ENSMUST00000022343.6 nudix hydrolase 13, transcript variant 2 (from RefSeq NM_026341.3) ENSMUST00000022343.1 ENSMUST00000022343.2 ENSMUST00000022343.3 ENSMUST00000022343.4 ENSMUST00000022343.5 NM_026341 NUD13_MOUSE Nudt13 Q8JZU0 Q9CXN4 uc007sjb.1 uc007sjb.2 uc007sjb.3 NAD(P)H pyrophosphatase that hydrolyzes NADH into NMNH and AMP, and NADPH into NMNH and 2',5'-ADP (PubMed:28755312). Has a marked preference for the reduced pyridine nucleotides (PubMed:28755312). Does not show activity toward NAD-capped RNAs; the NAD-cap is an atypical cap present at the 5'-end of some RNAs (PubMed:31101919). Reaction=H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D- ribonucleotide; Xref=Rhea:RHEA:48868, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57945, ChEBI:CHEBI:90832, ChEBI:CHEBI:456215; EC=3.6.1.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48869; Evidence=; Reaction=H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+); Xref=Rhea:RHEA:11800, ChEBI:CHEBI:14649, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:456215; EC=3.6.1.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11801; Evidence=; Reaction=H2O + NADPH = adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide; Xref=Rhea:RHEA:60820, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:90832, ChEBI:CHEBI:194156; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60821; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Divalent metal cations. Mg(2+) or Mn(2+). ; Kinetic parameters: KM=0.34 mM for NADH ; Note=kcat is 7 sec(-1) for NADH. ; pH dependence: Optimum pH is 7.8-8.2. ; Mitochondrion Belongs to the Nudix hydrolase family. Sequence=AAH37091.1; Type=Erroneous initiation; Evidence=; Sequence=BAB29203.1; Type=Erroneous initiation; Evidence=; mitochondrion biological_process hydrolase activity metal ion binding uc007sjb.1 uc007sjb.2 uc007sjb.3 
ENSMUST00000022344.4 Ecd ENSMUST00000022344.4 ecdysoneless cell cycle regulator (from RefSeq NM_027475.3) ECD_MOUSE ENSMUST00000022344.1 ENSMUST00000022344.2 ENSMUST00000022344.3 NM_027475 Q9CS74 uc011zgo.1 uc011zgo.2 uc011zgo.3 Regulator of p53/TP53 stability and function. Inhibits MDM2- mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (By similarity). Involved in regulation of cell cycle progression (PubMed:26711270). Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing (By similarity). Interacts with TP53, MDM2, TXNIP. Interacts (phosphorylated) with PIH1D1. Interacts with RUVBL1 mediating the PIH1D1-independent association with the R2TP complex. Interacts with RB1, RBL1 and RBL2; ECD competes with E2F1 for binding to hypophospshorylated RB1. Interacts with EP300. Q9CS74; Q9R000: Itgb1bp2; NbExp=2; IntAct=EBI-7922565, EBI-7922331; Cytoplasm. Nucleus Phosphorylated predominantly by CK2 on two serine-containing clusters; involved in cell cycle regulation activity. Embryonic lethal. Belongs to the ECD family. protein binding nucleus nucleoplasm cytoplasm cytosol mRNA processing cell proliferation RNA splicing histone acetyltransferase binding positive regulation of transcription from RNA polymerase II promoter regulation of G1/S transition of mitotic cell cycle uc011zgo.1 uc011zgo.2 uc011zgo.3 
ENSMUST00000022345.7 Dnajc9 ENSMUST00000022345.7 DnaJ heat shock protein family (Hsp40) member C9 (from RefSeq NM_134081.5) DNJC9_MOUSE ENSMUST00000022345.1 ENSMUST00000022345.2 ENSMUST00000022345.3 ENSMUST00000022345.4 ENSMUST00000022345.5 ENSMUST00000022345.6 NM_134081 Q3TSG3 Q8R0E3 Q91WN1 uc007sjn.1 uc007sjn.2 uc007sjn.3 Acts as a dual histone chaperone and heat shock co-chaperone (By similarity). As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes (By similarity). May also act as a histone co-chaperone together with TONSL (By similarity). May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers (By similarity). Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8 (By similarity). As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity (By similarity). Exhibits activity to assemble histones onto DNA in vitro (By similarity). Forms a co-chaperone complex with MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts (via C-terminus) with MCM2 (via N-terminus); the interaction is histone-dependent (By similarity). Within the complex, interacts (via C-terminus) with histone H3.3-H4 heterodimers; the interaction is direct (By similarity). Interacts with histones H4, H3.3, H3.2 and H3.1, but not with CENPA or the testis-specific histone H3.1t (By similarity). Interacts (via J domain) with HSPA1A, HSPA1B and HSPA8 (By similarity). May interact with TONSL; the interaction seems to be histone-dependent (By similarity). May interact with HSPA8 and BAG2; the interactions seem to be histone-dependent (By similarity). Nucleus Cytoplasm Cell membrane Note=Predominantly nuclear. Translocates to the cytoplasm and membrane after heat shock. The functional J domain is required for the release from histone-dependent chromatin-binding. extracellular space nucleus nucleoplasm cytoplasm cytosol plasma membrane membrane heat shock protein binding positive regulation of ATPase activity uc007sjn.1 uc007sjn.2 uc007sjn.3 
ENSMUST00000022349.14 Cfap70 ENSMUST00000022349.14 cilia and flagella associated protein 70, transcript variant 1 (from RefSeq NM_001163638.1) B7ZNG2 B7ZNG3 CFA70_MOUSE Cfap70 D3YVL2 D3Z1K9 E9Q7X8 ENSMUST00000022349.1 ENSMUST00000022349.10 ENSMUST00000022349.11 ENSMUST00000022349.12 ENSMUST00000022349.13 ENSMUST00000022349.2 ENSMUST00000022349.3 ENSMUST00000022349.4 ENSMUST00000022349.5 ENSMUST00000022349.6 ENSMUST00000022349.7 ENSMUST00000022349.8 ENSMUST00000022349.9 NM_001163638 Ttc18 uc011zgq.1 uc011zgq.2 uc011zgq.3 Axoneme-binding protein that plays a role in the regulation of ciliary motility and cilium length. Cell projection, cilium, flagellum Cytoplasm, cytoskeleton, flagellum basal body Cell projection, cilium Cytoplasm, cytoskeleton, cilium axoneme Note=Present all along the flagellum, with a marked signal at the base of the flagellum. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=D3YVL2-1; Sequence=Displayed; Name=2; IsoId=D3YVL2-2; Sequence=VSP_060550; Name=3; IsoId=D3YVL2-3; Sequence=VSP_060549, VSP_060551; Detected in ependyma, trachea, lung, testis, and oviduct, but not in whole brain, liver, kidney, and spleen (PubMed:30158508). Localizes on the epithelial cilia and sperm flagella (at protein level) (PubMed:30158508). The conserved TPR domains are dispensable for ciliary targeting. The N-terminal half is important for cilary localization and/or binding to the axoneme. Belongs to the CFAP70 family. molecular_function biological_process uc011zgq.1 uc011zgq.2 uc011zgq.3 
ENSMUST00000022353.5 Mss51 ENSMUST00000022353.5 MSS51 mitochondrial translational activator (from RefSeq NM_029104.1) ENSMUST00000022353.1 ENSMUST00000022353.2 ENSMUST00000022353.3 ENSMUST00000022353.4 MSS51_MOUSE NM_029104 Q0VD61 Q9D5Z5 Zmynd17 uc007sjw.1 uc007sjw.2 uc007sjw.3 uc007sjw.4 Although no clear MSS51 ortholog is encoded in mammalian genomes, the mammalian MSS51/ZMYND17 protein is significantly similar. Considered by a number of resources to be the ortholog of yeast MSS51. molecular_function cellular_component biological_process metal ion binding uc007sjw.1 uc007sjw.2 uc007sjw.3 uc007sjw.4 
ENSMUST00000022356.12 Usp54 ENSMUST00000022356.12 ubiquitin specific peptidase 54, transcript variant 7 (from RefSeq NR_175348.1) ENSMUST00000022356.1 ENSMUST00000022356.10 ENSMUST00000022356.11 ENSMUST00000022356.2 ENSMUST00000022356.3 ENSMUST00000022356.4 ENSMUST00000022356.5 ENSMUST00000022356.6 ENSMUST00000022356.7 ENSMUST00000022356.8 ENSMUST00000022356.9 NR_175348 Q149D8 Q149D9 Q6NZE1 Q8BL06 Q8BZ28 Q9D2I9 UBP54_MOUSE uc288rgu.1 uc288rgu.2 Has no peptidase activity. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BL06-1; Sequence=Displayed; Name=2; IsoId=Q8BL06-2; Sequence=VSP_020488, VSP_035679, VSP_035680; Name=3; IsoId=Q8BL06-3; Sequence=VSP_035679, VSP_035680; Belongs to the peptidase C19 family. Although the active site residues are conserved, lacks the conserved His residue which is normally found 9 residues before the catalytic His. Sequence=AAI17845.1; Type=Erroneous initiation; Evidence=; Sequence=AAI17846.1; Type=Erroneous initiation; Evidence=; Sequence=BAB31805.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process protein deubiquitination thiol-dependent ubiquitinyl hydrolase activity uc288rgu.1 uc288rgu.2 
ENSMUST00000022358.9 Zswim8 ENSMUST00000022358.9 zinc finger SWIM-type containing 8, transcript variant 1 (from RefSeq NM_027996.4) B2RX90 ENSMUST00000022358.1 ENSMUST00000022358.2 ENSMUST00000022358.3 ENSMUST00000022358.4 ENSMUST00000022358.5 ENSMUST00000022358.6 ENSMUST00000022358.7 ENSMUST00000022358.8 Kiaa0913 NM_027996 Q3UHH1 Q5U4B9 Q6PCY6 Q80Y41 Q8CE12 Q8CHC3 Q9D789 ZSWM8_MOUSE Zswim8 uc007sko.1 uc007sko.2 uc007sko.3 Substrate recognition component of a SCF-like E3 ubiquitin- protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (By similarity). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (By similarity). May also acts as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (By similarity). Protein modification; protein ubiquitination. Component of the SCF-like E3 ubiquitin-protein ligase complex which contains CUL3, RBX1, ELOB, ELOC and ZSWIM8. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q3UHH1-1; Sequence=Displayed; Name=2; IsoId=Q3UHH1-2; Sequence=VSP_029595; Name=3; IsoId=Q3UHH1-3; Sequence=VSP_029598; Name=4; IsoId=Q3UHH1-4; Sequence=VSP_029592, VSP_029599, VSP_029600; Name=5; IsoId=Q3UHH1-5; Sequence=VSP_029593, VSP_029594, VSP_029596, VSP_029597; Belongs to the ZSWIM8 family. Sequence=BAB26298.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cytosol zinc ion binding Cul2-RING ubiquitin ligase complex metal ion binding regulation of axon guidance uc007sko.1 uc007sko.2 uc007sko.3 
ENSMUST00000022368.4 Plau ENSMUST00000022368.4 plasminogen activator, urokinase (from RefSeq NM_008873.3) ENSMUST00000022368.1 ENSMUST00000022368.2 ENSMUST00000022368.3 NM_008873 Plau Q0VBA8 Q0VBA8_MOUSE uc007skx.1 uc007skx.2 uc007skx.3 uc007skx.4 Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Reaction=Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.; EC=3.4.21.73; Evidence=; Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity cell surface regulation of receptor activity regulation of smooth muscle cell migration kinase activity phosphorylation hydrolase activity positive regulation of cell migration plasminogen activation regulation of cell adhesion mediated by integrin regulation of smooth muscle cell-matrix adhesion uc007skx.1 uc007skx.2 uc007skx.3 uc007skx.4 
ENSMUST00000022369.9 Vcl ENSMUST00000022369.9 vinculin (from RefSeq NM_009502.5) ENSMUST00000022369.1 ENSMUST00000022369.2 ENSMUST00000022369.3 ENSMUST00000022369.4 ENSMUST00000022369.5 ENSMUST00000022369.6 ENSMUST00000022369.7 ENSMUST00000022369.8 NM_009502 Q64727 Q8BP32 Q8BS46 Q922C5 Q922D9 VINC_MOUSE uc007skz.1 uc007skz.2 uc007skz.3 Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity). Exhibits self-association properties. Part of a complex composed of THSD1, PTK2/FAK1, TLN1 and VCL (By similarity). Interacts with APBB1IP, NRAP and TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin (By similarity). Interacts with SORBS1 (PubMed:10085297). Interacts with SYNM (By similarity). Interacts with CTNNA1 (By similarity). Binds to ACTN4; this interaction triggers conformational changes (By similarity). Q64727; Q61210: Arhgef1; NbExp=3; IntAct=EBI-432047, EBI-641821; Q64727; Q8VI36: Pxn; NbExp=3; IntAct=EBI-432047, EBI-983394; Q64727; P39447: Tjp1; NbExp=8; IntAct=EBI-432047, EBI-79508; Q64727; P26039: Tln1; NbExp=2; IntAct=EBI-432047, EBI-1039593; Q64727; P49024: PXN; Xeno; NbExp=4; IntAct=EBI-432047, EBI-2896280; Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell junction, adherens junction Cell junction, focal adhesion Cytoplasm, cytoskeleton Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side Cell projection, podosome Note=Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions. Exists in at least two conformations. When in the closed, 'inactive' conformation, extensive interactions between the head and tail domains prevent detectable binding to most of its ligands. It takes on an 'active' conformation after cooperative and simultaneous binding of two different ligands. This activation involves displacement of the head-tail interactions and leads to a significant accumulation of ternary complexes. The active form then binds a number of proteins that have both signaling and structural roles that are essential for cell adhesion. The N-terminal globular head (Vh) comprises of subdomains D1- D4. The C-terminal tail (Vt) binds F-actin and cross-links actin filaments into bundles. An intramolecular interaction between Vh and Vt masks the F-actin-binding domain located in Vt. The binding of talin and alpha-actinin to the D1 subdomain of vinculin induces a helical bundle conversion of this subdomain, leading to the disruption of the intramolecular interaction and the exposure of the cryptic F-actin- binding domain of Vt. Vt inhibits actin filament barbed end elongation without affecting the critical concentration of actin assembly. Phosphorylated; on serines, threonines and tyrosines. Phosphorylation on Tyr-1065 in activated platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor on localization to focal adhesion plaques (By similarity). Acetylated; mainly by myristic acid but also by a small amount of palmitic acid. Belongs to the vinculin/alpha-catenin family. morphogenesis of an epithelium podosome dystroglycan binding actin binding structural molecule activity protein binding cytoplasm cytoskeleton plasma membrane brush border cell-cell junction adherens junction cell-cell adherens junction zonula adherens fascia adherens focal adhesion cell adhesion intercalated disc actin cytoskeleton membrane Rho GTPase binding Z disc lamellipodium assembly cell junction regulation of cell migration ubiquitin protein ligase binding macromolecular complex adherens junction assembly protein localization to cell surface sarcolemma costamere apical junction assembly membrane raft alpha-catenin binding axon extension actin filament binding epithelial cell-cell adhesion outer dense plaque of desmosome inner dense plaque of desmosome terminal web stress fiber actin filament uc007skz.1 uc007skz.2 uc007skz.3 
ENSMUST00000022377.11 Txndc16 ENSMUST00000022377.11 thioredoxin domain containing 16, transcript variant 2 (from RefSeq NM_172597.3) ENSMUST00000022377.1 ENSMUST00000022377.10 ENSMUST00000022377.2 ENSMUST00000022377.3 ENSMUST00000022377.4 ENSMUST00000022377.5 ENSMUST00000022377.6 ENSMUST00000022377.7 ENSMUST00000022377.8 ENSMUST00000022377.9 Kiaa1344 NM_172597 Q69ZL5 Q7TN22 Q8BL40 Q8R2W8 Q9CS82 TXD16_MOUSE Txndc16 uc007tge.1 uc007tge.2 uc007tge.3 Secreted Endoplasmic reticulum lumen Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TN22-1; Sequence=Displayed; Name=2; IsoId=Q7TN22-2; Sequence=VSP_021364; Contains a masked and non-functional KDEL endoplasmic reticulum retrieval motif. Glycosylated. Sequence=BAD32431.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function extracellular region endoplasmic reticulum endoplasmic reticulum lumen biological_process cell redox homeostasis uc007tge.1 uc007tge.2 uc007tge.3 
ENSMUST00000022378.9 Ero1a ENSMUST00000022378.9 endoplasmic reticulum oxidoreductase 1 alpha (from RefSeq NM_015774.3) ENSMUST00000022378.1 ENSMUST00000022378.2 ENSMUST00000022378.3 ENSMUST00000022378.4 ENSMUST00000022378.5 ENSMUST00000022378.6 ENSMUST00000022378.7 ENSMUST00000022378.8 ERO1A_MOUSE Ero1a Ero1l NM_015774 Q8R180 Q9CV47 Q9QY03 uc007tgm.1 uc007tgm.2 uc007tgm.3 This gene encodes a member of the endoplasmic reticulum oxidoreductin family. The encoded protein is localized to the endoplasmic reticulum and promotes the formation of disulfide bonds by oxidizing protein disulfide isomerase. This gene may play a role in endoplasmic reticulum stress-induced apoptosis and the cellular response to hypoxia. [provided by RefSeq, Feb 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.36336.1, AK142595.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins (By similarity). Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Enzyme activity is tightly regulated to prevent the accumulation of reactive oxygen species in the endoplasmic reticulum. Reversibly down-regulated by the formation of disulfide bonds between the active site Cys-94 and Cys-130, and between Cys-99 and Cys-104. Glutathione may be required to regulate its activity in the endoplasmic reticulum (By similarity). Predominantly monomer. May function both as a monomer and a homodimer. Interacts with PDILT. Interacts with ERP44; the interaction results in retention of ERO1A in the endoplasmic reticulum. Endoplasmic reticulum membrane ; Peripheral membrane protein ; Lumenal side Golgi apparatus lumen Secreted Cell projection, dendrite Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum (By similarity). In neurons, it localizes to dendrites (By similarity). Widely expressed (at protein level) (PubMed:20308425). In the mammary gland, expressed at higher levels in lactating mice than in virgin mice (at protein level) (PubMed:29858230). Stimulated by hypoxia; suggesting that it is regulated via the HIF-pathway. By ER stress in a DDIT3/CHOP-dependent manner. N-glycosylated. The Cys-94/Cys-99 and Cys-390/Cys-393 disulfide bonds constitute the redox-active center. The Cys-94/Cys-99 disulfide bond may accept electron from P4HB and funnel them to the active site disulfide Cys- 390/Cys-393. The regulatory Cys-99/Cys-104 disulfide bond stabilizes the other regulatory bond Cys-94/Cys-130 (By similarity). Phosphorylated on Ser-144 by FAM20C in the Golgi which increases its enzymatic activity (By similarity). Phosphorylation is induced by lactation (PubMed:29858230). It is also induced by hypoxia and reductive stress (By similarity). Belongs to the EROs family. protein disulfide isomerase activity endoplasmic reticulum endoplasmic reticulum membrane protein folding apoptotic process animal organ senescence protein disulfide oxidoreductase activity membrane oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor 4-hydroxyproline metabolic process protein maturation by protein folding integral component of endoplasmic reticulum membrane extracellular matrix organization dendrite endoplasmic reticulum unfolded protein response protein folding in endoplasmic reticulum response to endoplasmic reticulum stress cell redox homeostasis brown fat cell differentiation chaperone mediated protein folding requiring cofactor release of sequestered calcium ion into cytosol oxidation-reduction process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to hypoxia uc007tgm.1 uc007tgm.2 uc007tgm.3 
ENSMUST00000022380.9 Psmc6 ENSMUST00000022380.9 proteasome (prosome, macropain) 26S subunit, ATPase, 6, transcript variant 1 (from RefSeq NM_025959.4) ENSMUST00000022380.1 ENSMUST00000022380.2 ENSMUST00000022380.3 ENSMUST00000022380.4 ENSMUST00000022380.5 ENSMUST00000022380.6 ENSMUST00000022380.7 ENSMUST00000022380.8 NM_025959 Psmc6 Q14AQ1 Q14AQ1_MOUSE uc007tgn.1 uc007tgn.2 uc007tgn.3 Belongs to the AAA ATPase family. nucleotide binding proteasome complex ATP binding cytoplasm proteasome regulatory particle, base subcomplex inclusion body hydrolase activity ATPase activity protein catabolic process ER-associated ubiquitin-dependent protein catabolic process cytosolic proteasome complex positive regulation of inclusion body assembly uc007tgn.1 uc007tgn.2 uc007tgn.3 
ENSMUST00000022386.15 Samd4 ENSMUST00000022386.15 sterile alpha motif domain containing 4, transcript variant 1 (from RefSeq NM_001037221.2) A6H6C5 ENSMUST00000022386.1 ENSMUST00000022386.10 ENSMUST00000022386.11 ENSMUST00000022386.12 ENSMUST00000022386.13 ENSMUST00000022386.14 ENSMUST00000022386.2 ENSMUST00000022386.3 ENSMUST00000022386.4 ENSMUST00000022386.5 ENSMUST00000022386.6 ENSMUST00000022386.7 ENSMUST00000022386.8 ENSMUST00000022386.9 NM_001037221 Q2VA55 Q3TQA5 Q3TTN7 Q3UZ00 Q8CBY1 Q9D3T3 SMAG1_MOUSE Samd4a Smaug1 uc007thn.1 uc007thn.2 uc007thn.3 uc007thn.4 Acts as a translational repressor of SRE-containing messengers. Cytoplasm Cell projection, dendrite Synapse, synaptosome Note=Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs, PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (By similarity). Enriched in synaptoneurosomes. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8CBY1-1; Sequence=Displayed; Name=2; IsoId=Q8CBY1-2; Sequence=VSP_037782; Name=3; IsoId=Q8CBY1-3; Sequence=VSP_037783; Name=4; IsoId=Q8CBY1-4; Sequence=VSP_037781; Expressed in brain (at protein level). Belongs to the SMAUG family. Sequence=ABB83932.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; nuclear-transcribed mRNA poly(A) tail shortening P-body fibrillar center RNA binding mRNA binding cytoplasm cytosol regulation of translation negative regulation of translation cell junction translation repressor activity dendrite cell projection neuron projection regulation of mRNA stability synapse positive regulation of translation uc007thn.1 uc007thn.2 uc007thn.3 uc007thn.4 
ENSMUST00000022416.15 Anxa11 ENSMUST00000022416.15 annexin A11 (from RefSeq NM_013469.2) ANX11_MOUSE Anx11 ENSMUST00000022416.1 ENSMUST00000022416.10 ENSMUST00000022416.11 ENSMUST00000022416.12 ENSMUST00000022416.13 ENSMUST00000022416.14 ENSMUST00000022416.2 ENSMUST00000022416.3 ENSMUST00000022416.4 ENSMUST00000022416.5 ENSMUST00000022416.6 ENSMUST00000022416.7 ENSMUST00000022416.8 ENSMUST00000022416.9 NM_013469 P97384 Q921F1 uc007srv.1 uc007srv.2 uc007srv.3 uc007srv.4 Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner. Interacts with S100A6. Interacts with PDCD6 in a calcium- dependent manner. Interacts with KIF23 during cytokinesis. Cytoplasm Melanosome Nucleus envelope Nucleus, nucleoplasm Cytoplasm, cytoskeleton, spindle Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus. Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. A pair of annexin repeats may form one binding site for calcium and phospholipid. Belongs to the annexin family. calcium ion binding calcium-dependent phospholipid binding nucleus nuclear envelope nucleoplasm cytoplasm spindle cytosol cytoskeleton phagocytosis cell cycle phosphatidylethanolamine binding midbody cytokinetic process melanosome specific granule azurophil granule S100 protein binding phagocytic vesicle calcium-dependent protein binding cell division response to calcium ion uc007srv.1 uc007srv.2 uc007srv.3 uc007srv.4 
ENSMUST00000022419.7 Ppif ENSMUST00000022419.7 peptidylprolyl isomerase F (cyclophilin F) (from RefSeq NM_134084.1) ENSMUST00000022419.1 ENSMUST00000022419.2 ENSMUST00000022419.3 ENSMUST00000022419.4 ENSMUST00000022419.5 ENSMUST00000022419.6 NM_134084 PPIF_MOUSE Q99KR7 uc007srr.1 uc007srr.2 uc007srr.3 PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (By similarity). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:15800626, PubMed:15800627, PubMed:16103352, PubMed:18684715, PubMed:31489369). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:15800626, PubMed:15800627, PubMed:16103352, PubMed:18684715, PubMed:31489369). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (PubMed:19801635, PubMed:21281446). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (By similarity). Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Binds cyclosporin A (CsA). Is displaced by CsA from the mPTP leading to a lower open probability of the mPTP. Associates with the mitochondrial membrane ATP synthase F(1)F(0) ATP synthase; the association is increased by inorganic phosphate (Pi) and decreased by cyclosporin A (CsA) (PubMed:19801635). Interacts with ATP5F1B; ATP5PD and ATP5PO (PubMed:21281446). Interacts with SLC25A3; the interaction is impaired by CsA (By similarity). Interacts with BCL2; the interaction is impaired by CsA. Interacts with TP53; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by CsA (PubMed:22726440). Interacts with C1QBP (PubMed:20950273). Interacts with MCUR1 (By similarity). Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF (By similarity). Interacts with SPG7 (By similarity). Q99KR7; P02340: Tp53; NbExp=2; IntAct=EBI-6455001, EBI-474016; Q99KR7; P01023: A2M; Xeno; NbExp=3; IntAct=EBI-6455001, EBI-640741; Q99KR7; P50570-2: DNM2; Xeno; NbExp=3; IntAct=EBI-6455001, EBI-10968534; Q99KR7; P42858: HTT; Xeno; NbExp=3; IntAct=EBI-6455001, EBI-466029; Mitochondrion matrix Acetylated at Lys-166; deacetylated at Lys-166 by SIRT3. Mice are developmentally normal and show no apparent anomalies (PubMed:15800626, PubMed:15800627, PubMed:16103352). Mitochondria do not undergo cyclosporin A-sensitive mitochondrial permeability transtition (PubMed:15800626, PubMed:15800627, PubMed:16103352). Cells show resistance to necrotic cell death induced by reactive oxygen species and Ca(2+) overload, and animals show a high level of resistance to ischaemia/reperfusion-induced cardiac injury (PubMed:15800626, PubMed:15800627, PubMed:16103352). Mice show a dramatic reduction in brain infarct size after acute middle cerebral artery occlusion and reperfusion (PubMed:15800626, PubMed:15800627, PubMed:16103352). Mice lacking Slc25a4/Ant1, Slc25a5/Ant2, Slc25a31/Ant4 and Ppif lack Ca(2+)-induced mitochondrial permeability transition pore (mPTP) formation (PubMed:31489369). Belongs to the cyclophilin-type PPIase family. protein peptidyl-prolyl isomerization response to ischemia peptidyl-prolyl cis-trans isomerase activity protein binding mitochondrion mitochondrial inner membrane mitochondrial permeability transition pore complex mitochondrial matrix protein folding apoptotic process response to oxidative stress apoptotic mitochondrial changes regulation of proton-transporting ATPase activity, rotational mechanism regulation of necrotic cell death programmed cell death cyclosporin A binding isomerase activity negative regulation of ATPase activity protein refolding peptide binding regulation of apoptotic process negative regulation of apoptotic process regulation of mitochondrial membrane permeability unfolded protein binding necroptotic process cellular response to hydrogen peroxide cellular response to arsenic-containing substance cellular response to calcium ion positive regulation of release of cytochrome c from mitochondria negative regulation of release of cytochrome c from mitochondria negative regulation of oxidative phosphorylation regulation of mitochondrial membrane permeability involved in programmed necrotic cell death mitochondrial outer membrane permeabilization involved in programmed cell death negative regulation of oxidative phosphorylation uncoupler activity negative regulation of intrinsic apoptotic signaling pathway mitochondrial proton-transporting ATP synthase complex uc007srr.1 uc007srr.2 uc007srr.3 
ENSMUST00000022428.13 Rnase4 ENSMUST00000022428.13 ribonuclease, RNase A family 4, transcript variant 1 (from RefSeq NM_021472.4) ENSMUST00000022428.1 ENSMUST00000022428.10 ENSMUST00000022428.11 ENSMUST00000022428.12 ENSMUST00000022428.2 ENSMUST00000022428.3 ENSMUST00000022428.4 ENSMUST00000022428.5 ENSMUST00000022428.6 ENSMUST00000022428.7 ENSMUST00000022428.8 ENSMUST00000022428.9 NM_021472 Q8C7E4 Q8C7E4_MOUSE Rab1 Rnase4 uc007tmm.1 uc007tmm.2 uc007tmm.3 uc007tmm.4 This gene encodes a member of the pancreatic ribonuclease A superfamily. The encoded enzyme is sereted and has unique uridine specificity. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the angiogenin, ribonuclease, RNase A family, 5 gene. Each gene splices to a unique downstream exon that contains its complete coding region. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. [provided by RefSeq, Jun 2009]. Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity extracellular region hydrolase activity nucleic acid phosphodiester bond hydrolysis uc007tmm.1 uc007tmm.2 uc007tmm.3 uc007tmm.4 
ENSMUST00000022429.9 Arf4 ENSMUST00000022429.9 ADP-ribosylation factor 4 (from RefSeq NM_007479.4) Arf4 ENSMUST00000022429.1 ENSMUST00000022429.2 ENSMUST00000022429.3 ENSMUST00000022429.4 ENSMUST00000022429.5 ENSMUST00000022429.6 ENSMUST00000022429.7 ENSMUST00000022429.8 NM_007479 Q14BR4 Q14BR4_MOUSE uc007sta.1 uc007sta.2 uc007sta.3 GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus. Forms a complex containing RAB11A, ASAP1, RAB3IP, RAP11FIP3 and ARF4; the complex promotes preciliary trafficking; the complex binds to RHO in photoreceptor cells and promotes RHO ciliary transport. Golgi apparatus Belongs to the small GTPase superfamily. Arf family. nucleotide binding epidermal growth factor receptor binding GTP binding cytosol protein ADP-ribosylation retrograde vesicle-mediated transport, Golgi to ER epidermal growth factor receptor signaling pathway brain development cell migration activation of phospholipase D activity ruffle membrane negative regulation of apoptotic process dendritic spine positive regulation of transcription from RNA polymerase II promoter response to axon injury dendritic spine development regulation of reactive oxygen species metabolic process uc007sta.1 uc007sta.2 uc007sta.3 
ENSMUST00000022433.12 Dnah12 ENSMUST00000022433.12 dynein, axonemal, heavy chain 12 (from RefSeq NM_001370884.1) Dnah12 Dnahc12 E9QPU2 E9QPU2_MOUSE ENSMUST00000022433.1 ENSMUST00000022433.10 ENSMUST00000022433.11 ENSMUST00000022433.2 ENSMUST00000022433.3 ENSMUST00000022433.4 ENSMUST00000022433.5 ENSMUST00000022433.6 ENSMUST00000022433.7 ENSMUST00000022433.8 ENSMUST00000022433.9 NM_001370884 uc007stc.1 uc007stc.2 uc007stc.3 Belongs to the dynein heavy chain family. microtubule motor activity ATP binding microtubule-based movement uc007stc.1 uc007stc.2 uc007stc.3 
ENSMUST00000022437.16 Hacl1 ENSMUST00000022437.16 2-hydroxyacyl-CoA lyase 1 (from RefSeq NM_019975.3) ENSMUST00000022437.1 ENSMUST00000022437.10 ENSMUST00000022437.11 ENSMUST00000022437.12 ENSMUST00000022437.13 ENSMUST00000022437.14 ENSMUST00000022437.15 ENSMUST00000022437.2 ENSMUST00000022437.3 ENSMUST00000022437.4 ENSMUST00000022437.5 ENSMUST00000022437.6 ENSMUST00000022437.7 ENSMUST00000022437.8 ENSMUST00000022437.9 HACL1_MOUSE Hpcl NM_019975 Phyh2 Q543K1 Q9DAV1 Q9QXE0 uc007sxx.1 uc007sxx.2 uc007sxx.3 uc007sxx.4 Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (By similarity). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (By similarity). Plays a significant role in the biosynthesis of heptadecanal in the liver (PubMed:29027957). Reaction=a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA; Xref=Rhea:RHEA:25375, ChEBI:CHEBI:49188, ChEBI:CHEBI:57376, ChEBI:CHEBI:58783; EC=4.1.2.63; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25376; Evidence=; Reaction=an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA; Xref=Rhea:RHEA:67444, ChEBI:CHEBI:17176, ChEBI:CHEBI:57376, ChEBI:CHEBI:170012; EC=4.1.2.63; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67445; Evidence=; Reaction=2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA; Xref=Rhea:RHEA:25379, ChEBI:CHEBI:49190, ChEBI:CHEBI:57376, ChEBI:CHEBI:58784; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25380; Evidence=; Reaction=2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal; Xref=Rhea:RHEA:55196, ChEBI:CHEBI:57376, ChEBI:CHEBI:74116, ChEBI:CHEBI:138631; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55197; Evidence=; Reaction=2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA; Xref=Rhea:RHEA:25355, ChEBI:CHEBI:49189, ChEBI:CHEBI:57334, ChEBI:CHEBI:57376; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25356; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Note=Binds 1 thiamine pyrophosphate per subunit. ; Lipid metabolism; fatty acid metabolism. Homotetramer. Peroxisome Predominanly expressed in liver. Mice are viable and fertile and show no abnormal phenotype (PubMed:28629946, PubMed:29027957). However, upon dietary administration of phytol, phytanic acid accumulated in tissues, mainly in liver and serum of deficient mice. As a consequence of phytanic acid (or a metabolite) toxicity, deficent mice display a significant weight loss, absence of abdominal white adipose tissue, enlarged and mottled liver and reduced hepatic glycogen and triglyceride (PubMed:28629946). The presence of an other lyase, probably HCL2, can partially compensate for the lost of HCL1 (PubMed:28629946). Belongs to the TPP enzyme family. magnesium ion binding fatty acid alpha-oxidation catalytic activity peroxisome lipid metabolic process fatty acid metabolic process lyase activity carbon-carbon lyase activity thiamine pyrophosphate binding identical protein binding metal ion binding cofactor binding protein oligomerization uc007sxx.1 uc007sxx.2 uc007sxx.3 uc007sxx.4 
ENSMUST00000022446.7 Eaf1 ENSMUST00000022446.7 ELL associated factor 1 (from RefSeq NM_028932.4) EAF1_MOUSE ENSMUST00000022446.1 ENSMUST00000022446.2 ENSMUST00000022446.3 ENSMUST00000022446.4 ENSMUST00000022446.5 ENSMUST00000022446.6 NM_028932 Q9D4C5 uc007sxt.1 uc007sxt.2 uc007sxt.3 uc007sxt.4 Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with ELL and ELL2 (By similarity). Nucleus speckle Nucleus, Cajal body Belongs to the EAF family. nucleus nucleoplasm regulation of transcription, DNA-templated transcription elongation factor complex transcription factor binding Cajal body nuclear body nuclear speck ELL-EAF complex intracellular membrane-bounded organelle intercellular bridge positive regulation of transcription from RNA polymerase II promoter uc007sxt.1 uc007sxt.2 uc007sxt.3 uc007sxt.4 
ENSMUST00000022450.6 Tasor ENSMUST00000022450.6 transcription activation suppressor, transcript variant 2 (from RefSeq NM_028945.3) D14Abb1e E9PUH2 ENSMUST00000022450.1 ENSMUST00000022450.2 ENSMUST00000022450.3 ENSMUST00000022450.4 ENSMUST00000022450.5 Fam208a Kiaa1105 NM_028945 Q69ZR9 Q9CUD3 TASOR_MOUSE Tasor uc007stu.1 uc007stu.2 uc007stu.3 uc007stu.4 uc007stu.5 Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (By similarity). Plays a crucial role in early embryonic development (PubMed:31112734, PubMed:24781204, PubMed:28839193). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (PubMed:31112734). Plays an important role in maintaining epiblast fitness or potency (PubMed:28839193). Component of the HUSH complex; at least composed of TASOR, PPHLN1 and MPHOSPH8 (By similarity). Interacts with MORC2; the interaction associateS MORC2 with the HUSH complex which recruits MORC2 to heterochromatic loci (By similarity). Interacts with ZNF638; leading to recruitment of the HUSH complex to unintegrated retroviral DNA (By similarity). Interacts with INPP5A, EML1, SV1L, GPSM2, ITGB3BP, CNTN1, ETFA, PSMD8, S100A10, MPHOSPH8, TMEM100, ALB, PARPBP, HCFC2, NCBP1 and SETDB1 (PubMed:31112734). Nucleus Chromosome Note=Localizes to chromatin. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69ZR9-1; Sequence=Displayed; Name=2; IsoId=Q69ZR9-2; Sequence=VSP_042114, VSP_042115, VSP_042116, VSP_042117; Present in skin, brain and testis (at protein level) (PubMed:24781204). Ubiquitously expressed at low levels in the majority of the organs, expressed at higher levels in kidneys, spleen, thymus, seminal vesicles, uterus, and ovaries and its expression is almost six times higher in male tissues than in females (PubMed:31112734). Highly expressed in seminiferous tubules with a strong signal in Sertoli cells, spermatogonia, and spermatocytes (PubMed:31112734). Expressed in the epiblast at 5.5 dpc, expression extends into the extraembryonic ectoderm at 6.5 dpc, and at 7.5 dpc expressed in embryonic ectoderm, allantois, amnion and chorion. From 8.5 to 9.5 dpc, ubiquitously expressed in the developing embryo. Embryonic lethality with robust developmentally delayed phenotype observed at 8.5 dpc, progressing through 9.5 dpc with full lethality by 12.5 dpc (PubMed:24781204, PubMed:28839193). RNAi- mediated knockdown in zygotes results in formation of multipolar spindles and increased ratio of arrested or incorrectly developed embryos (PubMed:28839193). Belongs to the TASOR family. heterochromatin chromatin binding nucleus nucleoplasm chromosome negative regulation of gene expression, epigenetic negative regulation of single stranded viral RNA replication via double stranded DNA intermediate positive regulation of methylation-dependent chromatin silencing protein localization to heterochromatin uc007stu.1 uc007stu.2 uc007stu.3 uc007stu.4 uc007stu.5 
ENSMUST00000022451.14 Capn7 ENSMUST00000022451.14 calpain 7, transcript variant 1 (from RefSeq NM_009796.4) CAN7_MOUSE ENSMUST00000022451.1 ENSMUST00000022451.10 ENSMUST00000022451.11 ENSMUST00000022451.12 ENSMUST00000022451.13 ENSMUST00000022451.2 ENSMUST00000022451.3 ENSMUST00000022451.4 ENSMUST00000022451.5 ENSMUST00000022451.6 ENSMUST00000022451.7 ENSMUST00000022451.8 ENSMUST00000022451.9 NM_009796 Palbh Q9R1S8 Q9Z0P9 uc007sxm.1 uc007sxm.2 uc007sxm.3 uc007sxm.4 Calcium-regulated non-lysosomal thiol-protease. Nucleus Ubiquitous. Belongs to the peptidase C2 family. Sequence=CAB39203.1; Type=Erroneous initiation; Evidence=; endopeptidase activity calcium-dependent cysteine-type endopeptidase activity nucleus proteolysis peptidase activity cysteine-type peptidase activity positive regulation of epithelial cell migration hydrolase activity MIT domain binding self proteolysis uc007sxm.1 uc007sxm.2 uc007sxm.3 uc007sxm.4 
ENSMUST00000022458.11 Bap1 ENSMUST00000022458.11 Brca1 associated protein 1 (from RefSeq NM_027088.2) BAP1_MOUSE ENSMUST00000022458.1 ENSMUST00000022458.10 ENSMUST00000022458.2 ENSMUST00000022458.3 ENSMUST00000022458.4 ENSMUST00000022458.5 ENSMUST00000022458.6 ENSMUST00000022458.7 ENSMUST00000022458.8 ENSMUST00000022458.9 Kiaa0272 NM_027088 Q3TCR6 Q6ZQE6 Q99PU7 uc007sxh.1 uc007sxh.2 uc007sxh.3 Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM- like motif) with HCFC1. Interacts (when phosphorylated at Thr-492) with FOXK1. Interacts (when phosphorylated at Thr-492) with FOXK2; leading to recruit the PR-DUB complex and repress FOXK2 target genes. Cytoplasm Nucleus Note=Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O. Highly expressed in mammary glands, testis and ovary. Up-regulated in mammary glands during puberty, pregnancy, and as a result of parity. Ubiquitinated: monoubiquitinated at multiple site of its nuclear localization signal (NLS) BY UBE2O, leading to cytoplasmic retention. Able to mediate autodeubiquitination via intramolecular interactions to couteract cytoplasmic retention. Has the ability to ability to suppress tumorigenicity when expressed in NCI-H226 cells. Belongs to the peptidase C12 family. BAP1 subfamily. Sequence=BAC97918.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; regulation of cell growth chromatin binding thiol-dependent ubiquitin-specific protease activity protein binding nucleus nucleoplasm cytoplasm cytosol chromatin organization proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity negative regulation of cell proliferation response to inorganic substance protein deubiquitination hydrolase activity PR-DUB complex monoubiquitinated protein deubiquitination monoubiquitinated histone H2A deubiquitination thiol-dependent ubiquitinyl hydrolase activity negative regulation of transcription, DNA-templated regulation of inflammatory response regulation of cell cycle macrophage homeostasis protein K48-linked deubiquitination regulation of cytokine production involved in inflammatory response uc007sxh.1 uc007sxh.2 uc007sxh.3 
ENSMUST00000022459.5 Phf7 ENSMUST00000022459.5 PHD finger protein 7, transcript variant 5 (from RefSeq NR_153761.1) ENSMUST00000022459.1 ENSMUST00000022459.2 ENSMUST00000022459.3 ENSMUST00000022459.4 NR_153761 PHF7_MOUSE Q6PG81 Q9DAG9 uc007sxf.1 uc007sxf.2 uc007sxf.3 May play a role in spermatogenesis. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DAG9-1; Sequence=Displayed; Name=2; IsoId=Q9DAG9-2; Sequence=VSP_013491; Highly expressed in Sertoli cells in testis. Expression levels increase during the first 4 weeks after birth and remain constant during the following 3 weeks. nucleus nucleoplasm Golgi apparatus cytosol plasma membrane biological_process nuclear speck metal ion binding uc007sxf.1 uc007sxf.2 uc007sxf.3 
ENSMUST00000022460.11 Galnt15 ENSMUST00000022460.11 polypeptide N-acetylgalactosaminyltransferase 15 (from RefSeq NM_030166.3) A3KN88 ENSMUST00000022460.1 ENSMUST00000022460.10 ENSMUST00000022460.2 ENSMUST00000022460.3 ENSMUST00000022460.4 ENSMUST00000022460.5 ENSMUST00000022460.6 ENSMUST00000022460.7 ENSMUST00000022460.8 ENSMUST00000022460.9 GLT15_MOUSE Galntl2 NM_030166 Q9D2N8 uc007syb.1 uc007syb.2 uc007syb.3 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate (By similarity). Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Specifically expressed in testis. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Name=Functional Glycomics Gateway - GTase; Note=Polypeptide N-acetylgalactosaminyltransferase-like protein 2; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_527"; Golgi membrane molecular_function polypeptide N-acetylgalactosaminyltransferase activity Golgi apparatus protein glycosylation biological_process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transport vesicle carbohydrate binding metal ion binding uc007syb.1 uc007syb.2 uc007syb.3 
ENSMUST00000022461.11 Dph3 ENSMUST00000022461.11 diphthamine biosynthesis 3, transcript variant 3 (from RefSeq NM_001284346.1) DPH3_MOUSE Desr1 Dph3 ENSMUST00000022461.1 ENSMUST00000022461.10 ENSMUST00000022461.2 ENSMUST00000022461.3 ENSMUST00000022461.4 ENSMUST00000022461.5 ENSMUST00000022461.6 ENSMUST00000022461.7 ENSMUST00000022461.8 ENSMUST00000022461.9 NM_001284346 Q8K0W9 Zcsl2 uc007sye.1 uc007sye.2 uc007sye.3 uc007sye.4 Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5- methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). Reaction=[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]; Xref=Rhea:RHEA:71235, Rhea:RHEA-COMP:17996, Rhea:RHEA-COMP:17997, Rhea:RHEA-COMP:18002, Rhea:RHEA-COMP:18003, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:33751, ChEBI:CHEBI:47402, ChEBI:CHEBI:83228; Evidence=; Reaction=2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe- 4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+); Xref=Rhea:RHEA:71239, Rhea:RHEA-COMP:17997, Rhea:RHEA-COMP:17998, Rhea:RHEA-COMP:18001, Rhea:RHEA-COMP:18002, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:33723, ChEBI:CHEBI:47402, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83228; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Protein modification; peptidyl-diphthamide biosynthesis. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase (By similarity). Interacts with SERGEF (By similarity). Cytoplasm Nucleus Widely expressed with highest levels in heart, liver, kidney and testis. In the embryo, expressed during all stages of development. The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function. Embryonic lethal about 11.5 days after fertilization (PubMed:16648478). Decreases metastasis in a mouse model of melanoma (PubMed:23185508). Belongs to the DPH3 family. tRNA wobble uridine modification nucleus nucleoplasm cytoplasm cytosol peptidyl-diphthamide biosynthetic process from peptidyl-histidine metal ion binding negative regulation of protein secretion positive regulation of binding uc007sye.1 uc007sye.2 uc007sye.3 uc007sye.4 
ENSMUST00000022462.14 Oxnad1 ENSMUST00000022462.14 oxidoreductase NAD-binding domain containing 1 (from RefSeq NM_145460.2) ENSMUST00000022462.1 ENSMUST00000022462.10 ENSMUST00000022462.11 ENSMUST00000022462.12 ENSMUST00000022462.13 ENSMUST00000022462.2 ENSMUST00000022462.3 ENSMUST00000022462.4 ENSMUST00000022462.5 ENSMUST00000022462.6 ENSMUST00000022462.7 ENSMUST00000022462.8 ENSMUST00000022462.9 NM_145460 OXND1_MOUSE Q3UT09 Q8C093 Q8VE38 uc007syg.1 uc007syg.2 uc007syg.3 uc007syg.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VE38-1; Sequence=Displayed; Name=2; IsoId=Q8VE38-2; Sequence=VSP_027765; mitochondrion oxidoreductase activity oxidation-reduction process uc007syg.1 uc007syg.2 uc007syg.3 uc007syg.4 
ENSMUST00000022464.14 Msmb ENSMUST00000022464.14 beta-microseminoprotein (from RefSeq NM_020597.3) ENSMUST00000022464.1 ENSMUST00000022464.10 ENSMUST00000022464.11 ENSMUST00000022464.12 ENSMUST00000022464.13 ENSMUST00000022464.2 ENSMUST00000022464.3 ENSMUST00000022464.4 ENSMUST00000022464.5 ENSMUST00000022464.6 ENSMUST00000022464.7 ENSMUST00000022464.8 ENSMUST00000022464.9 MSMB_MOUSE NM_020597 O08540 Psp94 uc007syi.1 uc007syi.2 uc007syi.3 uc007syi.4 uc007syi.5 Homodimer; Interacts with PI16. Secreted. Note=Sperm surface. Belongs to the beta-microseminoprotein family. molecular_function cellular_component extracellular region biological_process uc007syi.1 uc007syi.2 uc007syi.3 uc007syi.4 uc007syi.5 
ENSMUST00000022470.15 Parg ENSMUST00000022470.15 poly (ADP-ribose) glycohydrolase, transcript variant 1 (from RefSeq NM_011960.3) ENSMUST00000022470.1 ENSMUST00000022470.10 ENSMUST00000022470.11 ENSMUST00000022470.12 ENSMUST00000022470.13 ENSMUST00000022470.14 ENSMUST00000022470.2 ENSMUST00000022470.3 ENSMUST00000022470.4 ENSMUST00000022470.5 ENSMUST00000022470.6 ENSMUST00000022470.7 ENSMUST00000022470.8 ENSMUST00000022470.9 G3X8U8 G3X8U8_MOUSE NM_011960 Parg uc007syr.1 uc007syr.2 uc007syr.3 uc007syr.4 Belongs to the poly(ADP-ribose) glycohydrolase family. poly(ADP-ribose) glycohydrolase activity nucleus nucleoplasm cytosol carbohydrate metabolic process hydrolase activity intracellular membrane-bounded organelle ATP generation from poly-ADP-D-ribose uc007syr.1 uc007syr.2 uc007syr.3 uc007syr.4 
ENSMUST00000022494.10 Ebpl ENSMUST00000022494.10 emopamil binding protein-like (from RefSeq NM_026598.3) EBPL_MOUSE ENSMUST00000022494.1 ENSMUST00000022494.2 ENSMUST00000022494.3 ENSMUST00000022494.4 ENSMUST00000022494.5 ENSMUST00000022494.6 ENSMUST00000022494.7 ENSMUST00000022494.8 ENSMUST00000022494.9 Ebrp Erp NM_026598 Q3TQR1 Q9CRQ2 Q9CY81 Q9D0P0 uc007ufv.1 uc007ufv.2 uc007ufv.3 uc007ufv.4 Does not possess sterol isomerase activity and does not bind sigma ligands. Homodimer. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the EBP family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane biological_process membrane integral component of membrane sterol metabolic process cholestenol delta-isomerase activity uc007ufv.1 uc007ufv.2 uc007ufv.3 uc007ufv.4 
ENSMUST00000022496.9 Kpna3 ENSMUST00000022496.9 karyopherin subunit alpha 3 (from RefSeq NM_008466.5) ENSMUST00000022496.1 ENSMUST00000022496.2 ENSMUST00000022496.3 ENSMUST00000022496.4 ENSMUST00000022496.5 ENSMUST00000022496.6 ENSMUST00000022496.7 ENSMUST00000022496.8 Kpna3 NM_008466 Q543M7 Q543M7_MOUSE uc007ufw.1 uc007ufw.2 uc007ufw.3 uc007ufw.4 Functions in nuclear protein import. Belongs to the importin alpha family. nucleus cytoplasm protein import into nucleus protein transport nuclear import signal receptor activity uc007ufw.1 uc007ufw.2 uc007ufw.3 uc007ufw.4 
ENSMUST00000022497.15 Spryd7 ENSMUST00000022497.15 SPRY domain containing 7, transcript variant 1 (from RefSeq NM_025697.4) Clld6 ENSMUST00000022497.1 ENSMUST00000022497.10 ENSMUST00000022497.11 ENSMUST00000022497.12 ENSMUST00000022497.13 ENSMUST00000022497.14 ENSMUST00000022497.2 ENSMUST00000022497.3 ENSMUST00000022497.4 ENSMUST00000022497.5 ENSMUST00000022497.6 ENSMUST00000022497.7 ENSMUST00000022497.8 ENSMUST00000022497.9 NM_025697 Q3TFQ1 Q8K1Y1 Q9CU44 Q9D368 Q9D3D1 SPRY7_MOUSE uc007ufx.1 uc007ufx.2 uc007ufx.3 uc007ufx.4 molecular_function cellular_component biological_process uc007ufx.1 uc007ufx.2 uc007ufx.3 uc007ufx.4 
ENSMUST00000022499.13 Rnaseh2b ENSMUST00000022499.13 ribonuclease H2, subunit B (from RefSeq NM_026001.3) Dleu8 ENSMUST00000022499.1 ENSMUST00000022499.10 ENSMUST00000022499.11 ENSMUST00000022499.12 ENSMUST00000022499.2 ENSMUST00000022499.3 ENSMUST00000022499.4 ENSMUST00000022499.5 ENSMUST00000022499.6 ENSMUST00000022499.7 ENSMUST00000022499.8 ENSMUST00000022499.9 NM_026001 Q80ZV0 Q9D014 RNH2B_MOUSE uc007ugl.1 uc007ugl.2 uc007ugl.3 Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C. Nucleus Belongs to the RNase H2 subunit B family. in utero embryonic development RNA-DNA hybrid ribonuclease activity nucleus nucleoplasm RNA catabolic process ribonucleotide metabolic process regulation of G2/M transition of mitotic cell cycle negative regulation of gene expression ribonuclease H2 complex positive regulation of fibroblast proliferation RNA phosphodiester bond hydrolysis, endonucleolytic regulation of DNA damage checkpoint uc007ugl.1 uc007ugl.2 uc007ugl.3 
ENSMUST00000022504.12 Mapk8 ENSMUST00000022504.12 mitogen-activated protein kinase 8, transcript variant 5 (from RefSeq NR_188805.1) ENSMUST00000022504.1 ENSMUST00000022504.10 ENSMUST00000022504.11 ENSMUST00000022504.2 ENSMUST00000022504.3 ENSMUST00000022504.4 ENSMUST00000022504.5 ENSMUST00000022504.6 ENSMUST00000022504.7 ENSMUST00000022504.8 ENSMUST00000022504.9 G3X8U9 G3X8U9_MOUSE Mapk8 NR_188805 uc007szr.1 uc007szr.2 uc007szr.3 uc007szr.4 uc007szr.5 uc007szr.6 Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Cytoplasm Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity JUN kinase activity MAP kinase activity ATP binding nucleus protein phosphorylation JNK cascade JUN phosphorylation response to UV positive regulation of gene expression kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation enzyme binding regulation of histone deacetylation positive regulation of cyclase activity negative regulation of protein binding regulation of protein localization cellular response to amino acid starvation cellular response to reactive oxygen species histone deacetylase regulator activity histone deacetylase binding negative regulation of apoptotic process positive regulation of protein metabolic process stress-activated MAPK cascade cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to cadmium ion positive regulation of deacetylase activity regulation of DNA replication origin binding uc007szr.1 uc007szr.2 uc007szr.3 uc007szr.4 uc007szr.5 uc007szr.6 
ENSMUST00000022507.13 Pspc1 ENSMUST00000022507.13 paraspeckle protein 1, transcript variant 1 (from RefSeq NM_025682.4) ENSMUST00000022507.1 ENSMUST00000022507.10 ENSMUST00000022507.11 ENSMUST00000022507.12 ENSMUST00000022507.2 ENSMUST00000022507.3 ENSMUST00000022507.4 ENSMUST00000022507.5 ENSMUST00000022507.6 ENSMUST00000022507.7 ENSMUST00000022507.8 ENSMUST00000022507.9 NM_025682 PSPC1_MOUSE Psp1 Q3TUK2 Q8R326 Q9CYH1 Q9D0M8 uc007ucj.1 uc007ucj.2 uc007ucj.3 Together with NONO, required for the formation of nuclear paraspeckles. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Forms heterodimers with NONO; this involves formation of a coiled coil domain by helices from both proteins (By similarity). Interaction with NONO is required for its targeting to paraspeckles and perinucleolar caps (By similarity). Found in a RNP complex with CAT2 transcribed nuclear RNA (CTN-RNA). Interacts with NONO and SFPQ. Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA. Q8R326; O88609: Lmx1b; NbExp=3; IntAct=EBI-309927, EBI-13951208; Q8R326; Q8VIJ6: Sfpq; NbExp=2; IntAct=EBI-309927, EBI-6094576; Nucleus, nucleolus Note=In punctate subnuclear structures localized adjacent to nuclear splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycle between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps. [Isoform 1]: Nucleus matrix. Cytoplasm. Nucleus speckle Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PSP1-alpha; IsoId=Q8R326-1; Sequence=Displayed; Name=2; Synonyms=PSP1-beta; IsoId=Q8R326-2; Sequence=VSP_027276, VSP_027277; Isoform 1 is strongly expressed in testis (leptoten spermatocytes, round spematids and Sertoli cells) and moderately in cerebrum, cerebellum, lung, spleen and ovary (at protein level). Isoform 2 is strongly expressed in kidney and moderately in salivary gland (at protein level). Belongs to the PSPC family. transcription regulatory region sequence-specific DNA binding fibrillar center activation of innate immune response immune system process nucleic acid binding RNA binding protein binding nucleus nucleoplasm nucleolus cytoplasm nuclear matrix nuclear speck paraspeckles regulation of circadian rhythm innate immune response negative regulation of transcription, DNA-templated rhythmic process E-box binding uc007ucj.1 uc007ucj.2 uc007ucj.3 
ENSMUST00000022508.8 Ptpn20 ENSMUST00000022508.8 protein tyrosine phosphatase, non-receptor type 20 (from RefSeq NM_008978.2) A4QPF6 ENSMUST00000022508.1 ENSMUST00000022508.2 ENSMUST00000022508.3 ENSMUST00000022508.4 ENSMUST00000022508.5 ENSMUST00000022508.6 ENSMUST00000022508.7 NM_008978 O55082 PTN20_MOUSE Typ uc007szx.1 uc007szx.2 uc007szx.3 Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Nucleus Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with the microtubule-organizing center and intracellular membrane compartments. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O55082-1; Sequence=Displayed; Name=2; IsoId=O55082-2; Sequence=VSP_027074, VSP_027075; Testis-specific. Specifically expressed in testicular germ cells that undergo meiosis (at protein level). Detected between 2 and 3 weeks after birth, in parallel with the onset of meiosis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm microtubule organizing center cytoskeleton microtubule protein dephosphorylation dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc007szx.1 uc007szx.2 uc007szx.3 
ENSMUST00000022511.10 Zmym2 ENSMUST00000022511.10 zinc finger, MYM-type 2, transcript variant 2 (from RefSeq NM_029498.4) B2RUS2 ENSMUST00000022511.1 ENSMUST00000022511.2 ENSMUST00000022511.3 ENSMUST00000022511.4 ENSMUST00000022511.5 ENSMUST00000022511.6 ENSMUST00000022511.7 ENSMUST00000022511.8 ENSMUST00000022511.9 NM_029498 Q3UUZ8 Q3UXK7 Q80XP0 Q9CU65 ZMYM2_MOUSE Zfp198 Znf198 uc007uct.1 uc007uct.2 uc007uct.3 uc007uct.4 This gene encodes a protein that contains nine MYM-type zinc finger motifs. Expression of this gene may mediate the inhibition of hematopoietic cell development during ontogeny, and the encoded protein may also play a role in transforming growth factor-beta signaling as a Smad binding protein. [provided by RefSeq, Feb 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.258645.1, SRR1660817.150611.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Involved in the negative regulation of transcription. Can form homodimers (By similarity). May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with FOXP1 and FOXP2 (By similarity). Nucleus Low but widespread expression is detected in the developing kidney. RNA polymerase II transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription from RNA polymerase II promoter zinc ion binding PML body regulation of cell morphogenesis ubiquitin conjugating enzyme binding metal ion binding uc007uct.1 uc007uct.2 uc007uct.3 uc007uct.4 
ENSMUST00000022517.9 Cryl1 ENSMUST00000022517.9 crystallin, lambda 1 (from RefSeq NM_030004.3) CRYL1_MOUSE Cry ENSMUST00000022517.1 ENSMUST00000022517.2 ENSMUST00000022517.3 ENSMUST00000022517.4 ENSMUST00000022517.5 ENSMUST00000022517.6 ENSMUST00000022517.7 ENSMUST00000022517.8 NM_030004 Q542R9 Q8R4W7 Q99KP3 uc007ucz.1 uc007ucz.2 uc007ucz.3 Has high L-gulonate 3-dehydrogenase activity. It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate. Reaction=L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH; Xref=Rhea:RHEA:12889, ChEBI:CHEBI:13115, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57655, ChEBI:CHEBI:57945; EC=1.1.1.45; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12890; Evidence=; Inhibited by malonate. Homodimer. Cytoplasm Widely expressed, with highest levels in liver. Undetectable in skeletal muscle. Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. Sequence=AAM13398.1; Type=Frameshift; Evidence=; 3-hydroxyacyl-CoA dehydrogenase activity cytoplasm cytosol fatty acid metabolic process oxidoreductase activity protein homodimerization activity L-gulonate 3-dehydrogenase activity oxidation-reduction process NAD+ binding uc007ucz.1 uc007ucz.2 uc007ucz.3 
ENSMUST00000022519.15 Anxa8 ENSMUST00000022519.15 annexin A8, transcript variant 1 (from RefSeq NM_013473.4) ANXA8_MOUSE Anx8 ENSMUST00000022519.1 ENSMUST00000022519.10 ENSMUST00000022519.11 ENSMUST00000022519.12 ENSMUST00000022519.13 ENSMUST00000022519.14 ENSMUST00000022519.2 ENSMUST00000022519.3 ENSMUST00000022519.4 ENSMUST00000022519.5 ENSMUST00000022519.6 ENSMUST00000022519.7 ENSMUST00000022519.8 ENSMUST00000022519.9 NM_013473 O35640 Q8K2N9 uc007taj.1 uc007taj.2 uc007taj.3 uc007taj.4 uc007taj.5 This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. A pair of annexin repeats may form one binding site for calcium and phospholipid. Belongs to the annexin family. calcium ion binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding cytosol plasma membrane endosome organization blood coagulation hemostasis endosomal transport late endosome membrane phosphatidylinositol-3,4-bisphosphate binding metal ion binding actin filament binding negative regulation of serine-type endopeptidase activity negative regulation of phospholipase A2 activity uc007taj.1 uc007taj.2 uc007taj.3 uc007taj.4 uc007taj.5 
ENSMUST00000022522.15 Tdh ENSMUST00000022522.15 L-threonine dehydrogenase (from RefSeq NM_021480.5) ENSMUST00000022522.1 ENSMUST00000022522.10 ENSMUST00000022522.11 ENSMUST00000022522.12 ENSMUST00000022522.13 ENSMUST00000022522.14 ENSMUST00000022522.2 ENSMUST00000022522.3 ENSMUST00000022522.4 ENSMUST00000022522.5 ENSMUST00000022522.6 ENSMUST00000022522.7 ENSMUST00000022522.8 ENSMUST00000022522.9 NM_021480 Q6PD91 Q8K3F7 Q9JLU3 TDH_MOUSE Tdh uc007uhs.1 uc007uhs.2 Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate, mediating L-threonine catabolism. Reaction=L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH; Xref=Rhea:RHEA:13161, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57926, ChEBI:CHEBI:57945, ChEBI:CHEBI:78948; EC=1.1.1.103; Evidence=; Kinetic parameters: KM=72.4 mM for L-threonine ; KM=1.67 mM for NAD(+) ; Amino-acid degradation; L-threonine degradation via oxydo- reductase pathway; glycine from L-threonine: step 1/2. Homodimer. Mitochondrion Belongs to the NAD(P)-dependent epimerase/dehydratase family. catalytic activity mitochondrion threonine catabolic process L-threonine 3-dehydrogenase activity oxidoreductase activity L-threonine catabolic process to glycine identical protein binding coenzyme binding oxidation-reduction process uc007uhs.1 uc007uhs.2 
ENSMUST00000022528.6 Pinx1 ENSMUST00000022528.6 PIN2/TERF1 interacting, telomerase inhibitor 1 (from RefSeq NM_028228.4) ENSMUST00000022528.1 ENSMUST00000022528.2 ENSMUST00000022528.3 ENSMUST00000022528.4 ENSMUST00000022528.5 Lpts NM_028228 PINX1_MOUSE Q14BS4 Q3V450 Q8C6E5 Q91WZ9 Q9CZX5 Q9D0C2 uc007uhx.1 uc007uhx.2 uc007uhx.3 uc007uhx.4 Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor (By similarity). Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA. Nucleus Nucleus, nucleolus Chromosome, telomere Chromosome, centromere, kinetochore Note=Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE (By similarity). The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibits its activity. The TBM domain mediates interaction with TERF1. Belongs to the PINX1 family. nuclear chromosome chromosome, centromeric region kinetochore condensed chromosome kinetochore chromosome, telomeric region nuclear chromosome, telomeric region nucleic acid binding nucleus chromosome nucleolus spindle telomere maintenance via telomerase mitotic metaphase plate congression telomerase inhibitor activity negative regulation of G2/M transition of mitotic cell cycle negative regulation of protein ubiquitination regulation of protein stability negative regulation of telomere maintenance via telomerase macromolecular complex binding negative regulation of telomerase activity telomerase RNA binding protein localization to chromosome, telomeric region protein localization to nucleolus positive regulation of telomeric DNA binding positive regulation of protein localization to nucleolus uc007uhx.1 uc007uhx.2 uc007uhx.3 uc007uhx.4 
ENSMUST00000022529.8 Tkt ENSMUST00000022529.8 transketolase (from RefSeq NM_009388.6) ENSMUST00000022529.1 ENSMUST00000022529.2 ENSMUST00000022529.3 ENSMUST00000022529.4 ENSMUST00000022529.5 ENSMUST00000022529.6 ENSMUST00000022529.7 NM_009388 P40142 Q3U7Y1 Q3UK62 Q545A1 Q9ESA0 TKT_MOUSE uc007svc.1 uc007svc.2 uc007svc.3 uc007svc.4 uc007svc.5 This gene encodes an enzyme that binds magnesium and thiamine pyrophosphate and catalyzes the transfer of sugar phosphates to an aldose acceptor. This enzyme is a key component of the pentose phosphate pathway during glycolysis. It is significantly expressed in the cornea and may be involved in the cellular response against oxidative stress. Haploinsufficiency of this gene leads to decreased growth and reduction of adipose tissue. [provided by RefSeq, Dec 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK030446.1, AK166763.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Reaction=D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate; Xref=Rhea:RHEA:10508, ChEBI:CHEBI:57483, ChEBI:CHEBI:57737, ChEBI:CHEBI:58273, ChEBI:CHEBI:59776; EC=2.2.1.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). ; Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Note=Binds 1 thiamine pyrophosphate per subunit. ; Homodimer. Belongs to the transketolase family. magnesium ion binding catalytic activity transketolase activity nucleoplasm peroxisome endoplasmic reticulum membrane pentose-phosphate shunt pentose-phosphate shunt, non-oxidative branch nuclear body nuclear speck transferase activity carbohydrate binding thiamine pyrophosphate binding regulation of growth protein homodimerization activity myelin sheath intracellular membrane-bounded organelle glyceraldehyde-3-phosphate biosynthetic process ribose phosphate biosynthetic process metal ion binding monosaccharide binding cofactor binding uc007svc.1 uc007svc.2 uc007svc.3 uc007svc.4 uc007svc.5 
ENSMUST00000022531.14 Lats2 ENSMUST00000022531.14 large tumor suppressor 2, transcript variant A (from RefSeq NM_015771.2) ENSMUST00000022531.1 ENSMUST00000022531.10 ENSMUST00000022531.11 ENSMUST00000022531.12 ENSMUST00000022531.13 ENSMUST00000022531.2 ENSMUST00000022531.3 ENSMUST00000022531.4 ENSMUST00000022531.5 ENSMUST00000022531.6 ENSMUST00000022531.7 ENSMUST00000022531.8 ENSMUST00000022531.9 LATS2_MOUSE Lats2 NM_015771 Q7TSJ6 Q8CDJ4 Q9JMI3 uc007udk.1 uc007udk.2 Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with and is phosphorylated by AURKA. Binds to AR (By similarity). Interacts with AJUBA during mitosis and this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome. Interacts (via PPxY motif) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B (By similarity). Interacts with LIMD1, WTIP and AJUBA (By similarity). Interacts with SNAI1 (By similarity). Interacts with WWC1, WWC2 and WWC3 (via their WW domains) (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm Cytoplasm, cytoskeleton, spindle pole Nucleus Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis (By similarity). Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment (By similarity). Expressed at high levels in ovary and testis and at lower levels in all other tissues examined. Autophosphorylated and phosphorylated during M-phase and the G1/S- phase of the cell cycle. Phosphorylated and activated by STK3/MST2. Phosphorylation by NUAK2 may regulate its activity in phosphorylation and inactivation YAP1. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Sequence=BAC26704.1; Type=Frameshift; Evidence=; G1/S transition of mitotic cell cycle nucleotide binding spindle pole inner cell mass cell fate commitment inner cell mass cellular morphogenesis protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm microtubule organizing center cytosol cytoskeleton protein phosphorylation cell cycle hormone-mediated signaling pathway kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation keratinocyte differentiation cellular protein localization hippo signaling intracellular signal transduction positive regulation of apoptotic process negative regulation of cyclin-dependent protein serine/threonine kinase activity regulation of organ growth metal ion binding cell division negative regulation of canonical Wnt signaling pathway uc007udk.1 uc007udk.2 
ENSMUST00000022532.6 4930578I06Rik ENSMUST00000022532.6 RIKEN cDNA 4930578I06 gene (from RefSeq NM_026359.4) CH074_MOUSE ENSMUST00000022532.1 ENSMUST00000022532.2 ENSMUST00000022532.3 ENSMUST00000022532.4 ENSMUST00000022532.5 NM_026359 Q80ZQ3 Q9CVZ7 uc288vdv.1 uc288vdv.2 Sequence=BAB24234.2; Type=Frameshift; Evidence=; Sequence=BAC25478.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc288vdv.1 uc288vdv.2 
ENSMUST00000022535.9 Dcp1a ENSMUST00000022535.9 decapping mRNA 1A, transcript variant 1 (from RefSeq NM_133761.4) DCP1A_MOUSE ENSMUST00000022535.1 ENSMUST00000022535.2 ENSMUST00000022535.3 ENSMUST00000022535.4 ENSMUST00000022535.5 ENSMUST00000022535.6 ENSMUST00000022535.7 ENSMUST00000022535.8 Mitc1 NM_133761 Q6NZE3 Q91YD3 Smif uc007sva.1 uc007sva.2 uc007sva.3 Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1 (By similarity). Essential for embryonic development (PubMed:11836524). Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP; Xref=Rhea:RHEA:67484, Rhea:RHEA-COMP:15692, Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:63714, ChEBI:CHEBI:138282, ChEBI:CHEBI:156461; EC=3.6.1.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67485; Evidence=; Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with DCP1B. Interacts with DCP2. Interacts with DDX17 in an RNA-independent manner. Interacts with PNRC2. Interacts with SMAD4. Interacts with UPF1. Interacts with ZC3HAV1. Interacts with ZFP36L1. Interacts with NBDY. Interacts with DHX34; the interaction is RNA-independent (By similarity). Cytoplasm, P-body cleus Note=Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (By similarity). Colocalizes with NANOS3 in the processing bodies (PubMed:19861488). Ubiquitous, with highest expression in the spleen and testis (at protein level). Expression detectable at 9.5 dpc and progressively increases from 11.5 dpc onwards (at protein level). Embryonic lethality around embryonic day 10.5 concomitant with massive growth retardation and cardiac developmental defects seen. Belongs to the DCP1 family. It is uncertain whether Met-1 or Met-21 is the initiator. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay deadenylation-dependent decapping of nuclear-transcribed mRNA P-body nucleus transcription factor complex cytoplasm transforming growth factor beta receptor signaling pathway enzyme activator activity transcription factor binding hydrolase activity kinesin binding deadenylation-independent decapping of nuclear-transcribed mRNA cytoplasmic ribonucleoprotein granule identical protein binding positive regulation of catalytic activity positive regulation of transcription, DNA-templated protein localization to cytoplasmic stress granule uc007sva.1 uc007sva.2 uc007sva.3 
ENSMUST00000022536.3 Ska3 ENSMUST00000022536.3 spindle and kinetochore associated complex subunit 3, transcript variant 5 (from RefSeq NR_184859.1) ENSMUST00000022536.1 ENSMUST00000022536.2 NR_184859 Q149T5 Q149T6 Q8C263 Rama1 SKA3_MOUSE uc007udp.1 uc007udp.2 Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts with SKA1; the interaction is direct. Cytoplasm, cytoskeleton, spindle Chromosome, centromere, kinetochore Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Belongs to the SKA3 family. mitotic cell cycle chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed chromosome outer kinetochore molecular_function chromosome cytoplasm spindle cytoskeleton microtubule spindle microtubule cell cycle chromosome segregation regulation of microtubule polymerization or depolymerization cell division uc007udp.1 uc007udp.2 
ENSMUST00000022537.6 Prss52 ENSMUST00000022537.6 serine protease 52 (from RefSeq NM_028525.2) A8C1Y0 ENSMUST00000022537.1 ENSMUST00000022537.2 ENSMUST00000022537.3 ENSMUST00000022537.4 ENSMUST00000022537.5 NM_028525 PRS52_MOUSE Q80Y38 Q9D9M0 Tesp3 uc007uie.1 uc007uie.2 uc007uie.3 Probable serine protease. Membrane ; Single-pass type I membrane protein Belongs to the peptidase S1 family. Sequence=BAB24725.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc007uie.1 uc007uie.2 uc007uie.3 
ENSMUST00000022538.5 Mrpl57 ENSMUST00000022538.5 mitochondrial ribosomal protein L57 (from RefSeq NM_026401.2) ENSMUST00000022538.1 ENSMUST00000022538.2 ENSMUST00000022538.3 ENSMUST00000022538.4 Mrp63 NM_026401 Q9CQF8 RT63_MOUSE uc007udq.1 uc007udq.2 uc007udq.3 Mitochondrion Identified only in the intact 55S subunit. It is unknown whether it belongs to the 28S or to the 39S subunit. May localize at the subunit interface and dissociate from the 55S mitoribosome during subunit separation. Belongs to the mitochondrion-specific ribosomal protein mL63 family. structural constituent of ribosome mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit ribosome translation mitochondrial translation uc007udq.1 uc007udq.2 uc007udq.3 
ENSMUST00000022543.10 Micu2 ENSMUST00000022543.10 mitochondrial calcium uptake 2, transcript variant 4 (from RefSeq NR_184778.1) ENSMUST00000022543.1 ENSMUST00000022543.2 ENSMUST00000022543.3 ENSMUST00000022543.4 ENSMUST00000022543.5 ENSMUST00000022543.6 ENSMUST00000022543.7 ENSMUST00000022543.8 ENSMUST00000022543.9 Efha1 MICU2_MOUSE NR_184778 Q3TJU4 Q8CD10 Q8K0K2 Q9CUR8 uc007udv.1 uc007udv.2 uc007udv.3 Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:23409044, PubMed:24560927). MICU1 and MICU2 form a disulfide- linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering (PubMed:24560927). Heterodimer; disulfide-linked; heterodimerizes with MICU1 (PubMed:23409044, PubMed:24560927). Interacts with MCU (PubMed:23409044). The heterodimer formed with MICU1 associates with MCU at low calcium concentration and dissociates from MCU at high calcium level (By similarity). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1. Mitochondrion intermembrane space Predominantly expressed in stomach, intestine, skeletal muscle, kidney, heart, testis, prostate and uterus. The EF-hand domains have high affinity for calcium and act as sensors of mitochondrial matrix calcium levels (PubMed:24560927). It is unclear which EF-hand binds calcium as none of the 4 EF-hand domains seem to contain a canonical calcium-binding site. Belongs to the MICU1 family. MICU2 subfamily. calcium ion binding protein binding mitochondrion mitochondrial inner membrane mitochondrial intermembrane space mitochondrial calcium ion transport calcium channel complex mitochondrial calcium uptake protein heterodimerization activity mitochondrial calcium ion homeostasis positive regulation of mitochondrial calcium ion concentration negative regulation of mitochondrial calcium ion concentration uniplex complex uc007udv.1 uc007udv.2 uc007udv.3 
ENSMUST00000022545.14 Fgf9 ENSMUST00000022545.14 fibroblast growth factor 9, transcript variant 1 (from RefSeq NM_013518.5) ENSMUST00000022545.1 ENSMUST00000022545.10 ENSMUST00000022545.11 ENSMUST00000022545.12 ENSMUST00000022545.13 ENSMUST00000022545.2 ENSMUST00000022545.3 ENSMUST00000022545.4 ENSMUST00000022545.5 ENSMUST00000022545.6 ENSMUST00000022545.7 ENSMUST00000022545.8 ENSMUST00000022545.9 FGF9_MOUSE Fgf-9 NM_013518 P54130 Q499I9 uc007udx.1 uc007udx.2 uc007udx.3 uc007udx.4 Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity). Secreted. Belongs to the heparin-binding growth factors family. negative regulation of transcription from RNA polymerase II promoter angiogenesis osteoblast differentiation eye development positive regulation of mesenchymal cell proliferation chondrocyte differentiation cardiac left ventricle morphogenesis cardiac ventricle development fibroblast growth factor receptor binding extracellular region basement membrane extracellular space cytoplasm protein import into nucleus cell-cell signaling multicellular organism development growth factor activity heparin binding positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway male gonad development positive regulation of gene expression cell differentiation negative regulation of Wnt signaling pathway male sex determination lung development embryonic limb morphogenesis positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of activin receptor signaling pathway inner ear morphogenesis positive regulation of MAPK cascade positive regulation of smoothened signaling pathway positive regulation of transcription, DNA-templated regulation of timing of cell differentiation embryonic digestive tract development embryonic skeletal system development positive regulation of epithelial cell proliferation positive regulation of cell division positive regulation of cardiac muscle cell proliferation lung-associated mesenchyme development vasculogenesis involved in coronary vascular morphogenesis positive regulation of canonical Wnt signaling pathway positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration uc007udx.1 uc007udx.2 uc007udx.3 uc007udx.4 
ENSMUST00000022548.10 1700129C05Rik ENSMUST00000022548.10 RIKEN cDNA 1700129C05 gene, transcript variant 1 (from RefSeq NM_026461.2) 1700129C05Rik ENSMUST00000022548.1 ENSMUST00000022548.2 ENSMUST00000022548.3 ENSMUST00000022548.4 ENSMUST00000022548.5 ENSMUST00000022548.6 ENSMUST00000022548.7 ENSMUST00000022548.8 ENSMUST00000022548.9 NM_026461 Q9CQ77 Q9CQ77_MOUSE uc007udz.1 uc007udz.2 uc007udz.3 molecular_function cellular_component biological_process uc007udz.1 uc007udz.2 uc007udz.3 
ENSMUST00000022550.8 Extl3 ENSMUST00000022550.8 exostosin-like glycosyltransferase 3, transcript variant 1 (from RefSeq NM_018788.4) ENSMUST00000022550.1 ENSMUST00000022550.2 ENSMUST00000022550.3 ENSMUST00000022550.4 ENSMUST00000022550.5 ENSMUST00000022550.6 ENSMUST00000022550.7 Extl3 NM_018788 Q6P1H4 Q6P1H4_MOUSE uc007uix.1 uc007uix.2 uc007uix.3 uc007uix.4 Endoplasmic reticulum membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 47 family. endoplasmic reticulum Golgi apparatus protein glycosylation heparan sulfate proteoglycan biosynthetic process membrane integral component of membrane transferase activity, transferring glycosyl groups positive regulation of cell growth uc007uix.1 uc007uix.2 uc007uix.3 uc007uix.4 
ENSMUST00000022553.6 Cab39l ENSMUST00000022553.6 calcium binding protein 39-like, transcript variant 3 (from RefSeq NM_026908.4) CB39L_MOUSE ENSMUST00000022553.1 ENSMUST00000022553.2 ENSMUST00000022553.3 ENSMUST00000022553.4 ENSMUST00000022553.5 NM_026908 Q8BG52 Q91WB8 Q91YL0 Q9DB16 uc007uem.1 uc007uem.2 Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DB16-1; Sequence=Displayed; Name=2; IsoId=Q9DB16-2; Sequence=VSP_007417, VSP_007418; Belongs to the Mo25 family. Sequence=AAH16128.1; Type=Erroneous initiation; Evidence=; signal transduction by protein phosphorylation protein serine/threonine kinase activity uc007uem.1 uc007uem.2 
ENSMUST00000022561.9 Amer2 ENSMUST00000022561.9 APC membrane recruitment 2, transcript variant 1 (from RefSeq NM_028113.4) AMER2_MOUSE ENSMUST00000022561.1 ENSMUST00000022561.2 ENSMUST00000022561.3 ENSMUST00000022561.4 ENSMUST00000022561.5 ENSMUST00000022561.6 ENSMUST00000022561.7 ENSMUST00000022561.8 Fam123a NM_028113 Q7TNC5 Q8CCJ4 Q8K0U9 Q9D0Q2 uc011zmz.1 uc011zmz.2 uc011zmz.3 uc011zmz.4 Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity). Interacts with APC. Cell membrane ; Peripheral membrane protein Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CCJ4-1; Sequence=Displayed; Name=2; IsoId=Q8CCJ4-2; Sequence=VSP_024090; Belongs to the Amer family. Sequence=AAH30356.1; Type=Erroneous initiation; Evidence=; Sequence=AAH56350.1; Type=Erroneous initiation; Evidence=; Sequence=BAB27452.1; Type=Erroneous initiation; Evidence=; Sequence=BAC27972.1; Type=Erroneous initiation; Evidence=; Sequence=BAE23912.1; Type=Erroneous initiation; Evidence=; protein binding phosphatidylinositol-4,5-bisphosphate binding plasma membrane ectoderm development beta-catenin binding lipid binding membrane Wnt signaling pathway regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway uc011zmz.1 uc011zmz.2 uc011zmz.3 uc011zmz.4 
ENSMUST00000022563.9 Mtmr6 ENSMUST00000022563.9 myotubularin related protein 6, transcript variant 1 (from RefSeq NM_144843.5) ENSMUST00000022563.1 ENSMUST00000022563.2 ENSMUST00000022563.3 ENSMUST00000022563.4 ENSMUST00000022563.5 ENSMUST00000022563.6 ENSMUST00000022563.7 ENSMUST00000022563.8 L8AZD2 MTMR6_MOUSE Mtmr6 NM_144843 Q8VE11 uc007ufa.1 uc007ufa.2 uc007ufa.3 uc007ufa.4 Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (By similarity). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:39019, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57795, ChEBI:CHEBI:57923; EC=3.1.3.95; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3- phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5- bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:45632, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:78911, ChEBI:CHEBI:85342; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3- phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:42328, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:65221, ChEBI:CHEBI:78934; Evidence=; Allosterically activated by phosphatidylserine and/or phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P) (By similarity). Interaction with MTMR9 increases catalytic activity towards phosphatidylinositol 3,5-bisphosphate (By similarity). Homodimer (By similarity). Heterodimer (via C-terminus) with MTMR9 (via C-terminus) (PubMed:23188820, PubMed:12890864). Interacts with ALKBH4 (By similarity). Interacts with KCNN4 (By similarity). Interacts (via GRAM domain) with RAB1B (in GDP-bound form); the interaction regulates MTMR6 recruitment to the endoplasmic reticulum- Golgi intermediate compartment (PubMed:23188820). Cytoplasm Endoplasmic reticulum-Golgi intermediate compartment Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side Endoplasmic reticulum Note=Localizes to ruffles during EGF- induced macropinocytosis (PubMed:24591580). Colocalizes with MTMR9 to the perinuclear region (By similarity). Partially localizes to the endoplasmic reticulum (By similarity). Co-localizes with RAB1B to the endoplasmic reticulum-Golgi intermediate compartment and to the peri- Golgi region (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VE11-1; Sequence=Displayed; Name=2; IsoId=Q8VE11-2; Sequence=VSP_060069; Isoform 1: Ubiquitously expressed including in heart, brain, spleen, lung, liver, muscle, kidney and testis (at protein level) (PubMed:23188820). Isoform 2: Expressed in testis (at protein level) (PubMed:23188820). The GRAM domain is required for cell membrane localization. The C-terminus domain (aa 502-617) mediates interaction with MTMR9. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. phosphatidylinositol-3-phosphatase activity protein tyrosine phosphatase activity nuclear envelope cytoplasm endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment plasma membrane lipid metabolic process endocytosis calcium-activated potassium channel activity membrane dephosphorylation hydrolase activity ruffle membrane peptidyl-tyrosine dephosphorylation cell projection phosphatidylinositol dephosphorylation phosphatidylinositol phosphate phosphatase activity potassium ion transmembrane transport uc007ufa.1 uc007ufa.2 uc007ufa.3 uc007ufa.4 
ENSMUST00000022567.9 Cacna2d3 ENSMUST00000022567.9 calcium channel, voltage-dependent, alpha2/delta subunit 3 (from RefSeq NM_009785.1) CA2D3_MOUSE ENSMUST00000022567.1 ENSMUST00000022567.2 ENSMUST00000022567.3 ENSMUST00000022567.4 ENSMUST00000022567.5 ENSMUST00000022567.6 ENSMUST00000022567.7 ENSMUST00000022567.8 NM_009785 Q9Z1L5 uc288ruf.1 uc288ruf.2 The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q- type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G). Dimer formed of alpha-2-2 and delta-2 chains; disulfide- linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity). Membrane ; Single-pass type I membrane protein Brain-specific. Predominantly expressed in the caudate putamen, entorhinal complex, hippocampus and cortex. The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. N-glycosylated. May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role. In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug. Belongs to the calcium channel subunit alpha-2/delta family. voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity voltage-gated calcium channel complex ion transport calcium ion transport membrane integral component of membrane regulation of ion transmembrane transport metal ion binding calcium ion transmembrane transport uc288ruf.1 uc288ruf.2 
ENSMUST00000022573.17 Esd ENSMUST00000022573.17 esterase D/formylglutathione hydrolase, transcript variant 2 (from RefSeq NM_016903.5) ENSMUST00000022573.1 ENSMUST00000022573.10 ENSMUST00000022573.11 ENSMUST00000022573.12 ENSMUST00000022573.13 ENSMUST00000022573.14 ENSMUST00000022573.15 ENSMUST00000022573.16 ENSMUST00000022573.2 ENSMUST00000022573.3 ENSMUST00000022573.4 ENSMUST00000022573.5 ENSMUST00000022573.6 ENSMUST00000022573.7 ENSMUST00000022573.8 ENSMUST00000022573.9 ESTD_MOUSE Es10 NM_016903 Q80ZX4 Q9CWI4 Q9R0P3 Sid478 uc007uqd.1 uc007uqd.2 uc007uqd.3 Serine hydrolase involved in the detoxification of formaldehyde. Reaction=H2O + S-formylglutathione = formate + glutathione + H(+); Xref=Rhea:RHEA:14961, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:57688, ChEBI:CHEBI:57925; EC=3.1.2.12; Homodimer. Cytoplasm. Cytoplasmic vesicle Belongs to the esterase D family. Sequence=BAB27115.1; Type=Erroneous initiation; Evidence=; cytoplasm cytosol hydrolase activity hydrolase activity, acting on ester bonds S-formylglutathione hydrolase activity cytoplasmic vesicle identical protein binding formaldehyde catabolic process carboxylic ester hydrolase activity uc007uqd.1 uc007uqd.2 uc007uqd.3 
ENSMUST00000022574.5 Lrrc63 ENSMUST00000022574.5 leucine rich repeat containing 63, transcript variant 1 (from RefSeq NM_027581.2) A6H694 ENSMUST00000022574.1 ENSMUST00000022574.2 ENSMUST00000022574.3 ENSMUST00000022574.4 G3X8V0 LRC63_MOUSE Lrrc63 NM_027581 Q9D5X5 uc007uql.1 uc007uql.2 uc007uql.3 uc007uql.4 Sequence=BAB29582.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc007uql.1 uc007uql.2 uc007uql.3 uc007uql.4 
ENSMUST00000022576.10 Cpb2 ENSMUST00000022576.10 carboxypeptidase B2 (from RefSeq NM_019775.3) CBPB2_MOUSE ENSMUST00000022576.1 ENSMUST00000022576.2 ENSMUST00000022576.3 ENSMUST00000022576.4 ENSMUST00000022576.5 ENSMUST00000022576.6 ENSMUST00000022576.7 ENSMUST00000022576.8 ENSMUST00000022576.9 NM_019775 Q5EBI3 Q9JHH6 Q9QZF0 Tafi uc007uqq.1 uc007uqq.2 uc007uqq.3 uc007uqq.4 This gene encodes carboxypeptidase B, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme, and secreted into plasma. [provided by RefSeq, Jan 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF164524.1, BC089577.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. Reaction=Release of C-terminal Arg and Lys from a polypeptide.; EC=3.4.17.20; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; TAFI/CPB2 is unique among carboxypeptidases in that it spontaneously inactivates with a short half-life, a property that is crucial for its role in controlling blood clot lysis. The zymogen is stabilized by interactions with the activation peptide. Release of the activation peptide increases a dynamic flap mobility and in time this leads to conformational changes that disrupt the catalytic site and expose a cryptic thrombin-cleavage site present at Arg-323 (By similarity). Secreted Plasma; synthesized in the liver. Belongs to the peptidase M14 family. positive regulation of extracellular matrix constituent secretion carboxypeptidase activity metallocarboxypeptidase activity extracellular region extracellular space cell proteolysis blood coagulation hemostasis peptidase activity metallopeptidase activity zinc ion binding response to heat negative regulation of plasminogen activation hydrolase activity response to drug fibrinolysis metal ion binding negative regulation of fibrinolysis cellular response to glucose stimulus liver regeneration negative regulation of hepatocyte proliferation uc007uqq.1 uc007uqq.2 uc007uqq.3 uc007uqq.4 
ENSMUST00000022577.6 Zc3h13 ENSMUST00000022577.6 zinc finger CCCH type containing 13, transcript variant 2 (from RefSeq NM_026083.2) B9EHN9 E9Q784 ENSMUST00000022577.1 ENSMUST00000022577.2 ENSMUST00000022577.3 ENSMUST00000022577.4 ENSMUST00000022577.5 NM_026083 ZC3HD_MOUSE Zc3h13 uc007uqs.1 uc007uqs.2 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (PubMed:29547716). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (PubMed:29547716). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (PubMed:29547716). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (PubMed:29535189). Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:29535189, PubMed:29547716). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:29535189, PubMed:29547716). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29535189, PubMed:29547716). Also a component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, RBM15, BCLAF1 and THRAP3 (By similarity). Nucleus speckle Nucleus, nucleoplasm Belongs to the ZC3H13 family. nucleus nucleoplasm mRNA processing multicellular organism development RNA splicing nuclear speck MIS complex metal ion binding mRNA methylation regulation of stem cell population maintenance uc007uqs.1 uc007uqs.2 
ENSMUST00000022580.8 Slc25a30 ENSMUST00000022580.8 solute carrier family 25, member 30 (from RefSeq NM_026232.3) ENSMUST00000022580.1 ENSMUST00000022580.2 ENSMUST00000022580.3 ENSMUST00000022580.4 ENSMUST00000022580.5 ENSMUST00000022580.6 ENSMUST00000022580.7 KMCP1_MOUSE Kmcp1 NM_026232 Q3UAD0 Q9CR58 Slc25a30 uc007uqx.1 uc007uqx.2 uc007uqx.3 Antiporter that transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate. The sulfate/sulfate exchange is much higher than the phosphate/phosphate and malate/malate exchanges. The transport affinities is higher for sulfate and thiosulfate than for any other substrate. May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide. Also may mediate a very low unidirectional transport of sulfate, phosphate and (S)-malate. Reaction=sulfate(out) + sulfite(in) = sulfate(in) + sulfite(out); Xref=Rhea:RHEA:73207, ChEBI:CHEBI:16189, ChEBI:CHEBI:17359; Evidence=; Reaction=sulfate(out) + thiosulfate(in) = sulfate(in) + thiosulfate(out); Xref=Rhea:RHEA:73215, ChEBI:CHEBI:16189, ChEBI:CHEBI:33542; Evidence=; Reaction=phosphate(in) + sulfate(out) = phosphate(out) + sulfate(in); Xref=Rhea:RHEA:71631, ChEBI:CHEBI:16189, ChEBI:CHEBI:43474; Evidence=; Reaction=oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in); Xref=Rhea:RHEA:72275, ChEBI:CHEBI:16189, ChEBI:CHEBI:30623; Evidence=; Reaction=malonate(in) + sulfate(out) = malonate(out) + sulfate(in); Xref=Rhea:RHEA:73195, ChEBI:CHEBI:15792, ChEBI:CHEBI:16189; Evidence=; Reaction=maleate(in) + sulfate(out) = maleate(out) + sulfate(in); Xref=Rhea:RHEA:73199, ChEBI:CHEBI:16189, ChEBI:CHEBI:30780; Evidence=; Reaction=(S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in); Xref=Rhea:RHEA:71615, ChEBI:CHEBI:15589, ChEBI:CHEBI:16189; Evidence=; Reaction=(3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in); Xref=Rhea:RHEA:73223, ChEBI:CHEBI:16189, ChEBI:CHEBI:30936; Evidence=; Reaction=(3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in); Xref=Rhea:RHEA:73227, ChEBI:CHEBI:16189, ChEBI:CHEBI:30934; Evidence=; Reaction=succinate(in) + sulfate(out) = succinate(out) + sulfate(in); Xref=Rhea:RHEA:73411, ChEBI:CHEBI:16189, ChEBI:CHEBI:30031; Evidence=; Reaction=(S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in); Xref=Rhea:RHEA:73407, ChEBI:CHEBI:16189, ChEBI:CHEBI:30927; Evidence=; Reaction=(2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in); Xref=Rhea:RHEA:73403, ChEBI:CHEBI:16189, ChEBI:CHEBI:30924; Evidence=; Reaction=D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in); Xref=Rhea:RHEA:73399, ChEBI:CHEBI:16189, ChEBI:CHEBI:29990; Evidence=; Reaction=L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in); Xref=Rhea:RHEA:73395, ChEBI:CHEBI:16189, ChEBI:CHEBI:29991; Evidence=; Reaction=sulfate(in) = sulfate(out); Xref=Rhea:RHEA:34983, ChEBI:CHEBI:16189; Evidence=; Reaction=phosphate(in) = phosphate(out); Xref=Rhea:RHEA:32823, ChEBI:CHEBI:43474; Evidence=; Reaction=(S)-malate(out) = (S)-malate(in); Xref=Rhea:RHEA:74555, ChEBI:CHEBI:15589; Evidence=; Interacts with VDAC1. Mitochondrion inner membrane ; Multi-pass membrane protein Present in kidney (at protein level). Expressed predominantly within the kidney cortex in the proximal and distal tubules and at lower levels in the testis and white adipose tissue. Up-regulated during fasting and in the regenerative phase following renal tubular injury. Belongs to the mitochondrial carrier (TC 2.A.29) family. mitochondrion mitochondrial inner membrane membrane integral component of membrane transmembrane transporter activity transmembrane transport uc007uqx.1 uc007uqx.2 uc007uqx.3 
ENSMUST00000022585.5 Gpalpp1 ENSMUST00000022585.5 GPALPP motifs containing 1 (from RefSeq NM_026177.3) ENSMUST00000022585.1 ENSMUST00000022585.2 ENSMUST00000022585.3 ENSMUST00000022585.4 GPAM1_MOUSE Kiaa1704 NM_026177 Q69ZC8 Q8K2V8 uc007urd.1 uc007urd.2 uc007urd.3 Sequence=BAD32516.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process uc007urd.1 uc007urd.2 uc007urd.3 
ENSMUST00000022586.2 Nufip1 ENSMUST00000022586.2 nuclear FMR1 interacting protein 1, transcript variant 6 (from RefSeq NR_188814.1) ENSMUST00000022586.1 NR_188814 NUFP1_MOUSE Nufip1 Q9CV69 Q9QXX8 uc007ure.1 uc007ure.2 Binds RNA. Interacts with FMR1 (PubMed:10556305). Interacts with ZNHIT3 (By similarity). Nucleus Note=Distributed in the nucleus in a dot-like pattern. Expressed in the brain; in neurons and not in glial cells. box C/D snoRNP assembly fibrillar center nucleic acid binding RNA binding protein binding nucleus perichromatin fibrils nucleolus transcription elongation factor complex nuclear matrix cytosolic ribosome snoRNA binding protein binding, bridging macromolecular complex identical protein binding synapse positive regulation of transcription from RNA polymerase II promoter metal ion binding presynaptic active zone ATPase binding protein oligomerization pre-snoRNP complex uc007ure.1 uc007ure.2 
ENSMUST00000022587.10 Tsc22d1 ENSMUST00000022587.10 TSC22 domain family, member 1, transcript variant 2 (from RefSeq NM_009366.4) ENSMUST00000022587.1 ENSMUST00000022587.2 ENSMUST00000022587.3 ENSMUST00000022587.4 ENSMUST00000022587.5 ENSMUST00000022587.6 ENSMUST00000022587.7 ENSMUST00000022587.8 ENSMUST00000022587.9 NM_009366 Q3UXU0 Q3UXU0_MOUSE Tsc22d1 uc007urk.1 uc007urk.2 uc007urk.3 uc007urk.4 uc007urk.5 Belongs to the TSC-22/Dip/Bun family. transcription factor activity, sequence-specific DNA binding regulation of transcription, DNA-templated uc007urk.1 uc007urk.2 uc007urk.3 uc007urk.4 uc007urk.5 
ENSMUST00000022589.9 Enox1 ENSMUST00000022589.9 ecto-NOX disulfide-thiol exchanger 1, transcript variant 2 (from RefSeq NM_172813.3) ENOX1_MOUSE ENSMUST00000022589.1 ENSMUST00000022589.2 ENSMUST00000022589.3 ENSMUST00000022589.4 ENSMUST00000022589.5 ENSMUST00000022589.6 ENSMUST00000022589.7 ENSMUST00000022589.8 NM_172813 Q80WS5 Q8BHR2 uc007urw.1 uc007urw.2 uc007urw.3 uc007urw.4 Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock (By similarity). Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Not inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, and retinoids. Cell membrane Secreted, extracellular space Note=Extracellular and plasma membrane-associated. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BHR2-1; Sequence=Displayed; Name=2; IsoId=Q8BHR2-2; Sequence=VSP_027122; Belongs to the ENOX family. molecular_function nucleic acid binding extracellular region extracellular space plasma membrane ultradian rhythm biological_process external side of plasma membrane membrane oxidoreductase activity rhythmic process oxidation-reduction process uc007urw.1 uc007urw.2 uc007urw.3 uc007urw.4 
ENSMUST00000022591.16 Epsti1 ENSMUST00000022591.16 epithelial stromal interaction 1, transcript variant a (from RefSeq NM_029495.2) A0A140T8I6 A0A140T8I6_MOUSE ENSMUST00000022591.1 ENSMUST00000022591.10 ENSMUST00000022591.11 ENSMUST00000022591.12 ENSMUST00000022591.13 ENSMUST00000022591.14 ENSMUST00000022591.15 ENSMUST00000022591.2 ENSMUST00000022591.3 ENSMUST00000022591.4 ENSMUST00000022591.5 ENSMUST00000022591.6 ENSMUST00000022591.7 ENSMUST00000022591.8 ENSMUST00000022591.9 Epsti1 NM_029495 uc007use.1 uc007use.2 uc007use.3 uc007use.4 uc007use.1 uc007use.2 uc007use.3 uc007use.4 
ENSMUST00000022592.8 Tnfsf11 ENSMUST00000022592.8 tumor necrosis factor (ligand) superfamily, member 11 (from RefSeq NM_011613.4) ENSMUST00000022592.1 ENSMUST00000022592.2 ENSMUST00000022592.3 ENSMUST00000022592.4 ENSMUST00000022592.5 ENSMUST00000022592.6 ENSMUST00000022592.7 NM_011613 O35235 O35306 Opgl Q3TWY5 Q9JJK8 Q9JJK9 Q9R1Y0 Rankl TNF11_MOUSE Trance uc007ush.1 uc007ush.2 uc007ush.3 Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor (PubMed:22437732). Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T- cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (By similarity). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts (PubMed:18586671, PubMed:24039232, PubMed:27336669). During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (PubMed:23395171, PubMed:26644563). Homotrimer (PubMed:11581298, PubMed:11733492, PubMed:20483727). Interacts with TNFRSF11A and TNFRSF11B (PubMed:20483727, PubMed:23039992). Interacts with FBN1 (via N-terminal domain) in a Ca(+2)-dependent manner (PubMed:24039232). Interacts with TNFAIP6 (via both Link and CUB domains). O35235-1; O35305: Tnfrsf11a; NbExp=6; IntAct=EBI-15890886, EBI-647362; O35235-1; O08712: Tnfrsf11b; NbExp=4; IntAct=EBI-15890886, EBI-16015871; [Isoform 1]: Cell membrane; Single-pass type II membrane protein. [Isoform 2]: Cell membrane; Single-pass type II membrane protein. [Isoform 3]: Cytoplasm. [Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O35235-1; Sequence=Displayed; Name=2; IsoId=O35235-2; Sequence=VSP_006449; Name=3; IsoId=O35235-3; Sequence=VSP_006448; Highly expressed in thymus and lymph nodes, but not in non-lymphoid tissues and is abundantly expressed in T-cells but not in B-cells. A high level expression is also seen in the trabecular bone and lung. N-glycosylated. The soluble form of isoform 1 derives from the membrane form by proteolytic processing. The cleavage may be catalyzed by ADAM17. A further shorter soluble form was observed. Note=Deficiency in Tnfsf11 results in failure to form lobulo- alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes. Belongs to the tumor necrosis factor family. ossification osteoclast proliferation monocyte chemotaxis cytokine activity tumor necrosis factor receptor binding protein binding extracellular region extracellular space cytoplasm plasma membrane immune response activation of JUN kinase activity multicellular organism development animal organ morphogenesis positive regulation of gene expression membrane integral component of membrane cytokine-mediated signaling pathway calcium-mediated signaling cell differentiation osteoclast differentiation tumor necrosis factor receptor superfamily binding tumor necrosis factor-mediated signaling pathway mammary gland epithelial cell proliferation positive regulation of homotypic cell-cell adhesion osteoclast development paracrine signaling positive regulation of phosphorylation identical protein binding positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAP kinase activity tooth eruption bone resorption regulation of osteoclast differentiation positive regulation of osteoclast differentiation positive regulation of bone resorption positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade lymph node development positive regulation of T cell activation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of corticotropin-releasing hormone secretion positive regulation of protein kinase B signaling calcium ion homeostasis bone development mammary gland alveolus development ERK1 and ERK2 cascade positive regulation of fever generation by positive regulation of prostaglandin secretion TNFSF11-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling positive regulation of intracellular signal transduction regulation of actin binding cellular response to leukemia inhibitory factor positive regulation of osteoclast development uc007ush.1 uc007ush.2 uc007ush.3 
ENSMUST00000022595.8 Rgcc ENSMUST00000022595.8 regulator of cell cycle (from RefSeq NM_025427.2) ENSMUST00000022595.1 ENSMUST00000022595.2 ENSMUST00000022595.3 ENSMUST00000022595.4 ENSMUST00000022595.5 ENSMUST00000022595.6 ENSMUST00000022595.7 NM_025427 Q9D0U0 Q9DBX1 RGCC_MOUSE Rgc32 uc007ust.1 uc007ust.2 uc007ust.3 Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. Interacts with CDK1 and PLK1 (By similarity). Interacts with SMAD3. Cytoplasm Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase (By similarity). G1/S transition of mitotic cell cycle negative regulation of exit from mitosis negative regulation of endothelial cell proliferation positive regulation of extracellular matrix constituent secretion protein binding nucleus nucleolus cytoplasm centrosome microtubule organizing center cytoskeleton complement activation cell cycle negative regulation of cell proliferation positive regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of angiogenesis protein kinase binding protein kinase activator activity activation of protein kinase activity positive regulation of collagen biosynthetic process negative regulation of blood vessel endothelial cell migration positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter negative regulation of cytokine secretion positive regulation of cytokine secretion positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of stress fiber assembly regulation of cell cycle R-SMAD binding positive regulation of cell cycle arrest cellular response to hypoxia mitotic cell cycle arrest fibroblast activation negative regulation of fibroblast growth factor production positive regulation of G1/S transition of mitotic cell cycle positive regulation of extracellular matrix assembly negative regulation of mitotic cell cycle phase transition negative regulation of cell-cell adhesion mediated by cadherin positive regulation of endothelial cell apoptotic process positive regulation of DNA biosynthetic process uc007ust.1 uc007ust.2 uc007ust.3 
ENSMUST00000022597.15 Naa16 ENSMUST00000022597.15 N(alpha)-acetyltransferase 16, NatA auxiliary subunit (from RefSeq NM_025832.2) ENSMUST00000022597.1 ENSMUST00000022597.10 ENSMUST00000022597.11 ENSMUST00000022597.12 ENSMUST00000022597.13 ENSMUST00000022597.14 ENSMUST00000022597.2 ENSMUST00000022597.3 ENSMUST00000022597.4 ENSMUST00000022597.5 ENSMUST00000022597.6 ENSMUST00000022597.7 ENSMUST00000022597.8 ENSMUST00000022597.9 NAA16_MOUSE NM_025832 Narg1l Nat2 Q3U7V2 Q9DBB4 uc007usv.1 uc007usv.2 uc007usv.3 Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 and NAA16. Highest levels in the kidney and testes. Moderate expression in the liver, thymus and skin. peptide alpha-N-acetyltransferase activity cytoplasm cytosol N-terminal protein amino acid acetylation N-terminal peptidyl-methionine acetylation NatA complex ribosome binding negative regulation of apoptotic process protein stabilization uc007usv.1 uc007usv.2 uc007usv.3 
ENSMUST00000022600.4 Mtrf1 ENSMUST00000022600.4 mitochondrial translational release factor 1 (from RefSeq NM_145960.4) ENSMUST00000022600.1 ENSMUST00000022600.2 ENSMUST00000022600.3 Mtrf1 NM_145960 Q8K126 RF1M_MOUSE uc007usx.1 uc007usx.2 uc007usx.3 uc007usx.4 Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non- canonical stop codons AGG and AGA. Non-canonical termination codons AGG and AGA are found at the end of MT-CO1/COX1 and MT-ND6/ND6 open reading frames, respectively. Recognizes non-canonical stop codons via a network of interactions between the codon, MTRF1 and the ribosomal RNA (rRNA): in contrast to other translation release factors, which identify the codon in the A-site via direct interactions of amino acid side chains with the bases, MTRF1 repositions the first 2 bases of the stop codon to use an intricate network of interactions that includes residues of the release factor, the rRNA of the small ribosomal subunit, as well as neighboring bases of the mRNA. Mitochondrion The GGQ domain interacts with the peptidyltransferase center (PTC) of the large ribosomal subunit to trigger nascent chain hydrolysis. Methylation of glutamine in the GGQ triplet by HEMK1 is conserved from bacteria to mammals. Belongs to the prokaryotic/mitochondrial release factor family. translation release factor activity mitochondrion translation translational termination translation release factor activity, codon specific ribosome binding mitochondrial translational termination uc007usx.1 uc007usx.2 uc007usx.3 uc007usx.4 
ENSMUST00000022601.7 Wbp4 ENSMUST00000022601.7 WW domain binding protein 4 (from RefSeq NM_018765.3) ENSMUST00000022601.1 ENSMUST00000022601.2 ENSMUST00000022601.3 ENSMUST00000022601.4 ENSMUST00000022601.5 ENSMUST00000022601.6 Fbp21 Fnbp21 NM_018765 Q3TUU8 Q61048 Q8K1Z9 Q9CS45 WBP4_MOUSE uc007uta.1 uc007uta.2 uc007uta.3 Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex. Component of the spliceosome B complex (PubMed:9724750). Associated with U2 snRNPs. Binds splicing factors SNRPB, SNRPC and SF1 (PubMed:9724750). Interacts via the WW domains with the Pro-rich domains of KHDRBS1/SAM68 (PubMed:10748127). Interacts via the WW domains with the Pro-rich domains of WBP11 (By similarity). Interacts with SNRNP200 (By similarity). Nucleus Nucleus speckle The WW domain recognizes the proline, glycine and methionine- rich (PGM) motif present in the splicing factors, as well as the Arg/Gly-rich-flanked Pro-rich domains found in several WW domain- binding proteins. mRNA splicing, via spliceosome nucleic acid binding protein binding nucleus spliceosomal complex mRNA processing zinc ion binding RNA splicing nuclear speck mRNA cis splicing, via spliceosome metal ion binding proline-rich region binding U2-type precatalytic spliceosome uc007uta.1 uc007uta.2 uc007uta.3 
ENSMUST00000022603.8 Cnmd ENSMUST00000022603.8 chondromodulin, transcript variant 2 (from RefSeq NM_010701.4) CNMD_MOUSE Chmi Cnmd ENSMUST00000022603.1 ENSMUST00000022603.2 ENSMUST00000022603.3 ENSMUST00000022603.4 ENSMUST00000022603.5 ENSMUST00000022603.6 ENSMUST00000022603.7 Lect1 NM_010701 Q80UX1 Q9CXU5 Q9Z1F6 uc007utg.1 uc007utg.2 uc007utg.3 uc007utg.4 uc007utg.5 Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development (By similarity). Inhibits in vitro tube formation and mobilization of endothelial cells (By similarity). Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. [Chondromodulin-1]: Secreted, extracellular space, extracellular matrix Note=Accumulated in the inter-territorial matrix of cartilage. [Chondrosurfactant protein]: Endomembrane system ; Single-pass membrane protein Detected in the four cardiac valves, valvular interstitial cells and extracellular matrix (at protein level). Detected from 9.5 dpc in the cardiac valve precursor cells from the atrioventricular cushions and outflow. At 10 dpc expressed in the cardiac jelly covering the trabeculating cardiomyocytes of the left ventricle, the outer curvature of the right ventricle and the outflow tract. Expression in the ventricles decreased gradually as development progressed, and disappeared by mid- embryogenesis (at protein level). After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein. Aged mice show enhanced VEGFA expression, angiogenesis, inflammatory cell infiltration, aortic stenosis, lipid deposition and calcification in the cardiac valves. Belongs to the chondromodulin-1 family. endothelial cell morphogenesis negative regulation of endothelial cell proliferation extracellular region multicellular organism development endomembrane system membrane integral component of membrane negative regulation of angiogenesis cell differentiation negative regulation of vascular endothelial growth factor receptor signaling pathway cartilage development uc007utg.1 uc007utg.2 uc007utg.3 uc007utg.4 uc007utg.5 
ENSMUST00000022610.15 Scara5 ENSMUST00000022610.15 scavenger receptor class A, member 5, transcript variant 1 (from RefSeq NM_028903.2) ENSMUST00000022610.1 ENSMUST00000022610.10 ENSMUST00000022610.11 ENSMUST00000022610.12 ENSMUST00000022610.13 ENSMUST00000022610.14 ENSMUST00000022610.2 ENSMUST00000022610.3 ENSMUST00000022610.4 ENSMUST00000022610.5 ENSMUST00000022610.6 ENSMUST00000022610.7 ENSMUST00000022610.8 ENSMUST00000022610.9 NM_028903 Q8BZZ2 Q8K299 Q8R330 Q91WD6 Q9CUC3 Q9D4G8 SCAR5_MOUSE Scara5 uc007ujn.1 uc007ujn.2 uc007ujn.3 Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Preferentially binds ferritin light chain (FTL) compared to heavy chain (FTH1). Homotrimer. Cell membrane ingle-pass type II membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K299-1; Sequence=Displayed; Name=2; IsoId=Q8K299-2; Sequence=VSP_023477, VSP_023478; Name=3; IsoId=Q8K299-3; Sequence=VSP_023476, VSP_023477, VSP_023478; Expressed in the testis, trachea, lung, bladder and small intestine; especially in epithelial cells associated with mucosal surfaces. Belongs to the SCARA5 family. scavenger receptor activity protein binding plasma membrane integral component of plasma membrane ion transport cellular iron ion homeostasis endocytosis cell surface membrane integral component of membrane endocytic vesicle membrane cellular response to heat iron ion transmembrane transport iron ion homeostasis protein homotrimerization ferritin receptor activity uc007ujn.1 uc007ujn.2 uc007ujn.3 
ENSMUST00000022612.10 Pbk ENSMUST00000022612.10 PDZ binding kinase, transcript variant 1 (from RefSeq NM_023209.3) ENSMUST00000022612.1 ENSMUST00000022612.2 ENSMUST00000022612.3 ENSMUST00000022612.4 ENSMUST00000022612.5 ENSMUST00000022612.6 ENSMUST00000022612.7 ENSMUST00000022612.8 ENSMUST00000022612.9 NM_023209 Q922V2 Q9D184 Q9JJ78 TOPK_MOUSE Topk uc007ujo.1 uc007ujo.2 uc007ujo.3 Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2; Activated by phosphorylation. Interacts with DLG1 and TP53. Phosphorylated; in a cell-cycle dependent manner at mitosis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. nucleotide binding mitotic cell cycle negative regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity ATP binding nucleus protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation negative regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of stress-activated MAPK cascade cellular response to UV negative regulation of inflammatory response uc007ujo.1 uc007ujo.2 uc007ujo.3 
ENSMUST00000022613.10 Esco2 ENSMUST00000022613.10 establishment of sister chromatid cohesion N-acetyltransferase 2 (from RefSeq NM_028039.2) ENSMUST00000022613.1 ENSMUST00000022613.2 ENSMUST00000022613.3 ENSMUST00000022613.4 ENSMUST00000022613.5 ENSMUST00000022613.6 ENSMUST00000022613.7 ENSMUST00000022613.8 ENSMUST00000022613.9 ESCO2_MOUSE NM_028039 Q3UMT6 Q6IQX5 Q8BNG9 Q8BQF8 Q8CIB9 Q9CRI8 uc007ujp.1 uc007ujp.2 uc007ujp.3 uc007ujp.4 Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3. Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; Evidence=; Nucleus Chromosome Note=Nuclear in interphase cells, excluded from chromosomes during metaphase but reassociates with chromosomes in telophase. At 14.5 dpc the expression is detected in developing murine lip, eyelid, palate, digit, tongue and hair follicles. Its expression is also observed in the long bones of the developing forelimb but not the hindlimb. The N-terminal region seems to be responsible for association with chromosomes, thus excluding any involvement of the Zn finger in this process. Belongs to the acetyltransferase family. ECO subfamily. Sequence=BAB26905.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; chromatin XY body hematopoietic progenitor cell differentiation lysine N-acetyltransferase activity, acting on acetyl phosphate as donor nucleus chromosome Golgi apparatus regulation of DNA replication double-strand break repair cell cycle chromosome segregation sister chromatid cohesion chromocenter acetyltransferase activity transferase activity transferase activity, transferring acyl groups cell junction nuclear pericentric heterochromatin post-translational protein acetylation site of double-strand break metal ion binding protein localization to chromatin uc007ujp.1 uc007ujp.2 uc007ujp.3 uc007ujp.4 
ENSMUST00000022614.7 Ccdc25 ENSMUST00000022614.7 coiled-coil domain containing 25 (from RefSeq NM_145944.5) CCD25_MOUSE Ccdc25 ENSMUST00000022614.1 ENSMUST00000022614.2 ENSMUST00000022614.3 ENSMUST00000022614.4 ENSMUST00000022614.5 ENSMUST00000022614.6 NM_145944 Q78PG9 Q9CSQ8 Q9CUF8 uc007ujq.1 uc007ujq.2 uc007ujq.3 Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility. NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (By similarity). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (By similarity). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (By similarity). Interacts (via cytoplasmic region) with ILK. Cell membrane ; Single-pass membrane protein Endomembrane system Note=Localizes to cytoplasmic membrane in tumor cells. In the context of cancer, mice display reduced metastase formation, without affecting primary tumor growth. Belongs to the CCDC25 family. molecular_function biological_process uc007ujq.1 uc007ujq.2 uc007ujq.3 
ENSMUST00000022616.14 Clu ENSMUST00000022616.14 clusterin, transcript variant 1 (from RefSeq NM_013492.4) Clu ENSMUST00000022616.1 ENSMUST00000022616.10 ENSMUST00000022616.11 ENSMUST00000022616.12 ENSMUST00000022616.13 ENSMUST00000022616.2 ENSMUST00000022616.3 ENSMUST00000022616.4 ENSMUST00000022616.5 ENSMUST00000022616.6 ENSMUST00000022616.7 ENSMUST00000022616.8 ENSMUST00000022616.9 NM_013492 Q549A5 Q549A5_MOUSE uc007ujs.1 uc007ujs.2 uc007ujs.3 uc007ujs.4 uc007ujs.5 The protein encoded by this gene is a secreted chaperone that can, under some stress conditions, also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric mature protein comprised of alpha and beta subunits. Mice lacking the encoded protein exhibit increased severity of autoimmune myocarditis, faster progression of the acute inflammation to myocardial scarring and decreased brain injury following neonatal hypoxic-ischemic injury. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L05670.1, SRR1660817.34394.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers. Cytoplasm, cytosol Cytoplasm, perinuclear region Cytoplasmic vesicle, secretory vesicle, chromaffin granule Endoplasmic reticulum Membrane ; Peripheral membrane protein ; Cytoplasmic side Microsome Mitochondrion membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus Secreted Belongs to the clusterin family. cell morphogenesis beta-amyloid binding microglial cell activation receptor binding extracellular region extracellular space nucleus cytoplasm mitochondrion mitochondrial inner membrane cytosol cytoskeleton response to virus cell surface membrane protein import negative regulation of protein complex assembly positive regulation of protein complex assembly ubiquitin protein ligase binding central nervous system myelin maintenance positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of tumor necrosis factor production macromolecular complex spherical high-density lipoprotein particle regulation of cell proliferation intracellular membrane-bounded organelle macromolecular complex binding positive regulation of nitric oxide biosynthetic process tau protein binding positive regulation of receptor-mediated endocytosis perinuclear region of cytoplasm low-density lipoprotein particle receptor binding protein stabilization unfolded protein binding positive regulation of NF-kappaB transcription factor activity chaperone-mediated protein complex assembly misfolded protein binding response to misfolded protein negative regulation of cell death chaperone-mediated protein folding microglial cell proliferation cell periphery neurofibrillary tangle apical dendrite perinuclear endoplasmic reticulum lumen regulation of beta-amyloid clearance regulation of neuron death positive regulation of neuron death negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of beta-amyloid formation regulation of neuronal signal transduction positive regulation of tau-protein kinase activity positive regulation of neurofibrillary tangle assembly negative regulation of response to endoplasmic reticulum stress positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc007ujs.1 uc007ujs.2 uc007ujs.3 uc007ujs.4 uc007ujs.5 
ENSMUST00000022618.6 Adam2 ENSMUST00000022618.6 a disintegrin and metallopeptidase domain 2 (from RefSeq NM_009618.4) ADAM2_MOUSE Adam2 ENSMUST00000022618.1 ENSMUST00000022618.2 ENSMUST00000022618.3 ENSMUST00000022618.4 ENSMUST00000022618.5 Ftnb NM_009618 Q60718 Q60814 Q9D4G3 Q9QWJ0 uc007uju.1 uc007uju.2 uc007uju.3 uc007uju.4 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is predominantly expressed in the epididymis, where the encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Male mice lacking the encoded protein are infertile and exhibit multiple defects in reproduction. [provided by RefSeq, May 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK161266.1, U38806.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). Heterodimer with ADAM1/fertilin subunit alpha. Membrane; Single-pass type I membrane protein. Expressed in the testis and testicular sperm (at protein level). A tripeptide motif (QDE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding. The signal and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa. acrosomal vesicle metalloendopeptidase activity protein binding proteolysis cell adhesion single fertilization metallopeptidase activity visual learning cell surface positive regulation of gene expression membrane integral component of membrane adult behavior macromolecular complex uc007uju.1 uc007uju.2 uc007uju.3 uc007uju.4 
ENSMUST00000022622.14 Ptk2b ENSMUST00000022622.14 PTK2 protein tyrosine kinase 2 beta, transcript variant 1 (from RefSeq NM_001162366.2) B2RQ16 ENSMUST00000022622.1 ENSMUST00000022622.10 ENSMUST00000022622.11 ENSMUST00000022622.12 ENSMUST00000022622.13 ENSMUST00000022622.2 ENSMUST00000022622.3 ENSMUST00000022622.4 ENSMUST00000022622.5 ENSMUST00000022622.6 ENSMUST00000022622.7 ENSMUST00000022622.8 ENSMUST00000022622.9 FAK2_MOUSE Fak2 G3X8V1 NM_001162366 Pyk2 Q9QVP9 Raftk uc011znr.1 uc011znr.2 uc011znr.3 Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376' (By similarity). Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2 (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Activated in response to stimuli that lead to increased intracellular Ca(2+) levels; this activation is indirect and may be mediated by calcium-mediated production of reactive oxygen species (ROS). Activated by autophosphorylation at Tyr-402; this creates a binding site for SRC family kinases and leads to phosphorylation at additional tyrosine residues. Phosphorylation at Tyr-402, Tyr-579 and Tyr-580 is required for optimal kinase activity. Homodimer, or homooligomer. Interacts with KCNA2 (By similarity). Interacts with NPHP1, ASAP1, ASAP2, ARHGAP26, SKAP2 and TGFB1I1. The Tyr-402 phosphorylated form interacts with SRC (via SH2 domain) and SRC family members. Forms a signaling complex with EPHA1, LCK and phosphatidylinositol 3-kinase; upon activation by EFNA1. Interacts with GRB2 (via SH2 domain). Interacts with P53/TP53 and MDM2. Interacts with MYLK. Interacts with BCAR1. Interacts with RB1CC1. Interacts with RHOU. Interacts with VAV1. Interacts with PDPK1. Interacts with DLG4. Interacts with LPXN and PTPN12. Interacts with SIRPA and SH2D3C. Interacts (hypophosphorylated) with PXN. Interacts with ARHGAP10. Cytoplasm. Cytoplasm, perinuclear region Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Cell projection, lamellipodium Cytoplasm, cell cortex Nucleus Note=Colocalizes with integrins at the cell periphery (By similarity). Interaction with NPHP1 induces the membrane- association of the kinase. Colocalizes with PXN at the microtubule- organizing center. The tyrosine phosphorylated form is detected at cell-cell contacts. Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration; this activation is indirect and may be mediated by production of reactive oxygen species (ROS). Tyr-402 is the major autophosphorylation site, but other kinases can also phosphorylate Tyr-402. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-402 promotes interaction with SRC and SRC family members, leading to phosphorylation at Tyr-579; Tyr-580 and Tyr-881. Phosphorylation at Tyr-881 is important for interaction with GRB2. Phosphorylated on tyrosine residues upon activation of FGR and PKC. Recruitment by NPHP1 to cell matrix adhesions initiates Tyr-402 phosphorylation. In monocytes, adherence to substrata is required for tyrosine phosphorylation and kinase activation. Angiotensin II, thapsigargin and L-alpha- lysophosphatidic acid (LPA) also induce autophosphorylation and increase kinase activity. Phosphorylation by MYLK promotes ITGB2 activation and is thus essential to trigger neutrophil transmigration during lung injury. Dephosphorylated by PTPN12 (By similarity). Mice are born at the expected Mendelian rate, appear normal and are fertile. Mice display increased bone formation and high bone mass, due to defects in osteoclastic bone resorption. Osteoclasts display defects in actin cytoskeleton reorganization, plus altered Rho activity, microtubule stabilization and podosome organization. Mice also display increased differentiation and activity of osteoprogenitor cells. Macrophages from mutant mice display defects in their responses to chemokines, including defects in cell polarization, actin cytoskeleton reorganization, directed migration towards sites of inflammation, but also defects in the regulation of intracellular Ca(2+) levels, phosphatidylinositol 3-kinase activity and inositol 1,4,5-trisphosphate production. Mutant mice have normal B-cell polulations in bone marrow, lymph nodes and blood, but lack marginal zone B-cells in the spleen. Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily. MAPK cascade nucleotide binding response to reactive oxygen species angiogenesis oocyte maturation response to hypoxia positive regulation of cell-matrix adhesion sprouting angiogenesis adaptive immune response marginal zone B cell differentiation immune system process regulation of leukocyte chemotaxis protein kinase activity calmodulin-dependent protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity NMDA glutamate receptor activity protein binding ATP binding nucleus cytoplasm cytoskeleton plasma membrane focal adhesion cell cortex protein phosphorylation cellular defense response response to osmotic stress actin filament organization cell adhesion signal transduction cell surface receptor signaling pathway signal complex assembly epidermal growth factor receptor signaling pathway positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway protein C-terminus binding positive regulation of cell proliferation negative regulation of cell proliferation regulation of cell shape response to mechanical stimulus response to hormone response to glucose response to lithium ion response to organonitrogen compound positive regulation of endothelial cell migration negative regulation of muscle cell apoptotic process regulation of cGMP-mediated signaling regulation of macrophage chemotaxis positive regulation of neuron projection development glial cell proliferation postsynaptic density membrane kinase activity phosphorylation transferase activity NMDA selective glutamate receptor complex peptidyl-tyrosine phosphorylation enzyme binding lamellipodium cell junction cell differentiation regulation of cell adhesion negative regulation of ossification positive regulation of cell growth regulation of cell migration positive regulation of cell migration axon dendrite growth cone regulation of bone mineralization negative regulation of bone mineralization positive regulation of actin filament polymerization neuron projection development extrinsic component of cytoplasmic side of plasma membrane ubiquitin protein ligase binding positive regulation of cellular protein metabolic process regulation of inositol trisphosphate biosynthetic process tumor necrosis factor-mediated signaling pathway ionotropic glutamate receptor signaling pathway response to immobilization stress peptidyl-tyrosine autophosphorylation regulation of cell proliferation response to cocaine response to drug response to hydrogen peroxide activation of Janus kinase activity cell projection neuronal cell body negative regulation of apoptotic process stress fiber assembly dendritic spine negative regulation of potassium ion transport 3-phosphoinositide-dependent protein kinase binding positive regulation of JUN kinase activity negative regulation of neuron apoptotic process blood vessel endothelial cell migration positive regulation of phosphatidylinositol 3-kinase activity cell body macromolecular complex binding membrane raft regulation of nitric oxide biosynthetic process positive regulation of nitric oxide biosynthetic process bone resorption response to ethanol negative regulation of myeloid cell differentiation positive regulation of translation regulation of angiogenesis positive regulation of angiogenesis positive regulation of protein kinase activity positive regulation of JNK cascade vascular endothelial growth factor receptor signaling pathway focal adhesion assembly perinuclear region of cytoplasm positive regulation of peptidyl-tyrosine phosphorylation regulation of calcium-mediated signaling positive regulation of nitric-oxide synthase activity regulation of release of sequestered calcium ion into cytosol response to cAMP response to calcium ion positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation long term synaptic depression chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to fluid shear stress activation of GTPase activity apical dendrite postsynapse glutamatergic synapse regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process regulation of establishment of cell polarity regulation of actin cytoskeleton reorganization regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of reactive oxygen species metabolic process positive regulation of excitatory postsynaptic potential positive regulation of B cell chemotaxis positive regulation of DNA biosynthetic process uc011znr.1 uc011znr.2 uc011znr.3 
ENSMUST00000022623.13 Trim35 ENSMUST00000022623.13 tripartite motif-containing 35 (from RefSeq NM_029979.3) A0A0R4J031 A0A0R4J031_MOUSE ENSMUST00000022623.1 ENSMUST00000022623.10 ENSMUST00000022623.11 ENSMUST00000022623.12 ENSMUST00000022623.2 ENSMUST00000022623.3 ENSMUST00000022623.4 ENSMUST00000022623.5 ENSMUST00000022623.6 ENSMUST00000022623.7 ENSMUST00000022623.8 ENSMUST00000022623.9 NM_029979 Trim35 uc007ukd.1 uc007ukd.2 uc007ukd.3 zinc ion binding positive regulation of apoptotic process innate immune response negative regulation of mitotic cell cycle metal ion binding negative regulation of viral release from host cell uc007ukd.1 uc007ukd.2 uc007ukd.3 
ENSMUST00000022629.9 Dpysl2 ENSMUST00000022629.9 dihydropyrimidinase-like 2, transcript variant 2 (from RefSeq NM_009955.3) Crmp2 DPYL2_MOUSE ENSMUST00000022629.1 ENSMUST00000022629.2 ENSMUST00000022629.3 ENSMUST00000022629.4 ENSMUST00000022629.5 ENSMUST00000022629.6 ENSMUST00000022629.7 ENSMUST00000022629.8 NM_009955 O08553 Q6P5D0 Ulip2 uc007uko.1 uc007uko.2 uc007uko.3 Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1. Cytoplasm, cytosol Cytoplasm, cytoskeleton Membrane Note=Tightly but non-covalently associated with membranes. Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B (By similarity). Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure. response to amphetamine protein binding cytoplasm mitochondrion cytosol cytoskeleton plasma membrane endocytosis cytoskeleton organization multicellular organism development nervous system development axon guidance brain development microtubule binding regulation of neuron projection development positive regulation of glutamate secretion membrane hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides protein kinase binding spinal cord development olfactory bulb development cell differentiation axon dendrite growth cone regulation of axon extension macromolecular complex response to cocaine response to drug identical protein binding neuron projection neuronal cell body terminal bouton myelin sheath regulation of neuron differentiation synaptic vesicle transport presynapse microtubule dihydropyrimidinase activity pyrimidine nucleobase catabolic process uc007uko.1 uc007uko.2 uc007uko.3 
ENSMUST00000022634.9 Bnip3l ENSMUST00000022634.9 BCL2/adenovirus E1B interacting protein 3-like, transcript variant 1 (from RefSeq NM_009761.4) BNI3L_MOUSE ENSMUST00000022634.1 ENSMUST00000022634.2 ENSMUST00000022634.3 ENSMUST00000022634.4 ENSMUST00000022634.5 ENSMUST00000022634.6 ENSMUST00000022634.7 ENSMUST00000022634.8 NM_009761 Nix Q545J6 Q9Z2F7 uc007uks.1 uc007uks.2 uc007uks.3 uc007uks.4 Induces apoptosis. Interacts with viral and cellular anti- apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May function as a tumor suppressor (By similarity). Self-associates. Interacts with BNIP3 and STEAP3. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains) (By similarity). Q9Z2F7; Q69ZI1: Sh3rf1; NbExp=4; IntAct=EBI-1774669, EBI-957380; Q9Z2F7; O95166: GABARAP; Xeno; NbExp=2; IntAct=EBI-1774669, EBI-712001; Q9Z2F7; Q9H0R8: GABARAPL1; Xeno; NbExp=4; IntAct=EBI-1774669, EBI-746969; Q9Z2F7; P60520: GABARAPL2; Xeno; NbExp=2; IntAct=EBI-1774669, EBI-720116; Q9Z2F7; Q9H492: MAP1LC3A; Xeno; NbExp=7; IntAct=EBI-1774669, EBI-720768; Q9Z2F7; Q9GZQ8: MAP1LC3B; Xeno; NbExp=5; IntAct=EBI-1774669, EBI-373144; Nucleus envelope Endoplasmic reticulum Mitochondrion outer membrane Membrane ; Single-pass membrane protein Note=Colocalizes with SPATA18 at the mitochondrion outer membrane. Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin. Belongs to the NIP3 family. protein binding lamin binding nucleus nuclear envelope mitochondrion mitochondrial envelope mitochondrial outer membrane endoplasmic reticulum cytosol apoptotic process negative regulation of mitochondrial membrane potential membrane integral component of membrane positive regulation of macroautophagy nuclear speck mitochondrial protein catabolic process positive regulation of mitochondrial membrane permeability identical protein binding protein homodimerization activity positive regulation of apoptotic process negative regulation of apoptotic process protein heterodimerization activity defense response to virus negative regulation of cell death cellular response to hypoxia mitochondrial outer membrane permeabilization regulation of mitophagy regulation of protein targeting to mitochondrion uc007uks.1 uc007uks.2 uc007uks.3 uc007uks.4 
ENSMUST00000022638.6 Nefm ENSMUST00000022638.6 neurofilament, medium polypeptide (from RefSeq NM_008691.2) A0A0R4J036 A0A0R4J036_MOUSE ENSMUST00000022638.1 ENSMUST00000022638.2 ENSMUST00000022638.3 ENSMUST00000022638.4 ENSMUST00000022638.5 NM_008691 Nefm uc007ulo.1 uc007ulo.2 uc007ulo.3 Belongs to the intermediate filament family. structural molecule activity intermediate filament neurofilament neurofilament bundle assembly uc007ulo.1 uc007ulo.2 uc007ulo.3 
ENSMUST00000022639.8 Nefl ENSMUST00000022639.8 neurofilament, light polypeptide (from RefSeq NM_010910.2) ENSMUST00000022639.1 ENSMUST00000022639.2 ENSMUST00000022639.3 ENSMUST00000022639.4 ENSMUST00000022639.5 ENSMUST00000022639.6 ENSMUST00000022639.7 NFL_MOUSE NM_010910 Nf68 Nfl P08551 Q8K0Z0 uc007uln.1 uc007uln.2 uc007uln.3 uc007uln.4 Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (PubMed:22723690). Forms homodimers (in vitro) (By similarity). Forms heterodimers with NEFH or NEFM; which can further hetero-oligomerize (in vitro) (By similarity). Forms heterodimers with INA (in vitro) (By similarity). Interacts with ARHGEF28. Interacts with TRIM2. P08551; Q9ESN6: Trim2; NbExp=2; IntAct=EBI-445199, EBI-8315064; Cell projection, axon Cytoplasm, cytoskeleton Expressed in the sciatic nerve (at protein level). The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions. O-glycosylated. Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization. Ubiquitinated in the presence of TRIM2 and UBE2D1. Reduced levels of Nefm, Nefh and Prph in the sciatic nerve and reduced numbers of neurofilaments in sciatic axons. NF-L is the most abundant of the three neurofilament proteins and, like the other nonepithelial intermediate filament proteins, it can form homomeric 10-nm filaments. Belongs to the intermediate filament family. microtubule cytoskeleton organization structural constituent of cytoskeleton protein binding cytoplasm intermediate filament neurofilament protein C-terminus binding anterograde axonal transport retrograde axonal transport response to toxic substance response to organic substance peripheral nervous system axon regeneration axonal transport of mitochondrion protein domain specific binding spinal cord development hippocampus development cerebral cortex development axon growth cone protein binding, bridging regulation of axon diameter neuromuscular junction neurofilament bundle assembly locomotion identical protein binding neuron projection myelin sheath phospholipase binding response to peptide hormone negative regulation of neuron apoptotic process intermediate filament polymerization or depolymerization intermediate filament organization intermediate filament bundle assembly protein heterodimerization activity neuron projection morphogenesis positive regulation of axonogenesis neuromuscular process controlling balance protein polymerization response to corticosterone neurofilament cytoskeleton organization synapse maturation axon development cholinergic synapse response to sodium arsenite response to acrylamide axon cytoplasm uc007uln.1 uc007uln.2 uc007uln.3 uc007uln.4 
ENSMUST00000022640.8 Adam7 ENSMUST00000022640.8 a disintegrin and metallopeptidase domain 7 (from RefSeq NM_007402.2) ADAM7_MOUSE Adam7 ENSMUST00000022640.1 ENSMUST00000022640.2 ENSMUST00000022640.3 ENSMUST00000022640.4 ENSMUST00000022640.5 ENSMUST00000022640.6 ENSMUST00000022640.7 F8VQC6 NM_007402 O35227 uc007ulr.1 uc007ulr.2 uc007ulr.3 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is specifically expressed in epididymis where the encoded protein is transferred to the sperm surface during epididymal transit. This gene is located adjacent to a related gene from the ADAM family of proteins on chromosome 14. [provided by RefSeq, Oct 2015]. ##Evidence-Data-START## Transcript exon combination :: AK136692.1, AF013107.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Required for normal male fertility via maintenance of epithelial cell morphology in the caput epididymis and subsequently correct epididymis lumen structure required for sperm development (PubMed:26246218). Plays a role in sperm motility, flagella morphology and tyrosine phosphorylation during sperm capacitance (PubMed:26246218). Plays a role in normal expression levels of HSPA5, ITM2B and ADAM2 in sperm both prior to and post-capacitation (PubMed:26246218). This is a non catalytic metalloprotease-like protein (Probable). Interacts with ITM2B in sperm; the interaction increases following capacitation (PubMed:20945367). Interacts with HSPA5 and CANX (PubMed:20945367). Membrane ; Single- pass type I membrane protein Expressed in both the head and tails of sperm (at protein level) (PubMed:26246218, PubMed:20945367). Expressed in the epididymis (at protein level) (PubMed:26246218). Abundantly expressed in the apical region of the proximal caput epididymal epithelium, with decreasing expression in the mid and distal caput epididymal epithelium (PubMed:9322939). Induced by testis factors and androgens including testosterone. As a result of decreased egg fertilization male knockout mice produce a 15% reduced litter size whereas female knockout mice are unaffected (PubMed:26246218). No difference in male gross organ morphology (PubMed:26246218). Reduced epithelial cell heights in the caput regions of the epididymis, resulting in increased circumferences of the epididymal lumina (PubMed:26246218). Infrequent histological abnormalities can be found in the caput epididymis, such as sperm granulomas and mineralization-like features (PubMed:26246218). Increased frequency of intraepithelial vacuoles and hyperplasia found in the cauda epididymis (PubMed:26246218). Sperm obtained from the uterus of mated females show morphologically abnormal flagella with repeated bending and zigzag patterns (PubMed:26246218). Sperm incubated in vitro show reduced motility and abnormal flagella, additionally they show a reduction in overall levels of protein phosphotyrosine levels independent of capacitation state, resulting in an overall reduction in fertilization rate of 60% (PubMed:26246218). Decrease in protein levels of HSPA5 and ITM2B in both uncapacitated and capacitated sperm, and reduction in the levels of ADAM2 in capacitated sperm (PubMed:26246218). endopeptidase activity metalloendopeptidase activity plasma membrane proteolysis metallopeptidase activity membrane integral component of membrane apical part of cell uc007ulr.1 uc007ulr.2 uc007ulr.3 
ENSMUST00000022641.9 Adamdec1 ENSMUST00000022641.9 ADAM-like, decysin 1 (from RefSeq NM_021475.3) ADEC1_MOUSE ENSMUST00000022641.1 ENSMUST00000022641.2 ENSMUST00000022641.3 ENSMUST00000022641.4 ENSMUST00000022641.5 ENSMUST00000022641.6 ENSMUST00000022641.7 ENSMUST00000022641.8 NM_021475 Q9R0X2 uc007uls.1 uc007uls.2 uc007uls.3 May play an important role in the control of the immune response and during pregnancy. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted. Expressed highly in uterus during pregnancy. From the prepubertal period to day 5.5 of pregnancy is weakly expressed. From day 5.5 of pregnancy, an increase of expression is observed. At day 12.5 expression is higher. Induced by immunization in mature dendritic cells (DC), in marginal zone (MZ) metallophils, in follicular DC (FDC) and tingible body macrophages of germinal center. Down-regulated by steroid hormones and PRL. metalloendopeptidase activity cellular_component extracellular region proteolysis peptidase activity metallopeptidase activity hydrolase activity metal ion binding uc007uls.1 uc007uls.2 uc007uls.3 
ENSMUST00000022646.9 Nkx3-1 ENSMUST00000022646.9 NK3 homeobox 1 (from RefSeq NM_010921.3) ENSMUST00000022646.1 ENSMUST00000022646.2 ENSMUST00000022646.3 ENSMUST00000022646.4 ENSMUST00000022646.5 ENSMUST00000022646.6 ENSMUST00000022646.7 ENSMUST00000022646.8 NM_010921 Nkx3-1 Q3UVH8 Q3UVH8_MOUSE uc007umd.1 uc007umd.2 uc007umd.3 Nucleus transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding positive regulation of protein phosphorylation DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding nucleus regulation of transcription, DNA-templated activation of cysteine-type endopeptidase activity involved in apoptotic process transcription factor binding positive regulation of cell proliferation negative regulation of cell proliferation cysteine-type endopeptidase activator activity involved in apoptotic process positive regulation of gene expression negative regulation of gene expression positive regulation of cell death positive regulation of phosphatidylinositol 3-kinase signaling estrogen receptor activity estrogen receptor binding androgen receptor signaling pathway regulation of protein localization cellular response to drug histone deacetylase binding positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase B signaling sequence-specific DNA binding protein self-association transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of cell division cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to steroid hormone stimulus cellular response to hypoxia mitotic cell cycle arrest negative regulation of estrogen receptor binding positive regulation of androgen secretion positive regulation of response to DNA damage stimulus positive regulation of apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway uc007umd.1 uc007umd.2 uc007umd.3 
ENSMUST00000022650.9 Pibf1 ENSMUST00000022650.9 progesterone immunomodulatory binding factor 1, transcript variant 4 (from RefSeq NR_188874.1) E9Q6K3 E9Q6K3_MOUSE ENSMUST00000022650.1 ENSMUST00000022650.2 ENSMUST00000022650.3 ENSMUST00000022650.4 ENSMUST00000022650.5 ENSMUST00000022650.6 ENSMUST00000022650.7 ENSMUST00000022650.8 NR_188874 Pibf1 uc007uvc.1 uc007uvc.2 uc007uvc.3 uc007uvc.4 interleukin-4 receptor binding extracellular space nucleus centrosome microtubule organizing center mitotic metaphase plate congression negative regulation of prostaglandin biosynthetic process negative regulation of interleukin-12 production positive regulation of interleukin-10 production negative regulation of natural killer cell activation centriolar satellite positive regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein activation of Janus kinase activity cilium assembly protein localization to centrosome mitotic spindle assembly non-motile cilium assembly uc007uvc.1 uc007uvc.2 uc007uvc.3 uc007uvc.4 
ENSMUST00000022656.8 Bora ENSMUST00000022656.8 bora, aurora kinase A activator, transcript variant 1 (from RefSeq NM_175265.6) BORA_MOUSE ENSMUST00000022656.1 ENSMUST00000022656.2 ENSMUST00000022656.3 ENSMUST00000022656.4 ENSMUST00000022656.5 ENSMUST00000022656.6 ENSMUST00000022656.7 NM_175265 Q3TJH7 Q3UWZ8 Q80WQ5 Q8BS90 Q8C8E9 uc007uuv.1 uc007uuv.2 uc007uuv.3 Required for the activation of AURKA at the onset of mitosis. Interacts with AURKA. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BS90-1; Sequence=Displayed; Name=2; IsoId=Q8BS90-2; Sequence=VSP_022496, VSP_022497; Phosphorylated by AURKA. Belongs to the BORA family. Sequence=BAC33015.1; Type=Frameshift; Evidence=; nucleus cytoplasm cell cycle regulation of mitotic nuclear division protein kinase binding activation of protein kinase activity regulation of protein localization cell division regulation of mitotic spindle organization meiotic spindle uc007uuv.1 uc007uuv.2 uc007uuv.3 
ENSMUST00000022660.14 Loxl2 ENSMUST00000022660.14 Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (By similarity). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (By similarity). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (By similarity). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (By similarity). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (PubMed:25959397). Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 (By similarity). During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction (By similarity). When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (By similarity). Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (By similarity). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (PubMed:21071451). (from UniProt P58022) AK034957 ENSMUST00000022660.1 ENSMUST00000022660.10 ENSMUST00000022660.11 ENSMUST00000022660.12 ENSMUST00000022660.13 ENSMUST00000022660.2 ENSMUST00000022660.3 ENSMUST00000022660.4 ENSMUST00000022660.5 ENSMUST00000022660.6 ENSMUST00000022660.7 ENSMUST00000022660.8 ENSMUST00000022660.9 LOXL2_MOUSE P58022 Q8BRE6 Q8BS86 Q8C4K0 Q9JJ39 uc007umn.1 uc007umn.2 uc007umn.3 uc007umn.4 uc007umn.5 Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (By similarity). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (By similarity). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (By similarity). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (By similarity). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (PubMed:25959397). Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 (By similarity). During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction (By similarity). When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (By similarity). Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (By similarity). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (PubMed:21071451). Reaction=H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl- [protein] + H2O2 + NH4(+); Xref=Rhea:RHEA:24544, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:12448, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:131803; EC=1.4.3.13; Evidence=; Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Name=lysine tyrosylquinone residue; Xref=ChEBI:CHEBI:20489; Evidence=; Note=Contains 1 lysine tyrosylquinone. Specifically inhibited by a mouse monoclonal antibody AB0023, inhibition occurs in a non-competitive manner. Component of some chromatin repressor complex. Interacts with SNAI1. Interacts with TAF10. Interacts with HSPA5. Interacts with EFEMP2 (By similarity). Secreted, extracellular space, extracellular matrix, basement membrane Nucleus Chromosome Endoplasmic reticulum Note=Associated with chromatin. It is unclear how LOXL2 is nuclear as it contains a signal sequence and has been shown to be secreted. However, a number of reports confirm its intracellular location and its key role in transcription regulation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P58022-1; Sequence=Displayed; Name=2; IsoId=P58022-2; Sequence=VSP_016231, VSP_016232; Ubiquitous. Highest expression in skin, lung and thymus. Present in chondrocytes: mainly expressed by chondrocytes in healing fractures and in epiphyseal growth plates (at protein level). Strongly induced in hypoxia. The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. N-glycosylated. N-glycosylation on Asn-458 and Asn-646 may be essential for proper folding and secretion; may be composed of a fucosylated carbohydrates attached to a trimannose N-linked glycan core. Belongs to the lysyl oxidase family. negative regulation of transcription from RNA polymerase II promoter chromatin response to hypoxia epithelial to mesenchymal transition endothelial cell proliferation sprouting angiogenesis protein-lysine 6-oxidase activity scavenger receptor activity copper ion binding calcium ion binding extracellular region basement membrane extracellular space nucleus nucleoplasm chromosome endoplasmic reticulum chromatin organization cellular protein modification process endocytosis positive regulation of epithelial to mesenchymal transition membrane oxidoreductase activity oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor peptidyl-lysine oxidation collagen fibril organization positive regulation of chondrocyte differentiation endothelial cell migration negative regulation of transcription, DNA-templated response to copper ion metal ion binding oxidation-reduction process oligosaccharide binding heterochromatin organization negative regulation of stem cell population maintenance uc007umn.1 uc007umn.2 uc007umn.3 uc007umn.4 uc007umn.5 
ENSMUST00000022663.7 Tnfrsf10b ENSMUST00000022663.7 tumor necrosis factor receptor superfamily, member 10b (from RefSeq NM_020275.4) Dr5 ENSMUST00000022663.1 ENSMUST00000022663.2 ENSMUST00000022663.3 ENSMUST00000022663.4 ENSMUST00000022663.5 ENSMUST00000022663.6 Killer NM_020275 Q6GSD9 Q9JJL5 Q9JJL6 Q9QZM4 TR10B_MOUSE uc007umv.1 uc007umv.2 uc007umv.3 Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. Monomer. Can interact with TRADD and RIPK1. Three TNFRSF10B molecules interact with the TNFSF10 homotrimer. In the absence of stimulation, interacts with BIRC2, DDX3X and GSK3B. The interaction with BIRC2 and DDX3X is further enhanced upon receptor stimulation and accompanied by DDX3X and BIRC2 cleavage (By similarity). Membrane; Single-pass type I membrane protein. Highly expressed in heart, lung and kidney. TNFRSF10B is regulated by the tumor suppressor p53. (Microbial infection) Glycosylated at Arg-293 by S.typhimurium protein Ssek3. protease binding plasma membrane apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction transcription factor binding extrinsic apoptotic signaling pathway via death domain receptors cysteine-type endopeptidase activator activity involved in apoptotic process cell surface membrane integral component of membrane response to endoplasmic reticulum stress TRAIL-activated apoptotic signaling pathway regulation of apoptotic process positive regulation of apoptotic process TRAIL binding intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress extrinsic apoptotic signaling pathway uc007umv.1 uc007umv.2 uc007umv.3 
ENSMUST00000022665.4 Rhobtb2 ENSMUST00000022665.4 Rho-related BTB domain containing 2 (from RefSeq NM_153514.5) Dbc2 ENSMUST00000022665.1 ENSMUST00000022665.2 ENSMUST00000022665.3 NM_153514 Q8BYU3 Q8K1A8 Q91V93 RHBT2_MOUSE uc011znx.1 uc011znx.2 uc011znx.3 Interacts with HSP90AA1 and HSP90AB1. Interacts with CUL3. Expressed in most tissues, with highest expression in brain. Belongs to the small GTPase superfamily. Rho family. nucleotide binding GTPase activity protein binding GTP binding cytoplasm cell cortex actin filament organization small GTPase mediated signal transduction Rho protein signal transduction regulation of cell shape protein kinase binding regulation of cell migration establishment or maintenance of actin cytoskeleton polarity cell division site regulation of actin cytoskeleton organization intracellular membrane-bounded organelle actin filament bundle assembly plasma membrane uc011znx.1 uc011znx.2 uc011znx.3 
ENSMUST00000022666.9 Klhl1 ENSMUST00000022666.9 kelch-like 1 (from RefSeq NM_053105.3) ENSMUST00000022666.1 ENSMUST00000022666.2 ENSMUST00000022666.3 ENSMUST00000022666.4 ENSMUST00000022666.5 ENSMUST00000022666.6 ENSMUST00000022666.7 ENSMUST00000022666.8 KLHL1_MOUSE NM_053105 Q505E9 Q9JI74 uc007uuq.1 uc007uuq.2 uc007uuq.3 May play a role in organizing the actin cytoskeleton of the brain cells. Cytoplasm, cytoskeleton. Highly expressed in brain. actin binding cytoplasm cytoskeleton locomotory behavior adult walking behavior dendrite development cerebellar Purkinje cell layer development dendrite neuronal cell body uc007uuq.1 uc007uuq.2 uc007uuq.3 
ENSMUST00000022678.5 Pebp4 ENSMUST00000022678.5 phosphatidylethanolamine binding protein 4, transcript variant 1 (from RefSeq NM_028560.4) ENSMUST00000022678.1 ENSMUST00000022678.2 ENSMUST00000022678.3 ENSMUST00000022678.4 G3X8V3 NM_028560 PEBP4_MOUSE Q9D9G2 uc007una.1 uc007una.2 uc007una.3 uc007una.4 Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway. Secreted Belongs to the phosphatidylethanolamine-binding protein family. lysosome biological_process uc007una.1 uc007una.2 uc007una.3 uc007una.4 
ENSMUST00000022680.9 Bin3 ENSMUST00000022680.9 bridging integrator 3, transcript variant 1 (from RefSeq NM_021328.4) BIN3_MOUSE ENSMUST00000022680.1 ENSMUST00000022680.2 ENSMUST00000022680.3 ENSMUST00000022680.4 ENSMUST00000022680.5 ENSMUST00000022680.6 ENSMUST00000022680.7 ENSMUST00000022680.8 NM_021328 Q9JI08 uc007une.1 uc007une.2 uc007une.3 Involved in cytokinesis and septation where it has a role in the localization of F-actin. Cytoplasm, cytoskeleton barrier septum assembly cytoplasm cytoskeleton endocytosis cell cycle cytoskeletal protein binding protein localization unidimensional cell growth regulation of lamellipodium assembly myoblast migration involved in skeletal muscle regeneration actin cortical patch skeletal muscle tissue regeneration skeletal muscle fiber development cell division actin cortical patch localization plasma membrane tubulation actin filament lipid binding uc007une.1 uc007une.2 uc007une.3 
ENSMUST00000022681.11 Pdlim2 ENSMUST00000022681.11 PDZ and LIM domain 2, transcript variant 1 (from RefSeq NM_145978.2) ENSMUST00000022681.1 ENSMUST00000022681.10 ENSMUST00000022681.2 ENSMUST00000022681.3 ENSMUST00000022681.4 ENSMUST00000022681.5 ENSMUST00000022681.6 ENSMUST00000022681.7 ENSMUST00000022681.8 ENSMUST00000022681.9 NM_145978 PDLI2_MOUSE Q8R1G6 uc007uni.1 uc007uni.2 uc007uni.3 Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity). Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9 (By similarity). Interacts (via LIM zinc-binding domain) with MKRN2 (PubMed:28378844). Cytoplasm. Cytoplasm, cytoskeleton. Note=Localizes at the cytoskeleton. Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN) (By similarity). Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced.; Name=1; IsoId=Q8R1G6-1; Sequence=Displayed; Highly expressed in lung. Expressed at intermediate level in kidney, testis and spleen. Weakly expressed in heart and brain. Regulated by IGF-1. stress fiber actin binding cytoplasm cytoskeleton cell-cell adherens junction heart development Z disc actin cytoskeleton organization cortical actin cytoskeleton filamin binding filamentous actin myosin heavy chain binding metal ion binding muscle alpha-actinin binding alpha-actinin binding muscle structure development uc007uni.1 uc007uni.2 uc007uni.3 
ENSMUST00000022682.6 Sorbs3 ENSMUST00000022682.6 sorbin and SH3 domain containing 3, transcript variant 1 (from RefSeq NM_011366.4) ENSMUST00000022682.1 ENSMUST00000022682.2 ENSMUST00000022682.3 ENSMUST00000022682.4 ENSMUST00000022682.5 NM_011366 Q62423 Q9R1Z8 Scam1 Sh3d4 VINEX_MOUSE uc007unl.1 uc007unl.2 uc007unl.3 Promotes up-regulation of actin stress fiber formation. Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2, INPPL1/SHIP2 and SRCIN1 (By similarity). Interacts with DLG5 through its third SH3 domain. Interacts with SOCS7 and MAPK1/ERK2. Interacts with FASLG (By similarity). Cell junction, focal adhesion. Cell junction. Cytoplasm, cytoskeleton. Note=Localized at focal adhesion sites, cell- cell junctions and cell-extracellular matrix junctions. Phosphorylated at Ser-594 by MAPK1/ERK2 during cell spreading. negative regulation of transcription from RNA polymerase II promoter nucleus cytoplasm cytoskeleton focal adhesion actin filament organization cell adhesion transcription factor binding vinculin binding cell junction cell-substrate adhesion positive regulation of MAPK cascade positive regulation of stress fiber assembly uc007unl.1 uc007unl.2 uc007unl.3 
ENSMUST00000022688.10 Slc39a14 ENSMUST00000022688.10 solute carrier family 39 (zinc transporter), member 14, transcript variant 1 (from RefSeq NM_001135151.1) A0A0R4J1V1 ENSMUST00000022688.1 ENSMUST00000022688.2 ENSMUST00000022688.3 ENSMUST00000022688.4 ENSMUST00000022688.5 ENSMUST00000022688.6 ENSMUST00000022688.7 ENSMUST00000022688.8 ENSMUST00000022688.9 Fad123 Kiaa0062 NM_001135151 Q75N73 Q80U85 Q8VDL0 S39AE_MOUSE Slc39a14 Zip14 uc007unu.1 uc007unu.2 uc007unu.3 Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:15863613, PubMed:16950869, PubMed:18270315, PubMed:19179618, PubMed:21653899, PubMed:28673968). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (PubMed:18270315). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:18270315). Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (PubMed:25428902). Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (PubMed:21445361). Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010). Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (PubMed:28673968). Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake (PubMed:31028174). Also involved in manganese extracellular uptake by cells of the blood-brain barrier (By similarity). May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (PubMed:28536273). Also functions in the extracellular uptake of free iron (PubMed:16950869, PubMed:19179618, PubMed:21653899, PubMed:23110240, PubMed:26028554). May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages (By similarity). Reaction=2 hydrogencarbonate(out) + Zn(2+)(out) = 2 hydrogencarbonate(in) + Zn(2+)(in); Xref=Rhea:RHEA:62252, ChEBI:CHEBI:17544, ChEBI:CHEBI:29105; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62253; Evidence= Reaction=2 hydrogencarbonate(out) + Mn(2+)(out) = 2 hydrogencarbonate(in) + Mn(2+)(in); Xref=Rhea:RHEA:62260, ChEBI:CHEBI:17544, ChEBI:CHEBI:29035; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62261; Evidence=; Reaction=Fe(2+)(out) + 2 hydrogencarbonate(out) = Fe(2+)(in) + 2 hydrogencarbonate(in); Xref=Rhea:RHEA:62368, ChEBI:CHEBI:17544, ChEBI:CHEBI:29033; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62369; Evidence=; Reaction=Cd(2+)(out) + 2 hydrogencarbonate(out) = Cd(2+)(in) + 2 hydrogencarbonate(in); Xref=Rhea:RHEA:62256, ChEBI:CHEBI:17544, ChEBI:CHEBI:48775; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62257; Evidence=; Inhibited by cyanide and therefore dependent of an energy source (PubMed:18270315). Inhibited by DIDS/4,4'- diisothiocyanatostilbene-2,2'-disulfonic acid, an inhibitor hydrogencarbonate-dependent transporters (PubMed:18270315). pH dependence: Optimum pH is 7.5. ; Temperature dependence: Optimum temperature is 37 degrees Celsius. ; [Isoform 1]: Kinetic parameters: KM=0.14 mM for Cd(2+) ; KM=4.4 mM for Mn(2+) ; KM=2.3 uM for Fe(2+) ; KM=1.9 uM for Zn(2+) ; Vmax=25 pmol/min/mg enzyme for the transport of Cd(2+) ; Vmax=330 pmol/min/mg enzyme for the transport of Mn(2+) ; pH dependence: Optimum pH is 7.5. Temperature dependence: Optimum temperature is 37 degrees Celsius. ; [Isoform 2]: Kinetic parameters: KM=1.1 mM for Cd(2+) ; KM=18.2 mM for Mn(2+) ; Vmax=113 pmol/min/mg enzyme for the transport of Cd(2+) ; Vmax=1140 pmol/min/mg enzyme for the transport of Mn(2+) ; pH dependence: Optimum pH is 7.5 (PubMed:18270315). Optimum temperature is 37 degrees Celsius (PubMed:18270315). ; Homotrimer. Cell membrane ulti-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Note=Localized at the basolateral membrane of enterocytes (PubMed:25428902, PubMed:28536273). Enriched at the plasma membrane upon glucose uptake (By similarity). Localized and functional at both apical and basolateral membranes of microvascular capillary endothelial cells that constitute the blood-brain barrier (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=ZIP14B ; IsoId=Q75N73-1; Sequence=Displayed; Name=2; Synonyms=ZIP14A ; IsoId=Q75N73-3; Sequence=VSP_060552; Widely expressed (PubMed:18270315). Highly and transiently expressed during the early stage of adipocyte differentiation. Strongly expressed in liver, preadipocyte, duodenum and jejunum, moderately in brain, heart, skeletal muscle, spleen, pancreas, kidney and white adipose cells. Expression is almost undetectable in lung, testis and brown adipose cells (PubMed:15794747, PubMed:15863613, PubMed:16950869, PubMed:17065364, PubMed:25428902). Expressed by chondrocytes and pituitary cells (PubMed:21445361). [Isoform 1]: More strongly expressed in brain. [Isoform 2]: More strongly expressed in liver, kidney and duodenum. In the KS483 cell model for osteoblast differentiation, expression levels peaks during the mineralization phase (days 18-21 of differentiation). Up-regulated during the lipopolysaccharide/LPS-induced inflammatory response (at protein level) (PubMed:16950869). Up- regulated by IL6 (PubMed:15863613, PubMed:16950869, PubMed:17065364). Up-regulated by interleukin-1/IL1 via nitric oxide (PubMed:19179618). Up-regulated upon endoplasmic reticulum stress induced by tunicamycin or high-fat diet (at protein level) (PubMed:28673968). Up-regulated into hepatocytes upon glucose uptake (at protein level) (PubMed:27703010). Up-regulated by iron in retina (at protein level) (PubMed:28057442). Ubiquitinated. Ubiquitination occurs upon iron depletion. The ubiquitinated form undergoes proteasomal degradation. N-glycosylated (PubMed:18270315, PubMed:21445361). N-glycosylation at Asn-100 is required for iron-regulated extraction of the transporter from membranes and subsequent proteasomal degradation (By similarity). Homozygous knockout mice exhibit growth retardation and dwarfism, visible even in neonates (PubMed:21445361). They exhibit moderate osteoporotic phenotypes associated with decreased bone volume and trabecular number, and increased trabecular separation (PubMed:21445361). The length of the long bones is also significantly reduced (PubMed:21445361). The decrease in bone mass is associated with increased bone resorption (PubMed:29632817). The metabolism of these mice is also affected and they constitute a model of metabolic endotoxemia with high body fat, hypoglycemia and hyperinsulinemia (PubMed:23110240, PubMed:27703010). The knockout of the gene also results in less effective blood manganese elimination and accumulation in the brain where it alters motor functions (PubMed:28536273). Knockout mice also display increased iron absorption and decreased lipopolysaccharide/LPS-induced IL-6 production (PubMed:23110240, PubMed:26028554). The permeability of the intestinal barrier is also compromised (PubMed:25428902). Conditional intestinal-specific knockout of the gene results in increased manganese levels in brain and liver while the liver-specific knockout reduces manganese levels only in liver (PubMed:31028174). Belongs to the ZIP transporter (TC 2.A.5) family. [Isoform 1]: Sequence=BAC65479.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; manganese ion transmembrane transporter activity zinc ion transmembrane transporter activity cytoplasm plasma membrane integral component of plasma membrane ion transport iron ion transport zinc II ion transport cellular zinc ion homeostasis ferrous iron transmembrane transporter activity membrane integral component of membrane metal ion transport lamellipodium iron ion transmembrane transport cell projection metal ion transmembrane transporter activity transmembrane transport manganese ion transmembrane transport zinc II ion transmembrane transport zinc II ion transmembrane import uc007unu.1 uc007unu.2 uc007unu.3 
ENSMUST00000022690.10 Fhip2b ENSMUST00000022690.10 FHF complex subunit HOOK interacting protein 2B (from RefSeq NM_194345.1) ENSMUST00000022690.1 ENSMUST00000022690.2 ENSMUST00000022690.3 ENSMUST00000022690.4 ENSMUST00000022690.5 ENSMUST00000022690.6 ENSMUST00000022690.7 ENSMUST00000022690.8 ENSMUST00000022690.9 FHI2B_MOUSE Fam160b2 Fhip2b NM_194345 Q6PED9 Q80YR2 Q8C1Y2 Rai16 uc007uol.1 uc007uol.2 uc007uol.3 uc007uol.4 Able to activate MAPK/ERK and TGFB signaling pathways (By similarity). May regulate the activity of genes involved in intestinal barrier function and immunoprotective inflammation (PubMed:31862898). May play a role in cell proliferation (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80YR2-1; Sequence=Displayed; Name=2; IsoId=Q80YR2-2; Sequence=VSP_024588, VSP_024589; Expressed in colon. Mutants are viable, fertile with no apparent defects. Mice are more susceptibility to colitis induced by dextran sodium sulfate (DSS) than wild type littermates (PubMed:31862898). They display significantly increased tumor burden compared with WT mice assessed in colitis-associated colorectal cancer model induced by azoxymethane (AOM)-DSS (PubMed:31862898). Belongs to the FHIP family. Sequence=AAH50861.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC41057.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc007uol.1 uc007uol.2 uc007uol.3 uc007uol.4 
ENSMUST00000022691.14 Hr ENSMUST00000022691.14 lysine demethylase and nuclear receptor corepressor, transcript variant 2 (from RefSeq NM_021877.3) ENSMUST00000022691.1 ENSMUST00000022691.10 ENSMUST00000022691.11 ENSMUST00000022691.12 ENSMUST00000022691.13 ENSMUST00000022691.2 ENSMUST00000022691.3 ENSMUST00000022691.4 ENSMUST00000022691.5 ENSMUST00000022691.6 ENSMUST00000022691.7 ENSMUST00000022691.8 ENSMUST00000022691.9 HAIR_MOUSE NM_021877 Q61645 Q80Y47 uc007uoj.1 uc007uoj.2 uc007uoj.3 This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory ORF that exists upstream of the primary ORF. Mutations in this upstream ORF, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss in human. [provided by RefSeq, Oct 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC049182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164132, SAMN01164136 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 19122663 ##RefSeq-Attributes-END## Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. Reaction=2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60188, Rhea:RHEA-COMP:15541, Rhea:RHEA- COMP:15546, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61976; EC=1.14.11.65; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Nucleus. Expressed predominantly in brain, hair follicles and interfollicular epidermis. No expression in dermis. Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors (By similarity). The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. Note=Defects in Hr are the cause of a number of pleiotropic effects including structural abnormalities of epithelial cells in the hair follicles, hair loss towards the end of the first hair growth cycle, and the failure of subsequent hair growth cycles. Older mice carrying a hr mutation have been reported to possess altered ratios of T-cell-dependent B-cell responses. Mice homozygous for hr mutation are uniquely sensitive to UV and chemically induced skin tumors. histone deacetylase complex chromatin transcription regulatory region sequence-specific DNA binding DNA binding transcription corepressor activity protein binding nucleus nucleoplasm oxidoreductase activity nuclear body chromatin DNA binding histone demethylase activity (H3-K9 specific) histone H3-K9 demethylation vitamin D receptor binding histone deacetylase binding negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated metal ion binding thyroid hormone receptor binding protein heterooligomerization oxidation-reduction process uc007uoj.1 uc007uoj.2 uc007uoj.3 
ENSMUST00000022692.5 Sftpc ENSMUST00000022692.5 surfactant associated protein C (from RefSeq NM_011359.2) ENSMUST00000022692.1 ENSMUST00000022692.2 ENSMUST00000022692.3 ENSMUST00000022692.4 NM_011359 Q6P8P8 Q6P8P8_MOUSE Sftpc uc007uoe.1 uc007uoe.2 uc007uoe.3 uc007uoe.4 uc007uoe.5 Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. Secreted, extracellular space, surface film extracellular region respiratory gaseous exchange membrane integral component of membrane identical protein binding uc007uoe.1 uc007uoe.2 uc007uoe.3 uc007uoe.4 uc007uoe.5 
ENSMUST00000022693.9 Bmp1 ENSMUST00000022693.9 bone morphogenetic protein 1, transcript variant 1 (from RefSeq NM_009755.4) BMP1_MOUSE ENSMUST00000022693.1 ENSMUST00000022693.2 ENSMUST00000022693.3 ENSMUST00000022693.4 ENSMUST00000022693.5 ENSMUST00000022693.6 ENSMUST00000022693.7 ENSMUST00000022693.8 NM_009755 P98063 Q6NZM2 uc007uoc.1 uc007uoc.2 uc007uoc.3 uc007uoc.4 This gene encodes a metalloproteinase that plays an essential role in the formation of the extracellular matrix and is also able to induce ectopic bone formation. Unlike other bone morphogenetic proteins, the protein encoded by this gene is not closely related to transforming growth factor-beta. This protein plays in role several developmental processes. In humans, mutations in this gene are associated with osteogenesis imperfecta and with increased bone mineral density and multiple recurrent fractures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066062.1, AK004995.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:24419319, PubMed:8951074, PubMed:28068493). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers (PubMed:20181949). Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (By similarity). Reaction=Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III.; EC=3.4.24.19; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. Activity is increased by the procollagen C- endopeptidase enhancer protein. Interacts with POSTN, the interaction promotes deposition on the extracellular matrix. Golgi apparatus, trans-Golgi network Secreted, extracellular space, extracellular matrix Secreted Note=Co-localizes with POSTN in the Golgi. At high levels in embryonic maternal deciduum and floor plate region of the neural tube. Less in developing membranous and endochondral bone, submucosa of intestine, dermis of skin and the mesenchyme of spleen and lung. Deletion mice are perinatally lethal, with the most obvious gross abnormality being failure of ventral body wall closure, and persistent herniation of the gut. This phenotype likely reflects the defective and weakened nature of extracellular matrix (ECM) in these embryos (PubMed:8951074). Double knockout mice (BMP1 and TLL1) display progressive defects in teeth and bone development (PubMed:28068493, PubMed:24419319). Sequence=AAA37306.1; Type=Frameshift; Evidence=; ossification metalloendopeptidase activity cytokine activity calcium ion binding protein binding extracellular region extracellular space Golgi apparatus proteolysis signal transduction multicellular organism development growth factor activity peptidase activity metallopeptidase activity zinc ion binding hydrolase activity cell differentiation vesicle identical protein binding metal ion binding cartilage development positive regulation of cartilage development uc007uoc.1 uc007uoc.2 uc007uoc.3 uc007uoc.4 
ENSMUST00000022694.17 Dmtn ENSMUST00000022694.17 dematin actin binding protein, transcript variant 9 (from RefSeq NM_001360026.1) DEMA_MOUSE ENSMUST00000022694.1 ENSMUST00000022694.10 ENSMUST00000022694.11 ENSMUST00000022694.12 ENSMUST00000022694.13 ENSMUST00000022694.14 ENSMUST00000022694.15 ENSMUST00000022694.16 ENSMUST00000022694.2 ENSMUST00000022694.3 ENSMUST00000022694.4 ENSMUST00000022694.5 ENSMUST00000022694.6 ENSMUST00000022694.7 ENSMUST00000022694.8 ENSMUST00000022694.9 Epb4.9 Epb49 F8WIF9 NM_001360026 Q3TYC5 Q8JZV5 Q9WV69 Q9WVM2 uc057kta.1 uc057kta.2 uc057kta.3 Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. Monomeric (isoform 2); under reducing conditions. Self- associates. Exists under oxidizing condition as a trimer of two isoforms 2 and isoform 1 linked by disulfide bonds (Probable). Found in a complex with DMTN, F-actin and spectrin. Found in a complex with ADD2, DMTN and SLC2A1. Interacts with F-actin, ITPKB and spectrin. Isoform 2 interacts with SLC2A1 (via C-terminus cytoplasmic region) (By similarity). Interacts with RASGRF2. Cytoplasm Cytoplasm, cytosol Cytoplasm, perinuclear region Cytoplasm, cytoskeleton Cell membrane Membrane Endomembrane system Cell projection Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9WV69-1; Sequence=Displayed; Name=2; IsoId=Q9WV69-2; Sequence=VSP_047492; Name=3; IsoId=Q9WV69-3; Sequence=VSP_047491; Name=4; IsoId=Q9WV69-4; Sequence=VSP_047491, VSP_047492; Expressed in platelets. Isoform 1 and isoform 2 are expressed in mature erythrocytes (at protein level). Both the N-terminal core domain and the C-terminal headpiece domain are sufficient for binding to F-actin and necessary for actin bundling activity. Phosphorylated. Phosphorylation at Ser-403 by PKA causes the C- terminal headpiece domain to associate with the N-terminal core domain, and leads to the inhibition of its actin bundling activity (By similarity). Mice are viable and born at the expected Mendelian ratio. Adult mice show compensated anemia and display mild microcytosis and spherocytosis. The erythrocyte plasma membrane association with the spectrin-actin skeleton is fragile and mechanically unstable. Belongs to the villin/gelsolin family. actin binding receptor binding cytoplasm cytosol cytoskeleton actin filament plasma membrane cytoskeleton organization regulation of cell shape regulation of lamellipodium assembly positive regulation of fibroblast migration negative regulation of peptidyl-threonine phosphorylation negative regulation of cell-substrate adhesion endomembrane system postsynaptic density spectrin-associated cytoskeleton actin cytoskeleton membrane lamellipodium assembly actin cytoskeleton organization positive regulation of blood coagulation spectrin binding cortical cytoskeleton platelet dense tubular network membrane cell projection membrane cytoplasmic vesicle regulation of actin cytoskeleton organization negative regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source calcium-mediated signaling using extracellular calcium source cell projection protein self-association perinuclear region of cytoplasm erythrocyte development negative regulation of peptidyl-tyrosine phosphorylation actin filament binding actin filament bundle assembly regulation of filopodium assembly actin filament capping negative regulation of focal adhesion assembly macromolecular complex assembly protein secretion by platelet cellular response to calcium ion cellular response to cAMP positive regulation of wound healing negative regulation of protein targeting to membrane actin filament reorganization negative regulation of substrate adhesion-dependent cell spreading positive regulation of substrate adhesion-dependent cell spreading positive regulation of platelet aggregation positive regulation of integrin-mediated signaling pathway uc057kta.1 uc057kta.2 uc057kta.3 
ENSMUST00000022696.8 Xpo7 ENSMUST00000022696.8 exportin 7, transcript variant 2 (from RefSeq NM_023045.3) ENSMUST00000022696.1 ENSMUST00000022696.2 ENSMUST00000022696.3 ENSMUST00000022696.4 ENSMUST00000022696.5 ENSMUST00000022696.6 ENSMUST00000022696.7 Kiaa0745 NM_023045 Q3TP94 Q80TS9 Q8BSK5 Q8C9M7 Q8CB42 Q8CBL8 Q8CEF5 Q9EPK7 Ranbp16 XPO7_MOUSE uc033gsa.1 uc033gsa.2 uc033gsa.3 Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Binds to nucleoporins. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ARHGAP1 and SFN. Interacts with Ran and cargo proteins in a GTP-dependent manner (By similarity). Cytoplasm Nucleus Note=Shuttles between the nucleus and the cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EPK7-1; Sequence=Displayed; Name=2; IsoId=Q9EPK7-2; Sequence=VSP_018600; Highly expressed in testis and spleen, moderate in kidney and liver and low in heart, brain, lung and skeletal muscle. Belongs to the exportin family. nuclear export signal receptor activity protein binding nucleus nuclear pore cytoplasm protein export from nucleus intracellular protein transport nucleocytoplasmic transport Ran GTPase binding protein transport mRNA transport nuclear transport uc033gsa.1 uc033gsa.2 uc033gsa.3 
ENSMUST00000022697.7 Fgf17 ENSMUST00000022697.7 fibroblast growth factor 17, transcript variant 1 (from RefSeq NM_008004.6) ENSMUST00000022697.1 ENSMUST00000022697.2 ENSMUST00000022697.3 ENSMUST00000022697.4 ENSMUST00000022697.5 ENSMUST00000022697.6 Fgf17 NM_008004 Q0VF19 Q0VF19_MOUSE uc007uos.1 uc007uos.2 uc007uos.3 Belongs to the heparin-binding growth factors family. fibroblast growth factor receptor binding type 1 fibroblast growth factor receptor binding type 2 fibroblast growth factor receptor binding extracellular region growth factor activity fibroblast growth factor receptor signaling pathway uc007uos.1 uc007uos.2 uc007uos.3 
ENSMUST00000022698.8 Dok2 ENSMUST00000022698.8 docking protein 2, transcript variant 1 (from RefSeq NM_010071.3) Dok2 ENSMUST00000022698.1 ENSMUST00000022698.2 ENSMUST00000022698.3 ENSMUST00000022698.4 ENSMUST00000022698.5 ENSMUST00000022698.6 ENSMUST00000022698.7 NM_010071 Q3TX09 Q3TX09_MOUSE uc007uoy.1 uc007uoy.2 uc007uoy.3 Belongs to the DOK family. Type A subfamily. uc007uoy.1 uc007uoy.2 uc007uoy.3 
ENSMUST00000022699.10 Gfra2 ENSMUST00000022699.10 glial cell line derived neurotrophic factor family receptor alpha 2, transcript variant 1 (from RefSeq NM_008115.3) ENSMUST00000022699.1 ENSMUST00000022699.2 ENSMUST00000022699.3 ENSMUST00000022699.4 ENSMUST00000022699.5 ENSMUST00000022699.6 ENSMUST00000022699.7 ENSMUST00000022699.8 ENSMUST00000022699.9 GFRA2_MOUSE Gdnfrb Gfra2 NM_008115 O08842 Q3UUD8 Q920Y3 Q9Z2A2 Q9Z2A3 Trnr2 uc007uoz.1 uc007uoz.2 uc007uoz.3 uc007uoz.4 The protein encoded by this gene is part of the receptor complex that transduces glial cell-derived neurotrophic factor and neurturin signals by mediating autophosphorylation and activation of the RET receptor. Mice lacking this protein are viable and fertile but display growth retardation attributed to impaired salivary and pancreatic secretion and innervation deficits in the intestinal tract. In addition, knockout mice display neural defects including a failure to initiate outgrowth of dorsal ganglion root neurons, demonstrating a requirement in neuronal differentiation of these cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. [Isoform 2]: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3. Interacts with SORL1. Cell membrane ; Lipid-anchor, GPI-anchor Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist. ; Name=1; Synonyms=Long, 2a IsoId=O08842-1; Sequence=Displayed; Name=2; Synonyms=Short, 2c IsoId=O08842-2; Sequence=VSP_001662; Name=3; Synonyms=2b IsoId=O08842-3; Sequence=VSP_057520; Neurons of the superior cervical and dorsal root ganglia, and adult brain and testis. Low level in the substantia nigra, spleen and adrenal gland (PubMed:9182803). Isoform 1, isoform 2 and isoform 3 are all expressed in brain, liver, ileum, spleen, heart and kidney (PubMed:9875703). In brain, isoform 1 is most abundant, isoform 2 slightly less and isoform 3 is lowest. No significant levels of isoform 1, isoform 2 or isoform 3 expression in testis (PubMed:12829325). Expressed at low level in the ventral mesencephalon at 14 dpc. Highly expressed in the developing dorsal root ganglia (PubMed:9182803). Isoform 1, isoform 2 and isoform 3 are all highly expressed in the late embryonic development (15 dpc and 17 dpc) (PubMed:12829325). Belongs to the GDNFR family. Sequence=AAC53548.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=AAC82464.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=AAC82465.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=AAK97483.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; plasma membrane transmembrane receptor protein tyrosine kinase signaling pathway nervous system development external side of plasma membrane membrane glial cell-derived neurotrophic factor receptor activity anchored component of membrane negative regulation of protein autophosphorylation positive regulation of peptidyl-serine phosphorylation of STAT protein glial cell-derived neurotrophic factor receptor signaling pathway signaling receptor activity receptor complex regulation of peptidyl-serine phosphorylation of STAT protein uc007uoz.1 uc007uoz.2 uc007uoz.3 uc007uoz.4 
ENSMUST00000022701.7 Rb1 ENSMUST00000022701.7 RB transcriptional corepressor 1 (from RefSeq NM_009029.3) ENSMUST00000022701.1 ENSMUST00000022701.2 ENSMUST00000022701.3 ENSMUST00000022701.4 ENSMUST00000022701.5 ENSMUST00000022701.6 NM_009029 P13405 Q4VA62 RB_MOUSE Rb-1 uc007upp.1 uc007upp.2 uc007upp.3 uc007upp.4 Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:8336704). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (PubMed:15750587). Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation (PubMed:16612004). Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1- dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity) (PubMed:15750587, PubMed:16612004, PubMed:8336704). The hypophosphorylated form interacts with and sequesters the E2F1 transcription factor. Interacts with heterodimeric E2F/DP transcription factor complexes containing TFDP1 and either E2F1/E2F, E2F3, E2F4 or E2F5, or TFDP2 and E2F4 (PubMed:8336704, PubMed:20940255). The unphosphorylated form interacts with EID1, ARID3B, KDM5A, SUV39H1, MJD2A/JHDM3A and THOC1. Interacts with the N- terminal domain of TAF1. Interacts with SNW1, ATAD5, AATF, DNMT1, LIN9, LMNA, KMT5B, KMT5C, PELP1, UHRF2, TMPO-alpha and USP4. May interact with NDC80. Interacts with GRIP1 and UBR4. Interacts with ARID4A and KDM5B. Interacts with E4F1 and LIMD1. Interacts with SMARCA4/BRG1 and HDAC1. Interacts with USP4. Interacts (when methylated at Lys-853) with L3MBTL1. Binds to CDK1 and CDK2. Interacts with CHEK2; phosphorylates RB1 (By similarity). Interacts with PRMT2. Interacts with CEBPA. P-TEFB complex interacts with RB1; promotes phosphorylation of RB1 (By similarity). Interacts with RBBP9; the interaction disrupts RB1 binding to E2F1 (By similarity). Interacts with KAT2B/PCAF and EP300/P300 (PubMed:20940255). Interacts with PAX5 (By similarity). (Microbial infection) Interacts with adenovirus E1a protein. (Microbial infection) Interacts with SV40 large T antigen. P13405; Q155P7: Cenpf; NbExp=4; IntAct=EBI-971782, EBI-2211248; P13405; Q80UP3: Dgkz; NbExp=2; IntAct=EBI-971782, EBI-971774; P13405; P17679: Gata1; NbExp=3; IntAct=EBI-971782, EBI-3903251; P13405; Q9R002: Ifi202; NbExp=7; IntAct=EBI-971782, EBI-3043899; P13405; P24610: Pax3; NbExp=3; IntAct=EBI-971782, EBI-1208116; P13405; P52946: Pdx1; NbExp=2; IntAct=EBI-971782, EBI-7128945; P13405; Q3TKT4: Smarca4; NbExp=3; IntAct=EBI-971782, EBI-1210244; P13405; Q61412: Vsx2; NbExp=2; IntAct=EBI-971782, EBI-1208174; P13405; P15976: GATA1; Xeno; NbExp=2; IntAct=EBI-971782, EBI-3909284; Nucleus Note=During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. Expressed in the cell nuclei of renal tubules, hepatocytes and skeletal muscles. Expressed in skin (at protein level) (PubMed:20940255). Phosphorylated (PubMed:8336704). Phosphorylated by CDK6 and CDK4, and subsequently by CDK2 at Ser-561 in G1, thereby releasing E2F1 which is then able to activate cell growth. Dephosphorylated at the late M phase. Phosphorylation of threonine residues in domain C promotes interaction between the C-terminal domain C and the Pocket domain, and thereby inhibits interactions with heterodimeric E2F/DP transcription factor complexes. Dephosphorylated at Ser-788 by calcineruin upon calcium stimulation. CDK3/cyclin-C-mediated phosphorylation at Ser-800 and Ser-804 is required for G0-G1 transition (By similarity). Phosphorylated by CDK1 and CDK2 upon TGFB1-mediated apoptosis (By similarity). Monomethylation at Lys-803 by SMYD2 enhances phosphorylation at Ser-800 and Ser-804, and promotes cell cycle progression. Monomethylation at Lys-853 by SMYD2 promotes interaction with L3MBTL1 (By similarity). N-terminus is methylated by METTL11A/NTM1. Acetylated in the skin (PubMed:20940255). Acetylation at Lys-866 and Lys-867 regulates subcellular localization during keratinocytes differentiation (By similarity). Belongs to the retinoblastoma protein (RB) family. Name=Wikipedia; Note=Retinoblastoma protein entry; URL="https://en.wikipedia.org/wiki/Retinoblastoma_protein"; G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter chromatin core promoter proximal region sequence-specific DNA binding RNA polymerase II regulatory region DNA binding RNA polymerase II activating transcription factor binding regulation of cell growth tissue homeostasis aortic valve morphogenesis DNA binding protein binding nucleus nucleoplasm transcription factor complex spindle chromatin organization regulation of transcription from RNA polymerase II promoter negative regulation of protein kinase activity apoptotic process cell cycle cell cycle arrest Ras protein signal transduction regulation of mitotic cell cycle cyclin/CDK positive transcription elongation factor complex transcription factor binding negative regulation of cell proliferation negative regulation of gene expression PML body enzyme binding kinase binding cell differentiation neuron differentiation sister chromatid biorientation neuron projection development ubiquitin protein ligase binding maintenance of mitotic sister chromatid cohesion glial cell apoptotic process Rb-E2F complex skeletal muscle cell differentiation neuron maturation identical protein binding enucleate erythrocyte differentiation regulation of lipid kinase activity myoblast differentiation positive regulation of macrophage differentiation negative regulation of cell cycle positive regulation of mitotic metaphase/anaphase transition negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter digestive tract development cell morphogenesis involved in neuron differentiation negative regulation of epithelial cell proliferation negative regulation of inflammatory response striated muscle cell differentiation phosphoprotein binding cell division neuron apoptotic process regulation of cell cycle importin-alpha family protein binding protein localization to chromosome, centromeric region cellular response to xenobiotic stimulus negative regulation of protein serine/threonine kinase activity regulation of cohesin loading negative regulation of transcription involved in G1/S transition of mitotic cell cycle hepatocyte apoptotic process disordered domain specific binding negative regulation of tau-protein kinase activity positive regulation of extracellular matrix organization negative regulation of hepatocyte apoptotic process positive regulation of collagen fibril organization negative regulation of myofibroblast differentiation negative regulation of G1/S transition of mitotic cell cycle positive regulation of transcription regulatory region DNA binding negative regulation of apoptotic signaling pathway uc007upp.1 uc007upp.2 uc007upp.3 uc007upp.4 
ENSMUST00000022704.9 Itm2b ENSMUST00000022704.9 integral membrane protein 2B (from RefSeq NM_008410.3) ENSMUST00000022704.1 ENSMUST00000022704.2 ENSMUST00000022704.3 ENSMUST00000022704.4 ENSMUST00000022704.5 ENSMUST00000022704.6 ENSMUST00000022704.7 ENSMUST00000022704.8 ITM2B_MOUSE NM_008410 O89051 Q545S7 uc007upt.1 uc007upt.2 uc007upt.3 uc007upt.4 Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity). Mature BRI2 (mBRI2) functions as a modulator of the amyloid- beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42. Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers. Homodimer; disulfide-linked. Interacts with SPPL2A and SPPL2B. Interacts with APP. Mature BRI2 (mBRI2) interacts with the APP amyloid- beta A4 protein; the interaction occurs at the cell surface and in the endocytic compartments and enable alpha- and beta-secretase-induced APP cleavage inhibition. Mature BRI2 (mBRI2) interacts with the APP C99; the interaction occurs in the endocytic compartments and enable gamma- secretase-induced C99 cleavage inhibition. May form heterodimers with Bri23 peptide and APP amyloid-beta protein 40 (By similarity). Interacts with ADAM7 in sperm; the interaction increases following capacitation (PubMed:20945367). [Integral membrane protein 2B]: Golgi apparatus membrane ; Single-pass type II membrane protein Note=Immature BRI2 (imBRI2) is cleaved by furin in the Golgi into mBRI2 and a Bri23 peptide. mBRI2 is transported to the plasma membrane and Bri23 peptide is secreted. [BRI2, membrane form]: Cell membrane ; Single-pass type II membrane protein Endosome membrane ; Single-pass type II membrane protein Note=Mature BRI2 (mBRI2) needs to be transported from the endoplasmic reticulum compartment to the cell membrane in order to be able to inhibit APP processing. [Bri23 peptide]: Secreted Note=Detected in the cerebral spinal fluid (CSF). [BRI2C, soluble form]: Secreted Expressed in the brain, testis, testicular sperm, epididymis and mature epididymal sperm (at protein level). The ectodomain C-terminal part of the imBRI2 is processed by furin producing a secreted Bri23 peptide and a mature BRI2, membrane form (mBRI2). The remaining part of the ectodomain of mBRI2 containing the BRICHOS domain is cleaved by ADAM10 and is secreted (BRI2C, soluble form). The membrane-bound N-terminal fragment (BRI2C, membrane form) is further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis producing a secreted C-peptide and a BRI2 intracellular domain (BRI2 ICD) released in the cytosol. Shedding by ADAM10 facilitates intramembrane cleavage but is not absolutely required for BRI2 ICD generation (By similarity). Glycosylation at Asn-170 is important for cell surface localization, but doesn't affect furin- and ADAM10-induced proteolytic processing. Belongs to the ITM2 family. Golgi membrane beta-amyloid binding ATP binding extracellular region extracellular space endosome Golgi apparatus plasma membrane endosome membrane membrane integral component of membrane Golgi-associated vesicle membrane integral component of organelle membrane negative regulation of amyloid precursor protein biosynthetic process intracellular membrane-bounded organelle uc007upt.1 uc007upt.2 uc007upt.3 uc007upt.4 
ENSMUST00000022705.7 Med4 ENSMUST00000022705.7 mediator complex subunit 4 (from RefSeq NM_026119.3) ENSMUST00000022705.1 ENSMUST00000022705.2 ENSMUST00000022705.3 ENSMUST00000022705.4 ENSMUST00000022705.5 ENSMUST00000022705.6 MED4_MOUSE NM_026119 Q3UL96 Q8BVG6 Q9CQA5 Vdrip uc007upu.1 uc007upu.2 uc007upu.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQA5-1; Sequence=Displayed; Name=2; IsoId=Q9CQA5-2; Sequence=VSP_027918, VSP_027919; Belongs to the Mediator complex subunit 4 family. Sequence=BAE26554.1; Type=Erroneous initiation; Evidence=; transcription cofactor activity nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter mediator complex positive regulation of transcription, DNA-templated thyroid hormone receptor binding core mediator complex uc007upu.1 uc007upu.2 uc007upu.3 
ENSMUST00000022707.7 Gpc5 ENSMUST00000022707.7 glypican 5 (from RefSeq NM_175500.4) ENSMUST00000022707.1 ENSMUST00000022707.2 ENSMUST00000022707.3 ENSMUST00000022707.4 ENSMUST00000022707.5 ENSMUST00000022707.6 GPC5_MOUSE NM_175500 Q14BN1 Q8CAL5 uc007uyi.1 uc007uyi.2 uc007uyi.3 uc007uyi.4 Cell surface proteoglycan that bears heparan sulfate. Cell membrane ; Lipid-anchor, GPI- anchor ; Extracellular side [Secreted glypican-5]: Secreted, extracellular space Belongs to the glypican family. extracellular region extracellular space Golgi lumen plasma membrane integral component of plasma membrane regulation of signal transduction cell surface membrane cell migration anchored component of membrane anchored component of plasma membrane positive regulation of canonical Wnt signaling pathway regulation of protein localization to membrane uc007uyi.1 uc007uyi.2 uc007uyi.3 uc007uyi.4 
ENSMUST00000022708.7 Trim52 ENSMUST00000022708.7 tripartite motif-containing 52, transcript variant 1 (from RefSeq NM_198601.3) ENSMUST00000022708.1 ENSMUST00000022708.2 ENSMUST00000022708.3 ENSMUST00000022708.4 ENSMUST00000022708.5 ENSMUST00000022708.6 NM_198601 Q8CDV4 Q8CDV4_MOUSE Trim52 uc007uxz.1 uc007uxz.2 uc007uxz.3 molecular_function biological_process nuclear body uc007uxz.1 uc007uxz.2 uc007uxz.3 
ENSMUST00000022709.6 Spry2 ENSMUST00000022709.6 sprouty RTK signaling antagonist 2, transcript variant 1 (from RefSeq NM_011897.4) ENSMUST00000022709.1 ENSMUST00000022709.2 ENSMUST00000022709.3 ENSMUST00000022709.4 ENSMUST00000022709.5 NM_011897 Q9QXV8 Q9WUQ9 SPY2_MOUSE uc007uxy.1 uc007uxy.2 uc007uxy.3 Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (PubMed:10498682, PubMed:10074434, PubMed:29501879). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (PubMed:25576668). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (By similarity). Forms heterodimers with SPRY1 (PubMed:16877379). Forms a tripartite complex containing GAB1, METTL13 and SPRY2 (By similarity). Within the complex interacts with METTL13 (By similarity). Interacts with RAF1 (By similarity). Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction disrupts SPRY2 interaction with GRB2, potentially via disruption of SPRY2 serine dephosphorylation (PubMed:17974561). Interacts with PPP2R1A/PP2A-A and PPP2CA/PP2A-C; the interaction with PPP2CA/PP2A-C is inhibited by interaction with TESK1, possibly by vesicular sequestration of SPRY2 (By similarity). Inhibition of the interaction with the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme results in loss of PP2A-mediated dephosphorylation, resulting in the loss of SPRY2 interaction with GRB2 (By similarity). Interacts with GRB2 (By similarity). Interacts with CBL/C-CBL; the interaction inhibits CBL-mediated ubiquitination of EGFR (By similarity). Interacts (via C-terminus) with CAV1 (via C-terminus) (PubMed:16877379). Cytoplasm, cytoskeleton Cell projection, ruffle membrane Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). Expressed in the testes and brain (at protein level) (PubMed:17974561, PubMed:10074434). In adult, highly expressed in the lung, heart and at lower levels in skeletal muscle and kidney (PubMed:10074434). At 8.5 dpc, expressed in the primitive streak, rostral forebrain, cells lateral to the posterior hindbrain, anterior hindbrain and developing midbrain. At 9.5 dpc, continues to be expressed in the rostral forebrain and primitive streak, and is also detected in the branchial arches and the forelimb bud. At 10.5 dpc, expressed in the somites, frontonasal processes, tailbud, and hindlimb bud (PubMed:10498682). Highly expressed in lung epithelial cells, primarily in the distal airways at 12 dpc (PubMed:10074434). The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles. Cleaved at Pro-143 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Belongs to the sprouty family. establishment of mitotic spindle orientation protein binding nucleus cytoplasm cytosol cytoskeleton microtubule plasma membrane multicellular organism development sensory perception of sound negative regulation of cell proliferation regulation of signal transduction positive regulation of gene expression negative regulation of peptidyl-threonine phosphorylation microtubule cytoskeleton membrane negative regulation of angiogenesis protein kinase binding lung development positive regulation of cell migration negative regulation of cell projection organization ruffle membrane positive regulation of peptidyl-serine phosphorylation negative regulation of GTPase activity cellular response to vascular endothelial growth factor stimulus negative regulation of fibroblast growth factor receptor signaling pathway regulation of cell proliferation inner ear morphogenesis cell projection negative regulation of apoptotic process negative regulation of MAP kinase activity protein serine/threonine kinase activator activity cell fate commitment regulation of cell differentiation negative regulation of Ras protein signal transduction branching morphogenesis of an epithelial tube negative regulation of neurotrophin TRK receptor signaling pathway positive regulation of protein kinase B signaling lung morphogenesis lung growth bud elongation involved in lung branching respiratory system development negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity negative regulation of vascular endothelial growth factor signaling pathway cellular response to leukemia inhibitory factor uc007uxy.1 uc007uxy.2 uc007uxy.3 
ENSMUST00000022715.14 Rbm26 ENSMUST00000022715.14 RNA binding motif protein 26, transcript variant 5 (from RefSeq NR_166779.1) ENSMUST00000022715.1 ENSMUST00000022715.10 ENSMUST00000022715.11 ENSMUST00000022715.12 ENSMUST00000022715.13 ENSMUST00000022715.2 ENSMUST00000022715.3 ENSMUST00000022715.4 ENSMUST00000022715.5 ENSMUST00000022715.6 ENSMUST00000022715.7 ENSMUST00000022715.8 ENSMUST00000022715.9 NR_166779 Q3TA77 Q3UTU9 Q6NZN0 Q8BQ22 Q8C7W9 Q8K101 Q921K4 RBM26_MOUSE Rbm26 uc007uxn.1 uc007uxn.2 uc007uxn.3 May be involved in the turnover of nuclear polyadenylated (pA+) RNA. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q6NZN0-1; Sequence=Displayed; Name=2; IsoId=Q6NZN0-2; Sequence=VSP_022535; Name=3; IsoId=Q6NZN0-3; Sequence=VSP_022533, VSP_022535; Name=4; IsoId=Q6NZN0-4; Sequence=VSP_022533; Name=5; IsoId=Q6NZN0-5; Sequence=VSP_022534; Expressed in testis and ovary. Expressed in testis and ovary at 15.5 dpc. Sequence=AAH29079.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC33537.1; Type=Frameshift; Evidence=; Sequence=BAC34721.1; Type=Frameshift; Evidence=; Sequence=BAE23881.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE42792.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BC066051; Type=Frameshift; Evidence=; nucleic acid binding RNA binding mRNA binding nucleus mRNA processing negative regulation of phosphatase activity positive regulation of RNA export from nucleus metal ion binding uc007uxn.1 uc007uxn.2 uc007uxn.3 
ENSMUST00000022716.4 Obi1 ENSMUST00000022716.4 ORC ubiquitin ligase 1 (from RefSeq NM_026047.4) ENSMUST00000022716.1 ENSMUST00000022716.2 ENSMUST00000022716.3 G3X8V5 G3X8V5_MOUSE NM_026047 Obi1 Rnf219 uc007uxc.1 uc007uxc.2 uc007uxc.3 chromatin chromatin binding ubiquitin-protein transferase activity regulation of DNA replication protein monoubiquitination protein autoubiquitination uc007uxc.1 uc007uxc.2 uc007uxc.3 
ENSMUST00000022718.11 Ednrb ENSMUST00000022718.11 endothelin receptor type B, transcript variant 4 (from RefSeq NM_001422171.1) EDNRB_MOUSE ENSMUST00000022718.1 ENSMUST00000022718.10 ENSMUST00000022718.2 ENSMUST00000022718.3 ENSMUST00000022718.4 ENSMUST00000022718.5 ENSMUST00000022718.6 ENSMUST00000022718.7 ENSMUST00000022718.8 ENSMUST00000022718.9 Ednrb NM_001422171 P48302 Q542M3 uc007uwx.1 uc007uwx.2 uc007uwx.3 uc007uwx.4 uc007uwx.5 Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages. Cell membrane ; Multi-pass membrane protein. Note=internalized after activation by endothelins. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. negative regulation of transcription from RNA polymerase II promoter neural crest cell migration positive regulation of protein phosphorylation G-protein coupled receptor activity endothelin receptor activity protein binding plasma membrane regulation of pH signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration peripheral nervous system development posterior midgut development aging regulation of blood pressure positive regulation of cell proliferation negative regulation of neuron maturation response to organic cyclic compound vein smooth muscle contraction membrane integral component of membrane peptide hormone binding sensory perception of pain calcium-mediated signaling cGMP-mediated signaling melanocyte differentiation regulation of fever generation type 1 angiotensin receptor binding nuclear membrane negative regulation of cellular protein metabolic process response to lipopolysaccharide enteric smooth muscle cell differentiation positive regulation of urine volume positive regulation of renal sodium excretion epithelial fluid transport vasoconstriction vasodilation negative regulation of apoptotic process pigmentation membrane raft developmental pigmentation macrophage chemotaxis response to pain enteric nervous system development regulation of epithelial cell proliferation regulation of sensory perception of pain positive regulation of penile erection cellular response to lipopolysaccharide endothelin receptor signaling pathway response to endothelin uc007uwx.1 uc007uwx.2 uc007uwx.3 uc007uwx.4 uc007uwx.5 
ENSMUST00000022720.15 Fbxl3 ENSMUST00000022720.15 F-box and leucine-rich repeat protein 3, transcript variant 1 (from RefSeq NM_015822.4) Afh ENSMUST00000022720.1 ENSMUST00000022720.10 ENSMUST00000022720.11 ENSMUST00000022720.12 ENSMUST00000022720.13 ENSMUST00000022720.14 ENSMUST00000022720.2 ENSMUST00000022720.3 ENSMUST00000022720.4 ENSMUST00000022720.5 ENSMUST00000022720.6 ENSMUST00000022720.7 ENSMUST00000022720.8 ENSMUST00000022720.9 FBXL3_MOUSE Fbl3a Fbxl3a NM_015822 Ovtm Q80V32 Q8C4V4 Q8K1W0 Q9QXW1 uc007uwj.1 uc007uwj.2 uc007uwj.3 Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. Protein modification; protein ubiquitination. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL3) composed of CUL1, SKP1, RBX1 and FBXL3. Interacts with HDAC3 (PubMed:26776516). Interacts with CRY1 and CRY2 (phosphorylated) (PubMed:23452856, PubMed:30500822). Interacts with KDM8 (PubMed:30500822). Q8C4V4; P97784: Cry1; NbExp=12; IntAct=EBI-1266589, EBI-1266607; Q8C4V4; Q9R194: Cry2; NbExp=6; IntAct=EBI-1266589, EBI-1266619; Q8C4V4; O54943: Per2; NbExp=2; IntAct=EBI-1266589, EBI-1266779; Q8C4V4; Q13616: CUL1; Xeno; NbExp=3; IntAct=EBI-1266589, EBI-359390; Q8C4V4; P63208: SKP1; Xeno; NbExp=3; IntAct=EBI-1266589, EBI-307486; Nucleus Cytoplasm. Note=Predominantly nuclear. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C4V4-1; Sequence=Displayed; Name=2; IsoId=Q8C4V4-2; Sequence=VSP_008414; Ubiquitously expressed but enriched in brain. Diffusely expressed in the suprachiasmatic nucleus, SCN. Undergoes autophagy-mediated degradation in the liver in a time- dependent manner. Mice show defects in behavioral rhythms with an extremely long-period activity phenotype. The onset of active phase is abnormally delayed from the light-to-dark transition: in constant darkness (DD), mice show significantly longer rhythmic activities. Mice lacking both Fbxl3 and Fbxl21 show an attenuated phenotype in behavioral rhythm compared to Fbxl3-deficient mice; however, they exhibit unstable behavioral rhythms, sometimes eliciting arrhythmicity. Sequence=AAF09131.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH46330.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAM92567.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; G2/M transition of mitotic cell cycle ubiquitin-protein transferase activity protein binding nucleus nucleoplasm cytoplasm cytosol protein ubiquitination nuclear body SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein destabilization regulation of circadian rhythm entrainment of circadian clock by photoperiod proteasome-mediated ubiquitin-dependent protein catabolic process rhythmic process regulation of cell cycle ubiquitin protein ligase activity uc007uwj.1 uc007uwj.2 uc007uwj.3 
ENSMUST00000022721.8 Cln5 ENSMUST00000022721.8 ceroid-lipofuscinosis, neuronal 5 (from RefSeq NM_001033242.2) CLN5_MOUSE ENSMUST00000022721.1 ENSMUST00000022721.2 ENSMUST00000022721.3 ENSMUST00000022721.4 ENSMUST00000022721.5 ENSMUST00000022721.6 ENSMUST00000022721.7 NM_001033242 Q3UMW8 Q8C054 Q8R152 uc007uwg.1 uc007uwg.2 uc007uwg.3 Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane. Interacts with PPT1, TPP1, CLN3, CLN6, CLN8, ATP5F1A and ATP5F1B (PubMed:19941651). Interacts with SORT1, RAB5A and RAB7A (By similarity). [Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form]: Lysosome [Ceroid-lipofuscinosis neuronal protein 5 homolog]: Membrane ; Single-pass type II membrane protein Note=An amphipathic anchor region facilitates its association with the membrane. Heart, kidney, liver, spleen, muscle and rectum (at protein level). N-glycosylated with both high mannose and complex type sugars. Glycosylation is important for proper folding and trafficking to the lysosomes. [Ceroid-lipofuscinosis neuronal protein 5 homolog]: The type II membrane signal anchor is proteolytically cleaved to produce a mature form that is transported to the lysosomes (Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form). Can undergo proteolytic cleavage at the C-terminus, probably by a cysteine protease and may involve the removal of approximately 10-15 residues from the C-terminal end (PubMed:26342652). Belongs to the CLN5 family. protein binding mannose binding lysosome lysosomal membrane vacuolar lumen endoplasmic reticulum Golgi apparatus cytosol signal peptide processing lysosome organization lysosomal lumen acidification brain development visual perception membrane integral component of membrane neurogenesis retrograde transport, endosome to Golgi perinuclear region of cytoplasm glycosylation positive regulation of GTP binding uc007uwg.1 uc007uwg.2 uc007uwg.3 
ENSMUST00000022722.7 Acod1 ENSMUST00000022722.7 aconitate decarboxylase 1 (from RefSeq NM_008392.1) A0A0R4J027 A0A0R4J027_MOUSE Acod1 ENSMUST00000022722.1 ENSMUST00000022722.2 ENSMUST00000022722.3 ENSMUST00000022722.4 ENSMUST00000022722.5 ENSMUST00000022722.6 Irg1 NM_008392 uc007uwf.1 uc007uwf.2 uc007uwf.3 uc007uwf.4 Belongs to the PrpD family. positive regulation of antimicrobial humoral response defense response lyase activity aconitate decarboxylase activity cellular response to lipopolysaccharide tolerance induction to lipopolysaccharide uc007uwf.1 uc007uwf.2 uc007uwf.3 uc007uwf.4 
ENSMUST00000022725.4 Dct ENSMUST00000022725.4 dopachrome tautomerase (from RefSeq NM_010024.3) Dct ENSMUST00000022725.1 ENSMUST00000022725.2 ENSMUST00000022725.3 NM_010024 P29812 Q6NXI2 TYRP2_MOUSE Tyrp-2 Tyrp2 uc007uym.1 uc007uym.2 uc007uym.3 uc007uym.4 Plays a role in melanin biosynthesis (PubMed:33100333). Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2- carboxylic acid (DHICA) (PubMed:1537333, PubMed:1537334). Reaction=L-dopachrome = 5,6-dihydroxyindole-2-carboxylate; Xref=Rhea:RHEA:13041, ChEBI:CHEBI:16875, ChEBI:CHEBI:57509; EC=5.3.3.12; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. Pigment biosynthesis; melanin biosynthesis. Forms an OPN3-dependent complex with TYR in response to blue light in melanocytes. Melanosome membrane ; Single-pass type I membrane protein Melanosome Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. Melanocytes and retinal pigmented epithelium (at protein level). Glycosylated. Note=The slaty mutation in Tyrp2 leads to a decrease of DT activity and a consequent change in the pigmentation of the mice to a dark gray/brown eumelanin. The slaty-2j mutation has a similar phenotype, the slaty-lt (light) mutation has a more severe effect and is semidominant; its phenotype may be a result of the failure of the enzyme to be correctly targeted to its normal location on the inner face of the melanosomal membrane. Mutant mice show an hypopigmentation of the coat and have the retinal pigmented epithelium significantly less pigmented than wild-type retinas. Belongs to the tyrosinase family. positive regulation of neuroblast proliferation dopachrome isomerase activity cytoplasm cytosol melanin biosynthetic process from tyrosine membrane integral component of membrane oxidoreductase activity isomerase activity ventricular zone neuroblast division melanosome membrane melanin biosynthetic process melanosome pigmentation metal ion binding developmental pigmentation cell development oxidation-reduction process uc007uym.1 uc007uym.2 uc007uym.3 uc007uym.4 
ENSMUST00000022727.10 Tgds ENSMUST00000022727.10 TDP-glucose 4,6-dehydratase (from RefSeq NM_029578.3) ENSMUST00000022727.1 ENSMUST00000022727.2 ENSMUST00000022727.3 ENSMUST00000022727.4 ENSMUST00000022727.5 ENSMUST00000022727.6 ENSMUST00000022727.7 ENSMUST00000022727.8 ENSMUST00000022727.9 NM_029578 Q3U4A6 Q8VDR7 TGDS_MOUSE uc007uyo.1 uc007uyo.2 uc007uyo.3 uc007uyo.4 Reaction=dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O; Xref=Rhea:RHEA:17221, ChEBI:CHEBI:15377, ChEBI:CHEBI:57477, ChEBI:CHEBI:57649; EC=4.2.1.46; Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence=; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. molecular_function cellular_component biological_process dTDP-glucose 4,6-dehydratase activity nucleotide-sugar metabolic process lyase activity uc007uyo.1 uc007uyo.2 uc007uyo.3 uc007uyo.4 
ENSMUST00000022728.4 Gpr180 ENSMUST00000022728.4 G protein-coupled receptor 180 (from RefSeq NM_021434.5) ENSMUST00000022728.1 ENSMUST00000022728.2 ENSMUST00000022728.3 GP180_MOUSE MNCb-3029 NM_021434 Q8BPS4 Q9JJG1 uc007uyq.1 uc007uyq.2 uc007uyq.3 uc007uyq.4 Membrane ; Multi-pass membrane protein molecular_function G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane response to pheromone uc007uyq.1 uc007uyq.2 uc007uyq.3 uc007uyq.4 
ENSMUST00000022734.9 Dnajc3 ENSMUST00000022734.9 DnaJ heat shock protein family (Hsp40) member C3 (from RefSeq NM_008929.4) DNJC3_MOUSE ENSMUST00000022734.1 ENSMUST00000022734.2 ENSMUST00000022734.3 ENSMUST00000022734.4 ENSMUST00000022734.5 ENSMUST00000022734.6 ENSMUST00000022734.7 ENSMUST00000022734.8 NM_008929 P58ipk Q60873 Q91YW3 uc007uzd.1 uc007uzd.2 uc007uzd.3 uc007uzd.4 Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (PubMed:25329545). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity). Interacts with EIF2AK4/GCN2; this interaction occurs under endoplasmic reticulum (ER) stress, hypothermic and amino acid starving stress conditions and inhibits EIF2AK4/GCN2 kinase activity (PubMed:25329545). Interacts with EIF2AK3 (PubMed:12446838). Interacts with EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with THAP12 (By similarity). Q91YW3; P11021: HSPA5; Xeno; NbExp=2; IntAct=EBI-8381770, EBI-354921; Endoplasmic reticulum Widely expressed, with high level in the liver. Up-regulated during an endoplasmic reticulum stress. The J domain mediates interaction with HSPA8. Binding to misfolded proteins is mediated by a hydrophobic patch forming a large groove within the first two TPR repeats. protein kinase inhibitor activity protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum lumen smooth endoplasmic reticulum cytosol regulation of translation negative regulation of protein kinase activity response to unfolded protein protein kinase binding endoplasmic reticulum unfolded protein response protein folding in endoplasmic reticulum response to endoplasmic reticulum stress positive regulation of translation initiation in response to endoplasmic reticulum stress negative regulation of apoptotic process chaperone binding proteolysis involved in cellular protein catabolic process misfolded protein binding cellular response to cold negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation uc007uzd.1 uc007uzd.2 uc007uzd.3 uc007uzd.4 
ENSMUST00000022744.5 Gdnf ENSMUST00000022744.5 glial cell line derived neurotrophic factor, transcript variant 1 (from RefSeq NM_010275.3) ENSMUST00000022744.1 ENSMUST00000022744.2 ENSMUST00000022744.3 ENSMUST00000022744.4 GDNF_MOUSE NM_010275 O09058 P48540 P70446 P97919 P97920 Q6LEL9 uc007vee.1 uc007vee.2 uc007vee.3 uc007vee.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Homozygous knockout mice for this gene exhibit defects in kidney development and neonatal death. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]. Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. Homodimer; disulfide-linked (By similarity). Interacts with RET (By similarity). Interacts (via propeptide) with SORL1 (via N- terminal ectodomain), either alone or in complex with GFRA1; interaction with SORL1 affects GDNF-regulated, but not constitutive secretion (PubMed:21994944). Also interacts with SORL1 in complex with GFRA1; this interaction leads to GDNF endocytosis and lysosomal degradation (By similarity). Secreted Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=GDNF-alpha; IsoId=P48540-1; Sequence=Displayed; Name=2; Synonyms=GDNF-beta; IsoId=P48540-2; Sequence=VSP_026367, VSP_006421; Name=3; IsoId=P48540-3; Sequence=VSP_026367; Expressed in both the central nervous system (CNS) and in non-CNS tissues. Expressed in a highly dynamic pattern in the anterior neuroectoderm during the early stages of neurogenesis between 7.5 dpc and 10.5 dpc. Beginning at 10.5 dpc, expression begins in mesenchymal tissues of several organs including the digestive tract, kidney, testis, frontonasal mass, tooth primordium, tongue, mandible, whisker follicles, ear, eye, limb bud and in distinct regions of the brain. Also expressed in the heart, ileum, liver and muscle. First detected at 7.5 dpc, reaches its peak around 9.5 dpc and declines considerably after 10.5 dpc. Expression in C6 glioma cells was transiently induced by treatment with phorbol myristate acetate (PMA), but not by forskolin. Belongs to the TGF-beta family. GDNF subfamily. metanephros development ureteric bud development branching involved in ureteric bud morphogenesis neural crest cell migration organ induction postsynaptic membrane organization mesenchymal to epithelial transition involved in metanephros morphogenesis transforming growth factor beta receptor binding extracellular region extracellular space Golgi apparatus transmembrane receptor protein tyrosine kinase signaling pathway transforming growth factor beta receptor signaling pathway nervous system development peripheral nervous system development growth factor activity cell proliferation positive regulation of cell proliferation response to wounding regulation of gene expression dorsal spinal cord development postganglionic parasympathetic fiber development glial cell-derived neurotrophic factor receptor binding neuron differentiation peristalsis receptor tyrosine kinase binding neuron projection development positive regulation of monooxygenase activity protein homodimerization activity receptor complex negative regulation of neuron apoptotic process positive regulation of cell differentiation positive regulation of transcription from RNA polymerase II promoter receptor agonist activity mRNA stabilization enteric nervous system development sympathetic nervous system development embryonic organ development positive regulation of peptidyl-tyrosine phosphorylation regulation of dopamine uptake involved in synaptic transmission ureteric bud formation regulation of morphogenesis of a branching structure cellular response to dexamethasone stimulus commissural neuron axon guidance regulation of ureteric bud formation positive regulation of ureteric bud formation positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis positive regulation of branching involved in ureteric bud morphogenesis neural crest cell migration involved in autonomic nervous system development negative regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of semaphorin-plexin signaling pathway uc007vee.1 uc007vee.2 uc007vee.3 uc007vee.4 
ENSMUST00000022749.17 C9 ENSMUST00000022749.17 complement component 9, transcript variant 1 (from RefSeq NM_013485.3) CO9_MOUSE ENSMUST00000022749.1 ENSMUST00000022749.10 ENSMUST00000022749.11 ENSMUST00000022749.12 ENSMUST00000022749.13 ENSMUST00000022749.14 ENSMUST00000022749.15 ENSMUST00000022749.16 ENSMUST00000022749.2 ENSMUST00000022749.3 ENSMUST00000022749.4 ENSMUST00000022749.5 ENSMUST00000022749.6 ENSMUST00000022749.7 ENSMUST00000022749.8 ENSMUST00000022749.9 NM_013485 P06683 Q91XA7 uc007vdh.1 uc007vdh.2 uc007vdh.3 Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. About 20 C9 chains oligomerize to give rise to a huge beta-barrel that forms a 100 Angstrom diameter pore in target membranes. Secreted Target cell membrane ; Multi-pass membrane protein Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore. Initially, positions and connectivity of disulfide bonds were based on peptide sequencing done for the human protein. The high- resolution crystal structure for the mouse protein corrected the positions and connectivities of some disulfide bonds (PubMed:30111885). The distance between Cys-55 and Cys-92 in the monomeric mouse protein precludes formation of a disulfide bond, contrary to what is seen in the structure of the human polymeric form of the protein (Probable). Belongs to the complement C6/C7/C8/C9 family. Sequence=AAH11137.1; Type=Erroneous initiation; Evidence=; cell killing immune system process extracellular region membrane attack complex extracellular space cytosol plasma membrane immune response complement activation, alternative pathway complement activation, classical pathway blood coagulation membrane integral component of membrane cytolysis other organism cell membrane innate immune response protein homooligomerization uc007vdh.1 uc007vdh.2 uc007vdh.3 
ENSMUST00000022757.5 Gzmf ENSMUST00000022757.5 granzyme F (from RefSeq NM_010374.3) ENSMUST00000022757.1 ENSMUST00000022757.2 ENSMUST00000022757.3 ENSMUST00000022757.4 Gzmf NM_010374 Q497Z7 Q497Z7_MOUSE uc007ubs.1 uc007ubs.2 uc007ubs.3 Cytolytic granule serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc007ubs.1 uc007ubs.2 uc007ubs.3 
ENSMUST00000022765.14 Rab2b ENSMUST00000022765.14 RAB2B, member RAS oncogene family (from RefSeq NM_172601.3) ENSMUST00000022765.1 ENSMUST00000022765.10 ENSMUST00000022765.11 ENSMUST00000022765.12 ENSMUST00000022765.13 ENSMUST00000022765.2 ENSMUST00000022765.3 ENSMUST00000022765.4 ENSMUST00000022765.5 ENSMUST00000022765.6 ENSMUST00000022765.7 ENSMUST00000022765.8 ENSMUST00000022765.9 NM_172601 Q0PD64 Q0PD64_MOUSE Rab2B Rab2b uc007tox.1 uc007tox.2 uc007tox.3 uc007tox.4 Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding positive regulation of exocytosis presynapse uc007tox.1 uc007tox.2 uc007tox.3 uc007tox.4 
ENSMUST00000022766.8 Tox4 ENSMUST00000022766.8 TOX high mobility group box family member 4 (from RefSeq NM_023434.3) ENSMUST00000022766.1 ENSMUST00000022766.2 ENSMUST00000022766.3 ENSMUST00000022766.4 ENSMUST00000022766.5 ENSMUST00000022766.6 ENSMUST00000022766.7 NM_023434 Q3UGN7 Q80UI2 Q8BU11 Q99PN9 Q9CS16 TOX4_MOUSE uc007tpa.1 uc007tpa.2 uc007tpa.3 uc007tpa.4 Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (PubMed:31519808). Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1. This regulation is independent of the insulin receptor activation (PubMed:34914893). In liver, recruited to target gene promoters following treatment with dexamethasone and cAMP. Binding is decreased in presence of insulin. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS (By similarity). Interacts with FOXO1 and CREB1 (increased by cAMP); FOXO1 and CREB1 are required for full induction of TOX4-dependent activity and the interactions are inhibited by insulin (PubMed:34914893). Nucleus Note=Associated with chromatin. In liver, expression is increased upon high fat diet. Conditional knockout in liver lead to no 10% reduction of glucose levels after 4 hours of fasting with an improvement of glucose tolerance and an increased insulin sensitivity. nuclear chromosome, telomeric region chromatin DNA binding nucleus PTW/PP1 phosphatase complex uc007tpa.1 uc007tpa.2 uc007tpa.3 uc007tpa.4 
ENSMUST00000022767.16 Mettl3 ENSMUST00000022767.16 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit (from RefSeq NM_019721.2) A0A0R4J041 A0A0R4J041_MOUSE ENSMUST00000022767.1 ENSMUST00000022767.10 ENSMUST00000022767.11 ENSMUST00000022767.12 ENSMUST00000022767.13 ENSMUST00000022767.14 ENSMUST00000022767.15 ENSMUST00000022767.2 ENSMUST00000022767.3 ENSMUST00000022767.4 ENSMUST00000022767.5 ENSMUST00000022767.6 ENSMUST00000022767.7 ENSMUST00000022767.8 ENSMUST00000022767.9 Mettl3 NM_019721 uc007tpc.1 uc007tpc.2 uc007tpc.3 uc007tpc.4 Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)- methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348; Evidence=; Belongs to the MT-A70-like family. mRNA splicing, via spliceosome RNA methylation mRNA (N6-adenosine)-methyltransferase activity mRNA binding nucleus cellular response to DNA damage stimulus RNA methyltransferase activity dosage compensation by inactivation of X chromosome mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity nuclear speck primary miRNA processing cellular response to UV MIS complex positive regulation of translation protein heterodimerization activity negative regulation of type I interferon-mediated signaling pathway mRNA methylation positive regulation of cap-independent translational initiation S-adenosyl-L-methionine binding primary miRNA methylation uc007tpc.1 uc007tpc.2 uc007tpc.3 uc007tpc.4 
ENSMUST00000022781.8 Dad1 ENSMUST00000022781.8 defender against cell death 1, transcript variant 1 (from RefSeq NM_001113358.1) DAD1_MOUSE Dad1 ENSMUST00000022781.1 ENSMUST00000022781.2 ENSMUST00000022781.3 ENSMUST00000022781.4 ENSMUST00000022781.5 ENSMUST00000022781.6 ENSMUST00000022781.7 NM_001113358 O08552 O70364 P46966 P46968 P61804 Q3V3W6 Q96GB7 uc007tvm.1 uc007tvm.2 uc007tvm.3 uc007tvm.4 Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Protein modification; protein glycosylation. Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Endoplasmic reticulum membrane; Multi-pass membrane protein Belongs to the DAD/OST2 family. blastocyst development dolichyl-diphosphooligosaccharide-protein glycotransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation protein N-linked glycosylation apoptotic process response to nutrient oligosaccharyltransferase complex membrane integral component of membrane response to drug negative regulation of apoptotic process oligosaccharyl transferase activity uc007tvm.1 uc007tvm.2 uc007tvm.3 uc007tvm.4 
ENSMUST00000022782.10 Lrp10 ENSMUST00000022782.10 low-density lipoprotein receptor-related protein 10 (from RefSeq NM_022993.3) ENSMUST00000022782.1 ENSMUST00000022782.2 ENSMUST00000022782.3 ENSMUST00000022782.4 ENSMUST00000022782.5 ENSMUST00000022782.6 ENSMUST00000022782.7 ENSMUST00000022782.8 ENSMUST00000022782.9 LRP10_MOUSE Lrp9 NM_022993 Q3UNT0 Q7TQH7 Q7TS95 Q921T0 Q9EPE8 uc007twd.1 uc007twd.2 uc007twd.3 uc007twd.4 Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver. Membrane ; Single-pass type I membrane protein Membrane, coated pit Highly expressed in heart, lung, liver and liver. Expressed at low level in brain and spleen. Weakly or not expressed in testis and skeletal muscle. In liver, it is expressed in hepatocytes and at higher level in sinusoidal lining. In the kidney, it is expressed in peritubular capillaries. In brain, it is expressed in the epithelium of the choroid plexus ependymal cells of the third ventricle pia matter, and to lesser extent in hippocampal fields CA2 and CA3. Belongs to the LDLR family. Sequence=AAH11058.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; low-density lipoprotein receptor activity clathrin-coated pit lipid metabolic process lipid transport endocytosis membrane integral component of membrane inner ear development uc007twd.1 uc007twd.2 uc007twd.3 uc007twd.4 
ENSMUST00000022784.9 Haus4 ENSMUST00000022784.9 HAUS augmin-like complex, subunit 4 (from RefSeq NM_145462.2) D14Ertd500e ENSMUST00000022784.1 ENSMUST00000022784.2 ENSMUST00000022784.3 ENSMUST00000022784.4 ENSMUST00000022784.5 ENSMUST00000022784.6 ENSMUST00000022784.7 ENSMUST00000022784.8 HAUS4_MOUSE NM_145462 Q8BFT2 Q99KI1 uc007twh.1 uc007twh.2 uc007twh.3 Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly (By similarity). Interacts with EML3 (phosphorylated at 'Thr-882') (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. Belongs to the HAUS4 family. molecular_function cytoplasm centrosome microtubule organizing center spindle cytoskeleton microtubule cell cycle centrosome cycle microtubule minus-end binding spindle assembly cell division HAUS complex uc007twh.1 uc007twh.2 uc007twh.3 
ENSMUST00000022786.6 4931414P19Rik ENSMUST00000022786.6 RIKEN cDNA 4931414P19 gene (from RefSeq NM_028890.2) CN093_MOUSE ENSMUST00000022786.1 ENSMUST00000022786.2 ENSMUST00000022786.3 ENSMUST00000022786.4 ENSMUST00000022786.5 NM_028890 Q8K2W9 uc007twk.1 uc007twk.2 uc007twk.3 Secreted cellular_component extracellular region biological_process uc007twk.1 uc007twk.2 uc007twk.3 
ENSMUST00000022787.8 Slc7a8 ENSMUST00000022787.8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 (from RefSeq NM_016972.2) ENSMUST00000022787.1 ENSMUST00000022787.2 ENSMUST00000022787.3 ENSMUST00000022787.4 ENSMUST00000022787.5 ENSMUST00000022787.6 ENSMUST00000022787.7 LAT2_MOUSE Lat2 NM_016972 Q9QXW9 uc007txa.1 uc007txa.2 uc007txa.3 Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1 (PubMed:10574970). Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids. Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter. This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake. May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (By similarity). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (PubMed:26601072, PubMed:28108384). Mediates the uptake of L-DOPA (By similarity). May participate in auditory function (PubMed:29355479). Reaction=L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L- phenylalanine(in); Xref=Rhea:RHEA:71003, ChEBI:CHEBI:57595, ChEBI:CHEBI:58095; Evidence=; Reaction=L-phenylalanine(out) + L-tryptophan(in) = L-phenylalanine(in) + L-tryptophan(out); Xref=Rhea:RHEA:71007, ChEBI:CHEBI:57912, ChEBI:CHEBI:58095; Evidence=; Reaction=L-isoleucine(in) + L-phenylalanine(out) = L-isoleucine(out) + L-phenylalanine(in); Xref=Rhea:RHEA:71011, ChEBI:CHEBI:58045, ChEBI:CHEBI:58095; Evidence=; Reaction=L-phenylalanine(out) + L-valine(in) = L-phenylalanine(in) + L- valine(out); Xref=Rhea:RHEA:71019, ChEBI:CHEBI:57762, ChEBI:CHEBI:58095; Evidence=; Reaction=L-leucine(in) + L-phenylalanine(out) = L-leucine(out) + L- phenylalanine(in); Xref=Rhea:RHEA:71023, ChEBI:CHEBI:57427, ChEBI:CHEBI:58095; Evidence=; Reaction=L-glutamine(in) + L-phenylalanine(out) = L-glutamine(out) + L- phenylalanine(in); Xref=Rhea:RHEA:71027, ChEBI:CHEBI:58095, ChEBI:CHEBI:58359; Evidence=; Reaction=L-cysteine(in) + L-phenylalanine(out) = L-cysteine(out) + L- phenylalanine(in); Xref=Rhea:RHEA:71031, ChEBI:CHEBI:35235, ChEBI:CHEBI:58095; Evidence=; Reaction=L-methionine(in) + L-phenylalanine(out) = L-methionine(out) + L-phenylalanine(in); Xref=Rhea:RHEA:71039, ChEBI:CHEBI:57844, ChEBI:CHEBI:58095; Evidence=; Reaction=L-leucine(out) + L-methionine(in) = L-leucine(in) + L- methionine(out); Xref=Rhea:RHEA:71051, ChEBI:CHEBI:57427, ChEBI:CHEBI:57844; Evidence=; Reaction=L-cysteine(out) + L-methionine(in) = L-cysteine(in) + L- methionine(out); Xref=Rhea:RHEA:71055, ChEBI:CHEBI:35235, ChEBI:CHEBI:57844; Evidence=; Reaction=L-methionine(in) + S-methylmercury-L-cysteine(out) = L- methionine(out) + S-methylmercury-L-cysteine(in); Xref=Rhea:RHEA:71103, ChEBI:CHEBI:57844, ChEBI:CHEBI:190186; Evidence=; Reaction=L-leucine(out) + S-methylmercury-L-cysteine(in) = L- leucine(in) + S-methylmercury-L-cysteine(out); Xref=Rhea:RHEA:71107, ChEBI:CHEBI:57427, ChEBI:CHEBI:190186; Evidence=; Reaction=L-phenylalanine(out) + S-methylmercury-L-cysteine(in) = L- phenylalanine(in) + S-methylmercury-L-cysteine(out); Xref=Rhea:RHEA:71111, ChEBI:CHEBI:58095, ChEBI:CHEBI:190186; Evidence=; Reaction=L-phenylalanine(out) + L-serine(in) = L-phenylalanine(in) + L- serine(out); Xref=Rhea:RHEA:71035, ChEBI:CHEBI:33384, ChEBI:CHEBI:58095; Evidence=; Reaction=glycine(in) + L-phenylalanine(out) = glycine(out) + L- phenylalanine(in); Xref=Rhea:RHEA:71047, ChEBI:CHEBI:57305, ChEBI:CHEBI:58095; Evidence=; Reaction=L-alanine(in) + L-phenylalanine(out) = L-alanine(out) + L- phenylalanine(in); Xref=Rhea:RHEA:71043, ChEBI:CHEBI:57972, ChEBI:CHEBI:58095; Evidence=; Reaction=L-tryptophan(in) = L-tryptophan(out); Xref=Rhea:RHEA:70947, ChEBI:CHEBI:57912; Evidence=; Reaction=3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L- thyronine(in); Xref=Rhea:RHEA:71811, ChEBI:CHEBI:533015; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71812; Evidence=; Reaction=3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in); Xref=Rhea:RHEA:71823, ChEBI:CHEBI:176514; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71824; Evidence=; Reaction=L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L- phenylalanine(out); Xref=Rhea:RHEA:71439, ChEBI:CHEBI:57504, ChEBI:CHEBI:58095; Evidence=; Kinetic parameters: KM=12.2 uM for L-phenylalanine ; KM=48 uM for L-leucine ; KM=167 uM for L-alanine ; KM=294 uM for L-histidine ; KM=275 uM for L-glutamine ; KM=16.2 uM for 3,3'-diiodo-L-thyronine ; KM=18.6 uM for 3,3'-diiodo-L-thyronine ; Disulfide-linked heterodimer composed of the catalytic light chain subunit SLC7A8 and the heavy chain subunit SLC3A2 (PubMed:10574970). SLC3A2 acts as a chaperone for correct plasma membrane trafficking and stabilization of SLC7A8 and modulates the substrate affinity and specificity of SLC7A8. ICAM-1 associates with the heterodimer SLC3A2/SLC7A8; facilitates leucine uptake (By similarity). Cell membrane ulti-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Note=When coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi. Strongly expressed in kidney and small intestine. Moderately present in placenta, ovary and brain (PubMed:10574970, PubMed:29355479). Expressed in the inner ear (PubMed:29355479). Slc7a8-deficient mice present normal development and growth. Only a slightly altered coordination of movements is observed in Slc7a8-deficient mice. Circulating thyroid hormones, thyrotropin and thyroid hormone-responsive genes remain unchange. Functional compensation by other amino acid transporters might explain the lack of a severe phenotype (PubMed:21726201). The lack of Slc7a8 results in a significant increase of cataracts in old animals, in particularly in old females (PubMed:31231240). Slc7a8-deficient mice dysplay a hearing loss defect with incomplete penetrance affecting mainly high-frequency sounds, hearing loss severity increases with age in Slc7a8-deficient mice (PubMed:29355479). Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. amino acid transmembrane transport amine transmembrane transporter activity cytoplasm plasma membrane amino acid transport organic cation transmembrane transporter activity amino acid transmembrane transporter activity neutral amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity organic cation transport neutral amino acid transport L-amino acid transport amine transport membrane integral component of membrane basolateral plasma membrane toxin transporter activity transmembrane transporter activity transmembrane transport toxin transport L-alpha-amino acid transmembrane transport uc007txa.1 uc007txa.2 uc007txa.3 
ENSMUST00000022791.9 Fbxo4 ENSMUST00000022791.9 F-box protein 4 (from RefSeq NM_134099.2) E9QPM9 ENSMUST00000022791.1 ENSMUST00000022791.2 ENSMUST00000022791.3 ENSMUST00000022791.4 ENSMUST00000022791.5 ENSMUST00000022791.6 ENSMUST00000022791.7 ENSMUST00000022791.8 FBX4_MOUSE Fbx4 Fbxo4 NM_134099 Q8CHQ0 Q99JG8 uc007vcf.1 uc007vcf.2 uc007vcf.3 uc007vcf.4 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17081987, PubMed:18598945, PubMed:19767775, PubMed:29142209). Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation (PubMed:17081987, PubMed:18598945, PubMed:19767775). Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome (PubMed:29142209). Protein modification; protein ubiquitination. Homodimer (By similarity). Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO4) formed of CUL1, SKP1, RBX1 and FBXO4 (PubMed:17081987). Interacts with TERF1; this interaction is prevented in the presence of GNL3L (PubMed:19487455). Identified in a complex with CRYAB and CCND1 (PubMed:17081987). Q8CHQ0; P62259: Ywhae; NbExp=2; IntAct=EBI-3895153, EBI-356480; Cytoplasm Phosphorylation at Ser-11 varies during the cell cycle. It is low in resting cells and high in the S phase and the G2/M phase of the cell cycle. Phosphorylation is decreased during late G1 phase. Phosphorylation at Ser-11 is important for homodimerization and for optimal ubiquitin ligase activity towards CCND1. ubiquitin ligase complex protein polyubiquitination telomere maintenance ubiquitin-protein transferase activity protein binding cytoplasm ubiquitin-dependent protein catabolic process aging posttranscriptional regulation of gene expression protein ubiquitination SCF ubiquitin ligase complex cellular homeostasis SCF-dependent proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination regulation of protein stability protein destabilization positive regulation of telomere maintenance via telomerase common myeloid progenitor cell proliferation protein homodimerization activity negative regulation of fibroblast proliferation ubiquitin protein ligase activity cellular response to ionizing radiation negative regulation of protein localization to nucleus positive regulation of protein polyubiquitination regulation of DNA damage checkpoint uc007vcf.1 uc007vcf.2 uc007vcf.3 uc007vcf.4 
ENSMUST00000022803.6 Psmb5 ENSMUST00000022803.6 proteasome (prosome, macropain) subunit, beta type 5 (from RefSeq NM_011186.1) ENSMUST00000022803.1 ENSMUST00000022803.2 ENSMUST00000022803.3 ENSMUST00000022803.4 ENSMUST00000022803.5 NM_011186 O55234 PSB5_MOUSE Q3UZI1 Q91X53 Q9CWR4 Q9R1P2 uc007twl.1 uc007twl.2 uc007twl.3 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; Evidence=; The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:16857966, PubMed:22341445). Directly interacts with POMP (By similarity). Interacts with ABCB1 and TAP1 (By similarity). Cytoplasm Nucleus Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. Expressed in uterus at the embryo implantation site. Up-regulated in embryonic fibroblasts and neuroblastoma cells by antioxidants through the Nrf2-ARE pathway (at protein level). Up-regulated by the antioxidant dithiolethione (D3T) in liver, small intestine and brain (at protein level). Down-regulated under lithium treatment. Belongs to the peptidase T1B family. proteasome complex endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm centrosome cytosol proteasome core complex proteolysis response to oxidative stress peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, beta-subunit complex proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process uc007twl.1 uc007twl.2 uc007twl.3 
ENSMUST00000022806.10 Bcl2l2 ENSMUST00000022806.10 BCL2-like 2, transcript variant 1 (from RefSeq NM_007537.2) B2CL2_MOUSE Bclw ENSMUST00000022806.1 ENSMUST00000022806.2 ENSMUST00000022806.3 ENSMUST00000022806.4 ENSMUST00000022806.5 ENSMUST00000022806.6 ENSMUST00000022806.7 ENSMUST00000022806.8 ENSMUST00000022806.9 Kiaa0271 NM_007537 P70345 Q545Q4 Q6A093 Q8CFR2 Q8CGL4 Q9CYW5 uc007txe.1 uc007txe.2 uc007txe.3 Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Interacts with HIF3A isoform 2 (via C-terminus domain) (PubMed:21546903). Interacts with BOP (By similarity). Mitochondrion membrane ; Peripheral membrane protein Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70345-1; Sequence=Displayed; Name=2; IsoId=P70345-2; Sequence=VSP_014780; Expressed in almost all myeloid cell lines and in a wide range of tissues, with highest levels in brain, colon, and salivary gland. Expressed in both mitotic and postmitotic Sertoli cells. By Igf1. The BH4 motif seems to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2 (By similarity). Mice are sterile due to arrest in spermatogenesis associated with a gradual loss of germ and Sertoli cells from the testis. Belongs to the Bcl-2 family. Sequence=BAD32203.1; Type=Frameshift; Evidence=; protein binding cytoplasm mitochondrion mitochondrial outer membrane cytosol apoptotic process intrinsic apoptotic signaling pathway in response to DNA damage membrane mitochondrial membrane negative regulation of mitochondrial membrane permeability identical protein binding protein homodimerization activity regulation of apoptotic process negative regulation of apoptotic process protein heterodimerization activity BH domain binding Sertoli cell proliferation cellular response to estradiol stimulus negative regulation of release of cytochrome c from mitochondria Bcl-2 family protein complex extrinsic apoptotic signaling pathway in absence of ligand disordered domain specific binding cellular response to beta-amyloid negative regulation of intrinsic apoptotic signaling pathway uc007txe.1 uc007txe.2 uc007txe.3 
ENSMUST00000022813.8 Efs ENSMUST00000022813.8 embryonal Fyn-associated substrate, transcript variant 1 (from RefSeq NM_010112.5) EFS_MOUSE ENSMUST00000022813.1 ENSMUST00000022813.2 ENSMUST00000022813.3 ENSMUST00000022813.4 ENSMUST00000022813.5 ENSMUST00000022813.6 ENSMUST00000022813.7 NM_010112 Q64355 Q8BSX4 Sin uc007txm.1 uc007txm.2 uc007txm.3 uc007txm.4 Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES. Widely expressed. Higher levels found in placenta and embryo. Lower levels found in brain, brainstem, muscle and lung. No expression in liver and intestine. Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The SH3-binding sites that bind to the SRC SH3 domain are required for interaction with CRK and are implicated in promotion of serum response element (SRE) activation. The SH3 domain interacts with PTK2/FAK1. Phosphorylated on multiple tyrosine residues. Phosphorylated on tyrosines by FYN and SRC. Belongs to the CAS family. cytoplasm cell adhesion cell migration SH3 domain binding protein domain specific binding actin filament reorganization plasma membrane uc007txm.1 uc007txm.2 uc007txm.3 uc007txm.4 
ENSMUST00000022815.10 Ngdn ENSMUST00000022815.10 neuroguidin, EIF4E binding protein (from RefSeq NM_026890.2) ENSMUST00000022815.1 ENSMUST00000022815.2 ENSMUST00000022815.3 ENSMUST00000022815.4 ENSMUST00000022815.5 ENSMUST00000022815.6 ENSMUST00000022815.7 ENSMUST00000022815.8 ENSMUST00000022815.9 NGDN_MOUSE NM_026890 Ngd Q8CIJ2 Q9DB96 uc007txx.1 uc007txx.2 uc007txx.3 uc007txx.4 uc007txx.5 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (By similarity). Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (PubMed:16705177). Interacts with CPEB1 and EIF4E. Nucleus Nucleus, nucleolus Chromosome, centromere Cytoplasm Cell projection, axon Cell projection, dendrite Cell projection, filopodium Note=Translocated from nucleolus to nuclear foci in response to UV damage (By similarity). Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites. Expressed in testis, ovary, spleen, kidney, hippocampus and cerebellum (at protein level). Expressed in testis, ovary, spleen, kidney, brain. Belongs to the SAS10 family. Sequence=AAH23770.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) chromosome, centromeric region nucleus chromosome nucleolus cytoplasm mitochondrion regulation of translation filopodium axon dendrite small-subunit processome cell projection uc007txx.1 uc007txx.2 uc007txx.3 uc007txx.4 uc007txx.5 
ENSMUST00000022816.15 Sub1 ENSMUST00000022816.15 SUB1 homolog, transcriptional regulator, transcript variant 1 (from RefSeq NM_011294.4) ENSMUST00000022816.1 ENSMUST00000022816.10 ENSMUST00000022816.11 ENSMUST00000022816.12 ENSMUST00000022816.13 ENSMUST00000022816.14 ENSMUST00000022816.2 ENSMUST00000022816.3 ENSMUST00000022816.4 ENSMUST00000022816.5 ENSMUST00000022816.6 ENSMUST00000022816.7 ENSMUST00000022816.8 ENSMUST00000022816.9 NM_011294 P11031 Pc4 Q3UJR5 Q543N2 Rpo2tc1 TCP4_MOUSE uc007vhj.1 uc007vhj.2 uc007vhj.3 General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). Homodimer. Interacts with CSTF2 (By similarity). Nucleus. Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA (By similarity). Belongs to the transcriptional coactivator PC4 family. RNA polymerase II distal enhancer sequence-specific DNA binding DNA binding DNA helicase activity double-stranded DNA binding single-stranded DNA binding transcription coactivator activity nucleus transcription factor complex nucleolus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter DNA duplex unwinding activating transcription factor binding identical protein binding protein homooligomerization positive regulation of transcription initiation from RNA polymerase II promoter SMAD protein signal transduction uc007vhj.1 uc007vhj.2 uc007vhj.3 
ENSMUST00000022819.13 Jph4 ENSMUST00000022819.13 junctophilin 4 (from RefSeq NM_177049.5) ENSMUST00000022819.1 ENSMUST00000022819.10 ENSMUST00000022819.11 ENSMUST00000022819.12 ENSMUST00000022819.2 ENSMUST00000022819.3 ENSMUST00000022819.4 ENSMUST00000022819.5 ENSMUST00000022819.6 ENSMUST00000022819.7 ENSMUST00000022819.8 ENSMUST00000022819.9 JPH4_MOUSE Jphl1 NM_177049 Q69FB2 Q80WT0 Q8BMI1 uc007tyh.1 uc007tyh.2 uc007tyh.3 Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. Cell membrane ; Peripheral membrane protein Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80WT0-1; Sequence=Displayed; Name=2; IsoId=Q80WT0-2; Sequence=VSP_008197, VSP_008198; Specifically expressed in brain. Highest levels in the olfactory tubercle, caudate putamen, nucleus accumbens, hippocampal formation, piriform cortex and cerebellar cortex. Expressed in disctete neurons sites. In hippocampal formation, expressed in dendrites of hippocampal pyramidal and denate granule cells. In cerebellum, it is highly expressed in Purkinje cells, while it is weakly expressed in granular cells. The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids. Jph3 and Jph4 double null mutants exhibit atypical depolarizing responses, irregular cerebellar plasticity due to abolished crosstalk in Purkinje cells. There is hyperphosphorylation of PRKCG and mild impairment of synaptic maturation. Exploratory activity, hippocampal plasticity and memory are impaired and there is abnormal foot-clasping reflex. [Isoform 2]: Due to intron retention. Belongs to the junctophilin family. regulation of cytokine production endoplasmic reticulum endoplasmic reticulum membrane smooth endoplasmic reticulum plasma membrane learning calcium-release channel activity membrane integral component of membrane junctional membrane complex dendritic shaft regulation of synaptic plasticity neuromuscular process controlling balance release of sequestered calcium ion into cytosol regulation of store-operated calcium entry uc007tyh.1 uc007tyh.2 uc007tyh.3 
ENSMUST00000022820.12 Dhrs2 ENSMUST00000022820.12 dehydrogenase/reductase member 2 (from RefSeq NM_027790.2) Dhrs2 ENSMUST00000022820.1 ENSMUST00000022820.10 ENSMUST00000022820.11 ENSMUST00000022820.2 ENSMUST00000022820.3 ENSMUST00000022820.4 ENSMUST00000022820.5 ENSMUST00000022820.6 ENSMUST00000022820.7 ENSMUST00000022820.8 ENSMUST00000022820.9 NM_027790 Q149L0 Q149L0_MOUSE uc007tyk.1 uc007tyk.2 uc007tyk.3 uc007tyk.4 Belongs to the short-chain dehydrogenases/reductases (SDR) family. molecular_function carbonyl reductase (NADPH) activity cellular_component nucleus nuclear envelope cytoplasm mitochondrion biological_process response to toxic substance oxidoreductase activity cellular response to oxidative stress myeloid dendritic cell differentiation negative regulation of apoptotic process oxidation-reduction process uc007tyk.1 uc007tyk.2 uc007tyk.3 uc007tyk.4 
ENSMUST00000022821.8 Dhrs4 ENSMUST00000022821.8 dehydrogenase/reductase 4, transcript variant 1 (from RefSeq NM_001037938.2) D14Ucla2 DHRS4_MOUSE Dhrs4 ENSMUST00000022821.1 ENSMUST00000022821.2 ENSMUST00000022821.3 ENSMUST00000022821.4 ENSMUST00000022821.5 ENSMUST00000022821.6 ENSMUST00000022821.7 G3X8V7 NM_001037938 Q99LB2 Q9EQU4 uc007tym.1 uc007tym.2 uc007tym.3 NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces all-trans-retinal and 9-cis retinal. Reduces 3- ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin. In the reverse reaction, catalyzes the NADP-dependent oxidation of 3alpha- hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds. Reaction=a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH; Xref=Rhea:RHEA:19257, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.184; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:19259; Evidence=; Reaction=3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) = 5beta-pregnan- 3,20-dione + H(+) + NADPH; Xref=Rhea:RHEA:69016, ChEBI:CHEBI:1712, ChEBI:CHEBI:15378, ChEBI:CHEBI:30154, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69017; Evidence=; Reaction=5beta-dihydrotestosterone + H(+) + NADPH = 5beta-androstane- 3alpha,17beta-diol + NADP(+); Xref=Rhea:RHEA:69028, ChEBI:CHEBI:2150, ChEBI:CHEBI:15378, ChEBI:CHEBI:36714, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69029; Evidence=; Reaction=all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH; Xref=Rhea:RHEA:25033, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.300; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:25035; Evidence=; Reaction=H(+) + isatin + NADPH = 3-hydroxyindolin-2-one + NADP(+); Xref=Rhea:RHEA:68608, ChEBI:CHEBI:15378, ChEBI:CHEBI:27539, ChEBI:CHEBI:28536, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68609; Evidence=; Homotetramer. Peroxisome The C-terminus peroxisomal targeting signal tripeptide is important for peroxisomal import. Once in the peroxisome, it is involved in intersubunit interactions. Three specific residues, Phe-177, Leu-180 and Asn-196 are conserved between non-primate mammals whereas the respective residues are serine, phenylalanine and threonine in primates. The two residues at positions 177 and 180 are molecular determinants responsible for the stereoselective reduction of 3-ketosteroids and benzil. The presence of an asparagine at position 196 is important for the maintenance of the quaternary structure resulting in stability at cold temperature and improved catalytic activity toward retinal. Primate DHRS4s display different stereoselectivity and catalytic efficiency in the oxidoreduction of some substrates as compared to other mammal DHRS4s due to a difference in conserved amino acid residues. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Sequence=AAH03484.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB18776.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; 3-keto sterol reductase activity retinal dehydrogenase activity carbonyl reductase (NADPH) activity nucleus mitochondrion peroxisome peroxisomal membrane alcohol metabolic process steroid metabolic process oxidoreductase activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor alcohol dehydrogenase [NAD(P)+] activity cellular ketone metabolic process retinal metabolic process protein tetramerization oxidation-reduction process uc007tym.1 uc007tym.2 uc007tym.3 
ENSMUST00000022826.7 Fitm1 ENSMUST00000022826.7 fat storage-inducing transmembrane protein 1 (from RefSeq NM_026808.1) ENSMUST00000022826.1 ENSMUST00000022826.2 ENSMUST00000022826.3 ENSMUST00000022826.4 ENSMUST00000022826.5 ENSMUST00000022826.6 FITM1_MOUSE Fit1 Fitm1 NM_026808 Q80ZL0 Q8CI63 Q91V79 Q9CTD0 uc007tzc.1 uc007tzc.2 uc007tzc.3 Plays an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:18160536, PubMed:22106267) (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol (PubMed:22106267) (By similarity). Endoplasmic reticulum membrane ulti-pass membrane protein Predominantly expressed in skeletal muscle and at lower levels in the heart (at protein level). In the heart, mRNA expression levels do not correlate well with protein levels, suggesting post-transcriptional regulation in this organ. Knockout mice show no significant differences in heart size or function. Belongs to the FIT family. FIT1 subfamily. Sequence=AAH37188.1; Type=Erroneous initiation; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane phospholipid biosynthetic process positive regulation of sequestering of triglyceride membrane integral component of membrane lipid storage integral component of endoplasmic reticulum membrane lipid particle organization uc007tzc.1 uc007tzc.2 uc007tzc.3 
ENSMUST00000022828.9 Emc9 ENSMUST00000022828.9 ER membrane protein complex subunit 9, transcript variant 1 (from RefSeq NM_033146.2) Cgi112 EMC9_MOUSE ENSMUST00000022828.1 ENSMUST00000022828.2 ENSMUST00000022828.3 ENSMUST00000022828.4 ENSMUST00000022828.5 ENSMUST00000022828.6 ENSMUST00000022828.7 ENSMUST00000022828.8 Fam158a NM_033146 Q9DB76 uc007tze.1 uc007tze.2 uc007tze.3 Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N- exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Component of the ER membrane protein complex (EMC). EMC8 and EMC9 are mutually exclusive subunits of the EMC complex. Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the EMC8/EMC9 family. cytoplasm ER membrane protein complex uc007tze.1 uc007tze.2 uc007tze.3 
ENSMUST00000022830.14 Ripk3 ENSMUST00000022830.14 receptor-interacting serine-threonine kinase 3, transcript variant 1 (from RefSeq NM_019955.2) ENSMUST00000022830.1 ENSMUST00000022830.10 ENSMUST00000022830.11 ENSMUST00000022830.12 ENSMUST00000022830.13 ENSMUST00000022830.2 ENSMUST00000022830.3 ENSMUST00000022830.4 ENSMUST00000022830.5 ENSMUST00000022830.6 ENSMUST00000022830.7 ENSMUST00000022830.8 ENSMUST00000022830.9 G3X8V8 NM_019955 Q3U3Z9 Q8K2Y2 Q9QZL0 RIPK3_MOUSE Rip3 Ripk3 uc007uav.1 uc007uav.2 uc007uav.3 uc007uav.4 Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:27321907, PubMed:27746097, PubMed:27917412, PubMed:28607035, PubMed:32200799, PubMed:32296175). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19590578, PubMed:22423968, PubMed:24012422, PubMed:24019532, PubMed:24557836, PubMed:27746097, PubMed:27819681, PubMed:27819682, PubMed:24095729, PubMed:32200799, PubMed:27321907, PubMed:32296175). Activated RIPK3 forms a necrosis- inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:24813849, PubMed:24813850, PubMed:27321907). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799, PubMed:32296175). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (PubMed:27321907). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (By similarity). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (PubMed:30635240). In response to flavivirus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up- regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (PubMed:30635240). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (PubMed:30635240). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (By similarity). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Activity is stimulated by ZBP1, which senses double-stranded Z-RNA structures (PubMed:32200799, PubMed:32296175). RIPK3-dependent necroptosis is inhibited by RIPK1: RIPK1 prevents the ZBP1-induced activation of RIPK3 via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:24813849, PubMed:24813850, PubMed:24557836, PubMed:27321907, PubMed:27819681, PubMed:27819682, PubMed:32296175). Inhibited by type II inhibitor 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3- b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide (PubMed:32184955). Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necrosis-inducing complex (PubMed:27321907, PubMed:27819681, PubMed:28842570, PubMed:31519887). Interacts with MLKL; the interaction is direct and triggers necroptosis (PubMed:24012422, PubMed:27321907). Interacts with ZBP1 (via RIP homotypic interaction motif); interaction with ZBP1 activates RIPK3, triggering necroptosis (PubMed:19590578, PubMed:22423968, PubMed:27746097, PubMed:27819681, PubMed:27819682, PubMed:28607035, PubMed:32200799). Upon TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity (By similarity). Binds TRAF2 and is recruited to the TNFR-1 signaling complex (By similarity). Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes (By similarity). Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4 (By similarity). Interacts with ARHGEF2 (By similarity). Interacts with PELI1 (via atypical FHA domain); the phosphorylated form at Thr-187 binds preferentially to PELI1 (PubMed:29883609). Interacts with BUB1B, TRAF2 and STUB1 (By similarity). Interacts with CASP6 (By similarity). Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis) (PubMed:34471287). (Microbial infection) Interacts (via RIP homotypic interaction motif) with murid herpesvirus protein RIR1; this interaction disrupts RIP3-RIP1 interactions characteristic of TNF-alpha induced necroptosis, thereby suppressing this death pathway. Q9QZL0; Q61160: Fadd; NbExp=6; IntAct=EBI-2367423, EBI-524415; Q9QZL0; Q9D2Y4: Mlkl; NbExp=3; IntAct=EBI-2367423, EBI-5401970; Q9QZL0; Q60855: Ripk1; NbExp=4; IntAct=EBI-2367423, EBI-529119; Q9QZL0; Q9UER7: DAXX; Xeno; NbExp=2; IntAct=EBI-2367423, EBI-77321; Cytoplasm, cytosol cleus te=Mainly cytoplasmic (PubMed:32200799, PubMed:32296175). Present in the nucleus in response to influenza A virus (IAV) infection (PubMed:32200799). Expressed in embryo and in adult spleen, liver, testis, heart, brain and lung. The RIP homotypic interaction motif (RHIM) mediates interaction with the RHIM motif of RIPK1. Both motifs form a hetero-amyloid serpentine fold, stabilized by hydrophobic packing and featuring an unusual Cys-Ser ladder of alternating Ser (from RIPK1) and Cys (from RIPK3). RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (By similarity). Autophosphorylated following interaction with ZBP1 (PubMed:27819681). Phosphorylation of Ser-204 plays a role in the necroptotic function of RIPK3 (By similarity). Autophosphorylates at Thr-231 and Ser-232 following activation by ZBP1: phosphorylation at these sites is a hallmark of necroptosis and is required for binding MLKL (PubMed:23612963, PubMed:27819682). Phosphorylation at Thr-187 is important for its kinase activity, interaction with PELI1 and for its ability to mediate TNF-induced necroptosis (By similarity). Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. Ubiquitinated by STUB1 leading to its subsequent proteasome-dependent degradation. No visible phenotype in normal conditions; mice are viable and indistinguishable from wild-type mice (PubMed:14749364, PubMed:24557836). Mice are resistant to TNF-induced hypothermia (PubMed:24557836). Mice are more susceptible to influenza A virus (IAV) infection than wild-type mice: at a modestly lethal dose of IAV, mice display significantly increased rates of mortality, probably caused by a failure to eliminate infected cells and limit virus spread in pulmonary tissue (PubMed:27321907, PubMed:32200799). Perinatal lethality observed in Ripk1 knockout mice is rescued in knockout mice lacking both Ripk1 and Ripk3; mice however die the first days of postnatal life (PubMed:24813849, PubMed:24813850, PubMed:27819681, PubMed:27819682). Only mice lacking Ripk1, Ripk3 and Casp8 survive past weaning and rescue lethality caused by the absence of Ripk1 (PubMed:24813849, PubMed:24813850). Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. nucleotide binding regulation of T cell mediated cytotoxicity regulation of adaptive immune response protein kinase activity protein serine/threonine kinase activity NF-kappaB-inducing kinase activity protein binding ATP binding cytoplasm mitochondrion cytosol plasma membrane protein phosphorylation I-kappaB kinase/NF-kappaB signaling positive regulation of phosphatase activity positive regulation of necrotic cell death programmed cell death membrane viral process kinase activity phosphorylation transferase activity activation of protein kinase activity regulation of interferon-gamma production T cell differentiation in thymus NIK/NF-kappaB signaling identical protein binding T cell homeostasis macromolecular complex binding regulation of activated T cell proliferation protein autophosphorylation lymph node development spleen development thymus development positive regulation of NF-kappaB transcription factor activity protein homooligomerization protein heterooligomerization positive regulation of ligase activity positive regulation of oxidoreductase activity positive regulation of necroptotic process regulation of activation-induced cell death of T cells necroptotic process cellular response to hydrogen peroxide programmed necrotic cell death amyloid fibril formation regulation of reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation positive regulation of intrinsic apoptotic signaling pathway uc007uav.1 uc007uav.2 uc007uav.3 uc007uav.4 
ENSMUST00000022831.5 Khnyn ENSMUST00000022831.5 KH and NYN domain containing, transcript variant 1 (from RefSeq NM_027143.3) ENSMUST00000022831.1 ENSMUST00000022831.2 ENSMUST00000022831.3 ENSMUST00000022831.4 KHNYN_MOUSE Kiaa0323 NM_027143 Q14B94 Q80U38 Q8BGJ6 Q8C082 uc007ubb.1 uc007ubb.2 uc007ubb.3 This gene encodes a protein with a C-terminal RNA modifying domain that belongs to a family of ribonucleases typified by eukaryotic Nedd4-binding protein1 and the bacterial YacP-like nucleases (NYN). The NYN domain shares a common protein fold with two other groups of nucleases, the PilT N-terminal nuclease and FLAP nuclease superfamilies. In addition to the NYN domain, the protein encoded by this gene also contains an N-terminal K homology RNA-binding domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]. Belongs to the N4BP1 family. Sequence=BAC27665.1; Type=Frameshift; Evidence=; Sequence=BAC65529.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc007ubb.1 uc007ubb.2 uc007ubb.3 
ENSMUST00000022836.6 Mcpt1 ENSMUST00000022836.6 mast cell protease 1 (from RefSeq NM_008570.1) ENSMUST00000022836.1 ENSMUST00000022836.2 ENSMUST00000022836.3 ENSMUST00000022836.4 ENSMUST00000022836.5 Mcpt1 NM_008570 Q496V0 Q496V0_MOUSE uc007ubi.1 uc007ubi.2 uc007ubi.3 serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc007ubi.1 uc007ubi.2 uc007ubi.3 
ENSMUST00000022842.16 Cct5 ENSMUST00000022842.16 chaperonin containing TCP1 subunit 5, transcript variant 1 (from RefSeq NM_007637.3) Ccte ENSMUST00000022842.1 ENSMUST00000022842.10 ENSMUST00000022842.11 ENSMUST00000022842.12 ENSMUST00000022842.13 ENSMUST00000022842.14 ENSMUST00000022842.15 ENSMUST00000022842.2 ENSMUST00000022842.3 ENSMUST00000022842.4 ENSMUST00000022842.5 ENSMUST00000022842.6 ENSMUST00000022842.7 ENSMUST00000022842.8 ENSMUST00000022842.9 Kiaa0098 NM_007637 P80316 Q3TIE0 Q3U530 Q3UCU4 Q3UJK9 Q3UWA9 Q542K3 Q6ZQJ1 TCPE_MOUSE uc007vkj.1 uc007vkj.2 uc007vkj.3 Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity). Interacts with DNAAF4 (PubMed:23872636). Interacts with DLEC1 (By similarity). Interacts with SPMAP2 (PubMed:10747865). P80316; Q9JMB1: Spmap2; NbExp=2; IntAct=EBI-772379, EBI-1390549; Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome The N-terminus is blocked. Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation. Belongs to the TCP-1 chaperonin family. Sequence=BAC97866.1; Type=Erroneous initiation; Evidence=; nucleotide binding mRNA 3'-UTR binding protein binding ATP binding nucleolus cytoplasm centrosome microtubule organizing center cytosol chaperonin-containing T-complex cytoskeleton microtubule protein folding binding of sperm to zona pellucida response to virus G-protein beta-subunit binding positive regulation of telomere maintenance via telomerase myelin sheath cell body mRNA 5'-UTR binding beta-tubulin binding protein stabilization unfolded protein binding toxin transport positive regulation of establishment of protein localization to telomere uc007vkj.1 uc007vkj.2 uc007vkj.3 
ENSMUST00000022849.7 Tars1 ENSMUST00000022849.7 threonyl-tRNA synthetase 1 (from RefSeq NM_033074.3) ENSMUST00000022849.1 ENSMUST00000022849.2 ENSMUST00000022849.3 ENSMUST00000022849.4 ENSMUST00000022849.5 ENSMUST00000022849.6 NM_033074 Q3TL42 Q7TMQ2 Q8BMI6 Q9CX03 Q9D0R2 SYTC_MOUSE Tars uc007vhc.1 uc007vhc.2 uc007vhc.3 Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post- transfer stage. Reaction=ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L- threonyl-tRNA(Thr); Xref=Rhea:RHEA:24624, Rhea:RHEA-COMP:9670, Rhea:RHEA-COMP:9704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57926, ChEBI:CHEBI:78442, ChEBI:CHEBI:78534, ChEBI:CHEBI:456215; EC=6.1.1.3; Evidence=; Kinetic parameters: KM=0.74 uM for tRNA(Thr) ; KM=0.30 mM for L-threonine ; Homodimer. Cytoplasm ISGylated. Belongs to the class-II aminoacyl-tRNA synthetase family. nucleotide binding aminoacyl-tRNA ligase activity threonine-tRNA ligase activity ATP binding cytoplasm cytosol translation tRNA aminoacylation for protein translation threonyl-tRNA aminoacylation actin cytoskeleton ligase activity tRNA aminoacylation uc007vhc.1 uc007vhc.2 uc007vhc.3 
ENSMUST00000022853.15 C1qtnf3 ENSMUST00000022853.15 C1q and tumor necrosis factor related protein 3, transcript variant 2 (from RefSeq NM_030888.4) C1QT3_MOUSE Cors26 Ctrp3 ENSMUST00000022853.1 ENSMUST00000022853.10 ENSMUST00000022853.11 ENSMUST00000022853.12 ENSMUST00000022853.13 ENSMUST00000022853.14 ENSMUST00000022853.2 ENSMUST00000022853.3 ENSMUST00000022853.4 ENSMUST00000022853.5 ENSMUST00000022853.6 ENSMUST00000022853.7 ENSMUST00000022853.8 ENSMUST00000022853.9 NM_030888 Q9ES30 uc007vgu.1 uc007vgu.2 uc007vgu.3 uc007vgu.4 Secreted extracellular region collagen trimer extracellular space cell negative regulation of gene expression macromolecular complex cellular triglyceride homeostasis glucose homeostasis identical protein binding negative regulation of gluconeogenesis positive regulation of cytokine secretion negative regulation of inflammatory response positive regulation of protein kinase B signaling positive regulation of adiponectin secretion protein trimerization positive regulation of ERK1 and ERK2 cascade negative regulation of monocyte chemotactic protein-1 production negative regulation of interleukin-6 secretion negative regulation of NIK/NF-kappaB signaling uc007vgu.1 uc007vgu.2 uc007vgu.3 uc007vgu.4 
ENSMUST00000022855.12 Brix1 ENSMUST00000022855.12 BRX1, biogenesis of ribosomes (from RefSeq NM_026396.3) BRX1_MOUSE Brix Bxdc2 ENSMUST00000022855.1 ENSMUST00000022855.10 ENSMUST00000022855.11 ENSMUST00000022855.2 ENSMUST00000022855.3 ENSMUST00000022855.4 ENSMUST00000022855.5 ENSMUST00000022855.6 ENSMUST00000022855.7 ENSMUST00000022855.8 ENSMUST00000022855.9 NM_026396 Q3THD3 Q91YS6 Q9DCA5 uc007vgg.1 uc007vgg.2 uc007vgg.3 Required for biogenesis of the 60S ribosomal subunit. Nucleus, nucleolus Belongs to the BRX1 family. Sequence=AAH14832.1; Type=Erroneous initiation; Evidence=; Sequence=BAB22497.1; Type=Erroneous initiation; Evidence=; ribosomal large subunit assembly nucleus nucleolus ribosome biogenesis uc007vgg.1 uc007vgg.2 uc007vgg.3 
ENSMUST00000022856.15 Rad1 ENSMUST00000022856.15 RAD1 checkpoint DNA exonuclease, transcript variant 1 (from RefSeq NM_011232.4) ENSMUST00000022856.1 ENSMUST00000022856.10 ENSMUST00000022856.11 ENSMUST00000022856.12 ENSMUST00000022856.13 ENSMUST00000022856.14 ENSMUST00000022856.2 ENSMUST00000022856.3 ENSMUST00000022856.4 ENSMUST00000022856.5 ENSMUST00000022856.6 ENSMUST00000022856.7 ENSMUST00000022856.8 ENSMUST00000022856.9 NM_011232 O70452 O88391 Q3TGU1 Q3UG66 Q9QWZ1 Q9QWZ3 RAD1_MOUSE Rec1 uc007vgh.1 uc007vgh.2 uc007vgh.3 uc007vgh.4 Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the RAD17-RFC complex. RAD1 interacts with POLB, FEN1, HUS1, HUS1B, RAD9A and RAD9B. Interacts with DNAJC7. Interacts with RHNO1; interaction is direct. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QWZ1-1; Sequence=Displayed; Name=2; IsoId=Q9QWZ1-2; Sequence=VSP_017337; Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level). Expressed in brain, testis, kidney, heart, liver and lung. Belongs to the rad1 family. DNA damage checkpoint nuclease activity exonuclease activity nucleus nucleoplasm chromosome DNA repair cellular response to DNA damage stimulus 3'-5' exonuclease activity exodeoxyribonuclease III activity hydrolase activity checkpoint clamp complex intracellular membrane-bounded organelle meiotic recombination checkpoint cellular response to ionizing radiation nucleic acid phosphodiester bond hydrolysis uc007vgh.1 uc007vgh.2 uc007vgh.3 uc007vgh.4 
ENSMUST00000022857.14 Ttc23l ENSMUST00000022857.14 tetratricopeptide repeat domain 23-like, transcript variant 1 (from RefSeq NM_029430.1) A3KMM7 A6H6E9 ENSMUST00000022857.1 ENSMUST00000022857.10 ENSMUST00000022857.11 ENSMUST00000022857.12 ENSMUST00000022857.13 ENSMUST00000022857.2 ENSMUST00000022857.3 ENSMUST00000022857.4 ENSMUST00000022857.5 ENSMUST00000022857.6 ENSMUST00000022857.7 ENSMUST00000022857.8 ENSMUST00000022857.9 NM_029430 Q9D5Q3 TT23L_MOUSE uc007vgj.1 uc007vgj.2 uc007vgj.3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Midbody Note=Exhibits dynamic subcellular localization during the cell cycle. In prophase cells, detected on split centrosomes. Translocates to the mitotic spindles during metaphase and early anaphase, then to the midbody and cleavage furrow in late anaphase. Sequence=AAI32385.1; Type=Erroneous initiation; Evidence=; Sequence=BAB29682.1; Type=Erroneous initiation; Evidence=; cellular_component cytoplasm microtubule organizing center spindle cytoskeleton biological_process midbody uc007vgj.1 uc007vgj.2 uc007vgj.3 
ENSMUST00000022861.9 Ugt3a2 ENSMUST00000022861.9 UDP glycosyltransferases 3 family, polypeptide A1 (from RefSeq NM_207216.2) ENSMUST00000022861.1 ENSMUST00000022861.2 ENSMUST00000022861.3 ENSMUST00000022861.4 ENSMUST00000022861.5 ENSMUST00000022861.6 ENSMUST00000022861.7 ENSMUST00000022861.8 NM_207216 Q3UP75 Q8R0Y5 UD3A1_MOUSE Ugt3a1 uc007vfk.1 uc007vfk.2 uc007vfk.3 uc007vfk.4 uc007vfk.5 UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Membrane ; Single-pass type I membrane protein Highly expressed in kidney, while it is expressed at low levels in liver. Not detected in other tissues examined. Belongs to the UDP-glycosyltransferase family. UDP-glycosyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups intracellular membrane-bounded organelle UDP-N-acetylglucosamine transferase complex cellular response to genistein uc007vfk.1 uc007vfk.2 uc007vfk.3 uc007vfk.4 uc007vfk.5 
ENSMUST00000022865.17 Mtdh ENSMUST00000022865.17 metadherin, transcript variant 3 (from RefSeq NM_026002.5) B2RSG8 ENSMUST00000022865.1 ENSMUST00000022865.10 ENSMUST00000022865.11 ENSMUST00000022865.12 ENSMUST00000022865.13 ENSMUST00000022865.14 ENSMUST00000022865.15 ENSMUST00000022865.16 ENSMUST00000022865.2 ENSMUST00000022865.3 ENSMUST00000022865.4 ENSMUST00000022865.5 ENSMUST00000022865.6 ENSMUST00000022865.7 ENSMUST00000022865.8 ENSMUST00000022865.9 LYRIC_MOUSE Lyric NM_026002 Q05CM0 Q3U9F8 Q3UAQ8 Q80WJ7 Q8BN67 Q8CBT9 Q8CDL0 Q8CGI7 Q9D052 uc007vlh.1 uc007vlh.2 uc007vlh.3 Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity). Interacts with BCCIP, CREBBP/CBP and RELA/p65. Q80WJ7; Q78PY7: Snd1; NbExp=4; IntAct=EBI-774530, EBI-529864; Endoplasmic reticulum membrane ; Single-pass membrane protein Nucleus membrane ; Single-pass membrane protein Cell junction, tight junction Nucleus, nucleolus Cytoplasm, perinuclear region Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain. TNF- alpha causes translocation from the cytoplasm to the nucleus (By similarity). In the mammary gland, expressed at the apical surface of epithelial cells lining ducts, as well as in the mammary fat pad. Not detected in the spleen, kidney, lung, or skin; minute amounts seen in the liver. Expressed in Purkinje neurons in the early postnatal and adult cerebellum. Overexpressed in mammary tumors (at protein level). Was originally thought to be a type II membrane protein but this is inconsistent with the results of multiple phosphorylation studies because this topology would locate the phosphorylation sites in the lumen or extracellularly rather than in the cytoplasm. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding fibrillar center transcription coactivator activity double-stranded RNA binding protein binding nucleus nucleolus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane bicellular tight junction positive regulation of autophagy membrane integral component of membrane apical plasma membrane nuclear body cell junction lipopolysaccharide-mediated signaling pathway nuclear membrane negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of angiogenesis intercellular canaliculus perinuclear region of cytoplasm NF-kappaB binding positive regulation of NF-kappaB transcription factor activity positive regulation of protein kinase B signaling bicellular tight junction assembly positive regulation of nucleic acid-templated transcription uc007vlh.1 uc007vlh.2 uc007vlh.3 
ENSMUST00000022867.5 Laptm4b ENSMUST00000022867.5 lysosomal-associated protein transmembrane 4B (from RefSeq NM_033521.4) ENSMUST00000022867.1 ENSMUST00000022867.2 ENSMUST00000022867.3 ENSMUST00000022867.4 LAP4B_MOUSE Laptm4b NM_033521 Q91XQ6 uc007vlj.1 uc007vlj.2 uc007vlj.3 Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. Homooligomer; upon reaching the lysosomes. Interacts with MCOLN1. Interacts with NEDD4; may play a role in the lysosomal sorting of LAPTM4B; enhances HGS association with NEDD4; mediates inhibition of EGFR degradation. Interacts with PIP5K1C; promotes SNX5 association with LAPTM4B; kinase activity of PIP5K1C is required; interaction is regulated by phosphatidylinositol 4,5-bisphosphate generated by PIP5K1C. Interacts with HGS; promotes HGS ubiquitination. Interacts with SNX5. Interacts with SLC3A2 and SLC7A5; recruits SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation. Interacts with LRRC32; decreases TGFB1 production in regulatory T cells. Interacts with BECN1; competes with EGFR for LAPTM4B binding; regulates EGFR activity. Interacts with EGFR; positively correlates with EGFR activation. Endomembrane system ; Multi-pass membrane protein Late endosome membrane Cell membrane Cell projection Lysosome membrane Endosome membrane Endosome, multivesicular body membrane Endosome, multivesicular body lumen Undergoes proteolytic cleavage following delivery to the lysosomes. Ubiquitinated by NEDD4. Belongs to the LAPTM4/LAPTM5 transporter family. lysosome lysosomal membrane endosome early endosome plasma membrane endosome organization endosome membrane endomembrane system membrane integral component of membrane kinase binding ubiquitin protein ligase binding late endosome membrane endosome transport via multivesicular body sorting pathway multivesicular body membrane negative regulation of transforming growth factor beta1 production cell projection ceramide binding regulation of lysosomal membrane permeability multivesicular body, internal vesicle phosphatidylinositol bisphosphate binding negative regulation of lysosomal protein catabolic process regulation of lysosome organization uc007vlj.1 uc007vlj.2 uc007vlj.3 
ENSMUST00000022871.7 Sdc2 ENSMUST00000022871.7 syndecan 2 (from RefSeq NM_008304.2) ENSMUST00000022871.1 ENSMUST00000022871.2 ENSMUST00000022871.3 ENSMUST00000022871.4 ENSMUST00000022871.5 ENSMUST00000022871.6 Hspg1 NM_008304 P43407 SDC2_MOUSE Synd2 uc007vkx.1 uc007vkx.2 uc007vkx.3 Cell surface proteoglycan which regulates dendritic arbor morphogenesis. Interacts (via cytoplasmic domain) with SARM1 (PubMed:21555464). Forms a complex with SDCBP and PDCD6IP (By similarity). P43407; Q15113: PCOLCE; Xeno; NbExp=4; IntAct=EBI-11578890, EBI-8869614; Membrane; Single-pass type I membrane protein. Preferential expression in cells of mesenchymal origin. O-glycosylated; contains both heparan sulfate and chondroitin sulfate. Phosphorylated on serine residues. Belongs to the syndecan proteoglycan family. protein binding Golgi lumen nervous system development cell surface membrane integral component of membrane cell migration cell differentiation PDZ domain binding identical protein binding neuronal cell body synapse dendrite morphogenesis regulation of dendrite morphogenesis uc007vkx.1 uc007vkx.2 uc007vkx.3 
ENSMUST00000022875.7 Ank ENSMUST00000022875.7 progressive ankylosis (from RefSeq NM_020332.4) ANKH_MOUSE Ankh ENSMUST00000022875.1 ENSMUST00000022875.2 ENSMUST00000022875.3 ENSMUST00000022875.4 ENSMUST00000022875.5 ENSMUST00000022875.6 NM_020332 O35138 O35139 Q9JHZ2 uc007vjo.1 uc007vjo.2 uc007vjo.3 uc007vjo.4 Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1. Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength. The transport mechanism remains to be elucidated. Reaction=ATP(in) = ATP(out); Xref=Rhea:RHEA:75687, ChEBI:CHEBI:30616; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75688; Evidence=; Reaction=citrate(in) = citrate(out); Xref=Rhea:RHEA:33183, ChEBI:CHEBI:16947; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33184; Evidence=; Cell membrane ; Multi-pass membrane protein Expressed in heart, brain, liver, spleen, lung, muscle, and kidney of adult animals. Strongly expressed in the developing articular cartilage of joints in the shoulder, elbow, wrist, and digits of the embryo. Note=Defects in Ankh are the cause of a generalized, progressive form of arthritis. In ank mice hydroxyapatite crystals develop in articular surfaces and synovial fluid leading to joint space narrowing, cartilage erosion, and formation of bony outgrowths or osteophytes that cause fusion and joint immobility and destruction. Mutant mice develop early-onset osteopenia in long bones associated with diminished bone strength. They show widespread calcification of soft connective tissues due to almost absence of PPi in plasma. Belongs to the ANKH family. inorganic phosphate transmembrane transporter activity plasma membrane integral component of plasma membrane phosphate ion transport phosphate ion transmembrane transporter activity membrane integral component of membrane regulation of bone mineralization inorganic diphosphate transmembrane transporter activity inorganic diphosphate transport phosphate ion transmembrane transport uc007vjo.1 uc007vjo.2 uc007vjo.3 uc007vjo.4 
ENSMUST00000022890.10 Rnf19a ENSMUST00000022890.10 ring finger protein 19A, transcript variant 1 (from RefSeq NM_013923.2) ENSMUST00000022890.1 ENSMUST00000022890.2 ENSMUST00000022890.3 ENSMUST00000022890.4 ENSMUST00000022890.5 ENSMUST00000022890.6 ENSMUST00000022890.7 ENSMUST00000022890.8 ENSMUST00000022890.9 Geg-154 NM_013923 P50636 Q3UGT2 Q9QUJ5 RN19A_MOUSE Rnf19 Xybp uc007vmq.1 uc007vmq.2 uc007vmq.3 E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence=; Protein modification; protein ubiquitination. Interacts with UBE2L3 and UBE2L6. Also interacts with transcription factor Sp1. Interacts with SNCAIP and CASR (By similarity). Interacts with VCP. P50636; Q9Z0P7: Sufu; NbExp=3; IntAct=EBI-3508340, EBI-3508336; Membrane ; Multi-pass membrane protein Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Expressed primarily in the XY body of pachytene spermatocytes and in the centrosome of somatic and germ cells in all phases of the cell cycle. Preferentially expressed in both sexes during gametogenesis. Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT- type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain. Belongs to the RBR family. RNF19 subfamily. Sequence=CAA50643.1; Type=Frameshift; Evidence=; ubiquitin ligase complex protein polyubiquitination ubiquitin-protein transferase activity protein binding cytoplasm microtubule organizing center cytoskeleton ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination transferase activity ubiquitin conjugating enzyme binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity postsynapse glutamatergic synapse regulation of protein catabolic process at postsynapse, modulating synaptic transmission uc007vmq.1 uc007vmq.2 uc007vmq.3 
ENSMUST00000022894.14 Ywhaz ENSMUST00000022894.14 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, transcript variant 1 (from RefSeq NM_011740.3) 1433Z_MOUSE ENSMUST00000022894.1 ENSMUST00000022894.10 ENSMUST00000022894.11 ENSMUST00000022894.12 ENSMUST00000022894.13 ENSMUST00000022894.2 ENSMUST00000022894.3 ENSMUST00000022894.4 ENSMUST00000022894.5 ENSMUST00000022894.6 ENSMUST00000022894.7 ENSMUST00000022894.8 ENSMUST00000022894.9 NM_011740 P35215 P63101 P70197 P97286 Q3TSF1 Q5EBQ1 uc007vmz.1 uc007vmz.2 uc007vmz.3 uc007vmz.4 uc007vmz.5 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). Homodimer. Heterodimerizes with YWHAE (By similarity). Homo- and heterodimerization is inhibited by phosphorylation on Ser-58 (By similarity). Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with CDK16 and with WEE1 (C-terminal). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with BSPRY. Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation (By similarity). It may also prevent thiol-dependent inactivation (By similarity). Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization (By similarity). Interacts with GAB2 (By similarity). Interacts with SAMSN1. Interacts with BCL2L11 and TLK2. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways (PubMed:22701344). Interacts with SLITRK1 (By similarity). Interacts with AK5, LDB1, MADD, PDE1A and SMARCB1 (By similarity). Interacts with ARHGEF7 and GIT1 (PubMed:16959763). Interacts with MEFV (By similarity). Interacts with ADAM22 (via C-terminus) (By similarity). P63101; Q5S006: Lrrk2; NbExp=5; IntAct=EBI-354751, EBI-2693710; P63101; Q9QWV4: Mlf1; NbExp=3; IntAct=EBI-354751, EBI-354765; P63101; O43524: FOXO3; Xeno; NbExp=2; IntAct=EBI-354751, EBI-1644164; P63101; Q92945: KHSRP; Xeno; NbExp=2; IntAct=EBI-354751, EBI-1049099; Cytoplasm Melanosome Note=Located to stage I to stage IV melanosomes. The delta, brain-specific form differs from the zeta form in being phosphorylated (Probable). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria (By similarity). Phosphorylation on Thr-232; inhibits binding of RAF1 (By similarity). Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (PubMed:9705322). Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53 (By similarity). Belongs to the 14-3-3 family. histamine secretion by mast cell protein binding nucleus cytoplasm mitochondrion cytosol protein targeting protein targeting to mitochondrion synaptic target recognition transcription factor binding regulation of cell death postsynaptic density protein kinase binding protein domain specific binding cell leading edge ubiquitin protein ligase binding macromolecular complex melanosome response to drug mast cell granule identical protein binding ion channel binding macromolecular complex binding perinuclear region of cytoplasm establishment of Golgi localization regulation of synapse maturation Golgi reassembly glutamatergic synapse uc007vmz.1 uc007vmz.2 uc007vmz.3 uc007vmz.4 uc007vmz.5 
ENSMUST00000022895.15 Grhl2 ENSMUST00000022895.15 grainyhead like transcription factor 2 (from RefSeq NM_026496.4) Bom ENSMUST00000022895.1 ENSMUST00000022895.10 ENSMUST00000022895.11 ENSMUST00000022895.12 ENSMUST00000022895.13 ENSMUST00000022895.14 ENSMUST00000022895.2 ENSMUST00000022895.3 ENSMUST00000022895.4 ENSMUST00000022895.5 ENSMUST00000022895.6 ENSMUST00000022895.7 ENSMUST00000022895.8 ENSMUST00000022895.9 GRHL2_MOUSE NM_026496 Q80UZ5 Q8K5C0 Tcfcp2l3 uc007vne.1 uc007vne.2 uc007vne.3 uc007vne.4 Transcription factor playing an important role in primary neurulation and in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:22696678). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (PubMed:20654612). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (PubMed:22696678). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia (PubMed:20978075). Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events such as eyelid fusion and epidermal wound repair (PubMed:21081122). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (PubMed:22955271). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity. In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (By similarity). Homodimer, also forms heterodimers with GRHL1 or GRHL3. Nucleus mbrane Note=detected at cell-cell contact areas. At 14.5 dpc expressed in lung, esophagus, skin and kidney. At 9.5 dpc expressed in foregut and surface ectoderm but not in the neural tube. At 9.5 dpc and 15.5 dpc, detected in the lung epithelium and in branchiolar and alveolar epithelial cells at 18.5 dpc and adult. Expressed in otocyst at 11.5 dpc, prominent in epithelial derivatives of the otic placode in the vestibule and cochlear duct at 18.5 dpc. At postnatal day 5, epithelial cells of the cochlear duct, which surround the endolymph-containing scala media, continued to express low levels, while little or no expression was seen in the mesenchyme-derived cells lining the scala tympani and scala vestibuli. Detected in cholangiocytes in postnatal day 1 and postnatal day 8 livers. Mutant embryos show an epithelial and anterior and posterior neural tube defects leading to death at around 11.5 dpc (PubMed:20654612, PubMed:20978075). They exhibit a fully penetrant split-face malformation, associated with cranioschisis. Closure of the remainder of the neural tube ocrurred normally with the exception of the posterior neuropore. The dorso-lateral hinge points fail to form and closure do not proceed beyond this point (PubMed:20654612). GRHL genes (GRHL1, GRHL2 and GRHL3) show a paradoxal lack of redundancy despite their extensive sequence identity in the DNA-binding and protein dimerization domains and the fact that the core consensus DNA binding sites are identical. They have related but remarkably different functions during embryogenesis because of their differential spatiotemporal expression patterns during development. Belongs to the grh/CP2 family. Grainyhead subfamily. intronic transcription regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development neural tube closure cardiac ventricle morphogenesis epithelial cell morphogenesis DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cell-cell junction regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell adhesion brain development cell proliferation epidermis development regulation of gene expression membrane neural tube development respiratory tube development chromatin DNA binding cell junction assembly multicellular organism growth embryonic digit morphogenesis camera-type eye development sequence-specific DNA binding regulation of DNA methylation negative regulation of keratinocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic organ development embryonic cranial skeleton morphogenesis positive regulation of telomerase activity face development lung lobe morphogenesis lung epithelial cell differentiation epithelial cell morphogenesis involved in placental branching anterior neural tube closure bicellular tight junction assembly epithelium migration uc007vne.1 uc007vne.2 uc007vne.3 uc007vne.4 
ENSMUST00000022901.16 Rrm2b ENSMUST00000022901.16 ribonucleotide reductase M2 B (TP53 inducible), transcript variant 11 (from RefSeq NR_184224.1) ENSMUST00000022901.1 ENSMUST00000022901.10 ENSMUST00000022901.11 ENSMUST00000022901.12 ENSMUST00000022901.13 ENSMUST00000022901.14 ENSMUST00000022901.15 ENSMUST00000022901.2 ENSMUST00000022901.3 ENSMUST00000022901.4 ENSMUST00000022901.5 ENSMUST00000022901.6 ENSMUST00000022901.7 ENSMUST00000022901.8 ENSMUST00000022901.9 NR_184224 P53r2 Q6PEE3 RIR2B_MOUSE uc007vnl.1 uc007vnl.2 uc007vnl.3 uc007vnl.4 Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. Reaction=[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'- diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'- diphosphate; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57930, ChEBI:CHEBI:73316; EC=1.17.4.1; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Note=Binds 2 iron ions per subunit. ; Heterotetramer with large (RRM1) subunit. Interacts with p53/TP53. Interacts with RRM1 in response to DNA damage (By similarity). Cytoplasm Nucleus Note=Translocates from cytoplasm to nucleus in response to DNA damage. Mice develop normally until they are weaned but from then on exhibit growth retardation and early mortality. Pathological examination indicates that multiple organs fail and that they die from severe renal failure by the age of 14 weeks. Belongs to the ribonucleoside diphosphate reductase small chain family. kidney development renal system process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor nucleus nucleoplasm cytoplasm mitochondrion cytosol ribonucleoside-diphosphate reductase complex DNA replication mitochondrial DNA replication DNA repair cellular response to DNA damage stimulus response to oxidative stress deoxyribonucleoside triphosphate metabolic process deoxyribonucleotide biosynthetic process response to amine oxidoreductase activity metal ion binding oxidation-reduction process negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator uc007vnl.1 uc007vnl.2 uc007vnl.3 uc007vnl.4 
ENSMUST00000022904.8 Atp6v1c1 ENSMUST00000022904.8 ATPase, H+ transporting, lysosomal V1 subunit C1 (from RefSeq NM_025494.3) Atp6c Atp6c1 ENSMUST00000022904.1 ENSMUST00000022904.2 ENSMUST00000022904.3 ENSMUST00000022904.4 ENSMUST00000022904.5 ENSMUST00000022904.6 ENSMUST00000022904.7 NM_025494 Q91Z42 Q9Z1G3 VATC1_MOUSE Vatc uc007vnv.1 uc007vnv.2 uc007vnv.3 uc007vnv.4 Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein Ubiquitous. Abundant in brain, liver, kidney and testis. Belongs to the V-ATPase C subunit family. vacuolar proton-transporting V-type ATPase, V1 domain cytoplasm plasma membrane ion transport hydrogen-exporting ATPase activity, phosphorylative mechanism hydrogen ion transmembrane transporter activity cytoplasmic vesicle proton-transporting V-type ATPase, V1 domain apical part of cell proton-transporting ATPase activity, rotational mechanism hydrogen ion transmembrane transport uc007vnv.1 uc007vnv.2 uc007vnv.3 uc007vnv.4 
ENSMUST00000022908.10 Slc25a32 ENSMUST00000022908.10 solute carrier family 25, member 32 (from RefSeq NM_172402.3) ENSMUST00000022908.1 ENSMUST00000022908.2 ENSMUST00000022908.3 ENSMUST00000022908.4 ENSMUST00000022908.5 ENSMUST00000022908.6 ENSMUST00000022908.7 ENSMUST00000022908.8 ENSMUST00000022908.9 Mftc NM_172402 Q3TCM5 Q8BMG8 S2532_MOUSE Slc25a32 uc007vob.1 uc007vob.2 uc007vob.3 uc007vob.4 Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis. Reaction=FAD(in) = FAD(out); Xref=Rhea:RHEA:76535, ChEBI:CHEBI:57692; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Embryonic lethal (PubMed:29666258, PubMed:35727412). At 11.5 dpc, the majority of mutant embryos show neural tube defects with exencephaly or craniorachischisis associated with multiple acyl-CoA dehydrogenase deficiency. Neural tube defects can be prevented by formate supplementation in early embryogenesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. Initially postulated to function as a folate transporter based on complementation evidence, but it was latter shown that it rather function as a FAD transporter indirectly affecting folate-mediated one- carbon metabolism in mitochondria. mitochondrion mitochondrial inner membrane glycine metabolic process folic acid transporter activity FAD transmembrane transporter activity folic acid transport membrane integral component of membrane FAD transmembrane transport uc007vob.1 uc007vob.2 uc007vob.3 uc007vob.4 
ENSMUST00000022909.10 Dcaf13 ENSMUST00000022909.10 DDB1 and CUL4 associated factor 13, transcript variant 1 (from RefSeq NM_198606.3) DCA13_MOUSE E9QPL0 ENSMUST00000022909.1 ENSMUST00000022909.2 ENSMUST00000022909.3 ENSMUST00000022909.4 ENSMUST00000022909.5 ENSMUST00000022909.6 ENSMUST00000022909.7 ENSMUST00000022909.8 ENSMUST00000022909.9 Gm83 NM_198606 Q6PAC3 Wdsof1 uc007voc.1 uc007voc.2 uc007voc.3 uc007voc.4 uc007voc.5 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome (By similarity). Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition (PubMed:30283081). Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that plays a key role in embryo preimplantation and is required for normal meiotic cycle progression in oocytes (PubMed:30111536, PubMed:31492966). Acts as a maternal factor that regulates oocyte and zygotic chromatin tightness during maternal to zygotic transition (PubMed:31000741). Also involved in the transformation of the endometrium into the decidua, known as decidualization, providing a solid foundation for implantation of blastocysts (PubMed:35932979). Recognizes the histone methyltransferases SUV39H1 and SUV39H2 and directs them to polyubiquitination and proteasomal degradation, which facilitates the H3K9me3 removal and early zygotic gene expression, essential steps for progressive genome reprogramming and the establishment of pluripotency during preimplantation embryonic development (PubMed:30111536). Supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting the polyubiquitination and degradation of PTEN, a lipid phosphatase that inhibits PI3K pathway as well as oocyte growth and maturation (PubMed:31492966). Targets PMP22 for polyubiquitination and proteasomal degradation (PubMed:35178836). Protein modification; protein ubiquitination. Component of the DCX(DCAF13) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1, DCAF13 and RBX1. Interacts (via WD40 domain) with DDB1 (PubMed:30111536, PubMed:31492966, PubMed:35178836). Interacts with ESR1 and LATS1 (By similarity). Nucleus, nucleolus te=In the nucleolus, localizes predominantly in the granular component, but also detected in the fibrillar center and dense fibrillar component. Uniformly distributed in trophectoderm cells and inner cells mass in blastocyst embryos (PubMed:30111536). Expressed in oocytes as early as the primordial follicle stage (PubMed:30283081). Endometrial expression increases during decidualization and is highly expressed in decidua (PubMed:35932979). In embryo, expressed as early as the four-cell stage and continue to accumulate in morulae and blastocysts (at protein level) (PubMed:30111536). Expressed in growing oocytes with the nonsurrounded nucleolus configuration, reaches a peak in oocytes within pre-antral and early antral follicles and nearly disappears in the fully grown oocyte with the surrounded nucleolus configuration (PubMed:30283081). Knockout embryos are arrested at the eight- to sixteen-cell stage before compaction causing preimplantation-stage mortality (PubMed:30111536). Mutant embryos are morphologically normal up to the eight-cell stage but they do not compact, fail to develop into blastocysts and die at the morula stage (PubMed:30111536). Oocyte- specific knockout females are infertile (PubMed:30283081, PubMed:31000741). The ovaries of 8-week-old females are significantly smaller than those of wild-type females and are devoid of follicles containing more than two layers of granulosa cells and corpora lutea. The ovaries are deficient in follicles beyond the secondary follicle stage and contained fewer primordial follicles than the control ovaries. At 5 months of age, oocytes disappear in the ovaries and only primordial and primary follicles are seen in the mutant ovaries (PubMed:30283081). Oocyte-specific maternal knockout embryos display arrest at the two-cell stage (PubMed:31000741). Conditional knockout females under the control of progesterone receptor fail to undergo decidualization (PubMed:35932979). Belongs to the WD repeat DCAF13/WDSOF1 family. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleus nucleolus centrosome cytosol rRNA processing protein ubiquitination cell junction estrogen receptor binding small-subunit processome ribosome biogenesis Cul4-RING E3 ubiquitin ligase complex uc007voc.1 uc007voc.2 uc007voc.3 uc007voc.4 uc007voc.5 
ENSMUST00000022913.6 Dcstamp ENSMUST00000022913.6 dendrocyte expressed seven transmembrane protein, transcript variant 1 (from RefSeq NM_029422.4) B2RT61 DCSTP_MOUSE ENSMUST00000022913.1 ENSMUST00000022913.2 ENSMUST00000022913.3 ENSMUST00000022913.4 ENSMUST00000022913.5 NM_029422 Q6R315 Q7TNI9 Q7TNJ0 Q9D619 Tm7sf4 uc007voi.1 uc007voi.2 uc007voi.3 uc007voi.4 Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions. Interacts with CREB3 (By similarity). Monomer. Homodimer. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 1 (via the C-terminus tail); the interaction induces DCSTAMP redistribution to the endoplasmic reticulum-Golgi intermediate compartment. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 2 (via the C-terminus tail). Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endosome. Note=Localized to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL- induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes. Event=Alternative splicing; Named isoforms=4; Name=1 ; IsoId=Q7TNJ0-1; Sequence=Displayed; Name=2 ; IsoId=Q7TNJ0-2; Sequence=VSP_051763; Name=3 ; IsoId=Q7TNJ0-3; Sequence=VSP_051765; Name=4 ; IsoId=Q7TNJ0-4; Sequence=VSP_051764; Expressed in macrophages and bone marrow dendritic cells (BM-DC). Weakly expressed in the spleen and lymph node. Highly expressed in multi-nuclear osteoclasts compared to mono-nuclear macrophages. Expressed in foreign body giant cells (FBGCs). Isoform 1 and isoform 2 are expressed in osteoclasts. Up-regulated by IL4/interleukin-4, macrophage colony- stimulating factor (M-CSF), receptor activator of NF-KB ligand (RANKL), lipopolysaccharide (LPS) and toll-like receptor (TLR). Up-regulated by TNFSF11-induced osteoclast differentiation in combination with TNF- alpha. Down-regulated upon dendritic cell (DC) maturation. Several domains are necessary for interacting with OS9. The region in the cytoplasmic tail that is necessary for interaction with OS9, is also required for its transport. Glycosylated. Mice show a lack of osteoclast and foreign body giant cells multi-nuclear formation and a bone-resorbing efficiency reduction. Mice show increased bone mass. Older (>12 months) mice suffered from multisystemic inflammations in the kidney, lung and salivary gland. Mice show autoimmune symptoms, like dendritic cells (DC) with increased phagocytotic activity and antigen presentation. immune system process endosome endoplasmic reticulum endoplasmic reticulum membrane plasma membrane cell surface endosome membrane membrane integral component of membrane cell differentiation integral component of endoplasmic reticulum membrane negative regulation of cell growth osteoclast differentiation endoplasmic reticulum-Golgi intermediate compartment membrane positive regulation of macrophage fusion cellular response to macrophage colony-stimulating factor stimulus myeloid dendritic cell differentiation positive regulation of monocyte differentiation positive regulation of bone resorption membrane fusion cellular response to interleukin-4 cellular response to tumor necrosis factor osteoclast fusion uc007voi.1 uc007voi.2 uc007voi.3 uc007voi.4 
ENSMUST00000022915.11 Dpys ENSMUST00000022915.11 dihydropyrimidinase, transcript variant 1 (from RefSeq NM_022722.3) DPYS_MOUSE ENSMUST00000022915.1 ENSMUST00000022915.10 ENSMUST00000022915.2 ENSMUST00000022915.3 ENSMUST00000022915.4 ENSMUST00000022915.5 ENSMUST00000022915.6 ENSMUST00000022915.7 ENSMUST00000022915.8 ENSMUST00000022915.9 NM_022722 Q99PP1 Q9DBK3 Q9DBP7 Q9EQF5 uc007vok.1 uc007vok.2 uc007vok.3 uc007vok.4 Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate (By similarity). Reaction=5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+); Xref=Rhea:RHEA:16121, ChEBI:CHEBI:11892, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15901; EC=3.5.2.2; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Homotetramer. Carboxylation allows a single lysine to coordinate two zinc ions. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. uracil binding thymine binding dihydropyrimidinase activity cytoplasm cytosol pyrimidine nucleobase catabolic process thymine catabolic process uracil catabolic process zinc ion binding amino acid binding hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides beta-alanine metabolic process uracil metabolic process metal ion binding phosphoprotein binding protein homooligomerization protein homotetramerization uc007vok.1 uc007vok.2 uc007vok.3 uc007vok.4 
ENSMUST00000022916.13 Lrp12 ENSMUST00000022916.13 low density lipoprotein-related protein 12, transcript variant 1 (from RefSeq NM_172814.4) ENSMUST00000022916.1 ENSMUST00000022916.10 ENSMUST00000022916.11 ENSMUST00000022916.12 ENSMUST00000022916.2 ENSMUST00000022916.3 ENSMUST00000022916.4 ENSMUST00000022916.5 ENSMUST00000022916.6 ENSMUST00000022916.7 ENSMUST00000022916.8 ENSMUST00000022916.9 LRP12_MOUSE NM_172814 Q8BUJ9 Q8BWM9 uc007vom.1 uc007vom.2 uc007vom.3 Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor (By similarity). May interact with RACK1, ZFYVE9 and NMRK2. Membrane ; Single-pass type I membrane protein Membrane, coated pit Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BUJ9-1; Sequence=Displayed; Name=2; IsoId=Q8BUJ9-2; Sequence=VSP_009821; Belongs to the LDLR family. Sequence=BAC39247.1; Type=Frameshift; Evidence=; neuron migration molecular_function integral component of plasma membrane clathrin-coated pit endocytosis membrane integral component of membrane neuron projection development uc007vom.1 uc007vom.2 uc007vom.3 
ENSMUST00000022921.7 Angpt1 ENSMUST00000022921.7 angiopoietin 1, transcript variant 1 (from RefSeq NM_009640.4) ANGP1_MOUSE Agpt ENSMUST00000022921.1 ENSMUST00000022921.2 ENSMUST00000022921.3 ENSMUST00000022921.4 ENSMUST00000022921.5 ENSMUST00000022921.6 NM_009640 O08538 Q6NWV7 uc007vpc.1 uc007vpc.2 uc007vpc.3 uc007vpc.4 This gene encodes a secreted glycoprotein that belongs to the angiopoietin family of vascular growth factors. The encoded protein is a ligand in the vascular tyrosine kinase signaling pathway and regulates the formation and stabilization of blood vessels. This protein also functions in striated muscles by promoting proliferation, migration and differentiation of skeletal myoblasts and plays an essential role in the vascular response to tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]. Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell- cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme (By similarity). Homooligomer (By similarity). Interacts with TEK/TIE2 (By similarity). Interacts with SVEP1/polydom (PubMed:28179430). Secreted Early in development, at 9 dpc to 11 dpc, it is found most prominently in the heart myocardium surrounding the endocardium. Later, it becomes more widely distributed, most often in the mesenchyme surrounding developing vessels, in close association with endothelial cells. Embryonically lethal. Embryos die at about 12.5 dpc, due to important developmental defects of the endocardium and myocardium, plus generalized defects in vascular development. angiogenesis ovarian follicle development branching involved in blood vessel morphogenesis vasculogenesis in utero embryonic development negative regulation of protein phosphorylation sprouting angiogenesis positive regulation of receptor internalization negative regulation of cytokine secretion involved in immune response endocardium morphogenesis receptor binding vascular endothelial growth factor receptor binding extracellular region extracellular space plasma membrane microvillus negative regulation of cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway activation of transmembrane receptor protein tyrosine kinase activity multicellular organism development endoderm development positive regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase signaling regulation of skeletal muscle satellite cell proliferation hemopoiesis cell differentiation heparin biosynthetic process positive regulation of vascular endothelial growth factor receptor signaling pathway receptor tyrosine kinase binding positive regulation of protein ubiquitination cell-substrate adhesion regulation of tumor necrosis factor production positive regulation of peptidyl-serine phosphorylation protein localization to cell surface negative regulation of protein import into nucleus negative regulation of apoptotic process negative regulation of vascular permeability regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein binding negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration membrane raft positive regulation of cell adhesion Tie signaling pathway positive regulation of peptidyl-tyrosine phosphorylation positive chemotaxis protein homooligomerization positive regulation of protein kinase B signaling cardiac muscle tissue morphogenesis vasculogenesis involved in coronary vascular morphogenesis positive regulation of ERK1 and ERK2 cascade glomerulus vasculature development negative regulation of endothelial cell apoptotic process regulation of macrophage migration inhibitory factor signaling pathway uc007vpc.1 uc007vpc.2 uc007vpc.3 uc007vpc.4 
ENSMUST00000022925.10 Eif3h ENSMUST00000022925.10 eukaryotic translation initiation factor 3, subunit H, transcript variant 1 (from RefSeq NM_080635.2) EIF3H_MOUSE ENSMUST00000022925.1 ENSMUST00000022925.2 ENSMUST00000022925.3 ENSMUST00000022925.4 ENSMUST00000022925.5 ENSMUST00000022925.6 ENSMUST00000022925.7 ENSMUST00000022925.8 ENSMUST00000022925.9 Eif3s3 NM_080635 Q91WK2 uc007vrb.1 uc007vrb.2 uc007vrb.3 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner (By similarity). Interacts with DHX33; the interaction is independent of RNA (PubMed:26100019). Cytoplasm Belongs to the eIF-3 subunit H family. formation of cytoplasmic translation initiation complex cytoplasmic translational initiation translation initiation factor activity cytoplasm cytosol eukaryotic translation initiation factor 3 complex translation translational initiation proteolysis metallopeptidase activity eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex polysomal ribosome eukaryotic translation initiation factor 3 complex, eIF3m uc007vrb.1 uc007vrb.2 uc007vrb.3 
ENSMUST00000022927.11 Rad21 ENSMUST00000022927.11 RAD21 cohesin complex component, transcript variant 1 (from RefSeq NM_009009.5) ENSMUST00000022927.1 ENSMUST00000022927.10 ENSMUST00000022927.2 ENSMUST00000022927.3 ENSMUST00000022927.4 ENSMUST00000022927.5 ENSMUST00000022927.6 ENSMUST00000022927.7 ENSMUST00000022927.8 ENSMUST00000022927.9 Hr21 NM_009009 P70219 Q3TQ09 Q61550 Q810A8 Q91VB9 Q9DBU4 RAD21_MOUSE Scc1 uc007vrd.1 uc007vrd.2 uc007vrd.3 uc007vrd.4 [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (PubMed:18237772). May control RUNX1 gene expression. Binds to and represses APOB gene promoter (By similarity). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). [64-kDa C-terminal product]: May promote apoptosis. Component of the cohesin complex, which consists of an SMC1A/B and SMC3 heterodimer core and 2 non-Smc subunits RAD21 and STAG1/SA1, STAG2/SA2 or STAG3/SA3 (PubMed:10375619, PubMed:18237772). Interacts (via C-terminus) with SMC1A and (via N-terminus) with SMC3; these interactions are direct (By similarity). The cohesin complex interacts with NUMA1. The cohesin complex also interacts with CDCA5, PDS5A and PDS5B; this interaction might regulate the ability of the cohesin complex to mediate sister chromatid cohesion. The interaction with PDS5B is direct and is stimulated by STAG1/SA1. The cohesin complex interacts with the cohesin loading complex subunits NIPBL/Scc2 (via HEAT repeats) and MAU2/Scc4. NIPBL directly contacts all members of the complex, RAD21, SMC1A/B, SMC3 and STAG1 (By similarity). The cohesin complex interacts with DDX11/ChIR1. Directly interacts with WAPL; this interaction is stimulated by STAG1/SA1 (By similarity). Interacts with the ISWI chromatin remodeling complex component SMARCA5; the interaction is direct (By similarity). Interacts with the NuRD complex component CHD4; the interaction is direct (By similarity). [Double-strand-break repair protein rad21 homolog]: Nucleus Chromosome Chromosome, centromere Note=Associates with chromatin. Before prophase, scattered along chromosome arms. During prophase and prometaphase, most cohesins dissociate from the arms of condensing chromosome, possibly through PLK1-mediated phosphorylation (By similarity). A small amount of cohesin remains in centromeric regions and is removed from chromosomes only at the onset of anaphase. At anaphase, cleavage by separase/ESPL1 leads to the dissociation of cohesin from chromosomes and chromosome separation (By similarity). [64-kDa C-terminal product]: Cytoplasm, cytosol Nucleus Widely expressed with highest levels in testis, brain, kidney, heart and thymus. Lowest levels in skeletal muscle. Not regulated during the cell cycle (at protein level). The C-terminal part associates with the ATPase head of SMC1A, while the N-terminal part binds to the ATPase head of SMC3. Cleaved by separase/ESPL1 at the onset of anaphase; this cleavage is required for sister chromatid separation and cytokinesis. Cleaved by caspase-3/CASP3 or caspase-7/CASP7 at the beginning of apoptosis. Phosphorylated; becomes hyperphosphorylated in M phase of cell cycle. The large dissociation of cohesin from chromosome arms during prophase may be partly due to its phosphorylation by PLK1. Seems to bind calcium. Belongs to the rad21 family. chromosome, centromeric region chromatin condensed nuclear chromosome chromatin binding protein binding nucleus nucleoplasm chromosome cytoplasm cytosol DNA repair double-strand break repair regulation of transcription from RNA polymerase II promoter apoptotic process cellular response to DNA damage stimulus cell cycle chromosome segregation sister chromatid cohesion multicellular organism development cohesin complex negative regulation of G2/M transition of mitotic cell cycle nuclear matrix meiotic cohesin complex negative regulation of mitotic metaphase/anaphase transition positive regulation of sister chromatid cohesion cell division meiotic cell cycle protein localization to chromatin uc007vrd.1 uc007vrd.2 uc007vrd.3 uc007vrd.4 
ENSMUST00000022945.9 Shcbp1 ENSMUST00000022945.9 Shc SH2-domain binding protein 1 (from RefSeq NM_011369.4) ENSMUST00000022945.1 ENSMUST00000022945.2 ENSMUST00000022945.3 ENSMUST00000022945.4 ENSMUST00000022945.5 ENSMUST00000022945.6 ENSMUST00000022945.7 ENSMUST00000022945.8 NM_011369 Pal Q3UED9 Q3UMD9 Q9Z179 SHCBP_MOUSE uc009kua.1 uc009kua.2 uc009kua.3 May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. Interacts directly with isoform p52shc of SHC1 via its SH2 domain (PubMed:10086341). Interacts with TRIM71; leading to enhanced SHCBP1 protein stability (PubMed:22508726). Interacts with both members of the centralspindlin complex, KIF23 and RACGAP1 (By similarity). Q9Z179; P98083: Shc1; NbExp=5; IntAct=EBI-644352, EBI-300201; Midbody Cytoplasm, cytoskeleton, spindle Note=Displays weak localization to the spindle midzone in some early telophase cells and is concentrated at the midbody in late cytokinesis. Expressed in spleen, lung and heart with higher expression in testis. No expression in brain, liver and skeletal muscle. Elevated expression in actively cycling cells. Down-regulated upon growth inhibition. protein binding cellular_component cytoplasm spindle cytoskeleton fibroblast growth factor receptor signaling pathway midbody SH2 domain binding regulation of neural precursor cell proliferation uc009kua.1 uc009kua.2 uc009kua.3 
ENSMUST00000022946.6 Rida ENSMUST00000022946.6 reactive intermediate imine deaminase A homolog (from RefSeq NM_008287.3) ENSMUST00000022946.1 ENSMUST00000022946.2 ENSMUST00000022946.3 ENSMUST00000022946.4 ENSMUST00000022946.5 Hrp12 NM_008287 P52760 Q569N4 RIDA_MOUSE Rida uc007vlt.1 uc007vlt.2 uc007vlt.3 uc007vlt.4 Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'- phosphate-dependent dehydratases including L-threonine dehydratase. Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'- GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage. Reaction=2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+); Xref=Rhea:RHEA:39975, ChEBI:CHEBI:15377, ChEBI:CHEBI:16763, ChEBI:CHEBI:28938, ChEBI:CHEBI:76545; EC=3.5.99.10; Evidence=; Reaction=2-iminopropanoate + H2O = NH4(+) + pyruvate; Xref=Rhea:RHEA:40671, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:44400; EC=3.5.99.10; Evidence=; Homotrimer. Interacts with YTHDF2. Cytoplasm Nucleus Peroxisome Mitochondrion Note=Mostly cytoplasmic but, in less differentiated cells occasionally nuclear. Expressed predominantly in liver and kidney. Lower levels in lung and brain. Belongs to the RutC family. Sequence=AAA96033.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; kidney development RNA binding mRNA binding nucleus cytoplasm mitochondrion mitochondrial matrix peroxisome cytosol mRNA catabolic process brain development hydrolase activity endoribonuclease activity, producing 3'-phosphomonoesters negative regulation of translation deaminase activity lung development response to lipid long-chain fatty acid binding protein homodimerization activity ion binding transition metal ion binding negative regulation of epithelial cell proliferation mRNA destabilization G1 to G0 transition RNA phosphodiester bond hydrolysis, endonucleolytic organonitrogen compound catabolic process response to salt uc007vlt.1 uc007vlt.2 uc007vlt.3 uc007vlt.4 
ENSMUST00000022953.10 Fam135b ENSMUST00000022953.10 family with sequence similarity 135, member B (from RefSeq NM_177819.3) ENSMUST00000022953.1 ENSMUST00000022953.2 ENSMUST00000022953.3 ENSMUST00000022953.4 ENSMUST00000022953.5 ENSMUST00000022953.6 ENSMUST00000022953.7 ENSMUST00000022953.8 ENSMUST00000022953.9 F135B_MOUSE NM_177819 Q9DAI6 uc011ztr.1 uc011ztr.2 uc011ztr.3 Belongs to the FAM135 family. Sequence=AAI19175.1; Type=Erroneous initiation; Evidence=; Sequence=BAB24252.2; Type=Erroneous initiation; Evidence=; cellular_component cellular lipid metabolic process uc011ztr.1 uc011ztr.2 uc011ztr.3 
ENSMUST00000022954.7 Khdrbs3 ENSMUST00000022954.7 KH domain containing, RNA binding, signal transduction associated 3, transcript variant 1 (from RefSeq NM_010158.3) ENSMUST00000022954.1 ENSMUST00000022954.2 ENSMUST00000022954.3 ENSMUST00000022954.4 ENSMUST00000022954.5 ENSMUST00000022954.6 KHDR3_MOUSE NM_010158 O88624 Q9R226 Salp Slm2 uc007wbf.1 uc007wbf.2 uc007wbf.3 RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro (PubMed:19457263). Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides (By similarity). Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:15471878). Involved in splice site selection of vascular endothelial growth factor (By similarity). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members. High concentrations in forebrain structures block splicing inclusion of NRXN1-3 AS4 exons while low concentrations favor their inclusion. Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity and is linked to behavioral aspects (PubMed:22196734, PubMed:23637638, PubMed:24469635, PubMed:27174676). Regulates expression of KHDRBS2/SLIM-1 in defined neuron populations in the hippocampus by modifying its alternative splicing resulting in a transcript predicted to undergo nonsense- mediated decay (PubMed:25505328). Can bind FABP9 mRNA (PubMed:19916944). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Self-associates to form homooligomers; dimerization increases RNA affinity (By similarity). Interacts with KHDRBS2/SLM-1 (By similarity). Interacts with KHDRBS1/SAM68; heterooligomer formation of KHDRBS family proteins may modulate RNA substrate specificity (PubMed:10077576). Interacts with the splicing regulatory proteins SFRS9, SAFB and YTHDC1. Interacts with HNRPL, RBMX, RBMY1A1, p85 subunit of PI3-kinase, SERPINB5 (By similarity). Nucleus te=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one. Highly expressed in testis and brain. In adult cerebellum expressed predominantly in internal granular layer interneurons and in hippocampus is exclusively expressed in CA neurons; expression is restricted to neuronal subpopulations largely non- overlapping with expression of KHDRBS2/SLM-1. In the developing cerebellum expression is decreasing in the first 3 postnatal weeks. The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase. Phosphorylated on tyrosine residues by PTK6. Belongs to the KHDRBS family. nucleic acid binding RNA binding single-stranded RNA binding nucleus nucleoplasm mRNA processing SH3 domain binding protein domain specific binding positive regulation of RNA splicing identical protein binding regulation of mRNA splicing, via spliceosome protein oligomerization uc007wbf.1 uc007wbf.2 uc007wbf.3 
ENSMUST00000022960.4 Eif3e ENSMUST00000022960.4 eukaryotic translation initiation factor 3, subunit E (from RefSeq NM_008388.2) EIF3E EIF3S6 ENSMUST00000022960.1 ENSMUST00000022960.2 ENSMUST00000022960.3 Eif3e Eif3s6 INT6 NM_008388 Q3UIG0 Q3UIG0_MOUSE uc007vpk.1 uc007vpk.2 uc007vpk.3 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2. Cytoplasm Nucleus Nucleus, PML body Phosphorylated upon DNA damage, probably by ATM or ATR. Belongs to the eIF-3 subunit E family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay formation of cytoplasmic translation initiation complex cytoplasmic translational initiation translation initiation factor activity nucleus cytoplasm cytosol eukaryotic translation initiation factor 3 complex translation translational initiation eukaryotic 43S preinitiation complex nuclear body PML body eukaryotic 48S preinitiation complex positive regulation of translation protein N-terminus binding eukaryotic translation initiation factor 3 complex, eIF3e positive regulation of mRNA binding uc007vpk.1 uc007vpk.2 uc007vpk.3 
ENSMUST00000022962.8 Emc2 ENSMUST00000022962.8 ER membrane protein complex subunit 2, transcript variant 1 (from RefSeq NM_025736.3) EMC2_MOUSE ENSMUST00000022962.1 ENSMUST00000022962.2 ENSMUST00000022962.3 ENSMUST00000022962.4 ENSMUST00000022962.5 ENSMUST00000022962.6 ENSMUST00000022962.7 Emc2 Kiaa0103 NM_025736 Q925K1 Q9CRD2 Ttc35 uc007vpm.1 uc007vpm.2 uc007vpm.3 Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N- exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Component of the ER membrane protein complex (EMC). Interacts with WNK1 (via amphipathic alpha-helix region); promoting the ER membrane protein complex assembly by preventing EMC2 ubiquitination. Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Note=May also localize to the nuclear envelope. Ubiquitinated when soluble in the cytoplasm, leading to its degradation by the proteasome. Interaction with EMC2 prevents its ubiquitination and degradation. Belongs to the EMC2 family. molecular_function nucleus cytoplasm mitochondrion endoplasmic reticulum ER membrane protein complex uc007vpm.1 uc007vpm.2 uc007vpm.3 
ENSMUST00000022967.7 Kcnv1 ENSMUST00000022967.7 potassium channel, subfamily V, member 1 (from RefSeq NM_026200.3) ENSMUST00000022967.1 ENSMUST00000022967.2 ENSMUST00000022967.3 ENSMUST00000022967.4 ENSMUST00000022967.5 ENSMUST00000022967.6 KCNV1_MOUSE NM_026200 Q8BK61 Q8BYS7 Q8BZN2 Q9CZR1 uc007vql.1 uc007vql.2 uc007vql.3 uc007vql.4 Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity). Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 (By similarity). Cell membrane ; Multi-pass membrane protein Note=Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2 (By similarity). The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane regulation of ion transmembrane transport protein homooligomerization transmembrane transport potassium ion transmembrane transport uc007vql.1 uc007vql.2 uc007vql.3 uc007vql.4 
ENSMUST00000022976.6 Washc5 ENSMUST00000022976.6 WASH complex subunit 5 (from RefSeq NM_153548.3) ENSMUST00000022976.1 ENSMUST00000022976.2 ENSMUST00000022976.3 ENSMUST00000022976.4 ENSMUST00000022976.5 Kiaa0196 NM_153548 Q8BGY1 Q8C2E7 Q8K2J2 WASC5_MOUSE Washc5 uc007vxt.1 uc007vxt.2 uc007vxt.3 Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (By similarity). Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation (PubMed:24998208). Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASH (WASHC1, WASH2P or WASH3P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. The WASH core complex associates via WASHC2 with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex. Interacts with VCP, PI4K2A (By similarity). Cytoplasm, cytosol Endoplasmic reticulum Early endosome Note=Colocalizes with SYP/synaptophysin in the external molecular layer of the dentate gyrus and in motoneurons of the ventral horn of spinal cord. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C2E7-1; Sequence=Displayed; Name=2; IsoId=Q8C2E7-2; Sequence=VSP_010323, VSP_010324; Belongs to the strumpellin family. oocyte maturation molecular_function nucleoplasm cytoplasm endosome early endosome endoplasmic reticulum cytosol positive regulation of neuron projection development protein transport endosomal transport polar body extrusion after meiotic divisions cholesterol homeostasis neuron projection neuronal cell body WASH complex spindle assembly involved in meiosis uc007vxt.1 uc007vxt.2 uc007vxt.3 
ENSMUST00000022977.14 Sqle ENSMUST00000022977.14 squalene epoxidase (from RefSeq NM_009270.3) ENSMUST00000022977.1 ENSMUST00000022977.10 ENSMUST00000022977.11 ENSMUST00000022977.12 ENSMUST00000022977.13 ENSMUST00000022977.2 ENSMUST00000022977.3 ENSMUST00000022977.4 ENSMUST00000022977.5 ENSMUST00000022977.6 ENSMUST00000022977.7 ENSMUST00000022977.8 ENSMUST00000022977.9 NM_009270 Q3TQK8 Q3TQK8_MOUSE Sqle uc007vxq.1 uc007vxq.2 uc007vxq.3 Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. Reaction=O2 + reduced [NADPH--hemoprotein reductase] + squalene = (S)- 2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:25282, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15440, ChEBI:CHEBI:15441, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.17; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Endoplasmic reticulum membrane ; Peripheral membrane protein Belongs to the squalene monooxygenase family. squalene monooxygenase activity cellular aromatic compound metabolic process cholesterol metabolic process response to organic substance membrane integral component of membrane sterol biosynthetic process regulation of cell proliferation intracellular membrane-bounded organelle flavin adenine dinucleotide binding oxidation-reduction process FAD binding uc007vxq.1 uc007vxq.2 uc007vxq.3 
ENSMUST00000022980.5 Ndufb9 ENSMUST00000022980.5 NADH:ubiquinone oxidoreductase subunit B9, transcript variant 1 (from RefSeq NM_023172.4) ENSMUST00000022980.1 ENSMUST00000022980.2 ENSMUST00000022980.3 ENSMUST00000022980.4 NDUB9_MOUSE NM_023172 Q9CQJ8 uc007vtw.1 uc007vtw.2 uc007vtw.3 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Mammalian complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the complex I LYR family. mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial electron transport, NADH to ubiquinone membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc007vtw.1 uc007vtw.2 uc007vtw.3 
ENSMUST00000022985.2 Klhl38 ENSMUST00000022985.2 kelch-like 38 (from RefSeq NM_177755.3) ENSMUST00000022985.1 KLH38_MOUSE NM_177755 Q8BSF5 uc007vtl.1 uc007vtl.2 uc007vtl.1 uc007vtl.2 
ENSMUST00000022986.8 Fbxo32 ENSMUST00000022986.8 F-box protein 32 (from RefSeq NM_026346.3) ENSMUST00000022986.1 ENSMUST00000022986.2 ENSMUST00000022986.3 ENSMUST00000022986.4 ENSMUST00000022986.5 ENSMUST00000022986.6 ENSMUST00000022986.7 FBX32_MOUSE NM_026346 Q9CPU7 uc007vtk.1 uc007vtk.2 uc007vtk.3 uc007vtk.4 uc007vtk.5 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity). Protein modification; protein ubiquitination. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32. Cytoplasm Nucleus Note=Shuttles between cytoplasm and the nucleus. Specifically expressed in cardiac and skeletal muscle. protein binding nucleus nucleoplasm cytoplasm cytosol negative regulation of cardiac muscle hypertrophy positive regulation of cardiac muscle cell apoptotic process response to electrical stimulus involved in regulation of muscle adaptation muscle atrophy response to denervation involved in regulation of muscle adaptation protein ubiquitination SCF ubiquitin ligase complex Z disc cellular response to dexamethasone stimulus uc007vtk.1 uc007vtk.2 uc007vtk.3 uc007vtk.4 uc007vtk.5 
ENSMUST00000022992.13 Tbc1d31 ENSMUST00000022992.13 TBC1 domain family, member 31, transcript variant 3 (from RefSeq NM_001356310.1) ENSMUST00000022992.1 ENSMUST00000022992.10 ENSMUST00000022992.11 ENSMUST00000022992.12 ENSMUST00000022992.2 ENSMUST00000022992.3 ENSMUST00000022992.4 ENSMUST00000022992.5 ENSMUST00000022992.6 ENSMUST00000022992.7 ENSMUST00000022992.8 ENSMUST00000022992.9 NM_001356310 Q3TBW4 Q3U4F6 Q5KSA3 Q6NXY1 Q810J7 Q8C3Y2 TBC31_MOUSE Tbc1d31 Wdr67 uc007vsv.1 uc007vsv.2 uc007vsv.3 Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation. Interacts with PJA2; the interaction is direct and recruits PJA2 to centrosomes. Interacts with OFD1; regulates its activity in cilium assembly. Interacts with PRKACA. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cytoplasm, cytoskeleton, cilium basal body Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NXY1-1; Sequence=Displayed; Name=2; IsoId=Q6NXY1-4; Sequence=VSP_016185, VSP_016186, VSP_016187; Sequence=BAD83881.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAE32475.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=BAE42193.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; molecular_function centrosome biological_process uc007vsv.1 uc007vsv.2 uc007vsv.3 
ENSMUST00000022993.7 Derl1 ENSMUST00000022993.7 Der1-like domain family, member 1 (from RefSeq NM_024207.4) DERL1_MOUSE Der1 Derl1 ENSMUST00000022993.1 ENSMUST00000022993.2 ENSMUST00000022993.3 ENSMUST00000022993.4 ENSMUST00000022993.5 ENSMUST00000022993.6 NM_024207 Q3U6Z2 Q99J56 Q9D918 uc007vsq.1 uc007vsq.2 uc007vsq.3 Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane. This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome. The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress- induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Homotetramer (By similarity). The four subunits of the tetramer are arranged in a twofold symmetry (By similarity). Forms homo- and heterooligomers with DERL2 and DERL3; binding to DERL3 is poorer than that between DERL2 and DERL3. Interacts (via SHP-box motif) with VCP (By similarity). Interacts with AMFR, SELENOS, SEL1L, SELENOK and SYVN1, as well as with SEL1L-SYVN1 and VCP-SELENOS protein complexes; this interaction is weaker than that observed between DERL2 and these complexes. Interacts with NGLY1 and YOD1. Does not bind to EDEM1 (By similarity). Interacts with DNAJB9 (PubMed:22267725). Interacts with RNF103. Interacts with HM13. Interacts with XBP1 isoform 1 (via luminal/ectodomain domain); the interaction obviates the need for ectodomain shedding prior HM13/SPP-mediated XBP1 isoform 1 cleavage. Interacts with the signal recognition particle/SRP and the SRP receptor; in the process of endoplasmic reticulum stress-induced pre-emptive quality control. May interact with UBXN6 (By similarity). Interacts with ZFAND2B; probably through VCP (PubMed:24160817). Interacts with CCDC47 (PubMed:25009997). Interacts with C18orf32 (By similarity). May interact with TRAM1 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Widely expressed, with lowest levels in brain and heart. Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR). Belongs to the derlin family. Hrd1p ubiquitin ligase ERAD-L complex protease binding protein binding early endosome late endosome endoplasmic reticulum signal recognition particle receptor complex endoplasmic reticulum membrane response to unfolded protein protein transport membrane integral component of membrane integral component of endoplasmic reticulum membrane ER-associated ubiquitin-dependent protein catabolic process endoplasmic reticulum unfolded protein response retrograde protein transport, ER to cytosol positive regulation of protein ubiquitination ubiquitin protein ligase binding protein destabilization positive regulation of protein binding cellular response to unfolded protein Derlin-1-VIMP complex ERAD pathway Derlin-1 retrotranslocation complex MHC class I protein binding identical protein binding proteasome-mediated ubiquitin-dependent protein catabolic process signal recognition particle ATPase binding protein homooligomerization misfolded protein binding ER-associated misfolded protein catabolic process ubiquitin-specific protease binding uc007vsq.1 uc007vsq.2 uc007vsq.3 
ENSMUST00000022998.14 Mtbp ENSMUST00000022998.14 Mdm2, transformed 3T3 cell double minute p53 binding protein, transcript variant 8 (from RefSeq NR_183253.1) ENSMUST00000022998.1 ENSMUST00000022998.10 ENSMUST00000022998.11 ENSMUST00000022998.12 ENSMUST00000022998.13 ENSMUST00000022998.2 ENSMUST00000022998.3 ENSMUST00000022998.4 ENSMUST00000022998.5 ENSMUST00000022998.6 ENSMUST00000022998.7 ENSMUST00000022998.8 ENSMUST00000022998.9 MTBP_MOUSE NR_183253 Q80VU3 Q8BJS8 Q8BTU9 Q8BTW0 Q99K25 Q9ER61 uc007vsi.1 uc007vsi.2 May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. Interacts with MDM2. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BJS8-1; Sequence=Displayed; Name=2; IsoId=Q8BJS8-2; Sequence=VSP_032106, VSP_032107; Name=3; IsoId=Q8BJS8-3; Sequence=VSP_032105; Expressed in small intestine and spleen at low levels, in the ovary at intermediate levels and in the testis and thymus at high levels. Death between E3.5 and E7.5. Mice containing a heterozygous deletion of this gene coupled with heterozygous deletion of TP53 exhibit an increased incidence of metastatic tumors. Belongs to the MTBP family. kinetochore chromatin protein binding cell cycle cell cycle arrest traversing start control point of mitotic cell cycle negative regulation of cell proliferation regulation of protein ubiquitination protein localization to kinetochore negative regulation of mitotic nuclear division uc007vsi.1 uc007vsi.2 
ENSMUST00000023006.7 Dnaaf11 ENSMUST00000023006.7 dynein axonemal assembly factor 11 (from RefSeq NM_019457.2) DAA11_MOUSE ENSMUST00000023006.1 ENSMUST00000023006.2 ENSMUST00000023006.3 ENSMUST00000023006.4 ENSMUST00000023006.5 ENSMUST00000023006.6 Lrrc6 Lrtp Mc2 NM_019457 O88978 Q9CUG2 uc011ztm.1 uc011ztm.2 Involved in dynein arm assembly, is important for expression and transporting outer dynein arm (ODA) proteins from the cytoplasm to the cilia (PubMed:27353389). Acts as a crucial component in the formation and motility of spermatozoal flagella (By similarity). Interacts (via CS domain) with ZMYND10 (via C-terminus). Cytoplasm ll projection, cilium Dynein axonemal particle Cell projection, cilium, flagellum Mainly expressed in cells with motile cilia (PubMed:27353389). Expressed in epithelial cells of the trachea, testis and ependymal cells of the cerebral ventricles (PubMed:27353389). In testis, abundant expression in late prophase of meiosis I with a dramatic decrease after the first meiotic division (at protein level) (PubMed:10775177). At the embryonic day 8.0 dpc, expressed at the node, especially in pit cells, which are located at the central region of the node and possess motile cilia. At later stages, expression is detected in the notochord at 9.0 dpc, in the hindbrain, the branchial arches and neural tube at 11.0 dpc, in the hindbrain at 12.0 dpc and in the forebrain at 13.0 dpc. Mutant mice show primary ciliary dyskinesia defects such as hydrocephalus and laterality defects and die within 5 weeks of birth. The morphology of mutant motile cilia is normal, but their motility is completely lost. The 9 + 2 arrangement of microtubules remain normal in mutants, but the outer dynein arms (ODAs) is absent from the cilia. Belongs to the tilB family. cilium movement molecular_function extracellular region cytoplasm cilium male gonad development flagellated sperm motility outer dynein arm assembly inner dynein arm assembly cell projection motile cilium assembly epithelial cilium movement involved in determination of left/right asymmetry reproductive system development uc011ztm.1 uc011ztm.2 
ENSMUST00000023007.7 Adcy8 ENSMUST00000023007.7 adenylate cyclase 8, transcript variant 1 (from RefSeq NM_009623.2) ADCY8_MOUSE Adcy8 ENSMUST00000023007.1 ENSMUST00000023007.2 ENSMUST00000023007.3 ENSMUST00000023007.4 ENSMUST00000023007.5 ENSMUST00000023007.6 G3X8V9 NM_009623 P97490 uc007vzo.1 uc007vzo.2 uc007vzo.3 Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion (PubMed:10864938, PubMed:25403481, PubMed:10482244, PubMed:14585998, PubMed:18448650). Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation (PubMed:10482244, PubMed:14585998, PubMed:18448650, PubMed:10864938, PubMed:12441059, PubMed:20638449, PubMed:27234425, PubMed:18222416). Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment (PubMed:25403481). Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells (By similarity). Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro). ; At rest, the N- and C-terminal domains interact, as part of a larger autoinhibitory complex, with calmodulin pre- associated at the N-terminal domain. Upon a calcium rise, calmodulin becomes calcium-saturated and subsequently binds to the C-terminal domain. Fully calcium-saturated calmodulin then leaves the N-terminal domain, binding solely to the C-terminal domain, and the whole autoinhibitory complex dissociates, resulting in activation of adenylate cyclase. As local calcium concentrations decrease, the calmodulin becomes calcium free and binds once more to the N-terminal domain, whereupon the whole system returns to rest with the re- association of the autoinhibitory complex (PubMed:14585998). In non- excitable cells, activated by capacitative calcium entry (CCE) through store-operated channels, namely through interaction with ORAI1 and STIM1; membrane raft and caveolae localization and membrane integrity are indispensable. CCE-mediated adenylate cyclase activity is decreased by AKAP5 and AKAP7. CCE-mediated adenylate cyclase activity is up- regulated by AKAP9 and the mitochondrially targeted AKAP1. In excitable cells, activated during membrane depolarization through L-type voltage- gated calcium channels (VGCC), leading to calcium entry; the L-type alpha subunit is sufficient. Activated via stimulation of the GLP1R. Synergistically activated by calcium/calmodulin and GNAS. Stimulated by forskolin. Inhibited by PKA directly bound to AKAP5 at membrane raft. Inhibition by acute activation of OPRM1 and activation by chronic activation of OPRM1 is mediated by pertussis toxin-sensitive G(i) and G(o) G alpha proteins and G beta-gamma dimer. Activity is inhibited by G beta-gamma dimer (By similarity). Homodimer; via transmembrane domain (PubMed:19158400). Monomer (PubMed:19158400). Heterodimer. Oligemer; via transmembrane domain. Interacts with PRKAR2A and AKAP5; inhibits adenylate cyclase activity through PKA phosphorylation. Interacts with PPP2CA and PPP2R1A; does not mediate the inhibitory effects of PKA on adenylate cyclase activity; interaction is dependent of catalytically active PPP2CA; antagonizes interaction with calmodulin. Interacts with AKAP5 (palmitoylated form); promotes the phosphorylation of ADCY8 after store-operated calcium entry (SOCE) stimulation at membrane raft. Interacts with ORAI1; interaction is calcium store depletion independent; interaction occurs in membrane raft; interaction increases markedly after store depletion; positively regulates SOCE-induced adenylate cyclase activity; contributes to the targeting of ADCY8 to discrete regions of the plasma membrane that are shielded from other calcium events. Interacts with STIM1. Interacts with actin; interaction is calcium independent; interaction is affected by calcium-calmodulin; interaction controls the distribution and regulation of ADCY8. Interacts with calmodulin; at rest, interacts via N-terminal domain; upon a calcium rise, calmodulin becomes calcium-saturated and subsequently binds to the C-terminal domain forming an autoinhibitory complex; fully calcium-saturated calmodulin leaves the N-terminal domain, binding solely to the C-terminal domain leading to dissociation of autoinhibitory complex and resulting in activation of adenylate cyclase; antagonizes interaction with PPP2CA; interaction is calcium dependent. Interacts with PPP2R5D (By similarity). Cell membrane ; Multi-pass membrane protein. Basolateral cell membrane Apical cell membrane Synapse Cell projection, dendrite ll projection, axon Presynaptic cell membrane stsynaptic density Membrane raft Membrane, coated pit Cytoplasmic vesicle, clathrin-coated vesicle membrane Membrane, caveola Note=Localized to dendritic arbors (PubMed:17335981). Monomeric N-glycosylated species localizes in membrane raft. In contrast, monomeric unglycosylated forms are enriched in clathrin-coated pits and vesicles. Dimers are also localized outside of membrane rafts. Membrane raft localization and integrity is indispensable for CCE-stimulated adenylate cyclase activity (By similarity). Abundantly expressed within the olfactory bulb, thalamus, habenula, CA1 region of the hippocampus, and hypothalamus (PubMed:10864938). Strongly expressed in pyramidal cells of CA1 and weakly in CA3 and the dentate gyrus. Strongly and homogeneously expressed in all cell layers of the anterior cingulate cortex (ACC). Widely expressed in the insular cortex. Weakly expressed in the spinal dorsal horn (PubMed:12441059). Abundantly present in the CA1/CA2 region in the hippocampus neonatal and intensifies by adulthood. Weakly expressed in the cerebellum at postnatal day 7 and decreased further by postnatal day 14 (PubMed:17335981). The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate- binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain. The two transmembrane clusters are necessary and suficient for the plasma membrane targeting and oligomers assembly. The N-terminal and C-terminal domains interact at rest as part of a larger autoinhibitory complex, with calmodulin pre-associated at the N-terminal domain; the binding is specifically inhibited by fully calcium-saturated calmodulin, resulting in activation of AC8. Phosphorylated by PKA; mediates inhibition of adenylate cyclase activity at membrane raft; does not influence either CALM1 or PPP2CA interaction with ADCY8. N-glycosylated; N-glycosylation is responsible for raft-targeting; is not necessary for CCE-stimulated adenylate cyclase activity. Adcy8 knockout mice are fertile and seem normal. However mice reveal a tendency for both male and female to be somewhat smaller from day of life 45 and 30 respectively while food intake is normal. From there, females remain 10-15% smaller. In contrast, male transiently grew more slowly between day of life 45 and 92, after which point differences are not significant. Mice are less nervous. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding actin binding adenylate cyclase activity protein binding calmodulin binding ATP binding plasma membrane integral component of plasma membrane caveola clathrin-coated pit cAMP biosynthetic process adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration memory long-term memory locomotory behavior protein C-terminus binding calcium- and calmodulin-responsive adenylate cyclase activity cyclic nucleotide biosynthetic process glucose mediated signaling pathway postsynaptic density membrane integral component of membrane basolateral plasma membrane apical plasma membrane lyase activity phosphorus-oxygen lyase activity phosphatase binding cAMP-mediated signaling cell junction axon dendrite clathrin-coated vesicle membrane cytoplasmic vesicle positive regulation of synaptic plasticity positive regulation of CREB transcription factor activity neuronal cell body membrane activation of protein kinase A activity intracellular signal transduction positive regulation of insulin secretion involved in cellular response to glucose stimulus opioid receptor signaling pathway glucose homeostasis presynaptic membrane protein homodimerization activity cell projection plasma membrane raft membrane raft synapse postsynaptic membrane metal ion binding protein heterodimerization activity protein dimerization activity protein N-terminus binding presynaptic active zone modulation of synaptic transmission protein oligomerization protein homooligomerization regulation of cytosolic calcium ion concentration protein phosphatase 2A binding excitatory synapse cellular response to calcium ion cellular response to morphine cellular response to glucose stimulus cellular response to glucagon stimulus regulation of cellular response to stress glutamatergic synapse integral component of presynaptic membrane positive regulation of long-term synaptic potentiation positive regulation of long term synaptic depression cellular response to forskolin actin cytoskeleton uc007vzo.1 uc007vzo.2 uc007vzo.3 
ENSMUST00000023019.12 Trmu ENSMUST00000023019.12 tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase (from RefSeq NM_028063.2) ENSMUST00000023019.1 ENSMUST00000023019.10 ENSMUST00000023019.11 ENSMUST00000023019.2 ENSMUST00000023019.3 ENSMUST00000023019.4 ENSMUST00000023019.5 ENSMUST00000023019.6 ENSMUST00000023019.7 ENSMUST00000023019.8 ENSMUST00000023019.9 MTU1_MOUSE Mtu1 NM_028063 Q9DAT5 Trmt1 uc007xdr.1 uc007xdr.2 uc007xdr.3 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. Reaction=5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L- cysteinyl-[protein] = 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]; Xref=Rhea:RHEA:47040, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11726, Rhea:RHEA-COMP:11732, Rhea:RHEA-COMP:11733, ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:17499, ChEBI:CHEBI:29950, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:61963, ChEBI:CHEBI:87171, ChEBI:CHEBI:87172, ChEBI:CHEBI:456215; EC=2.8.1.14; Evidence=; Mitochondrion Widely expressed but most abundant in tissues with high metabolic rate including heart, liver and brain. Expression is low in spleen, testis, lung and skeletal muscle. Also expressed in inner ear. During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards the activated C2 atom on U34. Subsequently, a transient disulfide bond is formed between the two active site cysteine residues (By similarity). Belongs to the MnmA/TRMU family. Was originally thought to be a 5-methylaminomethyl-2- methyltransferase involved in tRNA modification. tRNA binding nucleotide binding tRNA wobble position uridine thiolation RNA binding ATP binding nucleoplasm mitochondrion tRNA processing transferase activity sulfurtransferase activity uc007xdr.1 uc007xdr.2 uc007xdr.3 
ENSMUST00000023024.8 Tef ENSMUST00000023024.8 thyrotroph embryonic factor, transcript variant 1 (from RefSeq NM_017376.3) ENSMUST00000023024.1 ENSMUST00000023024.2 ENSMUST00000023024.3 ENSMUST00000023024.4 ENSMUST00000023024.5 ENSMUST00000023024.6 ENSMUST00000023024.7 NM_017376 Q3U426 Q3UGF4 Q3UM49 Q3URC8 Q6QHT6 Q8C6I0 Q8VD02 Q9JLC6 TEF_MOUSE uc007wxk.1 uc007wxk.2 uc007wxk.3 uc007wxk.4 Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'- [TC][AG][AG]TTA[TC][AG]-3' (By similarity). Also activates the telokin promoter in smooth muscle-specific and calcium-dependent manner. Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP (By similarity). Nucleus Event=Alternative promoter usage; Named isoforms=3; Name=Alpha; IsoId=Q9JLC6-1; Sequence=Displayed; Name=Beta; IsoId=Q9JLC6-2; Sequence=VSP_011245; Name=2; IsoId=Q9JLC6-3; Sequence=VSP_011246; Isoform Alpha and isoform Beta are expressed at high levels in lung, bladder, kidney, gut and brain. Accumulates according to a robust circadian rhythm in liver and kidney. In liver nuclei, the amplitude of daily oscillation has been estimated to be 9-fold. Expressed at nearly constant level in the brain. Mice deficient for all three PAR bZIP proteins (DBP, HLF and TEF) display a dramatically shortened life span and are highly susceptible to generalized spontaneous and audiogenic epilepsies (due for example to the noise of a vacuum cleaner) that are frequently lethal. The down-regulation of pyridoxal kinase (Pdxk) expression in these mice may participate in this seizure phenotype. Belongs to the bZIP family. PAR subfamily. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein homodimerization activity sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity rhythmic process uc007wxk.1 uc007wxk.2 uc007wxk.3 uc007wxk.4 
ENSMUST00000023029.15 L3mbtl2 ENSMUST00000023029.15 L3MBTL2 polycomb repressive complex 1 subunit, transcript variant 2 (from RefSeq NM_145993.5) ENSMUST00000023029.1 ENSMUST00000023029.10 ENSMUST00000023029.11 ENSMUST00000023029.12 ENSMUST00000023029.13 ENSMUST00000023029.14 ENSMUST00000023029.2 ENSMUST00000023029.3 ENSMUST00000023029.4 ENSMUST00000023029.5 ENSMUST00000023029.6 ENSMUST00000023029.7 ENSMUST00000023029.8 ENSMUST00000023029.9 LMBL2_MOUSE NM_145993 P59178 Q8BHD5 uc007wwu.1 uc007wwu.2 uc007wwu.3 Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity). Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2. Nucleus Ubiquitous. Phosphorylated. protein binding nucleus chromatin organization regulation of transcription, DNA-templated ectoderm development zinc ion binding negative regulation of gene expression positive regulation of histone methylation methylated histone binding negative regulation of histone acetylation histone binding metal ion binding stem cell differentiation stem cell proliferation promoter-specific chromatin binding uc007wwu.1 uc007wwu.2 uc007wwu.3 
ENSMUST00000023036.7 Rbx1 ENSMUST00000023036.7 ring-box 1 (from RefSeq NM_019712.3) ENSMUST00000023036.1 ENSMUST00000023036.2 ENSMUST00000023036.3 ENSMUST00000023036.4 ENSMUST00000023036.5 ENSMUST00000023036.6 NM_019712 P62878 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 RBX1_MOUSE Rbx1 uc007wwq.1 uc007wwq.2 uc007wwq.3 E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:22118460, PubMed:33590678). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components (By similarity). As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate (By similarity). Probably also stimulates CDC34 autoubiquitination (By similarity). May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair (By similarity). Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M (By similarity). Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity). In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (By similarity). As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Reaction=S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.; EC=2.3.2.32; Evidence=; Protein modification; protein ubiquitination. Interacts with COPS6. Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. Part of an E3 ligase complex composed of RBX1, DDB1, DDB2 and CUL4A or CUL4B (PubMed:22118460). Interacts with CAND1 (PubMed:22118460). Interacts with UBE2M (By similarity). Part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1 and FBXW8. Part of CBC(VHL) complexes with elongin BC complex (ELOB and ELOC), CUL2 or CUL5 and VHL. Part of the CSA complex (DCX(ERCC8) complex), a DCX E3 ubiquitin-protein ligase complex containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II (By similarity). Part of multisubunit E3 ubiquitin ligase complexes with elongin BC complex (ELOB and ELOC), CUL2 and MED8; elongin BC complex (ELOB and ELOC), CUL5 and MUF1. Part of multisubunit complexes with elongin BC complex (ELOB and ELOC), SOCS1 or WSB1 and CUL5. Part of a multisubunit ubiquitin ligase complex consisting of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5 (By similarity). Interacts directly with CUL1 and probably also with CUL2, CUL3, CUL4A, CUL4B, CUL5 and CUL7. Interacts with CDC34. Interacts with GLMN. GLMN competes for the binding site of the E2 ubiquitin- conjugating enzyme CDC34 and disrupts CDC34 binding. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Part of a SCF complex consisting of CUL1, FBXO3, RBX1 and SKP1; this complex interacts with PML via FBXO3. Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 and CCNF. Identified in a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex together with HINT1 and CDC34 (By similarity). Component of multiple BCR (BTB-CUL3-RBX1) E3 ubiquitin- protein ligase complexes formed of CUL3, RBX1 and a variable BTB domain-containing protein. Part of the BCR(ENC1) complex containing ENC1. Part of the BCR(GAN) complex containing GAN. Part of the BCR(KLHL41) complex containing KLHL41. Part of the BCR(KEAP1) complex containing KEAP1 (By similarity). Interacts with SESN1 and SESN2 (By similarity). Interacts with NOTCH2 (By similarity). Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1 (By similarity). Interacts with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5 (By similarity). Component of a BCR3 (BTB- CUL3-RBX1) E3 ubiquitin ligase complex, also named Cul3-RING ubiquitin ligase complex CUL3(KBTBD6/7), composed of CUL3, RBX1, KBTBD6 and KBTBD7 (By similarity). Component of the ECS(LRR1) complex with the substrate recognition component LRR1 (PubMed:33590678). P62878; P58004: SESN2; Xeno; NbExp=3; IntAct=EBI-2507414, EBI-3939642; Widely expressed (PubMed:10643962). Expressed in oocytes (at protein level) (PubMed:24357321). Expressed at high levels in zygotes and at lower levels in germinal vesicle (GV) stage oocytes and MII-stage oocytes. Expression strongly decreases from 2-cell stage to blastula. The RING-type zinc finger domain is essential for ubiquitin ligase activity (By similarity). It coordinates an additional third zinc ion (PubMed:22118460). Belongs to the RING-box family. ubiquitin ligase complex ubiquitin-protein transferase activity protein binding nucleus nucleoplasm anaphase-promoting complex cytoplasm cytosol DNA repair ubiquitin-dependent protein catabolic process protein monoubiquitination cellular response to DNA damage stimulus transcription factor binding eukaryotic initiation factor 4E binding zinc ion binding protein ubiquitination transferase activity SCF ubiquitin ligase complex NEDD8 transferase activity protein catabolic process VCB complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process cullin-RING ubiquitin ligase complex Cul2-RING ubiquitin ligase complex Cul3-RING ubiquitin ligase complex Cul4A-RING E3 ubiquitin ligase complex Cul4B-RING E3 ubiquitin ligase complex Cul5-RING ubiquitin ligase complex Cul7-RING ubiquitin ligase complex ubiquitin protein ligase binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-ubiquitin ligase activity proteasome-mediated ubiquitin-dependent protein catabolic process nuclear SCF ubiquitin ligase complex macromolecular complex binding protein neddylation metal ion binding ubiquitin protein ligase activity Cul4-RING E3 ubiquitin ligase complex cullin family protein binding uc007wwq.1 uc007wwq.2 uc007wwq.3 
ENSMUST00000023040.9 Slc25a17 ENSMUST00000023040.9 solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17 (from RefSeq NM_011399.3) ENSMUST00000023040.1 ENSMUST00000023040.2 ENSMUST00000023040.3 ENSMUST00000023040.4 ENSMUST00000023040.5 ENSMUST00000023040.6 ENSMUST00000023040.7 ENSMUST00000023040.8 NM_011399 O70579 PM34_MOUSE Pmp34 Pmp35 uc007wwk.1 uc007wwk.2 uc007wwk.3 Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Reaction=AMP(out) + CoA(in) = AMP(in) + CoA(out); Xref=Rhea:RHEA:73095, ChEBI:CHEBI:57287, ChEBI:CHEBI:456215; Evidence=; Reaction=3'-dephospho-CoA(in) + AMP(out) = 3'-dephospho-CoA(out) + AMP(in); Xref=Rhea:RHEA:73099, ChEBI:CHEBI:57328, ChEBI:CHEBI:456215; Evidence=; Reaction=acetyl-CoA(in) + AMP(out) = acetyl-CoA(out) + AMP(in); Xref=Rhea:RHEA:73447, ChEBI:CHEBI:57288, ChEBI:CHEBI:456215; Evidence=; Reaction=AMP(in) + NAD(+)(out) = AMP(out) + NAD(+)(in); Xref=Rhea:RHEA:65424, ChEBI:CHEBI:57540, ChEBI:CHEBI:456215; Evidence=; Reaction=AMP(out) + FAD(in) = AMP(in) + FAD(out); Xref=Rhea:RHEA:73087, ChEBI:CHEBI:57692, ChEBI:CHEBI:456215; Evidence=; Reaction=AMP(out) + FMN(in) = AMP(in) + FMN(out); Xref=Rhea:RHEA:73091, ChEBI:CHEBI:58210, ChEBI:CHEBI:456215; Evidence=; Reaction=ADP(out) + AMP(in) = ADP(in) + AMP(out); Xref=Rhea:RHEA:72851, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; Evidence=; Reaction=adenosine 3',5'-bisphosphate(in) + AMP(out) = adenosine 3',5'- bisphosphate(out) + AMP(in); Xref=Rhea:RHEA:73451, ChEBI:CHEBI:58343, ChEBI:CHEBI:456215; Evidence=; Reaction=CoA(out) + FAD(in) = CoA(in) + FAD(out); Xref=Rhea:RHEA:73143, ChEBI:CHEBI:57287, ChEBI:CHEBI:57692; Evidence=; Reaction=adenosine 3',5'-bisphosphate(out) + FAD(in) = adenosine 3',5'- bisphosphate(in) + FAD(out); Xref=Rhea:RHEA:73147, ChEBI:CHEBI:57692, ChEBI:CHEBI:58343; Evidence=; Reaction=CoA(out) + FMN(in) = CoA(in) + FMN(out); Xref=Rhea:RHEA:73151, ChEBI:CHEBI:57287, ChEBI:CHEBI:58210; Evidence=; Reaction=adenosine 3',5'-bisphosphate(out) + FMN(in) = adenosine 3',5'- bisphosphate(in) + FMN(out); Xref=Rhea:RHEA:73155, ChEBI:CHEBI:58210, ChEBI:CHEBI:58343; Evidence=; Reaction=FAD(out) + NAD(+)(in) = FAD(in) + NAD(+)(out); Xref=Rhea:RHEA:73163, ChEBI:CHEBI:57540, ChEBI:CHEBI:57692; Evidence=; Reaction=FMN(out) + NAD(+)(in) = FMN(in) + NAD(+)(out); Xref=Rhea:RHEA:73159, ChEBI:CHEBI:57540, ChEBI:CHEBI:58210; Evidence=; Reaction=CoA(out) + NAD(+)(in) = CoA(in) + NAD(+)(out); Xref=Rhea:RHEA:73167, ChEBI:CHEBI:57287, ChEBI:CHEBI:57540; Evidence=; Reaction=adenosine 3',5'-bisphosphate(out) + NAD(+)(in) = adenosine 3',5'-bisphosphate(in) + NAD(+)(out); Xref=Rhea:RHEA:73171, ChEBI:CHEBI:57540, ChEBI:CHEBI:58343; Evidence=; Reaction=ADP(in) + FMN(out) = ADP(out) + FMN(in); Xref=Rhea:RHEA:73175, ChEBI:CHEBI:58210, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(in) + FAD(out) = ADP(out) + FAD(in); Xref=Rhea:RHEA:73183, ChEBI:CHEBI:57692, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(out) + CoA(in) = ADP(in) + CoA(out); Xref=Rhea:RHEA:72839, ChEBI:CHEBI:57287, ChEBI:CHEBI:456216; Evidence=; Reaction=adenosine 3',5'-bisphosphate(in) + ADP(out) = adenosine 3',5'- bisphosphate(out) + ADP(in); Xref=Rhea:RHEA:72847, ChEBI:CHEBI:58343, ChEBI:CHEBI:456216; Evidence=; Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the newly synthesized SLC25A17 in the cytosol. Cytoplasm Peroxisome membrane ; Multi-pass membrane protein Expressed in liver, kidney, heart, spleen, muscle and lung. The N- and C-terminal portions are exposed to the cytoplasm. Lacks a typical peroxisomal sorting signal. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity. Belongs to the mitochondrial carrier (TC 2.A.29) family. ATP transmembrane transporter activity cytoplasm mitochondrion peroxisome peroxisomal membrane integral component of peroxisomal membrane fatty acid beta-oxidation ADP transmembrane transporter activity coenzyme A transmembrane transporter activity FAD transmembrane transporter activity ADP transport ATP transport fatty acid transport membrane integral component of membrane transmembrane transporter activity coenzyme A transmembrane transport FAD transmembrane transport NAD transmembrane transport NAD transport FMN transmembrane transporter activity chaperone binding NAD transporter activity transmembrane transport AMP transport AMP transmembrane transporter activity uc007wwk.1 uc007wwk.2 uc007wwk.3 
ENSMUST00000023043.10 Adsl ENSMUST00000023043.10 adenylosuccinate lyase (from RefSeq NM_009634.6) Adl ENSMUST00000023043.1 ENSMUST00000023043.2 ENSMUST00000023043.3 ENSMUST00000023043.4 ENSMUST00000023043.5 ENSMUST00000023043.6 ENSMUST00000023043.7 ENSMUST00000023043.8 ENSMUST00000023043.9 NM_009634 P54822 PUR8_MOUSE Q8VCD4 uc007wvz.1 uc007wvz.2 uc007wvz.3 uc007wvz.4 This gene encodes a protein that is involved in adenosine monophosphate (AMP) biosynthesis and maintaining AMP levels in the muscle. The encoded enzyme catalyzes the release of fumarate during AMP biosynthesis by cleaving the substrates succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide (AICA) ribotide, and adenylosuccinate to give adenylate. In humans, this gene is associated with adenylosuccinate deficiency, a rare autosomal disorder resulting in a spectrum of neurological symptoms. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Jan 2013]. ##Evidence-Data-START## Transcript exon combination :: AK049372.1, AK168906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. Reaction=N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate; Xref=Rhea:RHEA:16853, ChEBI:CHEBI:29806, ChEBI:CHEBI:57567, ChEBI:CHEBI:456215; EC=4.3.2.2; Evidence=; Reaction=(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4- carboxamido]succinate = 5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide + fumarate; Xref=Rhea:RHEA:23920, ChEBI:CHEBI:29806, ChEBI:CHEBI:58443, ChEBI:CHEBI:58475; EC=4.3.2.2; Evidence=; Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2. Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2. Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. response to hypoxia catalytic activity N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity mitochondrion cytosol purine nucleotide metabolic process purine nucleotide biosynthetic process AMP biosynthetic process 'de novo' IMP biosynthetic process response to nutrient aerobic respiration purine ribonucleotide biosynthetic process ribonucleoside monophosphate biosynthetic process response to muscle activity lyase activity response to starvation 'de novo' AMP biosynthetic process protein tetramerization (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity uc007wvz.1 uc007wvz.2 uc007wvz.3 uc007wvz.4 
ENSMUST00000023044.7 Fam83f ENSMUST00000023044.7 family with sequence similarity 83, member F, transcript variant 1 (from RefSeq NM_145986.3) A0A0R4J033 A0A0R4J033_MOUSE ENSMUST00000023044.1 ENSMUST00000023044.2 ENSMUST00000023044.3 ENSMUST00000023044.4 ENSMUST00000023044.5 ENSMUST00000023044.6 Fam83f NM_145986 uc007wvr.1 uc007wvr.2 Belongs to the FAM83 family. uc007wvr.1 uc007wvr.2 
ENSMUST00000023048.12 Mief1 ENSMUST00000023048.12 mitochondrial elongation factor 1, transcript variant 2 (from RefSeq NM_178719.6) ENSMUST00000023048.1 ENSMUST00000023048.10 ENSMUST00000023048.11 ENSMUST00000023048.2 ENSMUST00000023048.3 ENSMUST00000023048.4 ENSMUST00000023048.5 ENSMUST00000023048.6 ENSMUST00000023048.7 ENSMUST00000023048.8 ENSMUST00000023048.9 MID51_MOUSE Mid51 NM_178719 Q8BGV8 Q8C4Y9 Smcr7l uc007wvi.1 uc007wvi.2 uc007wvi.3 uc007wvi.4 Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. Homodimer. Interacts with DNM1L. Q8BGV8; Q8K1M6: Dnm1l; NbExp=2; IntAct=EBI-16092561, EBI-2365792; Q8BGV8; Q8K1M6-3: Dnm1l; NbExp=5; IntAct=EBI-16092561, EBI-16092613; Q8BGV8; Q8BGV8: Mief1; NbExp=2; IntAct=EBI-16092561, EBI-16092561; Mitochondrion outer membrane ; Single-pass membrane protein Belongs to the MID49/MID51 family. nucleotide binding mitochondrial fission protein binding mitochondrion mitochondrial outer membrane mitochondrial matrix membrane integral component of membrane GDP binding identical protein binding ADP binding positive regulation of mitochondrial translation cellular response to hypoxia positive regulation of mitochondrial fission positive regulation of protein targeting to membrane mitochondrial large ribosomal subunit uc007wvi.1 uc007wvi.2 uc007wvi.3 uc007wvi.4 
ENSMUST00000023050.9 Tab1 ENSMUST00000023050.9 TGF-beta activated kinase 1/MAP3K7 binding protein 1 (from RefSeq NM_025609.3) ENSMUST00000023050.1 ENSMUST00000023050.2 ENSMUST00000023050.3 ENSMUST00000023050.4 ENSMUST00000023050.5 ENSMUST00000023050.6 ENSMUST00000023050.7 ENSMUST00000023050.8 Map3k7ip1 NM_025609 Q7TQJ5 Q80V65 Q8CF89 Q8R0D1 TAB1_MOUSE uc007wve.1 uc007wve.2 uc007wve.3 Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:12464436, PubMed:28073917). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation. Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:24037507). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism. Plays also a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (By similarity). Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Interacts with TRAF6 and MAPK14; these interactions allow MAPK14 autophosphorylation. Q8CF89; P53349: Map3k1; NbExp=4; IntAct=EBI-1778503, EBI-447913; Q8CF89; Q62073: Map3k7; NbExp=2; IntAct=EBI-1778503, EBI-1775345; Q8CF89; Q86Y07-1: VRK2; Xeno; NbExp=2; IntAct=EBI-1778503, EBI-1207633; Phosphorylated at all three sites Ser-421, Thr-429 and Ser-436 by MAPK14 when cells were exposed to cellular stresses, or stimulated with TNF-alpha, IL1 or LPS. These phosphorylations inhibit TAK1 activation by a feedback control mechanism. Dephosphorylated by DUSP14 at Ser-436, leading to TAB1-MAP3K7/TAK1 complex inactivation in T-cells. Ubiquitinated by MAP3K1 with 'Lys-63'-linked polyubiquitin; leading to activation of TAK1 and of JNK and p38 MAP kinases following EGF and TGF-beta stimulation. Ubiquitinated by ITCH with 'Lys-48'- linked polyubiquitin; leading to proteasomal degradation (By similarity). Ubiquitinated by RNF114 during maternal-to-zygotic transition; leading to degradation (PubMed:28073917). O-GlcNAcylated at Ser-393 is required for full MAP3K7/TAK1 activation upon stimulation with IL-1 or osmotic stress. Mutant mice die in the late stages of gestation, exhibiting edema and severe embryonic hemorrhage. Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity. activation of MAPKKK activity in utero embryonic development heart morphogenesis cardiac septum development catalytic activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity protein binding nucleus cytosol protein dephosphorylation transforming growth factor beta receptor signaling pathway nuclear speck kinase activator activity lung development macromolecular complex aorta development positive regulation of MAP kinase activity macromolecular complex binding mitogen-activated protein kinase p38 binding coronary vasculature development uc007wve.1 uc007wve.2 uc007wve.3 
ENSMUST00000023057.10 Nptxr ENSMUST00000023057.10 neuronal pentraxin receptor (from RefSeq NM_030689.4) A0A9R1SP20 A0A9R1SP20_MOUSE ENSMUST00000023057.1 ENSMUST00000023057.2 ENSMUST00000023057.3 ENSMUST00000023057.4 ENSMUST00000023057.5 ENSMUST00000023057.6 ENSMUST00000023057.7 ENSMUST00000023057.8 ENSMUST00000023057.9 NM_030689 Nptxr uc007wul.1 uc007wul.2 uc007wul.3 uc007wul.4 This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058962.1, AK147605.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Lacks conserved residue(s) required for the propagation of feature annotation. uc007wul.1 uc007wul.2 uc007wul.3 uc007wul.4 
ENSMUST00000023059.13 Dscc1 ENSMUST00000023059.13 DNA replication and sister chromatid cohesion 1, transcript variant 2 (from RefSeq NM_183089.3) DCC1 DCC1_MOUSE DSCC1 ENSMUST00000023059.1 ENSMUST00000023059.10 ENSMUST00000023059.11 ENSMUST00000023059.12 ENSMUST00000023059.2 ENSMUST00000023059.3 ENSMUST00000023059.4 ENSMUST00000023059.5 ENSMUST00000023059.6 ENSMUST00000023059.7 ENSMUST00000023059.8 ENSMUST00000023059.9 NM_183089 Q14AI0 Q4FZL5 uc007vrw.1 uc007vrw.2 uc007vrw.3 Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity). Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex. Interacts with CTF8 and CTF18. Interacts with DDX11. Nucleus Belongs to the DCC1 family. chromosome, centromeric region chromatin DNA binding DNA clamp loader activity nucleus nucleoplasm DNA replication regulation of DNA replication cell cycle mitotic sister chromatid cohesion single-stranded DNA-dependent ATP-dependent DNA helicase activity Ctf18 RFC-like complex DNA duplex unwinding maintenance of mitotic sister chromatid cohesion post-translational protein acetylation positive regulation of DNA-directed DNA polymerase activity uc007vrw.1 uc007vrw.2 uc007vrw.3 
ENSMUST00000023060.13 Npcd ENSMUST00000023060.13 neuronal pentraxin chromo domain, transcript variant 1 (from RefSeq NM_001013360.2) ENSMUST00000023060.1 ENSMUST00000023060.10 ENSMUST00000023060.11 ENSMUST00000023060.12 ENSMUST00000023060.2 ENSMUST00000023060.3 ENSMUST00000023060.4 ENSMUST00000023060.5 ENSMUST00000023060.6 ENSMUST00000023060.7 ENSMUST00000023060.8 ENSMUST00000023060.9 H3BLN6 H3BLN6_MOUSE NM_001013360 Npcd uc007wun.1 uc007wun.2 uc007wun.3 This gene encodes multiple cytoplasmic proteins composed of a neuronal pentraxin domain linked to a chromo domain. These isoforms are expressed in numerous regions of the central nervous system, where they are present in distinct subcellular arrangements in different brain regions. This gene may play a role in neuronal differentiation. [provided by RefSeq, Jul 2008]. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Lacks conserved residue(s) required for the propagation of feature annotation. nucleus cytoplasm cytosol cytoplasmic side of plasma membrane protein domain specific binding filopodium dendrite growth cone neuronal cell body uc007wun.1 uc007wun.2 uc007wun.3 
ENSMUST00000023061.7 Josd1 ENSMUST00000023061.7 Josephin domain containing 1 (from RefSeq NM_028792.3) ENSMUST00000023061.1 ENSMUST00000023061.2 ENSMUST00000023061.3 ENSMUST00000023061.4 ENSMUST00000023061.5 ENSMUST00000023061.6 JOS1_MOUSE NM_028792 Q3U3E9 Q9DBJ6 uc007wue.1 uc007wue.2 uc007wue.3 uc007wue.4 Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly- ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Interacts with beta-actin/ACTB. Cell membrane Cytoplasm Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding. Widely expressed (at protein level). Monoubiquitinated. Ubiquitination activates deubiquitination activity in vitro. thiol-dependent ubiquitin-specific protease activity cellular_component cytoplasm plasma membrane proteolysis peptidase activity membrane protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity uc007wue.1 uc007wue.2 uc007wue.3 uc007wue.4 
ENSMUST00000023062.5 Tomm22 ENSMUST00000023062.5 translocase of outer mitochondrial membrane 22 (from RefSeq NM_172609.3) ENSMUST00000023062.1 ENSMUST00000023062.2 ENSMUST00000023062.3 ENSMUST00000023062.4 NM_172609 Q543M4 Q9CPQ3 Q9D8D3 TOM22_MOUSE Tom22 uc007wud.1 uc007wud.2 uc007wud.3 Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity). Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with PPP2R2B and TOMM40 (By similarity). Mitochondrion outer membrane ; Single-pass membrane protein The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins. Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C- tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). Belongs to the Tom22 family. protein binding mitochondrion mitochondrial outer membrane mitochondrial outer membrane translocase complex mitochondrial inner membrane protein targeting to mitochondrion intracellular protein transport protein transmembrane transporter activity protein transport membrane integral component of membrane positive regulation of apoptotic process protein import into mitochondrial outer membrane protein insertion into mitochondrial membrane protein transmembrane transport uc007wud.1 uc007wud.2 uc007wud.3 
ENSMUST00000023064.9 Cby1 ENSMUST00000023064.9 chibby family member 1, beta catenin antagonist, transcript variant 1 (from RefSeq NM_028634.4) CBY1_MOUSE Cby ENSMUST00000023064.1 ENSMUST00000023064.2 ENSMUST00000023064.3 ENSMUST00000023064.4 ENSMUST00000023064.5 ENSMUST00000023064.6 ENSMUST00000023064.7 ENSMUST00000023064.8 NM_028634 Pgea1 Q9D1C2 uc007wuc.1 uc007wuc.2 uc007wuc.3 Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of CTNNB1. Interacts (C-terminus) with TCIM (C-terminus), TCIM competes with CTNNB1 for the interaction with CBY1. Interacts with FAM92A; this interaction facilitates targeting of FAM92A to cilium basal body. Interacts with CIBAR2. Nucleus speckle Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Golgi apparatus Golgi apparatus, trans-Golgi network Found in heart, brain, lung, liver, muscle, kidney and testis. Levels are approximately 3-fold higher in embryonic and adult heart than in lung or liver. Ubiquitously expressed in early stages of embryonic stem cell differentiation but decreases at later stages when high expression is restricted to cardiomyocytes. 'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies. Belongs to the chibby family. nucleus cytoplasm Golgi apparatus trans-Golgi network centriole cytoskeleton beta-catenin binding protein localization nuclear speck cell projection organization cell differentiation negative regulation of Wnt signaling pathway ciliary basal body identical protein binding protein homodimerization activity cell projection fat cell differentiation negative regulation of transcription, DNA-templated protein homotetramerization cardiac muscle cell differentiation cilium assembly negative regulation of canonical Wnt signaling pathway ciliary transition zone assembly uc007wuc.1 uc007wuc.2 uc007wuc.3 
ENSMUST00000023065.8 Dmc1 ENSMUST00000023065.8 DNA meiotic recombinase 1, transcript variant 1 (from RefSeq NM_010059.3) DMC1_MOUSE Dmc1 Dmc1h ENSMUST00000023065.1 ENSMUST00000023065.2 ENSMUST00000023065.3 ENSMUST00000023065.4 ENSMUST00000023065.5 ENSMUST00000023065.6 ENSMUST00000023065.7 Lim15 NM_010059 Q61880 uc007wtu.1 uc007wtu.2 uc007wtu.3 uc007wtu.4 uc007wtu.5 This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. In mouse, deficiency of this gene causes infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]. Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Double stacked ring-shaped homooctamer (By similarity). Interacts with BRCA2 (By similarity). Interacts with the MND1-PSMC3IP heterodimer (PubMed:15834424). Interacts with RAD51AP1; the interaction is direct and stimulates DMC1-mediated homologous recombination (By similarity). Nucleus Chromosome Testis. In spermatocytes, shows punctate localization along chromosome axes specifically in early meiotic prophase I cells. Foci start to appear from the leptotene stage, reach their greatest number in the zygotene stage, in the early pachytene stage, the DMC1 foci mostly disappeared from autosomes and became restricted to the sex chromosomes. Belongs to the RecA family. DMC1 subfamily. recombinase activity nucleotide binding DNA recombinase assembly chromosome, telomeric region condensed nuclear chromosome ovarian follicle development oocyte maturation DNA binding double-stranded DNA binding single-stranded DNA binding ATP binding nucleus nucleoplasm chromosome DNA metabolic process DNA repair mitotic recombination cell cycle synapsis reciprocal meiotic recombination male meiosis I gamete generation spermatogenesis spermatid development DNA-dependent ATPase activity ATPase activity strand invasion meiotic cell cycle uc007wtu.1 uc007wtu.2 uc007wtu.3 uc007wtu.4 uc007wtu.5 
ENSMUST00000023067.4 Ribc2 ENSMUST00000023067.4 RIB43A domain with coiled-coils 2, transcript variant 3 (from RefSeq NR_164346.1) ENSMUST00000023067.1 ENSMUST00000023067.2 ENSMUST00000023067.3 G3X8W0 NR_164346 Q9D4Q1 RIBC2_MOUSE Ribc2 uc007xcz.1 uc007xcz.2 uc007xcz.3 uc007xcz.4 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Cytoplasm, cytoskeleton, cilium axoneme Belongs to the RIB43A family. Sequence=AAI12374.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB30190.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function biological_process uc007xcz.1 uc007xcz.2 uc007xcz.3 uc007xcz.4 
ENSMUST00000023068.8 Smc1b ENSMUST00000023068.8 structural maintenance of chromosomes 1B (from RefSeq NM_080470.1) ENSMUST00000023068.1 ENSMUST00000023068.2 ENSMUST00000023068.3 ENSMUST00000023068.4 ENSMUST00000023068.5 ENSMUST00000023068.6 ENSMUST00000023068.7 NM_080470 Q920F6 SMC1B_MOUSE Smc1l2 uc007xcx.1 uc007xcx.2 uc007xcx.3 Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Forms a heterodimer with SMC3. Component of a meiosis-specific cohesin complex, probably composed of the SMC1B and SMC3 heterodimer attached via their SMC hinge domain, RAD21 (or its meiosis-specific related protein REC8), which link them, and STAG3, which interacts with RAD21 or REC8. The cohesin complex interacts with the cohesin loading complex subunits NIPBL/Scc2 (via HEAT repeats) and MAU2/Scc4. NIPBL directly contacts all members of the complex, RAD21, SMC1A/B, SMC3 and STAG1 (By similarity). Nucleus Chromosome Chromosome, centromere Note=Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation. Spermatocytes (at protein level). Testis and ovary specific. Not expressed in somatic cells. The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 or REC8 protein, forming a ring structure (By similarity). Belongs to the SMC family. SMC1 subfamily. nucleotide binding chromosome, centromeric region condensed nuclear chromosome synaptonemal complex lateral element DNA binding protein binding ATP binding nucleus nucleoplasm chromosome cytosol cell cycle sister chromatid cohesion meiotic cohesin complex nuclear meiotic cohesin complex chromosome organization meiotic cell cycle uc007xcx.1 uc007xcx.2 uc007xcx.3 
ENSMUST00000023069.9 Fam118a ENSMUST00000023069.9 family with sequence similarity 118, member A, transcript variant 12 (from RefSeq NR_166140.1) ENSMUST00000023069.1 ENSMUST00000023069.2 ENSMUST00000023069.3 ENSMUST00000023069.4 ENSMUST00000023069.5 ENSMUST00000023069.6 ENSMUST00000023069.7 ENSMUST00000023069.8 F118A_MOUSE NR_166140 Q3UP97 Q8C4H6 Q8C5E1 Q91YN1 uc007xcv.1 uc007xcv.2 uc007xcv.3 uc007xcv.4 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91YN1-1; Sequence=Displayed; Name=2; IsoId=Q91YN1-2; Sequence=VSP_014460, VSP_014461; Belongs to the FAM118 family. cellular_component biological_process membrane integral component of membrane identical protein binding uc007xcv.1 uc007xcv.2 uc007xcv.3 uc007xcv.4 
ENSMUST00000023070.7 Upk3a ENSMUST00000023070.7 uroplakin 3A (from RefSeq NM_023478.2) ENSMUST00000023070.1 ENSMUST00000023070.2 ENSMUST00000023070.3 ENSMUST00000023070.4 ENSMUST00000023070.5 ENSMUST00000023070.6 NM_023478 Q27QV3 Q9JKX8 UPK3A_MOUSE Upk3 uc007xcs.1 uc007xcs.2 uc007xcs.3 uc007xcs.4 Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). Heterodimer with uroplakin-1B (UPK1B). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). Belongs to the uroplakin-3 family. cell morphogenesis kidney development protein binding endoplasmic reticulum endoplasmic reticulum membrane water transport urea transport membrane integral component of membrane apical plasma membrane epithelial cell differentiation potassium ion homeostasis sodium ion homeostasis urinary bladder development uc007xcs.1 uc007xcs.2 uc007xcs.3 uc007xcs.4 
ENSMUST00000023071.8 Samm50 ENSMUST00000023071.8 SAMM50 sorting and assembly machinery component (from RefSeq NM_178614.5) ENSMUST00000023071.1 ENSMUST00000023071.2 ENSMUST00000023071.3 ENSMUST00000023071.4 ENSMUST00000023071.5 ENSMUST00000023071.6 ENSMUST00000023071.7 NM_178614 Q3TIL3 Q3TTG7 Q3TWD3 Q8BGH2 SAM50_MOUSE uc007xbx.1 uc007xbx.2 uc007xbx.3 Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex (By similarity). The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (By similarity). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex (By similarity). Interacts with IMMT/MIC60 (By similarity). Interacts with CHCHD3/MIC19 (PubMed:21081504). Interacts with ARMC1 (By similarity). (Microbial infection) Interacts with parasite T.gondii RH strain MAF1b1; the interaction is probably indirect and results in the disruption of the MIB complex and the formation of SPOTs (structures positive for outer mitochondrial membrane (OMM)), a cellular response to OMM stress, which leads to the constitutive shedding of OMM vesicles. Mitochondrion outer membrane ; Multi-pass membrane protein Cytoplasm Mitochondrion Its C-terminal part seems to contain many membrane-spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure. Belongs to the SAM50/omp85 family. mitochondrial sorting and assembly machinery complex protein binding cytoplasm mitochondrion mitochondrial outer membrane mitochondrial inner membrane membrane integral component of membrane outer membrane mitochondrial respiratory chain complex assembly cellular macromolecular complex assembly cristae formation protein import into mitochondrial outer membrane uc007xbx.1 uc007xbx.2 uc007xbx.3 
ENSMUST00000023072.7 Parvb ENSMUST00000023072.7 parvin, beta (from RefSeq NM_133167.3) ENSMUST00000023072.1 ENSMUST00000023072.2 ENSMUST00000023072.3 ENSMUST00000023072.4 ENSMUST00000023072.5 ENSMUST00000023072.6 NM_133167 PARVB_MOUSE Q9ES46 uc007xby.1 uc007xby.2 uc007xby.3 Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration (By similarity). Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin (By similarity). Interacts with DYSF. Q9ES46; Q9ES28: Arhgef7; NbExp=2; IntAct=EBI-6914996, EBI-642580; Q9ES46; Q64691: Capn3; NbExp=3; IntAct=EBI-6914996, EBI-21927513; Q9ES46; O55222: Ilk; NbExp=3; IntAct=EBI-6914996, EBI-6690138; Cell junction, focal adhesion. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Cell projection, lamellipodium Cytoplasm, myofibril, sarcomere Cytoplasm, myofibril, sarcomere, Z line Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia (By similarity). Expressed predominantly in heart and moderately in spleen, lung and skeletal muscle. Phosphorylated by ILK. Belongs to the parvin family. actin binding protein binding cytoplasm cytoskeleton plasma membrane focal adhesion cell adhesion establishment or maintenance of cell polarity actin cytoskeleton membrane sarcomere Z disc lamellipodium cell projection assembly lamellipodium assembly cell junction actin cytoskeleton reorganization substrate adhesion-dependent cell spreading cell projection establishment or maintenance of cell polarity regulating cell shape uc007xby.1 uc007xby.2 uc007xby.3 
ENSMUST00000023074.9 Parvg ENSMUST00000023074.9 parvin, gamma, transcript variant 2 (from RefSeq NM_022321.4) ENSMUST00000023074.1 ENSMUST00000023074.2 ENSMUST00000023074.3 ENSMUST00000023074.4 ENSMUST00000023074.5 ENSMUST00000023074.6 ENSMUST00000023074.7 ENSMUST00000023074.8 NM_022321 PARVG_MOUSE Q8BH45 Q91X89 Q9ERD8 uc007xbz.1 uc007xbz.2 uc007xbz.3 uc007xbz.4 Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Interacts with integrin-linked protein kinase and actin. Cell junction, focal adhesion. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Note=Constituent of focal adhesions. Expressed strongly in spleen and testis, moderately in lung and weakly in brain and heart. Belongs to the parvin family. actin binding cytoplasm cytoskeleton plasma membrane focal adhesion cell adhesion establishment or maintenance of cell polarity actin cytoskeleton membrane cell projection assembly cell junction actin cytoskeleton reorganization substrate adhesion-dependent cell spreading uc007xbz.1 uc007xbz.2 uc007xbz.3 uc007xbz.4 
ENSMUST00000023075.9 C1qtnf6 ENSMUST00000023075.9 C1q and tumor necrosis factor related protein 6, transcript variant 1 (from RefSeq NM_028331.5) C1QT6_MOUSE ENSMUST00000023075.1 ENSMUST00000023075.2 ENSMUST00000023075.3 ENSMUST00000023075.4 ENSMUST00000023075.5 ENSMUST00000023075.6 ENSMUST00000023075.7 ENSMUST00000023075.8 NM_028331 Q6IR41 Q8BKR0 uc007wpn.1 uc007wpn.2 uc007wpn.3 uc007wpn.4 Secreted protein binding extracellular region collagen trimer extracellular space macromolecular complex identical protein binding uc007wpn.1 uc007wpn.2 uc007wpn.3 uc007wpn.4 
ENSMUST00000023083.9 Cyp2d22 ENSMUST00000023083.9 cytochrome P450, family 2, subfamily d, polypeptide 22, transcript variant 2 (from RefSeq NM_019823.4) Cyp2d22 ENSMUST00000023083.1 ENSMUST00000023083.2 ENSMUST00000023083.3 ENSMUST00000023083.4 ENSMUST00000023083.5 ENSMUST00000023083.6 ENSMUST00000023083.7 ENSMUST00000023083.8 NM_019823 Q9JKY7 Q9JKY7_MOUSE uc007wze.1 uc007wze.2 uc007wze.3 uc007wze.4 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane Microsome membrane Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process serotonin biosynthetic process from tryptophan xenobiotic metabolic process female pregnancy C21-steroid hormone metabolic process arachidonic acid monooxygenase activity steroid hydroxylase activity response to organic substance membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen drug metabolic process arachidonic acid metabolic process heme binding dopamine biosynthetic process dopamine metabolic process exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc007wze.1 uc007wze.2 uc007wze.3 uc007wze.4 
ENSMUST00000023085.7 Ndufa6 ENSMUST00000023085.7 NADH:ubiquinone oxidoreductase subunit A6 (from RefSeq NM_025987.4) ENSMUST00000023085.1 ENSMUST00000023085.2 ENSMUST00000023085.3 ENSMUST00000023085.4 ENSMUST00000023085.5 ENSMUST00000023085.6 NDUA6_MOUSE NM_025987 Ndufa6 Q9CQZ5 uc007wzc.1 uc007wzc.2 uc007wzc.3 uc007wzc.4 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Mammalian complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the complex I LYR family. molecular_function mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I response to oxidative stress membrane mitochondrial membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc007wzc.1 uc007wzc.2 uc007wzc.3 uc007wzc.4 
ENSMUST00000023086.15 Smdt1 ENSMUST00000023086.15 single-pass membrane protein with aspartate rich tail 1 (from RefSeq NM_026914.1) EMRE_MOUSE ENSMUST00000023086.1 ENSMUST00000023086.10 ENSMUST00000023086.11 ENSMUST00000023086.12 ENSMUST00000023086.13 ENSMUST00000023086.14 ENSMUST00000023086.2 ENSMUST00000023086.3 ENSMUST00000023086.4 ENSMUST00000023086.5 ENSMUST00000023086.6 ENSMUST00000023086.7 ENSMUST00000023086.8 ENSMUST00000023086.9 Emre NM_026914 Q58EA5 Q9DB10 Smdt1 uc007wzb.1 uc007wzb.2 uc007wzb.3 Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:27001609). Required to bridge the calcium- sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (By similarity). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1 (By similarity). Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct (PubMed:27001609). Interacts (via the poly- Asp region) with MICU1 (via polybasic region); the interaction is direct (By similarity). Interacts (via its C-terminal poly-Asp tail) with MCUR1; the interaction is direct (By similarity). Unprocessed form interacts (via transit peptide) with MAIP1 (By similarity). Mitochondrion inner membrane ; Single-pass membrane protein Note=MAIP1 is required to assist sorting of EMRE/SMDT1 into mitochondrion by protecting EMRE/SMDT1 against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). Widely expressed. The GXXXX[G/A/S] motif at the C-terminal part of the transmembrane region mediates interaction with MCU and is required to activate the calcium-conducting pore in the uniporter complex. The poly-Asp region at the C-terminus mediates interaction with the polybasic region of MICU1. Undergoes proteolytic degradation in neurons: degraded by AFG3L2 before SMDT1/EMRE assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU. Belongs to the SMDT1/EMRE family. Sequence=AAH92006.1; Type=Frameshift; Evidence=; molecular_function nucleus mitochondrion mitochondrial inner membrane ion transport calcium ion transport mitochondrial calcium ion transport membrane integral component of membrane integral component of mitochondrial inner membrane mitochondrial calcium uptake mitochondrial calcium ion homeostasis uniplex complex uc007wzb.1 uc007wzb.2 uc007wzb.3 
ENSMUST00000023087.13 Twf1 ENSMUST00000023087.13 twinfilin actin binding protein 1, transcript variant 1 (from RefSeq NM_008971.5) ENSMUST00000023087.1 ENSMUST00000023087.10 ENSMUST00000023087.11 ENSMUST00000023087.12 ENSMUST00000023087.2 ENSMUST00000023087.3 ENSMUST00000023087.4 ENSMUST00000023087.5 ENSMUST00000023087.6 ENSMUST00000023087.7 ENSMUST00000023087.8 ENSMUST00000023087.9 NM_008971 O09132 Ptk9 Q52L77 Q80X09 Q91YR1 TWF1_MOUSE uc007xjl.1 uc007xjl.2 uc007xjl.3 Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. Interacts with G-actin; ADP-actin form and capping protein (CP) (PubMed:12807912, PubMed:15282541, PubMed:16511569). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2 (PubMed:12807912). When bound to PI(4,5)P2, it is down-regulated (PubMed:12807912). Interacts with ACTG1 (By similarity). Q91YR1; P68135: ACTA1; Xeno; NbExp=2; IntAct=EBI-527441, EBI-367540; Cytoplasm Cytoplasm, cytoskeleton Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts. Widely expressed with highest levels in brain, liver and kidney. Also expressed in heart, lung and testis. Not detected in spleen or skeletal muscle. Expression was widespread throughout the embryonic stages analyzed; 10.5 dpc, 12.5 dpc, 14.5 dpc and 18.5 dpc. At 14.5 dpc, strongest expression was observed in the developing central and peripheral nervous system (CNS and PNS, respectively) and in the olfactory sensory epithelium. In the CNS, the proliferating neuronal precursors in the ventricular zone expressed it more than the postmitotic neurons. At 18.5 dpc, highest expression levels were detected in the mechanosensory hair cells of the inner ear and in the differentiated keratinocytes of the skin. Phosphorylated on serine and threonine residues. Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. Name=Protein Spotlight; Note=Molecular embrace - Issue 73 of August 2006; URL="https://web.expasy.org/spotlight/back_issues/073"; actin binding actin monomer binding protein tyrosine kinase activity protein binding ATP binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm cytosol cytoskeleton actin filament cell-cell junction regulation of lamellipodium assembly positive regulation of cardiac muscle hypertrophy positive regulation of neuron projection development actin cytoskeleton peptidyl-tyrosine phosphorylation myofibril actin filament depolymerization filopodium negative regulation of actin filament polymerization sequestering of actin monomers regulation of actin phosphorylation macromolecular complex binding perinuclear region of cytoplasm actin filament binding barbed-end actin filament capping ruffle membrane uc007xjl.1 uc007xjl.2 uc007xjl.3 
ENSMUST00000023088.8 Naga ENSMUST00000023088.8 N-acetyl galactosaminidase, alpha, transcript variant 7 (from RefSeq NR_177253.1) ENSMUST00000023088.1 ENSMUST00000023088.2 ENSMUST00000023088.3 ENSMUST00000023088.4 ENSMUST00000023088.5 ENSMUST00000023088.6 ENSMUST00000023088.7 NAGAB_MOUSE NR_177253 O88620 Q8R437 Q8VDK2 Q9QWR8 uc007wyw.1 uc007wyw.2 uc007wyw.3 Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids. Reaction=Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids.; EC=3.2.1.49; Reaction=a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc- nLc4Cer(d18:1(4E)) + H2O = a neolactoside IV(2)-alpha-Fuc- nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine; Xref=Rhea:RHEA:48212, ChEBI:CHEBI:15377, ChEBI:CHEBI:28471, ChEBI:CHEBI:28691, ChEBI:CHEBI:40356; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48213; Evidence=; Reaction=a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc- nLc4Cer(d18:0) + H2O = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine; Xref=Rhea:RHEA:49304, ChEBI:CHEBI:15377, ChEBI:CHEBI:40356, ChEBI:CHEBI:91118, ChEBI:CHEBI:91119; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49305; Evidence=; Reaction=a globoside IV3GalNAc-Gb4Cer + H2O = a globoside Gb4Cer + N- acetyl-alpha-D-galactosamine; Xref=Rhea:RHEA:48412, ChEBI:CHEBI:15377, ChEBI:CHEBI:40356, ChEBI:CHEBI:88167, ChEBI:CHEBI:90400; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48413; Evidence=; Homodimer. Lysosome Belongs to the glycosyl hydrolase 27 family. Sequence=AAL87527.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; catalytic activity hydrolase activity, hydrolyzing O-glycosyl compounds alpha-galactosidase activity cytoplasm lysosome carbohydrate metabolic process metabolic process alpha-N-acetylgalactosaminidase activity oligosaccharide metabolic process carbohydrate catabolic process glycoside catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds glycolipid catabolic process protein homodimerization activity glycosylceramide catabolic process uc007wyw.1 uc007wyw.2 uc007wyw.3 
ENSMUST00000023089.5 Wbp2nl ENSMUST00000023089.5 WBP2 N-terminal like (from RefSeq NM_029066.1) ENSMUST00000023089.1 ENSMUST00000023089.2 ENSMUST00000023089.3 ENSMUST00000023089.4 NM_029066 Pawp Q9D529 WBP2L_MOUSE uc007wyv.1 uc007wyv.2 uc007wyv.3 May play a role in meiotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization. Expressed in testis. transcription coactivator activity nucleus egg activation chromatin DNA binding perinuclear theca female pronucleus assembly male pronucleus assembly sperm flagellum WW domain binding positive regulation of nucleic acid-templated transcription uc007wyv.1 uc007wyv.2 uc007wyv.3 
ENSMUST00000023095.14 Septin3 ENSMUST00000023095.14 septin 3, transcript variant 9 (from RefSeq NM_001368647.1) ENSMUST00000023095.1 ENSMUST00000023095.10 ENSMUST00000023095.11 ENSMUST00000023095.12 ENSMUST00000023095.13 ENSMUST00000023095.2 ENSMUST00000023095.3 ENSMUST00000023095.4 ENSMUST00000023095.5 ENSMUST00000023095.6 ENSMUST00000023095.7 ENSMUST00000023095.8 ENSMUST00000023095.9 NM_001368647 Q3TNZ2 Q7TNT7 Q9Z1S5 SEPT3_MOUSE Sep3 Sept3 Septin3 uc007wyt.1 uc007wyt.2 uc007wyt.3 Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Cytoplasm. Cytoplasm, cytoskeleton Synapse Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z1S5-1; Sequence=Displayed; Name=2; IsoId=Q9Z1S5-2; Sequence=VSP_025400; Expressed in the brain including the cerebrum, hippocampus and cerebellum (at protein level). Expressed in the cerebral cortex from 13.5 dpc to P30, expression peaks at P15. Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity). Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. Sequence=AAD02884.1; Type=Frameshift; Evidence=; nucleotide binding GTPase activity protein binding GTP binding cytoplasm cytosol cytoskeleton septin ring cell cycle microtubule cytoskeleton cell junction septin complex presynaptic membrane identical protein binding neuron projection synapse cell division cytoskeleton-dependent cytokinesis presynapse presynaptic cytoskeleton uc007wyt.1 uc007wyt.2 uc007wyt.3 
ENSMUST00000023099.8 Slc38a2 ENSMUST00000023099.8 solute carrier family 38, member 2, transcript variant 1 (from RefSeq NM_175121.4) Ata2 ENSMUST00000023099.1 ENSMUST00000023099.2 ENSMUST00000023099.3 ENSMUST00000023099.4 ENSMUST00000023099.5 ENSMUST00000023099.6 ENSMUST00000023099.7 Kiaa1382 NM_175121 Q3TEX3 Q6PFR1 Q6ZPS7 Q810U9 Q8CC66 Q8CD21 Q8CFE6 S38A2_MOUSE Sat2 Slc38a2 Snat2 uc007xkm.1 uc007xkm.2 uc007xkm.3 Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:34406367). The trasnport is pH-sensitive, Li(+)- intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (By similarity). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (PubMed:16365304). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (PubMed:34406367). Reaction=L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out); Xref=Rhea:RHEA:29283, ChEBI:CHEBI:29101, ChEBI:CHEBI:57972; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29285; Evidence=; Reaction=glycine(in) + Na(+)(in) = glycine(out) + Na(+)(out); Xref=Rhea:RHEA:68228, ChEBI:CHEBI:29101, ChEBI:CHEBI:57305; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68230; Evidence=; Reaction=L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out); Xref=Rhea:RHEA:29575, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29577; Evidence=; Reaction=L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out); Xref=Rhea:RHEA:28967, ChEBI:CHEBI:29101, ChEBI:CHEBI:60039; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28969; Evidence=; Reaction=L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out); Xref=Rhea:RHEA:68240, ChEBI:CHEBI:29101, ChEBI:CHEBI:57844; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68242; Evidence=; Reaction=L-histidine(in) + Na(+)(in) = L-histidine(out) + Na(+)(out); Xref=Rhea:RHEA:71583, ChEBI:CHEBI:29101, ChEBI:CHEBI:57595; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71585; Evidence=; Reaction=L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out); Xref=Rhea:RHEA:71383, ChEBI:CHEBI:29101, ChEBI:CHEBI:58048; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71385; Evidence=; Reaction=L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out); Xref=Rhea:RHEA:68236, ChEBI:CHEBI:29101, ChEBI:CHEBI:58359; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68238; Evidence=; Reaction=L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out); Xref=Rhea:RHEA:69999, ChEBI:CHEBI:29101, ChEBI:CHEBI:57926; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70001; Evidence=; Reaction=L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out); Xref=Rhea:RHEA:29263, ChEBI:CHEBI:29101, ChEBI:CHEBI:57427; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29265; Evidence=; Reaction=L-phenylalanine(in) + Na(+)(in) = L-phenylalanine(out) + Na(+)(out); Xref=Rhea:RHEA:68244, ChEBI:CHEBI:29101, ChEBI:CHEBI:58095; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68246; Evidence=; Inhibited by N-methyl-D-glucamine. Inhibited by choline. Allosteric regulation of sodium ions binding by pH. Cell membrane ulti-pass membrane protein Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (PubMed:17050538). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal (By similarity). Expressed in cerebral and cerebellar astrocytes and neurons. The extracellular C-terminal domain controls the voltage dependence for amino acid transports activity. Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. Placenta-specific Slc38a2 knockdown reduced fetal weight by 11% at the end of gestation. Belongs to the amino acid/polyamine transporter 2 family. Sequence=BAC98152.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; amino acid transmembrane transport plasma membrane integral component of plasma membrane brush border ion transport sodium ion transport amino acid transport glutamine transport female pregnancy amino acid transmembrane transporter activity L-glutamine transmembrane transporter activity symporter activity membrane integral component of membrane cerebral cortex development axon dendrite glycine betaine transport alanine transport cellular response to amino acid starvation sarcolemma neuronal cell body cellular response to mechanical stimulus uc007xkm.1 uc007xkm.2 uc007xkm.3 
ENSMUST00000023100.8 Srebf2 ENSMUST00000023100.8 sterol regulatory element binding factor 2, transcript variant 1 (from RefSeq NM_033218.2) ENSMUST00000023100.1 ENSMUST00000023100.2 ENSMUST00000023100.3 ENSMUST00000023100.4 ENSMUST00000023100.5 ENSMUST00000023100.6 ENSMUST00000023100.7 NM_033218 Q3U1N2 Q925C2 Q9ESZ4 SRBP2_MOUSE Srebf2 Srebp2 uc007wyi.1 uc007wyi.2 uc007wyi.3 [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element- binding protein 2), which is embedded in the endoplasmic reticulum membrane (By similarity). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:9616204, PubMed:16100574). [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:9616204). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:9616204). Activation by cleavage is down-regulated upon activation of SIRT3-dependent PRKAA1/AMPK-alpha signaling cascade which leads to inhibition of ATP-consuming lipogenesis to restore cellular energy balance. [Sterol regulatory element-binding protein 2]: Forms a tight complex with SCAP, the SCAP-SREBP complex, in the endoplasmic reticulum membrane. Interacts (via C-terminal domain) with RNF139. [Processed sterol regulatory element-binding protein 2]: Homodimer; efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein (PubMed:11283257). Interacts with LMNA (PubMed:11929849). Q3U1N2; Q9JM73: Srf; NbExp=3; IntAct=EBI-645275, EBI-493266; Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasmic vesicle, COPII- coated vesicle membrane ; Multi-pass membrane protein Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum (By similarity). Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed (By similarity). [Processed sterol regulatory element-binding protein 2]: Nucleus Note=Transported into the nucleus with the help of importin-beta (PubMed:10397761, PubMed:11283257). Dimerization of the bHLH domain is a prerequisite for importin beta-dependent nuclear import (PubMed:10397761, PubMed:11283257). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U1N2-1; Sequence=Displayed; Name=2; IsoId=Q3U1N2-2; Sequence=VSP_052658, VSP_052659; [Sterol regulatory element-binding protein 2]: Processed in the Golgi apparatus, releasing the protein from the membrane. At low cholesterol the SCAP-SREBP complex is recruited into COPII vesicles for export from the endoplasmic reticulum. In the Golgi, complex SREBPs are cleaved sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain, releasing the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7. Cleavage and activation is induced by mediated cholesterol efflux. Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. [Processed sterol regulatory element-binding protein 2]: Ubiquitinated; the nuclear form has a rapid turnover and is rapidly ubiquitinated and degraded by the proteasome in the nucleus. Death around embryonic day 7-8. Belongs to the SREBP family. negative regulation of transcription from RNA polymerase II promoter Golgi membrane RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus regulation of transcription, DNA-templated lipid metabolic process protein C-terminus binding steroid metabolic process cholesterol metabolic process cellular response to starvation response to hormone positive regulation of cholesterol storage ER to Golgi transport vesicle membrane membrane integral component of membrane dendrite cytoplasmic vesicle SREBP-SCAP-Insig complex response to lipid cholesterol homeostasis intracellular membrane-bounded organelle sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity E-box binding cellular response to low-density lipoprotein particle stimulus regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter negative regulation of cholesterol efflux positive regulation of pri-miRNA transcription from RNA polymerase II promoter uc007wyi.1 uc007wyi.2 uc007wyi.3 
ENSMUST00000023101.10 Slc38a4 ENSMUST00000023101.10 solute carrier family 38, member 4, transcript variant 4 (from RefSeq NM_027052.3) Ata3 ENSMUST00000023101.1 ENSMUST00000023101.2 ENSMUST00000023101.3 ENSMUST00000023101.4 ENSMUST00000023101.5 ENSMUST00000023101.6 ENSMUST00000023101.7 ENSMUST00000023101.8 ENSMUST00000023101.9 NM_027052 Nat3 Q3TEZ9 Q3TJ89 Q3TPL5 Q8R1S9 Q8VIE7 S38A4_MOUSE Slc38a4 Snat4 uc007xkr.1 uc007xkr.2 Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:12537539, PubMed:23451088, PubMed:23301202). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:12537539). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L- proline and L-glutamine and L-methionine (By similarity). Reaction=L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out); Xref=Rhea:RHEA:29283, ChEBI:CHEBI:29101, ChEBI:CHEBI:57972; Evidence= PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29285; Evidence=; Reaction=L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out); Xref=Rhea:RHEA:68240, ChEBI:CHEBI:29101, ChEBI:CHEBI:57844; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68242; Evidence=; Reaction=L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out); Xref=Rhea:RHEA:71383, ChEBI:CHEBI:29101, ChEBI:CHEBI:58048; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71385; Evidence=; Reaction=L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out); Xref=Rhea:RHEA:69999, ChEBI:CHEBI:29101, ChEBI:CHEBI:57926; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70001; Evidence=; Reaction=L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out); Xref=Rhea:RHEA:29575, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29577; Evidence=; Reaction=glycine(in) + Na(+)(in) = glycine(out) + Na(+)(out); Xref=Rhea:RHEA:68228, ChEBI:CHEBI:29101, ChEBI:CHEBI:57305; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68230; Evidence=; Reaction=L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out); Xref=Rhea:RHEA:68236, ChEBI:CHEBI:29101, ChEBI:CHEBI:58359; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68238; Evidence=; Reaction=L-histidine(in) + Na(+)(in) = L-histidine(out) + Na(+)(out); Xref=Rhea:RHEA:71583, ChEBI:CHEBI:29101, ChEBI:CHEBI:57595; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71585; Evidence=; Reaction=L-cysteine(in) + Na(+)(in) = L-cysteine(out) + Na(+)(out); Xref=Rhea:RHEA:68232, ChEBI:CHEBI:29101, ChEBI:CHEBI:35235; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68234; Evidence=; Reaction=L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out); Xref=Rhea:RHEA:28967, ChEBI:CHEBI:29101, ChEBI:CHEBI:60039; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28969; Evidence=; Kinetic parameters: KM=1.6 mM for L-alanine ; KM=0.3 mM for L-alanine ; pH dependence: Optimum pH is 7.5-8.5. ; Cell membrane ulti-pass membrane protein Cell projection, microvillus membrane ; Multi-pass membrane protein Note=Microvillus membrane localization in placenta. Detected in liver, in hepatocytes surrounding the central vein (PubMed:12537539, PubMed:31570606). Not detected in heart, kidney, brain, lung, small intestine, spleen and thymus (PubMed:12537539). Highly expressed in placenta (PubMed:31570606). Up-regulated by insulin. The disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell surface. Heterozygous mice pups for SLC38A4 die shortly after birth, and only 28% of pups survive to 2 weeks. Heterozygous mice pups have a significantly reduced body and placental weight when the allele is paternally inherited while mice exhibit normal body and placental weight when the allele is inherited maternally. Imprinted gene expressed from the paternal allele in blastocysts. Belongs to the amino acid/polyamine transporter 2 family. There is a disagreement about sodium-independent transport of cationic amino acids, such as L-arginine and L-lysine (By similarity). While Padmanabhan et al (PubMed:23451088) shown that SLC38A4 may mediate sodium-independent transport of cationic amino acids, such as L-arginine (PubMed:23451088). Recent studies by Fairweather et al., using quantitative LC-MS analysis, shown any transport activity of cationic amino acids, such as L-arginine and L-lysine (By similarity). Sequence=BAE37721.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; amino acid transmembrane transport plasma membrane integral component of plasma membrane ion transport sodium ion transport amino acid transport amino acid transmembrane transporter activity symporter activity membrane integral component of membrane uc007xkr.1 uc007xkr.2 
ENSMUST00000023104.7 Rpap3 ENSMUST00000023104.7 RNA polymerase II associated protein 3 (from RefSeq NM_028003.2) D15Ertd682e ENSMUST00000023104.1 ENSMUST00000023104.2 ENSMUST00000023104.3 ENSMUST00000023104.4 ENSMUST00000023104.5 ENSMUST00000023104.6 NM_028003 Q9D706 RPAP3_MOUSE uc007xkv.1 uc007xkv.2 uc007xkv.3 Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Tightly associated with the RNA polymerase II complex (By similarity). Component of the R2TP complex composed at least of RUVBL1, RUVBL2, RPAP3 and PIHD1 (By similarity). Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92 (By similarity). Interacts with PIH1D1 (By similarity). Interacts with TSC1 and TSC2 (By similarity). Interacts with PRPF8 and EFTUD2 in a ZNHIT2-dependent manner (By similarity). Belongs to the RPAP3 family. molecular_function cytosol biological_process R2TP complex uc007xkv.1 uc007xkv.2 uc007xkv.3 
ENSMUST00000023112.12 Pmm1 ENSMUST00000023112.12 phosphomannomutase 1, transcript variant 1 (from RefSeq NM_013872.4) ENSMUST00000023112.1 ENSMUST00000023112.10 ENSMUST00000023112.11 ENSMUST00000023112.2 ENSMUST00000023112.3 ENSMUST00000023112.4 ENSMUST00000023112.5 ENSMUST00000023112.6 ENSMUST00000023112.7 ENSMUST00000023112.8 ENSMUST00000023112.9 NM_013872 Pmm1 Q545Q8 Q545Q8_MOUSE uc007wxt.1 uc007wxt.2 uc007wxt.3 uc007wxt.4 uc007wxt.5 Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. Reaction=alpha-D-mannose 1-phosphate = D-mannose 6-phosphate; Xref=Rhea:RHEA:11140, ChEBI:CHEBI:58409, ChEBI:CHEBI:58735; EC=5.4.2.8; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2. Homodimer. Cytoplasm Belongs to the eukaryotic PMM family. phosphomannomutase activity cytoplasm mannose metabolic process GDP-mannose biosynthetic process isomerase activity uc007wxt.1 uc007wxt.2 uc007wxt.3 uc007wxt.4 uc007wxt.5 
ENSMUST00000023113.7 Polr3h ENSMUST00000023113.7 polymerase (RNA) III (DNA directed) polypeptide H (from RefSeq NM_030229.4) ENSMUST00000023113.1 ENSMUST00000023113.2 ENSMUST00000023113.3 ENSMUST00000023113.4 ENSMUST00000023113.5 ENSMUST00000023113.6 NM_030229 Q91XE5 Q9D2C6 RPC8_MOUSE uc007wxr.1 uc007wxr.2 uc007wxr.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity). Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3- POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Interacts with CRCP/RPC9. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex. Nucleus Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family. immune system process DNA binding DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm DNA-directed RNA polymerase III complex centrosome nucleobase-containing compound metabolic process transcription, DNA-templated transcription from RNA polymerase III promoter transcription initiation from RNA polymerase III promoter intracellular membrane-bounded organelle innate immune response defense response to virus RNA polymerase III activity uc007wxr.1 uc007wxr.2 uc007wxr.3 
ENSMUST00000023116.7 Aco2 ENSMUST00000023116.7 aconitase 2, mitochondrial (from RefSeq NM_080633.2) ACON_MOUSE ENSMUST00000023116.1 ENSMUST00000023116.2 ENSMUST00000023116.3 ENSMUST00000023116.4 ENSMUST00000023116.5 ENSMUST00000023116.6 NM_080633 Q3UDK9 Q3ULG9 Q3UNH7 Q505P4 Q99KI0 uc007wxp.1 uc007wxp.2 uc007wxp.3 Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. Reaction=citrate = D-threo-isocitrate; Xref=Rhea:RHEA:10336, ChEBI:CHEBI:15562, ChEBI:CHEBI:16947; EC=4.2.1.3; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster per subunit. Binding of a [3Fe-4S] cluster leads to an inactive enzyme. ; Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. Monomer. Mitochondrion Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers. Belongs to the aconitase/IPM isomerase family. liver development aconitate hydratase activity iron ion binding mitochondrion cytosol tricarboxylic acid cycle citrate metabolic process isocitrate metabolic process lyase activity response to isolation stress myelin sheath metal ion binding iron-sulfur cluster binding 3 iron, 4 sulfur cluster binding 4 iron, 4 sulfur cluster binding uc007wxp.1 uc007wxp.2 uc007wxp.3 
ENSMUST00000023117.10 Phf5a ENSMUST00000023117.10 PHD finger protein 5A (from RefSeq NM_026737.3) ENSMUST00000023117.1 ENSMUST00000023117.2 ENSMUST00000023117.3 ENSMUST00000023117.4 ENSMUST00000023117.5 ENSMUST00000023117.6 ENSMUST00000023117.7 ENSMUST00000023117.8 ENSMUST00000023117.9 NM_026737 P83870 PHF5A_MOUSE Q3TQX7 Q9UH06 uc007wxo.1 uc007wxo.2 uc007wxo.3 Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (By similarity). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (By similarity). Within the 17S U2 SnRNP complex, PHF5A is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (By similarity). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Also involved in elongation by RNA polymerase II as part of the PAF1 complex (PAF1C) (PubMed:27749823). PAF1C is required for maintenance of embryonic stem cell (ESC) self-renewal and cellular reprogramming of stem cells (PubMed:27749823). Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes (PubMed:27749823). Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes (PubMed:27749823). Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies (PubMed:27749823). Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (PubMed:27749823). Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (By similarity). Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins (By similarity). Part of the SF3B subcomplex of the 17S U2 SnRNP complex (By similarity). SF3B associates with the splicing subcomplex SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Within the SF3B complex interacts directly with SF3B1 and SF3B3 (By similarity). Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with CRIPT (By similarity). Interacts (via N- terminus) with U2AF1 and SRSF5; acts to bridge the two (PubMed:18758164). Interacts (via C-terminus) with EP400 and DDX1; acts to bridge the two (PubMed:18758164). Interacts with the PAF1 complex (PAF1C) composed of CDC73, PAF1, LEO1, CTR9, RTF1 and SKIC8 (PubMed:27749823). Within the PAF1C interacts directly with CDC73 and SKIC8 (PubMed:27749823). Interacts with RNA polymerase II (PubMed:27749823). Nucleus cleus speckle Expressed in primary spermatocytes (at protein level) (PubMed:18758164). Ubiquitously expressed in pre- and postnatal tissues (PubMed:12054543). Highly expressed in pluripotent embryonic stem cells (ESCs) (at protein level) and induced pluripotent stem cells (iPSCs) (PubMed:27749823). Expression levels are down-regulated following differentiation in embryonic stem cells (ESCs) and in differentiated mouse embryonic fibroblasts (MEFs). Belongs to the PHF5 family. mRNA splicing, via spliceosome DNA binding transcription factor activity, sequence-specific DNA binding RNA binding protein binding nucleus nucleoplasm spliceosomal complex U2 snRNP U12-type spliceosomal complex mRNA processing RNA splicing nuclear matrix nuclear speck positive regulation of transcription, DNA-templated metal ion binding U2-type precatalytic spliceosome nucleolus uc007wxo.1 uc007wxo.2 uc007wxo.3 
ENSMUST00000023119.15 Vdr ENSMUST00000023119.15 vitamin D (1,25-dihydroxyvitamin D3) receptor (from RefSeq NM_009504.4) ENSMUST00000023119.1 ENSMUST00000023119.10 ENSMUST00000023119.11 ENSMUST00000023119.12 ENSMUST00000023119.13 ENSMUST00000023119.14 ENSMUST00000023119.2 ENSMUST00000023119.3 ENSMUST00000023119.4 ENSMUST00000023119.5 ENSMUST00000023119.6 ENSMUST00000023119.7 ENSMUST00000023119.8 ENSMUST00000023119.9 NM_009504 Nr1i1 P48281 Q922X0 VDR_MOUSE uc007xlk.1 uc007xlk.2 uc007xlk.3 Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (PubMed:32354638). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (PubMed:12016314, PubMed:32354638). Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with the corepressor NCOR1. Interacts with SNW1. Interacts with IRX4, the interaction does not affect its transactivation activity (By similarity). Interacts with CRY1 (PubMed:28751364). Interacts with CRY2 in a ligand-dependent manner (PubMed:28751364). P48281; Q925T6: Grip1; NbExp=2; IntAct=EBI-346797, EBI-537752; P48281; Q64337: Sqstm1; NbExp=3; IntAct=EBI-346797, EBI-645025; P48281; Q00403: GTF2B; Xeno; NbExp=2; IntAct=EBI-346797, EBI-389564; P48281; Q9Y6Q9: NCOA3; Xeno; NbExp=2; IntAct=EBI-346797, EBI-81196; P48281; Q13573: SNW1; Xeno; NbExp=2; IntAct=EBI-346797, EBI-632715; Nucleus toplasm Note=Localizes mainly to the nucleus. Translocated into the nucleus via both ligand-dependent and ligand- independent pathways; ligand-independent nuclear translocation is mediated by IPO4. By 1,25-dihydroxyvitamin D(3) in kidney. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Belongs to the nuclear hormone receptor family. NR1 subfamily. negative regulation of transcription from RNA polymerase II promoter euchromatin heterochromatin cell morphogenesis transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding skeletal system development dense fibrillar component DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding vitamin D binding protein binding nucleus nucleoplasm nuclear heterochromatin cytoplasm cytosol regulation of transcription, DNA-templated lipid metabolic process calcium ion transport cellular calcium ion homeostasis multicellular organism development lactation transcription factor binding zinc ion binding negative regulation of cell proliferation animal organ morphogenesis positive regulation of gene expression negative regulation of keratinocyte proliferation positive regulation of vitamin D 24-hydroxylase activity nuclear matrix cell differentiation T-tubule ligand-dependent nuclear receptor transcription coactivator activity signaling receptor activity bile acid signaling pathway lithocholic acid receptor activity cholesterol homeostasis intracellular membrane-bounded organelle receptor complex steroid hormone mediated signaling pathway sequence-specific DNA binding positive regulation of keratinocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter decidualization metal ion binding retinoid X receptor binding perinuclear region of cytoplasm intestinal absorption regulation of calcium ion transport lipid homeostasis positive regulation of apoptotic process involved in mammary gland involution regulation of calcidiol 1-monooxygenase activity mammary gland branching involved in pregnancy vitamin D receptor signaling pathway vitamin D response element binding cellular response to lipopolysaccharide RNA polymerase II transcription factor complex apoptotic signaling pathway calcitriol binding lithocholic acid binding caveola uc007xlk.1 uc007xlk.2 uc007xlk.3 
ENSMUST00000023123.15 Col2a1 ENSMUST00000023123.15 collagen, type II, alpha 1, transcript variant 3 (from RefSeq NR_177066.1) CO2A1_MOUSE Col2a1 ENSMUST00000023123.1 ENSMUST00000023123.10 ENSMUST00000023123.11 ENSMUST00000023123.12 ENSMUST00000023123.13 ENSMUST00000023123.14 ENSMUST00000023123.2 ENSMUST00000023123.3 ENSMUST00000023123.4 ENSMUST00000023123.5 ENSMUST00000023123.6 ENSMUST00000023123.7 ENSMUST00000023123.8 ENSMUST00000023123.9 NR_177066 P28481 Q61428 Q62031 Q62032 Q62033 Q641K3 Q6LDB1 Q6LDI8 Q6LDI9 Q80VY3 Q80X38 Q8CEF7 Q8K0N6 uc007xlp.1 uc007xlp.2 uc007xlp.3 uc007xlp.4 Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Homotrimers of alpha 1(II) chains. P28481; P28481: Col2a1; NbExp=2; IntAct=EBI-738477, EBI-738477; Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=P28481-3; Sequence=Displayed; Name=2; Synonyms=Long; IsoId=P28481-1; Sequence=VSP_022782; Name=3; Synonyms=Short; IsoId=P28481-2; Sequence=VSP_022780, VSP_022782; Name=4; IsoId=P28481-4; Sequence=VSP_022781, VSP_022784; Name=5; IsoId=P28481-5; Sequence=VSP_022783, VSP_022785; Name=6; IsoId=P28481-6; Sequence=VSP_022781, VSP_022785; Name=7; IsoId=P28481-7; Sequence=VSP_022780; Expressed in chondrogenic tissues in advance of chondrocyte differentiation. Expressed early in embryogenesis at 9.5 days both in the cranial mesenchyme destined for the chondrocranium, and the sclerotome of the somites, and at 12.5 days in the primordia of the hyoid and the laryngeal cartilage. Detected in all the chondrogenic tissues of the axial and appendicular skeleton until the onset of endochondral ossification. Expression also observed in non-chondrogenic tissues such as the notochord. Also expressed much later in the tail tendon, at 16.5-18.5 days. Transiently expressed in the heart at 9.5- 12.5 days, the epidermis at 10.5-14.5 days, the calvarial mesenchyme at 12.5-16.5 days, the inner ear at 14.5 days and the fetal brain from 9.5-14.5 days. Within the neural tube, expression is localized to the proliferative ventricular cells of the forebrain and midbrain of 9.5- 10.5 day embryos, and subsequently, restricted to the rhombencephalic basal plate, the ventricular layer of the hindbrain and the cervical spinal cord. The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity). Contains mostly 4-hydroxyproline. Prolines at the third position of the tripeptide repeating unit (G-X-P) are 4-hydroxylated in some or all of the chains. Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline. Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains. O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide. Note=Defects in Col2a1 are the cause of a phenotype resembling human spondyloepiphyseal dysplasia congenita (sedc). Homozygous sedc mice can be identified at birth by their small size and shortened trunk. Adults have shortened noses, dysplastic vertebrae, femora and tibias, and retinoschisis and hearing loss. Belongs to the fibrillar collagen family. Sequence=BAC25865.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; skeletal system development cartilage condensation ossification tissue homeostasis endochondral ossification chondrocyte differentiation heart morphogenesis extracellular matrix structural constituent extracellular region collagen trimer collagen type II trimer basement membrane extracellular space cytoplasm proteoglycan metabolic process central nervous system development visual perception sensory perception of sound regulation of gene expression extracellular matrix structural constituent conferring tensile strength extracellular matrix organization collagen fibril organization notochord development extracellular matrix limb morphogenesis MHC class II protein binding inner ear morphogenesis identical protein binding proteoglycan binding metal ion binding platelet-derived growth factor binding skeletal system morphogenesis inner ear development cartilage development palate development limb bud formation embryonic skeletal joint morphogenesis bone development cartilage development involved in endochondral bone morphogenesis otic vesicle development cellular response to BMP stimulus anterior head development negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc007xlp.1 uc007xlp.2 uc007xlp.3 uc007xlp.4 
ENSMUST00000023128.8 Itga5 ENSMUST00000023128.8 integrin alpha 5 (fibronectin receptor alpha), transcript variant 1 (from RefSeq NM_010577.4) E9QN40 ENSMUST00000023128.1 ENSMUST00000023128.2 ENSMUST00000023128.3 ENSMUST00000023128.4 ENSMUST00000023128.5 ENSMUST00000023128.6 ENSMUST00000023128.7 ITA5_MOUSE NM_010577 P11688 uc007xyb.1 uc007xyb.2 uc007xyb.3 uc007xyb.4 uc007xyb.5 uc007xyb.6 The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain, which is proteolytically processed to generate light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signaling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen (PubMed:36812915). It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (By similarity). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. ITGA5/Alpha-5 associates with ITGB1/beta-1 (By similarity). Interacts with NISCH (PubMed:11121431, PubMed:14535848, PubMed:15229651). Interacts with HPS5 (By similarity). Interacts with RAB21 and COMP. Interacts with CIB1 (By similarity). ITGA5:ITGB1 interacts with CCN3 (By similarity). ITGA5:ITGB1 interacts with FBN1 (By similarity). ITGA5:ITGB1 interacts with IL1B (By similarity). ITGA5:ITGB1 interacts with ACE2 (By similarity). Interacts with ANGPT2 (By similarity). P11688; P68254: Ywhaq; NbExp=2; IntAct=EBI-6477055, EBI-400675; Cell membrane ; Single-pass type I membrane protein Cell junction, focal adhesion Proteolytic cleavage by PCSK5 mediates activation of the precursor. Mice die at 10-11 dpc. They show both extraembryonic and embryonic vascular defects, and severe abnormalities in the development of the posterior trunk (PubMed:7508365). Liver- specific mutants show defects specifically in exercise-induced autophagy, but not fasting-induced autophagy, in the liver. Metabolically, after regular diet feeding and 3 weeks of high fat diet (HFD) feeding without exercise, mutants and control mice show comparable body weight gain, glucose tolerance and insulin tolerance. After HFD feeding and daily exercise, they show comparable body weight, exercise endurance and tissue weight. Daily exercise training doesnt't improve glucose tolerance, insulin tolerance and hepatic insulin signaling as it does in control mice (PubMed:36812915). Belongs to the integrin alpha chain family. epidermal growth factor receptor binding integrin binding protein binding cytoplasm endoplasmic reticulum Golgi apparatus plasma membrane cell-cell junction focal adhesion cell-substrate junction assembly cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion integrin-mediated signaling pathway female pregnancy memory integrin complex external side of plasma membrane cell surface positive regulation of cell-substrate adhesion membrane integral component of membrane cell junction positive regulation of cell migration cytoplasmic vesicle cell-substrate adhesion ruffle membrane cell adhesion mediated by integrin cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion wound healing, spreading of epidermal cells endodermal cell differentiation synapse regulation of angiogenesis metal ion binding positive regulation of peptidyl-tyrosine phosphorylation cell adhesion molecule binding positive regulation of sprouting angiogenesis negative regulation of anoikis uc007xyb.1 uc007xyb.2 uc007xyb.3 uc007xyb.4 uc007xyb.5 uc007xyb.6 
ENSMUST00000023129.15 Gtsf1 ENSMUST00000023129.15 gametocyte specific factor 1 (from RefSeq NM_028797.1) Cue110 ENSMUST00000023129.1 ENSMUST00000023129.10 ENSMUST00000023129.11 ENSMUST00000023129.12 ENSMUST00000023129.13 ENSMUST00000023129.14 ENSMUST00000023129.2 ENSMUST00000023129.3 ENSMUST00000023129.4 ENSMUST00000023129.5 ENSMUST00000023129.6 ENSMUST00000023129.7 ENSMUST00000023129.8 ENSMUST00000023129.9 Fam112b GTSF1_MOUSE Gtsf1 NM_028797 Q9DAN6 uc007xyd.1 uc007xyd.2 uc007xyd.3 uc007xyd.4 uc007xyd.5 Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells. Cytoplasm Expressed abundantly in adult testis, at moderate levels in unfertilized eggs and ovaries and weakly in embryonic stem cells. In the male gonad, barely detected at 13.5 dpc or at birth, detected weakly on postnatal day 14 and maximally expressed in the 4- or 7-week-old mouse testis but not detected in the epididymis of the 7-week-old mouse (at protein level). In the female gonad, low levels detected at birth (at protein level). In the adult testis, present predominantly in pachytene spermatocytes and round spermatids but not in spermatogonia, preleptotene spermatocytes or elongating spermatids (at protein level). Mutant mice grow normally and appear healthy but males are sterile due to massive germ cell apoptotic death after postnatal day 14 with meiocytes ceasing meiotic progression before the early meitoic phase. There is also increased transcription of LINE-1 and IAP retrotransposons accompanied by demethylation of their promoter regions. Belongs to the UPF0224 (FAM112) family. cytoplasm spermatogenesis cell differentiation metal ion binding uc007xyd.1 uc007xyd.2 uc007xyd.3 uc007xyd.4 uc007xyd.5 
ENSMUST00000023132.5 Pde1b ENSMUST00000023132.5 phosphodiesterase 1B, Ca2+-calmodulin dependent, transcript variant 1 (from RefSeq NM_008800.2) ENSMUST00000023132.1 ENSMUST00000023132.2 ENSMUST00000023132.3 ENSMUST00000023132.4 NM_008800 O35384 PDE1B_MOUSE Pde1b Pde1b1 Q01065 uc007xyh.1 uc007xyh.2 uc007xyh.3 uc007xyh.4 Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. Reaction=a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'- phosphate + H(+); Xref=Rhea:RHEA:14653, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57867, ChEBI:CHEBI:58464; EC=3.1.4.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14654; Evidence=; Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, ChEBI:CHEBI:58115; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16958; Evidence=; Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions. ; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 2 has a preference for magnesium ions. ; Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+). Homodimer. Cytoplasm, cytosol Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. regulation of neurotransmitter levels response to amphetamine cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity calmodulin-dependent cyclic-nucleotide phosphodiesterase activity calmodulin binding cytoplasm signal transduction locomotory behavior phosphoric diester hydrolase activity visual learning hydrolase activity monocyte differentiation cellular response to macrophage colony-stimulating factor stimulus regulation of dopamine metabolic process serotonin metabolic process neuronal cell body metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity cellular response to granulocyte macrophage colony-stimulating factor stimulus uc007xyh.1 uc007xyh.2 uc007xyh.3 uc007xyh.4 
ENSMUST00000023133.8 Ppp1r1a ENSMUST00000023133.8 protein phosphatase 1, regulatory inhibitor subunit 1A (from RefSeq NM_021391.3) ENSMUST00000023133.1 ENSMUST00000023133.2 ENSMUST00000023133.3 ENSMUST00000023133.4 ENSMUST00000023133.5 ENSMUST00000023133.6 ENSMUST00000023133.7 NM_021391 PPR1A_MOUSE Q9ERT9 uc007xyj.1 uc007xyj.2 uc007xyj.3 Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. Interacts with PPP1R15A. Phosphorylation of Thr-35 is required for activity. Belongs to the protein phosphatase inhibitor 1 family. protein phosphatase inhibitor activity protein binding extracellular space cytoplasm carbohydrate metabolic process glycogen metabolic process signal transduction negative regulation of phosphoprotein phosphatase activity intracellular signal transduction uc007xyj.1 uc007xyj.2 uc007xyj.3 
ENSMUST00000023134.5 Glycam1 ENSMUST00000023134.5 glycosylation dependent cell adhesion molecule 1, transcript variant 2 (from RefSeq NM_008134.3) A6H6D0 ENSMUST00000023134.1 ENSMUST00000023134.2 ENSMUST00000023134.3 ENSMUST00000023134.4 GLCM1_MOUSE NM_008134 Q02596 uc007xyk.1 uc007xyk.2 uc007xyk.3 uc007xyk.4 uc007xyk.5 Adhesion molecule that accomplishes cell binding by presenting carbohydrate(s) to the lectin domain of L-selectin. Cell membrane. Lymph nodes. Associated with the lumenal surface of the high endothelial venules of peripheral lymph nodes. Extensively O-glycosylated. Belongs to the PP3/GlyCAM-1 family. extracellular region plasma membrane cell adhesion response to bacterium membrane sulfate binding cell adhesion molecule binding uc007xyk.1 uc007xyk.2 uc007xyk.3 uc007xyk.4 uc007xyk.5 
ENSMUST00000023140.6 Tnfrsf17 ENSMUST00000023140.6 tumor necrosis factor receptor superfamily, member 17 (from RefSeq NM_011608.1) Bcm Bcma ENSMUST00000023140.1 ENSMUST00000023140.2 ENSMUST00000023140.3 ENSMUST00000023140.4 ENSMUST00000023140.5 NM_011608 O88472 TNR17_MOUSE uc007yfh.1 uc007yfh.2 uc007yfh.3 Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK (By similarity). Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Membrane ; Single-pass type III membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88472-1; Sequence=Displayed; Name=2; IsoId=O88472-2; Sequence=VSP_006507; Detected in spleen, thymus, bone marrow and heart, and at lower levels in kidney and lung. adaptive immune response lymphocyte homeostasis immune system process signal transduction membrane integral component of membrane signaling receptor activity uc007yfh.1 uc007yfh.2 uc007yfh.3 
ENSMUST00000023143.14 Litaf ENSMUST00000023143.14 LPS-induced TN factor (from RefSeq NM_019980.2) ENSMUST00000023143.1 ENSMUST00000023143.10 ENSMUST00000023143.11 ENSMUST00000023143.12 ENSMUST00000023143.13 ENSMUST00000023143.2 ENSMUST00000023143.3 ENSMUST00000023143.4 ENSMUST00000023143.5 ENSMUST00000023143.6 ENSMUST00000023143.7 ENSMUST00000023143.8 ENSMUST00000023143.9 LITAF_MOUSE N4wbp3 NM_019980 Q9EQI0 Q9JLJ0 Tbx1 uc007yen.1 uc007yen.2 uc007yen.3 uc007yen.4 Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4 (By similarity). May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005, PubMed:21980379). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:12355436, PubMed:15025820, PubMed:16954198, PubMed:21980379, PubMed:22160695). Monomer. Interacts with NEDD4 (PubMed:11042109). Interacts (via PSAP motif) with TSG101, a component of the ESCRT-I complex (endosomal sorting complex required for transport I). Interacts with WWOX. Interacts with STAM, a component of the ESCRT-0 complex; the interaction is direct. Identified in a complex with STAM and HGS; within this complex, interacts directly with STAM, but not with HGS. Interacts with STAT6 (PubMed:15793005). Q9JLJ0; P46935: Nedd4; NbExp=5; IntAct=EBI-643664, EBI-773516; Cytoplasm Nucleus Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Early endosome membrane Late endosome membrane Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus membrane Note=Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (PubMed:22729949). Detected in brain, heart, lung, liver, spleen and bone marrow (PubMed:22160695). Detected in myelinating Schwann cells in sciatic nerve and in bone marrow-derived macrophages (at protein level) (PubMed:22729949). Widely expressed. Highly expressed in liver. Expression in sciatic nerve is low in neonates, culminates seven days after birth and decreases rapidly thereafter (at protein level) (PubMed:22729949). Strong expression is detected at E.7 and drops at 11 dpc. Up-regulated in macrophages exposed to lipopolysaccharide (LPS) (at protein level) (PubMed:15793005). By estrogen and lipopolysaccharides (LPS). The PPxY motif mediates interaction with WWOX and NEDD4. The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes. It interacts specifically with phosphatidylethanolamine lipid headgroups, but not with phosphoglycerol, phosphocholine, phosphoserine or inositolhexakisphosphate. Phosphorylated on tyrosine residues in response to EGF. No visible phenotype. Mice are born at the expected Mendelian rate and are fertile. Mutant mice display altered responses to nerve crush injury, with higher numbers of macrophages in injured nerves five days after nerve crush injury, but at later time points macrophage numbers in injured nerves are normal. Bone marrow- derived macrophages from mutant mice display increased migration in response to CCL3, but not in the absence of CCL3 (PubMed:22729949). Mutant mice show dramatically increased survival in response to a dose of lipopolysaccharide (LPS) that causes rapid death of 40% of wild-type mice (PubMed:22160695). Belongs to the CDIP1/LITAF family. Sequence=AAG44246.1; Type=Erroneous initiation; Evidence=; Golgi membrane RNA polymerase II core promoter proximal region sequence-specific DNA binding regulation of cytokine production DNA binding protein binding nucleus nucleoplasm cytoplasm lysosome lysosomal membrane endosome Golgi apparatus cytosol plasma membrane aging zinc ion binding cytoplasmic side of plasma membrane endosome membrane membrane early endosome membrane late endosome membrane response to lipopolysaccharide positive regulation of I-kappaB kinase/NF-kappaB signaling intracellular membrane-bounded organelle positive regulation of transcription from RNA polymerase II promoter metal ion binding WW domain binding cellular response to lipopolysaccharide cytoplasmic side of early endosome membrane cytoplasmic side of late endosome membrane cytoplasmic side of lysosomal membrane negative regulation of NIK/NF-kappaB signaling uc007yen.1 uc007yen.2 uc007yen.3 uc007yen.4 
ENSMUST00000023146.5 Nubp1 ENSMUST00000023146.5 nucleotide binding protein 1, transcript variant 2 (from RefSeq NR_190179.1) ENSMUST00000023146.1 ENSMUST00000023146.2 ENSMUST00000023146.3 ENSMUST00000023146.4 NR_190179 NUBP1_MOUSE Q3U053 Q7TMI1 Q9CRM5 Q9R060 uc007ydo.1 uc007ydo.2 uc007ydo.3 uc007ydo.4 uc007ydo.5 Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity). Implicated in the regulation of centrosome duplication (PubMed:16638812, PubMed:23807208). Negatively regulates cilium formation and structure (PubMed:23807208). Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer. Heterotetramer of 2 NUBP1 and 2 NUBP2 chains (PubMed:16638812). Interacts with KIFC1 (PubMed:16638812). Interacts with NUBP2 (PubMed:16638812). Interacts with the BBS/CCT complex subunit CCT1 (PubMed:23807208). Cytoplasm cleus Cell projection Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis. Localized at centrioles and in the nucleus at interphase. Colocalizes with NUBP2 at prometaphase. Specifically localizes to the axenome of motile cilia as opposed to primary non-motile cilia. Localization is independent of NUBP2 and KIFC1. Expressed in trachea epithelial cells, and kidney inner medullary collecting duct cells. High and constant expression in cycling cells. Down- regulated upon cell cycle exit and quiescence. NIH3T3 cells expressing reduced levels of Nubp1 show an increase in number of centrosomes per cell and an increase in the fraction of multinucleated cells. Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. nucleotide binding regulation of cell growth protein binding ATP binding nucleus cytoplasm centriole cytosol cytoskeleton plasma membrane cilium cellular iron ion homeostasis negative regulation of centrosome duplication iron-sulfur cluster assembly cell projection organization cell projection metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding centrosome localization protein localization to cell cortex uc007ydo.1 uc007ydo.2 uc007ydo.3 uc007ydo.4 uc007ydo.5 
ENSMUST00000023147.8 Ciita ENSMUST00000023147.8 class II transactivator, transcript variant 2 (from RefSeq NM_007575.4) C2ta Ciita ENSMUST00000023147.1 ENSMUST00000023147.2 ENSMUST00000023147.3 ENSMUST00000023147.4 ENSMUST00000023147.5 ENSMUST00000023147.6 ENSMUST00000023147.7 NM_007575 Q3U5G4 Q3U5G4_MOUSE uc007ydu.1 uc007ydu.2 uc007ydu.3 uc007ydu.4 uc007ydu.5 This gene encodes a member of the NOD-like receptor protein family. This protein acts as a transcriptional coactivator and component of the enhanceosome complex to stimulate transcription of MHC class II genes in the adaptive immune response. This protein may also regulate the transcription of MHC class I genes. Mutations in the human gene have been linked to a rare immunodeficiency, bare lymphocyte syndrome, and homozygous knockout mice exhibit many features of this disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. negative regulation of transcription from RNA polymerase II promoter nucleotide binding ATP binding regulation of transcription, DNA-templated inflammatory response aging cell surface positive regulation of MHC class II biosynthetic process positive regulation of transcription from RNA polymerase II promoter cellular response to electrical stimulus cellular response to interferon-gamma cellular response to exogenous dsRNA uc007ydu.1 uc007ydu.2 uc007ydu.3 uc007ydu.4 uc007ydu.5 
ENSMUST00000023150.7 Hapstr1 ENSMUST00000023150.7 HUWE1 associated protein modifying stress responses (from RefSeq NM_001081400.3) ENSMUST00000023150.1 ENSMUST00000023150.2 ENSMUST00000023150.3 ENSMUST00000023150.4 ENSMUST00000023150.5 ENSMUST00000023150.6 HAPR1_MOUSE Hapstr1 NM_001081400 Q14AM7 Q9D905 uc007yda.1 uc007yda.2 uc007yda.3 uc007yda.4 Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs. Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage. May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1. Homooligomer. Heterooligomer with HAPSTR2; the interaction is direct and stabilizes HAPSTR1. Interacts with HUWE1. Nucleus Cytoplasm Ubiquitinated by HUWE1. Promotes HAPSTR1 degradation through polyubiquitination. Belongs to the HAPSTR1 family. Sequence=BAB25061.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc007yda.1 uc007yda.2 uc007yda.3 uc007yda.4 
ENSMUST00000023151.6 Bcl6 ENSMUST00000023151.6 B cell leukemia/lymphoma 6, transcript variant 1 (from RefSeq NM_009744.5) Bcl6 ENSMUST00000023151.1 ENSMUST00000023151.2 ENSMUST00000023151.3 ENSMUST00000023151.4 ENSMUST00000023151.5 NM_009744 Q544F9 Q544F9_MOUSE uc007ytz.1 uc007ytz.2 uc007ytz.3 negative regulation of transcription from RNA polymerase II promoter nucleic acid binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm replication fork Golgi apparatus cellular response to DNA damage stimulus negative regulation of cell growth identical protein binding positive regulation of apoptotic process sequence-specific DNA binding positive regulation of regulatory T cell differentiation negative regulation of transcription, DNA-templated uc007ytz.1 uc007ytz.2 uc007ytz.3 
ENSMUST00000023154.3 Cldn1 ENSMUST00000023154.3 claudin 1 (from RefSeq NM_016674.4) Cldn1 ENSMUST00000023154.1 ENSMUST00000023154.2 NM_016674 Q4FJV3 Q4FJV3_MOUSE uc007yuz.1 uc007yuz.2 uc007yuz.3 uc007yuz.4 uc007yuz.5 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene die soon after birth as a consequence of dehydration from trandermal water loss, indicating that this gene is indispensable for creating and maintaining the epidermal barrier. The protein encoded by this gene also has gastric tumor suppressive activity, and is a key factor for hepatitis C virus (HCV) entry. [provided by RefSeq, Aug 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008536.1, AK036780.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the claudin family. Lacks conserved residue(s) required for the propagation of feature annotation. virus receptor activity structural molecule activity cytoplasm plasma membrane integral component of plasma membrane bicellular tight junction aging establishment of blood-nerve barrier response to toxic substance membrane integral component of membrane basolateral plasma membrane apical plasma membrane lateral plasma membrane cell junction positive regulation of cell migration response to lipopolysaccharide macromolecular complex hyperosmotic salinity response cell-cell junction organization response to ethanol viral entry into host cell protein oligomerization protein homooligomerization protein heterooligomerization positive regulation of epithelial cell proliferation involved in wound healing establishment of skin barrier drug transport across blood-nerve barrier response to interleukin-18 bicellular tight junction assembly cellular response to lead ion cellular response to interferon-gamma cellular response to tumor necrosis factor response to dexamethasone cellular response to transforming growth factor beta stimulus positive regulation of wound healing establishment of endothelial intestinal barrier liver regeneration positive regulation of bicellular tight junction assembly cellular response to butyrate uc007yuz.1 uc007yuz.2 uc007yuz.3 uc007yuz.4 uc007yuz.5 
ENSMUST00000023156.13 Il1rap ENSMUST00000023156.13 interleukin 1 receptor accessory protein, transcript variant 1 (from RefSeq NM_008364.2) ENSMUST00000023156.1 ENSMUST00000023156.10 ENSMUST00000023156.11 ENSMUST00000023156.12 ENSMUST00000023156.2 ENSMUST00000023156.3 ENSMUST00000023156.4 ENSMUST00000023156.5 ENSMUST00000023156.6 ENSMUST00000023156.7 ENSMUST00000023156.8 ENSMUST00000023156.9 IL1AP_MOUSE NM_008364 Q3UVZ1 Q61730 Q8VCB9 uc007yve.1 uc007yve.2 uc007yve.3 uc007yve.4 Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed:25908590). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity). [Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling. [Isoform 3]: Required for Src phosphorylation by IL1B. Required for IL1B-potentiated NMDA-induced calcium influx in neurons acting in cooperation with IL1R1 isoform 2 to mediate Akt kinase activation. Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302; Evidence=; The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN. The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex. Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88. Interacts (via the first immunoglobilin domain) with PTPRD (via the third immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (PubMed:25908590). Q61730; P14719: Il1rl1; NbExp=3; IntAct=EBI-525035, EBI-525078; Q61730; Q9QZ06: Tollip; NbExp=2; IntAct=EBI-525035, EBI-74272; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. [Isoform 2]: Secreted. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=MuIL-1R AcP; IsoId=Q61730-1; Sequence=Displayed; Name=2; Synonyms=SmuIL-1R AcP; IsoId=Q61730-2; Sequence=VSP_008054, VSP_008055; Name=3; Synonyms=IL-1RAcPb; IsoId=Q61730-3; Sequence=VSP_058171; Detected in lung, brain, spleen, thymus and liver. Expressed in brain endothelial cells, astrocytes, microglia and neurons. Isoform 3 is predominantly expressed in brain; expressed in hippocampal neurons. The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. Belongs to the interleukin-1 receptor family. interleukin-33 receptor activity immune system process interleukin-1 receptor activity interleukin-1 receptor binding protein binding extracellular region extracellular space cytoplasm plasma membrane inflammatory response signal transduction membrane integral component of membrane cytokine-mediated signaling pathway positive regulation of interleukin-13 production positive regulation of interleukin-5 production macromolecular complex interleukin-33-mediated signaling pathway interleukin-2 biosynthetic process innate immune response positive regulation of NF-kappaB transcription factor activity positive regulation of synapse assembly interleukin-4 secretion glutamatergic synapse trans-synaptic signaling by trans-synaptic complex synaptic membrane adhesion positive regulation of dendrite development regulation of presynapse assembly protein tyrosine kinase binding positive regulation of interleukin-6 secretion uc007yve.1 uc007yve.2 uc007yve.3 uc007yve.4 
ENSMUST00000023157.6 Anks3 ENSMUST00000023157.6 ankyrin repeat and sterile alpha motif domain containing 3 (from RefSeq NM_028301.5) ANKS3_MOUSE ENSMUST00000023157.1 ENSMUST00000023157.2 ENSMUST00000023157.3 ENSMUST00000023157.4 ENSMUST00000023157.5 Kiaa1977 NM_028301 Q6ZPF6 Q80X46 Q9CZK6 uc007ybc.1 uc007ybc.2 uc007ybc.3 uc007ybc.4 May be involved in vasopressin signaling in the kidney. Homooligomer (By similarity). Interacts (via SAM domain) with ANKS6 (via SAM domain) (PubMed:25671767, PubMed:26327442, PubMed:26188091). Interacts with BICC1 (PubMed:25671767). Interacts with NPHP1 (PubMed:25671767). Interacts with NEK8 (PubMed:25671767, PubMed:26188091). Interacts with HIF1AN (PubMed:25671767). Interacts with NEK7; this interaction alters the subcellular distribution of NEK7 by preventing its nuclear translocation (PubMed:26188091). Cell projection, cilium Cytoplasm Kidney (at protein level). The SAM domain mediates homooligomerization. Hydroxylated at Asn-96, most probably by HIF1AN. Phosphorylations at Ser-5, Ser-225, Thr-318, Ser-319, Ser-366 and Ser-369 occur in a NEK7-dependent manner. Polyubiquitinated. protein binding cellular_component cytoplasm cilium biological_process uc007ybc.1 uc007ybc.2 uc007ybc.3 uc007ybc.4 
ENSMUST00000023165.9 Crebbp ENSMUST00000023165.9 CREB binding protein (from RefSeq NM_001025432.1) Crebbp ENSMUST00000023165.1 ENSMUST00000023165.2 ENSMUST00000023165.3 ENSMUST00000023165.4 ENSMUST00000023165.5 ENSMUST00000023165.6 ENSMUST00000023165.7 ENSMUST00000023165.8 F8VPR5 F8VPR5_MOUSE NM_001025432 uc007xzl.1 uc007xzl.2 uc007xzl.3 Cytoplasm negative regulation of transcription from RNA polymerase II promoter histone acetyltransferase complex nuclear chromatin core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor binding p53 binding chromatin binding damaged DNA binding transcription cofactor activity transcription coactivator activity transcription corepressor activity histone acetyltransferase activity nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated protein acetylation transcription factor binding zinc ion binding acetyltransferase activity histone acetylation nuclear body transferase activity transferase activity, transferring acyl groups N-terminal peptidyl-lysine acetylation positive regulation of transforming growth factor beta receptor signaling pathway protein destabilization cellular response to UV MRF binding positive regulation of transcription, DNA-templated metal ion binding uc007xzl.1 uc007xzl.2 uc007xzl.3 
ENSMUST00000023171.8 Hes1 ENSMUST00000023171.8 hes family bHLH transcription factor 1, transcript variant 1 (from RefSeq NM_008235.3) ENSMUST00000023171.1 ENSMUST00000023171.2 ENSMUST00000023171.3 ENSMUST00000023171.4 ENSMUST00000023171.5 ENSMUST00000023171.6 ENSMUST00000023171.7 Hes1 NM_008235 Q3UZZ2 Q3UZZ2_MOUSE uc007ywl.1 uc007ywl.2 uc007ywl.3 Nucleus negative regulation of transcription from RNA polymerase II promoter DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated Notch signaling pathway histone deacetylase binding negative regulation of transcription, DNA-templated protein dimerization activity neuronal stem cell population maintenance negative regulation of stem cell differentiation negative regulation of pro-B cell differentiation uc007ywl.1 uc007ywl.2 uc007ywl.3 
ENSMUST00000023176.5 Zfp263 ENSMUST00000023176.5 zinc finger protein 263 (from RefSeq NM_148924.3) E9PXW0 ENSMUST00000023176.1 ENSMUST00000023176.2 ENSMUST00000023176.3 ENSMUST00000023176.4 FPM315 NM_148924 Q7TMI6 Q8CF60 Q8K439 ZKSCAN12 ZN263_MOUSE Zfp263 Znf263 uc007xyn.1 uc007xyn.2 uc007xyn.3 uc007xyn.4 Transcription factor that binds to the consensus sequence 5'- TCCTCCC-3' and acts as a transcriptional repressor (By similarity). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (By similarity). Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (By similarity). Interacts with a number of proteins involved in chromatin modification and transcriptional corepression including DNMT1, DNMT3A, HDAC2, PHF8, TRIM28/KAP1, SETDB1, EZH2, UHRF1, CBX3/HP1-gamma, and CBX5/HP1-alpha; recruits these proteins to the SIX3 promoter region, leading to SIX3 transcriptional repression (By similarity). Interacts with MAPK3/ERK1 and MAPK1/ERK2 (By similarity). Nucleus Expressed in Purkinje cells in the brain (at protein level). Ubiquitinated, leading to proteasomal degradation. Belongs to the krueppel C2H2-type zinc-finger protein family. An isoform of Znf263 lacking residues 1-288 was described, however this paper was retracted due to concerns about the validity of figures published in the paper. negative regulation of transcription from RNA polymerase II promoter nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding negative regulation of transcription, DNA-templated metal ion binding uc007xyn.1 uc007xyn.2 uc007xyn.3 uc007xyn.4 
ENSMUST00000023179.7 Zfp7 ENSMUST00000023179.7 zinc finger protein 7, transcript variant 2 (from RefSeq NM_145916.5) ENSMUST00000023179.1 ENSMUST00000023179.2 ENSMUST00000023179.3 ENSMUST00000023179.4 ENSMUST00000023179.5 ENSMUST00000023179.6 NM_145916 Q3TFZ4 Q3TFZ4_MOUSE Zfp7 uc007wmo.1 uc007wmo.2 uc007wmo.3 uc007wmo.4 uc007wmo.5 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007wmo.1 uc007wmo.2 uc007wmo.3 uc007wmo.4 uc007wmo.5 
ENSMUST00000023180.15 Mefv ENSMUST00000023180.15 Mediterranean fever, transcript variant 3 (from RefSeq NM_019453.2) E9QN30 ENSMUST00000023180.1 ENSMUST00000023180.10 ENSMUST00000023180.11 ENSMUST00000023180.12 ENSMUST00000023180.13 ENSMUST00000023180.14 ENSMUST00000023180.2 ENSMUST00000023180.3 ENSMUST00000023180.4 ENSMUST00000023180.5 ENSMUST00000023180.6 ENSMUST00000023180.7 ENSMUST00000023180.8 ENSMUST00000023180.9 MEFV_MOUSE Mefv NM_019453 Q9JJ26 uc007xym.1 uc007xym.2 uc007xym.3 uc007xym.4 Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:34471287). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (By similarity). Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (By similarity). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (By similarity). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (PubMed:34471287). It is required for PSTPIP1- induced PYCARD/ASC oligomerization and inflammasome formation (By similarity). Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (By similarity). Homotrimer. Interacts (via the B box-type zinc finger) with PSTPIP1 (By similarity). Interacts (via the B30.2/SPRY domain) with several components of the inflammasome complex, including CASP1 p20 and p10 subunits, CASP5, PYCARD, NLRP1, NLRP2 and NLRP3, as well as with unprocessed IL1B; this interaction may lead to autophagic degradation of these proteins (By similarity). Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis) (PubMed:34471287). Interacts with NFKBIA and RELA (By similarity). Interacts weakly with VASP and ACTR3 (By similarity). Interacts with active ULK1 (phosphorylated on 'Ser-317') and BECN1 simultaneously (By similarity). Also interacts with ATG16L1 (via WD repeats), and with ATG8 family members, including GABARAP, GABARAPL1 and, to a lesser extent, GABARAPL2, MAP1LC3A/LC3A and MAP1LC3C/LC3C (By similarity). Interacts with TRIM21 (By similarity). Interacts with YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; the interaction is required for the down-regulation of pyrin pro-inflammatory activity (By similarity). Cytoplasm, cytoskeleton Cell projection, ruffle Cell projection, lamellipodium Cytoplasm Cytoplasmic vesicle, autophagosome Nucleus Note=Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles. In pre-apoptotic cells, colocalizes with PYCARD/ASC in large specks (pyroptosomes). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC (By similarity). Expressed in spleen peripheral blood granulocytes. Not expressed in lymphocytes, thymus, testis, ovary, heart, brain, lung, liver, kidney and muscle. The B box-type zinc finger interacts, possibly intramolecularly, with the pyrin domain; this may be an autoinhibitory mechanism released by PSTPIP1 binding. Phosphorylation at Ser-241 is required for the interaction with 14-3-3 proteins and down-regulation of pyrin pro-inflammatory activity. Degraded along with the delivery of its substrates to autolysosomal compartments (at protein level). Animals are grossly normal, with no obvious changes in thymus, spleen or lymph nodes. In vitro, resident peritoneal macrophage cells show enhanced IL1B and IL18 release in response to inflammatory stimuli. Lacks the B30.2/SPRY domain found in the human ortholog, thus may have divergent function(s). ruffle immune system process actin binding nucleus cytoplasm autophagosome cytoskeleton microtubule microtubule associated complex inflammatory response zinc ion binding positive regulation of autophagy lamellipodium cytoplasmic vesicle negative regulation of interleukin-1 beta production negative regulation of interleukin-12 production response to interferon-gamma identical protein binding cell projection innate immune response metal ion binding negative regulation of inflammatory response negative regulation of macrophage inflammatory protein 1 alpha production negative regulation of cytokine production involved in inflammatory response negative regulation of NLRP3 inflammasome complex assembly positive regulation of cysteine-type endopeptidase activity uc007xym.1 uc007xym.2 uc007xym.3 uc007xym.4 
ENSMUST00000023206.14 Ercc4 ENSMUST00000023206.14 excision repair cross-complementing rodent repair deficiency, complementation group 4, transcript variant 2 (from RefSeq NR_190181.1) ENSMUST00000023206.1 ENSMUST00000023206.10 ENSMUST00000023206.11 ENSMUST00000023206.12 ENSMUST00000023206.13 ENSMUST00000023206.2 ENSMUST00000023206.3 ENSMUST00000023206.4 ENSMUST00000023206.5 ENSMUST00000023206.6 ENSMUST00000023206.7 ENSMUST00000023206.8 ENSMUST00000023206.9 Ercc4 NR_190181 O54810 Q8R0I3 Q9QZD4 XPF_MOUSE Xpf uc007yfx.1 uc007yfx.2 uc007yfx.3 uc007yfx.4 Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Heterodimer composed of ERCC1 and ERCC4/XPF. Interacts with SLX4/BTBD12; this interaction is direct and links the ERCC1-ERCC4/XPF complex to SLX4, which may coordinate the action of the structure- specific endonuclease during DNA repair. Nucleus Chromosome Note=Localizes to sites of DNA damage. Acetylation at Lys-912 by KAT5 promotes interaction with ERCC1 by disrupting a salt bridge between Asp-908 and Lys-912, thereby exposing a second binding site for ERCC1 (By similarity). Deacetylated by SIRT1 (By similarity). Belongs to the XPF family. Sequence=AAH26792.1; Type=Erroneous initiation; Evidence=; single-stranded DNA endodeoxyribonuclease activity nucleotide-excision repair complex nucleotide-excision repair factor 1 complex resolution of meiotic recombination intermediates telomere maintenance double-strand break repair via homologous recombination chromosome, telomeric region nuclear chromosome, telomeric region TFIID-class transcription factor binding DNA binding damaged DNA binding single-stranded DNA binding nuclease activity endonuclease activity endodeoxyribonuclease activity protein binding nucleus transcription factor TFIID complex DNA repair nucleotide-excision repair nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion double-strand break repair via nonhomologous end joining cellular response to DNA damage stimulus protein C-terminus binding response to UV UV protection regulation of autophagy hydrolase activity negative regulation of telomere maintenance nucleotide-excision repair, DNA incision cellular response to UV identical protein binding protein N-terminus binding telomeric DNA-containing double minutes formation ERCC4-ERCC1 complex nucleotide-excision repair involved in interstrand cross-link repair negative regulation of telomere maintenance via telomere lengthening negative regulation of protection from non-homologous end joining at telomere negative regulation of double-stranded telomeric DNA binding 3' overhang single-stranded DNA endodeoxyribonuclease activity uc007yfx.1 uc007yfx.2 uc007yfx.3 uc007yfx.4 
ENSMUST00000023210.8 Cyc1 ENSMUST00000023210.8 cytochrome c-1 (from RefSeq NM_025567.3) CY1_MOUSE ENSMUST00000023210.1 ENSMUST00000023210.2 ENSMUST00000023210.3 ENSMUST00000023210.4 ENSMUST00000023210.5 ENSMUST00000023210.6 ENSMUST00000023210.7 NM_025567 Q3TDC5 Q3UAN2 Q63ZW4 Q9D0M3 Q9DCG0 uc007wjs.1 uc007wjs.2 uc007wjs.3 Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c. Reaction=a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out); Xref=Rhea:RHEA:11484, Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:132124; EC=7.1.1.8; Evidence=; Name=heme c; Xref=ChEBI:CHEBI:61717; Evidence=; Note=Binds 1 heme c group covalently per subunit. ; Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:19026783). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding. Mitochondrion inner membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D0M3-1; Sequence=Displayed; Name=2; IsoId=Q9D0M3-2; Sequence=VSP_025056; Belongs to the cytochrome c family. Sequence=AAH82790.1; Type=Erroneous initiation; Evidence=; protein binding mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex III mitochondrial electron transport, ubiquinol to cytochrome c electron carrier activity membrane integral component of membrane heme binding response to glucagon mitochondrial ATP synthesis coupled proton transport electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity metal ion binding oxidation-reduction process respiratory chain uc007wjs.1 uc007wjs.2 uc007wjs.3 
ENSMUST00000023211.16 Sharpin ENSMUST00000023211.16 SHANK-associated RH domain interacting protein (from RefSeq NM_025340.2) Cpdm ENSMUST00000023211.1 ENSMUST00000023211.10 ENSMUST00000023211.11 ENSMUST00000023211.12 ENSMUST00000023211.13 ENSMUST00000023211.14 ENSMUST00000023211.15 ENSMUST00000023211.2 ENSMUST00000023211.3 ENSMUST00000023211.4 ENSMUST00000023211.5 ENSMUST00000023211.6 ENSMUST00000023211.7 ENSMUST00000023211.8 ENSMUST00000023211.9 NM_025340 Q7TNT3 Q8CHL3 Q91WA6 SHRPN_MOUSE Sipl1 uc007wju.1 uc007wju.2 uc007wju.3 uc007wju.4 Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17538631, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17538631, PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17538631, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin. The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity). Protein modification; protein ubiquitination. Monomer and homodimer (By similarity). Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31 (By similarity). LUBAC has a MW of approximately 600 kDa suggesting a heteromultimeric assembly of its subunits (By similarity). Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner (By similarity). Interacts with EYA1, EYA2, SHANK1 and SHANK3 (via ANK repeats) (PubMed:20956555). Q91WA6; P97767: Eya1; NbExp=4; IntAct=EBI-646097, EBI-1368503; Q91WA6; O08575: Eya2; NbExp=2; IntAct=EBI-646097, EBI-986503; Q91WA6; Q924T7: Rnf31; NbExp=10; IntAct=EBI-646097, EBI-647680; Cytoplasm, cytosol Synapse Note=Enriched at synaptic sites in mature neurons where it colocalizes with SHANK1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91WA6-1; Sequence=Displayed; Name=2; IsoId=Q91WA6-2; Sequence=VSP_023839; Highly expressed in thymus and spleen. Present at high level in splenic B- and T-cells (at protein level). The Ubiquitin-like domain is required for the interaction with RNF31. The RanBP2-type zinc fingers mediate the specific interaction with ubiquitin. Binds preferentially linear polyubiquitin chains and 'Lys-63'-linked polyubiquitin chains over 'Lys-48'-linked polyubiquitin chains. Also binds monoubiquitin (By similarity). Note=Defects in Sharpin are the cause of chronic proliferative dermatitis (cpdm). Cpdm is a spontaneous mutation causing a chronic proliferative dermatitis phenotype, which is characterized histologically by severe inflammation, eosinophilic dermatitis and defects in secondary lymphoid organ development. Mice also display lower total and cortical bone mineral content and bone mineral density, trabecular and cortical bone volume, and trabecular number. TNF-alpha- induced NF-kappa-B activation is attenuated due to inability of the LUBAC complex to mediate linear ubiquitination. protein binding cytoplasm cytosol mitochondrion organization brain development epidermis development regulation of tumor necrosis factor-mediated signaling pathway postsynaptic density cell junction apoptotic nuclear changes dendrite keratinization polyubiquitin binding identical protein binding positive regulation of I-kappaB kinase/NF-kappaB signaling macromolecular complex binding synapse metal ion binding negative regulation of inflammatory response protein homooligomerization LUBAC complex protein linear polyubiquitination regulation of CD40 signaling pathway uc007wju.1 uc007wju.2 uc007wju.3 uc007wju.4 
ENSMUST00000023213.8 Hgh1 ENSMUST00000023213.8 HGH1 homolog, transcript variant 3 (from RefSeq NR_177984.1) Brp16 ENSMUST00000023213.1 ENSMUST00000023213.2 ENSMUST00000023213.3 ENSMUST00000023213.4 ENSMUST00000023213.5 ENSMUST00000023213.6 ENSMUST00000023213.7 Fam203a HGH1_MOUSE MNCb-5873 NR_177984 Q8C3I8 Q9JJF4 uc007wjz.1 uc007wjz.2 uc007wjz.3 uc007wjz.4 Belongs to the HGH1 family. molecular_function cellular_component uc007wjz.1 uc007wjz.2 uc007wjz.3 uc007wjz.4 
ENSMUST00000023214.11 Dgat1 ENSMUST00000023214.11 diacylglycerol O-acyltransferase 1, transcript variant 2 (from RefSeq NR_177195.1) DGAT1_MOUSE Dgat Dgat1 ENSMUST00000023214.1 ENSMUST00000023214.10 ENSMUST00000023214.2 ENSMUST00000023214.3 ENSMUST00000023214.4 ENSMUST00000023214.5 ENSMUST00000023214.6 ENSMUST00000023214.7 ENSMUST00000023214.8 ENSMUST00000023214.9 NR_177195 Q9D7Q5 Q9Z2A7 uc007wkn.1 uc007wkn.2 uc007wkn.3 Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:15834126, PubMed:19028692, PubMed:20876538, PubMed:22493088, PubMed:28420705). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (By similarity). In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed:15834126). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (By similarity). In contrast to DGAT2 it is not essential for survival (PubMed:11959864). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:19028692). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (PubMed:15834126). Also able to use 1- monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). Reaction=a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA; Xref=Rhea:RHEA:10868, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64615; EC=2.3.1.20; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10869; Evidence=; Reaction=all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA; Xref=Rhea:RHEA:11488, ChEBI:CHEBI:17336, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:63410; EC=2.3.1.76; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11489; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA; Xref=Rhea:RHEA:38307, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75728, ChEBI:CHEBI:75729; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38308; Evidence=; Reaction=hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O- dihexadecanoyl-1,2-hexadecanediol + 2 CoA; Xref=Rhea:RHEA:38211, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75586, ChEBI:CHEBI:75608; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38212; Evidence=; Reaction=hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA; Xref=Rhea:RHEA:38171, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75586, ChEBI:CHEBI:75587; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38172; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1- hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA; Xref=Rhea:RHEA:38071, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:73990, ChEBI:CHEBI:75466; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38072; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2- di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA; Xref=Rhea:RHEA:38163, ChEBI:CHEBI:52333, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75583; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38164; Evidence=; Reaction=hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoate; Xref=Rhea:RHEA:38167, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75584; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38168; Evidence=; Reaction=all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA; Xref=Rhea:RHEA:38175, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38176; Evidence=; Reaction=13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA; Xref=Rhea:RHEA:55296, ChEBI:CHEBI:45479, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:138722; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55297; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219, ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38220; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38435, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75735; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38436; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38439, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75824; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38440; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O- (9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:55340, ChEBI:CHEBI:34116, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:197429; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55341; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:37915, ChEBI:CHEBI:52323, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37916; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di- (9Z-octadecenoyl)-sn-glycerol + CoA; Xref=Rhea:RHEA:37911, ChEBI:CHEBI:52333, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:73990; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37912; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecyl)-3-(9Z- octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z- octadecenoyl)glycerol + CoA; Xref=Rhea:RHEA:55344, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:138735, ChEBI:CHEBI:197429; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55345; Evidence=; Reaction=(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O; Xref=Rhea:RHEA:38379, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52323, ChEBI:CHEBI:53753; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38380; Evidence=; Lipid metabolism; glycerolipid metabolism. Homodimer or homotetramer; both forms have similar enzymatic activities. Endoplasmic reticulum membrane ; Multi-pass membrane protein The disordered N-terminal region is required for the diacylglycerol O-acyltransferase activity and may regulate enzymatic function via its interaction with the MBOAT fold. The MBOAT fold forms a reaction chamber in the endoplasmic reticulum membrane that encloses the active sites. The reaction chamber has a tunnel to the cytosolic side and its entrance recognizes the hydrophilic CoA motif of an acyl-CoA molecule. The chamber has separate entrances for each of the two substrates, acyl-CoA and 1,2-diacyl-sn- glycerol. Mice are viable and live well, but show substantially reduced levels of triacylglycerides in all tissues (PubMed:10802663, PubMed:11959864, PubMed:11956242). Mice are resistant to obesity when kept on a high-fat diet due to increased energy expenditure: they display reduced postabsorptive chylomicronemia and accumulate neutral-lipid droplets in the cytoplasm of enterocytes (PubMed:10802663, PubMed:11959864, PubMed:11956242). Mice also show increased sensitivity to insulin and to leptin and are protected against insulin resistance (PubMed:11956242). Mutant mice show reduced levels of monoalkyl-monoacylglycerol (MADAG) in the adrenal gland (PubMed:28420705). Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. 2-acylglycerol O-acyltransferase activity diacylglycerol O-acyltransferase activity fatty acid binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane O-acyltransferase activity positive regulation of triglyceride biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups triglyceride biosynthetic process lipid storage diacylglycerol binding insulin secretion very-low-density lipoprotein particle assembly long-chain fatty-acyl-CoA metabolic process retinol metabolic process intracellular membrane-bounded organelle positive regulation of fatty acid oxidation diacylglycerol metabolic process glycerolipid metabolic process retinol O-fatty-acyltransferase activity fatty acid homeostasis regulation of vitamin A metabolic process ketone body metabolic process regulation of eating behavior regulation of intestinal lipid absorption positive regulation of hepatic stellate cell activation uc007wkn.1 uc007wkn.2 uc007wkn.3 
ENSMUST00000023217.11 Bop1 ENSMUST00000023217.11 block of proliferation 1 (from RefSeq NM_013481.2) BOP1_MOUSE ENSMUST00000023217.1 ENSMUST00000023217.10 ENSMUST00000023217.2 ENSMUST00000023217.3 ENSMUST00000023217.4 ENSMUST00000023217.5 ENSMUST00000023217.6 ENSMUST00000023217.7 ENSMUST00000023217.8 ENSMUST00000023217.9 Kiaa0124 NM_013481 P97452 Q3TK87 Q6ZQI9 Q91X31 uc007wkf.1 uc007wkf.2 uc007wkf.3 Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:15225545, PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta- propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27 (By similarity). Nucleus, nucleolus. Nucleus, nucleoplasm. Expressed in brain, gut, heart, kidney, liver, lung, muscle, ovary, skin, spleen and testis. Expression in quiescent fibroblasts is induced by serum stimulation. Belongs to the WD repeat BOP1/ERB1 family. Sequence=BAC97868.1; Type=Erroneous initiation; Evidence=; ribosomal large subunit assembly cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) protein binding nucleus nucleoplasm nucleolus rRNA processing cell proliferation preribosome, large subunit precursor ribosome biogenesis ribosomal large subunit biogenesis ribonucleoprotein complex binding regulation of cell cycle PeBoW complex regulation of signal transduction by p53 class mediator ribonucleoprotein complex uc007wkf.1 uc007wkf.2 uc007wkf.3 
ENSMUST00000023219.9 Fbxl6 ENSMUST00000023219.9 F-box and leucine-rich repeat protein 6 (from RefSeq NM_013909.2) ENSMUST00000023219.1 ENSMUST00000023219.2 ENSMUST00000023219.3 ENSMUST00000023219.4 ENSMUST00000023219.5 ENSMUST00000023219.6 ENSMUST00000023219.7 ENSMUST00000023219.8 FBXL6_MOUSE Fbl6 MNCb-1275 NM_013909 Q9JJD7 Q9QXW0 uc007wkq.1 uc007wkq.2 uc007wkq.3 uc007wkq.4 uc007wkq.5 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Directly interacts with SKP1 and CUL1. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9QXW0-1; Sequence=Displayed; Name=2; IsoId=Q9QXW0-2; Sequence=VSP_008500; Name=3; IsoId=Q9QXW0-3; Sequence=VSP_008499; Sequence=AAF22828.1; Type=Frameshift; Evidence=; protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin protein ligase activity uc007wkq.1 uc007wkq.2 uc007wkq.3 uc007wkq.4 uc007wkq.5 
ENSMUST00000023220.10 Slc52a2 ENSMUST00000023220.10 solute carrier protein 52, member 2 (from RefSeq NM_029643.4) ENSMUST00000023220.1 ENSMUST00000023220.2 ENSMUST00000023220.3 ENSMUST00000023220.4 ENSMUST00000023220.5 ENSMUST00000023220.6 ENSMUST00000023220.7 ENSMUST00000023220.8 ENSMUST00000023220.9 Gpr172b NM_029643 Q8CCV8 Q9D8F3 Rft1 S52A2_MOUSE uc007wku.1 uc007wku.2 uc007wku.3 Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. May also act as a receptor for 4- hydroxybutyrate. Reaction=riboflavin(in) = riboflavin(out); Xref=Rhea:RHEA:35015, ChEBI:CHEBI:57986; Evidence=; Riboflavin transport is Na(+)-independent but moderately pH-sensitive (By similarity). Activity is strongly inhibited by riboflavin analogs, such as lumiflavin (By similarity). Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) (By similarity). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D8F3-1; Sequence=Displayed; Name=2; IsoId=Q9D8F3-2; Sequence=VSP_015940, VSP_015941; Belongs to the riboflavin transporter family. plasma membrane integral component of plasma membrane membrane integral component of membrane riboflavin transporter activity riboflavin transport uc007wku.1 uc007wku.2 uc007wku.3 
ENSMUST00000023221.13 Gpaa1 ENSMUST00000023221.13 GPI anchor attachment protein 1 (from RefSeq NM_010331.2) ENSMUST00000023221.1 ENSMUST00000023221.10 ENSMUST00000023221.11 ENSMUST00000023221.12 ENSMUST00000023221.2 ENSMUST00000023221.3 ENSMUST00000023221.4 ENSMUST00000023221.5 ENSMUST00000023221.6 ENSMUST00000023221.7 ENSMUST00000023221.8 ENSMUST00000023221.9 GPAA1_MOUSE Gaa1 NM_010331 Q3TNU9 Q9R1U8 Q9WTK3 uc007wjr.1 uc007wjr.2 uc007wjr.3 Component of the GPI transamidase complex, necessary for transfer of GPI to proteins (By similarity). Essential for GPI- anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Forms a complex with PIGK/GPI8, PIGT, PIGU and PIGS. Endoplasmic reticulum membrane ; Multi-pass membrane protein Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. In embryos abundant in the choroid plexus, skeletal muscle,. GPI-anchor transamidase activity endoplasmic reticulum endoplasmic reticulum membrane integral component of plasma membrane GPI anchor biosynthetic process membrane integral component of membrane attachment of GPI anchor to protein GPI anchor binding GPI-anchor transamidase complex macromolecular complex assembly uc007wjr.1 uc007wjr.2 uc007wjr.3 
ENSMUST00000023222.13 Oplah ENSMUST00000023222.13 5-oxoprolinase (ATP-hydrolysing) (from RefSeq NM_153122.3) ENSMUST00000023222.1 ENSMUST00000023222.10 ENSMUST00000023222.11 ENSMUST00000023222.12 ENSMUST00000023222.2 ENSMUST00000023222.3 ENSMUST00000023222.4 ENSMUST00000023222.5 ENSMUST00000023222.6 ENSMUST00000023222.7 ENSMUST00000023222.8 ENSMUST00000023222.9 NM_153122 OPLA_MOUSE Q8K010 Q8R3K2 uc007wjo.1 uc007wjo.2 Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Reaction=5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate; Xref=Rhea:RHEA:10348, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58402, ChEBI:CHEBI:456216; EC=3.5.2.9; Evidence=; Homodimer. Cytoplasm, cytosol Belongs to the oxoprolinase family. nucleotide binding catalytic activity ATP binding cytosol glutathione metabolic process hydrolase activity 5-oxoprolinase (ATP-hydrolyzing) activity uc007wjo.1 uc007wjo.2 
ENSMUST00000023225.8 Grina ENSMUST00000023225.8 glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) (from RefSeq NM_023168.3) ENSMUST00000023225.1 ENSMUST00000023225.2 ENSMUST00000023225.3 ENSMUST00000023225.4 ENSMUST00000023225.5 ENSMUST00000023225.6 ENSMUST00000023225.7 LFG1_MOUSE Lag Lfg1 NM_023168 Nmdara1 Q8CI25 Q9ESF4 uc007wjl.1 uc007wjl.2 uc007wjl.3 Potential apoptotic regulator. Membrane ; Multi-pass membrane protein Belongs to the BI1 family. LFG subfamily. endoplasmic reticulum Golgi apparatus membrane integral component of membrane endoplasmic reticulum calcium ion homeostasis ion channel binding negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway uc007wjl.1 uc007wjl.2 uc007wjl.3 
ENSMUST00000023237.8 Naprt ENSMUST00000023237.8 nicotinate phosphoribosyltransferase (from RefSeq NM_172607.3) ENSMUST00000023237.1 ENSMUST00000023237.2 ENSMUST00000023237.3 ENSMUST00000023237.4 ENSMUST00000023237.5 ENSMUST00000023237.6 ENSMUST00000023237.7 NM_172607 Naprt1 PNCB_MOUSE Q8C7W2 Q8CC86 uc007whi.1 uc007whi.2 uc007whi.3 Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis. Reaction=5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate; Xref=Rhea:RHEA:36163, ChEBI:CHEBI:15377, ChEBI:CHEBI:30616, ChEBI:CHEBI:32544, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474, ChEBI:CHEBI:57502, ChEBI:CHEBI:58017, ChEBI:CHEBI:456216; EC=6.3.4.21; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Activity is highest with Mn(2+). ; Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D- ribonucleotide from nicotinate: step 1/1. Homodimer. Cytoplasm, cytosol Abundantly expressed in the small intestine, liver and kidney. Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. Belongs to the NAPRTase family. Sequence=BAC33575.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC33575.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; catalytic activity nicotinate-nucleotide diphosphorylase (carboxylating) activity nicotinate phosphoribosyltransferase activity cytoplasm cytosol response to oxidative stress NAD biosynthetic process transferase activity ligase activity pyridine nucleotide biosynthetic process NAD salvage metal ion binding uc007whi.1 uc007whi.2 uc007whi.3 
ENSMUST00000023238.6 Gsdmd ENSMUST00000023238.6 gasdermin D (from RefSeq NM_026960.4) ENSMUST00000023238.1 ENSMUST00000023238.2 ENSMUST00000023238.3 ENSMUST00000023238.4 ENSMUST00000023238.5 GSDMD_MOUSE Gsdmd Gsdmdc1 NM_026960 Q3TBD9 Q9D8T2 uc007whh.1 uc007whh.2 uc007whh.3 [Gasdermin-D]: Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:26611636, PubMed:27383986, PubMed:27385778, PubMed:27418190). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:26611636, PubMed:27383986, PubMed:27385778, PubMed:27418190). [Gasdermin-D, N-terminal]: Promotes pyroptosis in response to microbial infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:26611636, PubMed:27383986, PubMed:27385778, PubMed:27418190, PubMed:32820063, PubMed:34289345, PubMed:35705808). Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4/CASP11 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:26611636, PubMed:27383986, PubMed:27385778, PubMed:27418190, PubMed:35705808). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27383986, PubMed:27339137). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukin-1 (IL1B and IL18) and triggering pyroptosis (PubMed:27383986, PubMed:29274245, PubMed:29195811, PubMed:33883744). Gasdermin pores also allow the release of mature caspase-7 (CASP7) (PubMed:35705808). Also forms pores in the mitochondrial membrane, resulting in release of mitochondrial DNA (mtDNA) into the cytosol (PubMed:37001519). Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27383986). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (PubMed:27383986). Also active in response to MAP3K7/TAK1 inactivation by Yersinia toxin YopJ, which triggers cleavage by CASP8 and subsequent activation (PubMed:30361383, PubMed:30381458). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin. Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27383986). [Gasdermin-D, p13]: Transcription coactivator produced by the cleavage by CASP3 or CASP7 in the upper small intestine in response to dietary antigens (PubMed:37327784). Required to maintain food tolerance in small intestine: translocates to the nucleus and acts as a coactivator for STAT1 to induce the transcription of CIITA and MHC class II molecules, which in turn induce type 1 regulatory T (Tr1) cells in upper small intestine (PubMed:37327784). [Gasdermin-D, p40]: Produced by the cleavage by papain allergen (PubMed:35794369). After cleavage, moves to the plasma membrane and homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the specific release of mature interleukin-33 (IL33), promoting type 2 inflammatory immune response (PubMed:35794369, PubMed:35749514). [Gasdermin-D]: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C- terminal domains mediate autoinhibition in the absence of activation signal (PubMed:26375003, PubMed:26375259, PubMed:26611636, PubMed:29576317, PubMed:31097341). The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-D, N- terminal) following cleavage by inflammatory caspases CASP1, CASP4/CASP11 or CASP8 (PubMed:26375003, PubMed:26375259, PubMed:26611636, PubMed:30361383, PubMed:30381458, PubMed:32554464, PubMed:32553275). Cleavage at Asp-88 by CASP3 or CAPS7 inactivates the ability to mediate pyroptosis (By similarity). [Gasdermin-D, N-terminal]: Homooligomer; homooligomeric ring- shaped pore complex containing 27-28 subunits when inserted in the membrane (PubMed:34289345). Homooligomerization is promoted by the mTORC1 complex in macrophages (PubMed:34289345). In response to a canonical inflammasome stimulus, such as nigericin, recruited to NLRP3 inflammasone with similar kinetics to that of uncleaved CASP1 precursor (PubMed:26611636). Although this recruitment is also observed in the absence of PYCARD, it is more efficient in its presence (PubMed:26611636). [Gasdermin-D]: Cytoplasm, cytosol Inflammasome Note=In response to a canonical inflammasome stimulus, such as nigericin, recruited to NLRP3 inflammasone with similar kinetics to that of uncleaved CASP1 precursor. [Gasdermin-D, N-terminal]: Cell membrane ulti-pass membrane protein Secreted Mitochondrion membrane Note=Released in the extracellular milieu following pyroptosis (PubMed:27383986). Mitochondrial localization results in release of mitochondrial DNA into the cytosol (PubMed:37001519). [Gasdermin-D, N-terminal]: Cytoplasm, cytosol Note=(Microbial infection) Upon infection by M.tuberculosis, localization to cell membrane is prevented by M.tuberculosis phosphatase PtpB that catalyzes dephosphorylation of phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol 4- phosphate, thereby inhibiting the membrane targeting of Gasdermin-D, N- terminal and subsequent cytokine release and pyroptosis. [Gasdermin-D, p13]: Nucleus [Gasdermin-D, C-terminal]: Cytoplasm, cytosol Expression starts at 8.5 dpc and increases from 13.5 dpc on. Still detected after birth. Intramolecular interactions between N- and C-terminal domains mediate autoinhibition in the absence of cleavage by inflammatory caspases CASP1 or CASP4/CASP11 (PubMed:26375003, PubMed:26375259, PubMed:26611636, PubMed:29576317, PubMed:31097341). The linker helix loop inserts into the N-terminal domain (By similarity). The intrinsic pyroptosis-inducing activity is carried by Gasdermin-D, N-terminal, that is released upon cleavage by inflammatory caspases (PubMed:26375003, PubMed:26375259, PubMed:26611636). [Gasdermin-D, N-terminal]: Forms a ring-shaped pore complex containing 27-28 subunits that inserts into the membrane. The pore conduit is predominantly negatively charged, facilitating the release of mature interleukin-1 (IL1B and IL18). In contrast interleukin-1 precursors are not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. Cleavage at Asp-276 by CASP1 (mature and uncleaved precursor forms), CASP4/CASP11 or CASP8 relieves autoinhibition and is sufficient to initiate pyroptosis (PubMed:26375259, PubMed:26611636, PubMed:32554464, PubMed:32553275). Cleavage by CASP1 and CASP4/CASP11 is not strictly dependent on the consensus cleavage site on GSDMD but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32554464, PubMed:32553275). Cleavage by CASP8 takes place following inactivation of MAP3K7/TAK1 by Yersinia toxin YopJ (PubMed:30361383, PubMed:30381458). Cleavage at Asp-88 by CASP3 or CAPS7 inactivates the ability to mediate pyroptosis, but generates the Gasdermin-D, p13 chain, which translocates to the nucleus and acts as a transcription regulator (PubMed:37327784). Cleavage by papain allergen generates the Gasdermin-D, p40 chain (PubMed:35794369). [Gasdermin-D]: Succination of Cys-192 by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits processing by caspases, and ability to initiate pyroptosis (PubMed:32820063). Succination modification is catalyzed by a non- enzymatic reaction caused by an accumulation of fumarate (PubMed:32820063). Knockout mice are born at the expected Mendelian rate and do not exhibit any overt phenotype in normal housing conditions. The gastrointestinal tract develops normally. They are however resistant to LPS-induced lethal septic shock. Primary bone marrow-derived macrophages fail to undergo pyroptosis in response to canonical (acting via CASP1), as well as to non-canonical (acting via CASP4) inflammasome activators. CASP1-mediated IL1B release is also impaired, but not CASP1 autoprocessing, nor IL1B maturation. Belongs to the gasdermin family. phosphatidylserine binding immune system process phosphatidylinositol-4,5-bisphosphate binding extracellular region extracellular space nucleoplasm cytoplasm cytosol plasma membrane inflammatory response programmed cell death membrane cytolysis cellular response to extracellular stimulus pore formation in membrane of other organism innate immune response pore complex assembly positive regulation of interleukin-1 beta secretion defense response to Gram-negative bacterium defense response to Gram-positive bacterium protein homooligomerization inflammasome complex pyroptosis phosphatidylinositol-4-phosphate binding phosphatidic acid binding NLRP3 inflammasome complex cardiolipin binding uc007whh.1 uc007whh.2 uc007whh.3 
ENSMUST00000023243.11 Gpihbp1 ENSMUST00000023243.11 GPI-anchored HDL-binding protein 1, transcript variant 1 (from RefSeq NM_026730.2) ENSMUST00000023243.1 ENSMUST00000023243.10 ENSMUST00000023243.2 ENSMUST00000023243.3 ENSMUST00000023243.4 ENSMUST00000023243.5 ENSMUST00000023243.6 ENSMUST00000023243.7 ENSMUST00000023243.8 ENSMUST00000023243.9 Gpihbp1 HDBP1_MOUSE Hbp1 NM_026730 Q9D1N2 uc007wgw.1 uc007wgw.2 uc007wgw.3 Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (PubMed:20620994). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (PubMed:20620994, PubMed:24726386, PubMed:27811232). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:17403372). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:18340083). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (PubMed:12496272). Mostly monomer, but also homodimer and homooligomer (PubMed:25387803). Interacts with lipoprotein lipase (LPL) (PubMed:17403372, PubMed:18340083, PubMed:19304573, PubMed:20620994, PubMed:25387803, PubMed:24726386, PubMed:27811232). Interacts with high affinity with high-density lipoprotein (HDL) (PubMed:12496272). Interacts with chylomicrons (PubMed:17403372). Interacts with APOA5 (PubMed:18340083). Apical cell membrane ; Lipid-anchor, GPI-anchor solateral cell membrane ; Lipid-anchor, GPI-anchor ll membrane ipid- anchor, GPI-anchor Detected in fat tissue (PubMed:18340083, PubMed:17403372). Detected on the luminal surface of capillary endothelial cells in heart, skeletal muscle and brown adipose tissue (at protein level) (PubMed:17403372, PubMed:20620994). Detected in heart and brown adipose tissue (PubMed:12496272, PubMed:17403372). Expressed at lower levels in lung and liver (PubMed:12496272). Induced by fasting. The N-terminal acidic region is intrinsically disordered (By similarity). This region contributes to LPL binding (PubMed:20620994). It stabilizes LPL and protects LPL against loss of activity (By similarity). Glycosylation of Asn-76 is critical for cell surface localization. Sulfation of a Tyr in the N-terminal acidic region increases the affinity for LPL. Adult mice display chylomicronemia when kept on a normal chow diet, with milky-looking blood plasma due to marked accumulation of chylomicrons in the plasma. Their plasma triglyceride levels are generally above 1000 mg/dl and can be as high as 5000 mg/dl. Mice display decreased plasma levels of lipoprotein lipase LPL (PubMed:17403372). Contrary to wild-type, LPL is not recruited to the apical surface of endothelial cell that faces the lumen of capillaries, but is mislocalized to the interstitial spaces surrounding myocytes and adipocytes (PubMed:20620994, PubMed:24726386, PubMed:27811232). plasma membrane lipid transport intracellular protein transport high-density lipoprotein particle binding lipid binding external side of plasma membrane cell surface membrane basolateral plasma membrane apical plasma membrane protein import acetylcholine receptor inhibitor activity anchored component of membrane protein localization to cell surface lipase binding chylomicron binding cholesterol homeostasis transcytosis anchored component of plasma membrane protein stabilization positive regulation of lipoprotein lipase activity triglyceride homeostasis lipoprotein particle binding positive regulation of chylomicron remodeling positive regulation of chylomicron remnant clearance negative regulation of receptor activity cholesterol transport uc007wgw.1 uc007wgw.2 uc007wgw.3 
ENSMUST00000023247.13 Ly6f ENSMUST00000023247.13 lymphocyte antigen 6 family member F (from RefSeq NM_008530.2) ENSMUST00000023247.1 ENSMUST00000023247.10 ENSMUST00000023247.11 ENSMUST00000023247.12 ENSMUST00000023247.2 ENSMUST00000023247.3 ENSMUST00000023247.4 ENSMUST00000023247.5 ENSMUST00000023247.6 ENSMUST00000023247.7 ENSMUST00000023247.8 ENSMUST00000023247.9 LY6F_MOUSE NM_008530 P35460 uc007wgs.1 uc007wgs.2 Cell membrane ; Lipid-anchor, GPI- anchor cellular_component plasma membrane membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway negative regulation of receptor activity uc007wgs.1 uc007wgs.2 
ENSMUST00000023250.11 Ly6i ENSMUST00000023250.11 lymphocyte antigen 6 family member I, transcript variant 1 (from RefSeq NM_020498.3) ENSMUST00000023250.1 ENSMUST00000023250.10 ENSMUST00000023250.2 ENSMUST00000023250.3 ENSMUST00000023250.4 ENSMUST00000023250.5 ENSMUST00000023250.6 ENSMUST00000023250.7 ENSMUST00000023250.8 ENSMUST00000023250.9 LY6I_MOUSE Ly6m NM_020498 Q05AA4 Q9WU67 uc007wgj.1 uc007wgj.2 uc007wgj.3 uc007wgj.4 Cell membrane ; Lipid-anchor, GPI- anchor Expressed in hematopoietic tissue (spleen, thymus, bone marrow). Also found in peritoneal macrophages, peripheral blood leukocytes, liver, heart, brain, kidney and lung. Ly-6I.2 and Ly-6I.1 are expressed in bone marrow of strain C57BL/6 and strain NOD, respectively. plasma membrane membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway negative regulation of receptor activity uc007wgj.1 uc007wgj.2 uc007wgj.3 uc007wgj.4 
ENSMUST00000023259.15 Lynx1 ENSMUST00000023259.15 Ly6/neurotoxin 1 (from RefSeq NM_011838.4) ENSMUST00000023259.1 ENSMUST00000023259.10 ENSMUST00000023259.11 ENSMUST00000023259.12 ENSMUST00000023259.13 ENSMUST00000023259.14 ENSMUST00000023259.2 ENSMUST00000023259.3 ENSMUST00000023259.4 ENSMUST00000023259.5 ENSMUST00000023259.6 ENSMUST00000023259.7 ENSMUST00000023259.8 ENSMUST00000023259.9 LYNX1_MOUSE Lynx1 NM_011838 P0DP60 Q08EF7 Q3TRB5 Q9WVC2 uc007wfw.1 uc007wfw.2 uc007wfw.3 Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:10402197). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs (PubMed:10402197, PubMed:11906696). Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta- 2(2) nAChR (PubMed:25193667). In vitro modulates alpha-3:beta-4- containing nAChRs. Reduces cell surface expression of (alpha-3:beta- 4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (PubMed:21071629). Interacts with nAChRs containing alpha-4:beta-2 (CHRNA4:CHRNB2) and alpha-7 (CHRNA7) subunits (PubMed:11906696). Interacts with CHRNA4 probably in the endoplasmic reticulum prior to nAChR pentameric assembly (PubMed:19468303). Cell membrane ; Lipid-anchor, GPI- anchor Cell projection, dendrite Endoplasmic reticulum Note=Detected in Purkinje cells soma and proximal dendrites. Expressed in neurons of multiple regions in the CNS, including the cerebral cortex, thalamus, substantia nigra, cerebellum, amygdala and hippocampus (PubMed:10402197, PubMed:11906696). Also expressed in kidney, heart and thymus, but at lower levels than in the brain (PubMed:10402197). Expressed in the primary visual cortex (V1) and the lateral geniculate nucleus (at protein level) (PubMed:21071629). Expressed at very low levels at birth and undergoes a marked up-regulation between postnatal days 10 and 20 (PubMed:10402197). Up-regulated in the visual cortex between postnatal day 28 (P28) and P60, when experience-dependent brain plasticity declines (PubMed:21071629). Mutant mice show no gross abnormalities in size, viability, CNS morphology or longevity, but demonstrate enhanced performance in learning ability and memory and are more responsive to nicotine. Aging mutant mice exhibit a vacuolating neurodegeneration that is exacerbated by nicotine. protein binding endoplasmic reticulum plasma membrane synaptic transmission, cholinergic ion channel inhibitor activity membrane dendrite acetylcholine receptor regulator activity acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding cell projection regulation of neurotransmitter receptor activity negative regulation of receptor activity uc007wfw.1 uc007wfw.2 uc007wfw.3 
ENSMUST00000023260.5 Lypd2 ENSMUST00000023260.5 Ly6/Plaur domain containing 2 (from RefSeq NM_026671.1) A2RT83 ENSMUST00000023260.1 ENSMUST00000023260.2 ENSMUST00000023260.3 ENSMUST00000023260.4 LYPD2_MOUSE Lypdc2 NM_026671 Q9DD23 uc007wfu.1 uc007wfu.2 uc007wfu.3 Cell membrane ; Lipid-anchor, GPI- anchor molecular_function plasma membrane membrane anchored component of membrane uc007wfu.1 uc007wfu.2 uc007wfu.3 
ENSMUST00000023265.5 Psca ENSMUST00000023265.5 prostate stem cell antigen (from RefSeq NM_028216.2) ENSMUST00000023265.1 ENSMUST00000023265.2 ENSMUST00000023265.3 ENSMUST00000023265.4 NM_028216 P57096 PSCA_MOUSE Q9D7U0 uc007wfr.1 uc007wfr.2 uc007wfr.3 uc007wfr.4 May be involved in the regulation of cell proliferation. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. Interacts with CHRNA4. Cell membrane ; Lipid-anchor, GPI-anchor Predominantly expressed in prostate. Also found in spleen, liver, lung, prostate, kidney and testis. Expressed in brain cortex; expression is increased in transgenic mouse model of Alzheimer disease (at protein level). plasma membrane membrane anchored component of membrane acetylcholine receptor binding negative regulation of ERK1 and ERK2 cascade regulation of neurotransmitter receptor activity uc007wfr.1 uc007wfr.2 uc007wfr.3 uc007wfr.4 
ENSMUST00000023269.5 Rpl24 ENSMUST00000023269.5 ribosomal protein L24 (from RefSeq NM_024218.4) ENSMUST00000023269.1 ENSMUST00000023269.2 ENSMUST00000023269.3 ENSMUST00000023269.4 NM_024218 P38663 Q58EA4 Q8BP67 RL24_MOUSE uc007zlv.1 uc007zlv.2 uc007zlv.3 uc007zlv.4 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Cytoplasm Mono-ADP-ribosylation at Glu-4 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation. Belongs to the eukaryotic ribosomal protein eL24 family. Sequence=AAH02110.2; Type=Erroneous initiation; Evidence=; ribosomal large subunit assembly cytoplasmic translation RNA binding structural constituent of ribosome cytoplasm endoplasmic reticulum cytosol ribosome translation mitotic cell cycle checkpoint exit from mitosis optic nerve development cytosolic large ribosomal subunit cytosolic ribosome retinal ganglion cell axon guidance polysomal ribosome synapse retina development in camera-type eye assembly of large subunit precursor of preribosome uc007zlv.1 uc007zlv.2 uc007zlv.3 uc007zlv.4 
ENSMUST00000023270.14 Cep97 ENSMUST00000023270.14 centrosomal protein 97, transcript variant 1 (from RefSeq NM_028815.4) CEP97_MOUSE ENSMUST00000023270.1 ENSMUST00000023270.10 ENSMUST00000023270.11 ENSMUST00000023270.12 ENSMUST00000023270.13 ENSMUST00000023270.2 ENSMUST00000023270.3 ENSMUST00000023270.4 ENSMUST00000023270.5 ENSMUST00000023270.6 ENSMUST00000023270.7 ENSMUST00000023270.8 ENSMUST00000023270.9 Lrriq2 NM_028815 Q8BL35 Q9CZ62 uc007zlr.1 uc007zlr.2 uc007zlr.3 uc007zlr.4 Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome (By similarity). Interacts with CALM1, CEP76, KIF24 and TALPID3 (By similarity). Interacts with CCP110 (PubMed:35301795). ENKD1 competes with CEP97 for binding to CCP110, destabilizing the interaction between CP110 and CEP97 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (PubMed:35301795). Via its interaction with CCP110, may indirectly interact with HERC2 and NEURL4 (By similarity). Interacts with MPHOSPH9 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Recruited at the distal end of the mother centriole by MPHOSPH9. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZ62-1; Sequence=Displayed; Name=2; IsoId=Q9CZ62-2; Sequence=VSP_021883; Sequence=BAC32752.1; Type=Frameshift; Evidence=; molecular_function cytoplasm centrosome microtubule organizing center cytosol cytoskeleton cell projection organization macromolecular complex regulation of mitotic spindle assembly negative regulation of cilium assembly uc007zlr.1 uc007zlr.2 uc007zlr.3 uc007zlr.4 
ENSMUST00000023282.9 Miox ENSMUST00000023282.9 myo-inositol oxygenase (from RefSeq NM_019977.2) Aldrl6 ENSMUST00000023282.1 ENSMUST00000023282.2 ENSMUST00000023282.3 ENSMUST00000023282.4 ENSMUST00000023282.5 ENSMUST00000023282.6 ENSMUST00000023282.7 ENSMUST00000023282.8 MIOX_MOUSE NM_019977 Q5S8D0 Q91WQ8 Q9QXN5 Rsor uc007xgc.1 uc007xgc.2 uc007xgc.3 Reaction=myo-inositol + O2 = D-glucuronate + H(+) + H2O; Xref=Rhea:RHEA:23696, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17268, ChEBI:CHEBI:58720; EC=1.13.99.1; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Note=Binds 2 iron ions per subunit. Polyol metabolism; myo-inositol degradation into D- glucuronate; D-glucuronate from myo-inositol: step 1/1. Cytoplasm Kidney specific. Renal proximal tubules. Belongs to the myo-inositol oxygenase family. aldo-keto reductase (NADP) activity iron ion binding cytoplasm ferric iron binding inclusion body oxidoreductase activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on single donors with incorporation of molecular oxygen inositol catabolic process metal ion binding inositol oxygenase activity NADP binding oxidation-reduction process uc007xgc.1 uc007xgc.2 uc007xgc.3 
ENSMUST00000023283.6 Lmf2 ENSMUST00000023283.6 lipase maturation factor 2, transcript variant 1 (from RefSeq NM_178919.5) ENSMUST00000023283.1 ENSMUST00000023283.2 ENSMUST00000023283.3 ENSMUST00000023283.4 ENSMUST00000023283.5 LMF2_MOUSE NM_178919 Q8C3X8 Tmem112b Tmem153 uc007xgd.1 uc007xgd.2 uc007xgd.3 Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the lipase maturation factor family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane protein maturation uc007xgd.1 uc007xgd.2 uc007xgd.3 
ENSMUST00000023285.5 Tymp ENSMUST00000023285.5 thymidine phosphorylase (from RefSeq NM_138302.3) ENSMUST00000023285.1 ENSMUST00000023285.2 ENSMUST00000023285.3 ENSMUST00000023285.4 Ecgf1 NM_138302 Q99N42 TYPH_MOUSE uc007xgl.1 uc007xgl.2 uc007xgl.3 uc007xgl.4 uc007xgl.5 Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity). Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.4; Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. mitochondrial genome maintenance phosphorylase activity cytosol pyrimidine nucleobase metabolic process pyrimidine nucleoside metabolic process chemotaxis thymidine phosphorylase activity animal organ morphogenesis pyrimidine-nucleoside phosphorylase activity transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups regulation of myelination protein homodimerization activity regulation of transmission of nerve impulse regulation of gastric motility uc007xgl.1 uc007xgl.2 uc007xgl.3 uc007xgl.4 uc007xgl.5 
ENSMUST00000023289.13 Chkb ENSMUST00000023289.13 choline kinase beta, transcript variant 3 (from RefSeq NR_037154.1) Chetk-beta Chkb ENSMUST00000023289.1 ENSMUST00000023289.10 ENSMUST00000023289.11 ENSMUST00000023289.12 ENSMUST00000023289.2 ENSMUST00000023289.3 ENSMUST00000023289.4 ENSMUST00000023289.5 ENSMUST00000023289.6 ENSMUST00000023289.7 ENSMUST00000023289.8 ENSMUST00000023289.9 NR_037154 Q54AG5 Q54AG5_MOUSE uc007xgs.1 uc007xgs.2 uc007xgs.3 uc007xgs.4 Lipid metabolism. Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. Belongs to the choline/ethanolamine kinase family. choline kinase activity ethanolamine kinase activity phosphatidylethanolamine biosynthetic process CDP-choline pathway kinase activity phosphorylation glycerophospholipid biosynthetic process uc007xgs.1 uc007xgs.2 uc007xgs.3 uc007xgs.4 
ENSMUST00000023291.6 Mapk8ip2 ENSMUST00000023291.6 mitogen-activated protein kinase 8 interacting protein 2 (from RefSeq NM_021921.3) ENSMUST00000023291.1 ENSMUST00000023291.2 ENSMUST00000023291.3 ENSMUST00000023291.4 ENSMUST00000023291.5 Ib2 JIP2_MOUSE Jip2 NM_021921 Q9CXI4 Q9ERE9 uc007xgx.1 uc007xgx.2 uc007xgx.3 uc007xgx.4 The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells (By similarity). Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely JNK1, JNK2, JNK3, MAP2K7, MAP3K10, MAP3K11, MAP3K12 and MAPK13 (By similarity). Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Binds the TPR motif-containing C- terminal of kinesin light chain. Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Interacts with DCLK2. Interacts with FGF13; enables the interaction with MAPK13 and may regulate the MAPK8IP2 scaffolding activity. Interacts with TIAM1 and TIAM2 (PubMed:10827199, PubMed:11378392, PubMed:16628014, PubMed:19893486). Interacts with SH3RF2 (By similarity). Q9ERE9; Q91ZX7: Lrp1; NbExp=2; IntAct=EBI-74576, EBI-300955; Q9ERE9; A2ARV4: Lrp2; NbExp=2; IntAct=EBI-74576, EBI-300875; Q9ERE9; P14599: Appl; Xeno; NbExp=2; IntAct=EBI-74576, EBI-74135; Cytoplasm Note=Accumulates in cell surface projections. Highly expressed in brain. Expressed in all neurons. Also expressed in testis, primarily in the epididymal epidermis. Upon neuron differentiation. Belongs to the JIP scaffold family. Sequence=AK014339; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; MAPK cascade behavioral fear response MAP-kinase scaffold activity protein binding cytoplasm plasma membrane receptor-mediated endocytosis JNK cascade mating behavior regulation of receptor activity postsynaptic density kinesin binding protein kinase binding protein kinase activator activity activation of protein kinase activity positive regulation of stress-activated MAPK cascade macromolecular complex social behavior neuronal cell body macromolecular complex binding positive regulation of endocytosis regulation of JNK cascade nonassociative learning dendrite morphogenesis regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential negative regulation of canonical Wnt signaling pathway regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity negative regulation of apoptotic signaling pathway uc007xgx.1 uc007xgx.2 uc007xgx.3 uc007xgx.4 
ENSMUST00000023294.15 Rabl2 ENSMUST00000023294.15 RAB, member RAS oncogene family-like 2 (from RefSeq NM_026817.3) E9Q9D5 ENSMUST00000023294.1 ENSMUST00000023294.10 ENSMUST00000023294.11 ENSMUST00000023294.12 ENSMUST00000023294.13 ENSMUST00000023294.14 ENSMUST00000023294.2 ENSMUST00000023294.3 ENSMUST00000023294.4 ENSMUST00000023294.5 ENSMUST00000023294.6 ENSMUST00000023294.7 ENSMUST00000023294.8 ENSMUST00000023294.9 NM_026817 Q3TDG7 Q8K2P9 Q9D133 RBL2A_MOUSE Rabl2a uc007xhf.1 uc007xhf.2 uc007xhf.3 Plays an essential role in male fertility, sperm intra- flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail. Interacts with IFT27, IFT81, IFT172, ATP6V1E1, HK1, LDHC, MAPRE1 and HSPA2. Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=E9Q9D5-2; Sequence=Displayed; Name=1; IsoId=E9Q9D5-1; Sequence=VSP_053488, VSP_053489; Name=3; IsoId=E9Q9D5-3; Sequence=VSP_053487; Isoform 2 is expressed in the testis and localizes to the mid-piece of the sperm tail (at protein level). Isoform 2 is expressed at higher levels in testis than isoform 1. Isoform 1 and isoform 2 are widely expressed and notably within other tissues containing motile cilia including the lung, trachea, brain, ovary and kidney. Exhibits phenotypes characteristic of ciliopathies. Pre-axial polydactyly. Retinal degeneration, characterized by loss of the outer nuclear layer that contains the cell body of photoreceptor cells. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity protein binding GTP binding intracellular protein transport single fertilization photoreceptor cell morphogenesis flagellated sperm motility intraciliary transport particle B Rab protein signal transduction cilium assembly sperm midpiece uc007xhf.1 uc007xhf.2 uc007xhf.3 
ENSMUST00000023295.3 Acr ENSMUST00000023295.3 acrosin prepropeptide, transcript variant 1 (from RefSeq NM_013455.4) ACRO_MOUSE ENSMUST00000023295.1 ENSMUST00000023295.2 NM_013455 P23578 uc007xhc.1 uc007xhc.2 uc007xhc.3 Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.10; Inhibited by SERPINA5. Heavy chain (catalytic) and a light chain linked by two disulfide bonds. Forms a heterodimer with SERPINA5 (By similarity). Belongs to the peptidase S1 family. Sequence=AAA40124.1; Type=Erroneous initiation; Evidence=; Sequence=BAA00651.1; Type=Erroneous initiation; Evidence=; Sequence=CAA36704.1; Type=Erroneous initiation; Evidence=; acrosomal vesicle acrosome matrix dispersal amidase activity serine-type endopeptidase activity protein binding mannose binding Golgi-associated vesicle proteolysis activation of adenylate cyclase activity single fertilization binding of sperm to zona pellucida acrosome reaction penetration of zona pellucida drug binding peptidase activity serine-type peptidase activity hydrolase activity protein catabolic process macromolecular complex fucose binding acrosomal matrix response to steroid hormone uc007xhc.1 uc007xhc.2 uc007xhc.3 
ENSMUST00000023328.8 Retnlb ENSMUST00000023328.8 resistin like beta (from RefSeq NM_023881.4) A0A0R4J042 A0A0R4J042_MOUSE ENSMUST00000023328.1 ENSMUST00000023328.2 ENSMUST00000023328.3 ENSMUST00000023328.4 ENSMUST00000023328.5 ENSMUST00000023328.6 ENSMUST00000023328.7 NM_023881 Retnlb uc007zju.1 uc007zju.2 Secreted Belongs to the resistin/FIZZ family. hormone activity extracellular region signal transduction uc007zju.1 uc007zju.2 
ENSMUST00000023330.8 Morc1 ENSMUST00000023330.8 microrchidia 1 (from RefSeq NM_010816.1) ENSMUST00000023330.1 ENSMUST00000023330.2 ENSMUST00000023330.3 ENSMUST00000023330.4 ENSMUST00000023330.5 ENSMUST00000023330.6 ENSMUST00000023330.7 MORC1_MOUSE Morc Morc1 NM_010816 Q9WVL5 uc007zjp.1 uc007zjp.2 uc007zjp.3 Required for spermatogenesis (PubMed:10369865, PubMed:25503965). Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (PubMed:25503965). Not required for piRNA biosynthesis (PubMed:25503965). Nucleus Expressed at very low level in male germ cells. Detected in embryonic testis at embryonic days 14.5 dpc and peaks at 16.5 dpc. Mice show progressive loss of spermatogonia and male infertility (PubMed:10369865, PubMed:25503965). Spermatogenesis is blocked early in meiosis I (PubMed:10369865, PubMed:25503965). Male germ cells show derepression of transposable elements (TEs) and DNA hypomethylation of TEs (PubMed:25503965). Mice display increased depressive-like behavior whereas no behavioral abnormalities regarding locomotor activity or anxiety-like behavior are detectable and BDNF levels in the hippocampus are up-regulated (PubMed:26275923). behavioral fear response male germ cell nucleus molecular_function nucleus multicellular organism development spermatogenesis zinc ion binding negative regulation of transposition negative regulation of gene expression cell differentiation regulation of gene expression, epigenetic DNA methylation involved in gamete generation DNA hypermethylation metal ion binding negative regulation of DNA-templated transcription, initiation uc007zjp.1 uc007zjp.2 uc007zjp.3 
ENSMUST00000023334.15 Nectin3 ENSMUST00000023334.15 nectin cell adhesion molecule 3, transcript variant alpha (from RefSeq NM_021495.4) ENSMUST00000023334.1 ENSMUST00000023334.10 ENSMUST00000023334.11 ENSMUST00000023334.12 ENSMUST00000023334.13 ENSMUST00000023334.14 ENSMUST00000023334.2 ENSMUST00000023334.3 ENSMUST00000023334.4 ENSMUST00000023334.5 ENSMUST00000023334.6 ENSMUST00000023334.7 ENSMUST00000023334.8 ENSMUST00000023334.9 NECT3_MOUSE NM_021495 Nectin3 Pvrl3 Q059N7 Q9D006 Q9JLB7 Q9JLB8 Q9JLB9 uc007zjk.1 uc007zjk.2 uc007zjk.3 uc007zjk.4 uc007zjk.5 Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans- interaction with NECTIN2 at Sertoli-spermatid junctions. Trans- interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. Cis- and trans-homodimer. Can form trans-heterodimers with NECTIN1, NECTIN2, PVR, IGSF4B/Necl-1 and with IGSF4. Interaction between NECTIN1 and NECTIN3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Cytoplasmic domain) with AFDN, providing a connection with the actin cytoskeleton. Binds with low affinity to TIGIT. Cell membrane ; Single-pass membrane protein Postsynaptic cell membrane Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Nectin-3 alpha; IsoId=Q9JLB9-1; Sequence=Displayed; Name=2; Synonyms=Nectin-3 beta; IsoId=Q9JLB9-2; Sequence=VSP_017437, VSP_017440; Name=3; Synonyms=Nectin-3 gamma; IsoId=Q9JLB9-3; Sequence=VSP_017438, VSP_017439; Ubiquitous with high expression in testes. Localized in spermatids at Sertoli-spermatid junctions. Expressed in ovarian granulosa cells, but only faintly expressed after ovulation. Mice show an ocular phenotype, microphthalmia, accompanied by a separation of the contact between the pigment and non- pigment cell layers of the ciliary epithelia. Male mice exhibits infertility, suggesting a role in spermatogenesis. In the hippocampus, the formation and the number of adherens junctions at the synapses is impaired, and the trajectory of mossy fiber is abnormal. Belongs to the nectin family. lens morphogenesis in camera-type eye protein binding plasma membrane cell-cell junction cell-cell adherens junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules spermatid development fertilization membrane integral component of membrane cell junction axon dendrite signaling receptor activity identical protein binding protein homodimerization activity apical junction complex cell-cell contact zone synapse postsynaptic membrane cell adhesion molecule binding retina morphogenesis in camera-type eye cell-cell adhesion integral component of postsynaptic density membrane protein localization to cell junction uc007zjk.1 uc007zjk.2 uc007zjk.3 uc007zjk.4 uc007zjk.5 
ENSMUST00000023336.10 Cd96 ENSMUST00000023336.10 CD96 antigen (from RefSeq NM_032465.2) ENSMUST00000023336.1 ENSMUST00000023336.2 ENSMUST00000023336.3 ENSMUST00000023336.4 ENSMUST00000023336.5 ENSMUST00000023336.6 ENSMUST00000023336.7 ENSMUST00000023336.8 ENSMUST00000023336.9 NM_032465 Q3U0X8 Q7TMW0 Q8C9U6 Q99M67 TACT_MOUSE uc007zjf.1 uc007zjf.2 uc007zjf.3 uc007zjf.4 May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation (By similarity). Homodimer; disulfide-linked. Interacts with PVR (By similarity). Membrane ; Single-pass type I membrane protein cytokine production involved in inflammatory response negative regulation of natural killer cell cytokine production protein binding cytoplasm adherens junction cell adhesion cell-matrix adhesion membrane integral component of membrane response to lipopolysaccharide negative regulation of interferon-gamma production uc007zjf.1 uc007zjf.2 uc007zjf.3 uc007zjf.4 
ENSMUST00000023341.15 Cd200 ENSMUST00000023341.15 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein (from UniProt E9QMY1) BC051984 Cd200 E9QMY1 E9QMY1_MOUSE ENSMUST00000023341.1 ENSMUST00000023341.10 ENSMUST00000023341.11 ENSMUST00000023341.12 ENSMUST00000023341.13 ENSMUST00000023341.14 ENSMUST00000023341.2 ENSMUST00000023341.3 ENSMUST00000023341.4 ENSMUST00000023341.5 ENSMUST00000023341.6 ENSMUST00000023341.7 ENSMUST00000023341.8 ENSMUST00000023341.9 uc289evt.1 uc289evt.2 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein membrane integral component of membrane negative regulation of macrophage activation regulation of immune response uc289evt.1 uc289evt.2 
ENSMUST00000023343.4 Atg3 ENSMUST00000023343.4 autophagy related 3, transcript variant 1 (from RefSeq NM_026402.3) ATG3_MOUSE Apg3l ENSMUST00000023343.1 ENSMUST00000023343.2 ENSMUST00000023343.3 NM_026402 Q3TXJ9 Q9CPX6 uc007zii.1 uc007zii.2 uc007zii.3 E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8- phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. ATG12-ATG3 conjugate is also formed upon viccina virus infection, leading to the disruption the cellular autophagy which is not necessary for vaccinia survival and proliferation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Interacts with ATG7 and ATG12. The complex composed of ATG3 and ATG7 plays a role in the conjugation of ATG12 to ATG5. Interacts with FNBP1L (By similarity). Q9CPX6; Q9CQY1: Atg12; NbExp=5; IntAct=EBI-2911810, EBI-2911788; Cytoplasm Conjugated to ATG12 at Lys-243. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy. Cleaved by CASP8 upon death ligand binding such as tumor necrosis factor-alpha. CASP8 cleavage blocks survival-related autophagy and favors apoptosis (By similarity). Belongs to the ATG3 family. autophagosome assembly cytoplasmic ubiquitin ligase complex mitophagy protein binding cytoplasm cytosol cellular protein modification process autophagy protein transport macroautophagy protein ubiquitination transferase activity Atg8 ligase activity Atg12 transferase activity ubiquitin-like protein transferase activity enzyme binding mitochondrial fragmentation involved in apoptotic process negative regulation of phagocytosis regulation of cilium assembly uc007zii.1 uc007zii.2 uc007zii.3 
ENSMUST00000023344.10 Slc35a5 ENSMUST00000023344.10 solute carrier family 35, member A5, transcript variant 1 (from RefSeq NM_028756.4) ENSMUST00000023344.1 ENSMUST00000023344.2 ENSMUST00000023344.3 ENSMUST00000023344.4 ENSMUST00000023344.5 ENSMUST00000023344.6 ENSMUST00000023344.7 ENSMUST00000023344.8 ENSMUST00000023344.9 NM_028756 Q921R7 Q9DC72 S35A5_MOUSE Slc35a5 uc007zih.1 uc007zih.2 uc007zih.3 uc007zih.4 Probable UDP-sugar:UMP transmembrane antiporter involved in UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D- glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport from the cytosol to the lumen of the Golgi. Reaction=UDP-alpha-D-glucuronate(in) + UMP(out) = UDP-alpha-D- glucuronate(out) + UMP(in); Xref=Rhea:RHEA:72727, ChEBI:CHEBI:57865, ChEBI:CHEBI:58052; Evidence=; Reaction=UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) = UDP-N- acetyl-alpha-D-glucosamine(out) + UMP(in); Xref=Rhea:RHEA:72695, ChEBI:CHEBI:57705, ChEBI:CHEBI:57865; Evidence=; Reaction=UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) = UDP-N- acetyl-alpha-D-galactosamine(out) + UMP(in); Xref=Rhea:RHEA:72735, ChEBI:CHEBI:57865, ChEBI:CHEBI:67138; Evidence=; Probably forms homooligomers and heterooligomers with SLC35A1, SLC35A2, SLC35A3 and SLC35A4. Golgi apparatus membrane ; Multi-pass membrane protein Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. It is uncertain whether Met-1 or Met-14 is the initiator. Golgi membrane Golgi apparatus carbohydrate transport pyrimidine nucleotide-sugar transmembrane transporter activity membrane integral component of membrane integral component of Golgi membrane pyrimidine nucleotide-sugar transmembrane transport uc007zih.1 uc007zih.2 uc007zih.3 uc007zih.4 
ENSMUST00000023352.9 Prkdc ENSMUST00000023352.9 protein kinase, DNA activated, catalytic polypeptide (from RefSeq NM_011159.2) E9QN15 ENSMUST00000023352.1 ENSMUST00000023352.2 ENSMUST00000023352.3 ENSMUST00000023352.4 ENSMUST00000023352.5 ENSMUST00000023352.6 ENSMUST00000023352.7 ENSMUST00000023352.8 NM_011159 O88187 P97313 P97928 PRKDC_MOUSE Q307W9 Q3V2W8 Q8C2A7 Q9Z341 Xrcc7 uc007yht.1 uc007yht.2 uc007yht.3 Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (By similarity). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (By similarity). Must be bound to DNA to express its catalytic properties (By similarity). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (By similarity). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (By similarity). Act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (By similarity). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (By similarity). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (PubMed:12426399). Also involved in modulation of transcription (By similarity). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (By similarity). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (By similarity). Recognizes the substrate consensus sequence [ST]-Q (By similarity). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (By similarity). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (By similarity). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (By similarity). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (By similarity). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser- 588' and increasing CRY1 protein stability, most likely through an indirect mechanism (PubMed:24158435). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP- RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (By similarity). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Activity seems to be attenuated by autophosphorylation. Binding to the SL1 region of U3 small nucleolar RNA promotes auto-phosphorylation activity. Inhibited by wortmannin. DNA-PK is a heterotrimer of PRKDC and the Ku dimer (composed of XRCC6/Ku70 and XRCC5/Ku86). Formation of this complex may be promoted by interaction with ILF3. Component of the core long-range non-homologous end joining (NHEJ) complex (also named DNA-PK complex) composed of PRKDC, LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF. Additional component of the NHEJ complex includes PAXX. Following autophosphorylation, PRKDC dissociates from DNA. Interacts with DNA- PKcs-interacting protein (KIP) with the region upstream the kinase domain. PRKDC alone also interacts with and phosphorylates DCLRE1C, thereby activating the latent endonuclease activity of this protein. Interacts with C1D. Interacts with TTI1 and TELO2. Interacts with CIB1. Interacts with SETX. Interacts with NR4A3; the DNA-dependent protein kinase complex DNA-PK phosphorylates and activates NR4A3 and prevents NR4A3 ubiquitination and degradation. Interacts with BRAT1. Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA. Interacts with KAT5. P97313; P00533: EGFR; Xeno; NbExp=4; IntAct=EBI-2272005, EBI-297353; Nucleus Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Comment=A number of isoforms are produced.; Name=1; IsoId=P97313-1; Sequence=Displayed; Name=2; IsoId=P97313-2; Sequence=VSP_017361, VSP_017362; Autophosphorylated at two clusters, the T2609 cluster and the S2056 cluster (PubMed:24158435, PubMed:32103174). Autophosphorylated on Ser-2053, Thr-2605, Thr-2634 and Thr-2643. Ser-2053 and Thr-2605 are DNA damage-inducible phosphorylation sites (inducible with ionizing radiation, IR) dephosphorylated by PPP5C (PubMed:24158435, PubMed:32103174). Autophosphorylation induces a conformational change that leads to remodeling of the DNA-PK complex, requisite for efficient end processing and DNA repair (By similarity). Autophosphorylation in trans within DNA-PK complexes loaded on DNA ends leads to the dissociation of PRKDC from DNA and the transition into the short-range NHEJ complex (By similarity). Autophosphorylation of the T2609 cluster is required for hematopoietic development and protein synthesis in erythrocytes precursors (PubMed:32103174). S-nitrosylated by GAPDH. Polyubiquitinated by RNF144A, leading to proteasomal degradation. Note=Defects in Prkdc are the cause of severe combined immune deficiency (SCID) which is characterized by a lack of mature functional lymphocytes and a high susceptibility to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency syndrome in human infants. Viable. Normal number of erythrocytes and platelets. Normal translation levels in erythrocyte precursors. Belongs to the PI3/PI4-kinase family. nucleotide binding telomere maintenance somitogenesis negative regulation of protein phosphorylation activation of innate immune response B cell lineage commitment pro-B cell differentiation T cell lineage commitment immune system process immunoglobulin production negative regulation of immunoglobulin production positive regulation of immune system process DNA binding double-stranded DNA binding protein kinase activity protein serine/threonine kinase activity DNA-dependent protein kinase activity protein binding ATP binding nucleus nucleoplasm transcription factor complex nucleolus DNA-dependent protein kinase-DNA ligase 4 complex DNA repair double-strand break repair double-strand break repair via nonhomologous end joining protein phosphorylation cellular response to DNA damage stimulus brain development heart development transcription factor binding intrinsic apoptotic signaling pathway in response to DNA damage response to ionizing radiation response to gamma radiation response to activity telomere capping kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation enzyme binding protein domain specific binding lymphocyte differentiation protein destabilization cellular response to insulin stimulus macromolecular complex protein-DNA complex T cell differentiation in thymus V(D)J recombination immunoglobulin V(D)J recombination T cell receptor V(D)J recombination ectopic germ cell programmed cell death regulation of circadian rhythm positive regulation of apoptotic process negative regulation of apoptotic process innate immune response positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation rhythmic process spleen development thymus development positive regulation of developmental growth regulation of smooth muscle cell proliferation regulation of epithelial cell proliferation nonhomologous end joining complex signal transduction involved in mitotic G1 DNA damage checkpoint negative regulation of cellular senescence positive regulation of double-strand break repair via nonhomologous end joining negative regulation of response to gamma radiation uc007yht.1 uc007yht.2 uc007yht.3 
ENSMUST00000023353.4 Mcm4 ENSMUST00000023353.4 minichromosome maintenance complex component 4 (from RefSeq NM_008565.3) ENSMUST00000023353.1 ENSMUST00000023353.2 ENSMUST00000023353.3 Mcm4 NM_008565 Q542F4 Q542F4_MOUSE uc007yhr.1 uc007yhr.2 uc007yhr.3 Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Component of the MCM2-7 complex. Chromosome Nucleus Belongs to the MCM family. nucleotide binding DNA binding DNA helicase activity helicase activity ATP binding nucleus nucleoplasm DNA replication DNA replication initiation hydrolase activity DNA duplex unwinding MCM complex uc007yhr.1 uc007yhr.2 uc007yhr.3 
ENSMUST00000023356.8 Snai2 ENSMUST00000023356.8 snail family zinc finger 2 (from RefSeq NM_011415.3) ENSMUST00000023356.1 ENSMUST00000023356.2 ENSMUST00000023356.3 ENSMUST00000023356.4 ENSMUST00000023356.5 ENSMUST00000023356.6 ENSMUST00000023356.7 NM_011415 Q3UZ96 Q3UZ96_MOUSE Snai2 uc007yhm.1 uc007yhm.2 uc007yhm.3 uc007yhm.4 Nucleus negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding osteoblast differentiation epithelial to mesenchymal transition nucleic acid binding nucleus Notch signaling pathway sensory perception of sound negative regulation of keratinocyte proliferation negative regulation of vitamin D biosynthetic process neural crest cell development positive regulation of cell migration negative regulation of chondrocyte differentiation regulation of chemokine production desmosome disassembly pigmentation negative regulation of DNA damage response, signal transduction by p53 class mediator sequence-specific DNA binding regulation of osteoblast differentiation negative regulation of vitamin D receptor signaling pathway E-box binding cellular response to epidermal growth factor stimulus negative regulation of canonical Wnt signaling pathway negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of bicellular tight junction assembly negative regulation of anoikis uc007yhm.1 uc007yhm.2 uc007yhm.3 uc007yhm.4 
ENSMUST00000023357.14 Cep20 ENSMUST00000023357.14 centrosomal protein 20 (from RefSeq NM_025345.2) CEP20_MOUSE Cep20 ENSMUST00000023357.1 ENSMUST00000023357.10 ENSMUST00000023357.11 ENSMUST00000023357.12 ENSMUST00000023357.13 ENSMUST00000023357.2 ENSMUST00000023357.3 ENSMUST00000023357.4 ENSMUST00000023357.5 ENSMUST00000023357.6 ENSMUST00000023357.7 ENSMUST00000023357.8 ENSMUST00000023357.9 Fopnl For20 NM_025345 Q3UIK2 Q9CZS3 uc007yhh.1 uc007yhh.2 uc007yhh.3 Involved in the biogenesis of cilia (By similarity). Required for the recruitment of PLK1 to centrosomes and S phase progression (By similarity). Homooligomer; probably required for localization to centrosomes (By similarity). Forms a complex with KIAA0753/OFIP and OFD1; within this complex may stabilize the interaction between OFD1 and KIAA0753/OFIP (PubMed:26643951). Interacts with PCM1; this interaction may be mediated by KIAA0753/OFIP (PubMed:26643951). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasmic granule Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Note=Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP. Belongs to the CEP43 family. molecular_function nucleus cytoplasm centrosome centriole microtubule organizing center cytoskeleton cilium cell projection organization motile cilium centriolar satellite microtubule anchoring ciliary basal body cell projection cilium assembly uc007yhh.1 uc007yhh.2 uc007yhh.3 
ENSMUST00000023359.13 Nde1 ENSMUST00000023359.13 nudE neurodevelopment protein 1, transcript variant a (from RefSeq NM_023317.2) ENSMUST00000023359.1 ENSMUST00000023359.10 ENSMUST00000023359.11 ENSMUST00000023359.12 ENSMUST00000023359.2 ENSMUST00000023359.3 ENSMUST00000023359.4 ENSMUST00000023359.5 ENSMUST00000023359.6 ENSMUST00000023359.7 ENSMUST00000023359.8 ENSMUST00000023359.9 NDE1_MOUSE NM_023317 Nude Q3UBS6 Q3UIC1 Q9CZA6 Q9ERR0 uc007ygy.1 uc007ygy.2 uc007ygy.3 uc007ygy.4 Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Interacts with dynactin and PCM1 (By similarity). Self- associates. Interacts with CENPF, LIS1, CNTRL, dynein, tubulin gamma, PAFAH1B1, PCNT, SLMAP and TCP1. Interacts with ZNF365 (By similarity). Q9CZA6; Q155P7: Cenpf; NbExp=8; IntAct=EBI-309934, EBI-2211248; Q9CZA6; Q9NRI5: DISC1; Xeno; NbExp=2; IntAct=EBI-309934, EBI-529989; Q9CZA6; O14576: DYNC1I1; Xeno; NbExp=2; IntAct=EBI-309934, EBI-366267; Q9CZA6; P43034: PAFAH1B1; Xeno; NbExp=6; IntAct=EBI-309934, EBI-720620; Q9CZA6-1; P11531: Dmd; NbExp=2; IntAct=EBI-15949673, EBI-295928; Q9CZA6-1; E9Q6R7: Utrn; NbExp=4; IntAct=EBI-15949673, EBI-15949679; Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cleavage furrow. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9CZA6-1; Sequence=Displayed; Name=2; IsoId=Q9CZA6-2; Sequence=VSP_019307, VSP_019309; Name=3; IsoId=Q9CZA6-3; Sequence=VSP_019308, VSP_019309; Name=4; IsoId=Q9CZA6-4; Sequence=VSP_019306; Highly expressed in ovary. Also expressed in brain, heart, kidney, large intestine, liver, lung, small intestine and testis. Widely expressed in the developing brain, particularly in the neural progenitor cells of ventricular zone and the intermediate zone of the cerebral cortex. Expression peaks at 11 dpc and declines at 15 dpc and 17 dpc. After completion of neuronal migration expression is reduced in the cortex. Phosphorylated in mitosis (By similarity). Phosphorylation at Thr- 246 is essential for the G2/M transition. Homozygous loss of this protein results in microcephaly that preferentially affects the cerebral cortex. Affected animals have a smaller cortex with reduced superficial cortical layers, although cortical lamination is mostly preserved. The smaller cortex size seems to reflect both reduced progenitor cell division and altered specification of cell fates following progenitor cell division. Belongs to the nudE family. establishment of mitotic spindle orientation chromosome, centromeric region kinetochore condensed chromosome kinetochore neuron migration protein binding chromosome cytoplasm centrosome microtubule organizing center spindle cytoskeleton kinesin complex microtubule microtubule nucleation cell cycle chromosome segregation mitotic centrosome separation multicellular organism development nervous system development neuroblast proliferation microtubule binding cell migration protein domain specific binding cerebral cortex development cell differentiation forebrain development microtubule organizing center organization spindle pole centrosome cleavage furrow identical protein binding synapse vesicle transport along microtubule centrosome duplication cell division establishment of chromosome localization centrosome localization regulation of microtubule motor activity uc007ygy.1 uc007ygy.2 uc007ygy.3 uc007ygy.4 
ENSMUST00000023360.14 Mpv17l ENSMUST00000023360.14 Mpv17 transgene, kidney disease mutant-like, transcript variant 1 (from RefSeq NM_033564.3) ENSMUST00000023360.1 ENSMUST00000023360.10 ENSMUST00000023360.11 ENSMUST00000023360.12 ENSMUST00000023360.13 ENSMUST00000023360.2 ENSMUST00000023360.3 ENSMUST00000023360.4 ENSMUST00000023360.5 ENSMUST00000023360.6 ENSMUST00000023360.7 ENSMUST00000023360.8 ENSMUST00000023360.9 MP17L_MOUSE NM_033564 Q3UWD2 Q8CI14 Q99MS3 uc007ygr.1 uc007ygr.2 uc007ygr.3 uc007ygr.4 [Isoform 1]: Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes (PubMed:12471025, PubMed:15541722). Protective against the mitochondrial apoptotic cascade (By similarity). [Isoform 3]: Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes. Q99MS3; Q9JIY5: Htra2; NbExp=2; IntAct=EBI-15727135, EBI-2365838; Q99MS3-1; Q9JIY5: Htra2; NbExp=3; IntAct=EBI-15727082, EBI-2365838; Q99MS3-3; Q9JIY5: Htra2; NbExp=2; IntAct=EBI-15727109, EBI-2365838; [Isoform 1]: Peroxisome membrane ; Multi-pass membrane protein. [Isoform 3]: Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=M-LP long, M-LPL ; IsoId=Q99MS3-1; Sequence=Displayed; Name=2; IsoId=Q99MS3-2; Sequence=VSP_033464, VSP_033466; Name=3; Synonyms=M-LP short, M-LPS ; IsoId=Q99MS3-3; Sequence=VSP_033465; Isoform 1 and isoform 3 are expressed in the kidney (at protein level). Isoform 1 is expressed in the kidney, spleen, heart, brain, lung and liver. Isoform 3 is expressed in the kidney. Isoform 1 and isoform 3 expression increase during development, reache their highest level in adulthood and decrease with aging. [Isoform 3]: Levels increase steadily between 1 week and 6 months after birth and decrease slightly between 6 months and 15 months after birth. [Isoform 3]: By heat shock. Belongs to the peroxisomal membrane protein PXMP2/4 family. protein binding cytoplasm mitochondrion peroxisome peroxisomal membrane negative regulation of hydrogen peroxide biosynthetic process membrane integral component of membrane intracellular membrane-bounded organelle reactive oxygen species metabolic process negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway uc007ygr.1 uc007ygr.2 uc007ygr.3 uc007ygr.4 
ENSMUST00000023362.15 Ntan1 ENSMUST00000023362.15 N-terminal Asn amidase, transcript variant 1 (from RefSeq NM_010946.4) ENSMUST00000023362.1 ENSMUST00000023362.10 ENSMUST00000023362.11 ENSMUST00000023362.12 ENSMUST00000023362.13 ENSMUST00000023362.14 ENSMUST00000023362.2 ENSMUST00000023362.3 ENSMUST00000023362.4 ENSMUST00000023362.5 ENSMUST00000023362.6 ENSMUST00000023362.7 ENSMUST00000023362.8 ENSMUST00000023362.9 NM_010946 NTAN1_MOUSE Ntan1 Q64311 uc007ygk.1 uc007ygk.2 uc007ygk.3 uc007ygk.4 uc007ygk.5 The protein encoded by this gene functions in a step-wise protein degradation process through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asparagine residues on proteins to produce N-terminal L-Aspartate. L-Aspartate substrates are subsequently conjugated to L-Arginine, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Mice with a knock-out of this gene are viable, fertile, and outwardly normal, but show impairments in spontaneous activity and spatial memory, relative to their wild-type counterparts. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position. Reaction=H(+) + H2O + N-terminal L-asparaginyl-[protein] = N-terminal L-aspartyl-[protein] + NH4(+); Xref=Rhea:RHEA:50676, Rhea:RHEA- COMP:12669, Rhea:RHEA-COMP:12776, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:50348, ChEBI:CHEBI:64720; EC=3.5.1.121; Evidence=; Monomer. Cytoplasm nucleus cytoplasm ubiquitin-dependent protein catabolic process memory adult locomotory behavior protein-N-terminal asparagine amidohydrolase activity hydrolase activity uc007ygk.1 uc007ygk.2 uc007ygk.3 uc007ygk.4 uc007ygk.5 
ENSMUST00000023363.8 Rrn3 ENSMUST00000023363.8 RRN3 RNA polymerase I transcription factor homolog (yeast) (from RefSeq NM_001039521.1) B2RS91 ENSMUST00000023363.1 ENSMUST00000023363.2 ENSMUST00000023363.3 ENSMUST00000023363.4 ENSMUST00000023363.5 ENSMUST00000023363.6 ENSMUST00000023363.7 NM_001039521 Q7TNE7 Q8K052 RRN3_MOUSE uc007ygj.1 uc007ygj.2 uc007ygj.3 Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction. Interacts with TAF1B. Interacts with POLR1F, EIF3L and TAF1C (By similarity). Nucleus, nucleolus Phosphorylated at Thr-198 by MAPK9/JNK2, which abrogates initiation complex formation. Belongs to the RRN3 family. RNA polymerase I core binding RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity, core RNA polymerase I binding RNA polymerase I transcriptional preinitiation complex assembly in utero embryonic development nucleus nucleolus DNA-templated transcription, initiation transcription initiation from RNA polymerase I promoter nucleolus organization cytoplasm organization cell proliferation positive regulation of neuron projection development ribosome biogenesis positive regulation of transcription, DNA-templated homeostasis of number of cells RNA polymerase binding negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of DNA-templated transcription, initiation uc007ygj.1 uc007ygj.2 uc007ygj.3 
ENSMUST00000023364.7 Pla2g10 ENSMUST00000023364.7 phospholipase A2, group X, transcript variant 1 (from RefSeq NM_011987.4) ENSMUST00000023364.1 ENSMUST00000023364.2 ENSMUST00000023364.3 ENSMUST00000023364.4 ENSMUST00000023364.5 ENSMUST00000023364.6 NM_011987 PA2GX_MOUSE Q9EQK6 Q9QXX3 uc007ygh.1 uc007ygh.2 uc007ygh.3 uc007ygh.4 uc007ygh.5 This gene encodes a member of the phospholipase A2 family of lipolytic enzymes that hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. The encoded protein undergoes proteolytic processing to generate a calcium-dependent enzyme that plays pivotal roles in the liberation of arachidonic acid from membrane phospholipids leading to the production of various inflammatory lipid mediators, such as prostaglandins. In response to myocardial ischemia/reperfusion, mice lacking the encoded protein display a reduction in myocardial infarct size partly through the suppression of neutorphil cytotoxic activities. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2015]. Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls (PubMed:12359733, PubMed:10531313). Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles (By similarity). Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (By similarity). Efficiently hydrolyzes and inactivates PAF, a potent lipid mediator present in oxidized LDL (By similarity). May act in an autocrine and paracrine manner. Secreted by lung epithelium, targets membrane phospholipids of infiltrating eosinophils, releasing arachidonate and boosting eicosanoid and cysteinyl leukotriene synthesis involved in airway inflammatory response (PubMed:29093264, PubMed:17403936). Secreted by gut epithelium, hydrolyzes dietary and biliary phosphatidylcholines in the gastrointestinal lumen, thereby regulating adipogenesis and body weight (PubMed:21266581). Plays a stem cell regulator role in colon epithelium. Within intracellular compartment, mediates Paneth-like cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ISC). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates the Wnt signaling pathway in ISCs and tissue regeneration (PubMed:27292189). May participate in hair follicle morphogenesis by regulating phosphatidylethanolamines metabolism at the outermost epithelial layer and facilitating melanin synthesis (PubMed:21266583). By generating lysophosphatidylcholines (LPCs) at sperm acrosome controls sperm cell capacitation, acrosome reaction and overall fertility (PubMed:20424324, PubMed:21266581). May promote neurite outgrowth in neuron fibers involved in nociception (PubMed:21266581). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (PubMed:12359733). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). In pulmonary epithelium, may contribute to host defense response against adenoviral infection. Prevents adenovirus entry into host cells by hydrolyzing host cell plasma membrane, releasing C16:0 LPCs that inhibit virus- mediated membrane fusion and viral infection. Likely prevents adenoviral entry into the endosomes of host cells (By similarity). May play a role in maturation and activation of innate immune cells including macrophages, group 2 innate lymphoid cells and mast cells (PubMed:29093264). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- octadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40519, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73858, ChEBI:CHEBI:74965; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40520; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoglycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn- glycero-3-phosphoglycerol + H(+); Xref=Rhea:RHEA:44524, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:84472, ChEBI:CHEBI:84475; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44525; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate; Xref=Rhea:RHEA:45472, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72829, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45473; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L- serine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phospho-L-serine + H(+); Xref=Rhea:RHEA:41752, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75020, ChEBI:CHEBI:75029; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41753; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+); Xref=Rhea:RHEA:63996, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57518, ChEBI:CHEBI:64839; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63997; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1- O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:40479, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:44811, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40480; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Interacts with PLA2R1; this interaction mediates PLA2G10 clearance and inactivation. Secreted sosome Cytoplasmic vesicle, secretory vesicle, acrosome Expressed at high levels in testis and the gastrointestinal tract including stomach and colon. Expressed at lower levels in other tissues including small intestine, uterus, oviduct, lung, thymus, spleen and brain (PubMed:11019817, PubMed:21266581). Expressed in Paneth-like secretory epithelial cells of the colon (PubMed:27292189). Expressed in gastric and ileac epithelial cells and in glandular epithelium of intestinal mucosa (at protein level) (PubMed:21266581). Expressed in late spermatogenic cells, spermatocytes and spermatids, but not spermatogonia in seminiferous tubules (at protein level) (PubMed:20424324). Expressed mainly in the apical side of endometrial epithelial cells and in the interstitium beneath the epithelium of uterus (at protein level) (PubMed:21266581). Expressed in resident spleen macrophages (at protein level) (PubMed:11019817). Expressed at outermost layer of hair follicles (PubMed:21266583). Expressed in dorsal root ganglia in both NEFH-positive A-fibers and PRPH-positive C-fibers (at protein level) (PubMed:21266581). During hair follicle growth cycle, it is detected at low levels at 17.5 dpc (hair folliculogenesis stage), increases to a maximum expression level by P10 (anagen), declines to the basal level at P15-20 (catagen to telogen), and again increases at P25 (re-entry into the next anagen). Up-regulated in alveolar macrophages upon allergen-induced airway inflammation (PubMed:17403936). Up-regulated in bronchoalveolar lavage fluid (BALF) in response to house dust mite proteolytic allergens (PubMed:29093264). Mutant male mice have reduced fertility due to deficient acrosome reaction (PubMed:20424324). Mutant mice are lean and protected from age-related adiposity and fatty liver (PubMed:21266581). Mutant mice show resistance to allergen-induced asthma, with marked reduction of inflammatory cell recruitment in the lungs, reduced goblet cell metaplasia, smooth muscle cell layer thickening and subepithelial fibrosis and impaired mucus hypersecretion. This resistance to allergen-induced inflammation is associated with deficient T helper type 2 immune response and decreased eicosanoid synthesis (PubMed:17403936). Mutant mice are protected against airway allergic inflammation induced by house dust mite allergens (PubMed:29093264). Mutant mice show hair shaft abnormalities including hypoplastic outer root sheath and reduced number of melanin granules (PubMed:21266583). Belongs to the phospholipase A2 family. phospholipase activity phospholipase A2 activity calcium ion binding extracellular region extracellular space lipid metabolic process phospholipid metabolic process axon guidance positive regulation of lipid storage lipid catabolic process hydrolase activity positive regulation of cellular protein metabolic process positive regulation of prostaglandin secretion cholesterol homeostasis regulation of macrophage activation negative regulation of sequence-specific DNA binding transcription factor activity metal ion binding arachidonic acid secretion lysophospholipid transport positive regulation of arachidonic acid secretion negative regulation of cholesterol efflux cellular response to leukemia inhibitory factor uc007ygh.1 uc007ygh.2 uc007ygh.3 uc007ygh.4 uc007ygh.5 
ENSMUST00000023365.13 Bfar ENSMUST00000023365.13 bifunctional apoptosis regulator, transcript variant 1 (from RefSeq NM_025976.5) A0A0R4J040 A0A0R4J040_MOUSE Bfar ENSMUST00000023365.1 ENSMUST00000023365.10 ENSMUST00000023365.11 ENSMUST00000023365.12 ENSMUST00000023365.2 ENSMUST00000023365.3 ENSMUST00000023365.4 ENSMUST00000023365.5 ENSMUST00000023365.6 ENSMUST00000023365.7 ENSMUST00000023365.8 ENSMUST00000023365.9 NM_025976 uc007ygf.1 uc007ygf.2 uc007ygf.3 protein polyubiquitination endoplasmic reticulum ubiquitin-dependent protein catabolic process membrane integral component of membrane protein binding, bridging negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process protein autoubiquitination ubiquitin protein ligase activity protein K63-linked ubiquitination protein K48-linked ubiquitination caspase binding negative regulation of IRE1-mediated unfolded protein response uc007ygf.1 uc007ygf.2 uc007ygf.3 
ENSMUST00000023390.5 Drd3 ENSMUST00000023390.5 dopamine receptor D3 (from RefSeq NM_007877.2) Drd3 ENSMUST00000023390.1 ENSMUST00000023390.2 ENSMUST00000023390.3 ENSMUST00000023390.4 NM_007877 Q0VEC4 Q0VEC4_MOUSE uc007zgi.1 uc007zgi.2 uc007zgi.3 Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. negative regulation of transcription from RNA polymerase II promoter dopamine neurotransmitter receptor activity, coupled via Gi/Go synaptic transmission, dopaminergic G-protein coupled receptor internalization G-protein coupled receptor activity dopamine neurotransmitter receptor activity plasma membrane integral component of plasma membrane cellular calcium ion homeostasis autophagy signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway adenylate cyclase-inhibiting dopamine receptor signaling pathway dopamine receptor signaling pathway drug binding positive regulation of cell proliferation membrane integral component of membrane protein domain specific binding endocytic vesicle D1 dopamine receptor binding negative regulation of sodium:proton antiporter activity positive regulation of cytokinesis response to histamine dopamine binding gastric emptying positive regulation of renal sodium excretion regulation of locomotion response to cocaine response to drug cell projection negative regulation of apoptotic process apical part of cell regulation of circadian sleep/wake cycle, sleep positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter acid secretion behavioral response to cocaine arachidonic acid secretion negative regulation of protein secretion prepulse inhibition regulation of locomotion involved in locomotory behavior glutamatergic synapse GABA-ergic synapse integral component of postsynaptic density membrane uc007zgi.1 uc007zgi.2 uc007zgi.3 
ENSMUST00000023391.16 Mrpl40 ENSMUST00000023391.16 mitochondrial ribosomal protein L40 (from RefSeq NM_010922.2) ENSMUST00000023391.1 ENSMUST00000023391.10 ENSMUST00000023391.11 ENSMUST00000023391.12 ENSMUST00000023391.13 ENSMUST00000023391.14 ENSMUST00000023391.15 ENSMUST00000023391.2 ENSMUST00000023391.3 ENSMUST00000023391.4 ENSMUST00000023391.5 ENSMUST00000023391.6 ENSMUST00000023391.7 ENSMUST00000023391.8 ENSMUST00000023391.9 NM_010922 Nlvcf Q9CS52 Q9Z2Q5 RM40_MOUSE uc007yop.1 uc007yop.2 uc007yop.3 uc007yop.4 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Ubiquitous. Belongs to the mitochondrion-specific ribosomal protein mL40 family. molecular_function mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit ribosome biological_process uc007yop.1 uc007yop.2 uc007yop.3 uc007yop.4 
ENSMUST00000023400.4 Tmem114 ENSMUST00000023400.4 transmembrane protein 114 (from RefSeq NM_029070.2) Cldn26 ENSMUST00000023400.1 ENSMUST00000023400.2 ENSMUST00000023400.3 NM_029070 Q9D563 TM114_MOUSE Tmem114 uc007yck.1 uc007yck.2 uc007yck.3 Cell membrane ; Multi-pass membrane protein Note=N- glycosylation at Asn-54 and Asn-88 is required for plasma membrane localization. Expressed weakly in the eye from as early as 13.5 dpc, with ocular expression up-regulated postnatally. By 10 weeks, expressed strongly in the lens epithelial cells and weakly in lens fibers. In adult, expressed in eye, brain and testis. molecular_function plasma membrane biological_process membrane integral component of membrane apical plasma membrane apicolateral plasma membrane uc007yck.1 uc007yck.2 uc007yck.3 
ENSMUST00000023405.16 Arl6 ENSMUST00000023405.16 ADP-ribosylation factor-like 6, transcript variant 1 (from RefSeq NM_019665.3) ARL6 Arl6 ENSMUST00000023405.1 ENSMUST00000023405.10 ENSMUST00000023405.11 ENSMUST00000023405.12 ENSMUST00000023405.13 ENSMUST00000023405.14 ENSMUST00000023405.15 ENSMUST00000023405.2 ENSMUST00000023405.3 ENSMUST00000023405.4 ENSMUST00000023405.5 ENSMUST00000023405.6 ENSMUST00000023405.7 ENSMUST00000023405.8 ENSMUST00000023405.9 NM_019665 Q3TUM2 Q3TUM2_MOUSE uc007zpl.1 uc007zpl.2 uc007zpl.3 uc007zpl.4 Cell projection, cilium membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTPase activity GTP binding uc007zpl.1 uc007zpl.2 uc007zpl.3 uc007zpl.4 
ENSMUST00000023407.12 Riox2 ENSMUST00000023407.12 ribosomal oxygenase 2 (from RefSeq NM_025910.3) ENSMUST00000023407.1 ENSMUST00000023407.10 ENSMUST00000023407.11 ENSMUST00000023407.2 ENSMUST00000023407.3 ENSMUST00000023407.4 ENSMUST00000023407.5 ENSMUST00000023407.6 ENSMUST00000023407.7 ENSMUST00000023407.8 ENSMUST00000023407.9 Mina Mina53 NM_025910 Q8CD15 Q8QZX1 Q9CQ03 RIOX2_MOUSE Riox2 uc007zph.1 uc007zph.2 uc007zph.3 uc007zph.4 Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. Reaction=2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 = (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate; Xref=Rhea:RHEA:54024, Rhea:RHEA-COMP:13760, Rhea:RHEA-COMP:13761, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29979, ChEBI:CHEBI:30031, ChEBI:CHEBI:138021; Evidence=; Reaction=2-oxoglutarate + L-histidyl-[protein] + O2 = (3S)-3-hydroxy-L- histidyl-[protein] + CO2 + succinate; Xref=Rhea:RHEA:54256, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:13840, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29979, ChEBI:CHEBI:30031, ChEBI:CHEBI:138021; EC=1.14.11.79; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Nucleus Nucleus, nucleolus Predominantly expressed in testis. Expressed at high levels in spleen, thymus, and colon, but barely detectable in brain, skeletal muscle, and seminal vesicle (at protein level). In testis, expressed in the nuclei of spermatogonia at all stages of the seminiferous epithelial cycle, and in meiotic prophase cells such as preleptotene, leptotene and zygotene, and weakly in early pachytene spermatocytes, but is absent in late pachytene spermatocytes, spermatids and mature sperm (at protein level). Up-regulated in experimentally-induced cryptorchid testis. Belongs to the ROX family. MINA53 subfamily. transcription corepressor activity nucleus transcription factor complex nucleolus cytosol cell proliferation oxidoreductase activity histone demethylase activity (H3-K4 specific) histone H3-K4 demethylation regulation of cell proliferation ribosome biogenesis identical protein binding metal ion binding dioxygenase activity histone demethylase activity (H3-K36 specific) oxidation-reduction process histone H3-K36 demethylation negative regulation of nucleic acid-templated transcription uc007zph.1 uc007zph.2 uc007zph.3 uc007zph.4 
ENSMUST00000023426.12 Cldnd1 ENSMUST00000023426.12 claudin domain containing 1, transcript variant 5 (from RefSeq NR_045518.1) CLDN1_MOUSE Cldn25 D11Moh34 ENSMUST00000023426.1 ENSMUST00000023426.10 ENSMUST00000023426.11 ENSMUST00000023426.2 ENSMUST00000023426.3 ENSMUST00000023426.4 ENSMUST00000023426.5 ENSMUST00000023426.6 ENSMUST00000023426.7 ENSMUST00000023426.8 ENSMUST00000023426.9 NR_045518 Q3U7C4 Q9CQX5 uc007zoc.1 uc007zoc.2 uc007zoc.3 uc007zoc.4 Membrane ; Multi-pass membrane protein Belongs to the PMP-22/EMP/MP20 family. molecular_function biological_process membrane integral component of membrane apical plasma membrane uc007zoc.1 uc007zoc.2 uc007zoc.3 uc007zoc.4 
ENSMUST00000023432.10 Nit2 ENSMUST00000023432.10 nitrilase family, member 2 (from RefSeq NM_023175.1) D16Ertd502e ENSMUST00000023432.1 ENSMUST00000023432.2 ENSMUST00000023432.3 ENSMUST00000023432.4 ENSMUST00000023432.5 ENSMUST00000023432.6 ENSMUST00000023432.7 ENSMUST00000023432.8 ENSMUST00000023432.9 NIT2_MOUSE NM_023175 Nit2 Q9CTG9 Q9JHW2 uc007zna.1 uc007zna.2 Has omega-amidase activity (PubMed:19596042, PubMed:28373563). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19596042). Can also hydrolyze gamma-monomethyl-alpha- ketoglutarate in vitro (PubMed:19596042). Reaction=a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH4(+); Xref=Rhea:RHEA:11716, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:28965, ChEBI:CHEBI:77450; EC=3.5.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11717; Evidence=; Reaction=2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+); Xref=Rhea:RHEA:32963, ChEBI:CHEBI:15377, ChEBI:CHEBI:16769, ChEBI:CHEBI:16810, ChEBI:CHEBI:28938; EC=3.5.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32964; Evidence=; Reaction=2-oxosuccinamate + H2O = NH4(+) + oxaloacetate; Xref=Rhea:RHEA:59412, ChEBI:CHEBI:15377, ChEBI:CHEBI:16452, ChEBI:CHEBI:28938, ChEBI:CHEBI:57735; EC=3.5.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59413; Evidence=; Kinetic parameters: KM=0.195 mM for 2-oxoglutaramate (at pH 8.5) ; KM=0.25 mM for 2-oxoglutaramate (at pH 8.5) ; KM=1.48 mM for glutaramate (at pH 7.2) ; KM=1.27 mM for glutaramate (at pH 8.5) ; KM=0.14 mM for succinamate (at pH 8.5) ; KM=0.017 mM for 2-oxosuccinamate (at pH 8.5) ; KM=0.003 mM for 2-oxosuccinamate (at pH 7.2) ; KM=0.012 mM for gamma-monomethyl-alpha-ketoglutarate (at pH 7.2) ; Vmax=32.0 umol/min/mg enzyme with 2-oxoglutaramate as substrate (at pH 8.5) ; Vmax=19.4 umol/min/mg enzyme with 2-oxoglutaramate as substrate (at pH 8.5) ; Vmax=1.6 umol/min/mg enzyme with 2-oxosuccinamate as substrate (at pH 8.5) ; Vmax=16 umol/min/mg enzyme with glutaramate as substrate (at pH 8.5) ; Vmax=5.1 umol/min/mg enzyme with succinamate as substrate (at pH 8.5) ; Vmax=245.2 umol/min/mg enzyme with gamma-monomethyl-alpha- ketoglutarate as substrate (at pH 7.2) ; Vmax=7.5 umol/min/mg enzyme with glutaramate as substrate (at pH 7.2) ; Vmax=3.6 umol/min/mg enzyme with succinamate as substrate (at pH 7.2) ; Vmax=2.1 umol/min/mg enzyme with 2-oxosuccinamate as substrate (at pH 7.2) ; Note=In solution, 2-oxoglutaramate is in equilibrium with a cyclic form (2-hydroxy-5-oxoproline), and at pH 8.0 or above, the rate of ring opening is no longer limiting for the omega-amidase reaction (PubMed:19596042). kcat is 10.7 sec(-1) with 2-oxoglutaramate as substrate (PubMed:28373563). Homodimer. Cytoplasm Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. cytoplasm mitochondrion centrosome cytosol oxaloacetate metabolic process asparagine metabolic process glutamine metabolic process nitrogen compound metabolic process hydrolase activity omega-amidase activity uc007zna.1 uc007zna.2 
ENSMUST00000023435.6 Tmem45a ENSMUST00000023435.6 transmembrane protein 45a (from RefSeq NM_019631.3) ENSMUST00000023435.1 ENSMUST00000023435.2 ENSMUST00000023435.3 ENSMUST00000023435.4 ENSMUST00000023435.5 NM_019631 Q8BFU6 Q8BFU6_MOUSE Tmem45a uc007zmx.1 uc007zmx.2 uc007zmx.3 Membrane ; Multi- pass membrane protein Belongs to the TMEM45 family. membrane integral component of membrane uc007zmx.1 uc007zmx.2 uc007zmx.3 
ENSMUST00000023437.5 Adgrg7 ENSMUST00000023437.5 adhesion G protein-coupled receptor G7 (from RefSeq NM_172825.3) A2RSY9 AGRG7_MOUSE ENSMUST00000023437.1 ENSMUST00000023437.2 ENSMUST00000023437.3 ENSMUST00000023437.4 Gpr128 NM_172825 Q80T42 Q8BM96 uc007zmw.1 uc007zmw.2 uc007zmw.3 Orphan receptor. Membrane ; Multi-pass membrane protein Selectively expressed in the intestinal tissues. Deficient mice exhibit less body weight gain and an increase in intestinal contraction frequency. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. transmembrane signaling receptor activity G-protein coupled receptor activity integral component of plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway membrane integral component of membrane uc007zmw.1 uc007zmw.2 uc007zmw.3 
ENSMUST00000023441.11 P2rx6 ENSMUST00000023441.11 purinergic receptor P2X, ligand-gated ion channel, 6, transcript variant 3 (from RefSeq NR_189665.1) ENSMUST00000023441.1 ENSMUST00000023441.10 ENSMUST00000023441.2 ENSMUST00000023441.3 ENSMUST00000023441.4 ENSMUST00000023441.5 ENSMUST00000023441.6 ENSMUST00000023441.7 ENSMUST00000023441.8 ENSMUST00000023441.9 G3X8W3 NR_189665 O54803 P2RX6_MOUSE P2rxl1 Q3UUD0 uc007yli.1 uc007yli.2 uc007yli.3 uc007yli.4 Receptor for ATP that acts as a ligand-gated ion channel. Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers. Membrane; Multi-pass membrane protein. Predominantly expressed in skeletal muscle. Also expressed in lung. N-glycosylated. Belongs to the P2X receptor family. Sequence=BAA24693.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE23697.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity ion channel activity ATP binding integral component of nuclear inner membrane cytoplasm integral component of plasma membrane ion transport postsynaptic density membrane integral component of membrane cell junction response to ATP purinergic nucleotide receptor signaling pathway identical protein binding neuronal cell body dendritic spine receptor complex protein homooligomerization protein heterooligomerization excitatory postsynaptic potential cation transmembrane transport glutamatergic synapse integral component of postsynaptic specialization membrane uc007yli.1 uc007yli.2 uc007yli.3 uc007yli.4 
ENSMUST00000023444.11 Lztr1 ENSMUST00000023444.11 leucine-zipper-like transcriptional regulator, 1, transcript variant 1 (from RefSeq NM_025808.4) ENSMUST00000023444.1 ENSMUST00000023444.10 ENSMUST00000023444.2 ENSMUST00000023444.3 ENSMUST00000023444.4 ENSMUST00000023444.5 ENSMUST00000023444.6 ENSMUST00000023444.7 ENSMUST00000023444.8 ENSMUST00000023444.9 LZTR1_MOUSE Lztr1 NM_025808 Q9CQ33 Tcfl2 uc007yla.1 uc007yla.2 uc007yla.3 This gene encodes a member of the BR-C, ttk and bab-kelch superfamily that, in humans, localizes to the Golgi network and is associated with the ras / mitogen-activated protein kinase pathway. Loss-of-function mutations in the human ortholog are associated with glioblastoma multiforme, schwannomatosis, Noonan syndrome, and DiGeorge syndrome. [provided by RefSeq, Sep 2016]. Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762). Protein modification; protein ubiquitination. Homodimer. Component of the BCR(LZTR1) E3 ubiquitin ligase complex, at least composed of CUL3, LZTR1 and RBX1. Interacts with Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Interacts with RAF1. Interacts with SHOC2. Interacts with PPP1CB. Endomembrane system Recycling endosome Golgi apparatus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQ33-1; Sequence=Displayed; Name=2; IsoId=Q9CQ33-2; Sequence=VSP_007170; Widely expressed. Phosphorylated on tyrosine upon induction of apoptosis, leading to its degradation by the proteasome. Embryonic lethality between 17.5 dpc and birth (PubMed:30442762). Impaired ubiquitination of Ras (K-Ras/Kras, N- Ras/Nras and H-Ras/Hras) (PubMed:30442762). Heterozygous mice display heart malformations, including decreased left ventricular systolic function, increased diastolic dimensions, eccentric hypertrophy, increased cardiomyocyte area and reduced longevity; phenotypes that are reminiscent of human Noonan Syndrome (PubMed:30442762). [Isoform 2]: May result from the retention of an intron in the cDNA in position 800. Belongs to the LZTR1 family. Sequence=BAC40662.1; Type=Erroneous initiation; Evidence=; endosome Golgi apparatus endomembrane system membrane protein ubiquitination Ras GTPase binding Cul3-RING ubiquitin ligase complex negative regulation of Ras protein signal transduction recycling endosome recycling endosome membrane uc007yla.1 uc007yla.2 uc007yla.3 
ENSMUST00000023449.11 Snap29 ENSMUST00000023449.11 synaptosomal-associated protein 29 (from RefSeq NM_023348.4) ENSMUST00000023449.1 ENSMUST00000023449.10 ENSMUST00000023449.2 ENSMUST00000023449.3 ENSMUST00000023449.4 ENSMUST00000023449.5 ENSMUST00000023449.6 ENSMUST00000023449.7 ENSMUST00000023449.8 ENSMUST00000023449.9 NM_023348 Q3UGN0 Q9DBC5 Q9ERB0 SNP29_MOUSE Snap29 uc007yku.1 uc007yku.2 uc007yku.3 SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. Forms a SNARE complex, composed of VAMP8, SNAP29 and STX17, involved in fusion of autophagosome with lysosome (By similarity). Interacts with multiple syntaxins including STX6 (By similarity). Interacts with EIPR1 (By similarity). Interacts with STX17; this interaction is increased in the absence of TMEM39A (By similarity). Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein Cytoplasmic vesicle, autophagosome membrane ; Peripheral membrane protein Cell projection, cilium membrane ; Peripheral membrane protein Note=Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is cytoplasmic. Localizes to the ciliary pocket from where the cilium protrudes. Belongs to the SNAP-25 family. Golgi membrane autophagosome membrane SNAP receptor activity nucleoplasm cytoplasm autophagosome Golgi apparatus centrosome cytosol plasma membrane cilium exocytosis vesicle fusion autophagy protein transport membrane synaptic vesicle priming autophagosome docking syntaxin binding ciliary pocket membrane cell projection organization SNARE complex cytoplasmic vesicle synaptic vesicle fusion to presynaptic active zone membrane cell projection ciliary membrane cilium assembly autophagosome maturation presynapse uc007yku.1 uc007yku.2 uc007yku.3 
ENSMUST00000023450.15 Serpind1 ENSMUST00000023450.15 serine (or cysteine) peptidase inhibitor, clade D, member 1, transcript variant 1 (from RefSeq NM_008223.4) ENSMUST00000023450.1 ENSMUST00000023450.10 ENSMUST00000023450.11 ENSMUST00000023450.12 ENSMUST00000023450.13 ENSMUST00000023450.14 ENSMUST00000023450.2 ENSMUST00000023450.3 ENSMUST00000023450.4 ENSMUST00000023450.5 ENSMUST00000023450.6 ENSMUST00000023450.7 ENSMUST00000023450.8 ENSMUST00000023450.9 HEP2_MOUSE Hcf2 Hcii NM_008223 P49182 uc007yks.1 uc007yks.2 uc007yks.3 uc007yks.4 Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT). Also inhibits chymotrypsin, but in a glycosaminoglycan- independent manner. Expressed predominantly in liver. The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition. N-glycosylated; different glycan composition appears to lead to two forms of this protein (68 and 72 kDa). Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular space blood coagulation hemostasis heparin binding negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc007yks.1 uc007yks.2 uc007yks.3 uc007yks.4 
ENSMUST00000023452.16 Ccdc116 ENSMUST00000023452.16 coiled-coil domain containing 116, transcript variant 3 (from RefSeq NM_001306169.1) CC116_MOUSE ENSMUST00000023452.1 ENSMUST00000023452.10 ENSMUST00000023452.11 ENSMUST00000023452.12 ENSMUST00000023452.13 ENSMUST00000023452.14 ENSMUST00000023452.15 ENSMUST00000023452.2 ENSMUST00000023452.3 ENSMUST00000023452.4 ENSMUST00000023452.5 ENSMUST00000023452.6 ENSMUST00000023452.7 ENSMUST00000023452.8 ENSMUST00000023452.9 NM_001306169 Q6PFY7 Q80X53 Q9D5J4 uc057bhm.1 uc057bhm.2 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton biological_process uc057bhm.1 uc057bhm.2 
ENSMUST00000023453.10 Sdf2l1 ENSMUST00000023453.10 stromal cell-derived factor 2-like 1 (from RefSeq NM_022324.3) ENSMUST00000023453.1 ENSMUST00000023453.2 ENSMUST00000023453.3 ENSMUST00000023453.4 ENSMUST00000023453.5 ENSMUST00000023453.6 ENSMUST00000023453.7 ENSMUST00000023453.8 ENSMUST00000023453.9 NM_022324 Q9ESP1 Q9ESP2 SDF2L_MOUSE uc007ykc.1 uc007ykc.2 uc007ykc.3 Endoplasmic reticulum lumen Ubiquitously expressed with high expression in the testis, ovary, uterus, and low expression in heart and skeletal muscle. By tunicamycin and a calcium ionophore, A23187. dolichyl-phosphate-mannose-protein mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane membrane endoplasmic reticulum chaperone complex response to endoplasmic reticulum stress protein O-linked mannosylation regulation of apoptotic process chaperone binding ATPase binding misfolded protein binding cellular response to misfolded protein ER-associated misfolded protein catabolic process uc007ykc.1 uc007ykc.2 uc007ykc.3 
ENSMUST00000023455.14 Ppil2 ENSMUST00000023455.14 peptidylprolyl isomerase (cyclophilin)-like 2, transcript variant 2 (from RefSeq NM_144954.3) ENSMUST00000023455.1 ENSMUST00000023455.10 ENSMUST00000023455.11 ENSMUST00000023455.12 ENSMUST00000023455.13 ENSMUST00000023455.2 ENSMUST00000023455.3 ENSMUST00000023455.4 ENSMUST00000023455.5 ENSMUST00000023455.6 ENSMUST00000023455.7 ENSMUST00000023455.8 ENSMUST00000023455.9 NM_144954 PPIL2_MOUSE Ppil2 Q542A2 Q9CZL1 Q9D787 uc007yjy.1 uc007yjy.2 uc007yjy.3 uc007yjy.4 uc007yjy.5 Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'- linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with PRPF8/PRP8, EFTUD2/SNU114 and PLRG1 (By similarity). Interacts with isoform 2 of BSG (By similarity). Interacts (via the PPIase cyclophilin-type domain) with CRNKL1; they may form a trimeric complex with HSP90. Nucleus Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily. Despite the fact that it belongs to the cyclophilin-type PPIase family, it has probably no peptidyl-prolyl cis-trans isomerase activity due to the presence of a tyrosine instead of a tryptophan at position 389. protein polyubiquitination protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity ubiquitin-protein transferase activity nucleus nucleoplasm cytoplasm plasma membrane protein folding protein ubiquitination transferase activity ubiquitin-ubiquitin ligase activity ubiquitin protein ligase activity protein localization to plasma membrane uc007yjy.1 uc007yjy.2 uc007yjy.3 uc007yjy.4 uc007yjy.5 
ENSMUST00000023460.7 Ncbp2 ENSMUST00000023460.7 nuclear cap binding protein subunit 2 (from RefSeq NM_026554.4) Cbp20 ENSMUST00000023460.1 ENSMUST00000023460.2 ENSMUST00000023460.3 ENSMUST00000023460.4 ENSMUST00000023460.5 ENSMUST00000023460.6 NCBP2_MOUSE NM_026554 Q0VF93 Q3UI86 Q9CQ49 uc007yxz.1 uc007yxz.2 uc007yxz.3 uc007yxz.4 Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon- junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By similarity). Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20 that interacts with m7GpppG-capped RNA (By similarity). Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA (PubMed:10786834). Interacts with PHAX/RNUXA, EIF4G1, HNRNPF, HNRNPH1 and ALYREF/THOC4/ALY (By similarity). Interacts with SRRT/ARS2 and KPNA3 (By similarity). Nucleus Cytoplasm Belongs to the RRM NCBP2 family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay RNA cap binding RNA 7-methylguanosine cap binding mRNA splicing, via spliceosome nucleic acid binding mRNA binding nucleus nucleoplasm cytoplasm mRNA cap binding complex nuclear cap binding complex mRNA processing snRNA export from nucleus regulation of translation regulation of translational initiation RNA splicing snRNA binding gene silencing by RNA positive regulation of mRNA 3'-end processing RNA cap binding complex mRNA cis splicing, via spliceosome positive regulation of RNA export from nucleus mRNA transport pre-mRNA cleavage required for polyadenylation RNA binding uc007yxz.1 uc007yxz.2 uc007yxz.3 uc007yxz.4 
ENSMUST00000023464.6 Meltf ENSMUST00000023464.6 melanotransferrin (from RefSeq NM_013900.2) ENSMUST00000023464.1 ENSMUST00000023464.2 ENSMUST00000023464.3 ENSMUST00000023464.4 ENSMUST00000023464.5 Mfi2 Mtf NM_013900 Q9R0R1 TRFM_MOUSE uc007yxv.1 uc007yxv.2 uc007yxv.3 Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. Cell membrane ; Lipid-anchor, GPI- anchor Belongs to the transferrin family. iron ion binding extracellular region extracellular space plasma membrane ion transport iron ion transport cell surface positive regulation of plasminogen activation membrane anchored component of membrane anchored component of plasma membrane metal ion binding iron ion homeostasis positive regulation of extracellular matrix disassembly negative regulation of substrate adhesion-dependent cell spreading cellular iron ion homeostasis uc007yxv.1 uc007yxv.2 uc007yxv.3 
ENSMUST00000023467.9 Pak2 ENSMUST00000023467.9 p21 (RAC1) activated kinase 2 (from RefSeq NM_177326.3) ENSMUST00000023467.1 ENSMUST00000023467.2 ENSMUST00000023467.3 ENSMUST00000023467.4 ENSMUST00000023467.5 ENSMUST00000023467.6 ENSMUST00000023467.7 ENSMUST00000023467.8 NM_177326 PAK2_MOUSE Q8CIN4 uc007yyd.1 uc007yyd.2 uc007yyd.3 Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:11278362). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (By similarity). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (By similarity). Full-length PAK2 stimulates cell survival and cell growth (By similarity). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (By similarity). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (By similarity). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:11278362). Phosphorylates CASP7, thereby preventing its activity (By similarity). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (By similarity). On the other hand, apoptotic stimuli such as DNA damage lead to caspase- mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (By similarity). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-402 and allows the kinase domain to adopt an active structure. Following caspase cleavage, autophosphorylated PAK-2p34 is constitutively active (By similarity). Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with SH3MD4. Interacts with SCRIB. Interacts with ARHGEF7 and GIT1. PAK-2p34 interacts with ARHGAP10. Interacts with RAC1 (By similarity). Q8CIN4; P42859: Htt; NbExp=2; IntAct=EBI-1559317, EBI-5327353; [Serine/threonine-protein kinase PAK 2]: Cytoplasm Nucleus Note=MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane. [PAK-2p34]: Nucleus Cytoplasm, perinuclear region Membrane ; Lipid-anchor Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane. Full-length PAK2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK-2p34, become highly autophosphorylated. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate (By similarity). During apoptosis proteolytically cleaved by caspase-3 or caspase- 3-like proteases to yield active PAK-2p34. Ubiquitinated, leading to its proteasomal degradation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. nucleotide binding catalytic activity protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm cytosol protein phosphorylation apoptotic process metabolic process postsynaptic density membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation protein kinase binding signal transduction by protein phosphorylation protein tyrosine kinase activator activity small GTPase binding activation of protein kinase activity regulation of growth identical protein binding regulation of apoptotic process negative regulation of apoptotic process protein autophosphorylation Rac GTPase binding perinuclear region of cytoplasm positive regulation of peptidyl-tyrosine phosphorylation dendritic spine development positive regulation of protein tyrosine kinase activity cellular response to organic cyclic compound glutamatergic synapse positive regulation of extrinsic apoptotic signaling pathway negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis uc007yyd.1 uc007yyd.2 uc007yyd.3 
ENSMUST00000023468.6 Spag6l ENSMUST00000023468.6 sperm associated antigen 6-like, transcript variant 1 (from RefSeq NM_015773.3) ENSMUST00000023468.1 ENSMUST00000023468.2 ENSMUST00000023468.3 ENSMUST00000023468.4 ENSMUST00000023468.5 NM_015773 Pf16 Q8K461 Q9JLI7 SPAG6_MOUSE Spag6 uc007yjb.1 uc007yjb.2 uc007yjb.3 uc007yjb.4 Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. Interacts with SPAG16 and SPAG17. Q9JLI7; Q5S003: Spag17; NbExp=3; IntAct=EBI-1783654, EBI-1783665; Cytoplasm, cytoskeleton Cell projection, cilium, flagellum Cytoplasm, cytoskeleton, cilium axoneme Note=Associated with microtubules. Detected on the sperm flagellum (PubMed:10684790). Localizes in the cilium axoneme in a SPEF1-dependent manner (PubMed:30535028). Highly expressed in testis. Not detected in prostate, ovary, spleen, thymus, small intestine, colon and peripheral blood leukocytes. Note=Defects in Spag6 are a cause of hydrocephalus and of male infertility. In null embryos the central apparatus is unstable leading to a loss, and presumably degradation of proteins to which SPAG6 normally binds, including SPAG16 and SPAG17. protein binding cytoplasm cytoskeleton microtubule cilium sperm axoneme assembly microtubule cytoskeleton ventricular system development cell projection organization flagellated sperm motility motile cilium cell projection sperm principal piece axonemal central apparatus uc007yjb.1 uc007yjb.2 uc007yjb.3 uc007yjb.4 
ENSMUST00000023478.8 Igsf11 ENSMUST00000023478.8 immunoglobulin superfamily, member 11 (from RefSeq NM_170599.2) ENSMUST00000023478.1 ENSMUST00000023478.2 ENSMUST00000023478.3 ENSMUST00000023478.4 ENSMUST00000023478.5 ENSMUST00000023478.6 ENSMUST00000023478.7 IGS11_MOUSE NM_170599 P0C673 uc007zfp.1 uc007zfp.2 uc007zfp.3 uc007zfp.4 Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (By similarity). Cell membrane; Single-pass type I membrane protein. Highly expressed in testis and detected in kidney and adrenal gland. In brain, expressed in commissure fibers of the corpus callosum and pyramidal cell layers of the dentate gyrus and hippocampus where it is probably expressed by both neurons and glial cells. N-glycosylated. plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules postsynaptic density membrane integral component of membrane ionotropic glutamate receptor binding regulation of growth maintenance of protein location regulation of synaptic plasticity excitatory synapse positive regulation of long-term synaptic potentiation uc007zfp.1 uc007zfp.2 uc007zfp.3 uc007zfp.4 
ENSMUST00000023482.13 B4galt4 ENSMUST00000023482.13 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4, transcript variant 2 (from RefSeq NM_019804.4) B4GT4_MOUSE B4galt4 ENSMUST00000023482.1 ENSMUST00000023482.10 ENSMUST00000023482.11 ENSMUST00000023482.12 ENSMUST00000023482.2 ENSMUST00000023482.3 ENSMUST00000023482.4 ENSMUST00000023482.5 ENSMUST00000023482.6 ENSMUST00000023482.7 ENSMUST00000023482.8 ENSMUST00000023482.9 NM_019804 Q8BR54 Q9JJ04 Q9QY12 uc007zfj.1 uc007zfj.2 uc007zfj.3 uc007zfj.4 uc007zfj.5 Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids. Catalyzes the transfer of Gal residue via a beta1->4 linkage from UDP-Gal to the non-reducing terminal N-acetyl glucosamine 6-O-sulfate (6-O-sulfoGlcNAc) in the linearly growing chain of both N- and O-linked keratan sulfate proteoglycans. Cooperates with B3GNT7 N-acetyl glucosamine transferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6- sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6- sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Transfers Gal residue via a beta1->4 linkage to terminal 6-O-sulfoGlcNAc within the LacNac unit of core 2 O-glycans forming 6-sulfo-sialyl-Lewis X (sLex). May contribute to the generation of sLex epitope on mucin-type glycoproteins that serve as ligands for SELL/L-selectin, a major regulator of leukocyte migration. In the biosynthesis pathway of neolacto-series glycosphingolipids, transfers Gal residue via a beta1->4 linkage to terminal GlcNAc of a lactotriaosylceramide (Lc3Cer) acceptor to form a neolactotetraosylceramide. Reaction=N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D- galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP; Xref=Rhea:RHEA:17745, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:60152, ChEBI:CHEBI:66914, ChEBI:CHEBI:506227; EC=2.4.1.90; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17746; Evidence=; Reaction=a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)- Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:31499, ChEBI:CHEBI:15378, ChEBI:CHEBI:17006, ChEBI:CHEBI:17103, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914; EC=2.4.1.275; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31500; Evidence=; Reaction=3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D- glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl- [protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)- [beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl- (1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:67948, Rhea:RHEA-COMP:17367, Rhea:RHEA- COMP:17398, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:176494, ChEBI:CHEBI:176635; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67949; Evidence=; Reaction=3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D- glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl- [protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)- [beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl- (1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:67872, Rhea:RHEA-COMP:17370, Rhea:RHEA- COMP:17397, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:176493, ChEBI:CHEBI:176634; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67873; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Glycolipid biosynthesis. Interacts with SLC35A2/UGT1. Golgi apparatus membrane ; Single-pass type II membrane protein Secreted Belongs to the glycosyltransferase 7 family. Sequence=BAC32433.1; Type=Frameshift; Evidence=; Name=Functional Glycomics Gateway - GTase; Note=b4GalT4; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_463"; molecular_function N-acetyllactosamine synthase activity Golgi apparatus carbohydrate metabolic process protein glycosylation biological_process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups Golgi cisterna membrane metal ion binding uc007zfj.1 uc007zfj.2 uc007zfj.3 uc007zfj.4 uc007zfj.5 
ENSMUST00000023486.15 Tfrc ENSMUST00000023486.15 transferrin receptor, transcript variant 1 (from RefSeq NM_011638.4) ENSMUST00000023486.1 ENSMUST00000023486.10 ENSMUST00000023486.11 ENSMUST00000023486.12 ENSMUST00000023486.13 ENSMUST00000023486.14 ENSMUST00000023486.2 ENSMUST00000023486.3 ENSMUST00000023486.4 ENSMUST00000023486.5 ENSMUST00000023486.6 ENSMUST00000023486.7 ENSMUST00000023486.8 ENSMUST00000023486.9 NM_011638 Q61560 Q62351 TFR1_MOUSE Trfr uc007yza.1 uc007yza.2 uc007yza.3 uc007yza.4 This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis. [provided by RefSeq, Sep 2015]. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Upon stimulation, positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity). Homodimer; disulfide-linked. Binds one transferrin molecule per subunit. Interacts with SH3BP4 (By similarity). Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells (By similarity). Cell membrane ; Single-pass type II membrane protein Melanosome Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation (By similarity). Stearoylation does not affect iron uptake (By similarity). N- and O-glycosylated, phosphorylated and palmitoylated. Belongs to the peptidase M28 family. M28B subfamily. double-stranded RNA binding transferrin receptor activity iron ion transmembrane transporter activity protein binding extracellular region extracellular space nucleus cytoplasm mitochondrion endosome early endosome plasma membrane integral component of plasma membrane clathrin-coated pit iron ion transport cellular iron ion homeostasis endocytosis receptor-mediated endocytosis external side of plasma membrane cell surface endosome membrane membrane integral component of membrane basolateral plasma membrane osteoclast differentiation Hsp70 protein binding positive regulation of B cell proliferation cytoplasmic vesicle receptor internalization cellular response to extracellular stimulus transferrin transport iron ion transmembrane transport cellular response to drug positive regulation of T cell proliferation melanosome identical protein binding protein homodimerization activity positive regulation of bone resorption positive regulation of isotype switching perinuclear region of cytoplasm chaperone binding recycling endosome recycling endosome membrane extracellular exosome cellular response to iron ion HFE-transferrin receptor complex cellular response to leukemia inhibitory factor uc007yza.1 uc007yza.2 uc007yza.3 uc007yza.4 
ENSMUST00000023487.5 Arhgap31 ENSMUST00000023487.5 Rho GTPase activating protein 31 (from RefSeq NM_020260.2) Arhgap31 B2RSI0 B2RSI0_MOUSE Cdgap ENSMUST00000023487.1 ENSMUST00000023487.2 ENSMUST00000023487.3 ENSMUST00000023487.4 NM_020260 uc007zfg.1 uc007zfg.2 uc007zfg.3 signal transduction uc007zfg.1 uc007zfg.2 uc007zfg.3 
ENSMUST00000023489.11 Fyttd1 ENSMUST00000023489.11 forty-two-three domain containing 1, transcript variant 1 (from RefSeq NM_027226.4) ENSMUST00000023489.1 ENSMUST00000023489.10 ENSMUST00000023489.2 ENSMUST00000023489.3 ENSMUST00000023489.4 ENSMUST00000023489.5 ENSMUST00000023489.6 ENSMUST00000023489.7 ENSMUST00000023489.8 ENSMUST00000023489.9 NM_027226 Q3TJ68 Q3UT89 Q8BVM8 Q8K361 Q91Z49 Q921B0 Q9D6A8 UIF_MOUSE Uif uc007yzp.1 uc007yzp.2 uc007yzp.3 uc007yzp.4 Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4 (By similarity). Interacts with DDX39B/UAP56 and NXF1; interaction with DDX39B/UAP56 and NXF1 are mutually exclusive. Interacts with SSRP1; required for its recruitment to mRNAs (By similarity). Interacts with CHTOP. Nucleus, nucleoplasm Nucleus speckle Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q91Z49-1; Sequence=Displayed; Name=2; IsoId=Q91Z49-2; Sequence=VSP_025463, VSP_025464; Name=3; IsoId=Q91Z49-3; Sequence=VSP_025462; Belongs to the UIF family. RNA binding mRNA binding nucleus nucleoplasm mRNA export from nucleus nuclear speck mRNA transport uc007yzp.1 uc007yzp.2 uc007yzp.3 uc007yzp.4 
ENSMUST00000023494.13 Popdc2 ENSMUST00000023494.13 popeye domain containing 2, transcript variant 1 (from RefSeq NM_001081984.2) ENSMUST00000023494.1 ENSMUST00000023494.10 ENSMUST00000023494.11 ENSMUST00000023494.12 ENSMUST00000023494.2 ENSMUST00000023494.3 ENSMUST00000023494.4 ENSMUST00000023494.5 ENSMUST00000023494.6 ENSMUST00000023494.7 ENSMUST00000023494.8 ENSMUST00000023494.9 NM_001081984 Popdc2 Q6P3F7 Q6P3F7_MOUSE uc007zev.1 uc007zev.2 uc007zev.3 uc007zev.4 This gene encodes a member of the Popeye domain containing family of membrane proteins. Proteins of this family contain three helical transmembrane domains and a conserved intracellular Popeye domain. In the adult mouse, this gene is expressed at high levels in cardiac myocytes, and mice deficient for this gene develop stress-induced cardiac pacemaker dysfunction. The protein binds to a two-pore domain potassium channel and recruits it to the plasma membrane. Cyclic adenosine monophosphate negatively regulates this interaction through the Popeye domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. Belongs to the popeye family. membrane integral component of membrane sarcolemma uc007zev.1 uc007zev.2 uc007zev.3 uc007zev.4 
ENSMUST00000023497.3 Lmln ENSMUST00000023497.3 leishmanolysin-like (metallopeptidase M8 family) (from RefSeq NM_172823.2) ENSMUST00000023497.1 ENSMUST00000023497.2 LMLN_MOUSE NM_172823 Q8BMN4 uc007yzx.1 uc007yzx.2 uc007yzx.3 Metalloprotease. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Cytoplasm. Lipid droplet Note=Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells (By similarity). Belongs to the peptidase M8 family. metalloendopeptidase activity cytoplasm lipid particle cytosol focal adhesion proteolysis cell cycle cell adhesion peptidase activity metallopeptidase activity membrane hydrolase activity metal ion binding cell division uc007yzx.1 uc007yzx.2 uc007yzx.3 
ENSMUST00000023502.6 Snx4 ENSMUST00000023502.6 sorting nexin 4 (from RefSeq NM_080557.2) ENSMUST00000023502.1 ENSMUST00000023502.2 ENSMUST00000023502.3 ENSMUST00000023502.4 ENSMUST00000023502.5 NM_080557 Q91YJ2 SNX4_MOUSE Snx4 uc007yzz.1 uc007yzz.2 uc007yzz.3 Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A. Heterodimer; heterodimerizes with SNX7 or SNX30 (By similarity). Interacts with WWC1/KIBRA (By similarity). Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2 (By similarity). Interacts with BIN1 (PubMed:12668730). Early endosome Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC). The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization. Belongs to the sorting nexin family. epidermal growth factor receptor binding insulin receptor binding cytoplasm endosome early endosome cytoplasmic dynein complex plasma membrane lipid binding protein transport membrane SNARE complex early endosome membrane endocytic recycling macromolecular complex phosphatidylinositol binding positive regulation of histamine secretion by mast cell transferrin receptor binding leptin receptor binding uc007yzz.1 uc007yzz.2 uc007yzz.3 
ENSMUST00000023504.5 Nr1i2 ENSMUST00000023504.5 nuclear receptor subfamily 1, group I, member 2, transcript variant 3 (from RefSeq NR_189595.1) ENSMUST00000023504.1 ENSMUST00000023504.2 ENSMUST00000023504.3 ENSMUST00000023504.4 NR_189595 Nr1i2 Q0P525 Q0P525_MOUSE uc007zeq.1 uc007zeq.2 uc007zeq.3 Nucleus Belongs to the nuclear hormone receptor family. NR1 subfamily. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated xenobiotic metabolic process drug binding zinc ion binding nuclear body intracellular receptor signaling pathway exogenous drug catabolic process xenobiotic transport steroid hormone mediated signaling pathway sequence-specific DNA binding intermediate filament cytoskeleton negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter drug export metal ion binding uc007zeq.1 uc007zeq.2 uc007zeq.3 
ENSMUST00000023507.13 Gsk3b ENSMUST00000023507.13 glycogen synthase kinase 3 beta, transcript variant 1 (from RefSeq NM_019827.7) ENSMUST00000023507.1 ENSMUST00000023507.10 ENSMUST00000023507.11 ENSMUST00000023507.12 ENSMUST00000023507.2 ENSMUST00000023507.3 ENSMUST00000023507.4 ENSMUST00000023507.5 ENSMUST00000023507.6 ENSMUST00000023507.7 ENSMUST00000023507.8 ENSMUST00000023507.9 GSK3B_MOUSE Gsk3b NM_019827 Q9WV60 uc007zen.1 uc007zen.2 uc007zen.3 Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1 (PubMed:15791206, PubMed:22057101, PubMed:23395175). Requires primed phosphorylation of the majority of its substrates (PubMed:15791206, PubMed:22057101, PubMed:23395175). In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (By similarity). Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (By similarity). In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (By similarity). Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA (By similarity). Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin (By similarity). Phosphorylates MAPT/TAU on 'Thr- 548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules (By similarity). MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease (By similarity). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair (PubMed:21295697). Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF- alpha (TNF/TNFA) (PubMed:10894547). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (PubMed:18288891). Through phosphorylation of the anti- apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (PubMed:16543145). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (PubMed:17391670). Phosphorylates MARK2, leading to inhibition of its activity (By similarity). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity (By similarity). Phosphorylates ZC3HAV1 which enhances its antiviral activity (By similarity). Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation (By similarity). Phosphorylates SFPQ at 'Thr-687' upon T-cell activation (By similarity). Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation (By similarity). Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2 (PubMed:20049328, PubMed:28556462, PubMed:28903391, PubMed:20123978). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (By similarity). Phosphorylates BMAL1 at 'Ser-17' and 'Ser- 21' and primes it for ubiquitination and proteasomal degradation (PubMed:20049328, PubMed:28903391). Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation (PubMed:23542741). Phosphorylates OGT at 'Ser- 3' or 'Ser-4' which positively regulates its activity (By similarity). Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (By similarity). Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (PubMed:28556462). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:22539723). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors (By similarity). Promotes the formation of an anti- apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B (By similarity). The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity (By similarity). Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (PubMed:26240334, PubMed:29142209). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (PubMed:24742671). Reaction=ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl- [tau protein]; Xref=Rhea:RHEA:12801, Rhea:RHEA-COMP:13701, Rhea:RHEA- COMP:13702, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.26; Evidence=; Reaction=ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L- threonyl-[tau protein]; Xref=Rhea:RHEA:53904, Rhea:RHEA-COMP:13703, Rhea:RHEA-COMP:13704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.26; Evidence=; Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Activated by phosphorylation at Tyr-216. In response to insulin, inhibited by phosphorylation at Ser-9 by PKB/AKT1 and RPS6KA3; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site (By similarity). Inhibited by IL22 treatment which also triggers phosphorylation at Ser-9, promoting inactivation (PubMed:24742671). Inhibited by lithium (By similarity). Monomer (By similarity). Interacts with DAB2IP (via C2 domain); the interaction stimulates GSK3B kinase activation (By similarity). Interacts (via C2 domain) with PPP2CA (By similarity). Interacts with CABYR, MMP2, MUC1, NIN and PRUNE1 (By similarity). Interacts with AXIN1; the interaction mediates hyperphosphorylation of CTNNB1 leading to its ubiquitination and destruction (PubMed:19141611). Interacts with and phosphorylates SNAI1 (By similarity). Interacts with DNM1L (via a C-terminal domain) (By similarity). Interacts with ARRB2 (PubMed:16051150). Interacts with DISC1 (PubMed:19303846). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Interacts with SGK3 (By similarity). Interacts with the CLOCK-BMAL1 heterodimer (By similarity). Interacts with ZBED3 (PubMed:19141611). Interacts with the BMAL1 (PubMed:20049328, PubMed:28903391). The complex composed, at least, of APC, CTNNB1 and GSK3B interacts with JPT1; the interaction requires the inactive form of GSK3B (phosphorylated at 'Ser-9') (By similarity). Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation and regulates GSK3B activity (By similarity). Interacts with GSKIP (By similarity). Interacts with GID8 (By similarity). Interacts with PIWIL2 (PubMed:28903391). Interacts with LMBR1L (PubMed:31073040). Interacts with DDX3X (By similarity). Interacts with BIRC2 (By similarity). Interacts with TNFRSF10B; TNFRSF10B stimulation inhibits GSK3B kinase activity (By similarity). Found in a complex with SLC39A6, SLC39A10 and with GSK3B that controls NCAM1 phosphorylation (PubMed:28098160). Q9WV60; Q02248: Ctnnb1; NbExp=2; IntAct=EBI-400793, EBI-397872; Q9WV60; Q9WUA5: Epm2a; NbExp=2; IntAct=EBI-400793, EBI-1040928; Cytoplasm Nucleus Cell membrane Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (By similarity). Expressed in the liver (at protein level). Phosphorylated by AKT1 and ILK1. Upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and deactivates GSK3B, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-216. Phosphorylation of Ser-9 in the hippocampus peaks at CT0, whereas in the liver it peaks at CT12. Inactivated by phosphorylation at Ser-9 (By similarity). Phosphorylated in a circadian manner in the hippocampus (PubMed:28556462). Mono-ADP-ribosylation by PARP10 negatively regulates kinase activity. Embryonic lethality at 16 dpc due to hepatocyte apoptosis. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. nucleotide binding re-entry into mitotic cell cycle RNA polymerase II transcription factor binding regulation of cell growth epithelial to mesenchymal transition positive regulation of cell-matrix adhesion protease binding p53 binding protein kinase activity protein serine/threonine kinase activity integrin binding protein binding ATP binding nucleus nucleoplasm cytoplasm mitochondrion centrosome cytosol microtubule plasma membrane carbohydrate metabolic process glycogen metabolic process regulation of gene expression by genetic imprinting protein phosphorylation protein export from nucleus ER overload response cytoskeleton organization establishment or maintenance of cell polarity signal transduction multicellular organism development nervous system development axonogenesis myoblast fusion circadian rhythm beta-catenin binding transcription factor binding insulin receptor signaling pathway animal organ morphogenesis negative regulation of signal transduction response to zinc ion positive regulation of autophagy negative regulation of cardiac muscle hypertrophy positive regulation of gene expression positive regulation of peptidyl-threonine phosphorylation positive regulation of mitochondrion organization positive regulation of mitochondrial membrane potential regulation of neuron projection development negative regulation of neuron projection development negative regulation of neuron maturation postsynaptic density myotube differentiation membrane Wnt signaling pathway kinase activity phosphorylation cell migration transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation protein kinase binding hippocampus development establishment of cell polarity maintenance of cell polarity cell differentiation axon dendrite growth cone regulation of axon extension beta-catenin destruction complex neuron projection development negative regulation of protein complex assembly positive regulation of protein complex assembly ubiquitin protein ligase binding negative regulation of TOR signaling negative regulation of protein binding positive regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of microtubule-based process macromolecular complex positive regulation of osteoblast proliferation protein kinase A catalytic subunit binding negative regulation of smooth muscle cell apoptotic process dynactin binding ionotropic glutamate receptor binding protein localization to microtubule intracellular signal transduction cellular response to hepatocyte growth factor stimulus hepatic stellate cell activation cellular response to interleukin-3 regulation of circadian rhythm regulation of apoptotic process neuronal cell body positive regulation of apoptotic process negative regulation of apoptotic process dendritic spine dendritic shaft membrane-bounded organelle negative regulation of MAP kinase activity positive regulation of neuron apoptotic process positive regulation of GTPase activity hypermethylation of CpG island cell body membrane raft fat cell differentiation regulation of osteoblast differentiation positive regulation of osteoclast differentiation positive regulation of protein catabolic process positive regulation of axon extension positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation positive regulation of protein export from nucleus bone remodeling tau protein binding regulation of neuronal synaptic plasticity perinuclear region of cytoplasm rhythmic process positive regulation of smooth muscle cell proliferation regulation of dendrite morphogenesis tau-protein kinase activity regulation of axonogenesis negative regulation of dendrite morphogenesis negative regulation of nitric-oxide synthase activity NF-kappaB binding canonical Wnt signaling pathway cell growth involved in cardiac muscle cell development intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of microtubule cytoskeleton organization dynein complex binding negative regulation of calcineurin-NFAT signaling cascade superior temporal gyrus development cellular response to mechanical stimulus negative regulation of canonical Wnt signaling pathway positive regulation of osteoclast proliferation extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand hepatocyte apoptotic process glutamatergic synapse negative regulation of protein localization to nucleus regulation of long-term synaptic potentiation positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway negative regulation of neuron death positive regulation of neuron death negative regulation of protein acetylation negative regulation of dopaminergic neuron differentiation cellular response to beta-amyloid negative regulation of protein localization to centrosome positive regulation of protein localization to centrosome ribonucleoprotein complex Wnt signalosome negative regulation of dendrite development regulation of synaptic vesicle exocytosis positive regulation of excitatory postsynaptic potential positive regulation of DNA biosynthetic process positive regulation of cardiac muscle cell differentiation positive regulation of stem cell differentiation negative regulation of neuron migration uc007zen.1 uc007zen.2 uc007zen.3 
ENSMUST00000023509.5 Klhl24 ENSMUST00000023509.5 kelch-like 24 (from RefSeq NM_029436.3) ENSMUST00000023509.1 ENSMUST00000023509.2 ENSMUST00000023509.3 ENSMUST00000023509.4 KLH24_MOUSE NM_029436 Q3TQG0 Q78J30 Q8BQU1 Q8BRG6 Q9D5K3 uc007yph.1 uc007yph.2 uc007yph.3 Controls KRT14 levels during keratinocytes differentiation (PubMed:27798626). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 (By similarity). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). Has a crucial role in cardiac development and function (By similarity). Forms homodimers. Interacts with GRIK2 (By similarity). Component of the BCR(KLHL24) E3 ubiquitin ligase complex, composed of CUL3, RBX1 and KLHL24. Interacts with CUL3. Interacts with KRT14 (By similarity). Perikaryon Cell projection, axon Cytoplasm Cell junction, desmosome Cell junction, adherens junction Expressed in the brain. Autoubiquitinated. Autoubiquitination leads to proteasomal degradation and is necessary to control KLHL24 levels. Sequence=AAH21407.2; Type=Erroneous initiation; Evidence=; Sequence=BAB29759.2; Type=Erroneous initiation; Evidence=; Sequence=BAE37423.1; Type=Erroneous initiation; Evidence=; cytoplasm adherens junction protein ubiquitination cell junction desmosome axon Cul3-RING ubiquitin ligase complex cell projection perikaryon intermediate filament organization protein autoubiquitination regulation of kainate selective glutamate receptor activity uc007yph.1 uc007yph.2 uc007yph.3 
ENSMUST00000023510.7 Umps ENSMUST00000023510.7 uridine monophosphate synthetase, transcript variant 1 (from RefSeq NM_009471.3) ENSMUST00000023510.1 ENSMUST00000023510.2 ENSMUST00000023510.3 ENSMUST00000023510.4 ENSMUST00000023510.5 ENSMUST00000023510.6 NM_009471 Q544K9 Q544K9_MOUSE Umps uc007zap.1 uc007zap.2 uc007zap.3 Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. In the C-terminal section; belongs to the OMP decarboxylase family. In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. catalytic activity orotate phosphoribosyltransferase activity orotidine-5'-phosphate decarboxylase activity nucleus cytoplasm 'de novo' pyrimidine nucleobase biosynthetic process pyrimidine nucleotide biosynthetic process UMP biosynthetic process female pregnancy lactation nucleoside metabolic process cellular response to drug 'de novo' UMP biosynthetic process uc007zap.1 uc007zap.2 uc007zap.3 
ENSMUST00000023514.4 Ndufb4 ENSMUST00000023514.4 NADH:ubiquinone oxidoreductase subunit B4 (from RefSeq NM_026610.2) ENSMUST00000023514.1 ENSMUST00000023514.2 ENSMUST00000023514.3 NDUB4_MOUSE NM_026610 Q9CQC7 uc007zei.1 uc007zei.2 uc007zei.3 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side Belongs to the complex I NDUFB4 subunit family. molecular_function mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I response to oxidative stress NADH dehydrogenase (ubiquinone) activity membrane integral component of membrane nuclear membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc007zei.1 uc007zei.2 uc007zei.3 
ENSMUST00000023524.13 Rabl3 ENSMUST00000023524.13 RAB, member RAS oncogene family-like 3 (from RefSeq NM_001042499.1) ENSMUST00000023524.1 ENSMUST00000023524.10 ENSMUST00000023524.11 ENSMUST00000023524.12 ENSMUST00000023524.2 ENSMUST00000023524.3 ENSMUST00000023524.4 ENSMUST00000023524.5 ENSMUST00000023524.6 ENSMUST00000023524.7 ENSMUST00000023524.8 ENSMUST00000023524.9 NM_001042499 Q8BMU2 Q9D0M6 Q9D4V7 RABL3_MOUSE uc007zed.1 uc007zed.2 uc007zed.3 Required for KRAS signaling regulation and modulation of cell proliferation (PubMed:31406347). Regulator of KRAS prenylation, and probably prenylation of other small GTPases (By similarity). Required for lymphocyte development and function (PubMed:32220963). Not required for myeloid cell development (PubMed:32220963). Homodimer (PubMed:32220963). Interacts with GPR89; the interaction stabilizes GPR89 (PubMed:32220963). Interacts with RAP1GDS1 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D4V7-1; Sequence=Displayed; Name=2; IsoId=Q9D4V7-2; Sequence=VSP_029723; Embryonic lethal. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity GTP binding cell intracellular protein transport Rab protein signal transduction uc007zed.1 uc007zed.2 uc007zed.3 
ENSMUST00000023525.9 Gtf2e1 ENSMUST00000023525.9 general transcription factor II E, polypeptide 1 (alpha subunit), transcript variant 1 (from RefSeq NM_028812.4) ENSMUST00000023525.1 ENSMUST00000023525.2 ENSMUST00000023525.3 ENSMUST00000023525.4 ENSMUST00000023525.5 ENSMUST00000023525.6 ENSMUST00000023525.7 ENSMUST00000023525.8 NM_028812 Q544T0 Q9D0D5 T2EA_MOUSE uc007zeb.1 uc007zeb.2 uc007zeb.3 Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80. Interacts with ATF7IP. Interacts with SND1. Nucleus Belongs to the TFIIE alpha subunit family. RNA polymerase II core binding TFIIH-class transcription factor binding transcriptional open complex formation at RNA polymerase II promoter nucleus transcription factor TFIID complex transcription factor TFIIE complex cytosol transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter obsolete general RNA polymerase II transcription factor activity metal ion binding transcriptional preinitiation complex uc007zeb.1 uc007zeb.2 uc007zeb.3 
ENSMUST00000023530.5 Ropn1 ENSMUST00000023530.5 ropporin, rhophilin associated protein 1, transcript variant 1 (from RefSeq NM_030744.3) ENSMUST00000023530.1 ENSMUST00000023530.2 ENSMUST00000023530.3 ENSMUST00000023530.4 NM_030744 Q3TVG5 Q9ESG2 ROP1_MOUSE uc007zaz.1 uc007zaz.2 uc007zaz.3 Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Homodimer. Interacts with AKAP3 (By similarity). May interact with SPA17 (By similarity). Interacts with RHPN1 (PubMed:10591629). Interacts with FSCB; the interaction increases upon spermatozoa capacitation conditions (PubMed:27398160). Cell projection, cilium, flagellum Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath. Testis-specific. Present in the most inner parts of seminiferous tubules (at protein level). Expression in testis starts at P21, and increases to reach a plateau at P27 (PubMed:10591629). Expressed in the flagella of sperm at all stages of development in the testis and epididymis (PubMed:23303679). The RIIa domain mediates interaction with AKAP3. Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions. Mutant mice are subfertile with normal testicular morphology and spermatogenesis but moderately impaired motility and increased levels of ROPN1L (PubMed:23303679). Double knockout animals for ROPN1 and ROPN1L are infertile with normal testicular morphology and spermatogenesis but defects in sperm morphology, thinning and shredding of the principal piece. Sperm is immotile (PubMed:23303679). 'Ropporin' comes from the Japanese word 'oppo' which means 'tail'. Belongs to the ropporin family. regulation of protein phosphorylation protein binding cytoplasm cytosol cilium flagellated sperm motility motile cilium identical protein binding cell projection cilium organization sperm capacitation protein localization to cilium sperm principal piece sperm cytoplasmic droplet uc007zaz.1 uc007zaz.2 uc007zaz.3 
ENSMUST00000023531.15 Hcls1 ENSMUST00000023531.15 hematopoietic cell specific Lyn substrate 1 (from RefSeq NM_008225.2) ENSMUST00000023531.1 ENSMUST00000023531.10 ENSMUST00000023531.11 ENSMUST00000023531.12 ENSMUST00000023531.13 ENSMUST00000023531.14 ENSMUST00000023531.2 ENSMUST00000023531.3 ENSMUST00000023531.4 ENSMUST00000023531.5 ENSMUST00000023531.6 ENSMUST00000023531.7 ENSMUST00000023531.8 ENSMUST00000023531.9 HCLS1_MOUSE Hs1 NM_008225 P49710 Q922I8 uc007zdi.1 uc007zdi.2 uc007zdi.3 uc007zdi.4 Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression (By similarity). Interacts (via SH2 domain) with FGR (By similarity). Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. Interacts with FES/FPS. Forms a multiprotein complex with LYN and ANKRD54. P49710; P25911: Lyn; NbExp=10; IntAct=EBI-924601, EBI-643537; Mitochondrion Expressed only in tissues and cells of hematopoietic origin. Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK (By similarity). Binds to LCK in vivo, and is tyrosine phosphorylated upon TCR stimulation. Phosphorylated by FES. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding actin binding protein binding nucleus transcription factor complex cytoplasm mitochondrion cytosol plasma membrane positive regulation of cell proliferation response to hormone positive regulation of phosphatidylinositol 3-kinase signaling postsynaptic density SH3 domain binding protein kinase binding lamellipodium actin filament polymerization erythrocyte differentiation dendrite site of polarized growth regulation of actin filament polymerization positive regulation of granulocyte differentiation cortical actin cytoskeleton positive regulation of peptidyl-serine phosphorylation positive regulation of protein import into nucleus positive regulation of tyrosine phosphorylation of STAT protein macromolecular complex binding postsynaptic membrane positive regulation of macrophage differentiation positive regulation of axon extension positive regulation of transcription from RNA polymerase II promoter neuron projection morphogenesis positive regulation of peptidyl-tyrosine phosphorylation actin filament binding positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of protein kinase B signaling positive regulation of dendritic spine morphogenesis cellular response to cytokine stimulus postsynaptic actin cytoskeleton organization negative regulation of leukocyte apoptotic process actin filament uc007zdi.1 uc007zdi.2 uc007zdi.3 uc007zdi.4 
ENSMUST00000023532.7 Ccdc14 ENSMUST00000023532.7 Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. (from UniProt Q8K2J4) BC095999 CCD14_MOUSE ENSMUST00000023532.1 ENSMUST00000023532.2 ENSMUST00000023532.3 ENSMUST00000023532.4 ENSMUST00000023532.5 ENSMUST00000023532.6 Q8BJ89 Q8K2J4 uc007zbb.1 uc007zbb.2 uc007zbb.3 Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. Interacts with CEP63. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Note=Colocalizes with PCM1 at centriolar satellites throughout the cell cycle. Sequence=AAH31204.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH31204.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence=; Sequence=BAC41158.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton centriolar satellite protein localization to centrosome uc007zbb.1 uc007zbb.2 uc007zbb.3 
ENSMUST00000023535.4 Iqcb1 ENSMUST00000023535.4 IQ calmodulin-binding motif containing 1 (from RefSeq NM_177128.4) ENSMUST00000023535.1 ENSMUST00000023535.2 ENSMUST00000023535.3 IQCB1_MOUSE Kiaa0036 NM_177128 Q3TNK4 Q8BP00 Q8K306 uc007zdb.1 uc007zdb.2 uc007zdb.3 uc007zdb.4 uc007zdb.5 Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (By similarity). Interacts with calmodulin (PubMed:15723066). Interacts with CEP290/NPHP6; IQCB1/NPHP5 and CEP290/NPHP6; are proposed to form a functional NPHP5-6 module localized to the centrosome. Interacts with ATXN10. Interacts with NPHP1, INVS, NPHP4 and RPGRIP1L; these interactions likely require additional interactors (PubMed:21565611). Associates with the BBSome complex; interacts with BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9 (By similarity). Q8BP00; P28658: Atxn10; NbExp=2; IntAct=EBI-4282243, EBI-4284019; Q8BP00; Q6A078: Cep290; NbExp=6; IntAct=EBI-4282243, EBI-1811999; Q8BP00; O89019: Invs; NbExp=2; IntAct=EBI-4282243, EBI-4281337; Q8BP00; Q8CG73: Rpgrip1l; NbExp=2; IntAct=EBI-4282243, EBI-4281130; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localization to the centrosome depends on the interaction with CEP290. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BP00-1; Sequence=Displayed; Name=2; IsoId=Q8BP00-2; Sequence=VSP_010246; Localized to the outer segment and connecting cilia of photoreceptor cells. The IQ domains mediate the interaction with calmodulin. photoreceptor outer segment protein binding calmodulin binding nucleoplasm cytoplasm centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton enzyme binding cell projection organization photoreceptor connecting cilium intercellular bridge photoreceptor cell maintenance maintenance of animal organ identity cilium assembly mitotic spindle uc007zdb.1 uc007zdb.2 uc007zdb.3 uc007zdb.4 uc007zdb.5 
ENSMUST00000023538.9 Mylk ENSMUST00000023538.9 myosin, light polypeptide kinase, transcript variant 2 (from RefSeq NM_139300.4) B1B1A8 B1B1A8_MOUSE ENSMUST00000023538.1 ENSMUST00000023538.2 ENSMUST00000023538.3 ENSMUST00000023538.4 ENSMUST00000023538.5 ENSMUST00000023538.6 ENSMUST00000023538.7 ENSMUST00000023538.8 Mylk NM_139300 uc007zbd.1 uc007zbd.2 uc007zbd.3 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding stress fiber protein kinase activity myosin light chain kinase activity ATP binding cytoplasm plasma membrane protein phosphorylation actin cytoskeleton kinase activity phosphorylation transferase activity lamellipodium positive regulation of cell migration bleb assembly cleavage furrow positive regulation of calcium ion transport aorta smooth muscle tissue morphogenesis cellular hypotonic response positive regulation of wound healing uc007zbd.1 uc007zbd.2 uc007zbd.3 
ENSMUST00000023550.9 Pdia5 ENSMUST00000023550.9 protein disulfide isomerase associated 5 (from RefSeq NM_028295.1) ENSMUST00000023550.1 ENSMUST00000023550.2 ENSMUST00000023550.3 ENSMUST00000023550.4 ENSMUST00000023550.5 ENSMUST00000023550.6 ENSMUST00000023550.7 ENSMUST00000023550.8 NM_028295 PDIA5_MOUSE Pdir Q921X9 uc007zbl.1 uc007zbl.2 Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; Interacts with CALR (via P-domain). Endoplasmic reticulum lumen Belongs to the protein disulfide isomerase family. protein disulfide isomerase activity endoplasmic reticulum endoplasmic reticulum lumen peptide disulfide oxidoreductase activity isomerase activity cell redox homeostasis oxidation-reduction process uc007zbl.1 uc007zbl.2 
ENSMUST00000023554.9 Slc49a4 ENSMUST00000023554.9 solute carrier family 49 member 4 (from RefSeq NM_153550.4) DIRC2_MOUSE Dirc2 ENSMUST00000023554.1 ENSMUST00000023554.2 ENSMUST00000023554.3 ENSMUST00000023554.4 ENSMUST00000023554.5 ENSMUST00000023554.6 ENSMUST00000023554.7 ENSMUST00000023554.8 NM_153550 Q8BFQ6 uc007zbo.1 uc007zbo.2 uc007zbo.3 Mediates H(+)-dependent pyridoxine transport. Reaction=n H(+)(out) + pyridoxine(out) = n H(+)(in) + pyridoxine(in); Xref=Rhea:RHEA:76203, ChEBI:CHEBI:15378, ChEBI:CHEBI:16709; Evidence=; Lysosome membrane ; Multi-pass membrane protein Cleaved in lysosomes by cathepsin L between Leu-214 and Ala-261, generating a N-glycosylated N-terminal and a non-glycosylated C- terminal fragment. Belongs to the major facilitator superfamily. molecular_function lysosome lysosomal membrane biological_process membrane integral component of membrane intracellular membrane-bounded organelle uc007zbo.1 uc007zbo.2 uc007zbo.3 
ENSMUST00000023559.7 Ehhadh ENSMUST00000023559.7 enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (from RefSeq NM_023737.3) ECHP_MOUSE ENSMUST00000023559.1 ENSMUST00000023559.2 ENSMUST00000023559.3 ENSMUST00000023559.4 ENSMUST00000023559.5 ENSMUST00000023559.6 Ehhadh L-pbe NM_023737 Q91W49 Q9DBM2 uc007yrm.1 uc007yrm.2 uc007yrm.3 uc007yrm.4 Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl- CoA isomerase activities. Catalyzes two of the four reactions of the long chain fatty acids peroxisomal beta-oxidation pathway (PubMed:17442273, PubMed:24075987). Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA (By similarity). Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species. Also able to isomerize both 3-cis and 3- trans double bonds into the 2-trans form in a range of enoyl-CoA species (By similarity). With HSD17B4, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (Probable). Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (PubMed:24075987). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (By similarity). Reaction=a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O; Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318, ChEBI:CHEBI:58856; EC=4.2.1.17; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:16107; Evidence=; Reaction=a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O; Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521, ChEBI:CHEBI:137480; EC=4.2.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20725; Evidence=; Reaction=a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA; Xref=Rhea:RHEA:45900, ChEBI:CHEBI:85097, ChEBI:CHEBI:85489; EC=5.3.3.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45901; Evidence=; Reaction=a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA; Xref=Rhea:RHEA:45228, ChEBI:CHEBI:58521, ChEBI:CHEBI:85097; EC=5.3.3.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45229; Evidence=; Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22433; Evidence=; Reaction=(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2- enoyl-CoA + H2O; Xref=Rhea:RHEA:31119, ChEBI:CHEBI:15377, ChEBI:CHEBI:57312, ChEBI:CHEBI:57337; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31121; Evidence=; Reaction=(2E)-dodecenedioyl-CoA + H2O = (3S)-hydroxydodecanedioyl-CoA; Xref=Rhea:RHEA:39075, ChEBI:CHEBI:15377, ChEBI:CHEBI:76340, ChEBI:CHEBI:76342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39076; Evidence=; Reaction=(3S)-hydroxydodecanedioyl-CoA + NAD(+) = 3-oxododecanedioyl- CoA + H(+) + NADH; Xref=Rhea:RHEA:39079, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76342, ChEBI:CHEBI:76346; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39080; Evidence=; Reaction=(2E)-octenedioyl-CoA + H2O = (3S)-hydroxyoctanedioyl-CoA; Xref=Rhea:RHEA:22532, ChEBI:CHEBI:15377, ChEBI:CHEBI:76330, ChEBI:CHEBI:76333; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22533; Evidence=; Reaction=(3S)-hydroxyoctanedioyl-CoA + NAD(+) = 3-oxooctanedioyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:22848, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76333, ChEBI:CHEBI:76335; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22849; Evidence=; Reaction=(2E)-decenedioyl-CoA + H2O = (3S)-hydroxydecanedioyl-CoA; Xref=Rhea:RHEA:39091, ChEBI:CHEBI:15377, ChEBI:CHEBI:76347, ChEBI:CHEBI:76348; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39092; Evidence=; Reaction=(3S)-hydroxydecanedioyl-CoA + NAD(+) = 3-oxodecanedioyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:39095, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76348, ChEBI:CHEBI:76349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39096; Evidence=; Reaction=(2E)-tetradecenedioyl-CoA + H2O = (3S)- hydroxytetradecanedioyl-CoA; Xref=Rhea:RHEA:40207, ChEBI:CHEBI:15377, ChEBI:CHEBI:77038, ChEBI:CHEBI:77039; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40208; Evidence=; Reaction=(3S)-hydroxytetradecanedioyl-CoA + NAD(+) = 3- oxotetradecanedioyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:40211, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:77038, ChEBI:CHEBI:77041; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40212; Evidence=; Reaction=(3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoA; Xref=Rhea:RHEA:47464, ChEBI:CHEBI:71586, ChEBI:CHEBI:87701; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:47466; Evidence=; Reaction=(3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoA; Xref=Rhea:RHEA:49932, ChEBI:CHEBI:85108, ChEBI:CHEBI:131990; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:49934; Evidence=; Reaction=(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:31187, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62548, ChEBI:CHEBI:62616; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31188; Evidence=; Reaction=(3E)-decenoyl-CoA = (2E)-decenoyl-CoA; Xref=Rhea:RHEA:45752, ChEBI:CHEBI:61406, ChEBI:CHEBI:84793; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45753; Evidence=; Reaction=(3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA; Xref=Rhea:RHEA:45748, ChEBI:CHEBI:62077, ChEBI:CHEBI:85415; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45749; Evidence=; Reaction=(3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA; Xref=Rhea:RHEA:45736, ChEBI:CHEBI:62077, ChEBI:CHEBI:84790; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45737; Evidence=; Reaction=(3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O; Xref=Rhea:RHEA:31191, ChEBI:CHEBI:15377, ChEBI:CHEBI:61406, ChEBI:CHEBI:62616; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31193; Evidence=; Reaction=(3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O; Xref=Rhea:RHEA:30547, ChEBI:CHEBI:15377, ChEBI:CHEBI:62075, ChEBI:CHEBI:62077; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:30549; Evidence=; Reaction=(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:31159, ChEBI:CHEBI:15378, ChEBI:CHEBI:57349, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62613; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31160; Evidence=; Reaction=(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O; Xref=Rhea:RHEA:31163, ChEBI:CHEBI:15377, ChEBI:CHEBI:61526, ChEBI:CHEBI:62613; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31165; Evidence=; Reaction=(2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl- CoA; Xref=Rhea:RHEA:40259, ChEBI:CHEBI:15377, ChEBI:CHEBI:77075, ChEBI:CHEBI:77080; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40260; Evidence=; Reaction=(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3- oxohexadecanedioyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:40267, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:77080, ChEBI:CHEBI:77081; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40268; Evidence=; Enzyme activity enhanced by acetylation. Lipid metabolism; fatty acid beta-oxidation. Monomer. Peroxisome Acetylated, leading to enhanced enzyme activity. Acetylation is enhanced by up to 80% after treatment either with trichostin A (TCA) or with nicotinamide (NAM) with highest increase on Lys-344. Acetylation and enzyme activity increased by about 1.5% on addition of fatty acids (By similarity). Mutant mice fed a normal chow are phenotypically indistinguishable from wild-types. Mutant mice fed coconut oil rapidly lose weight and most of them die within 3 weeks. They overaccumulate dicarboxylic fatty acids, which activate all fatty acid oxidation pathways and lead to liver inflammation, fibrosis, and death. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. catalytic activity 3-hydroxyacyl-CoA dehydrogenase activity dodecenoyl-CoA delta-isomerase activity enoyl-CoA hydratase activity mitochondrion peroxisome cytosol internal protein amino acid acetylation lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation acyl-CoA metabolic process metabolic process oxidoreductase activity lyase activity isomerase activity enzyme binding oxidation-reduction process uc007yrm.1 uc007yrm.2 uc007yrm.3 uc007yrm.4 
ENSMUST00000023561.8 Senp2 ENSMUST00000023561.8 SUMO/sentrin specific peptidase 2, transcript variant 2 (from RefSeq NR_027488.1) ENSMUST00000023561.1 ENSMUST00000023561.2 ENSMUST00000023561.3 ENSMUST00000023561.4 ENSMUST00000023561.5 ENSMUST00000023561.6 ENSMUST00000023561.7 NR_027488 Q544T8 Q811R3 Q91ZX6 Q9D4Z0 SENP2_MOUSE Smt3ip2 Supr1 uc007yrw.1 uc007yrw.2 uc007yrw.3 Protease that catalyzes two essential functions in the SUMO pathway (PubMed:11489887, PubMed:20194620). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (By similarity). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:11489887, PubMed:20194620, PubMed:27637147). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (PubMed:11489887). Deconjugates SUMO2 from MTA1 (By similarity). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (PubMed:27637147). [Isoform 3]: Activates transcription. Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus (By similarity). Interacts with MTA1 (By similarity). [Isoform 1]: Nucleus, nuclear pore complex Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side Note=Shuttles between cytoplasm and nucleus. [Isoform 2]: Cytoplasm Cytoplasmic vesicle Note=Found in the cytoplasm and in cytoplasmic vesicles, together with axin. [Isoform 3]: Nucleus, PML body Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q91ZX6-1; Sequence=Displayed; Name=2; IsoId=Q91ZX6-2; Sequence=VSP_005273; Name=3; IsoId=Q91ZX6-3; Sequence=VSP_021942; Highly expressed in testis. Detected in brain, heart and thymus. In 3T3-L1 cells, expression is transiently induced during early adipocyte differentiation (PubMed:20194620). The N-terminus is necessary and sufficient for nuclear envelope targeting. Polyubiquitinated; which leads to proteasomal degradation. Belongs to the peptidase C48 family. positive regulation of protein phosphorylation nucleus nuclear pore cytoplasm cytosol proteolysis heart development peptidase activity cysteine-type peptidase activity dorsal/ventral axis specification protein transport membrane Wnt signaling pathway nuclear body PML body hydrolase activity protein desumoylation protein domain specific binding negative regulation of protein ubiquitination positive regulation of protein ubiquitination cytoplasmic vesicle protein destabilization nuclear membrane negative regulation of protein binding regulation of DNA endoreduplication negative regulation of chromatin binding negative regulation of DNA damage response, signal transduction by p53 class mediator fat cell differentiation positive regulation of transcription from RNA polymerase II promoter mRNA transport regulation of protein metabolic process trophoblast giant cell differentiation labyrinthine layer development spongiotrophoblast layer development SUMO-specific endopeptidase activity SUMO-specific isopeptidase activity negative regulation of signal transduction by p53 class mediator regulation of G1/S transition of mitotic cell cycle uc007yrw.1 uc007yrw.2 uc007yrw.3 
ENSMUST00000023562.9 Tmem41a ENSMUST00000023562.9 transmembrane protein 41a, transcript variant 1 (from RefSeq NM_025693.4) ENSMUST00000023562.1 ENSMUST00000023562.2 ENSMUST00000023562.3 ENSMUST00000023562.4 ENSMUST00000023562.5 ENSMUST00000023562.6 ENSMUST00000023562.7 ENSMUST00000023562.8 NM_025693 Q9D8U2 TM41A_MOUSE uc007yrs.1 uc007yrs.2 uc007yrs.3 uc007yrs.4 Membrane ; Multi-pass membrane protein The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain. Belongs to the TMEM41 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007yrs.1 uc007yrs.2 uc007yrs.3 uc007yrs.4 
ENSMUST00000023566.11 Tmprss15 ENSMUST00000023566.11 transmembrane protease, serine 15, transcript variant 1 (from RefSeq NM_008941.4) ENSMUST00000023566.1 ENSMUST00000023566.10 ENSMUST00000023566.2 ENSMUST00000023566.3 ENSMUST00000023566.4 ENSMUST00000023566.5 ENSMUST00000023566.6 ENSMUST00000023566.7 ENSMUST00000023566.8 ENSMUST00000023566.9 ENTK_MOUSE Entk NM_008941 P97435 Prss7 Q148Y3 uc007zsy.1 uc007zsy.2 uc007zsy.3 uc007zsy.4 This gene encodes an enzyme that proteolytically activates the pancreatic proenzyme trypsinogen, converting it into trypsin. The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (By similarity). Reaction=Activation of trypsinogen by selective cleavage of 6-Lys-|- Ile-7 bond.; EC=3.4.21.9; Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond. Membrane ; Single-pass type II membrane protein The chains are derived from a single precursor that is cleaved by a trypsin-like protease. Belongs to the peptidase S1 family. serine-type endopeptidase activity scavenger receptor activity proteolysis endocytosis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc007zsy.1 uc007zsy.2 uc007zsy.3 uc007zsy.4 
ENSMUST00000023568.14 Chodl ENSMUST00000023568.14 chondrolectin, transcript variant 1 (from RefSeq NM_139134.5) CHODL_MOUSE ENSMUST00000023568.1 ENSMUST00000023568.10 ENSMUST00000023568.11 ENSMUST00000023568.12 ENSMUST00000023568.13 ENSMUST00000023568.2 ENSMUST00000023568.3 ENSMUST00000023568.4 ENSMUST00000023568.5 ENSMUST00000023568.6 ENSMUST00000023568.7 ENSMUST00000023568.8 ENSMUST00000023568.9 NM_139134 Q3US20 Q8BVU2 Q8VI31 Q9CXM0 uc007zsw.1 uc007zsw.2 uc007zsw.3 May play a role in the development of the nervous system such as in neurite outgrowth and elongation (PubMed:24067532). May be involved in motor axon growth and guidance (By similarity). Interacts with RABGGTB (PubMed:18161010). Q9CXM0; P53612: Rabggtb; NbExp=2; IntAct=EBI-13948582, EBI-9104297; Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist. ; Name=1; Synonyms=Chodl-001; IsoId=Q9CXM0-1; Sequence=Displayed; Name=2; Synonyms=Chodl-002; IsoId=Q9CXM0-2; Sequence=VSP_058918; In adult mice preferentially expressed in skeletal muscle, testis, brain, and lung. Expressed in striated muscle (at protein level). Expressed in spinal chord. Detected in spinal chord fast motor neurons (at protein level). During gestation (7dpc to 15 dpc) its expression is up-regulated. In 15 dpc embryo is expressed in muscle cells of heterogeneous origin, including those from tongue, trunk, and tail. In newborn mice localized to limb striated muscle cells. Expressed in myoblasts undergoing myogenic differentiation during proliferation and differentiation phases (PubMed:12711387). Expressed in spinal chord motor neurons at 10.5 dpc. Detected in the plexus region of the developing limb bud at 10.5 dpc and 11.5 dpc (PubMed:20437528). Isoform 1 but not isoform 2 expression is down-regulated at postnatal day (P) 7 in spinal muscular atrophy (SMA) model motor neurons before onset of disease. Name=Functional Glycomics Gateway - Glycan Binding; Note=Chondrolectin; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_335"; protein binding cytoplasm nervous system development regulation of neuron projection development membrane integral component of membrane carbohydrate binding perinuclear region of cytoplasm positive regulation of axonogenesis hyaluronic acid binding uc007zsw.1 uc007zsw.2 uc007zsw.3 
ENSMUST00000023570.14 Btg3 ENSMUST00000023570.14 BTG anti-proliferation factor 3, transcript variant 1 (from RefSeq NM_009770.3) Btg3 ENSMUST00000023570.1 ENSMUST00000023570.10 ENSMUST00000023570.11 ENSMUST00000023570.12 ENSMUST00000023570.13 ENSMUST00000023570.2 ENSMUST00000023570.3 ENSMUST00000023570.4 ENSMUST00000023570.5 ENSMUST00000023570.6 ENSMUST00000023570.7 ENSMUST00000023570.8 ENSMUST00000023570.9 NM_009770 Q52L83 Q52L83_MOUSE uc007zsp.1 uc007zsp.2 uc007zsp.3 This gene encodes B cell translocation gene 3, a member of the BTG gene family. This family is defined by a conserved N-terminal domain, known to bind transcription factors, and a less conserved C-terminal domain. This protein is thought to have anti-proliferative properties, and may be involved in regulating the G1-S transition to suppress cell cycle progression. Mice deficient for this gene display an increased incidence of lung cancers, and many human lung cancer cells exhibit decreased levels of B cell translocation gene 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jul 2014]. Belongs to the BTG family. cytoplasm negative regulation of mitotic cell cycle uc007zsp.1 uc007zsp.2 uc007zsp.3 
ENSMUST00000023572.15 Cxadr ENSMUST00000023572.15 coxsackie virus and adenovirus receptor, transcript variant 1 (from RefSeq NM_001025192.3) CXAR_MOUSE Car ENSMUST00000023572.1 ENSMUST00000023572.10 ENSMUST00000023572.11 ENSMUST00000023572.12 ENSMUST00000023572.13 ENSMUST00000023572.14 ENSMUST00000023572.2 ENSMUST00000023572.3 ENSMUST00000023572.4 ENSMUST00000023572.5 ENSMUST00000023572.6 ENSMUST00000023572.7 ENSMUST00000023572.8 ENSMUST00000023572.9 NM_001025192 O09052 P97792 Q3ULD0 Q91W66 Q99KG0 Q9DBJ8 uc007zsn.1 uc007zsn.2 uc007zsn.3 uc007zsn.4 This gene encodes a protein that is part of the Cortical Thymocyte marker in Xenopus (CTX) subfamily within the immunoglobulin superfamily. Members of this subfamily, predominantly expressed on the surface of endothelial and epithelial cells, help establish cell polarity and provide a barrier function, regulating migration of immune cells. This protein, first identified as the receptor for adenovirus subgroup C and coxsakieviruses group B, is developmentally regulated and plays an important role in cardiac development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3- kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. Monomer. May form homodimer. Interacts with LNX, MAGI1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with MPDZ; recruits MPDZ to intercellular contact sites. Interacts with JAML (homodimeric form). P97792; P60710: Actb; NbExp=6; IntAct=EBI-7429264, EBI-353957; P97792-1; P19793: RXRA; Xeno; NbExp=2; IntAct=EBI-15903843, EBI-78598; [Isoform 1]: Cell membrane ; Single-pass type I membrane protein Basolateral cell membrane ; Single-pass type I membrane protein Cell junction, tight junction Cell junction, adherens junction Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface. [Isoform 3]: Secreted Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P97792-1; Sequence=Displayed; Name=2; IsoId=P97792-2; Sequence=VSP_014829; Name=3; IsoId=P97792-3; Sequence=VSP_014827, VSP_014828; Expressed in liver, kidney, heart, lung, and brain. In skeletal muscle is found at the neuromuscular junction. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. Expression starts in the embryonic ectoderm in the uterus on 6.5 dpc. Then it is strongly expressed in the neuroepithelium of the neural tube, the developing brain and the spinal cord from 8.5 dpc to postnatal day 7 (P7), in the cranial motor nerves from 9.5 dpc to 11.5 dpc, and in the optic nerve from 13.5 dpc to P7. Expression increases until perinatal period and decreases postnatally. Expressed in the immature neuroepithelium including progenitor cells it still occurs in a few proliferating cells of the hippocampal dentate gyrus, the subventricular zone of the lateral ventricles, and the rostral migratory stream over P21. Also expressed in heart, kidney and liver of newborn mice. The Ig-like C2-type 1 domain mediates homodimerization and interaction with JAML. The PDZ-binding motif mediates interaction with MPDZ and MAGI1. Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane. acrosomal vesicle receptor binding integrin binding protein binding extracellular region extracellular space nucleus nucleoplasm cytoplasm plasma membrane cell-cell junction adherens junction cell-cell adherens junction bicellular tight junction mitochondrion organization cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules heart development beta-catenin binding germ cell migration epithelial structure maintenance intercalated disc membrane integral component of membrane basolateral plasma membrane apicolateral plasma membrane cell junction PDZ domain binding filopodium growth cone neutrophil chemotaxis actin cytoskeleton reorganization neuromuscular junction macromolecular complex homotypic cell-cell adhesion identical protein binding neuron projection cell body membrane raft cell-cell junction organization gamma-delta T cell activation cardiac muscle fiber development cell adhesion molecule binding defense response to virus negative regulation of cardiac muscle cell proliferation positive regulation of epithelial cell proliferation involved in wound healing transepithelial transport connexin binding AV node cell to bundle of His cell communication AV node cell-bundle of His cell adhesion involved in cell communication cell adhesive protein binding involved in AV node cell-bundle of His cell communication cell-cell adhesion regulation of AV node cell action potential uc007zsn.1 uc007zsn.2 uc007zsn.3 uc007zsn.4 
ENSMUST00000023580.8 Usp25 ENSMUST00000023580.8 ubiquitin specific peptidase 25 (from RefSeq NM_013918.2) ENSMUST00000023580.1 ENSMUST00000023580.2 ENSMUST00000023580.3 ENSMUST00000023580.4 ENSMUST00000023580.5 ENSMUST00000023580.6 ENSMUST00000023580.7 NM_013918 P57080 Q80ZT9 UBP25_MOUSE uc007zsb.1 uc007zsb.2 uc007zsb.3 Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains (By similarity). The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Homodimer or oligomer (By similarity). Interacts with ACTA1 (via its C-terminus); the interaction occurs for all isoforms but is strongest for isoform USP25m in muscle differentiating cells. Interacts (isoform USP25m only) with MYBPC1; the interaction prevents proteasomal degradation of MYBPC1. Interacts (isoform USP25m only) with FLNC (via filament repeats 17-18, 20-21 and 24). Interacts with GAPDH. Interacts with SUMO3; the interaction sumoylates efficiently USP25. Interacts with SUMO2; the interaction sumoylates efficiently USP25. Interacts with SUMO1; the interaction only weakly sumoylates USP25. Interacts with SYK; phosphorylates USP25 and regulates USP25 intracellular levels (By similarity). Cytoplasm Nucleus Note=The longer muscle-specific isoform (USP25m) Some transient punctuate nuclear location in myotubes during myocyte development. Event=Alternative splicing; Named isoforms=1; Comment=A longer muscle-specific isoform, USP25m, also exists.; Name=1; IsoId=P57080-1; Sequence=Displayed; Highly expressed in testis especially in primary and secondary spematocytes and in immature spermatids. Also found in brain, skeletal muscle, liver and heart. At 13.5 dpc and 16.5 dpc, expression in the brain correlates with the proliferate ventricular zone and post-mitotic neurons of the intermediate zone, particularly in the forebrain. More marked expression at 16.5 dpc in the telencephalic septum and in the pallium. In myocytes, expressed throughout differentiation of myotubes. Induced by type I interferons (IFNA and IFNB1) produced in response to lipopolysaccharide (LPS) and viral infection (HIV-1 and SeV viruses) (at protein level). Acetylated. Sumoylation impairs binding to and hydrolysis of ubiquitin chains. Sumoylated preferentially with SUMO2 or SUMO3. Desumoylated by SENP1. Regulated by ubiquitination on the same residue (By similarity). Preferentially monoubiquitinated but can also be polyubiquitinated. Autodeubiquitinated. Ubiquitination activates the enzymatic activity either by preventing sumoylation or by allowing novel interactions (By similarity). Phosphorylation in the C-terminal by SYK regulates USP25 cellular levels. Belongs to the peptidase C19 family. proteasome complex cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus cytoplasm endoplasmic reticulum cytosol proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity ubiquitin protein ligase binding thiol-dependent ubiquitinyl hydrolase activity ATPase binding protein K63-linked deubiquitination protein K48-linked deubiquitination negative regulation of ERAD pathway uc007zsb.1 uc007zsb.2 uc007zsb.3 
ENSMUST00000023590.9 Hrg ENSMUST00000023590.9 histidine-rich glycoprotein (from RefSeq NM_053176.2) A0A0R4J039 A0A0R4J039_MOUSE ENSMUST00000023590.1 ENSMUST00000023590.2 ENSMUST00000023590.3 ENSMUST00000023590.4 ENSMUST00000023590.5 ENSMUST00000023590.6 ENSMUST00000023590.7 ENSMUST00000023590.8 Hrg NM_053176 uc007ysw.1 uc007ysw.2 uc007ysw.3 uc007ysw.4 positive regulation of immune response to tumor cell cysteine-type endopeptidase inhibitor activity receptor binding extracellular region negative regulation of cell adhesion heparin binding zinc ion binding negative regulation of cell proliferation cell surface regulation of gene expression negative regulation of lamellipodium assembly negative regulation of endopeptidase activity negative regulation of angiogenesis immunoglobulin binding heme binding platelet activation regulation of blood coagulation negative regulation of cell growth regulation of actin cytoskeleton organization negative regulation of cell adhesion mediated by integrin positive regulation of apoptotic process regulation of protein complex assembly heparan sulfate proteoglycan binding metal ion binding regulation of peptidyl-tyrosine phosphorylation defense response to fungus cytolysis in other organism positive regulation of focal adhesion assembly negative regulation of vascular endothelial growth factor signaling pathway positive regulation of blood vessel remodeling negative regulation of endothelial cell chemotaxis uc007ysw.1 uc007ysw.2 uc007ysw.3 uc007ysw.4 
ENSMUST00000023593.6 Adipoq ENSMUST00000023593.6 adiponectin, C1Q and collagen domain containing (from RefSeq NM_009605.5) ADIPO_MOUSE Acdc Acrp30 Apm1 ENSMUST00000023593.1 ENSMUST00000023593.2 ENSMUST00000023593.3 ENSMUST00000023593.4 ENSMUST00000023593.5 NM_009605 Q60994 Q62400 Q6GTX4 Q9DC68 uc007ytk.1 uc007ytk.2 uc007ytk.3 Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. Polymerization and secretion of adiponectin is inhibited by succination of cysteine residues by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues. Homomultimer (PubMed:23209641). Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW) (PubMed:23209641). The HMW-complex assembly is also modulated by the degree of lysine hydroxylation and glycosylation (PubMed:23209641). LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9 via the C1q domain (heterotrimeric complex) (PubMed:18787108). Q60994; Q60994: Adipoq; NbExp=17; IntAct=EBI-7264589, EBI-7264589; Q60994; Q9DCM2: Gstk1; NbExp=3; IntAct=EBI-7264589, EBI-8369416; Q60994; Q9Y2Q3: GSTK1; Xeno; NbExp=2; IntAct=EBI-7264589, EBI-1053767; Secreted Synthesized exclusively by adipocytes and secreted into plasma. During hormone-induced adipose differentiation and activated by insulin. HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the lysine residues within the collagen-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes. O-glycosylated. Not N-glycosylated (By similarity) O-linked glycans on hydroxylysine residues consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups (By similarity). O-linked glycosylation in the N-terminal is disialylated with the structure Neu5Acalpha2->8Neu5Acalpha2->3Gal. Sialylated by alpha 2,8-sialyltransferase III. Succination of Cys-39 by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits polymerization and secretion of adiponectin. Adiponectin is a major target for succination in both adipocytes and adipose tissue of diabetic mice. It was proposed that succination of proteins is a biomarker of mitochondrial stress and accumulation of Krebs cycle intermediates in adipose tissue in diabetes and that succination of adiponectin may contribute to the decrease in plasma adiponectin in diabetes. HMW-complex blood contents are higher in females than in males, are increased in males by castration and decreased again upon subsequent testosterone treatment, which blocks HMW-complex secretion. response to hypoxia positive regulation of protein phosphorylation receptor binding hormone activity extracellular matrix structural constituent protein binding extracellular region collagen trimer extracellular space endoplasmic reticulum glucose metabolic process fatty acid beta-oxidation signal transduction response to nutrient circadian rhythm response to bacterium response to sucrose response to glucose positive regulation of signal transduction cell surface negative regulation of platelet-derived growth factor receptor signaling pathway positive regulation of protein kinase A signaling negative regulation of macrophage derived foam cell differentiation negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of cholesterol efflux regulation of glucose metabolic process response to activity fatty acid oxidation negative regulation of cell migration negative regulation of granulocyte differentiation response to nutrient levels negative regulation of protein autophosphorylation positive regulation of cellular protein metabolic process negative regulation of tumor necrosis factor production positive regulation of interleukin-8 production cellular response to insulin stimulus macromolecular complex positive regulation of myeloid cell apoptotic process sialic acid binding negative regulation of heterotypic cell-cell adhesion low-density lipoprotein particle clearance response to tumor necrosis factor cellular response to drug response to drug glucose homeostasis identical protein binding protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity response to ethanol negative regulation of fat cell differentiation negative regulation of macrophage differentiation negative regulation of low-density lipoprotein particle receptor biosynthetic process negative regulation of gluconeogenesis negative regulation of blood pressure positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of glucose import negative regulation of hormone secretion perinuclear region of cytoplasm negative regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation negative regulation of phagocytosis negative regulation of synaptic transmission brown fat cell differentiation protein homooligomerization response to glucocorticoid negative regulation of ERK1 and ERK2 cascade response to linoleic acid detection of oxidative stress cellular response to cAMP positive regulation of monocyte chemotactic protein-1 production cellular response to epinephrine stimulus cell periphery protein localization to plasma membrane negative regulation of intracellular protein transport negative regulation of receptor binding negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration negative regulation of DNA biosynthetic process positive regulation of glycogen (starch) synthase activity positive regulation of metanephric glomerular visceral epithelial cell development positive regulation of cAMP-dependent protein kinase activity positive regulation of renal albumin absorption negative regulation of platelet-derived growth factor receptor-alpha signaling pathway negative regulation of metanephric mesenchymal cell migration uc007ytk.1 uc007ytk.2 uc007ytk.3 
ENSMUST00000023598.15 Rfc4 ENSMUST00000023598.15 replication factor C (activator 1) 4 (from RefSeq NM_145480.1) ENSMUST00000023598.1 ENSMUST00000023598.10 ENSMUST00000023598.11 ENSMUST00000023598.12 ENSMUST00000023598.13 ENSMUST00000023598.14 ENSMUST00000023598.2 ENSMUST00000023598.3 ENSMUST00000023598.4 ENSMUST00000023598.5 ENSMUST00000023598.6 ENSMUST00000023598.7 ENSMUST00000023598.8 ENSMUST00000023598.9 NM_145480 Q99J62 RFC4_MOUSE uc007yth.1 uc007yth.2 uc007yth.3 The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity). Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA (By similarity). Interacts with CNTD1; this interaction facilitates crossover formation (PubMed:32640224). Nucleus Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP. Belongs to the activator 1 small subunits family. nucleotide binding DNA binding DNA clamp loader activity ATP binding nucleus nucleoplasm DNA replication factor C complex DNA replication DNA-dependent DNA replication single-stranded DNA-dependent ATP-dependent DNA helicase activity enzyme binding Ctf18 RFC-like complex Elg1 RFC-like complex DNA duplex unwinding positive regulation of DNA-directed DNA polymerase activity uc007yth.1 uc007yth.2 uc007yth.3 
ENSMUST00000023599.13 Eif4a2 ENSMUST00000023599.13 eukaryotic translation initiation factor 4A2, transcript variant 1 (from RefSeq NM_013506.3) ENSMUST00000023599.1 ENSMUST00000023599.10 ENSMUST00000023599.11 ENSMUST00000023599.12 ENSMUST00000023599.2 ENSMUST00000023599.3 ENSMUST00000023599.4 ENSMUST00000023599.5 ENSMUST00000023599.6 ENSMUST00000023599.7 ENSMUST00000023599.8 ENSMUST00000023599.9 Eif4a2 NM_013506 Q52KC1 Q52KC1_MOUSE uc007ytd.1 uc007ytd.2 uc007ytd.3 uc007ytd.4 uc007ytd.5 ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. RNA helicase. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence= The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. Belongs to the DEAD box helicase family. eIF4A subfamily. nucleotide binding nucleic acid binding translation initiation factor activity helicase activity ATP binding translational initiation hydrolase activity uc007ytd.1 uc007ytd.2 uc007ytd.3 uc007ytd.4 uc007ytd.5 
ENSMUST00000023600.8 Robo1 ENSMUST00000023600.8 roundabout guidance receptor 1, transcript variant 2 (from RefSeq NM_019413.3) ENSMUST00000023600.1 ENSMUST00000023600.2 ENSMUST00000023600.3 ENSMUST00000023600.4 ENSMUST00000023600.5 ENSMUST00000023600.6 ENSMUST00000023600.7 G5E843 G5E843_MOUSE NM_019413 Robo1 uc007zrb.1 uc007zrb.2 uc007zrb.3 cell migration involved in sprouting angiogenesis cytoplasm plasma membrane activation of cysteine-type endopeptidase activity involved in apoptotic process homophilic cell adhesion via plasma membrane adhesion molecules axon guidance axon guidance receptor activity cell surface axon midline choice point recognition chemorepulsion involved in postnatal olfactory bulb interneuron migration LRR domain binding negative regulation of cell migration negative regulation of mammary gland epithelial cell proliferation positive regulation of Rho protein signal transduction Roundabout signaling pathway identical protein binding positive regulation of MAP kinase activity positive regulation of axonogenesis negative regulation of negative chemotaxis negative regulation of chemokine-mediated signaling pathway positive regulation of vascular endothelial growth factor signaling pathway uc007zrb.1 uc007zrb.2 uc007zrb.3 
ENSMUST00000023601.14 St6gal1 ENSMUST00000023601.14 beta galactoside alpha 2,6 sialyltransferase 1, transcript variant 1 (from RefSeq NM_145933.4) ENSMUST00000023601.1 ENSMUST00000023601.10 ENSMUST00000023601.11 ENSMUST00000023601.12 ENSMUST00000023601.13 ENSMUST00000023601.2 ENSMUST00000023601.3 ENSMUST00000023601.4 ENSMUST00000023601.5 ENSMUST00000023601.6 ENSMUST00000023601.7 ENSMUST00000023601.8 ENSMUST00000023601.9 NM_145933 Q64685 Q8K1L1 SIAT1_MOUSE Siat1 uc007yto.1 uc007yto.2 uc007yto.3 uc007yto.4 This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on chromosome 15. [provided by RefSeq, Nov 2011]. Transfers sialic acid from CMP-sialic acid to galactose- containing acceptor substrates. Reaction=a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N- acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+); Xref=Rhea:RHEA:52104, ChEBI:CHEBI:15378, ChEBI:CHEBI:28034, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:136398; EC=2.4.3.1; Evidence=; Protein modification; protein glycosylation. Monomer and homodimer. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid. The soluble form derives from the membrane form by proteolytic processing. N-glycosylated. Belongs to the glycosyltransferase 29 family. Name=Functional Glycomics Gateway - GTase; Note=ST6Gal I; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_648"; Golgi trans cisterna Golgi membrane beta-galactoside alpha-2,6-sialyltransferase activity extracellular region endoplasmic reticulum Golgi apparatus Golgi medial cisterna N-acetylneuraminate metabolic process protein glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein N-linked glycosylation via asparagine Golgi cisterna membrane positive regulation of mononuclear cell proliferation protein homodimerization activity negative regulation of chemotaxis sialylation regulation of substrate adhesion-dependent cell spreading protein sialylation negative regulation of macrophage apoptotic process uc007yto.1 uc007yto.2 uc007yto.3 uc007yto.4 
ENSMUST00000023602.6 Prl2a1 ENSMUST00000023602.6 prolactin family 2, subfamily a, member 1 (from RefSeq NM_019991.1) ENSMUST00000023602.1 ENSMUST00000023602.2 ENSMUST00000023602.3 ENSMUST00000023602.4 ENSMUST00000023602.5 NM_019991 PR2A1_MOUSE Prlpm Q9JHK0 Q9JI05 uc007pye.1 uc007pye.2 uc007pye.3 Secreted Expressed specifically in the placenta. Expression restricted to the junctional zone of the chorioallantoic placenta. Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pye.1 uc007pye.2 uc007pye.3 
ENSMUST00000023608.14 Atp5pf ENSMUST00000023608.14 ATP synthase peripheral stalk subunit F6, transcript variant 20 (from RefSeq NR_184384.1) ATP5J_MOUSE Atp5j Atp5pf ENSMUST00000023608.1 ENSMUST00000023608.10 ENSMUST00000023608.11 ENSMUST00000023608.12 ENSMUST00000023608.13 ENSMUST00000023608.2 ENSMUST00000023608.3 ENSMUST00000023608.4 ENSMUST00000023608.5 ENSMUST00000023608.6 ENSMUST00000023608.7 ENSMUST00000023608.8 ENSMUST00000023608.9 NR_184384 P97450 uc007zti.1 uc007zti.2 uc007zti.3 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes. F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). Mitochondrion. Mitochondrion inner membrane. Belongs to the eukaryotic ATPase subunit F6 family. mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) extracellular space mitochondrion mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex ion transport cell surface positive regulation of heart rate response to muscle activity hydrogen ion transmembrane transporter activity ATP synthesis coupled proton transport membrane ATPase activity negative regulation of prostaglandin secretion macromolecular complex binding proton-transporting ATP synthase complex, coupling factor F(o) positive regulation of blood pressure ATP metabolic process negative regulation of arachidonic acid secretion uc007zti.1 uc007zti.2 uc007zti.3 
ENSMUST00000023610.15 Adamts1 ENSMUST00000023610.15 ADAM metallopeptidase with thrombospondin type 1 motif 1 (from RefSeq NM_009621.5) ATS1_MOUSE E9QMN9 ENSMUST00000023610.1 ENSMUST00000023610.10 ENSMUST00000023610.11 ENSMUST00000023610.12 ENSMUST00000023610.13 ENSMUST00000023610.14 ENSMUST00000023610.2 ENSMUST00000023610.3 ENSMUST00000023610.4 ENSMUST00000023610.5 ENSMUST00000023610.6 ENSMUST00000023610.7 ENSMUST00000023610.8 ENSMUST00000023610.9 NM_009621 O54768 P97857 uc012aho.1 uc012aho.2 uc012aho.3 uc012aho.4 This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050834.1, AK156830.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cleaves aggrecan, a cartilage proteoglycan, at the '1691- Glu-|-Leu-1692' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover. Has angiogenic inhibitor activity (By similarity). Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix. In embryonic skeletal muscle, significantly increased levels between 13.5 dpc and 15.5 dpc with maximal expression observed at 15.5 dpc (PubMed:23233679). Decreased levels in postnatal skeletal muscle (PubMed:23233679). In myoblasts, up-regulated soon after induction of myoblast differentiation (PubMed:23233679). Induced in vitro in colon adenocarcinoma cells by interleukin-1, or in vivo in kidney and heart by lipopolysaccharide. Also induced by LH stimulation in granulosa cells of preovulatory follicles. The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2- G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3- glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). Sequence=BAA11088.1; Type=Frameshift; Evidence=; Sequence=BAA24501.1; Type=Erroneous initiation; Evidence=; ovulation from ovarian follicle kidney development metalloendopeptidase activity protein binding extracellular region basement membrane proteolysis heparin binding peptidase activity metallopeptidase activity zinc ion binding positive regulation of neuron projection development negative regulation of angiogenesis hydrolase activity extracellular matrix cytoplasmic vesicle metal ion binding heart trabecula formation positive regulation of G1/S transition of mitotic cell cycle positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration uc012aho.1 uc012aho.2 uc012aho.3 uc012aho.4 
ENSMUST00000023611.7 Adamts5 ENSMUST00000023611.7 ADAM metallopeptidase with thrombospondin type 1 motif 5 (from RefSeq NM_011782.2) ATS5_MOUSE B2RRX9 ENSMUST00000023611.1 ENSMUST00000023611.2 ENSMUST00000023611.3 ENSMUST00000023611.4 ENSMUST00000023611.5 ENSMUST00000023611.6 NM_011782 Q9R001 uc007ztw.1 uc007ztw.2 uc007ztw.3 This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. Mice lacking the encoded protein are protected from surgery-induced osteoarthritis and antigen-induced arthritis. [provided by RefSeq, May 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.213468.1, AF140673.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that shows proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (PubMed:23233679). Participates in the development of brown adipose tissue and browning of white adipose tissue (PubMed:28702327). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection (PubMed:27855162). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix Expressed in skeletal muscle. Expressed specifically in the peri-implantation period in embryo and trophoblast and at low or undetectable level thereafter (PubMed:10464288). In embryonic skeletal muscle, levels significantly increase between 13.5 dpc and 15.5 dpc with maximal expression observed at 15.5 dpc (PubMed:23233679). Decreased levels in postnatal skeletal muscle (PubMed:23233679). In myoblasts, up-regulated soon after induction of myoblast differentiation (PubMed:23233679). The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by furin and PCSK7 outside of the cell. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2- G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3- glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). Mice are viable and fertile (PubMed:15800625). Significantly increased mass of brown adipose tissue (PubMed:28702327). Delayed virus clearance and compromised T cell migration during viral infection (PubMed:27855162). No effect on VCAN cleavage in embryonic skeletal muscle, potentially as a result of participation by other proteinases, but absence of VCAN cleavage and greater number of centrally located nuclei in postnatal skeletal muscle (PubMed:23233679). metalloendopeptidase activity extracellular region extracellular space proteolysis heparin binding peptidase activity metallopeptidase activity zinc ion binding hydrolase activity defense response to bacterium tooth eruption metal ion binding extracellular matrix binding uc007ztw.1 uc007ztw.2 uc007ztw.3 
ENSMUST00000023612.17 Ets2 ENSMUST00000023612.17 E26 avian leukemia oncogene 2, 3' domain (from RefSeq NM_011809.3) ENSMUST00000023612.1 ENSMUST00000023612.10 ENSMUST00000023612.11 ENSMUST00000023612.12 ENSMUST00000023612.13 ENSMUST00000023612.14 ENSMUST00000023612.15 ENSMUST00000023612.16 ENSMUST00000023612.2 ENSMUST00000023612.3 ENSMUST00000023612.4 ENSMUST00000023612.5 ENSMUST00000023612.6 ENSMUST00000023612.7 ENSMUST00000023612.8 ENSMUST00000023612.9 Ets2 NM_011809 Q3UP99 Q3UP99_MOUSE uc008ace.1 uc008ace.2 uc008ace.3 uc008ace.4 Transcription factor. Nucleus Belongs to the ETS family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol plasma membrane regulation of transcription, DNA-templated protein domain specific binding glucocorticoid receptor binding sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc008ace.1 uc008ace.2 uc008ace.3 uc008ace.4 
ENSMUST00000023615.7 Vps26c ENSMUST00000023615.7 VPS26 endosomal protein sorting factor C (from RefSeq NM_007834.3) Dcra Dscr3 Dscra ENSMUST00000023615.1 ENSMUST00000023615.2 ENSMUST00000023615.3 ENSMUST00000023615.4 ENSMUST00000023615.5 ENSMUST00000023615.6 NM_007834 O35075 Q542V5 VP26C_MOUSE Vps26c uc008abe.1 uc008abe.2 uc008abe.3 uc008abe.4 Acts as a component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. Component of the heterotrimeric retriever complex formed by VPS26C, VPS29 and VPS35L. Interacts with SNX17; the interaction is direct and associates SNX17 with the retriever complex. Interacts with SNX31; the interaction is direct. Endosome Belongs to the VPS26 family. endosome intracellular protein transport endocytic recycling retrograde transport, endosome to plasma membrane uc008abe.1 uc008abe.2 uc008abe.3 uc008abe.4 
ENSMUST00000023616.11 Slc15a2 ENSMUST00000023616.11 solute carrier family 15 (H+/peptide transporter), member 2, transcript variant 1 (from RefSeq NM_021301.4) E9QMN8 ENSMUST00000023616.1 ENSMUST00000023616.10 ENSMUST00000023616.2 ENSMUST00000023616.3 ENSMUST00000023616.4 ENSMUST00000023616.5 ENSMUST00000023616.6 ENSMUST00000023616.7 ENSMUST00000023616.8 ENSMUST00000023616.9 NM_021301 Q9JM03 Q9JM03_MOUSE Slc15a2 uc007zcv.1 uc007zcv.2 uc007zcv.3 uc007zcv.4 Reaction=2 H(+)(out) + L-alanyl-L-alanine(out) = 2 H(+)(in) + L-alanyl- L-alanine(in); Xref=Rhea:RHEA:76183, ChEBI:CHEBI:15378, ChEBI:CHEBI:195181; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76184; Evidence=; Reaction=3 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = 3 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in); Xref=Rhea:RHEA:76375, ChEBI:CHEBI:15378, ChEBI:CHEBI:155830; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76376; Evidence=; Reaction=a dipeptide(out) + 2 H(+)(out) = a dipeptide(in) + 2 H(+)(in); Xref=Rhea:RHEA:76179, ChEBI:CHEBI:15378, ChEBI:CHEBI:90799; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76180; Evidence=; Reaction=an L-amino acid tripeptide(out) + 2 H(+)(out) = an L-amino acid tripeptide(in) + 2 H(+)(in); Xref=Rhea:RHEA:76187, ChEBI:CHEBI:15378, ChEBI:CHEBI:155837; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76188; Evidence=; Reaction=carnosine(out) + 2 H(+)(out) = carnosine(in) + 2 H(+)(in); Xref=Rhea:RHEA:76191, ChEBI:CHEBI:15378, ChEBI:CHEBI:57485; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76192; Evidence=; Reaction=glycyl-L-glutamate(out) + 3 H(+)(out) = glycyl-L-glutamate(in) + 3 H(+)(in); Xref=Rhea:RHEA:76175, ChEBI:CHEBI:15378, ChEBI:CHEBI:73784; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76176; Evidence=; Reaction=glycyl-L-leucine(out) + 2 H(+)(out) = glycyl-L-leucine + 2 H(+)(in); Xref=Rhea:RHEA:76167, ChEBI:CHEBI:15378, ChEBI:CHEBI:143163; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76168; Evidence=; Reaction=glycyl-L-lysine(out) + 2 H(+)(out) = glycyl-L-lysine(in) + 2 H(+)(in); Xref=Rhea:RHEA:76171, ChEBI:CHEBI:15378, ChEBI:CHEBI:194323; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76172; Evidence=; Interacts (via extracellular domain region) with trypsin. Apical cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein Membrane ; Multi- pass membrane protein Belongs to the major facilitator superfamily. Proton- dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. oligopeptide transport membrane integral component of membrane transmembrane transporter activity oligopeptide transmembrane transport oligopeptide transmembrane transporter activity transmembrane transport uc007zcv.1 uc007zcv.2 uc007zcv.3 uc007zcv.4 
ENSMUST00000023619.8 Stfa2 ENSMUST00000023619.8 stefin A2 (from RefSeq NM_001082545.1) B2RQN4 CYT2_MOUSE E9QMN6 ENSMUST00000023619.1 ENSMUST00000023619.2 ENSMUST00000023619.3 ENSMUST00000023619.4 ENSMUST00000023619.5 ENSMUST00000023619.6 ENSMUST00000023619.7 NM_001082545 P35174 Stf-2 Stf2 uc007zcn.1 uc007zcn.2 uc007zcn.3 This is an intracellular thiol proteinase inhibitor. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P35174-1; Sequence=Displayed; Name=2; IsoId=P35174-2; Sequence=VSP_044325; Belongs to the cystatin family. endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity cytoplasm cytosol negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc007zcn.1 uc007zcn.2 uc007zcn.3 
ENSMUST00000023629.9 Pros1 ENSMUST00000023629.9 protein S (alpha) (from RefSeq NM_011173.3) ENSMUST00000023629.1 ENSMUST00000023629.2 ENSMUST00000023629.3 ENSMUST00000023629.4 ENSMUST00000023629.5 ENSMUST00000023629.6 ENSMUST00000023629.7 ENSMUST00000023629.8 NM_011173 Pros1 Q3TR66 Q3TR66_MOUSE uc007zpx.1 uc007zpx.2 uc007zpx.3 uc007zpx.4 uc007zpx.5 This gene encodes a vitamin K-dependent protein with key roles in multiple biological processes including coagulation, apoptosis and vasculogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein which is secreted into the plasma. Mice lacking the encoded protein die in utero from a fulminant coagulopathy and associated hemorrhages. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.151161.1, AK145501.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding extracellular region extracellular space negative regulation of blood coagulation uc007zpx.1 uc007zpx.2 uc007zpx.3 uc007zpx.4 uc007zpx.5 
ENSMUST00000023630.16 Psmg1 ENSMUST00000023630.16 proteasome (prosome, macropain) assembly chaperone 1 (from RefSeq NM_019537.3) Dscr2 ENSMUST00000023630.1 ENSMUST00000023630.10 ENSMUST00000023630.11 ENSMUST00000023630.12 ENSMUST00000023630.13 ENSMUST00000023630.14 ENSMUST00000023630.15 ENSMUST00000023630.2 ENSMUST00000023630.3 ENSMUST00000023630.4 ENSMUST00000023630.5 ENSMUST00000023630.6 ENSMUST00000023630.7 ENSMUST00000023630.8 ENSMUST00000023630.9 NM_019537 PSMG1_MOUSE Psmg1 Q8BU12 Q9JK23 uc008ach.1 uc008ach.2 uc008ach.3 Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity). Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits (By similarity). Cytoplasm Endoplasmic reticulum Highly expressed in testis with moderate expression in brain, liver and kidney and low levels in heart, skeletal muscle and pancreas. Expressed at a fairly constant level throughout embryonic development. Degraded by the proteasome upon completion of 20S proteasome maturation. Belongs to the PSMG1 family. nucleoplasm cytoplasm endoplasmic reticulum Golgi apparatus cytosol cerebellar granule cell precursor proliferation proteasome assembly proteasome binding proteasome core complex assembly uc008ach.1 uc008ach.2 uc008ach.3 
ENSMUST00000023652.16 Grik1 ENSMUST00000023652.16 glutamate receptor, ionotropic, kainate 1, transcript variant 2 (from RefSeq NM_010348.4) ENSMUST00000023652.1 ENSMUST00000023652.10 ENSMUST00000023652.11 ENSMUST00000023652.12 ENSMUST00000023652.13 ENSMUST00000023652.14 ENSMUST00000023652.15 ENSMUST00000023652.2 ENSMUST00000023652.3 ENSMUST00000023652.4 ENSMUST00000023652.5 ENSMUST00000023652.6 ENSMUST00000023652.7 ENSMUST00000023652.8 ENSMUST00000023652.9 F6Z3M4 F6Z3M4_MOUSE Grik1 NM_010348 uc007zus.1 uc007zus.2 uc007zus.3 uc007zus.4 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]. Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane Membrane ; Multi-pass membrane protein Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. ionotropic glutamate receptor activity ion channel activity plasma membrane ion transport ligand-gated ion channel activity membrane integral component of membrane cell junction ion transmembrane transport ionotropic glutamate receptor signaling pathway signaling receptor activity synapse postsynaptic membrane uc007zus.1 uc007zus.2 uc007zus.3 uc007zus.4 
ENSMUST00000023660.9 Ripply3 ENSMUST00000023660.9 ripply transcriptional repressor 3 (from RefSeq NM_133229.2) B8JK62 DSCR6_MOUSE Dscr6 ENSMUST00000023660.1 ENSMUST00000023660.2 ENSMUST00000023660.3 ENSMUST00000023660.4 ENSMUST00000023660.5 ENSMUST00000023660.6 ENSMUST00000023660.7 ENSMUST00000023660.8 NM_133229 Q8BYB3 Q924S9 uc008aaj.1 uc008aaj.2 uc008aaj.3 uc008aaj.4 Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives. Interacts with TBX1. Nucleus Expressed in the endoderm and ectoderm cells of the caudal pharyngeal region at 8.5 dpc. The Ripply homology domain and the WRPW motif are both necessary for its transcriptional corepressor activity on the transcription activator TBX1. The WRPW motif is required for binding to tle/groucho proteins. Mice are viable, fertile and morphologically normal. Show abnormal development of pharyngeal derivatives, including ectopic formation of the thymus and the parathyroid gland, as well as cardiovascular malformation. Belongs to the ripply family. negative regulation of transcription from RNA polymerase II promoter protein binding nucleus multicellular organism development heart development negative regulation of cell proliferation embryonic pattern specification pharyngeal system development uc008aaj.1 uc008aaj.2 uc008aaj.3 uc008aaj.4 
ENSMUST00000023666.11 Chaf1b ENSMUST00000023666.11 chromatin assembly factor 1, subunit B, transcript variant 1 (from RefSeq NM_028083.5) CAF1B_MOUSE Chaf1b ENSMUST00000023666.1 ENSMUST00000023666.10 ENSMUST00000023666.2 ENSMUST00000023666.3 ENSMUST00000023666.4 ENSMUST00000023666.5 ENSMUST00000023666.6 ENSMUST00000023666.7 ENSMUST00000023666.8 ENSMUST00000023666.9 NM_028083 Q9D0N7 uc008aac.1 uc008aac.2 uc008aac.3 Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer (By similarity). Subunit of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. CHAF1A binds directly to CHAF1B (By similarity). Interacts with histones H3.1, H3.2 and H3.1t (By similarity). Nucleus Cytoplasm Note=DNA replication foci. Cytoplasmic in M phase. Belongs to the WD repeat HIR1 family. nuclear chromatin protein binding nucleus nucleoplasm DNA replication DNA repair nucleosome assembly DNA replication-dependent nucleosome assembly cellular response to DNA damage stimulus cell cycle chromatin assembly macromolecular complex CAF-1 complex histone binding uc008aac.1 uc008aac.2 uc008aac.3 
ENSMUST00000023670.4 Clic6 ENSMUST00000023670.4 chloride intracellular channel 6 (from RefSeq NM_172469.3) CLIC6_MOUSE ENSMUST00000023670.1 ENSMUST00000023670.2 ENSMUST00000023670.3 NM_172469 Q8BHB9 uc007zzg.1 uc007zzg.2 uc007zzg.3 May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). Interacts with dopamine receptors DRD2, DRD3 and DRD4. Cytoplasm Cell membrane ; Single-pass membrane protein Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as a chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity). Phosphorylated. Belongs to the chloride channel CLIC family. voltage-gated ion channel activity chloride channel activity cytoplasm plasma membrane ion transport chloride transport protein C-terminus binding membrane integral component of membrane D2 dopamine receptor binding D3 dopamine receptor binding D4 dopamine receptor binding ion transmembrane transport chloride channel complex regulation of ion transmembrane transport protein homodimerization activity chloride transmembrane transport uc007zzg.1 uc007zzg.2 uc007zzg.3 
ENSMUST00000023672.10 Rcan1 ENSMUST00000023672.10 regulator of calcineurin 1, transcript variant 2 (from RefSeq NM_019466.4) Dscr1 ENSMUST00000023672.1 ENSMUST00000023672.2 ENSMUST00000023672.3 ENSMUST00000023672.4 ENSMUST00000023672.5 ENSMUST00000023672.6 ENSMUST00000023672.7 ENSMUST00000023672.8 ENSMUST00000023672.9 NM_019466 Q7TNY3 Q91WQ4 Q9JHG6 Q9JK50 Q9JK51 Q9JKK2 Q9JKK3 RCAN1_MOUSE uc007zzd.1 uc007zzd.2 uc007zzd.3 uc007zzd.4 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (PubMed:11231093). Interacts with RAF1 and PPP3R1 (By similarity). Interacts with PPP3CA (PubMed:12809556). Q9JHG6; Q61214: Dyrk1a; NbExp=2; IntAct=EBI-644061, EBI-80344; Q9JHG6; P35922: Fmr1; NbExp=3; IntAct=EBI-644061, EBI-645094; Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=A; Synonyms=1, CALP1-L ; IsoId=Q9JHG6-1; Sequence=Displayed; Name=B; Synonyms=4; IsoId=Q9JHG6-2; Sequence=VSP_001317; Name=C; IsoId=Q9JHG6-3; Sequence=VSP_001318; Name=E; Synonyms=CALP1-S ; IsoId=Q9JHG6-4; Sequence=VSP_059568; Highly expressed in heart and skeletal muscle. Also expressed in all other tissues. Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life. Belongs to the RCAN family. Sequence=AAF91461.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; response to ischemia nucleic acid binding protein binding nucleus cytoplasm response to oxidative stress short-term memory calcium-dependent protein serine/threonine phosphatase regulator activity calcium-mediated signaling locomotion involved in locomotory behavior calcineurin-NFAT signaling cascade identical protein binding regulation of phosphoprotein phosphatase activity skeletal muscle fiber development regulation of calcineurin-NFAT signaling cascade negative regulation of calcineurin-NFAT signaling cascade uc007zzd.1 uc007zzd.2 uc007zzd.3 uc007zzd.4 
ENSMUST00000023673.14 Runx1 ENSMUST00000023673.14 runt related transcription factor 1, transcript variant 2 (from RefSeq NM_001111022.2) ENSMUST00000023673.1 ENSMUST00000023673.10 ENSMUST00000023673.11 ENSMUST00000023673.12 ENSMUST00000023673.13 ENSMUST00000023673.2 ENSMUST00000023673.3 ENSMUST00000023673.4 ENSMUST00000023673.5 ENSMUST00000023673.6 ENSMUST00000023673.7 ENSMUST00000023673.8 ENSMUST00000023673.9 NM_001111022 Q3UM65 Q3UM65_MOUSE Runx1 uc007zzj.1 uc007zzj.2 uc007zzj.3 uc007zzj.4 uc007zzj.5 Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. Nucleus RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding ATP binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated hemopoiesis positive regulation of granulocyte differentiation positive regulation of interleukin-2 production intracellular membrane-bounded organelle transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc007zzj.1 uc007zzj.2 uc007zzj.3 uc007zzj.4 uc007zzj.5 
ENSMUST00000023677.10 Atp5po ENSMUST00000023677.10 ATP synthase peripheral stalk subunit OSCP (from RefSeq NM_138597.2) ATPO_MOUSE Atp5o Atp5po D12Wsu28e ENSMUST00000023677.1 ENSMUST00000023677.2 ENSMUST00000023677.3 ENSMUST00000023677.4 ENSMUST00000023677.5 ENSMUST00000023677.6 ENSMUST00000023677.7 ENSMUST00000023677.8 ENSMUST00000023677.9 NM_138597 Q9DB20 uc007zys.1 uc007zys.2 uc007zys.3 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT- ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). Mitochondrion Mitochondrion inner membrane Acetylation of Lys-70 and Lys-158 is observed in liver mitochondria from fasted mice but not from fed mice. Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3 (By similarity). Belongs to the ATPase delta chain family. mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) mitochondrion mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex plasma membrane ATP biosynthetic process ion transport drug binding cell surface ATP synthesis coupled proton transport membrane ATPase activity mitochondrial ATP synthesis coupled proton transport myelin sheath macromolecular complex binding ATP metabolic process proton-transporting ATP synthase activity, rotational mechanism cellular response to cAMP cellular response to cytokine stimulus estradiol binding uc007zys.1 uc007zys.2 uc007zys.3 
ENSMUST00000023682.12 Donson ENSMUST00000023682.12 downstream neighbor of SON (from RefSeq NM_021720.1) DONS_MOUSE ENSMUST00000023682.1 ENSMUST00000023682.10 ENSMUST00000023682.11 ENSMUST00000023682.2 ENSMUST00000023682.3 ENSMUST00000023682.4 ENSMUST00000023682.5 ENSMUST00000023682.6 ENSMUST00000023682.7 ENSMUST00000023682.8 ENSMUST00000023682.9 NM_021720 ORF60 Q80V93 Q8BV55 Q9QXP4 uc007zyc.1 uc007zyc.2 uc007zyc.3 Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. Component of the replisome complex composed of at least MCM2, MCM7, PCNA and TICRR; interaction at least with PCNA occurs during DNA replication. Nucleus Note=Localizes at DNA replication sites. At 14.5 dpc, widely expressed, including in neocortex, cerebellum, lung, liver, hindlimb, intestine, as well as forelimb, kidney and spinal cord vertebrae. Early embryonic lethality. Heterozygous mice show no overt phenotype. Belongs to the DONSON family. DNA damage checkpoint molecular_function nucleus replication fork DNA replication mitotic G2 DNA damage checkpoint multicellular organism development replisome nuclear DNA replication replication fork protection uc007zyc.1 uc007zyc.2 uc007zyc.3 
ENSMUST00000023684.14 Gart ENSMUST00000023684.14 Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. (from UniProt Q64737) AK146355 ENSMUST00000023684.1 ENSMUST00000023684.10 ENSMUST00000023684.11 ENSMUST00000023684.12 ENSMUST00000023684.13 ENSMUST00000023684.2 ENSMUST00000023684.3 ENSMUST00000023684.4 ENSMUST00000023684.5 ENSMUST00000023684.6 ENSMUST00000023684.7 ENSMUST00000023684.8 ENSMUST00000023684.9 PUR2_MOUSE Q3TGI3 Q64737 Q6NS48 uc007zxu.1 uc007zxu.2 uc007zxu.3 uc007zxu.4 Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. Reaction=5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate; Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58681, ChEBI:CHEBI:143788, ChEBI:CHEBI:456216; EC=6.3.4.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17454; Evidence=; Reaction=2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate; Xref=Rhea:RHEA:23032, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:137981, ChEBI:CHEBI:147287, ChEBI:CHEBI:456216; EC=6.3.3.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23033; Evidence=; Reaction=(6R)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D- ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)- formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide; Xref=Rhea:RHEA:15053, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453, ChEBI:CHEBI:143788, ChEBI:CHEBI:147286, ChEBI:CHEBI:195366; EC=2.1.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15054; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 magnesium or manganese ion per subunit. ; Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide: step 2/2. Purine metabolism; IMP biosynthesis via de novo pathway; N(1)- (5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1- diphosphate: step 2/2. Purine metabolism; IMP biosynthesis via de novo pathway; N(2)- formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D- ribosyl)glycinamide (10-formyl THF route): step 1/1. Homodimer. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q64737-1; Sequence=Displayed; Name=Short; IsoId=Q64737-2; Sequence=VSP_005518; Detected in liver, kidney and brain. The N-terminal ATP-grasp domain carries the phosphoribosylamine--glycine ligase activity. The central AIRS domain carries the phosphoribosylformylglycinamidine cyclo-ligase activity. The C-terminal GART domain carries the phosphoribosylglycinamide formyltransferase activity. In the N-terminal section; belongs to the GARS family. In the central section; belongs to the AIR synthase family. In the C-terminal section; belongs to the GART family. nucleotide binding brainstem development catalytic activity phosphoribosylamine-glycine ligase activity phosphoribosylformylglycinamidine cyclo-ligase activity phosphoribosylglycinamide formyltransferase activity ATP binding cytosol purine nucleotide biosynthetic process 'de novo' IMP biosynthetic process glycine metabolic process metabolic process biosynthetic process purine nucleobase biosynthetic process ribonucleoside monophosphate biosynthetic process response to organic substance response to inorganic substance transferase activity hydroxymethyl-, formyl- and related transferase activity ligase activity cerebellum development cerebral cortex development tetrahydrofolate biosynthetic process metal ion binding uc007zxu.1 uc007zxu.2 uc007zxu.3 uc007zxu.4 
ENSMUST00000023686.15 Tmem50b ENSMUST00000023686.15 transmembrane protein 50B, transcript variant 9 (from RefSeq NR_185058.1) ENSMUST00000023686.1 ENSMUST00000023686.10 ENSMUST00000023686.11 ENSMUST00000023686.12 ENSMUST00000023686.13 ENSMUST00000023686.14 ENSMUST00000023686.2 ENSMUST00000023686.3 ENSMUST00000023686.4 ENSMUST00000023686.5 ENSMUST00000023686.6 ENSMUST00000023686.7 ENSMUST00000023686.8 ENSMUST00000023686.9 NR_185058 Q3UZ98 Q8N7M9 Q9D1X9 TM50B_MOUSE uc007zxr.1 uc007zxr.2 uc007zxr.3 May form homotrimers or homodimers. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Expressed in brain, heart and testis (at protein level). In the cerebellum, has particularly strong expression in Bergmann astroglial cells (at protein level). Detected in cortical plate, trigeminal ganglion, dorsal root ganglia and the spinal cord at embryonic stage 14.5 dpc. Widely expressed in brain at postnatal day 7 including cortex, olfactory bulb, hippocampus and cerebellum. Expressed throughout layers II-VI of the cortex. In the olfactory bulb, has strongest expression in glomerular and mitral cell layers. In hippocampus, localizes to CA1, CA2, CA3 and dentate gyrus regions. In cerebellum, mainly expressed in the internal granule cell layer and the Purkinje cell layer. Belongs to the UPF0220 family. Golgi membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus membrane integral component of membrane late endosome to vacuole transport via multivesicular body sorting pathway uc007zxr.1 uc007zxr.2 uc007zxr.3 
ENSMUST00000023687.9 Ifngr2 ENSMUST00000023687.9 interferon gamma receptor 2 (from RefSeq NM_008338.4) ENSMUST00000023687.1 ENSMUST00000023687.2 ENSMUST00000023687.3 ENSMUST00000023687.4 ENSMUST00000023687.5 ENSMUST00000023687.6 ENSMUST00000023687.7 ENSMUST00000023687.8 Ifngr2 NM_008338 Q63953 Q63953_MOUSE ifngr2 uc007zxq.1 uc007zxq.2 uc007zxq.3 microglial cell activation cytokine receptor activity plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway defense response to virus positive regulation of NMDA glutamate receptor activity uc007zxq.1 uc007zxq.2 uc007zxq.3 
ENSMUST00000023689.11 Ifnar1 ENSMUST00000023689.11 interferon (alpha and beta) receptor 1 (from RefSeq NM_010508.2) ENSMUST00000023689.1 ENSMUST00000023689.10 ENSMUST00000023689.2 ENSMUST00000023689.3 ENSMUST00000023689.4 ENSMUST00000023689.5 ENSMUST00000023689.6 ENSMUST00000023689.7 ENSMUST00000023689.8 ENSMUST00000023689.9 INAR1_MOUSE Ifar Ifnar NM_010508 P33896 Q80UJ3 uc007zxn.1 uc007zxn.2 uc007zxn.3 uc007zxn.4 uc007zxn.5 Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:14532120, PubMed:1533935, PubMed:24075985). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (By similarity). Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (PubMed:23872679). Heterodimer with IFNAR2; forming the receptor for type I interferon (By similarity). Interacts with TYK2 (By similarity). Interacts with STAT1 and STAT2 (By similarity). Interacts (serine- phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:14532120). 3Interacts with SHMT2; this promotes interaction with ABRAXAS2 and the BRISC complex (By similarity). Interacts with TRIM10; this interaction prevents association between IFNAR1 and TYK2 (By similarity). Cell membrane ingle-pass type I membrane protein Late endosome Lysosome Note=Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes. Ubiquitinated (PubMed:14532120). This leads to its internalization and lysosomal degradation. The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex; this prevents receptor internalization and degradation. Probable ubiquitination sites have been identified in human, but are poorly conserved across species. Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination (PubMed:14532120). Mice are protected from the lethal septic effects of intraperitoneal LPS administration observed in wild-type mice (PubMed:23872679). Double knockout with TREX1 does not show a visible phenotype (PubMed:18724932). The interferon signaling pathway is not identical between species. Thus, the interaction with STAT1 and STAT2 may not be conserved in mouse; in human it requires phosphorylation at 'Tyr-466', but the mouse protein has a Phe at the equivalent position. Likewise, cysteine palmitoylation is required for the activation of STAT1 and STAT2 in human, but the Cys is not conserved in mouse. Belongs to the type II cytokine receptor family. cytokine receptor activity interferon receptor activity type I interferon receptor activity lysosome endosome late endosome plasma membrane integral component of plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway type I interferon binding response to lipopolysaccharide positive regulation of interferon-beta production positive regulation of interferon-gamma production cellular response to interferon-alpha T cell activation type I interferon biosynthetic process positive regulation of transcription, DNA-templated positive regulation of interleukin-1 beta secretion regulation of peptidyl-tyrosine phosphorylation defense response to virus type I interferon signaling pathway uc007zxn.1 uc007zxn.2 uc007zxn.3 uc007zxn.4 uc007zxn.5 
ENSMUST00000023691.12 Il10rb ENSMUST00000023691.12 interleukin 10 receptor, beta, transcript variant 10 (from RefSeq NR_175908.1) ENSMUST00000023691.1 ENSMUST00000023691.10 ENSMUST00000023691.11 ENSMUST00000023691.2 ENSMUST00000023691.3 ENSMUST00000023691.4 ENSMUST00000023691.5 ENSMUST00000023691.6 ENSMUST00000023691.7 ENSMUST00000023691.8 ENSMUST00000023691.9 Il10r2 Il10rb NR_175908 Q8VHM7 Q8VHM7_MOUSE uc007zxk.1 uc007zxk.2 uc007zxk.3 membrane integral component of membrane uc007zxk.1 uc007zxk.2 uc007zxk.3 
ENSMUST00000023693.14 Ifnar2 ENSMUST00000023693.14 interferon (alpha and beta) receptor 2, transcript variant 1 (from RefSeq NM_010509.2) ENSMUST00000023693.1 ENSMUST00000023693.10 ENSMUST00000023693.11 ENSMUST00000023693.12 ENSMUST00000023693.13 ENSMUST00000023693.2 ENSMUST00000023693.3 ENSMUST00000023693.4 ENSMUST00000023693.5 ENSMUST00000023693.6 ENSMUST00000023693.7 ENSMUST00000023693.8 ENSMUST00000023693.9 INAR2_MOUSE NM_010509 O35238 O35663 O35664 O35983 Q923Z5 uc007zxh.1 uc007zxh.2 uc007zxh.3 uc007zxh.4 Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. [Isoform 2]: May be potent inhibitors of type I IFN receptor activity. [Isoform 3]: May be potent inhibitors of type I IFN receptor activity. Heterodimer with IFNAR1; forming the receptor for type I interferon. Interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1. Interacts with USP18; indirectly via STAT2, it negatively regulates the assembly of the ternary interferon-IFNAR1- IFNAR2 complex and therefore type I interferon signaling. [Isoform 1]: Cell membrane ; Single-pass type I membrane protein [Isoform 2]: Secreted [Isoform 3]: Secreted Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=IFNaR2c; IsoId=O35664-1; Sequence=Displayed; Name=2; Synonyms=IFNaR2b; IsoId=O35664-2; Sequence=VSP_050345, VSP_050347; Name=3; Synonyms=IFNaR2a; IsoId=O35664-3; Sequence=VSP_050346, VSP_050348; Widely expressed. Detected in liver, testis, kidney, salivary gland, thymus, brain, lung and placenta. Isoform 1, isoform 2 and isoform 3 are expressed in brain. Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-335 or Tyr-510 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types (By similarity). Belongs to the type II cytokine receptor family. cytokine receptor activity type I interferon receptor activity extracellular region extracellular space plasma membrane integral component of plasma membrane regulation of transcription from RNA polymerase II promoter cell proliferation membrane integral component of membrane cytokine-mediated signaling pathway protein kinase binding type I interferon binding response to interferon-alpha response to interferon-beta defense response to virus type I interferon signaling pathway uc007zxh.1 uc007zxh.2 uc007zxh.3 uc007zxh.4 
ENSMUST00000023694.11 Cfap298 ENSMUST00000023694.11 cilia and flagella associate protien 298 (from RefSeq NM_026502.2) CF298_MOUSE Cfap298 ENSMUST00000023694.1 ENSMUST00000023694.10 ENSMUST00000023694.2 ENSMUST00000023694.3 ENSMUST00000023694.4 ENSMUST00000023694.5 ENSMUST00000023694.6 ENSMUST00000023694.7 ENSMUST00000023694.8 ENSMUST00000023694.9 NM_026502 Q8BL95 Q8VCL7 uc007zwt.1 uc007zwt.2 uc007zwt.3 uc007zwt.4 Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity. Interacts with ZMYND10. Cytoplasm Cytoplasm, cytoskeleton, cilium basal body Note=Partially colocalized with SASS6 in cytoplasmic puncta, suggesting a centrosomal localization. Belongs to the CFAP298 family. regulation of cilium movement molecular_function cytoplasm cytosol cytoskeleton cilium cell projection cilium assembly uc007zwt.1 uc007zwt.2 uc007zwt.3 uc007zwt.4 
ENSMUST00000023707.11 Sod1 ENSMUST00000023707.11 superoxide dismutase 1, soluble (from RefSeq NM_011434.2) ENSMUST00000023707.1 ENSMUST00000023707.10 ENSMUST00000023707.2 ENSMUST00000023707.3 ENSMUST00000023707.4 ENSMUST00000023707.5 ENSMUST00000023707.6 ENSMUST00000023707.7 ENSMUST00000023707.8 ENSMUST00000023707.9 NM_011434 P08228 SODC_MOUSE Sod1 uc007zvz.1 uc007zvz.2 uc007zvz.3 Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18421; EC=1.15.1.1; Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Note=Binds 1 copper ion per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Homodimer; non-disulfide-linked (PubMed:20727846). Heterodimer with SOD1. The heterodimer CCS:SOD1 interacts with SLC31A1; this heterotrimer is Cu(1+)-mediated and its maintenance is regulated through SOD1 activation (By similarity). P08228; P99029: Prdx5; NbExp=2; IntAct=EBI-1635090, EBI-2735704; P08228; P63001: Rac1; NbExp=4; IntAct=EBI-1635090, EBI-413646; P08228; O55042: Snca; NbExp=2; IntAct=EBI-1635090, EBI-2310271; Cytoplasm. Nucleus Palmitoylation helps nuclear targeting and decreases catalytic activity. Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity. 40% reduction in hepatic GPX1 activity. Belongs to the Cu-Zn superoxide dismutase family. activation of MAPK activity response to reactive oxygen species response to superoxide ovarian follicle development positive regulation of cytokine production retina homeostasis response to amphetamine myeloid cell homeostasis superoxide dismutase activity copper ion binding protein binding extracellular region extracellular space nucleus nucleoplasm cytoplasm mitochondrion mitochondrial intermembrane space lysosome peroxisome cytosol plasma membrane glutathione metabolic process superoxide metabolic process cellular iron ion homeostasis response to oxidative stress spermatogenesis embryo implantation aging cell aging sensory perception of sound locomotory behavior anterograde axonal transport retrograde axonal transport regulation of blood pressure zinc ion binding response to heat response to organic substance antioxidant activity oxidoreductase activity transmission of nerve impulse removal of superoxide radicals enzyme binding secretory granule protein phosphatase 2B binding dense core granule cytoplasmic vesicle response to nutrient levels peripheral nervous system myelin maintenance dendrite cytoplasm positive regulation of superoxide anion generation macromolecular complex response to carbon monoxide cellular response to oxidative stress cellular response to potassium ion regulation of multicellular organism growth response to drug response to hydrogen peroxide superoxide anion generation identical protein binding neuron projection neuronal cell body negative regulation of apoptotic process positive regulation of catalytic activity regulation of GTPase activity myelin sheath negative regulation of neuron apoptotic process response to ethanol negative regulation of cholesterol biosynthetic process regulation of protein kinase activity response to antibiotic response to copper ion muscle cell cellular homeostasis metal ion binding Rac GTPase binding response to axon injury hydrogen peroxide biosynthetic process negative regulation of inflammatory response positive regulation of phagocytosis chaperone binding regulation of mitochondrial membrane potential oxidation-reduction process heart contraction neurofilament cytoskeleton organization relaxation of vascular smooth muscle auditory receptor cell stereocilium organization cellular response to cadmium ion cellular response to ATP reactive oxygen species metabolic process response to antipsychotic drug positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway axon cytoplasm uc007zvz.1 uc007zvz.2 uc007zvz.3 
ENSMUST00000023709.7 Krt5 ENSMUST00000023709.7 keratin 5 (from RefSeq NM_027011.3) ENSMUST00000023709.1 ENSMUST00000023709.2 ENSMUST00000023709.3 ENSMUST00000023709.4 ENSMUST00000023709.5 ENSMUST00000023709.6 K2C5_MOUSE Krt2-5 Krt5 NM_027011 Q920F2 Q922U2 uc007xtw.1 uc007xtw.2 uc007xtw.3 Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (PubMed:11408584). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (PubMed:19267394). Heterodimer of a type I and a type II keratin. Heterodimer with type I keratin KRT25 leading to the formation of keratin intermediate filament (KIF) network (By similarity). Forms a heterodimer (via 2B domains) with KRT14 (via 2B domains) (PubMed:24940650). Interacts with PLEC isoform 1C, when in a heterodimer with KRT14 (PubMed:24940650). Interacts with TCHP (By similarity). Interacts with EPPK1 (PubMed:18285451). Interacts with AMELX (PubMed:12657653). Interacts with PKP1 (via N-terminus) and PKP2 (By similarity). Cytoplasm Expressed in the corneal epithelium (at protein level) (PubMed:26758872, PubMed:11408584). Expressed in the epidermis of the ear (at protein level) (PubMed:24751727). Expressed in the basal and spinous layers of the skin at birth (at protein level) (PubMed:11408584). Expressed in basal layer cells of the stratified squamous epithelia at 15.5 dpc (PubMed:29518391). Expressed in the skin after birth (PubMed:29518391). Expressed in ameloblasts at the cervical and apical mid-regions of mandibular molars at birth, abundance at the apical mid-region significantly increases at P1, and is maintained throughout enamel development until P9 when ameloblasts start losing their integrity (PubMed:12657653). Expressed in ameloblasts at the incisal region of mandibular molars at P3 (PubMed:12657653). Expressed at the Tomes' processes of ameloblasts at the incisal region at P5 (PubMed:12657653). Expression at the incisal region decreased at P7 and P9 (PubMed:12657653). Weakly expressed in the spinous and granular layers of the tongue at P20 (PubMed:32758484). Phosphorylated by CDK1, AURKB and Rho-kinase, phosphorylation is regulated by the cell cycle (PubMed:29518391). Thr-24 phosphorylation, mediated by CDK1, peaks during prometaphase or metaphase cells with phosphorylated filamentous structures evident throughout the cytoplasm during early mitosis (PubMed:29518391). CDK1 phosphorylates Thr-24 in mitotic cells at the site of injury (PubMed:29518391). O-glycosylated. Paws are frequently denuded and epidermis loses contact with the dermis following the mechanical stress of birth, mice die within 1 hour of birth (PubMed:11408584). Tongue cytolysis is evident following birth even before the first milk uptake (PubMed:11408584). Complete loss of keratin filaments in the basal layer, leading to cleavage of the epidermis in the subnuclear cytoplasm just superficial to the hemidesmosomes (PubMed:11408584). Increase in Krt6 expression in the spinous and lower granular layers as well as weakly in basal layer of the blistering roof of cytolyzing cells at birth (PubMed:11408584). Decrease in Krt14 expression in the skin following birth (PubMed:11408584). Increase in Langerhans cells in the epidermis (PubMed:19267394). Decrease in Ctnnd1/p120 localization to the plasma membrane and adherens junctions of basal keratinocytes (PubMed:19267394). Increase in the cytokines Cxcl16, Ccl2, Ccl19 and Ccl20 in the epidermis at birth (PubMed:19267394). There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. protein binding cytoplasm mitochondrion intermediate filament plasma membrane keratin filament scaffold protein binding uc007xtw.1 uc007xtw.2 uc007xtw.3 
ENSMUST00000023710.6 Krt71 ENSMUST00000023710.6 keratin 71 (from RefSeq NM_019956.1) A0JLW9 ENSMUST00000023710.1 ENSMUST00000023710.2 ENSMUST00000023710.3 ENSMUST00000023710.4 ENSMUST00000023710.5 K2C71_MOUSE K6irs1 Kb34 Krt2-6g Krt6g NM_019956 Q7TPF3 Q9D0X6 Q9R0H5 uc007xtx.1 uc007xtx.2 uc007xtx.3 Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. Heterodimer of a type I and a type II keratin. Associates with KRT16 and/or KRT17. Cytoplasm, cytoskeleton Specifically expressed in the inner root sheath (IRS) of the hair follicle. Present in Henle and the Huxley layers of the IRS, while expression in the cuticle is unsure (at protein level). Expressed exclusively in the inner root sheath (IRS) of anagen hair follicles, where expression is predominantly in the hair cone during anagen III and in the Huxley and Henle layers of the inner root sheath during anagen VI. Mice exhibit defects in hair structure and progressive alopecia. Missense mutations cause milder phenotypes such as caracul, characterized by rough and greasy fur, and wavy hair that is pointed in different directions. There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively). Belongs to the intermediate filament family. cytoplasm cytoskeleton intermediate filament hair follicle morphogenesis keratin filament intermediate filament organization uc007xtx.1 uc007xtx.2 uc007xtx.3 
ENSMUST00000023712.8 Krt2 ENSMUST00000023712.8 keratin 2 (from RefSeq NM_010668.2) ENSMUST00000023712.1 ENSMUST00000023712.2 ENSMUST00000023712.3 ENSMUST00000023712.4 ENSMUST00000023712.5 ENSMUST00000023712.6 ENSMUST00000023712.7 K22E_MOUSE K2e Krt2 Krt2-17 Krt2a NM_010668 Q0VBW1 Q3TTY5 Q61869 uc007xub.1 uc007xub.2 Probably contributes to terminal cornification (By similarity). Associated with keratinocyte activation, proliferation and keratinization (By similarity). Required for maintenance of corneocytes and keratin filaments in suprabasal keratinocytes in the epidermis of the ear, potentially via moderation of expression and localization of keratins and their partner proteins (PubMed:24751727). Plays a role in the establishment of the epidermal barrier on plantar skin (PubMed:26603179). Heterotetramer of two type I and two type II keratins. Associates with KRT10. Cytoplasm Expressed predominantly in the suprabasal layers of the plantar epidermis outside of the footpads (at protein level) (PubMed:26603179). Expressed in the suprabasal layers of the interfollicular epidermis of the ear, in the interscale regions distant from the hair follicles in the tail, and in the soles of the footpads (at protein level) (PubMed:24751727). Expressed mainly in the middle spinous and granular cells of the epidermis of adult tail, nipple and footsole skin. Also found in ear. Induction occurs during the first 2 weeks after birth, being first observed in the epidermis of tail then the footpad and later in the ear. Note=Defects in Krt2 are a cause of ichthyosis bullosa of siemens (IBS). IBS is a rare autosomal dominant disorder displaying a type of epidermolytic hyperkeratosis characterized by extensive blistering from birth. Hyperkeratoses and shedding of the outer layers of the epidermis (molting) are observed in later weeks. Mice are viable and display no differences in size and body weight (PubMed:24751727, PubMed:26603179). Scaly skin and increased pigmentation on ears and hyperkeratotic calluses on the soles and toe pads within 6 weeks of birth (PubMed:24751727, PubMed:26603179). Prominent acanthosis, orthokeratotic hyperkeratosis in the epidermis of the ear and to a lesser extent in the epidermis of the tail and the palm skin caused by an increase in cell proliferation and thicker granular layer (PubMed:24751727). Keratinocyte differentiation is disorganized, large coalescent granules are accumulated, and cytolysis is evidence in the ear skin (PubMed:24751727). Increase in defective corneocytes and an increase in transepidermal water loss in ear skin (PubMed:24751727). Suprabasal keratinocytes contain distinct spongy clumps of Krt10 filaments (PubMed:24751727). Increase in Tslp and Il18 expression, and abundance of T-cells and mast cells in ear skin (PubMed:24751727). Increase in expression of Krt1, Krt10, Krt16, Flg and Loricrin in the ear epidermis (PubMed:24751727). Krt1, Krt5, Krt10, Krt16, Flg and Loricrin all show disordered localization within the ear epidermis (PubMed:24751727). Krt10 specifically show aggregation within the cytoplasm in epidermal cells of the ear (PubMed:24751727). Show no epidermal aberrations of the footpads (PubMed:26603179). Double knockout mice of KRT2 and KRT10 are viable and display no differences in size and body weight (PubMed:26603179). Show a more severe plantar epidermis phenotype as in single KRT2 knockout mice (PubMed:26603179). There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. cornified envelope keratinocyte development intermediate filament cytoskeletal protein binding epidermis development peptide cross-linking structural constituent of epidermis keratinization keratinocyte activation keratinocyte proliferation keratin filament intermediate filament organization positive regulation of epidermis development keratinocyte migration uc007xub.1 uc007xub.2 
ENSMUST00000023713.10 Krt82 ENSMUST00000023713.10 keratin 82 (from RefSeq NM_053249.3) ENSMUST00000023713.1 ENSMUST00000023713.2 ENSMUST00000023713.3 ENSMUST00000023713.4 ENSMUST00000023713.5 ENSMUST00000023713.6 ENSMUST00000023713.7 ENSMUST00000023713.8 ENSMUST00000023713.9 KRT82_MOUSE Krt2-20 Krthb2 NM_053249 Q32MV2 Q99M74 uc007xtn.1 uc007xtn.2 uc007xtn.3 uc007xtn.4 uc007xtn.5 uc007xtn.6 Heterotetramer of two type I and two type II keratins. There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). Belongs to the intermediate filament family. intermediate filament biological_process keratin filament uc007xtn.1 uc007xtn.2 uc007xtn.3 uc007xtn.4 uc007xtn.5 uc007xtn.6 
ENSMUST00000023714.5 Krt90 ENSMUST00000023714.5 keratin 90 (from RefSeq NM_177717.4) 4732456N10Rik E9Q1Z0 E9Q1Z0_MOUSE ENSMUST00000023714.1 ENSMUST00000023714.2 ENSMUST00000023714.3 ENSMUST00000023714.4 Krt90 NM_177717 uc007xto.1 uc007xto.2 Belongs to the intermediate filament family. molecular_function cellular_component intermediate filament biological_process keratin filament uc007xto.1 uc007xto.2 
ENSMUST00000023718.9 Krt83 ENSMUST00000023718.9 keratin 83 (from RefSeq NM_001201323.1) 5430421N21Rik E9Q1Y9 E9Q1Y9_MOUSE ENSMUST00000023718.1 ENSMUST00000023718.2 ENSMUST00000023718.3 ENSMUST00000023718.4 ENSMUST00000023718.5 ENSMUST00000023718.6 ENSMUST00000023718.7 ENSMUST00000023718.8 Krt83 NM_001201323 uc007xtj.1 uc007xtj.2 uc007xtj.3 Belongs to the intermediate filament family. molecular_function intermediate filament aging hair cycle keratin filament uc007xtj.1 uc007xtj.2 uc007xtj.3 
ENSMUST00000023720.8 Krt84 ENSMUST00000023720.8 keratin 84 (from RefSeq NM_008474.2) E9QMQ6 ENSMUST00000023720.1 ENSMUST00000023720.2 ENSMUST00000023720.3 ENSMUST00000023720.4 ENSMUST00000023720.5 ENSMUST00000023720.6 ENSMUST00000023720.7 KRT84_MOUSE Krt2-16 Krthb4 NM_008474 Q1RME6 Q61862 Q99M73 uc007xtm.1 uc007xtm.2 uc007xtm.3 Heterotetramer of two type I and two type II keratins. In skin, only expressed in the suprabasal cells of tail scale epidermis. Suprabasally expressed in stratified squamous epithelia and also in the posterior unit of the complex filiform papillae of tongue. Expressed in rare anatomical sites in which an orthokeratinized stratum corneum would be too soft and a hard keratinized structure would be too rigid to meet the functional requirement of the respective epithelia. mRNA synthesis is suppressed during retinoic acid-mediated orthokeratotic conversion of tail scale epidermis. There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). Belongs to the intermediate filament family. intermediate filament structural constituent of epidermis keratin filament intermediate filament cytoskeleton regulation of keratinocyte differentiation uc007xtm.1 uc007xtm.2 uc007xtm.3 
ENSMUST00000023726.5 Lalba ENSMUST00000023726.5 lactalbumin, alpha (from RefSeq NM_010679.1) ENSMUST00000023726.1 ENSMUST00000023726.2 ENSMUST00000023726.3 ENSMUST00000023726.4 LALBA_MOUSE NM_010679 P29752 uc007xmo.1 uc007xmo.2 uc007xmo.3 Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N- acetylglucosamine of the oligosaccharide chains in glycoproteins. Lactose synthase (LS) is heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA). P29752; P08037: B4GALT1; Xeno; NbExp=10; IntAct=EBI-1031454, EBI-1031436; Secreted. Mammary gland specific. Secreted in milk. Belongs to the glycosyl hydrolase 22 family. lactose synthase activity calcium ion binding protein binding extracellular region lactose biosynthetic process metal ion binding defense response to Gram-negative bacterium defense response to Gram-positive bacterium uc007xmo.1 uc007xmo.2 uc007xmo.3 
ENSMUST00000023728.8 Spmip11 ENSMUST00000023728.8 sperm microtubule inner protein 11 (from RefSeq NM_001201322.1) 4930415O20Rik ENSMUST00000023728.1 ENSMUST00000023728.2 ENSMUST00000023728.3 ENSMUST00000023728.4 ENSMUST00000023728.5 ENSMUST00000023728.6 ENSMUST00000023728.7 NM_001201322 Q8CDT5 Q8CDT5_MOUSE Spmip11 Tex49 uc007xmy.1 uc007xmy.2 uc007xmy.3 uc007xmy.4 molecular_function cellular_component biological_process uc007xmy.1 uc007xmy.2 uc007xmy.3 uc007xmy.4 
ENSMUST00000023732.12 Wnt10b ENSMUST00000023732.12 wingless-type MMTV integration site family, member 10B (from RefSeq NM_011718.2) ENSMUST00000023732.1 ENSMUST00000023732.10 ENSMUST00000023732.11 ENSMUST00000023732.2 ENSMUST00000023732.3 ENSMUST00000023732.4 ENSMUST00000023732.5 ENSMUST00000023732.6 ENSMUST00000023732.7 ENSMUST00000023732.8 ENSMUST00000023732.9 NM_011718 P48614 P70702 WN10B_MOUSE Wnt-10b Wnt10 Wnt12 uc007xnu.1 uc007xnu.2 uc007xnu.3 uc007xnu.4 Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin. Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids. Secreted, extracellular space, extracellular matrix Secreted Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P48614-1; Sequence=Displayed; Name=Short; IsoId=P48614-2; Sequence=VSP_006796; Expressed in embryos and in the mammary gland of non-pregnant mice. Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. Belongs to the Wnt family. G2/M transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter chondrocyte differentiation receptor binding frizzled binding extracellular region extracellular space regulation of transcription from RNA polymerase II promoter lipid metabolic process cell cycle arrest signal transduction smoothened signaling pathway cell-cell signaling multicellular organism development positive regulation of cell proliferation animal organ morphogenesis positive regulation of G2/M transition of mitotic cell cycle myoblast differentiation involved in skeletal muscle regeneration Wnt signaling pathway neuron differentiation positive regulation of bone mineralization positive regulation of epithelial cell differentiation regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of apoptotic process skeletal muscle tissue regeneration cell fate commitment regulation of fat cell differentiation negative regulation of fat cell differentiation positive regulation of osteoblast differentiation positive regulation of ossification positive regulation of RNA polymerase II transcriptional preinitiation complex assembly positive regulation of transcription from RNA polymerase II promoter regulation of skeletal muscle tissue development skeletal muscle fiber development negative regulation of epithelial cell proliferation protein stabilization sensory perception of taste positive regulation of sequence-specific DNA binding transcription factor activity regulation of protein metabolic process positive regulation of anagen canonical Wnt signaling pathway bone trabecula formation fungiform papilla development cellular response to organic substance cellular response to cAMP cellular response to parathyroid hormone stimulus cellular response to organic cyclic compound hematopoietic stem cell proliferation positive regulation of canonical Wnt signaling pathway uc007xnu.1 uc007xnu.2 uc007xnu.3 uc007xnu.4 
ENSMUST00000023734.8 Wnt1 ENSMUST00000023734.8 wingless-type MMTV integration site family, member 1 (from RefSeq NM_021279.4) ENSMUST00000023734.1 ENSMUST00000023734.2 ENSMUST00000023734.3 ENSMUST00000023734.4 ENSMUST00000023734.5 ENSMUST00000023734.6 ENSMUST00000023734.7 NM_021279 Q3UR96 Q3UR96_MOUSE Wnt1 uc007xnx.1 uc007xnx.2 uc007xnx.3 Ligand for members of the frizzled family of seven transmembrane receptors. Secreted, extracellular space, extracellular matrix Belongs to the Wnt family. receptor binding extracellular region cytoplasm multicellular organism development positive regulation of cell proliferation response to wounding positive regulation of lamellipodium assembly negative regulation of cell-substrate adhesion Wnt signaling pathway negative regulation of cell-cell adhesion negative regulation of BMP signaling pathway animal organ regeneration signal transduction in response to DNA damage negative regulation of apoptotic process positive regulation of insulin-like growth factor receptor signaling pathway transcription regulatory region DNA binding positive regulation of Notch signaling pathway positive regulation of transcription, DNA-templated receptor agonist activity positive regulation of fibroblast proliferation canonical Wnt signaling pathway bone development positive regulation of dermatome development hepatocyte differentiation cellular response to peptide hormone stimulus negative regulation of cell aging uc007xnx.1 uc007xnx.2 uc007xnx.3 
ENSMUST00000023736.10 Lmbr1l ENSMUST00000023736.10 limb region 1 like, transcript variant 1 (from RefSeq NM_029098.4) D15Ertd735e ENSMUST00000023736.1 ENSMUST00000023736.2 ENSMUST00000023736.3 ENSMUST00000023736.4 ENSMUST00000023736.5 ENSMUST00000023736.6 ENSMUST00000023736.7 ENSMUST00000023736.8 ENSMUST00000023736.9 Kiaa1174 LMBRL_MOUSE NM_029098 Q3TD82 Q69ZP7 Q9D1E5 uc007xoi.1 uc007xoi.2 uc007xoi.3 Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (PubMed:31073040). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (PubMed:31073040). Acts as a LCN1 receptor and can mediate its endocytosis (By similarity). Dimer (By similarity). Can also form higher oligomers (By similarity). Interacts with LCN1; this interaction mediates the endocytosis of LCN1 (By similarity). Interacts with UBAC2, FAF2, VCP, AMFR, ZNRF3, CTNNB1, LRP6, GSK3B, FZD6, DVL2 and RNF43 (PubMed:31073040). Interacts with GSK3A (By similarity). Interaction with LGB and SCGB1A1 is controversial (By similarity). Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D1E5-1; Sequence=Displayed; Name=2; IsoId=Q9D1E5-2; Sequence=VSP_016897; Highly expressed in the bone marrow, thymus, spleen and lymphocytes. Mice exhibit severely impaired development of all lymphoid lineages, compromised antibody responses to immunization, reduced cytotoxic T-cell killing activity and natural killer (NK) cell function, and resistance to cytomegalovirus infection (PubMed:31073040). T-cells are predisposed to apoptosis and die in response to antigen-specific or homeostatic expansion signals (PubMed:31073040). Impaired differentiation of hematopoietic stem cells into the lymphoid primed multipotent progenitor (LMPP) and common lymphoid progenitor populations that give rise to T-cells, B-cells, and NK cells (PubMed:31073040). Belongs to the LIMR family. Sequence=BAD32399.1; Type=Erroneous initiation; Evidence=; transmembrane signaling receptor activity plasma membrane integral component of plasma membrane endocytosis receptor-mediated endocytosis signal transduction membrane integral component of membrane uc007xoi.1 uc007xoi.2 uc007xoi.3 
ENSMUST00000023737.6 Dhh ENSMUST00000023737.6 desert hedgehog (from RefSeq NM_007857.5) DHH_MOUSE Dhh ENSMUST00000023737.1 ENSMUST00000023737.2 ENSMUST00000023737.3 ENSMUST00000023737.4 ENSMUST00000023737.5 NM_007857 Q61488 uc007xoh.1 uc007xoh.2 uc007xoh.3 uc007xoh.4 uc007xoh.5 [Desert hedgehog protein]: The C-terminal part of the desert hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (DhhN and DhhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated DhhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Functions in cell-cell mediated juxtacrine signaling (By similarity). Promotes endothelium integrity (PubMed:33063110). Binds to PTCH1 receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes in endothelial cells (PubMed:33063110). In Schwann cells, controls the development of the peripheral nerve sheath and the transition of mesenchymal cells to form the epithelium-like structure of the perineurial tube (PubMed:10482238). [Desert hedgehog protein N-product]: The dually lipidated desert hedgehog protein N-product (DhhNp) is essential for a variety of patterning events during development (By similarity). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (PubMed:9811851). Required for normal testis development and spermatogenesis, namely for the formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules (PubMed:8805249, PubMed:11090455). Activates primary cilia signaling on neighboring valve interstitial cells through a paracrine mechanism (PubMed:32151560). May induce motor neurons in lateral neural tube and may have a polarizing activity. Prevents the desert hedgehog protein precursor binding to PTCH1 (By similarity). Binds PTCH2 (PubMed:9811851). [Desert hedgehog protein]: Reaction=cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]- C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl- [protein]; Xref=Rhea:RHEA:59504, Rhea:RHEA-COMP:12707, Rhea:RHEA- COMP:15369, Rhea:RHEA-COMP:15374, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:65250, ChEBI:CHEBI:143135, ChEBI:CHEBI:143140; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59505; Evidence=; [Desert hedgehog protein N-product]: Multimer. Interacts with BOC and CDON. Interacts with HHIP. [Desert hedgehog protein N-product]: Cell membrane ; Lipid-anchor [Desert hedgehog protein]: Endoplasmic reticulum membrane Golgi apparatus membrane Secreted Cell membrane Note=Co-localizes with HHAT in the ER and Golgi membrane. Expressed in adult testes (PubMed:8805249). Not expressed in limb buds. First detected at 11.5 dpc in the presumptive testis (PubMed:8805249). No expression in the ovary at this or any later time (PubMed:8805249). At 12.5 dpc testis expression is confined to Sertoli cells and is not detected in precursors of the androgen- producing interstitial somatic cells (the Leydig cells) (PubMed:8805249). At 13 dpc expressed by Schwann cell precursors both in the dorsal and ventral roots and in the emerging spinal nerves (PubMed:10482238). Expressed in Schwann cells of newborn (PubMed:10482238). Expressed primarily within the valve endocardium at 15.5 dpc with lower levels of expression within the trabeculated endothelium, primary atrial septum and epicardium (PubMed:32151560). Expressed within the valve endocardium at embryonic, fetal and neonatal timepoints with evidence of protein diffusion into the interstitium (PubMed:32151560). Primarily expressed within the atrialis aspect of the anterior and posterior mitral leaflets with the highest signal present at the valve tip (PubMed:32151560). [Desert hedgehog protein N-product]: Binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein- protein interactions mediated by this domain. [Desert hedgehog protein]: The C-terminal domain regulates the auto-processing and controls the juxtacrine signaling. [Desert hedgehog protein]: Partially autoproteolyzed (By similarity). The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (DhhN) (By similarity). [Desert hedgehog protein N-product]: N-palmitoylation by HHAT of DhhN is required for desert hedgehog protein N-product multimerization and full activity (By similarity). Female mice homozygous for the Dhh gene are fully viable and fertile, whereas male mice are viable but infertile, owing to a complete absence of mature sperm (PubMed:8805249). Male mice exhibit a dramatic reduction in testicular growth (PubMed:8805249). The severity of the phenotype varies depending upon the genetic background of the mice (PubMed:8805249). The majority of the Dhh-null males are pseudohermaphrodites with a blind vaginal opening and evidence of teats. These mice show anastomotic seminiferous tubules, pertitubular cell abnormalities, and absence of adult-type Leydig cells (PubMed:11090455). Belongs to the hedgehog family. osteoblast differentiation cell fate specification patched binding calcium ion binding extracellular region extracellular space plasma membrane proteolysis smoothened signaling pathway cell-cell signaling multicellular organism development spermatid development peptidase activity zinc ion binding regulation of gene expression membrane intein-mediated protein splicing hydrolase activity male sex determination response to estradiol Leydig cell differentiation myelination response to estrogen metal ion binding regulation of steroid biosynthetic process uc007xoh.1 uc007xoh.2 uc007xoh.3 uc007xoh.4 uc007xoh.5 
ENSMUST00000023741.16 Kmt2d ENSMUST00000023741.16 lysine (K)-specific methyltransferase 2D (from RefSeq NM_001033276.3) A0A0A0MQ73 A0A0A0MQ73_MOUSE ENSMUST00000023741.1 ENSMUST00000023741.10 ENSMUST00000023741.11 ENSMUST00000023741.12 ENSMUST00000023741.13 ENSMUST00000023741.14 ENSMUST00000023741.15 ENSMUST00000023741.2 ENSMUST00000023741.3 ENSMUST00000023741.4 ENSMUST00000023741.5 ENSMUST00000023741.6 ENSMUST00000023741.7 ENSMUST00000023741.8 ENSMUST00000023741.9 Kmt2d NM_001033276 uc029suy.1 uc029suy.2 uc029suy.3 Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265; Evidence=; Nucleus nucleus positive regulation of cell proliferation histone-lysine N-methyltransferase activity positive regulation of intracellular estrogen receptor signaling pathway histone lysine methylation histone methyltransferase complex histone methyltransferase activity (H3-K4 specific) response to estrogen transcription regulatory region DNA binding MLL3/4 complex positive regulation of transcription from RNA polymerase II promoter metal ion binding histone H3-K4 methylation uc029suy.1 uc029suy.2 uc029suy.3 
ENSMUST00000023747.14 Nckap5l ENSMUST00000023747.14 NCK-associated protein 5-like (from RefSeq NM_001403554.1) Cep169 ENSMUST00000023747.1 ENSMUST00000023747.10 ENSMUST00000023747.11 ENSMUST00000023747.12 ENSMUST00000023747.13 ENSMUST00000023747.2 ENSMUST00000023747.3 ENSMUST00000023747.4 ENSMUST00000023747.5 ENSMUST00000023747.6 ENSMUST00000023747.7 ENSMUST00000023747.8 ENSMUST00000023747.9 NCK5L_MOUSE NM_001403554 Q6GQX2 Q8BX75 Q8R364 uc007xpn.1 uc007xpn.2 uc007xpn.3 Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules. Both tubulin-binding and homodimer formation are required for NCKAP5L- mediated microtubule bundle formation. Homodimer. Interacts with CDK5RAP2. Interacts with MAPRE1. Interacts with beta-tubulin. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to microtubule plus ends. Associates with centrosomes during interphase, but dissociates from these structures from the onset of mitosis. CDK1/Cyclin B-dependent phosphorylation mediates its dissociation from centrosomes during mitosis. microtubule bundle formation molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton microtubule microtubule depolymerization microtubule plus-end uc007xpn.1 uc007xpn.2 uc007xpn.3 
ENSMUST00000023749.15 Tmbim6 ENSMUST00000023749.15 transmembrane BAX inhibitor motif containing 6, transcript variant 4 (from RefSeq NM_026669.4) BI1_MOUSE ENSMUST00000023749.1 ENSMUST00000023749.10 ENSMUST00000023749.11 ENSMUST00000023749.12 ENSMUST00000023749.13 ENSMUST00000023749.14 ENSMUST00000023749.2 ENSMUST00000023749.3 ENSMUST00000023749.4 ENSMUST00000023749.5 ENSMUST00000023749.6 ENSMUST00000023749.7 ENSMUST00000023749.8 ENSMUST00000023749.9 NM_026669 Q3TX81 Q8BFY4 Q9D2C7 Tegt uc007xpm.1 uc007xpm.2 uc007xpm.3 uc007xpm.4 Suppressor of apoptosis (By similarity). Modulates unfolded protein response signaling (By similarity). Modulates ER calcium homeostasis by acting as a calcium-leak channel (By similarity). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (PubMed:21926971). Interacts with BCL2 (By similarity). Interacts with BCL2L1 (PubMed:21926971). Endoplasmic reticulum membrane ; Multi-pass membrane protein Highly abundant in adult testis. The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into the cytosol. Belongs to the BI1 family. cytoplasm endoplasmic reticulum endoplasmic reticulum membrane autophagy apoptotic process response to unfolded protein negative regulation of calcium ion transport into cytosol membrane integral component of membrane enzyme binding ubiquitin protein ligase binding mitochondrial membrane negative regulation of protein binding endoplasmic reticulum calcium ion homeostasis negative regulation of RNA splicing cellular response to unfolded protein response to endoplasmic reticulum stress negative regulation of apoptotic process negative regulation of immunoglobulin secretion endoribonuclease inhibitor activity negative regulation of endoribonuclease activity intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress response to L-glutamate negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress negative regulation of apoptotic signaling pathway uc007xpm.1 uc007xpm.2 uc007xpm.3 uc007xpm.4 
ENSMUST00000023750.9 Faim2 ENSMUST00000023750.9 Fas apoptotic inhibitory molecule 2, transcript variant 1 (from RefSeq NM_028224.4) ENSMUST00000023750.1 ENSMUST00000023750.2 ENSMUST00000023750.3 ENSMUST00000023750.4 ENSMUST00000023750.5 ENSMUST00000023750.6 ENSMUST00000023750.7 ENSMUST00000023750.8 Kiaa0950 LFG2_MOUSE Lfg Lfg2 NM_028224 Nmp35 Q3TY22 Q8K097 Q8K1F6 Q9D6K4 uc007xpq.1 uc007xpq.2 uc007xpq.3 uc007xpq.4 Antiapoptotic protein which protects cells uniquely from Fas- induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. Interacts with FAS/TNFRSF6 and BAX. Cell membrane ; Multi-pass membrane protein Membrane raft Postsynaptic cell membrane Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long, LFG-L; IsoId=Q8K097-1; Sequence=Displayed; Name=2; Synonyms=Short, LFG-S; IsoId=Q8K097-2; Sequence=VSP_008994; Brain. Highly expressed in cerebellum, also found in cortex, olfactory bulb, and hippocampus. Mice show reduced cerebellar size and internal granular layer (IGL) thickness in early developmental stages, delayed Purkinje Cell (PC) development, with an abnormal morphology and reduced cellular density, increased caspase-8 and caspase-3 activity in PCs and higher sensitivity to Fas-mediated apoptosis. Belongs to the BI1 family. LFG subfamily. Sequence=BAC98056.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; response to ischemia protein binding endoplasmic reticulum Golgi apparatus plasma membrane apoptotic process central nervous system development membrane integral component of membrane cerebellum development cerebellar Purkinje cell layer development cerebellar granular layer development cerebellar Purkinje cell differentiation cell junction regulation of neuron apoptotic process negative regulation of neuron apoptotic process membrane raft synapse postsynaptic membrane negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of apoptotic signaling pathway uc007xpq.1 uc007xpq.2 uc007xpq.3 uc007xpq.4 
ENSMUST00000023752.6 Aqp2 ENSMUST00000023752.6 aquaporin 2 (from RefSeq NM_009699.3) Aqp2 ENSMUST00000023752.1 ENSMUST00000023752.2 ENSMUST00000023752.3 ENSMUST00000023752.4 ENSMUST00000023752.5 NM_009699 Q3UQD4 Q3UQD4_MOUSE uc007xps.1 uc007xps.2 uc007xps.3 uc007xps.4 Apical cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Lateral cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the MIP/aquaporin (TC 1.A.8) family. renal water homeostasis water transmembrane transporter activity plasma membrane integral component of plasma membrane water transport glycerol transmembrane transporter activity water channel activity channel activity porin activity glycerol transport membrane integral component of membrane apical plasma membrane pore complex protein homotetramerization transmembrane transport extracellular exosome cellular response to copper ion cellular response to mercury ion uc007xps.1 uc007xps.2 uc007xps.3 uc007xps.4 
ENSMUST00000023756.12 Racgap1 ENSMUST00000023756.12 Rac GTPase-activating protein 1, transcript variant 7 (from RefSeq NR_177957.1) ENSMUST00000023756.1 ENSMUST00000023756.10 ENSMUST00000023756.11 ENSMUST00000023756.2 ENSMUST00000023756.3 ENSMUST00000023756.4 ENSMUST00000023756.5 ENSMUST00000023756.6 ENSMUST00000023756.7 ENSMUST00000023756.8 ENSMUST00000023756.9 Mgcracgap NR_177957 Q3THR5 Q3TI41 Q3TM81 Q9WVM1 RGAP1_MOUSE Racgap1 uc007xpz.1 uc007xpz.2 uc007xpz.3 uc007xpz.4 Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Has a critical role in erythropoiesis (By similarity). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex. Associates with alpha-, beta- and gamma-tubulin and microtubules. Interacts via its Rho-GAP domain with RND2. Associates with AURKB during M phase. Interacts via its Rho-GAP domain and basic region with PRC1. The interaction with PRC1 inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology. Interacts with SLC26A8 via its N-terminus. Interacts with RAB11FIP3. Interacts with ECT2; the interaction is direct, occurs at anaphase and during cytokinesis in a microtubule-dependent manner, is enhanced by phosphorylation by PLK1 and phosphorylation at Ser-165 plays a major role in mediating binding. Interacts with KIF23; the interaction is direct. Nucleus Cytoplasm Cytoplasm, cytoskeleton, spindle Cytoplasmic vesicle, secretory vesicle, acrosome Cleavage furrow Midbody, Midbody ring Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody ring, also called Flemming body. Colocalizes with RHOA at the myosin contractile ring during cytokinesis. Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase (By similarity). Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and the acrosome. Highly expressed in testis, thymus and spleen and weakly expressed in brain, heart, skeletal muscle and kidney. In testis, expression is restricted to germ cells with the highest levels of expression found in spermatocytes. Not detected in adult liver. Also expressed in fetal liver and in several hematopoietic cell lines. At 6.5 dpc expressed in primitive endoderm, embryonic ectoderm, extraembryonic ectoderm and the ectoplacental cone. By 7.5 dpc, a widespread expression was observed in all intra- and extraembryonic tissues and also in the giant cells lining the inner boundary of the deciduum. At 9.5 dpc, expression was elevated in the neuroepithelium of the brain ventricles and the neural tube. By 12.5 dpc, expression remains widespread and in the brain higher levels were observed in the ventricular zone of the two telencephalic lobes, and in the mesencephalon and diencephalon, with the exception of the median sulcus. In adult brain, highest levels of expression were detected in cerebellum, specifically the Purkinje cell layer extending into the molecular layer. Expression is down-regulated during macrophage differentiation of M1 cells. The coiled coil region is indispensible for localization to the midbody during cytokinesis. The phorbol-ester/DAG-type zinc finger domain mediates interaction with membranes enriched in phosphatidylinositol 3,4,5- trisphosphate and is required during mitotic cytokinesis for normal attachment of the midbody to the cell membrane. Phosphorylated at multiple sites in the midbody during cytokinesis (By similarity). Phosphorylation by AURKB on Ser-388 at the midbody is, at least in part, responsible for exerting its latent GAP activity towards RhoA (By similarity). Phosphorylation on multiple serine residues by PLK1 enhances its association with ECT2 and is critical for cleavage furrow formation (By similarity). Phosphorylation on Ser-165 plays a major role in mediating interaction with ECT2 (By similarity). Phosphorylation on Ser-158 does not appear to contribute to binding to ECT2 (By similarity). mitotic cytokinesis actomyosin contractile ring assembly acrosomal vesicle GTPase activator activity phosphatidylinositol-3,4,5-trisphosphate binding nucleus nucleoplasm cytoplasm spindle cytoskeleton plasma membrane ion transport cell cycle signal transduction multicellular organism development spermatogenesis neuroblast proliferation microtubule binding sulfate transport lipid binding membrane protein kinase binding cell differentiation midbody extrinsic component of cytoplasmic side of plasma membrane cytoplasmic vesicle cleavage furrow positive regulation of cytokinesis intracellular signal transduction alpha-tubulin binding gamma-tubulin binding positive regulation of GTPase activity regulation of embryonic development metal ion binding beta-tubulin binding spindle midzone mitotic spindle midzone assembly cell division regulation of attachment of spindle microtubules to kinetochore mitotic spindle Flemming body centralspindlin complex uc007xpz.1 uc007xpz.2 uc007xpz.3 uc007xpz.4 
ENSMUST00000023758.9 Asic1 ENSMUST00000023758.9 acid-sensing ion channel 1, transcript variant 1 (from RefSeq NM_009597.2) ASIC1_MOUSE Accn2 Asic Bnac2 ENSMUST00000023758.1 ENSMUST00000023758.2 ENSMUST00000023758.3 ENSMUST00000023758.4 ENSMUST00000023758.5 ENSMUST00000023758.6 ENSMUST00000023758.7 ENSMUST00000023758.8 NM_009597 Q50K97 Q6NXK8 uc007xqa.1 uc007xqa.2 uc007xqa.3 uc007xqa.4 Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. Inhibited by the diuretic amiloride. Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with PRKCABP and ASIC2 (By similarity). Interacts with STOM (PubMed:15471860). Q6NXK8-1; Q12791: KCNMA1; Xeno; NbExp=2; IntAct=EBI-15686410, EBI-1220676; Cell membrane ; Multi-pass membrane protein Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Asic1a, Asic alpha; IsoId=Q6NXK8-1; Sequence=Displayed; Name=2; Synonyms=Asic1b, Asic beta; IsoId=Q6NXK8-2; Sequence=VSP_015614, VSP_015615; Expressed in brain areas receiving strong excitatory corticofugal input. In hippocampus, expressed in the hilus of the dentate gyrus. In the cerebral cortex expressed in anterior and posterior cingulate cortex, sensory and motor cortices. In the sensory cortex strongest expression is detected in the whisker barrel field. In sensorimotor and cingulate cortex expression is elevated in layer III. Also expressed in basal ganglia, striatum, ventral pallidum, olfactory tubercle, and nucleus accumbens. Weakly expressed in thalamus with the exception of the habenula and the medial septal nuclei. In olfactory bulb, preferentially expressed in the glomerular layer, within glomeruli. Expressed in cerebellum in the molecular and granule cell layers. Strongly expressed in amygdala complex, particularly in the lateral and basolateral nuclei. Isoform 1 is more abundant in brain compared to isoform 2 (at protein level). Expressed in the nodose ganglion and dorsal root ganglion. Expressed in dendritic spine cells. Channel opening involves a conformation change that affects primarily the extracellular domain and the second transmembrane helix and its orientation in the membrane. In the open state, the second transmembrane helix is nearly perpendicular to the plane of the membrane; in the desensitized state it is strongly tilted. Besides, the second transmembrane domain is discontinuously helical in the open state. The GAS motif of the selectivity filter is in an extended conformation, giving rise to a distinct kink in the polypeptide chain. A domain swap between subunits gives rise to a full-length transmembrane helix (By similarity). Phosphorylation by PKA regulates interaction with PRKCABP and subcellular location. Phosphorylation by PKC may regulate the channel (By similarity). Mice display reduced spatial learning and memory capability, associated with absence of proton-gated currents in hippocampal neurons and impairment of hippocampal long term potentiation (LTP). They also show an increased mechanosensitivity of colonic and gastroesophageal mechanoreceptors and prolonged gastric emptying and an altered fear conditioning. Potentiated by Ca(2+), Mg(2+), Ba(2+), multivalent cations and potentiated by FMRFamide-related neuropeptides. PH dependence may be regulated by serine proteases. Inhibited by anti- inflammatory drugs like salicylic acid (By similarity). Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily. behavioral fear response response to amphetamine ion channel activity cation channel activity sodium channel activity protein binding Golgi apparatus plasma membrane integral component of plasma membrane ion transport cation transport sodium ion transport calcium ion transport memory associative learning cell surface response to acidic pH monovalent inorganic cation transmembrane transporter activity ligand-gated sodium channel activity monovalent inorganic cation transport membrane integral component of membrane ion gated channel activity ion transmembrane transport sodium ion transmembrane transport regulation of membrane potential dendritic spine dendritic shaft acid-sensing ion channel activity synapse negative regulation of neurotransmitter secretion sensory perception of sour taste protein homotrimerization calcium ion transmembrane transport cellular response to pH uc007xqa.1 uc007xqa.2 uc007xqa.3 uc007xqa.4 
ENSMUST00000023759.6 Smarcd1 ENSMUST00000023759.6 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1, transcript variant 1 (from RefSeq NM_031842.3) Baf60a D15Kz1 ENSMUST00000023759.1 ENSMUST00000023759.2 ENSMUST00000023759.3 ENSMUST00000023759.4 ENSMUST00000023759.5 NM_031842 P70384 Q61466 Q8R0I7 SMRD1_MOUSE uc007xqb.1 uc007xqb.2 uc007xqb.3 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (By similarity). Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B), and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (PubMed:8804307, PubMed:8895581). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (PubMed:17640523). Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (ACTB) (By similarity). Component of SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). Specifically interacts with the VDR heterodimer complex. Interacts with ESR1, NR3C1, NR1H4, PGR, SMARCA4, SMARCC1 and SMARCC2 (By similarity). Interacts with DPF2 (By similarity). Interacts with DPF3a (isoform 2 of DPF3/BAF45C) and with HDGFL2 in a DPF3a-dependent manner (By similarity). Interacts with FOS, FOSB isoform 1 and 2, FOSL1 and FOSL2 (PubMed:29272704). Interacts with AKIRIN2 (PubMed:25107474). Q61466; B1AXD8: Akirin2; NbExp=2; IntAct=EBI-371529, EBI-10107866; Q61466; P97496: Smarcc1; NbExp=3; IntAct=EBI-371529, EBI-648047; Q61466; P70323: Tbx1; NbExp=3; IntAct=EBI-371529, EBI-13635846; Q61466; P02340: Tp53; NbExp=4; IntAct=EBI-371529, EBI-474016; Nucleus Ubiquitous. Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at 10.5-16.5 dpc. Belongs to the SMARCD family. Sequence=AAA53377.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAA53377.1; Type=Frameshift; Evidence=; Sequence=AAC52794.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAC52794.1; Type=Frameshift; Evidence=; Sequence=AAH26783.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; chromatin binding receptor binding protein binding nucleus nucleoplasm chromatin organization nucleosome disassembly chromatin remodeling nervous system development SWI/SNF complex intracellular membrane-bounded organelle chromatin-mediated maintenance of transcription binding, bridging cellular response to fatty acid npBAF complex nBAF complex uc007xqb.1 uc007xqb.2 uc007xqb.3 
ENSMUST00000023760.13 Gpd1 ENSMUST00000023760.13 glycerol-3-phosphate dehydrogenase 1 (soluble) (from RefSeq NM_010271.3) ENSMUST00000023760.1 ENSMUST00000023760.10 ENSMUST00000023760.11 ENSMUST00000023760.12 ENSMUST00000023760.2 ENSMUST00000023760.3 ENSMUST00000023760.4 ENSMUST00000023760.5 ENSMUST00000023760.6 ENSMUST00000023760.7 ENSMUST00000023760.8 ENSMUST00000023760.9 GPDA_MOUSE Gdc-1 Gdc1 Gpd1 Kiaa4010 NM_010271 P13707 Q3UVM3 Q5DTS5 uc007xqd.1 uc007xqd.2 uc007xqd.3 uc007xqd.4 Has glycerol-3-phosphate dehydrogenase activity. Reaction=NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH; Xref=Rhea:RHEA:11092, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57597, ChEBI:CHEBI:57642, ChEBI:CHEBI:57945; EC=1.1.1.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11093; Evidence=; Homodimer. Cytoplasm Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. Sequence=BAD90479.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; glycerol-3-phosphate dehydrogenase [NAD+] activity glycerol-3-phosphate dehydrogenase activity cytoplasm mitochondrion cytosol carbohydrate metabolic process glycerol-3-phosphate metabolic process gluconeogenesis NADH oxidation glycerophosphate shuttle NADH metabolic process glycerol-3-phosphate dehydrogenase complex oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor protein homodimerization activity positive regulation of glycolytic process glycerol-3-phosphate catabolic process glycerolipid metabolic process NAD binding oxidation-reduction process cellular response to cAMP cellular response to tumor necrosis factor uc007xqd.1 uc007xqd.2 uc007xqd.3 uc007xqd.4 
ENSMUST00000023761.4 Cox14 ENSMUST00000023761.4 cytochrome c oxidase assembly protein 14 (from RefSeq NM_183256.3) COX14_MOUSE ENSMUST00000023761.1 ENSMUST00000023761.2 ENSMUST00000023761.3 NM_183256 Q8BH51 uc007xqe.1 uc007xqe.2 uc007xqe.3 uc007xqe.4 Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1. Along with COA3, core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Mitochondrion outer membrane ; Single-pass membrane protein molecular_function mitochondrion membrane integral component of membrane mitochondrial membrane mitochondrial respiratory chain complex IV assembly uc007xqe.1 uc007xqe.2 uc007xqe.3 uc007xqe.4 
ENSMUST00000023762.13 Cers5 ENSMUST00000023762.13 ceramide synthase 5 (from RefSeq NM_028015.2) CERS5_MOUSE Cers5 ENSMUST00000023762.1 ENSMUST00000023762.10 ENSMUST00000023762.11 ENSMUST00000023762.12 ENSMUST00000023762.2 ENSMUST00000023762.3 ENSMUST00000023762.4 ENSMUST00000023762.5 ENSMUST00000023762.6 ENSMUST00000023762.7 ENSMUST00000023762.8 ENSMUST00000023762.9 Lass5 NM_028015 Q3UL17 Q80YB2 Q8BPH6 Q921T8 Q924Z3 Q9D6K9 Trh4 uc007xqf.1 uc007xqf.2 uc007xqf.3 Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:12912983, PubMed:15823095, PubMed:16100120, PubMed:17977534, PubMed:17609214, PubMed:26853464). Can use other acyl donors, but with less efficiency (PubMed:15823095). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:12912983, PubMed:15823095, PubMed:15772421, PubMed:17977534). Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (PubMed:15772421). Reaction=a sphingoid base + hexadecanoyl-CoA = an N-hexadecanoyl- sphingoid base + CoA + H(+); Xref=Rhea:RHEA:61472, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:84410, ChEBI:CHEBI:144703; EC=2.3.1.291; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61473; Evidence= Reaction=hexadecanoyl-CoA + sphinganine = CoA + H(+) + N- hexadecanoylsphinganine; Xref=Rhea:RHEA:36539, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57817, ChEBI:CHEBI:67042; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36540; Evidence= Reaction=hexadecanoyl-CoA + hexadecasphinganine = CoA + H(+) + N- hexadecanoylhexadecasphinganine; Xref=Rhea:RHEA:43040, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:71009, ChEBI:CHEBI:82810; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43041; Evidence=; Reaction=hexadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N- hexadecanoylsphing-4-enine; Xref=Rhea:RHEA:36687, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57756, ChEBI:CHEBI:72959; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36688; Evidence=; Reaction=2-hydroxyhexadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2- hydroxyhexadecanoyl)-sphinganine; Xref=Rhea:RHEA:36647, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:67043, ChEBI:CHEBI:74115; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36648; Evidence=; Reaction=sphinganine + tetradecanoyl-CoA = CoA + H(+) + N- (tetradecanoyl)-sphinganine; Xref=Rhea:RHEA:36571, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:57817, ChEBI:CHEBI:67045; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36572; Evidence=; Reaction=octadecanoyl-CoA + sphinganine = CoA + H(+) + N- (octadecanoyl)-sphinganine; Xref=Rhea:RHEA:36547, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57817, ChEBI:CHEBI:67033; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36548; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + sphinganine = CoA + H(+) + N-(9Z- octadecenoyl)-sphinganine; Xref=Rhea:RHEA:36575, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57817, ChEBI:CHEBI:74100; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36576; Evidence=; Reaction=a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+); Xref=Rhea:RHEA:23768, ChEBI:CHEBI:15378, ChEBI:CHEBI:52639, ChEBI:CHEBI:57287, ChEBI:CHEBI:57756, ChEBI:CHEBI:77636; EC=2.3.1.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23769; Evidence=; Inhibited by fumonisin B1. Kinetic parameters: KM=1.8 uM for sphinganine ; KM=3.6 uM for sphinganine ; Vmax=215 pmol/min/mg enzyme with sphinganine as substrate ; Lipid metabolism; sphingolipid metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D6K9-1; Sequence=Displayed; Name=2; IsoId=Q9D6K9-2; Sequence=VSP_011192, VSP_011193; Ubiquitously expressed, with highest levels in testis and kidney (PubMed:12912983, PubMed:15823095). Expressed in pulmonary epithelia (PubMed:15772421). Expressed in lungs of 15 days old fetuses followed by a modest peak at day 17, thereafter decreasing in adult lungs. The last loop motif confers selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor. Phosphorylated at the C-terminus by CK2. Mice are viable and show no apparent morphological alterations in normal conditions (PubMed:26853464). Decreased palmitoyl (C16:0) ceramide pools (PubMed:26853464). According to a report, deletion of Cers5 protects from obesity: knockout mice are associated with reduced weight gain and improved systemic health after high fat diet challenge (PubMed:26853464). This result was however not confirmed by another study, which did not observe any protection from diet-induced obesity in knockout mice (PubMed:31150623). Effects observed in the first study might be indirect and caused by a large deletion that affects neighboring genes and/or deletes non-coding RNAs (PubMed:26853464, PubMed:31150623). Some prediction bioinformatics tools predict the presence of a homeobox domain (By similarity). However, the domain is degenerate and residues that are important for DNA-binding are absent (By similarity). Moreover, the protein localizes in the endoplasmic reticulum and not in the nucleus, strongly suggesting that it does not constitute a canonical homeobox domain (PubMed:12912983). DNA binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process sphingolipid metabolic process membrane integral component of membrane transferase activity sphingolipid biosynthetic process ceramide biosynthetic process sphingosine N-acyltransferase activity uc007xqf.1 uc007xqf.2 uc007xqf.3 
ENSMUST00000023769.11 Atf1 ENSMUST00000023769.11 activating transcription factor 1, transcript variant 1 (from RefSeq NM_007497.4) ATF1_MOUSE ENSMUST00000023769.1 ENSMUST00000023769.10 ENSMUST00000023769.2 ENSMUST00000023769.3 ENSMUST00000023769.4 ENSMUST00000023769.5 ENSMUST00000023769.6 ENSMUST00000023769.7 ENSMUST00000023769.8 ENSMUST00000023769.9 NM_007497 P81269 uc007xqs.1 uc007xqs.2 uc007xqs.3 Binds the cAMP response element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity). Binds DNA as a dimer. Interacts with HIPK2 and CDK3. Interacts with MOTS-c, a peptide produced by the mitochondrially encoded 12S rRNA MT-RNR1; the interaction occurs in the nucleus following metabolic stress. Nucleus Phosphorylated at Ser-196 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities (By similarity). Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. Belongs to the bZIP family. ATF subfamily. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of neuron projection development response to organic cyclic compound response to cobalt ion cellular macromolecular complex assembly identical protein binding sequence-specific DNA binding macromolecular complex binding positive regulation of DNA replication positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity ATF1-ATF4 transcription factor complex uc007xqs.1 uc007xqs.2 uc007xqs.3 
ENSMUST00000023774.12 Slc11a2 ENSMUST00000023774.12 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2, transcript variant 2 (from RefSeq NM_008732.2) Dct1 Dmt1 ENSMUST00000023774.1 ENSMUST00000023774.10 ENSMUST00000023774.11 ENSMUST00000023774.2 ENSMUST00000023774.3 ENSMUST00000023774.4 ENSMUST00000023774.5 ENSMUST00000023774.6 ENSMUST00000023774.7 ENSMUST00000023774.8 ENSMUST00000023774.9 NM_008732 NRAM2_MOUSE Nramp2 O54903 P49282 Q3UFV5 Q8BJL2 Q8BWV3 Q8CFA0 Q8VCU6 uc007xrc.1 uc007xrc.2 uc007xrc.3 uc007xrc.4 Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:16475818). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (By similarity) (PubMed:16475818). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (PubMed:11739192). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (By similarity). Can mediate uncoupled fluxes of either protons or metal ions. [Isoform 1]: Reaction=Fe(2+)(in) + H(+)(in) = Fe(2+)(out) + H(+)(out); Xref=Rhea:RHEA:29579, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29580; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29581; Evidence=; [Isoform 1]: Reaction=Co(2+)(out) + H(+)(out) = Co(2+)(in) + H(+)(in); Xref=Rhea:RHEA:73035, ChEBI:CHEBI:15378, ChEBI:CHEBI:48828; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73036; Evidence=; [Isoform 2]: Reaction=Fe(2+)(in) + H(+)(in) = Fe(2+)(out) + H(+)(out); Xref=Rhea:RHEA:29579, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29580; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29581; Evidence=; [Isoform 2]: Reaction=Co(2+)(out) + H(+)(out) = Co(2+)(in) + H(+)(in); Xref=Rhea:RHEA:73035, ChEBI:CHEBI:15378, ChEBI:CHEBI:48828; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73036; Evidence=; Reaction=Cd(2+)(out) + H(+)(out) = Cd(2+)(in) + H(+)(in); Xref=Rhea:RHEA:73031, ChEBI:CHEBI:15378, ChEBI:CHEBI:48775; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73032; Evidence=; Reaction=H(+)(in) + Mn(2+)(in) = H(+)(out) + Mn(2+)(out); Xref=Rhea:RHEA:29007, ChEBI:CHEBI:15378, ChEBI:CHEBI:29035; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29008; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29009; Evidence= Reaction=H(+)(out) + Zn(2+)(out) = H(+)(in) + Zn(2+)(in); Xref=Rhea:RHEA:71195, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71196; Evidence= Reaction=H(+)(out) + Ni(2+)(out) = H(+)(in) + Ni(2+)(in); Xref=Rhea:RHEA:73039, ChEBI:CHEBI:15378, ChEBI:CHEBI:49786; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73040; Evidence= Reaction=H(+)(in) = H(+)(out); Xref=Rhea:RHEA:34979, ChEBI:CHEBI:15378; Evidence=; Reaction=Fe(2+)(in) = Fe(2+)(out); Xref=Rhea:RHEA:28486, ChEBI:CHEBI:29033; Evidence=; Forms a complex with NDFIP1 and NEDD4L, in cortical neurons, in response to iron and cobalt exposure; this interaction leads to SLC11A2 ubiquitination by NEDD4L and proteasome-dependent degradation (By similarity). Interacts with NDFIP1, NDFIP2 and WWP2; this interaction leads to SLC11A2 ubiquitination by WWP2 and subsequent proteasome-dependent degradation (PubMed:18776082). Interacts with COX2 and TOM6 at the outer mitochondrion membrane (By similarity). Interacts with ARRDC1; this interaction regulates the incorporation of SLC11A2 into extracellular vesicles through an ubiquitination-dependent mechanism (By similarity). Interacts with ARRDC4; controls the incorporation of SLC11A2 into extracellular vesicles through an ubiquitination-dependent mechanism (By similarity). [Isoform 1]: Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Early endosome membrane ulti-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein [Isoform 2]: Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Mitochondrion outer membrane ; Multi-pass membrane protein Extracellular vesicle membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=2; Synonyms=Non-IRE; IsoId=P49282-1; Sequence=Displayed; Name=1; Synonyms=IRE; IsoId=P49282-2; Sequence=VSP_003596; Name=3; Synonyms=1A-IRE; IsoId=P49282-3; Sequence=VSP_038145, VSP_003596; Name=4; Synonyms=1A-Non-IRE; IsoId=P49282-4; Sequence=VSP_038145; [Isoform 1]: Abundantly expressed in erythroid precursor cells (at protein level). [Isoform 2]: Expressed in duodenum (at protein level). [Isoform 2]: Up-regulated under iron-depletion conditions in the proximal portion of the duodenum where it is abundantly expressed in the brush border of absorptive epithelial cells (at protein level). Ubiquitinated by WWP2. N-glycosylated. Note=Defects in Slc11a2 are the cause of microcytic anemia (mk). Homozygous mk/mk mice have hypochromic microcytic anemia due to severe defects in intestinal iron absorption and erythroid iron utilization. Mice display no apparent anatomical abnormalities. They are however anemic, show progressive postnatal growth retardation, and at birth have elevated liver iron stores compared with wild-type littermates. None survive for more than 7 days. Heterozygotes appear normal, showing no significant hematological abnormalities. However, by 8 weeks, their liver iron content is lower than in wild-type littermates. Nifedipine induces duodenal iron accumulation and mobilizes iron from the liver of iron-overloaded mice. Belongs to the NRAMP family. Sequence=CAD38518.1; Type=Frameshift; Evidence=; transition metal ion transport response to hypoxia copper ion transmembrane transporter activity iron ion transmembrane transporter activity manganese ion transmembrane transporter activity iron ion binding copper ion binding nucleus cytoplasm mitochondrion mitochondrial outer membrane lysosome lysosomal membrane endosome early endosome late endosome vacuole trans-Golgi network plasma membrane integral component of plasma membrane brush border porphyrin-containing compound metabolic process porphyrin-containing compound biosynthetic process heme biosynthetic process ion transport cobalt ion transport copper ion transport iron ion transport manganese ion transport activation of cysteine-type endopeptidase activity involved in apoptotic process learning or memory zinc ion binding cell surface endosome membrane response to iron ion response to manganese ion endomembrane system hydrogen ion transmembrane transporter activity cadmium ion transmembrane transporter activity cobalt ion transmembrane transporter activity ferrous iron transmembrane transporter activity lead ion transmembrane transporter activity nickel cation transmembrane transporter activity vanadium ion transmembrane transporter activity solute:proton symporter activity nickel cation transport vanadium ion transport lead ion transport membrane integral component of membrane nickel cation binding apical plasma membrane inorganic cation transmembrane transporter activity metal ion transport manganese ion binding cytoplasmic vesicle brush border membrane late endosome membrane iron assimilation cellular response to oxidative stress iron ion transmembrane transport nickel cation transmembrane transport apical part of cell basal part of cell cadmium ion binding metal ion transmembrane transporter activity transition metal ion transmembrane transporter activity perinuclear region of cytoplasm dendrite morphogenesis erythrocyte development cobalt ion binding recycling endosome iron ion homeostasis multicellular organismal iron ion homeostasis cadmium ion transmembrane transport paraferritin complex manganese ion transmembrane transport copper ion import across plasma membrane hydrogen ion transmembrane transport extracellular vesicle retromer complex binding uc007xrc.1 uc007xrc.2 uc007xrc.3 uc007xrc.4 
ENSMUST00000023775.9 Cela1 ENSMUST00000023775.9 chymotrypsin-like elastase family, member 1 (from RefSeq NM_033612.2) CELA1_MOUSE ENSMUST00000023775.1 ENSMUST00000023775.2 ENSMUST00000023775.3 ENSMUST00000023775.4 ENSMUST00000023775.5 ENSMUST00000023775.6 ENSMUST00000023775.7 ENSMUST00000023775.8 Ela1 NM_033612 Q91X79 Q9D936 Q9Z1H1 uc007xrx.1 uc007xrx.2 uc007xrx.3 uc007xrx.4 Serine proteases that hydrolyze many proteins in addition to elastin. Reaction=Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.; EC=3.4.21.36; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Secreted Belongs to the peptidase S1 family. Elastase subfamily. negative regulation of transcription from RNA polymerase II promoter serine-type endopeptidase activity extracellular region extracellular space proteolysis inflammatory response peptidase activity serine-type peptidase activity post-embryonic development Wnt signaling pathway hydrolase activity exocrine pancreas development multicellular organism growth regulation of cell proliferation regulation of cell differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter metal ion binding tissue remodeling digestive system development elastin catabolic process pancreas morphogenesis uc007xrx.1 uc007xrx.2 uc007xrx.3 uc007xrx.4 
ENSMUST00000023776.13 Slc4a8 ENSMUST00000023776.13 solute carrier family 4 (anion exchanger), member 8, transcript variant 1 (from RefSeq NM_021530.2) ENSMUST00000023776.1 ENSMUST00000023776.10 ENSMUST00000023776.11 ENSMUST00000023776.12 ENSMUST00000023776.2 ENSMUST00000023776.3 ENSMUST00000023776.4 ENSMUST00000023776.5 ENSMUST00000023776.6 ENSMUST00000023776.7 ENSMUST00000023776.8 ENSMUST00000023776.9 Kiaa0739 NM_021530 Ndcbe Q3TAV7 Q6A004 Q8BYI7 Q8JZR6 Q9JKV6 S4A8_MOUSE Slc4a8 uc289blw.1 uc289blw.2 Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:20389022). Plays a major role in pH regulation in neurons (PubMed:21593314). Mediates sodium reabsorption in the renal cortical collecting ducts (PubMed:20389022). Reaction=chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) = chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in); Xref=Rhea:RHEA:72739, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101; Evidence=; Homodimer. Cell membrane ulti-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Note=Localizes to synaptic junction cell membrane. Event=Alternative splicing; Named isoforms=2; Name=1 IsoId=Q8JZR6-1; Sequence=Displayed; Name=2 ; IsoId=Q8JZR6-2; Sequence=VSP_052769; Expressed in the hippocampal neurons (at protein level). Highly expressed in brain with lower levels in lung, kidney and heart. In the kidney, there is high expression in the inner medulla, localized to the inner medullary collecting duct. In the brain, there seems to be three transcripts each having a different expression pattern. The smaller 3kb transcript has highest expression levels in the thalamus and the largest 9.5kb transcript has highest levels in the substantia nigra. The middle transcript of 4.4kb, which is also the main transcript in kidney, is highly expressed in thalamus. Hence, the highest levels are observed in the thalamus, amygdala and caudate nucleus and very low expression was seen in the corpus callosum. Belongs to the anion exchanger (TC 2.A.31) family. Sequence=BAD32292.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; inorganic anion exchanger activity plasma membrane ion transport sodium ion transport anion transport anion transmembrane transporter activity sodium:bicarbonate symporter activity antiporter activity anion:anion antiporter activity inorganic anion transport bicarbonate transport membrane integral component of membrane neuronal cell body membrane neuron projection regulation of intracellular pH transmembrane transport anion transmembrane transport uc289blw.1 uc289blw.2 
ENSMUST00000023781.9 Krt88 ENSMUST00000023781.9 keratin 88 (from RefSeq NM_025487.3) 1700011A15Rik ENSMUST00000023781.1 ENSMUST00000023781.2 ENSMUST00000023781.3 ENSMUST00000023781.4 ENSMUST00000023781.5 ENSMUST00000023781.6 ENSMUST00000023781.7 ENSMUST00000023781.8 Krt88 NM_025487 Q9CPR6 Q9CPR6_MOUSE uc007xtg.1 uc007xtg.2 uc007xtg.3 uc007xtg.4 Belongs to the intermediate filament family. molecular_function cellular_component intermediate filament biological_process uc007xtg.1 uc007xtg.2 uc007xtg.3 uc007xtg.4 
ENSMUST00000023786.7 Krt6b ENSMUST00000023786.7 keratin 6B (from RefSeq NM_010669.3) ENSMUST00000023786.1 ENSMUST00000023786.2 ENSMUST00000023786.3 ENSMUST00000023786.4 ENSMUST00000023786.5 ENSMUST00000023786.6 Krt2-6b Krt6b NM_010669 Q3UV11 Q3UV11_MOUSE uc007xtu.1 uc007xtu.2 uc007xtu.3 Belongs to the intermediate filament family. intermediate filament keratin filament uc007xtu.1 uc007xtu.2 uc007xtu.3 
ENSMUST00000023788.8 Krt6a ENSMUST00000023788.8 keratin 6A (from RefSeq NM_008476.4) ENSMUST00000023788.1 ENSMUST00000023788.2 ENSMUST00000023788.3 ENSMUST00000023788.4 ENSMUST00000023788.5 ENSMUST00000023788.6 ENSMUST00000023788.7 K2C6A_MOUSE Ker2 Krt2-6 Krt2-6a Krt6 NM_008476 P50446 Q9Z332 uc007xtv.1 uc007xtv.2 uc007xtv.3 Epidermis-specific type I keratin involved in wound healing (PubMed:10866680). Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration (PubMed:10866680). Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair (PubMed:22529101). Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17 (PubMed:8636216). Interacts with TCHP (By similarity). Predominates in the adult trunk skin, tongue, trachea/esophagus and eye. In adult skin, localization is restricted to hair follicles, where it is localized predominantly in the outer root sheath. With the exception of specific body sites, expression is induced under conditions of epithelial hyperproliferation such as wound healing, certain skin diseases, cancer, and by treatment of the skin with the phorbol ester PMA. Upon wounding, induced in the outer root sheath and the interfollicular epidermis including the basal cell layer (PubMed:10866680). Wound healing defects. Delay in reepithelialization from the hair follicle while the healing of full- thickness skin wounds is not impaired. There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively). Belongs to the intermediate filament family. morphogenesis of an epithelium intermediate filament Wnt signaling pathway keratinization wound healing keratin filament intermediate filament organization defense response to Gram-positive bacterium uc007xtv.1 uc007xtv.2 uc007xtv.3 
ENSMUST00000023790.5 Krt1 ENSMUST00000023790.5 keratin 1 (from RefSeq NM_008473.2) ENSMUST00000023790.1 ENSMUST00000023790.2 ENSMUST00000023790.3 ENSMUST00000023790.4 K2C1_MOUSE Krt2-1 NM_008473 P04104 Q149E0 Q9D2K8 uc007xuc.1 uc007xuc.2 uc007xuc.3 May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity). Heterotetramer of two type I and two type II keratins (PubMed:24940650, PubMed:11408584). Heterodimer with KRT10 (PubMed:24940650). Two heterodimers of KRT1 and KRT10 form a heterotetramer (By similarity). Forms a heterodimer with KRT14; the interaction is more abundant in the absence of KRT5 (PubMed:11408584). Interacts with PLEC isoform 1C, when in a heterodimer with KRT10 (PubMed:24940650). Interacts with ITGB1 in the presence of RACK1 and SRC, and with RACK1 (By similarity). Interacts with C1QBP; the association represents a cell surface kininogen receptor (By similarity). Interacts with EPPK1; interaction is dependent of higher- order structure of intermediate filament (By similarity). Cell membrane Cytoplasm Expressed in the infundibular regions of the ear, the interfollicular epidermis of the back, in the interscale regions containing hair follicles in the tail, and in the soles of the footpads (at protein level). Expressed in the skin at birth. Undergoes deimination of some arginine residues (citrullination). Note=Defects in Krt1 are a cause of epidermolytic hyperkeratosis (EHK); also known as bullous congenital ichthyosiform erythroderma (BIE). EHK is a hereditary skin disorder characterized by intraepidermal blistering, a marked thickening of the stratum corneum, pigmentation of the skin and erosions at sites of trauma which are all present from birth. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. cornified envelope complement activation, lectin pathway intermediate filament plasma membrane membrane peptide cross-linking carbohydrate binding structural constituent of epidermis keratin filament protein heterodimerization activity negative regulation of inflammatory response protein heterotetramerization establishment of skin barrier uc007xuc.1 uc007xuc.2 uc007xuc.3 
ENSMUST00000023797.8 Krt4 ENSMUST00000023797.8 keratin 4 (from RefSeq NM_008475.2) A6H6D6 ENSMUST00000023797.1 ENSMUST00000023797.2 ENSMUST00000023797.3 ENSMUST00000023797.4 ENSMUST00000023797.5 ENSMUST00000023797.6 ENSMUST00000023797.7 K2C4_MOUSE Krt2-4 NM_008475 P07744 Q6P3F5 uc007xuf.1 uc007xuf.2 Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13. Expressed in the dorsal and ventral epithelium of the tongue. Highest expression levels are detected in the suprabasal layer with low levels detected in the basal cell layer. Within the suprabasal layer expression is highest in the spinous cells, decreases in the granular cells and is not detected in the stratum corneum. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. Sequence=AAH64008.1; Type=Erroneous initiation; Evidence=; intermediate filament cytoskeleton organization embryo development ending in birth or egg hatching cell surface epithelial cell differentiation keratin filament intermediate filament cytoskeleton protein heterodimerization activity negative regulation of epithelial cell proliferation uc007xuf.1 uc007xuf.2 
ENSMUST00000023799.8 Krt79 ENSMUST00000023799.8 keratin 79 (from RefSeq NM_146063.1) ENSMUST00000023799.1 ENSMUST00000023799.2 ENSMUST00000023799.3 ENSMUST00000023799.4 ENSMUST00000023799.5 ENSMUST00000023799.6 ENSMUST00000023799.7 K2C79_MOUSE Kb38 NM_146063 Q8K2E4 Q8VED5 uc007xug.1 uc007xug.2 Heterotetramer of two type I and two type II keratins. There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively). Belongs to the intermediate filament family. intermediate filament enzyme binding keratin filament uc007xug.1 uc007xug.2 
ENSMUST00000023803.8 Krt18 ENSMUST00000023803.8 keratin 18 (from RefSeq NM_010664.2) ENSMUST00000023803.1 ENSMUST00000023803.2 ENSMUST00000023803.3 ENSMUST00000023803.4 ENSMUST00000023803.5 ENSMUST00000023803.6 ENSMUST00000023803.7 K1C18_MOUSE Kerd Krt1-18 NM_010664 P05784 Q3TIX1 Q3TJH6 Q3TJW7 Q61766 uc007xuj.1 uc007xuj.2 uc007xuj.3 uc007xuj.4 When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. Heterotetramer of two type I and two type II keratins. KRT18 associates with KRT8 (PubMed:24940650). Interacts with PLEC isoform 1C, when in a heterodimer with KRT8 (PubMed:24940650). Interacts with PNN and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with the thrombin-antithrombin complex. Interacts with DNAJB6, TCHP and TRADD (By similarity). Interacts with FAM83H (By similarity). Interacts with EPPK1 (PubMed:25617501). Interacts with PKP1 and PKP2 (By similarity). Nucleus matrix Cytoplasm, perinuclear region Nucleus, nucleolus Cytoplasm Expressed in endoderm, intestinal epithelial cells and in most extraembryonic tissues. During embryogenesis, expressed in a complex spatial and temporal pattern in various embryonic epithelia. In 7.5 and 13.5 day old embryo, expressed in most endodermal epithelia, ectodermal and nascent mesodermal tissues. When the neural plate forms, expression begins in the cells of skin ectoderm, head process/notochord, periderm, whisker buds, choroid plexus and the epithelia of auditory duct and inner ear. High expression in the lining endodermal cells when the foregut and hindgut invaginations form. Expression in all three layers of the urothelium starts at day 15 in the embryo and is not visible after day 18. By day 11 and 12, the entire embryonic palatal epithelium shows expression as well as the nasal passages and the roof of the mouth; which disappears progresively from day 13 to 15. By retinoic acid and IL-6. Phosphorylation increases by IL-6. Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-231 by either caspase-3, caspas-6 or caspase-7. O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. structural molecule activity protein binding nucleus nucleolus cytoplasm microtubule organizing center cytosol intermediate filament nuclear matrix tumor necrosis factor-mediated signaling pathway centriolar satellite Golgi to plasma membrane CFTR protein transport negative regulation of apoptotic process keratin filament intermediate filament cytoskeleton organization cell periphery scaffold protein binding extrinsic apoptotic signaling pathway hepatocyte apoptotic process uc007xuj.1 uc007xuj.2 uc007xuj.3 uc007xuj.4 
ENSMUST00000023805.3 Csad ENSMUST00000023805.3 cysteine sulfinic acid decarboxylase, transcript variant 30 (from RefSeq NR_183985.1) CSAD_MOUSE Csad ENSMUST00000023805.1 ENSMUST00000023805.2 NR_183985 Q8K566 Q9DBE0 uc007xuu.1 uc007xuu.2 uc007xuu.3 Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate. Reaction=H(+) + L-aspartate = beta-alanine + CO2; Xref=Rhea:RHEA:19497, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29991, ChEBI:CHEBI:57966; EC=4.1.1.11; Evidence=; Reaction=3-sulfino-L-alanine + H(+) = CO2 + hypotaurine; Xref=Rhea:RHEA:16877, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57853, ChEBI:CHEBI:61085; EC=4.1.1.29; Evidence=; Reaction=H(+) + L-cysteate = CO2 + taurine; Xref=Rhea:RHEA:25221, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:58090, ChEBI:CHEBI:507393; EC=4.1.1.29; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Activated by Mn(2+). Inhibited by bis- carboxymethyl-trithiocarbonate, ethylxanthogenacetic acid and 2,5- disulfoaniline. Not affected by Li(+) within 0.05-40 mM concentration range. Kinetic parameters: KM=0.20 mM for 3-sulfino-L-alanine (cysteine sulfinic acid) ; KM=93 mM for L-aspartate ; Vmax=7.22 umol/min/mg enzyme with 3-sulfino-L-alanine (cysteine sulfinic acid) as substrate ; Vmax=0.16 umol/min/mg enzyme with L-aspartate as substrate ; Note=kcat is 6.6 sec(-1) with 3-sulfino-L-alanine (cysteine sulfinic acid) as substrate. kcat is 0.14 sec(-1) with L-aspartate as substrate. ; Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2. Homodimer. Expressed in kidney and liver not detected in lymphoid tissues and lung. Expressed in kidney, liver and brain. 7 and 4 times higher expression in kidney and liver than in brain, respectively. Low level of detection in skeletal muscle. Expressed in brain, olfactory bulb, liver, skeletal muscle and kidney with the highest expression in liver and lowest in skeletal muscle (at protein level) (PubMed:26327310). Expression in the brain decreases with age as detected from 17 dpc to 12 months. Belongs to the group II decarboxylase family. catalytic activity aspartate 1-decarboxylase activity sulfinoalanine decarboxylase activity cellular_component cytoplasm lyase activity carboxy-lyase activity L-cysteine catabolic process to hypotaurine L-cysteine catabolic process to taurine taurine metabolic process carboxylic acid metabolic process pyridoxal phosphate binding taurine biosynthetic process uc007xuu.1 uc007xuu.2 uc007xuu.3 
ENSMUST00000023806.14 Soat2 ENSMUST00000023806.14 sterol O-acyltransferase 2 (from RefSeq NM_146064.1) Acact-2 Acat2 ENSMUST00000023806.1 ENSMUST00000023806.10 ENSMUST00000023806.11 ENSMUST00000023806.12 ENSMUST00000023806.13 ENSMUST00000023806.2 ENSMUST00000023806.3 ENSMUST00000023806.4 ENSMUST00000023806.5 ENSMUST00000023806.6 ENSMUST00000023806.7 ENSMUST00000023806.8 ENSMUST00000023806.9 NM_146064 O88908 Q8R0Y9 SOAT2_MOUSE Soat2 uc007xut.1 uc007xut.2 uc007xut.3 Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)- octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa. Reaction=a long-chain fatty acyl-CoA + a sterol = a sterol ester + CoA; Xref=Rhea:RHEA:59816, ChEBI:CHEBI:15889, ChEBI:CHEBI:35915, ChEBI:CHEBI:57287, ChEBI:CHEBI:83139; EC=2.3.1.26; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59817; Evidence=; Reaction=an acyl-CoA + cholesterol = a cholesterol ester + CoA; Xref=Rhea:RHEA:17729, ChEBI:CHEBI:16113, ChEBI:CHEBI:17002, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17730; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + cholesterol = cholesteryl (9Z- octadecenoate) + CoA; Xref=Rhea:RHEA:41436, ChEBI:CHEBI:16113, ChEBI:CHEBI:46898, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41437; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA; Xref=Rhea:RHEA:46612, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:73862, ChEBI:CHEBI:84969; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46613; Evidence=; Reaction=(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z- octadecatrienoyl)-cholesterol + CoA; Xref=Rhea:RHEA:46620, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:74034, ChEBI:CHEBI:84341; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46621; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA; Xref=Rhea:RHEA:42816, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:82751; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42817; Evidence=; May form homo- or heterodimers (By similarity). Interacts with INSIG1; the interaction is direct and promotes association with AMFR/gp78 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Each protomer consists of 9 transmembrane segments, which enclose a cytosolic tunnel and a transmembrane tunnel that converge at the predicted catalytic site: acyl-CoA enters the active site through the cytosolic tunnel, whereas cholesterol enters from the side through the transmembrane tunnel. Polyubiquitinated by AMFR/gp78 at Cys-280, leading to its degradation when the lipid levels are low. Association with AMFR/gp78 is mediated via interaction with INSIG1. High concentration of cholesterol and fatty acid results in Cys-280 oxidation, preventing ubiquitination at the same site, resulting in protein stabilization. Oxidized at Cys-280: high concentration of cholesterol and fatty acid induce reactive oxygen species, which oxidizes Cys-280, preventing ubiquitination at the same site, and resulting in protein stabilization. Mice are more susceptible to high-fat diet- induced insulin resistance. Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. fatty-acyl-CoA binding sterol O-acyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane brush border lipid metabolic process steroid metabolic process cholesterol metabolic process O-acyltransferase activity cholesterol binding membrane integral component of membrane transferase activity transferase activity, transferring acyl groups cholesterol efflux very-low-density lipoprotein particle assembly cholesterol esterification cholesterol O-acyltransferase activity cholesterol homeostasis uc007xut.1 uc007xut.2 uc007xut.3 
ENSMUST00000023807.7 Igfbp6 ENSMUST00000023807.7 insulin-like growth factor binding protein 6 (from RefSeq NM_008344.3) ENSMUST00000023807.1 ENSMUST00000023807.2 ENSMUST00000023807.3 ENSMUST00000023807.4 ENSMUST00000023807.5 ENSMUST00000023807.6 IBP6_MOUSE Igfbp-6 NM_008344 P47880 Q91X24 uc011zzz.1 uc011zzz.2 uc011zzz.3 IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration. Interacts (via C-terminal domain) with PHB2. Secreted. O-glycosylated. fibronectin binding extracellular matrix structural constituent insulin-like growth factor binding extracellular region extracellular space cytoplasm Golgi apparatus growth factor binding insulin-like growth factor I binding insulin-like growth factor II binding insulin-like growth factor binary complex regulation of insulin-like growth factor receptor signaling pathway uc011zzz.1 uc011zzz.2 uc011zzz.3 
ENSMUST00000023809.11 Amhr2 ENSMUST00000023809.11 anti-Mullerian hormone type 2 receptor, transcript variant 1 (from RefSeq NM_144547.2) AMHR2_MOUSE ENSMUST00000023809.1 ENSMUST00000023809.10 ENSMUST00000023809.2 ENSMUST00000023809.3 ENSMUST00000023809.4 ENSMUST00000023809.5 ENSMUST00000023809.6 ENSMUST00000023809.7 ENSMUST00000023809.8 ENSMUST00000023809.9 NM_144547 Q0VDQ4 Q8K592 uc007xvq.1 uc007xvq.2 uc007xvq.3 uc007xvq.4 On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA- COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Interacts with type I receptor ACVR1. Membrane ; Single-pass type I membrane protein Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type II ATP binding integral component of plasma membrane protein phosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway pattern specification process sex differentiation male gonad development female gonad development membrane integral component of membrane kinase activity phosphorylation transferase activity growth factor binding hormone binding receptor complex SMAD binding metal ion binding anti-Mullerian hormone signaling pathway anti-Mullerian hormone receptor activity uc007xvq.1 uc007xvq.2 uc007xvq.3 uc007xvq.4 
ENSMUST00000023810.12 Prr13 ENSMUST00000023810.12 proline rich 13, transcript variant 1 (from RefSeq NM_025385.3) ENSMUST00000023810.1 ENSMUST00000023810.10 ENSMUST00000023810.11 ENSMUST00000023810.2 ENSMUST00000023810.3 ENSMUST00000023810.4 ENSMUST00000023810.5 ENSMUST00000023810.6 ENSMUST00000023810.7 ENSMUST00000023810.8 ENSMUST00000023810.9 NM_025385 PRR13_MOUSE Q3U3U4 Q9CQJ5 uc007xvr.1 uc007xvr.2 uc007xvr.3 uc007xvr.4 Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis (By similarity). Nucleus molecular_function nucleus biological_process uc007xvr.1 uc007xvr.2 uc007xvr.3 uc007xvr.4 
ENSMUST00000023812.10 Map3k12 ENSMUST00000023812.10 mitogen-activated protein kinase kinase kinase 12, transcript variant 2 (from RefSeq NM_009582.5) ENSMUST00000023812.1 ENSMUST00000023812.2 ENSMUST00000023812.3 ENSMUST00000023812.4 ENSMUST00000023812.5 ENSMUST00000023812.6 ENSMUST00000023812.7 ENSMUST00000023812.8 ENSMUST00000023812.9 M3K12_MOUSE NM_009582 P70286 Q3TLL7 Q60700 Q8C4N7 Q8CBX3 Q8CDL6 Zpk uc007xwd.1 uc007xwd.2 uc007xwd.3 uc007xwd.4 Protein kinase which is part of a non-canonical MAPK signaling pathway (PubMed:7983011, PubMed:8663324, PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Homodimer (PubMed:8663324). Interacts with MBIP (By similarity). Cytoplasm. Cell membrane Note=Behaves essentially as an integral membrane protein. Within the nervous system, predominantly expressed in neurons and enriched in synaptic terminals (PubMed:8663324). Expressed in brain, kidney, lung, heart, testis, gastrointestinal tract, stomach, liver and pancreas (PubMed:8769565, PubMed:7983011). Interacts with MBIP through the leucine-zipper motif. Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated. The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. nucleotide binding activation of MAPKK activity protein kinase activity protein serine/threonine kinase activity JUN kinase kinase kinase activity MAP kinase kinase kinase activity ATP binding cytoplasm cytosol plasma membrane protein phosphorylation JNK cascade activation of JNKK activity activation of JUN kinase activity membrane kinase activity phosphorylation histone phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation protein kinase binding axon growth cone protein homodimerization activity positive regulation of transcription, DNA-templated protein autophosphorylation positive regulation of ERK1 and ERK2 cascade negative regulation of motor neuron apoptotic process uc007xwd.1 uc007xwd.2 uc007xwd.3 uc007xwd.4 
ENSMUST00000023813.9 Tarbp2 ENSMUST00000023813.9 TARBP2, RISC loading complex RNA binding subunit, transcript variant 31 (from RefSeq NR_183772.1) ENSMUST00000023813.1 ENSMUST00000023813.2 ENSMUST00000023813.3 ENSMUST00000023813.4 ENSMUST00000023813.5 ENSMUST00000023813.6 ENSMUST00000023813.7 ENSMUST00000023813.8 NR_183772 P97473 Prbp Q99M41 TRBP2_MOUSE uc007xwf.1 uc007xwf.2 uc007xwf.3 uc007xwf.4 uc007xwf.5 Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity). Binds in vitro to the PRM1 3'-UTR (PubMed:8649414). Seems to act as a repressor of translation (PubMed:8649414). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (PubMed:23063653). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (By similarity). Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 (By similarity). Interacts with DICER1 and PRKRA (PubMed:16142218, PubMed:17452327). Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (By similarity). Interacts with IRF7; this interaction prevents IRF7 phosphorylation and activation (By similarity). Cytoplasm toplasm, perinuclear region Nucleus Belongs to the TARBP2 family. RNA binding double-stranded RNA binding protein binding nucleus nucleoplasm cytoplasm regulation of translation spermatid development single fertilization RISC complex nuclear body enzyme binding production of siRNA involved in RNA interference targeting of mRNA for destruction involved in RNA interference gene silencing by RNA pre-miRNA processing siRNA loading onto RISC involved in RNA interference production of miRNAs involved in gene silencing by miRNA siRNA binding miRNA binding multicellular organism growth miRNA loading onto RISC involved in gene silencing by miRNA identical protein binding protein homodimerization activity skeletal muscle tissue regeneration positive regulation of viral genome replication positive regulation of translation regulation of viral transcription protein N-terminus binding perinuclear region of cytoplasm negative regulation of defense response to virus by host positive regulation of muscle cell differentiation neural precursor cell proliferation RISC-loading complex pre-miRNA binding regulation of production of siRNA involved in RNA interference regulation of production of miRNAs involved in gene silencing by miRNA uc007xwf.1 uc007xwf.2 uc007xwf.3 uc007xwf.4 uc007xwf.5 
ENSMUST00000023814.9 Npff ENSMUST00000023814.9 neuropeptide FF-amide peptide precursor (from RefSeq NM_018787.1) ENSMUST00000023814.1 ENSMUST00000023814.2 ENSMUST00000023814.3 ENSMUST00000023814.4 ENSMUST00000023814.5 ENSMUST00000023814.6 ENSMUST00000023814.7 ENSMUST00000023814.8 NM_018787 NPFF_MOUSE Q9WVA8 uc007xwj.1 uc007xwj.2 This gene encodes neuropeptides involved in analgesia, cardiovascular regulation, neuroendocrine function and opiate addiction. The encoded protein is a preproprotein that undergoes further processing to generate multiple amidated peptides. [provided by RefSeq, Jul 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF148701.1, SRR1660815.21063.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. Secreted. Belongs to the FARP (FMRFamide related peptide) family. G-protein coupled receptor binding acute inflammatory response to antigenic stimulus regulation of membrane depolarization receptor binding neuropeptide hormone activity extracellular region extracellular space positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway negative regulation of heart rate spinal cord development vasopressin secretion dendrite vesicle negative regulation of appetite response to drug perikaryon response to morphine axon terminus positive regulation of blood pressure negative regulation of insulin secretion regulation of sensory perception of pain excitatory postsynaptic potential maternal process involved in female pregnancy somatostatin secretion postsynapse uc007xwj.1 uc007xwj.2 
ENSMUST00000023818.11 Calcoco1 ENSMUST00000023818.11 calcium binding and coiled coil domain 1 (from RefSeq NM_026192.3) CACO1_MOUSE CocoA ENSMUST00000023818.1 ENSMUST00000023818.10 ENSMUST00000023818.2 ENSMUST00000023818.3 ENSMUST00000023818.4 ENSMUST00000023818.5 ENSMUST00000023818.6 ENSMUST00000023818.7 ENSMUST00000023818.8 ENSMUST00000023818.9 Kiaa1536 NM_026192 Q5DTX0 Q8CGU1 Q9D935 uc007xws.1 uc007xws.2 uc007xws.3 Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N- terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER- activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma- globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM (By similarity). Interacts with the bHLH-PAS domains of GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300. Interacts with CCAR1 (via N-terminus) and GATA1. Q8CGU1; O42486: Bcat; Xeno; NbExp=4; IntAct=EBI-972374, EBI-972394; Cytoplasm Nucleus Note=Shuttles between nucleus and cytoplasm. Expressed in all tissues examined except spleen, with high levels of expression in the heart and kidney. The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor. The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation. Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators. Belongs to the CALCOCO family. Sequence=BAD90452.1; Type=Erroneous initiation; Evidence=; nuclear chromatin RNA polymerase II distal enhancer sequence-specific DNA binding chromatin binding transcription cofactor activity transcription coactivator activity protein binding nucleus cytoplasm cytosol signal transduction beta-catenin binding protein C-terminus binding positive regulation of gene expression Wnt signaling pathway ligand-dependent nuclear receptor transcription coactivator activity intracellular steroid hormone receptor signaling pathway intracellular membrane-bounded organelle sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter armadillo repeat domain binding uc007xws.1 uc007xws.2 uc007xws.3 
ENSMUST00000023820.6 Fabp2 ENSMUST00000023820.6 fatty acid binding protein 2, intestinal (from RefSeq NM_007980.3) ENSMUST00000023820.1 ENSMUST00000023820.2 ENSMUST00000023820.3 ENSMUST00000023820.4 ENSMUST00000023820.5 Fabp2 NM_007980 Q53YP5 Q53YP5_MOUSE uc008rex.1 uc008rex.2 uc008rex.3 The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within enterocytes, possibly to sense lipids as part of energy homeostasis. In humans polymorphisms are associated with increased fat oxidation and insulin resistance. In mice deficiency of this gene alters body weight in a gender-specific manner and causes hyperinsulinemia. [provided by RefSeq, Jan 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY707992.1, BB610447.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. Cytoplasm Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. fatty acid binding lipid binding long-chain fatty acid binding intestinal lipid absorption uc008rex.1 uc008rex.2 uc008rex.3 
ENSMUST00000023826.5 Sncg ENSMUST00000023826.5 synuclein, gamma (from RefSeq NM_011430.3) ENSMUST00000023826.1 ENSMUST00000023826.2 ENSMUST00000023826.3 ENSMUST00000023826.4 NM_011430 Persyn Q9Z0F7 SYUG_MOUSE uc007tau.1 uc007tau.2 uc007tau.3 uc007tau.4 Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation. Cytoplasm, perinuclear region Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle (By similarity). Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. Expressed predominantly in the cell bodies and axons of primary sensory neurons, sympathetic neurons and motoneurons. Developmentally expressed in primary sensory neurons and motoneurons. In trigeminal ganglia, expression increases between embryonic day 10 and day 12. High levels are maintained here throughout later stages of development and in adulthood. Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases (By similarity). Simultaneous knockout of SNCA, SNCB and SNCG exhibit an age-dependent decrease in SNARE-complex assembly. Thus, synucleins are required for maintaining normal SNARE-complex assembly during aging in mice. Belongs to the synuclein family. protein binding cytoplasm microtubule organizing center spindle cytoskeleton plasma membrane chemical synaptic transmission adult locomotory behavior protein secretion regulation of dopamine secretion axon alpha-tubulin binding neuronal cell body axon terminus regulation of neurotransmitter secretion perinuclear region of cytoplasm beta-tubulin binding synapse organization negative regulation of neuron death uc007tau.1 uc007tau.2 uc007tau.3 uc007tau.4 
ENSMUST00000023828.9 Rttn ENSMUST00000023828.9 rotatin (from RefSeq NM_175542.3) A0PJL2 ENSMUST00000023828.1 ENSMUST00000023828.2 ENSMUST00000023828.3 ENSMUST00000023828.4 ENSMUST00000023828.5 ENSMUST00000023828.6 ENSMUST00000023828.7 ENSMUST00000023828.8 NM_175542 Q8BPW5 Q8C461 Q8CCK5 Q8CIG4 Q8R4Y8 RTTN_MOUSE Rttn uc008fvj.1 uc008fvj.2 uc008fvj.3 uc008fvj.4 Involved in the genetic cascade that governs left-right specification. Required for correct asymmetric expression of NODAL, LEFTY and PITX2 (By similarity). Interacts with PPP1R35; this interaction allows the mutual recruitment to the centriole. Cytoplasm, cytoskeleton, cilium basal body Note=Colocalizes with the basal bodies at the primary cilium. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8R4Y8-1; Sequence=Displayed; Name=2; IsoId=Q8R4Y8-2; Sequence=VSP_029034, VSP_029035; Name=3; IsoId=Q8R4Y8-3; Sequence=VSP_029032, VSP_029038, VSP_029039; Name=4; IsoId=Q8R4Y8-4; Sequence=VSP_029033, VSP_029036, VSP_029037; Expressed at 7.5 dpc. At 8.5 dpc, expressed in telencephalon and somites. At 9.5 dpc, expressed in somites, forelimb bud, basal forebrain and first branchial arch. At 11.5 dpc, expressed in heart primordium and branchial arches. Death at 11.5 dpc due to major developmental defects, including notochord degeneration, imperfect differentiation of somites and neural tube, axial rotation failure and randomized heart looping. Belongs to the rotatin family. Sequence=AAH23916.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cytoplasm centrosome centriole cytoskeleton cilium centriole replication multicellular organism development determination of left/right symmetry centriole-centriole cohesion integral component of membrane ciliary basal body organization ciliary basal body cell projection cilium organization uc008fvj.1 uc008fvj.2 uc008fvj.3 uc008fvj.4 
ENSMUST00000023830.16 Nus1 ENSMUST00000023830.16 NUS1 dehydrodolichyl diphosphate synthase subunit (from RefSeq NM_030250.2) D10Ertd438e ENSMUST00000023830.1 ENSMUST00000023830.10 ENSMUST00000023830.11 ENSMUST00000023830.12 ENSMUST00000023830.13 ENSMUST00000023830.14 ENSMUST00000023830.15 ENSMUST00000023830.2 ENSMUST00000023830.3 ENSMUST00000023830.4 ENSMUST00000023830.5 ENSMUST00000023830.6 ENSMUST00000023830.7 ENSMUST00000023830.8 ENSMUST00000023830.9 NGBR_MOUSE NM_030250 Ngbr Nus1 Q0P6D7 Q3TIA3 Q3TIR7 Q3U1Z4 Q99LJ8 uc007fbi.1 uc007fbi.2 uc007fbi.3 uc007fbi.4 With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. Reaction=(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = di- trans,poly-cis-polyprenyl diphosphate + n diphosphate; Xref=Rhea:RHEA:53008, Rhea:RHEA-COMP:13431, ChEBI:CHEBI:33019, ChEBI:CHEBI:128769, ChEBI:CHEBI:136960, ChEBI:CHEBI:175763; EC=2.5.1.87; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Protein modification; protein glycosylation. Lipid metabolism. Forms an active dehydrodolichyl diphosphate synthase complex with DHDDS. Interacts with NPC2. Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. Highly expressed in heart, liver, kidney and pancreas. Contains the RXG motif, which is important for substrate binding and prenyltransferase activity. The catalytic site at NUS1- DHDDS interface accomodates both the allylic and the homoallylic IPP substrates to the S1 and S2 pockets respectively. The beta-phosphate groups of IPP substrates form hydrogen bonds with the RXG motif of NUS1 and conserved residues of DHDDS (Arg-85, Arg-205, Arg-211 and Ser-213), while the allylic isopentenyl group is pointed toward the hydrophobic tunnel of the S1 pocket where the product elongation occurs. Leads to early embryonic lethality in vivo and defective cis-prenyltransferase activity and cholesterol levels in isolated fibroblasts. NUS1 seems to exist in two topological orientations, a minor glycosylated species with its C-terminus oriented towards the lumen regulating NPC2 stability, and a major fraction oriented with its C-terminus directed towards the cytosol where it regulates cis-IPTase activity. Belongs to the UPP synthase family. Sequence=AAH18372.1; Type=Frameshift; Evidence=; Sequence=BAE33349.1; Type=Frameshift; Evidence=; angiogenesis prenyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation dolichyl diphosphate biosynthetic process lipid metabolic process multicellular organism development membrane integral component of membrane transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups dolichol biosynthetic process cell differentiation regulation of intracellular cholesterol transport protein mannosylation vascular endothelial growth factor signaling pathway cholesterol homeostasis positive regulation of blood vessel endothelial cell migration dehydrodolichyl diphosphate synthase activity positive regulation of nitric-oxide synthase activity sterol homeostasis dehydrodolichyl diphosphate synthase complex uc007fbi.1 uc007fbi.2 uc007fbi.3 uc007fbi.4 
ENSMUST00000023832.7 Rgn ENSMUST00000023832.7 regucalcin, transcript variant 1 (from RefSeq NM_009060.3) A2AFC8 ENSMUST00000023832.1 ENSMUST00000023832.2 ENSMUST00000023832.3 ENSMUST00000023832.4 ENSMUST00000023832.5 ENSMUST00000023832.6 NM_009060 Q3UJG3 Q60944 Q64374 RGN_MOUSE Smp30 uc009std.1 uc009std.2 uc009std.3 Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). Reaction=D-glucono-1,5-lactone + H2O = D-gluconate + H(+); Xref=Rhea:RHEA:10440, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16217, ChEBI:CHEBI:18391; EC=3.1.1.17; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 divalent metal cation per subunit. Most active with Zn(2+) and Mn(2+) ions. The physiological cofactor is most likely Ca(2+) or Mg(2+). ; Cofactor biosynthesis; L-ascorbate biosynthesis via UDP-alpha- D-glucuronate pathway; L-ascorbate from UDP-alpha-D-glucuronate: step 3/4. Monomer. Cytoplasm. Mainly present in the liver. Weak expression was found in the brain, lung and kidney. Protein amounts in liver decrease significantly with age. By calcium. Mice do not thrive after weaning when kept on a vitamin C-less diet. They develop scurvy, have reduced bone mineral density and brittle bones. Hepatocytes exhibit accumulation of lipid droplets. Mice display increased mortality after about 3 months, and their life span is shorter than normal. Belongs to the SMP-30/CGR1 family. kidney development liver development negative regulation of protein phosphorylation gluconolactonase activity calcium ion binding nucleus cytoplasm cytosol negative regulation of protein kinase activity cellular calcium ion homeostasis spermatogenesis aging zinc ion binding positive regulation of triglyceride biosynthetic process positive regulation of glucose metabolic process positive regulation of phosphatase activity hydrolase activity L-ascorbic acid biosynthetic process enzyme regulator activity negative regulation of phosphoprotein phosphatase activity positive regulation of ATPase activity negative regulation of GTPase activity negative regulation of apoptotic process positive regulation of GTPase activity negative regulation of nitric oxide biosynthetic process positive regulation of fatty acid biosynthetic process metal ion binding negative regulation of epithelial cell proliferation regulation of calcium-mediated signaling negative regulation of cyclic-nucleotide phosphodiesterase activity liver regeneration negative regulation of flagellated sperm motility positive regulation of superoxide dismutase activity positive regulation of calcium-transporting ATPase activity negative regulation of RNA biosynthetic process negative regulation of bone development positive regulation of proteolysis involved in cellular protein catabolic process negative regulation of calcium-dependent ATPase activity negative regulation of DNA catabolic process positive regulation of dUTP diphosphatase activity negative regulation of leucine-tRNA ligase activity negative regulation of DNA biosynthetic process uc009std.1 uc009std.2 uc009std.3 
ENSMUST00000023835.3 Slc10a2 ENSMUST00000023835.3 solute carrier family 10, member 2 (from RefSeq NM_011388.3) ENSMUST00000023835.1 ENSMUST00000023835.2 NM_011388 Q0VBB8 Q0VBB8_MOUSE Slc10a2 uc009kub.1 uc009kub.2 uc009kub.3 uc009kub.4 Reaction=2 Na(+)(out) + tauro-beta-muricholate(out) = 2 Na(+)(in) + tauro-beta-muricholate(in); Xref=Rhea:RHEA:72179, ChEBI:CHEBI:29101, ChEBI:CHEBI:133064; Evidence=; Reaction=2 Na(+)(out) + tauroallocholate(out) = 2 Na(+)(in) + tauroallocholate(in); Xref=Rhea:RHEA:51840, ChEBI:CHEBI:29101, ChEBI:CHEBI:191406; Evidence=; Reaction=2 Na(+)(out) + taurochenodeoxycholate(out) = 2 Na(+)(in) + taurochenodeoxycholate(in); Xref=Rhea:RHEA:71923, ChEBI:CHEBI:9407, ChEBI:CHEBI:29101; Evidence=; Reaction=2 Na(+)(out) + taurocholate(out) = 2 Na(+)(in) + taurocholate(in); Xref=Rhea:RHEA:71875, ChEBI:CHEBI:29101, ChEBI:CHEBI:36257; Evidence=; Reaction=2 Na(+)(out) + taurodeoxycholate(out) = 2 Na(+)(in) + taurodeoxycholate(in); Xref=Rhea:RHEA:72087, ChEBI:CHEBI:29101, ChEBI:CHEBI:36261; Evidence=; Reaction=2 Na(+)(out) + tauronorcholate(out) = 2 Na(+)(in) + tauronorcholate(in); Xref=Rhea:RHEA:71915, ChEBI:CHEBI:29101, ChEBI:CHEBI:191405; Evidence=; Reaction=2 Na(+)(out) + tauroursodeoxycholate(out) = 2 Na(+)(in) + tauroursodeoxycholate(in); Xref=Rhea:RHEA:71927, ChEBI:CHEBI:29101, ChEBI:CHEBI:132028; Evidence=; Reaction=cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71911, ChEBI:CHEBI:29101, ChEBI:CHEBI:29747; Evidence=; Reaction=glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71935, ChEBI:CHEBI:29101, ChEBI:CHEBI:29746; Evidence=; Monomer and homodimer. Membrane ; Multi- pass membrane protein Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. bile acid:sodium symporter activity bile acid and bile salt transport membrane integral component of membrane apical plasma membrane uc009kub.1 uc009kub.2 uc009kub.3 uc009kub.4 
ENSMUST00000023836.4 Mospd1 ENSMUST00000023836.4 motile sperm domain containing 1, transcript variant 1 (from RefSeq NM_027409.5) ENSMUST00000023836.1 ENSMUST00000023836.2 ENSMUST00000023836.3 MSPD1_MOUSE NM_027409 Q497P5 Q8VEL0 Q9D8Y9 uc009tfa.1 uc009tfa.2 uc009tfa.3 uc009tfa.4 Plays a role in differentiation and/or proliferation of mesenchymal stem cells (PubMed:21792907, PubMed:26175344). Proposed to be involved in epithelial-to-mesenchymal transition (EMT) (PubMed:21792907). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation (PubMed:26175344). Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VEL0-1; Sequence=Displayed; Name=2; IsoId=Q8VEL0-2; Sequence=VSP_014045; Widely expressed. Shows highest expression in ribs, and slightly lower levels of expression in heart, kidney, muscle, thymus, calvariae and lung. Also detected at low levels in spleen and liver. Expressed at low levels in undifferentiated mesenchymal stem cells and then shows increasing expression levels as differentiation proceeds. May be up-regulated in response to cell-cell contact. negative regulation of transcription from RNA polymerase II promoter Golgi membrane molecular_function nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus membrane integral component of membrane cell differentiation positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm uc009tfa.1 uc009tfa.2 uc009tfa.3 uc009tfa.4 
ENSMUST00000023840.7 Cxcl13 ENSMUST00000023840.7 C-X-C motif chemokine ligand 13 (from RefSeq NM_018866.3) Cxcl13 ENSMUST00000023840.1 ENSMUST00000023840.2 ENSMUST00000023840.3 ENSMUST00000023840.4 ENSMUST00000023840.5 ENSMUST00000023840.6 NM_018866 Q3U1E8 Q3U1E8_MOUSE uc008yfb.1 uc008yfb.2 uc008yfb.3 Secreted Belongs to the intercrine alpha (chemokine CxC) family. cytokine activity extracellular region extracellular space chemotaxis defense response immune response signal transduction chemokine activity cell chemotaxis uc008yfb.1 uc008yfb.2 uc008yfb.3 
ENSMUST00000023845.7 H2-M10.2 ENSMUST00000023845.7 histocompatibility 2, M region locus 10.2 (from RefSeq NM_177923.1) ENSMUST00000023845.1 ENSMUST00000023845.2 ENSMUST00000023845.3 ENSMUST00000023845.4 ENSMUST00000023845.5 ENSMUST00000023845.6 H2-M10.2 NM_177923 Q85ZW9 Q85ZW9_MOUSE uc012asu.1 uc012asu.2 uc012asu.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc012asu.1 uc012asu.2 uc012asu.3 
ENSMUST00000023846.11 Lrrc71 ENSMUST00000023846.11 leucine rich repeat containing 71 (from RefSeq NM_028971.1) ENSMUST00000023846.1 ENSMUST00000023846.10 ENSMUST00000023846.2 ENSMUST00000023846.3 ENSMUST00000023846.4 ENSMUST00000023846.5 ENSMUST00000023846.6 ENSMUST00000023846.7 ENSMUST00000023846.8 ENSMUST00000023846.9 LRC71_MOUSE NM_028971 Q8C0S9 Q9D3W5 uc008psp.1 uc008psp.2 uc008psp.3 Sequence=BAC26688.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; molecular_function cellular_component biological_process uc008psp.1 uc008psp.2 uc008psp.3 
ENSMUST00000023851.9 Ndufa5 ENSMUST00000023851.9 NADH:ubiquinone oxidoreductase subunit A5, transcript variant 1 (from RefSeq NM_026614.3) ENSMUST00000023851.1 ENSMUST00000023851.2 ENSMUST00000023851.3 ENSMUST00000023851.4 ENSMUST00000023851.5 ENSMUST00000023851.6 ENSMUST00000023851.7 ENSMUST00000023851.8 NDUA5_MOUSE NM_026614 Q9CPP6 Q9CY90 Q9D2P2 Q9D703 Q9D739 uc009bbs.1 uc009bbs.2 uc009bbs.3 uc009bbs.4 uc009bbs.5 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Acetylation of Lys-98 is observed in liver mitochondria from fasted mice but not from fed mice. Lethality around embryonic day 9 (E9). Conditional knockout in the central nervous system does not lead to any visible phenotype until mice reach 10-11 months of age: then mice become lethargic, lose motor control and have difficulty maintaining balance. Defects cause loss of other complex I subunits and reduced NADH dehydrogenase activity. Belongs to the complex I NDUFA5 subunit family. mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I NADH dehydrogenase (ubiquinone) activity membrane respiratory electron transport chain mitochondrial respiratory chain complex I assembly macromolecular complex respiratory chain complex I oxidation-reduction process respiratory chain uc009bbs.1 uc009bbs.2 uc009bbs.3 uc009bbs.4 uc009bbs.5 
ENSMUST00000023856.9 Msrb2 ENSMUST00000023856.9 methionine sulfoxide reductase B2 (from RefSeq NM_029619.2) ENSMUST00000023856.1 ENSMUST00000023856.2 ENSMUST00000023856.3 ENSMUST00000023856.4 ENSMUST00000023856.5 ENSMUST00000023856.6 ENSMUST00000023856.7 ENSMUST00000023856.8 MSRB2_MOUSE NM_029619 Q78J03 uc008imf.1 uc008imf.2 uc008imf.3 uc008imf.4 uc008imf.5 Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. Reaction=[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]; Xref=Rhea:RHEA:24164, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12314, ChEBI:CHEBI:15377, ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:45764, ChEBI:CHEBI:50058; EC=1.8.4.12; Evidence=; Reaction=[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]- dithiol + L-methionine (R)-S-oxide; Xref=Rhea:RHEA:21260, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57844, ChEBI:CHEBI:58773; EC=1.8.4.14; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Inhibited by high concentrations of substrate. Mitochondrion Belongs to the MsrB Met sulfoxide reductase family. actin binding mitochondrion response to oxidative stress zinc ion binding oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor actin filament polymerization protein repair peptide-methionine (R)-S-oxide reductase activity L-methionine-(R)-S-oxide reductase activity metal ion binding oxidation-reduction process uc008imf.1 uc008imf.2 uc008imf.3 uc008imf.4 uc008imf.5 
ENSMUST00000023861.5 Serpinb3d ENSMUST00000023861.5 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D (from RefSeq NM_201376.1) ENSMUST00000023861.1 ENSMUST00000023861.2 ENSMUST00000023861.3 ENSMUST00000023861.4 NM_201376 Q6UKZ0 Q6UKZ0_MOUSE Serpinb3d uc007chh.1 uc007chh.2 uc007chh.3 Belongs to the serpin family. Ov-serpin subfamily. virus receptor activity protease binding serine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular space nucleus cytoplasm positive regulation of cell proliferation negative regulation of peptidase activity positive regulation of epithelial to mesenchymal transition positive regulation of endopeptidase activity negative regulation of endopeptidase activity positive regulation of cell migration cytoplasmic vesicle autocrine signaling paracrine signaling negative regulation of catalytic activity negative regulation of JUN kinase activity negative regulation of proteolysis viral entry into host cell extracellular exosome uc007chh.1 uc007chh.2 uc007chh.3 
ENSMUST00000023867.8 Rfc2 ENSMUST00000023867.8 replication factor C (activator 1) 2 (from RefSeq NM_020022.2) ENSMUST00000023867.1 ENSMUST00000023867.2 ENSMUST00000023867.3 ENSMUST00000023867.4 ENSMUST00000023867.5 ENSMUST00000023867.6 ENSMUST00000023867.7 NM_020022 Q9WUK4 RFC2_MOUSE uc008zwl.1 uc008zwl.2 uc008zwl.3 The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA. RFC2 also interacts with PRKAR1A; the complex may be involved in cell survival. Interacts with DDX11. Nucleus Belongs to the activator 1 small subunits family. nucleotide binding DNA binding DNA clamp loader activity ATP binding nucleus DNA replication factor C complex DNA replication DNA-dependent DNA replication single-stranded DNA-dependent ATP-dependent DNA helicase activity enzyme binding Ctf18 RFC-like complex DNA duplex unwinding positive regulation of DNA-directed DNA polymerase activity uc008zwl.1 uc008zwl.2 uc008zwl.3 
ENSMUST00000023869.15 Denr ENSMUST00000023869.15 density-regulated protein, transcript variant 1 (from RefSeq NM_026603.5) DENR_MOUSE ENSMUST00000023869.1 ENSMUST00000023869.10 ENSMUST00000023869.11 ENSMUST00000023869.12 ENSMUST00000023869.13 ENSMUST00000023869.14 ENSMUST00000023869.2 ENSMUST00000023869.3 ENSMUST00000023869.4 ENSMUST00000023869.5 ENSMUST00000023869.6 ENSMUST00000023869.7 ENSMUST00000023869.8 ENSMUST00000023869.9 NM_026603 Q3UXY1 Q9CQJ6 uc008zor.1 uc008zor.2 uc008zor.3 May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity). Interacts with MCTS1. Belongs to the DENR family. formation of translation preinitiation complex translation reinitiation mRNA binding translation initiation factor activity translation translational initiation ribosome disassembly IRES-dependent viral translational initiation uc008zor.1 uc008zor.2 uc008zor.3 
ENSMUST00000023873.12 Prmt5 ENSMUST00000023873.12 protein arginine N-methyltransferase 5, transcript variant 1 (from RefSeq NM_013768.3) A0A0R4J049 A0A0R4J049_MOUSE ENSMUST00000023873.1 ENSMUST00000023873.10 ENSMUST00000023873.11 ENSMUST00000023873.2 ENSMUST00000023873.3 ENSMUST00000023873.4 ENSMUST00000023873.5 ENSMUST00000023873.6 ENSMUST00000023873.7 ENSMUST00000023873.8 ENSMUST00000023873.9 NM_013768 Prmt5 uc007twf.1 uc007twf.2 uc007twf.3 uc007twf.4 This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation and the assembly of small nuclear ribonucleoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:48108, Rhea:RHEA-COMP:10532, Rhea:RHEA- COMP:11992, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:88221; EC=2.1.1.320; Evidence= Cytoplasm Nucleus Belongs to the class I-like SAM-binding methyltransferase superfamily. spliceosomal snRNP assembly p53 binding nucleus cytoplasm Golgi apparatus cytosol DNA-templated transcription, termination protein methylation methyltransferase activity methyl-CpG binding histone-arginine N-methyltransferase activity protein-arginine N-methyltransferase activity transferase activity peptidyl-arginine methylation peptidyl-arginine methylation, to symmetrical-dimethyl arginine methylation macromolecular complex methylosome histone arginine methylation histone methyltransferase complex protein-arginine omega-N symmetric methyltransferase activity peptidyl-arginine N-methylation endothelial cell activation identical protein binding ribonucleoprotein complex binding histone H4-R3 methylation histone methyltransferase activity (H4-R3 specific) regulation of DNA methylation macromolecular complex binding negative regulation of cell differentiation protein heterodimerization activity positive regulation of oligodendrocyte differentiation regulation of ERK1 and ERK2 cascade Golgi ribbon formation liver regeneration positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway uc007twf.1 uc007twf.2 uc007twf.3 uc007twf.4 
ENSMUST00000023882.14 Sympk ENSMUST00000023882.14 symplekin, transcript variant 1 (from RefSeq NM_026605.3) ENSMUST00000023882.1 ENSMUST00000023882.10 ENSMUST00000023882.11 ENSMUST00000023882.12 ENSMUST00000023882.13 ENSMUST00000023882.2 ENSMUST00000023882.3 ENSMUST00000023882.4 ENSMUST00000023882.5 ENSMUST00000023882.6 ENSMUST00000023882.7 ENSMUST00000023882.8 ENSMUST00000023882.9 F8WJD4 NM_026605 Q80X82 SYMPK_MOUSE uc009fkh.1 uc009fkh.2 uc009fkh.3 uc009fkh.4 Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity (By similarity). Found in a heat-sensitive complex at least composed of several cleavage and polyadenylation specific and cleavage stimulation factors. Interacts with CPSF2, CPSF3 and CSTF2. Interacts (via N-terminus) with HSF1; this interaction is direct and occurs upon heat shock. Interacts with SSU72. Cytoplasm, cytoskeleton Cell junction, tight junction Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell junction Nucleus, nucleoplasm Note=Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells. Colocalizes with HSF1 in nuclear stress bodies upon heat shock. The HEAT repeats have been determined based on 3D-structure analysis of the D.melanogaster ortholog and are not detected by sequence-based prediction programs. Belongs to the Symplekin family. molecular_function nucleus nucleoplasm cytoplasm cytosol cytoskeleton plasma membrane bicellular tight junction mRNA polyadenylation mRNA processing cell adhesion membrane nuclear body cell junction negative regulation of protein binding positive regulation of protein dephosphorylation nuclear stress granule uc009fkh.1 uc009fkh.2 uc009fkh.3 uc009fkh.4 
ENSMUST00000023884.7 Ldc1 ENSMUST00000023884.7 leucine decarboxylase 1 (from RefSeq NM_001034872.2) A3KFW3 ENSMUST00000023884.1 ENSMUST00000023884.2 ENSMUST00000023884.3 ENSMUST00000023884.4 ENSMUST00000023884.5 ENSMUST00000023884.6 Gm853 Ldc1 NM_001034872 Q3UNZ2 Q3UNZ2_MOUSE uc008uzb.1 uc008uzb.2 uc008uzb.3 Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Belongs to the Orn/Lys/Arg decarboxylase class-II family. catalytic activity cytoplasm polyamine biosynthetic process putrescine biosynthetic process from ornithine ornithine decarboxylase activator activity positive regulation of catalytic activity ornithine decarboxylase activity uc008uzb.1 uc008uzb.2 uc008uzb.3 
ENSMUST00000023886.7 Sult1c2 ENSMUST00000023886.7 sulfotransferase family, cytosolic, 1C, member 2 (from RefSeq NM_026935.4) ENSMUST00000023886.1 ENSMUST00000023886.2 ENSMUST00000023886.3 ENSMUST00000023886.4 ENSMUST00000023886.5 ENSMUST00000023886.6 NM_026935 Q3UNA9 Q8R210 Q9D939 ST1C2_MOUSE Sult1c1 uc008czu.1 uc008czu.2 uc008czu.3 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds (PubMed:12164856). Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed:12164856). Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity). Reaction=3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'- bisphosphate + an aryl sulfate + H(+); Xref=Rhea:RHEA:12164, ChEBI:CHEBI:15378, ChEBI:CHEBI:33853, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:140317; EC=2.8.2.1; Evidence=; Kinetic parameters: KM=3.1 mM for p-nitrophenol ; Vmax=20 nmol/min/mg enzyme with p-nitrophenol as substrate ; Cytoplasm Lysosome Highly expressed in stomach and kidney. Belongs to the sulfotransferase 1 family. lysosome sulfotransferase activity transferase activity sulfation uc008czu.1 uc008czu.2 uc008czu.3 
ENSMUST00000023897.7 Gzma ENSMUST00000023897.7 granzyme A (from RefSeq NM_010370.3) ENSMUST00000023897.1 ENSMUST00000023897.2 ENSMUST00000023897.3 ENSMUST00000023897.4 ENSMUST00000023897.5 ENSMUST00000023897.6 Gzma NM_010370 Q3U0N0 Q3U0N0_MOUSE uc007rxc.1 uc007rxc.2 serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity negative regulation of endodeoxyribonuclease activity protein homodimerization activity positive regulation of apoptotic process negative regulation of DNA binding negative regulation of oxidoreductase activity proteolysis involved in cellular protein catabolic process uc007rxc.1 uc007rxc.2 
ENSMUST00000023906.4 Reg2 ENSMUST00000023906.4 regenerating islet-derived 2 (from RefSeq NM_009043.2) ENSMUST00000023906.1 ENSMUST00000023906.2 ENSMUST00000023906.3 NM_009043 Q545J0 Q545J0_MOUSE Reg2 uc009cjz.1 uc009cjz.2 uc009cjz.3 carbohydrate binding uc009cjz.1 uc009cjz.2 uc009cjz.3 
ENSMUST00000023911.11 Nagpa ENSMUST00000023911.11 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, transcript variant 1 (from RefSeq NM_013796.3) ENSMUST00000023911.1 ENSMUST00000023911.10 ENSMUST00000023911.2 ENSMUST00000023911.3 ENSMUST00000023911.4 ENSMUST00000023911.5 ENSMUST00000023911.6 ENSMUST00000023911.7 ENSMUST00000023911.8 ENSMUST00000023911.9 NAGPA_MOUSE NM_013796 Q3UUT5 Q8BJ48 Q8CHQ8 Q9QZE6 uc007ybw.1 uc007ybw.2 uc007ybw.3 uc007ybw.4 Catalyzes the second step in the formation of the mannose 6- phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. Reaction=H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha- D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] = H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl- (glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine; Xref=Rhea:RHEA:24372, Rhea:RHEA-COMP:14508, Rhea:RHEA-COMP:14509, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:140369, ChEBI:CHEBI:140371, ChEBI:CHEBI:506227; EC=3.1.4.45; Protein modification; protein glycosylation. Homotetramer arranged as two disulfide-linked homodimers. Interacts with AP4M1. Golgi apparatus, Golgi stack membrane; Single- pass type I membrane protein. Golgi apparatus, trans-Golgi network Note=Cis/medial Golgi. The tyrosine-based internalization signal may be essential for its retrieval from the plasma membrane to the TGN. The C-terminal NPFKD sequence is an attractive candidate for either an endocytosis signal acting at the plasma membrane or a retrieval signal acting at the TGN to return the enzyme to the cis/medial-Golgi. The precursor is cleaved and activated in the trans-Golgi network by a furin endopeptidase. N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity Golgi apparatus protein glycosylation membrane integral component of membrane hydrolase activity Golgi cisterna membrane secretion of lysosomal enzymes uc007ybw.1 uc007ybw.2 uc007ybw.3 uc007ybw.4 
ENSMUST00000023913.11 Get1 ENSMUST00000023913.11 guided entry of tail-anchored proteins factor 1 (from RefSeq NM_207301.3) ENSMUST00000023913.1 ENSMUST00000023913.10 ENSMUST00000023913.2 ENSMUST00000023913.3 ENSMUST00000023913.4 ENSMUST00000023913.5 ENSMUST00000023913.6 ENSMUST00000023913.7 ENSMUST00000023913.8 ENSMUST00000023913.9 GET1_MOUSE Get1 NM_207301 Q3TA55 Q8K0D7 Q9D1W0 Wrb uc008acq.1 uc008acq.2 uc008acq.3 Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, CAMLG/GET2 and GET3. Within the complex, GET1 and CAMLG form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer. Interacts with CAMLG/GET2 (via C-terminus). GET3 shows a higher affinity for CAMLG than for GET1. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the WRB/GET1 family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane tail-anchored membrane protein insertion into ER membrane uc008acq.1 uc008acq.2 uc008acq.3 
ENSMUST00000023917.8 Lrrc69 ENSMUST00000023917.8 Belongs to the LRRC69 family. (from UniProt Q9D9Q0) AK006601 ENSMUST00000023917.1 ENSMUST00000023917.2 ENSMUST00000023917.3 ENSMUST00000023917.4 ENSMUST00000023917.5 ENSMUST00000023917.6 ENSMUST00000023917.7 LRC69_MOUSE Q9D9Q0 uc008sba.1 uc008sba.2 uc008sba.3 Belongs to the LRRC69 family. molecular_function cellular_component biological_process uc008sba.1 uc008sba.2 uc008sba.3 
ENSMUST00000023918.13 Ivns1abp ENSMUST00000023918.13 influenza virus NS1A binding protein, transcript variant 2 (from RefSeq NM_054102.2) ENSMUST00000023918.1 ENSMUST00000023918.10 ENSMUST00000023918.11 ENSMUST00000023918.12 ENSMUST00000023918.2 ENSMUST00000023918.3 ENSMUST00000023918.4 ENSMUST00000023918.5 ENSMUST00000023918.6 ENSMUST00000023918.7 ENSMUST00000023918.8 ENSMUST00000023918.9 Kiaa0850 NM_054102 NS1BP_MOUSE Nd1 Nd1L Nd1S Ns1 Ns1bp Q06BK6 Q3TXI1 Q3UJE3 Q3UJS1 Q3UKH9 Q3UMK9 Q6ZQ34 Q920Q8 Q99KN0 Q9D978 uc007cyn.1 uc007cyn.2 uc007cyn.3 Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (PubMed:12213805, PubMed:16317045). Protects cells from cell death induced by actin destabilization (PubMed:16952015). Functions as a modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (By similarity). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (By similarity). Inhibits pre-mRNA splicing (in vitro) (By similarity). [Isoform 2]: May play a role in cell cycle progression in the nucleus. Homodimer; through the BTB domain. Interacts with AHR/Aryl hydrocarbon receptor (By similarity). [Isoform 1]: Cytoplasm. Cytoplasm, cytoskeleton Note=Associated with actin filaments. [Isoform 2]: Nucleus Note=Not associated with actin filaments (PubMed:15684717). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Nd1-L; IsoId=Q920Q8-1; Sequence=Displayed; Name=2; Synonyms=Nd1-S; IsoId=Q920Q8-2; Sequence=VSP_024812, VSP_024813; Name=3; Synonyms=Nd1-L2; IsoId=Q920Q8-3; Sequence=VSP_024811; Name=4; IsoId=Q920Q8-4; Sequence=VSP_024810; Ubiquitous expression. In the heart, the highest expression is detected in the ventricles and the lowest in the atria. Expressed in dendrites and spines in neurons. Barely detected in the heart at 15.5 dpc, but clearly expressed in newborn heart with increased amount up to 8 weeks of age. Decreased expression in various organs and cultured cell lines by doxorubicin treatment which may reduce mRNA stability. When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the BTB domain inhibits AHR signaling induced by IVNS1ABP. Mice develop normally with no gross abnormalities. However, they display marked sensitivity to doxorubicin cardiotoxicity with increased number of cardiomyocytes apoptosis. Analysis of hearts from knockout mice reveal vacuolization and edema of cardiomaycytes. Transgenic mice overexpressing Ivns1abp develop normally with no gross abnormalities up to 7-month old. However, they display a marked resistance to the cardiotoxic effect of doxorubicin which is an anti-neoplastic agent known to affect actin skeleton and an effective drug for cancer therapy with cardiotoxicity as side effect. Overexpression of Ivns1abp in the heart protect cardiomyocytes from apoptosis and improved survival rate after doxorubicin injection. Disorganized actin skeleton is observed in cells transfected with isoform 2 (Nd1-S), which lacks the six kelch repeats. Sequence=BAC98039.1; Type=Erroneous initiation; Evidence=; protein binding nucleus cytoplasm cytosol cytoskeleton RNA splicing response to virus negative regulation of protein ubiquitination negative regulation of intrinsic apoptotic signaling pathway uc007cyn.1 uc007cyn.2 uc007cyn.3 
ENSMUST00000023924.4 Rpp14 ENSMUST00000023924.4 ribonuclease P 14 subunit (from RefSeq NM_025938.4) ENSMUST00000023924.1 ENSMUST00000023924.2 ENSMUST00000023924.3 NM_025938 Q9CQH8 RPP14_MOUSE uc007seq.1 uc007seq.2 uc007seq.3 uc007seq.4 Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Nucleus, nucleolus Belongs to the eukaryotic/archaeal RNase P protein component 2 family. tRNA 5'-leader removal ribonuclease P activity ribonuclease activity nucleus nucleolus tRNA processing hydrolase activity multimeric ribonuclease P complex ribonuclease P RNA binding RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc007seq.1 uc007seq.2 uc007seq.3 uc007seq.4 
ENSMUST00000023934.8 Hbb-bs ENSMUST00000023934.8 hemoglobin, beta adult s chain (from RefSeq NM_001201391.1) A8DUK4 A8DUK4_MOUSE ENSMUST00000023934.1 ENSMUST00000023934.2 ENSMUST00000023934.3 ENSMUST00000023934.4 ENSMUST00000023934.5 ENSMUST00000023934.6 ENSMUST00000023934.7 Glna1 Hbb-bs Hbb-bt Hbbt1 Hbbt2 NM_001201391 uc009iuq.1 uc009iuq.2 uc009iuq.3 uc009iuq.4 uc009iuq.5 uc009iuq.6 This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues. This gene is one of a cluster of beta-hemoglobin genes that are distally regulated by a locus control region, and which are organized along the chromosome in the order of their developmental expression. In mouse, two major strain-specific haplotypes of the beta-globin gene cluster are found - a 'single' haplotype found in C57BL/-type strains, which includes two highly similar adult beta-globin genes, beta s and beta t, and a 'diffuse' haplotype found in strains such as BALB/c and 129Sv, which includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This gene represents the beta s adult gene found in the 'single' haplotype. Primary chromosome 7 of the mouse reference genome assembly, which is derived from C57BL/6 strain mice, represents the 'single' haplotype, while the 'diffuse' haplotype is represented in the reference genome collection by the BALB/c strain alternate contig, NT_095534.1. [provided by RefSeq, May 2013]. Sequence Note: This RefSeq record was created from genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: This gene represents the first of two adult-expressed beta-globin genes in the 'single' haplotype of the beta-globin cluster (PMID:7237554). The 'single' haplotype is found in C57BL/-type strains and includes two highly similar adult beta-globin genes, beta s and beta t, while the 'diffuse' haplotype is found in strains such as BALB/c and 129Sv, and includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This CCDS is based on primary chromosome 7 of the mouse reference genome assembly, which represents the 'single' haplotype. ##Evidence-Data-START## Transcript exon combination :: AW547094.1, BU571325.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Involved in oxygen transport from the lung to the various peripheral tissues. Belongs to the globin family. oxygen transporter activity extracellular space hemoglobin complex oxygen transport oxygen binding heme binding hemoglobin binding hemoglobin alpha binding hemoglobin beta binding haptoglobin-hemoglobin complex hydrogen peroxide catabolic process organic acid binding metal ion binding cellular oxidant detoxification peroxidase activity haptoglobin binding uc009iuq.1 uc009iuq.2 uc009iuq.3 uc009iuq.4 uc009iuq.5 uc009iuq.6 
ENSMUST00000023952.10 Krt8 ENSMUST00000023952.10 keratin 8 (from RefSeq NM_031170.2) ENSMUST00000023952.1 ENSMUST00000023952.2 ENSMUST00000023952.3 ENSMUST00000023952.4 ENSMUST00000023952.5 ENSMUST00000023952.6 ENSMUST00000023952.7 ENSMUST00000023952.8 ENSMUST00000023952.9 K2C8_MOUSE Krt2-8 NM_031170 P11679 Q3KQK5 Q3TGI1 Q3TJE1 Q3TKY7 Q61463 Q61518 Q61519 uc007xui.1 uc007xui.2 uc007xui.3 Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Heterotetramer of two type I and two type II keratins (PubMed:24940650). Forms a heterodimer with KRT18 (PubMed:24940650). Associates with KRT20 (PubMed:12857878). Interacts with PLEC isoform 1C, when in a heterodimer with KRT18 (PubMed:24940650). Interacts with PNN (By similarity). When associated with KRT19, interacts with DMD. Interacts with TCHP (By similarity). Interacts with APEX1 (By similarity). Interacts with GPER1 (By similarity). Interacts with EPPK1 (PubMed:25617501). Interacts with PKP1 and PKP2 (By similarity). Cytoplasm Nucleus, nucleoplasm Nucleus matrix Expressed in abundance in the epithelia of colon, bladder, ileum, and stomach, with lower expression observed in earskin (at protein level). Also expressed in pancreas, liver, dudenum and jejunum. Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-80 phosphorylation plays an important role in keratin filament reorganization (By similarity). O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation (By similarity). O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. Sequence=AAA37551.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cell morphogenesis involved in differentiation protein binding nucleus nucleoplasm cytoplasm intermediate filament cell-cell junction multicellular organism development dystrophin-associated glycoprotein complex apicolateral plasma membrane nuclear matrix Z disc tumor necrosis factor-mediated signaling pathway sarcolemma costamere macromolecular complex binding keratin filament intermediate filament cytoskeleton sarcomere organization response to hydrostatic pressure response to other organism cell differentiation involved in embryonic placenta development cell periphery scaffold protein binding extrinsic apoptotic signaling pathway hepatocyte apoptotic process uc007xui.1 uc007xui.2 uc007xui.3 
ENSMUST00000023953.5 Ceacam14 ENSMUST00000023953.5 CEA cell adhesion molecule 14 (from RefSeq NM_025957.4) Ceacam14 ENSMUST00000023953.1 ENSMUST00000023953.2 ENSMUST00000023953.3 ENSMUST00000023953.4 NM_025957 Q78Y72 Q78Y72_MOUSE uc009fja.1 uc009fja.2 uc009fja.3 molecular_function cellular_component biological_process uc009fja.1 uc009fja.2 uc009fja.3 
ENSMUST00000023958.10 P3h3 ENSMUST00000023958.10 prolyl 3-hydroxylase 3, transcript variant 4 (from RefSeq NR_163806.1) ENSMUST00000023958.1 ENSMUST00000023958.2 ENSMUST00000023958.3 ENSMUST00000023958.4 ENSMUST00000023958.5 ENSMUST00000023958.6 ENSMUST00000023958.7 ENSMUST00000023958.8 ENSMUST00000023958.9 Leprel2 NR_163806 O88836 P3H3_MOUSE P3h3 Q8CG70 uc009dsf.1 uc009dsf.2 uc009dsf.3 Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (PubMed:27119146). Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea (PubMed:28115524). Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly (PubMed:27119146, PubMed:28115524). Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3- hydroxylases (PubMed:28115524). Reaction=2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]; Xref=Rhea:RHEA:22872, Rhea:RHEA- COMP:11676, Rhea:RHEA-COMP:11678, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50342, ChEBI:CHEBI:85428; EC=1.14.11.7; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Identified in a complex with PLOD1 and P3H4. Endoplasmic reticulum Detected in kidney (at protein level). No visible phenotype at birth. Lysine hydroxylation of skin and bone collagen alpha chains is strongly reduced. In contrast, prolyl 3-hydroxylation is not affected, possibly due to complementation by other family members. Dorsal skin displays impaired packing of collagen fibrils, decreased skin tensile strength, and increased skin fragility. Likewise, mice deficient for both P3h3 and P3h4 display decreased lysine hydroxylation of collagen alpha chains, but normal collagen prolyl 3-hydroxylation. Belongs to the leprecan family. iron ion binding protein binding endoplasmic reticulum negative regulation of cell proliferation oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen peptidyl-lysine hydroxylation peptidyl-proline hydroxylation procollagen-proline 3-dioxygenase activity L-ascorbic acid binding collagen metabolic process collagen biosynthetic process metal ion binding dioxygenase activity oxidation-reduction process catalytic complex uc009dsf.1 uc009dsf.2 uc009dsf.3 
ENSMUST00000023959.13 Grm2 ENSMUST00000023959.13 glutamate receptor, metabotropic 2 (from RefSeq NM_001160353.1) ENSMUST00000023959.1 ENSMUST00000023959.10 ENSMUST00000023959.11 ENSMUST00000023959.12 ENSMUST00000023959.2 ENSMUST00000023959.3 ENSMUST00000023959.4 ENSMUST00000023959.5 ENSMUST00000023959.6 ENSMUST00000023959.7 ENSMUST00000023959.8 ENSMUST00000023959.9 GRM2_MOUSE Gprc1b Mglur2 NM_001160353 Q14BI2 uc012gzy.1 uc012gzy.2 uc012gzy.3 uc012gzy.4 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Interacts with TAMALIN (By similarity). Interacts with HTR2A. Cell membrane; Multi-pass membrane protein. Synapse. Cell projection, dendrite. Detected in neurons in brain cortex (at protein level). Belongs to the G-protein coupled receptor 3 family. group II metabotropic glutamate receptor activity G-protein coupled receptor activity calcium channel regulator activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway chemical synaptic transmission glutamate receptor activity glutamate secretion membrane integral component of membrane cell junction axon dendrite presynaptic membrane cell projection neuron projection synapse regulation of synaptic transmission, glutamatergic glutamate homeostasis integral component of postsynaptic membrane uc012gzy.1 uc012gzy.2 uc012gzy.3 uc012gzy.4 
ENSMUST00000023965.8 Cfhr1 ENSMUST00000023965.8 complement factor H-related 1 (from RefSeq NM_015780.2) Cfhl1 Cfhr1 ENSMUST00000023965.1 ENSMUST00000023965.2 ENSMUST00000023965.3 ENSMUST00000023965.4 ENSMUST00000023965.5 ENSMUST00000023965.6 ENSMUST00000023965.7 NM_015780 Q61406 Q61406_MOUSE uc007cwl.1 uc007cwl.2 uc007cwl.3 Lacks conserved residue(s) required for the propagation of feature annotation. negative regulation of protein binding macromolecular complex protein homodimerization activity positive regulation of cytolysis protein heterodimerization activity uc007cwl.1 uc007cwl.2 uc007cwl.3 
ENSMUST00000023978.3 Lcn9 ENSMUST00000023978.3 lipocalin 9 (from RefSeq NM_029959.2) ENSMUST00000023978.1 ENSMUST00000023978.2 LCN9_MOUSE NM_029959 Q80ZC4 Q9D267 uc008itm.1 uc008itm.2 Secreted. Expressed in epididymis. Not detected in all other tissues tested. First detected after 3 weeks postnatal development. Belongs to the calycin superfamily. Lipocalin family. cellular_component extracellular region biological_process small molecule binding uc008itm.1 uc008itm.2 
ENSMUST00000023994.10 Serping1 ENSMUST00000023994.10 serine (or cysteine) peptidase inhibitor, clade G, member 1, transcript variant 1 (from RefSeq NM_009776.4) A2ATR7 C1nh ENSMUST00000023994.1 ENSMUST00000023994.2 ENSMUST00000023994.3 ENSMUST00000023994.4 ENSMUST00000023994.5 ENSMUST00000023994.6 ENSMUST00000023994.7 ENSMUST00000023994.8 ENSMUST00000023994.9 IC1_MOUSE NM_009776 O88330 P97290 Q99M43 Q9QX09 uc008kje.1 uc008kje.2 uc008kje.3 uc008kje.4 Activation of the C1 complex is under control of the C1- inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein. Interacts with MASP1. Secreted. Belongs to the serpin family. negative regulation of complement activation, lectin pathway immune system process serine-type endopeptidase inhibitor activity extracellular region extracellular space complement activation, classical pathway blood coagulation hemostasis negative regulation of peptidase activity negative regulation of endopeptidase activity regulation of blood coagulation peptidase inhibitor activity fibrinolysis innate immune response negative regulation of complement activation uc008kje.1 uc008kje.2 uc008kje.3 uc008kje.4 
ENSMUST00000024005.8 Scg5 ENSMUST00000024005.8 secretogranin V, transcript variant 11 (from RefSeq NR_185217.1) ENSMUST00000024005.1 ENSMUST00000024005.2 ENSMUST00000024005.3 ENSMUST00000024005.4 ENSMUST00000024005.5 ENSMUST00000024005.6 ENSMUST00000024005.7 NR_185217 Q3TT51 Q3TT51_MOUSE Scg5 Sgne1 uc008lpq.1 uc008lpq.2 uc008lpq.3 Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages. Secreted Belongs to the 7B2 family. neuropeptide signaling pathway secretory granule unfolded protein binding uc008lpq.1 uc008lpq.2 uc008lpq.3 
ENSMUST00000024011.10 Kcnk5 ENSMUST00000024011.10 potassium channel, subfamily K, member 5 (from RefSeq NM_021542.4) ENSMUST00000024011.1 ENSMUST00000024011.2 ENSMUST00000024011.3 ENSMUST00000024011.4 ENSMUST00000024011.5 ENSMUST00000024011.6 ENSMUST00000024011.7 ENSMUST00000024011.8 ENSMUST00000024011.9 Kcnk5 NM_021542 Q9JK62 Q9JK62_MOUSE uc007siz.1 uc007siz.2 uc007siz.3 Membrane ; Multi- pass membrane protein Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. voltage-gated potassium channel activity potassium channel activity integral component of plasma membrane ion transport membrane integral component of membrane potassium ion leak channel activity stabilization of membrane potential potassium ion transmembrane transport potassium ion import across plasma membrane uc007siz.1 uc007siz.2 uc007siz.3 
ENSMUST00000024015.3 Guca2a ENSMUST00000024015.3 guanylate cyclase activator 2a (guanylin) (from RefSeq NM_008190.1) ENSMUST00000024015.1 ENSMUST00000024015.2 GUC2A_MOUSE Guca2 NM_008190 P33680 uc008umv.1 uc008umv.2 uc008umv.3 Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. Secreted. Localized in both crypts and villi in the small intestine and to superficial epithelial cells in the colon. Belongs to the guanylin family. extracellular region guanylate cyclase activator activity positive regulation of guanylate cyclase activity uc008umv.1 uc008umv.2 uc008umv.3 
ENSMUST00000024026.4 Cypt1 ENSMUST00000024026.4 cysteine-rich perinuclear theca 1, transcript variant 1 (from RefSeq NM_025738.3) B1AX51 CYPT1_MOUSE Ckt1r3 Cypt1 Cypt5 ENSMUST00000024026.1 ENSMUST00000024026.2 ENSMUST00000024026.3 NM_025738 Q3MSD0 Q3MSD1 Q6P8T4 Q8CH20 Q9D4K2 Q9D9I2 uc009sry.1 uc009sry.2 uc009sry.3 uc009sry.4 uc009sry.5 Cytoplasm, cytoskeleton, perinuclear theca Note=Found in the postacrosomal region of the perinuclear theca. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CH20-1; Sequence=Displayed; Name=2; IsoId=Q8CH20-2; Sequence=VSP_059219; Specifically expressed in spermatozoa (at protein level). Detected from the elongated spermatid stage onwards; not found in immature germ cells or somatic cells (at protein level). Detected from 29 days postpartum onwards, with increasing expression through to the adult stage. acrosomal vesicle molecular_function cytoplasm cytoskeleton biological_process perinuclear theca uc009sry.1 uc009sry.2 uc009sry.3 uc009sry.4 uc009sry.5 
ENSMUST00000024031.13 Acy1 ENSMUST00000024031.13 aminoacylase 1, transcript variant 1 (from RefSeq NM_025371.3) A0A0R4J050 A0A0R4J050_MOUSE Acy1 ENSMUST00000024031.1 ENSMUST00000024031.10 ENSMUST00000024031.11 ENSMUST00000024031.12 ENSMUST00000024031.2 ENSMUST00000024031.3 ENSMUST00000024031.4 ENSMUST00000024031.5 ENSMUST00000024031.6 ENSMUST00000024031.7 ENSMUST00000024031.8 ENSMUST00000024031.9 NM_025371 uc009rjp.1 uc009rjp.2 uc009rjp.3 uc009rjp.4 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. Cytoplasm Belongs to the peptidase M20A family. aminoacylase activity cytoplasm proteolysis cellular amino acid metabolic process metallopeptidase activity hydrolase activity uc009rjp.1 uc009rjp.2 uc009rjp.3 uc009rjp.4 
ENSMUST00000024032.4 9530002B09Rik ENSMUST00000024032.4 RIKEN cDNA 9530002B09 gene (from RefSeq NM_023865.3) 9530002B09Rik Aump ENSMUST00000024032.1 ENSMUST00000024032.2 ENSMUST00000024032.3 NM_023865 Q9EPV7 Q9EPV7_MOUSE uc008uof.1 uc008uof.2 uc008uof.3 uc008uof.1 uc008uof.2 uc008uof.3 
ENSMUST00000024035.9 Gabrr2 ENSMUST00000024035.9 gamma-aminobutyric acid type A receptor subunit rho 2, transcript variant 1 (from RefSeq NM_008076.4) ENSMUST00000024035.1 ENSMUST00000024035.2 ENSMUST00000024035.3 ENSMUST00000024035.4 ENSMUST00000024035.5 ENSMUST00000024035.6 ENSMUST00000024035.7 ENSMUST00000024035.8 GBRR2_MOUSE NM_008076 P56476 Q6PEP0 uc008sfq.1 uc008sfq.2 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 (By similarity). Postsynaptic cell membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=P56476-1; Sequence=Displayed; Name=2; IsoId=P56476-2; Sequence=VSP_044374; [Isoform 2]: Isoform 2 could be translated from an upstream initiator ATG located in frame within the first coding exon. The probability of a signal peptide within this isoform is very low. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub- subfamily. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction gamma-aminobutyric acid signaling pathway chemical synaptic transmission visual perception membrane integral component of membrane protein domain specific binding cell junction axon ion transmembrane transport chloride channel complex regulation of membrane potential neuron projection synapse postsynaptic membrane neurological system process regulation of postsynaptic membrane potential GABA-ergic synapse chloride transmembrane transport transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential eye photoreceptor cell development uc008sfq.1 uc008sfq.2 
ENSMUST00000024042.5 Creld2 ENSMUST00000024042.5 cysteine-rich with EGF-like domains 2 (from RefSeq NM_029720.2) CREL2_MOUSE ENSMUST00000024042.1 ENSMUST00000024042.2 ENSMUST00000024042.3 ENSMUST00000024042.4 NM_029720 Q9CYA0 uc007xep.1 uc007xep.2 uc007xep.3 Protein disulfide isomerase (Probable). Might play a role in the unfolded protein response (Probable). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity). Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; Evidence=; Interacts with CHRNA4 (By similarity). Component of a complex containing at least CRELD2, MANF, MATN3 and PDIA4 (PubMed:23956175). Endoplasmic reticulum Expressed in chondrocytes (at protein level). Expressed from birth. Secreted under some pathological conditions such as skeletal diseases. Belongs to the CRELD family. protein disulfide isomerase activity extracellular matrix structural constituent calcium ion binding extracellular region extracellular space endoplasmic reticulum Golgi apparatus biological_process uc007xep.1 uc007xep.2 uc007xep.3 
ENSMUST00000024044.7 Cd4 ENSMUST00000024044.7 CD4 antigen (from RefSeq NM_013488.3) Cd4 ENSMUST00000024044.1 ENSMUST00000024044.2 ENSMUST00000024044.3 ENSMUST00000024044.4 ENSMUST00000024044.5 ENSMUST00000024044.6 NM_013488 Q3TSV7 Q3TSV7_MOUSE uc009dsi.1 uc009dsi.2 uc009dsi.3 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein positive regulation of protein phosphorylation plasma membrane integral component of plasma membrane induction by virus of host cell-cell fusion immune response cell adhesion zinc ion binding external side of plasma membrane coreceptor activity membrane integral component of membrane enzyme binding protein kinase binding T cell differentiation macrophage differentiation maintenance of protein location in cell positive regulation of kinase activity interleukin-15-mediated signaling pathway interleukin-16 binding interleukin-16 receptor activity MHC class II protein binding identical protein binding protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade T cell selection membrane raft positive regulation of monocyte differentiation positive regulation of protein kinase activity positive regulation of transcription, DNA-templated positive regulation of viral entry into host cell regulation of T cell activation regulation of calcium ion transport positive regulation of ERK1 and ERK2 cascade cellular response to granulocyte macrophage colony-stimulating factor stimulus protein tyrosine kinase binding uc009dsi.1 uc009dsi.2 uc009dsi.3 
ENSMUST00000024047.12 Twf2 ENSMUST00000024047.12 twinfilin actin binding protein 2 (from RefSeq NM_011876.3) ENSMUST00000024047.1 ENSMUST00000024047.10 ENSMUST00000024047.11 ENSMUST00000024047.2 ENSMUST00000024047.3 ENSMUST00000024047.4 ENSMUST00000024047.5 ENSMUST00000024047.6 ENSMUST00000024047.7 ENSMUST00000024047.8 ENSMUST00000024047.9 NM_011876 Ptk9l Q3TD06 Q3TZG2 Q8BN77 Q9DCK8 Q9Z0P5 TWF2_MOUSE uc009rjf.1 uc009rjf.2 uc009rjf.3 Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. Interacts with G-actin; ADP-actin form and capping protein (CP). Isoform 2 interacts (via its N-terminal ADF-H domain) with G- actin (ADP-bound form) with significantly higher affinity than isoform 1. May also be able to interact with TWF1 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated. Interacts with MYO7A. Cytoplasm, cytoskeleton Cytoplasm, perinuclear region Cell projection, stereocilium Note=Perinuclear and G-actin-rich cortical actin structure sublocalization. Isoform 2 found also along myofibrils in cardiomyocytes (PubMed:18837697). Localized in cochlea hair cells to the tips of the middle and short rows of stereocilia (PubMed:19955359). Event=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=Twf2a; IsoId=Q9Z0P5-1; Sequence=Displayed; Name=2; Synonyms=Twf2b; IsoId=Q9Z0P5-2; Sequence=VSP_018053; Isoform 1 is ubiquitously expressed (at protein level). Isoform 2 expression is restricted to heart and skeletal muscle where it is the predominant form. Expression was relatively weak during all of the embryonic stages. At 14.5 dpc, a slight increase in the expression could be observed in heart, CNS, and PNS. At 18.5 dpc, it is strongly expressed in the inner ear, hair cells and in the head muscles. No expression is detected in the nasal epithelium or in the skin keratinocytes. Phosphorylated on both serine/threonine and tyrosine. Mice lacking isoform 1 develop normally to adulthood, are fertile, and do not exhibit obvious morphological or behavioral abnormalities. Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. Name=Protein Spotlight; Note=Molecular embrace - Issue 73 of August 2006; URL="https://web.expasy.org/spotlight/back_issues/073"; actin binding actin monomer binding protein kinase C binding ATP binding phosphatidylinositol-4,5-bisphosphate binding cell cytoplasm cytoskeleton actin filament multicellular organism development regulation of lamellipodium assembly positive regulation of lamellipodium assembly positive regulation of neuron projection development myofibril lamellipodium cell projection organization actin filament depolymerization filopodium growth cone negative regulation of actin filament polymerization stereocilium regulation of microvillus length regulation of actin cytoskeleton organization intracellular signal transduction sequestering of actin monomers cell projection positive regulation of axon extension perinuclear region of cytoplasm actin filament binding barbed-end actin filament capping cellular response to retinoic acid cellular response to growth factor stimulus uc009rjf.1 uc009rjf.2 uc009rjf.3 
ENSMUST00000024049.8 Bmp15 ENSMUST00000024049.8 bone morphogenetic protein 15 (from RefSeq NM_009757.5) BMP15_MOUSE ENSMUST00000024049.1 ENSMUST00000024049.2 ENSMUST00000024049.3 ENSMUST00000024049.4 ENSMUST00000024049.5 ENSMUST00000024049.6 ENSMUST00000024049.7 Gdf9b NM_009757 Q3UT46 Q9Z0L4 uc009skx.1 uc009skx.2 uc009skx.3 uc009skx.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Female mice lacking a functional copy of this gene exhibit impaired fertility. [provided by RefSeq, Aug 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK139847.1, BC055363.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). Homodimer (By similarity). But, in contrast to other members of this family, cannot be disulfide-linked. Secreted. Ovary specific. Belongs to the TGF-beta family. ovarian follicle development cytokine activity transforming growth factor beta receptor binding extracellular region extracellular space cytoplasm growth factor activity positive regulation of pathway-restricted SMAD protein phosphorylation BMP signaling pathway regulation of apoptotic process regulation of MAPK cascade positive regulation of transcription, DNA-templated cell development granulosa cell development SMAD protein signal transduction uc009skx.1 uc009skx.2 uc009skx.3 uc009skx.4 
ENSMUST00000024078.15 Marchf5 ENSMUST00000024078.15 membrane associated ring-CH-type finger 5, transcript variant 1 (from RefSeq NM_027314.3) ENSMUST00000024078.1 ENSMUST00000024078.10 ENSMUST00000024078.11 ENSMUST00000024078.12 ENSMUST00000024078.13 ENSMUST00000024078.14 ENSMUST00000024078.2 ENSMUST00000024078.3 ENSMUST00000024078.4 ENSMUST00000024078.5 ENSMUST00000024078.6 ENSMUST00000024078.7 ENSMUST00000024078.8 ENSMUST00000024078.9 MARH5_MOUSE March5 NM_027314 Q3KNM2 Q3KNM3 Q6P230 Q9CPS3 Q9CTI6 uc008hig.1 uc008hig.2 uc008hig.3 uc008hig.4 uc008hig.5 Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Monomer and homodimer. Interacts with MFN1, MFN2, DNM1L and FIS1. Mitochondrion outer membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein The RING-CH-type zinc finger domain is required for E3 ligase activity. Autoubiquitinated leading to degradation. protein polyubiquitination ubiquitin-protein transferase activity mitochondrion mitochondrial outer membrane endoplasmic reticulum endoplasmic reticulum membrane zinc ion binding membrane integral component of membrane protein ubiquitination transferase activity metal ion binding GTPase binding protein autoubiquitination protein localization to mitochondrion regulation of mitochondrial fission positive regulation of mitochondrial fission negative regulation of cell aging uc008hig.1 uc008hig.2 uc008hig.3 uc008hig.4 uc008hig.5 
ENSMUST00000024099.11 Ache ENSMUST00000024099.11 acetylcholinesterase, transcript variant 2 (from RefSeq NM_009599.4) Ache ENSMUST00000024099.1 ENSMUST00000024099.10 ENSMUST00000024099.2 ENSMUST00000024099.3 ENSMUST00000024099.4 ENSMUST00000024099.5 ENSMUST00000024099.6 ENSMUST00000024099.7 ENSMUST00000024099.8 ENSMUST00000024099.9 NM_009599 Q543Z1 Q543Z1_MOUSE uc009abu.1 uc009abu.2 uc009abu.3 uc009abu.4 Cell membrane ; Peripheral membrane protein Membrane ; Peripheral membrane protein Secreted Synapse Belongs to the type-B carboxylesterase/lipase family. osteoblast development acetylcholinesterase activity cholinesterase activity collagen binding extracellular region Golgi apparatus acetylcholine catabolic process cell adhesion membrane hydrolase activity serine hydrolase activity acetylcholine binding protein homodimerization activity laminin binding synapse perinuclear region of cytoplasm uc009abu.1 uc009abu.2 uc009abu.3 uc009abu.4 
ENSMUST00000024104.9 Gcm1 ENSMUST00000024104.9 glial cells missing homolog 1 (from RefSeq NM_008103.3) ENSMUST00000024104.1 ENSMUST00000024104.2 ENSMUST00000024104.3 ENSMUST00000024104.4 ENSMUST00000024104.5 ENSMUST00000024104.6 ENSMUST00000024104.7 ENSMUST00000024104.8 Gcm1 NM_008103 Q3UQD1 Q3UQD1_MOUSE uc009qto.1 uc009qto.2 uc009qto.3 RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated transcription from RNA polymerase II promoter transcription factor binding histone deacetylase binding positive regulation of transcription from RNA polymerase II promoter regulation of cell differentiation involved in embryonic placenta development uc009qto.1 uc009qto.2 uc009qto.3 
ENSMUST00000024107.7 Wfdc1 ENSMUST00000024107.7 WAP four-disulfide core domain 1 (from RefSeq NM_023395.2) ENSMUST00000024107.1 ENSMUST00000024107.2 ENSMUST00000024107.3 ENSMUST00000024107.4 ENSMUST00000024107.5 ENSMUST00000024107.6 NM_023395 Ps20 Q8R110 Q9ESH5 WFDC1_MOUSE uc009nqe.1 uc009nqe.2 uc009nqe.3 Has growth inhibitory activity. Secreted regulation of cell growth molecular_function serine-type endopeptidase inhibitor activity extracellular region extracellular space negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to estradiol response to drug negative regulation of epithelial cell proliferation negative regulation of inflammatory response negative regulation of wound healing uc009nqe.1 uc009nqe.2 uc009nqe.3 
ENSMUST00000024118.11 Clec4n ENSMUST00000024118.11 C-type lectin domain family 4, member n, transcript variant 1 (from RefSeq NM_020001.2) CLC6A_MOUSE Clec6a Clecsf10 Dectin2 ENSMUST00000024118.1 ENSMUST00000024118.10 ENSMUST00000024118.2 ENSMUST00000024118.3 ENSMUST00000024118.4 ENSMUST00000024118.5 ENSMUST00000024118.6 ENSMUST00000024118.7 ENSMUST00000024118.8 ENSMUST00000024118.9 NM_020001 Q9JKF2 Q9JKF3 Q9JKF4 uc009dqe.1 uc009dqe.2 uc009dqe.3 uc009dqe.4 Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:17050534, PubMed:19703985, PubMed:20493731). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T- cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:17050534, PubMed:19703985, PubMed:20493731, PubMed:32358020). Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (PubMed:19124755). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (PubMed:21059925). Associated with FCER1G (PubMed:17050534). Heterodimer with CLEC4D; this heterodimer forms a pattern recognition receptor (PRR) against fungal infection (By similarity). Cell membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha; IsoId=Q9JKF4-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q9JKF4-2; Sequence=VSP_012846; Name=3; Synonyms=Gamma; IsoId=Q9JKF4-3; Sequence=VSP_012847; Expressed by the XS52 DC (dendritic cell) line (at protein level). Expressed constitutively by the epidermis, and skin resident DC appear to be the major source of this expression. Expressed in the spleen and thymus. Expression was undetectable in non-DC lines, including macrophage lines (J774 and Raw), T-cell lines (7-17, HDK-1, and D10), B-cell hybridoma (5C5), a keratinocyte line (Pam 212), and a fibroblast line (NS01). A short stretch of the intracellular domain (AA 8-14) proximal to the transmembrane domain is required for association with Fc receptor gamma chain. Deficient mice are healthy, fertile, with normal lymphoid cells, but show reduced survival after intravenous Candida albicans infection (PubMed:20493731). In deficient mice fungal burden is higher in kidneys of mutant and in response to yeast antigen inflammatory cytokines and Th17 cells are reduced (PubMed:20493731). Name=Functional Glycomics Gateway - Glycan Binding; Note=Dectin-2; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_361"; adaptive immune response immune system process calcium ion binding protein binding mannose binding plasma membrane membrane integral component of membrane carbohydrate binding positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response metal ion binding positive regulation of cytokine secretion defense response to fungus uc009dqe.1 uc009dqe.2 uc009dqe.3 uc009dqe.4 
ENSMUST00000024119.11 Trip6 ENSMUST00000024119.11 thyroid hormone receptor interactor 6, transcript variant 4 (from RefSeq NR_184539.1) ENSMUST00000024119.1 ENSMUST00000024119.10 ENSMUST00000024119.2 ENSMUST00000024119.3 ENSMUST00000024119.4 ENSMUST00000024119.5 ENSMUST00000024119.6 ENSMUST00000024119.7 ENSMUST00000024119.8 ENSMUST00000024119.9 NR_184539 Q3TX74 Q9Z1Y4 TRIP6_MOUSE Zrp1 uc009acd.1 uc009acd.2 uc009acd.3 Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF- kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (By similarity). Specifically interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone (By similarity). Interacts (via the third LIM domain and C-terminus) with PTPN13 (via the second PDZ domain). Interacts (via the second LIM domain or via the third LIM domain plus C-terminus) with PDLIM4 (via PDZ domain). Found in a complex with PTPN13 and PDLIM4 (PubMed:10826496). Interacts with SVIL isoform 2. Interacts with LPAR2 but not other LPA receptors. Interacts with PRKAA2. Interacts with MAGI1. Interacts with SCRIB (By similarity). In case of infection, interacts with S.typhimurium protein sseI (PubMed:17095609). Q9Z1Y4; P70271: Pdlim4; NbExp=2; IntAct=EBI-643879, EBI-7288319; Cytoplasm, cytoskeleton Cell junction, focal adhesion Nucleus Cytoplasm Note=Shuttles between nucleus and cytoplasm. Colocalizes with actin. Highly expressed in kidney, stomach, lung, heart and testis. Low expression levels in brain, colon, thymus, pancreas and skin. Not expressed in skeletal muscle. Expressed throughout development in all embryonic stages analyzed, 10.5 days post coitum (dpc) to 18.5 dpc. In 16.5 dpc embryos highly expressed in skin, lung, thymus, duodenum and the ependymal cell layer surrounding the ventricles in brain. Highly expressed also in the salivary glands, tongue, vibrissae, choroid plexus, blood vessel walls, esophagus and midgut. Low expression levels in spinal cord, heart and liver. The LIM zinc-binding domains mediate interaction with LPAR2. Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13 (By similarity). Belongs to the zyxin/ajuba family. stress fiber interleukin-1 receptor binding protein binding nucleus cytoplasm cytosol cytoskeleton plasma membrane focal adhesion cell adhesion signal transduction kinase binding cell junction positive regulation of cell migration metal ion binding positive regulation of NIK/NF-kappaB signaling uc009acd.1 uc009acd.2 uc009acd.3 
ENSMUST00000024123.9 Agap3 ENSMUST00000024123.9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3, transcript variant 1 (from RefSeq NM_139153.2) Agap3 ENSMUST00000024123.1 ENSMUST00000024123.2 ENSMUST00000024123.3 ENSMUST00000024123.4 ENSMUST00000024123.5 ENSMUST00000024123.6 ENSMUST00000024123.7 ENSMUST00000024123.8 F8VQE9 F8VQE9_MOUSE NM_139153 uc008wrv.1 uc008wrv.2 Belongs to the centaurin gamma-like family. nucleotide binding GTPase activity GTPase activator activity GTP binding signal transduction membrane positive regulation of GTPase activity metal ion binding uc008wrv.1 uc008wrv.2 
ENSMUST00000024155.9 Kcnk16 ENSMUST00000024155.9 potassium channel, subfamily K, member 16 (from RefSeq NM_029006.2) ENSMUST00000024155.1 ENSMUST00000024155.2 ENSMUST00000024155.3 ENSMUST00000024155.4 ENSMUST00000024155.5 ENSMUST00000024155.6 ENSMUST00000024155.7 ENSMUST00000024155.8 G5E845 G5E845_MOUSE Kcnk16 NM_029006 uc011zgl.1 uc011zgl.2 uc011zgl.3 Membrane ; Multi- pass membrane protein Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. potassium channel activity integral component of plasma membrane ion transport potassium ion transport membrane integral component of membrane potassium ion leak channel activity stabilization of membrane potential potassium ion transmembrane transport uc011zgl.1 uc011zgl.2 uc011zgl.3 
ENSMUST00000024159.8 Dlx2 ENSMUST00000024159.8 distal-less homeobox 2 (from RefSeq NM_010054.3) Dlx2 ENSMUST00000024159.1 ENSMUST00000024159.2 ENSMUST00000024159.3 ENSMUST00000024159.4 ENSMUST00000024159.5 ENSMUST00000024159.6 ENSMUST00000024159.7 NM_010054 Q52KJ2 Q52KJ2_MOUSE uc008kax.1 uc008kax.2 uc008kax.3 Nucleus Belongs to the distal-less homeobox family. DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc008kax.1 uc008kax.2 uc008kax.3 
ENSMUST00000024171.14 Stk31 ENSMUST00000024171.14 serine threonine kinase 31, transcript variant 1 (from RefSeq NM_029916.2) B2RQM2 E9QLI8 ENSMUST00000024171.1 ENSMUST00000024171.10 ENSMUST00000024171.11 ENSMUST00000024171.12 ENSMUST00000024171.13 ENSMUST00000024171.2 ENSMUST00000024171.3 ENSMUST00000024171.4 ENSMUST00000024171.5 ENSMUST00000024171.6 ENSMUST00000024171.7 ENSMUST00000024171.8 ENSMUST00000024171.9 NM_029916 Q99MW1 STK31_MOUSE uc009bws.1 uc009bws.2 uc009bws.3 uc009bws.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Testis specific. Expressed only in male germ cells. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Ser-855 is present instead of the conserved Asp which is expected to be an active site residue. nucleotide binding acrosomal vesicle RNA binding nuclease activity protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm RNA catabolic process protein phosphorylation kinase activity phosphorylation transferase activity nucleic acid phosphodiester bond hydrolysis uc009bws.1 uc009bws.2 uc009bws.3 uc009bws.4 
ENSMUST00000024179.6 Nfatc4 ENSMUST00000024179.6 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4, transcript variant 1 (from RefSeq NM_023699.3) B5B2X2 ENSMUST00000024179.1 ENSMUST00000024179.2 ENSMUST00000024179.3 ENSMUST00000024179.4 ENSMUST00000024179.5 NFAC4_MOUSE NM_023699 Nfat3 Nfatc4 Q3TXW7 Q8K120 Q9EP91 uc007uax.1 uc007uax.2 uc007uax.3 Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:17198697). Along with NFATC3, involved in embryonic heart development (PubMed:12750314, PubMed:17198697). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (PubMed:12750314). Transactivates many genes involved in heart physiology. Along with GATA4, binds to and activates NPPB/BNP promoter (PubMed:9568714). Activates NPPA/ANP/ANF and MYH7/beta-MHC transcription (By similarity). Binds to and transactivates AGTR2 gene promoter (PubMed:17198697). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (PubMed:22586092). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during a developmental critical period when auditory neurons depend on afferent input for survival (PubMed:18354019). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP). Plays a role in adipocyte differentiation. May be involved in myoblast differentiation into myotubes (By similarity). Binds the consensus DNA sequence 5'- GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription. Binds to PPARG gene promoter and regulates its activity (By similarity). Binds to PPARG and REG3G gene promoters (PubMed:17198697). Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other NFAT proteins, such as NFATC3, or members of the activating protein-1 (AP-1) family and MAF can also bind the complex. NFAT proteins can bind DNA as monomers or dimers (Probable). Interacts with CREBBP; this interaction potentiates transcription activation (By similarity). Interacts with MAPK8/JNK1 and MAPK9/JNK2 (By similarity). Interacts with GATA4 (via the second Zn finger) (PubMed:9568714). Interacts (via N-terminus) with IRAK1 (via C-terminus) (By similarity). Interacts with RPS6KA3 (By similarity). Interacts with HOMER1, HOMER2 and HOMER3; this interaction competes with calcineurin/PPP3CA-binding and hence prevents NFATC4 dephosphorylation and activation (By similarity). Interacts with ESR1 and ESR2; this interaction decreases NFATC4 transcriptional activity (By similarity). Interacts with MTOR and MAPK7/ERK5 (By similarity). Interacts with TRIM17; this interaction prevents NFATC3 nuclear localization (PubMed:25215946). Cytoplasm cleus te=When hyperphosphorylated, localizes in the cytosol. When intracellular Ca(2+) levels increase, dephosphorylation by calcineurin/PPP3CA leads to translocation into the nucleus (By similarity). MAPK7/ERK5 and MTOR regulate NFATC4 nuclear export through phosphorylation at Ser-168 and Ser-170 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1 Synonyms=I-IXL ; IsoId=Q8K120-1; Sequence=Displayed; Name=2 ; Synonyms=I-IXi ; IsoId=Q8K120-2; Sequence=VSP_053054, VSP_053055; Widely expressed (PubMed:18675896). In the brain, expressed in neurons (PubMed:18675896, PubMed:25663301). Expressed in the hippocampus (at protein level) (PubMed:25663301). In the hippocampus, expressed in both the CA1-CA3 pyramidal cells and the dentate gyrus granular cells (PubMed:22586092). Expressed in a subset of hippocampal cells representing adult-born neurons (at protein level) (PubMed:22586092). Expressed in the submandibular gland (at protein level) (PubMed:21435446). In the olfactory system, expressed at low levels in the glomerular and granular layers and in the mitral cell layer (PubMed:18675896). In the cerebellum, expressed at moderate levels in granular neurons (PubMed:18675896). Expressed at moderate levels in the choroid plexus and ependymal cells (PubMed:18675896). Expressed in neurons of the cochlear nucleus (at protein level) (PubMed:18354019). Expressed at low levels in the heart (at protein level) (PubMed:12370307). Expressed at high levels in the embryonic brain at 13.5 dpc (PubMed:18675896, PubMed:22586092). Expression decreases thereafter, reaching the lowest levels at postnatal day 14 and remaining unchanged in adulthood (PubMed:18675896). Expressed in the developing heart at 13.5 and 16.5 dpc, during the transition from spongy to compact myocardium (PubMed:17198697). Up-regulated by BDNF. Rel similarity domain (RSD) or Rel homology domain (RHD) allows DNA-binding and cooperative interactions with AP-1 factors. Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin/PPP3CA. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7/ERK5 and MAPK14/p38, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3 (PubMed:18691762). Phosphorylated by GSK3B (By similarity). Phosphorylation by GSK3B markedly increases NFATC4 ubiquitination (By similarity). Phosphorylation by MAPK8/JNK1, MAPK9/JNK2 and RPS6KA3 may stimulate NFATC4 transcriptional activity. Phosphorylation at Ser-168 and Ser-170 is stimulated by UV irradiation (By similarity). Ubiquitinated, leading to degradation by the proteasome. Ubiquitination may be stimulated by GSK3B-dependent phosphorylation. Polyubiquitin linkage mainly occurs through 'Lys-48'. No visible phenotype (PubMed:12370307). However, adult mutant animals show selective impairment in the formation of spatial long-term memory and long-term potentiation. They exhibit a reduced number of hippocampal adult-born neurons compared to wild-type littermates (PubMed:22586092). Simultaneous knockout of NFATC3 and NFATC4 results in embryonic death soon after 10.5 dpc. Embryos appear normal at 9.5 dpc. At 10.5 dpc, they exhibit defects in cardiac development, including dilated thin translucent hearts, pericardial effusion and anemia. Despite a mild generalized developmental delay, the heads, tails, and limb buds are well developed. By 11.5 dpc, mutant embryos are either necrotic or resorbed (PubMed:12750314). negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding branching involved in blood vessel morphogenesis cytokine production DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated multicellular organism development heart development long-term memory transcription factor binding intrinsic apoptotic signaling pathway in response to DNA damage nuclear speck cell differentiation negative regulation of Wnt signaling pathway brain-derived neurotrophic factor receptor signaling pathway negative regulation of protein binding positive regulation of tumor necrosis factor production calcineurin-NFAT signaling cascade cellular response to UV negative regulation of chromatin binding peroxisome proliferator activated receptor binding positive regulation of apoptotic process negative regulation of neuron apoptotic process nuclear transcription factor complex cellular respiration positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity negative regulation of dendrite morphogenesis smooth muscle cell differentiation muscle cell development long-term synaptic potentiation cellular response to lithium ion negative regulation of pri-miRNA transcription from RNA polymerase II promoter cellular response to ionomycin negative regulation of synapse maturation positive regulation of apoptotic signaling pathway uc007uax.1 uc007uax.2 uc007uax.3 
ENSMUST00000024200.7 Cela3a ENSMUST00000024200.7 chymotrypsin-like elastase family, member 3A (from RefSeq NM_001126318.1) A2A9U8 A2A9U8_MOUSE Cela3a ENSMUST00000024200.1 ENSMUST00000024200.2 ENSMUST00000024200.3 ENSMUST00000024200.4 ENSMUST00000024200.5 ENSMUST00000024200.6 NM_001126318 uc012dnj.1 uc012dnj.2 serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc012dnj.1 uc012dnj.2 
ENSMUST00000024206.6 Gnb3 ENSMUST00000024206.6 guanine nucleotide binding protein (G protein), beta 3 (from RefSeq NM_013530.1) ENSMUST00000024206.1 ENSMUST00000024206.2 ENSMUST00000024206.3 ENSMUST00000024206.4 ENSMUST00000024206.5 GBB3_MOUSE NM_013530 Q61011 uc009dsd.1 uc009dsd.2 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2 (By similarity). Belongs to the WD repeat G protein beta family. GTPase activity heterotrimeric G-protein complex cell volume homeostasis signal transduction G-protein coupled receptor signaling pathway regulation of gene expression regulation of glucose metabolic process dendrite spectrin binding regulation of hormone metabolic process neuron projection cell body regulation of fat cell differentiation GTPase binding regulation of cholesterol metabolic process regulation of triglyceride metabolic process regulation of phospholipid metabolic process uc009dsd.1 uc009dsd.2 
ENSMUST00000024233.15 Tulp2 ENSMUST00000024233.15 TUB like protein 2, transcript variant 1 (from RefSeq NM_008807.3) ENSMUST00000024233.1 ENSMUST00000024233.10 ENSMUST00000024233.11 ENSMUST00000024233.12 ENSMUST00000024233.13 ENSMUST00000024233.14 ENSMUST00000024233.2 ENSMUST00000024233.3 ENSMUST00000024233.4 ENSMUST00000024233.5 ENSMUST00000024233.6 ENSMUST00000024233.7 ENSMUST00000024233.8 ENSMUST00000024233.9 NM_008807 P46686 Pdet Q3TTV1 Q5FW93 Q8C5R7 Q8C5R9 Q9R1I8 TULP2_MOUSE uc009gvp.1 uc009gvp.2 uc009gvp.3 uc009gvp.4 Cytoplasm Secreted Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P46686-1; Sequence=Displayed; Name=2; IsoId=P46686-2; Sequence=VSP_022199; Name=3; IsoId=P46686-3; Sequence=VSP_022197, VSP_022199; Name=4; IsoId=P46686-4; Sequence=VSP_022197, VSP_022198, VSP_022199; Name=5; IsoId=P46686-5; Sequence=VSP_022197, VSP_022200; Expressed in retina and testis. Belongs to the TUB family. Was originally thought to be a phosphodiesterase on the basis of spurious sequence similarities. Sequence=AAD38452.1; Type=Erroneous initiation; Evidence=; Sequence=BAC36686.1; Type=Erroneous initiation; Evidence=; Sequence=CAA49481.1; Type=Erroneous initiation; Evidence=; extracellular region cytoplasm cilium phosphoric diester hydrolase activity macromolecular complex binding protein localization to cilium uc009gvp.1 uc009gvp.2 uc009gvp.3 uc009gvp.4 
ENSMUST00000024249.5 Prph ENSMUST00000024249.5 peripherin, transcript variant 4 (from RefSeq NM_001411661.1) ENSMUST00000024249.1 ENSMUST00000024249.2 ENSMUST00000024249.3 ENSMUST00000024249.4 G5E846 G5E846_MOUSE NM_001411661 Prph uc007xoo.1 uc007xoo.2 uc007xoo.3 uc007xoo.4 Belongs to the intermediate filament family. structural molecule activity intermediate filament type III intermediate filament intermediate filament cytoskeleton organization uc007xoo.1 uc007xoo.2 uc007xoo.3 uc007xoo.4 
ENSMUST00000024260.14 Pcbp4 ENSMUST00000024260.14 poly(rC) binding protein 4 (from RefSeq NM_021567.5) A0A0R4J044 A0A0R4J044_MOUSE ENSMUST00000024260.1 ENSMUST00000024260.10 ENSMUST00000024260.11 ENSMUST00000024260.12 ENSMUST00000024260.13 ENSMUST00000024260.2 ENSMUST00000024260.3 ENSMUST00000024260.4 ENSMUST00000024260.5 ENSMUST00000024260.6 ENSMUST00000024260.7 ENSMUST00000024260.8 ENSMUST00000024260.9 NM_021567 Pcbp4 uc009rjt.1 uc009rjt.2 uc009rjt.3 uc009rjt.4 uc009rjt.5 uc009rjt.6 nucleic acid binding RNA binding mRNA 3'-UTR binding cytosol regulation of mRNA stability uc009rjt.1 uc009rjt.2 uc009rjt.3 uc009rjt.4 uc009rjt.5 uc009rjt.6 
ENSMUST00000024270.14 Cdca3 ENSMUST00000024270.14 cell division cycle associated 3 (from RefSeq NM_013538.5) C8 CDCA3_MOUSE ENSMUST00000024270.1 ENSMUST00000024270.10 ENSMUST00000024270.11 ENSMUST00000024270.12 ENSMUST00000024270.13 ENSMUST00000024270.2 ENSMUST00000024270.3 ENSMUST00000024270.4 ENSMUST00000024270.5 ENSMUST00000024270.6 ENSMUST00000024270.7 ENSMUST00000024270.8 ENSMUST00000024270.9 Grcc8 NM_013538 O88837 Q8R2V1 Q99M54 Tome1 uc009dsc.1 uc009dsc.2 uc009dsc.3 uc009dsc.4 F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). Protein modification; protein ubiquitination. Interacts with SKP1. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99M54-1; Sequence=Displayed; Name=2; IsoId=Q99M54-2; Sequence=VSP_025606, VSP_025607; The KEN box is required for the association with the APC/C-Cdh1 complex. Ubiquitinated and degraded by the APC/C-Cdh1 complex. Sequence=AAH27172.1; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm cytosol cell-cell adherens junction cell cycle protein ubiquitination cell division uc009dsc.1 uc009dsc.2 uc009dsc.3 uc009dsc.4 
ENSMUST00000024338.5 C1qtnf12 ENSMUST00000024338.5 C1q and tumor necrosis factor related 12 (from RefSeq NM_026125.3) ADIPL_MOUSE C1qdc2 Ctrp12 ENSMUST00000024338.1 ENSMUST00000024338.2 ENSMUST00000024338.3 ENSMUST00000024338.4 Fam132a NM_026125 Q8R2Z0 Q9CQI8 uc008wfp.1 uc008wfp.2 uc008wfp.3 uc008wfp.4 Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue (PubMed:21849507, PubMed:22275362). [Adipolin fC1QTNF12]: Acts by activating the Akt signaling in hepatocytes and adipocytes. Not able to increase insulin-stimulated glucose uptake in adipocytes (PubMed:22942287). [Adipolin gC1QTNF12]: Acts by activating the MAP kinase. Increases insulin-stimulated glucose uptake in adipocytes (PubMed:22942287). Homomultimer; disulfide-linked (PubMed:22942287). Adipolin fC1QTNF12: homotrimer; disulfide-linked (PubMed:22942287). Adipolin gC1QTNF12: homodimer; disulfide-linked (PubMed:22942287). May interact with ERFE. [Adipolin fC1QTNF12]: Secreted [Adipolin gC1QTNF12]: Secreted Note=In serum is the predominant form. Widely expressed, with high expression in subcutaneous and epididymal white adipose tissues and brown adipose tissue. Expressed in adipocytes (at protein level). During adipogenesis. Upon insulin treatment. Up-regulated in obeses mice. Transcription is activated by KLF3 and KLF15. Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by FURIN (PubMed:22942287). Insulin enhances endogenous C1QTNF12 cleavage (PubMed:22942287). Belongs to the adipolin/erythroferrone family. hormone activity extracellular region extracellular space signal transduction regulation of glucose metabolic process positive regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of gluconeogenesis regulation of glucose import positive regulation of glucose import positive regulation of insulin receptor signaling pathway negative regulation of inflammatory response positive regulation of protein kinase B signaling uc008wfp.1 uc008wfp.2 uc008wfp.3 uc008wfp.4 
ENSMUST00000024470.13 Ogfod2 ENSMUST00000024470.13 2-oxoglutarate and iron-dependent oxygenase domain containing 2, transcript variant 1 (from RefSeq NM_025671.4) ENSMUST00000024470.1 ENSMUST00000024470.10 ENSMUST00000024470.11 ENSMUST00000024470.12 ENSMUST00000024470.2 ENSMUST00000024470.3 ENSMUST00000024470.4 ENSMUST00000024470.5 ENSMUST00000024470.6 ENSMUST00000024470.7 ENSMUST00000024470.8 ENSMUST00000024470.9 NM_025671 OGFD2_MOUSE Q78IV7 Q8BMW3 Q9CQ04 uc008zox.1 uc008zox.2 uc008zox.3 Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Belongs to the OGFOD2 family. Sequence=AAH22762.1; Type=Erroneous initiation; Evidence=; Sequence=BAC25517.1; Type=Frameshift; Evidence=; molecular_function iron ion binding cellular_component oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen L-ascorbic acid binding metal ion binding dioxygenase activity oxidation-reduction process uc008zox.1 uc008zox.2 uc008zox.3 
ENSMUST00000024486.14 Mrps23 ENSMUST00000024486.14 mitochondrial ribosomal protein S23, transcript variant 1 (from RefSeq NM_024174.6) ENSMUST00000024486.1 ENSMUST00000024486.10 ENSMUST00000024486.11 ENSMUST00000024486.12 ENSMUST00000024486.13 ENSMUST00000024486.2 ENSMUST00000024486.3 ENSMUST00000024486.4 ENSMUST00000024486.5 ENSMUST00000024486.6 ENSMUST00000024486.7 ENSMUST00000024486.8 ENSMUST00000024486.9 Mrps23 NM_024174 Q8VE22 Q9CXH1 RT23_MOUSE uc007kvi.1 uc007kvi.2 uc007kvi.3 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mS23 family. structural constituent of ribosome mitochondrion mitochondrial small ribosomal subunit ribosome translation nuclear membrane intermediate filament cytoskeleton uc007kvi.1 uc007kvi.2 uc007kvi.3 
ENSMUST00000024518.11 Rhebl1 ENSMUST00000024518.11 Ras homolog enriched in brain like 1 (from RefSeq NM_026967.5) ENSMUST00000024518.1 ENSMUST00000024518.10 ENSMUST00000024518.2 ENSMUST00000024518.3 ENSMUST00000024518.4 ENSMUST00000024518.5 ENSMUST00000024518.6 ENSMUST00000024518.7 ENSMUST00000024518.8 ENSMUST00000024518.9 NM_026967 Q9D8T3 REBL1_MOUSE uc011zzb.1 uc011zzb.2 uc011zzb.3 Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 (By similarity). Interacts with MTOR. Endomembrane system ; Lipid-anchor ; Cytoplasmic side Cytoplasm Belongs to the small GTPase superfamily. Rheb family. nucleotide binding GTPase activity GTP binding cytoplasm plasma membrane signal transduction small GTPase mediated signal transduction endomembrane system membrane GDP binding TOR signaling metal ion binding positive regulation of NF-kappaB transcription factor activity uc011zzb.1 uc011zzb.2 uc011zzb.3 
ENSMUST00000024543.3 Hes7 ENSMUST00000024543.3 hes family bHLH transcription factor 7, transcript variant 1 (from RefSeq NM_033041.5) A3KPD3 ENSMUST00000024543.1 ENSMUST00000024543.2 HES7_MOUSE NM_033041 Q8BKT2 Q99JA6 uc007jpi.1 uc007jpi.2 uc007jpi.3 Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation. Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Nucleus Dynamic expression in the presomitic mesoderm (PSM). At 8.5 dpc, expressed in two bilateral domains: rostral and caudal stripes. The rostral bands are located posterior to the newly formed somite, while the caudal bands extend to the most caudal tip. During 9.0 dpc-12.0 dpc stages, again specifically expressed in two domains of the PSM. By Notch-signaling. Has a particular type of basic domain which includes a helix- interrupting proline. The C-terminal WRPW motif is a transcriptional repression motif which is necessary for interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy- related proteins. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development somitogenesis DNA binding nucleus regulation of transcription, DNA-templated Notch signaling pathway multicellular organism development transcription factor binding anterior/posterior pattern specification cell differentiation post-anal tail morphogenesis negative regulation of transcription, DNA-templated protein dimerization activity rhythmic process regulation of neurogenesis uc007jpi.1 uc007jpi.2 uc007jpi.3 
ENSMUST00000024572.10 Rsph3b ENSMUST00000024572.10 radial spoke 3B homolog (Chlamydomonas) (from RefSeq NM_001083945.1) ENSMUST00000024572.1 ENSMUST00000024572.2 ENSMUST00000024572.3 ENSMUST00000024572.4 ENSMUST00000024572.5 ENSMUST00000024572.6 ENSMUST00000024572.7 ENSMUST00000024572.8 ENSMUST00000024572.9 NM_001083945 Q9DA80 RSH3B_MOUSE Rshl2 Rshl2b uc008ahy.1 uc008ahy.2 Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (PubMed:34871179). Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity). Component of the axonemal radial spoke 1 (RS1) and 2 (RS2) complexes, at least composed of spoke head proteins RSPH1, RSPH3B, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the RS1 complex-specific anchor protein IQUB (PubMed:34871179). Interacts with IQUB (By similarity). Interacts with phosphorylated MAPK1 (By similarity). Interacts with MEK1 (By similarity). Interacts with PKA regulatory subunits PRKAR1A and PRKAR1B (By similarity). Interacts with RSPH1 (PubMed:34871179). Interacts with RSPH4A (PubMed:34871179). Interacts with RSPH6A (PubMed:34871179). Interacts with RSPH9 (PubMed:34871179). Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme Expressed in ependymal cells (at protein level). Belongs to the flagellar radial spoke RSP3 family. molecular_function cytoplasm cytoskeleton cilium biological_process cell projection uc008ahy.1 uc008ahy.2 
ENSMUST00000024575.8 Rps6ka2 ENSMUST00000024575.8 ribosomal protein S6 kinase, polypeptide 2 (from RefSeq NM_011299.5) ENSMUST00000024575.1 ENSMUST00000024575.2 ENSMUST00000024575.3 ENSMUST00000024575.4 ENSMUST00000024575.5 ENSMUST00000024575.6 ENSMUST00000024575.7 KS6A2_MOUSE Mapkapk1c NM_011299 Q9D2C0 Q9WUT3 Rsk3 uc008aih.1 uc008aih.2 uc008aih.3 uc008aih.4 Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-570 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-377, allowing binding of PDPK1, which in turn phosphorylates Ser- 218 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD. Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). Interacts with FBXO5; cooperate to induce the metaphase arrest of early blastomeres; increases and stabilizes interaction of FBXO5 with CDC20 (PubMed:15526037). Nucleus Cytoplasm Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity). N-terminal myristoylation results in an activated kinase in the absence of added growth factors. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. nucleotide binding magnesium ion binding oocyte maturation brain renin-angiotensin system protein kinase activity protein serine/threonine kinase activity ribosomal protein S6 kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm spindle protein phosphorylation heart development negative regulation of cell proliferation positive regulation of gene expression cardiac muscle cell apoptotic process kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction positive regulation of apoptotic process negative regulation of cell cycle negative regulation of meiotic nuclear division heart contraction regulation of protein processing cellular response to carbohydrate stimulus meiotic spindle uc008aih.1 uc008aih.2 uc008aih.3 uc008aih.4 
ENSMUST00000024594.9 Agpat4 ENSMUST00000024594.9 1-acylglycerol-3-phosphate O-acyltransferase 4 (from RefSeq NM_026644.2) ENSMUST00000024594.1 ENSMUST00000024594.2 ENSMUST00000024594.3 ENSMUST00000024594.4 ENSMUST00000024594.5 ENSMUST00000024594.6 ENSMUST00000024594.7 ENSMUST00000024594.8 NM_026644 PLCD_MOUSE Q3TKN0 Q8K4X7 Q9DB84 uc008akm.1 uc008akm.2 uc008akm.3 Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:15367102). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (PubMed:24333445). Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19710; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl- sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z- docosahexaenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:55300, ChEBI:CHEBI:57287, ChEBI:CHEBI:57518, ChEBI:CHEBI:74298, ChEBI:CHEBI:82928; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55301; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3- phosphate = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphate + CoA; Xref=Rhea:RHEA:55304, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74565, ChEBI:CHEBI:77098; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55305; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl- sn-glycero-3-phosphate = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z- docosahexaenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:55308, ChEBI:CHEBI:57287, ChEBI:CHEBI:74298, ChEBI:CHEBI:74565, ChEBI:CHEBI:77130; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55309; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z- octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2- (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:55312, ChEBI:CHEBI:57287, ChEBI:CHEBI:74298, ChEBI:CHEBI:74544, ChEBI:CHEBI:138723; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55313; Evidence=; Kinetic parameters: KM=79.3 uM for LPA C16:0 ; KM=42.9 uM for LPA C18:0 ; KM=6.3 uM for docosahexaenoyl-CoA ; Vmax=276.6 nmol/min/mg enzyme for LPA C16:0 ; Vmax=23.2 nmol/min/mg enzyme for LPA C18:0 ; Vmax=109.3 nmol/min/mg enzyme for docosahexaenoyl-CoA ; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 2/3. Endoplasmic reticulum membrane ; Multi-pass membrane protein Expressed at a high levels in the brain, at intermediate or low levels in skeletal muscles, gut, kidney, spleen and lung (PubMed:15367102, PubMed:24333445). Barely detectable in heart and liver (PubMed:15367102). The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. 1-acylglycerol-3-phosphate O-acyltransferase activity mitochondrial outer membrane endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phospholipid metabolic process phospholipid biosynthetic process membrane integral component of membrane CDP-diacylglycerol biosynthetic process transferase activity transferase activity, transferring acyl groups lysophosphatidic acid acyltransferase activity uc008akm.1 uc008akm.2 uc008akm.3 
ENSMUST00000024595.4 Slc22a3 ENSMUST00000024595.4 solute carrier family 22 (organic cation transporter), member 3 (from RefSeq NM_011395.2) ENSMUST00000024595.1 ENSMUST00000024595.2 ENSMUST00000024595.3 NM_011395 Oct3 Q9R209 Q9WTW5 S22A3_MOUSE Slc22a3 uc008aku.1 uc008aku.2 uc008aku.3 uc008aku.4 Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10966924, PubMed:18513366). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:10966924). Functions as a Na(+)- and Cl(-)- independent, bidirectional uniporter (By similarity). Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, homovanillic acid, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain (PubMed:18513366, PubMed:19416912). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency (By similarity). May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (PubMed:10966924). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (By similarity). Mediates the transport of polyamine spermidine and putrescine (By similarity). Mediates the bidirectional transport of polyamine agmatine (By similarity). Also transports guanidine (PubMed:10966924). May also mediate intracellular transport of organic cations, thereby playing a role in amine metabolism and intracellular signaling (PubMed:27659446). Reaction=(R)-noradrenaline(out) = (R)-noradrenaline(in); Xref=Rhea:RHEA:73871, ChEBI:CHEBI:72587; Evidence=; Reaction=(R)-adrenaline(out) = (R)-adrenaline(in); Xref=Rhea:RHEA:73875, ChEBI:CHEBI:71406; Evidence=; Reaction=serotonin(out) = serotonin(in); Xref=Rhea:RHEA:73867, ChEBI:CHEBI:350546; Evidence=; Reaction=dopamine(out) = dopamine(in); Xref=Rhea:RHEA:73863, ChEBI:CHEBI:59905; Evidence=; Reaction=histamine(out) = histamine(in); Xref=Rhea:RHEA:73879, ChEBI:CHEBI:58432; Evidence=; Reaction=tyramine(in) = tyramine(out); Xref=Rhea:RHEA:74783, ChEBI:CHEBI:327995; Evidence=; Reaction=guanidine(out) = guanidine(in); Xref=Rhea:RHEA:73883, ChEBI:CHEBI:30087; Evidence=; Reaction=agmatine(out) = agmatine(in); Xref=Rhea:RHEA:72131, ChEBI:CHEBI:58145; Evidence=; Reaction=spermidine(in) = spermidine(out); Xref=Rhea:RHEA:35039, ChEBI:CHEBI:57834; Evidence=; Reaction=L-histidyl-L-proline diketopiperazine(in) = L-histidyl-L- proline diketopiperazine(out); Xref=Rhea:RHEA:74787, ChEBI:CHEBI:90039; Evidence=; Reaction=(R)-salsolinol(in) = (R)-salsolinol(out); Xref=Rhea:RHEA:74791, ChEBI:CHEBI:194082; Evidence=; pH dependence: Optimum pH is 8.5 for TEA uptake. ; Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Mitochondrion membrane Endomembrane system Nucleus membrane Nucleus outer membrane Note=Located to neuronal and glial endomembranes, including mitochondrial and nuclear membranes. Highly expressed in placenta (PubMed:10966924, PubMed:9933568). Highly expressed in kidney cortex (PubMed:10966924). In kidney, expressed specifically in the proximal and distal convoluted tubules and within Bowman capsule (PubMed:10966924). Expressed in brain, particularly in dopaminergic neurons of the substantia nigra compacta, non-aminergic neurons of the ventral tegmental area, substantia nigra reticulata, locus coeruleus, hippocampus and cortex (PubMed:18513366). In brain, also detected in astrocytes in the substantia nigra reticulata, several hypothalamic nuclei and nigrostriatal region (PubMed:18513366, PubMed:19416912). Expressed in neurons and glial cells of amygdala (PubMed:27659446). Levels are high during gestation, but decrease greatly towards the end of gestation. Contains one proline-rich sequence (Pro-Glu-Ser-Pro-Arg) that is required for transport activity. Knockout mice show altered monoamine neurotransmission in the brain, with decreased intracellular content and increased turnover of aminergic transmitters. Knockout mice show subtle alterations in behaviors such as increased sensitivity to psychostimulants and increased levels of anxiety and stress (PubMed:18513366). Also exhibit impaired removal of the excess extracellular dopamine induced by methamphetamine and increased striatal dopaminergic terminal damage caused by this psychostimulant (PubMed:19416912). Mediates the uptake of clinically used drugs including neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) and platinum-based drug oxaliplatin (PubMed:10966924, PubMed:18513366, PubMed:19416912). Plays a role in the anticancer activity of oxaliplatin and may contribute to antitumor specificity (By similarity). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. dopamine:sodium symporter activity integral component of plasma membrane ion transport organic cation transmembrane transporter activity quaternary ammonium group transmembrane transporter activity organic cation transport quaternary ammonium group transport monoamine transport dopamine transport membrane integral component of membrane toxin transporter activity transmembrane transporter activity regulation of appetite histamine transport histamine uptake transmembrane transport dopamine uptake toxin transport uc008aku.1 uc008aku.2 uc008aku.3 uc008aku.4 
ENSMUST00000024596.10 Slc22a1 ENSMUST00000024596.10 solute carrier family 22 (organic cation transporter), member 1 (from RefSeq NM_009202.5) ENSMUST00000024596.1 ENSMUST00000024596.2 ENSMUST00000024596.3 ENSMUST00000024596.4 ENSMUST00000024596.5 ENSMUST00000024596.6 ENSMUST00000024596.7 ENSMUST00000024596.8 ENSMUST00000024596.9 Lx1 NM_009202 O08966 Oct1 Q9R1Q4 S22A1_MOUSE Slc22a1 uc008akx.1 uc008akx.2 uc008akx.3 uc008akx.4 Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10216142, PubMed:12176030, PubMed:11463829, PubMed:23458604, PubMed:24961373). Functions as a pH- and Na(+)-independent, bidirectional transporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential (i.e. membrane potential and concentration gradient) and substrate selectivity (By similarity). Hydrophobicity is a major requirement for recognition in polyvalent substrates and inhibitors (PubMed:23458604). Primarily expressed in the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds from the blood by hepatic and renal clearance (By similarity). Most likely functions as an uptake carrier in enterocytes contributing to the intestinal elimination of organic cations from the systemic circulation (PubMed:11463829, PubMed:24961373). Transports endogenous monoamines such as N-1- methylnicotinamide (NMN), guanidine, neurotransmitters dopamine, serotonin, noradrenaline, adrenaline and histamine, and quaternary ammonium compound such as choline (PubMed:24961373, PubMed:35469921). Also transports natural polyamines such as spermidine, agmatine and putrescine at low affinity, but relatively high turnover (PubMed:23458604). Involved in the hepatic and intestinal uptake of the vitamin B1/thiamine, hence regulating hepatic lipid and energy metabolism (PubMed:24961373). Contributes to the influx and efflux of fatty acid carriers carnitines and acylcarnitines across the basolateral membrane of hepatocytes, from the liver to the systemic circulation and inversely and may be involved in regulating the systemic availability of hepatic acylcarnitines (PubMed:28942964, PubMed:34040533). Also capable of transporting non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (By similarity). May contribute to the transport of cationic compounds in testes across the blood-testis-barrier (By similarity). Also mediates the uptake of xenobiotics tributylmethylammonium (TBuMA), quinidine, N-methyl-quinine (NMQ), N- methyl-quinidine (NMQD) N-(4,4-azo-n-pentyl)-quinuclidine (APQ), azidoprocainamide methoiodide (AMP), N-(4,4-azo-n-pentyl)-21- deoxyajmalinium (APDA) and 4-(4-(dimethylamino)styryl)-N- methylpyridinium (ASP) (PubMed:11463829). Reaction=1-methylnicotinamide(out) = 1-methylnicotinamide(in); Xref=Rhea:RHEA:73859, ChEBI:CHEBI:16797; Evidence=; Reaction=dopamine(out) = dopamine(in); Xref=Rhea:RHEA:73863, ChEBI:CHEBI:59905; Evidence=; Reaction=serotonin(out) = serotonin(in); Xref=Rhea:RHEA:73867, ChEBI:CHEBI:350546; Evidence= Reaction=(R)-adrenaline(out) = (R)-adrenaline(in); Xref=Rhea:RHEA:73875, ChEBI:CHEBI:71406; Evidence=; Reaction=(R)-noradrenaline(out) = (R)-noradrenaline(in); Xref=Rhea:RHEA:73871, ChEBI:CHEBI:72587; Evidence=; Reaction=histamine(out) = histamine(in); Xref=Rhea:RHEA:73879, ChEBI:CHEBI:58432; Evidence=; Reaction=guanidine(out) = guanidine(in); Xref=Rhea:RHEA:73883, ChEBI:CHEBI:30087; Evidence=; Reaction=choline(out) = choline(in); Xref=Rhea:RHEA:32751, ChEBI:CHEBI:15354; Evidence=; Reaction=acetylcholine(in) = acetylcholine(out); Xref=Rhea:RHEA:74663, ChEBI:CHEBI:15355; Evidence=; Reaction=thiamine(in) = thiamine(out); Xref=Rhea:RHEA:34919, ChEBI:CHEBI:18385; Evidence= Reaction=spermidine(in) = spermidine(out); Xref=Rhea:RHEA:35039, ChEBI:CHEBI:57834; Evidence=; Reaction=agmatine(out) = agmatine(in); Xref=Rhea:RHEA:72131, ChEBI:CHEBI:58145; Evidence=; Reaction=putrescine(out) = putrescine(in); Xref=Rhea:RHEA:72135, ChEBI:CHEBI:326268; Evidence=; Reaction=(R)-carnitine(in) = (R)-carnitine(out); Xref=Rhea:RHEA:34959, ChEBI:CHEBI:16347; Evidence= Reaction=O-isobutanoyl-(R)-carnitine(in) = O-isobutanoyl-(R)- carnitine(out); Xref=Rhea:RHEA:74315, ChEBI:CHEBI:84838; Evidence= Reaction=O-acetyl-(R)-carnitine(in) = O-acetyl-(R)-carnitine(out); Xref=Rhea:RHEA:74319, ChEBI:CHEBI:57589; Evidence=; Reaction=O-3-hydroxybutanoyl-(R)-carnitine(in) = O-3-hydroxybutanoyl- (R)-carnitine(out); Xref=Rhea:RHEA:74323, ChEBI:CHEBI:84842; Evidence=; Reaction=O-propanoyl-(R)-carnitine(in) = O-propanoyl-(R)- carnitine(out); Xref=Rhea:RHEA:74327, ChEBI:CHEBI:53210; Evidence=; Reaction=O-butanoyl-(R)-carnitine(in) = O-butanoyl-(R)-carnitine(out); Xref=Rhea:RHEA:74331, ChEBI:CHEBI:21949; Evidence=; Reaction=O-2-methylbutanoyl-(R)-carnitine(in) = O-2-methylbutanoyl-(R)- carnitine(out); Xref=Rhea:RHEA:74335, ChEBI:CHEBI:84840; Evidence=; Reaction=O-3-methylbutanoyl-(R)-carnitine(in) = O-3-methylbutanoyl-(R)- carnitine(out); Xref=Rhea:RHEA:74339, ChEBI:CHEBI:70819; Evidence=; Reaction=O-hexanoyl-(R)-carnitine(in) = O-hexanoyl-(R)-carnitine(out); Xref=Rhea:RHEA:74343, ChEBI:CHEBI:84834; Evidence=; Reaction=L-histidyl-L-proline diketopiperazine(in) = L-histidyl-L- proline diketopiperazine(out); Xref=Rhea:RHEA:74787, ChEBI:CHEBI:90039; Evidence=; Reaction=(R)-salsolinol(in) = (R)-salsolinol(out); Xref=Rhea:RHEA:74791, ChEBI:CHEBI:194082; Evidence=; Reaction=prostaglandin F2alpha(out) = prostaglandin F2alpha(in); Xref=Rhea:RHEA:50988, ChEBI:CHEBI:57404; Evidence=; Reaction=prostaglandin E2(out) = prostaglandin E2(in); Xref=Rhea:RHEA:50984, ChEBI:CHEBI:606564; Evidence=; Phosphorylation of the transporter leads to changes in its substrate affinity, resulting in a regulation of the transport activity. In contrast with rat ortholog, ASP uptake is inhibited by protein kinase A (PKA) and C (PKC) activation. ASP uptake is also endogenously activated by calmodulin, the calmodulin-dependent kinase II and LCK tyrosine kinase (By similarity). Inhibited by cGMP, most likely through a cGMP-binding protein that interacts with OCT1 (By similarity). Kinetic parameters: KM=242 uM for adrenaline ; KM=1286 uM for choline ; KM=285 uM for dopamine ; KM=497 uM for histamine ; KM=1470 uM for O-isobutanoyl-(R)-carnitine ; KM=1377 uM for O-isobutanoyl-(R)-carnitine ; KM=409 uM for noradrenaline ; KM=257 uM for serotonin ; KM=143 uM for thiamine ; KM=490 uM for thiamine ; Vmax=7.547 nmol/min/mg enzyme with adrenaline as substrate ; Vmax=16.564 nmol/min/mg enzyme with choline as substrate ; Vmax=1.714 nmol/min/mg enzyme with dopamine as substrate ; Vmax=5.961 nmol/min/mg enzyme with histamine as substrate ; Vmax=8.5 nmol/min/mg enzyme with O-isobutanoyl-(R)-carnitine as substrate ; Vmax=8.366 nmol/min/mg enzyme with O-isobutanoyl-(R)-carnitine as substrate ; Vmax=6.068 nmol/min/mg enzyme with noradrenaline as substrate ; Vmax=16.162 nmol/min/mg enzyme with serotonin as substrate ; Vmax=3.715 nmol/min/mg enzyme with thiamine as substrate ; Vmax=5.8 nmol/min/mg enzyme with thiamine as substrate ; pH dependence: Optimum pH is 8.5 for TEA transport (PubMed:10216142). Optimum pH is 8.4 for MPP(+) transport (PubMed:12176030). ; Basolateral cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Lateral cell membrane ; Multi-pass membrane protein Basal cell membrane ; Multi-pass membrane protein Note=Localized to the sinusoidal/basolateral membrane of hepatocytes (PubMed:28942964). Mainly localized to the basolateral membrane of renal proximal tubular cells (By similarity). However, also identified at the apical side of proximal tubular cells (By similarity). Mainly expressed at the lateral membrane of enterocytes (By similarity). Also observed at the apical side of enterocytes (PubMed:23680637). Localized to the basal membrane of Sertoli cells (By similarity). Expressed in kidney (PubMed:8854860, PubMed:11463829, PubMed:16381671, PubMed:23680637, PubMed:28942964). Expressed in liver (PubMed:8854860, PubMed:11463829, PubMed:16381671, PubMed:24961373, PubMed:28942964). In liver, mainly expressed in the central vein (PubMed:24961373). Expressed in intestines (PubMed:11463829, PubMed:23680637, PubMed:28942964). Weakly expressed in adrenals and in lacting mammary glands (PubMed:8854860). Weakly expressed 2 days before birth, but gradually increased during the first 3 weeks of age, reaching a plateau around day 22 in both kidney and liver. At 45 days of age, renal and hepatic levels is 4 to 6 times higher than the level immediately after birth. Increased by PPARA and PPARG treatment in both liver and H35 cells. A large substrate binding region with partially overlapping binding domains for structurally different substrates is formed by several transmembrane helix domains (TMH) including TMH 2, 4, 10 and 11, and it is alternatingly exposed to the extracellular or intracellular side during substrate transport (By similarity). Amino acids in TMH 1 confer major functional differences between human and mouse orthologs (PubMed:35469921). Contains one proline-rich sequence (Pro-Glu-Ser-Pro-Arg) that is required for transport activity. Phosphorylated. Knockout mice appeared to be viable, healthy and fertile, and displayed no obvious phenotypic abnormalities (PubMed:11463829). Showed slightly greater body weights after 16 weeks compared to wild-type mice (PubMed:24961373). Reduced hepatic uptake and intestinal excretion of organic cations (PubMed:11463829). Showed reduced thiamine and thiamine vitamers levels in liver and intestine and higher levels of thiamine and vitamers in plasma compared to wild- type mice (PubMed:24961373). Also showed increased ratio of AMP to ATP, activation of the energy sensor AMP-activated kinase (AMPK) and increased fatty acid oxidation in the liver, which contributes to reduced hepatic triglyceride (TG) levels (PubMed:24961373). Circulating triglyceride levels were not changed (PubMed:24961373). Involved in the uptake of clinically used drugs including diabete treatment medicine metformin, neurotoxins 1-methyl-4- phenylpyridinium (MPP(+)) and iobenguane and platinum-based drug cisplatin (PubMed:12176030, PubMed:11463829, PubMed:23458604, PubMed:24961373, PubMed:28942964). Metformin competitively inhibits OCT1-mediated thiamine uptake, leading to a decrease in hepatic steatosis (PubMed:24961373). Plays a role in the anticancer activity of cisplatin and may contribute to antitumor specificity (By similarity). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. Cellular localization of OCT1 in the intestine and the kidney remains to be finally defined. While most authors have deduced a localization at the basolateral side of enterocytes consistent with a physiological role in organic anions uptake from the blood flow and intestinal excretion (PubMed:11463829), other studies demonstrated an apical localization (PubMed:23680637), supporting a function in intestinal absorption of organic anions and drugs (PubMed:11463829, PubMed:23680637). Similarly, contradictory findings have shown a localization to the basolateral side (By similarity) or to the apical side (By similarity) of proximal tubules (By similarity). While carnitine efflux is Na(+)-independent, carnitine uptake is significantly reduced in the absence of Na(+) (PubMed:28942964). Not able to uptake and choline in the liver (PubMed:24961373). Affinity and capacity of the transporter for endogenous substrates vary among orthologs (PubMed:34040533, PubMed:35469921). For endogenous compounds such as dopamine, histamine, serotonin and thiamine, mouse ortholog display higher affinity and capacity compared with human OCT1 (PubMed:35469921). In contrast with human ortholog, not involved in metformin efflux transport (PubMed:34040533). acetylcholine transmembrane transporter activity dopamine:sodium symporter activity norepinephrine:sodium symporter activity plasma membrane integral component of plasma membrane ion transport cation transport neurotransmitter transport drug transmembrane transport monoamine transmembrane transporter activity secondary active organic cation transmembrane transporter activity establishment or maintenance of transmembrane electrochemical gradient organic cation transmembrane transporter activity quaternary ammonium group transmembrane transporter activity organic cation transport quaternary ammonium group transport monoamine transport dopamine transport norepinephrine transport membrane integral component of membrane basolateral plasma membrane transmembrane transporter activity identical protein binding protein homodimerization activity epinephrine transport protein homooligomerization norepinephrine uptake transmembrane transport ammonium transmembrane transport dopamine uptake acetate ester transport uc008akx.1 uc008akx.2 uc008akx.3 uc008akx.4 
ENSMUST00000024599.14 Igf2r ENSMUST00000024599.14 insulin-like growth factor 2 receptor (from RefSeq NM_010515.2) ENSMUST00000024599.1 ENSMUST00000024599.10 ENSMUST00000024599.11 ENSMUST00000024599.12 ENSMUST00000024599.13 ENSMUST00000024599.2 ENSMUST00000024599.3 ENSMUST00000024599.4 ENSMUST00000024599.5 ENSMUST00000024599.6 ENSMUST00000024599.7 ENSMUST00000024599.8 ENSMUST00000024599.9 MPRI_MOUSE NM_010515 Q07113 Q61822 Q6LED1 uc008aky.1 uc008aky.2 uc008aky.3 Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose- 6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3 (By similarity). Interacts with the heterotrimeric retromer cargo- selective complex (CSC), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35; which is involved in retrograde trafficking of the receptor from endosomes to the Golgi apparatus (By similarity). Golgi apparatus membrane ; Single-pass type I membrane protein Endosome membrane ; Single-pass type I membrane protein Note=Mainly localized in the Golgi at steady state and not detectable in lysosome. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface. Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends. Palmitoylated. Undergoes cysteine S-palmitoylation which promotes interaction with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus. Belongs to the MRL1/IGF2R family. liver development G-protein alpha-subunit binding retinoic acid binding protein binding insulin-like growth factor binding mannose binding extracellular space nucleus nuclear envelope lumen lysosome lysosomal membrane endosome early endosome late endosome Golgi apparatus trans-Golgi network plasma membrane lysosomal transport G-protein coupled receptor signaling pathway spermatogenesis post-embryonic development cell surface membrane integral component of membrane enzyme binding clathrin coat endocytic vesicle trans-Golgi network transport vesicle animal organ regeneration insulin-like growth factor II binding response to retinoic acid signaling receptor activity identical protein binding regulation of apoptotic process positive regulation of apoptotic process positive regulation by host of viral process perinuclear region of cytoplasm phosphoprotein binding uc008aky.1 uc008aky.2 uc008aky.3 
ENSMUST00000024620.8 Riok2 ENSMUST00000024620.8 RIO kinase 2 (from RefSeq NM_025934.2) ENSMUST00000024620.1 ENSMUST00000024620.2 ENSMUST00000024620.3 ENSMUST00000024620.4 ENSMUST00000024620.5 ENSMUST00000024620.6 ENSMUST00000024620.7 NM_025934 Q91XF3 Q9CQS5 RIOK2_MOUSE uc008ape.1 uc008ape.2 uc008ape.3 uc008ape.4 Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. May regulate the timing of the metaphase- anaphase transition during mitotic progression, and its phosphorylation, may regulate this function. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Associated with late 40S pre-ribosomal particles. Interacts with PLK1 (via its N-terminus). Cytoplasm Autophosphorylated (in vitro). Phosphorylation affects the timing of the metaphase-anaphase transition. Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm cytosol protein phosphorylation kinase activity phosphorylation transferase activity regulation of mitotic metaphase/anaphase transition maturation of SSU-rRNA preribosome, small subunit precursor ribosome biogenesis ribosomal small subunit biogenesis protein autophosphorylation metal ion binding positive regulation of ribosomal small subunit export from nucleus positive regulation of rRNA processing uc008ape.1 uc008ape.2 uc008ape.3 uc008ape.4 
ENSMUST00000024627.14 Chd1 ENSMUST00000024627.14 chromodomain helicase DNA binding protein 1 (from RefSeq NM_007690.3) CHD1_MOUSE Chd-1 ENSMUST00000024627.1 ENSMUST00000024627.10 ENSMUST00000024627.11 ENSMUST00000024627.12 ENSMUST00000024627.13 ENSMUST00000024627.2 ENSMUST00000024627.3 ENSMUST00000024627.4 ENSMUST00000024627.5 ENSMUST00000024627.6 ENSMUST00000024627.7 ENSMUST00000024627.8 ENSMUST00000024627.9 NM_007690 P40201 Q14BJ0 uc008aou.1 uc008aou.2 uc008aou.3 uc008aou.4 ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (By similarity). Required for maintaining open chromatin and pluripotency in embryonic stem cells (PubMed:19587682). Is also associated with histone deacetylase (HDAC) activity (PubMed:12890497). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Component of the SAGA complex (By similarity). Specifically interacts with methylated H3K4me2 and H3K4me3. Interacts with the FACT complex, the PAF complex and the U2 snRNP. Interacts directly with PAF1, SFA3A1, SFA3A2, SFA3A3, SNF2 and SSRP1 (By similarity). Interacts with BCLAF1, NCoR, SRP20 and SAFB. Nucleus toplasm Note=Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis (PubMed:7739555). Abundance is higher in cells representing early stages of the B-lymphoid lineage such as pre-B and B-cells, than in cells representing mature plasmacytes or other cell lineages such as fibroblasts. The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3). The CHD1 helical C-terminal domain (CHCT) binds DNA and nucleosomes. Belongs to the SNF2/RAD54 helicase family. nucleotide binding fibrillar center DNA binding DNA helicase activity chromatin binding helicase activity ATP binding nucleus cytoplasm chromatin organization chromatin assembly or disassembly chromatin remodeling covalent chromatin modification hydrolase activity DNA duplex unwinding methylated histone binding positive regulation by host of viral transcription uc008aou.1 uc008aou.2 uc008aou.3 uc008aou.4 
ENSMUST00000024657.12 Phf10 ENSMUST00000024657.12 PHD finger protein 10, transcript variant 1 (from RefSeq NM_024250.5) ENSMUST00000024657.1 ENSMUST00000024657.10 ENSMUST00000024657.11 ENSMUST00000024657.2 ENSMUST00000024657.3 ENSMUST00000024657.4 ENSMUST00000024657.5 ENSMUST00000024657.6 ENSMUST00000024657.7 ENSMUST00000024657.8 ENSMUST00000024657.9 K4DI61 K4DI61_MOUSE NM_024250 Phf10 uc029tag.1 uc029tag.2 uc029tag.3 uc029tag.4 Nucleus Belongs to the SAYP family. nucleus metal ion binding npBAF complex uc029tag.1 uc029tag.2 uc029tag.3 uc029tag.4 
ENSMUST00000024660.9 Smoc2 ENSMUST00000024660.9 SPARC related modular calcium binding 2 (from RefSeq NM_022315.2) ENSMUST00000024660.1 ENSMUST00000024660.2 ENSMUST00000024660.3 ENSMUST00000024660.4 ENSMUST00000024660.5 ENSMUST00000024660.6 ENSMUST00000024660.7 ENSMUST00000024660.8 NM_022315 Q8CD91 Q8VCM1 Q9D9K2 Q9ER95 SMOC2_MOUSE uc008amy.1 uc008amy.2 uc008amy.3 Can stimulate endothelial cell proliferation, migration, as well as angiogenesis (By similarity). Promotes matrix assembly and cell adhesiveness. Binds various proteins from the extracellular matrix. Secreted, extracellular space, extracellular matrix, basement membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CD91-1; Sequence=Displayed; Name=2; IsoId=Q8CD91-2; Sequence=VSP_008723; Strongly expressed in ovary, followed by heart, muscle, spleen, brain, thymus, lung, liver, kidney, spleen, testis, ovary and skeletal muscle. At 16.5 dpc, present in rib cartilage, choroid plexus epithelium and associated blood vessels, and developing oral and tooth germ epithelia (at protein level). N-glycosylated. calcium ion binding glycosaminoglycan binding extracellular region basement membrane interstitial matrix extracellular space heparin binding positive regulation of endothelial cell migration positive regulation of cell-substrate adhesion extracellular matrix organization extracellular matrix positive regulation of vascular wound healing positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of angiogenesis positive regulation of mitotic cell cycle metal ion binding cell periphery positive regulation of vascular endothelial growth factor signaling pathway positive regulation of DNA biosynthetic process positive regulation of endothelial cell chemotaxis uc008amy.1 uc008amy.2 uc008amy.3 
ENSMUST00000024696.9 Mmp25 ENSMUST00000024696.9 matrix metallopeptidase 25, transcript variant 2 (from RefSeq NM_001320258.2) ENSMUST00000024696.1 ENSMUST00000024696.2 ENSMUST00000024696.3 ENSMUST00000024696.4 ENSMUST00000024696.5 ENSMUST00000024696.6 ENSMUST00000024696.7 ENSMUST00000024696.8 MMP25_MOUSE NM_001320258 Q3U435 uc008asq.1 uc008asq.2 uc008asq.3 uc008asq.4 uc008asq.5 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded precursor undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]. May activate progelatinase A. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Cell membrane ; Lipid-anchor, GPI- anchor The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Belongs to the peptidase M10A family. In contrast to the human ortholog it does not have a signal sequence as it has an additional 53 residue sequence at the N-terminus. At the position of the human initiation methionine there is a leucine (Leu-54). metalloendopeptidase activity extracellular space plasma membrane proteolysis peptidase activity metallopeptidase activity zinc ion binding cell surface positive regulation of peptidase activity membrane integral component of membrane peptidase activator activity hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix anchored component of membrane metal ion binding hard palate development uc008asq.1 uc008asq.2 uc008asq.3 uc008asq.4 uc008asq.5 
ENSMUST00000024698.10 Tnfrsf12a ENSMUST00000024698.10 tumor necrosis factor receptor superfamily, member 12a, transcript variant 1 (from RefSeq NM_013749.2) ENSMUST00000024698.1 ENSMUST00000024698.2 ENSMUST00000024698.3 ENSMUST00000024698.4 ENSMUST00000024698.5 ENSMUST00000024698.6 ENSMUST00000024698.7 ENSMUST00000024698.8 ENSMUST00000024698.9 Fgfrp2 Fn14 NM_013749 Q3TVG8 Q9CR75 Q9QZW3 TNR12_MOUSE uc008asv.1 uc008asv.2 uc008asv.3 uc008asv.4 Receptor for TNFSF12/TWEAK (By similarity). Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. Membrane; Single-pass type I membrane protein. Highly expressed in fetal heart, intestine, kidney, liver, lung and skin, and in adult heart and ovary. Intermediate expression in adult kidney, lung and skin. By FGF-1. angiogenesis ruffle protein binding plasma membrane apoptotic process substrate-dependent cell migration, cell attachment to substrate cell adhesion multicellular organism development cell surface membrane integral component of membrane cell differentiation positive regulation of apoptotic process regulation of angiogenesis positive regulation of axon extension regulation of wound healing extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway uc008asv.1 uc008asv.2 uc008asv.3 uc008asv.4 
ENSMUST00000024699.4 Cldn6 ENSMUST00000024699.4 claudin 6, transcript variant 1 (from RefSeq NM_018777.5) CLD6_MOUSE ENSMUST00000024699.1 ENSMUST00000024699.2 ENSMUST00000024699.3 NM_018777 Q9Z262 uc008asw.1 uc008asw.2 uc008asw.3 uc008asw.4 uc008asw.5 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is essential for blastocyst formation in preimplantation mouse embryos, and is invloved in and is crucial for the formation and maintenance of the epidermal permeability barrier. This gene is adjacent to another family member Cldn9 on chromosome 17. [provided by RefSeq, Aug 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050138.1, AK010560.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (PubMed:10601346). Interacts with CLDN1, CD81 and OCLN (By similarity). Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Expressed mostly in embryonic tissues. Belongs to the claudin family. virus receptor activity structural molecule activity protein binding plasma membrane bicellular tight junction membrane integral component of membrane apicolateral plasma membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding cell-cell junction organization viral entry into host cell uc008asw.1 uc008asw.2 uc008asw.3 uc008asw.4 uc008asw.5 
ENSMUST00000024701.9 Pkmyt1 ENSMUST00000024701.9 protein kinase, membrane associated tyrosine/threonine 1, transcript variant 1 (from RefSeq NM_023058.4) ENSMUST00000024701.1 ENSMUST00000024701.2 ENSMUST00000024701.3 ENSMUST00000024701.4 ENSMUST00000024701.5 ENSMUST00000024701.6 ENSMUST00000024701.7 ENSMUST00000024701.8 Myt1 NM_023058 PMYT1_MOUSE Q3TNN2 Q8R3L4 Q9ESG9 uc008asz.1 uc008asz.2 uc008asz.3 Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Negatively regulated by hyperphosphorylation during mitosis. The hyperphosphorylated form does not associate with CCNB1-CDC2 complexes. The PLK1 protein kinase may be required for mitotic phosphorylation (By similarity). Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1 (By similarity). Endoplasmic reticulum membrane ; Peripheral membrane protein Golgi apparatus membrane ; Peripheral membrane protein The membrane-association motif is essential for the localization to membrane of Golgi stack. According to some authors, it is a transmembrane domain; the existence of a transmembrane region of such is however unsure (By similarity). Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2- CCNB1 complexes may inhibit the catalytic activity (By similarity). Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. Golgi membrane nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleolus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus protein phosphorylation cell cycle negative regulation of phosphatase activity membrane kinase activity phosphorylation transferase activity metal ion binding uc008asz.1 uc008asz.2 uc008asz.3 
ENSMUST00000024702.5 Paqr4 ENSMUST00000024702.5 progestin and adipoQ receptor family member IV (from RefSeq NM_023824.3) ENSMUST00000024702.1 ENSMUST00000024702.2 ENSMUST00000024702.3 ENSMUST00000024702.4 MNCb-0914 NM_023824 PAQR4_MOUSE Paqr4 Q3U7G1 Q9JJE4 uc008atb.1 uc008atb.2 uc008atb.3 Membrane ; Multi-pass membrane protein Belongs to the ADIPOR family. cellular_component membrane integral component of membrane signaling receptor activity uc008atb.1 uc008atb.2 uc008atb.3 
ENSMUST00000024704.10 Flywch2 ENSMUST00000024704.10 FLYWCH family member 2, transcript variant 1 (from RefSeq NM_029798.4) ENSMUST00000024704.1 ENSMUST00000024704.2 ENSMUST00000024704.3 ENSMUST00000024704.4 ENSMUST00000024704.5 ENSMUST00000024704.6 ENSMUST00000024704.7 ENSMUST00000024704.8 ENSMUST00000024704.9 FWCH2_MOUSE NM_029798 Q8R3N7 Q9CQE9 uc008atl.1 uc008atl.2 uc008atl.3 molecular_function cellular_component biological_process uc008atl.1 uc008atl.2 uc008atl.3 
ENSMUST00000024705.6 Slc25a27 ENSMUST00000024705.6 solute carrier family 25, member 27, transcript variant 1 (from RefSeq NM_028711.4) ENSMUST00000024705.1 ENSMUST00000024705.2 ENSMUST00000024705.3 ENSMUST00000024705.4 ENSMUST00000024705.5 NM_028711 Q9D6D0 Slc25a27 UCP4 UCP4_MOUSE uc008cpk.1 uc008cpk.2 uc008cpk.3 Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated. Reaction=H(+)(in) = H(+)(out); Xref=Rhea:RHEA:34979, ChEBI:CHEBI:15378; Evidence=; Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; Homotetramer. Mitochondrion inner membrane ; Multi-pass membrane protein Cell projection, neuron projection Note=Localizes to neuronal cell body and processes. Within mitochondrial inner membrane, it is mainly observed in the inner boundary membrane locally separated from F(1)F(0) ATP synthase, which is preferentially localized in cristae. Belongs to the mitochondrial carrier (TC 2.A.29) family. mitochondrion positive regulation of cell proliferation response to cold negative regulation of mitochondrial membrane potential membrane integral component of membrane mitochondrial membrane cellular triglyceride homeostasis neuronal cell body negative regulation of apoptotic process apical part of cell regulation of glucose import inner ear development negative regulation of mitochondrial calcium ion concentration neuron death uc008cpk.1 uc008cpk.2 uc008cpk.3 
ENSMUST00000024706.12 Pla2g7 ENSMUST00000024706.12 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma), transcript variant 1 (from RefSeq NM_013737.6) ENSMUST00000024706.1 ENSMUST00000024706.10 ENSMUST00000024706.11 ENSMUST00000024706.2 ENSMUST00000024706.3 ENSMUST00000024706.4 ENSMUST00000024706.5 ENSMUST00000024706.6 ENSMUST00000024706.7 ENSMUST00000024706.8 ENSMUST00000024706.9 NM_013737 PAFA_MOUSE Pafah Q60963 Q8BKM3 Q921T4 uc012atr.1 uc012atr.2 uc012atr.3 Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:10066756, PubMed:18434304). At the lipid- aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10066756, PubMed:18434304). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position. Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (By similarity). Hydrolyzes and inactivates platelet- activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3- phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed:10066756, PubMed:18434304). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in lipoprotein particles and uncontrolled pro-inflammatory effects (By similarity). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (By similarity). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (By similarity). Reaction=a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O- alkyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:17777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707; EC=3.1.1.47; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17778; Evidence=; Reaction=1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O- decyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:41376, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:78108, ChEBI:CHEBI:78109; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41377; Evidence=; Reaction=1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O- dodecyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:41372, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:78103, ChEBI:CHEBI:78104; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41373; Evidence=; Reaction=1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1- O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:41368, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:78101, ChEBI:CHEBI:78102; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41369; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1- O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:40479, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:44811, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40480; Evidence=; Reaction=1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1- O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:41183, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:52450, ChEBI:CHEBI:75216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41184; Evidence=; Reaction=1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:41203, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:72998, ChEBI:CHEBI:75219; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41204; Evidence=; Reaction=1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate; Xref=Rhea:RHEA:41191, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17272, ChEBI:CHEBI:72998, ChEBI:CHEBI:77831; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41192; Evidence=; Reaction=1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+); Xref=Rhea:RHEA:41195, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:72998, ChEBI:CHEBI:77832; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41196; Evidence=; Reaction=1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate; Xref=Rhea:RHEA:41199, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:31011, ChEBI:CHEBI:72998, ChEBI:CHEBI:77833; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41200; Evidence=; Reaction=1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+); Xref=Rhea:RHEA:41159, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30921, ChEBI:CHEBI:72998, ChEBI:CHEBI:77756; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41160; Evidence=; Reaction=1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+); Xref=Rhea:RHEA:40483, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16120, ChEBI:CHEBI:72998, ChEBI:CHEBI:77890; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40484; Evidence=; Reaction=1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+); Xref=Rhea:RHEA:41179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:61042, ChEBI:CHEBI:72998, ChEBI:CHEBI:77812; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41180; Evidence=; Reaction=1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn- glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3- phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+); Xref=Rhea:RHEA:41151, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:77753, ChEBI:CHEBI:77754; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41152; Evidence=; Reaction=1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero- 3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+); Xref=Rhea:RHEA:41155, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:77749, ChEBI:CHEBI:77755; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41156; Evidence=; Secreted, extracellular space Note=Associates with HDL particles in plasma. Plasma. N-glycosylated. Mutant mice show increased susceptibility to neonatal necrotizing enterocolitis in response to formula feeding, bacterial colonization, and asphyxia/ cold stress. Belongs to the AB hydrolase superfamily. Lipase family. Sequence=AAC52274.1; Type=Frameshift; Evidence=; 1-alkyl-2-acetylglycerophosphocholine esterase activity phospholipid binding extracellular region extracellular space cytoplasm lipid metabolic process inflammatory response lipid catabolic process hydrolase activity low-density lipoprotein particle low-density lipoprotein particle remodeling lipid oxidation plasma lipoprotein particle oxidation platelet activating factor metabolic process calcium-independent phospholipase A2 activity positive regulation of monocyte chemotaxis uc012atr.1 uc012atr.2 uc012atr.3 
ENSMUST00000024708.6 Tnfrsf21 ENSMUST00000024708.6 tumor necrosis factor receptor superfamily, member 21 (from RefSeq NM_178589.3) Dr6 ENSMUST00000024708.1 ENSMUST00000024708.2 ENSMUST00000024708.3 ENSMUST00000024708.4 ENSMUST00000024708.5 NM_178589 Q3UYG3 Q543Y9 Q91W77 Q91XH9 Q9EPU5 TNR21_MOUSE uc008cov.1 uc008cov.2 uc008cov.3 Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B (PubMed:11485735, PubMed:11714751, PubMed:12515813, PubMed:19225519, PubMed:21725297, PubMed:23559013). Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm (By similarity). Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning (PubMed:19225519). Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP) (PubMed:23559013). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) (PubMed:23559013). Negatively regulates oligodendrocyte survival, maturation and myelination (PubMed:21725297). Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation (By similarity). Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells (By similarity). Negatively regulates the production of IgG, IgM and IgM in response to antigens (By similarity). May inhibit the activation of JNK in response to T-cell stimulation (By similarity). Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (By similarity). Associates with TRADD (By similarity). Interacts with NGFR. Interacts with CASP8 (By similarity). Interacts with N-APP (PubMed:19225519). Cell membrane ; Single-pass type I membrane protein Note=Endocytosed following oxidation in response to reactive oxygen species (ROS). Detected in spleen B-cells (at protein level). Ubiquitous. Highly expressed in adult spleen, thymus, testis, prostate, ovary, small intestine, colon, brain, lung and kidney, and in fetal brain, liver and lung. Detected at lower levels in adult peripheral blood leukocytes, lung, and in fetal muscle, heart, kidney, small intestine and skin. Detected in T-cells, B-cells and monocytes. In T- cells expression is highest in Th0 cells, intermediate in Th2 cells and lower in Th1 cells. Expressed at low levels in proliferating progenitors in the spinal cord, but is highly expressed by differentiating neurons within the spinal cord and adjacent dorsal root ganglia. Expressed by developing neurons as they differentiate and enter a pro-apoptotic state. Expressed by both cell bodies and axons. Oxidized in response to reactive oxygen species (ROS), leading to endocytosis. No visible phenotype. Mice are born at the expected Mendelian rate, are viable and fertile. Mutant mice display an increased number of T-cells in the peripheral blood, but only a minor increase of the number of T-cells in spleen and thymus. T-cells from mutant mice show increased proliferative responses to antigens and produce higher levels of IL4, IL5, IL10, IL13 and IFNG. Mutant mice have normal serum levels of IgG and IgM in the absence of antigen, but produce higher levels of IgG, IgM and IgM in response to antigens. Likewise, B-cells from mutant mice display increased proliferation and decreased apoptosis in response to antigens. Mutant mice show increased levels of mature oligodendrocytes, decreased levels of apoptotic oligodendrocytes and increased myelination. Mutant mice are not susceptible to neuronal apoptosis triggered by exposure to amyloid peptides derived from APP. It is uncertain whether Met-1 or Met-25 is the initiator. B cell apoptotic process adaptive immune response immune system process cytoplasm plasma membrane integral component of plasma membrane apoptotic process humoral immune response signal transduction axonal fasciculation membrane integral component of membrane axon negative regulation of B cell proliferation intrinsic component of plasma membrane negative regulation of myelination negative regulation of T cell proliferation myelination regulation of oligodendrocyte differentiation T cell receptor signaling pathway neuron apoptotic process cellular response to tumor necrosis factor oligodendrocyte apoptotic process negative regulation of interleukin-5 secretion negative regulation of interleukin-13 secretion negative regulation of interleukin-10 secretion uc008cov.1 uc008cov.2 uc008cov.3 
ENSMUST00000024709.9 Cd2ap ENSMUST00000024709.9 CD2-associated protein, transcript variant 5 (from RefSeq NR_177075.1) CD2AP_MOUSE E9QL86 ENSMUST00000024709.1 ENSMUST00000024709.2 ENSMUST00000024709.3 ENSMUST00000024709.4 ENSMUST00000024709.5 ENSMUST00000024709.6 ENSMUST00000024709.7 ENSMUST00000024709.8 Mets1 NR_177075 O88903 Q8K4Z1 Q8VCI9 Q9JLQ0 uc008cot.1 uc008cot.2 uc008cot.3 Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (By similarity). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen- presenting cell (PubMed:9741631). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus (PubMed:10514378). Also required for cytokinesis. Plays a role in epithelial cell junctions formation (By similarity). Homodimer. Interacts with F-actin, PKD2, NPHS1 and NPHS2. Interacts with WTIP. Interacts with DDN; interaction is direct. Interacts (via SH3 2 domain) with CBL (via phosphorylated C-terminus). Interacts with BCAR1/p130Cas (via SH3 domain). Interacts with MVB12A and ARHGAP17. Interacts with ANLN, CD2 and CBLB. Interacts with PDCD6IP and TSG101. Interacts with RIN3. Interacts directly with RET (inactive) and CBLC; upon RET activation by GDNF suggested to dissociate from RET as CBLC:CD2AP complex. Interacts with CGNL1 and SH3BP1; probably part of a complex at cell junctions. Interacts with CAPZA1. Q9JLQ0; P22682: Cbl; NbExp=5; IntAct=EBI-644807, EBI-640919; Cytoplasm, cytoskeleton Cell projection, ruffle Cell junction Note=Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles (By similarity). Located at podocyte slit diaphragm between podocyte foot processes (PubMed:10514378, PubMed:11733379). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase (By similarity). Expressed in podocytes (at protein level). Potential homodimerization is mediated by the coiled coil domain. Phosphorylated on tyrosine residues; probably by c-Abl, Fyn and c- Src. Death at 6 to 7 weeks of age from renal failure. Mice show defects in epithelial foot processes, accompanied by mesangial cell hyperplasia and extracellular matrix deposition. ruffle vascular endothelial growth factor receptor binding protein binding cytoplasm cytosol cytoskeleton plasma membrane cell-cell junction cell cortex actin filament organization cell cycle beta-catenin binding protein C-terminus binding vesicle organization cell migration SH3 domain binding cell junction endocytic vesicle cell leading edge filamentous actin negative regulation of transforming growth factor beta1 production macromolecular complex identical protein binding cell projection proteasome-mediated ubiquitin-dependent protein catabolic process macromolecular complex binding cadherin binding regulation of receptor-mediated endocytosis perinuclear region of cytoplasm positive regulation of protein secretion negative regulation of small GTPase mediated signal transduction cell division cell-cell adhesion positive regulation of protein localization to nucleus regulation of actin cytoskeleton reorganization uc008cot.1 uc008cot.2 uc008cot.3 
ENSMUST00000024711.11 Adgrf4 ENSMUST00000024711.11 adhesion G protein-coupled receptor F4, transcript variant 1 (from RefSeq NM_030067.2) A0A0D9SEG9 A0A0D9SEG9_MOUSE Adgrf4 ENSMUST00000024711.1 ENSMUST00000024711.10 ENSMUST00000024711.2 ENSMUST00000024711.3 ENSMUST00000024711.4 ENSMUST00000024711.5 ENSMUST00000024711.6 ENSMUST00000024711.7 ENSMUST00000024711.8 ENSMUST00000024711.9 NM_030067 uc008cor.1 uc008cor.2 uc008cor.3 uc008cor.4 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. transmembrane signaling receptor activity G-protein coupled receptor activity cell surface receptor signaling pathway G-protein coupled receptor signaling pathway membrane integral component of membrane uc008cor.1 uc008cor.2 uc008cor.3 uc008cor.4 
ENSMUST00000024717.10 Tbc1d5 ENSMUST00000024717.10 TBC1 domain family, member 5, transcript variant 2 (from RefSeq NM_028162.4) E9PZJ9 ENSMUST00000024717.1 ENSMUST00000024717.2 ENSMUST00000024717.3 ENSMUST00000024717.4 ENSMUST00000024717.5 ENSMUST00000024717.6 ENSMUST00000024717.7 ENSMUST00000024717.8 ENSMUST00000024717.9 NM_028162 Q80XQ2 TBCD5_MOUSE uc008cyy.1 uc008cyy.2 uc008cyy.3 uc008cyy.4 uc008cyy.5 May act as a GTPase-activating protein for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (By similarity). Interacts with MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1, GABARAPL2. Interacts with VPS29 and VPS35; indicative for an association with retromer CSC subcomplex. MAP1LC3A and VPS29 compete for binding to TBC1D5. Interacts with AP2M1; indicative for an association with the AP2 complex. Interacts with ULK1 and ATG13 (phosphorylated); indicative for an association with the activated ULK1-ATG13-FIP200 complex. Interacts with ATG9A; the interactions seems to be restricted to the AP2-clathrin-associated fraction of ATG9A. Endosome membrane Cytoplasmic vesicle, autophagosome Note=During starvation induced autophagy is relocalized from endosomal localization to LC3-positive autophagosomes (By similarity). The arginine and glutamine fingers are critical for the GTPase- activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site. The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins. LIR 1 is also implicated in interaction with retromer; LIR 2 is only implicated in interaction with ATG8 family proteins. positive regulation of receptor internalization GTPase activator activity endosome autophagosome Golgi apparatus cytosol intracellular protein transport autophagy endosome membrane protein transport membrane macroautophagy Rab GTPase binding AP-2 adaptor complex retromer complex cytoplasmic vesicle AP-2 adaptor complex binding retrograde transport, endosome to Golgi response to starvation intracellular membrane-bounded organelle macromolecular complex binding activation of GTPase activity retromer complex binding ATG1/ULK1 kinase complex uc008cyy.1 uc008cyy.2 uc008cyy.3 uc008cyy.4 uc008cyy.5 
ENSMUST00000024721.8 Rhag ENSMUST00000024721.8 Rhesus blood group-associated A glycoprotein (from RefSeq NM_011269.2) ENSMUST00000024721.1 ENSMUST00000024721.2 ENSMUST00000024721.3 ENSMUST00000024721.4 ENSMUST00000024721.5 ENSMUST00000024721.6 ENSMUST00000024721.7 NM_011269 Q3UP27 Q794G1 Q9QUT0 RHAG_MOUSE Rh50 Rhag uc008col.1 uc008col.2 uc008col.3 Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Heterotrimer with RHCE (RHAG)2(RHCE), that transports ammonium and its related derivative methylammonium, in both neutral and ionic forms, across the erythrocyte membrane (PubMed:19807729). The transport of NH4(+) is electrogenic and masks the NH3 transport. Also, may act as a CO2 channel. Moreover in erythrocyte, regulates RHD membrane expression and is associated with rhesus blood group antigen expression (By similarity). Reaction=methylamine(out) = methylamine(in); Xref=Rhea:RHEA:74391, ChEBI:CHEBI:59338; Evidence=; Reaction=NH4(+)(in) = NH4(+)(out); Xref=Rhea:RHEA:28747, ChEBI:CHEBI:28938; Evidence=; Reaction=CO2(out) = CO2(in); Xref=Rhea:RHEA:74891, ChEBI:CHEBI:16526; Evidence=; Homodimer. Heterotrimer; a RHCE monomer interacts with a RHAG homodimer. Component of the ankyrin-1 complex in the erythrocyte, composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1. Interacts with GYPB (via the N-terminal); this interaction bridges the (RHAG)2(RHCE) heterotrimer with the SLC4A1 Band 3 I dimer complexed with GYPA. Membrane ; Multi- pass membrane protein Note=Localization at the plasma membrane is regulated by ANK1. Glycosylated. Homozygous knockout mice lacking Rhag exhibit normal growth, development and fertility (PubMed:16581281, PubMed:19807729). Mice exhibit no significant change in body weight and body mass index (PubMed:19807729). Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. plasma membrane integral component of plasma membrane cellular ion homeostasis ammonium transmembrane transporter activity carbon dioxide transport monovalent inorganic cation transport ammonium transport membrane integral component of membrane leak channel activity ankyrin binding erythrocyte development multicellular organismal iron ion homeostasis ammonium transmembrane transport uc008col.1 uc008col.2 uc008col.3 
ENSMUST00000024725.5 Efhb ENSMUST00000024725.5 EF hand domain family, member B (from RefSeq NM_172497.3) A2RSG9 Cfap21 EFHB_MOUSE ENSMUST00000024725.1 ENSMUST00000024725.2 ENSMUST00000024725.3 ENSMUST00000024725.4 Efhb NM_172497 Q8CDU5 uc008czl.1 uc008czl.2 Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion and the activation of store- operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus (By similarity). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Interacts with STIM1 and ORAI1; the interactions take place upon Ca(2+)-store depletion and dissociate through a Ca(2+)-dependent mechanism. Interaction with STIM1 inhibits STIM1 interaction with SARAF. Cytoplasm Cytoplasm, cytoskeleton, cilium axoneme calcium ion binding cellular_component cytoplasm negative regulation of protein binding metal ion binding regulation of calcineurin-NFAT signaling cascade regulation of store-operated calcium entry uc008czl.1 uc008czl.2 
ENSMUST00000024727.10 Cdc5l ENSMUST00000024727.10 cell division cycle 5-like (from RefSeq NM_152810.2) CDC5L_MOUSE ENSMUST00000024727.1 ENSMUST00000024727.2 ENSMUST00000024727.3 ENSMUST00000024727.4 ENSMUST00000024727.5 ENSMUST00000024727.6 ENSMUST00000024727.7 ENSMUST00000024727.8 ENSMUST00000024727.9 Kiaa0432 NM_152810 Q6A068 Q8K1J9 uc008cqj.1 uc008cqj.2 uc008cqj.3 uc008cqj.4 uc008cqj.5 DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Homodimer. Interacts with DAPK3 (By similarity). Component of the precatalytic, catalytic and postcatalytic spliceosome complexes (By similarity). Part of a spliceosomal 'core' complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 and CCAP6. Interacts with PLRG1, Lodestar/TTF2, and NIPP1/PPP1R8. Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with SCNM1 (By similarity). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its C-terminus) directly in the complex with PRPF19 and BCAS2. Interacts (via its C-terminus) directly with PRGL1 (via its WD40 repeat domain); the interaction is required for mRNA splicing but not for spliceosome assembly. Also interacts with CTNNBL1. Interacts with PRPF19 (via N-terminus) (By similarity). Interacts with USB1 (By similarity). Nucleus cleus speckle toplasm Note=May shuttle between cytoplasm and nucleus. Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8. Belongs to the CEF1 family. Sequence=BAD32228.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; mitotic cell cycle mRNA splicing, via spliceosome Prp19 complex RNA polymerase II regulatory region sequence-specific DNA binding transcription corepressor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding RNA binding nucleus nucleoplasm spliceosomal complex cytoplasm DNA repair mRNA processing cellular response to DNA damage stimulus cell cycle protein phosphatase 1 binding RNA splicing nuclear speck protein kinase binding protein-DNA complex leucine zipper domain binding positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome WD40-repeat domain binding signal transduction involved in DNA damage checkpoint cellular response to wortmannin cellular response to nerve growth factor stimulus DNA replication factor A complex uc008cqj.1 uc008cqj.2 uc008cqj.3 uc008cqj.4 uc008cqj.5 
ENSMUST00000024731.9 Spats1 ENSMUST00000024731.9 spermatogenesis associated, serine-rich 1, transcript variant 1 (from RefSeq NM_027649.3) A2RRY8 Ddip ENSMUST00000024731.1 ENSMUST00000024731.2 ENSMUST00000024731.3 ENSMUST00000024731.4 ENSMUST00000024731.5 ENSMUST00000024731.6 ENSMUST00000024731.7 ENSMUST00000024731.8 NM_027649 Q6VNB9 Q9CUD9 Q9DAG2 SPAS1_MOUSE uc008cqp.1 uc008cqp.2 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2RRY8-1; Sequence=Displayed; Name=2; IsoId=A2RRY8-2; Sequence=VSP_028789; Name=3; IsoId=A2RRY8-3; Sequence=VSP_028788, VSP_028789; molecular_function cellular_component biological_process uc008cqp.1 uc008cqp.2 
ENSMUST00000024733.9 Aars2 ENSMUST00000024733.9 alanyl-tRNA synthetase 2, mitochondrial, transcript variant 1 (from RefSeq NM_198608.2) Aarsl ENSMUST00000024733.1 ENSMUST00000024733.2 ENSMUST00000024733.3 ENSMUST00000024733.4 ENSMUST00000024733.5 ENSMUST00000024733.6 ENSMUST00000024733.7 ENSMUST00000024733.8 Gm89 Kiaa1270 NM_198608 Q14CH7 Q68FH3 Q69ZM9 SYAM_MOUSE uc008cqr.1 uc008cqr.2 Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Reaction=ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl- tRNA(Ala); Xref=Rhea:RHEA:12540, Rhea:RHEA-COMP:9657, Rhea:RHEA- COMP:9923, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57972, ChEBI:CHEBI:78442, ChEBI:CHEBI:78497, ChEBI:CHEBI:456215; EC=6.1.1.7; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Monomer. Mitochondrion. Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs. Belongs to the class-II aminoacyl-tRNA synthetase family. tRNA binding nucleotide binding aminoacyl-tRNA editing activity nucleic acid binding RNA binding aminoacyl-tRNA ligase activity alanine-tRNA ligase activity ATP binding cytoplasm mitochondrion tRNA modification translation alanyl-tRNA aminoacylation zinc ion binding amino acid binding ligase activity tRNA aminoacylation metal ion binding mitochondrial alanyl-tRNA aminoacylation uc008cqr.1 uc008cqr.2 
ENSMUST00000024734.8 Mrpl14 ENSMUST00000024734.8 mitochondrial ribosomal protein L14 (from RefSeq NM_026732.3) ENSMUST00000024734.1 ENSMUST00000024734.2 ENSMUST00000024734.3 ENSMUST00000024734.4 ENSMUST00000024734.5 ENSMUST00000024734.6 ENSMUST00000024734.7 NM_026732 Q3UNL3 Q9D1I6 RM14_MOUSE uc008crj.1 uc008crj.2 uc008crj.3 May form part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1, intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation. Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with MALSU1. Mitochondrion Belongs to the universal ribosomal protein uL14 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation uc008crj.1 uc008crj.2 uc008crj.3 
ENSMUST00000024736.14 Sgo1 ENSMUST00000024736.14 shugoshin 1 (from RefSeq NM_028232.2) ENSMUST00000024736.1 ENSMUST00000024736.10 ENSMUST00000024736.11 ENSMUST00000024736.12 ENSMUST00000024736.13 ENSMUST00000024736.2 ENSMUST00000024736.3 ENSMUST00000024736.4 ENSMUST00000024736.5 ENSMUST00000024736.6 ENSMUST00000024736.7 ENSMUST00000024736.8 ENSMUST00000024736.9 NM_028232 Q3U4K4 Q588H1 Q8BKW2 Q9CXH7 SGO1_MOUSE Sgo1 Sgol1 uc008czq.1 uc008czq.2 uc008czq.3 uc008czq.4 Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Involved in centromeric enrichment of AUKRB in prometaphase. Interacts with PPP2CA (or PPP2CB), PPP2R1B, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E, SET, LRRC59, RBM10 (or RBM5), RPL10A, RPL28, RPL7, RPL7A and RPLP1. Interaction with protein phosphatase 2A occurs most probably through direct binding to the regulatory B56 subunits: PPP2R1B, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E. Interacts with PPP2R1A and NEK2. Interacts with CDCA8 (By similarity). Nucleus Chromosome, centromere Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase. Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A. Colocalizes with NEK2 at the kinetochore. Colocalizes with and SS18L1 at the kinetochore. Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore. Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not appear to be associated with kinetochores during late mitosis. Isoform 3 is found at the centrosome in interphase and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent. Isoform 3 does not localize to kinetochores during any stages of the cell cycle. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=1A; IsoId=Q9CXH7-1; Sequence=Displayed; Name=2; Synonyms=1B; IsoId=Q9CXH7-2; Sequence=VSP_016796, VSP_016797; Ubiquitously expressed in proliferating cells. Moderately expressed in the oocytes. Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1. Phosphorylation by NEK2 is essential for chromosome congression in mitosis and for the proper attachment of spindle microtubule to the kinetochore. Phosphorylated by PLK1 and AUKRB (By similarity). Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin). Belongs to the shugoshin family. chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed chromosome, centromeric region condensed nuclear chromosome, centromeric region spindle pole nucleus nucleoplasm chromosome cytoplasm centrosome microtubule organizing center cytosol cytoskeleton cell cycle chromosome segregation attachment of spindle microtubules to kinetochore centriole-centriole cohesion kinase binding meiotic chromosome segregation cell division mitotic sister chromatid cohesion, centromeric uc008czq.1 uc008czq.2 uc008czq.3 uc008czq.4 
ENSMUST00000024738.8 Sult1c1 ENSMUST00000024738.8 sulfotransferase family, cytosolic, 1C, member 1 (from RefSeq NM_018751.2) ENSMUST00000024738.1 ENSMUST00000024738.2 ENSMUST00000024738.3 ENSMUST00000024738.4 ENSMUST00000024738.5 ENSMUST00000024738.6 ENSMUST00000024738.7 NM_018751 O70262 Q80VR3 ST1C1_MOUSE Sult1a2 Sult1c1 uc008czv.1 uc008czv.2 uc008czv.3 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). Also shows activity towards cinnamyl alcohol at pH 6.4 but not at pH 5.5, and towards a number of phenolic odorants including eugenol, guaiacol and 2-naphthol. Inhibited by 2,6-dichloro-4-nitrophenol but not by triethylamine or tetra-n-butyl-ammonium chloride. Kinetic parameters: KM=3.36 uM for 2-naphthol ; KM=3.15 uM for guaiacol ; KM=2.60 uM for N-hydroxy-2-acetylamino-fluorene ; Vmax=36.1 nmol/min/mg enzyme toward 2-naphthol ; Vmax=40.7 nmol/min/mg enzyme toward guaiacol ; Vmax=0.709 nmol/min/mg enzyme toward N-hydroxy-2-acetylamino-fluorene ; Cytoplasm Expressed only in olfactory tissue. Detected in sustentacular cells in the dorso-medial portion of the nasal cavity. Belongs to the sulfotransferase 1 family. alcohol sulfotransferase activity aryl sulfotransferase activity cytoplasm sulfur compound metabolic process sulfotransferase activity transferase activity uc008czv.1 uc008czv.2 uc008czv.3 
ENSMUST00000024739.14 Hsp90ab1 ENSMUST00000024739.14 heat shock protein 90 alpha (cytosolic), class B member 1 (from RefSeq NM_008302.3) ENSMUST00000024739.1 ENSMUST00000024739.10 ENSMUST00000024739.11 ENSMUST00000024739.12 ENSMUST00000024739.13 ENSMUST00000024739.2 ENSMUST00000024739.3 ENSMUST00000024739.4 ENSMUST00000024739.5 ENSMUST00000024739.6 ENSMUST00000024739.7 ENSMUST00000024739.8 ENSMUST00000024739.9 Hsp84b Hsp90ab1 Hspcb NM_008302 Q71LX8 Q71LX8_MOUSE uc008cqz.1 uc008cqz.2 uc008cqz.3 Dynein axonemal particle Melanosome Belongs to the heat shock protein 90 family. UTP binding CTP binding double-stranded RNA binding ATP binding GTP binding extracellular region nucleus cytoplasm lysosomal membrane cytosol protein folding telomere maintenance via telomerase drug binding COP9 signalosome response to salt stress cell surface inclusion body basolateral plasma membrane apical plasma membrane sulfonylurea receptor binding virion attachment to host cell kinase binding positive regulation of transforming growth factor beta receptor signaling pathway heat shock protein binding regulation of protein ubiquitination brush border membrane ubiquitin protein ligase binding positive regulation of protein binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of phosphoprotein phosphatase activity dATP binding macromolecular complex aryl hydrocarbon receptor complex cellular response to drug response to cocaine peptide binding response to drug identical protein binding protein homodimerization activity histone deacetylase binding ATP-dependent protein binding negative regulation of neuron apoptotic process ion channel binding positive regulation of cell differentiation positive regulation of cell size protein dimerization activity unfolded protein binding chaperone-mediated protein complex assembly negative regulation of protein metabolic process positive regulation of telomerase activity regulation of interferon-gamma-mediated signaling pathway regulation of type I interferon-mediated signaling pathway DNA polymerase binding negative regulation of cell cycle arrest cellular response to organic cyclic compound positive regulation of protein serine/threonine kinase activity supramolecular fiber organization disordered domain specific binding negative regulation of transforming growth factor beta activation negative regulation of proteasomal protein catabolic process negative regulation of complement-dependent cytotoxicity positive regulation of cyclin-dependent protein kinase activity telomerase holoenzyme complex assembly histone methyltransferase binding HSP90-CDC37 chaperone complex sperm head plasma membrane ooplasm positive regulation of protein localization to cell surface uc008cqz.1 uc008cqz.2 uc008cqz.3 
ENSMUST00000024742.9 Nfkbie ENSMUST00000024742.9 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon, transcript variant 1 (from RefSeq NM_008690.4) ENSMUST00000024742.1 ENSMUST00000024742.2 ENSMUST00000024742.3 ENSMUST00000024742.4 ENSMUST00000024742.5 ENSMUST00000024742.6 ENSMUST00000024742.7 ENSMUST00000024742.8 IKBE_MOUSE Ikbe NM_008690 O54910 Q3U686 Q9CZZ9 Q9D7U3 uc008cqv.1 uc008cqv.2 uc008cqv.3 uc008cqv.4 uc008cqv.5 Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes (By similarity). Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. O54910; O08749: Dld; NbExp=4; IntAct=EBI-6688774, EBI-773199; O54910; Q04863: Relb; NbExp=2; IntAct=EBI-6688774, EBI-1209145; Cytoplasm. Serine phosphorylated; followed by proteasome-dependent degradation. Belongs to the NF-kappa-B inhibitor family. fibrillar center protein binding nucleus cytoplasm Golgi apparatus cytosol D-serine transport negative regulation of transcription, DNA-templated perinuclear region of cytoplasm uc008cqv.1 uc008cqv.2 uc008cqv.3 uc008cqv.4 uc008cqv.5 
ENSMUST00000024748.14 Gtpbp2 ENSMUST00000024748.14 GTP binding protein 2, transcript variant 12 (from RefSeq NR_176958.1) ENSMUST00000024748.1 ENSMUST00000024748.10 ENSMUST00000024748.11 ENSMUST00000024748.12 ENSMUST00000024748.13 ENSMUST00000024748.2 ENSMUST00000024748.3 ENSMUST00000024748.4 ENSMUST00000024748.5 ENSMUST00000024748.6 ENSMUST00000024748.7 ENSMUST00000024748.8 ENSMUST00000024748.9 GTPB2_MOUSE Gtpbp2 NR_176958 Q3UJK4 Q9EST7 Q9JIX7 uc008crw.1 uc008crw.2 uc008crw.3 Q3UJK4; Q80X73: Pelo; NbExp=3; IntAct=EBI-16114877, EBI-16114899; Predominantly expressed in thymus, spleen, and testis. Expressed at lower levels in brain, heart, lung, kidney, and skeletal muscle. In testis, specifically expressed in spermatocytes and round spermatids. Up-regulated in thioglycolate-elicited mouse peritoneal macrophages. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily. Sequence=AAF78885.1; Type=Erroneous initiation; Evidence=; Sequence=AAH49089.1; Type=Erroneous initiation; Evidence=; Sequence=AAH51958.1; Type=Erroneous initiation; Evidence=; Sequence=BAB12430.1; Type=Erroneous initiation; Evidence=; nucleotide binding translation elongation factor activity GTPase activity protein binding GTP binding translational elongation intracellular membrane-bounded organelle uc008crw.1 uc008crw.2 uc008crw.3 
ENSMUST00000024749.9 Polh ENSMUST00000024749.9 polymerase (DNA directed), eta (RAD 30 related), transcript variant 1 (from RefSeq NM_030715.4) ENSMUST00000024749.1 ENSMUST00000024749.2 ENSMUST00000024749.3 ENSMUST00000024749.4 ENSMUST00000024749.5 ENSMUST00000024749.6 ENSMUST00000024749.7 ENSMUST00000024749.8 NM_030715 POLH_MOUSE Q9JJJ2 Q9JJN0 Rad30a Xpv uc008crx.1 uc008crx.2 uc008crx.3 DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10871396). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2- intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (By similarity). Particularly important for the repair of UV- induced pyrimidine dimers (PubMed:10871396). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis. Targets POLI to replication foci (By similarity). Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 Mg(2+). Prefers Mg(2+), but can also use Mn(2+). In vitro, can also utilize other divalent cations such as Ca(2+). ; The enzyme in complex with the DNA substrate binds a third divalent metal cation. The binding of this third divalent cation, which is coordinated by water molecules and two oxygen atoms from DNA and dNTP, is essential for catalyzing the DNA synthesis. Interacts with REV1 (PubMed:14657033). Interacts with monoubiquitinated PCNA, but not unmodified PCNA (By similarity). Interacts with POLI; this interaction targets POLI to the replication machinery (By similarity). Interacts with PALB2 and BRCA2; the interactions are direct and are required to sustain the recruitment of POLH at blocked replication forks and to stimulate POLH-dependent DNA synthesis on D loop substrates (By similarity). Interacts (via C- terminus) with TRAIP. Interacts with ubiquitin (By similarity). Interacts with POLDIP2. Nucleus Note=Binding to ubiquitinated PCNA mediates colocalization to replication foci during DNA replication and persists at sites of stalled replication forks following UV irradiation. After UV irradiation, recruited to DNA damage sites within 1 hour, to a maximum of about 80%; this recruitment may not be not restricted to cells active in DNA replication. Colocalizes with TRAIP to nuclear foci. Ubiquitous. Up-regulated in proliferating cultured fibroblasts. The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity. The UBZ3-type zinc finger domain and the PIP-box mediate the interaction with ubiquitinated PCNA and are both necessary for the enzymatic activity in translesion synthesis. Monoubiquitinated by RCHY1/PIRH2. Ubiquitination depends on integrity of the UBZ3-type zinc finger domain and is enhanced by TRAIP. Ubiquitination inhibits the ability of PolH to interact with PCNA and to bypass UV-induced lesions. Belongs to the DNA polymerase type-Y family. DNA synthesis involved in DNA repair DNA binding damaged DNA binding DNA-directed DNA polymerase activity nucleus nucleoplasm replication fork cytosol DNA replication DNA repair pyrimidine dimer repair postreplication repair cellular response to DNA damage stimulus response to radiation response to UV-C transferase activity nucleotidyltransferase activity site of double-strand break error-prone translesion synthesis metal ion binding cellular response to UV-C DNA biosynthetic process uc008crx.1 uc008crx.2 uc008crx.3 
ENSMUST00000024755.7 Clic5 ENSMUST00000024755.7 chloride intracellular channel 5 (from RefSeq NM_172621.2) CLIC5_MOUSE ENSMUST00000024755.1 ENSMUST00000024755.2 ENSMUST00000024755.3 ENSMUST00000024755.4 ENSMUST00000024755.5 ENSMUST00000024755.6 NM_172621 Q3U0H8 Q8BXK9 uc008cpw.1 uc008cpw.2 uc008cpw.3 Required for normal hearing (By similarity). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:17021174). Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (PubMed:29425878). Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, and IQGAP1. Interacts with AKAP9 (By similarity). Golgi apparatus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton Cytoplasm, cell cortex Membrane ; Single-pass membrane protein Apical cell membrane ; Single-pass membrane protein Cytoplasm Mitochondrion Note=Colocalized with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome (By similarity). Associates with the cortical actin cytoskeleton (By similarity). Localizes to the apical region of cochlear hair cells, at the base of the actin-rich hair bundle (PubMed:17021174). Colocalizes with podocalyxin at the apical cell membrane in renal glomeruli (By similarity). May localize to the centrosome in lens epithelial cells (PubMed:29425878). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). Detected in lung and inner ear. Detected in embryonic cochlea, on microvilli-covered apical surfaces of interdental cells, columnar cells of Kolliker's organ, and on stereocilia of inner and outer hair cells (at protein level) (PubMed:17021174). Also detected in the eye, where it localizes to lens fiber cells in the lens epithelium (at protein level) (PubMed:29425878). Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as a chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity). Note=Defects in Clic5 are a cause of the jitterbug (jbg) phenotype. Jbg is the result of a spontaneous mutation that leads to severe degeneration of the organ of Corti in the inner ear. Jbg leads to progressive degeneration of inner ear hair cells. Affected mice are identified by head bobbing, circling behavior and their inability to swim. They cannot hear well when young, and become completely deaf after 5 months (PubMed:17021174). In addition, there are eye defects with aberrant development of the lens suture and formation of lens opacities (PubMed:29425878). Belongs to the chloride channel CLIC family. response to dietary excess diet induced thermogenesis voltage-gated ion channel activity chloride channel activity nucleus cytoplasm Golgi apparatus microtubule organizing center cytoskeleton plasma membrane cell cortex ion transport chloride transport visual perception sensory perception of sound protein localization actin cytoskeleton membrane integral component of membrane apical plasma membrane stereocilium stereocilium bundle ion transmembrane transport chloride channel complex regulation of ion transmembrane transport neuromuscular process controlling balance response to stimulus auditory receptor cell stereocilium organization chloride transmembrane transport uc008cpw.1 uc008cpw.2 uc008cpw.3 
ENSMUST00000024757.14 Enpp4 ENSMUST00000024757.14 ectonucleotide pyrophosphatase/phosphodiesterase 4, transcript variant 1 (from RefSeq NM_199016.2) ENPP4_MOUSE ENSMUST00000024757.1 ENSMUST00000024757.10 ENSMUST00000024757.11 ENSMUST00000024757.12 ENSMUST00000024757.13 ENSMUST00000024757.2 ENSMUST00000024757.3 ENSMUST00000024757.4 ENSMUST00000024757.5 ENSMUST00000024757.6 ENSMUST00000024757.7 ENSMUST00000024757.8 ENSMUST00000024757.9 Kiaa0879 NM_199016 Q3TZS2 Q69ZX0 Q8BTJ4 Q8K1L3 uc008cpv.1 uc008cpv.2 uc008cpv.3 uc008cpv.4 Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors (By similarity). Reaction=H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate = ADP + AMP + 2 H(+); Xref=Rhea:RHEA:13893, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58529, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=3.6.1.29; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Cell membrane ; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BTJ4-1; Sequence=Displayed; Name=2; IsoId=Q8BTJ4-2; Sequence=VSP_032370; Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. Sequence=BAD32326.1; Type=Erroneous initiation; Evidence=; catalytic activity plasma membrane blood coagulation hemostasis membrane integral component of membrane hydrolase activity positive regulation of blood coagulation purine ribonucleoside catabolic process metal ion binding bis(5'-adenosyl)-triphosphatase activity uc008cpv.1 uc008cpv.2 uc008cpv.3 uc008cpv.4 
ENSMUST00000024761.13 Fbxl17 ENSMUST00000024761.13 F-box and leucine-rich repeat protein 17 (from RefSeq NM_015794.1) B2RRC1 ENSMUST00000024761.1 ENSMUST00000024761.10 ENSMUST00000024761.11 ENSMUST00000024761.12 ENSMUST00000024761.2 ENSMUST00000024761.3 ENSMUST00000024761.4 ENSMUST00000024761.5 ENSMUST00000024761.6 ENSMUST00000024761.7 ENSMUST00000024761.8 ENSMUST00000024761.9 FXL17_MOUSE Fbl17 Fbx13 Fbxl17 Fbxo13 NM_015794 Q8BTC3 Q9QZN1 uc008dfl.1 uc008dfl.2 uc008dfl.3 uc008dfl.4 uc008dfl.5 Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome (By similarity). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (By similarity). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (PubMed:28883095). Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL17) composed of CUL1, SKP1, RBX1 and FBXL17. Interacts with BTB domain-containing proteins such as KLHL12, BCL6 and BACH1; specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition. Interacts with SUFU (By similarity). Interacts with PRMT1 (PubMed:28883095). Cytoplasm Nucleus Note=Present in the cytoplasm and nucleus; more abundant in the cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QZN1-1; Sequence=Displayed; Name=2; IsoId=Q9QZN1-2; Sequence=VSP_009477, VSP_009478; Belongs to the FBXL17 family. protein polyubiquitination nucleus cytoplasm misfolded or incompletely synthesized protein catabolic process nervous system development regulation of smoothened signaling pathway neural crest cell differentiation protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process uc008dfl.1 uc008dfl.2 uc008dfl.3 uc008dfl.4 uc008dfl.5 
ENSMUST00000024762.3 Rsph9 ENSMUST00000024762.3 radial spoke head 9 homolog (Chlamydomonas) (from RefSeq NM_029338.4) ENSMUST00000024762.1 ENSMUST00000024762.2 NM_029338 Q9D9V4 RSPH9_MOUSE uc008crt.1 uc008crt.2 uc008crt.3 Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (PubMed:30383886, PubMed:36417862, PubMed:34871179). Essential for both the radial spoke head assembly and the central pair microtubule stability in ependymal motile cilia (PubMed:30383886). Required for motility of olfactory and neural cilia and for the structural integrity of ciliary axonemes in both 9+0 and 9+2 motile cilia (By similarity). Component of the axonemal radial spoke 1 (RS1) and 2 (RS2) complexes, at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the RS1 complex-specific anchor protein IQUB (PubMed:36417862, PubMed:34871179). Interacts with IQUB (PubMed:36417862). Interacts with RSPH3B (PubMed:34871179). Interacts with RSPH4A (PubMed:34871179). Interacts with RSPH6A (PubMed:30185526, PubMed:34871179). Cytoplasm, cytoskeleton, cilium axoneme toplasm, cytoskeleton, flagellum axoneme Cell projection, kinocilium Expressed in the testis, trachea, lung, oviduct and ependymal cells (at protein level). Expressed in the embryonic node at 7.5 dpc and in the nasal, lung, tracheal and brain ventricle epithelium at 18.5-19.5 dpc. RNAi-mediated depletion in the ependymal cilia results in a near complete central pair apparatus loss and alters the ciliary beat pattern from planar to rotational (PubMed:30383886). Multiple radial spokes proteins, including those in the head, are markedly down-regulated in the cilia (PubMed:30383886). Belongs to the flagellar radial spoke RSP9 family. radial spoke cilium movement molecular_function cytoplasm cytoskeleton cilium axoneme motile cilium axoneme assembly cell projection motile cilium assembly cilium assembly cilium movement involved in cell motility 9+2 motile cilium uc008crt.1 uc008crt.2 uc008crt.3 
ENSMUST00000024763.10 Mrps18a ENSMUST00000024763.10 mitochondrial ribosomal protein S18A (from RefSeq NM_026768.3) ENSMUST00000024763.1 ENSMUST00000024763.2 ENSMUST00000024763.3 ENSMUST00000024763.4 ENSMUST00000024763.5 ENSMUST00000024763.6 ENSMUST00000024763.7 ENSMUST00000024763.8 ENSMUST00000024763.9 Mrps18a NM_026768 Q5U5I3 Q5U5I3_MOUSE uc008crs.1 uc008crs.2 uc008crs.3 Mitochondrion structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit mitochondrial small ribosomal subunit ribosome translation uc008crs.1 uc008crs.2 uc008crs.3 
ENSMUST00000024764.12 Crip3 ENSMUST00000024764.12 cysteine-rich protein 3, transcript variant TLP-A (from RefSeq NM_181664.2) A0A8Q0P6Q3 A0A8Q0P6Q3_MOUSE Crip3 ENSMUST00000024764.1 ENSMUST00000024764.10 ENSMUST00000024764.11 ENSMUST00000024764.2 ENSMUST00000024764.3 ENSMUST00000024764.4 ENSMUST00000024764.5 ENSMUST00000024764.6 ENSMUST00000024764.7 ENSMUST00000024764.8 ENSMUST00000024764.9 NM_181664 uc008csv.1 uc008csv.2 uc008csv.1 uc008csv.2 
ENSMUST00000024773.6 Prph2 ENSMUST00000024773.6 peripherin 2 (from RefSeq NM_008938.2) ENSMUST00000024773.1 ENSMUST00000024773.2 ENSMUST00000024773.3 ENSMUST00000024773.4 ENSMUST00000024773.5 NM_008938 Prph2 Q3UWK3 Q3UWK3_MOUSE Rds uc008cuo.1 uc008cuo.2 uc008cuo.3 Membrane ; Multi- pass membrane protein Belongs to the PRPH2/ROM1 family. visual perception membrane integral component of membrane uc008cuo.1 uc008cuo.2 uc008cuo.3 
ENSMUST00000024774.14 Guca1b ENSMUST00000024774.14 guanylate cyclase activator 1B (from RefSeq NM_146079.1) ENSMUST00000024774.1 ENSMUST00000024774.10 ENSMUST00000024774.11 ENSMUST00000024774.12 ENSMUST00000024774.13 ENSMUST00000024774.2 ENSMUST00000024774.3 ENSMUST00000024774.4 ENSMUST00000024774.5 ENSMUST00000024774.6 ENSMUST00000024774.7 ENSMUST00000024774.8 ENSMUST00000024774.9 GUC1B_MOUSE NM_146079 Q8VBV8 uc008cvb.1 uc008cvb.2 Stimulates two retinal guanylyl cyclase (GCs) GUCY2E and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2E and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (PubMed:25673692). Cell membrane ; Lipid-anchor Photoreceptor inner segment Cell projection, cilium, photoreceptor outer segment te=Subcellular location is not affected by light or dark conditions. Expressed in rod photoreceptors in the retina (at protein level). Expressed in cone photoreceptor cells (PubMed:9620085). The N-terminus is blocked. Guca1a and Guca1b double knockout mice show an increase in response to light in dark-adapted cone photoreceptors (PubMed:25673692). Dark-adapted cone photoreceptors show a delayed response time and a delayed recovery time in response to light (PubMed:25673692). Guca1a, Guca1b and Rcvrn triple knockout mice show rod photoreceptors have a reduced current decay during light response (PubMed:29435986). Binds three calcium ions. photoreceptor outer segment photoreceptor inner segment calcium ion binding plasma membrane visual perception phototransduction calcium sensitive guanylate cyclase activator activity membrane guanylate cyclase regulator activity regulation of guanylate cyclase activity positive regulation of guanylate cyclase activity metal ion binding response to stimulus uc008cvb.1 uc008cvb.2 
ENSMUST00000024778.3 Med20 ENSMUST00000024778.3 mediator complex subunit 20, transcript variant 1 (from RefSeq NM_020048.4) ENSMUST00000024778.1 ENSMUST00000024778.2 MED20_MOUSE NM_020048 Q3UJQ7 Q3V418 Q6PAR6 Q9R0X0 Trfp uc008cvs.1 uc008cvs.2 uc008cvs.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Interacts with PPARG. Q9R0X0; Q9CQI9: Med30; NbExp=2; IntAct=EBI-398698, EBI-309220; Q9R0X0; Q9D7W5: Med8; NbExp=2; IntAct=EBI-398698, EBI-7990252; Q9R0X0; Q9BUE0: MED18; Xeno; NbExp=6; IntAct=EBI-398698, EBI-394640; Q9R0X0; Q6P2C8: MED27; Xeno; NbExp=2; IntAct=EBI-398698, EBI-394603; Q9R0X0; Q9NX70: MED29; Xeno; NbExp=2; IntAct=EBI-398698, EBI-394656; Q9R0X0; O75586: MED6; Xeno; NbExp=2; IntAct=EBI-398698, EBI-394624; Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9R0X0-1; Sequence=Displayed; Name=2; IsoId=Q9R0X0-2; Sequence=VSP_028989, VSP_028990; Name=3; IsoId=Q9R0X0-3; Sequence=VSP_028987, VSP_028988; Belongs to the Mediator complex subunit 20 family. ubiquitin ligase complex transcription cofactor activity transcription coactivator activity protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter protein ubiquitination mediator complex skeletal muscle cell differentiation ubiquitin protein ligase activity positive regulation of nucleic acid-templated transcription uc008cvs.1 uc008cvs.2 uc008cvs.3 
ENSMUST00000024779.15 Usp49 ENSMUST00000024779.15 ubiquitin specific peptidase 49 (from RefSeq NM_198421.2) ENSMUST00000024779.1 ENSMUST00000024779.10 ENSMUST00000024779.11 ENSMUST00000024779.12 ENSMUST00000024779.13 ENSMUST00000024779.14 ENSMUST00000024779.2 ENSMUST00000024779.3 ENSMUST00000024779.4 ENSMUST00000024779.5 ENSMUST00000024779.6 ENSMUST00000024779.7 ENSMUST00000024779.8 ENSMUST00000024779.9 NM_198421 Q6P9L4 UBP49_MOUSE uc008cvv.1 uc008cvv.2 uc008cvv.3 Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Component of a complex with RUVBL1 and PSMC5. Nucleus Belongs to the peptidase C19 family. mRNA splicing, via spliceosome cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus chromatin organization mRNA processing proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity zinc ion binding RNA splicing protein deubiquitination hydrolase activity histone H2B conserved C-terminal lysine deubiquitination thiol-dependent ubiquitinyl hydrolase activity histone binding metal ion binding uc008cvv.1 uc008cvv.2 uc008cvv.3 
ENSMUST00000024782.12 Pgc ENSMUST00000024782.12 progastricsin (pepsinogen C) (from RefSeq NM_025973.3) ENSMUST00000024782.1 ENSMUST00000024782.10 ENSMUST00000024782.11 ENSMUST00000024782.2 ENSMUST00000024782.3 ENSMUST00000024782.4 ENSMUST00000024782.5 ENSMUST00000024782.6 ENSMUST00000024782.7 ENSMUST00000024782.8 ENSMUST00000024782.9 NM_025973 PEPC_MOUSE Q9D7R7 Q9D7T2 Upg1 uc008cwb.1 uc008cwb.2 uc008cwb.3 Hydrolyzes a variety of proteins. Reaction=More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.; EC=3.4.23.3; Secreted. Belongs to the peptidase A1 family. Sequence=BAB25952.1; Type=Frameshift; Evidence=; positive regulation of antibacterial peptide production aspartic-type endopeptidase activity extracellular region extracellular space proteolysis digestion peptidase activity hydrolase activity protein catabolic process uc008cwb.1 uc008cwb.2 uc008cwb.3 
ENSMUST00000024783.9 Bysl ENSMUST00000024783.9 bystin-like (from RefSeq NM_016859.3) BYST_MOUSE ENSMUST00000024783.1 ENSMUST00000024783.2 ENSMUST00000024783.3 ENSMUST00000024783.4 ENSMUST00000024783.5 ENSMUST00000024783.6 ENSMUST00000024783.7 ENSMUST00000024783.8 NM_016859 O54825 Q3THF4 Q3UPY9 Q8VD68 uc008cvq.1 uc008cvq.2 uc008cvq.3 Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. Binds trophinin, tastin and cytokeratins. Cytoplasm Nucleus, nucleolus Note=Associated with 40S ribosomal subunits. High levels in preimplantation embryos, bone marrow, brain, testis and ovary. High levels of maternal transcript in unfertilized eggs. High levels up to blastocyst stage. Mice show embryonic lethality around stage 6.5 dpc shortly after implantation. Mice lacking maternal Bysl transcript upon injection of siRNA into fertilized eggs are arrested at the 16- cell stage, fail to induce trophectoderm, and show altered morphology of developing nucleoli. Embryonic stem cells lacking Bysl show accumulation of pre-20S rRNA precursors and a reduction of 40S ribosomal subunits in the cytoplasm. Belongs to the bystin family. Sequence=AAH17530.3; Type=Erroneous initiation; Evidence=; Sequence=BAB31619.2; Type=Erroneous initiation; Evidence=; Sequence=BAC38736.1; Type=Erroneous initiation; Evidence=; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) in utero embryonic development blastocyst formation trophectodermal cell differentiation nucleus nucleolus cytoplasm cytoplasmic microtubule rRNA processing cell proliferation snoRNA binding preribosome, small subunit precursor ribosome biogenesis cell projection intracellular membrane-bounded organelle apical part of cell perinuclear region of cytoplasm uc008cvq.1 uc008cvq.2 uc008cvq.3 
ENSMUST00000024791.15 Trem2 ENSMUST00000024791.15 triggering receptor expressed on myeloid cells 2, transcript variant 1 (from RefSeq NM_031254.3) ENSMUST00000024791.1 ENSMUST00000024791.10 ENSMUST00000024791.11 ENSMUST00000024791.12 ENSMUST00000024791.13 ENSMUST00000024791.14 ENSMUST00000024791.2 ENSMUST00000024791.3 ENSMUST00000024791.4 ENSMUST00000024791.5 ENSMUST00000024791.6 ENSMUST00000024791.7 ENSMUST00000024791.8 ENSMUST00000024791.9 NM_031254 Q8CGK4 Q8CIA6 Q99NH8 Q99NH9 Q9JL34 TREM2_MOUSE Trem2a Trem2b Trem2c uc008cxj.1 uc008cxj.2 uc008cxj.3 uc008cxj.4 The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:11241283). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia (PubMed:27477018, PubMed:29518356). Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro- inflammatory cytokines, such as IL6R and CCL3, and the anti- inflammatory cytokine ARG1 (PubMed:27477018, PubMed:29518356). Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia (PubMed:27477018). Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin (By similarity). Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade (PubMed:28077724). Required for microglial phagocytosis of apoptotic neurons (PubMed:24990881). Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain (PubMed:15728241, PubMed:28592261, PubMed:29752066, PubMed:25631124). Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide (PubMed:30232263, PubMed:29663649, PubMed:28483841, PubMed:29859094). It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro- inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB (PubMed:29663649). During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling (PubMed:28592261). Plays a role in microglial MTOR activation and metabolism (PubMed:28802038). Regulates age-related changes in microglial numbers (PubMed:30548312, PubMed:29752066, PubMed:25631124). Triggers activation of the immune responses in macrophages and dendritic cells (By similarity). Mediates cytokine- induced formation of multinucleated giant cells which are formed by the fusion of macrophages (PubMed:18957693). In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity). Involved in the positive regulation of osteoclast differentiation (PubMed:16418779). Monomer (By similarity). After ectodomain shedding, the extracellular domain oligomerizes, which is enhanced and stabilized by binding of phosphatidylserine (By similarity). Interacts with TYROBP/DAP12 (PubMed:11241283, PubMed:29518356). Interaction with TYROBP is required for stabilization of the TREM2 C-terminal fragment (TREM2-CTF) which is produced by proteolytic processing (By similarity). Q99NH8; P70206: Plxna1; NbExp=4; IntAct=EBI-15982016, EBI-771260; Q99NH8; PRO_0000000092 [P05067]: APP; Xeno; NbExp=2; IntAct=EBI-15982016, EBI-821758; [Isoform 1]: Cell membrane ; Single-pass type I membrane protein [Isoform 2]: Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99NH8-1; Sequence=Displayed; Name=2; Synonyms=svTREM-2b; IsoId=Q99NH8-2; Sequence=VSP_010794; Expressed in the brain, specifically in microglia (at protein level) (PubMed:15728241, PubMed:28802038, PubMed:28855301, PubMed:28077724, PubMed:28592261, PubMed:29794134, PubMed:29752066, PubMed:27477018, PubMed:28559417). Expressed in macrophages (at protein level) (PubMed:11241283, PubMed:28802038, PubMed:28559417). Expressed at higher levels in the CNS, heart and lung than in lymph nodes or in other non-lymphoid tissues such as kidney, liver and testis (PubMed:12472885). In the CNS not all microglia express TREM2 (PubMed:12472885). Brain regions with an incomplete blood-brain barrier had the lowest percentages of TREM2 expressing microglia, whereas the lateral entorhinal and cingulate cortex had the highest percentages (PubMed:12472885). Expression is increased during oxygen-glucose deprivation, reaching the highest expression level 12 hours after reoxygenation. Expression is also increased by ischemia, where maximum expression is reached 7 days after ischemic conditions. Undergoes ectodomain shedding through proteolytic cleavage by ADAM10 and ADAM17 to produce a transmembrane segment, the TREM2 C- terminal fragment (TREM2-CTF), which is subsequently cleaved by gamma- secretase. Mice exhibit a strong increase in self-grooming behavior, defective social behavior, and some sensorimotor defects (PubMed:25631124, PubMed:29752066). Aged mice show decreases in age- related neuronal loss and increases in synaptic density in the substantia nigra and the hippocampus (PubMed:30548312). They also exhibit a decrease in the connectivity between the retrosplenial cortices, subiculum, hippocampus and anterior cingulate, as a result of defective synaptic growth thus impairing their function (PubMed:29752066). Sequence=AAF69825.1; Type=Frameshift; Evidence=; lipopolysaccharide binding beta-amyloid binding microglial cell activation positive regulation of protein phosphorylation microglial cell activation involved in immune response positive regulation of antigen processing and presentation of peptide antigen via MHC class II response to ischemia transmembrane signaling receptor activity protein binding phospholipid binding extracellular region plasma membrane integral component of plasma membrane phagocytosis, engulfment high-density lipoprotein particle binding lipid binding regulation of gene expression negative regulation of autophagy positive regulation of gene expression positive regulation of mitochondrion organization membrane integral component of membrane low-density lipoprotein particle binding osteoclast differentiation intrinsic component of plasma membrane lipopolysaccharide-mediated signaling pathway regulation of TOR signaling positive regulation of TOR signaling detection of lipopolysaccharide detection of peptidoglycan regulation of interleukin-6 production negative regulation of interleukin-1 beta production negative regulation of tumor necrosis factor production positive regulation of interleukin-10 production apolipoprotein binding apolipoprotein A-I binding very-low-density lipoprotein particle binding positive regulation of macrophage fusion signaling receptor activity defense response to bacterium peptidoglycan binding negative regulation of apoptotic process apoptotic cell clearance macromolecular complex binding innate immune response regulation of innate immune response positive regulation of osteoclast differentiation astrocyte activation positive regulation of protein secretion regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of calcium-mediated signaling positive regulation of chemotaxis regulation of resting membrane potential positive regulation of phagocytosis, engulfment microglial cell proliferation positive regulation of ERK1 and ERK2 cascade detection of lipoteichoic acid lipoteichoic acid binding cellular response to lipoteichoic acid cellular response to peptidoglycan regulation of macrophage inflammatory protein 1 alpha production lipoprotein particle binding dendritic cell differentiation scaffold protein binding beta-amyloid clearance import into cell positive regulation of beta-amyloid clearance positive regulation of engulfment of apoptotic cell positive regulation of NIK/NF-kappaB signaling positive regulation of proteasomal protein catabolic process positive regulation of inward rectifier potassium channel activity regulation of intracellular signal transduction positive regulation of protein localization to plasma membrane positive regulation of C-C chemokine receptor CCR7 signaling pathway positive regulation of microglial cell activation negative regulation of autophagic cell death positive regulation of microglial cell migration cellular response to beta-amyloid positive regulation of CAMKK-AMPK signaling cascade protein tyrosine kinase binding positive regulation of CD40 signaling pathway positive regulation of ATP biosynthetic process uc008cxj.1 uc008cxj.2 uc008cxj.3 uc008cxj.4 
ENSMUST00000024794.12 Tspo2 ENSMUST00000024794.12 translocator protein 2 (from RefSeq NM_027292.2) Bzrpl1 ENSMUST00000024794.1 ENSMUST00000024794.10 ENSMUST00000024794.11 ENSMUST00000024794.2 ENSMUST00000024794.3 ENSMUST00000024794.4 ENSMUST00000024794.5 ENSMUST00000024794.6 ENSMUST00000024794.7 ENSMUST00000024794.8 ENSMUST00000024794.9 NM_027292 Q9CRZ8 TSPO2_MOUSE uc008cxy.1 uc008cxy.2 uc008cxy.3 Cholesterol-binding protein involved in the redistribution of cholesterol from lipid droplets to the endoplasmic reticulum (PubMed:19729679, PubMed:32358067). Required to meet cholesterol demands during erythropoietic differentiation (PubMed:19729679, PubMed:32358067). May play a role in transport processes at the plasma membrane of erythrocytes, including regulating VDAC-mediated ATP export, and import of the heme precursors protoporphyrin IX and 5- aminolevulinic acid (By similarity). Homotetramer. May also form homodimer. Endoplasmic reticulum membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein. Note=Localizes to the plasma membrane and intracellular membranes in developing and mature erythrocytes. Expressed in liver, bone marrow and spleen. In spleen, detected in red pulp but not in white pulp. Not expressed at 10.5 dpc. First detected at 12.5 dpc in the primordial liver (PubMed:19729679). Increased hepatic levels are found at 15.5 dpc followed by decline throughout newborn stage P1 and postnatal stages P5 and P10 with no hepatic expression in the adult (PubMed:19729679). In bone marrow, expressed during late gestation stages and remains elevated until adulthood (PubMed:19729679). In newborn and adult mice, also expressed in spleen (PubMed:19729679). The C-terminal region mediates cholesterol-binding. Decreases erythrocyte count and increases reticulocyte count (PubMed:32358067). Abnormal erythroblast cytokinesis and differentiation (PubMed:32358067). Decreases hemoglobin levels in maturing erythroid cells (PubMed:32358067). Belongs to the TspO/BZRP family. endoplasmic reticulum endoplasmic reticulum membrane biological_process cholesterol binding membrane integral component of membrane uc008cxy.1 uc008cxy.2 uc008cxy.3 
ENSMUST00000024802.10 Ppil1 ENSMUST00000024802.10 peptidylprolyl isomerase (cyclophilin)-like 1 (from RefSeq NM_026845.4) ENSMUST00000024802.1 ENSMUST00000024802.2 ENSMUST00000024802.3 ENSMUST00000024802.4 ENSMUST00000024802.5 ENSMUST00000024802.6 ENSMUST00000024802.7 ENSMUST00000024802.8 ENSMUST00000024802.9 NM_026845 PPIL1_MOUSE Q3UA03 Q9D0W5 uc008bsm.1 uc008bsm.2 uc008bsm.3 Involved in pre-mRNA splicing as component of the spliceosome (PubMed:33220177). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Catalyzes prolyl peptide bond isomerization in CDC40/PRP17 (By similarity). Plays an important role in embryonic brain development; this function is independent of its isomerase activity (PubMed:33220177). Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Inhibited by Cyclosporin A. Identified in the spliceosome C complex. Interacts with SNW1/SKIP. Interacts with CDC40/PRP17; this interaction leads to CDC40 isomerization. Interacts with RBM22. Nucleus Widely expressed in the developing cortex at 14.5 dpc. Mutant mice, in which PPIL1 is truncated at position 102, die before 12.5 dpc. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. mRNA splicing, via spliceosome protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity nucleus spliceosomal complex mRNA processing protein folding RNA splicing cyclosporin A binding isomerase activity U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome disordered domain specific binding uc008bsm.1 uc008bsm.2 uc008bsm.3 
ENSMUST00000024805.15 Cpne5 ENSMUST00000024805.15 copine V, transcript variant 2 (from RefSeq NM_153166.2) CPNE5_MOUSE Cpne5 ENSMUST00000024805.1 ENSMUST00000024805.10 ENSMUST00000024805.11 ENSMUST00000024805.12 ENSMUST00000024805.13 ENSMUST00000024805.14 ENSMUST00000024805.2 ENSMUST00000024805.3 ENSMUST00000024805.4 ENSMUST00000024805.5 ENSMUST00000024805.6 ENSMUST00000024805.7 ENSMUST00000024805.8 ENSMUST00000024805.9 NM_153166 Q8JZW4 uc008bsk.1 uc008bsk.2 uc008bsk.3 uc008bsk.4 Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]. Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Plays a role in dendrite formation by melanocytes. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per C2 domain. Perikaryon Cell projection Expressed in the cerebra and cerebellum of newborn brain. Expressed in the eye, lung and muscles but weakly expressed in the adult brain (at protein level) (PubMed:18614158). Expressed at the ventricular zone and subventricular zone areas, in the tectum, frontal cortex, ganglionic eminence, dorsal thalamus, hippocampus and tegmentum of the embryonic brain from 12.5 to 14.5 dpc. Expressed in neural progenitor cells (at protein level). Expressed in the embryonic brain from 10.5 to 17.5 dpc. Expressed in the telencephalon, mesencephalon and rhombencephalon areas from 11.5 to 12.5 dpc. Expressed in the developing central nervous system (CNS), such as the frontal cortex, hypothalamus and ventricular zones along the IV ventricle and aquaeductus mesencephali at 13.5 dpc (PubMed:18614158). Belongs to the copine family. calcium-dependent phospholipid binding plasma membrane cell differentiation cell projection neuron projection neuronal cell body perikaryon cellular response to calcium ion positive regulation of dendrite extension uc008bsk.1 uc008bsk.2 uc008bsk.3 uc008bsk.4 
ENSMUST00000024810.8 Fgd2 ENSMUST00000024810.8 FYVE, RhoGEF and PH domain containing 2, transcript variant 4 (from RefSeq NR_189096.1) ENSMUST00000024810.1 ENSMUST00000024810.2 ENSMUST00000024810.3 ENSMUST00000024810.4 ENSMUST00000024810.5 ENSMUST00000024810.6 ENSMUST00000024810.7 FGD2_MOUSE NR_189096 O88841 Q2L9D2 Q3U195 Q7TSE3 Q8BY35 Q8VDH4 uc008bsx.1 uc008bsx.2 uc008bsx.3 uc008bsx.4 Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Cytoplasm Nucleus Early endosome Early endosome membrane Cell projection, ruffle membrane Cytoplasm, cytoskeleton Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. Lymph node, spleen, B-lymphocytes and macrophages (at protein level). Expressed at high levels in lymph node, spleen, B- lymphocytes and bone marrow macrophages. Expressed at lower levels in mature bone marrow dendritic cells. In both immature and mature B- cells, expression is down-regulated by prior B-cell receptor signaling. Expression remains high in resting B and memory cells but declines upon differentiation into plasma cells. The FYVE-type zinc-finger is necessary for early endosome localization. Recruitment to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides. The PH domain is necessary for localization to the ruffle membrane. Recruitment to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein. The DH domain is necessary for its ability to activate JNK1 via CDC42. Sequence=AAC35430.1; Type=Frameshift; Evidence=; Sequence=AAH21845.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=AAP45200.1; Type=Erroneous gene model prediction; Evidence=; ruffle guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity nucleus cytoplasm endosome early endosome cytoskeleton plasma membrane membrane early endosome membrane ruffle membrane regulation of Rho protein signal transduction cell projection positive regulation of JUN kinase activity metal ion binding phosphatidylinositol phosphate binding uc008bsx.1 uc008bsx.2 uc008bsx.3 uc008bsx.4 
ENSMUST00000024811.9 Pim1 ENSMUST00000024811.9 proviral integration site 1, transcript variant 1 (from RefSeq NM_008842.4) ENSMUST00000024811.1 ENSMUST00000024811.2 ENSMUST00000024811.3 ENSMUST00000024811.4 ENSMUST00000024811.5 ENSMUST00000024811.6 ENSMUST00000024811.7 ENSMUST00000024811.8 F6XDQ5 NM_008842 P06803 PIM1_MOUSE Pim-1 Q8CFN8 uc008bsz.1 uc008bsz.2 uc008bsz.3 uc008bsz.4 Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis (PubMed:15199164, PubMed:1825810). Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3) (By similarity). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity (PubMed:18438430). The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis (PubMed:18438430). Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1 (PubMed:15280015). Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis (By similarity). Stimulates cell cycle progression at the G1- S and G2-M transitions by phosphorylation of CDC25A and CDC25C (By similarity). Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability (By similarity). Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels (By similarity). Phosphorylation of CDKN1B, induces 14-3-3 proteins binding, nuclear export and proteasome- dependent degradation (By similarity). May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3 (By similarity). Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis (PubMed:19687226). Acts as a positive regulator of mTORC1 signaling by mediating phosphorylation and inhibition of DEPDC5 component of the GATOR1 complex (PubMed:31548394). Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells (By similarity). Promotes brown adipocyte differentiation (PubMed:27923061). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with RP9 (PubMed:10931201). Interacts with HSP90AA1, this interaction stabilizes PIM1 protein levels. Interacts (ubiquitinated form) with HSP70 and promotes its proteasomal degradation (By similarity). [Isoform 1]: Isoform 1 is isolated as a monomer whereas isoform 2 complexes with other proteins. Cytoplasm Nucleus Cell membrane Note=Mainly located in the cytoplasm. Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=P06803-1; Sequence=Displayed; Name=2; IsoId=P06803-2; Sequence=VSP_059830; Autophosphorylated on both serine/threonine and tyrosine residues. Phosphorylated. Interaction with PPP2CA promotes dephosphorylation (By similarity). Ubiquitinated, leading to proteasomal degradation. Note=Frequently activated by provirus insertion in murine leukemia virus-induced T-cell lymphomas. Deficient mice are viable and fertile however they have a specific defect in interleukin-7 (IL7)-driven growth of pre-B cells, as well as IL3-dependent growth of bone marrow-derived mast cells. Triple knockout mice PIM1/PIM2/PIM3 are viable and fertile too, but their body size is reduced at birth and throughout postnatal life due to a reduction in the number of cells rather than cell size. [Isoform 2]: Initiates from CTG codon. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleolus cytoplasm cytosol plasma membrane protein phosphorylation apoptotic process cell cycle transcription factor binding cell proliferation membrane kinase activity phosphorylation transferase activity manganese ion binding hyaluronan metabolic process ribosomal small subunit binding negative regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription, DNA-templated protein autophosphorylation metal ion binding protein stabilization positive regulation of cardiac muscle cell proliferation vitamin D receptor signaling pathway regulation of hematopoietic stem cell proliferation positive regulation of cardioblast proliferation uc008bsz.1 uc008bsz.2 uc008bsz.3 uc008bsz.4 
ENSMUST00000024816.13 Cmtr1 ENSMUST00000024816.13 cap methyltransferase 1 (from RefSeq NM_028791.6) CMTR1_MOUSE ENSMUST00000024816.1 ENSMUST00000024816.10 ENSMUST00000024816.11 ENSMUST00000024816.12 ENSMUST00000024816.2 ENSMUST00000024816.3 ENSMUST00000024816.4 ENSMUST00000024816.5 ENSMUST00000024816.6 ENSMUST00000024816.7 ENSMUST00000024816.8 ENSMUST00000024816.9 Ftsjd2 Kiaa0082 NM_028791 Q3U3G5 Q3U7Y9 Q6A0D5 Q8C7V0 Q9DBC3 uc008bth.1 uc008bth.2 uc008bth.3 S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG- capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S- adenosyl-L-homocysteine; Xref=Rhea:RHEA:67020, Rhea:RHEA-COMP:17167, Rhea:RHEA-COMP:17168, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, ChEBI:CHEBI:167609; EC=2.1.1.57; Evidence=; Interacts with POLR2A (via C-terminus). Nucleus Sequence=BAD32161.1; Type=Frameshift; Evidence=; nucleic acid binding mRNA (nucleoside-2'-O-)-methyltransferase activity nucleus nucleoplasm cytoplasm cytosol 7-methylguanosine mRNA capping mRNA processing methyltransferase activity transferase activity methylation mRNA methylation cap1 mRNA methylation uc008bth.1 uc008bth.2 uc008bth.3 
ENSMUST00000024817.15 Rnf8 ENSMUST00000024817.15 ring finger protein 8 (from RefSeq NM_021419.2) ENSMUST00000024817.1 ENSMUST00000024817.10 ENSMUST00000024817.11 ENSMUST00000024817.12 ENSMUST00000024817.13 ENSMUST00000024817.14 ENSMUST00000024817.2 ENSMUST00000024817.3 ENSMUST00000024817.4 ENSMUST00000024817.5 ENSMUST00000024817.6 ENSMUST00000024817.7 ENSMUST00000024817.8 ENSMUST00000024817.9 NM_021419 Q4FJV7 Q8VC56 Q9JK13 RNF8_MOUSE Rnf8 uc008btf.1 uc008btf.2 uc008btf.3 uc008btf.4 E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non- histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'- linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'- linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis (PubMed:20153262, PubMed:28552346). At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with ATM- phosphorylated MDC1. Interacts (via FHA domain) with 'Thr-4829' phosphorylated HERC2 (via C-terminus) (By similarity). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm (PubMed:28552346). Interacts with WRAP53/TCAB1 (By similarity). (Microbial infection) May interact with the L.monocytogenes protein actA; however, given these errors in the sequence (AJ242721), the relevance of the interaction with actA remains to be confirmed. Q8VC56; Q96AP0: ACD; Xeno; NbExp=2; IntAct=EBI-15954293, EBI-717666; Nucleus toplasm dbody Chromosome, telomere te=Recruited at uncapped telomeres (PubMed:21857671, PubMed:22101936). Following DNA double-strand breaks, recruited to the sites of damage. During prophase, concomitant with nuclear envelope breakdown, localizes throughout the cell, with a dotted pattern. In telophase, again in the nucleus and also with a discrete dotted pattern in the cytoplasm. In late telophase and during cytokinesis, localizes in the midbody of the tubulin bridge joining the daughter cells. Does not seem to be associated with condensed chromosomes at any time during the cell cycle (By similarity). During spermatogenesis, sequestered in the cytoplasm by PIWIL1: RNF8 is released following ubiquitination and degradation of PIWIL1 (PubMed:28552346). The FHA domain specifically recognizes and binds ATM- phosphorylated MDC1 and phosphorylated HERC2 (By similarity). This domain is also required for proper recruitment to DNA damage sites after UV irradiation, ionizing radiation, or treatment with an alkylating agent (By similarity). Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger. Male mice are infertile, while females do not show defects. Male mice display defects in histone H2A and H2B ubiquitination in testis cells. While meiotic sex chromosome inactivation in the XY body prior to meiosis is not affected, H4K16ac is decreased, leading to defects in the replacement of histones by protamines during spermiogenesis. Mice lacking both Rnf8 and Chfr develop thymic lymphomas and chromosomes are frequently altered, due to defects in DNA damage response and defects in damage-induced activation of ATM kinase. Belongs to the RNF8 family. The precise role of Rnf8 at telomeres is subject to debate. 2 publications reported recruitment of Rnf8 at uncapped telomeres followed by regulation of non-homologous end joining (NHEJ), however the 2 publications reported different data and conclusions. According to a report, Rnf8 promotes telomere end protection and inhibits NHEJ by mediating ubiquitination via 'Lys-63'-linked ubiquitin and stabilization of Tpp1 at uncapped telomeres (PubMed:22101936). According to another report, Rnf8 recruitment at uncapped telomeres leads to promote NHEJ and the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that Rnf8 may have a detrimental role in case of telomeric crisis and enhance cancer development by aggravating telomere-induced genome instability (PubMed:21857671). According to a well-established model, RNF8 initiate H2A 'Lys- 63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non- histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidence is however required to confirm these data. Sequence=CAB92239.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAB92239.1; Type=Frameshift; Evidence=; ubiquitin ligase complex chromosome, telomeric region chromatin binding ubiquitin-protein transferase activity protein binding nucleus chromosome cytoplasm cytosol DNA repair double-strand break repair double-strand break repair via nonhomologous end joining chromatin organization ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus cell cycle spermatid development zinc ion binding response to ionizing radiation protein ubiquitination transferase activity midbody ubiquitin protein ligase binding histone H2A ubiquitination histone H2B ubiquitination negative regulation of transcription elongation from RNA polymerase II promoter spermatogenesis, exchange of chromosomal proteins site of double-strand break histone binding identical protein binding protein homodimerization activity ubiquitin binding histone exchange isotype switching positive regulation of DNA repair metal ion binding cell division protein autoubiquitination ubiquitin protein ligase activity protein K63-linked ubiquitination histone H2A K63-linked ubiquitination protein K48-linked ubiquitination uc008btf.1 uc008btf.2 uc008btf.3 uc008btf.4 
ENSMUST00000024826.8 Tff2 ENSMUST00000024826.8 trefoil factor 2 (spasmolytic protein 1) (from RefSeq NM_009363.3) ENSMUST00000024826.1 ENSMUST00000024826.2 ENSMUST00000024826.3 ENSMUST00000024826.4 ENSMUST00000024826.5 ENSMUST00000024826.6 ENSMUST00000024826.7 NM_009363 Q9QX97 Q9QX97_MOUSE TFF2/SP Tff2 uc008bul.1 uc008bul.2 uc008bul.3 Lacks conserved residue(s) required for the propagation of feature annotation. uc008bul.1 uc008bul.2 uc008bul.3 
ENSMUST00000024827.5 Tff3 ENSMUST00000024827.5 trefoil factor 3, intestinal (from RefSeq NM_011575.2) ENSMUST00000024827.1 ENSMUST00000024827.2 ENSMUST00000024827.3 ENSMUST00000024827.4 Itf NM_011575 Q62395 Q64352 TFF3_MOUSE uc008buk.1 uc008buk.2 uc008buk.3 uc008buk.4 Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). Monomer. Homodimer; disulfide-linked. Secreted, extracellular space, extracellular matrix Cytoplasm Expressed in goblet cells of the intestines and colon (at protein level). Expressed abundantly in goblet cells of intestine and colon, and at low levels in stomach. No expression in brain, lung, spleen, kidney, uterus, pancreas, liver, heart or thymus. No expression found in embryos. Mice lacking this gene show impaired mucosal healing after injury and die from extensive colitis after oral administration of dextran sulfate. extracellular region extracellular space cytoplasm regulation of glucose metabolic process secretory granule maintenance of gastrointestinal epithelium uc008buk.1 uc008buk.2 uc008buk.3 uc008buk.4 
ENSMUST00000024829.8 Abcg1 ENSMUST00000024829.8 ATP binding cassette subfamily G member 1 (from RefSeq NM_009593.2) ABCG1_MOUSE Abc8 Abcg1 ENSMUST00000024829.1 ENSMUST00000024829.2 ENSMUST00000024829.3 ENSMUST00000024829.4 ENSMUST00000024829.5 ENSMUST00000024829.6 ENSMUST00000024829.7 NM_009593 Q64343 Wht1 uc008buj.1 uc008buj.2 uc008buj.3 uc008buj.4 uc008buj.5 uc008buj.6 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The human protein is involved in macrophage cholesterol efflux and may regulate cellular lipid homeostasis in other cell types. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF323659.1, U34920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta- hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:14668945). The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (By similarity). Reaction=7beta-hydroxycholesterol(in) + ATP + H2O = 7beta- hydroxycholesterol(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:39795, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:42989, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Reaction=ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate; Xref=Rhea:RHEA:39051, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Reaction=an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O = ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate; Xref=Rhea:RHEA:46468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:64583, ChEBI:CHEBI:456216; Evidence=; Reaction=a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38903, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; The cholesterol efflux is enhanced by APOA1. Homodimer; disulfide-linked. Homooligomer. May form heterodimers with several heterologous partners of the ABCG subfamily. Forms heterodimers with ABCG4. Interacts with CAV1; this interaction regulates ABCG1-mediated cholesterol efflux. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Cell membrane Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes. Expressed mainly in brain, thymus, lung, adrenals, spleen and placenta. Little or no expression in liver, kidney, heart, muscle or testes. Strongly induced in macrophage cell line RAW 264.7 during cholesterol influx. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Down-regulated by endotoxins or cytokines (TNF and IL1) in J-774 macrophages. Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. Golgi membrane nucleotide binding ATP binding phospholipid transporter activity mitochondrion endosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane lipid transport cholesterol metabolic process external side of plasma membrane response to organic substance negative regulation of macrophage derived foam cell differentiation regulation of cholesterol esterification positive regulation of cholesterol efflux negative regulation of lipid storage membrane integral component of membrane ATPase activity toxin transporter activity cholesterol transport intracellular cholesterol transport cholesterol efflux phospholipid efflux response to lipid sterol-transporting ATPase activity low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling glycoprotein transport ATPase activity, coupled to transmembrane movement of substances cholesterol homeostasis protein homodimerization activity amyloid precursor protein catabolic process ADP binding reverse cholesterol transport positive regulation of cholesterol biosynthetic process protein heterodimerization activity positive regulation of protein secretion recycling endosome transmembrane transport phospholipid homeostasis cellular response to high density lipoprotein particle stimulus toxin transport positive regulation of beta-amyloid formation uc008buj.1 uc008buj.2 uc008buj.3 uc008buj.4 uc008buj.5 uc008buj.6 
ENSMUST00000024831.8 Tff1 ENSMUST00000024831.8 trefoil factor 1 (from RefSeq NM_009362.2) ENSMUST00000024831.1 ENSMUST00000024831.2 ENSMUST00000024831.3 ENSMUST00000024831.4 ENSMUST00000024831.5 ENSMUST00000024831.6 ENSMUST00000024831.7 NM_009362 Q149Y8 Q149Y8_MOUSE Tff1 uc008buo.1 uc008buo.2 uc008buo.3 Secreted uc008buo.1 uc008buo.2 uc008buo.3 
ENSMUST00000024832.9 Rsph1 ENSMUST00000024832.9 radial spoke head 1 homolog (Chlamydomonas), transcript variant 1 (from RefSeq NM_025290.4) ENSMUST00000024832.1 ENSMUST00000024832.2 ENSMUST00000024832.3 ENSMUST00000024832.4 ENSMUST00000024832.5 ENSMUST00000024832.6 ENSMUST00000024832.7 ENSMUST00000024832.8 NM_025290 Q8VIG3 Q9DAL5 RSPH1_MOUSE Tsga2 uc008buu.1 uc008buu.2 uc008buu.3 uc008buu.4 Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. Component of the axonemal radial spoke 1 (RS1) and 2 (RS2) complexes, at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the RS1 complex-specific anchor protein IQUB (PubMed:36417862, PubMed:34871179). Interacts with RSPH3B (PubMed:34871179). Interacts with RSPH4A (PubMed:34871179). Interacts with RSPH6A (PubMed:30185526, PubMed:34871179). Cytoplasm Chromosome Cytoplasm, cytoskeleton, cilium axoneme toplasm, cytoskeleton, flagellum axoneme Note=Cytoplasmic in late spermatocytes, secondary spermatocytes and round spermatids. Gathered around metaphase chromosomes during meiotic divisions. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VIG3-1; Sequence=Displayed; Name=2; IsoId=Q8VIG3-2; Sequence=Not described; Expressed in the trachea, ependymal cells, oviduct and ependymal cells (at protein level) (PubMed:32203505, PubMed:34871179). Germ cell specific. Specifically expressed in testis, and to a lower extent in ovary. Not expressed in somatic tissues (PubMed:9578619). During male germ cell development it is not detected until 12 days. Significant expression is detected from 14-day- old through to adult testis. Expression is first detected in the pachytene spermatocytes at stage V, becomes stronger from the late pachytene spermatocytes to round spermatid stage, and then gradually decreases as the morphogenesis proceeds further. Not expressed in germ cells located in the first layer of the seminiferous epithelium (spermatogonia, leptotene and zygotene spermatocytes). Sequence=BAB83693.1; Type=Frameshift; Evidence=; condensed nuclear chromosome outer dense fiber molecular_function chromosome cytoplasm cilium spermatid development motile cilium axoneme assembly sperm flagellum cell projection meiotic cell cycle meiotic spindle uc008buu.1 uc008buu.2 uc008buu.3 uc008buu.4 
ENSMUST00000024839.6 Sik1 ENSMUST00000024839.6 salt inducible kinase 1 (from RefSeq NM_010831.3) ENSMUST00000024839.1 ENSMUST00000024839.2 ENSMUST00000024839.3 ENSMUST00000024839.4 ENSMUST00000024839.5 Msk NM_010831 Q3UR46 Q60670 SIK1_MOUSE Sik Snf1lk uc008bvr.1 uc008bvr.2 uc008bvr.3 Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium- sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down- regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light- induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation on Thr-182. Also activated by phosphorylation on Thr-322 in response to increases in intracellular sodium in parallel with elevations in intracellular calcium through the reversible sodium/calcium exchanger. Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ. Interacts with ATP1A1 (By similarity). Cytoplasm. Nucleus. Note=Following ACTH (adrenocorticotropic hormone) treatment and subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ. Expressed in lung, skin, ovary, heart and stomach. No expression in brain, liver or adult skeletal muscle but is present in skeletal muscle progenitor cells of the somite beginning at 9.5 dpc. Present at 8.0 dpc in the monolayer of presumptive myocardial cells but rapidly down-regulated at 8.5 dpc upon primitive ventricle formation, although still present in myocardial cells that will populate the primitive atrium and bulbus cordis. At 9.5 dpc expression is down- regulated in the primitive atrium but observed in the sinus venosus and truncus arteriosus. Expression is stimulated by CREB1 in myocytes; direct target of CREB1. The RK-rich region determines the subcellular location. Phosphorylated at Thr-182 by STK11/LKB1 in complex with STE20- related adapter-alpha (STRADA) pseudo kinase and CAB39, leading to its activation. Phosphorylation at Thr-182 promotes autophosphorylation at Ser-186, which is required for sustained activity. Autophosphorylation at Ser-186 is maintained by sequential phosphorylation at Thr-182 by GSK3-beta. GSK3-beta cannot initiate phosphorylation at Thr-182, it can only maintain it. Phosphorylation at Ser-577 by PKA promotes translocation to the cytoplasm. Phosphorylation at Thr-322 by CaMK1 following intracellular sodium concentration leads to activation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. negative regulation of transcription from RNA polymerase II promoter nucleotide binding magnesium ion binding regulation of sodium ion transport protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm cytosol protein phosphorylation cell cycle multicellular organism development regulation of mitotic cell cycle cAMP response element binding protein binding regulation of myotube differentiation negative regulation of triglyceride biosynthetic process kinase activity phosphorylation transferase activity protein kinase binding cell differentiation negative regulation of CREB transcription factor activity intracellular signal transduction histone deacetylase binding entrainment of circadian clock by photoperiod anoikis regulation of cell differentiation negative regulation of gluconeogenesis protein autophosphorylation metal ion binding rhythmic process cardiac muscle cell differentiation 14-3-3 protein binding uc008bvr.1 uc008bvr.2 uc008bvr.3 
ENSMUST00000024851.10 Ndc80 ENSMUST00000024851.10 NDC80 kinetochore complex component (from RefSeq NM_023294.2) ENSMUST00000024851.1 ENSMUST00000024851.2 ENSMUST00000024851.3 ENSMUST00000024851.4 ENSMUST00000024851.5 ENSMUST00000024851.6 ENSMUST00000024851.7 ENSMUST00000024851.8 ENSMUST00000024851.9 Hec1 Kntc2 NDC80_MOUSE NM_023294 Q3TQT6 Q3UWM5 Q99P70 Q9D0F1 uc008dmk.1 uc008dmk.2 uc008dmk.3 Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules. Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end. Interacts with NEK2 and ZWINT specifically during mitosis. Interacts with CENPH and MIS12. May interact with AURKB, PSMC2, PSMC5 and SMC1A. May interact with RB1 during G2 phase and mitosis. Interacts with CKAP5 (By similarity). Interacts with CDT1; leading to kinetochore localization of CDT1 (By similarity). Nucleus Chromosome, centromere, kinetochore Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. Expressed in spleen, testis and thymus. Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. Also phosphorylated by AURKA and AURKB. Acetylated at Lys-53 and Lys-59 by KAT5 during mitosis, promoting robust kinetochore-microtubule attachment. Deacetylated by SIRT1. Belongs to the NDC80/HEC1 family. mitotic sister chromatid segregation establishment of mitotic spindle orientation chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed nuclear chromosome kinetochore condensed nuclear chromosome outer kinetochore protein binding nucleus nucleoplasm chromosome centrosome cell cycle mitotic spindle organization chromosome segregation attachment of spindle microtubules to kinetochore Ndc80 complex identical protein binding cell division metaphase plate congression attachment of mitotic spindle microtubules to kinetochore kinetochore organization positive regulation of mitotic cell cycle spindle assembly checkpoint positive regulation of protein localization to kinetochore uc008dmk.1 uc008dmk.2 uc008dmk.3 
ENSMUST00000024854.9 Clip4 ENSMUST00000024854.9 CAP-GLY domain containing linker protein family, member 4, transcript variant 1 (from RefSeq NM_030179.3) CLIP4_MOUSE ENSMUST00000024854.1 ENSMUST00000024854.2 ENSMUST00000024854.3 ENSMUST00000024854.4 ENSMUST00000024854.5 ENSMUST00000024854.6 ENSMUST00000024854.7 ENSMUST00000024854.8 NM_030179 Q8BW09 Q8CI96 Q921Q4 Q9D2S6 Rsnl2 uc008dna.1 uc008dna.2 uc008dna.3 uc008dna.4 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CI96-1; Sequence=Displayed; Name=2; IsoId=Q8CI96-2; Sequence=VSP_012975, VSP_012976; Name=3; IsoId=Q8CI96-3; Sequence=VSP_012973, VSP_012974; molecular_function biological_process intracellular membrane-bounded organelle uc008dna.1 uc008dna.2 uc008dna.3 uc008dna.4 
ENSMUST00000024857.14 Lbh ENSMUST00000024857.14 limb-bud and heart (from RefSeq NM_029999.4) ENSMUST00000024857.1 ENSMUST00000024857.10 ENSMUST00000024857.11 ENSMUST00000024857.12 ENSMUST00000024857.13 ENSMUST00000024857.2 ENSMUST00000024857.3 ENSMUST00000024857.4 ENSMUST00000024857.5 ENSMUST00000024857.6 ENSMUST00000024857.7 ENSMUST00000024857.8 ENSMUST00000024857.9 LBH_MOUSE NM_029999 Q99MQ2 Q9CX60 uc008dng.1 uc008dng.2 uc008dng.3 uc008dng.4 Modulates the activity of key transcription factors involved in cardiogenesis. Nucleus Cytoplasm Expressed at highest levels in heart, and at lower levels in brain, spleen, lung, liver and kidney. First detected at 7.5 dpc in the mesendoderm that forms the anterior gut and the heart. At midgestation, expressed in the limb bud ectoderm and other specialized epithelia, as well as in the branchial arches and some neural crest derivatives. In the heart, expression initiates in the myocardial plate at the presomitic stage, with highest levels in the anterior myocardium. During heart chamber formation, expressed transiently in the right ventricle, atrioventricular canal and inflow tract. In the limb bud, expression is restricted to the ventral ectodermal compartment and the apical ectodermal ridge. Mice overexpressing Lbh in heart exhibit severe cardiac abnormalities and dysfunction. Belongs to the LBH family. nucleus cytoplasm regulation of transcription, DNA-templated multicellular organism development regulation of gene expression mammary gland development macromolecular complex negative regulation of intracellular estrogen receptor signaling pathway regulation of MAPK cascade negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated mammary gland epithelial cell differentiation positive regulation of somatic stem cell population maintenance positive regulation of somatic stem cell division positive regulation of mammary stem cell proliferation negative regulation of stem cell differentiation uc008dng.1 uc008dng.2 uc008dng.3 uc008dng.4 
ENSMUST00000024858.12 Galnt14 ENSMUST00000024858.12 polypeptide N-acetylgalactosaminyltransferase 14 (from RefSeq NM_027864.2) ENSMUST00000024858.1 ENSMUST00000024858.10 ENSMUST00000024858.11 ENSMUST00000024858.2 ENSMUST00000024858.3 ENSMUST00000024858.4 ENSMUST00000024858.5 ENSMUST00000024858.6 ENSMUST00000024858.7 ENSMUST00000024858.8 ENSMUST00000024858.9 Galnt14 NM_027864 Q08EC9 Q08EC9_MOUSE uc008dnk.1 uc008dnk.2 uc008dnk.3 uc008dnk.4 Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Golgi membrane Golgi apparatus protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups carbohydrate binding uc008dnk.1 uc008dnk.2 uc008dnk.3 uc008dnk.4 
ENSMUST00000024860.9 Ehd3 ENSMUST00000024860.9 EH-domain containing 3 (from RefSeq NM_020578.3) EHD3_MOUSE ENSMUST00000024860.1 ENSMUST00000024860.2 ENSMUST00000024860.3 ENSMUST00000024860.4 ENSMUST00000024860.5 ENSMUST00000024860.6 ENSMUST00000024860.7 ENSMUST00000024860.8 Ehd2 Ehd3 NM_020578 Q8K590 Q9QXY6 uc008dnn.1 uc008dnn.2 uc008dnn.3 uc008dnn.4 ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes (By similarity). Binding to phosphatidic acid induces its membrane tubulation activity (PubMed:26896729). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (By similarity). Involved in the recycling of internalized D1 dopamine receptor (By similarity). Plays a role in cardiac protein trafficking probably implicating ANK2. Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (PubMed:20489164, PubMed:24759929, PubMed:25825486). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (PubMed:21408024). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with Ehd1 (PubMed:25686250). Homooligomer. Heterooligomer with EHD1 (PubMed:12121420). Heterooligomer with EHD2 and EHD4; ATP-binding is required for heterooligomerization (By similarity). Interacts with PACSIN1 (PubMed:15930129). Interacts with PACSIN2 (PubMed:15930129). Interacts (via EH domain) with MICALL1 (By similarity). Interacts (via EH domain) with RAB11FIP2 (By similarity). Interacts with ANK2 (By similarity). Interacts with CACNA1GG and CACNA1H (PubMed:25825486). Q9QXY6; Q9H4M9: EHD1; Xeno; NbExp=7; IntAct=EBI-775304, EBI-490691; Q9QXY6; Q9NZN3: EHD3; Xeno; NbExp=5; IntAct=EBI-775304, EBI-2870749; Recycling endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, cilium membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle Note=Localizes to the ciliary pocket from where the cilium protrudes (By similarity). Colocalizes with RAB8A and MYO5B to a cytoplasmic tubular network devoid of RAB11A (PubMed:17507647). Colocalizes with ANK2 in myocyte perinuclear region (PubMed:25825486). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (PubMed:24373286). Strong expression seen in the kidney, brain and liver. In the kidney, expressed exclusively by glomerular endothelial cells; at protein level. Expressed in skeletal muscle neuromuscular junction perisynaptic region; at protein level. The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily. nucleotide binding receptor recycling calcium ion binding protein binding ATP binding GTP binding cytoplasm endosome cytosol plasma membrane cilium lipid binding protein transport membrane ciliary pocket membrane cell projection organization endocytic vesicle cytoplasmic vesicle endocytic recycling early endosome to Golgi transport cell projection myelin sheath metal ion binding perinuclear region of cytoplasm protein homooligomerization recycling endosome membrane regulation of cardiac muscle contraction ciliary membrane cilium assembly protein localization to plasma membrane regulation of cardiac muscle cell membrane potential Golgi to lysosome transport positive regulation of voltage-gated calcium channel activity regulation of Golgi organization regulation of cardiac conduction uc008dnn.1 uc008dnn.2 uc008dnn.3 uc008dnn.4 
ENSMUST00000024866.6 Xdh ENSMUST00000024866.6 xanthine dehydrogenase, transcript variant 1 (from RefSeq NM_011723.3) E9QLM9 ENSMUST00000024866.1 ENSMUST00000024866.2 ENSMUST00000024866.3 ENSMUST00000024866.4 ENSMUST00000024866.5 NM_011723 Q00519 XDH_MOUSE uc008dno.1 uc008dno.2 uc008dno.3 uc008dno.4 This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein exists as two distinct enzymatic forms, either as xanthine dehydrogenase, or as xanthine oxidase, and functions in purine degradation. Additional studies also suggest a role in adipogenesis, and a function as a structural protein in milk fat droplets in the lactating mammary gland. [provided by RefSeq, Jan 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK144700.1, AK143412.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## multifunctional gene product(s) :: PMID: 12502743, 15878860 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Reaction=H2O + NAD(+) + xanthine = H(+) + NADH + urate; Xref=Rhea:RHEA:16669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17712, ChEBI:CHEBI:17775, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.17.1.4; Evidence=; Reaction=H2O + hypoxanthine + NAD(+) = H(+) + NADH + xanthine; Xref=Rhea:RHEA:24670, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17368, ChEBI:CHEBI:17712, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.17.1.4; Evidence=; Reaction=H2O + O2 + xanthine = H2O2 + urate; Xref=Rhea:RHEA:21132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17712, ChEBI:CHEBI:17775; EC=1.17.3.2; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Evidence=; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. ; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 2 [2Fe-2S] clusters per subunit. ; Can be converted from the dehydrogenase form (D) to the oxidase form (O) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups. Homodimer. Interacts with BTN1A1. Cytoplasm Peroxisome Secreted By interferon. Subject to partial proteolysis; this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O). Contains sulfhydryl groups that are easily oxidized (in vitro); this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O). Belongs to the xanthine dehydrogenase family. negative regulation of protein phosphorylation negative regulation of endothelial cell proliferation xanthine dehydrogenase activity xanthine oxidase activity iron ion binding protein binding extracellular region extracellular space cytoplasm peroxisome cytosol hypoxanthine oxidation activation of cysteine-type endopeptidase activity involved in apoptotic process lactation electron carrier activity xanthine catabolic process response to aluminum ion negative regulation of gene expression oxidoreductase activity sarcoplasmic reticulum electron transport chain molybdenum ion binding regulation of epithelial cell differentiation protein homodimerization activity molybdopterin cofactor binding negative regulation of endothelial cell differentiation metal ion binding nitrite reductase (NO-forming) activity flavin adenine dinucleotide binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding negative regulation of protein kinase B signaling oxidation-reduction process FAD binding positive regulation of p38MAPK cascade negative regulation of vascular endothelial growth factor signaling pathway positive regulation of reactive oxygen species metabolic process negative regulation of vasculogenesis uc008dno.1 uc008dno.2 uc008dno.3 uc008dno.4 
ENSMUST00000024869.8 Spast ENSMUST00000024869.8 spastin, transcript variant 1 (from RefSeq NM_001162870.2) ENSMUST00000024869.1 ENSMUST00000024869.2 ENSMUST00000024869.3 ENSMUST00000024869.4 ENSMUST00000024869.5 ENSMUST00000024869.6 ENSMUST00000024869.7 Kiaa1083 NM_001162870 Q6ZPY6 Q80VE0 Q9CVK0 Q9QYY8 SPAST_MOUSE Spast Spg4 uc008doa.1 uc008doa.2 uc008doa.3 uc008doa.4 ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:19141076, PubMed:20530212). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Severing activity is not dependent on tubulin acetylation or detyrosination (By similarity). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation (By similarity). It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia (By similarity). SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (By similarity). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (By similarity). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (By similarity). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (By similarity). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (By similarity). Probably plays a role in axon growth and the formation of axonal branches (PubMed:18234839). [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence=; Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits. Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1. Membrane ; Peripheral membrane protein Endoplasmic reticulum Midbody Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton Cytoplasm, perinuclear region Nucleus Cytoplasm, cytoskeleton, spindle Cytoplasm ll projection, axon Note=Forms an intramembrane hairpin-like structure in the membrane. Localization to the centrosome is independent of microtubules. Localizes to the midbody of dividing cells, and this requires CHMP1B (By similarity). Enriched in the distal axons and branches of postmitotic neurons (By similarity). Evenly distributed along early axons and concentrates in the growth cone of the axons of late stage 3 neurons (PubMed:18234839). Mainly nuclear in interphase cells and becomes associated with the centrosomes, spindle microtubules, midzone and finally the midbody during cell division (By similarity). [Isoform 1]: Endoplasmic reticulum membrane ; Peripheral membrane protein Nucleus membrane Lipid droplet Cytoplasm, cytoskeleton Endosome Note=Forms an intramembrane hairpin- like structure in the membrane. Recruited to nuclear membrane by IST1 during late anaphase. Localizes to endoplasmic reticulum tubular network. [Isoform 2]: Cytoplasm Endosome Nucleus membrane Note=Constitutes the main endosomal form. Recruited to nuclear membrane by IST1 during late anaphase. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=68 kDa , M1 ; IsoId=Q9QYY8-1; Sequence=Displayed; Name=2; Synonyms=Short, Short variant 1, 60 kDa , M87 ; IsoId=Q9QYY8-2; Sequence=VSP_058335; Expressed in brain, heart, liver, lung, skeletal muscle, spinal cord, spleen and testis. Expressed is decreased following activation of the Notch pathway by JAG1/Jagged1. Mice develop gait abnormalities that correlate with phenotypes seen in hereditary spastic paraplegia (HSP) patients (PubMed:19453301). Adults are sterile (PubMed:17101632). Progressive axonal degeneration characterized by focal axonal swellings and the accumulation of organelles and cytoskeletal components, which is suggestive of impaired axonal transport (PubMed:17101632, PubMed:19453301). Primary cortical neurons develop swellings at the border between stable and dynamic microtubules (PubMed:17101632). In neurons with axonal swellings, the mitochondrial axonal transport defects are exacerbated: distal to axonal swellings both anterograde and retrograde transport are severely reduced (PubMed:19453301). In cortical neurons, axonal swellings is probably due to impaired microtubule dynamics all along the axons (PubMed:22773755). Belongs to the AAA ATPase family. Spastin subfamily. nucleotide binding mitotic cytokinesis microtubule bundle formation catalytic activity ATP binding nucleus nucleoplasm cytoplasm endosome endoplasmic reticulum endoplasmic reticulum membrane lipid particle centrosome microtubule organizing center spindle cytosol cytoskeleton microtubule ER to Golgi vesicle-mediated transport cell cycle multicellular organism development nervous system development axonogenesis microtubule binding anterograde axonal transport metabolic process microtubule-severing ATPase activity exit from mitosis microtubule cytoskeleton membrane integral component of membrane isomerase activity ATPase activity axonal transport of mitochondrion cell differentiation midbody positive regulation of microtubule depolymerization cytoplasmic microtubule organization cytoplasmic vesicle nuclear envelope reassembly nuclear membrane positive regulation of cytokinesis cytokinetic process protein hexamerization alpha-tubulin binding perinuclear region of cytoplasm beta-tubulin binding microtubule severing mitotic spindle disassembly protein homooligomerization cell division endoplasmic reticulum tubular network membrane fission axon cytoplasm uc008doa.1 uc008doa.2 uc008doa.3 uc008doa.4 
ENSMUST00000024870.9 Slc30a6 ENSMUST00000024870.9 solute carrier family 30 (zinc transporter), member 6, transcript variant 2 (from RefSeq NM_144798.6) ENSMUST00000024870.1 ENSMUST00000024870.2 ENSMUST00000024870.3 ENSMUST00000024870.4 ENSMUST00000024870.5 ENSMUST00000024870.6 ENSMUST00000024870.7 ENSMUST00000024870.8 NM_144798 Q3UB35 Q6NVE0 Q8BJM5 Q8K4H6 Q8R4Z2 Q99JQ3 ZNT6_MOUSE Znt6 uc008dob.1 uc008dob.2 uc008dob.3 uc008dob.4 Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (Probable). As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (By similarity). Heterodimer with SLC30A5; form a functional zinc ion transmembrane transporter. Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Expressed in brain and liver, and to a lower extent also in lung. Highly expressed in brain (at protein level). Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. Hydrophilic histidine residues that participate to zinc binding in transporters of the family are not conserved in SLC30A6. Sequence=AAH05753.1; Type=Erroneous initiation; Evidence=; zinc ion transmembrane transporter activity mitochondrion Golgi apparatus cytosol ion transport cation transport zinc II ion transport Golgi to endosome transport cation transmembrane transporter activity membrane integral component of membrane transmembrane transport zinc II ion transmembrane transport cation transmembrane transport uc008dob.1 uc008dob.2 uc008dob.3 uc008dob.4 
ENSMUST00000024873.7 Yipf4 ENSMUST00000024873.7 Yip1 domain family, member 4 (from RefSeq NM_026417.4) ENSMUST00000024873.1 ENSMUST00000024873.2 ENSMUST00000024873.3 ENSMUST00000024873.4 ENSMUST00000024873.5 ENSMUST00000024873.6 NM_026417 Q8C407 Q99KZ9 YIPF4_MOUSE uc008dod.1 uc008dod.2 uc008dod.3 Involved in the maintenance of the Golgi structure. Interacts with YIPF3 and YIPF5. Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C407-1; Sequence=Displayed; Name=2; IsoId=Q8C407-2; Sequence=VSP_019457; Belongs to the YIP1 family. molecular_function endoplasmic reticulum Golgi apparatus plasma membrane biological_process membrane integral component of membrane intracellular membrane-bounded organelle uc008dod.1 uc008dod.2 uc008dod.3 
ENSMUST00000024880.11 Vit ENSMUST00000024880.11 vitrin, transcript variant 1 (from RefSeq NM_028813.2) Akh ENSMUST00000024880.1 ENSMUST00000024880.10 ENSMUST00000024880.2 ENSMUST00000024880.3 ENSMUST00000024880.4 ENSMUST00000024880.5 ENSMUST00000024880.6 ENSMUST00000024880.7 ENSMUST00000024880.8 ENSMUST00000024880.9 NM_028813 Q3TZ47 Q8BQ41 Q8K047 Q8VHI5 Q9CYZ1 VITRN_MOUSE uc008dox.1 uc008dox.2 uc008dox.3 uc008dox.4 Promotes matrix assembly and cell adhesiveness (PubMed:18757743). Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells (PubMed:25331329). Binds dermatan sulfate and chondroitin sulfate. Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VHI5-1; Sequence=Displayed; Name=2; IsoId=Q8VHI5-2; Sequence=VSP_020212; At 16.5 dpc, present in skull base cartilage (at protein level) (PubMed:18757743). Expressed in the floor plate as early as 9.5 dpc and shifted to the central canal area from 13.5 dpc. At 15.5 dpc, the expression is restricted to the ventral midline region (PubMed:25331329). Highly up-regulated in the injured spinal cord. Embryos show decreased spinal cord size associated with reduced cell proliferation and altered cell differentiation in the central canal of the neural tube. growth plate cartilage chondrocyte morphogenesis glycosaminoglycan binding extracellular region interstitial matrix extracellular space nervous system development positive regulation of cell-substrate adhesion spinal cord development extracellular matrix organization extracellular matrix uc008dox.1 uc008dox.2 uc008dox.3 uc008dox.4 
ENSMUST00000024882.8 Ttc27 ENSMUST00000024882.8 tetratricopeptide repeat domain 27 (from RefSeq NM_152817.4) ENSMUST00000024882.1 ENSMUST00000024882.2 ENSMUST00000024882.3 ENSMUST00000024882.4 ENSMUST00000024882.5 ENSMUST00000024882.6 ENSMUST00000024882.7 NM_152817 Q3THU0 Q8C7S8 Q8CD92 Q8K1D9 TTC27_MOUSE uc008dok.1 uc008dok.2 uc008dok.3 uc008dok.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CD92-1; Sequence=Displayed; Name=2; IsoId=Q8CD92-2; Sequence=VSP_026720; Belongs to the TTC27 family. Sequence=AAH21912.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc008dok.1 uc008dok.2 uc008dok.3 uc008dok.4 
ENSMUST00000024884.5 Eif2ak2 ENSMUST00000024884.5 eukaryotic translation initiation factor 2-alpha kinase 2 (from RefSeq NM_011163.4) E2AK2_MOUSE ENSMUST00000024884.1 ENSMUST00000024884.2 ENSMUST00000024884.3 ENSMUST00000024884.4 NM_011163 Pkr Prkr Q03963 Q61742 Q62026 Tik uc008dph.1 uc008dph.2 uc008dph.3 uc008dph.4 IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:20038207, PubMed:20478537, PubMed:21123651). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:21123651, PubMed:20631127). Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV) (PubMed:19264662, PubMed:20585572, PubMed:20631127, PubMed:21994357). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, and IRS1 (PubMed:19229320, PubMed:23403623). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (By similarity). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF- kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948222, PubMed:23392680). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (By similarity). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (By similarity). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (By similarity). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494, PubMed:23401008). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (PubMed:22633459). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Initially produced in an inactive form and is activated by binding to viral dsRNA, which causes dimerization and autophosphorylation in the activation loop and stimulation of function. ISGylation can activate it in the absence of viral infection. Can also be activated by heparin, pro-inflammatory stimuli, growth factors, cytokines, oxidative stress and the cellular protein PRKRA. Activity is markedly stimulated by manganese ions. Activation is blocked by the cellular proteins TARBP2, DUS2L, NPM1, NCK1 and ADAR (By similarity). Homodimer. Interacts with DNAJC3 and STRBP (By similarity). Forms a complex with FANCA, FANCC, FANCG and HSP70 (By similarity). Interacts with ADAR/ADAR1. The inactive form interacts with NCK1. Interacts (via the kinase catalytic domain) with STAT3 (via SH2 domain), TRAF2 (C-terminus), TRAF5 (C-terminus) and TRAF6 (C-terminus). Interacts with MAP2K6, TARBP2, NLRP1, NLRC4 and AIM2. Interacts (via DRBM 1 domain) with DUS2L (via DRBM domain) (By similarity). Interacts with DHX9 (via N-terminus) and this interaction is dependent upon activation of the kinase. The inactive form interacts with GSN. Interacts with IKBKB/IKKB, NPM1, NLRP3 and IRS1. Q03963; P35569: Irs1; NbExp=2; IntAct=EBI-2603444, EBI-400825; Q03963; Q8R4B8: Nlrp3; NbExp=3; IntAct=EBI-2603444, EBI-6910832; Cytoplasm Nucleus Cytoplasm, perinuclear region Expressed in heart, lung, brain, kidney, testes, thymus and bone marrow. By type I interferons. Autophosphorylated on several Ser, Thr and Tyr residues. Autophosphorylation of Thr-414 is dependent on Thr-409 and is stimulated by dsRNA binding and dimerization. Autophosphorylation apparently leads to the activation of the kinase. Tyrosine autophosphorylation is essential for efficient dsRNA-binding, dimerization, and kinase activation (By similarity). Mice have significantly elevated numbers of bone marrow derived hematopoietic stem/progenitor cells (HSPCs) and which are more actively proliferating and resistant to stress. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. nucleotide binding activation of MAPKK activity positive regulation of cytokine production immune system process RNA binding double-stranded RNA binding protein kinase activity protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding nucleus cytoplasm cytosol translation protein phosphorylation response to virus response to toxic substance regulation of translational initiation by eIF2 alpha phosphorylation kinase activity phosphorylation transferase activity negative regulation of translation peptidyl-tyrosine phosphorylation endoplasmic reticulum unfolded protein response response to lipopolysaccharide positive regulation of chemokine production positive regulation of stress-activated MAPK cascade response to vitamin E negative regulation of osteoblast proliferation cellular response to amino acid starvation response to interferon-alpha identical protein binding positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of viral genome replication innate immune response protein autophosphorylation perinuclear region of cytoplasm positive regulation of NF-kappaB transcription factor activity defense response to virus regulation of NLRP3 inflammasome complex assembly positive regulation of NIK/NF-kappaB signaling regulation of hematopoietic progenitor cell differentiation regulation of hematopoietic stem cell proliferation regulation of hematopoietic stem cell differentiation uc008dph.1 uc008dph.2 uc008dph.3 uc008dph.4 
ENSMUST00000024885.10 Cebpz ENSMUST00000024885.10 CCAAT/enhancer binding protein zeta (from RefSeq NM_001024806.2) A0A0R4J046 A0A0R4J046_MOUSE Cebpz ENSMUST00000024885.1 ENSMUST00000024885.2 ENSMUST00000024885.3 ENSMUST00000024885.4 ENSMUST00000024885.5 ENSMUST00000024885.6 ENSMUST00000024885.7 ENSMUST00000024885.8 ENSMUST00000024885.9 NM_001024806 uc008dpk.1 uc008dpk.2 uc008dpk.3 Belongs to the CBF/MAK21 family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleus ribosome biogenesis positive regulation of transcription from RNA polymerase II promoter uc008dpk.1 uc008dpk.2 uc008dpk.3 
ENSMUST00000024887.6 Ndufaf7 ENSMUST00000024887.6 NADH:ubiquinone oxidoreductase complex assembly factor 7 (from RefSeq NM_028611.3) E9QLM6 ENSMUST00000024887.1 ENSMUST00000024887.2 ENSMUST00000024887.3 ENSMUST00000024887.4 ENSMUST00000024887.5 NDUF7_MOUSE NM_028611 Ndufaf7 Q8C1X3 Q9CWG8 uc008dpn.1 uc008dpn.2 uc008dpn.3 uc008dpn.4 Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex. Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:48108, Rhea:RHEA-COMP:10532, Rhea:RHEA- COMP:11992, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:88221; EC=2.1.1.320; Evidence=; Interacts with NDUFS2. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CWG8-1; Sequence=Displayed; Name=2; IsoId=Q9CWG8-2; Sequence=VSP_030608; Embryonic lethality. Belongs to the NDUFAF7 family. mitochondrion methyltransferase activity transferase activity enzyme binding peptidyl-arginine methylation, to symmetrical-dimethyl arginine methylation mitochondrial respiratory chain complex I assembly protein-arginine omega-N symmetric methyltransferase activity uc008dpn.1 uc008dpn.2 uc008dpn.3 uc008dpn.4 
ENSMUST00000024894.2 Cyp1b1 ENSMUST00000024894.2 cytochrome P450, family 1, subfamily b, polypeptide 1, transcript variant 1 (from RefSeq NM_009994.2) CP1B1_MOUSE Cyp1-b1 Cyp1b1 ENSMUST00000024894.1 NM_009994 Q3UVA8 Q60593 Q64429 Q64461 uc008dqc.1 uc008dqc.2 A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (By similarity). Exhibits catalytic activity for the formation of hydroxyestrogens from 17beta-estradiol (E2), namely 2- and 4-hydroxy E2 (PubMed:23821647). Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites (By similarity). May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:15258110). Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system (PubMed:15258110). Additionally, displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 (By similarity). Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products (By similarity). Plays an important role in retinal vascular development. Under ambient/hyperoxic O2 conditions, promotes angiogenesis and capillary morphogenesis of retinal endothelial cells and pericytes, likely by metabolizing the oxygenated products symptomatic of oxidative stress (PubMed:19005183, PubMed:20032512, PubMed:23568032). Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression (PubMed:23979599). Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence=; Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:47212, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:28744, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47213; Evidence=; Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:47280, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62845; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47281; Evidence=; Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2- hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47208, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:1156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47209; Evidence=; Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4- hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47292, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87602; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47293; Evidence=; Reaction=O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46296, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17347, ChEBI:CHEBI:34477, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46297; Evidence=; Reaction=O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47252, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17026, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62117; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47253; Evidence=; Reaction=O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:47260, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15826, ChEBI:CHEBI:17026, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47261; Evidence=; Reaction=all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:42092, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42093; Evidence=; Reaction=all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:42088, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42089; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49884, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49885; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49880, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131970; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49881; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49876, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131969; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49877; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131965; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49861; Evidence=; Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo- (6E,8Z,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48632, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:65342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48633; Evidence=; Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo- (5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37947, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37948; Evidence=; Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)- octadecadienoate + H2O; Xref=Rhea:RHEA:48716, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:90781; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48717; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo- (5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48637; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Enzyme activity is increased by cytochrome b5 (PubMed:23821647). Enzyme activity is increased by liposomes containing anionic phospholipids, phosphatidic acid and cardiolipin. Inhibited by naringenin with an IC(50) of 5 uM (By similarity). Kinetic parameters: KM=392.2 uM for all-trans-retinol ; KM=153.9 uM for all-trans-retinal ; KM=138.9 uM for 7,12-dimethyltetraphene ; KM=500.0 uM for arachidonic acid ; Note=kcat is 0.04 min(-1) for retinol, 0.08 min(-1) for retinal, 1.24 min(-1) for 7,12-dimethyltetraphene, 0.13 min(-1) for arachidonic acid.; Steroid hormone biosynthesis. Cofactor metabolism; retinol metabolism. Lipid metabolism; arachidonate metabolism. Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Mitochondrion Note=Located primarily in endoplasmic reticulum. Upon treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), CYP1B1 is also targeted to mitochondria. Constitutively expressed in retinal and kidney pericytes cells (PubMed:23568032). Expressed in retinal endothelial cells (at protein level). Expressed in cardiac, pulmonary and aortic endothelial cells (PubMed:19005183). Constitutively expressed in trabecular meshwork of the eye (at protein level) (PubMed:23979599). Up-regulated by polycyclic aromatic hydrocarbons (PAH) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Severe ocular drainage structure abnormalities, significant elevated intraocular pressure. Belongs to the cytochrome P450 family. angiogenesis trabecular meshwork development monooxygenase activity iron ion binding nucleus mitochondrion endoplasmic reticulum endoplasmic reticulum membrane DNA modification lipid metabolic process fatty acid metabolic process cellular aromatic compound metabolic process xenobiotic metabolic process nitric oxide biosynthetic process cell adhesion steroid metabolic process estrogen metabolic process negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to oxidative stress toxin metabolic process response to toxic substance positive regulation of vascular endothelial growth factor production positive regulation of smooth muscle cell migration membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen lyase activity arachidonic acid metabolic process heme binding collagen fibril organization negative regulation of cell migration organelle membrane negative regulation of NF-kappaB transcription factor activity negative regulation of cell adhesion mediated by integrin benzene-containing compound metabolic process retinol metabolic process retinal metabolic process positive regulation of apoptotic process intracellular membrane-bounded organelle endothelial cell migration positive regulation of translation positive regulation of angiogenesis positive regulation of JAK-STAT cascade membrane lipid catabolic process metal ion binding blood vessel morphogenesis oxidation-reduction process retina vasculature development in camera-type eye retinal blood vessel morphogenesis cellular response to hydrogen peroxide aromatase activity cellular response to organic cyclic compound endothelial cell-cell adhesion estrogen 16-alpha-hydroxylase activity regulation of reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process dibenzo-p-dioxin metabolic process uc008dqc.1 uc008dqc.2 
ENSMUST00000024896.4 4930583I09Rik ENSMUST00000024896.4 RIKEN cDNA 4930583I09 gene (from RefSeq NM_030031.1) 4930583I09Rik ENSMUST00000024896.1 ENSMUST00000024896.2 ENSMUST00000024896.3 NM_030031 Q9D2E3 Q9D2E3_MOUSE uc057kyj.1 uc057kyj.2 uc057kyj.3 molecular_function cellular_component biological_process uc057kyj.1 uc057kyj.2 uc057kyj.3 
ENSMUST00000024897.10 Vapa ENSMUST00000024897.10 vesicle-associated membrane protein, associated protein A, transcript variant 2 (from RefSeq NM_013933.3) ENSMUST00000024897.1 ENSMUST00000024897.2 ENSMUST00000024897.3 ENSMUST00000024897.4 ENSMUST00000024897.5 ENSMUST00000024897.6 ENSMUST00000024897.7 ENSMUST00000024897.8 ENSMUST00000024897.9 NM_013933 Q3TJM1 Q9QY77 Q9WV55 VAPA_MOUSE Vap33 Vapa uc008dgd.1 uc008dgd.2 uc008dgd.3 uc008dgd.4 Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3- VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. Homodimer; disulfide-linked. Heterodimer with VAPB. Homotetramer. Interacts with VAMP1, VAMP2, STX1A, BET1, SEC22C and with the C-terminal domain of OCLN. Interacts (via MSP domain) with OSBPL1A (via FFAT motif) (By similarity). Interacts (via MSP domain) with ZFYVE27; may retain ZFYVE27 in the endoplasmic reticulum and regulate its function in cell projections formation (PubMed:24251978). Interacts with OSBP. Interacts (via C-terminus) with RSAD2/viperin (via C- terminus). Interacts with IFITM3. Interacts with OSBPL3 (phosphorylated form). Interacts with KIF5A in a ZFYVE27-dependent manner. Interacts (via MSP domain) with STARD3 (via phosphorylated FFAT motif); this interaction recruits VAPA to the endosome. Interacts with STARD3NL (via FFAT motif). Interacts with CERT1. Interacts with PLEKHA3 and SACM1L to form a ternary complex. Interacts with VPS13A (via FFAT motif). Interacts with RB1CC1 (via phosphorylated FFAT motif), MIGA2 (via phosphorylated FFAT motif), RMDN3 (via phosphorylated FFAT motif), KCNB1 (via phosphorylated FFAT motif) and KCNB2 (via phosphorylated FFAT motif) (By similarity). Interacts (via MSP domain) with WDR44 (via FFAT-like motif); the interactions connect the endoplasmic reticulum (ER) with the endosomal tubule (By similarity). Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Cell membrane ; Single-pass type IV membrane protein Cell junction, tight junction Nucleus membrane Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells. Ubiquitous. The MSP domain binds the FFAT motif of many proteins. Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. Sequence=AAD45320.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB22868.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi membrane protein binding nucleus endoplasmic reticulum endoplasmic reticulum membrane plasma membrane bicellular tight junction ER to Golgi vesicle-mediated transport microtubule binding cell death microtubule cytoskeleton membrane integral component of membrane protein domain specific binding cell junction neuron projection development nuclear membrane vesicle FFAT motif binding identical protein binding positive regulation by host of viral release from host cell negative regulation by host of viral genome replication positive regulation by host of viral genome replication protein heterodimerization activity perinuclear region of cytoplasm protein localization to endoplasmic reticulum COPII-coated vesicle budding uc008dgd.1 uc008dgd.2 uc008dgd.3 uc008dgd.4 
ENSMUST00000024914.4 Themis3 ENSMUST00000024914.4 thymocyte selection associated family member 3 (from RefSeq NM_028998.2) ENSMUST00000024914.1 ENSMUST00000024914.2 ENSMUST00000024914.3 NM_028998 Q9CU24 THMS3_MOUSE uc008djz.1 uc008djz.2 uc008djz.3 uc008djz.4 Specifically expressed in the intestine. Belongs to the themis family. molecular_function nucleus cytoplasm T cell receptor signaling pathway uc008djz.1 uc008djz.2 uc008djz.3 uc008djz.4 
ENSMUST00000024916.7 Lhcgr ENSMUST00000024916.7 luteinizing hormone/choriogonadotropin receptor, transcript variant 2 (from RefSeq NR_157357.1) ENSMUST00000024916.1 ENSMUST00000024916.2 ENSMUST00000024916.3 ENSMUST00000024916.4 ENSMUST00000024916.5 ENSMUST00000024916.6 LSHR_MOUSE Lhr NR_157357 P30730 uc008dvw.1 uc008dvw.2 uc008dvw.3 Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Cell membrane ; Multi-pass membrane protein Sulfated. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. ovarian follicle development G-protein coupled receptor activity luteinizing hormone receptor activity extracellular space nucleus cytoplasm lysosome endosome endoplasmic reticulum plasma membrane integral component of plasma membrane protein targeting to lysosome signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity phospholipase C-activating G-protein coupled receptor signaling pathway spermatogenesis G-protein coupled peptide receptor activity male gonad development female gonad development hormone-mediated signaling pathway positive regulation of calcium ion transport into cytosol membrane integral component of membrane protein-hormone receptor activity peptide hormone binding ovulation cycle process intrinsic component of external side of plasma membrane positive regulation of inositol trisphosphate biosynthetic process response to luteinizing hormone choriogonadotropin hormone receptor activity choriogonadotropin hormone binding luteinizing hormone signaling pathway identical protein binding protein homodimerization activity receptor complex development of secondary male sexual characteristics positive regulation of hormone biosynthetic process arachidonic acid secretion positive regulation of calcium-mediated signaling cognition ATPase binding positive regulation of release of sequestered calcium ion into cytosol uterus development cellular response to gonadotropin stimulus cellular response to luteinizing hormone stimulus seminiferous tubule development regulation of steroid hormone biosynthetic process uc008dvw.1 uc008dvw.2 uc008dvw.3 
ENSMUST00000024926.14 Prss41 ENSMUST00000024926.14 serine protease 41, transcript variant 1 (from RefSeq NM_027644.2) ENSMUST00000024926.1 ENSMUST00000024926.10 ENSMUST00000024926.11 ENSMUST00000024926.12 ENSMUST00000024926.13 ENSMUST00000024926.2 ENSMUST00000024926.3 ENSMUST00000024926.4 ENSMUST00000024926.5 ENSMUST00000024926.6 ENSMUST00000024926.7 ENSMUST00000024926.8 ENSMUST00000024926.9 NM_027644 PRS41_MOUSE Prss41 Q8BX01 Q920S2 Tessp1 uc008atv.1 uc008atv.2 uc008atv.3 Cell membrane ipid-anchor, GPI-anchor Note=Localized in the plasma membrane of spermatogonia. Localized in intracellular compartment in spermatocytes, probably in the Golgi apparatus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q920S2-1; Sequence=Displayed; Name=2; IsoId=Q920S2-2; Sequence=VSP_034949, VSP_034950; Testis-specific. Expressed in spermatogonia and spermatocytes. Expressed in Leydig and Sertoli cells (at protein level). Expressed 2 weeks after birth and remains highly expressed in the sexually mature testis. Expressed in the seminiferous tubules but not in the interstitial tissues. Expressed in type B spermatogonia and spermatocytes at stages between preleptotene and pachytene during the spermatogenesis cycle. N-glycosylated. Belongs to the peptidase S1 family. serine-type endopeptidase activity plasma membrane proteolysis peptidase activity serine-type peptidase activity membrane hydrolase activity anchored component of membrane intracellular organelle uc008atv.1 uc008atv.2 uc008atv.3 
ENSMUST00000024928.4 Prss21 ENSMUST00000024928.4 serine protease 21 (from RefSeq NM_020487.4) ENSMUST00000024928.1 ENSMUST00000024928.2 ENSMUST00000024928.3 NM_020487 Q9DA14 Q9JHJ7 TEST_MOUSE uc008aty.1 uc008aty.2 uc008aty.3 uc008aty.4 Could regulate proteolytic events associated with testicular germ cell maturation. Cell membrane ; Lipid-anchor, GPI- anchor Testis. Expressed in post-meiotic testicular germ cells. Belongs to the peptidase S1 family. Sequence=AK006271; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; serine-type endopeptidase activity extracellular space plasma membrane proteolysis spermatogenesis peptidase activity serine-type peptidase activity membrane hydrolase activity anchored component of membrane uc008aty.1 uc008aty.2 uc008aty.3 uc008aty.4 
ENSMUST00000024930.8 Tedc2 ENSMUST00000024930.8 tubulin epsilon and delta complex 2 (from RefSeq NM_028056.2) ENSMUST00000024930.1 ENSMUST00000024930.2 ENSMUST00000024930.3 ENSMUST00000024930.4 ENSMUST00000024930.5 ENSMUST00000024930.6 ENSMUST00000024930.7 NM_028056 Q6GQV0 Q9DAZ6 TEDC2_MOUSE Tedc2 uc008avb.1 uc008avb.2 uc008avb.3 uc008avb.4 Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability. Interacts with TEDC1 (PubMed:29459677). Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1 (PubMed:29459677). Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6GQV0-1; Sequence=Displayed; Name=2; IsoId=Q6GQV0-2; Sequence=VSP_025089; molecular_function protein binding cellular_component centriole biological_process positive regulation of smoothened signaling pathway uc008avb.1 uc008avb.2 uc008avb.3 uc008avb.4 
ENSMUST00000024931.6 Ntn3 ENSMUST00000024931.6 netrin 3 (from RefSeq NM_010947.3) ENSMUST00000024931.1 ENSMUST00000024931.2 ENSMUST00000024931.3 ENSMUST00000024931.4 ENSMUST00000024931.5 NET3_MOUSE NM_010947 Ntn2l Q9QY49 Q9R1A3 Q9WVA6 uc008auy.1 uc008auy.2 uc008auy.3 uc008auy.4 uc008auy.5 Netrins control guidance of CNS commissural axons and peripheral motor axons. Secreted, extracellular space, extracellular matrix Very low levels at 10.5 to 12.5 dpc in dorsal root ganglia. High levels in motor neurons at 13.5, 14.5 and 15.5 dpc. At 11.5 dpc also expressed in the developing limb buds. receptor binding extracellular region basement membrane Golgi apparatus regulation of transcription, DNA-templated axonogenesis myoblast fusion motor neuron axon guidance animal organ morphogenesis tissue development dendrite development uc008auy.1 uc008auy.2 uc008auy.3 uc008auy.4 uc008auy.5 
ENSMUST00000024932.12 Atp6v0c ENSMUST00000024932.12 ATPase, H+ transporting, lysosomal V0 subunit C, transcript variant 3 (from RefSeq NM_009729.4) Atp6c Atp6l Atpl ENSMUST00000024932.1 ENSMUST00000024932.10 ENSMUST00000024932.11 ENSMUST00000024932.2 ENSMUST00000024932.3 ENSMUST00000024932.4 ENSMUST00000024932.5 ENSMUST00000024932.6 ENSMUST00000024932.7 ENSMUST00000024932.8 ENSMUST00000024932.9 Mvp NM_009729 P23967 P63082 Q3TD69 VATL_MOUSE uc008aup.1 uc008aup.2 uc008aup.3 uc008aup.4 uc008aup.5 Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with the V0 complex V-ATPase subunit a4 ATP6V0A4 (PubMed:11495928). Interacts with LASS2 (By similarity). Interacts with RNF182; this interaction leads to ubiquitination and degradation via the proteasome pathway (By similarity). Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway. Belongs to the V-ATPase proteolipid subunit family. protein binding lysosome vacuole vacuolar membrane Golgi apparatus ion transport vacuolar acidification lysosomal lumen acidification hydrogen-exporting ATPase activity, phosphorylative mechanism hydrogen ion transmembrane transporter activity membrane integral component of membrane vacuolar proton-transporting V-type ATPase complex positive regulation of Wnt signaling pathway ubiquitin protein ligase binding proton-transporting two-sector ATPase complex, proton-transporting domain proton-transporting V-type ATPase, V0 domain proton-transporting ATPase activity, rotational mechanism hydrogen ion transmembrane transport uc008aup.1 uc008aup.2 uc008aup.3 uc008aup.4 uc008aup.5 
ENSMUST00000024944.9 Slc3a1 ENSMUST00000024944.9 solute carrier family 3, member 1 (from RefSeq NM_009205.2) ENSMUST00000024944.1 ENSMUST00000024944.2 ENSMUST00000024944.3 ENSMUST00000024944.4 ENSMUST00000024944.5 ENSMUST00000024944.6 ENSMUST00000024944.7 ENSMUST00000024944.8 NM_009205 Nbat Q91WV7 SLC31_MOUSE Slc3a1 uc008dtl.1 uc008dtl.2 uc008dtl.3 Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heteromers to the plasma membrane (By similarity) (PubMed:26739563). Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L- cysteine. SLC7A9-SLC3A1 acts as a major transporter for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in early proximal tubules (By similarity). Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion. SLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L- glutamate or L-aspartate (PubMed:26739563). Disulfide-linked heterodimer composed of the catalytic light subunit SLC7A9 and the heavy subunit SLC3A1. The heterodimer is the minimal functional unit. Assembles in non-covalently linked heterotetramers (dimers of heterodimers) and higher order oligomers; the oligomerization is mediated by SLC3A1 likely to prevent degradation in the endoplasmic reticulum and facilitate heteromer trafficking to the plasma membrane (By similarity) (PubMed:12167606). Disulfide-linked heterodimer composed of the catalytic light subunit SLC7A13 and the heavy subunit SLC3A1 (PubMed:26739563). Cell membrane ; Single-pass type II membrane protein Apical cell membrane ; Single-pass type II membrane protein Expressed in the brush border membrane in the kidney (at protein level). Highly expressed in renal tubules in the outer stripe of the outer medulla and medullary ray (at protein level). Also detected in the renal cortex. More abundant in male than female kidneys. catalytic activity protein binding mitochondrial inner membrane vacuolar membrane plasma membrane integral component of plasma membrane carbohydrate metabolic process amino acid transport membrane integral component of membrane brush border membrane protein heterodimerization activity uc008dtl.1 uc008dtl.2 uc008dtl.3 
ENSMUST00000024954.11 Epas1 ENSMUST00000024954.11 endothelial PAS domain protein 1 (from RefSeq NM_010137.3) ENSMUST00000024954.1 ENSMUST00000024954.10 ENSMUST00000024954.2 ENSMUST00000024954.3 ENSMUST00000024954.4 ENSMUST00000024954.5 ENSMUST00000024954.6 ENSMUST00000024954.7 ENSMUST00000024954.8 ENSMUST00000024954.9 EPAS1_MOUSE Hif2a NM_010137 O08787 O55046 P97481 uc008duj.1 uc008duj.2 uc008duj.3 uc008duj.4 Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity). Interacts with HIF3A isoform 2 (PubMed:21546903). Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'- TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371). Interacts with CREBBP (PubMed:11983697). Interacts with EGLN1. Interacts with VHL (By similarity). P97481; P53762: Arnt; NbExp=5; IntAct=EBI-15704570, EBI-78852; Nucleus cleus speckle Note=Colocalizes with HIF3A isoform 2 in the nucleus and speckles. Expressed in most tissues, with highest levels in lung, followed by heart, kidney, brain and liver. Predominantly expressed in endothelial cells. Also found in smooth muscle cells of the uterus, neurons, and brown adipose tissue. High expression in embryonic choroid plexus and kidney glomeruli. In day 11 embryo, expression is almost exclusively seen in endothelial cells of the intersegmental blood vessels separating the somites, the atrial and ventricular chambers of the heart, and the dorsal aorta. High expression also occurs in extraembryonic membranes. In the developing brain of day 13 embryo, endothelial cells of the highly vascularized choroid plexus contain high levels of EPAS1. In normoxia, is probably hydroxylated on Pro-405 and Pro-530 by EGLN1/PHD1, EGLN2/PHD2 and/or EGLN3/PHD3. The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization (By similarity). In normoxia, is hydroxylated on Asn-851 by HIF1AN thus probably abrogating interaction with CREBBP and EP300 and preventing transcriptional activation. Phosphorylated on multiple sites in the CTAD. The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis response to hypoxia embryonic placenta development blood vessel remodeling regulation of heart rate DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter response to oxidative stress mitochondrion organization multicellular organism development visual perception transcription factor binding nuclear speck hemopoiesis cell differentiation erythrocyte differentiation lung development histone acetyltransferase binding norepinephrine metabolic process norepinephrine biosynthetic process surfactant homeostasis sequence-specific DNA binding regulation of transcription from RNA polymerase II promoter in response to oxidative stress positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity cell maturation myoblast fate commitment cobalt ion binding iron ion homeostasis cellular response to hypoxia positive regulation of dopamine biosynthetic process uc008duj.1 uc008duj.2 uc008duj.3 uc008duj.4 
ENSMUST00000024956.15 Rhoq ENSMUST00000024956.15 ras homolog family member Q (from RefSeq NM_145491.2) Arhq ENSMUST00000024956.1 ENSMUST00000024956.10 ENSMUST00000024956.11 ENSMUST00000024956.12 ENSMUST00000024956.13 ENSMUST00000024956.14 ENSMUST00000024956.2 ENSMUST00000024956.3 ENSMUST00000024956.4 ENSMUST00000024956.5 ENSMUST00000024956.6 ENSMUST00000024956.7 ENSMUST00000024956.8 ENSMUST00000024956.9 NM_145491 Q7TNC0 Q80VH4 Q8R527 RHOQ_MOUSE Tc10 uc008dum.1 uc008dum.2 uc008dum.3 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia (By similarity). Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Interacts with EXO70, CDC42EP1, CDC42EP2 and CDC42EP3 in a GTP-dependent manner (By similarity). Interacts with CDC42EP4, PARD6A, PARD6G (and probably PARD6B) in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ). Interacts with GOPC (By similarity). Interacts with ARHGAP33/TCGAP. Cytoplasm Cell membrane ; Lipid-anchor May be post-translationally modified by both palmitoylation and polyisoprenylation. Belongs to the small GTPase superfamily. Rho family. nucleotide binding GTPase activity protein binding profilin binding GTP binding cytoplasm actin filament plasma membrane cell cortex endocytosis actin filament organization establishment or maintenance of cell polarity small GTPase mediated signal transduction Rho protein signal transduction insulin receptor signaling pathway regulation of cell shape membrane protein kinase binding cell projection assembly actin cytoskeleton organization cortical actin cytoskeleton organization GBD domain binding cellular response to insulin stimulus regulation of actin cytoskeleton organization cell projection membrane raft positive regulation of transcription from RNA polymerase II promoter GTP metabolic process negative regulation of glucose import positive regulation of glucose import positive regulation of filopodium assembly negative regulation of protein localization to plasma membrane uc008dum.1 uc008dum.2 uc008dum.3 
ENSMUST00000024957.7 Pigf ENSMUST00000024957.7 phosphatidylinositol glycan anchor biosynthesis, class F, transcript variant 16 (from RefSeq NR_177248.1) ENSMUST00000024957.1 ENSMUST00000024957.2 ENSMUST00000024957.3 ENSMUST00000024957.4 ENSMUST00000024957.5 ENSMUST00000024957.6 NR_177248 O09101 PIGF_MOUSE uc008dun.1 uc008dun.2 uc008dun.3 Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI. Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Forms a complex with PIGG and PIGO. PIGF is required to stabilize PIGG and PIGO. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the PIGF family. endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process membrane integral component of membrane phosphotransferase activity, for other substituted phosphate groups uc008dun.1 uc008dun.2 uc008dun.3 
ENSMUST00000024958.9 Caskin1 ENSMUST00000024958.9 CASK interacting protein 1, transcript variant 1 (from RefSeq NM_027937.2) CSKI1_MOUSE ENSMUST00000024958.1 ENSMUST00000024958.2 ENSMUST00000024958.3 ENSMUST00000024958.4 ENSMUST00000024958.5 ENSMUST00000024958.6 ENSMUST00000024958.7 ENSMUST00000024958.8 Kiaa1306 NM_027937 Q6P9K8 Q6ZPU2 Q8BWU2 Q8BX99 Q9CXH0 uc008awp.1 uc008awp.2 uc008awp.3 uc008awp.4 uc008awp.5 May link the scaffolding protein CASK to downstream intracellular effectors. Binds the CaM kinase domain of CASK. Forms a ternary complex with CASK and LIN7A, LIN7B or LIN7C. Competes with APBA1 that forms a similar complex with CASK and LIN7 proteins. The tripartite complex CASKIN1/CASK/LIN7(A/B/C) binds the cytoplasmic tail of NRXN1. Polymerizes, via the tandem SAM domains, to form long, 8 nM wide fibers, upon which other proteins can assemble (By similarity). Q6P9K8; Q80Z38: Shank2; NbExp=2; IntAct=EBI-771526, EBI-770338; Cytoplasm Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6P9K8-1; Sequence=Displayed; Name=2; IsoId=Q6P9K8-2; Sequence=VSP_013123; Name=3; IsoId=Q6P9K8-3; Sequence=VSP_013124; Name=4; IsoId=Q6P9K8-4; Sequence=VSP_013121, VSP_013122; cytoplasm signal transduction membrane protein domain specific binding identical protein binding uc008awp.1 uc008awp.2 uc008awp.3 uc008awp.4 uc008awp.5 
ENSMUST00000024959.10 Cript ENSMUST00000024959.10 cysteine-rich PDZ-binding protein (from RefSeq NM_019936.3) CRIPT_MOUSE ENSMUST00000024959.1 ENSMUST00000024959.2 ENSMUST00000024959.3 ENSMUST00000024959.4 ENSMUST00000024959.5 ENSMUST00000024959.6 ENSMUST00000024959.7 ENSMUST00000024959.8 ENSMUST00000024959.9 NM_019936 O70333 Q99LR6 Q9DBP4 uc008duo.1 uc008duo.2 uc008duo.3 uc008duo.4 As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (By similarity). Component of the minor spliceosome. Within this complex, interacts with RNF113A, as well as with SF3B1/SF3b155, SF3B2/SF3b145 and PHF5A/SF3b14b (By similarity). Interacts with TUBB1. Interacts strongly with the PDZ3 domain of members of the DLG4 family. Associates with microtubules (By similarity). Interacts with DLG4. Cytoplasm Synapse Cell projection, dendritic spine Note=Colocalizes with DLG4 in asymmetric synapses. Belongs to the CRIPT family. fibrillar center nucleus nucleolus cytoplasm microtubule binding postsynaptic density cell junction PDZ domain binding dendrite cytoplasmic microtubule organization protein localization to microtubule cell projection neuronal cell body dendritic spine dendritic shaft macromolecular complex binding establishment of protein localization synapse scaffold protein binding regulation of postsynaptic density protein 95 clustering uc008duo.1 uc008duo.2 uc008duo.3 uc008duo.4 
ENSMUST00000024963.11 Mcfd2 ENSMUST00000024963.11 multiple coagulation factor deficiency 2, transcript variant 2 (from RefSeq NM_139295.3) ENSMUST00000024963.1 ENSMUST00000024963.10 ENSMUST00000024963.2 ENSMUST00000024963.3 ENSMUST00000024963.4 ENSMUST00000024963.5 ENSMUST00000024963.6 ENSMUST00000024963.7 ENSMUST00000024963.8 ENSMUST00000024963.9 MCFD2_MOUSE NM_139295 Q3U9G5 Q8K5B2 Sdnsf uc008dur.1 uc008dur.2 uc008dur.3 uc008dur.4 The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Interacts in a calcium-dependent manner with LMAN1. Endoplasmic reticulum-Golgi intermediate compartment Endoplasmic reticulum Golgi apparatus molecular_function calcium ion binding extracellular region endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus protein transport vesicle-mediated transport carboxylic acid metabolic process metal ion binding negative regulation of cell death uc008dur.1 uc008dur.2 uc008dur.3 uc008dur.4 
ENSMUST00000024967.14 Msh2 ENSMUST00000024967.14 mutS homolog 2 (from RefSeq NM_008628.3) ENSMUST00000024967.1 ENSMUST00000024967.10 ENSMUST00000024967.11 ENSMUST00000024967.12 ENSMUST00000024967.13 ENSMUST00000024967.2 ENSMUST00000024967.3 ENSMUST00000024967.4 ENSMUST00000024967.5 ENSMUST00000024967.6 ENSMUST00000024967.7 ENSMUST00000024967.8 ENSMUST00000024967.9 Msh2 NM_008628 Q3TZI5 Q3TZI5_MOUSE uc008dvb.1 uc008dvb.2 uc008dvb.3 Component of the post-replicative DNA mismatch repair system (MMR). Nucleus Belongs to the DNA mismatch repair MutS family. nucleotide binding magnesium ion binding four-way junction DNA binding DNA binding chromatin binding double-stranded DNA binding single-stranded DNA binding ATP binding nucleus DNA repair mismatch repair postreplication repair cellular response to DNA damage stimulus protein C-terminus binding ATPase activity enzyme binding protein kinase binding mismatched DNA binding guanine/thymine mispair binding dinucleotide insertion or deletion binding single guanine insertion binding single thymine insertion binding dinucleotide repeat insertion binding mismatch repair complex MutSalpha complex MutSbeta complex oxidized purine DNA binding MutLalpha complex binding protein homodimerization activity ADP binding maintenance of DNA repeat elements negative regulation of DNA recombination positive regulation of helicase activity protein localization to chromatin uc008dvb.1 uc008dvb.2 uc008dvb.3 
ENSMUST00000024970.11 Gtf2a1l ENSMUST00000024970.11 general transcription factor IIA, 1-like (from RefSeq NM_023630.2) Alf ENSMUST00000024970.1 ENSMUST00000024970.10 ENSMUST00000024970.2 ENSMUST00000024970.3 ENSMUST00000024970.4 ENSMUST00000024970.5 ENSMUST00000024970.6 ENSMUST00000024970.7 ENSMUST00000024970.8 ENSMUST00000024970.9 Gtf2a1lf NM_023630 Q8R4I4 Q99PM2 Q9DAF4 TF2AY_MOUSE uc008dvt.1 uc008dvt.2 uc008dvt.3 uc008dvt.4 May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. Nucleus. Testis specific. Expressed in pachytene spermatocytes and haploid spermatids. Expressed from 14 days postnatal day. Belongs to the TFIIA subunit 1 family. DNA binding protein binding nucleus transcription factor TFIIA complex cytoplasm transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter cognition uc008dvt.1 uc008dvt.2 uc008dvt.3 uc008dvt.4 
ENSMUST00000024972.7 Meiob ENSMUST00000024972.7 meiosis specific with OB domains (from RefSeq NM_029197.1) E9QLG1 ENSMUST00000024972.1 ENSMUST00000024972.2 ENSMUST00000024972.3 ENSMUST00000024972.4 ENSMUST00000024972.5 ENSMUST00000024972.6 MEIOB_MOUSE Meiob NM_029197 Q9D513 uc012ams.1 uc012ams.2 uc012ams.3 Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro. Component of a multiprotein complex with RPA2 and SPATA22. Interacts with the complex BRME1:HSF2BP:BRCA2 (PubMed:32345962). Cytoplasm Nucleus Chromosome Note=Co- localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22. Sprecifically expressed in early meiotic germ cells: in adult and fetal tissues, detected in fetal ovary, postnatal testis and liver. In the ovary, expression starts at 12.5 dpc, reaches a maximum at 15.5 dpc and decreases to become undetectable in post natal life. In testis, expression starts at 10 days post partum (dpp), reaches a maximum at 20 dpp and is maintained throughout adult life. Detected only during early meiosis prophase I (early 4N-fraction containing leptotene, zygotene and few pachytenes spermatocytes) and not during later stages of meiosis (at protein level). Mice develop and grow normally but show infertility in both sexes. Infertility is due to a meiotic arrest at a zygotene/pachytene-like stage. DNA double strand break repair and homologous chromosome synapsis are impaired in meiocytes. Belongs to the MEIOB family. Sequence=AAI19086.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI19088.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB30034.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; resolution of meiotic recombination intermediates double-strand break repair via homologous recombination DNA binding chromatin binding single-stranded DNA binding nuclease activity exonuclease activity protein binding nucleus chromosome cytoplasm synapsis male meiosis male meiosis I female meiosis I single-stranded DNA 3'-5' exodeoxyribonuclease activity fertilization hydrolase activity meiotic cell cycle nucleic acid phosphodiester bond hydrolysis uc012ams.1 uc012ams.2 uc012ams.3 
ENSMUST00000024974.16 Hagh ENSMUST00000024974.16 hydroxyacyl glutathione hydrolase, transcript variant 12 (from RefSeq NM_001409607.1) A0A0R4J052 A0A0R4J052_MOUSE ENSMUST00000024974.1 ENSMUST00000024974.10 ENSMUST00000024974.11 ENSMUST00000024974.12 ENSMUST00000024974.13 ENSMUST00000024974.14 ENSMUST00000024974.15 ENSMUST00000024974.2 ENSMUST00000024974.3 ENSMUST00000024974.4 ENSMUST00000024974.5 ENSMUST00000024974.6 ENSMUST00000024974.7 ENSMUST00000024974.8 ENSMUST00000024974.9 Hagh NM_001409607 uc012amt.1 uc012amt.2 Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. Reaction=(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+); Xref=Rhea:RHEA:25245, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16004, ChEBI:CHEBI:57474, ChEBI:CHEBI:57925; EC=3.1.2.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25246; Evidence=; Reaction=an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+); Xref=Rhea:RHEA:21864, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57925, ChEBI:CHEBI:58896, ChEBI:CHEBI:71261; EC=3.1.2.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21865; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. Monomer. Cytoplasm Mitochondrion matrix Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. hydroxyacylglutathione hydrolase activity methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione uc012amt.1 uc012amt.2 
ENSMUST00000024978.7 Nme3 ENSMUST00000024978.7 NME/NM23 nucleoside diphosphate kinase 3 (from RefSeq NM_019730.2) ENSMUST00000024978.1 ENSMUST00000024978.2 ENSMUST00000024978.3 ENSMUST00000024978.4 ENSMUST00000024978.5 ENSMUST00000024978.6 NDK3_MOUSE NM_019730 Q9D931 Q9EPA2 Q9WV85 uc008ayz.1 uc008ayz.2 uc008ayz.3 uc008ayz.4 uc008ayz.5 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis (By similarity). Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the NDK family. nucleotide binding nucleoside diphosphate kinase activity ATP binding mitochondrion purine nucleotide metabolic process nucleoside diphosphate phosphorylation GTP biosynthetic process pyrimidine nucleotide metabolic process UTP biosynthetic process CTP biosynthetic process nucleotide metabolic process kinase activity phosphorylation transferase activity metal ion binding uc008ayz.1 uc008ayz.2 uc008ayz.3 uc008ayz.4 uc008ayz.5 
ENSMUST00000024981.9 Jpt2 ENSMUST00000024981.9 Jupiter microtubule associated homolog 2 (from RefSeq NM_198937.2) D17Ertd441e ENSMUST00000024981.1 ENSMUST00000024981.2 ENSMUST00000024981.3 ENSMUST00000024981.4 ENSMUST00000024981.5 ENSMUST00000024981.6 ENSMUST00000024981.7 ENSMUST00000024981.8 Hn1l JUPI2_MOUSE Jpt2 NM_198937 Q6PGH2 uc008azj.1 uc008azj.2 uc008azj.3 Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release. Confers NAADP-sensitivity to the two pore channels (TPCs) complex. Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors. Monomer. Dimer. Interacts with TPCN1. Cytoplasm Nucleus Note=Colocalizes with type 1 ryanodine receptor (RYR1). Belongs to the JUPITER family. nucleus cytoplasm cytosol plasma membrane uc008azj.1 uc008azj.2 uc008azj.3 
ENSMUST00000024983.12 Ift140 ENSMUST00000024983.12 intraflagellar transport 140, transcript variant 1 (from RefSeq NM_134126.4) B2RSU5 E9PY46 ENSMUST00000024983.1 ENSMUST00000024983.10 ENSMUST00000024983.11 ENSMUST00000024983.2 ENSMUST00000024983.3 ENSMUST00000024983.4 ENSMUST00000024983.5 ENSMUST00000024983.6 ENSMUST00000024983.7 ENSMUST00000024983.8 ENSMUST00000024983.9 IF140_MOUSE Ift140 NM_134126 Q2XQY6 WDTC2 uc008azm.1 uc008azm.2 uc008azm.3 uc008azm.4 uc008azm.5 Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs) (By similarity). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance (PubMed:22282595). Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (PubMed:24619649). Component of the IFT complex A (IFT-A). IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B. Interacts (via C-terminal region) with IFT122 (via C-terminal region). Interacts with TTC25. Interacts with TTC21A. Cytoplasm, cytoskeleton, cilium basal body toplasm, cytoskeleton, microtubule organizing center, centrosome Cell projection, cilium Note=Defects in Ift140 are the cause of cauliflower (cauli) phenotype, a mouse model for human asphyxiating thoracic dystrophy (Jeune syndrome). Embryos die at 13.5 dpc and exhibit exencephaly, anophthalmia, severely disorganized ribs with extensive exostoses, vertebral and palatal defects, agenesis/hypoplasia of the craniofacial skeleton, and polydactyly of the hindlimbs. Cilia morphology in limb buds is severely disrupted with a broader and bulbous appearance. Mice exhibit pronounced postnatal renal cyst formation and renal failure. Significant increases in expression of canonical Wnt pathway genes and mediators of Hedgehog and tissue fibrosis seen in highly cystic, but not precystic kidneys. Disrupted cilia assembly in postnatal day 5 (P5) kidneys (PubMed:22282595). Mice exhibit cone cell degeneration and opsin accumulation in the plasma membrane of the inner segments of photoreceptor cells (PubMed:24619649). photoreceptor outer segment molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton cilium axoneme determination of left/right symmetry heart development regulation of smoothened signaling pathway neural tube patterning cell projection organization intraciliary transport particle A embryonic camera-type eye development photoreceptor connecting cilium limb morphogenesis intraciliary retrograde transport photoreceptor cell outer segment organization ciliary basal body intraciliary transport embryonic digit morphogenesis cell projection embryonic cranial skeleton morphogenesis skeletal system morphogenesis retina development in camera-type eye cilium assembly protein localization to cilium renal system development non-motile cilium regulation of cilium assembly non-motile cilium assembly embryonic brain development uc008azm.1 uc008azm.2 uc008azm.3 uc008azm.4 uc008azm.5 
ENSMUST00000024984.7 Tmem204 ENSMUST00000024984.7 transmembrane protein 204 (from RefSeq NM_001001183.1) Clp24 ENSMUST00000024984.1 ENSMUST00000024984.2 ENSMUST00000024984.3 ENSMUST00000024984.4 ENSMUST00000024984.5 ENSMUST00000024984.6 NM_001001183 Q7TQI0 TM204_MOUSE uc008azp.1 uc008azp.2 uc008azp.3 Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens (By similarity). Cell junction, adherens junction. Cell membrane ; Multi-pass membrane protein Note=Co- localizes with the beta-catenin adherins. lymph vessel development protein binding plasma membrane adherens junction membrane integral component of membrane cell junction regulation of vascular endothelial growth factor receptor signaling pathway smooth muscle cell differentiation uc008azp.1 uc008azp.2 uc008azp.3 
ENSMUST00000024988.15 C3 ENSMUST00000024988.15 complement component 3 (from RefSeq NM_009778.3) CO3_MOUSE ENSMUST00000024988.1 ENSMUST00000024988.10 ENSMUST00000024988.11 ENSMUST00000024988.12 ENSMUST00000024988.13 ENSMUST00000024988.14 ENSMUST00000024988.2 ENSMUST00000024988.3 ENSMUST00000024988.4 ENSMUST00000024988.5 ENSMUST00000024988.6 ENSMUST00000024988.7 ENSMUST00000024988.8 ENSMUST00000024988.9 NM_009778 P01027 Q61370 Q80XP1 uc008deg.1 uc008deg.2 uc008deg.3 uc008deg.4 This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the complement system. The encoded preproprotein undergoes a multi-step processing to generate various functional peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon infection, display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy, and develop severe lung injury after deposition of IgG immune complexes. Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections, age-related macular degeneration, and atypical hemolytic uremic syndrome. [provided by RefSeq, Mar 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: K02782.1, BC043338.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. The short isoform has B-cell stimulatory activity. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. [Acylation stimulating protein]: Adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2. C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). Forms the pro-C3-convertase enzyme complex by interacting with Complement factor B Bb fragment (Bb), which is then stabilized by binding CFP, allowing the complex to become active (By similarity). The interaction with Bb is dependent on Mg2+ (By similarity). C3b interacts with CR1 (via Sushi 8 and Sushi 9 domains). C3b interacts with CFH. C3d interacts with CFH. C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with VSIG4. Interacts with S.aureus immunoglobulin-binding protein sbi, this prevents interaction between C3dg and CR2. Interacts with S.aureus fib. Interacts (both C3a and ASP) with C5AR2; the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of C5AR2, recruitment of ARRB2 to the cell surface and endocytosis of GRP77. Secreted. Event=Alternative initiation; Named isoforms=2; Name=Long; IsoId=P01027-1; Sequence=Displayed; Name=Short; IsoId=P01027-2; Sequence=VSP_018708; C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxypeptidases to release the C-terminal arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by dietary chylomicrons. Phosphorylated by FAM20C in the extracellular medium. Null mice displayed altered lipid metabolism and morphological changes in adipocyte distribution. There is reduced adipsin/CFD expression, increased number of smaller fat cells, decreased DGAT1 expression and activity, and less triglyceride storage capacity associated with delayed postprandial clearance. Mice on a high-fat diet exihibited no diet-induced up-regulation of adipsin/CFD expression nor adipocyte differentiation. positive regulation of type IIa hypersensitivity positive regulation of protein phosphorylation positive regulation of activation of membrane attack complex immune system process endopeptidase inhibitor activity protein binding extracellular region extracellular space lipid metabolic process fatty acid metabolic process inflammatory response complement activation complement activation, alternative pathway complement activation, classical pathway blood coagulation lipid binding response to bacterium cell surface positive regulation of vascular endothelial growth factor production positive regulation of glucose transport regulation of triglyceride biosynthetic process positive regulation of lipid storage negative regulation of endopeptidase activity neuron remodeling C5L2 anaphylatoxin chemotactic receptor binding macromolecular complex innate immune response positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of angiogenesis cofactor binding positive regulation of receptor-mediated endocytosis positive regulation of developmental growth positive regulation of phagocytosis positive regulation of phagocytosis, engulfment positive regulation of ERK1 and ERK2 cascade beta-amyloid clearance complement-dependent cytotoxicity cell surface receptor signaling pathway involved in cell-cell signaling positive regulation of apoptotic cell clearance uc008deg.1 uc008deg.2 uc008deg.3 uc008deg.4 
ENSMUST00000024993.10 Prss29 ENSMUST00000024993.10 serine protease 29 (from RefSeq NM_053260.3) E9QLD5 E9QLD5_MOUSE ENSMUST00000024993.1 ENSMUST00000024993.2 ENSMUST00000024993.3 ENSMUST00000024993.4 ENSMUST00000024993.5 ENSMUST00000024993.6 ENSMUST00000024993.7 ENSMUST00000024993.8 ENSMUST00000024993.9 NM_053260 Prss29 uc008bap.1 uc008bap.2 uc008bap.3 uc008bap.4 serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc008bap.1 uc008bap.2 uc008bap.3 uc008bap.4 
ENSMUST00000024999.16 Tpsg1 ENSMUST00000024999.16 tryptase gamma 1, transcript variant 1 (from RefSeq NM_012034.4) E9QLD4 E9QLD4_MOUSE ENSMUST00000024999.1 ENSMUST00000024999.10 ENSMUST00000024999.11 ENSMUST00000024999.12 ENSMUST00000024999.13 ENSMUST00000024999.14 ENSMUST00000024999.15 ENSMUST00000024999.2 ENSMUST00000024999.3 ENSMUST00000024999.4 ENSMUST00000024999.5 ENSMUST00000024999.6 ENSMUST00000024999.7 ENSMUST00000024999.8 ENSMUST00000024999.9 NM_012034 Tpsg1 uc008bau.1 uc008bau.2 uc008bau.3 uc008bau.4 uc008bau.5 serine-type endopeptidase activity proteolysis membrane integral component of membrane uc008bau.1 uc008bau.2 uc008bau.3 uc008bau.4 uc008bau.5 
ENSMUST00000025000.4 St6gal2 ENSMUST00000025000.4 beta galactoside alpha 2,6 sialyltransferase 2 (from RefSeq NM_001347403.1) A9C434 ENSMUST00000025000.1 ENSMUST00000025000.2 ENSMUST00000025000.3 Kiaa1877 NM_001347403 Q6ZPG5 Q76K27 Q8BUU4 SIAT2_MOUSE uc057kyc.1 uc057kyc.2 uc057kyc.3 Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6- sialyltransferase activity toward oligosaccharides that have the Gal- beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids. Reaction=a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N- acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+); Xref=Rhea:RHEA:52104, ChEBI:CHEBI:15378, ChEBI:CHEBI:28034, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:136398; EC=2.4.3.1; Evidence=; Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q76K27-1; Sequence=Displayed; Name=2; IsoId=Q76K27-2; Sequence=VSP_030357, VSP_030358; Mainly expressed in brain and embryo. Very low expression is also detected in spleen, oviduct, lung and skeletal muscle. Belongs to the glycosyltransferase 29 family. Sequence=BAC98272.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Name=Functional Glycomics Gateway - GTase; Note=ST6Gal II; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_649"; catalytic activity beta-galactoside alpha-2,6-sialyltransferase activity Golgi apparatus carbohydrate metabolic process N-acetylneuraminate metabolic process protein glycosylation sialyltransferase activity oligosaccharide metabolic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups Golgi cisterna membrane sialylation uc057kyc.1 uc057kyc.2 uc057kyc.3 
ENSMUST00000025002.4 Tekt4 ENSMUST00000025002.4 tektin 4, transcript variant 1 (from RefSeq NM_027951.2) A0A0R4J051 ENSMUST00000025002.1 ENSMUST00000025002.2 ENSMUST00000025002.3 NM_027951 Q149S1 Q3ZTL6 Q9DAH3 TEKT4_MOUSE uc008baw.1 uc008baw.2 uc008baw.3 uc008baw.4 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Contributes to normal sperm motility (PubMed:17244819). Interacts with TEKT3. Cytoplasm, cytoskeleton, cilium axoneme Cell projection, cilium, flagellum Note=Found in the abaxial (convex) surface of outer dense fibers in sperm flagella. Detected in testis, where it is weakly expressed in round spermatids, and strongly expressed in the flagellum of step 16 elongated spermatids (at protein level) (PubMed:17244819). Expressed in spermatozoa (PubMed:36708031). In the sperm flagellum, localizes to the principal piece and midpiece (at protein level) (PubMed:17244819, PubMed:16596631). Specifically expressed in testis; not detected in other tissues tested (PubMed:17244819). Detected in testis from postnatal day 16 onwards, reaching maximal levels by postnatal day 18. In a 129S5/SvEvBrd genetic background, males show progressive reduction in fertility with almost complete loss of fertility after 5 months of breeding. Testis weight and histology appear normal. Spermatozoa have significantly reduced forward motility. The sperm flagellum shows defective bending in the midpiece region which impairs waveform propagation and forward propulsion. Sperm ATP levels deplete significantly over time, probably as a result of excess energy consumption from inefficient flagellar beating. The ultrastructure of the flagellum has some subtle abnormalities with an enlarged space between the mitochondrial sheath and the outer dense fibers. In a mixed C57BL/6J;129S5/SvEvBrd genetic background, male fertility is not significantly affected. Belongs to the tektin family. molecular_function cilium microtubule cytoskeleton cell projection organization motile cilium sperm flagellum cell projection cilium assembly cilium movement involved in cell motility regulation of brood size sperm midpiece sperm principal piece uc008baw.1 uc008baw.2 uc008baw.3 uc008baw.4 
ENSMUST00000025003.11 Sox8 ENSMUST00000025003.11 SRY (sex determining region Y)-box 8 (from RefSeq NM_011447.3) ENSMUST00000025003.1 ENSMUST00000025003.10 ENSMUST00000025003.2 ENSMUST00000025003.3 ENSMUST00000025003.4 ENSMUST00000025003.5 ENSMUST00000025003.6 ENSMUST00000025003.7 ENSMUST00000025003.8 ENSMUST00000025003.9 NM_011447 Q543C3 Q543C3_MOUSE Sox8 uc008bay.1 uc008bay.2 uc008bay.3 uc008bay.4 Nucleus RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding nucleus regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc008bay.1 uc008bay.2 uc008bay.3 uc008bay.4 
ENSMUST00000025004.7 Adgre4 ENSMUST00000025004.7 adhesion G protein-coupled receptor E4 (from RefSeq NM_139138.3) AGRE4_MOUSE ENSMUST00000025004.1 ENSMUST00000025004.2 ENSMUST00000025004.3 ENSMUST00000025004.4 ENSMUST00000025004.5 ENSMUST00000025004.6 Emr4 NM_139138 Q3U1I7 Q8BYX0 Q8VIM3 Q91ZE5 uc008dae.1 uc008dae.2 uc008dae.3 May mediate the cellular interaction between myeloid cells and B-cells. Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Cell membrane ; Multi-pass membrane protein. Predominantly expressed in myeloid cells. Predominantly expressed on resident macrophages. Up-regulated following macrophage activation. The second EGF domain mediates the interaction with the putative ligand. Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit. Glycosylated. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Sequence=AAL31879.1; Type=Erroneous initiation; Evidence=; transmembrane signaling receptor activity G-protein coupled receptor activity calcium ion binding plasma membrane integral component of plasma membrane signal transduction cell surface receptor signaling pathway epidermal growth factor receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway cell surface membrane integral component of membrane uc008dae.1 uc008dae.2 uc008dae.3 
ENSMUST00000025007.7 Nme4 ENSMUST00000025007.7 NME/NM23 nucleoside diphosphate kinase 4 (from RefSeq NM_019731.1) ENSMUST00000025007.1 ENSMUST00000025007.2 ENSMUST00000025007.3 ENSMUST00000025007.4 ENSMUST00000025007.5 ENSMUST00000025007.6 NDKM_MOUSE NM_019731 Q9WV84 uc008bdh.1 uc008bdh.2 uc008bdh.3 uc008bdh.4 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis. Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity. Acts as a mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration. Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria. In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (By similarity). Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Homohexamer (By similarity). Interacts with OPA1 (By similarity). Interacts with CAPN8 (PubMed:16476741). Mitochondrion intermembrane space ; Peripheral membrane protein. Mitochondrion matrix Note=Predominantly localized in the mitochondrion intermembrane space. Colocalizes with OPA1 in mitochondria (By similarity). Expressed in the base region of the oxyntic and pyloric mucosae. Belongs to the NDK family. nucleotide binding nucleoside diphosphate kinase activity ATP binding mitochondrion mitochondrial intermembrane space mitochondrial matrix purine nucleotide metabolic process nucleoside diphosphate phosphorylation GTP biosynthetic process pyrimidine nucleotide metabolic process UTP biosynthetic process CTP biosynthetic process lipid transport lipid binding nucleotide metabolic process membrane kinase activity phosphorylation transferase activity macromolecular complex binding metal ion binding GTPase binding cardiolipin binding uc008bdh.1 uc008bdh.2 uc008bdh.3 uc008bdh.4 
ENSMUST00000025010.14 Pgap6 ENSMUST00000025010.14 post-glycosylphosphatidylinositol attachment to proteins 6 (from RefSeq NM_021793.2) ENSMUST00000025010.1 ENSMUST00000025010.10 ENSMUST00000025010.11 ENSMUST00000025010.12 ENSMUST00000025010.13 ENSMUST00000025010.2 ENSMUST00000025010.3 ENSMUST00000025010.4 ENSMUST00000025010.5 ENSMUST00000025010.6 ENSMUST00000025010.7 ENSMUST00000025010.8 ENSMUST00000025010.9 NM_021793 PGAP6_MOUSE Pgap6 Q543X8 Q99JS5 Q9ESN3 Tmem8 Tmem8a uc008bdj.1 uc008bdj.2 uc008bdj.3 uc008bdj.4 Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1- enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane. Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; Cell membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=Alpha; IsoId=Q9ESN3-1; Sequence=Displayed; Name=Beta; IsoId=Q9ESN3-2; Sequence=VSP_004005; Glycosylated. Embryonic lethal with anterior-posterior axis formation defects in embryos from 6.7 dpc on until cessation of development at latest in 10 dpc. Belongs to the TMEM8 family. molecular_function phospholipase A2 activity lysosome lysosomal membrane plasma membrane integral component of plasma membrane biological_process membrane integral component of membrane hydrolase activity uc008bdj.1 uc008bdj.2 uc008bdj.3 uc008bdj.4 
ENSMUST00000025014.10 Mrpl28 ENSMUST00000025014.10 mitochondrial ribosomal protein L28 (from RefSeq NM_024227.3) A6H5Y0 ENSMUST00000025014.1 ENSMUST00000025014.2 ENSMUST00000025014.3 ENSMUST00000025014.4 ENSMUST00000025014.5 ENSMUST00000025014.6 ENSMUST00000025014.7 ENSMUST00000025014.8 ENSMUST00000025014.9 NM_024227 Q3TR04 Q497Y8 Q66JU7 Q9D1B9 RM28_MOUSE uc008bdl.1 uc008bdl.2 uc008bdl.3 uc008bdl.4 uc008bdl.5 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: BC005797.1, AK163190.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with OXA1L. Mitochondrion Belongs to the bacterial ribosomal protein bL28 family. Sequence=AAH02293.2; Type=Erroneous initiation; Evidence=; Sequence=AAH05797.2; Type=Erroneous initiation; Evidence=; Sequence=AAH80753.1; Type=Erroneous initiation; Evidence=; Sequence=AAI00323.1; Type=Erroneous initiation; Evidence=; Sequence=BAB22962.2; Type=Erroneous initiation; Evidence=; Sequence=BAC27521.1; Type=Erroneous initiation; Evidence=; Sequence=BAC32780.1; Type=Erroneous initiation; Evidence=; structural constituent of ribosome mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit cytosol ribosome biological_process uc008bdl.1 uc008bdl.2 uc008bdl.3 uc008bdl.4 uc008bdl.5 
ENSMUST00000025019.9 Arhgdig ENSMUST00000025019.9 Rho GDP dissociation inhibitor gamma (from RefSeq NM_008113.3) ENSMUST00000025019.1 ENSMUST00000025019.2 ENSMUST00000025019.3 ENSMUST00000025019.4 ENSMUST00000025019.5 ENSMUST00000025019.6 ENSMUST00000025019.7 ENSMUST00000025019.8 GDIR3_MOUSE Gdi5 NM_008113 Q62160 uc008bdp.1 uc008bdp.2 Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP. Cytoplasm Detected only in brain, lung, kidney and testis. Belongs to the Rho GDI family. blastocyst hatching GDP-dissociation inhibitor activity Rho GDP-dissociation inhibitor activity GTPase activator activity protein binding cytoplasm cytosol plasma membrane Rho protein signal transduction membrane GTPase regulator activity regulation of protein localization positive regulation of GTPase activity Rac GTPase binding regulation of catalytic activity uc008bdp.1 uc008bdp.2 
ENSMUST00000025020.6 Rgs11 ENSMUST00000025020.6 regulator of G-protein signaling 11 (from RefSeq NM_001081069.3) ENSMUST00000025020.1 ENSMUST00000025020.2 ENSMUST00000025020.3 ENSMUST00000025020.4 ENSMUST00000025020.5 G3X8W6 G3X8W6_MOUSE NM_001081069 Rgs11 uc008bdr.1 uc008bdr.2 G-protein coupled receptor signaling pathway G-protein beta-subunit binding macromolecular complex intracellular signal transduction uc008bdr.1 uc008bdr.2 
ENSMUST00000025025.7 Dusp1 ENSMUST00000025025.7 dual specificity phosphatase 1 (from RefSeq NM_013642.3) Dusp1 ENSMUST00000025025.1 ENSMUST00000025025.2 ENSMUST00000025025.3 ENSMUST00000025025.4 ENSMUST00000025025.5 ENSMUST00000025025.6 NM_013642 Q3U8K3 Q3U8K3_MOUSE uc008bee.1 uc008bee.2 uc008bee.3 uc008bee.4 Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Nucleus Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. inactivation of MAPK activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm protein dephosphorylation negative regulation of cell adhesion protein tyrosine/serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity response to light stimulus response to organic substance dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity growth factor binding response to estradiol response to retinoic acid cellular response to hormone stimulus response to testosterone peptidyl-tyrosine dephosphorylation intracellular signal transduction response to hydrogen peroxide positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of MAP kinase activity response to glucocorticoid response to cAMP response to calcium ion negative regulation of ERK1 and ERK2 cascade negative regulation of monocyte chemotaxis negative regulation of p38MAPK cascade cellular response to chemokine negative regulation of DNA biosynthetic process uc008bee.1 uc008bee.2 uc008bee.3 uc008bee.4 
ENSMUST00000025036.11 Kdm4b ENSMUST00000025036.11 lysine (K)-specific demethylase 4B, transcript variant 1 (from RefSeq NM_172132.3) ENSMUST00000025036.1 ENSMUST00000025036.10 ENSMUST00000025036.2 ENSMUST00000025036.3 ENSMUST00000025036.4 ENSMUST00000025036.5 ENSMUST00000025036.6 ENSMUST00000025036.7 ENSMUST00000025036.8 ENSMUST00000025036.9 Jhdm3b Jmjd2b KDM4B_MOUSE NM_172132 Q3UR22 Q6ZQ30 Q91VY5 Q99K42 uc008dbv.1 uc008dbv.2 uc008dbv.3 uc008dbv.4 Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys- 20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). Plays a critical role in the development of the central nervous system (CNS). Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)- [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60200, Rhea:RHEA- COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961; EC=1.14.11.66; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VY5-1; Sequence=Displayed; Name=2; IsoId=Q91VY5-2; Sequence=VSP_018309, VSP_018310; Expression is especially strong in the hippocampus and throughout the CNS from embryonic periods through adulthood. The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity). Belongs to the JHDM3 histone demethylase family. Sequence=BAC98043.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleus cytosol chromatin organization chromatin remodeling oxidoreductase activity nuclear pericentric heterochromatin histone demethylase activity histone demethylase activity (H3-K9 specific) histone H3-K9 demethylation histone methyltransferase complex metal ion binding dioxygenase activity histone demethylase activity (H3-K36 specific) oxidation-reduction process histone H3-K36 demethylation negative regulation of histone H3-K9 trimethylation uc008dbv.1 uc008dbv.2 uc008dbv.3 uc008dbv.4 
ENSMUST00000025045.15 Uqcc2 ENSMUST00000025045.15 ubiquinol-cytochrome c reductase complex assembly factor 2, transcript variant 1 (from RefSeq NM_026063.2) ENSMUST00000025045.1 ENSMUST00000025045.10 ENSMUST00000025045.11 ENSMUST00000025045.12 ENSMUST00000025045.13 ENSMUST00000025045.14 ENSMUST00000025045.2 ENSMUST00000025045.3 ENSMUST00000025045.4 ENSMUST00000025045.5 ENSMUST00000025045.6 ENSMUST00000025045.7 ENSMUST00000025045.8 ENSMUST00000025045.9 Mnf1 NM_026063 Q9CQY6 UQCC2_MOUSE uc008bfk.1 uc008bfk.2 uc008bfk.3 Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability. Interacts with UQCC1 (By similarity). Forms a complex, named COMB/coordinator of mitochondrial CYTB biogenesis, composed of UQCC1, UQCC2, UQCC4, UQCC5 and UQCC6; stabilizes nascent cytochrome b/MT-CYB and promotes its membrane insertion (PubMed:35977508). Forms a complex, named COMA, composed of UQCC1, UQCC2 and UQCC4; activates MT-CYB translation (PubMed:35977508). Forms a complex, named COMC, composed of UQCC1, UQCC2; UQCC3 and UQCC4; mediates MT-CYB hemylation and association with the first nuclear-encoded CIII subunit UQCRQ (PubMed:35977508). Mitochondrion matrix, mitochondrion nucleoid Mitochondrion Mitochondrion intermembrane space Mitochondrion matrix Mitochondrion inner membrane Note=Predominantly expressed in the mitochondrial inner membrane. Widely expressed with highest levels in brain, liver, kidney, heart, skeletal muscle, thymus, testis and pancreas (at protein level). regulation of oxidative phosphorylation molecular_function mitochondrion mitochondrial inner membrane mitochondrial intermembrane space mitochondrial matrix membrane nuclear body mitochondrial respiratory chain complex III assembly mitochondrial nucleoid regulation of insulin secretion positive regulation of mitochondrial translation positive regulation of cellular protein catabolic process regulation of skeletal muscle cell differentiation uc008bfk.1 uc008bfk.2 uc008bfk.3 
ENSMUST00000025046.4 Ip6k3 ENSMUST00000025046.4 inositol hexaphosphate kinase 3 (from RefSeq NM_173027.2) ENSMUST00000025046.1 ENSMUST00000025046.2 ENSMUST00000025046.3 IP6K3_MOUSE Ihpk3 NM_173027 Q8BWD2 uc008bfl.1 uc008bfl.2 uc008bfl.3 uc008bfl.4 Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity). Reaction=1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo- inositol 1,2,3,4,6-pentakisphosphate + ADP; Xref=Rhea:RHEA:12793, ChEBI:CHEBI:30616, ChEBI:CHEBI:58130, ChEBI:CHEBI:58628, ChEBI:CHEBI:456216; EC=2.7.4.21; Reaction=1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP; Xref=Rhea:RHEA:37467, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:74946, ChEBI:CHEBI:77983, ChEBI:CHEBI:456216; EC=2.7.4.21; Cytoplasm Highly expressed in cerebellum, brain cortex, kidney, thymus and lung. Detected at lower levels in hippocampus, testis, heart and olfactory bulb. Belongs to the inositol phosphokinase (IPK) family. nucleotide binding inositol hexakisphosphate kinase activity inositol hexakisphosphate 6-kinase activity inositol hexakisphosphate 5-kinase activity ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity inositol phosphate biosynthetic process phosphatidylinositol metabolic process inositol hexakisphosphate 1-kinase activity inositol hexakisphosphate 3-kinase activity uc008bfl.1 uc008bfl.2 uc008bfl.3 uc008bfl.4 
ENSMUST00000025048.7 Acsbg3 ENSMUST00000025048.7 acyl-CoA synthetase bubblegum family member 3 (from RefSeq NM_030141.2) 1700061G19Rik Acsbg3 ENSMUST00000025048.1 ENSMUST00000025048.2 ENSMUST00000025048.3 ENSMUST00000025048.4 ENSMUST00000025048.5 ENSMUST00000025048.6 NM_030141 Q08EE8 Q08EE8_MOUSE uc008ddj.1 uc008ddj.2 uc008ddj.3 molecular_function catalytic activity cellular_component biological_process uc008ddj.1 uc008ddj.2 uc008ddj.3 
ENSMUST00000025050.13 Nudt3 ENSMUST00000025050.13 nudix hydrolase 3, transcript variant 1 (from RefSeq NM_019837.2) B2KF68 Dipp Dipp1 ENSMUST00000025050.1 ENSMUST00000025050.10 ENSMUST00000025050.11 ENSMUST00000025050.12 ENSMUST00000025050.2 ENSMUST00000025050.3 ENSMUST00000025050.4 ENSMUST00000025050.5 ENSMUST00000025050.6 ENSMUST00000025050.7 ENSMUST00000025050.8 ENSMUST00000025050.9 NM_019837 NUDT3_MOUSE Nudt3 Q6PG02 Q8BV71 Q9JI46 uc008bpg.1 uc008bpg.2 uc008bpg.3 uc008bpg.4 Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:15212765). InsP6 (inositol hexakisphosphate) is not a substrate (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates (By similarity). The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A (By similarity). Also able to hydrolyze 5- phosphoribose 1-diphosphate (By similarity). Acts as a negative regulator of the ERK1/2 pathway (PubMed:15212765). Acts as a decapping enzyme that can hydrolyze both monomethylated and unmethylated capped RNAs (PubMed:23353937). Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA (PubMed:23353937). Modulates the stability of a subset of mRNAs implicated in cell motility (By similarity). Divalent cations zinc, magnesium and manganese determine its substrate specificity (By similarity). Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions, diadenosine hexaphosphate hydrolase activity in the presence of manganese ions and endopolyphosphatase activity in the presence of zinc ions (By similarity). Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity (By similarity). Reaction=diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.; EC=3.6.1.52; Evidence=; Reaction=5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + H(+) + phosphate; Xref=Rhea:RHEA:22384, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58130, ChEBI:CHEBI:58628; EC=3.6.1.52; Evidence=; Reaction=3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate; Xref=Rhea:RHEA:56312, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:140372, ChEBI:CHEBI:140374; EC=3.6.1.52; Evidence=; Reaction=[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate; Xref=Rhea:RHEA:22452, Rhea:RHEA-COMP:14280, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16838, ChEBI:CHEBI:43474; EC=3.6.1.10; Evidence=; Reaction=H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = ADP + ATP + 2 H(+); Xref=Rhea:RHEA:30527, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:62041, ChEBI:CHEBI:456216; EC=3.6.1.61; Evidence=; Reaction=H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = 2 ATP + 2 H(+); Xref=Rhea:RHEA:32043, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:63740; EC=3.6.1.61; Evidence=; Reaction=H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = AMP + ATP + 2 H(+); Xref=Rhea:RHEA:32039, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58141, ChEBI:CHEBI:456215; EC=3.6.1.61; Evidence=; Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP; Xref=Rhea:RHEA:65388, Rhea:RHEA-COMP:17165, Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58285, ChEBI:CHEBI:156461, ChEBI:CHEBI:167616; EC=3.6.1.59; Evidence=; Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP; Xref=Rhea:RHEA:67484, Rhea:RHEA-COMP:15692, Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:63714, ChEBI:CHEBI:138282, ChEBI:CHEBI:156461; EC=3.6.1.62; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Mg(2+) ions per subunit. ; Monomer. Cytoplasm Nucleus Present in heart, lung, liver and spleen (at protein level). Widely expressed. Belongs to the Nudix hydrolase family. DIPP subfamily. Sequence=AAH57331.1; Type=Miscellaneous discrepancy; Note=Chimeric at the C-terminus.; Evidence=; magnesium ion binding endopolyphosphatase activity nucleus cytoplasm cytosol diphosphoinositol-polyphosphate diphosphatase activity hydrolase activity bis(5'-adenosyl)-hexaphosphatase activity bis(5'-adenosyl)-pentaphosphatase activity metal ion binding m7G(5')pppN diphosphatase activity inositol diphosphate tetrakisphosphate diphosphatase activity inositol diphosphate pentakisphosphate diphosphatase activity diphosphoinositol polyphosphate metabolic process diphosphoinositol polyphosphate catabolic process diadenosine pentaphosphate catabolic process diadenosine hexaphosphate catabolic process adenosine 5'-(hexahydrogen pentaphosphate) catabolic process uc008bpg.1 uc008bpg.2 uc008bpg.3 uc008bpg.4 
ENSMUST00000025053.10 Mllt1 ENSMUST00000025053.10 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1, transcript variant 1 (from RefSeq NM_022328.3) ENSMUST00000025053.1 ENSMUST00000025053.2 ENSMUST00000025053.3 ENSMUST00000025053.4 ENSMUST00000025053.5 ENSMUST00000025053.6 ENSMUST00000025053.7 ENSMUST00000025053.8 ENSMUST00000025053.9 Mllt1 NM_022328 Q9ERL0 Q9ERL0_MOUSE uc008ddk.1 uc008ddk.2 uc008ddk.3 Nucleus fibrillar center protein binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated negative regulation of protein kinase activity transcription elongation factor complex uc008ddk.1 uc008ddk.2 uc008ddk.3 
ENSMUST00000025054.10 Spdef ENSMUST00000025054.10 SAM pointed domain containing ets transcription factor, transcript variant 1 (from RefSeq NM_013891.4) ENSMUST00000025054.1 ENSMUST00000025054.2 ENSMUST00000025054.3 ENSMUST00000025054.4 ENSMUST00000025054.5 ENSMUST00000025054.6 ENSMUST00000025054.7 ENSMUST00000025054.8 ENSMUST00000025054.9 NM_013891 Pdef Pse Q9WTP3 SPDEF_MOUSE uc008bpo.1 uc008bpo.2 uc008bpo.3 uc008bpo.4 May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter (By similarity). Interacts with the DNA-binding domain of the androgen receptor. Interacts with NKX3-1 (By similarity). Nucleus Expressed in the accessory glands of sex organs including the prostate, seminal vesicle, coagulating gland in males, the oviduct in females, and in intestines. Expression is epithelial- specific. Belongs to the ETS family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter negative regulation of cell fate commitment positive regulation of cell fate commitment cell differentiation positive regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter lung goblet cell differentiation intestinal epithelial cell development uc008bpo.1 uc008bpo.2 uc008bpo.3 uc008bpo.4 
ENSMUST00000025061.6 Clpsl2 ENSMUST00000025061.6 colipase-like 2 (from RefSeq NM_001034871.2) COLL2_MOUSE ENSMUST00000025061.1 ENSMUST00000025061.2 ENSMUST00000025061.3 ENSMUST00000025061.4 ENSMUST00000025061.5 Gm749 NM_001034871 Q3UW21 uc008bre.1 uc008bre.2 uc008bre.3 Secreted Belongs to the colipase family. cellular_component extracellular region digestion enzyme activator activity lipid catabolic process response to food positive regulation of catalytic activity uc008bre.1 uc008bre.2 uc008bre.3 
ENSMUST00000025062.5 Clps ENSMUST00000025062.5 colipase, pancreatic, transcript variant 1 (from RefSeq NM_025469.3) COL_MOUSE Clps ENSMUST00000025062.1 ENSMUST00000025062.2 ENSMUST00000025062.3 ENSMUST00000025062.4 NM_025469 Q8VHR2 Q8VHR3 Q9CQC2 uc008brf.1 uc008brf.2 uc008brf.3 uc008brf.4 This gene encodes a member of the colipase family of coenzymes that is required for the optimal activity of pancreatic lipase. The encoded protein undergoes proteolytic processing to generate a mature polypeptide that binds to the lipase and prevents inhibition by bile acids. Over half of the mice lacking the encoded protein die within two weeks of birth while the remaining ones exhibit fat malabsorption and altered body weight regulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]. Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Enterostatin has a biological activity as a satiety signal. Forms a 1:1 stoichiometric complex with pancreatic lipase. Secreted Expressed by the pancreas. Belongs to the colipase family. extracellular region lipid metabolic process digestion enzyme activator activity response to bacterium lipid catabolic process response to food positive regulation of catalytic activity uc008brf.1 uc008brf.2 uc008brf.3 uc008brf.4 
ENSMUST00000025064.14 Pdzph1 ENSMUST00000025064.14 PDZ and pleckstrin homology domains 1 (from RefSeq NM_027001.2) ENSMUST00000025064.1 ENSMUST00000025064.10 ENSMUST00000025064.11 ENSMUST00000025064.12 ENSMUST00000025064.13 ENSMUST00000025064.2 ENSMUST00000025064.3 ENSMUST00000025064.4 ENSMUST00000025064.5 ENSMUST00000025064.6 ENSMUST00000025064.7 ENSMUST00000025064.8 ENSMUST00000025064.9 F6UGR1 F6UGR1_MOUSE NM_027001 Pdzph1 uc008dez.1 uc008dez.2 uc008dez.1 uc008dez.2 
ENSMUST00000025065.12 Nudt12 ENSMUST00000025065.12 nudix hydrolase 12, transcript variant 1 (from RefSeq NM_026497.3) ENSMUST00000025065.1 ENSMUST00000025065.10 ENSMUST00000025065.11 ENSMUST00000025065.2 ENSMUST00000025065.3 ENSMUST00000025065.4 ENSMUST00000025065.5 ENSMUST00000025065.6 ENSMUST00000025065.7 ENSMUST00000025065.8 ENSMUST00000025065.9 NM_026497 NUD12_MOUSE Nudt12 Q6PFA5 Q9DCN1 uc008dfc.1 uc008dfc.2 uc008dfc.3 mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PubMed:31101919, PubMed:32432673). The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:31101919). Preferentially acts on NAD- capped transcripts in response to nutrient stress (PubMed:31101919). Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'- ADP (By similarity). May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity). Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (PubMed:31875550). Reaction=a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'- end phospho-adenosine-phospho-ribonucleoside in mRNA + beta- nicotinamide D-ribonucleotide + 2 H(+); Xref=Rhea:RHEA:60876, Rhea:RHEA-COMP:15698, Rhea:RHEA-COMP:15719, ChEBI:CHEBI:14649, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:144029, ChEBI:CHEBI:144051; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60877; Evidence=; Reaction=H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+); Xref=Rhea:RHEA:11800, ChEBI:CHEBI:14649, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:456215; EC=3.6.1.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11801; Evidence=; Reaction=H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D- ribonucleotide; Xref=Rhea:RHEA:48868, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57945, ChEBI:CHEBI:90832, ChEBI:CHEBI:456215; EC=3.6.1.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48869; Evidence=; Reaction=H2O + NADPH = adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide; Xref=Rhea:RHEA:60820, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:90832, ChEBI:CHEBI:194156; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60821; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 3 Mg(2+) ions per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Homodimer (PubMed:31101919). Homodimerization is essential for its catalytic activity and protein stability (By similarity). Interacts (via ANK repeats) with BLMH (By similarity). Cytoplasm Peroxisome Cytoplasmic granule Note=Localizes to cytoplasmic granules in the presence of BLMH. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DCN1-1; Sequence=Displayed; Name=2; IsoId=Q9DCN1-2; Sequence=VSP_014280, VSP_014281; Expressed abundantly in the liver and kidney. Belongs to the Nudix hydrolase family. NudC subfamily. NAD+ diphosphatase activity nucleus cytoplasm peroxisome cytosol NADH metabolic process NADP catabolic process hydrolase activity NAD catabolic process NADH pyrophosphatase activity metal ion binding uc008dfc.1 uc008dfc.2 uc008dfc.3 
ENSMUST00000025075.3 Bambi ENSMUST00000025075.3 BMP and activin membrane-bound inhibitor (from RefSeq NM_026505.2) BAMBI_MOUSE ENSMUST00000025075.1 ENSMUST00000025075.2 NM_026505 Nma Q3TP85 Q91XS6 Q9D0L6 uc008dyc.1 uc008dyc.2 uc008dyc.3 Negatively regulates TGF-beta signaling. Membrane ; Single-pass type I membrane protein Expressed at high levels during odontogenesis. Belongs to the BAMBI family. frizzled binding cytoplasm plasma membrane transforming growth factor beta receptor signaling pathway positive regulation of cell proliferation regulation of cell shape positive regulation of epithelial to mesenchymal transition membrane integral component of membrane cell migration negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of protein binding positive regulation of transcription, DNA-templated positive regulation of canonical Wnt signaling pathway uc008dyc.1 uc008dyc.2 uc008dyc.3 
ENSMUST00000025076.10 Lyzl1 ENSMUST00000025076.10 lysozyme-like 1, transcript variant 1 (from RefSeq NM_026092.4) ENSMUST00000025076.1 ENSMUST00000025076.2 ENSMUST00000025076.3 ENSMUST00000025076.4 ENSMUST00000025076.5 ENSMUST00000025076.6 ENSMUST00000025076.7 ENSMUST00000025076.8 ENSMUST00000025076.9 LYZL1_MOUSE Lyc2 NM_026092 Q9CPX3 uc008dyd.1 uc008dyd.2 uc008dyd.3 Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17; Monomer. Secreted Belongs to the glycosyl hydrolase 22 family. lysozyme activity extracellular region metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds defense response to Gram-negative bacterium defense response to Gram-positive bacterium uc008dyd.1 uc008dyd.2 uc008dyd.3 
ENSMUST00000025077.7 Mtpap ENSMUST00000025077.7 mitochondrial poly(A) polymerase, transcript variant 1 (from RefSeq NM_026157.4) ENSMUST00000025077.1 ENSMUST00000025077.2 ENSMUST00000025077.3 ENSMUST00000025077.4 ENSMUST00000025077.5 ENSMUST00000025077.6 NM_026157 PAPD1_MOUSE Papd1 Q3UXJ1 Q8C651 Q9D0D3 uc008dyi.1 uc008dyi.2 Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA (By similarity). Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, ChEBI:CHEBI:173115; EC=2.7.7.19; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Homodimer. Cytoplasm Mitochondrion Belongs to the DNA polymerase type-B-like family. nucleotide binding magnesium ion binding UTP binding RNA binding polynucleotide adenylyltransferase activity ATP binding cytoplasm mitochondrion mRNA polyadenylation mRNA processing transferase activity manganese ion binding identical protein binding protein homodimerization activity intracellular membrane-bounded organelle metal ion binding histone mRNA catabolic process uc008dyi.1 uc008dyi.2 
ENSMUST00000025078.10 Map3k8 ENSMUST00000025078.10 mitogen-activated protein kinase kinase kinase 8, transcript variant 1 (from RefSeq NM_007746.2) ENSMUST00000025078.1 ENSMUST00000025078.2 ENSMUST00000025078.3 ENSMUST00000025078.4 ENSMUST00000025078.5 ENSMUST00000025078.6 ENSMUST00000025078.7 ENSMUST00000025078.8 ENSMUST00000025078.9 Map3k8 NM_007746 Q3UEB8 Q3UEB8_MOUSE uc008dye.1 uc008dye.2 uc008dye.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. MAPK cascade activation of MAPKK activity magnesium ion binding protein kinase activity MAP kinase kinase kinase activity ATP binding cytoplasm cytosol protein phosphorylation signal transduction kinase activity phosphorylation uc008dye.1 uc008dye.2 uc008dye.3 
ENSMUST00000025081.13 Zeb1 ENSMUST00000025081.13 zinc finger E-box binding homeobox 1, transcript variant 1 (from RefSeq NM_011546.3) A4QPD2 Areb6 ENSMUST00000025081.1 ENSMUST00000025081.10 ENSMUST00000025081.11 ENSMUST00000025081.12 ENSMUST00000025081.2 ENSMUST00000025081.3 ENSMUST00000025081.4 ENSMUST00000025081.5 ENSMUST00000025081.6 ENSMUST00000025081.7 ENSMUST00000025081.8 ENSMUST00000025081.9 NM_011546 Q62519 Q64318 Tcf8 ZEB1_MOUSE Zeb1 Zfhx1a Zfx1a Zfx1ha uc008dyy.1 uc008dyy.2 uc008dyy.3 uc008dyy.4 Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1 (By similarity). Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'- CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (PubMed:20713358). Promotes tumorigenicity by repressing stemness- inhibiting microRNAs (PubMed:19935649). Interacts (via N-terminus) with SMARCA4/BRG1. Q64318; O88712: Ctbp1; NbExp=5; IntAct=EBI-8560245, EBI-604547; Nucleus Expressed in the external germinal layer (EGL) and internal granular layer (IGL) of the cerebellum (at protein level). Induced during Neurod2-induced neurogenesis. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding chromatin binding double-stranded DNA binding protein binding nucleus nucleoplasm cytosol pattern specification process nervous system development central nervous system development negative regulation of cell proliferation regulation of mesenchymal cell proliferation regulation of transforming growth factor beta receptor signaling pathway cell differentiation negative regulation of epithelial cell differentiation regulation of T cell differentiation in thymus sequence-specific DNA binding negative regulation of endothelial cell differentiation positive regulation of neuron differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding animal organ development embryonic camera-type eye morphogenesis embryonic morphogenesis embryonic skeletal system morphogenesis semicircular canal morphogenesis regulation of smooth muscle cell differentiation cartilage development E-box binding cellular response to amino acid stimulus cochlea morphogenesis uc008dyy.1 uc008dyy.2 uc008dyy.3 uc008dyy.4 
ENSMUST00000025083.14 Kif5b ENSMUST00000025083.14 kinesin family member 5B (from RefSeq NM_008448.3) ENSMUST00000025083.1 ENSMUST00000025083.10 ENSMUST00000025083.11 ENSMUST00000025083.12 ENSMUST00000025083.13 ENSMUST00000025083.2 ENSMUST00000025083.3 ENSMUST00000025083.4 ENSMUST00000025083.5 ENSMUST00000025083.6 ENSMUST00000025083.7 ENSMUST00000025083.8 ENSMUST00000025083.9 KINH_MOUSE Khcs Kns1 NM_008448 O08711 Q5BL10 Q61580 Q61768 uc008dzf.1 uc008dzf.2 uc008dzf.3 uc008dzf.4 Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence (PubMed:9657148). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (PubMed:21976701). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2- dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends. Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity). Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and PPP1R42 (PubMed:11986669, PubMed:19886865). Interacts with SYBU (By similarity). Interacts with JAKMIP1 (PubMed:17532644). Interacts with PLEKHM2. Interacts with ECPAS (By similarity). Interacts with ZFYVE27 (PubMed:21976701). Found in a complex with OGT, RHOT1, RHOT2 and TRAK1 (By similarity). Interacts with APP (via cytoplasmic domain) (By similarity). Q61768; O88485: Dync1i1; NbExp=4; IntAct=EBI-776129, EBI-492834; Q61768; O35685: Nudc; NbExp=4; IntAct=EBI-776129, EBI-911192; Cytoplasm, cytoskeleton Cytolytic granule membrane Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Uniformly distributed between soma and neurites in hippocampal neurons. Composed of three structural domains: a large globular N- terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles. Mice are embryonic lethal. They show perinuclear clustering of mitochondria and impaired lysosomal dispersion. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily. nucleotide binding microtubule motor activity protein binding ATP binding cytoplasm microtubule organizing center cytosol cytoskeleton kinesin complex microtubule mitochondrial transport microtubule-based process microtubule-based movement cytoplasm organization axon guidance brain development microtubule binding JUN kinase binding ATP-dependent microtubule motor activity, plus-end-directed microtubule cytoskeleton ATPase activity hippocampus development endocytic vesicle positive regulation of vesicle fusion vesicle positive regulation of synaptic transmission, GABAergic dendrite cytoplasm ciliary rootlet stress granule disassembly positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of membrane potential identical protein binding neuron projection membrane-bounded organelle positive regulation of potassium ion transport axonal growth cone phagocytic vesicle vesicle transport along microtubule perinuclear region of cytoplasm synaptic vesicle transport centrosome localization cellular response to interferon-gamma plus-end-directed vesicle transport along microtubule positive regulation of intracellular protein transport anterograde dendritic transport of neurotransmitter receptor complex microtubule lateral binding anterograde axonal protein transport positive regulation of protein localization to plasma membrane axon cytoplasm positive regulation of voltage-gated sodium channel activity retrograde neuronal dense core vesicle transport uc008dzf.1 uc008dzf.2 uc008dzf.3 uc008dzf.4 
ENSMUST00000025089.9 Map4k3 ENSMUST00000025089.9 mitogen-activated protein kinase kinase kinase kinase 3, transcript variant 1 (from RefSeq NM_001290345.1) E9PWI4 ENSMUST00000025089.1 ENSMUST00000025089.2 ENSMUST00000025089.3 ENSMUST00000025089.4 ENSMUST00000025089.5 ENSMUST00000025089.6 ENSMUST00000025089.7 ENSMUST00000025089.8 M4K3_MOUSE NM_001290345 Q99JP0 Q9CUS8 uc008drk.1 uc008drk.2 uc008drk.3 uc008drk.4 May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with SH3GL2. Interaction appears to regulate MAP4K3- mediated JNK activation (By similarity). Q99JP0; Q02111: Prkcq; NbExp=2; IntAct=EBI-5324222, EBI-2639157; Q99JP0; Q13094: LCP2; Xeno; NbExp=2; IntAct=EBI-5324222, EBI-346946; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. MAPK cascade nucleotide binding activation of MAPKKK activity protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm protein phosphorylation MAP kinase kinase kinase kinase activity response to UV kinase activity phosphorylation transferase activity SH3 domain binding signal transduction by protein phosphorylation activation of protein kinase activity response to tumor necrosis factor intracellular signal transduction uc008drk.1 uc008drk.2 uc008drk.3 uc008drk.4 
ENSMUST00000025092.5 Tmem178 ENSMUST00000025092.5 transmembrane protein 178 (from RefSeq NM_026516.2) ENSMUST00000025092.1 ENSMUST00000025092.2 ENSMUST00000025092.3 ENSMUST00000025092.4 F8VPV2 NM_026516 Q8CEU4 Q9CZ16 T178A_MOUSE Tmem178a uc008drn.1 uc008drn.2 Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1 (PubMed:26644563). Interacts with STIM1. Endoplasmic reticulum membrane ; Multi-pass membrane protein Highly expressed in the bone and its expression increases during osteoclastogenesis. Mice are osteopenic and are more susceptible to inflammatory bone loss, owing to enhanced osteoclast formation. Belongs to the TMEM178 family. Sequence=BAB28655.1; Type=Frameshift; Evidence=; Sequence=BAC25428.1; Type=Frameshift; Evidence=; protein binding endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane negative regulation of osteoclast differentiation regulation of cytosolic calcium ion concentration uc008drn.1 uc008drn.2 
ENSMUST00000025093.6 Thumpd2 ENSMUST00000025093.6 THUMP domain containing 2 (from RefSeq NM_028138.1) ENSMUST00000025093.1 ENSMUST00000025093.2 ENSMUST00000025093.3 ENSMUST00000025093.4 ENSMUST00000025093.5 NM_028138 Q9CZB3 THUM2_MOUSE uc008drp.1 uc008drp.2 uc008drp.3 uc008drp.4 Interacts with TRMT112. Belongs to the methyltransferase superfamily. RNA binding cellular_component methyltransferase activity tRNA (guanine) methyltransferase activity transferase activity tRNA methylation methylation uc008drp.1 uc008drp.2 uc008drp.3 uc008drp.4 
ENSMUST00000025095.9 Cox7a2l ENSMUST00000025095.9 cytochrome c oxidase subunit 7A2 like, transcript variant 2 (from RefSeq NM_009187.3) COX7R_MOUSE Cox7rp ENSMUST00000025095.1 ENSMUST00000025095.2 ENSMUST00000025095.3 ENSMUST00000025095.4 ENSMUST00000025095.5 ENSMUST00000025095.6 ENSMUST00000025095.7 ENSMUST00000025095.8 NM_009187 Q61387 Scaf1 Silg81 uc008dsc.1 uc008dsc.2 uc008dsc.3 uc008dsc.4 Involved in the regulation of oxidative phosphorylation and energy metabolism (PubMed:23857330, PubMed:23812712). Necessary for the assembly of mitochondrial respiratory supercomplex (PubMed:23857330, PubMed:23812712). Interacts with the mitochondrial respiratory supercomplex. Mitochondrion inner membrane By estrogen and silica. Knockout homozygous mice manifest decreased mitochondrial respiratory activities and impaired formation of mitochondrial supercomplexes in muscles. KO animals have muscle weakness and exhibit heat production failure in the cold. Belongs to the cytochrome c oxidase VIIa family. regulation of oxidative phosphorylation cytochrome-c oxidase activity nucleolus mitochondrion mitochondrial inner membrane mitochondrial respiratory chain electron carrier activity membrane electron transport chain mitochondrial respiratory chain supercomplex assembly hydrogen ion transmembrane transport uc008dsc.1 uc008dsc.2 uc008dsc.3 uc008dsc.4 
ENSMUST00000025101.10 Dync2li1 ENSMUST00000025101.10 dynein cytoplasmic 2 light intermediate chain 1 (from RefSeq NM_172256.2) D2lic DC2L1_MOUSE ENSMUST00000025101.1 ENSMUST00000025101.2 ENSMUST00000025101.3 ENSMUST00000025101.4 ENSMUST00000025101.5 ENSMUST00000025101.6 ENSMUST00000025101.7 ENSMUST00000025101.8 ENSMUST00000025101.9 NM_172256 Q3TVA2 Q8K0T2 uc008dsy.1 uc008dsy.2 uc008dsy.3 uc008dsy.4 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles (By similarity) (PubMed:15371312). Involved in the regulation of ciliary length (By similarity). Light intermediate chain of the cytoplasmic dynein complex 2, a multisubunit complex composed at least of eleven different proteins. The cytoplasmic dynein 2 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs). Among them, a heavy chain (DYNC2H1), two intermediate chains (DYNC2I2 and DYNC2I1), a light intermediate chain (DYNC2LI1), and a light chain (DYNLT2B) are unique to the dynein-2 complex, but a subset of light chains are also shared by dynein-1 and dynein-2 complexes. Dynein-2 complex is built around two copies of cytoplasmic dynein 2 heavy chain 1 (DYNC2H1). The C-terminal region forms the motor domain, which converts the energy from ATP hydrolysis into movement. Its N-terminal region forms the tail, an extended structure that binds the other subunits and holds the two heavy chains in a homodimer. Interacts with DYNC2H1 (via N-terminus); this interaction stabilizes the dynein-2 complex structure. Cytoplasm Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to the apical cytoplasm. Specifically expressed by ciliated cells in brain, lung, spleen, testis and kidney (at protein level). Enriched in the ependymal layer lining the lateral ventricles (at protein level). Specifically expressed by monociliated cells of the ventral node from the late streak to early somite stage. Death before 11.5 dpc with defects in notochord and floor plate formation and a reduction of definitive endoderm. Mice also display anterior truncations of the forebrain, defects in the ventral body wall, in closure of the neural tube, and either an arrest of embryonic turning and heart looping or a randomization in their direction. Belongs to the dynein light intermediate chain family. Sequence=BAE35717.1; Type=Frameshift; Evidence=; motor activity cytoplasm centrosome microtubule organizing center cytoskeleton cytoplasmic dynein complex microtubule cilium axoneme multicellular organism development determination of left/right symmetry ATP-dependent microtubule motor activity, minus-end-directed cell projection organization dynein complex motile cilium intraciliary retrograde transport intraciliary transport involved in cilium assembly ciliary transition zone ciliary basal body cell projection apical part of cell dynein heavy chain binding cilium assembly regulation of cilium assembly intraciliary transport particle uc008dsy.1 uc008dsy.2 uc008dsy.3 uc008dsy.4 
ENSMUST00000025106.5 Polr2d ENSMUST00000025106.5 polymerase (RNA) II (DNA directed) polypeptide D, transcript variant 1 (from RefSeq NM_027002.4) ENSMUST00000025106.1 ENSMUST00000025106.2 ENSMUST00000025106.3 ENSMUST00000025106.4 NM_027002 Q6ZWW0 Q78KE6 Q9D7M8 RPB4_MOUSE uc008eim.1 uc008eim.2 uc008eim.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RPB4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex (By similarity). Nucleus Belongs to the eukaryotic RPB4 RNA polymerase subunit family. Sequence=AAH04810.1; Type=Erroneous initiation; Evidence=; nucleotide binding nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay P-body catalytic activity DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm DNA-directed RNA polymerase II, core complex cytosol DNA-templated transcription, initiation transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter nuclear speck RNA polymerase complex translation initiation factor binding mRNA export from nucleus in response to heat stress recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex cellular metabolic process positive regulation of translational initiation single-stranded DNA binding single-stranded RNA binding uc008eim.1 uc008eim.2 uc008eim.3 
ENSMUST00000025110.5 Syt4 ENSMUST00000025110.5 synaptotagmin IV (from RefSeq NM_009308.3) ENSMUST00000025110.1 ENSMUST00000025110.2 ENSMUST00000025110.3 ENSMUST00000025110.4 NM_009308 P40749 Q3UFC1 Q8BGH3 Q8BRL6 SYT4_MOUSE Syt3 uc008ehy.1 uc008ehy.2 uc008ehy.3 The protein encoded by this gene belongs to the synaptotagmin family. Members of this family are multi-domained, integral membrane proteins of synaptic vesicles, and are thought to serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. This gene is primarily expressed in the nervous tissues. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058208.1, SRR1660819.123904.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Synaptotagmin family member which does not bind Ca(2+). Plays a role in dendrite formation by melanocytes (By similarity). Synaptotagmin family member which does not bind Ca(2+) (By similarity). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (PubMed:29166604). Plays a role in dendrite formation by melanocytes (By similarity). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with KIF1A; the interaction increases in presence of calcium and decreases when SYT4 is phosphorylated at Ser-135. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane ; Single-pass membrane protein Expressed in many regions of the nervous system but is undetectable in extra neural tissues (PubMed:8058779). Unlike in other synaptotagmin family members, the first C2 domain/C2A does not bind Ca(2+) neither mediates Ca(2+)-dependent phospholipid binding. An aspartate-to-serine substitution in this domain inactivates Ca(2+)/phospho-lipid binding. Phosphorylation at Ser-135 by MAPK8/JNK1 reduces interaction with KIF1A and neuronal dense core vesicles mobility. Belongs to the synaptotagmin family. SNARE binding phosphatidylserine binding calcium ion binding calcium-dependent phospholipid binding Golgi apparatus plasma membrane exocytosis neurotransmitter secretion brain development memory positive regulation of glutamate secretion regulation of dopamine secretion membrane integral component of membrane vesicle-mediated transport syntaxin-1 binding calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis syntaxin binding cell junction regulation of endocytosis cell differentiation clathrin binding syntaxin-3 binding axon dendrite secretory granule membrane dense core granule regulation of vesicle fusion negative regulation of vesicle fusion cytoplasmic vesicle vesicle negative regulation of catecholamine secretion somatodendritic compartment protein homodimerization activity neuron projection neuronal cell body intracellular membrane-bounded organelle neuron projection terminus synapse negative regulation of calcium ion-dependent exocytosis metal ion binding negative regulation of neurotransmitter secretion protein heterodimerization activity negative regulation of short-term neuronal synaptic plasticity perinuclear region of cytoplasm synaptic vesicle transport negative regulation of protein secretion vesicle fusion with vesicle secretory granule maturation exocytic vesicle cellular response to calcium ion astrocyte projection presynapse postsynapse glutamatergic synapse integral component of neuronal dense core vesicle membrane positive regulation of dendrite extension negative regulation of dense core granule exocytosis positive regulation of dense core granule exocytosis negative regulation of retrograde trans-synaptic signaling by neuropeptide microvesicle negative regulation of synaptic vesicle exocytosis synaptic vesicle uc008ehy.1 uc008ehy.2 uc008ehy.3 
ENSMUST00000025117.14 Celf4 ENSMUST00000025117.14 CUGBP, Elav-like family member 4, transcript variant 35 (from RefSeq NM_001362309.1) Brul4 Brunol4 CELF4_MOUSE ENSMUST00000025117.1 ENSMUST00000025117.10 ENSMUST00000025117.11 ENSMUST00000025117.12 ENSMUST00000025117.13 ENSMUST00000025117.2 ENSMUST00000025117.3 ENSMUST00000025117.4 ENSMUST00000025117.5 ENSMUST00000025117.6 ENSMUST00000025117.7 ENSMUST00000025117.8 ENSMUST00000025117.9 NM_001362309 Q7TSY6 Q80Y76 Q811Z7 Q8BKM2 Q8BLM9 Q8BXA2 Q99PE0 uc012bap.1 uc012bap.2 uc012bap.3 RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q7TSY6-1; Sequence=Displayed; Name=2; IsoId=Q7TSY6-2; Sequence=VSP_026835, VSP_026838; Name=3; IsoId=Q7TSY6-3; Sequence=VSP_026838; Name=4; IsoId=Q7TSY6-4; Sequence=VSP_026837, VSP_026838, VSP_026839; Name=5; IsoId=Q7TSY6-5; Sequence=VSP_026835, VSP_026838, VSP_026840; Name=6; IsoId=Q7TSY6-6; Sequence=VSP_026834, VSP_026840; Name=7; IsoId=Q7TSY6-7; Sequence=VSP_026833, VSP_026836; Expressed strongly in skeletal muscle, heart and adipose tissue (at protein level). Expressed in the brain and cerebellum. Expressed in muscle and brain at 14 dpc (at protein level). Expressed in embryo at 7.5 dpc. Belongs to the CELF/BRUNOL family. Sequence=BAC31762.1; Type=Frameshift; Evidence=; alternative mRNA splicing, via spliceosome regulation of alternative mRNA splicing, via spliceosome in utero embryonic development nucleic acid binding RNA binding mRNA binding nucleus cytoplasm mRNA splice site selection mRNA processing RNA splicing pre-mRNA binding BRE binding negative regulation of mRNA splicing, via spliceosome positive regulation of mRNA splicing, via spliceosome negative regulation of excitatory postsynaptic potential regulation of retina development in camera-type eye ribonucleoprotein complex uc012bap.1 uc012bap.2 uc012bap.3 
ENSMUST00000025127.5 Mapre2 ENSMUST00000025127.5 microtubule-associated protein, RP/EB family, member 2, transcript variant 1 (from RefSeq NM_153058.4) ENSMUST00000025127.1 ENSMUST00000025127.2 ENSMUST00000025127.3 ENSMUST00000025127.4 MARE2_MOUSE NM_153058 Q3UF61 Q8BLZ6 Q8BYR6 Q8C177 Q8K109 Q8R001 uc008egf.1 uc008egf.2 uc008egf.3 uc008egf.4 May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). Interacts with DCTN1. Interacts with APC (via C-terminal). Interacts with monomeric and polymerized tubulin (By similarity). Interacts with SLAIN1 (PubMed:21646404). Interacts (via the N-terminal region) with BAG1 (By similarity). Cytoplasm Cytoplasm, cytoskeleton Note=Associated with the microtubule network. Accumulates at the plus end of microtubules (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R001-1; Sequence=Displayed; Name=2; IsoId=Q8R001-2; Sequence=VSP_012946; Composed of two functionally independent domains. The N- terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1 (By similarity). Belongs to the MAPRE family. protein binding cytoplasm microtubule organizing center cytoskeleton microtubule cytoplasmic microtubule focal adhesion cell cycle microtubule binding microtubule cytoskeleton protein kinase binding regulation of microtubule polymerization or depolymerization positive regulation of ARF protein signal transduction microtubule plus-end protein localization to microtubule identical protein binding positive regulation of GTPase activity microtubule plus-end binding spindle assembly spindle midzone cell division positive regulation of keratinocyte migration positive regulation of adherens junction organization protein localization to microtubule plus-end uc008egf.1 uc008egf.2 uc008egf.3 uc008egf.4 
ENSMUST00000025137.9 Thoc1 ENSMUST00000025137.9 THO complex 1, transcript variant 1 (from RefSeq NM_153552.4) ENSMUST00000025137.1 ENSMUST00000025137.2 ENSMUST00000025137.3 ENSMUST00000025137.4 ENSMUST00000025137.5 ENSMUST00000025137.6 ENSMUST00000025137.7 ENSMUST00000025137.8 Hpr1 NM_153552 Q8BWD5 Q8BXY3 Q8R3N6 THOC1_MOUSE uc008eal.1 uc008eal.2 uc008eal.3 Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity). Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1 (By similarity). Essential for early embryonic development. Required for normal gene expression during postnatal testis development. Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Binds to the hypophosphorylated form of RB1. Interacts with THOC2, DDX39B and RNA polymerase II (By similarity). Interacts with THOC5 (PubMed:16909111). Interacts with LUZP4 (By similarity). Nucleus Nucleus, nucleoplasm Nucleus matrix Cytoplasm, cytosol Note=Predominantly localized in the nucleus (PubMed:32776944). Shuttles between the nucleus and cytosol. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution (By similarity). In the inner ear, specifically expressed in inner and outer hair cells (at protein level). Widely expressed during embryonic development. An intact death domain is needed for apoptosis. Expression is altered specifically during apoptosis and is accompanied by the appearance of novel forms with smaller apparent molecular mass. Polyubiquitinated, leading to proteasomal degradation; probably involves NEDD4. Mice show early embryonic lethality and severely diminished fertility. regulation of DNA recombination transcription export complex THO complex THO complex part of transcription export complex nuclear chromosome, telomeric region DNA binding RNA binding protein binding nucleus nucleoplasm cytoplasm cytosol mRNA processing mRNA export from nucleus apoptotic process signal transduction RNA splicing nuclear matrix nuclear speck replication fork processing regulation of DNA-templated transcription, elongation positive regulation of DNA-templated transcription, elongation regulation of apoptotic process intercellular bridge viral mRNA export from host cell nucleus negative regulation of isotype switching to IgA isotypes mRNA transport negative regulation of DNA damage checkpoint uc008eal.1 uc008eal.2 uc008eal.3 
ENSMUST00000025142.13 Esco1 ENSMUST00000025142.13 establishment of sister chromatid cohesion N-acetyltransferase 1 (from RefSeq NM_001081222.1) B9EKQ9 ENSMUST00000025142.1 ENSMUST00000025142.10 ENSMUST00000025142.11 ENSMUST00000025142.12 ENSMUST00000025142.2 ENSMUST00000025142.3 ENSMUST00000025142.4 ENSMUST00000025142.5 ENSMUST00000025142.6 ENSMUST00000025142.7 ENSMUST00000025142.8 ENSMUST00000025142.9 ESCO1_MOUSE Kiaa1911 NM_001081222 Q69Z69 Q8BQI2 Q8BR47 Q922F5 uc008eav.1 uc008eav.2 uc008eav.3 Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3. Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; Evidence=; The subunit structure is controversial. Monomer. Homodimer. Nucleus Chromosome Note=Nuclear at interphase, associated with chromosomes during mitosis. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q69Z69-1; Sequence=Displayed; Name=2; IsoId=Q69Z69-2; Sequence=VSP_014031, VSP_014032; Name=3; IsoId=Q69Z69-3; Sequence=VSP_014033, VSP_014034; The N-terminal region seems to be responsible for association with chromosomes, thus excluding any involvement of the Zn finger in this process. Phosphorylated during mitosis. Belongs to the acetyltransferase family. ECO subfamily. Sequence=AAH08220.1; Type=Erroneous initiation; Evidence=; Sequence=BAC33830.1; Type=Frameshift; Evidence=; Sequence=BAD32575.1; Type=Erroneous initiation; Evidence=; chromatin nucleus chromosome regulation of DNA replication cell cycle sister chromatid cohesion N-acetyltransferase activity zinc ion binding acetyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-lysine acetylation post-translational protein acetylation identical protein binding metal ion binding peptide-lysine-N-acetyltransferase activity uc008eav.1 uc008eav.2 uc008eav.3 
ENSMUST00000025161.10 Tapbp ENSMUST00000025161.10 TAP binding protein, transcript variant 1 (from RefSeq NM_001025313.1) ENSMUST00000025161.1 ENSMUST00000025161.2 ENSMUST00000025161.3 ENSMUST00000025161.4 ENSMUST00000025161.5 ENSMUST00000025161.6 ENSMUST00000025161.7 ENSMUST00000025161.8 ENSMUST00000025161.9 NM_001025313 Q3TCU5 Q3TCU5_MOUSE Tapbp uc008caf.1 uc008caf.2 uc008caf.3 Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein MHC class I protein complex assembly membrane integral component of membrane antigen processing and presentation of endogenous peptide antigen via MHC class I MHC class I peptide loading complex macromolecular complex assembly uc008caf.1 uc008caf.2 uc008caf.3 
ENSMUST00000025163.14 Pfdn6 ENSMUST00000025163.14 prefoldin subunit 6, transcript variant 1 (from RefSeq NM_010385.2) ENSMUST00000025163.1 ENSMUST00000025163.10 ENSMUST00000025163.11 ENSMUST00000025163.12 ENSMUST00000025163.13 ENSMUST00000025163.2 ENSMUST00000025163.3 ENSMUST00000025163.4 ENSMUST00000025163.5 ENSMUST00000025163.6 ENSMUST00000025163.7 ENSMUST00000025163.8 ENSMUST00000025163.9 H2-Ke2 NM_010385 Pfdn6 Q792E4 Q792E4_MOUSE uc008cah.1 uc008cah.2 uc008cah.3 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Belongs to the prefoldin subunit beta family. protein folding prefoldin complex unfolded protein binding chaperone binding chaperone-mediated protein complex assembly uc008cah.1 uc008cah.2 uc008cah.3 
ENSMUST00000025166.14 Cdh2 ENSMUST00000025166.14 cadherin 2 (from RefSeq NM_007664.5) CADH2_MOUSE ENSMUST00000025166.1 ENSMUST00000025166.10 ENSMUST00000025166.11 ENSMUST00000025166.12 ENSMUST00000025166.13 ENSMUST00000025166.2 ENSMUST00000025166.3 ENSMUST00000025166.4 ENSMUST00000025166.5 ENSMUST00000025166.6 ENSMUST00000025166.7 ENSMUST00000025166.8 ENSMUST00000025166.9 NM_007664 P15116 Q64260 Q6GU11 uc008edx.1 uc008edx.2 uc008edx.3 uc008edx.4 This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Mice lacking the encoded protein exhibit severe developmental defects resulting in embryonic death. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB008811.1, AK146981.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell (PubMed:2762814, PubMed:11433297, PubMed:17988630, PubMed:9655503, PubMed:25253890). Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence (PubMed:24952463). Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (PubMed:26750727). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Homodimer (via extracellular region) (PubMed:21300292, PubMed:25253890). Can also form heterodimers with other cadherins (via extracellular region) (PubMed:25253890). Dimerization occurs in trans, i.e. with a cadherin chain from another cell (PubMed:21300292, PubMed:25253890). Interacts with CDCP1 (By similarity). Interacts with PCDH8; this complex may also include TAOK2 (By similarity). The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway (By similarity). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (PubMed:11433297). May interact with OBSCN (via protein kinase domain 2) (PubMed:23392350). Interacts with FBXO45 (By similarity). P15116; P15116: Cdh2; NbExp=4; IntAct=EBI-397974, EBI-397974; P15116; P18031: PTPN1; Xeno; NbExp=3; IntAct=EBI-397974, EBI-968788; Cell membrane ingle-pass type I membrane protein Cell membrane, sarcolemma Cell junction Cell junction, adherens junction Cell junction, desmosome Cell surface Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes (PubMed:26403541). Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes (PubMed:23392350). Expressed in cardiac muscle (at protein level). Expressed at all stages of testicular development with the highest expression levels found in testes of 21-day-old mice (PubMed:8879495). Expressed at the outer limiting membrane of the retina at 3 months of age (PubMed:23001562). Expression is restricted to the lens stalk region between 10 and 11 dpc. At later stages (17.5 dpc), it is expressed in the developing lens and corneal endothelium (PubMed:31650526). Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1. Cleaved by MMP24 (PubMed:19805319, PubMed:24952463). Ectodomain cleavage leads to the generation of a soluble 90 kDa N-terminal soluble fragment and a 45 kDa membrane-bound C-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa (PubMed:24952463). Cleavage in neural stem cells by MMP24 affects CDH2- mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (PubMed:24952463). May be phosphorylated by OBSCN. O-glycosylated on Ser and Thr residues. Embryonic lethality. cell morphogenesis calcium ion binding protein binding cytoplasm plasma membrane integral component of plasma membrane cell-cell junction adherens junction cell-cell adherens junction fascia adherens cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules synapse assembly beta-catenin binding cytoskeletal protein binding regulation of signal transduction cell surface glial cell differentiation postsynaptic density intercalated disc membrane integral component of membrane basolateral plasma membrane apical plasma membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex cell migration enzyme binding protein kinase binding protein phosphatase binding telencephalon development cerebral cortex development lamellipodium cell junction T-tubule cortical actin cytoskeleton regulation of myelination regulation of protein localization macromolecular complex adherens junction organization regulation of Rho protein signal transduction sarcolemma identical protein binding protein homodimerization activity neuron projection positive regulation of MAPK cascade cell-cell adhesion mediated by cadherin plasma membrane raft macromolecular complex binding apical part of cell synapse alpha-catenin binding gamma-catenin binding cadherin binding metal ion binding blood vessel morphogenesis brain morphogenesis homeostasis of number of cells regulation of axonogenesis modulation of synaptic transmission nitric-oxide synthase binding striated muscle cell differentiation protein heterooligomerization regulation of synaptic transmission, glutamatergic radial glial cell differentiation neuroepithelial cell differentiation regulation of oligodendrocyte progenitor proliferation protein localization to plasma membrane negative regulation of canonical Wnt signaling pathway neuroligin clustering involved in postsynaptic membrane assembly neuronal stem cell population maintenance cell-cell adhesion glutamatergic synapse integral component of presynaptic active zone membrane integral component of postsynaptic specialization membrane regulation of postsynaptic density protein 95 clustering positive regulation of synaptic vesicle clustering uc008edx.1 uc008edx.2 uc008edx.3 uc008edx.4 
ENSMUST00000025170.11 Wdr46 ENSMUST00000025170.11 WD repeat domain 46 (from RefSeq NM_020603.2) Bing4 ENSMUST00000025170.1 ENSMUST00000025170.10 ENSMUST00000025170.2 ENSMUST00000025170.3 ENSMUST00000025170.4 ENSMUST00000025170.5 ENSMUST00000025170.6 ENSMUST00000025170.7 ENSMUST00000025170.8 ENSMUST00000025170.9 NM_020603 Q9Z0H1 WDR46_MOUSE uc008cai.1 uc008cai.2 uc008cai.3 Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with DDX21, NCL, NOP2 and EBNA1BP2. Nucleus, nucleolus maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleus nucleolus small-subunit processome uc008cai.1 uc008cai.2 uc008cai.3 
ENSMUST00000025178.17 Vps52 ENSMUST00000025178.17 VPS52 GARP complex subunit, transcript variant 1 (from RefSeq NM_172620.4) ENSMUST00000025178.1 ENSMUST00000025178.10 ENSMUST00000025178.11 ENSMUST00000025178.12 ENSMUST00000025178.13 ENSMUST00000025178.14 ENSMUST00000025178.15 ENSMUST00000025178.16 ENSMUST00000025178.2 ENSMUST00000025178.3 ENSMUST00000025178.4 ENSMUST00000025178.5 ENSMUST00000025178.6 ENSMUST00000025178.7 ENSMUST00000025178.8 ENSMUST00000025178.9 NM_172620 Q6P4N7 Q8BQ15 Q8C754 Q9QWT6 Q9QWV2 VPS52_MOUSE uc008cam.1 uc008cam.2 uc008cam.3 Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin. EIPR1 interacts with both EARP and GARP complexes and mediates the recruitment of the GARP complex to the trans-Golgi network. Interacts with RAB6A and STX10. Interacts with BLTP3B. Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Recycling endosome Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C754-1; Sequence=Displayed; Name=2; IsoId=Q8C754-2; Sequence=VSP_016234, VSP_016235; Belongs to the VPS52 family. Sequence=AAC69899.1; Type=Erroneous gene model prediction; Evidence=; Sequence=AAC97979.1; Type=Erroneous gene model prediction; Evidence=; GARP complex endosome Golgi apparatus cytosol Golgi to vacuole transport lysosomal transport endosome membrane ectodermal cell differentiation protein transport membrane Rab GTPase binding syntaxin binding endocytic recycling retrograde transport, endosome to Golgi perinuclear region of cytoplasm embryonic ectodermal digestive tract development recycling endosome EARP complex uc008cam.1 uc008cam.2 uc008cam.3 
ENSMUST00000025183.9 Ring1 ENSMUST00000025183.9 ring finger protein 1 (from RefSeq NM_009066.3) ENSMUST00000025183.1 ENSMUST00000025183.2 ENSMUST00000025183.3 ENSMUST00000025183.4 ENSMUST00000025183.5 ENSMUST00000025183.6 ENSMUST00000025183.7 ENSMUST00000025183.8 NM_009066 O35730 Q3U242 Q3U333 Q4FK33 Q63ZX8 Q921Z8 RING1_MOUSE Ring1 Ring1A Rnf1 uc008cas.1 uc008cas.2 uc008cas.3 Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Component of chromatin-associated Polycomb (PcG) complexes. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2 MBLR, L3MBTL2 and YAF2. Interacts with CBX2 and PCGF6. Component of a PRC1-like complex. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RNF2/RING2. Interacts with PHC2, PCGF2, RNF2; CBX6, CBX7 and CBX8. Interacts with BMI1 (By similarity). Interacts with MN1 (By similarity). Interacts with USP26. O35730; P25916: Bmi1; NbExp=4; IntAct=EBI-929310, EBI-927401; O35730; Q9QXV1: Cbx8; NbExp=2; IntAct=EBI-929310, EBI-1216641; O35730; Q9QWH1: Phc2; NbExp=2; IntAct=EBI-929310, EBI-642357; O35730; Q9CQJ4: Rnf2; NbExp=3; IntAct=EBI-929310, EBI-927321; O35730; Q8CCI5: Rybp; NbExp=4; IntAct=EBI-929310, EBI-929290; Nucleus speckle Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O35730-1; Sequence=Displayed; Name=2; IsoId=O35730-2; Sequence=VSP_017695; Name=3; IsoId=O35730-3; Sequence=VSP_017696, VSP_017697; Expressed in cells of the central nervous system (CNS) from 8.5 to 11.5 dpc. Expressed in the hindbrain (in the rhombomere boundaries) at 10.5 dpc. Expressed in CNS (ventricular zone and spinal cord), peripheral nervous system (PNS, sensory cranial and spinal ganglia), olfactory and tongue epithelia at 13.5 dpc. Expressed in CNS, thymus, various epithelial cell types including the olfactory, tooth and tongue epithelia at 15.5 dpc. Sequence=AAH09070.1; Type=Erroneous initiation; Evidence=; ubiquitin ligase complex sex chromatin chromatin binding protein binding nucleus nucleoplasm cytosol chromatin organization anterior/posterior pattern specification protein ubiquitination histone ubiquitination nuclear body nuclear speck transferase activity PcG protein complex PRC1 complex histone H2A monoubiquitination negative regulation of transcription, DNA-templated metal ion binding camera-type eye morphogenesis regulation of catalytic activity ubiquitin protein ligase activity ubiquitin-protein transferase activator activity uc008cas.1 uc008cas.2 uc008cas.3 
ENSMUST00000025186.16 Slc39a7 ENSMUST00000025186.16 solute carrier family 39 (zinc transporter), member 7, transcript variant 1 (from RefSeq NM_008202.2) ENSMUST00000025186.1 ENSMUST00000025186.10 ENSMUST00000025186.11 ENSMUST00000025186.12 ENSMUST00000025186.13 ENSMUST00000025186.14 ENSMUST00000025186.15 ENSMUST00000025186.2 ENSMUST00000025186.3 ENSMUST00000025186.4 ENSMUST00000025186.5 ENSMUST00000025186.6 ENSMUST00000025186.7 ENSMUST00000025186.8 ENSMUST00000025186.9 H2-Ke4 Hke4 NM_008202 Q31125 Q3TVU6 Q9Z1W1 S39A7_MOUSE uc008caw.1 uc008caw.2 uc008caw.3 uc008caw.4 Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (PubMed:15705588). Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation (By similarity). Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function (PubMed:28545780, PubMed:27736879). Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (PubMed:31266232). Has a protective role against ER stress in different biological contexts (PubMed:31266232). Mediates Zn(2+)-induced ferroptosis (By similarity). Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence=; Homodimer. Q31125; P25118: Tnfrsf1a; NbExp=3; IntAct=EBI-644519, EBI-518014; Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein Widely expressed (PubMed:15705588, PubMed:2294398). Highly expressed in the intestinal crypts (PubMed:27736879). Down-regulated in an insulin-resistant, and high-fat diet state. Methylation at some His residue by METTL9 leads to reduced zinc- binding. Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release. Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. Sequence=AAA37767.1; Type=Frameshift; Evidence=; zinc ion transmembrane transporter activity protein binding nucleoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus ion transport zinc II ion transport cellular zinc ion homeostasis membrane integral component of membrane metal ion transport metal ion transmembrane transporter activity transmembrane transport zinc II ion transmembrane transport uc008caw.1 uc008caw.2 uc008caw.3 uc008caw.4 
ENSMUST00000025192.8 H2-Oa ENSMUST00000025192.8 histocompatibility 2, O region alpha locus (from RefSeq NM_008206.2) ENSMUST00000025192.1 ENSMUST00000025192.2 ENSMUST00000025192.3 ENSMUST00000025192.4 ENSMUST00000025192.5 ENSMUST00000025192.6 ENSMUST00000025192.7 H2-Oa H2-Oalpha NM_008206 Q9QWV1 Q9QWV1_MOUSE uc008cbg.1 uc008cbg.2 uc008cbg.3 uc008cbg.4 Membrane ; Single- pass type I membrane protein Belongs to the MHC class II family. adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of antigen processing and presentation of peptide antigen via MHC class II immune response membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II MHC class II protein complex binding MHC class II protein complex regulation of T cell differentiation uc008cbg.1 uc008cbg.2 uc008cbg.3 uc008cbg.4 
ENSMUST00000025193.14 Brd2 ENSMUST00000025193.14 bromodomain containing 2, transcript variant 5 (from RefSeq NM_001424772.1) BRD2_MOUSE ENSMUST00000025193.1 ENSMUST00000025193.10 ENSMUST00000025193.11 ENSMUST00000025193.12 ENSMUST00000025193.13 ENSMUST00000025193.2 ENSMUST00000025193.3 ENSMUST00000025193.4 ENSMUST00000025193.5 ENSMUST00000025193.6 ENSMUST00000025193.7 ENSMUST00000025193.8 ENSMUST00000025193.9 Fsrg1 Kiaa4005 NM_001424772 O54795 O88411 Q3UGI0 Q5DTS6 Q794H7 Q794H9 Q7JJ13 Q99PC5 Ring3 uc008cbj.1 uc008cbj.2 uc008cbj.3 uc008cbj.4 uc008cbj.5 Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis. Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13' (By similarity). Nucleus te=Detected on chromatin and nucleosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7JJ13-1; Sequence=Displayed; Name=2; IsoId=Q7JJ13-2; Sequence=VSP_022601; Predominantly expressed in the testis, followed by ovary, placenta, embryo and to a lower extent in somatic tissues. One bromodomain is sufficient for a partial interaction with histone H4 acetylated at 'Lys-13'. Sequence=BAD90273.1; Type=Erroneous initiation; Evidence=; chromatin binding nucleus nucleoplasm cytoplasm chromatin organization nucleosome assembly regulation of transcription from RNA polymerase II promoter nuclear speck lysine-acetylated histone binding uc008cbj.1 uc008cbj.2 uc008cbj.3 uc008cbj.4 uc008cbj.5 
ENSMUST00000025196.9 Psmb8 ENSMUST00000025196.9 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) (from RefSeq NM_010724.2) ENSMUST00000025196.1 ENSMUST00000025196.2 ENSMUST00000025196.3 ENSMUST00000025196.4 ENSMUST00000025196.5 ENSMUST00000025196.6 ENSMUST00000025196.7 ENSMUST00000025196.8 Lmp7 Mc13 NM_010724 P28063 PSB8_MOUSE Q3UK42 Q64300 Q792S8 Q7TMX9 Q91VH7 uc012apv.1 uc012apv.2 uc012apv.3 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. May participate in the inflammatory response pathway. Required for adipocyte differentiation (PubMed:21881205, PubMed:22341445, PubMed:8066463). May be involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (By similarity). Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB5. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Directly interacts with POMP. Interacts with TAP1. Cytoplasm Nucleus Detected in liver (at protein level). Expressed in spleen, thymus, lung, liver, heart and, at a very low level, in kidney. Not expressed in brain nor testis. Up-regulated by interferon gamma (at protein level). Up- regulated by IRF1. Down-regulated in spleen by deoxynivalenol (DON), a mycotoxin that alters immune functions. Down-regulated by the selective inhibitor PR-957. Up-regulated by heat shock treatment. Down-regulated by EGR1 in neuronal cells. Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity. The allele, LMP7k/LMP7s/LMPf/LMP7r/LMPcas4/LMPg7 found in strains NMRI, B10.BR, SJL, A.CA, B10.RIII, B10.cas4 and NOD may be post-translationally modified. Allele LMP7q is found in strain DBA/1J. Belongs to the peptidase T1B family. Sequence=CAA45780.1; Type=Erroneous initiation; Evidence=; proteasome complex immune system process endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteolysis peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, beta-subunit complex antigen processing and presentation cell differentiation proteasome-mediated ubiquitin-dependent protein catabolic process fat cell differentiation proteolysis involved in cellular protein catabolic process regulation of endopeptidase activity spermatoproteasome complex uc012apv.1 uc012apv.2 uc012apv.3 
ENSMUST00000025197.6 Tap2 ENSMUST00000025197.6 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (from RefSeq NM_011530.3) ENSMUST00000025197.1 ENSMUST00000025197.2 ENSMUST00000025197.3 ENSMUST00000025197.4 ENSMUST00000025197.5 H2 TAP2 NM_011530 Q792S7 Q792S7_MOUSE RP23-123G8.1-001 Tap2 uc008cbx.1 uc008cbx.2 uc008cbx.3 uc008cbx.4 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with Tap1 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051257.1, AK159200.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Reaction=a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:65972, Rhea:RHEA-COMP:16941, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:166823, ChEBI:CHEBI:456216; EC=7.4.2.14; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65973; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. nucleotide binding ATP binding peptide-transporting ATPase activity peptide transport membrane integral component of membrane ATPase activity antigen processing and presentation of endogenous peptide antigen via MHC class I integral component of endoplasmic reticulum membrane MHC protein binding ATPase activity, coupled to transmembrane movement of substances TAP complex transmembrane transport peptide transmembrane transporter activity uc008cbx.1 uc008cbx.2 uc008cbx.3 uc008cbx.4 
ENSMUST00000025198.15 Btnl2 ENSMUST00000025198.15 butyrophilin-like 2 (from RefSeq NM_079835.2) A6X8K1 BTNL2_MOUSE Btnl2 ENSMUST00000025198.1 ENSMUST00000025198.10 ENSMUST00000025198.11 ENSMUST00000025198.12 ENSMUST00000025198.13 ENSMUST00000025198.14 ENSMUST00000025198.2 ENSMUST00000025198.3 ENSMUST00000025198.4 ENSMUST00000025198.5 ENSMUST00000025198.6 ENSMUST00000025198.7 ENSMUST00000025198.8 ENSMUST00000025198.9 Gm315 NM_079835 Ng9 O70355 Q3UW94 uc008ccl.1 uc008ccl.2 uc008ccl.3 uc008ccl.4 Negative regulator of T-cell proliferation. Membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O70355-1; Sequence=Displayed; Name=2; IsoId=O70355-2; Sequence=VSP_022147; Highly expressed in intestine and at reduced levels in lung and stomach. Also expressed in thymus, spleen, lymph nodes, T- cells, B-cells, and macrophages. Belongs to the immunoglobulin superfamily. BTN/MOG family. Sequence=AAC05288.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence=; receptor binding external side of plasma membrane membrane integral component of membrane positive regulation of T cell proliferation regulation of immune response T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway positive regulation of interleukin-2 secretion uc008ccl.1 uc008ccl.2 uc008ccl.3 uc008ccl.4 
ENSMUST00000025204.7 Pfdn1 ENSMUST00000025204.7 prefoldin 1 (from RefSeq NM_026027.3) ENSMUST00000025204.1 ENSMUST00000025204.2 ENSMUST00000025204.3 ENSMUST00000025204.4 ENSMUST00000025204.5 ENSMUST00000025204.6 NM_026027 Pfdn1 Q9CQF7 Q9CQF7_MOUSE uc008enk.1 uc008enk.2 uc008enk.3 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Belongs to the prefoldin subunit beta family. protein folding prefoldin complex protein binding involved in protein folding unfolded protein binding uc008enk.1 uc008enk.2 uc008enk.3 
ENSMUST00000025208.7 Dnajc18 ENSMUST00000025208.7 DnaJ heat shock protein family (Hsp40) member C18 (from RefSeq NM_029669.4) DJC18_MOUSE ENSMUST00000025208.1 ENSMUST00000025208.2 ENSMUST00000025208.3 ENSMUST00000025208.4 ENSMUST00000025208.5 ENSMUST00000025208.6 NM_029669 Q8R371 Q9CZJ9 uc008emq.1 uc008emq.2 uc008emq.3 uc008emq.4 uc008emq.5 Endoplasmic reticulum membrane ; Single-pass membrane protein endoplasmic reticulum membrane membrane integral component of membrane ER-associated ubiquitin-dependent protein catabolic process Hsp70 protein binding chaperone mediated protein folding requiring cofactor cellular response to misfolded protein uc008emq.1 uc008emq.2 uc008emq.3 uc008emq.4 uc008emq.5 
ENSMUST00000025209.12 Spata24 ENSMUST00000025209.12 spermatogenesis associated 24, transcript variant 2 (from RefSeq NM_029485.2) ENSMUST00000025209.1 ENSMUST00000025209.10 ENSMUST00000025209.11 ENSMUST00000025209.2 ENSMUST00000025209.3 ENSMUST00000025209.4 ENSMUST00000025209.5 ENSMUST00000025209.6 ENSMUST00000025209.7 ENSMUST00000025209.8 ENSMUST00000025209.9 NM_029485 Q5MMR1 Q6P926 Q9D4P6 SPA24_MOUSE Tipt Tipt2 uc008emn.1 uc008emn.2 uc008emn.3 uc008emn.4 Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis. Homodimer. Interacts with CBX3, CBX5, GMNN, GTF2B, TBPL1 and the polycomb proteins PHCF2, RNF2 and SCMH1 but not with CBX1 or PCGF2. Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Associated with chromatin. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P926-1; Sequence=Displayed; Name=2; IsoId=Q6P926-2; Sequence=VSP_032868, VSP_032869; Name=3; IsoId=Q6P926-3; Sequence=VSP_032869; Testis-specific (at protein level). In the embryo, abundant at 7.5 dpc and 8.5 dpc with higher levels at 9.5 dpc, 10.5 dpc and 11.5 dpc. Expression is low during the first two weeks after birth, increases during the third week and remains elevated in 4-week-old and adult mice. During spermatogenesis, expressed in spermatocytes mainly from zygotene to meiotic metaphase divisions and increases post-meiotically in round spermatids. Expression decreases in stage IV spermatids. Belongs to the SPATA24 family. DNA binding protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol multicellular organism development spermatogenesis biological_process cell differentiation protein homodimerization activity uc008emn.1 uc008emn.2 uc008emn.3 uc008emn.4 
ENSMUST00000025211.6 Mzb1 ENSMUST00000025211.6 marginal zone B and B1 cell-specific protein 1 (from RefSeq NM_027222.3) D2IYS1 ENSMUST00000025211.1 ENSMUST00000025211.2 ENSMUST00000025211.3 ENSMUST00000025211.4 ENSMUST00000025211.5 MZB1_MOUSE NM_027222 Pacap Q6P3D3 Q8BU13 Q8K2M5 Q9D8I1 uc008emm.1 uc008emm.2 uc008emm.3 uc008emm.4 uc008emm.5 Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance. Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner. Endoplasmic reticulum Endoplasmic reticulum lumen Secreted Expressed predominantly in the spleen and lymph nodes. Abundantly expressed in marginal zone B and B1 cells. High expression in mesenteric adipose tissue (MAT). Expressed also in pancreas, perigonadal adipose tissue (PAT), uterus, subcutaneous adipose tissue, heart, muscle, ovary and liver. Very low expression is detected in brown adipose tissue. In PAT, significantly higher expression in stromal-vascular cell than in adipocytes. Expressed in macrophage RAW 264.7 cell line. Down-regulated in For-knockout female MAT at 5 months (obese state) followed by steep up-regulation at 9 months (prediabetic condition) when mutants progress towards the metabolic syndrome. Up-regulated during plasma cell differentiation. Forms an interchain disulfide bond with IgM monomers. Belongs to the MZB1 family. positive regulation of immunoglobulin biosynthetic process molecular_function protein binding extracellular region cytoplasm endoplasmic reticulum endoplasmic reticulum lumen positive regulation of cell proliferation regulation of B cell proliferation integrin activation endoplasmic reticulum chaperone complex regulation of cell proliferation regulation of insulin receptor signaling pathway uc008emm.1 uc008emm.2 uc008emm.3 uc008emm.4 uc008emm.5 
ENSMUST00000025212.8 Slc23a1 ENSMUST00000025212.8 solute carrier family 23 (nucleobase transporters), member 1 (from RefSeq NM_011397.4) ENSMUST00000025212.1 ENSMUST00000025212.2 ENSMUST00000025212.3 ENSMUST00000025212.4 ENSMUST00000025212.5 ENSMUST00000025212.6 ENSMUST00000025212.7 NM_011397 Q3TNA2 Q8C3M2 Q91WR7 Q9Z2J0 S23A1_MOUSE Svct1 Yspl3 uc008eml.1 uc008eml.2 uc008eml.3 uc008eml.4 Sodium:L-ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each L- ascorbate (PubMed:36749388). Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber (PubMed:36749388) (By similarity). Reaction=L-ascorbate(out) + 2 Na(+)(out) = L-ascorbate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:69883, ChEBI:CHEBI:29101, ChEBI:CHEBI:38290; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69884; Evidence=; Reaction=2 Na(+)(out) + urate(out) = 2 Na(+)(in) + urate(in); Xref=Rhea:RHEA:76339, ChEBI:CHEBI:17775, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76340; Evidence=; Kinetic parameters: KM=646 uM for urate ; Vmax=430.1 pmol/min/mg enzyme toward urate ; Cell membrane ; Multi-pass membrane protein Expressed in kidney (at protein level). Phosphorylated. Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. cytoplasm plasma membrane brush border ion transport sodium ion transport brain development L-ascorbate:sodium symporter activity response to toxic substance basal plasma membrane sodium ion transmembrane transporter activity L-ascorbic acid transporter activity symporter activity L-ascorbic acid transport membrane integral component of membrane apical plasma membrane transmembrane transporter activity lung development dehydroascorbic acid transporter activity sodium ion transmembrane transport intracellular organelle transmembrane transport dehydroascorbic acid transport sodium-dependent L-ascorbate transmembrane transporter activity transepithelial L-ascorbic acid transport uc008eml.1 uc008eml.2 uc008eml.3 uc008eml.4 
ENSMUST00000025215.10 Sil1 ENSMUST00000025215.10 SIL1 nucleotide exchange factor, transcript variant 2 (from RefSeq NM_030749.2) ENSMUST00000025215.1 ENSMUST00000025215.2 ENSMUST00000025215.3 ENSMUST00000025215.4 ENSMUST00000025215.5 ENSMUST00000025215.6 ENSMUST00000025215.7 ENSMUST00000025215.8 ENSMUST00000025215.9 NM_030749 Q91V34 Q9EPK6 SIL1_MOUSE uc008emc.1 uc008emc.2 uc008emc.3 uc008emc.4 uc008emc.5 Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. Interacts with HSPA5. Endoplasmic reticulum lumen Expressed in several areas of the brain including the cerebellum, cerebral cortex, cortical neurons, glial cells of white matter, hippocampus, olfactory bulb, Purkinje cells, inferior olive and the choroids plexus. Also expressed in the eye and skeletal muscle. Expressed in the developing retina and epithelial cells of the lens at 12.5 dpc. Expressed in the developing cerebral cortex at 15.5 dpc. N-glycosylated. Ubiquitinated by the CRL2(FEM1A) and CRL2(FEM1C) complexes, which recognize the -Lys-Xaa-Xaa-Arg C-degron at the C-terminus, leading to its degradation. Mice develop adult-onset ataxia with cerebellar Purkinje cell loss. Affected cells have intracellular protein accumulations in the endoplasmic reticulum and the nucleus. Belongs to the SIL1 family. adenyl-nucleotide exchange factor activity cytoplasm endoplasmic reticulum endoplasmic reticulum lumen protein transport regulation of catalytic activity uc008emc.1 uc008emc.2 uc008emc.3 uc008emc.4 uc008emc.5 
ENSMUST00000025217.11 Hspa9 ENSMUST00000025217.11 heat shock protein 9 (from RefSeq NM_010481.2) ENSMUST00000025217.1 ENSMUST00000025217.10 ENSMUST00000025217.2 ENSMUST00000025217.3 ENSMUST00000025217.4 ENSMUST00000025217.5 ENSMUST00000025217.6 ENSMUST00000025217.7 ENSMUST00000025217.8 ENSMUST00000025217.9 GRP75_MOUSE Grp75 Hsp74 Hspa9 Hspa9a NM_010481 P38647 Q3TW93 Q3UVN1 Q3V015 Q7TSZ0 Q9CQ05 uc008elv.1 uc008elv.2 uc008elv.3 uc008elv.4 uc008elv.5 uc008elv.6 Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis (PubMed:26702583). Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (By similarity). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823). May play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (By similarity). May play a role in the control of cell proliferation and cellular aging (PubMed:8454632). Interacts strongly with the intermediate form of FXN and weakly with its mature form. Interacts with HSCB. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with DNLZ, the interaction is required to prevent self-aggregation. Interacts with TESPA1. Interacts with PDPN. Interacts with NFU1, NFS1 and ISCU. Interacts with TP53; the interaction promotes TP53 degradation (By similarity). Interacts (via SBD domain) with UBXN2A; the interaction with UBXN2A inhibits HSPA9/MOT-2 interaction with and degradation of TP53, thereby promotes TP53 translocation to the nucleus (By similarity). Mitochondrion Nucleus, nucleolus Cytoplasm Expressed in embryonic fibroblasts (at protein level). Not induced by heat shock, instead protein abundance is decreased. Two forms of the protein have been found, MOT-1, found in mortal cells and MOT-2, found in immortal cells. The sequence of MOT-2 is shown here. Belongs to the heat shock protein 70 family. nucleotide binding protein binding ATP binding nucleus nucleolus cytoplasm mitochondrion mitochondrial matrix protein folding protein export from nucleus response to unfolded protein iron-sulfur cluster assembly ATPase activity fibroblast growth factor binding enzyme binding erythrocyte differentiation heat shock protein binding ubiquitin protein ligase binding cellular response to heat cellular response to unfolded protein protein refolding ATPase activity, coupled mitochondrial nucleoid myelin sheath protein binding involved in protein folding regulation of erythrocyte differentiation negative regulation of erythrocyte differentiation protein autophosphorylation unfolded protein binding chaperone mediated protein folding requiring cofactor chaperone binding misfolded protein binding negative regulation of cell death negative regulation of hematopoietic stem cell differentiation negative regulation of hemopoiesis uc008elv.1 uc008elv.2 uc008elv.3 uc008elv.4 uc008elv.5 uc008elv.6 
ENSMUST00000025218.8 Etf1 ENSMUST00000025218.8 eukaryotic translation termination factor 1 (from RefSeq NM_144866.3) ENSMUST00000025218.1 ENSMUST00000025218.2 ENSMUST00000025218.3 ENSMUST00000025218.4 ENSMUST00000025218.5 ENSMUST00000025218.6 ENSMUST00000025218.7 ERF1_MOUSE NM_144866 Q3TPZ6 Q8BWY3 Q91VH9 uc008elu.1 uc008elu.2 uc008elu.3 Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons. The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA. Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site, followed by hydrolysis of peptidyl-tRNA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL- mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. Component of the eRF1-eRF3-GTP ternary complex, composed of ETF1/ERF1 and eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) and GTP. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with JMJD4. The ETF1-GSPT1 complex interacts with JMJD4. (Microbial infection) Interacts with Moloney murine leukemia virus (MoLV) reverse transcriptase/Ribonuclease H p80 (via RT and RNase domains); this interaction is essential for translational readthrough of amber codon between viral gag and pol genes. Interacts with MoLV Gag-Pol precursor. Cytoplasm Hydroxylation at Lys-63 by JMJD4 promotes its translational termination efficiency. Methylated at Gln-185 by N6AMT1. Ubiquitinated via 'Lys-6'-linked polyubiquitin chains by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling), leading to its degradation by the proteasome and rescue of stalled ribosomes. Belongs to the eukaryotic release factor 1 family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cytoplasmic translational termination translation release factor activity cytoplasm cytosol translation translational termination regulation of translational termination protein methylation translation termination factor activity viral process translation release factor activity, codon specific translation release factor complex sequence-specific mRNA binding uc008elu.1 uc008elu.2 uc008elu.3 
ENSMUST00000025223.9 Cyp21a1 ENSMUST00000025223.9 cytochrome P450, family 21, subfamily a, polypeptide 1 (from RefSeq NM_009995.2) A0A0R4J048 A0A0R4J048_MOUSE Cyp21a1 ENSMUST00000025223.1 ENSMUST00000025223.2 ENSMUST00000025223.3 ENSMUST00000025223.4 ENSMUST00000025223.5 ENSMUST00000025223.6 ENSMUST00000025223.7 ENSMUST00000025223.8 NM_009995 uc008cdo.1 uc008cdo.2 uc008cdo.3 uc008cdo.4 Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc008cdo.1 uc008cdo.2 uc008cdo.3 uc008cdo.4 
ENSMUST00000025224.9 Gfra3 ENSMUST00000025224.9 glial cell line derived neurotrophic factor family receptor alpha 3 (from RefSeq NM_010280.4) ENSMUST00000025224.1 ENSMUST00000025224.2 ENSMUST00000025224.3 ENSMUST00000025224.4 ENSMUST00000025224.5 ENSMUST00000025224.6 ENSMUST00000025224.7 ENSMUST00000025224.8 GFRA3_MOUSE NM_010280 O35118 O35325 O55243 Q6NZC2 Q8C8L9 uc008ele.1 uc008ele.2 uc008ele.3 uc008ele.4 uc008ele.5 uc008ele.6 This gene encodes a cell surface glycoprotein and member of the glial cell line-derived neurotrophic receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein mediates binding of the ligand artemin to the ret receptor tyrosine kinase, and this interaction may regulate thermal pain and axon regeneration. Homozygous knockout mice for this gene exhibit impaired proliferation of cultured neuroblasts and impaired development of the superior cervical ganglion. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066202.1, AK046542.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Receptor for the glial cell line-derived neurotrophic factor, artemin. Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase (By similarity). Interacts with SORL1. Cell membrane ; Lipid-anchor, GPI- anchor Belongs to the GDNFR family. neuron migration protein binding cytosol plasma membrane transmembrane receptor protein tyrosine kinase signaling pathway nervous system development axon guidance axon guidance receptor activity external side of plasma membrane coreceptor activity membrane glial cell-derived neurotrophic factor receptor activity anchored component of membrane glial cell-derived neurotrophic factor receptor signaling pathway signaling receptor activity receptor complex sympathetic nervous system development neuron development uc008ele.1 uc008ele.2 uc008ele.3 uc008ele.4 uc008ele.5 uc008ele.6 
ENSMUST00000025229.11 Cfb ENSMUST00000025229.11 complement factor B, transcript variant 1 (from RefSeq NM_008198.3) B8JJM5 B8JJM5_MOUSE Cfb ENSMUST00000025229.1 ENSMUST00000025229.10 ENSMUST00000025229.2 ENSMUST00000025229.3 ENSMUST00000025229.4 ENSMUST00000025229.5 ENSMUST00000025229.6 ENSMUST00000025229.7 ENSMUST00000025229.8 ENSMUST00000025229.9 NM_008198 uc289khr.1 uc289khr.2 Reaction=Cleavage of Arg-|-Ser bond in complement component C3 alpha- chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b.; EC=3.4.21.47; Evidence=; Secreted Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase activity extracellular region proteolysis complement activation peptidase activity serine-type peptidase activity hydrolase activity uc289khr.1 uc289khr.2 
ENSMUST00000025230.15 C2 ENSMUST00000025230.15 complement C2 (from RefSeq NM_013484.2) CO2_MOUSE ENSMUST00000025230.1 ENSMUST00000025230.10 ENSMUST00000025230.11 ENSMUST00000025230.12 ENSMUST00000025230.13 ENSMUST00000025230.14 ENSMUST00000025230.2 ENSMUST00000025230.3 ENSMUST00000025230.4 ENSMUST00000025230.5 ENSMUST00000025230.6 ENSMUST00000025230.7 ENSMUST00000025230.8 ENSMUST00000025230.9 NM_013484 O70350 P21180 uc008cdz.1 uc008cdz.2 uc008cdz.3 uc008cdz.4 This gene encodes component C2 of the classical pathway of the complement system. The encoded protein undergoes proteolytic processing mediated by component C1 resulting in C2a and C2b fragments. C2a fragment, in turn, selectively cleaves components C3 and C5 of the complement system. Mice lacking the encoded protein are found to be more susceptible to bacterial infections. Mutations in the human homolog of this gene are associated with disorders such as systemic lupus erythematosus, Henoch-Schonlein purpura, or polymyositis. [provided by RefSeq, Mar 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146812.1, BC011086.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. Reaction=Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b.; EC=3.4.21.43; Secreted. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P21180-1; Sequence=Displayed; Name=Short; IsoId=P21180-2; Sequence=VSP_005385; The MIDAS-like motif in the VWFA domain binds divalent metal cations. C2 is a major histocompatibility complex class-III protein. Belongs to the peptidase S1 family. immune system process serine-type endopeptidase activity extracellular region extracellular space proteolysis complement activation complement activation, classical pathway response to nutrient peptidase activity serine-type peptidase activity hydrolase activity innate immune response metal ion binding positive regulation of apoptotic cell clearance uc008cdz.1 uc008cdz.2 uc008cdz.3 uc008cdz.4 
ENSMUST00000025234.7 Epb41l4a ENSMUST00000025234.7 erythrocyte membrane protein band 4.1 like 4a (from RefSeq NM_013512.2) E41LA_MOUSE ENSMUST00000025234.1 ENSMUST00000025234.2 ENSMUST00000025234.3 ENSMUST00000025234.4 ENSMUST00000025234.5 ENSMUST00000025234.6 Epb4.1l4 Epb4.1l4a Epb41l4 Epb41l4a NM_013512 P52963 Q91VX6 uc008ejz.1 uc008ejz.2 uc008ejz.3 Cytoplasm, cytoskeleton Brain, heart, lung, liver and spleen. Not detected in thymus and kidney. cytoplasm cytoskeleton cytoskeletal protein binding actomyosin structure organization uc008ejz.1 uc008ejz.2 uc008ejz.3 
ENSMUST00000025236.9 Stard4 ENSMUST00000025236.9 StAR related lipid transfer domain containing 4, transcript variant 1 (from RefSeq NM_133774.5) ENSMUST00000025236.1 ENSMUST00000025236.2 ENSMUST00000025236.3 ENSMUST00000025236.4 ENSMUST00000025236.5 ENSMUST00000025236.6 ENSMUST00000025236.7 ENSMUST00000025236.8 NM_133774 Q80SX0 Q80SX0_MOUSE Stard4 uc008ejr.1 uc008ejr.2 uc008ejr.3 cytoplasm lipid binding positive regulation of cholesterol esterification cholesterol transport involved in cholesterol storage cholesterol binding cytoplasmic vesicle intracellular cholesterol transport cholesterol import positive regulation of bile acid biosynthetic process uc008ejr.1 uc008ejr.2 uc008ejr.3 
ENSMUST00000025237.5 Tslp ENSMUST00000025237.5 thymic stromal lymphopoietin, transcript variant 1 (from RefSeq NM_021367.2) ENSMUST00000025237.1 ENSMUST00000025237.2 ENSMUST00000025237.3 ENSMUST00000025237.4 NM_021367 Q9JIE6 TSLP_MOUSE uc008ejl.1 uc008ejl.2 uc008ejl.3 uc008ejl.4 Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity). Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex. Q9JIE6; Q8CII9: Crlf2; NbExp=9; IntAct=EBI-16096402, EBI-15887886; Secreted positive regulation of cytokine-mediated signaling pathway cytokine activity interleukin-7 receptor binding protein binding extracellular region extracellular space signal transduction positive regulation of cell proliferation positive regulation of chemokine production positive regulation of interleukin-10 production positive regulation of interleukin-13 production positive regulation of interleukin-5 production positive regulation of interleukin-6 production positive regulation of mast cell activation positive regulation of tyrosine phosphorylation of STAT protein negative regulation of apoptotic process positive regulation of inflammatory response defense response to Gram-negative bacterium defense response to fungus positive regulation of chemokine (C-C motif) ligand 1 production positive regulation of granulocyte colony-stimulating factor production positive regulation of STAT cascade positive regulation of interleukin-5 secretion uc008ejl.1 uc008ejl.2 uc008ejl.3 uc008ejl.4 
ENSMUST00000025241.7 Ercc3 ENSMUST00000025241.7 excision repair cross-complementing rodent repair deficiency, complementation group 3 (from RefSeq NM_133658.2) ENSMUST00000025241.1 ENSMUST00000025241.2 ENSMUST00000025241.3 ENSMUST00000025241.4 ENSMUST00000025241.5 ENSMUST00000025241.6 ERCC3_MOUSE NM_133658 P49135 Xpb Xpbc uc008eje.1 uc008eje.2 uc008eje.3 ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP- dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK- activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with PUF60. Interacts with ATF7IP. Interacts with KAT2A; leading to KAT2A recruitment to promoters and acetylation of histones. Nucleus. Belongs to the helicase family. RAD25/XPB subfamily. nucleotide-excision repair factor 3 complex nucleotide binding core TFIIH complex nucleotide-excision repair, DNA duplex unwinding response to hypoxia DNA binding DNA helicase activity helicase activity protein kinase activity ATP binding nucleus nucleoplasm transcription factor TFIID complex holo TFIIH complex DNA topological change DNA repair transcription-coupled nucleotide-excision repair nucleotide-excision repair transcription elongation from RNA polymerase I promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter protein phosphorylation apoptotic process cellular response to DNA damage stimulus response to oxidative stress protein C-terminus binding DNA-dependent ATPase activity protein localization transcription factor binding RNA polymerase II carboxy-terminal domain kinase activity response to UV UV protection hydrolase activity ATPase activity nucleotide-excision repair, DNA incision hair cell differentiation positive regulation of apoptotic process 3'-5' DNA helicase activity positive regulation of transcription from RNA polymerase II promoter protein N-terminus binding embryonic organ development transcriptional preinitiation complex regulation of mitotic cell cycle phase transition uc008eje.1 uc008eje.2 uc008eje.3 
ENSMUST00000025243.5 Iws1 ENSMUST00000025243.5 IWS1, SUPT6 interacting protein (from RefSeq NM_173441.4) ENSMUST00000025243.1 ENSMUST00000025243.2 ENSMUST00000025243.3 ENSMUST00000025243.4 IWS1_MOUSE Iws1l NM_173441 Q3TQ25 Q3UWB0 Q6NVD1 Q8BY73 Q8C1D8 Q9D9H4 uc008eiy.1 uc008eiy.2 uc008eiy.3 uc008eiy.4 Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription (By similarity). Interacts with SUPT6H; binds preferentially to the POLR2A- bound SUPT6H. Interacts with ALYREF/THOC4, SETD2 and PRMT5 (By similarity). Interacts with HDGFRP2 (By similarity). Interacts (via IBM motif) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C1D8-1; Sequence=Displayed; Name=2; IsoId=Q8C1D8-2; Sequence=VSP_016994, VSP_016995; Ubiquitous. Expressed at highest level in kidney, then testicle, large intestine, small intestine, spleen and prostate, whereas the lowest level is detected in heart. Phosphorylation increases its interaction with PSIP1. Belongs to the IWS1 family. Sequence=BAB24793.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE23006.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleus nucleoplasm mRNA processing RNA splicing regulation of mRNA export from nucleus regulation of mRNA processing mRNA transport regulation of histone H4 acetylation regulation of histone H3-K36 trimethylation uc008eiy.1 uc008eiy.2 uc008eiy.3 uc008eiy.4 
ENSMUST00000025249.7 Apom ENSMUST00000025249.7 apolipoprotein M (from RefSeq NM_018816.2) APOM_MOUSE ENSMUST00000025249.1 ENSMUST00000025249.2 ENSMUST00000025249.3 ENSMUST00000025249.4 ENSMUST00000025249.5 ENSMUST00000025249.6 NM_018816 Ng20 Q9Z1R3 uc008cga.1 uc008cga.2 uc008cga.3 Probably involved in lipid transport. Can bind sphingosine-1- phosphate, myristic acid, palmitic acid and stearic acid, retinol, all- trans-retinoic acid and 9-cis-retinoic acid (By similarity). Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation. Secreted Expressed by the liver; secreted in plasma. Belongs to the calycin superfamily. Lipocalin family. Highly divergent. lipid transporter activity protein binding phospholipid binding extracellular region extracellular space lipid transport response to glucose antioxidant activity cholesterol efflux very-low-density lipoprotein particle low-density lipoprotein particle high-density lipoprotein particle discoidal high-density lipoprotein particle spherical high-density lipoprotein particle high-density lipoprotein particle remodeling high-density lipoprotein particle assembly high-density lipoprotein particle clearance negative regulation of plasma lipoprotein particle oxidation lipoprotein metabolic process reverse cholesterol transport cellular oxidant detoxification uc008cga.1 uc008cga.2 uc008cga.3 
ENSMUST00000025253.12 Prrc2a ENSMUST00000025253.12 proline-rich coiled-coil 2A, transcript variant 1 (from RefSeq NM_020027.3) Bat2 ENSMUST00000025253.1 ENSMUST00000025253.10 ENSMUST00000025253.11 ENSMUST00000025253.2 ENSMUST00000025253.3 ENSMUST00000025253.4 ENSMUST00000025253.5 ENSMUST00000025253.6 ENSMUST00000025253.7 ENSMUST00000025253.8 ENSMUST00000025253.9 NM_020027 PRC2A_MOUSE Q7TSC1 Q923A9 Q9Z1R1 uc008cgj.1 uc008cgj.2 uc008cgj.3 uc008cgj.4 uc008cgj.5 May play a role in the regulation of pre-mRNA splicing. Cytoplasm Nucleus nucleus nucleoplasm cytoplasm cytosol plasma membrane uc008cgj.1 uc008cgj.2 uc008cgj.3 uc008cgj.4 uc008cgj.5 
ENSMUST00000025254.9 Lims2 ENSMUST00000025254.9 LIM and senescent cell antigen like domains 2, transcript variant 1 (from RefSeq NM_144862.4) ENSMUST00000025254.1 ENSMUST00000025254.2 ENSMUST00000025254.3 ENSMUST00000025254.4 ENSMUST00000025254.5 ENSMUST00000025254.6 ENSMUST00000025254.7 ENSMUST00000025254.8 LIMS2_MOUSE NM_144862 Pinch2 Q91XD2 uc008eiv.1 uc008eiv.2 uc008eiv.3 Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS1. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA (By similarity). Interacts with TGFB1I1. Cell junction, focal adhesion Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Detected in heart, lung, kidney, liver, urinary bladder, fat, skin, skeletal muscle, uterus, large intestine and testis. Not detectable during early stages of embryogenesis. Detected at low levels at 14.5 dpc and 15.5 dpc. Highly expressed at 17.5 dpc. molecular_function cytoplasm plasma membrane cell-cell junction focal adhesion membrane cell junction negative regulation of apoptotic process cell-cell junction organization metal ion binding negative regulation of epithelial cell proliferation cell-cell adhesion positive regulation of substrate adhesion-dependent cell spreading negative regulation of neural precursor cell proliferation negative regulation of hepatocyte proliferation positive regulation of integrin-mediated signaling pathway uc008eiv.1 uc008eiv.2 uc008eiv.3 
ENSMUST00000025262.6 Ltb ENSMUST00000025262.6 lymphotoxin B (from RefSeq NM_008518.2) ENSMUST00000025262.1 ENSMUST00000025262.2 ENSMUST00000025262.3 ENSMUST00000025262.4 ENSMUST00000025262.5 NM_008518 P41155 TNFC_MOUSE Tnfc Tnfsf3 uc008cgp.1 uc008cgp.2 uc008cgp.3 uc008cgp.4 Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Membrane ; Single-pass type II membrane protein Belongs to the tumor necrosis factor family. cytokine activity tumor necrosis factor receptor binding extracellular space plasma membrane immune response signal transduction gene expression membrane integral component of membrane skin development positive regulation of interleukin-12 biosynthetic process lymph node development uc008cgp.1 uc008cgp.2 uc008cgp.3 uc008cgp.4 
ENSMUST00000025263.15 Tnf ENSMUST00000025263.15 tumor necrosis factor, transcript variant 1 (from RefSeq NM_013693.3) ENSMUST00000025263.1 ENSMUST00000025263.10 ENSMUST00000025263.11 ENSMUST00000025263.12 ENSMUST00000025263.13 ENSMUST00000025263.14 ENSMUST00000025263.2 ENSMUST00000025263.3 ENSMUST00000025263.4 ENSMUST00000025263.5 ENSMUST00000025263.6 ENSMUST00000025263.7 ENSMUST00000025263.8 ENSMUST00000025263.9 NM_013693 Q3U593 Q3U593_MOUSE TNFA Tnf uc008cgr.1 uc008cgr.2 uc008cgr.3 uc008cgr.4 This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. Homotrimer. Interacts with SPPL2B. Cell membrane ingle-pass type II membrane protein [C-domain 2]: Secreted [Tumor necrosis factor, soluble form]: Secreted [Tumor necrosis factor, membrane form]: Membrane ; Single-pass type II membrane protein [C-domain 1]: Secreted O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid. The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1. The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space. Belongs to the tumor necrosis factor family. negative regulation of transcription from RNA polymerase II promoter MAPK cascade activation of MAPKKK activity activation of MAPK activity positive regulation of cytokine production positive regulation of protein phosphorylation protease binding chronic inflammatory response to antigenic stimulus negative regulation of cytokine secretion involved in immune response cytokine activity tumor necrosis factor receptor binding extracellular region extracellular space integral component of plasma membrane activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response immune response extrinsic apoptotic signaling pathway via death domain receptors response to virus cell surface positive regulation of gene expression negative regulation of gene expression membrane integral component of membrane sequestering of triglyceride cortical actin cytoskeleton organization positive regulation of protein complex assembly lipopolysaccharide-mediated signaling pathway negative regulation of interleukin-6 production positive regulation of chemokine production positive regulation of interleukin-6 production positive regulation of interleukin-8 production receptor biosynthetic process positive regulation of peptidyl-serine phosphorylation tumor necrosis factor-mediated signaling pathway positive regulation of heterotypic cell-cell adhesion negative regulation of myosin-light-chain-phosphatase activity identical protein binding positive regulation of apoptotic process positive regulation of programmed cell death regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of protein complex disassembly positive regulation of protein complex disassembly positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAP kinase activity protein kinase B signaling positive regulation of JUN kinase activity transcription regulatory region DNA binding negative regulation of viral genome replication positive regulation of chemokine biosynthetic process membrane raft positive regulation of interleukin-8 biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of osteoclast differentiation positive regulation of protein catabolic process positive regulation of cell adhesion positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic digestive tract development positive regulation of smooth muscle cell proliferation positive regulation of cytokine secretion positive regulation of phagocytosis regulation of insulin secretion leukocyte tethering or rolling negative regulation of lipid catabolic process positive regulation of membrane protein ectodomain proteolysis positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of protein transport response to glucocorticoid positive regulation of glial cell proliferation positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1-monooxygenase activity negative regulation of branching involved in lung morphogenesis positive regulation of calcineurin-NFAT signaling cascade cellular response to nicotine cellular response to organic cyclic compound positive regulation of podosome assembly protein localization to plasma membrane extrinsic apoptotic signaling pathway necroptotic signaling pathway positive regulation of NIK/NF-kappaB signaling positive regulation of superoxide dismutase activity regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of leukocyte adhesion to arterial endothelial cell positive regulation of protein localization to cell surface positive regulation of blood microparticle formation positive regulation of chemokine (C-X-C motif) ligand 2 production regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc008cgr.1 uc008cgr.2 uc008cgr.3 uc008cgr.4 
ENSMUST00000025264.8 Wdr33 ENSMUST00000025264.8 WD repeat domain 33, transcript variant 1 (from RefSeq NM_028866.3) ENSMUST00000025264.1 ENSMUST00000025264.2 ENSMUST00000025264.3 ENSMUST00000025264.4 ENSMUST00000025264.5 ENSMUST00000025264.6 ENSMUST00000025264.7 NM_028866 Q8C7C6 Q8CD02 Q8K4P0 WDR33_MOUSE Wdc146 uc008eis.1 uc008eis.2 uc008eis.3 uc008eis.4 Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. Component of the cleavage and polyadenylation specificity factor (CPSF) module of the pre-mRNA 3'-end processing complex. Interacts with CPSF3/CPSF73 (By similarity). Nucleus Most highly expressed in testis. Belongs to the WD repeat WDR33 family. fibrillar center collagen trimer nucleus nucleoplasm mRNA cleavage and polyadenylation specificity factor complex mRNA polyadenylation mRNA processing uc008eis.1 uc008eis.2 uc008eis.3 uc008eis.4 
ENSMUST00000025266.6 Lta ENSMUST00000025266.6 lymphotoxin A (from RefSeq NM_010735.2) ENSMUST00000025266.1 ENSMUST00000025266.2 ENSMUST00000025266.3 ENSMUST00000025266.4 ENSMUST00000025266.5 Lta NM_010735 Q542S2 Q542S2_MOUSE Tnlg1e uc008cgu.1 uc008cgu.2 uc008cgu.3 Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14. Secreted Membrane Belongs to the tumor necrosis factor family. response to hypoxia cytokine activity tumor necrosis factor receptor binding extracellular region extracellular space immune response signal transduction response to nutrient membrane response to lipopolysaccharide response to drug positive regulation of apoptotic process negative regulation of fibroblast proliferation positive regulation of glial cell proliferation uc008cgu.1 uc008cgu.2 uc008cgu.3 
ENSMUST00000025270.8 Riok3 ENSMUST00000025270.8 RIO kinase 3 (from RefSeq NM_024182.4) ENSMUST00000025270.1 ENSMUST00000025270.2 ENSMUST00000025270.3 ENSMUST00000025270.4 ENSMUST00000025270.5 ENSMUST00000025270.6 ENSMUST00000025270.7 NM_024182 Q3UI51 Q8CIC1 Q9DBU3 RIOK3_MOUSE uc008eby.1 uc008eby.2 uc008eby.3 Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7- mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with CASP10. Interacts with IRF3; RIOK3 probably mediates the interaction of TBK1 with IRF3. Associated with 40S pre- ribosomal particles. Cytoplasm Autophosphorylated (in vitro). Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. nucleotide binding immune system process protein serine/threonine kinase activity ATP binding cytoplasm cytosol protein phosphorylation kinase activity phosphorylation transferase activity maturation of SSU-rRNA preribosome, small subunit precursor negative regulation of protein homooligomerization positive regulation of interferon-beta production negative regulation of MDA-5 signaling pathway ribosome biogenesis negative regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of innate immune response metal ion binding defense response to virus cellular response to dsRNA caspase binding cellular response to virus cellular response to dsDNA uc008eby.1 uc008eby.2 uc008eby.3 
ENSMUST00000025271.17 Pou5f1 ENSMUST00000025271.17 POU domain, class 5, transcription factor 1, transcript variant 1 (from RefSeq NM_013633.3) ENSMUST00000025271.1 ENSMUST00000025271.10 ENSMUST00000025271.11 ENSMUST00000025271.12 ENSMUST00000025271.13 ENSMUST00000025271.14 ENSMUST00000025271.15 ENSMUST00000025271.16 ENSMUST00000025271.2 ENSMUST00000025271.3 ENSMUST00000025271.4 ENSMUST00000025271.5 ENSMUST00000025271.6 ENSMUST00000025271.7 ENSMUST00000025271.8 ENSMUST00000025271.9 NM_013633 Oct-3 Oct-4 Otf-3 Otf3 P20263 PO5F1_MOUSE Q63843 uc008chu.1 uc008chu.2 uc008chu.3 uc008chu.4 The protein encoded by this gene belongs to the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein plays a key role in embryonic development and stem cell pluripotency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') (PubMed:1972777, PubMed:1690859, PubMed:1967980, PubMed:17525163, PubMed:23376973). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:17496161, PubMed:19740739). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:1972777, PubMed:1690859, PubMed:17496161, PubMed:18662995, PubMed:19740739, PubMed:29153991, PubMed:23376973, PubMed:32703285). Interacts with PKM. Interacts with WWP2 (By similarity). Interacts with UBE2I and ZSCAN10 (PubMed:17496161, PubMed:19740739). Interacts with PCGF1 (By similarity). Interacts with ESRRB; recruits ESRRB near the POU5F1-SOX2 element in the NANOG proximal promoter; the interaction is DNA independent (PubMed:18662995). Interacts with ZNF322 (PubMed:24550733). Interacts with MAPK8 and MAPK9; the interaction allows MAPK8 and MAPK9 to phosphorylate POU5F1 on Ser-347 (PubMed:29153991). Interacts (when phosphorylated on Ser-347) with FBXW8 (PubMed:29153991). Interacts with FBXW4 (PubMed:29153991). Interacts with SOX2 and SOX15; binds synergistically with either SOX2 or SOX15 to DNA (PubMed:15863505). Interacts with DDX56 (PubMed:32703285). P20263; P11440: Cdk1; NbExp=4; IntAct=EBI-1606219, EBI-846949; P20263; Q61545: Ewsr1; NbExp=13; IntAct=EBI-1606219, EBI-1606991; P20263; Q9R190: Mta2; NbExp=6; IntAct=EBI-1606219, EBI-904134; P20263; Q80Z64: Nanog; NbExp=4; IntAct=EBI-1606219, EBI-2312517; P20263; Q61066: Nr0b1; NbExp=5; IntAct=EBI-1606219, EBI-2312665; P20263; P11103: Parp1; NbExp=2; IntAct=EBI-1606219, EBI-642213; P20263; P52480: Pkm; NbExp=6; IntAct=EBI-1606219, EBI-647785; P20263; Q8BUN5: Smad3; NbExp=13; IntAct=EBI-1606219, EBI-2337983; P20263; P48432: Sox2; NbExp=4; IntAct=EBI-1606219, EBI-2313612; P20263; Q62318-1: Trim28; NbExp=3; IntAct=EBI-1606219, EBI-6876996; P20263; P61965: Wdr5; NbExp=7; IntAct=EBI-1606219, EBI-1247084; Cytoplasm Nucleus Note=Expressed in a diffuse and slightly punctuate pattern (By similarity). Colocalizes with MAPK8 and MAPK9 in the nucleus (PubMed:29153991). Expressed the totipotent and pluripotent stem cells of the pregastrulation embryo. Also expressed in primordial germ cells and in the female germ line. Absent from adult tissues. Down-regulated during differentiation to endoderm and mesoderm. Repressed by retinoic acid (RA). The POU-specific domain mediates interaction with PKM. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression. Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation. ERK1/2-mediated phosphorylation at Ser-106 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-228 and Ser-229 decrease DNA-binding and alters ability to activate transcription (By similarity). JNK1/2-mediated phosphorylation at Ser- 347 promotes proteasomal degradation (PubMed:29153991). POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Belongs to the POU transcription factor family. Class-5 subfamily. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding enhancer sequence-specific DNA binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding mesodermal cell fate commitment endodermal cell fate commitment ectodermal cell fate commitment endodermal cell fate specification blastocyst development trophectodermal cell differentiation blastocyst growth BMP signaling pathway involved in heart induction DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm transcription factor complex nucleolus cytoplasm mitochondrion cytosol regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development transcription factor binding regulation of asymmetric cell division response to organic substance regulation of gene expression positive regulation of gene expression negative regulation of gene expression transcriptional repressor complex stem cell population maintenance cytokine binding germ-line stem cell population maintenance chromatin DNA binding ubiquitin protein ligase binding response to retinoic acid response to cytokine somatic stem cell population maintenance miRNA binding mRNA transcription from RNA polymerase II promoter sequence-specific DNA binding transcription regulatory region DNA binding nuclear transcription factor complex cell fate commitment negative regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of calcium ion-dependent exocytosis stem cell differentiation negative regulation of protein kinase B signaling positive regulation of SMAD protein import into nucleus cell fate commitment involved in formation of primary germ layer cardiac cell fate determination negative regulation of gene silencing by miRNA POU domain binding HMG box domain binding regulation of heart induction by regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of methylation-dependent chromatin silencing cellular response to leukemia inhibitory factor uc008chu.1 uc008chu.2 uc008chu.3 uc008chu.4 
ENSMUST00000025273.9 Psors1c2 ENSMUST00000025273.9 psoriasis susceptibility 1 candidate 2 (human) (from RefSeq NM_020576.2) ENSMUST00000025273.1 ENSMUST00000025273.2 ENSMUST00000025273.3 ENSMUST00000025273.4 ENSMUST00000025273.5 ENSMUST00000025273.6 ENSMUST00000025273.7 ENSMUST00000025273.8 NM_020576 Psors1c2 Q3UUY0 Q3UUY0_MOUSE uc008chz.1 uc008chz.2 uc008chz.3 uc008chz.4 uc008chz.5 uc008chz.1 uc008chz.2 uc008chz.3 uc008chz.4 uc008chz.5 
ENSMUST00000025276.15 Rmc1 ENSMUST00000025276.15 regulator of MON1-CCZ1 (from RefSeq NM_029623.2) ENSMUST00000025276.1 ENSMUST00000025276.10 ENSMUST00000025276.11 ENSMUST00000025276.12 ENSMUST00000025276.13 ENSMUST00000025276.14 ENSMUST00000025276.2 ENSMUST00000025276.3 ENSMUST00000025276.4 ENSMUST00000025276.5 ENSMUST00000025276.6 ENSMUST00000025276.7 ENSMUST00000025276.8 ENSMUST00000025276.9 Mic1 NM_029623 O35606 Q8VC42 RMC1_MOUSE Wdr98 uc008eca.1 uc008eca.2 uc008eca.3 uc008eca.4 Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization. Found in a complex with RMC1, CCZ1, MON1A and MON1B. Lysosome membrane Late endosome membrane Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Belongs to the RMC1 family. Sequence=AAB63375.1; Type=Erroneous initiation; Evidence=; lysosome lysosomal membrane endosome autophagy regulation of autophagy membrane late endosome membrane Mon1-Ccz1 complex uc008eca.1 uc008eca.2 uc008eca.3 uc008eca.4 
ENSMUST00000025278.8 Mrpl27 ENSMUST00000025278.8 mitochondrial ribosomal protein L27 (from RefSeq NM_053161.2) ENSMUST00000025278.1 ENSMUST00000025278.2 ENSMUST00000025278.3 ENSMUST00000025278.4 ENSMUST00000025278.5 ENSMUST00000025278.6 ENSMUST00000025278.7 NM_053161 Q99N92 RM27_MOUSE uc007kzg.1 uc007kzg.2 uc007kzg.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the bacterial ribosomal protein bL27 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation uc007kzg.1 uc007kzg.2 uc007kzg.3 
ENSMUST00000025279.6 Npc1 ENSMUST00000025279.6 NPC intracellular cholesterol transporter 1 (from RefSeq NM_008720.2) ENSMUST00000025279.1 ENSMUST00000025279.2 ENSMUST00000025279.3 ENSMUST00000025279.4 ENSMUST00000025279.5 G3X8W9 NM_008720 NPC1_MOUSE Npc1 O35604 O35605 uc008ecb.1 uc008ecb.2 uc008ecb.3 Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:21896731, PubMed:22048958, PubMed:27551080). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (By similarity). May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9 (By similarity). Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747, ChEBI:CHEBI:16113; Evidence=; Interacts (via the second lumenal domain) with NPC2 (PubMed:22065762, PubMed:27551080). Interacts with TMEM97. Interacts with TIM1 (By similarity). Interacts with SLC38A9; this interaction inhibits cholesterol-mediated mTORC1 activation via its sterol transport activity (By similarity). O35604; A0A0F6B1Q8: sseJ; Xeno; NbExp=3; IntAct=EBI-13641434, EBI-10760263; Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ulti-pass membrane protein Detected in liver (at protein level) (PubMed:21896731, PubMed:22048958). Ubiquitous (PubMed:9211850). Detected in adult heart, spleen, lung, liver, skeletal muscle, kidney, testis (PubMed:9211850). A cysteine-rich N-terminal domain and a C-terminal domain containing a di-leucine motif necessary for lysosomal targeting are critical for mobilization of cholesterol from lysosomes. N-glycosylated. Note=Defects in Npc1 cause a lysosomal storage disorder characterized by accumulation of cholesterol in lysosomes and impaired cholesterol homeostasis. Causes age-dependent loss of Purkinje cells, loss of body weight and leads then to ataxia and premature death at a median age of 72 days. Belongs to the patched family. lipid transporter activity protein binding extracellular region nuclear envelope lysosome lysosomal membrane endosome endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane protein glycosylation lipid metabolic process lipid transport endocytosis autophagy lysosomal transport adult walking behavior steroid metabolic process cholesterol metabolic process bile acid metabolic process cholesterol binding membrane integral component of membrane negative regulation of macroautophagy cholesterol transport membrane raft organization late endosome membrane vesicle intracellular cholesterol transport cholesterol efflux response to drug cholesterol homeostasis membrane raft response to cadmium ion viral entry into host cell perinuclear region of cytoplasm negative regulation of cell death cellular response to steroid hormone stimulus cellular response to low-density lipoprotein particle stimulus establishment of protein localization to membrane integral component of lysosomal membrane uc008ecb.1 uc008ecb.2 uc008ecb.3 
ENSMUST00000025288.9 Zfp521 ENSMUST00000025288.9 zinc finger protein 521, transcript variant 1 (from RefSeq NM_145492.4) ENSMUST00000025288.1 ENSMUST00000025288.2 ENSMUST00000025288.3 ENSMUST00000025288.4 ENSMUST00000025288.5 ENSMUST00000025288.6 ENSMUST00000025288.7 ENSMUST00000025288.8 Evi3 NM_145492 Q6KAS7 Q8BIF5 Q8BV21 Q8CIQ2 Q8VDS6 ZN521_MOUSE Znf521 uc008edd.1 uc008edd.2 uc008edd.3 uc008edd.4 uc008edd.5 Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. Interacts with EBF1. Interacts with SMAD1 and SMAD4 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6KAS7-1; Sequence=Displayed; Name=2; IsoId=Q6KAS7-2; Sequence=VSP_028553; Widely expressed. Expressed in all B-cell stages. Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and hematopoietic system. Note=Defects in Znf521 are a cause of B-cell lymphomas. The Znf521 gene is a frequent target of retroviral integration in murine B- cell lymphomas. Involved in most B-cell tumors in the AKXD-27 strain. Viral insertion into the Znf521 gene in the AKXD-27 strain causes Znf521 overexpression in B-cell tumors, resulting in the up-regulation of EBF1 and the increased expression of a number of EBF1 target genes. This in contrast to the role of Znf521 in other cells as a transcriptional repressor of EBF1. Misexpression initiates tumorigenesis by perturbing B-cell development via an interaction with EBF1. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC36964.1; Type=Erroneous initiation; Evidence=; Sequence=BAD21380.1; Type=Erroneous initiation; Evidence=; RNA polymerase II core promoter sequence-specific DNA binding nucleic acid binding DNA binding nucleus nucleoplasm multicellular organism development regulation of gene expression protein domain specific binding cell differentiation metal ion binding neuron fate commitment histone methyltransferase complex uc008edd.1 uc008edd.2 uc008edd.3 uc008edd.4 uc008edd.5 
ENSMUST00000025290.7 Impact ENSMUST00000025290.7 impact, RWD domain protein, transcript variant 1 (from RefSeq NM_008378.3) ENSMUST00000025290.1 ENSMUST00000025290.2 ENSMUST00000025290.3 ENSMUST00000025290.4 ENSMUST00000025290.5 ENSMUST00000025290.6 IMPCT_MOUSE NM_008378 O55091 Q3UUR6 Q9EQH0 uc008eda.1 uc008eda.2 uc008eda.3 Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis (PubMed:15937339, PubMed:23447528, PubMed:24333428). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (PubMed:15937339, PubMed:23447528). Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth (PubMed:23447528). Interacts with GCN1; prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity (PubMed:15937339, PubMed:22404850). Interaction with RPL39; this interaction occurs in a GCN1-independent manner (PubMed:22404850). Associates with ribosomes; this interaction occurs in a GCN1- independent manner (PubMed:22404850). Associates with actin; this interaction occurs in a GCN1-independent manner (PubMed:22404850). Cytoplasm Present in neurons in most areas of the brain. Present at high level in hypothalamus, particularly in the suprachiasmatic nucleus (at protein level) (PubMed:15937339, PubMed:18260151). Preferentially expressed in brain, with a weaker expression in other tissues (PubMed:9256468). Detected in embryos at 7, 11, 15, and 17 dpc. At 16 dpc, predominantly expressed in the central nervous system (at protein level). Strongly up-regulated during brain development from 17 dpc up to at least postnatal days 14 (at protein level). In N2a neuroblastoma cell line model and in primary cultures of hippocampal neurons, up-regulated during neuronal differentiation induced by serum reduction (at protein level). Up-regulated after serum withdrawal during neuronal differentiation (PubMed:23447528). The Impact locus is imprinted. Paternal inherited gene is expressed, while the maternal inherited gene is silenced. In contrast with most imprinted genes, neighboring genes are apparently not imprinted. Belongs to the IMPACT family. negative regulation of transcription from RNA polymerase II promoter negative regulation of protein phosphorylation actin binding protein binding cytoplasm polysome regulation of translation regulation of translational initiation nervous system development cell differentiation negative regulation of protein complex assembly negative regulation of protein autophosphorylation cellular response to amino acid starvation cellular response to glucose starvation ribosome binding positive regulation of neuron differentiation negative regulation of cell death regulation of eIF2 alpha phosphorylation by amino acid starvation cellular response to hydrogen peroxide positive regulation of translational initiation in response to starvation cellular response to acidic pH cellular response to UV-C cellular response to benomyl negative regulation of transcription from RNA polymerase II promoter in response to stress neuron projection extension cellular response to leucine starvation uc008eda.1 uc008eda.2 uc008eda.3 
ENSMUST00000025292.15 Dhx16 ENSMUST00000025292.15 DEAH-box helicase 16 (from RefSeq NM_026987.2) Dhx16 ENSMUST00000025292.1 ENSMUST00000025292.10 ENSMUST00000025292.11 ENSMUST00000025292.12 ENSMUST00000025292.13 ENSMUST00000025292.14 ENSMUST00000025292.2 ENSMUST00000025292.3 ENSMUST00000025292.4 ENSMUST00000025292.5 ENSMUST00000025292.6 ENSMUST00000025292.7 ENSMUST00000025292.8 ENSMUST00000025292.9 G3X8X0 G3X8X0_MOUSE NM_026987 uc008ciw.1 uc008ciw.2 uc008ciw.3 uc008ciw.4 uc008ciw.5 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; nucleotide binding mRNA splicing, via spliceosome nucleic acid binding RNA binding helicase activity ATP binding nucleus nucleoplasm spliceosomal complex hydrolase activity ATPase activity U2-type precatalytic spliceosome uc008ciw.1 uc008ciw.2 uc008ciw.3 uc008ciw.4 uc008ciw.5 
ENSMUST00000025295.8 Spry4 ENSMUST00000025295.8 sprouty RTK signaling antagonist 4 (from RefSeq NM_011898.3) ENSMUST00000025295.1 ENSMUST00000025295.2 ENSMUST00000025295.3 ENSMUST00000025295.4 ENSMUST00000025295.5 ENSMUST00000025295.6 ENSMUST00000025295.7 NM_011898 Q543R1 Q9QXV7 Q9WTP2 SPY4_MOUSE uc008esl.1 uc008esl.2 uc008esl.3 uc008esl.4 Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras (By similarity). Inhibits Ras-independent, but not Ras- dependent, activation of RAF1 (By similarity). Represses integrin- mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (By similarity). Interacts (via C-terminus) with TESK1 (via both C- and N- termini); the interaction inhibits TESK1 kinase activity (PubMed:17974561). Interacts with RAF1 (By similarity). Interacts with CAV1 (via C-terminus) (PubMed:16877379). Cytoplasm Cell projection, ruffle membrane ; Peripheral membrane protein Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). Colocalizes with TESK1 in vesicular spots in the cytoplasm (By similarity). Expressed in the embryo and adult tissues including heart, brain, lung, kidney, and skeletal muscle. At 8 dpc expressed in the lateral plate mesoderm of the primitive streak. At 9.5 and 10.5 dpc expressed in the nasal placodes, maxillary and mandibular processes, posterior part of the hyoid arch and the progress zone of the limb buds and the presomitic mesoderm. At 11.5 dpc expressed in the dorso-lateral region of the somites (mostly in the myotome) and in the otic vesicle. At 11.5 and 12.5 dpc expressed in the distal lung mesenchyme, with a strong expression in the accessory lobe of the lung. By FGF signaling. The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles. Belongs to the sprouty family. protein binding cytoplasm cytosol multicellular organism development regulation of signal transduction membrane negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of MAP kinase activity negative regulation of Ras protein signal transduction negative regulation of ERK1 and ERK2 cascade cellular response to leukemia inhibitory factor uc008esl.1 uc008esl.2 uc008esl.3 uc008esl.4 
ENSMUST00000025305.16 Mrps18b ENSMUST00000025305.16 mitochondrial ribosomal protein S18B, transcript variant 1 (from RefSeq NM_025878.2) ENSMUST00000025305.1 ENSMUST00000025305.10 ENSMUST00000025305.11 ENSMUST00000025305.12 ENSMUST00000025305.13 ENSMUST00000025305.14 ENSMUST00000025305.15 ENSMUST00000025305.2 ENSMUST00000025305.3 ENSMUST00000025305.4 ENSMUST00000025305.5 ENSMUST00000025305.6 ENSMUST00000025305.7 ENSMUST00000025305.8 ENSMUST00000025305.9 NM_025878 Q3TLA9 Q99N84 Q9CRK0 Q9DCR8 RT18B_MOUSE uc008cjg.1 uc008cjg.2 uc008cjg.3 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99N84-1; Sequence=Displayed; Name=2; IsoId=Q99N84-2; Sequence=VSP_005723; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily. Sequence=AK010250; Type=Frameshift; Evidence=; structural constituent of ribosome nucleoplasm mitochondrion mitochondrial small ribosomal subunit ribosome translation cell junction mitochondrial translation uc008cjg.1 uc008cjg.2 uc008cjg.3 
ENSMUST00000025311.8 Pcdh12 ENSMUST00000025311.8 protocadherin 12 (from RefSeq NM_017378.2) ENSMUST00000025311.1 ENSMUST00000025311.2 ENSMUST00000025311.3 ENSMUST00000025311.4 ENSMUST00000025311.5 ENSMUST00000025311.6 ENSMUST00000025311.7 G5E847 NM_017378 O55134 PCD12_MOUSE Pcdh12 uc008esb.1 uc008esb.2 uc008esb.3 uc008esb.4 Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (PubMed:9651350). Acts as a regulator of cell migration, probably via increasing cell- cell adhesion (By similarity). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (PubMed:9651350). Unable to bind to catenins, weakly associates with the cytoskeleton (PubMed:9651350). [Protocadherin-12]: Cell membrane ; Single-pass type I membrane protein Cell junction [Protocadherin-12, secreted form]: Secreted Note=The secreted form is produced following cleavage by ADAM10. Expressed in endothelial cells: localizes in vasculogenic rather than angiogenic endothelium (PubMed:9651350, PubMed:15541725). Strongly expressed in a subset of invasive cells of the placenta, named glycogen-rich trophoblasts cells (at protein level) (PubMed:15541725). glycogen-rich trophoblasts cells originate from the from the ectoplacental cone where they rapidly form tight islets (at protein level) (PubMed:16269175). In adult mice, present at high level in mesangial cells of kidney glomeruli, while expression was not detected in other types of perivascular cells (PubMed:15541725). N-glycosylated. [Protocadherin-12]: Cleaved by ADAM10 close to the transmembrane domain to release the Protocadherin-12, secreted form in the serum. Cleavage results in reduced cellular adhesion in a cell migration assay. Mice are viable and fertile (PubMed:15541725, PubMed:18477666). Mice however show alterations in placental development that result in embryonic growth retardation: placentas are smaller and show limited angiogenesis and mis-segregation of the labyrinthine and intermediate layers (PubMed:18477666). Mice also display modifications in the structure and function of arteries, such as rearrangement of the arterial wall elastic fibers (PubMed:22205043). calcium ion binding extracellular region plasma membrane integral component of plasma membrane cell-cell junction glycogen metabolic process cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell junction labyrinthine layer development uc008esb.1 uc008esb.2 uc008esb.3 uc008esb.4 
ENSMUST00000025314.7 Dele1 ENSMUST00000025314.7 DAP3 binding cell death enhancer 1 (from RefSeq NM_024179.5) DELE1_MOUSE Dele Dele1 ENSMUST00000025314.1 ENSMUST00000025314.2 ENSMUST00000025314.3 ENSMUST00000025314.4 ENSMUST00000025314.5 ENSMUST00000025314.6 Kiaa0141 NM_024179 Q6A0B8 Q9DCV6 uc008erz.1 uc008erz.2 uc008erz.3 uc008erz.4 Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency and mitochondrial stress. Detects impaired protein import and processing in mitochondria, activating the ISR. May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation. [DAP3-binding cell death enhancer 1]: Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR. [DAP3-binding cell death enhancer 1 short form]: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI. It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR. Interacts with DAP3. [DAP3-binding cell death enhancer 1]: Interacts (via TPR repeats) with EIF2AK1/HRI; activating the protein kinase activity of EIF2AK1/HRI, thereby promoting the integrated stress response (ISR). [DAP3-binding cell death enhancer 1 short form]: Interacts (via TPR repeats) with EIF2AK1/HRI; activating the protein kinase activity of EIF2AK1/HRI, thereby promoting the integrated stress response (ISR). [DAP3-binding cell death enhancer 1]: Mitochondrion Mitochondrion outer membrane Mitochondrion inner membrane Note=Imported in the mitochondrial matrix in absence of stress, leading to its degradation by LONP1. Localizes at the mitochondrial surface in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting localization at the mitochondrial surface and stabilization. Associates with the mitochondrion inner membrane in response to mitochondrial stress, leading to its proteolytic processing by OMA1, and generation of the AP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1). [DAP3-binding cell death enhancer 1 short form]: Cytoplasm, cytosol Note=This short form is generated by proteolytic processing by OMA1 in response to mitochondrial stress, leading to translocation to the cytosol. The TPR repeats bind to and activate EIF2AK1/HRI. [DAP3-binding cell death enhancer 1]: Unstable protein in absence of stress: imported in the mitochondrial matrix following processing by the mitochondrial-processing peptidase (MPP), where it is degraded by LONP1. Stabilized in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting localization at the mitochondrial surface and stabilization. Cleaved by OMA1 in response to mitochondrial stress, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1) that accumulates in the cytosol and activates the protein kinase activity of EIF2AK1/HRI. Protein cleavage by OMA1 can take place at different positions, and apparently does not require a specific sequence motif. Belongs to the DELE1 family. Sequence=BAD32178.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function mitochondrion extrinsic apoptotic signaling pathway via death domain receptors regulation of cysteine-type endopeptidase activity involved in apoptotic process uc008erz.1 uc008erz.2 uc008erz.3 uc008erz.4 
ENSMUST00000025319.7 Rpp21 ENSMUST00000025319.7 ribonuclease P 21 subunit (from RefSeq NM_026308.2) Cat60 ENSMUST00000025319.1 ENSMUST00000025319.2 ENSMUST00000025319.3 ENSMUST00000025319.4 ENSMUST00000025319.5 ENSMUST00000025319.6 NM_026308 Q80XY3 Q811B7 Q8R040 Q9CPX1 RPP21_MOUSE uc008ckq.1 uc008ckq.2 uc008ckq.3 Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Nucleus, nucleolus Belongs to the eukaryotic/archaeal RNase P protein component 4 family. tRNA 5'-leader removal ribonuclease P activity nucleus nucleolar ribonuclease P complex nucleolus tRNA processing hydrolase activity multimeric ribonuclease P complex ribonuclease P RNA binding response to drug metal ion binding RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc008ckq.1 uc008ckq.2 uc008ckq.3 
ENSMUST00000025322.14 H2-M10.1 ENSMUST00000025322.14 histocompatibility 2, M region locus 10.1, transcript variant 1 (from RefSeq NM_013544.3) ENSMUST00000025322.1 ENSMUST00000025322.10 ENSMUST00000025322.11 ENSMUST00000025322.12 ENSMUST00000025322.13 ENSMUST00000025322.2 ENSMUST00000025322.3 ENSMUST00000025322.4 ENSMUST00000025322.5 ENSMUST00000025322.6 ENSMUST00000025322.7 ENSMUST00000025322.8 ENSMUST00000025322.9 H2-M10.1 M10 NM_013544 O19443 O19443_MOUSE uc008cky.1 uc008cky.2 uc008cky.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc008cky.1 uc008cky.2 uc008cky.3 
ENSMUST00000025329.13 Trim15 ENSMUST00000025329.13 tripartite motif-containing 15, transcript variant 2 (from RefSeq NM_001024134.2) ENSMUST00000025329.1 ENSMUST00000025329.10 ENSMUST00000025329.11 ENSMUST00000025329.12 ENSMUST00000025329.2 ENSMUST00000025329.3 ENSMUST00000025329.4 ENSMUST00000025329.5 ENSMUST00000025329.6 ENSMUST00000025329.7 ENSMUST00000025329.8 ENSMUST00000025329.9 NM_001024134 Q8R096 Q8R096_MOUSE Trim15 uc008cli.1 uc008cli.2 uc008cli.3 uc008cli.4 molecular_function cellular_component zinc ion binding positive regulation of type I interferon production innate immune response metal ion binding positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of RIG-I signaling pathway negative regulation of intracellular transport of viral material negative regulation of viral release from host cell uc008cli.1 uc008cli.2 uc008cli.3 uc008cli.4 
ENSMUST00000025338.16 Gabbr1 ENSMUST00000025338.16 gamma-aminobutyric acid type B receptor subunit 1, transcript variant 1 (from RefSeq NM_019439.4) ENSMUST00000025338.1 ENSMUST00000025338.10 ENSMUST00000025338.11 ENSMUST00000025338.12 ENSMUST00000025338.13 ENSMUST00000025338.14 ENSMUST00000025338.15 ENSMUST00000025338.2 ENSMUST00000025338.3 ENSMUST00000025338.4 ENSMUST00000025338.5 ENSMUST00000025338.6 ENSMUST00000025338.7 ENSMUST00000025338.8 ENSMUST00000025338.9 GABR1_MOUSE NM_019439 Q6PGJ2 Q9WU48 Q9WV15 Q9WV16 Q9WV17 Q9WV18 uc008cma.1 uc008cma.2 uc008cma.3 Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:10773016, PubMed:10075644). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10773016, PubMed:10075644). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity). Pre- synaptic GABA receptor inhibits neurotransmitter release by down- regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity). Heterodimer of GABBR1 and GABBR2 (PubMed:10773016, PubMed:10075644, PubMed:9872744). Homodimers may form, but are inactive (By similarity). Interacts (via C-terminus) with ATF4 (via leucine zipper domain) (By similarity). Interacts with JAKMIP1 (PubMed:14718537). Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi- pass membrane protein Cell projection, dendrite Note=Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1A; IsoId=Q9WV18-1; Sequence=Displayed; Name=1B; IsoId=Q9WV18-2; Sequence=VSP_002041; Expressed in neuronal tissue including cortex, cerebellum and spinal cord. Not detected in non-neuronal tissues including heart, liver, spleen and kidney. Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABBR2. The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably plays a role in the specificity for G-protein coupling. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. osteoblast differentiation G-protein coupled receptor activity G-protein coupled GABA receptor activity protein binding extracellular space cytoplasm endoplasmic reticulum membrane plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity gamma-aminobutyric acid signaling pathway synaptic vesicle transcription factor binding negative regulation of cell proliferation regulation of glutamate secretion positive regulation of glutamate secretion negative regulation of gamma-aminobutyric acid secretion membrane integral component of membrane cell junction dendrite axolemma mitochondrial membrane negative regulation of epinephrine secretion negative regulation of dopamine secretion G-protein coupled receptor dimeric complex G-protein coupled receptor heterodimeric complex presynaptic membrane cell projection neuron projection neuronal cell body dendritic spine dendritic shaft intracellular membrane-bounded organelle membrane raft synapse postsynaptic membrane protein heterodimerization activity negative regulation of synaptic transmission regulation of postsynaptic membrane potential positive regulation of growth hormone secretion synaptic membrane presynapse glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential GABA receptor complex extracellular matrix protein binding uc008cma.1 uc008cma.2 uc008cma.3 
ENSMUST00000025350.10 Dcp2 ENSMUST00000025350.10 decapping mRNA 2 (from RefSeq NM_027490.1) DCP2_MOUSE ENSMUST00000025350.1 ENSMUST00000025350.2 ENSMUST00000025350.3 ENSMUST00000025350.4 ENSMUST00000025350.5 ENSMUST00000025350.6 ENSMUST00000025350.7 ENSMUST00000025350.8 ENSMUST00000025350.9 NM_027490 Q3TLD9 Q9CYC6 uc008eux.1 uc008eux.2 uc008eux.3 uc008eux.4 Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:21070968). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (By similarity). Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O- dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (By similarity). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (By similarity). Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP; Xref=Rhea:RHEA:67484, Rhea:RHEA-COMP:15692, Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:63714, ChEBI:CHEBI:138282, ChEBI:CHEBI:156461; EC=3.6.1.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67485; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Mn(2+) ion is required for highest activity. Can also utilize magnesium ions. ; Found in a mRNA decay complex with LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CNOT6, UPF1, UPF2 and UPF3B. Forms a complex with DCP1A, EDC3, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC4/HEDLS. Interacts with DPC1B, UPF1, UPF2 and UPF3B. Associates with polysomes. Interacts (via N-terminus and C- terminus) with TRIM21 (via N-terminus and C-terminus). Interacts with LIMD1, WTIP and AJUBA. Interacts with DDX17 in an RNA-dependent manner. Interacts with ZC3HAV1. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with ZFP36L1 (via N-terminus). Interacts with NBDY. Cytoplasm, P-body Nucleus Note=Predominantly cytoplasmic, in processing bodies (PB) (By similarity). A minor amount is nuclear (By similarity). Strongly expressed in brain and testis. Weakly expressed in lung. Not detected in heart, liver, kidney and muscle (at protein level). Strongly expressed in brain, heart, liver at 14.5 and 16.5 dpc. Strongly expressed in brain at 20 dpc. Weakly expressed in heart and liver at 20 dpc (at protein level). Belongs to the Nudix hydrolase family. DCP2 subfamily. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay deadenylation-dependent decapping of nuclear-transcribed mRNA P-body RNA binding 5'-3' exoribonuclease activity nucleus nucleoplasm cytoplasm mRNA catabolic process RISC complex hydrolase activity cell junction manganese ion binding negative regulation of telomere maintenance via telomerase cytoplasmic ribonucleoprotein granule regulation of mRNA stability metal ion binding m7G(5')pppN diphosphatase activity histone mRNA catabolic process RNA phosphodiester bond hydrolysis, exonucleolytic regulation of telomerase RNA localization to Cajal body uc008eux.1 uc008eux.2 uc008eux.3 uc008eux.4 
ENSMUST00000025356.4 Mal2 ENSMUST00000025356.4 mal, T cell differentiation protein 2 (from RefSeq NM_178920.4) ENSMUST00000025356.1 ENSMUST00000025356.2 ENSMUST00000025356.3 MAL2_MOUSE NM_178920 Q8BI08 uc007vrm.1 uc007vrm.2 uc007vrm.3 uc007vrm.4 Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway (By similarity). Interacts with TPD52L2. Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface (By similarity). Belongs to the MAL family. plasma membrane membrane integral component of membrane apical plasma membrane structural constituent of myelin sheath integral component of synaptic vesicle membrane myelination transcytosis membrane raft glutamatergic synapse uc007vrm.1 uc007vrm.2 uc007vrm.3 uc007vrm.4 
ENSMUST00000025357.9 Ap3s1 ENSMUST00000025357.9 adaptor-related protein complex 3, sigma 1 subunit, transcript variant 1 (from RefSeq NM_009681.5) AP3S1_MOUSE ENSMUST00000025357.1 ENSMUST00000025357.2 ENSMUST00000025357.3 ENSMUST00000025357.4 ENSMUST00000025357.5 ENSMUST00000025357.6 ENSMUST00000025357.7 ENSMUST00000025357.8 NM_009681 O88670 Q9DCR2 uc008evv.1 uc008evv.2 uc008evv.3 This gene encodes the sigma subunit of the heterotetrameric adaptor protein complex AP-3 which is involved in the formation of specialized lysosome-related compartments such as melanosomes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on chromosomes 1, 8, 16, 17 and X. [provided by RefSeq, Dec 2014]. Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). AP- 3 associates with the BLOC-1 complex. Interacts with AGAP1. Golgi apparatus. Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Belongs to the adaptor complexes small subunit family. Golgi apparatus trans-Golgi network intracellular protein transport anterograde axonal transport protein transport membrane vesicle-mediated transport membrane coat AP-3 adaptor complex cytoplasmic vesicle membrane cytoplasmic vesicle intracellular membrane-bounded organelle anterograde synaptic vesicle transport axon cytoplasm uc008evv.1 uc008evv.2 uc008evv.3 
ENSMUST00000025358.4 Lvrn ENSMUST00000025358.4 laeverin (from RefSeq NM_029008.1) E9QJR0 E9QJR0_MOUSE ENSMUST00000025358.1 ENSMUST00000025358.2 ENSMUST00000025358.3 Lvrn NM_029008 uc012bcu.1 uc012bcu.2 uc012bcu.3 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Note=Binds 1 zinc ion per subunit. Belongs to the peptidase M1 family. aminopeptidase activity proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding uc012bcu.1 uc012bcu.2 uc012bcu.3 
ENSMUST00000025363.7 Hbegf ENSMUST00000025363.7 heparin-binding EGF-like growth factor (from RefSeq NM_010415.2) ENSMUST00000025363.1 ENSMUST00000025363.2 ENSMUST00000025363.3 ENSMUST00000025363.4 ENSMUST00000025363.5 ENSMUST00000025363.6 Hbegf NM_010415 Q5FW64 Q5FW64_MOUSE uc008enl.1 uc008enl.2 uc008enl.3 uc008enl.4 uc008enl.5 Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. epidermal growth factor receptor binding extracellular space epidermal growth factor receptor signaling pathway growth factor activity heparin binding cell surface membrane integral component of membrane positive regulation of cell growth positive regulation of cell migration negative regulation of elastin biosynthetic process positive regulation of protein kinase B signaling cell chemotaxis positive regulation of wound healing uc008enl.1 uc008enl.2 uc008enl.3 uc008enl.4 uc008enl.5 
ENSMUST00000025364.6 Yipf5 ENSMUST00000025364.6 Yip1 domain family, member 5 (from RefSeq NM_023311.3) ENSMUST00000025364.1 ENSMUST00000025364.2 ENSMUST00000025364.3 ENSMUST00000025364.4 ENSMUST00000025364.5 NM_023311 Q9EQQ2 YIPF5_MOUSE Yip1a Yipf5 uc008etd.1 uc008etd.2 uc008etd.3 Plays a role in transport between endoplasmic reticulum and Golgi. In pancreatic beta cells, required to transport proinsulin from endoplasmic reticulum into the Golgi. Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B) (By similarity). Interacts with YIF1A (By similarity). May interact with RAB1A (By similarity). Interacts with YIPF3 and YIPF4 (By similarity). Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein Cytoplasmic vesicle, COPII-coated vesicle Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Enriched at the endoplasmic reticulum exit sites (PubMed:15254263). Incorporated into COPII coated vesicles (By similarity). Ubiquitously expressed. Belongs to the YIP1 family. molecular_function nucleoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus protein transport membrane integral component of membrane vesicle-mediated transport ER to Golgi transport vesicle cytoplasmic vesicle nuclear outer membrane-endoplasmic reticulum membrane network intracellular membrane-bounded organelle regulation of ER to Golgi vesicle-mediated transport endoplasmic reticulum exit site uc008etd.1 uc008etd.2 uc008etd.3 
ENSMUST00000025374.4 Pou4f3 ENSMUST00000025374.4 POU domain, class 4, transcription factor 3 (from RefSeq NM_138945.2) A6H6N6 Brn-3.1 Brn-3c Brn3c ENSMUST00000025374.1 ENSMUST00000025374.2 ENSMUST00000025374.3 NM_138945 PO4F3_MOUSE Pou4f3 Q63955 uc008etv.1 uc008etv.2 uc008etv.3 uc008etv.4 Acts as a transcriptional activator (PubMed:8290353, PubMed:7935408). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:7935408). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (PubMed:8637595). Interacts with ISL1 (PubMed:24643061). Nucleus Cytoplasm Note=Preferentially localized in the nucleus. Brain. Expressed in developing spinal cord from 13 dpc to postanal day 1, not expressed in adults (PubMed:8290353). Expressed by few neurons of dorsal root ganglion from, at least, 10.5 dpc to 15.5 dpc (PubMed:22326227). Mutants are deaf and show deficits in balance and coordination that become severe at about P14 and exhibit hyperactivity by 5-6 weeks. Belongs to the POU transcription factor family. Class-4 subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter sensory perception of sound vestibulocochlear nerve development cell differentiation retinal ganglion cell axon guidance inner ear morphogenesis auditory receptor cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter axon extension inner ear development neuromuscular process controlling balance neuron apoptotic process inner ear receptor cell differentiation uc008etv.1 uc008etv.2 uc008etv.3 uc008etv.4 
ENSMUST00000025375.15 Tcerg1 ENSMUST00000025375.15 transcription elongation regulator 1 (CA150), transcript variant 3 (from RefSeq NM_001360881.1) ENSMUST00000025375.1 ENSMUST00000025375.10 ENSMUST00000025375.11 ENSMUST00000025375.12 ENSMUST00000025375.13 ENSMUST00000025375.14 ENSMUST00000025375.2 ENSMUST00000025375.3 ENSMUST00000025375.4 ENSMUST00000025375.5 ENSMUST00000025375.6 ENSMUST00000025375.7 ENSMUST00000025375.8 ENSMUST00000025375.9 NM_001360881 Q61051 Q8C490 Q8CGF7 Q8CHT8 Q9R0R5 TCRG1_MOUSE Taf2s uc008etx.1 uc008etx.2 uc008etx.3 uc008etx.4 Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner (By similarity). Binds RNA polymerase II, HD and SF1 (By similarity). Binds formin. Interacts (via the second WW domain) with TREX1 (via proline- rich region). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CA150a; IsoId=Q8CGF7-1; Sequence=Displayed; Name=2; IsoId=Q8CGF7-2; Sequence=VSP_011655; Name=3; Synonyms=CA150b; IsoId=Q8CGF7-3; Sequence=VSP_011656, VSP_011657; The FF domains preferentially binds peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5) and mediate interaction with HTATSF1 and probably bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II. The WW domains bind Pro-rich domains. Sequence=AAH39185.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity nucleus nucleoplasm transcription, DNA-templated identical protein binding proline-rich region binding uc008etx.1 uc008etx.2 uc008etx.3 uc008etx.4 
ENSMUST00000025377.14 Ppp2r2b ENSMUST00000025377.14 protein phosphatase 2, regulatory subunit B, beta, transcript variant 4 (from RefSeq NR_175792.1) 2ABB_MOUSE ENSMUST00000025377.1 ENSMUST00000025377.10 ENSMUST00000025377.11 ENSMUST00000025377.12 ENSMUST00000025377.13 ENSMUST00000025377.2 ENSMUST00000025377.3 ENSMUST00000025377.4 ENSMUST00000025377.5 ENSMUST00000025377.6 ENSMUST00000025377.7 ENSMUST00000025377.8 ENSMUST00000025377.9 NR_175792 Q3UF60 Q6ZWR4 Q8K413 Q9D3B7 Q9D6I1 uc008euc.1 uc008euc.2 uc008euc.3 uc008euc.4 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TOMM22 (By similarity). Interacts with IER5 (via N- and C-terminal regions) (By similarity). [Isoform 1]: Cytoplasm. Cytoplasm, cytoskeleton. Membrane. [Isoform 2]: Cytoplasm Mitochondrion Mitochondrion outer membrane Note=Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Bbeta; IsoId=Q6ZWR4-1; Sequence=Displayed; Name=2; Synonyms=Bbeta2; IsoId=Q6ZWR4-2; Sequence=VSP_037983; Name=3; Synonyms=Bbeta1; IsoId=Q6ZWR4-3; Sequence=VSP_037982; Expressed in brain, testis, lung and spleen. In the brain, expressed in the cortex, hippocampus and cerebellum (at protein level). Expressed in embryo at 14 and 17 dpc. The N-terminal 26 residues of isoform 2 constitute a cryptic mitochondrial matrix import signal with critical basic and hydrophobic residues, that is necessary and sufficient for targeting the PP2A holoenzyme to the outer mitochondrial membrane (OMM) and does not affect holoenzyme formation or catalytic activity. The last WD repeat of isoform 2 constitutes a mitochondrial stop-transfer domain that confers resistance to the unfolding step process required for import and therefore prevents PPP2R2B matrix translocation and signal sequence cleavage. [Isoform 2]: Contains a cryptic mitochondrial transit peptide at positions 1-26. Belongs to the phosphatase 2A regulatory subunit B family. Sequence=BAB31079.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; Sequence=EDL10024.1; Type=Erroneous gene model prediction; Evidence=; protein phosphatase type 2A complex mitochondrial fission mitotic cell cycle cytoplasm mitochondrion mitochondrial outer membrane cytosol cytoskeleton protein targeting to mitochondrion apoptotic process membrane protein phosphatase regulator activity positive regulation of neuron apoptotic process mitochondrial fragmentation involved in apoptotic process regulation of phosphoprotein phosphatase activity macromolecular complex binding peptidyl-serine dephosphorylation protein serine/threonine phosphatase activity uc008euc.1 uc008euc.2 uc008euc.3 uc008euc.4 
ENSMUST00000025379.14 Dpysl3 ENSMUST00000025379.14 dihydropyrimidinase-like 3, transcript variant 2 (from RefSeq NM_009468.6) DPYL3_MOUSE Drp3 ENSMUST00000025379.1 ENSMUST00000025379.10 ENSMUST00000025379.11 ENSMUST00000025379.12 ENSMUST00000025379.13 ENSMUST00000025379.2 ENSMUST00000025379.3 ENSMUST00000025379.4 ENSMUST00000025379.5 ENSMUST00000025379.6 ENSMUST00000025379.7 ENSMUST00000025379.8 ENSMUST00000025379.9 NM_009468 Q62188 Ulip uc008euh.1 uc008euh.2 uc008euh.3 uc008euh.4 uc008euh.5 This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin (By similarity). Interacts with FLNA (By similarity). Cytoplasm Cell projection, growth cone Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure. protein binding extracellular space cytoplasm cytosol nervous system development regulation of neuron projection development positive regulation of neuron projection development negative regulation of neuron projection development hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides SH3 domain binding lamellipodium regulation of cell migration negative regulation of cell migration growth cone filamin binding filamentous actin chondroitin sulfate binding cell projection cell body synapse response to axon injury actin filament bundle assembly phosphoprotein binding protein homooligomerization positive regulation of filopodium assembly actin crosslink formation cellular response to cytokine stimulus exocytic vesicle dihydropyrimidinase activity pyrimidine nucleobase catabolic process uc008euh.1 uc008euh.2 uc008euh.3 uc008euh.4 uc008euh.5 
ENSMUST00000025381.4 Spink1 ENSMUST00000025381.4 serine peptidase inhibitor, Kazal type 1 (from RefSeq NM_009258.5) ENSMUST00000025381.1 ENSMUST00000025381.2 ENSMUST00000025381.3 ISK1_MOUSE NM_009258 P09036 Q5M9M3 Spink1 Spink3 uc008eul.1 uc008eul.2 uc008eul.3 uc008eul.4 Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:3428272, PubMed:14645103, PubMed:22228629). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (PubMed:16083722). In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production (PubMed:9828198, PubMed:14645103, PubMed:16083722, PubMed:22228629). Secreted In the genital tract, expressed only in male accessory glands including seminal vesicle, coagulating gland and prostate. In the seminal vesicle, not expressed during prepubertal stages; expression coincides with maturation. By androgens in adult male sex accessory glands. Expressed constitutively in pancreas. Lethal with no survival past two weeks of age. Animals are small and show severe, progressive degeneration of pancreatic tissue associated with autophagic cell death. serine-type endopeptidase inhibitor activity extracellular region extracellular space negative regulation of peptidase activity negative regulation of nitric oxide mediated signal transduction peptidase inhibitor activity sperm capacitation negative regulation of peptidyl-tyrosine phosphorylation regulation of acrosome reaction negative regulation of calcium ion import negative regulation of serine-type endopeptidase activity regulation of store-operated calcium entry uc008eul.1 uc008eul.2 uc008eul.3 uc008eul.4 
ENSMUST00000025385.7 Hsd17b4 ENSMUST00000025385.7 hydroxysteroid (17-beta) dehydrogenase 4 (from RefSeq NM_008292.4) DHB4_MOUSE ENSMUST00000025385.1 ENSMUST00000025385.2 ENSMUST00000025385.3 ENSMUST00000025385.4 ENSMUST00000025385.5 ENSMUST00000025385.6 Edh17b4 Hsd17b4 NM_008292 P51660 Q9DBM3 uc008eww.1 uc008eww.2 uc008eww.3 uc008eww.4 Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway (PubMed:17442273). Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2- enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched- chain fatty acids, as well as bile acid intermediates as substrates (By similarity) (PubMed:17442273). Reaction=a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:32711, ChEBI:CHEBI:15378, ChEBI:CHEBI:57319, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.n12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32712; Evidence=; Reaction=(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta- cholestan-26-oyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta- cholest-24-en-26-oyl-CoA + H2O; Xref=Rhea:RHEA:18933, ChEBI:CHEBI:15377, ChEBI:CHEBI:59807, ChEBI:CHEBI:59879; EC=4.2.1.107; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18935; Evidence=; Reaction=a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O; Xref=Rhea:RHEA:26526, ChEBI:CHEBI:15377, ChEBI:CHEBI:57319, ChEBI:CHEBI:58856; EC=4.2.1.119; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:26528; Evidence=; Reaction=(2E)-octenoyl-CoA + H2O = (3R)-hydroxyoctanoyl-CoA; Xref=Rhea:RHEA:40187, ChEBI:CHEBI:15377, ChEBI:CHEBI:62242, ChEBI:CHEBI:74279; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40188; Evidence=; Reaction=(3R)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:40191, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62619, ChEBI:CHEBI:74279; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40192; Evidence=; Reaction=(3R)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:40243, ChEBI:CHEBI:15378, ChEBI:CHEBI:57349, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:74278; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40244; Evidence=; Reaction=(2E)-hexadecenedioyl-CoA + H2O = (3R)-hydroxyhexadecanedioyl- CoA; Xref=Rhea:RHEA:40255, ChEBI:CHEBI:15377, ChEBI:CHEBI:77075, ChEBI:CHEBI:77079; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40256; Evidence=; Reaction=(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3- oxohexadecanedioyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:40263, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:77079, ChEBI:CHEBI:77081; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40264; Evidence=; Reaction=(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O; Xref=Rhea:RHEA:39159, ChEBI:CHEBI:15377, ChEBI:CHEBI:61526, ChEBI:CHEBI:74278; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:39161; Evidence=; Reaction=(3R)-3-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O; Xref=Rhea:RHEA:45992, ChEBI:CHEBI:15377, ChEBI:CHEBI:61406, ChEBI:CHEBI:74272; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:45994; Evidence=; Reaction=(3R)-3-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:45832, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62548, ChEBI:CHEBI:74272; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45833; Evidence=; Reaction=(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta- cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha,12alpha-trihydroxy-24- oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:47088, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58507, ChEBI:CHEBI:59807; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47089; Evidence=; Lipid metabolism; fatty acid beta-oxidation. Homodimer. P51660; P42858: HTT; Xeno; NbExp=15; IntAct=EBI-8328056, EBI-466029; Peroxisome Present in many tissues with highest concentrations in liver and kidney. The protein is found both as a full-length peptide and in a cleaved version. Belongs to the short-chain dehydrogenases/reductases (SDR) family. very long-chain fatty acid metabolic process 3-hydroxyacyl-CoA dehydrogenase activity estradiol 17-beta-dehydrogenase activity mitochondrion peroxisome peroxisomal matrix lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation androgen metabolic process estrogen metabolic process oxidoreductase activity long-chain-enoyl-CoA hydratase activity lyase activity isomerase activity 3-hydroxyacyl-CoA dehydratase activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity very long-chain fatty-acyl-CoA metabolic process medium-chain fatty-acyl-CoA metabolic process protein homodimerization activity 17-beta-hydroxysteroid dehydrogenase (NAD+) activity oxidation-reduction process Sertoli cell development uc008eww.1 uc008eww.2 uc008eww.3 uc008eww.4 
ENSMUST00000025388.7 Ftmt ENSMUST00000025388.7 ferritin mitochondrial (from RefSeq NM_026286.3) ENSMUST00000025388.1 ENSMUST00000025388.2 ENSMUST00000025388.3 ENSMUST00000025388.4 ENSMUST00000025388.5 ENSMUST00000025388.6 FTMT_MOUSE Ftmt NM_026286 Q14BZ8 Q3V0N6 Q9D5F4 Q9D5H4 uc008exc.1 uc008exc.2 uc008exc.3 uc008exc.4 uc008exc.5 Catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Reaction=4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O; Xref=Rhea:RHEA:11148, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.16.3.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11149; Evidence=; Homooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited (By similarity). Mitochondrion Belongs to the ferritin family. Sequence=BAB29806.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; ferroxidase activity iron ion binding cytoplasm mitochondrion iron ion transport cellular iron ion homeostasis intracellular sequestering of iron ion ferrous iron binding ferric iron binding positive regulation of cell proliferation oxidoreductase activity identical protein binding metal ion binding positive regulation of lyase activity oxidation-reduction process positive regulation of succinate dehydrogenase activity positive regulation of aconitate hydratase activity uc008exc.1 uc008exc.2 uc008exc.3 uc008exc.4 uc008exc.5 
ENSMUST00000025390.4 Dynap ENSMUST00000025390.4 dynactin associated protein (from RefSeq NM_029346.1) Dynap ENSMUST00000025390.1 ENSMUST00000025390.2 ENSMUST00000025390.3 NM_029346 Q9D7M5 Q9D7M5_MOUSE uc008fob.1 uc008fob.2 uc008fob.3 uc008fob.4 molecular_function membrane integral component of membrane uc008fob.1 uc008fob.2 uc008fob.3 uc008fob.4 
ENSMUST00000025393.14 Smad4 ENSMUST00000025393.14 SMAD family member 4, transcript variant 4 (from RefSeq NR_157374.1) Dpc4 ENSMUST00000025393.1 ENSMUST00000025393.10 ENSMUST00000025393.11 ENSMUST00000025393.12 ENSMUST00000025393.13 ENSMUST00000025393.2 ENSMUST00000025393.3 ENSMUST00000025393.4 ENSMUST00000025393.5 ENSMUST00000025393.6 ENSMUST00000025393.7 ENSMUST00000025393.8 ENSMUST00000025393.9 Madh4 NR_157374 P97471 Q6GTP6 Q9CW56 SMAD4_MOUSE uc008fov.1 uc008fov.2 uc008fov.3 Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Monomer; in the absence of TGF-beta activation (By similarity). Heterotrimer; on TGF-beta activation (By similarity). Heterotrimer composed of two molecules of a C-terminally phosphorylated R-SMAD molecule, SMAD2 or SMAD3, and one molecule of SMAD4 to form the transcriptional active SMAD2/SMAD3-SMAD4 complex (PubMed:21145499). Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Interacts with ATF2, COPS5, DACH1, MSG1, SKI, STK11/LKB1, STK11IP and TRIM33. Found in a complex with SMAD1 and YY1 (PubMed:15329343). Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4 (By similarity). Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with USP9X. Interacts with RBPMS. Interacts with WWTR1 (via coiled-coil domain). Interacts with CITED1 and CITED2 (By similarity). Interacts with PDPK1 (via PH domain) (By similarity). Interacts with VPS39; this interaction affects heterodimer formation with SMAD3, but not with SMAD2, and leads to inhibition of SMAD3-dependent transcription activation (By similarity). Interactions with VPS39 and SMAD2 may be mutually exclusive (By similarity). Interacts (via MH2 domain) with ZNF451 (via N-terminal zinc-finger domains) (By similarity). Found in a complex with SMAD1 and YY1 (PubMed:15329343). Interacts with ZC3H3 (PubMed:16115198). Interacts weakly with ZNF8 (PubMed:12370310). Interacts with NUP93 and IPO7; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling (By similarity). Interacts with CREB3L1, the interaction takes place upon TGFB1 induction and SMAD4 acts as a CREB3L1 coactivator to induce the expression of genes involved in the assembly of collagen extracellular matrix (By similarity). Interacts with DLX1 (By similarity). Interacts with ZBTB7A; the interaction is direct and stimulated by TGFB1 (By similarity). Interacts with CREBBP; the recruitment of this transcriptional coactivator is negatively regulated by ZBTB7A (By similarity). Interacts with EP300; the interaction with this transcriptional coactivator is negatively regulated by ZBTB7A (By similarity). Interacts with HDAC1 (By similarity). Interacts (via MH2 domain) with ZMIZ1 (via SP-RING-type domain); in the TGF-beta signaling pathway increases the activity of the SMAD3/SMAD4 transcriptional complex (By similarity). Interacts (via N-terminus) with TSC22D1 (By similarity). P97471; Q8R1H0: Hopx; NbExp=2; IntAct=EBI-5259270, EBI-6913924; P97471; Q60698: Ski; NbExp=3; IntAct=EBI-5259270, EBI-15969860; P97471; Q8BUN5: Smad3; NbExp=6; IntAct=EBI-5259270, EBI-2337983; Cytoplasm Nucleus Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD. PDPK1 prevents its nuclear translocation. Ubiquitous. The MH1 domain is required for DNA binding. The MH2 domain is required for both homomeric and heteromeric interactions and for transcriptional regulation. Sufficient for nuclear import (By similarity). Phosphorylated by PDPK1. Monoubiquitinated on Lys-518 by E3 ubiquitin-protein ligase TRIM33. Monoubiquitination hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination by USP9X restores its competence to mediate TGF-beta signaling (By similarity). Conditional knockout in muscle leads to muscle atrophy and weakness. Mutant mice loose significantly more muscle mass after denervation as compared to wild-type animals and show excessive proteolysis in denervated muscle. The loss of maximal absolute force after fasting is greater in mutant mice than in controls. Belongs to the dwarfin/SMAD family. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ovarian follicle development osteoblast differentiation branching involved in ureteric bud morphogenesis response to hypoxia in utero embryonic development gastrulation with mouth forming second kidney development outflow tract septum morphogenesis atrioventricular valve formation epithelial to mesenchymal transition involved in endocardial cushion formation left ventricular cardiac muscle tissue morphogenesis positive regulation of cell proliferation involved in heart valve morphogenesis cardiac septum development brainstem development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription cofactor activity protein binding collagen binding nucleus nucleoplasm transcription factor complex cytoplasm centrosome cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cellular iron ion homeostasis transforming growth factor beta receptor signaling pathway SMAD protein complex assembly spermatogenesis single fertilization gastrulation axon guidance endoderm development mesoderm development cell proliferation negative regulation of cell proliferation male gonad development female gonad development anatomical structure morphogenesis anterior/posterior pattern specification negative regulation of cardiac muscle hypertrophy positive regulation of cardiac muscle cell apoptotic process positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation neural crest cell differentiation regulation of transforming growth factor beta receptor signaling pathway cell differentiation negative regulation of cell growth BMP signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of BMP signaling pathway transforming growth factor beta receptor, common-partner cytoplasmic mediator activity filamin binding activin responsive factor complex somite rostral/caudal axis specification regulation of transforming growth factor beta2 production macromolecular complex positive regulation of luteinizing hormone secretion intracellular signal transduction atrioventricular canal development wound healing endothelial cell activation regulation of cell proliferation negative regulation of protein catabolic process embryonic digit morphogenesis identical protein binding protein homodimerization activity sulfate binding sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter SMAD binding metal ion binding positive regulation of follicle-stimulating hormone secretion mesendoderm development developmental growth neuron fate commitment tissue morphogenesis sebaceous gland development formation of anatomical boundary regulation of binding positive regulation of histone H3-K4 methylation regulation of hair follicle development uterus development positive regulation of SMAD protein import into nucleus SMAD protein signal transduction ventricular septum morphogenesis negative regulation of cell death endocardial cell differentiation female gonad morphogenesis pri-miRNA transcription from RNA polymerase II promoter interleukin-6-mediated signaling pathway protein homotrimerization ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade I-SMAD binding R-SMAD binding SMAD protein complex cellular response to glucose stimulus response to transforming growth factor beta metanephric mesenchyme morphogenesis nephrogenic mesenchyme morphogenesis seminiferous tubule development RNA polymerase II transcription factor complex molecular function regulator negative regulation of cardiac myofibril assembly positive regulation of histone H3-K9 acetylation uc008fov.1 uc008fov.2 uc008fov.3 
ENSMUST00000025394.14 Sec11c ENSMUST00000025394.14 SEC11 homolog C, signal peptidase complex subunit (from RefSeq NM_025468.2) ENSMUST00000025394.1 ENSMUST00000025394.10 ENSMUST00000025394.11 ENSMUST00000025394.12 ENSMUST00000025394.13 ENSMUST00000025394.2 ENSMUST00000025394.3 ENSMUST00000025394.4 ENSMUST00000025394.5 ENSMUST00000025394.6 ENSMUST00000025394.7 ENSMUST00000025394.8 ENSMUST00000025394.9 NM_025468 Q9D8V7 SC11C_MOUSE Sec11l3 Spc21 uc008ffh.1 uc008ffh.2 uc008ffh.3 uc008ffh.4 Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids. Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.; EC=3.4.21.89; Evidence=; Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3. Within the complex, interacts with SPCS2 and SPCS3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. Endoplasmic reticulum membrane ; Single-pass type II membrane protein The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates. May undergo processing at the N-terminus. Belongs to the peptidase S26B family. endoplasmic reticulum signal peptidase complex endoplasmic reticulum membrane signal peptide processing proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity organelle membrane intracellular membrane-bounded organelle uc008ffh.1 uc008ffh.2 uc008ffh.3 uc008ffh.4 
ENSMUST00000025396.5 Rax ENSMUST00000025396.5 retina and anterior neural fold homeobox (from RefSeq NM_013833.2) ENSMUST00000025396.1 ENSMUST00000025396.2 ENSMUST00000025396.3 ENSMUST00000025396.4 NM_013833 O08748 O35602 Q6GT92 RX_MOUSE Rx uc008ffl.1 uc008ffl.2 uc008ffl.3 Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE- 1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity). Nucleus. Expressed in the photoreceptor and inner nuclear layers. Strongly expressed in anterior neural plate at 8.5 dpc, followed in optic sulci and ventral forebrain at 9.0 dpc, and in eye at 10.5 dpc uniformly expressed in neuroretina at 15.5 dpc, and at later stages, expression decreases. Belongs to the paired homeobox family. Bicoid subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development pattern specification process brain development hypothalamus development camera-type eye development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter limb development uc008ffl.1 uc008ffl.2 uc008ffl.3 
ENSMUST00000025397.7 Cplx4 ENSMUST00000025397.7 complexin 4 (from RefSeq NM_145493.1) CPLX4_MOUSE ENSMUST00000025397.1 ENSMUST00000025397.2 ENSMUST00000025397.3 ENSMUST00000025397.4 ENSMUST00000025397.5 ENSMUST00000025397.6 NM_145493 Q80WM3 Q8C8Y0 Q91WE5 uc008ffm.1 uc008ffm.2 uc008ffm.3 uc008ffm.4 Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (PubMed:19386896). Required for the maintenance of synaptic ultrastructure in the adult retina (PubMed:19386896). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (PubMed:15911881, PubMed:19386896, PubMed:27335398). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (PubMed:22694764, PubMed:27335398). Weakly binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A. Synapse ll membrane ; Lipid-anchor Note=Enriched at the synaptic terminal. Present specifically in the retina (at protein level) (PubMed:15911881, PubMed:19386896, PubMed:22694764, PubMed:27335398). Expressed in the outer nuclear layer of the retina (at protein level) (PubMed:22694764). Strongly expressed at rod photoreceptor ribbon synapses (at protein level) (PubMed:15911881, PubMed:22694764). Not expressed at conventional amacrine cell synapses, nor at cone photoreceptor ribbon synapses (at protein level) (PubMed:15911881). Weakly expressed at cone photoreceptor synaptic terminals (at protein level) (PubMed:22694764). Not expressed in the brain (at protein level) (PubMed:19386896). Farnesylation mediates presynaptic targeting and is important for function in neurotransmitter release. Knockout mice are generally phenotypically normal, viable, and fertile (PubMed:19386896). Normal overall retina structure and morphology of the outer plexiform layer (OPL) and inner plexiform layer (IPL) (PubMed:19386896). Abundance and distribution of synaptic proteins remain consistent (PubMed:19386896). Reduced inner retinal processing and retinal synaptic transmission at low light intensities (PubMed:19386896). Cplx3 and Cplx4 double knockout mice are generally phenotypically normal, viable, and fertile, however show disordered morphology of the OPL and vision perturbation when compared to single knockout mice (PubMed:19386896). Cplx3 and Cplx4 double knockout mice show evidence of mild vision perturbation, with a reduction in the number of morphologically normal anchored presynaptic ribbon synapses and a decrease in controlled neurotransmitter release at photoreceptor ribbon synapses (PubMed:19386896). Cplx3 and Cplx4 double knockout mice show a reduced response and sensitivity of ON and OFF ganglion cell response as a result of disrupted synaptic transmission (PubMed:22694764). Cplx3 and Cplx4 double knockout mice show a greater variance in photoreceptor activity response and a decrease in sustained response, this is caused by an increase in release and fusion of synaptic vesicles in an asynchronous manner, this is particularly evident following multiple stimuli (PubMed:27335398). Belongs to the complexin/synaphin family. SNARE binding plasma membrane neurotransmitter transport exocytosis visual perception membrane synaptic vesicle exocytosis syntaxin binding cell junction SNARE complex terminal bouton synapse regulation of neurotransmitter secretion response to stimulus uc008ffm.1 uc008ffm.2 uc008ffm.3 uc008ffm.4 
ENSMUST00000025399.9 Pmaip1 ENSMUST00000025399.9 phorbol-12-myristate-13-acetate-induced protein 1 (from RefSeq NM_021451.2) APR_MOUSE ENSMUST00000025399.1 ENSMUST00000025399.2 ENSMUST00000025399.3 ENSMUST00000025399.4 ENSMUST00000025399.5 ENSMUST00000025399.6 ENSMUST00000025399.7 ENSMUST00000025399.8 NM_021451 Noxa Q9JM54 uc008fft.1 uc008fft.2 uc008fft.3 uc008fft.4 Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Interacts with MCL1 (PubMed:10807576, PubMed:15901672, PubMed:15694340, PubMed:17389404). Interacts with BCL2A1 (By similarity). Interacts with BAX (By similarity). Interacts with BCL2L10 (By similarity). Q9JM54; P97287: Mcl1; NbExp=14; IntAct=EBI-709183, EBI-707292; Q9JM54; Q07820: MCL1; Xeno; NbExp=2; IntAct=EBI-709183, EBI-1003422; Mitochondrion Detected in thymocytes after irradiation with X- rays. Not detectable in untreated thymocytes (at protein level). Detected in embryonic neural precursor cells of the telencephalon Constitutively expressed at low levels in adult brain, testis, thymus, spleen, lung and kidney. Up-regulated after exposure to ionizing radiation and other genotoxic agents. Up-regulation is mediated by p53. The BH3 motif is essential for pro-apoptotic activity. Belongs to the PMAIP1 family. release of cytochrome c from mitochondria protein binding mitochondrion apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus intrinsic apoptotic signaling pathway in response to DNA damage response to UV response to X-ray negative regulation of mitochondrial membrane potential intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process T cell homeostasis positive regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of neuron apoptotic process negative regulation of fibroblast proliferation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway uc008fft.1 uc008fft.2 uc008fft.3 uc008fft.4 
ENSMUST00000025403.8 Impa2 ENSMUST00000025403.8 inositol monophosphatase 2 (from RefSeq NM_053261.3) ENSMUST00000025403.1 ENSMUST00000025403.2 ENSMUST00000025403.3 ENSMUST00000025403.4 ENSMUST00000025403.5 ENSMUST00000025403.6 ENSMUST00000025403.7 IMPA2_MOUSE NM_053261 Q91UZ5 uc008fly.1 uc008fly.2 uc008fly.3 uc008fly.4 Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain (By similarity). Reaction=a myo-inositol phosphate + H2O = myo-inositol + phosphate; Xref=Rhea:RHEA:24056, ChEBI:CHEBI:15377, ChEBI:CHEBI:17268, ChEBI:CHEBI:43474, ChEBI:CHEBI:84139; EC=3.1.3.25; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2. Homodimer. Cytoplasm Mostly expressed in brain, small intestine, heart, kidney, and spleen (at protein level). Belongs to the inositol monophosphatase superfamily. cytoplasm inositol metabolic process inositol biosynthetic process signal transduction inositol monophosphate 1-phosphatase activity hydrolase activity protein homodimerization activity phosphatidylinositol phosphorylation inositol phosphate dephosphorylation metal ion binding inositol monophosphate 3-phosphatase activity inositol monophosphate 4-phosphatase activity inositol monophosphate phosphatase activity uc008fly.1 uc008fly.2 uc008fly.3 uc008fly.4 
ENSMUST00000025404.10 Cidea ENSMUST00000025404.10 cell death-inducing DNA fragmentation factor, alpha subunit-like effector A (from RefSeq NM_007702.2) CIDEA_MOUSE Cidea ENSMUST00000025404.1 ENSMUST00000025404.2 ENSMUST00000025404.3 ENSMUST00000025404.4 ENSMUST00000025404.5 ENSMUST00000025404.6 ENSMUST00000025404.7 ENSMUST00000025404.8 ENSMUST00000025404.9 NM_007702 O70302 Q4V9X2 uc012beh.1 uc012beh.2 uc012beh.3 Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:18509062, PubMed:22144693, PubMed:26609809, PubMed:36477540). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:18509062, PubMed:22144693, PubMed:26609809). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (PubMed:18509062, PubMed:22144693, PubMed:26609809). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC (PubMed:18509062, PubMed:22144693). May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein (PubMed:22245780). By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (PubMed:22245780). When overexpressed, induces apoptosis; the physiological significance of its role in apoptosis is unclear (PubMed:9564035). Reaction=a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out); Xref=Rhea:RHEA:39011, ChEBI:CHEBI:64615; Evidence=; Homodimer (PubMed:26609809). Interacts with CIDEC (By similarity). Directly interacts with CEBPB (PubMed:22245780). Interacts with isoform CLSTN3beta of CLSTN3; inhibiting the lipid transferase activity of CIDEA (PubMed:36477540). O70302; Q9Y478: PRKAB1; Xeno; NbExp=4; IntAct=EBI-7927848, EBI-719769; Lipid droplet cleus Note=Enriched at lipid droplet contact sites (PubMed:18509062, PubMed:22144693). Using a GFP-tagged construct, has been shown to localize to mitochondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (PubMed:12910269). These data could not be confirmed (PubMed:18509062, PubMed:22245780). Highly expressed in brown adipose tissue and, at lower levels, in white adipose tissue (at protein level) (PubMed:12910269, PubMed:18509062). Undetectable in undifferentiated preadipocytes (PubMed:12910269, PubMed:18509062). Expressed in mammary gland during pregnancy and lactation, in epithelial cells, but not in the surrounding adipose tissue (PubMed:22245780). Secreted into milk via milk fat globules (PubMed:22245780). Expressed at 15 dpc in the interscapular region of the embryo, that could correspond to the developing brown adipose tissue. Expression continues in the interscapular region at 18 dpc and postnatally. In mammary glands, begins to be highly expressed at day 14.5 of pregnancy. Expression is maintained at high levels throughout lactation and declines during post-lactational involution. Up-regulated under conditions that enhance triacylglycerol deposition, including rosiglitazone treatment and high-fat diet. This up-regulation is mediated by PPARG. The amphipathic helix mediates embedding into the lipid droplet phospholipid monolayer, promoting phosphatidic acid-binding, thereby facilitating triacylglycerol transfer. The CIDE-N domain is involved in homodimerization which is crucial for its function in promoting lipid exchange and transfer. Mutant animals appear normal and fertile and produce the expected Mendelian ratio of heterozygous and homozygous descendents. They are lean and resistant to diet-induced obesity and diabetes. They exhibit higher metabolic rate, lipolysis in brown adipose tissue and core body temperature when subjected to cold treatment. Mutant females are unable to properly feed their pups who die within 3 days postpartum due to severely reduced milk lipids. Belongs to the CIDE family. temperature homeostasis protein binding nucleus cytoplasm mitochondrion mitochondrial envelope lipid particle lipid metabolic process apoptotic process cell death positive regulation of sequestering of triglyceride lipid storage negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of tumor necrosis factor production response to stilbenoid protein homodimerization activity negative regulation of cytokine secretion negative regulation of lipid catabolic process negative regulation of execution phase of apoptosis regulation of apoptotic DNA fragmentation uc012beh.1 uc012beh.2 uc012beh.3 
ENSMUST00000025406.9 Srfbp1 ENSMUST00000025406.9 serum response factor binding protein 1 (from RefSeq NM_026040.4) ENSMUST00000025406.1 ENSMUST00000025406.2 ENSMUST00000025406.3 ENSMUST00000025406.4 ENSMUST00000025406.5 ENSMUST00000025406.6 ENSMUST00000025406.7 ENSMUST00000025406.8 NM_026040 Q3UGY0 Q3UMK2 Q3UR20 Q8R3W6 Q9CRL0 Q9CZ91 SRFB1_MOUSE Srfbp1 uc008exd.1 uc008exd.2 uc008exd.3 May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4. Cytoplasm, perinuclear region Highly expressed in heart, skeletal muscle, liver, kidney, testis and brain. Also expressed in white adipose tissue. Expression is up-regulated in cardiomyopathic heart. Up-regulated in adult heart (at protein level). protein binding nucleus cytoplasm maturation of SSU-rRNA 90S preribosome perinuclear region of cytoplasm uc008exd.1 uc008exd.2 uc008exd.3 
ENSMUST00000025408.10 Afg3l2 ENSMUST00000025408.10 AFG3-like AAA ATPase 2 (from RefSeq NM_027130.2) AFG32_MOUSE Afg3l2 ENSMUST00000025408.1 ENSMUST00000025408.2 ENSMUST00000025408.3 ENSMUST00000025408.4 ENSMUST00000025408.5 ENSMUST00000025408.6 ENSMUST00000025408.7 ENSMUST00000025408.8 ENSMUST00000025408.9 NM_027130 Q8JZQ2 uc008fmf.1 uc008fmf.2 uc008fmf.3 uc008fmf.4 ATP-dependent protease which is essential for axonal and neuron development (PubMed:18337413, PubMed:27642048). In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (By similarity). Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (By similarity). Involved in the regulation of OMA1-dependent processing of OPA1 (By similarity). Contributes to the proteolytic degradation of GHITM upon hyperpolarization of mitochondria (By similarity). Progressive GHITM degradation upon persistent hyperpolarization leads to respiratory complex I degradation and broad reshaping of the mitochondrial proteome by AFG3L2 (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Homooligomer (PubMed:17101804). Forms heterooligomers with SPG7 and AFG3L1 (PubMed:17101804, PubMed:19656850). Interacts with SPG7; the interaction is required for the efficient assembly of mitochondrial complex I (PubMed:22563492, PubMed:19656850). Interacts with AFG3L1 (PubMed:19656850). Interacts with MAIP1 (PubMed:27642048). Interacts with DNAJC19 and PHB2 (PubMed:24856930). Interacts with GHITM (By similarity). Mitochondrion inner membrane ; Multi-pass membrane protein Highly expressed in the cerebellar Purkinje cells. Upon import into the mitochondrion, the N-terminal transit peptide is cleaved to generate an intermediate form which undergoes autocatalytic proteolytic processing to generate the proteolytically active mature form. Note=Defects in Afg3l2 are the cause of the paralyze (par) phenotype, a spontaneous mutant strain. Par mice have a normal appearance and fertility but are significantly smaller than their littermates at 1 week of age and display a rapidly progressive loss of motor function in all limbs by 12-14 days. As the disease progresses, they lose the ability to support their own weight or turn themselves over when placed on their back and exhibit a typical posture with over extension of all limbs and uncoordinated movements. They rarely survive beyond 16 days of age, when they are completely paralyzed. In the N-terminal section; belongs to the AAA ATPase family. In the C-terminal section; belongs to the peptidase M41 family. nucleotide binding metalloendopeptidase activity protein binding ATP binding mitochondrion mitochondrial inner membrane m-AAA complex proteolysis mitochondrion organization axonogenesis neuromuscular junction development mitochondrial fusion peptidase activity metallopeptidase activity zinc ion binding membrane integral component of membrane protein processing protein autoprocessing hydrolase activity nerve development mitochondrial protein processing mitochondrial calcium uptake regulation of multicellular organism growth cristae formation myelination metal ion binding muscle fiber development mitochondrial calcium ion homeostasis righting reflex uc008fmf.1 uc008fmf.2 uc008fmf.3 uc008fmf.4 
ENSMUST00000025411.9 Prelid3a ENSMUST00000025411.9 PRELI domain containing 3A (from RefSeq NM_144867.2) ENSMUST00000025411.1 ENSMUST00000025411.2 ENSMUST00000025411.3 ENSMUST00000025411.4 ENSMUST00000025411.5 ENSMUST00000025411.6 ENSMUST00000025411.7 ENSMUST00000025411.8 NM_144867 PLD3A_MOUSE Q8VE85 Slmo1 uc008fmk.1 uc008fmk.2 uc008fmk.3 In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane. Interacts with TRIAP1. Mitochondrion Belongs to the slowmo family. mitochondrion mitochondrial intermembrane space lipid transport phospholipid transport phosphatidic acid transporter activity uc008fmk.1 uc008fmk.2 uc008fmk.3 
ENSMUST00000025418.4 Psmg2 ENSMUST00000025418.4 proteasome (prosome, macropain) assembly chaperone 2, transcript variant 1 (from RefSeq NM_134138.2) Clast3 ENSMUST00000025418.1 ENSMUST00000025418.2 ENSMUST00000025418.3 NM_134138 PSMG2_MOUSE Psmg2 Q3TII5 Q3UXH7 Q8C1R5 Q91YJ0 Q9EST4 Tnfsf5ip1 uc008fmt.1 uc008fmt.2 Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity). Forms a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q9EST4-1; Sequence=Displayed; Name=2 ; IsoId=Q9EST4-2; Sequence=VSP_052692, VSP_052693; Name=3 ; IsoId=Q9EST4-3; Sequence=VSP_052691; Expression is elevated in proliferating cells and down-regulated in cells undergoing growth arrest. During the cell cycle, expression is low in G1-arrested cells, increases during S phase and remains high at G2-M phase. Degraded by the proteasome upon completion of 20S proteasome maturation. Belongs to the PSMG2 family. molecular_function nucleus cytosol mitotic spindle assembly checkpoint negative regulation of apoptotic process proteasome assembly regulation of cell cycle uc008fmt.1 uc008fmt.2 
ENSMUST00000025419.9 Ppic ENSMUST00000025419.9 peptidylprolyl isomerase C (from RefSeq NM_008908.4) ENSMUST00000025419.1 ENSMUST00000025419.2 ENSMUST00000025419.3 ENSMUST00000025419.4 ENSMUST00000025419.5 ENSMUST00000025419.6 ENSMUST00000025419.7 ENSMUST00000025419.8 NM_008908 Ppic Q3UC73 Q3UC73_MOUSE uc008exu.1 uc008exu.2 uc008exu.3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Belongs to the cyclophilin-type PPIase family. protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity protein folding cyclosporin A binding isomerase activity uc008exu.1 uc008exu.2 uc008exu.3 
ENSMUST00000025421.9 Seh1l ENSMUST00000025421.9 SEH1-like (S. cerevisiae, transcript variant 1 (from RefSeq NM_001039088.1) ENSMUST00000025421.1 ENSMUST00000025421.2 ENSMUST00000025421.3 ENSMUST00000025421.4 ENSMUST00000025421.5 ENSMUST00000025421.6 ENSMUST00000025421.7 ENSMUST00000025421.8 NM_001039088 Q3TLC9 Q3UP79 Q8R2U0 Q9D0K7 SEH1_MOUSE uc008fmy.1 uc008fmy.2 uc008fmy.3 uc008fmy.4 Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex. The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids. In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated. Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13. The SEH1 subunit appears to be only weakly associated with the Nup107-160 subcomplex. Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids. SESN1, SESN2 and SESN3 convey leucine availability via direct interaction with SEH1L and WDR24. Chromosome, centromere, kinetochore Nucleus, nuclear pore complex Lysosome membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R2U0-1; Sequence=Displayed; Name=2; IsoId=Q8R2U0-2; Sequence=VSP_037232; Belongs to the WD repeat SEC13 family. Sequence=BAE25518.1; Type=Frameshift; Evidence=; chromosome, centromeric region kinetochore condensed chromosome kinetochore cytokine production involved in inflammatory response structural molecule activity nucleus nuclear pore chromosome lysosome lysosomal membrane nuclear pore organization cell cycle chromosome segregation mitotic metaphase plate congression protein transport membrane nuclear pore outer ring positive regulation of TOR signaling cellular response to amino acid starvation cellular protein complex localization Seh1-associated complex defense response to Gram-positive bacterium mRNA transport cell division attachment of mitotic spindle microtubules to kinetochore GATOR2 complex positive regulation of TORC1 signaling uc008fmy.1 uc008fmy.2 uc008fmy.3 uc008fmy.4 
ENSMUST00000025425.7 Cep192 ENSMUST00000025425.7 centrosomal protein 192 (from RefSeq NM_027556.1) Cep192 E9Q4Y4 E9Q4Y4_MOUSE ENSMUST00000025425.1 ENSMUST00000025425.2 ENSMUST00000025425.3 ENSMUST00000025425.4 ENSMUST00000025425.5 ENSMUST00000025425.6 NM_027556 uc012bel.1 uc012bel.2 pericentriolar material cytoplasm centrosome centriole cytosol microtubule nucleation mitotic spindle assembly checkpoint response to bacterium negative regulation of phosphatase activity phosphatase binding regulation of centriole replication regulation of centrosome cycle centrosome duplication regulation of establishment of protein localization protein localization to centrosome centrosome-templated microtubule nucleation mitotic spindle assembly uc012bel.1 uc012bel.2 
ENSMUST00000025430.11 Setbp1 ENSMUST00000025430.11 SET binding protein 1 (from RefSeq NM_053099.3) ENSMUST00000025430.1 ENSMUST00000025430.10 ENSMUST00000025430.2 ENSMUST00000025430.3 ENSMUST00000025430.4 ENSMUST00000025430.5 ENSMUST00000025430.6 ENSMUST00000025430.7 ENSMUST00000025430.8 ENSMUST00000025430.9 Kiaa0437 NM_053099 Q66JL8 Q9Z180 SETBP_MOUSE uc008fsi.1 uc008fsi.2 uc008fsi.3 uc008fsi.4 Interacts with SET. Nucleus Sequence=AAH80865.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function DNA binding nucleus cytosol biological_process nuclear body uc008fsi.1 uc008fsi.2 uc008fsi.3 uc008fsi.4 
ENSMUST00000025439.5 Me2 ENSMUST00000025439.5 malic enzyme 2, NAD(+)-dependent, mitochondrial, transcript variant 2 (from RefSeq NR_157387.1) ENSMUST00000025439.1 ENSMUST00000025439.2 ENSMUST00000025439.3 ENSMUST00000025439.4 MAOM_MOUSE NR_157387 Q3TBM8 Q99KE1 uc008fox.1 uc008fox.2 uc008fox.3 NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate. Reaction=(S)-malate + NAD(+) = CO2 + NADH + pyruvate; Xref=Rhea:RHEA:12653, ChEBI:CHEBI:15361, ChEBI:CHEBI:15589, ChEBI:CHEBI:16526, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.38; Evidence=; Reaction=H(+) + oxaloacetate = CO2 + pyruvate; Xref=Rhea:RHEA:15641, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526; EC=1.1.1.38; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Divalent metal cations. Prefers magnesium or manganese. ; Subject to allosteric activation by fumarate. Homotetramer. Mitochondrion matrix This isoenzyme can also use NADP(+) but is more effective with NAD(+). Belongs to the malic enzymes family. catalytic activity malic enzyme activity malate dehydrogenase (decarboxylating) (NAD+) activity malate dehydrogenase (decarboxylating) (NADP+) activity mitochondrion mitochondrial matrix pyruvate metabolic process malate metabolic process metabolic process oxaloacetate decarboxylase activity oxidoreductase activity metal ion binding NAD binding oxidation-reduction process regulation of NADP metabolic process uc008fox.1 uc008fox.2 uc008fox.3 
ENSMUST00000025444.8 Cxxc1 ENSMUST00000025444.8 CXXC finger protein 1, transcript variant 1 (from RefSeq NM_028868.3) CXXC1_MOUSE Cgbp ENSMUST00000025444.1 ENSMUST00000025444.2 ENSMUST00000025444.3 ENSMUST00000025444.4 ENSMUST00000025444.5 ENSMUST00000025444.6 ENSMUST00000025444.7 NM_028868 Pccx1 Q9CWW7 uc008fpg.1 uc008fpg.2 uc008fpg.3 uc008fpg.4 Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with SETD1A (By similarity). Interacts with ZNF335 (By similarity). Interacts with PRDM9; this interaction does not link PRDM9-activated recombination hotspot sites with DSB machinery and is not required for the hotspot recognition pathway (PubMed:27932493, PubMed:30365547). Interacts with histone H3K4me3 (PubMed:30365547). Nucleus speckle Nucleus Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes (By similarity). Expressed in seminiferous tubules and in both germ cells and Sertoli cells. Highly expressed in spermatogonia, weakly expressed in leptonema and zygonema, and then again high expression in pachynema and diplonema, decreasing to undetectable levels in spermatids. Cxxc1 knockout male mice are fertile. In contrast Cxxc1 germ cell-specific knockout female mice are sterile. core promoter proximal region sequence-specific DNA binding DNA binding protein binding nucleus cytosol regulation of transcription, DNA-templated zinc ion binding nuclear matrix nuclear speck histone methyltransferase complex histone methyltransferase activity (H3-K4 specific) unmethylated CpG binding positive regulation of transcription, DNA-templated metal ion binding Set1C/COMPASS complex histone H3-K4 methylation uc008fpg.1 uc008fpg.2 uc008fpg.3 uc008fpg.4 
ENSMUST00000025462.7 Rbfa ENSMUST00000025462.7 ribosome binding factor A (from RefSeq NM_199197.2) ENSMUST00000025462.1 ENSMUST00000025462.2 ENSMUST00000025462.3 ENSMUST00000025462.4 ENSMUST00000025462.5 ENSMUST00000025462.6 NM_199197 Q6P3B9 RBFA_MOUSE uc008fsm.1 uc008fsm.2 uc008fsm.3 Mitochondrion Belongs to the RbfA family. molecular_function cellular_component mitochondrion rRNA processing uc008fsm.1 uc008fsm.2 uc008fsm.3 
ENSMUST00000025468.15 Pde6a ENSMUST00000025468.15 phosphodiesterase 6A, cGMP-specific, rod, alpha (from RefSeq NM_146086.3) ENSMUST00000025468.1 ENSMUST00000025468.10 ENSMUST00000025468.11 ENSMUST00000025468.12 ENSMUST00000025468.13 ENSMUST00000025468.14 ENSMUST00000025468.2 ENSMUST00000025468.3 ENSMUST00000025468.4 ENSMUST00000025468.5 ENSMUST00000025468.6 ENSMUST00000025468.7 ENSMUST00000025468.8 ENSMUST00000025468.9 NM_146086 Pde6a Q8K0A8 Q8K0A8_MOUSE uc008fbv.1 uc008fbv.2 uc008fbv.3 uc008fbv.4 uc008fbv.5 Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Belongs to the cyclic nucleotide phosphodiesterase family. 3',5'-cyclic-nucleotide phosphodiesterase activity cell signal transduction G-protein coupled receptor signaling pathway visual perception phosphoric diester hydrolase activity hydrolase activity metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity regulation of cytosolic calcium ion concentration uc008fbv.1 uc008fbv.2 uc008fbv.3 uc008fbv.4 uc008fbv.5 
ENSMUST00000025471.4 Il17b ENSMUST00000025471.4 interleukin 17B (from RefSeq NM_019508.1) ENSMUST00000025471.1 ENSMUST00000025471.2 ENSMUST00000025471.3 IL17B_MOUSE NM_019508 Nirf Q99MY3 Q9CTI4 Q9QXT6 Zcyto7 uc008fcl.1 uc008fcl.2 uc008fcl.3 Stimulates the release of tumor necrosis factor alpha and IL- 1-beta from the monocytic cell line THP-1. Secreted. Belongs to the IL-17 family. receptor binding cytokine activity extracellular region extracellular space inflammatory response signal transduction neutrophil chemotaxis positive regulation of cytokine production involved in inflammatory response uc008fcl.1 uc008fcl.2 uc008fcl.3 
ENSMUST00000025472.7 Pcyox1l ENSMUST00000025472.7 prenylcysteine oxidase 1 like, transcript variant 1 (from RefSeq NM_172832.5) ENSMUST00000025472.1 ENSMUST00000025472.2 ENSMUST00000025472.3 ENSMUST00000025472.4 ENSMUST00000025472.5 ENSMUST00000025472.6 NM_172832 PCYXL_MOUSE Q8C7K6 uc008fcm.1 uc008fcm.2 Probable oxidoreductase. Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Secreted Belongs to the prenylcysteine oxidase family. prenylcysteine oxidase activity extracellular region oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor prenylated protein catabolic process prenylcysteine catabolic process oxidation-reduction process uc008fcm.1 uc008fcm.2 
ENSMUST00000025474.14 Napg ENSMUST00000025474.14 N-ethylmaleimide sensitive fusion protein attachment protein gamma, transcript variant 1 (from RefSeq NM_028017.2) ENSMUST00000025474.1 ENSMUST00000025474.10 ENSMUST00000025474.11 ENSMUST00000025474.12 ENSMUST00000025474.13 ENSMUST00000025474.2 ENSMUST00000025474.3 ENSMUST00000025474.4 ENSMUST00000025474.5 ENSMUST00000025474.6 ENSMUST00000025474.7 ENSMUST00000025474.8 ENSMUST00000025474.9 NM_028017 Napg Q3TPT4 Q9CWZ7 SNAG_MOUSE Snapg uc008fdp.1 uc008fdp.2 uc008fdp.3 uc008fdp.4 uc008fdp.5 uc008fdp.6 Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Interacts with RAB11FIP5 (By similarity). Interacts with VTI1A (PubMed:9705316). Membrane ; Peripheral membrane protein Golgi apparatus Abundantly expressed in the heart, liver and kidneys with lower expression in the brain, spleen, lung, muscle and testes. Belongs to the SNAP family. soluble NSF attachment protein activity mitochondrion vacuolar membrane intracellular protein transport protein transport membrane vesicle-mediated transport syntaxin binding SNARE complex myelin sheath synapse uc008fdp.1 uc008fdp.2 uc008fdp.3 uc008fdp.4 uc008fdp.5 uc008fdp.6 
ENSMUST00000025477.15 St8sia3 ENSMUST00000025477.15 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 (from RefSeq NM_009182.3) ENSMUST00000025477.1 ENSMUST00000025477.10 ENSMUST00000025477.11 ENSMUST00000025477.12 ENSMUST00000025477.13 ENSMUST00000025477.14 ENSMUST00000025477.2 ENSMUST00000025477.3 ENSMUST00000025477.4 ENSMUST00000025477.5 ENSMUST00000025477.6 ENSMUST00000025477.7 ENSMUST00000025477.8 ENSMUST00000025477.9 NM_009182 Q64689 Q6DIB7 SIA8C_MOUSE Siat8c uc008fed.1 uc008fed.2 uc008fed.3 uc008fed.4 Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid. Protein modification; protein glycosylation. Homodimer. Golgi apparatus membrane ; Single- pass type II membrane protein Expressed in brain and testes. Expressed first in 20 dpc fetal brain and decreases thereafter during development. Belongs to the glycosyltransferase 29 family. Name=Functional Glycomics Gateway - GTase; Note=ST8Sia III; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_658"; Golgi membrane ganglioside biosynthetic process alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Golgi apparatus protein glycosylation N-glycan processing sialyltransferase activity glycoprotein metabolic process oligosaccharide metabolic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups identical protein binding protein sialylation uc008fed.1 uc008fed.2 uc008fed.3 uc008fed.4 
ENSMUST00000025482.10 Atp8b1 ENSMUST00000025482.10 ATPase, class I, type 8B, member 1 (from RefSeq NM_001001488.3) AT8B1_MOUSE Atp8b1 ENSMUST00000025482.1 ENSMUST00000025482.2 ENSMUST00000025482.3 ENSMUST00000025482.4 ENSMUST00000025482.5 ENSMUST00000025482.6 ENSMUST00000025482.7 ENSMUST00000025482.8 ENSMUST00000025482.9 NM_001001488 Q148W0 Q3U010 Q6R964 uc008fem.1 uc008fem.2 uc008fem.3 Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (By similarity). May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (PubMed:21820390). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (PubMed:14976163, PubMed:21820390, PubMed:20126555). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity (By similarity). Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 (PubMed:26416959). Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (PubMed:26416959). Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine (By similarity). Required for the preservation of cochlear hair cells in the inner ear (PubMed:19478059). According PubMed:20852622 is proposed to act as cardiolipin transporter during inflammatory injury; the function is questioned by PubMed:21475228 (PubMed:20852622, PubMed:21475228). Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38583, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57643, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38584; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38567, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57262, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38568; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP8B1 and an accessory beta subunit TMEM30A (PubMed:30018401). The flippase ATP8B1:TMEM30A complex can form an intermediate phosphoenzyme in vitro. Also interacts with beta subunit TMEM30B. Cell membrane ; Multi-pass membrane protein Apical cell membrane Cell projection, stereocilium Endoplasmic reticulum Golgi apparatus Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A or TMEM30B. Localizes to apical membranes in epithelial cells. Hepatocytes, bile duct, intestinal epithelial cells (cholangiocytes and ileocytes), and pancreatic acinar cells. Mice have unimpaired bile secretion, and no liver damage, but show mild abnormalities including depressed weight at weaning and elevated serum bile salt levels. Do not suffer from jaundice or diarrhea and have normal serum bilirubin levels and normal liver enzyme activities, except for mildly elevated serum AST (aspartate aminotransferase) activity. Display unimpaired transhepatic bile salt transport and are resistant to bile salt-induced cholestasis. Upon bile salt feeding, demonstrate serum bile salt accumulation, hepatic injury and expansion of the systemic bile salt pool and this failure of bile salt homeostasis occurs in the absence of any defect in hepatic bile secretion (PubMed:14976163). Mutant mice with B6 background show greater abnormalities than 129 and/or F1 background ones. Pups of B6 background gain less weight. In adult B6 background has lower serum cholesterol levels, higher serum alkaline phosphatase levels, and larger livers. After challenge with cholate-supplemented diet, these mice exhibit higher serum alkaline phosphatase and bilirubin levels, greater weight loss and larger livers (PubMed:20126555). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. nucleotide binding magnesium ion binding lipid transporter activity ATP binding endoplasmic reticulum Golgi apparatus plasma membrane drug transmembrane transport lipid transport Golgi organization sensory perception of sound bile acid metabolic process aminophospholipid transporter activity phospholipid transport aminophospholipid transport membrane integral component of membrane apical plasma membrane vestibulocochlear nerve formation brush border membrane stereocilium regulation of microvillus assembly cell projection phospholipid translocation negative regulation of transcription, DNA-templated metal ion binding inner ear receptor cell development cardiolipin binding uc008fem.1 uc008fem.2 uc008fem.3 
ENSMUST00000025486.9 Lmnb1 ENSMUST00000025486.9 lamin B1 (from RefSeq NM_010721.2) ENSMUST00000025486.1 ENSMUST00000025486.2 ENSMUST00000025486.3 ENSMUST00000025486.4 ENSMUST00000025486.5 ENSMUST00000025486.6 ENSMUST00000025486.7 ENSMUST00000025486.8 LMNB1_MOUSE NM_010721 P14733 Q61791 uc012bdd.1 uc012bdd.2 uc012bdd.3 Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Homodimer. Interacts with lamin-associated polypeptides IA, IB and 2. Interacts with SPAG4 and SEPT12 (By similarity). Nucleus lamina B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. Belongs to the intermediate filament family. double-stranded DNA binding nucleus nuclear envelope nuclear inner membrane lamin filament nuclear lamina nucleoplasm cytoplasm intermediate filament JUN kinase binding positive regulation of G2/M transition of mitotic cell cycle membrane nuclear matrix nuclear membrane phospholipase binding positive regulation of JNK cascade cellular response to monosodium L-glutamate sequence-specific double-stranded DNA binding uc012bdd.1 uc012bdd.2 uc012bdd.3 
ENSMUST00000025488.15 C330018D20Rik ENSMUST00000025488.15 RIKEN cDNA C330018D20 gene (from RefSeq NM_029909.1) ENSMUST00000025488.1 ENSMUST00000025488.10 ENSMUST00000025488.11 ENSMUST00000025488.12 ENSMUST00000025488.13 ENSMUST00000025488.14 ENSMUST00000025488.2 ENSMUST00000025488.3 ENSMUST00000025488.4 ENSMUST00000025488.5 ENSMUST00000025488.6 ENSMUST00000025488.7 ENSMUST00000025488.8 ENSMUST00000025488.9 NM_029909 Q9CWB7 YD286_MOUSE uc008eyy.1 uc008eyy.2 uc008eyy.3 uc008eyy.4 uc008eyy.5 Belongs to the glutaredoxin family. YDR286C subfamily. molecular_function mitochondrion biological_process oxidation-reduction process uc008eyy.1 uc008eyy.2 uc008eyy.3 uc008eyy.4 uc008eyy.5 
ENSMUST00000025490.10 Prrc1 ENSMUST00000025490.10 proline-rich coiled-coil 1 (from RefSeq NM_028447.3) ENSMUST00000025490.1 ENSMUST00000025490.2 ENSMUST00000025490.3 ENSMUST00000025490.4 ENSMUST00000025490.5 ENSMUST00000025490.6 ENSMUST00000025490.7 ENSMUST00000025490.8 ENSMUST00000025490.9 NM_028447 PRRC1_MOUSE Q3UPH1 Q91YT1 uc008ezb.1 uc008ezb.2 uc008ezb.3 uc008ezb.4 Golgi apparatus Belongs to the PRRC1 family. Sequence=AAH14817.1; Type=Erroneous initiation; Evidence=; cytoplasm Golgi apparatus activation of protein kinase A activity protein kinase A regulatory subunit binding uc008ezb.1 uc008ezb.2 uc008ezb.3 uc008ezb.4 
ENSMUST00000025497.8 Fbn2 ENSMUST00000025497.8 fibrillin 2 (from RefSeq NM_010181.2) E9QJZ4 ENSMUST00000025497.1 ENSMUST00000025497.2 ENSMUST00000025497.3 ENSMUST00000025497.4 ENSMUST00000025497.5 ENSMUST00000025497.6 ENSMUST00000025497.7 FBN2_MOUSE Fbn-2 Fbn2 NM_010181 Q61555 Q63957 uc008ezn.1 uc008ezn.2 uc008ezn.3 [Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles (PubMed:20855508). Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (PubMed:20855508). [Placensin]: Hormone secreted by trophoblasts that promotes trophoblast invasiveness (By similarity). Has glucogenic activity: is able to increase plasma glucose levels (PubMed:32329225). Interacts with BMP2, BMP4, BMP7, BMP10 and GDF5. Interacts with MFAP2 and MFAP5. Interacts with ADAMTSL5. Interacts with MFAP4. Secreted Note=Fibrillin-2 and Placensin chains are still linked together during the secretion from cells, but are subsequently separated by furin. [Fibrillin-2]: Secreted, extracellular space, extracellular matrix [Placensin]: Secreted Note=Secreted by placental cells. Widely expressed. Strongly expressed during the first week of osteoblast differentiation. [Placensin]: N-glycosylated. O-glycosylated on serine residues by POGLUT2 and POGLUT3. Limb-patterning defects characterized by bilateral syndactyly due to disorganized matrix (PubMed:11470817). Digit fusion involves both soft and hard tissues and is associated with reduced apoptosis at affected sites (PubMed:11470817). Mice show a well developed and morphologically normal aortic wall (PubMed:16407178). Mice display a low bone mass phenotype that is associated with reduced bone formation (PubMed:20855508). Belongs to the fibrillin family. microfibril extracellular matrix structural constituent calcium ion binding protein binding extracellular region embryonic limb morphogenesis positive regulation of bone mineralization extracellular matrix limb morphogenesis sequestering of TGFbeta in extracellular matrix camera-type eye development positive regulation of osteoblast differentiation embryonic eye morphogenesis bone trabecula formation uc008ezn.1 uc008ezn.2 uc008ezn.3 
ENSMUST00000025500.7 Slc27a6 ENSMUST00000025500.7 solute carrier family 27 (fatty acid transporter), member 6 (from RefSeq NM_001081072.1) Acsvl2 E9Q9W4 ENSMUST00000025500.1 ENSMUST00000025500.2 ENSMUST00000025500.3 ENSMUST00000025500.4 ENSMUST00000025500.5 ENSMUST00000025500.6 Facvl2 Fatp1 NM_001081072 S27A6_MOUSE uc008ezp.1 uc008ezp.2 uc008ezp.3 Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (By similarity). Also functions as an acyl-CoA ligase catalyzing the ATP- dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:15699031). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation such as the heart (By similarity). Reaction=a fatty acid(in) = a fatty acid(out); Xref=Rhea:RHEA:38879, ChEBI:CHEBI:28868; Evidence=; Reaction=hexadecanoate(out) = hexadecanoate(in); Xref=Rhea:RHEA:45256, ChEBI:CHEBI:7896; Evidence=; Reaction=(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)- octadecadienoate(in); Xref=Rhea:RHEA:45264, ChEBI:CHEBI:30245; Evidence=; Reaction=(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in); Xref=Rhea:RHEA:33655, ChEBI:CHEBI:30823; Evidence=; Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537; Evidence=; Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616, ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640; Evidence=; Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl- CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422; Evidence=; Reaction=(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:33607, ChEBI:CHEBI:30616, ChEBI:CHEBI:30823, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33608; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:456215; EC=6.2.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19714; Evidence=; Cell membrane, sarcolemma ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. Belongs to the ATP-dependent AMP-binding enzyme family. long-chain fatty acid metabolic process catalytic activity long-chain fatty acid-CoA ligase activity long-chain fatty acid transporter activity endoplasmic reticulum fatty acid transport long-chain fatty acid transport integral component of membrane very long-chain fatty acid-CoA ligase activity uc008ezp.1 uc008ezp.2 uc008ezp.3 
ENSMUST00000025503.10 Isoc1 ENSMUST00000025503.10 isochorismatase domain containing 1 (from RefSeq NM_025478.3) ENSMUST00000025503.1 ENSMUST00000025503.2 ENSMUST00000025503.3 ENSMUST00000025503.4 ENSMUST00000025503.5 ENSMUST00000025503.6 ENSMUST00000025503.7 ENSMUST00000025503.8 ENSMUST00000025503.9 ISOC1_MOUSE NM_025478 Q3U677 Q91V64 uc008ezq.1 uc008ezq.2 uc008ezq.3 Belongs to the isochorismatase family. molecular_function catalytic activity cytoplasm peroxisome biological_process uc008ezq.1 uc008ezq.2 uc008ezq.3 
ENSMUST00000025505.7 Dctn4 ENSMUST00000025505.7 dynactin 4, transcript variant 1 (from RefSeq NM_026302.4) DCTN4_MOUSE ENSMUST00000025505.1 ENSMUST00000025505.2 ENSMUST00000025505.3 ENSMUST00000025505.4 ENSMUST00000025505.5 ENSMUST00000025505.6 NM_026302 Q8CBY8 Q923A0 Q9D4X0 uc008faj.1 uc008faj.2 uc008faj.3 Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin (By similarity). Interacts with ATP7B, but not ATP7A, in a copper-dependent manner (By similarity). Interacts with ANK2; this interaction is required for localization at costameres (PubMed:19109891). Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, stress fiber Cytoplasm, cell cortex Cytoplasm, myofibril, sarcomere Note=Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (By similarity). Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (By similarity). In skeletal muscles, costamere localization requires the presence of ANK2 (PubMed:19109891). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CBY8-1; Sequence=Displayed; Name=2; IsoId=Q8CBY8-2; Sequence=VSP_013573; Belongs to the dynactin subunit 4 family. kinetochore spindle pole stress fiber cytoplasm centrosome microtubule organizing center cytoskeleton cytoplasmic dynein complex dynactin complex focal adhesion cell cortex sarcomere protein N-terminus binding uc008faj.1 uc008faj.2 uc008faj.3 
ENSMUST00000025506.7 Rbm22 ENSMUST00000025506.7 RNA binding motif protein 22 (from RefSeq NM_025776.2) ENSMUST00000025506.1 ENSMUST00000025506.2 ENSMUST00000025506.3 ENSMUST00000025506.4 ENSMUST00000025506.5 ENSMUST00000025506.6 NM_025776 Q3TJB0 Q8BHS3 Q9CXA0 RBM22_MOUSE uc008fam.1 uc008fam.2 uc008fam.3 Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex. Interacts with PDCD6; the interaction induces translocation of PDCD6 in the cytoplasm. Interacts with PPIL1 (By similarity). Nucleus Cytoplasm Note=Nearly exclusively nuclear. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol. The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding. Belongs to the SLT11 family. mRNA splicing, via spliceosome Prp19 complex nucleic acid binding RNA binding nucleus spliceosomal complex cytoplasm mRNA processing RNA splicing U6 snRNA binding positive regulation of RNA splicing cellular response to drug pre-mRNA binding positive regulation of protein import into nucleus mRNA cis splicing, via spliceosome positive regulation of protein export from nucleus metal ion binding calcium-dependent protein binding U2-type catalytic step 1 spliceosome U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome uc008fam.1 uc008fam.2 uc008fam.3 
ENSMUST00000025515.7 Tmx3 ENSMUST00000025515.7 thioredoxin-related transmembrane protein 3 (from RefSeq NM_198295.3) ENSMUST00000025515.1 ENSMUST00000025515.2 ENSMUST00000025515.3 ENSMUST00000025515.4 ENSMUST00000025515.5 ENSMUST00000025515.6 Kiaa1830 NM_198295 Q3US84 Q6PGA1 Q6ZPH5 Q8BXZ1 Q8BZB8 TMX3_MOUSE Txndc10 uc008fvv.1 uc008fvv.2 Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals. Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; Evidence=; Endoplasmic reticulum membrane ; Single-pass membrane protein The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins. Belongs to the protein disulfide isomerase family. Sequence=BAC98261.1; Type=Erroneous initiation; Evidence=; Sequence=BC057139; Type=Frameshift; Evidence=; protein disulfide isomerase activity endoplasmic reticulum endoplasmic reticulum membrane cell surface membrane integral component of membrane isomerase activity thiol oxidase activity peptidyl-cysteine oxidation cell redox homeostasis uc008fvv.1 uc008fvv.2 
ENSMUST00000025520.10 Slc6a7 ENSMUST00000025520.10 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7, transcript variant 1 (from RefSeq NM_201353.2) ENSMUST00000025520.1 ENSMUST00000025520.2 ENSMUST00000025520.3 ENSMUST00000025520.4 ENSMUST00000025520.5 ENSMUST00000025520.6 ENSMUST00000025520.7 ENSMUST00000025520.8 ENSMUST00000025520.9 NM_201353 Q6PGE7 Q80UM1 SC6A7_MOUSE Slc6a7 uc008fbi.1 uc008fbi.2 uc008fbi.3 uc008fbi.4 Brain specific sodium (and chloride)-dependent proline transporter. Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals. Reaction=chloride(out) + L-proline(out) + 2 Na(+)(out) = chloride(in) + L-proline(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71263, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:60039; Evidence=; Reaction=chloride(out) + L-pipecolate(out) + 2 Na(+)(out) = chloride(in) + L-pipecolate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71267, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:61185; Evidence=; Synaptic cell membrane ; Multi-pass membrane protein Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A7 subfamily. neurotransmitter:sodium symporter activity plasma membrane neurotransmitter transport amino acid transport L-proline transmembrane transporter activity symporter activity membrane integral component of membrane proline transmembrane transport uc008fbi.1 uc008fbi.2 uc008fbi.3 uc008fbi.4 
ENSMUST00000025521.9 Cdx1 ENSMUST00000025521.9 caudal type homeobox 1 (from RefSeq NM_009880.4) CDX1_MOUSE Cdx-1 ENSMUST00000025521.1 ENSMUST00000025521.2 ENSMUST00000025521.3 ENSMUST00000025521.4 ENSMUST00000025521.5 ENSMUST00000025521.6 ENSMUST00000025521.7 ENSMUST00000025521.8 NM_009880 P18111 Q8VCF7 uc008fbj.1 uc008fbj.2 uc008fbj.3 Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA. P18111; P20226: TBP; Xeno; NbExp=5; IntAct=EBI-21005290, EBI-355371; Nucleus. Intestinal epithelium. Belongs to the Caudal homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development pattern specification process methyl-CpG binding anterior/posterior axis specification anterior/posterior pattern specification regulation of somitogenesis cell differentiation sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter bone morphogenesis uc008fbj.1 uc008fbj.2 uc008fbj.3 
ENSMUST00000025522.11 Pdgfrb ENSMUST00000025522.11 platelet derived growth factor receptor, beta polypeptide, transcript variant 1 (from RefSeq NM_001146268.1) E9QPE2 ENSMUST00000025522.1 ENSMUST00000025522.10 ENSMUST00000025522.2 ENSMUST00000025522.3 ENSMUST00000025522.4 ENSMUST00000025522.5 ENSMUST00000025522.6 ENSMUST00000025522.7 ENSMUST00000025522.8 ENSMUST00000025522.9 NM_001146268 P05622 PGFRB_MOUSE Pdgfr Pdgfr1 uc008fbl.1 uc008fbl.2 uc008fbl.3 uc008fbl.4 Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM (By similarity). Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence= Present in an inactive conformation in the absence of bound ligand. Binding of PDGFB and/or PDGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB. May also interact with homodimeric PDGFC. Monomer in the absence of bound ligand. Interaction with homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD, leads to receptor dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts with SH2B2/APS. Interacts directly (tyrosine phosphorylated) with SHB. Interacts (tyrosine phosphorylated) with PIK3R1 and RASA1. Interacts (tyrosine phosphorylated) with CBL. Interacts (tyrosine phosphorylated) with SRC and SRC family kinases. Interacts (tyrosine phosphorylated) with PIK3C2B, maybe indirectly. Interacts (tyrosine phosphorylated) with SHC1, GRB7, GRB10 and NCK1. Interaction with GRB2 is mediated by SHC1. Interacts (via C-terminus) with NHERF1 (By similarity). P05622; P39688: Fyn; NbExp=3; IntAct=EBI-1554855, EBI-524514; P05622; Q9JHL1: Nherf2; NbExp=2; IntAct=EBI-1554855, EBI-538451; P05622; Q91YD9: Wasl; NbExp=2; IntAct=EBI-1554855, EBI-642417; P05622; C5IAU5: E5; Xeno; NbExp=2; IntAct=EBI-1554855, EBI-15646370; P05622; P18031: PTPN1; Xeno; NbExp=3; IntAct=EBI-1554855, EBI-968788; Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle Lysosome lumen Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P05622-1; Sequence=Displayed; Name=2; IsoId=P05622-2; Sequence=VSP_060195; Weakly expressed in glomerular mesangial cells and interstitial cells. Up-regulated in areas of renal fibrosis. In mice with unilateral ureteral obstruction, increased expression in interstitial cells at day 4 and expression is markedly elevated at day 7 and is maximal at day 14. Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-578, and to a lesser degree, Tyr-580 is important for interaction with SRC. Phosphorylation at Tyr-715 is important for interaction with GRB2. Phosphorylation at Tyr-739 and Tyr-750 is important for interaction with PIK3R1. Phosphorylation at Tyr-750 is important for interaction with NCK1. Phosphorylation at Tyr- 770 and Tyr-856 is important for interaction with RASA1/GAP. Phosphorylation at Tyr-856 is important for efficient phosphorylation of PLCG1 and PTPN11, resulting in increased phosphorylation of AKT1, MAPK1/ERK2 and/or MAPK3/ERK1, PDCD6IP/ALIX and STAM, and in increased cell proliferation. Phosphorylation at Tyr-1008 is important for interaction with PTPN11. Phosphorylation at Tyr-1008 and Tyr-1020 is important for interaction with PLCG1. Dephosphorylated by PTPRJ at Tyr- 750, Tyr-856, Tyr-1008 and Tyr-1020 (By similarity). Dephosphorylated by PTPN2 at Tyr-578 and Tyr-1020. N-glycosylated. Ubiquitinated. After autophosphorylation, the receptor is polyubiquitinated, leading to its degradation. No apparent phenotype up to 16 dpc. Lethality late during gestation or at birth, due to widespread bleedings. This is due to a severe shortage of vascular smooth muscle cells and pericytes, especially in the central nervous system, skin, lung and heart. Mutants suffer from hemorrhages, anemia, thrombocytopenia, and show defects in the formation of kidney glomeruli, due to a lack of mesangial cells. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. nucleotide binding blood vessel development in utero embryonic development kidney development tissue homeostasis hematopoietic progenitor cell differentiation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity platelet-derived growth factor-activated receptor activity platelet-derived growth factor beta-receptor activity receptor binding platelet-derived growth factor receptor binding protein binding ATP binding nucleus cytoplasm lysosome Golgi apparatus plasma membrane integral component of plasma membrane glycosaminoglycan biosynthetic process protein phosphorylation nitrogen compound metabolic process chemotaxis signal transduction transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development positive regulation of cell proliferation cell surface positive regulation of phospholipase C activity positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of smooth muscle cell migration membrane integral component of membrane kinase activity phosphorylation apical plasma membrane cell migration transferase activity peptidyl-tyrosine phosphorylation enzyme binding protein kinase binding adrenal gland development positive regulation of cell migration intrinsic component of plasma membrane cytoplasmic vesicle positive regulation of phosphoprotein phosphatase activity regulation of actin cytoskeleton organization positive regulation of collagen biosynthetic process positive regulation of Rho protein signal transduction cell migration involved in vasculogenesis intracellular signal transduction metanephric mesenchymal cell migration platelet-derived growth factor receptor-beta signaling pathway positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway aorta morphogenesis cellular response to platelet-derived growth factor stimulus vascular endothelial growth factor binding positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway positive regulation of apoptotic process negative regulation of apoptotic process lysosomal lumen intracellular membrane-bounded organelle receptor complex positive regulation of MAP kinase activity phosphatidylinositol 3-kinase binding positive regulation of phosphatidylinositol 3-kinase activity positive regulation of mitotic nuclear division phosphatidylinositol metabolic process protein autophosphorylation platelet-derived growth factor receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of fibroblast proliferation platelet-derived growth factor binding embryonic organ development positive regulation of smooth muscle cell proliferation skeletal system morphogenesis smooth muscle tissue development regulation of peptidyl-tyrosine phosphorylation positive regulation of chemotaxis cardiac myofibril assembly cell chemotaxis lung growth cardiac vascular smooth muscle cell differentiation cell migration involved in coronary angiogenesis retina vasculature development in camera-type eye cellular response to hydrogen peroxide positive regulation of ERK1 and ERK2 cascade smooth muscle cell chemotaxis metanephric glomerular mesangium development metanephric glomerular mesangial cell proliferation involved in metanephros development metanephric glomerular capillary formation positive regulation of calcium ion import positive regulation of reactive oxygen species metabolic process positive regulation of hepatic stellate cell activation positive regulation of DNA biosynthetic process hemopoiesis uc008fbl.1 uc008fbl.2 uc008fbl.3 uc008fbl.4 
ENSMUST00000025541.6 Gnaq ENSMUST00000025541.6 guanine nucleotide binding protein, alpha q polypeptide (from RefSeq NM_008139.6) ENSMUST00000025541.1 ENSMUST00000025541.2 ENSMUST00000025541.3 ENSMUST00000025541.4 ENSMUST00000025541.5 Gnaq NM_008139 Q3UHH5 Q3UHH5_MOUSE uc008gwt.1 uc008gwt.2 uc008gwt.3 Cell membrane ; Lipid-anchor Golgi apparatus Nucleus membrane Belongs to the G-alpha family. G(q) subfamily. nucleotide binding G-protein coupled receptor binding GTPase activity GTP binding signal transduction G-protein coupled receptor signaling pathway guanyl nucleotide binding G-protein beta/gamma-subunit complex binding uc008gwt.1 uc008gwt.2 uc008gwt.3 
ENSMUST00000025542.10 Psat1 ENSMUST00000025542.10 phosphoserine aminotransferase 1, transcript variant 1 (from RefSeq NM_177420.2) ENSMUST00000025542.1 ENSMUST00000025542.2 ENSMUST00000025542.3 ENSMUST00000025542.4 ENSMUST00000025542.5 ENSMUST00000025542.6 ENSMUST00000025542.7 ENSMUST00000025542.8 ENSMUST00000025542.9 NM_177420 Psa Psat Psat1 Q99K85 SERC_MOUSE uc008gwp.1 uc008gwp.2 uc008gwp.3 uc008gwp.4 Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3- phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3- phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. Reaction=2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate; Xref=Rhea:RHEA:14329, ChEBI:CHEBI:16810, ChEBI:CHEBI:18110, ChEBI:CHEBI:29985, ChEBI:CHEBI:57524; EC=2.6.1.52; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Note=Binds 2 pyridoxal phosphate molecules per dimer, each cofactor is bound at the monomer-monomer interface and forms contacts with residues from both chains. ; Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. Homodimer. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. catalytic activity O-phospho-L-serine:2-oxoglutarate aminotransferase activity cytosol L-serine biosynthetic process transaminase activity cellular amino acid biosynthetic process transferase activity uc008gwp.1 uc008gwp.2 uc008gwp.3 uc008gwp.4 
ENSMUST00000025546.17 Cndp2 ENSMUST00000025546.17 CNDP dipeptidase 2, transcript variant 2 (from RefSeq NM_023149.3) CNDP2_MOUSE Cn2 ENSMUST00000025546.1 ENSMUST00000025546.10 ENSMUST00000025546.11 ENSMUST00000025546.12 ENSMUST00000025546.13 ENSMUST00000025546.14 ENSMUST00000025546.15 ENSMUST00000025546.16 ENSMUST00000025546.2 ENSMUST00000025546.3 ENSMUST00000025546.4 ENSMUST00000025546.5 ENSMUST00000025546.6 ENSMUST00000025546.7 ENSMUST00000025546.8 ENSMUST00000025546.9 NM_023149 Q3TA80 Q3TI32 Q3U7B9 Q99PV1 Q9D1A2 uc008fuu.1 uc008fuu.2 uc008fuu.3 uc008fuu.4 uc008fuu.5 Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides (PubMed:31587987). Mediates threonyl dipeptide catabolism in a tissue- specific way (PubMed:31587987). Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism (By similarity). Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis (By similarity). Plays a role in the regulation of cell cycle arrest and apoptosis (By similarity). Reaction=Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.; EC=3.4.13.18; Evidence=; Reaction=H2O + L-threonyl-L-threonine = 2 L-threonine; Xref=Rhea:RHEA:67360, ChEBI:CHEBI:15377, ChEBI:CHEBI:57926, ChEBI:CHEBI:169953; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67361; Evidence=; Reaction=H2O + L-threonyl-L-serine = L-serine + L-threonine; Xref=Rhea:RHEA:67364, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384, ChEBI:CHEBI:57926, ChEBI:CHEBI:169954; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67365; Evidence=; Reaction=H2O + L-seryl-L-threonine = L-serine + L-threonine; Xref=Rhea:RHEA:67372, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384, ChEBI:CHEBI:57926, ChEBI:CHEBI:169955; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67373; Evidence=; Reaction=H2O + L-cysteinylglycine = glycine + L-cysteine; Xref=Rhea:RHEA:28783, ChEBI:CHEBI:15377, ChEBI:CHEBI:35235, ChEBI:CHEBI:57305, ChEBI:CHEBI:61694; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28784; Evidence=; Reaction=H2O + L-alanyl-L-cysteine = L-alanine + L-cysteine; Xref=Rhea:RHEA:67380, ChEBI:CHEBI:15377, ChEBI:CHEBI:35235, ChEBI:CHEBI:57972, ChEBI:CHEBI:169958; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67381; Evidence=; Reaction=(S)-lactate + L-phenylalanine = H2O + N-[(S)-lactoyl]-L- phenylalanine; Xref=Rhea:RHEA:66724, ChEBI:CHEBI:15377, ChEBI:CHEBI:16651, ChEBI:CHEBI:58095, ChEBI:CHEBI:167456; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66725; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:66726; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. Inhibited by bestatin. Homodimer. Cytoplasm Highly expressed in the parafascicular nucleus of the thalamus, tuberomammillary nucleus of the hypothalamus and the mitral cell layer of the olfactory bulb. Belongs to the peptidase M20A family. carboxypeptidase activity nucleoplasm cytoplasm cytosol proteolysis peptidase activity metallopeptidase activity hydrolase activity dipeptidase activity metal ion binding cytosolic dipeptidase activity uc008fuu.1 uc008fuu.2 uc008fuu.3 uc008fuu.4 uc008fuu.5 
ENSMUST00000025547.4 Timm21 ENSMUST00000025547.4 translocase of inner mitochondrial membrane 21, transcript variant 2 (from RefSeq NR_160856.1) ENSMUST00000025547.1 ENSMUST00000025547.2 ENSMUST00000025547.3 NR_160856 Q3THX0 Q8CCM6 Q8CE44 Q9CYU8 Q9CZS4 TIM21_MOUSE Tim21 uc008fuy.1 uc008fuy.2 uc008fuy.3 Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. Component of the TIM23 complex. Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14. Interacts with COA3 and MT- CO1/COX1. Mitochondrion membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CCM6-2; Sequence=Displayed; Name=2; IsoId=Q8CCM6-3; Sequence=VSP_060547, VSP_060548; Belongs to the TIM21 family. Sequence=BAC27885.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; molecular_function mitochondrion mitochondrial inner membrane presequence translocase complex protein transport membrane integral component of membrane protein import into mitochondrial matrix mitochondrial membrane mitochondrial respiratory chain complex I assembly mitochondrial respiratory chain complex IV assembly uc008fuy.1 uc008fuy.2 uc008fuy.3 
ENSMUST00000025554.3 Scgb1a1 ENSMUST00000025554.3 secretoglobin, family 1A, member 1 (from RefSeq NM_011681.2) ENSMUST00000025554.1 ENSMUST00000025554.2 NM_011681 Q3UKV9 Q3UKV9_MOUSE Scgb1a1 uc008gom.1 uc008gom.2 uc008gom.3 Secreted Belongs to the secretoglobin family. extracellular space nuclear envelope cytoplasm endoplasmic reticulum rough endoplasmic reticulum signal transduction response to xenobiotic stimulus response to organic substance response to ozone secretory granule response to lipopolysaccharide response to silicon dioxide response to cytokine response to drug response to glucocorticoid response to fibroblast growth factor polychlorinated biphenyl binding uc008gom.1 uc008gom.2 uc008gom.3 
ENSMUST00000025561.8 Anxa1 ENSMUST00000025561.8 annexin A1 (from RefSeq NM_010730.2) Anxa1 ENSMUST00000025561.1 ENSMUST00000025561.2 ENSMUST00000025561.3 ENSMUST00000025561.4 ENSMUST00000025561.5 ENSMUST00000025561.6 ENSMUST00000025561.7 NM_010730 Q4FJV4 Q4FJV4_MOUSE uc008gyi.1 uc008gyi.2 uc008gyi.3 Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2. Apical cell membrane Basolateral cell membrane Cell membrane ; Peripheral membrane protein ; Extracellular side Cell projection, cilium Cell projection, phagocytic cup Cytoplasmic vesicle membrane ; Peripheral membrane protein Cytoplasmic vesicle, secretory vesicle lumen Early endosome Endosome membrane ; Peripheral membrane protein Lateral cell membrane Membrane ; Peripheral membrane protein Nucleus Secreted, extracellular exosome Secreted, extracellular space The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N- terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding. Belongs to the annexin family. cornified envelope neutrophil homeostasis monocyte chemotaxis single-stranded DNA binding single-stranded RNA binding phospholipase inhibitor activity calcium ion binding phospholipid binding calcium-dependent phospholipid binding extracellular space nucleus nucleoplasm cytoplasm endosome cytosol actin filament plasma membrane cell surface receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger regulation of cell shape response to hormone cell surface response to X-ray response to organic cyclic compound peptide cross-linking phospholipase A2 inhibitor activity extrinsic component of membrane insulin secretion keratinocyte differentiation prostate gland development endocrine pancreas development extrinsic component of external side of plasma membrane positive regulation of vesicle fusion positive regulation of prostaglandin biosynthetic process actin cytoskeleton reorganization response to corticosteroid mitochondrial membrane response to estradiol DNA duplex unwinding positive regulation of interleukin-2 production macromolecular complex cellular response to vascular endothelial growth factor stimulus gliogenesis positive regulation of T cell proliferation response to drug mast cell granule protein homodimerization activity positive regulation of apoptotic process response to peptide hormone estrous cycle positive regulation of T-helper 1 cell differentiation negative regulation of T-helper 2 cell differentiation negative regulation of exocytosis regulation of hormone secretion calcium-dependent protein binding negative regulation of protein secretion response to glucocorticoid extracellular exosome cellular response to hydrogen peroxide hepatocyte differentiation prolactin secretion response to interleukin-1 cellular response to glucocorticoid stimulus granulocyte chemotaxis positive regulation of cell migration involved in sprouting angiogenesis positive regulation of wound healing synaptic membrane neutrophil clearance negative regulation of phospholipase A2 activity DNA/DNA annealing activity negative regulation of interleukin-8 secretion uc008gyi.1 uc008gyi.2 uc008gyi.3 
ENSMUST00000025562.9 Incenp ENSMUST00000025562.9 inner centromere protein, transcript variant 2 (from RefSeq NM_016692.4) ENSMUST00000025562.1 ENSMUST00000025562.2 ENSMUST00000025562.3 ENSMUST00000025562.4 ENSMUST00000025562.5 ENSMUST00000025562.6 ENSMUST00000025562.7 ENSMUST00000025562.8 INCE_MOUSE NM_016692 Q7TN28 Q8BGN4 Q8CGI4 Q9WU62 uc008gos.1 uc008gos.2 uc008gos.3 uc008gos.4 Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules. The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC. Controls the kinetochore localization of BUB1. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex binds directly to AURKB or AURKC via the IN box, and forms a triple-helix bundle-based subcomplex with BIRC5 and CDCA8 via its N- terminus. The reported homodimerization is questioned as the SAH domain is shown to be monomeric. Interacts with H2AZ1. Interacts with CBX1 and CBX3. Interacts with tubulin beta chain. Interacts with EVI5. Interacts with CBX5; POGZ and INCENP compete for interaction with CBX5. Interacts with POGZ. Interacts with JTB. Chromosome, centromere Cytoplasm, cytoskeleton, spindle Nucleus Chromosome, centromere, kinetochore Midbody Note=Localizes to inner kinetochore. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes to the equatorial cell cortex at anaphase (By similarity). Localized at synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocenters (PubMed:12584241). Colocalizes with AURKB at a connecting strand traversing the centromere region and joining sister kinetochores, in metaphase II centromeres. This strand disappears at the metaphase II/anaphase II transition and relocalizes to the spindle midzone (PubMed:12584241). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=B; IsoId=Q9WU62-1; Sequence=Displayed; Name=2; Synonyms=A; IsoId=Q9WU62-2; Sequence=VSP_007233; The IN box mediates interaction with AURKB and AURKC. The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha- helical structure by ionic bonds. It can refold after extension suggesting an in vivo force-dependent function. The isolated SAH domain is monomeric. Phosphorylation by AURKB at its C-terminal part is important for AURKB activation by INCENP. [Isoform 1]: Major isoform in thymic lymphoma 3SB cells. Fourfold more abundant than isoform 2. [Isoform 2]: Minor isoform in thymic lymphoma 3SB cells. Belongs to the INCENP family. Originally predicted to contain a coiled coil domain but shown to contain a stable SAH domain instead. mitotic sister chromatid segregation mitotic cytokinesis chromosome, centromeric region kinetochore condensed chromosome kinetochore synaptonemal complex lateral element central element nucleus chromosome pericentric heterochromatin cytoplasm spindle cytosol cytoskeleton microtubule cell cycle chromosome segregation chromocenter nuclear body midbody macromolecular complex cell division regulation of mitotic cytokinesis uc008gos.1 uc008gos.2 uc008gos.3 uc008gos.4 
ENSMUST00000025567.9 Fads2 ENSMUST00000025567.9 fatty acid desaturase 2 (from RefSeq NM_019699.2) ENSMUST00000025567.1 ENSMUST00000025567.2 ENSMUST00000025567.3 ENSMUST00000025567.4 ENSMUST00000025567.5 ENSMUST00000025567.6 ENSMUST00000025567.7 ENSMUST00000025567.8 FADS2_MOUSE Fads2 Fadsd2 NM_019699 Q9Z0R9 uc008gpb.1 uc008gpb.2 uc008gpb.3 Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:9867867). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity). Reaction=(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:47140, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57363, ChEBI:CHEBI:57383; EC=1.14.19.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47141; Evidence=; Reaction=(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)- [cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:47144, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:71489, ChEBI:CHEBI:74034; EC=1.14.19.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47145; Evidence=; Reaction=(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)- [cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z,18Z,21Z)- tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:36999, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:74083, ChEBI:CHEBI:74086; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37000; Evidence=; Reaction=(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:46064, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:74296, ChEBI:CHEBI:85652; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46065; Evidence=; Reaction=(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:39567, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:74264, ChEBI:CHEBI:76410; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39568; Evidence=; Reaction=(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)- [cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:39571, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:74265, ChEBI:CHEBI:74328; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39572; Evidence=; Lipid metabolism; polyunsaturated fatty acid biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Highly expressed in the adrenal gland, liver, brain, and testis, tissues where lipogenesis and steroidogenesis are active. Also detected in lung, heart, and skeletal muscle. Found in 13-day-old embryo heart. Induced by dietary PUFA-deficient diet. Induced by a fat- free diet and by a diet containing triolein (18:1n-9) as the only fat source. Down-regulated in liver by dietary PUFA. The protein sequence includes a number of characteristic features of microsomal fatty acid desaturases including the three histidine boxes HXXXH, HXXHH, and QXXHH (these domains may contain the active site and/or be involved in metal ion binding), and the N- terminal cytochrome b5 domain containing the heme-binding motif, HPGG, similar to that of other fatty acid desaturases. Belongs to the fatty acid desaturase type 1 family. stearoyl-CoA 9-desaturase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process membrane integral component of membrane linoleoyl-CoA desaturase activity oxidoreductase activity oxidation-reduction process uc008gpb.1 uc008gpb.2 uc008gpb.3 
ENSMUST00000025568.3 Tmem138 ENSMUST00000025568.3 transmembrane protein 138, transcript variant 3 (from RefSeq NR_126092.1) ENSMUST00000025568.1 ENSMUST00000025568.2 NR_126092 Q9D6G5 Q9D9A8 TM138_MOUSE uc008gqd.1 uc008gqd.2 uc008gqd.3 uc008gqd.4 Required for ciliogenesis. Vacuole membrane ; Multi-pass membrane protein Cell projection, cilium Note=Localizes to vesicles en route to the base of cilium. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D6G5-1; Sequence=Displayed; Name=2; IsoId=Q9D6G5-2; Sequence=VSP_024893, VSP_024894; Belongs to the TMEM138 family. molecular_function vacuole vacuolar membrane cilium membrane integral component of membrane cell projection organization cell projection cilium assembly uc008gqd.1 uc008gqd.2 uc008gqd.3 uc008gqd.4 
ENSMUST00000025570.8 Sdhaf2 ENSMUST00000025570.8 succinate dehydrogenase complex assembly factor 2 (from RefSeq NM_025333.4) ENSMUST00000025570.1 ENSMUST00000025570.2 ENSMUST00000025570.3 ENSMUST00000025570.4 ENSMUST00000025570.5 ENSMUST00000025570.6 ENSMUST00000025570.7 NM_025333 Pgl2 Q3TVE5 Q6PAS5 Q80ZJ9 Q8C6I2 Q8K2W8 Q9CYQ2 SDHF2_MOUSE Sdh5 Sdhaf2 uc008gpt.1 uc008gpt.2 uc008gpt.3 uc008gpt.4 uc008gpt.5 Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. Interacts with SDHA within the SDH catalytic dimer. Mitochondrion matrix Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C6I2-1; Sequence=Displayed; Name=2; IsoId=Q8C6I2-2; Sequence=VSP_026634; Name=3; IsoId=Q8C6I2-3; Sequence=VSP_026633; Belongs to the SDHAF2 family. molecular_function nucleolus mitochondrion mitochondrial matrix cytosol tricarboxylic acid cycle mitochondrial electron transport, succinate to ubiquinone protein dephosphorylation negative regulation of epithelial to mesenchymal transition protein-FAD linkage mitochondrial respiratory chain complex II assembly negative regulation of canonical Wnt signaling pathway uc008gpt.1 uc008gpt.2 uc008gpt.3 uc008gpt.4 uc008gpt.5 
ENSMUST00000025571.9 Cd5 ENSMUST00000025571.9 CD5 antigen (from RefSeq NM_007650.3) Cd5 ENSMUST00000025571.1 ENSMUST00000025571.2 ENSMUST00000025571.3 ENSMUST00000025571.4 ENSMUST00000025571.5 ENSMUST00000025571.6 ENSMUST00000025571.7 ENSMUST00000025571.8 NM_007650 Q3UP78 Q3UP78_MOUSE uc008gqv.1 uc008gqv.2 uc008gqv.3 Lacks conserved residue(s) required for the propagation of feature annotation. scavenger receptor activity plasma membrane endocytosis membrane integral component of membrane uc008gqv.1 uc008gqv.2 uc008gqv.3 
ENSMUST00000025581.7 Ms4a4d ENSMUST00000025581.7 membrane-spanning 4-domains, subfamily A, member 4D (from RefSeq NM_025658.5) ENSMUST00000025581.1 ENSMUST00000025581.2 ENSMUST00000025581.3 ENSMUST00000025581.4 ENSMUST00000025581.5 ENSMUST00000025581.6 M4A4D_MOUSE NM_025658 Q99N05 uc008gsl.1 uc008gsl.2 uc008gsl.3 May be involved in signal transduction as a component of a multimeric receptor complex. Membrane; Multi-pass membrane protein. Expressed in thymus, spleen, peripheral lymph node, liver, kidney, heart, colon, lung, and testes. Belongs to the MS4A family. molecular_function cellular_component biological_process membrane integral component of membrane uc008gsl.1 uc008gsl.2 uc008gsl.3 
ENSMUST00000025582.11 Ms4a6d ENSMUST00000025582.11 membrane-spanning 4-domains, subfamily A, member 6D (from RefSeq NM_026835.3) ENSMUST00000025582.1 ENSMUST00000025582.10 ENSMUST00000025582.2 ENSMUST00000025582.3 ENSMUST00000025582.4 ENSMUST00000025582.5 ENSMUST00000025582.6 ENSMUST00000025582.7 ENSMUST00000025582.8 ENSMUST00000025582.9 Ms4a6d NM_026835 Q2TVW7 Q2TVW7_MOUSE uc008gsm.1 uc008gsm.2 uc008gsm.3 Belongs to the MS4A family. membrane integral component of membrane uc008gsm.1 uc008gsm.2 uc008gsm.3 
ENSMUST00000025585.4 Cblif ENSMUST00000025585.4 cobalamin binding intrinsic factor (from RefSeq NM_008118.3) ENSMUST00000025585.1 ENSMUST00000025585.2 ENSMUST00000025585.3 Gif IF_MOUSE NM_008118 P52787 Q8C5C1 uc008gsw.1 uc008gsw.2 uc008gsw.3 Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). Interacts with CUBN (via CUB domains). Secreted. Gastric mucosa. Belongs to the eukaryotic cobalamin transport proteins family. extracellular region extracellular space endosome microvillus ion transport cobalt ion transport cobalamin metabolic process cobalamin transport apical plasma membrane cobalamin binding uc008gsw.1 uc008gsw.2 uc008gsw.3 
ENSMUST00000025590.11 Osbp ENSMUST00000025590.11 oxysterol binding protein (from RefSeq NM_001033174.1) E9QPD4 ENSMUST00000025590.1 ENSMUST00000025590.10 ENSMUST00000025590.2 ENSMUST00000025590.3 ENSMUST00000025590.4 ENSMUST00000025590.5 ENSMUST00000025590.6 ENSMUST00000025590.7 ENSMUST00000025590.8 ENSMUST00000025590.9 Kiaa4220 NM_001033174 OSBP1_MOUSE Q3B7Z2 Q3V163 Q52KH7 Q570Y8 uc008gtj.1 uc008gtj.2 uc008gtj.3 uc008gtj.4 Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25- hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability. Homodimer or homotrimer. Interacts (via FFAT motif) with VAPA. Interacts (via C-terminus) with RELCH (via the third HEAT repeat) (PubMed:29514919). Found in a complex composed of RELCH, OSBP1 and RAB11A (PubMed:29514919). Cytoplasm, cytosol Cytoplasm, perinuclear region Golgi apparatus membrane ; Peripheral membrane protein Endoplasmic reticulum membrane ; Peripheral membrane protein Note=Predominantly cytosolic. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3B7Z2-1; Sequence=Displayed; Name=2; IsoId=Q3B7Z2-2; Sequence=VSP_035281, VSP_035282; The FFAT motif is required for interaction with VATA and proper localization of the protein. The PH and the Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding. The second coiled-coil domain is required for interaction with the tyrosine phosphatase. Belongs to the OSBP family. Sequence=AAI07328.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=AAI07329.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Golgi membrane protein binding nucleus nucleoplasm nucleolus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus trans-Golgi network cytosol lipid transport lipid binding sterol transport membrane protein domain specific binding cell junction intracellular cholesterol transport sterol binding intracellular membrane-bounded organelle perinuclear region of cytoplasm phosphatidylinositol-4-phosphate binding uc008gtj.1 uc008gtj.2 uc008gtj.3 uc008gtj.4 
ENSMUST00000025598.10 Keg1 ENSMUST00000025598.10 kidney expressed gene 1 (from RefSeq NM_029550.4) ENSMUST00000025598.1 ENSMUST00000025598.2 ENSMUST00000025598.3 ENSMUST00000025598.4 ENSMUST00000025598.5 ENSMUST00000025598.6 ENSMUST00000025598.7 ENSMUST00000025598.8 ENSMUST00000025598.9 KEG1_MOUSE NM_029550 Q9DCY0 uc008gum.1 uc008gum.2 uc008gum.3 uc008gum.4 uc008gum.5 Acyltransferase which transfers the acyl group to the N- terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity). Reaction=an acyl-CoA + glycine = an N-acylglycine + CoA + H(+); Xref=Rhea:RHEA:19869, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57670, ChEBI:CHEBI:58342; EC=2.3.1.13; Binds to microtubules. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Also localizes in regions surrounding the centrosome. The centrosomal localization is dependent on microtubules (By similarity). Belongs to the glycine N-acyltransferase family. cytoplasm mitochondrion centrosome microtubule organizing center cytoskeleton microtubule transferase activity transferase activity, transferring acyl groups glycine N-acyltransferase activity uc008gum.1 uc008gum.2 uc008gum.3 uc008gum.4 uc008gum.5 
ENSMUST00000025601.8 Lpxn ENSMUST00000025601.8 leupaxin, transcript variant 1 (from RefSeq NM_134152.4) ENSMUST00000025601.1 ENSMUST00000025601.2 ENSMUST00000025601.3 ENSMUST00000025601.4 ENSMUST00000025601.5 ENSMUST00000025601.6 ENSMUST00000025601.7 LPXN_MOUSE NM_134152 Q99N69 uc008guq.1 uc008guq.2 uc008guq.3 uc008guq.4 Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. Interacts with unphosphorylated ITGA4. Interacts with AR and SRF (By similarity). Interacts with PTK2B/PYK2, PTPN22 and PTPN12. Interacts (via LD motif 3) with LYN and the interaction is induced upon B-cell antigen receptor (BCR) activation. Interacts (via LD motif 3) with PTK2/FAK. Cytoplasm Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin (By similarity). Expressed in osteoclasts (at protein level). Highly expressed in vascular smooth muscle. The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR. Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-72 (By similarity). Belongs to the paxillin family. podosome transcription cofactor activity protein binding nucleus cytoplasm cytosol plasma membrane focal adhesion cell adhesion negative regulation of cell adhesion membrane nuclear speck cell junction regulation of cell adhesion mediated by integrin cell projection metal ion binding perinuclear region of cytoplasm negative regulation of B cell receptor signaling pathway regulation of nucleic acid-templated transcription uc008guq.1 uc008guq.2 uc008guq.3 uc008guq.4 
ENSMUST00000025602.4 Gna14 ENSMUST00000025602.4 guanine nucleotide binding protein, alpha 14 (from RefSeq NM_008137.4) ENSMUST00000025602.1 ENSMUST00000025602.2 ENSMUST00000025602.3 GNA14_MOUSE Gna-14 NM_008137 P30677 Q8R2X9 uc008gwu.1 uc008gwu.2 uc008gwu.3 uc008gwu.4 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(q) subfamily. nucleotide binding G-protein coupled receptor binding GTPase activity GTP binding heterotrimeric G-protein complex signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway guanyl nucleotide binding G-protein beta/gamma-subunit complex binding metal ion binding phospholipase C-activating dopamine receptor signaling pathway uc008gwu.1 uc008gwu.2 uc008gwu.3 uc008gwu.4 
ENSMUST00000025617.4 Rfk ENSMUST00000025617.4 riboflavin kinase (from RefSeq NM_019437.3) ENSMUST00000025617.1 ENSMUST00000025617.2 ENSMUST00000025617.3 NM_019437 O35471 O35472 Q8CFV9 Q9CQ95 RIFK_MOUSE uc008gxo.1 uc008gxo.2 uc008gxo.3 Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF- activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase (By similarity). Reaction=ATP + riboflavin = ADP + FMN + H(+); Xref=Rhea:RHEA:14357, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57986, ChEBI:CHEBI:58210, ChEBI:CHEBI:456216; EC=2.7.1.26; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14358; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Zinc or magnesium. ; Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1. Monomer (By similarity). Directly interacts with TNFRSF1A death domain; this interaction may be supported by TRADD (PubMed:19641494). In the absence of TNFRSF1A, interacts with TRADD (PubMed:19641494). Independently of TNFRSF1A, interacts with the NADPH oxidase subunit CYBA (PubMed:19641494). Cytoplasm Mutant embryos die in utero before 7.5 dpc. nucleotide binding protein binding ATP binding cytoplasm mitochondrion apoptotic process riboflavin kinase activity riboflavin biosynthetic process FMN biosynthetic process kinase activity phosphorylation transferase activity positive regulation of NAD(P)H oxidase activity metal ion binding reactive oxygen species metabolic process uc008gxo.1 uc008gxo.2 uc008gxo.3 
ENSMUST00000025618.16 Pcsk5 ENSMUST00000025618.16 proprotein convertase subtilisin/kexin type 5, transcript variant 1 (from RefSeq NM_001190483.2) E9QPB7 ENSMUST00000025618.1 ENSMUST00000025618.10 ENSMUST00000025618.11 ENSMUST00000025618.12 ENSMUST00000025618.13 ENSMUST00000025618.14 ENSMUST00000025618.15 ENSMUST00000025618.2 ENSMUST00000025618.3 ENSMUST00000025618.4 ENSMUST00000025618.5 ENSMUST00000025618.6 ENSMUST00000025618.7 ENSMUST00000025618.8 ENSMUST00000025618.9 NM_001190483 PCSK5_MOUSE Q04592 Q62040 uc008gxp.1 uc008gxp.2 uc008gxp.3 uc008gxp.4 uc008gxp.5 uc008gxp.6 This gene encodes a subtilisin-like proprotein convertase that mediates posttranslational endoproteolytic processing of various proprotein substrates traversing the secretory pathway. The encoded protein is an inactive zymogen that undergoes autoproteolytic processing in the endoplasmic reticulum and the Golgi network to generate an active enzyme. Mice lacking the encoded protein die at an early embryonic stage. Conditional inactivation this gene in the epiblast but not in the extraembryonic tissue bypasses embryonic lethality but results in death at birth. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]. Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors. [Isoform PC5A]: Secreted. Note=Secreted through the regulated secretory pathway. [Isoform PC5B]: Endomembrane system; Single-pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes. Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=PC5B; Synonyms=Long; IsoId=Q04592-1; Sequence=Displayed; Name=PC5A; Synonyms=Short; IsoId=Q04592-2; Sequence=VSP_005438, VSP_005439; PC5A is expressed in most tissues but is most abundant in the intestine and adrenals. PC5B is expressed in the intestine, adrenals and lung but not in the brain. Weakly expressed throughout the embryo, except in the developing nervous system, the ribs and the liver, but markedly up- regulated at discrete sites during development. At 6.5 dpc, prominent expression observed in differentiated decidua. At 7.5 dpc, intense expression in extraembryonic endoderm, amnion and nascent mesoderm. At 8.5 dpc, abundant expression in somites and yolk sac followed by a confinement to dermamyotome compartment. Between 9.5 dpc and 11.5 dpc, abundant expression in AER (thickened ectodermal cells of limb buds). At 12.5 dpc, expression in the limbs is confined to the condensing mesenchyme surrounding the cartilage. At this stage, strong expression also detected in vertebral and facial cartilage primordia and in the muscle of the tongue. At 16.5 dpc, abundant expression in epithelial cells of the intestinal villi. Isoform A is most abundant at all stages but significant levels of isoform B occur at 12.5 dpc. The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum. AC 1 and AC 2 (clusters of acidic amino acids) contain sorting information. AC 1 directs TGN localization and interacts with the TGN sorting protein PACS-1. Belongs to the peptidase S8 family. kidney development renin secretion into blood stream cardiac septum development endopeptidase activity serine-type endopeptidase activity extracellular region extracellular space endoplasmic reticulum lumen Golgi apparatus Golgi medial cisterna trans-Golgi network plasma membrane signal peptide processing proteolysis determination of left/right symmetry heart development female pregnancy embryo implantation peptidase activity serine-type peptidase activity anterior/posterior pattern specification endomembrane system membrane integral component of membrane protein processing peptide hormone processing hydrolase activity viral life cycle secretory granule integral component of Golgi membrane respiratory tube development positive regulation of integrin activation limb morphogenesis cytokine biosynthetic process peptide binding peptide biosynthetic process perikaryon embryonic digestive tract development embryonic skeletal system development coronary vasculature development positive regulation of vascular associated smooth muscle cell migration positive regulation of smooth muscle cell-matrix adhesion proximal dendrite positive regulation of integrin-mediated signaling pathway uc008gxp.1 uc008gxp.2 uc008gxp.3 uc008gxp.4 uc008gxp.5 uc008gxp.6 
ENSMUST00000025631.7 Ostf1 ENSMUST00000025631.7 osteoclast stimulating factor 1 (from RefSeq NM_017375.3) ENSMUST00000025631.1 ENSMUST00000025631.2 ENSMUST00000025631.3 ENSMUST00000025631.4 ENSMUST00000025631.5 ENSMUST00000025631.6 NM_017375 OSTF1_MOUSE Q3UF05 Q62422 Sh3d3 Sh3p2 uc008gxs.1 uc008gxs.2 uc008gxs.3 uc008gxs.4 Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity. Interacts with C-SRC and SMN1. Interacts with FASLG (By similarity). Cytoplasm The SH3 domain mediates interaction with SMN1. Sequence=AAC52641.1; Type=Erroneous initiation; Evidence=; cytoplasm biological_process SH3 domain binding uc008gxs.1 uc008gxs.2 uc008gxs.3 uc008gxs.4 
ENSMUST00000025632.11 Carnmt1 ENSMUST00000025632.11 carnosine N-methyltransferase 1, transcript variant 1 (from RefSeq NM_026120.5) CARME_MOUSE Carnmt1 ENSMUST00000025632.1 ENSMUST00000025632.10 ENSMUST00000025632.2 ENSMUST00000025632.3 ENSMUST00000025632.4 ENSMUST00000025632.5 ENSMUST00000025632.6 ENSMUST00000025632.7 ENSMUST00000025632.8 ENSMUST00000025632.9 NM_026120 Q80UY1 Q9CWF3 uc008gxv.1 uc008gxv.2 uc008gxv.3 uc008gxv.4 N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His). Reaction=carnosine + S-adenosyl-L-methionine = anserine + H(+) + S- adenosyl-L-homocysteine; Xref=Rhea:RHEA:14205, ChEBI:CHEBI:15378, ChEBI:CHEBI:57485, ChEBI:CHEBI:57856, ChEBI:CHEBI:58445, ChEBI:CHEBI:59789; EC=2.1.1.22; Evidence=; Homodimer. Each monomer accommodates one molecule of carnosine in its active pocket, precisely anchoring the histidine imidazole ring such that only N1 is exposed and deprotonated for methylation. Cytoplasm, cytosol Nucleus The Gly-Xaa-Gly-Xaa-Gly (GXGXG) motif binds the adenosyl part of S-adenosyl-L-methionine. The carnosine-binding region forms hydrophobic and hydrogen bonds with carnosine, defining a flipping orientation of the imidazole ring so that N1 is present next to S-adenosyl-L-methionine for methylation. Belongs to the carnosine N-methyltransferase family. nucleus cytoplasm cytosol methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity transferase activity carnosine N-methyltransferase activity methylation carnosine metabolic process uc008gxv.1 uc008gxv.2 uc008gxv.3 uc008gxv.4 
ENSMUST00000025635.8 Ms4a20 ENSMUST00000025635.8 membrane-spanning 4-domains, subfamily A, member 20 (from RefSeq NM_027058.1) 1700017D01Rik ENSMUST00000025635.1 ENSMUST00000025635.2 ENSMUST00000025635.3 ENSMUST00000025635.4 ENSMUST00000025635.5 ENSMUST00000025635.6 ENSMUST00000025635.7 G5E851 G5E851_MOUSE Ms4a20 NM_027058 uc008grq.1 uc008grq.2 uc008grq.3 uc008grq.4 molecular_function cellular_component biological_process membrane integral component of membrane uc008grq.1 uc008grq.2 uc008grq.3 uc008grq.4 
ENSMUST00000025636.8 Ms4a8a ENSMUST00000025636.8 membrane-spanning 4-domains, subfamily A, member 8A (from RefSeq NM_022430.2) Cd20l5 ENSMUST00000025636.1 ENSMUST00000025636.2 ENSMUST00000025636.3 ENSMUST00000025636.4 ENSMUST00000025636.5 ENSMUST00000025636.6 ENSMUST00000025636.7 F8WIR2 M4A8_MOUSE Ms4a8 NM_022430 Q2TVW6 Q3T990 Q8CG94 Q99N10 Q9EQZ0 uc008gro.1 uc008gro.2 uc008gro.3 May be involved in signal transduction as a component of a multimeric receptor complex. Membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99N10-3; Sequence=Displayed; Name=2; IsoId=Q99N10-1; Sequence=VSP_053843; Expressed strongly in intestine and colon and minimally in lung and ovary. [Isoform 2]: Not found in strain C57BL/6J but has been identified in strains DBA/2J and FVB/N. Belongs to the MS4A family. Sequence=BAE43134.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; membrane integral component of membrane uc008gro.1 uc008gro.2 uc008gro.3 
ENSMUST00000025639.7 Ccdc86 ENSMUST00000025639.7 coiled-coil domain containing 86 (from RefSeq NM_023731.3) CCD86_MOUSE Cyclon D19Ertd678e ENSMUST00000025639.1 ENSMUST00000025639.2 ENSMUST00000025639.3 ENSMUST00000025639.4 ENSMUST00000025639.5 ENSMUST00000025639.6 MNCb-4327 NM_023731 Q8BGH9 Q8C2F2 Q9JJ89 uc008grj.1 uc008grj.2 uc008grj.3 Nucleus Highly expressed in testis. Also expressed in heart, liver, kidney. By interleukin-3 (IL3). Citrullinated by PADI4. nucleus nucleolus uc008grj.1 uc008grj.2 uc008grj.3 
ENSMUST00000025641.2 Zp1 ENSMUST00000025641.2 zona pellucida glycoprotein 1 (from RefSeq NM_009580.2) ENSMUST00000025641.1 NM_009580 Q62005 Q62016 ZP1_MOUSE uc008grh.1 uc008grh.2 uc008grh.3 uc008grh.4 Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida. Polymers of ZP2 and ZP3 organized into long filaments cross- linked by ZP1 homodimers. Interacts with ZP3. [Processed zona pellucida sperm-binding protein 1]: Zona pellucida Cell membrane ; Single-pass type I membrane protein Expressed in oocytes. Not detected in resting oocytes. As oocytes begin to grow, levels increase to reach a maximum in midsized oocytes. Levels decrease in later stages of oocyte growth. The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida. Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. O-glycosylated. Belongs to the ZP domain family. ZPB subfamily. extracellular region plasma membrane single fertilization membrane integral component of membrane egg coat uc008grh.1 uc008grh.2 uc008grh.3 uc008grh.4 
ENSMUST00000025642.14 Prpf19 ENSMUST00000025642.14 pre-mRNA processing factor 19, transcript variant 2 (from RefSeq NM_134129.4) ENSMUST00000025642.1 ENSMUST00000025642.10 ENSMUST00000025642.11 ENSMUST00000025642.12 ENSMUST00000025642.13 ENSMUST00000025642.2 ENSMUST00000025642.3 ENSMUST00000025642.4 ENSMUST00000025642.5 ENSMUST00000025642.6 ENSMUST00000025642.7 ENSMUST00000025642.8 ENSMUST00000025642.9 NM_134129 PRP19_MOUSE Prp19 Prpf19 Q3TP64 Q4ADG5 Q8BKZ5 Q8BVQ4 Q99KP6 Snev uc008grf.1 uc008grf.2 uc008grf.3 uc008grf.4 [Isoform 1]: Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries. The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair. Beside its role in pre- mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response. May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA. As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process. In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:17349974). May play a role in the biogenesis of lipid droplets (PubMed:17118936). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity). [Isoform 2]: Forced expression leads to suppression of neuronal differentiation, and on the contrary to stimulation of astroglial cell differentiation in retinoic acid-primed P19 cells (PubMed:16352598). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homotetramer. Component of activated, catalytic and post- catalytic spliceosomes. Component of the Prp19 complex/PRP19C/Nineteen complex/NTC and related complexes described as PRP19-CDC5L splicing complex and PSO4 complex. A homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2 constitute the core of those complexes. The interaction with CDC5L, PLRG1 and BCAS2 is direct within this core complex. At least three less stably associated proteins CTNNBL1, CWC15 and HSPA8 are found in the Prp19 complex. The Prp19 complex associates with the spliceosome during its assembly and remodeling recruiting additional proteins. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Interacts with CWC22 and EIF4A3 in an RNA-independent manner. Interacts with RPA1 and RPA2; the PRP19-CDC5L complex is recruited to the sites of DNA repair where it interacts with the replication protein A complex (RPA). Interacts with SETMAR; required for SETMAR recruitment to site of DNA damage. Interacts with U2AF2; the interaction is direct and recruits the Prp19 complex to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA. Interacts with PRPF3. Interacts with APEX1, DNTT and PSMB4. Interacts with KNSTRN (By similarity). Interacts with PSMC5 (PubMed:17349974). Isoform 2 (via N-terminus) interacts with PPIA. Isoform 2 does not interact with CDC5L (PubMed:16352598). Interacts with KHDC4 (By similarity). Interacts with USB1 (By similarity). [Isoform 1]: Nucleus Nucleus, nucleoplasm Cytoplasm, cytoskeleton, spindle Cytoplasm Lipid droplet Note=Nucleoplasmic in interphase cells. Irregularly distributed in anaphase cells. In prophase cells, uniformly distributed, but not associated with condensing chromosomes. Found in extrachromosomal regions in metaphase cells. Mainly localized to the mitotic spindle apparatus when chromosomes segregate during anaphase. When nuclei reform during late telophase, uniformly distributed in daughter cells and displays no preferred association with decondensing chromatin. Recruited on damaged DNA at sites of double-strand break (By similarity). [Isoform 2]: Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99KP6-1; Sequence=Displayed; Name=2; IsoId=Q99KP6-2; Sequence=VSP_011945; Name=3; IsoId=Q99KP6-3; Sequence=VSP_012192; Expressed in white and brown adipose tissues, brain and to a lower extent in liver, kidney, muscle, lung and spleen (at protein level). Up-regulated in differentiating adipocytes (PubMed:17118936). Isoform 2 maximal expression level during the neural differentiation of P19 cells treated with retinoic acid (RA) is estimated to be 2.5-fold of the expression level of the untreated cells and it is detected 1-2 days after RA treatment and it decreases steeply thereafter to the basal level. Isoform 2 expression level increases steeply after 1 day of RA treatment and is estimated to be 4.2-fold of the original level at 0 hours (PubMed:16352598). The 7 WD repeats are necessary and sufficient to support interaction with the RPA complex. Belongs to the WD repeat PRP19 family. protein polyubiquitination spliceosomal tri-snRNP complex assembly spliceosomal complex assembly generation of catalytic spliceosome for first transesterification step mRNA splicing, via spliceosome Prp19 complex inner cell mass cell proliferation ubiquitin-protein transferase activity protein binding nucleus nucleoplasm DNA replication factor A complex spliceosomal complex cytoplasm lipid particle spindle cytoskeleton DNA repair double-strand break repair via nonhomologous end joining mRNA processing cellular response to DNA damage stimulus RNA splicing lipid biosynthetic process proteasomal protein catabolic process protein ubiquitination nuclear speck transferase activity ubiquitin-ubiquitin ligase activity cellular protein localization site of double-strand break identical protein binding negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of mRNA splicing, via spliceosome positive regulation of astrocyte differentiation ubiquitin protein ligase activity protein K63-linked ubiquitination U2-type catalytic step 1 spliceosome U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome signal transduction involved in DNA damage checkpoint uc008grf.1 uc008grf.2 uc008grf.3 uc008grf.4 
ENSMUST00000025645.14 Tmem132a ENSMUST00000025645.14 transmembrane protein 132A, transcript variant 1 (from RefSeq NM_133804.2) ENSMUST00000025645.1 ENSMUST00000025645.10 ENSMUST00000025645.11 ENSMUST00000025645.12 ENSMUST00000025645.13 ENSMUST00000025645.2 ENSMUST00000025645.3 ENSMUST00000025645.4 ENSMUST00000025645.5 ENSMUST00000025645.6 ENSMUST00000025645.7 ENSMUST00000025645.8 ENSMUST00000025645.9 Kiaa1583 NM_133804 Q69ZF9 Q8BX93 Q922P8 T132A_MOUSE uc008grc.1 uc008grc.2 uc008grc.3 May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity). Interacts with HSPA5/GRP78. Golgi apparatus membrane ; Single- pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Belongs to the TMEM132 family. Sequence=BAC33373.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAD32485.1; Type=Erroneous initiation; Evidence=; Golgi membrane molecular_function endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus membrane integral component of membrane negative regulation of programmed cell death uc008grc.1 uc008grc.2 uc008grc.3 
ENSMUST00000025646.3 Slc15a3 ENSMUST00000025646.3 solute carrier family 15, member 3 (from RefSeq NM_023044.2) Ci1 ENSMUST00000025646.1 ENSMUST00000025646.2 NM_023044 Pht2 Q8BPX9 Q9WU80 S15A3_MOUSE Slc15a3 uc008gra.1 uc008gra.2 uc008gra.3 Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (PubMed:24695226). Also able to transport carnosine (By similarity). Involved in the detection of microbial pathogens by toll- like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:24695226). Reaction=n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in); Xref=Rhea:RHEA:76371, ChEBI:CHEBI:15378, ChEBI:CHEBI:155830; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76372; Evidence=; Reaction=glycylglycylglycine(out) + n H(+)(out) = glycylglycylglycine(in) + n H(+)(in); Xref=Rhea:RHEA:76391, ChEBI:CHEBI:15378, ChEBI:CHEBI:195214; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76392; Evidence=; Reaction=carnosine(out) + n H(+)(out) = carnosine(in) + n H(+)(in); Xref=Rhea:RHEA:76383, ChEBI:CHEBI:15378, ChEBI:CHEBI:57485; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76384; Evidence=; Reaction=n H(+)(out) + L-histidine(out) = n H(+)(in) + L-histidine(in); Xref=Rhea:RHEA:76379, ChEBI:CHEBI:15378, ChEBI:CHEBI:57595; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76380; Evidence=; Lysosome membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Expressed highly in bone marrow derived macrophages, and weakly in spleen and lung (PubMed:11004510). Expressed in plasmacytoid dendritic cells (pDCs) in response to toll-like receptors (TLR) stimulation (PubMed:24695226). Belongs to the major facilitator superfamily. Proton- dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. lysosome lysosomal membrane oligopeptide transport protein transport symporter activity peptide:proton symporter activity peptide transport membrane integral component of membrane transmembrane transporter activity oligopeptide transmembrane transport oligopeptide transmembrane transporter activity intracellular membrane-bounded organelle transmembrane transport hydrogen ion transmembrane transport peptide transmembrane transporter activity uc008gra.1 uc008gra.2 uc008gra.3 
ENSMUST00000025647.7 Pga5 ENSMUST00000025647.7 pepsinogen 5, group I (from RefSeq NM_021453.4) ENSMUST00000025647.1 ENSMUST00000025647.2 ENSMUST00000025647.3 ENSMUST00000025647.4 ENSMUST00000025647.5 ENSMUST00000025647.6 NM_021453 PEPA5_MOUSE Pepf Pga5 Q9D106 Q9JKE6 uc008gqp.1 uc008gqp.2 uc008gqp.3 uc008gqp.4 Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Reaction=Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His- 5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu- 17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.; EC=3.4.23.1; Evidence=; Inhibited by pepstatin A. Secreted Expressed in glandular chief cells of the neonatal stomach. Expressed in yolk sacs of the placenta (at protein level). In neonatal stomach, highly expressed for the first two weeks after birth, with rapidly decreasing expression after 17.5 days. In placenta, detected from 11.5 dpc until term. Belongs to the peptidase A1 family. aspartic-type endopeptidase activity cellular_component extracellular region proteolysis peptidase activity hydrolase activity protein metabolic process protein catabolic process uc008gqp.1 uc008gqp.2 uc008gqp.3 uc008gqp.4 
ENSMUST00000025649.10 Ddb1 ENSMUST00000025649.10 damage specific DNA binding protein 1, transcript variant 2 (from RefSeq NM_015735.3) DDB1_MOUSE ENSMUST00000025649.1 ENSMUST00000025649.2 ENSMUST00000025649.3 ENSMUST00000025649.4 ENSMUST00000025649.5 ENSMUST00000025649.6 ENSMUST00000025649.7 ENSMUST00000025649.8 ENSMUST00000025649.9 NM_015735 Q3U1J4 Q3U4D0 Q3U8G3 Q3UJC4 Q99LV3 Q9QYK0 Q9WV39 uc008gqm.1 uc008gqm.2 uc008gqm.3 uc008gqm.4 uc008gqm.5 Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:12107171, PubMed:26431207, PubMed:28790135). Core component of the UV-DDB complex (UV-damaged DNA- binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:12107171). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6- 4 photoproducts (6-4 PP), apurinic sites and short mismatches (By similarity). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (By similarity). DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB- RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (By similarity). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (By similarity). DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (By similarity). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication (By similarity). DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) (By similarity). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). DDB1- mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1- mediated gluconeogenesis in the liver (PubMed:28790135). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (PubMed:24357321). Maternal factor required for proper zygotic genome activation and genome reprogramming (PubMed:24357321). Protein modification; protein ubiquitination. Component of the UV-DDB complex which includes DDB1 and DDB2; the heterodimer dimerizes to give rise to a heterotetramer when bound to damaged DNA. The UV-DDB complex interacts with monoubiquitinated histone H2A and binds to XPC via the DDB2 subunit. Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which consist of a core of DDB1, CUL4A or CUL4B and RBX1. DDB1 may recruit specific substrate targeting subunits to the DCX complex. These substrate targeting subunits are generally known as DCAF (DDB1- and CUL4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Interacts with AMBRA1, ATG16L1, BTRC, CRBN, DCAF1, DCAF4, DCAF5, DCAF6, DCAF7, DCAF8, DCAF9, DCAF10, DCAF11, DCAF12, DCAF15, DCAF16, DCAF17, DDA1, DET1, DTL, ERCC8, FBXW5, FBXW8, GRWD1, KATNB1, NLE1, NUP43, PAFAH1B1, PHIP, PWP1, RBBP4, RBBP5, RBBP7, COP1, SNRNP40, DCAF1, WDR5, WDR5B, WDR12, WDR26, WDR39, WDR42, WDR53, WDR59, WDR61, WSB1, WSB2, LRWD1 and WDTC1. DCX complexes may associate with the COP9 signalosome, and this inhibits the E3 ubiquitin-protein ligase activity of the complex. Interacts with NF2, TSC1 and TSC2. Interacts with AGO1 and AGO2. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts directly with DYRK2. DCX(DTL) complex interacts with FBXO11; does not ubiquitinate and degradate FBXO11. Interacts with TRPC4AP (By similarity). Interacts with CRY1 and CRY2 (PubMed:27123980). The DDB1- CUL4A complex interacts with CRY1 (PubMed:27123980). Component of the DCX(DCAF13) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1, DCAF13 and RBX1. Interacts with DCAF13 (via WD40 domain) (PubMed:30111536, PubMed:31492966, PubMed:35178836). Q3U1J4; O08785: Clock; NbExp=4; IntAct=EBI-2552275, EBI-79859; Q3U1J4; Q923J1: Trpm7; NbExp=2; IntAct=EBI-2552275, EBI-8010314; Cytoplasm Nucleus Note=Primarily cytoplasmic. Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage (By similarity). More concentrated in nuclei than in cytoplasm in germinal vesicle (GV) stage oocytes, zygotes and the 2- cell stage, but distributed in the cytoplasm at the MII-stage oocytes (PubMed:24357321). Widely expressed. Expressed in pregnant, lactating and involuting mammary gland. Expressed in oocytes (at protein level) (PubMed:24357321). Expressed in germinal vesicle (GV) stage and MII- stage oocytes and zygotes. Expression then decreases from 2-cell stage to blastula (PubMed:24357321). Widely expressed at 8.5 dpc, 9.5 dpc, 12.5 dpc, and 19.5 dpc (PubMed:10574459). The core of the protein consists of three WD40 beta-propeller domains. Phosphorylated by ABL1. Ubiquitinated by CUL4A. Subsequently degraded by ubiquitin- dependent proteolysis. Acetylated, promoting interaction with CUL4 (CUL4A or CUL4B) and subsequent formation of DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Deacetylation by SIRT7 impairs the interaction with CUL4 (CUL4A or CUL4B) and formation of DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Mice showed impaired gluconeogenesis in the liver. Belongs to the DDB1 family. nucleic acid binding DNA binding damaged DNA binding protein binding nucleus nucleoplasm cytoplasm DNA repair ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus proteasomal protein catabolic process Wnt signaling pathway protein ubiquitination protein binding, bridging Cul4A-RING E3 ubiquitin ligase complex Cul4B-RING E3 ubiquitin ligase complex macromolecular complex histone H2A monoubiquitination regulation of circadian rhythm negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecular complex binding positive regulation of viral genome replication positive regulation of gluconeogenesis positive regulation of protein catabolic process positive regulation by virus of viral protein levels in host cell rhythmic process interaction with symbiont UV-damage excision repair WD40-repeat domain binding Cul4-RING E3 ubiquitin ligase complex cullin family protein binding regulation of mitotic cell cycle phase transition positive regulation of viral release from host cell uc008gqm.1 uc008gqm.2 uc008gqm.3 uc008gqm.4 uc008gqm.5 
ENSMUST00000025656.4 Aldh1a7 ENSMUST00000025656.4 aldehyde dehydrogenase family 1, subfamily A7 (from RefSeq NM_011921.3) AL1A7_MOUSE Aldh-pb Aldh1a7 ENSMUST00000025656.1 ENSMUST00000025656.2 ENSMUST00000025656.3 NM_011921 O35945 Q80ZX7 uc008gyn.1 uc008gyn.2 uc008gyn.3 Can oxidize benzaldehyde, propionaldehyde and acetaldehyde (By similarity). No detectable activity with retinal. Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. Homotetramer. Cytoplasm Highest level in liver, high level in lung, low level in kidney and testis. Xenopus embryos injected with Aldh1a7 mRNA failed to produce retinoic acid in contrast to embryos injected with Aldh1a1. Belongs to the aldehyde dehydrogenase family. aldehyde dehydrogenase (NAD) activity cytoplasm ethanol catabolic process oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor benzaldehyde dehydrogenase (NAD+) activity glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity oxidation-reduction process retinoic acid metabolic process uc008gyn.1 uc008gyn.2 uc008gyn.3 
ENSMUST00000025663.8 Cemip2 ENSMUST00000025663.8 cell migration inducing hyaluronidase 2, transcript variant 2 (from RefSeq NM_001033759.2) CEIP2_MOUSE Cemip2 ENSMUST00000025663.1 ENSMUST00000025663.2 ENSMUST00000025663.3 ENSMUST00000025663.4 ENSMUST00000025663.5 ENSMUST00000025663.6 ENSMUST00000025663.7 Kiaa1412 NM_001033759 Q3UE15 Q3UE98 Q5FWI3 Q6DFZ0 Q6ZPR7 Q8VE53 Q9QY22 Tmem2 uc008gzh.1 uc008gzh.2 uc008gzh.3 uc008gzh.4 uc008gzh.5 Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate- size hyaluronan of approximately 5 kDa fragments (PubMed:28246172, PubMed:37196767). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172). Has an essential function in systemic hyaluronan catabolism and turnover and regulates cell adhesion and migration via hyaluronan degradation at focal adhesion sites (PubMed:34624311, PubMed:33647313). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D- glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35; Evidence= Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; pH dependence: Optimum pH is 6-7. ; Cell membrane ; Single-pass type II membrane protein Widely expressed (PubMed:10767548, PubMed:28246172). Strongly expressed in endothelial cells in the subcapsular sinus of lymph nodes and in the liver sinusoid, two primary sites implicated in systemic hyaluronan turnover (PubMed:34624311). Expressed ubiquitously at early stages of development. Expressed in the endocardial cells lining the ventricles and atria at 9.5 dpc. Belongs to the CEMIP family. Sequence=AAH19745.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; angiogenesis hyalurononglucosaminidase activity calcium ion binding plasma membrane integral component of plasma membrane multicellular organism development metabolic process membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds hyaluronan catabolic process regulation of sprouting angiogenesis uc008gzh.1 uc008gzh.2 uc008gzh.3 uc008gzh.4 uc008gzh.5 
ENSMUST00000025666.8 Slc22a19 ENSMUST00000025666.8 solute carrier family 22 (organic anion transporter), member 19 (from RefSeq NM_144785.2) ENSMUST00000025666.1 ENSMUST00000025666.2 ENSMUST00000025666.3 ENSMUST00000025666.4 ENSMUST00000025666.5 ENSMUST00000025666.6 ENSMUST00000025666.7 NM_144785 Oat5 Q6A4K9 Q8VCA0 S22AJ_MOUSE Slc22a19 Slc22a9 uc008glo.1 uc008glo.2 uc008glo.3 uc008glo.4 uc008glo.5 Sodium-independent organic anion transporter which shows high specificity for estrone sulfate, dehydroepiandrosterone sulfate, and the mycotoxin ochratoxin A (OTA) (PubMed:15068970, PubMed:16150593). Transport of OTA is strongly inhibited by estrone sulfate and probenecid, and to a lesser extent by 2,4-dichlorophenoxyacetic acid (2,4-D) and salicylate (PubMed:15068970). Transport of estrone sulfate is inhibited by various steroid sulfate conjugates including dehydroepiandrosterone sulfate, alpha-naphthyl sulfate, beta-estradiol sulfate, 4-methylumbelliferyl sulfate and p-nitrophenyl sulfate (but not minoxidil sulfate) (PubMed:16150593). Kinetic parameters: KM=2.0 uM for ochratoxin A ; KM=2.2 uM for estrone sulfate ; KM=3.8 uM for dehydroepiandrosterone sulfate ; Apical cell membrane ; Multi-pass membrane protein Specifically expressed in kidney, where it localizes to proximal tubules of the outer medulla (at protein level) (PubMed:15068970, PubMed:16150593). Not detected in other tissues tested (PubMed:15068970). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. response to molecule of fungal origin plasma membrane ion transport organic anion transmembrane transporter activity organic anion transport membrane integral component of membrane apical plasma membrane toxin transporter activity transmembrane transporter activity transmembrane transport toxin transport uc008glo.1 uc008glo.2 uc008glo.3 uc008glo.4 uc008glo.5 
ENSMUST00000025668.9 Atl3 ENSMUST00000025668.9 atlastin GTPase 3, transcript variant 2 (from RefSeq NM_146091.4) ATLA3_MOUSE ENSMUST00000025668.1 ENSMUST00000025668.2 ENSMUST00000025668.3 ENSMUST00000025668.4 ENSMUST00000025668.5 ENSMUST00000025668.6 ENSMUST00000025668.7 ENSMUST00000025668.8 NM_146091 Q3UGW3 Q8C0L7 Q8C174 Q91YH5 Q99LZ9 uc008glg.1 uc008glg.2 uc008glg.3 uc008glg.4 uc008glg.5 GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity). Interacts with ZFYVE27 (By similarity). Interacts with REEP5 (PubMed:32075961). Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Localizes to endoplasmic reticulum tubules and accumulates in punctuate structures corresponding to 3-way junctions, which represent crossing-points at which the tubules build a polygonal network. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91YH5-1; Sequence=Displayed; Name=2; IsoId=Q91YH5-2; Sequence=VSP_025314; Expressed in cardiomyocytes (at protein level). Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily. Sequence=AAH02149.1; Type=Erroneous initiation; Evidence=; nucleotide binding GTPase activity GTP binding endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum organization Golgi organization membrane integral component of membrane hydrolase activity identical protein binding protein homooligomerization endoplasmic reticulum tubular network endoplasmic reticulum tubular network membrane positive regulation of endoplasmic reticulum tubular network organization uc008glg.1 uc008glg.2 uc008glg.3 uc008glg.4 uc008glg.5 
ENSMUST00000025675.11 Naa40 ENSMUST00000025675.11 N(alpha)-acetyltransferase 40, NatD catalytic subunit (from RefSeq NM_027643.1) ENSMUST00000025675.1 ENSMUST00000025675.10 ENSMUST00000025675.2 ENSMUST00000025675.3 ENSMUST00000025675.4 ENSMUST00000025675.5 ENSMUST00000025675.6 ENSMUST00000025675.7 ENSMUST00000025675.8 ENSMUST00000025675.9 NAA40_MOUSE NM_027643 Naa40 Nat11 Patt1 Q3V3R7 Q6PE89 Q8VE10 Q9D4I5 uc008gkl.1 uc008gkl.2 uc008gkl.3 uc008gkl.4 N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (By similarity). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (By similarity). Acts as a negative regulator of apoptosis (By similarity). May play a role in hepatic lipid metabolism (PubMed:22231784). Reaction=acetyl-CoA + N-terminal L-seryl-[histone H4] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-seryl-[histone H4]; Xref=Rhea:RHEA:50596, Rhea:RHEA-COMP:12740, Rhea:RHEA-COMP:12743, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64738, ChEBI:CHEBI:83690; EC=2.3.1.257; Evidence=; Reaction=acetyl-CoA + N-terminal L-seryl-[histone H2A] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]; Xref=Rhea:RHEA:50600, Rhea:RHEA-COMP:12742, Rhea:RHEA-COMP:12744, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64738, ChEBI:CHEBI:83690; EC=2.3.1.257; Evidence=; Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VE10-1; Sequence=Displayed; Name=2; IsoId=Q8VE10-2; Sequence=VSP_024745; Name=3; IsoId=Q8VE10-3; Sequence=VSP_024744, VSP_024746; Liver-specific knockout male mice have decreased body mass and are protected from age-associated hepatic steatosis. Male mice show a reduction in the liver triglyceride and free fatty acid levels. No effect on liver cholesterol level, liver weight, and liver function is observed. Belongs to the acetyltransferase family. NAA40 subfamily. Sequence=BAB30275.1; Type=Frameshift; Evidence=; cellular_component nucleus cytoplasm N-terminal protein amino acid acetylation lipid metabolic process N-acetyltransferase activity H4 histone acetyltransferase activity transferase activity transferase activity, transferring acyl groups histone H4 acetylation histone H2A acetylation H2A histone acetyltransferase activity regulation of chromatin silencing at rDNA peptide-serine-N-acetyltransferase activity uc008gkl.1 uc008gkl.2 uc008gkl.3 uc008gkl.4 
ENSMUST00000025679.11 Otub1 ENSMUST00000025679.11 OTU domain, ubiquitin aldehyde binding 1 (from RefSeq NM_134150.2) ENSMUST00000025679.1 ENSMUST00000025679.10 ENSMUST00000025679.2 ENSMUST00000025679.3 ENSMUST00000025679.4 ENSMUST00000025679.5 ENSMUST00000025679.6 ENSMUST00000025679.7 ENSMUST00000025679.8 ENSMUST00000025679.9 NM_134150 OTUB1_MOUSE Q3ULV9 Q3V408 Q7TQI3 Q8C326 Q8R5F2 uc008gki.1 uc008gki.2 uc008gki.3 Hydrolase that can specifically remove compared to 'Lys-48'- linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation (By similarity). Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen (PubMed:14661020). Acts via its interaction with RNF128/GRAIL (PubMed:14661020). Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128 (PubMed:14661020). Deubiquitinates estrogen receptor alpha (ESR1) (By similarity). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains (By similarity). Not able to cleave di-ubiquitin (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (By similarity). Plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites. Inhibits RNF168 independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N/UBC13, the E2 partner of RNF168, thereby limiting spreading of 'Lys-63'-linked histone H2A and H2AX marks. Inhibition occurs by binding to free ubiquitin: free ubiquitin acts as an allosteric regulator that increases affinity for UBE2N/UBC13 and disrupts interaction with UBE2V1. The OTUB1- UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved 'Lys48'-linked di-ubiquitin chain. Acts as a regulator of mTORC1 and mTORC2 complexes. When phosphorylated at Tyr-26, acts as an activator of the mTORC1 complex by mediating deubiquitination of RPTOR via a non-catalytic process: acts by binding and inhibiting the activity of the ubiquitin-conjugating enzyme E2 (UBE2D1/UBCH5A, UBE2W/UBC16 and UBE2N/UBC13), thereby preventing ubiquitination of RPTOR. Can also act as an inhibitor of the mTORC1 and mTORC2 complexes in response to amino acids by mediating non-catalytic deubiquitination of DEPTOR. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; By free ubiquitin: binding of free ubiquitin triggers conformational changes in the OTU domain and formation of a ubiquitin-binding helix in the N-terminus, promoting binding of the conjugated donor ubiquitin in UBE2N/UBC13 to OTUB1. Interacts with RNF128. Forms a ternary complex with RNF128 and USP8. Interacts with FUS and RACK1. Interacts with UBE2D1/UBCH5A, UBE2W/UBC16 and UBE2N/UBC13. Cytoplasm Phosphorylation at Tyr-26 by SRC and SRMS promotes deubiquitination of RPTOR via a non-catalytic process. Belongs to the peptidase C65 family. adaptive immune response immune system process thiol-dependent ubiquitin-specific protease activity nucleus cytoplasm DNA repair proteolysis cellular response to DNA damage stimulus peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity NEDD8-specific protease activity ubiquitin protein ligase binding thiol-dependent ubiquitinyl hydrolase activity ubiquitin binding protein K48-linked deubiquitination cellular response to interleukin-1 ubiquitinyl hydrolase activity negative regulation of histone H2A K63-linked ubiquitination negative regulation of double-strand break repair uc008gki.1 uc008gki.2 uc008gki.3 
ENSMUST00000025680.5 Lipf ENSMUST00000025680.5 lipase, gastric (from RefSeq NM_026334.3) ENSMUST00000025680.1 ENSMUST00000025680.2 ENSMUST00000025680.3 ENSMUST00000025680.4 LIPF_MOUSE NM_026334 Q8BK78 Q9CPP7 Q9CPP8 Q9D6L1 Q9D6L9 Q9D6M9 Q9D6N8 Q9D6P3 Q9D6Q2 Q9D6Q3 Q9D6Q6 Q9D6S5 Q9D6T5 Q9D6X0 Q9D760 Q9D766 Q9D767 Q9D796 Q9D798 Q9D7C5 uc008hfw.1 uc008hfw.2 uc008hfw.3 Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (By similarity). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (By similarity). Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+); Xref=Rhea:RHEA:39931, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52333, ChEBI:CHEBI:53753; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39932; Evidence=; Reaction=1,2,3-trioctanoylglycerol + H2O = 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate; Xref=Rhea:RHEA:40047, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:76978, ChEBI:CHEBI:76979; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40048; Evidence=; Secreted Belongs to the AB hydrolase superfamily. Lipase family. triglyceride lipase activity cellular_component extracellular region mitochondrion malate metabolic process lipid metabolic process lipid catabolic process malate dehydrogenase activity hydrolase activity hydrolase activity, acting on ester bonds intracellular membrane-bounded organelle oxidation-reduction process uc008hfw.1 uc008hfw.2 uc008hfw.3 
ENSMUST00000025681.8 Cdc42bpg ENSMUST00000025681.8 CDC42 binding protein kinase gamma (from RefSeq NM_001033342.1) Cdc42bpg ENSMUST00000025681.1 ENSMUST00000025681.2 ENSMUST00000025681.3 ENSMUST00000025681.4 ENSMUST00000025681.5 ENSMUST00000025681.6 ENSMUST00000025681.7 MRCKG_MOUSE NM_001033342 Q80UW5 uc008gia.1 uc008gia.2 uc008gia.3 uc008gia.4 May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation (By similarity). Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42 (By similarity). Cytoplasm Note=Concentrates at the leading edge of cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm microtubule organizing center cytosol cytoskeleton protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-threonine phosphorylation actomyosin structure organization cell leading edge actin cytoskeleton reorganization intracellular signal transduction metal ion binding uc008gia.1 uc008gia.2 uc008gia.3 uc008gia.4 
ENSMUST00000025682.12 Lipn ENSMUST00000025682.12 lipase, family member N (from RefSeq NM_027340.2) ENSMUST00000025682.1 ENSMUST00000025682.10 ENSMUST00000025682.11 ENSMUST00000025682.2 ENSMUST00000025682.3 ENSMUST00000025682.4 ENSMUST00000025682.5 ENSMUST00000025682.6 ENSMUST00000025682.7 ENSMUST00000025682.8 ENSMUST00000025682.9 LIPN_MOUSE Lipl4 NM_027340 Q3U4B4 uc008hfz.1 uc008hfz.2 Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity). Secreted Belongs to the AB hydrolase superfamily. Lipase family. extracellular region lipid metabolic process lipid catabolic process hydrolase activity hydrolase activity, acting on ester bonds intracellular membrane-bounded organelle uc008hfz.1 uc008hfz.2 
ENSMUST00000025684.4 Ehd1 ENSMUST00000025684.4 EH-domain containing 1 (from RefSeq NM_010119.5) EHD1_MOUSE ENSMUST00000025684.1 ENSMUST00000025684.2 ENSMUST00000025684.3 Ehd1 NM_010119 Past1 Q9WVK4 uc008ghz.1 uc008ghz.2 uc008ghz.3 ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (By similarity). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15930129, PubMed:20159556). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (PubMed:21177873). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (PubMed:24373286). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (By similarity). Homooligomer, and heterooligomer with EHD2, EHD3 and EHD4, ATP-binding is required for heterooligomerization (By similarity). Interacts (via EH domain) with MICALL1 (via NPF1 motif); the interaction is direct and recruits EHD1 to membranes (PubMed:23572513). Interacts with RAB35; the interaction is indirect through MICALL1 and recruits EHD1 to membranes (PubMed:23572513). Interacts (via EH domain) with PACSIN2 (via NPF motifs); regulates localization to tubular recycling endosome membranes (PubMed:15930129). Interacts with PACSIN1 (PubMed:15930129). Interacts with RAB8A (By similarity). Interacts with FER1L5 (via second C2 domain) (PubMed:21177873). Interacts with MYOF (PubMed:21177873). Interacts with ZFYVE20 (By similarity). Interacts (via EH domain) with RAB11FIP2 (By similarity). Recycling endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle Cell projection, cilium membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Preferentially associates with tubular recycling endosomes (By similarity). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (PubMed:21177873). Localizes to the ciliary pocket from where the cilium protrudes (By similarity). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals. Highly expressed in testis. Also expressed in kidney, heart, intestine, and brain. Expression is already noted at day 9.5 in the limb buds and pharyngeal arches and at day 10.5 in sclerotomes, at various elements of the branchial apparatus (mandible and hyoid), and in the occipital region. At day 15.5 expression peaks in cartilage, preceding hypertrophy and ossification, and at day 17.5 there is no expression in the bones. The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily. nucleotide binding calcium ion binding protein binding ATP binding GTP binding endosome early endosome lipid particle plasma membrane cilium intracellular protein transport endocytosis endosome membrane positive regulation of cholesterol storage positive regulation of neuron projection development protein transport membrane endosomal transport Rab GTPase binding ciliary pocket membrane cell projection organization endocytic vesicle platelet dense tubular network membrane neuron projection development cytoplasmic vesicle early endosome membrane endocytic recycling low-density lipoprotein particle clearance cholesterol homeostasis identical protein binding cell projection myelin sheath metal ion binding perinuclear region of cytoplasm protein homooligomerization recycling endosome membrane ciliary membrane cilium assembly protein localization to cilium positive regulation of myoblast fusion cellular response to nerve growth factor stimulus positive regulation of endocytic recycling uc008ghz.1 uc008ghz.2 uc008ghz.3 
ENSMUST00000025685.8 Lipm ENSMUST00000025685.8 lipase, family member M (from RefSeq NM_023903.1) ENSMUST00000025685.1 ENSMUST00000025685.2 ENSMUST00000025685.3 ENSMUST00000025685.4 ENSMUST00000025685.5 ENSMUST00000025685.6 ENSMUST00000025685.7 LIPM_MOUSE Lipl3 NM_023903 Q8BJ28 Q8K2A6 uc008hga.1 uc008hga.2 uc008hga.3 uc008hga.4 Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity). Secreted Belongs to the AB hydrolase superfamily. Lipase family. cellular_component extracellular region lipid metabolic process lipid catabolic process hydrolase activity hydrolase activity, acting on ester bonds uc008hga.1 uc008hga.2 uc008hga.3 uc008hga.4 
ENSMUST00000025686.9 Ankrd22 ENSMUST00000025686.9 ankyrin repeat domain 22 (from RefSeq NM_024204.6) ANR22_MOUSE ENSMUST00000025686.1 ENSMUST00000025686.2 ENSMUST00000025686.3 ENSMUST00000025686.4 ENSMUST00000025686.5 ENSMUST00000025686.6 ENSMUST00000025686.7 ENSMUST00000025686.8 NM_024204 Q9CZ89 Q9D3I2 Q9D3J5 uc008hgb.1 uc008hgb.2 uc008hgb.3 uc008hgb.4 molecular_function cellular_component biological_process uc008hgb.1 uc008hgb.2 uc008hgb.3 uc008hgb.4 
ENSMUST00000025691.13 Fas ENSMUST00000025691.13 Fas cell surface death receptor, transcript variant 1 (from RefSeq NM_007987.2) Apt1 ENSMUST00000025691.1 ENSMUST00000025691.10 ENSMUST00000025691.11 ENSMUST00000025691.12 ENSMUST00000025691.2 ENSMUST00000025691.3 ENSMUST00000025691.4 ENSMUST00000025691.5 ENSMUST00000025691.6 ENSMUST00000025691.7 ENSMUST00000025691.8 ENSMUST00000025691.9 NM_007987 P25446 Q6GT31 Q9DCQ1 TNR6_MOUSE Tnfrsf6 uc008hgi.1 uc008hgi.2 uc008hgi.3 uc008hgi.4 Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). Binds DAXX (PubMed:9215629). Interacts with HIPK3 (PubMed:11034606). Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BABAM2 and FEM1B. Interacts with FADD (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (PubMed:15383280). Interacts with CALM (By similarity). In the absence of stimulation, interacts with BIRC2, DDX3X and GSK3B. The interaction with BIRC2 and DDX3X is further enhanced upon receptor stimulation and accompanied by DDX3X and BIRC2 cleavage (By similarity). P25446; O89110: Casp8; NbExp=3; IntAct=EBI-296206, EBI-851690; P25446; O35613: Daxx; NbExp=2; IntAct=EBI-296206, EBI-77304; P25446; Q61160: Fadd; NbExp=3; IntAct=EBI-296206, EBI-524415; P25446; Q9ERH7: Hipk3; NbExp=3; IntAct=EBI-296206, EBI-524356; P25446; Q60953: Pml; NbExp=6; IntAct=EBI-296206, EBI-3895605; P25446; Q9UER7: DAXX; Xeno; NbExp=4; IntAct=EBI-296206, EBI-77321; P25446; Q13158: FADD; Xeno; NbExp=8; IntAct=EBI-296206, EBI-494804; Cell membrane ; Single-pass type I membrane protein Membrane raft Detected in various tissues including thymus, liver, lung, heart, and adult ovary. Expression oscillates in a circadian manner in the liver with peak levels seen at CT12. Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins. Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane. Note=Defects in Fas are the cause of the lymphoproliferation phenotype (lpr) (PubMed:1372394). Lpr mice show lymphadenopathy and autoantibody production (PubMed:1372394). positive regulation of protein phosphorylation protease binding immunoglobulin production transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity protein binding calmodulin binding extracellular region extracellular space cytoplasm cytosol plasma membrane apoptotic process activation-induced cell death of T cells inflammatory cell apoptotic process immune response signal transduction circadian rhythm extrinsic apoptotic signaling pathway via death domain receptors response to toxic substance external side of plasma membrane cell surface gene expression regulation of gene expression negative regulation of Schwann cell proliferation positive regulation of cell death membrane integral component of membrane apical plasma membrane nuclear body B cell mediated immunity kinase binding secretory granule dendrite regeneration death-inducing signaling complex CD95 death-inducing signaling complex positive regulation of protein complex assembly regulation of stress-activated MAPK cascade tumor necrosis factor-mediated signaling pathway cellular response to amino acid starvation Fas signaling pathway regulation of cell proliferation sarcolemma identical protein binding regulation of apoptotic process neuron projection neuronal cell body T cell homeostasis positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of neuron apoptotic process macromolecular complex binding negative thymic T cell selection membrane raft regulation of lymphocyte differentiation regulation of myeloid cell differentiation perinuclear region of cytoplasm spleen development negative regulation of B cell activation response to glucocorticoid neuron apoptotic process lymphocyte apoptotic process cellular response to lithium ion cellular response to hyperoxia positive regulation of release of cytochrome c from mitochondria motor neuron apoptotic process apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand hepatocyte apoptotic process apical dendrite necroptotic signaling pathway negative regulation of Schwann cell migration positive regulation of apoptotic signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway uc008hgi.1 uc008hgi.2 uc008hgi.3 uc008hgi.4 
ENSMUST00000025694.7 Lipo3 ENSMUST00000025694.7 Belongs to the AB hydrolase superfamily. Lipase family. (from UniProt Q3UT41) AI747699 AK170332 ENSMUST00000025694.1 ENSMUST00000025694.2 ENSMUST00000025694.3 ENSMUST00000025694.4 ENSMUST00000025694.5 ENSMUST00000025694.6 Lipo1 Lipo3 Q3UT41 Q3UT41_MOUSE uc289rrr.1 uc289rrr.2 Belongs to the AB hydrolase superfamily. Lipase family. sterol esterase activity lipid metabolic process lipid catabolic process sterol metabolic process hydrolase activity hydrolase activity, acting on ester bonds intracellular membrane-bounded organelle uc289rrr.1 uc289rrr.2 
ENSMUST00000025695.10 Ppp2r5b ENSMUST00000025695.10 protein phosphatase 2, regulatory subunit B', beta (from RefSeq NM_198168.3) 2A5B_MOUSE ENSMUST00000025695.1 ENSMUST00000025695.2 ENSMUST00000025695.3 ENSMUST00000025695.4 ENSMUST00000025695.5 ENSMUST00000025695.6 ENSMUST00000025695.7 ENSMUST00000025695.8 ENSMUST00000025695.9 NM_198168 Q3V3S8 Q6PD28 Q8R342 uc008ght.1 uc008ght.2 uc008ght.3 As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. Component of the serine/threonine-protein phosphatase 2A complex (PP2A). This complex consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant scaffold subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1. Interacts with AKT1. Cytoplasm Ubiquitinated by CUL3-KLHL15 complex; this modification leads to proteasomal degradation. Belongs to the phosphatase 2A regulatory subunit B56 family. protein phosphatase type 2A complex regulation of protein phosphorylation nucleus cytoplasm cytosol protein dephosphorylation signal transduction regulation of receptor activity positive regulation of neuron projection development protein phosphatase regulator activity positive regulation of protein complex assembly regulation of protein autophosphorylation regulation of phosphoprotein phosphatase activity positive regulation of transcription from RNA polymerase II promoter regulation of peptidyl-tyrosine phosphorylation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of neurotrophin TRK receptor signaling pathway negative regulation of G0 to G1 transition positive regulation of cell cycle arrest cellular response to growth factor stimulus protein phosphatase activator activity uc008ght.1 uc008ght.2 uc008ght.3 
ENSMUST00000025696.5 Ak3 ENSMUST00000025696.5 adenylate kinase 3, transcript variant 1 (from RefSeq NM_021299.2) Ak3l Ak3l1 Akl3l ENSMUST00000025696.1 ENSMUST00000025696.2 ENSMUST00000025696.3 ENSMUST00000025696.4 KAD3_MOUSE NM_021299 Q3UDN7 Q8BGX5 Q9D7Z1 Q9DB57 Q9DBM5 Q9WTP7 uc008hcx.1 uc008hcx.2 uc008hcx.3 Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. Reaction=a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'- diphosphate + ADP; Xref=Rhea:RHEA:13749, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.10; Evidence=; Monomer. Mitochondrion matrix Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis. Belongs to the adenylate kinase family. AK3 subfamily. nucleotide binding adenylate kinase activity ATP binding GTP binding mitochondrion mitochondrial intermembrane space mitochondrial matrix nucleobase-containing compound metabolic process ADP biosynthetic process AMP phosphorylation kinase activity phosphorylation transferase activity phosphotransferase activity, phosphate group as acceptor nucleobase-containing compound kinase activity identical protein binding AMP metabolic process ATP metabolic process GTP metabolic process ITP metabolic process UTP metabolic process dATP metabolic process nucleoside triphosphate adenylate kinase activity protein homooligomerization uc008hcx.1 uc008hcx.2 uc008hcx.3 
ENSMUST00000025698.14 Gpha2 ENSMUST00000025698.14 glycoprotein hormone alpha 2 (from RefSeq NM_130453.3) ENSMUST00000025698.1 ENSMUST00000025698.10 ENSMUST00000025698.11 ENSMUST00000025698.12 ENSMUST00000025698.13 ENSMUST00000025698.2 ENSMUST00000025698.3 ENSMUST00000025698.4 ENSMUST00000025698.5 ENSMUST00000025698.6 ENSMUST00000025698.7 ENSMUST00000025698.8 ENSMUST00000025698.9 GPHA2_MOUSE Gpa2 NM_130453 Q925Q5 Zsig51 uc008ghs.1 uc008ghs.2 uc008ghs.3 Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. Heterodimer with GPHB5; this heterodimer interacts with thyroid-stimulating hormone receptor (TSHR), and hence stimulates cAMP production. Secreted Belongs to the glycoprotein hormones subunit alpha family. hormone activity extracellular region extracellular space cell surface receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway thyrotropin-releasing hormone receptor binding protein heterodimerization activity hormone receptor binding uc008ghs.1 uc008ghs.2 uc008ghs.3 
ENSMUST00000025702.14 Snx15 ENSMUST00000025702.14 sorting nexin 15 (from RefSeq NM_026912.2) ENSMUST00000025702.1 ENSMUST00000025702.10 ENSMUST00000025702.11 ENSMUST00000025702.12 ENSMUST00000025702.13 ENSMUST00000025702.2 ENSMUST00000025702.3 ENSMUST00000025702.4 ENSMUST00000025702.5 ENSMUST00000025702.6 ENSMUST00000025702.7 ENSMUST00000025702.8 ENSMUST00000025702.9 NM_026912 Q91WE1 SNX15_MOUSE uc008ghm.1 uc008ghm.2 uc008ghm.3 May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity). Homodimer. Interacts with SNX1, SNX2 and SNX4 (By similarity). Cytoplasm Membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate. Belongs to the sorting nexin family. nucleolus cytoplasm cytosol lipid binding protein transport membrane cytoplasmic vesicle membrane cytoplasmic vesicle phosphatidylinositol binding uc008ghm.1 uc008ghm.2 uc008ghm.3 
ENSMUST00000025704.3 Cdca5 ENSMUST00000025704.3 cell division cycle associated 5 (from RefSeq NM_026410.3) CDCA5_MOUSE ENSMUST00000025704.1 ENSMUST00000025704.2 NM_026410 Q78HI6 Q9CPY3 uc008ghh.1 uc008ghh.2 uc008ghh.3 Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. Interacts with the APC/C complex (By similarity). Interacts with the chromatin-bound cohesin complex; the interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component SMC3. Interacts (via the FGF motif) with PDS5A and PDS5B; the interaction is direct and prevents the interaction of PDS5A with WAPL. Nucleus Chromosome Cytoplasm Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CPY3-1; Sequence=Displayed; Name=2; IsoId=Q9CPY3-2; Sequence=VSP_014402; The KEN box is required for the association with the APC/C complex. Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPL by CDCA5 (By similarity). Ubiquitinated by the APC/C complex in G1, leading to its degradation. Belongs to the sororin family. mitotic cell cycle chromatin nuclear chromatin protein binding nucleus nucleoplasm chromosome cytoplasm double-strand break repair cell cycle mitotic sister chromatid cohesion mitotic chromosome condensation mitotic metaphase plate congression cohesin complex positive regulation of exit from mitosis macromolecular complex binding cell division regulation of cohesin loading uc008ghh.1 uc008ghh.2 uc008ghh.3 
ENSMUST00000025706.10 Tnfrsf25 ENSMUST00000025706.10 tumor necrosis factor receptor superfamily, member 25, transcript variant 1 (from RefSeq NM_001291010.2) B1AWN9 B1AWN9_MOUSE ENSMUST00000025706.1 ENSMUST00000025706.2 ENSMUST00000025706.3 ENSMUST00000025706.4 ENSMUST00000025706.5 ENSMUST00000025706.6 ENSMUST00000025706.7 ENSMUST00000025706.8 ENSMUST00000025706.9 NM_001291010 Tnfrsf25 uc056zyo.1 uc056zyo.2 Lacks conserved residue(s) required for the propagation of feature annotation. plasma membrane signal transduction membrane integral component of membrane uc056zyo.1 uc056zyo.2 
ENSMUST00000025707.9 Zfpl1 ENSMUST00000025707.9 zinc finger like protein 1, transcript variant 1 (from RefSeq NM_024231.4) ENSMUST00000025707.1 ENSMUST00000025707.2 ENSMUST00000025707.3 ENSMUST00000025707.4 ENSMUST00000025707.5 ENSMUST00000025707.6 ENSMUST00000025707.7 ENSMUST00000025707.8 NM_024231 Q9DB43 ZFPL1_MOUSE uc008ghg.1 uc008ghg.2 uc008ghg.3 uc008ghg.4 Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis- Golgi, possibly via its interaction with GOLGA2/GM130 (By similarity). Interacts with GOLGA2/GM130. Q9DB43; Q62839: Golga2; Xeno; NbExp=14; IntAct=EBI-7836139, EBI-618335; Golgi apparatus, cis-Golgi network membrane ; Single-pass membrane protein The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein. Phosphorylated. Belongs to the ZFPL1 family. protein binding Golgi apparatus biological_process membrane integral component of membrane vesicle-mediated transport metal ion binding uc008ghg.1 uc008ghg.2 uc008ghg.3 uc008ghg.4 
ENSMUST00000025711.13 Vps51 ENSMUST00000025711.13 VPS51 GARP complex subunit (from RefSeq NM_001081041.1) ENSMUST00000025711.1 ENSMUST00000025711.10 ENSMUST00000025711.11 ENSMUST00000025711.12 ENSMUST00000025711.2 ENSMUST00000025711.3 ENSMUST00000025711.4 ENSMUST00000025711.5 ENSMUST00000025711.6 ENSMUST00000025711.7 ENSMUST00000025711.8 ENSMUST00000025711.9 Ffr NM_001081041 Q0VF89 Q0VF90 Q3UK22 Q3UVL4 Q9CXM6 VPS51_MOUSE uc289qjp.1 uc289qjp.2 uc289qjp.3 Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome- derived carriers to the TGN. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (By similarity). Component of the endosome- associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (By similarity). EIPR1 interacts with both EARP and GARP complexes and mediates the recruitment of the GARP complex to the trans-Golgi network (By similarity). Interacts with STX6 (via N-terminus) (PubMed:30962439). Interacts with VPS50 and VPS54 in an EIPR1-independent manner (By similarity). Golgi apparatus, trans-Golgi network Recycling endosome Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UVL4-1; Sequence=Displayed; Name=2; IsoId=Q3UVL4-2; Sequence=VSP_036128, VSP_036129; Name=3; IsoId=Q3UVL4-3; Sequence=VSP_036126, VSP_036127; Belongs to the VPS51 family. Sequence=AAI18932.1; Type=Frameshift; Evidence=; GARP complex molecular_function nucleolus endosome Golgi apparatus trans-Golgi network cytosol lipid transport autophagy Golgi organization lysosomal transport protein transport membrane endocytic recycling retrograde transport, endosome to Golgi intracellular membrane-bounded organelle Golgi vesicle transport recycling endosome EARP complex uc289qjp.1 uc289qjp.2 uc289qjp.3 
ENSMUST00000025713.12 Tm7sf2 ENSMUST00000025713.12 transmembrane 7 superfamily member 2 (from RefSeq NM_028454.2) B5LBK0 ENSMUST00000025713.1 ENSMUST00000025713.10 ENSMUST00000025713.11 ENSMUST00000025713.2 ENSMUST00000025713.3 ENSMUST00000025713.4 ENSMUST00000025713.5 ENSMUST00000025713.6 ENSMUST00000025713.7 ENSMUST00000025713.8 ENSMUST00000025713.9 ERG24_MOUSE NM_028454 Q71KT5 uc008ggw.1 uc008ggw.2 uc008ggw.3 Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Reaction=4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH; Xref=Rhea:RHEA:18561, ChEBI:CHEBI:15378, ChEBI:CHEBI:17813, ChEBI:CHEBI:18364, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.70; Evidence=; Reaction=5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH = 5alpha- cholest-8-en-3beta-ol + NADP(+); Xref=Rhea:RHEA:46456, ChEBI:CHEBI:15378, ChEBI:CHEBI:16608, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:86131; Evidence=; Reaction=4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH = 4,4- dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+); Xref=Rhea:RHEA:46812, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78904, ChEBI:CHEBI:87044; Evidence=; Steroid biosynthesis; cholesterol biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Microsome membrane ; Multi- pass membrane protein Strongly expressed in liver, weaker in ovary, testis, kidney and brain. Mice develop normally, appear healthy and are fertile. Belongs to the ERG4/ERG24 family. nuclear inner membrane endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process steroid metabolic process cholesterol metabolic process membrane integral component of membrane sterol biosynthetic process oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor integral component of endoplasmic reticulum membrane organelle membrane intracellular membrane-bounded organelle receptor complex delta14-sterol reductase activity NADP binding oxidation-reduction process uc008ggw.1 uc008ggw.2 uc008ggw.3 
ENSMUST00000025714.9 Rpp30 ENSMUST00000025714.9 ribonuclease P/MRP 30 subunit, transcript variant 2 (from RefSeq NR_182659.1) ENSMUST00000025714.1 ENSMUST00000025714.2 ENSMUST00000025714.3 ENSMUST00000025714.4 ENSMUST00000025714.5 ENSMUST00000025714.6 ENSMUST00000025714.7 ENSMUST00000025714.8 NR_182659 O88796 RPP30_MOUSE Rnasep2 uc008hhg.1 uc008hhg.2 uc008hhg.3 uc008hhg.4 uc008hhg.5 Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Nucleus, nucleolus Belongs to the eukaryotic/archaeal RNase P protein component 3 family. ribonuclease MRP complex tRNA 5'-leader removal RNA binding catalytic activity ribonuclease P activity ribonuclease activity nucleus nucleolar ribonuclease P complex nucleolus rRNA processing tRNA processing hydrolase activity multimeric ribonuclease P complex ribonuclease P RNA binding RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc008hhg.1 uc008hhg.2 uc008hhg.3 uc008hhg.4 uc008hhg.5 
ENSMUST00000025719.5 Mlana ENSMUST00000025719.5 melan-A (from RefSeq NM_029993.1) ENSMUST00000025719.1 ENSMUST00000025719.2 ENSMUST00000025719.3 ENSMUST00000025719.4 Mlana NM_029993 Q2TA50 Q2TA50_MOUSE uc008hdx.1 uc008hdx.2 uc008hdx.3 uc008hdx.4 endoplasmic reticulum membrane Golgi apparatus trans-Golgi network membrane integral component of membrane melanosome uc008hdx.1 uc008hdx.2 uc008hdx.3 uc008hdx.4 
ENSMUST00000025727.6 Trpd52l3 ENSMUST00000025727.6 tumor protein D52-like 3 (from RefSeq NM_025741.2) ENSMUST00000025727.1 ENSMUST00000025727.2 ENSMUST00000025727.3 ENSMUST00000025727.4 ENSMUST00000025727.5 NM_025741 Q9CQ14 Q9CQ14_MOUSE Trpd52l3 uc008hee.1 uc008hee.2 uc008hee.3 Belongs to the TPD52 family. molecular_function cellular_component biological_process uc008hee.1 uc008hee.2 uc008hee.3 
ENSMUST00000025728.13 Frmd8 ENSMUST00000025728.13 FERM domain containing 8 (from RefSeq NM_026169.4) ENSMUST00000025728.1 ENSMUST00000025728.10 ENSMUST00000025728.11 ENSMUST00000025728.12 ENSMUST00000025728.2 ENSMUST00000025728.3 ENSMUST00000025728.4 ENSMUST00000025728.5 ENSMUST00000025728.6 ENSMUST00000025728.7 ENSMUST00000025728.8 ENSMUST00000025728.9 FRMD8_MOUSE NM_026169 Q3UFK8 Q8C7U3 Q8C7U5 Q99KB3 Q9CSY6 Q9DC30 uc008gfn.1 uc008gfn.2 uc008gfn.3 Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway (PubMed:29897333). By acting on iRhoms, involved in ADAM17- mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity). Interacts with iRhom proteins, including iRhom2/RHBDF2 (via cytoplasmic N-termini); this interaction leads to mutual protein stabilization (PubMed:29897336). Interacts with LRP6; this interaction affects LRP6-binding to AXIN1 (By similarity). Cytoplasm, cytosol Cell membrane Widely expressed (at protein level). Mutant mice are viable and fertile. molecular_function cytoplasm cytosol cytoskeleton plasma membrane membrane positive regulation of tumor necrosis factor secretion uc008gfn.1 uc008gfn.2 uc008gfn.3 
ENSMUST00000025729.12 Tnks2 ENSMUST00000025729.12 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (from RefSeq NM_001163635.1) ENSMUST00000025729.1 ENSMUST00000025729.10 ENSMUST00000025729.11 ENSMUST00000025729.2 ENSMUST00000025729.3 ENSMUST00000025729.4 ENSMUST00000025729.5 ENSMUST00000025729.6 ENSMUST00000025729.7 ENSMUST00000025729.8 ENSMUST00000025729.9 NM_001163635 Q3UES3 Q6P537 Q8BXH7 TNKS2_MOUSE Tank2 Tnks2 uc008hhu.1 uc008hhu.2 uc008hhu.3 Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly- ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta- catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity. Reaction=NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H(+).; EC=2.4.2.30; Evidence=; Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA- COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54425; Evidence=; Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58225; Evidence=; Oligomerizes and associates with TNKS. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of Grb14 and TRF1 with its ankyrin repeat region. Interacts with HIF1AN. Interacts with RNF146; this interaction leads to ubiquitination and proteasomal degradation. Interacts with NUMA1 (By similarity). Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein Nucleus Chromosome, telomere Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles (By similarity). Also found around the pericentriolar matrix of mitotic centromeres (By similarity). During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1 (By similarity). Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. Belongs to the ARTD/PARP family. Golgi membrane protein polyubiquitination pericentriolar material telomere maintenance chromosome, telomeric region NAD+ ADP-ribosyltransferase activity nucleus nuclear envelope chromosome cytoplasm Golgi apparatus protein ADP-ribosylation membrane Wnt signaling pathway transferase activity transferase activity, transferring glycosyl groups enzyme binding multicellular organism growth regulation of multicellular organism growth metal ion binding protein N-terminus binding perinuclear region of cytoplasm protein localization to chromosome, telomeric region protein poly-ADP-ribosylation protein auto-ADP-ribosylation positive regulation of canonical Wnt signaling pathway positive regulation of telomere capping negative regulation of telomere maintenance via telomere lengthening protein ADP-ribosylase activity uc008hhu.1 uc008hhu.2 uc008hhu.3 
ENSMUST00000025732.14 Slc25a45 ENSMUST00000025732.14 solute carrier family 25, member 45, transcript variant 1 (from RefSeq NM_134154.4) ENSMUST00000025732.1 ENSMUST00000025732.10 ENSMUST00000025732.11 ENSMUST00000025732.12 ENSMUST00000025732.13 ENSMUST00000025732.2 ENSMUST00000025732.3 ENSMUST00000025732.4 ENSMUST00000025732.5 ENSMUST00000025732.6 ENSMUST00000025732.7 ENSMUST00000025732.8 ENSMUST00000025732.9 NM_134154 Q3TC75 Q3UZE9 Q8CFJ7 Q8VBZ7 S2545_MOUSE uc008gfs.1 uc008gfs.2 uc008gfs.3 Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CFJ7-1; Sequence=Displayed; Name=2; IsoId=Q8CFJ7-2; Sequence=VSP_026250, VSP_026251; Widely expressed, with highest levels in testis, liver and kidney and low levels in brain, including cortex, cerebellum, hippocampus and hypothalamus, and heart. Belongs to the mitochondrial carrier (TC 2.A.29) family. Sequence=AAH22156.1; Type=Erroneous initiation; Evidence=; Sequence=BAE42082.1; Type=Frameshift; Evidence=; mitochondrion mitochondrial inner membrane acyl carnitine transport acyl carnitine transmembrane transporter activity membrane integral component of membrane transmembrane transporter activity transmembrane transport acyl carnitine transmembrane transport uc008gfs.1 uc008gfs.2 uc008gfs.3 
ENSMUST00000025739.14 Uhrf2 ENSMUST00000025739.14 ubiquitin-like, containing PHD and RING finger domains 2, transcript variant 8 (from RefSeq NR_185060.1) ENSMUST00000025739.1 ENSMUST00000025739.10 ENSMUST00000025739.11 ENSMUST00000025739.12 ENSMUST00000025739.13 ENSMUST00000025739.2 ENSMUST00000025739.3 ENSMUST00000025739.4 ENSMUST00000025739.5 ENSMUST00000025739.6 ENSMUST00000025739.7 ENSMUST00000025739.8 ENSMUST00000025739.9 NR_185060 Nirf Q7TMI3 Q8BG56 Q8BJP6 Q8BY30 Q8K1I5 UHRF2_MOUSE uc008hei.1 uc008hei.2 uc008hei.3 uc008hei.4 E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair. Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:23434322, PubMed:28402695). This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (PubMed:28115522). Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thus inducing G1 arrest. Ubiquitinates also PCNP leading to its degradation by the proteasome. Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation. Promotes also DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation. Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; E3 ligase activity is robustly activated by 5- hydroxy-methylcytosine. Protein modification; protein ubiquitination. Homodimer; disulfide-linked. Binds methylated CpG containing oligonucleotides. Interacts with H3; the interaction has a preference for the 'Lys-9' trimethylated form of H3 (H3K9me3) (By similarity). Interacts with PCNP. Interacts with HDAC1. Interacts directly with CCNE1; the interaction ubiquitinates CCNE1 and appears independent of CCNE1 phosphorylation. Interacts with CCND1; the interaction ubiquitinates CCND1 and appears independent of CCND1 phosphorylation. Interacts with p53/TP53 and RB1. Interacts with UBE2I. Interacts with ZNF618. Interacts with UHRF1. Interacts with FANCD2. Interacts with ATR. Interacts with PCNA (By similarity). Nucleus romosome Note=Enriched at genomic loci that are enriched for 5-hydroxy-methylcytosine (5hmC). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7TMI3-1; Sequence=Displayed; Name=2; IsoId=Q7TMI3-2; Sequence=VSP_013877, VSP_013878; Name=3; IsoId=Q7TMI3-3; Sequence=VSP_013876; Mostly detected in several tissues, including the thymus, spleen, lung, adrenal gland, and ovary. In addition, found in several tissues in the brain (cerebellum, hippocampus, and cerebral cortex). Up-regulated during cell differentiation. May be autoubiquitinated; which may lead to proteasomal degradation. Phosphorylated. Phosphorylation may be mediated by CDK2 (By similarity). Autosumoylated. Deletion mice are viable, fertile, and grossly normal (PubMed:28402695, PubMed:28115522). However, adult mice develop frequent spontaneous seizures and display abnormal electrical activities in brain (PubMed:28402695). In addition, they display reduced 5-hydroxymethylcytosine (5hmC) in genomic DNA in the brain together with impaired spatial memory acquisition and retention (PubMed:28115522). DNA binding ubiquitin-protein transferase activity nucleus nucleoplasm nuclear heterochromatin cell cycle maintenance of DNA methylation protein ubiquitination transferase activity cell differentiation histone binding metal ion binding protein autoubiquitination ubiquitin protein ligase activity positive regulation of cell cycle arrest uc008hei.1 uc008hei.2 uc008hei.3 uc008hei.4 
ENSMUST00000025740.8 Rad9a ENSMUST00000025740.8 RAD9 checkpoint clamp component A (from RefSeq NM_011237.2) ENSMUST00000025740.1 ENSMUST00000025740.2 ENSMUST00000025740.3 ENSMUST00000025740.4 ENSMUST00000025740.5 ENSMUST00000025740.6 ENSMUST00000025740.7 NM_011237 Q8QZZ3 Q9Z0F6 RAD9A_MOUSE Rad9 uc008fzh.1 uc008fzh.2 uc008fzh.3 Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.2; Evidence=; Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1 (By similarity). The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2 (By similarity). The 9-1-1 complex associates with the RAD17-RFC complex (By similarity). RAD9A interacts with BCL2L1, FEN1, RAD9B, ABL1, RPA1, ATAD5 and RPA2 (PubMed:15983387). Interacts with DNAJC7 (By similarity). Interacts with DNAJC7. Interacts (when phosphorylated) with TOPBP1 (By similarity). Nucleus Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated by PRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex. Phosphorylated at Ser-341 and Ser-385 by CK2, promoting interaction with TOPBP1. Belongs to the rad9 family. DNA damage checkpoint nuclease activity exonuclease activity protein binding nucleus nucleoplasm cytoplasm DNA repair cellular response to DNA damage stimulus 3'-5' exonuclease activity exodeoxyribonuclease III activity hydrolase activity SH3 domain binding enzyme binding protein kinase binding checkpoint clamp complex intra-S DNA damage checkpoint histone deacetylase binding cellular response to ionizing radiation nucleic acid phosphodiester bond hydrolysis positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage uc008fzh.1 uc008fzh.2 uc008fzh.3 
ENSMUST00000025743.7 Mrpl21 ENSMUST00000025743.7 mitochondrial ribosomal protein L21, transcript variant 2 (from RefSeq NM_001347420.2) D9Wsu149 ENSMUST00000025743.1 ENSMUST00000025743.2 ENSMUST00000025743.3 ENSMUST00000025743.4 ENSMUST00000025743.5 ENSMUST00000025743.6 NM_001347420 Q9CSH9 Q9D1N9 Q9D214 RM21_MOUSE uc008fwd.1 uc008fwd.2 uc008fwd.3 uc008fwd.4 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D1N9-1; Sequence=Displayed; Name=2; IsoId=Q9D1N9-2; Sequence=VSP_020975; Belongs to the bacterial ribosomal protein bL21 family. RNA binding structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation biological_process uc008fwd.1 uc008fwd.2 uc008fwd.3 uc008fwd.4 
ENSMUST00000025749.15 Rps6kb2 ENSMUST00000025749.15 ribosomal protein S6 kinase, polypeptide 2, transcript variant 1 (from RefSeq NM_021485.3) ENSMUST00000025749.1 ENSMUST00000025749.10 ENSMUST00000025749.11 ENSMUST00000025749.12 ENSMUST00000025749.13 ENSMUST00000025749.14 ENSMUST00000025749.2 ENSMUST00000025749.3 ENSMUST00000025749.4 ENSMUST00000025749.5 ENSMUST00000025749.6 ENSMUST00000025749.7 ENSMUST00000025749.8 ENSMUST00000025749.9 KS6B2_MOUSE NM_021485 Q9Z1M4 uc008fzb.1 uc008fzb.2 uc008fzb.3 uc008fzb.4 Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Cytoplasm Nucleus Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ribosomal protein S6 kinase activity ATP binding nucleus cytoplasm protein phosphorylation signal transduction kinase activity phosphorylation transferase activity TOR signaling intracellular signal transduction peptide binding protein kinase B signaling positive regulation of translational initiation uc008fzb.1 uc008fzb.2 uc008fzb.3 uc008fzb.4 
ENSMUST00000025751.11 Ighmbp2 ENSMUST00000025751.11 immunoglobulin mu DNA binding protein 2 (from RefSeq NM_009212.2) A0A0B4J1E3 A0A0B4J1E3_MOUSE ENSMUST00000025751.1 ENSMUST00000025751.10 ENSMUST00000025751.2 ENSMUST00000025751.3 ENSMUST00000025751.4 ENSMUST00000025751.5 ENSMUST00000025751.6 ENSMUST00000025751.7 ENSMUST00000025751.8 ENSMUST00000025751.9 Ighmbp2 NM_009212 uc008fwa.1 uc008fwa.2 uc008fwa.3 uc008fwa.4 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Belongs to the DNA2/NAM7 helicase family. tRNA binding nucleic acid binding DNA binding RNA binding ATP binding nucleus cytoplasm DNA-dependent ATPase activity transcription factor binding RNA-dependent ATPase activity zinc ion binding DNA duplex unwinding 5'-3' RNA helicase activity identical protein binding ribosome binding 5'-3' DNA helicase activity metal ion binding uc008fwa.1 uc008fwa.2 uc008fwa.3 uc008fwa.4 
ENSMUST00000025752.15 Pola2 ENSMUST00000025752.15 polymerase (DNA directed), alpha 2, transcript variant 4 (from RefSeq NR_177190.1) DPOA2_MOUSE ENSMUST00000025752.1 ENSMUST00000025752.10 ENSMUST00000025752.11 ENSMUST00000025752.12 ENSMUST00000025752.13 ENSMUST00000025752.14 ENSMUST00000025752.2 ENSMUST00000025752.3 ENSMUST00000025752.4 ENSMUST00000025752.5 ENSMUST00000025752.6 ENSMUST00000025752.7 ENSMUST00000025752.8 ENSMUST00000025752.9 NR_177190 P33611 Q8VDR3 uc008ggb.1 uc008ggb.2 uc008ggb.3 uc008ggb.4 Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). Component of the alpha DNA polymerase complex (also known as the alpha DNA polymerase-primase complex) consisting of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the primase complex subunits PRIM1 and PRIM2 respectively (By similarity). Within the complex, POLA1 directly interacts with PRIM2 (By similarity). P33611; P33609: Pola1; NbExp=5; IntAct=EBI-848759, EBI-688051; Nucleus. Phosphorylated in a cell cycle-dependent manner, in G2/M phase. Belongs to the DNA polymerase alpha subunit B family. DNA binding DNA-directed DNA polymerase activity protein binding nucleus nucleoplasm alpha DNA polymerase:primase complex cytosol DNA replication DNA replication initiation protein import into nucleus protein heterodimerization activity DNA biosynthetic process uc008ggb.1 uc008ggb.2 uc008ggb.3 uc008ggb.4 
ENSMUST00000025755.11 Dmrt1 ENSMUST00000025755.11 doublesex and mab-3 related transcription factor 1 (from RefSeq NM_015826.5) DMRT1_MOUSE ENSMUST00000025755.1 ENSMUST00000025755.10 ENSMUST00000025755.2 ENSMUST00000025755.3 ENSMUST00000025755.4 ENSMUST00000025755.5 ENSMUST00000025755.6 ENSMUST00000025755.7 ENSMUST00000025755.8 ENSMUST00000025755.9 NM_015826 Q19AV2 Q2TDQ9 Q6Y951 Q6Y953 Q9QZ37 Q9QZ59 Q9QZA4 uc012bju.1 uc012bju.2 uc012bju.3 Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis. Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Dmrt1a, Dmrt1a1, Dmrt1a2, Dmrt1a3; IsoId=Q9QZ59-1; Sequence=Displayed; Name=2; Synonyms=Dmrt1b, DMR1g, Dmrt1g; IsoId=Q9QZ59-2; Sequence=VSP_042965; Name=3; Synonyms=Dmrt1d; IsoId=Q9QZ59-3; Sequence=VSP_042963; Name=4; Synonyms=Dmrt1c; IsoId=Q9QZ59-4; Sequence=VSP_042964; Testis-specific. In adult testis, expressed in Sertoli cells in all regions of the seminiferous tubules. Expressed dynamically in premeiotic germ cells (spermatogonia), with high expression only in regions of the seminiferous tubule that are early in the spermatogenic cycle (at protein level). Expressed in all mitotic spermatogonia. Expression decreases with the onset of spermatogonial differentiation and disappears at the initiation of meiosis. Detected already at 9.5 dpc. At 10.5 dpc, expressed in the genital ridges of both sexes. At 14.5 dpc, during gonadal sexual differentiation, expression declines in the ovary, but is maintained in the testis, where it becomes restricted to Sertoli and germ cells in the developing seminiferous tubules of the testis. Accumulates primarily in Sertoli cells. From P1, appears in germ cells and reach high levels by P7, just before meiosis begins. From P7 through adult stage, present in Sertoli cells and undifferentiated germ cells, but not in differentiating germ cells. Severe defects in the adult testis with hypoplastic testes and disorganization of seminiferous tubules and absence of germ cells, due to pre-meiotic germ cell death in testes. Sertoli cell fail to differentiate. Female mutant mice have normal ovaries and are fertile. Depending on the strain background mice also show testis teratomas: deletion in 129/Sv strain causes a high incidence of teratomas, whereas these tumors do not form in C57BL/6J mutant mice. Deletion of Dmrt1 during fetal development causes postnatal Sertoli cells to lose male-promoting Sox9 and instead activation of female-promoting genes such as Foxl2, leading to reprogrammation of Sertoli cells into granulosa cells. As a consequence, theca cells form, estrogen is produced and germ cells appear feminized. Belongs to the DMRT family. negative regulation of transcription from RNA polymerase II promoter cell morphogenesis RNA polymerase II regulatory region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding male germ cell proliferation developmental process involved in reproduction DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated multicellular organism development spermatogenesis sex differentiation germ cell migration male gonad development cell differentiation male sex determination intracellular signal transduction identical protein binding protein homodimerization activity sequence-specific DNA binding negative regulation of meiotic nuclear division positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter male sex differentiation metal ion binding protein heterodimerization activity oocyte development Sertoli cell differentiation Sertoli cell development positive regulation of meiosis I regulation of nodal signaling pathway positive regulation of male gonad development uc012bju.1 uc012bju.2 uc012bju.3 
ENSMUST00000025759.9 Eif1ad ENSMUST00000025759.9 eukaryotic translation initiation factor 1A domain containing (from RefSeq NM_027236.2) EIF1A_MOUSE ENSMUST00000025759.1 ENSMUST00000025759.2 ENSMUST00000025759.3 ENSMUST00000025759.4 ENSMUST00000025759.5 ENSMUST00000025759.6 ENSMUST00000025759.7 ENSMUST00000025759.8 NM_027236 Q3THJ3 Q8K1C2 Q9D8F9 uc008gct.1 uc008gct.2 uc008gct.3 Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity). Interacts with GAPDH and STAT1. Nucleus Belongs to the EIF1AD family. RNA binding translation initiation factor activity nucleus translational initiation uc008gct.1 uc008gct.2 uc008gct.3 
ENSMUST00000025761.8 Cabp4 ENSMUST00000025761.8 calcium binding protein 4 (from RefSeq NM_144532.2) CABP4_MOUSE ENSMUST00000025761.1 ENSMUST00000025761.2 ENSMUST00000025761.3 ENSMUST00000025761.4 ENSMUST00000025761.5 ENSMUST00000025761.6 ENSMUST00000025761.7 NM_144532 Q8VHC5 uc008fyw.1 uc008fyw.2 uc008fyw.3 uc008fyw.4 Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages. Interacts with CACNA1F and CACNA1D (via IQ domain) in a calcium independent manner. Interacts (via N-terminus) with UNC119. Cytoplasm Presynapse Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors. Expressed in retina and in the inner hair cells (IHC) of the cochlea. Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity, but has no effect on calcium binding. calcium channel regulator activity calcium ion binding cytoplasm cytosol signal transduction visual perception phototransduction photoreceptor cell morphogenesis ion channel binding retinal cone cell development metal ion binding retinal bipolar neuron differentiation uc008fyw.1 uc008fyw.2 uc008fyw.3 uc008fyw.4 
ENSMUST00000025762.16 Banf1 ENSMUST00000025762.16 BAF nuclear assembly factor 1, transcript variant 1 (from RefSeq NM_011793.3) BAF_MOUSE Baf Banf1 ENSMUST00000025762.1 ENSMUST00000025762.10 ENSMUST00000025762.11 ENSMUST00000025762.12 ENSMUST00000025762.13 ENSMUST00000025762.14 ENSMUST00000025762.15 ENSMUST00000025762.2 ENSMUST00000025762.3 ENSMUST00000025762.4 ENSMUST00000025762.5 ENSMUST00000025762.6 ENSMUST00000025762.7 ENSMUST00000025762.8 ENSMUST00000025762.9 L2bp1 NM_011793 O54962 Q542E6 uc008gcs.1 uc008gcs.2 uc008gcs.3 uc008gcs.4 uc008gcs.5 Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA (By similarity). Contains two non-specific double-stranded DNA (dsDNA)- binding sites which promote DNA cross-bridging (By similarity). Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner (By similarity). Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface (By similarity). Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity (PubMed:32156810). Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses (By similarity). Also involved in DNA damage response: interacts with PARP1 in response to oxidative stress, thereby inhibiting the ADP- ribosyltransferase activity of PARP1 (By similarity). Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy (By similarity). Homodimer. Heterodimerizes with BANF2. Interacts with ANKLE2/LEM4, leading to decreased phosphorylation by VRK1 and promoting dephosphorylation by protein phosphatase 2A (PP2A). Binds non- specifically to double-stranded DNA, and is found as a hexamer or dodecamer upon DNA binding. Binds to LEM domain-containing nuclear proteins such as LEMD3/MAN1, TMPO/LAP2 and EMD (emerin). Interacts with ANKLE1 (via LEM domain); the interaction may favor BANF1 dimerization. Interacts with CRX and LMNA (lamin-A). Binds linker histone H1.1 and core histones H3. Interacts with LEMD2 (via LEM domain). Interacts with PARP1; interaction takes place in response to oxidative DNA damage. Nucleus Chromosome Nucleus envelope Cytoplasm Note=Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. The phosphorylated form (by VRK1) shows a cytoplasmic localization whereas the unphosphorylated form locates almost exclusively in the nucleus. May be included in HIV-1 virions via its interaction with viral GAG polyprotein. Has a helix-hairpin-helix (HhH) structural motif conserved among proteins that bind non-specifically to DNA. LEM domain proteins bind centrally on the BAF dimer. Ser-4 is the major site of phosphorylation as compared to Thr-2 and Thr-3. Phosphorylation on Thr-2; Thr-3 and Ser-4 disrupts its ability to bind DNA and reduces its ability to bind LEM domain- containing proteins. Non phosphorylated BAF seems to enhance binding between EMD and LMNA. Dephosphorylated by protein phosphatase 2A (PP2A) following interaction with ANKLE2/LEM4 during mitotic exit, leading to mitotic nuclear envelope reassembly. Belongs to the BAF family. condensed chromosome DNA binding nucleus nuclear envelope nucleoplasm chromosome cytoplasm cytosol chromosome segregation protein C-terminus binding DNA integration enzyme binding chromosome condensation identical protein binding protein homodimerization activity negative regulation of viral genome replication protein N-terminus binding establishment of integrated proviral latency LEM domain binding uc008gcs.1 uc008gcs.2 uc008gcs.3 uc008gcs.4 uc008gcs.5 
ENSMUST00000025764.6 Cst6 ENSMUST00000025764.6 cystatin E/M (from RefSeq NM_028623.5) Cst6 ENSMUST00000025764.1 ENSMUST00000025764.2 ENSMUST00000025764.3 ENSMUST00000025764.4 ENSMUST00000025764.5 NM_028623 Q9D1B1 Q9D1B1_MOUSE uc008gcq.1 uc008gcq.2 Secreted Belongs to the cystatin family. cornified envelope cysteine-type endopeptidase inhibitor activity epidermis development negative regulation of endopeptidase activity uc008gcq.1 uc008gcq.2 
ENSMUST00000025773.5 Pold4 ENSMUST00000025773.5 polymerase (DNA-directed), delta 4, transcript variant 1 (from RefSeq NM_027196.4) DPOD4_MOUSE ENSMUST00000025773.1 ENSMUST00000025773.2 ENSMUST00000025773.3 ENSMUST00000025773.4 NM_027196 Q9CWP8 uc008fzm.1 uc008fzm.2 uc008fzm.3 uc008fzm.4 uc008fzm.5 uc008fzm.6 As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break- induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites. Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival. Component of the tetrameric DNA polymerase delta complex (Pol- delta4), which consists of POLD1/p125, POLD2/p50, POLD3/p66/p68 and POLD4/p12, with POLD1 bearing DNA polymerase and 3' to 5' proofreading exonuclease activities. Within this complex, directly interacts with POLD1 and POLD2. Directly interacts with PCNA, as do POLD1 and POLD3; this interaction stimulates Pol-delta4 polymerase activity. As POLD1 and POLD2, directly interacts with WRNIP1; this interaction stimulates DNA polymerase delta-mediated DNA synthesis, independently of the presence of PCNA, possibly by increasing initiation frequency. Upon genotoxic stress induced by DNA damaging agents or by replication stress, POLD4 is proteolytically degraded and Pol-delta4 is converted into a trimeric form of the complex (Pol-delta3) that has an increased proofreading activity. The DNA polymerase delta complex interacts with POLDIP2; this interaction is probably mediated through direct binding to POLD2. Nucleus Note=Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation. In response to DNA damage or genotoxic stress, such as UV irradiation or treatment with an alkylating agent, protein expression drastically drops. Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination in response to UV irradiation or treatment with an alkylating agent, leading to proteasomal degradation. This modification is mediated, at least in part, by RNF8. Ubiquitinated; undergoes 'Lys-48'-linked ubiquitination in response to UV irradiation, leading to proteasomal degradation. This modification is partly mediated by RNF8 and by the DCX(DTL) E3 ubiquitin ligase complex (also called CRL4(CDT2)). Efficient degradation requires the presence of PCNA and is required for the inhibition of fork progression after DNA damage. Belongs to the DNA polymerase delta subunit 4 family. positive regulation of endothelial cell proliferation nucleus nucleolus mitochondrion cytosol DNA replication DNA-dependent DNA replication DNA repair cellular response to DNA damage stimulus delta DNA polymerase complex DNA biosynthetic process DNA-directed DNA polymerase activity uc008fzm.1 uc008fzm.2 uc008fzm.3 uc008fzm.4 uc008fzm.5 uc008fzm.6 
ENSMUST00000025774.11 Sf3b2 ENSMUST00000025774.11 splicing factor 3b, subunit 2, transcript variant 1 (from RefSeq NM_030109.2) A0A494B9S9 ENSMUST00000025774.1 ENSMUST00000025774.10 ENSMUST00000025774.2 ENSMUST00000025774.3 ENSMUST00000025774.4 ENSMUST00000025774.5 ENSMUST00000025774.6 ENSMUST00000025774.7 ENSMUST00000025774.8 ENSMUST00000025774.9 NM_030109 Q3UAI4 Q3UBH2 Q3UJB0 Q3UQU5 Q80W39 Q8BL33 Q9CS24 SF3B2_MOUSE Sf3b2 uc008gcm.1 uc008gcm.2 uc008gcm.3 uc008gcm.4 uc008gcm.5 Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre- mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs. Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Part of the SF3B subcomplex of the 17S U2 SnRNP complex. SF3B associates with the splicing subcomplex SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Within the SF3B complex, interacts directly with SF3B4. Found in a complex with PRMT9, SF3B2 and SF3B4. Interacts (Arg-491-methylated form) with SMN1 (via Tudor domain). Interacts with RBM7. Interacts with ERCC6. Component of the minor spliceosome. Within this complex, interacts with SCNM1 and CRIPT. Nucleus Nucleus speckle Methylation at Arg-491 by PRMT9 is required for the interaction with SMN1. mRNA splicing, via spliceosome protein binding nucleus spliceosomal complex U2 snRNP U12-type spliceosomal complex nuclear speck U2-type precatalytic spliceosome catalytic step 2 spliceosome uc008gcm.1 uc008gcm.2 uc008gcm.3 uc008gcm.4 uc008gcm.5 
ENSMUST00000025778.9 Gldc ENSMUST00000025778.9 glycine decarboxylase (from RefSeq NM_138595.3) ENSMUST00000025778.1 ENSMUST00000025778.2 ENSMUST00000025778.3 ENSMUST00000025778.4 ENSMUST00000025778.5 ENSMUST00000025778.6 ENSMUST00000025778.7 ENSMUST00000025778.8 GCSP_MOUSE Gldc NM_138595 Q91W43 uc008hej.1 uc008hej.2 uc008hej.3 uc008hej.4 uc008hej.5 The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity). Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]- L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304, Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099, ChEBI:CHEBI:83143; EC=1.4.4.2; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Stimulated by lipoic acid. Inhibited in presence of methylamine (By similarity). Interacts with GCSH (By similarity). Homodimer. The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH) (By similarity). Mitochondrion Belongs to the GcvP family. catalytic activity glycine dehydrogenase (decarboxylating) activity nucleus mitochondrion plasma membrane glycine cleavage complex cellular amino acid metabolic process glycine metabolic process glycine catabolic process oxidoreductase activity glycine binding lyase activity glycine decarboxylation via glycine cleavage system enzyme binding pyridoxal phosphate binding response to methylamine protein homodimerization activity protein dimerization activity oxidation-reduction process pyridoxal binding response to lipoic acid cellular response to leukemia inhibitory factor uc008hej.1 uc008hej.2 uc008hej.3 uc008hej.4 uc008hej.5 
ENSMUST00000025779.11 Cdk2ap2 ENSMUST00000025779.11 cyclin dependent kinase 2 associated protein 2 (from RefSeq NM_026373.4) CDKA2_MOUSE D19Ertd144e Doc1r ENSMUST00000025779.1 ENSMUST00000025779.10 ENSMUST00000025779.2 ENSMUST00000025779.3 ENSMUST00000025779.4 ENSMUST00000025779.5 ENSMUST00000025779.6 ENSMUST00000025779.7 ENSMUST00000025779.8 ENSMUST00000025779.9 NM_026373 Q9CPY4 uc008fym.1 uc008fym.2 uc008fym.3 Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (By similarity). Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (PubMed:22548356). Regulates microtubule organization of metaphase II oocytes (PubMed:12944431). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (By similarity). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (By similarity). Interacts with CDK2AP1 (By similarity). Interacts with CDK2 (By similarity). Interacts with MAPK1 (PubMed:12944431). Cytoplasm Nucleus Note=Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules. Oocytes (at protein level). Phosphorylated by MAPK1 and CDK2. Belongs to the CDK2AP family. protein binding nucleus cytoplasm microtubule regulation of microtubule cytoskeleton organization regulation of stem cell division negative regulation of G1/S transition of mitotic cell cycle uc008fym.1 uc008fym.2 uc008fym.3 
ENSMUST00000025786.9 Pacs1 ENSMUST00000025786.9 phosphofurin acidic cluster sorting protein 1, transcript variant 1 (from RefSeq NM_153129.4) ENSMUST00000025786.1 ENSMUST00000025786.2 ENSMUST00000025786.3 ENSMUST00000025786.4 ENSMUST00000025786.5 ENSMUST00000025786.6 ENSMUST00000025786.7 ENSMUST00000025786.8 NM_153129 PACS1_MOUSE Q6P5H8 Q8K212 uc008gcj.1 uc008gcj.2 uc008gcj.3 uc008gcj.4 Coat protein that is involved in the localization of trans- Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster- containing cytoplasmic domain of these molecules with the adapter- protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits (By similarity). Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (PubMed:33630350). Associates with AP-1 and AP-3 but not with AP-2 complexes (By similarity). Interacts with FURIN (PubMed:9695949). Forms a ternary complex with FURIN and AP-1 (By similarity). Interacts with PKD2 (via acidic region) (PubMed:15692563). Interacts with SORL1 (By similarity). Interacts with WDR37 (PubMed:33630350). Golgi apparatus, trans-Golgi network Note=Localizes in the perinuclear region, probably the TGN. Mice lacking PACS1 have reduced numbers of B-cell progenitors in the bone marrow starting at the pre-B cell stage, normal numbers of developing T-cell subpopulations in the thymus, and a reduction in splenic follicular B cells. ER Ca2+ efflux in PACS1- deficient lymphocytes is defective after antigen receptor stimulation, while ER stress and sensitivity to oxidative stress are increased. B cells have reduced IP3R expression, and show spontaneous loss of quiescence evidenced by increased proliferation and apoptosis in lymphocyte-replete environments in vivo. Belongs to the PACS family. Golgi apparatus COPI-coated vesicle positive regulation of protein binding protein localization to Golgi apparatus cellular protein localization ion channel binding perinuclear region of cytoplasm protein localization to plasma membrane uc008gcj.1 uc008gcj.2 uc008gcj.3 uc008gcj.4 
ENSMUST00000025797.7 Mbl2 ENSMUST00000025797.7 mannose-binding lectin (protein C) 2, transcript variant 1 (from RefSeq NM_010776.2) ENSMUST00000025797.1 ENSMUST00000025797.2 ENSMUST00000025797.3 ENSMUST00000025797.4 ENSMUST00000025797.5 ENSMUST00000025797.6 Mbl2 NM_010776 Q3UEK1 Q3UEK1_MOUSE uc008hel.1 uc008hel.2 uc008hel.3 uc008hel.4 complement activation, lectin pathway receptor binding mannose binding collagen trimer extracellular space carbohydrate binding innate immune response calcium-dependent protein binding negative regulation of viral process defense response to Gram-positive bacterium uc008hel.1 uc008hel.2 uc008hel.3 uc008hel.4 
ENSMUST00000025800.15 Pip5k1b ENSMUST00000025800.15 phosphatidylinositol-4-phosphate 5-kinase, type 1 beta (from RefSeq NM_008846.3) ENSMUST00000025800.1 ENSMUST00000025800.10 ENSMUST00000025800.11 ENSMUST00000025800.12 ENSMUST00000025800.13 ENSMUST00000025800.14 ENSMUST00000025800.2 ENSMUST00000025800.3 ENSMUST00000025800.4 ENSMUST00000025800.5 ENSMUST00000025800.6 ENSMUST00000025800.7 ENSMUST00000025800.8 ENSMUST00000025800.9 NM_008846 O70335 P70181 PI51B_MOUSE Pip5k1b Q8JZY6 uc008hap.1 uc008hap.2 uc008hap.3 Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:8798574, PubMed:9367159, PubMed:9535851, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments (PubMed:10679324). Contributes to the activation of phospholipase PLD2 (PubMed:11032811). Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (PubMed:18772378). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:14425, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.68; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14426; Evidence= Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero- 3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+); Xref=Rhea:RHEA:40363, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77136, ChEBI:CHEBI:77137, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40364; Evidence=; Reaction=1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D- myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl- sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+); Xref=Rhea:RHEA:40367, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77139, ChEBI:CHEBI:77140, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40368; Evidence=; Reaction=1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D- myo-inositol + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3- phospho-1D-myo-inositol 5-phosphate + ADP + H(+); Xref=Rhea:RHEA:40379, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77163, ChEBI:CHEBI:77164, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40380; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3- phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z,12Z)- octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+); Xref=Rhea:RHEA:40383, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77158, ChEBI:CHEBI:77159, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40384; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phospho-(1D-myo-inositol) + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+); Xref=Rhea:RHEA:40375, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77160, ChEBI:CHEBI:133606, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40376; Evidence=; Reaction=1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo- inositol + ATP = 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho- 1D-myo-inositol 5-phosphate + ADP + H(+); Xref=Rhea:RHEA:40387, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77165, ChEBI:CHEBI:77167, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40388; Evidence=; Activated by phosphatidic acid. Kinetic parameters: KM=34 uM for phosphatidylinositol-4-phosphate/PtdIns(4)P ; KM=27 uM for ATP ; KM=3.7 uM for 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phospho-1D-myo-inositol 4-phosphate ; KM=4.9 uM for 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3- phospho-1D-myo-inositol 4-phosphate ; Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1. P70181; Q9QYB1: Clic4; NbExp=4; IntAct=EBI-645167, EBI-645175; Cytoplasm, cytosol Cell membrane Endomembrane system Note=Associated with membranes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70181-1; Sequence=Displayed; Name=2; IsoId=P70181-2; Sequence=VSP_016012; Highly expressed in brain and testis. Barely detectable in liver and skeletal muscle. There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5- kinase type I alpha. nucleotide binding uropod protein binding ATP binding cytosol phosphatidylinositol biosynthetic process endomembrane system membrane kinase activity phosphatidylinositol phosphate kinase activity 1-phosphatidylinositol-4-phosphate 5-kinase activity phosphorylation transferase activity phosphatidylinositol metabolic process phosphatidylinositol phosphorylation uc008hap.1 uc008hap.2 uc008hap.3 
ENSMUST00000025802.10 Nudt8 ENSMUST00000025802.10 nudix (nucleoside diphosphate linked moiety X)-type motif 8 (from RefSeq NM_025529.3) ENSMUST00000025802.1 ENSMUST00000025802.2 ENSMUST00000025802.3 ENSMUST00000025802.4 ENSMUST00000025802.5 ENSMUST00000025802.6 ENSMUST00000025802.7 ENSMUST00000025802.8 ENSMUST00000025802.9 NM_025529 NUDT8_MOUSE Q3TDQ2 Q9CR24 uc008fyb.1 uc008fyb.2 uc008fyb.3 Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA and CoA esters yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products (PubMed:31004344). Hydrolyzes short- and medium-chain acyl-CoAs, exhibiting the highest activity toward free CoA, hexanoyl-CoA, and octanoyl-CoA and the lowest activity against acetyl-CoA (PubMed:31004344). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673). Reaction=an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'- phosphopantetheine + 2 H(+); Xref=Rhea:RHEA:50044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58342, ChEBI:CHEBI:58343, ChEBI:CHEBI:132023; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50045; Evidence=; Reaction=CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'- bisphosphate + 2 H(+); Xref=Rhea:RHEA:64988, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58343, ChEBI:CHEBI:61723; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64989; Evidence=; Reaction=acetyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S- acetyl-4'-phosphopantetheine; Xref=Rhea:RHEA:64992, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57288, ChEBI:CHEBI:58343, ChEBI:CHEBI:156266; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64993; Evidence=; Reaction=butanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:49976, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57371, ChEBI:CHEBI:58343, ChEBI:CHEBI:132011; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49977; Evidence=; Reaction=H2O + hexanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:49980, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58343, ChEBI:CHEBI:62620, ChEBI:CHEBI:132012; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49981; Evidence=; Reaction=H2O + octanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50016, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57386, ChEBI:CHEBI:58343, ChEBI:CHEBI:132013; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50017; Evidence=; Reaction=H2O + propanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:67464, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57392, ChEBI:CHEBI:58343, ChEBI:CHEBI:172362; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67465; Evidence=; Reaction=H2O + malonyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine; Xref=Rhea:RHEA:67468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57384, ChEBI:CHEBI:58343, ChEBI:CHEBI:172363; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67469; Evidence=; Reaction=H2O + succinyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine; Xref=Rhea:RHEA:67472, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57292, ChEBI:CHEBI:58343, ChEBI:CHEBI:172364; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67473; Evidence=; Reaction=a 5'-end CoA-ribonucleoside in mRNA + H2O = (R)-4'- phosphopantetheine + a 5'-end phospho-adenosine-phospho- ribonucleoside in mRNA + 2 H(+); Xref=Rhea:RHEA:67592, Rhea:RHEA- COMP:15719, Rhea:RHEA-COMP:17276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:61723, ChEBI:CHEBI:144051, ChEBI:CHEBI:172371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67593; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Kinetic parameters: KM=707 uM for acetyl-CoA ; KM=318 uM for propanol-CoA ; KM=224 uM for butanoyl-CoA ; KM=233 uM for malonyl-CoA ; KM=329 uM for succinyl-CoA ; KM=251 uM for hexanoyl-CoA ; Monomer. Mitochondrion Expressed at the highest levels in the kidneys, heart, brown adipose tissue and liver (at protein level) (PubMed:31004344). Expressed at lower levels in the brain, skeletal muscle, and white adipose tissue (at protein level) (PubMed:31004344). Belongs to the Nudix hydrolase family. mitochondrion biological_process hydrolase activity metal ion binding uc008fyb.1 uc008fyb.2 uc008fyb.3 
ENSMUST00000025803.9 Dkk1 ENSMUST00000025803.9 dickkopf WNT signaling pathway inhibitor 1 (from RefSeq NM_010051.3) DKK1_MOUSE ENSMUST00000025803.1 ENSMUST00000025803.2 ENSMUST00000025803.3 ENSMUST00000025803.4 ENSMUST00000025803.5 ENSMUST00000025803.6 ENSMUST00000025803.7 ENSMUST00000025803.8 NM_010051 O54908 Q80UL5 uc008hen.1 uc008hen.2 uc008hen.3 uc008hen.4 uc008hen.5 Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:18524778). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (PubMed:26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning (PubMed:18505822). Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling. Interacts with LRP6 (PubMed:18524778). Forms a ternary complex with LRP6 and KREM1. Interacts with KREM1 (By similarity). Secreted. Expressed in the developing brain, cochlea and limb buds. The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6. Triple knockout mice KREM1/KREM2/DKK1 exhibit enhanced growth of ectopic digits. Belongs to the dickkopf family. negative regulation of transcription from RNA polymerase II promoter cell morphogenesis involved in differentiation endoderm formation mesoderm formation hair follicle development regulation of receptor internalization protein binding extracellular region extracellular space plasma membrane multicellular organism development endoderm development learning or memory positive regulation of gene expression negative regulation of neuron projection development Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway negative regulation of ossification embryonic limb morphogenesis negative regulation of BMP signaling pathway forebrain development negative regulation of protein binding response to retinoic acid negative regulation of peptidyl-serine phosphorylation co-receptor binding negative regulation of mesodermal cell fate specification regulation of endodermal cell fate specification negative regulation of apoptotic process positive regulation of JUN kinase activity receptor antagonist activity low-density lipoprotein particle receptor binding regulation of synapse organization regulation of synaptic transmission, glutamatergic limb development head morphogenesis face morphogenesis negative regulation of pathway-restricted SMAD protein phosphorylation motor learning positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway Wnt signaling pathway involved in somitogenesis modulation of age-related behavioral decline negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment positive regulation of tau-protein kinase activity negative regulation of Wnt-Frizzled-LRP5/6 complex assembly positive regulation of midbrain dopaminergic neuron differentiation negative regulation of presynapse assembly negative regulation of receptor activity negative regulation of cardiac muscle cell differentiation uc008hen.1 uc008hen.2 uc008hen.3 uc008hen.4 uc008hen.5 
ENSMUST00000025804.7 Rab1b ENSMUST00000025804.7 RAB1B, member RAS oncogene family (from RefSeq NM_029576.3) ENSMUST00000025804.1 ENSMUST00000025804.2 ENSMUST00000025804.3 ENSMUST00000025804.4 ENSMUST00000025804.5 ENSMUST00000025804.6 NM_029576 Q3U0N1 Q9D1G1 RAB1B_MOUSE uc008gcf.1 uc008gcf.2 uc008gcf.3 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). Interacts with MICAL1 and MICAL2. Interacts (GTP-bound form) with MICALCL, MICAL1 and MILCAL3. Interacts with GDI1; the interaction requires the GDP-bound state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II. Interacts with RabGAP TBC1D20 (By similarity). Interacts (in GDP- bound form) with lipid phosphatase MTMR6 (via GRAM domain); the interaction regulates MTMR6 recruitment to the endoplasmic reticulum- Golgi intermediate compartment (PubMed:23188820). Interacts (in GDP- bound form) with lipid phosphatase MTMR7 (PubMed:23188820). Cytoplasm Membrane ; Lipid-anchor ; Cytoplasmic side Preautophagosomal structure membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasm, perinuclear region Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity). Co-localizes with MTMR6 to the endoplasmic reticulum- Golgi intermediate compartment and to the peri-Golgi region (By similarity). Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1). Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rab family. autophagosome assembly nucleotide binding GTPase activity GTP binding cytoplasm mitochondrion endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus intracellular protein transport ER to Golgi vesicle-mediated transport autophagy protein transport membrane virion assembly Rab protein signal transduction pre-autophagosomal structure membrane synapse perinuclear region of cytoplasm positive regulation of glycoprotein metabolic process regulation of autophagosome assembly uc008gcf.1 uc008gcf.2 uc008gcf.3 
ENSMUST00000025805.8 Cnih2 ENSMUST00000025805.8 cornichon family AMPA receptor auxiliary protein 2, transcript variant 1 (from RefSeq NM_009920.4) Cnih2 ENSMUST00000025805.1 ENSMUST00000025805.2 ENSMUST00000025805.3 ENSMUST00000025805.4 ENSMUST00000025805.5 ENSMUST00000025805.6 ENSMUST00000025805.7 NM_009920 Q3SYI8 Q3SYI8_MOUSE uc008gce.1 uc008gce.2 uc008gce.3 uc008gce.4 uc008gce.5 This gene encodes a protein that is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. This protein is similar to a Drosophila protein involved in anterior-posterior and dorsal-ventral patterning. Cnih2 conditional knockout mice exhibit reduced AMPA receptor synaptic transmission in the hippocampus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. Membrane ; Multi- pass membrane protein Belongs to the cornichon family. membrane integral component of membrane vesicle-mediated transport AMPA glutamate receptor complex synaptic transmission, glutamatergic regulation of membrane potential dendritic shaft postsynaptic membrane localization within membrane regulation of postsynaptic neurotransmitter receptor activity glutamatergic synapse integral component of postsynaptic density membrane negative regulation of receptor localization to synapse negative regulation of anterograde synaptic vesicle transport regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc008gce.1 uc008gce.2 uc008gce.3 uc008gce.4 uc008gce.5 
ENSMUST00000025806.5 Doc2g ENSMUST00000025806.5 double C2, gamma (from RefSeq NM_021791.3) A0A0R4J053 A0A0R4J053_MOUSE Doc2g ENSMUST00000025806.1 ENSMUST00000025806.2 ENSMUST00000025806.3 ENSMUST00000025806.4 NM_021791 uc008fyd.1 uc008fyd.2 uc008fyd.3 uc008fyd.4 membrane uc008fyd.1 uc008fyd.2 uc008fyd.3 uc008fyd.4 
ENSMUST00000025811.6 Yif1a ENSMUST00000025811.6 Yip1 interacting factor homolog A (S. cerevisiae) (from RefSeq NM_026553.4) ENSMUST00000025811.1 ENSMUST00000025811.2 ENSMUST00000025811.3 ENSMUST00000025811.4 ENSMUST00000025811.5 NM_026553 Q91XB7 Q9CWB2 YIF1A_MOUSE uc008gcd.1 uc008gcd.2 uc008gcd.3 uc008gcd.4 Possible role in transport between endoplasmic reticulum and Golgi. Interacts with YIPF5. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Note=Cycles between the endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediate compartment. Belongs to the YIF1 family. Sequence=BAB21972.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi membrane molecular_function endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus ER to Golgi vesicle-mediated transport protein transport membrane integral component of membrane vesicle-mediated transport ER to Golgi transport vesicle integral component of Golgi membrane endoplasmic reticulum-Golgi intermediate compartment membrane uc008gcd.1 uc008gcd.2 uc008gcd.3 uc008gcd.4 
ENSMUST00000025815.10 Zng1 ENSMUST00000025815.10 Zn regulated GTPase metalloprotein activator 1, transcript variant 2 (from RefSeq NR_033744.1) Cbwd1 ENSMUST00000025815.1 ENSMUST00000025815.2 ENSMUST00000025815.3 ENSMUST00000025815.4 ENSMUST00000025815.5 ENSMUST00000025815.6 ENSMUST00000025815.7 ENSMUST00000025815.8 ENSMUST00000025815.9 NR_033744 Q7TSA8 Q8K399 Q8VEH6 ZNG1_MOUSE uc008haw.1 uc008haw.2 uc008haw.3 uc008haw.4 Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (PubMed:35584702). Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation (PubMed:35584702). Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1 (PubMed:35584702). After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1 to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis (PubMed:35584702). GTP/GDP exchange is required for release of active METAP1 (PubMed:35584702). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VEH6-1; Sequence=Displayed; Name=2; IsoId=Q8VEH6-2; Sequence=VSP_019735; Present at high level in the nuclei of the ureteric bud cells in the developing kidneys. Although mice are viable and do not show visible phenotype, they display non-Mendelian inheritance (PubMed:35584702). Mice show impaired zinc homeostasis: they are sensitive to dietary zinc starvation and show decreased weight gain when fed a low zinc diet, due to failure to access existing zinc pools (PubMed:35584702). Impaired zinc homeostasis leads to mitochondrial dysfunction (PubMed:35584702). Mice also display kidney defects, characterized by hydronephrosis, hydroureters and duplicated ureters (PubMed:31862704). Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. nucleotide binding molecular_function ATP binding cellular_component biological_process uc008haw.1 uc008haw.2 uc008haw.3 uc008haw.4 
ENSMUST00000025818.8 Rin1 ENSMUST00000025818.8 Ras and Rab interactor 1, transcript variant 4 (from RefSeq NM_001425043.1) A0A2C9F2A2 A0A2C9F2A2_MOUSE ENSMUST00000025818.1 ENSMUST00000025818.2 ENSMUST00000025818.3 ENSMUST00000025818.4 ENSMUST00000025818.5 ENSMUST00000025818.6 ENSMUST00000025818.7 NM_001425043 Rin1 uc289qev.1 uc289qev.2 Belongs to the RIN (Ras interaction/interference) family. signal transduction uc289qev.1 uc289qev.2 
ENSMUST00000025823.6 Rce1 ENSMUST00000025823.6 Ras converting CAAX endopeptidase 1, transcript variant 11 (from RefSeq NR_160882.1) ENSMUST00000025823.1 ENSMUST00000025823.2 ENSMUST00000025823.3 ENSMUST00000025823.4 ENSMUST00000025823.5 FACE2_MOUSE Face2 NR_160882 P57791 Q9CSF8 Q9EP68 Rce1a uc008gak.1 uc008gak.2 uc008gak.3 uc008gak.4 Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K- Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (By similarity). Deubiquitination by USP17L2/USP17 negatively regulates the proteolytic activity toward Ras GTPases. Endoplasmic reticulum membrane ; Multi-pass membrane protein Ubiquitinated. Undergoes 'Lys-48'- and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains (By similarity). Mice show defective Ras processing and mislocalization of Ras within cells. Belongs to the peptidase U48 family. endopeptidase activity cysteine-type endopeptidase activity metalloendopeptidase activity endoplasmic reticulum endoplasmic reticulum membrane proteolysis peptidase activity membrane integral component of membrane hydrolase activity integral component of endoplasmic reticulum membrane CAAX-box protein processing uc008gak.1 uc008gak.2 uc008gak.3 uc008gak.4 
ENSMUST00000025827.10 Minpp1 ENSMUST00000025827.10 multiple inositol polyphosphate histidine phosphatase 1 (from RefSeq NM_010799.2) ENSMUST00000025827.1 ENSMUST00000025827.2 ENSMUST00000025827.3 ENSMUST00000025827.4 ENSMUST00000025827.5 ENSMUST00000025827.6 ENSMUST00000025827.7 ENSMUST00000025827.8 ENSMUST00000025827.9 MINP1_MOUSE MNCb-1572 Minpp1 Mipp NM_010799 Q3UA76 Q8VDR0 Q9JJD5 Q9Z2L6 uc008hfk.1 uc008hfk.2 uc008hfk.3 uc008hfk.4 Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo- inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed:10087200, PubMed:10938126). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant. By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis (PubMed:33257696). May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (By similarity). Reaction=1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate; Xref=Rhea:RHEA:16989, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57798, ChEBI:CHEBI:58130; EC=3.1.3.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16990; Evidence=; Reaction=1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo- inositol 1,2,5,6-tetrakisphosphate + phosphate; Xref=Rhea:RHEA:77115, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57798, ChEBI:CHEBI:195535; EC=3.1.3.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77116; Evidence=; Reaction=1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo- inositol 1,2,6-trisphosphate + phosphate; Xref=Rhea:RHEA:77119, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:195535, ChEBI:CHEBI:195537; EC=3.1.3.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77120; Evidence=; Reaction=1D-myo-inositol 1,2,6-trisphosphate + H2O = 1D-myo-inositol 1,2-bisphosphate + phosphate; Xref=Rhea:RHEA:77131, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:195537, ChEBI:CHEBI:195539; EC=3.1.3.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77132; Evidence=; Reaction=1D-myo-inositol 1,2-bisphosphate + H2O = 1D-myo-inositol 2- phosphate + phosphate; Xref=Rhea:RHEA:77135, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:84142, ChEBI:CHEBI:195539; EC=3.1.3.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77136; Evidence=; Reaction=1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate; Xref=Rhea:RHEA:20960, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58130, ChEBI:CHEBI:58747; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20961; Evidence=; Reaction=1D-myo-inositol 1,2,3,5,6-pentakisphosphate + H2O = 1D-myo- inositol 1,2,3,6-tetrakisphosphate + phosphate; Xref=Rhea:RHEA:77111, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58747, ChEBI:CHEBI:195534; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77112; Evidence=; Reaction=1D-myo-inositol 1,2,3,6-tetrakisphosphate + H2O = 1D-myo- inositol 1,2,3-trisphosphate + phosphate; Xref=Rhea:RHEA:77123, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:195534, ChEBI:CHEBI:195536; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77124; Evidence=; Reaction=1D-myo-inositol 1,2,3-trisphosphate + H2O = 1D-myo-inositol 2,3-bisphosphate + phosphate; Xref=Rhea:RHEA:77127, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:195536, ChEBI:CHEBI:195538; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77128; Evidence=; Reaction=1D-myo-inositol 2,3-bisphosphate + H2O = 1D-myo-inositol 2- phosphate + phosphate; Xref=Rhea:RHEA:77139, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:84142, ChEBI:CHEBI:195538; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77140; Evidence=; Reaction=1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo- inositol 1,4,5,6-tetrakisphosphate + phosphate; Xref=Rhea:RHEA:77143, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57627, ChEBI:CHEBI:57733; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77144; Evidence=; Reaction=1D-myo-inositol 1,4,5,6-tetrakisphosphate + H2O = 1D-myo- inositol 1,4,5-trisphosphate + phosphate; Xref=Rhea:RHEA:77147, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57627, ChEBI:CHEBI:203600; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77148; Evidence=; Reaction=(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate; Xref=Rhea:RHEA:27381, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58248, ChEBI:CHEBI:58289; EC=3.1.3.80; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27382; Evidence=; Endoplasmic reticulum lumen Secreted Cell membrane Note=Also associated with the plasma membrane in erythrocytes. Widely expressed with highest levels in kidney, intestine, thymus and liver. Expressed in different stages of embryogenesis, from 7.5 dpc through 14.5 dpc. The highest levels of expression is found in the visceral endoderm at 7.5 dpc and 8.5 dpc and in the fetal liver at 12.5 dpc and 14.5 dpc. N-glycosylated. Knockout mice are born at Mendelian ratio and are fertile. Although brain histology does not identify major differences in cerebellar or cerebral cortex architecture, a mild, but significant 10% decrease in the brain weight was identified associated with a reduced cortical thickness in homozygous mutant mice at postnatal day 21 (PubMed:33257696). At 14.5 dpc, neural progenitors show a decrease of about one third in intracellular free Ca(2+) levels compared to wild-type progenitors (PubMed:33257696). Normal chondrocyte differentiation and bone development are observed (PubMed:10938126). Belongs to the histidine acid phosphatase family. MINPP1 subfamily. Sequence=BAA95058.1; Type=Frameshift; Evidence=; acid phosphatase activity inositol-hexakisphosphate phosphatase activity endoplasmic reticulum endoplasmic reticulum lumen plasma membrane membrane dephosphorylation hydrolase activity phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity bisphosphoglycerate 3-phosphatase activity inositol phosphate phosphatase activity inositol hexakisphosphate 2-phosphatase activity uc008hfk.1 uc008hfk.2 uc008hfk.3 uc008hfk.4 
ENSMUST00000025830.9 Apba1 ENSMUST00000025830.9 amyloid beta precursor protein binding family A member 1 (from RefSeq NM_177034.3) APBA1_MOUSE Apba1 B2RUJ5 ENSMUST00000025830.1 ENSMUST00000025830.2 ENSMUST00000025830.3 ENSMUST00000025830.4 ENSMUST00000025830.5 ENSMUST00000025830.6 ENSMUST00000025830.7 ENSMUST00000025830.8 Mint1 NM_177034 Q3UH49 Q8BMF2 X11 mLin-10 uc008hai.1 uc008hai.2 uc008hai.3 Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of AAP-beta (By similarity). Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D- aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156). Part of a multimeric complex containing STXBP1 and STX1A. Interacts with STXBP1 (PubMed:21445306). Component of the brain- specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (PubMed:10846156). Within the complex, interacts (via PDZ domain) with the motor protein KIF17; the interaction is direct and is required for association of KIF17 with the cargo that is to be transported (PubMed:10846156). Binds to the cytoplasmic domain of amyloid protein (APP) (By similarity). Interacts (via PDZ 1 and 2 domains) with FSPB (By similarity). Isoform 3 interacts (via its truncated PID domain) with active, GTP-bound RAB6A. Also interacts with GTP-bound RAB6B (By similarity). Cytoplasm Cytoplasm, perinuclear region Nucleus [Isoform 3]: Golgi apparatus. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=B2RUJ5-1; Sequence=Displayed; Name=2; IsoId=B2RUJ5-2; Sequence=VSP_043763, VSP_043764; Name=3; Synonyms=Mint1_826; IsoId=B2RUJ5-3; Sequence=VSP_053519; Isoform 3 is expressed in brain. Composed of an N-terminal domain that binds Munc18-1 and LIN- 2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane. The autoinhibitory helix linker occludes the APP binding site. The PID domain, truncated by 11 amino acids, as observed in isoform 3, but not full-length, mediates the interaction with RAB6A. [Isoform 3]: This isoform interacts with RAB6 GTPases. beta-amyloid binding in utero embryonic development protein binding phosphatidylinositol-4,5-bisphosphate binding nucleus cytoplasm Golgi apparatus plasma membrane intracellular protein transport chemical synaptic transmission locomotory behavior synaptic vesicle regulation of gene expression glutamate secretion gamma-aminobutyric acid secretion protein transport membrane PDZ domain binding macromolecular complex multicellular organism growth dendritic spine macromolecular complex binding synapse perinuclear region of cytoplasm presynaptic active zone membrane macromolecular complex assembly glutamatergic synapse regulation of synaptic vesicle exocytosis uc008hai.1 uc008hai.2 uc008hai.3 
ENSMUST00000025831.8 Dock8 ENSMUST00000025831.8 dedicator of cytokinesis 8 (from RefSeq NM_028785.3) DOCK8_MOUSE ENSMUST00000025831.1 ENSMUST00000025831.2 ENSMUST00000025831.3 ENSMUST00000025831.4 ENSMUST00000025831.5 ENSMUST00000025831.6 ENSMUST00000025831.7 NM_028785 Q6KAM7 Q6PIS0 Q7TMQ5 Q8C147 Q8CAP6 Q8K105 Q9DBQ2 uc008hba.1 uc008hba.2 uc008hba.3 Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (PubMed:22461490, PubMed:25713392). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (By similarity). Interacts (via DOCKER domain) with GTPase CDC42; the interaction activates CDC42 by exchanging GDP for GTP (PubMed:22461490). The unphosphorylated form interacts (via DOCKER domain) with LRCH1 (via LRR repeats); the interaction prevents the association between DOCK8 and CDC42 (PubMed:28028151). Interacts with CCDC88B (By similarity). Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Enriched and co-localizes with GTPase CDC42 at the immunological synapse formed during T cell/antigen presenting cell cognate interaction. Translocates from the cytoplasm to the plasma membrane in response to chemokine CXCL12/SDF-1-alpha stimulation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C147-1; Sequence=Displayed; Name=2; IsoId=Q8C147-2; Sequence=VSP_027374, VSP_027375, VSP_027376; Expressed in T cells (PubMed:28028151). Expressed in bone marrow-derived dendritic cells (PubMed:25713392). The DOCKER domain is necessary and sufficient for the GEF activity. In response to chemokine CXCL12/SDF-1-alpha stimulation, phosphorylated by PRKCA/PKC-alpha which promotes DOCK8 dissociation from LRCH1. Strain C3H/HeJ mice harbor a point mutation in Dock8 which results in impaired dendritic cell migration. The mutation is not observed in strains CBA/J, C3H/HeOuJ or C3HeB/FeJ. Mice are viable and fertile (PubMed:22461490). The number of CD4(+) and CD8(+) T-cells are reduced by 50 percent in the spleen and peripheral lymph nodes (PubMed:22461490). The number of marginal zone B cells in the spleen are also reduced (PubMed:22461490). In response to an immune challenge, impaired migration of epidermal dendritic cells to the draining lymph nodes resulting in a failure to prime CD4(+) T-cells characterized by a lack of CD4(+) T-cell proliferation in lymph nodes and a lack of antigen-specific IgG antibody production (PubMed:25713392, PubMed:22461490). Belongs to the DOCK family. Sequence=AAH30316.2; Type=Erroneous initiation; Evidence=; Sequence=BAB23587.1; Type=Erroneous initiation; Evidence=; Sequence=BAC26219.2; Type=Erroneous initiation; Evidence=; Sequence=BAD21430.1; Type=Erroneous initiation; Evidence=; immunological synapse formation guanyl-nucleotide exchange factor activity protein binding cytoplasm plasma membrane small GTPase mediated signal transduction membrane cell leading edge leading edge membrane lamellipodium membrane dendritic cell migration cell projection positive regulation of GTPase activity memory T cell proliferation negative regulation of T cell apoptotic process positive regulation of establishment of T cell polarity cellular response to chemokine positive regulation of T cell migration uc008hba.1 uc008hba.2 uc008hba.3 
ENSMUST00000025834.15 Peli3 ENSMUST00000025834.15 pellino 3, transcript variant 1 (from RefSeq NM_172835.3) A0A0R4J057 A0A0R4J057_MOUSE ENSMUST00000025834.1 ENSMUST00000025834.10 ENSMUST00000025834.11 ENSMUST00000025834.12 ENSMUST00000025834.13 ENSMUST00000025834.14 ENSMUST00000025834.2 ENSMUST00000025834.3 ENSMUST00000025834.4 ENSMUST00000025834.5 ENSMUST00000025834.6 ENSMUST00000025834.7 ENSMUST00000025834.8 ENSMUST00000025834.9 NM_172835 Peli3 uc012bgq.1 uc012bgq.2 uc012bgq.3 uc012bgq.4 E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Belongs to the pellino family. protein polyubiquitination Toll signaling pathway regulation of Toll signaling pathway negative regulation of tumor necrosis factor-mediated signaling pathway protein ubiquitination transferase activity ubiquitin protein ligase activity negative regulation of extrinsic apoptotic signaling pathway uc012bgq.1 uc012bgq.2 uc012bgq.3 uc012bgq.4 
ENSMUST00000025835.6 Cpt1a ENSMUST00000025835.6 carnitine palmitoyltransferase 1a, liver (from RefSeq NM_013495.2) Cpt1a ENSMUST00000025835.1 ENSMUST00000025835.2 ENSMUST00000025835.3 ENSMUST00000025835.4 ENSMUST00000025835.5 NM_013495 Q7TQD5 Q7TQD5_MOUSE uc008fwf.1 uc008fwf.2 uc008fwf.3 uc008fwf.4 uc008fwf.5 Lipid metabolism; fatty acid beta-oxidation. Membrane ; Multi- pass membrane protein Mitochondrion outer membrane ; Multi-pass membrane protein Belongs to the carnitine/choline acetyltransferase family. long-chain fatty acid metabolic process carnitine O-palmitoyltransferase activity mitochondrion mitochondrial outer membrane glucose metabolic process triglyceride metabolic process carnitine metabolic process response to organic cyclic compound membrane integral component of membrane transferase activity transferase activity, transferring acyl groups epithelial cell differentiation integral component of mitochondrial outer membrane positive regulation of fatty acid beta-oxidation response to drug eating behavior identical protein binding intracellular membrane-bounded organelle regulation of fatty acid oxidation regulation of insulin secretion protein homooligomerization cellular response to fatty acid uc008fwf.1 uc008fwf.2 uc008fwf.3 uc008fwf.4 uc008fwf.5 
ENSMUST00000025836.6 Mrpl11 ENSMUST00000025836.6 mitochondrial ribosomal protein L11 (from RefSeq NM_025553.4) ENSMUST00000025836.1 ENSMUST00000025836.2 ENSMUST00000025836.3 ENSMUST00000025836.4 ENSMUST00000025836.5 NM_025553 Q3TJX7 Q9CQF0 RM11_MOUSE uc008gbt.1 uc008gbt.2 uc008gbt.3 uc008gbt.4 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uL11 family. ribosomal large subunit assembly structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation large ribosomal subunit rRNA binding large ribosomal subunit rRNA binding uc008gbt.1 uc008gbt.2 uc008gbt.3 uc008gbt.4 
ENSMUST00000025840.16 Tesmin ENSMUST00000025840.16 testis expressed metallothionein like, transcript variant 1 (from RefSeq NM_001039657.2) ENSMUST00000025840.1 ENSMUST00000025840.10 ENSMUST00000025840.11 ENSMUST00000025840.12 ENSMUST00000025840.13 ENSMUST00000025840.14 ENSMUST00000025840.15 ENSMUST00000025840.2 ENSMUST00000025840.3 ENSMUST00000025840.4 ENSMUST00000025840.5 ENSMUST00000025840.6 ENSMUST00000025840.7 ENSMUST00000025840.8 ENSMUST00000025840.9 MTL5_MOUSE Mtl5 NM_001039657 Q548K4 Q8VIE0 Q8VIE1 Q9WTJ6 uc008fwh.1 uc008fwh.2 uc008fwh.3 Essential for normal spermatogenesis and male fertility (PubMed:31916570). Required for the completion of meiosis in male germ cells (PubMed:31916570). Cytoplasm cleus te=Predominantly localized to the cytoplasm (PubMed:11803038, PubMed:12606435). Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc (PubMed:11803038, PubMed:12606435). [Isoform 1]: Cytoplasm [Isoform 2]: Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long , Tesmin-L ; IsoId=Q9WTJ6-1; Sequence=Displayed; Name=2; Synonyms=Short , Tesmin-S ; IsoId=Q9WTJ6-2; Sequence=VSP_035300; Expressed in spermatocytes and adult heart. Also expressed in fetal brain, heart, kidney and ovary. [Isoform 1]: Testis (at protein level). [Isoform 2]: Testis. Expressed as early as day 8, coincident with the entry of germ cells into meiosis. Expression then progressively increases. Expressed in the pachytene stage. Male mice are infertile due to arrested spermatogenesis at the pachytene stage. Belongs to the lin-54 family. Sequence=AAD24667.1; Type=Erroneous initiation; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated multicellular organism development spermatogenesis cell differentiation uc008fwh.1 uc008fwh.2 uc008fwh.3 
ENSMUST00000025844.6 Ctsw ENSMUST00000025844.6 cathepsin W (from RefSeq NM_009985.5) CtsW Ctsw ENSMUST00000025844.1 ENSMUST00000025844.2 ENSMUST00000025844.3 ENSMUST00000025844.4 ENSMUST00000025844.5 NM_009985 Q8C2M0 Q8C2M0_MOUSE uc008gdk.1 uc008gdk.2 uc008gdk.3 uc008gdk.4 uc008gdk.5 uc008gdk.6 This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. Expression of the encoded protein is upregulated following lymphocyte activation. Data from a human cell line suggests that the encoded enzyme may be important for viral entry into host cells. [provided by RefSeq, Aug 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK088375.1, AF014941.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Belongs to the peptidase C1 family. proteolysis cysteine-type peptidase activity uc008gdk.1 uc008gdk.2 uc008gdk.3 uc008gdk.4 uc008gdk.5 uc008gdk.6 
ENSMUST00000025847.7 Fibp ENSMUST00000025847.7 fibroblast growth factor (acidic) intracellular binding protein, transcript variant 1 (from RefSeq NM_001253832.1) ENSMUST00000025847.1 ENSMUST00000025847.2 ENSMUST00000025847.3 ENSMUST00000025847.4 ENSMUST00000025847.5 ENSMUST00000025847.6 Fibp NM_001253832 Q8K2D8 Q8K2D8_MOUSE uc008gdh.1 uc008gdh.2 uc008gdh.3 uc008gdh.4 nucleus membrane nuclear speck fibroblast growth factor binding uc008gdh.1 uc008gdh.2 uc008gdh.3 uc008gdh.4 
ENSMUST00000025850.7 Fosl1 ENSMUST00000025850.7 fos-like antigen 1 (from RefSeq NM_010235.2) ENSMUST00000025850.1 ENSMUST00000025850.2 ENSMUST00000025850.3 ENSMUST00000025850.4 ENSMUST00000025850.5 ENSMUST00000025850.6 Fosl1 NM_010235 Q3UMK5 Q3UMK5_MOUSE uc008gdc.1 uc008gdc.2 uc008gdc.3 uc008gdc.4 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter female pregnancy learning negative regulation of cell proliferation response to mechanical stimulus response to gravity response to organic cyclic compound response to progesterone response to cytokine response to drug response to hydrogen peroxide presynaptic membrane neuron projection positive regulation of apoptotic process intracellular membrane-bounded organelle positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity response to corticosterone response to cAMP pri-miRNA transcription from RNA polymerase II promoter positive regulation of DNA-templated transcription, initiation uc008gdc.1 uc008gdc.2 uc008gdc.3 uc008gdc.4 
ENSMUST00000025851.4 Dpp3 ENSMUST00000025851.4 dipeptidylpeptidase 3, transcript variant 1 (from RefSeq NM_133803.2) DPP3_MOUSE ENSMUST00000025851.1 ENSMUST00000025851.2 ENSMUST00000025851.3 NM_133803 Q8C0I6 Q99KK7 uc008gbo.1 uc008gbo.2 uc008gbo.3 Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg- beta-naphthylamide (in vitro). Reaction=Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.; EC=3.4.14.4; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Cytoplasm, cytosol Belongs to the peptidase M49 family. aminopeptidase activity cytoplasm cytosol plasma membrane proteolysis peptidase activity metallopeptidase activity dipeptidyl-peptidase activity zinc ion binding nuclear speck hydrolase activity metal ion binding uc008gbo.1 uc008gbo.2 uc008gbo.3 
ENSMUST00000025853.16 Drap1 ENSMUST00000025853.16 DR1 associated protein 1, transcript variant 2 (from RefSeq NM_024176.2) ENSMUST00000025853.1 ENSMUST00000025853.10 ENSMUST00000025853.11 ENSMUST00000025853.12 ENSMUST00000025853.13 ENSMUST00000025853.14 ENSMUST00000025853.15 ENSMUST00000025853.2 ENSMUST00000025853.3 ENSMUST00000025853.4 ENSMUST00000025853.5 ENSMUST00000025853.6 ENSMUST00000025853.7 ENSMUST00000025853.8 ENSMUST00000025853.9 NC2A_MOUSE NM_024176 Q9D6N5 uc008gcz.1 uc008gcz.2 uc008gcz.3 uc008gcz.4 The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity). Heterodimer with DR1. Binds BTAF1 (By similarity). Nucleus Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding. Belongs to the NC2 alpha/DRAP1 family. negative regulation of transcription from RNA polymerase II promoter DNA binding transcription cofactor activity transcription corepressor activity protein binding nucleus transcription factor binding identical protein binding protein heterodimerization activity uc008gcz.1 uc008gcz.2 uc008gcz.3 uc008gcz.4 
ENSMUST00000025856.17 Lrp5 ENSMUST00000025856.17 low density lipoprotein receptor-related protein 5 (from RefSeq NM_008513.3) E9QQ75 ENSMUST00000025856.1 ENSMUST00000025856.10 ENSMUST00000025856.11 ENSMUST00000025856.12 ENSMUST00000025856.13 ENSMUST00000025856.14 ENSMUST00000025856.15 ENSMUST00000025856.16 ENSMUST00000025856.2 ENSMUST00000025856.3 ENSMUST00000025856.4 ENSMUST00000025856.5 ENSMUST00000025856.6 ENSMUST00000025856.7 ENSMUST00000025856.8 ENSMUST00000025856.9 LRP5_MOUSE Lr3 Lrp5 Lrp7 NM_008513 O88883 Q91VN0 Q9R208 uc008fwq.1 uc008fwq.2 uc008fwq.3 uc008fwq.4 Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11956231). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (PubMed:15142971). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11956231). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (By similarity). Acts as a coreceptor for non- Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (By similarity). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (PubMed:11956231). Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling (PubMed:12581525). Component of a WNT- signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts with FZD8; the interaction is formed on WNT-binding and signaling. Interacts (via the phosphorylated PPPSP motif domains) with AXIN1; the interaction prevents inhibition of beta-catenin phosphorylation and signaling and is enhanced in the presence of GSK3B and WNT1 or WNT3A. Interacts (via beta-propeller regions 3 and 4) with DKK1; the interaction, enhanced by MESD and/or KREMEN, inhibits beta- catenin signaling by preventing GSK3-mediated phosphorylation of the PPPSP motifs and subsequent, AXIN1 binding. Interacts with CSNK1E. Interacts with SOST; the interaction antagonizes canonical Wnt signaling. Interacts with APCDD1 (By similarity). Interacts with MESD; the interaction prevents the formation of LRP5 aggregates, targets LRP5 to the plasma membrane and, when complexed with KREMEN2, increases DKK1 binding (PubMed:12581525). Interacts with CAPRIN2 (By similarity). Membrane ; Single- pass type I membrane protein Endoplasmic reticulum Note=Chaperoned to the plasma membrane by MESD. Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced.; Name=1; IsoId=Q91VN0-1; Sequence=Displayed; Widely expressed, with the highest expression levels in liver, heart, and lung and the lowest levels in brain and spleen. Expressed in early embryo throughout the ectoderm at 6.5 dpc and in visceral endoderm overlying the extraembryonic ectoderm at 7.5 dpc. Not present in the mesoderm nor in endoderm emerging from the primitive streak (PubMed:15142971). Expressed in differentiating osteoblasts that contribute to the lateral membranous part of clavicle at embryonic day 13.5. Expressed in osteoblasts lining the bony trabeculae of the humerus at embryonic day 16.5. Expressed in osteoblasts on both surfaces of the temporal bone at embryonic day 17.5 (PubMed:11719191). Phosphorylation of cytoplasmic PPPSP motifs regulates the signal transduction of the Wnt signaling pathway through acting as a docking site for AXIN1. Mice exhibit decreased osteoblast proliferation, developing low bone mass postnatally. Also display persistent embryonic eye vascularization due to a failure of macrophage-induced endothelial cell apoptosis. Mutant animals exhibit a loss of middle phalanx ossification at 18.5 dpc. LRP5 and LRP6 double null mutants are more severely affected. Embryos arrest prior to mid-gestation. Belongs to the LDLR family. gastrulation with mouth forming second vasculature development positive regulation of mesenchymal cell proliferation osteoblast development protein binding mitochondrion endoplasmic reticulum plasma membrane glucose catabolic process endocytosis multicellular organism development cholesterol metabolic process regulation of blood pressure positive regulation of cell proliferation response to radiation anterior/posterior pattern specification membrane integral component of membrane Wnt signaling pathway Wnt-protein binding positive regulation of osteoblast proliferation somatic stem cell population maintenance limb morphogenesis extracellular matrix-cell signaling cell migration involved in gastrulation cholesterol homeostasis embryonic digit morphogenesis Wnt-activated receptor activity regulation of apoptotic process receptor complex response to peptide hormone positive regulation of fat cell differentiation negative regulation of osteoblast differentiation positive regulation of osteoblast differentiation positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter bone remodeling bone marrow development positive regulation of sequence-specific DNA binding transcription factor activity anatomical structure regression retina morphogenesis in camera-type eye canonical Wnt signaling pathway bone development bone morphogenesis branching involved in mammary gland duct morphogenesis mammary gland duct morphogenesis adipose tissue development cell-cell signaling involved in mammary gland development regulation of insulin secretion involved in cellular response to glucose stimulus retina vasculature morphogenesis in camera-type eye retinal blood vessel morphogenesis negative regulation of protein serine/threonine kinase activity coreceptor activity involved in Wnt signaling pathway apoptotic process involved in blood vessel morphogenesis positive regulation of skeletal muscle acetylcholine-gated channel clustering uc008fwq.1 uc008fwq.2 uc008fwq.3 uc008fwq.4 
ENSMUST00000025861.3 Ovol1 ENSMUST00000025861.3 ovo like zinc finger 1 (from RefSeq NM_019935.3) ENSMUST00000025861.1 ENSMUST00000025861.2 NM_019935 OVOL1_MOUSE Q545S2 Q9WTJ2 uc008gdu.1 uc008gdu.2 uc008gdu.3 Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system. Nucleus. Expressed in skin, testis, kidney and weakly in lung. Not detected in heart, brain, spleen, liver and skeletal muscle. First expressed at 14.5 dpc in the suprabasal layers of developing epidermis, at 15.5 dpc expression begins in the inner cells of developing hair germs and restricted to inner root sheath and/or precortical cells of developing hair follicles. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding kidney development nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus spermatogenesis mesoderm development epidermis development epidermal cell differentiation sequence-specific DNA binding skin development negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding germline cell cycle switching, mitotic to meiotic cell cycle negative regulation of meiotic cell cycle phase transition negative regulation of stem cell proliferation uc008gdu.1 uc008gdu.2 uc008gdu.3 
ENSMUST00000025864.11 Rnaseh2c ENSMUST00000025864.11 ribonuclease H2, subunit C (from RefSeq NM_026616.2) Ayp1 ENSMUST00000025864.1 ENSMUST00000025864.10 ENSMUST00000025864.2 ENSMUST00000025864.3 ENSMUST00000025864.4 ENSMUST00000025864.5 ENSMUST00000025864.6 ENSMUST00000025864.7 ENSMUST00000025864.8 ENSMUST00000025864.9 NM_026616 Q8R1N2 Q9CQ18 RNH2C_MOUSE uc008gdx.1 uc008gdx.2 uc008gdx.3 Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C. Nucleus Belongs to the RNase H2 subunit C family. nucleus RNA catabolic process ribonuclease H2 complex uc008gdx.1 uc008gdx.2 uc008gdx.3 
ENSMUST00000025867.6 Rela ENSMUST00000025867.6 v-rel reticuloendotheliosis viral oncogene homolog A (avian), transcript variant 1 (from RefSeq NM_009045.5) ENSMUST00000025867.1 ENSMUST00000025867.2 ENSMUST00000025867.3 ENSMUST00000025867.4 ENSMUST00000025867.5 NM_009045 Q548Y4 Q548Y4_MOUSE Rela uc008gee.1 uc008gee.2 uc008gee.3 negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex cytoplasm cytosol acetaldehyde metabolic process regulation of transcription, DNA-templated inflammatory response aging transcription factor binding positive regulation of cell proliferation response to mechanical stimulus response to organic substance response to inorganic substance response to UV-B positive regulation of Schwann cell differentiation response to organic cyclic compound cytokine-mediated signaling pathway enzyme binding protein kinase binding chromatin DNA binding ubiquitin protein ligase binding positive regulation of chondrocyte differentiation response to lipopolysaccharide response to progesterone response to insulin macromolecular complex tumor necrosis factor-mediated signaling pathway response to cobalamin activating transcription factor binding response to cytokine NF-kappaB p50/p65 complex cellular response to vascular endothelial growth factor stimulus phosphate ion binding response to drug response to hydrogen peroxide identical protein binding protein homodimerization activity actinin binding histone deacetylase binding negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling response to amino acid response to morphine sequence-specific DNA binding regulation of DNA-templated transcription in response to stress transcription regulatory region DNA binding macromolecular complex binding synapse negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin receptor signaling pathway protein heterodimerization activity protein N-terminus binding positive regulation of T cell receptor signaling pathway NF-kappaB binding positive regulation of NF-kappaB transcription factor activity response to cAMP pri-miRNA transcription from RNA polymerase II promoter cellular response to hydrogen peroxide nucleotide-binding oligomerization domain containing 2 signaling pathway repressing transcription factor binding response to interleukin-1 NF-kappaB complex cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to peptidoglycan cellular response to nicotine cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor regulation of NIK/NF-kappaB signaling negative regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter cellular response to angiotensin positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of miRNA metabolic process negative regulation of extrinsic apoptotic signaling pathway uc008gee.1 uc008gee.2 uc008gee.3 
ENSMUST00000025875.5 Slc1a1 ENSMUST00000025875.5 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 (from RefSeq NM_009199.3) EAA3_MOUSE ENSMUST00000025875.1 ENSMUST00000025875.2 ENSMUST00000025875.3 ENSMUST00000025875.4 Eaac1 Eaat3 NM_009199 O35869 O35875 P51906 Q6P1F7 uc008hcm.1 uc008hcm.2 uc008hcm.3 Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:12119102, PubMed:18684713). Can also transport L-cysteine (PubMed:30840898). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:9233792). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (PubMed:9233792). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L- cysteine transport (PubMed:30840898). Negatively regulated by ARL6IP5 (PubMed:12119102). Reaction=H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:70699, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29985; Evidence=; Reaction=H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:70851, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29991; Evidence=; Reaction=D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) = D- aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in); Xref=Rhea:RHEA:71379, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29990; Evidence=; Homotrimer (Probable). Interacts with ARL6IP5 (PubMed:12119102, PubMed:18684713). Interacts with RTN2 (via N- terminus); the interaction promotes cell surface expression of SLC1A1 (By similarity). Interacts with SORCS2; this interaction is important for normal expression at the cell membrane (PubMed:30840898). P51906; P53702: Hccs; NbExp=5; IntAct=EBI-8580001, EBI-8579982; Cell membrane ulti-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Synapse, synaptosome Early endosome membrane Late endosome membrane Recycling endosome membrane Detected on neurons in the brain cortex, dentate gyrus and hippocampus CA2 region (at protein level) (PubMed:30840898). Expressed in whole brain, brain cortex, hippocampus, cerebellum, lung, kidney, small intestine and skeletal muscle (PubMed:30840898, PubMed:7766664, PubMed:9233792). Expressed in the renal outer medulla, medullary ray and cortex (at protein level) (PubMed:26739563). Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move. No visible phenotype at birth. Mice are born at the expected Mendelian rate, are viable and fertile, and do not develop any neurological symptoms with increasing age. They show decreased spontaneous locomotor activity. Besides, urinary excretion of glutamate and aspartate are strongly increased, but glutamate and aspartate serum levels are normal. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A1 subfamily. L-glutamate transmembrane transporter activity high-affinity glutamate transmembrane transporter activity protein binding endosome plasma membrane integral component of plasma membrane amino acid transport positive regulation of heart rate chloride transmembrane transporter activity symporter activity glutamate:sodium symporter activity L-glutamate transport membrane integral component of membrane apical plasma membrane glutamate binding cell junction early endosome membrane late endosome membrane cysteine transmembrane transporter activity identical protein binding cysteine transport neuron projection synapse metal ion binding protein homooligomerization L-glutamate import recycling endosome membrane D-aspartate import L-glutamate import across plasma membrane chloride transmembrane transport cysteine transmembrane transport uc008hcm.1 uc008hcm.2 uc008hcm.3 
ENSMUST00000025885.6 Znrd2 ENSMUST00000025885.6 zinc ribbon domain containing 2 (from RefSeq NM_020491.5) C184 ENSMUST00000025885.1 ENSMUST00000025885.2 ENSMUST00000025885.3 ENSMUST00000025885.4 ENSMUST00000025885.5 NM_020491 Q545N1 Q545N1_MOUSE uc008gfd.1 uc008gfd.2 uc008gfd.3 uc008gfd.4 uc008gfd.5 uc008gfd.1 uc008gfd.2 uc008gfd.3 uc008gfd.4 uc008gfd.5 
ENSMUST00000025893.7 Arl2 ENSMUST00000025893.7 ADP-ribosylation factor-like 2 (from RefSeq NM_019722.3) ARL2_MOUSE ENSMUST00000025893.1 ENSMUST00000025893.2 ENSMUST00000025893.3 ENSMUST00000025893.4 ENSMUST00000025893.5 ENSMUST00000025893.6 NM_019722 Q9D0J4 Q9WUM1 uc008gho.1 uc008gho.2 uc008gho.3 uc008gho.4 Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Found in a complex with ARL2, ARL2BP and SLC25A6. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with ELMOD2. The GTP-bound form interacts with ARL2BP. Interacts with TBCD; the GDP-bound form interacts preferentially with TBCD. Interacts with UNC119 (By similarity). Found in a complex with ARL2, ARL2BP and SLC25A4. The GTP-bound form interacts with PDE6D. Q9D0J4; O43924: PDE6D; Xeno; NbExp=6; IntAct=EBI-1033319, EBI-712685; Q9D0J4; Q13432: UNC119; Xeno; NbExp=2; IntAct=EBI-1033319, EBI-711260; Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules (By similarity). The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria. Expressed in brain, lung, cerebellum, liver, kidney, hippocampus, spleen, cortex and heart (at protein level). Not N-myristoylated. Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTPase activity protein binding GTP binding nucleus nucleolus cytoplasm mitochondrion mitochondrial intermembrane space Golgi apparatus centrosome microtubule organizing center cytosol cytoskeleton focal adhesion cell cycle centrosome cycle positive regulation of cell-substrate adhesion microtubule cytoskeleton acetylcholine transport lateral plasma membrane GDP binding regulation of microtubule polymerization positive regulation of microtubule polymerization negative regulation of GTPase activity maintenance of protein location in nucleus bicellular tight junction assembly uc008gho.1 uc008gho.2 uc008gho.3 uc008gho.4 
ENSMUST00000025897.13 Map4k2 ENSMUST00000025897.13 mitogen-activated protein kinase kinase kinase kinase 2, transcript variant 3 (from RefSeq NR_117093.1) ENSMUST00000025897.1 ENSMUST00000025897.10 ENSMUST00000025897.11 ENSMUST00000025897.12 ENSMUST00000025897.2 ENSMUST00000025897.3 ENSMUST00000025897.4 ENSMUST00000025897.5 ENSMUST00000025897.6 ENSMUST00000025897.7 ENSMUST00000025897.8 ENSMUST00000025897.9 M4K2_MOUSE NR_117093 Q61161 Rab8ip uc008gie.1 uc008gie.2 uc008gie.3 uc008gie.4 Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:8643544). Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N- terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway (By similarity). Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine- polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin (By similarity). To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2- mediated JNKs activation (By similarity). The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8 (By similarity). Enhances MAP3K1 oligomerization, which may relieve N- terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation (By similarity). Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3 (By similarity). May play a role in the regulation of vesicle targeting or fusion (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; The tumor necrosis factor (TNF), as well as endotoxins and pro-inflammatory stimuli such as polyinosine- polycytidine (poly(IC)), lipopolysaccharides (LPS), peptidoglycan (PGN), flagellin, or lipid A activate MAP4K2 by promoting its autophosphorylation. Interacts with TRAF2, TRAF6, MAP3K1/MEKK1 and MAP3K11/MLK3 (By similarity). Interacts with RAB8A. Cytoplasm Basolateral cell membrane ; Peripheral membrane protein Golgi apparatus membrane ; Peripheral membrane protein The PEST domains are Pro-, Glu-, Ser-, and Thr-rich domains. Proteins with PEST domains are frequently targets of degradation by the ubiquitin proteasome. Polyubiquitinated through 'Lys-48'-polyubiquitin chains, allowing proteasomal turnover. Ubiquitination requires the kinase activity of MAP4K2/GCK. Autophosphorylated in response to tumor necrosis factor (TNF), endotoxins or pro-inflammatory stimuli. Autophosphorylation leads to activation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Golgi membrane nucleotide binding activation of MAPKKK activity immune system process protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm Golgi apparatus plasma membrane protein phosphorylation vesicle targeting activation of JUN kinase activity MAP kinase kinase kinase kinase activity membrane kinase activity phosphorylation basolateral plasma membrane transferase activity signal transduction by protein phosphorylation mitogen-activated protein kinase kinase kinase binding activation of protein kinase activity intracellular signal transduction innate immune response positive regulation of JNK cascade uc008gie.1 uc008gie.2 uc008gie.3 uc008gie.4 
ENSMUST00000025904.12 Prdx5 ENSMUST00000025904.12 peroxiredoxin 5, transcript variant 1 (from RefSeq NM_012021.3) ENSMUST00000025904.1 ENSMUST00000025904.10 ENSMUST00000025904.11 ENSMUST00000025904.2 ENSMUST00000025904.3 ENSMUST00000025904.4 ENSMUST00000025904.5 ENSMUST00000025904.6 ENSMUST00000025904.7 ENSMUST00000025904.8 ENSMUST00000025904.9 NM_012021 P99029 PRDX5_MOUSE Prdx5 Prdx6 Q9QX45 Q9QZ75 uc008gjc.1 uc008gjc.2 uc008gjc.3 This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites may result in use of alternate in-frame translation start codons that generate alternate isoforms that are targeted to the mitochondrion or peroxisome/cytoplasm. [provided by RefSeq, Nov 2017]. Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]- disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.24; Evidence=; Monomer. P99029; P08228: Sod1; NbExp=2; IntAct=EBI-2735704, EBI-1635090; [Isoform Mitochondrial]: Mitochondrion [Isoform Cytoplasmic+peroxisomal]: Cytoplasm Peroxisome matrix Event=Alternative initiation; Named isoforms=2; Name=Mitochondrial; IsoId=P99029-1; Sequence=Displayed; Name=Cytoplasmic+peroxisomal; IsoId=P99029-2; Sequence=VSP_018830; Widely expressed. S-palmitoylated. Palmitoylation occurs on the active site, inhibiting its reactivity; therefore PRDX5 palmitoylation status determines its antioxidant capacity. [Isoform Mitochondrial]: S-palmitoylated. Depalmitoylated by ABHD10. The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys Prx, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin. Belongs to the peroxiredoxin family. Prx5 subfamily. RNA polymerase III regulatory region DNA binding peroxidase activity receptor binding protein binding nucleus cytoplasm mitochondrion peroxisome peroxisomal matrix cytosol apoptotic process response to oxidative stress thioredoxin peroxidase activity antioxidant activity negative regulation of transcription from RNA polymerase III promoter oxidoreductase activity cytoplasmic vesicle positive regulation of collagen biosynthetic process cellular response to oxidative stress cellular response to reactive oxygen species hydrogen peroxide catabolic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process intracellular membrane-bounded organelle cell redox homeostasis protein dimerization activity perinuclear region of cytoplasm negative regulation of oxidoreductase activity peroxiredoxin activity oxidation-reduction process regulation of apoptosis involved in tissue homeostasis NADPH oxidation peroxynitrite reductase activity cellular oxidant detoxification reactive nitrogen species metabolic process uc008gjc.1 uc008gjc.2 uc008gjc.3 
ENSMUST00000025906.12 Esrra ENSMUST00000025906.12 estrogen related receptor, alpha, transcript variant 1 (from RefSeq NM_007953.3) B2RRU9 ENSMUST00000025906.1 ENSMUST00000025906.10 ENSMUST00000025906.11 ENSMUST00000025906.2 ENSMUST00000025906.3 ENSMUST00000025906.4 ENSMUST00000025906.5 ENSMUST00000025906.6 ENSMUST00000025906.7 ENSMUST00000025906.8 ENSMUST00000025906.9 ERR1_MOUSE Err1 Estrra NM_007953 Nr3b1 O08580 Q3U110 uc008gjg.1 uc008gjg.2 Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium- chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle (By similarity). Binds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transcriptional activity of genes involved in energy metabolism. Interacts with PIAS4; the interaction enhances sumoylation (By similarity). Interacts with MAPK15; promotes re-localization of ESRRA to the cytoplasm through a XPO1-dependent mechanism then inhibits ESRRA transcriptional activity (PubMed:21190936). Nucleus toplasm Note=Co-localizes to the cytoplasm only in presence of MAPK15. Most highly expressed in kidney, heart, and brown adipocytes. Also found in uterus, cervix and vagina. Expressed in an organ specific manner through mid- to late embryonic development with persistent high-level expression in brown adipose tissue and intestinal mucosa. Activated by diethylstilbestrol (DES) and estradiol in the uterus. Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity. Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding (By similarity). Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys- 138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding (By similarity). No visible phenotype; mice are viable, fertile and display no gross anatomical alterations, with the exception of reduced body weight and peripheral fat deposits. Mice are resistant to a high-fat diet-induced obesity. Cardiomyocyte-specific double konckout for ESRRA and ESRRG are slower at gaining weight, smaller and shorter from 5 to 7 days of age compared to controls. They show decreased absolute weight of most internal organs except the heart. They have about 70% decreased plasma IGF1 levels but normal plasma growth hormone levels. At 14-15 days, mutants develop lethal dilated cardiomyopathy and heart failure (PubMed:28572090). Belongs to the nuclear hormone receptor family. NR3 subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding fibrillar center DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity steroid binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated zinc ion binding microtubule cytoskeleton protein domain specific binding regulation of ossification response to estradiol regulation of cell proliferation steroid hormone mediated signaling pathway sequence-specific DNA binding intercellular bridge regulation of osteoblast differentiation regulation of osteoclast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding cartilage development positive regulation of cellular response to insulin stimulus uc008gjg.1 uc008gjg.2 
ENSMUST00000025908.8 Kcnk4 ENSMUST00000025908.8 potassium channel, subfamily K, member 4, transcript variant 1 (from RefSeq NM_008431.4) ENSMUST00000025908.1 ENSMUST00000025908.2 ENSMUST00000025908.3 ENSMUST00000025908.4 ENSMUST00000025908.5 ENSMUST00000025908.6 ENSMUST00000025908.7 Kcnk4 NM_008431 Q0VD85 Q0VD85_MOUSE uc008gjj.1 uc008gjj.2 uc008gjj.3 uc008gjj.4 Membrane ; Multi- pass membrane protein Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. potassium channel activity integral component of plasma membrane ion transport memory membrane integral component of membrane potassium channel complex cellular response to mechanical stimulus cellular response to fatty acid cellular response to alkaline pH cellular response to temperature stimulus potassium ion transmembrane transport temperature-gated cation channel activity mechanically-gated potassium channel activity uc008gjj.1 uc008gjj.2 uc008gjj.3 uc008gjj.4 
ENSMUST00000025912.10 Plcb3 ENSMUST00000025912.10 phospholipase C, beta 3, transcript variant 3 (from RefSeq NR_177188.1) ENSMUST00000025912.1 ENSMUST00000025912.2 ENSMUST00000025912.3 ENSMUST00000025912.4 ENSMUST00000025912.5 ENSMUST00000025912.6 ENSMUST00000025912.7 ENSMUST00000025912.8 ENSMUST00000025912.9 NR_177188 P51432 PLCB3_MOUSE Plcb3 Q3UIS0 uc008gjr.1 uc008gjr.2 uc008gjr.3 uc008gjr.4 uc008gjr.5 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33180; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:43484, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57880, ChEBI:CHEBI:58433; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43485; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with SHANK2 (By similarity). Interacts with LPAR2 (By similarity). Cytoplasm Membrane Nucleus Note=And particulate fractions. Highly expressed in kidney, skeletal muscle, liver, lung, heart and brain. regulation of systemic arterial blood pressure phosphatidylinositol phospholipase C activity calcium ion binding calmodulin binding nucleus nucleoplasm cytosol lipid metabolic process post-Golgi vesicle-mediated transport signal transduction G-protein coupled receptor signaling pathway phosphoric diester hydrolase activity lipid catabolic process hydrolase activity phosphatidylinositol catabolic process inositol trisphosphate metabolic process inositol trisphosphate biosynthetic process macromolecular complex intracellular signal transduction sarcolemma phosphatidylinositol-mediated signaling release of sequestered calcium ion into cytosol postsynaptic cytosol uc008gjr.1 uc008gjr.2 uc008gjr.3 uc008gjr.4 uc008gjr.5 
ENSMUST00000025915.13 Dnajc4 ENSMUST00000025915.13 DnaJ heat shock protein family (Hsp40) member C4, transcript variant 7 (from RefSeq NM_001414719.1) Dnajc4 ENSMUST00000025915.1 ENSMUST00000025915.10 ENSMUST00000025915.11 ENSMUST00000025915.12 ENSMUST00000025915.2 ENSMUST00000025915.3 ENSMUST00000025915.4 ENSMUST00000025915.5 ENSMUST00000025915.6 ENSMUST00000025915.7 ENSMUST00000025915.8 ENSMUST00000025915.9 K3W4M1 K3W4M1_MOUSE NM_001414719 uc008gjy.1 uc008gjy.2 uc008gjy.3 uc008gjy.4 membrane integral component of membrane uc008gjy.1 uc008gjy.2 uc008gjy.3 uc008gjy.4 
ENSMUST00000025918.9 Stip1 ENSMUST00000025918.9 stress-induced phosphoprotein 1 (from RefSeq NM_016737.2) ENSMUST00000025918.1 ENSMUST00000025918.2 ENSMUST00000025918.3 ENSMUST00000025918.4 ENSMUST00000025918.5 ENSMUST00000025918.6 ENSMUST00000025918.7 ENSMUST00000025918.8 NM_016737 Q3TT16 Q60864 Q8BPH3 Q99L66 STIP1_MOUSE uc008gke.1 uc008gke.2 uc008gke.3 uc008gke.4 Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (By similarity). Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (PubMed:8999875). Interacts with PACRG. Interacts with EEF1AKMT3 (By similarity). Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction. Interacts with FLCN, FNIP1 and FNIP2. Interacts with HSPA8/HSC70 (By similarity). Interacts with HSP90AB1; upon SMYD2- dependent HSP90AB1 methylation (By similarity). Cytoplasm Nucleus Dynein axonemal particle The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90 (By similarity). In vitro kinase assay failed to detect phosphorylation by MAPKAPK2. protein binding nucleus cytoplasm cytosol protein C-terminus binding Hsp70 protein binding macromolecular complex myelin sheath chaperone binding Hsp90 protein binding cellular response to interleukin-7 uc008gke.1 uc008gke.2 uc008gke.3 uc008gke.4 
ENSMUST00000025924.4 Spindoc ENSMUST00000025924.4 spindlin interactor and repressor of chromatin binding, transcript variant 2 (from RefSeq NM_001167831.2) ENSMUST00000025924.1 ENSMUST00000025924.2 ENSMUST00000025924.3 NM_001167831 Q05AH6 Q3TI49 Q3TQH2 SPNDC_MOUSE Spindoc uc008gkv.1 uc008gkv.2 uc008gkv.3 uc008gkv.4 Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability (PubMed:29061846). Represses the expression of a number of SPIN1- regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway (PubMed:29061846). Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (By similarity). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). Interacts with SPIN1, SPIN2A, SPIN2B, SPIN3 and SPIN4. Interacts with TCF7L2 in a SPIN1-dependent manner. Interacts with PARP1; promoting PARP1 ADP-ribosyltransferase activity. Nucleus Chromosome Note=Colocalizes with PARP1 to sites of DNA damage. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q05AH6-1; Sequence=Displayed; Name=2; IsoId=Q05AH6-2; Sequence=VSP_031789, VSP_031790; Mice were born at the expected Mendelian rate and are viable (PubMed:34737271). Mice are however slightly smaller and display reduced levels of poly-ADP-ribosylation (PubMed:34737271). Moreover, they are hypersensitive to ionizing radiation-induced DNA damage (PubMed:34737271). molecular_function cellular_component negative regulation of transcription, DNA-templated uc008gkv.1 uc008gkv.2 uc008gkv.3 uc008gkv.4 
ENSMUST00000025925.11 Plaat3 ENSMUST00000025925.11 phospholipase A and acyltransferase 3, transcript variant 1 (from RefSeq NM_139269.2) B7X6T3 ENSMUST00000025925.1 ENSMUST00000025925.10 ENSMUST00000025925.2 ENSMUST00000025925.3 ENSMUST00000025925.4 ENSMUST00000025925.5 ENSMUST00000025925.6 ENSMUST00000025925.7 ENSMUST00000025925.8 ENSMUST00000025925.9 H-rev107 Hrasls3 Hrev107 NM_139269 PLAT3_MOUSE Pla2g16 Plaat3 Q3V3C3 Q8BWF7 Q8R3U1 uc008gli.1 uc008gli.2 Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19047760). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:18614531, PubMed:19047760, PubMed:19136964, PubMed:22134920). For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity). Shows N-acyltransferase activity,catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19047760). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (By similarity). Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (PubMed:33854238). Organelle membrane degradation is probably catalyzed by the phospholipase activity (PubMed:33854238). (Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm (PubMed:28077878). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18690; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40487, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:76078; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40488; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:38783, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73001, ChEBI:CHEBI:76071; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38784; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40571, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73003, ChEBI:CHEBI:76079; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40572; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + H2O = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3- phosphoethanolamine + H(+) + hexadecanoate; Xref=Rhea:RHEA:45164, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73008, ChEBI:CHEBI:76090; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45165; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40432; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phosphoethanolamine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41348, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73009, ChEBI:CHEBI:76091; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41349; Evidence=; Reaction=1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2- acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate; Xref=Rhea:RHEA:53496, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57875, ChEBI:CHEBI:137403; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53497; Evidence=; Reaction=1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1- hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:53500, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:78215, ChEBI:CHEBI:137403; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53501; Evidence=; Reaction=1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z- octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2- diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1- (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:53524, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:74667, ChEBI:CHEBI:138218, ChEBI:CHEBI:138220; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53525; Evidence=; Reaction=1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z- octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2- diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:53528, ChEBI:CHEBI:15378, ChEBI:CHEBI:74667, ChEBI:CHEBI:76078, ChEBI:CHEBI:138218, ChEBI:CHEBI:138222; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53529; Evidence=; Reaction=1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl- sn-glycero-3-phosphocholine = 1-hexanoyl-2-heptanoyl-sn-glycero-3- phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:54544, ChEBI:CHEBI:138197, ChEBI:CHEBI:138216, ChEBI:CHEBI:138266, ChEBI:CHEBI:138267; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54545; Evidence=; Reaction=1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate; Xref=Rhea:RHEA:56432, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:72998, ChEBI:CHEBI:73000; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56433; Evidence=; Reaction=1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:56436, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73000, ChEBI:CHEBI:76076; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56437; Evidence=; Reaction=1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:56440, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73858, ChEBI:CHEBI:75026; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56441; Evidence=; Reaction=1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate; Xref=Rhea:RHEA:56444, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:75026, ChEBI:CHEBI:76078; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56445; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn- glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40812; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40971, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73002, ChEBI:CHEBI:76084; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40972; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:56448, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669, ChEBI:CHEBI:76071; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56449; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:41384, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41385; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40923, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40924; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = H(+) + hexadecanoyl- sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:41360, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:78097; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41361; Evidence=; Reaction=1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn- glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:56428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28733, ChEBI:CHEBI:30245, ChEBI:CHEBI:42027; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56429; Evidence=; Kinetic parameters: KM=16 uM for 1-palmitoyl-2-linoleoyl-phosphatidylcholine (PC) ; Vmax=7.8 umol/min/mg enzyme with 1-palmitoyl-2-linoleoyl-PC as substrate (in the presence of 2 mM calcium) ; pH dependence: Optimum pH is 8.0. ; Interacts with PPP2R1A; this interaction might decrease PP2A activity. Cell membrane ; Single-pass membrane protein Cytoplasm Cytoplasm, cytosol Cytoplasm, perinuclear region Peroxisome membrane ; Single-pass membrane protein Mitochondrion membrane ; Single-pass membrane protein Nucleus envelope Lysosome membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Note=During eye lens differentiation, recruited from the cytosol to various organelles, including mitochondria, endoplasmic reticulum, nuclear envelope and lysosomes, immediately before organelle degradation. This translocation is triggered by organelle membrane damage and requires the C-terminal transmembrane domain. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R3U1-1; Sequence=Displayed; Name=2; IsoId=Q8R3U1-2; Sequence=VSP_013542; Ubiquitously expressed in normal tissues but down- regulated in primary carcinomas or in many cell lines derived from tumors (PubMed:12055182). Highly expressed in white adipose tissue and in adipocytes (PubMed:18614531, PubMed:19136964). Expressed at lower levels in brown adipose tissue (PubMed:18614531, PubMed:19136964). The C-terminal transmembrane domain is required for the targeting of the protein to damaged organelles. Mice display resistance to diet-induced obesity: they show strongly reduced adipose tissue mass and triglyceride content but normal adipogenesis accompanied by higher energy expenditure and increased fatty acid oxidation in adipocytes (PubMed:19136964). Mice show resistance to infection by picornaviruses, such as coxsackievirus A10, probably due to reduced viral genome release into the host cytoplasm (PubMed:28077878). The eye lens of knockout animals shows no growth defect, but the degradation of mitochondria, the endoplasmic reticulum and lysosomes is almost completely suppressed at postnatal day 0.5 and at 2 months and membranous organelles persisted at this time point (PubMed:33854238). Belongs to the H-rev107 family. Name=Protein Spotlight; Note=The makings of transparency - Issue 241 of November 2021; URL="https://web.expasy.org/spotlight/back_issues/241/"; phospholipase A2 activity cytoplasm peroxisome peroxisomal membrane endoplasmic reticulum plasma membrane lipid metabolic process triglyceride metabolic process phospholipid metabolic process peroxisome organization phospholipid biosynthetic process phosphatidylcholine 1-acylhydrolase activity response to bacterium membrane integral component of membrane lipid catabolic process N-acyltransferase activity transferase activity hydrolase activity negative regulation of cell cycle ether lipid metabolic process perinuclear region of cytoplasm phosphatidylserine 1-acylhydrolase activity 1-acyl-2-lysophosphatidylserine acylhydrolase activity N-acylphosphatidylethanolamine metabolic process regulation of adipose tissue development transferase activity, transferring acyl groups uc008gli.1 uc008gli.2 
ENSMUST00000025929.12 Plaat5 ENSMUST00000025929.12 phospholipase A and acyltransferase 5, transcript variant 1 (from RefSeq NM_025731.3) ENSMUST00000025929.1 ENSMUST00000025929.10 ENSMUST00000025929.11 ENSMUST00000025929.2 ENSMUST00000025929.3 ENSMUST00000025929.4 ENSMUST00000025929.5 ENSMUST00000025929.6 ENSMUST00000025929.7 ENSMUST00000025929.8 ENSMUST00000025929.9 Hrasls5 Hrlp5 NM_025731 PLAT5_MOUSE Plaat5 Q6P8Y6 Q9CPX5 Q9CVQ2 Q9CVS0 uc008gln.1 uc008gln.2 uc008gln.3 Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N- acylphosphatidylethanolamine (NAPE), which serves as precursor for N- acylethanolamines (NAEs) (PubMed:19000777). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1- hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3- phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn- glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45476, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003, ChEBI:CHEBI:74986, ChEBI:CHEBI:85277; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45477; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn- glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45176, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:78097; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45177; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn- glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45172, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:76078, ChEBI:CHEBI:78097; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45173; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn- glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45192, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:62537, ChEBI:CHEBI:64612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45193; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn- glycero-3-phosphoethanolamine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45188, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875, ChEBI:CHEBI:62537, ChEBI:CHEBI:64612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45189; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1- hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z- octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:56504, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001, ChEBI:CHEBI:74986, ChEBI:CHEBI:85291; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56505; Evidence=; Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9CPX5-1; Sequence=Displayed; Name=2; IsoId=Q9CPX5-2; Sequence=VSP_007450; Name=3; IsoId=Q9CPX5-3; Sequence=VSP_044623, VSP_007448, VSP_007449; Name=4; IsoId=Q9CPX5-4; Sequence=VSP_044623; Isoform 4 shows highest expression level in testis. Belongs to the H-rev107 family. phospholipase A2 activity phosphatidylcholine 1-acylhydrolase activity N-acyltransferase activity transferase activity transferase activity, transferring acyl groups hydrolase activity phosphatidylserine 1-acylhydrolase activity 1-acyl-2-lysophosphatidylserine acylhydrolase activity N-acylphosphatidylethanolamine metabolic process uc008gln.1 uc008gln.2 uc008gln.3 
ENSMUST00000025930.10 Smc3 ENSMUST00000025930.10 structural maintenance of chromosomes 3 (from RefSeq NM_007790.3) Bam Bmh Cspg6 ENSMUST00000025930.1 ENSMUST00000025930.2 ENSMUST00000025930.3 ENSMUST00000025930.4 ENSMUST00000025930.5 ENSMUST00000025930.6 ENSMUST00000025930.7 ENSMUST00000025930.8 ENSMUST00000025930.9 Mmip1 NM_007790 O35667 Q9CW03 Q9QUS3 SMC3_MOUSE Smc3l1 Smcd uc008hwy.1 uc008hwy.2 uc008hwy.3 uc008hwy.4 Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. Forms a heterodimer with SMC1A or SMC1B in cohesin complexes (PubMed:11564881). Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their SMC hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Also found in meiosis-specific cohesin complexes. Found in a complex with SMC1A, CDCA5 and RAD21, PDS5A/SCC-112 and PDS5B/APRIN. Interacts with PDS5A and WAPL; regulated by SMC3 acetylation. Interacts with NUMA1, and forms a ternary complex with KIF3B and KIFAP3, suggesting a function in tethering the chromosomes to the spindle pole and a function in chromosome movement. Interacts with SYCP2 and RPGR. Interacts (via SMC hinge domain) with KIAA1328 (via N- and C-terminal domains). Interacts with DDX11. The cohesin complex interacts with the cohesin loading complex subunits NIPBL/Scc2 (via HEAT repeats) and MAU2/Scc4. NIPBL directly contacts all members of the complex, RAD21, SMC1A/B, SMC3 and STAG1 (By similarity). Interacts with MXI1, MXD3 and MXD4 (PubMed:9528857). Interacts with STAG3 (PubMed:11483963). Interacts with the NuRD complex component HDAC2; the interaction is direct (By similarity). Q9CW03; Q9Z2D6: Mecp2; NbExp=3; IntAct=EBI-2550068, EBI-1188816; Nucleus Chromosome Chromosome, centromere Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions. Spermatocytes (at protein level). Widely expressed, with higher expression in testis and brain. The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC1A or SMC1B, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity). Phosphorylated at Ser-1083 in a SPO11-dependent manner. Acetylation at Lys-105 and Lys-106 by ESCO1 is important for genome stability and S phase sister chromatid cohesion. Regulated by DSCC1, it is required for processive DNA synthesis, coupling sister chromatid cohesion establishment during S phase to DNA replication (By similarity). Deacetylation by HDAC8, regulates release of the cohesin complex from chromatin (By similarity). Ubiquitinated by the DCX(DCAF15) complex, leading to its degradation. Belongs to the SMC family. SMC3 subfamily. Was originally isolated as a proteoglycan protein (explaining its name). Although not excluded, such secreted function is not clear. Sequence=CAA75400.1; Type=Frameshift; Evidence=; nucleotide binding chromosome, centromeric region chromatin lateral element chromatin binding protein binding ATP binding basement membrane nucleus nucleoplasm chromosome regulation of DNA replication DNA repair cellular response to DNA damage stimulus cell cycle sister chromatid cohesion cohesin complex nuclear matrix stem cell population maintenance meiotic cohesin complex negative regulation of DNA endoreduplication nuclear meiotic cohesin complex mediator complex binding positive regulation by host of viral release from host cell protein heterodimerization activity beta-tubulin binding chromosome organization cell division meiotic cell cycle interaction with symbiont dynein complex binding mitotic spindle pole regulation of mitotic spindle assembly uc008hwy.1 uc008hwy.2 uc008hwy.3 uc008hwy.4 
ENSMUST00000025936.12 Tectb ENSMUST00000025936.12 tectorin beta (from RefSeq NM_009348.4) ENSMUST00000025936.1 ENSMUST00000025936.10 ENSMUST00000025936.11 ENSMUST00000025936.2 ENSMUST00000025936.3 ENSMUST00000025936.4 ENSMUST00000025936.5 ENSMUST00000025936.6 ENSMUST00000025936.7 ENSMUST00000025936.8 ENSMUST00000025936.9 NM_009348 Q1HL20 Q1HL20_MOUSE Tectb uc008hxm.1 uc008hxm.2 extracellular region uc008hxm.1 uc008hxm.2 
ENSMUST00000025940.7 C1qtnf9 ENSMUST00000025940.7 C1q and tumor necrosis factor related protein 9 (from RefSeq NM_183175.4) C1QT9_MOUSE ENSMUST00000025940.1 ENSMUST00000025940.2 ENSMUST00000025940.3 ENSMUST00000025940.4 ENSMUST00000025940.5 ENSMUST00000025940.6 NM_183175 Q4ZJN1 Q8BZS3 uc007uff.1 uc007uff.2 uc007uff.3 Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. Multimers (predominantly trimers). Interacts with ADIPOQ via the C1q domain to form a heterotrimeric complex. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q4ZJN1-1; Sequence=Displayed; Name=2; IsoId=Q4ZJN1-2; Sequence=VSP_026218; Expressed predominantly in adipose tissue. Females express higher levels than males. The isomeric forms of the hydroxylated amino acids could not be determined in the mass-spectrometric methods reported in PubMed:18787108 but are assumed on the basis of their occurrence in collagen-like domains. Overexpression of CTRP9 in obese (ob/ob) mice significantly lowered serum glucose levels. hormone activity protein binding extracellular region collagen trimer extracellular space signal transduction fatty acid oxidation identical protein binding negative regulation of cell size positive regulation of protein serine/threonine kinase activity energy homeostasis positive regulation of cellular response to insulin stimulus uc007uff.1 uc007uff.2 uc007uff.3 
ENSMUST00000025944.9 Hhex ENSMUST00000025944.9 hematopoietically expressed homeobox (from RefSeq NM_008245.3) ENSMUST00000025944.1 ENSMUST00000025944.2 ENSMUST00000025944.3 ENSMUST00000025944.4 ENSMUST00000025944.5 ENSMUST00000025944.6 ENSMUST00000025944.7 ENSMUST00000025944.8 HHEX_MOUSE NM_008245 P43120 Prh Prhx Q544N6 Q9CRV1 Q9R1X2 uc008hio.1 uc008hio.2 uc008hio.3 Recognizes the DNA sequence 5'-ATTAA-3' (PubMed:10804173). Transcriptional repressor (PubMed:10804173). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:16936074). Establishes anterior identity at two levels; acts early to enhance canonical WNT- signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (PubMed:16936074). Inhibits EIF4E-mediated mRNA nuclear export (By similarity). May play a role in hematopoietic differentiation (PubMed:8096636). Interacts with CD81; the interaction prevents nuclear translocation of HHEX (PubMed:23665349). Interacts (via N-terminus) with SOX13; abolishes the SOX13-mediated inhibition of WNT-mediated transcriptional activity via competitive inhibition of the SOX13-TCF7 complex (PubMed:20028982). Interacts with EIF4E; the interaction inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). Nucleus Nucleus, nuclear body Cytoplasm Expressed during hematopoiesis. Sequence=BAB29163.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding vasculogenesis in utero embryonic development liver development morphogenesis of an epithelium myeloid leukocyte differentiation DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter mRNA export from nucleus signal transduction Notch signaling pathway multicellular organism development endoderm development transcription factor binding eukaryotic initiation factor 4E binding DNA binding, bending animal organ morphogenesis anterior/posterior pattern specification Wnt signaling pathway negative regulation of angiogenesis poly(A)+ mRNA export from nucleus interkinetic nuclear migration hemopoiesis cell differentiation positive regulation of Wnt signaling pathway B cell differentiation thyroid gland development forebrain development negative regulation of vascular endothelial growth factor receptor signaling pathway pancreas development protein-DNA complex protein localization to nucleus embryonic heart tube development multicellular organism growth regulation of cell proliferation protein homodimerization activity sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic organ development tissue morphogenesis forebrain morphogenesis primary lung bud formation common bile duct development gall bladder development hepatic duct development hepatoblast differentiation hepatocyte differentiation repressing transcription factor binding regulation of leukocyte proliferation DNA conformation change HMG box domain binding primitive streak formation uc008hio.1 uc008hio.2 uc008hio.3 
ENSMUST00000025946.7 Cyp26a1 ENSMUST00000025946.7 cytochrome P450, family 26, subfamily a, polypeptide 1 (from RefSeq NM_007811.2) A0A0R4J061 A0A0R4J061_MOUSE Cyp26a1 ENSMUST00000025946.1 ENSMUST00000025946.2 ENSMUST00000025946.3 ENSMUST00000025946.4 ENSMUST00000025946.5 ENSMUST00000025946.6 NM_007811 uc008his.1 uc008his.2 uc008his.3 uc008his.4 uc008his.5 Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51492, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134185; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51493; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane ; Peripheral membrane protein Membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. kidney development retinoic acid binding monooxygenase activity iron ion binding xenobiotic metabolic process retinoic acid 4-hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen heme binding response to retinoic acid response to vitamin A retinoic acid catabolic process retinoic acid metabolic process metal ion binding oxidation-reduction process uc008his.1 uc008his.2 uc008his.3 uc008his.4 uc008his.5 
ENSMUST00000025955.8 Eif3a ENSMUST00000025955.8 eukaryotic translation initiation factor 3, subunit A (from RefSeq NM_010123.3) Csma E9QQ50 EIF3A_MOUSE ENSMUST00000025955.1 ENSMUST00000025955.2 ENSMUST00000025955.3 ENSMUST00000025955.4 ENSMUST00000025955.5 ENSMUST00000025955.6 ENSMUST00000025955.7 Eif3 Eif3s10 NM_010123 P23116 Q60697 Q62162 uc008ibx.1 uc008ibx.2 uc008ibx.3 RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Interacts with KRT7 (By similarity). Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with EIF4G1 and PIWIL2. Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Note=Centrosomin-A is found in the centrosome. Centrosomin-B is found in the nucleus. Phosphorylated. Phosphorylation is enhanced upon serum stimulation. Modified_positions=Not_applicable; Note=Some positions are modified by RNA editing via nucleotide deletion, up to position 787. The unedited version gives rise to centrosomin-B (shown here). The fully edited version gives rise to centrosomin-A, in which the C- terminal sequence is replaced up to position 787 by Ser-Ile-Val-Ala- STOP. A combination of alternative splicing and RNA editing resulting in this template G deletion could also explain the generation of centrosomin-A mRNA. ; Belongs to the eIF-3 subunit A family. Sequence=CAA35246.1; Type=Frameshift; Evidence=; Sequence=CAA59144.1; Type=Frameshift; Evidence=; formation of cytoplasmic translation initiation complex cytoplasmic translational initiation translation reinitiation RNA binding mRNA binding translation initiation factor activity protein binding nucleus nucleolus cytoplasm microtubule organizing center cytosol eukaryotic translation initiation factor 3 complex cytoskeleton microtubule translation translational initiation postsynaptic density eukaryotic 43S preinitiation complex receptor tyrosine kinase binding eukaryotic 48S preinitiation complex multi-eIF complex negative regulation of ERK1 and ERK2 cascade eukaryotic translation initiation factor 3 complex, eIF3e eukaryotic translation initiation factor 3 complex, eIF3m IRES-dependent viral translational initiation viral translational termination-reinitiation uc008ibx.1 uc008ibx.2 uc008ibx.3 
ENSMUST00000025956.13 Pde6c ENSMUST00000025956.13 phosphodiesterase 6C, cGMP specific, cone, alpha prime, transcript variant 1 (from RefSeq NM_033614.3) ENSMUST00000025956.1 ENSMUST00000025956.10 ENSMUST00000025956.11 ENSMUST00000025956.12 ENSMUST00000025956.2 ENSMUST00000025956.3 ENSMUST00000025956.4 ENSMUST00000025956.5 ENSMUST00000025956.6 ENSMUST00000025956.7 ENSMUST00000025956.8 ENSMUST00000025956.9 NM_033614 PDE6C_MOUSE Q8R0D4 Q91ZQ1 uc008hjf.1 uc008hjf.2 uc008hjf.3 uc008hjf.4 uc008hjf.5 As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, ChEBI:CHEBI:58115; EC=3.1.4.35; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Composed of two alpha' subunits that are associated with 3 smaller proteins of 11, 13, and 15 kDa. Cell membrane ; Lipid-anchor ; Cytoplasmic side Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91ZQ1-1; Sequence=Displayed; Name=2; IsoId=Q91ZQ1-2; Sequence=VSP_017422; Belongs to the cyclic nucleotide phosphodiesterase family. nucleotide binding 3',5'-cyclic-nucleotide phosphodiesterase activity plasma membrane signal transduction visual perception phototransduction, visible light phosphoric diester hydrolase activity membrane hydrolase activity cGMP binding retinal cone cell development metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity response to stimulus sensory perception of light stimulus uc008hjf.1 uc008hjf.2 uc008hjf.3 uc008hjf.4 uc008hjf.5 
ENSMUST00000025957.9 Dennd10 ENSMUST00000025957.9 DENN domain containing 10, transcript variant 1 (from RefSeq NM_026437.5) DEN10_MOUSE Dennd10 ENSMUST00000025957.1 ENSMUST00000025957.2 ENSMUST00000025957.3 ENSMUST00000025957.4 ENSMUST00000025957.5 ENSMUST00000025957.6 ENSMUST00000025957.7 ENSMUST00000025957.8 Fam45a NM_026437 Q3UL11 Q91WS5 Q9D8N2 uc008ica.1 uc008ica.2 uc008ica.3 uc008ica.4 uc008ica.5 Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP- bound form. Interacts with RAB27A and RAB27B (GDP-bound forms preferentially). Late endosome Belongs to the DENND10 family. molecular_function guanyl-nucleotide exchange factor activity cellular_component cell late endosome biological_process protein transport small GTPase binding endosome transport via multivesicular body sorting pathway regulation of early endosome to late endosome transport uc008ica.1 uc008ica.2 uc008ica.3 uc008ica.4 uc008ica.5 
ENSMUST00000025961.7 Prdx3 ENSMUST00000025961.7 peroxiredoxin 3 (from RefSeq NM_007452.2) Aop1 ENSMUST00000025961.1 ENSMUST00000025961.2 ENSMUST00000025961.3 ENSMUST00000025961.4 ENSMUST00000025961.5 ENSMUST00000025961.6 Mer5 NM_007452 P20108 PRDX3_MOUSE uc008icd.1 uc008icd.2 uc008icd.3 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (By similarity). Required for the maintenance of physical strength (PubMed:27037278). Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]- disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.24; Evidence=; Homodimer; disulfide-linked, upon oxidation. 6 homodimers assemble to form a ring-like dodecamer. Interacts with NEK6. Interacts with LRRK2. Interacts with MAP3K13 (By similarity). Interacts with RPS6KC1 (via PX domain). Mitochondrion Cytoplasm Early endosome Note=Localizes to early endosomes in a RPS6KC1-dependent manner. Housekeeping-type gene preferentially expressed in murine erythroleukemia (MEL) cells. Expression is increased after induction of MEL cells to differentiation by DMSO. Phosphorylated by LRRK2; phosphorylation reduces perodixase activity. The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. S-palmitoylated. Accelerates decline of physical strength; at the age of 10 months, the physical strength is much lower than in the wild- type littermate (PubMed:27037278). Increased oxidative damage and decreased mitochondrial DNA copy number in skeletal muscles (PubMed:27037278). Increased apoptotic cells in the brain (PubMed:27037278). The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin. Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. maternal placenta development peroxidase activity cytoplasm mitochondrion endosome early endosome cytosol apoptotic process response to oxidative stress mitochondrion organization protein C-terminus binding positive regulation of cell proliferation thioredoxin peroxidase activity antioxidant activity oxidoreductase activity peptidyl-cysteine oxidation kinase binding protein kinase binding myeloid cell differentiation response to lipopolysaccharide macromolecular complex negative regulation of kinase activity cellular response to oxidative stress cellular response to reactive oxygen species response to hydrogen peroxide hydrogen peroxide catabolic process identical protein binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process myelin sheath negative regulation of neuron apoptotic process cell redox homeostasis positive regulation of NF-kappaB transcription factor activity regulation of mitochondrial membrane potential peroxiredoxin activity oxidation-reduction process cellular oxidant detoxification uc008icd.1 uc008icd.2 uc008icd.3 
ENSMUST00000025963.8 Noc3l ENSMUST00000025963.8 NOC3 like DNA replication regulator (from RefSeq NM_021315.2) Ad24 E9QQ46 ENSMUST00000025963.1 ENSMUST00000025963.2 ENSMUST00000025963.3 ENSMUST00000025963.4 ENSMUST00000025963.5 ENSMUST00000025963.6 ENSMUST00000025963.7 Fad24 NM_021315 NOC3L_MOUSE Q8VI84 Q9JKM3 uc008hjr.1 uc008hjr.2 uc008hjr.3 May be required for adipogenesis. Nucleus, nucleolus Nucleus speckle Induced between 1 and 12 hours following adipogenic stimulus. Belongs to the CBF/MAK21 family. chromatin binding nucleus nucleolus mitochondrion nuclear speck fat cell differentiation uc008hjr.1 uc008hjr.2 uc008hjr.3 
ENSMUST00000025965.12 Hells ENSMUST00000025965.12 helicase, lymphoid specific (from RefSeq NM_008234.3) ENSMUST00000025965.1 ENSMUST00000025965.10 ENSMUST00000025965.11 ENSMUST00000025965.2 ENSMUST00000025965.3 ENSMUST00000025965.4 ENSMUST00000025965.5 ENSMUST00000025965.6 ENSMUST00000025965.7 ENSMUST00000025965.8 ENSMUST00000025965.9 HELLS_MOUSE Hells Lsh NM_008234 Pasg Q497T3 Q60848 Q8VDZ1 Q9CYV7 uc008hjt.1 uc008hjt.2 uc008hjt.3 Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis. Q60848; P25916: Bmi1; NbExp=2; IntAct=EBI-3043887, EBI-927401; Q60848; P30658: Cbx2; NbExp=2; IntAct=EBI-3043887, EBI-360174; Q60848; O88508: Dnmt3a; NbExp=4; IntAct=EBI-3043887, EBI-995154; Q60848; O88509: Dnmt3b; NbExp=4; IntAct=EBI-3043887, EBI-7987547; Q60848; P23798: Pcgf2; NbExp=2; IntAct=EBI-3043887, EBI-926857; Nucleus te=Closely associated with pericentric heterochromatin. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q60848-1; Sequence=Displayed; Name=2 ; IsoId=Q60848-2; Sequence=VSP_052235; Highly expressed in thymus, bone marrow, and testis. Not detected in heart, brain, liver, kidney, skeletal muscle, spleen, peripheral blood lymphocytes, small intestine, colon, prostate or ovary. Differentially expressed during embryonic development, with highest expression in developing face, limbs, skeletal muscle, heart, and tail. Highly expressed in fetal thymocytes from day 14 to 16 of gestation, and expressed at much lower levels in adult thymus. By concanavalin or lipopolysaccharide in unactivated splenocytes. Belongs to the SNF2/RAD54 helicase family. Sequence=AAH20056.1; Type=Erroneous initiation; Evidence=; nucleotide binding chromosome, centromeric region urogenital system development chromatin binding helicase activity protein binding ATP binding nucleus pericentric heterochromatin DNA methylation chromatin silencing methylation-dependent chromatin silencing cell cycle multicellular organism development maintenance of DNA methylation hydrolase activity lymphocyte differentiation pericentric heterochromatin assembly negative regulation of apoptotic process lymphocyte proliferation cell division cellular response to leukemia inhibitory factor negative regulation of intrinsic apoptotic signaling pathway uc008hjt.1 uc008hjt.2 uc008hjt.3 
ENSMUST00000025966.5 Cyp2c55 ENSMUST00000025966.5 cytochrome P450, family 2, subfamily c, polypeptide 55 (from RefSeq NM_028089.3) CP255_MOUSE Cyp2c-55 Cyp2c55 ENSMUST00000025966.1 ENSMUST00000025966.2 ENSMUST00000025966.3 ENSMUST00000025966.4 NM_028089 Q9D816 uc008hju.1 uc008hju.2 uc008hju.3 Metabolizes arachidonic acid mainly to 19- hydroxyeicosatetraenoic acid (HETE). Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Highest level in colon. Low levels in liver and small intestine. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity retinoic acid 4-hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen arachidonic acid metabolic process epoxygenase P450 pathway heme binding organelle membrane retinoic acid metabolic process exogenous drug catabolic process intracellular membrane-bounded organelle linoleic acid metabolic process metal ion binding oxidation-reduction process aromatase activity linoleic acid epoxygenase activity uc008hju.1 uc008hju.2 uc008hju.3 
ENSMUST00000025968.5 Cyp2c39 ENSMUST00000025968.5 cytochrome P450, family 2, subfamily c, polypeptide 39, transcript variant 1 (from RefSeq NM_010003.2) B9EIA6 CP239_MOUSE Cyp2c39 ENSMUST00000025968.1 ENSMUST00000025968.2 ENSMUST00000025968.3 ENSMUST00000025968.4 G5E854 NM_010003 P56656 uc008hkb.1 uc008hkb.2 uc008hkb.3 uc008hkb.4 A cytochrome P450 monooxygenase that primarily catalyzes the epoxidation of 11,12 and 14,15 double bonds of (5Z,8Z,11Z,14Z)- eicosatetraenoic acid (arachidonate) forming 11,12- and 14,15- epoxyeicosatrienoic acids (11,12- and 14,15-EET) regioisomers. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-- hemoprotein reductase). Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51480, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76625; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51481; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51472, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:84024; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51473; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Lipid metabolism; arachidonate metabolism. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Liver. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity retinoic acid 4-hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding organelle membrane caffeine oxidase activity exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity estrogen 16-alpha-hydroxylase activity uc008hkb.1 uc008hkb.2 uc008hkb.3 uc008hkb.4 
ENSMUST00000025979.13 Aldh18a1 ENSMUST00000025979.13 aldehyde dehydrogenase 18 family, member A1, transcript variant 1 (from RefSeq NM_019698.2) ENSMUST00000025979.1 ENSMUST00000025979.10 ENSMUST00000025979.11 ENSMUST00000025979.12 ENSMUST00000025979.2 ENSMUST00000025979.3 ENSMUST00000025979.4 ENSMUST00000025979.5 ENSMUST00000025979.6 ENSMUST00000025979.7 ENSMUST00000025979.8 ENSMUST00000025979.9 NM_019698 P5CS_MOUSE P5cs Pycs Q8BGM2 Q9R1P6 Q9Z110 uc008hkx.1 uc008hkx.2 uc008hkx.3 Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. Reaction=ATP + L-glutamate = ADP + L-glutamyl 5-phosphate; Xref=Rhea:RHEA:14877, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:58274, ChEBI:CHEBI:456216; EC=2.7.2.11; Evidence=; Reaction=L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L- glutamyl 5-phosphate + NADPH; Xref=Rhea:RHEA:19541, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:58066, ChEBI:CHEBI:58274, ChEBI:CHEBI:58349; EC=1.2.1.41; Evidence=; Isoform Short: Inhibited by L-ornithine with a Ki of approximately 0.25 mm. Isoform Long: Insensitive to ornithine inhibition. Thus, the two amino acid insert in the long isoform abolishes feedback inhibition of P5CS activity by L-ornithine. Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. Homohexamer or homotetramer. Mitochondrion inner membrane Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q9Z110-1; Sequence=Displayed; Name=Short; IsoId=Q9Z110-2; Sequence=VSP_005216; In the N-terminal section; belongs to the glutamate 5- kinase family. In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. nucleotide binding catalytic activity glutamate 5-kinase activity glutamate-5-semialdehyde dehydrogenase activity ATP binding cytoplasm mitochondrion mitochondrial inner membrane cytosol glutamate metabolic process proline biosynthetic process ornithine biosynthetic process metabolic process cellular amino acid biosynthetic process response to temperature stimulus membrane kinase activity phosphorylation oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor transferase activity citrulline biosynthetic process mitochondrial membrane identical protein binding oxidation-reduction process L-proline biosynthetic process uc008hkx.1 uc008hkx.2 uc008hkx.3 
ENSMUST00000025983.13 Ccnj ENSMUST00000025983.13 cyclin J (from RefSeq NM_172839.4) CCNJ_MOUSE ENSMUST00000025983.1 ENSMUST00000025983.10 ENSMUST00000025983.11 ENSMUST00000025983.12 ENSMUST00000025983.2 ENSMUST00000025983.3 ENSMUST00000025983.4 ENSMUST00000025983.5 ENSMUST00000025983.6 ENSMUST00000025983.7 ENSMUST00000025983.8 ENSMUST00000025983.9 NM_172839 Q1ED41 Q3TZI6 Q8BIY5 uc012blp.1 uc012blp.2 uc012blp.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TZI6-1; Sequence=Displayed; Name=2; IsoId=Q3TZI6-2; Sequence=VSP_029129; Belongs to the cyclin family. Cyclin J subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein kinase holoenzyme complex nucleus cytoplasm protein phosphorylation cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding mitotic cell cycle phase transition protein kinase activity uc012blp.1 uc012blp.2 uc012blp.3 
ENSMUST00000025986.15 Tll2 ENSMUST00000025986.15 tolloid-like 2 (from RefSeq NM_011904.4) A2RTK3 ENSMUST00000025986.1 ENSMUST00000025986.10 ENSMUST00000025986.11 ENSMUST00000025986.12 ENSMUST00000025986.13 ENSMUST00000025986.14 ENSMUST00000025986.2 ENSMUST00000025986.3 ENSMUST00000025986.4 ENSMUST00000025986.5 ENSMUST00000025986.6 ENSMUST00000025986.7 ENSMUST00000025986.8 ENSMUST00000025986.9 NM_011904 Q9WVM6 TLL2_MOUSE uc008hlr.1 uc008hlr.2 uc008hlr.3 Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. Secreted Expressed at 7.5 dpc, in a limited way, in the posterior portion of the egg cylinder in the nascent mesoderm streaming off the primitive streak. At the distant end of the embryo cylinder, expression ended at the node. Later in the development, expression seems to be limited to developing skeletal muscle and central nervous system. metalloendopeptidase activity calcium ion binding extracellular region proteolysis multicellular organism development peptidase activity metallopeptidase activity zinc ion binding hydrolase activity cell differentiation metal ion binding negative regulation of skeletal muscle tissue growth uc008hlr.1 uc008hlr.2 uc008hlr.3 
ENSMUST00000025993.10 Slit1 ENSMUST00000025993.10 slit guidance ligand 1 (from RefSeq NM_015748.3) ENSMUST00000025993.1 ENSMUST00000025993.2 ENSMUST00000025993.3 ENSMUST00000025993.4 ENSMUST00000025993.5 ENSMUST00000025993.6 ENSMUST00000025993.7 ENSMUST00000025993.8 ENSMUST00000025993.9 Kiaa0813 NM_015748 Q80TR4 Q9WVB5 SLIT1_MOUSE uc008hmf.1 uc008hmf.2 uc008hmf.3 uc008hmf.4 Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Interacts with GREM1 (By similarity) and ROBO1. Secreted During retinal development, is expressed at 12.5 dpc in the dorsocentral region of the retina, and at 17.5 dpc is only very weakly expressed. In the developing optic chiasm is expressed at 12.5 dpc around the junction of the optic nerve and the brain, with strongest expression dorsal to the site at which the optic stalk joins the diencephalon, and also weakly in a subset of the CD44/SSEA neurons. In the more dorsal region of the developing optic chiasm, is expressed in some distance posterior to the axons. However, more ventrally, is expressed in a region directly adjacent to the path taken by the RGC axons. By 17.5 dpc is not longer be detected at the junction of the brain and optic nerve and is only weakly expressed by the CD44/SSEA neurons. Outside the developing brain detected at between 8.5 dpc and 9.5 dpc in the primordiun of the branchial arches, between 9.5 dpc and 10.5 dpc in the posterior dermamyotome. By 11.5 dpc the expression pattern along somite boundaries was most prominent caudally. Weak expression was also observed in the nasal pit at 11.5 dpc. From 13.5 dpc to 17.5 dpc expression was observed in the trigeminal ganglion, in the olfactory epithelium, and in the neural layer of the retina in the developing eye (with strongest expression in the inner nuclear layer). Mice show significant axon guidance errors in a variety of pathways, including corticofugal, callosal and thalamocortical tracts. Mice double-deficient in SLIT1 and SLIT2 show retinal axon guidance defects and a disorganized lateral olfactory tract (LOT). Sequence=BAC65658.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; receptor binding calcium ion binding extracellular region extracellular space plasma membrane nuclear migration multicellular organism development nervous system development axonogenesis axon guidance motor neuron axon guidance heparin binding olfactory bulb development tangential migration from the subventricular zone to the olfactory bulb telencephalon cell migration cell differentiation retinal ganglion cell axon guidance dorsal/ventral axon guidance heparan sulfate proteoglycan binding Roundabout binding neuron projection morphogenesis negative regulation of axon extension involved in axon guidance axon extension involved in axon guidance negative chemotaxis negative regulation of synapse assembly uc008hmf.1 uc008hmf.2 uc008hmf.3 uc008hmf.4 
ENSMUST00000025997.7 Smndc1 ENSMUST00000025997.7 survival motor neuron domain containing 1, transcript variant 1 (from RefSeq NM_172429.3) ENSMUST00000025997.1 ENSMUST00000025997.2 ENSMUST00000025997.3 ENSMUST00000025997.4 ENSMUST00000025997.5 ENSMUST00000025997.6 NM_172429 Q4QQL0 Q8BGT7 SPF30_MOUSE Smnr Spf30 uc008hwt.1 uc008hwt.2 uc008hwt.3 Involved in spliceosome assembly (By similarity). Associates with spliceosomes. Associates with U4/U5/U6 tri- snRNP and with U2 snRNP (By similarity). Nucleus speckle Nucleus, Cajal body Note=Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies. The Tudor domain mediates association with dimethylarginines, which are common in snRNP proteins. Belongs to the SMN family. RNA binding nucleus spliceosomal complex cytoplasm mRNA processing apoptotic process RNA splicing Cajal body nuclear speck uc008hwt.1 uc008hwt.2 uc008hwt.3 
ENSMUST00000026008.9 Trim8 ENSMUST00000026008.9 tripartite motif-containing 8, transcript variant 1 (from RefSeq NM_053100.2) ENSMUST00000026008.1 ENSMUST00000026008.2 ENSMUST00000026008.3 ENSMUST00000026008.4 ENSMUST00000026008.5 ENSMUST00000026008.6 ENSMUST00000026008.7 ENSMUST00000026008.8 Gerp NM_053100 Q3U2G3 Q8C508 Q8C700 Q8CGI2 Q99PJ2 Q99PQ4 Rnf27 TRIM8_MOUSE uc008hts.1 uc008hts.2 uc008hts.3 uc008hts.4 E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response (PubMed:28747347, PubMed:31360105). Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (By similarity). Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (By similarity). Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction (PubMed:28747347). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Homodimer. Interacts with SOCS1 (via) SH2 domain and SOCS box. Interacts with HSP90AB1; prevents nucleus translocation of phosphorylated STAT3 and HSP90AB1 (PubMed:21689689). Interacts with MAP3K7/TAK1 (By similarity). Interacts with PIAS3 (By similarity). Interacts with TICAM1 (PubMed:28747347). Interacts with TRIM15; this interaction prevents TRIM8 cytoplasmic translocation (By similarity). High expression in heart, liver, and thymus. Expressed in embryonic CNS, kidney, lens and gut. At 10.5 and 12.5 dpc, expressed in the central nervous system. At 14.5 dpc, expressed in the eye (lens and inner neural layer of the retina), in the primitive glomeruli of the developing kidney, in the villi of the gut and in the dorsal root ganglia. The coiled coil domain is required for homodimerization. The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1. Mice are more susceptible to LPS and bacterial- induced death (PubMed:28747347). In addition, TRIM8 deletion plays a protective role in hepatocyte injury triggered by hepatic ischaemia/reperfusion (I/R) injury (PubMed:31360105). Belongs to the TRIM/RBCC family. immune system process ubiquitin-protein transferase activity protein binding nucleus cytosol positive regulation of autophagy protein ubiquitination PML body transferase activity stem cell population maintenance negative regulation of viral transcription identical protein binding protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response negative regulation of viral entry into host cell metal ion binding positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of protein localization to nucleus negative regulation of viral release from host cell uc008hts.1 uc008hts.2 uc008hts.3 uc008hts.4 
ENSMUST00000026009.10 Arl3 ENSMUST00000026009.10 ADP-ribosylation factor-like 3, transcript variant 1 (from RefSeq NM_019718.3) ARL3_MOUSE Arl3 ENSMUST00000026009.1 ENSMUST00000026009.2 ENSMUST00000026009.3 ENSMUST00000026009.4 ENSMUST00000026009.5 ENSMUST00000026009.6 ENSMUST00000026009.7 ENSMUST00000026009.8 ENSMUST00000026009.9 NM_019718 Q9WUL7 uc008htt.1 uc008htt.2 uc008htt.3 Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP) (PubMed:18376416). Required for normal cytokinesis and cilia signaling. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms (PubMed:15979089). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (PubMed:25405894). Found in a complex with ARL3, RP2 and UNC119 (or UNC119B); RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119 (or UNC119B). Interacts with RP2; interaction is direct and stimulated with the activated GTP-bound form of ARL3. Interacts with SYS1. Interacts with ARL2BP; the GTP-bound form interacts with ARL2BP. Microtubule-associated protein. Does not interact with TBCC (By similarity). Interacts with RP2 (PubMed:18376416). Interacts with PDE6D; the interaction occurs specifically with the GTP-bound form of ARL3 (PubMed:10518933, PubMed:15979089). Interacts with GGA1; the interaction recruits PKD1:PKD2 complex to trans-Golgi network and is required for ciliary targeting of PKD1:PKD2 complex (PubMed:25405894). Interacts with DNAAF9 (By similarity). Q9WUL7; Q8C6E0: Cfap36; NbExp=5; IntAct=EBI-6860857, EBI-16180842; Q9WUL7; Q96G28: CFAP36; Xeno; NbExp=2; IntAct=EBI-6860857, EBI-2654750; Q9WUL7; O43924: PDE6D; Xeno; NbExp=4; IntAct=EBI-6860857, EBI-712685; Q9WUL7; O75695: RP2; Xeno; NbExp=5; IntAct=EBI-6860857, EBI-7996807; Q9WUL7; Q13432: UNC119; Xeno; NbExp=3; IntAct=EBI-6860857, EBI-711260; Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm Cell projection, cilium Note=Detected predominantly in the photoreceptor connecting cilium. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules (By similarity). Present on the mitotic spindle. Lethality by 3 weeks of age. Mice exhibit abnormal development of renal, hepatic, and pancreatic epithelial tubule structures. Mice show abnormal epithelial cell proliferation and cyst formation. Moreover, they exhibit photoreceptor degeneration as early as postnatal day 14. Belongs to the small GTPase superfamily. Arf family. Golgi membrane nucleotide binding mitotic cytokinesis magnesium ion binding kidney development GTPase activity protein binding GTP binding nucleus cytoplasm Golgi apparatus centrosome microtubule organizing center spindle cytoskeleton spindle microtubule cytoplasmic microtubule cilium axoneme post-Golgi vesicle-mediated transport Golgi to plasma membrane transport cell cycle smoothened signaling pathway small GTPase mediated signal transduction microtubule binding protein transport microtubule cytoskeleton membrane GDP binding midbody photoreceptor connecting cilium GTPase activating protein binding ciliary transition zone ciliary basal body intraciliary transport photoreceptor cell development cell projection metal ion binding cell division cilium assembly protein localization to cilium protein localization to ciliary membrane uc008htt.1 uc008htt.2 uc008htt.3 
ENSMUST00000026011.8 Sfxn2 ENSMUST00000026011.8 sideroflexin 2 (from RefSeq NM_053196.3) ENSMUST00000026011.1 ENSMUST00000026011.2 ENSMUST00000026011.3 ENSMUST00000026011.4 ENSMUST00000026011.5 ENSMUST00000026011.6 ENSMUST00000026011.7 NM_053196 Q925N2 SFXN2_MOUSE Sfxn2 uc008htu.1 uc008htu.2 uc008htu.3 uc008htu.4 uc008htu.5 Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria (By similarity). Involved in mitochondrial iron homeostasis by regulating heme biosynthesis (By similarity). Reaction=L-serine(in) = L-serine(out); Xref=Rhea:RHEA:35031, ChEBI:CHEBI:33384; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Mitochondrion outer membrane ; Multi-pass membrane protein Expressed in brain, heart, kidney, spleen, thymus, liver, stomach and skin. Belongs to the sideroflexin family. molecular_function mitochondrion mitochondrial inner membrane ion transport amino acid transport ion transmembrane transporter activity membrane integral component of membrane mitochondrial membrane ion transmembrane transport transmembrane transport mitochondrial transmembrane transport uc008htu.1 uc008htu.2 uc008htu.3 uc008htu.4 uc008htu.5 
ENSMUST00000026012.8 Cyp17a1 ENSMUST00000026012.8 cytochrome P450, family 17, subfamily a, polypeptide 1 (from RefSeq NM_007809.3) Cyp17 Cyp17a1 ENSMUST00000026012.1 ENSMUST00000026012.2 ENSMUST00000026012.3 ENSMUST00000026012.4 ENSMUST00000026012.5 ENSMUST00000026012.6 ENSMUST00000026012.7 NM_007809 Q53YJ1 Q53YJ1_MOUSE uc008hua.1 uc008hua.2 uc008hua.3 uc008hua.4 Belongs to the cytochrome P450 family. monooxygenase activity steroid 17-alpha-monooxygenase activity iron ion binding steroid metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen lyase activity heme binding hormone biosynthetic process progesterone metabolic process metal ion binding 17-alpha-hydroxyprogesterone aldolase activity oxidation-reduction process uc008hua.1 uc008hua.2 uc008hua.3 uc008hua.4 
ENSMUST00000026013.6 Maoa ENSMUST00000026013.6 monoamine oxidase A (from RefSeq NM_173740.3) AOFA_MOUSE B1AX52 ENSMUST00000026013.1 ENSMUST00000026013.2 ENSMUST00000026013.3 ENSMUST00000026013.4 ENSMUST00000026013.5 Maoa NM_173740 Q64133 Q8K0Z8 uc009ssa.1 uc009ssa.2 uc009ssa.3 uc009ssa.4 Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:7792602). Preferentially oxidizes serotonin (PubMed:7792602). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity). Reaction=a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2; Xref=Rhea:RHEA:26414, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478, ChEBI:CHEBI:58855, ChEBI:CHEBI:65296; EC=1.4.3.4; Evidence=; Reaction=an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:16153, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478, ChEBI:CHEBI:28938, ChEBI:CHEBI:58001; EC=1.4.3.21; Evidence=; Reaction=H2O + O2 + serotonin = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:69072, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:50157, ChEBI:CHEBI:350546; Evidence=; Reaction=(R)-adrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine; Xref=Rhea:RHEA:51168, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:59338, ChEBI:CHEBI:71406, ChEBI:CHEBI:180943; Evidence=; Reaction=dopamine + H2O + O2 = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:27946, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:27978, ChEBI:CHEBI:28938, ChEBI:CHEBI:59905; Evidence=; Reaction=H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:30591, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:15621, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:327995; Evidence=; Reaction=(R)-noradrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:69076, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:72587, ChEBI:CHEBI:180943; Evidence=; Reaction=H2O + kynuramine + O2 = 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+); Xref=Rhea:RHEA:59596, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:180898, ChEBI:CHEBI:180899; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59597; Evidence=; Reaction=H2O + O2 + tryptamine = H2O2 + indole-3-acetaldehyde + NH4(+); Xref=Rhea:RHEA:59416, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18086, ChEBI:CHEBI:28938, ChEBI:CHEBI:57887; Evidence=; Reaction=2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:25265, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:16424, ChEBI:CHEBI:28938, ChEBI:CHEBI:225237; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity). Mitochondrion outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side Belongs to the flavin monoamine oxidase family. protein binding mitochondrion mitochondrial outer membrane catecholamine metabolic process primary amine oxidase activity positive regulation of signal transduction membrane integral component of membrane oxidoreductase activity neurotransmitter catabolic process dopamine catabolic process serotonin metabolic process phenylethylamine metabolic process flavin adenine dinucleotide binding serotonin binding oxidation-reduction process uc009ssa.1 uc009ssa.2 uc009ssa.3 uc009ssa.4 
ENSMUST00000026014.8 Efhc2 ENSMUST00000026014.8 EF-hand domain (C-terminal) containing 2 (from RefSeq NM_028916.5) EFHC2_MOUSE ENSMUST00000026014.1 ENSMUST00000026014.2 ENSMUST00000026014.3 ENSMUST00000026014.4 ENSMUST00000026014.5 ENSMUST00000026014.6 ENSMUST00000026014.7 NM_028916 Q0VBF5 Q8CDV9 Q9D485 uc009sse.1 uc009sse.2 uc009sse.3 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Cytoplasm, cytoskeleton, cilium axoneme molecular_function regulation of neuron projection development cellular response to leukemia inhibitory factor microtubule uc009sse.1 uc009sse.2 uc009sse.3 
ENSMUST00000026016.13 Fundc1 ENSMUST00000026016.13 FUN14 domain containing 1, transcript variant 1 (from RefSeq NM_028058.4) A2BEA3 ENSMUST00000026016.1 ENSMUST00000026016.10 ENSMUST00000026016.11 ENSMUST00000026016.12 ENSMUST00000026016.2 ENSMUST00000026016.3 ENSMUST00000026016.4 ENSMUST00000026016.5 ENSMUST00000026016.6 ENSMUST00000026016.7 ENSMUST00000026016.8 ENSMUST00000026016.9 FUND1_MOUSE NM_028058 Q9DB70 uc009ssg.1 uc009ssg.2 uc009ssg.3 uc009ssg.4 Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. Interacts (via YXXL motif) with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP. Q9DB70; O70405: Ulk1; NbExp=2; IntAct=EBI-10106464, EBI-8390771; Mitochondrion outer membrane ; Multi-pass membrane protein The YXXL motif mediates the interaction with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP. Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy (By similarity). Belongs to the FUN14 family. mitophagy response to hypoxia protein binding mitochondrion mitochondrial outer membrane autophagy response to organonitrogen compound membrane integral component of membrane integral component of mitochondrial outer membrane uc009ssg.1 uc009ssg.2 uc009ssg.3 uc009ssg.4 
ENSMUST00000026018.4 Dusp21 ENSMUST00000026018.4 dual specificity phosphatase 21 (from RefSeq NM_028568.1) DUS21_MOUSE ENSMUST00000026018.1 ENSMUST00000026018.2 ENSMUST00000026018.3 NM_028568 Q9D9D8 uc009ssi.1 uc009ssi.2 uc009ssi.3 uc009ssi.4 Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Cytoplasm Nucleus Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Selectively expressed in testis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. inactivation of MAPK activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm mitochondrion mitochondrial inner membrane mitochondrial intermembrane space mitochondrial matrix protein dephosphorylation protein targeting to membrane protein targeting to mitochondrion protein tyrosine/serine/threonine phosphatase activity membrane dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity extrinsic component of membrane extrinsic component of mitochondrial inner membrane protein localization to organelle peptidyl-tyrosine dephosphorylation uc009ssi.1 uc009ssi.2 uc009ssi.3 uc009ssi.4 
ENSMUST00000026021.14 Msr1 ENSMUST00000026021.14 macrophage scavenger receptor 1, transcript variant 2 (from RefSeq NM_001113326.2) E9QNQ5 ENSMUST00000026021.1 ENSMUST00000026021.10 ENSMUST00000026021.11 ENSMUST00000026021.12 ENSMUST00000026021.13 ENSMUST00000026021.2 ENSMUST00000026021.3 ENSMUST00000026021.4 ENSMUST00000026021.5 ENSMUST00000026021.6 ENSMUST00000026021.7 ENSMUST00000026021.8 ENSMUST00000026021.9 MSRE_MOUSE NM_001113326 P30204 Q923G0 Q9QZ56 Scvr uc012gcm.1 uc012gcm.2 uc012gcm.3 Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Homotrimer (PubMed:8394868). Interacts with MYO18A (By similarity). Membrane; Single-pass type II membrane protein. Event=Alternative splicing; Named isoforms=2; Name=I; IsoId=P30204-1; Sequence=Displayed; Name=II; IsoId=P30204-2; Sequence=VSP_006231, VSP_006232; Sequence=AAA39747.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAA39748.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; beta-amyloid binding scavenger receptor activity collagen trimer cytosol plasma membrane endocytosis receptor-mediated endocytosis phagocytosis, engulfment negative regulation of gene expression positive regulation of macrophage derived foam cell differentiation positive regulation of cholesterol storage membrane integral component of membrane low-density lipoprotein particle binding cholesterol transport cytoplasmic vesicle low-density lipoprotein particle plasma lipoprotein particle clearance cargo receptor activity lipoprotein transport beta-amyloid clearance uc012gcm.1 uc012gcm.2 uc012gcm.3 
ENSMUST00000026027.7 Taf5 ENSMUST00000026027.7 TATA-box binding protein associated factor 5 (from RefSeq NM_177342.3) ENSMUST00000026027.1 ENSMUST00000026027.2 ENSMUST00000026027.3 ENSMUST00000026027.4 ENSMUST00000026027.5 ENSMUST00000026027.6 F8VPY2 F8VPY2_MOUSE NM_177342 Taf5 uc008hun.1 uc008hun.2 uc008hun.3 Belongs to the WD repeat TAF5 family. nuclear chromatin transcription factor activity, sequence-specific DNA binding histone acetyltransferase activity nucleus nucleoplasm transcription factor TFIID complex DNA-templated transcription, initiation regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter actin cytoskeleton obsolete general RNA polymerase II transcription factor activity histone acetylation transcription factor TFTC complex identical protein binding transcription regulatory region DNA binding protein dimerization activity uc008hun.1 uc008hun.2 uc008hun.3 
ENSMUST00000026029.2 Samt4 ENSMUST00000026029.2 spermatogenesis associated multipass transmembrane protein 4 (from RefSeq NM_029199.3) 4930542N07Rik ENSMUST00000026029.1 NM_029199 Q9D4X6 Q9D4X6_MOUSE Samt4 uc009urh.1 uc009urh.2 Cell junction, tight junction Belongs to the claudin family. molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc009urh.1 uc009urh.2 
ENSMUST00000026032.7 Pcgf6 ENSMUST00000026032.7 polycomb group ring finger 6, transcript variant 1 (from RefSeq NM_027654.3) ENSMUST00000026032.1 ENSMUST00000026032.2 ENSMUST00000026032.3 ENSMUST00000026032.4 ENSMUST00000026032.5 ENSMUST00000026032.6 Mblr NM_027654 PCGF6_MOUSE Q99NA9 Rnf134 uc008hul.1 uc008hul.2 uc008hul.3 uc008hul.4 uc008hul.5 Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Component of a PRC1-like complex. Interacts with BMI1/PCGF4, RING1 and RNF2. Interacts with KDM5D. Interacts with CBX4, CBX6, CBX7 and CBX8. Nucleus Expressed in ovary, testis, stomach, liver, thymus and kidney (at protein level). Expressed in embryo at 10.5 dpc. Phosphorylated during mitosis. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus protein domain specific binding PcG protein complex PRC1 complex histone H2A-K119 monoubiquitination negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding inactivation of X chromosome by genetic imprinting uc008hul.1 uc008hul.2 uc008hul.3 uc008hul.4 uc008hul.5 
ENSMUST00000026036.5 Nr0b1 ENSMUST00000026036.5 nuclear receptor subfamily 0, group B, member 1 (from RefSeq NM_007430.5) Ahch Dax1 ENSMUST00000026036.1 ENSMUST00000026036.2 ENSMUST00000026036.3 ENSMUST00000026036.4 NM_007430 NR0B1_MOUSE O09068 O09147 Q61066 uc009tsd.1 uc009tsd.2 uc009tsd.3 uc009tsd.4 uc009tsd.5 This gene encodes an orphan nuclear receptor protein that plays a key role in differentiation of the gonads. This protein regulates steroidogenic factor 1 (Sf-1) in a dose-dependent manner, sometimes functioning as a repressor of SF-1 target genes, and sometimes functioning as a co-activator. Overexpression of this gene can cause feminization of the XY male gonads. This gene is also involved in the maintenance of embryonic stem cell pluripotancy. Mutations in the related gene in human cause congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, May 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U41568.1, AK141239.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2 (By similarity). Interacts with ESRRB; represses ESRRB activity at the GATA6 promoter (PubMed:27601327). Q61066; Q61539: Esrrb; NbExp=3; IntAct=EBI-2312665, EBI-2312731; Q61066; Q80Z64: Nanog; NbExp=7; IntAct=EBI-2312665, EBI-2312517; Q61066; P20263: Pou5f1; NbExp=5; IntAct=EBI-2312665, EBI-1606219; Q61066; Q6PR54: Rif1; NbExp=2; IntAct=EBI-2312665, EBI-2312621; Q61066; P70414: Slc8a1; NbExp=2; IntAct=EBI-2312665, EBI-2312694; Nucleus Cytoplasm Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus (By similarity). Expressed in adult cerebral cortex, spinal cord, thymus, heart, lung, ovary, testis, adrenal gland, hypothalamus, spleen and kidney. Expressed at 5.5 dpc throughout the embryo except in the proximal visceral endoderm. Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with NR5A1 and NROB2 through its N-terminal LXXLL motifs (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. negative regulation of transcription from RNA polymerase II promoter DNA binding double-stranded DNA binding steroid hormone receptor activity transcription corepressor activity RNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus cytoplasm microtubule organizing center regulation of transcription, DNA-templated steroid biosynthetic process spermatogenesis sex determination protein localization transcription factor binding gonad development male gonad development membrane nuclear speck protein domain specific binding cell differentiation male sex determination adrenal gland development intracellular receptor signaling pathway DNA hairpin binding negative regulation of intracellular steroid hormone receptor signaling pathway Leydig cell differentiation steroid hormone receptor binding response to immobilization stress polysomal ribosome protein homodimerization activity intracellular membrane-bounded organelle steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated AF-2 domain binding Sertoli cell differentiation sequence-specific DNA binding uc009tsd.1 uc009tsd.2 uc009tsd.3 uc009tsd.4 uc009tsd.5 
ENSMUST00000026050.8 Gsto1 ENSMUST00000026050.8 glutathione S-transferase omega 1 (from RefSeq NM_010362.3) ENSMUST00000026050.1 ENSMUST00000026050.2 ENSMUST00000026050.3 ENSMUST00000026050.4 ENSMUST00000026050.5 ENSMUST00000026050.6 ENSMUST00000026050.7 GSTO1_MOUSE Gstx Gtsttl NM_010362 O09131 Q3TH87 uc008hvq.1 uc008hvq.2 uc008hvq.3 uc008hvq.4 uc008hvq.5 This gene encodes a member of the omega class of glutathione S-transferase (GST) proteins. GSTs are involved in the metabolism of xenobiotics and carcinogens. There is evidence that the encoded protein is involved in the biotransformation of arsenic. [provided by RefSeq, Dec 2015]. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U80819.1, AK146834.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Reaction=2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate; Xref=Rhea:RHEA:24424, ChEBI:CHEBI:38290, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:58539; EC=1.8.5.1; Evidence=; Reaction=2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid; Xref=Rhea:RHEA:15969, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17826, ChEBI:CHEBI:33409, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.20.4.2; Evidence=; Homodimer. Cytoplasm, cytosol Belongs to the GST superfamily. Omega family. glutathione transferase activity basement membrane cytoplasm cytosol regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum oxidoreductase activity transferase activity L-ascorbic acid metabolic process L-ascorbic acid biosynthetic process axon nuclear membrane xenobiotic catabolic process myelin sheath cell body glutathione dehydrogenase (ascorbate) activity methylarsonate reductase activity oxidation-reduction process negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity cellular response to arsenic-containing substance cellular oxidant detoxification uc008hvq.1 uc008hvq.2 uc008hvq.3 uc008hvq.4 uc008hvq.5 
ENSMUST00000026062.10 Casp7 ENSMUST00000026062.10 caspase 7 (from RefSeq NM_007611.3) Casp7 ENSMUST00000026062.1 ENSMUST00000026062.2 ENSMUST00000026062.3 ENSMUST00000026062.4 ENSMUST00000026062.5 ENSMUST00000026062.6 ENSMUST00000026062.7 ENSMUST00000026062.8 ENSMUST00000026062.9 NM_007611 Q4FJQ4 Q4FJQ4_MOUSE uc008hyw.1 uc008hyw.2 uc008hyw.3 Belongs to the peptidase C14A family. cysteine-type endopeptidase activity cytosol proteolysis aging peptidase activity cysteine-type peptidase activity hydrolase activity intracellular membrane-bounded organelle striated muscle cell differentiation leukocyte apoptotic process uc008hyw.1 uc008hyw.2 uc008hyw.3 
ENSMUST00000026068.8 Vwa2 ENSMUST00000026068.8 von Willebrand factor A domain containing 2 (from RefSeq NM_172840.2) Amaco ENSMUST00000026068.1 ENSMUST00000026068.2 ENSMUST00000026068.3 ENSMUST00000026068.4 ENSMUST00000026068.5 ENSMUST00000026068.6 ENSMUST00000026068.7 NM_172840 Q14AY2 Q14BI0 Q3UM88 Q70UZ7 VWA2_MOUSE uc008hzl.1 uc008hzl.2 uc008hzl.3 Forms monomers and multimers. Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q70UZ7-1; Sequence=Displayed; Name=2; IsoId=Q70UZ7-2; Sequence=VSP_028740, VSP_028741; Detected in uterus, kidney, and skin. Also detected in intestine and lung of adult mice, and in calvaria, femur, brain, heart, intestine, skeletal muscle, and lung of newborn mice. First detected at days 7.5-8 dpc, when it is weakly expressed around the developing mesodermal cells. At day 10.5 dpc it is detected in the heart and the condensing somites, and at day 14.5 dpc it is present in the choroid plexus, the cochlea, the terminal bronchii of the lung, the heart, the skin, and in the cartilage primordium of the developing skeleton as well as in the interdigital spaces. Strong staining is seen in the condensed mesenchyme forming the edge of the developing teeth budding into the branchial arch and coinciding with the basement membrane that underlies the stratified squamous epithelia in the oral cavity. growth plate cartilage chondrocyte morphogenesis calcium ion binding extracellular region basement membrane extracellular space calcium-independent cell-matrix adhesion extracellular matrix identical protein binding regulation of insulin receptor signaling pathway protein homooligomerization uc008hzl.1 uc008hzl.2 uc008hzl.3 
ENSMUST00000026073.14 Trub1 ENSMUST00000026073.14 TruB pseudouridine (psi) synthase family member 1, transcript variant 1 (from RefSeq NM_028115.3) ENSMUST00000026073.1 ENSMUST00000026073.10 ENSMUST00000026073.11 ENSMUST00000026073.12 ENSMUST00000026073.13 ENSMUST00000026073.2 ENSMUST00000026073.3 ENSMUST00000026073.4 ENSMUST00000026073.5 ENSMUST00000026073.6 ENSMUST00000026073.7 ENSMUST00000026073.8 ENSMUST00000026073.9 NM_028115 Q5EBH7 Q8C0D0 Q9D331 TRUB1_MOUSE Trub1 uc008iag.1 uc008iag.2 uc008iag.3 uc008iag.4 Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity. Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28- binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation. Reaction=a uridine in mRNA = a pseudouridine in mRNA; Xref=Rhea:RHEA:56644, Rhea:RHEA-COMP:14658, Rhea:RHEA-COMP:14659, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Reaction=a uridine in tRNA = a pseudouridine in tRNA; Xref=Rhea:RHEA:54572, Rhea:RHEA-COMP:13339, Rhea:RHEA-COMP:13934, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Reaction=uridine(55) in tRNA = pseudouridine(55) in tRNA; Xref=Rhea:RHEA:42532, Rhea:RHEA-COMP:10101, Rhea:RHEA-COMP:10102, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.25; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42533; Evidence=; Nucleus Cytoplasm, cytosol Note=Catalyzes pseudouridylation of mRNAs in the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C0D0-1; Sequence=Displayed; Name=2; IsoId=Q8C0D0-2; Sequence=VSP_020860, VSP_020861; Belongs to the pseudouridine synthase TruB family. pseudouridine synthesis RNA binding nucleus cytoplasm mitochondrion cytosol RNA processing tRNA modification RNA modification pseudouridine synthase activity isomerase activity mRNA pseudouridine synthesis uc008iag.1 uc008iag.2 uc008iag.3 uc008iag.4 
ENSMUST00000026076.14 Gfra1 ENSMUST00000026076.14 glial cell line derived neurotrophic factor family receptor alpha 1, transcript variant 2 (from RefSeq NR_104342.1) ENSMUST00000026076.1 ENSMUST00000026076.10 ENSMUST00000026076.11 ENSMUST00000026076.12 ENSMUST00000026076.13 ENSMUST00000026076.2 ENSMUST00000026076.3 ENSMUST00000026076.4 ENSMUST00000026076.5 ENSMUST00000026076.6 ENSMUST00000026076.7 ENSMUST00000026076.8 ENSMUST00000026076.9 GFRA1_MOUSE Gdnfra NR_104342 O35246 O35252 P97785 Trnr1 uc008ian.1 uc008ian.2 uc008ian.3 uc008ian.4 This gene encodes a transmembrane protein that functions as the receptor for glial cell line derived neurotrophic factor (GDNF). The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the Ret tyrosine kinase in GDNF signaling pathway. Mice lacking the encoded protein exhibit deficits in the kidneys, the enteric nervous system, and spinal motor and sensory neurons similar mice deficient in GDNF or Ret. [provided by RefSeq, Jul 2016]. Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity). 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET (By similarity). Interacts with RET (By similarity). Interacts with SORL1, either alone or in complex with GDNF. Interaction between SORL1 and GFRA1 leads to GFRA1 internalization, but not degradation (By similarity). Cell membrane ; Lipid-anchor, GPI-anchor Golgi apparatus, trans-Golgi network Endosome Endosome, multivesicular body Note=Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=GDNFR-alpha; IsoId=P97785-1; Sequence=Displayed; Name=2; Synonyms=GDNFR-beta; IsoId=P97785-2; Sequence=VSP_041630; Expressed in the brain, in hippocampal neurons (at protein level) (PubMed:23333276). Isoform 1 and isoform 2 are expressed in heart, brain, lung, liver, kidney and testis. Belongs to the GDNFR family. neurotrophin receptor activity integrin binding extracellular space endosome multivesicular body Golgi apparatus plasma membrane transmembrane receptor protein tyrosine kinase signaling pathway nervous system development anatomical structure morphogenesis external side of plasma membrane membrane cell migration extrinsic component of membrane neuron differentiation axon neuron projection development anchored component of membrane signaling receptor activity neurotrophin signaling pathway neuronal cell body receptor complex positive regulation of peptidyl-tyrosine phosphorylation plasma membrane protein complex uc008ian.1 uc008ian.2 uc008ian.3 uc008ian.4 
ENSMUST00000026078.10 BC051665 ENSMUST00000026078.10 cDNA sequence BC051665 (from RefSeq NM_199148.2) BC051665 E9Q623 E9Q623_MOUSE ENSMUST00000026078.1 ENSMUST00000026078.2 ENSMUST00000026078.3 ENSMUST00000026078.4 ENSMUST00000026078.5 ENSMUST00000026078.6 ENSMUST00000026078.7 ENSMUST00000026078.8 ENSMUST00000026078.9 NM_199148 uc007qvp.1 uc007qvp.2 uc007qvp.3 Lysosome Belongs to the peptidase C1 family. cysteine-type endopeptidase activity extracellular space lysosome proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity proteolysis involved in cellular protein catabolic process uc007qvp.1 uc007qvp.2 uc007qvp.3 
ENSMUST00000026081.5 Pnliprp2 ENSMUST00000026081.5 pancreatic lipase-related protein 2 (from RefSeq NM_011128.2) ENSMUST00000026081.1 ENSMUST00000026081.2 ENSMUST00000026081.3 ENSMUST00000026081.4 LIPR2_MOUSE NM_011128 P17892 Plrp2 Pnliprp2 Q4VBW7 uc008iau.1 uc008iau.2 uc008iau.3 uc008iau.4 uc008iau.5 Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:21382969, PubMed:9813028). In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (PubMed:9813028). Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:21382969). Can completely deacylate triacylglycerols (By similarity). When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (By similarity). Hydrolyzes medium- and long-chain fatty acyls in galactolipids (By similarity). May act together with LIPF to hydrolyze partially digested triglycerides (By similarity). Hydrolyzes long-chain monoglycerides with high efficiency (By similarity). In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (PubMed:2302735, PubMed:9813028, PubMed:19451396). Also has low phospholipase activity (By similarity). In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12045; Evidence=; Reaction=a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3- beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+); Xref=Rhea:RHEA:13189, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15754, ChEBI:CHEBI:17615, ChEBI:CHEBI:28868; EC=3.1.1.26; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13190; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + di-(9Z)-octadecenoylglycerol + H(+); Xref=Rhea:RHEA:38575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38576; Evidence=; Reaction=di-(9Z)-octadecenoylglycerol + H2O = (9Z)-octadecenoate + (9Z- octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:47868, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75937, ChEBI:CHEBI:75945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47869; Evidence=; Reaction=(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:39955, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75937; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39956; Evidence=; Reaction=1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38488; Evidence=; Reaction=1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + H(+) + propanoate; Xref=Rhea:RHEA:48024, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17272, ChEBI:CHEBI:88153, ChEBI:CHEBI:88155; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48025; Evidence=; Reaction=1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+); Xref=Rhea:RHEA:40475, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:35020, ChEBI:CHEBI:76478; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40476; Evidence=; Reaction=1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + H(+) + octanoate; Xref=Rhea:RHEA:47864, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:76978, ChEBI:CHEBI:88066; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47865; Evidence=; Reaction=1,2-didecanoylglycerol + H2O = decanoate + decanoylglycerol + H(+); Xref=Rhea:RHEA:48596, ChEBI:CHEBI:11152, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:90605; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48597; Evidence=; Reaction=H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn- glycerol; Xref=Rhea:RHEA:48700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:90477, ChEBI:CHEBI:90770; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48701; Evidence=; Reaction=1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol; Xref=Rhea:RHEA:48696, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:90453, ChEBI:CHEBI:90769; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48697; Evidence=; Reaction=1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+); Xref=Rhea:RHEA:48540, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:90340, ChEBI:CHEBI:90515; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48541; Evidence=; Reaction=1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1- beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+); Xref=Rhea:RHEA:48536, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:90342, ChEBI:CHEBI:90514; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48537; Evidence=; Reaction=1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]- sn-glycerol + H2O = a fatty acid + acyl-3-O-[alpha-D-galactosyl- (1->6)-beta-D-galactosyl]-sn-glycerol + H(+); Xref=Rhea:RHEA:48372, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28396, ChEBI:CHEBI:28868, ChEBI:CHEBI:90310; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48373; Evidence=; Reaction=H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)- beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol; Xref=Rhea:RHEA:48708, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:90463, ChEBI:CHEBI:90774; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48709; Evidence=; Reaction=1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D- galactosyl]-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-O- [alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol; Xref=Rhea:RHEA:48692, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:90457, ChEBI:CHEBI:90768; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48693; Evidence=; Reaction=1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D- galactosyl]-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-O-[alpha- D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+); Xref=Rhea:RHEA:48516, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:90337, ChEBI:CHEBI:90359; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48517; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:44664, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:84465; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44665; Evidence=; CLPS stimulates triacylglycerol lipase activity (PubMed:21382969, PubMed:2302735). Triacylglycerol lipase activity is not inhibited by increasing bile salt concentration (PubMed:21382969). Glycerolipid metabolism; triacylglycerol degradation. Glycolipid metabolism. Secreted Zymogen granule membrane ; Peripheral membrane protein Cell projection, neuron projection Note=Localizes to neurite tips in neuronal cells. Expressed in acinar cells of pancreas (at protein level). Up-regulated in CD8-positive T cells by IL4/interleukin-4. Suckling mutant mice show inefficient fat digestion associated with fat malabsorption and decreased rates of weight gain. Belongs to the AB hydrolase superfamily. Lipase family. It is uncertain whether Met-1 or Met-15 is the initiator. phospholipase activity triglyceride lipase activity calcium ion binding extracellular region extracellular space lipid metabolic process cellular defense response phospholipid catabolic process response to bacterium lipid catabolic process lipase activity hydrolase activity galactolipid catabolic process zymogen granule membrane intestinal lipid catabolic process metal ion binding acylglycerol lipase activity galactolipase activity carboxylic ester hydrolase activity 1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity uc008iau.1 uc008iau.2 uc008iau.3 uc008iau.4 uc008iau.5 
ENSMUST00000026084.5 Slc18a2 ENSMUST00000026084.5 solute carrier family 18 (vesicular monoamine), member 2 (from RefSeq NM_172523.3) ENSMUST00000026084.1 ENSMUST00000026084.2 ENSMUST00000026084.3 ENSMUST00000026084.4 NM_172523 Q8BRU6 Q8CC55 VMAT2_MOUSE Vmat2 uc008ibi.1 uc008ibi.2 uc008ibi.3 uc008ibi.4 Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed:10618388) (By similarity). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (PubMed:9427251). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (PubMed:10618388) (By similarity). Reaction=2 H(+)(out) + serotonin(in) = 2 H(+)(in) + serotonin(out); Xref=Rhea:RHEA:73743, ChEBI:CHEBI:15378, ChEBI:CHEBI:350546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73744; Evidence=; Reaction=dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in); Xref=Rhea:RHEA:73739, ChEBI:CHEBI:15378, ChEBI:CHEBI:59905; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73740; Evidence=; Reaction=2 H(+)(out) + histamine(in) = 2 H(+)(in) + histamine(out); Xref=Rhea:RHEA:73755, ChEBI:CHEBI:15378, ChEBI:CHEBI:58432; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73756; Evidence=; Interacts with SLC6A3. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein Cell projection, axon Cell projection, dendrite Note=Sorted to large dense core granules in neuroendocrine cells, presumably at the level of the trans-Golgi network. In neurons it is predominantly detected in somatodendritic tubulovesicular membranes, a distinct population of secretory vesicles that undergo calcium-dependent exocytosis in axons and dendrites upon depolarization. Localized at synaptic vesicles in axons. Expressed in striata and substantia nigra. Mice are born at the expected Mendelian rate. The homozygous mutants show severe growth retardation and the majority die shortly after birth. Belongs to the major facilitator superfamily. Vesicular transporter family. response to amphetamine amine transmembrane transporter activity serotonin:sodium symporter activity protein binding cytoplasm integral component of plasma membrane neurotransmitter transport aging locomotory behavior synaptic vesicle drug binding monoamine transmembrane transporter activity response to toxic substance post-embryonic development aminergic neurotransmitter loading into synaptic vesicle monoamine transport membrane integral component of membrane enzyme binding insulin secretion integral component of synaptic vesicle membrane cytoplasmic vesicle membrane synaptic vesicle membrane dense core granule heat shock protein binding cytoplasmic vesicle cellular response to drug glucose homeostasis xenobiotic transport xenobiotic transporter activity cell projection neuron projection neuronal cell body terminal bouton axon terminus cell body negative regulation of neurotransmitter transport serotonin uptake transmembrane transport neurotransmitter loading into synaptic vesicle postsynapse neuronal dense core vesicle integral component of neuronal dense core vesicle membrane uc008ibi.1 uc008ibi.2 uc008ibi.3 uc008ibi.4 
ENSMUST00000026092.9 3110040N11Rik ENSMUST00000026092.9 RIKEN cDNA 3110040N11 gene, transcript variant 2 (from RefSeq NM_026077.5) CO040_MOUSE ENSMUST00000026092.1 ENSMUST00000026092.2 ENSMUST00000026092.3 ENSMUST00000026092.4 ENSMUST00000026092.5 ENSMUST00000026092.6 ENSMUST00000026092.7 ENSMUST00000026092.8 NM_026077 Q8K3A3 Q9CRC3 uc009icm.1 uc009icm.2 uc009icm.3 Belongs to the UPF0235 family. molecular_function cellular_component biological_process uc009icm.1 uc009icm.2 uc009icm.3 
ENSMUST00000026093.9 Btbd1 ENSMUST00000026093.9 BTB domain containing 1 (from RefSeq NM_146193.2) BTBD1_MOUSE ENSMUST00000026093.1 ENSMUST00000026093.2 ENSMUST00000026093.3 ENSMUST00000026093.4 ENSMUST00000026093.5 ENSMUST00000026093.6 ENSMUST00000026093.7 ENSMUST00000026093.8 Gsrp NM_146193 P58544 Q6GQU7 Q8BTZ0 Q8K0J0 uc009icn.1 uc009icn.2 Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (PubMed:15486563, PubMed:17462629). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (PubMed:15486563, PubMed:17462629). Protein modification; protein ubiquitination. Interacts (via C-terminus) with TOP1. Interacts with TRIM5 isoform Delta. Interacts with CUL3. Cytoplasm Note=Localizes to punctate or elongated cytoplasmic bodies. Strongly expressed in heart and skeletal muscle. Weakly expressed in myoblast C2C12 cells, but strongly up-regulated upon their differentiation into myotubes. Sequence=AAH31192.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; P-body cytoplasm cytosol muscle organ development protein ubiquitination neurogenesis cell differentiation macromolecular complex uc009icn.1 uc009icn.2 
ENSMUST00000026096.10 Bnc1 ENSMUST00000026096.10 basonuclin zinc finger protein 1 (from RefSeq NM_007562.2) Bnc1 ENSMUST00000026096.1 ENSMUST00000026096.2 ENSMUST00000026096.3 ENSMUST00000026096.4 ENSMUST00000026096.5 ENSMUST00000026096.6 ENSMUST00000026096.7 ENSMUST00000026096.8 ENSMUST00000026096.9 F8VPY0 F8VPY0_MOUSE NM_007562 uc009icu.1 uc009icu.2 uc009icu.3 uc009icu.4 nucleic acid binding nucleoplasm intracellular membrane-bounded organelle uc009icu.1 uc009icu.2 uc009icu.3 uc009icu.4 
ENSMUST00000026119.8 Gcgr ENSMUST00000026119.8 glucagon receptor (from RefSeq NM_008101.2) ENSMUST00000026119.1 ENSMUST00000026119.2 ENSMUST00000026119.3 ENSMUST00000026119.4 ENSMUST00000026119.5 ENSMUST00000026119.6 ENSMUST00000026119.7 GLR_MOUSE NM_008101 Q61606 Q63960 Q8K0B5 uc007mtc.1 uc007mtc.2 uc007mtc.3 uc007mtc.4 G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. Cell membrane ; Multi-pass membrane protein Note=Is rapidly internalized after ligand-binding. Expressed predominantly in liver, kidney, adrenal, lung and stomach, while lower levels of expression are detected in brown and white adipose tissue, cerebellum, duodenum and heart. Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding (By similarity). Mice are born at the expected Mendelian rate. They display pancreas islet and alpha-cell hyperplasia and increased glucagon levels, but normal insulin levels. Mice display low blood glucose levels combined with increased hepatic glycogen levels. They develop severe hypoglycemia after prolonged fasting. Mutant mice are fertile, but the females produce only few pups; half of the embryos die before birth, and liveborn pups do not survive more than one day. These pups are much smaller than their littermates and exhibit severe hypoglycemia. Belongs to the G-protein coupled receptor 2 family. transmembrane signaling receptor activity G-protein coupled receptor activity glucagon receptor activity endosome plasma membrane integral component of plasma membrane exocytosis signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway G-protein coupled peptide receptor activity hormone-mediated signaling pathway membrane integral component of membrane peptide hormone binding glucose homeostasis response to starvation regulation of glycogen metabolic process cellular response to glucagon stimulus uc007mtc.1 uc007mtc.2 uc007mtc.3 uc007mtc.4 
ENSMUST00000026120.8 Bhlhe22 ENSMUST00000026120.8 basic helix-loop-helix family, member e22 (from RefSeq NM_021560.4) A0A0R4J056 A0A0R4J056_MOUSE Bhlhe22 ENSMUST00000026120.1 ENSMUST00000026120.2 ENSMUST00000026120.3 ENSMUST00000026120.4 ENSMUST00000026120.5 ENSMUST00000026120.6 ENSMUST00000026120.7 NM_021560 uc008orl.1 uc008orl.2 uc008orl.3 uc008orl.4 RNA polymerase II transcription factor activity, sequence-specific DNA binding regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter neurogenesis protein dimerization activity uc008orl.1 uc008orl.2 uc008orl.3 uc008orl.4 
ENSMUST00000026121.3 Ppp1r27 ENSMUST00000026121.3 protein phosphatase 1, regulatory subunit 27 (from RefSeq NM_026814.3) A2ABX5 Dysfip1 ENSMUST00000026121.1 ENSMUST00000026121.2 NM_026814 PPR27_MOUSE Q9D119 uc007mth.1 uc007mth.2 uc007mth.3 Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Interacts with DYSF and PPP1CA. protein phosphatase inhibitor activity cellular_component negative regulation of phosphatase activity phosphatase binding negative regulation of phosphoprotein phosphatase activity uc007mth.1 uc007mth.2 uc007mth.3 
ENSMUST00000026122.11 P4hb ENSMUST00000026122.11 prolyl 4-hydroxylase, beta polypeptide (from RefSeq NM_011032.3) ENSMUST00000026122.1 ENSMUST00000026122.10 ENSMUST00000026122.2 ENSMUST00000026122.3 ENSMUST00000026122.4 ENSMUST00000026122.5 ENSMUST00000026122.6 ENSMUST00000026122.7 ENSMUST00000026122.8 ENSMUST00000026122.9 NM_011032 P09103 PDIA1_MOUSE Pdia1 Q922C8 uc007mti.1 uc007mti.2 uc007mti.3 This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP (By similarity). Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; Evidence=; Heterodimer; heterodimerizes with the protein microsomal triglyceride transfer MTTP. Homodimer. Monomers and homotetramers may also occur. Interacts with P4HA2, forming a heterotetramer consisting of 2 alpha subunits (P4HA2) and 2 beta (P4HB), where P4HB plays the role of a structural subunit; this tetramer catalyzes the formation of 4-hydroxyproline in collagen (PubMed:7753822). Also constitutes the structural subunit of the microsomal triacylglycerol transfer protein MTTP in mammalian cells. Stabilizes both enzymes and retain them in the ER without contributing to the catalytic activity. Binds UBQLN1. Interacts with ERO1B (By similarity). Interacts with ILDR2 (PubMed:33863978). Interacts with ERN1/IRE1A (via N-terminus); the interaction is enhanced by phosphorylation of P4HB by FAM20C in response to endoplasmic reticulum stress and results in attenuation of ERN1 activity (By similarity). Endoplasmic reticulum Endoplasmic reticulum lumen Melanosome Cell membrane ; Peripheral membrane protein Note=Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. Localizes near CD4-enriched regions on lymphoid cell surfaces. Colocalizes with MTTP in the endoplasmic reticulum. In the mammary gland, expressed at higher levels in lactating mice than in virgin mice. Phosphorylation of Ser-359 by FAM20C is induced by endoplasmic reticulum stress and results in a functional switch from oxidoreductase to molecular chaperone. It also promotes interaction with ERN1. Belongs to the protein disulfide isomerase family. protein disulfide isomerase activity procollagen-proline 4-dioxygenase activity integrin binding protein binding endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum-Golgi intermediate compartment plasma membrane protein folding external side of plasma membrane peptide disulfide oxidoreductase activity membrane procollagen-proline 4-dioxygenase complex isomerase activity peptidyl-proline hydroxylation to 4-hydroxy-L-proline enzyme binding endoplasmic reticulum chaperone complex response to endoplasmic reticulum stress melanosome cell redox homeostasis positive regulation of viral entry into host cell protein heterodimerization activity oxidation-reduction process cellular response to hypoxia cellular response to interleukin-7 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway uc007mti.1 uc007mti.2 uc007mti.3 
ENSMUST00000026125.3 Alyref ENSMUST00000026125.3 Aly/REF export factor (from RefSeq NM_011568.1) Aly ENSMUST00000026125.1 ENSMUST00000026125.2 NM_011568 O08583 Q0VBL5 Q8CBM4 Q9JJW7 Ref1 Refbp1 THOC4 THOC4_MOUSE uc007mtl.1 uc007mtl.2 uc007mtl.3 Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway) (PubMed:9119228, PubMed:10786854, PubMed:11158589). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription- independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability. Involved in mRNA export of C5-methylcytosine (m5C)- containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling (By similarity). Acts as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. Homomultimer (By similarity). Is part of several complexes involved in mRNA processing and export (By similarity). Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have a dynamic structure involving ATP-dependent remodeling; in the complex interacts (via C-terminus) directly with DDX39B and interacts directly with THOC1 and THOC2 (By similarity). Found in mRNA splicing-dependent exon junction complexes (EJC) (By similarity). Identified in the spliceosome C complex (By similarity). Found in a mRNP complex with UPF3A and UPF3B (By similarity). Interacts with RBM8A, NCBP1, THOC5, LEF1, RUNX1, EIF4A3, RNPS1, SRRM1, IWS1 and EXOSC1 (By similarity). Interacts with RBM15B. Interacts with NXF1; the interaction is direct (PubMed:10786854). Nucleus Nucleus speckle Cytoplasm Note=Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and DDX39B in the nucleus and nuclear speckles. Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Refbp1-I; IsoId=O08583-1; Sequence=Displayed; Name=2; Synonyms=Refbp1-II; IsoId=O08583-2; Sequence=VSP_008597; Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Arg-50 and Arg-203 are dimethylated, probably to asymmetric dimethylarginine. Arginine methylation reduces RNA binding (By similarity). Citrullinated by PADI4. Belongs to the THOC4 family. nucleic acid binding single-stranded DNA binding RNA binding nucleus spliceosomal complex cytoplasm mRNA processing RNA splicing nuclear speck mRNA transport uc007mtl.1 uc007mtl.2 uc007mtl.3 
ENSMUST00000026126.10 Ints4 ENSMUST00000026126.10 integrator complex subunit 4, transcript variant 1 (from RefSeq NM_027256.2) ENSMUST00000026126.1 ENSMUST00000026126.2 ENSMUST00000026126.3 ENSMUST00000026126.4 ENSMUST00000026126.5 ENSMUST00000026126.6 ENSMUST00000026126.7 ENSMUST00000026126.8 ENSMUST00000026126.9 INT4_MOUSE NM_027256 Q3TQQ4 Q8C2H1 Q8CIM8 Q91YV5 Q9CSY4 uc009iji.1 uc009iji.2 uc009iji.3 uc009iji.4 Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CIM8-1; Sequence=Displayed; Name=2; IsoId=Q8CIM8-2; Sequence=VSP_021456; Name=3; IsoId=Q8CIM8-3; Sequence=VSP_021454, VSP_021455; Belongs to the Integrator subunit 4 family. Sequence=AAH13813.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE37328.1; Type=Frameshift; Evidence=; molecular_function nucleus snRNA processing integrator complex uc009iji.1 uc009iji.2 uc009iji.3 uc009iji.4 
ENSMUST00000026128.10 Anapc11 ENSMUST00000026128.10 anaphase promoting complex subunit 11, transcript variant 2 (from RefSeq NM_025389.4) APC11_MOUSE ENSMUST00000026128.1 ENSMUST00000026128.2 ENSMUST00000026128.3 ENSMUST00000026128.4 ENSMUST00000026128.5 ENSMUST00000026128.6 ENSMUST00000026128.7 ENSMUST00000026128.8 ENSMUST00000026128.9 NM_025389 Q3UWH1 Q9CPX9 Q9CTG0 uc007mtm.1 uc007mtm.2 uc007mtm.3 Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). Protein modification; protein ubiquitination. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. Interacts with the cullin domain of ANAPC2. Interacts with UBE2D2. Cytoplasm Nucleus The RING-type zinc finger domain coordinates an additional third zinc ion. Auto-ubiquitinated. Belongs to the RING-box family. ubiquitin-protein transferase activity nucleus nucleoplasm anaphase-promoting complex nucleolus cytoplasm ubiquitin-dependent protein catabolic process cell cycle protein ubiquitination cullin-RING ubiquitin ligase complex ubiquitin-ubiquitin ligase activity positive regulation of mitotic metaphase/anaphase transition metal ion binding cell division ubiquitin protein ligase activity protein K11-linked ubiquitination cullin family protein binding uc007mtm.1 uc007mtm.2 uc007mtm.3 
ENSMUST00000026135.15 Aspscr1 ENSMUST00000026135.15 ASPSCR1 tether for SLC2A4, UBX domain containing, transcript variant 13 (from RefSeq NR_189303.1) A2ABZ7 A2AC06 ASPC1_MOUSE ENSMUST00000026135.1 ENSMUST00000026135.10 ENSMUST00000026135.11 ENSMUST00000026135.12 ENSMUST00000026135.13 ENSMUST00000026135.14 ENSMUST00000026135.2 ENSMUST00000026135.3 ENSMUST00000026135.4 ENSMUST00000026135.5 ENSMUST00000026135.6 ENSMUST00000026135.7 ENSMUST00000026135.8 ENSMUST00000026135.9 NR_189303 Q3UKD1 Q6V7K5 Q8VBT9 Q9CT64 Tug uc007mua.1 uc007mua.2 uc007mua.3 uc007mua.4 uc007mua.5 Enhances VCP methylation catalyzed by VCPKMT (By similarity). Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Interacts with VCP. Interacts with VCPKMT (By similarity). Interacts with GLUT4. Endomembrane system ; Peripheral membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Peripheral membrane protein. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=Q8VBT9-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q8VBT9-2; Sequence=VSP_020579; Name=3; IsoId=Q8VBT9-3; Sequence=VSP_020579, VSP_020580; Ubiquitous. protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane intracellular protein transport cytoplasmic side of plasma membrane endomembrane system vesicle membrane membrane extrinsic component of membrane cytoplasmic vesicle membrane positive regulation of protein modification process endoplasmic reticulum-Golgi intermediate compartment membrane glucose homeostasis intracellular membrane-bounded organelle regulation of glucose import perinuclear region of cytoplasm uc007mua.1 uc007mua.2 uc007mua.3 uc007mua.4 uc007mua.5 
ENSMUST00000026139.14 Lrrc45 ENSMUST00000026139.14 leucine rich repeat containing 45 (from RefSeq NM_153545.2) A2AC12 ENSMUST00000026139.1 ENSMUST00000026139.10 ENSMUST00000026139.11 ENSMUST00000026139.12 ENSMUST00000026139.13 ENSMUST00000026139.2 ENSMUST00000026139.3 ENSMUST00000026139.4 ENSMUST00000026139.5 ENSMUST00000026139.6 ENSMUST00000026139.7 ENSMUST00000026139.8 ENSMUST00000026139.9 LRC45_MOUSE NM_153545 Q3U5Z2 Q8CIM1 uc007mue.1 uc007mue.2 uc007mue.3 uc007mue.4 uc007mue.5 Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. Homomer. Interacts with CROCC/rootletin and CEP250. Interacts with CEP44. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to the proteinaceous linker between the proximal ends of the centrioles. Phosphorylated by NEK2 during misosis, phosphorylation reduces centrosomal localization which subsequently leads to centrosome separation. molecular_function nucleoplasm cytoplasm centrosome microtubule organizing center cytosol cytoskeleton plasma membrane biological_process uc007mue.1 uc007mue.2 uc007mue.3 uc007mue.4 uc007mue.5 
ENSMUST00000026142.8 Maged1 ENSMUST00000026142.8 MAGE family member D1, transcript variant 1 (from RefSeq NM_019791.3) ENSMUST00000026142.1 ENSMUST00000026142.2 ENSMUST00000026142.3 ENSMUST00000026142.4 ENSMUST00000026142.5 ENSMUST00000026142.6 ENSMUST00000026142.7 MAGD1_MOUSE NM_019791 Nrage Q543L6 Q99PB5 Q9CYX1 Q9QYH6 uc009ttn.1 uc009ttn.2 uc009ttn.3 Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl- conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A. Interacts with TRIM28 and PJA1. Interacts with NGFR/p75NTR and RORA. Q9QYH6; P70396: Dlx5; NbExp=2; IntAct=EBI-1801274, EBI-1801294; Q9QYH6; Q03358: Msx2; NbExp=5; IntAct=EBI-1801274, EBI-1801354; Q9QYH6; P25233: Ndn; NbExp=7; IntAct=EBI-1801274, EBI-1801080; Q9QYH6; O55176-2: Pja1; NbExp=2; IntAct=EBI-1801274, EBI-1801670; Q9QYH6; P51448: Rora; NbExp=5; IntAct=EBI-1801274, EBI-1169722; Nucleus Cytoplasm Cell membrane ; Peripheral membrane protein Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. Ubiquitously expressed in many adult tissues, except for the spleen. Expressed in osteoblastic and chondrogenic cell lines and also during embryonic development. Animals show shortened circadian period and reduced total activity. chromatin transcription coactivator activity protein binding nucleus cytoplasm cytosol plasma membrane regulation of transcription from RNA polymerase II promoter membrane circadian regulation of gene expression macromolecular complex regulation of circadian rhythm identical protein binding regulation of apoptotic process positive regulation of MAP kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated rhythmic process negative regulation of epithelial cell proliferation positive regulation of branching involved in ureteric bud morphogenesis negative regulation of protein localization to nucleus positive regulation of apoptotic signaling pathway uc009ttn.1 uc009ttn.2 uc009ttn.3 
ENSMUST00000026144.5 Dcxr ENSMUST00000026144.5 dicarbonyl L-xylulose reductase, transcript variant 1 (from RefSeq NM_026428.3) DCXR_MOUSE ENSMUST00000026144.1 ENSMUST00000026144.2 ENSMUST00000026144.3 ENSMUST00000026144.4 NM_026428 Q3U5L5 Q91X52 Q9D129 Q9D8W1 uc007mui.1 uc007mui.2 uc007mui.3 Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. Reaction=NADP(+) + xylitol = H(+) + L-xylulose + NADPH; Xref=Rhea:RHEA:17025, ChEBI:CHEBI:15378, ChEBI:CHEBI:17151, ChEBI:CHEBI:17399, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.10; Evidence=; Homotetramer. Membrane ; Peripheral membrane protein Apical cell membrane ; Peripheral membrane protein Note=Probably recruited to membranes via an interaction with phosphatidylinositol (By similarity). In kidney, it is localized in the brush border membranes of proximal tubular cells. Highly expressed in kidney, liver and epididymis. Expressed at intermediate level in lung. Weakly or not expressed in brain, heart, spleen and testis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. carbonyl reductase (NADPH) activity cytoplasmic microtubule plasma membrane microvillus brush border carbohydrate metabolic process xylulose metabolic process glucose metabolic process NADP metabolic process membrane apical plasma membrane oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor D-xylose metabolic process identical protein binding L-xylulose reductase (NAD+) activity L-xylulose reductase (NADP+) activity protein homotetramerization oxidation-reduction process uc007mui.1 uc007mui.2 uc007mui.3 
ENSMUST00000026148.9 Cbr2 ENSMUST00000026148.9 carbonyl reductase 2 (from RefSeq NM_007621.2) Cbr2 ENSMUST00000026148.1 ENSMUST00000026148.2 ENSMUST00000026148.3 ENSMUST00000026148.4 ENSMUST00000026148.5 ENSMUST00000026148.6 ENSMUST00000026148.7 ENSMUST00000026148.8 NM_007621 Q542P5 Q542P5_MOUSE uc007muj.1 uc007muj.2 uc007muj.3 uc007muj.4 Homotetramer. Belongs to the short-chain dehydrogenases/reductases (SDR) family. oxidoreductase activity oxidation-reduction process uc007muj.1 uc007muj.2 uc007muj.3 uc007muj.4 
ENSMUST00000026150.15 Arhgap19 ENSMUST00000026150.15 Rho GTPase activating protein 19, transcript variant 1 (from RefSeq NM_027667.3) B9EI55 ENSMUST00000026150.1 ENSMUST00000026150.10 ENSMUST00000026150.11 ENSMUST00000026150.12 ENSMUST00000026150.13 ENSMUST00000026150.14 ENSMUST00000026150.2 ENSMUST00000026150.3 ENSMUST00000026150.4 ENSMUST00000026150.5 ENSMUST00000026150.6 ENSMUST00000026150.7 ENSMUST00000026150.8 ENSMUST00000026150.9 NM_027667 Q0VGS7 Q5DU53 Q8BRH3 Q9D468 RHG19_MOUSE uc008hmh.1 uc008hmh.2 uc008hmh.3 uc008hmh.4 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BRH3-1; Sequence=Displayed; Name=2; IsoId=Q8BRH3-2; Sequence=VSP_023702; Sequence=AAH86680.1; Type=Erroneous initiation; Evidence=; GTPase activator activity cytoplasm plasma membrane signal transduction intracellular membrane-bounded organelle positive regulation of GTPase activity regulation of small GTPase mediated signal transduction uc008hmh.1 uc008hmh.2 uc008hmh.3 uc008hmh.4 
ENSMUST00000026154.9 Zdhhc16 ENSMUST00000026154.9 zinc finger, DHHC domain containing 16, transcript variant 2 (from RefSeq NM_023740.3) Aph2 ENSMUST00000026154.1 ENSMUST00000026154.2 ENSMUST00000026154.3 ENSMUST00000026154.4 ENSMUST00000026154.5 ENSMUST00000026154.6 ENSMUST00000026154.7 ENSMUST00000026154.8 NM_023740 Q3TI22 Q3UA59 Q91XC5 Q9ESG8 ZDH16_MOUSE Zdhhc16 uc008hmq.1 uc008hmq.2 uc008hmq.3 uc008hmq.4 Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:26644582). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (PubMed:26644582). Also required for eye development (PubMed:26644582). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (PubMed:27159997). May be involved in apoptosis regulation (PubMed:12021275). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; Interacts with ABL1 (PubMed:12021275). Interacts with COPS5 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Ubiquitously expressed. Lethality one day after birth (PubMed:26644582). Pups and embryos show eye malformation and heart defects (PubMed:26644582). Mice display cardiomyopathy and cardiac defects including bradycardia (PubMed:26644582). Heart defects are characterized by thinner and enlarged ventricular walls, cardiomyocyte disarray and abnormal nucleus morphology (PubMed:26644582). Belongs to the DHHC palmitoyltransferase family. eye development protein binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus apoptotic process cellular response to DNA damage stimulus heart development membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups protein palmitoylation protein-cysteine S-palmitoyltransferase activity telencephalon development uc008hmq.1 uc008hmq.2 uc008hmq.3 uc008hmq.4 
ENSMUST00000026156.8 Rfng ENSMUST00000026156.8 RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (from RefSeq NM_009053.2) B1ATU3 ENSMUST00000026156.1 ENSMUST00000026156.2 ENSMUST00000026156.3 ENSMUST00000026156.4 ENSMUST00000026156.5 ENSMUST00000026156.6 ENSMUST00000026156.7 NM_009053 O09009 RFNG_MOUSE Rfng uc007mum.1 uc007mum.2 uc007mum.3 Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1 (PubMed:28089369). May be involved in limb formation and in neurogenesis (By similarity). Reaction=3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl- (1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:70531, Rhea:RHEA-COMP:17922, Rhea:RHEA- COMP:17923, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:189631, ChEBI:CHEBI:189634; EC=2.4.1.222; Evidence=; Reaction=3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP- N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl- (1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:70511, Rhea:RHEA-COMP:17919, Rhea:RHEA- COMP:17920, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:189632, ChEBI:CHEBI:189633; EC=2.4.1.222; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Has some activity with cobalt but not with magnesium, calcium and zinc. ; Kinetic parameters: KM=53.6 uM for UDP-N-acetyl-alpha-D-glucosamine ; Vmax=1.6 nmol/min/mg enzyme ; Temperature dependence: Optimum temperature is 37 degrees Celsius. ; Golgi apparatus membrane ; Single- pass type II membrane protein Detected in all the examined tissues (12.5 dpc). High expression found in adult brain. Belongs to the glycosyltransferase 31 family. Golgi membrane Golgi apparatus multicellular organism development pattern specification process nervous system development regulation of Notch signaling pathway membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups cell differentiation integral component of Golgi membrane positive regulation of protein binding O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity protein O-linked fucosylation negative regulation of Notch signaling pathway positive regulation of Notch signaling pathway metal ion binding uc007mum.1 uc007mum.2 uc007mum.3 
ENSMUST00000026159.6 Cd7 ENSMUST00000026159.6 CD7 antigen (from RefSeq NM_009854.2) Cd7 ENSMUST00000026159.1 ENSMUST00000026159.2 ENSMUST00000026159.3 ENSMUST00000026159.4 ENSMUST00000026159.5 NM_009854 Q3U4A8 Q3U4A8_MOUSE uc007mvc.1 uc007mvc.2 uc007mvc.3 uc007mvc.4 uc007mvc.5 adaptive immune response membrane integral component of membrane signaling receptor activity uc007mvc.1 uc007mvc.2 uc007mvc.3 uc007mvc.4 uc007mvc.5 
ENSMUST00000026162.12 Sectm1a ENSMUST00000026162.12 secreted and transmembrane 1A (from RefSeq NM_145373.2) A2ABP9 A2ABP9_MOUSE ENSMUST00000026162.1 ENSMUST00000026162.10 ENSMUST00000026162.11 ENSMUST00000026162.2 ENSMUST00000026162.3 ENSMUST00000026162.4 ENSMUST00000026162.5 ENSMUST00000026162.6 ENSMUST00000026162.7 ENSMUST00000026162.8 ENSMUST00000026162.9 NM_145373 Sectm1a uc007mve.1 uc007mve.2 uc007mve.3 cytokine activity immune response signal transduction membrane integral component of membrane uc007mve.1 uc007mve.2 uc007mve.3 
ENSMUST00000026169.7 Ogfod3 ENSMUST00000026169.7 2-oxoglutarate and iron-dependent oxygenase domain containing 3 (from RefSeq NM_025402.2) ENSMUST00000026169.1 ENSMUST00000026169.2 ENSMUST00000026169.3 ENSMUST00000026169.4 ENSMUST00000026169.5 ENSMUST00000026169.6 NM_025402 OGFD3_MOUSE Q9D136 uc007mvk.1 uc007mvk.2 uc007mvk.3 Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Membrane ; Single-pass type II membrane protein Belongs to the OGFOD3 family. molecular_function iron ion binding membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen L-ascorbic acid binding metal ion binding dioxygenase activity oxidation-reduction process uc007mvk.1 uc007mvk.2 uc007mvk.3 
ENSMUST00000026170.3 Ubtd1 ENSMUST00000026170.3 ubiquitin domain containing 1 (from RefSeq NM_145500.3) ENSMUST00000026170.1 ENSMUST00000026170.2 NM_145500 Q91WB7 UBTD1_MOUSE uc008hmz.1 uc008hmz.2 uc008hmz.3 May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2. Interacts with UBTD1. molecular_function cellular_component biological_process uc008hmz.1 uc008hmz.2 uc008hmz.3 
ENSMUST00000026173.13 Wdr45b ENSMUST00000026173.13 WD repeat domain 45B (from RefSeq NM_025793.3) ENSMUST00000026173.1 ENSMUST00000026173.10 ENSMUST00000026173.11 ENSMUST00000026173.12 ENSMUST00000026173.2 ENSMUST00000026173.3 ENSMUST00000026173.4 ENSMUST00000026173.5 ENSMUST00000026173.6 ENSMUST00000026173.7 ENSMUST00000026173.8 ENSMUST00000026173.9 NM_025793 Q3U924 Q9CR39 WIPI3_MOUSE Wdr45l Wipi3 uc007mvt.1 uc007mvt.2 uc007mvt.3 uc007mvt.4 Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2. In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway. Interacts with the TSC1-TSC2 complex; stimulated upon starvation (By similarity). Interacts with RB1CC1 (PubMed:28561066). Interacts with ATG2A (By similarity). Preautophagosomal structure Lysosome The L/FRRG motif is required for recruitment to PtdIns3P. Belongs to the WD repeat PROPPIN family. autophagosome assembly pre-autophagosomal structure mitophagy lysosome cytosol protein lipidation autophagy lipid binding cellular response to starvation extrinsic component of membrane phosphatidylinositol-3-phosphate binding pre-autophagosomal structure membrane protein localization to pre-autophagosomal structure phosphatidylinositol-3,5-bisphosphate binding uc007mvt.1 uc007mvt.2 uc007mvt.3 uc007mvt.4 
ENSMUST00000026175.9 Fn3k ENSMUST00000026175.9 fructosamine 3 kinase, transcript variant 1 (from RefSeq NM_022014.4) ENSMUST00000026175.1 ENSMUST00000026175.2 ENSMUST00000026175.3 ENSMUST00000026175.4 ENSMUST00000026175.5 ENSMUST00000026175.6 ENSMUST00000026175.7 ENSMUST00000026175.8 FN3K_MOUSE Fn3k NM_022014 Q9D6N6 Q9ER35 uc007mvx.1 uc007mvx.2 uc007mvx.3 uc007mvx.4 Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:16819943). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (By similarity). Involved in intracellular deglycation in erythrocytes and pancreatic islets (PubMed:16819943, PubMed:20009024). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (PubMed:31398338). Also able to phosphorylate psicosamines and ribulosamines (By similarity). Reaction=ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]; Xref=Rhea:RHEA:59832, Rhea:RHEA-COMP:15451, Rhea:RHEA-COMP:15452, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:143253, ChEBI:CHEBI:143254, ChEBI:CHEBI:456216; EC=2.7.1.171; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59833; Evidence=; Reaction=ATP + N(6)-D-ribulosyl-L-lysyl-[protein] = ADP + H(+) + N(6)- (3-O-phospho-D-ribulosyl)-L-lysyl-[protein]; Xref=Rhea:RHEA:48432, Rhea:RHEA-COMP:12103, Rhea:RHEA-COMP:12104, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:90418, ChEBI:CHEBI:90420, ChEBI:CHEBI:456216; EC=2.7.1.172; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48433; Evidence=; Reaction=ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)- (3-O-phospho-D-psicosyl)-L-lysyl-[protein]; Xref=Rhea:RHEA:61392, Rhea:RHEA-COMP:15796, Rhea:RHEA-COMP:15797, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:144621, ChEBI:CHEBI:144622, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61393; Evidence=; Monomer. Expressed in red blood cells, brain, heart, kidney and muscle (PubMed:15331600). Lower expression is observed in liver (PubMed:15331600). Not expressed in lung, spleen, testis and thymus (PubMed:15331600). Mice are viable and healthy and show normal blood glucose and serum fructosamine levels (PubMed:16819943). They however display increased protein glycation levels in cells such as erythrocytes and pancreatic islets (PubMed:16819943, PubMed:20009024). Increased levels of protein glycation levels do not affect the maintenance and function of pancreatic islets (PubMed:20009024). Belongs to the fructosamine kinase family. Sequence=AK010151; Type=Frameshift; Evidence=; cytosol kinase activity phosphorylation transferase activity fructosamine-3-kinase activity fructosamine metabolic process epithelial cell differentiation uc007mvx.1 uc007mvx.2 uc007mvx.3 uc007mvx.4 
ENSMUST00000026188.10 R3hcc1l ENSMUST00000026188.10 R3H domain and coiled-coil containing 1 like (from RefSeq NM_177464.4) D19Ertd386e ENSMUST00000026188.1 ENSMUST00000026188.2 ENSMUST00000026188.3 ENSMUST00000026188.4 ENSMUST00000026188.5 ENSMUST00000026188.6 ENSMUST00000026188.7 ENSMUST00000026188.8 ENSMUST00000026188.9 Gidrp88 NM_177464 Q3UGJ8 Q5U5U8 Q8BJM3 R3HCL_MOUSE uc008hnq.1 uc008hnq.2 uc008hnq.3 May interact with the exon junction complex (EJC) composed at least of CASC3, EIF4A3, MAGOH and RBM8A. molecular_function biological_process exon-exon junction complex uc008hnq.1 uc008hnq.2 uc008hnq.3 
ENSMUST00000026190.14 Loxl4 ENSMUST00000026190.14 lysyl oxidase-like 4, transcript variant 2 (from RefSeq NM_053083.3) E9PXI3 ENSMUST00000026190.1 ENSMUST00000026190.10 ENSMUST00000026190.11 ENSMUST00000026190.12 ENSMUST00000026190.13 ENSMUST00000026190.2 ENSMUST00000026190.3 ENSMUST00000026190.4 ENSMUST00000026190.5 ENSMUST00000026190.6 ENSMUST00000026190.7 ENSMUST00000026190.8 ENSMUST00000026190.9 LOXL4_MOUSE Loxc NM_053083 Q924C6 uc008hns.1 uc008hns.2 uc008hns.3 uc008hns.4 May modulate the formation of a collagenous extracellular matrix. Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Name=lysine tyrosylquinone residue; Xref=ChEBI:CHEBI:20489; Evidence=; Note=Contains 1 lysine tyrosylquinone. ; Secreted, extracellular space The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Belongs to the lysyl oxidase family. protein-lysine 6-oxidase activity scavenger receptor activity copper ion binding extracellular region extracellular space endocytosis membrane oxidoreductase activity oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor peptidyl-lysine oxidation collagen fibril organization receptor complex metal ion binding oxidation-reduction process uc008hns.1 uc008hns.2 uc008hns.3 uc008hns.4 
ENSMUST00000026196.14 Got1 ENSMUST00000026196.14 glutamic-oxaloacetic transaminase 1, soluble (from RefSeq NM_010324.2) AATC_MOUSE ENSMUST00000026196.1 ENSMUST00000026196.10 ENSMUST00000026196.11 ENSMUST00000026196.12 ENSMUST00000026196.13 ENSMUST00000026196.2 ENSMUST00000026196.3 ENSMUST00000026196.4 ENSMUST00000026196.5 ENSMUST00000026196.6 ENSMUST00000026196.7 ENSMUST00000026196.8 ENSMUST00000026196.9 Got1 NM_010324 P05201 Q3UJH8 uc012bmb.1 uc012bmb.2 uc012bmb.3 Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. Reaction=2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate; Xref=Rhea:RHEA:21824, ChEBI:CHEBI:16452, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:29991; EC=2.6.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21825; Evidence=; Reaction=2-oxoglutarate + L-cysteine = 2-oxo-3-sulfanylpropanoate + L- glutamate; Xref=Rhea:RHEA:17441, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:35235, ChEBI:CHEBI:57678; EC=2.6.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17442; Evidence=; Reaction=(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L- glutamate; Xref=Rhea:RHEA:70223, ChEBI:CHEBI:16763, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:74359; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70225; Evidence=; Reaction=2-oxoglutarate + 3-sulfino-L-alanine = 3-sulfinopyruvate + L- glutamate; Xref=Rhea:RHEA:70295, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:61085, ChEBI:CHEBI:140699; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70297; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Inhibited by calcium ions. Homodimer. Cytoplasm. Expressed in neurons of the retina. Localizes to the inner and outer plexiform layers, the inner and outer nuclear layer and the outer segments of photoreceptors. In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. catalytic activity L-aspartate:2-oxoglutarate aminotransferase activity phosphatidylserine decarboxylase activity nucleoplasm cytoplasm lysosome cytosol 2-oxoglutarate metabolic process oxaloacetate metabolic process glycerol biosynthetic process cellular amino acid metabolic process aspartate metabolic process aspartate biosynthetic process aspartate catabolic process glutamate metabolic process Notch signaling pathway transaminase activity cellular amino acid biosynthetic process biosynthetic process response to carbohydrate transferase activity glutamate catabolic process to aspartate glutamate catabolic process to 2-oxoglutarate pyridoxal phosphate binding positive regulation of transforming growth factor beta receptor signaling pathway carboxylic acid binding cellular response to insulin stimulus negative regulation of collagen biosynthetic process response to immobilization stress dicarboxylic acid metabolic process axon terminus response to cadmium ion L-cysteine:2-oxoglutarate aminotransferase activity response to glucocorticoid negative regulation of cytosolic calcium ion concentration negative regulation of mitochondrial depolarization fatty acid homeostasis transdifferentiation cellular response to mechanical stimulus response to transition metal nanoparticle uc012bmb.1 uc012bmb.2 uc012bmb.3 
ENSMUST00000026208.6 Abcc2 ENSMUST00000026208.6 ATP-binding cassette, sub-family member 2 (from RefSeq NM_013806.2) Abcc2 ENSMUST00000026208.1 ENSMUST00000026208.2 ENSMUST00000026208.3 ENSMUST00000026208.4 ENSMUST00000026208.5 MRP2_MOUSE NM_013806 Q8VI46 Q8VI47 uc008how.1 uc008how.2 uc008how.3 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the canalicular surface of the hepatocyte and in biliary transport, and appears to contribute to drug resistance in mammalian cells. Several different mutations in the human gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Alternative splice variants have been observed for this gene; however, they have not been fully described. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF282772.1, AF282773.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)- conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification. Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate. Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors. Reaction=an S-substituted glutathione(in) + ATP + H2O = ADP + an S- substituted glutathione(out) + H(+) + phosphate; Xref=Rhea:RHEA:19121, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:90779, ChEBI:CHEBI:456216; EC=7.6.2.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19122; Evidence=; Reaction=ATP + H2O + taurolithocholate 3-sulfate(in) = ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out); Xref=Rhea:RHEA:50084, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58301, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50085; Evidence=; Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.; EC=7.6.2.2; Evidence=; Reaction=ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate; Xref=Rhea:RHEA:38963, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57973, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38964; Evidence=; Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:82961, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60129; Evidence=; Reaction=ATP + bilirubin-glucuronoside(in) + H2O = ADP + bilirubin- glucuronoside(out) + H(+) + phosphate; Xref=Rhea:RHEA:66180, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57767, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66181; Evidence=; Reaction=ATP + bilirubin-bisglucuronoside(in) + H2O = ADP + bilirubin- bisglucuronoside(out) + H(+) + phosphate; Xref=Rhea:RHEA:66192, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58471, ChEBI:CHEBI:456216; Evidence=; Apical cell membrane ; Multi-pass membrane protein Expressed in liver. These mice are healthy and show no phenotypic abnormalities. Mice display hyperbilirubinemia and reduced levels of biliary GSH. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. nucleotide binding protein binding ATP binding plasma membrane integral component of plasma membrane drug transmembrane transport response to oxidative stress female pregnancy organic anion transmembrane transporter activity xenobiotic-transporting ATPase activity response to heat cell surface mercury ion transport bile acid and bile salt transport canalicular bile acid transport prostaglandin transport membrane integral component of membrane apical plasma membrane ATPase activity antibiotic metabolic process protein domain specific binding transmembrane transporter activity cellular chloride ion homeostasis response to methotrexate brush border membrane response to lipopolysaccharide response to glucagon response to drug ATPase activity, coupled to transmembrane movement of substances xenobiotic transport xenobiotic transporter activity response to estrogen intercellular canaliculus response to arsenic-containing substance response to steroid hormone transmembrane transport thyroid hormone transport cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to dexamethasone stimulus response to antineoplastic agent benzylpenicillin metabolic process uc008how.1 uc008how.2 uc008how.3 
ENSMUST00000026210.5 Cpn1 ENSMUST00000026210.5 carboxypeptidase N, polypeptide 1 (from RefSeq NM_030703.2) CBPN_MOUSE ENSMUST00000026210.1 ENSMUST00000026210.2 ENSMUST00000026210.3 ENSMUST00000026210.4 NM_030703 Q91WM9 Q9JJN5 uc008hpa.1 uc008hpa.2 uc008hpa.3 uc008hpa.4 Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Reaction=Release of a C-terminal basic amino acid, preferentially lysine.; EC=3.4.17.3; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Tetramer of two catalytic chains and two glycosylated inactive chains. Secreted, extracellular space Mainly expressed in liver. Also detected in lung, stomach, intestine, spleen and kidney. Belongs to the peptidase M14 family. carboxypeptidase activity metallocarboxypeptidase activity extracellular region extracellular space proteolysis peptide metabolic process peptidase activity metallopeptidase activity zinc ion binding bradykinin catabolic process protein processing hydrolase activity metal ion binding response to glucocorticoid uc008hpa.1 uc008hpa.2 uc008hpa.3 uc008hpa.4 
ENSMUST00000026211.10 Cyp2c23 ENSMUST00000026211.10 cytochrome P450, family 2, subfamily c, polypeptide 23, transcript variant 1 (from RefSeq NM_001001446.3) CP2CN_MOUSE Cyp2c23 Cyp2c44 E9Q5K4 ENSMUST00000026211.1 ENSMUST00000026211.2 ENSMUST00000026211.3 ENSMUST00000026211.4 ENSMUST00000026211.5 ENSMUST00000026211.6 ENSMUST00000026211.7 ENSMUST00000026211.8 ENSMUST00000026211.9 NM_001001446 Q6IEF7 Q8BWN7 Q8QZW4 uc008hpc.1 uc008hpc.2 uc008hpc.3 uc008hpc.4 A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling (PubMed:15084647). Catalyzes preferentially the epoxidation of double bonds of PUFAs (PubMed:15084647). Converts arachidonic acid (ARA, C20:4(n-6)) primarily to stereospecific products 8R,9S-epoxyeicosatrienoate (EET) and 11R,12S-EET (PubMed:15084647). Plays a major role in the formation of EETs and hydroxy-EETs (HEETs) in kidney. Via EETs may inhibit the epithelial sodium channels (ENaCs) in nephron segments, preventing excessive sodium absorption during high dietary salt intake (PubMed:24966089, PubMed:24368771). Participates in the formation of anti-inflammatory hydroxyepoxyeicosatrienoic acids (HEETs) by converting 20-hydroxyeicosatetraenoic acid (20-HETE) to 20,8,9-HEET, an activator of PPARA (By similarity). Metabolizes eicosapentaenoic acid (EPA, C20:5(n-3)) to epoxyeicosatetraenoic acid (EETeTr) regioisomers, 8,9-, 11,12-, 14,15-, and 17,18- EETeTr, preferentially producing 17R,18S enantiomer (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15084647). Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49884, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49885; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49880, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131970; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49881; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51472, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:84024; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51473; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52168, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:136439; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52169; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z,17Z)- eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52172, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:136441; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52173; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z,17Z)- eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52176, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:136443; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52177; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)- eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39779, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76634; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39780; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)- eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39783, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76635; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39784; Evidence=; Reaction=20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)- eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:64980, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76624, ChEBI:CHEBI:137474; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64981; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Lipid metabolism; arachidonate metabolism. Endoplasmic reticulum membrane Microsome membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q5K4-1; Sequence=Displayed; Name=2; IsoId=E9Q5K4-2; Sequence=VSP_060520, VSP_060521; Highly expressed in liver, particularly in hepatocytes and bile duct epithelial cells (at protein level) (PubMed:24966089). Expressed in nephron segments (PubMed:24966089, PubMed:15084647). Prominent expression is detected in proximal tubules at the corticomedullary junction (at protein level) (PubMed:15084647). Also expressed in renal cortical collecting duct (PubMed:15084647). Lower expression levels are detected in adrenal glands (PubMed:15084647). Up-regulated by high sodium or high potassium diets. High sodium intake increases expression in thick ascending limb and distal convoluted tubule. An increase in dietary potassium intake induces expression in distal convoluted tubule and cortical collecting duct. Mutant mice have normal development and lack symptoms of disease or organ malformation (PubMed:24368771). Become hypertensive in response to high sodium or high potassium diets (PubMed:24368771, PubMed:24966089). Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc008hpc.1 uc008hpc.2 uc008hpc.3 uc008hpc.4 
ENSMUST00000026217.11 Chuk ENSMUST00000026217.11 conserved helix-loop-helix ubiquitous kinase, transcript variant 1 (from RefSeq NM_007700.2) Chuk E9QNL4 E9QNL4_MOUSE ENSMUST00000026217.1 ENSMUST00000026217.10 ENSMUST00000026217.2 ENSMUST00000026217.3 ENSMUST00000026217.4 ENSMUST00000026217.5 ENSMUST00000026217.6 ENSMUST00000026217.7 ENSMUST00000026217.8 ENSMUST00000026217.9 NM_007700 uc008hpg.1 uc008hpg.2 uc008hpg.3 uc008hpg.4 Reaction=ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L- seryl-[I-kappa-B protein]; Xref=Rhea:RHEA:19073, Rhea:RHEA- COMP:13698, Rhea:RHEA-COMP:13699, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.10; Evidence=; Cytoplasm Nucleus skeletal muscle contraction protein kinase activity ATP binding nucleoplasm cytosol protein phosphorylation I-kappaB kinase/NF-kappaB signaling I-kappaB phosphorylation Rho protein signal transduction IkappaB kinase activity IkappaB kinase complex response to toxic substance response to organic substance response to acetate negative regulation of NF-kappaB transcription factor activity response to lipopolysaccharide response to hydroperoxide cellular response to reactive oxygen species NIK/NF-kappaB signaling response to drug protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling response to amino acid intracellular membrane-bounded organelle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity striated muscle cell differentiation cellular response to cadmium ion cellular response to tumor necrosis factor scaffold protein binding cellular response to virus positive regulation of interferon-alpha secretion uc008hpg.1 uc008hpg.2 uc008hpg.3 uc008hpg.4 
ENSMUST00000026218.7 Cwf19l1 ENSMUST00000026218.7 CWF19 like cell cycle control factor 1, transcript variant 2 (from RefSeq NM_001356578.1) C19L1_MOUSE E9QNL3 ENSMUST00000026218.1 ENSMUST00000026218.2 ENSMUST00000026218.3 ENSMUST00000026218.4 ENSMUST00000026218.5 ENSMUST00000026218.6 NM_001356578 Q05CB7 Q3UT85 Q8C2J2 Q8CI33 uc008hpj.1 uc008hpj.2 uc008hpj.3 uc008hpj.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CI33-1; Sequence=Displayed; Name=2; IsoId=Q8CI33-2; Sequence=VSP_030589; Belongs to the CWF19 family. Sequence=AAH27553.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; mRNA splicing, via spliceosome positive regulation of catalytic activity RNA lariat debranching enzyme activator activity post-mRNA release spliceosomal complex uc008hpj.1 uc008hpj.2 uc008hpj.3 uc008hpj.4 
ENSMUST00000026220.7 Scd3 ENSMUST00000026220.7 stearoyl-coenzyme A desaturase 3 (from RefSeq NM_024450.2) ENSMUST00000026220.1 ENSMUST00000026220.2 ENSMUST00000026220.3 ENSMUST00000026220.4 ENSMUST00000026220.5 ENSMUST00000026220.6 NM_024450 Q3UWK5 Q99PL7 Q9D550 SCD3_MOUSE Scd3 uc008hpn.1 uc008hpn.2 uc008hpn.3 Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA (PubMed:16443825, PubMed:26098370). Has a strong preference for saturated fatty acids with chain lengths of 14 or 16 carbon atoms (C14:0 and C16:0), and has only very low activity with stearatate (C18:0) (PubMed:16443825, PubMed:26098370). Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:36931, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57379, ChEBI:CHEBI:61540; Evidence= Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Expected to bind 2 Fe(2+) ions per subunit. ; Endoplasmic reticulum membrane ; Multi-pass membrane protein Microsome membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99PL7-1; Sequence=Displayed; Name=2; IsoId=Q99PL7-2; Sequence=VSP_057848; Detected in skin, but at lower levels compared to Scd1. Detected in the middlle part of the sebaceous gland, but not in hair follicle. Not detected in liver and brain. Expression is increased during the first eight days (anagen) of the hair cycle in male mice, and is low during the quiescent phase (telogen) of the hair cycle. Expression is very low throughout the hair cycle in female mice. The histidine box domains are involved in binding the catalytic metal ions. Belongs to the fatty acid desaturase type 1 family. stearoyl-CoA 9-desaturase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water integral component of endoplasmic reticulum membrane organelle membrane palmitoyl-CoA 9-desaturase activity intracellular membrane-bounded organelle metal ion binding oxidation-reduction process response to fatty acid monounsaturated fatty acid biosynthetic process uc008hpn.1 uc008hpn.2 uc008hpn.3 
ENSMUST00000026221.7 Scd2 ENSMUST00000026221.7 stearoyl-Coenzyme A desaturase 2 (from RefSeq NM_009128.2) ENSMUST00000026221.1 ENSMUST00000026221.2 ENSMUST00000026221.3 ENSMUST00000026221.4 ENSMUST00000026221.5 ENSMUST00000026221.6 NM_009128 P13011 Q8BH96 SCD2_MOUSE uc008hpp.1 uc008hpp.2 uc008hpp.3 uc008hpp.4 uc008hpp.5 Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:16443825). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:16443825). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:16443825). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides, especially during embryonic development and in neonates (PubMed:16118274). Important for normal permeability barrier function of the skin in neonates (PubMed:16118274). Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:19721, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57387, ChEBI:CHEBI:57394; EC=1.14.19.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19722; Evidence=; Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:36931, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57379, ChEBI:CHEBI:61540; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36932; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Expected to bind 2 Fe(2+) ions per subunit. ; Endoplasmic reticulum membrane ; Multi-pass membrane protein Microsome membrane Detected in brain and skin (PubMed:10545940, PubMed:11161812, PubMed:16118274). Highly expressed in brain, and detected at low levels in heart, stomach, lung and testis (PubMed:11161812, PubMed:12815040). Detected both in dermis and epidermis (PubMed:16118274). Highly expressed during embryonic development and during the first three weeks after birth. Expression is low in adults. Up-regulated by agonists that activate NR1H3 (PubMed:12815040). Slightly down-regulated by a high-carbohydrate diet enriched in unsaturated fatty acids (PubMed:12815040). The histidine box domains are involved in binding the catalytic metal ions. Mutant mice are born at the expected Mendelian rate. Neonates are smaller than wild-type and present high mortality, ranging from 70 to 100%, depending on the genetic background. Neonates display a shiny skin, but after a few hours their skin appears dry and cracked. The permeability barrier function of their skin is impaired, leading to rapid weight loss due to dehydration. Their epidermis has decreased levels of cholesterol esters, triglycerides, acylceramide, and glucosylacylceramide containing unsaturated fatty acids. In mutant neonates, triglyceride levels in liver and blood plasma are reduced by half, due to strongly reduced levels of stearoyl-CoA desaturase activity in the liver and strongly reduced levels of triglyceride biosynthesis. In contrast, the levels of stearoyl-CoA desaturase activity are normal in adult mice deficient for Scd2. Adult mice display kinked tails. Belongs to the fatty acid desaturase type 1 family. stearoyl-CoA 9-desaturase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water integral component of endoplasmic reticulum membrane organelle membrane palmitoyl-CoA 9-desaturase activity intracellular membrane-bounded organelle metal ion binding oxidation-reduction process response to fatty acid monounsaturated fatty acid biosynthetic process uc008hpp.1 uc008hpp.2 uc008hpp.3 uc008hpp.4 uc008hpp.5 
ENSMUST00000026222.11 Ndufb8 ENSMUST00000026222.11 NADH:ubiquinone oxidoreductase subunit B8, transcript variant 1 (from RefSeq NM_026061.3) ENSMUST00000026222.1 ENSMUST00000026222.10 ENSMUST00000026222.2 ENSMUST00000026222.3 ENSMUST00000026222.4 ENSMUST00000026222.5 ENSMUST00000026222.6 ENSMUST00000026222.7 ENSMUST00000026222.8 ENSMUST00000026222.9 NDUB8_MOUSE NM_026061 Q9D6J5 Q9D6M7 uc008hpw.1 uc008hpw.2 uc008hpw.3 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side Belongs to the complex I NDUFB8 subunit family. molecular_function NADH dehydrogenase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I endoplasmic reticulum mitochondrial electron transport, NADH to ubiquinone NADH dehydrogenase (ubiquinone) activity membrane integral component of membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc008hpw.1 uc008hpw.2 uc008hpw.3 
ENSMUST00000026225.15 Sema4g ENSMUST00000026225.15 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G, transcript variant 2 (from RefSeq NM_011976.2) ENSMUST00000026225.1 ENSMUST00000026225.10 ENSMUST00000026225.11 ENSMUST00000026225.12 ENSMUST00000026225.13 ENSMUST00000026225.14 ENSMUST00000026225.2 ENSMUST00000026225.3 ENSMUST00000026225.4 ENSMUST00000026225.5 ENSMUST00000026225.6 ENSMUST00000026225.7 ENSMUST00000026225.8 ENSMUST00000026225.9 NM_011976 Q9WUH7 SEM4G_MOUSE uc008hqf.1 uc008hqf.2 uc008hqf.3 Cell surface receptor for PLXNB2. May play a role in axon guidance. Interacts with PLXNB2. Cell membrane; Single-pass type I membrane protein. Brain, spinal cord, and several sensory organs as well as specific populations of projection neurons. Expressed early in development. No visible phenotype. Belongs to the semaphorin family. neural crest cell migration protein binding extracellular space plasma membrane integral component of plasma membrane multicellular organism development nervous system development membrane integral component of membrane cell differentiation semaphorin receptor binding positive regulation of cell migration chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway uc008hqf.1 uc008hqf.2 uc008hqf.3 
ENSMUST00000026227.3 Twnk ENSMUST00000026227.3 twinkle mtDNA helicase, transcript variant 1 (from RefSeq NM_153796.4) ENSMUST00000026227.1 ENSMUST00000026227.2 NM_153796 PEO1_MOUSE Peo1 Q8CIW5 Q8K1Z1 Twnk uc008hqi.1 uc008hqi.2 Mitochondrial helicase involved in mtDNA replication and repair (By similarity). Might have a role in mtDNA repair (By similarity). Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB (By similarity). Preferentially unwinds DNA substrates with pre- existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate (By similarity). Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand (By similarity). In addition to its DNA strand separation activity, also has DNA strand annealing, DNA strand-exchange and DNA branch migration activities (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.3; Evidence=; Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.; EC=5.6.2.3; Evidence=; Homohexamer (via C-terminus), which assembles in a ring-like structure (By similarity). Homoheptamer, which assembles in a ring-like structure (By similarity). Homooctamer, which assembles in a ring-like structure (By similarity). Oligomers may sequentially eject two monomers (octamer>heptamer>hexamer) upon DNA binding (By similarity). Oligomerization is Mg(2+), nucleotide and DNA-independent, however, Mg(2+) and nucleotide stabilize the homohexameric form (By similarity). Interacts with POLG in vitro. Interacts with LONP1. Mitochondrion matrix, mitochondrion nucleoid Mitochondrion inner membrane ; Peripheral membrane protein Note=Colocalizes with mtDNA in mitochondrial nucleoids, a nucleoproteins complex consisting of a number of copies of proteins associated with mtDNA, probably involved in mtDNA maintenance and expression (By similarity). Associates with phospholipid membranes via electrostatic binding (By similarity). Preferentially associates with membranes enriched with cardiolipin, a lipid abundant in the mitochondrial inner membrane (By similarity). ATPase and helicase activity is enhanced by binding to lipid membranes (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CIW5-1; Sequence=Displayed; Name=2; IsoId=Q8CIW5-2; Sequence=VSP_015962, VSP_015963; Ubiquitous with the highest levels in the liver, heart and kidneys. The skeletal muscle, brain and testis showed lower but detectable expression. Expression is coregulated with MRPL43. N-terminus enhances protein stability and hexamer formation, which is important for DNA binding, and is required for DNA helicase activity and, ultimately, for mtDNA replisome processivity. The N-terminus contains a putative primase-like domain; however the absence of the zinc binding domain and other motifs important for catalysis suggests that TWNK lacks primase activity. nucleotide binding protease binding DNA helicase activity single-stranded DNA binding helicase activity ATP binding mitochondrion DNA replication mitochondrial DNA replication DNA unwinding involved in DNA replication transcription from mitochondrial promoter hydrolase activity protein hexamerization mitochondrial nucleoid 5'-3' DNA helicase activity protein homooligomerization cellular response to glucose stimulus uc008hqi.1 uc008hqi.2 
ENSMUST00000026236.11 Tlx1 ENSMUST00000026236.11 T cell leukemia, homeobox 1 (from RefSeq NM_021901.3) ENSMUST00000026236.1 ENSMUST00000026236.10 ENSMUST00000026236.2 ENSMUST00000026236.3 ENSMUST00000026236.4 ENSMUST00000026236.5 ENSMUST00000026236.6 ENSMUST00000026236.7 ENSMUST00000026236.8 ENSMUST00000026236.9 Hox11 NM_021901 Q9QX99 Q9QX99_MOUSE Tlx1 uc008hqu.1 uc008hqu.2 uc008hqu.3 Nucleus RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc008hqu.1 uc008hqu.2 uc008hqu.3 
ENSMUST00000026239.7 Poll ENSMUST00000026239.7 polymerase (DNA directed), lambda, transcript variant 1 (from RefSeq NM_020032.3) DPOLL_MOUSE ENSMUST00000026239.1 ENSMUST00000026239.2 ENSMUST00000026239.3 ENSMUST00000026239.4 ENSMUST00000026239.5 ENSMUST00000026239.6 NM_020032 Polk Poll Q9CTJ1 Q9QXE2 uc008hrc.1 uc008hrc.2 uc008hrc.3 uc008hrc.4 DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Interacts with PCNA. Interacts with PAXX; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end- filling activity of POLL. Interacts with XRCC4; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end- filling activity of POLL. Interacts with NHEJ1/XLF; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end- filling activity of POLL. Nucleus Belongs to the DNA polymerase type-X family. double-strand break repair via homologous recombination DNA binding DNA-directed DNA polymerase activity nucleus DNA replication DNA repair base-excision repair base-excision repair, gap-filling nucleotide-excision repair double-strand break repair via nonhomologous end joining cellular response to DNA damage stimulus transferase activity nucleotidyltransferase activity lyase activity DNA polymerase activity metal ion binding 5'-deoxyribose-5-phosphate lyase activity DNA biosynthetic process uc008hrc.1 uc008hrc.2 uc008hrc.3 uc008hrc.4 
ENSMUST00000026243.5 Oga ENSMUST00000026243.5 O-GlcNAcase, transcript variant 2 (from RefSeq NR_151594.2) ENSMUST00000026243.1 ENSMUST00000026243.2 ENSMUST00000026243.3 ENSMUST00000026243.4 Hexc Kiaa0679 Mgea5 NR_151594 OGA_MOUSE Oga Q3ULY7 Q6ZQ71 Q8BK05 Q8BTT2 Q8CFX2 Q9CSJ4 Q9CUR7 Q9EQQ9 uc008hrn.1 uc008hrn.2 uc008hrn.3 uc008hrn.4 Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha- GlcNAc (in vitro) (PubMed:16517082). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (By similarity). Reaction=3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine; Xref=Rhea:RHEA:48876, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12251, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:90838, ChEBI:CHEBI:506227; EC=3.2.1.169; Evidence=; Reaction=3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine; Xref=Rhea:RHEA:48892, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:12252, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:90840, ChEBI:CHEBI:506227; EC=3.2.1.169; Evidence=; Kinetic parameters: KM=0.49 mM for pNP-GlcNAc ; pH dependence: Optimum pH is 6.5-7. ; Monomer (By similarity). Interacts with CLOCK (PubMed:23395175). Q9EQQ9; P62806: H4c1; NbExp=2; IntAct=EBI-8321615, EBI-299632; Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9EQQ9-1; Sequence=Displayed; Name=2; IsoId=Q9EQQ9-2; Sequence=VSP_020870, VSP_020872; Name=3; IsoId=Q9EQQ9-3; Sequence=VSP_020871; Expressed throughout development from blastocyst stage to embryonic day 16.5. Expression in the liver oscillates in a circadian manner with peak levels at CT8-CT12. Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity. Belongs to the glycosyl hydrolase 84 family. Was initially identified as a bi-functional protein that has an N-terminal domain with O-GlcNAcase activity and a C-terminal domain with histone acetyltransferase activity (PubMed:16356930). The histone acetyltransferase activity was detected only when the protein was expressed in mammalian cells, but not when expressed in bacterial cells, suggesting that the histone acetyltransferase activity might be due to the presence of a contaminant. Characterization of the human protein shows that this protein does not bind acetyl-CoA and therefore cannot have acetyltransferase activity. Sequence=AAH41109.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC97998.1; Type=Erroneous initiation; Evidence=; Sequence=BAE26311.1; Type=Erroneous initiation; Evidence=; histone acetyltransferase activity protein binding nucleus cytoplasm mitochondrion cytosol N-acetylglucosamine metabolic process protein deglycosylation protein targeting to membrane metabolic process glycoprotein metabolic process positive regulation of calcium ion transport into cytosol negative regulation of cardiac muscle adaptation beta-N-acetylglucosaminidase activity histone acetylation hydrolase activity hydrolase activity, acting on glycosyl bonds positive regulation of cell killing positive regulation of insulin secretion positive regulation of protein complex disassembly positive regulation of proteolysis dATP metabolic process positive regulation of glucose import positive regulation of DNA metabolic process positive regulation of mitochondrial depolarization positive regulation of calcium ion transport negative regulation of protein glycosylation positive regulation of growth hormone secretion necrotic cell death uc008hrn.1 uc008hrn.2 uc008hrn.3 uc008hrn.4 
ENSMUST00000026254.14 Gbf1 ENSMUST00000026254.14 golgi-specific brefeldin A-resistance factor 1 (from RefSeq NM_178930.3) ENSMUST00000026254.1 ENSMUST00000026254.10 ENSMUST00000026254.11 ENSMUST00000026254.12 ENSMUST00000026254.13 ENSMUST00000026254.2 ENSMUST00000026254.3 ENSMUST00000026254.4 ENSMUST00000026254.5 ENSMUST00000026254.6 ENSMUST00000026254.7 ENSMUST00000026254.8 ENSMUST00000026254.9 GBF1_MOUSE Gbf1 NM_178930 Q6DFZ1 uc008hsp.1 uc008hsp.2 uc008hsp.3 Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (By similarity). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin- dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (By similarity). Has GEF activity towards ARF1 (By similarity). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (By similarity). Required for the assembly of the Golgi apparatus (By similarity). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (By similarity). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (By similarity). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (By similarity). Plays a role in maintaining mitochondrial morphology (By similarity). Can form homodimers and probably homotetramers (By similarity). Interacts with COPG1; the interaction is independent on ARF1 activation (By similarity). Interacts with ARF1, ARF3, ARF4 and ARF5 (By similarity). Interacts with RAB1B (GTP-bound form); required for GBF1 membrane association (By similarity). Interacts with GGA1, GGA2 and GGA3 (By similarity). Interacts with USO1 (By similarity). Interacts (via SEC7 domain) with PNPLA2 (via C-terminus); the interaction is direct (By similarity). Interacts with ARMH3 (By similarity). Q6DFZ1; P41542: Uso1; Xeno; NbExp=3; IntAct=EBI-761491, EBI-4423297; Golgi apparatus, cis-Golgi network Endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus, trans-Golgi network Golgi apparatus Cytoplasm Lipid droplet Membrane; Peripheral membrane protein Note=Cycles rapidly on and off early Golgi membranes. Stabilized on membranes when complexed with ARF1-GDP and is released from both ARF1 and membranes after it catalyzes GDP displacement and ARF1 binds GTP. Continuous cycles of recruitment and dissociation of GBF1 to membranes are required for sustained ARF activation and COP I recruitment (By similarity). Expressed in brain, spinal cord, and gastrocnemius muscle at postnatal days P10, P21, and P28 (at protein level) (PubMed:32937143). Expression decreases in neuronal tissues from postnatal day P10 to P28 (at protein level) (PubMed:32937143). The DCB (dimerization and cyclophilin-binding) and HUS (homology upstream of Sec7) domains are necessary for dimerization. The DCB domain is proposed to support constitutive homodimerization; the HUS domain interacts with the DCB domain which may occur intramolecular or intermolecular (By similarity). Golgi membrane cell activation involved in immune response ARF guanyl-nucleotide exchange factor activity protein binding phosphatidylinositol-3,4,5-trisphosphate binding mitochondrion peroxisome endoplasmic reticulum lumen endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus Golgi stack cis-Golgi network trans-Golgi network cytosol retrograde vesicle-mediated transport, Golgi to ER Golgi to endosome transport Golgi organization regulation of mitotic cell cycle neutrophil chemotaxis cell leading edge regulation of ARF protein signal transduction protein localization to Golgi apparatus retrograde transport, endosome to Golgi COPI coating of Golgi vesicle establishment of monopolar cell polarity protein localization to endoplasmic reticulum exit site phosphatidylinositol-3,5-bisphosphate binding Golgi disassembly endoplasmic reticulum-Golgi intermediate compartment organization cellular response to virus reactive oxygen species biosynthetic process protein localization to endoplasmic reticulum tubular network regulation of protein localization to cell surface uc008hsp.1 uc008hsp.2 uc008hsp.3 
ENSMUST00000026256.9 Fbxl15 ENSMUST00000026256.9 F-box and leucine-rich repeat protein 15, transcript variant 1 (from RefSeq NM_133694.2) ENSMUST00000026256.1 ENSMUST00000026256.2 ENSMUST00000026256.3 ENSMUST00000026256.4 ENSMUST00000026256.5 ENSMUST00000026256.6 ENSMUST00000026256.7 ENSMUST00000026256.8 FXL15_MOUSE Fbxo37 NM_133694 Q3T9R4 Q91W61 uc008hte.1 uc008hte.2 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Protein modification; protein ubiquitination. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15. Cytoplasm Expressed in heart, liver, spleen, bone, muscle, brain and kidney (at protein level). Belongs to the FBXL15 family. Sequence=AK003032; Type=Frameshift; Evidence=; G2/M transition of mitotic cell cycle ubiquitin-protein transferase activity cytoplasm ubiquitin-dependent protein catabolic process dorsal/ventral pattern formation protein ubiquitination SCF ubiquitin ligase complex bone mineralization positive regulation of BMP signaling pathway SCF-dependent proteasomal ubiquitin-dependent protein catabolic process uc008hte.1 uc008hte.2 
ENSMUST00000026259.16 Pitx3 ENSMUST00000026259.16 paired-like homeodomain transcription factor 3 (from RefSeq NM_008852.4) ENSMUST00000026259.1 ENSMUST00000026259.10 ENSMUST00000026259.11 ENSMUST00000026259.12 ENSMUST00000026259.13 ENSMUST00000026259.14 ENSMUST00000026259.15 ENSMUST00000026259.2 ENSMUST00000026259.3 ENSMUST00000026259.4 ENSMUST00000026259.5 ENSMUST00000026259.6 ENSMUST00000026259.7 ENSMUST00000026259.8 ENSMUST00000026259.9 NM_008852 O35160 PITX3_MOUSE Q0VB03 uc008hsl.1 uc008hsl.2 uc008hsl.3 uc008hsl.4 Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle. Interacts with SFPQ. Nucleus Highly expressed in developing eye lens. Expression is restricted to the substantia nigra and ventral tegmental area in the midbrain. First visible in 10.5 dpc embryos where expression is confined to the lens vesicles. Between 11.5 dpc and 12.5 dpc, expressed in both the lens epithelium and differentiating primary fiber cells. In the late fetal stage after the lens is formed, primarily found in the lens epithelium and the lens equator region where lens epithelial cells exit from the cell cycle and differentiate into fiber cells (at protein level). First expressed in the eye at 10 dpc embryos. Throughout eye development, expressed in the lens placode and forming lens pit. From 12 dpc, also detected in the midbrain region, tongue, incisor primordia, condensing mesenchyme around the sternum and vertebrae and in the head muscles. Note=Mutations in Pitx3 appear to be the cause of the aphakia (ak) phenotype, a recessive homozygous disease characterized by small eyes and closed eyelids. Mice show loss of nascent substantia nigra dopaminergic neurons at the beginning of their final differentiation and a loss of tyrosine hydroxylase (TH) expression specifically in the substantia nigra neurons. Belongs to the paired homeobox family. Bicoid subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding lens development in camera-type eye lens morphogenesis in camera-type eye DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated multicellular organism development aging locomotory behavior anatomical structure morphogenesis regulation of gene expression negative regulation of gliogenesis midbrain development response to immobilization stress response to cocaine neuronal cell body response to morphine positive regulation of neuron apoptotic process sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter neuron development negative regulation of neurogenesis lens fiber cell differentiation dopaminergic neuron differentiation response to methamphetamine hydrochloride positive regulation of cell proliferation in midbrain cellular response to glial cell derived neurotrophic factor uc008hsl.1 uc008hsl.2 uc008hsl.3 uc008hsl.4 
ENSMUST00000026262.8 Hexa ENSMUST00000026262.8 hexosaminidase A, transcript variant 3 (from RefSeq NR_177070.1) ENSMUST00000026262.1 ENSMUST00000026262.2 ENSMUST00000026262.3 ENSMUST00000026262.4 ENSMUST00000026262.5 ENSMUST00000026262.6 ENSMUST00000026262.7 HEXA_MOUSE Hexa NR_177070 P29416 Q64246 Q91XG3 uc009pxw.1 uc009pxw.2 uc009pxw.3 Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52; Evidence=; Reaction=H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3- sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = a beta-D- 3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N- acetyl-beta-D-galactosamine; Xref=Rhea:RHEA:48276, ChEBI:CHEBI:15377, ChEBI:CHEBI:28497, ChEBI:CHEBI:90163, ChEBI:CHEBI:90164; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48277; Evidence=; Reaction=a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine; Xref=Rhea:RHEA:47940, ChEBI:CHEBI:15377, ChEBI:CHEBI:28497, ChEBI:CHEBI:60065, ChEBI:CHEBI:71502; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47941; Evidence=; Reaction=a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D- galactosamine; Xref=Rhea:RHEA:47968, ChEBI:CHEBI:15377, ChEBI:CHEBI:28497, ChEBI:CHEBI:79210, ChEBI:CHEBI:79218; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47969; Evidence=; Reaction=beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4- sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O = alpha- L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D- GalNAc-4-sulfate + N-acetyl-D-galactosamine; Xref=Rhea:RHEA:64372, ChEBI:CHEBI:15377, ChEBI:CHEBI:28037, ChEBI:CHEBI:152565, ChEBI:CHEBI:152566; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64373; Evidence=; Reaction=H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L- iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine = alpha-L-iduronyl- (1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6- sulfogalactosamine; Xref=Rhea:RHEA:64384, ChEBI:CHEBI:15377, ChEBI:CHEBI:152567, ChEBI:CHEBI:152568, ChEBI:CHEBI:153064; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64385; Evidence=; Addition of GM2A stimulates the hydrolysis of sulfated glycosphingolipid SM2 and the ganglioside GM2. There are 3 beta-hexosaminidase isozymes: isozyme A (hexosaminidase A) is an heterodimer composed of one subunit alpha and one subunit beta (chain A and B); isozyme B (hexosaminidase B) is an homodimer of two beta subunits (two chains A and B); isozyme S (hexosaminidase S) is a homodimer of two alpha subunits. The composition of the dimer (isozyme A versus isozyme S) has a significant effect on the substrate specificity of the alpha subunit active site. Lysosome. Ubiquitous. Most abundant in testis, adrenal, epididymis and heart. Low levels seen in the liver. Belongs to the glycosyl hydrolase 20 family. skeletal system development hydrolase activity, hydrolyzing O-glycosyl compounds beta-N-acetylhexosaminidase activity lysosome carbohydrate metabolic process glycosaminoglycan biosynthetic process ganglioside catabolic process lysosome organization sensory perception of sound locomotory behavior adult walking behavior metabolic process acetylglucosaminyltransferase activity membrane hydrolase activity hydrolase activity, acting on glycosyl bonds lipid storage sexual reproduction glycosaminoglycan metabolic process myelination azurophil granule protein heterodimerization activity cell morphogenesis involved in neuron differentiation neuromuscular process controlling posture neuromuscular process controlling balance SMAD protein signal transduction uc009pxw.1 uc009pxw.2 uc009pxw.3 
ENSMUST00000026265.8 Bbs4 ENSMUST00000026265.8 Bardet-Biedl syndrome 4, transcript variant 3 (from RefSeq NR_153195.1) BBS4_MOUSE ENSMUST00000026265.1 ENSMUST00000026265.2 ENSMUST00000026265.3 ENSMUST00000026265.4 ENSMUST00000026265.5 ENSMUST00000026265.6 ENSMUST00000026265.7 NR_153195 Q3UYF0 Q562E1 Q5EBJ7 Q8C1Z7 Q8CA57 uc009pxr.1 uc009pxr.2 uc009pxr.3 uc009pxr.4 The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome (By similarity). Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts with PCM1 and DCTN1. Interacts with DC28B. Interacts with ALDOB and C2CD3. Interacts with PKD1 (By similarity). Interacts with CEP290 (By similarity). Interacts with DLEC1 (By similarity). Q8C1Z7; Q3V3N7: Bbs1; NbExp=5; IntAct=EBI-2892887, EBI-2892836; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cell projection, cilium membrane Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cell projection, cilium, flagellum Cell projection, cilium Note=Localizes to the pericentriolar material. Centrosomal localization requires dynein (By similarity). Localizes to the connecting cilium of photoreceptor cells (PubMed:23943788). Expressed in the hippocampus and dentate gyrus, the columnar epithelial cells of bronchioles, the olfactory epithelium and the inner segment and outer nuclear layer of the retina. Expressed in testis. Expressed in the pericardium of the developing embryo and in the epidermal layer surrounding the digits. Males are sterile due to a loss of sperm flagella. In mice obesity is associated with hyperleptinemia and resistance to the anorectic and weight-reducing effects of leptin. Although mice are resistant to the metabolic actions of leptin, animals remain responsive to the effects of leptin on renal sympathetic nerve activity and arterial pressure and developed hypertension. BBS mice have decreased hypothalamic expression of proopiomelanocortin (POMC). BBS genes play an important role in maintaining leptin sensitivity in POMC neurons. Belongs to the BBS4 family. microtubule cytoskeleton organization pericentriolar material mitotic cytokinesis RNA polymerase II repressing transcription factor binding photoreceptor outer segment neuron migration neural tube closure retina homeostasis photoreceptor inner segment negative regulation of systemic arterial blood pressure microtubule motor activity protein binding nucleus cytoplasm centrosome centriole microtubule organizing center cytosol cytoskeleton plasma membrane cilium centrosome cycle spermatid development sensory perception of smell protein localization negative regulation of gene expression protein transport membrane dendrite development regulation of lipid metabolic process ventricular system development striatum development hippocampus development cerebral cortex development cell projection organization adult behavior negative regulation of actin filament polymerization motile cilium photoreceptor connecting cilium regulation of cytokinesis leptin-mediated signaling pathway protein localization to organelle negative regulation of GTPase activity centriolar satellite dynactin binding microtubule anchoring at centrosome BBSome social behavior photoreceptor cell outer segment organization ciliary transition zone ciliary basal body negative regulation of appetite by leptin-mediated signaling pathway positive regulation of multicellular organism growth cell projection alpha-tubulin binding response to leptin fat cell differentiation photoreceptor cell maintenance positive regulation of cilium assembly retinal rod cell development beta-tubulin binding brain morphogenesis maintenance of protein location in nucleus regulation of stress fiber assembly ciliary membrane cilium assembly regulation of cilium beat frequency involved in ciliary motility face development fat pad development protein localization to cilium protein localization to centrosome non-motile cilium regulation of non-motile cilium assembly protein localization to photoreceptor outer segment non-motile cilium assembly uc009pxr.1 uc009pxr.2 uc009pxr.3 uc009pxr.4 
ENSMUST00000026267.16 Parp6 ENSMUST00000026267.16 poly (ADP-ribose) polymerase family, member 6, transcript variant 1 (from RefSeq NM_001205239.1) ENSMUST00000026267.1 ENSMUST00000026267.10 ENSMUST00000026267.11 ENSMUST00000026267.12 ENSMUST00000026267.13 ENSMUST00000026267.14 ENSMUST00000026267.15 ENSMUST00000026267.2 ENSMUST00000026267.3 ENSMUST00000026267.4 ENSMUST00000026267.5 ENSMUST00000026267.6 ENSMUST00000026267.7 ENSMUST00000026267.8 ENSMUST00000026267.9 G5E856 G5E856_MOUSE NM_001205239 Parp6 uc009pyd.1 uc009pyd.2 uc009pyd.3 uc009pyd.4 Belongs to the ARTD/PARP family. NAD+ ADP-ribosyltransferase activity transferase activity transferase activity, transferring glycosyl groups positive regulation of dendrite morphogenesis protein auto-ADP-ribosylation protein ADP-ribosylase activity uc009pyd.1 uc009pyd.2 uc009pyd.3 uc009pyd.4 
ENSMUST00000026269.4 Limd1 ENSMUST00000026269.4 LIM domains containing 1, transcript variant 1 (from RefSeq NM_013860.3) ENSMUST00000026269.1 ENSMUST00000026269.2 ENSMUST00000026269.3 LIMD1_MOUSE NM_013860 Q8C8G4 Q9CW55 Q9QXD8 uc009sgf.1 uc009sgf.2 uc009sgf.3 uc009sgf.4 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. Interacts with SQSTM1 and RB1. Interacts with EIF4E, AGO1, AGO2, DCP2, DDX6, LATS1, LATS2, EGLN1/PHD2, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM zinc-binding 2) with VHL. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2 (By similarity). Interacts (via LIM domains) with SNAI1 (via SNAG domain), SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain). Found in a complex with TRAF6, PRKCZ and SQSTM1. Interacts (via LIM domains) with TRAF6. Cytoplasm Nucleus Cytoplasm, P-body Cell junction, adherens junction Cell junction, focal adhesion Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions (By similarity). Ubiquitous. Up-regulated during osteoclast differentiation. Phosphorylated during mitosis. Belongs to the zyxin/ajuba family. P-body response to hypoxia osteoblast development transcription corepressor activity protein binding nucleus transcription factor complex cytoplasm plasma membrane cell-cell junction adherens junction focal adhesion regulation of transcription, DNA-templated cytoskeleton organization regulation of cell shape phosphorylation RISC complex cell migration cell junction gene silencing by RNA cytoplasmic mRNA processing body assembly gene silencing by miRNA negative regulation of hippo signaling negative regulation of osteoblast differentiation negative regulation of transcription, DNA-templated metal ion binding negative regulation of canonical Wnt signaling pathway positive regulation of gene silencing by miRNA uc009sgf.1 uc009sgf.2 uc009sgf.3 uc009sgf.4 
ENSMUST00000026270.9 Sacm1l ENSMUST00000026270.9 SAC1 suppressor of actin mutations 1-like (yeast), transcript variant 1 (from RefSeq NM_030692.5) ENSMUST00000026270.1 ENSMUST00000026270.2 ENSMUST00000026270.3 ENSMUST00000026270.4 ENSMUST00000026270.5 ENSMUST00000026270.6 ENSMUST00000026270.7 ENSMUST00000026270.8 Kiaa0851 NM_030692 Q80TQ1 Q99K33 Q9EP69 SAC1_MOUSE Sac1 uc009sgh.1 uc009sgh.2 uc009sgh.3 This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Dec 2017]. Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:32931550). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (By similarity). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3- phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12317; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4- phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:55652, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58178; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55653; Evidence=; Interacts with TMEM39A (By similarity). Interacts with SEC23A and SEC24A; this interaction is reduced in the absence of TMEM39A (By similarity). Interacts with PLEKHA3 and VAPA and/or VAPB to form a ternary complex (By similarity). Interacts with SACM1L; the interaction regulates SACM1L phosphatidylinositol-3-phosphatase activity and translocation to endoplasmic reticulum/trans Golgi network in a malonyl-CoA dependent manner (PubMed:32931550). Q9EP69; A0A0F6B5H5: pipB2; Xeno; NbExp=3; IntAct=EBI-6908224, EBI-27033185; Q9EP69; A0A0F6B423: sseL; Xeno; NbExp=4; IntAct=EBI-6908224, EBI-13953897; Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Note=Trafficking between the ER and Golgi is regulated by nutrient status and by TMEM39A. Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) in the presence of phosphatidylinositol-4,5-bisphosphate. Detected in brain, lung, liver and kidney, and at lower levels in spleen and skeletal muscle. Sequence=BAC65672.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; phosphatidylinositol-3-phosphatase activity endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus biological_process membrane integral component of membrane hydrolase activity phosphatase activity integral component of endoplasmic reticulum membrane AMPA glutamate receptor complex phosphatidylinositol bisphosphate phosphatase activity phosphoric ester hydrolase activity phosphatidylinositol-4-phosphate phosphatase activity phosphatidylinositol dephosphorylation uc009sgh.1 uc009sgh.2 uc009sgh.3 
ENSMUST00000026273.11 Slc6a20b ENSMUST00000026273.11 solute carrier family 6 (neurotransmitter transporter), member 20B, transcript variant 1 (from RefSeq NM_011731.4) A0A803YV45 A0A803YV45_MOUSE ENSMUST00000026273.1 ENSMUST00000026273.10 ENSMUST00000026273.2 ENSMUST00000026273.3 ENSMUST00000026273.4 ENSMUST00000026273.5 ENSMUST00000026273.6 ENSMUST00000026273.7 ENSMUST00000026273.8 ENSMUST00000026273.9 NM_011731 Slc6a20b mCG_15852 uc009sgi.1 uc009sgi.2 uc009sgi.3 uc009sgi.4 Membrane ; Multi- pass membrane protein Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. uc009sgi.1 uc009sgi.2 uc009sgi.3 uc009sgi.4 
ENSMUST00000026274.14 Lztfl1 ENSMUST00000026274.14 leucine zipper transcription factor-like 1, transcript variant 1 (from RefSeq NM_033322.3) ENSMUST00000026274.1 ENSMUST00000026274.10 ENSMUST00000026274.11 ENSMUST00000026274.12 ENSMUST00000026274.13 ENSMUST00000026274.2 ENSMUST00000026274.3 ENSMUST00000026274.4 ENSMUST00000026274.5 ENSMUST00000026274.6 ENSMUST00000026274.7 ENSMUST00000026274.8 ENSMUST00000026274.9 LZTL1_MOUSE NM_033322 Q8BRX8 Q8CDS2 Q9JHQ5 uc009sgm.1 uc009sgm.2 uc009sgm.3 Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function. Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. Cytoplasm Highly expressed in testis. Expressed in brain, cerebellum, eye, heart, kidney, liver, lung and trachea. In small intestine, graded expression along the crypt-villus axis with high levels in the villus apex and lower levels in the crypt stem cells (at protein level). Not expressed in skeletal muscle and white adipose tissue. In hippocampus, up-regulated by exercise training. Belongs to the LZTFL1 family. Sequence=BAC26556.1; Type=Frameshift; Evidence=; protein binding cytoplasm cytosol identical protein binding macromolecular complex binding negative regulation of protein localization to cilium negative regulation of protein localization to ciliary membrane uc009sgm.1 uc009sgm.2 uc009sgm.3 
ENSMUST00000026288.5 Ribc1 ENSMUST00000026288.5 RIB43A domain with coiled-coils 1 (from RefSeq NM_025660.3) ENSMUST00000026288.1 ENSMUST00000026288.2 ENSMUST00000026288.3 ENSMUST00000026288.4 NM_025660 Q9CS97 Q9D0B8 RIBC1_MOUSE uc009upv.1 uc009upv.2 uc009upv.3 Belongs to the RIB43A family. molecular_function cellular_component biological_process uc009upv.1 uc009upv.2 uc009upv.3 
ENSMUST00000026289.10 Hsd17b10 ENSMUST00000026289.10 hydroxysteroid (17-beta) dehydrogenase 10 (from RefSeq NM_016763.2) ENSMUST00000026289.1 ENSMUST00000026289.2 ENSMUST00000026289.3 ENSMUST00000026289.4 ENSMUST00000026289.5 ENSMUST00000026289.6 ENSMUST00000026289.7 ENSMUST00000026289.8 ENSMUST00000026289.9 Hadh2 Hsd17b10 Hsd17b10/Schad NM_016763 Q99N15 Q99N15_MOUSE uc009upu.1 uc009upu.2 uc009upu.3 Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24613; Evidence=; Belongs to the short-chain dehydrogenases/reductases (SDR) family. tRNA binding 3-hydroxyacyl-CoA dehydrogenase activity mitochondrion mitochondrion organization oxidoreductase activity testosterone dehydrogenase [NAD(P)] activity mitochondrial ribonuclease P complex protein homotetramerization oxidation-reduction process mitochondrial tRNA methylation mitochondrial tRNA 5'-end processing mitochondrial tRNA 3'-end processing uc009upu.1 uc009upu.2 uc009upu.3 
ENSMUST00000026292.15 Huwe1 ENSMUST00000026292.15 HECT, UBA and WWE domain containing 1 (from RefSeq NM_021523.5) A2AFQ0 A2AFQ0_MOUSE ENSMUST00000026292.1 ENSMUST00000026292.10 ENSMUST00000026292.11 ENSMUST00000026292.12 ENSMUST00000026292.13 ENSMUST00000026292.14 ENSMUST00000026292.2 ENSMUST00000026292.3 ENSMUST00000026292.4 ENSMUST00000026292.5 ENSMUST00000026292.6 ENSMUST00000026292.7 ENSMUST00000026292.8 ENSMUST00000026292.9 Huwe1 NM_021523 uc009upn.1 uc009upn.2 uc009upn.3 uc009upn.4 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence=; Protein modification; protein ubiquitination. Belongs to the UPL family. TOM1/PTR1 subfamily. protein polyubiquitination ubiquitin-protein transferase activity nucleoplasm cytoplasm cytosol base-excision repair protein monoubiquitination histone ubiquitination transferase activity positive regulation of protein ubiquitination circadian regulation of gene expression uc009upn.1 uc009upn.2 uc009upn.3 uc009upn.4 
ENSMUST00000026296.8 Fgd1 ENSMUST00000026296.8 FYVE, RhoGEF and PH domain containing 1 (from RefSeq NM_008001.4) ENSMUST00000026296.1 ENSMUST00000026296.2 ENSMUST00000026296.3 ENSMUST00000026296.4 ENSMUST00000026296.5 ENSMUST00000026296.6 ENSMUST00000026296.7 FGD1_MOUSE NM_008001 P52734 Q921L2 uc009uow.1 uc009uow.2 uc009uow.3 uc009uow.4 This gene encodes a member of family of Rho-specific guanine nucleotide exchange factors. Rho-specific guanine nucleotide exchange factors catalyze the exchange of GDP for GTP and activate small GTPases, which function as molecular switches in signaling. This protein specifically binds cell division cycle 42, a Rho (Ras homology) GTPase. Investigations in mouse suggest that this protein is important for skeletal mineralization and for regulating the actin cytoskeleton. In humans, mutations in this gene are associated with faciogenital dysplasia, also known as Aarskog-Scott syndrome. [provided by RefSeq, Mar 2014]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK148151.1, BC011462.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Interacts with DBNL/ABP1 and CTTN. Binds CDC42 (By similarity). May interact with CCPG1. Cytoplasm Cell projection, lamellipodium Cell projection, ruffle Cytoplasm, cytoskeleton Note=Associated with membrane ruffles and lamellipodia. The DH domain is involved in interaction with CCPG1. ruffle guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding cytoplasm Golgi apparatus cytoskeleton cytoskeleton organization regulation of cell shape lamellipodium actin cytoskeleton organization small GTPase binding regulation of Rho protein signal transduction cell projection regulation of GTPase activity filopodium assembly metal ion binding uc009uow.1 uc009uow.2 uc009uow.3 uc009uow.4 
ENSMUST00000026315.8 Dnase1l3 ENSMUST00000026315.8 deoxyribonuclease 1-like 3 (from RefSeq NM_007870.3) DNSL3_MOUSE Dnase1l3 ENSMUST00000026315.1 ENSMUST00000026315.2 ENSMUST00000026315.3 ENSMUST00000026315.4 ENSMUST00000026315.5 ENSMUST00000026315.6 ENSMUST00000026315.7 NM_007870 O55070 Q91X38 uc007sem.1 uc007sem.2 uc007sem.3 uc007sem.4 Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA (PubMed:15796714, PubMed:19154352, PubMed:12095301). Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self- reactive B cells (PubMed:12050166, PubMed:15167901, PubMed:17218958, PubMed:24312463). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (PubMed:15796714, PubMed:27293190). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (PubMed:29191910). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:29191910). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (PubMed:29191910). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by zinc. Inhibited by heparin and proteolysis by plasmin. Nucleus doplasmic reticulum Secreted Note=Contradictory reports exist about the subcellular localization under normal physiological conditions. Shown to translocate to rough endoplasmic reticulum and to be transported through the entire secretory pathway for secretion. However, under conditions of cell death, may diffuse and/or be actively transported to the nucleus. Expressed at high levels in liver, spleen and testes. Expressed at lower levels in heart, lungs, skeletal muscle and kidney. Not expressed in brain. Predominantly expressed in macrophages; at protein level. Secreted by mononuclear phagocytes. Expression is first detected at embryonic day 11, and higher amounts were detected at days 15 and 17. Poly-ADP-ribosylated by PARP1. ADP-ribosylation negatively regulates enzymatic activity during apoptosis. Mice develop symptoms of the autoimmune disease systemic lupus erythematosus, characterized by high titers of anti- nuclear autoantibodies (ANA) directed against nucleosomes and double- stranded DNA, the deposition of immune complexes in glomeruli and full- blown glomerulonephritis (PubMed:27293190). Mice lacking both Dnase1 and Dnase1l3 show vascular occlusions following bacterial infection: defects are caused by the formation of intravascular neutrophil extracellular traps (NETs) clots that obstruct blood vessels and cause organ damage (PubMed:29191910). Belongs to the DNase I family. DNA catabolic process, endonucleolytic neutrophil activation involved in immune response regulation of acute inflammatory response DNA binding nuclease activity endonuclease activity endodeoxyribonuclease activity deoxyribonuclease I activity deoxyribonuclease activity extracellular region nucleus endoplasmic reticulum DNA catabolic process apoptotic DNA fragmentation apoptotic process programmed cell death involved in cell development programmed cell death hydrolase activity regulation of neutrophil mediated cytotoxicity uc007sem.1 uc007sem.2 uc007sem.3 uc007sem.4 
ENSMUST00000026318.15 Sat1 ENSMUST00000026318.15 spermidine/spermine N1-acetyl transferase 1, transcript variant 1 (from RefSeq NM_009121.5) ENSMUST00000026318.1 ENSMUST00000026318.10 ENSMUST00000026318.11 ENSMUST00000026318.12 ENSMUST00000026318.13 ENSMUST00000026318.14 ENSMUST00000026318.2 ENSMUST00000026318.3 ENSMUST00000026318.4 ENSMUST00000026318.5 ENSMUST00000026318.6 ENSMUST00000026318.7 ENSMUST00000026318.8 ENSMUST00000026318.9 NM_009121 P48026 Q3U444 SAT1_MOUSE Sat Sat1 uc009urq.1 uc009urq.2 uc009urq.3 uc009urq.4 Enzyme which catalyzes the acetylation of polyamines (PubMed:18690703). Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine (By similarity). This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines (By similarity). Also involved in the regulation of polyamine transport out of cells (By similarity). Also acts on 1,3- diaminopropane and 1,5-diaminopentane (By similarity). Reaction=acetyl-CoA + an alkane-alpha,omega-diamine = an N- acetylalkane-alpha,omega-diamine + CoA + H(+); Xref=Rhea:RHEA:11116, Rhea:RHEA-COMP:9766, Rhea:RHEA-COMP:9767, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:70977, ChEBI:CHEBI:70988; EC=2.3.1.57; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11117; Evidence=; Reaction=acetyl-CoA + spermidine = CoA + H(+) + N(1)-acetylspermidine; Xref=Rhea:RHEA:28150, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57834, ChEBI:CHEBI:58324; EC=2.3.1.57; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28151; Evidence=; Reaction=acetyl-CoA + spermine = CoA + H(+) + N(1)-acetylspermine; Xref=Rhea:RHEA:33099, ChEBI:CHEBI:15378, ChEBI:CHEBI:45725, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58101; EC=2.3.1.57; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33100; Evidence=; pH dependence: Optimum pH is 8.5-9.5. ; Amine and polyamine degradation; putrescine degradation; N- acetylputrescine from putrescine: step 1/1. Homodimer. Cytoplasm, cytosol Belongs to the acetyltransferase family. angiogenesis diamine N-acetyltransferase activity cytoplasm cytosol polyamine metabolic process polyamine catabolic process N-acetyltransferase activity putrescine catabolic process transferase activity transferase activity, transferring acyl groups spermidine binding spermidine acetylation regulation of cell proliferation identical protein binding spermine catabolic process uc009urq.1 uc009urq.2 uc009urq.3 uc009urq.4 
ENSMUST00000026322.9 Polr3a ENSMUST00000026322.9 polymerase (RNA) III (DNA directed) polypeptide A (from RefSeq NM_001081247.2) B2RXC6 B2RXC6_MOUSE ENSMUST00000026322.1 ENSMUST00000026322.2 ENSMUST00000026322.3 ENSMUST00000026322.4 ENSMUST00000026322.5 ENSMUST00000026322.6 ENSMUST00000026322.7 ENSMUST00000026322.8 NM_001081247 Polr3a uc007sqy.1 uc007sqy.2 uc007sqy.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA- COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.6; Evidence= Nucleus Belongs to the RNA polymerase beta' chain family. DNA binding chromatin binding DNA-directed 5'-3' RNA polymerase activity nucleoplasm DNA-directed RNA polymerase III complex transcription, DNA-templated transcription from RNA polymerase III promoter transferase activity nucleotidyltransferase activity positive regulation of interferon-beta production innate immune response RNA polymerase III activity uc007sqy.1 uc007sqy.2 uc007sqy.3 
ENSMUST00000026324.10 Acot9 ENSMUST00000026324.10 acyl-CoA thioesterase 9, transcript variant 1 (from RefSeq NM_019736.4) ACOT9_MOUSE Acate2 ENSMUST00000026324.1 ENSMUST00000026324.2 ENSMUST00000026324.3 ENSMUST00000026324.4 ENSMUST00000026324.5 ENSMUST00000026324.6 ENSMUST00000026324.7 ENSMUST00000026324.8 ENSMUST00000026324.9 NM_019736 Q545G7 Q9R0X4 Q9WTJ0 Q9WUZ8 uc009urs.1 uc009urs.2 uc009urs.3 Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs. Interacts with NYAP1, NYAP2 and MYO16. Mitochondrion Belongs to the acyl coenzyme A hydrolase family. acetyl-CoA hydrolase activity protein binding mitochondrion acyl-CoA metabolic process hydrolase activity acyl-CoA hydrolase activity carboxylic ester hydrolase activity uc009urs.1 uc009urs.2 uc009urs.3 
ENSMUST00000026325.2 4933436I01Rik ENSMUST00000026325.2 RIKEN cDNA 4933436I01 gene (from RefSeq NM_025763.1) 4933436I01Rik ENSMUST00000026325.1 NM_025763 Q9D3T1 Q9D3T1_MOUSE uc009tis.1 uc009tis.2 molecular_function cellular_component biological_process uc009tis.1 uc009tis.2 
ENSMUST00000026328.11 Prdx4 ENSMUST00000026328.11 peroxiredoxin 4, transcript variant 2 (from RefSeq NM_016764.5) B1AZS7 ENSMUST00000026328.1 ENSMUST00000026328.10 ENSMUST00000026328.2 ENSMUST00000026328.3 ENSMUST00000026328.4 ENSMUST00000026328.5 ENSMUST00000026328.6 ENSMUST00000026328.7 ENSMUST00000026328.8 ENSMUST00000026328.9 NM_016764 O08807 PRDX4_MOUSE Q3U8E4 uc009uru.1 uc009uru.2 uc009uru.3 uc009uru.4 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events (PubMed:11229364). Regulates the activation of NF- kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation (By similarity). Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]- disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.24; Evidence=; Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer. O08807; Q8NBS9-1: TXNDC5; Xeno; NbExp=2; IntAct=EBI-494652, EBI-16091651; Cytoplasm Endoplasmic reticulum Note=Not secreted. The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin. Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. peroxidase activity protein binding extracellular space cytoplasm mitochondrion endoplasmic reticulum smooth endoplasmic reticulum cytosol response to oxidative stress spermatogenesis thioredoxin peroxidase activity male gonad development antioxidant activity oxidoreductase activity 4-hydroxyproline metabolic process protein maturation by protein folding extracellular matrix organization hydrogen peroxide catabolic process protein homodimerization activity cell redox homeostasis peroxiredoxin activity oxidation-reduction process reactive oxygen species metabolic process cellular oxidant detoxification negative regulation of male germ cell proliferation uc009uru.1 uc009uru.2 uc009uru.3 uc009uru.4 
ENSMUST00000026357.12 Jph3 ENSMUST00000026357.12 junctophilin 3 (from RefSeq NM_020605.3) ENSMUST00000026357.1 ENSMUST00000026357.10 ENSMUST00000026357.11 ENSMUST00000026357.2 ENSMUST00000026357.3 ENSMUST00000026357.4 ENSMUST00000026357.5 ENSMUST00000026357.6 ENSMUST00000026357.7 ENSMUST00000026357.8 ENSMUST00000026357.9 JPH3_MOUSE Jp3 NM_020605 Q3ZAS3 Q8BNM7 Q9EQZ2 Q9ET77 uc009nrz.1 uc009nrz.2 uc009nrz.3 uc009nrz.4 Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N- terminal part associates with the plasma membrane. Specifically expressed in brain. Highest levels in the olfactory tubercle, caudate putamen, nucleus accumbens, hippocampal formation, piriform cortex and cerebellar cortex. Expressed in disctete neurons sites. In hippocampal formation, expressed in dendrites of hippocampal pyramidal and denate granule cells. In cerebellum, it is highly expressed in Purkinge cells, while it is weakly expressed in granular cells. The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids. Mice are viable and fertile, but have defects in balance/motor coordination tasks. Jph3 and Jph4 double knockout mice exhibit atypical depolarizing responses, irregular cerebellar plasticity due to abolished crosstalk in Purkinje cells. There is hyperphosphorylation of PRKCG and mild impairment of synaptic maturation. Exploratory activity, hippocampal plasticity and memory are impaired and there is abnormal foot-clasping reflex. Belongs to the junctophilin family. Sequence=BAC38666.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane plasma membrane learning memory calcium-release channel activity membrane integral component of membrane junctional membrane complex exploration behavior locomotion regulation of synaptic plasticity regulation of neuronal synaptic plasticity neuromuscular process controlling balance release of sequestered calcium ion into cytosol regulation of ryanodine-sensitive calcium-release channel activity uc009nrz.1 uc009nrz.2 uc009nrz.3 uc009nrz.4 
ENSMUST00000026360.9 Itgb8 ENSMUST00000026360.9 integrin beta 8 (from RefSeq NM_177290.4) ENSMUST00000026360.1 ENSMUST00000026360.2 ENSMUST00000026360.3 ENSMUST00000026360.4 ENSMUST00000026360.5 ENSMUST00000026360.6 ENSMUST00000026360.7 ENSMUST00000026360.8 ITB8_MOUSE Itgb8 NM_177290 Q0VBD0 uc007pik.1 uc007pik.2 uc007pik.3 Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (PubMed:25127859). Required during vasculogenesis (PubMed:12050137, PubMed:16251442). Heterodimer of an alpha and a beta subunit (PubMed:25127859). Beta-8 (ITGB8) associates with alpha-V (ITGAV) to form ITGAV:ITGB8 (PubMed:25127859). ITGAV:ITGB8 interacts with TGFB1 (PubMed:25127859). Cell membrane ; Single-pass type I membrane protein Expressed in endodermal cells surrounding endothelium in the yolk sac and in periventricular cells of the neuroepithelium in the brain. The VWFA domain (or beta I domain) contains two cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS) and the metal ion-dependent adhesion site (MIDAS). Unlike in the other beta integrins, the cation-binding site adjacent MIDAS site (ADMIDAS) in ITGB8 is not functional due to the presence of two Asn residues instead of 2 Asp residues. This domain is also part of the ligand- binding site. Embryonic or perinatal lethality caused profound defects in vascular development (PubMed:12050137). More than half embryos die at midgestation, with evidence of insufficient vascularization of the placenta and yolk sac (PubMed:12050137). Surviving embryos die shortly after birth with extensive intracerebral hemorrhage (PubMed:12050137). Conditional deletion in the neuroepithelium results in bilateral hemorrhage at in neonates caused by endothelial cell abnormalities in the developing cortex (PubMed:16251442). Belongs to the integrin beta chain family. vasculogenesis ganglioside metabolic process receptor binding integrin binding plasma membrane cell adhesion cell-matrix adhesion integrin-mediated signaling pathway integrin complex cell surface positive regulation of gene expression negative regulation of gene expression membrane integral component of membrane cell migration cell adhesion mediated by integrin integrin alphav-beta8 complex signaling receptor activity positive regulation of angiogenesis cartilage development regulation of transforming growth factor beta activation extracellular matrix protein binding uc007pik.1 uc007pik.2 uc007pik.3 
ENSMUST00000026377.9 Padi3 ENSMUST00000026377.9 peptidyl arginine deiminase, type III (from RefSeq NM_011060.4) A2AMU4 ENSMUST00000026377.1 ENSMUST00000026377.2 ENSMUST00000026377.3 ENSMUST00000026377.4 ENSMUST00000026377.5 ENSMUST00000026377.6 ENSMUST00000026377.7 ENSMUST00000026377.8 NM_011060 PADI3_MOUSE Pad3 Pdi3 Q9Z184 uc008vng.1 uc008vng.2 uc008vng.3 Catalyzes the deimination of arginine residues of proteins. Reaction=H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+); Xref=Rhea:RHEA:18089, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:10588, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29965, ChEBI:CHEBI:83397; EC=3.5.3.15; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Cytoplasm Epidermis and hair follicles. No visible phenotype. The skin of 7-week-old null mice appeared normal, but scanning electron microscopy revealed structural alterations in the whiskers and hair coat morphology (PubMed:27866708). Belongs to the protein arginine deiminase family. protein-arginine deiminase activity calcium ion binding nucleus cytoplasm hydrolase activity protein citrullination histone citrullination identical protein binding uc008vng.1 uc008vng.2 uc008vng.3 
ENSMUST00000026378.4 Padi1 ENSMUST00000026378.4 peptidyl arginine deiminase, type I (from RefSeq NM_011059.2) ENSMUST00000026378.1 ENSMUST00000026378.2 ENSMUST00000026378.3 NM_011059 PADI1_MOUSE Pad1 Pdi1 Q9Z185 uc008vnh.1 uc008vnh.2 uc008vnh.3 Catalyzes the deimination of arginine residues of proteins. Reaction=H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+); Xref=Rhea:RHEA:18089, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:10588, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29965, ChEBI:CHEBI:83397; EC=3.5.3.15; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Monomer. Cytoplasm Expressed only in the epidermis and uterus. Expressed during the estrus cycle. Expression is maximum at proestrus and moderate at estrus. Not expressed in diestrus and metaestrus phases. By estrogen. Belongs to the protein arginine deiminase family. protein-arginine deiminase activity calcium ion binding nucleus nucleoplasm cytoplasm cytosol hydrolase activity protein citrullination histone citrullination metal ion binding uc008vnh.1 uc008vnh.2 uc008vnh.3 
ENSMUST00000026381.7 Padi4 ENSMUST00000026381.7 peptidyl arginine deiminase, type IV (from RefSeq NM_011061.2) A2AMU3 ENSMUST00000026381.1 ENSMUST00000026381.2 ENSMUST00000026381.3 ENSMUST00000026381.4 ENSMUST00000026381.5 ENSMUST00000026381.6 NM_011061 PADI4_MOUSE Pad4 Pdi4 Q75WC7 Q9Z183 uc008vne.1 uc008vne.2 uc008vne.3 uc008vne.4 Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed:15339660, PubMed:32528174). Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci) (PubMed:15339660). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance (PubMed:24463520, PubMed:32528174). Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci (PubMed:20733033, PubMed:23650392). Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:20733033, PubMed:32528174). Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription (By similarity). Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 (By similarity). Reaction=H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+); Xref=Rhea:RHEA:18089, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:10588, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29965, ChEBI:CHEBI:83397; EC=3.5.3.15; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 5 Ca(2+) ions per subunit. ; Strongly Inhibited by F-amidine and N-alpha- benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine). These inhibitors are however not specific to PADI4 and also inhibit other members of the family. Cytoplasm Nucleus Cytoplasmic granule Note=Cytoplasmic granules of eosinophils and neutrophils. Expressed in pluripotent embryonic stem and induced pluripotent stem cells but not multipotent neural stem cells. Autocitrullination at Arg-372 and Arg-374 inactivates the enzyme. Mice survive to adulthood and do not display detectable physical abnormality (PubMed:20733033). However, mice were born at a rate lower than predicted by the Mendelian ratio and display defects in innate immune response (PubMed:20733033). Impaired formation of neutrophil extracellular traps (NETs) (PubMed:20733033, PubMed:32528174). Mice are more susceptible to bacterial infection: neutrophils cannot form NETs after stimulation with chemokines or incubation with bacteria, and are deficient in bacterial killing by NETs (PubMed:20733033). Less than 10% of deficient mice produce a thrombus 48 hours after inferior vena cava stenosis whereas 90% of wild-type mice do (PubMed:23650392). Belongs to the protein arginine deiminase family. immune system process protein-arginine deiminase activity calcium ion binding nucleus cytoplasm chromatin organization nucleosome assembly chromatin remodeling hydrolase activity arginine deiminase activity protein citrullination arginine deiminase pathway stem cell population maintenance macromolecular complex arginine binding histone H3-R26 citrullination histone citrullination protein homodimerization activity innate immune response metal ion binding uc008vne.1 uc008vne.2 uc008vne.3 uc008vne.4 
ENSMUST00000026383.4 Gpr143 ENSMUST00000026383.4 G protein-coupled receptor 143 (from RefSeq NM_010951.3) ENSMUST00000026383.1 ENSMUST00000026383.2 ENSMUST00000026383.3 Gpr143 NM_010951 Oa1 Q549B6 Q549B6_MOUSE uc009uqo.1 uc009uqo.2 uc009uqo.3 G-protein coupled receptor activity lysosomal membrane Golgi apparatus plasma membrane G-protein coupled receptor signaling pathway neuropeptide signaling pathway membrane integral component of membrane apical plasma membrane melanosome localization melanosome transport melanosome organization melanosome membrane dopamine binding calcium-mediated signaling using intracellular calcium source L-DOPA receptor activity melanosome phosphatidylinositol-mediated signaling regulation of calcium-mediated signaling L-DOPA binding tyrosine binding uc009uqo.1 uc009uqo.2 uc009uqo.3 
ENSMUST00000026387.11 Sbds ENSMUST00000026387.11 SBDS ribosome maturation factor (from RefSeq NM_023248.2) ENSMUST00000026387.1 ENSMUST00000026387.10 ENSMUST00000026387.2 ENSMUST00000026387.3 ENSMUST00000026387.4 ENSMUST00000026387.5 ENSMUST00000026387.6 ENSMUST00000026387.7 ENSMUST00000026387.8 ENSMUST00000026387.9 NM_023248 P70122 Q3TG78 Q9CR18 SBDS_MOUSE uc008zuj.1 uc008zuj.2 uc008zuj.3 uc008zuj.4 This gene encodes a protein that is necessary for ribosome function and maintaining normal levels of protein synthesis. The encoded protein may function to activate ribosomes for translation, and may be involved in cellular response to stress and DNA damage. Loss of this gene is embryonic lethal while deficiency of the encoded protein in the pancreas is associated with symptoms of Shwachman-Diamond syndrome. [provided by RefSeq, Dec 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003849.1, SRR1660817.258659.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity). Associates with the 60S ribosomal subunit. Interacts with NPM1, RPA1 and PRKDC. May interact with NIP7. Found in a complex consisting of the 60S ribosomal subunit, SBDS and EFL1. Interacts with CLN3 (By similarity). Cytoplasm. Nucleus, nucleolus Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle Note=Detected in the cytoplasm, but not in the nucleus (PubMed:21536732). Primarily detected in the cytoplasm, and at low levels in nucleus (PubMed:19602484). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (By similarity). Detected in adult liver, brain, heart, spleen, pancreas, kidney, lung and testis (at protein level). Detected in heart, brain, lung, liver, kidney and testis. Embryonic lethality. Embryos cease to develop prior to 6.5 dpc. Reduced assembly of 60S ribosomes and accumulation of halfmer ribosomes. Belongs to the SDO1/SBDS family. spindle pole inner cell mass cell proliferation nucleus nucleoplasm nucleolus cytoplasm spindle cytosol cytoskeleton rRNA processing mitotic spindle organization microtubule binding cell proliferation rRNA binding bone mineralization leukocyte chemotaxis ribosome biogenesis mature ribosome assembly ribosome binding bone marrow development uc008zuj.1 uc008zuj.2 uc008zuj.3 uc008zuj.4 
ENSMUST00000026398.5 Tmt1b ENSMUST00000026398.5 thiol methyltransferase 1B (from RefSeq NM_027853.2) ENSMUST00000026398.1 ENSMUST00000026398.2 ENSMUST00000026398.3 ENSMUST00000026398.4 Mettl7b NM_027853 Q78ID2 Q9DD20 TMT1B_MOUSE Tmt1b uc007hpd.1 uc007hpd.2 uc007hpd.3 Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol- containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Selectively methylates S-centered nucleophiles from metabolites such as hydrogen sulfide and dithiothreitol. Reaction=a thiol + S-adenosyl-L-methionine = a methyl thioether + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:18277, ChEBI:CHEBI:15378, ChEBI:CHEBI:29256, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:86315; EC=2.1.1.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18278; Evidence=; Endoplasmic reticulum membrane ; Peripheral membrane protein Lipid droplet Microsome Cytoplasm, cytosol Note=Highly concentrated in the perinuclear area of the endoplasmic reticulum (ER) and surrounding lipid droplets. May be associated with the specific regions of the LR that form lipid droplets and targeted to the initial deposits of lipids where the lipid droplets form. Belongs to the methyltransferase superfamily. Sequence=AAH24898.1; Type=Erroneous initiation; Evidence=; methyltransferase activity transferase activity methylation uc007hpd.1 uc007hpd.2 uc007hpd.3 
ENSMUST00000026405.10 Bloc1s1 ENSMUST00000026405.10 biogenesis of lysosomal organelles complex-1, subunit 1 (from RefSeq NM_015740.3) BL1S1_MOUSE ENSMUST00000026405.1 ENSMUST00000026405.2 ENSMUST00000026405.3 ENSMUST00000026405.4 ENSMUST00000026405.5 ENSMUST00000026405.6 ENSMUST00000026405.7 ENSMUST00000026405.8 ENSMUST00000026405.9 Gcn5l1 NM_015740 O55102 Q9DC96 uc007hoz.1 uc007hoz.2 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:16760431, PubMed:19546860, PubMed:21998198). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity). May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9. Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8 (PubMed:15102850). The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos (PubMed:21998198). Interacts with ATP5F1A and NDUFA9; involved in their acetylation on lysine residues (By similarity). Interacts with KXD1 (PubMed:22554196). Mitochondrion intermembrane space Mitochondrion matrix Cytoplasm, cytosol Lysosome membrane Belongs to the BLOC1S1 family. protein binding cytoplasm mitochondrion mitochondrial intermembrane space mitochondrial matrix lysosome lysosomal membrane early endosome cytosol anterograde axonal transport aerobic respiration membrane endosomal transport peptidyl-lysine acetylation BLOC-1 complex neuron projection development lysosome localization anterograde synaptic vesicle transport BORC complex axon cytoplasm uc007hoz.1 uc007hoz.2 
ENSMUST00000026406.14 Rdh5 ENSMUST00000026406.14 retinol dehydrogenase 5, transcript variant 1 (from RefSeq NM_134006.5) ENSMUST00000026406.1 ENSMUST00000026406.10 ENSMUST00000026406.11 ENSMUST00000026406.12 ENSMUST00000026406.13 ENSMUST00000026406.2 ENSMUST00000026406.3 ENSMUST00000026406.4 ENSMUST00000026406.5 ENSMUST00000026406.6 ENSMUST00000026406.7 ENSMUST00000026406.8 ENSMUST00000026406.9 NM_134006 O55240 RDH5_MOUSE Rdh4 Rdh5 cRDH rdh uc007how.1 uc007how.2 uc007how.3 uc007how.4 Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:10588954, PubMed:9539749). Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates (By similarity). Reaction=11-cis-retinol + NAD(+) = 11-cis-retinal + H(+) + NADH; Xref=Rhea:RHEA:42060, ChEBI:CHEBI:15378, ChEBI:CHEBI:16066, ChEBI:CHEBI:16302, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.315; Evidence=; Reaction=9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH; Xref=Rhea:RHEA:42052, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78272, ChEBI:CHEBI:78273; Evidence= Reaction=13-cis-retinol + NAD(+) = 13-cis-retinal + H(+) + NADH; Xref=Rhea:RHEA:42056, ChEBI:CHEBI:15378, ChEBI:CHEBI:45479, ChEBI:CHEBI:45487, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=androsterone + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:20381, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:16032, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.209; Evidence=; Reaction=5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta- hydroxy-5alpha-androstan-3-one + H(+) + NADH; Xref=Rhea:RHEA:42004, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:36713, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.53; Evidence=; Inhibited by 9-cis-, 13-cis- and all-trans- retinoic acids, with the most potent inhibitor being 13-cis-retinoic acid. Weakly inhibited by oleic acid. Cofactor metabolism; retinol metabolism. Homodimer. Endoplasmic reticulum membrane ; Multi-pass membrane protein ; Lumenal side Expressed in eye, liver, kidney, brain, intestine, placenta, epididymus and submaxillary gland. In eye, strongly expressed in the retinal pigment epithelium, with lower expression levels detected in the inner segment of the photoreceptor cells and in the outer plexiform layer. In kidney, strong expression detected in the distal tubules and the transitional epithelium in the renal pelvis, with weaker expression detected in the epithelium of the outer stripe of the outer zone of the medulla. In liver, detected in hepatocytes in the centrilobular area. In lung, present in club cells in the epithelium of the bronchiole, in parenchyma and in cartilage surrounding the secondary bronchi. In skin, expressed in epidermis, hair follicles and mast cells in the dermis. Expressed in heart (PubMed:10588954, PubMed:10739682). Not detected in heart (PubMed:9539749). Not detected in lung, spleen, skeletal muscle and testis. Abundantly expressed during embryonic development, especially in the developing central nervous system and sensory organs, cranial and spinal ganglia and endoderm of foregut and hindgut. At 10 dpc, detected along the entire neural tube, the mid- and hindbrain floor, the central canal of the brain vesicles, spinal cord, lung mesenchyme, the trabecular layer of the heart ventricles, endoderm and endodermally-derived structures such as tracheal epithelium and liver. At 11 dpc, expressed in the brain vesicles, along the spinal cord, myotome, migrating muscle progenitor cells in the body wall, cells of the genital ridge, spinal ganglion, liver, cerebellar primordium, basal cells of the neuroepithelium of the mesenchephalic flexure, collections of cells in the pons, Rathke's pouch, spinal and cranial ganglia and the floor plate, retina, lens, optic stalks and the neural crest- derived mesenchyme in the anterior eye segment. During eye development, expression restricted to the retinal pigment epithelium of the posterior hemisphere at 18 dpc, with expression levels increasing postnatally to P16. The last 8 amino acids of the C-terminal tail are important for a proper localization as well as for the in vivo enzymatic activity. Mutant mice develop normally and are fertile. No abnormalities can be found in the retinal structure, rhodopsin content and fundus appearance of their eyes. Mice display a mild visual phenotype of impaired dark adaptation and accumulation of 11-cis- and 13-cis-retinols and 11-cis- and 13-cis-retinyl esters in the eyes. Belongs to the short-chain dehydrogenases/reductases (SDR) family. retinoid metabolic process retinol dehydrogenase activity endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane lipid metabolic process visual perception steroid metabolic process membrane integral component of membrane oxidoreductase activity retinol metabolic process protein homodimerization activity cell body androsterone dehydrogenase activity androstan-3-alpha,17-beta-diol dehydrogenase activity response to stimulus oxidation-reduction process uc007how.1 uc007how.2 uc007how.3 uc007how.4 
ENSMUST00000026408.7 Gdf11 ENSMUST00000026408.7 growth differentiation factor 11 (from RefSeq NM_010272.2) Bmp11 ENSMUST00000026408.1 ENSMUST00000026408.2 ENSMUST00000026408.3 ENSMUST00000026408.4 ENSMUST00000026408.5 ENSMUST00000026408.6 GDF11_MOUSE NM_010272 Q9QX55 Q9R221 Q9Z1W4 uc007hot.1 uc007hot.2 uc007hot.3 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. Mice lacking a functional copy of this gene exhibit impaired anteroposterior patterning and other developmental defects. [provided by RefSeq, Aug 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF092734.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849388, SAMN01164131 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Secreted signal that acts globally to regulate anterior/posterior axial patterning during development (PubMed:10391213). May play critical roles in patterning both mesodermal and neural tissues (PubMed:10391213). It is required for proper vertebral patterning and orofacial development (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:16845371, PubMed:12414726). Homodimer; disulfide-linked (By similarity). Interacts directly with ACVR2B (PubMed:16845371, PubMed:12414726). Interacts directly with ACVR2A (PubMed:12414726). Interacts with ACVR1B, TGFBR1 and ACVR1C in an ACVR2B-dependent manner (PubMed:16845371). Interacts with FST isoform 2/FS288 (By similarity). Secreted Highly expressed in the developing limb bud, initially detected in the distal mesenchyme, and later localizing to regions around the developing bones. Is also expressed in adult dental pulp and brain. First strongly expressed in restricted domains at 8.5 dpc where it is highest in the tail bud. At 10.5 dpc, expressed in the branchial arches, limb bud, tail bud and posterior dorsal neural tube. Later, expressed in terminally-differentiated odontoblasts, the nasal epithelium, retina and specific regions of the brain. Synthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases (By similarity). This produces an inactive form consisting of the mature C-terminal portion non- covalently bound to its cleaved N-terminal propeptide. Activation of the mature form requires additional cleavage of the propeptide by a tolloid-like metalloproteinase. Deficient mice die neonatally showing altered patterning of the axial skeleton and impaired renal, palate, stomach, spleen and pancreatic development. Belongs to the TGF-beta family. skeletal system development metanephros development ureteric bud development cytokine activity transforming growth factor beta receptor binding protein binding extracellular region extracellular space nucleoplasm growth factor activity negative regulation of cell proliferation animal organ morphogenesis anterior/posterior pattern specification positive regulation of pathway-restricted SMAD protein phosphorylation spinal cord anterior/posterior patterning pancreas development macromolecular complex regulation of apoptotic process intracellular membrane-bounded organelle regulation of MAPK cascade negative regulation of cell differentiation negative regulation of neuron differentiation cell development cell maturation camera-type eye morphogenesis palate development SMAD protein signal transduction uc007hot.1 uc007hot.2 uc007hot.3 
ENSMUST00000026409.5 Ormdl2 ENSMUST00000026409.5 ORM1-like 2 (S. cerevisiae), transcript variant 1 (from RefSeq NM_024180.6) ENSMUST00000026409.1 ENSMUST00000026409.2 ENSMUST00000026409.3 ENSMUST00000026409.4 NM_024180 ORML2_MOUSE Q8CF72 Q9CQZ0 Q9CSJ7 Q9CVL6 uc007hoo.1 uc007hoo.2 uc007hoo.3 uc007hoo.4 Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:31880535). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity). Ceramide-sensitive subunit of the serine palmitoyltransferase (SPT) complex, which is also composed of SPTLC1, SPTLC2/3 and SPTSSA/B. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQZ0-1; Sequence=Displayed; Name=2; IsoId=Q9CQZ0-2; Sequence=VSP_016051; Ceramides bind to ORMDL3 N-terminus and stabilize it in a conformation that physically restricts the accessibility of the substrates to their binding sites in the serine palmitoyltransferase (SPT) complex, hence inhibiting SPT catalytic activity. In the absence of ceramides, the N-terminus is flexible and permits substrate binding, thus liberating SPT from inhibition. No overt phenotype (PubMed:31880535). Simultaneous knockdown of ORMDL1 and ORMDL2 do not exhibit any visible phenotype (PubMed:31880535). Simultaneous knockdown of ORMDL2 and ORMDL3 show elevated brain levels of sphingolipids, compared with wild- type animals, but remain fertile and show no sign of neurodegeneration (PubMed:31880535). The triple knockout ORMDL1, ORMDL2 and ORMDL3 is not viable (PubMed:31880535). Belongs to the ORM family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane ceramide metabolic process membrane integral component of membrane SPOTS complex negative regulation of sphingolipid biosynthetic process cellular sphingolipid homeostasis negative regulation of ceramide biosynthetic process uc007hoo.1 uc007hoo.2 uc007hoo.3 uc007hoo.4 
ENSMUST00000026410.2 Dnajc14 ENSMUST00000026410.2 DnaJ heat shock protein family (Hsp40) member C14, transcript variant 3 (from RefSeq NM_028873.5) DJC14_MOUSE ENSMUST00000026410.1 NM_028873 Q3TX73 Q8BUU3 Q921R4 Q9CYB7 uc007hom.1 uc007hom.2 Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain. Endoplasmic reticulum membrane ; Multi-pass membrane protein G-protein coupled receptor binding endoplasmic reticulum endoplasmic reticulum membrane biological_process protein transport membrane integral component of membrane dopamine receptor binding uc007hom.1 uc007hom.2 
ENSMUST00000026411.8 Mmp19 ENSMUST00000026411.8 matrix metallopeptidase 19, transcript variant 1 (from RefSeq NM_021412.3) ENSMUST00000026411.1 ENSMUST00000026411.2 ENSMUST00000026411.3 ENSMUST00000026411.4 ENSMUST00000026411.5 ENSMUST00000026411.6 ENSMUST00000026411.7 MMP19_MOUSE NM_021412 Q8C360 Q9JHI0 Rasi uc007hoh.1 uc007hoh.2 uc007hoh.3 uc007hoh.4 uc007hoh.5 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein develop a diet-induced obesity due to adipocyte hypertophy, exhibit decreased susceptibility to chemical carcinogen-induced skin tumors and early onset of tumoral angiogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]. Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis (By similarity). Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Cell membrane ; Lipid-anchor, GPI- anchor ; Extracellular side Secreted, extracellular space, extracellular matrix Highly expressed in the liver. Expressed in the arterial tunica media of large blood vessels. Expressed in proliferating chondrocytes in the chondroepiphysis during musculoskeletal development. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. Activated by autolytic cleavage after Lys-98. Tyrosine phosphorylated by PKDCC/VLK. Belongs to the peptidase M10A family. angiogenesis ovarian follicle development ovulation from ovarian follicle luteolysis metalloendopeptidase activity extracellular region extracellular space plasma membrane proteolysis multicellular organism development peptidase activity metallopeptidase activity zinc ion binding response to hormone membrane hydrolase activity cell differentiation extracellular matrix organization collagen catabolic process extracellular matrix anchored component of membrane metal ion binding response to cAMP uc007hoh.1 uc007hoh.2 uc007hoh.3 uc007hoh.4 uc007hoh.5 
ENSMUST00000026414.9 Dgka ENSMUST00000026414.9 diacylglycerol kinase, alpha, transcript variant 1 (from RefSeq NM_016811.3) DGKA_MOUSE Dagk1 ENSMUST00000026414.1 ENSMUST00000026414.2 ENSMUST00000026414.3 ENSMUST00000026414.4 ENSMUST00000026414.5 ENSMUST00000026414.6 ENSMUST00000026414.7 ENSMUST00000026414.8 NM_016811 O88673 Q922X2 uc007hoc.1 uc007hoc.2 uc007hoc.3 uc007hoc.4 Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl- lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol. Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10273; Evidence=; Reaction=1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:16937, ChEBI:CHEBI:15378, ChEBI:CHEBI:15850, ChEBI:CHEBI:30616, ChEBI:CHEBI:58014, ChEBI:CHEBI:456216; EC=2.7.1.93; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16938; Evidence=; Reaction=1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn- glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:44072, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52595, ChEBI:CHEBI:73332, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44073; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycerol + ATP = 1,2-dihexadecanoyl-sn- glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:63324, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:72859, ChEBI:CHEBI:82929, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63325; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1- hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43416, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:64839, ChEBI:CHEBI:75466, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43417; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + ATP = 2-(9Z-octadecenoyl)-sn- glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:63328, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:73990, ChEBI:CHEBI:77593, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63329; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40324; Evidence=; Reaction=1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43428, ChEBI:CHEBI:15378, ChEBI:CHEBI:18155, ChEBI:CHEBI:30616, ChEBI:CHEBI:78227, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43429; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2- acetyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:41676, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75936, ChEBI:CHEBI:78385, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41677; Evidence=; Reaction=1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:40403, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77184, ChEBI:CHEBI:77186, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40404; Evidence=; Reaction=1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-O- hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40407, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77185, ChEBI:CHEBI:77187, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40408; Evidence=; Reaction=1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:41672, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:34115, ChEBI:CHEBI:77580, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41673; Evidence=; Stimulated by calcium and phosphatidylserine. Lipid metabolism; glycerolipid metabolism. Monomer. Cytoplasm, cytosol Belongs to the eukaryotic diacylglycerol kinase family. nucleotide binding NAD+ kinase activity diacylglycerol kinase activity calcium ion binding ATP binding phospholipid binding cytosol plasma membrane phosphatidic acid biosynthetic process signal transduction protein kinase C-activating G-protein coupled receptor signaling pathway kinase activity phosphorylation transferase activity intracellular signal transduction diacylglycerol metabolic process glycerolipid metabolic process lipid phosphorylation metal ion binding uc007hoc.1 uc007hoc.2 uc007hoc.3 uc007hoc.4 
ENSMUST00000026415.9 Cdk2 ENSMUST00000026415.9 cyclin dependent kinase 2, transcript variant 2 (from RefSeq NM_016756.4) Cdk2 ENSMUST00000026415.1 ENSMUST00000026415.2 ENSMUST00000026415.3 ENSMUST00000026415.4 ENSMUST00000026415.5 ENSMUST00000026415.6 ENSMUST00000026415.7 ENSMUST00000026415.8 NM_016756 Q3U6X7 Q3U6X7_MOUSE uc007hnz.1 uc007hnz.2 uc007hnz.3 uc007hnz.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm Nucleus, Cajal body Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation kinase activity phosphorylation uc007hnz.1 uc007hnz.2 uc007hnz.3 uc007hnz.4 
ENSMUST00000026420.7 Rps26 ENSMUST00000026420.7 ribosomal protein S26 (from RefSeq NM_013765.2) ENSMUST00000026420.1 ENSMUST00000026420.2 ENSMUST00000026420.3 ENSMUST00000026420.4 ENSMUST00000026420.5 ENSMUST00000026420.6 NM_013765 Q497N1 Q497N1_MOUSE Rps26 uc007hno.1 uc007hno.2 uc007hno.3 uc007hno.4 Belongs to the eukaryotic ribosomal protein eS26 family. cytoplasmic translation mRNA binding structural constituent of ribosome ribosome translation cytosolic small ribosomal subunit negative regulation of RNA splicing polysomal ribosome uc007hno.1 uc007hno.2 uc007hno.3 uc007hno.4 
ENSMUST00000026427.8 Esyt1 ENSMUST00000026427.8 extended synaptotagmin-like protein 1 (from RefSeq NM_011843.2) ENSMUST00000026427.1 ENSMUST00000026427.2 ENSMUST00000026427.3 ENSMUST00000026427.4 ENSMUST00000026427.5 ENSMUST00000026427.6 ENSMUST00000026427.7 ESYT1_MOUSE Fam62a Mbc2 NM_011843 Q3U7R1 Q8C8R1 Q91X62 Q9CVH0 Q9Z1X5 Q9Z1X6 uc007hng.1 uc007hng.2 uc007hng.3 uc007hng.4 Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Interacts with ESYT2 and ESYT3 (By similarity). Interacts (phosphorylated form) with SLC2A4. Q3U7R1; P14142: Slc2a4; NbExp=2; IntAct=EBI-8398881, EBI-7540210; Endoplasmic reticulum membrane ; Multi-pass membrane protein Cell membrane ; Peripheral membrane protein Note=Localizes primarily to the endoplasmic reticulum. Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U7R1-1; Sequence=Displayed; Name=2; IsoId=Q3U7R1-2; Sequence=VSP_018278, VSP_018279; Anchored to the endoplasmic reticulum membrane by a transmembrane hairpin structure; both N-terminus and C-terminus are cytoplasmic. The C2 domains mediate lipid and calcium binding. The N- terminal C2 domain binds calcium ions and is important for calcium- dependent lipid binding and interaction with membranes. Two calcium ions are bound at a high-affinity site and a third calcium ion is bound with lower affinity. May bind up to four calcium ions. In contrast, the second C2 domain apparently does not bind calcium. The third C2 domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate and is required for translocation to the cell membrane in response to increased cytosolic calcium levels (By similarity). The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior (By similarity). Phosphorylated on Ser residues in insulin-treated adipocytes (in vitro); this promotes interaction with SLC2A4. Belongs to the extended synaptotagmin family. calcium ion binding protein binding calcium-dependent phospholipid binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane lipid transport lipid binding phosphatidylethanolamine binding membrane integral component of membrane integral component of endoplasmic reticulum membrane phosphatidylcholine binding intrinsic component of endoplasmic reticulum membrane extrinsic component of cytoplasmic side of plasma membrane phosphatidylinositol binding identical protein binding metal ion binding endoplasmic reticulum-plasma membrane tethering uc007hng.1 uc007hng.2 uc007hng.3 uc007hng.4 
ENSMUST00000026428.4 Myl6b ENSMUST00000026428.4 myosin, light polypeptide 6B (from RefSeq NM_172259.1) ENSMUST00000026428.1 ENSMUST00000026428.2 ENSMUST00000026428.3 MYL6B_MOUSE Myl6b NM_172259 Q8CI43 uc007hne.1 uc007hne.2 Regulatory light chain of myosin. Does not bind calcium. Myosin is a hexamer of 2 heavy chains and 4 light chains. motor activity calcium ion binding muscle contraction skeletal muscle tissue development structural constituent of muscle myosin complex unconventional myosin complex muscle filament sliding uc007hne.1 uc007hne.2 
ENSMUST00000026434.13 Chmp6 ENSMUST00000026434.13 charged multivesicular body protein 6 (from RefSeq NM_001085498.2) CHMP6_MOUSE ENSMUST00000026434.1 ENSMUST00000026434.10 ENSMUST00000026434.11 ENSMUST00000026434.12 ENSMUST00000026434.2 ENSMUST00000026434.3 ENSMUST00000026434.4 ENSMUST00000026434.5 ENSMUST00000026434.6 ENSMUST00000026434.7 ENSMUST00000026434.8 ENSMUST00000026434.9 NM_001085498 P0C0A3 uc007mrd.1 uc007mrd.2 uc007mrd.3 uc007mrd.4 Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity). Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with CHMP4A, CHMP4B and CHMP4C. Interacts with SNF8, VPS25 and VPS36 (By similarity). Endomembrane system Endosome membrane ; Lipid-anchor Late endosome membrane Membrane ; Lipid- anchor Note=Localizes to endosomal membranes. The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity). ISGylated in a CHMP5-dependent manner. Isgylation weakens its interaction with VPS4A (By similarity). Belongs to the SNF7 family. ESCRT III complex endosome nucleus organization vacuolar transport mitotic metaphase plate congression negative regulation of epidermal growth factor-activated receptor activity endosome membrane endomembrane system protein transport membrane late endosome membrane viral budding via host ESCRT complex regulation of protein catabolic process macromolecular complex binding protein N-terminus binding uc007mrd.1 uc007mrd.2 uc007mrd.3 uc007mrd.4 
ENSMUST00000026439.14 Nabp2 ENSMUST00000026439.14 nucleic acid binding protein 2, transcript variant 1 (from RefSeq NM_027257.2) ENSMUST00000026439.1 ENSMUST00000026439.10 ENSMUST00000026439.11 ENSMUST00000026439.12 ENSMUST00000026439.13 ENSMUST00000026439.2 ENSMUST00000026439.3 ENSMUST00000026439.4 ENSMUST00000026439.5 ENSMUST00000026439.6 ENSMUST00000026439.7 ENSMUST00000026439.8 ENSMUST00000026439.9 NM_027257 Obfc2b Q8R2Y9 SOSB1_MOUSE Ssb1 uc007hmq.1 uc007hmq.2 uc007hmq.3 Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM- dependent signaling pathways (By similarity). Component of the SOSS complex, composed of SOSS-B (SOSS- B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7 (By similarity). Nucleus Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment (By similarity). Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells (By similarity). Ubiquitinated in a FBXL5-dependent manner, leading to proteasomal degradation. Belongs to the SOSS-B family. SOSS-B1 subfamily. double-strand break repair via homologous recombination nuclear chromosome, telomeric region nucleic acid binding DNA binding single-stranded DNA binding nucleus nucleoplasm cytosol DNA repair cellular response to DNA damage stimulus mitotic cell cycle checkpoint response to ionizing radiation DNA polymerase binding establishment of protein localization to telomere SOSS complex G-rich strand telomeric DNA binding positive regulation of telomere capping uc007hmq.1 uc007hmq.2 uc007hmq.3 
ENSMUST00000026445.3 Fscn2 ENSMUST00000026445.3 fascin actin-bundling protein 2 (from RefSeq NM_172802.4) ENSMUST00000026445.1 ENSMUST00000026445.2 FSCN2_MOUSE NM_172802 Q32M02 Q8BWU0 uc007msk.1 uc007msk.2 uc007msk.3 uc007msk.4 Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Important for maintaining functional hair-cell bundles in the inner ear. May stiffen the longer stereocilia of hair-cell bundles in the inner ear enabling better force transmission to tip links. Cytoplasm, cytoskeleton Cell projection, stereocilium Note=Found mostly in longer hair-cell stereocilia and, in all stereocilia, present in gradient with the highest concentration at stereocilia tips. Expressed in the inner ear. Abundant in the utricle. Developmentally regulated, appearing in inner-hair cell stereocilia during final stages of elongation. Note=Defects in Fscn2 lead to hair-cell degeneration in the inner ear and are a key contributor to the early-onset, age-related hearing loss (prebycusis) phenotype when in combination with waltzer cadherin 23 mutant. Belongs to the fascin family. actin binding cytoplasm cytoskeleton actin filament organization establishment or maintenance of cell polarity actin cytoskeleton cell migration actin cytoskeleton organization protein binding, bridging stereocilium eye photoreceptor cell development cell projection actin filament binding actin filament bundle assembly uc007msk.1 uc007msk.2 uc007msk.3 uc007msk.4 
ENSMUST00000026448.10 Faap100 ENSMUST00000026448.10 Fanconi anemia core complex associated protein 100 (from RefSeq NM_027980.2) A2ACJ2 ENSMUST00000026448.1 ENSMUST00000026448.2 ENSMUST00000026448.3 ENSMUST00000026448.4 ENSMUST00000026448.5 ENSMUST00000026448.6 ENSMUST00000026448.7 ENSMUST00000026448.8 ENSMUST00000026448.9 FP100_MOUSE Faap100 NM_027980 Q0P653 Q810W2 uc007msm.1 uc007msm.2 uc007msm.3 uc007msm.4 Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed (By similarity). Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and FAAP100. Forms a subcomplex with FANCB and FANCL (By similarity). Nucleus Sequence=AAH34203.1; Type=Erroneous initiation; Evidence=; Sequence=AAH48376.1; Type=Erroneous initiation; Evidence=; Sequence=AK148234; Type=Frameshift; Evidence=; molecular_function DNA binding nucleus nucleoplasm cytosol DNA repair cellular response to DNA damage stimulus biological_process interstrand cross-link repair Fanconi anaemia nuclear complex intermediate filament cytoskeleton uc007msm.1 uc007msm.2 uc007msm.3 uc007msm.4 
ENSMUST00000026449.3 Il23a ENSMUST00000026449.3 interleukin 23, alpha subunit p19 (from RefSeq NM_031252.2) ENSMUST00000026449.1 ENSMUST00000026449.2 IL23A_MOUSE NM_031252 Q9EQ14 uc007hmc.1 uc007hmc.2 uc007hmc.3 Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383, PubMed:11390512, PubMed:16670770). Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (By similarity). This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro- inflammatory cytokines such as interleukin-17A/IL17A (PubMed:19900478). In turn, participates in the early and effective intracellular bacterial clearance (PubMed:16157683). Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed:16648837). Heterodimer with IL12B; disulfide-linked (PubMed:11114383). The heterodimer is known as interleukin IL-23 (PubMed:11114383). Interacts with IL23R; this interaction enables recruitment of IL12RB1 (By similarity). Q9EQ14; P43432: Il12b; NbExp=3; IntAct=EBI-2481329, EBI-2481353; Q9EQ14; P29460: IL12B; Xeno; NbExp=2; IntAct=EBI-2481329, EBI-1029614; Secreted Note=Secreted upon association with IL12B. Secreted by activated dendritic cells (at protein level). Detected in various tissues with higher expression in polarized Th1 cells and activated macrophages. Up-regulated in trigeminal glanglia after herpes simplex virus type 1 infection, in the lung of mice infected with mycobacteria or Klebsiella pneumoniae. Up-regulated in microglia by combined LPS and IFNG stimulation. Up-regulated by FASLG. Mice have no overt phenotype but display compromised humoral and delayed-type hypersensitivity responses. They also have impaired secretion of IL17 and IL17F, higher susceptibility to Klebsiella pneumoniae and Citrobacter rodentium infection, do not develop experimentally-induced autoimmune encephalitis a mouse model of multiple sclerosis, collagen-induced arthritis a rodent model of rheumatoid arthritis and also spontaneous colitis induced by IL10 deficiency a rodent model of inflammatory bowel disease. Transgenic mice expressing Il23a ubiquitously display multiorgan inflammation and infertility, express acute phase genes, have impaired growth and dye prematurely. Belongs to the IL-6 superfamily. positive regulation of T cell mediated cytotoxicity positive regulation of defense response to virus by host immune system process positive regulation of T-helper 1 type immune response cytokine activity protein binding extracellular region extracellular space inflammatory response immune response signal transduction positive regulation of activation of Janus kinase activity negative regulation of interleukin-10 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell proliferation T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein positive regulation of memory T cell differentiation innate immune response interleukin-23 receptor binding positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter tissue remodeling defense response to Gram-negative bacterium positive regulation of NK T cell activation positive regulation of NK T cell proliferation defense response to virus interleukin-23 complex positive regulation of neutrophil chemotaxis positive regulation of T-helper 17 type immune response positive regulation of T-helper 17 cell lineage commitment uc007hmc.1 uc007hmc.2 uc007hmc.3 
ENSMUST00000026452.3 Pde6g ENSMUST00000026452.3 phosphodiesterase 6G, cGMP-specific, rod, gamma, transcript variant 2 (from RefSeq NR_126089.1) ENSMUST00000026452.1 ENSMUST00000026452.2 NR_126089 Pde6g Q542R6 Q542R6_MOUSE uc007mss.1 uc007mss.2 uc007mss.3 uc007mss.4 Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones. Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, ChEBI:CHEBI:58115; EC=3.1.4.35; Evidence= Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain. Belongs to the rod/cone cGMP-PDE gamma subunit family. 3',5'-cyclic-nucleotide phosphodiesterase activity visual perception spectrin binding cGMP binding uc007mss.1 uc007mss.2 uc007mss.3 uc007mss.4 
ENSMUST00000026455.8 Mip ENSMUST00000026455.8 major intrinsic protein of lens fiber (from RefSeq NM_008600.5) ENSMUST00000026455.1 ENSMUST00000026455.2 ENSMUST00000026455.3 ENSMUST00000026455.4 ENSMUST00000026455.5 ENSMUST00000026455.6 ENSMUST00000026455.7 MIP_MOUSE NM_008600 O00285 P51180 Palm Q3UWJ9 Q8BHA2 uc007hlr.1 uc007hlr.2 uc007hlr.3 uc007hlr.4 Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). Homotetramer. Homooctamer formed by head-to-head interaction between homotetramers from adjoining membranes. Interacts with CALM; one CALM molecule interacts with the cytoplasmic domains of two aquaporins, leading to channel closure. Interacts (via C-terminus) with BFSP1 (via C-terminus) in aged lens fiber cells (By similarity). Cell membrane ; Multi-pass membrane protein Cell junction, gap junction Major component of lens fiber gap junctions. Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side (By similarity). Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes (By similarity). Fatty acylated at Met-1 and Lys-238. The acyl modifications, in decreasing order of ion abundance, are: oleoyl (C18:1) > palmitoyl (C16:0) > stearoyl (C18:0) > eicosenoyl (C20:1) > dihomo-gamma- linolenoyl (C20:3) > palmitoleoyl (C16:1) > eicosadienoyl (C20:2). Note=Defects in Mip are a cause of autosomal dominant cataract. The cataract Fraser mutation (Cat-Fr or Shrivelled) is a transposon-induced splicing error that substitutes a long terminal repeat sequence for the C-terminus of Mip. The lens opacity mutation (LOP) is an AA substitution that inhibits targeting of Mip to the cell- membrane. Belongs to the MIP/aquaporin (TC 1.A.8) family. Ref.2 sequence was originally thought to originate from Human. lens development in camera-type eye structural constituent of eye lens protein binding calmodulin binding endoplasmic reticulum plasma membrane integral component of plasma membrane gap junction water transport cell communication visual perception water channel activity channel activity canalicular bile acid transport membrane integral component of membrane apical plasma membrane cell junction intracellular membrane-bounded organelle positive regulation of cell adhesion intracellular canaliculus response to stimulus protein homotetramerization transmembrane transport gap junction-mediated intercellular transport uc007hlr.1 uc007hlr.2 uc007hlr.3 uc007hlr.4 
ENSMUST00000026459.6 Atp5f1b ENSMUST00000026459.6 ATP synthase F1 subunit beta (from RefSeq NM_016774.3) ATPB_MOUSE Atp5b Atp5f1b ENSMUST00000026459.1 ENSMUST00000026459.2 ENSMUST00000026459.3 ENSMUST00000026459.4 ENSMUST00000026459.5 NM_016774 P56480 Q0QEP4 Q3TFD7 Q3TIP9 Q3TK44 Q3TWD5 Q3TX28 Q3U6U4 Q3U774 Q3UB69 Q3UF69 Q8CI65 Q8VEJ5 Q9CTI7 Q9CWX7 uc007hle.1 uc007hle.2 uc007hle.3 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate; Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:57722; Evidence=; F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT- ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). Interacts with PPIF (PubMed:21281446). Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F(1)F(0) ATP synthase and enhances neurons metabolic efficiency (By similarity). Interacts with CLN5 and PPT1 (PubMed:19941651). Interacts with S100A1; this interaction increases F1-ATPase activity (PubMed:17438143). Interacts with MTLN (By similarity). Interacts with TTC5/STRAP; the interaction results in decreased mitochondrial ATP production (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Acetylation of Lys-133 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the ATPase alpha/beta chains family. Sequence=AAH37127.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) angiogenesis calcium ion binding protein binding ATP binding mitochondrion mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex plasma membrane lipid metabolic process ATP biosynthetic process ion transport receptor-mediated endocytosis negative regulation of cell adhesion involved in substrate-bound cell migration cell surface ATP synthesis coupled proton transport membrane ATPase activity lipoprotein particle receptor activity mitochondrial membrane MHC class I protein binding mitochondrial nucleoid mitochondrial ATP synthesis coupled proton transport myelin sheath ADP binding angiostatin binding positive regulation of blood vessel endothelial cell migration membrane raft proton-transporting ATP synthase complex proton-transporting ATP synthase complex, catalytic core F(1) ATP metabolic process proton-transporting ATP synthase activity, rotational mechanism proton-transporting ATPase activity, rotational mechanism regulation of intracellular pH cellular response to interleukin-7 hydrogen ion transmembrane transport uc007hle.1 uc007hle.2 uc007hle.3 
ENSMUST00000026461.8 Prim1 ENSMUST00000026461.8 DNA primase, p49 subunit (from RefSeq NM_008921.2) ENSMUST00000026461.1 ENSMUST00000026461.2 ENSMUST00000026461.3 ENSMUST00000026461.4 ENSMUST00000026461.5 ENSMUST00000026461.6 ENSMUST00000026461.7 NM_008921 Prim1 Q5FW94 Q5FW94_MOUSE uc011xpx.1 uc011xpx.2 uc011xpx.3 uc011xpx.4 Belongs to the eukaryotic-type primase small subunit family. DNA primase activity DNA-directed 5'-3' RNA polymerase activity DNA replication DNA replication, synthesis of RNA primer transferase activity uc011xpx.1 uc011xpx.2 uc011xpx.3 uc011xpx.4 
ENSMUST00000026469.9 Nab2 ENSMUST00000026469.9 Ngfi-A binding protein 2, transcript variant 1 (from RefSeq NM_008668.2) ENSMUST00000026469.1 ENSMUST00000026469.2 ENSMUST00000026469.3 ENSMUST00000026469.4 ENSMUST00000026469.5 ENSMUST00000026469.6 ENSMUST00000026469.7 ENSMUST00000026469.8 NAB2_MOUSE NM_008668 Q61127 Q80VR9 uc011xpt.1 uc011xpt.2 uc011xpt.3 Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability. Homomultimers may associate with EGR1 bound to DNA. Nucleus. Note=Isoform 2 is not localized to the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61127-1; Sequence=Displayed; Name=2; IsoId=Q61127-2; Sequence=VSP_003388, VSP_003389; Highly expressed in brain and thymus, and at lower levels in spleen, kidney, heart and testis. Isoform 1 is predominantly expressed in testis, whereas isoform 3 is more abundant in thymus. By serum stimulation. The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization. The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression. Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain. Belongs to the NAB family. endochondral ossification transcription cofactor activity nucleus regulation of transcription, DNA-templated transcription factor binding Schwann cell differentiation negative regulation of transcription from RNA polymerase III promoter myelination identical protein binding regulation of epidermis development negative regulation of transcription, DNA-templated positive regulation of tau-protein kinase activity uc011xpt.1 uc011xpt.2 uc011xpt.3 
ENSMUST00000026470.6 Shmt2 ENSMUST00000026470.6 serine hydroxymethyltransferase 2 (mitochondrial), transcript variant 1 (from RefSeq NM_028230.4) ENSMUST00000026470.1 ENSMUST00000026470.2 ENSMUST00000026470.3 ENSMUST00000026470.4 ENSMUST00000026470.5 GLYM_MOUSE NM_028230 Q3TFD0 Q99K87 Q9CZN7 Shmt2 uc007hju.1 uc007hju.2 uc007hju.3 uc007hju.4 Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By similarity). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10- methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29452640). Associates with mitochondrial DNA (By similarity). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (By similarity). Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine; Xref=Rhea:RHEA:15481, ChEBI:CHEBI:15377, ChEBI:CHEBI:15636, ChEBI:CHEBI:33384, ChEBI:CHEBI:57305, ChEBI:CHEBI:57453; EC=2.1.2.1; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:15483; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Hydroxymethyltransferase is inhibited by succinylation at Lys-280. One-carbon metabolism; tetrahydrofolate interconversion. Homotetramer; in the presence of bound pyridoxal 5'-phosphate. Homodimer; in the absence of bound pyridoxal 5'-phosphate. Pyridoxal 5'-phosphate binding mediates an important conformation change that is required for tetramerization. Interacts with ABRAXAS2; the interaction is direct. Identified in a complex with ABRAXAS2 and the other subunits of the BRISC complex, at least composed of the ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with ABRAXAS2 and IFNAR1. Interacts with KIRREL3. Mitochondrion Mitochondrion matrix, mitochondrion nucleoid Mitochondrion inner membrane Cytoplasm Nucleus Note=Mainly localizes in the mitochondrion. Also found in the cytoplasm and nucleus as part of the BRISC complex. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZN7-1; Sequence=Displayed; Name=2; IsoId=Q9CZN7-2; Sequence=VSP_059519; Present in the placenta, brain and liver during embryonic development (at protein level). Succinylation at Lys-280 inhibits the hydroxymethyltransferase activity. Desuccinylation by SIRT5 restores the activity, leading to promote cell proliferation. Embryonic lethality after 13.5 days post coitum (dpc) due to mitochondrial respiration defects and retardation of cell growth. Mitochondrial respiration defects are due to reduction of mitochondrial translation. In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one. Belongs to the SHMT family. regulation of oxidative phosphorylation chromatin binding catalytic activity glycine hydroxymethyltransferase activity nucleus cytoplasm mitochondrion mitochondrial inner membrane mitochondrial intermembrane space mitochondrial matrix glycine metabolic process glycine biosynthetic process L-serine metabolic process L-serine biosynthetic process L-serine catabolic process one-carbon metabolic process zinc ion binding positive regulation of cell proliferation L-allo-threonine aldolase activity microtubule cytoskeleton membrane amino acid binding transferase activity glycine biosynthetic process from serine pyridoxal phosphate binding response to type I interferon tetrahydrofolate interconversion mitochondrial nucleoid identical protein binding tetrahydrofolate metabolic process folic acid metabolic process cobalt ion binding protein tetramerization protein homotetramerization regulation of mitochondrial translation protein K63-linked deubiquitination BRISC complex serine binding regulation of aerobic respiration cellular response to tetrahydrofolate uc007hju.1 uc007hju.2 uc007hju.3 uc007hju.4 
ENSMUST00000026472.10 Inhbc ENSMUST00000026472.10 inhibin beta-C (from RefSeq NM_010565.4) ENSMUST00000026472.1 ENSMUST00000026472.2 ENSMUST00000026472.3 ENSMUST00000026472.4 ENSMUST00000026472.5 ENSMUST00000026472.6 ENSMUST00000026472.7 ENSMUST00000026472.8 ENSMUST00000026472.9 INHBC_MOUSE NM_010565 P55104 Q61452 uc007hjj.1 uc007hjj.2 uc007hjj.3 uc007hjj.4 uc007hjj.5 This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026140.1, SRR1660821.98489.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity). Secreted Mainly expressed in the adult liver. Belongs to the TGF-beta family. cytokine activity transforming growth factor beta receptor binding hormone activity extracellular region extracellular space growth factor activity positive regulation of pathway-restricted SMAD protein phosphorylation regulation of apoptotic process regulation of MAPK cascade cell development SMAD protein signal transduction uc007hjj.1 uc007hjj.2 uc007hjj.3 uc007hjj.4 uc007hjj.5 
ENSMUST00000026474.5 Gli1 ENSMUST00000026474.5 GLI-Kruppel family member GLI1 (from RefSeq NM_010296.2) ENSMUST00000026474.1 ENSMUST00000026474.2 ENSMUST00000026474.3 ENSMUST00000026474.4 G5E857 GLI1_MOUSE Gli NM_010296 P47806 Q9QYK1 uc007hjf.1 uc007hjf.2 uc007hjf.3 Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. Interacts with KIF7 (PubMed:19592253). Interacts with STK36. Interacts with ZIC1; the interaction enhances transcription activation. Interacts with SUFU; this inhibits transcriptional activation by GLI1 (By similarity). Cytoplasm Nucleus Note=Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1. Is detected on days 10 through 18 of embryonic development. During gestation it is detected in meckels precartilage mesenchyme, the basis occipitus, rib mesenchymal condensations, primordial vertebral bodies, digital mesenchymal condensations in forefoot and hindfoot plates, the ependymal layer of the spinal cord, and the mesoderm of the gastrointestinal tract. Expression persists throughout gestation in developing bone and cartilage of the extremities, the ribs, and the vertebral bodies as well as the gastrointestinal tract mesoderm. Phosphorylated in vitro by ULK3. Acetylation at Lys-520 down-regulates transcriptional activity. Deacetylated by HDAC1. Ubiquitinated by the CRL2(FEM1B) complex, suppressing GLI1 transcriptional activator activity. Belongs to the GLI C2H2-type zinc-finger protein family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding osteoblast differentiation nucleic acid binding DNA binding chromatin binding protein binding nucleus nucleoplasm cytoplasm cytosol cilium axoneme signal transduction smoothened signaling pathway multicellular organism development spermatogenesis ventral midline development microtubule binding positive regulation of cell proliferation response to wounding epidermal cell differentiation dorsal/ventral pattern formation proximal/distal pattern formation cerebellar cortex morphogenesis smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation pituitary gland development cell differentiation lung development positive regulation of cell migration prostate gland development sequence-specific DNA binding transcription regulatory region DNA binding regulation of osteoblast differentiation positive regulation of DNA replication positive regulation of smoothened signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding notochord regression positive regulation of cardiac muscle cell proliferation canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway liver regeneration positive regulation of cell cycle G1/S phase transition regulation of hepatocyte proliferation ciliary tip uc007hjf.1 uc007hjf.2 uc007hjf.3 
ENSMUST00000026475.15 Ddit3 ENSMUST00000026475.15 DNA-damage inducible transcript 3, transcript variant 1 (from RefSeq NM_007837.4) Chop Chop10 DDIT3_MOUSE ENSMUST00000026475.1 ENSMUST00000026475.10 ENSMUST00000026475.11 ENSMUST00000026475.12 ENSMUST00000026475.13 ENSMUST00000026475.14 ENSMUST00000026475.2 ENSMUST00000026475.3 ENSMUST00000026475.4 ENSMUST00000026475.5 ENSMUST00000026475.6 ENSMUST00000026475.7 ENSMUST00000026475.8 ENSMUST00000026475.9 Gadd153 NM_007837 P35639 Q91YW9 uc007hiy.1 uc007hiy.2 uc007hiy.3 uc007hiy.4 Multifunctional transcription factor in endoplasmic reticulum (ER) stress response (PubMed:15601821, PubMed:19752026). Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress (PubMed:15601821, PubMed:19752026). Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes (PubMed:1547942). Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes (PubMed:1547942). Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L (PubMed:12706815, PubMed:15775988, PubMed:21159964, PubMed:14684614, PubMed:19919955). Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG) (By similarity). Together with ATF4, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress (PubMed:22242125, PubMed:23624402). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity (By similarity). Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (PubMed:16670335). Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling (PubMed:22265908). Heterodimer. Interacts with TCF7L2/TCF4, EP300/P300, HDAC5 and HDAC6 (By similarity). Interacts with TRIB3 which blocks its association with EP300/P300 (By similarity). Interacts with FOXO3, and CEBPB (By similarity). Interacts with ATF4 (PubMed:23624402). Interacts with HDAC1 (PubMed:22242125). [Isoform 1]: Interacts with isoform AltDDIT3 of DDIT3. P35639; Q06507: Atf4; NbExp=3; IntAct=EBI-10636142, EBI-77383; Cytoplasm Nucleus Note=Present in the cytoplasm under non- stressed conditions and ER stress leads to its nuclear accumulation. Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=P35639-1; Sequence=Displayed; Name=AltDDIT3; IsoId=A0A2R8VHR8-1; Sequence=External; [Isoform 1]: By various stress, such as oxidative stress, amino-acid deprivation, hypoxia and ER stress (PubMed:16670335, PubMed:19752026, PubMed:19855386, PubMed:19919955, PubMed:21159964, PubMed:22242125). Specifically produced in response to stress: in absence of stress, AltDDIT3, the upstream ORF of this bicistronic gene, is translated, thereby preventing its translation (PubMed:21285359). During ER stress, induced by a EIF2AK3/ATF4 pathway and/or ERN1/ATF6 pathway (PubMed:19855386, PubMed:21159964). Expression is suppressed by TLR-TRIF signaling pathway during prolonged ER stress (PubMed:16670335, PubMed:19752026, PubMed:19855386, PubMed:19919955, PubMed:21159964, PubMed:22242125). The N-terminal region is necessary for its proteasomal degradation, transcriptional activity and interaction with EP300/P300. Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity. Belongs to the bZIP family. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding blood vessel maturation DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus cytoplasm late endosome regulation of transcription, DNA-templated apoptotic process ER overload response response to unfolded protein cell cycle cell cycle arrest transcription factor binding cAMP response element binding protein binding regulation of autophagy Wnt signaling pathway endoplasmic reticulum unfolded protein response positive regulation of interleukin-8 production negative regulation of CREB transcription factor activity protein-DNA complex autophagy in response to ER overload response to endoplasmic reticulum stress CHOP-C/EBP complex response to starvation mRNA transcription from RNA polymerase II promoter protein homodimerization activity positive regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity leucine zipper domain binding positive regulation of neuron apoptotic process transcription regulatory region DNA binding regulation of transcription involved in anterior/posterior axis specification cell redox homeostasis negative regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity positive regulation of sequence-specific DNA binding transcription factor activity release of sequestered calcium ion into cytosol protein oligomerization negative regulation of protein kinase B signaling intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress establishment of protein localization to mitochondrion negative regulation of canonical Wnt signaling pathway RNA polymerase II transcription factor complex positive regulation of neuron death negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to nitrosative stress CHOP-ATF4 complex CHOP-ATF3 complex negative regulation of determination of dorsal identity positive regulation of intrinsic apoptotic signaling pathway sequence-specific DNA binding uc007hiy.1 uc007hiy.2 uc007hiy.3 uc007hiy.4 
ENSMUST00000026479.11 Dctn2 ENSMUST00000026479.11 dynactin 2, transcript variant 3 (from RefSeq NM_027151.2) DCTN2_MOUSE ENSMUST00000026479.1 ENSMUST00000026479.10 ENSMUST00000026479.2 ENSMUST00000026479.3 ENSMUST00000026479.4 ENSMUST00000026479.5 ENSMUST00000026479.6 ENSMUST00000026479.7 ENSMUST00000026479.8 ENSMUST00000026479.9 NM_027151 Q99KJ8 uc007hiu.1 uc007hiu.2 uc007hiu.3 uc007hiu.4 Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (PubMed:14983524). Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters and consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin (By similarity). Interacts with BICD2 and CEP135 (PubMed:11483508, PubMed:14983524, PubMed:22956769). Interacts with DYNAP. Interacts with ECPAS. Interacts with MAPRE1 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome mbrane ; Peripheral membrane protein Present at high levels in both cytoplasmic and membrane-associated forms in neonates. Levels of membrane-associated form are greatly reduced in the adult. Belongs to the dynactin subunit 2 family. mitotic cell cycle kinetochore motor activity protein binding cytoplasm centrosome microtubule organizing center cytosol cytoskeleton dynactin complex microtubule microtubule-based process mitotic spindle organization cell proliferation membrane protein kinase binding dynein complex growth cone spectrin binding vesicle melanosome transport identical protein binding protein localization to centrosome uc007hiu.1 uc007hiu.2 uc007hiu.3 uc007hiu.4 
ENSMUST00000026480.13 Ttc4 ENSMUST00000026480.13 tetratricopeptide repeat domain 4, transcript variant 1 (from RefSeq NM_028209.2) ENSMUST00000026480.1 ENSMUST00000026480.10 ENSMUST00000026480.11 ENSMUST00000026480.12 ENSMUST00000026480.2 ENSMUST00000026480.3 ENSMUST00000026480.4 ENSMUST00000026480.5 ENSMUST00000026480.6 ENSMUST00000026480.7 ENSMUST00000026480.8 ENSMUST00000026480.9 NM_028209 Q8R3H9 TTC4_MOUSE uc008tys.1 uc008tys.2 uc008tys.3 uc008tys.4 May act as a co-chaperone for HSP90AB1 (By similarity). Interacts (via TPR repeats) with HSP90AB1 (By similarity). Interacts with HSPA8, CDC6 and TBK1 (By similarity). Interacts with isoform 1 and isoform 3 of MSL1 (PubMed:17335777). Nucleus cleus, nucleoplasm Cytoplasm Note=Predominantly nuclear in the G1 and S phases of cell cycle and is evenly distributed between the nucleus and cytoplasm in the G2 phase (PubMed:19390865). MSL1 can promote its nuclear localization (PubMed:19390865, PubMed:24913909). Expressed at high levels in the heart, testis, kidney, brain and tongue (PubMed:19390865). Expressed at low levels in the stomach, lung and liver (PubMed:19390865). Belongs to the TTC4 family. molecular_function protein binding cellular_component nucleus cytoplasm biological_process innate immune response defense response to virus uc008tys.1 uc008tys.2 uc008tys.3 uc008tys.4 
ENSMUST00000026487.6 Ier3ip1 ENSMUST00000026487.6 immediate early response 3 interacting protein 1 (from RefSeq NM_025409.3) ENSMUST00000026487.1 ENSMUST00000026487.2 ENSMUST00000026487.3 ENSMUST00000026487.4 ENSMUST00000026487.5 IR3IP_MOUSE Ier3ip1 NM_025409 Q9CR20 uc008fqr.1 uc008fqr.2 uc008fqr.3 uc008fqr.4 uc008fqr.5 Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors (By similarity). Acts as a regulator of the unfolded protein response (UPR) (PubMed:28915629). Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the YOS1 family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus ER to Golgi vesicle-mediated transport membrane integral component of membrane ER to Golgi transport vesicle integral component of Golgi membrane regulation of fibroblast apoptotic process uc008fqr.1 uc008fqr.2 uc008fqr.3 uc008fqr.4 uc008fqr.5 
ENSMUST00000026494.14 Ark2c ENSMUST00000026494.14 arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C (from RefSeq NM_001164504.1) ARK2C_MOUSE Ark2c E9QAU8 ENSMUST00000026494.1 ENSMUST00000026494.10 ENSMUST00000026494.11 ENSMUST00000026494.12 ENSMUST00000026494.13 ENSMUST00000026494.2 ENSMUST00000026494.3 ENSMUST00000026494.4 ENSMUST00000026494.5 ENSMUST00000026494.6 ENSMUST00000026494.7 ENSMUST00000026494.8 ENSMUST00000026494.9 Gm96 NM_001164504 Q3UZA7 Rnf165 uc008frj.1 uc008frj.2 uc008frj.3 E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation (PubMed:23610558). Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP (PubMed:23610558). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL (PubMed:23610558). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Binds free ubiquitin non-covalently via its RING- type zinc finger. Ubiquitin-binding leads to enhance the E3 ubiquitin- protein ligase activity by stabilizing the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the 'closed' conformation and activating ubiquitin transfer. Monomer; binding to the ubiquitin-conjugating enzyme E2 does not trigger homodimerization. Nucleus Expressed in neurons of the nervous system. The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity and binds directly to free ubiquitin. Non-covalent ubiquitin-binding stabilizes the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the 'closed' conformation and stimulates ubiquitin transfer. Around 10% of mice die at birth. While surviving pups are the same size as their littermates at birth, they fail to thrive and grow, reaching only 50% of the size of their siblings at postnatal day 15. They die before weaning during the first 3 postnatal weeks. Null pups display relaxed forepaws and reduced dorsiflexion. Hind limb defects are also observed. Defects are caused by inefficient growth of motor axons to distant muscles. Belongs to the Arkadia family. protein polyubiquitination protein binding nucleus axonogenesis motor neuron axon guidance zinc ion binding multicellular organism aging transferase activity protein catabolic process positive regulation of BMP signaling pathway macromolecular complex forelimb morphogenesis metal ion binding limb development innervation muscle structure development ubiquitin protein ligase activity uc008frj.1 uc008frj.2 uc008frj.3 
ENSMUST00000026495.15 Atp5f1a ENSMUST00000026495.15 ATP synthase F1 subunit alpha (from RefSeq NM_007505.2) ATPA_MOUSE Atp5a1 Atp5f1a ENSMUST00000026495.1 ENSMUST00000026495.10 ENSMUST00000026495.11 ENSMUST00000026495.12 ENSMUST00000026495.13 ENSMUST00000026495.14 ENSMUST00000026495.2 ENSMUST00000026495.3 ENSMUST00000026495.4 ENSMUST00000026495.5 ENSMUST00000026495.6 ENSMUST00000026495.7 ENSMUST00000026495.8 ENSMUST00000026495.9 NM_007505 Q03265 Q3TFN0 Q3THN8 Q3TPR0 Q3TPV3 Q3TZU3 Q3UIR7 Q543Y6 uc008fru.1 uc008fru.2 uc008fru.3 uc008fru.4 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity). F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c (By similarity). Interacts with ATPAF2. Interacts with HRG; the interaction occurs on the surface of T-cells and alters the cell morphology when associated with concanavalin (in vitro). Interacts with PLG (angiostatin peptide); the interaction inhibits most of the angiogenic properties of angiostatin (By similarity). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). Interacts with BLOC1S1 (By similarity). Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F(1)F(0) ATP synthase and enhances neurons metabolic efficiency (By similarity). Interacts with CLN5 and PPT1 (PubMed:19941651). Interacts with S100A1; this interaction increases F1-ATPase activity (PubMed:17438143). Interacts with ABCB7; this interaction allows the regulation of cellular iron homeostasis and cellular reactive oxygen species (ROS) levels in cardiomyocytes (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Cell membrane ; Peripheral membrane protein ; Extracellular side Note=Colocalizes with HRG on the cell surface of T-cells. Acetylated on lysine residues. BLOC1S1 is required for acetylation (By similarity). Acetylation of Lys-132, Lys-230 and Lys-498 is observed in liver mitochondria from fasted mice but not from fed mice. The siderophore enterobactin (Ent) produced by enteric bacteria binds Fe(3+) and helps bacteria scavenge iron ions from the environment. As a consequence, the mammalian siderocalin LCN2 plays an important role in defense against bacterial infections by sequestering iron bound to microbial siderophores. LCN2 can also bind iron bound to endogenous or nutrient-derived iron chelators and plays an important role in cellular iron homeostasis. Enterobactin produced by non- pathogenic E.coli strains can facilitate mitochondrial iron assimilation, suggesting that iron bound to siderophores from non- pathogenic bacteria may contribute to iron absorption by the host. Belongs to the ATPase alpha/beta chains family. nucleotide binding mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) negative regulation of endothelial cell proliferation protease binding protein binding ATP binding nucleus mitochondrion mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex plasma membrane lipid metabolic process ATP biosynthetic process ion transport COP9 signalosome cell surface ATP synthesis coupled proton transport membrane ATPase activity adenyl ribonucleotide binding MHC class I protein binding myelin sheath ADP binding angiostatin binding positive regulation of blood vessel endothelial cell migration membrane raft proton-transporting ATP synthase complex proton-transporting ATP synthase complex, catalytic core F(1) ATP metabolic process proton-transporting ATP synthase activity, rotational mechanism hydrogen ion transmembrane transport uc008fru.1 uc008fru.2 uc008fru.3 uc008fru.4 
ENSMUST00000026498.5 Crisp1 ENSMUST00000026498.5 cysteine-rich secretory protein 1 (from RefSeq NM_009638.3) Crisp1 ENSMUST00000026498.1 ENSMUST00000026498.2 ENSMUST00000026498.3 ENSMUST00000026498.4 NM_009638 Q545H0 Q545H0_MOUSE uc008coh.1 uc008coh.2 uc008coh.3 Belongs to the CRISP family. Lacks conserved residue(s) required for the propagation of feature annotation. extracellular region uc008coh.1 uc008coh.2 uc008coh.3 
ENSMUST00000026499.6 Crisp3 ENSMUST00000026499.6 cysteine-rich secretory protein 3 (from RefSeq NM_009639.3) A2RTK2 Aeg-2 Aeg2 CRIS3_MOUSE ENSMUST00000026499.1 ENSMUST00000026499.2 ENSMUST00000026499.3 ENSMUST00000026499.4 ENSMUST00000026499.5 NM_009639 Q03402 uc008cog.1 uc008cog.2 uc008cog.3 This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. Interacts with A1BG (By similarity). Interacts with KNG1 isoform LMW. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory granules of granular convoluted tubules cells. Expressed in submandibular gland. Exponential increase between days 25 and 30 after birth. By androgens. Belongs to the CRISP family. extracellular region extracellular space transport vesicle cytoplasmic vesicle uc008cog.1 uc008cog.2 uc008cog.3 
ENSMUST00000026500.12 Avil ENSMUST00000026500.12 advillin, transcript variant 1 (from RefSeq NM_009635.4) AVIL_MOUSE Advil Avil ENSMUST00000026500.1 ENSMUST00000026500.10 ENSMUST00000026500.11 ENSMUST00000026500.2 ENSMUST00000026500.3 ENSMUST00000026500.4 ENSMUST00000026500.5 ENSMUST00000026500.6 ENSMUST00000026500.7 ENSMUST00000026500.8 ENSMUST00000026500.9 NM_009635 O70466 O88398 Q3U1K5 uc007hhl.1 uc007hhl.2 uc007hhl.3 Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1- mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis (PubMed:15247299, PubMed:18160648). In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (By similarity). Associates (via C-terminus) with actin (By similarity). Interacts with F-actin (By similarity). Interacts with SCARF1; the interaction occurs in embryonic dorsal root ganglions at 18 dpc and induces neurite-like outgrowth (PubMed:15247299). Interacts with PLCE1. Interacts with ACTR2 and ACTR3; associates with the ARP2/3 complex (By similarity). Cytoplasm, cytoskeleton Cell projection, lamellipodium Cell junction, focal adhesion Cell projection, neuron projection Cell projection, axon Note=In podocytes, present in the F- actin-enriched cell periphery that generates lamellipodia and focal adhesions. Most highly expressed in the endometrium of the uterus, the intestinal villi and the testes. Weaker expression also detected in the brain, dorsal root ganglions and on the surface of the tongue. Expressed almost exclusively in peripheral sensory neurons (craniofacial and dorsal root ganglia (DRG) sensory neurons), but also in trigeminal ganglia (TG) Me5 proprioceptive neurons and Mo5 motoneurons. Half of the homozygous mice die during embryogenesis, the other 50% do not show any noticeable abnormality in development, growth or behavior and are fertile. Belongs to the villin/gelsolin family. actin binding protein binding cytoplasm cytoskeleton cytoskeleton organization actin filament organization nervous system development positive regulation of neuron projection development axon cell projection neuron projection actin filament binding actin filament capping cilium assembly uc007hhl.1 uc007hhl.2 uc007hhl.3 
ENSMUST00000026506.5 Clns1a ENSMUST00000026506.5 chloride channel, nucleotide-sensitive, 1A (from RefSeq NM_023671.2) Clns1a ENSMUST00000026506.1 ENSMUST00000026506.2 ENSMUST00000026506.3 ENSMUST00000026506.4 NM_023671 Q923F1 Q923F1_MOUSE uc009ijr.1 uc009ijr.2 uc009ijr.3 uc009ijr.4 Nucleus Belongs to the pICln (TC 1.A.47) family. spliceosomal snRNP assembly nucleus nucleoplasm cytosol plasma membrane chloride transport cell volume homeostasis methylosome pICln-Sm protein complex protein heterodimerization activity uc009ijr.1 uc009ijr.2 uc009ijr.3 uc009ijr.4 
ENSMUST00000026519.10 4833420G17Rik ENSMUST00000026519.10 RIKEN cDNA 4833420G17 gene, transcript variant 3 (from RefSeq NM_001360805.1) CE034_MOUSE ENSMUST00000026519.1 ENSMUST00000026519.2 ENSMUST00000026519.3 ENSMUST00000026519.4 ENSMUST00000026519.5 ENSMUST00000026519.6 ENSMUST00000026519.7 ENSMUST00000026519.8 ENSMUST00000026519.9 NM_001360805 Q3TUB6 Q3UF19 Q3UJC8 Q78HE1 Q8K3D5 Q9CUS5 Q9D822 uc007rzj.1 uc007rzj.2 uc007rzj.3 uc007rzj.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UJC8-1; Sequence=Displayed; Name=2; IsoId=Q3UJC8-2; Sequence=VSP_027120, VSP_027121; Sequence=BAB25748.1; Type=Frameshift; Evidence=; Sequence=BAE36055.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc007rzj.1 uc007rzj.2 uc007rzj.3 uc007rzj.4 
ENSMUST00000026520.14 Paip1 ENSMUST00000026520.14 polyadenylate binding protein-interacting protein 1, transcript variant 1 (from RefSeq NM_145457.5) ENSMUST00000026520.1 ENSMUST00000026520.10 ENSMUST00000026520.11 ENSMUST00000026520.12 ENSMUST00000026520.13 ENSMUST00000026520.2 ENSMUST00000026520.3 ENSMUST00000026520.4 ENSMUST00000026520.5 ENSMUST00000026520.6 ENSMUST00000026520.7 ENSMUST00000026520.8 ENSMUST00000026520.9 NM_145457 PAIP1_MOUSE Q8VE62 Q9WUC9 uc007rzd.1 uc007rzd.2 uc007rzd.3 uc007rzd.4 Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with EIF4A (By similarity). Cytoplasm Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation. RNA binding protein binding cellular_component cytoplasm regulation of translation regulation of translational initiation translation activator activity positive regulation of translation uc007rzd.1 uc007rzd.2 uc007rzd.3 uc007rzd.4 
ENSMUST00000026537.13 Paox ENSMUST00000026537.13 polyamine oxidase (exo-N4-amino), transcript variant 1 (from RefSeq NM_153783.4) ENSMUST00000026537.1 ENSMUST00000026537.10 ENSMUST00000026537.11 ENSMUST00000026537.12 ENSMUST00000026537.2 ENSMUST00000026537.3 ENSMUST00000026537.4 ENSMUST00000026537.5 ENSMUST00000026537.6 ENSMUST00000026537.7 ENSMUST00000026537.8 ENSMUST00000026537.9 NM_153783 PAOX_MOUSE Pao Q8C0L6 Q8K254 uc009khb.1 uc009khb.2 uc009khb.3 Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12660232, PubMed:28029774). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)- acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12660232). Reaction=H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine; Xref=Rhea:RHEA:25800, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:30322, ChEBI:CHEBI:57834, ChEBI:CHEBI:58101; EC=1.5.3.13; Evidence=; Reaction=H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine; Xref=Rhea:RHEA:25812, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:30322, ChEBI:CHEBI:58324, ChEBI:CHEBI:326268; EC=1.5.3.13; Evidence=; Reaction=H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine; Xref=Rhea:RHEA:25868, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:30322, ChEBI:CHEBI:58324, ChEBI:CHEBI:58550; EC=1.5.3.13; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. Kinetic parameters: KM=1.78 uM for N(1)-acetylspermine ; KM=36.8 uM for N(1)-acetylspermidine ; KM=716 uM for spermine ; KM=150 uM for N(1),N(12)-diacetylspermine ; Amine and polyamine metabolism; spermine metabolism. Monomer. Peroxisome Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C0L6-1; Sequence=Displayed; Name=2; IsoId=Q8C0L6-2; Sequence=VSP_011263, VSP_011264; Widely expressed at different developmental stages. Expressed at high level in the liver and the stomach, expressed at lower level in heart, spleen, thymus, small intestine, muscle, pancreas, uterus, and breast and expressed at very low level in brain, kidney, lung, testis, skin, adrenal gland and prostate gland. Expression increased during embryonic development: there is a gradual increase in the tissues on going from 8.5 to 19 day embryos. In the breast, expression is very low in virgin mouse and quite high in pregnant mouse, but decreases in lactating and involuting breasts. By polyamine analogs. Oxidizes N(1)-acetylated polyamines on the exo-side of their N(4)-amino groups. Plant PAO oxidizes spermine on the endo-side of the N(4)-nitrogen (By similarity). N-ethylated polyamines are also good substrates for this enzyme: they have been used for cancer clinical trials. They down- regulate polyamine biosynthetic enzymes, but dramatically up-regulate SSAT synthesis, which results in mammalian cells becoming apoptotic. Belongs to the flavin monoamine oxidase family. cytoplasm peroxisome peroxisomal matrix polyamine catabolic process spermine metabolic process putrescine biosynthetic process putrescine catabolic process oxidoreductase activity spermidine catabolic process spermine catabolic process polyamine oxidase activity N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity spermine:oxygen oxidoreductase (spermidine-forming) activity spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity oxidation-reduction process positive regulation of spermidine biosynthetic process uc009khb.1 uc009khb.2 uc009khb.3 
ENSMUST00000026538.13 Echs1 ENSMUST00000026538.13 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (from RefSeq NM_053119.3) ECHM_MOUSE ENSMUST00000026538.1 ENSMUST00000026538.10 ENSMUST00000026538.11 ENSMUST00000026538.12 ENSMUST00000026538.2 ENSMUST00000026538.3 ENSMUST00000026538.4 ENSMUST00000026538.5 ENSMUST00000026538.6 ENSMUST00000026538.7 ENSMUST00000026538.8 ENSMUST00000026538.9 Echs1 NM_053119 Q3TJK2 Q6GQS2 Q6PEN1 Q8BH95 Q99LX7 uc009kgx.1 uc009kgx.2 uc009kgx.3 Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl- CoA) to the corresponding (3S)-3-hydroxyacyl-CoA species through addition of a water molecule to the double bond. Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (By similarity). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)- butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA). Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (By similarity). Plays a key role in the beta- oxidation spiral of short- and medium-chain fatty acid oxidation. At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)- hydroxyhexanoyl-CoA) (By similarity). Reaction=a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O; Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318, ChEBI:CHEBI:58856; EC=4.2.1.17; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:16107; Evidence=; Reaction=a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA; Xref=Rhea:RHEA:45228, ChEBI:CHEBI:58521, ChEBI:CHEBI:85097; EC=5.3.3.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45229; Evidence=; Reaction=(3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA; Xref=Rhea:RHEA:45736, ChEBI:CHEBI:62077, ChEBI:CHEBI:84790; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45737; Evidence=; Reaction=(3S)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O; Xref=Rhea:RHEA:26558, ChEBI:CHEBI:15377, ChEBI:CHEBI:57316, ChEBI:CHEBI:57332; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:26560; Evidence=; Reaction=3-hydroxyisovaleryl-CoA = 3-methyl-(2E)-butenoyl-CoA + H2O; Xref=Rhea:RHEA:31079, ChEBI:CHEBI:15377, ChEBI:CHEBI:57344, ChEBI:CHEBI:62555; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31081; Evidence=; Reaction=3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O; Xref=Rhea:RHEA:26518, ChEBI:CHEBI:15377, ChEBI:CHEBI:57367, ChEBI:CHEBI:58528; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:26520; Evidence=; Reaction=3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O; Xref=Rhea:RHEA:45584, ChEBI:CHEBI:15377, ChEBI:CHEBI:57332, ChEBI:CHEBI:78611; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:45586; Evidence=; Reaction=(2E)-2-methylpropenoyl-CoA + H2O = (S)-3-hydroxyisobutanoyl- CoA; Xref=Rhea:RHEA:31175, ChEBI:CHEBI:15377, ChEBI:CHEBI:62500, ChEBI:CHEBI:62611; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31176; Evidence=; Reaction=(3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O; Xref=Rhea:RHEA:30547, ChEBI:CHEBI:15377, ChEBI:CHEBI:62075, ChEBI:CHEBI:62077; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:30549; Evidence=; Reaction=(3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O; Xref=Rhea:RHEA:31191, ChEBI:CHEBI:15377, ChEBI:CHEBI:61406, ChEBI:CHEBI:62616; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31193; Evidence=; Lipid metabolism; fatty acid beta-oxidation. Homohexamer; dimer of trimers. Mitochondrion matrix Acetylation of Lys-101 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the enoyl-CoA hydratase/isomerase family. catalytic activity enoyl-CoA hydratase activity mitochondrion mitochondrial matrix lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation lyase activity isomerase activity uc009kgx.1 uc009kgx.2 uc009kgx.3 
ENSMUST00000026539.14 Fuom ENSMUST00000026539.14 fucose mutarotase, transcript variant 1 (from RefSeq NM_026928.4) ENSMUST00000026539.1 ENSMUST00000026539.10 ENSMUST00000026539.11 ENSMUST00000026539.12 ENSMUST00000026539.13 ENSMUST00000026539.2 ENSMUST00000026539.3 ENSMUST00000026539.4 ENSMUST00000026539.5 ENSMUST00000026539.6 ENSMUST00000026539.7 ENSMUST00000026539.8 ENSMUST00000026539.9 FUCM_MOUSE Le51 NM_026928 Q3TQB6 Q76K68 Q8C566 Q8C8P5 Q8R2K1 uc009kgu.1 uc009kgu.2 uc009kgu.3 uc009kgu.4 Involved in the interconversion between alpha- and beta-L- fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. Reaction=alpha-L-fucose = beta-L-fucose; Xref=Rhea:RHEA:25580, ChEBI:CHEBI:42548, ChEBI:CHEBI:42589; EC=5.1.3.29; Evidence=; Carbohydrate metabolism; L-fucose metabolism. Mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seems catalytically inactive. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8R2K1-1; Sequence=Displayed; Name=2; IsoId=Q8R2K1-2; Sequence=VSP_025085; Name=3; IsoId=Q8R2K1-3; Sequence=VSP_025082; Name=4; IsoId=Q8R2K1-4; Sequence=VSP_025083; Name=5; IsoId=Q8R2K1-5; Sequence=VSP_025084; Widely expressed in various tissues and cell lines, including kidney, liver, and pancreas, marginally in muscle and testis. Deficient female mice show reduced sexual receptivity, as measured by lordosis quotient and masculinized sexual behaviors in female mice. Display a reduced number of tyrosine hydroxylase-positive neurons in the anteroventral periventricular nucleus, a sexually dimorphic feature in rats and mice. Embryos at 16.5 dpc have reduced alpha-feto-protein levels and reduced fucosylation of alpha-feto-protein. Belongs to the RbsD / FucU family. Sequence=BAE37468.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cellular_component monosaccharide metabolic process fucose metabolic process isomerase activity racemase and epimerase activity, acting on carbohydrates and derivatives fucosylation L-fucose mutarotase activity fucose binding negative regulation of neuron differentiation monosaccharide binding female mating behavior uc009kgu.1 uc009kgu.2 uc009kgu.3 uc009kgu.4 
ENSMUST00000026540.9 Prap1 ENSMUST00000026540.9 proline-rich acidic protein 1 (from RefSeq NM_009475.2) ENSMUST00000026540.1 ENSMUST00000026540.2 ENSMUST00000026540.3 ENSMUST00000026540.4 ENSMUST00000026540.5 ENSMUST00000026540.6 ENSMUST00000026540.7 ENSMUST00000026540.8 NM_009475 PRAP1_MOUSE Q60874 Q80XD8 Upa uc009kgt.1 uc009kgt.2 uc009kgt.3 uc009kgt.4 Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (PubMed:33168624). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (PubMed:32629119). May play an important role in maintaining normal growth homeostasis in epithelial cells (By similarity). Involved in p53/TP53-dependent cell survival after DNA damage (By similarity). Interacts with MTTP (PubMed:33168624). Interacts with MAD1L1 (By similarity). Secreted Endoplasmic reticulum Predominantly expressed in the intestinal epithelial cells than in the liver (at protein level) (PubMed:33168624, PubMed:32629119). Abundantly expressed in the uterus during late pregnancy by uterus epithelial cells. After birth expression rapidly decreases and is no longer found in the uterus by the third day. Also highly expressed in the small intestine where it shows a proximal- distal graded expression. Mice show an increase in the length of the small intestine (PubMed:33168624). Gain significantly less body weight and fat mass when on high-fat diets compared with littermate controls and are prevented from hepatosteatosis (PubMed:33168624). Show increased cytokine expression and altered gut microbiota, and are significantly more susceptible to oxidative insult by ionizing radiation, showing accelerated mortality and enterocyte apoptosis (PubMed:32629119). extracellular region uc009kgt.1 uc009kgt.2 uc009kgt.3 uc009kgt.4 
ENSMUST00000026547.9 Tubgcp2 ENSMUST00000026547.9 tubulin, gamma complex component 2, transcript variant 2 (from RefSeq NM_133755.2) ENSMUST00000026547.1 ENSMUST00000026547.2 ENSMUST00000026547.3 ENSMUST00000026547.4 ENSMUST00000026547.5 ENSMUST00000026547.6 ENSMUST00000026547.7 ENSMUST00000026547.8 G5E859 GCP2_MOUSE Gcp2 NM_133755 Q921G8 uc009kgl.1 uc009kgl.2 uc009kgl.3 uc009kgl.4 Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Plays a role in neuronal migration. Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Belongs to the TUBGCP family. microtubule cytoskeleton organization mitotic cell cycle spindle pole equatorial microtubule organizing center gamma-tubulin complex nucleoplasm cytoplasm centrosome microtubule organizing center cytoskeleton microtubule microtubule nucleation gamma-tubulin small complex cytoplasmic microtubule organization gamma-tubulin binding spindle assembly meiotic cell cycle interphase microtubule nucleation by interphase microtubule organizing center microtubule minus-end binding uc009kgl.1 uc009kgl.2 uc009kgl.3 uc009kgl.4 
ENSMUST00000026548.14 Adgra1 ENSMUST00000026548.14 adhesion G protein-coupled receptor A1 (from RefSeq NM_177469.3) AGRA1_MOUSE Adgra1 ENSMUST00000026548.1 ENSMUST00000026548.10 ENSMUST00000026548.11 ENSMUST00000026548.12 ENSMUST00000026548.13 ENSMUST00000026548.2 ENSMUST00000026548.3 ENSMUST00000026548.4 ENSMUST00000026548.5 ENSMUST00000026548.6 ENSMUST00000026548.7 ENSMUST00000026548.8 ENSMUST00000026548.9 Gpr123 NM_177469 Q8C4G9 Q8CC05 uc009kgb.1 uc009kgb.2 Membrane ; Multi-pass membrane protein Predominantly expressed in CNS. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. molecular_function transmembrane signaling receptor activity G-protein coupled receptor activity cell surface receptor signaling pathway G-protein coupled receptor signaling pathway biological_process postsynaptic density membrane integral component of membrane glutamatergic synapse uc009kgb.1 uc009kgb.2 
ENSMUST00000026551.15 Dpysl4 ENSMUST00000026551.15 dihydropyrimidinase-like 4 (from RefSeq NM_011993.4) Dpysl4 ENSMUST00000026551.1 ENSMUST00000026551.10 ENSMUST00000026551.11 ENSMUST00000026551.12 ENSMUST00000026551.13 ENSMUST00000026551.14 ENSMUST00000026551.2 ENSMUST00000026551.3 ENSMUST00000026551.4 ENSMUST00000026551.5 ENSMUST00000026551.6 ENSMUST00000026551.7 ENSMUST00000026551.8 ENSMUST00000026551.9 NM_011993 Q3TMU8 Q3TMU8_MOUSE uc009kfj.1 uc009kfj.2 uc009kfj.3 uc009kfj.4 uc009kfj.5 Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. cytoplasm hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds filamin binding neuron death neuron projection guidance uc009kfj.1 uc009kfj.2 uc009kfj.3 uc009kfj.4 uc009kfj.5 
ENSMUST00000026552.9 Cyp2e1 ENSMUST00000026552.9 cytochrome P450, family 2, subfamily e, polypeptide 1 (from RefSeq NM_021282.3) CP2E1_MOUSE Cyp2e Cyp2e-1 ENSMUST00000026552.1 ENSMUST00000026552.2 ENSMUST00000026552.3 ENSMUST00000026552.4 ENSMUST00000026552.5 ENSMUST00000026552.6 ENSMUST00000026552.7 ENSMUST00000026552.8 NM_021282 Q05421 Q9Z198 uc009kic.1 uc009kic.2 uc009kic.3 uc009kic.4 A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence=; Reaction=(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50076, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78043, ChEBI:CHEBI:132024; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50077; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)- eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39787, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76636; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39788; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)- docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50088, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:132025; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50089; Evidence=; Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39751, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76628; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39752; Evidence=; Reaction=O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50096, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30807, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132031; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50097; Evidence=; Reaction=4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+); Xref=Rhea:RHEA:26205, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57730, ChEBI:CHEBI:57783, ChEBI:CHEBI:57917, ChEBI:CHEBI:58349; EC=1.14.13.n7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26206; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; The omega-1 hydroxylase activity is stimulated by cytochrome b5. Lipid metabolism; fatty acid metabolism. Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria. Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Mitochondrion inner membrane ; Peripheral membrane protein Note=Post-translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein. Highest level in the liver and to a lesser extent in the kidney, with a higher level in the male kidney than in the female. Detectable in the female liver on day 1 and reaches steady state levels on days 16-20. By ethanol and acetone in the liver and by testosterone in the kidney and adrenal tissues. Belongs to the cytochrome P450 family. Golgi membrane lipid hydroxylation monooxygenase activity iron ion binding cytoplasm mitochondrion mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process lipid metabolic process fatty acid metabolic process triglyceride metabolic process xenobiotic metabolic process steroid metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity response to bacterium response to ozone response to organonitrogen compound membrane monoterpenoid metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen drug metabolic process 4-nitrophenol 2-monooxygenase activity 4-nitrophenol metabolic process epoxygenase P450 pathway enzyme binding heme binding Hsp70 protein binding organelle membrane intrinsic component of endoplasmic reticulum membrane response to drug exogenous drug catabolic process intracellular membrane-bounded organelle response to ethanol heterocycle metabolic process metal ion binding Hsp90 protein binding oxidation-reduction process aromatase activity uc009kic.1 uc009kic.2 uc009kic.3 uc009kic.4 
ENSMUST00000026553.6 Syce1 ENSMUST00000026553.6 synaptonemal complex central element protein 1 (from RefSeq NM_001143765.1) ENSMUST00000026553.1 ENSMUST00000026553.2 ENSMUST00000026553.3 ENSMUST00000026553.4 ENSMUST00000026553.5 NM_001143765 Q9D495 SYCE1_MOUSE uc009kid.1 uc009kid.2 uc009kid.3 uc009kid.4 Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:15944401). Requires SYCP1 in order to be incorporated into the central element (PubMed:15944401, PubMed:16968740). May have a role in the synaptonemal complex assembly, stabilization and recombination (PubMed:15944401). Homodimer (PubMed:15944401). Found in a complex with SYCP1 and SYCE2 (PubMed:15944401). Interacts with SYCP1, SYCE2 and SYCE3 (PubMed:15944401, PubMed:21637789, PubMed:16968740). Interacts with SIX6OS1 (PubMed:27796301). Q9D495; B5KM66: Syce3; NbExp=2; IntAct=EBI-6128757, EBI-6128737; Nucleus Chromosome Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements. Meiotic cells (at protein level). Expressed in the ovary and testis. Expressed in testis at 14 dpc and in oocytes at 18 dpc. Belongs to the SYCE family. synaptonemal complex central element protein binding nucleus nucleoplasm chromosome cell cycle synaptonemal complex assembly cell division meiotic cell cycle synaptonemal complex organization uc009kid.1 uc009kid.2 uc009kid.3 uc009kid.4 
ENSMUST00000026555.12 Cimap1a ENSMUST00000026555.12 ciliary microtubule associated protein 1A (from RefSeq NM_027019.3) Beta390 CMA1A_MOUSE ENSMUST00000026555.1 ENSMUST00000026555.10 ENSMUST00000026555.11 ENSMUST00000026555.2 ENSMUST00000026555.3 ENSMUST00000026555.4 ENSMUST00000026555.5 ENSMUST00000026555.6 ENSMUST00000026555.7 ENSMUST00000026555.8 ENSMUST00000026555.9 NM_027019 Odf3 Q920N1 Q9DAF2 Shippo1 uc009kih.1 uc009kih.2 uc009kih.3 Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail. Cytoplasm Cell projection, cilium, flagellum Note=Expressed in the cytoplasmic lobe of spermatids. Testis-specific (at protein level). Expression restricted to the germ cell fraction, absent in somatic cell fractions such as Sertoli and Leydig cells. Expression detected in the third week postpartum (23 days) after haploid germ cells developed, expression increased with age. Expressed in the tails of elongated spermatids sticking out toward the tubular lumen, and in cytoplasmic droplets still attached to the spermatid tail membrane. Expressed in the tails of mature sperm, from the connecting piece proximal to the head, along the middle and principal pieces, down to the distal end piece. 'Shippo' is a Japanese word for tail. Belongs to the CIMAP family. outer dense fiber molecular_function cytoplasm multicellular organism development spermatogenesis biological_process cell differentiation uc009kih.1 uc009kih.2 uc009kih.3 
ENSMUST00000026557.10 Bet1l ENSMUST00000026557.10 Bet1 golgi vesicular membrane trafficking protein like (from RefSeq NM_018742.5) BET1L_MOUSE Bet1l ENSMUST00000026557.1 ENSMUST00000026557.2 ENSMUST00000026557.3 ENSMUST00000026557.4 ENSMUST00000026557.5 ENSMUST00000026557.6 ENSMUST00000026557.7 ENSMUST00000026557.8 ENSMUST00000026557.9 Gs15 NM_018742 O35153 Q9D0E4 uc009kii.1 uc009kii.2 uc009kii.3 uc009kii.4 Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity). Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L. Golgi apparatus membrane ; Single- pass type IV membrane protein Golgi apparatus, trans- Golgi network membrane Note=Present throughout the Golgi apparatus, with increasing concentration from cis-Golgi to the trans- Golgi face of the stacks. Golgi trans cisterna Golgi membrane SNAP receptor activity endosome Golgi apparatus Golgi stack Golgi-associated vesicle trans-Golgi network cytosol protein transport membrane integral component of membrane integral component of Golgi membrane SNARE complex retrograde transport, endosome to Golgi membrane fusion regulation of retrograde vesicle-mediated transport, Golgi to ER uc009kii.1 uc009kii.2 uc009kii.3 uc009kii.4 
ENSMUST00000026558.7 Ric8a ENSMUST00000026558.7 RIC8 guanine nucleotide exchange factor A (from RefSeq NM_053194.4) ENSMUST00000026558.1 ENSMUST00000026558.2 ENSMUST00000026558.3 ENSMUST00000026558.4 ENSMUST00000026558.5 ENSMUST00000026558.6 NM_053194 Q3TEY3 Q3TIR3 Q99JW0 Q9ERR6 RIC8A_MOUSE Ric8 uc009kij.1 uc009kij.2 uc009kij.3 Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)- alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity). Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G- alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1. Interacts with NCS1; interaction is favored in the absence of Ca(2+) and myristoylation of NCS1 is not required (By similarity). Cytoplasm Cell membrane Note=Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). Colocalizes with RGS14 in CA2 hippocampal neurons. Expressed in neurons and neurites of the CA1 and CA2 subregions of the hippocampus (at protein level). In adult brain, it is expressed in the neocortex, hippocampus and cerebellum as well as in the pineal gland and ependymal layer. During the early development (9.5-12.0 dpc) it is expressed in the developing nervous system such as the cranial ganglia, neural tube, sympathetic chain and dorsal root ganglia. Also found in the lens, vomeronasal organ and endolymphatic sac. Death during early embryonic development. Heterozygous mice exhibit impaired spatial memory and decreased anxiety. Belongs to the synembryn family. in utero embryonic development vasculature development G-protein alpha-subunit binding guanyl-nucleotide exchange factor activity GTPase activator activity protein binding cytoplasm cytosol plasma membrane G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway gastrulation regulation of G-protein coupled receptor protein signaling pathway visual learning response to light stimulus membrane cell migration involved in gastrulation positive regulation of GTPase activity cell-cell adhesion involved in gastrulation basement membrane organization uc009kij.1 uc009kij.2 uc009kij.3 
ENSMUST00000026559.14 Sirt3 ENSMUST00000026559.14 sirtuin 3, transcript variant 1 (from RefSeq NM_022433.2) B9W0A9 C6ZII7 ENSMUST00000026559.1 ENSMUST00000026559.10 ENSMUST00000026559.11 ENSMUST00000026559.12 ENSMUST00000026559.13 ENSMUST00000026559.2 ENSMUST00000026559.3 ENSMUST00000026559.4 ENSMUST00000026559.5 ENSMUST00000026559.6 ENSMUST00000026559.7 ENSMUST00000026559.8 ENSMUST00000026559.9 NM_022433 Q8R104 Q9EPA8 SIR3_MOUSE Sir2l3 uc009kil.1 uc009kil.2 uc009kil.3 uc009kil.4 NAD-dependent protein deacetylase (PubMed:23835326, PubMed:17923681, PubMed:18794531, PubMed:21172655, PubMed:26620563). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:23835326, PubMed:17923681, PubMed:18794531, PubMed:21172655). Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16790548, PubMed:18794531, PubMed:21172655). Contributes to the regulation of the cellular energy metabolism (PubMed:23835326, PubMed:36804859). Important for regulating tissue-specific ATP levels (PubMed:18794531, PubMed:24252090). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (PubMed:26620563). Regulates hepatic lipogenesis. Uses NAD(+) substrate imported by SLC25A47, triggering downstream activation of PRKAA1/AMPK-alpha signaling cascade that ultimately downregulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286; Evidence= Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Upon metabolic stress, forms a complex composed of FOXO3, SIRT3 and mitochondrial RNA polymerase POLRMT; the complex is recruited to mtDNA in a SIRT3-dependent manner (PubMed:23283301). Also forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT (By similarity). Interacts with NDUFA9, ACSS1, IDH2 and GDH (By similarity). Interacts with PCCA (PubMed:23438705). Q8R104; P47738: Aldh2; NbExp=2; IntAct=EBI-6999888, EBI-2308120; [Isoform L]: Mitochondrion matrix [Isoform S]: Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=L; Synonyms=M1; IsoId=Q8R104-1; Sequence=Displayed; Name=S; Synonyms=M3; IsoId=Q8R104-2; Sequence=VSP_053760; Strongly expressed in liver and kidney (PubMed:11056054). Expressed in skeletal muscles (at protein level) (PubMed:23283301, PubMed:23835326). Weakly expressed in lung (PubMed:11056054). Sirt3 expression decreases by 50% in skeletal muscle upon fasting. Decreased muscle endurance under energetically demanding conditions (PubMed:24252090). Decreased Mn-SOD activity in liver, increased mitochondrial superoxide levels and genomic instability upon exposure to ionizing radiations (PubMed:21172655). In vivo ATP levels are reduced by 50 % in organs that normally express high levels of this protein (PubMed:18794531). ATP levels are unchanged in organs that normally express low levels of this protein (PubMed:18794531). Leads to increased mitochondrial protein acetylation (PubMed:18794531). Decreased ceramide accumulation in brain mitochondria (PubMed:26620563). Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is unlikely in vivo. Belongs to the sirtuin family. Class I subfamily. protein binding nucleus cytoplasm mitochondrion mitochondrial inner membrane mitochondrial matrix protein deacetylation zinc ion binding aerobic respiration membrane histone deacetylation hydrolase activity NAD-dependent histone deacetylase activity enzyme binding positive regulation of insulin secretion NAD-dependent histone deacetylase activity (H3-K14 specific) macromolecular complex NAD-dependent protein deacetylase activity peptidyl-lysine deacetylation sequence-specific DNA binding metal ion binding negative regulation of ERK1 and ERK2 cascade NAD+ binding histone H3 deacetylation positive regulation of transcription from mitochondrial promoter positive regulation of ceramide biosynthetic process negative regulation of reactive oxygen species metabolic process negative regulation of peptidyl-lysine acetylation uc009kil.1 uc009kil.2 uc009kil.3 uc009kil.4 
ENSMUST00000026560.14 Psmd13 ENSMUST00000026560.14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 (from RefSeq NM_011875.4) ENSMUST00000026560.1 ENSMUST00000026560.10 ENSMUST00000026560.11 ENSMUST00000026560.12 ENSMUST00000026560.13 ENSMUST00000026560.2 ENSMUST00000026560.3 ENSMUST00000026560.4 ENSMUST00000026560.5 ENSMUST00000026560.6 ENSMUST00000026560.7 ENSMUST00000026560.8 ENSMUST00000026560.9 NM_011875 PSD13_MOUSE Q3TB19 Q3TR74 Q542R0 Q9WVJ2 uc009kin.1 uc009kin.2 uc009kin.3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components. Belongs to the proteasome subunit S11 family. Sequence=BAE42495.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; proteasome complex endopeptidase activity structural molecule activity nucleus cytosol proteasome regulatory particle ubiquitin-dependent protein catabolic process meiosis I proteasome regulatory particle, lid subcomplex proteasome accessory complex proteasome assembly uc009kin.1 uc009kin.2 uc009kin.3 
ENSMUST00000026561.10 Cox8b ENSMUST00000026561.10 cytochrome c oxidase subunit 8B (from RefSeq NM_007751.3) Cox8b ENSMUST00000026561.1 ENSMUST00000026561.2 ENSMUST00000026561.3 ENSMUST00000026561.4 ENSMUST00000026561.5 ENSMUST00000026561.6 ENSMUST00000026561.7 ENSMUST00000026561.8 ENSMUST00000026561.9 NM_007751 Q545U6 Q545U6_MOUSE uc009kio.1 uc009kio.2 uc009kio.3 uc009kio.4 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Energy metabolism; oxidative phosphorylation. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Membrane ; Single- pass membrane protein Mitochondrion inner membrane ingle-pass membrane protein Belongs to the cytochrome c oxidase VIII family. cytochrome-c oxidase activity membrane integral component of membrane electron transport chain hydrogen ion transmembrane transport uc009kio.1 uc009kio.2 uc009kio.3 uc009kio.4 
ENSMUST00000026562.6 Ifitm5 ENSMUST00000026562.6 interferon induced transmembrane protein 5 (from RefSeq NM_053088.3) Bril ENSMUST00000026562.1 ENSMUST00000026562.2 ENSMUST00000026562.3 ENSMUST00000026562.4 ENSMUST00000026562.5 Fragilis4 IFM5_MOUSE NM_053088 O88728 uc009kiy.1 uc009kiy.2 uc009kiy.3 Required for normal bone mineralization. Interacts with FKBP11. Cell membrane ulti-pass membrane protein Detected in embryonic bone (at protein level) (PubMed:18442316). Highly expressed in osteoblasts of adults and embryos. Expressed in primitive hemopoietic cells. In embryos at 16.5 dpf, detected in lumbar and thoracic vertebra, the basisphenoid bone, the mandible, the coronal suture between the frontal and parietal bones, the maxilla, the nasal bone and the palate, as well as in the bone collars of long bones and digital bones in hind limbs, and in the primary ossification center. By interferons. Palmitoylated. Embryonic lethality, leading to the birth of only 7% homozygous mutant pups, instead of the expected 25%. Only two out of eight pups were female. Crossing homozygous mice gave rise to about one sixth of the normal litter size, and many newborns died within 48 hours after birth. Homozygous newborns display no striking phenotype other than smaller bones and especially shorter long bones, and this phenotype persists into adulthood. The radius, ulna and tibia are frequently bent in newborns, but this is no longer the case in young adults. Membrane topology is controversial. The N-terminus is cytoplasmic and the C-terminus extracellular according to PubMed:24715519, while both the N-terminus and the C-terminus are extracellular according to PubMed:18442316. Belongs to the CD225/Dispanin family. in utero embryonic development molecular_function plasma membrane integral component of plasma membrane multicellular organism development membrane integral component of membrane bone mineralization regulation of bone mineralization bone morphogenesis uc009kiy.1 uc009kiy.2 uc009kiy.3 
ENSMUST00000026565.7 Ifitm3 ENSMUST00000026565.7 interferon induced transmembrane protein 3 (from RefSeq NM_025378.2) ENSMUST00000026565.1 ENSMUST00000026565.2 ENSMUST00000026565.3 ENSMUST00000026565.4 ENSMUST00000026565.5 ENSMUST00000026565.6 IFM3_MOUSE Ifitm3 NM_025378 Q9CQW9 Q9D8L6 uc009kjc.1 uc009kjc.2 uc009kjc.3 IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein- mediated viral entry and VSV G protein-mediated viral entry (PubMed:33270927). Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v- ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation. IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome. Exerts opposing activities on SARS- CoV-2, including amphipathicity-dependent restriction of virus at endosomes and amphipathicity-independent enhancement of infection at the plasma membrane. Interacts with ATP6V0B (PubMed:22467717). Interacts with CD81 (PubMed:16395393). Interacts with SPP1; the interaction reduces OPN expression (By similarity). Interacts with BRI3 (By similarity). Cell membrane ; Single-pass type II membrane protein Late endosome membrane ; Single-pass type II membrane protein Early endosome membrane ; Single-pass type II membrane protein Lysosome membrane ; Single-pass type II membrane protein Cytoplasm, perinuclear region Note=Co-localizes with BRI3 isoform 1 at the perinuclear region. Expressed in acinar cell. Predominantly expressed in nascent primordial germ cells, as well as in gonadal germ cells. At 7.25 dpc strong expression is found at the base of the incipient allantois and weak expression in the mesodermal portion of the posterior amnion, and, importantly, the expression did not extend to the allantois. Expression persisted until the late bud stage (7.5 dpc), but gradually faded around the early head fold stage (7.75 dpc). At an earlier stage, only weak expression is seen throughout the epiblast in 6.0 dpc. But around 6.25-6.5 dpc (before gastrulation), marked expression is evident within the most proximal layer of the epiblast that is in intimate contact with the extraembryonic ectoderm. Expression is indeed induced by extraembryonic ectoderm through signaling molecules. During germ cell formation, is expressed in putative PGC ancestors in embryos at 6.5-7.5 dpc. In migrating PGCs, expression is continuous. After the beginning of gastrulation, the expression migrates to the posterior end of the developing primitive streak at the early/mid streak stage and became very intense in the position where PGCs (Primordial germ cells) differentiate from late streak stage onward. By alpha interferon. Induced in pancreas during caerulein- induced pancreatitis. Induced in pancreas under systemic- lipopolysaccharide treatment and in intestine under Salmonella infection. Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiquitination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site. Phosphorylation at Tyr-20 is required for endosomal and lysosomal location. Belongs to the CD225/Dispanin family. It has been previously shown that mediates migration of early primordial germ cells (PGCs) (PubMed:16326387). But according to PubMed:16326387, have no detectable effects on development of the germ line or on the generation of live young, hence, is not essential for PGC migration. immune system process nucleus cytoplasm lysosome lysosomal membrane endosome endoplasmic reticulum plasma membrane receptor-mediated endocytosis negative regulation of cell proliferation response to virus cell surface membrane integral component of membrane cytoplasmic vesicle late endosome membrane negative regulation of viral transcription macromolecular complex response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication innate immune response apical part of cell negative regulation of viral entry into host cell defense response to virus type I interferon signaling pathway uc009kjc.1 uc009kjc.2 uc009kjc.3 
ENSMUST00000026568.10 Ptdss2 ENSMUST00000026568.10 phosphatidylserine synthase 2, transcript variant 7 (from RefSeq NR_184743.1) ENSMUST00000026568.1 ENSMUST00000026568.2 ENSMUST00000026568.3 ENSMUST00000026568.4 ENSMUST00000026568.5 ENSMUST00000026568.6 ENSMUST00000026568.7 ENSMUST00000026568.8 ENSMUST00000026568.9 NR_184743 PTSS2_MOUSE Pss2 Q8BHL2 Q8CCI8 Q8CCY7 Q922A1 Q9CY68 Q9Z1X2 uc009kjq.1 uc009kjq.2 uc009kjq.3 Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:10432300, PubMed:10938271, PubMed:23071296, PubMed:12361952). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:10938271, PubMed:23071296). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (PubMed:23071296). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (PubMed:23071296). Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine; Xref=Rhea:RHEA:27606, ChEBI:CHEBI:33384, ChEBI:CHEBI:57262, ChEBI:CHEBI:57603, ChEBI:CHEBI:64612; EC=2.7.8.29; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27607; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)- sn-glycero-3-phospho-L-serine + ethanolamine; Xref=Rhea:RHEA:41484, ChEBI:CHEBI:33384, ChEBI:CHEBI:57603, ChEBI:CHEBI:73007, ChEBI:CHEBI:75029; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41485; Evidence=; Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2- (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine; Xref=Rhea:RHEA:41488, ChEBI:CHEBI:33384, ChEBI:CHEBI:57603, ChEBI:CHEBI:78261, ChEBI:CHEBI:78262; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41489; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero- 3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine; Xref=Rhea:RHEA:41500, ChEBI:CHEBI:33384, ChEBI:CHEBI:57603, ChEBI:CHEBI:78268, ChEBI:CHEBI:78269; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41501; Evidence=; Reaction=1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2- (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine; Xref=Rhea:RHEA:41492, ChEBI:CHEBI:33384, ChEBI:CHEBI:57603, ChEBI:CHEBI:78265, ChEBI:CHEBI:78266; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41493; Evidence=; Reaction=1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)- sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2- (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine; Xref=Rhea:RHEA:41496, ChEBI:CHEBI:33384, ChEBI:CHEBI:57603, ChEBI:CHEBI:78263, ChEBI:CHEBI:78264; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41497; Evidence=; Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)- sn-glycero-3-phospho-L-serine + ethanolamine; Xref=Rhea:RHEA:40795, ChEBI:CHEBI:33384, ChEBI:CHEBI:57603, ChEBI:CHEBI:75038, ChEBI:CHEBI:78260; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40796; Evidence=; Reaction=1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z- octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine; Xref=Rhea:RHEA:41600, ChEBI:CHEBI:33384, ChEBI:CHEBI:57603, ChEBI:CHEBI:78340, ChEBI:CHEBI:78341; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41601; Evidence=; Reaction=1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn- glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine; Xref=Rhea:RHEA:41604, ChEBI:CHEBI:33384, ChEBI:CHEBI:57603, ChEBI:CHEBI:78342, ChEBI:CHEBI:78343; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41605; Evidence=; Almost complete inhibition by ethanolamine in both the mitochondria-associated membrane (MAM) and endoplasmic reticulum (ER) per se. Phospholipid metabolism; phosphatidylserine biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane Note=Highly enriched in the mitochondria-associated membrane (MAM). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z1X2-1; Sequence=Displayed; Name=2; IsoId=Q9Z1X2-2; Sequence=VSP_010637, VSP_010638; Highly expressed in testis. Detected at lower levels in kidney and heart. Null mice exhibit a reduction of more than 95% in serine exchange in testis and approximately 90% reduction in brain and liver. Testis weight is reduced and some animals are infertile. Elimination of either Pss1 or Pss2, but not both, is compatible with mouse viability. Mice can tolerate as little as 10% serine-exchange activity and are viable with small amounts of phosphatidylserine and phosphatidylethanolamine content. Belongs to the phosphatidyl serine synthase family. CDP-diacylglycerol-serine O-phosphatidyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phosphatidylserine biosynthetic process phospholipid biosynthetic process membrane integral component of membrane transferase activity uc009kjq.1 uc009kjq.2 uc009kjq.3 
ENSMUST00000026569.6 Drd4 ENSMUST00000026569.6 dopamine receptor D4, transcript variant 1 (from RefSeq NM_007878.4) DRD4_MOUSE ENSMUST00000026569.1 ENSMUST00000026569.2 ENSMUST00000026569.3 ENSMUST00000026569.4 ENSMUST00000026569.5 NM_007878 O35838 P51436 Q7TT80 Q8BXS4 uc009kkm.1 uc009kkm.2 uc009kkm.3 Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (By similarity). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (PubMed:24048828). Forms homo- and heterooligomers with DRD2. D4.7 allele exhibits higher affinity for homodimers compared to DRD2 heterodimers, while alleles D42. and 4.4 have similar affinities for both. The interaction with DRD2 may modulate agonist-induced downstream signaling (By similarity). Interacts with CLIC6 (By similarity). Interacts with GPRASP1. May interact with ADORA2A. Interacts with KLHL12 (By similarity). Cell membrane ; Multi-pass membrane protein Detected in olfactory bulb, hypothalamus, olfactory tubercle, brainstem and striatum. Palmitoylated. Palmitoylation of the C-terminal Cys is important for normal expression at the cell membrane. Mice show a significant reduction in daytime contrast sensitivity. Belongs to the G-protein coupled receptor 1 family. In contrast to human protein, does not interact with KLHL12 and is not ubiquitinated by the BCR(KLHL12) complex. activation of MAPK activity dopamine neurotransmitter receptor activity, coupled via Gi/Go behavioral fear response synaptic transmission, dopaminergic response to amphetamine G-protein coupled receptor activity dopamine neurotransmitter receptor activity G-protein coupled serotonin receptor activity cytoplasm plasma membrane integral component of plasma membrane cell cortex signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting dopamine receptor signaling pathway dopamine receptor signaling pathway chemical synaptic transmission short-term memory drug binding associative learning adult locomotory behavior olfactory learning vesicle membrane membrane integral component of membrane SH3 domain binding axon dendrite neurotransmitter receptor activity positive regulation of sodium:proton antiporter activity positive regulation of kinase activity response to histamine dopamine binding regulation of dopamine metabolic process fear response regulation of circadian rhythm identical protein binding neuronal cell body terminal bouton dendritic spine axon terminus metal ion binding regulation of neurotransmitter secretion behavioral response to cocaine rhythmic process arachidonic acid secretion negative regulation of protein secretion modulation of synaptic transmission regulation of calcium-mediated signaling epinephrine binding norepinephrine binding inhibitory postsynaptic potential positive regulation of penile erection glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane regulation of postsynaptic specialization membrane neurotransmitter receptor levels negative regulation of voltage-gated calcium channel activity negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration regulation of synaptic vesicle exocytosis positive regulation of excitatory postsynaptic potential uc009kkm.1 uc009kkm.2 uc009kkm.3 
ENSMUST00000026571.11 Irf7 ENSMUST00000026571.11 interferon regulatory factor 7, transcript variant 1 (from RefSeq NM_016850.3) ENSMUST00000026571.1 ENSMUST00000026571.10 ENSMUST00000026571.2 ENSMUST00000026571.3 ENSMUST00000026571.4 ENSMUST00000026571.5 ENSMUST00000026571.6 ENSMUST00000026571.7 ENSMUST00000026571.8 ENSMUST00000026571.9 Irf7 NM_016850 Q542T3 Q542T3_MOUSE uc009kkg.1 uc009kkg.2 uc009kkg.3 uc009kkg.4 RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding regulation of adaptive immune response DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated positive regulation of interferon-alpha production positive regulation of interferon-beta production transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter defense response to virus uc009kkg.1 uc009kkg.2 uc009kkg.3 uc009kkg.4 
ENSMUST00000026572.11 Hras ENSMUST00000026572.11 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (from UniProt Q61411) BC061885 ENSMUST00000026572.1 ENSMUST00000026572.10 ENSMUST00000026572.2 ENSMUST00000026572.3 ENSMUST00000026572.4 ENSMUST00000026572.5 ENSMUST00000026572.6 ENSMUST00000026572.7 ENSMUST00000026572.8 ENSMUST00000026572.9 F7BIB2 Hras1 Q61411 Q6P716 Q80WD2 Q811B9 RASH_MOUSE uc009kju.1 uc009kju.2 uc009kju.3 uc009kju.4 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide- exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Forms a signaling complex with RASGRP1 and DGKZ (By similarity). In its GTP-bound form interacts with PLCE1 (By similarity). Interacts with TBC1D10C and RASSF5 (By similarity). Interacts with PDE6D (By similarity). Interacts with IKZF3 (By similarity). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14 (By similarity). Interacts (active GTP-bound form) with RGS14 (via RBD 1 domain) (By similarity). Interacts with RACK1 (By similarity). Interacts with RAPGEF2 (By similarity). Interacts with RGL3 (PubMed:10869344). Interacts with HSPD1 (PubMed:1347942). Interacts with PIK3CG; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (PubMed:19906996). Interacts (in GTP- bound form) with Oog1 (PubMed:16580637). Q61411; Q5EBH1: Rassf5; NbExp=2; IntAct=EBI-400273, EBI-960530; Cell membrane Cell membrane ; Lipid-anchor ; Cytoplasmic side Golgi apparatus Golgi apparatus membrane ; Lipid-anchor Note=Shuttles between the plasma membrane and the Golgi apparatus. The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=p21, H-Ras4A; IsoId=Q61411-1; Sequence=Displayed; Name=2; Synonyms=p19, H-RasIDX; IsoId=Q61411-2; Sequence=VSP_041598; Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi. S-nitrosylated; critical for redox regulation. Important for stimulating guanine nucleotide exchange. No structural perturbation on nitrosylation. The covalent modification of cysteine by 15-deoxy-Delta12,14- prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation. Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs). Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes. Belongs to the small GTPase superfamily. Ras family. Sequence=AAH61885.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane nucleotide binding positive regulation of protein phosphorylation GTPase activity protein binding GTP binding Golgi apparatus plasma membrane endocytosis apoptotic process cell cycle arrest mitotic cell cycle checkpoint signal transduction small GTPase mediated signal transduction Ras protein signal transduction cell aging protein C-terminus binding positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression positive regulation of phospholipase C activity membrane GDP binding positive regulation of cell migration positive regulation of interferon-gamma production negative regulation of GTPase activity response to isolation stress T-helper 1 type immune response defense response to protozoan intracellular membrane-bounded organelle positive regulation of MAP kinase activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of DNA replication positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of Ras protein signal transduction regulation of long-term neuronal synaptic plasticity positive regulation of epithelial cell proliferation T cell receptor signaling pathway protein heterooligomerization positive regulation of ERK1 and ERK2 cascade cellular response to gamma radiation positive regulation of wound healing positive regulation of protein targeting to membrane cellular senescence intrinsic apoptotic signaling pathway glutamatergic synapse positive regulation of ruffle assembly positive regulation of actin cytoskeleton reorganization positive regulation of miRNA metabolic process uc009kju.1 uc009kju.2 uc009kju.3 uc009kju.4 
ENSMUST00000026576.5 Taldo1 ENSMUST00000026576.5 transaldolase 1 (from RefSeq NM_011528.4) ENSMUST00000026576.1 ENSMUST00000026576.2 ENSMUST00000026576.3 ENSMUST00000026576.4 NM_011528 P70358 P70703 Q52KM4 Q93092 TALDO_MOUSE Tal Taldo uc009kkv.1 uc009kkv.2 uc009kkv.3 uc009kkv.4 This gene encodes a key enzyme of the nonoxidative pentose phosphate pathway that provides ribose-5-phosphate for nucleic acid synthesis and nicotinamide adenine dinucleotide phosphate (NADPH) for lipid biosynthesis. The encoded protein is important for maintaining structure and function of mitochondria. Studies in knockout mice identify that deficiency of this gene product is a cause of sperm dysmotility and male infertility. Deficiency of this protein has also been identified as a cause of hepatocarcinogenesis in mice. Two related pseudogenes have been identified on chromosome 10. [provided by RefSeq, Mar 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK003092.1, AK142030.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:17003133, PubMed:27703206). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (PubMed:27703206). Reaction=D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate; Xref=Rhea:RHEA:17053, ChEBI:CHEBI:16897, ChEBI:CHEBI:57483, ChEBI:CHEBI:57634, ChEBI:CHEBI:59776; EC=2.2.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17054; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17055; Evidence=; Carbohydrate degradation; pentose phosphate pathway; D- glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D- ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. Homodimer (PubMed:27703206). Heterodimer with isoform 2 (PubMed:27703206). Interacts with KPNA1 and KPNA4 (PubMed:27703206). [Isoform 1]: Nucleus Cytoplasm Note=Shuttles between the nucleus and the cytoplasm. Actively transported into the nucleus in an importin alpha/beta-dependent manner (PubMed:27703206). Exported into the cytoplasm by CRM1 (PubMed:27703206). [Isoform 2]: Cytoplasm Note=Imported into the nucleus when incorporated in isoform 1/isoform 2 homodimer. Event=Alternative initiation; Named isoforms=2; Name=1; Synonyms=TALDO1L ; IsoId=Q93092-1; Sequence=Displayed; Name=2; Synonyms=TALDO1S ; IsoId=Q93092-2; Sequence=VSP_061596; The first 10 amino acids are essential for nuclear localization. Deficient mice develop normally; however, males are sterile because of functional and structural defects of mitochondria (PubMed:17003133). Mice spontaneously develop hepatocellular carcinoma. The liver of these mice present an accumulation of five-carbon sugarphosphates and a depletion of NADPH and GSH (PubMed:19436114). Belongs to the transaldolase family. Type 1 subfamily. Sequence=AAB08722.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; catalytic activity sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity nucleus nucleoplasm cytoplasm cytosol carbohydrate metabolic process fructose 6-phosphate metabolic process pentose-phosphate shunt pentose-phosphate shunt, non-oxidative branch transferase activity glyceraldehyde-3-phosphate metabolic process carbohydrate binding intracellular membrane-bounded organelle monosaccharide binding uc009kkv.1 uc009kkv.2 uc009kkv.3 uc009kkv.4 
ENSMUST00000026577.13 Eps8l2 ENSMUST00000026577.13 EPS8-like 2 (from RefSeq NM_133191.3) ENSMUST00000026577.1 ENSMUST00000026577.10 ENSMUST00000026577.11 ENSMUST00000026577.12 ENSMUST00000026577.2 ENSMUST00000026577.3 ENSMUST00000026577.4 ENSMUST00000026577.5 ENSMUST00000026577.6 ENSMUST00000026577.7 ENSMUST00000026577.8 ENSMUST00000026577.9 ES8L2_MOUSE Eps8r2 NM_133191 Q91VT7 Q99K30 uc009kkt.1 uc009kkt.2 uc009kkt.3 Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells (PubMed:23918390). Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin (By similarity). Cytoplasm Cell projection, stereocilium Note=Localizes at the tips of the stereocilia of the inner and outer hair cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99K30-1; Sequence=Displayed; Name=2; IsoId=Q99K30-2; Sequence=VSP_019093, VSP_019094; Detected in fetal kidney, adrenal gland, salivary gland, stomach, gut, cartilage and skin. Detected in adult ovary, placenta, skin, adrenal gland, salivary gland, kidney, intestine and stomach. Expressed at the tips of cochlear hair cells stereocilia (PubMed:23918390). Mutant animal have a progressive and severe hearing loss at young adulthood (PubMed:23918390). The generation of receptor potentials in hair cells at lower sound pressure is impaired, which leads to a reduction in auditory nerve responses (PubMed:23918390). Belongs to the EPS8 family. ruffle actin binding Rho guanyl-nucleotide exchange factor activity cytoplasm cytosol plasma membrane Rho protein signal transduction sensory perception of sound Rac protein signal transduction Rac guanyl-nucleotide exchange factor activity stereocilium stereocilium bundle stereocilium tip ruffle membrane macromolecular complex regulation of Rho protein signal transduction cell projection actin filament binding positive regulation of ruffle assembly uc009kkt.1 uc009kkt.2 uc009kkt.3 
ENSMUST00000026578.14 Tmem80 ENSMUST00000026578.14 transmembrane protein 80, transcript variant 4 (from RefSeq NM_001374020.2) ENSMUST00000026578.1 ENSMUST00000026578.10 ENSMUST00000026578.11 ENSMUST00000026578.12 ENSMUST00000026578.13 ENSMUST00000026578.2 ENSMUST00000026578.3 ENSMUST00000026578.4 ENSMUST00000026578.5 ENSMUST00000026578.6 ENSMUST00000026578.7 ENSMUST00000026578.8 ENSMUST00000026578.9 NM_001374020 Q8BQL4 Q9D3H0 TMM80_MOUSE uc009kkr.1 uc009kkr.2 uc009kkr.3 uc009kkr.4 Membrane ; Multi-pass membrane protein Cell projection, cilium Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D3H0-1; Sequence=Displayed; Name=2; IsoId=Q9D3H0-2; Sequence=VSP_025611; molecular_function cilium membrane integral component of membrane ciliary transition zone cell projection non-motile cilium assembly uc009kkr.1 uc009kkr.2 uc009kkr.3 uc009kkr.4 
ENSMUST00000026580.12 Pidd1 ENSMUST00000026580.12 p53 induced death domain protein 1, transcript variant 4 (from RefSeq NR_153591.1) A6H6F4 ENSMUST00000026580.1 ENSMUST00000026580.10 ENSMUST00000026580.11 ENSMUST00000026580.2 ENSMUST00000026580.3 ENSMUST00000026580.4 ENSMUST00000026580.5 ENSMUST00000026580.6 ENSMUST00000026580.7 ENSMUST00000026580.8 ENSMUST00000026580.9 Lrdd NR_153591 PIDD1_MOUSE Pidd Pidd1 Q9ERV7 uc009klc.1 uc009klc.2 uc009klc.3 Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (By similarity). Forms a complex named the PIDDosome with CASP2 and CRADD (PubMed:22279524). Forms a complex with IKBKG and RIPK1. Interacts with FADD and MADD (By similarity). Cytoplasm Nucleus Note=Enriched in the nucleus upon DNA damage. Ubiquitous. Induced by TP53/tumor suppressor p53 and gamma-irradiation. The Death domain mediates the interaction with CRADD and the formation of a complex composed of 5 PIDD1 and 7 CRADD proteins which in turn recruit 7 CASP2 to form the PIDDosome. The LRR repeat-containing domain has a regulatory activity, being autoinhibitory for the activation of NF-kappa-B. Undergoes autoproteolytic processing whose extent either directs cells towards survival or apoptotic pathways. Autoproteolytically cleaved into two main fragments PIDD-N and PIDD-C. PIDD-C can be further processed into PIDD-CC, a processing which is enhanced by DNA damage. The cleavage producing PIDD-C is required for translocation of PIDD1 to the nucleus upon DNA damage and activation of NF-kappa-B. PIDD-CC mediates the interaction with CRADD and the cleavage producing PIDD-CC is required for the activation of CASP2. PIDD-N remains associated with PIDD-C and PIDD-CC after cleavage. endopeptidase activity protein binding nucleus cytoplasm Golgi apparatus cytosol apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest signal transduction extrinsic apoptotic signaling pathway via death domain receptors protein autoprocessing hydrolase activity negative regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling apoptotic signaling pathway extrinsic apoptotic signaling pathway uc009klc.1 uc009klc.2 uc009klc.3 
ENSMUST00000026585.14 Tspan4 ENSMUST00000026585.14 tetraspanin 4, transcript variant 1 (from RefSeq NM_053082.4) ENSMUST00000026585.1 ENSMUST00000026585.10 ENSMUST00000026585.11 ENSMUST00000026585.12 ENSMUST00000026585.13 ENSMUST00000026585.2 ENSMUST00000026585.3 ENSMUST00000026585.4 ENSMUST00000026585.5 ENSMUST00000026585.6 ENSMUST00000026585.7 ENSMUST00000026585.8 ENSMUST00000026585.9 NM_053082 Q9DCK3 TSN4_MOUSE Tm4sf7 uc009kln.1 uc009kln.2 uc009kln.3 uc009kln.4 Forms a complex with integrins. Membrane; Multi-pass membrane protein. Belongs to the tetraspanin (TM4SF) family. antigen binding integrin binding protein binding plasma membrane integral component of plasma membrane membrane integral component of membrane vesicle macromolecular complex assembly uc009kln.1 uc009kln.2 uc009kln.3 uc009kln.4 
ENSMUST00000026595.13 Tmem192 ENSMUST00000026595.13 transmembrane protein 192, transcript variant 1 (from RefSeq NM_028427.3) ENSMUST00000026595.1 ENSMUST00000026595.10 ENSMUST00000026595.11 ENSMUST00000026595.12 ENSMUST00000026595.2 ENSMUST00000026595.3 ENSMUST00000026595.4 ENSMUST00000026595.5 ENSMUST00000026595.6 ENSMUST00000026595.7 ENSMUST00000026595.8 ENSMUST00000026595.9 NM_028427 Q3THT5 Q8VDU8 Q9CXT7 TM192_MOUSE uc009lvb.1 uc009lvb.2 uc009lvb.3 uc009lvb.4 uc009lvb.5 uc009lvb.6 Homodimer. Lysosome membrane ; Multi-pass membrane protein Late endosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CXT7-1; Sequence=Displayed; Name=2; IsoId=Q9CXT7-2; Sequence=VSP_029503; Belongs to the TMEM192 family. nucleoplasm lysosome lysosomal membrane endosome late endosome biological_process membrane integral component of membrane protein homodimerization activity perinuclear region of cytoplasm uc009lvb.1 uc009lvb.2 uc009lvb.3 uc009lvb.4 uc009lvb.5 uc009lvb.6 
ENSMUST00000026599.10 Apool ENSMUST00000026599.10 apolipoprotein O-like, transcript variant 1 (from RefSeq NM_026565.3) ENSMUST00000026599.1 ENSMUST00000026599.2 ENSMUST00000026599.3 ENSMUST00000026599.4 ENSMUST00000026599.5 ENSMUST00000026599.6 ENSMUST00000026599.7 ENSMUST00000026599.8 ENSMUST00000026599.9 Fam121a MIC27_MOUSE Mic27 NM_026565 Q78IK4 uc009udh.1 uc009udh.2 uc009udh.3 uc009udh.4 Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with MICOS10/MIC10, IMMT/MIC60 and APOO/MIC23/MIC26. Mitochondrion inner membrane ; Multi-pass membrane protein Mitochondrion Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family. mitochondrion mitochondrial inner membrane membrane integral component of membrane cristae formation MICOS complex uc009udh.1 uc009udh.2 uc009udh.3 uc009udh.4 
ENSMUST00000026601.3 Satl1 ENSMUST00000026601.3 spermidine/spermine N1-acetyl transferase-like 1 (from RefSeq NM_028655.1) B9EHI8 ENSMUST00000026601.1 ENSMUST00000026601.2 NM_028655 Q9D5N8 SATL1_MOUSE uc009udi.1 uc009udi.2 uc009udi.3 Belongs to the acetyltransferase family. Sequence=BAB29707.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; diamine N-acetyltransferase activity cytosol N-acetyltransferase activity transferase activity transferase activity, transferring acyl groups spermidine binding spermidine acetylation uc009udi.1 uc009udi.2 uc009udi.3 
ENSMUST00000026607.15 Chm ENSMUST00000026607.15 CHM Rab escort protein, transcript variant 16 (from RefSeq NR_176884.1) A2AD03 A2AD03_MOUSE Chm ENSMUST00000026607.1 ENSMUST00000026607.10 ENSMUST00000026607.11 ENSMUST00000026607.12 ENSMUST00000026607.13 ENSMUST00000026607.14 ENSMUST00000026607.2 ENSMUST00000026607.3 ENSMUST00000026607.4 ENSMUST00000026607.5 ENSMUST00000026607.6 ENSMUST00000026607.7 ENSMUST00000026607.8 ENSMUST00000026607.9 NR_176884 uc009udn.1 uc009udn.2 uc009udn.3 Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Cytoplasm Belongs to the Rab GDI family. GDP-dissociation inhibitor activity GTPase activator activity cytoplasm cytosol Rab-protein geranylgeranyltransferase complex protein targeting to membrane intracellular protein transport small GTPase mediated signal transduction Rab GTPase binding protein geranylgeranylation positive regulation of GTPase activity regulation of catalytic activity uc009udn.1 uc009udn.2 uc009udn.3 
ENSMUST00000026608.11 Crcp ENSMUST00000026608.11 calcitonin gene-related peptide-receptor component protein (from RefSeq NM_007761.2) Crcp ENSMUST00000026608.1 ENSMUST00000026608.10 ENSMUST00000026608.2 ENSMUST00000026608.3 ENSMUST00000026608.4 ENSMUST00000026608.5 ENSMUST00000026608.6 ENSMUST00000026608.7 ENSMUST00000026608.8 ENSMUST00000026608.9 NM_007761 O35427 RPC9_MOUSE uc008zua.1 uc008zua.2 uc008zua.3 uc008zua.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity). Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3- POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Nucleus Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Ubiquitous. Most prevalent in testis. Belongs to the eukaryotic RPC9 RNA polymerase subunit family. nucleotide binding calcitonin gene-related peptide receptor activity acrosomal vesicle immune system process catalytic activity DNA-directed 5'-3' RNA polymerase activity cell nucleus DNA-directed RNA polymerase III complex cytoplasm plasma membrane DNA-templated transcription, initiation transcription from RNA polymerase III promoter transcription initiation from RNA polymerase III promoter neuropeptide signaling pathway DNA polymerase III complex membrane axon dendrite RNA polymerase complex neuronal cell body cellular metabolic process innate immune response defense response to virus RNA polymerase III activity uc008zua.1 uc008zua.2 uc008zua.3 uc008zua.4 
ENSMUST00000026613.14 Gusb ENSMUST00000026613.14 glucuronidase, beta, transcript variant 1 (from RefSeq NM_010368.2) BGLR_MOUSE ENSMUST00000026613.1 ENSMUST00000026613.10 ENSMUST00000026613.11 ENSMUST00000026613.12 ENSMUST00000026613.13 ENSMUST00000026613.2 ENSMUST00000026613.3 ENSMUST00000026613.4 ENSMUST00000026613.5 ENSMUST00000026613.6 ENSMUST00000026613.7 ENSMUST00000026613.8 ENSMUST00000026613.9 Gus Gus-s NM_010368 P12265 Q61601 Q64473 Q64474 Q6IR10 uc008ztt.1 uc008ztt.2 uc008ztt.3 Plays an important role in the degradation of dermatan and keratan sulfates. Reaction=a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate; Xref=Rhea:RHEA:17633, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:58720, ChEBI:CHEBI:83411; EC=3.2.1.31; Inhibited by L-aspartic acid. Homotetramer. Lysosome Endoplasmic reticulum Note=A small proportion is found in the endoplasmic reticulum. Belongs to the glycosyl hydrolase 2 family. hydrolase activity, hydrolyzing O-glycosyl compounds beta-glucuronidase activity receptor binding extracellular space lysosome endoplasmic reticulum carbohydrate metabolic process metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds glucuronoside catabolic process protein domain specific binding carbohydrate binding intracellular membrane-bounded organelle uc008ztt.1 uc008ztt.2 uc008ztt.3 
ENSMUST00000026617.13 Phkg1 ENSMUST00000026617.13 phosphorylase kinase gamma 1 (from RefSeq NR_145487.1) ENSMUST00000026617.1 ENSMUST00000026617.10 ENSMUST00000026617.11 ENSMUST00000026617.12 ENSMUST00000026617.2 ENSMUST00000026617.3 ENSMUST00000026617.4 ENSMUST00000026617.5 ENSMUST00000026617.6 ENSMUST00000026617.7 ENSMUST00000026617.8 ENSMUST00000026617.9 NR_145487 P07934 PHKG1_MOUSE Phkg uc008ztm.1 uc008ztm.2 uc008ztm.3 Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). Reaction=2 ATP + phosphorylase b = 2 ADP + phosphorylase a.; EC=2.7.11.19; Reaction=ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl- [tau protein]; Xref=Rhea:RHEA:12801, Rhea:RHEA-COMP:13701, Rhea:RHEA- COMP:13702, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.26; Reaction=ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L- threonyl-[tau protein]; Xref=Rhea:RHEA:53904, Rhea:RHEA-COMP:13703, Rhea:RHEA-COMP:13704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.26; Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. The two calmodulin-binding domains appear to act in concert to bind a single molecule of calmodulin and are pseudosubstrate/autoinhibitory domains. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity phosphorylase kinase activity calmodulin binding ATP binding phosphorylase kinase complex carbohydrate metabolic process glycogen metabolic process glycogen biosynthetic process protein phosphorylation kinase activity phosphorylation transferase activity enzyme binding tau-protein kinase activity uc008ztm.1 uc008ztm.2 uc008ztm.3 
ENSMUST00000026624.11 Tm9sf2 ENSMUST00000026624.11 transmembrane 9 superfamily member 2 (from RefSeq NM_080556.3) ENSMUST00000026624.1 ENSMUST00000026624.10 ENSMUST00000026624.2 ENSMUST00000026624.3 ENSMUST00000026624.4 ENSMUST00000026624.5 ENSMUST00000026624.6 ENSMUST00000026624.7 ENSMUST00000026624.8 ENSMUST00000026624.9 NM_080556 Q542E4 Q542E4_MOUSE Tm9sf2 uc007vaw.1 uc007vaw.2 uc007vaw.3 Membrane ; Multi- pass membrane protein Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. membrane integral component of membrane uc007vaw.1 uc007vaw.2 uc007vaw.3 
ENSMUST00000026625.7 Clybl ENSMUST00000026625.7 citrate lyase beta like (from RefSeq NM_029556.3) CLYBL_MOUSE Clb Clybl ENSMUST00000026625.1 ENSMUST00000026625.2 ENSMUST00000026625.3 ENSMUST00000026625.4 ENSMUST00000026625.5 ENSMUST00000026625.6 NM_029556 Q8R4N0 Q9D7D0 uc007vax.1 uc007vax.2 uc007vax.3 uc007vax.4 Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (By similarity). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (By similarity). Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl- CoA to beta-methylmalate (By similarity). Also has very weak citramalate synthase activity in vitro (By similarity). Reaction=acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+); Xref=Rhea:RHEA:18181, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589, ChEBI:CHEBI:36655, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.3.9; Evidence=; Reaction=glyoxylate + H2O + propanoyl-CoA = 3-methylmalate + CoA + H(+); Xref=Rhea:RHEA:47628, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:36655, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392, ChEBI:CHEBI:87810; Evidence=; Reaction=(3S)-citramalyl-CoA = acetyl-CoA + pyruvate; Xref=Rhea:RHEA:22612, ChEBI:CHEBI:15361, ChEBI:CHEBI:57288, ChEBI:CHEBI:58668; EC=4.1.3.25; Evidence=; Reaction=(S)-malyl-CoA + H2O = (S)-malate + CoA + H(+); Xref=Rhea:RHEA:38291, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589, ChEBI:CHEBI:57287, ChEBI:CHEBI:57317; EC=3.1.2.30; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Homotrimer. Mitochondrion Detected in brown fat, brain, liver, kidney, heart, skeletal muscle and ovary (at protein level). Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily. This organism lacks the other subunits that are necessary for ATP-independent citrate lyase activity. Even though this protein has clear similarity to citrate lyase beta subunit, it is expected to have a somewhat different enzyme activity. magnesium ion binding catalytic activity malate synthase activity mitochondrion transferase activity hydrolase activity lyase activity metal ion binding (3S)-citramalyl-CoA lyase activity protein homotrimerization uc007vax.1 uc007vax.2 uc007vax.3 uc007vax.4 
ENSMUST00000026631.6 Fgf14 ENSMUST00000026631.6 fibroblast growth factor 14, transcript variant 1 (from RefSeq NM_010201.5) A0A0R4J063 A0A0R4J063_MOUSE ENSMUST00000026631.1 ENSMUST00000026631.2 ENSMUST00000026631.3 ENSMUST00000026631.4 ENSMUST00000026631.5 Fgf14 Fgf1b NM_010201 uc007vbv.1 uc007vbv.2 uc007vbv.3 uc007vbv.4 Belongs to the heparin-binding growth factors family. extracellular region signal transduction nervous system development growth factor activity uc007vbv.1 uc007vbv.2 uc007vbv.3 uc007vbv.4 
ENSMUST00000026635.8 Farp1 ENSMUST00000026635.8 FERM, ARH/RhoGEF and pleckstrin domain protein 1, transcript variant 1 (from RefSeq NM_134082.4) C4IXU2 ENSMUST00000026635.1 ENSMUST00000026635.2 ENSMUST00000026635.3 ENSMUST00000026635.4 ENSMUST00000026635.5 ENSMUST00000026635.6 ENSMUST00000026635.7 F8VPU2 FARP1_MOUSE NM_134082 uc007vaa.1 uc007vaa.2 uc007vaa.3 Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). Interacts with CADM1. Interacts with RAC1 (By similarity). Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Synapse Synapse, synaptosome Cytoplasm, cytosol Cell projection, filopodium Cell projection, dendrite Cell projection, dendritic spine Note=Recruited to the cell membrane via interaction with CADM1. Detected in brain cortex, hippocampus, striatum, olfactory bulb, cerebellum and hindbrain (at protein level). Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation. guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cytoplasm cytosol cytoskeleton plasma membrane multicellular organism development synapse assembly cytoskeletal protein binding negative regulation of phosphatase activity membrane cell junction filopodium dendrite Rac guanyl-nucleotide exchange factor activity extrinsic component of cytoplasmic side of plasma membrane regulation of Rho protein signal transduction cell projection neuron projection dendritic spine synapse Rac GTPase binding dendrite morphogenesis extrinsic component of postsynaptic membrane retrograde trans-synaptic signaling by trans-synaptic protein complex postsynaptic actin cytoskeleton organization glutamatergic synapse regulation of presynapse assembly uc007vaa.1 uc007vaa.2 uc007vaa.3 
ENSMUST00000026649.14 Syngr2 ENSMUST00000026649.14 synaptogyrin 2 (from RefSeq NM_009304.2) ENSMUST00000026649.1 ENSMUST00000026649.10 ENSMUST00000026649.11 ENSMUST00000026649.12 ENSMUST00000026649.13 ENSMUST00000026649.2 ENSMUST00000026649.3 ENSMUST00000026649.4 ENSMUST00000026649.5 ENSMUST00000026649.6 ENSMUST00000026649.7 ENSMUST00000026649.8 ENSMUST00000026649.9 NM_009304 O55101 Q3TCK2 Q8C225 Q99K83 SNG2_MOUSE Syngr2 uc007mnx.1 uc007mnx.2 uc007mnx.3 uc007mnx.4 May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. Cytoplasmic vesicle membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Note=Localizes to cytoplasmic vesicles associated with the recycling endosomes. May be tyrosine phosphorylated by Src. Belongs to the synaptogyrin family. protein binding protein targeting synaptic vesicle membrane integral component of membrane cell junction cytoplasmic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle neuromuscular junction regulated exocytosis synapse synaptic vesicle membrane organization uc007mnx.1 uc007mnx.2 uc007mnx.3 uc007mnx.4 
ENSMUST00000026658.13 Tnrc6c ENSMUST00000026658.13 trinucleotide repeat containing 6C, transcript variant 1 (from RefSeq NM_198022.2) B1ATC3 B1ATC3_MOUSE ENSMUST00000026658.1 ENSMUST00000026658.10 ENSMUST00000026658.11 ENSMUST00000026658.12 ENSMUST00000026658.2 ENSMUST00000026658.3 ENSMUST00000026658.4 ENSMUST00000026658.5 ENSMUST00000026658.6 ENSMUST00000026658.7 ENSMUST00000026658.8 ENSMUST00000026658.9 NM_198022 Tnrc6c uc007mni.1 uc007mni.2 uc007mni.3 uc007mni.4 uc007mni.5 Belongs to the GW182 family. nucleic acid binding gene silencing by miRNA miRNA mediated inhibition of translation positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay uc007mni.1 uc007mni.2 uc007mni.3 uc007mni.4 uc007mni.5 
ENSMUST00000026659.10 Tmc6 ENSMUST00000026659.10 transmembrane channel-like gene family 6, transcript variant 1 (from RefSeq NM_145439.3) B1ATB3 B1ATB3_MOUSE ENSMUST00000026659.1 ENSMUST00000026659.2 ENSMUST00000026659.3 ENSMUST00000026659.4 ENSMUST00000026659.5 ENSMUST00000026659.6 ENSMUST00000026659.7 ENSMUST00000026659.8 ENSMUST00000026659.9 NM_145439 Tmc6 uc007mno.1 uc007mno.2 uc007mno.3 uc007mno.4 Membrane ulti-pass membrane protein Belongs to the TMC family. cytoplasm endoplasmic reticulum Golgi apparatus integral component of plasma membrane membrane integral component of membrane nuclear membrane uc007mno.1 uc007mno.2 uc007mno.3 uc007mno.4 
ENSMUST00000026661.4 Tk1 ENSMUST00000026661.4 thymidine kinase 1, transcript variant 1 (from RefSeq NM_009387.2) ENSMUST00000026661.1 ENSMUST00000026661.2 ENSMUST00000026661.3 KITH_MOUSE NM_009387 P04184 Q58EU0 Q8C3P8 Q921J8 Tk-1 uc007mnz.1 uc007mnz.2 uc007mnz.3 uc007mnz.4 Cell-cycle-regulated enzyme of importance in nucleotide metabolism. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration. Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19130; Evidence=; Homotetramer. Tetramerization from dimerization is induced by ATP and increases catalytic efficiency due to a high affinity for thymidine. Tetramerization is inhibited by phosphorylation at Ser-13. Interacts (via the KEN box) with FZR1. Cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P04184-1; Sequence=Displayed; Name=2; IsoId=P04184-2; Sequence=VSP_061491; KEN box sequence located in the C-terminal region is required for its mitotic degradation by the APC/C-FZR1 ubiquitin ligase and interaction capability with FZR1. Phosphorylated on Ser-13 in mitosis. Phosphorylation of Ser-13 by CDK1 during mitosis reduces homotetramerization and catalytic efficiency when DNA replication is complete and intracellular TK1 is still present at a high level. Polyubiquitinated. Postmitosis, ubiquitination leads to proteasomal degradation. The KEN box sequence located at the C-terminal region targets for degradation by the anaphase promoting complex (APC/C) activated and rate-limited by FZR1. Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells. Belongs to the thymidine kinase family. nucleotide binding thymidine kinase activity ATP binding cytoplasm cytosol DNA metabolic process zinc ion binding deoxyribonucleoside monophosphate biosynthetic process kinase activity phosphorylation transferase activity identical protein binding thymidine metabolic process metal ion binding protein homotetramerization DNA biosynthetic process uc007mnz.1 uc007mnz.2 uc007mnz.3 uc007mnz.4 
ENSMUST00000026662.8 Cbx2 ENSMUST00000026662.8 chromobox 2 (from RefSeq NM_007623.3) A2ABG2 CBX2_MOUSE ENSMUST00000026662.1 ENSMUST00000026662.2 ENSMUST00000026662.3 ENSMUST00000026662.4 ENSMUST00000026662.5 ENSMUST00000026662.6 ENSMUST00000026662.7 M33 NM_007623 O35731 P30658 Q8CIA0 uc007mpt.1 uc007mpt.2 uc007mpt.3 uc007mpt.4 This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in results in male-to-female gonadal sex reversal. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035199.1, AK157869.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (By similarity). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (PubMed:16537902). Plays a role in the lineage differentiation of the germ layers in embryonic development (PubMed:22226355). Involved in sexual development, acting as activator of NR5A1 expression (By similarity). Component of a PRC1-like complex (By similarity). The composition of the PRC1 complex may differ between the PRC1 complex in pluripotent embryonic stem cells containing RNF2, CBX7 and PCGF2, and the PRC1 complex in differentiating cells containing RNF2, CBX2, CBX4 and BMI1 (PubMed:22226355). Interacts with RING1/RNF2 (PubMed:9312051, PubMed:22226355). Interacts (via chromodomain) with histone H3K9Me3 and H3K27me3 (PubMed:16537902). May interact with H3C15 and H3C1 (By similarity). P30658; Q60848: Hells; NbExp=2; IntAct=EBI-360174, EBI-3043887; P30658; Q8CCI5: Rybp; NbExp=3; IntAct=EBI-360174, EBI-929290; Nucleus speckle Chromosome Note=Localizes to the inactivated X chromosome in females. Expressed in embryoid bodies. Expressed in most embryonic tissues except the heart from 8.5 to 11.5 dpc. Expressed in central nervous system (CNS, ventricular zone and spinal cord), peripheral nervous system (PNS, sensory cranial and spinal ganglia), olfactory and tongue epithelia, lung, gastrointestinal duct and urogenital system at 13.5 dpc. Expressed in CNS, thymus, various epithelial cell types including the olfactory, tooth and tongue epithelia at 15.5 dpc. negative regulation of transcription from RNA polymerase II promoter euchromatin heterochromatin DNA binding chromatin binding protein binding nucleus nucleoplasm chromosome chromatin organization nuclear speck PcG protein complex methylated histone binding PRC1 complex development of primary sexual characteristics uc007mpt.1 uc007mpt.2 uc007mpt.3 uc007mpt.4 
ENSMUST00000026663.8 Cbx8 ENSMUST00000026663.8 chromobox 8 (from RefSeq NM_013926.1) CBX8_MOUSE ENSMUST00000026663.1 ENSMUST00000026663.2 ENSMUST00000026663.3 ENSMUST00000026663.4 ENSMUST00000026663.5 ENSMUST00000026663.6 ENSMUST00000026663.7 NM_013926 Pc3 Q9QXV1 uc007mpu.1 uc007mpu.2 uc007mpu.3 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Component of a PRC1-like complex (PubMed:16359901). Interacts with RING1, RNF2, PCGF1, PCGF2, PCGF3, BMI1, PCGF5, PCGF6 and PHC2 (PubMed:16359901). Interacts with histone H3 (By similarity). Interacts with MLLT3 (Ref.8). Interacts with PHC2 (By similarity). Interacts (via chromodomain) with single-stranded RNA (PubMed:16537902). Q9QXV1; P25916: Bmi1; NbExp=3; IntAct=EBI-1216641, EBI-927401; Q9QXV1; O35730: Ring1; NbExp=2; IntAct=EBI-1216641, EBI-929310; Q9QXV1; Q9CQJ4: Rnf2; NbExp=5; IntAct=EBI-1216641, EBI-927321; Nucleus Chromosome Note=Localizes to the inactivated X chromosome in females. negative regulation of transcription from RNA polymerase II promoter ubiquitin ligase complex nuclear chromatin heterochromatin single-stranded RNA binding protein binding nucleus nucleoplasm chromosome chromatin organization chromatin silencing positive regulation of cell proliferation histone ubiquitination PcG protein complex positive regulation of collagen biosynthetic process methylated histone binding PRC1 complex positive regulation of DNA repair regulation of catalytic activity cellular response to hydrogen peroxide ubiquitin-protein transferase activator activity uc007mpu.1 uc007mpu.2 uc007mpu.3 
ENSMUST00000026665.8 Cbx4 ENSMUST00000026665.8 chromobox 4 (from RefSeq NM_007625.3) CBX4_MOUSE ENSMUST00000026665.1 ENSMUST00000026665.2 ENSMUST00000026665.3 ENSMUST00000026665.4 ENSMUST00000026665.5 ENSMUST00000026665.6 ENSMUST00000026665.7 NM_007625 O55187 Pc2 Q149G5 Q149G6 uc007mpw.1 uc007mpw.2 uc007mpw.3 uc007mpw.4 E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (By similarity). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (PubMed:16537902). Plays a role in the lineage differentiation of the germ layers in embryonic development (PubMed:22226355). Protein modification; protein sumoylation. Interacts with SUV39H1 and HIPK2 (By similarity). Interacts with CSNK2B (By similarity). Component of a PRC1-like complex (By similarity). The composition of the PRC1 complex differs between the PRC1 complex in pluripotent embryonic stem cells containing RNF2, CBX7 and PCGF2, and the PRC1 complex in differentiating cells containing RNF2, CBX2, CBX4 and BMI1 (PubMed:22226355). Interacts with RNF2 (PubMed:22226355). Interacts (via chromodomain) with histone H3K9Me3 and single-stranded RNA (ssRNA) (PubMed:16537902). Interacts with CHTOP (PubMed:22872859). May interact with H3C15 and H3C1 (By similarity). Interacts with PRDM1 (By similarity). Nucleus Nucleus speckle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O55187-1; Sequence=Displayed; Name=2; IsoId=O55187-2; Sequence=VSP_022009; Expressed in embryoid bodies. The polyhistidine repeat may act as a targeting signal to nuclear speckles. Ubiquitinated. Ubiquitination regulates the function of the Polycomb group (PcG) multiprotein PRC1-like complex. Deubiquitinated by USP26. negative regulation of transcription from RNA polymerase II promoter chromatin binding single-stranded RNA binding protein binding nucleus nucleoplasm chromatin organization nuclear body nuclear speck transferase activity protein sumoylation SUMO transferase activity enzyme binding PcG protein complex SUMO binding methylated histone binding PRC1 complex transcription regulatory region DNA binding negative regulation of transcription, DNA-templated phosphoprotein binding uc007mpw.1 uc007mpw.2 uc007mpw.3 uc007mpw.4 
ENSMUST00000026667.15 Eif4a3 ENSMUST00000026667.15 eukaryotic translation initiation factor 4A3 (from RefSeq NM_138669.1) B2RY38 Ddx48 ENSMUST00000026667.1 ENSMUST00000026667.10 ENSMUST00000026667.11 ENSMUST00000026667.12 ENSMUST00000026667.13 ENSMUST00000026667.14 ENSMUST00000026667.2 ENSMUST00000026667.3 ENSMUST00000026667.4 ENSMUST00000026667.5 ENSMUST00000026667.6 ENSMUST00000026667.7 ENSMUST00000026667.8 ENSMUST00000026667.9 IF4A3_MOUSE NM_138669 Q3TEZ8 Q3UD29 Q8BVY3 Q91VC3 uc007mqj.1 uc007mqj.2 uc007mqj.3 ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; The ATPase activity is increased some 4-fold in the presence of RNA. Identified in the spliceosome C complex. Core component of the mRNA splicing-dependent exon junction complex (EJC); the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A. Interacts with CASC3, MAGOH, NXF1, RBM8A and ALYREF/THOC4. May interact with NOM1. Interacts with POLDIP3. Interacts with CWC22 and PRPF19 in an RNA- independent manner. Direct interaction with CWC22 is mediated by the helicase C-terminal domain. Full interaction with CWC22 occurs only when EIF4A3 is not part of the EJC and prevents EIF4A3 binding to RNA. Identified in a complex composed of the EJC core, UPF3B and UPF2. The EJC core can also interact with UPF3A (in vitro). Interacts with NCBP3 (By similarity). Interacts with NRDE2 (By similarity). Interacts with DHX34; the interaction is RNA-independent (By similarity). Nucleus Nucleus speckle Cytoplasm Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites. Belongs to the DEAD box helicase family. eIF4A subfamily. nucleotide binding nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome nucleic acid binding RNA binding RNA helicase activity mRNA binding helicase activity ATP binding nucleus nucleoplasm spliceosomal complex nucleolus cytoplasm rRNA processing mRNA processing regulation of translation poly(A) binding RNA splicing negative regulation of gene expression nuclear speck hydrolase activity negative regulation of translation dendrite exon-exon junction complex selenocysteine insertion sequence binding RNA stem-loop binding ribonucleoprotein complex binding neuronal cell body translation regulator activity positive regulation of translation positive regulation of transcription from RNA polymerase II promoter positive regulation of mRNA splicing, via spliceosome embryonic cranial skeleton morphogenesis mRNA transport U2-type catalytic step 1 spliceosome catalytic step 2 spliceosome negative regulation of excitatory postsynaptic potential glutamatergic synapse postsynaptic cytosol regulation of translation at postsynapse, modulating synaptic transmission regulation of mRNA binding negative regulation of selenocysteine incorporation negative regulation of selenocysteine insertion sequence binding ribonucleoprotein complex uc007mqj.1 uc007mqj.2 uc007mqj.3 
ENSMUST00000026670.5 Nptx1 ENSMUST00000026670.5 neuronal pentraxin 1 (from RefSeq NM_008730.2) ENSMUST00000026670.1 ENSMUST00000026670.2 ENSMUST00000026670.3 ENSMUST00000026670.4 NM_008730 NPTX1_MOUSE Q62443 uc007mqv.1 uc007mqv.2 uc007mqv.3 May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 calcium ions per subunit. ; Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR). Secreted Cytoplasmic vesicle, secretory vesicle Endoplasmic reticulum Expressed in brain and kidney. cytoplasm mitochondrion plasma membrane mitochondrial transport transport vesicle cytoplasmic vesicle cellular response to potassium ion neuron projection synaptic cleft mitochondrial fragmentation involved in apoptotic process metal ion binding axonogenesis involved in innervation regulation of postsynaptic neurotransmitter receptor activity glutamatergic synapse neurotransmitter receptor localization to postsynaptic specialization membrane uc007mqv.1 uc007mqv.2 uc007mqv.3 
ENSMUST00000026671.13 Rptor ENSMUST00000026671.13 regulatory associated protein of MTOR, complex 1, transcript variant 1 (from RefSeq NM_028898.3) A2ACM0 A2ACM0_MOUSE ENSMUST00000026671.1 ENSMUST00000026671.10 ENSMUST00000026671.11 ENSMUST00000026671.12 ENSMUST00000026671.2 ENSMUST00000026671.3 ENSMUST00000026671.4 ENSMUST00000026671.5 ENSMUST00000026671.6 ENSMUST00000026671.7 ENSMUST00000026671.8 ENSMUST00000026671.9 NM_028898 Rptor uc007mqz.1 uc007mqz.2 uc007mqz.3 uc007mqz.4 This gene encodes a subunit of mammalian target of rapamycin complex 1 (mTORC1), a component of the mTOR signaling pathway, which regulates cell growth in response to nutrient and energy levels. The encoded protein may regulate the assembly, localization, and substrate binding of the mTORC1 complex. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Belongs to the WD repeat RAPTOR family. RNA polymerase III type 1 promoter DNA binding RNA polymerase III type 2 promoter DNA binding RNA polymerase III type 3 promoter DNA binding TFIIIC-class transcription factor binding regulation of cell growth positive regulation of endothelial cell proliferation nucleoplasm cytoplasm lysosome cytosol regulation of cell size cytoplasmic stress granule positive regulation of peptidyl-threonine phosphorylation protein kinase binding protein serine/threonine kinase inhibitor activity protein kinase activator activity positive regulation of cell growth dendrite protein binding, bridging cellular response to nutrient levels TOR signaling TORC1 complex positive regulation of TOR signaling activation of protein kinase activity positive regulation of peptidyl-serine phosphorylation TORC1 signaling regulation of phosphorylation neuronal cell body macromolecular complex binding positive regulation of transcription from RNA polymerase III promoter cellular response to amino acid stimulus cellular response to leucine 14-3-3 protein binding negative regulation of protein serine/threonine kinase activity positive regulation of protein serine/threonine kinase activity positive regulation of G1/S transition of mitotic cell cycle uc007mqz.1 uc007mqz.2 uc007mqz.3 uc007mqz.4 
ENSMUST00000026672.8 Pde8a ENSMUST00000026672.8 phosphodiesterase 8A (from RefSeq NM_008803.3) ENSMUST00000026672.1 ENSMUST00000026672.2 ENSMUST00000026672.3 ENSMUST00000026672.4 ENSMUST00000026672.5 ENSMUST00000026672.6 ENSMUST00000026672.7 NM_008803 O88502 PDE8A_MOUSE Pde8 Q059P6 uc009ibt.1 uc009ibt.2 uc009ibt.3 Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser- 259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF- activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine. Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Inhibited by dipyridimole. Insensitive to selective PDE inhibitor rolipram and to the non-selective inhibitor, IBMX. Kinetic parameters: KM=0.15 uM for cAMP ; Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. Interacts with RAF1. The interaction promotes RAF1 activity. Expressed in multiple tissues, with highest levels in testis, followed by liver, heart, skeletal muscle, and kidney. In the testis, expressed specifically in the seminiferous tubules, in postmitotic pachytene spermatocytes (PubMed:9671792). Low expression, if any, in lung, smooth muscle, pancreas, thyroid, thymus, submaxillary gland, spleen, prostate, epididymus, uterus (PubMed:9671792). Expressed in embryos at 7 dpc. Not detected at later stages, including 11, 15 and 17 dpc (PubMed:9671792). In the testis, expression restricted to middle and late pachytene spermatocytes (PubMed:9671792). Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain. Phosphorylated at Ser-355 by PKA under elevated cAMP conditions, this enhances catalytic activity. Reduced phosphorylation of Mapk1/Erk2 and Mapk3/Erk1, both basal levels and those induced by EGF treatment. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. positive regulation of protein phosphorylation 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cAMP catabolic process signal transduction phosphoric diester hydrolase activity hydrolase activity kinase binding metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity negative regulation of cell death positive regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus negative regulation of hydrogen peroxide-induced cell death uc009ibt.1 uc009ibt.2 uc009ibt.3 
ENSMUST00000026677.4 Nat1 ENSMUST00000026677.4 N-acetyl transferase 1 (from RefSeq NM_008673.2) ENSMUST00000026677.1 ENSMUST00000026677.2 ENSMUST00000026677.3 NM_008673 Nat1 Q546L3 Q546L3_MOUSE uc009lvv.1 uc009lvv.2 uc009lvv.3 Belongs to the arylamine N-acetyltransferase family. liver development arylamine N-acetyltransferase activity cytosol aging N-acetyltransferase activity acetyltransferase activity transferase activity transferase activity, transferring acyl groups response to thyroxine uc009lvv.1 uc009lvv.2 uc009lvv.3 
ENSMUST00000026681.7 Tma16 ENSMUST00000026681.7 translation machinery associated 16, transcript variant 1 (from RefSeq NM_025465.3) ENSMUST00000026681.1 ENSMUST00000026681.2 ENSMUST00000026681.3 ENSMUST00000026681.4 ENSMUST00000026681.5 ENSMUST00000026681.6 NM_025465 Q05DD8 Q9CR02 TMA16_MOUSE uc029wtj.1 uc029wtj.2 uc029wtj.3 Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. Associates with pre-60S ribosomal particles. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CR02-1; Sequence=Displayed; Name=2; IsoId=Q9CR02-2; Sequence=VSP_031803; Belongs to the TMA16 family. molecular_function nucleus nucleolus biological_process uc029wtj.1 uc029wtj.2 uc029wtj.3 
ENSMUST00000026693.14 Zfp202 ENSMUST00000026693.14 zinc finger protein 202, transcript variant 1 (from RefSeq NM_030713.2) ENSMUST00000026693.1 ENSMUST00000026693.10 ENSMUST00000026693.11 ENSMUST00000026693.12 ENSMUST00000026693.13 ENSMUST00000026693.2 ENSMUST00000026693.3 ENSMUST00000026693.4 ENSMUST00000026693.5 ENSMUST00000026693.6 ENSMUST00000026693.7 ENSMUST00000026693.8 ENSMUST00000026693.9 NM_030713 Q8C879 Q8C879_MOUSE Zfp202 uc009ozg.1 uc009ozg.2 uc009ozg.3 uc009ozg.4 Nucleus negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009ozg.1 uc009ozg.2 uc009ozg.3 uc009ozg.4 
ENSMUST00000026698.8 Podxl ENSMUST00000026698.8 podocalyxin-like (from RefSeq NM_013723.3) ENSMUST00000026698.1 ENSMUST00000026698.2 ENSMUST00000026698.3 ENSMUST00000026698.4 ENSMUST00000026698.5 ENSMUST00000026698.6 ENSMUST00000026698.7 NM_013723 PODXL_MOUSE Pclp1 Q9ESZ1 Q9R0M4 uc009bgh.1 uc009bgh.2 uc009bgh.3 uc009bgh.4 Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro- adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin- dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. Monomer; when associated with the membrane raft. Oligomer; when integrated in the apical membrane. Found in a complex with EZR, PODXL and NHERF2. Associates with the actin cytoskeleton through complex formation with EZR and NHERF2. Interacts (via the C-terminal PDZ-binding motif DTHL) with NHERF1 (via the PDZ domains); interaction is not detected in glomerular epithelium cells, take place early in the secretory pathway and is necessary for its apical membrane sorting. Interacts (via the C-terminal PDZ-binding motif DTHL) with NHERF2 (via the PDZ 1 domain); interaction is detected in glomerular epithelium cells. Interacts with EZR (By similarity). Apical cell membrane Cell projection, microvillus Membrane raft Cell projection, lamellipodium Cell projection, filopodium Cell projection, ruffle Membrane ; Single-pass type I membrane protein Note=In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with NHERF2 at the apical plasma membrane during epithelial polarization. Colocalizes with NHERF1 at the trans-Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial cells. Colocalizes with the submembrane actin of lamellipodia, particularly associated with ruffles. Colocalizes with vinculin at protrusions of cells. Colocalizes with ITGB1. Colocalizes with EZR and NHERF2 at the apical cell membrane of glomerular epithelium cells (By similarity). Colocalizes with actin filaments, EZR and NHERF1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, RAB11A and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis (By similarity). Expressed in liver cells and hematopoietic cells (at protein level). Glomerular epithelium cell (podocyte). Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis. The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with NHERF1 and for targeting NHERF1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation (By similarity). N- and O-linked glycosylated. Sialoglycoprotein (By similarity). Die within the first 24 hours of postnatal life from profound defects in kidney and/or gut formation. They are anuric (no measurable urine in the bladder), and fail to generate the extensive interdigitated foot process and instead retain cell junctions between immature podocytes. Belongs to the podocalyxin family. ruffle cytoplasm plasma membrane microvillus cell adhesion negative regulation of cell adhesion membrane integral component of membrane apical plasma membrane cell migration regulation of cell-cell adhesion negative regulation of cell-cell adhesion lamellipodium filopodium positive regulation of cell migration microvillus membrane regulation of microvillus assembly positive regulation of cell-cell adhesion mediated by integrin slit diaphragm cell projection cell body membrane raft leukocyte migration glomerular visceral epithelial cell development epithelial tube formation uc009bgh.1 uc009bgh.2 uc009bgh.3 uc009bgh.4 
ENSMUST00000026699.15 Mkln1 ENSMUST00000026699.15 muskelin 1, intracellular mediator containing kelch motifs (from RefSeq NM_013791.2) ENSMUST00000026699.1 ENSMUST00000026699.10 ENSMUST00000026699.11 ENSMUST00000026699.12 ENSMUST00000026699.13 ENSMUST00000026699.14 ENSMUST00000026699.2 ENSMUST00000026699.3 ENSMUST00000026699.4 ENSMUST00000026699.5 ENSMUST00000026699.6 ENSMUST00000026699.7 ENSMUST00000026699.8 ENSMUST00000026699.9 MKLN1_MOUSE NM_013791 O89050 uc009bgf.1 uc009bgf.2 uc009bgf.3 uc009bgf.4 Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (PubMed:21482357). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (PubMed:9724633, PubMed:18710924). Homodimer; may form higher oligomers (By similarity). Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (By similarity). Interacts with RANBP9 (PubMed:18710924). Part of a complex consisting of RANBP9, MKLN1 and GID8 (By similarity). Interacts with GABRA1 (PubMed:21482357). Interacts with the C-terminal tail of PTGER3 (By similarity). O89050; O89050: Mkln1; NbExp=4; IntAct=EBI-11017656, EBI-11017656; Cytoplasm Cytoplasm, cytosol Nucleus, nucleoplasm Cell projection, ruffle Cytoplasm, cell cortex Synapse Postsynapse Note=Colocalizes with GABRA1 at synapses and in postsynaptic regions (PubMed:21482357). Colocalizes with actin fibers in the cell cortex. Detected in brain, especially in hippocampus and cerebellum (at protein level). The LisH domain contains a nuclear targeting signal (PubMed:18710924). The LisH domain mediates head to tail dimerization (By similarity). No visible phenotype. Hippocampus slices from mutant mice show minor differences in the amplitude of miniature inhibitory postsynaptic currents, and somewhat slower decay times. ubiquitin ligase complex ruffle regulation of receptor internalization protein binding nucleus nucleoplasm cytoplasm cytosol cell cortex cell-matrix adhesion regulation of cell shape cell junction actin cytoskeleton reorganization identical protein binding protein homodimerization activity cell projection synapse uc009bgf.1 uc009bgf.2 uc009bgf.3 uc009bgf.4 
ENSMUST00000026700.8 Map3k7cl ENSMUST00000026700.8 Map3k7 C-terminal like, transcript variant 1 (from RefSeq NM_144854.3) ENSMUST00000026700.1 ENSMUST00000026700.2 ENSMUST00000026700.3 ENSMUST00000026700.4 ENSMUST00000026700.5 ENSMUST00000026700.6 ENSMUST00000026700.7 Map3k7cl NM_144854 ORF63 Q544C0 Q544C0_MOUSE uc012ahq.1 uc012ahq.2 uc012ahq.1 uc012ahq.2 
ENSMUST00000026703.6 Bach1 ENSMUST00000026703.6 BTB and CNC homology 1, basic leucine zipper transcription factor 1 (from RefSeq NM_007520.2) Bach1 ENSMUST00000026703.1 ENSMUST00000026703.2 ENSMUST00000026703.3 ENSMUST00000026703.4 ENSMUST00000026703.5 NM_007520 Q3URL4 Q3URL4_MOUSE uc007zuq.1 uc007zuq.2 uc007zuq.3 regulation of transcription involved in G1/S transition of mitotic cell cycle regulation of transcription involved in G2/M transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus DNA repair regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter in response to hypoxia uc007zuq.1 uc007zuq.2 uc007zuq.3 
ENSMUST00000026704.14 Cct8 ENSMUST00000026704.14 chaperonin containing TCP1 subunit 8 (from RefSeq NM_009840.3) Cct8 ENSMUST00000026704.1 ENSMUST00000026704.10 ENSMUST00000026704.11 ENSMUST00000026704.12 ENSMUST00000026704.13 ENSMUST00000026704.2 ENSMUST00000026704.3 ENSMUST00000026704.4 ENSMUST00000026704.5 ENSMUST00000026704.6 ENSMUST00000026704.7 ENSMUST00000026704.8 ENSMUST00000026704.9 NM_009840 Q3UL22 Q3UL22_MOUSE uc007zul.1 uc007zul.2 uc007zul.3 Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Belongs to the TCP-1 chaperonin family. nucleotide binding ATP binding nucleoplasm cytoplasm centrosome cytosol chaperonin-containing T-complex microtubule protein folding positive regulation of telomere maintenance via telomerase intermediate filament cytoskeleton protein stabilization unfolded protein binding positive regulation of establishment of protein localization to telomere uc007zul.1 uc007zul.2 uc007zul.3 
ENSMUST00000026710.12 Usp16 ENSMUST00000026710.12 ubiquitin specific peptidase 16 (from RefSeq NM_024258.2) ENSMUST00000026710.1 ENSMUST00000026710.10 ENSMUST00000026710.11 ENSMUST00000026710.2 ENSMUST00000026710.3 ENSMUST00000026710.4 ENSMUST00000026710.5 ENSMUST00000026710.6 ENSMUST00000026710.7 ENSMUST00000026710.8 ENSMUST00000026710.9 G5E860 NM_024258 Q99KM0 Q99LG0 UBP16_MOUSE uc007zuk.1 uc007zuk.2 uc007zuk.3 uc007zuk.4 uc007zuk.5 Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Homotetramer. Associates with late pre-40S ribosomes. Nucleus Cytoplasm The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity. Usp16 acts as a regulator of stem cell self-renewal and its overexpression contributes to somatic stem cell defects observed in Down syndrome models in mouse. Usp16 is triplicated in Ts65D Down syndrome mouse model and its overexpression leads to reduce the self- renewal of haematopoietic stem cells and the expansion of mammary epithelial cells, neural progenitors and fibroblasts. Defects are rescued by down-regulating Usp16 in Ts65D mice by short interfering RNAs (PubMed:24025767). Belongs to the peptidase C19 family. USP16 subfamily. mitotic cell cycle transcription coactivator activity cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding nucleus chromatin organization regulation of transcription from RNA polymerase II promoter proteolysis ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus cell cycle peptidase activity cysteine-type peptidase activity zinc ion binding regulation of gene expression histone deubiquitination protein deubiquitination hydrolase activity monoubiquitinated histone H2A deubiquitination thiol-dependent ubiquitinyl hydrolase activity histone binding ubiquitin binding positive regulation of transcription, DNA-templated positive regulation of translational elongation positive regulation of transcription from RNA polymerase II promoter metal ion binding protein homotetramerization cell division regulation of cell cycle histone H2A K63-linked deubiquitination uc007zuk.1 uc007zuk.2 uc007zuk.3 uc007zuk.4 uc007zuk.5 
ENSMUST00000026723.9 Hprt1 ENSMUST00000026723.9 hypoxanthine phosphoribosyltransferase 1 (from RefSeq NM_013556.2) ENSMUST00000026723.1 ENSMUST00000026723.2 ENSMUST00000026723.3 ENSMUST00000026723.4 ENSMUST00000026723.5 ENSMUST00000026723.6 ENSMUST00000026723.7 ENSMUST00000026723.8 HPRT_MOUSE Hprt NM_013556 P00493 Q545Y2 uc009ter.1 uc009ter.2 uc009ter.3 The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146626.1, BC004686.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). Reaction=diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine; Xref=Rhea:RHEA:17973, ChEBI:CHEBI:17368, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58053; EC=2.4.2.8; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17975; Evidence=; Reaction=diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine; Xref=Rhea:RHEA:25424, ChEBI:CHEBI:16235, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58115; EC=2.4.2.8; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:25426; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein. ; Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. Homotetramer. Cytoplasm. Belongs to the purine/pyrimidine phosphoribosyltransferase family. nucleotide binding magnesium ion binding T cell mediated cytotoxicity response to amphetamine hypoxanthine phosphoribosyltransferase activity cytoplasm cytosol purine nucleotide biosynthetic process purine ribonucleoside salvage adenine salvage guanine salvage grooming behavior locomotory behavior nucleoside metabolic process transferase activity transferase activity, transferring glycosyl groups striatum development cerebral cortex neuron differentiation central nervous system neuron development GMP salvage IMP salvage dopamine metabolic process identical protein binding protein homodimerization activity hypoxanthine salvage positive regulation of dopamine metabolic process GMP catabolic process IMP metabolic process adenine metabolic process hypoxanthine metabolic process lymphocyte proliferation metal ion binding dendrite morphogenesis protein homotetramerization guanine phosphoribosyltransferase activity uc009ter.1 uc009ter.2 uc009ter.3 
ENSMUST00000026735.9 Ccdc51 ENSMUST00000026735.9 coiled-coil domain containing 51 (from RefSeq NM_025689.4) Ccdc51 ENSMUST00000026735.1 ENSMUST00000026735.2 ENSMUST00000026735.3 ENSMUST00000026735.4 ENSMUST00000026735.5 ENSMUST00000026735.6 ENSMUST00000026735.7 ENSMUST00000026735.8 MITOK_MOUSE Mitok NM_025689 Q3URS9 Q4QQL1 Q9CXS1 uc009rrx.1 uc009rrx.2 uc009rrx.3 uc009rrx.4 Mitochondrial potassium channel located in the mitochondrial inner membrane (PubMed:31435016). Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria that mediates ATP- dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (PubMed:31435016). May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume (PubMed:31435016). Inhibited by ATP via mitoK(ATP) channel. The mitochondrial potassium channel (mitoK(ATP)) is composed of 4 subunits of CCDC51/MITOK and 4 subunits of ABCB8/MITOSUR. Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3URS9-1; Sequence=Displayed; Name=2; IsoId=Q3URS9-2; Sequence=VSP_025801; Knockout mice exhibit no visible phenotype (PubMed:31435016). Mutant mice are slightly more sensitive to the ischaemia-reperfusion protocol (PubMed:31435016). molecular_function mitochondrion biological_process membrane integral component of membrane uc009rrx.1 uc009rrx.2 uc009rrx.3 uc009rrx.4 
ENSMUST00000026743.14 Uqcrc1 ENSMUST00000026743.14 ubiquinol-cytochrome c reductase core protein 1 (from RefSeq NM_025407.2) ENSMUST00000026743.1 ENSMUST00000026743.10 ENSMUST00000026743.11 ENSMUST00000026743.12 ENSMUST00000026743.13 ENSMUST00000026743.2 ENSMUST00000026743.3 ENSMUST00000026743.4 ENSMUST00000026743.5 ENSMUST00000026743.6 ENSMUST00000026743.7 ENSMUST00000026743.8 ENSMUST00000026743.9 NM_025407 Q3TV75 Q9CWL6 Q9CZ13 QCR1_MOUSE uc009rrg.1 uc009rrg.2 uc009rrg.3 Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (By similarity). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (By similarity). Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:19026783). Interacts with UQCC6 (PubMed:32161263). Interacts with STMP1 (PubMed:35101990). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Expressed in neurons and astrocytes of the cerebral cortex and hippocampus (at protein level). Acetylation of Lys-138 is observed in liver mitochondria from fasted mice but not from fed mice. Results in early embryonic lethality. Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily. catalytic activity protein binding mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex III cytosol mitochondrial electron transport, ubiquinol to cytochrome c response to activity membrane ubiquitin protein ligase binding myelin sheath response to alkaloid macromolecular complex binding metal ion binding oxidation-reduction process respiratory chain uc009rrg.1 uc009rrg.2 uc009rrg.3 
ENSMUST00000026744.6 Tmem89 ENSMUST00000026744.6 transmembrane protein 89 (from RefSeq NM_027066.1) ENSMUST00000026744.1 ENSMUST00000026744.2 ENSMUST00000026744.3 ENSMUST00000026744.4 ENSMUST00000026744.5 NM_027066 Q2M2L9 Q9DA04 TMM89_MOUSE uc009rrf.1 uc009rrf.2 Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DA04-1; Sequence=Displayed; Name=2; IsoId=Q9DA04-2; Sequence=VSP_026116, VSP_026117; Sequence=BAB24511.1; Type=Frameshift; Evidence=; molecular_function biological_process membrane integral component of membrane uc009rrf.1 uc009rrf.2 
ENSMUST00000026750.15 Cnksr2 ENSMUST00000026750.15 connector enhancer of kinase suppressor of Ras 2, transcript variant 1 (from RefSeq NM_177751.3) CNKR2_MOUSE ENSMUST00000026750.1 ENSMUST00000026750.10 ENSMUST00000026750.11 ENSMUST00000026750.12 ENSMUST00000026750.13 ENSMUST00000026750.14 ENSMUST00000026750.2 ENSMUST00000026750.3 ENSMUST00000026750.4 ENSMUST00000026750.5 ENSMUST00000026750.6 ENSMUST00000026750.7 ENSMUST00000026750.8 ENSMUST00000026750.9 Kiaa0902 NM_177751 Q80TP2 Q80YA9 uc009ush.1 uc009ush.2 uc009ush.3 uc009ush.4 May function as an adapter protein or regulator of Ras signaling pathways. Interacts with RAF1, RAB2L and RAL GTPase proteins. Q80YA9; Q9D415: Dlgap1; NbExp=3; IntAct=EBI-771429, EBI-400152; Cytoplasm Membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80YA9-1; Sequence=Displayed; Name=2; IsoId=Q80YA9-2; Sequence=VSP_010890; Phosphorylated on tyrosine. Belongs to the CNKSR family. Sequence=BAC65681.1; Type=Erroneous initiation; Evidence=; protein binding cytoplasm plasma membrane regulation of signal transduction postsynaptic density membrane protein kinase binding intracellular signal transduction identical protein binding neuron projection neuronal cell body postsynaptic membrane glutamatergic synapse uc009ush.1 uc009ush.2 uc009ush.3 uc009ush.4 
ENSMUST00000026760.3 Tmem47 ENSMUST00000026760.3 transmembrane protein 47 (from RefSeq NM_138751.2) B1AUN5 ENSMUST00000026760.1 ENSMUST00000026760.2 MNCb-0941 NM_138751 Q3TS34 Q3UZL4 Q8C0H5 Q9JJG6 TMM47_MOUSE Tm4sf10 uc009tre.1 uc009tre.2 uc009tre.3 uc009tre.4 Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B (PubMed:26990309). During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (PubMed:21881001). Interacts with CTNNB1, CTNNA1, PRKCI, PARD6B (By similarity). Interacts with FYB1. Q9JJG6; O35601: Fyb1; NbExp=4; IntAct=EBI-11685657, EBI-7353747; Membrane ; Multi-pass membrane protein Cell junction ll junction, adherens junction Note=In undifferentiated cultured podocytes localizes to the perinuclear region and translocates to the cell membrane after Cadherin appearance at cell-cell contacts. Upon differentiation of cultured podocytes, protein disappears from cell contacts and expression ceases. Re-expressed upon induced podocyte injury. Colocalizes with FYB1 at cell-cell contacts in podocytes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JJG6-1; Sequence=Displayed; Name=2; IsoId=Q9JJG6-2; Sequence=VSP_034861; Expressed in podocytes (at protein level). Expression in kidney peaks at postnatal day 4 and declines to undetectable levels by day 15. In adults very low expression detected in the basal region of lateral membranes of few tubule segments (at protein level). Belongs to the TMEM47 family. Sequence=BAE21843.1; Type=Frameshift; Evidence=; protein binding plasma membrane cell-cell junction adherens junction membrane integral component of membrane cell junction uc009tre.1 uc009tre.2 uc009tre.3 uc009tre.4 
ENSMUST00000026795.13 Alox5 ENSMUST00000026795.13 arachidonate 5-lipoxygenase (from RefSeq NM_009662.2) Alox5 ENSMUST00000026795.1 ENSMUST00000026795.10 ENSMUST00000026795.11 ENSMUST00000026795.12 ENSMUST00000026795.2 ENSMUST00000026795.3 ENSMUST00000026795.4 ENSMUST00000026795.5 ENSMUST00000026795.6 ENSMUST00000026795.7 ENSMUST00000026795.8 ENSMUST00000026795.9 LOX5_MOUSE NM_009662 P48999 Q3TB75 uc009dkd.1 uc009dkd.2 uc009dkd.3 Catalyzes the oxygenation of arachidonate to 5- hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation (PubMed:7629107, PubMed:7809134, PubMed:7969451, PubMed:23246375, PubMed:31642348). Also catalyzes the oxygenation of arachidonic acid into 8-hydroperoxyicosatetraenoic acid (8-HPETE) and 12-hydroperoxyicosatetraenoic acid (12-HPETE) (PubMed:23246375). Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene (By similarity). Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses (PubMed:31642348). Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma)(PubMed:21307302). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers (PubMed:31642348). In addition to inflammatory processes, participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (PubMed:24226420, PubMed:23720274, PubMed:17392829, PubMed:28965882). Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 (PubMed:21224059). May also play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (PubMed:28694473, PubMed:18421434). Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (PubMed:24906289). Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy- (6E,8Z,11Z,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:17485, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57450; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17486; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4; Xref=Rhea:RHEA:32307, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57463; EC=1.13.11.34; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32308; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8S)-hydroperoxy- (5Z,9E,11Z,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:38675, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:75322; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38676; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy- (5Z,8Z,10E,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:10428, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57444; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10429; Evidence=; Reaction=18-HEPE + O2 = (5S)-hydroperoxy-18-hydroxy- (7E,9E,11Z,14Z,16E)-eicosapentaenoate; Xref=Rhea:RHEA:48860, ChEBI:CHEBI:15379, ChEBI:CHEBI:90825, ChEBI:CHEBI:90826; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48861; Evidence=; Reaction=(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate; Xref=Rhea:RHEA:51968, ChEBI:CHEBI:15379, ChEBI:CHEBI:90818, ChEBI:CHEBI:132218; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51969; Evidence=; Reaction=(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate; Xref=Rhea:RHEA:50204, ChEBI:CHEBI:15379, ChEBI:CHEBI:132083, ChEBI:CHEBI:132091; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50205; Evidence=; Reaction=(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)- eicosapentaenoate = (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate + H2O; Xref=Rhea:RHEA:39107, ChEBI:CHEBI:15377, ChEBI:CHEBI:132091, ChEBI:CHEBI:134661; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39108; Evidence=; Reaction=(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)- eicosapentaenoate = (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate + H2O; Xref=Rhea:RHEA:50268, ChEBI:CHEBI:15377, ChEBI:CHEBI:132218, ChEBI:CHEBI:132219; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50269; Evidence=; Reaction=(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate = (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate + H2O; Xref=Rhea:RHEA:50844, ChEBI:CHEBI:15377, ChEBI:CHEBI:90826, ChEBI:CHEBI:133812; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50845; Evidence=; Reaction=(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)- hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:48624, ChEBI:CHEBI:15379, ChEBI:CHEBI:57409, ChEBI:CHEBI:131564; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48625; Evidence=; Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = H2O + leukotriene A4; Xref=Rhea:RHEA:17961, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:57463; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17962; Evidence=; Reaction=(5Z,8Z)-eicosadienoate + O2 = (5S)-hydroperoxy-(6E,8Z)- eicosadienoate; Xref=Rhea:RHEA:62644, ChEBI:CHEBI:15379, ChEBI:CHEBI:145835, ChEBI:CHEBI:145836; Evidence=; Reaction=(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 = (5S)- hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:62648, ChEBI:CHEBI:15379, ChEBI:CHEBI:90680, ChEBI:CHEBI:145837; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 5-hydroperoxy- (6E,8Z,11Z,14Z,17Z)-eicosapentaenoate; Xref=Rhea:RHEA:62600, ChEBI:CHEBI:15379, ChEBI:CHEBI:58562, ChEBI:CHEBI:145815; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62601; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)- hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate; Xref=Rhea:RHEA:41332, ChEBI:CHEBI:15379, ChEBI:CHEBI:77016, ChEBI:CHEBI:78048; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41333; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S)- hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate; Xref=Rhea:RHEA:64668, ChEBI:CHEBI:15379, ChEBI:CHEBI:77016, ChEBI:CHEBI:156049; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64669; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)- hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate; Xref=Rhea:RHEA:50840, ChEBI:CHEBI:15379, ChEBI:CHEBI:77016, ChEBI:CHEBI:133795; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50841; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence= Note=Binds 1 Fe cation per subunit. Kinetic parameters: KM=44.7 uM for arachidonic acid ; Lipid metabolism; leukotriene A4 biosynthesis. Homodimer. Interacts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and efficient catalytic activity. Interacts with PIK3R1; this interaction bridges ALOX5 with CD40 after CD40 ligation in B cells and leads to the production of reactive oxygen species (ROS). Interacts (via PLAT domain) with DICER1 (via Dicer dsRNA-binding fold domain); this interaction enhances arachidonate 5-lipoxygenase activity and modifies the miRNA precursor processing activity of DICER1. Cytoplasm Nucleus matrix Nucleus membrane ; Peripheral membrane protein Cytoplasm, perinuclear region Cytoplasm, cytosol Nucleus envelope Nucleus intermembrane space Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser- 272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association. Expressed in skin Langerhans cells and their emigrated counterparts in draining lymph nodes (PubMed:17392829). Highly expressed in circulating leukocytes (PubMed:21307302). IncreaseD by both NF-kappa-B and SP1 in LPS-treated monocytes. Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-524 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus. Phosphorylation at Ser-524 is stimulated by 8-bromo-3',5'-cyclic AMP or prostaglandin E2. Homozygous mice for ALOX5 are also present in the expected ratios. Mice are indistinguishable in growth and size from wild type littermates (PubMed:7809134). Homozygous mice for ALOX5 show no apparent abnormalities up to ten months of age under normal physiological conditions, except that the spleen is usually smaller for 8-week-old mice (PubMed:7969451). Can be converted from pro-inflammatory 5-lipoxygenase to anti-inflammatory 15-lipoxygenase by reducing the volume of the substrate-binding pocket. Belongs to the lipoxygenase family. acute inflammatory response leukotriene production involved in inflammatory response arachidonate 5-lipoxygenase activity iron ion binding protein binding nucleus nuclear envelope nuclear envelope lumen nucleoplasm cytoplasm cytosol leukotriene metabolic process inflammatory response membrane nuclear matrix oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen sensory perception of pain leukotriene biosynthetic process dendrite nuclear membrane sarcolemma positive regulation of vasoconstriction metal ion binding dioxygenase activity oxidation-reduction process positive regulation of cytochrome-c oxidase activity uc009dkd.1 uc009dkd.2 uc009dkd.3 
ENSMUST00000026816.15 Wdr73 ENSMUST00000026816.15 WD repeat domain 73, transcript variant 3 (from RefSeq NR_152101.1) ENSMUST00000026816.1 ENSMUST00000026816.10 ENSMUST00000026816.11 ENSMUST00000026816.12 ENSMUST00000026816.13 ENSMUST00000026816.14 ENSMUST00000026816.2 ENSMUST00000026816.3 ENSMUST00000026816.4 ENSMUST00000026816.5 ENSMUST00000026816.6 ENSMUST00000026816.7 ENSMUST00000026816.8 ENSMUST00000026816.9 NR_152101 Q05C70 Q3TEN7 Q571I2 Q8BSB9 Q8CF62 Q9CWR1 WDR73_MOUSE uc009ibl.1 uc009ibl.2 uc009ibl.3 May play a role in the regulation of microtubule organization and dynamics. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Cleavage furrow Note=During interphase, located in the cytosol. During mitosis, accumulates at the spindle poles and microtubule asters and later in the cleavage furrow. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9CWR1-1; Sequence=Displayed; Name=2; IsoId=Q9CWR1-2; Sequence=VSP_028668; Name=3; IsoId=Q9CWR1-3; Sequence=VSP_028669, VSP_028670; Name=4; IsoId=Q9CWR1-4; Sequence=VSP_028667, VSP_028669; Belongs to the WD repeat WDR73 family. Sequence=AAH28870.1; Type=Frameshift; Evidence=; Sequence=BAD90132.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; spindle pole molecular_function cytoplasm spindle cytosol cytoskeleton nucleus organization cytoplasmic microtubule organization cleavage furrow negative regulation of apoptotic process uc009ibl.1 uc009ibl.2 uc009ibl.3 
ENSMUST00000026817.11 Nmb ENSMUST00000026817.11 neuromedin B, transcript variant 2 (from RefSeq NM_026523.4) ENSMUST00000026817.1 ENSMUST00000026817.10 ENSMUST00000026817.2 ENSMUST00000026817.3 ENSMUST00000026817.4 ENSMUST00000026817.5 ENSMUST00000026817.6 ENSMUST00000026817.7 ENSMUST00000026817.8 ENSMUST00000026817.9 NMB_MOUSE NM_026523 Q9CR53 uc009ibm.1 uc009ibm.2 uc009ibm.3 uc009ibm.4 uc009ibm.5 This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in satiety, reproduction and thermoregulation, as well as in stress, fear and other behavioral responses. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2016]. Stimulates smooth muscle contraction (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (PubMed:34133943). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneeze reflex (PubMed:34133943). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (PubMed:30734045). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (PubMed:28780306). Secreted Cell projection, neuron projection Note=In neurons of the retrotrapezoid nucleus//parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex. In the hindbrain, expressed in the medulla surrounding the lateral half of the facial nucleus (PubMed:26855425). Also expressed in the olfactory bulb and hippocampus (PubMed:26855425). Detected in a subset of neurons distributed throughout the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG) (PubMed:26855425). Within the RTN/pFRG, expressed in neuronal subpopulations distinct from those expressing Grp (PubMed:26855425). Expressed in lung (PubMed:31601264). During osteoclast development, expression increases as the cells differentiate with high expression levels in mature osteoclasts (at protein level). Up-regulated in lung tissue in response to infection with influenza A virus. Significant reduction in the sneezing response to capsaicin at both low and high doses but does not affect pain-related nose wiping behavior or apnea induced by capsaicin (PubMed:34133943). Abolishes the sneezing response to histamine, seratonin and the neuropeptide Npff (PubMed:34133943). Abolishes sneezing response to mast cell-dependent allergy (PubMed:34133943). Belongs to the bombesin/neuromedin-B/ranatensin family. extracellular region positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway positive regulation of cell proliferation neuromedin B receptor binding glucose homeostasis neuron projection positive regulation of hormone secretion negative regulation of hormone secretion arachidonic acid secretion uc009ibm.1 uc009ibm.2 uc009ibm.3 uc009ibm.4 uc009ibm.5 
ENSMUST00000026818.12 Sec11a ENSMUST00000026818.12 SEC11 homolog A, signal peptidase complex subunit, transcript variant 1 (from RefSeq NM_019951.2) ENSMUST00000026818.1 ENSMUST00000026818.10 ENSMUST00000026818.11 ENSMUST00000026818.2 ENSMUST00000026818.3 ENSMUST00000026818.4 ENSMUST00000026818.5 ENSMUST00000026818.6 ENSMUST00000026818.7 ENSMUST00000026818.8 ENSMUST00000026818.9 NM_019951 Q9R0P6 SC11A_MOUSE Sec11l1 Sid2895 Spc18 uc009ibn.1 uc009ibn.2 uc009ibn.3 Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids. Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.; EC=3.4.21.89; Evidence=; Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3. Within the complex, interacts with SPCS2 and SPCS3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. Endoplasmic reticulum membrane ; Single-pass type II membrane protein The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates. Belongs to the peptidase S26B family. endoplasmic reticulum signal peptidase complex endoplasmic reticulum membrane signal peptide processing proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity organelle membrane intracellular membrane-bounded organelle uc009ibn.1 uc009ibn.2 uc009ibn.3 
ENSMUST00000026820.11 Slc28a1 ENSMUST00000026820.11 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (from RefSeq NM_001004184.3) E9PXX9 ENSMUST00000026820.1 ENSMUST00000026820.10 ENSMUST00000026820.2 ENSMUST00000026820.3 ENSMUST00000026820.4 ENSMUST00000026820.5 ENSMUST00000026820.6 ENSMUST00000026820.7 ENSMUST00000026820.8 ENSMUST00000026820.9 NM_001004184 Q6P8I9 S28A1_MOUSE Slc28a1 uc009ibs.1 uc009ibs.2 Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient. Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity. Therefore, exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit). Involved in renal nucleoside (re)absorption. Reaction=Na(+)(out) + uridine(out) = Na(+)(in) + uridine(in); Xref=Rhea:RHEA:69887, ChEBI:CHEBI:16704, ChEBI:CHEBI:29101; Evidence=; Reaction=Na(+)(out) + thymidine(out) = Na(+)(in) + thymidine(in); Xref=Rhea:RHEA:69891, ChEBI:CHEBI:17748, ChEBI:CHEBI:29101; Evidence=; Reaction=cytidine(out) + Na(+)(out) = cytidine(in) + Na(+)(in); Xref=Rhea:RHEA:69895, ChEBI:CHEBI:17562, ChEBI:CHEBI:29101; Evidence=; Reaction=adenosine(out) + Na(+)(out) = adenosine(in) + Na(+)(in); Xref=Rhea:RHEA:69927, ChEBI:CHEBI:16335, ChEBI:CHEBI:29101; Evidence=; Due to its high apparent affinity but slow transport, adenosine could act as a negative regulator of pyrimidine transport under some conditions. Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein N-glycosylated. N-glycosylation is required for localization to the plasma membrane and the transporter activity. Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. nucleoside transmembrane transporter activity pyrimidine nucleobase transmembrane transporter activity nucleoside:sodium symporter activity integral component of plasma membrane pyrimidine- and adenine-specific:sodium symporter activity pyrimidine nucleobase transport membrane integral component of membrane apical plasma membrane pyrimidine-containing compound transmembrane transport nucleoside transmembrane transport purine nucleobase transmembrane transport uc009ibs.1 uc009ibs.2 
ENSMUST00000026826.14 Rab40c ENSMUST00000026826.14 Rab40C, member RAS oncogene family (from RefSeq NM_139154.2) ENSMUST00000026826.1 ENSMUST00000026826.10 ENSMUST00000026826.11 ENSMUST00000026826.12 ENSMUST00000026826.13 ENSMUST00000026826.2 ENSMUST00000026826.3 ENSMUST00000026826.4 ENSMUST00000026826.5 ENSMUST00000026826.6 ENSMUST00000026826.7 ENSMUST00000026826.8 ENSMUST00000026826.9 NM_139154 Q8VHQ4 RB40C_MOUSE uc008bco.1 uc008bco.2 uc008bco.3 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Component of the probable SCF-like ECS(RAB40C) E3 ubiquitin- protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and RAB40C. Interacts with CUL5, RNF7, ELOB and ELOC (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity GTP binding endosome plasma membrane intracellular protein transport synaptic vesicle membrane protein ubiquitination GDP binding Rab protein signal transduction intracellular signal transduction perinuclear region of cytoplasm protein localization to plasma membrane uc008bco.1 uc008bco.2 uc008bco.3 
ENSMUST00000026827.16 Mettl26 ENSMUST00000026827.16 methyltransferase like 26 (from RefSeq NM_026686.2) ENSMUST00000026827.1 ENSMUST00000026827.10 ENSMUST00000026827.11 ENSMUST00000026827.12 ENSMUST00000026827.13 ENSMUST00000026827.14 ENSMUST00000026827.15 ENSMUST00000026827.2 ENSMUST00000026827.3 ENSMUST00000026827.4 ENSMUST00000026827.5 ENSMUST00000026827.6 ENSMUST00000026827.7 ENSMUST00000026827.8 ENSMUST00000026827.9 MTL26_MOUSE Mettl26 NM_026686 Q9DCS2 uc008bcl.1 uc008bcl.2 uc008bcl.3 uc008bcl.4 uc008bcl.5 Belongs to the UPF0585 family. molecular_function cellular_component biological_process uc008bcl.1 uc008bcl.2 uc008bcl.3 uc008bcl.4 uc008bcl.5 
ENSMUST00000026828.7 Mcrip2 ENSMUST00000026828.7 MAPK regulated corepressor interacting protein 2, transcript variant 6 (from RefSeq NR_166094.1) ENSMUST00000026828.1 ENSMUST00000026828.2 ENSMUST00000026828.3 ENSMUST00000026828.4 ENSMUST00000026828.5 ENSMUST00000026828.6 Fam195a MCRI2_MOUSE NR_166094 Q9CQB2 uc008bck.1 uc008bck.2 uc008bck.3 Interacts with DDX6. Interacts with MCRIP1. Cytoplasm, Stress granule Nucleus Note=Upon cellular stress, relocalizes to stress granules. Belongs to the MCRIP family. protein binding nucleus cytoplasm biological_process cytoplasmic stress granule uc008bck.1 uc008bck.2 uc008bck.3 
ENSMUST00000026831.14 Rhbdl1 ENSMUST00000026831.14 rhomboid like 1 (from RefSeq NM_144816.1) ENSMUST00000026831.1 ENSMUST00000026831.10 ENSMUST00000026831.11 ENSMUST00000026831.12 ENSMUST00000026831.13 ENSMUST00000026831.2 ENSMUST00000026831.3 ENSMUST00000026831.4 ENSMUST00000026831.5 ENSMUST00000026831.6 ENSMUST00000026831.7 ENSMUST00000026831.8 ENSMUST00000026831.9 NM_144816 Q8VC82 RHBL1_MOUSE Rhbdl uc008bcg.1 uc008bcg.2 uc008bcg.3 May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; Membrane ; Multi-pass membrane protein Belongs to the peptidase S54 family. serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc008bcg.1 uc008bcg.2 uc008bcg.3 
ENSMUST00000026833.6 Wdr24 ENSMUST00000026833.6 WD repeat domain 24 (from RefSeq NM_173741.3) ENSMUST00000026833.1 ENSMUST00000026833.2 ENSMUST00000026833.3 ENSMUST00000026833.4 ENSMUST00000026833.5 NM_173741 Q8CFJ9 WDR24_MOUSE Wdr24 uc008bcd.1 uc008bcd.2 uc008bcd.3 Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (By similarity). GATOR2 probably acts as an E3 ubiquitin- protein ligase toward GATOR1 (By similarity). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (By similarity). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (By similarity). In addition to its role in regulation of the mTORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (By similarity). Within the GATOR2 complex, WDR24 constitutes the catalytic subunit that mediates 'Lys-6'-linked ubiquitination of NPRL2 (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids. In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated. Protein modification; protein ubiquitination. Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids. SESN1, SESN2 and SESN3 convey leucine availability via direct interaction with SEH1L and WDR24. Lysosome membrane Phosphorylation at Ser-155 by AMPK in response to glucose deprivation inactivates WDR24 by promoting interaction with 14-3-3 proteins, such as YWHAG, preventing assembly of the GATOR2 complex. Autoubiquitinated; MIOS is required to prevent autoubiquitination. Belongs to the WD repeat WDR24 family. molecular_function lysosome lysosomal membrane autophagy regulation of autophagy membrane positive regulation of TOR signaling cellular response to amino acid starvation GATOR2 complex uc008bcd.1 uc008bcd.2 uc008bcd.3 
ENSMUST00000026839.5 Prps2 ENSMUST00000026839.5 phosphoribosyl pyrophosphate synthetase 2, transcript variant 2 (from RefSeq NM_026662.5) ENSMUST00000026839.1 ENSMUST00000026839.2 ENSMUST00000026839.3 ENSMUST00000026839.4 NM_026662 PRPS2_MOUSE Q9CS42 Q9CZA9 uc009uxd.1 uc009uxd.2 uc009uxd.3 uc009uxd.4 Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Reaction=ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1- diphosphate + AMP + H(+); Xref=Rhea:RHEA:15609, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58017, ChEBI:CHEBI:78346, ChEBI:CHEBI:456215; EC=2.7.6.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by magnesium and inorganic phosphate. Competitively or non-competitively inhibited by ADP, 2,3- bisphosphoglyceride or GDP (By similarity). Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity). Belongs to the ribose-phosphate pyrophosphokinase family. nucleotide binding magnesium ion binding ribose phosphate diphosphokinase complex ribose phosphate diphosphokinase activity ATP binding cytoplasm 5-phosphoribose 1-diphosphate biosynthetic process purine nucleotide biosynthetic process AMP biosynthetic process nucleoside metabolic process ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process AMP binding kinase activity phosphorylation transferase activity GDP binding ribose phosphate metabolic process carbohydrate binding animal organ regeneration macromolecular complex identical protein binding protein homodimerization activity ADP binding cellular biosynthetic process metal ion binding uc009uxd.1 uc009uxd.2 uc009uxd.3 uc009uxd.4 
ENSMUST00000026841.15 Hadhb ENSMUST00000026841.15 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta, transcript variant 3 (from RefSeq NM_145558.2) ECHB_MOUSE ENSMUST00000026841.1 ENSMUST00000026841.10 ENSMUST00000026841.11 ENSMUST00000026841.12 ENSMUST00000026841.13 ENSMUST00000026841.14 ENSMUST00000026841.2 ENSMUST00000026841.3 ENSMUST00000026841.4 ENSMUST00000026841.5 ENSMUST00000026841.6 ENSMUST00000026841.7 ENSMUST00000026841.8 ENSMUST00000026841.9 NM_145558 Q3TEH9 Q8BJI5 Q8BJM0 Q8BK52 Q99JY0 uc008wvf.1 uc008wvf.2 uc008wvf.3 uc008wvf.4 Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity. Reaction=acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA; Xref=Rhea:RHEA:21564, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58342, ChEBI:CHEBI:90726; EC=2.3.1.16; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21566; Evidence=; Reaction=acetyl-CoA + butanoyl-CoA = 3-oxohexanoyl-CoA + CoA; Xref=Rhea:RHEA:31111, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57371, ChEBI:CHEBI:62418; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31113; Evidence=; Reaction=acetyl-CoA + hexanoyl-CoA = 3-oxooctanoyl-CoA + CoA; Xref=Rhea:RHEA:31203, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:62619, ChEBI:CHEBI:62620; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31205; Evidence=; Reaction=acetyl-CoA + octanoyl-CoA = 3-oxodecanoyl-CoA + CoA; Xref=Rhea:RHEA:31087, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57386, ChEBI:CHEBI:62548; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31089; Evidence=; Reaction=acetyl-CoA + decanoyl-CoA = 3-oxododecanoyl-CoA + CoA; Xref=Rhea:RHEA:31183, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61430, ChEBI:CHEBI:62615; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31185; Evidence=; Reaction=acetyl-CoA + dodecanoyl-CoA = 3-oxotetradecanoyl-CoA + CoA; Xref=Rhea:RHEA:31091, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57375, ChEBI:CHEBI:62543; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31093; Evidence=; Reaction=acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA; Xref=Rhea:RHEA:18161, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57349, ChEBI:CHEBI:57385; EC=2.3.1.155; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18163; Evidence=; Lipid metabolism; fatty acid beta-oxidation. Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme (By similarity). Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear (By similarity). The mitochondrial trifunctional enzyme interacts with MTLN (PubMed:29949755). Interacts with RSAD2/viperin (By similarity). Mitochondrion Mitochondrion inner membrane Mitochondrion outer membrane Endoplasmic reticulum Note=Protein stability and association with membranes require HADHA. Acetylation of Lys-202 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the thiolase-like superfamily. Thiolase family. fatty-acyl-CoA binding catalytic activity 3-hydroxyacyl-CoA dehydrogenase activity acetyl-CoA C-acyltransferase activity enoyl-CoA hydratase activity mitochondrion mitochondrial outer membrane mitochondrial inner membrane endoplasmic reticulum lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation membrane mitochondrial fatty acid beta-oxidation multienzyme complex long-chain-enoyl-CoA hydratase activity long-chain-3-hydroxyacyl-CoA dehydrogenase activity transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups mitochondrial nucleoid macromolecular complex binding acetyl-CoA C-myristoyltransferase activity NAD binding uc008wvf.1 uc008wvf.2 uc008wvf.3 uc008wvf.4 
ENSMUST00000026845.12 Il6 ENSMUST00000026845.12 interleukin 6, transcript variant 1 (from RefSeq NM_031168.2) ENSMUST00000026845.1 ENSMUST00000026845.10 ENSMUST00000026845.11 ENSMUST00000026845.2 ENSMUST00000026845.3 ENSMUST00000026845.4 ENSMUST00000026845.5 ENSMUST00000026845.6 ENSMUST00000026845.7 ENSMUST00000026845.8 ENSMUST00000026845.9 IL6_MOUSE Il-6 Il6 NM_031168 P08505 Q3UCQ0 Q8BN26 uc008wuu.1 uc008wuu.2 uc008wuu.3 This gene encodes a member of the interleukin family of cytokines that have important functions in immune response, hematopoiesis, inflammation and the acute phase response. The ectopic overexpression of the encoded protein in mice results in excessive plasma cells in circulation, leading to death. Mice lacking the encoded protein exhibit abnormalities in hepatic acute phase response, some immune mechanisms, bone resorption in response to estrogen, liver regeneration and wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism (Probable). Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (PubMed:8910279). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (PubMed:27893700). IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury. In the adaptive immune response, is required for the differentiation of B-cells into immunoglolin-secreting cells (Probable). Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Together with IL21, controls the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (PubMed:23045607). Required to drive naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (PubMed:16990136, PubMed:27893700). Also required for proliferation of myeloma cells and the survival of plasmablast cells (Probable). Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF (PubMed:17075861). Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (PubMed:11786910). 'Trans- signaling' in central nervous system regulates energy and glucose homeostasis (PubMed:28402851). Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (PubMed:11113088). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (PubMed:11113088, PubMed:8910279). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (PubMed:15124018). Through activation of IL6ST-YAP- NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity). Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST (PubMed:28265003). Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling (PubMed:28265003). Secreted Expressed by dendritic cells and macrophages (PubMed:27893700, PubMed:23045607). Expressed by activated follicular B cells (PubMed:23045607). Abundantly expressed in the central nervous system (CNS), particularly the hypothalamic region (PubMed:28402851). In activated follicular B cells, expression is induced early after influenza virus infection (PubMed:23045607). Plasma levels are highly increased upon exercise, due to enhanced production by contracting skeletal muscles (PubMed:22037645). N- and O-glycosylated. Animals have normal T-cell numbers in the lamina propria but the T(H)17 cells are reduced by about 10-fold (PubMed:16990136). They develop mature-onset obesity and have disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to leptin treatment (PubMed:11786910). Animals have impaired liver regeneration characterized by liver necrosis and failure (PubMed:8910279). Mutants infected with influenza virus do not show a significant difference on germinal center B cells compared to wild-types (PubMed:23045607). Double knockouts for IL21 and IL6 infected with influenza virus show a significant reduction in germinal centers in both the draining lymphatic nodes and the spleens to wild- types. Animals show a significant reduction in virus-specific IgM and IgG (PubMed:23045607). Belongs to the IL-6 superfamily. neutrophil apoptotic process response to yeast myeloid cell homeostasis hepatic immune response acute inflammatory response positive regulation of acute inflammatory response receptor binding cytokine activity interleukin-6 receptor binding protein binding extracellular region extracellular space cytoplasm interleukin-6 receptor complex negative regulation of protein kinase activity acute-phase response inflammatory response immune response aging growth factor activity positive regulation of cell proliferation negative regulation of cell proliferation regulation of cell shape response to heat response to cold response to wounding response to mechanical stimulus response to bacterium external side of plasma membrane regulation of vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of neuron projection development response to auditory stimulus positive regulation of gliogenesis response to organic cyclic compound cytokine-mediated signaling pathway response to caffeine endocrine pancreas development neuron projection development lymphocyte costimulation response to nutrient levels cellular response to nutrient levels response to lipopolysaccharide positive regulation of chemokine production positive regulation of interleukin-6 production response to insulin negative regulation of collagen biosynthetic process positive regulation of peptidyl-serine phosphorylation response to cytokine cellular response to hepatocyte growth factor stimulus wound healing positive regulation of T cell proliferation T cell activation regulation of cell proliferation response to drug positive regulation of tyrosine phosphorylation of STAT protein glucose homeostasis defense response to protozoan regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to amino acid positive regulation of MAPK cascade negative regulation of chemokine biosynthetic process regulation of circadian sleep/wake cycle, non-REM sleep positive regulation of interleukin-17 biosynthetic process positive regulation of nitric oxide biosynthetic process cell redox homeostasis positive regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation negative regulation of gluconeogenesis positive regulation of translation positive regulation of DNA replication negative regulation of bone resorption negative regulation of membrane potential positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade response to antibiotic muscle cell cellular homeostasis bone remodeling negative regulation of hormone secretion negative regulation of muscle organ development positive regulation of smooth muscle cell proliferation positive regulation of epithelial cell proliferation negative regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation positive regulation of B cell activation positive regulation of immunoglobulin secretion positive regulation of sequence-specific DNA binding transcription factor activity response to glucocorticoid response to calcium ion response to electrical stimulus defense response to virus positive regulation of protein kinase B signaling positive regulation of transmission of nerve impulse positive regulation of glial cell proliferation branching involved in salivary gland morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis glucagon secretion interleukin-6-mediated signaling pathway cellular response to hydrogen peroxide positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to cytokine stimulus cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to estradiol stimulus cellular response to dexamethasone stimulus positive regulation of cell proliferation in bone marrow T-helper 17 cell lineage commitment positive regulation of extracellular matrix disassembly negative regulation of neuron death positive regulation of apoptotic DNA fragmentation cellular response to prolactin positive regulation of T-helper 2 cell cytokine production negative regulation of interleukin-1-mediated signaling pathway uc008wuu.1 uc008wuu.2 uc008wuu.3 
ENSMUST00000026846.11 Tyms ENSMUST00000026846.11 thymidylate synthase, transcript variant 2 (from RefSeq NR_033402.1) ENSMUST00000026846.1 ENSMUST00000026846.10 ENSMUST00000026846.2 ENSMUST00000026846.3 ENSMUST00000026846.4 ENSMUST00000026846.5 ENSMUST00000026846.6 ENSMUST00000026846.7 ENSMUST00000026846.8 ENSMUST00000026846.9 NR_033402 Q544L2 Q544L2_MOUSE Tyms uc008wux.1 uc008wux.2 uc008wux.3 uc008wux.4 This gene encodes an enzyme that catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor. This function maintains the thymidine-5-prime monophosphate concentration critical for DNA replication and repair. The encoded enzyme is a target for cancer chemotherapeutic agents. The majority of transcripts for this gene lack a 3' UTR (PMID: 3022294, 3444407). The stop codon in these transcripts is UAA, compared to the UAG found in the genome and longer transcripts, as the polyA site is located within the stop codon (PMID: 3444407, 2157203). A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Mar 2010]. Pyrimidine metabolism; dTTP biosynthesis. Belongs to the thymidylate synthase family. nucleotide binding translation repressor activity, nucleic acid binding mRNA binding thymidylate synthase activity folic acid binding nucleus nucleolus cytoplasm mitochondrion mitochondrial inner membrane mitochondrial matrix pyrimidine nucleobase metabolic process dTMP biosynthetic process regulation of translation aging circadian rhythm drug binding response to toxic substance response to organic cyclic compound negative regulation of translation immortalization of host cell by virus uracil metabolic process methylation response to progesterone response to vitamin A response to cytokine tetrahydrofolate interconversion response to drug protein homodimerization activity response to ethanol dUMP metabolic process tetrahydrofolate metabolic process response to organophosphorus cofactor binding developmental growth cartilage development response to glucocorticoid response to folic acid intestinal epithelial cell maturation liver regeneration sequence-specific mRNA binding uc008wux.1 uc008wux.2 uc008wux.3 uc008wux.4 
ENSMUST00000026858.11 Plk4 ENSMUST00000026858.11 polo like kinase 4, transcript variant 3 (from RefSeq NR_045576.2) ENSMUST00000026858.1 ENSMUST00000026858.10 ENSMUST00000026858.2 ENSMUST00000026858.3 ENSMUST00000026858.4 ENSMUST00000026858.5 ENSMUST00000026858.6 ENSMUST00000026858.7 ENSMUST00000026858.8 ENSMUST00000026858.9 NR_045576 PLK4_MOUSE Plk4 Q3UVA3 Q64702 Q6PEP6 Q78EG6 Q80UT6 Q8R0I5 Q9CVR6 Q9CVU6 Sak Stk18 uc008pbo.1 uc008pbo.2 uc008pbo.3 This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to the nucleolus during G2, to centrosomes during G2/M, and to the cleavage furrow during cytokinesis. It is required for progression through mitosis, cell survival, and embryonic development. The mouse genome contains a pseudogene similar to this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Phosphorylates CDC25C and CHEK2. Also involved in deuterosome- mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (By similarity). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.21; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.21; Evidence=; Homodimer (PubMed:12352953). Interacts with CEP152 (via N- terminus). Interacts with CEP78; this interaction may be important for proper PLK4 localization to the centriole and PLK4-induced overduplication of centrioles. Interacts with CEP131. Interacts simultaneously with TENT5C and CEP192. Interacts with TENT5C; this interaction leads to the TENT5C recruitment in the centrosome (By similarity). Interacts with CEP85; this interaction may be important in cell migration and centriole assembly (By similarity). Q64702; Q64702: Plk4; NbExp=4; IntAct=EBI-2552433, EBI-2552433; Q64702; Q8WWL7: CCNB3; Xeno; NbExp=4; IntAct=EBI-2552433, EBI-767764; Q64702; P02686-1: MBP; Xeno; NbExp=2; IntAct=EBI-2552433, EBI-7056012; Q64702; P03772; Xeno; NbExp=2; IntAct=EBI-2552433, EBI-4478820; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Nucleus, nucleolus Cleavage furrow Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Associates with centrioles throughout the cell cycle. According to PubMed:11301255, it localizes to the nucleolus during G2, to the centrosomes in G2/M, and to the cleavage furrow during cytokinesis. Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Sak-a; IsoId=Q64702-1; Sequence=Displayed; Name=2; Synonyms=Sak-b; IsoId=Q64702-2; Sequence=VSP_011369, VSP_011370; Name=3; IsoId=Q64702-3; Sequence=VSP_011371; expressed in tissues associated with mitotic and meiotic cell division. Highly expressed in testis. Cryptic POLO box 1 (CPB1) and Cryptic POLO box 2 (CPB2) domains can simultaneously bind to both TENT5C and CEP192. Ubiquitinated; leading to its degradation by the proteasome. Tyrosine-phosphorylated by TEC. Acetylation by KAT2A and KAT2B impairs kinase activity by shifting the kinase to an inactive conformation. Death during embryogenesis. Embryos arrest after gastrulation at E7.5, with a marked increase in mitotic and apoptotic cells. Heterozygous mice are viable but show increased liver and lung cancers in elderly mice. Defects in heterozygous mice are associated with progressive cell cycle delays, increased spindle irregularities and accelerated hepatocellular carcinogenesis, probably due to increased centrosomal amplification, multipolar spindle formation and aneuploidy. The incidence of spontaneous. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. Sequence=AAH51483.1; Type=Erroneous initiation; Evidence=; nucleotide binding mitotic cell cycle spindle pole XY body protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleolus cytoplasm centrosome centriole cytosol cytoskeleton protein phosphorylation centriole replication kinase activity phosphorylation transferase activity cleavage furrow regulation of cytokinesis identical protein binding positive regulation of centriole replication trophoblast giant cell differentiation de novo centriole assembly involved in multi-ciliated epithelial cell differentiation deuterosome uc008pbo.1 uc008pbo.2 uc008pbo.3 
ENSMUST00000026859.11 Mfsd8 ENSMUST00000026859.11 major facilitator superfamily domain containing 8 (from RefSeq NM_028140.5) ENSMUST00000026859.1 ENSMUST00000026859.10 ENSMUST00000026859.2 ENSMUST00000026859.3 ENSMUST00000026859.4 ENSMUST00000026859.5 ENSMUST00000026859.6 ENSMUST00000026859.7 ENSMUST00000026859.8 ENSMUST00000026859.9 MFSD8_MOUSE Mfsd8 NM_028140 Q8BH31 Q91VS1 Q9CZ06 uc008pbp.1 uc008pbp.2 uc008pbp.3 Outward-rectifying chloride channel involved in endolysosomal chloride homeostasis, membrane fusion and function. Conducts chloride currents up to hundreds of picoamperes. Regulates lysosomal calcium content by reducing the lysosomal membrane potential, thereby activating TRPML1 channel and further release of lysosomal calcium ions. Regulates the pH in endolysosomal compartments and may contribute to progressive acidification from endosome to lysosome. Permeable to other halides such as iodide and fluoride ions. Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29825; Evidence=; Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324, ChEBI:CHEBI:16382; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66325; Evidence=; Reaction=fluoride(in) = fluoride(out); Xref=Rhea:RHEA:76159, ChEBI:CHEBI:17051; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:76161; Evidence=; Endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Note=Sorting to lysosomes involves dileucine-based motif. Retinal degeneration associated with blindness. Belongs to the major facilitator superfamily. molecular_function nucleoplasm lysosome lysosomal membrane integral component of plasma membrane lysosome organization regulation of autophagy membrane integral component of membrane intracellular membrane-bounded organelle neuron development transmembrane transport uc008pbp.1 uc008pbp.2 uc008pbp.3 
ENSMUST00000026866.15 Sclt1 ENSMUST00000026866.15 sodium channel and clathrin linker 1, transcript variant 2 (from RefSeq NR_155540.1) ENSMUST00000026866.1 ENSMUST00000026866.10 ENSMUST00000026866.11 ENSMUST00000026866.12 ENSMUST00000026866.13 ENSMUST00000026866.14 ENSMUST00000026866.2 ENSMUST00000026866.3 ENSMUST00000026866.4 ENSMUST00000026866.5 ENSMUST00000026866.6 ENSMUST00000026866.7 ENSMUST00000026866.8 ENSMUST00000026866.9 G5E861 NR_155540 Q6PAJ0 Q9CSV4 Q9CUR9 SCLT1_MOUSE Sap1 uc008pcn.1 uc008pcn.2 uc008pcn.3 Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity). Interacts with SCN10A and clathrin. Identified in a complex containing SCN10A, clathrin and SCLT1 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=G5E861-1; Sequence=Displayed; Name=2; IsoId=G5E861-2; Sequence=VSP_047144, VSP_047145; cytoplasm centrosome centriole cytoskeleton protein C-terminus binding sodium channel regulator activity clathrin binding clustering of voltage-gated sodium channels cilium assembly clathrin complex ciliary transition fiber uc008pcn.1 uc008pcn.2 uc008pcn.3 
ENSMUST00000026879.8 Gdap1 ENSMUST00000026879.8 ganglioside-induced differentiation-associated-protein 1, transcript variant 1 (from RefSeq NM_010267.4) ENSMUST00000026879.1 ENSMUST00000026879.2 ENSMUST00000026879.3 ENSMUST00000026879.4 ENSMUST00000026879.5 ENSMUST00000026879.6 ENSMUST00000026879.7 GDAP1_MOUSE NM_010267 O88741 Q8C7Q5 Q9CTN2 uc007akc.1 uc007akc.2 uc007akc.3 uc007akc.4 uc007akc.5 Regulates the mitochondrial network by promoting mitochondrial fission. Homodimer. Mitochondrion outer membrane ; Multi-pass membrane protein Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88741-1; Sequence=Displayed; Name=2; IsoId=O88741-2; Sequence=VSP_008791, VSP_008792; Expressed in brain, spinal cord, muscles and intestinal villi. In the central nervous system expressed most prominently in the cortex, cerebellum, thalamus, olfactory bulb, and spinal cord. Expressed also in sciatic nerves and in dorsal root ganglia. First expressed at embryonic stage 13 dpc. Levels then increase gradually to reach maximum levels at adulthood. Increased expression during neural differentiation. Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. Belongs to the GST superfamily. While belonging to the GST superfamily, it lacks glutathione transferase activity. mitochondrial fission cytoplasm mitochondrion mitochondrial outer membrane cytosol protein targeting to mitochondrion mitochondrion organization mitochondrial fusion membrane integral component of membrane integral component of mitochondrial outer membrane response to retinoic acid cellular response to vitamin D uc007akc.1 uc007akc.2 uc007akc.3 uc007akc.4 uc007akc.5 
ENSMUST00000026881.11 Ly96 ENSMUST00000026881.11 lymphocyte antigen 96, transcript variant 1 (from RefSeq NM_016923.2) ENSMUST00000026881.1 ENSMUST00000026881.10 ENSMUST00000026881.2 ENSMUST00000026881.3 ENSMUST00000026881.4 ENSMUST00000026881.5 ENSMUST00000026881.6 ENSMUST00000026881.7 ENSMUST00000026881.8 ENSMUST00000026881.9 Esop1 LY96_MOUSE Md2 NM_016923 Q9JHF9 uc007ajz.1 uc007ajz.2 uc007ajz.3 uc007ajz.4 Binds bacterial lipopolysaccharide (LPS) (PubMed:22532668). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10725698). Heterogeneous homomer formed from homodimers; disulfide-linked (By similarity). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:10725698, PubMed:20133493, PubMed:24380872). Binds to the extracellular domain of TLR4 (PubMed:10725698, PubMed:20133493, PubMed:24380872, PubMed:17803912, PubMed:22532668). Binds to the extracellular domain of TLR2 (By similarity). Ligand binding induces interaction with TLR4 and oligomerization of the complex (PubMed:20133493, PubMed:24380872, PubMed:22532668). Q9JHF9; Q9QUK6: Tlr4; NbExp=8; IntAct=EBI-1534566, EBI-1534575; Secreted, extracellular space creted Note=Retained in the extracellular space at the cell surface by interaction with TLR4. Highly expressed in spleen, bone marrow, thymus, liver, kidney, ovary and decidua. Detected at lower levels in testis, small intestine and skin. N-glycosylated. lipopolysaccharide binding lipopolysaccharide receptor activity immune system process protein binding extracellular region extracellular space inflammatory response intrinsic component of plasma membrane lipopolysaccharide-mediated signaling pathway positive regulation of lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide detection of lipopolysaccharide positive regulation of tumor necrosis factor production toll-like receptor 4 signaling pathway Toll-like receptor 4 binding innate immune response lipopolysaccharide receptor complex cellular response to lipopolysaccharide uc007ajz.1 uc007ajz.2 uc007ajz.3 uc007ajz.4 
ENSMUST00000026886.8 Itih5 ENSMUST00000026886.8 inter-alpha-trypsin inhibitor, heavy chain 5 (from RefSeq NM_172471.2) ENSMUST00000026886.1 ENSMUST00000026886.2 ENSMUST00000026886.3 ENSMUST00000026886.4 ENSMUST00000026886.5 ENSMUST00000026886.6 ENSMUST00000026886.7 ITIH5_MOUSE NM_172471 Q3US68 Q80VG0 Q8BJD1 uc008ihr.1 uc008ihr.2 uc008ihr.3 May act as a tumor suppressor. Secreted Belongs to the ITIH family. molecular_function serine-type endopeptidase inhibitor activity extracellular region biological_process negative regulation of peptidase activity negative regulation of endopeptidase activity hyaluronan metabolic process peptidase inhibitor activity uc008ihr.1 uc008ihr.2 uc008ihr.3 
ENSMUST00000026888.11 Taf3 ENSMUST00000026888.11 TATA-box binding protein associated factor 3 (from RefSeq NM_027748.3) ENSMUST00000026888.1 ENSMUST00000026888.10 ENSMUST00000026888.2 ENSMUST00000026888.3 ENSMUST00000026888.4 ENSMUST00000026888.5 ENSMUST00000026888.6 ENSMUST00000026888.7 ENSMUST00000026888.8 ENSMUST00000026888.9 NM_027748 Q3U490 Q3UWX2 Q5HZG4 Q8BIU8 Q99JH4 TAF3_MOUSE uc008ihl.1 uc008ihl.2 uc008ihl.3 uc008ihl.4 The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (By similarity). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (By similarity). TAF3 forms the TFIID-A module together with TAF5 and TBP (By similarity). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:17704303). The TAF3- TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:17704303). Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP- associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (By similarity). Interacts with TAF10 via histone fold (PubMed:11438666). Interacts with TAF13, TBP, SAP130 and GCN5L2 (By similarity). Interacts with TBPL2 (PubMed:17704303). Q5HZG4; Q6SJ95: Tbpl2; NbExp=3; IntAct=EBI-1561080, EBI-1571412; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5HZG4-1; Sequence=Displayed; Name=2; IsoId=Q5HZG4-2; Sequence=VSP_019736, VSP_019737; The PHD-type zinc finger mediates binding to histone H3 methyllysine at position 4 (H3K4me3). Belongs to the TAF3 family. Sequence=AAH89030.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter p53 binding protein binding nucleus nucleoplasm transcription factor TFIID complex regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter nuclear membrane negative regulation of sequence-specific DNA binding transcription factor activity metal ion binding protein heterodimerization activity maintenance of protein location in nucleus uc008ihl.1 uc008ihl.2 uc008ihl.3 uc008ihl.4 
ENSMUST00000026889.3 Gata3os ENSMUST00000026889.3 Gata3os (from geneSymbol) AK015124 ENSMUST00000026889.1 ENSMUST00000026889.2 uc289swq.1 uc289swq.2 uc289swq.3 uc289swq.1 uc289swq.2 uc289swq.3 
ENSMUST00000026890.6 Clec3b ENSMUST00000026890.6 C-type lectin domain family 3, member b (from RefSeq NM_011606.2) Clec3b ENSMUST00000026890.1 ENSMUST00000026890.2 ENSMUST00000026890.3 ENSMUST00000026890.4 ENSMUST00000026890.5 NM_011606 Q8CFZ6 Q8CFZ6_MOUSE Tna uc009sfw.1 uc009sfw.2 uc009sfw.3 ossification granular component calcium ion binding extracellular space cytoplasm heparin binding carbohydrate binding bone mineralization kringle domain binding cellular response to organic substance cellular response to transforming growth factor beta stimulus uc009sfw.1 uc009sfw.2 uc009sfw.3 
ENSMUST00000026891.5 Exosc7 ENSMUST00000026891.5 exosome component 7, transcript variant 4 (from RefSeq NM_001418863.1) ENSMUST00000026891.1 ENSMUST00000026891.2 ENSMUST00000026891.3 ENSMUST00000026891.4 EXOS7_MOUSE NM_001418863 Q4VBW5 Q9CT77 Q9D0M0 Rrp42 uc009sfv.1 uc009sfv.2 uc009sfv.3 Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity). Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with EXOSC1 (By similarity). Interacts with ZC3HAV1 (By similarity). Nucleus, nucleolus Cytoplasm Nucleus Belongs to the RNase PH family. nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA binding nucleus nucleolus cytoplasm rRNA processing rRNA catabolic process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U1 snRNA 3'-end processing U4 snRNA 3'-end processing U5 snRNA 3'-end processing exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay nuclear mRNA surveillance nuclear polyadenylation-dependent rRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent mRNA catabolic process uc009sfv.1 uc009sfv.2 uc009sfv.3 
ENSMUST00000026893.6 Tgm4 ENSMUST00000026893.6 transglutaminase 4 (prostate) (from RefSeq NM_177911.4) A0A0R4J071 A0A0R4J071_MOUSE ENSMUST00000026893.1 ENSMUST00000026893.2 ENSMUST00000026893.3 ENSMUST00000026893.4 ENSMUST00000026893.5 NM_177911 Tgm4 uc009sfo.1 uc009sfo.2 uc009sfo.3 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Belongs to the transglutaminase superfamily. Transglutaminase family. protein-glutamine gamma-glutamyltransferase activity cytoplasm Golgi apparatus peptide cross-linking metal ion binding uc009sfo.1 uc009sfo.2 uc009sfo.3 
ENSMUST00000026896.10 St8sia2 ENSMUST00000026896.10 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2, transcript variant 1 (from RefSeq NM_009181.3) ENSMUST00000026896.1 ENSMUST00000026896.2 ENSMUST00000026896.3 ENSMUST00000026896.4 ENSMUST00000026896.5 ENSMUST00000026896.6 ENSMUST00000026896.7 ENSMUST00000026896.8 ENSMUST00000026896.9 NM_009181 O35696 Q4VA47 SIA8B_MOUSE Siat8b Stx uc009hwe.1 uc009hwe.2 uc009hwe.3 uc009hwe.4 uc009hwe.5 May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression. Protein modification; protein glycosylation. O35696; Q9BY67: CADM1; Xeno; NbExp=2; IntAct=EBI-15854779, EBI-5652260; Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 29 family. Name=Functional Glycomics Gateway - GTase; Note=ST8Sia II; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_657"; Golgi membrane ganglioside biosynthetic process alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity protein binding early endosome Golgi apparatus protein glycosylation N-glycan processing sialyltransferase activity oligosaccharide metabolic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups recycling endosome sialylation uc009hwe.1 uc009hwe.2 uc009hwe.3 uc009hwe.4 uc009hwe.5 
ENSMUST00000026897.14 Slco3a1 ENSMUST00000026897.14 solute carrier organic anion transporter family, member 3a1, transcript variant 1 (from RefSeq NM_023908.2) ENSMUST00000026897.1 ENSMUST00000026897.10 ENSMUST00000026897.11 ENSMUST00000026897.12 ENSMUST00000026897.13 ENSMUST00000026897.2 ENSMUST00000026897.3 ENSMUST00000026897.4 ENSMUST00000026897.5 ENSMUST00000026897.6 ENSMUST00000026897.7 ENSMUST00000026897.8 ENSMUST00000026897.9 NM_023908 Oatp3a1 Oatpd Q3TLX2 Q3U7W0 Q505P2 Q544H3 Q8R3L5 Q9CTV3 Q9JKV0 SO3A1_MOUSE Slc21a11 uc009hwg.1 uc009hwg.2 uc009hwg.3 Putative organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormone L-thyroxine, prostanoids such as prostaglandin E1 and E2, bile acids such as taurocholate, glycolate and glycochenodeoxycholate and peptide hormones such as L-arginine vasopressin, likely operating in a tissue-specific manner (By similarity). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). Reaction=L-thyroxine(out) = L-thyroxine(in); Xref=Rhea:RHEA:71819, ChEBI:CHEBI:58448; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71820; Evidence=; Reaction=prostaglandin E1(out) = prostaglandin E1(in); Xref=Rhea:RHEA:50980, ChEBI:CHEBI:57397; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50981; Evidence=; Reaction=prostaglandin E2(out) = prostaglandin E2(in); Xref=Rhea:RHEA:50984, ChEBI:CHEBI:606564; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50985; Evidence=; Reaction=prostaglandin F2alpha(out) = prostaglandin F2alpha(in); Xref=Rhea:RHEA:50988, ChEBI:CHEBI:57404; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50989; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) = (5Z,8Z,11Z,14Z)- eicosatetraenoate(in); Xref=Rhea:RHEA:71395, ChEBI:CHEBI:32395; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71396; Evidence=; Reaction=taurocholate(out) = taurocholate(in); Xref=Rhea:RHEA:71703, ChEBI:CHEBI:36257; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71705; Evidence=; Reaction=glycocholate(out) = glycocholate(in); Xref=Rhea:RHEA:71851, ChEBI:CHEBI:29746; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71853; Evidence=; Reaction=estrone 3-sulfate(out) = estrone 3-sulfate(in); Xref=Rhea:RHEA:71835, ChEBI:CHEBI:60050; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71836; Evidence=; Reaction=argipressin(out) = argipressin(in); Xref=Rhea:RHEA:75979, ChEBI:CHEBI:194507; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75980; Evidence=; Basolateral cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Basal cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R3L5-1; Sequence=Displayed; Name=2; IsoId=Q8R3L5-2; Sequence=VSP_036839, VSP_036840; Widely expressed. By androgens in kidney and lung. In a cholestasis model, mutant mice show decreased survival rate associated with excessive accumulation of bile acids in liver. Belongs to the organo anion transporter (TC 2.A.60) family. plasma membrane integral component of plasma membrane ion transport oligopeptide transport organic anion transmembrane transporter activity basal plasma membrane cell surface sodium-independent organic anion transmembrane transporter activity organic anion transport prostaglandin transport membrane integral component of membrane apical plasma membrane oligopeptide transmembrane transport oligopeptide transmembrane transporter activity sodium-independent organic anion transport transmembrane transport uc009hwg.1 uc009hwg.2 uc009hwg.3 
ENSMUST00000026899.4 Slc25a10 ENSMUST00000026899.4 solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 (from RefSeq NM_013770.2) DIC_MOUSE Dic ENSMUST00000026899.1 ENSMUST00000026899.2 ENSMUST00000026899.3 NM_013770 Q543J6 Q99LJ9 Q9D8G8 Q9QZD8 Slc25a10 uc007mtb.1 uc007mtb.2 uc007mtb.3 uc007mtb.4 Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane (PubMed:33746082). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes (PubMed:33746082, PubMed:16027120, PubMed:30943427). Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (PubMed:33746082). Reaction=(S)-malate(in) + phosphate(out) = (S)-malate(out) + phosphate(in); Xref=Rhea:RHEA:71607, ChEBI:CHEBI:15589, ChEBI:CHEBI:43474; Evidence=; Reaction=(S)-malate(in) + malonate(out) = (S)-malate(out) + malonate(in); Xref=Rhea:RHEA:71611, ChEBI:CHEBI:15589, ChEBI:CHEBI:15792; Evidence=; Reaction=(S)-malate(in) + succinate(out) = (S)-malate(out) + succinate(in); Xref=Rhea:RHEA:29327, ChEBI:CHEBI:15589, ChEBI:CHEBI:30031; Evidence=; Reaction=(S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in); Xref=Rhea:RHEA:71615, ChEBI:CHEBI:15589, ChEBI:CHEBI:16189; Evidence=; Reaction=malonate(out) + phosphate(in) = malonate(in) + phosphate(out); Xref=Rhea:RHEA:71623, ChEBI:CHEBI:15792, ChEBI:CHEBI:43474; Evidence=; Reaction=phosphate(in) + succinate(out) = phosphate(out) + succinate(in); Xref=Rhea:RHEA:71627, ChEBI:CHEBI:30031, ChEBI:CHEBI:43474; Evidence=; Reaction=phosphate(in) + sulfate(out) = phosphate(out) + sulfate(in); Xref=Rhea:RHEA:71631, ChEBI:CHEBI:16189, ChEBI:CHEBI:43474; Evidence=; Reaction=malonate(out) + succinate(in) = malonate(in) + succinate(out); Xref=Rhea:RHEA:71667, ChEBI:CHEBI:15792, ChEBI:CHEBI:30031; Evidence=; Regulated by circadian protein CLOCK (Circadian Locomotor Output Cycles Kaput). Mitochondrion inner membrane ; Multi-pass membrane protein. Expressed at very high levels in white adipose tissue (PubMed:10567211, PubMed:33746082). And at low levels in brown adipose tissue, kidney and liver (PubMed:10567211). Belongs to the mitochondrial carrier (TC 2.A.29) family. nucleoplasm mitochondrion mitochondrial inner membrane phosphate ion transport mitochondrial transport sulfate transport phosphate ion transmembrane transporter activity sulfate transmembrane transporter activity thiosulfate transmembrane transporter activity oxaloacetate transmembrane transporter activity malate transmembrane transporter activity succinate transmembrane transporter activity secondary active transmembrane transporter activity antiporter activity thiosulfate transport oxaloacetate transport malate transport succinate transport membrane integral component of membrane mitochondrial membrane phosphate ion transmembrane transport succinate transmembrane transport malate transmembrane transport oxaloacetate(2-) transmembrane transport sulfate transmembrane transport uc007mtb.1 uc007mtb.2 uc007mtb.3 uc007mtb.4 
ENSMUST00000026902.9 Rassf3 ENSMUST00000026902.9 Ras association (RalGDS/AF-6) domain family member 3, transcript variant 1 (from RefSeq NM_138956.4) ENSMUST00000026902.1 ENSMUST00000026902.2 ENSMUST00000026902.3 ENSMUST00000026902.4 ENSMUST00000026902.5 ENSMUST00000026902.6 ENSMUST00000026902.7 ENSMUST00000026902.8 NM_138956 Q3TJ17 Q99P51 RASF3_MOUSE uc007hfs.1 uc007hfs.2 uc007hfs.3 uc007hfs.4 Cytoplasm Cytoplasm, cytoskeleton Note=Localized to microtubules in vascular endothelial cells. cytoplasm cytosol cytoskeleton microtubule plasma membrane signal transduction identical protein binding regulation of apoptotic process uc007hfs.1 uc007hfs.2 uc007hfs.3 uc007hfs.4 
ENSMUST00000026907.6 Klkb1 ENSMUST00000026907.6 kallikrein B, plasma 1 (from RefSeq NM_008455.3) ENSMUST00000026907.1 ENSMUST00000026907.2 ENSMUST00000026907.3 ENSMUST00000026907.4 ENSMUST00000026907.5 KLKB1_MOUSE Klk3 NM_008455 P26262 Pk Q8R0P5 uc012gdd.1 uc012gdd.2 uc012gdd.3 uc012gdd.4 uc012gdd.5 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric enzyme comprised of heavy and light chains. A complete deletion of the encoded protein prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding. [provided by RefSeq, May 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026555.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. Reaction=Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.; EC=3.4.21.34; Inhibited by SERPINA5. Forms a heterodimer with SERPINA5. The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds (By similarity). Secreted. Belongs to the peptidase S1 family. Plasma kallikrein subfamily. serine-type endopeptidase activity extracellular region extracellular space proteolysis inflammatory response blood coagulation hemostasis peptidase activity serine-type peptidase activity hydrolase activity plasminogen activation fibrinolysis positive regulation of fibrinolysis uc012gdd.1 uc012gdd.2 uc012gdd.3 uc012gdd.4 uc012gdd.5 
ENSMUST00000026911.6 Ccr1 ENSMUST00000026911.6 C-C motif chemokine receptor 1 (from RefSeq NM_009912.4) CCR1_MOUSE Cmkbr1 ENSMUST00000026911.1 ENSMUST00000026911.2 ENSMUST00000026911.3 ENSMUST00000026911.4 ENSMUST00000026911.5 NM_009912 P51675 Q6ZWR7 Q91VP9 uc009sgy.1 uc009sgy.2 uc009sgy.3 uc009sgy.4 Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Interacts with CREB3. Cell membrane; Multi-pass membrane protein. Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes. Belongs to the G-protein coupled receptor 1 family. phosphatidylinositol phospholipase C activity G-protein coupled receptor activity chemokine receptor activity protein binding cytoplasm plasma membrane calcium ion transport cellular calcium ion homeostasis exocytosis chemotaxis inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling external side of plasma membrane negative regulation of gene expression membrane integral component of membrane C-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding cerebellum development myeloid cell differentiation positive regulation of cell migration negative regulation of bone mineralization leukocyte chemotaxis chemokine (C-C motif) ligand 7 binding neuronal cell body positive regulation of osteoclast differentiation negative regulation of innate immune response positive regulation of calcium ion transport cell chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade chemokine (C-C motif) ligand 5 binding positive regulation of monocyte chemotaxis uc009sgy.1 uc009sgy.2 uc009sgy.3 uc009sgy.4 
ENSMUST00000026917.10 Nrp1 ENSMUST00000026917.10 neuropilin 1, transcript variant 1 (from RefSeq NM_008737.3) ENSMUST00000026917.1 ENSMUST00000026917.2 ENSMUST00000026917.3 ENSMUST00000026917.4 ENSMUST00000026917.5 ENSMUST00000026917.6 ENSMUST00000026917.7 ENSMUST00000026917.8 ENSMUST00000026917.9 NM_008737 NRP1_MOUSE Nrp Nrp1 P97333 Q6PAR3 uc009nzt.1 uc009nzt.2 uc009nzt.3 uc009nzt.4 uc009nzt.5 Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (PubMed:26503042). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (By similarity). Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity). Homodimer, and heterodimer with NRP2 (By similarity). Binds PLXNB1 (By similarity). Interacts with FER (PubMed:20133938). Interacts with VEGFA (PubMed:26503042). Interacts with ABCB8/MITOSUR in mitochondria (By similarity). P97333; P70206: Plxna1; NbExp=4; IntAct=EBI-1555129, EBI-771260; P97333; P70207: Plxna2; NbExp=3; IntAct=EBI-1555129, EBI-771272; P97333; P34152: Ptk2; NbExp=2; IntAct=EBI-1555129, EBI-77070; P97333; O08665: Sema3a; NbExp=3; IntAct=EBI-1555129, EBI-8586029; P97333; P08648: ITGA5; Xeno; NbExp=3; IntAct=EBI-1555129, EBI-1382311; Mitochondrion membrane ; Single-pass type I membrane protein Cell membrane ; Single- pass type I membrane protein Cytoplasm Nervous system. The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding. F5/8 domains mediate the recognition and binding to R/KXXR/K CendR motifs. Knockout embryos display higher susceptibility to oxidative stress in endothelium cells located in the intersomitic vessels. Belongs to the neuropilin family. angiogenesis branching involved in blood vessel morphogenesis neuron migration sprouting angiogenesis cell migration involved in sprouting angiogenesis outflow tract septum morphogenesis vascular endothelial growth factor-activated receptor activity GTPase activator activity protein binding early endosome cytosol neurofilament plasma membrane focal adhesion substrate-dependent cell migration, cell extension integrin-mediated signaling pathway multicellular organism development nervous system development axon guidance axonal fasciculation heart development motor neuron axon guidance heparin binding response to wounding animal organ morphogenesis cell surface positive regulation of endothelial cell migration membrane integral component of membrane dendrite development cell migration semaphorin receptor activity growth factor binding protein kinase binding facial nerve structural organization trigeminal nerve morphogenesis trigeminal nerve structural organization vestibulocochlear nerve structural organization nerve development branchiomotor neuron axon guidance gonadotrophin-releasing hormone neuronal migration to the hypothalamus cell differentiation axon growth cone negative regulation of axon extension retinal ganglion cell axon guidance actin cytoskeleton reorganization regulation of Cdc42 protein signal transduction substrate adhesion-dependent cell spreading cellular response to hepatocyte growth factor stimulus endothelial cell chemotaxis cellular response to vascular endothelial growth factor stimulus ventral trunk neural crest cell migration vascular endothelial growth factor signaling pathway vascular endothelial growth factor binding neuropilin signaling pathway VEGF-activated neuropilin signaling pathway positive regulation of phosphorylation neuron projection neuronal cell body negative regulation of neuron apoptotic process endothelial cell migration positive regulation of GTPase activity positive regulation of angiogenesis metal ion binding platelet-derived growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway hepatocyte growth factor receptor signaling pathway sympathetic nervous system development neuron development regulation of axon extension involved in axon guidance positive regulation of axon extension involved in axon guidance negative regulation of axon extension involved in axon guidance artery morphogenesis axon extension involved in axon guidance positive regulation of peptidyl-tyrosine phosphorylation positive chemotaxis positive regulation of filopodium assembly positive regulation of stress fiber assembly positive regulation of focal adhesion assembly axonogenesis involved in innervation dichotomous subdivision of terminal units involved in salivary gland branching angiogenesis involved in coronary vascular morphogenesis cell migration involved in coronary vasculogenesis coronary artery morphogenesis retina vasculature morphogenesis in camera-type eye renal artery morphogenesis sympathetic ganglion development trigeminal ganglion development positive regulation of ERK1 and ERK2 cascade semaphorin-plexin signaling pathway commissural neuron axon guidance positive regulation of cell migration involved in sprouting angiogenesis regulation of retinal ganglion cell axon guidance sensory neuron axon guidance sorting endosome motor neuron migration sympathetic neuron projection extension sympathetic neuron projection guidance glutamatergic synapse integral component of postsynaptic membrane positive regulation of substrate adhesion-dependent cell spreading neural crest cell migration involved in autonomic nervous system development toxin transport semaphorin-plexin signaling pathway involved in neuron projection guidance semaphorin-plexin signaling pathway involved in axon guidance positive regulation of retinal ganglion cell axon guidance VEGF-activated neuropilin signaling pathway involved in axon guidance protein localization to early endosome facioacoustic ganglion development dorsal root ganglion morphogenesis otic placode development positive regulation of actin cytoskeleton reorganization negative regulation of extrinsic apoptotic signaling pathway cardiac neural crest cell migration involved in outflow tract morphogenesis uc009nzt.1 uc009nzt.2 uc009nzt.3 uc009nzt.4 uc009nzt.5 
ENSMUST00000026927.10 Nudt5 ENSMUST00000026927.10 nudix hydrolase 5, transcript variant 1 (from RefSeq NM_016918.4) A2ATT6 ENSMUST00000026927.1 ENSMUST00000026927.2 ENSMUST00000026927.3 ENSMUST00000026927.4 ENSMUST00000026927.5 ENSMUST00000026927.6 ENSMUST00000026927.7 ENSMUST00000026927.8 ENSMUST00000026927.9 NM_016918 NUDT5_MOUSE Nudt5 Q99KM4 Q9JKX6 uc033hlk.1 uc033hlk.2 uc033hlk.3 uc033hlk.4 Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (By similarity). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10722730). Can also hydrolyze other nucleotide sugars with low activity (PubMed:10722730). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP- ribose to ATP and ribose 5-phosphate (By similarity). Nuclear ATP synthesis takes place when dephosphorylated at Thr-44 (By similarity). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). Does not play a role in U8 snoRNA decapping activity (PubMed:21070968). Binds U8 snoRNA (PubMed:21070968). Reaction=ATP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + diphosphate; Xref=Rhea:RHEA:50248, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57967, ChEBI:CHEBI:78346; EC=2.7.7.96; Evidence=; Reaction=ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+); Xref=Rhea:RHEA:10412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57967, ChEBI:CHEBI:78346, ChEBI:CHEBI:456215; EC=3.6.1.13; Evidence=; Reaction=8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate; Xref=Rhea:RHEA:32063, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:63224, ChEBI:CHEBI:63715; EC=3.6.1.58; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 3 Mg(2+) ions per subunit. ; Homodimer. Interacts with PARG. Nucleus Widely expressed. Most abundant in liver. Phosphorylation at Thr-44 is required for homodimer stability; dephosphorylation results in destabilization of the homodimer. Dephosphorylation at Thr-44 promotes the ATP-synthesis activity. Belongs to the Nudix hydrolase family. magnesium ion binding RNA binding nucleus nucleobase-containing compound metabolic process chromatin remodeling nucleoside phosphate metabolic process ribonucleoside diphosphate catabolic process transferase activity nucleotidyltransferase activity hydrolase activity nucleoside-diphosphatase activity ADP-sugar diphosphatase activity D-ribose catabolic process ribose phosphate metabolic process snoRNA binding protein homodimerization activity 8-oxo-dGDP phosphatase activity metal ion binding ADP-ribose diphosphatase activity ATP generation from poly-ADP-D-ribose m7G(5')pppN diphosphatase activity uc033hlk.1 uc033hlk.2 uc033hlk.3 uc033hlk.4 
ENSMUST00000026937.12 Iscu ENSMUST00000026937.12 iron-sulfur cluster assembly enzyme, transcript variant 1 (from RefSeq NM_025526.5) ENSMUST00000026937.1 ENSMUST00000026937.10 ENSMUST00000026937.11 ENSMUST00000026937.2 ENSMUST00000026937.3 ENSMUST00000026937.4 ENSMUST00000026937.5 ENSMUST00000026937.6 ENSMUST00000026937.7 ENSMUST00000026937.8 ENSMUST00000026937.9 ISCU_MOUSE Iscu NM_025526 Nifun Q4VBC7 Q8K344 Q9D7P6 uc008yyp.1 uc008yyp.2 uc008yyp.3 Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN- dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex. Homodimer; Tyr-36-mediated dimerization of two iron- and sulfide-containing ISCU subunit bind to the cysteine desulfurase complex (By similarity). Component of the mitochondrial core iron- sulfur cluster (ISC) complex composed of NFS1, LYRM4, NDUFAB1, ISCU, FXN, and FDX2; this complex is an heterohexamer containing two copies of each monomer (By similarity). Interacts (D-state) with NFS1 (homodimer form); each monomer interacts with the C-terminal regions of each NFS1 monomer. Interacts (monomer form) with FXN (via ferrous form); the interaction is possible when both are bound to the dimeric form of the cysteine desulfurase complex (NFS1:LYRM4) and enhances FXN interaction to the dimeric form of the cysteine desulfurase complex (NFS1:LYRM4). Interacts with GLRX5. Interacts (D-state) with HSPA9. Interacts (S-state) with HSCB; this interaction stimulates the ATPase activity of HSPA9 (By similarity). Component of a complex composed of FXN, NFS1, LYRM4 and ISCU (PubMed:21298097, PubMed:25597503). Mitochondrion Cysteine persulfide is reduced by thiol-containing molecules such as glutathione and L-cysteine. Phosphorylation at Ser-15 is required for ISCU protein stabilization in the cytosol, whereas dephosphorylation of Ser-15, due to the inhibition of mTORC1 (mammalian target of rapamycin complex 1) complex, leads to degradation of the precursor form and ultimately to a decrease in the mitochondrial mature form. Belongs to the NifU family. Previous publications report that ISCU could provide the architecture on which both [2Fe-2S] and [4Fe-4S] clusters could be assembled (By similarity). Recent reports confirm that only [2Fe-2S] clusters are formed by the core ISC assembly complex (By similarity). iron ion binding cytoplasm mitochondrion mitochondrial matrix cytosol cellular iron ion homeostasis ferrous iron binding iron-sulfur cluster assembly metal ion binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding 4 iron, 4 sulfur cluster binding binding, bridging positive regulation of mitochondrial electron transport, NADH to ubiquinone positive regulation of aconitate hydratase activity negative regulation of ferrous iron import across plasma membrane uc008yyp.1 uc008yyp.2 uc008yyp.3 
ENSMUST00000026957.4 Pramel7 ENSMUST00000026957.4 PRAME like 7 (from RefSeq NM_178250.2) ENSMUST00000026957.1 ENSMUST00000026957.2 ENSMUST00000026957.3 NM_178250 PRAL7_MOUSE Pramel7 Q7TPY5 Q810Y8 uc008koa.1 uc008koa.2 uc008koa.3 Promotes maintenance and self-renewal of pluripotent embryonic stem cells (ESCs), downstream of LIF/STAT3 (PubMed:21425410). Maintains the pluripotency state of ESCs by repressing DNA methylation through the regulation of UHRF1 stability. Mediates the proteasomal degradation of UHRF1. Is required for the establishment of the blastocyst (PubMed:28604677). Interacts with UHRF1. Seems to be specific to pluripotent tissues in the early embryo. Not detected in somatic tissues. Expressed in early embryos at the 4-cell, blastocyst (3.5 dpc) and epiblast (7 dpc) stages (PubMed:12620990, PubMed:21425410). Expression is restricted to the interior part of the morula and the inner cell mass (ICM) of the blastocyst (PubMed:21425410). Detected in primordial germ cells (at 10 dpc) and undifferentiated embryonic stem cells (PubMed:12620990, PubMed:21425410). Embryonic lethality due to a developmental arrest during the establishment of the blastocyst. Belongs to the PRAME family. Sequence=AAH52825.1; Type=Frameshift; Evidence=; Sequence=AAH52825.1; Type=Miscellaneous discrepancy; Note=Sequence of unknown origin in the N-terminal part.; Evidence=; blastocyst formation protein binding cytoplasm positive regulation of cell proliferation stem cell population maintenance negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated regulation of ERK1 and ERK2 cascade uc008koa.1 uc008koa.2 uc008koa.3 
ENSMUST00000026972.8 Fam20c ENSMUST00000026972.8 FAM20C, golgi associated secretory pathway kinase, transcript variant 1 (from RefSeq NM_030565.6) Dmp4 ENSMUST00000026972.1 ENSMUST00000026972.2 ENSMUST00000026972.3 ENSMUST00000026972.4 ENSMUST00000026972.5 ENSMUST00000026972.6 ENSMUST00000026972.7 FA20C_MOUSE Fam20c Kiaa4081 NM_030565 Q4FJP0 Q571A3 Q5MJS3 Q6PKA8 Q8JZP7 uc009afv.1 uc009afv.2 uc009afv.3 uc009afv.4 Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22900076, PubMed:22732358, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (By similarity). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (By similarity). Phosphorylates ERO1A, enhancing its activity which is required to maintain endoplasmic reticulum redox homeostasis and for oxidative protein folding (By similarity). During endoplasmic reticulum stress, phosphorylates P4HB/PDIA1 which induces a functional switch, causing P4HB to change from an oxidoreductase to a molecular chaperone (By similarity). This is critical to maintain ER proteostasis and reduce cell death under ER stress (By similarity). Phosphorylation of P4HB also promotes its interaction with ERN1, leading to reduced activity of ERN1, a key sensor for the endoplasmic reticulum unfolded protein response (By similarity). Required for osteoblast differentiation and mineralization (By similarity). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Serine/threonine protein kinase activity is increased upon interaction with FAM20A. Kinetic parameters: KM=1.5 uM for casein ; KM=78 uM for ATP ; Vmax=0.7 umol/min/mg enzyme ; Note=kcat is 52 min(-1). ; Homodimer; disulfide-linked (By similarity). Interacts with FAM20A; probably forming a heterotetramer of 2 subunits of FAM20A and 2 subunits of FAM20C (PubMed:25789606). Interacts with COPII components SEC23A and SEC24A; transport of FAM20C from the endoplasmic reticulum to the Golgi is likely to be mediated by COPII vesicles (By similarity). Golgi apparatus membrane ; Single-pass type II membrane protein Secreted Endoplasmic reticulum Note=Resides in the Golgi apparatus membrane and is secreted following propeptide cleavage. Retained in the endoplasmic reticulum (ER) in response to ER stress where it phosphorylates P4HB. In the mammary gland, expressed at higher levels in lactating mice than in virgin mice (at protein level) (PubMed:29858230). Highly expressed in the tooth. No expression in the dental pulp. At the secretory stage of amelogenesis, it is detected in the matrix of the enamel, in the ameloblasts, and within the cells adjoining the stratum intermedium (a tissue layer analogous to the stellate reticulum seen in the developing molar). Strong expression is observed in maturation stage ameloblasts and throughout the non- cornified layers of the gingival epithelium. Expressed at moderate levels in bone and at low levels in kidney, liver, brain and lung. Very low expression, if any, in spleen and skeletal muscle. In the developing tooth, initial expression observed in odontoblasts at all stages of development. At later stages, restricted expression pattern in ameloblasts. Also observed in osteoblasts in the alveolar bone. N-glycosylation is required for folding. Autophosphorylated. Propeptide cleavage by MBTPS1/S1P promotes FAM20C secretion and maximal kinase activity which is essential for efficient osteoblast differentiation and biomineralization. Mice survive to adulthood and show biomineralization defects, suc as severe amelogenesis imperfecta (AI). In addition, mice are severely hypophosphatemic and develop notable lesions in both dentin and bone. Belongs to the FAM20 family. Sequence=AAH04044.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH04044.3; Type=Frameshift; Evidence=; Sequence=AAH25814.1; Type=Erroneous initiation; Evidence=; Sequence=AAH25826.1; Type=Erroneous initiation; Evidence=; Sequence=BAD90211.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAD90211.1; Type=Frameshift; Evidence=; nucleotide binding skeletal system development protein serine/threonine kinase activity calcium ion binding ATP binding extracellular region extracellular space cytoplasm Golgi apparatus protein phosphorylation kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor manganese ion binding positive regulation of bone mineralization biomineral tissue development osteoclast maturation regulation of fibroblast growth factor receptor signaling pathway positive regulation of osteoblast differentiation ATP metabolic process metal ion binding regulation of phosphorus metabolic process enamel mineralization odontoblast differentiation dentinogenesis uc009afv.1 uc009afv.2 uc009afv.3 uc009afv.4 
ENSMUST00000026975.11 Dnaaf5 ENSMUST00000026975.11 dynein, axonemal assembly factor 5, transcript variant 1 (from RefSeq NM_001081265.2) B9EJR8 DAAF5_MOUSE Dnaaf5 ENSMUST00000026975.1 ENSMUST00000026975.10 ENSMUST00000026975.2 ENSMUST00000026975.3 ENSMUST00000026975.4 ENSMUST00000026975.5 ENSMUST00000026975.6 ENSMUST00000026975.7 ENSMUST00000026975.8 ENSMUST00000026975.9 Heatr2 NM_001081265 uc009afz.1 uc009afz.2 uc009afz.3 Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. Interacts with DNAI2; probably involved in outer arm dynein assembly. Cytoplasm Cytoplasmic granule Note=Observed only in the cytoplasm of ciliated cells and absent from cilia. Expressed in ciliated cells including ependymal cells lining the lateral ventricles and multiciliated epithelium of oviduct ampulla. Enriched in tissues with differentiating ciliated cells including 18.5 dpc trachea and bronchus. Belongs to the DNAAF5 family. cilium movement cytoplasm cell projection organization outer dynein arm assembly inner dynein arm assembly dynein intermediate chain binding motile cilium uc009afz.1 uc009afz.2 uc009afz.3 
ENSMUST00000026976.12 Get4 ENSMUST00000026976.12 golgi to ER traffic protein 4, transcript variant 1 (from RefSeq NM_026269.2) ENSMUST00000026976.1 ENSMUST00000026976.10 ENSMUST00000026976.11 ENSMUST00000026976.2 ENSMUST00000026976.3 ENSMUST00000026976.4 ENSMUST00000026976.5 ENSMUST00000026976.6 ENSMUST00000026976.7 ENSMUST00000026976.8 ENSMUST00000026976.9 GET4_MOUSE NM_026269 Q78J86 Q9D1H7 uc009agg.1 uc009agg.2 uc009agg.3 uc009agg.4 As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with BAG6; the interaction is direct and localizes BAG6 in the cytosol. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D1H7-1; Sequence=Displayed; Name=2; IsoId=Q9D1H7-2; Sequence=VSP_017653; Ubiquitinated by RNF12, leading to proteasomal degradation. When unassembled from BAG6; ubiquitinylation is modulated by BAG6 quality control role and effectuated by RNF126. Belongs to the GET4 family. nucleoplasm nucleolus cytoplasm cytosol protein insertion into ER membrane chaperone binding cytoplasmic sequestering of protein tail-anchored membrane protein insertion into ER membrane BAT3 complex maintenance of unfolded protein involved in ERAD pathway uc009agg.1 uc009agg.2 uc009agg.3 uc009agg.4 
ENSMUST00000026985.9 Cplx2 ENSMUST00000026985.9 complexin 2, transcript variant 1 (from RefSeq NM_009946.3) CPLX2_MOUSE ENSMUST00000026985.1 ENSMUST00000026985.2 ENSMUST00000026985.3 ENSMUST00000026985.4 ENSMUST00000026985.5 ENSMUST00000026985.6 ENSMUST00000026985.7 ENSMUST00000026985.8 NM_009946 O09056 P84086 Q13329 Q28184 Q32KK4 Q64386 uc029sbi.1 uc029sbi.2 Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:11163241, PubMed:23345244). Also involved in mast cell exocytosis (PubMed:11163241). Although not essential for development, seems critical for the acquisition of higher cognitive functions in the adult brain (PubMed:12915444). Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A. Cytoplasm, cytosol Presynapse Nucleus Perikaryon Note=Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation. Nervous system. Expressed predominantly in brain, where it is present in many regions, including hippocampus and cerebellum. In the retina, present at conventional amacrine cell synapses (at protein level). In the brain, expression starts at P6 and increases to reach a plateau at P20. Mice show no obvious phenotypic changes and no significant motor deficiencies. However, they show abnormalities in a number of complex behaviors including exploration, socialization, motor coordination, learning and reversal learning. Belongs to the complexin/synaphin family. SNARE binding cytoplasm cytosol neurotransmitter transport exocytosis nervous system development synaptic vesicle exocytosis syntaxin-1 binding syntaxin binding cell differentiation dendrite SNARE complex regulation of synaptic vesicle fusion to presynaptic membrane positive regulation of synaptic plasticity mast cell granule neuronal cell body terminal bouton mast cell degranulation calyx of Held synapse regulation of neurotransmitter secretion calcium-dependent protein binding synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex presynapse postsynapse glutamatergic synapse uc029sbi.1 uc029sbi.2 
ENSMUST00000026986.7 Higd2a ENSMUST00000026986.7 HIG1 domain family, member 2A (from RefSeq NM_025933.3) ENSMUST00000026986.1 ENSMUST00000026986.2 ENSMUST00000026986.3 ENSMUST00000026986.4 ENSMUST00000026986.5 ENSMUST00000026986.6 HIG2A_MOUSE NM_025933 Q9CQJ1 uc007qol.1 uc007qol.2 uc007qol.3 Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes (By similarity). Associates with cytochrome c oxidase (COX, complex IV); proposed complex component. Mitochondrion membrane ulti-pass membrane protein tochondrion inner membrane molecular_function mitochondrion mitochondrial inner membrane membrane integral component of membrane mitochondrial membrane negative regulation of apoptotic process oxidation-reduction process mitochondrial respiratory chain supercomplex assembly uc007qol.1 uc007qol.2 uc007qol.3 
ENSMUST00000026987.12 Nop16 ENSMUST00000026987.12 NOP16 nucleolar protein (from RefSeq NM_178605.4) D13Wsu177e ENSMUST00000026987.1 ENSMUST00000026987.10 ENSMUST00000026987.11 ENSMUST00000026987.2 ENSMUST00000026987.3 ENSMUST00000026987.4 ENSMUST00000026987.5 ENSMUST00000026987.6 ENSMUST00000026987.7 ENSMUST00000026987.8 ENSMUST00000026987.9 NM_178605 NOP16_MOUSE Q8C2P2 Q921K0 Q9CPT5 uc007qok.1 uc007qok.2 uc007qok.3 Nucleus, nucleolus Belongs to the NOP16 family. nucleus nucleolus ribosomal large subunit biogenesis intracellular membrane-bounded organelle uc007qok.1 uc007qok.2 uc007qok.3 
ENSMUST00000026988.11 Arl10 ENSMUST00000026988.11 ADP-ribosylation factor-like 10, transcript variant 1 (from RefSeq NM_019968.3) ARL10_MOUSE Arl10a Arm1 ENSMUST00000026988.1 ENSMUST00000026988.10 ENSMUST00000026988.2 ENSMUST00000026988.3 ENSMUST00000026988.4 ENSMUST00000026988.5 ENSMUST00000026988.6 ENSMUST00000026988.7 ENSMUST00000026988.8 ENSMUST00000026988.9 NM_019968 Q14C12 Q9QXJ4 uc007qoj.1 uc007qoj.2 uc007qoj.3 uc007qoj.4 Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTP binding cellular_component biological_process uc007qoj.1 uc007qoj.2 uc007qoj.3 uc007qoj.4 
ENSMUST00000026989.15 4833439L19Rik ENSMUST00000026989.15 RIKEN cDNA 4833439L19 gene, transcript variant 1 (from RefSeq NM_133797.4) ENSMUST00000026989.1 ENSMUST00000026989.10 ENSMUST00000026989.11 ENSMUST00000026989.12 ENSMUST00000026989.13 ENSMUST00000026989.14 ENSMUST00000026989.2 ENSMUST00000026989.3 ENSMUST00000026989.4 ENSMUST00000026989.5 ENSMUST00000026989.6 ENSMUST00000026989.7 ENSMUST00000026989.8 ENSMUST00000026989.9 Kiaa1191 NM_133797 P33MX_MOUSE P33monox Q3TJ26 Q3UMA7 Q69ZP2 Q8C1J8 Q9D4T9 Q9DBN4 uc007qof.1 uc007qof.2 uc007qof.3 uc007qof.4 uc007qof.5 Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth (By similarity). Interacts with NELFB, NOL12 and PRNP. Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DBN4-1; Sequence=Displayed; Name=2; IsoId=Q9DBN4-2; Sequence=VSP_028802, VSP_028803; Name=3; IsoId=Q9DBN4-3; Sequence=VSP_028804, VSP_028805; Expressed in neuronal pyramidal cells of the hippocampus and in the neurons of the cortex. Belongs to the P33MONOX family. Sequence=BAD32404.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; [Isoform 2]: Sequence=BAC25449.1; Type=Frameshift; Evidence=; molecular_function cytoplasm biological_process oxidoreductase activity oxidation-reduction process uc007qof.1 uc007qof.2 uc007qof.3 uc007qof.4 uc007qof.5 
ENSMUST00000026990.6 Thoc3 ENSMUST00000026990.6 THO complex 3 (from RefSeq NM_028597.3) ENSMUST00000026990.1 ENSMUST00000026990.2 ENSMUST00000026990.3 ENSMUST00000026990.4 ENSMUST00000026990.5 NM_028597 Q8VE80 Q9CWI8 THOC3_MOUSE uc007qod.1 uc007qod.2 uc007qod.3 uc007qod.4 Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity). Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Nucleus Nucleus speckle transcription export complex THO complex part of transcription export complex nuclear chromosome, telomeric region RNA binding protein binding nucleus mRNA processing mRNA export from nucleus RNA splicing nuclear speck viral mRNA export from host cell nucleus mRNA transport uc007qod.1 uc007qod.2 uc007qod.3 uc007qod.4 
ENSMUST00000026993.14 Tspan17 ENSMUST00000026993.14 tetraspanin 17 (from RefSeq NM_028841.3) ENSMUST00000026993.1 ENSMUST00000026993.10 ENSMUST00000026993.11 ENSMUST00000026993.12 ENSMUST00000026993.13 ENSMUST00000026993.2 ENSMUST00000026993.3 ENSMUST00000026993.4 ENSMUST00000026993.5 ENSMUST00000026993.6 ENSMUST00000026993.7 ENSMUST00000026993.8 ENSMUST00000026993.9 NM_028841 Q3TAQ3 Q3TAQ3_MOUSE Tspan17 uc007qpl.1 uc007qpl.2 uc007qpl.3 uc007qpl.4 Membrane ulti-pass membrane protein Belongs to the tetraspanin (TM4SF) family. membrane integral component of membrane uc007qpl.1 uc007qpl.2 uc007qpl.3 uc007qpl.4 
ENSMUST00000026994.14 Unc5a ENSMUST00000026994.14 unc-5 netrin receptor A, transcript variant 1 (from RefSeq NM_153131.5) ENSMUST00000026994.1 ENSMUST00000026994.10 ENSMUST00000026994.11 ENSMUST00000026994.12 ENSMUST00000026994.13 ENSMUST00000026994.2 ENSMUST00000026994.3 ENSMUST00000026994.4 ENSMUST00000026994.5 ENSMUST00000026994.6 ENSMUST00000026994.7 ENSMUST00000026994.8 ENSMUST00000026994.9 Kiaa1976 NM_153131 Q6PEF7 Q80T71 Q8K1S4 UNC5A_MOUSE Unc5h1 uc007qpp.1 uc007qpp.2 uc007qpp.3 Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Homodimer and homooligomer. Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC (By similarity). Interacts (via extracellular domain) with FLRT2 (via extracellular domain) (PubMed:25374360). Interacts (via extracellular domain) with FLRT3 (via extracellular domain) (PubMed:22405201). Cell membrane ; Single-pass type I membrane protein Membrane raft Cell projection, neuron projection Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K1S4-1; Sequence=Displayed; Name=2; IsoId=Q8K1S4-2; Sequence=VSP_011697; Name=3; IsoId=Q8K1S4-3; Sequence=VSP_011696; Restricted to central nervous system. The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis. Phosphorylated on cytoplasmic tyrosine residues (By similarity). Phosphorylated by PKC in vitro (By similarity). Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. C-mannosylation by DPY19L1 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface. Belongs to the unc-5 family. Sequence=BAC65857.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; netrin receptor activity cytosol plasma membrane apoptotic process signal transduction multicellular organism development axon guidance membrane integral component of membrane neuron projection development intrinsic component of plasma membrane neuron projection membrane neuronal cell body membrane anterior/posterior axon guidance netrin-activated signaling pathway cell projection membrane raft uc007qpp.1 uc007qpp.2 uc007qpp.3 
ENSMUST00000026997.12 Uimc1 ENSMUST00000026997.12 ubiquitin interaction motif containing 1, transcript variant 1 (from RefSeq NM_011307.3) A0A0R4J073 A0A0R4J073_MOUSE ENSMUST00000026997.1 ENSMUST00000026997.10 ENSMUST00000026997.11 ENSMUST00000026997.2 ENSMUST00000026997.3 ENSMUST00000026997.4 ENSMUST00000026997.5 ENSMUST00000026997.6 ENSMUST00000026997.7 ENSMUST00000026997.8 ENSMUST00000026997.9 NM_011307 Uimc1 uc007qpv.1 uc007qpv.2 uc007qpv.3 uc007qpv.4 Nucleus Belongs to the RAP80 family. nucleus double-strand break repair response to ionizing radiation nuclear body histone binding positive regulation of DNA repair negative regulation of transcription, DNA-templated K63-linked polyubiquitin binding BRCA1-A complex histone H2A K63-linked deubiquitination signal transduction involved in G2 DNA damage checkpoint uc007qpv.1 uc007qpv.2 uc007qpv.3 uc007qpv.4 
ENSMUST00000026999.10 Smad7 ENSMUST00000026999.10 SMAD family member 7 (from RefSeq NM_001042660.1) ENSMUST00000026999.1 ENSMUST00000026999.2 ENSMUST00000026999.3 ENSMUST00000026999.4 ENSMUST00000026999.5 ENSMUST00000026999.6 ENSMUST00000026999.7 ENSMUST00000026999.8 ENSMUST00000026999.9 Madh7 Madh8 NM_001042660 O35253 O88709 SMAD7_MOUSE uc008fqd.1 uc008fqd.2 uc008fqd.3 Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Interacts with COPS5. Interacts with STAMBP. Interacts with PPP1R15A (By similarity). Interacts with NEDD4L. Interacts with RNF111, AXIN1 and AXIN2. Interacts with ACVR1B, SMURF1, SMURF2 and TGFBR1; SMAD7 recruits SMURF1 and SMURF2 to the TGF-beta receptor and regulates its degradation (By similarity). Interacts with WWP1. Interacts with PDPK1 (via PH domain) (By similarity). Ubiquitinated by WWP1. Interacts with TSC22D1/TSC-22; the interaction requires TGF-beta and the interaction is inhibited by TGFBR1 (By similarity). O35253; O35625: Axin1; NbExp=2; IntAct=EBI-5274835, EBI-2365912; O35253; Q923E4: Sirt1; NbExp=6; IntAct=EBI-5274835, EBI-1802585; O35253; Q9C0C9: UBE2O; Xeno; NbExp=2; IntAct=EBI-5274835, EBI-2339946; Nucleus toplasm te=Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:15496141). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (By similarity). Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=O35253-1; Sequence=Displayed; Name=B; IsoId=O35253-2; Sequence=VSP_006181; Ubiquitous in various organs, with higher levels in brain and kidney. Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription (PubMed:11278814). Phosphorylated by PDPK1 (By similarity). Ubiquitinated by WWP1 (PubMed:15221015). Polyubiquitinated by RNF111, which is enhanced by AXIN1 and promotes proteasomal degradation (PubMed:14657019). In response to TGF-beta, ubiquitinated by SMURF1; which promotes its degradation (By similarity). Ubiquitinated by ARK2C, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling (PubMed:23610558). Acetylation prevents ubiquitination and degradation mediated by SMURF1. Belongs to the dwarfin/SMAD family. negative regulation of transcription from RNA polymerase II promoter fibrillar center ureteric bud development negative regulation of T cell cytokine production DNA binding transcription factor activity, sequence-specific DNA binding protein binding collagen binding nucleus nucleoplasm transcription factor complex cytoplasm centrosome cytosol plasma membrane cell-cell adherens junction regulation of transcription, DNA-templated transforming growth factor beta receptor signaling pathway beta-catenin binding regulation of epithelial to mesenchymal transition negative regulation of peptidyl-threonine phosphorylation negative regulation of transcription by competitive promoter binding catenin complex regulation of transforming growth factor beta receptor signaling pathway positive regulation of cell-cell adhesion negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity negative regulation of protein ubiquitination positive regulation of protein ubiquitination ubiquitin protein ligase binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of activin receptor signaling pathway macromolecular complex negative regulation of peptidyl-serine phosphorylation adherens junction assembly response to laminar fluid shear stress cellular protein complex localization type I transforming growth factor beta receptor binding intracellular signal transduction negative regulation of sequence-specific DNA binding transcription factor activity transcription regulatory region DNA binding metal ion binding activin binding artery morphogenesis protein stabilization negative regulation of ubiquitin-protein transferase activity ventricular cardiac muscle tissue morphogenesis regulation of cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane depolarization pathway-restricted SMAD protein phosphorylation negative regulation of pathway-restricted SMAD protein phosphorylation ventricular septum morphogenesis I-SMAD binding cellular response to transforming growth factor beta stimulus cellular response to leukemia inhibitory factor negative regulation of T-helper 17 type immune response negative regulation of T-helper 17 cell differentiation uc008fqd.1 uc008fqd.2 uc008fqd.3 
ENSMUST00000027009.11 Casp12 ENSMUST00000027009.11 caspase 12 (from RefSeq NM_009808.4) CASPC_MOUSE ENSMUST00000027009.1 ENSMUST00000027009.10 ENSMUST00000027009.2 ENSMUST00000027009.3 ENSMUST00000027009.4 ENSMUST00000027009.5 ENSMUST00000027009.6 ENSMUST00000027009.7 ENSMUST00000027009.8 ENSMUST00000027009.9 NM_009808 O08736 Q3TT82 uc009obx.1 uc009obx.2 uc009obx.3 uc009obx.4 Involved in the activation cascade of caspases responsible for apoptosis execution. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by two subunits (Potential). Interacts with TRAF2 under resting conditions; this interaction is reduced in ER stress conditions. O08736; Q12933: TRAF2; Xeno; NbExp=6; IntAct=EBI-6140033, EBI-355744; Mainly expressed in skeletal muscle and lung. Belongs to the peptidase C14A family. protease binding endopeptidase activity cysteine-type endopeptidase activity protein binding nucleus cytoplasm endoplasmic reticulum cytosol proteolysis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process peptidase activity cysteine-type peptidase activity positive regulation of striated muscle cell apoptotic process protein autoprocessing hydrolase activity endoplasmic reticulum unfolded protein response regulation of apoptotic process positive regulation of apoptotic process intracellular membrane-bounded organelle positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of inflammatory response intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IPAF inflammasome complex NLRP3 inflammasome complex AIM2 inflammasome complex intrinsic apoptotic signaling pathway cysteine-type endopeptidase activity involved in apoptotic signaling pathway self proteolysis cysteine-type endopeptidase activity involved in apoptotic process uc009obx.1 uc009obx.2 uc009obx.3 uc009obx.4 
ENSMUST00000027012.14 Casp4 ENSMUST00000027012.14 caspase 4, apoptosis-related cysteine peptidase, transcript variant 1 (from RefSeq NM_007609.3) C6L648 CASP4_MOUSE Casp11 Casp4 Caspl ENSMUST00000027012.1 ENSMUST00000027012.10 ENSMUST00000027012.11 ENSMUST00000027012.12 ENSMUST00000027012.13 ENSMUST00000027012.2 ENSMUST00000027012.3 ENSMUST00000027012.4 ENSMUST00000027012.5 ENSMUST00000027012.6 ENSMUST00000027012.7 ENSMUST00000027012.8 ENSMUST00000027012.9 Ich3 NM_007609 O08735 P70343 Q3TAF3 Q6P8H1 uc009obu.1 uc009obu.2 uc009obu.3 uc009obu.4 uc009obu.5 This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is 'caspase 4, apoptosis-related cysteine peptidase', this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. [provided by RefSeq, Apr 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK160328.1, AK151547.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849389, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Inflammatory caspase that acts as the effector of the non- canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis (PubMed:22002608, PubMed:23348507, PubMed:23887873, PubMed:24031018, PubMed:25119034, PubMed:30135078, PubMed:37001519). Also indirectly activates the NLRP3 and NLRP6 inflammasomes (PubMed:26320999, PubMed:30392956, PubMed:37001519). Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS, GSDMD and IL18 (PubMed:26375003, PubMed:28314590, PubMed:30392956). Effector of the non-canonical inflammasome independently of NLRP3 inflammasome and CASP1: the non- canonical inflammasome promotes pyroptosis through GSDMD cleavage without involving secretion of cytokine IL1B and IL18 (PubMed:22002608, PubMed:22895188, PubMed:23348507, PubMed:23887873, PubMed:24031018, PubMed:26320999, PubMed:26375003, PubMed:30135078, PubMed:30589883). In the non-canonical inflammasome, CASP4/CASP11 is activated by direct binding to LPS without the need of an upstream sensor (PubMed:22002608, PubMed:23348507, PubMed:25119034, PubMed:37001519). LPS-binding promotes CASP4/CASP11 activation and CASP4/CASP11-mediated cleavage of GSDMD, followed by pyroptosis of infected cells and their extrusion into the gut lumen (PubMed:22002608, PubMed:23348507, PubMed:25119034). Also indirectly promotes secretion of mature cytokines (IL1A, IL18 and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NLRP3 and NLRP6 inflammasomes (By similarity). Involved in NLRP3- dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation or cholera enterotoxin (PubMed:26320999). Involved in NLRP6 inflammasome-dependent activation in response to lipoteichoic acid (LTA), a cell-wall component of Gram- positive bacteria, which leads to CASP1 activation and IL1B and IL18 secretion (PubMed:30392956). Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (By similarity). The non-canonical inflammasome is required for innate immunity to cytosolic, but not vacuolar, bacteria (PubMed:23348507). Plays a crucial role in the restriction of S.typhimurium replication in colonic epithelial cells during infection (PubMed:25121752, PubMed:26375003, PubMed:34671164). Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752). May also act as an activator of adaptive immunity in dendritic cells, following activation by oxidized phospholipid 1- palmitoyl-2-arachidonoyl- sn-glycero-3-phosphorylcholine, an oxidized phospholipid (oxPAPC) (PubMed:27103670). Cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4/CASP11 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412, PubMed:32554464). Catalyzes cleavage and maturation of IL18 (By similarity). In contrast, it does not directly process IL1B (PubMed:8702803, PubMed:9038361). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). Reaction=Strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp-|-.; EC=3.4.22.64; Evidence=; Activated by homooligomerization induced by direct binding to cytosolic LPS, in a TLR4-independent manner (PubMed:22002608, PubMed:23348507, PubMed:23887873, PubMed:24031018, PubMed:25119034). In addition to LPS, CASP4/CASP11 may also be activated by oxidized phospholipid 1-palmitoyl-2-arachidonoyl- sn- glycero-3-phosphorylcholine, an oxidized phospholipid (oxPAPC), in dendritic cells, promoting adaptive immunity (PubMed:27103670). The role of oxPAPC is however unclear and another report suggests that oxPAPC competes with LPS-binding and inhibits the non-canonical inflammasome in macrophages (PubMed:29520027). Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-4 subunit p20) and a 10 kDa (Caspase-4 subunit p10) subunit (PubMed:32109412). Upon direct LPS-binding, forms large homooligomers, resulting in its activation (PubMed:25119034). These oligomers are often referred to as 'non- canonical inflammasomes' (PubMed:25119034). In its precursor form, interacts with TMEM214; this interaction is required for association with the endoplasmic reticulum membrane (By similarity). Interacts with CASP1 (By similarity). Interacts with NOD2 (By similarity). Interacts with Serpinb1a, Serpinb1b and Serpinb1c; these interactions regulate CASP4 activity (By similarity). [Caspase-4 subunit p20]: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-4 subunit p20) and a 10 kDa (Caspase-4 subunit p10) subunit. [Caspase-4 subunit p10]: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-4 subunit p20) and a 10 kDa (Caspase-4 subunit p10) subunit. Cytoplasm, cytosol Cytoplasm Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Mitochondrion Inflammasome Secreted Note=Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214. Released in the extracellular milieu by keratinocytes following UVB irradiation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70343-1; Sequence=Displayed; Name=2; IsoId=P70343-2; Sequence=VSP_058183, VSP_058184; Widely expressed, including in thymus, lung and spleen (at protein level). Very low levels, if any, in the brain. Up-regulated by LPS and E.coli (PubMed:8702803, PubMed:10986288, PubMed:22002608, PubMed:26375259). In LPS-induced lung inflammation, markedly up-regulated after 6 hours of treatment and decreases at 24 hours. The induction is dependent upon DDIT3/CHOP- mediated ER stress (at protein level) (PubMed:16670335). In the spleen and in bone marrow-derived macrophages, up-regulated by poly(I:C), a synthetic analog of double-stranded RNA (at protein level) (PubMed:26320999, PubMed:26375259). Also induced by IFNG and interferon-alpha. Up-regulated by R848, a TLR7 synthetic activator, and Pam3CysK4, a synthetic activator of TLR1/TLR2 (PubMed:26375259). The CARD domain mediates LPS recognition and homooligomerization. In response to activation signals, including cholera enterotoxin subunit B, infection by E.coli or S.typhimurium or endoplasmic reticulum stress, undergoes autoproteolytic cleavage. (Microbial infection) ADP-riboxanation by S.flexneri OspC3 blocks CASP4 autoprocessing, preventing CASP4 activation and ability to recognize and cleave GSDMD, thereby thwarting the inflammasome/pyroptosis-mediated defense. A variant of this gene has been observed in several 129 substrains, including 129/SvJ, 129S1/Sv, 129P3/J and 129S6/SvEvTac. This variant displays a 5-bp deletion encompassing the exon 7 splice acceptor junction. As a result, exon 7 is spliced out. Joining of exon 6 to exon 8 creates a frameshift after Pro-304 and a stop codon occurs after 5 aberrant amino acids. The mRNA may be the target of nonsense- mediated mRNA decay. It is detected only at low levels, while the corresponding protein is not detected at all in any of the 129 substrains tested. Mutant animals are largely resistant to lipopolysaccharide (LPS)-induced lethal septic shock (PubMed:22002608, PubMed:26375259, PubMed:37001519). However, they are susceptible to Burkholderia thailandensis infection, even at low bacterial doses (PubMed:26320999). During intestinal Salmonella Typhimurium infection, mutant animals display higher pathogen loads in their cecal tissues and lumen and lower levels of IL18 in cecal explants, associated with a significant reduction in cecal inflammation (PubMed:25121752). Bone- marrow-derived macrophages from knockout mice respond normally, in terms of IL1B secretion, to canonical inflammasome activators, such as ATP, monosodium urate, poly(dA:dT) double-stranded DNA, Francisella tularensis, flagellin or Pseudomonas aeruginosa, but fail to secrete IL1B in response to cholera enterotoxin subunit B or LPS (PubMed:22002608, PubMed:37001519). They also do not respond to live E.coli, C.rodentium and V.cholerae, with or without LPS priming (PubMed:22002608). [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the peptidase C14A family. immune system process cysteine-type endopeptidase activity protein binding extracellular region cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane proteolysis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response actin filament organization peptidase activity cysteine-type peptidase activity programmed cell death membrane hydrolase activity macromolecular complex ectopic germ cell programmed cell death regulation of apoptotic process neuron projection neuronal cell body innate immune response CARD domain binding positive regulation of interleukin-1 beta secretion regulation of inflammatory response inflammasome complex intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress pyroptosis IPAF inflammasome complex NLRP3 inflammasome complex scaffold protein binding AIM2 inflammasome complex intrinsic apoptotic signaling pathway cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of tumor necrosis factor-mediated signaling pathway cellular response to beta-amyloid cysteine-type endopeptidase activity involved in apoptotic process uc009obu.1 uc009obu.2 uc009obu.3 uc009obu.4 uc009obu.5 
ENSMUST00000027015.7 Casp1 ENSMUST00000027015.7 caspase 1 (from RefSeq NM_009807.2) CASP1_MOUSE ENSMUST00000027015.1 ENSMUST00000027015.2 ENSMUST00000027015.3 ENSMUST00000027015.4 ENSMUST00000027015.5 ENSMUST00000027015.6 Il1bc NM_009807 P29452 uc009obr.1 uc009obr.2 uc009obr.3 uc009obr.4 Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides (PubMed:21147462, PubMed:32109412). Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes (PubMed:21147462). Cleaves a tetrapeptide after an Asp residue at position P1 (PubMed:21147462). Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD (PubMed:32109412). In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (PubMed:18667412, PubMed:22464733, PubMed:35705808). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (By similarity). Reaction=Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.; EC=3.4.22.36; Evidence= Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit (PubMed:32109412). May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NLRP2 and whose function would be the activation of pro-inflammatory caspases (By similarity). Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis) (PubMed:34471287). Both the p10 and p20 subunits interact with MEFV (By similarity). Interacts with CARD17P/INCA and CARD18 (By similarity). Interacts with SERPINB1; this interaction regulates CASP1 activity (By similarity). [Caspase-1 subunit p20]: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit. [Caspase-1 subunit p10]: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit. P29452; Q3UP24: Nlrc4; NbExp=2; IntAct=EBI-489700, EBI-16006652; P29452; Q9EPB4: Pycard; NbExp=2; IntAct=EBI-489700, EBI-6253348; P29452; P18011: sctE; Xeno; NbExp=3; IntAct=EBI-489700, EBI-490239; P29452; Q56134: sctE1; Xeno; NbExp=2; IntAct=EBI-489700, EBI-489689; Cytoplasm Cell membrane High level expression seen in spleen and lung, low level expression seen in brain, heart, liver, kidney, testis and skeletal muscle. The two subunits are derived from the precursor sequence by an autocatalytic mechanism. Ubiquitinated via 'Lys-11'-linked polyubiquitination. Deubiquitinated by USP8. Mutants are resitant to vaccinia virus (VACV) but not vesicular somatitis virus (VSV) infection. They show lower viral loads in the lungs compared to wild type mice, they produce higher levels of type I IFN, IL6 and RSAD2/Viperin after VCAV INFECTION. Belongs to the peptidase C14A family. response to hypoxia microglial cell activation endopeptidase activity cysteine-type endopeptidase activity protein binding extracellular region nucleus cytoplasm mitochondrion cytosol plasma membrane proteolysis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process myoblast fusion memory peptidase activity cysteine-type peptidase activity response to bacterium regulation of autophagy response to organic cyclic compound membrane protein processing protein autoprocessing hydrolase activity kinase binding response to lipopolysaccharide interleukin-1 beta production positive regulation of interleukin-1 beta production macromolecular complex response to ATP response to drug identical protein binding regulation of apoptotic process neuron projection positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of circadian sleep/wake cycle, non-REM sleep CARD domain binding positive regulation of cytokine secretion positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion regulation of inflammatory response mitochondrial depolarization membrane hyperpolarization pyroptosis cellular response to lipopolysaccharide cellular response to organic substance cellular response to interferon-gamma IPAF inflammasome complex NLRP1 inflammasome complex NLRP3 inflammasome complex scaffold protein binding AIM2 inflammasome complex protease inhibitor complex apoptotic signaling pathway cysteine-type endopeptidase activity involved in apoptotic signaling pathway programmed necrotic cell death toxin transport positive regulation of tumor necrosis factor-mediated signaling pathway cysteine-type endopeptidase activity involved in apoptotic process uc009obr.1 uc009obr.2 uc009obr.3 uc009obr.4 
ENSMUST00000027027.7 Cwf19l2 ENSMUST00000027027.7 CWF19 like cell cycle control factor 2 (from RefSeq NM_027545.2) C19L2_MOUSE ENSMUST00000027027.1 ENSMUST00000027027.2 ENSMUST00000027027.3 ENSMUST00000027027.4 ENSMUST00000027027.5 ENSMUST00000027027.6 NM_027545 Q3TIS8 Q3UX04 Q80XN7 Q8BG79 Q8BZV5 Q8C0F8 uc009oba.1 uc009oba.2 uc009oba.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BG79-1; Sequence=Displayed; Name=2; IsoId=Q8BG79-2; Sequence=VSP_030594, VSP_030595; Belongs to the CWF19 family. Sequence=BAC28298.1; Type=Erroneous initiation; Evidence=; Sequence=BAE39768.1; Type=Erroneous initiation; Evidence=; mRNA splicing, via spliceosome molecular_function post-mRNA release spliceosomal complex uc009oba.1 uc009oba.2 uc009oba.3 
ENSMUST00000027035.10 Sox17 ENSMUST00000027035.10 SRY (sex determining region Y)-box 17, transcript variant 1 (from RefSeq NM_011441.6) ENSMUST00000027035.1 ENSMUST00000027035.2 ENSMUST00000027035.3 ENSMUST00000027035.4 ENSMUST00000027035.5 ENSMUST00000027035.6 ENSMUST00000027035.7 ENSMUST00000027035.8 ENSMUST00000027035.9 NM_011441 Q61472 Q61473 Q62248 SOX17_MOUSE Sox-17 uc007aez.1 uc007aez.2 uc007aez.3 uc007aez.4 This gene encodes a member of the Sox (Sry-related high mobility group box) family of transcription factors involved in the regulation of embryonic development. The encoded protein plays a role in the determination of cell fate and in maintaining cell identity. This gene regulates tumor angiogenesis and tumor progression. Mutations in the human gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Acts as a transcription regulator that binds target promoter DNA and bends the DNA (PubMed:8636240, PubMed:24153254, PubMed:19328208). Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3' (PubMed:8636240). Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development (PubMed:11973269, PubMed:17655922, PubMed:24153254). Required for normal development of the definitive gut endoderm (PubMed:11973269). Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries (PubMed:24153254). Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18 (PubMed:16895970). Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis (PubMed:17655922). Probable transcriptional activator in the premeiotic germ cells. [Isoform 2]: Has no DNA-binding activity, and does not function as transcriptional activator. Interacts with CTNNB1, LEF1 and TCF4. Q61473; P26233: ctnnb1; Xeno; NbExp=3; IntAct=EBI-9106822, EBI-7373758; Q61473; Q01978: tcf3; Xeno; NbExp=3; IntAct=EBI-9106822, EBI-9106902; Q61473; P15884: TCF4; Xeno; NbExp=5; IntAct=EBI-9106822, EBI-533224; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61473-1; Sequence=Displayed; Name=2; Synonyms=T-SOX17; IsoId=Q61473-2; Sequence=VSP_002204; Detected in lung and testis (PubMed:8636240). Detected in endothelial cells around small and large arteries in newborns and adults, but is barely detectable in veins (at protein level) (PubMed:24153254). Detected in the extraembryonic region of the visceral endoderm of pre-streak and early-streak embryos. Detected in the extraembryonic region of the visceral endoderm and in the definitive endoderm at 7.5 dpc. By the seven to eight somite stage, detected in the posterior endoderm, mainly in the endoderm of the midgut and hindgut invagination. Expressed in spermatogonia. The expression clearly declines from the early pachytene spermatocyte stage onward. In contrast, expression of isoform 2 (T-SOX17) begins at the pachytene spermatocyte stage and is highly accumulated in round spermatids (PubMed:11973269). Detected in arterial endothelium in embryos and yolk sac at 10.5 dpc (PubMed:24153254). The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Embryonic lethal due to defects in the development of the definite gut endoderm, aberrant heart looping and severe defects in vascular development and remodeling, including a lack of artery formation. Embryos die at about 10.5 dpc (PubMed:11973269, PubMed:17655922, PubMed:24153254). Besides, mutant embryos display a severe defect in fetal hematopoiesis (PubMed:17655922). RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis vasculogenesis metanephros development endoderm formation inner cell mass cellular morphogenesis heart looping cardiogenic plate morphogenesis embryonic heart tube morphogenesis outflow tract morphogenesis negative regulation of Wnt signaling pathway involved in heart development DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus transcription factor complex regulation of transcription, DNA-templated spermatogenesis gastrulation endoderm development endodermal cell fate determination beta-catenin binding transcription factor binding positive regulation of gene expression Wnt signaling pathway rostrocaudal neural tube patterning signal transduction involved in regulation of gene expression cell differentiation negative regulation of Wnt signaling pathway negative regulation of cell growth protein destabilization embryonic heart tube development cell migration involved in gastrulation mRNA transcription from RNA polymerase II promoter sequence-specific DNA binding transcription regulatory region DNA binding nuclear transcription factor complex regulation of cell differentiation positive regulation of cell differentiation positive regulation of protein catabolic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development embryonic organ development embryonic foregut morphogenesis stem cell differentiation stem cell fate specification protein stabilization endocardium formation regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification cardiac cell fate determination endocardial cell differentiation common bile duct development gall bladder development endodermal digestive tract morphogenesis regulation of stem cell proliferation ureter development negative regulation of canonical Wnt signaling pathway cellular response to leukemia inhibitory factor regulation of stem cell division regulation of cardiac cell fate specification uc007aez.1 uc007aez.2 uc007aez.3 uc007aez.4 
ENSMUST00000027036.11 Lypla1 ENSMUST00000027036.11 lysophospholipase 1, transcript variant 1 (from RefSeq NM_008866.3) Apt1 ENSMUST00000027036.1 ENSMUST00000027036.10 ENSMUST00000027036.2 ENSMUST00000027036.3 ENSMUST00000027036.4 ENSMUST00000027036.5 ENSMUST00000027036.6 ENSMUST00000027036.7 ENSMUST00000027036.8 ENSMUST00000027036.9 LYPA1_MOUSE NM_008866 P97823 Pla1a Q3TJZ0 Q7TPX1 Q8BWM6 uc007afh.1 uc007afh.2 uc007afh.3 Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (By similarity). Has depalmitoylating activity toward KCNMA1 (By similarity). Could also depalmitoylate ADRB2 (By similarity). Acts as a lysophospholipase hydrolyzing various lysophospholipids including lysophosphatidylcholine (lyso-PC), lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso- PI) and lysophosphatidylserine (lyso-PS)(PubMed:9139730). Has much higher thioesterase activity than lysophospholipase activity (By similarity). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (By similarity). Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; EC=3.1.2.22; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57875, ChEBI:CHEBI:78421; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41721; Evidence=; Homodimer. Cytoplasm Cell membrane Nucleus membrane Endoplasmic reticulum Note=Shows predominantly a cytoplasmic localization with a weak expression in the cell membrane, nuclear membrane and endoplasmic reticulum. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P97823-1; Sequence=Displayed; Name=2; IsoId=P97823-2; Sequence=VSP_009197; [Isoform 2]: May be due to an intron retention. Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. Sequence=BAC34318.1; Type=Erroneous initiation; Evidence=; protein depalmitoylation lysophospholipase activity cytoplasm mitochondrion cytosol lipid metabolic process fatty acid metabolic process palmitoyl-(protein) hydrolase activity lipase activity hydrolase activity negative regulation of Golgi to plasma membrane protein transport carboxylic ester hydrolase activity uc007afh.1 uc007afh.2 uc007afh.3 
ENSMUST00000027040.13 Rb1cc1 ENSMUST00000027040.13 RB1-inducible coiled-coil 1 (from RefSeq NM_009826.4) Cc1 E9QLQ2 ENSMUST00000027040.1 ENSMUST00000027040.10 ENSMUST00000027040.11 ENSMUST00000027040.12 ENSMUST00000027040.2 ENSMUST00000027040.3 ENSMUST00000027040.4 ENSMUST00000027040.5 ENSMUST00000027040.6 ENSMUST00000027040.7 ENSMUST00000027040.8 ENSMUST00000027040.9 Kiaa0203 NM_009826 Q3TXX2 Q61384 Q8BRY9 Q9ESK9 Q9JK14 RBCC1_MOUSE Rb1cc1 uc007afr.1 uc007afr.2 uc007afr.3 uc007afr.4 Involved in autophagy (PubMed:23262492, PubMed:19258318). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225, PubMed:23285000, PubMed:19258318). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (PubMed:21525242). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (PubMed:21807966). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (By similarity). Plays a role as a modulator of TGF-beta- signaling by restricting substrate specificity of RNF111 (PubMed:21795712). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:15968549). Plays a crucial role in muscular differentiation (PubMed:15968549). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (PubMed:19940130, PubMed:21088496). Part of a complex containing ATG13/KIAA0652, ULK1 and RB1CC1 (PubMed:19258318). This complex associates with ATG101 (By similarity). Interacts with PTK2/FAK1 and PTK2B/PYK2 (By similarity). Interacts with GABARAP and GABARAPL1 (By similarity). Interacts with ATG16L1; the interaction is required for ULK1 complex-dependent autophagy (PubMed:23392225, PubMed:23262492). Interacts with RNF111, SKI and SMAD7 (PubMed:21795712). Interacts with COP1 in the cytoplasm of proliferating cells in response to UV stimulation (By similarity). Interacts with TP53 (By similarity). Interacts with C9orf72 (By similarity). Interacts with WDR45B (PubMed:28561066). Interacts with ATG13; this interaction is increased in the absence of TMEM39A (By similarity). Interacts with WIPI2 (By similarity). Interacts with TAX1BP1 (By similarity). Interacts (via phosphorylated FFAT motif) with MOSPD2 (By similarity). Q9ESK9; Q8C0J2: Atg16l1; NbExp=4; IntAct=EBI-647302, EBI-769195; Q9ESK9; Q8C0J2-3: Atg16l1; NbExp=3; IntAct=EBI-647302, EBI-16029274; Nucleus Cytoplasm, cytosol Cytoplasm Preautophagosomal structure Lysosome Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. Expressed abundantly in heart and testis, and moderately in kidney, liver and skeletal muscles. Very low expression levels in lung and spleen. Colocalizes with RB1 in various tissues. Abundantly expressed from an early stage of the embryo throughout development. Ubiquitously expressed, especially in the musculoskeletal system, heart and neural tissues. The FFAT motif is involved in the interaction with MOSPD2 and its phosphorylation regulates this interaction. Phosphorylation at Ser-733 of the FFAT motif activates interaction with MOSPD2. Sequence=BAC30793.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; autophagosome assembly pre-autophagosomal structure mitophagy liver development positive regulation of protein phosphorylation protein binding nucleus cytoplasm lysosome cytosol autophagy cell cycle heart development extrinsic component of membrane protein kinase binding pexophagy nuclear membrane pre-autophagosomal structure membrane piecemeal microautophagy of nucleus negative regulation of apoptotic process positive regulation of cell size positive regulation of JNK cascade reticulophagy glycophagy ATG1/ULK1 kinase complex negative regulation of extrinsic apoptotic signaling pathway uc007afr.1 uc007afr.2 uc007afr.3 uc007afr.4 
ENSMUST00000027049.10 Ppp1r42 ENSMUST00000027049.10 protein phosphatase 1, regulatory subunit 42, transcript variant 2 (from RefSeq NM_145692.2) ENSMUST00000027049.1 ENSMUST00000027049.2 ENSMUST00000027049.3 ENSMUST00000027049.4 ENSMUST00000027049.5 ENSMUST00000027049.6 ENSMUST00000027049.7 ENSMUST00000027049.8 ENSMUST00000027049.9 Lrrc67 NM_145692 PPR42_MOUSE Q8R1Z4 Q9D5M1 Q9DAF9 uc007ahb.1 uc007ahb.2 uc007ahb.3 uc007ahb.4 Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis. Interacts with PPP1CC isoform gamma-2; the interaction is direct. Interacts with actin, dynein, KIF5B, KIFC1 and tubulin. Associates with microtubules. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with alpha tubulin to the manchette of developing spermatids. Detected to nuclear rim in pachytene spermatocytes. Detected at nuclear surface, opposite the acrosome in elongating spermatids. Detected at the microtubule- organizing center (MTOC). Localized to the centrosomal region of late-stage spermatids. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R1Z4-1; Sequence=Displayed; Name=2; IsoId=Q8R1Z4-2; Sequence=VSP_032590, VSP_032591; Name=3; IsoId=Q8R1Z4-3; Sequence=VSP_032589; Testis-specific. Expressed in spermatids (at protein level). Testis-specific. Phosphorylated; during the first round of spermatogenesis with a marginal increase at 21 days after birth. manchette actin binding protein binding cytoplasm centrosome microtubule organizing center cytoskeleton regulation of phosphatase activity microtubule cytoskeleton tubulin binding dynein complex binding uc007ahb.1 uc007ahb.2 uc007ahb.3 uc007ahb.4 
ENSMUST00000027050.10 Cops5 ENSMUST00000027050.10 COP9 signalosome subunit 5, transcript variant 3 (from RefSeq NR_102282.1) CSN5_MOUSE Csn5 ENSMUST00000027050.1 ENSMUST00000027050.2 ENSMUST00000027050.3 ENSMUST00000027050.4 ENSMUST00000027050.5 ENSMUST00000027050.6 ENSMUST00000027050.7 ENSMUST00000027050.8 ENSMUST00000027050.9 Jab1 Kic2 NR_102282 O35864 Q3UA70 Q8C1S1 uc007ahe.1 uc007ahe.2 uc007ahe.3 uc007ahe.4 Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Promotes the proteasomal degradation of BRSK2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7 (COPS7A or COPS7B) and COPS9. The CSN complex interacts with the BRISC complex. Also exists as monomeric form. Interacts with TP53, MIF, JUN, UCHL1, NCOA1, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ITGB2 and TOP2A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with CDKN1B, HIF1A, ID1 and ID3. Interacts with IFIT3. Interacts with BRSK2 (By similarity). Interacts with ZDHHC16 (By similarity). Interacts with MINDY3 (By similarity). Interacts with FANK1; regulates the phosphorylation of JUN and the transcriptional activity of AP-1 (By similarity). Interacts with NUPR1; this interaction allows COPS5-dependent CDKN1B nuclear to cytoplasm translocation (By similarity). Cytoplasm, cytosol Nucleus Cytoplasm, perinuclear region Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Note=Nuclear localization is diminished in the presence of IFIT3. Widely expressed. The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex. The CSN complex is associated with some 'Lys-63'- specific deubiquitination. Such activity is however not mediated by the core CSN complex but by the BRCC3/BRCC36 component of the BRISC complex (By similarity). Belongs to the peptidase M67A family. CSN5 subfamily. protein deneddylation chromatin transcription coactivator activity metalloendopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated proteolysis synaptic vesicle COP9 signalosome peptidase activity metallopeptidase activity protein deubiquitination hydrolase activity NEDD8-specific protease activity enzyme binding cell junction cytoplasmic vesicle macrophage migration inhibitory factor binding negative regulation of apoptotic process synapse positive regulation of transcription from RNA polymerase II promoter regulation of JNK cascade metal ion binding perinuclear region of cytoplasm positive regulation of sequence-specific DNA binding transcription factor activity regulation of cell cycle regulation of IRE1-mediated unfolded protein response exosomal secretion uc007ahe.1 uc007ahe.2 uc007ahe.3 uc007ahe.4 
ENSMUST00000027053.8 Rdh10 ENSMUST00000027053.8 retinol dehydrogenase 10 (all-trans) (from RefSeq NM_133832.3) ENSMUST00000027053.1 ENSMUST00000027053.2 ENSMUST00000027053.3 ENSMUST00000027053.4 ENSMUST00000027053.5 ENSMUST00000027053.6 ENSMUST00000027053.7 NM_133832 Q8CJ68 Q8VCH7 RDH10_MOUSE uc007ajm.1 uc007ajm.2 uc007ajm.3 Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity). Required for normal embryonic development. Reaction=all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH; Xref=Rhea:RHEA:25033, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.300; Cofactor metabolism; retinol metabolism. Microsome membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Detected in retinal pigment epithelium (at protein level). First detected in the neural groove at 8.0 dpc. At 8.5 dpc, detected in lateral plate mesoderm, the dorsal region of the somites, the floor plate of the neural tube and in head mesenchyme. At 9.5 dpc, detected in dorsal paraxial mesoderm, lateral plate mesoderm and in nephrogenic cord tissues. At 10.5 dpc, detected in lung buds, developing mesonephros, mesodermal tissue surrounding dorsal root ganglia and adjacent to the forlimb buds. Belongs to the short-chain dehydrogenases/reductases (SDR) family. metanephros development in utero embryonic development retinoic acid biosynthetic process retinol dehydrogenase activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane lipid particle visual perception gonad development animal organ morphogenesis neural crest cell development membrane integral component of membrane oxidoreductase activity embryonic camera-type eye development organelle membrane embryonic forelimb morphogenesis retinol metabolic process retinal metabolic process intracellular membrane-bounded organelle ear development nose development embryonic organ development embryonic viscerocranium morphogenesis NADP-retinol dehydrogenase activity oxidation-reduction process primary lung bud formation bud elongation involved in lung branching positive regulation of retinoic acid biosynthetic process uc007ajm.1 uc007ajm.2 uc007ajm.3 
ENSMUST00000027056.12 Prex2 ENSMUST00000027056.12 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2, transcript variant 1 (from RefSeq NM_029525.1) Depdc2 E9QMG3 ENSMUST00000027056.1 ENSMUST00000027056.10 ENSMUST00000027056.11 ENSMUST00000027056.2 ENSMUST00000027056.3 ENSMUST00000027056.4 ENSMUST00000027056.5 ENSMUST00000027056.6 ENSMUST00000027056.7 ENSMUST00000027056.8 ENSMUST00000027056.9 NM_029525 PREX2_MOUSE Q3LAC4 Q3UQI2 Q3UU18 Q9CXD5 uc007ahs.1 uc007ahs.2 uc007ahs.3 uc007ahs.4 Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5- trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase (By similarity). Interacts with RAC1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3LAC4-1; Sequence=Displayed; Name=2; IsoId=Q3LAC4-2; Sequence=VSP_025164, VSP_025165; PH domain confers substrate specificity and recognition. Able to discriminate between RAC1, RHOA, and CDC42 (By similarity). DH domain alone was unable to confer substrate specificity and recognition. Sequence=BAB31066.1; Type=Frameshift; Evidence=; Sequence=BAE25059.1; Type=Erroneous initiation; Evidence=; guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity plasma membrane G-protein coupled receptor signaling pathway adult locomotory behavior phosphatidylinositol 3-kinase signaling Rac guanyl-nucleotide exchange factor activity regulation of Rho protein signal transduction intracellular signal transduction positive regulation of GTPase activity dendrite morphogenesis uc007ahs.1 uc007ahs.2 uc007ahs.3 uc007ahs.4 
ENSMUST00000027059.11 Tfap2b ENSMUST00000027059.11 transcription factor AP-2 beta, transcript variant 1 (from RefSeq NM_009334.4) AP2B_MOUSE ENSMUST00000027059.1 ENSMUST00000027059.10 ENSMUST00000027059.2 ENSMUST00000027059.3 ENSMUST00000027059.4 ENSMUST00000027059.5 ENSMUST00000027059.6 ENSMUST00000027059.7 ENSMUST00000027059.8 ENSMUST00000027059.9 NM_009334 Q61313 Q8CEP1 Tcfap2b uc007akr.1 uc007akr.2 uc007akr.3 uc007akr.4 Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity (By similarity). Nucleus Note=In the brain, localizes to the arcuate hypothalamic nucleus, the ventromedial hypothalamic nucleus and the accumbens nucleus of the ventral striatum. Localizes to neurons in areas of the cerebral cortex, cerebellum and hypothalamus (at protein level). Expressed from embryo day 9.5 to birth. In day 13.5 embryo, expressed abundantly in cells coating the neural tube. Expression continues posteriorly in the spinal cord, the dorsal root ganglia, in the prevertebal sympathic ganglia and the ganglion nodosum. High expression found in the dorsal and anteriolateral primordium of the midbrain. Expression also found in skin, kidneys and in many areas of the facial mesenchyme. In adults, expressed in the eye, skin, kidney, prostate, thymus, skeletal muscle and, very weakly in the brain. Highest levels found in kidney. During retinoic acid-mediated differentiation. Up-regulated by starvation and a high fat diet (PubMed:25187989). Sumoylated (PubMed:25187989). Sumoylated on Lys-21; which inhibits transcriptional activity (By similarity). Belongs to the AP-2 family. Sequence=CAA55036.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding kidney development renal water homeostasis DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity transcription corepressor activity protein binding nucleus glucose metabolic process regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter apoptotic process sensory organ development positive regulation of cell proliferation negative regulation of cell proliferation retina layer formation magnesium ion homeostasis regulation of BMP signaling pathway forelimb morphogenesis hindlimb morphogenesis positive regulation of urine volume aorta morphogenesis response to drug glucose homeostasis protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process sequence-specific DNA binding skin development fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity sympathetic nervous system development regulation of insulin secretion phosphate ion homeostasis calcium ion homeostasis potassium ion homeostasis sodium ion homeostasis distal tubule development collecting duct development metanephric nephron development ductus arteriosus closure cellular ammonia homeostasis cellular creatinine homeostasis cellular urea homeostasis uc007akr.1 uc007akr.2 uc007akr.3 uc007akr.4 
ENSMUST00000027061.5 Il17a ENSMUST00000027061.5 interleukin 17A (from RefSeq NM_010552.3) Ctla8 ENSMUST00000027061.1 ENSMUST00000027061.2 ENSMUST00000027061.3 ENSMUST00000027061.4 IL17_MOUSE Il17 NM_010552 Q60971 Q62386 uc007aky.1 uc007aky.2 This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK040420.1, U43088.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:18025225, PubMed:19144317, PubMed:26431948). Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:17911633, PubMed:16200068, PubMed:19144317, PubMed:26431948). Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (PubMed:18025225). In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines (PubMed:18025225, PubMed:27923703). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (PubMed:18157131). Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance (PubMed:17372004, PubMed:20364087, PubMed:28709803). Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation (PubMed:17470641, PubMed:23255360). Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis (PubMed:26431948). As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release (PubMed:28709803). In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317). Involved in antiviral host defense through various mechanisms (PubMed:21946434, PubMed:26735852, PubMed:27795421). Enhances immunity against West Nile virus by promoting T cell cytotoxicity (PubMed:27795421). May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung (PubMed:21946434). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (PubMed:26735852). Homodimer (PubMed:18025225). Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule (By similarity). IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex (By similarity). IL17A homodimer adopts an asymmetrical ternary structure with one IL17RA molecule, allowing for high affinity interactions of one IL17A monomer with one IL17RA molecule (via D1 and D2 domains), while disfavoring binding of a second IL17RA molecule on the other IL17A monomer (By similarity). Heterodimer with IL17F (PubMed:18025225). IL17A-IL17F forms complexes with IL17RA- IL17RC, but with lower affinity when compared to IL17A homodimer (By similarity). IL17RA and IL17RC chains cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (By similarity). Secreted Expressed by Th17 cell lineage (at protein level). The expression pattern reflects the differentiation state, with IL17A- IL17F heterodimers produced at higher levels than IL17A-IL17A and IL17F-IL17F dimers in fully differentiated Th17 cells (PubMed:18025225, PubMed:16990136). Expressed in innate lymphoid cells (at protein level) (PubMed:23255360, PubMed:28709803). Expressed in gamma-delta T cell subsets (at protein level) (PubMed:17372004, PubMed:20364087, PubMed:28709803, PubMed:26431948). Expressed in iNKT cells (at protein level) (PubMed:17470641). Induced upon differentiation of CD4-positive T cells toward Th17 effector cells upon antigen receptor binding in the presence of IL6 and TGFB1 (PubMed:16200068, PubMed:16990136, PubMed:18025225). Up- regulated by IL23A-IL12B, IL1B and TNF and inhibited by IFNG and IL4 (PubMed:16200068, PubMed:18025225). Up-regulated by pro-inflammatory cytokines in response to microbes in various immune cells: induced in innate lymphoid cells upon fungal infection, in Vdelta4-positive gamma- delta T cells upon C.mastitidis infection, in Vdelta5-positive gamma- delta T cells upon S.aureus infection and in Vdelta1-positive gamma- delta T cells upon E.coli infection (PubMed:23255360, PubMed:28709803, PubMed:20364087, PubMed:17372004). Induced in gamma-delta T cells in intestinal lamina propria upon acute injury (PubMed:26431948). Induced in KLRB1/NK1.1-negative iNKT cell subset upon CD1D stimulation (PubMed:17470641). Mutant mice are born at the expected Mendelian ratio, are fertile, and have no apparent phenotypic abnormalities. They are protected against chronic autoimmune and allergic reactions, as observed in models of spontaneous or induced rheumatoid arthritis, experimental autoimmune encephalomyelitis and chemical allergen-induced contact hypersensitivity (PubMed:19144317). In a model of acute intestinal injury, mutant mice show epithelial disruption, presence of abscesses associated with enhanced bleeding into the mucosal lumen and increased cellular infiltrate into the submucosal layer (PubMed:26431948). Mutant mice show increased susceptibility to West Nile virus infection characterized by deficient virus clearance from brain and spleen (PubMed:27795421). Mutant mice are deficient in clearing influenza A virus (H1N1) pulmonary infection due to increased immune inflammation and lung damage (PubMed:26735852). Belongs to the IL-17 family. cytokine activity extracellular region extracellular space cytoplasm inflammatory response signal transduction external side of plasma membrane positive regulation of necrotic cell death positive regulation of interleukin-23 production positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter defense response to fungus cellular response to interleukin-1 cellular response to glucocorticoid stimulus fibroblast activation granulocyte migration positive regulation of cytokine production involved in inflammatory response positive regulation of interleukin-6 secretion uc007aky.1 uc007aky.2 
ENSMUST00000027062.7 Msc ENSMUST00000027062.7 musculin, transcript variant 1 (from RefSeq NM_010827.3) ENSMUST00000027062.1 ENSMUST00000027062.2 ENSMUST00000027062.3 ENSMUST00000027062.4 ENSMUST00000027062.5 ENSMUST00000027062.6 MUSC_MOUSE Myor NM_010827 O88940 Q3ZAZ1 uc007aja.1 uc007aja.2 uc007aja.3 uc007aja.4 Transcription repressor that blocks myogenesis and activation of E-box dependent muscle genes. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer. Forms a heterodimer with TCF3. Nucleus. Expression in embryos is largely restricted to embryonic skeletal muscle lineage. First detected at 9.5 dpc in cells within the first and second branchial arches. At 10.5 dpc, expression was also observed in the myotomal compartment of rostral somites and by 11.5 dpc in myotomes along the whole anterio-posterior axis, as well as in cells within the developing forelimbs and hindlimbs. At 12.5-14.5 dpc, expression was confined to the skeletal muscle lineage (head, neck, trunk, limbs and diaphragm but not cardiac and smooth muscle). At 15 dpc, a peak expression was seen in neonatal limbs. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus nucleoplasm branchiomeric skeletal muscle development protein dimerization activity palate development diaphragm development cellular response to leukemia inhibitory factor uc007aja.1 uc007aja.2 uc007aja.3 uc007aja.4 
ENSMUST00000027065.12 Tmem14a ENSMUST00000027065.12 transmembrane protein 14A, transcript variant 2 (from RefSeq NM_029398.3) ENSMUST00000027065.1 ENSMUST00000027065.10 ENSMUST00000027065.11 ENSMUST00000027065.2 ENSMUST00000027065.3 ENSMUST00000027065.4 ENSMUST00000027065.5 ENSMUST00000027065.6 ENSMUST00000027065.7 ENSMUST00000027065.8 ENSMUST00000027065.9 NM_029398 P56983 Q8JZZ3 TM14A_MOUSE uc007alj.1 uc007alj.2 uc007alj.3 Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Mitochondrion membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane Belongs to the TMEM14 family. molecular_function mitochondrion endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane mitochondrial membrane negative regulation of apoptotic process negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway uc007alj.1 uc007alj.2 uc007alj.3 
ENSMUST00000027066.13 Eya1 ENSMUST00000027066.13 EYA transcriptional coactivator and phosphatase 1, transcript variant 7 (from RefSeq NM_001402662.1) ENSMUST00000027066.1 ENSMUST00000027066.10 ENSMUST00000027066.11 ENSMUST00000027066.12 ENSMUST00000027066.2 ENSMUST00000027066.3 ENSMUST00000027066.4 ENSMUST00000027066.5 ENSMUST00000027066.6 ENSMUST00000027066.7 ENSMUST00000027066.8 ENSMUST00000027066.9 EYA1_MOUSE G5E864 NM_001402662 O08818 P97767 uc057auc.1 uc057auc.2 uc057auc.3 Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:10490620). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (PubMed:14628042). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (PubMed:10471511). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (PubMed:17098221). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Probably interacts with SIX2, SIX4 and SIX5. Interacts with H2AX in response to DNA damage. Interacts with SIX3; promotes EYA1 translocation to the nucleus. P97767; Q9WUB0: Rbck1; NbExp=2; IntAct=EBI-1368503, EBI-6141072; P97767; Q91WA6: Sharpin; NbExp=4; IntAct=EBI-1368503, EBI-646097; P97767; Q62231: Six1; NbExp=3; IntAct=EBI-1368503, EBI-1368483; P97767; Q62232: Six2; NbExp=3; IntAct=EBI-1368503, EBI-1368736; Cytoplasm Nucleus Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P97767-1; Sequence=Displayed; Name=2; IsoId=P97767-2; Sequence=VSP_001487, VSP_001488; Extensively expressed in cranial placodes, branchial arches, CNS and developing eye and nose. Sumoylated with SUMO1. Note=A spontaneous mutation leading to decreased Eya1 expression gives rise to the Eya1-bor phenotype. It is characterized by circling behavior and deafness, due to gross morphological abnormalities of the inner ear, and dysmorphic or missing kidneys. This autosomal recessive trait resembles human branchio-oto-renal (BOR) syndrome. Complete perinatal lethality in homozygotes, due to severe craniofacial and skeletal defects, combined with an absence of thymus, kidneys, parotid glands and ears. Mice present multiple skeletal defects in skull, neck, rib and pelvic girdle, but no major defects in muscle development. Otic anomalies involve the inner, middle and outer ears, with malformed auricles and eardrums, malformations of the incus, malleus, and stapes, while the tympanic cavity never formed. Likewise, mice display an absence of inner ear structures. Heterozygotes present milder symptoms with low penetrance, including renal defects, similar to human BOR (branchio-oto-renal) syndrome. Increased apoptosis and loss of renal tubules seen in the developing kidney with increased immunostaining for 'Ser-139' phosphorylated H2AX. Mice lacking both Six1 and Eya1 show defects in kidney development, complete absence of hypaxial muscle, severe reduction in epaxial muscle and a 5-10-fold by volume smaller pituarity than the wild-type gland. Mice lacking both Eya1 and Eya2 display complete embryonic lethality, due to severe defects in muscle development, including the absence of a diaphragm and of ventral hypaxial muscles of the trunk and the complete absence of muscles in forelimbs and hindlimbs, similar to the phenotype of mice lacking both Six1 and Six4. While Six1 is normally expressed in these mice, it does not active transcription from cognate promoter elements, and does not activate transcription of Pax3. Belongs to the HAD-like hydrolase superfamily. EYA family. Sequence=AAB48017.1; Type=Frameshift; Evidence=; metanephros development ureteric bud development branching involved in ureteric bud morphogenesis outflow tract morphogenesis RNA binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding nucleus nucleoplasm cytoplasm DNA repair double-strand break repair chromatin organization protein dephosphorylation cellular response to DNA damage stimulus multicellular organism development pattern specification process mesodermal cell fate specification animal organ morphogenesis response to ionizing radiation striated muscle tissue development histone dephosphorylation nuclear body hydrolase activity protein sumoylation macromolecular complex protein-DNA complex peptidyl-tyrosine dephosphorylation aorta morphogenesis ear morphogenesis inner ear morphogenesis outer ear morphogenesis middle ear morphogenesis cell fate commitment regulation of neuron differentiation positive regulation of DNA repair positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding neuron fate specification embryonic skeletal system morphogenesis semicircular canal morphogenesis anatomical structure development positive regulation of epithelial cell proliferation pharyngeal system development otic vesicle development otic vesicle morphogenesis positive regulation of secondary heart field cardioblast proliferation cochlea morphogenesis negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc057auc.1 uc057auc.2 uc057auc.3 
ENSMUST00000027067.15 Gsta3 ENSMUST00000027067.15 glutathione S-transferase, alpha 3, transcript variant 2 (from RefSeq NM_010356.5) ENSMUST00000027067.1 ENSMUST00000027067.10 ENSMUST00000027067.11 ENSMUST00000027067.12 ENSMUST00000027067.13 ENSMUST00000027067.14 ENSMUST00000027067.2 ENSMUST00000027067.3 ENSMUST00000027067.4 ENSMUST00000027067.5 ENSMUST00000027067.6 ENSMUST00000027067.7 ENSMUST00000027067.8 ENSMUST00000027067.9 GSTA3_MOUSE Gsta3 Gstyc NM_010356 P30115 Q544Y6 uc007all.1 uc007all.2 uc007all.3 uc007all.4 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively (By similarity). Has a high catalytic activity for aflatoxin B1-8,9 epoxide (PubMed:1637297). Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16438; Evidence=; Reaction=androst-5-ene-3,17-dione = androst-4-ene-3,17-dione; Xref=Rhea:RHEA:43936, ChEBI:CHEBI:16422, ChEBI:CHEBI:83865; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43937; Evidence=; Reaction=pregn-5-ene-3,20-dione = progesterone; Xref=Rhea:RHEA:43928, ChEBI:CHEBI:17026, ChEBI:CHEBI:63837; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43929; Evidence=; Homodimer. Cytoplasm. Mass=25271.4; Mass_error=2; Method=Electrospray; Evidence=; Belongs to the GST superfamily. Alpha family. ureteric bud development glutathione transferase activity cytoplasm cytosol glutathione metabolic process xenobiotic metabolic process transferase activity aflatoxin catabolic process uc007all.1 uc007all.2 uc007all.3 uc007all.4 
ENSMUST00000027068.11 Tram1 ENSMUST00000027068.11 translocating chain-associating membrane protein 1 (from RefSeq NM_028173.5) ENSMUST00000027068.1 ENSMUST00000027068.10 ENSMUST00000027068.2 ENSMUST00000027068.3 ENSMUST00000027068.4 ENSMUST00000027068.5 ENSMUST00000027068.6 ENSMUST00000027068.7 ENSMUST00000027068.8 ENSMUST00000027068.9 NM_028173 Q91V04 TRAM1_MOUSE Tram Tram1 uc007ait.1 uc007ait.2 uc007ait.3 uc007ait.4 This gene encodes a multi-pass transmembrane protein of the endoplasmic reticulum (ER). It is involved in the process of cotranslational translocation of secretory proteins into the ER. [provided by RefSeq, Dec 2014]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.188688.1, SRR1660813.218567.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel. Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER. May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport. Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane. Associates with the second TM domain of G-protein- coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane. Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER- membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome. Interacts with SEC61B. May interact with Derlin-1/DERL1. Endoplasmic reticulum membrane ; Multi-pass membrane protein N-glycosylated. Belongs to the TRAM family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane rough endoplasmic reticulum SRP-dependent cotranslational protein targeting to membrane, translocation protein transport membrane integral component of membrane integral component of endoplasmic reticulum membrane uc007ait.1 uc007ait.2 uc007ait.3 uc007ait.4 
ENSMUST00000027071.7 Lactb2 ENSMUST00000027071.7 lactamase, beta 2, transcript variant 8 (from RefSeq NR_184545.1) ENSMUST00000027071.1 ENSMUST00000027071.2 ENSMUST00000027071.3 ENSMUST00000027071.4 ENSMUST00000027071.5 ENSMUST00000027071.6 LACB2_MOUSE NR_184545 Q99KR3 uc007aiu.1 uc007aiu.2 uc007aiu.3 uc007aiu.4 uc007aiu.5 Endoribonuclease; cleaves preferentially 3' to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double- stranded RNA or DNA. Required for normal mitochondrial function and cell viability. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Monomer. Mitochondrion matrix Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. RNA binding single-stranded RNA binding nuclease activity endonuclease activity endoribonuclease activity mitochondrion mitochondrial matrix zinc ion binding hydrolase activity metal ion binding RNA phosphodiester bond hydrolysis, endonucleolytic uc007aiu.1 uc007aiu.2 uc007aiu.3 uc007aiu.4 uc007aiu.5 
ENSMUST00000027082.11 Crygf ENSMUST00000027082.11 crystallin, gamma F, transcript variant 1 (from RefSeq NM_027010.3) CRGF_MOUSE ENSMUST00000027082.1 ENSMUST00000027082.10 ENSMUST00000027082.2 ENSMUST00000027082.3 ENSMUST00000027082.4 ENSMUST00000027082.5 ENSMUST00000027082.6 ENSMUST00000027082.7 ENSMUST00000027082.8 ENSMUST00000027082.9 NM_027010 Q9CXV3 uc007bhv.1 uc007bhv.2 uc007bhv.3 Crystallins are the dominant structural components of the vertebrate eye lens. In the embryo, expressed by day 12 of gestation. Maximum levels are found at day 30-40 followed by a rapid decline. Has a two-domain beta-structure, folded into four very similar Greek key motifs. There are six different gamma crystallins identified in mouse lens. Belongs to the beta/gamma-crystallin family. eye development lens development in camera-type eye structural constituent of eye lens visual perception uc007bhv.1 uc007bhv.2 uc007bhv.3 
ENSMUST00000027083.7 Pth2r ENSMUST00000027083.7 parathyroid hormone 2 receptor (from RefSeq NM_139270.2) ENSMUST00000027083.1 ENSMUST00000027083.2 ENSMUST00000027083.3 ENSMUST00000027083.4 ENSMUST00000027083.5 ENSMUST00000027083.6 NM_139270 PTH2R_MOUSE Pthr2 Q91V95 uc007bhu.1 uc007bhu.2 This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). Binds to TIPF39/TIP39. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 2 family. transmembrane signaling receptor activity G-protein coupled receptor activity parathyroid hormone receptor activity plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane peptide hormone binding uc007bhu.1 uc007bhu.2 
ENSMUST00000027089.15 Crygc ENSMUST00000027089.15 crystallin, gamma C, transcript variant 1 (from RefSeq NM_007775.2) CRGC_MOUSE ENSMUST00000027089.1 ENSMUST00000027089.10 ENSMUST00000027089.11 ENSMUST00000027089.12 ENSMUST00000027089.13 ENSMUST00000027089.14 ENSMUST00000027089.2 ENSMUST00000027089.3 ENSMUST00000027089.4 ENSMUST00000027089.5 ENSMUST00000027089.6 ENSMUST00000027089.7 ENSMUST00000027089.8 ENSMUST00000027089.9 Gammab-cry NM_007775 Q03739 Q61597 uc007bhi.1 uc007bhi.2 uc007bhi.3 uc007bhi.4 Crystallins are the dominant structural components of the vertebrate eye lens. Has a two-domain beta-structure, folded into four very similar Greek key motifs. There are six different gamma crystallins identified in mouse lens. Belongs to the beta/gamma-crystallin family. eye development lens development in camera-type eye structural constituent of eye lens nucleus cytoplasm visual perception camera-type eye development uc007bhi.1 uc007bhi.2 uc007bhi.3 uc007bhi.4 
ENSMUST00000027090.9 Crygb ENSMUST00000027090.9 crystallin, gamma B (from RefSeq NM_144761.2) CRGB_MOUSE ENSMUST00000027090.1 ENSMUST00000027090.2 ENSMUST00000027090.3 ENSMUST00000027090.4 ENSMUST00000027090.5 ENSMUST00000027090.6 ENSMUST00000027090.7 ENSMUST00000027090.8 NM_144761 P04344 Q61593 Q6PHP7 uc007bhj.1 uc007bhj.2 uc007bhj.3 uc007bhj.4 Crystallins are the dominant structural components of the vertebrate eye lens. Has a two-domain beta-structure, folded into four very similar Greek key motifs. There are six different gamma crystallins identified in mouse lens. Belongs to the beta/gamma-crystallin family. eye development lens development in camera-type eye structural constituent of eye lens nucleus cytoplasm visual perception lens fiber cell development lens fiber cell morphogenesis uc007bhj.1 uc007bhj.2 uc007bhj.3 uc007bhj.4 
ENSMUST00000027102.3 4933402D24Rik ENSMUST00000027102.3 RIKEN cDNA 4933402D24 gene (from RefSeq NR_177954.1) ENSMUST00000027102.1 ENSMUST00000027102.2 NR_177954 uc029qow.1 uc029qow.2 uc029qow.3 uc029qow.4 uc029qow.1 uc029qow.2 uc029qow.3 uc029qow.4 
ENSMUST00000027103.7 Fastkd2 ENSMUST00000027103.7 FAST kinase domains 2 (from RefSeq NM_172422.3) ENSMUST00000027103.1 ENSMUST00000027103.2 ENSMUST00000027103.3 ENSMUST00000027103.4 ENSMUST00000027103.5 ENSMUST00000027103.6 FAKD2_MOUSE NM_172422 Q3TLQ2 Q3U526 Q3UFY6 Q8BT79 Q8C3T6 Q922E6 uc007bgl.1 uc007bgl.2 uc007bgl.3 uc007bgl.4 Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. May play a role in mitochondrial apoptosis. Monomer. Found in a complex with GRSF1, DDX28, DHX30 and FASTKD5. Associates with the 16S mitochondrial rRNA (16S mt-rRNA). Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Mitochondrion matrix Mitochondrion matrix, mitochondrion nucleoid Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. Ubiquitously expressed (PubMed:18771761). Expression detected in spleen, testis, colon, heart, smooth muscle, kidney, brain, lung, liver, brown and white adipose tissue with highest expression in testis, heart and smooth muscle. Belongs to the FAST kinase family. RNA binding protein kinase activity nucleus mitochondrion protein phosphorylation rRNA binding ribonucleoprotein granule ribosome biogenesis mitochondrial nucleoid intercellular bridge positive regulation of mitochondrial translation mitochondrial large ribosomal subunit assembly uc007bgl.1 uc007bgl.2 uc007bgl.3 uc007bgl.4 
ENSMUST00000027111.15 Ndufs1 ENSMUST00000027111.15 NADH:ubiquinone oxidoreductase core subunit S1, transcript variant 4 (from RefSeq NM_145518.2) ENSMUST00000027111.1 ENSMUST00000027111.10 ENSMUST00000027111.11 ENSMUST00000027111.12 ENSMUST00000027111.13 ENSMUST00000027111.14 ENSMUST00000027111.2 ENSMUST00000027111.3 ENSMUST00000027111.4 ENSMUST00000027111.5 ENSMUST00000027111.6 ENSMUST00000027111.7 ENSMUST00000027111.8 ENSMUST00000027111.9 NDUS1_MOUSE NM_145518 Q3UQ73 Q8BM16 Q91VD9 uc007bfu.1 uc007bfu.2 uc007bfu.3 uc007bfu.4 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:27799543, PubMed:32072193). Essential for catalysing the entry and efficient transfer of electrons within complex I (PubMed:27799543). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (PubMed:27799543). Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence=; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 1 [2Fe-2S] cluster per subunit. ; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 2 [4Fe-4S] clusters per subunit. ; Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is the largest subunit of complex I and it is a component of the iron- sulfur (IP) fragment of the enzyme (By similarity). Complex I associates with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (PubMed:27799543). In astrocytes, less complex I is assembled into supercomplexes as compared to neurons (PubMed:27799543). Interacts with MDM2 (By similarity). Interacts with AKAP1 (PubMed:32072193). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Brain. More abundant in neurons than in astrocytes (at protein level). Acetylation of Lys-84 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the complex I 75 kDa subunit family. NADH dehydrogenase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial intermembrane space NADH dehydrogenase (ubiquinone) activity apoptotic mitochondrial changes electron carrier activity membrane oxidoreductase activity oxidoreductase activity, acting on NAD(P)H ATP synthesis coupled electron transport myelin sheath cellular respiration ATP metabolic process metal ion binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding 4 iron, 4 sulfur cluster binding regulation of mitochondrial membrane potential oxidation-reduction process respiratory chain reactive oxygen species metabolic process uc007bfu.1 uc007bfu.2 uc007bfu.3 uc007bfu.4 
ENSMUST00000027114.6 Maip1 ENSMUST00000027114.6 matrix AAA peptidase interacting protein 1 (from RefSeq NM_001081181.3) ENSMUST00000027114.1 ENSMUST00000027114.2 ENSMUST00000027114.3 ENSMUST00000027114.4 ENSMUST00000027114.5 MAIP1_MOUSE Maip1 NM_001081181 Q8BHE8 Q8R3N9 uc007bbc.1 uc007bbc.2 uc007bbc.3 uc007bbc.4 Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). Interacts with AFG3L2 (PubMed:27642048). Interacts with SPG7 (By similarity). Interacts with SMDT1/EMRE (via the N-terminal transit peptide); interaction is direct and takes place before maturation of SMDT1/EMRE (By similarity). Mitochondrion matrix Sequence=AAH24945.1; Type=Erroneous initiation; Evidence=; mitochondrion mitochondrial inner membrane mitochondrial matrix inner mitochondrial membrane organization protein insertion into mitochondrial membrane from inner side mitochondrial calcium uptake protein insertion into mitochondrial membrane mitochondrial calcium ion homeostasis uc007bbc.1 uc007bbc.2 uc007bbc.3 uc007bbc.4 
ENSMUST00000027121.15 Rftn2 ENSMUST00000027121.15 raftlin family member 2, transcript variant 1 (from RefSeq NM_028713.1) ENSMUST00000027121.1 ENSMUST00000027121.10 ENSMUST00000027121.11 ENSMUST00000027121.12 ENSMUST00000027121.13 ENSMUST00000027121.14 ENSMUST00000027121.2 ENSMUST00000027121.3 ENSMUST00000027121.4 ENSMUST00000027121.5 ENSMUST00000027121.6 ENSMUST00000027121.7 ENSMUST00000027121.8 ENSMUST00000027121.9 NM_028713 Q8CHX7 Q8R306 Q9CXJ5 RFTN2_MOUSE uc007bag.1 uc007bag.2 uc007bag.3 Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195). May regulate B-cell antigen receptor-mediated signaling. Cell membrane ; Lipid-anchor Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CHX7-1; Sequence=Displayed; Name=2; IsoId=Q8CHX7-2; Sequence=VSP_015324, VSP_015325; Expressed in B-cells, heart, brain, spleen, large intestine and lung (PubMed:19414744). Expressed in dendritic cells and macrophages (PubMed:27022195). Double RFTN1 and RFTN2 mutant mice show no visible phenotype under pathogen-free conditions but show greatly reduced interferon beta production in splenic dendritic cells under poly(I:C) or lipopolysaccharide stimulation. Belongs to the raftlin family. molecular_function plasma membrane membrane dsRNA transport response to exogenous dsRNA uc007bag.1 uc007bag.2 uc007bag.3 
ENSMUST00000027123.15 Hspd1 ENSMUST00000027123.15 heat shock protein 1 (chaperonin), transcript variant 1 (from RefSeq NM_010477.4) CH60_MOUSE ENSMUST00000027123.1 ENSMUST00000027123.10 ENSMUST00000027123.11 ENSMUST00000027123.12 ENSMUST00000027123.13 ENSMUST00000027123.14 ENSMUST00000027123.2 ENSMUST00000027123.3 ENSMUST00000027123.4 ENSMUST00000027123.5 ENSMUST00000027123.6 ENSMUST00000027123.7 ENSMUST00000027123.8 ENSMUST00000027123.9 Hsp60 NM_010477 P19226 P19227 P63038 P97602 Q3KQP2 Q3UIP0 Q8C2C7 Q8VEF4 uc007bab.1 uc007bab.2 uc007bab.3 uc007bab.4 Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. Reaction=ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.; EC=5.6.1.7; Evidence=; Homoheptamer arranged in a ring structure. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. Interacts with 2 heptameric Hsp10 rings to form the symmetrical football complex (By similarity). Interacts with HRAS (PubMed:1347942). Interacts with ATAD3A. Interacts with ETFBKMT and EEF1AKMT3 (By similarity). Interacts with MFHAS1 (By similarity). Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P63038-1; Sequence=Displayed; Name=2; IsoId=P63038-2; Sequence=VSP_025020; Belongs to the chaperonin (HSP60) family. Sequence=AAI06113.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence.; Evidence=; nucleotide binding lipopolysaccharide binding response to hypoxia protease binding p53 binding B cell cytokine production MyD88-dependent toll-like receptor signaling pathway positive regulation of T cell mediated immune response to tumor cell response to ischemia double-stranded RNA binding ATP binding extracellular space cytoplasm mitochondrion mitochondrial inner membrane mitochondrial matrix early endosome peroxisomal matrix rough endoplasmic reticulum Golgi apparatus cytosol plasma membrane clathrin-coated pit protein folding 'de novo' protein folding activation of cysteine-type endopeptidase activity involved in apoptotic process response to unfolded protein high-density lipoprotein particle binding apoptotic mitochondrial changes response to heat response to cold cell surface response to organic substance response to organic cyclic compound response to activity membrane isomerase activity enzyme binding mitochondrial crista coated vesicle secretory granule ubiquitin protein ligase binding response to lipopolysaccharide positive regulation of interferon-alpha production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-6 production macromolecular complex response to ATP apolipoprotein binding apolipoprotein A-I binding cellular response to heat protein refolding B cell proliferation T cell activation B cell activation response to cocaine response to drug response to hydrogen peroxide zymogen granule positive regulation of macrophage activation positive regulation of apoptotic process negative regulation of apoptotic process myelin sheath intracellular membrane-bounded organelle negative regulation of neuron apoptotic process insulin binding response to estrogen macromolecular complex binding protein import into mitochondrial intermembrane space membrane raft lipopolysaccharide receptor complex protein heterodimerization activity isotype switching to IgG isotypes positive regulation of inflammatory response protein stabilization positive regulation of T cell activation unfolded protein binding chaperone binding response to glucocorticoid interaction with symbiont extracellular exosome negative regulation of apoptotic process in bone marrow cellular response to interleukin-7 negative regulation of reactive oxygen species biosynthetic process positive regulation of tumor necrosis factor secretion positive regulation of interleukin-6 secretion adhesion of symbiont to host uc007bab.1 uc007bab.2 uc007bab.3 uc007bab.4 
ENSMUST00000027125.7 Coq10b ENSMUST00000027125.7 coenzyme Q10B, transcript variant 1 (from RefSeq NM_001039710.1) A0A0R4J066 A0A0R4J066_MOUSE Coq10b ENSMUST00000027125.1 ENSMUST00000027125.2 ENSMUST00000027125.3 ENSMUST00000027125.4 ENSMUST00000027125.5 ENSMUST00000027125.6 NM_001039710 uc007azz.1 uc007azz.2 Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. Interacts with coenzyme Q. Belongs to the COQ10 family. uc007azz.1 uc007azz.2 
ENSMUST00000027127.14 Sf3b1 ENSMUST00000027127.14 splicing factor 3b, subunit 1 (from RefSeq NM_031179.2) ENSMUST00000027127.1 ENSMUST00000027127.10 ENSMUST00000027127.11 ENSMUST00000027127.12 ENSMUST00000027127.13 ENSMUST00000027127.2 ENSMUST00000027127.3 ENSMUST00000027127.4 ENSMUST00000027127.5 ENSMUST00000027127.6 ENSMUST00000027127.7 ENSMUST00000027127.8 ENSMUST00000027127.9 G5E866 G5E866_MOUSE NM_031179 Sf3b1 uc007azx.1 uc007azx.2 uc007azx.3 uc007azx.4 uc007azx.5 Nucleus Belongs to the SF3B1 family. spliceosomal complex assembly mRNA splicing, via spliceosome mRNA binding nucleus U2 snRNP U12-type spliceosomal complex nuclear speck U11/U12 snRNP U2-type precatalytic spliceosome catalytic step 2 spliceosome uc007azx.1 uc007azx.2 uc007azx.3 uc007azx.4 uc007azx.5 
ENSMUST00000027131.6 Slc39a10 ENSMUST00000027131.6 solute carrier family 39 (zinc transporter), member 10, transcript variant 1 (from RefSeq NM_172653.3) ENSMUST00000027131.1 ENSMUST00000027131.2 ENSMUST00000027131.3 ENSMUST00000027131.4 ENSMUST00000027131.5 Kiaa1265 NM_172653 Q6P5F6 Q80TG2 Q8BX42 Q8C0L2 S39AA_MOUSE Slc39a10 Zip10 uc007axc.1 uc007axc.2 uc007axc.3 Zinc-influx transporter. When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT). mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (By similarity). Plays an important for both mature B-cell maintenance and humoral immune responses (PubMed:25074919). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (PubMed:28098160). Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29353; Evidence=; Interacts with SLC39A6 (PubMed:27274087). This interaction triggers cells to undergo EMT and mitosis (By similarity). Found in a complex with SLC39A6, SLC39A10 and with the 'Ser-727' phosphorylated form of STAT3 throughout mitosis (By similarity). Found in a complex with SLC39A6, SLC39A10 and with NCAM1; this complex controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-tomesenchymal transition (PubMed:28098160). Found in a complex with SLC39A6, SLC39A10 and with GSK3B that controls NCAM1 phosphorylation (PubMed:28098160). Cell membrane ulti-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Note=Expressed at the apical membranes of proximal tubules in the kidney. Expressed in the liver, kidney and brain. Greatly increased in liver and brain, in response to Zn(2+) deficiency (at protein level). Undergoes N-terminal ectodomain shedding. Belongs to the ZIP transporter (TC 2.A.5) family. Sequence=AAH59214.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC33542.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of B cell apoptotic process zinc ion transmembrane transporter activity plasma membrane integral component of plasma membrane ion transport zinc II ion transport cellular zinc ion homeostasis membrane integral component of membrane metal ion transport positive regulation of B cell proliferation metal ion transmembrane transporter activity positive regulation of B cell receptor signaling pathway transmembrane transport zinc II ion transmembrane import positive regulation of protein tyrosine phosphatase activity uc007axc.1 uc007axc.2 uc007axc.3 
ENSMUST00000027137.11 Slc40a1 ENSMUST00000027137.11 solute carrier family 40 (iron-regulated transporter), member 1 (from RefSeq NM_016917.2) ENSMUST00000027137.1 ENSMUST00000027137.10 ENSMUST00000027137.2 ENSMUST00000027137.3 ENSMUST00000027137.4 ENSMUST00000027137.5 ENSMUST00000027137.6 ENSMUST00000027137.7 ENSMUST00000027137.8 ENSMUST00000027137.9 Fpn1 Ireg1 NM_016917 Q3UHZ9 Q8BME5 Q8BUM5 Q9JHI9 Q9JIM9 Q9JKP4 S40A1_MOUSE Slc11a3 Slc39a1 uc007awu.1 uc007awu.2 uc007awu.3 Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:16054062, PubMed:30213870). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (PubMed:16054062, PubMed:30213870). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (By similarity). Reaction=Fe(2+)(in) = Fe(2+)(out); Xref=Rhea:RHEA:28486, ChEBI:CHEBI:29033; Evidence= During elevated serum iron levels, liver-derived hepcidin/HAMP negatively regulates cell surface ferroportin/SLC40A1 by inducing its ubiquitination, internalization, and degradation. Indeed, hepcidin/HAMP affinity towards ferroportin/SLC40A1 increases by 80-fold in the presence of iron. Identified in a complex with STOM. Interacts with HAMP; this interaction promotes SLC40A1 rapid ubiquitination. Q9JHI9; P12023: App; NbExp=2; IntAct=EBI-2931424, EBI-78814; Q9JHI9; Q9JHI9: Slc40a1; NbExp=2; IntAct=EBI-2931424, EBI-2931424; Q9JHI9; O60674: JAK2; Xeno; NbExp=3; IntAct=EBI-2931424, EBI-518647; Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Note=Localized to the basolateral membrane of polarized epithelial cells. High expression in spleen, liver, kidney, heart and duodenum. Polyubiquitinated by RNF217; leading to proteasomal degradation (PubMed:33895792). Ubiquitination is necessary for its internalization by hepcidin/HAMP (By similarity). Deficient mice exhibit embryonic lethality. These mice cannot transfer iron from the extraembryonic visceral endoderm into the embryo proper, leading to a defect in embryonic growth and consequent death (PubMed:16054062). Erythroid-specific deletion reduces serum iron but increased tissue iron contents (PubMed:30213870). Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. Manganese (Mn) transport by SLC40A1 remains controversial. Some in vitro studies have suggested that SLC40A1 transports minimal amounts of Mn(2+) (By similarity). Other groups have suggested that it does not (By similarity). The predicted apparent affinity of SLC40A1 for manganese is extremely low compared with iron, implying that any SLC40A1-mediated Mn transport in vivo would likely be trivial (By similarity). A recent study examined the role of SLC40A1 in Mn homeostasis by using Tmprss6-O mice, which express high levels of hepcidin/HAMP and therefore have very low SLC40A1 levels in their tissues. These mice show frank iron deficiency and reduced iron levels in most tissues, but manganese levels are largely unaffected (PubMed:30888356). These studies suggest that manganese is propably not the physiological substrate of SLC40A1. lymphocyte homeostasis endothelium development iron ion transmembrane transporter activity protein binding nucleoplasm cytosol plasma membrane ion transport iron ion transport cellular iron ion homeostasis synaptic vesicle ferrous iron transmembrane transporter activity membrane integral component of membrane basolateral plasma membrane peptide hormone binding regulation of transcription from RNA polymerase II promoter in response to iron iron ion transmembrane transport identical protein binding negative regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter spleen development iron ion homeostasis spleen trabecula formation multicellular organismal iron ion homeostasis divalent inorganic cation transport ferrous iron export uc007awu.1 uc007awu.2 uc007awu.3 
ENSMUST00000027139.15 Wdr75 ENSMUST00000027139.15 WD repeat domain 75 (from RefSeq NM_028599.3) ENSMUST00000027139.1 ENSMUST00000027139.10 ENSMUST00000027139.11 ENSMUST00000027139.12 ENSMUST00000027139.13 ENSMUST00000027139.14 ENSMUST00000027139.2 ENSMUST00000027139.3 ENSMUST00000027139.4 ENSMUST00000027139.5 ENSMUST00000027139.6 ENSMUST00000027139.7 ENSMUST00000027139.8 ENSMUST00000027139.9 NM_028599 Q08EC1 Q3U821 Utp17 WDR75_MOUSE uc007awt.1 uc007awt.2 uc007awt.3 Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome. SSU processome is composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus nucleus nucleolus rRNA processing ribosome biogenesis positive regulation of transcription from RNA polymerase I promoter positive regulation of rRNA processing uc007awt.1 uc007awt.2 uc007awt.3 
ENSMUST00000027144.8 Cps1 ENSMUST00000027144.8 carbamoyl-phosphate synthetase 1 (from RefSeq NM_001080809.2) A0JNU4 CPSM_MOUSE ENSMUST00000027144.1 ENSMUST00000027144.2 ENSMUST00000027144.3 ENSMUST00000027144.4 ENSMUST00000027144.5 ENSMUST00000027144.6 ENSMUST00000027144.7 NM_001080809 Q6NX75 Q8C196 uc007biy.1 uc007biy.2 uc007biy.3 uc007biy.4 This gene encodes a protein localized to the inner mitochondrial matrix. The encoded protein plays a role in the detoxification of ammonia by catalyzing the first step in the urea cycle in which carbomyl-phosphate is synthesized from ammonia and bicarbonate. Carbamoyl-phosphate is subsequently converted to urea that is excreted by the kidneys. Deficiency of the encoded enzyme leads to an accumulation of ammonia in the blood. High levels of ammonia are toxic to the central nervous system and result in neurological disorders. [provided by RefSeq, Oct 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC126969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. Reaction=2 ATP + hydrogencarbonate + NH4(+) = 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate; Xref=Rhea:RHEA:18029, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=6.3.4.16; Evidence=; Requires N-acetyl-L-glutamate (NAG) as an allosteric activator. Can form homooligomers (monomers as predominant form and dimers). (Microbial infection) Interacts with P.berghei (ANKA strain) phospholipid scramblase PLSCR; the interaction is involved in the interaction between parasite sporozoites and host hepatocytes. Q8C196; Q8K2C6: Sirt5; NbExp=2; IntAct=EBI-2348828, EBI-2348809; Mitochondrion Nucleus, nucleolus Cell membrane ; Peripheral membrane protein ; Extracellular side Note=Localizes to the cell surface of hepatocytes. Expressed in hepatocytes (at protein level). The type-1 glutamine amidotransferase domain is defective. Undergoes proteolytic cleavage in the C-terminal region corresponding to the loss of approximately 12 AA residues from the C- terminus. Acetylation of Lys-287, Lys-603, Lys-841 and Lys-1291 is observed in liver mitochondria from fasted mice but not from fed mice. Succinylated at Lys-44, Lys-287 and Lys-1291. Desuccinylated at Lys-1291 by SIRT5, leading to activation. Glutarylated. Glutarylation levels increase during fasting. Deglutarylated by SIRT5 at Lys-55, Lys-219, Lys-412, Lys-889, Lys-892, Lys-915, Lys-1360 and Lys-1486, leading to activation. Was initially reported to be deacetylated by Sirt5 (PubMed:19410549). However, it was later shown that Sirt5 has poor deacetylase activity and mediates desuccinylation of Cps1 instead (PubMed:22076378). urea cycle nucleotide binding liver development catalytic activity carbamoyl-phosphate synthase (ammonia) activity carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity endopeptidase activity calcium ion binding protein binding ATP binding phospholipid binding nucleus nucleolus cytoplasm mitochondrion mitochondrial inner membrane 'de novo' pyrimidine nucleobase biosynthetic process proteolysis glutamine metabolic process nitrogen compound metabolic process midgut development metabolic process response to toxic substance response to zinc ion response to amine glutamate binding ligase activity triglyceride catabolic process response to food response to lipopolysaccharide macromolecular complex response to glucagon response to oleic acid vasodilation response to drug response to starvation mitochondrial nucleoid response to amino acid cellular response to fibroblast growth factor stimulus macromolecular complex binding nitric oxide metabolic process metal ion binding response to steroid hormone homocysteine metabolic process response to glucocorticoid response to cAMP anion homeostasis response to growth hormone hepatocyte differentiation carbamoyl phosphate biosynthetic process cellular response to cAMP cellular response to glucagon stimulus cellular response to oleic acid response to dexamethasone modified amino acid binding cellular response to ammonia uc007biy.1 uc007biy.2 uc007biy.3 uc007biy.4 
ENSMUST00000027146.9 Ikzf2 ENSMUST00000027146.9 IKAROS family zinc finger 2, transcript variant 2 (from RefSeq NM_011770.5) ENSMUST00000027146.1 ENSMUST00000027146.2 ENSMUST00000027146.3 ENSMUST00000027146.4 ENSMUST00000027146.5 ENSMUST00000027146.6 ENSMUST00000027146.7 ENSMUST00000027146.8 Helios IKZF2_MOUSE NM_011770 P81183 Q8C8A3 Zfpn1a2 Znfn1a2 uc007bjd.1 uc007bjd.2 uc007bjd.3 uc007bjd.4 uc007bjd.5 Associates with Ikaros at centromeric heterochromatin. Interacts with IKZF4 and IKZF5. Nucleus. Event=Alternative splicing; Named isoforms=2; Name=B; IsoId=P81183-1; Sequence=Displayed; Name=A; IsoId=P81183-2; Sequence=VSP_006846; Restricted to the T-cell lineage. Abundant in thymus, low expression in bone marrow and brain and no detectable expression in spleen, liver, kidney or muscle. Belongs to the Ikaros C2H2-type zinc-finger protein family. nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm protein homodimerization activity transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding protein heterodimerization activity uc007bjd.1 uc007bjd.2 uc007bjd.3 uc007bjd.4 uc007bjd.5 
ENSMUST00000027153.6 Acadl ENSMUST00000027153.6 acyl-Coenzyme A dehydrogenase, long-chain (from RefSeq NM_007381.4) A0A0R4J083 A0A0R4J083_MOUSE Acadl ENSMUST00000027153.1 ENSMUST00000027153.2 ENSMUST00000027153.3 ENSMUST00000027153.4 ENSMUST00000027153.5 NM_007381 uc007bir.1 uc007bir.2 uc007bir.3 uc007bir.4 This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C12- and C16-acylCoA. In mice, deficiency of this gene can cause sudden death, cardiomyopathy as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. The transit peptide annotated at aa 1-30 is inferred by similarity to the cleavage site in the orthologous rat protein as described in PMID: 2777793. The software program TargetP1.1 predicts that the transit peptide in mouse is aa 1-27. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK151845.1, AK167537.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Reaction=(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:47448, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:84650, ChEBI:CHEBI:87701; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47449; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-octadecadienoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:47300, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57387, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:77553; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47301; Evidence=; Reaction=H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:43448, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57379, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:61526; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43449; Evidence=; Reaction=H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:43464, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:62077, ChEBI:CHEBI:62620; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43465; Evidence=; Reaction=H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47240, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57394, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:71412; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47241; Evidence=; Reaction=H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:48180, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57386, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:62242; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48181; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:47232, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:65052, ChEBI:CHEBI:74693; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47233; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:47316, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57385, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:61405; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47317; Evidence=; Reaction=a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:17721, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:83721, ChEBI:CHEBI:83727; EC=1.3.8.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17722; Evidence=; Reaction=decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:48176, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:61406, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48177; Evidence=; Reaction=docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47228, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:65059, ChEBI:CHEBI:74692; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47229; Evidence=; Reaction=dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47296, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57330, ChEBI:CHEBI:57375, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47297; Evidence=; Reaction=eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47236, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57380, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:74691; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47237; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Lipid metabolism; mitochondrial fatty acid beta-oxidation. Homotetramer. Mitochondrion matrix Belongs to the acyl-CoA dehydrogenase family. fatty-acyl-CoA binding acyl-CoA dehydrogenase activity long-chain-acyl-CoA dehydrogenase activity mitochondrion mitochondrial matrix oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors mitochondrial membrane fatty acid beta-oxidation using acyl-CoA dehydrogenase long-chain fatty acid catabolic process flavin adenine dinucleotide binding protein homotetramerization oxidation-reduction process uc007bir.1 uc007bir.2 uc007bir.3 uc007bir.4 
ENSMUST00000027157.10 Rpe ENSMUST00000027157.10 ribulose-5-phosphate-3-epimerase, transcript variant 2 (from RefSeq NM_025683.3) ENSMUST00000027157.1 ENSMUST00000027157.2 ENSMUST00000027157.3 ENSMUST00000027157.4 ENSMUST00000027157.5 ENSMUST00000027157.6 ENSMUST00000027157.7 ENSMUST00000027157.8 ENSMUST00000027157.9 NM_025683 Q8C130 Q8VEE0 Q9BSB5 Q9CQZ3 RPE_MOUSE uc007bil.1 uc007bil.2 uc007bil.3 Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate. Reaction=D-ribulose 5-phosphate = D-xylulose 5-phosphate; Xref=Rhea:RHEA:13677, ChEBI:CHEBI:57737, ChEBI:CHEBI:58121; EC=5.1.3.1; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Note=Binds 1 divalent metal cation per subunit. Active with Fe(2+), and probably also with Mn(2+), Zn(2+) and Co(2+). ; Carbohydrate degradation. Homodimer. Belongs to the ribulose-phosphate 3-epimerase family. Sequence=BAC26287.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; Sequence=BAC26287.1; Type=Miscellaneous discrepancy; Evidence=; catalytic activity ribulose-phosphate 3-epimerase activity cytosol carbohydrate metabolic process pentose-phosphate shunt pentose-phosphate shunt, non-oxidative branch isomerase activity racemase and epimerase activity, acting on carbohydrates and derivatives pentose catabolic process carbohydrate binding identical protein binding protein homodimerization activity intracellular membrane-bounded organelle cellular carbohydrate metabolic process metal ion binding monosaccharide binding uc007bil.1 uc007bil.2 uc007bil.3 
ENSMUST00000027164.9 Ctla4 ENSMUST00000027164.9 cytotoxic T-lymphocyte-associated protein 4, transcript variant 1 (from RefSeq NM_009843.4) CH29-120A16.2-001 Ctla4 ENSMUST00000027164.1 ENSMUST00000027164.2 ENSMUST00000027164.3 ENSMUST00000027164.4 ENSMUST00000027164.5 ENSMUST00000027164.6 ENSMUST00000027164.7 ENSMUST00000027164.8 NM_009843 Q6GTR6 Q6GTR6_MOUSE uc007bez.1 uc007bez.2 uc007bez.3 This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]. Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Golgi apparatus integral component of plasma membrane immune response cellular response to DNA damage stimulus external side of plasma membrane membrane integral component of membrane negative regulation of B cell proliferation regulation of T cell proliferation negative regulation of T cell proliferation positive regulation of apoptotic process clathrin-coated endocytic vesicle negative regulation of regulatory T cell differentiation perinuclear region of cytoplasm negative regulation of immune response B cell receptor signaling pathway protein complex involved in cell adhesion uc007bez.1 uc007bez.2 uc007bez.3 
ENSMUST00000027165.3 Cd28 ENSMUST00000027165.3 CD28 antigen (from RefSeq NM_007642.4) CD28_MOUSE ENSMUST00000027165.1 ENSMUST00000027165.2 NM_007642 P31041 Q6GSH7 uc007bew.1 uc007bew.2 uc007bew.3 uc007bew.4 Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Interacts with GRB2 (By similarity). Membrane; Single-pass type I membrane protein. immunological synapse protease binding immune system process positive regulation of inflammatory response to antigenic stimulus SH3/SH2 adaptor activity plasma membrane immune response external side of plasma membrane cell surface positive regulation of gene expression negative regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane protein kinase binding T cell costimulation positive regulation of interleukin-10 production positive regulation of interleukin-4 production positive regulation of T cell proliferation T cell activation regulation of T cell proliferation protein homodimerization activity negative thymic T cell selection regulatory T cell differentiation positive regulation of interleukin-2 biosynthetic process membrane raft regulation of regulatory T cell differentiation positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter positive regulation of alpha-beta T cell proliferation positive regulation of isotype switching to IgG isotypes T cell receptor signaling pathway positive regulation of protein kinase B signaling apoptotic signaling pathway protein complex involved in cell adhesion uc007bew.1 uc007bew.2 uc007bew.3 uc007bew.4 
ENSMUST00000027173.15 Wdr12 ENSMUST00000027173.15 WD repeat domain 12, transcript variant 2 (from RefSeq NM_021312.5) ENSMUST00000027173.1 ENSMUST00000027173.10 ENSMUST00000027173.11 ENSMUST00000027173.12 ENSMUST00000027173.13 ENSMUST00000027173.14 ENSMUST00000027173.2 ENSMUST00000027173.3 ENSMUST00000027173.4 ENSMUST00000027173.5 ENSMUST00000027173.6 ENSMUST00000027173.7 ENSMUST00000027173.8 ENSMUST00000027173.9 MNCb-5414 NM_021312 Q9CST3 Q9JJA4 Q9JKF5 WDR12_MOUSE uc007bee.1 uc007bee.2 uc007bee.3 uc007bee.4 Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome. Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain). Nucleus, nucleolus cleus, nucleoplasm Belongs to the WD repeat WDR12/YTM1 family. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) protein binding nucleus nucleoplasm nucleolus rRNA processing Notch signaling pathway cell proliferation preribosome, large subunit precursor ribosome biogenesis ribosomal large subunit biogenesis ribonucleoprotein complex binding PeBoW complex uc007bee.1 uc007bee.2 uc007bee.3 uc007bee.4 
ENSMUST00000027178.13 Als2 ENSMUST00000027178.13 alsin Rho guanine nucleotide exchange factor, transcript variant 1 (from RefSeq NM_028717.6) ALS2_MOUSE ENSMUST00000027178.1 ENSMUST00000027178.10 ENSMUST00000027178.11 ENSMUST00000027178.12 ENSMUST00000027178.2 ENSMUST00000027178.3 ENSMUST00000027178.4 ENSMUST00000027178.5 ENSMUST00000027178.6 ENSMUST00000027178.7 ENSMUST00000027178.8 ENSMUST00000027178.9 G5E868 NM_028717 Q8JZR1 Q920R0 Q9CXJ3 uc007bdm.1 uc007bdm.2 uc007bdm.3 uc007bdm.4 May act as a GTPase regulator. Controls survival and growth of spinal motoneurons. Forms a heteromeric complex with ALS2CL. Interacts with ALS2CL (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q920R0-1; Sequence=Displayed; Name=2 ; IsoId=Q920R0-2; Sequence=VSP_050525, VSP_050526; behavioral fear response in utero embryonic development ruffle receptor recycling guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity protein binding nucleus cytoplasm early endosome centrosome cytosol response to oxidative stress endosome organization lysosomal transport axonogenesis neuromuscular junction development locomotory behavior protein localization cell death postsynaptic density membrane vesicle organization endosomal transport Rac protein signal transduction Rab guanyl-nucleotide exchange factor activity Rab GTPase binding lamellipodium axon dendrite growth cone Rac guanyl-nucleotide exchange factor activity vesicle macromolecular complex regulation of Rho protein signal transduction synaptic transmission, glutamatergic identical protein binding protein homodimerization activity neuron projection neuronal cell body regulation of GTPase activity dendritic spine intracellular membrane-bounded organelle protein serine/threonine kinase activator activity positive regulation of GTPase activity positive regulation of protein kinase activity Rac GTPase binding neuron projection morphogenesis regulation of endosome size protein homooligomerization positive regulation of protein serine/threonine kinase activity uc007bdm.1 uc007bdm.2 uc007bdm.3 uc007bdm.4 
ENSMUST00000027185.11 Stradb ENSMUST00000027185.11 STE20-related kinase adaptor beta, transcript variant 1 (from RefSeq NM_172656.6) Als2cr2 ENSMUST00000027185.1 ENSMUST00000027185.10 ENSMUST00000027185.2 ENSMUST00000027185.3 ENSMUST00000027185.4 ENSMUST00000027185.5 ENSMUST00000027185.6 ENSMUST00000027185.7 ENSMUST00000027185.8 ENSMUST00000027185.9 NM_172656 Papk Q6P922 Q8BU86 Q8BXK0 Q8K4T2 Q8K4T3 STRAB_MOUSE Syradb uc007bcy.1 uc007bcy.2 uc007bcy.3 uc007bcy.4 Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2 (By similarity). Nucleus. Cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PAPK-A; IsoId=Q8K4T3-1; Sequence=Displayed; Name=2; Synonyms=PAPK-B; IsoId=Q8K4T3-2; Sequence=VSP_016626, VSP_016627; The protein kinase domain is predicted to be catalytically inactive. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ser-184 is present instead of the conserved Asp which is expected to be an active site residue. nucleotide binding cell morphogenesis protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm cytosol protein phosphorylation protein export from nucleus cytoskeleton organization cell cycle JNK cascade aggresome signal transduction by protein phosphorylation activation of protein kinase activity negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc007bcy.1 uc007bcy.2 uc007bcy.3 uc007bcy.4 
ENSMUST00000027186.12 Trak2 ENSMUST00000027186.12 trafficking protein, kinesin binding 2 (from RefSeq NM_172406.3) Als2cr3 ENSMUST00000027186.1 ENSMUST00000027186.10 ENSMUST00000027186.11 ENSMUST00000027186.2 ENSMUST00000027186.3 ENSMUST00000027186.4 ENSMUST00000027186.5 ENSMUST00000027186.6 ENSMUST00000027186.7 ENSMUST00000027186.8 ENSMUST00000027186.9 NM_172406 Q6P9N8 Q6P9N8_MOUSE Trak2 uc007bcv.1 uc007bcv.2 uc007bcv.3 uc007bcv.4 Mitochondrion Belongs to the milton family. receptor binding nucleus cytoplasm mitochondrion early endosome plasma membrane regulation of transcription from RNA polymerase II promoter protein O-linked glycosylation protein targeting anterograde axonal transport protein localization endosome to lysosome transport myosin binding kinesin binding enzyme binding neurogenesis dendrite TPR domain binding cytoplasmic vesicle dendrite cytoplasm neuron projection neuronal cell body axonal growth cone vesicle transport along microtubule mitochondrion distribution dendrite morphogenesis negative regulation of axonogenesis GABA receptor binding dendritic transport of mitochondrion anterograde axonal transport of mitochondrion anterograde dendritic transport of mitochondrion axon cytoplasm uc007bcv.1 uc007bcv.2 uc007bcv.3 uc007bcv.4 
ENSMUST00000027189.15 Casp8 ENSMUST00000027189.15 caspase 8, transcript variant 1 (from RefSeq NM_009812.3) Casp8 ENSMUST00000027189.1 ENSMUST00000027189.10 ENSMUST00000027189.11 ENSMUST00000027189.12 ENSMUST00000027189.13 ENSMUST00000027189.14 ENSMUST00000027189.2 ENSMUST00000027189.3 ENSMUST00000027189.4 ENSMUST00000027189.5 ENSMUST00000027189.6 ENSMUST00000027189.7 ENSMUST00000027189.8 ENSMUST00000027189.9 NM_009812 Q3U607 Q3U607_MOUSE uc007bcs.1 uc007bcs.2 This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]. Belongs to the peptidase C14A family. cysteine-type endopeptidase activity proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity regulation of apoptotic process uc007bcs.1 uc007bcs.2 
ENSMUST00000027193.9 Ndufb3 ENSMUST00000027193.9 NADH:ubiquinone oxidoreductase subunit B3 (from RefSeq NM_025597.3) ENSMUST00000027193.1 ENSMUST00000027193.2 ENSMUST00000027193.3 ENSMUST00000027193.4 ENSMUST00000027193.5 ENSMUST00000027193.6 ENSMUST00000027193.7 ENSMUST00000027193.8 NDUB3_MOUSE NM_025597 Q3UUR9 Q9CQZ6 uc007bck.1 uc007bck.2 uc007bck.3 uc007bck.4 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side Methylation at His residues by METTL9 enhances complex I-mediated mitochondrial respiration. Belongs to the complex I NDUFB3 subunit family. molecular_function mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I membrane integral component of membrane electron transport chain mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc007bck.1 uc007bck.2 uc007bck.3 uc007bck.4 
ENSMUST00000027198.12 Orc2 ENSMUST00000027198.12 origin recognition complex, subunit 2, transcript variant 1 (from RefSeq NM_008765.4) ENSMUST00000027198.1 ENSMUST00000027198.10 ENSMUST00000027198.11 ENSMUST00000027198.2 ENSMUST00000027198.3 ENSMUST00000027198.4 ENSMUST00000027198.5 ENSMUST00000027198.6 ENSMUST00000027198.7 ENSMUST00000027198.8 ENSMUST00000027198.9 NM_008765 ORC2_MOUSE Orc2l Q60862 uc007bcd.1 uc007bcd.2 uc007bcd.3 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity). Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Interacts with DBF4 (PubMed:12614612). Interacts with MCM10. Interacts with LRWD1 throughout the cell cycle; this interaction, wich occurs only with non-ubiquitinated form of LRWD1, prevents LRWD1 ubiquitination and hence stabilizes the protein. Interacts with POLQ (By similarity). Nucleus. Belongs to the ORC2 family. nuclear chromosome, telomeric region chromatin heterochromatin origin recognition complex condensed chromosome inner kinetochore DNA replication origin binding nucleus nucleoplasm nuclear origin of replication recognition complex centrosome DNA replication uc007bcd.1 uc007bcd.2 uc007bcd.3 
ENSMUST00000027202.9 Sgo2a ENSMUST00000027202.9 shugoshin 2A, transcript variant 1 (from RefSeq NM_199007.2) ENSMUST00000027202.1 ENSMUST00000027202.2 ENSMUST00000027202.3 ENSMUST00000027202.4 ENSMUST00000027202.5 ENSMUST00000027202.6 ENSMUST00000027202.7 ENSMUST00000027202.8 NM_199007 Q7TSY8 Q811I4 Q8C9C4 Q8CGJ4 Q9CS55 SGO2_MOUSE Sgo2 Sgol2 Sgol2a uc007bbk.1 uc007bbk.2 uc007bbk.3 uc007bbk.4 Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. Interacts with PPP2CA. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with CDCA8 (By similarity). Q7TSY8; Q9Z1B5: Mad2l1; NbExp=3; IntAct=EBI-2552468, EBI-2552918; Nucleus Chromosome, centromere romosome, centromere, kinetochore Note=Centromeric localization requires the presence of BUB1 and AUKRB (By similarity). During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (PubMed:17205076) (PubMed:18084284). SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (PubMed:17205076). During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (PubMed:17205076). Ubiquitously expressed in proliferating cells. Highly expressed in the testis and oocytes. Mice develop normally and survive to adulthood without any apparent alteration. However, both males and females are infertile. This defect appears cytologically as complete loss of centromere cohesion at metaphase II, leading to single chromatids, and physiologically as formation of aneuploid gametes that gave rise to infertility. Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin). Belongs to the shugoshin family. Sequence=AAH23855.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed chromosome, centromeric region condensed nuclear chromosome, centromeric region protein binding nucleus nucleoplasm chromosome cell cycle chromosome segregation male meiosis female meiotic division protein localization meiotic sister chromatid cohesion involved in meiosis I nuclear body mitotic cohesin complex cell division meiotic cell cycle meiotic sister chromatid cohesion, centromeric positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric uc007bbk.1 uc007bbk.2 uc007bbk.3 uc007bbk.4 
ENSMUST00000027214.4 Ercc5 ENSMUST00000027214.4 excision repair cross-complementing rodent repair deficiency, complementation group 5 (from RefSeq NM_011729.3) E9QM61 E9QM61_MOUSE ENSMUST00000027214.1 ENSMUST00000027214.2 ENSMUST00000027214.3 Ercc5 NM_011729 uc007awi.1 uc007awi.2 uc007awi.3 uc007awi.4 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Nucleus Belongs to the XPG/RAD2 endonuclease family. XPG subfamily. DNA binding single-stranded DNA binding catalytic activity nuclease activity endonuclease activity nucleus DNA repair nucleotide-excision repair hydrolase activity, acting on ester bonds nucleic acid phosphodiester bond hydrolysis uc007awi.1 uc007awi.2 uc007awi.3 uc007awi.4 
ENSMUST00000027217.9 Ecrg4 ENSMUST00000027217.9 ECRG4 augurin precursor (from RefSeq NM_024283.3) AUGN_MOUSE ENSMUST00000027217.1 ENSMUST00000027217.2 ENSMUST00000027217.3 ENSMUST00000027217.4 ENSMUST00000027217.5 ENSMUST00000027217.6 ENSMUST00000027217.7 ENSMUST00000027217.8 Ecrg4 NM_024283 Q99LS0 Q9D2U7 uc007avp.1 uc007avp.2 uc007avp.3 uc007avp.4 Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (PubMed:20404145). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (PubMed:20404145). Secreted toplasm Apical cell membrane Expressed in the intermediate lobe of pituitary, glomerular layer of adrenal cortex, choroid plexus and atrioventricular node of the heart (PubMed:17284679). Expressed in the brain with high expression in the choroid plexus and the epithelial lining of the central canal and expression in the gray matter of the spinal cord (at protein level) (PubMed:21349154). At embryonic stage 14.5 dpc, primarily expressed in the choroid plexus, and low expression in the heart and cartilage (at protein level) (PubMed:21349154). At 18.5 dpc, expressed in adrenal cortex, choroid plexus and bone (PubMed:17284679). Low expression in the brain of young, 2-month-old animals, except for the mitral cell layer of the olfactory bulb (PubMed:20404145). Strongly expressed in the brains of aged, 15- to 21-month-old mice with expression in the subgranular zone of the dentate gyrus and in the corpus callosum (at protein level) (PubMed:20404145). Also expressed in the CA1-3 regions of the hippocampus, as well as in the cerebellum, brainstem and cortex (PubMed:20404145). In vitro, up-regulated in senescent cells, including embryonic fibroblasts and oligodendrocyte precursor cells (PubMed:20404145). Belongs to the augurin family. neuropeptide hormone activity extracellular region extracellular space cytoplasm plasma membrane neuropeptide signaling pathway central nervous system development negative regulation of cell proliferation response to wounding membrane apical plasma membrane vasopressin secretion dense core granule anaphase-promoting complex-dependent catabolic process regulation of cell proliferation positive regulation of corticotropin secretion positive regulation of corticotropin-releasing hormone secretion G1 to G0 transition cellular senescence positive regulation of corticosterone secretion uc007avp.1 uc007avp.2 uc007avp.3 uc007avp.4 
ENSMUST00000027226.12 Khdrbs2 ENSMUST00000027226.12 KH domain containing, RNA binding, signal transduction associated 2 (from RefSeq NM_133235.3) ENSMUST00000027226.1 ENSMUST00000027226.10 ENSMUST00000027226.11 ENSMUST00000027226.2 ENSMUST00000027226.3 ENSMUST00000027226.4 ENSMUST00000027226.5 ENSMUST00000027226.6 ENSMUST00000027226.7 ENSMUST00000027226.8 ENSMUST00000027226.9 KHDR2_MOUSE NM_133235 Q6NXZ3 Q9WU01 Slm1 uc007anp.1 uc007anp.2 uc007anp.3 The protein encoded by this gene is similar to the src associated in mitosis, 68 kDa protein, which is an RNA-binding protein and a substrate for Src-family tyrosine kinases during mitosis. This protein has a KH RNA-binding motif and proline-rich motifs which may be SH2 and SH3 domain binding sites. A similar rat protein is an RNA-binding protein which is tyrosine phosphorylated by Src during mitosis. These studies also suggest that the rat protein may function as an adaptor protein for Src by binding the SH2 and SH3 domains of various other proteins. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK078160.1, SRR7345562.1931936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion (By similarity). Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Induces an increased concentration-dependent incorporation of exon in CD44 pre- mRNA by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4 (PubMed:22196734, PubMed:24469635). Its phosphorylation by FYN inhibits its ability to regulate splice site selection (By similarity). May function as an adapter protein for Src kinases during mitosis (PubMed:10077576). Self-associates to form homooligomers (By similarity). Interacts with KHDRBS1/SAM68; heterooligomer formation of KHDRBS family proteins may modulate RNA substrate specificity (PubMed:10077576). Interacts with RBMX, SAFB, SFRS9 and YTHDC1 (By similarity). Interacts with FYN and PLCG1 (via SH3 domain). Interacts (phosphorylated) with FYN, GRB2, PLCG1 and RASA1 (via SH2 domain) (PubMed:10077576). Q9WU01; P39688: Fyn; NbExp=2; IntAct=EBI-8339046, EBI-524514; Q9WU01; P10686: Plcg1; Xeno; NbExp=2; IntAct=EBI-8339046, EBI-520788; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WU01-1; Sequence=Displayed; Name=2; IsoId=Q9WU01-2; Sequence=VSP_029065, VSP_029066; Expressed in heart, skin, brain, colon, spleen, kidney, cervix and testis. In adult cerebellum expressed predominantly in Purkinje cells and in the hippocampus is abundantly expressed in glutamatergic dentate granule cells and in specific inhibitory Schaffer collateral-associated and path-associated interneurons; expression is restricted to neuronal subpopulations largely non-overlapping with expression of KHDRBS3/SLM-2 (at protein level). In the developing cerebellum expression is increasing in the first 3 postnatal weeks. Methylated. Tyrosine phosphorylated by FYN, PTK6 and SRC. Tyrosine phosphorylated by SRC during mitosis. Belongs to the KHDRBS family. Sequence=AAH66814.1; Type=Erroneous initiation; Evidence=; nucleic acid binding RNA binding SH3/SH2 adaptor activity protein binding nucleus mRNA processing poly(A) binding poly(U) RNA binding positive regulation of signal transduction SH3 domain binding SH2 domain binding identical protein binding regulation of mRNA splicing, via spliceosome uc007anp.1 uc007anp.2 uc007anp.3 
ENSMUST00000027230.3 Dnaaf6rt ENSMUST00000027230.3 dynein axonemal assembly factor 6, retrotransposed (from RefSeq NM_029062.2) DAAF6_MOUSE Dnaaf6 ENSMUST00000027230.1 ENSMUST00000027230.2 NM_029062 Pih1d3 Q3KNI6 uc007anm.1 uc007anm.2 uc007anm.3 Plays a role in cytoplasmic pre-assembly of axonemal dynein. Interacts with HSPA1A/B, HSP90AA1 and DNAI2 (PubMed:24421334). Interacts with DNAAF2 and DNAAF4 (By similarity). Cytoplasm Golgi apparatus, trans-Golgi network Note=Localized to the cytoplasm of spermatogenic cells. Specifically expressed in testis. Detected in pachytene spermatocytes from 5 weeks of age and in pachytene and diplotene spermatocytes of adult mice. Not detected in spermatids or mature sperm. Deficient mice develop normally but manifest male sterility. Sperm are immotile and fragile with the axoneme of the flagellum lacking outer dynein arms (ODAs) and inner dynein arms (IDAs) and showing a disturbed microtubules organization. Belongs to the PIH1 family. cilium movement protein binding cytoplasm flagellated sperm motility chaperone binding axonemal dynein complex assembly uc007anm.1 uc007anm.2 uc007anm.3 
ENSMUST00000027231.13 Slc9a2 ENSMUST00000027231.13 solute carrier family 9 (sodium/hydrogen exchanger), member 2 (from RefSeq NM_001033289.2) ENSMUST00000027231.1 ENSMUST00000027231.10 ENSMUST00000027231.11 ENSMUST00000027231.12 ENSMUST00000027231.2 ENSMUST00000027231.3 ENSMUST00000027231.4 ENSMUST00000027231.5 ENSMUST00000027231.6 ENSMUST00000027231.7 ENSMUST00000027231.8 ENSMUST00000027231.9 NM_001033289 Nhe2 Q3ZAS0 SL9A2_MOUSE uc007aun.1 uc007aun.2 uc007aun.3 Plasma membrane Na(+)/H(+) antiporter (PubMed:14962844, PubMed:16690903). Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:14962844). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt (PubMed:14962844, PubMed:16690903). Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (PubMed:34985202, PubMed:14962844). Reaction=H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out); Xref=Rhea:RHEA:29419, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101; Evidence=; In colonic crypts activated by low pHi, hyperosmolarity, and an increase in intracellular cAMP levels. Interacts with CHP1 and CHP2. Apical cell membrane ; Multi-pass membrane protein Expressed in the colonic epithelium predominantly in the cryptal region. Maximally expressed in the luminal membrane near the crypt base and in the middle of the crypt (at protein level) (PubMed:14962844). Expressed in gastric epithelium (at protein level) (PubMed:21900251). SLC9A2 null mice do not develop diarrhea, have no changes in quantitated intestinal Na(+) absorption, however mice develop a sharp reduction in the number of gastric parietal and zymogenic cells associated with a loss of net acid secretion in adult but not in juvenile mice (PubMed:9502765, PubMed:11099134). SLC9A2 null mice also exhibited reduced recovery from laser-induced ulceration of the stomach (PubMed:21900251). Double-knockout of SLC9A2 and SLC9A3 are not significantly different than the SLC9A3-deficient alone in diarrhea, intestinal Na(+) absorption, or reduced life expectancy (PubMed:11705743). Steady-state pH intracellular is significantly altered along the colonic crypt axis in deficicent mice (PubMed:34985202). Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. plasma membrane brush border ion transport cation transport sodium ion transport regulation of pH protein localization antiporter activity solute:proton antiporter activity sodium:proton antiporter activity potassium:proton antiporter activity membrane integral component of membrane regulation of intracellular pH transmembrane transport potassium ion transmembrane transport anion transmembrane transport sodium ion import across plasma membrane hydrogen ion transmembrane transport uc007aun.1 uc007aun.2 uc007aun.3 
ENSMUST00000027232.15 Ptp4a1 ENSMUST00000027232.15 protein tyrosine phosphatase 4a1, transcript variant 1 (from RefSeq NM_011200.3) ENSMUST00000027232.1 ENSMUST00000027232.10 ENSMUST00000027232.11 ENSMUST00000027232.12 ENSMUST00000027232.13 ENSMUST00000027232.14 ENSMUST00000027232.2 ENSMUST00000027232.3 ENSMUST00000027232.4 ENSMUST00000027232.5 ENSMUST00000027232.6 ENSMUST00000027232.7 ENSMUST00000027232.8 ENSMUST00000027232.9 NM_011200 O09097 O09154 Prl1 Q3UFU9 Q63739 TP4A1_MOUSE uc007anh.1 uc007anh.2 Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Inhibited by sodium orthovanadate and pentamidine. Homotrimer. Interacts with tubulin (By similarity). Interacts with ATF5. Cell membrane ; Lipid-anchor Early endosome Endoplasmic reticulum Cytoplasm Cytoplasm, cytoskeleton, spindle Nucleus Note=And mitotic spindle. Expressed in all tissues except heart and skeletal muscle, from 10.5 dpc to 18.5 dpc. Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus. Belongs to the protein-tyrosine phosphatase family. phosphoprotein phosphatase activity protein tyrosine phosphatase activity prenylated protein tyrosine phosphatase activity nucleus cytoplasm endosome early endosome endoplasmic reticulum spindle cytoskeleton plasma membrane protein dephosphorylation cell cycle multicellular organism development protein tyrosine/serine/threonine phosphatase activity cytoplasmic side of plasma membrane membrane dephosphorylation hydrolase activity phosphatase activity positive regulation of cell migration peptidyl-tyrosine dephosphorylation uc007anh.1 uc007anh.2 
ENSMUST00000027233.9 Slc9a4 ENSMUST00000027233.9 solute carrier family 9 (sodium/hydrogen exchanger), member 4 (from RefSeq NM_177084.4) ENSMUST00000027233.1 ENSMUST00000027233.2 ENSMUST00000027233.3 ENSMUST00000027233.4 ENSMUST00000027233.5 ENSMUST00000027233.6 ENSMUST00000027233.7 ENSMUST00000027233.8 NM_177084 Nhe4 Q3TCU9 Q8BUE1 Q9WUJ6 SL9A4_MOUSE uc007aul.1 uc007aul.2 uc007aul.3 Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (PubMed:15684419, PubMed:20484819). As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (PubMed:20484819). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (PubMed:15684419). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (PubMed:32372285). Reaction=H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out); Xref=Rhea:RHEA:29419, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29421; Evidence=; Reaction=Na(+)(out) + NH4(+)(in) = Na(+)(in) + NH4(+)(out); Xref=Rhea:RHEA:76431, ChEBI:CHEBI:28938, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76432; Evidence=; Up-regulated in response to high extracellular sodium concentration. Homodimer; each protomer has one site for sodium and one site for proton binding (By similarity). Interacts with CHP1 and CHP2 (By similarity). Basolateral cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Zymogen granule membrane ; Multi-pass membrane protein Note=Enrichment at apical or basolateral membrane may be tissue-dependent. Expressed in kidney. Expressed in uterus and endometrial epithelial cells. Expressed in the inner segments of inner medullary collecting ducts (IMCD) in kidney. Expressed in AGTR1- positive neurons in organum vasculosum of the lamina terminalis (at protein level). Up-regulated upon metabolic acidosis. May be phosphorylated. Mice are born at the expected Mendelian rate. They display lack of renal adaptation to metabolic acidosis marked by impaired medullary ammonia accumulation and inability to increase urinary net acid excretion to recover from acidosis. They show major morphological changes in the gastric mucosa associated with decreased numbers of gastric parietal cells and hypochlorhydria. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors. gastric acid secretion epithelial cell development plasma membrane ion transport cation transport sodium ion transport regulation of pH antiporter activity solute:proton antiporter activity sodium:proton antiporter activity potassium:proton antiporter activity membrane integral component of membrane basolateral plasma membrane apical plasma membrane regulation of intracellular pH transmembrane transport potassium ion transmembrane transport anion transmembrane transport sodium ion import across plasma membrane hydrogen ion transmembrane transport uc007aul.1 uc007aul.2 uc007aul.3 
ENSMUST00000027237.12 Il18rap ENSMUST00000027237.12 interleukin 18 receptor accessory protein (from RefSeq NM_010553.5) ENSMUST00000027237.1 ENSMUST00000027237.10 ENSMUST00000027237.11 ENSMUST00000027237.2 ENSMUST00000027237.3 ENSMUST00000027237.4 ENSMUST00000027237.5 ENSMUST00000027237.6 ENSMUST00000027237.7 ENSMUST00000027237.8 ENSMUST00000027237.9 I18RA_MOUSE Il18rap NM_010553 Q9Z2B1 uc007auk.1 uc007auk.2 uc007auk.3 Interleukin-18 (or interferon-gamma inducing factor) is a proinflammatory cytokine that induces cell-mediated immunity following microbial infection. This gene encodes a member of the interleukin-1 receptor family. The encoded protein is an accessory subunit of the receptor for interleukin-18 and mediates signaling through this cytokine. Mice lacking this gene exhibit a defective cell-mediated immune response. [provided by RefSeq, Jan 2014]. Sequence Note: Removed 9 bases from the 5' end that did not align to the reference genome assembly. ##Evidence-Data-START## Transcript exon combination :: AF077347.1, BC120600.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Within the IL18 receptor complex, does not mediate IL18- binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:11046021, PubMed:15843532, PubMed:9792649). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity). Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302; Evidence=; Forms a ternary complex with IL18 and IL18R1. Within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation. Cell membrane ; Single-pass type I membrane protein The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. Impaired IL-18 signaling. Belongs to the interleukin-1 receptor family. interleukin-1 receptor activity plasma membrane inflammatory response signal transduction cell proliferation membrane integral component of membrane interferon-gamma production interleukin-6 production interleukin-18-mediated signaling pathway T-helper 1 cell cytokine production interleukin-18 receptor activity neutrophil activation interleukin-18 receptor complex positive regulation of natural killer cell mediated cytotoxicity positive regulation of NF-kappaB transcription factor activity cellular response to hydrogen peroxide cellular response to cytokine stimulus cellular response to interleukin-18 uc007auk.1 uc007auk.2 uc007auk.3 
ENSMUST00000027241.11 Il1r1 ENSMUST00000027241.11 interleukin 1 receptor, type I, transcript variant 1 (from RefSeq NM_008362.3) ENSMUST00000027241.1 ENSMUST00000027241.10 ENSMUST00000027241.2 ENSMUST00000027241.3 ENSMUST00000027241.4 ENSMUST00000027241.5 ENSMUST00000027241.6 ENSMUST00000027241.7 ENSMUST00000027241.8 ENSMUST00000027241.9 Il1r1 NM_008362 Q32MH0 Q32MH0_MOUSE uc007atv.1 uc007atv.2 uc007atv.3 Belongs to the interleukin-1 receptor family. interleukin-1 receptor activity interleukin-1, Type I, activating receptor activity platelet-derived growth factor receptor binding signal transduction membrane integral component of membrane positive regulation of interferon-gamma production interleukin-1-mediated signaling pathway response to interleukin-1 positive regulation of T-helper 1 cell cytokine production uc007atv.1 uc007atv.2 uc007atv.3 
ENSMUST00000027243.13 Il1r2 ENSMUST00000027243.13 interleukin 1 receptor, type II, transcript variant 2 (from RefSeq NM_010555.5) ENSMUST00000027243.1 ENSMUST00000027243.10 ENSMUST00000027243.11 ENSMUST00000027243.12 ENSMUST00000027243.2 ENSMUST00000027243.3 ENSMUST00000027243.4 ENSMUST00000027243.5 ENSMUST00000027243.6 ENSMUST00000027243.7 ENSMUST00000027243.8 ENSMUST00000027243.9 Il1r2 NM_010555 Q4FK69 Q4FK69_MOUSE uc007atu.1 uc007atu.2 uc007atu.3 uc007atu.4 uc007atu.5 interleukin-1 receptor activity interleukin-1, Type II, blocking receptor activity membrane integral component of membrane cytokine-mediated signaling pathway uc007atu.1 uc007atu.2 uc007atu.3 uc007atu.4 uc007atu.5 
ENSMUST00000027247.11 Pdcl3 ENSMUST00000027247.11 phosducin-like 3 (from RefSeq NM_026850.4) ENSMUST00000027247.1 ENSMUST00000027247.10 ENSMUST00000027247.2 ENSMUST00000027247.3 ENSMUST00000027247.4 ENSMUST00000027247.5 ENSMUST00000027247.6 ENSMUST00000027247.7 ENSMUST00000027247.8 ENSMUST00000027247.9 NM_026850 PDCL3_MOUSE Q3TH06 Q8BVF2 Q99JX2 Q9D0W3 Viaf1 uc007atc.1 uc007atc.2 uc007atc.3 Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity). Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain) (By similarity). Forms ternary complexes with the chaperonin CCT complex and actin substrate, leading to inhibition of actin folding (By similarity). Interacts with XIAP (via BIR 3 and RING domain) (By similarity). Interacts with HSP90AA1 and HSP90AB1 (PubMed:27496612). Cytoplasm Cytoplasm, perinuclear region Endoplasmic reticulum Expressed in blood vessels (at protein level). By hypoxia and heat shock. N-terminal methionine acetylation destabilizes the protein. Belongs to the phosducin family. angiogenesis positive regulation of endothelial cell proliferation nucleus cytoplasm endoplasmic reticulum cytosol protein folding apoptotic process positive regulation of gene expression actin cytoskeleton organization macromolecular complex cellular response to heat vascular endothelial growth factor receptor 2 binding protein binding involved in protein folding positive regulation of angiogenesis regulation of peptidyl-tyrosine phosphorylation protein stabilization chaperone-mediated protein folding perinucleolar compartment negative regulation of chaperone-mediated protein folding negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc007atc.1 uc007atc.2 uc007atc.3 
ENSMUST00000027251.12 Rev1 ENSMUST00000027251.12 REV1, DNA directed polymerase, transcript variant 1 (from RefSeq NM_019570.4) ENSMUST00000027251.1 ENSMUST00000027251.10 ENSMUST00000027251.11 ENSMUST00000027251.2 ENSMUST00000027251.3 ENSMUST00000027251.4 ENSMUST00000027251.5 ENSMUST00000027251.6 ENSMUST00000027251.7 ENSMUST00000027251.8 ENSMUST00000027251.9 NM_019570 Q920Q2 Q9QXV2 REV1_MOUSE Rev1l uc007asr.1 uc007asr.2 Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Interacts with FAAP20 (By similarity). Monomer. Interacts with the DNA polymerase zeta which is composed of REV3L and MAD2L2; the interaction with MAD2L2 is direct and requires that REV3L is in its closed conformation. Interacts with POLH, POLI and POLK. Q920Q2; Q6NZ36-1: FAAP20; Xeno; NbExp=7; IntAct=EBI-2114764, EBI-15965017; Nucleus Ubiquitous. The C-terminal domain is necessary for protein interactions. Belongs to the DNA polymerase type-Y family. DNA binding damaged DNA binding DNA-directed DNA polymerase activity protein binding nucleus DNA repair cellular response to DNA damage stimulus response to UV transferase activity nucleotidyltransferase activity deoxycytidyl transferase activity error-prone translesion synthesis metal ion binding error-free translesion synthesis DNA biosynthetic process uc007asr.1 uc007asr.2 
ENSMUST00000027252.8 Eif5b ENSMUST00000027252.8 eukaryotic translation initiation factor 5B (from RefSeq NM_198303.2) ENSMUST00000027252.1 ENSMUST00000027252.2 ENSMUST00000027252.3 ENSMUST00000027252.4 ENSMUST00000027252.5 ENSMUST00000027252.6 ENSMUST00000027252.7 IF2P_MOUSE If2 NM_198303 Q05D44 Q3SYI4 Q3TQJ8 Q3UL37 Q3UM39 Q6PAI0 Q8CFF4 Q8CGD6 uc007aso.1 uc007aso.2 Plays a role in translation initiation. Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after formation of the 80S initiation complex. Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation- competent ribosomes. In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Name=a monovalent cation; Xref=ChEBI:CHEBI:60242; Evidence=; Note=Binds 1 monovalent cation per monomer in the active site. Structural cofactor that stabilizes the GTP-bound 'on' state. May also act as a transition state stabilizer of the hydrolysis reaction. ; Interacts through its C-terminal domain (CTD) with the CTD of eIF1A (EIF1AX) or with the CTD of EIF5 (mutually exclusive) through a common binding site. Interacts with eIF1A (EIF1AX) from the location of the start codon by the 43S complex until the formation of the 80S complex (By similarity). Interacts with ANXA5 in a calcium and phospholipid-dependent manner (By similarity). Cytoplasm Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. Sequence=AAH18347.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH37150.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH40746.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH60288.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; nucleotide binding translation initiation factor activity GTPase activity GTP binding cytoplasm translation translational initiation regulation of translational initiation hydrolase activity metal ion binding uc007aso.1 uc007aso.2 
ENSMUST00000027256.12 Mrpl30 ENSMUST00000027256.12 mitochondrial ribosomal protein L30, transcript variant 1 (from RefSeq NM_027098.3) ENSMUST00000027256.1 ENSMUST00000027256.10 ENSMUST00000027256.11 ENSMUST00000027256.2 ENSMUST00000027256.3 ENSMUST00000027256.4 ENSMUST00000027256.5 ENSMUST00000027256.6 ENSMUST00000027256.7 ENSMUST00000027256.8 ENSMUST00000027256.9 NM_027098 Q99KJ7 Q9D7N6 RM30_MOUSE uc007asj.1 uc007asj.2 uc007asj.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uL30 family. molecular_function structural constituent of ribosome mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit ribosome translation biological_process large ribosomal subunit uc007asj.1 uc007asj.2 uc007asj.3 
ENSMUST00000027263.14 Stk17b ENSMUST00000027263.14 serine/threonine kinase 17b (apoptosis-inducing) (from RefSeq NM_133810.3) Drak2 ENSMUST00000027263.1 ENSMUST00000027263.10 ENSMUST00000027263.11 ENSMUST00000027263.12 ENSMUST00000027263.13 ENSMUST00000027263.2 ENSMUST00000027263.3 ENSMUST00000027263.4 ENSMUST00000027263.5 ENSMUST00000027263.6 ENSMUST00000027263.7 ENSMUST00000027263.8 ENSMUST00000027263.9 NM_133810 Q3TNG7 Q8BG48 Q8BLV9 Q923E7 ST17B_MOUSE uc007azj.1 uc007azj.2 uc007azj.3 uc007azj.4 Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus. Nucleus Cell membrane Endoplasmic reticulum-Golgi intermediate compartment Note=Colocalizes with STK17B at the plasma membrane. Autophosphorylated. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus endoplasmic reticulum-Golgi intermediate compartment plasma membrane protein phosphorylation apoptotic process programmed cell death actin cytoskeleton membrane kinase activity phosphorylation transferase activity intracellular signal transduction protein autophosphorylation positive regulation of fibroblast apoptotic process uc007azj.1 uc007azj.2 uc007azj.3 uc007azj.4 
ENSMUST00000027264.10 Asnsd1 ENSMUST00000027264.10 asparagine synthetase domain containing 1, transcript variant 1 (from RefSeq NM_133728.3) ASND1_MOUSE ENSMUST00000027264.1 ENSMUST00000027264.2 ENSMUST00000027264.3 ENSMUST00000027264.4 ENSMUST00000027264.5 ENSMUST00000027264.6 ENSMUST00000027264.7 ENSMUST00000027264.8 ENSMUST00000027264.9 NM_133728 Q3THX2 Q3U2Y8 Q3U317 Q8BFS9 Q8BM66 Q91YY3 uc007azg.1 uc007azg.2 uc007azg.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BFS9-1; Sequence=Displayed; Name=2; IsoId=Q8BFS9-2; Sequence=VSP_032353; Sequence=BAC28818.1; Type=Frameshift; Evidence=; Sequence=BAE33002.1; Type=Frameshift; Evidence=; asparagine synthase (glutamine-hydrolyzing) activity asparagine biosynthetic process glutamine metabolic process cellular amino acid biosynthetic process uc007azg.1 uc007azg.2 uc007azg.3 
ENSMUST00000027265.10 Osgepl1 ENSMUST00000027265.10 O-sialoglycoprotein endopeptidase-like 1, transcript variant 1 (from RefSeq NM_001285839.1) ENSMUST00000027265.1 ENSMUST00000027265.2 ENSMUST00000027265.3 ENSMUST00000027265.4 ENSMUST00000027265.5 ENSMUST00000027265.6 ENSMUST00000027265.7 ENSMUST00000027265.8 ENSMUST00000027265.9 NM_001285839 OSGL1_MOUSE Osgepl1 Q3UVG1 Q6PEB4 Q8BLB6 Q9D0N0 uc007azb.1 uc007azb.2 uc007azb.3 uc007azb.4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. Reaction=adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA; Xref=Rhea:RHEA:37059, Rhea:RHEA-COMP:10162, Rhea:RHEA-COMP:10163, ChEBI:CHEBI:15378, ChEBI:CHEBI:73682, ChEBI:CHEBI:74411, ChEBI:CHEBI:74418, ChEBI:CHEBI:456215; EC=2.3.1.234; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 1 divalent metal cation per subunit. Monomer. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PEB4-1; Sequence=Displayed; Name=2; IsoId=Q6PEB4-2; Sequence=VSP_028831, VSP_028832; Belongs to the KAE1 / TsaD family. EKC/KEOPS complex tRNA threonylcarbamoyladenosine modification metalloendopeptidase activity mitochondrion proteolysis tRNA processing transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups metal ion binding N(6)-L-threonylcarbamoyladenine synthase uc007azb.1 uc007azb.2 uc007azb.3 uc007azb.4 
ENSMUST00000027266.4 Ormdl1 ENSMUST00000027266.4 ORM1-like 1 (S. cerevisiae) (from RefSeq NM_145517.4) ENSMUST00000027266.1 ENSMUST00000027266.2 ENSMUST00000027266.3 NM_145517 ORML1_MOUSE Q8BK13 Q921I0 uc011wks.1 uc011wks.2 uc011wks.3 Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:31880535). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity). Ceramide-sensitive subunit of the serine palmitoyltransferase (SPT) complex, which is also composed of SPTLC1, SPTLC2/3 and SPTSSA/B. Endoplasmic reticulum membrane ; Multi-pass membrane protein Ceramides bind to ORMDL3 N-terminus and stabilize it in a conformation that physically restricts the accessibility of the substrates to their binding sites in the serine palmitoyltransferase (SPT) complex, hence inhibiting SPT catalytic activity. In the absence of ceramides, the N-terminus is flexible and permits substrate binding, thus liberating SPT from inhibition. No overt phenotype; due to the redundancy with other ORMDL proteins (PubMed:31880535). Simultaneous knockdown of ORMDL1 and ORMDL2 do not exhibit any visible phenotype; they remain fertile and show no sign of neurodegeneration (PubMed:31880535). Double knockdown of ORMDL1 and ORMDL3 show elevated brain levels of sphingolipids, compared with single ORMDL3 knockout and wild-type animals (PubMed:31880535). At 8 weeks of age, both male and female ORMDL1/3 double knockout mice weigh significantly less than wild-type mice and exhibit impaired myelination and motor-function abnormalities (PubMed:31880535). The triple knockout ORMDL1, ORMDL2 and ORMDL3 is not viable (PubMed:31880535). Belongs to the ORM family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane ceramide metabolic process membrane integral component of membrane SPOTS complex negative regulation of sphingolipid biosynthetic process cellular sphingolipid homeostasis negative regulation of ceramide biosynthetic process uc011wks.1 uc011wks.2 uc011wks.3 
ENSMUST00000027267.14 Pms1 ENSMUST00000027267.14 PMS1 homolog 1, mismatch repair system component (from RefSeq NM_153556.2) ENSMUST00000027267.1 ENSMUST00000027267.10 ENSMUST00000027267.11 ENSMUST00000027267.12 ENSMUST00000027267.13 ENSMUST00000027267.2 ENSMUST00000027267.3 ENSMUST00000027267.4 ENSMUST00000027267.5 ENSMUST00000027267.6 ENSMUST00000027267.7 ENSMUST00000027267.8 ENSMUST00000027267.9 NM_153556 Pms1 Q8K119 Q8K119_MOUSE uc007ayv.1 uc007ayv.2 uc007ayv.3 uc007ayv.4 uc007ayv.5 uc007ayv.6 Belongs to the DNA mismatch repair MutL/HexB family. DNA binding ATP binding nucleus mismatch repair ATPase activity enzyme binding mismatched DNA binding mismatch repair complex MutLalpha complex response to drug uc007ayv.1 uc007ayv.2 uc007ayv.3 uc007ayv.4 uc007ayv.5 uc007ayv.6 
ENSMUST00000027269.7 Mstn ENSMUST00000027269.7 myostatin (from RefSeq NM_010834.3) ENSMUST00000027269.1 ENSMUST00000027269.2 ENSMUST00000027269.3 ENSMUST00000027269.4 ENSMUST00000027269.5 ENSMUST00000027269.6 Gdf8 MSTN Mstn NM_010834 Q540E2 Q540E2_MOUSE uc007ayt.1 uc007ayt.2 uc007ayt.3 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Homozygous knockout mice for this gene exhibit increased muscle mass and bone density, and reduced adiposity. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK142222.1, AK132415.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Acts specifically as a negative regulator of skeletal muscle growth. Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3. Secreted Belongs to the TGF-beta family. receptor binding extracellular region extracellular space cytoplasm signal transduction growth factor activity response to heat response to gravity skeletal muscle atrophy negative regulation of muscle hypertrophy response to muscle activity ovulation cycle process response to testosterone identical protein binding skeletal muscle tissue regeneration response to estrogen response to ethanol negative regulation of myoblast differentiation positive regulation of transcription, DNA-templated muscle cell cellular homeostasis negative regulation of skeletal muscle tissue growth response to glucocorticoid response to electrical stimulus negative regulation of protein kinase B signaling negative regulation of skeletal muscle satellite cell proliferation negative regulation of satellite cell differentiation negative regulation of myoblast proliferation uc007ayt.1 uc007ayt.2 uc007ayt.3 
ENSMUST00000027271.9 Inpp1 ENSMUST00000027271.9 inositol polyphosphate-1-phosphatase (from RefSeq NM_008384.2) ENSMUST00000027271.1 ENSMUST00000027271.2 ENSMUST00000027271.3 ENSMUST00000027271.4 ENSMUST00000027271.5 ENSMUST00000027271.6 ENSMUST00000027271.7 ENSMUST00000027271.8 INPP_MOUSE Inpp1 NM_008384 P49442 Q8R3L1 uc007ayo.1 uc007ayo.2 uc007ayo.3 uc007ayo.4 uc007ayo.5 Mg(2+)-dependent phosphatase that catalyzes the hydrolysis of the 1-position phosphate from inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate and participates in inositol phosphate metabolism. Reaction=1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4- phosphate + phosphate; Xref=Rhea:RHEA:15553, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58282, ChEBI:CHEBI:58469; EC=3.1.3.57; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15554; Evidence=; Reaction=1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate; Xref=Rhea:RHEA:70319, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58414, ChEBI:CHEBI:83241; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70320; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by Li(+). Signal transduction; phosphatidylinositol signaling pathway. Monomer. Belongs to the inositol monophosphatase superfamily. inositol-1,4-bisphosphate 1-phosphatase activity hydrolase activity phosphatidylinositol phosphorylation inositol phosphate dephosphorylation metal ion binding uc007ayo.1 uc007ayo.2 uc007ayo.3 uc007ayo.4 uc007ayo.5 
ENSMUST00000027279.12 Nabp1 ENSMUST00000027279.12 nucleic acid binding protein 1, transcript variant 1 (from RefSeq NM_028696.3) ENSMUST00000027279.1 ENSMUST00000027279.10 ENSMUST00000027279.11 ENSMUST00000027279.2 ENSMUST00000027279.3 ENSMUST00000027279.4 ENSMUST00000027279.5 ENSMUST00000027279.6 ENSMUST00000027279.7 ENSMUST00000027279.8 ENSMUST00000027279.9 NM_028696 Obfc2a Q8BGW5 Q8C154 Q8C164 SOSB2_MOUSE Ssb2 uc007axn.1 uc007axn.2 Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM- dependent signaling pathways (By similarity). Component of the SOSS complex, composed of SOSS-B (SOSS- B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1 (By similarity). Nucleus Note=Localizes to nuclear foci following DNA damage. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGW5-1; Sequence=Displayed; Name=2; IsoId=Q8BGW5-2; Sequence=VSP_033603; Ubiquitous with high expression in the thymus. Belongs to the SOSS-B family. SOSS-B2 subfamily. double-strand break repair via homologous recombination nuclear chromosome, telomeric region DNA binding single-stranded DNA binding RNA binding nucleus nucleoplasm cytosol DNA repair cellular response to DNA damage stimulus mitotic cell cycle checkpoint response to ionizing radiation SOSS complex uc007axn.1 uc007axn.2 
ENSMUST00000027285.13 Unc50 ENSMUST00000027285.13 Involved in the cell surface expression of neuronal nicotinic receptors (By similarity). Binds RNA (By similarity). (from UniProt Q9CQ61) AK135885 ENSMUST00000027285.1 ENSMUST00000027285.10 ENSMUST00000027285.11 ENSMUST00000027285.12 ENSMUST00000027285.2 ENSMUST00000027285.3 ENSMUST00000027285.4 ENSMUST00000027285.5 ENSMUST00000027285.6 ENSMUST00000027285.7 ENSMUST00000027285.8 ENSMUST00000027285.9 Q9CQ61 UNC50_MOUSE uc007arp.1 uc007arp.2 uc007arp.3 Involved in the cell surface expression of neuronal nicotinic receptors (By similarity). Binds RNA (By similarity). Nucleus inner membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Highly expressed in periodontal ligament and bone marrow, but not in gingival fibroblasts. Belongs to the unc-50 family. Golgi membrane RNA binding nucleus nuclear inner membrane Golgi apparatus cell surface receptor signaling pathway protein transport membrane integral component of membrane integral component of Golgi membrane uc007arp.1 uc007arp.2 uc007arp.3 
ENSMUST00000027286.7 Coa5 ENSMUST00000027286.7 cytochrome C oxidase assembly factor 5 (from RefSeq NM_198006.4) COA5_MOUSE ENSMUST00000027286.1 ENSMUST00000027286.2 ENSMUST00000027286.3 ENSMUST00000027286.4 ENSMUST00000027286.5 ENSMUST00000027286.6 NM_198006 Q99M07 uc007aro.1 uc007aro.2 uc007aro.3 uc007aro.4 Involved in an early step of the mitochondrial complex IV assembly process. Belongs to the PET191 family. molecular_function mitochondrion mitochondrial respiratory chain complex IV assembly uc007aro.1 uc007aro.2 uc007aro.3 uc007aro.4 
ENSMUST00000027287.11 Inpp4a ENSMUST00000027287.11 inositol polyphosphate-4-phosphatase, type I, transcript variant 1 (from RefSeq NM_030266.4) ENSMUST00000027287.1 ENSMUST00000027287.10 ENSMUST00000027287.2 ENSMUST00000027287.3 ENSMUST00000027287.4 ENSMUST00000027287.5 ENSMUST00000027287.6 ENSMUST00000027287.7 ENSMUST00000027287.8 ENSMUST00000027287.9 F6V2U0 F6V2U0_MOUSE Inpp4a NM_030266 uc007arl.1 uc007arl.2 uc007arl.3 uc007arl.4 uc007arl.5 Signal transduction; phosphatidylinositol signaling pathway. Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity phosphatidylinositol-3-phosphate biosynthetic process uc007arl.1 uc007arl.2 uc007arl.3 uc007arl.4 uc007arl.5 
ENSMUST00000027291.7 Zap70 ENSMUST00000027291.7 zeta-chain (TCR) associated protein kinase, transcript variant 1 (from RefSeq NM_009539.4) ENSMUST00000027291.1 ENSMUST00000027291.2 ENSMUST00000027291.3 ENSMUST00000027291.4 ENSMUST00000027291.5 ENSMUST00000027291.6 NM_009539 P43404 P97455 Q80VV2 Q8CHJ3 Srk ZAP70_MOUSE Zap-70 uc007aqz.1 uc007aqz.2 uc007aqz.3 uc007aqz.4 This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lacking this gene are deficient in alpha-beta T lymphocytes in the thymus. In humans, mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T lymphocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B- lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T- cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Activated by phosphorylation at Tyr-492 in the activation loop. Interacts with CD247/CD3Z; this interaction docks ZAP70 at the stimulated TCR (By similarity). Interacts with NFAM1 (PubMed:15143214). Interacts with adapter protein SLA; this interaction negatively regulates T-cell receptor signaling (PubMed:10662792). Interacts with VAV1 (By similarity). Interacts with CBL; this interaction promotes ubiquitination, internalization and subsequent degradation of CD247/CD3Z (By similarity). Identified in a complex with CBL and UBE2L3 (By similarity). Interacts with SHB (By similarity). Interacts with adapter protein SLA2; this interaction negatively regulates T-cell receptor signaling (PubMed:11891219). Interacts with CBLB (PubMed:10646608). Interacts (via SH2 domains) with RHOH; this interaction regulates ZAP70 subcellular localization (PubMed:17028588). Interacts with DEF6 (PubMed:12648457). Interacts (ubiquitinated form) with OTUD7B and UBASH3B (PubMed:26903241). P43404; P24161: Cd247; NbExp=4; IntAct=EBI-3862932, EBI-7803400; Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In quiescent T-lymphocytes, ZAP70 is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P43404-1; Sequence=Displayed; Name=2; Synonyms=TZK; IsoId=P43404-2; Sequence=VSP_031159; Name=3; Synonyms=TZK-2; IsoId=P43404-3; Sequence=VSP_031160, VSP_031161; Isoform 1 and isoform 2 are expressed in thymus, spleen and lymph nodes. Isoform 2 is expressed in developing thymocytes from the CD44+CD25- stage up to mature T-cells. Isoform 1 is not expressed in thymocytes at the CD44+CD25- or CD44+CD25+ stages. Composed of 2 N-terminal SH2 domains and a C-terminal kinase domain. The tandem SH2 domains bind to the doubly phosphorylated tyrosine-based activation motif (ITAM) of CD247/CD3Z and the non- canonical phosphorylated tyrosine-based activation motif (TAM) of RHOH (By similarity). The interdomain B located between the second SH2 and the kinase domain has been implicated in binding to other signaling molecules including CBL or VAV1. Thus, ZAP70 can also function as a scaffold by recruiting additional factors to the stimulated TCR complex (By similarity). Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Phosphorylation of Tyr-314 and Tyr-314 are essential for ZAP70 positive function on T-lymphocyte activation whereas Tyr-290 has a negative regulatory role. Within the C-terminal kinase domain, Tyr-491 and Tyr-492 are phosphorylated after TCR induction, Tyr-491 playing a negative regulatory role and Tyr-492 a positive. Tyr-492 is dephosphorylated by PTN22. Ubiquitinated in response to T cell activation. Deubiquitinated by OTUD7B. Mice lack both CD4 and CD8 positive mature T- lymphocytes. Displays a complete block in B-Cell development at the pro-B cell stage in the absence of both SYK and ZAP70. Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. nucleotide binding immunological synapse phosphotyrosine binding adaptive immune response immune system process protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding cytoplasm cytosol plasma membrane cell-cell junction protein phosphorylation immune response membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation intracellular signal transduction T cell receptor complex beta selection positive thymic T cell selection negative thymic T cell selection thymic T cell selection membrane raft positive regulation of T cell differentiation positive regulation of alpha-beta T cell differentiation positive regulation of alpha-beta T cell proliferation protein autophosphorylation positive regulation of calcium-mediated signaling T cell receptor signaling pathway uc007aqz.1 uc007aqz.2 uc007aqz.3 uc007aqz.4 
ENSMUST00000027297.11 Plekhb2 ENSMUST00000027297.11 pleckstrin homology domain containing, family B (evectins) member 2, transcript variant 1 (from RefSeq NM_145516.2) ENSMUST00000027297.1 ENSMUST00000027297.10 ENSMUST00000027297.2 ENSMUST00000027297.3 ENSMUST00000027297.4 ENSMUST00000027297.5 ENSMUST00000027297.6 ENSMUST00000027297.7 ENSMUST00000027297.8 ENSMUST00000027297.9 Evt2 NM_145516 PKHB2_MOUSE Q3UDH6 Q8C4I4 Q8CA27 Q9QZC7 uc007apl.1 uc007apl.2 uc007apl.3 Involved in retrograde transport of recycling endosomes. Recycling endosome membrane ; Peripheral membrane protein. Note=Specifically detected in tubulovesicular structures, and colocalizes with TFNR. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9QZC7-1; Sequence=Displayed; Name=2; IsoId=Q9QZC7-2; Sequence=VSP_009786; Name=3; IsoId=Q9QZC7-3; Sequence=VSP_009785; Highly expressed in brain, retina, heart and kidney. Detected at lower levels in lung, muscle and nerve. Highly expressed at birth and up to day 3; expressed at lower levels in embryo and adult. The PH domain specifically binds phosphatidylserine, which is enriched in recycling endosome membranes, it doesn't recognize PIPs. phosphatidylinositol-3,4,5-trisphosphate binding endosome membrane integral component of membrane regulation of cell differentiation recycling endosome membrane uc007apl.1 uc007apl.2 uc007apl.3 
ENSMUST00000027298.5 Cfc1 ENSMUST00000027298.5 cryptic, EGF-CFC family member 1, transcript variant 2 (from RefSeq NR_153806.1) CFC1_MOUSE ENSMUST00000027298.1 ENSMUST00000027298.2 ENSMUST00000027298.3 ENSMUST00000027298.4 NR_153806 P97766 Q496U5 Q9JIB7 uc007aow.1 uc007aow.2 uc007aow.3 Nodal coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation. Cell membrane ; Lipid-anchor, GPI- anchor Secreted No expressed in adult tissues. Expressed during gastrulation (from 6.5 dpc to 11 dpc) in two spatial domains that correspond to the axial and lateral mesoderm. In the first domain expression is progressively localized to the anterior primitive streak, the head process, and the node and notochordal. In the second domain, expression is initially concentrated in the lateral region of the egg cylinder, and is later found circumferentially in the intermediate and lateral plate mesoderm. Furthermore, the expression can also be detected at the early head-fold stage in the midline neuroectoderm, and consequently is an early marker for the prospective floor plate of the neural tube. Expression ceases at the end of gastrulation, and has not been observed in later embryonic stages. N-glycosylated. Positional defects in internal organs. The lung presents a right pulmonary isomerism. The stomach is located on either the left or the right and the spleen is small and has an abnormal shape. The apex of the heart pointed to the right or left. In addition malpositioning of heart outflow tracts is observed, the aorta is connected to the right ventricle and emerged from the heart in a ventral position and to the right of the pulmonary artery. This one is connected to either the left or the right ventricle. Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. liver development heart looping heart morphogenesis receptor binding extracellular region plasma membrane multicellular organism development determination of left/right symmetry gastrulation endoderm development heart development post-embryonic development anterior/posterior pattern specification cell surface membrane BMP signaling pathway anchored component of membrane nodal signaling pathway nodal binding spleen development digestive tract morphogenesis anatomical structure development atrial septum morphogenesis left lung morphogenesis respiratory system development coronary vasculature development activin receptor binding uc007aow.1 uc007aow.2 uc007aow.3 
ENSMUST00000027299.10 Prss39 ENSMUST00000027299.10 serine protease 39, transcript variant 1 (from RefSeq NM_009355.3) ENSMUST00000027299.1 ENSMUST00000027299.2 ENSMUST00000027299.3 ENSMUST00000027299.4 ENSMUST00000027299.5 ENSMUST00000027299.6 ENSMUST00000027299.7 ENSMUST00000027299.8 ENSMUST00000027299.9 NM_009355 O70169 PRS39_MOUSE Q80YD5 Tesp1 uc007aov.1 uc007aov.2 uc007aov.3 May play an important role in the sperm/egg interaction; released during the acrosome reaction. Cytoplasmic vesicle, secretory vesicle, acrosome Secreted Expressed in testis. More specifically, abundantly expressed in the haploid round spermatid. There appears to be no human ortholog of this protein. Belongs to the peptidase S1 family. In contrast to other members of the family, lacks the conserved Asp at position 158, which is replaced by an Asn residue, suggesting it is inactive. acrosomal vesicle serine-type endopeptidase activity extracellular region extracellular space proteolysis cytoplasmic vesicle uc007aov.1 uc007aov.2 uc007aov.3 
ENSMUST00000027302.14 Ptpn18 ENSMUST00000027302.14 protein tyrosine phosphatase, non-receptor type 18, transcript variant 1 (from RefSeq NM_011206.2) ENSMUST00000027302.1 ENSMUST00000027302.10 ENSMUST00000027302.11 ENSMUST00000027302.12 ENSMUST00000027302.13 ENSMUST00000027302.2 ENSMUST00000027302.3 ENSMUST00000027302.4 ENSMUST00000027302.5 ENSMUST00000027302.6 ENSMUST00000027302.7 ENSMUST00000027302.8 ENSMUST00000027302.9 Flp1 NM_011206 PTN18_MOUSE Ptpk1 Q4JFH4 Q61152 Q62404 Q922E3 uc007aos.1 uc007aos.2 uc007aos.3 uc007aos.4 May be involved in growth and differentiation of hematopoietic cells. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Interacts with PSTPIP1. Q61152; P97814: Pstpip1; NbExp=3; IntAct=EBI-7074223, EBI-7484574; Q61152; Q99M15: Pstpip2; NbExp=7; IntAct=EBI-7074223, EBI-8653964; Nucleus Cytoplasm Highest expression in bone marrow. Also expressed in kidney, lung, ovary, spleen, thymus and lymph node. Expressed in the embryo from day 15.5. Belongs to the protein-tyrosine phosphatase family. Non- receptor class 4 subfamily. blastocyst formation phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity protein binding nucleus cytoplasm protein dephosphorylation dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc007aos.1 uc007aos.2 uc007aos.3 uc007aos.4 
ENSMUST00000027303.14 Imp4 ENSMUST00000027303.14 IMP4, U3 small nucleolar ribonucleoprotein, transcript variant 1 (from RefSeq NM_178601.4) D1Wsu40e ENSMUST00000027303.1 ENSMUST00000027303.10 ENSMUST00000027303.11 ENSMUST00000027303.12 ENSMUST00000027303.13 ENSMUST00000027303.2 ENSMUST00000027303.3 ENSMUST00000027303.4 ENSMUST00000027303.5 ENSMUST00000027303.6 ENSMUST00000027303.7 ENSMUST00000027303.8 ENSMUST00000027303.9 IMP4_MOUSE NM_178601 Q3U8H6 Q8CI42 Q8VHZ7 Q9CWN6 Q9CYT5 uc007aor.1 uc007aor.2 uc007aor.3 uc007aor.4 Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10. Nucleus, nucleolus Sequence=BAB26989.1; Type=Frameshift; Evidence=; fibrillar center nucleus nucleolus rRNA processing snoRNA binding preribosome small-subunit processome Mpp10 complex ribosome biogenesis uc007aor.1 uc007aor.2 uc007aor.3 uc007aor.4 
ENSMUST00000027312.11 Prim2 ENSMUST00000027312.11 DNA primase, p58 subunit, transcript variant 1 (from RefSeq NM_008922.3) ENSMUST00000027312.1 ENSMUST00000027312.10 ENSMUST00000027312.2 ENSMUST00000027312.3 ENSMUST00000027312.4 ENSMUST00000027312.5 ENSMUST00000027312.6 ENSMUST00000027312.7 ENSMUST00000027312.8 ENSMUST00000027312.9 NM_008922 P33610 PRI2_MOUSE Q3U4Z3 uc007anq.1 uc007anq.2 uc007anq.3 uc007anq.4 Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:8026492, PubMed:8253737). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:8253737). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di- nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:8253737). Binds RNA:DNA duplex and coordinates the catalytic activities of PRIM1 and POLA2 during primase- to-polymerase switch. Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Heterodimer of a catalytic subunit PRIM1 and a regulatory subunit PRIM2, also known as the DNA primase complex (PubMed:8026492, PubMed:8253737). Interacts via (C-terminus) with PRIM1 (By similarity). Component of the alpha DNA polymerase complex (also known as the alpha DNA polymerase-primase complex) consisting of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the primase complex subunits PRIM1 and PRIM2 respectively (PubMed:8253737). Within the complex, POLA1 directly interacts with PRIM2 (PubMed:8026492). The RNA:DNA duplex-binding domain interacts with the template phosphates at positions -2, -1, 1, and 2 positioning its bases -1, 1, and 2 for duplex formation. Interacts only with the beta- and gamma- phosphates of triphosphate moiety of initiating NTP of the primer. The side chain of His-303 mimics a RNA base that would be paired with the template nucleotide at position -1 via a hydrogen bond, thereby facilitating the stacking of the initiating NTP. In the initiating primosome a 'mini RNA:DNA' duplex is formed comprising three template nucleotides at positions -1, 1, and 2 on one strand and His-303, initiating NTP, and incoming NTP on the other strand. The interdomain linker provides flexibility in movement relative to primosome platform composed of PRIM1, the N-terminus of PRIM2, the C-terminus of POLA1 and POLA2. Together with POLA1 interdomain linker, allows for large-scale conformational changes of primosome and coordinated autoregulation of catalytic centers of PRIM1 and POLA1. It is proposed to move the C-terminus of PRIM2 close to PRIM1 during initiation, then move it away with the 5'-end of the nascent primer during elongation. The steric hindrance between the N- and C-terminus of PRIM2 as the RNA primer is elongated limits its length to 9 nucleotides. Ultimately a large rotation of the C-terminus of PRIM2 transfers the primer to POLA1 active site for DNA synthesis. Belongs to the eukaryotic-type primase large subunit family. DNA binding DNA primase activity DNA-directed 5'-3' RNA polymerase activity alpha DNA polymerase:primase complex DNA replication DNA replication, synthesis of RNA primer transferase activity nucleotidyltransferase activity metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding uc007anq.1 uc007anq.2 uc007anq.3 uc007anq.4 
ENSMUST00000027315.14 Zfp142 ENSMUST00000027315.14 zinc finger protein 142, transcript variant 1 (from RefSeq NM_001310668.1) E9PY67 ENSMUST00000027315.1 ENSMUST00000027315.10 ENSMUST00000027315.11 ENSMUST00000027315.12 ENSMUST00000027315.13 ENSMUST00000027315.2 ENSMUST00000027315.3 ENSMUST00000027315.4 ENSMUST00000027315.5 ENSMUST00000027315.6 ENSMUST00000027315.7 ENSMUST00000027315.8 ENSMUST00000027315.9 G5E869 Kiaa0236 NM_001310668 Q3V1C1 Q8BWJ0 Q8BWL4 Q8CHH6 ZN142_MOUSE Zfp142 Znf142 uc007bmn.1 uc007bmn.2 uc007bmn.3 uc007bmn.4 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=G5E869-1; Sequence=Displayed; Name=2; IsoId=G5E869-2; Sequence=VSP_060317; Name=3; IsoId=G5E869-3; Sequence=VSP_060316; Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC41402.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA polymerase II core promoter sequence-specific DNA binding nucleic acid binding regulation of gene expression nucleus histone methyltransferase complex uc007bmn.1 uc007bmn.2 uc007bmn.3 uc007bmn.4 
ENSMUST00000027322.14 Rhbdd1 ENSMUST00000027322.14 rhomboid domain containing 1, transcript variant 1 (from RefSeq NM_029777.3) ENSMUST00000027322.1 ENSMUST00000027322.10 ENSMUST00000027322.11 ENSMUST00000027322.12 ENSMUST00000027322.13 ENSMUST00000027322.2 ENSMUST00000027322.3 ENSMUST00000027322.4 ENSMUST00000027322.5 ENSMUST00000027322.6 ENSMUST00000027322.7 ENSMUST00000027322.8 ENSMUST00000027322.9 MSD-50 MSD50 NM_029777 Q8BHC7 Q99K13 Q9D5L8 RHBL4_MOUSE Rhbdl4 uc007brq.1 uc007brq.2 uc007brq.3 uc007brq.4 uc007brq.5 uc007brq.6 Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin- dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia. Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; Inhibited by aprotinin. Interacts with BIK and STEAP3 (By similarity). Interacts (via C-terminal domain) with VCP/P97. Interacts with ubiquitin and ubiquitinated proteins. Endoplasmic reticulum membrane ; Multi-pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Expressed in testis (at protein level). Expressed in intestine, lung, brain, kidney, epididymis, stomach, muscle, spleen, liver, heart and testis. Belongs to the peptidase S54 family. One study reported that the protein is not localized in the mitochondrion. endopeptidase activity serine-type endopeptidase activity protein binding mitochondrion endoplasmic reticulum endoplasmic reticulum membrane proteolysis apoptotic process spermatogenesis peptidase activity serine-type peptidase activity positive regulation of protein processing membrane integral component of membrane hydrolase activity cell differentiation integral component of endoplasmic reticulum membrane membrane protein intracellular domain proteolysis mitochondrial membrane membrane protein proteolysis cellular response to unfolded protein cellular response to UV ERAD pathway negative regulation of apoptotic process post-translational protein modification endoplasmic reticulum quality control compartment positive regulation of protein catabolic process spermatid differentiation positive regulation of secretion membrane protein proteolysis involved in retrograde protein transport, ER to cytosol regulation of male germ cell proliferation uc007brq.1 uc007brq.2 uc007brq.3 uc007brq.4 uc007brq.5 uc007brq.6 
ENSMUST00000027331.3 Tm4sf20 ENSMUST00000027331.3 transmembrane 4 L six family member 20, transcript variant 1 (from RefSeq NM_025453.4) ENSMUST00000027331.1 ENSMUST00000027331.2 NM_025453 Q9CQY8 Q9D3Q0 Q9D3R0 T4S20_MOUSE uc007bsd.1 uc007bsd.2 uc007bsd.3 Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. Membrane ; Multi- pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Ceramide alters the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20. The first transmembrane helix plays a critical role for the insertion orientation in the endoplasmic reticulum membrane. Glycosylated at Asn-132, Asn-148 and Asn-163 in presence of ceramide which inverts the orientation of TM4SF20 in membranes exposing these residues to the endoplasmic reticulum lumen. Cleaved by signal peptidase at Ser-14 but the peptide does not act as a signal peptide. Cleavage is inhibited by ceramide which inverts the orientation of TM4SF20 in membranes exposing the N-terminus to the cytosol and not to the endoplasmic reticulum lumen. Belongs to the L6 tetraspanin family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane plasma membrane focal adhesion membrane integral component of membrane negative regulation of proteolysis uc007bsd.1 uc007bsd.2 uc007bsd.3 
ENSMUST00000027338.4 Sdhaf4 ENSMUST00000027338.4 succinate dehydrogenase complex assembly factor 4 (from RefSeq NM_026503.3) ENSMUST00000027338.1 ENSMUST00000027338.2 ENSMUST00000027338.3 NM_026503 Q8BTE0 Q9CQN5 Q9D537 SDHF4_MOUSE Sdhaf4 uc007amj.1 uc007amj.2 uc007amj.3 uc007amj.4 Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit Sdha in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit Sdhb into the SDH catalytic dimer (By similarity). Interacts with Sdha in its FAD-bound form. Mitochondrion matrix Belongs to the SDHAF4 family. neural retina development mitochondrion mitochondrial matrix succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II assembly innate immune response cellular respiration uc007amj.1 uc007amj.2 uc007amj.3 uc007amj.4 
ENSMUST00000027339.14 Smap1 ENSMUST00000027339.14 small ArfGAP 1, transcript variant 1 (from RefSeq NM_028534.4) ENSMUST00000027339.1 ENSMUST00000027339.10 ENSMUST00000027339.11 ENSMUST00000027339.12 ENSMUST00000027339.13 ENSMUST00000027339.2 ENSMUST00000027339.3 ENSMUST00000027339.4 ENSMUST00000027339.5 ENSMUST00000027339.6 ENSMUST00000027339.7 ENSMUST00000027339.8 ENSMUST00000027339.9 NM_028534 Q497I6 Q68EF3 Q91VZ6 SMAP1_MOUSE uc007amh.1 uc007amh.2 uc007amh.3 uc007amh.4 GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis. Interacts with ARF6. Interacts with clathrin heavy chains via the clathrin box-like motif. Q91VZ6; Q7TN29: Smap2; NbExp=4; IntAct=EBI-8317690, EBI-11358641; Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Detected in adult brain, lung, heart, liver, ovary and bone marrow. Detected in stromal cells of the red pulp of adult spleen. Detected in stromal cells of fetal liver at 10.5 days. Expression was maximal after 14 days of development and decreased thereafter. Detected at low levels after 18 days. Sequence=AAI00538.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; GTPase activator activity protein binding cytoplasm plasma membrane membrane clathrin binding positive regulation of GTPase activity positive regulation of erythrocyte differentiation metal ion binding regulation of clathrin-dependent endocytosis actin cytoskeleton reorganization uc007amh.1 uc007amh.2 uc007amh.3 uc007amh.4 
ENSMUST00000027343.6 Ogfrl1 ENSMUST00000027343.6 opioid growth factor receptor-like 1, transcript variant 3 (from RefSeq NM_001379083.1) ENSMUST00000027343.1 ENSMUST00000027343.2 ENSMUST00000027343.3 ENSMUST00000027343.4 ENSMUST00000027343.5 NM_001379083 OGRL1_MOUSE Q8VE52 uc007amb.1 uc007amb.2 Belongs to the opioid growth factor receptor family. Sequence=AAH19747.1; Type=Erroneous initiation; Evidence=; opioid receptor activity cellular_component biological_process membrane opioid receptor signaling pathway signaling receptor activity uc007amb.1 uc007amb.2 
ENSMUST00000027356.7 Cyp27a1 ENSMUST00000027356.7 cytochrome P450, family 27, subfamily a, polypeptide 1 (from RefSeq NM_024264.5) CP27A_MOUSE Cyp27a1 ENSMUST00000027356.1 ENSMUST00000027356.2 ENSMUST00000027356.3 ENSMUST00000027356.4 ENSMUST00000027356.5 ENSMUST00000027356.6 NM_024264 Q9DBG1 uc007bna.1 uc007bna.2 uc007bna.3 uc007bna.4 Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid. Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways. May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism (By similarity). Plays a role in cholestanol metabolism in the cerebellum (PubMed:28190002). Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation. Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium. May play a redundant role in vitamin D biosynthesis. Catalyzes 25- hydroxylation of vitamin D3 that is required for its conversion to a functionally active form (By similarity). Reaction=5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy- 5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]; Xref=Rhea:RHEA:34631, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16496, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:58734; EC=1.14.15.15; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:34632; Evidence=; Reaction=cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)- 26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:53812, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:86570, ChEBI:CHEBI:137688; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53813; Evidence=; Reaction=(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:47380, Rhea:RHEA- COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:87677, ChEBI:CHEBI:87678; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47381; Evidence=; Reaction=(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:47376, Rhea:RHEA- COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:87653, ChEBI:CHEBI:87677; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47377; Evidence=; Reaction=7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:47344, Rhea:RHEA-COMP:9998, Rhea:RHEA- COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:64294, ChEBI:CHEBI:87653; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47345; Evidence=; Reaction=calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcidiol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:46588, Rhea:RHEA- COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17933, ChEBI:CHEBI:28940, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46589; Evidence=; Reaction=(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha- trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:40231, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:48939, ChEBI:CHEBI:48940; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40232; Evidence=; Reaction=cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)- cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:46400, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:76591; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46401; Evidence=; Reaction=(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26- oate + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:46436, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:86115, ChEBI:CHEBI:86116; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46437; Evidence=; Reaction=(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:46432, Rhea:RHEA- COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:86113, ChEBI:CHEBI:86115; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46433; Evidence=; Reaction=4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:46428, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:85778, ChEBI:CHEBI:86113; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46429; Evidence=; Reaction=(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:45236, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:86096, ChEBI:CHEBI:86098; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45237; Evidence=; Reaction=(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:46092, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:76591, ChEBI:CHEBI:86096; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46093; Evidence=; Reaction=(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha- trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:34627, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:48940, ChEBI:CHEBI:58734; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:34628; Evidence=; Reaction=5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-5beta-cholestane- 3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:14373, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16496, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:48939; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14374; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Hormone biosynthesis; cholecalciferol biosynthesis. Steroid metabolism; cholesterol degradation. Lipid metabolism; bile acid biosynthesis. Interacts with HSP70; this interaction is required for initial targeting to mitochondria. Mitochondrion inner membrane ; Peripheral membrane protein Note=Post-translationally targeted to mitochondria. All three of the receptor proteins in the TOM complex, TOMM70, TOMM20 and TOMM22 are required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein. Expressed in the gray and white matter of cerebellum (at protein level). Acetylation of Lys-125 and Lys-285 is observed in liver mitochondria from fasted mice but not from fed mice. Mutant mice show cholestanol accumulation in the cerebellum. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding mitochondrion mitochondrial envelope mitochondrial inner membrane lipid metabolic process steroid biosynthetic process bile acid biosynthetic process C21-steroid hormone biosynthetic process cholesterol catabolic process cholesterol 7-alpha-monooxygenase activity steroid metabolic process cholesterol metabolic process cholesterol monooxygenase (side-chain-cleaving) activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding vitamin D3 25-hydroxylase activity Hsp70 protein binding cholesterol 26-hydroxylase activity calcitriol biosynthetic process from calciol metal ion binding cholestanetriol 26-monooxygenase activity oxidation-reduction process uc007bna.1 uc007bna.2 uc007bna.3 uc007bna.4 
ENSMUST00000027358.11 Bcs1l ENSMUST00000027358.11 BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone, transcript variant 1 (from RefSeq NM_025784.5) BCS1_MOUSE ENSMUST00000027358.1 ENSMUST00000027358.10 ENSMUST00000027358.2 ENSMUST00000027358.3 ENSMUST00000027358.4 ENSMUST00000027358.5 ENSMUST00000027358.6 ENSMUST00000027358.7 ENSMUST00000027358.8 ENSMUST00000027358.9 NM_025784 Q9CZP5 uc007bmq.1 uc007bmq.2 uc007bmq.3 uc007bmq.4 The protein encoded by this gene is a chaperone protein that is involved in the assembly of complex III (CIII), one of the five protein complexes of the mitochondrial respiratory chain, and is necessary for the insertion of the Rieske iron-sulfur (RISP) and Qcr10p proteins into the precomplex. Studies from the yeast ortholog of this protein indicate that it is targeted to the inner membrane of the mitochondria, despite the absence of an N-terminal targeting sequence. Positively charged amino acids located C-terminal to the transmembrane domain are thought to act as an internal targeting signal (PMID:8599931). Mutations in the human ortholog of this gene have been associated with GRACILE syndrome, characterized by Growth retardation, Amino aciduria, Cholestasis, Iron overload, Lactic acidosis, and Early death. Mouse models with the corresponding mutation mimic the phenotype of GRACILE syndrome and display decreased complex III activity and decreased electron transport capacity (PMID:21274865). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity). Interacts with LETM1. Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the AAA ATPase family. BCS1 subfamily. nucleotide binding ATP binding mitochondrion mitochondrial inner membrane mitochondrion organization membrane integral component of membrane mitochondrial respiratory chain complex I assembly mitochondrial respiratory chain complex IV assembly mitochondrial respiratory chain complex III assembly uc007bmq.1 uc007bmq.2 uc007bmq.3 uc007bmq.4 
ENSMUST00000027362.14 Plcd4 ENSMUST00000027362.14 phospholipase C, delta 4, transcript variant 2 (from RefSeq NM_148937.2) ENSMUST00000027362.1 ENSMUST00000027362.10 ENSMUST00000027362.11 ENSMUST00000027362.12 ENSMUST00000027362.13 ENSMUST00000027362.2 ENSMUST00000027362.3 ENSMUST00000027362.4 ENSMUST00000027362.5 ENSMUST00000027362.6 ENSMUST00000027362.7 ENSMUST00000027362.8 ENSMUST00000027362.9 NM_148937 PLCD4_MOUSE Plcd Plcd4 Q3USN9 Q6NZF7 Q8CAB1 Q8K3R3 Q9CUC1 uc007bmh.1 uc007bmh.2 uc007bmh.3 Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33180; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:43484, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57880, ChEBI:CHEBI:58433; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43485; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 5 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. ; Interacts with GRIP1 (PubMed:16272139). Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunit GNAI3 (inactive GDP-bound form)l low-affinity interaction (By similarity). Membrane ; Peripheral membrane protein Nucleus Cytoplasm Endoplasmic reticulum Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8K3R3-1; Sequence=Displayed; Name=2; IsoId=Q8K3R3-2; Sequence=VSP_028503; Name=3; IsoId=Q8K3R3-3; Sequence=VSP_028503, VSP_028506; Name=4; IsoId=Q8K3R3-4; Sequence=VSP_028504, VSP_028505; By treatment with growth factors such as bradykinin, lysophosphatidic acid, and Ca(2+) ionophore in addition to serum. The PDZ-binding motif mediates the interaction with GRIP1. The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes. The PH domain is not a critical determinant of the membrane localization. The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins). Mice are either sterile or produce few small litters. In these mice, fewer eggs become activated and the Ca(2+) transients associated with fertilization are absent or delayed. Sperm are unable to initiate the acrosome reaction. phosphatidylinositol phospholipase C activity phospholipase C activity calcium ion binding nucleus cytoplasm endoplasmic reticulum cytosol plasma membrane lipid metabolic process signal transduction acrosome reaction phosphoric diester hydrolase activity membrane lipid catabolic process hydrolase activity nuclear membrane inositol trisphosphate biosynthetic process intracellular signal transduction phosphatidylinositol metabolic process metal ion binding phosphatidylinositol-mediated signaling release of sequestered calcium ion into cytosol uc007bmh.1 uc007bmh.2 uc007bmh.3 
ENSMUST00000027366.13 Vil1 ENSMUST00000027366.13 villin 1 (from RefSeq NM_009509.2) ENSMUST00000027366.1 ENSMUST00000027366.10 ENSMUST00000027366.11 ENSMUST00000027366.12 ENSMUST00000027366.2 ENSMUST00000027366.3 ENSMUST00000027366.4 ENSMUST00000027366.5 ENSMUST00000027366.6 ENSMUST00000027366.7 ENSMUST00000027366.8 ENSMUST00000027366.9 NM_009509 Q149B6 Q62468 Q91WH4 VILI_MOUSE Vil uc007bmb.1 uc007bmb.2 uc007bmb.3 uc007bmb.4 Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. Monomer. Homodimer; homodimerization is necessary for actin- bundling. Associates with F-actin; phosphorylation at tyrosine residues decreases the association with F-actin. Interacts (phosphorylated at C- terminus tyrosine phosphorylation sites) with PLCG1 (via the SH2 domains) (By similarity). Interacts (phosphorylated form) with PLCG1; the interaction is enhanced by hepatocyte growth factor (HGF). Cytoplasm, cytoskeleton Cell projection, microvillus Cell projection, lamellipodium. Cell projection, ruffle Cell projection, filopodium tip. Cell projection, filopodium. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to autotaxin, lysophosphatidic acid (LPA) and epidermal growth factor (EGF) treatment (By similarity). Relocalized in the tip of cellular protrusions and filipodial extensions upon infection with S.flexneri in primary intestinal epithelial cells (IEC) and in the tail-like structures forming the actin comets of S.flexneri. Redistributed to the leading edge of hepatocyte growth factor (HGF)-induced lamellipodia. Expressed in small intestin, colon, kidney and enterocytes (at protein level). Consists of a large core fragment in the N-terminal portion and a small headpiece (HP) in the C-terminal portion. The core fragment is necessary for both actin-nucleating and -severing activities, whereas the HP binds F-actin strongly in both the presence and absence of calcium and is necessary in actin-bundling activity. The Gelsolin-like 1 repeat is necessary for the actin-capping activity. The entire core fragment is necessary for the actin-severing activity. Two major calcium-sensitive sites are involved in conformational changes and determine separate functional properties: the first site (Glu-25, Asp- 44 and Glu-74) regulates the actin-capping and actin-severing activities; while the second site (Asp-61, Asp-86 and Ala-93) regulates only the actin-severing activity (By similarity). Phosphorylated on tyrosine residues by SRC. The unphosphorylated form increases the initial rate of actin-nucleating activity, whereas the tyrosine phosphorylated form inhibits actin-nucleating activity, enhances actin-bundling activity and enhances actin-severing activity by reducing high Ca(2+) requirements. The tyrosine phosphorylated form does not regulate actin-capping activity. Tyrosine phosphorylation is essential for cell migration: tyrosine phosphorylation sites in the N- terminus half regulate actin reorganization and cell morphology, whereas tyrosine phosphorylation sites in the C-terminus half regulate cell migration via interaction with PLCG1 (By similarity). Tyrosine phosphorylation is induced by epidermal growth factor (EGF) and stimulates cell migration. Mice are viable and fertile. The ultrastructure of the intestinal brush border is normal. Show increase epithelial cell apoptosis and are more sensitive to extran sodium sulfate-induced colitis. Newborn mice inoculated with S.flexneri are not susceptible to infection; cell invasion and intestinal inflammation were not observed, even though bacteria were seen in large number in the intestinal lumen, close to the intestinal epithelial cells (IEC) brush border. Belongs to the villin/gelsolin family. ruffle intestinal D-glucose absorption actin binding calcium ion binding protein binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm cytoskeleton plasma membrane microvillus brush border apoptotic process cytoskeleton organization epidermal growth factor receptor signaling pathway regulation of cell shape response to bacterium positive regulation of epithelial cell migration lamellipodium actin filament polymerization actin filament depolymerization filopodium positive regulation of cell migration positive regulation of actin filament depolymerization epithelial cell differentiation positive regulation of actin filament bundle assembly actin filament bundle filopodium tip regulation of microvillus length lysophosphatidic acid binding cellular response to hepatocyte growth factor stimulus positive regulation of multicellular organism growth identical protein binding protein homodimerization activity cell projection cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process actin nucleation metal ion binding actin filament severing actin filament binding barbed-end actin filament capping regulation of actin nucleation actin filament capping cytoplasmic actin-based contraction involved in cell motility regulation of wound healing cellular response to epidermal growth factor stimulus terminal web assembly positive regulation of protein localization to plasma membrane regulation of lamellipodium morphogenesis positive regulation of lamellipodium morphogenesis microvillus assembly uc007bmb.1 uc007bmb.2 uc007bmb.3 uc007bmb.4 
ENSMUST00000027367.14 Ctdsp1 ENSMUST00000027367.14 CTD small phosphatase 1, transcript variant 2 (from RefSeq NM_153088.3) Ctdsp1 ENSMUST00000027367.1 ENSMUST00000027367.10 ENSMUST00000027367.11 ENSMUST00000027367.12 ENSMUST00000027367.13 ENSMUST00000027367.2 ENSMUST00000027367.3 ENSMUST00000027367.4 ENSMUST00000027367.5 ENSMUST00000027367.6 ENSMUST00000027367.7 ENSMUST00000027367.8 ENSMUST00000027367.9 NM_153088 Q5I0X8 Q5I0X8_MOUSE uc007blz.1 uc007blz.2 uc007blz.3 uc007blz.4 Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter protein dephosphorylation CTD phosphatase activity phosphatase activity uc007blz.1 uc007blz.2 uc007blz.3 uc007blz.4 
ENSMUST00000027368.6 Slc11a1 ENSMUST00000027368.6 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (from RefSeq NM_013612.2) Bcg ENSMUST00000027368.1 ENSMUST00000027368.2 ENSMUST00000027368.3 ENSMUST00000027368.4 ENSMUST00000027368.5 Ity Lsh NM_013612 NRAM1_MOUSE Nramp1 P41251 Q3TB84 uc007bly.1 uc007bly.2 uc007bly.3 uc007bly.4 Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. Reaction=H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out); Xref=Rhea:RHEA:28839, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105; Evidence=; Reaction=Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in); Xref=Rhea:RHEA:29439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033; Evidence=; Reaction=H(+)(out) + Mn(2+)(in) = H(+)(in) + Mn(2+)(out); Xref=Rhea:RHEA:73063, ChEBI:CHEBI:15378, ChEBI:CHEBI:29035; Evidence=; Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Note=After onfection, vesicles migrate to the site of bacterial phagosomes. Macrophages; spleen and liver. In response to lymphokine, such as IFNG, or bacterial products, such as LPS (PubMed:7665187, PubMed:9730978). Induced in macrophages at early stages of infection (PubMed:7665187). Glycosylated. Variant Asp-169 is displayed in the entry because it is the variant found in the inbred strains C57BL/6J and BALB/cJ and even if it seems to not be expressed in its mature form. In inbred strains, the susceptibility to infection with unrelated intracellular parasites, such as Mycobacterium bovis, Salmonella typhimurium and Leishmania donovani is associated with the single glycine-to-aspartic acid substitution at position 169 (G169D) in the predicted transmembrane domain 4. The conserved and resistant Gly-169 variant show the proper transporter activity described in the function and is highly induced in response to lymphokine, such as IFNG, or bacterial products, such as LPS. However the variant Asp-169 shows an altered glycosylated pattern and seems to prevent proper maturation of the protein, resulting in its rapid degradation. The expression of the mature form of variant Asp-169 is strongly decreased in late endosome/lysosome membranes leading to a reduced phagosome-lysosome fusion in macrophages after infection. Belongs to the NRAMP family. The variant Asp-169 displayed in the entry is the variant found in the inbred strains C57BL/6J and BALB/cJ and may be expressed at very low levels in its mature form. In inbred strains, the susceptibility to infection with unrelated intracellular parasites, such as Mycobacterium bovis, Salmonella typhimurium and Leishmania donovani is associated with the single glycine-to-aspartic acid substitution at position 169 (G169D) in the predicted transmembrane domain 4. The conserved and resistant Gly-169 variant show the proper transporter activity described. However the variant Asp-169 shows an altered glycosylated pattern and seems to prevent proper maturation of the protein, resulting in its rapid degradation. The expression of the mature form of variant Asp-169 is strongly decreased in late endosome/lysosome membranes leading to a reduced phagosome-lysosome fusion in macrophages after infection. MAPK cascade negative regulation of cytokine production positive regulation of cytokine production T cell proliferation involved in immune response T cell cytokine production positive regulation of dendritic cell antigen processing and presentation positive regulation of T-helper 1 type immune response iron ion transmembrane transporter activity manganese ion transmembrane transporter activity lysosome late endosome plasma membrane ion transport iron ion transport manganese ion transport cellular cadmium ion homeostasis cellular iron ion homeostasis phagocytosis inflammatory response vacuolar acidification response to bacterium endosome membrane positive regulation of gene expression cadmium ion transmembrane transporter activity nitrite transport membrane integral component of membrane metal ion transport phagocytic vesicle membrane activation of protein kinase activity response to lipopolysaccharide interleukin-2 production interleukin-3 production positive regulation of interferon-gamma production response to interferon-gamma iron ion transmembrane transport wound healing macrophage activation defense response to bacterium protein homodimerization activity defense response to protozoan MHC class II biosynthetic process respiratory burst positive regulation of transcription from RNA polymerase II promoter metal ion transmembrane transporter activity transition metal ion transmembrane transporter activity antigen processing and presentation of peptide antigen mRNA stabilization positive regulation of phagocytosis defense response to Gram-negative bacterium metal ion:proton antiporter activity iron ion homeostasis multicellular organismal iron ion homeostasis cadmium ion transmembrane transport tertiary granule membrane divalent metal ion export manganese ion transmembrane transport L-arginine transport cell surface uc007bly.1 uc007bly.2 uc007bly.3 uc007bly.4 
ENSMUST00000027373.12 Ppm1f ENSMUST00000027373.12 protein phosphatase 1F (PP2C domain containing) (from RefSeq NM_176833.4) ENSMUST00000027373.1 ENSMUST00000027373.10 ENSMUST00000027373.11 ENSMUST00000027373.2 ENSMUST00000027373.3 ENSMUST00000027373.4 ENSMUST00000027373.5 ENSMUST00000027373.6 ENSMUST00000027373.7 ENSMUST00000027373.8 ENSMUST00000027373.9 NM_176833 PPM1F_MOUSE Q8CGA0 uc007yjo.1 uc007yjo.2 uc007yjo.3 uc007yjo.4 Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis (By similarity). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit. ; Associates with FEM1B. Expressed in the liver. Belongs to the PP2C family. catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity nucleus cytosol negative regulation of protein kinase activity protein dephosphorylation apoptotic process protein tyrosine/serine/threonine phosphatase activity positive regulation of gene expression positive regulation of epithelial cell migration positive regulation of cell-substrate adhesion histone dephosphorylation hydrolase activity positive regulation of cell migration macromolecular complex negative regulation of peptidyl-serine phosphorylation calmodulin-dependent protein phosphatase activity cellular response to drug peptidyl-threonine dephosphorylation cation binding positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of protein kinase activity by regulation of protein phosphorylation negative regulation of transcription, DNA-templated positive regulation of growth metal ion binding perinuclear region of cytoplasm positive regulation of chemotaxis negative regulation of protein transport positive regulation of stress fiber assembly positive regulation of focal adhesion assembly peptidyl-serine dephosphorylation intrinsic apoptotic signaling pathway regulation of cellular protein localization negative regulation of cell-cell adhesion mediated by cadherin uc007yjo.1 uc007yjo.2 uc007yjo.3 uc007yjo.4 
ENSMUST00000027374.7 Tnp1 ENSMUST00000027374.7 transition protein 1 (from RefSeq NM_009407.2) ENSMUST00000027374.1 ENSMUST00000027374.2 ENSMUST00000027374.3 ENSMUST00000027374.4 ENSMUST00000027374.5 ENSMUST00000027374.6 NM_009407 Q545L6 Q545L6_MOUSE Tnp1 uc007bkz.1 uc007bkz.2 uc007bkz.3 uc007bkz.4 uc007bkz.5 Chromosome Nucleus Belongs to the nuclear transition protein 1 family. single strand break repair nucleosome male germ cell nucleus DNA binding nucleus nucleosome disassembly chromatin remodeling chromatin silencing spermatogenesis spermatid development spermatid nucleus elongation sexual reproduction flagellated sperm motility negative regulation of transcription, DNA-templated uc007bkz.1 uc007bkz.2 uc007bkz.3 uc007bkz.4 uc007bkz.5 
ENSMUST00000027377.9 Igfbp5 ENSMUST00000027377.9 insulin-like growth factor binding protein 5 (from RefSeq NM_010518.2) ENSMUST00000027377.1 ENSMUST00000027377.2 ENSMUST00000027377.3 ENSMUST00000027377.4 ENSMUST00000027377.5 ENSMUST00000027377.6 ENSMUST00000027377.7 ENSMUST00000027377.8 Igfbp5 NM_010518 Q3UQV0 Q3UQV0_MOUSE uc007bkx.1 uc007bkx.2 uc007bkx.3 IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Secreted Lacks conserved residue(s) required for the propagation of feature annotation. insulin-like growth factor binding extracellular region aging negative regulation of smooth muscle cell migration negative regulation of translation negative regulation of cell migration insulin-like growth factor I binding intracellular signal transduction insulin-like growth factor ternary complex negative regulation of insulin-like growth factor receptor signaling pathway negative regulation of smooth muscle cell proliferation response to growth hormone cellular response to cAMP cellular response to organic cyclic compound positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration uc007bkx.1 uc007bkx.2 uc007bkx.3 
ENSMUST00000027379.10 Xrcc5 ENSMUST00000027379.10 X-ray repair complementing defective repair in Chinese hamster cells 5, transcript variant 1 (from RefSeq NM_009533.2) ENSMUST00000027379.1 ENSMUST00000027379.2 ENSMUST00000027379.3 ENSMUST00000027379.4 ENSMUST00000027379.5 ENSMUST00000027379.6 ENSMUST00000027379.7 ENSMUST00000027379.8 ENSMUST00000027379.9 G22p2 NM_009533 P27641 Q3TE46 Q3TJT0 Q3TN82 Q80UT1 Q8C4N6 Q8K1K7 Q9R169 XRCC5_MOUSE uc007bkl.1 uc007bkl.2 uc007bkl.3 uc007bkl.4 uc007bkl.5 Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double- stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection. Binding to DNA may be mediated by XRCC6. The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA- dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription. In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small- subunit processome. Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Heterodimer composed of XRCC5/Ku80 and XRCC6/Ku70 (By similarity). Component of the core long-range non-homologous end joining (NHEJ) complex (also named DNA-PK complex) composed of PRKDC, LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF (By similarity). Additional component of the NHEJ complex includes PAXX (By similarity). Following autophosphorylation, PRKDC dissociates from DNA, leading to formation of the short-range NHEJ complex, composed of LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF (By similarity). The XRCC5-XRCC6 dimer also associates with NAA15, and this complex displays DNA binding activity towards the osteocalcin FGF response element (OCFRE) (By similarity). In addition, XRCC5 binds to the osteoblast-specific transcription factors MSX2 and RUNX2 (By similarity). Interacts with ELF3 (By similarity). Interacts with APLF (via KBM motif) (By similarity). The XRCC5/XRCC6 dimer associates in a DNA-dependent manner with APEX1 (By similarity). Identified in a complex with DEAF1 and XRCC6 (By similarity). Interacts with NR4A3; the DNA-dependent protein kinase complex DNA-PK phosphorylates and activates NR4A3 and prevents NR4A3 ubiquitinylation and degradation (By similarity). Interacts with RNF138 (By similarity). Interacts with CYREN (via KBM motif) (PubMed:30017584). Interacts with WRN (via KBM motif) (By similarity). Interacts (via N-terminus) with HSF1 (via N-terminus); this interaction is direct and prevents XRCC5/XRCC6 heterodimeric binding and non- homologous end joining (NHEJ) repair activities induced by ionizing radiation (IR) (By similarity). Interacts with DHX9; this interaction occurs in a RNA-dependent manner (By similarity). Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA (By similarity). Interacts with ERCC6 (By similarity). Interacts with ATF7 (By similarity). The XRCC5-XRCC6 dimer associates with ALKBH2. Nucleus Nucleus, nucleolus Chromosome Expression increases during promyelocyte differentiation. Up-regulation during myogenesis is inhibited by cAMP, 3- aminobenzamide and sodium butyrate. Expression in myoblasts is unaffected by X-rays and UV light. The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage. ADP-ribosylated by PARP3. Phosphorylated on serine residues. Phosphorylation by PRKDC may enhance helicase activity. Sumoylated. Ubiquitinated by RNF8 via 'Lys-48'-linked ubiquitination following DNA damage, leading to its degradation and removal from DNA damage sites. Ubiquitinated by RNF138, leading to remove the Ku complex from DNA breaks. Belongs to the ku80 family. nucleotide binding telomere maintenance nuclear chromosome, telomeric region activation of innate immune response immune system process DNA binding DNA helicase activity damaged DNA binding double-stranded DNA binding double-stranded telomeric DNA binding RNA binding helicase activity protein binding ATP binding nucleus nucleoplasm chromosome nucleolus cytoplasm plasma membrane DNA repair double-strand break repair double-strand break repair via nonhomologous end joining DNA recombination cellular response to DNA damage stimulus brain development protein C-terminus binding cell proliferation hydrolase activity hydrolase activity, acting on acid anhydrides ubiquitin protein ligase binding positive regulation of telomere maintenance via telomerase DNA duplex unwinding macromolecular complex protein-DNA complex telomeric DNA binding response to drug Ku70:Ku80 complex transcription regulatory region DNA binding macromolecular complex binding DNA end binding innate immune response positive regulation of protein kinase activity negative regulation of transcription, DNA-templated regulation of smooth muscle cell proliferation positive regulation of neurogenesis 5'-deoxyribose-5-phosphate lyase activity hematopoietic stem cell differentiation nonhomologous end joining complex cellular response to fatty acid cellular hyperosmotic salinity response cellular response to gamma radiation cellular response to X-ray negative regulation of t-circle formation cellular response to leukemia inhibitory factor ribonucleoprotein complex uc007bkl.1 uc007bkl.2 uc007bkl.3 uc007bkl.4 uc007bkl.5 
ENSMUST00000027380.12 Tmem169 ENSMUST00000027380.12 transmembrane protein 169, transcript variant 1 (from RefSeq NM_175564.5) ENSMUST00000027380.1 ENSMUST00000027380.10 ENSMUST00000027380.11 ENSMUST00000027380.2 ENSMUST00000027380.3 ENSMUST00000027380.4 ENSMUST00000027380.5 ENSMUST00000027380.6 ENSMUST00000027380.7 ENSMUST00000027380.8 ENSMUST00000027380.9 NM_175564 Q8BG50 TM169_MOUSE uc007bkk.1 uc007bkk.2 uc007bkk.3 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007bkk.1 uc007bkk.2 uc007bkk.3 
ENSMUST00000027381.13 Pecr ENSMUST00000027381.13 peroxisomal trans-2-enoyl-CoA reductase, transcript variant 1 (from RefSeq NM_023523.6) ENSMUST00000027381.1 ENSMUST00000027381.10 ENSMUST00000027381.11 ENSMUST00000027381.12 ENSMUST00000027381.2 ENSMUST00000027381.3 ENSMUST00000027381.4 ENSMUST00000027381.5 ENSMUST00000027381.6 ENSMUST00000027381.7 ENSMUST00000027381.8 ENSMUST00000027381.9 NM_023523 PECR_MOUSE Pecr Q99MZ7 Q9CX01 Q9JIF4 uc007bki.1 uc007bki.2 uc007bki.3 uc007bki.4 Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity. Reaction=a (2E)-enoyl-CoA + H(+) + NADPH = a 2,3-saturated acyl-CoA + NADP(+); Xref=Rhea:RHEA:33763, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58856, ChEBI:CHEBI:65111; EC=1.3.1.38; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33764; Evidence=; Reaction=(2E)-hexenoyl-CoA + H(+) + NADPH = hexanoyl-CoA + NADP(+); Xref=Rhea:RHEA:44956, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62077, ChEBI:CHEBI:62620; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44957; Evidence=; Reaction=(2E)-octenoyl-CoA + H(+) + NADPH = NADP(+) + octanoyl-CoA; Xref=Rhea:RHEA:44952, ChEBI:CHEBI:15378, ChEBI:CHEBI:57386, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62242; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44953; Evidence=; Reaction=(2E)-decenoyl-CoA + H(+) + NADPH = decanoyl-CoA + NADP(+); Xref=Rhea:RHEA:44960, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61406, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44961; Evidence=; Reaction=(2E)-dodecenoyl-CoA + H(+) + NADPH = dodecanoyl-CoA + NADP(+); Xref=Rhea:RHEA:44964, ChEBI:CHEBI:15378, ChEBI:CHEBI:57330, ChEBI:CHEBI:57375, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44965; Evidence=; Reaction=(2E)-tetradecenoyl-CoA + H(+) + NADPH = NADP(+) + tetradecanoyl-CoA; Xref=Rhea:RHEA:44968, ChEBI:CHEBI:15378, ChEBI:CHEBI:57385, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61405; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44969; Evidence=; Lipid metabolism; fatty acid biosynthesis. Interacts with PEX5, probably required to target it into peroxisomes. Peroxisome Highly expressed in liver and kidney. Expressed at lowe level in heart and skeletal muscle. Expressed at weak level in other tissues. Belongs to the short-chain dehydrogenases/reductases (SDR) family. receptor binding mitochondrion peroxisome peroxisomal membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process oxidoreductase activity trans-2-enoyl-CoA reductase (NADPH) activity fatty acid elongation phytol metabolic process intracellular membrane-bounded organelle oxidation-reduction process uc007bki.1 uc007bki.2 uc007bki.3 uc007bki.4 
ENSMUST00000027384.6 Atic ENSMUST00000027384.6 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (from RefSeq NM_026195.3) ENSMUST00000027384.1 ENSMUST00000027384.2 ENSMUST00000027384.3 ENSMUST00000027384.4 ENSMUST00000027384.5 NM_026195 PUR9_MOUSE Purh Q3UTQ3 Q80UH0 Q8BPF0 Q8BQV9 Q9CRI1 Q9CWJ9 Q9CZW9 uc007bjt.1 uc007bjt.2 uc007bjt.3 uc007bjt.4 Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:29072452). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5- phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:29072452). Also displays cyclohydrolase activity involving the cyclization of FAICAR to IMP. Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity). Reaction=(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide; Xref=Rhea:RHEA:22192, ChEBI:CHEBI:57453, ChEBI:CHEBI:58467, ChEBI:CHEBI:58475, ChEBI:CHEBI:195366; EC=2.1.2.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22193; Evidence=; Reaction=10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate; Xref=Rhea:RHEA:59144, ChEBI:CHEBI:57451, ChEBI:CHEBI:57452, ChEBI:CHEBI:58467, ChEBI:CHEBI:58475; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59145; Evidence=; Reaction=H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide; Xref=Rhea:RHEA:18445, ChEBI:CHEBI:15377, ChEBI:CHEBI:58053, ChEBI:CHEBI:58467; EC=3.5.4.10; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18447; Evidence=; AMP and XMP inhibit AICAR formyltransferase activity (By similarity). AICAR formyltransferase activity is inhibited by N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5- [(3R)-3- hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), which acts as a tumor suppression in cancer cell lines (PubMed:29072452). Purine metabolism; IMP biosynthesis via de novo pathway; 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino- 1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. Homodimer. Associates with internalized INSR complexes on Golgi/endosomal membranes. Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis. Cytoplasm, cytosol The IMP cyclohydrolase activity resides in the N-terminal region. The de novo purine synthesis pathway includes 10 sequential steps, beginning with phosphoribosyl pyrophosphate and ending with inositol monophosphate (IMP), the first purin compound of the pathway. Belongs to the PurH family. Sequence=BAB28011.1; Type=Frameshift; Evidence=; brainstem development catalytic activity IMP cyclohydrolase activity phosphoribosylaminoimidazolecarboxamide formyltransferase activity mitochondrion cytosol plasma membrane purine nucleotide biosynthetic process 'de novo' IMP biosynthetic process metabolic process nucleoside metabolic process ribonucleotide metabolic process response to inorganic substance transferase activity hydrolase activity cerebellum development cerebral cortex development animal organ regeneration protein homodimerization activity dihydrofolate metabolic process tetrahydrofolate biosynthetic process cellular response to interleukin-7 uc007bjt.1 uc007bjt.2 uc007bjt.3 uc007bjt.4 
ENSMUST00000027393.8 Bard1 ENSMUST00000027393.8 BRCA1 associated RING domain 1, transcript variant 1 (from RefSeq NM_007525.3) A2VCQ1 BARD1_MOUSE ENSMUST00000027393.1 ENSMUST00000027393.2 ENSMUST00000027393.3 ENSMUST00000027393.4 ENSMUST00000027393.5 ENSMUST00000027393.6 ENSMUST00000027393.7 NM_007525 O70445 uc007bjm.1 uc007bjm.2 uc007bjm.3 uc007bjm.4 E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homo- and heterodimer. Heterodimer (RING-type zinc finger) with BRCA1. Heterodimer (via ANK repeats and BRCT domains) with CSTF1/CSTF-50. Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts with UBXN1. Nucleus Cytoplasm Note=Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex. Processed during apoptosis. The homodimer is more susceptible to proteolytic cleavage than the BARD1/BRCA1 heterodimer. RNA binding ubiquitin-protein transferase activity nucleus cytoplasm DNA repair cellular response to DNA damage stimulus protein ubiquitination nuclear speck transferase activity BRCA1-BARD1 complex cytoplasmic ribonucleoprotein granule regulation of phosphorylation protein homodimerization activity positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of protein export from nucleus metal ion binding protein heterodimerization activity BRCA1-A complex protein K6-linked ubiquitination uc007bjm.1 uc007bjm.2 uc007bjm.3 uc007bjm.4 
ENSMUST00000027396.15 Abcb6 ENSMUST00000027396.15 ATP-binding cassette, sub-family B member 6 (from RefSeq NM_023732.3) ABCB6_MOUSE Abcb6 ENSMUST00000027396.1 ENSMUST00000027396.10 ENSMUST00000027396.11 ENSMUST00000027396.12 ENSMUST00000027396.13 ENSMUST00000027396.14 ENSMUST00000027396.2 ENSMUST00000027396.3 ENSMUST00000027396.4 ENSMUST00000027396.5 ENSMUST00000027396.6 ENSMUST00000027396.7 ENSMUST00000027396.8 ENSMUST00000027396.9 NM_023732 Q3U7N5 Q3UAZ6 Q9DC29 uc007bnx.1 uc007bnx.2 uc007bnx.3 uc007bnx.4 uc007bnx.5 ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (PubMed:27507172). May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (PubMed:22294697, PubMed:17006453). May play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (By similarity). In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5- fluorouracil, SN-38 and vincristin (By similarity). In addition may play a role in the transition metal homeostasis (By similarity). Reaction=ATP + coproporphyrin III(in) + H2O = ADP + coproporphyrin III(out) + H(+) + phosphate; Xref=Rhea:RHEA:66664, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:131725, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66665; Evidence=; Reaction=ATP + coproporphyrinogen III(in) + H2O = ADP + coproporphyrinogen III(out) + H(+) + phosphate; Xref=Rhea:RHEA:66680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57309, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66681; Evidence=; Reaction=ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate; Xref=Rhea:RHEA:19261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:60344, ChEBI:CHEBI:456216; EC=7.6.2.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19262; Evidence=; Reaction=ATP + H2O + pheophorbide a(in) = ADP + H(+) + pheophorbide a(out) + phosphate; Xref=Rhea:RHEA:61360, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58687, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61361; Evidence=; Reaction=ATP + H2O + protoporphyrin IX(in) = ADP + H(+) + phosphate + protoporphyrin IX(out); Xref=Rhea:RHEA:61336, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57306, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61337; Evidence=; Reaction=ATP + coproporphyrin I(in) + H2O = ADP + coproporphyrin I(out) + H(+) + phosphate; Xref=Rhea:RHEA:66768, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:167478, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66769; Evidence=; Reaction=ATP + H2O + uroporphyrin I(in) = ADP + H(+) + phosphate + uroporphyrin I(out); Xref=Rhea:RHEA:66772, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:167480, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66773; Evidence=; Reaction=ATP + H2O + uroporphyrin III(in) = ADP + H(+) + phosphate + uroporphyrin III(out); Xref=Rhea:RHEA:66776, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:167479, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66777; Evidence=; Kinetic parameters: KM=12.6 uM for coproporphyrin III ; Vmax=9.8 pmol/min/mg enzyme toward coproporphyrin III; Vmax=59.4 pmol/min/mg enzyme toward coproporphyrin III ; Homodimer. Cell membrane ; Multi-pass membrane protein Mitochondrion outer membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Lysosome membrane Late endosome membrane Early endosome membrane Secreted, extracellular exosome Mitochondrion Endosome, multivesicular body membrane Melanosome membrane Note=Present in the membrane of mature erythrocytes and in exosomes released from reticulocytes during the final steps of erythroid maturation. Traffics from endoplasmic reticulum to Golgi during its glycans's maturation, therefrom is first targeted to the plasma membrane, and is rapidly internalized through endocytosis to be distributed to the limiting membrane of multivesicular bodies and lysosomes. Localized on the limiting membrane of early melanosomes of pigment cells (By similarity). Targeted to the endolysosomal compartment (By similarity). Highly expressed in embryonic liver. Up-regulated during erythroid differentiation and heme biosynthesis (PubMed:17006453, PubMed:22294697). Up-regulated by cellular porphyrins (at protein level) (PubMed:17006453). Up-regulated in red blood cells under anemic condition (PubMed:22655043). Induced by sodium arsenite in a dose-dependent manner (PubMed:21266531). Contains two independently folding units, the N-terminal transmembrane domain (residues 1-205) and the ABC-core domain (206-842) are respectively responsible for the lysosomal targeting and the ATPase activity. N-glycosylated. Homozygous knockout mice for Abcb6 gene appear phenotypically normal (PubMed:22294697). In a ferrochelatase-deficient mouse model where Abcb6 has been homozygously disrupted, mice exacerbate porphyria phenotypes shown by increased porphyrin accumulation, and marked liver injury (PubMed:27507172). Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. To date, the intracellular localization of ABCB6 is a matter of debate, with conflicting reports suggesting mitochondrial or endolysosomal localization, therefore questioning the requirement of ABCB6 in the mitochondrial import of porphyrins. Sequence=BAE30168.1; Type=Frameshift; Evidence=; Golgi membrane nucleotide binding ATP binding nucleoplasm mitochondrion mitochondrial envelope mitochondrial outer membrane endosome vacuolar membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol plasma membrane porphyrin-containing compound biosynthetic process brain development endosome membrane heme-transporting ATPase activity efflux transmembrane transporter activity heme transport membrane integral component of membrane ATPase activity heme binding integral component of mitochondrial outer membrane heme transmembrane transport ATPase activity, coupled to transmembrane movement of substances skin development transmembrane transport uc007bnx.1 uc007bnx.2 uc007bnx.3 uc007bnx.4 uc007bnx.5 
ENSMUST00000027401.11 Stk16 ENSMUST00000027401.11 serine/threonine kinase 16, transcript variant 3 (from RefSeq NR_102731.1) ENSMUST00000027401.1 ENSMUST00000027401.10 ENSMUST00000027401.2 ENSMUST00000027401.3 ENSMUST00000027401.4 ENSMUST00000027401.5 ENSMUST00000027401.6 ENSMUST00000027401.7 ENSMUST00000027401.8 ENSMUST00000027401.9 Edpk Krct Mpsk1 NR_102731 O88697 Pkl12 Q3UEG5 Q9JMJ0 Q9JMJ1 Q9QX00 STK16_MOUSE Tsf1 uc007boh.1 uc007boh.2 uc007boh.3 uc007boh.4 Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates (By similarity). May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Monomer. Interacts with DRG1 (via its N-terminal); the interaction phosphorylates DRG1. Cytoplasm, perinuclear region Membrane ; Lipid-anchor Note=Associates with Golgi and Golgi-derived vesicles. Ubiquitously expressed at low levels. Relatively higher levels in testis, kidney and liver. Expressed at all stages of developing embryo. Mainly autophosphorylated on serine/threonine residues. Also autophosphorylated on Tyr-198 (By similarity). Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein kinase activity protein serine/threonine kinase activity non-membrane spanning protein tyrosine kinase activity ATP binding cytoplasm Golgi-associated vesicle cytosol protein phosphorylation membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation perinuclear region of cytoplasm cellular response to transforming growth factor beta stimulus uc007boh.1 uc007boh.2 uc007boh.3 uc007boh.4 
ENSMUST00000027404.12 Ptprn ENSMUST00000027404.12 protein tyrosine phosphatase receptor type N, transcript variant 5 (from RefSeq NR_175909.1) A6MDD2 A6MDD2_MOUSE ENSMUST00000027404.1 ENSMUST00000027404.10 ENSMUST00000027404.11 ENSMUST00000027404.2 ENSMUST00000027404.3 ENSMUST00000027404.4 ENSMUST00000027404.5 ENSMUST00000027404.6 ENSMUST00000027404.7 ENSMUST00000027404.8 ENSMUST00000027404.9 NR_175909 Ptprn uc007boq.1 uc007boq.2 uc007boq.3 Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. response to reactive oxygen species nucleus endosome Golgi apparatus plasma membrane transcription factor binding response to glucose membrane integral component of membrane hydrolase activity cytokine-mediated signaling pathway insulin secretion secretory granule spectrin binding response to insulin insulin secretion involved in cellular response to glucose stimulus neuronal cell body response to estrogen axon terminus ubiquitin-like protein ligase binding synapse positive regulation of transcription from RNA polymerase II promoter GTPase binding response to cAMP positive regulation of type B pancreatic cell proliferation dense core granule maturation uc007boq.1 uc007boq.2 uc007boq.3 
ENSMUST00000027405.6 Slc23a3 ENSMUST00000027405.6 solute carrier family 23 (nucleobase transporters), member 3 (from RefSeq NM_194333.3) A0A0R4J067 A0A0R4J067_MOUSE ENSMUST00000027405.1 ENSMUST00000027405.2 ENSMUST00000027405.3 ENSMUST00000027405.4 ENSMUST00000027405.5 NM_194333 Slc23a3 uc007bno.1 uc007bno.2 uc007bno.3 Membrane ; Multi- pass membrane protein Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. membrane integral component of membrane transmembrane transporter activity transmembrane transport uc007bno.1 uc007bno.2 uc007bno.3 
ENSMUST00000027409.10 Des ENSMUST00000027409.10 desmin (from RefSeq NM_010043.2) Des ENSMUST00000027409.1 ENSMUST00000027409.2 ENSMUST00000027409.3 ENSMUST00000027409.4 ENSMUST00000027409.5 ENSMUST00000027409.6 ENSMUST00000027409.7 ENSMUST00000027409.8 ENSMUST00000027409.9 NM_010043 Q3V1K9 Q3V1K9_MOUSE uc007box.1 uc007box.2 uc007box.3 uc007box.4 This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane and are essential for maintaining the strength and integrity of skeletal, cardiac and smooth muscle fibers. Mutations in this gene affect assembly of intermediate filaments. Mice lacking this gene are able to develop and reproduce but exhibit abnormal muscle fibers. Mutations in the human gene are associated with myofibrillar myopathy, dilated cardiomyopathy, neurogenic scapuloperoneal syndrome and autosomal recessive limb-girdle muscular dystrophy, type 2R. [provided by RefSeq, Jan 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK132391.1, AK131922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane, sarcolemma Cytoplasm, myofibril, sarcomere, Z line Belongs to the intermediate filament family. intermediate filament cytoskeletal protein binding intercalated disc Z disc sarcolemma identical protein binding intermediate filament organization intermediate filament cytoskeleton cardiac myofibril uc007box.1 uc007box.2 uc007box.3 uc007box.4 
ENSMUST00000027414.16 Stk11ip ENSMUST00000027414.16 serine/threonine kinase 11 interacting protein (from RefSeq NM_027886.3) ENSMUST00000027414.1 ENSMUST00000027414.10 ENSMUST00000027414.11 ENSMUST00000027414.12 ENSMUST00000027414.13 ENSMUST00000027414.14 ENSMUST00000027414.15 ENSMUST00000027414.2 ENSMUST00000027414.3 ENSMUST00000027414.4 ENSMUST00000027414.5 ENSMUST00000027414.6 ENSMUST00000027414.7 ENSMUST00000027414.8 ENSMUST00000027414.9 Lip1 Lkb1ip NM_027886 Q3TAA7 Q6P7J8 Q9DBT7 S11IP_MOUSE uc007bpt.1 uc007bpt.2 uc007bpt.3 May regulate STK11/LKB1 function by controlling its subcellular localization. Found in a ternary complex composed of STK11/LKB1, STK11IP and SMAD4 (By similarity). Interacts with SMAD4 (By similarity). Interacts with STK11/LKB1. Cytoplasm Note=Some cells show granular or punctuate expression. Colocalizes with STK11/LKB1 and SMAD4 in granular or punctuate structures (By similarity). Belongs to the STK11IP family. cytoplasm protein localization protein kinase binding uc007bpt.1 uc007bpt.2 uc007bpt.3 
ENSMUST00000027422.7 Slc16a14 ENSMUST00000027422.7 solute carrier family 16 (monocarboxylic acid transporters), member 14, transcript variant 1 (from RefSeq NM_027921.2) ENSMUST00000027422.1 ENSMUST00000027422.2 ENSMUST00000027422.3 ENSMUST00000027422.4 ENSMUST00000027422.5 ENSMUST00000027422.6 MOT14_MOUSE Mct14 NM_027921 Q8K1C7 Q9D1K0 uc007btd.1 uc007btd.2 uc007btd.3 Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Cell membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. Sequence=BAB22782.1; Type=Erroneous initiation; Evidence=; Sequence=BAC33953.1; Type=Erroneous initiation; Evidence=; plasma membrane integral component of plasma membrane monocarboxylic acid transmembrane transporter activity symporter activity monocarboxylic acid transport membrane integral component of membrane transmembrane transport uc007btd.1 uc007btd.2 uc007btd.3 
ENSMUST00000027425.16 Itm2c ENSMUST00000027425.16 integral membrane protein 2C (from RefSeq NM_022417.3) ENSMUST00000027425.1 ENSMUST00000027425.10 ENSMUST00000027425.11 ENSMUST00000027425.12 ENSMUST00000027425.13 ENSMUST00000027425.14 ENSMUST00000027425.15 ENSMUST00000027425.2 ENSMUST00000027425.3 ENSMUST00000027425.4 ENSMUST00000027425.5 ENSMUST00000027425.6 ENSMUST00000027425.7 ENSMUST00000027425.8 ENSMUST00000027425.9 ITM2C_MOUSE NM_022417 Q91VK4 Q9JI06 Q9JME8 uc011wof.1 uc011wof.2 uc011wof.3 Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. Interacts with BACE1. Interacts with APP. Interacts with STMN2 (By similarity). Lysosome membrane ; Single-pass type II membrane protein Cell membrane ; Single-pass type II membrane protein Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B (By similarity). Belongs to the ITM2 family. beta-amyloid binding ATP binding lysosome lysosomal membrane Golgi apparatus plasma membrane negative regulation of neuron projection development membrane integral component of membrane neuron differentiation negative regulation of amyloid precursor protein biosynthetic process perinuclear region of cytoplasm positive regulation of extrinsic apoptotic signaling pathway uc011wof.1 uc011wof.2 uc011wof.3 
ENSMUST00000027426.11 4933407L21Rik ENSMUST00000027426.11 RIKEN cDNA 4933407L21 gene (from RefSeq NR_037692.1) 4933407L21Rik ENSMUST00000027426.1 ENSMUST00000027426.10 ENSMUST00000027426.2 ENSMUST00000027426.3 ENSMUST00000027426.4 ENSMUST00000027426.5 ENSMUST00000027426.6 ENSMUST00000027426.7 ENSMUST00000027426.8 ENSMUST00000027426.9 NR_037692 Q9D476 Q9D476_MOUSE uc287jym.1 uc287jym.2 molecular_function cellular_component biological_process uc287jym.1 uc287jym.2 
ENSMUST00000027431.7 Htr2b ENSMUST00000027431.7 5-hydroxytryptamine (serotonin) receptor 2B (from RefSeq NM_008311.3) 5HT2B_MOUSE ENSMUST00000027431.1 ENSMUST00000027431.2 ENSMUST00000027431.3 ENSMUST00000027431.4 ENSMUST00000027431.5 ENSMUST00000027431.6 NM_008311 Q02152 Q8JZK5 Q9QWS2 uc007buz.1 uc007buz.2 uc007buz.3 G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1426253). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:1426253, PubMed:16940156). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and downstream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity (PubMed:16940156, PubMed:18337424). May play a role in the perception of pain (PubMed:21273425). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development (PubMed:10944220, PubMed:11413089). Protects cardiomyocytes against apoptosis (PubMed:12738797). Plays a role in the adaptation of pulmonary arteries to chronic hypoxia (PubMed:12244304). Plays a role in vasoconstriction (PubMed:12244304, PubMed:23346101). Required for normal osteoblast function and proliferation, and for maintaining normal bone density (PubMed:17846081). Required for normal proliferation of the interstitial cells of Cajal in the intestine (PubMed:19941613). Interacts (via C-terminus) with MPDZ. Cell membrane ; Multi-pass membrane protein Synapse, synaptosome Ubiquitous. Detected in intestine, heart, skeletal muscle, testis, urinary bladder, stomach, liver, lung, brain and kidney. Detected in osteoblasts. Detected in the raphe nucleus in the brain, in dorsal root ganglion neurons, the brain stem, cerebellum and spinal cord. Detected in interstitial cells of Cajal in the small intestine. Ligands are bound in a hydrophobic pocket formed by the transmembrane helices. Partial embryonic and perinatal lethality, due to heart ventricle hypoplasia and impaired proliferative capacity of heart myocytes. Mutant mice that survive into adulthood have a decreased heart weight relative to body weight. They display dilated cardiomyopathy with a loss of ventricular mass, due to a reduction in the number and size of cardiomyocytes. The myocardium from mutant mice displays abnormal organization of the contractile elements, with an irregular array of sarcomeric myofibrils and abnormally wide Z bands. In addition, heart muscle mitochondria display structural and functional defects. Mutant mice do not respond to chronic exposure to low oxygen levels by remodeling of their lung arteries, unlike wild- type mice, and as a consequence, do not develop increased right ventricular systolic pressure in response to chronic hypoxia. Adult mutant female mice display reduced bone density that worsens with age. Osteopenia is due to reduced proliferation and delayed differentiation of osteoblasts and reduced calcium incorporation by osteoblasts (PubMed:17846081). In addition, mutant mice display a reduced number of proliferating interstitial cells of Cajal in the myenteric plexus in jejunum muscle, and a reduced number of interstitial cells of Cajal in the deep muscular plexus (PubMed:19941613). Mutant mice also show increased locomotor activity in a novel environment, compared to the wild-type. Unlike the wild-type, they do not respond to the drug 3,4- methylenedioxymethamphetamine with increased locomotion and increased 5-hydroxytryptamine and dopamine levels in the brain (PubMed:18337424). Belongs to the G-protein coupled receptor 1 family. Sequence=CAA78824.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; neural crest cell migration positive regulation of cytokine production positive regulation of endothelial cell proliferation G-protein alpha-subunit binding G-protein coupled receptor internalization heart morphogenesis cardiac muscle hypertrophy G-protein coupled receptor activity G-protein coupled serotonin receptor activity GTPase activator activity nucleoplasm cytoplasm plasma membrane integral component of plasma membrane cellular calcium ion homeostasis smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger phospholipase C-activating G-protein coupled receptor signaling pathway activation of phospholipase C activity protein kinase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating serotonin receptor signaling pathway serotonin receptor signaling pathway chemical synaptic transmission heart development behavior drug binding positive regulation of cell proliferation negative regulation of autophagy positive regulation of phosphatidylinositol biosynthetic process neural crest cell differentiation phosphatidylinositol 3-kinase signaling intestine smooth muscle contraction membrane integral component of membrane phosphorylation calcium-mediated signaling cGMP-mediated signaling cell junction dendrite neurotransmitter receptor activity ion transmembrane transport vasoconstriction response to drug neuron projection neuronal cell body negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAP kinase activity positive regulation of GTPase activity synapse embryonic morphogenesis positive regulation of cytokine secretion regulation of behavior positive regulation of nitric-oxide synthase activity release of sequestered calcium ion into cytosol serotonin binding positive regulation of cell division negative regulation of cell death ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade protein kinase C signaling cellular response to amine stimulus cellular response to temperature stimulus cellular response to serotonin uc007buz.1 uc007buz.2 uc007buz.3 
ENSMUST00000027432.9 Psmd1 ENSMUST00000027432.9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 (from RefSeq NM_027357.2) B2RRP8 ENSMUST00000027432.1 ENSMUST00000027432.2 ENSMUST00000027432.3 ENSMUST00000027432.4 ENSMUST00000027432.5 ENSMUST00000027432.6 ENSMUST00000027432.7 ENSMUST00000027432.8 NM_027357 PSMD1_MOUSE Q3TXS7 uc007buy.1 uc007buy.2 uc007buy.3 In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteasome pathway. The 26S proteasome is a self-compartmentalizing protease comprised of approximately 31 different subunits. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins. Protein degradation by proteasomes is the source of most antigenic peptides presented on MHC class I molecules. This gene encodes a non-ATPase subunit of the 26S proteasome. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK153386.1, AK159750.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD1. Interacts with ADRM1. Interacts with ZFAND1 (By similarity). Belongs to the proteasome subunit S1 family. proteasome complex protein binding nucleus proteasome regulatory particle, base subcomplex proteasome accessory complex enzyme regulator activity ubiquitin protein ligase binding proteasome storage granule regulation of protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of catalytic activity endopeptidase activity uc007buy.1 uc007buy.2 uc007buy.3 
ENSMUST00000027438.8 Ncl ENSMUST00000027438.8 nucleolin (from RefSeq NM_010880.3) ENSMUST00000027438.1 ENSMUST00000027438.2 ENSMUST00000027438.3 ENSMUST00000027438.4 ENSMUST00000027438.5 ENSMUST00000027438.6 ENSMUST00000027438.7 NM_010880 NUCL_MOUSE Nuc P09405 Q548M9 Q61991 Q8BQD8 Q99K50 uc007bvl.1 uc007bvl.2 uc007bvl.3 Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG- 3' repeats more tightly than the telomeric single-stranded DNA 5'- TTAGGG-3' repeats (By similarity). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Component of the SWAP complex that consists of NPM1, NCL/nucleolin, PARP1 and SWAP70 (PubMed:9642267). Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin (By similarity). Interacts with AICDA (PubMed:21518874). Interacts with APTX (By similarity). Interacts with C1QBP (By similarity). Interacts with ERBB4 (By similarity). Interacts (via C-terminus) with FMR1 isoform 6 (via N- terminus) (By similarity). Interacts with GZF1; this interaction is important for nucleolar localization of GZF1 (By similarity). Interacts with NSUN2 (By similarity). Interacts with NVL (PubMed:21474449). Interacts (via N-terminus domain) with SETX (By similarity). Interacts (via RRM1 and C-terminal RRM4/Arg/Gly-rich domains) with TERT; the interaction is important for nucleolar localization of TERT (By similarity). Interacts with WDR46 (By similarity). Interacts with ZFP36 (By similarity). Interacts with LRRC34 (PubMed:24991885). Interacts with RRP1B (By similarity). Interacts with HNRNPU; this interaction occurs during mitosis (By similarity). Interacts with RIOK1; RIOK1 recruits NCL to PRMT5 for symmetrically methylation (By similarity). Interacts with ZBTB7B (PubMed:28784777). Interacts with MDK; this interaction promotes NCL clustering and lateral movements of this complex into lipid rafts leading to MDK internalization (By similarity). Interacts with HDGF (By similarity). Interacts with ALKBH2. P09405; Q9CR42: Ankrd1; NbExp=5; IntAct=EBI-641864, EBI-8308696; P09405; Q9DC51: Gnai3; NbExp=4; IntAct=EBI-641864, EBI-641852; P09405; P63028: Tpt1; NbExp=4; IntAct=EBI-641864, EBI-1635228; Nucleus, nucleolus. Cytoplasm Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in B-cells that have been induced to switch to various Ig isotypes. Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group. Symmetrically methylated by PRMT5. angiogenesis fibrillar center dense fibrillar component nucleic acid binding DNA binding single-stranded DNA binding RNA binding receptor binding calcium ion binding protein binding nucleus nucleoplasm spliceosomal complex nucleolus cytoplasm cell cortex endocytosis protein C-terminus binding cell surface negative regulation of translation positive regulation of tumor necrosis factor production selenocysteine insertion sequence binding cytoplasmic ribonucleoprotein granule rRNA primary transcript binding telomeric DNA binding histone binding identical protein binding negative regulation of apoptotic process laminin binding sequence-specific DNA binding DNA topoisomerase binding positive regulation of transcription from RNA polymerase II promoter positive regulation of mRNA splicing, via spliceosome mRNA 5'-UTR binding cellular response to lipopolysaccharide cellular response to epidermal growth factor stimulus positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter ErbB-4 class receptor binding cellular response to leukemia inhibitory factor ribonucleoprotein complex regulation of rRNA processing positive regulation of interleukin-6 secretion uc007bvl.1 uc007bvl.2 uc007bvl.3 
ENSMUST00000027444.15 Pde6d ENSMUST00000027444.15 phosphodiesterase 6D, cGMP-specific, rod, delta, transcript variant 1 (from RefSeq NM_008801.4) ENSMUST00000027444.1 ENSMUST00000027444.10 ENSMUST00000027444.11 ENSMUST00000027444.12 ENSMUST00000027444.13 ENSMUST00000027444.14 ENSMUST00000027444.2 ENSMUST00000027444.3 ENSMUST00000027444.4 ENSMUST00000027444.5 ENSMUST00000027444.6 ENSMUST00000027444.7 ENSMUST00000027444.8 ENSMUST00000027444.9 NM_008801 Pde6d Q3TDQ8 Q3TDQ8_MOUSE uc007bvq.1 uc007bvq.2 uc007bvq.3 Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate. Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane. Cytoplasm, cytosol Cytoplasmic vesicle membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton, cilium basal body Belongs to the PDE6D/unc-119 family. 3',5'-cyclic-nucleotide phosphodiesterase activity cytoplasm cytosol cytoskeleton visual perception membrane Rab GTPase binding cytoplasmic vesicle membrane cytoplasmic vesicle response to stimulus sensory perception of light stimulus uc007bvq.1 uc007bvq.2 uc007bvq.3 
ENSMUST00000027449.6 Nppc ENSMUST00000027449.6 natriuretic peptide type C (from RefSeq NM_010933.5) ANFC_MOUSE Cnp ENSMUST00000027449.1 ENSMUST00000027449.2 ENSMUST00000027449.3 ENSMUST00000027449.4 ENSMUST00000027449.5 NM_010933 Q61839 uc007bvt.1 uc007bvt.2 uc007bvt.3 uc007bvt.4 This gene encodes a member of the natriuretic peptide family. Natriuretic peptides are involved in the control of blood pressure, extracellular fluid volume and electrolyte homeostasis. The encoded protein also plays a role in sensory neuron bifurcation, and is a critical regulator of endochondral bone growth. The encoded protein is a ligand for the natriuretic peptide receptor B, and is synthesized as a preprohormone which is cleaved to produce a mature peptide. Mutations in this gene are associated with dwarfism resulting from impaired endochondral ossification. [provided by RefSeq, Apr 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036176.1, AK020093.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## [CNP-22]: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (PubMed:11259675). May also be vasoactive and natriuretic (By similarity). Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:12890708). Binds the clearance receptor NPR3 (By similarity). Secreted. [CNP-22]: Degraded by IDE (in vitro). Mice are viable perinatally but less than half survive postnatally due to skeletal abnormalities. They display severe dwarfism which is the consequence of a defect in endochondral ossification. Belongs to the natriuretic peptide family. ossification response to hypoxia growth plate cartilage chondrocyte differentiation growth plate cartilage chondrocyte proliferation receptor binding hormone activity neuropeptide hormone activity extracellular region extracellular space cGMP biosynthetic process protein folding receptor guanylyl cyclase signaling pathway negative regulation of cell proliferation post-embryonic development positive regulation of cGMP-mediated signaling cGMP-mediated signaling reproductive process secretory granule negative regulation of collagen biosynthetic process macromolecular complex regulation of multicellular organism growth response to drug response to ethanol positive regulation of osteoblast differentiation animal organ development regulation of smooth muscle cell proliferation hormone receptor binding negative regulation of meiotic cell cycle negative regulation of oocyte maturation negative regulation of DNA biosynthetic process uc007bvt.1 uc007bvt.2 uc007bvt.3 uc007bvt.4 
ENSMUST00000027451.13 Epha4 ENSMUST00000027451.13 Eph receptor A4 (from RefSeq NM_007936.3) ENSMUST00000027451.1 ENSMUST00000027451.10 ENSMUST00000027451.11 ENSMUST00000027451.12 ENSMUST00000027451.2 ENSMUST00000027451.3 ENSMUST00000027451.4 ENSMUST00000027451.5 ENSMUST00000027451.6 ENSMUST00000027451.7 ENSMUST00000027451.8 ENSMUST00000027451.9 EPHA4_MOUSE NM_007936 Q03137 Q80VZ2 Sek Sek1 uc007bpz.1 uc007bpz.2 Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity (PubMed:17719550). Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections (PubMed:9789074, PubMed:17719550, PubMed:17785183). May also control the segregation of motor and sensory axons during neuromuscular circuit developmen (PubMed:18403711). In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis (PubMed:17143272). In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation (PubMed:15537875, PubMed:16802330). Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium (PubMed:16818734). During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (PubMed:30639848). Phosphorylates CAPRIN1, promoting CAPRIN1- dependent formation of a membraneless compartment (PubMed:31439799). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence= Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (phosphorylated at position Tyr-602) with FYN. Interacts (via PDZ motif) with SIPA1L1 (via PDZ domain); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with CDK5, CDK5R1 and NGEF; upon activation by EFNA1 induces NGEF phosphorylation by the kinase CDK5. Interacts with CHN1; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation. Forms a ternary complex composed of ADAM10, CADH1 and EPHA4; within the complex, CADH1 is cleaved by ADAM10 which disrupts adherens junctions (PubMed:30639848). Q03137; Q91V57-1: Chn1; NbExp=2; IntAct=EBI-1539152, EBI-1539203; Q03137; P52800: Efnb2; NbExp=2; IntAct=EBI-1539152, EBI-1032676; Q03137; Q03145: Epha2; NbExp=3; IntAct=EBI-1539152, EBI-529701; Q03137; Q03137: Epha4; NbExp=2; IntAct=EBI-1539152, EBI-1539152; Q03137; P54763: Ephb2; NbExp=3; IntAct=EBI-1539152, EBI-537711; Q03137; Q921Q7: Rin1; NbExp=2; IntAct=EBI-1539152, EBI-15724937; Q03137; O95292: VAPB; Xeno; NbExp=2; IntAct=EBI-1539152, EBI-1188298; Cell membrane ; Single-pass type I membrane protein Cell projection, axon Cell projection, dendrite Postsynaptic density membrane Early endosome Cell junction, adherens junction Note=Clustered upon activation and targeted to early endosome. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q03137-1; Sequence=Displayed; Name=Short; IsoId=Q03137-2; Sequence=VSP_002998; Expressed in inner and outer pillar cells of the organ of Corti (at protein level) (PubMed:30639848). Highest expression in the adult brain and retina and also detectable in kidney, lung, skeletal muscle and thymus. Not detected in heart and liver. Expressed in myogenic progenitor cells (PubMed:27446912). Found in both the 10-day embryonic brain and body tissues. In the embryonic brain, expressed in the developing cortex of the telencephalon and major cortical tracts. Also expressed in the hippocampus, fornix and striatal cells and tracts. In the diencephalon, strongly expressed in thalamus, hypothalamus and thalamo-cortical projection. Also expressed in red nuclei of the mesencephalon and in the cerebellum. In the spinal cord, persistent expression occurs in the dorsal funiculus and ventral gray matter. In myogenic progenitor cells, highly expressed at 11.5 dpc and ceases its expression at the late fetal stage (17.5 dpc) (PubMed:27446912). The protein kinase domain mediates interaction with NGEF. Mice are viable and fertile but display a loss of coordination of limb movement associated with disruptions of cortico- spinal tract. They also display altered development of the thymic epithelium which leads to a defective T-cells development. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity GPI-linked ephrin receptor activity transmembrane-ephrin receptor activity protein binding ATP binding cytoplasm mitochondrial outer membrane endosome early endosome endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane adherens junction protein phosphorylation cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development axon guidance adult walking behavior motor neuron axon guidance glial cell migration cell surface negative regulation of neuron projection development postsynaptic density membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation corticospinal tract morphogenesis cell junction filopodium axon dendrite neuromuscular junction early endosome membrane PH domain binding identical protein binding cell projection neuron projection regulation of GTPase activity dendritic spine dendritic shaft perikaryon receptor complex positive regulation of JUN kinase activity axon terminus axonal growth cone cell body synapse postsynaptic membrane protein autophosphorylation ephrin receptor binding ephrin receptor signaling pathway negative regulation of axon regeneration regulation of astrocyte differentiation regulation of axonogenesis positive regulation of dendrite morphogenesis protein stabilization regulation of dendritic spine morphogenesis positive regulation of protein tyrosine kinase activity nephric duct morphogenesis cochlea development fasciculation of sensory neuron axon fasciculation of motor neuron axon DH domain binding neuron projection guidance synapse disassembly glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane negative regulation of long-term synaptic potentiation positive regulation of beta-amyloid formation positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of proteolysis involved in cellular protein catabolic process cellular response to beta-amyloid regulation of modification of synaptic structure protein tyrosine kinase binding positive regulation of Rho guanyl-nucleotide exchange factor activity uc007bpz.1 uc007bpz.2 
ENSMUST00000027464.9 Mrpl44 ENSMUST00000027464.9 mitochondrial ribosomal protein L44 (from RefSeq NM_001081210.1) ENSMUST00000027464.1 ENSMUST00000027464.2 ENSMUST00000027464.3 ENSMUST00000027464.4 ENSMUST00000027464.5 ENSMUST00000027464.6 ENSMUST00000027464.7 ENSMUST00000027464.8 NM_001081210 Q3U0J0 Q8VE61 Q9CY73 RM44_MOUSE uc007bqy.1 uc007bqy.2 Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CY73-1; Sequence=Displayed; Name=2; IsoId=Q9CY73-2; Sequence=VSP_014126, VSP_014127; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily. RNA binding double-stranded RNA binding nuclease activity endonuclease activity ribonuclease III activity nucleus mitochondrion mitochondrial large ribosomal subunit ribosome plasma membrane RNA processing hydrolase activity production of siRNA involved in RNA interference primary miRNA processing pre-miRNA processing mitochondrial translational elongation nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc007bqy.1 uc007bqy.2 
ENSMUST00000027467.11 Serpine2 ENSMUST00000027467.11 serine (or cysteine) peptidase inhibitor, clade E, member 2 (from RefSeq NM_009255.4) ENSMUST00000027467.1 ENSMUST00000027467.10 ENSMUST00000027467.2 ENSMUST00000027467.3 ENSMUST00000027467.4 ENSMUST00000027467.5 ENSMUST00000027467.6 ENSMUST00000027467.7 ENSMUST00000027467.8 ENSMUST00000027467.9 NM_009255 Q543R5 Q543R5_MOUSE Serpine2 uc007bqz.1 uc007bqz.2 uc007bqz.3 uc007bqz.4 Belongs to the serpin family. serine-type endopeptidase inhibitor activity receptor binding glycosaminoglycan binding extracellular region extracellular space cytosol heparin binding negative regulation of plasminogen activation negative regulation of endopeptidase activity negative regulation of blood coagulation platelet alpha granule extrinsic component of external side of plasma membrane negative regulation of proteolysis positive regulation of astrocyte differentiation uc007bqz.1 uc007bqz.2 uc007bqz.3 uc007bqz.4 
ENSMUST00000027470.14 Chrng ENSMUST00000027470.14 cholinergic receptor, nicotinic, gamma polypeptide, transcript variant 1 (from RefSeq NM_009604.4) Chrng ENSMUST00000027470.1 ENSMUST00000027470.10 ENSMUST00000027470.11 ENSMUST00000027470.12 ENSMUST00000027470.13 ENSMUST00000027470.2 ENSMUST00000027470.3 ENSMUST00000027470.4 ENSMUST00000027470.5 ENSMUST00000027470.6 ENSMUST00000027470.7 ENSMUST00000027470.8 ENSMUST00000027470.9 F8VQK4 F8VQK4_MOUSE NM_009604 uc007bwh.1 uc007bwh.2 uc007bwh.3 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub- subfamily. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane ion transport membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction ion transmembrane transport synapse postsynaptic membrane regulation of postsynaptic membrane potential excitatory postsynaptic potential uc007bwh.1 uc007bwh.2 uc007bwh.3 
ENSMUST00000027472.7 Efhd1 ENSMUST00000027472.7 EF hand domain containing 1, transcript variant 1 (from RefSeq NM_028889.3) EFHD1_MOUSE ENSMUST00000027472.1 ENSMUST00000027472.2 ENSMUST00000027472.3 ENSMUST00000027472.4 ENSMUST00000027472.5 ENSMUST00000027472.6 NM_028889 Q543U4 Q9D4J1 Sws2 uc007bwo.1 uc007bwo.2 uc007bwo.3 Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (By similarity). May play a role in neuronal differentiation (PubMed:16336229). Mitochondrion inner membrane Widely expressed (PubMed:16336229). Highest expression in testis, followed by ovary, kidney, cerebrum, cerebellum, heart, liver, and spleen (PubMed:12270117). In the cerebrum and cerebellum, undetectable at embryonic stages, expression increases after birth up to adult stage (PubMed:12270117). In adult CNS, detected in neurons of the cerebellum, cerebrum and hippocampus formation, including dentate gyrus and Cornu Ammonis, but not in the white matter (PubMed:12270117). In the testis, expressed in spermatocytes, but not in spermatogonia nor in interstitial cells (PubMed:12270117). In ovary, found predominantly in mural granulosa cells and those of the cumulus oophorus (PubMed:12270117). In kidney, expressed in collecting ducts, but not in glomeruli (PubMed:12270117). Not detected in skeletal muscle (PubMed:12270117). In the cerebral cortex, at birth, confined in the Purkinje cell layer (PCL) and in cerebellar nuclei. Not detected in the external germinal layer (EGL). At P5 and P10, predominantly found in the PCL and internal germinal layer (IGL). Not detected in the EGL. At P10 and P20, up-regulated. At P20, expression similar to that of the adult cerebellum. calcium ion binding mitochondrion mitochondrial inner membrane membrane neuron projection development metal ion binding regulation of cellular hyperosmotic salinity response uc007bwo.1 uc007bwo.2 uc007bwo.3 
ENSMUST00000027475.15 Gigyf2 ENSMUST00000027475.15 GRB10 interacting GYF protein 2, transcript variant 1 (from RefSeq NM_146112.4) ENSMUST00000027475.1 ENSMUST00000027475.10 ENSMUST00000027475.11 ENSMUST00000027475.12 ENSMUST00000027475.13 ENSMUST00000027475.14 ENSMUST00000027475.2 ENSMUST00000027475.3 ENSMUST00000027475.4 ENSMUST00000027475.5 ENSMUST00000027475.6 ENSMUST00000027475.7 ENSMUST00000027475.8 ENSMUST00000027475.9 GGYF2_MOUSE Gigyf2 Kiaa0642 NM_146112 Perq2 Q0VGQ7 Q3UNS2 Q63ZU9 Q6Y7W8 Q80TV1 Q8K0R0 Q8R0A3 Tnrc15 uc007bwt.1 uc007bwt.2 uc007bwt.3 uc007bwt.4 Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:26763119). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:26763119). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome- associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC- mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (By similarity). Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598 (PubMed:26763119). Interacts (via the 4EHP- binding motif) with EIF4E2; the interaction is direct (By similarity). Interacts with ZFP36/TTP (via P-P-P-P-G repeats); the interaction is direct (PubMed:26763119). Interacts with GRB10 (PubMed:12771153). Interacts (via DDX6 motif) with DDX6 (via RecA-like domain 2) (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6Y7W8-1; Sequence=Displayed; Name=2; IsoId=Q6Y7W8-2; Sequence=VSP_022247; Expressed in heart, liver, kidney and brain as well as in testis (PubMed:12771153). Widely expressed in embryonic tissues, including strong expression in the central nervous system. Mice undergo normal embryonic development, but fail to feed and die within the first 2 postnatal days. Heterozygous mice survive to adulthood with no evident metabolic or growth defects. At 12-15 months of age, heterozygous mice show motor dysfunction associated with histopathologic evidence of neurodegeneration and rare intracytoplasmic Lewy body-like inclusions in spinal anterior horn motor neurons. Belongs to the GIGYF family. protein binding cytoplasm endosome endoplasmic reticulum Golgi apparatus cytosol feeding behavior adult locomotory behavior post-embryonic development cytoplasmic stress granule integral component of membrane posttranscriptional gene silencing negative regulation of translation spinal cord motor neuron differentiation mitotic G1 DNA damage checkpoint vesicle macromolecular complex multicellular organism growth perikaryon cellular protein metabolic process insulin-like growth factor receptor signaling pathway homeostasis of number of cells within a tissue musculoskeletal movement neuromuscular process controlling balance mRNA destabilization proline-rich region binding proximal dendrite uc007bwt.1 uc007bwt.2 uc007bwt.3 uc007bwt.4 
ENSMUST00000027476.6 Snorc ENSMUST00000027476.6 secondary ossification center associated regulator of chondrocyte maturation, transcript variant 1 (from RefSeq NM_028473.3) ENSMUST00000027476.1 ENSMUST00000027476.2 ENSMUST00000027476.3 ENSMUST00000027476.4 ENSMUST00000027476.5 NM_028473 Q08EF5 Q9CXL7 SNORC_MOUSE Snorc uc007bww.1 uc007bww.2 uc007bww.3 uc007bww.4 Plays a role in the regulation of chondrocyte maturation and postnatal endochondral ossification. May inhibit cell growth stimulation induced by FGF2. Interacts (via the extracellular domain) with FGF2. Membrane ; Single- pass membrane protein Cytoplasm Secreted, extracellular space, extracellular matrix te=Appears as reticular-like structures throughout the cytoplasm and adjacent to the plasma membrane (PubMed:21624478). In proliferation and hypertrophic chondrocytes, detected intracellulary and in the pericellular extracellular matrix. In primary spongiosa, detected only in the extracellular matrix (PubMed:28323137). Expressed only in cartilage, including nasal, knee epiphyseal and rib tissues (PubMed:21624478). In proliferation and hypertrophic chondrocytes, detected intracellulary and in the pericellular extracellular matrix. In primary spongiosa, detected only in the extracellular matrix (PubMed:28323137). At 16.5 dpc and 18.5 dpc expression is cartilage specific. In tracheal and nasal cartilage, expression is seen throughout all chondrocytes at a similar intensity while in other cartilage tissues undergoing endochondral ossification, intensity is strongest in proliferating and prehypertrophic stages. In knee epiphyseal cartilage, expression is detected from 12.5 dpc onwards, with significant up-regulation at 16.5 dpc and again at postnatal day 5. Expressed at least until 10 months of age. In chondrocytes, induced by BMP2. Mutants are born with the expected Mendelian frequency and show no differences in fertility, gross morphology or body weight (PubMed:28323137). Secondary ossification centers in knee epiphyses are smaller and growth plate maturation is disturbed, but total bone length is normal. Central proliferative and hypertrophic zones are enlarged with higher extracellular matrix volume and rounded chondrocyte morphology at postnatal days P10 and P22 (PubMed:28323137). protein binding extracellular region cytoplasm membrane integral component of membrane cartilage development cell periphery uc007bww.1 uc007bww.2 uc007bww.3 uc007bww.4 
ENSMUST00000027477.15 Ngef ENSMUST00000027477.15 neuronal guanine nucleotide exchange factor, transcript variant 2 (from RefSeq NM_019867.2) ENSMUST00000027477.1 ENSMUST00000027477.10 ENSMUST00000027477.11 ENSMUST00000027477.12 ENSMUST00000027477.13 ENSMUST00000027477.14 ENSMUST00000027477.2 ENSMUST00000027477.3 ENSMUST00000027477.4 ENSMUST00000027477.5 ENSMUST00000027477.6 ENSMUST00000027477.7 ENSMUST00000027477.8 ENSMUST00000027477.9 NGEF_MOUSE NM_019867 Q8CHT1 Q8R204 Q923H2 Q9JHT9 uc007bwx.1 uc007bwx.2 uc007bwx.3 uc007bwx.4 Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension. Interacts with CDK5R1 and EPHA4; activated by EPHA4 through the CDK5 kinase. Cytoplasm Membrane Cell projection, growth cone Note=Associated with membranes. Localizes to axonal growth cones (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CHT1-1; Sequence=Displayed; Name=2; IsoId=Q8CHT1-2; Sequence=VSP_020262, VSP_020263; Highly expressed in brain and to a lower extent in eye. Highly expressed in 7 dpc and to a lower extent in 11 dpc, 15 dpc and 17 dpc embryos. Expressed at 16.5 dpc in the lateral regions of the cortex. The DH domain and the PH domain are both required to mediate interaction with EPHA4. Src-dependent phosphorylation at Tyr-177 upon EPHA4 activation increases the guanine exchange factor activity toward RHOA. Phosphorylation by CDK5 upon EPHA4 activation by EFNA1 may regulate dendritic spine morphogenesis. Sequence=AAH22680.1; Type=Erroneous initiation; Evidence=; Sequence=CAC00698.1; Type=Frameshift; Evidence=; guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding cytoplasm cytosol multicellular organism development nervous system development cellular process membrane cell differentiation growth cone regulation of Rho protein signal transduction cell projection regulation of GTPase activity ephrin receptor binding ephrin receptor signaling pathway negative regulation of dendritic spine morphogenesis synapse disassembly glutamatergic synapse uc007bwx.1 uc007bwx.2 uc007bwx.3 uc007bwx.4 
ENSMUST00000027478.7 Ndufa10 ENSMUST00000027478.7 NADH:ubiquinone oxidoreductase subunit A10 (from RefSeq NM_024197.1) ENSMUST00000027478.1 ENSMUST00000027478.2 ENSMUST00000027478.3 ENSMUST00000027478.4 ENSMUST00000027478.5 ENSMUST00000027478.6 NDUAA_MOUSE NM_024197 Q3UKK0 Q8BL57 Q99LC3 Q9CW21 uc007cbh.1 uc007cbh.2 uc007cbh.3 uc007cbh.4 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.; Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Mitochondrion matrix Phosphorylation at Ser-250 by PINK1 is required for the binding and/or reduction of the complex I substrate ubiquinone. Acetylation of Lys-242 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the complex I NDUFA10 subunit family. Sequence=BAB23961.2; Type=Erroneous initiation; Evidence=; cytoplasm mitochondrion mitochondrial respiratory chain complex I mitochondrial matrix mitochondrial electron transport, NADH to ubiquinone NADH dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex I assembly myelin sheath oxidation-reduction process respiratory chain uc007cbh.1 uc007cbh.2 uc007cbh.3 uc007cbh.4 
ENSMUST00000027487.15 Rnpepl1 ENSMUST00000027487.15 arginyl aminopeptidase (aminopeptidase B)-like 1 (from RefSeq NM_181405.4) ENSMUST00000027487.1 ENSMUST00000027487.10 ENSMUST00000027487.11 ENSMUST00000027487.12 ENSMUST00000027487.13 ENSMUST00000027487.14 ENSMUST00000027487.2 ENSMUST00000027487.3 ENSMUST00000027487.4 ENSMUST00000027487.5 ENSMUST00000027487.6 ENSMUST00000027487.7 ENSMUST00000027487.8 ENSMUST00000027487.9 G5E872 NM_181405 RNPL1_MOUSE Rnpepl1 uc007cbw.1 uc007cbw.2 uc007cbw.3 uc007cbw.4 Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine. Reaction=Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; EC=3.4.11.18; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Belongs to the peptidase M1 family. aminopeptidase activity proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding metalloaminopeptidase activity uc007cbw.1 uc007cbw.2 uc007cbw.3 uc007cbw.4 
ENSMUST00000027488.11 Capn10 ENSMUST00000027488.11 calpain 10 (from RefSeq NM_011796.2) CAN10_MOUSE Capn8 ENSMUST00000027488.1 ENSMUST00000027488.10 ENSMUST00000027488.2 ENSMUST00000027488.3 ENSMUST00000027488.4 ENSMUST00000027488.5 ENSMUST00000027488.6 ENSMUST00000027488.7 ENSMUST00000027488.8 ENSMUST00000027488.9 NM_011796 Q99J13 Q9ESK3 Q9WVF0 uc007cby.1 uc007cby.2 uc007cby.3 Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin- stimulated glucose uptake (By similarity). Belongs to the peptidase C2 family. SNARE binding mitophagy calcium-dependent cysteine-type endopeptidase activity nucleus cytoplasm mitochondrion mitochondrial outer membrane mitochondrial inner membrane mitochondrial intermembrane space mitochondrial matrix cytosol cytoskeleton plasma membrane cell cortex proteolysis mitochondrion organization aging cytoskeletal protein binding peptidase activity cysteine-type peptidase activity hydrolase activity actin cytoskeleton reorganization response to nutrient levels positive regulation of insulin secretion positive regulation of intracellular transport cellular response to insulin stimulus positive regulation of apoptotic process intracellular membrane-bounded organelle positive regulation of glucose import type B pancreatic cell apoptotic process positive regulation of type B pancreatic cell apoptotic process uc007cby.1 uc007cby.2 uc007cby.3 
ENSMUST00000027491.7 Agxt ENSMUST00000027491.7 alanine-glyoxylate aminotransferase, transcript variant 1 (from RefSeq NM_016702.3) AGT1_MOUSE Agxt Agxt1 ENSMUST00000027491.1 ENSMUST00000027491.2 ENSMUST00000027491.3 ENSMUST00000027491.4 ENSMUST00000027491.5 ENSMUST00000027491.6 NM_016702 O35423 Q8R128 uc007cdi.1 uc007cdi.2 uc007cdi.3 [Isoform Peroxisomal]: Catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification. [Isoform Mitochondrial]: Catalyzes the transamination between L-serine and pyruvate and weakly contributes to gluconeogenesis from the L-serine metabolism. [Isoform Mitochondrial]: Reaction=L-serine + pyruvate = 3-hydroxypyruvate + L-alanine; Xref=Rhea:RHEA:22852, ChEBI:CHEBI:15361, ChEBI:CHEBI:17180, ChEBI:CHEBI:33384, ChEBI:CHEBI:57972; EC=2.6.1.51; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22853; Evidence=; [Isoform Peroxisomal]: Reaction=glyoxylate + L-alanine = glycine + pyruvate; Xref=Rhea:RHEA:24248, ChEBI:CHEBI:15361, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:57972; EC=2.6.1.44; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24249; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Homodimer. [Isoform Peroxisomal]: Peroxisome [Isoform Mitochondrial]: Mitochondrion matrix Event=Alternative initiation; Named isoforms=2; Name=Mitochondrial ; IsoId=O35423-1; Sequence=Displayed; Name=Peroxisomal ; IsoId=O35423-2; Sequence=VSP_018644; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. The intracellular compartmentalization of AGTX in mammalian hepatocytes is species dependent. In human and rabbit, AGTX is peroxisomal. In new world monkeys (marmoset) and rodents (rat and mouse), it is distributed approximately evenly between peroxisomes and mitochondria. In carnivores, like cat, the great majority of the enzyme is mitochondrial with only a small proportion being peroxisomal. catalytic activity serine-pyruvate transaminase activity mitochondrion mitochondrial matrix peroxisome peroxisomal matrix Notch signaling pathway alanine-glyoxylate transaminase activity transaminase activity glyoxylate catabolic process amino acid binding transferase activity glycine biosynthetic process, by transamination of glyoxylate L-cysteine catabolic process pyridoxal phosphate binding identical protein binding protein homodimerization activity L-alanine catabolic process pyruvate biosynthetic process intracellular membrane-bounded organelle protein self-association glyoxylate metabolic process oxalic acid secretion response to glucocorticoid response to cAMP uc007cdi.1 uc007cdi.2 uc007cdi.3 
ENSMUST00000027492.14 Mterf4 ENSMUST00000027492.14 mitochondrial transcription termination factor 4, transcript variant 1 (from RefSeq NM_178051.4) ENSMUST00000027492.1 ENSMUST00000027492.10 ENSMUST00000027492.11 ENSMUST00000027492.12 ENSMUST00000027492.13 ENSMUST00000027492.2 ENSMUST00000027492.3 ENSMUST00000027492.4 ENSMUST00000027492.5 ENSMUST00000027492.6 ENSMUST00000027492.7 ENSMUST00000027492.8 ENSMUST00000027492.9 HSPC096 MTEF4_MOUSE Mterfd2 NM_178051 Q8BVN4 Q99LQ0 uc007cdo.1 uc007cdo.2 uc007cdo.3 uc007cdo.4 Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S (By similarity). Targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit. Heterodimer with NSUN4; this interaction may be required for NSUN4 recruitment to the mitochondrial large ribosomal subunit. Mitochondrion Widely expressed, with highest levels in liver, followed by testis, kidney and brain. The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction. Ablation of the gene is not viable. At 8.5 dpc, mutant homozygous embryos exhibit much reduced size, lack of heart and no optic disks. Conditional knockout in heart leads to severe mitochondrial cardiomyopathy. Premature death occurs at about 21 weeks and decreased body weight is observed from 15 weeks until death. Belongs to the mTERF family. Sequence=AAH02280.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH55877.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; double-stranded DNA binding RNA binding mitochondrion mitochondrial large ribosomal subunit cytosol regulation of transcription, DNA-templated rRNA processing transcription from mitochondrial promoter protein targeting to mitochondrion heart development rRNA binding mitochondrial translation ribosome assembly camera-type eye development mitochondrial ribosome assembly uc007cdo.1 uc007cdo.2 uc007cdo.3 uc007cdo.4 
ENSMUST00000027493.4 Pask ENSMUST00000027493.4 PAS domain containing serine/threonine kinase, transcript variant 1 (from RefSeq NM_080850.3) E9QM58 ENSMUST00000027493.1 ENSMUST00000027493.2 ENSMUST00000027493.3 Kiaa0135 NM_080850 PASK_MOUSE Q8CEE6 Q91YD8 uc007cdt.1 uc007cdt.2 uc007cdt.3 uc007cdt.4 Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Protein kinase activity is inhibited by the first PAS domain: binding of an unidentified ligand desinhibits the protein kinase activity. May be activated by autophosphorylation on Thr-1221 and Thr-1225. Autophosphorylation is enhanced upon phosphatidylinositol monophosphate (phosphatidylinositol 4-phosphate) binding and inhibited upon phosphatidylinositol bi- and tri-phosphate binding. In contrast, phosphorylation of target proteins is inhibited upon all phosphatidylinositol-binding (phosphatidylinositol mono- bi- and tri- phosphate) (By similarity). Cytoplasm Nucleus Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails. Ubiquitously expressed. Strongly up-regulated in postmeiotic germ cells during spermatogenesis. The protein kinase domain mediates binding to phosphatidylinositol. Autophosphorylated on Thr-1221 and Thr-1225. Autophosphorylation is activated by phospholipids (By similarity). No visible phenotype under normal conditions: mice show normal development, growth and reproduction. Fertility and sperm production and motility are not affected in males. Under high-fat diet, mice seem to be protected from deleterious effects, including obesity, liver triglyceride accumulation and insulin resistance (PubMed:17878307). In contrast, the lean phenotype appears only after feeding a high-fat diet: under normal chow diet, body weight, fat composition, oxygen consumption are not distinguishable from wild-type mice (PubMed:17192472). The only difference between these 2 experiments is that mice were backcrossed into C57BL/6 5 times in the first study (PubMed:17878307), while the 10th backcross was used in the second study (PubMed:17192472). Female but not male mice show an increased ventilatory response to acute hypoxia and fail to reach ventilatory acclimatization to chronic hypoxia. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm cytosol protein phosphorylation lipid binding kinase activity phosphorylation transferase activity phosphatidylinositol binding intracellular signal transduction regulation of respiratory gaseous exchange negative regulation of glycogen biosynthetic process protein autophosphorylation regulation of glucagon secretion energy homeostasis uc007cdt.1 uc007cdt.2 uc007cdt.3 uc007cdt.4 
ENSMUST00000027494.11 Ppp1r7 ENSMUST00000027494.11 protein phosphatase 1, regulatory subunit 7 (from RefSeq NM_023200.3) ENSMUST00000027494.1 ENSMUST00000027494.10 ENSMUST00000027494.2 ENSMUST00000027494.3 ENSMUST00000027494.4 ENSMUST00000027494.5 ENSMUST00000027494.6 ENSMUST00000027494.7 ENSMUST00000027494.8 ENSMUST00000027494.9 NM_023200 PP1R7_MOUSE Q3UM45 Q9CV31 Q9Z105 Sds22 uc007cdv.1 uc007cdv.2 uc007cdv.3 Regulatory subunit of protein phosphatase 1. Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G. Q3UM45; P62137: Ppp1ca; NbExp=3; IntAct=EBI-8318179, EBI-357187; Nucleus Widely expressed with high level in testis. Expression increases during puberty. Expressed in spermatids and probably also in spermatozoa. Belongs to the SDS22 family. Sequence=BAB26554.1; Type=Frameshift; Evidence=; protein binding nucleus chromosome chromosome segregation positive regulation of protein dephosphorylation uc007cdv.1 uc007cdv.2 uc007cdv.3 
ENSMUST00000027495.15 Septin2 ENSMUST00000027495.15 septin 2, transcript variant 2 (from RefSeq NM_010891.2) B2RRZ2 ENSMUST00000027495.1 ENSMUST00000027495.10 ENSMUST00000027495.11 ENSMUST00000027495.12 ENSMUST00000027495.13 ENSMUST00000027495.14 ENSMUST00000027495.2 ENSMUST00000027495.3 ENSMUST00000027495.4 ENSMUST00000027495.5 ENSMUST00000027495.6 ENSMUST00000027495.7 ENSMUST00000027495.8 ENSMUST00000027495.9 NM_010891 Nedd5 P42208 Q3U9Y5 SEPT2_MOUSE Sept2 Septin2 uc007cea.1 uc007cea.2 uc007cea.3 uc007cea.4 uc007cea.5 Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar- shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements (By similarity). In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules (By similarity). GTPase activity is required for filament formation (By similarity). Septin filaments are assembled from asymmetrical heterotrimers, composed of SEPTIN2, SEPTIN6 and SEPTIN7 that associate head-to-head to form a hexameric unit (By similarity). Interaction between SEPTIN2 and SEPTIN7 seems indirect (By similarity). Interacts also with SEPTIN9 and SEPTIN5 (PubMed:11739749). Interaction with SEPTIN4 not detected (PubMed:11739749). Component of a septin core octameric complex consisting of SEPTIN12, SEPTIN7, SEPTIN6 and SEPTIN2 or SEPTIN4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6- 7-12 and located in the sperm annulus (By similarity). Interacts with MAP4 (By similarity). Interacts with DZIP1L (By similarity). Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle Chromosome, centromere, kinetochore Cleavage furrow Midbody Cytoplasm, cell cortex Cell projection, cilium membrane. Cell projection, cilium, flagellum Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle (By similarity). In interphase and postmitotic cells, localized to fibrous or granular structures, depending on the growth state of the cell. Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes. Found in the sperm annulus. Widely expressed. Expressed at 17 dpc in the brain with levels remaining relatively stable up to adulthood (at protein level). Coordinated expression with SEPTIN6 and SEPTIN7. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. exocyst nucleotide binding chromosome, centromeric region kinetochore condensed chromosome kinetochore regulation of L-glutamate transport GTPase activity protein binding GTP binding nucleus chromosome cytoplasm spindle actomyosin contractile ring cytoskeleton spindle microtubule plasma membrane cilium axoneme cell cortex septin ring cell cycle smoothened signaling pathway spermatogenesis cell surface actin cytoskeleton microtubule cytoskeleton membrane cell differentiation enzyme regulator activity midbody septin complex neuron projection development motile cilium cleavage furrow photoreceptor connecting cilium regulation of protein localization ciliary transition zone identical protein binding cell projection myelin sheath synapse perinuclear region of cytoplasm regulation of catalytic activity protein polymerization cell division binding, bridging ciliary membrane cilium assembly cytoskeleton-dependent cytokinesis sperm annulus non-motile cilium uc007cea.1 uc007cea.2 uc007cea.3 uc007cea.4 uc007cea.5 
ENSMUST00000027498.14 Stk25 ENSMUST00000027498.14 serine/threonine kinase 25 (yeast) (from RefSeq NM_021537.3) ENSMUST00000027498.1 ENSMUST00000027498.10 ENSMUST00000027498.11 ENSMUST00000027498.12 ENSMUST00000027498.13 ENSMUST00000027498.2 ENSMUST00000027498.3 ENSMUST00000027498.4 ENSMUST00000027498.5 ENSMUST00000027498.6 ENSMUST00000027498.7 ENSMUST00000027498.8 ENSMUST00000027498.9 NM_021537 Q6IR17 Q9Z2W1 STK25_MOUSE Sok1 uc007ced.1 uc007ced.2 uc007ced.3 Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-174, possibly as a consequence of stabilization of dimer formation. The C-terminal non-catalytic region inhibits the kinase activity (By similarity). Homodimer. Interacts with CTTNBP2NL. Cytoplasm Golgi apparatus Note=Localizes to the Golgi apparatus. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Golgi membrane nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm Golgi apparatus protein phosphorylation establishment or maintenance of cell polarity kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation activation of protein kinase activity positive regulation of stress-activated MAPK cascade intrinsic apoptotic signaling pathway in response to hydrogen peroxide response to hydrogen peroxide protein homodimerization activity protein autophosphorylation metal ion binding positive regulation of axonogenesis Golgi localization establishment of Golgi localization Golgi reassembly uc007ced.1 uc007ced.2 uc007ced.3 
ENSMUST00000027499.13 Bok ENSMUST00000027499.13 BCL2-related ovarian killer (from RefSeq NM_016778.3) Bok ENSMUST00000027499.1 ENSMUST00000027499.10 ENSMUST00000027499.11 ENSMUST00000027499.12 ENSMUST00000027499.2 ENSMUST00000027499.3 ENSMUST00000027499.4 ENSMUST00000027499.5 ENSMUST00000027499.6 ENSMUST00000027499.7 ENSMUST00000027499.8 ENSMUST00000027499.9 NM_016778 Q3TH93 Q3TH93_MOUSE uc007cee.1 uc007cee.2 uc007cee.3 uc007cee.4 Belongs to the Bcl-2 family. release of cytochrome c from mitochondria nucleus cytoplasm mitochondrion mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process brain development cell proliferation male gonad development regulation of autophagy mitochondrial membrane regulation of apoptotic process positive regulation of apoptotic process protein heterodimerization activity protein dimerization activity oligodendrocyte differentiation BH domain binding intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of execution phase of apoptosis regulation of chorionic trophoblast cell proliferation regulation of granulosa cell apoptotic process uc007cee.1 uc007cee.2 uc007cee.3 uc007cee.4 
ENSMUST00000027502.16 Atg4b ENSMUST00000027502.16 autophagy related 4B, cysteine peptidase, transcript variant 1 (from RefSeq NM_174874.4) A0A0R4J065 A0A0R4J065_MOUSE Atg4b ENSMUST00000027502.1 ENSMUST00000027502.10 ENSMUST00000027502.11 ENSMUST00000027502.12 ENSMUST00000027502.13 ENSMUST00000027502.14 ENSMUST00000027502.15 ENSMUST00000027502.2 ENSMUST00000027502.3 ENSMUST00000027502.4 ENSMUST00000027502.5 ENSMUST00000027502.6 ENSMUST00000027502.7 ENSMUST00000027502.8 ENSMUST00000027502.9 NM_174874 uc007cej.1 uc007cej.2 uc007cej.3 Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. Reaction=[protein]-C-terminal L-amino acid-glycyl- phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid- glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:67548, Rhea:RHEA-COMP:17323, Rhea:RHEA-COMP:17324, ChEBI:CHEBI:15377, ChEBI:CHEBI:64612, ChEBI:CHEBI:172940, ChEBI:CHEBI:172941; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67549; Evidence=; Reaction=[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn- glycero-3-phospho-L-serine; Xref=Rhea:RHEA:67576, Rhea:RHEA- COMP:17324, Rhea:RHEA-COMP:17326, ChEBI:CHEBI:15377, ChEBI:CHEBI:57262, ChEBI:CHEBI:172940, ChEBI:CHEBI:172942; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67577; Evidence=; Cytoplasm, cytosol Cytoplasmic vesicle, autophagosome Endoplasmic reticulum Mitochondrion Belongs to the peptidase C54 family. endopeptidase activity cysteine-type endopeptidase activity cytoplasm proteolysis autophagy peptidase activity cysteine-type peptidase activity protein transport hydrolase activity positive regulation of protein catabolic process protein delipidation uc007cej.1 uc007cej.2 uc007cej.3 
ENSMUST00000027503.14 Dtymk ENSMUST00000027503.14 deoxythymidylate kinase, transcript variant 1 (from RefSeq NM_001105667.1) ENSMUST00000027503.1 ENSMUST00000027503.10 ENSMUST00000027503.11 ENSMUST00000027503.12 ENSMUST00000027503.13 ENSMUST00000027503.2 ENSMUST00000027503.3 ENSMUST00000027503.4 ENSMUST00000027503.5 ENSMUST00000027503.6 ENSMUST00000027503.7 ENSMUST00000027503.8 ENSMUST00000027503.9 KTHY_MOUSE NM_001105667 P97930 Q8C2L0 Q8K2S2 Tmk uc007cek.1 uc007cek.2 uc007cek.3 Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+). Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517, ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Pyrimidine metabolism; dTTP biosynthesis. Homodimer. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=P97930-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P97930-2; Sequence=VSP_003029; Very low mRNA levels in the quiescent cells. As cells exit from G0 to G1 phase, the expression levels gradually increase. Belongs to the thymidylate kinase family. nucleotide binding nucleoside diphosphate kinase activity thymidylate kinase activity ATP binding nucleus cytoplasm mitochondrion mitochondrial intermembrane space mitochondrial matrix cytosol nucleoside diphosphate phosphorylation dUDP biosynthetic process dTDP biosynthetic process dTTP biosynthetic process uridylate kinase activity nucleotide biosynthetic process kinase activity phosphorylation transferase activity response to estrogen myoblast differentiation response to cadmium ion nucleoside monophosphate phosphorylation cellular response to growth factor stimulus uc007cek.1 uc007cek.2 uc007cek.3 
ENSMUST00000027505.13 Ing5 ENSMUST00000027505.13 inhibitor of growth family, member 5 (from RefSeq NM_025454.2) ENSMUST00000027505.1 ENSMUST00000027505.10 ENSMUST00000027505.11 ENSMUST00000027505.12 ENSMUST00000027505.2 ENSMUST00000027505.3 ENSMUST00000027505.4 ENSMUST00000027505.5 ENSMUST00000027505.6 ENSMUST00000027505.7 ENSMUST00000027505.8 ENSMUST00000027505.9 ING5_MOUSE NM_025454 Q3UL57 Q6P292 Q9CV64 Q9D8Y8 Q9D9V8 uc007cen.1 uc007cen.2 uc007cen.3 uc007cen.4 Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner. Component of the HBO1 complex composed of KAT7/HBO1, MEAF6, ING5, and one scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE scaffold (JADE1, JADE2 and JADE3) mediate acetylation of histone H4. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with H3K4me3 and to a lesser extent with H3K4me2. Interacts with EP300 and p53/TP53. Interacts with INCA1. Nucleus Chromosome Note=Localizes to transcription start sites. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D8Y8-1; Sequence=Displayed; Name=2; IsoId=Q9D8Y8-2; Sequence=VSP_012529; Name=3; IsoId=Q9D8Y8-3; Sequence=VSP_012530; The PHD-type zinc finger mediates the binding to H3K4me3. [Isoform 3]: May be due to a competing acceptor splice site. Belongs to the ING family. chromatin binding nucleus DNA replication chromatin organization protein acetylation negative regulation of cell proliferation histone acetylation methylated histone binding positive regulation of apoptotic process histone H3 acetylation positive regulation of transcription, DNA-templated negative regulation of growth metal ion binding MOZ/MORF histone acetyltransferase complex positive regulation of apoptotic signaling pathway uc007cen.1 uc007cen.2 uc007cen.3 uc007cen.4 
ENSMUST00000027507.9 Pdcd1 ENSMUST00000027507.9 programmed cell death 1 (from RefSeq NM_008798.3) ENSMUST00000027507.1 ENSMUST00000027507.2 ENSMUST00000027507.3 ENSMUST00000027507.4 ENSMUST00000027507.5 ENSMUST00000027507.6 ENSMUST00000027507.7 ENSMUST00000027507.8 NM_008798 Pdcd1 Q544F3 Q544F3_MOUSE uc007cev.1 uc007cev.2 membrane integral component of membrane negative regulation of immune response positive regulation of T cell apoptotic process uc007cev.1 uc007cev.2 
ENSMUST00000027512.13 Atg16l1 ENSMUST00000027512.13 autophagy related 16 like 1, transcript variant 2 (from RefSeq NM_029846.4) A16L1_MOUSE Apg16l Atg16l1 ENSMUST00000027512.1 ENSMUST00000027512.10 ENSMUST00000027512.11 ENSMUST00000027512.12 ENSMUST00000027512.2 ENSMUST00000027512.3 ENSMUST00000027512.4 ENSMUST00000027512.5 ENSMUST00000027512.6 ENSMUST00000027512.7 ENSMUST00000027512.8 ENSMUST00000027512.9 NM_029846 Q6KAT7 Q80U97 Q80U98 Q80U99 Q80Y53 Q8C0J2 Q9DB63 uc007bxl.1 uc007bxl.2 uc007bxl.3 uc007bxl.4 Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:12665549, PubMed:18849966, PubMed:19898471, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:33586810). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:33586810). During canonical autophagy, interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (By similarity). Thereby, controls the elongation of the nascent autophagosomal membrane (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (By similarity). Non- canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (PubMed:33586810). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (By similarity). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:19898471, PubMed:19966812, PubMed:24238340). Plays a role in regulating morphology and function of Paneth cell (By similarity). Homodimer (By similarity). Homooligomer (PubMed:12665549). Heterooligomer with ATG16L2 (PubMed:22082872). Interacts with WIPI1 (By similarity). Interacts with WIPI2 (PubMed:24954904). Interacts with RB1CC1; the interaction is required for ULK1 complex-dependent autophagy (PubMed:23392225, PubMed:23262492). Interacts with ATG5 (PubMed:12665549). Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Interacts with RAB33B (PubMed:18448665). Interacts (via WD repeats) with TMEM59; the interaction mediates unconventional autophagic activity of TMEM59 (By similarity). Interacts with TLR2 (By similarity). Interacts (via WD repeats) with MEFV (By similarity). Interacts (via N-terminal) with CLTC (By similarity). Interacts with NOD1 (PubMed:19898471). Interacts with NOD2 (PubMed:19898471, PubMed:19966812). Interacts with TUFM (By similarity). Interacts with TRIM16 (By similarity). Interacts (via WD repeats) with SPATA33 (PubMed:33087875). Interacts with Irgm1 (By similarity). Q8C0J2; Q99J83: Atg5; NbExp=4; IntAct=EBI-769195, EBI-2911848; Q8C0J2; P23242: Gja1; NbExp=2; IntAct=EBI-769195, EBI-298630; Q8C0J2; Q61025: Ift20; NbExp=2; IntAct=EBI-769195, EBI-16077253; Q8C0J2; Q9ESK9: Rb1cc1; NbExp=4; IntAct=EBI-769195, EBI-647302; Q8C0J2-2; Q8C0J2-2: Atg16l1; NbExp=2; IntAct=EBI-11580812, EBI-11580812; Q8C0J2-3; Q9ESK9: Rb1cc1; NbExp=3; IntAct=EBI-16029274, EBI-647302; Q8C0J2-3; Q9H1Y0: ATG5; Xeno; NbExp=2; IntAct=EBI-16029274, EBI-1047414; Q8C0J2-3; Q8TDY2: RB1CC1; Xeno; NbExp=6; IntAct=EBI-16029274, EBI-1047793; Cytoplasm Preautophagosomal structure membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Lysosome membrane ; Peripheral membrane protein Note=Recruited to omegasomes membranes by WIPI2 (PubMed:24954904). Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5 (PubMed:24954904). Localizes also to discrete punctae along the ciliary axoneme (PubMed:24954904). Upon activation of non-canonical autophagy, recruited to single- membrane endolysosomal compartments (By similarity). Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Apg16Lbeta ; IsoId=Q8C0J2-1; Sequence=Displayed; Name=2; Synonyms=Apg16Lalpha ; IsoId=Q8C0J2-2; Sequence=VSP_013391; Name=3; Synonyms=Apg16Lgamma ; IsoId=Q8C0J2-3; Sequence=VSP_013392; Name=4; IsoId=Q8C0J2-4; Sequence=VSP_013392, VSP_013394, VSP_013395; Name=5; IsoId=Q8C0J2-5; Sequence=VSP_013391, VSP_013393; Widely expressed (PubMed:12665549). Expressed in the testis and sperm midpiece (at protein level) (PubMed:33087875). [Isoform 1]: Expressed in liver. [Isoform 2]: Highly expressed in liver. [Isoform 3]: Expressed in brain. The WD repeats are required for non-canonical autophagy but not for canonical autophagy. Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli. Phosphorylation at Ser-139 promotes association with the ATG12- ATG5 conjugate to form the ATG12-ATG5-ATG16L1 complex. Belongs to the WD repeat ATG16 family. Sequence=BAD21370.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; autophagosome assembly autophagosome membrane protein binding cytoplasm autophagosome cytosol axoneme autophagy positive regulation of autophagy protein transport membrane pre-autophagosomal structure membrane protein localization to pre-autophagosomal structure negative stranded viral RNA replication identical protein binding GTPase binding protein lipidation involved in autophagosome assembly xenophagy uc007bxl.1 uc007bxl.2 uc007bxl.3 uc007bxl.4 
ENSMUST00000027517.14 Dgkd ENSMUST00000027517.14 diacylglycerol kinase, delta (from RefSeq NM_177646.3) DGKD_MOUSE Dgkd E9PUQ8 ENSMUST00000027517.1 ENSMUST00000027517.10 ENSMUST00000027517.11 ENSMUST00000027517.12 ENSMUST00000027517.13 ENSMUST00000027517.2 ENSMUST00000027517.3 ENSMUST00000027517.4 ENSMUST00000027517.5 ENSMUST00000027517.6 ENSMUST00000027517.7 ENSMUST00000027517.8 ENSMUST00000027517.9 NM_177646 uc011wos.1 uc011wos.2 uc011wos.3 Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:17021016). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:17021016). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (PubMed:17021016). May also regulate clathrin-dependent endocytosis (By similarity). Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10273; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40324; Evidence=; Lipid metabolism; glycerolipid metabolism. Homooligomer. Monomer. Interacts with AP2A2; regulates clathrin-dependent endocytosis. Cell membrane ; Peripheral membrane protein Membrane, clathrin-coated pit Cytoplasm Widely expressed. The SAM domain mediates homooligomerization. The PH domain mediates association with membranes. Homozygous knockout of dgkd is lethal (PubMed:17021016). Fetuses are smaller and newborn mice develop respiratory difficulty and die within 24 hours after birth (PubMed:17021016). They show an abnormal open-eyelids phenotype which is associated with significant reduction of the expression of the EGF receptor/EGFR in the basal layer of the epidermis (PubMed:17021016). Belongs to the eukaryotic diacylglycerol kinase family. nucleotide binding NAD+ kinase activity diacylglycerol kinase activity ATP binding cytoplasm cytosol plasma membrane signal transduction protein kinase C-activating G-protein coupled receptor signaling pathway response to organic substance kinase activity phosphorylation transferase activity cytoplasmic vesicle intracellular signal transduction identical protein binding protein homodimerization activity diacylglycerol metabolic process glycerolipid metabolic process lipid phosphorylation protein heterodimerization activity protein homooligomerization uc011wos.1 uc011wos.2 uc011wos.3 
ENSMUST00000027518.12 Spp2 ENSMUST00000027518.12 secreted phosphoprotein 2 (from RefSeq NM_029269.3) ENSMUST00000027518.1 ENSMUST00000027518.10 ENSMUST00000027518.11 ENSMUST00000027518.2 ENSMUST00000027518.3 ENSMUST00000027518.4 ENSMUST00000027518.5 ENSMUST00000027518.6 ENSMUST00000027518.7 ENSMUST00000027518.8 ENSMUST00000027518.9 NM_029269 Q8K1I3 Q9DCG1 SPP24_MOUSE Spp24 uc007byq.1 uc007byq.2 uc007byq.3 uc007byq.4 Could coordinate an aspect of bone turnover. Secreted. Phosphorylation sites are present in the extracellular medium. Belongs to the SPP2 family. molecular_function extracellular region macromolecular complex bone remodeling macromolecular complex assembly uc007byq.1 uc007byq.2 uc007byq.3 uc007byq.4 
ENSMUST00000027528.7 Mlph ENSMUST00000027528.7 melanophilin (from RefSeq NM_053015.3) A0A0R4J075 A0A0R4J075_MOUSE ENSMUST00000027528.1 ENSMUST00000027528.2 ENSMUST00000027528.3 ENSMUST00000027528.4 ENSMUST00000027528.5 ENSMUST00000027528.6 Mlph NM_053015 uc007bzm.1 uc007bzm.2 uc007bzm.3 uc007bzm.4 intracellular protein transport myosin binding Rab GTPase binding dendrite protein binding, bridging metal ion binding perinuclear region of cytoplasm uc007bzm.1 uc007bzm.2 uc007bzm.3 uc007bzm.4 
ENSMUST00000027529.12 Rab17 ENSMUST00000027529.12 RAB17, member RAS oncogene family, transcript variant 1 (from RefSeq NM_008998.4) ENSMUST00000027529.1 ENSMUST00000027529.10 ENSMUST00000027529.11 ENSMUST00000027529.2 ENSMUST00000027529.3 ENSMUST00000027529.4 ENSMUST00000027529.5 ENSMUST00000027529.6 ENSMUST00000027529.7 ENSMUST00000027529.8 ENSMUST00000027529.9 NM_008998 Q0PD39 Q0PD39_MOUSE Rab17 uc007bzo.1 uc007bzo.2 uc007bzo.3 uc007bzo.4 Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding GDP binding endocytic vesicle cilium assembly uc007bzo.1 uc007bzo.2 uc007bzo.3 uc007bzo.4 
ENSMUST00000027532.13 Scly ENSMUST00000027532.13 selenocysteine lyase (from RefSeq NM_016717.4) A0A0R4J069 A0A0R4J069_MOUSE ENSMUST00000027532.1 ENSMUST00000027532.10 ENSMUST00000027532.11 ENSMUST00000027532.12 ENSMUST00000027532.2 ENSMUST00000027532.3 ENSMUST00000027532.4 ENSMUST00000027532.5 ENSMUST00000027532.6 ENSMUST00000027532.7 ENSMUST00000027532.8 ENSMUST00000027532.9 NM_016717 Scly uc007caf.1 uc007caf.2 uc007caf.3 Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Homodimer. Cytoplasm, cytosol catalytic activity selenocysteine lyase activity selenocysteine catabolic process amino acid binding protein homodimerization activity vitamin B6 binding catalytic complex uc007caf.1 uc007caf.2 uc007caf.3 
ENSMUST00000027533.9 Klhl30 ENSMUST00000027533.9 kelch-like 30 (from RefSeq NM_027551.2) ENSMUST00000027533.1 ENSMUST00000027533.2 ENSMUST00000027533.3 ENSMUST00000027533.4 ENSMUST00000027533.5 ENSMUST00000027533.6 ENSMUST00000027533.7 ENSMUST00000027533.8 KLH30_MOUSE NM_027551 Q8C3F7 Q9D692 uc007cai.1 uc007cai.2 uc007cai.3 Sequence=BAB29415.1; Type=Frameshift; Evidence=; uc007cai.1 uc007cai.2 uc007cai.3 
ENSMUST00000027534.13 Ilkap ENSMUST00000027534.13 integrin-linked kinase-associated serine/threonine phosphatase 2C, transcript variant 1 (from RefSeq NM_023343.3) ENSMUST00000027534.1 ENSMUST00000027534.10 ENSMUST00000027534.11 ENSMUST00000027534.12 ENSMUST00000027534.2 ENSMUST00000027534.3 ENSMUST00000027534.4 ENSMUST00000027534.5 ENSMUST00000027534.6 ENSMUST00000027534.7 ENSMUST00000027534.8 ENSMUST00000027534.9 ILKAP_MOUSE NM_023343 Q05CC3 Q8R0F6 uc007cal.1 uc007cal.2 Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit. ; Interacts with ILK. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R0F6-1; Sequence=Displayed; Name=2; IsoId=Q8R0F6-2; Sequence=VSP_022384, VSP_022385; Belongs to the PP2C family. catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity nucleus nucleoplasm cytoplasm cytosol protein dephosphorylation hydrolase activity regulation of nuclear cell cycle DNA replication cation binding metal ion binding uc007cal.1 uc007cal.2 
ENSMUST00000027554.8 Cln8 ENSMUST00000027554.8 CLN8 transmembrane ER and ERGIC protein, transcript variant 1 (from RefSeq NM_012000.4) CLN8_MOUSE ENSMUST00000027554.1 ENSMUST00000027554.2 ENSMUST00000027554.3 ENSMUST00000027554.4 ENSMUST00000027554.5 ENSMUST00000027554.6 ENSMUST00000027554.7 NM_012000 Q9QUK3 uc009kze.1 uc009kze.2 uc009kze.3 uc009kze.4 Could play a role in cell proliferation during neuronal differentiation and in protection against cell death. Interacts with CLN5 (PubMed:19941651). Interacts with CLN3 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Endoplasmic reticulum Note=Defects in Cln8 are the cause of the phenotype motor neuron degeneration (mnd). Mnd is a naturally occurring mutant It is characterized by progressive motor system degeneration. It has intracellular autofluorescent inclusions similar to those seen in human Cln8. age-dependent response to oxidative stress protein binding mitochondrion endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment phospholipid metabolic process ceramide metabolic process mitochondrial membrane organization lysosome organization nervous system development visual perception adult walking behavior cholesterol metabolic process associative learning adult locomotory behavior regulation of cell size membrane integral component of membrane spinal cord motor neuron differentiation somatic motor neuron differentiation endoplasmic reticulum-Golgi intermediate compartment membrane social behavior negative regulation of apoptotic process cellular protein catabolic process cellular macromolecule catabolic process cellular protein metabolic process photoreceptor cell maintenance musculoskeletal movement neuromuscular process controlling posture neuromuscular process controlling balance glutamate reuptake retina development in camera-type eye neurofilament cytoskeleton organization presynapse uc009kze.1 uc009kze.2 uc009kze.3 uc009kze.4 
ENSMUST00000027559.9 Tnfrsf11a ENSMUST00000027559.9 tumor necrosis factor receptor superfamily, member 11a, NFKB activator (from RefSeq NM_009399.5) ENSMUST00000027559.1 ENSMUST00000027559.2 ENSMUST00000027559.3 ENSMUST00000027559.4 ENSMUST00000027559.5 ENSMUST00000027559.6 ENSMUST00000027559.7 ENSMUST00000027559.8 NM_009399 O35305 Q8VCT7 Rank TNR11_MOUSE uc007cgp.1 uc007cgp.2 uc007cgp.3 Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL- mediated osteoclastogenesis (PubMed:9878548, PubMed:23478294, PubMed:20483727). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (PubMed:23478294). Involved in the regulation of interactions between T-cells and dendritic cells (PubMed:9367155). Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer (PubMed:20483727, PubMed:23039992). Part of a complex composed of EEIG1, TNFRSF11A/RANK, PLCG2, GAB2, TEC and BTK; complex formation increases in the presence of TNFSF11/RANKL (PubMed:23478294). Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 (By similarity). Interacts (via cytoplasmic domain) with GAB2 (By similarity). Interacts (via cytoplasmic domain); with EEIG1 (via N- terminus); when in the presence of TNFSF11/RANKL (PubMed:23478294). O35305; Q9Z1R2: Bag6; NbExp=4; IntAct=EBI-647362, EBI-644645; O35305; O35235-1: Tnfsf11; NbExp=6; IntAct=EBI-647362, EBI-15890886; O35305; P39429: Traf2; NbExp=2; IntAct=EBI-647362, EBI-520016; O35305; Q60803: Traf3; NbExp=3; IntAct=EBI-647362, EBI-520135; O35305; P70196: Traf6; NbExp=2; IntAct=EBI-647362, EBI-448028; Cell membrane ; Single-pass type I membrane protein Membrane raft Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow. ossification adaptive immune response transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity protein binding cytosol plasma membrane multicellular organism development response to radiation external side of plasma membrane cell surface membrane integral component of membrane cytokine binding osteoclast differentiation response to lipopolysaccharide tumor necrosis factor-mediated signaling pathway response to cytokine response to tumor necrosis factor positive regulation of JUN kinase activity positive regulation of bone resorption metal ion binding lymph node development positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity circadian temperature homeostasis mammary gland alveolus development response to interleukin-1 positive regulation of fever generation by positive regulation of prostaglandin secretion TNFSF11-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling multinuclear osteoclast differentiation uc007cgp.1 uc007cgp.2 uc007cgp.3 
ENSMUST00000027564.8 Serpinb13 ENSMUST00000027564.8 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13 (from RefSeq NM_172852.3) ENSMUST00000027564.1 ENSMUST00000027564.2 ENSMUST00000027564.3 ENSMUST00000027564.4 ENSMUST00000027564.5 ENSMUST00000027564.6 ENSMUST00000027564.7 NM_172852 Q148S5 Q148S6 Q8CDC0 SPB13_MOUSE uc007chf.1 uc007chf.2 May play a role in the proliferation or differentiation of keratinocytes. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CDC0-1; Sequence=Displayed; Name=2; IsoId=Q8CDC0-2; Sequence=VSP_039855; Belongs to the serpin family. Ov-serpin subfamily. protease binding serine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular space nucleoplasm cytoplasm cytosol negative regulation of peptidase activity negative regulation of endopeptidase activity nuclear speck peptidase inhibitor activity negative regulation of keratinocyte apoptotic process uc007chf.1 uc007chf.2 
ENSMUST00000027565.5 Serpinb3c ENSMUST00000027565.5 serine (or cysteine) peptidase inhibitor, clade B, member 3C (from RefSeq NM_201363.2) A2RSF9 A2RSF9_MOUSE ENSMUST00000027565.1 ENSMUST00000027565.2 ENSMUST00000027565.3 ENSMUST00000027565.4 NM_201363 Serpinb3c uc007chk.1 uc007chk.2 uc007chk.3 Belongs to the serpin family. Ov-serpin subfamily. serine-type endopeptidase inhibitor activity protein binding extracellular space negative regulation of endopeptidase activity uc007chk.1 uc007chk.2 uc007chk.3 
ENSMUST00000027566.3 Serpinb11 ENSMUST00000027566.3 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11 (from RefSeq NM_025867.2) ENSMUST00000027566.1 ENSMUST00000027566.2 NM_025867 Q91Z12 Q9CQV3 SPB11_MOUSE uc007chl.1 uc007chl.2 uc007chl.3 Inhibitor of serine proteases. Has moderate inhibitory activity for trypsin-like peptidases, but also some activity with cysteine peptidases, cathepsin L, K, and V, and the serine peptidase, tryptase gamma. Cytoplasm Expressed in eye, lung, lymphocytes, thymus, stomach, uterus, heart, brain, liver, skeletal muscle, and in day 7, 15, and 17 embryos. Belongs to the serpin family. Ov-serpin subfamily. serine-type endopeptidase inhibitor activity extracellular space cytoplasm negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc007chl.1 uc007chl.2 uc007chl.3 
ENSMUST00000027569.14 Slco6c1 ENSMUST00000027569.14 solute carrier organic anion transporter family, member 6c1 (from RefSeq NM_028942.4) ENSMUST00000027569.1 ENSMUST00000027569.10 ENSMUST00000027569.11 ENSMUST00000027569.12 ENSMUST00000027569.13 ENSMUST00000027569.2 ENSMUST00000027569.3 ENSMUST00000027569.4 ENSMUST00000027569.5 ENSMUST00000027569.6 ENSMUST00000027569.7 ENSMUST00000027569.8 ENSMUST00000027569.9 NM_028942 Q3V161 Q8C0X7 Q9D4B7 SO6C1_MOUSE Slco6c1 uc007cff.1 uc007cff.2 uc007cff.3 Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG2, CATSPERD, CATSPERE, CATSPERZ, C2CD6/CATSPERT, SLCO6C1, TMEM249, TMEM262 and EFCAB9 (PubMed:34225353). HSPA1 may be an additional auxiliary complex member (By similarity). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (PubMed:34225353). The auxiliary CATSPERB, CATSPERG2, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively (PubMed:34225353). SLCO6C1 interacts with CATSPERE and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex (PubMed:34225353) (By similarity). C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane (Probable). Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C0X7-1; Sequence=Displayed; Name=2; IsoId=Q8C0X7-2; Sequence=VSP_061423; Belongs to the organo anion transporter (TC 2.A.60) family. integral component of plasma membrane organic anion transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity organic anion transport membrane integral component of membrane sodium-independent organic anion transport transmembrane transport uc007cff.1 uc007cff.2 uc007cff.3 
ENSMUST00000027575.13 Slco6d1 ENSMUST00000027575.13 solute carrier organic anion transporter family, member 6d1, transcript variant 1 (from RefSeq NM_027584.1) ENSMUST00000027575.1 ENSMUST00000027575.10 ENSMUST00000027575.11 ENSMUST00000027575.12 ENSMUST00000027575.2 ENSMUST00000027575.3 ENSMUST00000027575.4 ENSMUST00000027575.5 ENSMUST00000027575.6 ENSMUST00000027575.7 ENSMUST00000027575.8 ENSMUST00000027575.9 NM_027584 Q9D5W6 Q9D5W6_MOUSE Slco6d1 uc007cfu.1 uc007cfu.2 uc007cfu.3 Membrane ; Multi- pass membrane protein Belongs to the organo anion transporter (TC 2.A.60) family. integral component of plasma membrane sodium-independent organic anion transmembrane transporter activity membrane integral component of membrane sodium-independent organic anion transport transmembrane transport uc007cfu.1 uc007cfu.2 uc007cfu.3 
ENSMUST00000027579.17 Actr3 ENSMUST00000027579.17 ARP3 actin-related protein 3, transcript variant 3 (from RefSeq NM_001205386.1) ARP3_MOUSE Arp3 ENSMUST00000027579.1 ENSMUST00000027579.10 ENSMUST00000027579.11 ENSMUST00000027579.12 ENSMUST00000027579.13 ENSMUST00000027579.14 ENSMUST00000027579.15 ENSMUST00000027579.16 ENSMUST00000027579.2 ENSMUST00000027579.3 ENSMUST00000027579.4 ENSMUST00000027579.5 ENSMUST00000027579.6 ENSMUST00000027579.7 ENSMUST00000027579.8 ENSMUST00000027579.9 NM_001205386 Q99JY9 Q9DC56 uc029qta.1 uc029qta.2 ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis. Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Interacts weakly with MEFV. Interacts with AVIL. (Microbial infection) Interacts with bacterium B.thailandensis BimA. Q99JY9; Q60598: Cttn; NbExp=5; IntAct=EBI-773994, EBI-397955; Cytoplasm, cytoskeleton Cell projection Nucleus Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes). Belongs to the actin family. ARP3 subfamily. Golgi membrane nucleotide binding ruffle podosome actin binding structural constituent of cytoskeleton protein binding ATP binding nucleus cytoplasm cytoskeleton Arp2/3 protein complex brush border cell-cell junction actin filament organization establishment or maintenance of cell polarity asymmetric cell division positive regulation of lamellipodium assembly positive regulation of fibroblast migration meiotic chromosome movement towards spindle pole lamellipodium cell projection organization hemidesmosome actin cortical patch negative regulation of axon extension positive regulation of actin filament polymerization cell leading edge positive regulation of protein binding meiotic cytokinesis Arp2/3 complex-mediated actin nucleation site of double-strand break cell projection regulation of myosin II filament organization positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm astrocyte differentiation positive regulation of astrocyte differentiation positive regulation of dendrite morphogenesis actin filament binding ATPase binding meiotic cell cycle positive regulation of filopodium assembly spindle localization positive regulation of synapse assembly excitatory synapse cilium assembly positive regulation of dendritic spine morphogenesis cellular response to interferon-gamma cellular response to tumor necrosis factor cellular response to transforming growth factor beta stimulus positive regulation of protein targeting to membrane postsynapse postsynaptic actin cytoskeleton organization glutamatergic synapse positive regulation of protein localization to plasma membrane negative regulation of bleb assembly positive regulation of actin cytoskeleton reorganization actin filament uc029qta.1 uc029qta.2 
ENSMUST00000027580.11 Slc35f5 ENSMUST00000027580.11 solute carrier family 35, member F5, transcript variant 1 (from RefSeq NM_028787.5) ENSMUST00000027580.1 ENSMUST00000027580.10 ENSMUST00000027580.2 ENSMUST00000027580.3 ENSMUST00000027580.4 ENSMUST00000027580.5 ENSMUST00000027580.6 ENSMUST00000027580.7 ENSMUST00000027580.8 ENSMUST00000027580.9 NM_028787 Q8R314 Q9DBK9 S35F5_MOUSE uc007ckg.1 uc007ckg.2 uc007ckg.3 Putative solute transporter. Membrane ; Multi-pass membrane protein Belongs to the SLC35F solute transporter family. molecular_function cellular_component membrane integral component of membrane uc007ckg.1 uc007ckg.2 uc007ckg.3 
ENSMUST00000027581.7 Gpr39 ENSMUST00000027581.7 G protein-coupled receptor 39 (from RefSeq NM_027677.3) A0A0B4J1E4 A0A0B4J1E4_MOUSE ENSMUST00000027581.1 ENSMUST00000027581.2 ENSMUST00000027581.3 ENSMUST00000027581.4 ENSMUST00000027581.5 ENSMUST00000027581.6 Gpr39 NM_027677 uc007ckh.1 uc007ckh.2 uc007ckh.3 uc007ckh.4 uc007ckh.5 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc007ckh.1 uc007ckh.2 uc007ckh.3 uc007ckh.4 uc007ckh.5 
ENSMUST00000027592.6 Ubxn4 ENSMUST00000027592.6 UBX domain protein 4, transcript variant 1 (from RefSeq NM_026390.3) A0A0R4J078 A0A0R4J078_MOUSE ENSMUST00000027592.1 ENSMUST00000027592.2 ENSMUST00000027592.3 ENSMUST00000027592.4 ENSMUST00000027592.5 NM_026390 Ubxn4 uc007cll.1 uc007cll.2 uc007cll.3 Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1. Endoplasmic reticulum membrane ; Peripheral membrane protein Membrane ; Peripheral membrane protein Nucleus envelope endoplasmic reticulum cytosol ER-associated ubiquitin-dependent protein catabolic process uc007cll.1 uc007cll.2 uc007cll.3 
ENSMUST00000027601.11 Mcm6 ENSMUST00000027601.11 minichromosome maintenance complex component 6, transcript variant 1 (from RefSeq NM_008567.2) ENSMUST00000027601.1 ENSMUST00000027601.10 ENSMUST00000027601.2 ENSMUST00000027601.3 ENSMUST00000027601.4 ENSMUST00000027601.5 ENSMUST00000027601.6 ENSMUST00000027601.7 ENSMUST00000027601.8 ENSMUST00000027601.9 Mcm6 NM_008567 Q542I2 Q542I2_MOUSE uc007cln.1 uc007cln.2 uc007cln.3 uc007cln.4 Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Component of the MCM2-7 complex. Chromosome Nucleus Belongs to the MCM family. nucleotide binding DNA binding DNA helicase activity helicase activity ATP binding nucleus nucleoplasm DNA replication DNA replication initiation hydrolase activity DNA duplex unwinding MCM complex identical protein binding uc007cln.1 uc007cln.2 uc007cln.3 uc007cln.4 
ENSMUST00000027602.15 Dars1 ENSMUST00000027602.15 aspartyl-tRNA synthetase 1, transcript variant 1 (from RefSeq NM_177445.5) Dars ENSMUST00000027602.1 ENSMUST00000027602.10 ENSMUST00000027602.11 ENSMUST00000027602.12 ENSMUST00000027602.13 ENSMUST00000027602.14 ENSMUST00000027602.2 ENSMUST00000027602.3 ENSMUST00000027602.4 ENSMUST00000027602.5 ENSMUST00000027602.6 ENSMUST00000027602.7 ENSMUST00000027602.8 ENSMUST00000027602.9 NM_177445 Q3U987 Q922B2 SYDC_MOUSE uc007clp.1 uc007clp.2 uc007clp.3 uc007clp.4 Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Reaction=ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L- aspartyl-tRNA(Asp); Xref=Rhea:RHEA:19649, Rhea:RHEA-COMP:9660, Rhea:RHEA-COMP:9678, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78516, ChEBI:CHEBI:456215; EC=6.1.1.12; Evidence=; Homodimer (By similarity). Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:12060739). Cytoplasm. Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. nucleotide binding nucleic acid binding RNA binding aminoacyl-tRNA ligase activity aspartate-tRNA ligase activity ATP binding cytoplasm cytosol translation tRNA aminoacylation for protein translation aspartyl-tRNA aminoacylation ligase activity aminoacyl-tRNA synthetase multienzyme complex synapse uc007clp.1 uc007clp.2 uc007clp.3 uc007clp.4 
ENSMUST00000027603.4 Rgs18 ENSMUST00000027603.4 regulator of G-protein signaling 18, transcript variant 1 (from RefSeq NM_022881.6) ENSMUST00000027603.1 ENSMUST00000027603.2 ENSMUST00000027603.3 NM_022881 Q99PG4 RGS18_MOUSE uc007cxl.1 uc007cxl.2 uc007cxl.3 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha. Cytoplasm. Expressed in bone marrow, spleen, fetal liver and lung. At very low levels expressed in heart. GTPase activator activity cytoplasm G-protein coupled receptor signaling pathway regulation of G-protein coupled receptor protein signaling pathway negative regulation of signal transduction positive regulation of GTPase activity uc007cxl.1 uc007cxl.2 uc007cxl.3 
ENSMUST00000027615.7 F13b ENSMUST00000027615.7 coagulation factor XIII, beta subunit (from RefSeq NM_031164.2) B1AY02 Cf13b ENSMUST00000027615.1 ENSMUST00000027615.2 ENSMUST00000027615.3 ENSMUST00000027615.4 ENSMUST00000027615.5 ENSMUST00000027615.6 F13B_MOUSE NM_031164 Q07968 uc007cwk.1 uc007cwk.2 uc007cwk.3 uc007cwk.4 This gene encodes subunit B of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit A to form a heterotetrameric protein that circulates in the plasma. During the blood coagulation process, thrombin-mediated proteolytic cleavage of the subunit A results in the dissociation of the encoded protein from the heterotetramer. Male mice lacking the encoded protein exhibit mild fibrosis together with hemosiderin deposits in the heart. [provided by RefSeq, Sep 2015]. ##Evidence-Data-START## Transcript exon combination :: D10071.1, AK149397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Tetramer of two A chains (F13A1) and two B (F13B) chains. Secreted Predominantly expressed in liver and kidney. Sequence=BAA00963.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; enzyme inhibitor activity protein binding cellular_component extracellular region blood coagulation hemostasis negative regulation of catalytic activity negative regulation of cellular protein catabolic process uc007cwk.1 uc007cwk.2 uc007cwk.3 uc007cwk.4 
ENSMUST00000027623.9 Tsn ENSMUST00000027623.9 translin, transcript variant 1 (from RefSeq NM_011650.4) ENSMUST00000027623.1 ENSMUST00000027623.2 ENSMUST00000027623.3 ENSMUST00000027623.4 ENSMUST00000027623.5 ENSMUST00000027623.6 ENSMUST00000027623.7 ENSMUST00000027623.8 NM_011650 Q62348 TSN_MOUSE uc007cib.1 uc007cib.2 uc007cib.3 uc007cib.4 DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand. Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. Cytoplasm Nucleus. Belongs to the translin family. DNA binding single-stranded DNA binding RNA binding mRNA binding nuclease activity endonuclease activity endoribonuclease activity protein binding nucleus cytoplasm RNA metabolic process hydrolase activity identical protein binding sequence-specific DNA binding macromolecular complex binding nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc007cib.1 uc007cib.2 uc007cib.3 uc007cib.4 
ENSMUST00000027626.13 Nifk ENSMUST00000027626.13 nucleolar protein interacting with the FHA domain of MKI67 (from RefSeq NM_026472.4) ENSMUST00000027626.1 ENSMUST00000027626.10 ENSMUST00000027626.11 ENSMUST00000027626.12 ENSMUST00000027626.2 ENSMUST00000027626.3 ENSMUST00000027626.4 ENSMUST00000027626.5 ENSMUST00000027626.6 ENSMUST00000027626.7 ENSMUST00000027626.8 ENSMUST00000027626.9 MK67I_MOUSE Mki67ip NM_026472 Q8BMV9 Q8BVL4 Q91VE6 uc007cic.1 uc007cic.2 uc007cic.3 uc007cic.4 Binds to the FHA domain of MKI67; this interaction is enhanced in mitosis. Nucleus, nucleolus. Chromosome Note=Localizes to mitotic chromosomes in conjunction with MKI67. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VE6-1; Sequence=Displayed; Name=2; IsoId=Q91VE6-2; Sequence=VSP_014634; Expressed in brain, heart, hind limb muscles, intestine, liver, skin and spleen. Phosphorylated. Citrullinated by PADI4. condensed nuclear chromosome nucleic acid binding RNA binding nucleus nucleoplasm chromosome nucleolus cytoplasm uc007cic.1 uc007cic.2 uc007cic.3 uc007cic.4 
ENSMUST00000027629.10 Tfcp2l1 ENSMUST00000027629.10 transcription factor CP2-like 1 (from RefSeq NM_023755.2) Crtr1 ENSMUST00000027629.1 ENSMUST00000027629.2 ENSMUST00000027629.3 ENSMUST00000027629.4 ENSMUST00000027629.5 ENSMUST00000027629.6 ENSMUST00000027629.7 ENSMUST00000027629.8 ENSMUST00000027629.9 NM_023755 Q14AW3 Q3UNW5 Q99PF2 TF2L1_MOUSE Tcfcp2l1 uc007cil.1 uc007cil.2 uc007cil.3 Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:23942233, PubMed:26321140). With Klf2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/Stat3 and Wnt/beta-catenin signaling (PubMed:23942238, PubMed:23942233, PubMed:26321140). Required for normal duct development in the salivary gland and kidney (PubMed:17079272). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid- base and salt-water homeostasis, respectively (PubMed:28577314). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, Oxgr1, Ca12, Slc4a1, Aqp6 and IC-specific transcription factor Foxi1 (PubMed:28577314). Regulates also the expression of Jag1 and subsequent notch signaling in the collecting duct (PubMed:28577314). Jag1 initiates notch signaling in PCs but inhibits notch signaling in ICs (PubMed:28577314). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (PubMed:11073954). Modulates the placental expression of CYP11A1 (By similarity). Forms homohexamers via its SAM-like domain (By similarity). Interacts with Mta1; which is indispensable for Tfcp2l1-mediated self- renewal-promoting effect and endoderm-inhibiting action (PubMed:28982712). Q3UNW5; Q61539: Esrrb; NbExp=4; IntAct=EBI-5691372, EBI-2312731; Nucleus Highly expressed in placenta, testis, small intestine, kidney and stomach (PubMed:11073954, PubMed:17079272). Low levels of expression in lung, mesenteric lymph nodes, muscle, ovary, and thymus (PubMed:11073954). No expression was detected in brain, heart, liver, and spleen (PubMed:11073954). Expressed in eccrine glands in the palm (PubMed:11073954). Expression is prominent in both kidney collecting ducts intercalated (IC) and principal (PC) cells (PubMed:28577314). Also expressed in the thick limb of Henle and connecting segments of the nephron (PubMed:28577314). Expressed at low levels in 10.5- and 11.5-dpc embryos. Expression was not detected at 12.5- and 13.5-dpc. Highly expressed in the epithelial monolayer lining in a subset of tubules of embryonic kidney cortex. Low levels of expression were detected in 16.5-dpc embryonic intestine, limb, lung, and skin. No expression was detected in the brain. Expression is regulated in at least two distinct sites, the pluripotent cells of the developing embryo and the epithelial cells lining the embryonic kidney distal convoluted tubules. Expressed in the ducts of submandibular and sublingual glands, isolated submandibular gland, parotid and lachrymal glands and nasal gland in 16 dpc embryos. At birth, the expression is detected in minor nasal glands in the olfactory epithelium, ducts of the mammary gland, male reproductive system, endolymphatic sac and lung. Expressed during renal development; first detected in the ureteric epithelium, at the distal end of the S-shaped body in nephron and subsequently in all nephric tubule, with expression localizing to more distal regions in the nephron during the maturation of the kidney. The Grh/CP2 DB domain is required for direct DNA-binding (By similarity). The Grh/CP2 DB domain is essential to maintain the undifferentiated state of embryonic stem cells (PubMed:28982712). The SAM-like domain is required for homohexamerization (By similarity). Approximately half of the mutant mice die before weaning and show growth retardation during early postnatal stages. Mice display defects in the morphology of the submandibular ducts, abnormalities in the maturation of renal tubules and abnormal composition of saliva and urine (PubMed:17079272). Leads to a decrease in the expression of pluripotency genes (Nanog, Oct4, Sox2 and Esrrb), while resulted in up-regulation of some endoderm (Sox17, Gata4 and Gata6), mesoderm (T and Mixl1) and trophectoderm (Cdx2, Eomes, and Elf5) markers (PubMed:28982712). Belongs to the grh/CP2 family. CP2 subfamily. negative regulation of transcription from RNA polymerase II promoter cell morphogenesis RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding fibrillar center epithelial cell maturation DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm mitochondrion regulation of transcription from RNA polymerase II promoter cytoplasm organization salivary gland development determination of adult lifespan membrane sequence-specific DNA binding positive regulation of growth uc007cil.1 uc007cil.2 uc007cil.3 
ENSMUST00000027634.13 Dbi ENSMUST00000027634.13 diazepam binding inhibitor, transcript variant 2 (from RefSeq NM_007830.4) Dbi ENSMUST00000027634.1 ENSMUST00000027634.10 ENSMUST00000027634.11 ENSMUST00000027634.12 ENSMUST00000027634.2 ENSMUST00000027634.3 ENSMUST00000027634.4 ENSMUST00000027634.5 ENSMUST00000027634.6 ENSMUST00000027634.7 ENSMUST00000027634.8 ENSMUST00000027634.9 NM_007830 Q548W7 Q548W7_MOUSE uc007cjf.1 uc007cjf.2 uc007cjf.3 uc007cjf.4 Endoplasmic reticulum Golgi apparatus fatty-acyl-CoA binding uc007cjf.1 uc007cjf.2 uc007cjf.3 uc007cjf.4 
ENSMUST00000027639.8 Marco ENSMUST00000027639.8 macrophage receptor with collagenous structure (from RefSeq NM_010766.3) ENSMUST00000027639.1 ENSMUST00000027639.2 ENSMUST00000027639.3 ENSMUST00000027639.4 ENSMUST00000027639.5 ENSMUST00000027639.6 ENSMUST00000027639.7 MARCO_MOUSE NM_010766 Q60754 uc007cjl.1 uc007cjl.2 uc007cjl.3 Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:7867067). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (By similarity). Homotrimer; disulfide-linked (PubMed:7867067). Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands (PubMed:17405873). Cell membrane ; Single-pass type II membrane protein Expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes (at protein level). N-glycosylated. beta-amyloid binding G-protein coupled receptor binding positive regulation of protein phosphorylation immune system process scavenger receptor activity collagen trimer collagen type XI trimer cytoplasm plasma membrane endocytosis receptor-mediated endocytosis phagocytosis, engulfment adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway membrane integral component of membrane cargo receptor activity apoptotic cell clearance innate immune response positive regulation of ERK1 and ERK2 cascade beta-amyloid clearance uc007cjl.1 uc007cjl.2 uc007cjl.3 
ENSMUST00000027643.6 Atp6v1g3 ENSMUST00000027643.6 ATPase, H+ transporting, lysosomal V1 subunit G3 (from RefSeq NM_177397.3) Atp6g3 ENSMUST00000027643.1 ENSMUST00000027643.2 ENSMUST00000027643.3 ENSMUST00000027643.4 ENSMUST00000027643.5 NM_177397 Q8BMC1 VATG3_MOUSE uc007cvm.1 uc007cvm.2 Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Kidney. Belongs to the V-ATPase G subunit family. cytosol plasma membrane ion transport hydrogen-exporting ATPase activity, phosphorylative mechanism membrane vacuolar proton-transporting V-type ATPase complex ATPase activity, coupled to transmembrane movement of substances ATPase binding hydrogen ion transmembrane transport uc007cvm.1 uc007cvm.2 
ENSMUST00000027650.13 Cd55 ENSMUST00000027650.13 CD55 molecule, decay accelerating factor for complement, transcript variant 4 (from RefSeq NR_175895.1) Cd55a DAF1_MOUSE Daf Daf1 ENSMUST00000027650.1 ENSMUST00000027650.10 ENSMUST00000027650.11 ENSMUST00000027650.12 ENSMUST00000027650.2 ENSMUST00000027650.3 ENSMUST00000027650.4 ENSMUST00000027650.5 ENSMUST00000027650.6 ENSMUST00000027650.7 ENSMUST00000027650.8 ENSMUST00000027650.9 NR_175895 P97732 Q3TU32 Q4FJS4 Q61397 Q61475 Q76N72 Q921P0 Q9R1C1 uc007cly.1 uc007cly.2 uc007cly.3 uc007cly.4 This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage. Cell membrane ; Lipid-anchor, GPI- anchor Brain, secretory epithelia, skeletal muscle, liver, testes, thymus, spleen and lymph node. The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity). Belongs to the receptors of complement activation (RCA) family. virus receptor activity immune system process enzyme inhibitor activity plasma membrane complement activation, classical pathway lipid binding external side of plasma membrane cell surface membrane apical plasma membrane regulation of complement activation regulation of complement activation, classical pathway anchored component of membrane negative regulation of catalytic activity innate immune response membrane raft negative regulation of complement activation viral entry into host cell regulation of complement-dependent cytotoxicity uc007cly.1 uc007cly.2 uc007cly.3 uc007cly.4 
ENSMUST00000027655.8 Ddx59 ENSMUST00000027655.8 DEAD box helicase 59 (from RefSeq NM_026500.3) DDX59_MOUSE ENSMUST00000027655.1 ENSMUST00000027655.2 ENSMUST00000027655.3 ENSMUST00000027655.4 ENSMUST00000027655.5 ENSMUST00000027655.6 ENSMUST00000027655.7 NM_026500 Q8C667 Q9CSD1 Q9DBN9 Znhit5 uc007cuu.1 uc007cuu.2 uc007cuu.3 uc007cuu.4 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP. Cytoplasm Nucleus Note=Exhibits granular localization in the nucleus, as well as in the cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DBN9-1; Sequence=Displayed; Name=2; IsoId=Q9DBN9-2; Sequence=VSP_026429, VSP_026430; AT 11.5 dpc, expressed in the developing snout region, eye and limb buds. At 13.5 dpc, highly enriched in the lips, palatal shelves (secondary palate), and developing limb buds. The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. Belongs to the DEAD box helicase family. DDX59 subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus cytoplasm hydrolase activity metal ion binding uc007cuu.1 uc007cuu.2 uc007cuu.3 uc007cuu.4 
ENSMUST00000027657.14 C4bp ENSMUST00000027657.14 complement component 4 binding protein, transcript variant 1 (from RefSeq NM_007576.4) C4BPA_MOUSE C4bpa ENSMUST00000027657.1 ENSMUST00000027657.10 ENSMUST00000027657.11 ENSMUST00000027657.12 ENSMUST00000027657.13 ENSMUST00000027657.2 ENSMUST00000027657.3 ENSMUST00000027657.4 ENSMUST00000027657.5 ENSMUST00000027657.6 ENSMUST00000027657.7 ENSMUST00000027657.8 ENSMUST00000027657.9 NM_007576 P08607 Q91X48 uc007cmc.1 uc007cmc.2 uc007cmc.3 Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. Homoheptamer; not covalently linked. Mouse lacks the beta chain of C4BP. P08607; Q13873: BMPR2; Xeno; NbExp=3; IntAct=EBI-527325, EBI-527196; Secreted. It is uncertain whether Met-1 or Met-44 is the initiator. Sequence=AAA37312.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; immune system process protein binding extracellular region complement activation, classical pathway innate immune response uc007cmc.1 uc007cmc.2 uc007cmc.3 
ENSMUST00000027667.13 Pkp1 ENSMUST00000027667.13 plakophilin 1, transcript variant 1 (from RefSeq NM_019645.3) B2RSX3 ENSMUST00000027667.1 ENSMUST00000027667.10 ENSMUST00000027667.11 ENSMUST00000027667.12 ENSMUST00000027667.2 ENSMUST00000027667.3 ENSMUST00000027667.4 ENSMUST00000027667.5 ENSMUST00000027667.6 ENSMUST00000027667.7 ENSMUST00000027667.8 ENSMUST00000027667.9 NM_019645 P97350 PKP1_MOUSE uc007cub.1 uc007cub.2 uc007cub.3 uc007cub.4 Seems to play a role in junctional plaques (By similarity). May facilitate the formation of intermediate filaments (By similarity). Interacts (via N-terminus) with KRT5/CK5, KRT8/CK8 (via rod domain), KRT15/CK15 and KRT18/CK18 (via rod domain) as part of intermediate filaments (By similarity). Interacts with VIM (via rod domain) (By similarity). Interacts with DSP (By similarity). Interacts with DES (PubMed:10852826). Nucleus Belongs to the beta-catenin family. protein binding lamin binding nucleus nucleoplasm cytoplasm plasma membrane cell-cell junction cell-cell adherens junction cell-cell junction assembly cell adhesion positive regulation of gene expression cell junction desmosome intracellular membrane-bounded organelle intermediate filament bundle assembly cadherin binding cell-cell adhesion negative regulation of mRNA catabolic process messenger ribonucleoprotein complex uc007cub.1 uc007cub.2 uc007cub.3 uc007cub.4 
ENSMUST00000027670.4 Fcamr ENSMUST00000027670.4 Fc receptor, IgA, IgM, high affinity, transcript variant 2 (from RefSeq NM_144960.2) ENSMUST00000027670.1 ENSMUST00000027670.2 ENSMUST00000027670.3 FCAMR_MOUSE NM_144960 Q2TB54 Q2TB55 Q920L8 Q9EQT7 uc007cmk.1 uc007cmk.2 Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM. Interacts with IGHM; this interaction facilitates the endocytosis of IgM-coated microbes and IgM-antigen immune complexes. Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2TB54-1; Sequence=Displayed; Name=2; IsoId=Q2TB54-2; Sequence=VSP_033233; Expressed in several tissues including thymus, spleen, liver, kidney, small and large intestine, testis and placenta. Expressed by oligodendrocytes, B-cells and macrophages but not granulocytes, T-cells or NK cells (at protein level). N-glycosylated. IgM binding adaptive immune response immune system process transmembrane signaling receptor activity plasma membrane immune response membrane integral component of membrane IgA binding uc007cmk.1 uc007cmk.2 
ENSMUST00000027673.11 Il20 ENSMUST00000027673.11 interleukin 20, transcript variant 1 (from RefSeq NM_021380.2) ENSMUST00000027673.1 ENSMUST00000027673.10 ENSMUST00000027673.2 ENSMUST00000027673.3 ENSMUST00000027673.4 ENSMUST00000027673.5 ENSMUST00000027673.6 ENSMUST00000027673.7 ENSMUST00000027673.8 ENSMUST00000027673.9 IL20_MOUSE NM_021380 Q9JKV9 Zcyto10 uc007cmr.1 uc007cmr.2 uc007cmr.3 uc007cmr.4 Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation (PubMed:23793061). Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity. Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration. Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB. Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB (By similarity). Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2 (PubMed:17878297). Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes (By similarity). Forms a 1:1:1 heterotrimeric complex with its primary high- affinity heterodimeric receptor IL20RA/IL20RB. Secreted. Belongs to the IL-10 family. receptor binding cytokine activity extracellular region extracellular space signal transduction hemopoiesis interleukin-20 receptor binding interleukin-22 receptor binding positive regulation of osteoclast differentiation uc007cmr.1 uc007cmr.2 uc007cmr.3 uc007cmr.4 
ENSMUST00000027675.14 Pigr ENSMUST00000027675.14 polymeric immunoglobulin receptor (from RefSeq NM_011082.3) ENSMUST00000027675.1 ENSMUST00000027675.10 ENSMUST00000027675.11 ENSMUST00000027675.12 ENSMUST00000027675.13 ENSMUST00000027675.2 ENSMUST00000027675.3 ENSMUST00000027675.4 ENSMUST00000027675.5 ENSMUST00000027675.6 ENSMUST00000027675.7 ENSMUST00000027675.8 ENSMUST00000027675.9 NM_011082 O70570 PIGR_MOUSE uc011wrk.1 uc011wrk.2 [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells. Interacts (mainly via CDR1-like domain) with dimeric IgA. Interacts (mainly via CDR2-like domain) with pentameric IgM. [Secretory component]: Either free or part of the secretory IgA (sIgA) complex that consists of two, four or five IgA monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteolytic product of PIGR). Free secretory component interacts with bacterial antigens toxA of C. difficile and eae of E. coli. [Polymeric immunoglobulin receptor]: Cell membrane ; Single-pass type I membrane protein [Secretory component]: Secreted The Ig-like V-type 1/D1 domain contains three complementarity determining region-like loops CDR1-3, which mediate interaction with IgA and IgM. N-glycosylated. N-glycosylation is required for anchoring IgA molecules to mucus, but is not necessary for Ig binding. detection of chemical stimulus involved in sensory perception of bitter taste polymeric immunoglobulin receptor activity immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor epidermal growth factor receptor binding extracellular region extracellular space plasma membrane epidermal growth factor receptor signaling pathway membrane integral component of membrane transport vesicle Fc receptor signaling pathway receptor clustering receptor complex recycling endosome membrane uc011wrk.1 uc011wrk.2 
ENSMUST00000027682.9 Gpr37l1 ENSMUST00000027682.9 G protein-coupled receptor 37-like 1 (from RefSeq NM_134438.3) ENSMUST00000027682.1 ENSMUST00000027682.2 ENSMUST00000027682.3 ENSMUST00000027682.4 ENSMUST00000027682.5 ENSMUST00000027682.6 ENSMUST00000027682.7 ENSMUST00000027682.8 Etbrlp2 G37L1_MOUSE NM_134438 O88313 Q80UB9 Q99JG1 Q99JG2 uc007csv.1 uc007csv.2 uc007csv.3 uc007csv.4 G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (PubMed:24062445). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (PubMed:29625592). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl- D-aspartate receptor activity (PubMed:28795439). Interacts with the PTCH1 receptor. Cell membrane ulti-pass membrane protein Cell projection, cilium membrane ; Multi-pass membrane protein Note=Associates with the basal membrane of Bergmann glia cell primary cilia. Highly expressed in brain but not in heart or kidney (at protein level) (PubMed:29625592). In the brain, highly expressed in cerebellar Bergmann glia (at protein level) (PubMed:24062445, PubMed:29625592). Detected in the hippocampus but not in the brain stem or neocortex (at protein level) (PubMed:29625592). In several key cardiovascular centers of the central nervous system including the caudal and rostral ventrolateral medulla, the nucleus of the solitary tract, and the A5 nucleus, detected close to, but not within, tyrosine hydroxylase-positive catecholaminergic neurons (at protein level) (PubMed:29625592). Expressed in astrocytes in both gray and white matter and is also detected throughout the brain in some oligodendrocyte precursors (PubMed:28795439). At postnatal day 1, not detectable in any brain area examined but at postnatal day 8, strongly expressed in both astrocytes and oligodendrocyte precursors (OPs). At postnatal day 15 and during adulthood, expression in astrocytes and OPs remains at high levels. The N-terminal region is required for constitutive signal transduction. Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity. Ubiquitinated. Premature down-regulation of proliferation of cerebellar granule neuron precursors in postnatal mice, precocious maturation of Bergmann glia and Purkinje neurons, precocious juvenile motor abilities, and improved adult motor learning and coordination (PubMed:24062445). Early activation of the Shh pathway with increased levels of Shh, Smo and Ptch1 earlier in postnatal development than in wild-type mice (PubMed:24062445). Increased aortic diastolic, mean arterial and pulse pressures in females but not in males (PubMed:29625592). Males develop exacerbated left ventricular hypertrophy and evidence of heart failure when challenged with short- term angiotensin-2 infusion while females are protected from cardiac fibrosis (PubMed:29625592). Increased susceptibility to induced seizures (PubMed:28688853). Reduced signaling in the cerebellum as indicated by significantly less cAMP production (PubMed:27072655). No effect on the input resistance or resting potential of astrocytes or neurons (PubMed:28795439). Neuronal death is increased by 40% in an in vitro model of ischemia (PubMed:28795439). Belongs to the G-protein coupled receptor 1 family. Has been reported to act as a receptor for prosaposin (PSAP). However, it has also been shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor. Sequence=BAA32062.1; Type=Erroneous initiation; Evidence=; negative regulation of systemic arterial blood pressure G-protein coupled receptor activity protein binding plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane positive regulation of cerebellar granule cell precursor proliferation prosaposin receptor activity peptide binding cell projection receptor complex positive regulation of MAPK cascade negative regulation of neuron differentiation negative regulation of smoothened signaling pathway negative regulation of astrocyte differentiation ciliary membrane negative regulation of hydrogen peroxide-induced cell death uc007csv.1 uc007csv.2 uc007csv.3 uc007csv.4 
ENSMUST00000027684.11 Arl8a ENSMUST00000027684.11 ADP-ribosylation factor-like 8A (from RefSeq NM_026823.2) ARL8A_MOUSE Arl10b ENSMUST00000027684.1 ENSMUST00000027684.10 ENSMUST00000027684.2 ENSMUST00000027684.3 ENSMUST00000027684.4 ENSMUST00000027684.5 ENSMUST00000027684.6 ENSMUST00000027684.7 ENSMUST00000027684.8 ENSMUST00000027684.9 Gie2 NM_026823 Q8VEH3 Q99KS1 Q9CTB0 uc007csu.1 uc007csu.2 uc007csu.3 Plays a role in lysosomes motility (PubMed:30174114). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (PubMed:30174114). May play a role in chromosome segregation (By similarity). Interacts with PLEKHM1. Late endosome membrane Lysosome membrane Cytoplasm, cytoskeleton, spindle Cell projection, axon Synapse Note=Localizes with microtubules at the spindle mid-zone during mitosis. Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTP binding cytoplasm lysosome lysosomal membrane endosome vacuolar membrane spindle cytoskeleton cell cycle chromosome segregation anterograde axonal transport protein transport membrane cell junction axon midbody late endosome membrane cell projection synapse spindle midzone cell division axon cytoplasm uc007csu.1 uc007csu.2 uc007csu.3 
ENSMUST00000027687.8 Ube2t ENSMUST00000027687.8 ubiquitin-conjugating enzyme E2T, transcript variant 1 (from RefSeq NM_026024.3) ENSMUST00000027687.1 ENSMUST00000027687.2 ENSMUST00000027687.3 ENSMUST00000027687.4 ENSMUST00000027687.5 ENSMUST00000027687.6 ENSMUST00000027687.7 NM_026024 Q9CQ37 UBE2T_MOUSE uc007csp.1 uc007csp.2 uc007csp.3 uc007csp.4 uc007csp.5 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence= Protein modification; protein ubiquitination. Interacts with FANCL and BRCA1. Nucleus Note=Accumulates to chromatin. Auto-ubiquitinated. Effects of auto-monoubiquitination at Lys-91 and Lys-181 are unclear. Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding chromatin binding ubiquitin-protein transferase activity ATP binding nucleus nucleolus DNA repair protein monoubiquitination cellular response to DNA damage stimulus protein ubiquitination transferase activity ubiquitin protein ligase binding protein K29-linked ubiquitination protein K27-linked ubiquitination protein autoubiquitination ubiquitin conjugating enzyme activity protein K63-linked ubiquitination protein K48-linked ubiquitination protein K11-linked ubiquitination protein K6-linked ubiquitination uc007csp.1 uc007csp.2 uc007csp.3 uc007csp.4 uc007csp.5 
ENSMUST00000027688.15 Rassf5 ENSMUST00000027688.15 Ras association (RalGDS/AF-6) domain family member 5, transcript variant 1 (from RefSeq NM_018750.4) ENSMUST00000027688.1 ENSMUST00000027688.10 ENSMUST00000027688.11 ENSMUST00000027688.12 ENSMUST00000027688.13 ENSMUST00000027688.14 ENSMUST00000027688.2 ENSMUST00000027688.3 ENSMUST00000027688.4 ENSMUST00000027688.5 ENSMUST00000027688.6 ENSMUST00000027688.7 ENSMUST00000027688.8 ENSMUST00000027688.9 NM_018750 Nore1 O70407 Q5EBH1 Q6KAR0 Q8C2E8 RASF5_MOUSE Rapl uc007cnd.1 uc007cnd.2 uc007cnd.3 Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. Interacts directly with activated HRAS; a RASSF5-STK4/MST1 complex probably associates with activated HRAS (PubMed:9488663, PubMed:11857081, PubMed:11864565, PubMed:18596699). Interacts with KRAS (PubMed:11857081, PubMed:11864565). Probably interacts with Ras-like GTPases RRAS, MRAS, RAP1B, RAP2A and RALA (PubMed:11857081). Interacts with RRAS2 (By similarity). Can self-associate (PubMed:11857081). Interacts with RSSF1 isoform A (PubMed:11857081). The RSSF1 isoform A- RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS (PubMed:11864565, PubMed:11857081). Isoform 2 interacts with activated RAP1A and ITGAL/LFA-1 (By similarity). Binds STK4/MST1, inhibiting STK4/MST1 autoactivation (PubMed:11864565). Q5EBH1; O88904: Hipk1; NbExp=5; IntAct=EBI-960530, EBI-692945; Q5EBH1; Q61411: Hras; NbExp=2; IntAct=EBI-960530, EBI-400273; Q5EBH1; P23804: Mdm2; NbExp=3; IntAct=EBI-960530, EBI-641788; Q5EBH1; Q9JI11: Stk4; NbExp=3; IntAct=EBI-960530, EBI-1181352; Q5EBH1; P01112: HRAS; Xeno; NbExp=13; IntAct=EBI-960530, EBI-350145; Q5EBH1; P62834: RAP1A; Xeno; NbExp=3; IntAct=EBI-960530, EBI-491414; Q5EBH1-1; P01112: HRAS; Xeno; NbExp=3; IntAct=EBI-960543, EBI-350145; Cytoplasm Cytoplasm, cytoskeleton Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5EBH1-1; Sequence=Displayed; Name=2; IsoId=Q5EBH1-2; Sequence=VSP_019368, VSP_019369; Sequence=BAD21397.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding nucleus cytoplasm cytoskeleton microtubule apoptotic process signal transduction negative regulation of cell proliferation Ras GTPase binding positive regulation of protein ubiquitination intracellular signal transduction identical protein binding regulation of apoptotic process metal ion binding regulation of protein localization to nucleus uc007cnd.1 uc007cnd.2 uc007cnd.3 
ENSMUST00000027690.7 Avpr1b ENSMUST00000027690.7 arginine vasopressin receptor 1B (from RefSeq NM_011924.3) ENSMUST00000027690.1 ENSMUST00000027690.2 ENSMUST00000027690.3 ENSMUST00000027690.4 ENSMUST00000027690.5 ENSMUST00000027690.6 NM_011924 Q9WU02 V1BR_MOUSE V1br uc007cnl.1 uc007cnl.2 uc007cnl.3 Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. regulation of systemic arterial blood pressure by vasopressin G-protein coupled receptor activity vasopressin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane peptide hormone binding cellular response to hormone stimulus protein homodimerization activity positive regulation of vasoconstriction uc007cnl.1 uc007cnl.2 uc007cnl.3 
ENSMUST00000027693.8 Rab29 ENSMUST00000027693.8 RAB29, member RAS oncogene family, transcript variant 8 (from RefSeq NR_185301.1) E9QLQ7 E9QLQ7_MOUSE ENSMUST00000027693.1 ENSMUST00000027693.2 ENSMUST00000027693.3 ENSMUST00000027693.4 ENSMUST00000027693.5 ENSMUST00000027693.6 ENSMUST00000027693.7 NR_185301 Rab29 Rab7l1 uc007cnv.1 uc007cnv.2 uc007cnv.3 uc007cnv.4 uc007cnv.5 uc007cnv.6 The small GTPases Rab are key regulators in vesicle trafficking. Membrane ; Lipid- anchor ; Cytoplasmic side Belongs to the small GTPase superfamily. Rab family. positive regulation of receptor recycling GTPase activity GTP binding cytoplasm mitochondrion early endosome Golgi apparatus cis-Golgi network trans-Golgi network cytosol mitochondrion organization Golgi organization synapse assembly response to bacterium negative regulation of neuron projection development vesicle-mediated transport Rab GTPase binding GDP binding kinesin binding symbiont-containing vacuole vesicle viral RNA genome replication T cell activation retrograde transport, endosome to Golgi positive regulation of T cell receptor signaling pathway recycling endosome dynein complex binding protein localization to membrane positive regulation of intracellular protein transport intracellular vesicle regulation of retrograde transport, endosome to Golgi multi-organism toxin transport uc007cnv.1 uc007cnv.2 uc007cnv.3 uc007cnv.4 uc007cnv.5 uc007cnv.6 
ENSMUST00000027697.12 Cdk18 ENSMUST00000027697.12 cyclin dependent kinase 18 (from RefSeq NM_008795.2) Cdk18 ENSMUST00000027697.1 ENSMUST00000027697.10 ENSMUST00000027697.11 ENSMUST00000027697.2 ENSMUST00000027697.3 ENSMUST00000027697.4 ENSMUST00000027697.5 ENSMUST00000027697.6 ENSMUST00000027697.7 ENSMUST00000027697.8 ENSMUST00000027697.9 NM_008795 Pctk3 Q0VDL6 Q0VDL6_MOUSE uc007coh.1 uc007coh.2 uc007coh.3 uc007coh.4 Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation kinase activity phosphorylation uc007coh.1 uc007coh.2 uc007coh.3 uc007coh.4 
ENSMUST00000027706.4 Lrrn2 ENSMUST00000027706.4 leucine rich repeat protein 2, neuronal (from RefSeq NM_010732.4) ENSMUST00000027706.1 ENSMUST00000027706.2 ENSMUST00000027706.3 Lrrn2 NM_010732 Q6PHP6 Q6PHP6_MOUSE uc007cpi.1 uc007cpi.2 uc007cpi.3 uc007cpi.4 molecular_function extracellular space membrane integral component of membrane extracellular matrix uc007cpi.1 uc007cpi.2 uc007cpi.3 uc007cpi.4 
ENSMUST00000027725.11 Klhl12 ENSMUST00000027725.11 kelch-like 12, transcript variant 8 (from RefSeq NM_001421136.1) C3ip1 ENSMUST00000027725.1 ENSMUST00000027725.10 ENSMUST00000027725.2 ENSMUST00000027725.3 ENSMUST00000027725.4 ENSMUST00000027725.5 ENSMUST00000027725.6 ENSMUST00000027725.7 ENSMUST00000027725.8 ENSMUST00000027725.9 KLH12_MOUSE NM_001421136 Q8BZM0 Q8K225 uc007csb.1 uc007csb.2 uc007csb.3 uc007csb.4 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export. As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins. Protein modification; protein ubiquitination. Component of the BCR(KLHL12) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A. Interacts with DRD4, KLHL2 and SEC31A. Interacts with PEF1 and PDCD6/ALG-2; interaction takes place in response to cytosolic calcium increase and leads to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B). Cytoplasmic vesicle, COPII-coated vesicle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZM0-1; Sequence=Displayed; Name=2; IsoId=Q8BZM0-2; Sequence=VSP_018280; The BTB domain is required for interaction with CUL3. Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome: ubiquitination by the SCF(FBXL17) complex takes place when aberrant BTB domain dimers are formed. Golgi membrane microtubule organizing center protein monoubiquitination ER to Golgi vesicle-mediated transport neural crest formation neural crest cell development Wnt signaling pathway vesicle-mediated transport protein ubiquitination COPII vesicle coat ER to Golgi transport vesicle cytoplasmic vesicle Cul3-RING ubiquitin ligase complex identical protein binding intracellular membrane-bounded organelle COPII vesicle coating uc007csb.1 uc007csb.2 uc007csb.3 uc007csb.4 
ENSMUST00000027726.14 Cyb5r1 ENSMUST00000027726.14 cytochrome b5 reductase 1, transcript variant 1 (from RefSeq NM_028057.3) ENSMUST00000027726.1 ENSMUST00000027726.10 ENSMUST00000027726.11 ENSMUST00000027726.12 ENSMUST00000027726.13 ENSMUST00000027726.2 ENSMUST00000027726.3 ENSMUST00000027726.4 ENSMUST00000027726.5 ENSMUST00000027726.6 ENSMUST00000027726.7 ENSMUST00000027726.8 ENSMUST00000027726.9 NB5R1_MOUSE NM_028057 Nqo3a2 Q91W81 Q9DB73 uc007cru.1 uc007cru.2 uc007cru.3 NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Reaction=2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+); Xref=Rhea:RHEA:46680, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.2.2; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DB73-1; Sequence=Displayed; Name=2; IsoId=Q9DB73-2; Sequence=VSP_025557, VSP_025558; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. cytochrome-b5 reductase activity, acting on NAD(P)H mitochondrion lipid metabolic process steroid biosynthetic process steroid metabolic process membrane integral component of membrane sterol biosynthetic process oxidoreductase activity oxidation-reduction process FAD binding uc007cru.1 uc007cru.2 uc007cru.3 
ENSMUST00000027727.15 Adipor1 ENSMUST00000027727.15 adiponectin receptor 1, transcript variant 2 (from RefSeq NM_028320.4) Adipor1 ENSMUST00000027727.1 ENSMUST00000027727.10 ENSMUST00000027727.11 ENSMUST00000027727.12 ENSMUST00000027727.13 ENSMUST00000027727.14 ENSMUST00000027727.2 ENSMUST00000027727.3 ENSMUST00000027727.4 ENSMUST00000027727.5 ENSMUST00000027727.6 ENSMUST00000027727.7 ENSMUST00000027727.8 ENSMUST00000027727.9 NM_028320 PAQR1_MOUSE Parq1 Q91VH1 Q9CZA0 uc007crx.1 uc007crx.2 uc007crx.3 uc007crx.4 This gene encodes a receptor for the fat-derived hormone adiponectin. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17327425, PubMed:17268472, PubMed:24742672). Required for normal glucose and fat homeostasis and for maintaining a normal body weight (PubMed:17327425, PubMed:24742672). ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis (PubMed:12802337, PubMed:17327425, PubMed:17268472, PubMed:24742672). Has high affinity for globular adiponectin and low affinity for full-length adiponectin (PubMed:12802337). May form homooligomers and heterooligomers with ADIPOR2 (By similarity). Interacts with APPL2 (via BAR domain); hinders the accessibility of APPL1 to ADIPOR1; negatively regulates adiponectin signaling; ADIPOQ dissociates this interaction and facilitates the recruitment of APPL1 to ADIPOR1 (PubMed:19661063). Interacts with APPL1; ADIPOQ enhances this interaction; inhibites adiponectin- stimulated binding of APPL2 to ADIPOR1 (PubMed:19661063). Q91VH1; Q9UKG1: APPL1; Xeno; NbExp=3; IntAct=EBI-992398, EBI-741243; Cell membrane ; Multi-pass membrane protein Note=Localized to the cell membrane and intracellular organelles. Detected in brain and quadriceps muscle (at protein level) (PubMed:17327425). Widely expressed (PubMed:12802337). Expressed in heart, kidney, liver, lung, skeletal muscle, white adipose tissue, brown adipose tissue, aorta and spleen (PubMed:12802337, PubMed:24742672). Weakly expressed in brain and testis (PubMed:12802337). The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane. Mutant mice are viable and fertile, but display defects in glucose and lipid homeostasis. The precise phenotype may depend on experimental details and genetic background. Mutant mice have normal body weight, but increased plasma glucose and insulin levels (PubMed:17268472). Mutant male mice, but not female mice, display increased body weight gain on standard chow, in spite of similar food intake as wild-type (PubMed:17327425). Mutant mice display increased body weight, both on standard chow and on high fat and high sucrose diet (PubMed:24742672). Male mice have increased total body fat mass after 15 weeks, and have increased weights of both white and brown adipose tissue (PubMed:17327425, PubMed:24742672). Mutant mice have impaired glucose tolerance (PubMed:24742672). Male mice have decreased glucose tolerance, but no significant change in the insulin response (PubMed:17327425). Female mice display increased fasting glucose levels, but unchanged fasting insulin levels (PubMed:17327425). Male and female mice display increased levels of liver triglycerides relative to wild-type (PubMed:17327425, PubMed:24742672). Male mice display decreased locomotor activity and decreased energy expenditure relative to wild-type (PubMed:17327425). Mutant mice display normal revascularization after chronic limb ischemia caused by severing of blood vessels (PubMed:24742672). Hepatocytes from mice lacking both Adipor1 and Adipor2 show loss of adiponectin binding and lack of adiponectin-mediated activation of AMPK and Ppara (PubMed:17268472). Mice lacking both Adipor1 and Adipor2 display elevated glucose and insulin levels in blood plasma, indicative of glucose intolerance and insulin resistance (PubMed:17268472). Belongs to the ADIPOR family. Sequence=BAB28509.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAB28509.1; Type=Frameshift; Note=This frameshift abolishes the stop codon.; Evidence=; protein binding plasma membrane lipid metabolic process fatty acid metabolic process hormone-mediated signaling pathway negative regulation of epithelial cell migration negative regulation of epithelial to mesenchymal transition regulation of glucose metabolic process membrane integral component of membrane regulation of lipid metabolic process fatty acid oxidation protein kinase binding negative regulation of cell growth intrinsic component of plasma membrane leptin-mediated signaling pathway adiponectin-activated signaling pathway signaling receptor activity glucose homeostasis identical protein binding negative regulation of JAK-STAT cascade positive regulation of JAK-STAT cascade positive regulation of insulin receptor signaling pathway metal ion binding protein heterodimerization activity adiponectin binding adipokinetic hormone receptor activity negative regulation of NIK/NF-kappaB signaling uc007crx.1 uc007crx.2 uc007crx.3 uc007crx.4 
ENSMUST00000027730.6 Myog ENSMUST00000027730.6 myogenin (from RefSeq NM_031189.2) ENSMUST00000027730.1 ENSMUST00000027730.2 ENSMUST00000027730.3 ENSMUST00000027730.4 ENSMUST00000027730.5 MYOG_MOUSE NM_031189 P12979 uc007crl.1 uc007crl.2 uc007crl.3 uc007crl.4 Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin- remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts. Homodimer and heterodimer with E12; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Interacts with SMARCA4/BRG1/BAF190A. Interacts (via C-terminal region) with SSRP1 and SUPT16H; the interaction is indicative of an interaction with the FACT complex. nteracts with CSRP3 (By similarity). P12979; Q60929: Mef2a; NbExp=2; IntAct=EBI-7132875, EBI-2639094; Nucleus te=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos. Expressed in myoblast cells. Expressed weakly in myotubes (at protein level). Expressed strongly in denervated muscles and in satellite cells isolated from denervated muscles. Expressed weakly in innervated muscle and in satellite cells isolated from innervated muscles. Expressed in the myotome of the somites at 8.5 dpc, onward (at protein level). Expressed in proximal region of both the hindlimb and the forelimb at 11.5 dpc, onward. Expressed during muscle maturation between 15 and 17 dpc and decreases thereafter. Not detected within the heart. Up-regulated in denervated muscles (at protein level). Up- regulated during myogenesis in the embryo and in cell culture models of myogenic differentiation via the p38 MAPK signaling pathway. Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles (By similarity). Display normal myoblast formation during embryogenesis, but show perinatal lethality because of a deficiency during the later stages of skeletal muscle fiber formation. Show no abnormalities for smooth muscles and cardiocytes differentiation. Conditional mutant with expression abrogated in muscle cells from 15.5 or 17.5 dpc are viable, fertil and exhibit no noticeable muscle growth and reduction of myofiber diameter defects but show smaller body size and mass. Conditional mutant in muscle cells of denervated hindlimb muscles show an inhibition of the denervation-dependent reductions in mass, force and atrophy of slow fiber-type soleus muscles, without increased in satellite cell proliferation and fusion. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ossification DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated cell cycle multicellular organism development muscle organ development skeletal muscle tissue development negative regulation of cell proliferation positive regulation of myotube differentiation positive regulation of muscle atrophy regulation of skeletal muscle satellite cell proliferation response to muscle activity involved in regulation of muscle adaptation response to electrical stimulus involved in regulation of muscle adaptation striated muscle atrophy response to denervation involved in regulation of muscle adaptation myotube differentiation cell differentiation chromatin DNA binding protein-DNA complex skeletal muscle cell differentiation mRNA transcription from RNA polymerase II promoter sequence-specific DNA binding positive regulation of myoblast differentiation negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity skeletal muscle fiber development positive regulation of skeletal muscle fiber development E-box binding positive regulation of cell cycle arrest cellular response to lithium ion cellular response to tumor necrosis factor cellular response to growth factor stimulus cellular response to estradiol stimulus regulation of myoblast fusion positive regulation of myoblast fusion positive regulation of oxidative phosphorylation histone H3 acetylation histone H4 acetylation uc007crl.1 uc007crl.2 uc007crl.3 uc007crl.4 
ENSMUST00000027740.14 Lhx4 ENSMUST00000027740.14 LIM homeobox protein 4 (from RefSeq NM_010712.2) ENSMUST00000027740.1 ENSMUST00000027740.10 ENSMUST00000027740.11 ENSMUST00000027740.12 ENSMUST00000027740.13 ENSMUST00000027740.2 ENSMUST00000027740.3 ENSMUST00000027740.4 ENSMUST00000027740.5 ENSMUST00000027740.6 ENSMUST00000027740.7 ENSMUST00000027740.8 ENSMUST00000027740.9 Gsh-4 Gsh4 LHX4_MOUSE NM_010712 O08916 P53776 Q810K7 Q9R280 uc007dbn.1 uc007dbn.2 uc007dbn.3 uc007dbn.4 uc007dbn.5 May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (By similarity). Nucleus Transient expression in ventrolateral regions of the developing neural tube and hindbrain. Sequence=AAD30125.1; Type=Erroneous initiation; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding placenta development DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated motor neuron axon guidance methyl-CpG binding animal organ morphogenesis medial motor column neuron differentiation neuron differentiation negative regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc007dbn.1 uc007dbn.2 uc007dbn.3 uc007dbn.4 uc007dbn.5 
ENSMUST00000027741.12 Xpr1 ENSMUST00000027741.12 xenotropic and polytropic retrovirus receptor 1 (from RefSeq NM_011273.2) ENSMUST00000027741.1 ENSMUST00000027741.10 ENSMUST00000027741.11 ENSMUST00000027741.2 ENSMUST00000027741.3 ENSMUST00000027741.4 ENSMUST00000027741.5 ENSMUST00000027741.6 ENSMUST00000027741.7 ENSMUST00000027741.8 ENSMUST00000027741.9 NM_011273 Q3UHG6 Q3UR99 Q8CCC8 Q8CCT2 Q9QZ72 Q9R034 Q9R036 Q9Z0U0 S53A1_MOUSE Syg1 Xpr1 uc007dbf.1 uc007dbf.2 uc007dbf.3 Inorganic ion transporter that mediates phosphate ion export across plasma membrane. Plays a major role in phosphate homeostasis, preventing intracellular phosphate accumulation and possible calcium phosphate precipitation, ultimately preserving calcium signaling. The molecular mechanism of phosphate transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (PubMed:32826297) (By similarity). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho- inositol pentakisphosphate (5-InsP7), important intracellular signaling molecules involved in regulation of phosphate flux (By similarity). (Microbial infection) Receptor for xenotropic and polytropic murine leukemia (X- and P-MLV) retroviruses. Confers susceptibility to X- or P-MLV infection in vitro. Reaction=phosphate(in) = phosphate(out); Xref=Rhea:RHEA:32823, ChEBI:CHEBI:43474; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32824; Evidence=; Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z0U0-1; Sequence=Displayed; Name=2; IsoId=Q9Z0U0-2; Sequence=VSP_030749; Expressed in pancreatic islets. The SPX domain has high affinity for inositol polyphosphates, such as myo-inositol hexakisphosphate and 5-diphospho-myo-inositol pentakisphosphate (5-InsP7). Its affinity for inorganic phosphate is tow to three orders of magnitude lower. Belongs to the SYG1 (TC 2.A.94) family. inositol hexakisphosphate binding virus receptor activity Golgi apparatus plasma membrane phosphate ion transport response to virus phosphate ion transmembrane transporter activity efflux transmembrane transporter activity membrane integral component of membrane cellular response to phosphate starvation cellular phosphate ion homeostasis intrinsic component of plasma membrane phosphate ion transmembrane transport viral entry into host cell uc007dbf.1 uc007dbf.2 uc007dbf.3 
ENSMUST00000027743.13 Stx6 ENSMUST00000027743.13 syntaxin 6 (from RefSeq NM_021433.3) ENSMUST00000027743.1 ENSMUST00000027743.10 ENSMUST00000027743.11 ENSMUST00000027743.12 ENSMUST00000027743.2 ENSMUST00000027743.3 ENSMUST00000027743.4 ENSMUST00000027743.5 ENSMUST00000027743.6 ENSMUST00000027743.7 ENSMUST00000027743.8 ENSMUST00000027743.9 NM_021433 Q9D3A1 Q9D729 Q9JKK1 STX6_MOUSE uc007dbb.1 uc007dbb.2 uc007dbb.3 SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Identified in a complex containing STX6, STX12 and VAMP4 (By similarity). This complex also includes VTI1A (PubMed:9705316). Binds EEA1 (By similarity). Interacts with VPS45A and GOPC (By similarity). Interacts with MARCHF2; the interaction promotes MARCHF2-mediated ubiquitination and degradation of CFTR (By similarity). Interacts with MARCHF3 (By similarity). Interacts with BLTP3B (via C-terminal coiled- coil domain) (PubMed:35499567). Interacts with BAIAP3; this interaction is increased in the presence of calcium (By similarity). Interacts with VPS13B (By similarity). Golgi apparatus membrane ; Single-pass type IV membrane protein Golgi apparatus, trans-Golgi network membrane ; Single-pass type IV membrane protein Recycling endosome membrane ; Single-pass type IV membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JKK1-1; Sequence=Displayed; Name=2; IsoId=Q9JKK1-2; Sequence=VSP_016138; Belongs to the syntaxin family. Golgi membrane SNARE binding SNAP receptor activity protein binding nucleoplasm early endosome Golgi apparatus trans-Golgi network cytosol intracellular protein transport vesicle fusion endosome organization synaptic vesicle endomembrane system protein transport membrane integral component of membrane synaptic vesicle to endosome fusion vesicle-mediated transport syntaxin binding integral component of synaptic vesicle membrane SNARE complex endocytic recycling trans-Golgi network membrane regulation of protein localization retrograde transport, endosome to Golgi phagocytic vesicle Golgi vesicle transport vesicle docking perinuclear region of cytoplasm recycling endosome Golgi ribbon formation regulation of cellular protein localization uc007dbb.1 uc007dbb.2 uc007dbb.3 
ENSMUST00000027744.10 Mr1 ENSMUST00000027744.10 major histocompatibility complex, class I-related, transcript variant 1 (from RefSeq NM_008209.5) ENSMUST00000027744.1 ENSMUST00000027744.2 ENSMUST00000027744.3 ENSMUST00000027744.4 ENSMUST00000027744.5 ENSMUST00000027744.6 ENSMUST00000027744.7 ENSMUST00000027744.8 ENSMUST00000027744.9 HMR1_MOUSE Mr1a NM_008209 O19478 Q8HWB0 uc007day.1 uc007day.2 uc007day.3 Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (PubMed:20581831, PubMed:15802267). Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D- ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D- ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D- ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively. May present microbial antigens to various TRAV1-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin. Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity). During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (PubMed:12634786, PubMed:31113973). Acts as an immune sensor of cancer cell metabolome. May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity). Heterotrimer that consists of MR1, B2M and metabolite antigen (By similarity). Forms reversible covalent Schiff base complexes with the microbial metabolite, which serve as a molecular switch triggering complete folding, stable association with B2M and translocation of the ternary complex from endoplasmic reticulum to the plasma membrane (By similarity). On antigen-presenting cells, the ternary complex interacts with TCR on CD8-positive T cells (By similarity). The molecular machinery involved in antigen processing remains unknown, but appears to be TAP1-TAP2 and proteasome-independent. Structurally, MR1-B2M heterodimer adopts a topology similar to classical MHC class I molecules, with alpha-1 and alpha-2 domains of MR1 forming the antigen- binding cleft composed of two alpha-helices resting on a floor of 7- stranded anti-parallel beta-pleated sheet (By similarity). Cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single- pass type I membrane protein Golgi apparatus membrane ; Single-pass type I membrane protein Early endosome membrane ; Single-pass type I membrane protein Late endosome membrane ; Single-pass type I membrane protein Note=In the absence of antigen remains within the endoplasmic reticulum where it acts as a metabolite sensor. Antigen binding triggers trafficking of the ternary complex to the plasma membrane. After presentation, most of these complexes are rapidly internalized and degraded via endocytosis. A small subset recycles via endosomes back to the plasma membrane and may thus acquire and present new antigens that do not efficiently reach the endoplasmic reticulum. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Mr1a; IsoId=Q8HWB0-1; Sequence=Displayed; Name=2; IsoId=Q8HWB0-2; Sequence=VSP_034759; Highly expressed thymus. Expressed in liver, kidney, spleen, heart, brain, lung, skeletal muscle and testis. The alpha-1 domain is a structural part of antigen-binding cleft. The alpha-2 domain is a structural part of antigen-binding cleft. N-glycosylated. Mutant mice lack invariant MAIT cells due to impaired thymic selection. They show normal development of T, B and NK cells. MR1 is detected in an open versus folded conformation. Only the folded MR1 conformer activates MAIT cells. Belongs to the MHC class I family. Reported to be associated with components of the peptide- loading complex, TAPBP, CALR, CANX and PDIA3 (PubMed:12794138). This association in primary cells and its functional relevance is disputable, given that antigen presentation and MAIT cell activation is shown to be TAP1-TAP2 and proteasome-independent. cytokine production involved in immune response immune system process antigen processing and presentation of peptide antigen via MHC class I extracellular space endoplasmic reticulum plasma membrane immune response external side of plasma membrane membrane integral component of membrane interleukin-1 beta production interleukin-17 production MHC class I protein complex innate immune response defense response to Gram-negative bacterium uc007day.1 uc007day.2 uc007day.3 
ENSMUST00000027748.8 Rgs16 ENSMUST00000027748.8 regulator of G-protein signaling 16 (from RefSeq NM_011267.4) ENSMUST00000027748.1 ENSMUST00000027748.2 ENSMUST00000027748.3 ENSMUST00000027748.4 ENSMUST00000027748.5 ENSMUST00000027748.6 ENSMUST00000027748.7 NM_011267 Q542U0 Q542U0_MOUSE Rgs16 uc007dae.1 uc007dae.2 uc007dae.3 uc007dae.4 Membrane ; Lipid- anchor GTPase activator activity cytoplasm positive regulation of GTPase activity uc007dae.1 uc007dae.2 uc007dae.3 uc007dae.4 
ENSMUST00000027752.15 Lamc1 ENSMUST00000027752.15 laminin, gamma 1 (from RefSeq NM_010683.2) ENSMUST00000027752.1 ENSMUST00000027752.10 ENSMUST00000027752.11 ENSMUST00000027752.12 ENSMUST00000027752.13 ENSMUST00000027752.14 ENSMUST00000027752.2 ENSMUST00000027752.3 ENSMUST00000027752.4 ENSMUST00000027752.5 ENSMUST00000027752.6 ENSMUST00000027752.7 ENSMUST00000027752.8 ENSMUST00000027752.9 F8VQJ3 F8VQJ3_MOUSE Lamc1 NM_010683 uc007czu.1 uc007czu.2 Secreted, extracellular space, extracellular matrix, basement membrane Lacks conserved residue(s) required for the propagation of feature annotation. extracellular matrix structural constituent basement membrane laminin-1 complex cell adhesion cell migration extracellular matrix disassembly extracellular matrix hemidesmosome assembly substrate adhesion-dependent cell spreading macromolecular complex assembly uc007czu.1 uc007czu.2 
ENSMUST00000027753.13 Lamc2 ENSMUST00000027753.13 laminin, gamma 2 (from RefSeq NM_008485.3) ENSMUST00000027753.1 ENSMUST00000027753.10 ENSMUST00000027753.11 ENSMUST00000027753.12 ENSMUST00000027753.2 ENSMUST00000027753.3 ENSMUST00000027753.4 ENSMUST00000027753.5 ENSMUST00000027753.6 ENSMUST00000027753.7 ENSMUST00000027753.8 ENSMUST00000027753.9 G5E874 G5E874_MOUSE Lamc2 NM_008485 uc007czr.1 uc007czr.2 Secreted, extracellular space, extracellular matrix, basement membrane Lacks conserved residue(s) required for the propagation of feature annotation. laminin-2 complex extracellular space cell cortex positive regulation of cell proliferation membrane positive regulation of cell migration extracellular matrix perinuclear region of cytoplasm uc007czr.1 uc007czr.2 
ENSMUST00000027760.14 Rgl1 ENSMUST00000027760.14 ral guanine nucleotide dissociation stimulator,-like 1, transcript variant 4 (from RefSeq NM_016846.5) ENSMUST00000027760.1 ENSMUST00000027760.10 ENSMUST00000027760.11 ENSMUST00000027760.12 ENSMUST00000027760.13 ENSMUST00000027760.2 ENSMUST00000027760.3 ENSMUST00000027760.4 ENSMUST00000027760.5 ENSMUST00000027760.6 ENSMUST00000027760.7 ENSMUST00000027760.8 ENSMUST00000027760.9 NM_016846 Q60695 Q8VD09 RGL1_MOUSE Rgl uc007czh.1 uc007czh.2 uc007czh.3 This gene encodes a member of the Ras-like (Ral) -selective guanine nucleotide exchange factor (RalGEF) family of small GTPase activators which function both as downstream effectors of activated Ras GTPase and as regulators of certain Ral GTPases in the RalGEF - Ral GTPase signaling pathway. The encoded protein, like other RalGEFs, has an N-terminal ras exchanger motif domain, a catalytic CDC25 homology domain, and a C-terminal ras binding domain that stimulates guanine nucleotide exchange when bound to a Ral GTPase. RalGEF family members bridge the Ras and Ral signaling pathways and are thought to play a role in oncogenic transformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. Probable guanine nucleotide exchange factor. Interacts with Ras. guanyl-nucleotide exchange factor activity signal transduction small GTPase mediated signal transduction Ral guanyl-nucleotide exchange factor activity uc007czh.1 uc007czh.2 uc007czh.3 
ENSMUST00000027764.10 Trem4 ENSMUST00000027764.10 RIKEN cDNA A530064D06 gene, transcript variant 2 (from RefSeq NM_001113556.1) A530064D06Rik ENSMUST00000027764.1 ENSMUST00000027764.2 ENSMUST00000027764.3 ENSMUST00000027764.4 ENSMUST00000027764.5 ENSMUST00000027764.6 ENSMUST00000027764.7 ENSMUST00000027764.8 ENSMUST00000027764.9 NM_001113556 Q8C239 Q8C239_MOUSE Trem4 uc012auz.1 uc012auz.2 uc012auz.3 cell surface signaling receptor activity regulation of innate immune response uc012auz.1 uc012auz.2 uc012auz.3 
ENSMUST00000027766.13 Coq8a ENSMUST00000027766.13 coenzyme Q8A, transcript variant 1 (from RefSeq NM_023341.3) Adck3 COQ8A_MOUSE Cabc1 Coq8a ENSMUST00000027766.1 ENSMUST00000027766.10 ENSMUST00000027766.11 ENSMUST00000027766.12 ENSMUST00000027766.2 ENSMUST00000027766.3 ENSMUST00000027766.4 ENSMUST00000027766.5 ENSMUST00000027766.6 ENSMUST00000027766.7 ENSMUST00000027766.8 ENSMUST00000027766.9 NM_023341 Q60936 Q8K0M1 Q9D657 Q9DBR5 Q9JHR3 uc007dvy.1 uc007dvy.2 uc007dvy.3 Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:27499294). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (By similarity). Shows an unusual selectivity for binding ADP over ATP (By similarity). Autoinhibited by the N-terminal domain, containing the KxGQ motif, that completely occludes the typical substrate binding pocket. Nucleotide-binding relieves inhibition. Cofactor biosynthesis; ubiquinone biosynthesis. Homodimer; homodimerizes via its transmembrane region. Interacts with the multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Mitochondrion Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60936-1; Sequence=Displayed; Name=2; IsoId=Q60936-2; Sequence=VSP_022354; Present in various tissues (at protein level). Adopts an atypical protein kinase-like fold: while it adopts a core fold similar to that of well-characterized protein kinase-like domains, a number of features are positioned to inhibit the kinase activity: (1) an atypical AAAS motif in an alanine-rich (A-rich) loop that replaces the canonical glycine-rich (G-rich) nucleotide-binding loop and limits ATP binding by establishing an unusual selectivity for ADP and (2) an N-terminal domain, containing the KxGQ motif, that completely occludes the typical substrate binding pocket. Nucleotide- binding opens the substrate binding pocket and flips the active site from inside the hydrophobic core into a catalytically competent, solvent-exposed posture. Mice were born at the expected Mendelian frequency and do not show overt phenotype under normal conditions. They however develop a slowly progressive loss of coordination after birth and develop ataxia and seizures. Defects are due to dysfunctional cerebellar Purkinje cells and defective skeletal muscle. Mice display tissue-specific coenzyme Q deficiency: coenzyme Q levels are normal in younger mice but significantly and specifically reduced in skeletal muscle. However, normal coenzyme Q levels are observed in whole cerebella, suggesting that cerebellar Purkinje cells are specifically affected. Belongs to the protein kinase superfamily. ADCK protein kinase family. nucleotide binding ATP binding mitochondrion protein phosphorylation ubiquinone biosynthetic process membrane integral component of membrane kinase activity phosphorylation transferase activity extrinsic component of mitochondrial inner membrane ADP binding protein kinase activity uc007dvy.1 uc007dvy.2 uc007dvy.3 
ENSMUST00000027768.14 Ahctf1 ENSMUST00000027768.14 AT hook containing transcription factor 1 (from RefSeq NM_026375.2) B2RRC8 ELYS_MOUSE ENSMUST00000027768.1 ENSMUST00000027768.10 ENSMUST00000027768.11 ENSMUST00000027768.12 ENSMUST00000027768.13 ENSMUST00000027768.2 ENSMUST00000027768.3 ENSMUST00000027768.4 ENSMUST00000027768.5 ENSMUST00000027768.6 ENSMUST00000027768.7 ENSMUST00000027768.8 ENSMUST00000027768.9 Elys NM_026375 Q8BVJ5 Q8CJF7 Q8VD55 uc011wxn.1 uc011wxn.2 uc011wxn.3 Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis (By similarity). Has also been proposed to function as a transcription factor which may play a specific role in hematopoietic tissues (PubMed:11952839). Associates with the Nup107-160 subcomplex of the NPC. Chromosome, centromere, kinetochore Nucleus, nucleoplasm Nucleus, nuclear pore complex Nucleus matrix Cytoplasm Note=Localizes to the nuclear pore complex (NPC) throughout interphase. Localizes to the kinetochore from prophase, and this appears to require the Nup107-160 subcomplex of the NPC. Localizes to the periphery of chromatin from late anaphase (By similarity). Widely expressed with higher expression in testis, lung and kidney. Expressed in T-cells, B-cells and granulocytes in bone marrow. Expressed throughout the embryo at 3.5 dpc and 6.5 dpc. Higher expression is detected at 10.5 dpc nad then progressively decreases. Highly expressed in fetal hematopoietic tissues including liver, spleen and thymus. Expressed in the endothelium lining the dorsal aorta of 11.5 dpc embryos (at protein level). The N-terminus forms a highly conserved seven-bladed beta propeller decorated with long loops and mediates anchorage to the Nup107-160 subcomplex of the nuclear pore, synergistically with the central alpha domain. The disordered C-terminus is responsible for the interactions with chromatin (PubMed:23499022). Embryonic lethality before 7.5 dpc. Impaired proliferation of the inner cells of the blastocyst due at least in part to increased apoptosis. Belongs to the ELYS family. chromosome, centromeric region kinetochore condensed chromosome kinetochore chromatin DNA binding transcription factor activity, sequence-specific DNA binding nucleus nuclear pore nucleoplasm chromosome cytoplasm regulation of transcription, DNA-templated cell cycle multicellular organism development protein transport nuclear matrix hemopoiesis nuclear pore outer ring nuclear membrane regulation of cytokinesis mRNA transport nuclear pore complex assembly cell division uc011wxn.1 uc011wxn.2 uc011wxn.3 
ENSMUST00000027769.6 Tfb2m ENSMUST00000027769.6 transcription factor B2, mitochondrial, transcript variant 1 (from RefSeq NM_008249.6) ENSMUST00000027769.1 ENSMUST00000027769.2 ENSMUST00000027769.3 ENSMUST00000027769.4 ENSMUST00000027769.5 NM_008249 Q3TL26 Q61669 Q8BTJ2 TFB2M_MOUSE Tfb2m uc007dvl.1 uc007dvl.2 uc007dvl.3 S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (By similarity). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:15526033). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:15526033). Stimulates transcription independently of the methyltransferase activity (By similarity). Reaction=adenosine in rRNA + S-adenosyl-L-methionine = H(+) + N(6)- methyladenosine in rRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:58728, Rhea:RHEA-COMP:15198, Rhea:RHEA-COMP:15199, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; Evidence=; Homodimer. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT. In this complex TFAM recruits POLRMT to the promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM. Mitochondrion Ubiquitously expressed. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily. rRNA modification rRNA (adenine-N6,N6-)-dimethyltransferase activity transcription cofactor activity RNA binding mitochondrion mitochondrial matrix regulation of transcription, DNA-templated rRNA processing transcription from mitochondrial promoter transcription initiation from mitochondrial promoter methyltransferase activity rRNA methyltransferase activity transferase activity rRNA methylation methylation mitochondrial nucleoid positive regulation of transcription, DNA-templated uc007dvl.1 uc007dvl.2 uc007dvl.3 
ENSMUST00000027775.9 Efcab2 ENSMUST00000027775.9 EF-hand calcium binding domain 2 (from RefSeq NM_026626.3) DRC8_MOUSE Drc8 ENSMUST00000027775.1 ENSMUST00000027775.2 ENSMUST00000027775.3 ENSMUST00000027775.4 ENSMUST00000027775.5 ENSMUST00000027775.6 ENSMUST00000027775.7 ENSMUST00000027775.8 NM_026626 Q9CQ46 Q9CS07 uc007dve.1 uc007dve.2 uc007dve.3 uc007dve.4 Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Component of the nexin-dynein regulatory complex (N-DRC). Cytoplasm, cytoskeleton, flagellum axoneme Belongs to the DRC8 family. calcium ion binding cellular_component cytoplasm cytoskeleton cilium biological_process motile cilium cell projection uc007dve.1 uc007dve.2 uc007dve.3 uc007dve.4 
ENSMUST00000027777.12 Parp1 ENSMUST00000027777.12 poly (ADP-ribose) polymerase family, member 1 (from RefSeq NM_007415.3) Adprt1 ENSMUST00000027777.1 ENSMUST00000027777.10 ENSMUST00000027777.11 ENSMUST00000027777.2 ENSMUST00000027777.3 ENSMUST00000027777.4 ENSMUST00000027777.5 ENSMUST00000027777.6 ENSMUST00000027777.7 ENSMUST00000027777.8 ENSMUST00000027777.9 NM_007415 Parp1 Q921K2 Q921K2_MOUSE uc007dwi.1 uc007dwi.2 uc007dwi.3 Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA- COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54425; Evidence=; Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58225; Evidence=; Reaction=L-histidyl-[protein] + NAD(+) = H(+) + N(tele)-(ADP-D- ribosyl)-L-histidyl-[protein] + nicotinamide; Xref=Rhea:RHEA:72071, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:18085, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29979, ChEBI:CHEBI:57540, ChEBI:CHEBI:191398; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72072; Evidence=; Reaction=L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D- ribosyl)-L-seryl-[protein]; Xref=Rhea:RHEA:58232, Rhea:RHEA- COMP:9863, Rhea:RHEA-COMP:15091, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29999, ChEBI:CHEBI:57540, ChEBI:CHEBI:142556; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58233; Evidence=; Reaction=L-tyrosyl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D- ribosyl)-L-tyrosyl-[protein]; Xref=Rhea:RHEA:58236, Rhea:RHEA- COMP:10136, Rhea:RHEA-COMP:15092, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:46858, ChEBI:CHEBI:57540, ChEBI:CHEBI:142557; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58237; Evidence=; Reaction=NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H(+).; EC=2.4.2.30; Evidence= Interacts (when auto-poly-ADP-ribosylated) with AIFM1. Chromosome Nucleus Belongs to the ARTD/PARP family. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding NAD+ ADP-ribosyltransferase activity nucleus nuclear envelope transcription factor complex nucleolus cytoplasm mitochondrion double-strand break repair protein ADP-ribosylation apoptotic process cellular response to DNA damage stimulus mitochondrion organization transforming growth factor beta receptor signaling pathway transcription factor binding zinc ion binding response to gamma radiation positive regulation of cardiac muscle hypertrophy regulation of SMAD protein complex assembly protein autoprocessing transferase activity transferase activity, transferring glycosyl groups peptidyl-serine ADP-ribosylation peptidyl-glutamic acid poly-ADP-ribosylation enzyme binding protein kinase binding signal transduction involved in regulation of gene expression estrogen receptor binding DNA ADP-ribosylation mitochondrial DNA metabolic process cellular response to insulin stimulus macromolecular complex protein-DNA complex positive regulation of intracellular estrogen receptor signaling pathway cellular response to oxidative stress cellular response to UV site of double-strand break protein modification process DNA damage response, detection of DNA damage identical protein binding histone deacetylase binding mitochondrial DNA repair regulation of DNA methylation positive regulation of transcription from RNA polymerase II promoter SMAD binding protein N-terminus binding regulation of catalytic activity NAD binding positive regulation of mitochondrial depolarization positive regulation of SMAD protein import into nucleus protein poly-ADP-ribosylation protein auto-ADP-ribosylation R-SMAD binding cellular response to zinc ion cellular response to transforming growth factor beta stimulus positive regulation of protein localization to nucleus positive regulation of neuron death regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway positive regulation of single strand break repair regulation of cellular protein localization response to aldosterone cellular response to beta-amyloid positive regulation of myofibroblast differentiation positive regulation of double-strand break repair via homologous recombination protein ADP-ribosylase activity ATP generation from poly-ADP-D-ribose positive regulation of transcription regulatory region DNA binding negative regulation of ATP biosynthetic process uc007dwi.1 uc007dwi.2 uc007dwi.3 
ENSMUST00000027778.8 Mixl1 ENSMUST00000027778.8 Mix paired-like homeobox (from RefSeq NM_013729.3) ENSMUST00000027778.1 ENSMUST00000027778.2 ENSMUST00000027778.3 ENSMUST00000027778.4 ENSMUST00000027778.5 ENSMUST00000027778.6 ENSMUST00000027778.7 MIXL1_MOUSE Mix Mml NM_013729 Q9QZ61 Q9WUI0 uc007dwp.1 uc007dwp.2 uc007dwp.3 Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression. Q9WUI0; Q9WUI0: Mixl1; NbExp=2; IntAct=EBI-13637214, EBI-13637214; Q9WUI0; P20293: Tbxt; NbExp=7; IntAct=EBI-13637214, EBI-13637160; Nucleus Expressed in the primitive streak of the gastrulating embryo, and marks cells destined to form mesoderm and endoderm. Present in differentiating embryonic stem cells (at protein level). Initially expressed in visceral endoderm and becomes restricted to primitive streak and nascent mesoderm at gastrulation. This includes the hemangioblast, a precursor of hematopoietic and vascular stem cells. At 5.5 dpc, it is expressed symmetrically in the visceral endoderm but by 6.0 dpc this expression is noticeably asymmetric. At 6.5 dpc, expression is restricted to the nascent primitive streak and persists in the primitive streak through 7.5-9.5 dpc, marking those cells fated to form extra-embryonic and lateral mesoderm. By TGF-beta. Regulated by Nodal in mesendoderm morphogenesis. Regulated by FOXH1, which acts as a negative regulator by recruiting GSC to promoter during early development. Mice display defects in mesendoderm morphogenesis and patterning during development. Embryos show a marked thickening of the primitive streak. By the early somite stage, embryonic development is arrested, with the formation of abnormal head folds, foreshortened body axis, absence of heart tube and gut, deficient paraxial mesoderm, and an enlarged midline tissue mass that replaces the notochord. Development of extra-embryonic structures is generally normal except that the allantois is often disproportionately large for the size of the mutant embryo. Belongs to the paired homeobox family. nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor binding RNA polymerase II repressing transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding endoderm formation hematopoietic progenitor cell differentiation DNA binding protein binding nucleus regulation of transcription, DNA-templated multicellular organism development gastrulation endoderm development heart development hemopoiesis cell differentiation endodermal cell differentiation cell migration involved in gastrulation identical protein binding protein homodimerization activity sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter digestive tract development negative regulation of hematopoietic progenitor cell differentiation positive regulation of mesoderm development uc007dwp.1 uc007dwp.2 uc007dwp.3 
ENSMUST00000027780.6 Acbd3 ENSMUST00000027780.6 acyl-Coenzyme A binding domain containing 3 (from RefSeq NM_133225.3) A0A0R4J079 A0A0R4J079_MOUSE Acbd3 ENSMUST00000027780.1 ENSMUST00000027780.2 ENSMUST00000027780.3 ENSMUST00000027780.4 ENSMUST00000027780.5 NM_133225 uc007dwq.1 uc007dwq.2 uc007dwq.3 fatty-acyl-CoA binding Golgi membrane Golgi apparatus protein kinase A regulatory subunit binding uc007dwq.1 uc007dwq.2 uc007dwq.3 
ENSMUST00000027781.7 Cox20 ENSMUST00000027781.7 cytochrome c oxidase assembly protein 20 (from RefSeq NM_025511.2) COX20_MOUSE ENSMUST00000027781.1 ENSMUST00000027781.2 ENSMUST00000027781.3 ENSMUST00000027781.4 ENSMUST00000027781.5 ENSMUST00000027781.6 Fam36a NM_025511 Q8BT52 Q9D7J4 uc007duz.1 uc007duz.2 uc007duz.3 Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT- CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme. Found in a complex with TMEM177, COA6, MT-CO2/COX2, COX18, SCO1 and SCO2. Interacts with SCO1, SCO2 and COA6 in a MT-CO2/COX2- and COX18-dependent manner. Interacts with COX18 in a MT-CO2/COX2-dependent manner. Interacts with MT-CO2/COX2 and TMEM177. Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the COX20 family. molecular_function mitochondrion mitochondrial inner membrane membrane integral component of membrane mitochondrial respiratory chain complex IV assembly uc007duz.1 uc007duz.2 uc007duz.3 
ENSMUST00000027783.14 Desi2 ENSMUST00000027783.14 desumoylating isopeptidase 2 (from RefSeq NM_024282.3) DESI2_MOUSE ENSMUST00000027783.1 ENSMUST00000027783.10 ENSMUST00000027783.11 ENSMUST00000027783.12 ENSMUST00000027783.13 ENSMUST00000027783.2 ENSMUST00000027783.3 ENSMUST00000027783.4 ENSMUST00000027783.5 ENSMUST00000027783.6 ENSMUST00000027783.7 ENSMUST00000027783.8 ENSMUST00000027783.9 Fam152a NM_024282 Pppde1 Q3TUJ4 Q9D291 uc007dux.1 uc007dux.2 uc007dux.3 uc007dux.4 Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'- linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with RPS7. Cytoplasm Widely expressed. Belongs to the DeSI family. cytoplasm proteolysis peptidase activity hydrolase activity thiol-dependent ubiquitinyl hydrolase activity Lys63-specific deubiquitinase activity protein K63-linked deubiquitination protein K48-linked deubiquitination Lys48-specific deubiquitinase activity uc007dux.1 uc007dux.2 uc007dux.3 uc007dux.4 
ENSMUST00000027785.15 Sdccag8 ENSMUST00000027785.15 serologically defined colon cancer antigen 8, transcript variant 1 (from RefSeq NM_029756.3) Cccap ENSMUST00000027785.1 ENSMUST00000027785.10 ENSMUST00000027785.11 ENSMUST00000027785.12 ENSMUST00000027785.13 ENSMUST00000027785.14 ENSMUST00000027785.2 ENSMUST00000027785.3 ENSMUST00000027785.4 ENSMUST00000027785.5 ENSMUST00000027785.6 ENSMUST00000027785.7 ENSMUST00000027785.8 ENSMUST00000027785.9 NM_029756 Q80UF4 SDCG8_MOUSE uc007duj.1 uc007duj.2 uc007duj.3 uc007duj.4 Plays a role in the establishment of cell polarity and epithelial lumen formation (PubMed:20835237). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). Homodimer (PubMed:12559564). Interacts with OFD1; the interaction is direct (By similarity). Interacts with FAM161A (By similarity). Interacts with RABEP2, ERC1 and CEP131 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole toplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body Cell junction Note=Located at the distal ends of both centrioles and colocalizes to centrosomes throughout the cell cycle. Expressed in liver, kidney, spleen, brain, heart and muscle. Expressed in photoreceptor cells of the retina. In renal epithelial cells gene knockdown results in the formation of spheroids with architectural defects characterized by disturbed localization of beta-catenin (CTNNB1) at the basolateral membrane, fewer tight junctions and an irregular lumen (PubMed:20835237). SDCCAG8-deficient mice display developmental bone malformations with rib cage abnormalities. neuron migration protein binding cytoplasm centrosome centriole microtubule organizing center cytoskeleton cell-cell junction centrosome cycle establishment of cell polarity cell projection organization cell junction microtubule organizing center organization centriolar satellite tube formation ciliary basal body cell projection photoreceptor cell cilium regulation of cilium assembly uc007duj.1 uc007duj.2 uc007duj.3 uc007duj.4 
ENSMUST00000027792.6 Srp9 ENSMUST00000027792.6 signal recognition particle 9 (from RefSeq NM_012058.3) ENSMUST00000027792.1 ENSMUST00000027792.2 ENSMUST00000027792.3 ENSMUST00000027792.4 ENSMUST00000027792.5 NM_012058 Q5EAT0 Q5EAT0_MOUSE Srp9 uc007dxu.1 uc007dxu.2 uc007dxu.3 uc007dxu.4 Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. Cytoplasm Belongs to the SRP9 family. RNA binding cytoplasm signal recognition particle, endoplasmic reticulum targeting SRP-dependent cotranslational protein targeting to membrane 7S RNA binding negative regulation of translational elongation signal recognition particle uc007dxu.1 uc007dxu.2 uc007dxu.3 uc007dxu.4 
ENSMUST00000027795.14 Cnih3 ENSMUST00000027795.14 cornichon family AMPA receptor auxiliary protein 3, transcript variant 2 (from RefSeq NM_001160211.2) CNIH3_MOUSE ENSMUST00000027795.1 ENSMUST00000027795.10 ENSMUST00000027795.11 ENSMUST00000027795.12 ENSMUST00000027795.13 ENSMUST00000027795.2 ENSMUST00000027795.3 ENSMUST00000027795.4 ENSMUST00000027795.5 ENSMUST00000027795.6 ENSMUST00000027795.7 ENSMUST00000027795.8 ENSMUST00000027795.9 NM_001160211 Q14BS0 Q6ZWS4 uc007dxi.1 uc007dxi.2 uc007dxi.3 uc007dxi.4 Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization (By similarity). Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Postsynaptic cell membrane ; Multi- pass membrane protein Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). Belongs to the cornichon family. plasma membrane membrane integral component of membrane vesicle-mediated transport channel regulator activity cell junction AMPA glutamate receptor complex synaptic transmission, glutamatergic regulation of membrane potential dendritic shaft synapse postsynaptic membrane localization within membrane glutamatergic synapse neurotransmitter receptor localization to postsynaptic specialization membrane regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc007dxi.1 uc007dxi.2 uc007dxi.3 uc007dxi.4 
ENSMUST00000027797.9 Nvl ENSMUST00000027797.9 nuclear VCP-like (from RefSeq NM_026171.2) ENSMUST00000027797.1 ENSMUST00000027797.2 ENSMUST00000027797.3 ENSMUST00000027797.4 ENSMUST00000027797.5 ENSMUST00000027797.6 ENSMUST00000027797.7 ENSMUST00000027797.8 NM_026171 NVL_MOUSE Nvl Q3USC4 Q8BW27 Q8K2B5 Q9DBY8 uc007dxb.1 uc007dxb.2 uc007dxb.3 Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity. Interacts with NCL/nucleolin (PubMed:21474449). Isoform 1 and isoform 2 interact with TERT and isoform 1 exhibits a higher binding affinity for TERT compared to isoform 2. Isoform 1 interacts with MTREX in an ATP-dependent manner; the interaction is required to associate NVL with nuclear RNA exosome. Isoform 1 interacts with RPL5 in an ATP- dependent manner. Interacts with WDR74 (through WDR repeats); the interaction is independent of RNA or pre-60S ribosome particles (By similarity). Nucleus, nucleolus Nucleus, nucleoplasm Note=Associates with pre-ribosomal particles in the nucleus. Belongs to the AAA ATPase family. nucleotide binding nuclear exosome (RNase complex) ATP binding nucleus nucleoplasm telomerase holoenzyme complex nucleolus rRNA processing ATPase activity positive regulation of protein binding ribosome biogenesis ribosomal large subunit biogenesis positive regulation of telomerase activity regulation of protein localization to nucleolus preribosome binding uc007dxb.1 uc007dxb.2 uc007dxb.3 
ENSMUST00000027800.15 Tmem63a ENSMUST00000027800.15 transmembrane protein 63a, transcript variant 8 (from RefSeq NR_184529.1) CSCL1_MOUSE ENSMUST00000027800.1 ENSMUST00000027800.10 ENSMUST00000027800.11 ENSMUST00000027800.12 ENSMUST00000027800.13 ENSMUST00000027800.14 ENSMUST00000027800.2 ENSMUST00000027800.3 ENSMUST00000027800.4 ENSMUST00000027800.5 ENSMUST00000027800.6 ENSMUST00000027800.7 ENSMUST00000027800.8 ENSMUST00000027800.9 Kiaa0792 NR_184529 Q3TCS5 Q69ZZ1 Q91YT8 uc007dwx.1 uc007dwx.2 uc007dwx.3 Acts as an osmosensitive calcium-permeable cation channel (PubMed:27045885). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (PubMed:30382938). Lysosome membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Belongs to the CSC1 (TC 1.A.17) family. Sequence=BAD32305.1; Type=Erroneous initiation; Evidence=; Sequence=BAE41880.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; nucleic acid binding calcium activated cation channel activity lysosome lysosomal membrane microtubule organizing center plasma membrane ion transport membrane integral component of membrane ion transmembrane transport intracellular membrane-bounded organelle uc007dwx.1 uc007dwx.2 uc007dwx.3 
ENSMUST00000027802.9 Pycr2 ENSMUST00000027802.9 pyrroline-5-carboxylate reductase family, member 2 (from RefSeq NM_133705.2) ENSMUST00000027802.1 ENSMUST00000027802.2 ENSMUST00000027802.3 ENSMUST00000027802.4 ENSMUST00000027802.5 ENSMUST00000027802.6 ENSMUST00000027802.7 ENSMUST00000027802.8 NM_133705 P5CR2_MOUSE Q922Q4 uc007dwv.1 uc007dwv.2 uc007dwv.3 uc007dwv.4 Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity). Reaction=L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH; Xref=Rhea:RHEA:14109, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60039; EC=1.5.1.2; Evidence=; Reaction=L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:14105, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60039; EC=1.5.1.2; Evidence=; Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. Homodecamer; composed of 5 homodimers. Interacts with LTO1. Cytoplasm Mitochondrion Belongs to the pyrroline-5-carboxylate reductase family. pyrroline-5-carboxylate reductase activity cytoplasm mitochondrion proline biosynthetic process cellular amino acid biosynthetic process oxidoreductase activity cellular response to oxidative stress oxidation-reduction process L-proline biosynthetic process uc007dwv.1 uc007dwv.2 uc007dwv.3 uc007dwv.4 
ENSMUST00000027809.8 Opn3 ENSMUST00000027809.8 opsin 3 (from RefSeq NM_010098.4) ENSMUST00000027809.1 ENSMUST00000027809.2 ENSMUST00000027809.3 ENSMUST00000027809.4 ENSMUST00000027809.5 ENSMUST00000027809.6 ENSMUST00000027809.7 Ecpn NM_010098 OPN3_MOUSE Q3V0X3 Q9WUK7 uc007dtq.1 uc007dtq.2 uc007dtq.3 uc007dtq.4 G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin (PubMed:30284927). Binds both 11-cis retinal and all-trans retinal (By similarity). Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R-mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light (By similarity). Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling (By similarity). Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade (By similarity). Required for TYR and DCT blue light-induced complex formation in melanocytes (By similarity). Involved in keratinocyte differentiation in response to blue-light (By similarity). Required for the UVA- mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (By similarity). Plays a role in light- mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (PubMed:32040503). May be involved in photorelaxation of airway smooth muscle cells, via blue- light dependent GPCR signaling pathways (PubMed:30284927). Interacts with MC1R; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes. Cell membrane ; Multi-pass membrane protein Cytoplasm Expressed in the eye (at protein level) (PubMed:30284927). Expressed in tracheal airway smooth muscle (PubMed:30284927). Expressed in brown adipocyte tissue; expression becomes more abundant during differentiation (PubMed:32040503). Strongly expressed in brain (PubMed:10234000). Highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus (PubMed:10234000). Shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord (PubMed:10234000). Expressed at substantial levels in the dorsal pons at 18.5 dpc (PubMed:10234000). Expressed in Purkinje cells at P4, with expression becoming striped at P20 (PubMed:10234000). Expressed in the cerebral cortex from 18.5 dpc with a rostrocaudal gradient of expression becoming evident at P20 (PubMed:10234000). No visible phenotype (PubMed:32040503). Increased weight gain on a high fat diet, as a result of increased fat mass and increased insulin resistance (PubMed:32040503). Increased basal glucose uptake in brown adipocytes, potentially as a result of decreased GLUT1 expression (PubMed:32040503). Significantly reduced lipocytic rate, mitochondrial DNA expression and cytochrome C oxidase activity in brown adipocyte tissues (PubMed:32040503). Loss of light-mediated increase in glucose uptake, mitochondrial respiration, thermogenic capacity and lipid metabolism-related gene expression in brown adipocyte tissues (PubMed:32040503). Impaired maximum thermogenic capacity with reduced heat production and reduced oxygen consumption in response to norepinephrine treatment in brown adipocytes (PubMed:32040503). Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. photoreceptor outer segment G-protein coupled receptor activity integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway phototransduction G-protein coupled photoreceptor activity detection of visible light photoreceptor activity membrane integral component of membrane protein-chromophore linkage response to stimulus cellular response to light stimulus uc007dtq.1 uc007dtq.2 uc007dtq.3 uc007dtq.4 
ENSMUST00000027810.14 Fh1 ENSMUST00000027810.14 fumarate hydratase 1 (from RefSeq NM_010209.2) ENSMUST00000027810.1 ENSMUST00000027810.10 ENSMUST00000027810.11 ENSMUST00000027810.12 ENSMUST00000027810.13 ENSMUST00000027810.2 ENSMUST00000027810.3 ENSMUST00000027810.4 ENSMUST00000027810.5 ENSMUST00000027810.6 ENSMUST00000027810.7 ENSMUST00000027810.8 ENSMUST00000027810.9 FUMH_MOUSE Fh Fh1 NM_010209 P97807 Q3UIA9 Q99JL0 Q9DCX0 uc007dtn.1 uc007dtn.2 uc007dtn.3 uc007dtn.4 Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:23643539). Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Mitochondrial]: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate (PubMed:23643539). Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by- product of the urea cycle and amino-acid catabolism (PubMed:23643539). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (By similarity). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double- strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (By similarity). [Isoform Mitochondrial]: Reaction=(S)-malate = fumarate + H2O; Xref=Rhea:RHEA:12460, ChEBI:CHEBI:15377, ChEBI:CHEBI:15589, ChEBI:CHEBI:29806; EC=4.2.1.2; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:12462; Evidence=; [Isoform Cytoplasmic]: Reaction=(S)-malate = fumarate + H2O; Xref=Rhea:RHEA:12460, ChEBI:CHEBI:15377, ChEBI:CHEBI:15589, ChEBI:CHEBI:29806; EC=4.2.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12461; Evidence=; Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1. Homotetramer. Interacts with H2AZ1. [Isoform Mitochondrial]: Mitochondrion [Isoform Cytoplasmic]: Cytoplasm, cytosol Nucleus Chromosome Note=Translocates to the nucleus in response to DNA damage: localizes to DNA double-strand breaks (DSBs) following phosphorylation by PRKDC. Event=Alternative initiation; Named isoforms=2; Name=Mitochondrial; IsoId=P97807-1; Sequence=Displayed; Name=Cytoplasmic; IsoId=P97807-2; Sequence=VSP_018967; [Isoform Cytoplasmic]: Phosphorylation at Thr-233 by PRKDC in response to DNA damage promotes translocation to the nucleus and recruitment to DNA double-strand breaks (DSBs). Embryonic lethality (PubMed:17418408). Conditional deletion in the kidney leads to the development of renal cysts, reminiscent of hereditary leiomyomatosis and renal cell cancer (HLRCC) phenotype in human (PubMed:17418408). Renal cysts are caused by accumulation of fumarate that promotes the formation of non-enzymatic post-translational modification cysteine S-succination (S-(2- succinyl)cysteine) on proteins, such as Keap1 (PubMed:22014577). There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. urea cycle negative regulation of histone H3-K36 methylation regulation of arginine metabolic process catalytic activity fumarate hydratase activity nucleus chromosome cytoplasm mitochondrion cytosol tricarboxylic acid cycle fumarate metabolic process malate metabolic process DNA repair cellular response to DNA damage stimulus lyase activity site of double-strand break histone binding tricarboxylic acid cycle enzyme complex homeostasis of number of cells within a tissue positive regulation of double-strand break repair via nonhomologous end joining uc007dtn.1 uc007dtn.2 uc007dtn.3 uc007dtn.4 
ENSMUST00000027816.5 Mptx1 ENSMUST00000027816.5 mucosal pentraxin 1 (from RefSeq NM_025470.4) A0A0R4J077 A0A0R4J077_MOUSE ENSMUST00000027816.1 ENSMUST00000027816.2 ENSMUST00000027816.3 ENSMUST00000027816.4 Mptx1 NM_025470 uc007dsy.1 uc007dsy.2 uc007dsy.3 uc007dsy.4 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 calcium ions per subunit. ; Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Secreted Belongs to the pentraxin family. extracellular region metal ion binding uc007dsy.1 uc007dsy.2 uc007dsy.3 uc007dsy.4 
ENSMUST00000027817.8 Spta1 ENSMUST00000027817.8 spectrin alpha, erythrocytic 1 (from RefSeq NM_011465.4) B2RWX6 ENSMUST00000027817.1 ENSMUST00000027817.2 ENSMUST00000027817.3 ENSMUST00000027817.4 ENSMUST00000027817.5 ENSMUST00000027817.6 ENSMUST00000027817.7 NM_011465 P08032 P97502 SPTA1_MOUSE Spna1 Spta uc007dsw.1 uc007dsw.2 uc007dsw.3 uc007dsw.4 Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Composed of non-homologous chains, alpha and beta, which aggregate to form dimers, tetramers, and higher polymers. Interacts with FASLG (By similarity). Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. This complex is anchored to the cytoplasmic face of the plasma membrane via another protein, ankyrin, which binds to beta- spectrin and mediates the binding of the whole complex to a transmembrane protein band 3. The interaction of erythrocyte spectrin with other proteins through specific binding domains lead to the formation of an extensive subplasmalemmal meshwork which is thought to be responsible for the maintenance of the biconcave shape of human erythrocytes, for the regulation of plasma membrane components and for the maintenance of the lipid asymmetry of the plasma membrane. Belongs to the spectrin family. lymphocyte homeostasis actin binding calcium ion binding cytoplasm cytoskeleton cell cortex porphyrin-containing compound biosynthetic process plasma membrane organization spectrin regulation of cell shape cytoplasmic side of plasma membrane spectrin-associated cytoskeleton membrane actin cytoskeleton organization hemopoiesis axon cortical cytoskeleton positive regulation of protein binding cuticular plate positive regulation of T cell proliferation metal ion binding protein heterodimerization activity actin filament capping uc007dsw.1 uc007dsw.2 uc007dsw.3 uc007dsw.4 
ENSMUST00000027824.7 Apcs ENSMUST00000027824.7 amyloid P component, serum (from RefSeq NM_011318.3) Apcs ENSMUST00000027824.1 ENSMUST00000027824.2 ENSMUST00000027824.3 ENSMUST00000027824.4 ENSMUST00000027824.5 ENSMUST00000027824.6 NM_011318 Q4JFI8 Q4JFI8_MOUSE Sap uc007dqy.1 uc007dqy.2 uc007dqy.3 uc007dqy.4 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 calcium ions per subunit. ; Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. Secreted Belongs to the pentraxin family. complement component C1q binding calcium ion binding extracellular region extracellular space identical protein binding negative regulation by host of viral exo-alpha-sialidase activity negative regulation by host of viral glycoprotein metabolic process innate immune response negative regulation of monocyte differentiation negative regulation of viral entry into host cell virion binding metal ion binding negative regulation of viral process negative regulation of exo-alpha-sialidase activity negative regulation of glycoprotein metabolic process uc007dqy.1 uc007dqy.2 uc007dqy.3 uc007dqy.4 
ENSMUST00000027826.7 Dusp23 ENSMUST00000027826.7 dual specificity phosphatase 23 (from RefSeq NM_026725.3) DUS23_MOUSE ENSMUST00000027826.1 ENSMUST00000027826.2 ENSMUST00000027826.3 ENSMUST00000027826.4 ENSMUST00000027826.5 ENSMUST00000027826.6 Ldp3 NM_026725 Q6NT99 Q9CW48 uc007dqw.1 uc007dqw.2 uc007dqw.3 Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Cytoplasm, cytosol Nucleus Note=Mainly cytosolic. Weakly nuclear (By similarity). Widely expressed. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus nucleoplasm cytoplasm cytosol protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc007dqw.1 uc007dqw.2 uc007dqw.3 
ENSMUST00000027830.5 Slamf9 ENSMUST00000027830.5 SLAM family member 9 (from RefSeq NM_029612.4) A0A0R4J072 A0A0R4J072_MOUSE ENSMUST00000027830.1 ENSMUST00000027830.2 ENSMUST00000027830.3 ENSMUST00000027830.4 NM_029612 Slamf9 uc007dql.1 uc007dql.2 uc007dql.3 uc007dql.4 membrane integral component of membrane uc007dql.1 uc007dql.2 uc007dql.3 uc007dql.4 
ENSMUST00000027843.11 Fmo9 ENSMUST00000027843.11 flavin containing monooxygenase 9, transcript variant 1 (from RefSeq NM_172844.2) ENSMUST00000027843.1 ENSMUST00000027843.10 ENSMUST00000027843.2 ENSMUST00000027843.3 ENSMUST00000027843.4 ENSMUST00000027843.5 ENSMUST00000027843.6 ENSMUST00000027843.7 ENSMUST00000027843.8 ENSMUST00000027843.9 Fmo9 NM_172844 Q8C116 Q8C116_MOUSE uc007dkq.1 uc007dkq.2 Reaction=(2E)-geranial + H(+) + NADPH + O2 = (1E)-2,6- dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+); Xref=Rhea:RHEA:54860, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:138375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54861; Evidence=; Reaction=H(+) + NADPH + O2 + octan-3-one = H2O + NADP(+) + pentyl propanoate; Xref=Rhea:RHEA:54840, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:80946, ChEBI:CHEBI:87373; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54841; Evidence=; Reaction=H(+) + NADPH + O2 + octan-3-one = ethyl hexanoate + H2O + NADP(+); Xref=Rhea:RHEA:54856, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:80946, ChEBI:CHEBI:86055; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54857; Evidence=; Reaction=H(+) + NADPH + O2 + sulcatone = 4-methylpent-3-en-1-yl acetate + H2O + NADP(+); Xref=Rhea:RHEA:54864, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16310, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:138373; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54865; Evidence=; Reaction=H(+) + NADPH + O2 = H2O2 + NADP(+); Xref=Rhea:RHEA:11260, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.6.3.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11261; Evidence=; Reaction=H(+) + heptan-2-one + NADPH + O2 = H2O + NADP(+) + pentyl acetate; Xref=Rhea:RHEA:54836, ChEBI:CHEBI:5672, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:87362; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54837; Evidence=; Reaction=H(+) + heptan-4-one + NADPH + O2 = H2O + NADP(+) + propyl butanoate; Xref=Rhea:RHEA:54852, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:89484, ChEBI:CHEBI:89719; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54853; Evidence=; Reaction=H(+) + hexan-3-one + NADPH + O2 = H2O + NADP(+) + propyl propanoate; Xref=Rhea:RHEA:54848, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:89828, ChEBI:CHEBI:89891; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54849; Evidence=; Reaction=H(+) + hexan-3-one + NADPH + O2 = ethyl butanoate + H2O + NADP(+); Xref=Rhea:RHEA:54844, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88764, ChEBI:CHEBI:89891; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54845; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Endoplasmic reticulum membrane Membrane Microsome membrane Belongs to the FMO family. monooxygenase activity N,N-dimethylaniline monooxygenase activity cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane oxidoreductase activity organelle membrane intracellular membrane-bounded organelle flavin adenine dinucleotide binding NADP binding oxidation-reduction process uc007dkq.1 uc007dkq.2 
ENSMUST00000027846.8 Tada1 ENSMUST00000027846.8 transcriptional adaptor 1 (from RefSeq NM_030245.3) ENSMUST00000027846.1 ENSMUST00000027846.2 ENSMUST00000027846.3 ENSMUST00000027846.4 ENSMUST00000027846.5 ENSMUST00000027846.6 ENSMUST00000027846.7 NM_030245 Q99LM9 TADA1_MOUSE Tada1l uc007dkm.1 uc007dkm.2 uc007dkm.3 uc007dkm.4 uc007dkm.5 Probably involved in transcriptional regulation. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Nucleus Belongs to the TADA1 family. SAGA complex transcription coactivator activity histone acetyltransferase activity nucleus nucleoplasm cytosol focal adhesion regulation of transcription from RNA polymerase II promoter STAGA complex histone H3 acetylation SAGA-type complex positive regulation of nucleic acid-templated transcription uc007dkm.1 uc007dkm.2 uc007dkm.3 uc007dkm.4 uc007dkm.5 
ENSMUST00000027853.6 Mpc2 ENSMUST00000027853.6 mitochondrial pyruvate carrier 2 (from RefSeq NM_027430.3) Brp44 ENSMUST00000027853.1 ENSMUST00000027853.2 ENSMUST00000027853.3 ENSMUST00000027853.4 ENSMUST00000027853.5 MPC2_MOUSE NM_027430 Q3UA44 Q9D023 uc007djd.1 uc007djd.2 uc007djd.3 Mediates the uptake of pyruvate into mitochondria. Reaction=H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in); Xref=Rhea:RHEA:64720, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378; Evidence=; Homodimer. Homooligomer. Forms heterodimers with MPC1 and MPC1L. The heterodimer is the more stable and dominant form. Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. mitochondrion mitochondrial inner membrane mitochondrial pyruvate transport membrane integral component of membrane integral component of mitochondrial inner membrane positive regulation of insulin secretion involved in cellular response to glucose stimulus pyruvate transmembrane transporter activity mitochondrial acetyl-CoA biosynthetic process from pyruvate uc007djd.1 uc007djd.2 uc007djd.3 
ENSMUST00000027856.13 Dcaf6 ENSMUST00000027856.13 DDB1 and CUL4 associated factor 6 (from RefSeq NM_028759.1) DCAF6_MOUSE ENSMUST00000027856.1 ENSMUST00000027856.10 ENSMUST00000027856.11 ENSMUST00000027856.12 ENSMUST00000027856.2 ENSMUST00000027856.3 ENSMUST00000027856.4 ENSMUST00000027856.5 ENSMUST00000027856.6 ENSMUST00000027856.7 ENSMUST00000027856.8 ENSMUST00000027856.9 Iqwd1 NM_028759 Q8BK50 Q9DC22 uc007djb.1 uc007djb.2 uc007djb.3 uc007djb.4 uc007djb.5 Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). Protein modification; protein ubiquitination. Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand. Interacts with DDB1, CUL4A and CUL4B (By similarity). Nucleus nucleus cytosol focal adhesion protein ubiquitination ligand-dependent nuclear receptor transcription coactivator activity positive regulation of transcription from RNA polymerase II promoter Cul4-RING E3 ubiquitin ligase complex uc007djb.1 uc007djb.2 uc007djb.3 uc007djb.4 uc007djb.5 
ENSMUST00000027859.12 Tbx19 ENSMUST00000027859.12 T-box 19 (from RefSeq NM_032005.4) ENSMUST00000027859.1 ENSMUST00000027859.10 ENSMUST00000027859.11 ENSMUST00000027859.2 ENSMUST00000027859.3 ENSMUST00000027859.4 ENSMUST00000027859.5 ENSMUST00000027859.6 ENSMUST00000027859.7 ENSMUST00000027859.8 ENSMUST00000027859.9 NM_032005 Q0VBH2 Q99ME7 TBX19_MOUSE Tbx19 Tpit uc007diw.1 uc007diw.2 uc007diw.3 This gene encodes a member of a family of transcription factors containing a characteristic T-box DNA-binding domain. The encoded protein promotes expression of the pro-opiomelanocortin (POMC) gene, which is important for the differentiation of cells in the pituitary gland. [provided by RefSeq, Mar 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK038666.1, BC120635.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849377 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters. Nucleus negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II activating transcription factor binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding mesoderm formation cell fate specification somitogenesis heart morphogenesis DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated pituitary gland development regulation of cell proliferation cell fate commitment regulation of cell differentiation positive regulation of transcription from RNA polymerase II promoter uc007diw.1 uc007diw.2 uc007diw.3 
ENSMUST00000027860.8 Xcl1 ENSMUST00000027860.8 chemokine (C motif) ligand 1 (from RefSeq NM_008510.3) ENSMUST00000027860.1 ENSMUST00000027860.2 ENSMUST00000027860.3 ENSMUST00000027860.4 ENSMUST00000027860.5 ENSMUST00000027860.6 ENSMUST00000027860.7 NM_008510 Q542T1 Q542T1_MOUSE XCL1 Xcl1 uc007dis.1 uc007dis.2 uc007dis.3 Secreted Belongs to the intercrine gamma family. extracellular region immune response chemokine activity cell chemotaxis uc007dis.1 uc007dis.2 uc007dis.3 
ENSMUST00000027861.6 Dpt ENSMUST00000027861.6 dermatopontin (from RefSeq NM_019759.3) DERM_MOUSE ENSMUST00000027861.1 ENSMUST00000027861.2 ENSMUST00000027861.3 ENSMUST00000027861.4 ENSMUST00000027861.5 NM_019759 Q9D2B6 Q9QZZ6 uc007diq.1 uc007diq.2 uc007diq.3 Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity (By similarity). Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low- temperature dissociation. Interacts with TGFB1, DCN and collagen. Secreted, extracellular space, extracellular matrix Induced by cell quiescence. Sulfated on tyrosine residue(s). Mice have reduced skin elasticity, a decrease in skin-thickness, and lower collagen content in the skin. Belongs to the dermatopontin family. extracellular matrix structural constituent extracellular region extracellular space cell adhesion negative regulation of cell proliferation collagen fibril organization uc007diq.1 uc007diq.2 uc007diq.3 
ENSMUST00000027863.13 Atp1b1 ENSMUST00000027863.13 ATPase, Na+/K+ transporting, beta 1 polypeptide (from RefSeq NM_009721.6) Atp1b1 ENSMUST00000027863.1 ENSMUST00000027863.10 ENSMUST00000027863.11 ENSMUST00000027863.12 ENSMUST00000027863.2 ENSMUST00000027863.3 ENSMUST00000027863.4 ENSMUST00000027863.5 ENSMUST00000027863.6 ENSMUST00000027863.7 ENSMUST00000027863.8 ENSMUST00000027863.9 NM_009721 Q545P0 Q545P0_MOUSE uc007dip.1 uc007dip.2 uc007dip.3 uc007dip.4 This gene encodes an integral membrane protein that comprises a subunit of an ATP-metabolizing enzyme responsible for transporting sodium and potassium ions across the plasma membrane. This enzyme regulates the electrochemical gradient of these ions in cells, and plays a central role in osmoregulation and signal transmission in nerves and muscles, among other biological processes. The encoded protein is the non-catalytic beta subunit; it works together with a catalytic alpha subunit and a gamma subunit. [provided by RefSeq, Mar 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK160405.1, AK010677.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849378, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Involved in cell adhesion and establishing epithelial cell polarity. This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Apical cell membrane ; Single-pass type II membrane protein Cell membrane, sarcolemma Cell membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the X(+)/potassium ATPases subunit beta family. response to hypoxia ATPase activator activity sodium:potassium-exchanging ATPase activity ATP binding plasma membrane sodium:potassium-exchanging ATPase complex caveola ion transport potassium ion transport sodium ion transport cellular sodium ion homeostasis drug binding establishment or maintenance of transmembrane electrochemical gradient membrane integral component of membrane basolateral plasma membrane apical plasma membrane ATPase activity metal ion transport cellular potassium ion homeostasis potassium ion binding sodium ion binding positive regulation of ATPase activity sodium ion export from cell ATP metabolic process protein stabilization ATPase binding protein localization to plasma membrane membrane repolarization positive regulation of potassium ion transmembrane transporter activity positive regulation of sodium ion export from cell positive regulation of potassium ion import potassium ion import across plasma membrane uc007dip.1 uc007dip.2 uc007dip.3 uc007dip.4 
ENSMUST00000027867.7 Ccdc181 ENSMUST00000027867.7 coiled-coil domain containing 181 (from RefSeq NM_029115.3) CC181_MOUSE Ccdc181 ENSMUST00000027867.1 ENSMUST00000027867.2 ENSMUST00000027867.3 ENSMUST00000027867.4 ENSMUST00000027867.5 ENSMUST00000027867.6 NM_029115 Q3UF07 Q80ZU5 Q8C631 Q9CUL9 uc007dif.1 uc007dif.2 uc007dif.3 uc007dif.4 Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Homodimer (PubMed:28283191). Interacts with HOOK1 (PubMed:28283191). Interacts with HOOK2 (PubMed:28283191). Interacts with HOOK3 (PubMed:28283191). Cytoplasm, cytoskeleton Cell projection, cilium, flagellum Note=Localizes to the microtubular manchette of elongating spermatids (PubMed:28283191). Localizes to the sperm flagella and to the basal half of motile cilia (PubMed:28283191). Predominantly expressed in testis (PubMed:28283191). Expressed at lower level in brain, eye, trachea and lung (PubMed:28283191). Barely expressed in tongue, heart, liver, kidney, spleen and muscle (PubMed:28283191). Present at high level in elongating spermatids, whereas lower levels are observed in round spermatids (at protein level) (PubMed:28283191). In testis, expressed at low level until day 20, when round spermatids appear for the first time. After day 20, a sharp and constant increase of expression is observed. Belongs to the CCDC181 family. manchette protein binding cytoplasm cytoskeleton microtubule cilium microtubule binding biological_process motile cilium sperm flagellum cell projection uc007dif.1 uc007dif.2 uc007dif.3 uc007dif.4 
ENSMUST00000027871.13 Sell ENSMUST00000027871.13 selectin, lymphocyte, transcript variant 1 (from RefSeq NM_011346.2) ENSMUST00000027871.1 ENSMUST00000027871.10 ENSMUST00000027871.11 ENSMUST00000027871.12 ENSMUST00000027871.2 ENSMUST00000027871.3 ENSMUST00000027871.4 ENSMUST00000027871.5 ENSMUST00000027871.6 ENSMUST00000027871.7 ENSMUST00000027871.8 ENSMUST00000027871.9 NM_011346 Q3UV83 Q3UV83_MOUSE Sell uc007dhy.1 uc007dhy.2 uc007dhy.3 uc007dhy.4 Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the selectin/LECAM family. Lacks conserved residue(s) required for the propagation of feature annotation. cell adhesion membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules carbohydrate binding metal ion binding leukocyte migration uc007dhy.1 uc007dhy.2 uc007dhy.3 uc007dhy.4 
ENSMUST00000027874.7 Sele ENSMUST00000027874.7 selectin, endothelial cell (from RefSeq NM_011345.3) ENSMUST00000027874.1 ENSMUST00000027874.2 ENSMUST00000027874.3 ENSMUST00000027874.4 ENSMUST00000027874.5 ENSMUST00000027874.6 NM_011345 Q3U5F6 Q3U5F6_MOUSE Sele uc007dhx.1 uc007dhx.2 uc007dhx.3 Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the selectin/LECAM family. Lacks conserved residue(s) required for the propagation of feature annotation. positive regulation of receptor internalization transmembrane signaling receptor activity calcium ion binding extracellular space integral component of plasma membrane caveola clathrin-coated pit cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion activation of phospholipase C activity membrane integral component of membrane actin filament-based process carbohydrate binding cortical cytoskeleton sialic acid binding phospholipase binding membrane raft perinuclear region of cytoplasm leukocyte tethering or rolling oligosaccharide binding response to interleukin-1 uc007dhx.1 uc007dhx.2 uc007dhx.3 
ENSMUST00000027876.11 Scyl3 ENSMUST00000027876.11 SCY1-like 3 (S. cerevisiae), transcript variant 1 (from RefSeq NM_028776.5) ENSMUST00000027876.1 ENSMUST00000027876.10 ENSMUST00000027876.2 ENSMUST00000027876.3 ENSMUST00000027876.4 ENSMUST00000027876.5 ENSMUST00000027876.6 ENSMUST00000027876.7 ENSMUST00000027876.8 ENSMUST00000027876.9 NM_028776 PACE1_MOUSE Pace1 Q3TRA7 Q6NY01 Q8BQC9 Q8BRJ1 Q9DBQ7 uc007dhq.1 uc007dhq.2 uc007dhq.3 May play a role in regulating cell adhesion/migration complexes in migrating cells. Interacts with EZR/VIL2 C-terminal domain. Cytoplasm Golgi apparatus Cell projection, lamellipodium Note=Colocalized with EZR/VIL2, actin and CD44 in lamellipodia. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DBQ7-1; Sequence=Displayed; Name=2; IsoId=Q9DBQ7-2; Sequence=VSP_037985, VSP_013126; Name=3; IsoId=Q9DBQ7-3; Sequence=VSP_027369; The protein kinase domain is predicted to be catalytically inactive. May be myristoylated; myristoylation may target it to Golgi compartment. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the protein kinase superfamily. Sequence=BAC31777.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; Sequence=BC066800; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; protein kinase activity ATP binding cytoplasm Golgi apparatus protein phosphorylation biological_process lamellipodium cell projection uc007dhq.1 uc007dhq.2 uc007dhq.3 
ENSMUST00000027877.7 Kifap3 ENSMUST00000027877.7 kinesin-associated protein 3, transcript variant 1 (from RefSeq NM_001305643.1) ENSMUST00000027877.1 ENSMUST00000027877.2 ENSMUST00000027877.3 ENSMUST00000027877.4 ENSMUST00000027877.5 ENSMUST00000027877.6 KIFA3_MOUSE NM_001305643 P70188 P70189 Q6GTS3 uc007dhp.1 uc007dhp.2 uc007dhp.3 uc007dhp.4 The protein encoded by this gene is the non-motor subunit of kinesin-2 complex, and forms a heterotrimer with two members of the kinesin superfamily of proteins that together form a microtubule plus-end directed translocator that plays an important role in intracellular transport, mitosis, and cell-cell adhesion. This protein contains multiple armadillo repeats involved in protein binding, and may serve as an adaptor to regulate binding of cargo with the motor proteins. Conditional disruption of this gene in mouse neural precursor cells caused a tumor-like phenotype and defective organization of the neuroepithelium thought to be the result of altered N-cadherin subcellular localization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]. Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex. Interacts with SMC3 subunit of the cohesin complex (By similarity). Heterotrimer of KIFAP3, KIF3A and KIF3B. Interacts with RAP1GDS1/SMG GDS. P70188; P28741: Kif3a; NbExp=4; IntAct=EBI-6169443, EBI-6169413; Event=Alternative splicing; Named isoforms=2; Name=KAP3A; IsoId=P70188-1; Sequence=Displayed; Name=KAP3B; IsoId=P70188-2; Sequence=VSP_003899; Phosphorylated on tyrosine residues by SRC in vitro; this reduces the binding affinity of the protein for RAP1GDS1. condensed nuclear chromosome protein binding endoplasmic reticulum Golgi apparatus centrosome cytosol kinesin complex spindle microtubule axoneme microtubule-based process protein localization negative regulation of cell proliferation microtubule cytoskeleton kinesin II complex kinesin binding protein phosphatase binding photoreceptor connecting cilium ciliary basal body negative regulation of apoptotic process positive regulation of calcium-dependent cell-cell adhesion periciliary membrane compartment uc007dhp.1 uc007dhp.2 uc007dhp.3 uc007dhp.4 
ENSMUST00000027878.14 Prrx1 ENSMUST00000027878.14 paired related homeobox 1, transcript variant 1 (from RefSeq NM_011127.2) ENSMUST00000027878.1 ENSMUST00000027878.10 ENSMUST00000027878.11 ENSMUST00000027878.12 ENSMUST00000027878.13 ENSMUST00000027878.2 ENSMUST00000027878.3 ENSMUST00000027878.4 ENSMUST00000027878.5 ENSMUST00000027878.6 ENSMUST00000027878.7 ENSMUST00000027878.8 ENSMUST00000027878.9 NM_011127 P43271 P63013 PRRX1_MOUSE Pmx Pmx1 Q02810 Q569N6 uc007dhi.1 uc007dhi.2 uc007dhi.3 Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process (PubMed:35589735). Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (PubMed:1360403). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (PubMed:36456880). [Isoform 1]: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. [Isoform 2]: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines. Interacts with SMAD3. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=K2-a, Prx1a ; IsoId=P63013-1, P43271-1; Sequence=Displayed; Name=2; Synonyms=K2-b, Prx1b ; IsoId=P63013-2, P43271-2; Sequence=VSP_002279; Expressed in skeletal muscle, heart and uterus (PubMed:1360403). Detected in a limited numbers of cells in connective tissues, in bone, inguinal white adipose tissue and dermis; these cells are thought to be stem cells (PubMed:36456880). First expressed at 8.5 dpc in the paraxial and intermediate mesoderm besides the lateral plate mesoderm (PubMed:36456880). At about 9 dpc, detected in the lateral mesoderm and newly formed visceral arches (PubMed:1360403). At 9.5 dpc, expressed in multiple mesoderm segments (PubMed:36456880). Strongly expressed in the visceral arches, newly formed limb buds and facial primordia. Expression in the somites is confined primarily to the dorsal dermamyotome. Also detected in the dorsal aorta. At 10.5 dpc, strong expression is maintained in the visceral arches and facial primordia, as well as in the developing limb buds and dorsal aorta. At 13.5 dpc, highest expression in the limb buds, but not in the central core of the limb, which corresponds to regions of cartilage differentiation. Lower levels in the condensing vertebrae and ribs of the axial skeleton. Detected in the mandibles, which are derived from the visceral arches. Moderate expression levels in intercostal muscles and diaphragm. Also expressed in the developing eye and the meninges of the brain, but not in the brain itself. Not detected in the developing internal organs, such as heart, liver and gut (PubMed:1360403). At 14.5 dpc, expressed in skeletal tissues and the dermis (PubMed:36456880). At 15.5 dpc, moderate expression levels in the perichondrial tissue surrounding the ribs, the intercostal muscles and the diaphragm. Strongly expressed in the distal tips of the phalanges of the digits as well as in the perichondrial tissue surrounding the developing skeleton. At this stage, expression is generally low in the embryo and is only detectable in the face, limbs and axial muscles. Expression in the neural tube (brain and spinal cord) is not be detected at any developmental stage (PubMed:1360403). At postnatal day 1, detected in the skeleton, white adipose tissue and the dermis (PubMed:36456880). [Isoform 1]: The C-terminal OAR domain may be masking the transactivation domains. [Isoform 2]: The C-terminal domain encoded by the alternative exon 4 exhibits repressor activity. Belongs to the paired homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding positive regulation of mesenchymal cell proliferation DNA binding transcription coactivator activity nucleus nucleoplasm cytosol regulation of transcription, DNA-templated multicellular organism development embryonic limb morphogenesis inner ear morphogenesis middle ear morphogenesis sequence-specific DNA binding positive regulation of smoothened signaling pathway positive regulation of transcription from RNA polymerase II promoter neuron fate determination embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis artery morphogenesis cartilage development palate development regulation of neuron projection regeneration HMG box domain binding neuronal stem cell population maintenance uc007dhi.1 uc007dhi.2 uc007dhi.3 
ENSMUST00000027885.8 Angptl1 ENSMUST00000027885.8 angiopoietin-like 1 (from RefSeq NM_028333.3) ANGL1_MOUSE ENSMUST00000027885.1 ENSMUST00000027885.2 ENSMUST00000027885.3 ENSMUST00000027885.4 ENSMUST00000027885.5 ENSMUST00000027885.6 ENSMUST00000027885.7 NM_028333 Q3UQL1 Q640P2 Q9CZ81 uc007ddd.1 uc007ddd.2 uc007ddd.3 uc007ddd.4 uc007ddd.5 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q640P2-1; Sequence=Displayed; Name=2; IsoId=Q640P2-2; Sequence=VSP_013722, VSP_013723; Sequence=BAB28537.1; Type=Frameshift; Evidence=; receptor binding extracellular region extracellular space transmembrane receptor protein tyrosine kinase signaling pathway uc007ddd.1 uc007ddd.2 uc007ddd.3 uc007ddd.4 uc007ddd.5 
ENSMUST00000027888.13 Abl2 ENSMUST00000027888.13 ABL proto-oncogene 2, non-receptor tyrosine kinase, transcript variant 2 (from RefSeq NM_009595.3) Abl2 ENSMUST00000027888.1 ENSMUST00000027888.10 ENSMUST00000027888.11 ENSMUST00000027888.12 ENSMUST00000027888.2 ENSMUST00000027888.3 ENSMUST00000027888.4 ENSMUST00000027888.5 ENSMUST00000027888.6 ENSMUST00000027888.7 ENSMUST00000027888.8 ENSMUST00000027888.9 F8VQH0 F8VQH0_MOUSE NM_009595 uc007dcl.1 uc007dcl.2 uc007dcl.3 uc007dcl.4 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Belongs to the protein kinase superfamily. Tyr protein kinase family. nucleotide binding magnesium ion binding phosphotyrosine binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity ATP binding cell protein phosphorylation positive regulation of cytosolic calcium ion concentration positive regulation of phospholipase C activity positive regulation of neuron projection development kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation manganese ion binding positive regulation of oxidoreductase activity cellular response to retinoic acid uc007dcl.1 uc007dcl.2 uc007dcl.3 uc007dcl.4 
ENSMUST00000027896.10 Nphs2 ENSMUST00000027896.10 nephrosis 2, podocin (from RefSeq NM_130456.4) ENSMUST00000027896.1 ENSMUST00000027896.2 ENSMUST00000027896.3 ENSMUST00000027896.4 ENSMUST00000027896.5 ENSMUST00000027896.6 ENSMUST00000027896.7 ENSMUST00000027896.8 ENSMUST00000027896.9 NM_130456 PODO_MOUSE Q8BWE6 Q91X05 Q91Z95 uc007dch.1 uc007dch.2 uc007dch.3 uc007dch.4 Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. Interacts with nephrin/NPHS1, KIRRL1 and CD2AP. Interacts with DDN. Membrane ; Single-pass membrane protein Belongs to the band 7/mec-2 family. protein binding plasma membrane cell-cell junction membrane integral component of membrane intrinsic component of the cytoplasmic side of the plasma membrane actin cytoskeleton reorganization macromolecular complex slit diaphragm membrane raft metanephric glomerular visceral epithelial cell development uc007dch.1 uc007dch.2 uc007dch.3 uc007dch.4 
ENSMUST00000027897.8 Smyd2 ENSMUST00000027897.8 SET and MYND domain containing 2 (from RefSeq NM_026796.2) ENSMUST00000027897.1 ENSMUST00000027897.2 ENSMUST00000027897.3 ENSMUST00000027897.4 ENSMUST00000027897.5 ENSMUST00000027897.6 ENSMUST00000027897.7 NM_026796 Q3UBQ2 Q8R5A0 SMYD2_MOUSE uc007eax.1 uc007eax.2 uc007eax.3 Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. Reaction=L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60260, Rhea:RHEA-COMP:15537, Rhea:RHEA- COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.354; Evidence=; Reaction=L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:51736, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13053, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence=; Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1 (By similarity). Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1. Q8R5A0; P04637: TP53; Xeno; NbExp=3; IntAct=EBI-15612527, EBI-366083; Cytoplasm, cytosol. Nucleus. Highly expressed in heart, skeletal muscle and brain tissue. During cardiac development, it is differentially expressed with highest expression in the neonatal heart while very low expression is detected at 12.5 dpc and adult. Specifically expressed in cardiomyocytes (at protein level). Although specifically expressed in cardiomyocytes, a conditional deletion in heart does not lead to any visible phenotype. Belongs to the class V-like SAM-binding methyltransferase superfamily. The protein was previously thought to dimethylate histone 3 'Lys-36', but this is now known not to take place in vivo. Sequence=BAE29912.1; Type=Miscellaneous discrepancy; Note=Deletion within an exon that does not correspond to an intron.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core binding p53 binding protein binding nucleus cytoplasm cytosol chromatin organization heart development methyltransferase activity negative regulation of cell proliferation histone H3-K36 methylation protein-lysine N-methyltransferase activity histone methylation transferase activity histone-lysine N-methyltransferase activity peptidyl-lysine monomethylation peptidyl-lysine dimethylation methylation histone lysine methylation regulation of DNA damage response, signal transduction by p53 class mediator metal ion binding histone methyltransferase activity (H3-K36 specific) uc007eax.1 uc007eax.2 uc007eax.3 
ENSMUST00000027906.13 Esrrg ENSMUST00000027906.13 estrogen-related receptor gamma, transcript variant 1 (from RefSeq NM_011935.3) ENSMUST00000027906.1 ENSMUST00000027906.10 ENSMUST00000027906.11 ENSMUST00000027906.12 ENSMUST00000027906.2 ENSMUST00000027906.3 ENSMUST00000027906.4 ENSMUST00000027906.5 ENSMUST00000027906.6 ENSMUST00000027906.7 ENSMUST00000027906.8 ENSMUST00000027906.9 ERR3_MOUSE Err3 Kiaa0832 NM_011935 Nr3b3 O75454 O96021 P62509 Q8CHC9 Q9R1F3 uc007eab.1 uc007eab.2 uc007eab.3 uc007eab.4 Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle. Homodimer. Interacts with NRIP1, NCOA1 and NCOR2 (By similarity). Binds TLE1, PNRC1 and PNRC2 (By similarity). Binds GRIP1. P62509; Q91ZR3: Crebzf; NbExp=3; IntAct=EBI-5274019, EBI-5274001; P62509; Q9NS37: CREBZF; Xeno; NbExp=3; IntAct=EBI-5274019, EBI-632965; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=P62509-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P62509-2; Sequence=VSP_010766; Highly expressed in the heart, brain and kidney and low expression in the liver. Acetylated by PCAF/KAT2 (in vitro). Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity. Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity. Cardiomyocyte-specific double konckout for ESRRA and ESRRG are slower at gaining weight, smaller and shorter from 5 to 7 days of age compared to controls. They show decreased absolute weight of most internal organs except the heart. They have about 70% decreased plasma IGF1 levels but normal plasma growth hormone levels. At 14-15 days, mutants develop lethal dilated cardiomyopathy and heart failure. No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG. Belongs to the nuclear hormone receptor family. NR3 subfamily. Sequence=BAC41450.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding steroid binding protein binding calmodulin binding nucleus regulation of transcription, DNA-templated multicellular organism development zinc ion binding steroid hormone mediated signaling pathway sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding retinoic acid receptor signaling pathway uc007eab.1 uc007eab.2 uc007eab.3 uc007eab.4 
ENSMUST00000027916.13 Bpnt1 ENSMUST00000027916.13 3'(2'), 5'-bisphosphate nucleotidase 1, transcript variant 1 (from RefSeq NM_011794.3) BPNT1_MOUSE ENSMUST00000027916.1 ENSMUST00000027916.10 ENSMUST00000027916.11 ENSMUST00000027916.12 ENSMUST00000027916.2 ENSMUST00000027916.3 ENSMUST00000027916.4 ENSMUST00000027916.5 ENSMUST00000027916.6 ENSMUST00000027916.7 ENSMUST00000027916.8 ENSMUST00000027916.9 NM_011794 Q3U8Z5 Q91XB9 Q9D7Y0 Q9Z0S1 uc007dzc.1 uc007dzc.2 uc007dzc.3 Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6. Reaction=adenosine 3',5'-bisphosphate + H2O = AMP + phosphate; Xref=Rhea:RHEA:10040, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58343, ChEBI:CHEBI:456215; EC=3.1.3.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10041; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Uncompetitive inhibition by micromolar concentrations of lithium. Competitive inhibition by inositol 1,4- bisphosphate. Kinetic parameters: KM=520 nM for adenosine 3',5'-bisphosphate (PAP) ; Vmax=42 umol/min/mg enzyme with adenosine 3',5'-bisphosphate (PAP) as substrate ; pH dependence: Optimum pH is approximately 7.5. ; Widely expressed. Highly expressed in kidney. Belongs to the inositol monophosphatase superfamily. magnesium ion binding inositol-1,4-bisphosphate 1-phosphatase activity 3'(2'),5'-bisphosphate nucleotidase activity dephosphorylation hydrolase activity phosphatidylinositol phosphorylation metal ion binding uc007dzc.1 uc007dzc.2 uc007dzc.3 
ENSMUST00000027921.11 Iars2 ENSMUST00000027921.11 isoleucine-tRNA synthetase 2, mitochondrial (from RefSeq NM_198653.3) ENSMUST00000027921.1 ENSMUST00000027921.10 ENSMUST00000027921.2 ENSMUST00000027921.3 ENSMUST00000027921.4 ENSMUST00000027921.5 ENSMUST00000027921.6 ENSMUST00000027921.7 ENSMUST00000027921.8 ENSMUST00000027921.9 Iars2 NM_198653 Q3TKT8 Q8BIJ0 Q8BIJ6 Q8BIP3 SYIM_MOUSE uc007dyz.1 uc007dyz.2 uc007dyz.3 Aminoacyl-tRNA synthetase that catalyzes the specific attachment of isoleucine to its cognate tRNA (tRNA(Ile)). Reaction=ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L- isoleucyl-tRNA(Ile); Xref=Rhea:RHEA:11060, Rhea:RHEA-COMP:9666, Rhea:RHEA-COMP:9695, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58045, ChEBI:CHEBI:78442, ChEBI:CHEBI:78528, ChEBI:CHEBI:456215; EC=6.1.1.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11061; Evidence=; Mitochondrion matrix Belongs to the class-I aminoacyl-tRNA synthetase family. tRNA binding nucleotide binding aminoacyl-tRNA editing activity aminoacyl-tRNA ligase activity isoleucine-tRNA ligase activity ATP binding mitochondrion mitochondrial matrix cytosol translation tRNA aminoacylation for protein translation isoleucyl-tRNA aminoacylation ligase activity mitochondrial translation uc007dyz.1 uc007dyz.2 uc007dyz.3 
ENSMUST00000027929.10 Mark1 ENSMUST00000027929.10 MAP/microtubule affinity regulating kinase 1, transcript variant 2 (from RefSeq NM_145515.2) E9QL17 ENSMUST00000027929.1 ENSMUST00000027929.2 ENSMUST00000027929.3 ENSMUST00000027929.4 ENSMUST00000027929.5 ENSMUST00000027929.6 ENSMUST00000027929.7 ENSMUST00000027929.8 ENSMUST00000027929.9 Emk3 Kiaa1477 MARK1_MOUSE Mark1 NM_145515 Q69ZI7 Q8VHJ5 uc007dyt.1 uc007dyt.2 uc007dyt.3 uc007dyt.4 Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl- [tau protein]; Xref=Rhea:RHEA:12801, Rhea:RHEA-COMP:13701, Rhea:RHEA- COMP:13702, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.26; Reaction=ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L- threonyl-[tau protein]; Xref=Rhea:RHEA:53904, Rhea:RHEA-COMP:13703, Rhea:RHEA-COMP:13704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.26; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by phosphorylation at Ser-219. Activated by phosphorylation on Thr-215 (By similarity). Interacts with MAPT/TAU. Cell membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton Cytoplasm Cell projection, dendrite Note=Appears to localize to an intracellular network. The UBA domain does not seem to bind ubiquitin and ubiquitin- like and might play a role in regulating the enzyme conformation and localization. Activation of the kinase activity following phosphorylation at Thr-208 is accompanied by a conformational change that alters the orientation of the UBA domain with respect to the catalytic domain (By similarity). The KA1 domain mediates binding to phospholipids and targeting to membranes. Binds phosphatidic acid (PA), phosphatidylserine (PtdSer) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (By similarity). Phosphorylated at Thr-215 by STK11/LKB1 in complex with STE20- related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-215 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-219 by GSK3-beta (GSK3B) inhibits the kinase activity. Phosphorylation at Thr-613 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. nucleotide binding microtubule cytoskeleton organization magnesium ion binding neuron migration phosphatidylserine binding protein kinase activity protein serine/threonine kinase activity ATP binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm cytoskeleton plasma membrane protein phosphorylation cytoskeleton organization lipid binding regulation of neuron projection development membrane Wnt signaling pathway kinase activity phosphorylation transferase activity dendrite intracellular signal transduction cell projection metal ion binding tau-protein kinase activity regulation of dendrite development establishment of mitochondrion localization phosphatidic acid binding uc007dyt.1 uc007dyt.2 uc007dyt.3 uc007dyt.4 
ENSMUST00000027931.8 Nek2 ENSMUST00000027931.8 NIMA (never in mitosis gene a)-related expressed kinase 2, transcript variant 1 (from RefSeq NM_010892.4) ENSMUST00000027931.1 ENSMUST00000027931.2 ENSMUST00000027931.3 ENSMUST00000027931.4 ENSMUST00000027931.5 ENSMUST00000027931.6 ENSMUST00000027931.7 NEK2_MOUSE NM_010892 O35942 O35959 Q3TPD7 uc007ecx.1 uc007ecx.2 uc007ecx.3 uc007ecx.4 Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (By similarity). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (By similarity). Phosphorylates and activates NEK11 in G1/S-arrested cells. Involved in the regulation of centrosome disjunction (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Its catalytic activity is inhibited by the inhibitor CCT241950. In the presence of this inhibitor, displays an autoinhibited conformation: Tyr-70 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix. Forms homodimers and heterodimers. Interacts with CDC20, CTNB1, MAD1L1, MAD2L1, MAPK, NEK11, NPM1, NDC80, PCNT, PPP1CA, PPP1CC and SGO1. Interacts with STK3/MST2 (via SARAH domain) and SAV1 (via SARAH domain) (By similarity). Interacts with NECAB3 and HMGA2 (PubMed:14697346, PubMed:14668482). Interacts with CEP68; the interaction leads to phosphorylation of CEP68. Interacts with CNTLN; the interaction leads to phosphorylation of CNTLN. Interacts with CEP85 (By similarity). Nucleus Nucleus, nucleolus Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Chromosome, centromere, kinetochore Chromosome, centromere Note=STK3/MST2 and SAV1 are required for its targeting to the centrosome. Colocalizes with SGO1 and MAD1L1 at the kinetochore. Not associated with kinetochore in the interphase but becomes associated with it upon the breakdown of the nuclear envelope. Has a nucleolar targeting/ retention activity via a coiled-coil domain at the C-terminal end (By similarity). Most abundantly expressed in testis. Low levels found in mid-gestation embryo, ovary, placenta, intestine, thymus and skin. Within the testis, expression restricted to germ cells with highest levels detected in spermatocytes at pachytene and diplotene stages. Also expressed in meiotic pachytene oocytes. The leucine-zipper domain is required for its dimerization and activation. Activated by autophosphorylation. Protein phosphatase 1 represses autophosphorylation and activation of isoform 1 by dephosphorylation. Phosphorylation by STK3/MST2 is necessary for its localization to the centrosome. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. mitotic sister chromatid segregation nucleotide binding chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed nuclear chromosome spindle pole blastocyst development protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm chromosome nucleolus cytoplasm centrosome microtubule organizing center cytoskeleton microtubule protein phosphorylation cell cycle chromosome segregation kinase activity phosphorylation transferase activity protein phosphatase binding midbody positive regulation of telomere maintenance via telomerase macromolecular complex negative regulation of DNA binding regulation of mitotic centrosome separation protein autophosphorylation metal ion binding centrosome separation cell division meiotic cell cycle positive regulation of telomerase activity regulation of attachment of spindle microtubules to kinetochore mitotic spindle assembly negative regulation of centriole-centriole cohesion positive regulation of telomere capping uc007ecx.1 uc007ecx.2 uc007ecx.3 uc007ecx.4 
ENSMUST00000027933.11 Dtl ENSMUST00000027933.11 denticleless E3 ubiquitin protein ligase, transcript variant 1 (from RefSeq NM_029766.3) Cdt2 DTL_MOUSE ENSMUST00000027933.1 ENSMUST00000027933.10 ENSMUST00000027933.2 ENSMUST00000027933.3 ENSMUST00000027933.4 ENSMUST00000027933.5 ENSMUST00000027933.6 ENSMUST00000027933.7 ENSMUST00000027933.8 ENSMUST00000027933.9 L2dtl NM_029766 Q3TLR7 Q3TTE9 Q6PAN1 Q80WY1 Q80WY2 Q8BW38 Q9CZ76 Ramp uc007eck.1 uc007eck.2 uc007eck.3 uc007eck.4 Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. The DDB1- CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (By similarity). Protein modification; protein ubiquitination. Component of the DCX(DTL) E3 ubiquitin ligase complex (also called CRL4(CDT2)), at least composed of CUL4 (CUL4A or CUL4B), DDB1, DTL/CDT2 and RBX1 (By similarity). Interacts with CDKN1A and DDB1 (By similarity). Interacts with FBXO11; SCF(FBXWO11) controls DTL stability but DCX(DTL) does not control FBXO11 stability (By similarity). Interacts with CRY1 (By similarity). Nucleus Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Chromosome Note=Nuclear matrix- associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TLR7-1; Sequence=Displayed; Name=2; IsoId=Q3TLR7-2; Sequence=VSP_022886; Name=3; IsoId=Q3TLR7-4; Sequence=VSP_022884, VSP_022885; Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C). Autoubiquitinated through 'Lys-48'-polyubiquitin chains in a PCNA- independent reaction, allowing proteasomal turnover. Polyubiquitinated by SCF(FBXO11) when not phosphorylated, leading to its degradation. A tight regulation of the polyubiquitination by SCF(FBXO11) is involved in the control of different processes such as TGF-beta signaling, cell cycle progression and exit (By similarity). Phosphorylated at Thr-463 by CDK1/Cyclin B and CDK2/Cycnlin A but not by CDK2/Cyclin E, MAPK1 or PLK1. Phosphorylation at Thr-463 inhibits the interaction with FBXO11 and decreases upon cell cycle exit induced by TGF-beta or serum starvation (By similarity). Early embryonic lethality due to cell cycle progression failure, termination of cell division, and, eventually, embryonic death during the preimplantation stage. Belongs to the WD repeat cdt2 family. Sequence=BAE36376.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BC060208; Type=Frameshift; Evidence=; protein polyubiquitination ubiquitin-protein transferase activity nucleus chromosome nucleolus cytoplasm centrosome microtubule organizing center cytosol cytoskeleton DNA replication ubiquitin-dependent protein catabolic process protein monoubiquitination cellular response to DNA damage stimulus response to UV positive regulation of G2/M transition of mitotic cell cycle membrane protein ubiquitination translesion synthesis Cul4A-RING E3 ubiquitin ligase complex Cul4B-RING E3 ubiquitin ligase complex nuclear membrane positive regulation of protein catabolic process rhythmic process regulation of cell cycle signal transduction involved in G2 DNA damage checkpoint Cul4-RING E3 ubiquitin ligase complex uc007eck.1 uc007eck.2 uc007eck.3 uc007eck.4 
ENSMUST00000027940.6 Pacc1 ENSMUST00000027940.6 proton activated chloride channel 1 (from RefSeq NM_025864.4) ENSMUST00000027940.1 ENSMUST00000027940.2 ENSMUST00000027940.3 ENSMUST00000027940.4 ENSMUST00000027940.5 NM_025864 PACC1_MOUSE Pacc1 Q9D771 Tmem206 uc007ech.1 uc007ech.2 uc007ech.3 Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH (PubMed:31023925). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925). Cell membrane ; Multi-pass membrane protein Mice are viable and appear mostly normal (PubMed:31023925). Cortical neurons completely lack proton-activated chloride channel activity (PubMed:31023925). Neurons are partially but significantly protected from delayed cell death induced by 1-hour acid treatment (PubMed:31023925). Belongs to the proton-activated chloride channel family. chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport membrane integral component of membrane ion transmembrane transport chloride channel complex pH-gated chloride channel activity chloride transmembrane transport uc007ech.1 uc007ech.2 uc007ech.3 
ENSMUST00000027943.6 Batf3 ENSMUST00000027943.6 basic leucine zipper transcription factor, ATF-like 3 (from RefSeq NM_030060.2) BATF3_MOUSE ENSMUST00000027943.1 ENSMUST00000027943.2 ENSMUST00000027943.3 ENSMUST00000027943.4 ENSMUST00000027943.5 NM_030060 Q9D275 uc007ecd.1 uc007ecd.2 uc007ecd.3 AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8- alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens. Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN. Nucleus Highly expressed in CD8-alpha(+) classical dendritic cells (cDCs), with low to absent expression in other immune cells and non-immune tissues. Selective loss of CD8-alpha(+) classical dendritic cells (cDCs) and CD103(+) dendritic cells, without abnormalities in other hematopoietic cell types or architecture. Dendritic cells are defective in cross-presentation, and mice lack virus-specific CD8(+) T-cell responses to West Nile virus. Mice also show reduced priming of CD8 T-cells after pulmonary Sendai virus infection, with increased pulmonary inflammation. Mice are extremely susceptible to T.gondii infection, with decreased production of interleukin-12 (IL12) and interferon-gamma. In contrast, mice are more resistant to L.monocytogenes infection. The increased protection toward L.monocytogenes infection in mice lacking Batf3 suggests that CD8-alpha(+) classical dendritic cells (cDCs) and CD103(+) dendritic cells are an entry point for infection by L.monocytogenes. Belongs to the bZIP family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter response to virus cell differentiation myeloid dendritic cell differentiation dendritic cell differentiation uc007ecd.1 uc007ecd.2 uc007ecd.3 
ENSMUST00000027947.13 Angel2 ENSMUST00000027947.13 angel homolog 2, transcript variant 2 (from RefSeq NM_001199020.1) ANGE2_MOUSE D1Ertd396e D1Ertd654e ENSMUST00000027947.1 ENSMUST00000027947.10 ENSMUST00000027947.11 ENSMUST00000027947.12 ENSMUST00000027947.2 ENSMUST00000027947.3 ENSMUST00000027947.4 ENSMUST00000027947.5 ENSMUST00000027947.6 ENSMUST00000027947.7 ENSMUST00000027947.8 ENSMUST00000027947.9 MNCb-4273 NM_001199020 Q3TEH1 Q3TL94 Q8BTT0 Q8K1C0 Q9JJB0 uc007ebj.1 uc007ebj.2 uc007ebj.3 uc007ebj.4 Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8K1C0-1; Sequence=Displayed; Name=2; IsoId=Q8K1C0-2; Sequence=VSP_028218; Name=3; IsoId=Q8K1C0-3; Sequence=VSP_028217; Name=4; IsoId=Q8K1C0-4; Sequence=VSP_028217, VSP_028220, VSP_028221; Name=5; IsoId=Q8K1C0-5; Sequence=VSP_028217, VSP_028219, VSP_028221; Belongs to the CCR4/nocturin family. 3'-5'-exoribonuclease activity mRNA 3'-UTR binding cytoplasm Cajal body negative regulation of mitotic cell cycle 3'-UTR-mediated mRNA stabilization RNA phosphodiester bond hydrolysis, exonucleolytic uc007ebj.1 uc007ebj.2 uc007ebj.3 uc007ebj.4 
ENSMUST00000027952.12 Plxna2 ENSMUST00000027952.12 plexin A2 (from RefSeq NM_008882.2) ENSMUST00000027952.1 ENSMUST00000027952.10 ENSMUST00000027952.11 ENSMUST00000027952.2 ENSMUST00000027952.3 ENSMUST00000027952.4 ENSMUST00000027952.5 ENSMUST00000027952.6 ENSMUST00000027952.7 ENSMUST00000027952.8 ENSMUST00000027952.9 Kiaa0463 NM_008882 P70207 PLXA2_MOUSE Q6NVE6 Q6PHN4 Q80TZ7 Q8R1I4 uc007een.1 uc007een.2 uc007een.3 uc007een.4 Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Homodimer. Interacts with RND1 (By similarity). Interacts directly with NRP1 and NRP2. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. P70207; P97333: Nrp1; NbExp=3; IntAct=EBI-771272, EBI-1555129; P70207; P70207: Plxna2; NbExp=4; IntAct=EBI-771272, EBI-771272; P70207; O35464-1: Sema6a; NbExp=5; IntAct=EBI-771272, EBI-15880936; Cell membrane ingle-pass type I membrane protein Belongs to the plexin family. Sequence=AAH68155.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAA13189.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; somitogenesis semaphorin receptor complex protein binding plasma membrane integral component of plasma membrane negative regulation of cell adhesion signal transduction cell surface receptor signaling pathway regulation of cell shape membrane integral component of membrane semaphorin receptor activity neural tube development cerebellar granule cell precursor tangential migration regulation of cell migration identical protein binding regulation of GTPase activity positive regulation of axonogenesis centrosome localization pharyngeal system development limb bud formation semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway involved in axon guidance uc007een.1 uc007een.2 uc007een.3 uc007een.4 
ENSMUST00000027956.9 Suv39h2 ENSMUST00000027956.9 suppressor of variegation 3-9 2, transcript variant 1 (from RefSeq NM_022724.4) A0A0R4J074 A0A0R4J074_MOUSE ENSMUST00000027956.1 ENSMUST00000027956.2 ENSMUST00000027956.3 ENSMUST00000027956.4 ENSMUST00000027956.5 ENSMUST00000027956.6 ENSMUST00000027956.7 ENSMUST00000027956.8 NM_022724 Suv39h2 uc008ied.1 uc008ied.2 uc008ied.3 uc008ied.4 Reaction=L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60276, Rhea:RHEA-COMP:15538, Rhea:RHEA- COMP:15546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.355; Evidence=; Chromosome, centromere Nucleus Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. negative regulation of transcription from RNA polymerase II promoter chromatin nucleus chromosome chromatin organization chromatin assembly or disassembly chromatin remodeling methyltransferase activity zinc ion binding transferase activity histone-lysine N-methyltransferase activity methylation histone lysine methylation metal ion binding histone methyltransferase activity (H3-K9 specific) histone H3-K9 methylation cellular response to hypoxia S-adenosyl-L-methionine binding uc008ied.1 uc008ied.2 uc008ied.3 uc008ied.4 
ENSMUST00000027959.11 Cfap126 ENSMUST00000027959.11 cilia and flagella associated protein 126, transcript variant 3 (from RefSeq NM_001379427.1) Cfap126 ENSMUST00000027959.1 ENSMUST00000027959.10 ENSMUST00000027959.2 ENSMUST00000027959.3 ENSMUST00000027959.4 ENSMUST00000027959.5 ENSMUST00000027959.6 ENSMUST00000027959.7 ENSMUST00000027959.8 ENSMUST00000027959.9 FLTOP_MOUSE Fltp NM_001379427 Q6P8X9 Q9DAJ1 uc007dna.1 uc007dna.2 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (By similarity). Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear. Interacts with DLG3. Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, cilium axoneme Apical cell membrane Note=Localizes to the apical cell membrane, the basal body and the primary cilium in monociliated node cells. Expressed in mono- and multiciliated tissues during planar cell polarity acquisition. First detected in the embryonic node at 7.5 dpc. At 8.5-13.5 dpc, strong expression is detected in tissues that are either mono- or multiciliated, such as the eye, notochord, floor plate of the neural tube and all 4 choroid plexi. Expressed during development and early postnatal life in all 6 sensory regions of the inner ear. mice were born at the expected Mendelian ratio and are viable and fertile but show basal body docking and ciliogenesis defects in multiciliated lung cells. Belongs to the Flattop family. Sequence=BAB24245.1; Type=Frameshift; Evidence=; protein binding cytoplasm cytoskeleton plasma membrane cilium membrane apical plasma membrane cell projection organization ciliary basal body cell projection cilium organization uc007dna.1 uc007dna.2 
ENSMUST00000027961.12 Hspa14 ENSMUST00000027961.12 heat shock protein 14, transcript variant 1 (from RefSeq NM_015765.2) A2AJH7 ENSMUST00000027961.1 ENSMUST00000027961.10 ENSMUST00000027961.11 ENSMUST00000027961.2 ENSMUST00000027961.3 ENSMUST00000027961.4 ENSMUST00000027961.5 ENSMUST00000027961.6 ENSMUST00000027961.7 ENSMUST00000027961.8 ENSMUST00000027961.9 HSP7E_MOUSE Hsp70-4 NM_015765 Q3U5W7 Q60637 Q99M31 uc008ief.1 uc008ief.2 uc008ief.3 Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding- competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity). Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99M31-1; Sequence=Displayed; Name=2; IsoId=Q99M31-2; Sequence=VSP_026032; Belongs to the heat shock protein 70 family. nucleotide binding cytoplasmic translation ATP binding cytoplasm cytosol ribosome polysome regulation of translational fidelity response to unfolded protein ATPase activity heat shock protein binding cellular response to heat cellular response to unfolded protein protein refolding ATPase activity, coupled protein binding involved in protein folding unfolded protein binding chaperone mediated protein folding requiring cofactor misfolded protein binding uc008ief.1 uc008ief.2 uc008ief.3 
ENSMUST00000027970.14 Dusp12 ENSMUST00000027970.14 dual specificity phosphatase 12, transcript variant 1 (from RefSeq NM_023173.2) DUS12_MOUSE ENSMUST00000027970.1 ENSMUST00000027970.10 ENSMUST00000027970.11 ENSMUST00000027970.12 ENSMUST00000027970.13 ENSMUST00000027970.2 ENSMUST00000027970.3 ENSMUST00000027970.4 ENSMUST00000027970.5 ENSMUST00000027970.6 ENSMUST00000027970.7 ENSMUST00000027970.8 ENSMUST00000027970.9 NM_023173 Q9D0T2 Q9EQD3 uc007dml.1 uc007dml.2 Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Monomer. Nucleus Cytoplasm, cytosol Note=Primarily nuclear. Detected in a mesh-like pattern in the cytosol. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm cytosol protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity zinc ion binding dephosphorylation hydrolase activity phosphatase activity kinase binding positive regulation of glucokinase activity peptidyl-tyrosine dephosphorylation metal ion binding uc007dml.1 uc007dml.2 
ENSMUST00000027973.14 Sephs1 ENSMUST00000027973.14 selenophosphate synthetase 1, transcript variant 2 (from RefSeq NM_175400.6) ENSMUST00000027973.1 ENSMUST00000027973.10 ENSMUST00000027973.11 ENSMUST00000027973.12 ENSMUST00000027973.13 ENSMUST00000027973.2 ENSMUST00000027973.3 ENSMUST00000027973.4 ENSMUST00000027973.5 ENSMUST00000027973.6 ENSMUST00000027973.7 ENSMUST00000027973.8 ENSMUST00000027973.9 NM_175400 Q8BH69 SPS1_MOUSE Sps1 uc008ifb.1 uc008ifb.2 uc008ifb.3 Synthesizes selenophosphate from selenide and ATP. Reaction=ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate; Xref=Rhea:RHEA:18737, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16144, ChEBI:CHEBI:29317, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; EC=2.7.9.3; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per monomer. ; Homodimer. Cell membrane ; Peripheral membrane protein Nucleus membrane ; Peripheral membrane protein Belongs to the selenophosphate synthase 1 family. Class II subfamily. The conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr. However, as function in selenoprotein synthesis is probable, it is possible Cys-31 is the active site. nucleotide binding selenium compound metabolic process selenide, water dikinase activity ATP binding nucleus cytoplasm plasma membrane membrane selenocysteine biosynthetic process kinase activity phosphorylation transferase activity nuclear membrane identical protein binding protein homodimerization activity protein heterodimerization activity tRNA seleno-modification uc008ifb.1 uc008ifb.2 uc008ifb.3 
ENSMUST00000027974.7 Atf6 ENSMUST00000027974.7 activating transcription factor 6 (from RefSeq NM_001081304.1) ATF6A_MOUSE B2RU98 ENSMUST00000027974.1 ENSMUST00000027974.2 ENSMUST00000027974.3 ENSMUST00000027974.4 ENSMUST00000027974.5 ENSMUST00000027974.6 F6VAN0 NM_001081304 Q8BZ84 uc007dmj.1 uc007dmj.2 uc007dmj.3 [Cyclic AMP-dependent transcription factor ATF-6 alpha]: Precursor of the transcription factor form (Processed cyclic AMP- dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR). [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR. Binds DNA on the 5'- CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT- N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina. Interacts with XBP1 isoform 2; the interaction occurs in a ER stress-dependent manner. Interacts with LACC1. [Cyclic AMP-dependent transcription factor ATF-6 alpha]: Interacts with THBS4 (via EGF-like 3; calcium-binding domain) which facilitates its processing, activation and nuclear translocation (PubMed:22682248). Interacts (via lumenal domain) with THBS1 (PubMed:22682248). [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Homodimer and heterodimer with ATF6-beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). Interacts also with the transcription factors GTF2I, YY1 and SRF. F6VAN0; Q3U182: Crtc2; NbExp=2; IntAct=EBI-6171558, EBI-8018890; F6VAN0; Q9Z1T2: Thbs4; NbExp=3; IntAct=EBI-6171558, EBI-6171531; Endoplasmic reticulum membrane ; Single-pass type II membrane protein Golgi apparatus membrane ; Single-pass type II membrane protein Note=Translocates from the endoplasmic reticulum to the Golgi, where it is processed. [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Nucleus Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus (PubMed:22682248). THBS4 promotes its nuclear shuttling (PubMed:22682248). The basic domain functions as a nuclear localization signal. The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE. During unfolded protein response, a fragment of approximately 50 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases (By similarity). N-glycosylated. The glycosylation status may serve as a sensor for ER homeostasis, resulting in ATF6 activation to trigger the unfolded protein response (UPR) (By similarity). Ubiquitinated by RNF186 at Lys-139, which is required for pattern recognition receptor-induced unfolded protein response-associated outcomes. Animals have normal retinal morphology and function at a young age but develop rod and cone dysfunction with increasing age. Belongs to the bZIP family. ATF subfamily. Sequence=BAC29389.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding eye development DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus regulation of transcription, DNA-templated response to unfolded protein visual perception membrane integral component of membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum unfolded protein response ubiquitin protein ligase binding cAMP response element binding identical protein binding positive regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity positive regulation of ATF6-mediated unfolded protein response positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress uc007dmj.1 uc007dmj.2 uc007dmj.3 
ENSMUST00000027975.8 Phyh ENSMUST00000027975.8 phytanoyl-CoA hydroxylase (from RefSeq NM_010726.2) ENSMUST00000027975.1 ENSMUST00000027975.2 ENSMUST00000027975.3 ENSMUST00000027975.4 ENSMUST00000027975.5 ENSMUST00000027975.6 ENSMUST00000027975.7 NM_010726 Phyh Q3TPC7 Q3TPC7_MOUSE uc008ifd.1 uc008ifd.2 uc008ifd.3 uc008ifd.4 Belongs to the PhyH family. fatty acid alpha-oxidation mitochondrion peroxisome 2-oxoglutarate metabolic process isoprenoid metabolic process ferrous iron binding 2-oxobutyrate catabolic process carboxylic acid binding cofactor binding phytanoyl-CoA dioxygenase activity methyl-branched fatty acid metabolic process uc008ifd.1 uc008ifd.2 uc008ifd.3 uc008ifd.4 
ENSMUST00000027979.14 Uhmk1 ENSMUST00000027979.14 U2AF homology motif (UHM) kinase 1, transcript variant 1 (from RefSeq NM_010633.4) ENSMUST00000027979.1 ENSMUST00000027979.10 ENSMUST00000027979.11 ENSMUST00000027979.12 ENSMUST00000027979.13 ENSMUST00000027979.2 ENSMUST00000027979.3 ENSMUST00000027979.4 ENSMUST00000027979.5 ENSMUST00000027979.6 ENSMUST00000027979.7 ENSMUST00000027979.8 ENSMUST00000027979.9 Kis Kist NM_010633 P97343 Q61775 Q9CYT1 UHMK1_MOUSE uc007dma.1 uc007dma.2 uc007dma.3 Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Interacts with PAM and CDKN1B/p27Kip1 (By similarity). Interacts with stathmin. Nucleus Note=Mostly nuclear. By serum growth factors. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding nucleic acid binding RNA binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm Golgi apparatus protein phosphorylation cell cycle arrest kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation enzyme binding axon neuron projection development dendrite cytoplasm ribonucleoprotein complex binding positive regulation of translational initiation protein autophosphorylation regulation of protein export from nucleus neuronal ribonucleoprotein granule uc007dma.1 uc007dma.2 uc007dma.3 
ENSMUST00000027981.8 Uap1 ENSMUST00000027981.8 UDP-N-acetylglucosamine pyrophosphorylase 1, transcript variant 2 (from RefSeq NM_133806.7) A0A0R4J085 A0A0R4J085_MOUSE ENSMUST00000027981.1 ENSMUST00000027981.2 ENSMUST00000027981.3 ENSMUST00000027981.4 ENSMUST00000027981.5 ENSMUST00000027981.6 ENSMUST00000027981.7 NM_133806 Uap1 uc007dlw.1 uc007dlw.2 uc007dlw.3 uc007dlw.4 uridylyltransferase activity uc007dlw.1 uc007dlw.2 uc007dlw.3 uc007dlw.4 
ENSMUST00000027988.8 Ccdc3 ENSMUST00000027988.8 coiled-coil domain containing 3 (from RefSeq NM_028804.1) CCDC3_MOUSE ENSMUST00000027988.1 ENSMUST00000027988.2 ENSMUST00000027988.3 ENSMUST00000027988.4 ENSMUST00000027988.5 ENSMUST00000027988.6 ENSMUST00000027988.7 NM_028804 Q9D6Y1 uc008ifo.1 uc008ifo.2 uc008ifo.3 uc008ifo.4 Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (By similarity). Positively regulates lipid accumulation in adipose cells (PubMed:25605713). Homodimer. Secreted Expressed in aorta and adipose tissue. Enriched in mature adipocytes. Over-expressed in adipose tissue from either hormonally-induced or nutritionally-regulated obese mice models. N-glycosylated. Mice exhibit a lean phenotype with reduced fat mass and smaller adipocyte size compared to wild type mice. Adipose tissue exhibit decreased levels of lipogenic genes, such as fatty-acid synthase (FASN), acetyl-CoA carboxylase (ACACA) and diacylglycerol O- acyltransferase-2 (DGAT2). Mice exhibit strongly inhibited age-related hepatic steatosis and decreased number of inflammatory cells in epididymal adipose tissue. molecular_function extracellular region endoplasmic reticulum negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of fat cell differentiation positive regulation of lipid biosynthetic process uc008ifo.1 uc008ifo.2 uc008ifo.3 uc008ifo.4 
ENSMUST00000027989.13 Hsd17b7 ENSMUST00000027989.13 hydroxysteroid (17-beta) dehydrogenase 7, transcript variant 2 (from RefSeq NM_010476.4) 17hsd7 DHB7_MOUSE ENSMUST00000027989.1 ENSMUST00000027989.10 ENSMUST00000027989.11 ENSMUST00000027989.12 ENSMUST00000027989.2 ENSMUST00000027989.3 ENSMUST00000027989.4 ENSMUST00000027989.5 ENSMUST00000027989.6 ENSMUST00000027989.7 ENSMUST00000027989.8 ENSMUST00000027989.9 NM_010476 O88736 Q8K5C9 Q921L1 uc007dlp.1 uc007dlp.2 uc007dlp.3 Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:9658408, PubMed:12732193, PubMed:12829805, PubMed:20659585). Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1)to a more potent estrogen, 17beta-estradiol (E2) (PubMed:9658408, PubMed:12732193). Converts moderately dihydrotestosterone (DHT) to their inactive forms 5a-androstane-3beta,17b-diol and 5alpha-androstane-3alpha,17beta-diol (PubMed:12732193). Does not metabolize progesterone (PubMed:12732193). Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:12829805, PubMed:20659585). Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH; Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:24618; Evidence=; Reaction=a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH; Xref=Rhea:RHEA:34787, ChEBI:CHEBI:15378, ChEBI:CHEBI:36836, ChEBI:CHEBI:47788, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.270; Evidence= PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:34789; Evidence=; Reaction=3-dehydro-4alpha-methylzymosterol + H(+) + NADPH = 4alpha- methylzymosterol + NADP(+); Xref=Rhea:RHEA:36379, ChEBI:CHEBI:1949, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:136486; EC=1.1.1.270; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36380; Evidence=; Reaction=H(+) + NADPH + zymosterone = NADP(+) + zymosterol; Xref=Rhea:RHEA:33459, ChEBI:CHEBI:15378, ChEBI:CHEBI:18252, ChEBI:CHEBI:52386, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33460; Evidence=; Reaction=4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH = 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+); Xref=Rhea:RHEA:46832, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:87050, ChEBI:CHEBI:87051; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46833; Evidence=; Reaction=4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha- methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH; Xref=Rhea:RHEA:18409, ChEBI:CHEBI:15378, ChEBI:CHEBI:16495, ChEBI:CHEBI:18378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.270; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18411; Evidence=; Reaction=5alpha-cholest-8-en-3-one + H(+) + NADPH = 5alpha-cholest-8- en-3beta-ol + NADP(+); Xref=Rhea:RHEA:46852, ChEBI:CHEBI:15378, ChEBI:CHEBI:16608, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:87056; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46853; Evidence=; Reaction=5alpha-androstane-3alpha,17beta-diol + NADP(+) = 17beta- hydroxy-5alpha-androstan-3-one + H(+) + NADPH; Xref=Rhea:RHEA:42116, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:36713, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42118; Evidence=; Reaction=5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta- hydroxy-5alpha-androstan-3-one + H(+) + NADPH; Xref=Rhea:RHEA:16297, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:18329, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.210; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:16299; Evidence=; Kinetic parameters: KM=2.28 uM for estrone ; KM=12.87 uM for 17beta-estradiol ; KM=1.19 uM for estrone ; Vmax=556 pmol/min/mg enzyme with estrone as substrate ; Vmax=616 pmol/min/mg enzyme with 17beta-estradiol as substrate ; Steroid biosynthesis; estrogen biosynthesis. Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6. Binds to the short form of prolactin receptor. Endoplasmic reticulum membrane ; Single-pass membrane protein Note=Colocalizes with HMGCR in a wide range of tissues during embryonic development. Most abundant in ovaries of pregnant animals. Present also in nonpregnant animals in ovaries, mammary gland liver, kidney and testis. Phosphorylated. Death at embryonic day 10.5. Embryonic lethality is caused by severe brain malformation and heart defect. Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. 3-keto sterol reductase activity estradiol 17-beta-dehydrogenase activity prolactin receptor binding endoplasmic reticulum plasma membrane lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process estrogen biosynthetic process nervous system development membrane integral component of membrane oxidoreductase activity cell differentiation embryonic skeletal system development oxidation-reduction process uc007dlp.1 uc007dlp.2 uc007dlp.3 
ENSMUST00000027991.12 Rgs4 ENSMUST00000027991.12 regulator of G-protein signaling 4 (from RefSeq NM_009062.3) ENSMUST00000027991.1 ENSMUST00000027991.10 ENSMUST00000027991.11 ENSMUST00000027991.2 ENSMUST00000027991.3 ENSMUST00000027991.4 ENSMUST00000027991.5 ENSMUST00000027991.6 ENSMUST00000027991.7 ENSMUST00000027991.8 ENSMUST00000027991.9 NM_009062 Q5D078 Q5D078_MOUSE Rgs4 uc007dln.1 uc007dln.2 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)- alpha-1 is inhibited by palmitoylation of the G-protein. G-protein alpha-subunit binding response to amphetamine GTPase activator activity nucleus cytoplasm cytosol plasma membrane G-protein coupled receptor signaling pathway brain development positive regulation of heart rate membrane macromolecular complex response to cocaine response to morphine positive regulation of GTPase activity response to ethanol negative regulation of G-protein coupled receptor protein signaling pathway regulation of calcium ion transport negative regulation of dopamine receptor signaling pathway negative regulation of cell growth involved in cardiac muscle cell development negative regulation of glycine import regulation of potassium ion transmembrane transport negative regulation of potassium ion transmembrane transport dorsal root ganglion development positive regulation of excitatory postsynaptic potential uc007dln.1 uc007dln.2 
ENSMUST00000027992.3 Enkur ENSMUST00000027992.3 enkurin, TRPC channel interacting protein (from RefSeq NM_027728.2) ENKUR_MOUSE ENSMUST00000027992.1 ENSMUST00000027992.2 NM_027728 Q6SP97 uc008ina.1 uc008ina.2 Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (PubMed:15385169). Microtubule inner protein (MIP) part of the dynein- decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Binds calmodulin via its IQ domain. Interacts with TRPC1, TRPC2, TRPC5, but not TRPC3 (PubMed:15385169). Interacts with CFAP45 (By similarity). Cytoplasm, cytoskeleton, cilium axoneme Cell projection, cilium, flagellum Note=Sperm acrosomal crescent and flagellar principal piece. High expression in testis and vomeronasal organ and lower expression in ovary, heart, lung, and brain. Not expressed in other tissues. The IQ motif is involved in calmodulin binding. acrosomal vesicle protein binding calmodulin binding cilium SH3 domain binding motile cilium cell projection sperm principal piece uc008ina.1 uc008ina.2 
ENSMUST00000027997.9 Rgs5 ENSMUST00000027997.9 regulator of G-protein signaling 5, transcript variant 1 (from RefSeq NM_009063.5) ENSMUST00000027997.1 ENSMUST00000027997.2 ENSMUST00000027997.3 ENSMUST00000027997.4 ENSMUST00000027997.5 ENSMUST00000027997.6 ENSMUST00000027997.7 ENSMUST00000027997.8 NM_009063 O08850 Q543B1 Q9D0Z2 RGS5_MOUSE uc007dlm.1 uc007dlm.2 uc007dlm.3 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. Cytoplasm Membrane Expressed in heart and muscle. GTPase activator activity cytoplasm cytosol signal transduction G-protein coupled receptor signaling pathway negative regulation of signal transduction membrane positive regulation of GTPase activity negative regulation of vascular smooth muscle cell proliferation uc007dlm.1 uc007dlm.2 uc007dlm.3 
ENSMUST00000028004.11 Aldh9a1 ENSMUST00000028004.11 aldehyde dehydrogenase 9, subfamily A1, transcript variant 1 (from RefSeq NM_019993.4) AL9A1_MOUSE Aldh9a1 ENSMUST00000028004.1 ENSMUST00000028004.10 ENSMUST00000028004.2 ENSMUST00000028004.3 ENSMUST00000028004.4 ENSMUST00000028004.5 ENSMUST00000028004.6 ENSMUST00000028004.7 ENSMUST00000028004.8 ENSMUST00000028004.9 NM_019993 Q3U367 Q9JLJ2 uc007dkx.1 uc007dkx.2 uc007dkx.3 Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines. Reaction=4-(trimethylamino)butanal + H2O + NAD(+) = 4- (trimethylamino)butanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:17985, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16244, ChEBI:CHEBI:18020, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.47; Evidence=; Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence=; Reaction=4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:19105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58264, ChEBI:CHEBI:59888; EC=1.2.1.19; Evidence=; Reaction=formaldehyde + H2O + NAD(+) = formate + 2 H(+) + NADH; Xref=Rhea:RHEA:16425, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:16842, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.46; Evidence=; Reaction=acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH; Xref=Rhea:RHEA:25294, ChEBI:CHEBI:15343, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence=; Reaction=H2O + imidazole-4-acetaldehyde + NAD(+) = 2 H(+) + imidazole- 4-acetate + NADH; Xref=Rhea:RHEA:31059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27398, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57969; Evidence=; Reaction=acrolein + H2O + NAD(+) = acrylate + 2 H(+) + NADH; Xref=Rhea:RHEA:69084, ChEBI:CHEBI:15368, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37080, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) = (5- hydroxyindol-3-yl)acetate + 2 H(+) + NADH; Xref=Rhea:RHEA:31215, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:50157, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62622; Evidence=; Reaction=3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) = 3,4- dihydroxyphenylacetate + 2 H(+) + NADH; Xref=Rhea:RHEA:69080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17612, ChEBI:CHEBI:27978, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=H2O + NAD(+) + spermine monoaldehyde = 2 H(+) + N-(2- carboxyethyl)spermidine + NADH; Xref=Rhea:RHEA:69168, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:180903, ChEBI:CHEBI:180913; Evidence=; Reaction=H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate; Xref=Rhea:RHEA:67256, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17153, ChEBI:CHEBI:17272, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=butanal + H2O + NAD(+) = butanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:69088, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15743, ChEBI:CHEBI:17968, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=H2O + NAD(+) + pentanal = 2 H(+) + NADH + pentanoate; Xref=Rhea:RHEA:69092, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:31011, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:84069; Evidence=; Reaction=H2O + hexanal + NAD(+) = 2 H(+) + hexanoate + NADH; Xref=Rhea:RHEA:67276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:88528; Evidence=; Amine and polyamine biosynthesis; carnitine biosynthesis. Homotetramer. Cytoplasm, cytosol Cytoplasm Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=Q9JLJ2-1; Sequence=Displayed; Name=2; IsoId=Q9JLJ2-2; Sequence=VSP_061582; [Isoform 2]: Produced by alternative initiation. Contains a predicted signal peptide at positions 1-21. Belongs to the aldehyde dehydrogenase family. aldehyde dehydrogenase (NAD) activity cytoplasm mitochondrion cytosol cellular aldehyde metabolic process carnitine metabolic process oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor aminobutyraldehyde dehydrogenase activity neurotransmitter biosynthetic process protein homodimerization activity amine binding glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity carnitine biosynthetic process 4-trimethylammoniobutyraldehyde dehydrogenase activity NAD binding protein homotetramerization oxidation-reduction process uc007dkx.1 uc007dkx.2 uc007dkx.3 
ENSMUST00000028005.3 Mgst3 ENSMUST00000028005.3 microsomal glutathione S-transferase 3 (from RefSeq NM_025569.2) ENSMUST00000028005.1 ENSMUST00000028005.2 MGST3_MOUSE Mgst3 NM_025569 Q3UXC5 Q9CPU4 Q9D834 uc007dky.1 uc007dky.2 uc007dky.3 Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids. Catalyzes the Michael addition reaction of reduced glutathione (GSH) to electrophilic eicosanoids to form GSH adducts, as part of detoxification or metabolic shunt processes. Mediates GSH conjugation to leukotriene A4 to form the sulfidopeptide leukotriene C4. Metabolizes cyclopentenone prostanoids, specifically mediates GSH addition at C9 within the cyclopentenone ring of 15-deoxy-Delta12,14-prostaglandin J2 (15dPGJ2) to form 15dPGJ2- glutathione. L-cysteine can not substitute for GSH. Catalyzes the reduction of eicosanoid peroxides to yield eicosanoid hydroxides. Reaction=leukotriene C4 = glutathione + leukotriene A4; Xref=Rhea:RHEA:17617, ChEBI:CHEBI:57463, ChEBI:CHEBI:57925, ChEBI:CHEBI:57973; EC=4.4.1.20; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17619; Evidence=; Reaction=15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15- deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione; Xref=Rhea:RHEA:75963, ChEBI:CHEBI:57925, ChEBI:CHEBI:85236, ChEBI:CHEBI:194498; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75964; Evidence=; Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48620, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90632; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48621; Evidence=; Lipid metabolism; leukotriene C4 biosynthesis. Lipid metabolism; arachidonate metabolism. Mitochondrion outer membrane ; Multi-pass membrane protein Belongs to the MAPEG family. glutathione transferase activity leukotriene-C4 synthase activity glutathione peroxidase activity nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process response to organonitrogen compound membrane integral component of membrane oxidoreductase activity transferase activity leukotriene biosynthetic process organelle membrane intracellular membrane-bounded organelle oxidation-reduction process cellular oxidant detoxification uc007dky.1 uc007dky.2 uc007dky.3 
ENSMUST00000028010.9 Fmo3 ENSMUST00000028010.9 flavin containing monooxygenase 3 (from RefSeq NM_008030.2) ENSMUST00000028010.1 ENSMUST00000028010.2 ENSMUST00000028010.3 ENSMUST00000028010.4 ENSMUST00000028010.5 ENSMUST00000028010.6 ENSMUST00000028010.7 ENSMUST00000028010.8 Fmo3 NM_008030 Q3UEN4 Q3UEN4_MOUSE uc007dhe.1 uc007dhe.2 uc007dhe.3 uc007dhe.4 Reaction=(S)-nicotine + NADPH + O2 = H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide; Xref=Rhea:RHEA:58720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:59806, ChEBI:CHEBI:142660; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58721; Evidence=; Reaction=H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N- dimethylaniline N-oxide + NADP(+); Xref=Rhea:RHEA:24468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16269, ChEBI:CHEBI:17735, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24469; Evidence=; Reaction=H(+) + hypotaurine + NADPH + O2 = H2O + NADP(+) + taurine; Xref=Rhea:RHEA:69819, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:57853, ChEBI:CHEBI:58349, ChEBI:CHEBI:507393; EC=1.14.13.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69820; Evidence=; Reaction=NADPH + O2 + trimethylamine = H2O + NADP(+) + trimethylamine N-oxide; Xref=Rhea:RHEA:31979, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:15724, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58389; EC=1.14.13.148; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31980; Evidence=; Reaction=albendazole + H(+) + NADPH + O2 = albendazole S-oxide + H2O + NADP(+); Xref=Rhea:RHEA:10796, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16664, ChEBI:CHEBI:16959, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.32; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10797; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Endoplasmic reticulum membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein Microsome membrane ; Single-pass membrane protein Belongs to the FMO family. monooxygenase activity N,N-dimethylaniline monooxygenase activity endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane oxidoreductase activity organelle membrane intracellular membrane-bounded organelle flavin adenine dinucleotide binding NADP binding oxidation-reduction process uc007dhe.1 uc007dhe.2 uc007dhe.3 uc007dhe.4 
ENSMUST00000028017.16 Mettl13 ENSMUST00000028017.16 methyltransferase 13, eEF1A lysine and N-terminal methyltransferase, transcript variant 4 (from RefSeq NR_184652.1) EEF1AKNMT EFNMT_MOUSE ENSMUST00000028017.1 ENSMUST00000028017.10 ENSMUST00000028017.11 ENSMUST00000028017.12 ENSMUST00000028017.13 ENSMUST00000028017.14 ENSMUST00000028017.15 ENSMUST00000028017.2 ENSMUST00000028017.3 ENSMUST00000028017.4 ENSMUST00000028017.5 ENSMUST00000028017.6 ENSMUST00000028017.7 ENSMUST00000028017.8 ENSMUST00000028017.9 FEAT Mettl13 NR_184652 Q3TF24 Q3TFY3 Q69ZX4 Q8BWN2 Q8BX81 Q91YR5 uc007dgh.1 uc007dgh.2 uc007dgh.3 uc007dgh.4 Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation (By similarity). Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2' (By similarity). Via its N- terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55' (By similarity). Has no activity towards core histones H2A, H2B, H3 and H4 (By similarity). Negatively regulates cell proliferation at G1/S transition via transcriptional suppression of cell cycle regulatory genes such as CDK4 and CDK6 (By similarity). Reaction=L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:51736, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13053, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence=; Reaction=N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54196, Rhea:RHEA-COMP:13053, Rhea:RHEA-COMP:13827, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; Reaction=N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl- L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L- glutamyl-[protein] + 3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:58440, Rhea:RHEA-COMP:15140, Rhea:RHEA-COMP:15143, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:142597, ChEBI:CHEBI:142600; Evidence=; Forms a tripartite complex containing GAB1, METTL13 and SPRY2 (By similarity). Within the complex interacts with GAB1 and SPRY2 (By similarity). Cytoplasm Nucleus Mitochondrion Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q91YR5-3; Sequence=Displayed; Name=2; IsoId=Q91YR5-1; Sequence=VSP_013925, VSP_013926; Name=3; IsoId=Q91YR5-2; Sequence=VSP_013923, VSP_013924; Expressed in the inner ear (at protein level) (PubMed:29408807). Expression is detected in the cochlear duct, spiral limbus region, efferent and afferent nerves, and in spiral ganglion neurons (at protein level) (PubMed:29408807). Belongs to the methyltransferase superfamily. Sequence=BAD32322.1; Type=Erroneous initiation; Evidence=; molecular_function catalytic activity cellular_component metabolic process methyltransferase activity transferase activity methylation uc007dgh.1 uc007dgh.2 uc007dgh.3 uc007dgh.4 
ENSMUST00000028020.11 Myoc ENSMUST00000028020.11 myocilin (from RefSeq NM_010865.3) ENSMUST00000028020.1 ENSMUST00000028020.10 ENSMUST00000028020.2 ENSMUST00000028020.3 ENSMUST00000028020.4 ENSMUST00000028020.5 ENSMUST00000028020.6 ENSMUST00000028020.7 ENSMUST00000028020.8 ENSMUST00000028020.9 Myoc NM_010865 Q05AC1 Q05AC1_MOUSE uc007dgm.1 uc007dgm.2 uc007dgm.3 uc007dgm.4 Cell projection, cilium Cytoplasmic vesicle Endoplasmic reticulum Membrane Mitochondrion intermembrane space Mitochondrion outer membrane Rough endoplasmic reticulum Secreted, extracellular exosome Secreted, extracellular space, extracellular matrix Vesicle Lacks conserved residue(s) required for the propagation of feature annotation. osteoblast differentiation regulation of cell-matrix adhesion negative regulation of cell-matrix adhesion fibronectin binding frizzled binding extracellular space mitochondrial outer membrane mitochondrial inner membrane mitochondrial intermembrane space Golgi apparatus positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of cell migration neuron projection development cytoplasmic vesicle myosin light chain binding negative regulation of Rho protein signal transduction non-canonical Wnt signaling pathway via JNK cascade regulation of MAPK cascade regulation of stress fiber assembly positive regulation of stress fiber assembly negative regulation of stress fiber assembly positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling positive regulation of mitochondrial depolarization positive regulation of substrate adhesion-dependent cell spreading uc007dgm.1 uc007dgm.2 uc007dgm.3 uc007dgm.4 
ENSMUST00000028024.5 Tnfsf4 ENSMUST00000028024.5 tumor necrosis factor (ligand) superfamily, member 4 (from RefSeq NM_009452.2) ENSMUST00000028024.1 ENSMUST00000028024.2 ENSMUST00000028024.3 ENSMUST00000028024.4 NM_009452 Ox40l P43488 TNFL4_MOUSE Txgp1l uc007dfn.1 uc007dfn.2 uc007dfn.3 uc007dfn.4 Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Homotrimer. P43488; P23510: TNFSF4; Xeno; NbExp=2; IntAct=EBI-519690, EBI-11724451; Membrane; Single-pass type II membrane protein. Belongs to the tumor necrosis factor family. blood vessel development cytokine production defense response to nematode acute inflammatory response positive regulation of immune effector process positive regulation of T cell cytokine production regulation of adaptive immune response positive regulation of type 2 immune response positive regulation of immunoglobulin mediated immune response cytokine activity tumor necrosis factor receptor binding protein binding extracellular space inflammatory response immune response signal transduction cholesterol metabolic process response to virus cell surface membrane integral component of membrane negative regulation of interferon-gamma production negative regulation of interleukin-17 production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-13 production positive regulation of interleukin-2 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production tumor necrosis factor receptor superfamily binding memory T cell activation T-helper 2 cell activation response to nitrogen dioxide cellular response to nitrogen dioxide CD4-positive, alpha-beta T cell costimulation T cell proliferation positive regulation of activated T cell proliferation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of memory T cell differentiation negative regulation of sequence-specific DNA binding transcription factor activity innate immune response negative regulation of regulatory T cell differentiation negative regulation of T-helper 1 cell differentiation positive regulation of T-helper 2 cell differentiation negative regulation of transcription, DNA-templated positive regulation of alpha-beta T cell proliferation negative regulation of cytokine secretion regulation of inflammatory response positive regulation of inflammatory response positive regulation of B cell activation positive regulation of immunoglobulin secretion negative regulation of T cell apoptotic process negative regulation of activation-induced cell death of T cells cellular response to lipopolysaccharide cellular response to prostaglandin E stimulus chemokine (C-C motif) ligand 11 production positive regulation of CD4-positive, alpha-beta T cell costimulation positive regulation of T cell migration positive regulation of T cell costimulation positive regulation of memory T cell activation positive regulation of T-helper 2 cell activation positive regulation of interleukin-4-dependent isotype switching to IgE isotypes negative regulation of extrinsic apoptotic signaling pathway uc007dfn.1 uc007dfn.2 uc007dfn.3 uc007dfn.4 
ENSMUST00000028045.4 Mrc1 ENSMUST00000028045.4 mannose receptor, C type 1 (from RefSeq NM_008625.2) ENSMUST00000028045.1 ENSMUST00000028045.2 ENSMUST00000028045.3 MRC1_MOUSE NM_008625 Q61830 Q8C502 uc008ikk.1 uc008ikk.2 uc008ikk.3 uc008ikk.4 Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. Q61830; P0DTC2: S; Xeno; NbExp=2; IntAct=EBI-642509, EBI-25474821; Endosome membrane ; Single-pass type I membrane protein Cell membrane ; Single- pass type I membrane protein Detected in macrophages. Down-regulated by interferon gamma. Name=Functional Glycomics Gateway - Glycan Binding; Note=Macrophage mannose receptor; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_181"; transmembrane signaling receptor activity mannose binding endosome plasma membrane endocytosis receptor-mediated endocytosis cell surface endosome membrane membrane integral component of membrane carbohydrate binding cargo receptor activity cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-4 uc008ikk.1 uc008ikk.2 uc008ikk.3 uc008ikk.4 
ENSMUST00000028049.13 Rabgap1l ENSMUST00000028049.13 RAB GTPase activating protein 1-like, transcript variant 1 (from RefSeq NM_013862.5) A6H6A9 ENSMUST00000028049.1 ENSMUST00000028049.10 ENSMUST00000028049.11 ENSMUST00000028049.12 ENSMUST00000028049.2 ENSMUST00000028049.3 ENSMUST00000028049.4 ENSMUST00000028049.5 ENSMUST00000028049.6 ENSMUST00000028049.7 ENSMUST00000028049.8 ENSMUST00000028049.9 Hhl Kiaa0471 NM_013862 Q3UH20 Q80TZ4 Q8BZD2 Q8BZP0 Q8CFI6 Q9QY69 RBG1L_MOUSE Rabgap1l uc007dej.1 uc007dej.2 uc007dej.3 uc007dej.4 GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (PubMed:27718357). Interacts (via Rab-GAP TBC domain) with ANK2 (via death domain). Early endosome Golgi apparatus Note=Colocalizes on endosomes partially with EEA1 (By similarity). Colocalizes and cotransports on motile vesicles with ANK2 (PubMed:27718357). Event=Alternative splicing; Named isoforms=4; Name=1 ; IsoId=A6H6A9-1; Sequence=Displayed; Name=2 ; IsoId=A6H6A9-2; Sequence=VSP_052927, VSP_052928, VSP_052929; Name=3 ; IsoId=A6H6A9-3; Sequence=VSP_052926, VSP_052930, VSP_052932; Name=4 ; IsoId=A6H6A9-4; Sequence=VSP_052925, VSP_052931; Expressed in embryonic heart and liver, and in hemopoietic cells (PubMed:10585558). Expressed in the corpus callosum in the central nervous system (CNS) and costameres in skeletal muscle at postnatal day (PND) 30 (PubMed:27718357). The arginine and glutamine fingers are critical for the GTPase- activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site. Sequence=AAF24092.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAF24092.1; Type=Frameshift; Evidence=; Sequence=AAF24092.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; GTPase activator activity nucleus endosome early endosome Golgi apparatus cilium intracellular protein transport endocytosis protein transport Rab GTPase binding regulation of protein localization megakaryocyte development activation of GTPase activity uc007dej.1 uc007dej.2 uc007dej.3 uc007dej.4 
ENSMUST00000028050.14 Stam ENSMUST00000028050.14 signal transducing adaptor molecule (SH3 domain and ITAM motif) 1, transcript variant 7 (from RefSeq NM_001421097.1) ENSMUST00000028050.1 ENSMUST00000028050.10 ENSMUST00000028050.11 ENSMUST00000028050.12 ENSMUST00000028050.13 ENSMUST00000028050.2 ENSMUST00000028050.3 ENSMUST00000028050.4 ENSMUST00000028050.5 ENSMUST00000028050.6 ENSMUST00000028050.7 ENSMUST00000028050.8 ENSMUST00000028050.9 NM_001421097 Q3UGN9 Q3UGN9_MOUSE Stam uc008ikg.1 uc008ikg.2 uc008ikg.3 Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the STAM family. cell intracellular protein transport uc008ikg.1 uc008ikg.2 uc008ikg.3 
ENSMUST00000028059.9 Rsu1 ENSMUST00000028059.9 Ras suppressor protein 1, transcript variant 1 (from RefSeq NM_009105.5) ENSMUST00000028059.1 ENSMUST00000028059.2 ENSMUST00000028059.3 ENSMUST00000028059.4 ENSMUST00000028059.5 ENSMUST00000028059.6 ENSMUST00000028059.7 ENSMUST00000028059.8 NM_009105 Q9D031 Q9D031_MOUSE Rsu1 uc008ijw.1 uc008ijw.2 uc008ijw.3 uc008ijw.4 focal adhesion positive regulation of cell-substrate adhesion positive regulation of GTPase activity uc008ijw.1 uc008ijw.2 uc008ijw.3 uc008ijw.4 
ENSMUST00000028061.10 4930562F07Rik ENSMUST00000028061.10 RIKEN cDNA 4930562F07 gene, transcript variant 1 (from RefSeq NR_038030.1) ENSMUST00000028061.1 ENSMUST00000028061.2 ENSMUST00000028061.3 ENSMUST00000028061.4 ENSMUST00000028061.5 ENSMUST00000028061.6 ENSMUST00000028061.7 ENSMUST00000028061.8 ENSMUST00000028061.9 NR_038030 uc007ded.1 uc007ded.2 uc007ded.3 uc007ded.4 uc007ded.1 uc007ded.2 uc007ded.3 uc007ded.4 
ENSMUST00000028062.8 Vim ENSMUST00000028062.8 vimentin (from RefSeq NM_011701.4) ENSMUST00000028062.1 ENSMUST00000028062.2 ENSMUST00000028062.3 ENSMUST00000028062.4 ENSMUST00000028062.5 ENSMUST00000028062.6 ENSMUST00000028062.7 NM_011701 Q5FWJ3 Q5FWJ3_MOUSE Vim uc008ikb.1 uc008ikb.2 uc008ikb.3 uc008ikb.4 Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Cell membrane Nucleus matrix Belongs to the intermediate filament family. double-stranded RNA binding structural constituent of cytoskeleton cytoplasm peroxisome cytosol polysome cytoskeleton intermediate filament cytoskeleton organization protein domain specific binding positive regulation of collagen biosynthetic process identical protein binding regulation of mRNA stability positive regulation of translation cellular response to lipopolysaccharide cellular response to muramyl dipeptide scaffold protein binding keratin filament binding ribonucleoprotein complex uc008ikb.1 uc008ikb.2 uc008ikb.3 uc008ikb.4 
ENSMUST00000028068.3 Ptf1a ENSMUST00000028068.3 pancreas specific transcription factor, 1a (from RefSeq NM_018809.2) ENSMUST00000028068.1 ENSMUST00000028068.2 NM_018809 PTF1A_MOUSE Ptf1p48 Q9QX98 Q9QYF5 Q9QYF6 uc012brh.1 uc012brh.2 Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. Component of the pancreas transcription factor 1 complex (PTF1) which is composed of TCF3/p75, TCF12/p64 and PTF1A/p48. TCF3 is responsible for the nuclear import of the p48/p64 complex. Interacts with TCF3 and RBPSUH/RBP-Jkappa. Nucleus. Cytoplasm. Note=In the cytoplasm loses its ability to form the PTF1 complex. Expressed in precursors of pancreatic islets, acini and ducts. Expressed at an early stage of pancreas development, shortly after the onset of endodermal budding that forms the pancreatic anlage. In 9.5 dpc embryo, expression is in the myelencephalon and the neural tube at the cervical level. In the 10.5 dpc embryo expression expands as a thin stripe to the posterior end of the neural tube. The central nervous system anterior to the myelencephalon is devoid of expression at this stage. In 12-12.5 dpc embryo, expression expands anteriorly to the cerebellum region. During retinogenesis, restricted to postmitotic neuronal precursor population in the ventricular zone of the developing retina. Not expressed before 12.5 dpc when is detected in the central region of the retina. By 14.5, expands from the center to the entire retina. Between 16.5 dpc and P1, continues to be expressed strongly in a subset of cells within the outer neuroblastic layer. Expression begins to be down-regulated by P2 and is undetectable in retinas from P6. Early postnatal lethal phenotype characterized by a lack of the exocrine pancreas, however, islet-like endocrine cell clusters are formed. A redirection of pancreatic precursors to intestinal fates is seen. At 16.5 dpc embryos show reduced size of cerebellar primordium and cerebellar aplasia. RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated multicellular organism development nervous system development tissue development retina layer formation cerebellum development cell differentiation hindbrain development pancreas development exocrine pancreas development endocrine pancreas development amacrine cell differentiation sequence-specific DNA binding cell fate commitment positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity retinoic acid receptor signaling pathway neuron fate commitment generation of neurons retina morphogenesis in camera-type eye regulation of neural retina development E-box binding uc012brh.1 uc012brh.2 
ENSMUST00000028071.13 Bmi1 ENSMUST00000028071.13 Bmi1 polycomb ring finger oncogene, transcript variant 1 (from RefSeq NM_007552.5) Bmi1 ENSMUST00000028071.1 ENSMUST00000028071.10 ENSMUST00000028071.11 ENSMUST00000028071.12 ENSMUST00000028071.2 ENSMUST00000028071.3 ENSMUST00000028071.4 ENSMUST00000028071.5 ENSMUST00000028071.6 ENSMUST00000028071.7 ENSMUST00000028071.8 ENSMUST00000028071.9 NM_007552 Pcgf4 Q2LC58 Q2LC58_MOUSE uc008ily.1 uc008ily.2 Nucleus cellular response to interleukin-1 cellular response to dexamethasone stimulus uc008ily.1 uc008ily.2 
ENSMUST00000028076.15 Mllt10 ENSMUST00000028076.15 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10, transcript variant 2 (from RefSeq NM_010804.4) AF10_MOUSE Af10 ENSMUST00000028076.1 ENSMUST00000028076.10 ENSMUST00000028076.11 ENSMUST00000028076.12 ENSMUST00000028076.13 ENSMUST00000028076.14 ENSMUST00000028076.2 ENSMUST00000028076.3 ENSMUST00000028076.4 ENSMUST00000028076.5 ENSMUST00000028076.6 ENSMUST00000028076.7 ENSMUST00000028076.8 ENSMUST00000028076.9 Mllt10 NM_010804 O54826 Q6NS43 uc008ilm.1 uc008ilm.2 uc008ilm.3 uc008ilm.4 Probably involved in transcriptional regulation. Binds to cruciform DNA (By similarity). In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (By similarity). Self-associates. Interacts with FSTL3; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with YEATS4. Interacts with SS18. Interacts with DOT1L (By similarity). Interacts with histone H3; interaction is necessary for MLLT10 binding to nucleosomes; interaction is inhibited by histone H3 'Lys-27' methylations (H3K27me1, H3K27me2 and H3K27me3) amd acetylation; interaction stabilizes association of MLLT10 at chromatin; interaction is essential for histone H3 'Lys-79' dimethylation (H3K79me2) (By similarity). O54826; Q02248: Ctnnb1; NbExp=2; IntAct=EBI-8459555, EBI-397872; O54826; Q60722: Tcf4; NbExp=3; IntAct=EBI-8459555, EBI-310070; Nucleus chromatin binding protein binding nucleus nucleoplasm cytosol nucleosome binding macromolecular complex histone binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc008ilm.1 uc008ilm.2 uc008ilm.3 uc008ilm.4 
ENSMUST00000028080.12 Nebl ENSMUST00000028080.12 nebulette, transcript variant 1 (from RefSeq NM_028757.3) ENSMUST00000028080.1 ENSMUST00000028080.10 ENSMUST00000028080.11 ENSMUST00000028080.2 ENSMUST00000028080.3 ENSMUST00000028080.4 ENSMUST00000028080.5 ENSMUST00000028080.6 ENSMUST00000028080.7 ENSMUST00000028080.8 ENSMUST00000028080.9 LNEBL_MOUSE Lnebl NM_028757 Q9DC07 uc008ila.1 uc008ila.2 uc008ila.3 Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion (By similarity). [Isoform 2]: Cytoplasm Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms exist.; Name=2; Synonyms=LIM-Nebulette, LIM-NBEL, LNBEL; IsoId=Q9DC07-1; Sequence=Displayed; Name=1; IsoId=Q0II04-1; Sequence=External; actin binding cytoplasm Z disc metal ion binding muscle fiber development actin filament binding cardiac muscle thin filament assembly uc008ila.1 uc008ila.2 uc008ila.3 
ENSMUST00000028081.13 Plxdc2 ENSMUST00000028081.13 plexin domain containing 2 (from RefSeq NM_026162.6) ENSMUST00000028081.1 ENSMUST00000028081.10 ENSMUST00000028081.11 ENSMUST00000028081.12 ENSMUST00000028081.2 ENSMUST00000028081.3 ENSMUST00000028081.4 ENSMUST00000028081.5 ENSMUST00000028081.6 ENSMUST00000028081.7 ENSMUST00000028081.8 ENSMUST00000028081.9 NM_026162 PXDC2_MOUSE Q6PET5 Q91ZV6 Q9DC11 Tem7r uc008ikz.1 uc008ikz.2 uc008ikz.3 May play a role in tumor angiogenesis. Interacts with CTTN. Membrane ; Single-pass type I membrane protein Expressed in tumor endothelium and in vessels of some normal tissues, such as the muscle and lung. Belongs to the plexin family. plasma membrane membrane integral component of membrane uc008ikz.1 uc008ikz.2 uc008ikz.3 
ENSMUST00000028083.6 Psmb7 ENSMUST00000028083.6 proteasome (prosome, macropain) subunit, beta type 7 (from RefSeq NM_011187.1) ENSMUST00000028083.1 ENSMUST00000028083.2 ENSMUST00000028083.3 ENSMUST00000028083.4 ENSMUST00000028083.5 Mmc14 NM_011187 O09084 P70195 PSB7_MOUSE Q542F7 Q9CZH4 Q9DCF7 uc008jnp.1 uc008jnp.2 uc008jnp.3 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity. Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; Evidence=; The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Cytoplasm Nucleus Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. Up-regulated by the antioxidant dithiolethione (D3T) in colon (at protein level). Belongs to the peptidase T1B family. proteasome complex endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteolysis peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, beta-subunit complex proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process uc008jnp.1 uc008jnp.2 uc008jnp.3 
ENSMUST00000028084.5 Nr5a1 ENSMUST00000028084.5 nuclear receptor subfamily 5, group A, member 1, transcript variant 2 (from RefSeq NM_139051.3) ENSMUST00000028084.1 ENSMUST00000028084.2 ENSMUST00000028084.3 ENSMUST00000028084.4 Ftzf1 NM_139051 P33242 Q812G5 STF1_MOUSE uc008jns.1 uc008jns.2 uc008jns.3 uc008jns.4 Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Binds DNA as a monomer (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with DGKQ and CDK7 (By similarity). Interacts with NR0B2, NCOA2 and PPARGC1A. Binds to and activated by HIPK3. Nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P33242-1; Sequence=Displayed; Name=2; IsoId=P33242-2; Sequence=VSP_003715; Expressed during early embryonic development. Expressed only in undifferentiated embryonal carcinoma cells. Acetylation stimulates the transcriptional activity. Sumoylation reduces CDK7-mediated phosphorylation on Ser-203. Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity (By similarity). Belongs to the nuclear hormone receptor family. NR5 subfamily. Sequence=BAA01441.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding luteinization DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding phospholipid binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter sex determination zinc ion binding lipid binding male gonad development female gonad development hormone-mediated signaling pathway tissue development multicellular organism aging positive regulation of gene expression enzyme binding reproductive process cell differentiation male sex determination adrenal gland development intracellular receptor signaling pathway hormone metabolic process steroid hormone mediated signaling pathway sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding maintenance of protein location in nucleus RNA polymerase II transcription factor complex response to gonadotropin-releasing hormone calcineurin-mediated signaling positive regulation of male gonad development negative regulation of female gonad development uc008jns.1 uc008jns.2 uc008jns.3 uc008jns.4 
ENSMUST00000028087.6 Ppp6c ENSMUST00000028087.6 protein phosphatase 6, catalytic subunit (from RefSeq NM_024209.3) A2ASL7 ENSMUST00000028087.1 ENSMUST00000028087.2 ENSMUST00000028087.3 ENSMUST00000028087.4 ENSMUST00000028087.5 NM_024209 PPP6_MOUSE Ppp6c Q9CQR6 uc008joi.1 uc008joi.2 uc008joi.3 Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:32474700). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (By similarity). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D13 During mitosis, regulates spindle positioning (By similarity). Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (By similarity). Acts as a regulator of innate immunity by mediating dephosphorylation CGAS, STING1 and RIGI (PubMed:32474700). Participates also in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation (By similarity). Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 (PubMed:32474700). CGAS dephosphorylation at 'Ser-420' impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain- containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with subunits PPP6R1, PPP6R2 and PPP6R3. Interacts with subunit ANKRD28. Interacts with IGBP1. Interacts with MAP3K7. Interacts with NFKBIE. Interacts with TRIM14 and WRNIP1; these interactions positively regulate the RIG-I signaling pathway. Mitochondrion Cytoplasm Ubiquitously expressed in all tissues tested with strongest expression in lung, spleen, liver, kidney and brain. Weaker expression observed in bladder, pancreas, heart and skeletal muscle. Embryonic lethality (PubMed:26868000). Embryos are apparently normal in blastocysts, but degenerate by E7.5 and display clear developmental defects at E8.5, suggesting that mutant embryos die after implantation (PubMed:26868000). Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily. immune system process phosphoprotein phosphatase activity protein serine/threonine phosphatase activity cytoplasm mitochondrion cytosol protein dephosphorylation cell cycle hydrolase activity innate immune response metal ion binding uc008joi.1 uc008joi.2 uc008joi.3 
ENSMUST00000028098.11 Orc4 ENSMUST00000028098.11 origin recognition complex, subunit 4, transcript variant 6 (from RefSeq NR_149356.2) ENSMUST00000028098.1 ENSMUST00000028098.10 ENSMUST00000028098.2 ENSMUST00000028098.3 ENSMUST00000028098.4 ENSMUST00000028098.5 ENSMUST00000028098.6 ENSMUST00000028098.7 ENSMUST00000028098.8 ENSMUST00000028098.9 NR_149356 O88708 ORC4_MOUSE Orc4l Q91V62 Q9QYX1 uc008jpp.1 uc008jpp.2 uc008jpp.3 uc008jpp.4 Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. DNA- binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Interacts with DBF4 (PubMed:12614612). Interacts with POLQ (By similarity). Nucleus. Belongs to the ORC4 family. nucleotide binding nuclear chromosome, telomeric region origin recognition complex DNA binding DNA replication origin binding ATP binding nucleus nuclear origin of replication recognition complex nucleolus cytosol DNA replication DNA replication initiation uc008jpp.1 uc008jpp.2 uc008jpp.3 uc008jpp.4 
ENSMUST00000028100.13 Epc1 ENSMUST00000028100.13 enhancer of polycomb homolog 1, transcript variant 2 (from RefSeq NM_027497.3) B2RRY2 ENSMUST00000028100.1 ENSMUST00000028100.10 ENSMUST00000028100.11 ENSMUST00000028100.12 ENSMUST00000028100.2 ENSMUST00000028100.3 ENSMUST00000028100.4 ENSMUST00000028100.5 ENSMUST00000028100.6 ENSMUST00000028100.7 ENSMUST00000028100.8 ENSMUST00000028100.9 EPC1_MOUSE Epc1 NM_027497 Q8C9X6 Q9Z299 uc008dzi.1 uc008dzi.2 uc008dzi.3 uc008dzi.4 Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:28694333). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (PubMed:28694333). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (By similarity). Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 (By similarity). KAT5/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4 (By similarity). Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41 (By similarity). Interacts with TRIM27 (By similarity). Interacts with MBTD1; interaction is direct and promotes recruitment of MBTD1 into the NuA4 histone acetyltransferase complex (By similarity). Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C9X6-1; Sequence=Displayed; Name=2; IsoId=Q8C9X6-2; Sequence=VSP_012878; Expressed in adult brain, heart, kidney, liver, lung, skeletal muscle and testis (PubMed:9735366). Expressed in male germ cells, present in round spermatids of steps 1 to 4 (PubMed:28694333). Mice are viable but display growth retardation, homeotic transformations of the axis and sterility in both males and females (PubMed:28694333). Male sterility is caused by defects in generation of elongating spermatids (PubMed:28694333). Belongs to the enhancer of polycomb family. negative regulation of transcription from RNA polymerase II promoter histone acetyltransferase activity nucleus nucleoplasm chromatin organization regulation of transcription from RNA polymerase II promoter nuclear membrane Piccolo NuA4 histone acetyltransferase complex NuA4 histone acetyltransferase complex vascular smooth muscle cell differentiation regulation of growth histone H4 acetylation histone H2A acetylation negative regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of striated muscle cell differentiation uc008dzi.1 uc008dzi.2 uc008dzi.3 uc008dzi.4 
ENSMUST00000028102.14 Kif5c ENSMUST00000028102.14 kinesin family member 5C (from RefSeq NM_008449.3) ENSMUST00000028102.1 ENSMUST00000028102.10 ENSMUST00000028102.11 ENSMUST00000028102.12 ENSMUST00000028102.13 ENSMUST00000028102.2 ENSMUST00000028102.3 ENSMUST00000028102.4 ENSMUST00000028102.5 ENSMUST00000028102.6 ENSMUST00000028102.7 ENSMUST00000028102.8 ENSMUST00000028102.9 KIF5C_MOUSE NM_008449 Nkhc2 P28738 Q6NXI9 Q9Z2F8 uc008jpy.1 uc008jpy.2 uc008jpy.3 Microtubule-associated force-producing protein that may play a role in organelle transport. Has ATPase activity (By similarity). Involved in synaptic transmission (By similarity). Mediates dendritic trafficking of mRNAs (PubMed:19608740). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Oligomer composed of two heavy chains and two light chains (PubMed:15286375). Interacts with GRIP1 (PubMed:11986669). Interacts with KLC3 and TRAK1 (By similarity). Interacts with ZFYVE27 (PubMed:21976701). P28738; Q9ESN9: Mapk8ip3; NbExp=8; IntAct=EBI-2506834, EBI-301496; Cytoplasm, cytoskeleton Cell projection, dendrite Note=Abundant in distal regions of dendrites. Composed of three structural domains: a large globular N- terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily. Sequence=CAA43677.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. The C-terminus (up to position 300) corresponds to KIF5C sequence.; Evidence=; nucleotide binding microtubule motor activity protein binding ATP binding cytoplasm cytoskeleton kinesin complex microtubule microtubule-based movement axon guidance microtubule binding motor neuron axon guidance ATP-dependent microtubule motor activity, plus-end-directed ATPase activity dendrite dendrite cytoplasm apolipoprotein receptor binding ciliary rootlet cell projection neuron projection neuronal cell body axonal growth cone ATP metabolic process synaptic vesicle transport mRNA transport dendritic transport of messenger ribonucleoprotein complex anterograde dendritic transport of messenger ribonucleoprotein complex anterograde dendritic transport of neurotransmitter receptor complex anterograde axonal protein transport axon cytoplasm uc008jpy.1 uc008jpy.2 uc008jpy.3 
ENSMUST00000028103.13 Lypd6b ENSMUST00000028103.13 LY6/PLAUR domain containing 6B, transcript variant 1 (from RefSeq NM_027990.4) A0JNT6 ENSMUST00000028103.1 ENSMUST00000028103.10 ENSMUST00000028103.11 ENSMUST00000028103.12 ENSMUST00000028103.2 ENSMUST00000028103.3 ENSMUST00000028103.4 ENSMUST00000028103.5 ENSMUST00000028103.6 ENSMUST00000028103.7 ENSMUST00000028103.8 ENSMUST00000028103.9 LPD6B_MOUSE NM_027990 Q9D7F2 uc008jpz.1 uc008jpz.2 uc008jpz.3 Likely acts as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-3(3):beta- 4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha- 3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence. However, according to another report in vitro it can weakly inhibits alpha-7 nAChRs. Cell membrane ; Lipid-anchor, GPI- anchor Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q9D7F2-2; Sequence=Displayed; Name=1; IsoId=Q9D7F2-1; Sequence=VSP_060613; cellular_component plasma membrane membrane acetylcholine receptor regulator activity anchored component of membrane regulation of neurotransmitter receptor activity uc008jpz.1 uc008jpz.2 uc008jpz.3 
ENSMUST00000028105.13 Mindy3 ENSMUST00000028105.13 MINDY lysine 48 deubiquitinase 3, transcript variant 10 (from RefSeq NR_149732.1) Carp ENSMUST00000028105.1 ENSMUST00000028105.10 ENSMUST00000028105.11 ENSMUST00000028105.12 ENSMUST00000028105.2 ENSMUST00000028105.3 ENSMUST00000028105.4 ENSMUST00000028105.5 ENSMUST00000028105.6 ENSMUST00000028105.7 ENSMUST00000028105.8 ENSMUST00000028105.9 Fam188a MINY3_MOUSE Mindy3 NR_149732 Q3UPS0 Q9CV28 Q9DCC9 uc008ijn.1 uc008ijn.2 uc008ijn.3 Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with COPS5. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CV28-1; Sequence=Displayed; Name=2; IsoId=Q9CV28-2; Sequence=VSP_031041; Belongs to the MINDY deubiquitinase family. FAM188 subfamily. nucleus nucleoplasm proteolysis apoptotic process peptidase activity cysteine-type peptidase activity hydrolase activity cysteine-type carboxypeptidase activity nuclear membrane thiol-dependent ubiquitinyl hydrolase activity protein K48-linked deubiquitination Lys48-specific deubiquitinase activity uc008ijn.1 uc008ijn.2 uc008ijn.3 
ENSMUST00000028106.11 Itga8 ENSMUST00000028106.11 integrin alpha 8, transcript variant 2 (from RefSeq NM_001408100.1) A2ARA8 ENSMUST00000028106.1 ENSMUST00000028106.10 ENSMUST00000028106.2 ENSMUST00000028106.3 ENSMUST00000028106.4 ENSMUST00000028106.5 ENSMUST00000028106.6 ENSMUST00000028106.7 ENSMUST00000028106.8 ENSMUST00000028106.9 ITA8_MOUSE NM_001408100 O70304 Q3UXV8 Q8BRG3 Q8C0H7 uc008ijk.1 uc008ijk.2 uc008ijk.3 Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-8 associates with beta-1. Membrane ; Single- pass type I membrane protein Cell membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2ARA8-1; Sequence=Displayed; Name=2; IsoId=A2ARA8-2; Sequence=VSP_027364, VSP_027365; In brain, expressed in deep cortex, hippocampal CA1, basolateral amygdala and striatum. In kidney, expressed in glomerular mesengium (at protein level). Expressed in mesenchymal cells of developing organs such as gut, lung, gonads and nephrogenic cord. Mice display renal agenesis and dysgenesis. This is associated with a reduced expression of Gdnf that is similarly found in mice lacking Npnt. Adult mice also display increased susceptibility to glomerular capillary destruction upon mechanical stress. Mice lacking Itga8 also have difficulty balancing associated with structural defects in the inner ear where utricular hair cells lack stereocilia. Belongs to the integrin alpha chain family. metanephros development kidney development endoplasmic reticulum plasma membrane cell adhesion cell-matrix adhesion integrin-mediated signaling pathway multicellular organism development nervous system development brain development memory integrin complex cell surface postsynaptic density membrane integral component of membrane cell projection organization cell differentiation extracellular matrix organization positive regulation of transforming growth factor beta receptor signaling pathway dendritic spine membrane substrate adhesion-dependent cell spreading inner ear morphogenesis perikaryon apical part of cell establishment of protein localization metal ion binding mesodermal cell differentiation smooth muscle tissue development positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation uc008ijk.1 uc008ijk.2 uc008ijk.3 
ENSMUST00000028111.6 Il2ra ENSMUST00000028111.6 interleukin 2 receptor, alpha chain (from RefSeq NM_008367.3) ENSMUST00000028111.1 ENSMUST00000028111.2 ENSMUST00000028111.3 ENSMUST00000028111.4 ENSMUST00000028111.5 Il2ra NM_008367 Q544I2 Q544I2_MOUSE uc008iiq.1 uc008iiq.2 uc008iiq.3 uc008iiq.4 Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. inflammatory response to antigenic stimulus regulation of T cell tolerance induction interleukin-2 receptor activity cell surface membrane integral component of membrane interleukin-2 binding interleukin-2-mediated signaling pathway positive regulation of T cell proliferation positive regulation of T cell differentiation negative regulation of defense response to virus negative regulation of immune response uc008iiq.1 uc008iiq.2 uc008iiq.3 uc008iiq.4 
ENSMUST00000028113.10 Potegl ENSMUST00000028113.10 POTE ankyrin domain family, member G like (from RefSeq NM_027635.1) 4931423N10Rik ENSMUST00000028113.1 ENSMUST00000028113.2 ENSMUST00000028113.3 ENSMUST00000028113.4 ENSMUST00000028113.5 ENSMUST00000028113.6 ENSMUST00000028113.7 ENSMUST00000028113.8 ENSMUST00000028113.9 Fem1al NM_027635 Potegl Q9D4J9 Q9D4J9_MOUSE uc008iof.1 uc008iof.2 uc008iof.3 molecular_function cellular_component biological_process uc008iof.1 uc008iof.2 uc008iof.3 
ENSMUST00000028117.4 Yme1l1 ENSMUST00000028117.4 YME1-like 1 (S. cerevisiae) (from RefSeq NM_013771.5) ENSMUST00000028117.1 ENSMUST00000028117.2 ENSMUST00000028117.3 NM_013771 O88967 Q7TNN5 YMEL1_MOUSE uc008ioe.1 uc008ioe.2 uc008ioe.3 uc008ioe.4 ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure (PubMed:17709429, PubMed:24616225, PubMed:26785494, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (By similarity). Required for normal, constitutive degradation of PRELID1 (PubMed:26785494). Catalyzes the degradation of OMA1 in response to membrane depolarization. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Homohexamer; may also form heterohexamers. Exists in several complexes of 600-1100 kDa. Interacts with AFG1L. Mitochondrion inner membrane Mitochondrion Detected in heart and skeletal muscle (at protein level). Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form. Complete embryonic lethality; embryos present a clear developmental delay at 8.5 dpc, and the hearts of mutant embryos fail to beat properly at 9.5 and 10.5 dpc. Cardiomyocyte-specific gene disruption gives rise to animals that develop dilated cardiomyopathy and myocardial fibrosis at about 20 weeks after birth; mutants have a median life span of about 46 weeks, much shorter than wild-type. Mitochondria from mutant cardiomyocytes are smaller than normal, but have normal cristae architecture and display no significant difference in the assembly of respiratory complexes. Keeping mice with a cardiomyocyte-specific gene disruption on a high-fat diet leads to weight gain and reduced glucose tolerance, and prevents the development of cardiomyopathy. Mice with Yme1l gene disruption in cardiomyocytes and skeletal muscle have a median life span of 125 weeks, similar to wild-type. Their heart function is normal, in spite of the presence of fragmented mitochondria due to the loss of Opa1 cleavage at position S2. Skeletal muscle mitochondrial dysfunction is known to be associated with impaired insulin signaling and glucose intolerance, and as expected, these mice display impaired glucose homeostasis with decreased fasting insulin levels in the blood serum and glucose intolerance. Mice with a double, cardiomyocyte-specific gene disruption of Yme1l and Oma1 have normal cardiac function and do not display myocardial fibrosis. Likewise, cardiomyocyte mitochondria have normal morphology. Mice with a skeletal muscle Yme1l gene disruption plus a double, cardiomyocyte-specific gene disruption of Yme1l and Oma1 display normal glucose tolerance. In the N-terminal section; belongs to the AAA ATPase family. In the C-terminal section; belongs to the peptidase M41 family. nucleotide binding ATP-dependent peptidase activity metalloendopeptidase activity ATP binding mitochondrion mitochondrial inner membrane proteolysis misfolded or incompletely synthesized protein catabolic process mitochondrion organization peptidase activity metallopeptidase activity cell proliferation membrane integral component of membrane nuclear body hydrolase activity protein hexamerization mitochondrial protein processing mitochondrial protein catabolic process negative regulation of apoptotic process metal ion binding uc008ioe.1 uc008ioe.2 uc008ioe.3 uc008ioe.4 
ENSMUST00000028118.9 Prkcq ENSMUST00000028118.9 protein kinase C, theta, transcript variant 1 (from RefSeq NM_008859.3) ENSMUST00000028118.1 ENSMUST00000028118.2 ENSMUST00000028118.3 ENSMUST00000028118.4 ENSMUST00000028118.5 ENSMUST00000028118.6 ENSMUST00000028118.7 ENSMUST00000028118.8 KPCT_MOUSE NM_008859 Pkcq Q02111 uc008iic.1 uc008iic.2 uc008iic.3 Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF- kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28- induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF- kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-538 (activation loop of the kinase domain), Ser-676 (turn motif) and Ser-695 (hydrophobic region), need to be phosphorylated for its full activation (By similarity). Part of a membrane raft complex composed at least of BCL10, CARD11, MALT1 and IKBKB (By similarity). Interacts with GLRX3 (via N- terminus) (By similarity). Interacts with ECT2 (By similarity). Interacts with CCDC88A/GIV; the interaction leads to phosphorylation of CCDC88A and inhibition of its guanine nucleotide exchange factor activity (By similarity). Q02111; Q99JP0: Map4k3; NbExp=2; IntAct=EBI-2639157, EBI-5324222; Q02111; P70257-2: Nfix; NbExp=3; IntAct=EBI-2639157, EBI-2639084; Q02111; Q8IVH8: MAP4K3; Xeno; NbExp=4; IntAct=EBI-2639157, EBI-1758170; Cytoplasm Cell membrane ; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse (By similarity). T-lymphocytes and skeletal muscle. The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain. Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PRKCQ upon antigen receptor ligation. Following TCR stimulation, phosphorylated at Tyr-90 and Ser-685 (By similarity). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. nucleotide binding immunological synapse immune system process protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding nucleus cytoplasm microtubule organizing center plasma membrane regulation of transcription, DNA-templated protein phosphorylation membrane protein ectodomain proteolysis inflammatory response regulation of G2/M transition of mitotic cell cycle membrane aggresome kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation neuromuscular junction positive regulation of telomere maintenance via telomerase positive regulation of interleukin-17 production positive regulation of interleukin-4 production intracellular signal transduction positive regulation of T cell proliferation positive regulation of protein import into nucleus sarcolemma positive regulation of interleukin-2 biosynthetic process negative regulation of insulin receptor signaling pathway metal ion binding positive regulation of protein secretion positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of filopodium assembly positive regulation of stress fiber assembly positive regulation of telomerase activity cell chemotaxis negative regulation of T cell apoptotic process regulation of platelet aggregation positive regulation of telomere capping positive regulation of T-helper 17 type immune response positive regulation of T-helper 2 cell activation uc008iic.1 uc008iic.2 uc008iic.3 
ENSMUST00000028119.7 Mastl ENSMUST00000028119.7 microtubule associated serine/threonine kinase-like (from RefSeq NM_025979.4) A2AQY2 ENSMUST00000028119.1 ENSMUST00000028119.2 ENSMUST00000028119.3 ENSMUST00000028119.4 ENSMUST00000028119.5 ENSMUST00000028119.6 GWL_MOUSE Gw Gwl NM_025979 Q3MIA9 Q5RJW0 Q6NXX9 Q8BVF3 Q8C0P0 Q9CZH9 Q9D9V0 uc008iob.1 uc008iob.2 uc008iob.3 uc008iob.4 Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser- 62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C0P0-1; Sequence=Displayed; Name=2; IsoId=Q8C0P0-2; Sequence=VSP_014576, VSP_014577; Phosphorylation at Thr-727 by CDK1 during M phase activates its kinase activity. Maximum phosphorylation occurs in prometaphase (By similarity). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Sequence=AAH86483.1; Type=Erroneous initiation; Evidence=; Sequence=BAB24595.1; Type=Erroneous initiation; Evidence=; Sequence=BAC37239.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; G2/M transition of mitotic cell cycle nucleotide binding mitotic cell cycle protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleoplasm cytoplasm centrosome microtubule organizing center cytoskeleton protein phosphorylation cellular response to DNA damage stimulus cell cycle female meiosis II kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation cleavage furrow negative regulation of phosphoprotein phosphatase activity intracellular signal transduction cell division protein phosphatase 2A binding regulation of cell cycle positive regulation of ubiquitin protein ligase activity uc008iob.1 uc008iob.2 uc008iob.3 uc008iob.4 
ENSMUST00000028123.4 Gad2 ENSMUST00000028123.4 glutamic acid decarboxylase 2 (from RefSeq NM_008078.2) ENSMUST00000028123.1 ENSMUST00000028123.2 ENSMUST00000028123.3 Gad2 NM_008078 Q548L4 Q548L4_MOUSE gad65 uc008ink.1 uc008ink.2 uc008ink.3 Catalyzes the production of GABA. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence= Homodimer. Cell membrane ; Lipid-anchor Cytoplasm, cytosol Cytoplasmic vesicle Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane ; Lipid-anchor Membrane ; Peripheral membrane protein ; Cytoplasmic side Presynaptic cell membrane ; Lipid-anchor Vesicle Belongs to the group II decarboxylase family. catalytic activity glutamate decarboxylase activity cytosol glutamate decarboxylation to succinate glutamate binding lyase activity carboxy-lyase activity carboxylic acid metabolic process pyridoxal phosphate binding synaptic vesicle membrane anchored component of membrane cytoplasmic vesicle response to drug protein heterodimerization activity perinuclear region of cytoplasm inhibitory synapse uc008ink.1 uc008ink.2 uc008ink.3 
ENSMUST00000028125.12 Zbtb43 ENSMUST00000028125.12 zinc finger and BTB domain containing 43, transcript variant 5 (from RefSeq NM_001355612.1) ENSMUST00000028125.1 ENSMUST00000028125.10 ENSMUST00000028125.11 ENSMUST00000028125.2 ENSMUST00000028125.3 ENSMUST00000028125.4 ENSMUST00000028125.5 ENSMUST00000028125.6 ENSMUST00000028125.7 ENSMUST00000028125.8 ENSMUST00000028125.9 Kiaa0414 NM_001355612 Q9DAI4 ZBT43_MOUSE Zfp297b Znf297b uc008jhw.1 uc008jhw.2 uc008jhw.3 May be involved in transcriptional regulation. Interacts with BDP1. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAB24254.2; Type=Erroneous initiation; Evidence=; Sequence=BAC65559.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding nucleus biological_process metal ion binding uc008jhw.1 uc008jhw.2 uc008jhw.3 
ENSMUST00000028129.13 Slc2a8 ENSMUST00000028129.13 solute carrier family 2, (facilitated glucose transporter), member 8, transcript variant 11 (from RefSeq NR_185316.1) ENSMUST00000028129.1 ENSMUST00000028129.10 ENSMUST00000028129.11 ENSMUST00000028129.12 ENSMUST00000028129.2 ENSMUST00000028129.3 ENSMUST00000028129.4 ENSMUST00000028129.5 ENSMUST00000028129.6 ENSMUST00000028129.7 ENSMUST00000028129.8 ENSMUST00000028129.9 Glut8 GlutX1 NR_185316 Q5BKP8 Q9JIF3 Q9JJP4 Q9JJZ0 SL2A8_MOUSE Slc2a8 uc008jhf.1 uc008jhf.2 uc008jhf.3 Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (PubMed:10821868, PubMed:10860996, PubMed:23396969). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1 (PubMed:27922102). Also able to mediate the transport of dehydroascorbate (PubMed:23396969). Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, ChEBI:CHEBI:4167; Evidence=; Reaction=D-fructose(out) = D-fructose(in); Xref=Rhea:RHEA:60372, ChEBI:CHEBI:37721; Evidence=; Reaction=L-dehydroascorbate(out) = L-dehydroascorbate(in); Xref=Rhea:RHEA:60380, ChEBI:CHEBI:58539; Evidence=; Reaction=alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out); Xref=Rhea:RHEA:17629, ChEBI:CHEBI:16551; Evidence=; Inhibited by cytochalasin B. Kinetic parameters: KM=2.33 mM for dehydroascorbate ; Interacts with AP2B1 (PubMed:16723738). Also able to mediate the transport of dehydroascorbate (PubMed:23396969). Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration. Highest level of expression in placenta and testis. Highly expressed in adult and pubertal testis, but not prepubertal testis. Lower levels of expression in brain, liver, heart, kidney, fat and skeletal muscle. High expression in blastocysts. Inhibited under glucose deprivation. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. response to hypoxia sugar:proton symporter activity fructose transmembrane transporter activity galactose transmembrane transporter activity glucose transmembrane transporter activity glucose binding plasma membrane integral component of plasma membrane glucose metabolic process male meiosis I synaptic vesicle insulin receptor signaling pathway carbohydrate transport fructose uniporter activity fructose transport galactose transport membrane integral component of membrane transmembrane transporter activity cytoplasmic vesicle membrane cytoplasmic vesicle dehydroascorbic acid transporter activity transmembrane transport dehydroascorbic acid transport hydrogen ion transmembrane transport glucose transmembrane transport uc008jhf.1 uc008jhf.2 uc008jhf.3 
ENSMUST00000028135.15 Niban2 ENSMUST00000028135.15 niban apoptosis regulator 2 (from RefSeq NM_146119.2) ENSMUST00000028135.1 ENSMUST00000028135.10 ENSMUST00000028135.11 ENSMUST00000028135.12 ENSMUST00000028135.13 ENSMUST00000028135.14 ENSMUST00000028135.2 ENSMUST00000028135.3 ENSMUST00000028135.4 ENSMUST00000028135.5 ENSMUST00000028135.6 ENSMUST00000028135.7 ENSMUST00000028135.8 ENSMUST00000028135.9 Fam129b NIBA2_MOUSE NM_146119 Niban2 Q3TCV6 Q3U8I3 Q3UC84 Q3UDW4 Q3UIE4 Q543S7 Q8BQ71 Q8CC78 Q8R1F1 uc008jhc.1 uc008jhc.2 uc008jhc.3 uc008jhc.4 May play a role in apoptosis suppression. Cytoplasm, cytosol Cell junction, adherens junction Membrane ; Lipid-anchor Note=In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase (By similarity). Phosphorylation may play a role in relocalization to the membrane (By similarity). As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases. Belongs to the Niban family. Sequence=BAC28456.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; transcription coactivator activity nucleoplasm cytoplasm cytosol plasma membrane adherens junction negative regulation of cell proliferation membrane cell junction gonadotropin secretion negative regulation of apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of DNA biosynthetic process positive regulation of transcription regulatory region DNA binding nucleus uc008jhc.1 uc008jhc.2 uc008jhc.3 uc008jhc.4 
ENSMUST00000028137.10 Coq4 ENSMUST00000028137.10 coenzyme Q4, transcript variant 1 (from RefSeq NM_178693.5) COQ4_MOUSE ENSMUST00000028137.1 ENSMUST00000028137.2 ENSMUST00000028137.3 ENSMUST00000028137.4 ENSMUST00000028137.5 ENSMUST00000028137.6 ENSMUST00000028137.7 ENSMUST00000028137.8 ENSMUST00000028137.9 NM_178693 Q8BGB8 uc008jac.1 uc008jac.2 uc008jac.3 Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. Cofactor biosynthesis; ubiquinone biosynthesis. Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Mitochondrion inner membrane eripheral membrane protein atrix side Belongs to the COQ4 family. molecular_function mitochondrion mitochondrial inner membrane ubiquinone biosynthetic process membrane extrinsic component of mitochondrial inner membrane macromolecular complex uc008jac.1 uc008jac.2 uc008jac.3 
ENSMUST00000028139.11 Med27 ENSMUST00000028139.11 mediator complex subunit 27, transcript variant 1 (from RefSeq NM_026896.5) A2AJV2 Crsp8 ENSMUST00000028139.1 ENSMUST00000028139.10 ENSMUST00000028139.2 ENSMUST00000028139.3 ENSMUST00000028139.4 ENSMUST00000028139.5 ENSMUST00000028139.6 ENSMUST00000028139.7 ENSMUST00000028139.8 ENSMUST00000028139.9 MED27_MOUSE NM_026896 Q78JI3 Q9D707 Q9DB40 uc008izs.1 uc008izs.2 uc008izs.3 uc008izs.4 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q9DB40-1; Sequence=Displayed; Name=2 ; IsoId=Q9DB40-2; Sequence=VSP_051870, VSP_051871; Belongs to the Mediator complex subunit 27 family. Sequence=AAH16537.1; Type=Erroneous initiation; Evidence=; ubiquitin ligase complex transcription coactivator activity nucleus nucleoplasm transcription factor complex nucleolus cytosol regulation of transcription from RNA polymerase II promoter protein ubiquitination mediator complex stem cell population maintenance ubiquitin protein ligase activity positive regulation of nucleic acid-templated transcription uc008izs.1 uc008izs.2 uc008izs.3 uc008izs.4 
ENSMUST00000028148.11 Fpgs ENSMUST00000028148.11 folylpolyglutamyl synthetase, transcript variant 6 (from RefSeq NR_185133.1) A2AK69 ENSMUST00000028148.1 ENSMUST00000028148.10 ENSMUST00000028148.2 ENSMUST00000028148.3 ENSMUST00000028148.4 ENSMUST00000028148.5 ENSMUST00000028148.6 ENSMUST00000028148.7 ENSMUST00000028148.8 ENSMUST00000028148.9 FOLC_MOUSE NR_185133 P48760 Q3U0B4 Q99K38 uc008jgm.1 uc008jgm.2 uc008jgm.3 uc008jgm.4 Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Dihydrofolate, tetrahydrofolate, 5,10- methylenetetrahydrofolate, 10-formyltetrahydrofolate and 5- formyltetrahydrofolate are the best substrates. Folic acid and 5- methyltetrahydrofolate can also act as substrates. Reaction=(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L- glutamate = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:10580, Rhea:RHEA-COMP:14738, Rhea:RHEA-COMP:14740, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:141005, ChEBI:CHEBI:456216; EC=6.3.2.17; Evidence= Name=a monovalent cation; Xref=ChEBI:CHEBI:60242; Evidence=; Note=A monovalent cation. ; Inhibited by ammonium sulfate. Inhibited by pentaglutamate derivative of DDATHF, but isoform 2 is inhibited to a greater extent at lower concentrations of the compound that is isoform 5. Isoform 5 is virtually unaffected by H(4)PteGlu(5) and 5,10-CH(2)- H(4)PteGlu(5) at concentrations that substantially inhibits the activity of isoform 2. Isoform 2 and 5 are equally sensitive to polyglutamates of 10-CHO-H(4)-PteGlu. Kinetic parameters: KM=17.7 uM for aminopterin (isoform 5 at 34 degrees Celsius and pH 8.9) ; KM=15.4 uM for aminopterin (isoform 2 at 34 degrees Celsius and pH 8.9) ; KM=7.6 uM for (6R)-DDATHF (isoform 5 at 34 degrees Celsius and pH 8.9) ; KM=1.2 uM for (6R)-DDATHF (isoform 2 at 34 degrees Celsius and pH 8.9) ; KM=6.3 uM for (6S)-H(4)PteGlu (isoform 5 at 34 degrees Celsius and pH 8.9) ; KM=1.4 uM for (6S)-H(4)PteGlu (isoform 2 at 34 degrees Celsius and pH 8.9) ; KM=2.9 uM for (6R)-10-CHO-H(4)PteGlu (isoform 5 at 34 degrees Celsius and pH 8.9) KM=2.0 uM for (6R)-10-CHO-H(4)PteGlu (isoform 2 at 34 degrees Celsius and pH 8.9) KM=64 uM for (6S)-5-CH(3)-H(4)PteGlu (isoform 5 at 34 degrees Celsius and pH 8.9) KM=54 uM for (6S)-5-CH(3)-H(4)PteGlu (isoform 2 at 34 degrees Celsius and pH 8.9) KM=122 uM for (6S)-5-CHO-H(4)PteGlu (isoform 5 at 34 degrees Celsius and pH 8.9) KM=75 uM for (6S)-5-CHO-H(4)PteGlu (isoform 2 at 34 degrees Celsius and pH 8.9) pH dependence: Optimum pH is 8.2-9.5 using 500 uM folic acid (PteGlu) and 25 uM dl- 5-formyltetrahydrofolate (dl-5-CHO-H(4)PteGlu) as substrates. ; Temperature dependence: Optimum temperature is 37 degrees Celsius. Activity completely lost within a few hours at 4 degrees Celsius in the absence of ATP and glycerol. ; Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis. Monomer. [Isoform 1]: Mitochondrion inner membrane Mitochondrion matrix [Isoform 2]: Cytoplasm Event=Alternative promoter usage, Alternative splicing, Alternative initiation; Named isoforms=5; Name=1; Synonyms=Mitochondrial; IsoId=P48760-1; Sequence=Displayed; Name=2; Synonyms=Cytoplasmic; IsoId=P48760-2; Sequence=VSP_018734; Name=3; IsoId=P48760-3; Sequence=VSP_041961; Name=4; IsoId=P48760-4; Sequence=VSP_041962; Name=5; IsoId=P48760-5; Sequence=VSP_041967; With non-specific probe, highest content in kidney and liver and lowest in spleen, lung and small intestine, and readily detectable in all of the tumors except hepatoma. Isoform 1 and isoform 2 expressed in leukemic cells and isoform 4 and isoform 5 in liver cells. Isoform 1 and isoform 2 exclusively expressed in hepatoma and Lewis lung carcinoma. Isoform 1 and isoform 2 also expressed in bone marrow, small intestine and spleen. Kidney expresses isoform 1, isoform 2, isoform 4 and isoform 5. [Isoform 2]: Produced by alternative initiation at Met- 43 of isoform 1. [Isoform 3]: Produced by alternative splicing of isoform 1. [Isoform 4]: Produced by alternative promoter usage. [Isoform 5]: Produced by alternative initiation at Met- 24 of isoform 4. Belongs to the folylpolyglutamate synthase family. Sequence=AAH05484.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding tetrahydrofolylpolyglutamate synthase activity ATP binding cytoplasm mitochondrion mitochondrial inner membrane mitochondrial matrix cytosol glutamate metabolic process one-carbon metabolic process folic acid-containing compound metabolic process cell proliferation biosynthetic process folic acid-containing compound biosynthetic process membrane ligase activity metal ion binding tetrahydrofolylpolyglutamate biosynthetic process uc008jgm.1 uc008jgm.2 uc008jgm.3 uc008jgm.4 
ENSMUST00000028151.7 Dpm2 ENSMUST00000028151.7 dolichyl-phosphate mannosyltransferase subunit 2, regulatory (from RefSeq NM_010073.2) DPM2_MOUSE Dpm2 ENSMUST00000028151.1 ENSMUST00000028151.2 ENSMUST00000028151.3 ENSMUST00000028151.4 ENSMUST00000028151.5 ENSMUST00000028151.6 NM_010073 Q9Z324 uc008jfu.1 uc008jfu.2 uc008jfu.3 Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. Part of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the GPI-GNT complex. Protein modification; protein glycosylation. Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. Component of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts with PIGA, PIGC and PIGQ. Endoplasmic reticulum membrane; Multi-pass membrane protein. Belongs to the DPM2 family. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex dolichyl-phosphate beta-D-mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation GPI anchor biosynthetic process membrane integral component of membrane dolichol metabolic process integral component of endoplasmic reticulum membrane enzyme regulator activity regulation of protein stability dolichol-phosphate-mannose synthase complex perinuclear region of cytoplasm regulation of catalytic activity mannosylation uc008jfu.1 uc008jfu.2 uc008jfu.3 
ENSMUST00000028155.12 Tsc1 ENSMUST00000028155.12 TSC complex subunit 1, transcript variant 2 (from RefSeq NM_022887.5) A2AHW1 ENSMUST00000028155.1 ENSMUST00000028155.10 ENSMUST00000028155.11 ENSMUST00000028155.2 ENSMUST00000028155.3 ENSMUST00000028155.4 ENSMUST00000028155.5 ENSMUST00000028155.6 ENSMUST00000028155.7 ENSMUST00000028155.8 ENSMUST00000028155.9 Kiaa0243 NM_022887 Q3UHF2 Q7TS92 Q80U55 Q924U7 Q9EP53 TSC1_MOUSE Tsc1 uc008iyz.1 uc008iyz.2 uc008iyz.3 uc008iyz.4 Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12820960). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12820960). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12820960). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (By similarity). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (By similarity). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (PubMed:16707451). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (By similarity). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (By similarity). Component of the TSC-TBC complex (also named Rhebulator complex), composed of 2 molecules of TSC1, 2 molecules of TSC2 and 1 molecule of TBC1D7 (By similarity). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (By similarity). Forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (By similarity). Forms a complex containing HSP90AA1, TSC1 and TSC2; TSC1 is required to recruit TCS2 to the complex (By similarity). Interacts (via C-terminus) with the closed form of HSP90AA1 (via the middle domain and TPR repeat-binding motif) (PubMed:29127155). Interacts with DOCK7 (By similarity). Interacts with FBXW5. Interacts with WDR45B. Interacts with RPAP3 and URI1 (By similarity). Q9EP53; D3YZU1: Shank1; NbExp=2; IntAct=EBI-1202690, EBI-2314988; Q9EP53; Q61037: Tsc2; NbExp=6; IntAct=EBI-1202690, EBI-7924402; Lysosome membrane ; Peripheral membrane protein Cytoplasm, cytosol Note=Recruited to lysosomal membranes in a RHEB-dependent process in absence of nutrients. In response to nutrients, the complex dissociates from lysosomal membranes and relocalizes to the cytosol. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9EP53-1; Sequence=Displayed; Name=2; IsoId=Q9EP53-2; Sequence=VSP_037747; Name=3; IsoId=Q9EP53-3; Sequence=VSP_037747, VSP_037748; Name=4; IsoId=Q9EP53-4; Sequence=VSP_037747, VSP_037749; The C-terminal putative coiled-coil domain is necessary for interaction with TSC2. Phosphorylation at Ser-502 does not affect interaction with TSC2. Conditional knockout in glia causes an increase in HSP90AA1 ATPase activity and a down-regulation of ULK1, ERBB2, ESR1 and NR3C1 protein levels in the brain. kidney development neural tube closure regulation of cell-matrix adhesion adaptive immune response protein binding nucleus cytoplasm lipid particle cytosol cytoskeleton actin filament cell cortex rRNA export from nucleus regulation of translation potassium ion transport cell-matrix adhesion nervous system development negative regulation of cell proliferation adult locomotory behavior negative regulation of neuron projection development postsynaptic density membrane positive regulation of macroautophagy negative regulation of macroautophagy negative regulation of translation hippocampus development cerebral cortex development lamellipodium cell projection organization growth cone Hsp70 protein binding negative regulation of TOR signaling negative regulation of ATPase activity GTPase activating protein binding response to insulin macromolecular complex TSC1-TSC2 complex negative regulation of GTPase activity ATPase inhibitor activity myelination cell projection intracellular membrane-bounded organelle memory T cell differentiation regulation of phosphoprotein phosphatase activity negative regulation of cell size regulation of protein kinase activity glucose import negative regulation of insulin receptor signaling pathway protein N-terminus binding perinuclear region of cytoplasm synapse organization protein stabilization chaperone binding protein heterooligomerization regulation of stress fiber assembly positive regulation of stress fiber assembly regulation of cell cycle Hsp90 protein binding regulation of focal adhesion assembly positive regulation of focal adhesion assembly cardiac muscle cell differentiation activation of GTPase activity cellular response to oxygen-glucose deprivation regulation of neuron death negative regulation of oxidative stress-induced neuron death uc008iyz.1 uc008iyz.2 uc008iyz.3 uc008iyz.4 
ENSMUST00000028156.8 Gfi1b ENSMUST00000028156.8 growth factor independent 1B, transcript variant 1 (from RefSeq NM_008114.3) ENSMUST00000028156.1 ENSMUST00000028156.2 ENSMUST00000028156.3 ENSMUST00000028156.4 ENSMUST00000028156.5 ENSMUST00000028156.6 ENSMUST00000028156.7 GFI1B_MOUSE NM_008114 O70237 Q3U039 uc008iyu.1 uc008iyu.2 uc008iyu.3 uc008iyu.4 Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. Interacts with histone methyltransferases EHMT2 and SUV39H1. Interacts with ARIH2 (via RING-type 2) and with RUNX1T1 (By similarity). Forms a complex with GATA1. Component of a RCOR-GFI-KDM1A- HDAC complex. Interacts directly with RCOR1, KDM1A and HDAC2. O70237; Q9Z148: Ehmt2; NbExp=2; IntAct=EBI-4287943, EBI-444966; O70237; O54864: Suv39h1; NbExp=2; IntAct=EBI-4287943, EBI-302230; Nucleus Note=Localized at foci of pericentric heterochromatin. Expressed in bone marrow and in spleen. Detected in hematopoietic stem cells, erythroblasts, and megakaryocytes. Expressed in thymocytes. Down-regulated by IL6 treatment in myelomonocytic cells, and in response to EPO in myeloid cells; EPO-induced down-regulation of Gfi1b is STAT5-dependent. The zinc finger domain is essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain. The SNAG domain of GFIs is required for nuclear location and for interaction with some corepressors. Methylation at Lys-8 in the SNAG domain seems required for the recruitment of the corepressor complex. Mice are not viable and embryos die by 15 dpc during the transition from primitive to definitive hematopoiesis. They exhibit delayed maturation of primitive erythrocytes and subsequently die with failure to produce enucleated erythrocytes. Their fetal liver contains erythroid and megakaryocytic precursor arrested in their development. Transgenic mice with insertion of green fluorescence protein (GFP) cDNA in Gfi1b gene allowed to show up-regulation of Gfi1b in early stage of B-cell and in a subset of early thymic pre-T-cell. Mice overexpressing Gfi1b display peripheral T-lymphopenia and a profound defect in activation after CD3 cross-linking. Spleen cells show reduction in the numbers of CD4 and CD8 T-cells. Thymocyte lineage commitment and maturation are altered. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding nucleic acid binding DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated multicellular organism development nuclear matrix positive regulation of granulocyte differentiation regulation of erythrocyte differentiation metal ion binding negative regulation of histone H3-K4 methylation positive regulation of histone H3-K9 methylation uc008iyu.1 uc008iyu.2 uc008iyu.3 uc008iyu.4 
ENSMUST00000028161.6 Cel ENSMUST00000028161.6 carboxyl ester lipase (from RefSeq NM_009885.2) CEL_MOUSE ENSMUST00000028161.1 ENSMUST00000028161.2 ENSMUST00000028161.3 ENSMUST00000028161.4 ENSMUST00000028161.5 Lip1 NM_009885 Q64285 uc008iyr.1 uc008iyr.2 uc008iyr.3 uc008iyr.4 uc008iyr.5 Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs) (PubMed:27509211). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (PubMed:27509211). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12045; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + di-(9Z)-octadecenoylglycerol + H(+); Xref=Rhea:RHEA:38575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38576; Evidence=; Reaction=1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + H(+) + octanoate; Xref=Rhea:RHEA:47864, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:76978, ChEBI:CHEBI:88066; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47865; Evidence=; Reaction=a sterol ester + H2O = a fatty acid + a sterol + H(+); Xref=Rhea:RHEA:10100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15889, ChEBI:CHEBI:28868, ChEBI:CHEBI:35915; EC=3.1.1.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10101; Evidence=; Reaction=an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+); Xref=Rhea:RHEA:12957, ChEBI:CHEBI:2571, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:47622; EC=3.1.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12958; Evidence=; Reaction=a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+); Xref=Rhea:RHEA:47348, ChEBI:CHEBI:2571, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:50477; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47349; Evidence=; Reaction=9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy- octadecanoate + H(+) + hexadecanoate; Xref=Rhea:RHEA:52052, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:83670, ChEBI:CHEBI:136286; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52053; Evidence=; Reaction=9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)- octadecenoate + 9-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52048, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:136282, ChEBI:CHEBI:136286; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52049; Evidence=; Reaction=cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+); Xref=Rhea:RHEA:33875, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30823, ChEBI:CHEBI:46898; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33876; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=12-hexadecanoyloxy-octadecanoate + H2O = 12- hydroxyoctadecanoate + H(+) + hexadecanoate; Xref=Rhea:RHEA:52056, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:83677, ChEBI:CHEBI:84201; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52057; Evidence=; Reaction=12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)- octadecenoate + 12-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:52060, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:84201, ChEBI:CHEBI:136302; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52061; Evidence=; Reaction=13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)- octadecenoate + 13-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:136303, ChEBI:CHEBI:136304; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52065; Evidence=; Reaction=9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 9-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52068, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:136286, ChEBI:CHEBI:136309; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52069; Evidence=; Reaction=12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 12-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:52072, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:84201, ChEBI:CHEBI:136312; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52073; Evidence=; Reaction=13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 13-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52076, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:136304, ChEBI:CHEBI:136315; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52077; Evidence=; Reaction=12-octadecanoyloxy-octadecanoate + H2O = 12- hydroxyoctadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:84201, ChEBI:CHEBI:136330; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52081; Evidence=; Reaction=13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy- octadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52084, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:136304, ChEBI:CHEBI:136335; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52085; Evidence=; Reaction=5-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 5-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52092, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:136369, ChEBI:CHEBI:136370; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52093; Evidence=; Reaction=9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy- octadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52096, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:136286, ChEBI:CHEBI:136373; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52097; Evidence=; Activated by bile salts such as sodium taurocholate. Interacts with CLC. Secreted EXpressed by eosinophils. Belongs to the type-B carboxylesterase/lipase family. lysophospholipase activity sterol esterase activity triglyceride lipase activity extracellular region extracellular space cytoplasm rough endoplasmic reticulum Golgi apparatus cytosol integral component of plasma membrane lipid metabolic process cholesterol catabolic process neuron cell-cell adhesion acetylesterase activity cell surface lipid catabolic process hydrolase activity hydrolase activity, acting on ester bonds pancreatic juice secretion macromolecular complex signaling receptor activity neurexin family protein binding retinol metabolic process zymogen granule glycosphingolipid binding intracellular membrane-bounded organelle macromolecular complex binding membrane raft synapse ceramide catabolic process synaptic vesicle endocytosis retinyl-palmitate esterase activity modulation of synaptic transmission carboxylic ester hydrolase activity postsynaptic membrane assembly presynaptic membrane assembly presynapse uc008iyr.1 uc008iyr.2 uc008iyr.3 uc008iyr.4 uc008iyr.5 
ENSMUST00000028162.5 Ptges2 ENSMUST00000028162.5 prostaglandin E synthase 2 (from RefSeq NM_133783.2) A2ASQ2 ENSMUST00000028162.1 ENSMUST00000028162.2 ENSMUST00000028162.3 ENSMUST00000028162.4 Gbf1 NM_133783 PGES2_MOUSE Pges2 Q8BWM0 Q99J30 uc008jfm.1 uc008jfm.2 uc008jfm.3 uc008jfm.4 The protein encoded by this gene is a Golgi membrane-associated prostaglandin E synthase candidate, which is capable of catalyzing the conversion of prostaglandin H2 to prostaglandin E2 in vitro. However, a study using mice deficient of this gene suggests that this enzyme does not contribute to prostaglandin E2 biosynthesis in vivo. This protein is synthesized as a Golgi membrane-bound protein, but its N-terminal hydrophobic region is cleaved off during protein maturation to produce the predominant soluble truncated form that still retains the enzyme activity. This soluble protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE), possibly via an interaction with CAAAT/enhancer-binding protein-beta. [provided by RefSeq, Oct 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC004846.1, AK050616.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate (By similarity). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy- 5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity). May also have transactivation activity toward IFN- gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear (PubMed:12050152). Reaction=prostaglandin H2 = prostaglandin E2; Xref=Rhea:RHEA:12893, ChEBI:CHEBI:57405, ChEBI:CHEBI:606564; EC=5.3.99.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12894; Evidence=; Reaction=prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)- heptadecatrienoate + malonaldehyde; Xref=Rhea:RHEA:48644, ChEBI:CHEBI:57405, ChEBI:CHEBI:90694, ChEBI:CHEBI:566274; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48645; Evidence=; Isomerase activity is increased by sulfhydril compounds. Dithiothreitol (DTT) is most effective, followed by glutathione (GSH) and 2-mercaptoethanol. Lipid metabolism; prostaglandin biosynthesis. Homodimer. Interacts with EXOSC10 (By similarity). May interact with CEBPB. Golgi apparatus membrane ; Single-pass membrane protein Nucleus Note=According to PubMed:12050152, some fraction may be nuclear. [Prostaglandin E synthase 2 truncated form]: Cytoplasm Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. Widely expressed. Expressed in brain, heart, liver, colon and lung. Constitutively expressed. Not induced during tissue inflammation. Down-regulated in the absence of PTGES. Synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme. Deficient mice displays no obvious phenotype and are fertile. Loss of PTGES2 expression does not result in a measurable decrease in PGE2 levels in any tissue or cell type examined from healthy mice (PubMed:19010439). Injection of the diabetogenic agent streptozotocin (STZ) at a dose to induce type-1 diabetes to knockout (KO) mice aggravates STZ-induced liver toxicity associated with high lethality, despite similar glucose levels (PubMed:25076362). Belongs to the GST superfamily. It is not known if heme and GST are required for prostaglandin synthase activity. The protein copurifies with heme and GST when DTT is omitted during the purification procedure. The GSH-heme complex-bound enzyme has been proposed to act as a lyase and catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)- heptadecatrienoic acid (HHT) and malondialdehyde (MDA). Boiling the enzyme leads to loss of prostaglandin synthase activity, but does not eliminate the lyase activity. Besides, free heme can catalyze the formation of 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT) (By similarity). A more recent study demonstrates the GSH-dependent property of PTGES2, DTT dissociates the bound heme to produce active PGE2 synthase in vitro (By similarity). PTGES2 can only catalyzes PGE2 synthesis in the free state as an enzyme, while in vivo it forms a complex with heme and does not participate in PGE2 synthesis (By similarity). In agreement with this study, the in vivo evidence from PTGES2 deficient mice do not show that this protein is responsible for the PGE2 production under basal or pathophysiological conditions (PubMed:19010439). Golgi membrane prostaglandin biosynthetic process DNA binding nucleus cytoplasm mitochondrion Golgi apparatus cytosol lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process electron carrier activity protein disulfide oxidoreductase activity membrane integral component of membrane lyase activity isomerase activity heme binding electron transport chain glutathione binding cell redox homeostasis positive regulation of transcription, DNA-templated secretion prostaglandin-E synthase activity oxidation-reduction process uc008jfm.1 uc008jfm.2 uc008jfm.3 uc008jfm.4 
ENSMUST00000028175.7 Cytip ENSMUST00000028175.7 cytohesin 1 interacting protein (from RefSeq NM_139200.4) A2AS77 CYTIP_MOUSE ENSMUST00000028175.1 ENSMUST00000028175.2 ENSMUST00000028175.3 ENSMUST00000028175.4 ENSMUST00000028175.5 ENSMUST00000028175.6 NM_139200 Pscdbp Q3TZH1 Q8R4T4 Q91VY6 Q9QZA9 uc008jsi.1 uc008jsi.2 uc008jsi.3 By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm. Interacts with CYTH1 and SNX27. Cytoplasm Early endosome Note=Recruited from the cytosol to endosomes by SNX27. nucleoplasm cytoplasm endosome early endosome cytosol cell cortex regulation of cell adhesion uc008jsi.1 uc008jsi.2 uc008jsi.3 
ENSMUST00000028177.11 Olfm1 ENSMUST00000028177.11 olfactomedin 1, transcript variant 1 (from RefSeq NM_019498.2) ENSMUST00000028177.1 ENSMUST00000028177.10 ENSMUST00000028177.2 ENSMUST00000028177.3 ENSMUST00000028177.4 ENSMUST00000028177.5 ENSMUST00000028177.6 ENSMUST00000028177.7 ENSMUST00000028177.8 ENSMUST00000028177.9 NM_019498 Olfm1 Q8R357 Q8R357_MOUSE uc008iyd.1 uc008iyd.2 uc008iyd.3 Secreted Synapse atrioventricular valve formation nervous system development positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of apoptotic process cardiac epithelial to mesenchymal transition uc008iyd.1 uc008iyd.2 uc008iyd.3 
ENSMUST00000028178.14 Acvr1c ENSMUST00000028178.14 activin A receptor, type IC, transcript variant 1 (from RefSeq NM_001111030.1) A2AJR4 ACV1C_MOUSE Acvr1c Alk7 ENSMUST00000028178.1 ENSMUST00000028178.10 ENSMUST00000028178.11 ENSMUST00000028178.12 ENSMUST00000028178.13 ENSMUST00000028178.2 ENSMUST00000028178.3 ENSMUST00000028178.4 ENSMUST00000028178.5 ENSMUST00000028178.6 ENSMUST00000028178.7 ENSMUST00000028178.8 ENSMUST00000028178.9 NM_001111030 Q8K348 uc008jsp.1 uc008jsp.2 uc008jsp.3 uc008jsp.4 Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA- COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Binds the type 2 receptor protein ACVR2A. Membrane ; Single-pass type I membrane protein Expressed in interdigital regions in developing limb buds. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Sequence=AK142396; Type=Frameshift; Evidence=; nucleotide binding trophectodermal cell proliferation response to dietary excess protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I ATP binding cytoplasm plasma membrane integral component of plasma membrane protein phosphorylation apoptotic process transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor complex assembly pattern specification process response to glucose cell surface membrane integral component of membrane kinase activity phosphorylation activin receptor activity, type I transferase activity growth factor binding lipid storage cell differentiation apoptotic nuclear changes response to insulin activin receptor signaling pathway nodal signaling pathway nodal binding regulation of apoptotic process positive regulation of apoptotic process receptor complex positive regulation of cysteine-type endopeptidase activity involved in apoptotic process SMAD binding negative regulation of insulin secretion metal ion binding activin receptor complex activin binding BMP receptor binding negative regulation of trophoblast cell migration negative regulation of chorionic trophoblast cell proliferation in utero embryonic development determination of left/right symmetry uc008jsp.1 uc008jsp.2 uc008jsp.3 uc008jsp.4 
ENSMUST00000028179.15 Fcnb ENSMUST00000028179.15 ficolin B (from RefSeq NM_010190.1) ENSMUST00000028179.1 ENSMUST00000028179.10 ENSMUST00000028179.11 ENSMUST00000028179.12 ENSMUST00000028179.13 ENSMUST00000028179.14 ENSMUST00000028179.2 ENSMUST00000028179.3 ENSMUST00000028179.4 ENSMUST00000028179.5 ENSMUST00000028179.6 ENSMUST00000028179.7 ENSMUST00000028179.8 ENSMUST00000028179.9 FCN2_MOUSE Fcn2 NM_010190 O70497 Q3KNL6 uc008ixv.1 uc008ixv.2 uc008ixv.3 May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity). Homotrimer. Interacts with elastin. Interacts with MASP1 and MASP2. Secreted. The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding. Belongs to the ficolin lectin family. G-protein coupled receptor binding complement activation, lectin pathway immune system process cell surface pattern recognition receptor signaling pathway extracellular region collagen trimer G-protein coupled receptor signaling pathway signaling pattern recognition receptor activity carbohydrate binding extrinsic component of external side of plasma membrane sialic acid binding protein localization to cell surface recognition of apoptotic cell innate immune response negative regulation of viral entry into host cell metal ion binding carbohydrate derivative binding positive regulation of interleukin-8 secretion uc008ixv.1 uc008ixv.2 uc008ixv.3 
ENSMUST00000028187.7 Lamc3 ENSMUST00000028187.7 laminin gamma 3 (from RefSeq NM_011836.4) ENSMUST00000028187.1 ENSMUST00000028187.2 ENSMUST00000028187.3 ENSMUST00000028187.4 ENSMUST00000028187.5 ENSMUST00000028187.6 LAMC3_MOUSE NM_011836 Q4VAI3 Q9R0B6 Q9WTW6 uc008jef.1 uc008jef.2 uc008jef.3 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-3 is a subunit of laminin-12 (laminin-213), laminin-14 (laminin-423) and laminin-15 (laminin-523). Secreted, extracellular space, extracellular matrix, basement membrane. Strongly expressed in capillaries and arterioles of kidney as well as in interstitial Leydig cells of testis. The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. Domain IV is globular. cell morphogenesis involved in differentiation extracellular region basement membrane cell adhesion visual perception animal organ morphogenesis tissue development astrocyte development cell migration substrate adhesion-dependent cell spreading retina development in camera-type eye uc008jef.1 uc008jef.2 uc008jef.3 
ENSMUST00000028188.8 Fibcd1 ENSMUST00000028188.8 fibrinogen C domain containing 1 (from RefSeq NM_178887.4) A2AV25 ENSMUST00000028188.1 ENSMUST00000028188.2 ENSMUST00000028188.3 ENSMUST00000028188.4 ENSMUST00000028188.5 ENSMUST00000028188.6 ENSMUST00000028188.7 FBCD1_MOUSE NM_178887 Q6P9R8 Q8BJE7 Q8BL54 uc008jee.1 uc008jee.2 uc008jee.3 Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non- acetylated counterparts. Can facilitate the endocytosis of acetylated components (By similarity). Homotetramer; disulfide-linked. Membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AV25-1; Sequence=Displayed; Name=2; IsoId=A2AV25-2; Sequence=VSP_026621; chitin binding membrane integral component of membrane metal ion binding uc008jee.1 uc008jee.2 uc008jee.3 
ENSMUST00000028199.12 Tor1b ENSMUST00000028199.12 torsin family 1, member B (from RefSeq NM_133673.3) ENSMUST00000028199.1 ENSMUST00000028199.10 ENSMUST00000028199.11 ENSMUST00000028199.2 ENSMUST00000028199.3 ENSMUST00000028199.4 ENSMUST00000028199.5 ENSMUST00000028199.6 ENSMUST00000028199.7 ENSMUST00000028199.8 ENSMUST00000028199.9 NM_133673 Q8VEI4 Q9ER41 TOR1B_MOUSE uc008jda.1 uc008jda.2 uc008jda.3 May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non- neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Homohexamer. Interacts with TOR1A; the interaction may be specific of neural tissues. Interacts with TOR1AIP1; TOR1AIP1 is required for TOR1B location on the nuclear membrane. Interacts (ATP- bound) with TOR1AIP2; important for endoplasmic reticulum integrity. Endoplasmic reticulum lumen. Nucleus membrane. Highly expressed in liver and muscle; lower expression levels are observed in brain (at protein level). At 16 dpc and 18 dpc, widely expressed with higher expression levels in non-neural cells and hippocampus (at protein level). N-glycosylated. Belongs to the ClpA/ClpB family. Torsin subfamily. nucleotide binding protein binding ATP binding nucleus nuclear envelope cytoplasm endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum organization membrane hydrolase activity ATPase activity kinesin binding nuclear membrane protein localization to nucleus identical protein binding chaperone mediated protein folding requiring cofactor nuclear membrane organization uc008jda.1 uc008jda.2 uc008jda.3 
ENSMUST00000028200.9 Tor1a ENSMUST00000028200.9 torsin family 1, member A (torsin A) (from RefSeq NM_144884.2) Dyt1 ENSMUST00000028200.1 ENSMUST00000028200.2 ENSMUST00000028200.3 ENSMUST00000028200.4 ENSMUST00000028200.5 ENSMUST00000028200.6 ENSMUST00000028200.7 ENSMUST00000028200.8 NM_144884 Q9ER39 TOR1A_MOUSE uc008jdc.1 uc008jdc.2 uc008jdc.3 uc008jdc.4 Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non- neural tissues. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Homohexamer. Interacts with TOR1B; the interaction may be specific of neural tissues. Interacts (ATP-bound) with TOR1AIP1 and TOR1AIP2; the interactions induce ATPase activity. Interacts with KLHL14; preferentially when ATP-free. Interacts with KLC1 (via TPR repeats); the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with COPS4; the interaction associates TOR1A with the CSN complex. Interacts with SNAPIN; the interaction is direct and associates SNAPIN with the CSN complex. Interacts with STON2. Interacts (ATP-bound) with SYNE3 (via KASH domain); the interaction is required for SYNE3 nuclear envelope localization. Interacts with VIM; the interaction associates TOR1A with the cytoskeleton. Interacts with PLEC. Interacts (ATP-bound) with SLC6A3; regulates SLC6A3 transport to the plasma membrane. Endoplasmic reticulum lumen Nucleus membrane; Peripheral membrane protein. Cell projection, growth cone. Cytoplasmic vesicle membrane Synapse, synaptosome Cytoplasm, cytoskeleton Cytoplasmic vesicle, secretory vesicle Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Note=Upon oxidative stress, redistributes to protusions from the cell surface (By similarity). Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus membrane is mediated by the interaction with TOR1AIP2. Widely expressed (at protein level). At 16 dpc and 18 dpc, widely expressed with higher expression levels in neural tissues. In the spinal cord, expressed as early as 12 dpc until P21, the expression levels decrease in the adulthood (at protein level). N-glycosylated. Animals fail to feed or vocalize and die within 48 hours of birth. At 18 dpc, the global structure of the central nervous system is normal. However, at the cellular level, nuclear envelope abnormalities, with membranous vesicle-appearing structures in the perinuclear space, are observed in multiple areas of the central nervous system, including neurons of the spinal cord, pons, frontal cortex, and hippocampus. Belongs to the ClpA/ClpB family. Torsin subfamily. nucleotide binding protein deneddylation protein binding ATP binding nucleus nuclear envelope cytoplasm endoplasmic reticulum endoplasmic reticulum lumen cytoskeleton response to oxidative stress organelle organization nuclear envelope organization cell adhesion synaptic vesicle cytoskeletal protein binding membrane hydrolase activity ATPase activity kinesin binding cell junction transport vesicle secretory granule growth cone cytoplasmic vesicle membrane neuron projection development cytoplasmic vesicle nuclear membrane protein localization to nucleus extrinsic component of endoplasmic reticulum membrane identical protein binding cell projection neuron projection intracellular membrane-bounded organelle wound healing, spreading of cells intermediate filament cytoskeleton organization synapse synaptic vesicle transport unfolded protein binding chaperone mediated protein folding requiring cofactor regulation of dopamine uptake involved in synaptic transmission misfolded protein binding chaperone-mediated protein folding ER-associated misfolded protein catabolic process nuclear membrane organization chaperone-mediated protein transport positive regulation of synaptic vesicle endocytosis regulation of protein localization to cell surface uc008jdc.1 uc008jdc.2 uc008jdc.3 uc008jdc.4 
ENSMUST00000028205.10 BC005624 ENSMUST00000028205.10 cDNA sequence BC005624 (from RefSeq NM_144885.3) ENSMUST00000028205.1 ENSMUST00000028205.2 ENSMUST00000028205.3 ENSMUST00000028205.4 ENSMUST00000028205.5 ENSMUST00000028205.6 ENSMUST00000028205.7 ENSMUST00000028205.8 ENSMUST00000028205.9 NM_144885 Q3TQI7 Q99JW3 TLS1_MOUSE uc008jdd.1 uc008jdd.2 uc008jdd.3 uc008jdd.4 Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (By similarity). May also modulate exon inclusion events (By similarity). PPlays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (By similarity). Binds U5 snRNA (By similarity). Required for proper chromosome segregation (By similarity). Not required for splicing of shelterin components (By similarity). Component of the spliceosome (By similarity). Interacts with SNRNP200; the interaction is direct (By similarity). Interacts with PRPF8 (By similarity). Nucleus Chromosome, centromere Note=Dispersed throughout the nucleus during interphase (By similarity). Colocalizes with microtubule attachment sites at centromeres following mitotic checkpoint activation (By similarity). Belongs to the TLS1 family. molecular_function nucleus nucleoplasm spliceosomal complex cytosol regulation of mRNA splicing, via spliceosome uc008jdd.1 uc008jdd.2 uc008jdd.3 uc008jdd.4 
ENSMUST00000028209.15 Dolpp1 ENSMUST00000028209.15 dolichyl pyrophosphate phosphatase 1, transcript variant 1 (from RefSeq NM_020329.5) DOPP1_MOUSE ENSMUST00000028209.1 ENSMUST00000028209.10 ENSMUST00000028209.11 ENSMUST00000028209.12 ENSMUST00000028209.13 ENSMUST00000028209.14 ENSMUST00000028209.2 ENSMUST00000028209.3 ENSMUST00000028209.4 ENSMUST00000028209.5 ENSMUST00000028209.6 ENSMUST00000028209.7 ENSMUST00000028209.8 ENSMUST00000028209.9 NM_020329 Q8BN02 Q8R0P7 Q9CRF2 Q9JMF7 uc008jci.1 uc008jci.2 uc008jci.3 Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. Reaction=a dolichyl diphosphate + H2O = a dolichyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:14385, Rhea:RHEA-COMP:9517, Rhea:RHEA- COMP:9529, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57497, ChEBI:CHEBI:57683; EC=3.6.1.43; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Multi-pass membrane protein Widely expressed with highest levels in brain, kidney, lung and intestine. Belongs to the dolichyldiphosphatase family. endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation protein N-linked glycosylation lipid biosynthetic process membrane integral component of membrane hydrolase activity integral component of endoplasmic reticulum membrane dolichyldiphosphatase activity uc008jci.1 uc008jci.2 uc008jci.3 
ENSMUST00000028220.10 Fbxw2 ENSMUST00000028220.10 F-box and WD-40 domain protein 2, transcript variant 16 (from RefSeq NM_001406273.1) ENSMUST00000028220.1 ENSMUST00000028220.2 ENSMUST00000028220.3 ENSMUST00000028220.4 ENSMUST00000028220.5 ENSMUST00000028220.6 ENSMUST00000028220.7 ENSMUST00000028220.8 ENSMUST00000028220.9 Fbxw2 Fwd2 NM_001406273 Q9QUH1 Q9QUH1_MOUSE uc289vka.1 uc289vka.2 uc289vka.1 uc289vka.2 
ENSMUST00000028222.13 Hspa5 ENSMUST00000028222.13 Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:12411443, PubMed:12475965). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (PubMed:12411443). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (By similarity). (from UniProt P20029) AK160821 BIP_MOUSE ENSMUST00000028222.1 ENSMUST00000028222.10 ENSMUST00000028222.11 ENSMUST00000028222.12 ENSMUST00000028222.2 ENSMUST00000028222.3 ENSMUST00000028222.4 ENSMUST00000028222.5 ENSMUST00000028222.6 ENSMUST00000028222.7 ENSMUST00000028222.8 ENSMUST00000028222.9 Grp78 Hspa5 O35642 P20029 Q3UFF2 Q61630 uc008jis.1 uc008jis.2 uc008jis.3 uc008jis.4 Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:12411443, PubMed:12475965). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (PubMed:12411443). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.10; Evidence=; The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate- binding (SBD) domains (By similarity). In the ADP-bound and nucleotide- free (apo) states, the two domains have little interaction (By similarity). In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates (By similarity). J domain-containing co-chaperones (DNAJB9/ERdj4 or DNAJC10/ERdj5) stimulate the ATPase activity and are required for efficient substrate recognition by HSPA5/BiP. Homooligomerization inactivates participating HSPA5/BiP protomers and probably act as reservoirs to store HSPA5/BiP molecules when they are not needed by the cell (By similarity). Monomer and homooligomer; homooligomerization via the interdomain linker inactivates the chaperone activity and acts as a storage of HSPA5/BiP molecules (By similarity). Interacts with DNAJC1 (via J domain) (PubMed:12065409). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (PubMed:16931514). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (PubMed:12475965). Interacts with TMEM132A and TRIM21 (By similarity). May form a complex with ERLEC1, OS9, SEL1L and SYVN1 (By similarity). Interacts with DNAJC10 (PubMed:12411443). Interacts with DNAJB9/ERdj4; leading to recruit HSPA5/BiP to ERN1/IRE1 (PubMed:11836248). Interacts with ERN1/IRE1; interaction takes place following interaction with DNAJB9/ERdj4 and leads to inactivate ERN1/IRE1 (By similarity). Interacts with MX1 (PubMed:21992152). Interacts with METTL23 (By similarity). Interacts with CEMIP; the interaction induces calcium leakage from the endoplasmic reticulum and cell migration (By similarity). Interacts with PCSK4 form; the interaction takes place in the endoplasmic reticulum (By similarity). Interacts with CIPC (By similarity). Interacts with CCDC88B (via C- terminus); the interaction opposes ERN1-mediated JNK activation, protecting against apoptosis (By similarity). Interacts with INPP5K; necessary for INPP5K localization at the endoplasmic reticulum (By similarity). Interacts with MANF; the interaction is direct (By similarity). Interacts with LOXL2; leading to activate the ERN1/IRE1- XBP1 pathway of the unfolded protein response (By similarity). Interacts with CLU under stressed condition; interaction increases CLU protein stability; facilitates its retrotranslocation and redistribution to the mitochondria; cooperatively suppress stress- induced apoptosis by stabilizing mitochondrial membrane integrity (By similarity). Interacts with CCDC47 (PubMed:25009997). Interacts with CLN3 (By similarity). Interacts with KIAA1324; may regulate the function of HSPA5 in apoptosis and cell proliferation. Interacts with CASP7 (By similarity). Interacts with ILDR2; the interaction stabilizes ILDR2 expression (PubMed:33863978). Interacts with ADAM7 (PubMed:20945367). P20029; O35451: Atf6b; NbExp=2; IntAct=EBI-772325, EBI-8361741; P20029; Q99KV1: Dnajb11; NbExp=4; IntAct=EBI-772325, EBI-8328260; P20029; O75460: ERN1; Xeno; NbExp=2; IntAct=EBI-772325, EBI-371750; P20029; P00441: SOD1; Xeno; NbExp=7; IntAct=EBI-772325, EBI-990792; Endoplasmic reticulum lumen lanosome Cytoplasm Cell surface. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). Localizes to the cell surface in epithelial cells; high levels of free iron promotes cell surface localization (By similarity). Expressed in sperm (at protein level). Induced in sinus, lung and brain tissue in response to 3- hydroxybutyric acid (BHB)-induced acidosis (PubMed:27159390). Induced in sinus, lung and brain tissue following intraperitoneal injection of streptozotocin to produce a mouse model of diabetic ketoacidosis (DKA) (PubMed:20484814). The interdomain linker regulates the chaperone activity by mediating the formation of homooligomers. Homooligomers are formed by engagement of the interdomain linker of one HSPA5/BiP molecule as a typical substrate of an adjacent HSPA5/BiP molecule. HSPA5/BiP oligomerization inactivates participating HSPA5/BiP protomers. HSPA5/BiP oligomers probably act as reservoirs to store HSPA5/BiP molecules when they are not needed by the cell. When the levels of unfolded proteins rise, cells can rapidly break up these oligomers to make active monomers. In unstressed cells, AMPylation at Thr-519 by FICD inactivates the chaperome activity: AMPylated form is locked in a relatively inert state and only weakly stimulated by J domain-containing proteins. In response to endoplasmic reticulum stress, de-AMPylation by the same protein, FICD, restores the chaperone activity. Belongs to the heat shock protein 70 family. nucleotide binding luteolysis protein binding ATP binding extracellular region nucleus cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane smooth endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment cytosol plasma membrane ER overload response response to unfolded protein COP9 signalosome response to radiation cell surface positive regulation of neuron projection development membrane hydrolase activity ATPase activity enzyme binding protein domain specific binding cerebellum structural organization cerebellar Purkinje cell layer development integral component of endoplasmic reticulum membrane neuron differentiation positive regulation of cell migration ER-associated ubiquitin-dependent protein catabolic process midbody negative regulation of transforming growth factor beta receptor signaling pathway endoplasmic reticulum unfolded protein response heat shock protein binding posttranslational protein targeting to membrane, translocation positive regulation of protein ubiquitination ubiquitin protein ligase binding macromolecular complex cellular response to heat cellular response to unfolded protein endoplasmic reticulum chaperone complex response to endoplasmic reticulum stress maintenance of protein localization in endoplasmic reticulum cellular response to drug positive regulation of embryonic development protein refolding cellular response to glucose starvation response to cocaine ATPase activity, coupled ribosome binding negative regulation of apoptotic process myelin sheath intracellular membrane-bounded organelle protein binding involved in protein folding unfolded protein binding chaperone mediated protein folding requiring cofactor neuron apoptotic process proteolysis involved in cellular protein catabolic process misfolded protein binding cellular response to antibiotic cellular response to calcium ion cellular response to manganese ion cellular response to cAMP cellular response to interleukin-4 cellular response to gamma radiation negative regulation of protein homodimerization activity stress response to metal ion toxin transport negative regulation of IRE1-mediated unfolded protein response response to methamphetamine hydrochloride cellular response to nerve growth factor stimulus uc008jis.1 uc008jis.2 uc008jis.3 uc008jis.4 
ENSMUST00000028225.12 Psmd5 ENSMUST00000028225.12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5, transcript variant 1 (from RefSeq NM_080554.2) A2AUB0 ENSMUST00000028225.1 ENSMUST00000028225.10 ENSMUST00000028225.11 ENSMUST00000028225.2 ENSMUST00000028225.3 ENSMUST00000028225.4 ENSMUST00000028225.5 ENSMUST00000028225.6 ENSMUST00000028225.7 ENSMUST00000028225.8 ENSMUST00000028225.9 Kiaa0072 NM_080554 PSMD5_MOUSE Q3UFV2 Q5DU49 Q8BJY1 Q8BMA9 Q8VEE9 uc008jje.1 uc008jje.2 uc008jje.3 Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity). Interacts with PSMC1, PSMC2, PSMD1 and PSMD6. Part of transient complex containing PSMD5, PSMC2, PSMC1 and PSMD2 formed during the assembly of the 26S proteasome. Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins. Belongs to the proteasome subunit S5B/HSM3 family. proteasome regulatory particle, base subcomplex proteasome accessory complex proteasome assembly proteasome regulatory particle assembly uc008jje.1 uc008jje.2 uc008jje.3 
ENSMUST00000028232.7 Phf19 ENSMUST00000028232.7 PHD finger protein 19, transcript variant 5 (from RefSeq NR_184813.1) ENSMUST00000028232.1 ENSMUST00000028232.2 ENSMUST00000028232.3 ENSMUST00000028232.4 ENSMUST00000028232.5 ENSMUST00000028232.6 NR_184813 PHF19_MOUSE Pcl3 Q9CXG9 uc008jjh.1 uc008jjh.2 uc008jjh.3 Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23104054, PubMed:23160351, PubMed:22438827, PubMed:23273982). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self- renewal (PubMed:22438827). Also binds histone H3 dimethylated at 'Lys- 36' (H3K36me2) (By similarity). Associates with the PRC2 complex, which consists of the core components EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:23160351, PubMed:22438827). Forms a dimeric PRC2.1 (class 1, PRC-PCL) complex consisting of at least SUZ12, RBBP4, and PHF19 or MTF2; PHF19 and MTF2 stabilize the dimeric structure which enhances PRC2 interaction with chromatin. Interacts with SUZ12; competes with AEBP2 for SUZ12 binding. Interacts with EZH2 (via its Tudor domain). Interacts with RIOX1 (By similarity). Nucleus Note=Localizes to chromatin as part of the PRC2 complex. The Tudor domain recognizes and binds H3K36me3. Belongs to the Polycomblike family. negative regulation of transcription from RNA polymerase II promoter transcription factor activity, sequence-specific DNA binding nucleus chromatin organization stem cell population maintenance methylated histone binding sequence-specific DNA binding positive regulation of transcription, DNA-templated metal ion binding stem cell differentiation positive regulation of histone H3-K27 methylation ESC/E(Z) complex nucleosome binding uc008jjh.1 uc008jjh.2 uc008jjh.3 
ENSMUST00000028233.7 Hc ENSMUST00000028233.7 hemolytic complement (from RefSeq NM_010406.3) A2AS36 C5 CO5_MOUSE ENSMUST00000028233.1 ENSMUST00000028233.2 ENSMUST00000028233.3 ENSMUST00000028233.4 ENSMUST00000028233.5 ENSMUST00000028233.6 NM_010406 P06684 uc289vlf.1 uc289vlf.2 This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M35525.1, M35526.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. [C5a anaphylatoxin]: Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). [C5a anaphylatoxin]: Interacts with C5AR1. Secreted. Note=Murine C5 deficiency is caused by a 2 base-pairs deletion resulting in frameshift and premature truncation. All C5-deficient strains contain this mutation. in utero embryonic development immune system process endopeptidase inhibitor activity extracellular region membrane attack complex extracellular space inflammatory response complement activation, alternative pathway complement activation, classical pathway positive regulation of vascular endothelial growth factor production negative regulation of macrophage chemotaxis negative regulation of endopeptidase activity cytolysis innate immune response positive regulation of angiogenesis positive regulation of chemokine secretion uc289vlf.1 uc289vlf.2 
ENSMUST00000028238.15 Rab14 ENSMUST00000028238.15 RAB14, member RAS oncogene family (from RefSeq NM_026697.4) ENSMUST00000028238.1 ENSMUST00000028238.10 ENSMUST00000028238.11 ENSMUST00000028238.12 ENSMUST00000028238.13 ENSMUST00000028238.14 ENSMUST00000028238.2 ENSMUST00000028238.3 ENSMUST00000028238.4 ENSMUST00000028238.5 ENSMUST00000028238.6 ENSMUST00000028238.7 ENSMUST00000028238.8 ENSMUST00000028238.9 NM_026697 Q91V41 RAB14_MOUSE uc008jjz.1 uc008jjz.2 Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Interacts with ZFYVE20 (By similarity). Interacts with KIF16B. Recycling endosome Early endosome membrane ; Lipid-anchor ; Cytoplasmic side Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side Golgi apparatus, trans-Golgi network membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasmic vesicle, phagosome Note=Recruited to recycling endosomes by DENND6A. Recruited to phagosomes containing S.aureus or M.tuberculosis. Belongs to the small GTPase superfamily. Rab family. Golgi membrane nucleotide binding GTPase activity protein binding GTP binding lysosome endosome early endosome late endosome rough endoplasmic reticulum Golgi apparatus Golgi stack trans-Golgi network cytosol plasma membrane intracellular protein transport Golgi to endosome transport body fluid secretion fibroblast growth factor receptor signaling pathway protein transport membrane apical plasma membrane GDP binding transport vesicle trans-Golgi network transport vesicle cytoplasmic vesicle membrane cytoplasmic vesicle myosin V binding early endosome membrane endocytic recycling Rab protein signal transduction regulation of protein localization nuclear outer membrane-endoplasmic reticulum membrane network defense response to bacterium intracellular membrane-bounded organelle apical protein localization phagocytic vesicle regulation of embryonic development perinuclear region of cytoplasm recycling endosome phagosome maturation phagolysosome assembly involved in apoptotic cell clearance alveolar lamellar body anchored component of synaptic vesicle membrane uc008jjz.1 uc008jjz.2 
ENSMUST00000028241.7 Stom ENSMUST00000028241.7 stomatin (from RefSeq NM_013515.2) ENSMUST00000028241.1 ENSMUST00000028241.2 ENSMUST00000028241.3 ENSMUST00000028241.4 ENSMUST00000028241.5 ENSMUST00000028241.6 Epb7.2 Epb72 NM_013515 O88988 P54116 Q3UP81 Q60744 Q62455 STOM_MOUSE Stom uc008jkh.1 uc008jkh.2 uc008jkh.3 Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. Interacts with LANCL1 (By similarity). Interacts with SLC2A1 (By similarity). Interacts with SLC4A1; this interaction positively regulates SLC4A1 activity (By similarity). Identified in large complexes with SLC40A1, SLC14A1, SLC29A1 and AQP1 (By similarity). Homodimer and higher order homooligomers (By similarity). The homodimer is banana-shaped (By similarity). Interacts with ASIC1, ASIC2 and ASIC3 (PubMed:15471860, PubMed:22850675). Interacts with STOML1; may redistribute STOM from the plasma membrane to late endosomes (By similarity). P54116; P54116: Stom; NbExp=5; IntAct=EBI-8004826, EBI-8004826; P54116; O35240: Asic3; Xeno; NbExp=3; IntAct=EBI-8004826, EBI-982374; Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Cell membrane ; Lipid-anchor ; Cytoplasmic side Membrane raft Melanosome Cytoplasmic vesicle Note=Localizes to juxtanuclear structure probably derived from the Golgi apparatus. Colocalizes with cortical actin microfilaments at small plasma membrane protrusions. Associates with alpha-granular lipid rafts. Translocates from the alpha-granular lipid rafts to the cell membrane on thrombin activation and selectively enriched in released microvesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Expressed in all sensory neurons of the dorsal root ganglia. In the CNS, expressed in many neurons of the spinal cord, medulla and pons. Expressed only in scattered neurons in the cortex, hippocampus, thalamus and basal ganglia. In the cerebellum, expressed in all Purkinje cells (at protein level). Widely expressed with high levels in heart, liver, skeletal muscle and testis and low levels in lung, brain and spleen. First expressed in the developing embryo at 11.5 dpc when target innervation is complete. Expression continues into adulthood. Belongs to the band 7/mec-2 family. Sequence=AAB18857.1; Type=Erroneous gene model prediction; Evidence=; protein binding cytoplasm mitochondrion endoplasmic reticulum cytoskeleton plasma membrane integral component of plasma membrane membrane cytoplasmic vesicle regulation of ion transmembrane transport melanosome identical protein binding protein homodimerization activity positive regulation by host of viral genome replication membrane raft perinuclear region of cytoplasm positive regulation of viral process protein homooligomerization RNA polymerase binding positive regulation of protein targeting to membrane regulation of acid-sensing ion channel activity uc008jkh.1 uc008jkh.2 uc008jkh.3 
ENSMUST00000028243.2 4930568D16Rik ENSMUST00000028243.2 RIKEN cDNA 4930568D16 gene (from RefSeq NM_029463.2) A2AUQ7 ENSMUST00000028243.1 GTA1L_MOUSE Ggta1l1 NM_029463 Q9D4R9 uc012bum.1 uc012bum.2 Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)- beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:13013, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:133507, ChEBI:CHEBI:138024; EC=2.4.1.87; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mn(2+) ion per subunit. ; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Note=Membrane-bound form in trans cisternae of Golgi. The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity). This gene is not expressed in humans. Belongs to the glycosyltransferase 6 family. Golgi apparatus carbohydrate metabolic process protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups lipid glycosylation vesicle Golgi cisterna membrane metal ion binding N-acetyllactosaminide 3-alpha-galactosyltransferase activity uc012bum.1 uc012bum.2 
ENSMUST00000028248.11 Ttll11 ENSMUST00000028248.11 tubulin tyrosine ligase-like family, member 11 (from RefSeq NM_029774.3) A4Q9F4 ENSMUST00000028248.1 ENSMUST00000028248.10 ENSMUST00000028248.2 ENSMUST00000028248.3 ENSMUST00000028248.4 ENSMUST00000028248.5 ENSMUST00000028248.6 ENSMUST00000028248.7 ENSMUST00000028248.8 ENSMUST00000028248.9 NM_029774 Q1LZJ9 Q9D4E7 TTL11_MOUSE Ttll11 uc008jkz.1 uc008jkz.2 uc008jkz.3 uc008jkz.4 uc008jkz.5 Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:17499049, PubMed:20530212). Preferentially mediates ATP-dependent polyglutamate long side-chain elongation over the initiation step of the polyglutamylation reaction (PubMed:17499049, PubMed:20530212). Preferentially modifies the alpha-tubulin tail over a beta-tail (PubMed:17499049). Required for CCSAP localization to both spindle and cilia microtubules (By similarity). Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions (PubMed:20530212). Reaction=ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L- glutamyl-L-glutamyl-[protein] + H(+) + phosphate; Xref=Rhea:RHEA:60144, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15517, ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143622, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60145; Evidence=; Reaction=(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60148, Rhea:RHEA-COMP:15519, Rhea:RHEA-COMP:15675, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143623, ChEBI:CHEBI:456216; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60149; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=A4Q9F4-1; Sequence=Displayed; Name=2 ; IsoId=A4Q9F4-2; Sequence=VSP_052719; Name=3 ; IsoId=A4Q9F4-3; Sequence=VSP_052718, VSP_052719; Highly expressed in brain, kidney, liver, lung, muscle and testis (PubMed:17499049). Expressed in heart, spleen and trachea (PubMed:17499049). In the brain, expressed in ependymal cilia, cortex, corpus callosum and striatum (PubMed:23897886). The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding. Gln-252 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate- chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation. Belongs to the tubulin--tyrosine ligase family. Sequence=BAB30318.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB30318.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAB30318.1; Type=Frameshift; Evidence=; nucleotide binding molecular_function ATP binding cellular_component cytoplasm cytoskeleton microtubule cilium cellular protein modification process ligase activity protein polyglutamylation cell projection microtubule severing uc008jkz.1 uc008jkz.2 uc008jkz.3 uc008jkz.4 uc008jkz.5 
ENSMUST00000028250.9 Mrrf ENSMUST00000028250.9 mitochondrial ribosome recycling factor (from RefSeq NM_026422.2) B1B055 ENSMUST00000028250.1 ENSMUST00000028250.2 ENSMUST00000028250.3 ENSMUST00000028250.4 ENSMUST00000028250.5 ENSMUST00000028250.6 ENSMUST00000028250.7 ENSMUST00000028250.8 NM_026422 Q9D6S7 RRFM_MOUSE uc008jlj.1 uc008jlj.2 uc008jlj.3 uc008jlj.4 uc008jlj.5 Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with GFM2. Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts. Mitochondrion Belongs to the RRF family. mitochondrion translation ribosome disassembly ribosomal large subunit binding uc008jlj.1 uc008jlj.2 uc008jlj.3 uc008jlj.4 uc008jlj.5 
ENSMUST00000028251.10 Rbm18 ENSMUST00000028251.10 RNA binding motif protein 18, transcript variant 3 (from RefSeq NR_027515.1) ENSMUST00000028251.1 ENSMUST00000028251.2 ENSMUST00000028251.3 ENSMUST00000028251.4 ENSMUST00000028251.5 ENSMUST00000028251.6 ENSMUST00000028251.7 ENSMUST00000028251.8 ENSMUST00000028251.9 NR_027515 Q8CBD4 Q9CR83 RBM18_MOUSE uc008jlh.1 uc008jlh.2 uc008jlh.3 uc008jlh.4 nucleic acid binding RNA binding cellular_component uc008jlh.1 uc008jlh.2 uc008jlh.3 uc008jlh.4 
ENSMUST00000028252.14 Grb14 ENSMUST00000028252.14 growth factor receptor bound protein 14, transcript variant 1 (from RefSeq NM_016719.2) ENSMUST00000028252.1 ENSMUST00000028252.10 ENSMUST00000028252.11 ENSMUST00000028252.12 ENSMUST00000028252.13 ENSMUST00000028252.2 ENSMUST00000028252.3 ENSMUST00000028252.4 ENSMUST00000028252.5 ENSMUST00000028252.6 ENSMUST00000028252.7 ENSMUST00000028252.8 ENSMUST00000028252.9 GRB14_MOUSE NM_016719 Q3UI77 Q8VDI2 Q9CR03 Q9JLM9 uc008jvx.1 uc008jvx.2 uc008jvx.3 uc008jvx.4 uc008jvx.5 Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity). Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor, through the SH2 domain. Interacts with GRB14 (via BPS domain); this interaction protects the tyrosines in the activation loop on INSR from dephosphorylation (By similarity). Binds to the ankyrin repeat region of TNKS2 via its N-terminus. Interacts with activated NRAS (By similarity). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Q9JLM9; P29973: CNGA1; Xeno; NbExp=2; IntAct=EBI-8347358, EBI-8417095; Cytoplasm Endosome membrane ; Peripheral membrane protein Note=Upon insulin stimulation, translocates to the plasma membrane. The PH domain binds relatively non-specifically and with low affinity to several phosphoinositides, the best binder being PI(3,4,5)P3. Phosphorylated on serine residues. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity). Belongs to the GRB7/10/14 family. SH3/SH2 adaptor activity protein binding cytoplasm endosome Golgi apparatus plasma membrane signal transduction insulin receptor signaling pathway positive regulation of signal transduction endosome membrane membrane receptor tyrosine kinase binding cellular response to insulin stimulus identical protein binding protein homodimerization activity intracellular membrane-bounded organelle negative regulation of insulin receptor signaling pathway phosphoprotein binding negative regulation of meiotic cell cycle process involved in oocyte maturation uc008jvx.1 uc008jvx.2 uc008jvx.3 uc008jvx.4 uc008jvx.5 
ENSMUST00000028256.5 Morn5 ENSMUST00000028256.5 MORN repeat containing 5 (from RefSeq NM_029309.2) ENSMUST00000028256.1 ENSMUST00000028256.2 ENSMUST00000028256.3 ENSMUST00000028256.4 MORN5_MOUSE NM_029309 Q9DAI9 uc008jlc.1 uc008jlc.2 uc008jlc.3 Cell projection, cilium, flagellum Only detected in testis (at protein level). Detected in testis at 21 days after birth and expression is maintained (PubMed:28742876). Expressed in mature sperm (PubMed:28742876). molecular_function cellular_component biological_process uc008jlc.1 uc008jlc.2 uc008jlc.3 
ENSMUST00000028257.3 Gca ENSMUST00000028257.3 grancalcin (from RefSeq NM_145523.3) ENSMUST00000028257.1 ENSMUST00000028257.2 GRAN_MOUSE NM_145523 Q8BL53 Q8K3Z6 Q8VC88 uc008jvp.1 uc008jvp.2 uc008jvp.3 Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions. Homodimer. Interacts with SRI and LCP1 (By similarity). Cytoplasm Cytoplasmic granule membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels. No visible phenotype. Not essential for normal resistance to microbial infections. Grancalcin-deficient neutrophils exhibit decreased adhesion to fibronectin, and a strongly reduced number of focal adhesion complexes. This protein has been shown to bind calcium with high affinity. calcium ion binding cytoplasm cytosol plasma membrane membrane protein homodimerization activity metal ion binding protein heterodimerization activity uc008jvp.1 uc008jvp.2 uc008jvp.3 
ENSMUST00000028259.12 Ifih1 ENSMUST00000028259.12 interferon induced with helicase C domain 1, transcript variant 1 (from RefSeq NM_027835.3) A2AUY7 ENSMUST00000028259.1 ENSMUST00000028259.10 ENSMUST00000028259.11 ENSMUST00000028259.2 ENSMUST00000028259.3 ENSMUST00000028259.4 ENSMUST00000028259.5 ENSMUST00000028259.6 ENSMUST00000028259.7 ENSMUST00000028259.8 ENSMUST00000028259.9 IFIH1_MOUSE Ifih1 NM_027835 Q3U6S2 Q68EM4 Q8BYC9 Q8BZ01 Q8K5C7 Q8R144 Q8R5F7 Q8VE79 Q99KS4 Q9D2Z5 uc008jvm.1 uc008jvm.2 uc008jvm.3 uc008jvm.4 Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long- dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN- alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and theiler's murine encephalomyelitis virus (TMEV). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Monomer in the absence of ligands and homodimerizes in the presence of dsRNA ligands. Can assemble into helical or linear polymeric filaments on long dsRNA. Interacts with MAVS/IPS1. Interacts (via the CARD domains) with TKFC, the interaction is inhibited by viral infection. Interacts with PCBP2. Interacts with NLRC5. Interacts with PIAS2-beta. Interacts with DDX60. Interacts with ANKRD17. Interacts with IKBKE. Interacts with ATG5 and ATG12, either as ATG5 and ATG12 monomers or as ATG12-ATG5 conjugates. Interacts with ZCCHC3; leading to activate IFIH1/MDA5. Interacts with RNF123. Interacts with DDX3X. Interacts with NOD1; this interaction promotes transcription of antiviral genes and inhibition of viral replication. Interacts with ECSIT; this interaction bridges IFIH1 to the MAVS complex at the mitochondrion. Q8R5F7-1; P11207: P/V; Xeno; NbExp=3; IntAct=EBI-16019291, EBI-6148694; Cytoplasm Nucleus Mitochondrion Note=Upon viral RNA stimulation and ISGylation, translocates from cytosol to mitochondrion. May be found in the nucleus, during apoptosis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R5F7-1; Sequence=Displayed; Name=2; IsoId=Q8R5F7-2; Sequence=VSP_013339; Expression is prominent in lung, liver, kidney, heart and spleen (at protein level). Widely expressed at low level. By interferon (IFN). During apoptosis, processed into 3 cleavage products. The helicase-containing fragment, once liberated from the CARD domains, translocate from the cytoplasm to the nucleus. The processed protein significantly sensitizes cells to DNA degradation. Sumoylated. Sumoylation positively regulates its role in type I interferon induction and is enhanced by PIAS2-beta. Ubiquitinated by RNF125, leading to its degradation by the proteasome. USP17/UPS17L2-dependent deubiquitination positively regulates the receptor. Ubiquitinated by TRIM25 via 'Lys-63'-linked ubiquitination, promoting activation of IFIH1/MDA5. Ubiquitinated by TRIM40 via 'Lys-48'-linked ubiquitination; leading to proteasomal degradation. Ubiquitinated by TRIM65 via 'Lys-63'-linked ubiquitination, promoting activation of IFIH1/MDA5. ISGylated by ISG15. ISGylation increases upon infection with viruses. ISGylation at Lys-23 and Lys-43 is dependent of dephosphorylation, regulates mitochondrial translocation and oligomerization. Essential for IFIH1/MDA5-mediated cytokine responses and restriction of virus replication. Phosphorylated. Dephosphorylated by phsophatases PP1; dephosphorylation precedes and is required for ISGylation. Belongs to the helicase family. RLR subfamily. Sequence=AAH25508.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding immune system process DNA binding RNA binding RNA helicase activity double-stranded RNA binding single-stranded RNA binding helicase activity protein binding ATP binding nucleus cytoplasm zinc ion binding response to virus hydrolase activity protein sumoylation positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta secretion MDA-5 signaling pathway identical protein binding ribonucleoprotein complex binding innate immune response metal ion binding defense response to virus positive regulation of response to cytokine stimulus cellular response to exogenous dsRNA positive regulation of interferon-alpha secretion positive regulation of tumor necrosis factor secretion positive regulation of interleukin-6 secretion uc008jvm.1 uc008jvm.2 uc008jvm.3 uc008jvm.4 
ENSMUST00000028278.14 Psmd14 ENSMUST00000028278.14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 (from RefSeq NM_021526.2) ENSMUST00000028278.1 ENSMUST00000028278.10 ENSMUST00000028278.11 ENSMUST00000028278.12 ENSMUST00000028278.13 ENSMUST00000028278.2 ENSMUST00000028278.3 ENSMUST00000028278.4 ENSMUST00000028278.5 ENSMUST00000028278.6 ENSMUST00000028278.7 ENSMUST00000028278.8 ENSMUST00000028278.9 NM_021526 O35593 PSDE_MOUSE Pad1 Q3UB50 Q9CZY6 uc008jvc.1 uc008jvc.2 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD4, a base containing 6 ATPases and few additional components. Within the complex, PSMD4 interacts with subunit PSMD7 through their respective MPN domain. Interacts with TXNL1. O35593; Q16186: ADRM1; Xeno; NbExp=2; IntAct=EBI-772796, EBI-954387; Belongs to the peptidase M67A family. PSMD14 subfamily. proteasome complex double-strand break repair via homologous recombination endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding DNA repair double-strand break repair via nonhomologous end joining proteolysis cellular response to DNA damage stimulus peptidase activity metallopeptidase activity proteasome regulatory particle, lid subcomplex positive regulation of endopeptidase activity protein deubiquitination hydrolase activity proteasome accessory complex cytosolic proteasome complex thiol-dependent ubiquitinyl hydrolase activity proteasome-mediated ubiquitin-dependent protein catabolic process response to ethanol metal ion binding endopeptidase activator activity regulation of proteasomal protein catabolic process Lys63-specific deubiquitinase activity protein K63-linked deubiquitination proteasome binding uc008jvc.1 uc008jvc.2 
ENSMUST00000028280.14 Col5a1 ENSMUST00000028280.14 collagen, type V, alpha 1 (from RefSeq NM_015734.2) A3KGE3 CO5A1_MOUSE ENSMUST00000028280.1 ENSMUST00000028280.10 ENSMUST00000028280.11 ENSMUST00000028280.12 ENSMUST00000028280.13 ENSMUST00000028280.2 ENSMUST00000028280.3 ENSMUST00000028280.4 ENSMUST00000028280.5 ENSMUST00000028280.6 ENSMUST00000028280.7 ENSMUST00000028280.8 ENSMUST00000028280.9 NM_015734 O88207 Q3UG94 Q6F6B0 uc008ixt.1 uc008ixt.2 uc008ixt.3 uc008ixt.4 Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity). Transcriptionally activated by CEBPZ, which recognizes a CCAAT-like motif, CAAAT in the COL5A1 promoter. Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4 (By similarity). Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A ; IsoId=O88207-1; Sequence=Displayed; Name=2; Synonyms=B ; IsoId=O88207-2; Sequence=VSP_059656; Widely expressed (PubMed:22149965). Isoform 2 is more highly expressed in liver, kidney and lung (PubMed:22149965). Detected at 11 dpc, 12 dpc, 14 dpc, 16 dpc and 18 dpc. Expressed in limbs, vertebrae, heart, brain, liver, intestine, tongue, tail, skin, calvaria, lung and kidney of 18 dpc embryos (PubMed:9582436). Isoform 2 is detected at 13.5 dpc and its expression increases from 13.5 dpc to 5 weeks after birth more specially in liver, lung, ileum and heart. The expression slightly decreases after 15 weeks (PubMed:22149965). Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4- hydroxylation in vertebrates. Sulfated on 40% of tyrosines. Belongs to the fibrillar collagen family. blood vessel development heart morphogenesis extracellular matrix structural constituent protein binding extracellular region collagen trimer collagen type V trimer basement membrane extracellular space cell adhesion heparin binding cell migration extracellular matrix structural constituent conferring tensile strength extracellular matrix organization collagen fibril organization extracellular matrix collagen biosynthetic process wound healing, spreading of epidermal cells tendon development proteoglycan binding skin development integrin biosynthetic process platelet-derived growth factor binding eye morphogenesis regulation of cellular component organization supramolecular fiber organization negative regulation of endodermal cell differentiation uc008ixt.1 uc008ixt.2 uc008ixt.3 uc008ixt.4 
ENSMUST00000028283.2 Lcn4 ENSMUST00000028283.2 lipocalin 4 (from RefSeq NM_010695.1) ENSMUST00000028283.1 NM_010695 Q62472 VNS2_MOUSE uc008iwa.1 uc008iwa.2 Transport of lipophilic molecules, possible pheromone- carrier. Secreted. Specifically expressed in vomeronasal and posterior glands of the nasal septum, the ducts of which open into the lumen of the vomeronasal organ. Belongs to the calycin superfamily. Lipocalin family. pheromone binding cellular_component extracellular region biological_process small molecule binding uc008iwa.1 uc008iwa.2 
ENSMUST00000028286.12 Agpat2 ENSMUST00000028286.12 1-acylglycerol-3-phosphate O-acyltransferase 2 (from RefSeq NM_026212.2) ENSMUST00000028286.1 ENSMUST00000028286.10 ENSMUST00000028286.11 ENSMUST00000028286.2 ENSMUST00000028286.3 ENSMUST00000028286.4 ENSMUST00000028286.5 ENSMUST00000028286.6 ENSMUST00000028286.7 ENSMUST00000028286.8 ENSMUST00000028286.9 NM_026212 PLCB_MOUSE Q8K3K7 uc008ivt.1 uc008ivt.2 uc008ivt.3 uc008ivt.4 Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19710; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74544, ChEBI:CHEBI:74546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37132; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37143, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74544, ChEBI:CHEBI:74551; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37144; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37155, ChEBI:CHEBI:57287, ChEBI:CHEBI:74307, ChEBI:CHEBI:74544, ChEBI:CHEBI:74558; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37156; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero- 3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn- glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37159, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74544, ChEBI:CHEBI:74563; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37160; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37171, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:74544, ChEBI:CHEBI:74579; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37172; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37175, ChEBI:CHEBI:57287, ChEBI:CHEBI:74309, ChEBI:CHEBI:74544, ChEBI:CHEBI:74578; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37176; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:33187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57518, ChEBI:CHEBI:64839; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33188; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3- phosphate = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3- phosphate + CoA; Xref=Rhea:RHEA:37187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72683, ChEBI:CHEBI:74586; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37188; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn- glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)- octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37139, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74549, ChEBI:CHEBI:74550; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37140; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn- glycero-3-phosphate = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)- octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37179, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74581, ChEBI:CHEBI:74582; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37180; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37183, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74583, ChEBI:CHEBI:74584; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37184; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1- hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:35907, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57518, ChEBI:CHEBI:72857; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35908; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn- glycero-3-phosphate = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:35915, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:57518, ChEBI:CHEBI:72864; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35916; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:35903, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57518, ChEBI:CHEBI:72859; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35904; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1- hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:35899, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:57518, ChEBI:CHEBI:72858; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35900; Evidence=; Reaction=(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3- phosphate + CoA; Xref=Rhea:RHEA:37603, ChEBI:CHEBI:57287, ChEBI:CHEBI:74544, ChEBI:CHEBI:75121, ChEBI:CHEBI:75122; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37604; Evidence=; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 2/3. Endoplasmic reticulum membrane ; Multi-pass membrane protein Expressed at high levels in the liver, at intermediate levels in the kidney, gut, heart and skeletal muscles. Undetectable in brain and spleen. Down-regulated in the heart by clofibrate, a PPAR-alpha agonist. The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. positive regulation of cytokine production 1-acylglycerol-3-phosphate O-acyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phosphatidic acid biosynthetic process epidermis development phospholipid biosynthetic process membrane integral component of membrane CDP-diacylglycerol biosynthetic process transferase activity transferase activity, transferring acyl groups response to drug uc008ivt.1 uc008ivt.2 uc008ivt.3 uc008ivt.4 
ENSMUST00000028288.5 Notch1 ENSMUST00000028288.5 notch 1 (from RefSeq NM_008714.3) ENSMUST00000028288.1 ENSMUST00000028288.2 ENSMUST00000028288.3 ENSMUST00000028288.4 Motch NM_008714 NOTC1_MOUSE Q01705 Q06007 Q3TZW2 Q3U3Y2 Q61905 Q7TQ50 Q7TQ51 Q7TQ52 Q8K428 Q99JC2 Q9QW58 Q9R0X7 uc008ivl.1 uc008ivl.2 uc008ivl.3 uc008ivl.4 Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. Notch 1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF- 1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Forms a trimeric complex with FBXW7 and SGK1. Interacts with HIF1AN. HIF1AN negatively regulates the function of notch intracellular domain (NICD), accelerating myogenic differentiation. Interacts (via NICD) with SNAI1 (via zinc fingers); the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts (via NICD) with MDM2A. Interacts (via NICD) with BCL6; the interaction decreases MAML1 recruitment by NOTCH1 NICD on target genes DNA and inhibits NOTCH1 transcractivation activity. Interacts with THBS4. Interacts (via the EGF-like repeat region) with CCN3 (via CTCK domain) (PubMed:12050162). Interacts (via EGF-like domains) with DLL4 (via N- terminal DSL and MNNL domains) (By similarity). Interacts with ZMIZ1. Interacts (via NICD domain) with MEGF10 (via the cytoplasmic domain) (PubMed:28498977). Interacts with DLL1 and JAG1 (PubMed:28089369). Interacts (via NICD domain) with PRAG1 (PubMed:25038227). Forms a complex with PRAG1, N1ICD and MAML1, in a MAML1-dependent manner (PubMed:25038227). Interacts (via transmembrane region) with PSEN1; the interaction is direct (By similarity). Interacts with ZFP64 (PubMed:18430783). Q01705; P31266: Rbpj; NbExp=8; IntAct=EBI-1392707, EBI-1392666; Q01705; Q3TKT4: Smarca4; NbExp=2; IntAct=EBI-1392707, EBI-1210244; Q01705; Q6P9Z1: Smarcd3; NbExp=2; IntAct=EBI-1392707, EBI-7525857; Q01705; P62991: Ubc; NbExp=3; IntAct=EBI-1392707, EBI-413074; Q01705; Q06330: RBPJ; Xeno; NbExp=3; IntAct=EBI-1392707, EBI-632552; Q01705; P28159: Su(H); Xeno; NbExp=3; IntAct=EBI-1392707, EBI-92180; PRO_0000007679; Q77CA8: LRORF2; Xeno; NbExp=3; IntAct=EBI-11292892, EBI-11292862; Cell membrane ingle-pass type I membrane protein. [Notch 1 intracellular domain]: Nucleus Note=Following proteolytical processing NICD is translocated to the nucleus. Nuclear location may require MEGF10. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q01705-1; Sequence=Displayed; Name=2; IsoId=Q01705-2; Sequence=VSP_001402, VSP_001403, VSP_001404; Name=3; IsoId=Q01705-3; Sequence=VSP_043064; Name=4; IsoId=Q01705-4; Sequence=VSP_043065; Highly expressed in the brain, lung and thymus. Expressed at lower levels in the spleen, bone-marrow, spinal cord, eyes, mammary gland, liver, intestine, skeletal muscle, kidney and heart. In the hair follicle, highly expressed exclusively in the epithelial compartment. First detected in the mesoderm at 7.5 dpc By 8.5 dpc highly expressed in presomitic mesoderm, mesenchyme and endothelial cells, while much lower levels are seen in the neuroepithelium. Between 9.5-10.5 dpc expressed at high levels in the neuroepithelium. At 13.5 dpc expressed in the surface ectoderm, eye and developing whisker follicles. Hair follicle matrix cells expression starts as different cell types become distinguishable in the developing follicle. Expression persists throughout the growth phase of the follicle and maintains the same expression profile in the second hair cycle. The cells in the follicle that undergo a phase of high level expression are in transition from mitotic precursors to several discrete, differentiating cell types. Specifically expressed in cerebellar Bergmann glial cells during postnatal development. Interaction with PSEN1 causes partial unwinding of the transmembrane helix, facilitating access to the scissile peptide bond. Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans- Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form (PubMed:10882062, PubMed:10882063). Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by ADAM17 to yield a membrane- associated intermediate fragment called notch extracellular truncation (NEXT) (PubMed:10882062, PubMed:10882063). Following endocytosis, this fragment is then cleaved by one of the catalytic subunits of gamma- secretase (PSEN1 or PSEN2) to release a Notch-derived peptide containing the intracellular domain (NICD) from the membrane (PubMed:10882062, PubMed:11518718, PubMed:11459941). Phosphorylated. O-linked glycosylation by GALNT11 is involved in determination of left/right symmetry: glycosylation promotes activation of NOTCH1, possibly by promoting cleavage by ADAM17, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity). O-glycosylated on the EGF-like domains (PubMed:21757702). O-glucosylated at Ser-435 by KDELC1 and KDELC2 (PubMed:30127001). Contains both O-linked fucose and O-linked glucose in the EGF-like domains 11, 12 and 13, which are interacting with the residues on DLL4 (By similarity). O-glycosylation at Ser-1027 is only partial (PubMed:21757702). MFNG-, RFNG- and LFNG-mediated modification of O-fucose residues at specific EGF-like domains results in inhibition of its activation by JAG1 and enhancement of its activation by DLL1 via an increased binding to DLL1 (PubMed:28089369). Ubiquitinated. Undergoes 'Lys-29'-linked polyubiquitination by ITCH; promotes the lysosomal degradation of non-activated internalized NOTCH1 (PubMed:18628966, PubMed:23886940). Monoubiquitination at Lys- 1749 is required for activation by gamma-secretase cleavage, it promotes interaction with AAK1, which stabilizes it. Deubiquitination by EIF3F is necessary for nuclear import of activated Notch (PubMed:15240571). Hydroxylated at Asn-1945 and Asn-2012 by HIF1AN. Hydroxylation reduces affinity for HI1AN and may thus indirectly modulate negative regulation of NICD. Belongs to the NOTCH family. negative regulation of transcription from RNA polymerase II promoter Golgi membrane RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis acrosomal vesicle in utero embryonic development cell fate specification ruffle epithelial to mesenchymal transition liver development heart looping sprouting angiogenesis osteoblast fate commitment positive regulation of neuroblast proliferation MAML1-RBP-Jkappa- ICN1 complex inflammatory response to antigenic stimulus outflow tract morphogenesis endocardium development endocardium morphogenesis atrioventricular node development coronary vein morphogenesis aortic valve morphogenesis atrioventricular valve morphogenesis coronary sinus valve morphogenesis pulmonary valve morphogenesis mitral valve formation endocardial cushion development epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis cardiac chamber formation cardiac ventricle morphogenesis cardiac atrium morphogenesis cardiac right atrium morphogenesis cardiac left ventricle morphogenesis cardiac right ventricle formation ventricular trabecula myocardium morphogenesis growth involved in heart morphogenesis negative regulation of cell proliferation involved in heart valve morphogenesis regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation regulation of cardioblast proliferation Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation cell migration involved in endocardial cushion formation negative regulation of extracellular matrix constituent secretion pericardium morphogenesis chromatin binding transcription factor activity, sequence-specific DNA binding enzyme inhibitor activity transmembrane signaling receptor activity Notch binding calcium ion binding protein binding extracellular region nucleus nucleoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol cytoskeleton plasma membrane integral component of plasma membrane adherens junction regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter humoral immune response cell cycle arrest Notch signaling pathway positive regulation of transcription of Notch receptor target multicellular organism development spermatogenesis determination of left/right symmetry compartment pattern specification axonogenesis brain development foregut morphogenesis endoderm development heart development positive regulation of cell proliferation negative regulation of cell proliferation epidermis development regulation of Notch signaling pathway auditory receptor cell fate commitment cell surface glial cell differentiation regulation of gene expression negative regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of cell-substrate adhesion negative regulation of myotube differentiation mesenchymal cell development regulation of somitogenesis membrane integral component of membrane apical plasma membrane enzyme binding cell differentiation in spinal cord neural tube development lamellipodium cell differentiation neuron differentiation keratinocyte differentiation negative regulation of ossification lung development embryonic limb morphogenesis regulation of cell migration positive regulation of cell migration positive regulation of BMP signaling pathway negative regulation of BMP signaling pathway forebrain development hair follicle morphogenesis animal organ regeneration cytoplasmic vesicle chromatin DNA binding response to corticosteroid response to muramyl dipeptide response to lipopolysaccharide embryonic hindlimb morphogenesis tube formation skeletal muscle cell differentiation cellular response to vascular endothelial growth factor stimulus signaling receptor activity regulation of cell proliferation tissue regeneration positive regulation of apoptotic process negative regulation of catalytic activity receptor complex sequence-specific DNA binding positive regulation of viral genome replication cell fate commitment negative regulation of cell differentiation positive regulation of endothelial cell differentiation regulation of auditory receptor cell differentiation negative regulation of auditory receptor cell differentiation positive regulation of keratinocyte differentiation negative regulation of myoblast differentiation negative regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of glial cell differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of calcium ion-dependent exocytosis negative regulation of growth rate positive regulation of JAK-STAT cascade negative regulation of photoreceptor cell differentiation positive regulation of Ras protein signal transduction metal ion binding somatic stem cell division neuron fate commitment astrocyte differentiation oligodendrocyte differentiation positive regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation branching morphogenesis of an epithelial tube venous blood vessel morphogenesis homeostasis of number of cells within a tissue positive regulation of viral transcription regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation regulation of neurogenesis negative regulation of neurogenesis regulation of developmental process cardiac muscle tissue morphogenesis cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation negative regulation of glial cell proliferation cilium assembly cardiac epithelial to mesenchymal transition cardiac septum morphogenesis ventricular septum morphogenesis secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development negative regulation of cell death prostate gland epithelium morphogenesis regulation of epithelial cell proliferation involved in prostate gland development arterial endothelial cell differentiation venous endothelial cell differentiation cardiac vascular smooth muscle cell development endocardial cell differentiation vasculogenesis involved in coronary vascular morphogenesis coronary artery morphogenesis Notch signaling involved in heart development regulation of cell adhesion involved in heart morphogenesis heart trabecula morphogenesis positive regulation of transcription from RNA polymerase II promoter in response to hypoxia negative regulation of biomineral tissue development positive regulation of ERK1 and ERK2 cascade left/right axis specification cellular response to follicle-stimulating hormone stimulus cell periphery distal tubule development collecting duct development glomerular mesangial cell development interleukin-4 secretion negative regulation of cell migration involved in sprouting angiogenesis negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance positive regulation of ephrin receptor signaling pathway regulation of extracellular matrix assembly apoptotic process involved in embryonic digit morphogenesis positive regulation of apoptotic process involved in morphogenesis positive regulation of aorta morphogenesis negative regulation of stem cell differentiation negative regulation of anoikis negative regulation of pro-B cell differentiation negative regulation of endothelial cell chemotaxis uc008ivl.1 uc008ivl.2 uc008ivl.3 uc008ivl.4 
ENSMUST00000028294.7 Card9 ENSMUST00000028294.7 caspase recruitment domain family, member 9 (from RefSeq NM_001037747.3) A2AIV8 CARD9_MOUSE Card9 ENSMUST00000028294.1 ENSMUST00000028294.2 ENSMUST00000028294.3 ENSMUST00000028294.4 ENSMUST00000028294.5 ENSMUST00000028294.6 NM_001037747 uc289ucz.1 uc289ucz.2 Adapter protein that plays a key role in innate immune response against fungi by forming signaling complexes downstream of C- type lectin receptors (PubMed:16862125, PubMed:20538615, PubMed:26679537, PubMed:29080677). CARD9-mediated signals are essential for antifungal immunity against a subset of fungi from the phylum Ascomycota (PubMed:16862125, PubMed:20538615, PubMed:24470469, PubMed:25621893, PubMed:26679537, PubMed:29080677, PubMed:32548948). Transduces signals in myeloid cells downstream of C-type lectin receptors CLEC7A (dectin-1), CLEC6A (dectin-2) and CLEC4E (Mincle), which detect pathogen-associated molecular pattern metabolites (PAMPs), such as fungal carbohydrates, and trigger CARD9 activation (PubMed:16862125, PubMed:20538615). Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:16862125, PubMed:20538615, PubMed:22265677, PubMed:29080677). CARD9 signaling in antigen- presenting cells links innate sensing of fungi to the activation of adaptive immunity and provides a cytokine milieu that induces the development and subsequent of interleukin 17-producing T helper (Th17) cells (PubMed:17450144, PubMed:24470469, PubMed:32358020). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (PubMed:17486093). CARD9 can also be engaged independently of BCL10: forms a complex with RASGRF1 downstream of C-type lectin receptors, which recruits and activates HRAS, leading to ERK activation and the production of cytokines (PubMed:25267792). Acts as an important regulator of the intestinal commensal fungi (mycobiota) component of the gut microbiota (PubMed:27158904, PubMed:33548172). Plays an essential role in antifungal immunity against dissemination of gut fungi: acts by promoting induction of antifungal IgG antibodies response in CX3CR1(+) macrophages to confer protection against disseminated C.albicans or C.auris infection (PubMed:33548172). Also mediates immunity against other pathogens, such as certain bacteria, viruses and parasites; CARD9 signaling is however redundant with other innate immune responses (PubMed:17187069, PubMed:26679537, PubMed:29080677). In response to L.monocytogenes infection, required for the production of inflammatory cytokines activated by intracellular peptidoglycan: acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF- kappa-B (PubMed:17187069). Maintained in an autoinhibited state via homodimerization in which the CARD domain forms an extensive interaction with the adjacent linker and coiled-coil regions (By similarity). Activation downstream of C-type lectin receptors, by phosphorylation by PRKCD and/or ubiquitination by TRIM62, triggers disruption of the CARD domain-coiled coil interface, CARD9 homooligomerization and BCL10 recruitment, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:22265677). Zinc-binding inhibits activation by stabilizing the CARD ground-state conformation and restricting its capacity to form BCL10-nucleating filaments (By similarity). Monomer (By similarity). Homodimer; homodimerization is mediated by the CARD domain which forms an extensive interaction with the adjacent linker and coiled-coil regions; leads to an autoinhibited state (By similarity). Homomultimer; polymerizes following activation, forming a nucleating helical template that seeds BCL10-filament formation via a CARD-CARD interaction (By similarity). Interacts (via CARD domain) with BCL10 (via CARD domain); interaction takes place following CARD9 activation and polymerization, leading to the formation of a filamentous CBM complex assembly (PubMed:22265677). Component of a CBM complex (CARD9-BCL10, MALT1), composed of CARD9, BCL10 and MALT1 (PubMed:22265677). Interacts with RASGRF1 (By similarity). Interacts with NOD2 (via NACHT domain); interaction is direct (PubMed:17187069, PubMed:24960071). Interacts with RIPK2 (PubMed:17187069). Interacts with VHL; without leading to protein degradation (By similarity). Cytoplasm Specifically expressed in myeloid cells (PubMed:16862125, PubMed:17187069). Not expressed in non-lymphoid organs (PubMed:16862125, PubMed:17187069). The linker region, also named autoinhibitory interface, is required to prevent constitutive activation and maintain CARD9 in an autoinhibitory state. Disruption of this region triggers polymerization and activation, leading to formation of BCL10-nucleating filaments. Phosphorylated at Thr-231 by PRKCD downstream of C-type lectin receptors activation: phosphorylation promotes interaction with BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:22265677). Phosphorylated at Thr-531 and Thr-531 by CK2 following interaction with VHL, leading to inhibit the ability to activate NF-kappa-B (By similarity). Ubiquitinated at Lys-125 via 'Lys-27'-linked ubiquitin by TRIM62 downstream of C-type lectin receptors activation; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Deubiquitinated at Lys-125 by USP15, inhibiting CARD9 (By similarity). Mice were born at the normal Mendelian ratio without obvious anatomical defects but display impaired innate immunity (PubMed:16862125, PubMed:17187069). In response to C.albicans infection, mice develop fungal infections, many of which target the central nervous system (CNS) (PubMed:26679537). All mice die within 5 days after infection by C.albicans whereas more than half of the control mice survive for more than 12 days (PubMed:16862125). Impaired zymosan-induced cytokine production (PubMed:16862125). No defects in adaptive immunity (PubMed:16862125). Mice show impaired recruitment of neutrophils in CNS after infection by C.albicans, an immune cell critical for antifungal host defense (PubMed:26679537). Mice are susceptible to pulmonary infection with C.neoformans and show decreased Th17-related immune response (PubMed:24470469). Mice are highly susceptible to phaeohyphomycosis following E.spinifera infection and show impaired antifungal immunity, characterized by reduced cytokine production and neutrophil recruitment (PubMed:29080677). Mice are susceptible to A.fumigatus and P.pneumonia infection (PubMed:25621893, PubMed:32548948). Mice are more susceptible to colitis and have an increased load of gut-resident fungi (mycobiota), causing gut fungal dysbiosis (PubMed:23732773, PubMed:27158904). Mice are unable to induce an efficient IgG antibody response against disseminated C.albicans infection (PubMed:33548172). Following infection by L.monocytogenes, mice fail to clear infection and show altered cytokine production (PubMed:17187069). immune system process protein binding cytoplasm cytosol I-kappaB kinase/NF-kappaB signaling response to fungus protein domain specific binding response to peptidoglycan response to muramyl dipeptide positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade macromolecular complex response to drug regulation of tumor necrosis factor biosynthetic process protein homodimerization activity regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process response to exogenous dsRNA regulation of interleukin-2 biosynthetic process innate immune response positive regulation of innate immune response regulation of interleukin-6 biosynthetic process positive regulation of JNK cascade CARD domain binding defense response to Gram-positive bacterium defense response to virus uc289ucz.1 uc289ucz.2 
ENSMUST00000028295.9 Dnlz ENSMUST00000028295.9 DNL-type zinc finger, transcript variant 1 (from RefSeq NM_026828.3) B2RTG5 D2Bwg1335e DNLZ_MOUSE ENSMUST00000028295.1 ENSMUST00000028295.2 ENSMUST00000028295.3 ENSMUST00000028295.4 ENSMUST00000028295.5 ENSMUST00000028295.6 ENSMUST00000028295.7 ENSMUST00000028295.8 NM_026828 Q9D113 uc008iur.1 uc008iur.2 uc008iur.3 uc008iur.4 May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation. Oligomerizes in a concentration-dependent fashion. Interacts with HSPA9 (By similarity). Mitochondrion nucleoplasm mitochondrion protein folding zinc ion binding protein import into mitochondrial matrix metal ion binding protein stabilization chaperone binding uc008iur.1 uc008iur.2 uc008iur.3 uc008iur.4 
ENSMUST00000028300.6 Nacc2 ENSMUST00000028300.6 nucleus accumbens associated 2, BEN and BTB (POZ) domain containing, transcript variant 1 (from RefSeq NM_026495.3) Btbd14a ENSMUST00000028300.1 ENSMUST00000028300.2 ENSMUST00000028300.3 ENSMUST00000028300.4 ENSMUST00000028300.5 NACC2_MOUSE NM_026495 Q3TZD3 Q8VDF8 Q9DCM7 uc008iuc.1 uc008iuc.2 uc008iuc.3 Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 (By similarity). Homooligomer; mediated by the BTB domain. Interacts with the NuRD complex. Interacts (via C-terminal part) with HDAC2. Interacts (via BTB domain) with MTA1, MTA2 and MTA3. Nucleus. Note=Predominantly associated with chromatin. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription corepressor activity histone deacetylase activity nucleus nucleolus mitochondrion negative regulation of cell proliferation histone deacetylation cellular protein complex localization protein homodimerization activity histone deacetylase binding macromolecular complex binding negative regulation of transcription, DNA-templated protein homooligomerization negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage uc008iuc.1 uc008iuc.2 uc008iuc.3 
ENSMUST00000028304.4 Lcn3 ENSMUST00000028304.4 Secreted (from UniProt Q14AJ3) D38580 ENSMUST00000028304.1 ENSMUST00000028304.2 ENSMUST00000028304.3 Lcn3 Q14AJ3 Q14AJ3_MOUSE uc008iti.1 uc008iti.2 Secreted Belongs to the calycin superfamily. Lipocalin family. small molecule binding uc008iti.1 uc008iti.2 
ENSMUST00000028306.13 Lcn5 ENSMUST00000028306.13 lipocalin 5, transcript variant 1 (from RefSeq NM_007947.3) A2AJB7 ENSMUST00000028306.1 ENSMUST00000028306.10 ENSMUST00000028306.11 ENSMUST00000028306.12 ENSMUST00000028306.2 ENSMUST00000028306.3 ENSMUST00000028306.4 ENSMUST00000028306.5 ENSMUST00000028306.6 ENSMUST00000028306.7 ENSMUST00000028306.8 ENSMUST00000028306.9 LCN5_MOUSE Lcn5 Mep10 NM_007947 O88787 Q3TS05 Q3UW42 Q9R2C6 uc008itb.1 uc008itb.2 uc008itb.3 uc008itb.4 This gene encodes a small secreted protein that is expressed in the epididymis and binds retinoic acid. The precursor protein is processed into both a longer major form and a shorter minor form. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. Associates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 13-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation. Secreted te=Synthesized by the mid and distal caput of the epididymis and secreted into the epididymal lumen. Event=Alternative splicing; Named isoforms=4; Name=1 ; IsoId=A2AJB7-1; Sequence=Displayed; Name=2 ; IsoId=A2AJB7-2; Sequence=VSP_052839; Name=3 ; IsoId=A2AJB7-3; Sequence=VSP_052840; Name=4 ; IsoId=A2AJB7-4; Sequence=VSP_052838; Epididymal fluid of the caudal and corpus regions (at protein level). Down-regulated to 11% of control levels 5 days after castration and is not detectable by 20 days (at protein level). Levels are partially restored by subsequent testosterone treatment. 2 different forms with differently processed N-termini exist. Belongs to the calycin superfamily. Lipocalin family. Sequence=AAD09351.1; Type=Erroneous initiation; Evidence=; retinoid binding extracellular region extracellular space small molecule binding retinoic acid metabolic process uc008itb.1 uc008itb.2 uc008itb.3 uc008itb.4 
ENSMUST00000028307.9 Fcna ENSMUST00000028307.9 ficolin A, transcript variant 1 (from RefSeq NM_007995.4) ENSMUST00000028307.1 ENSMUST00000028307.2 ENSMUST00000028307.3 ENSMUST00000028307.4 ENSMUST00000028307.5 ENSMUST00000028307.6 ENSMUST00000028307.7 ENSMUST00000028307.8 Fcna NM_007995 Q4FJM1 Q4FJM1_MOUSE uc008isz.1 uc008isz.2 uc008isz.3 Belongs to the ficolin lectin family. uc008isz.1 uc008isz.2 uc008isz.3 
ENSMUST00000028309.4 Ccdc183 ENSMUST00000028309.4 coiled-coil domain containing 183 (from RefSeq NM_029859.1) A2AJB1 CC183_MOUSE ENSMUST00000028309.1 ENSMUST00000028309.2 ENSMUST00000028309.3 Kiaa1984 NM_029859 Q9D5S3 uc012bsc.1 uc012bsc.2 uc012bsc.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AJB1-1; Sequence=Displayed; Name=2; IsoId=A2AJB1-2; Sequence=VSP_026485, VSP_026486; molecular_function uc012bsc.1 uc012bsc.2 uc012bsc.3 
ENSMUST00000028311.13 Traf2 ENSMUST00000028311.13 TNF receptor-associated factor 2, transcript variant 2 (from RefSeq NM_009422.3) ENSMUST00000028311.1 ENSMUST00000028311.10 ENSMUST00000028311.11 ENSMUST00000028311.12 ENSMUST00000028311.2 ENSMUST00000028311.3 ENSMUST00000028311.4 ENSMUST00000028311.5 ENSMUST00000028311.6 ENSMUST00000028311.7 ENSMUST00000028311.8 ENSMUST00000028311.9 NM_009422 Q3U8L1 Q3U8L1_MOUSE Traf2 uc008ism.1 uc008ism.2 uc008ism.3 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Cytoplasm Belongs to the TNF receptor-associated factor family. A subfamily. ubiquitin-protein transferase activity tumor necrosis factor receptor binding cytoplasm cytosol signal transduction activation of NF-kappaB-inducing kinase activity zinc ion binding tumor necrosis factor-mediated signaling pathway regulation of apoptotic process regulation of JNK cascade metal ion binding protein autoubiquitination uc008ism.1 uc008ism.2 uc008ism.3 
ENSMUST00000028312.13 Lcn12 ENSMUST00000028312.13 lipocalin 12 (from RefSeq NM_029958.1) ENSMUST00000028312.1 ENSMUST00000028312.10 ENSMUST00000028312.11 ENSMUST00000028312.12 ENSMUST00000028312.2 ENSMUST00000028312.3 ENSMUST00000028312.4 ENSMUST00000028312.5 ENSMUST00000028312.6 ENSMUST00000028312.7 ENSMUST00000028312.8 ENSMUST00000028312.9 LCN12_MOUSE NM_029958 Q6JVL5 uc008ish.1 uc008ish.2 Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity). Monomer. Secreted Expressed in epididymis. Belongs to the calycin superfamily. Lipocalin family. retinoic acid binding cellular_component extracellular region biological_process small molecule binding uc008ish.1 uc008ish.2 
ENSMUST00000028314.9 Nmi ENSMUST00000028314.9 N-myc (and STAT) interactor, transcript variant 3 (from RefSeq NM_019401.3) ENSMUST00000028314.1 ENSMUST00000028314.2 ENSMUST00000028314.3 ENSMUST00000028314.4 ENSMUST00000028314.5 ENSMUST00000028314.6 ENSMUST00000028314.7 ENSMUST00000028314.8 NM_019401 Nmi Q3UJ82 Q3UJ82_MOUSE uc008jqo.1 uc008jqo.2 uc008jqo.3 uc008jqo.4 Cytoplasm Nucleus Secreted Belongs to the NMI family. transcription cofactor activity nucleoplasm cytoplasm cytosol transcription from RNA polymerase II promoter identical protein binding interferon-gamma-mediated signaling pathway regulation of nucleic acid-templated transcription uc008jqo.1 uc008jqo.2 uc008jqo.3 uc008jqo.4 
ENSMUST00000028328.3 Entpd2 ENSMUST00000028328.3 ectonucleoside triphosphate diphosphohydrolase 2 (from RefSeq NM_009849.2) ENSMUST00000028328.1 ENSMUST00000028328.2 Entpd2 NM_009849 Q921R1 Q921R1_MOUSE uc008irw.1 uc008irw.2 uc008irw.3 uc008irw.4 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the GDA1/CD39 NTPase family. membrane integral component of membrane hydrolase activity uc008irw.1 uc008irw.2 uc008irw.3 uc008irw.4 
ENSMUST00000028332.8 Dpp7 ENSMUST00000028332.8 dipeptidylpeptidase 7, transcript variant 5 (from RefSeq NR_184846.1) DPP2_MOUSE Dpp2 ENSMUST00000028332.1 ENSMUST00000028332.2 ENSMUST00000028332.3 ENSMUST00000028332.4 ENSMUST00000028332.5 ENSMUST00000028332.6 ENSMUST00000028332.7 NR_184846 Q8R082 Q9ET22 Qpp uc008irq.1 uc008irq.2 uc008irq.3 Plays an important role in the degradation of some oligopeptides. Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.; EC=3.4.14.2; Homodimer. Lysosome Cytoplasmic vesicle Secreted Belongs to the peptidase S28 family. aminopeptidase activity extracellular region lysosome Golgi apparatus cytosol proteolysis peptidase activity serine-type peptidase activity dipeptidyl-peptidase activity hydrolase activity cytoplasmic vesicle vesicle intracellular membrane-bounded organelle uc008irq.1 uc008irq.2 uc008irq.3 
ENSMUST00000028336.7 Arl6ip6 ENSMUST00000028336.7 ADP-ribosylation factor-like 6 interacting protein 6 (from RefSeq NM_022989.4) AR6P6_MOUSE ENSMUST00000028336.1 ENSMUST00000028336.2 ENSMUST00000028336.3 ENSMUST00000028336.4 ENSMUST00000028336.5 ENSMUST00000028336.6 NM_022989 Q8BH07 Q8BSK7 Q8VCL3 Q9CY07 Q9D4R5 Q9WUH0 uc008jro.1 uc008jro.2 uc008jro.3 uc008jro.4 Nucleus inner membrane ; Multi-pass membrane protein Belongs to the ARL6IP6 family. Sequence=AAD33051.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence=; Sequence=BAB27377.1; Type=Frameshift; Evidence=; protein binding nuclear inner membrane biological_process membrane integral component of membrane uc008jro.1 uc008jro.2 uc008jro.3 uc008jro.4 
ENSMUST00000028337.7 Lrrc26 ENSMUST00000028337.7 leucine rich repeat containing 26 (from RefSeq NM_146117.2) ENSMUST00000028337.1 ENSMUST00000028337.2 ENSMUST00000028337.3 ENSMUST00000028337.4 ENSMUST00000028337.5 ENSMUST00000028337.6 LRC26_MOUSE NM_146117 Q3UUY1 Q91W20 uc008irg.1 uc008irg.2 uc008irg.3 uc008irg.4 Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium (By similarity). Interacts with KCNMA1. Cell membrane ; Single-pass type I membrane protein Cytoplasm, cytoskeleton Note=Localizes to the cytoplasm when expressed at high levels. The transmembrane domain is necessary for interaction with KCNMA1. voltage-gated potassium channel activity cytoplasm cytoskeleton plasma membrane integral component of plasma membrane ion transport voltage-gated potassium channel complex potassium channel regulator activity membrane integral component of membrane ion channel binding potassium ion transmembrane transport potassium channel activator activity positive regulation of voltage-gated potassium channel activity uc008irg.1 uc008irg.2 uc008irg.3 uc008irg.4 
ENSMUST00000028340.4 Tmem210 ENSMUST00000028340.4 transmembrane protein 210 (from RefSeq NM_030055.2) ENSMUST00000028340.1 ENSMUST00000028340.2 ENSMUST00000028340.3 NM_030055 Q9D2F0 TM210_MOUSE uc008irf.1 uc008irf.2 uc008irf.3 Membrane ; Single-pass type I membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc008irf.1 uc008irf.2 uc008irf.3 
ENSMUST00000028341.11 Anapc2 ENSMUST00000028341.11 anaphase promoting complex subunit 2 (from RefSeq NM_175300.4) ANC2_MOUSE ENSMUST00000028341.1 ENSMUST00000028341.10 ENSMUST00000028341.2 ENSMUST00000028341.3 ENSMUST00000028341.4 ENSMUST00000028341.5 ENSMUST00000028341.6 ENSMUST00000028341.7 ENSMUST00000028341.8 ENSMUST00000028341.9 NM_175300 Q3TCK5 Q8BZQ7 Q8R2Q1 uc008ird.1 uc008ird.2 uc008ird.3 uc008ird.4 This gene encodes a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle by ubiquitinating its specific substrates, such as mitotic cyclins and anaphase inhibitor, for subsequent degradation by the proteasome. [provided by RefSeq, Oct 2009]. ##Evidence-Data-START## Transcript exon combination :: AK033784.1, SRR1660811.201899.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. Protein modification; protein ubiquitination. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (By similarity). In the context of the APC/C complex, directly interacts with UBE2C and UBE2S (By similarity). Interacts (via cullin domain) with ANAPC11 and with UBCH10 (By similarity). Interacts with NEUROD2 (PubMed:19900895). Interacts with FBXO43; the interaction is direct. Belongs to the cullin family. nucleus anaphase-promoting complex ubiquitin-dependent protein catabolic process cell cycle nervous system development protein ubiquitination cell differentiation ubiquitin protein ligase binding positive regulation of synaptic plasticity positive regulation of axon extension positive regulation of dendrite morphogenesis cell division protein K11-linked ubiquitination positive regulation of synapse maturation uc008ird.1 uc008ird.2 uc008ird.3 uc008ird.4 
ENSMUST00000028342.7 Ssna1 ENSMUST00000028342.7 SS nuclear autoantigen 1 (from RefSeq NM_023464.2) ENSMUST00000028342.1 ENSMUST00000028342.2 ENSMUST00000028342.3 ENSMUST00000028342.4 ENSMUST00000028342.5 ENSMUST00000028342.6 MNCb-2711 NM_023464 Q9JJ94 SSNA1_MOUSE Ssna1 uc008irc.1 uc008irc.2 uc008irc.3 Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST (By similarity). Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules (By similarity). Plays a role in axon outgrowth and branching (PubMed:30250060). Required for cell division (By similarity). Self-associates to form fibrils. Also forms dimers as well as monomers. Interacts with SPAST. Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Midbody Cytoplasm, cytoskeleton, flagellum basal body Cytoplasm, cytoskeleton, flagellum axoneme Cell projection, axon Note=In sperm, strongly expressed in the basal body region with weaker expression in the axoneme (By similarity). Localizes to axon branching points in neurons (PubMed:30250060). Belongs to the SSNA1 family. nucleus cytoplasm centrosome microtubule organizing center cytoskeleton ciliary basal body intraciliary transport identical protein binding ciliary receptor clustering involved in smoothened signaling pathway uc008irc.1 uc008irc.2 uc008irc.3 
ENSMUST00000028346.4 Cimip2a ENSMUST00000028346.4 ciliary microtubule inner protein 2A, transcript variant 1 (from RefSeq NM_026624.4) CMI2A_MOUSE ENSMUST00000028346.1 ENSMUST00000028346.2 ENSMUST00000028346.3 Fam166a NM_026624 Q9D4K5 uc008iqr.1 uc008iqr.2 uc008iqr.3 uc008iqr.4 Probable microtubule inner protein (MIP) part of the dynein- decorated doublet microtubules (DMTs) in flagellum axoneme. Cytoplasm, cytoskeleton, flagellum axoneme Belongs to the CIMIP2 family. molecular_function biological_process uc008iqr.1 uc008iqr.2 uc008iqr.3 uc008iqr.4 
ENSMUST00000028347.13 Rbms1 ENSMUST00000028347.13 RNA binding motif, single stranded interacting protein 1, transcript variant 3 (from RefSeq NM_020296.2) ENSMUST00000028347.1 ENSMUST00000028347.10 ENSMUST00000028347.11 ENSMUST00000028347.12 ENSMUST00000028347.2 ENSMUST00000028347.3 ENSMUST00000028347.4 ENSMUST00000028347.5 ENSMUST00000028347.6 ENSMUST00000028347.7 ENSMUST00000028347.8 ENSMUST00000028347.9 Mssp Mssp1 NM_020296 Q3UI25 Q3UXU2 Q6PEU6 Q6PHC2 Q91W59 Q9WTK4 RBMS1_MOUSE uc008juu.1 uc008juu.2 uc008juu.3 uc008juu.4 Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q91W59-1; Sequence=Displayed; Name=2; IsoId=Q91W59-2; Sequence=VSP_011931; Name=3; IsoId=Q91W59-3; Sequence=VSP_011931, VSP_011932; Ubiquitous. Expressed in all tissues except testis. Sequence=AAH16501.2; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding RNA binding nucleus cytosol DNA replication ribonucleoprotein complex uc008juu.1 uc008juu.2 uc008juu.3 uc008juu.4 
ENSMUST00000028348.9 Itgb6 ENSMUST00000028348.9 integrin beta 6, transcript variant 1 (from RefSeq NM_001159564.1) ENSMUST00000028348.1 ENSMUST00000028348.2 ENSMUST00000028348.3 ENSMUST00000028348.4 ENSMUST00000028348.5 ENSMUST00000028348.6 ENSMUST00000028348.7 ENSMUST00000028348.8 ITB6_MOUSE NM_001159564 Q544J9 Q9Z0T9 uc008jul.1 uc008jul.2 uc008jul.3 uc008jul.4 Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (PubMed:10025398). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:10025398). Heterodimer of an alpha and a beta subunit (PubMed:10025398). Interacts with FLNB (By similarity). Interacts with HAX1 (By similarity). ITGAV:ITGB6 interacts with FBN1 (By similarity). ITGAV:ITGB6 interacts with TGFB1 (PubMed:10025398). Cell membrane ; Single-pass type I membrane protein Cell junction, focal adhesion The VWFA domain (or beta I domain) contains three cation- binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site. Belongs to the integrin beta chain family. integrin binding nucleoplasm centrosome focal adhesion inflammatory response cell adhesion cell-matrix adhesion integrin-mediated signaling pathway integrin complex external side of plasma membrane membrane integral component of membrane cell migration cell junction cell adhesion mediated by integrin integrin alphav-beta6 complex signaling receptor activity transforming growth factor-beta secretion receptor complex regulation of transforming growth factor beta activation uc008jul.1 uc008jul.2 uc008jul.3 uc008jul.4 
ENSMUST00000028349.14 Arrdc1 ENSMUST00000028349.14 arrestin domain containing 1, transcript variant 3 (from RefSeq NR_027876.1) A2AIS7 A2AIS8 ARRD1_MOUSE Arrdc1 ENSMUST00000028349.1 ENSMUST00000028349.10 ENSMUST00000028349.11 ENSMUST00000028349.12 ENSMUST00000028349.13 ENSMUST00000028349.2 ENSMUST00000028349.3 ENSMUST00000028349.4 ENSMUST00000028349.5 ENSMUST00000028349.6 ENSMUST00000028349.7 ENSMUST00000028349.8 ENSMUST00000028349.9 NR_027876 Q3TDT6 Q8VEG7 Q99KN1 uc008ipn.1 uc008ipn.2 uc008ipn.3 uc008ipn.4 Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (By similarity). By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). Interacts (via PPxY motifs) with ITCH (via WW domains); the interaction is direct and participates in the recruitment of the ubiquitin-protein ligase ITCH to the NOTCH1 receptor. Interacts with ARRB1 and ARRB2; the interaction is direct. Interacts with TSG101; may recruit TSG101 to the plasma membrane. Interacts (via PPxY motifs) with WWP2 (via WW domains); ubiquitinates ARRDC1. Interacts with SLC11A2; controls the incorporation of SLC11A2 into extracellular vesicles through an ubiquitination-dependent mechanism. Interacts with WWP1 (via WW domains). Interacts with NEDD4 (via WW domains). Interacts with PDCD6IP. Cell membrane Note=Also found in extracellular vesicles different from exosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99KN1-1; Sequence=Displayed; Name=2; IsoId=Q99KN1-2; Sequence=VSP_019543; The PPxY motifs mediate interaction with WW domain-containing ubiquitin-protein ligases. Ubiquitinated. Ubiquitination by WWP2; promotes localization to extracellular microvesicles. Ubiquitinated by WWP1. Belongs to the arrestin family. Sequence=AAH04091.1; Type=Erroneous initiation; Evidence=; plasma membrane ubiquitin-dependent protein catabolic process extracellular transport protein transport membrane protein ubiquitination cytoplasmic vesicle ubiquitin protein ligase binding identical protein binding negative regulation of Notch signaling pathway extracellular vesicle protein binding, bridging involved in substrate recognition for ubiquitination arrestin family protein binding uc008ipn.1 uc008ipn.2 uc008ipn.3 uc008ipn.4 
ENSMUST00000028350.9 Zmynd19 ENSMUST00000028350.9 zinc finger, MYND domain containing 19, transcript variant 1 (from RefSeq NM_026021.4) ENSMUST00000028350.1 ENSMUST00000028350.2 ENSMUST00000028350.3 ENSMUST00000028350.4 ENSMUST00000028350.5 ENSMUST00000028350.6 ENSMUST00000028350.7 ENSMUST00000028350.8 Mizip NM_026021 Q8K1T3 Q9CQG3 ZMY19_MOUSE uc008ipo.1 uc008ipo.2 uc008ipo.3 uc008ipo.4 May be involved as a regulatory molecule in GPR24/MCH-R1 signaling. Interacts with GPR24/MCH-R1. Cytoplasm Cell membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=MIZIPa; IsoId=Q9CQG3-1; Sequence=Displayed; Name=2; Synonyms=MIZIPb; IsoId=Q9CQG3-2; Sequence=VSP_010075; Expressed in brain. molecular_function cytoplasm plasma membrane biological_process membrane synapse metal ion binding uc008ipo.1 uc008ipo.2 uc008ipo.3 uc008ipo.4 
ENSMUST00000028351.9 Dph7 ENSMUST00000028351.9 diphthamine biosynethesis 7, transcript variant 1 (from RefSeq NM_026044.4) A2AJ86 DPH7_MOUSE ENSMUST00000028351.1 ENSMUST00000028351.2 ENSMUST00000028351.3 ENSMUST00000028351.4 ENSMUST00000028351.5 ENSMUST00000028351.6 ENSMUST00000028351.7 ENSMUST00000028351.8 NM_026044 Q5RJV7 Q8BIT9 Q9CYU6 Wdr85 uc008ipq.1 uc008ipq.2 uc008ipq.3 uc008ipq.4 Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2). Reaction=diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + H(+) + methanol; Xref=Rhea:RHEA:42656, Rhea:RHEA-COMP:10172, Rhea:RHEA-COMP:10173, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:79005, ChEBI:CHEBI:82696; EC=3.1.1.97; Evidence=; Protein modification; peptidyl-diphthamide biosynthesis. Interacts with INCA1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CYU6-1; Sequence=Displayed; Name=2; IsoId=Q9CYU6-2; Sequence=VSP_014526, VSP_014528; Belongs to the DPH7 family. Sequence=BC086486; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; molecular_function cellular_component hydrolase activity peptidyl-diphthamide biosynthetic process from peptidyl-histidine diphthine methylesterase activity uc008ipq.1 uc008ipq.2 uc008ipq.3 uc008ipq.4 
ENSMUST00000028355.11 Pax8 ENSMUST00000028355.11 paired box 8 (from RefSeq NM_011040.4) ENSMUST00000028355.1 ENSMUST00000028355.10 ENSMUST00000028355.2 ENSMUST00000028355.3 ENSMUST00000028355.4 ENSMUST00000028355.5 ENSMUST00000028355.6 ENSMUST00000028355.7 ENSMUST00000028355.8 ENSMUST00000028355.9 NM_011040 P97342 PAX8_MOUSE Pax-8 Q00288 Q6GU20 uc008ipb.1 uc008ipb.2 uc008ipb.3 uc008ipb.4 This gene encodes a member of a family of transcription factors that contain a characteristic N-terminal paired DNA-binding domain. The encoded protein is important for proper differentiation of the thyroid and the kidney. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Mar 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK052610.1, AK050717.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development. Interacts with WWTR1. Nucleus. Expressed in the developing excretory system and the thyroid gland. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding urogenital system development metanephros development branching involved in ureteric bud morphogenesis kidney development mesonephros development ventricular septum development mesenchymal to epithelial transition involved in metanephros morphogenesis DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex transcription, DNA-templated regulation of transcription, DNA-templated sulfur compound metabolic process multicellular organism development central nervous system development animal organ morphogenesis negative regulation of cardiac muscle cell apoptotic process cell differentiation thyroid gland development pronephric field specification inner ear morphogenesis regulation of apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter pronephros development cellular response to gonadotropin stimulus otic vesicle development S-shaped body morphogenesis kidney epithelium development positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis mesonephric tubule development metanephric epithelium development metanephric distal convoluted tubule development metanephric comma-shaped body morphogenesis metanephric S-shaped body morphogenesis metanephric nephron tubule formation negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis regulation of metanephric nephron tubule epithelial cell differentiation positive regulation of branching involved in ureteric bud morphogenesis negative regulation of mesenchymal cell apoptotic process involved in metanephros development negative regulation of apoptotic process involved in metanephric collecting duct development negative regulation of apoptotic process involved in metanephric nephron tubule development positive regulation of metanephric DCT cell differentiation positive regulation of thyroid hormone generation regulation of thyroid-stimulating hormone secretion uc008ipb.1 uc008ipb.2 uc008ipb.3 uc008ipb.4 
ENSMUST00000028360.8 Il36rn ENSMUST00000028360.8 interleukin 36 receptor antagonist, transcript variant 1 (from RefSeq NM_001146087.1) ENSMUST00000028360.1 ENSMUST00000028360.2 ENSMUST00000028360.3 ENSMUST00000028360.4 ENSMUST00000028360.5 ENSMUST00000028360.6 ENSMUST00000028360.7 Fil1d I36RA_MOUSE IL36RN Il1f5 Il1h3 Il1hy1 NM_001146087 Q9JIG2 Q9QYY1 uc008ios.1 uc008ios.2 uc008ios.3 uc008ios.4 Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Cytoplasm Secreted Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. Highly abundant in embryonic tissue and tissues containing epithelial cells. Removal of N-terminal methionine is necessary for full antagonistic activity. In combination with transgenic IL36A exacerbates skin abnormalities (acanthosis, hyperkeratosis, presence of a mixed inflammatory cell infiltrate and increased cytokine and chemokine expression). Bioactive (processed) recombinant IL36RN inhibits effects of IL-36 when used in 100- 1000-fold molar excess. Belongs to the IL-1 family. Sequence=CAB59831.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of cytokine-mediated signaling pathway immune system process cytokine activity interleukin-1 receptor binding interleukin-1 receptor antagonist activity extracellular region extracellular space inflammatory response immune response cytokine-mediated signaling pathway antifungal humoral response neutrophil chemotaxis negative regulation of interleukin-17 production negative regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of JNK cascade cellular response to lipopolysaccharide negative regulation of interferon-gamma secretion uc008ios.1 uc008ios.2 uc008ios.3 uc008ios.4 
ENSMUST00000028361.5 Il36a ENSMUST00000028361.5 interleukin 36A (from RefSeq NM_019450.3) ENSMUST00000028361.1 ENSMUST00000028361.2 ENSMUST00000028361.3 ENSMUST00000028361.4 Fil1e IL36A_MOUSE Il1e Il1f6 Il1h1 Il36a NM_019450 Q9JLA2 uc008ioq.1 uc008ioq.2 uc008ioq.3 Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL- 36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of pro- inflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes. May play a role in pro-inflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c(+) alveolar macrophages. May be involved in T-cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c(+) cells. May be involved in CD4(+) T-cell proliferation. Induces NF-kappa B activation in macrophages. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) and thereby secretion. Cytoplasm Secreted Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. Highly expressed in embryonic tissue and in tissues containing epithelial cells. Elevated expression levels are detected in chronic kidney disease; expressed inepithelia from the distal convoluted tubules (DCTs) to the cortical collecting ducts (CCDs) in single nephrons (at protein level). By IL-22 in normal and psoriasis-like skin. N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). Belongs to the IL-1 family. positive regulation of cytokine production immune system process cytokine activity interleukin-1 receptor binding extracellular region extracellular space inflammatory response immune response cytokine-mediated signaling pathway neutrophil chemotaxis positive regulation of interleukin-6 production positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of JNK cascade cellular response to lipopolysaccharide uc008ioq.1 uc008ioq.2 uc008ioq.3 
ENSMUST00000028362.9 Ly75 ENSMUST00000028362.9 lymphocyte antigen 75 (from RefSeq NM_013825.4) B2RWW5 Cd205 ENSMUST00000028362.1 ENSMUST00000028362.2 ENSMUST00000028362.3 ENSMUST00000028362.4 ENSMUST00000028362.5 ENSMUST00000028362.6 ENSMUST00000028362.7 ENSMUST00000028362.8 LY75_MOUSE NM_013825 Q60767 Q8C7T3 Q91XL8 Q9QUZ6 uc008jud.1 uc008jud.2 Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B lymphocytes (By similarity). Membrane ; Single- pass type I membrane protein Expressed in dendritic and thymic epithelial cells and lymph nodes. N-glycosylated. Name=Functional Glycomics Gateway - Glycan Binding; Note=DEC-205; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_180"; transmembrane signaling receptor activity endocytosis external side of plasma membrane membrane integral component of membrane carbohydrate binding uc008jud.1 uc008jud.2 
ENSMUST00000028363.2 Il36b ENSMUST00000028363.2 interleukin 36B (from RefSeq NM_027163.4) ENSMUST00000028363.1 Fil1e IL36B_MOUSE Il1f8 Il36b NM_027163 Q8R461 Q9D6Z6 uc008ion.1 uc008ion.2 uc008ion.3 Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL- 36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta- defensin 103 as well as a number of matrix metalloproteases (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of pro-inflammatory cytokines in bone marrow- derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF- alpha and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T-helper 1 (Th1) cells, cultured CD4(+) T- cells and splenocytes. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Cytoplasm Secreted Note=Secreted upon LPS treatment followed by ATP-induced activation of P2rx7. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (By similarity). N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). Belongs to the IL-1 family. Sequence=AAL67152.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; positive regulation of cytokine production immune system process cytokine activity interleukin-1 receptor binding extracellular region extracellular space inflammatory response immune response cytokine-mediated signaling pathway neutrophil chemotaxis positive regulation of interleukin-6 production positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of T cell differentiation positive regulation of JNK cascade cellular response to lipopolysaccharide uc008ion.1 uc008ion.2 uc008ion.3 
ENSMUST00000028368.14 Wdsub1 ENSMUST00000028368.14 WD repeat, SAM and U-box domain containing 1, transcript variant 1 (from RefSeq NM_028118.2) ENSMUST00000028368.1 ENSMUST00000028368.10 ENSMUST00000028368.11 ENSMUST00000028368.12 ENSMUST00000028368.13 ENSMUST00000028368.2 ENSMUST00000028368.3 ENSMUST00000028368.4 ENSMUST00000028368.5 ENSMUST00000028368.6 ENSMUST00000028368.7 ENSMUST00000028368.8 ENSMUST00000028368.9 NM_028118 Q80X63 Q9D0I6 WSDU1_MOUSE uc008jto.1 uc008jto.2 uc008jto.3 uc008jto.4 uc008jto.5 Sequence=AAH50792.1; Type=Erroneous initiation; Evidence=; molecular_function ubiquitin-protein transferase activity cellular_component biological_process protein ubiquitination uc008jto.1 uc008jto.2 uc008jto.3 uc008jto.4 uc008jto.5 
ENSMUST00000028369.6 Dapl1 ENSMUST00000028369.6 death associated protein-like 1 (from RefSeq NM_029723.3) DAPL1_MOUSE ENSMUST00000028369.1 ENSMUST00000028369.2 ENSMUST00000028369.3 ENSMUST00000028369.4 ENSMUST00000028369.5 Eeda NM_029723 Q9D757 uc008jti.1 uc008jti.2 uc008jti.3 uc008jti.4 May play a role in the early stages of epithelial differentiation or in apoptosis. Expressed in hair follicle, corneal epithelium, epidermis and footpad epithelium (at protein level). Weakly expressed in outer cells of the two cell- layer ectoderm at embryonic day 14.5. Detected only in the intermediate cells, undetectable in the basal or outermost epidermal cells or the occasional follicular buds. In 17.5 dpc and 18.5 dpc epidermis expression is restricted to a single layer of suprabasal cells and is absent in the granular cell layer. Also present in the differentiated follicular cells at the apex of the 'horseshoeshaped' matrix. Detected throughout the limbal and corneal epithelium at day 1 of postnatal life, at day 5 of post-natal life it was no longer detected in the limbal epithelium. cellular_component apoptotic process negative regulation of autophagy cell differentiation cellular response to amino acid starvation death domain binding apoptotic signaling pathway uc008jti.1 uc008jti.2 uc008jti.3 uc008jti.4 
ENSMUST00000028378.4 Galnt3 ENSMUST00000028378.4 polypeptide N-acetylgalactosaminyltransferase 3 (from RefSeq NM_015736.2) ENSMUST00000028378.1 ENSMUST00000028378.2 ENSMUST00000028378.3 GALT3_MOUSE NM_015736 P70419 Q3UXL2 Q80V55 uc008jwu.1 uc008jwu.2 uc008jwu.3 uc008jwu.4 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:8912633). Has activity toward HIV envelope glycoprotein gp120 (By similarity). Has activity towards EA2, MUC2 and MUC5 (PubMed:8912633). Probably glycosylates fibronectin in vivo (By similarity). Glycosylates FGF23 (By similarity). Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Evidence=; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Note=Resides preferentially in the trans and medial parts of the Golgi stack. Highly expressed in the reproductive tract, principally in the testis and uterus, and to a lesser degree in the cervix with only trace levels in the ovary. Also expressed at high level in sublingual gland, stomach and colon, with more moderate amounts present in the submandibular and parotid gland as well as the kidney. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity). Essential for glycosylation of FGF23 (By similarity). Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Name=Functional Glycomics Gateway - GTase; Note=Polypeptide N-acetylgalactosaminyltransferase 3; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_512"; polypeptide N-acetylgalactosaminyltransferase activity calcium ion binding Golgi apparatus protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via serine protein O-linked glycosylation via threonine manganese ion binding carbohydrate binding Golgi cisterna membrane metal ion binding perinuclear region of cytoplasm uc008jwu.1 uc008jwu.2 uc008jwu.3 uc008jwu.4 
ENSMUST00000028382.13 Nup35 ENSMUST00000028382.13 nucleoporin 35, transcript variant 1 (from RefSeq NM_027091.4) A2ATJ3 ENSMUST00000028382.1 ENSMUST00000028382.10 ENSMUST00000028382.11 ENSMUST00000028382.12 ENSMUST00000028382.2 ENSMUST00000028382.3 ENSMUST00000028382.4 ENSMUST00000028382.5 ENSMUST00000028382.6 ENSMUST00000028382.7 ENSMUST00000028382.8 ENSMUST00000028382.9 Mp44 NM_027091 NUP35_MOUSE Nup53 Q8R4R6 Q9D7J2 uc008khs.1 uc008khs.2 uc008khs.3 uc008khs.4 Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC (By similarity). Interacts with TMEM48/NDC1. Forms a complex with NUP93, NUP155, NUP205 and lamin B; The interaction with NUP93 is direct. Nucleus, nuclear pore complex Nucleus membrane ; Peripheral membrane protein Note=Tightly associated with the nuclear membrane and lamina. Belongs to the Nup35 family. nucleic acid binding single-stranded DNA binding phospholipid binding nucleus nuclear pore nuclear lamina nucleoplasm plasma membrane NLS-bearing protein import into nucleus nucleocytoplasmic transport nuclear pore organization protein transport membrane structural constituent of nuclear pore nuclear membrane protein homodimerization activity nuclear pore central transport channel nuclear pore nuclear basket mRNA transport cellular response to leukemia inhibitory factor uc008khs.1 uc008khs.2 uc008khs.3 uc008khs.4 
ENSMUST00000028384.5 Dusp19 ENSMUST00000028384.5 dual specificity phosphatase 19 (from RefSeq NM_024438.4) Dusp19 ENSMUST00000028384.1 ENSMUST00000028384.2 ENSMUST00000028384.3 ENSMUST00000028384.4 NM_024438 Q99N12 Q99N12_MOUSE uc008kho.1 uc008kho.2 uc008kho.3 Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation phosphatase activity uc008kho.1 uc008kho.2 uc008kho.3 
ENSMUST00000028386.12 Nckap1 ENSMUST00000028386.12 NCK-associated protein 1, transcript variant 2 (from RefSeq NM_016965.3) ENSMUST00000028386.1 ENSMUST00000028386.10 ENSMUST00000028386.11 ENSMUST00000028386.2 ENSMUST00000028386.3 ENSMUST00000028386.4 ENSMUST00000028386.5 ENSMUST00000028386.6 ENSMUST00000028386.7 ENSMUST00000028386.8 ENSMUST00000028386.9 Hem2 Kiaa0587 NCKP1_MOUSE NM_016965 Nap1 P28660 Q3UPY6 Q80TX0 Q8CG49 Q99KY0 uc008khm.1 uc008khm.2 uc008khm.3 uc008khm.4 Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705). Associates preferentially with the first SH3 domain of NCK (By similarity). Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Interacts with NYAP1, NYAP2 and MYO16. P28660; Q5DU14: Myo16; NbExp=2; IntAct=EBI-771576, EBI-7448308; Cell membrane ; Single-pass membrane protein ; Cytoplasmic side Cell projection, lamellipodium membrane ; Single-pass membrane protein ; Cytoplasmic side Cytoplasm Note=At the interface between the lamellipodial actin meshwork and the membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P28660-1; Sequence=Displayed; Name=2; IsoId=P28660-2; Sequence=VSP_016261, VSP_016262; High expression in cerebral cortex, not in cerebellar cortex. Belongs to the HEM-1/HEM-2 family. Sequence=BAC65600.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cell morphogenesis in utero embryonic development ruffle somitogenesis neural tube closure protein binding cytoplasm plasma membrane zygotic determination of anterior/posterior axis, embryo endoderm development mesodermal cell migration embryonic body morphogenesis positive regulation of lamellipodium assembly membrane integral component of membrane cell migration Rac protein signal transduction lamellipodium cell projection assembly lamellipodium assembly positive regulation of actin filament polymerization cortical actin cytoskeleton organization notochord development establishment or maintenance of actin cytoskeleton polarity SCAR complex lamellipodium membrane filamentous actin regulation of protein localization embryonic heart tube development cell migration involved in gastrulation cell projection basal protein localization apical protein localization paraxial mesoderm development paraxial mesoderm morphogenesis notochord morphogenesis embryonic foregut morphogenesis neuron projection morphogenesis protein stabilization postsynapse positive regulation of Arp2/3 complex-mediated actin nucleation Rac GTPase binding uc008khm.1 uc008khm.2 uc008khm.3 uc008khm.4 
ENSMUST00000028389.4 Frzb ENSMUST00000028389.4 frizzled-related protein (from RefSeq NM_011356.4) ENSMUST00000028389.1 ENSMUST00000028389.2 ENSMUST00000028389.3 Fiz Fre Frzb1 NM_011356 O09075 O09093 P97401 Q91W58 SFRP3_MOUSE Sfrp3 uc008khl.1 uc008khl.2 uc008khl.3 Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity). Interacts with MYOC. Secreted Expressed in kidney, brain, testis. Weak expression in spleen and heart. In early gastrulation, expressed in all three germ layers. In later embryogenesis, expressed in a range of tissues including the central and peripheral nervous systems and the nephogenic mesenchyme. The FZ domain is involved in binding with Wnt ligands. Belongs to the secreted frizzled-related protein (sFRP) family. protein binding extracellular region extracellular space cytoplasm multicellular organism development negative regulation of cell proliferation negative regulation of cell development neural crest cell differentiation Wnt signaling pathway Wnt-protein binding cell differentiation negative regulation of Wnt signaling pathway negative regulation of cell growth non-canonical Wnt signaling pathway inner ear morphogenesis positive regulation of apoptotic process positive regulation of fat cell differentiation convergent extension involved in organogenesis canonical Wnt signaling pathway negative regulation of cartilage development somite development negative regulation of hepatocyte differentiation negative regulation of canonical Wnt signaling pathway cochlea morphogenesis uc008khl.1 uc008khl.2 uc008khl.3 
ENSMUST00000028392.8 Dnajc10 ENSMUST00000028392.8 DnaJ heat shock protein family (Hsp40) member C10 (from RefSeq NM_024181.2) A2ASA2 DJC10_MOUSE ENSMUST00000028392.1 ENSMUST00000028392.2 ENSMUST00000028392.3 ENSMUST00000028392.4 ENSMUST00000028392.5 ENSMUST00000028392.6 ENSMUST00000028392.7 Erdj5 Jpdi NM_024181 Q71S84 Q8CH78 Q8CIB0 Q99LV4 Q9DC23 uc008khj.1 uc008khj.2 uc008khj.3 Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. Interacts with HSPA5 (via its J domain). Interacts with EDEM1. Endoplasmic reticulum lumen Ubiquitous. Particularly abundant in secretory tissues. Ubiquitous in fetal tissues and tumor tissues. Higher expression in fetal tissues than in adult tissues. Expressed in testis, pancreas, fetal thymus and fetal kidney. High expression in heart, liver, kidney, and testis. Low expression in spleen and skeletal muscle. Thioredoxin domains 3 and 4 are the primary reductase domains. The thioredoxin-like regions Trxb 1 and 2 lack a redox-active CXXC motif. Mice are viable and healthy but show enhanced endoplasmic reticulum stress response in the salivary gland. ATPase activator activity negative regulation of protein phosphorylation protein binding endoplasmic reticulum endoplasmic reticulum lumen protein disulfide oxidoreductase activity disulfide oxidoreductase activity oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor ER-associated ubiquitin-dependent protein catabolic process Hsp70 protein binding positive regulation of ATPase activity endoplasmic reticulum chaperone complex protein folding in endoplasmic reticulum response to endoplasmic reticulum stress cell redox homeostasis chaperone binding ATPase binding misfolded protein binding oxidation-reduction process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress uc008khj.1 uc008khj.2 uc008khj.3 
ENSMUST00000028398.14 Ube2e3 ENSMUST00000028398.14 ubiquitin-conjugating enzyme E2E 3, transcript variant 15 (from RefSeq NR_185266.1) ENSMUST00000028398.1 ENSMUST00000028398.10 ENSMUST00000028398.11 ENSMUST00000028398.12 ENSMUST00000028398.13 ENSMUST00000028398.2 ENSMUST00000028398.3 ENSMUST00000028398.4 ENSMUST00000028398.5 ENSMUST00000028398.6 ENSMUST00000028398.7 ENSMUST00000028398.8 ENSMUST00000028398.9 NR_185266 O09180 P52483 Q3TI00 Q91X63 UB2E3_MOUSE Ubce4 Ubcm2 uc008kgn.1 uc008kgn.2 uc008kgn.3 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination (By similarity). Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence= Protein modification; protein ubiquitination. Interacts with NEDD4L. The ubiquitin-loaded form interacts specifically with importin-11 (IPO11), leading to its import into the nucleus. Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner. Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding ubiquitin-protein transferase activity ATP binding nucleus cytoplasm protein ubiquitination transferase activity regulation of growth ubiquitin conjugating enzyme activity protein K63-linked ubiquitination protein K48-linked ubiquitination protein K11-linked ubiquitination uc008kgn.1 uc008kgn.2 uc008kgn.3 
ENSMUST00000028403.3 Cybrd1 ENSMUST00000028403.3 cytochrome b reductase 1 (from RefSeq NM_028593.2) A2AUU8 CYBR1_MOUSE Cybrd1 Dcytb ENSMUST00000028403.1 ENSMUST00000028403.2 NM_028593 Q925G2 Q9D7U1 uc008kaf.1 uc008kaf.2 uc008kaf.3 uc008kaf.4 Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:17068337). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes (PubMed:11230685, PubMed:12547225). It is also able to reduce extracellular monodehydro- L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed:17068337). May also act as a ferrireductase in airway epithelial cells (By similarity). May also function as a cupric transmembrane reductase (PubMed:18498772). Reaction=Fe(3+)(out) + L-ascorbate(in) = Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in); Xref=Rhea:RHEA:30403, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:38290, ChEBI:CHEBI:59513; EC=7.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30404; Evidence=; Reaction=Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in); Xref=Rhea:RHEA:66656, ChEBI:CHEBI:15378, ChEBI:CHEBI:29036, ChEBI:CHEBI:38290, ChEBI:CHEBI:49552, ChEBI:CHEBI:59513; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66657; Evidence=; Reaction=L-ascorbate(in) + monodehydro-L-ascorbate radical(out) = L- ascorbate(out) + monodehydro-L-ascorbate radical(in); Xref=Rhea:RHEA:66524, ChEBI:CHEBI:38290, ChEBI:CHEBI:59513; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66525; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 2 heme b groups non-covalently. ; Homodimer. Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Note=Localized at the brush border of duodenal cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q925G2-1; Sequence=Displayed; Name=2; IsoId=Q925G2-2; Sequence=VSP_030396, VSP_030397; Highly expressed in the brush-border membrane of duodenal enterocytes (at protein level). Also expressed in liver and spleen. By iron deficiency. Up-regulated in duodenal mucosa of mice lacking transferrin or Hfe (at protein level). Mice are normal and do not display iron stores defects, even in the setting of iron deficiency. These results, reported by PubMed:15961514, suggest that Cybrd1 is not an essential component of intestinal iron apparatus. However, according to PubMed:16326980, no direct measurements of iron absorption were made by PubMed:15961514, suggesting that final conclusions can be drawn only when direct iron absorption studies are carried out or mice are maintained on a diet containing ferric iron only. ferric-chelate reductase activity lysosomal membrane response to iron ion membrane integral component of membrane oxidoreductase activity brush border membrane metal ion binding oxidation-reduction process uc008kaf.1 uc008kaf.2 uc008kaf.3 uc008kaf.4 
ENSMUST00000028408.3 Hat1 ENSMUST00000028408.3 histone aminotransferase 1 (from RefSeq NM_026115.4) ENSMUST00000028408.1 ENSMUST00000028408.2 HAT1_MOUSE NM_026115 Q8BY71 uc008kaq.1 uc008kaq.2 Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:23754951). Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). Drives H4 production by chromatin binding to support chromatin replication and acetylation (PubMed:23754951). Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression. Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23754951). In addition, acetylates other substrates such as chromatin-related proteins. Acetylates also RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (By similarity). Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones. Component of the histone H3.1 and H3.3 complexes. Nucleus matrix Mitochondrion Phosphorylated by AMPK at Ser-187; phosphorylation increases HAT1 activity. Homozygous deletion of HAT1 results in neonatal lethality but survival to at least late embryogenesis. The structure of the vertebrae in the neonates degenerates near the base of the spinal column. Belongs to the HAT1 family. chromosome, telomeric region nuclear chromatin histone acetyltransferase activity nucleus nucleoplasm chromatin organization DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly chromatin silencing at telomere response to nutrient H4 histone acetyltransferase activity nuclear matrix histone acetylation transferase activity transferase activity, transferring acyl groups macromolecular complex histone binding intracellular membrane-bounded organelle histone H4 acetylation uc008kaq.1 uc008kaq.2 
ENSMUST00000028410.4 Xirp2 ENSMUST00000028410.4 xin actin-binding repeat containing 2, transcript variant 1 (from RefSeq NM_001024618.2) A1ECA5 A2AVA2 Cmya3 ENSMUST00000028410.1 ENSMUST00000028410.2 ENSMUST00000028410.3 NM_001024618 Q4U4S6 Q5S4P6 Q5S4P7 Q5S4P8 Q8BS23 XIRP2_MOUSE Xin2 uc008jxk.1 uc008jxk.2 Protects actin filaments from depolymerization. Interacts with ACTN2. Interacts with F-actin (By similarity). Q4U4S6; Q61762: Kcna5; NbExp=2; IntAct=EBI-10768169, EBI-26520959; Q4U4S6; Q9JJV9: Scn5a; NbExp=2; IntAct=EBI-10768169, EBI-8313814; Cell junction Note=Colocalizes with actin stress fibers. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q4U4S6-1; Sequence=Displayed; Name=2; IsoId=Q4U4S6-2; Sequence=VSP_030849, VSP_030850; Expression is restricted to heart and skeletal muscle. Present in intercalated disks of the heart and in the Z-disk region of skeletal muscle (at protein level). By MEF2A in skeletal muscle. By angiotensin II in heart. Xin repeats bind F-actin. Belongs to the Xin family. stress fiber ventricular septum development actin binding protein binding focal adhesion heart development Z disc actin cytoskeleton organization cell junction cell-cell junction organization metal ion binding actin filament binding alpha-actinin binding cardiac muscle tissue morphogenesis uc008jxk.1 uc008jxk.2 
ENSMUST00000028426.9 Cers6 ENSMUST00000028426.9 ceramide synthase 6, transcript variant 2 (from RefSeq NM_172856.5) CERS6_MOUSE Cers6 ENSMUST00000028426.1 ENSMUST00000028426.2 ENSMUST00000028426.3 ENSMUST00000028426.4 ENSMUST00000028426.5 ENSMUST00000028426.6 ENSMUST00000028426.7 ENSMUST00000028426.8 Lass6 NM_172856 Q3U817 Q8BV12 Q8C172 uc008jxs.1 uc008jxs.2 uc008jxs.3 Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:15823095, PubMed:18541923, PubMed:23760501, PubMed:31150623). Can use other acyl donors, but with less efficiency (PubMed:18541923). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Ceramides generated by CERS6 play a role in inflammatory response (PubMed:22544924). Acts as a regulator of metabolism and hepatic lipid accumulation (PubMed:25295788, PubMed:30655217, PubMed:31150623). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (PubMed:31150623). Reaction=a sphingoid base + hexadecanoyl-CoA = an N-hexadecanoyl- sphingoid base + CoA + H(+); Xref=Rhea:RHEA:61472, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:84410, ChEBI:CHEBI:144703; EC=2.3.1.291; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61473; Evidence= Reaction=hexadecanoyl-CoA + sphinganine = CoA + H(+) + N- hexadecanoylsphinganine; Xref=Rhea:RHEA:36539, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57817, ChEBI:CHEBI:67042; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36540; Evidence= Reaction=hexadecanoyl-CoA + hexadecasphinganine = CoA + H(+) + N- hexadecanoylhexadecasphinganine; Xref=Rhea:RHEA:43040, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:71009, ChEBI:CHEBI:82810; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43041; Evidence=; Reaction=hexadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N- hexadecanoylsphing-4-enine; Xref=Rhea:RHEA:36687, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57756, ChEBI:CHEBI:72959; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36688; Evidence=; Reaction=sphinganine + tetradecanoyl-CoA = CoA + H(+) + N- (tetradecanoyl)-sphinganine; Xref=Rhea:RHEA:36571, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:57817, ChEBI:CHEBI:67045; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36572; Evidence=; Reaction=octadecanoyl-CoA + sphinganine = CoA + H(+) + N- (octadecanoyl)-sphinganine; Xref=Rhea:RHEA:36547, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57817, ChEBI:CHEBI:67033; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36548; Evidence=; Lipid metabolism; sphingolipid metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Broadly expressed, with highest levels in kidney and brain (at protein level). Up-regulated in liver in response to high-fat diet. N-glycosylated (PubMed:15823095, PubMed:23760501). Glycosylation on Asn-18 is not necessary for function (PubMed:15823095). Acetylated (PubMed:26620563). Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation (PubMed:26620563). Phosphorylated at the C-terminus by CK2. Mice show behavioral abnormalities including a clasping abnormality of their hind limbs and a habituation deficit (PubMed:23760501). Knockout mice are protected against high fat diet- induced obesity and glucose intolerance (PubMed:25295788, PubMed:31150623). Mice show decreased palmitoyl (C16:0) ceramide pools and increased energy expenditure (PubMed:25295788, PubMed:31150623). Conditional deletion in brown adipose tissue or liver also protects mice against high fat diet-induced obesity, while it is not the case with specific deletion in myeloid cells (PubMed:25295788). Some prediction bioinformatics tools predict the presence of a homeobox domain (By similarity). However, the domain is degenerate and residues that are important for DNA-binding are absent (By similarity). Moreover, the protein localizes in the endoplasmic reticulum and not in the nucleus, strongly suggesting that it does not constitute a canonical homeobox domain (PubMed:15823095). DNA binding protein binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process sphingolipid metabolic process inflammatory response membrane integral component of membrane transferase activity sphingolipid biosynthetic process ceramide biosynthetic process sphingosine N-acyltransferase activity uc008jxs.1 uc008jxs.2 uc008jxs.3 
ENSMUST00000028430.6 Cyct ENSMUST00000028430.6 cytochrome c, testis (from RefSeq NM_009989.3) CYC2_MOUSE ENSMUST00000028430.1 ENSMUST00000028430.2 ENSMUST00000028430.3 ENSMUST00000028430.4 ENSMUST00000028430.5 NM_009989 P00015 uc008key.1 uc008key.2 uc008key.3 uc008key.4 Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity). Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane. This is one of two isocytochromes C found in the testis. The other is identical with the form found in other mouse tissues. These cytochromes are assumed to be located in the sperm. Binds 1 heme c group covalently per subunit. Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration. Belongs to the cytochrome c family. Name=Protein Spotlight; Note=Life shuttle - Issue 76 of November 2006; URL="https://web.expasy.org/spotlight/back_issues/076"; mitochondrion mitochondrial intermembrane space mitochondrial electron transport, ubiquinol to cytochrome c mitochondrial electron transport, cytochrome c to oxygen apoptotic process electron carrier activity heme binding hydrogen peroxide metabolic process metal ion binding oxidation-reduction process respiratory chain positive regulation of intrinsic apoptotic signaling pathway uc008key.1 uc008key.2 uc008key.3 uc008key.4 
ENSMUST00000028465.14 P2rx3 ENSMUST00000028465.14 purinergic receptor P2X, ligand-gated ion channel, 3 (from RefSeq NM_145526.3) A2AW02 ENSMUST00000028465.1 ENSMUST00000028465.10 ENSMUST00000028465.11 ENSMUST00000028465.12 ENSMUST00000028465.13 ENSMUST00000028465.2 ENSMUST00000028465.3 ENSMUST00000028465.4 ENSMUST00000028465.5 ENSMUST00000028465.6 ENSMUST00000028465.7 ENSMUST00000028465.8 ENSMUST00000028465.9 NM_145526 P2RX3_MOUSE Q3UR32 Q8R1U4 uc008kjr.1 uc008kjr.2 uc008kjr.3 Receptor for ATP that acts as a ligand-gated cation channel (By similarity). Plays a role in sensory perception (PubMed:15961431, PubMed:16322458). Required for normal perception of pain (PubMed:15961431). Required for normal taste perception (PubMed:16322458). Homotrimer (By similarity). Functional P2XRs are organized as homomeric and heteromeric trimers (By similarity). Cell membrane ; Multi-pass membrane protein Simultaneous knockout of P2rx2 and P2rx3 results in reduced pain-related behaviors in response to intraplantar injection of formalin and reduced urinary bladder reflexes and decreased pelvic afferent nerve activity in response to bladder distension. Neurons have minimal to no response to ATP (PubMed:15961431). Simultaneous knockout of P2rx2 and P2rx3 results in defects in taste responses in the taste nerves and reduced behavioral responses to sweeteners, glutamate and bitter substances (PubMed:16322458). Belongs to the P2X receptor family. nucleotide binding purinergic nucleotide receptor activity response to hypoxia extracellular ATP-gated cation channel activity ion channel activity ATP binding integral component of nuclear inner membrane rough endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane ion transport cation transport chemical synaptic transmission neuromuscular synaptic transmission response to temperature stimulus response to heat response to cold response to mechanical stimulus response to carbohydrate response to organic substance urinary bladder smooth muscle contraction monovalent inorganic cation transport membrane integral component of membrane neuronal action potential axon peristalsis response to ATP purinergic nucleotide receptor signaling pathway neuron projection neuronal cell body terminal bouton dendritic spine receptor complex membrane raft regulation of synaptic plasticity behavioral response to pain modulation of synaptic transmission sensory perception of taste protein homooligomerization excitatory postsynaptic potential behavioral response to formalin induced pain protein homotrimerization cellular response to ATP cation transmembrane transport integral component of presynaptic membrane positive regulation of sensory perception of pain uc008kjr.1 uc008kjr.2 uc008kjr.3 
ENSMUST00000028466.12 Prg3 ENSMUST00000028466.12 proteoglycan 3 (from RefSeq NM_016914.2) A2AW01 ENSMUST00000028466.1 ENSMUST00000028466.10 ENSMUST00000028466.11 ENSMUST00000028466.2 ENSMUST00000028466.3 ENSMUST00000028466.4 ENSMUST00000028466.5 ENSMUST00000028466.6 ENSMUST00000028466.7 ENSMUST00000028466.8 ENSMUST00000028466.9 Mbp2 NM_016914 PRG3_MOUSE Prg3 Q3SXA9 Q9JL95 uc008kjq.1 uc008kjq.2 Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. Note=Localized to the eosinophil secondary granule. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q9JL95-1; Sequence=Displayed; Name=2; IsoId=Q9JL95-3; Sequence=VSP_034564; Expressed in bone marrow, spleen, and thymus. Not detected in heart, liver or lung. Sequence=AAI04390.2; Type=Frameshift; Evidence=; Name=Functional Glycomics Gateway - Glycan Binding; Note=Eosinophil major basic protein homolog; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_152"; histamine biosynthetic process immune response negative regulation of translation leukotriene biosynthetic process carbohydrate binding neutrophil activation superoxide anion generation positive regulation of interleukin-8 biosynthetic process basophil activation uc008kjq.1 uc008kjq.2 
ENSMUST00000028467.6 Prg2 ENSMUST00000028467.6 proteoglycan 2, bone marrow (from RefSeq NM_008920.4) ENSMUST00000028467.1 ENSMUST00000028467.2 ENSMUST00000028467.3 ENSMUST00000028467.4 ENSMUST00000028467.5 Mbp-1 NM_008920 PRG2_MOUSE Q61878 uc008kjp.1 uc008kjp.2 Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity). Secreted Nitrated. Name=Functional Glycomics Gateway - Glycan Binding; Note=Eosinophil major basic protein; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_151"; defense response to nematode immune system process immune response extracellular matrix structural constituent conferring compression resistance carbohydrate binding negative regulation of interleukin-10 production positive regulation of interleukin-4 production defense response to bacterium uc008kjp.1 uc008kjp.2 
ENSMUST00000028470.10 Timm10 ENSMUST00000028470.10 translocase of inner mitochondrial membrane 10 (from RefSeq NM_013899.2) ENSMUST00000028470.1 ENSMUST00000028470.2 ENSMUST00000028470.3 ENSMUST00000028470.4 ENSMUST00000028470.5 ENSMUST00000028470.6 ENSMUST00000028470.7 ENSMUST00000028470.8 ENSMUST00000028470.9 NM_013899 P62073 Q9WV99 Q9WVA0 Q9Y5J8 TIM10_MOUSE Tim10 uc008kjh.1 uc008kjh.2 uc008kjh.3 uc008kjh.4 Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6- bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). Belongs to the small Tim family. mitochondrion mitochondrial inner membrane protein transport membrane mitochondrial intermembrane space protein transporter complex protein homodimerization activity protein import into mitochondrial inner membrane metal ion binding chaperone binding chaperone-mediated protein transport uc008kjh.1 uc008kjh.2 uc008kjh.3 uc008kjh.4 
ENSMUST00000028471.6 Smtnl1 ENSMUST00000028471.6 smoothelin-like 1 (from RefSeq NM_024230.2) ENSMUST00000028471.1 ENSMUST00000028471.2 ENSMUST00000028471.3 ENSMUST00000028471.4 ENSMUST00000028471.5 NM_024230 Q99LM3 SMTL1_MOUSE uc008kjg.1 uc008kjg.2 Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-301 reduces this inhibitory activity. Interacts with PPP1R12A. Q99LM3; P04268: TPM1; Xeno; NbExp=3; IntAct=EBI-8073484, EBI-8073544; Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. Nucleus. Note=Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm. Phosphorylation at Ser-301 promotes translocation to the nucleus. Widely expressed, with highest expression in skeletal muscles (at protein level). Within striated muscles, significantly more expressed in soleus muscle compared with plantaris muscle or white vastus (at protein level). 30-40% lower expression in females than in males (at protein level). Expressed in type 2a fibers, but not detected in fast twitch type 2b muscle white vastus nor in oxidative type I/b heart muscle (at protein level). Expressed within myometrial cells of the uterus, as well as in the endometrial layer. In the aorta, confined to smooth muscle cells. Not detected in endothelial cells. Not detected in somites which give rise to skeletal muscle at 10.5 dpc (at protein level). Expressed in skeletal muscle of the tongue, diaphragm and axial muscles from 14.5 through 17.5 dpc (at protein level). Not detected in limb buds (at protein level). Overall increase by up to 10-12-fold in vascular and uterine smooth muscle during pregnancy (at protein level). At day 13 of pregnancy, expression increases in striated muscle by 2.5-fold compared with non-pregnant mice, and by about 2-fold over levels expressed in males (at protein level). At the same time, dramatically increased in myometrial cells of the uterus, in the endometrial layer and in aortal smooth muscle. Steadily declines through parturition and the onset of lactation (at protein level). Significantly reduced by exercise in smooth and in skeletal muscles. Maximal phosphorylation of Ser-301 correlates with maximal relaxation of aorta in response to acetylcholine. Male mutant mice perform better than wild type in exercise stress test after endurance training. Females do not differ significantly during these tests. Even in the absence of endurance exercise, mutant mice exhibit muscle fiber adaptation, i.e. more type 2a fibers and lower levels of type 1b fibers. Endothelium-dependent vasorelaxation of the aorta is enhanced and responses to beta- adrenergic constriction are reduced. Expression of PPP1R12A is 30-40- fold higher in mutant mice than in wild-type littermates and exhibits a steady decline as the animals become sexually mature (at protein level). During pregnancy, by day 13, PPP1R12A expression is dramatically increased to 6-14 times over the levels observed in pregnant wild-type littermates (at protein level). PPP1R12B expression levels are unaffected. In vascular smooth muscle, force development in response to phenylephrine is reduced and both the rate and extent of relaxation in response to acetylcholine are promoted. Myosin dephosphorylation is promoted in mutant animals. Belongs to the smoothelin family. protein phosphatase inhibitor activity protein binding calmodulin binding tropomyosin binding nucleus cytoplasm microtubule organizing center protein phosphatase 1 binding response to activity myosin phosphatase regulator activity peptidyl-serine phosphorylation actin cytoskeleton organization M band I band filamentous actin negative regulation of phosphoprotein phosphatase activity response to drug contractile fiber protein self-association regulation of phosphoprotein phosphatase activity negative regulation of transcription, DNA-templated positive regulation of vasoconstriction muscle organ morphogenesis CH domain binding disordered domain specific binding uc008kjg.1 uc008kjg.2 
ENSMUST00000028475.9 Clp1 ENSMUST00000028475.9 CLP1, cleavage and polyadenylation factor I subunit, transcript variant 1 (from RefSeq NM_133840.3) CLP1_MOUSE ENSMUST00000028475.1 ENSMUST00000028475.2 ENSMUST00000028475.3 ENSMUST00000028475.4 ENSMUST00000028475.5 ENSMUST00000028475.6 ENSMUST00000028475.7 ENSMUST00000028475.8 NM_133840 Q3TEC7 Q3ULZ9 Q99LI9 uc008kja.1 uc008kja.2 uc008kja.3 Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:23474986, PubMed:24766809). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809). Component of the pre-mRNA cleavage complex II (CF- II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. Reaction=a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+); Xref=Rhea:RHEA:15669, Rhea:RHEA-COMP:13180, Rhea:RHEA-COMP:13184, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:136412, ChEBI:CHEBI:136416, ChEBI:CHEBI:456216; EC=2.7.1.78; Evidence=; Reaction=a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'- monophospho-ribonucleoside-RNA + ADP + H(+); Xref=Rhea:RHEA:54580, Rhea:RHEA-COMP:13935, Rhea:RHEA-COMP:13936, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:138282, ChEBI:CHEBI:138284, ChEBI:CHEBI:456216; EC=2.7.1.78; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Evidence=; Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK. Nucleus Early embryonic lethality. Belongs to the Clp1 family. Clp1 subfamily. nucleotide binding tRNA-intron endonuclease complex ATP binding nucleus nucleoplasm cytosol mRNA cleavage factor complex mRNA polyadenylation tRNA splicing, via endonucleolytic cleavage and ligation mRNA processing tRNA processing kinase activity phosphorylation transferase activity cerebellar cortex development targeting of mRNA for destruction involved in RNA interference mRNA 3'-end processing siRNA loading onto RISC involved in RNA interference ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity polynucleotide 5'-hydroxyl-kinase activity polydeoxyribonucleotide kinase activity ATP-dependent polynucleotide kinase activity ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity uc008kja.1 uc008kja.2 uc008kja.3 
ENSMUST00000028494.9 Phospho2 ENSMUST00000028494.9 phosphatase, orphan 2 (from RefSeq NM_028521.2) A2AR04 ENSMUST00000028494.1 ENSMUST00000028494.2 ENSMUST00000028494.3 ENSMUST00000028494.4 ENSMUST00000028494.5 ENSMUST00000028494.6 ENSMUST00000028494.7 ENSMUST00000028494.8 NM_028521 PHOP2_MOUSE Q3V1M5 Q9D9M5 uc008jyq.1 uc008jyq.2 uc008jyq.3 Phosphatase that has high activity toward pyridoxal 5'- phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate. Reaction=H2O + pyridoxal 5'-phosphate = phosphate + pyridoxal; Xref=Rhea:RHEA:20533, ChEBI:CHEBI:15377, ChEBI:CHEBI:17310, ChEBI:CHEBI:43474, ChEBI:CHEBI:597326; EC=3.1.3.74; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. cellular_component dephosphorylation hydrolase activity phosphatase activity pyridoxal phosphatase activity metal ion binding uc008jyq.1 uc008jyq.2 uc008jyq.3 
ENSMUST00000028499.11 Itgav ENSMUST00000028499.11 integrin alpha V, transcript variant 1 (from RefSeq NM_008402.4) A2AKI6 ENSMUST00000028499.1 ENSMUST00000028499.10 ENSMUST00000028499.2 ENSMUST00000028499.3 ENSMUST00000028499.4 ENSMUST00000028499.5 ENSMUST00000028499.6 ENSMUST00000028499.7 ENSMUST00000028499.8 ENSMUST00000028499.9 ITAV_MOUSE NM_008402 P43406 uc008kid.1 uc008kid.2 uc008kid.3 uc008kid.4 This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: The coding region has been updated to represent a CDS sequence that is better supported by available transcript data and the reference genome sequence. The protein length is unchanged. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U14135.1, BC133682.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF (PubMed:9827803, PubMed:10025398). They recognize the sequence R-G- D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (PubMed:9827803). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (By similarity). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1- ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (By similarity). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (By similarity). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (By similarity). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:10025398, PubMed:25127859). ITGAV:ITGB3 acts as a receptor for CD40LG (By similarity). ITGAV:ITGB3 binds to the Lilrb4a/Gp49b receptor and enhances the Lilrb4a-mediated inhibition of mast cell activation (PubMed:11323698). ITGAV:ITGB3 also suppresses marginal zone B cell antibody production through its interaction with Lilrb4a (PubMed:24935931). Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V (ITGAV) associates with either beta-1 (ITGB1), beta-3 (ITGB3), beta-5 (ITGB5), beta-6 (ITGB6) or beta-8 (ITGB8) (Probable). Interacts with RAB25. Interacts with CIB1 (By similarity). Integrins ITGAV:ITGB3 and ITGAV:ITGB5 interact with FBLN5 (via N-terminus) (PubMed:11805835). ITGAV:ITGB3 and ITGAV:ITGB5 interact with CCN3 (By similarity). ITGAV:ITGB3 interacts with ADGRA2 (By similarity). ITGAV:ITGB3 interacts with FGF2; it is likely that FGF2 can simultaneously bind ITGAV:ITGB3 and FGF receptors (By similarity). ITGAV:ITGB3 is found in a ternary complex with CX3CR1 and CX3CL1. ITGAV:ITGB3 is found in a ternary complex with NRG1 and ERBB3. ITGAV:ITGB3 is found in a ternary complex with FGF1 and FGFR1. ITGAV:ITGB3 is found in a ternary complex with IGF1 and IGF1R (By similarity). ITGAV:ITGB3 interacts with IGF2 (By similarity). ITGAV:ITGB3 and ITGAV:ITGB6 interact with FBN1 (By similarity). ITGAV:ITGB3 interacts with CD9, CD81 and CD151 (via second extracellular domain) (By similarity). ITGAV:ITGB6 interacts with TGFB1 (PubMed:10025398). ITGAV:ITGB3 interacts with PTN. Forms a complex with PTPRZ1 and PTN that stimulates endothelial cell migration through ITGB3 'Tyr-773' phosphorylation (By similarity). Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion Mice expressing a null mutation of the alpha-V subunit gene survive until late in embryonic development and occasionally even to birth. They demonstrate cleft palate, and defective development of CNS and gastrointestinal blood vessels. Belongs to the integrin alpha chain family. angiogenesis blood vessel development vasculogenesis fibronectin binding protease binding receptor binding integrin binding voltage-gated calcium channel activity cytosol plasma membrane focal adhesion inflammatory response cell adhesion cell-matrix adhesion positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway multicellular organism development positive regulation of cell proliferation integrin complex fertilization external side of plasma membrane cell surface negative regulation of macrophage derived foam cell differentiation negative regulation of lipid storage membrane integral component of membrane cell migration fibroblast growth factor binding C-X3-C chemokine binding cell junction cell differentiation positive regulation of cell migration lamellipodium membrane filopodium membrane microvillus membrane cell-substrate adhesion insulin-like growth factor I binding negative regulation of lipid transport detection of molecule of bacterial origin ruffle membrane cell adhesion mediated by integrin positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading integrin alphav-beta3 complex integrin alphav-beta5 complex integrin alphav-beta6 complex integrin alphav-beta8 complex gonad morphogenesis alphav-beta3 integrin-IGF-1-IGF1R complex alphav-beta3 integrin-HMGB1 complex endodermal cell differentiation apolipoprotein A-I-mediated signaling pathway transforming growth factor-beta secretion neuregulin binding T cell activation apoptotic cell clearance endothelial cell migration regulation of bone resorption negative regulation of low-density lipoprotein particle receptor biosynthetic process positive regulation of cell adhesion viral entry into host cell metal ion binding protein heterodimerization activity focal adhesion assembly transforming growth factor beta binding negative regulation of lipoprotein metabolic process regulation of phagocytosis extracellular matrix binding negative chemotaxis release of sequestered calcium ion into cytosol trophoblast giant cell differentiation ERK1 and ERK2 cascade calcium ion transmembrane transport response to nitric oxide extrinsic apoptotic signaling pathway in absence of ligand regulation of transforming growth factor beta activation extracellular matrix protein binding negative regulation of entry of bacterium into host cell negative regulation of extrinsic apoptotic signaling pathway opsonin binding protein kinase C binding uc008kid.1 uc008kid.2 uc008kid.3 uc008kid.4 
ENSMUST00000028509.11 Gorasp2 ENSMUST00000028509.11 golgi reassembly stacking protein 2, transcript variant 1 (from RefSeq NM_027352.4) ENSMUST00000028509.1 ENSMUST00000028509.10 ENSMUST00000028509.2 ENSMUST00000028509.3 ENSMUST00000028509.4 ENSMUST00000028509.5 ENSMUST00000028509.6 ENSMUST00000028509.7 ENSMUST00000028509.8 ENSMUST00000028509.9 GORS2_MOUSE NM_027352 Q3U9D2 Q8CCD0 Q91W68 Q99JX3 uc008jzo.1 uc008jzo.2 uc008jzo.3 uc008jzo.4 Key structural protein of the Golgi apparatus (PubMed:32573693). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:32573693). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:32573693). However, other studies suggest that GORASP2 plays a role in assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (By similarity). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (By similarity). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (PubMed:28617811). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (By similarity). Homodimer. Homooligomer. ER stress induces phosphorylation- dependent monomerization (By similarity). Interacts with BLZF1/Golgin 45 (PubMed:11739401, PubMed:28049725). Identified in a complex with RAB2 and GORASP2 (PubMed:11739401). Interacts with JAM2 and JAM3 (PubMed:28617811). Interacts with members of the p24 cargo receptors. Interacts with CNIH and the cytoplasmic domain of transmembrane TGFA, prior its transit in the trans-Golgi. Interacts with KCTD5 (By similarity). Interacts with TMED2 and TMED3 (By similarity). Interacts with SEC16A in response to ER stress (By similarity). Interacts (via PDZ GRASP-type 1 domain) with core-glycosylated CFTR in response to ER stress (By similarity). Golgi apparatus membrane ; Lipid-anchor Endoplasmic reticulum membrane Golgi apparatus Note=Detected in the intermediate Golgi, membrane-associated. ER stress triggers its relocalization from Golgi to ER membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99JX3-1; Sequence=Displayed; Name=2; IsoId=Q99JX3-2; Sequence=VSP_011301; Detected in lung, heart and testis. Colocalized in a polarized fashion in the acrosome region with JAM3 in round spermatids (at protein level). Myristoylated (By similarity). Myristoylation is essential for the Golgi targeting (By similarity). Palmitoylated. Phosphorylated in mitotic cells. ER stress-induced phosphorylation at Ser-443 induces monomerization and subsequent relocalization from Golgi to ER which is essential for mediating unconventional (ER/Golgi- independent) trafficking of CFTR to the cell membrane. Mutant mice have normal weight at birth, but display growth retardation and lower body weight during postnatal development and in adulthood. Females display normal fertility. Males have normal mating behavior, but are infertile, due to defects in spermiogenesis and acrosome formation. Belongs to the GORASP family. Golgi membrane molecular_function endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus Golgi medial cisterna organelle organization Golgi organization spermatogenesis membrane cell differentiation response to endoplasmic reticulum stress organelle assembly uc008jzo.1 uc008jzo.2 uc008jzo.3 uc008jzo.4 
ENSMUST00000028511.8 Mtx2 ENSMUST00000028511.8 metaxin 2 (from RefSeq NM_016804.4) ENSMUST00000028511.1 ENSMUST00000028511.2 ENSMUST00000028511.3 ENSMUST00000028511.4 ENSMUST00000028511.5 ENSMUST00000028511.6 ENSMUST00000028511.7 MNCb-0780 MTX2_MOUSE NM_016804 O88441 Q3TFR2 uc008kej.1 uc008kej.2 uc008kej.3 uc008kej.4 Involved in transport of proteins into the mitochondrion. Interacts with MTX1/metaxin-1. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex (By similarity). Mitochondrion outer membrane Mitochondrion Belongs to the metaxin family. mitochondrial sorting and assembly machinery complex molecular_function nucleolus mitochondrion mitochondrial outer membrane biological_process protein transport membrane uc008kej.1 uc008kej.2 uc008kej.3 uc008kej.4 
ENSMUST00000028515.4 Chrna1 ENSMUST00000028515.4 cholinergic receptor nicotinic alpha 1 subunit (from RefSeq NM_007389.5) Chrna1 ENSMUST00000028515.1 ENSMUST00000028515.2 ENSMUST00000028515.3 NM_007389 Q05A24 Q05A24_MOUSE uc008kcy.1 uc008kcy.2 uc008kcy.3 uc008kcy.4 This gene encodes an alpha subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The alpha subunit plays a role in substrate binding and channel gating. [provided by RefSeq, Nov 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK029177.1, X03986.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub- subfamily. skeletal muscle contraction transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane acetylcholine-gated channel complex ion transport cation transport neuromuscular synaptic transmission neuromuscular junction development cell surface membrane integral component of membrane neuronal action potential acetylcholine-gated cation-selective channel activity cell junction neuromuscular junction ion transmembrane transport regulation of membrane potential synapse postsynaptic membrane muscle cell cellular homeostasis skeletal muscle tissue growth musculoskeletal movement neuromuscular process regulation of postsynaptic membrane potential excitatory postsynaptic potential neuron cellular homeostasis transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc008kcy.1 uc008kcy.2 uc008kcy.3 uc008kcy.4 
ENSMUST00000028517.13 Ola1 ENSMUST00000028517.13 Obg-like ATPase 1, transcript variant 1 (from RefSeq NM_025942.2) B1AYJ8 B1AYK0 ENSMUST00000028517.1 ENSMUST00000028517.10 ENSMUST00000028517.11 ENSMUST00000028517.12 ENSMUST00000028517.2 ENSMUST00000028517.3 ENSMUST00000028517.4 ENSMUST00000028517.5 ENSMUST00000028517.6 ENSMUST00000028517.7 ENSMUST00000028517.8 ENSMUST00000028517.9 Gtpbp9 NM_025942 OLA1_MOUSE Q9CWE2 Q9CX91 Q9CYC9 Q9CZ30 Q9CZ56 uc008kcg.1 uc008kcg.2 Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Monomer. Cytoplasm Nucleus Nucleus, nucleolus Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZ30-1; Sequence=Displayed; Name=2; IsoId=Q9CZ30-2; Sequence=VSP_002054, VSP_002055; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. nucleotide binding ATP binding GTP binding nucleus nucleolus cytoplasm centrosome cytosol hydrolase activity ATPase activity ribosome binding ribosomal large subunit binding ATP metabolic process metal ion binding uc008kcg.1 uc008kcg.2 
ENSMUST00000028522.10 Itga6 ENSMUST00000028522.10 integrin alpha 6, transcript variant 1 (from RefSeq NM_008397.5) ENSMUST00000028522.1 ENSMUST00000028522.2 ENSMUST00000028522.3 ENSMUST00000028522.4 ENSMUST00000028522.5 ENSMUST00000028522.6 ENSMUST00000028522.7 ENSMUST00000028522.8 ENSMUST00000028522.9 Itga6 NM_008397 Q8CC06 Q8CC06_MOUSE uc008kbc.1 uc008kbc.2 uc008kbc.3 uc008kbc.4 This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 4 to bind laminin and to form the main component of hemidesmosomes, which mediate attachment of epithelia to basement membranes. In mouse, deficiency of this gene is associated with absence of hemidesmosomes, severe skin blistering, and early post-natal death. In humans mutations of this gene are associated with epidermolysis bullosa. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]. Membrane ingle-pass type I membrane protein Belongs to the integrin alpha chain family. cell adhesion integrin-mediated signaling pathway integrin complex membrane integral component of membrane uc008kbc.1 uc008kbc.2 uc008kbc.3 uc008kbc.4 
ENSMUST00000028527.8 Kif18a ENSMUST00000028527.8 kinesin family member 18A, transcript variant 1 (from RefSeq NM_139303.2) ENSMUST00000028527.1 ENSMUST00000028527.2 ENSMUST00000028527.3 ENSMUST00000028527.4 ENSMUST00000028527.5 ENSMUST00000028527.6 ENSMUST00000028527.7 KI18A_MOUSE NM_139303 Q3TP77 Q8BLL1 Q91WD7 uc008lmc.1 uc008lmc.2 uc008lmc.3 Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression (By similarity). Interacts with CENPE and ESR1. Cell projection, ruffle Cytoplasm Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Glycosylated. Ubiquitinated. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. mitotic sister chromatid segregation nucleotide binding kinetochore ruffle microtubule motor activity actin binding ATP binding nucleus cytoplasm microtubule organizing center kinetochore microtubule cytoskeleton kinesin complex microtubule caveola microtubule-based movement microtubule depolymerization mitotic metaphase plate congression male meiosis microtubule binding ATP-dependent microtubule motor activity, plus-end-directed protein transport microtubule cytoskeleton ATPase activity cell projection microtubule plus-end binding mitotic spindle astral microtubule tubulin-dependent ATPase activity regulation of microtubule cytoskeleton organization seminiferous tubule development mitotic spindle midzone uc008lmc.1 uc008lmc.2 uc008lmc.3 
ENSMUST00000028533.7 Fshb ENSMUST00000028533.7 follicle stimulating hormone beta (from RefSeq NM_008045.3) ENSMUST00000028533.1 ENSMUST00000028533.2 ENSMUST00000028533.3 ENSMUST00000028533.4 ENSMUST00000028533.5 ENSMUST00000028533.6 FSHB_MOUSE NM_008045 Q60687 uc008llt.1 uc008llt.2 uc008llt.3 uc008llt.4 The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061159.1, AK017593.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:9020850, PubMed:11416011). Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here. Secreted Note=Efficient secretion requires dimerization with CGA. Expressed in the developing pituitary gland at 18.5 dpc. Mice lacking Fshb are viable (PubMed:9020850). Females are infertile displaying abnormal uterus and ovaries that lacked corpora lutea. The infertility is due to impaired follicle maturation which appears before antral follicle formation (PubMed:9020850). Males are fertile and spermatogenesis proceeds normally. However, these mice display a reduced testes size and epididymal sperm count (PubMed:9020850, PubMed:11416011). The number of Sertoli cells is significantly reduced and their ability to support germ cell development is also affected (PubMed:11416011). Belongs to the glycoprotein hormones subunit beta family. ovarian follicle development hormone activity extracellular region extracellular space cytoplasm transforming growth factor beta receptor signaling pathway G-protein coupled receptor signaling pathway hormone-mediated signaling pathway regulation of receptor activity positive regulation of gene expression positive regulation of steroid biosynthetic process follicle-stimulating hormone activity follicle-stimulating hormone complex follicle-stimulating hormone signaling pathway regulation of osteoclast differentiation positive regulation of bone resorption Sertoli cell proliferation uc008llt.1 uc008llt.2 uc008llt.3 uc008llt.4 
ENSMUST00000028536.13 Arl14ep ENSMUST00000028536.13 ADP-ribosylation factor-like 14 effector protein, transcript variant 4 (from RefSeq NM_001362865.1) AL14E_MOUSE Arf7ep ENSMUST00000028536.1 ENSMUST00000028536.10 ENSMUST00000028536.11 ENSMUST00000028536.12 ENSMUST00000028536.2 ENSMUST00000028536.3 ENSMUST00000028536.4 ENSMUST00000028536.5 ENSMUST00000028536.6 ENSMUST00000028536.7 ENSMUST00000028536.8 ENSMUST00000028536.9 NM_001362865 Q7TPE6 Q8BIX3 Q9CZS0 uc008llr.1 uc008llr.2 uc008llr.3 Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. Interacts with ARL14 and MYO1E. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BIX3-1; Sequence=Displayed; Name=2; IsoId=Q8BIX3-2; Sequence=VSP_020776, VSP_020777; [Isoform 2]: May be due to intron retention. molecular_function nucleus nucleolus cytoplasm cytosol plasma membrane focal adhesion biological_process intracellular membrane-bounded organelle uc008llr.1 uc008llr.2 uc008llr.3 
ENSMUST00000028549.14 Slc12a6 ENSMUST00000028549.14 solute carrier family 12, member 6, transcript variant 2 (from RefSeq NM_133649.2) A2AGK1 ENSMUST00000028549.1 ENSMUST00000028549.10 ENSMUST00000028549.11 ENSMUST00000028549.12 ENSMUST00000028549.13 ENSMUST00000028549.2 ENSMUST00000028549.3 ENSMUST00000028549.4 ENSMUST00000028549.5 ENSMUST00000028549.6 ENSMUST00000028549.7 ENSMUST00000028549.8 ENSMUST00000028549.9 Kcc3 NM_133649 Q924N3 Q924N4 S12A6_MOUSE uc008lou.1 uc008lou.2 uc008lou.3 uc008lou.4 [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10347194, PubMed:31649201). May contribute to cell volume homeostasis in single cells (Probable). [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (By similarity). May contribute to cell volume homeostasis in single cells (By similarity). Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out); Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103; Evidence=; Inhibited following phosphorylation by OXSR1/OSR1 and STK39/SPAK: phosphorylation takes place downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4) in response to hyperosmotic stress and subsequent cell shrinkage. Homodimer (By similarity). Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts (via C-terminus) with CKB; the interaction may be required for SLC12A6 potassium-chloride cotransport activity (By similarity). Q924N4-1; Q9Z1W9: Stk39; NbExp=4; IntAct=EBI-620992, EBI-444764; Cell membrane Basolateral cell membrane ; Multi-pass membrane protein Event=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=KCC3a ; IsoId=Q924N4-1; Sequence=Displayed; Name=2; Synonyms=KCC3b ; IsoId=Q924N4-2; Sequence=VSP_006117, VSP_006118; [Isoform 1]: Expressed in hippocampus and corpus callosum (at protein level) (PubMed:18566107). Highly expressed throughout the brain and detected at lower levels in kidney. Highly expressed in highly myelinated white matter of the brain, but not in gray matter. Detected in the corpus callosum, in packed cell layers of the hippocampus and in Purkinje neurons within the cerebellum. Highly expressed in white matter in the spinal cord, but not in dorsal root ganglia or sciatic nerve. Colocalizes with the oligodendrocyte marker CNP. Expressed in hippocampus in CA1, and to a lesser extent CA3 pyramidal cells (PubMed:12368912). Also expressed in cortex, mostly in large neurons and in the large cerebellar Purkinje cells (PubMed:12368912). [Isoform 2]: Highly expressed in kidney, but not detected in brain. [Isoform 2]: N-terminal loop binds to the intracellular vestibule of the transporter, arresting the transporter in an inhibited state. Phosphorylated, phosphorylation regulates transporter activity. Phosphorylated at Thr-991 and Thr-1048 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), inhibiting the potassium-chloride cotransport activity. N-glycosylated. Note=Defects in Slc12a6 are a cause of locomotor abnormalities beginning at 2 weeks of age. Slc12a6 deficient mice show hypomyelination, decompaction of myelin, demyelination, axonal swelling and fiber degeneration. Locomotor abnormalities beginning at 2 weeks of age (PubMed:12368912). Hypomyelination, decompaction of myelin, demyelination, axonal swelling and fiber degeneration (PubMed:12368912). Belongs to the SLC12A transporter family. protein binding plasma membrane integral component of plasma membrane ion transport potassium ion transport cell volume homeostasis chemical synaptic transmission potassium ion transmembrane transporter activity symporter activity cation:chloride symporter activity potassium:chloride symporter activity membrane integral component of membrane basolateral plasma membrane protein kinase binding transmembrane transporter activity axon chloride ion homeostasis potassium ion homeostasis transmembrane transport cellular hypotonic response cellular hypotonic salinity response chloride transmembrane transport potassium ion import across plasma membrane apical plasma membrane uc008lou.1 uc008lou.2 uc008lou.3 uc008lou.4 
ENSMUST00000028551.4 Emc4 ENSMUST00000028551.4 ER membrane protein complex subunit 4, transcript variant 1 (from RefSeq NM_026519.4) A2AGJ7 EMC4_MOUSE ENSMUST00000028551.1 ENSMUST00000028551.2 ENSMUST00000028551.3 NM_026519 Q9CZX9 Q9D1D9 Tmem85 uc008loy.1 uc008loy.2 uc008loy.3 Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N- exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Component of the ER membrane protein complex (EMC). Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Could also be a single-pass transmembrane protein with cytosolic N-terminus and lumenal C-terminus. Belongs to the EMC4 family. molecular_function apoptotic process membrane integral component of membrane ER membrane protein complex uc008loy.1 uc008loy.2 uc008loy.3 
ENSMUST00000028552.4 Katnbl1 ENSMUST00000028552.4 katanin p80 subunit B like 1 (from RefSeq NM_024254.3) ENSMUST00000028552.1 ENSMUST00000028552.2 ENSMUST00000028552.3 KTBL1_MOUSE NM_024254 Q3U7P7 Q8C7R6 Q9CWJ3 uc008lpa.1 uc008lpa.2 uc008lpa.3 Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro. Interacts with KATNA1 and KATNAL1; these interactions are competed by KATNB1 which has a higher affinity for them. Nucleus Cytoplasm, cytoskeleton, spindle pole Note=Localizes to the spindle poles only during mitosis. Sequestered to the nucleus during interphase. spindle pole molecular_function nucleus nucleolus cytoplasm cytoskeleton positive regulation of cytoskeleton organization mitotic spindle pole uc008lpa.1 uc008lpa.2 uc008lpa.3 
ENSMUST00000028553.4 Nop10 ENSMUST00000028553.4 NOP10 ribonucleoprotein (from RefSeq NM_025403.4) ENSMUST00000028553.1 ENSMUST00000028553.2 ENSMUST00000028553.3 NM_025403 NOP10_MOUSE Nola3 Q9CQS2 uc008lor.1 uc008lor.2 uc008lor.3 uc008lor.4 Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable core formed by binding of one or two NOP10- DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate. During assembly, the complex contains NAF1 instead of GAR1/NOLA1. The complex also interacts with TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs. Specific interactions with snoRNAs or TERC are mediated by GAR1 and NHP2. Associates with NOLC1/NOPP140. H/ACA snoRNPs interact with the SMN complex, consisting of SMN1 or SMN2, GEMIN2/SIP1, DDX20/GEMIN3, and GEMIN4. This is mediated by interaction between GAR1 and SMN1 or SMN2. The SMN complex may be required for correct assembly of the H/ACA snoRNP complex. Component of the telomerase holoenzyme complex composed of one molecule of TERT, one molecule of WRAP53/TCAB1, two molecules of H/ACA ribonucleoprotein complex subunits DKC1, NOP10, NHP2 and GAR1, and a telomerase RNA template component (TERC). The telomerase holoenzyme complex is associated with TEP1, SMG6/EST1A and POT1. Nucleus, nucleolus Nucleus, Cajal body Note=Also localized to Cajal bodies (coiled bodies). Belongs to the NOP10 family. snoRNA guided rRNA pseudouridine synthesis pseudouridine synthesis RNA binding protein binding nucleus telomerase holoenzyme complex nucleolus rRNA processing telomere maintenance via telomerase Cajal body nuclear body snoRNA binding rRNA pseudouridine synthesis snRNA pseudouridine synthesis box H/ACA snoRNP complex box H/ACA snoRNA binding ribosome biogenesis telomerase RNA binding box H/ACA telomerase RNP complex uc008lor.1 uc008lor.2 uc008lor.3 uc008lor.4 
ENSMUST00000028554.4 Lpcat4 ENSMUST00000028554.4 lysophosphatidylcholine acyltransferase 4 (from RefSeq NM_207206.2) Agpat7 Aytl3 ENSMUST00000028554.1 ENSMUST00000028554.2 ENSMUST00000028554.3 LPCT4_MOUSE NM_207206 Q66JP7 Q6NVG1 uc008loo.1 uc008loo.2 uc008loo.3 Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, 1-alkenyl- lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors (By similarity). Converts lysophosphatidylcholine to phosphatidycholine (PubMed:18156367). Reaction=a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:32995, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64381, ChEBI:CHEBI:64612; EC=2.3.1.n7; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl- CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:16245, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:77288, ChEBI:CHEBI:77290; EC=2.3.1.121; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2- diacyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:12937, ChEBI:CHEBI:57287, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:58342; EC=2.3.1.23; Evidence=; Reaction=1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O- alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:18461, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.67; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2- diacyl-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:33191, ChEBI:CHEBI:57262, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64379; EC=2.3.1.n6; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1- acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37775, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:64381, ChEBI:CHEBI:75263; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37776; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37767, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:64381, ChEBI:CHEBI:75265; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37768; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37771, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:64381, ChEBI:CHEBI:75264; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37772; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3- phosphoethanolamine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3- phosphoethanolamine + CoA; Xref=Rhea:RHEA:37731, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:64381, ChEBI:CHEBI:75238; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37732; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3- phosphoethanolamine = 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37575, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:64381, ChEBI:CHEBI:75067; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37576; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl- CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37763, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:77288, ChEBI:CHEBI:77301; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37764; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3- phosphoethanolamine + CoA; Xref=Rhea:RHEA:37755, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:77288, ChEBI:CHEBI:77303; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37756; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3- phosphoethanolamine + CoA; Xref=Rhea:RHEA:37759, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:77288, ChEBI:CHEBI:77302; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37760; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3- phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn- glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37631, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:77288, ChEBI:CHEBI:77291; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37632; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn- glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37635, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:77288, ChEBI:CHEBI:77295; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37636; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1- acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37803, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:58168, ChEBI:CHEBI:75279; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37804; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:33359, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:58168, ChEBI:CHEBI:58293; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33360; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3- phosphocholine = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:37783, ChEBI:CHEBI:34112, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37784; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn- glycero-3-phosphocholine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37787, ChEBI:CHEBI:55430, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37788; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L- serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L- serine + CoA; Xref=Rhea:RHEA:37531, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75020, ChEBI:CHEBI:75029; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37532; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho- (1'-sn-glycerol) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37647, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72827, ChEBI:CHEBI:72845; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37648; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn- glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37779, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:72827, ChEBI:CHEBI:75266; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37780; Evidence=; Lipid metabolism; phospholipid metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Widely expressed with much higher level in brain. Expressed in erythroleukemic cells but not in reticulocytes. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phospholipid metabolic process phospholipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups 1-alkenylglycerophosphoethanolamine O-acyltransferase activity 1-acylglycerophosphocholine O-acyltransferase activity 1-alkylglycerophosphocholine O-acetyltransferase activity lysophospholipid acyltransferase activity uc008loo.1 uc008loo.2 uc008loo.3 
ENSMUST00000028580.12 Ccdc34 ENSMUST00000028580.12 coiled-coil domain containing 34, transcript variant 4 (from RefSeq NR_149736.1) CCD34_MOUSE ENSMUST00000028580.1 ENSMUST00000028580.10 ENSMUST00000028580.11 ENSMUST00000028580.2 ENSMUST00000028580.3 ENSMUST00000028580.4 ENSMUST00000028580.5 ENSMUST00000028580.6 ENSMUST00000028580.7 ENSMUST00000028580.8 ENSMUST00000028580.9 NR_149736 Q3UI66 Q9CS29 Q9CS41 uc008lmr.1 uc008lmr.2 uc008lmr.3 uc008lmr.4 Involved in spermatogenesis. Has a probable role in anterograde intraflagellar transport which is essential for the formation of sperm flagella. Cell projection, cilium, flagellum Note=Mainly located in the mid-piece of sperm flagella. Expressed in testis and sperm. molecular_function cellular_component biological_process uc008lmr.1 uc008lmr.2 uc008lmr.3 uc008lmr.4 
ENSMUST00000028583.8 Lin7c ENSMUST00000028583.8 lin-7 homolog C, crumbs cell polarity complex component (from RefSeq NM_011699.4) ENSMUST00000028583.1 ENSMUST00000028583.2 ENSMUST00000028583.3 ENSMUST00000028583.4 ENSMUST00000028583.5 ENSMUST00000028583.6 ENSMUST00000028583.7 LIN7C_MOUSE Mals3 NM_011699 O88952 Veli3 uc008lmp.1 uc008lmp.2 uc008lmp.3 uc008lmp.4 Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Forms a complex with CASK and CASKIN1 (By similarity). Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2- LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (PubMed:10846156). Can also interact with other modular proteins containing protein-protein interaction domains like PALS1, PALS2, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C) (By similarity). Interacts with MAPK12. O88952; Q08460: Kcnma1; NbExp=4; IntAct=EBI-821316, EBI-1633915; Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Postsynaptic density membrane; Peripheral membrane protein. Cell junction, tight junction. Note=Mainly basolateral in renal epithelial cells. Expressed in the kidney; particularly in the outer medullary collecting duct. The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane. The PDZ domain regulates endocytosis and recycling of the receptor at the membrane. The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes. Belongs to the lin-7 family. morphogenesis of an epithelial sheet protein binding cytoplasm plasma membrane cell-cell junction bicellular tight junction exocytosis neurotransmitter secretion cytoskeletal protein binding postsynaptic density protein transport membrane basolateral plasma membrane protein domain specific binding cell junction PDZ domain binding neuron projection maintenance of epithelial cell apical/basal polarity synapse postsynaptic membrane L27 domain binding MPP7-DLG1-LIN7 complex presynapse glutamatergic synapse protein localization to basolateral plasma membrane uc008lmp.1 uc008lmp.2 uc008lmp.3 uc008lmp.4 
ENSMUST00000028584.8 Commd9 ENSMUST00000028584.8 COMM domain containing 9 (from RefSeq NM_029635.3) COMD9_MOUSE ENSMUST00000028584.1 ENSMUST00000028584.2 ENSMUST00000028584.3 ENSMUST00000028584.4 ENSMUST00000028584.5 ENSMUST00000028584.6 ENSMUST00000028584.7 NM_029635 Q3U3J2 Q7TNP5 Q811K2 Q8K2Q0 Q9D8V8 uc008lhq.1 uc008lhq.2 uc008lhq.3 May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits. Interacts with RELB and NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1. Nucleus Cytoplasmic vesicle Sequence=AAH30374.1; Type=Erroneous initiation; Evidence=; molecular_function nucleus Golgi apparatus cytosol ion transport sodium ion transport cytoplasmic vesicle cholesterol homeostasis uc008lhq.1 uc008lhq.2 uc008lhq.3 
ENSMUST00000028592.12 Eif3m ENSMUST00000028592.12 eukaryotic translation initiation factor 3, subunit M (from RefSeq NM_145380.2) EIF3M_MOUSE ENSMUST00000028592.1 ENSMUST00000028592.10 ENSMUST00000028592.11 ENSMUST00000028592.2 ENSMUST00000028592.3 ENSMUST00000028592.4 ENSMUST00000028592.5 ENSMUST00000028592.6 ENSMUST00000028592.7 ENSMUST00000028592.8 ENSMUST00000028592.9 NM_145380 Pcid1 Q3TI04 Q5EBI5 Q99JX4 uc008lkl.1 uc008lkl.2 uc008lkl.3 uc008lkl.4 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Cytoplasm Belongs to the eIF-3 subunit M family. formation of cytoplasmic translation initiation complex cytoplasmic translational initiation translation initiation factor activity cytoplasm eukaryotic translation initiation factor 3 complex translation translational initiation eukaryotic 43S preinitiation complex translation initiation factor binding eukaryotic 48S preinitiation complex eukaryotic translation initiation factor 3 complex, eIF3m uc008lkl.1 uc008lkl.2 uc008lkl.3 uc008lkl.4 
ENSMUST00000028593.11 Prrg4 ENSMUST00000028593.11 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) (from RefSeq NM_178695.5) ENSMUST00000028593.1 ENSMUST00000028593.10 ENSMUST00000028593.2 ENSMUST00000028593.3 ENSMUST00000028593.4 ENSMUST00000028593.5 ENSMUST00000028593.6 ENSMUST00000028593.7 ENSMUST00000028593.8 ENSMUST00000028593.9 NM_178695 Prgp4 Q8BGN6 Q8BM25 TMG4_MOUSE Tmg4 uc008lki.1 uc008lki.2 uc008lki.3 uc008lki.4 May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and down-regulates its expression (By similarity). Interacts (via cytoplasmic domain) with WW domain-containing proteins MAGI1, MAGI3, NEDD4, NEDD4L, WWTR1/TAZ and YAP1. Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein Cell membrane ; Single-pass type I membrane protein Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. Belongs to the commissureless family. molecular_function calcium ion binding extracellular region biological_process membrane integral component of membrane endoplasmic reticulum-Golgi intermediate compartment membrane uc008lki.1 uc008lki.2 uc008lki.3 uc008lki.4 
ENSMUST00000028595.8 Depdc7 ENSMUST00000028595.8 DEP domain containing 7 (from RefSeq NM_144804.2) DEPD7_MOUSE ENSMUST00000028595.1 ENSMUST00000028595.2 ENSMUST00000028595.3 ENSMUST00000028595.4 ENSMUST00000028595.5 ENSMUST00000028595.6 ENSMUST00000028595.7 NM_144804 Q3TN66 Q3UNR5 Q91WS7 uc008lke.1 uc008lke.2 uc008lke.3 uc008lke.4 Strongly expressed in liver and to a lower extent in kidney. Belongs to the DEPDC7 family. molecular_function cellular_component intracellular signal transduction uc008lke.1 uc008lke.2 uc008lke.3 uc008lke.4 
ENSMUST00000028599.8 Cstf3 ENSMUST00000028599.8 cleavage stimulation factor, 3' pre-RNA, subunit 3, transcript variant 1 (from RefSeq NM_145529.3) CSTF3_MOUSE ENSMUST00000028599.1 ENSMUST00000028599.2 ENSMUST00000028599.3 ENSMUST00000028599.4 ENSMUST00000028599.5 ENSMUST00000028599.6 ENSMUST00000028599.7 NM_145529 Q99LI7 uc008ljz.1 uc008ljz.2 uc008ljz.3 uc008ljz.4 One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1 (By similarity). Nucleus mRNA binding nucleus nucleoplasm RNA processing mRNA processing RNA 3'-end processing uc008ljz.1 uc008ljz.2 uc008ljz.3 uc008ljz.4 
ENSMUST00000028600.14 Hipk3 ENSMUST00000028600.14 homeodomain interacting protein kinase 3, transcript variant 1 (from RefSeq NM_010434.2) A2AQH2 ENSMUST00000028600.1 ENSMUST00000028600.10 ENSMUST00000028600.11 ENSMUST00000028600.12 ENSMUST00000028600.13 ENSMUST00000028600.2 ENSMUST00000028600.3 ENSMUST00000028600.4 ENSMUST00000028600.5 ENSMUST00000028600.6 ENSMUST00000028600.7 ENSMUST00000028600.8 ENSMUST00000028600.9 Fist3 HIPK3_MOUSE NM_010434 O88906 Q9ERH7 Q9QZR2 uc008lju.1 uc008lju.2 uc008lju.3 uc008lju.4 uc008lju.5 Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2- mediated activation of the osteocalcin FGF-responsive element (OCFRE). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts with UBL1/SUMO-1 (By similarity). Interacts with and stabilizes ligand-bound androgen receptor (AR). Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Binds to NR5A1/SF1, SPEN/MINT and RUNX2. Q9ERH7; P25446: Fas; NbExp=3; IntAct=EBI-524356, EBI-296206; Cytoplasm. Nucleus. Heart, skeletal muscle, spleen, testis and lung. Autophosphorylated, but autophosphorylation is not required for catalytic activity. May be sumoylated. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. negative regulation of transcription from RNA polymerase II promoter nucleotide binding transcription corepressor activity protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity protein binding ATP binding nucleus cytoplasm cytosol protein phosphorylation apoptotic process mRNA transcription kinase activity phosphorylation nuclear body PML body transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation negative regulation of apoptotic process positive regulation of DNA binding negative regulation of JUN kinase activity DNA binding uc008lju.1 uc008lju.2 uc008lju.3 uc008lju.4 uc008lju.5 
ENSMUST00000028607.13 Caprin1 ENSMUST00000028607.13 cell cycle associated protein 1, transcript variant 1 (from RefSeq NM_016739.4) CAPR1_MOUSE ENSMUST00000028607.1 ENSMUST00000028607.10 ENSMUST00000028607.11 ENSMUST00000028607.12 ENSMUST00000028607.2 ENSMUST00000028607.3 ENSMUST00000028607.4 ENSMUST00000028607.5 ENSMUST00000028607.6 ENSMUST00000028607.7 ENSMUST00000028607.8 ENSMUST00000028607.9 G5E5 Gpiap Gpiap1 Gpip137 M11s1 NM_016739 Q60758 Q60865 Q61620 Q6IMN3 Q7TT26 Rng105 uc008ljd.1 uc008ljd.2 uc008ljd.3 uc008ljd.4 mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:20516077). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (By similarity). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (By similarity). Binds directly and selectively to MYC and CCND2 mRNAs (By similarity). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity). Ability to mediate liquid-liquid phase separation is regulated by ATP: moderate concentrations of ATP enhance phase separation, whereas high concentrations of ATP lead to inhibition of phase separation. May form homomultimers (PubMed:14764709). Interacts with G3BP1; interaction is direct and promotes stress granule formation (PubMed:17210633). Interacts with G3BP2; interaction is direct and promotes stress granule formation (By similarity). Interacts with PQBP1 (By similarity). Interacts with DDX3X (By similarity). Interacts (when phosphorylated by EPHA4) with FMR1; interaction with FMR1 promotes formation of a membraneless compartment (By similarity). Cytoplasm, Cytoplasmic ribonucleoprotein granule Cytoplasm, cytosol Cell projection, dendrite Cell projection, lamellipodium Note=Mediates formation and localizes to cytoplasmic ribonucleoprotein membraneless compartments (By similarity) (PubMed:17210633). Associated with RNA granules (PubMed:17210633). At the leading edge of migrating fibroblasts, colocalizes with DDX3X (By similarity). Highest expression in thymus, spleen and brain (at protein level). Lower levels in kidney, muscle and liver (at protein level). Up-regulated when resting T- or B-lymphocytes or hemopoietic progenitors are activated. Down-regulated when a monocytic leukemia cell line, M1, is induced to differentiate. Expressed in brain at 17.5 dpc (at protein level). The C-terminal disordered region undergoes liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors. CAPRIN1 molecules in the condensed phase are neutral. mRNA-binding promotes phase separation. Moderate concentrations of ATP enhance phase separation by reducing the electrostatic potential of CAPRIN1, thereby promoting intermolecular interactions. In contrast, high concentrations of ATP invert the electrostatic potential of CAPRIN1, so that CAPRIN1 molecules become negatively charged, lead to inhibition of phase separation. Tyrosine phosphorylation by EPHA4 promotes interaction with FMR1 and liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. O-glycosylation by OGT inhibit ability to undergo liquid-liquid phase separation (LLPS). Belongs to the caprin family. Sequence=AAA68561.1; Type=Frameshift; Evidence=; Sequence=AAA82599.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAA61750.1; Type=Erroneous gene model prediction; Evidence=; P-body RNA binding cytoplasm cytosol cytoplasmic stress granule negative regulation of translation cell differentiation dendrite cell projection synapse positive regulation of dendrite morphogenesis positive regulation of dendritic spine morphogenesis postsynapse glutamatergic synapse uc008ljd.1 uc008ljd.2 uc008ljd.3 uc008ljd.4 
ENSMUST00000028608.13 Nat10 ENSMUST00000028608.13 N-acetyltransferase 10 (from RefSeq NM_153126.4) ENSMUST00000028608.1 ENSMUST00000028608.10 ENSMUST00000028608.11 ENSMUST00000028608.12 ENSMUST00000028608.2 ENSMUST00000028608.3 ENSMUST00000028608.4 ENSMUST00000028608.5 ENSMUST00000028608.6 ENSMUST00000028608.7 ENSMUST00000028608.8 ENSMUST00000028608.9 Kiaa1709 NAT10_MOUSE NM_153126 Nat10 Q3UE04 Q6ZPJ7 Q80VD3 Q8BW78 Q8K224 uc008liy.1 uc008liy.2 uc008liy.3 RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs. Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation. mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency. Mediates the formation of ac4C at position 1842 in 18S rRNA (By similarity). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (By similarity). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro. The relevance of the protein lysine acetyltransferase activity is however unsure in vivo. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Reaction=a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate; Xref=Rhea:RHEA:51424, Rhea:RHEA-COMP:13575, Rhea:RHEA-COMP:13576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456216; Evidence=; Reaction=a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)- acetylcytidine in tRNA + CoA + H(+) + phosphate; Xref=Rhea:RHEA:53876, Rhea:RHEA-COMP:13670, Rhea:RHEA-COMP:13671, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456216; Evidence=; Reaction=a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)- acetylcytidine in mRNA + CoA + H(+) + phosphate; Xref=Rhea:RHEA:58480, Rhea:RHEA-COMP:15145, Rhea:RHEA-COMP:15146, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456216; Evidence=; Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with THUMPD1. Interacts with SUN1 (via N-terminus). Interacts with TERT. Nucleus, nucleolus Embryonic lethality before 14.5 dpc (PubMed:29703891). Heterozygous mice are healthy and show enhanced healthspan in a Hutchinson-Gilford progeria syndrome (HGPS) mouse model; molecular mechanisms explaining the relation between Nat10 activity and nuclear architecture defects in HGPS mouse models are however unclear (PubMed:29703891). Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily. rRNA modification nucleotide binding ATP binding nucleus telomerase holoenzyme complex nucleolus rRNA processing tRNA processing N-acetyltransferase activity rRNA metabolic process transferase activity transferase activity, transferring acyl groups midbody negative regulation of telomere maintenance via telomerase ncRNA processing ribosomal small subunit biogenesis positive regulation of translation tRNA acetylation DNA polymerase binding rRNA acetylation involved in maturation of SSU-rRNA rRNA cytidine N-acetyltransferase activity uc008liy.1 uc008liy.2 uc008liy.3 
ENSMUST00000028610.10 Cat ENSMUST00000028610.10 catalase (from RefSeq NM_009804.2) CATA_MOUSE Cas-1 Cas1 ENSMUST00000028610.1 ENSMUST00000028610.2 ENSMUST00000028610.3 ENSMUST00000028610.4 ENSMUST00000028610.5 ENSMUST00000028610.6 ENSMUST00000028610.7 ENSMUST00000028610.8 ENSMUST00000028610.9 NM_009804 P24270 Q3TXQ6 uc008liw.1 uc008liw.2 uc008liw.3 uc008liw.4 Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence=; Homotetramer. Interacts (via microbody targeting signal) with PEX5, monomeric form interacts with PEX5, leading to its translocation into peroxisomes. Peroxisome Belongs to the catalase family. response to reactive oxygen species ureteric bud development response to hypoxia kidney development aminoacylase activity catalase activity peroxidase activity receptor binding extracellular space mitochondrion mitochondrial intermembrane space lysosome peroxisome peroxisomal membrane endoplasmic reticulum Golgi apparatus cytosol plasma membrane triglyceride metabolic process response to oxidative stress aging cholesterol metabolic process aerobic respiration response to radiation response to UV response to toxic substance response to light intensity UV protection response to ozone response to lead ion positive regulation of phosphatidylinositol 3-kinase signaling response to activity response to inactivity antioxidant activity oxidoreductase activity oxidoreductase activity, acting on peroxide as acceptor enzyme binding hemoglobin metabolic process heme binding negative regulation of NF-kappaB transcription factor activity response to estradiol response to insulin response to vitamin A response to vitamin E response to L-ascorbic acid response to drug response to hydrogen peroxide hydrogen peroxide catabolic process identical protein binding protein homodimerization activity negative regulation of apoptotic process intracellular membrane-bounded organelle response to ethanol response to cadmium ion metal ion binding NADP binding positive regulation of NF-kappaB transcription factor activity protein tetramerization protein homotetramerization positive regulation of cell division response to hyperoxia oxidation-reduction process response to fatty acid cellular response to growth factor stimulus response to phenylpropanoid cellular oxidant detoxification uc008liw.1 uc008liw.2 uc008liw.3 uc008liw.4 
ENSMUST00000028612.8 Pamr1 ENSMUST00000028612.8 peptidase domain containing associated with muscle regeneration 1 (from RefSeq NM_173749.4) A2AQI2 ENSMUST00000028612.1 ENSMUST00000028612.2 ENSMUST00000028612.3 ENSMUST00000028612.4 ENSMUST00000028612.5 ENSMUST00000028612.6 ENSMUST00000028612.7 NM_173749 PAMR1_MOUSE Q8BU25 Q8K2B8 Ramp uc012caf.1 uc012caf.2 uc012caf.3 uc012caf.4 May play a role in regeneration of skeletal muscle. Secreted. Predominantly expressed in normal skeletal muscle and brain. Expression is enhanced in the regenerating area of injured skeletal muscle in mice. Down-regulated in dystrophin-mutant mdx muscle cell line. Belongs to the peptidase S1 family. Although related to peptidase S1 family, lacks the conserved active Ser residue in position 665 which is replaced by a Thr, suggesting that it has no protease activity. calcium ion binding extracellular region extracellular space uc012caf.1 uc012caf.2 uc012caf.3 uc012caf.4 
ENSMUST00000028617.7 Api5 ENSMUST00000028617.7 apoptosis inhibitor 5, transcript variant 2 (from RefSeq NM_007466.4) API5_MOUSE ENSMUST00000028617.1 ENSMUST00000028617.2 ENSMUST00000028617.3 ENSMUST00000028617.4 ENSMUST00000028617.5 ENSMUST00000028617.6 NM_007466 O35841 Q3U517 Q922L2 uc008lgx.1 uc008lgx.2 uc008lgx.3 uc008lgx.4 Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity). Monomer. Interacts with FGF2 and ACIN1 (By similarity). Nucleus Cytoplasm Note=Mainly nuclear. Down-regulated in vascular smooth muscle cells (vSMCs) treated with benzo[a]pyrene (BaP). Acetylation at Lys-251 impairs antiapoptotic function. Belongs to the API5 family. nucleus spliceosomal complex cytoplasm apoptotic process nuclear speck fibroblast growth factor binding negative regulation of apoptotic process negative regulation of fibroblast apoptotic process uc008lgx.1 uc008lgx.2 uc008lgx.3 uc008lgx.4 
ENSMUST00000028619.5 Hsd17b12 ENSMUST00000028619.5 hydroxysteroid (17-beta) dehydrogenase 12 (from RefSeq NM_019657.4) ENSMUST00000028619.1 ENSMUST00000028619.2 ENSMUST00000028619.3 ENSMUST00000028619.4 Hsd17b12 NM_019657 Q0VGQ1 Q0VGQ1_MOUSE uc008lgp.1 uc008lgp.2 uc008lgp.3 Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. Reaction=(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+); Xref=Rhea:RHEA:39323, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:73852, ChEBI:CHEBI:76415; Evidence=; Reaction=(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+); Xref=Rhea:RHEA:39459, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:73863, ChEBI:CHEBI:76460; Evidence=; Reaction=(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)- hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+); Xref=Rhea:RHEA:39311, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:71481, ChEBI:CHEBI:76411; Evidence=; Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence=; Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH; Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62; Evidence=; Reaction=3-oxooctadecanoyl-CoA + H(+) + NADPH = (3R)- hydroxyoctadecanoyl-CoA + NADP(+); Xref=Rhea:RHEA:39151, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:71407, ChEBI:CHEBI:76374; Evidence=; Reaction=a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very- long-chain 3-oxoacyl-CoA + H(+) + NADPH; Xref=Rhea:RHEA:48680, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:85440, ChEBI:CHEBI:90725; EC=1.1.1.330; Evidence=; Lipid metabolism; fatty acid biosynthesis. Steroid biosynthesis; estrogen biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. membrane integral component of membrane oxidoreductase activity oxidation-reduction process uc008lgp.1 uc008lgp.2 uc008lgp.3 
ENSMUST00000028623.13 Ext2 ENSMUST00000028623.13 exostosin glycosyltransferase 2, transcript variant 2 (from RefSeq NM_010163.4) ENSMUST00000028623.1 ENSMUST00000028623.10 ENSMUST00000028623.11 ENSMUST00000028623.12 ENSMUST00000028623.2 ENSMUST00000028623.3 ENSMUST00000028623.4 ENSMUST00000028623.5 ENSMUST00000028623.6 ENSMUST00000028623.7 ENSMUST00000028623.8 ENSMUST00000028623.9 EXT2_MOUSE Ext2 NM_010163 P70395 P70428 Q3TPI7 Q923D6 uc008lgf.1 uc008lgf.2 uc008lgf.3 Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D- GlcNAc residues from their respective UDP-sugar donors (PubMed:10639137). Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl- proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling (By similarity). Reaction=3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)- beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L- seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D- GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl- [protein] + H(+) + UDP; Xref=Rhea:RHEA:16213, Rhea:RHEA-COMP:12621, Rhea:RHEA-COMP:12623, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:132415, ChEBI:CHEBI:132416; EC=2.4.1.224; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16214; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Part of the heparan sulfate polymerase, a dimeric complex composed of EXT1 and EXT2 (PubMed:10639137). Could also form homooligomeric complexes (PubMed:10639137). Interacts with NDST1 (By similarity). Interacts with GALNT5 (By similarity). P70428; Q3UHN9: Ndst1; NbExp=2; IntAct=EBI-15693102, EBI-15693148; Golgi apparatus membrane ; Single-pass type II membrane protein Golgi apparatus, cis-Golgi network membrane ; Single-pass type II membrane protein Endoplasmic reticulum membrane ; Single-pass type II membrane protein Secreted Note=The active heparan sulfate polymerase complex composed of EXT1 and EXT2 is localized to the Golgi apparatus. If both proteins are individually detected in the endoplasmic reticulum, the formation of the complex promotes their transport to the Golgi. Expressed in heart, brain, spleen, lung, liver, skeletal muscle and testis. Heart shows a high expression. Expressed in early stages of embryonic development. N-glycosylated at Asn-637. A soluble form is generated by proteolytic processing. Belongs to the glycosyltransferase 47 family. Golgi membrane ossification mesoderm formation protein binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus glycosaminoglycan biosynthetic process protein glycosylation acetylglucosaminyltransferase activity heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups cell differentiation cellular polysaccharide biosynthetic process heparan sulfate N-acetylglucosaminyltransferase activity protein homodimerization activity UDP-N-acetylglucosamine transferase complex metal ion binding protein heterodimerization activity glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity uc008lgf.1 uc008lgf.2 uc008lgf.3 
ENSMUST00000028624.9 Gatm ENSMUST00000028624.9 glycine amidinotransferase (L-arginine:glycine amidinotransferase) (from RefSeq NM_025961.5) A2AK36 ENSMUST00000028624.1 ENSMUST00000028624.2 ENSMUST00000028624.3 ENSMUST00000028624.4 ENSMUST00000028624.5 ENSMUST00000028624.6 ENSMUST00000028624.7 ENSMUST00000028624.8 GATM_MOUSE NM_025961 Q3U8U4 Q3UAM0 Q3UKD9 Q6IU01 Q9D964 uc008maw.1 uc008maw.2 uc008maw.3 uc008maw.4 Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives (By similarity). Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (By similarity). Reaction=glycine + L-arginine = guanidinoacetate + L-ornithine; Xref=Rhea:RHEA:13201, ChEBI:CHEBI:32682, ChEBI:CHEBI:46911, ChEBI:CHEBI:57305, ChEBI:CHEBI:57742; EC=2.1.4.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13202; Evidence=; Reaction=4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L- ornithine; Xref=Rhea:RHEA:75939, ChEBI:CHEBI:32682, ChEBI:CHEBI:46911, ChEBI:CHEBI:57486, ChEBI:CHEBI:59888; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75940; Evidence=; Reaction=beta-alanine + L-arginine = 3-guanidinopropanoate + L- ornithine; Xref=Rhea:RHEA:75943, ChEBI:CHEBI:32682, ChEBI:CHEBI:46911, ChEBI:CHEBI:57593, ChEBI:CHEBI:57966; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75944; Evidence=; Reaction=L-arginine + taurine = L-ornithine + taurocyamine; Xref=Rhea:RHEA:75947, ChEBI:CHEBI:32682, ChEBI:CHEBI:46911, ChEBI:CHEBI:58064, ChEBI:CHEBI:507393; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75948; Evidence=; Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2. Homodimer. Mitochondrion inner membrane Expressed in kidney, brain, gonads, uterus, and embryonic head, chest and abdomen. Maternally expressed in the placenta and yolk sac of embryos. Expressed in a wide range of extraembryonic and embryonic tissues throughout development. Expressed at relatively low levels in mid-gestation stage embryos, with expression gradually increasing during embryonic development. Knockout mice do not manifest aminoaciduria or glucosuria. Belongs to the amidinotransferase family. mitochondrion mitochondrial inner membrane mitochondrial intermembrane space creatine metabolic process creatine biosynthetic process multicellular organism development response to nutrient learning or memory response to organic substance muscle atrophy amidinotransferase activity glycine amidinotransferase activity membrane transferase activity response to peptide hormone response to mercury ion uc008maw.1 uc008maw.2 uc008maw.3 uc008maw.4 
ENSMUST00000028630.9 Slc12a1 ENSMUST00000028630.9 solute carrier family 12, member 1, transcript variant 2 (from RefSeq NM_183354.3) A2AQ50 A2AQ50_MOUSE ENSMUST00000028630.1 ENSMUST00000028630.2 ENSMUST00000028630.3 ENSMUST00000028630.4 ENSMUST00000028630.5 ENSMUST00000028630.6 ENSMUST00000028630.7 ENSMUST00000028630.8 NM_183354 Slc12a1 uc008mcg.1 uc008mcg.2 uc008mcg.3 Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) + K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the SLC12A transporter family. ion transport cation:chloride symporter activity membrane integral component of membrane transmembrane transporter activity transmembrane transport extracellular exosome chloride transmembrane transport uc008mcg.1 uc008mcg.2 uc008mcg.3 
ENSMUST00000028635.6 Cops2 ENSMUST00000028635.6 COP9 signalosome subunit 2, transcript variant 2 (from RefSeq NM_009939.3) CSN2_MOUSE Csn2 ENSMUST00000028635.1 ENSMUST00000028635.2 ENSMUST00000028635.3 ENSMUST00000028635.4 ENSMUST00000028635.5 NM_009939 O88950 P61202 Q15647 Q3V1W6 Q8R5B0 Q9CWU1 Q9R249 Q9UNQ5 Trip15 uc008mdb.1 uc008mdb.2 uc008mdb.3 uc008mdb.4 Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS1, COPS4, COPS5, COPS6 and COPS7 (COPS7A or COPS7B) (PubMed:9707402). Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Interacts with CUL1 and CUL2 (PubMed:11967155). Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1 (By similarity). Interacts with NIF3L1 (PubMed:12522100). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P61202-1; Sequence=Displayed; Name=2; IsoId=P61202-2; Sequence=VSP_011885; Widely expressed in embryonic, fetal and adult tissues, except cartilage and smooth muscle. Phosphorylated by CK2 and PKD kinases. Its absence causes arrest of embryo development at the peri-implantation stage. Blastocysts without Cops2 fail to outgrow in culture and exhibit a cell proliferation defect in inner cell mass, accompanied by a slight decrease in Oct4. In addition, lack of Cops2 disrupts the CSN complex and results in a drastic increase in cyclin E. It also induces elevated levels of p53 and p21, which may contribute to premature cell cycle arrest of the mutant. Belongs to the CSN2 family. Sequence=AAH23096.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter protein deneddylation inner cell mass cell proliferation transcription corepressor activity protein binding nucleus cytoplasm protein phosphorylation COP9 signalosome cell proliferation neuron differentiation skeletal muscle cell differentiation negative regulation of transcription, DNA-templated negative regulation of nucleic acid-templated transcription uc008mdb.1 uc008mdb.2 uc008mdb.3 uc008mdb.4 
ENSMUST00000028648.3 Syt13 ENSMUST00000028648.3 synaptotagmin XIII (from RefSeq NM_030725.5) ENSMUST00000028648.1 ENSMUST00000028648.2 Kiaa1427 NM_030725 Q6ZPR2 Q8BRK6 Q9EQT6 SYT13_MOUSE uc008lfn.1 uc008lfn.2 uc008lfn.3 May be involved in transport vesicle docking to the plasma membrane. Interacts with NRXN1. Cytoplasmic vesicle membrane ; Single-pass membrane protein Expressed in brain, heart, spleen, lung and testis. Expressed in embryo at 7 dpc onwards. The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding. The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present. Belongs to the synaptotagmin family. Sequence=BAC98167.1; Type=Erroneous initiation; Evidence=; SNARE binding phosphatidylserine binding calcium ion binding calcium-dependent phospholipid binding plasma membrane integral component of plasma membrane regulation of dopamine secretion membrane integral component of membrane vesicle-mediated transport calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis transport vesicle clathrin binding axon cytoplasmic vesicle membrane cytoplasmic vesicle neuron projection intracellular membrane-bounded organelle exocytic vesicle cellular response to calcium ion uc008lfn.1 uc008lfn.2 uc008lfn.3 
ENSMUST00000028650.9 Pex16 ENSMUST00000028650.9 peroxisomal biogenesis factor 16, transcript variant 5 (from RefSeq NR_185193.1) ENSMUST00000028650.1 ENSMUST00000028650.2 ENSMUST00000028650.3 ENSMUST00000028650.4 ENSMUST00000028650.5 ENSMUST00000028650.6 ENSMUST00000028650.7 ENSMUST00000028650.8 NR_185193 PEX16_MOUSE Q3UPY2 Q91XC9 uc008kxt.1 uc008kxt.2 uc008kxt.3 uc008kxt.4 Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity). Interacts with PEX19. Peroxisome membrane ; Multi-pass membrane protein Belongs to the peroxin-16 family. peroxisome peroxisomal membrane integral component of peroxisomal membrane endoplasmic reticulum endoplasmic reticulum membrane protein targeting to peroxisome peroxisome organization protein C-terminus binding membrane integral component of membrane peroxisome membrane biogenesis protein import into peroxisome matrix protein to membrane docking ER-dependent peroxisome organization protein import into peroxisome membrane uc008kxt.1 uc008kxt.2 uc008kxt.3 uc008kxt.4 
ENSMUST00000028656.2 Duoxa2 ENSMUST00000028656.2 dual oxidase maturation factor 2 (from RefSeq NM_025777.3) A2AQ98 DOXA2_MOUSE ENSMUST00000028656.1 NM_025777 Q9D311 Q9D7U8 uc008mam.1 uc008mam.2 Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis (By similarity). Heterodimer with DUXA2; disulfide-linked (By similarity). Interacts with CSNK1G2 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein N-glycosylated. Belongs to the DUOXA family. Sequence=BAB25910.1; Type=Frameshift; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane protein localization positive regulation of hydrogen peroxide biosynthetic process protein transport membrane integral component of membrane enzyme binding cell leading edge cellular protein localization hydrogen peroxide metabolic process apical part of cell regulation of inflammatory response protein maturation positive regulation of cell motility regulation of thyroid hormone generation uc008mam.1 uc008mam.2 
ENSMUST00000028661.6 Terb2 ENSMUST00000028661.6 telomere repeat binding bouquet formation protein 2 (from RefSeq NM_028914.1) ENSMUST00000028661.1 ENSMUST00000028661.2 ENSMUST00000028661.3 ENSMUST00000028661.4 ENSMUST00000028661.5 NM_028914 Q9D494 TERB2_MOUSE Terb2 uc008mai.1 uc008mai.2 uc008mai.3 uc008mai.4 Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. Component of the MAJIN-TERB1-TERB2 complex, composed of MAJIN, TERB1 and TERB2. Chromosome, telomere Nucleus inner membrane Note=Localizes to telomeres throughout meiotic prophase I and disappears in metaphase I. In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane. Specifically expressed in germline tissues. Mice develop normally, exhibit no overt phenotype, but are infertile (both males and females). Gonads are characterized by the absence of post-meiotic cells. Belongs to the TERB2 family. chromosome, telomeric region nuclear chromosome, telomeric region molecular_function nucleus nuclear inner membrane chromosome synapsis membrane meiotic telomere clustering meiotic cell cycle meiotic attachment of telomere to nuclear envelope uc008mai.1 uc008mai.2 uc008mai.3 uc008mai.4 
ENSMUST00000028663.5 Creb3l1 ENSMUST00000028663.5 cAMP responsive element binding protein 3-like 1 (from RefSeq NM_011957.2) A0A0R4J082 A0A0R4J082_MOUSE Creb3l1 ENSMUST00000028663.1 ENSMUST00000028663.2 ENSMUST00000028663.3 ENSMUST00000028663.4 NM_011957 uc008kxf.1 uc008kxf.2 uc008kxf.3 Endoplasmic reticulum membrane ; Single-pass type II membrane protein Nucleus negative regulation of transcription from RNA polymerase II promoter nuclear chromatin transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus endoplasmic reticulum regulation of transcription, DNA-templated negative regulation of gene expression membrane endoplasmic reticulum unfolded protein response positive regulation of collagen biosynthetic process cAMP response element binding negative regulation of fibroblast growth factor receptor signaling pathway transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter SMAD binding negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of sprouting angiogenesis positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress uc008kxf.1 uc008kxf.2 uc008kxf.3 
ENSMUST00000028665.5 Patl2 ENSMUST00000028665.5 protein associated with topoisomerase II homolog 2 (yeast) (from RefSeq NM_026251.2) A2ARM1 A6H5U9 ENSMUST00000028665.1 ENSMUST00000028665.2 ENSMUST00000028665.3 ENSMUST00000028665.4 NM_026251 PATL2_MOUSE Q9D5L4 uc008mae.1 uc008mae.2 RNA-binding protein that acts as a translational repressor. Interacts with LSM1. Cytoplasm Nucleus Belongs to the PAT1 family. Sequence=BAB29742.1; Type=Frameshift; Evidence=; deadenylation-dependent decapping of nuclear-transcribed mRNA P-body G-quadruplex RNA binding RNA binding nucleus cytoplasm poly(U) RNA binding negative regulation of cytoplasmic mRNA processing body assembly negative regulation of translation translation repressor activity cytoplasmic mRNA processing body assembly poly(G) binding ribonucleoprotein complex uc008mae.1 uc008mae.2 
ENSMUST00000028667.10 Dgkz ENSMUST00000028667.10 diacylglycerol kinase zeta, transcript variant 2 (from RefSeq NM_138306.2) A2AHJ6 DGKZ_MOUSE Dgkz ENSMUST00000028667.1 ENSMUST00000028667.2 ENSMUST00000028667.3 ENSMUST00000028667.4 ENSMUST00000028667.5 ENSMUST00000028667.6 ENSMUST00000028667.7 ENSMUST00000028667.8 ENSMUST00000028667.9 NM_138306 Q80UP3 uc008kxc.1 uc008kxc.2 uc008kxc.3 uc008kxc.4 Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12883552). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:12883552). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (By similarity). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (PubMed:12883552). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (By similarity). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (PubMed:27739494). Regulates RASGRP1 activity (By similarity). Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10273; Evidence=; Reaction=1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:16937, ChEBI:CHEBI:15378, ChEBI:CHEBI:15850, ChEBI:CHEBI:30616, ChEBI:CHEBI:58014, ChEBI:CHEBI:456216; EC=2.7.1.93; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16938; Evidence=; Reaction=1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn- glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:44072, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52595, ChEBI:CHEBI:73332, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44073; Evidence=; Reaction=1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43428, ChEBI:CHEBI:15378, ChEBI:CHEBI:18155, ChEBI:CHEBI:30616, ChEBI:CHEBI:78227, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43429; Evidence=; Reaction=1,2-ditetradecanoyl-sn-glycerol + ATP = 1,2-ditetradecanoyl- sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43444, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:80651, ChEBI:CHEBI:83550, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43445; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1- hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43416, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:64839, ChEBI:CHEBI:75466, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43417; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40335, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:72864, ChEBI:CHEBI:77096, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40336; Evidence=; Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1- octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43424, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:74560, ChEBI:CHEBI:75468, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43425; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40324; Evidence=; Reaction=1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycerol + ATP = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z- docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40359, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77129, ChEBI:CHEBI:77130, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40360; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328; Evidence=; Reaction=1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP = 1-(9Z)- octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43420, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:74551, ChEBI:CHEBI:75447, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43421; Evidence=; Reaction=1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:40331, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77093, ChEBI:CHEBI:77094, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40332; Evidence=; Reaction=1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40351, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77125, ChEBI:CHEBI:77126, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40352; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2- acetyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:41676, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75936, ChEBI:CHEBI:78385, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41677; Evidence=; Reaction=1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:40403, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77184, ChEBI:CHEBI:77186, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40404; Evidence=; Reaction=1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-O- hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40407, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77185, ChEBI:CHEBI:77187, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40408; Evidence=; Reaction=1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:41672, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:34115, ChEBI:CHEBI:77580, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41673; Evidence=; Lipid metabolism; glycerolipid metabolism. Interacts (via PDZ-binding motif) with the PDZ domain of the syntrophin SNTG1 and that of SNX27 (By similarity). Interacts with IRS1 in the absence of insulin; insulin stimulation decreases this interaction (PubMed:27739494). Found in a ternary complex with IRS1 and PIP5K1A in the absence of insulin (PubMed:27739494). Interacts with PIP5K1A (By similarity). Forms a signaling complex with RASGRP1 and HRAS (By similarity). Q80UP3; P13405: Rb1; NbExp=2; IntAct=EBI-971774, EBI-971782; Nucleus Cytoplasm, cytosol Cell membrane Cell projection, lamellipodium The PDZ-binding motif mediates interaction with PDZ domain- containing proteins like SNTG1 and SNX27. Homozygous knockout mice are viable, fertile and do not display overt phenotype (PubMed:12883552). Slight perturbations of the cellular composition of secondary lymphoid organs with a slight decrease of mature T cells is observed (PubMed:12883552). Upon TCR activation the normal conversion of diacylglycerol into phosphatidic acid that negatively regulates TCR signaling is partially impaired (PubMed:12883552). Hyper proliferation of T-cells and the ability to mount a more vigorous and effective T-cell response against pathogens indicate a more profound T-cell activation in these mice (PubMed:12883552). Belongs to the eukaryotic diacylglycerol kinase family. nucleotide binding lipid kinase activity NAD+ kinase activity diacylglycerol kinase activity enzyme inhibitor activity protein binding ATP binding nucleus cytoplasm plasma membrane phosphatidic acid biosynthetic process signal transduction protein kinase C-activating G-protein coupled receptor signaling pathway protein C-terminus binding postsynaptic density membrane kinase activity phosphorylation nuclear speck transferase activity lamellipodium mitotic G1 DNA damage checkpoint intracellular signal transduction negative regulation of catalytic activity negative regulation of mitotic cell cycle diacylglycerol metabolic process glycerolipid metabolic process negative regulation of Ras protein signal transduction lipid phosphorylation metal ion binding regulation of synaptic transmission, glutamatergic positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity glutamatergic synapse maintenance of postsynaptic density structure uc008kxc.1 uc008kxc.2 uc008kxc.3 uc008kxc.4 
ENSMUST00000028668.8 Eif3j1 ENSMUST00000028668.8 eukaryotic translation initiation factor 3, subunit J1 (from RefSeq NM_144545.4) EI3JA_MOUSE ENSMUST00000028668.1 ENSMUST00000028668.2 ENSMUST00000028668.3 ENSMUST00000028668.4 ENSMUST00000028668.5 ENSMUST00000028668.6 ENSMUST00000028668.7 Eif3s1-1 NM_144545 Q3UGC7 uc056zox.1 uc056zox.2 uc056zox.3 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Cytoplasm Phosphorylated. Phosphorylation is enhanced upon serum stimulation. Belongs to the eIF-3 subunit J family. formation of cytoplasmic translation initiation complex cytoplasmic translational initiation translation initiation factor activity cytoplasm cytosol eukaryotic translation initiation factor 3 complex translation translational initiation eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex uc056zox.1 uc056zox.2 uc056zox.3 
ENSMUST00000028672.13 Mdk ENSMUST00000028672.13 midkine, transcript variant 1 (from RefSeq NM_010784.6) ENSMUST00000028672.1 ENSMUST00000028672.10 ENSMUST00000028672.11 ENSMUST00000028672.12 ENSMUST00000028672.2 ENSMUST00000028672.3 ENSMUST00000028672.4 ENSMUST00000028672.5 ENSMUST00000028672.6 ENSMUST00000028672.7 ENSMUST00000028672.8 ENSMUST00000028672.9 MK_MOUSE Mdk Mk NM_010784 P12025 uc008kwz.1 uc008kwz.2 uc008kwz.3 uc008kwz.4 This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of several target cells including leucocytes involved in inflammation. This protein plays a role in the formation of scar tissue and intraperitoneal adhesions, and promotes neurite outgrowth and neuron survival. The protein encoded by this gene is associated with obesity and inhibition of insulin signaling in fat cells. A pseudogene of this gene is present on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. Secreted protein that functions as a cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:16901907). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:17230638). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:17230638, PubMed:19060126, PubMed:17015789, PubMed:28183532, PubMed:10683378, PubMed:15482347, PubMed:15509530, PubMed:24458438, PubMed:25551381, PubMed:29233575). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:15509530, PubMed:24458438, PubMed:28183532). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:15509530, PubMed:10683378). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:28183532). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (PubMed:17015789, PubMed:19060126). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (PubMed:15482347, PubMed:25551381). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (PubMed:17230638). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (By similarity). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (By similarity). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:10978312). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (PubMed:16901907). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (By similarity). Binds LRP1; promotes neuronal survival (By similarity). Binds ITGA4:ITGB1 complex; this interaction mediates MDK- induced osteoblast cells migration through PXN phosphorylation (By similarity). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (By similarity). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (By similarity). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (PubMed:29233575). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (PubMed:21185956, PubMed:20200993). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (PubMed:16619002, PubMed:17121547, PubMed:10096022). Homodimer. Interacts with ALK. Interacts with LRP1; promotes neuronal survival. Interacts with LRP2. Interacts with NCAM1 (By similarity). Interacts (via C-terminal) with PTPRZ1 (via chondroitin sulfate chains); this interaction is inhibited by PTN; this interaction promotes neuronal migration (PubMed:10212223). Interacts with NCL; this interaction promotes NCL clustering and lateral movements of this complex into lipid rafts leading to MDK internalization. Interacts with LRP6 and LRP8: this interaction is calcium dependent. Interacts with ITGA4. Interacts with ITGA6. Interacts with ITGB1. Interacts with ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation. Interacts with ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth. Interacts with NOTCH2; this interactio mediates a nuclear accumulation of NOTCH2 and therefore activation of NOTCH2 signaling leading to interaction between HES1 and STAT3. Interacts with GPC2 (via heparan sulfate chain); this interaction is inhibited by heparin followed by chondroitin sulfate E; this interaction induces GPC2 clustering through heparan sulfate chain; this interaction induces neuronal cell adhesion and neurite outgrowth (By similarity). Interacts with SDC3; this interaction induces SDC3 clustering; this interaction induces neuronal cell adhesion and neurite outgrowth (PubMed:9089390, PubMed:12084985). Interacts with SDC1 (PubMed:9089390). Interacts with CSPG5; this interaction promotes elongation of oligodendroglial precursor-like cells (PubMed:16901907). Secreted Expressed in the follicular epithelium and granulosa cells of the ovary. Is expressed temporarily during the early stages of retinoic acid-induced differentiation of embryonal carcinoma cells and during the mid-gestation period of mouse embryogenesis. In late embryos and in adults expression is restricted to the kidney. By retinoic acid (PubMed:2345177). Induced after tissue damage (PubMed:17015789, PubMed:19060126). Induced by inflammatory cells, in particular, CD4(+) T cells under inflammatory conditions (PubMed:22323540). Induced during the early and intermediate phase of fracture repair (PubMed:25551381). Homozygous knockout MDK mice are viable and reproduce normally. Mice have no apparent abnormalities except that postnatal development of the hippocampus is delayed. However 4 weeks after birth, mice have a deficit in their working memory and have an increased anxiety (PubMed:10096022). Knockout MDK mice exhibit low to moderate levels of auditory deficits and generally respond at around 50 dB. PTN and MDK double knockoutmice have a deficit of auditory response (PubMed:16619002). PTN and MDK double knockout mice are born in only one third the number expected by Mendelian segregation and 4 weeks after birth weigh about half as much as wild-type mice. Most of the female are infertile. Both male and female one-month-old mice show a defect in spontaneous locomotive activity of 50-60% of that of wild- type mice. Although the difference in activity decrease with age, the activity of 3-month-old male double knockout mice is still about 80% of that of the wild-type mice. The diestrus and proestrus periods are long and the estrus period is short. Furthermore, vaginal abnormality is found in about half of the double deficient mice (PubMed:17121547). Homozygous knockout MDK mice display not significant difference from wild-type until the age of 6 month. Mice at 12 and 18 months of age show an increased trabecular bone volume, accompanied by cortical porosity (PubMed:20200993). Belongs to the pleiotrophin family. behavioral fear response leukocyte chemotaxis involved in inflammatory response T cell activation involved in immune response positive regulation of leukocyte chemotaxis protein binding extracellular region cytoplasm cytoskeleton organization negative regulation of cell adhesion signal transduction multicellular organism development short-term memory growth factor activity heparin binding response to wounding response to hormone negative regulation of cardiac muscle cell apoptotic process positive regulation of epithelial to mesenchymal transition positive regulation of macrophage chemotaxis positive regulation of keratinocyte proliferation positive regulation of neuron projection development response to auditory stimulus cell migration dentate gyrus development cerebellar granular layer development hippocampus development cerebral cortex development cell differentiation negative regulation of ossification adrenal gland development positive regulation of cell migration defecation regulation of chondrocyte differentiation chondroitin sulfate binding tissue regeneration response to drug cell projection negative regulation of neuron apoptotic process estrous cycle positive regulation of T cell differentiation negative regulation of regulatory T cell differentiation positive regulation of cell adhesion positive regulation of transcription, DNA-templated regulation of bone remodeling oogenesis positive regulation of oligodendrocyte differentiation positive regulation of inflammatory response regulation of behavior response to glucocorticoid positive regulation of cell division positive regulation of cartilage development positive regulation of smooth muscle cell chemotaxis positive regulation of neutrophil chemotaxis negative regulation of canonical Wnt signaling pathway positive regulation of substrate adhesion-dependent cell spreading negative regulation of neuron death positive regulation of leukocyte cell-cell adhesion negative regulation of epithelial cell apoptotic process heparan sulfate binding positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation blood vessel branching positive regulation of vascular endothelial cell proliferation positive regulation of artery morphogenesis positive regulation of neural precursor cell proliferation regulation of actin cytoskeleton reorganization positive regulation of hepatocyte proliferation positive regulation of neutrophil extravasation positive regulation of interleukin-12 secretion positive regulation of neuron migration uc008kwz.1 uc008kwz.2 uc008kwz.3 uc008kwz.4 
ENSMUST00000028679.11 Ell3 ENSMUST00000028679.11 Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT). (from UniProt Q80VR2) A2ARQ1 AK139676 ELL3_MOUSE ENSMUST00000028679.1 ENSMUST00000028679.10 ENSMUST00000028679.2 ENSMUST00000028679.3 ENSMUST00000028679.4 ENSMUST00000028679.5 ENSMUST00000028679.6 ENSMUST00000028679.7 ENSMUST00000028679.8 ENSMUST00000028679.9 Q80VR2 uc008lzc.1 uc008lzc.2 uc008lzc.3 Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT). Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2 (By similarity). Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with AFF4. Nucleus Actively expressed in embryonic stem cells (ES cells), while it is weakly expressed in differentiated cells. Belongs to the ELL/occludin family. protein binding nucleus nucleoplasm nucleolus DNA-templated transcription, elongation transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter transcription elongation factor complex regulation of epithelial to mesenchymal transition positive regulation of DNA-templated transcription, elongation enhancer binding snRNA transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter stem cell differentiation positive regulation of neurogenesis negative regulation of signal transduction by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of neural precursor cell proliferation uc008lzc.1 uc008lzc.2 uc008lzc.3 
ENSMUST00000028681.15 F2 ENSMUST00000028681.15 coagulation factor II (from RefSeq NM_010168.4) ENSMUST00000028681.1 ENSMUST00000028681.10 ENSMUST00000028681.11 ENSMUST00000028681.12 ENSMUST00000028681.13 ENSMUST00000028681.14 ENSMUST00000028681.2 ENSMUST00000028681.3 ENSMUST00000028681.4 ENSMUST00000028681.5 ENSMUST00000028681.6 ENSMUST00000028681.7 ENSMUST00000028681.8 ENSMUST00000028681.9 F2 NM_010168 Q3TJ94 Q3TJ94_MOUSE uc008kwg.1 uc008kwg.2 uc008kwg.3 uc008kwg.4 This gene encodes a vitamin K-dependent glycoprotein coagulation factor that plays an important role in the process of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that undergoes enzymatic cleavage by the coagulation factor Xa to form an active serine protease that converts soluble fibrinogen to insoluble fibrin clot. Most of the mice lacking the encoded protein die at an embryonic stage due to defects in yolk sac vasculature, while the rare nenonates succumb to hemorrhage on the first postnatal day. [provided by RefSeq, Apr 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X52308.1, AK149367.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Reaction=Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.; EC=3.4.21.5; Evidence= Belongs to the peptidase S1 family. Lacks conserved residue(s) required for the propagation of feature annotation. lipopolysaccharide binding positive regulation of protein phosphorylation serine-type endopeptidase activity receptor binding calcium ion binding extracellular region extracellular space proteolysis acute-phase response cell surface receptor signaling pathway blood coagulation hemostasis heparin binding peptidase activity serine-type peptidase activity response to wounding external side of plasma membrane hydrolase activity platelet activation positive regulation of blood coagulation positive regulation of collagen biosynthetic process fibrinolysis negative regulation of proteolysis negative regulation of astrocyte differentiation positive regulation of release of sequestered calcium ion into cytosol regulation of cytosolic calcium ion concentration cytolysis by host of symbiont cells thrombospondin receptor activity neutrophil mediated killing of gram-negative bacterium positive regulation of lipid kinase activity negative regulation of cytokine production involved in inflammatory response positive regulation of protein localization to nucleus positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of reactive oxygen species metabolic process uc008kwg.1 uc008kwg.2 uc008kwg.3 uc008kwg.4 
ENSMUST00000028683.14 Pdia3 ENSMUST00000028683.14 protein disulfide isomerase associated 3 (from RefSeq NM_007952.2) ENSMUST00000028683.1 ENSMUST00000028683.10 ENSMUST00000028683.11 ENSMUST00000028683.12 ENSMUST00000028683.13 ENSMUST00000028683.2 ENSMUST00000028683.3 ENSMUST00000028683.4 ENSMUST00000028683.5 ENSMUST00000028683.6 ENSMUST00000028683.7 ENSMUST00000028683.8 ENSMUST00000028683.9 Erp Erp60 Grp58 NM_007952 P27773 PDIA3_MOUSE Q3TEI9 Q3TIL2 Q3UZK8 Q8C2F4 Q99LF6 uc008lzb.1 uc008lzb.2 uc008lzb.3 uc008lzb.4 Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity. Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; Evidence=; Part of the major histocompatibility complex class I (MHC I) peptide loading complex composed of TAP1, TAP2, B2M, MHC heavy chain, TAPBP, PDIA3, and CALR. Interacts with ERP27 and CANX. Interacts with SERPINA2 and with SERPINA1 (By similarity). Interacts with ATP2A2 (PubMed:23395171). Endoplasmic reticulum Endoplasmic reticulum lumen Melanosome In caput and cauda epididymal spermatozoa, detected in the acrosome and principal piece (at protein level). Phosphorylated. Within the major histocompatibility complex class I (MHC I) peptide loading complex forms reversible disulfide-linked heterodimers with TAPBP as part of its protein folding chaperone activity. This is essential to assist the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Belongs to the protein disulfide isomerase family. Was originally thought to be a phosphatidylinositol 4,5- bisphosphate phosphodiesterase type I (phospholipase C-alpha). acrosomal vesicle protein disulfide isomerase activity protein binding extracellular region extracellular space nucleus cytoplasm mitochondrion mitochondrial intermembrane space endoplasmic reticulum endoplasmic reticulum lumen smooth endoplasmic reticulum plasma membrane protein folding proteolysis peptidase activity cell surface peptide disulfide oxidoreductase activity apical plasma membrane isomerase activity protein-disulfide reductase (glutathione) activity response to endoplasmic reticulum stress MHC class I protein binding melanosome identical protein binding MHC class I peptide loading complex TAP complex myelin sheath cell redox homeostasis oxidation-reduction process cellular response to vitamin D cellular response to interleukin-7 positive regulation of protein folding positive regulation of extrinsic apoptotic signaling pathway uc008lzb.1 uc008lzb.2 uc008lzb.3 uc008lzb.4 
ENSMUST00000028689.4 Lrp4 ENSMUST00000028689.4 low density lipoprotein receptor-related protein 4, transcript variant 1 (from RefSeq NM_172668.3) A2AGT4 ENSMUST00000028689.1 ENSMUST00000028689.2 ENSMUST00000028689.3 Kiaa0816 LRP4_MOUSE NM_172668 Q8BPX5 Q8CBB3 Q8CCP5 Q8VI56 uc008kvx.1 uc008kvx.2 uc008kvx.3 uc008kvx.4 Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. Plays an essential role in the process of digit differentiation (PubMed:16517118). Homooligomer. Interacts with MUSK; the heterodimer forms an AGRIN receptor complex that binds AGRIN resulting in activation of MUSK. Interacts (via the extracellular domain) with SOST; the interaction facilitates the inhibition of Wnt signaling (By similarity). Interacts with MESD; the interaction promotes glycosylation of LRP4 and its cell-surface expression (PubMed:24140340). Q8VI56; Q9ERE7: Mesd; NbExp=2; IntAct=EBI-2106160, EBI-6662606; Q8VI56; P25304: Agrn; Xeno; NbExp=3; IntAct=EBI-2106160, EBI-2106099; Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VI56-1; Sequence=Displayed; Name=2; IsoId=Q8VI56-2; Sequence=VSP_010034; N-glycosylation is required for cell surface location. Note=Defects in Lrp4 are the cause of digitation anormale (dan) phenotype, this mutation is the consequence of a retroviral insertion. Dan mice shown growth retardation in 10-day-old mice dan/dan and polysyndactyly (PubMed:16517118). Defects in Lrp4 are the cause of malformed digits (mdig) phenotype. It is a spontaneous, autosomal recessive mutation resulting in polysyndactyly (PubMed:16517118). Belongs to the LDLR family. Sequence=BAC27835.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAC29416.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; kidney development regulation of protein phosphorylation hair follicle development calcium ion binding protein binding plasma membrane endocytosis multicellular organism development protein localization dorsal/ventral pattern formation proximal/distal pattern formation cell surface postsynaptic density membrane integral component of membrane Wnt signaling pathway cell differentiation negative regulation of ossification embryonic limb morphogenesis dendrite receptor tyrosine kinase binding neuromuscular junction apolipoprotein binding odontogenesis of dentin-containing tooth embryonic digit morphogenesis protein homodimerization activity neuronal cell body receptor clustering plasma membrane raft dendrite morphogenesis anatomical structure development positive regulation of peptidyl-tyrosine phosphorylation negative regulation of axonogenesis synapse organization synaptic growth at neuromuscular junction protein heterotetramerization limb development skeletal muscle acetylcholine-gated channel clustering negative regulation of canonical Wnt signaling pathway synaptic membrane postsynaptic membrane assembly presynaptic membrane assembly scaffold protein binding positive regulation of presynaptic membrane organization positive regulation of skeletal muscle acetylcholine-gated channel clustering uc008kvx.1 uc008kvx.2 uc008kvx.3 uc008kvx.4 
ENSMUST00000028696.5 Ddb2 ENSMUST00000028696.5 damage specific DNA binding protein 2, transcript variant 1 (from RefSeq NM_028119.5) DDB2_MOUSE ENSMUST00000028696.1 ENSMUST00000028696.2 ENSMUST00000028696.3 ENSMUST00000028696.4 NM_028119 Q99J79 uc008kvh.1 uc008kvh.2 uc008kvh.3 uc008kvh.4 uc008kvh.5 Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:12107171). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:33937266). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (By similarity). Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4- DDB-ROC1 and CUL4-DDB-RBX1) (By similarity). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV- induced DNA damage (By similarity). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (By similarity). The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (By similarity). The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR (By similarity). Protein modification; protein ubiquitination. Component of the UV-DDB complex which includes DDB1 and DDB2. The UV-DDB complex interacts with monoubiquitinated histone H2A and binds to XPC via the DDB2 subunit. Component of the DCX (DDB1-CUL4-X- box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1), which includes CUL4A or CUL4B, DDB1, DDB2 and RBX1. DDB2 may function as the substrate recognition module within this complex. The DDB1-CUL4-ROC1 complex may associate with the COP9 signalosome, and this inhibits the E3 ubiquitin-protein ligase activity of the complex. A large number of other DCX complexes may also exist in which an alternate substrate targeting subunit replaces DDB2. These targeting subunits are generally known as DCAF (DDB1- and CUL4- associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins (By similarity). Nucleus Chromosome Note=Accumulates at sites of DNA damage following UV irradiation. Expressed in bone marrow, liver, lung, muscle, pancreas and spleen. The DWD box is required for interaction with DDB1. Interblade loops of the WD repeat region mediate most of the interaction with DNA. A hairpin between blades 5 and 6 inserts into DNA minor groove and mediates recognition of lesions and separation of the damaged and undamaged strands (By similarity). Phosphorylation by ABL1 negatively regulate UV-DDB activity. Ubiquitinated by CUL4A in response to UV irradiation. Ubiquitination appears to both impair DNA-binding and promotes ubiquitin-dependent proteolysis. Degradation of DDB2 at sites of DNA damage may be a prerequisite for their recognition by XPC and subsequent repair. CUL4A-mediated degradation appears to be promoted by ABL1. Ubiquitinated, leading to proteasomal degradation, and deubiquitinated by USP24 (By similarity). Deubiquitinated by USP44; leading to its stabilization on DNA lesions (PubMed:33937266). Acetylated. Deacetylation by SIRT6 in response to UV stress facilitates nucleotide excision repair pathway (the NER pathway) transduction. Mice exhibit elevated susceptibility to UV- induced skin carcinogenesis and enhanced rates of spontaneous tumor formation, particularly for lung and mammary adenocarcinomas. DDB2 is haploinsufficient as a tumor suppressor. The spleens of these animals are enlarged due to enhanced lymphoid proliferation while the testes are also enlarged due to reduced rates of apoptosis of testicular germ cells. Fibroblasts from these animals are resistant to p53-dependent apoptosis induced by UV treatment. Belongs to the WD repeat DDB2/WDR76 family. protein polyubiquitination DNA binding damaged DNA binding ubiquitin-protein transferase activity nucleus nucleoplasm DNA repair pyrimidine dimer repair cellular response to DNA damage stimulus response to UV protein ubiquitination cell junction Cul4B-RING E3 ubiquitin ligase complex macromolecular complex histone H2A monoubiquitination macromolecular complex binding protein autoubiquitination UV-damage excision repair Cul4-RING E3 ubiquitin ligase complex uc008kvh.1 uc008kvh.2 uc008kvh.3 uc008kvh.4 uc008kvh.5 
ENSMUST00000028704.3 Hao1 ENSMUST00000028704.3 hydroxyacid oxidase 1, liver (from RefSeq NM_010403.2) ENSMUST00000028704.1 ENSMUST00000028704.2 HAOX1_MOUSE Hao1 NM_010403 Q9WU19 uc008mns.1 uc008mns.2 uc008mns.3 Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate (PubMed:9891009). The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine- glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones (By similarity). Can also catalyze the oxidation glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate (By similarity). Active in vitro with the artificial electron acceptor 2,6- dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2 (PubMed:9891009). Reaction=a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2; Xref=Rhea:RHEA:16789, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:35179, ChEBI:CHEBI:58123; EC=1.1.3.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16790; Evidence=; Reaction=glycolate + O2 = glyoxylate + H2O2; Xref=Rhea:RHEA:25311, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:29805, ChEBI:CHEBI:36655; EC=1.1.3.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25312; Evidence=; Reaction=glyoxylate + H2O + O2 = H(+) + H2O2 + oxalate; Xref=Rhea:RHEA:14837, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:30623, ChEBI:CHEBI:36655; EC=1.2.3.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14838; Evidence=; Reaction=2-hydroxyhexadecanoate + O2 = 2-oxohexadecanoate + H2O2; Xref=Rhea:RHEA:67944, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:65097, ChEBI:CHEBI:176593; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67945; Evidence=; Reaction=2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2; Xref=Rhea:RHEA:67940, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:133514, ChEBI:CHEBI:176689; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67941; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Amino-acid biosynthesis; glycine biosynthesis. Homotetramer. Peroxisome matrix Liver. Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. fatty acid alpha-oxidation catalytic activity (S)-2-hydroxy-acid oxidase activity L-lactate dehydrogenase activity peroxisome response to oxidative stress glycolate oxidase activity FMN binding oxidoreductase activity lactate oxidation glycolate catabolic process very-long-chain-(S)-2-hydroxy-acid oxidase activity long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity medium-chain-(S)-2-hydroxy-acid oxidase activity oxidation-reduction process uc008mns.1 uc008mns.2 uc008mns.3 
ENSMUST00000028721.8 Tgm5 ENSMUST00000028721.8 transglutaminase 5, transcript variant 1 (from RefSeq NM_028799.4) A2AQ62 ENSMUST00000028721.1 ENSMUST00000028721.2 ENSMUST00000028721.3 ENSMUST00000028721.4 ENSMUST00000028721.5 ENSMUST00000028721.6 ENSMUST00000028721.7 NM_028799 Q3V1F9 Q9D7I9 TGM5_MOUSE uc008lxl.1 uc008lxl.2 uc008lxl.3 Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes (By similarity). Reaction=L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L- lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:54816, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:14005, ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:30011, ChEBI:CHEBI:138370; EC=2.3.2.13; Evidence= Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Cytoplasm Note=Associated with intermediate filaments. Belongs to the transglutaminase superfamily. Transglutaminase family. protein-glutamine gamma-glutamyltransferase activity cellular_component cytoplasm transferase activity transferase activity, transferring acyl groups peptide cross-linking metal ion binding uc008lxl.1 uc008lxl.2 uc008lxl.3 
ENSMUST00000028728.6 Ubr1 ENSMUST00000028728.6 ubiquitin protein ligase E3 component n-recognin 1 (from RefSeq NM_009461.3) A2AQ54 ENSMUST00000028728.1 ENSMUST00000028728.2 ENSMUST00000028728.3 ENSMUST00000028728.4 ENSMUST00000028728.5 NM_009461 O70481 Q5BKR8 Q792M3 Q8BN40 Q8C5K3 UBR1_MOUSE uc008lxb.1 uc008lxb.2 uc008lxb.3 uc008lxb.4 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with RECQL4. Cytoplasm, cytosol Present in skeletal muscle and liver (at protein level). Broadly expressed, with highest levels in skeletal muscle and heart. Expressed in acinar cells of the pancreas. In testes, expressed primarily in spermatogonia. Expressed in limb buds at 9.5-11.5 dpc. In models of cancer cachexia, induced in muscle during the progression of wasting. The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif. The UBR-type zinc finger forms a pocket that mediates recognition of type 1 N-degrons. It exhibits preference for Arginine in first position, has poor affinity for histidine, and doesn't bind acetylated peptides (By similarity). Mice are viable and fertile, but show a decreased mass of skeletal muscle and adipose tissue. They have exocrine pancreatic insufficiency with impaired stimulus-secretion coupling and increased susceptibiliy to pancreatic injury. UBR1 and UBR2 double knockout embryos die at midgestation, with defects in neurogenesis and cardiovascular development. These defects included reduced proliferation as well as precocious migration and differentiation of neural progenitor cells. Belongs to the UBR1 family. Sequence=AAH90969.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; ubiquitin ligase complex proteasome complex ubiquitin-protein transferase activity protein binding cytoplasm cytosol ubiquitin-dependent protein catabolic process zinc ion binding protein ubiquitination transferase activity protein catabolic process negative regulation of TOR signaling metal ion binding ubiquitin protein ligase activity leucine binding cellular response to leucine ubiquitin-dependent protein catabolic process via the N-end rule pathway uc008lxb.1 uc008lxb.2 uc008lxb.3 uc008lxb.4 
ENSMUST00000028735.8 Jag1 ENSMUST00000028735.8 jagged 1 (from RefSeq NM_013822.5) ENSMUST00000028735.1 ENSMUST00000028735.2 ENSMUST00000028735.3 ENSMUST00000028735.4 ENSMUST00000028735.5 ENSMUST00000028735.6 ENSMUST00000028735.7 JAG1_MOUSE NM_013822 Q9QXX0 uc008moz.1 uc008moz.2 uc008moz.3 uc008moz.4 Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis. Interacts with NOTCH1, NOTCH2 and NOTCH3. Membrane; Single-pass type I membrane protein. Cell membrane Widely expressed in many tissues, with highest expression in brain, heart, muscle and thymus. At 8.75-9.75 dpc expression was detected in structures that include those destined to contribute to the cardiovascular system of the adult heart. Expression was also detected in the mesencephalon and rhombencephalon. The DSL domain is indispensable and sufficient for binding to NOTCH2. negative regulation of cell-matrix adhesion blood vessel remodeling morphogenesis of an epithelial sheet T cell mediated immunity pulmonary valve morphogenesis cardiac right ventricle morphogenesis Notch binding calcium ion binding protein binding phospholipid binding plasma membrane adherens junction cell communication Notch signaling pathway multicellular organism development animal organ morphogenesis positive regulation of gene expression membrane integral component of membrane apical plasma membrane negative regulation of cell-cell adhesion negative regulation of cell migration response to muramyl dipeptide aorta morphogenesis regulation of cell proliferation auditory receptor cell differentiation camera-type eye development apical part of cell negative regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of endothelial cell differentiation positive regulation of myeloid cell differentiation negative regulation of neuron differentiation positive regulation of osteoblast differentiation negative regulation of Notch signaling pathway positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter receptor agonist activity inner ear development cardiac septum morphogenesis ciliary body morphogenesis pulmonary artery morphogenesis cardiac neural crest cell development involved in outflow tract morphogenesis Notch signaling involved in heart development endocardial cushion cell development nephron development glomerular visceral epithelial cell development distal tubule development loop of Henle development neuronal stem cell population maintenance negative regulation of stem cell differentiation uc008moz.1 uc008moz.2 uc008moz.3 uc008moz.4 
ENSMUST00000028749.15 Capn3 ENSMUST00000028749.15 calpain 3, transcript variant a (from RefSeq NM_007601.3) A2AVV3 CAN3_MOUSE ENSMUST00000028749.1 ENSMUST00000028749.10 ENSMUST00000028749.11 ENSMUST00000028749.12 ENSMUST00000028749.13 ENSMUST00000028749.14 ENSMUST00000028749.2 ENSMUST00000028749.3 ENSMUST00000028749.4 ENSMUST00000028749.5 ENSMUST00000028749.6 ENSMUST00000028749.7 ENSMUST00000028749.8 ENSMUST00000028749.9 NM_007601 Q64691 Q9WUC5 uc008lvz.1 uc008lvz.2 uc008lvz.3 uc008lvz.4 Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-410'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53. Reaction=Broad endopeptidase activity.; EC=3.4.22.54; Activated by micromolar concentrations of calcium and inhibited by calpastatin. Homodimer; via EF-hand domain 4. Interacts with TTN/titin. Interacts with CMYA5; this interaction, which results in CMYA5 proteolysis, may protect CAPN3 from autolysis. Interacts with SIMC1. Interacts with UTP25; the interaction is required for CAPN3 translocation to the nucleolus. Q64691; Q9ES46: Parvb; NbExp=3; IntAct=EBI-21927513, EBI-6914996; Cytoplasm Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q64691-1; Sequence=Displayed; Name=Short; IsoId=Q64691-2; Sequence=VSP_005230, VSP_005231; Belongs to the peptidase C2 family. catalytic activity calcium-dependent cysteine-type endopeptidase activity receptor binding calcium ion binding protein binding nucleus cytoplasm cytosol plasma membrane proteolysis peptidase activity structural constituent of muscle programmed cell death positive regulation of satellite cell activation involved in skeletal muscle regeneration response to muscle activity hydrolase activity enzyme binding myofibril Z disc protein catabolic process myofibril assembly T-tubule sodium ion binding titin binding protein destabilization macromolecular complex negative regulation of protein sumoylation negative regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling sarcomere organization regulation of myoblast differentiation positive regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated metal ion binding regulation of catalytic activity positive regulation of NF-kappaB transcription factor activity positive regulation of release of sequestered calcium ion into cytosol response to calcium ion ligase regulator activity binding, bridging muscle structure development macromolecular complex assembly G1 to G0 transition involved in cell differentiation cellular response to calcium ion cellular response to salt stress protein localization to membrane self proteolysis sodium-dependent self proteolysis calcium-dependent self proteolysis negative regulation of skeletal muscle cell differentiation uc008lvz.1 uc008lvz.2 uc008lvz.3 uc008lvz.4 
ENSMUST00000028752.8 Vps39 ENSMUST00000028752.8 VPS39 HOPS complex subunit, transcript variant 2 (from RefSeq NM_178851.4) ENSMUST00000028752.1 ENSMUST00000028752.2 ENSMUST00000028752.3 ENSMUST00000028752.4 ENSMUST00000028752.5 ENSMUST00000028752.6 ENSMUST00000028752.7 NM_178851 Pldn Q8R5L3 Q922I3 VPS39_MOUSE Vam6 uc008lvk.1 uc008lvk.2 uc008lvk.3 uc008lvk.4 May play a role in clustering and fusion of late endosomes and lysosomes (By similarity). Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2- dependent transcription (By similarity). Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes. Required for fusion of endosomes and autophagosomes with lysosomes (By similarity). Homooligomer (By similarity). Interacts with TGFBR2 and, less efficiently, with TGFBR1; interaction with TGFBR2 is independent of the receptor kinase activity and of the presence of TGF-beta. Also interacts with ACVR2B, but not with BMPR2. Interacts with SMAD4, preferentially following TGF-beta treatment (By similarity). Component of the putative homotypic fusion and vacuole protein sorting (HOPS) complex; the core of which composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, is associated with VPS39 and VPS41. Interacts with PLEKHM2; involved in VPS39 recruitment to ARL8B-containing lysosomes (By similarity). Associates with adaptor protein complex 3 (AP-3) and clathrin:AP-3 complexes (PubMed:21411634). Interacts with STX17; this interaction is increased in the absence of TMEM39A (By similarity). Cytoplasm Lysosome membrane ; Peripheral membrane protein Late endosome membrane ; Peripheral membrane protein Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R5L3-1; Sequence=Displayed; Name=2; IsoId=Q8R5L3-2; Sequence=VSP_004076; Embryonic lethal, before E6.5. Belongs to the VAM6/VPS39 family. protein binding cytoplasm lysosome lysosomal membrane endosome late endosome intracellular protein transport autophagy endosome to lysosome transport protein transport membrane vesicle-mediated transport HOPS complex late endosome membrane endosomal vesicle fusion late endosome to lysosome transport retrograde transport, endosome to plasma membrane AP-3 adaptor complex uc008lvk.1 uc008lvk.2 uc008lvk.3 uc008lvk.4 
ENSMUST00000028755.8 Ehd4 ENSMUST00000028755.8 EH-domain containing 4, transcript variant 4 (from RefSeq NR_184851.1) EHD4_MOUSE ENSMUST00000028755.1 ENSMUST00000028755.2 ENSMUST00000028755.3 ENSMUST00000028755.4 ENSMUST00000028755.5 ENSMUST00000028755.6 ENSMUST00000028755.7 Ehd4 NR_184851 Past2 Q9EQP2 uc008lvd.1 uc008lvd.2 uc008lvd.3 ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport. Homooligomer, and heterooligomer with EHD1, EHD2 and EHD3. Q9EQP2; Q9QY17: Pacsin2; Xeno; NbExp=4; IntAct=EBI-491022, EBI-491201; Q9EQP2; Q9Z2P6: Snap29; Xeno; NbExp=2; IntAct=EBI-491022, EBI-492883; Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Recycling endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane ; Peripheral membrane protein ; Cytoplasmic side The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily. nucleotide binding calcium ion binding protein binding ATP binding GTP binding endosome endoplasmic reticulum plasma membrane pinocytosis membrane regulation of endocytosis early endosome membrane endocytic recycling metal ion binding perinuclear region of cytoplasm positive regulation of peptidyl-tyrosine phosphorylation protein homooligomerization recycling endosome membrane cellular response to growth factor stimulus uc008lvd.1 uc008lvd.2 uc008lvd.3 
ENSMUST00000028758.8 Itpka ENSMUST00000028758.8 inositol 1,4,5-trisphosphate 3-kinase A (from RefSeq NM_146125.2) A2AQ20 ENSMUST00000028758.1 ENSMUST00000028758.2 ENSMUST00000028758.3 ENSMUST00000028758.4 ENSMUST00000028758.5 ENSMUST00000028758.6 ENSMUST00000028758.7 IP3KA_MOUSE Itpka NM_146125 Q8R071 uc008luf.1 uc008luf.2 uc008luf.3 Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5- trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. Reaction=1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+); Xref=Rhea:RHEA:11020, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57895, ChEBI:CHEBI:203600, ChEBI:CHEBI:456216; EC=2.7.1.127; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11021; Evidence=; Activated by calcium/calmodulin. Cytoplasm, cytoskeleton Belongs to the inositol phosphokinase (IPK) family. nucleotide binding calmodulin-dependent protein kinase activity calmodulin binding ATP binding inositol metabolic process protein phosphorylation inositol-1,4,5-trisphosphate 3-kinase activity kinase activity phosphorylation transferase activity actin cytoskeleton organization inositol phosphate biosynthetic process dendritic spine regulation of synaptic plasticity Rac GTPase binding positive regulation of dendritic spine morphogenesis dendritic spine maintenance uc008luf.1 uc008luf.2 uc008luf.3 
ENSMUST00000028759.13 Ltk ENSMUST00000028759.13 leukocyte tyrosine kinase, transcript variant 4 (from RefSeq NM_203345.2) A2AQ22 ENSMUST00000028759.1 ENSMUST00000028759.10 ENSMUST00000028759.11 ENSMUST00000028759.12 ENSMUST00000028759.2 ENSMUST00000028759.3 ENSMUST00000028759.4 ENSMUST00000028759.5 ENSMUST00000028759.6 ENSMUST00000028759.7 ENSMUST00000028759.8 ENSMUST00000028759.9 LTK_MOUSE Ltk NM_203345 P08923 uc008lui.1 uc008lui.2 The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons. [provided by RefSeq, Jul 2008]. Receptor with a tyrosine-protein kinase activity. Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (By similarity). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity). The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence= Activated by ligand-binding, leading to homodimerization and autophosphorylation. Homodimer; homodimerizes following ligand-binding. Part of a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2. Cell membrane ingle-pass type I membrane protein [Isoform A]: Endoplasmic reticulum Note=Retained in the endoplasmic reticulum. [Isoform B]: Endoplasmic reticulum Note=Retained in the endoplasmic reticulum. Event=Alternative promoter usage, Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=D ; IsoId=P08923-1; Sequence=Displayed; Name=A ; IsoId=P08923-2; Sequence=VSP_002950, VSP_002951, VSP_002952; Name=B ; IsoId=P08923-3; Sequence=VSP_002950, VSP_002951; Name=C ; IsoId=P08923-4; Sequence=VSP_002952; Subsets of lymphoid and neuronal cells. Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. Mice do not show any decrease in newborn neurons (PubMed:22079349). Mice lacking both Alk and Ltk show a strong reduction in newborn neurons (PubMed:22079349). [Isoform D]: May be produced by alternative promoter usage. [Isoform A]: May be produced by alternative promoter usage. Starts at a CUG codon. [Isoform B]: May be produced by alternative promoter usage. Starts at a CUG codon. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Sequence=CAA30793.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding endoplasmic reticulum plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway cell proliferation positive regulation of cardiac muscle cell apoptotic process positive regulation of neuron projection development phosphatidylinositol 3-kinase signaling membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation regulation of cell proliferation negative regulation of apoptotic process receptor complex regulation of neuron differentiation cellular response to retinoic acid uc008lui.1 uc008lui.2 
ENSMUST00000028761.5 Ubox5 ENSMUST00000028761.5 U box domain containing 5, transcript variant 2 (from RefSeq NM_080562.5) ENSMUST00000028761.1 ENSMUST00000028761.2 ENSMUST00000028761.3 ENSMUST00000028761.4 NM_080562 Q925F4 RNF37_MOUSE Rnf37 Uip5 uc008mjk.1 uc008mjk.2 uc008mjk.3 uc008mjk.4 uc008mjk.5 May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with UBE2L3. Interacts with VCP. Nucleus Note=Enriched in nuclear bodies. Expressed in testis and placenta. Expressed in embryos at 14.5 dpc. The U-box domain mediates interaction with E2 ubiquitin ligases and is required for the ubiquitin-protein ligase activity. protein polyubiquitination ubiquitin-protein transferase activity nucleus nucleoplasm focal adhesion protein ubiquitination nuclear body transferase activity ubiquitin protein ligase binding ubiquitin-ubiquitin ligase activity metal ion binding ubiquitin protein ligase activity uc008mjk.1 uc008mjk.2 uc008mjk.3 uc008mjk.4 uc008mjk.5 
ENSMUST00000028763.10 Tyro3 ENSMUST00000028763.10 TYRO3 protein tyrosine kinase 3, transcript variant 1 (from RefSeq NM_019392.3) Dtk ENSMUST00000028763.1 ENSMUST00000028763.2 ENSMUST00000028763.3 ENSMUST00000028763.4 ENSMUST00000028763.5 ENSMUST00000028763.6 ENSMUST00000028763.7 ENSMUST00000028763.8 ENSMUST00000028763.9 NM_019392 O09070 O09080 P55144 P70285 Q60752 Q62482 Q62483 Q62484 Q6NZM6 Q78E85 Q78E87 Rse TYRO3_MOUSE Tif uc008luq.1 uc008luq.2 uc008luq.3 Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TULP1 and GAS6. Interacts with PIK3R1; this interaction increases PI3-kinase activity (By similarity). Cell membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=3; Name=3; Synonyms=III; IsoId=P55144-1; Sequence=Displayed; Name=2; Synonyms=II; IsoId=P55144-2; Sequence=VSP_012549; Name=1; Synonyms=I, B; IsoId=P55144-3; Sequence=VSP_012548; Abundant in the brain and lower levels in other tissues. Autophosphorylated. knockout mice are fertile, but male animals that lack all three receptors TYRO3, AXL and MERTK produce no mature sperm. Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. Sequence=AAB26942.1; Type=Erroneous initiation; Evidence=; Sequence=CAA54995.1; Type=Erroneous initiation; Evidence=; nucleotide binding natural killer cell differentiation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding nucleus nuclear envelope endoplasmic reticulum membrane plasma membrane integral component of plasma membrane protein phosphorylation phagocytosis cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway neuropeptide signaling pathway spermatogenesis nervous system development cell surface membrane integral component of membrane kinase activity phosphorylation cell migration transferase activity peptidyl-tyrosine phosphorylation forebrain cell migration platelet activation secretion by cell negative regulation of toll-like receptor signaling pathway substrate adhesion-dependent cell spreading ovulation cycle receptor complex apoptotic cell clearance protein kinase B signaling negative regulation of neuron apoptotic process phosphatidylinositol 3-kinase binding negative regulation of innate immune response protein autophosphorylation protein heterodimerization activity negative regulation of inflammatory response negative regulation of lymphocyte activation vagina development neuron cellular homeostasis platelet aggregation uc008luq.1 uc008luq.2 uc008luq.3 
ENSMUST00000028764.6 Oxt ENSMUST00000028764.6 oxytocin (from RefSeq NM_011025.4) ENSMUST00000028764.1 ENSMUST00000028764.2 ENSMUST00000028764.3 ENSMUST00000028764.4 ENSMUST00000028764.5 NM_011025 Oxt Q545V4 Q545V4_MOUSE uc008mjg.1 uc008mjg.2 uc008mjg.3 uc008mjg.4 uc008mjg.5 This gene encodes a preproprotein that is processed to produce oxytocin and neurophysin 1. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin 1. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation, the stress response and complex sexual and maternal behavior, as well as in the regulation of water excretion, salt appetite, blood pressure and cardiovascular functions. Deletion of this gene in mouse reduces bone formation resulting in osteoporosis. [provided by RefSeq, Dec 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW455577.1, AK003042.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Neurophysin 1 specifically binds oxytocin. Belongs to the vasopressin/oxytocin family. response to amphetamine regulation of heart rate maternal aggressive behavior neuropeptide hormone activity neurohypophyseal hormone activity extracellular region extracellular space cytoplasm signal transduction positive regulation of cytosolic calcium ion concentration heart development female pregnancy memory grooming behavior response to mechanical stimulus response to sucrose positive regulation of norepinephrine secretion response to organic cyclic compound response to activity secretory granule sleep oxytocin receptor binding response to food positive regulation of prostaglandin secretion response to estradiol response to retinoic acid response to progesterone response to prostaglandin E social behavior negative regulation of urine volume positive regulation of renal sodium excretion response to cocaine hyperosmotic salinity response maternal behavior sperm ejaculation eating behavior drinking behavior terminal bouton response to external biotic stimulus response to peptide hormone regulation of digestive system process response to ether negative regulation of blood pressure positive regulation of blood pressure positive regulation of ossification positive regulation of female receptivity response to steroid hormone positive regulation of synaptic transmission response to glucocorticoid response to cAMP response to electrical stimulus regulation of sensory perception of pain positive regulation of synapse assembly male mating behavior positive regulation of penile erection positive regulation of hindgut contraction negative regulation of gastric acid secretion positive regulation of uterine smooth muscle contraction uc008mjg.1 uc008mjg.2 uc008mjg.3 uc008mjg.4 uc008mjg.5 
ENSMUST00000028767.9 Rtf1 ENSMUST00000028767.9 RTF1, Paf1/RNA polymerase II complex component (from RefSeq NM_030112.2) A2AQ19 ENSMUST00000028767.1 ENSMUST00000028767.2 ENSMUST00000028767.3 ENSMUST00000028767.4 ENSMUST00000028767.5 ENSMUST00000028767.6 ENSMUST00000028767.7 ENSMUST00000028767.8 NM_030112 Q08EC5 RTF1_MOUSE uc008lue.1 uc008lue.2 uc008lue.3 Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Binds single-stranded DNA (By similarity). Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex. Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. The PAF1 complex interacts with PHF5A (PubMed:27749823). Nucleus, nucleoplasm The Plus3 domain mediates single-stranded DNA-binding. It is uncertain whether Met-1 or Met-46 is the initiator. Sequence=AAI17849.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI17850.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter endodermal cell fate commitment blastocyst growth DNA binding single-stranded DNA binding nucleus nucleoplasm nucleolus Wnt signaling pathway Cdc73/Paf1 complex stem cell population maintenance positive regulation of transcription elongation from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter positive regulation of histone H3-K4 methylation histone H3-K4 trimethylation RNA polymerase II C-terminal domain phosphoserine binding protein binding uc008lue.1 uc008lue.2 uc008lue.3 
ENSMUST00000028768.2 Ndufaf1 ENSMUST00000028768.2 As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. (from UniProt A0A0R4J081) A0A0R4J081 A0A0R4J081_MOUSE AK050343 ENSMUST00000028768.1 Ndufaf1 uc008luc.1 uc008luc.2 As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. Mitochondrion Belongs to the CIA30 family. mitochondrion cytosol mitochondrial respiratory chain complex I assembly uc008luc.1 uc008luc.2 
ENSMUST00000028769.14 Ptpra ENSMUST00000028769.14 protein tyrosine phosphatase receptor type A, transcript variant 3 (from RefSeq NM_001355161.1) ENSMUST00000028769.1 ENSMUST00000028769.10 ENSMUST00000028769.11 ENSMUST00000028769.12 ENSMUST00000028769.13 ENSMUST00000028769.2 ENSMUST00000028769.3 ENSMUST00000028769.4 ENSMUST00000028769.5 ENSMUST00000028769.6 ENSMUST00000028769.7 ENSMUST00000028769.8 ENSMUST00000028769.9 NM_001355161 Ptpra Q91V35 Q91V35_MOUSE uc008mjd.1 uc008mjd.2 uc008mjd.3 uc008mjd.4 Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Cell membrane ; Single-pass type I membrane protein Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein dephosphorylation membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc008mjd.1 uc008mjd.2 uc008mjd.3 uc008mjd.4 
ENSMUST00000028780.4 Chac1 ENSMUST00000028780.4 ChaC, cation transport regulator 1 (from RefSeq NM_026929.4) A2AV63 Botch CHAC1_MOUSE Chac1 ENSMUST00000028780.1 ENSMUST00000028780.2 ENSMUST00000028780.3 NM_026929 Q8R3J5 Q9D944 uc008lts.1 uc008lts.2 uc008lts.3 uc008lts.4 uc008lts.5 uc008lts.6 Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (By similarity). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). Reaction=glutathione = 5-oxo-L-proline + L-cysteinylglycine; Xref=Rhea:RHEA:47724, ChEBI:CHEBI:57925, ChEBI:CHEBI:58402, ChEBI:CHEBI:61694; EC=4.3.2.7; Evidence=; Kinetic parameters: KM=3.13 mM for glutathione ; Vmax=980 umol/h/mg enzyme ; Interacts with NOTCH1 (via extracellular region). Cytoplasm, cytosol Golgi apparatus, trans-Golgi network Widely expressed, with high expression in forebrain and anterior spinal cord. Expressed at intermediate level in the dorsal aorta and heart. Present throughout adult brain (at protein level). Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily. gamma-glutamylcyclotransferase activity Notch binding cytoplasm Golgi apparatus trans-Golgi network cytosol glutathione catabolic process apoptotic process response to unfolded protein Notch signaling pathway nervous system development negative regulation of protein processing lyase activity neurogenesis negative regulation of Notch signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress uc008lts.1 uc008lts.2 uc008lts.3 uc008lts.4 uc008lts.5 uc008lts.6 
ENSMUST00000028781.9 Atrn ENSMUST00000028781.9 attractin (from RefSeq NM_009730.3) A2AP43 ATRN_MOUSE ENSMUST00000028781.1 ENSMUST00000028781.2 ENSMUST00000028781.3 ENSMUST00000028781.4 ENSMUST00000028781.5 ENSMUST00000028781.6 ENSMUST00000028781.7 ENSMUST00000028781.8 Mg Mgca NM_009730 Q9R263 Q9WU60 Q9WU77 uc008mkc.1 uc008mkc.2 uc008mkc.3 uc008mkc.4 This gene encodes a widely expressed transmembrane glycoprotein that plays important roles in diverse physiological processes such as regulation of hair pigmentation, monocyte-T cell interaction and control of energy homeostasis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Certain mutations in this gene are responsible for the mahogany mouse phenotype of dark brown or black coat on a normally agouti background. Mice with loss-of-function mutations in this gene exhibit black coat color, tremor, adiposity, higher basal metabolic rate, juvenile-onset hypomyelination and age-dependent spongiform neurodegeneration of the central nervous system. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC141054.1, AK155069.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines (By similarity). May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system (By similarity). Monomer and homotrimer. Cell membrane ; Single-pass type I membrane protein Heavily glycosylated. Sequence=AAD20947.1; Type=Frameshift; Evidence=; Name=Functional Glycomics Gateway - Glycan Binding; Note=Attractin; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_150"; protein binding extracellular space cytoplasm plasma membrane inflammatory response response to oxidative stress animal organ morphogenesis tissue development membrane integral component of membrane cerebellum development carbohydrate binding signaling receptor activity regulation of multicellular organism growth myelination pigmentation uc008mkc.1 uc008mkc.2 uc008mkc.3 uc008mkc.4 
ENSMUST00000028783.14 Spint1 ENSMUST00000028783.14 serine protease inhibitor, Kunitz type 1, transcript variant 1 (from RefSeq NM_016907.3) ENSMUST00000028783.1 ENSMUST00000028783.10 ENSMUST00000028783.11 ENSMUST00000028783.12 ENSMUST00000028783.13 ENSMUST00000028783.2 ENSMUST00000028783.3 ENSMUST00000028783.4 ENSMUST00000028783.5 ENSMUST00000028783.6 ENSMUST00000028783.7 ENSMUST00000028783.8 ENSMUST00000028783.9 Hai1 NM_016907 Q99J04 Q9R097 SPIT1_MOUSE uc008ltk.1 uc008ltk.2 uc008ltk.3 uc008ltk.4 Inhibitor of HGFAC (By similarity). Inhibits serine protease activity of ST14/matriptase in vitro (By similarity). Inhibits serine protease activity of TMPRSS13, via the BPTI/Kunitz inhibitor 1 domain (By similarity). Interacts with HGFAC (By similarity). Interacts with TMPRSS13; the interaction promotes the phosphorylation and cell membrane localization of TMPRSS13 (By similarity). Secreted Cytoplasm Cell membrane This inhibitor contains two inhibitory domains. neural tube closure embryonic placenta development serine-type endopeptidase inhibitor activity extracellular region plasma membrane negative regulation of peptidase activity negative regulation of endopeptidase activity extracellular matrix organization peptidase inhibitor activity positive regulation of glial cell differentiation viral entry into host cell branching involved in labyrinthine layer morphogenesis placenta blood vessel development cellular response to BMP stimulus negative regulation of neural precursor cell proliferation uc008ltk.1 uc008ltk.2 uc008ltk.3 uc008ltk.4 
ENSMUST00000028787.12 Gfra4 ENSMUST00000028787.12 glial cell line derived neurotrophic factor family receptor alpha 4, transcript variant 2 (from RefSeq NM_020014.2) A2AP44 A2AP46 A2AP47 A2AP49 ENSMUST00000028787.1 ENSMUST00000028787.10 ENSMUST00000028787.11 ENSMUST00000028787.2 ENSMUST00000028787.3 ENSMUST00000028787.4 ENSMUST00000028787.5 ENSMUST00000028787.6 ENSMUST00000028787.7 ENSMUST00000028787.8 ENSMUST00000028787.9 GFRA4_MOUSE NM_020014 Q9JJT2 Q9JJT3 Q9JJT4 Q9JJT6 Q9JJT7 Q9JJT8 uc008mke.1 uc008mke.2 uc008mke.3 uc008mke.4 This gene encodes a transmembrane protein that functions as the receptor for persephin, a member of the glial cell line derived neurotrophic factors. The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the receptor tyrosine kinase Ret. A complete lack of the encoded protein impairs production of thyroid calcitonin and increases the rate of bone formation in young mice. [provided by RefSeq, Jul 2016]. Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. Interacts with SORL1. [Isoform a1]: Cell membrane; Lipid-anchor, GPI- anchor. [Isoform b1]: Cell membrane; Lipid-anchor, GPI- anchor. [Isoform a3]: Secreted [Isoform b3]: Secreted Event=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist. Tissue-specific and, developmentally regulated splicing.; Name=a1; IsoId=Q9JJT2-1; Sequence=Displayed; Name=a2; IsoId=Q9JJT2-2; Sequence=VSP_007227; Name=a3; IsoId=Q9JJT2-3; Sequence=VSP_007228, VSP_007229; Name=b1; IsoId=Q9JJT2-4; Sequence=VSP_007226; Name=b2; IsoId=Q9JJT2-5; Sequence=VSP_007226, VSP_007227; Name=b3; IsoId=Q9JJT2-6; Sequence=VSP_007226, VSP_007228, VSP_007229; Expressed in many tissues including adrenal medulla, brain neurons, with highest levels in the cerebral cortex and hippocampus. Moderate levels found in the gut circular muscle and myenteric ganglia as well as in other peripheral ganglia, including the sensory dorsal root and trigeminal as well as superior cervical and sympathetic chain ganglia. Isoform a1, isoform a2, isoform b1 and isoform b2 are exclusively found in the thyroid, parthyroid and pituitary glands. Expressed in several tissues at different embryonic and postnatal stages such as the condensing mesenchyme of developing bones and developing nervous system. Expressed in the developing pituitary gland from 16 dpc and in developing thyroid C- cells from 14 dpc. In the ventral spinal cord, levels decline before birth. In the parathyroid, levels first detected in 3- to 6-week-old mice with high expression. In the adrenal medulla, expressed only in newborn, postnatal (P08) and adult mice. Isoform a1 and isoform b1 are prefentially expressed in 3-week-old thyroid, isoform a2 and isoform b2 in newborn and 6-week-old thyroid glands as well as in postnatal adrenal and pituitary glands. [Isoform b1]: Alternative N-terminal. Probably non- functional. [Isoform b2]: Alternative N-terminal. Probably non- functional. [Isoform b3]: Alternative N-terminal. Probably non- functional. Belongs to the GDNFR family. extracellular region extracellular space plasma membrane transmembrane receptor protein tyrosine kinase signaling pathway nervous system development external side of plasma membrane coreceptor activity membrane glial cell-derived neurotrophic factor receptor activity negative regulation of ossification anchored component of membrane glial cell-derived neurotrophic factor receptor signaling pathway signaling receptor activity receptor complex uc008mke.1 uc008mke.2 uc008mke.3 uc008mke.4 
ENSMUST00000028794.10 Siglec1 ENSMUST00000028794.10 sialic acid binding Ig-like lectin 1, sialoadhesin (from RefSeq NM_011426.3) ENSMUST00000028794.1 ENSMUST00000028794.2 ENSMUST00000028794.3 ENSMUST00000028794.4 ENSMUST00000028794.5 ENSMUST00000028794.6 ENSMUST00000028794.7 ENSMUST00000028794.8 ENSMUST00000028794.9 G3X8X6 G3X8X6_MOUSE NM_011426 Siglec1 uc008mko.1 uc008mko.2 membrane integral component of membrane carbohydrate binding uc008mko.1 uc008mko.2 
ENSMUST00000028795.10 Rad51 ENSMUST00000028795.10 RAD51 recombinase, transcript variant 1 (from RefSeq NM_011234.5) ENSMUST00000028795.1 ENSMUST00000028795.2 ENSMUST00000028795.3 ENSMUST00000028795.4 ENSMUST00000028795.5 ENSMUST00000028795.6 ENSMUST00000028795.7 ENSMUST00000028795.8 ENSMUST00000028795.9 NM_011234 Q08297 Q3UAY5 RAD51_MOUSE Rad51 Rad51a Reca uc008ltd.1 uc008ltd.2 uc008ltd.3 Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:15834424). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (By similarity). Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination. Interacts with BRCA1 and either directly or indirectly with p53. Interacts with XRCC3, RAD54L and RAD54B. Interacts with the BCDX2 subcomplex RAD51C:RAD51B. Component of the homologous recombination repair (HR) complex composed of ERCC5/XPG, BRCA2, PALB2, DSS1 and RAD51 (By similarity). Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1, and this may require prior phosphorylation of CHEK1 (By similarity). Interacts with the MND1-PSMC3IP heterodimer (PubMed:15834424). Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts with SPIDR; the interaction is direct and recruits RAD51 to DNA damage sites. Interacts with FIGNL1 (via N-terminal one-half region); the interaction is direct. Interacts with RAD51AP1 (via C-terminal region); the interaction is direct (By similarity). Interacts with NABP2, RPA1, PALB2 and RAD51. Interacts with SWI5/C9orf119, and at lower level with SFR1/MEIR5 (PubMed:20976249). Interacts with hyperphosphorylated RPA2; this interaction is necessary for efficient recruitment to chromatin in response to DNA damage. Interacts with SWSAP1; involved in homologous recombination repair. Interacts with PARPBP, BRCA2 and RECQL5; these interactions interfere with the formation of the RAD51-DNA homologous recombination structure. Interacts with POLQ; POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends. Interacts with POLN (By similarity). Interacts with FBH1 (PubMed:24108124). Interacts with RFWD3 (By similarity). Interacts with the MCM8-MCM9 complex; the interaction recruits RAD51 to DNA damage sites (By similarity). Component of a multiprotein complex with MEIOB and SPATA22. Interacts with the complex BRME1:HSF2BP:BRCA2 (PubMed:32345962, PubMed:30760716). Interacts with HELQ; stimulating HELQ DNA helicase activity and ability to unwing DNA (By similarity). Interacts with MMS22L; the interaction is direct and promotes recruitment of RAD51 to sites of DNA damage (By similarity). Interacts with the ATAD5 RFC-like complex (By similarity). Within the ATAD5 RFC-like complex, interacts with ATAD5 (via N-terminus); the interaction is direct and enhanced under replication stress (By similarity). Interacts with WDR48; the interaction is enhanced under replication stress (By similarity). Interacts with DNA helicase ZGRF1; the interaction promotes RAD51 strand exchange activity (By similarity). Interacts (when phosphorylated) with TOPBP1; interaction takes place following phosphorylation by CK2 and PLK1 and promotes recruitment to DNA damage sites (By similarity). Nucleus Cytoplasm Cytoplasm, perinuclear region Mitochondrion matrix Chromosome toplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels. Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a SPIDR-dependent manner. Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner. Recruited at sites of DNA damage following interaction with TOPBP1 in S-phase. Colocalizes with ERCC5/XPG to nuclear foci in S phase. Recruited to stalled replication forks during replication stress by the TONSL-MMS22L complex, as well as ATAD5 and WDR48 in an ATR- dependent manner. Expressed in the testes (at protein level) (PubMed:35547804, PubMed:8341671). Expressed in the brain (at protein level) (PubMed:22305526). Expressed in the thymus, spleen, ovary and small intestine (PubMed:8341671). Expression in the brain is strongest at day 12 dpc, particularly in the cortical ventricular zone. In the cortex of newborn mice (P0), RAD51 is mainly present in the subplate and, in lesser amounts, in layer V. It is detected in a subpopulation of corticospinal axons at the pyramidal decussation in 2-day-old (P2) mice. Ubiquitinated by the SCF(FBH1) E3 ubiquitin ligase complex, regulating RAD51 subcellular location and preventing its association with DNA. Ubiquitinated by RFWD3 in response to DNA damage: ubiquitination leads to degradation by the proteasome, promoting homologous recombination. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylated at Ser-14 by PLK1, triggering phosphorylation at Thr-13 by CK2, thereby promoting interaction with TOPBP1 and recruitment to DNA damage sites during S-phase. Phosphorylation by ABL1 inhibits function. The nucleus of a mouse embryonic stem (ES) cells contains on average 4.7 x 10(5) molecules. Belongs to the RecA family. RAD51 subfamily. recombinase activity nucleotide binding nuclear chromosome telomere maintenance via recombination double-strand break repair via homologous recombination DNA recombinase assembly nuclear chromosome, telomeric region chromatin nuclear chromatin condensed chromosome condensed nuclear chromosome synaptonemal complex lateral element regulation of protein phosphorylation DNA binding chromatin binding double-stranded DNA binding single-stranded DNA binding protein binding ATP binding nucleus nucleoplasm chromosome nucleolus cytoplasm mitochondrion mitochondrial matrix microtubule organizing center cytosol cytoskeleton DNA metabolic process DNA unwinding involved in DNA replication DNA repair DNA recombination mitotic recombination cellular response to DNA damage stimulus meiosis I reciprocal meiotic recombination protein C-terminus binding DNA-dependent ATPase activity response to toxic substance response to X-ray regulation of double-strand break repair via homologous recombination telomere maintenance via telomere lengthening response to organic cyclic compound PML body single-stranded DNA-dependent ATP-dependent DNA helicase activity enzyme binding replication fork processing telomere organization macromolecular complex site of double-strand break interstrand cross-link repair strand invasion response to drug identical protein binding perinuclear region of cytoplasm positive regulation of DNA ligation protein homooligomerization meiotic cell cycle DNA polymerase binding chromosome organization involved in meiotic cell cycle cellular response to alkaloid cellular response to ionizing radiation cellular response to gamma radiation cellular response to hydroxyurea cellular response to cisplatin cellular response to camptothecin response to glucoside replication-born double-strand break repair via sister chromatid exchange mitotic recombination-dependent replication fork processing uc008ltd.1 uc008ltd.2 uc008ltd.3 
ENSMUST00000028796.2 Rpusd2 ENSMUST00000028796.2 RNA pseudouridylate synthase domain containing 2 (from RefSeq NM_173450.3) ENSMUST00000028796.1 NM_173450 Q149F1 Q8BXL2 RUSD2_MOUSE Rpusd2 uc008lsz.1 uc008lsz.2 uc008lsz.3 uc008lsz.4 uc008lsz.5 Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. Reaction=a uridine in mRNA = a pseudouridine in mRNA; Xref=Rhea:RHEA:56644, Rhea:RHEA-COMP:14658, Rhea:RHEA-COMP:14659, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Belongs to the pseudouridine synthase RluA family. enzyme-directed rRNA pseudouridine synthesis pseudouridine synthesis RNA binding RNA modification pseudouridine synthase activity uc008lsz.1 uc008lsz.2 uc008lsz.3 uc008lsz.4 uc008lsz.5 
ENSMUST00000028801.8 Spef1 ENSMUST00000028801.8 Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (PubMed:16206169). Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia (PubMed:30535028). Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs (By similarity). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity). (from UniProt Q99JL1) A2ANS9 AK046964 Clamp ENSMUST00000028801.1 ENSMUST00000028801.2 ENSMUST00000028801.3 ENSMUST00000028801.4 ENSMUST00000028801.5 ENSMUST00000028801.6 ENSMUST00000028801.7 Q543S5 Q99JL1 Q9D4J8 SPEF1_MOUSE uc290apn.1 uc290apn.2 Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (PubMed:16206169). Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia (PubMed:30535028). Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs (By similarity). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity). Homodimer (PubMed:30535028). Interacts with actin, TJP1, CGN and CDH1 (By similarity). Cytoplasm Cell projection, cilium, flagellum Cytoplasm, cytoskeleton, cilium axoneme Apical cell membrane Basolateral cell membrane Cytoplasm, cytoskeleton, stress fiber Cell projection, microvillus Cell projection, lamellipodium Cell projection, filopodium Note=Also found at the apical tip of cilia (PubMed:30535028). Present in the tails of developing and epididymal sperm, internal to the fibrous sheath and around the outer dense fibers of the sperm flagellum (PubMed:15979255). Colocalizes with TJP1 and CGN at sites of cell-cell contact in intestinal epithelial cells (By similarity). Expressed predominantly in the seminiferous epithelium of adult testis (PubMed:15979255). Expressed in pillar cells of the organ of Corti (at protein level). Expressed in brain, kidney, lung and testis (PubMed:16206169, PubMed:30535028). Highly expressed in the trachea, lung and oviduct (PubMed:30535028). Expression is first detected in the testis at 3 weeks and continues to adulthood. The Calponin-homology domain mediates its binding to microtubules. Depletion in ependymal cells by RNAi completely abolishes the central pair microtubules and markedly attenuates ciliary localizations of HYDIN and SPAG6, resulting in rotational beat of the ependymal cilia. Radial intercalation is a developmentally reiterated form of migration by which cells move in a direction orthogonal to the plane of the tissue from an inner layer to an outer layer. cytoplasm cytoskeleton cilium axoneme negative regulation of microtubule depolymerization microtubule binding cell migration motile cilium cell projection regulation of cytoskeleton organization uc290apn.1 uc290apn.2 
ENSMUST00000028804.15 Cdc25b ENSMUST00000028804.15 cell division cycle 25B, transcript variant 1 (from RefSeq NM_023117.4) Cdc25b ENSMUST00000028804.1 ENSMUST00000028804.10 ENSMUST00000028804.11 ENSMUST00000028804.12 ENSMUST00000028804.13 ENSMUST00000028804.14 ENSMUST00000028804.2 ENSMUST00000028804.3 ENSMUST00000028804.4 ENSMUST00000028804.5 ENSMUST00000028804.6 ENSMUST00000028804.7 ENSMUST00000028804.8 ENSMUST00000028804.9 NM_023117 Q3U535 Q3U535_MOUSE uc008mky.1 uc008mky.2 uc008mky.3 uc008mky.4 uc008mky.5 Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Belongs to the MPI phosphatase family. spindle pole protein tyrosine phosphatase activity centrosome protein phosphorylation protein dephosphorylation protein kinase binding positive regulation of cytokinesis peptidyl-tyrosine dephosphorylation positive regulation of mitotic cell cycle positive regulation of cell cycle G2/M phase transition uc008mky.1 uc008mky.2 uc008mky.3 uc008mky.4 uc008mky.5 
ENSMUST00000028807.6 Ivd ENSMUST00000028807.6 isovaleryl coenzyme A dehydrogenase, transcript variant 1 (from RefSeq NM_019826.5) ENSMUST00000028807.1 ENSMUST00000028807.2 ENSMUST00000028807.3 ENSMUST00000028807.4 ENSMUST00000028807.5 IVD_MOUSE NM_019826 Q9CYI3 Q9DBD7 Q9JHI5 uc008lsv.1 uc008lsv.2 uc008lsv.3 Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl- CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA. Reaction=3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:12276, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57344, ChEBI:CHEBI:57345, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307; EC=1.3.8.4; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl- CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:43456, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57389, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:86160; Evidence=; Reaction=H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:43464, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:62077, ChEBI:CHEBI:62620; Evidence=; Reaction=butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:24004, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57332, ChEBI:CHEBI:57371, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307; EC=1.3.8.1; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy- 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. Homotetramer. Mitochondrion matrix Acetylation of Lys-76 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the acyl-CoA dehydrogenase family. acyl-CoA dehydrogenase activity mitochondrion mitochondrial matrix leucine catabolic process isovaleryl-CoA dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors mitochondrial membrane fatty acid beta-oxidation using acyl-CoA dehydrogenase flavin adenine dinucleotide binding oxidation-reduction process uc008lsv.1 uc008lsv.2 uc008lsv.3 
ENSMUST00000028814.15 Rassf2 ENSMUST00000028814.15 Ras association (RalGDS/AF-6) domain family member 2, transcript variant 1 (from RefSeq NM_175445.4) ENSMUST00000028814.1 ENSMUST00000028814.10 ENSMUST00000028814.11 ENSMUST00000028814.12 ENSMUST00000028814.13 ENSMUST00000028814.14 ENSMUST00000028814.2 ENSMUST00000028814.3 ENSMUST00000028814.4 ENSMUST00000028814.5 ENSMUST00000028814.6 ENSMUST00000028814.7 ENSMUST00000028814.8 ENSMUST00000028814.9 Kiaa0168 NM_175445 Q6A0B2 Q8BMS9 RASF2_MOUSE uc008mmf.1 uc008mmf.2 uc008mmf.3 uc008mmf.4 Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation (By similarity). Interacts directly with activated KRAS in a GTP-dependent manner. Interacts (via SARAH domain) with STK3/MST2 and STK4/MST1. Nucleus Cytoplasm Chromosome, centromere, kinetochore Note=Translocates to the cytoplasm in the presence of STK3/MST2 and STK4/MST1. Phosphorylated by STK3/MST2 and STK4/MST1. Sequence=BAD32184.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; chromosome, centromeric region kinetochore condensed chromosome kinetochore skeletal system development ossification protein kinase activity protein binding nucleus nucleoplasm chromosome cytoplasm Golgi apparatus cytosol plasma membrane protein phosphorylation cell cycle signal transduction positive regulation of protein autophosphorylation macromolecular complex negative regulation of peptidyl-serine phosphorylation epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade regulation of apoptotic process positive regulation of apoptotic process regulation of osteoblast differentiation regulation of osteoclast differentiation positive regulation of protein kinase activity positive regulation of JNK cascade bone remodeling homeostasis of number of cells protein stabilization regulation of NIK/NF-kappaB signaling negative regulation of NIK/NF-kappaB signaling uc008mmf.1 uc008mmf.2 uc008mmf.3 uc008mmf.4 
ENSMUST00000028815.15 Slc23a2 ENSMUST00000028815.15 solute carrier family 23 (nucleobase transporters), member 2, transcript variant 9 (from RefSeq NR_185307.1) ENSMUST00000028815.1 ENSMUST00000028815.10 ENSMUST00000028815.11 ENSMUST00000028815.12 ENSMUST00000028815.13 ENSMUST00000028815.14 ENSMUST00000028815.2 ENSMUST00000028815.3 ENSMUST00000028815.4 ENSMUST00000028815.5 ENSMUST00000028815.6 ENSMUST00000028815.7 ENSMUST00000028815.8 ENSMUST00000028815.9 Kiaa0238 NR_185307 Q80Y23 Q8C327 Q9EPR4 Q9JM78 S23A2_MOUSE Svct2 Yspl2 uc008mmi.1 uc008mmi.2 Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. Reaction=L-ascorbate(out) + 2 Na(+)(out) = L-ascorbate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:69883, ChEBI:CHEBI:29101, ChEBI:CHEBI:38290; Evidence=; Interacts with CLSTN3. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EPR4-1; Sequence=Displayed; Name=2; IsoId=Q9EPR4-2; Sequence=VSP_007367, VSP_007368; Expressed in metabolically active and specialized tissues, including high expression in brain and adrenals. Detected in a wide range of tissues. Expression in kidney is almost undetectable. Phosphorylated. Note=Elevated expression levels in the adrenals of diabetic mice. Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Sequence=AAG02252.1; Type=Erroneous initiation; Evidence=; Sequence=BAA90751.1; Type=Erroneous initiation; Evidence=; Sequence=BAC65509.1; Type=Erroneous gene model prediction; Evidence=; cytoplasm plasma membrane integral component of plasma membrane ion transport sodium ion transport response to oxidative stress L-ascorbate:sodium symporter activity basal plasma membrane L-ascorbic acid transporter activity symporter activity L-ascorbic acid transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane L-ascorbic acid metabolic process transmembrane transporter activity transmembrane transport sodium-dependent L-ascorbate transmembrane transporter activity transepithelial L-ascorbic acid transport uc008mmi.1 uc008mmi.2 
ENSMUST00000028816.9 Tmem230 ENSMUST00000028816.9 transmembrane protein 230, transcript variant 1 (from RefSeq NM_027478.3) ENSMUST00000028816.1 ENSMUST00000028816.2 ENSMUST00000028816.3 ENSMUST00000028816.4 ENSMUST00000028816.5 ENSMUST00000028816.6 ENSMUST00000028816.7 ENSMUST00000028816.8 NM_027478 Q8CIB6 Q9CYF7 TM230_MOUSE uc008mmk.1 uc008mmk.2 uc008mmk.3 uc008mmk.4 Involved in trafficking and recycling of synaptic vesicles. Membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Golgi apparatus, trans-Golgi network Early endosome Recycling endosome Late endosome Cytoplasmic vesicle, autophagosome Widely expressed, including dopaminergic neurons in the substantia nigra. Belongs to the TMEM134/TMEM230 family. molecular_function endosome early endosome late endosome autophagosome endoplasmic reticulum Golgi apparatus trans-Golgi network synaptic vesicle membrane integral component of membrane cell junction cytoplasmic vesicle synapse synaptic vesicle transport recycling endosome uc008mmk.1 uc008mmk.2 uc008mmk.3 uc008mmk.4 
ENSMUST00000028817.7 Pcna ENSMUST00000028817.7 proliferating cell nuclear antigen (from RefSeq NM_011045.2) ENSMUST00000028817.1 ENSMUST00000028817.2 ENSMUST00000028817.3 ENSMUST00000028817.4 ENSMUST00000028817.5 ENSMUST00000028817.6 NM_011045 Pcna Q542J9 Q542J9_MOUSE uc008mml.1 uc008mml.2 uc008mml.3 This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Nucleus Belongs to the PCNA family. purine-specific mismatch base pair DNA N-glycosylase activity chromatin DNA binding chromatin binding damaged DNA binding nucleus nucleoplasm replication fork centrosome DNA replication regulation of DNA replication mismatch repair response to oxidative stress heart development nuclear body enzyme binding translesion synthesis estrogen receptor binding DNA polymerase processivity factor activity epithelial cell differentiation receptor tyrosine kinase binding positive regulation of deoxyribonuclease activity dinucleotide insertion or deletion binding response to estradiol MutLalpha complex binding response to lipid cellular response to UV histone acetyltransferase binding identical protein binding nuclear replication fork PCNA complex estrous cycle positive regulation of DNA repair positive regulation of DNA replication response to cadmium ion DNA polymerase binding cellular response to hydrogen peroxide PCNA-p21 complex response to dexamethasone liver regeneration response to L-glutamate uc008mml.1 uc008mml.2 uc008mml.3 
ENSMUST00000028821.10 Fsip1 ENSMUST00000028821.10 fibrous sheath-interacting protein 1, transcript variant 2 (from RefSeq NM_027759.3) ENSMUST00000028821.1 ENSMUST00000028821.2 ENSMUST00000028821.3 ENSMUST00000028821.4 ENSMUST00000028821.5 ENSMUST00000028821.6 ENSMUST00000028821.7 ENSMUST00000028821.8 ENSMUST00000028821.9 FSIP1_MOUSE NM_027759 Q8R4I9 Q9D3V5 Q9DAD8 uc008lrs.1 uc008lrs.2 uc008lrs.3 May interact with AKAP4. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D3V5-1; Sequence=Displayed; Name=2; IsoId=Q9D3V5-2; Sequence=VSP_030430, VSP_030431; Detected in male germ cells and testis. First detected in testis of 18 day old mice. Belongs to the FSIP1 family. protein binding biological_process motile cilium uc008lrs.1 uc008lrs.2 uc008lrs.3 
ENSMUST00000028825.5 Fam98b ENSMUST00000028825.5 family with sequence similarity 98, member B (from RefSeq NM_026620.3) A2ATZ4 ENSMUST00000028825.1 ENSMUST00000028825.2 ENSMUST00000028825.3 ENSMUST00000028825.4 FA98B_MOUSE NM_026620 Q80VD1 Q9CS28 Q9CS37 uc008lrk.1 uc008lrk.2 Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation. Homodimer. Component of a tRNA-splicing ligase complex. Interacts with FAM98A. Nucleus Cytoplasm Belongs to the FAM98 family. nucleus nucleoplasm cytoplasm protein methylation protein methyltransferase activity positive regulation of cell proliferation positive regulation of gene expression identical protein binding intracellular membrane-bounded organelle tRNA-splicing ligase complex uc008lrk.1 uc008lrk.2 
ENSMUST00000028826.4 Chgb ENSMUST00000028826.4 chromogranin B (from RefSeq NM_007694.5) Chgb ENSMUST00000028826.1 ENSMUST00000028826.2 ENSMUST00000028826.3 NM_007694 Q3TY66 Q3TY66_MOUSE uc008mnf.1 uc008mnf.2 uc008mnf.3 Secreted Belongs to the chromogranin/secretogranin protein family. secretory granule uc008mnf.1 uc008mnf.2 uc008mnf.3 
ENSMUST00000028829.13 Spred1 ENSMUST00000028829.13 sprouty protein with EVH-1 domain 1, related sequence, transcript variant 1 (from RefSeq NM_033524.4) ENSMUST00000028829.1 ENSMUST00000028829.10 ENSMUST00000028829.11 ENSMUST00000028829.12 ENSMUST00000028829.2 ENSMUST00000028829.3 ENSMUST00000028829.4 ENSMUST00000028829.5 ENSMUST00000028829.6 ENSMUST00000028829.7 ENSMUST00000028829.8 ENSMUST00000028829.9 NM_033524 Q3U2W6 Q6PET8 Q924S8 SPRE1_MOUSE uc008lri.1 uc008lri.2 uc008lri.3 uc008lri.4 uc008lri.5 This gene encodes a membrane-associated protein that is phosphorylated by tyrosine kinases in response to growth factors. The encoded protein acts as a negative regulator of the mitogen-activated protein (MAP) kinase signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase (PubMed:11493923). Negatively regulates hematopoiesis of bone marrow (PubMed:15465815). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (PubMed:25576668). Homodimer and heterodimer (By similarity). Able to interact with SPRED2 to form heterodimers (By similarity). Interacts (via C- terminus) with TAOK1/MARKK (via C-terminus); the interaction does not affect TAOK1 kinase activity (By similarity). Interacts (via C- terminus) with TESK1 (via C-terminus); the interaction inhibits TESK1 kinase activity (PubMed:17974561). Interacts with CAV1 (By similarity). Interacts with RAS (PubMed:11493923). Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction leads to palmitoylation of SPRED1 (PubMed:24705354). Cell membrane ; Peripheral membrane protein Membrane, caveola ; Peripheral membrane protein Nucleus Note=Localized in cholesterol-rich membrane raft/caveola fractions. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q924S8-1; Sequence=Displayed; Name=2; IsoId=Q924S8-2; Sequence=VSP_012412, VSP_012413; Expressed in brain. Weakly expressed in lung, heart, liver, kidney, intestine, spleen, testis, thymus, colon and ovary. Also expressed in embryonic tissues such as heart, lung, liver and brain. Highly expressed in IL3-dependent hematopoietic cell lines (Ba/F3 and MC/9) and bone marrow-derived mast cells (BMMC). Palmitoylated by ZDHHC17/HIP14. Ubiquitinated. Phosphorylated on tyrosine. inactivation of MAPK activity stem cell factor receptor binding protein binding nucleus cytosol plasma membrane caveola negative regulation of protein kinase activity multicellular organism development regulation of signal transduction negative regulation of peptidyl-threonine phosphorylation negative regulation of phosphatase activity membrane negative regulation of angiogenesis protein kinase binding phosphatase binding protein serine/threonine kinase inhibitor activity cytoplasmic vesicle negative regulation of MAPK cascade positive regulation of DNA damage response, signal transduction by p53 class mediator vasculogenesis involved in coronary vascular morphogenesis negative regulation of ERK1 and ERK2 cascade negative regulation of cell migration involved in sprouting angiogenesis regulation of protein deacetylation uc008lri.1 uc008lri.2 uc008lri.3 uc008lri.4 uc008lri.5 
ENSMUST00000028831.15 Mcm8 ENSMUST00000028831.15 minichromosome maintenance 8 homologous recombination repair factor, transcript variant 1 (from RefSeq NM_001291054.1) A2AVM8 A2AVM9 ENSMUST00000028831.1 ENSMUST00000028831.10 ENSMUST00000028831.11 ENSMUST00000028831.12 ENSMUST00000028831.13 ENSMUST00000028831.14 ENSMUST00000028831.2 ENSMUST00000028831.3 ENSMUST00000028831.4 ENSMUST00000028831.5 ENSMUST00000028831.6 ENSMUST00000028831.7 ENSMUST00000028831.8 ENSMUST00000028831.9 MCM8_MOUSE NM_001291054 Q3UZG5 Q80US2 Q80VI0 Q9CWV1 uc008mnj.1 uc008mnj.2 uc008mnj.3 uc008mnj.4 uc008mnj.5 Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross- links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (By similarity). Probably by regulating HR, plays a key role during gametogenesis (PubMed:22771120). Stabilizes MCM9 protein (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9. Interacts with the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1. Interacts with RAD51; the interaction recruits RAD51 to DNA damage sites. Interacts with the MRN complex composed of MRE11, RAD50 and NBN/NBS1. Interacts with CDC6 and ORC2. Interacts with HROB; the interaction recruits the MCM8-MCM9 complex to DNA damage sites (By similarity). Nucleus Chromosome Note=Localizes to nuclear foci. Localizes to double-stranded DNA breaks. Binds chromatin throughout the cell cycle. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CWV1-1; Sequence=Displayed; Name=2; IsoId=Q9CWV1-2; Sequence=VSP_015786; Mice are viable but are sterile due to defects in double-strand break repair during gametogenesis. Testes are apoptotic and contain spermatocytes that have persistent DNA damage and unsynapsed chromosomes due to defective homologous recombinatio. Ovaries are characterized by an early block of follicle development, and they later develop tumors. Belongs to the MCM family. nucleotide binding double-strand break repair via homologous recombination DNA binding DNA helicase activity chromatin binding DNA replication origin binding single-stranded DNA binding helicase activity ATP binding nucleus nucleoplasm chromosome DNA replication DNA replication initiation DNA repair cellular response to DNA damage stimulus cell cycle female gamete generation hydrolase activity enzyme binding MutLbeta complex binding MutSalpha complex binding MutSbeta complex binding DNA duplex unwinding recombinational interstrand cross-link repair MCM complex male gamete generation protein stabilization protein localization to chromatin MCM8-MCM9 complex uc008mnj.1 uc008mnj.2 uc008mnj.3 uc008mnj.4 uc008mnj.5 
ENSMUST00000028834.3 Tmco5 ENSMUST00000028834.3 transmembrane and coiled-coil domains 5, transcript variant 1 (from RefSeq NM_026104.5) A2ARB1 ENSMUST00000028834.1 ENSMUST00000028834.2 NM_026104 Q9CVN5 Q9D9D5 TMC5A_MOUSE Tmco5a uc008lre.1 uc008lre.2 uc008lre.3 uc008lre.4 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D9D5-1; Sequence=Displayed; Name=2; IsoId=Q9D9D5-2; Sequence=VSP_028248; Only detected in testis (at protein level). Detected in testis at 28 days after birth and expression is maintained (PubMed:28742876). Expressed by testicular cells and testicular sperm but not mature sperm (PubMed:28742876). Belongs to the TMCO5 family. Sequence=CAM20932.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM20933.1; Type=Erroneous gene model prediction; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008lre.1 uc008lre.2 uc008lre.3 uc008lre.4 
ENSMUST00000028835.13 Crls1 ENSMUST00000028835.13 cardiolipin synthase 1, transcript variant 1 (from RefSeq NM_001024385.1) CRLS1_MOUSE ENSMUST00000028835.1 ENSMUST00000028835.10 ENSMUST00000028835.11 ENSMUST00000028835.12 ENSMUST00000028835.2 ENSMUST00000028835.3 ENSMUST00000028835.4 ENSMUST00000028835.5 ENSMUST00000028835.6 ENSMUST00000028835.7 ENSMUST00000028835.8 ENSMUST00000028835.9 NM_001024385 Q80ZM8 Q9D4U1 uc008mnk.1 uc008mnk.2 uc008mnk.3 uc008mnk.4 Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. Reaction=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2- diacyl-sn-glycerol = a cardiolipin + CMP + H(+); Xref=Rhea:RHEA:32931, ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:60377, ChEBI:CHEBI:62237, ChEBI:CHEBI:64716; EC=2.7.8.41; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Knockout mice have severely reduced cardiolipin (CL) (diphosphatidylglycerol) in mitochondrial membranes. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. Sequence=BAB30134.1; Type=Erroneous initiation; Evidence=; mitochondrion mitochondrial inner membrane lipid metabolic process phospholipid biosynthetic process cardiolipin synthase activity membrane integral component of membrane transferase activity phosphotransferase activity, for other substituted phosphate groups mitochondrial membrane cardiolipin biosynthetic process glycerophospholipid biosynthetic process response to thyroxine response to phosphatidylethanolamine uc008mnk.1 uc008mnk.2 uc008mnk.3 uc008mnk.4 
ENSMUST00000028836.7 Bmp2 ENSMUST00000028836.7 bone morphogenetic protein 2 (from RefSeq NM_007553.3) BMP2_MOUSE Bmp-2 ENSMUST00000028836.1 ENSMUST00000028836.2 ENSMUST00000028836.3 ENSMUST00000028836.4 ENSMUST00000028836.5 ENSMUST00000028836.6 NM_007553 P21274 Q497W8 uc008mnr.1 uc008mnr.2 uc008mnr.3 uc008mnr.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. While a homozygous knockout mouse for this gene exhibits embryonic lethality, conditional knockout mice have defects in bone, cartilage and heart development. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133923.1, AK132433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3 (PubMed:31800957). Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (PubMed:29148101). Homodimer; disulfide-linked. Interacts with SOSTDC1 (By similarity). Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN (By similarity). Interacts with MAFP5 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2. Interacts with type I receptor BMPR1A. Interacts with type II receptor BMPR2 (By similarity). Interacts with SCUBE3 (By similarity). Interacts with TNFAIP6 (primarily via Link domain); this interaction is inhibited by hyaluronan. Interacts with ERFE (PubMed:31800957). Interacts with BMPR1A/ALK3; the interaction may induce HAMP expression (PubMed:31800957). Forms heterodimers with BMP6 in vitro; the heterodimer then binds to its receptor BMPR1A /ALK3 and may induce HAMP expression (PubMed:31800957). Secreted. Expressed in early bell stage dental mesenchymal cells at 15.5 dpc (at protein level) (PubMed:24028588). Expressed in bell stage dental mesenchymal cells at 17.5 dpc (at protein level) (PubMed:29148101). Heterozygous BMP2-knockout mice show abnormal numbers of rib pairs, a reduction in overall body length, and less bone mineral content and volume than wild-type mice. Homozygous BMP2- knockout mice die before embryonic day 12.5. Belongs to the TGF-beta family. negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity ossification osteoblast differentiation branching involved in ureteric bud morphogenesis response to hypoxia in utero embryonic development epithelial to mesenchymal transition positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation chondrocyte differentiation BMP signaling pathway involved in heart induction atrioventricular valve morphogenesis endocardial cushion morphogenesis negative regulation of Wnt signaling pathway involved in heart development retinol dehydrogenase activity cytokine activity transforming growth factor beta receptor binding protein binding extracellular region extracellular space cytoplasm proteoglycan metabolic process regulation of transcription, DNA-templated protein phosphorylation inflammatory response transforming growth factor beta receptor signaling pathway Notch signaling pathway multicellular organism development heart development growth factor activity negative regulation of cell proliferation response to bacterium animal organ morphogenesis cell surface positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of steroid biosynthetic process positive regulation of phosphatase activity phosphatase activator activity protein domain specific binding telencephalon development telencephalon regionalization cell differentiation positive regulation of Wnt signaling pathway bone mineralization positive regulation of cell migration positive regulation of bone mineralization BMP signaling pathway protein destabilization vesicle positive regulation of protein binding negative regulation of aldosterone biosynthetic process macromolecular complex positive regulation of osteoblast proliferation cardiocyte differentiation embryonic heart tube anterior/posterior pattern specification bone mineralization involved in bone maturation co-receptor binding odontogenesis of dentin-containing tooth positive regulation of odontogenesis regulation of odontogenesis of dentin-containing tooth protein homodimerization activity regulation of apoptotic process positive regulation of apoptotic process intracellular membrane-bounded organelle regulation of MAPK cascade positive regulation of MAPK cascade negative regulation of insulin-like growth factor receptor signaling pathway cell fate commitment positive regulation of cell differentiation positive regulation of fat cell differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter SMAD binding protein heterodimerization activity cell development positive regulation of astrocyte differentiation mesenchymal cell differentiation inner ear development positive regulation of neurogenesis negative regulation of calcium-independent cell-cell adhesion cartilage development cardiac muscle cell differentiation cardiac muscle tissue morphogenesis oxidation-reduction process pericardium development corticotropin hormone secreting cell differentiation thyroid-stimulating hormone-secreting cell differentiation cardiac epithelial to mesenchymal transition pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction mesenchyme development positive regulation of Wnt signaling pathway by BMP signaling pathway positive regulation of cartilage development positive regulation of ERK1 and ERK2 cascade BMP receptor binding BMP receptor complex cellular response to growth factor stimulus cellular response to organic cyclic compound cellular response to BMP stimulus mesenchymal cell proliferation involved in ureteric bud development negative regulation of canonical Wnt signaling pathway positive regulation of p38MAPK cascade positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of cortisol biosynthetic process negative regulation of cardiac muscle cell differentiation uc008mnr.1 uc008mnr.2 uc008mnr.3 uc008mnr.4 
ENSMUST00000028838.5 Hdc ENSMUST00000028838.5 histidine decarboxylase (from RefSeq NM_008230.6) DCHS_MOUSE ENSMUST00000028838.1 ENSMUST00000028838.2 ENSMUST00000028838.3 ENSMUST00000028838.4 NM_008230 P23738 Q9QWU3 uc008mdr.1 uc008mdr.2 uc008mdr.3 uc008mdr.4 uc008mdr.5 Catalyzes the biosynthesis of histamine from histidine. Reaction=H(+) + L-histidine = CO2 + histamine; Xref=Rhea:RHEA:20840, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57595, ChEBI:CHEBI:58432; EC=4.1.1.22; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1. Homodimer. Belongs to the group II decarboxylase family. histamine metabolic process histamine biosynthetic process catalytic activity histidine decarboxylase activity cytosol cellular amino acid metabolic process histidine metabolic process histidine catabolic process amino acid binding lyase activity carboxy-lyase activity carboxylic acid metabolic process pyridoxal phosphate binding dendrite catecholamine biosynthetic process protein homodimerization activity neuronal cell body uc008mdr.1 uc008mdr.2 uc008mdr.3 uc008mdr.4 uc008mdr.5 
ENSMUST00000028841.14 Usp8 ENSMUST00000028841.14 ubiquitin specific peptidase 8, transcript variant 7 (from RefSeq NR_185498.1) A2AI53 ENSMUST00000028841.1 ENSMUST00000028841.10 ENSMUST00000028841.11 ENSMUST00000028841.12 ENSMUST00000028841.13 ENSMUST00000028841.2 ENSMUST00000028841.3 ENSMUST00000028841.4 ENSMUST00000028841.5 ENSMUST00000028841.6 ENSMUST00000028841.7 ENSMUST00000028841.8 ENSMUST00000028841.9 Kiaa0055 NR_185498 Q80U87 Q80YP2 Q8R0D3 Q9EQU1 Q9WVP5 UBP8_MOUSE Ubpy Usp8 uc008meb.1 uc008meb.2 uc008meb.3 uc008meb.4 Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1 (By similarity). Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Forms a ternary complex with RNF128 and OTUB1. Interacts (via C-terminal UCH catalytic domain) with OTUB1 isoform 1. Interacts with STAM2 (via SH3 domain). Interacts with DNAJB3, EGFR, EPS15, RASGRF1, RNF41, YWHAE, YWHAG and YWHAZ. Interacts with NBR1, RASGRF1, RNF41 and IST1 (By similarity). Associates with the ESCRT-0 complex and with microtubules. Interacts with BIRC6/bruce and KIF23/MKLP1. Cytoplasm Nucleus Endosome membrane ; Peripheral membrane protein Cell membrane ; Peripheral membrane protein Highly expressed in testis. Expressed at intermediate level in brain. The MIT domain is required for endosomal localization, CHMP1B- binding, maintenance of ESCRT-0 stability and EGFR degradation. The rhodanese domain is sufficient for RNF41-binding. Phosphorylation of Ser-680 is essential for interaction with YWHAE and for cytosol localization. Undergoes dephosphorylation at Ser-680 in the M phase. Tyrosine-phosphorylated in its N-terminal half in an EGFR- dependent manner. Ubiquitinated. Inactive form is mostly monoubiquitinated, but polyubiquitination happens too. Ubiquitination is increased in EGF- stimulated cells. Ubiquitination of active form is undetectable, suggesting a possibility that USP8 deubiquitinates itself, thereby regulating its own function. Belongs to the peptidase C19 family. Sequence=BAC65477.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; mitotic cytokinesis thiol-dependent ubiquitin-specific protease activity protein binding nucleus cytoplasm endosome early endosome cytosol plasma membrane proteolysis ubiquitin-dependent protein catabolic process endosome organization cell cycle Ras protein signal transduction peptidase activity cysteine-type peptidase activity endosome membrane postsynaptic density membrane protein deubiquitination hydrolase activity SH3 domain binding extrinsic component of plasma membrane midbody extrinsic component of endosome membrane regulation of protein stability regulation of protein localization thiol-dependent ubiquitinyl hydrolase activity dendritic spine protein K63-linked deubiquitination protein K48-linked deubiquitination positive regulation of canonical Wnt signaling pathway glutamatergic synapse regulation of protein catabolic process at postsynapse, modulating synaptic transmission cellular response to nerve growth factor stimulus acrosomal vesicle uc008meb.1 uc008meb.2 uc008meb.3 uc008meb.4 
ENSMUST00000028842.9 Usp50 ENSMUST00000028842.9 ubiquitin specific peptidase 50 (from RefSeq NM_029163.3) ENSMUST00000028842.1 ENSMUST00000028842.2 ENSMUST00000028842.3 ENSMUST00000028842.4 ENSMUST00000028842.5 ENSMUST00000028842.6 ENSMUST00000028842.7 ENSMUST00000028842.8 NM_029163 Q6P8X6 Q9D558 Q9D9E7 UBP50_MOUSE uc008mee.1 uc008mee.2 uc008mee.3 uc008mee.4 May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P8X6-1; Sequence=Displayed; Name=2; IsoId=Q6P8X6-2; Sequence=VSP_020486, VSP_020487; The human ortholog is inactive. Belongs to the peptidase C19 family. thiol-dependent ubiquitin-specific protease activity protein binding cytosol proteolysis ubiquitin-dependent protein catabolic process endosome organization Ras protein signal transduction peptidase activity cysteine-type peptidase activity postsynaptic density protein deubiquitination hydrolase activity ubiquitin-like protein-specific protease activity extrinsic component of plasma membrane midbody extrinsic component of endosome membrane positive regulation of protein homooligomerization positive regulation of interleukin-18 production thiol-dependent ubiquitinyl hydrolase activity dendritic spine positive regulation of interleukin-1 beta secretion protein K63-linked deubiquitination protein K48-linked deubiquitination positive regulation of NLRP3 inflammasome complex assembly positive regulation of cysteine-type endopeptidase activity uc008mee.1 uc008mee.2 uc008mee.3 uc008mee.4 
ENSMUST00000028844.11 Sppl2a ENSMUST00000028844.11 signal peptide peptidase like 2A (from RefSeq NM_023220.2) A2AI51 ENSMUST00000028844.1 ENSMUST00000028844.10 ENSMUST00000028844.2 ENSMUST00000028844.3 ENSMUST00000028844.4 ENSMUST00000028844.5 ENSMUST00000028844.6 ENSMUST00000028844.7 ENSMUST00000028844.8 ENSMUST00000028844.9 Imp3 MNCb-3763 NM_023220 Psl2 Q8R354 Q9JJF9 SPP2A_MOUSE Sppl2a uc008mej.1 uc008mej.2 uc008mej.3 uc008mej.4 Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). Essential for degradation of the invariant chain CD74 that plays a central role in the function of antigen-presenting cells in the immune system. Plays a role in the regulation of innate and adaptive immunity. Interacts with ITM2B. Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Membrane ; Multi-pass membrane protein ; Lumenal side Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane. The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP (By similarity). The C-terminal tail is necessary for lysosomal transport (PubMed:21896273). Glycosylated. Knockout mice increase susceptibility to mycobacterial infection after BCG administration compared to wild-type mice. Mutant animals have decreased numbers of DC2 dendritic cells (cDC2), a smaller sized IFNG+ CD4+ and CD8+ T cell fraction, and decreased production of IFNG by splenocytes compared to wild-type animals. They also have profound B cell deficiency due to CD74 NTF accumulation. The protein is required for optimal IFNG production by T cells after mycobacterial infection (PubMed:30127434). Mutant mice confirm depletion of conventional cDC2 cells in lymphatic tissues of null mice. Detailed studies of bone marrow-derived dendritic cells exposed to mycobacteria show enhanced secretion of Il1b, where production of Il10 and Ifnb1 is reduced. There are also some alterations in stimulation of pattern recognition receptors (PubMed:33239420). Belongs to the peptidase A22B family. aspartic-type endopeptidase activity lysosome lysosomal membrane endosome late endosome plasma membrane proteolysis membrane protein ectodomain proteolysis peptidase activity membrane integral component of membrane hydrolase activity Golgi-associated vesicle membrane membrane protein intracellular domain proteolysis late endosome membrane membrane protein proteolysis aspartic endopeptidase activity, intramembrane cleaving protein homodimerization activity intracellular membrane-bounded organelle regulation of immune response integral component of cytoplasmic side of endoplasmic reticulum membrane integral component of lumenal side of endoplasmic reticulum membrane uc008mej.1 uc008mej.2 uc008mej.3 uc008mej.4 
ENSMUST00000028846.7 Dusp2 ENSMUST00000028846.7 dual specificity phosphatase 2 (from RefSeq NM_010090.2) DUS2_MOUSE Dusp2 ENSMUST00000028846.1 ENSMUST00000028846.2 ENSMUST00000028846.3 ENSMUST00000028846.4 ENSMUST00000028846.5 ENSMUST00000028846.6 NM_010090 Pac-1 Pac1 Q05922 Q60640 Q80ZN1 uc008mff.1 uc008mff.2 uc008mff.3 Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine (PubMed:16288922). Can dephosphorylate MAPK1 (PubMed:16288922). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10685; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47005; Evidence=; Interacts with MAPK14; this interaction does not lead to catalytic activation of DUSP2 and dephosphrylation of MAPK14. Q05922; P28482: MAPK1; Xeno; NbExp=2; IntAct=EBI-7898692, EBI-959949; Nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=Q05922-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q05922-2; Sequence=VSP_005135, VSP_005136; In hematopoietic tissues such as spleen and thymus. By mitogens. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. inactivation of MAPK activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding nucleus cytoplasm protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity nuclear membrane peptidyl-tyrosine dephosphorylation mitogen-activated protein kinase binding uc008mff.1 uc008mff.2 uc008mff.3 
ENSMUST00000028848.4 Fahd2a ENSMUST00000028848.4 fumarylacetoacetate hydrolase domain containing 2A (from RefSeq NM_029629.2) A0A0R4J094 A0A0R4J094_MOUSE ENSMUST00000028848.1 ENSMUST00000028848.2 ENSMUST00000028848.3 Fahd2a NM_029629 uc008mfk.1 uc008mfk.2 uc008mfk.3 uc008mfk.4 May have hydrolase activity. Belongs to the FAH family. catalytic activity uc008mfk.1 uc008mfk.2 uc008mfk.3 uc008mfk.4 
ENSMUST00000028852.13 Mrps5 ENSMUST00000028852.13 mitochondrial ribosomal protein S5 (from RefSeq NM_029963.2) ENSMUST00000028852.1 ENSMUST00000028852.10 ENSMUST00000028852.11 ENSMUST00000028852.12 ENSMUST00000028852.2 ENSMUST00000028852.3 ENSMUST00000028852.4 ENSMUST00000028852.5 ENSMUST00000028852.6 ENSMUST00000028852.7 ENSMUST00000028852.8 ENSMUST00000028852.9 NM_029963 Q99N87 RT05_MOUSE uc008mfu.1 uc008mfu.2 uc008mfu.3 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uS5 family. RNA binding structural constituent of ribosome mitochondrion mitochondrial small ribosomal subunit ribosome translation uc008mfu.1 uc008mfu.2 uc008mfu.3 
ENSMUST00000028854.15 Mal ENSMUST00000028854.15 myelin and lymphocyte protein, T cell differentiation protein, transcript variant 1 (from RefSeq NM_010762.5) ENSMUST00000028854.1 ENSMUST00000028854.10 ENSMUST00000028854.11 ENSMUST00000028854.12 ENSMUST00000028854.13 ENSMUST00000028854.14 ENSMUST00000028854.2 ENSMUST00000028854.3 ENSMUST00000028854.4 ENSMUST00000028854.5 ENSMUST00000028854.6 ENSMUST00000028854.7 ENSMUST00000028854.8 ENSMUST00000028854.9 MAL_MOUSE NM_010762 O08819 O09109 O09198 Q545Q7 Q9D2R2 uc008mfv.1 uc008mfv.2 uc008mfv.3 This gene encodes a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The encoded protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Plays a role in the maintenance of the myelin sheath and in axon-glia and glia-glia interactions. Golgi apparatus membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Found in lipid raft. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A; IsoId=O09198-1; Sequence=Displayed; Name=2; Synonyms=C; IsoId=O09198-2; Sequence=VSP_031253; Expressed in the spinal cord, brain, kidney and gastrointestinal tract especially in the stomach and caecum. Highly expressed by myelinating glial cells. Lipoprotein. Abnormal myelination and optic nerve morphology. Belongs to the MAL family. Golgi membrane protein localization to paranode region of axon endoplasmic reticulum Golgi apparatus plasma membrane membrane integral component of membrane apical plasma membrane extrinsic component of membrane structural constituent of myelin sheath myelination plasma membrane raft membrane raft protein insertion into plasma membrane positive regulation of extrinsic apoptotic signaling pathway via death domain receptors uc008mfv.1 uc008mfv.2 uc008mfv.3 
ENSMUST00000028855.14 Prom2 ENSMUST00000028855.14 prominin 2, transcript variant 1 (from RefSeq NM_138750.2) A2AHT1 ENSMUST00000028855.1 ENSMUST00000028855.10 ENSMUST00000028855.11 ENSMUST00000028855.12 ENSMUST00000028855.13 ENSMUST00000028855.2 ENSMUST00000028855.3 ENSMUST00000028855.4 ENSMUST00000028855.5 ENSMUST00000028855.6 ENSMUST00000028855.7 ENSMUST00000028855.8 ENSMUST00000028855.9 NM_138750 PROM2_MOUSE Proml2 Q3UUY6 Q8CDM5 Q8CHT5 Q8R4Y7 Q9WUC7 uc008mfp.1 uc008mfp.2 uc008mfp.3 uc008mfp.4 Binds cholesterol. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein. Cell projection, cilium membrane; Multi-pass membrane protein. Note=Colocalizes with PROM1 (By similarity). Associates with membrane in a cholesterol-dependent manner. Localizes to the apical and basolateral membranes of epithelial cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UUY6-1; Sequence=Displayed; Name=2; IsoId=Q3UUY6-2; Sequence=VSP_033150; Expressed in kidney and testis. Present in urine within small membrane particles (at protein level). In the submandibular gland, expressed in seromucous acini. In the parotid gland, expressed in the serous acini and in all segments of the duct system. In the sublingual gland, expressed in large excretory ducts, but absent in intercalated ducts. In the extraorbital lacrimal gland, expressed in the serous acini. In the eyelid, expressed in the acini of the meibomian gland. Glycosylated. Belongs to the prominin family. Sequence=BAC26644.1; Type=Frameshift; Evidence=; positive regulation of protein phosphorylation plasma membrane integral component of plasma membrane microvillus cilium cell surface cholesterol binding membrane integral component of membrane basolateral plasma membrane apical plasma membrane positive regulation of cell projection organization cytoplasmic vesicle microvillus membrane cell projection regulation of GTPase activity microspike negative regulation of pinocytosis ciliary membrane prominosome negative regulation of caveolin-mediated endocytosis membrane raft uc008mfp.1 uc008mfp.2 uc008mfp.3 uc008mfp.4 
ENSMUST00000028856.3 Mall ENSMUST00000028856.3 mal, T cell differentiation protein-like (from RefSeq NM_145532.3) Bene ENSMUST00000028856.1 ENSMUST00000028856.2 MALL_MOUSE NM_145532 Q3TQ65 Q91X49 uc008mfx.1 uc008mfx.2 uc008mfx.3 Membrane ; Multi-pass membrane protein Belongs to the MAL family. Golgi membrane plasma membrane membrane integral component of membrane structural constituent of myelin sheath clathrin-coated vesicle cytoplasmic vesicle myelination membrane raft uc008mfx.1 uc008mfx.2 uc008mfx.3 
ENSMUST00000028857.14 Nphp1 ENSMUST00000028857.14 nephronophthisis 1 (juvenile) homolog (human), transcript variant 1 (from RefSeq NM_016902.4) A2APS1 A2APS1_MOUSE ENSMUST00000028857.1 ENSMUST00000028857.10 ENSMUST00000028857.11 ENSMUST00000028857.12 ENSMUST00000028857.13 ENSMUST00000028857.2 ENSMUST00000028857.3 ENSMUST00000028857.4 ENSMUST00000028857.5 ENSMUST00000028857.6 ENSMUST00000028857.7 ENSMUST00000028857.8 ENSMUST00000028857.9 NM_016902 Nphp1 uc008mga.1 uc008mga.2 uc008mga.3 uc008mga.4 cell-cell junction motile cilium positive regulation of bicellular tight junction assembly uc008mga.1 uc008mga.2 uc008mga.3 uc008mga.4 
ENSMUST00000028858.9 Bub1 ENSMUST00000028858.9 BUB1, mitotic checkpoint serine/threonine kinase, transcript variant 1 (from RefSeq NM_001113179.1) A2APR8 A2APR8_MOUSE Bub1 ENSMUST00000028858.1 ENSMUST00000028858.2 ENSMUST00000028858.3 ENSMUST00000028858.4 ENSMUST00000028858.5 ENSMUST00000028858.6 ENSMUST00000028858.7 ENSMUST00000028858.8 NM_001113179 uc008mge.1 uc008mge.2 uc008mge.3 uc008mge.4 uc008mge.5 kinetochore condensed chromosome kinetochore condensed nuclear chromosome outer kinetochore protein kinase activity ATP binding nucleoplasm cytosol protein phosphorylation regulation of sister chromatid cohesion mitotic spindle assembly checkpoint cell proliferation regulation of chromosome segregation uc008mge.1 uc008mge.2 uc008mge.3 uc008mge.4 uc008mge.5 
ENSMUST00000028859.8 Acoxl ENSMUST00000028859.8 acyl-Coenzyme A oxidase-like (from RefSeq NM_028765.3) ACOXL_MOUSE ENSMUST00000028859.1 ENSMUST00000028859.2 ENSMUST00000028859.3 ENSMUST00000028859.4 ENSMUST00000028859.5 ENSMUST00000028859.6 ENSMUST00000028859.7 NM_028765 Q80ZM1 Q9DBS4 uc008mgg.1 uc008mgg.2 uc008mgg.3 uc008mgg.4 uc008mgg.5 Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DBS4-1; Sequence=Displayed; Name=2; IsoId=Q9DBS4-2; Sequence=VSP_028240; Belongs to the acyl-CoA oxidase family. acyl-CoA oxidase activity fatty acid binding peroxisome fatty acid metabolic process fatty acid beta-oxidation oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors fatty acid beta-oxidation using acyl-CoA oxidase flavin adenine dinucleotide binding lipid homeostasis oxidation-reduction process FAD binding uc008mgg.1 uc008mgg.2 uc008mgg.3 uc008mgg.4 uc008mgg.5 
ENSMUST00000028866.9 Zc3h8 ENSMUST00000028866.9 zinc finger CCCH type containing 8 (from RefSeq NM_020594.2) ENSMUST00000028866.1 ENSMUST00000028866.2 ENSMUST00000028866.3 ENSMUST00000028866.4 ENSMUST00000028866.5 ENSMUST00000028866.6 ENSMUST00000028866.7 ENSMUST00000028866.8 Fliz1 NM_020594 Q80X92 Q9JJ48 ZC3H8_MOUSE Zc3hdc8 uc033hqb.1 uc033hqb.2 uc033hqb.3 Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Acts as a transcriptional repressor of the GATA3 promoter. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis (By similarity). Sequence-specific DNA-binding factor that binds to the 5'- AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via C-terminus domain) (By similarity). Nucleus Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes (By similarity). Highly expressed in heart, muscle, testis, kidney, brain, liver, lung and spleen. The N-terminal region and all three C3H1-type zinc fingers are necessary to induce transcriptional repression. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, sequence-specific DNA binding RNA binding nucleus nucleoplasm apoptotic process transcription elongation factor complex Cajal body nuclear body negative regulation of T cell differentiation in thymus transcriptionally active chromatin histone locus body snRNA transcription from RNA polymerase II promoter snRNA transcription from RNA polymerase III promoter T cell homeostasis sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase III promoter response to antibiotic metal ion binding positive regulation of thymocyte apoptotic process uc033hqb.1 uc033hqb.2 uc033hqb.3 
ENSMUST00000028880.10 Slc20a1 ENSMUST00000028880.10 solute carrier family 20, member 1, transcript variant 5 (from RefSeq NR_185226.1) A2AKR9 ENSMUST00000028880.1 ENSMUST00000028880.2 ENSMUST00000028880.3 ENSMUST00000028880.4 ENSMUST00000028880.5 ENSMUST00000028880.6 ENSMUST00000028880.7 ENSMUST00000028880.8 ENSMUST00000028880.9 Glvr1 NR_185226 Pit1 Q3U244 Q61609 Q8CBJ1 Q91YQ9 Q9QVW6 S20A1_MOUSE uc008mhl.1 uc008mhl.2 uc008mhl.3 uc008mhl.4 uc008mhl.5 Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Essential for cell proliferation but this function is independent of its phosphate transporter activity. (Microbial infection) May function as a retroviral receptor but do not confer infection susceptibility to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B). Reaction=2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in); Xref=Rhea:RHEA:71259, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; Evidence=; Cell membrane ; Multi-pass membrane protein Ubiquitously expressed. Detected at 17 dpc of embryonic development in a subpopulation of early hypertrophic chondrocytes in bone, but not when fully differentiated. By growth hormone. Region A does not confer susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV- B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Sequence=BAC29234.1; Type=Miscellaneous discrepancy; Note=Intron retention. The sequence differs at the 3'end due to intron retention.; Evidence=; inorganic phosphate transmembrane transporter activity high-affinity inorganic phosphate:sodium symporter activity plasma membrane integral component of plasma membrane sodium ion transport phosphate ion transport symporter activity sodium:inorganic phosphate symporter activity membrane integral component of membrane biomineral tissue development phosphate ion transmembrane transport sodium ion transmembrane transport uc008mhl.1 uc008mhl.2 uc008mhl.3 uc008mhl.4 uc008mhl.5 
ENSMUST00000028881.14 Il1b ENSMUST00000028881.14 interleukin 1 beta (from RefSeq NM_008361.4) ENSMUST00000028881.1 ENSMUST00000028881.10 ENSMUST00000028881.11 ENSMUST00000028881.12 ENSMUST00000028881.13 ENSMUST00000028881.2 ENSMUST00000028881.3 ENSMUST00000028881.4 ENSMUST00000028881.5 ENSMUST00000028881.6 ENSMUST00000028881.7 ENSMUST00000028881.8 ENSMUST00000028881.9 IL1B_MOUSE NM_008361 P10749 Q2M4J6 uc008mht.1 uc008mht.2 uc008mht.3 uc008mht.4 The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1. The encoded protein plays a role in thymocyte proliferation and is involved in the inflammatory response. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225002.1, M15131.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. Monomer. Interacts with MEFV. Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling. Interacts with cargo receptor TMED10; the interaction is direct and is required for the secretion of IL1B mature form (By similarity). Interacts with HSP90AB1; the interaction facilitates cargo translocation into the ERGIC (By similarity). Interacts with HSP90B1; the interaction facilitates cargo translocation into the ERGIC (By similarity). Cytoplasm, cytosol Secreted Lysosome Secreted, extracellular exosome Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10. Expressed in activated macrophages (at protein level). By LPS. IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated. Belongs to the IL-1 family. negative regulation of transcription from RNA polymerase II promoter MAPK cascade activation of MAPK activity fever generation positive regulation of protein phosphorylation cytokine activity interleukin-1 receptor binding integrin binding extracellular region extracellular space cytoplasm lysosome autophagosome cytosol inflammatory response immune response positive regulation of cytosolic calcium ion concentration memory positive regulation of cell proliferation negative regulation of cell proliferation response to carbohydrate positive regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of glucose transport positive regulation of cell death negative regulation of glutamate secretion cytokine-mediated signaling pathway protein domain specific binding secretory granule hyaluronan biosynthetic process positive regulation of cell migration neutrophil chemotaxis sequestering of triglyceride positive regulation of prostaglandin biosynthetic process cytoplasmic vesicle positive regulation of fever generation lipopolysaccharide-mediated signaling pathway vesicle positive regulation of prostaglandin secretion response to lipopolysaccharide interleukin-1 beta production interleukin-6 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of stress-activated MAPK cascade positive regulation of immature T cell proliferation in thymus response to ATP positive regulation of heterotypic cell-cell adhesion social behavior ectopic germ cell programmed cell death positive regulation of myosin light chain kinase activity cellular response to drug positive regulation of T cell proliferation positive regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity protein kinase B signaling positive regulation of JUN kinase activity positive regulation of neuron apoptotic process positive regulation of chemokine biosynthetic process positive regulation of interleukin-2 biosynthetic process positive regulation of interleukin-6 biosynthetic process positive regulation of nitric oxide biosynthetic process negative regulation of neuron differentiation positive regulation of glial cell differentiation positive regulation of angiogenesis negative regulation of lipid metabolic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of complement activation positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade negative regulation of insulin receptor signaling pathway astrocyte activation positive regulation of astrocyte differentiation regulation of defense response to virus by host positive regulation of inflammatory response positive regulation of phagocytosis regulation of neurogenesis negative regulation of neurogenesis regulation of insulin secretion negative regulation of synaptic transmission leukocyte migration negative regulation of lipid catabolic process positive regulation of lipid catabolic process regulation of nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of cell division positive regulation of glial cell proliferation positive regulation of calcidiol 1-monooxygenase activity extracellular exosome negative regulation of adiponectin secretion regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade monocyte aggregation response to interleukin-1 cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to organic substance cellular response to organic cyclic compound positive regulation of monocyte chemotactic protein-1 production positive regulation of neutrophil chemotaxis extrinsic apoptotic signaling pathway in absence of ligand positive regulation of p38MAPK cascade positive regulation of NIK/NF-kappaB signaling positive regulation of RNA biosynthetic process regulation of establishment of endothelial barrier negative regulation of gap junction assembly negative regulation of branching morphogenesis of a nerve negative regulation of neural precursor cell proliferation positive regulation of T-helper 1 cell cytokine production positive regulation of interleukin-6 secretion negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc008mht.1 uc008mht.2 uc008mht.3 uc008mht.4 
ENSMUST00000028882.2 Il1a ENSMUST00000028882.2 interleukin 1 alpha (from RefSeq NM_010554.4) ENSMUST00000028882.1 Il1a NM_010554 Q3U0Y6 Q3U0Y6_MOUSE uc008mhs.1 uc008mhs.2 Monomer. Cytoplasm Nucleus Secreted Belongs to the IL-1 family. fever generation cytokine activity interleukin-1 receptor binding copper ion binding extracellular region extracellular space cytosol inflammatory response immune response negative regulation of cell proliferation positive regulation of gene expression cytokine-mediated signaling pathway cellular response to heat positive regulation of interleukin-2 biosynthetic process positive regulation of mitotic nuclear division response to copper ion positive regulation of protein secretion positive regulation of cytokine secretion positive regulation of cell division uc008mhs.1 uc008mhs.2 
ENSMUST00000028883.12 Pdyn ENSMUST00000028883.12 prodynorphin, transcript variant 1 (from RefSeq NM_018863.4) ENSMUST00000028883.1 ENSMUST00000028883.10 ENSMUST00000028883.11 ENSMUST00000028883.2 ENSMUST00000028883.3 ENSMUST00000028883.4 ENSMUST00000028883.5 ENSMUST00000028883.6 ENSMUST00000028883.7 ENSMUST00000028883.8 ENSMUST00000028883.9 NM_018863 O35852 O35852_MOUSE Pdyn uc008mid.1 uc008mid.2 uc008mid.3 uc008mid.4 uc008mid.5 This gene encodes a preproprotein that is proteolytically cleaved to yield a number of active opium-like peptides. These peptides are the endogenous ligands for the Kappa-opioid receptor and similar G-protein-coupled receptors and are thought to function as the body's natural way to control addiction. These peptides have been associated with depression, stress, anxiety, response to pain, and maintenance of homeostasis via circadian rhythms and control of appetite. Mutations in the related human gene have been linked to the neurodegenerative disease spinocerebellar ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]. Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin. Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Leumorphin has a typical opioid activity and may have anti- apoptotic effect. Secreted Belongs to the opioid neuropeptide precursor family. opioid peptide activity extracellular region plasma membrane neuropeptide signaling pathway uc008mid.1 uc008mid.2 uc008mid.3 uc008mid.4 uc008mid.5 
ENSMUST00000028888.5 Tgm6 ENSMUST00000028888.5 transglutaminase 6, transcript variant 1 (from RefSeq NM_177726.5) ENSMUST00000028888.1 ENSMUST00000028888.2 ENSMUST00000028888.3 ENSMUST00000028888.4 NM_177726 Q8BM11 Q8BM11_MOUSE Tgm6 uc008mii.1 uc008mii.2 uc008mii.3 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Belongs to the transglutaminase superfamily. Transglutaminase family. protein-glutamine gamma-glutamyltransferase activity cytoplasm peptide cross-linking metal ion binding uc008mii.1 uc008mii.2 uc008mii.3 
ENSMUST00000028892.11 Idh3b ENSMUST00000028892.11 isocitrate dehydrogenase 3 (NAD+) beta, transcript variant 1 (from RefSeq NM_130884.4) ENSMUST00000028892.1 ENSMUST00000028892.10 ENSMUST00000028892.2 ENSMUST00000028892.3 ENSMUST00000028892.4 ENSMUST00000028892.5 ENSMUST00000028892.6 ENSMUST00000028892.7 ENSMUST00000028892.8 ENSMUST00000028892.9 Idh3b NM_130884 Q91VA7 Q91VA7_MOUSE uc008min.1 uc008min.2 uc008min.3 uc008min.4 Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer. Mitochondrion Belongs to the isocitrate and isopropylmalate dehydrogenases family. magnesium ion binding isocitrate dehydrogenase (NAD+) activity mitochondrion tricarboxylic acid cycle isocitrate metabolic process 2-oxoglutarate metabolic process NADH metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor NAD binding oxidation-reduction process uc008min.1 uc008min.2 uc008min.3 uc008min.4 
ENSMUST00000028897.8 Cpxm1 ENSMUST00000028897.8 carboxypeptidase X, M14 family member 1 (from RefSeq NM_019696.2) A2BI86 CPXM1_MOUSE Cpx1 Cpxm ENSMUST00000028897.1 ENSMUST00000028897.2 ENSMUST00000028897.3 ENSMUST00000028897.4 ENSMUST00000028897.5 ENSMUST00000028897.6 ENSMUST00000028897.7 NM_019696 Q99LA3 Q9Z100 uc008mir.1 uc008mir.2 uc008mir.3 uc008mir.4 May be involved in cell-cell interactions. No carboxypeptidase activity was found yet. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted Strongly expressed in testis and spleen. Moderately expressed in salivary gland, brain, heart, lung, and kidney. Extremely low expression in liver and muscle. No expression in eye, adrenal, and white adipose tissues. First expressed at 13.5 dpc, in the meninges, nasal mesenchyme, primordial cartilage and skeletal structures. Belongs to the peptidase M14 family. metallocarboxypeptidase activity extracellular region extracellular space peptide metabolic process zinc ion binding protein processing hydrolase activity metal ion binding carboxypeptidase activity proteolysis uc008mir.1 uc008mir.2 uc008mir.3 uc008mir.4 
ENSMUST00000028900.11 Vps16 ENSMUST00000028900.11 VSP16 CORVET/HOPS core subunit, transcript variant 4 (from RefSeq NR_156014.1) ENSMUST00000028900.1 ENSMUST00000028900.10 ENSMUST00000028900.2 ENSMUST00000028900.3 ENSMUST00000028900.4 ENSMUST00000028900.5 ENSMUST00000028900.6 ENSMUST00000028900.7 ENSMUST00000028900.8 ENSMUST00000028900.9 G3X8X7 G3X8X7_MOUSE NR_156014 Vps16 uc008mja.1 uc008mja.2 uc008mja.3 uc008mja.4 Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Early endosome Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. Belongs to the VPS16 family. cytoplasm lysosome lysosomal membrane endosome early endosome late endosome intracellular protein transport vacuole organization endosome to lysosome transport protein transport membrane axon HOPS complex late endosome membrane CORVET complex neuronal cell body actin filament binding recycling endosome autophagosome maturation uc008mja.1 uc008mja.2 uc008mja.3 uc008mja.4 
ENSMUST00000028902.3 Otor ENSMUST00000028902.3 otoraplin (from RefSeq NM_020595.3) ENSMUST00000028902.1 ENSMUST00000028902.2 Mial NM_020595 OTOR_MOUSE Q9JIE3 uc008mqc.1 uc008mqc.2 uc008mqc.3 uc008mqc.4 Secreted Highly expressed in cochlea. Belongs to the MIA/OTOR family. cartilage condensation extracellular region Golgi apparatus uc008mqc.1 uc008mqc.2 uc008mqc.3 uc008mqc.4 
ENSMUST00000028905.10 Pcsk2 ENSMUST00000028905.10 proprotein convertase subtilisin/kexin type 2 (from RefSeq NM_008792.4) ENSMUST00000028905.1 ENSMUST00000028905.2 ENSMUST00000028905.3 ENSMUST00000028905.4 ENSMUST00000028905.5 ENSMUST00000028905.6 ENSMUST00000028905.7 ENSMUST00000028905.8 ENSMUST00000028905.9 NM_008792 Pcsk2 Q547J8 Q547J8_MOUSE uc008mqf.1 uc008mqf.2 uc008mqf.3 uc008mqf.4 uc008mqf.5 Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. Reaction=Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.; EC=3.4.21.94; Evidence=; Cytoplasmic vesicle, secretory vesicle Belongs to the peptidase S8 family. serine-type endopeptidase activity extracellular space nucleus proteolysis peptidase activity serine-type peptidase activity membrane peptide hormone processing hydrolase activity insulin processing secretory granule dendrite islet amyloid polypeptide processing neuronal cell body perikaryon intracellular membrane-bounded organelle macromolecular complex binding uc008mqf.1 uc008mqf.2 uc008mqf.3 uc008mqf.4 uc008mqf.5 
ENSMUST00000028907.14 Bfsp1 ENSMUST00000028907.14 beaded filament structural protein 1, in lens-CP94, transcript variant 2 (from RefSeq NM_009751.3) A2AMT1 BFSP1_MOUSE ENSMUST00000028907.1 ENSMUST00000028907.10 ENSMUST00000028907.11 ENSMUST00000028907.12 ENSMUST00000028907.13 ENSMUST00000028907.2 ENSMUST00000028907.3 ENSMUST00000028907.4 ENSMUST00000028907.5 ENSMUST00000028907.6 ENSMUST00000028907.7 ENSMUST00000028907.8 ENSMUST00000028907.9 NM_009751 O54770 Q3UPV0 Q6PFF8 Q8BKB1 Q9QWM4 uc008mqh.1 uc008mqh.2 Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (PubMed:27559293). Involved in altering the calcium regulation of MIP water permeability (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA (By similarity). Identified in a complex that contains VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (PubMed:21745462). Found in a complex composed of PPL (via C-terminal linker domain), BFSP1 and BFSP2 in the retinal lens (PubMed:19029034). Within the complex interacts with BFSP2 (PubMed:19029034). Interacts (via C-terminus) with MIP (via C-terminus) in aged lens fiber cells (By similarity). Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm Cytoplasm, cytoskeleton Cytoplasm, cell cortex Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AMT1-1; Sequence=Displayed; Name=2; IsoId=A2AMT1-2; Sequence=VSP_024920; Detected in eye lens fiber cells (at protein level) (PubMed:14985306, PubMed:19029034, PubMed:21745462). Expressed in retinal lens epithelial cells (at protein level) (PubMed:27559293). First expressed in retinal lens fiber cells during elongation and differentiation, becoming localized to the cytoplasm as fiber cells mature and the beaded filament network forms at 3 weeks of age. Proteolytically cleaved during lens cell fiber differentiation with increased fragmentation as fiber cell age increases. [Filensin C-terminal fragment]: Myristoylated at Gly-432 following proteolytic cleavage at Asp-431. [Filensin N-terminal fragment]: Acetylated at Ala-35 following proteolytic cleavage at Leu-34. Complete loss of beaded filament structures in lens epithelial cells. Belongs to the intermediate filament family. structural constituent of eye lens protein binding cytoplasm cytoskeleton intermediate filament plasma membrane cell cortex membrane cell maturation lens fiber cell development uc008mqh.1 uc008mqh.2 
ENSMUST00000028910.9 Mgme1 ENSMUST00000028910.9 mitochondrial genome maintenance exonuclease 1, transcript variant 2 (from RefSeq NM_028984.5) A2ANA5 ENSMUST00000028910.1 ENSMUST00000028910.2 ENSMUST00000028910.3 ENSMUST00000028910.4 ENSMUST00000028910.5 ENSMUST00000028910.6 ENSMUST00000028910.7 ENSMUST00000028910.8 MGME1_MOUSE NM_028984 Q3TIC0 Q543Z8 Q9CXC3 uc008mqt.1 uc008mqt.2 uc008mqt.3 uc008mqt.4 Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair (By similarity). Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. Mitochondrion Belongs to the MGME1 family. mitochondrial genome maintenance nuclease activity exonuclease activity mitochondrion mitochondrial DNA replication DNA repair cellular response to DNA damage stimulus single-stranded DNA exodeoxyribonuclease activity hydrolase activity mitochondrial DNA repair nucleic acid phosphodiester bond hydrolysis uc008mqt.1 uc008mqt.2 uc008mqt.3 uc008mqt.4 
ENSMUST00000028911.15 Kat14 ENSMUST00000028911.15 lysine acetyltransferase 14, transcript variant 1 (from RefSeq NM_181417.3) A2ANA8 CSR2B_MOUSE Csrp2bp ENSMUST00000028911.1 ENSMUST00000028911.10 ENSMUST00000028911.11 ENSMUST00000028911.12 ENSMUST00000028911.13 ENSMUST00000028911.14 ENSMUST00000028911.2 ENSMUST00000028911.3 ENSMUST00000028911.4 ENSMUST00000028911.5 ENSMUST00000028911.6 ENSMUST00000028911.7 ENSMUST00000028911.8 ENSMUST00000028911.9 Kat14 NM_181417 Q8CID0 uc008mqy.1 uc008mqy.2 uc008mqy.3 uc008mqy.4 Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle (By similarity). Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5. Nucleus Cytoplasm Note=Mainly nuclear. Early embryonic lethality. Severe growth retardation, increased apoptosis, and alterations in the cell cycle. G2/M transition of mitotic cell cycle histone acetyltransferase activity protein binding nucleus Ada2/Gcn5/Ada3 transcription activator complex cytoplasm N-acetyltransferase activity histone acetylation histone H3 acetylation uc008mqy.1 uc008mqy.2 uc008mqy.3 uc008mqy.4 
ENSMUST00000028914.9 Polr3f ENSMUST00000028914.9 polymerase (RNA) III (DNA directed) polypeptide F (from RefSeq NM_029763.3) ENSMUST00000028914.1 ENSMUST00000028914.2 ENSMUST00000028914.3 ENSMUST00000028914.4 ENSMUST00000028914.5 ENSMUST00000028914.6 ENSMUST00000028914.7 ENSMUST00000028914.8 NM_029763 Polr3f Q544K6 Q921X6 RPC6_MOUSE uc008mrg.1 uc008mrg.2 uc008mrg.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer that coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, including varicella zoster virus. Acts as a nuclear and cytosolic DNA sensor detecting AT-rich DNA, involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (By similarity). Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3- POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination (By similarity). Directly interacts with POLR3C (By similarity). Interacts with TBP and TFIIIB90 and GTF3C4 (By similarity). Interacts with MAF1. As part of the RNA polymerase III complex, interacts with PKP2 (By similarity). Nucleus The [4FE-4S] cluster-binding domain adopts a globular structure that serves as an interaction hub that connects the POLR3C/RPC3- POLR3F/RPC6-POLR3G/RPC7 heterotrimer to the Pol III core. Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. immune system process double-stranded DNA binding DNA-directed 5'-3' RNA polymerase activity nucleus DNA-directed RNA polymerase III complex transcription from RNA polymerase III promoter positive regulation of interferon-beta production innate immune response positive regulation of innate immune response defense response to virus RNA polymerase III activity uc008mrg.1 uc008mrg.2 uc008mrg.3 
ENSMUST00000028915.6 Rbbp9 ENSMUST00000028915.6 retinoblastoma binding protein 9, serine hydrolase (from RefSeq NM_015754.2) Bog ENSMUST00000028915.1 ENSMUST00000028915.2 ENSMUST00000028915.3 ENSMUST00000028915.4 ENSMUST00000028915.5 NM_015754 O88851 Q9CYJ9 RBBP9_MOUSE uc008mri.1 uc008mri.2 uc008mri.3 Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. Interacts with RB1; the interaction disrupts RB1 binding to E2F1. Interacts with RBL1 and RBL2. Expressed in spleen. Following chronic low dose of ionizing radiation, expression is up-regulated in male spleen and down-regulated in female spleen (at protein level). Belongs to the RBBP9 family. Sequence=AAC63497.1; Type=Frameshift; Evidence=; Sequence=AK017606; Type=Frameshift; Evidence=; molecular_function nucleus nucleoplasm cytoplasm hydrolase activity regulation of cell proliferation uc008mri.1 uc008mri.2 uc008mri.3 
ENSMUST00000028916.15 Sec23b ENSMUST00000028916.15 SEC23 homolog B, COPII coat complex component, transcript variant 14 (from RefSeq NR_178208.1) A2ANA1 ENSMUST00000028916.1 ENSMUST00000028916.10 ENSMUST00000028916.11 ENSMUST00000028916.12 ENSMUST00000028916.13 ENSMUST00000028916.14 ENSMUST00000028916.2 ENSMUST00000028916.3 ENSMUST00000028916.4 ENSMUST00000028916.5 ENSMUST00000028916.6 ENSMUST00000028916.7 ENSMUST00000028916.8 ENSMUST00000028916.9 NR_178208 Q3U6B3 Q99K49 Q9D662 Q9QZ68 SC23B_MOUSE Sec23b uc008mrl.1 uc008mrl.2 uc008mrl.3 uc008mrl.4 Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (By similarity). Interacts with SAR1A (By similarity). Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytosol Belongs to the SEC23/SEC24 family. SEC23 subfamily. Golgi membrane GTPase activator activity protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol intracellular protein transport ER to Golgi vesicle-mediated transport zinc ion binding endomembrane system ER to Golgi transport vesicle membrane protein transport membrane vesicle-mediated transport COPII vesicle coat cytoplasmic vesicle positive regulation of GTPase activity metal ion binding perinuclear region of cytoplasm endoplasmic reticulum exit site cargo loading into COPII-coated vesicle COPII-coated vesicle budding uc008mrl.1 uc008mrl.2 uc008mrl.3 uc008mrl.4 
ENSMUST00000028917.7 Dtd1 ENSMUST00000028917.7 D-tyrosyl-tRNA deacylase 1 (from RefSeq NM_025314.3) A2ANA2 DTD1_MOUSE ENSMUST00000028917.1 ENSMUST00000028917.2 ENSMUST00000028917.3 ENSMUST00000028917.4 ENSMUST00000028917.5 ENSMUST00000028917.6 Hars2 NM_025314 Q3TY44 Q9CRE8 Q9CYL0 Q9D013 Q9D1G4 Q9DD18 uc008mro.1 uc008mro.2 uc008mro.3 uc008mro.4 An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. Reaction=glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala); Xref=Rhea:RHEA:53744, Rhea:RHEA-COMP:9657, Rhea:RHEA-COMP:13640, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305, ChEBI:CHEBI:78442, ChEBI:CHEBI:78522; EC=3.1.1.96; Evidence=; Reaction=a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+); Xref=Rhea:RHEA:13953, Rhea:RHEA-COMP:10123, Rhea:RHEA- COMP:10124, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:59871, ChEBI:CHEBI:78442, ChEBI:CHEBI:79333; EC=3.1.1.96; Evidence=; Homodimer. Interacts with CDC45 and TOPBP1 (By similarity). Nucleus Cytoplasm Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DD18-1; Sequence=Displayed; Name=2; IsoId=Q9DD18-2; Sequence=VSP_026130; A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids. Preferentially phosphorylated in cells arrested early in S phase. Phosphorylation in the C-terminus weakens the interaction with CDC45 (By similarity). Belongs to the DTD family. Sequence=BAB30808.1; Type=Frameshift; Evidence=; tRNA binding aminoacyl-tRNA editing activity DNA binding RNA binding nucleus nucleolus cytoplasm cytosol DNA replication tRNA metabolic process hydrolase activity metal ion binding D-aminoacyl-tRNA deacylase activity D-tyrosyl-tRNA(Tyr) deacylase activity uc008mro.1 uc008mro.2 uc008mro.3 uc008mro.4 
ENSMUST00000028918.4 Scp2d1 ENSMUST00000028918.4 SCP2 sterol-binding domain containing 1 (from RefSeq NM_025490.2) ENSMUST00000028918.1 ENSMUST00000028918.2 ENSMUST00000028918.3 NM_025490 Q5RL24 Q9DAH1 SCP2D_MOUSE uc008mrp.1 uc008mrp.2 uc008mrp.3 Sequence=BAB24272.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cellular_component steroid biosynthetic process phospholipid transport positive regulation of intracellular cholesterol transport uc008mrp.1 uc008mrp.2 uc008mrp.3 
ENSMUST00000028921.6 Xrn2 ENSMUST00000028921.6 5'-3' exoribonuclease 2, transcript variant 1 (from RefSeq NM_011917.3) Dhm1 ENSMUST00000028921.1 ENSMUST00000028921.2 ENSMUST00000028921.3 ENSMUST00000028921.4 ENSMUST00000028921.5 NM_011917 Q3TI26 Q3TKF2 Q3UZT9 Q61489 Q99KS7 Q9DBR1 XRN2_MOUSE uc008msr.1 uc008msr.2 uc008msr.3 uc008msr.4 Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (By similarity). Interacts with POLR2A and SMN1/SMN2. Interacts with CDKN2AIP and NKRF. Interacts with CDKN2AIPNL; the interaction is direct. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (By similarity). Interacts with DHX34; the interaction is RNA-independent (By similarity). Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DBR1-1; Sequence=Displayed; Name=2; IsoId=Q9DBR1-2; Sequence=VSP_007235; Expressed in the spleen, testis, heart, brain, lung, liver, skeletal muscle, and kidney. [Isoform 2]: May result from the retention of an intron in the cDNA. Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. Sequence=AAH04028.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; 3'-5'-exoribonuclease activity DNA catabolic process, exonucleolytic transcription termination site sequence-specific DNA binding nucleic acid binding DNA binding nuclease activity exonuclease activity 5'-3' exoribonuclease activity protein binding nucleus nucleolus nucleobase-containing compound metabolic process DNA repair DNA recombination DNA-templated transcription, termination mRNA processing microtubule-based process spermatogenesis 5'-3' exonuclease activity RNA metabolic process aggresome hydrolase activity hippocampus development neuron differentiation metal ion binding retina development in camera-type eye RNA phosphodiester bond hydrolysis, exonucleolytic uc008msr.1 uc008msr.2 uc008msr.3 uc008msr.4 
ENSMUST00000028926.13 Napb ENSMUST00000028926.13 N-ethylmaleimide sensitive fusion protein attachment protein beta, transcript variant 3 (from RefSeq NR_185172.1) ENSMUST00000028926.1 ENSMUST00000028926.10 ENSMUST00000028926.11 ENSMUST00000028926.12 ENSMUST00000028926.2 ENSMUST00000028926.3 ENSMUST00000028926.4 ENSMUST00000028926.5 ENSMUST00000028926.6 ENSMUST00000028926.7 ENSMUST00000028926.8 ENSMUST00000028926.9 NR_185172 P28663 SNAB_MOUSE Snapb uc008mti.1 uc008mti.2 uc008mti.3 Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. Membrane; Peripheral membrane protein. Cerebral cortex, cerebellar cortex, hippocampus, and dentate gyrus, weakly expressed in the putamen, the thalamus and the brain stem. Belongs to the SNAP family. SNARE binding regulation of receptor internalization soluble NSF attachment protein activity protein binding vacuolar membrane intracellular protein transport regulation of synaptic vesicle priming protein transport membrane vesicle-mediated transport syntaxin binding SNARE complex macromolecular complex disassembly synaptic transmission, glutamatergic SNARE complex disassembly myelin sheath regulation of ATPase activity synaptic vesicle endocytosis synaptobrevin 2-SNAP-25-syntaxin-1a complex presynapse postsynapse glutamatergic synapse uc008mti.1 uc008mti.2 uc008mti.3 
ENSMUST00000028928.8 Gzf1 ENSMUST00000028928.8 GDNF-inducible zinc finger protein 1, transcript variant 2 (from RefSeq NM_028986.3) ENSMUST00000028928.1 ENSMUST00000028928.2 ENSMUST00000028928.3 ENSMUST00000028928.4 ENSMUST00000028928.5 ENSMUST00000028928.6 ENSMUST00000028928.7 GZF1_MOUSE Gzf1 NM_028986 Q4VBD9 Q8BGY0 Zfp336 uc008mtg.1 uc008mtg.2 uc008mtg.3 uc008mtg.4 Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. Interacts with NCL. Nucleus toplasm cleus, nucleolus Note=Predominantly nuclear. Expressed in several tissues, with highest levels in liver. Also expressed in embryos from 7 to 17 dpc. At 13.5-14.5 dpc, strong expression in ureteric buds (at protein level). Expression decreases in the kidney after birth (at protein level). Expressed in the eyes and limbs during development (at protein level). Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding branching involved in ureteric bud morphogenesis nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleolus cytoplasm sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding uc008mtg.1 uc008mtg.2 uc008mtg.3 uc008mtg.4 
ENSMUST00000028931.10 Cst8 ENSMUST00000028931.10 cystatin 8 (cystatin-related epididymal spermatogenic) (from RefSeq NM_009978.2) CST8_MOUSE Cres ENSMUST00000028931.1 ENSMUST00000028931.2 ENSMUST00000028931.3 ENSMUST00000028931.4 ENSMUST00000028931.5 ENSMUST00000028931.6 ENSMUST00000028931.7 ENSMUST00000028931.8 ENSMUST00000028931.9 NM_009978 O89102 P32766 Q543A7 uc008mto.1 uc008mto.2 uc008mto.3 Performs a specialized role during sperm development and maturation. Secreted. Proximal caput region of the epididymis. Lower expression in the testis. Within the testis it is localized to the elongating spermatids, whereas within the epididymis it is exclusively synthesized by the proximal caput epithelium. Testicular factors or hormones other than androgens present in the testicular fluid may be involved in the regulation of CRES gene expression. Belongs to the cystatin family. cysteine-type endopeptidase inhibitor activity extracellular region cytoplasm cell surface negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc008mto.1 uc008mto.2 uc008mto.3 
ENSMUST00000028932.4 Cst12 ENSMUST00000028932.4 cystatin 12 (from RefSeq NM_027054.2) CST12_MOUSE ENSMUST00000028932.1 ENSMUST00000028932.2 ENSMUST00000028932.3 NM_027054 Q9DAN8 uc290bec.1 uc290bec.2 May play a specialized role in spermatogenesis. Secreted Located at the very proximal caput epididymis (at protein level). Expressed in epididymis, Sertoli cells and testis. Also found to be weakly expressed in ovary and prostate. Belongs to the cystatin family. cysteine-type endopeptidase inhibitor activity extracellular region negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc290bec.1 uc290bec.2 
ENSMUST00000028933.3 Cstdc1 ENSMUST00000028933.3 cystatin domain containing 1 (from RefSeq NM_030135.3) CST14_MOUSE Cst14 ENSMUST00000028933.1 ENSMUST00000028933.2 NM_030135 Q8VII3 Q9CX46 uc008mtm.1 uc008mtm.2 uc008mtm.3 May play a specialized role in spermatogenesis. Secreted Located only in seminiferous tubules (at protein level). Expressed in testis and Sertoli cells. Belongs to the cystatin family. cysteine-type endopeptidase inhibitor activity extracellular region negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc008mtm.1 uc008mtm.2 uc008mtm.3 
ENSMUST00000028934.3 Cst11 ENSMUST00000028934.3 cystatin 11 (from RefSeq NM_030059.2) CST11_MOUSE CSTE1 Cres2 Cst11 ENSMUST00000028934.1 ENSMUST00000028934.2 NM_030059 Q7M731 Q9D269 uc008mtl.1 uc008mtl.2 uc008mtl.3 Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Secreted Note=Probably secreted into the epididymis lumen, where it localizes to the outer surface of sperm. Specifically localizes to the postacrosomal and tail regions of sperm. Expressed in epididymis, where it localizes to the proximal caput and also part of the midcaput. Not detected in other tissues tested. Up-regulated by testicular factors. However, does not seem to be directly regulated by androgens or estrogen. Belongs to the cystatin family. cysteine-type endopeptidase inhibitor activity extracellular region nucleus cytoplasm negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity androgen receptor signaling pathway killing of cells of other organism sperm flagellum defense response to Gram-negative bacterium uc008mtl.1 uc008mtl.2 uc008mtl.3 
ENSMUST00000028935.4 Cst9 ENSMUST00000028935.4 cystatin 9 (from RefSeq NM_009979.1) CST9_MOUSE Cresp ENSMUST00000028935.1 ENSMUST00000028935.2 ENSMUST00000028935.3 NM_009979 Q545L7 Q9Z0H6 uc008mtr.1 uc008mtr.2 uc008mtr.3 May be involved in testis development (PubMed:9826679). May play a role in hematopoietic differentiation or inflammation (By similarity). Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria (PubMed:23922243). Secreted Expression is restricted to fetal gonads and adult testis. Expressed during testis cord formation in pre- Sertoli cells, at a time immediately after the peak of SRY expression. No visible phenotype; probably due to redundancy with other family members. Belongs to the cystatin family. cysteine-type endopeptidase inhibitor activity extracellular region negative regulation of peptidase activity negative regulation of endopeptidase activity antimicrobial humoral response peptidase inhibitor activity uc008mtr.1 uc008mtr.2 uc008mtr.3 
ENSMUST00000028937.3 Cstdc2 ENSMUST00000028937.3 cystatin domain containing 2 (from RefSeq NM_029960.3) 9230104L09Rik Cstdc2 ENSMUST00000028937.1 ENSMUST00000028937.2 NM_029960 Q9D264 Q9D264_MOUSE uc008mts.1 uc008mts.2 uc008mts.3 uc008mts.4 Secreted Belongs to the cystatin family. cysteine-type endopeptidase inhibitor activity negative regulation of endopeptidase activity uc008mts.1 uc008mts.2 uc008mts.3 uc008mts.4 
ENSMUST00000028938.7 Cst3 ENSMUST00000028938.7 cystatin C (from RefSeq NM_009976.4) CYTC_MOUSE ENSMUST00000028938.1 ENSMUST00000028938.2 ENSMUST00000028938.3 ENSMUST00000028938.4 ENSMUST00000028938.5 ENSMUST00000028938.6 NM_009976 P21460 Q544Y0 uc008mtt.1 uc008mtt.2 uc008mtt.3 uc008mtt.4 The protein encoded by this gene is a cysteine protease inhibitor involved in neurodegenerative and cardiovascular processes. The encoded protein inhibits aggregation of beta-amyloid protein, a hallmark of Alzheimer's disease, so it may be useful as a therapeutic. This protein also may be a biomarker for atherosclerosis. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA457140.1, CB205647.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Secreted Belongs to the cystatin family. beta-amyloid binding eye development response to hypoxia cell activation protease binding endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular region basement membrane extracellular space cytoplasm lysosome multivesicular body endoplasmic reticulum Golgi apparatus plasma membrane apoptotic process defense response response to oxidative stress brain development salivary gland development embryo implantation positive regulation of cell proliferation male gonad development response to toxic substance response to carbohydrate response to inorganic substance negative regulation of peptidase activity negative regulation of endopeptidase activity response to organic cyclic compound peptidase inhibitor activity axon response to nutrient levels nuclear membrane vesicle response to estradiol cellular response to oxidative stress response to drug circadian sleep/wake cycle, REM sleep identical protein binding cell projection neuronal cell body regulation of programmed cell death contractile fiber positive regulation of DNA replication negative regulation of proteolysis perinuclear region of cytoplasm response to axon injury Sertoli cell development negative regulation of elastin catabolic process negative regulation of cell death cellular response to hydrogen peroxide supramolecular fiber organization uc008mtt.1 uc008mtt.2 uc008mtt.3 uc008mtt.4 
ENSMUST00000028944.4 Acss1 ENSMUST00000028944.4 acyl-CoA synthetase short-chain family member 1 (from RefSeq NM_080575.2) ACS2L_MOUSE Acas2 Acas2l ENSMUST00000028944.1 ENSMUST00000028944.2 ENSMUST00000028944.3 NM_080575 Q8K0M6 Q99NB1 uc008muf.1 uc008muf.2 uc008muf.3 uc008muf.4 Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:11150295, PubMed:16790548). Acetate is the preferred substrate (PubMed:11150295, PubMed:16790548). Can also utilize propionate with a much lower affinity (PubMed:11150295). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (PubMed:11150295). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (PubMed:19187775). Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:456215; EC=6.2.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23177; Evidence=; Reaction=ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA; Xref=Rhea:RHEA:20373, ChEBI:CHEBI:17272, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392, ChEBI:CHEBI:456215; EC=6.2.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20374; Evidence=; Inhibited by acetylation at Lys-635 and activated by deacetylation mediated by the deacetylase SIRT3. Kinetic parameters: KM=0.06 mM for acetate ; KM=4.1 mM for propionate ; Interacts with SIRT3. Mitochondrion matrix Highly expressed in heart, testis, kidney, skeletal muscle, lung and spleen. Detected at low levels in brain. By fasting. Reversibly acetylated at Lys-635 (PubMed:16790548). The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylase SIRT3. No visible phenotype at birth, but exhibit significant growth retardation at the time of weaning. Attain normal size and weight when fed normally. Exhibit hypothermia and hypoglycemia when fed high-fat, low-carbohydrate diet, leading to 50% mortality. Display strongly reduced whole-body acetate oxidation when fasting. Fasting adults exhibit hypothermia, reduced capacity to sustain running and low ATP levels. Belongs to the ATP-dependent AMP-binding enzyme family. Sequence=AAH30930.1; Type=Erroneous initiation; Evidence=; nucleotide binding catalytic activity acetate-CoA ligase activity ATP binding mitochondrion mitochondrial matrix acetyl-CoA biosynthetic process AMP binding ligase activity acetate biosynthetic process acetyl-CoA biosynthetic process from acetate propionate biosynthetic process propionate-CoA ligase activity uc008muf.1 uc008muf.2 uc008muf.3 uc008muf.4 
ENSMUST00000028948.5 Gins1 ENSMUST00000028948.5 GINS complex subunit 1, transcript variant 1 (from RefSeq NM_027014.1) ENSMUST00000028948.1 ENSMUST00000028948.2 ENSMUST00000028948.3 ENSMUST00000028948.4 NM_027014 PSF1_MOUSE Psf1 Q9CZ15 uc008mus.1 uc008mus.2 uc008mus.3 Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex. Nucleus Chromosome Note=Associates with chromatin. Belongs to the GINS1/PSF1 family. GINS complex inner cell mass cell proliferation protein binding nucleus cytoplasm DNA replication DNA duplex unwinding 3'-5' DNA helicase activity DNA strand elongation involved in mitotic DNA replication uc008mus.1 uc008mus.2 uc008mus.3 
ENSMUST00000028949.16 Nsfl1c ENSMUST00000028949.16 NSFL1 (p97) cofactor (p47), transcript variant 2 (from RefSeq NM_001291074.1) A2AT03 ENSMUST00000028949.1 ENSMUST00000028949.10 ENSMUST00000028949.11 ENSMUST00000028949.12 ENSMUST00000028949.13 ENSMUST00000028949.14 ENSMUST00000028949.15 ENSMUST00000028949.2 ENSMUST00000028949.3 ENSMUST00000028949.4 ENSMUST00000028949.5 ENSMUST00000028949.6 ENSMUST00000028949.7 ENSMUST00000028949.8 ENSMUST00000028949.9 NM_001291074 NSF1C_MOUSE Q80Y15 Q8BYL3 Q9CZ44 uc033hqq.1 uc033hqq.2 uc033hqq.3 uc033hqq.4 Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine- containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA- like domain when bound to VCP (By similarity). Nucleus Golgi apparatus, Golgi stack Chromosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9CZ44-1; Sequence=Displayed; Name=2; IsoId=Q9CZ44-2; Sequence=VSP_009264, VSP_009265, VSP_009266; Name=3; IsoId=Q9CZ44-3; Sequence=VSP_009264; Phosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the fragmentation of the Golgi stacks during mitosis (By similarity). Belongs to the NSFL1C family. autophagosome assembly establishment of mitotic spindle orientation protein binding phospholipid binding nucleus nucleoplasm chromosome cytoplasm Golgi apparatus Golgi stack microtubule organizing center cytosol cytoskeleton plasma membrane Golgi organization lipid binding nuclear envelope reassembly spindle pole centrosome ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process intermediate filament cytoskeleton positive regulation of mitotic centrosome separation ATPase binding membrane fusion negative regulation of protein localization to centrosome VCP-NSFL1C complex uc033hqq.1 uc033hqq.2 uc033hqq.3 uc033hqq.4 
ENSMUST00000028950.9 Sdcbp2 ENSMUST00000028950.9 syndecan binding protein (syntenin) 2 (from RefSeq NM_145535.2) ENSMUST00000028950.1 ENSMUST00000028950.2 ENSMUST00000028950.3 ENSMUST00000028950.4 ENSMUST00000028950.5 ENSMUST00000028950.6 ENSMUST00000028950.7 ENSMUST00000028950.8 NM_145535 Q3UN51 Q99JZ0 SDCB2_MOUSE uc008nec.1 uc008nec.2 uc008nec.3 uc008nec.4 Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival. Monomer and homodimer. Interacts with SDCBP. Interacts with TM4SF1. Cytoplasm Nucleus, nucleolus Nucleus, nucleoplasm Cell membrane Nucleus speckle Note=Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments. Colocalizes with TM4SF1 in the apical region of the cell. Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments. PIP2 plays an important role in the distribution of SDCBP2. The two PDZ domains mediate the interaction with phosphatidylinositol 4,5-bisphosphate (PIP2) and target SDCBP2 to the plasma membranes and nucleoli, PIP2-rich regions. phosphatidylinositol-4,5-bisphosphate binding nucleus nucleoplasm nucleolus cytoplasm plasma membrane protein C-terminus binding cell proliferation lipid binding membrane nuclear speck identical protein binding protein homodimerization activity protein heterodimerization activity uc008nec.1 uc008nec.2 uc008nec.3 uc008nec.4 
ENSMUST00000028951.14 Snph ENSMUST00000028951.14 syntaphilin, transcript variant 1 (from RefSeq NM_198214.3) A2AT08 A2AT09 A2AT10 A2AT11 A4FUV3 A4VCI7 ENSMUST00000028951.1 ENSMUST00000028951.10 ENSMUST00000028951.11 ENSMUST00000028951.12 ENSMUST00000028951.13 ENSMUST00000028951.2 ENSMUST00000028951.3 ENSMUST00000028951.4 ENSMUST00000028951.5 ENSMUST00000028951.6 ENSMUST00000028951.7 ENSMUST00000028951.8 ENSMUST00000028951.9 Kiaa0374 NM_198214 Q4VA51 Q6GQX4 Q80U23 Q8C8B8 SNPH_MOUSE Snph uc008ned.1 uc008ned.2 uc008ned.3 uc008ned.4 Inhibits SNARE complex formation by absorbing free STX1A. Binds to STX1A (By similarity). Interacts with DNM1; this interaction inhibits the binding of DNM1 to AMPH and DNM1-receptor- mediated endocytosis (By similarity). Membrane ; Single-pass membrane protein Synapse, synaptosome. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80U23-1; Sequence=Displayed; Name=2; IsoId=Q80U23-2; Sequence=VSP_037439; Name=3; IsoId=Q80U23-3; Sequence=VSP_037440; Sequence=AAH72567.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH96541.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAI39793.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC33090.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC65544.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cytoplasm mitochondrion cytoplasmic microtubule plasma membrane vesicle fusion brain development membrane integral component of membrane syntaxin-1 binding cell junction neuron differentiation mitochondrial membrane presynaptic membrane neuron projection neuronal cell body synapse negative regulation of endocytosis uc008ned.1 uc008ned.2 uc008ned.3 uc008ned.4 
ENSMUST00000028955.6 Angpt4 ENSMUST00000028955.6 angiopoietin 4 (from RefSeq NM_009641.2) ANGP4_MOUSE Agpt4 Ang3 ENSMUST00000028955.1 ENSMUST00000028955.2 ENSMUST00000028955.3 ENSMUST00000028955.4 ENSMUST00000028955.5 NM_009641 Q9WVH6 uc008neq.1 uc008neq.2 uc008neq.3 This gene is a member of the angiopoietin family of secreted growth factors comprising Angiopoietins-1, -2, and -3, all of which bind the TEK Receptor Tyrosine Kinase. Angiopoietin/TEK Receptor Tyrosine Kinase signaling is involved in survival and migration of endothelial cells and regulates vascular remodeling and maintenance of vascular integrity. Angiopoietin/TEK Receptor Tyrosine Kinase signaling is also required for lymphangiogenesis. Family members bind TEK Receptor Tyrosine Kinase as multimeric clusters but their oligomerization properties differ from one another and this is thought to provide a mechanistic basis for their distinct physiologic roles. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK132988.1, BC129965.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. Homodimer; disulfide-linked. Interacts with TEK/TIE2. Secreted Widely expressed. angiogenesis vascular endothelial growth factor receptor binding extracellular region extracellular space activation of transmembrane receptor protein tyrosine kinase activity Notch signaling pathway endoderm development positive regulation of endothelial cell migration negative regulation of angiogenesis transmembrane receptor protein tyrosine kinase activator activity receptor tyrosine kinase binding negative regulation of apoptotic process positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration positive regulation of angiogenesis Tie signaling pathway positive regulation of peptidyl-tyrosine phosphorylation cellular response to hypoxia uc008neq.1 uc008neq.2 uc008neq.3 
ENSMUST00000028963.14 Tbc1d20 ENSMUST00000028963.14 TBC1 domain family, member 20, transcript variant 2 (from RefSeq NR_156111.1) ENSMUST00000028963.1 ENSMUST00000028963.10 ENSMUST00000028963.11 ENSMUST00000028963.12 ENSMUST00000028963.13 ENSMUST00000028963.2 ENSMUST00000028963.3 ENSMUST00000028963.4 ENSMUST00000028963.5 ENSMUST00000028963.6 ENSMUST00000028963.7 ENSMUST00000028963.8 ENSMUST00000028963.9 NR_156111 Q3TYW9 Q99LW2 Q9D9I4 TBC20_MOUSE uc008nfb.1 uc008nfb.2 uc008nfb.3 GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude (By similarity). Involved in maintaining endoplasmic reticulum structure (By similarity). Membrane ; Multi-pass membrane protein The arginine and glutamine fingers are critical for the GTPase- activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site. Note=Defects in Tbc1d20 are the cause of spontaneous autosomal recessive blind sterile (bs) phenotype. Bs animals exhibit embryonic non-progressive nuclear cataracts and spermatid abnormalities associated with male infertility. acrosome assembly lens development in camera-type eye GTPase activator activity endoplasmic reticulum endoplasmic reticulum membrane ER to Golgi vesicle-mediated transport Golgi organization spermatogenesis male gonad development membrane integral component of membrane Rab GTPase binding virion assembly integral component of Golgi membrane nuclear membrane lipid particle organization camera-type eye development positive regulation of GTPase activity positive regulation by host of viral genome replication positive regulation by virus of viral protein levels in host cell lens fiber cell morphogenesis seminiferous tubule development cargo loading into COPII-coated vesicle positive regulation of ER to Golgi vesicle-mediated transport uc008nfb.1 uc008nfb.2 uc008nfb.3 
ENSMUST00000028964.14 Rbck1 ENSMUST00000028964.14 RanBP-type and C3HC4-type zinc finger containing 1, transcript variant 19 (from RefSeq NR_185284.1) A2ANR4 ENSMUST00000028964.1 ENSMUST00000028964.10 ENSMUST00000028964.11 ENSMUST00000028964.12 ENSMUST00000028964.13 ENSMUST00000028964.2 ENSMUST00000028964.3 ENSMUST00000028964.4 ENSMUST00000028964.5 ENSMUST00000028964.6 ENSMUST00000028964.7 ENSMUST00000028964.8 ENSMUST00000028964.9 HOIL1_MOUSE NR_185284 Q3TM86 Q8C2I0 Q9WUB0 Rbck Ubce7ip3 Uip28 uc008nfe.1 uc008nfe.2 uc008nfe.3 E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin. The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types. Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence=; Protein modification; protein ubiquitination. Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31. LUBAC has a MW of approximately 600 kDa suggesting a heteromultimeric assembly of its subunits (By similarity). Interacts with beta-I-type (PRKCB1) and zeta-type protein kinase C (PRKCZ) (By similarity). Interacts with UBE2L3 (PubMed:10431818). Interacts with IREB2 only in iron-rich conditions. Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner. Interacts with EYA1, TAB2, TAB3, MAP3K7 TRAF6 and RIPK1 (PubMed:20956555). Interacts with IRF3 (By similarity). Q9WUB0; P97767: Eya1; NbExp=2; IntAct=EBI-6141072, EBI-1368503; Q9WUB0; Q924T7: Rnf31; NbExp=10; IntAct=EBI-6141072, EBI-647680; The RanBP2-type zinc finger, also called Npl4 zinc finger (NZF), mediates binding to 'Met-1'-linked polyubiquitins. The UBL domain mediates association with RNF31 via interaction with its UBA domain. Auto-ubiquitinated. Auto-ubiquitination leads to degradation by the proteasome (By similarity). Phosphorylated. In vitro, phosphorylation inhibits auto- ubiquitination activity (By similarity). Impaired TNF-alpha-mediated NF-kappa-B activation and enhanced JNK-mediated apoptosis. Belongs to the RBR family. Sequence=AAD24572.1; Type=Erroneous initiation; Evidence=; Sequence=AAH34555.1; Type=Erroneous initiation; Evidence=; protein polyubiquitination double-stranded DNA binding ubiquitin-protein transferase activity protein kinase C binding protein binding transferase activity negative regulation of NF-kappaB transcription factor activity identical protein binding positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of transcription from RNA polymerase II promoter metal ion binding T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity negative regulation of necroptotic process LUBAC complex protein linear polyubiquitination positive regulation of NIK/NF-kappaB signaling positive regulation of extrinsic apoptotic signaling pathway uc008nfe.1 uc008nfe.2 uc008nfe.3 
ENSMUST00000028966.3 Defb22 ENSMUST00000028966.3 defensin beta 22 (from RefSeq NM_001002791.2) DFB22_MOUSE Defb22 ENSMUST00000028966.1 ENSMUST00000028966.2 NM_001002791 Q8BVC1 uc008nfn.1 uc008nfn.2 uc008nfn.3 Probable component of sperm glycocalyx. Likely protects and facilitates transport of sperm in the female reproductive tract. Probably released from the sperm surface during capacitation. Cytoplasmic vesicle, secretory vesicle, acrosome Secreted, extracellular space Note=In the corpus epididymis, located in vesicles below the apical surface of the plasma membrane. Secreted by epididymal cells and absorbed to the surface of sperm during transit through the epididymis. Coats the entire surface of ejaculated sperm although presence on the equatorial segment is less intense. Specifically expressed in corpus epididymis and cauda epididymis with expression in corpus being highest (at protein level). Not detected in other tissues tested, including testis, prostate, seminal vesicle and vas deferens (at protein level). O-glycosylated; glycans contain alpha(2,3)-linked sialic acids. Belongs to the beta-defensin family. acrosomal vesicle molecular_function extracellular region extracellular space cell surface glycocalyx cytoplasmic vesicle innate immune response uc008nfn.1 uc008nfn.2 uc008nfn.3 
ENSMUST00000028970.8 Mylk2 ENSMUST00000028970.8 myosin, light polypeptide kinase 2, skeletal muscle (from RefSeq NM_001081044.2) A2APB9 ENSMUST00000028970.1 ENSMUST00000028970.2 ENSMUST00000028970.3 ENSMUST00000028970.4 ENSMUST00000028970.5 ENSMUST00000028970.6 ENSMUST00000028970.7 MYLK2_MOUSE NM_001081044 Q8VCR8 uc008ngs.1 uc008ngs.2 uc008ngs.3 uc008ngs.4 Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain (By similarity). Reaction=ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L- seryl-[myosin light chain]; Xref=Rhea:RHEA:22004, Rhea:RHEA- COMP:13684, Rhea:RHEA-COMP:13685, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.18; Reaction=ATP + L-threonyl-[myosin light chain] = ADP + H(+) + O- phospho-L-threonyl-[myosin light chain]; Xref=Rhea:RHEA:53900, Rhea:RHEA-COMP:13686, Rhea:RHEA-COMP:13687, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.18; May interact with centrin. Cytoplasm Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity myosin light chain kinase activity protein binding calmodulin binding ATP binding nucleus cytoplasm protein phosphorylation water transport regulation of muscle contraction striated muscle contraction neuromuscular synaptic transmission synaptic vesicle positive regulation of gene expression postsynaptic density skeletal muscle satellite cell differentiation kinase activity phosphorylation transferase activity peptidyl-threonine phosphorylation dendrite positive regulation of fast-twitch skeletal muscle fiber contraction myosin light chain binding regulation of muscle filament sliding skeletal muscle cell differentiation neuronal cell body terminal bouton dendritic spine regulation of MAPK cascade protein autophosphorylation regulation of neuronal synaptic plasticity synaptic vesicle transport regulation of cell cycle cardiac muscle cell differentiation cardiac muscle tissue morphogenesis uc008ngs.1 uc008ngs.2 uc008ngs.3 uc008ngs.4 
ENSMUST00000028972.9 Pdrg1 ENSMUST00000028972.9 p53 and DNA damage regulated 1, transcript variant 1 (from RefSeq NM_178939.3) ENSMUST00000028972.1 ENSMUST00000028972.2 ENSMUST00000028972.3 ENSMUST00000028972.4 ENSMUST00000028972.5 ENSMUST00000028972.6 ENSMUST00000028972.7 ENSMUST00000028972.8 NM_178939 Pdrg1 Q3UKN2 Q3UKN2_MOUSE uc008ngz.1 uc008ngz.2 uc008ngz.3 May play a role in chaperone-mediated protein folding. Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92. Cytoplasm Belongs to the prefoldin subunit beta family. protein folding prefoldin complex unfolded protein binding uc008ngz.1 uc008ngz.2 uc008ngz.3 
ENSMUST00000028977.7 Kif3b ENSMUST00000028977.7 kinesin family member 3B (from RefSeq NM_008444.4) ENSMUST00000028977.1 ENSMUST00000028977.2 ENSMUST00000028977.3 ENSMUST00000028977.4 ENSMUST00000028977.5 ENSMUST00000028977.6 KIF3B_MOUSE Kif3b NM_008444 Q3UFZ8 Q61771 Q8BNH4 uc008nhp.1 uc008nhp.2 uc008nhp.3 uc008nhp.4 uc008nhp.5 Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (PubMed:7559760). Plays a role in cilia formation (PubMed:9865700). Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (By similarity). Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites (PubMed:31746486). Heterodimer of KIF3A and KIF3B (PubMed:7559760). KIF3A/KIF3B heterodimer interacts with KIFAP3 forming a heterotrimeric (KIF3A/KIF3B/KIFAP3) complex (PubMed:8710890). Interacts with the SMC3 subunit of the cohesin complex (By similarity). Interacts directly with IFT20 (PubMed:12821668). Interacts with FLCN (By similarity). Q61771; P28741: Kif3a; NbExp=6; IntAct=EBI-6395332, EBI-6169413; Q61771; Q8VI40: Trim60; NbExp=3; IntAct=EBI-6395332, EBI-6395249; Cytoplasm, cytoskeleton Cell projection, cilium ll projection, dendritic spine Note=Colocalized with GRIN2A in dendritic shafts and in DLG4-positive spines. Deficient mice do not survive beyond midgestation, exhibiting growth retardation, pericardial sac ballooning, and neural tube disorganization (PubMed:9865700). Kif3b +/- mice exhibit schizophrenia-like phenotypes, both behaviorally and histologically. Hippocampal neurons have altered spine morphology and synapse function, and at the cellular level, they display abnormal growth cone morphology (PubMed:31746486). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. nucleotide binding microtubule motor activity protein binding ATP binding cytoplasm centrosome spindle cytosol cytoskeleton kinesin complex microtubule cilium microtubule-based movement microtubule binding microtubule cytoskeleton ATPase activity kinesin II complex Rho GTPase binding axon midbody positive regulation of cytokinesis cell projection mitotic spindle assembly uc008nhp.1 uc008nhp.2 uc008nhp.3 uc008nhp.4 uc008nhp.5 
ENSMUST00000028981.9 Mapre1 ENSMUST00000028981.9 microtubule-associated protein, RP/EB family, member 1 (from RefSeq NM_007896.3) ENSMUST00000028981.1 ENSMUST00000028981.2 ENSMUST00000028981.3 ENSMUST00000028981.4 ENSMUST00000028981.5 ENSMUST00000028981.6 ENSMUST00000028981.7 ENSMUST00000028981.8 MARE1_MOUSE NM_007896 Q61166 Q7TN34 uc008nik.1 uc008nik.2 uc008nik.3 uc008nik.4 Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (By similarity). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (PubMed:15311282). May play a role in cell migration (PubMed:15311282). Homodimer (By similarity). Heterodimer with MAPRE3 (By similarity). Interacts (via C-terminal residues 206-211) with APC (via C-terminal residues 2674-2845); the interaction inhibits association with and bundling of F-actin (PubMed:15311282). Interacts with DCTN1, DIAPH1 and DIAPH2 (PubMed:15311282). Interacts with DCTN2, TERF1 and dynein intermediate chain (By similarity). Interacts with CLASP2, DST, KIF2C and STIM1; probably required for their targeting to the growing microtubule plus ends (By similarity). Interacts with MTUS2; interaction is direct and probably targets MTUS2 to microtubules (By similarity). Interacts with APC2 (By similarity). Interacts with CLASP1 (By similarity). Interacts (via C-terminus) with CLIP1 (By similarity). Interacts with SLAIN2 and SLAIN1 (PubMed:21646404). Interacts with MACF1 (PubMed:18854161). Interacts with KIF18B; this interaction is required for efficient accumulation of KIF18B at microtubule plus ends (By similarity). Interacts with MISP (By similarity). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (PubMed:23055941). Interacts with KCNAB2 (PubMed:21357749). Interacts with KNSTRN (By similarity). Interacts with NCKAP5L (By similarity). Interacts with AKAP9 (By similarity). Interacts with PDE4DIP isoform 2/MMG8/SMYLE; this interaction is required for its recruitment to the Golgi apparatus. May form a pericentrosomal complex with AKAP9, CDK5RAP2 and PDE4DIP isoform 2/MMG8/SMYLE; within this complex, MAPRE1 binding to CDK5RAP2 may be mediated by PDE4DIP (By similarity). Contrary to other mammalian species, does not interact with CDK5RAP2, possibly due to the lack of conservation of the MAPRE1-binding motif in mouse CDK5RAP2 (PubMed:19553473). Interacts with AKNA (PubMed:30787442). Interacts with GAS2L1, GAS2L2, and GAS2L3 (PubMed:24706950). Interacts with RARRES1 and AGBL2 (By similarity). Q61166; P14873: Map1b; NbExp=5; IntAct=EBI-2027055, EBI-764653; Q61166; Q03001: DST; Xeno; NbExp=4; IntAct=EBI-2027055, EBI-310758; Cytoplasm, cytoskeleton toplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=Associated with the microtubule network at the growing distal tip of microtubules (PubMed:21357749). Also enriched at the centrosome (By similarity). Expressed within the midpiece of sperm tail (at protein level). Composed of two functionally independent domains. The N- terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1. Acetylation at Lys-220 by KAT2B/PCAF promotes dynamic kinetochore- microtubule interactions in early mitosis. Crotonylated by KAT5 during mitosis, promoting astral microtubule plasticity and dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation, thereby ensuring accurate spindle positioning in mitosis. Decrotonylated by HDAC3. Belongs to the MAPRE family. Sequence=AAH52405.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; microtubule bundle formation protein binding cytoplasm Golgi apparatus centrosome microtubule organizing center spindle cytoskeleton microtubule cytoplasmic microtubule focal adhesion cell cycle microtubule binding microtubule cytoskeleton cell migration protein kinase binding cortical microtubule cytoskeleton regulation of microtubule polymerization or depolymerization negative regulation of microtubule polymerization positive regulation of microtubule polymerization cell projection membrane microtubule plus-end protein localization to microtubule identical protein binding cell projection microtubule polymerization microtubule plus-end binding spindle assembly spindle midzone cell division positive regulation of microtubule plus-end binding protein localization to microtubule plus-end mitotic spindle astral microtubule end uc008nik.1 uc008nik.2 uc008nik.3 uc008nik.4 
ENSMUST00000028982.5 Sun5 ENSMUST00000028982.5 Sad1 and UNC84 domain containing 5, transcript variant 2 (from RefSeq NM_029599.3) A0A0R4J084 A0A0R4J084_MOUSE ENSMUST00000028982.1 ENSMUST00000028982.2 ENSMUST00000028982.3 ENSMUST00000028982.4 NM_029599 Sun5 uc008nim.1 uc008nim.2 uc008nim.3 nuclear inner membrane spermatogenesis sperm connecting piece uc008nim.1 uc008nim.2 uc008nim.3 
ENSMUST00000028983.3 Bpifb2 ENSMUST00000028983.3 BPI fold containing family B, member 2 (from RefSeq NM_025631.3) BPIB2_MOUSE Bpil1 ENSMUST00000028983.1 ENSMUST00000028983.2 NM_025631 Q3TUY4 Q8BVZ0 Q8C1E1 Q8C1E2 Q9D713 Q9D744 uc008nin.1 uc008nin.2 uc008nin.3 Secreted Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. extracellular region biological_process lipid binding uc008nin.1 uc008nin.2 uc008nin.3 
ENSMUST00000028984.13 Bpifa3 ENSMUST00000028984.13 BPI fold containing family A, member 3, transcript variant 1 (from RefSeq NM_028528.3) 1700058C13Rik Bpifa3 ENSMUST00000028984.1 ENSMUST00000028984.10 ENSMUST00000028984.11 ENSMUST00000028984.12 ENSMUST00000028984.2 ENSMUST00000028984.3 ENSMUST00000028984.4 ENSMUST00000028984.5 ENSMUST00000028984.6 ENSMUST00000028984.7 ENSMUST00000028984.8 ENSMUST00000028984.9 NM_028528 Q80X83 Q80X83_MOUSE uc008nit.1 uc008nit.2 uc008nit.3 uc008nit.4 lipid binding uc008nit.1 uc008nit.2 uc008nit.3 uc008nit.4 
ENSMUST00000028985.8 Bpifa1 ENSMUST00000028985.8 BPI fold containing family A, member 1 (from RefSeq NM_011126.3) BPIA1_MOUSE ENSMUST00000028985.1 ENSMUST00000028985.2 ENSMUST00000028985.3 ENSMUST00000028985.4 ENSMUST00000028985.5 ENSMUST00000028985.6 ENSMUST00000028985.7 NM_011126 P97361 Plunc Q7TQJ2 Splunc1 uc008niu.1 uc008niu.2 uc008niu.3 uc008niu.4 Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (By similarity). Plays a role in the innate immune responses of the upper airways (PubMed:23499554). Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23499554). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (By similarity). Plays a role in the airway inflammatory response after exposure to irritants (By similarity). May attract macrophages and neutrophils (By similarity). Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium channel (ENaC); this inhibits proteolytic activation of ENaC (By similarity). Secreted Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum. Detected in airway epithelia (trachea and lung) and in bronchoalveolar fluid (at protein level). Upper airways, nasopharyngeal epithelium and thymus. Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. No expression is detected in the terminal bronchioles, respiratory bronchioles or lung alveoli. First detected at 14.5 dpc in the nasopharyngeal epithelium and persists there into adulthood. In the thymus, weak expression is detected at 16.5 dpc and appears to be restricted to epithelial cells lining the medullary venules. This pattern of thymic expression persists until birth and into early postnatal life but is greatly decreased in the adult thymus. No expression is detected in the lung until 2 days after birth, after which expression is detected in cells lining the trachea. Belongs to the BPI/LBP/Plunc superfamily. Plunc family. Reported to bind to bacterial lipopolysaccharide (LPS) in vitro. However, the in vivo significance of this is uncertain since other studies indicate little or no specificity for LPS. immune system process molecular_function extracellular region extracellular space microvillus lipid binding antibacterial humoral response defense response to bacterium innate immune response regulation of liquid surface tension multicellular organismal water homeostasis negative regulation of single-species biofilm formation in or on host organism regulation of sodium ion transmembrane transport uc008niu.1 uc008niu.2 uc008niu.3 uc008niu.4 
ENSMUST00000028986.3 Bpifa5 ENSMUST00000028986.3 BPI fold containing family A, member 5 (from RefSeq NM_025990.4) A2ARM4 BPIA5_MOUSE ENSMUST00000028986.1 ENSMUST00000028986.2 NM_025990 Pluncl Q14BY9 Q8CIW0 Q9CQX3 Q9D6P0 Q9D794 Splunc5 uc008niv.1 uc008niv.2 uc008niv.3 uc008niv.4 May play a role in innate immunity in the oral cavity. Secreted Expressed in interpapillar epithelium of the anterior part of the tongue. Expressed in juvenile and adult mice from postnatal day 2. Belongs to the BPI/LBP/Plunc superfamily. Plunc family. cellular_component extracellular region biological_process lipid binding uc008niv.1 uc008niv.2 uc008niv.3 uc008niv.4 
ENSMUST00000028995.5 Fam210b ENSMUST00000028995.5 family with sequence similarity 210, member B (from RefSeq NM_025912.4) ENSMUST00000028995.1 ENSMUST00000028995.2 ENSMUST00000028995.3 ENSMUST00000028995.4 F210B_MOUSE Fam210b NM_025912 Q3UFZ3 Q91WA2 Q9D8B6 uc012ckn.1 uc012ckn.2 uc012ckn.3 Plays a role in erythroid differentiation. Involved in cell proliferation and tumor cell growth suppression. Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner. Mitochondrion Mitochondrion outer membrane ; Multi-pass membrane protein Expressed in late erythroblast differentiation stages (PubMed:26968549). Up-regulated by the erythroid transcription factor GATA1 (PubMed:26968549). Belongs to the FAM210 family. molecular_function mitochondrion mitochondrial outer membrane membrane integral component of membrane cell differentiation intrinsic component of membrane erythrocyte maturation positive regulation of erythrocyte differentiation cellular response to estradiol stimulus uc012ckn.1 uc012ckn.2 uc012ckn.3 
ENSMUST00000028999.12 Pkia ENSMUST00000028999.12 protein kinase inhibitor, alpha, transcript variant 1 (from RefSeq NM_008862.4) ENSMUST00000028999.1 ENSMUST00000028999.10 ENSMUST00000028999.11 ENSMUST00000028999.2 ENSMUST00000028999.3 ENSMUST00000028999.4 ENSMUST00000028999.5 ENSMUST00000028999.6 ENSMUST00000028999.7 ENSMUST00000028999.8 ENSMUST00000028999.9 IPKA_MOUSE NM_008862 P27776 P63248 Q3UTL0 uc008oof.1 uc008oof.2 uc008oof.3 uc008oof.4 Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. P63248; P05132: Prkaca; NbExp=4; IntAct=EBI-2931786, EBI-400564; Present at high levels in skeletal muscle and brain but is present at lower levels in heart, testis and liver. The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and 'pseudosubstrate site' of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site (By similarity). Belongs to the PKI family. negative regulation of transcription from RNA polymerase II promoter protein kinase inhibitor activity cAMP-dependent protein kinase inhibitor activity protein binding nucleus cytoplasm negative regulation of protein kinase activity regulation of G2/M transition of mitotic cell cycle protein kinase A catalytic subunit binding negative regulation of protein import into nucleus negative regulation of catalytic activity negative regulation of cAMP-dependent protein kinase activity uc008oof.1 uc008oof.2 uc008oof.3 uc008oof.4 
ENSMUST00000029002.9 Stmn2 ENSMUST00000029002.9 stathmin-like 2 (from RefSeq NM_025285.2) ENSMUST00000029002.1 ENSMUST00000029002.2 ENSMUST00000029002.3 ENSMUST00000029002.4 ENSMUST00000029002.5 ENSMUST00000029002.6 ENSMUST00000029002.7 ENSMUST00000029002.8 NM_025285 Q545S4 Q545S4_MOUSE Stmn2 uc008ooo.1 uc008ooo.2 uc008ooo.3 Cell projection, lamellipodium Cytoplasm Membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the stathmin family. cytoplasm Golgi apparatus negative regulation of microtubule depolymerization positive regulation of neuron projection development negative regulation of neuron projection development lamellipodium growth cone regulation of microtubule polymerization or depolymerization negative regulation of microtubule polymerization positive regulation of microtubule depolymerization vesicle neuron projection neuronal cell body calcium-dependent protein binding perinuclear region of cytoplasm cellular response to nerve growth factor stimulus uc008ooo.1 uc008ooo.2 uc008ooo.3 
ENSMUST00000029005.4 Rtf2 ENSMUST00000029005.4 replication termination factor 2 (from RefSeq NM_025542.2) A2APA0 ENSMUST00000029005.1 ENSMUST00000029005.2 ENSMUST00000029005.3 NM_025542 Q543D3 Q80X88 Q99K95 Q9CV27 RTF2_MOUSE Rtf2 Rtfdc1 uc008ocw.1 uc008ocw.2 uc008ocw.3 Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Interacts with DDI2; probably also interacts with DDI1. Chromosome Note=Localizes at the replication fork. Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from stalled replisomes and degradation are required for genome stability. Belongs to the rtf2 family. DNA binding nucleus replication fork chromosome site-specific DNA replication termination at RTS1 barrier cellular response to hydroxyurea mitotic DNA replication termination uc008ocw.1 uc008ocw.2 uc008ocw.3 
ENSMUST00000029007.3 Fam209 ENSMUST00000029007.3 family with sequence similarity 209 (from RefSeq NM_029608.1) A2APA5 ENSMUST00000029007.1 ENSMUST00000029007.2 FA209_MOUSE Fam209 NM_029608 Q9D9T2 uc008ocy.1 uc008ocy.2 uc008ocy.3 uc008ocy.4 Required for sperm acrosome biogenesis. Interacts with DPY19L2. Nucleus inner membrane ; Single-pass type I membrane protein Predominately expressed in testis. Detectable at postnatal day 20 when round spermatids begin to appear. molecular_function biological_process membrane integral component of membrane uc008ocy.1 uc008ocy.2 uc008ocy.3 uc008ocy.4 
ENSMUST00000029013.10 Rae1 ENSMUST00000029013.10 ribonucleic acid export 1 (from RefSeq NM_175112.5) ENSMUST00000029013.1 ENSMUST00000029013.2 ENSMUST00000029013.3 ENSMUST00000029013.4 ENSMUST00000029013.5 ENSMUST00000029013.6 ENSMUST00000029013.7 ENSMUST00000029013.8 ENSMUST00000029013.9 Mrnp41 NM_175112 Q3UKD4 Q8C570 RAE1L_MOUSE uc008odg.1 uc008odg.2 uc008odg.3 Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Interacts with NUMA1 (via N-terminal end of the coiled-coil domain); this interaction promotes spindle formation in mitosis (By similarity). Interacts with NUP98 (PubMed:10209021). Interacts with MYCBP2 (By similarity). Interacts with USP11 (By similarity). Cytoplasm Nucleus Cytoplasm, cytoskeleton, spindle pole Note=Recruited from interphase nuclei to spindle MTs during mitosis. Belongs to the WD repeat rae1 family. spindle pole transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery fibrillar center RNA binding nucleus nuclear envelope nuclear pore cytoplasm cytoskeleton mRNA export from nucleus cell cycle ubiquitin binding cell division regulation of mitotic spindle organization cellular response to organic cyclic compound mitotic spindle pole uc008odg.1 uc008odg.2 uc008odg.3 
ENSMUST00000029017.6 Pck1 ENSMUST00000029017.6 phosphoenolpyruvate carboxykinase 1, cytosolic (from RefSeq NM_011044.3) ENSMUST00000029017.1 ENSMUST00000029017.2 ENSMUST00000029017.3 ENSMUST00000029017.4 ENSMUST00000029017.5 NM_011044 PCKGC_MOUSE Pck1 Pepck Q3UEH3 Q9Z2V4 uc008odn.1 uc008odn.2 uc008odn.3 uc008odn.4 Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis (PubMed:11916968, PubMed:11792850, PubMed:30193097, PubMed:29230018). Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle (PubMed:30193097). At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate- limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:30193097). At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate (PubMed:30193097). Acts as a regulator of formation and maintenance of memory CD8(+) T- cells: up-regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis (PubMed:29230018). The resultant phosphoenolpyruvate flows to glycogen and pentose phosphate pathway, which is essential for memory CD8(+) T-cells homeostasis (PubMed:29230018). In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor (By similarity). The protein kinase activity regulates lipogenesis: upon phosphorylation at Ser-90, translocates to the endoplasmic reticulum and catalyzes phosphorylation of INSIG proteins (INSIG1 and INSIG2), thereby disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes (By similarity). Reaction=GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate; Xref=Rhea:RHEA:10388, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526, ChEBI:CHEBI:37565, ChEBI:CHEBI:58189, ChEBI:CHEBI:58702; EC=4.1.1.32; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10389; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:10390; Evidence=; Reaction=GTP + L-seryl-[protein] = GDP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:64020, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:37565, ChEBI:CHEBI:58189, ChEBI:CHEBI:83421; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64021; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mn(2+) ion per subunit. ; Phosphoenolpyruvate carboxykinase activity is regulated by acetylation and glucose levels (PubMed:30193097). The anaplerotic conversion of phosphoenolpyruvate to oxaloacetate is improved by PCK1 acetylation on Lys-91 (K91ac), Lys-473 (K473ac) and Lys-521 (K521ac) (By similarity). High glucose concentrations favor PCK1 anaplerotic activity by triggering acetylation on Lys-91 (K91ac). At low glucose levels, SIRT1-mediated deacetylation of Lys-91 promotes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (By similarity). Phosphorylation at Ser-90 reduces the binding affinity to oxaloacetate and converts the enzyme into an atypical protein kinase using GTP as donor (By similarity). Carbohydrate biosynthesis; gluconeogenesis. Monomer. Cytoplasm, cytosol Endoplasmic reticulum Note=Phosphorylation at Ser-90 promotes translocation to the endoplasmic reticulum. Expression is repressed by ATF3 (PubMed:11916968). Expression is regulated by glucocortinoids and insulin (PubMed:16100117). Up-regulated in CD8(+) memory T-cells (PubMed:29230018). Acetylated (PubMed:30193097). Lysine acetylation by p300/EP300 is increased on high glucose conditions and promotes ubiquitination by UBR5, acetylation is enhanced in the presence of BAG6. Deacetylated by SIRT2 (By similarity). Deacetylated by SIRT1 (PubMed:30193097). Ubiquitination by UBR5 leads to proteasomal degradation. Phosphorylated in a GSK3B-mediated pathway; phosphorylation affects the efficiency of SIRT1-mediated deacetylation, and regulates PCK1 ubiquitination and degradation. Phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes the protein kinase activity: phosphorylated PCK1 translocates to the endoplasmic reticulum, where it phosphorylates INSIG1 and INSIG2. Mice do not survive beyond 2 to 3 days after birth. In eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one. Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. nucleotide binding magnesium ion binding nucleoside diphosphate kinase activity phosphoenolpyruvate carboxykinase activity phosphoenolpyruvate carboxykinase (GTP) activity GTP binding cytoplasm mitochondrion cytosol glucose metabolic process pyruvate metabolic process gluconeogenesis oxaloacetate metabolic process nucleoside diphosphate phosphorylation internal protein amino acid acetylation lipid metabolic process aging response to bacterium response to activity lyase activity carboxy-lyase activity purine nucleotide binding GDP binding propionate catabolic process manganese ion binding carboxylic acid binding response to lipopolysaccharide response to insulin cellular response to insulin stimulus response to lipid glucose homeostasis response to starvation glycerol biosynthetic process from pyruvate metal ion binding cellular response to potassium ion starvation positive regulation of transcription from RNA polymerase II promoter in response to acidic pH hepatocyte differentiation response to interleukin-6 cellular response to retinoic acid cellular response to cAMP cellular response to fructose stimulus cellular response to glucose stimulus cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to glucagon stimulus cellular response to hypoxia cellular response to dexamethasone stimulus response to methionine uc008odn.1 uc008odn.2 uc008odn.3 uc008odn.4 
ENSMUST00000029018.14 Zbp1 ENSMUST00000029018.14 Z-DNA binding protein 1, transcript variant 1 (from RefSeq NM_021394.2) A2APF7 A2APF7_MOUSE ENSMUST00000029018.1 ENSMUST00000029018.10 ENSMUST00000029018.11 ENSMUST00000029018.12 ENSMUST00000029018.13 ENSMUST00000029018.2 ENSMUST00000029018.3 ENSMUST00000029018.4 ENSMUST00000029018.5 ENSMUST00000029018.6 ENSMUST00000029018.7 ENSMUST00000029018.8 ENSMUST00000029018.9 NM_021394 Zbp1 uc008odo.1 uc008odo.2 uc008odo.3 uc008odo.4 uc008odo.5 A2APF7; Q13363: CTBP1; Xeno; NbExp=2; IntAct=EBI-6115394, EBI-908846; A2APF7; P56545: CTBP2; Xeno; NbExp=2; IntAct=EBI-6115394, EBI-741533; A2APF7; Q9ULE6: PALD1; Xeno; NbExp=2; IntAct=EBI-6115394, EBI-3957166; A2APF7; Q6UX71: PLXDC2; Xeno; NbExp=2; IntAct=EBI-6115394, EBI-6115410; A2APF7; Q13114: TRAF3; Xeno; NbExp=2; IntAct=EBI-6115394, EBI-357631; DNA binding protein binding positive regulation of type I interferon-mediated signaling pathway uc008odo.1 uc008odo.2 uc008odo.3 uc008odo.4 uc008odo.5 
ENSMUST00000029023.4 Cimip1 ENSMUST00000029023.4 ciliary microtubule inner protein 1 (from RefSeq NM_028158.1) CMIP1_MOUSE ENSMUST00000029023.1 ENSMUST00000029023.2 ENSMUST00000029023.3 NM_028158 Q80YT4 Q9DA42 uc008odt.1 uc008odt.2 uc008odt.3 uc008odt.4 Cell projection, cilium molecular_function cellular_component biological_process uc008odt.1 uc008odt.2 uc008odt.3 uc008odt.4 
ENSMUST00000029024.10 Rab22a ENSMUST00000029024.10 RAB22A, member RAS oncogene family (from RefSeq NM_024436.3) ENSMUST00000029024.1 ENSMUST00000029024.2 ENSMUST00000029024.3 ENSMUST00000029024.4 ENSMUST00000029024.5 ENSMUST00000029024.6 ENSMUST00000029024.7 ENSMUST00000029024.8 ENSMUST00000029024.9 NM_024436 Q0PD34 Q0PD34_MOUSE Rab22A Rab22a uc008oeg.1 uc008oeg.2 uc008oeg.3 uc008oeg.4 Membrane ; Lipid- anchor ; Cytoplasmic side Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding early endosome plasma membrane endocytosis endosome organization GDP binding phagocytic vesicle regulation of vesicle size uc008oeg.1 uc008oeg.2 uc008oeg.3 uc008oeg.4 
ENSMUST00000029030.9 Edn3 ENSMUST00000029030.9 endothelin 3 (from RefSeq NM_007903.5) EDN3_MOUSE ENSMUST00000029030.1 ENSMUST00000029030.2 ENSMUST00000029030.3 ENSMUST00000029030.4 ENSMUST00000029030.5 ENSMUST00000029030.6 ENSMUST00000029030.7 ENSMUST00000029030.8 NM_007903 P48299 Q543L0 uc008ofi.1 uc008ofi.2 uc008ofi.3 uc008ofi.4 This gene is a member of the endothelin family whose members encode proteins that act on G protein-coupled receptors. Endothelins are produced as large prepropolypeptide precursors that undergo a first cleavage by a subtilisin serine protease to form an inactive intermediate, which in turn is cleaved again by endothelin-converting enzyme 1 (ECE-1) to yield the active 21 amino acid peptide. This gene encodes a protein which is expressed in neural crest cells (NCC), binds to endothelin receptor b (Ednrb) and plays an essential role in the development of NCC-derived cell lineages including melanocytes and enteric neurons. Mutations in this gene are associated with terminal aganglionosis and white spotted coat in mice and Hirschsprung's disease and Waardenburg syndrome in humans. [provided by RefSeq, Apr 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK049775.1, BC137727.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Endothelins are endothelium-derived vasoconstrictor peptides. Secreted. Belongs to the endothelin/sarafotoxin family. neural crest cell migration positive regulation of leukocyte chemotaxis regulation of systemic arterial blood pressure by endothelin hormone activity extracellular region extracellular space cell cellular calcium ion homeostasis cell surface receptor signaling pathway positive regulation of cell proliferation positive regulation of heart rate regulation of gene expression cellular magnesium ion homeostasis vein smooth muscle contraction regulation of vasoconstriction peptide hormone secretion neuron differentiation melanocyte differentiation regulation of cell migration neutrophil chemotaxis endothelin B receptor binding vasoconstriction positive regulation of MAP kinase activity positive regulation of cell differentiation positive regulation of mitotic nuclear division positive regulation of hormone secretion negative regulation of hormone secretion regulation of neurotransmitter secretion inositol phosphate-mediated signaling regulation of developmental pigmentation positive regulation of potassium ion transmembrane transport uc008ofi.1 uc008ofi.2 uc008ofi.3 uc008ofi.4 
ENSMUST00000029034.9 Pmp2 ENSMUST00000029034.9 peripheral myelin protein 2 (from RefSeq NM_001030305.2) ENSMUST00000029034.1 ENSMUST00000029034.2 ENSMUST00000029034.3 ENSMUST00000029034.4 ENSMUST00000029034.5 ENSMUST00000029034.6 ENSMUST00000029034.7 ENSMUST00000029034.8 MYP2_MOUSE NM_001030305 P24526 Q4KL10 uc008oph.1 uc008oph.2 uc008oph.3 May play a role in lipid transport protein in Schwann cells. May bind cholesterol (By similarity). Monomer. Cytoplasm Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. fatty acid binding cytoplasm lipid binding cholesterol binding myelin sheath membrane organization uc008oph.1 uc008oph.2 uc008oph.3 
ENSMUST00000029038.8 Fabp9 ENSMUST00000029038.8 fatty acid binding protein 9, testis (from RefSeq NM_011598.3) ENSMUST00000029038.1 ENSMUST00000029038.2 ENSMUST00000029038.3 ENSMUST00000029038.4 ENSMUST00000029038.5 ENSMUST00000029038.6 ENSMUST00000029038.7 FABP9_MOUSE NM_011598 O08716 Perf15 Q9DAL2 Tlbp uc290dvh.1 uc290dvh.2 Cytoplasm Testis. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. acrosomal vesicle cytoplasm lipid binding uc290dvh.1 uc290dvh.2 
ENSMUST00000029041.6 Fabp4 ENSMUST00000029041.6 fatty acid binding protein 4, adipocyte, transcript variant 1 (from RefSeq NM_024406.4) ENSMUST00000029041.1 ENSMUST00000029041.2 ENSMUST00000029041.3 ENSMUST00000029041.4 ENSMUST00000029041.5 Fabp4 NM_024406 Q542H7 Q542H7_MOUSE uc008opl.1 uc008opl.2 uc008opl.3 uc008opl.4 uc008opl.5 Cytoplasm Nucleus Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. fatty acid binding lipid binding regulation of inflammatory response uc008opl.1 uc008opl.2 uc008opl.3 uc008opl.4 uc008opl.5 
ENSMUST00000029043.13 Fabp12 ENSMUST00000029043.13 fatty acid binding protein 12, transcript variant 2 (from RefSeq NM_029310.1) B7SUM9 ENSMUST00000029043.1 ENSMUST00000029043.10 ENSMUST00000029043.11 ENSMUST00000029043.12 ENSMUST00000029043.2 ENSMUST00000029043.3 ENSMUST00000029043.4 ENSMUST00000029043.5 ENSMUST00000029043.6 ENSMUST00000029043.7 ENSMUST00000029043.8 ENSMUST00000029043.9 FBP12_MOUSE NM_029310 Q9DAK4 uc008opn.1 uc008opn.2 May play a role in lipid transport. Highly expressed in adult retina and testis. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. cellular_component biological_process lipid binding uc008opn.1 uc008opn.2 
ENSMUST00000029046.9 Fabp5 ENSMUST00000029046.9 fatty acid binding protein 5, epidermal, transcript variant 1 (from RefSeq NM_010634.3) ENSMUST00000029046.1 ENSMUST00000029046.2 ENSMUST00000029046.3 ENSMUST00000029046.4 ENSMUST00000029046.5 ENSMUST00000029046.6 ENSMUST00000029046.7 ENSMUST00000029046.8 Fabp5 NM_010634 Q497I3 Q497I3_MOUSE uc008opg.1 uc008opg.2 uc008opg.3 uc008opg.4 The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. In humans this gene has been associated with psoriasis and type 2 diabetes. In mouse deficiency of this gene in combination with a deficiency in Fabp4 confers protection against atherosclerosis, diet-induced obesity, insulin resistance and experimental autoimmune encephalomyelitis (the mouse model for multiple sclerosis). Alternative splicing results in multiple transcript variants that encode different protein isoforms. The mouse genome contains many pseudogenes similar to this locus. [provided by RefSeq, Jan 2013]. Reaction=(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in); Xref=Rhea:RHEA:33655, ChEBI:CHEBI:30823; Evidence=; Reaction=(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)- octadecadienoate(in); Xref=Rhea:RHEA:45264, ChEBI:CHEBI:30245; Evidence=; Reaction=hexadecanoate(out) = hexadecanoate(in); Xref=Rhea:RHEA:45256, ChEBI:CHEBI:7896; Evidence=; Cytoplasm Nucleus Postsynaptic density Secreted Synapse Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. fatty acid binding nucleus cytoplasm lipid binding identical protein binding uc008opg.1 uc008opg.2 uc008opg.3 uc008opg.4 
ENSMUST00000029047.12 Snx16 ENSMUST00000029047.12 sorting nexin 16, transcript variant 1 (from RefSeq NM_029068.4) ENSMUST00000029047.1 ENSMUST00000029047.10 ENSMUST00000029047.11 ENSMUST00000029047.2 ENSMUST00000029047.3 ENSMUST00000029047.4 ENSMUST00000029047.5 ENSMUST00000029047.6 ENSMUST00000029047.7 ENSMUST00000029047.8 ENSMUST00000029047.9 NM_029068 Q8C080 Q9D525 SNX16_MOUSE uc008opw.1 uc008opw.2 uc008opw.3 uc008opw.4 uc008opw.5 May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling (By similarity). Homooligomer. Interacts with EGFR (By similarity). Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm Lysosome The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate. Belongs to the sorting nexin family. cytoplasm lysosome endosome early endosome late endosome cytosol protein targeting to lysosome lipid binding endosome to lysosome transport protein transport membrane extrinsic component of endosome membrane early endosome membrane late endosome membrane phosphatidylinositol binding identical protein binding intracellular membrane-bounded organelle early endosome to late endosome transport uc008opw.1 uc008opw.2 uc008opw.3 uc008opw.4 uc008opw.5 
ENSMUST00000029049.7 Chmp4c ENSMUST00000029049.7 charged multivesicular body protein 4C (from RefSeq NM_025519.2) CHM4C_MOUSE ENSMUST00000029049.1 ENSMUST00000029049.2 ENSMUST00000029049.3 ENSMUST00000029049.4 ENSMUST00000029049.5 ENSMUST00000029049.6 NM_025519 Q149R2 Q3TVD7 Q9CWH8 Q9D7F7 uc008opv.1 uc008opv.2 uc008opv.3 Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Self-associates. Interacts with CHMP2A. Interacts with CHMP4A. Interacts with CHMP4B. Interacts with CHMP6. Interacts with VPS4A. Interacts with PDCD6IP; the interaction is direct (By similarity). Cytoplasm, cytosol Late endosome membrane ; Peripheral membrane protein Midbody, Midbody ring Note=Localizes to the midbody during late cytokinesis. During its recruitment, localizes initially to the midbody arms, before being directed to the central region, the midbody ring, also called Flemming body. Phosphorylation at Ser-210 by AURKB triggers localization to midbody ring. The acidic C-terminus and the basic N-terminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity). Phosphorylated at Ser-210 by AURKB during cytokinesis: together with ZFYVE19/ANCHR, phosphorylated CHMP4C retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Belongs to the SNF7 family. cytoplasm endosome cytosol nucleus organization vacuolar transport mitotic metaphase plate congression abscission regulation of centrosome duplication protein transport membrane midbody late endosome membrane negative regulation of cytokinesis protein homodimerization activity mitotic cytokinesis checkpoint regulation of viral process Flemming body ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway regulation of mitotic spindle assembly positive regulation of viral release from host cell uc008opv.1 uc008opv.2 uc008opv.3 
ENSMUST00000029053.8 Ptpn1 ENSMUST00000029053.8 protein tyrosine phosphatase, non-receptor type 1 (from RefSeq NM_011201.3) ENSMUST00000029053.1 ENSMUST00000029053.2 ENSMUST00000029053.3 ENSMUST00000029053.4 ENSMUST00000029053.5 ENSMUST00000029053.6 ENSMUST00000029053.7 NM_011201 Ptpn1 Q3TZW9 Q3TZW9_MOUSE uc008oaj.1 uc008oaj.2 Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 1 subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity insulin receptor binding early endosome endoplasmic reticulum cytosol plasma membrane protein dephosphorylation zinc ion binding regulation of signal transduction membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity enzyme binding protein kinase binding regulation of endocytosis endoplasmic reticulum unfolded protein response receptor tyrosine kinase binding cytoplasmic vesicle actin cytoskeleton reorganization macromolecular complex regulation of intracellular protein transport peptidyl-tyrosine dephosphorylation platelet-derived growth factor receptor-beta signaling pathway negative regulation of MAP kinase activity regulation of insulin receptor signaling pathway ephrin receptor binding protein phosphatase 2A binding positive regulation of protein tyrosine kinase activity cytoplasmic side of endoplasmic reticulum membrane regulation of hepatocyte growth factor receptor signaling pathway negative regulation of PERK-mediated unfolded protein response positive regulation of receptor catabolic process uc008oaj.1 uc008oaj.2 
ENSMUST00000029061.12 Sall4 ENSMUST00000029061.12 spalt like transcription factor 4, transcript variant a (from RefSeq NM_175303.5) A2AV00 ENSMUST00000029061.1 ENSMUST00000029061.10 ENSMUST00000029061.11 ENSMUST00000029061.2 ENSMUST00000029061.3 ENSMUST00000029061.4 ENSMUST00000029061.5 ENSMUST00000029061.6 ENSMUST00000029061.7 ENSMUST00000029061.8 ENSMUST00000029061.9 NM_175303 Q6S7E8 Q6S7E9 Q7TST6 Q8BX22 SALL4_MOUSE uc008obf.1 uc008obf.2 This gene belongs to the spalt family of zinc finger transcription factors. In mouse, functions for this gene have been described in many embryonic developmental processes, including brain, heart, and limb development. In addition, this gene is an important pluripotency factor that is required for stem cell maintenance. Homozygous mutant mice display embryonic lethality, while conditional knock-out in embryonic germ cells results in failure to establish a robust stem cell population. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells. Interacts with POU5F1/OCT4 (By similarity). Interacts with NANOG (PubMed:16840789). Interacts with BEND3 (By similarity). Interacts with NSD2 (via PHD-type zinc fingers 1, 2 and 3) (PubMed:19483677). Interacts with NRBP1 (PubMed:22510880). Q8BX22; Q9R190: Mta2; NbExp=3; IntAct=EBI-2312582, EBI-904134; Q8BX22; Q7TSZ8: Nacc1; NbExp=4; IntAct=EBI-2312582, EBI-5691985; Q8BX22; Q8BVE8-2: Nsd2; NbExp=3; IntAct=EBI-2312582, EBI-11518042; Q8BX22; O70230: Znf143; NbExp=2; IntAct=EBI-2312582, EBI-5691478; Q8BX22; Q9UHY1: NRBP1; Xeno; NbExp=2; IntAct=EBI-2312582, EBI-749731; Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Sall4a; IsoId=Q8BX22-1; Sequence=Displayed; Name=2; Synonyms=Sall4b; IsoId=Q8BX22-2; Sequence=VSP_021687; Name=3; Synonyms=Sall4c; IsoId=Q8BX22-3; Sequence=VSP_021686; Expressed in the embryonic heart (at protein level). Sumoylation with both SUMO1 and SUMO2 regulates the stability, subcellular localization, transcriptional activity, and may reduce interaction with POU5F1/OCT4. Belongs to the sal C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter heterochromatin in utero embryonic development inner cell mass cell proliferation neural tube closure ventricular septum development nucleic acid binding DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm regulation of transcription, DNA-templated heart development transcription factor binding tissue development stem cell population maintenance neural tube development embryonic limb morphogenesis macromolecular complex intracellular membrane-bounded organelle positive regulation of transcription from RNA polymerase II promoter metal ion binding uc008obf.1 uc008obf.2 
ENSMUST00000029069.13 E2f5 ENSMUST00000029069.13 E2F transcription factor 5 (from RefSeq NM_007892.3) E2F5_MOUSE ENSMUST00000029069.1 ENSMUST00000029069.10 ENSMUST00000029069.11 ENSMUST00000029069.12 ENSMUST00000029069.2 ENSMUST00000029069.3 ENSMUST00000029069.4 ENSMUST00000029069.5 ENSMUST00000029069.6 ENSMUST00000029069.7 ENSMUST00000029069.8 ENSMUST00000029069.9 NM_007892 Q61502 Q99LK0 uc008oqk.1 uc008oqk.2 uc008oqk.3 Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interaction with retinoblastoma protein RB1 or proteins RBL1 and RBL2 inhibits the E2F transactivation domain. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (By similarity). Q61502; Q64163-4: Tfdp2; NbExp=2; IntAct=EBI-7225685, EBI-8077763; Nucleus. In the developing epidermis, first detected in 13.5-14.5 dpc embryos. With the appearance of stratified epithelium, levels of E2F5 expression increase and by 16.5 dpc, high expression found in the suprabasal cell layers. High expression also found in other regions with stratified squamous epithelia including the developing palate, lip and tongue. In the developing nervous system, first detected in the forebrain at 9.5 dpc. At 10.5 dpc, strongly expressed in the rostral region of the spinal cord. By 11.5 dpc, E2F5 is expressed throughout the developing central nervous system. In 12.5- 15.5 dpc embryos, expression found in the undifferentiated ventricular regions of the brain. In the retina, expressed, in 14.5-18.5 dpc embryos, in the retinoblastic cell layer. In other developing tissues, highly expressed in the choroid plexus. Also found in the kidney, liver, lung, heart and weakly, in developing skeletal muscle and chondrocytes. Belongs to the E2F/DP family. G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding fibrillar center DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nuclear envelope nucleoplasm transcription factor complex nucleolus cytoplasm regulation of transcription, DNA-templated transcription factor binding animal organ morphogenesis sarcoplasm cell projection organization sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter protein dimerization activity regulation of cell cycle RNA polymerase II transcription factor complex uc008oqk.1 uc008oqk.2 uc008oqk.3 
ENSMUST00000029071.9 Car13 ENSMUST00000029071.9 carbonic anhydrase 13 (from RefSeq NM_024495.5) CAH13_MOUSE Ca13 ENSMUST00000029071.1 ENSMUST00000029071.2 ENSMUST00000029071.3 ENSMUST00000029071.4 ENSMUST00000029071.5 ENSMUST00000029071.6 ENSMUST00000029071.7 ENSMUST00000029071.8 NM_024495 Q3UBM2 Q9D6N1 uc008oqo.1 uc008oqo.2 uc008oqo.3 Reversible hydration of carbon dioxide. Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt). Expressed in spleen, lung, kidney, heart, brain, skeletal muscle and testis. Belongs to the alpha-carbonic anhydrase family. carbonate dehydratase activity cytosol zinc ion binding lyase activity myelin sheath intracellular membrane-bounded organelle metal ion binding uc008oqo.1 uc008oqo.2 uc008oqo.3 
ENSMUST00000029075.5 Dok5 ENSMUST00000029075.5 docking protein 5, transcript variant 1 (from RefSeq NM_029761.4) DOK5_MOUSE ENSMUST00000029075.1 ENSMUST00000029075.2 ENSMUST00000029075.3 ENSMUST00000029075.4 NM_029761 Q8BRI3 Q91ZM9 Q9CSM6 uc008ocg.1 uc008ocg.2 uc008ocg.3 uc008ocg.4 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP. Specifically expressed in the brain, with a high specificity for neurons. In 12.5 dpc and 13 dpc embryos, it is expressed in the central nervous system, e.g. in the neural tube, the dorsal root and the cranial ganglion. PTB domain mediates receptor interaction. Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF. Belongs to the DOK family. Type B subfamily. protein binding transmembrane receptor protein tyrosine kinase signaling pathway neuron differentiation positive regulation of MAPK cascade regulation of neurotrophin TRK receptor signaling pathway uc008ocg.1 uc008ocg.2 uc008ocg.3 uc008ocg.4 
ENSMUST00000029076.6 Car3 ENSMUST00000029076.6 carbonic anhydrase 3 (from RefSeq NM_007606.3) CAH3_MOUSE Ca3 ENSMUST00000029076.1 ENSMUST00000029076.2 ENSMUST00000029076.3 ENSMUST00000029076.4 ENSMUST00000029076.5 NM_007606 P16015 Q9ERN8 uc008oqs.1 uc008oqs.2 uc008oqs.3 uc008oqs.4 Reversible hydration of carbon dioxide. Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Inhibited by acetazolamide. Cytoplasm Expressed at lower levels in adipose tissue from animals that were either genetically obese or had experimentally induced obesity. S-thiolated both by thiol-disulfide exchange with glutathione disulfide and by oxyradical-initiated S-thiolation with reduced glutathione. S-glutathionylated in hepatocytes under oxidative stress. Belongs to the alpha-carbonic anhydrase family. carbonate dehydratase activity cytoplasm cytosol response to oxidative stress zinc ion binding response to bacterium nickel cation binding dephosphorylation phosphatase activity lyase activity response to ethanol metal ion binding uc008oqs.1 uc008oqs.2 uc008oqs.3 uc008oqs.4 
ENSMUST00000029078.9 Car2 ENSMUST00000029078.9 carbonic anhydrase 2, transcript variant 1 (from RefSeq NM_009801.5) CAH2_MOUSE Ca2 ENSMUST00000029078.1 ENSMUST00000029078.2 ENSMUST00000029078.3 ENSMUST00000029078.4 ENSMUST00000029078.5 ENSMUST00000029078.6 ENSMUST00000029078.7 ENSMUST00000029078.8 NM_009801 P00920 Q6LDQ7 Q7TPE1 Q9DCT3 Q9DCY9 uc008oqt.1 uc008oqt.2 uc008oqt.3 uc008oqt.4 Catalyzes the reversible hydration of carbon dioxide (By similarity). Can also hydrate cyanamide to urea (By similarity). Involved in the regulation of fluid secretion into the anterior chamber of the eye (By similarity). Essential for bone resorption and osteoclast differentiation (By similarity). Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption (By similarity). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity). Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Evidence=; Reaction=urea = cyanamide + H2O; Xref=Rhea:RHEA:23056, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:16698; EC=4.2.1.69; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Inhibited by acetazolamide. Interacts with SLC4A4 (By similarity). Interaction with SLC4A7 regulates SLC4A7 transporter activity (By similarity). Interacts with SLC26A6 (By similarity). Cytoplasm Cell membrane Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells. Belongs to the alpha-carbonic anhydrase family. kidney development morphogenesis of an epithelium arylesterase activity carbonate dehydratase activity extracellular space cytoplasm cytosol plasma membrane microvillus regulation of pH zinc ion binding response to pH response to organic substance response to zinc ion carbon dioxide transport membrane basolateral plasma membrane lyase activity axon positive regulation of synaptic transmission, GABAergic positive regulation of cellular pH reduction angiotensin-activated signaling pathway odontogenesis of dentin-containing tooth myelin sheath response to estrogen regulation of anion transport apical part of cell positive regulation of osteoclast differentiation positive regulation of bone resorption metal ion binding secretion response to steroid hormone regulation of intracellular pH cellular response to fluid shear stress positive regulation of dipeptide transmembrane transport regulation of chloride transport uc008oqt.1 uc008oqt.2 uc008oqt.3 uc008oqt.4 
ENSMUST00000029080.5 Cypt12 ENSMUST00000029080.5 cysteine-rich perinuclear theca 12 (from RefSeq NM_029289.1) Cypt12 ENSMUST00000029080.1 ENSMUST00000029080.2 ENSMUST00000029080.3 ENSMUST00000029080.4 NM_029289 Q9DAR6 Q9DAR6_MOUSE uc012cnq.1 uc012cnq.2 uc012cnq.3 molecular_function cellular_component biological_process uc012cnq.1 uc012cnq.2 uc012cnq.3 
ENSMUST00000029082.9 Psma7 ENSMUST00000029082.9 proteasome subunit alpha 7, transcript variant 1 (from RefSeq NM_011969.2) ENSMUST00000029082.1 ENSMUST00000029082.2 ENSMUST00000029082.3 ENSMUST00000029082.4 ENSMUST00000029082.5 ENSMUST00000029082.6 ENSMUST00000029082.7 ENSMUST00000029082.8 NM_011969 PSA7_MOUSE Q9Z2U0 uc008oib.1 uc008oib.2 uc008oib.3 uc008oib.4 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:16857966, PubMed:22341445). PSMA7 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly (By similarity). Interacts with HIF1A (By similarity). Interacts with RAB7A (By similarity). Interacts with PRKN (By similarity). Interacts with ABL1 and ABL2 (By similarity). Interacts with EMAP2 (By similarity). Interacts with MAVS (By similarity). Cytoplasm Nucleus Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. Detected in liver (at protein level). Up-regulated in liver tumor tissues. Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks. Belongs to the peptidase T1A family. proteasome complex endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteolysis ubiquitin-dependent protein catabolic process peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, alpha-subunit complex identical protein binding proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process postsynapse uc008oib.1 uc008oib.2 uc008oib.3 uc008oib.4 
ENSMUST00000029084.9 Ntsr1 ENSMUST00000029084.9 neurotensin receptor 1 (from RefSeq NM_018766.2) ENSMUST00000029084.1 ENSMUST00000029084.2 ENSMUST00000029084.3 ENSMUST00000029084.4 ENSMUST00000029084.5 ENSMUST00000029084.6 ENSMUST00000029084.7 ENSMUST00000029084.8 NM_018766 NTR1_MOUSE Ntsr O88319 uc008ojg.1 uc008ojg.2 uc008ojg.3 G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis. Interacts (palmitoylated form) with GNA11. Cell membrane ; Multi-pass membrane protein Membrane raft Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembrane regions TM6 and TM7. N-glycosylated. Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment. Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily. temperature homeostasis negative regulation of systemic arterial blood pressure regulation of membrane depolarization G-protein coupled receptor activity cytoplasm mitochondrion endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway learning neuropeptide receptor activity adult locomotory behavior cytoplasmic side of plasma membrane cell surface positive regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion membrane integral component of membrane G-protein coupled neurotensin receptor activity axon dendrite symmetric synapse response to lipid identical protein binding protein homodimerization activity neuronal cell body positive regulation of apoptotic process negative regulation of apoptotic process terminal bouton dendritic spine dendritic shaft perikaryon regulation of respiratory gaseous exchange axon terminus neuron spine membrane raft synapse protein heterodimerization activity protein N-terminus binding detection of temperature stimulus involved in sensory perception of pain negative regulation of release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol regulation of sensory perception of pain positive regulation of inositol phosphate biosynthetic process D-aspartate import inositol phosphate catabolic process positive regulation of arachidonic acid secretion positive regulation of inhibitory postsynaptic potential L-glutamate import across plasma membrane regulation of action potential positive regulation of cation channel activity uc008ojg.1 uc008ojg.2 uc008ojg.3 
ENSMUST00000029087.4 Ogfr ENSMUST00000029087.4 opioid growth factor receptor (from RefSeq NM_031373.3) A2ACT6 ENSMUST00000029087.1 ENSMUST00000029087.2 ENSMUST00000029087.3 NM_031373 OGFR_MOUSE Q99L33 Q99PG2 uc008ojj.1 uc008ojj.2 uc008ojj.3 uc008ojj.4 Receptor for opioid growth factor (OGF), also known as Met- enkephalin. Seems to be involved in growth regulation (By similarity). Cytoplasm Nucleus Note=The OGF/OGFR complex is probably translocated to the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99PG2-1; Sequence=Displayed; Name=2; IsoId=Q99PG2-2; Sequence=VSP_004061, VSP_004062; Expressed in all tissues examined, including brain, heart, lung, liver, kidney and skeletal muscle. Belongs to the opioid growth factor receptor family. opioid receptor activity nucleus cytoplasm membrane opioid receptor signaling pathway signaling receptor activity regulation of growth uc008ojj.1 uc008ojj.2 uc008ojj.3 uc008ojj.4 
ENSMUST00000029090.9 Gid8 ENSMUST00000029090.9 GID complex subunit 8, transcript variant 3 (from RefSeq NM_001289652.1) ENSMUST00000029090.1 ENSMUST00000029090.2 ENSMUST00000029090.3 ENSMUST00000029090.4 ENSMUST00000029090.5 ENSMUST00000029090.6 ENSMUST00000029090.7 ENSMUST00000029090.8 GID8_MOUSE NM_001289652 Q9D7M1 uc008ojy.1 uc008ojy.2 uc008ojy.3 uc008ojy.4 Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation. Homodimer; may also form higher oligomers (PubMed:27920276). Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8. Interacts with CTNNB1, AXIN1 and GSK3B (By similarity). Cytoplasm Nucleus Note=Localizes in the cytoplasm in the absence of Wnt stimulation and in the nucleus in the presence of Wnt stimulation. Ubiquitous. Polyubiquitinated through 'Lys-48'-polyubiquitin chains, leading to proteasomal degradation in the absence of Wnt stimulation. Belongs to the GID8 family. ubiquitin ligase complex nucleus nucleoplasm cytoplasm cytosol positive regulation of cell proliferation Wnt signaling pathway cell junction protein homodimerization activity positive regulation of canonical Wnt signaling pathway uc008ojy.1 uc008ojy.2 uc008ojy.3 uc008ojy.4 
ENSMUST00000029105.12 Zgpat ENSMUST00000029105.12 zinc finger, CCCH-type with G patch domain, transcript variant 1 (from RefSeq NM_144894.3) A2AU20 A2AU21 ENSMUST00000029105.1 ENSMUST00000029105.10 ENSMUST00000029105.11 ENSMUST00000029105.2 ENSMUST00000029105.3 ENSMUST00000029105.4 ENSMUST00000029105.5 ENSMUST00000029105.6 ENSMUST00000029105.7 ENSMUST00000029105.8 ENSMUST00000029105.9 Kiaa1847 NM_144894 Q3TW85 Q69Z90 Q8BWW2 Q8VDM1 ZGPAT_MOUSE uc008omb.1 uc008omb.2 uc008omb.3 Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity). Interacts with CHD4/Mi-2; the interaction is direct. Nucleus Sequence=BAD32554.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence=; Sequence=CAM26425.1; Type=Erroneous gene model prediction; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus plasma membrane negative regulation of epidermal growth factor-activated receptor activity sequence-specific DNA binding negative regulation of transcription, DNA-templated metal ion binding uc008omb.1 uc008omb.2 uc008omb.3 
ENSMUST00000029106.13 Zbtb46 ENSMUST00000029106.13 Functions as a transcriptional repressor for PRDM1. (from UniProt Q8BID6) A2AUD2 AK038975 Btbd4 ENSMUST00000029106.1 ENSMUST00000029106.10 ENSMUST00000029106.11 ENSMUST00000029106.12 ENSMUST00000029106.2 ENSMUST00000029106.3 ENSMUST00000029106.4 ENSMUST00000029106.5 ENSMUST00000029106.6 ENSMUST00000029106.7 ENSMUST00000029106.8 ENSMUST00000029106.9 Q3U2R2 Q8BID6 Q9D0G6 Q9D492 ZBT46_MOUSE uc290dnx.1 uc290dnx.2 Functions as a transcriptional repressor for PRDM1. Q8BID6; Q9CQT7: Desi1; NbExp=2; IntAct=EBI-7768990, EBI-7768710; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BID6-1; Sequence=Displayed; Name=2; IsoId=Q8BID6-2; Sequence=VSP_009387, VSP_009388; Sumoylated. Desumoylation by DESI1 reverses transcriptional repression activity. Sequence=BAB30386.1; Type=Erroneous initiation; Evidence=; Sequence=BAC30190.1; Type=Erroneous initiation; Evidence=; nucleic acid binding protein binding nucleus negative regulation of granulocyte differentiation negative regulation of macrophage differentiation negative regulation of monocyte differentiation metal ion binding negative regulation of dendritic cell differentiation positive regulation of dendritic cell differentiation uc290dnx.1 uc290dnx.2 
ENSMUST00000029116.14 Pcmtd2 ENSMUST00000029116.14 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2, transcript variant 1 (from RefSeq NM_153594.3) ENSMUST00000029116.1 ENSMUST00000029116.10 ENSMUST00000029116.11 ENSMUST00000029116.12 ENSMUST00000029116.13 ENSMUST00000029116.2 ENSMUST00000029116.3 ENSMUST00000029116.4 ENSMUST00000029116.5 ENSMUST00000029116.6 ENSMUST00000029116.7 ENSMUST00000029116.8 ENSMUST00000029116.9 NM_153594 PCMD2_MOUSE Q3UKB7 Q8BHD8 Q8BJT6 Q8BK38 Q8C0H6 Q8R1D5 uc008onu.1 uc008onu.2 uc008onu.3 uc008onu.4 May act as a substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May bind to the methyltransferase cofactor S- adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but probably does not display methyltransferase activity. Cytoplasm At its N-terminus, contains L-isoaspartate and S- adenosylmethionine (AdoMet) binding motifs. Also contains an extended SOCS box motif, where the Cul-box is separated from the BC-box by ~90 residues, within its C-terminus. Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family. Although the active site residue Ser is conserved, appears to lack catalytic activity in vitro. Sequence=BAC37785.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity cytoplasm cellular protein modification process protein methylation methylation uc008onu.1 uc008onu.2 uc008onu.3 uc008onu.4 
ENSMUST00000029125.10 Armc1 ENSMUST00000029125.10 armadillo repeat containing 1, transcript variant 1 (from RefSeq NM_028840.3) ARMC1_MOUSE ENSMUST00000029125.1 ENSMUST00000029125.2 ENSMUST00000029125.3 ENSMUST00000029125.4 ENSMUST00000029125.5 ENSMUST00000029125.6 ENSMUST00000029125.7 ENSMUST00000029125.8 ENSMUST00000029125.9 NM_028840 Q8CBW1 Q9D7A8 uc008oro.1 uc008oro.2 uc008oro.3 In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. Interacts with mitochondrial contact site and cristae organizing system (MICOS) complex components IMMT/MIC60 and MICOS10/MIC10 (By similarity). Interacts with mitochondrial outer membrane sorting assembly machinery (SAM) complex components SAMM50 and MTX1 (By similarity). Cytoplasm Mitochondrion Mitochondrion outer membrane Note=Associates with the outer mitochondrion membrane, most likely through its C-terminus (By similarity). Not integrated into the mitochondrial outer membrane (By similarity). mitochondrion biological_process metal ion transport metal ion binding uc008oro.1 uc008oro.2 uc008oro.3 
ENSMUST00000029126.15 Itch ENSMUST00000029126.15 itchy, E3 ubiquitin protein ligase, transcript variant 1 (from RefSeq NM_008395.3) ENSMUST00000029126.1 ENSMUST00000029126.10 ENSMUST00000029126.11 ENSMUST00000029126.12 ENSMUST00000029126.13 ENSMUST00000029126.14 ENSMUST00000029126.2 ENSMUST00000029126.3 ENSMUST00000029126.4 ENSMUST00000029126.5 ENSMUST00000029126.6 ENSMUST00000029126.7 ENSMUST00000029126.8 ENSMUST00000029126.9 ITCH_MOUSE NM_008395 O54971 Q8C863 uc008nke.1 uc008nke.2 uc008nke.3 uc008nke.4 Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:15358865, PubMed:16446428, PubMed:17592138, PubMed:18628966, PubMed:20392206, PubMed:25632008). It catalyzes 'Lys- 29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (By similarity). Involved in the control of inflammatory signaling pathways (By similarity). Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (By similarity). Promotes the association of the complex after TNF stimulation (By similarity). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (By similarity). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (By similarity). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2- dependent signal transduction pathways (By similarity). Regulates the transcriptional activity of several transcription factors involved in immune response (PubMed:15358865, PubMed:11828324). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (By similarity). Mediates JUN ubiquitination and degradation (PubMed:15358865). Mediates JUNB ubiquitination and degradation (PubMed:11828324, PubMed:15358865). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (PubMed:11828324). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (By similarity). Ubiquitinates MAVS through 'Lys- 48'-linked conjugation resulting in MAVS proteasomal degradation (By similarity). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (By similarity). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (By similarity). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (By similarity). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:18628966). Ubiquitinates SNX9 (By similarity). Ubiquitinates MAP3K7 through 'Lys- 48'-linked conjugation (PubMed:25632008). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (By similarity). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (By similarity). Ubiquitinates NEDD9/HEF1, resulting in proteasomal degradation of NEDD9/HEF1 (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence= Activated by NDFIP1- and NDFIP2-binding (PubMed:25632008). Activated by PI4K2A-binding (By similarity). Inhibited by DTX3L-binding (By similarity). Inhibited by N4BP1 binding (PubMed:17592138). Protein modification; protein ubiquitination. Monomer. Part of a ternary complex composed of SMAD3, ITCH/AIP4 and NEDD9/HEF1; within the complex NEDD9/HEF1 interacts (via N-terminus) with ITCH/AIP4 (via WW domains); the complex mediates ubiquitination and proteasomal degradation of NEDD9/HEF1 (By similarity). Interacts (via WW domains) with OCNL (PubMed:11782481). Interacts (via WW domains) with NOTCH1 (PubMed:10940313, PubMed:18628966). Interacts (via WW domains) JUN (PubMed:11828324). Interacts with JUNB; the interaction promotes ITCH-mediated ubiquitination and degradation of JUNB (PubMed:11828324). Interacts with FYN; the interaction phosphorylates ITCH on Tyr-381 decreasing binding of JUNB (By similarity). Interacts (via WW domain 2) with N4BP1; the interaction inhibits the E3 ubiquitin-protein ligase activity (PubMed:17592138). Interacts with NDFIP1 and NDFIP2; the interaction with NDFIP proteins activates the E3 ubiquitin-protein ligase and may induce its recruitment to exosomes (PubMed:11748237, PubMed:17137798, PubMed:25632008). Interacts with ARHGEF7 (By similarity). Interacts with RNF11 (By similarity). Interacts (via the WW 1 domain) with NFE2 (via the PXY motif 1); the interaction promotes 'Lys-63'-linked ubiquitination of NFE2, retains it in the cytoplasm and prevents its transactivation activity (By similarity). Interacts (via WW domains) with CXCR4 (via C-terminus); the interaction depends on CXCR4 phosphorylation (By similarity). Found in a complex with E3 ligase DTX3L and ESCRT-0 components HGS and STAM (By similarity). Interacts with DTX3L (via C-terminus); the interaction is increased upon CXCL12 stimulation and inhibits ITCH catalytic activity (the interaction is direct) (By similarity). Interacts with HGS (By similarity). Interacts (via WW domains) with PCBP2 within a complex containing ITCH, MAVS and PCBP2 (By similarity). Interacts (via WW domains) with TXNIP (via C-terminus) (By similarity). Interacts with p15 BID (PubMed:20392206). Interacts with ERBB4 (By similarity).Interacts with DTX1 (By similarity). Interacts with SPART (By similarity). Interacts with SNX9 and SNX18 (By similarity). Interacts (via its WW domains) with ATN1 (By similarity). Interacts (via WW domains) with SGK3 (By similarity). Interacts with CBLC (By similarity). Interacts with OTUD7B (By similarity). Interacts (via WW domain 1,2 and 3) with PI4K2A; the interaction inhibits PI4K2A catalytic activity and promotes ITCH catalytic activity (PubMed:23146885). Interacts with ARRDC4 (By similarity). Part of a complex containing ITCH, NDFIP1 and MAP3K7 (PubMed:25632008). Interacts with UBE2L3; the interaction is mediated by NDFIP1 (PubMed:25632008). Interacts with MAPK8/JNK1 (PubMed:16446428). Interacts (via WW domains) with ARRDC1 (via PPxY motifs); the interaction is direct and participates in the recruitment of the ubiquitin-protein ligase ITCH to the NOTCH1 receptor (By similarity). Interacts (via WW domains) with ARRDC2 (By similarity). Interacts (via WW domains) with ARRDC3 (By similarity). Interacts directly with LDLRAD3; this interaction promotes ITCH auto-ubiquitination leading to its degradation (PubMed:26854353). Interacts with ENTREP1; enhances the ubiquitination of CXCR4 by ITCH and its subsequent endocytosis (By similarity). (Microbial infection) Interacts with Epstein-Barr virus LMP2A. Q8C863; Q80TQ2: Cyld; NbExp=2; IntAct=EBI-851782, EBI-943859; Q8C863; O89091: Klf10; NbExp=4; IntAct=EBI-851782, EBI-10949150; Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm Nucleus Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Note=May be recruited to exosomes by NDFIP1. Localizes to plasma membrane upon CXCL12 stimulation where it co-localizes with CXCL4. Localization to early endosomes is increased upon CXCL12 stimulation where it co-localizes with DTX3L and CXCL4. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C863-1; Sequence=Displayed; Name=2; IsoId=Q8C863-2; Sequence=VSP_008452, VSP_008453; Detected in uterus (at protein level) (PubMed:23146885). Widely expressed (PubMed:9462742). The WW domains mediate interaction with PPxY motif-containing proteins. The WW domain 4 mediates interaction with ENTREP1. On T-cell activation, phosphorylation by the JNK cascade on serine and threonine residues surrounding the PRR domain accelerates the ubiquitination and degradation of JUN and JUNB. The increased ITCH catalytic activity due to phosphorylation by JNK1 may occur due to a conformational change disrupting the interaction between the PRR/WW motifs domain and the HECT domain and, thus exposing the HECT domain. Phosphorylation by FYN reduces interaction with JUNB and negatively controls JUN ubiquitination and degradation. Interacts directly with LDLRAD3; this interaction promotes ITCH auto-ubiquitination leading to its degradation (PubMed:26854353). Monoubiquitinated. Autopolyubiquitinated with 'Lys-63' linkages which does not lead to protein degradation. Note=Defects in Itch are the cause of the itchy phenotype which is an inflammatory and immunological condition characterized by inflammation in the lung and stomach, hyperplasia in lymphoid and hematopoietic cells and constant itching in the skin. [Isoform 1]: Major form. It is uncertain whether Met-1 or Met-11 is the initiator. Sequence=AAB99764.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ubiquitin ligase complex protein polyubiquitination immune system process positive regulation of T cell anergy ubiquitin-protein transferase activity protein binding nucleus nucleoplasm cytoplasm endosome cytosol plasma membrane cell cortex ubiquitin-dependent protein catabolic process apoptotic process endosome membrane membrane protein ubiquitination transferase activity ligase activity cytoplasmic vesicle early endosome membrane negative regulation of NF-kappaB transcription factor activity macromolecular complex protein K29-linked ubiquitination ribonucleoprotein complex binding negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process intracellular membrane-bounded organelle ubiquitin-like protein ligase binding innate immune response CXCR chemokine receptor binding positive regulation of protein catabolic process negative regulation of JNK cascade negative regulation of alpha-beta T cell proliferation negative regulation of defense response to virus defense response to virus protein autoubiquitination ubiquitin protein ligase activity protein K63-linked ubiquitination protein K48-linked ubiquitination regulation of protein deubiquitination arrestin family protein binding positive regulation of receptor catabolic process early endosome uc008nke.1 uc008nke.2 uc008nke.3 uc008nke.4 
ENSMUST00000029128.4 Map1lc3a ENSMUST00000029128.4 microtubule-associated protein 1 light chain 3 alpha, transcript variant 1 (from RefSeq NM_025735.3) A2AVS1 ENSMUST00000029128.1 ENSMUST00000029128.2 ENSMUST00000029128.3 MLP3A_MOUSE NM_025735 Q91VR7 Q9DC74 uc012cha.1 uc012cha.2 uc012cha.3 uc012cha.4 Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with TP53INP1 and TP53INP2 (By similarity). Directly interacts with SQSTM1; this interaction leads to MAP1LC3A recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy (By similarity). Interacts with ATG13 (By similarity). Interacts with ULK1 (By similarity). Interacts with TBC1D5 (By similarity). Found in a complex with UBQLN1 and UBQLN2 (By similarity). Interacts with UBQLN4 (via STI1 1 and 2 domains) (By similarity). Interacts with UBQLN1 in the presence of UBQLN4 (By similarity). Interacts with TRIM5 (By similarity). Interacts with MEFV (By similarity). Interacts with reticulophagy regulators RETREG1, RETREG2 and RETREG3 (PubMed:34338405). Interacts with PICALM (By similarity). Interacts with the reticulophagy receptor TEX264 (By similarity). Interacts with MOAP1 (via LIR motif) (By similarity). Interacts with Irgm1 (By similarity). Q91VR7; Q811T9: Disc1; NbExp=2; IntAct=EBI-2933755, EBI-2298259; Endomembrane system ; Lipid-anchor Cytoplasmic vesicle, autophagosome membrane ; Lipid-anchor Cytoplasmic vesicle, autophagosome Cytoplasm, cytoskeleton Note=LC3-II binds to the autophagic membranes. The precursor molecule is cleaved by ATG4 (ATG4A, ATG4B, ATG4C or ATG4D) to expose the glycine at the C-terminus and form the cytosolic form, LC3-I (PubMed:12207896, PubMed:14530254). The processed form is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, LC3-II (By similarity). During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid (By similarity). ATG4 proteins also mediate the delipidation of PE- conjugated forms (PubMed:33795848). In addition, ATG4B and ATG4D mediate delipidation of ATG8 proteins conjugated to PS during non- canonical autophagy (By similarity). ATG4B constitutes the major protein for proteolytic activation (By similarity). ATG4D is the main enzyme for delipidation activity (PubMed:33795848). Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). Belongs to the ATG8 family. autophagosome assembly autophagosome membrane mitophagy protein binding phospholipid binding cytoplasm late endosome autophagosome cytosol cytoskeleton microtubule autophagy cellular response to nitrogen starvation microtubule binding phosphatidylethanolamine binding cellular response to starvation response to iron(II) ion response to lead ion endomembrane system microtubule cytoskeleton membrane macroautophagy organelle membrane cytoplasmic vesicle ubiquitin protein ligase binding response to nutrient levels cellular response to amino acid starvation response to morphine autolysosome synapse cellular response to hydrogen peroxide cellular response to copper ion autophagosome maturation uc012cha.1 uc012cha.2 uc012cha.3 uc012cha.4 
ENSMUST00000029131.11 Ggt7 ENSMUST00000029131.11 gamma-glutamyltransferase 7, transcript variant 2 (from RefSeq NM_144786.2) A2AQN1 ENSMUST00000029131.1 ENSMUST00000029131.10 ENSMUST00000029131.2 ENSMUST00000029131.3 ENSMUST00000029131.4 ENSMUST00000029131.5 ENSMUST00000029131.6 ENSMUST00000029131.7 ENSMUST00000029131.8 ENSMUST00000029131.9 GGT7_MOUSE Ggt7 Ggtl3 NM_144786 Q91V91 Q99JP7 uc012chc.1 uc012chc.2 uc012chc.3 Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors. Reaction=an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]; Xref=Rhea:RHEA:23904, Rhea:RHEA-COMP:9780, Rhea:RHEA-COMP:9795, ChEBI:CHEBI:77644, ChEBI:CHEBI:78597, ChEBI:CHEBI:78599, ChEBI:CHEBI:78608; EC=2.3.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23905; Evidence=; Reaction=glutathione + H2O = L-cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:28807, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:57925, ChEBI:CHEBI:61694; EC=3.4.19.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28808; Evidence=; Reaction=an S-substituted glutathione + H2O = an S-substituted L- cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:59468, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:90779, ChEBI:CHEBI:143103; EC=3.4.19.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59469; Evidence=; Sulfur metabolism; glutathione metabolism. Heterodimer composed of the light and heavy chains. The active site is located in the light chain. Membrane ; Single- pass type II membrane protein Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme. Belongs to the gamma-glutamyltransferase family. peptidyltransferase activity plasma membrane translation proteolysis glutathione metabolic process glutathione biosynthetic process glutathione catabolic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups hydrolase activity glutathione hydrolase activity negative regulation of response to oxidative stress uc012chc.1 uc012chc.2 uc012chc.3 
ENSMUST00000029132.11 Dnajc5b ENSMUST00000029132.11 DnaJ heat shock protein family (Hsp40) member C5 beta, transcript variant 2 (from RefSeq NM_025489.3) Cspbeta DNJ5B_MOUSE ENSMUST00000029132.1 ENSMUST00000029132.10 ENSMUST00000029132.2 ENSMUST00000029132.3 ENSMUST00000029132.4 ENSMUST00000029132.5 ENSMUST00000029132.6 ENSMUST00000029132.7 ENSMUST00000029132.8 ENSMUST00000029132.9 NM_025489 Q810R9 Q9CQ94 uc008orv.1 uc008orv.2 uc008orv.3 uc008orv.4 Interacts with the chaperone complex consisting of HSC70 and SGTA. Membrane ; Lipid-anchor Palmitoylated. cellular_component biological_process membrane uc008orv.1 uc008orv.2 uc008orv.3 uc008orv.4 
ENSMUST00000029135.15 Acss2 ENSMUST00000029135.15 acyl-CoA synthetase short-chain family member 2 (from RefSeq NM_019811.3) ACSA_MOUSE Acas2 Acecs1 ENSMUST00000029135.1 ENSMUST00000029135.10 ENSMUST00000029135.11 ENSMUST00000029135.12 ENSMUST00000029135.13 ENSMUST00000029135.14 ENSMUST00000029135.2 ENSMUST00000029135.3 ENSMUST00000029135.4 ENSMUST00000029135.5 ENSMUST00000029135.6 ENSMUST00000029135.7 ENSMUST00000029135.8 ENSMUST00000029135.9 NM_019811 Q8BK97 Q9QXG4 uc008nku.1 uc008nku.2 uc008nku.3 Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:11150295, PubMed:16790548, PubMed:28562591). Acetate is the preferred substrate but can also utilize propionate with a much lower affinity (PubMed:11150295). Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis (By similarity). Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription (By similarity). The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival (By similarity). Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (PubMed:28562591). Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long- term spatial memory (PubMed:28562591). Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:456215; EC=6.2.1.1; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23177; Evidence=; Reaction=ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA; Xref=Rhea:RHEA:20373, ChEBI:CHEBI:17272, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392, ChEBI:CHEBI:456215; EC=6.2.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20374; Evidence=; Inhibited by acetylation at Lys-661 and activated by deacetylation mediated by the deacetylases SIRT1 and SIRT3. Kinetic parameters: KM=0.11 mM for acetate ; KM=3.4 mM for propionate ; Monomer (By similarity). Interacts with TFEB (By similarity). AMPK-mediated phosphorylated form at Ser-659 interacts with KPNA1; this interaction results in nuclear translocation of ACSS2 (By similarity). Interacts with the 'Thr-172' phosphorylated form of PRKAA2 (By similarity). Interacts with CREBBP (PubMed:28562591). Cytoplasm, cytosol toplasm Nucleus Note=Glucose deprivation results in its AMPK-dependent phosphorylation and subsequent nuclear translocation. Phosphorylation at Ser-659, leads to exposure of its nuclear localization signal which is required for its interaction with KPNA1 and subsequent translocation to the nucleus (By similarity). Found in the cytoplasm in undifferentiated neurons and upon differentiation, translocates to nucleus (PubMed:28562591). Expressed in the hippocampus. Reversibly acetylated at Lys-661 (PubMed:16790548). The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylases SIRT1 and SIRT3. Knockdown in the hippocampus decreases histone acetylation and is accompanied by impaired object location memory and defective up-regulation of immediate early genes following training. Belongs to the ATP-dependent AMP-binding enzyme family. nucleotide binding catalytic activity acetate-CoA ligase activity ATP binding nucleoplasm cytoplasm cytosol acetyl-CoA biosynthetic process lipid biosynthetic process ligase activity acetate biosynthetic process propionate biosynthetic process intracellular membrane-bounded organelle propionate-CoA ligase activity uc008nku.1 uc008nku.2 uc008nku.3 
ENSMUST00000029139.9 Trim55 ENSMUST00000029139.9 tripartite motif-containing 55 (from RefSeq NM_001081281.2) ENSMUST00000029139.1 ENSMUST00000029139.2 ENSMUST00000029139.3 ENSMUST00000029139.4 ENSMUST00000029139.5 ENSMUST00000029139.6 ENSMUST00000029139.7 ENSMUST00000029139.8 G3X8Y1 G3X8Y1_MOUSE NM_001081281 Trim55 uc008orw.1 uc008orw.2 uc008orw.3 zinc ion binding identical protein binding metal ion binding uc008orw.1 uc008orw.2 uc008orw.3 
ENSMUST00000029140.12 Procr ENSMUST00000029140.12 protein C receptor, endothelial, transcript variant 1 (from RefSeq NM_011171.3) ENSMUST00000029140.1 ENSMUST00000029140.10 ENSMUST00000029140.11 ENSMUST00000029140.2 ENSMUST00000029140.3 ENSMUST00000029140.4 ENSMUST00000029140.5 ENSMUST00000029140.6 ENSMUST00000029140.7 ENSMUST00000029140.8 ENSMUST00000029140.9 EPCR_MOUSE Epcr NM_011171 Q4FK76 Q64695 Q9WV33 uc008nlh.1 uc008nlh.2 uc008nlh.3 uc008nlh.4 Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. Membrane; Single-pass type I membrane protein. Expressed in endothelial cells. extracellular space centrosome blood coagulation hemostasis protein C-terminus binding membrane integral component of membrane signaling receptor activity perinuclear region of cytoplasm negative regulation of coagulation uc008nlh.1 uc008nlh.2 uc008nlh.3 uc008nlh.4 
ENSMUST00000029141.6 Mmp24 ENSMUST00000029141.6 matrix metallopeptidase 24 (from RefSeq NM_010808.4) A2AUV7 ENSMUST00000029141.1 ENSMUST00000029141.2 ENSMUST00000029141.3 ENSMUST00000029141.4 ENSMUST00000029141.5 MMP24_MOUSE Mmp21 Mt5mmp NM_010808 Q9R0S2 Q9Z0J9 uc008nlj.1 uc008nlj.2 uc008nlj.3 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein do not develop neuropathic pain with mechanical allodynia after sciatic nerve injury, display enhanced sensitivity to noxious thermal stimuli under basal conditions, and develop hyperalgesia during inflammation. [provided by RefSeq, Feb 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB021226.1, AJ010262.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence (PubMed:19805319, PubMed:24952463). Involved in cell- cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia (PubMed:19805319). Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence (PubMed:24952463). May play a role in axonal growth (PubMed:11714638). Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (PubMed:10622708). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with GRIP1 and GRIP2 (By similarity). Interacts (via PDZ-binding motif) with APBA3 (via PDZ domain). [Matrix metalloproteinase-24]: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. [Processed matrix metalloproteinase-24]: Secreted, extracellular space, extracellular matrix. Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage. Mainly expressed in neuronal cells of both central and peripheral nervous systems. Expressed by CGRP-containing peptidergic nociceptors in dorsal root ganglia (PubMed:19805319). Expressed in adult neural stem cell and ependymocytes (PubMed:24952463). Expressed at low level in testis. Expressed at day 11 until day 15, before dropping around day 17 before birth. Expressed in the cerebrum in embryos, but it declines after birth, while expression in the cerebellum starts to increase postnatally and continues thereafter. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The PDZ-binding motif (also named EWV motif) is required for interaction with PDZ domains of APBA3 and recycling through the trans- Golgi network. Cleaved by a furin endopeptidase in the trans-Golgi network. No visible phenotype. Mice are viable, develop normally and are fertile. They however display enhanced sensitivity to noxious thermal stimuli under basal conditions characterized by an absence of thermal inflammatory hyperalgesia (PubMed:19805319). In subependymal zone, more intense signal is observed for extracellular N- cadherin (Cdh2) as well as increased levels of full-length Cdh2 without changes in Cdh2 messenger RNA levels (PubMed:24952463). Belongs to the peptidase M10A family. metalloendopeptidase activity extracellular region extracellular space Golgi apparatus plasma membrane integral component of plasma membrane proteolysis cell adhesion peptidase activity metallopeptidase activity zinc ion binding glial cell differentiation membrane integral component of membrane hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix trans-Golgi network membrane cell-cell adhesion mediated by cadherin cadherin binding metal ion binding detection of temperature stimulus involved in sensory perception of pain neuronal stem cell population maintenance cell-cell adhesion via plasma-membrane adhesion molecules uc008nlj.1 uc008nlj.2 uc008nlj.3 
ENSMUST00000029142.15 Eif6 ENSMUST00000029142.15 eukaryotic translation initiation factor 6 (from RefSeq NM_010579.2) EIF6 ENSMUST00000029142.1 ENSMUST00000029142.10 ENSMUST00000029142.11 ENSMUST00000029142.12 ENSMUST00000029142.13 ENSMUST00000029142.14 ENSMUST00000029142.2 ENSMUST00000029142.3 ENSMUST00000029142.4 ENSMUST00000029142.5 ENSMUST00000029142.6 ENSMUST00000029142.7 ENSMUST00000029142.8 ENSMUST00000029142.9 Eif6 ITGB4BP Itgb4bp NM_010579 Q545K4 Q545K4_MOUSE uc008nll.1 uc008nll.2 uc008nll.3 The protein encoded by this gene is a eukaryotic translation initiation factor that regulates both ribosome biogenesis and translation, which are rate-limiting factors for cell growth. The encoded protein binds 60S ribosomes and prevents their association with 40S ribosomes. This gene may play a role in oncogenesis as well. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015274.1, AF108462.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS- dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth. Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC). Cytoplasm Nucleus, nucleolus Note=Shuttles between cytoplasm and nucleus/nucleolus. Phosphorylation at Ser-174 and Ser-175 promotes nuclear export. Belongs to the eIF-6 family. ribosomal subunit export from nucleus translation initiation factor activity nucleus nucleoplasm nucleolus cytoplasm translation translational initiation gene silencing by miRNA miRNA mediated inhibition of translation ribosome biogenesis mature ribosome assembly ribosomal large subunit biogenesis ribosome binding ribosomal large subunit binding uc008nll.1 uc008nll.2 uc008nll.3 
ENSMUST00000029143.7 Fam83c ENSMUST00000029143.7 family with sequence similarity 83, member C (from RefSeq NM_027788.3) A0A6Q6PLP7 A0A6Q6PLP7_MOUSE ENSMUST00000029143.1 ENSMUST00000029143.2 ENSMUST00000029143.3 ENSMUST00000029143.4 ENSMUST00000029143.5 ENSMUST00000029143.6 Fam83c NM_027788 uc008nlm.1 uc008nlm.2 uc008nlm.3 uc008nlm.4 Belongs to the FAM83 family. uc008nlm.1 uc008nlm.2 uc008nlm.3 uc008nlm.4 
ENSMUST00000029147.16 Nfs1 ENSMUST00000029147.16 nitrogen fixation gene 1 (S. cerevisiae), transcript variant 5 (from RefSeq NR_185175.1) ENSMUST00000029147.1 ENSMUST00000029147.10 ENSMUST00000029147.11 ENSMUST00000029147.12 ENSMUST00000029147.13 ENSMUST00000029147.14 ENSMUST00000029147.15 ENSMUST00000029147.2 ENSMUST00000029147.3 ENSMUST00000029147.4 ENSMUST00000029147.5 ENSMUST00000029147.6 ENSMUST00000029147.7 ENSMUST00000029147.8 ENSMUST00000029147.9 NFS1_MOUSE NR_185175 Nfs1 Nifs Q8C6I5 Q9Z1J3 uc008nmj.1 uc008nmj.2 uc008nmj.3 uc008nmj.4 Mitochondrial cysteine desulfurase, of the core iron-sulfur cluster (ISC) assembly complex, that catalyzes the desulfuration of L- cysteine to L-alanine, as component of the cysteine desulfurase complex, leading to the formation of a cysteine persulfide intermediate at the active site cysteine residue and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:25597503). The persulfide is then transferred on the flexible Cys loop from the catalytic site of NFS1 to the surface of NFS1 (By similarity). After the NFS1-linked persulfide sulfur is transferred to one of the conserved Cys residues of the scaffold, a reaction assisted by FXN (PubMed:25597503). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). Reaction=[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L- alanine; Xref=Rhea:RHEA:43892, Rhea:RHEA-COMP:14737, Rhea:RHEA- COMP:14739, ChEBI:CHEBI:29917, ChEBI:CHEBI:35235, ChEBI:CHEBI:57972, ChEBI:CHEBI:64428; EC=2.8.1.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43893; Evidence=; Reaction=[sulfur-carrier protein]-L-cysteine + L-cysteine = [sulfur- carrier protein]-S-sulfanyl-L-cysteine + L-alanine; Xref=Rhea:RHEA:17457, Rhea:RHEA-COMP:10742, Rhea:RHEA-COMP:10744, ChEBI:CHEBI:29950, ChEBI:CHEBI:35235, ChEBI:CHEBI:57972, ChEBI:CHEBI:61963; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Active only in complex with LYRM4. Homodimer (By similarity). Component of the mitochondrial core iron-sulfur cluster (ISC) complex composed of NFS1, LYRM4, NDUFAB1, ISCU, FXN, and FDX2; this complex is an heterohexamer containing two copies of each monomer (By similarity). Component of cyteine desulfurase complex composed of NFS1, LYRM4 and NDUFAB1; this complex contributes to the activation of cysteine desulfurase activity and NFS1 stabilization. Interacts (homodimer form) with ISCU (D-state); each monomer interacts with the C-terminal regions of each NFS1 monomer. Interacts with HSPA9. Interacts (via homodimer form) with FDX2. Interacts (via homodimer form) with FXN. Interacts with LYRM4 (By similarity). Component of a complex composed of FXN, NFS1, LYRM4 and ISCU (PubMed:21298097, PubMed:25597503). Mitochondrion Ubiquitous. N-gluconoylated. Cysteine persulfide intermediate is reduced by thiol-containing molecules like glutathione and L-cysteine (PubMed:25597503). Persulfide reduction is a rate-limiting step of cysteine desulfurase catalytic cycle (PubMed:25597503). Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. catalytic activity nucleus nucleoplasm cytoplasm mitochondrion mitochondrial matrix cytosol Mo-molybdopterin cofactor biosynthetic process iron-sulfur cluster assembly transferase activity iron incorporation into metallo-sulfur cluster pyridoxal phosphate binding cysteine desulfurase activity protein homodimerization activity [2Fe-2S] cluster assembly metal ion binding iron-sulfur cluster binding uc008nmj.1 uc008nmj.2 uc008nmj.3 uc008nmj.4 
ENSMUST00000029149.13 Rbm39 ENSMUST00000029149.13 RNA binding motif protein 39, transcript variant 5 (from RefSeq NM_001362764.1) Caper ENSMUST00000029149.1 ENSMUST00000029149.10 ENSMUST00000029149.11 ENSMUST00000029149.12 ENSMUST00000029149.2 ENSMUST00000029149.3 ENSMUST00000029149.4 ENSMUST00000029149.5 ENSMUST00000029149.6 ENSMUST00000029149.7 ENSMUST00000029149.8 ENSMUST00000029149.9 NM_001362764 Q5RJI0 Q8VH51 Q99KV0 RBM39_MOUSE Rnpc2 uc008nms.1 uc008nms.2 uc008nms.3 uc008nms.4 uc008nms.5 uc008nms.6 RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing (By similarity). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (PubMed:11704680). Interacts with NCOA6 and JUN (PubMed:11704680). Interacts with ESR1 and ESR2, in the presence of estradiol (E2) (PubMed:11704680). Interacts with RSRC1 (via Arg/Ser-rich domain) (By similarity). Interacts with SF3B1 (By similarity). Interacts with ZNF106 (via N- terminus) (PubMed:27418600). Nucleus Event=Alternative splicing; Named isoforms=3; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=HCC1.4; IsoId=Q8VH51-1; Sequence=Displayed; Name=2; Synonyms=HCC1.3; IsoId=Q8VH51-2; Sequence=VSP_005822; Name=3; IsoId=Q8VH51-3; Sequence=VSP_005821, VSP_005822; Belongs to the splicing factor SR family. nucleic acid binding transcription coactivator activity RNA binding protein binding nucleus nucleoplasm microtubule organizing center transcription, DNA-templated mRNA processing RNA splicing microtubule cytoskeleton nuclear speck macromolecular complex positive regulation of nucleic acid-templated transcription uc008nms.1 uc008nms.2 uc008nms.3 uc008nms.4 uc008nms.5 uc008nms.6 
ENSMUST00000029158.4 Aar2 ENSMUST00000029158.4 AAR2 splicing factor homolog, transcript variant 2 (from RefSeq NM_026661.4) AAR2_MOUSE ENSMUST00000029158.1 ENSMUST00000029158.2 ENSMUST00000029158.3 NM_026661 Q3TEN8 Q3TM16 Q8VBU9 Q9D2V5 uc008nnp.1 uc008nnp.2 uc008nnp.3 uc008nnp.4 Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Interacts with PRPF8 (via RNase H homology domain) (By similarity). Component of a U5 snRNP complex that contains PRPF8 (By similarity). Belongs to the AAR2 family. spliceosomal tri-snRNP complex assembly molecular_function cellular_component spliceosomal complex mRNA processing RNA splicing uc008nnp.1 uc008nnp.2 uc008nnp.3 uc008nnp.4 
ENSMUST00000029164.9 Sla2 ENSMUST00000029164.9 Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. (from UniProt Q8R4L0) AK030877 ENSMUST00000029164.1 ENSMUST00000029164.2 ENSMUST00000029164.3 ENSMUST00000029164.4 ENSMUST00000029164.5 ENSMUST00000029164.6 ENSMUST00000029164.7 ENSMUST00000029164.8 Q3UU74 Q8C0K2 Q8R4L0 Q8VI42 Q9D1Z9 SLAP2_MOUSE uc008nod.1 uc008nod.2 uc008nod.3 Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Interacts (via its C-terminal domain) with CBL (phosphorylated). Interacts (via SH2 domain) with ZAP70 (phosphorylated) and CD3Z (phosphorylated). Interacts (via SH2 domain) with CSF1R (phosphorylated). Q8R4L0; P36888: FLT3; Xeno; NbExp=14; IntAct=EBI-20766300, EBI-3946257; Cytoplasm. Cell membrane. Cytoplasmic vesicle. Late endosome. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles. Event=Alternative initiation; Named isoforms=2; Name=1; Synonyms=p28; IsoId=Q8R4L0-1; Sequence=Displayed; Name=2; Synonyms=p25; IsoId=Q8R4L0-2; Sequence=VSP_018795; Mainly expressed in immune system. Highly expressed in spleen and thymus and expressed at intermediate levels in lung. Not expressed in liver, heart and brain. Isoform 1 is predominant in lung and spleen, while isoform 2 is predominant in thymus. The loss of the C-terminal domain partially abolishes the inhibitory function. Phosphorylated by CSF1R. PubMed:12024036 confirmed the alternative initiation by mutating the Met in position 1 to Val, and showed that isoform 1 is abolished in favor of isoform 2. Sequence=BAB32223.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter adaptive immune response immune system process SH3/SH2 adaptor activity protein binding nucleoplasm cytoplasm endosome late endosome Golgi apparatus plasma membrane phosphatidylinositol 3-kinase complex regulation of signal transduction positive regulation of signal transduction membrane cytoplasmic vesicle T cell activation intracellular membrane-bounded organelle regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity protein N-terminus binding negative regulation of calcium-mediated signaling uc008nod.1 uc008nod.2 uc008nod.3 
ENSMUST00000029165.4 Rab5if ENSMUST00000029165.4 RAB5 interacting factor (from RefSeq NM_026124.3) ENSMUST00000029165.1 ENSMUST00000029165.2 ENSMUST00000029165.3 NM_026124 Q9CQT9 RCAF1_MOUSE Rab5if Rcaf1 uc008noc.1 uc008noc.2 uc008noc.3 uc008noc.4 uc008noc.5 Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (By similarity). In addition to its role in multi-pass membrane insertion, RAB5IF/OPTI also acts as an assembly factor for mitochondrial respiratory complexes (PubMed:31536960). Component of the GET- and EMC-like (GEL) complex, composed of RAB5IF/OPTI and TMCO1 (By similarity). The GEL complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47) (By similarity). The MPT complex associates with the SEC61 complex (By similarity). Interacts with NDUFS3, NDUFA4, NDUFV1, NDUFA9 and NDUFS8 of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:31536960). Interacts with UQCRC2 of the ubiquinol-cytochrome c reductase complex (Complex III) (PubMed:31536960). Interacts with COX5A and COX7C of the cytochrome c oxidase complex (Complex IV) (PubMed:31536960). Endoplasmic reticulum membrane ; Multi-pass membrane protein Mitochondrion inner membrane ; Multi-pass membrane protein Expressed in neuronal cells. Belongs to the EMC6 family. molecular_function mitochondrion biological_process uc008noc.1 uc008noc.2 uc008noc.3 uc008noc.4 uc008noc.5 
ENSMUST00000029170.8 Rbl1 ENSMUST00000029170.8 RB transcriptional corepressor like 1, transcript variant 1 (from RefSeq NM_011249.2) ENSMUST00000029170.1 ENSMUST00000029170.2 ENSMUST00000029170.3 ENSMUST00000029170.4 ENSMUST00000029170.5 ENSMUST00000029170.6 ENSMUST00000029170.7 NM_011249 Q3U1D4 Q64701 RBL1_MOUSE uc008noq.1 uc008noq.2 uc008noq.3 uc008noq.4 uc008noq.5 Key regulator of entry into cell division (By similarity). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (PubMed:15750587). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (PubMed:15750587). Controls histone H4 'Lys-20' trimethylation (PubMed:15750587). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (PubMed:15750587). Potent inhibitor of E2F- mediated trans-activation (By similarity). May act as a tumor suppressor (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2 (By similarity). The complex exists in quiescent cells where it represses cell cycle-dependent genes (By similarity). It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (By similarity). Interacts with AATF (By similarity). Interacts with KDM5A (By similarity). Interacts with KMT5B and KMT5C (PubMed:11571651). Interacts with USP4 (PubMed:15750587). Interacts with RBBP9 (By similarity). Q64701; Q155P7: Cenpf; NbExp=3; IntAct=EBI-1213109, EBI-2211248; Nucleus Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q64701-1; Sequence=Displayed; Name=Short; IsoId=Q64701-2; Sequence=VSP_005537, VSP_005538; Highly expressed in fetal heart and liver. Expressed at low levels in all other fetal tissues except skeletal muscle. High levels in neonatal spleen and thymus with low levels in other tissues. In adult, highly expressed in testis. Barely detectable in other tissues. Highly expressed in fetal tissues. Expression markedly decreased in adult. Cell-cycle arrest properties are inactivated by phosphorylation on Thr-332, Ser-640, Ser-959 and Ser-970 by CDK4. Belongs to the retinoblastoma protein (RB) family. negative regulation of transcription from RNA polymerase II promoter chromatin RNA polymerase II regulatory region DNA binding RNA polymerase II activating transcription factor binding protein binding nucleus nucleoplasm transcription factor complex chromatin organization regulation of transcription from RNA polymerase II promoter cell cycle regulation of mitotic cell cycle transcription factor binding negative regulation of gene expression cell differentiation regulation of lipid kinase activity regulation of cell division regulation of cell cycle promoter-specific chromatin binding negative regulation of G1/S transition of mitotic cell cycle negative regulation of cellular senescence uc008noq.1 uc008noq.2 uc008noq.3 uc008noq.4 uc008noq.5 
ENSMUST00000029172.2 Ghrh ENSMUST00000029172.2 growth hormone releasing hormone, transcript variant 1 (from RefSeq NM_010285.3) ENSMUST00000029172.1 Ghrh NM_010285 Q544X5 Q544X5_MOUSE uc008noy.1 uc008noy.2 uc008noy.3 This gene encodes a hormone that has stimulatory effects on pituitary growth hormone synthesis and release, and somatotrope expansion. The encoded preproprotein undergoes proteolytic processing to generate the mature peptide that is secreted by hypothalamus. Mice lacking the encoded protein are deficient in the growth hormone, live longer and exhibit growth retardation, enhanced insulin sensitivity and increased xenobiotic metabolism. [provided by RefSeq, Jul 2016]. GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. Secreted Belongs to the glucagon family. hormone activity extracellular region adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cell proliferation growth hormone-releasing hormone activity growth hormone secretion growth hormone-releasing hormone receptor binding positive regulation of multicellular organism growth positive regulation of growth hormone secretion uc008noy.1 uc008noy.2 uc008noy.3 
ENSMUST00000029178.7 Ctnnbl1 ENSMUST00000029178.7 catenin, beta like 1 (from RefSeq NM_025680.4) CTBL1_MOUSE ENSMUST00000029178.1 ENSMUST00000029178.2 ENSMUST00000029178.3 ENSMUST00000029178.4 ENSMUST00000029178.5 ENSMUST00000029178.6 NM_025680 Q3UL41 Q80X64 Q8VHE3 Q9CWL8 uc008nph.1 uc008nph.2 uc008nph.3 uc008nph.4 Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity). Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies (PubMed:20585033). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2 (By similarity). Nucleus The surface residues of the concave side of the superhelical ARM repeat region contribute to, but are not essential for NLS binding. Prp19 complex protein binding nucleus nucleoplasm spliceosomal complex apoptotic process somatic diversification of immunoglobulins enzyme binding positive regulation of apoptotic process uc008nph.1 uc008nph.2 uc008nph.3 uc008nph.4 
ENSMUST00000029179.11 Tti1 ENSMUST00000029179.11 TELO2 interacting protein 1 (from RefSeq NM_029282.2) ENSMUST00000029179.1 ENSMUST00000029179.10 ENSMUST00000029179.2 ENSMUST00000029179.3 ENSMUST00000029179.4 ENSMUST00000029179.5 ENSMUST00000029179.6 ENSMUST00000029179.7 ENSMUST00000029179.8 ENSMUST00000029179.9 NM_029282 Q7TS79 Q91V83 Q9CSY0 TTI1_MOUSE uc008npk.1 uc008npk.2 Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals (By similarity). Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with ATM, ATR, MTOR, PRKDC, SMG1, TELO2, TRRAP and TTI2. Component of the mTORC1 and mTORC2 complexes. Interacts with WAC; WAC positively regulates MTOR activity by promoting the assembly of the TTT complex and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex which leads to the dimerization of the mTORC1 complex and its subsequent activation. Cytoplasm Phosphorylated at Ser-823 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by the SCF(FBXO9) complex. Phosphorylation by CK2 only takes place when TELO2 is bound to mTORC1, not mTORC2; leading to selective ubiquitination of mTORC1- associated protein (By similarity). Ubiquitinated by the SCF(FBXO9) complex following phosphorylation by CK2 in response to growth factor deprivation, leading to its degradation by the proteasome. Only mTORC1-associated protein is ubiquitinated and degraded, leading to selective inactivation of mTORC1 to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity). Belongs to the tti1 family. molecular_function cytoplasm TORC1 complex TORC2 complex regulation of TOR signaling ASTRA complex uc008npk.1 uc008npk.2 
ENSMUST00000029183.3 Fam83d ENSMUST00000029183.3 family with sequence similarity 83, member D, transcript variant 3 (from RefSeq NR_184811.1) A2AC91 ENSMUST00000029183.1 ENSMUST00000029183.2 FA83D_MOUSE Fam83d NR_184811 Q3TXE0 Q6P396 Q8BYC0 Q9D7I8 uc008nqq.1 uc008nqq.2 uc008nqq.3 uc008nqq.4 Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (By similarity). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (By similarity). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (By similarity). Interacts with FBXW7; promotes FBXW7 degradation (By similarity). May interact with RAF1 (By similarity). Interacts with KIF22; recruits KIF22 to mitotic spindle microtubules (By similarity). Interacts (via C-terminus) with DYNLL1 (By similarity). Interacts with HMMR (By similarity). Interacts (via N-terminus) with CSNK1A1/CK1a; in mitotic cells (By similarity). Cytoplasm Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=Primarily cytoplasmic during interphase, but at prophase, associates with spindle microtubules, with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and anaphase. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D7I8-1; Sequence=Displayed; Name=2; IsoId=Q9D7I8-2; Sequence=VSP_036447; Name=3; IsoId=Q9D7I8-3; Sequence=VSP_039768; Phosphorylated during mitosis. Belongs to the FAM83 family. spindle pole epithelial to mesenchymal transition cytoplasm spindle cytoskeleton cell cycle microtubule binding cell proliferation cell migration kinesin binding protein kinase binding regulation of TOR signaling regulation of protein catabolic process cell division metaphase plate congression regulation of ERK1 and ERK2 cascade mitotic spindle pole protein localization to mitotic spindle positive regulation of cell cycle G1/S phase transition uc008nqq.1 uc008nqq.2 uc008nqq.3 uc008nqq.4 
ENSMUST00000029188.8 Ccn5 ENSMUST00000029188.8 cellular communication network factor 5 (from RefSeq NM_016873.2) A2AHD1 A2AHD1_MOUSE Ccn5 ENSMUST00000029188.1 ENSMUST00000029188.2 ENSMUST00000029188.3 ENSMUST00000029188.4 ENSMUST00000029188.5 ENSMUST00000029188.6 ENSMUST00000029188.7 NM_016873 Wisp2 uc008ntm.1 uc008ntm.2 uc008ntm.3 uc008ntm.4 uc008ntm.5 Secreted Belongs to the CCN family. insulin-like growth factor binding extracellular region extracellular space nucleus uc008ntm.1 uc008ntm.2 uc008ntm.3 uc008ntm.4 uc008ntm.5 
ENSMUST00000029194.12 Skil ENSMUST00000029194.12 SKI-like, transcript variant 1 (from RefSeq NM_011386.4) ENSMUST00000029194.1 ENSMUST00000029194.10 ENSMUST00000029194.11 ENSMUST00000029194.2 ENSMUST00000029194.3 ENSMUST00000029194.4 ENSMUST00000029194.5 ENSMUST00000029194.6 ENSMUST00000029194.7 ENSMUST00000029194.8 ENSMUST00000029194.9 NM_011386 Q60665 Q60702 Q78E90 Q80VK5 SKIL_MOUSE Skir Sno uc008ovv.1 uc008ovv.2 uc008ovv.3 uc008ovv.4 This gene encodes a member of a small family of proteins that play a key role in the response of cells to extracellular growth signals. The encoded protein regulates members of the transforming growth factor beta signaling pathway. It is highly expressed in certain cancer cells, where it may have both tumor-suppressing and tumor-promoting roles. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]. May have regulatory role in cell division or differentiation in response to extracellular signals. Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Interacts with SMAD2, SMAD3 and RNF111. Interacts with WWP1 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60665-1; Sequence=Displayed; Name=2; IsoId=Q60665-2; Sequence=VSP_014265; Ubiquitinated by RNF111 and ARK2C, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling. Belongs to the SKI family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding acrosomal vesicle blastocyst formation lymphocyte homeostasis chromatin binding transcription corepressor activity protein binding nucleus cytoplasm cell cycle arrest transforming growth factor beta receptor signaling pathway spermatogenesis skeletal muscle tissue development PML body protein domain specific binding negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway macromolecular complex response to cytokine macromolecular complex binding negative regulation of cell differentiation SMAD binding positive regulation of axonogenesis protein homotrimerization protein heterotrimerization lens fiber cell differentiation response to growth factor positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage uc008ovv.1 uc008ovv.2 uc008ovv.3 uc008ovv.4 
ENSMUST00000029196.5 Slc2a10 ENSMUST00000029196.5 solute carrier family 2 (facilitated glucose transporter), member 10 (from RefSeq NM_130451.3) ENSMUST00000029196.1 ENSMUST00000029196.2 ENSMUST00000029196.3 ENSMUST00000029196.4 GTR10_MOUSE Glut10 NM_130451 Q8VHD6 Slc2a10 uc008nxv.1 uc008nxv.2 uc008nxv.3 uc008nxv.4 This gene encodes a class III facilitative glucose transporter. Mutations in the related gene in human are associated with arterial tortuosity syndrome. [provided by RefSeq, Dec 2013]. ##Evidence-Data-START## Transcript exon combination :: AK052156.1, AY029579.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Facilitative glucose transporter required for the development of the cardiovascular system. Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, ChEBI:CHEBI:4167; Evidence=; Endomembrane system ; Multi-pass membrane protein Cytoplasm, perinuclear region Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. sugar:proton symporter activity glucose transmembrane transporter activity cytoplasm integral component of plasma membrane carbohydrate transport endomembrane system membrane integral component of membrane transmembrane transporter activity perinuclear region of cytoplasm transmembrane transport hydrogen ion transmembrane transport glucose transmembrane transport uc008nxv.1 uc008nxv.2 uc008nxv.3 uc008nxv.4 
ENSMUST00000029199.11 Zmat3 ENSMUST00000029199.11 zinc finger matrin type 3 (from RefSeq NM_009517.2) B9EI21 B9EI21_MOUSE ENSMUST00000029199.1 ENSMUST00000029199.10 ENSMUST00000029199.2 ENSMUST00000029199.3 ENSMUST00000029199.4 ENSMUST00000029199.5 ENSMUST00000029199.6 ENSMUST00000029199.7 ENSMUST00000029199.8 ENSMUST00000029199.9 NM_009517 Zmat3 uc008owc.1 uc008owc.2 uc008owc.3 uc008owc.4 nucleic acid binding nucleoplasm nucleolus plasma membrane zinc ion binding positive regulation of apoptotic process metal ion binding uc008owc.1 uc008owc.2 uc008owc.3 uc008owc.4 
ENSMUST00000029208.15 Slc13a3 ENSMUST00000029208.15 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (from RefSeq NM_054055.2) ENSMUST00000029208.1 ENSMUST00000029208.10 ENSMUST00000029208.11 ENSMUST00000029208.12 ENSMUST00000029208.13 ENSMUST00000029208.14 ENSMUST00000029208.2 ENSMUST00000029208.3 ENSMUST00000029208.4 ENSMUST00000029208.5 ENSMUST00000029208.6 ENSMUST00000029208.7 ENSMUST00000029208.8 ENSMUST00000029208.9 NM_054055 Nadc3 Q91Y63 S13A3_MOUSE Sdct2 uc008nxs.1 uc008nxs.2 uc008nxs.3 High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate (PubMed:11287335). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:11287335). Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (By similarity). Reaction=3 Na(+)(out) + succinate(out) = 3 Na(+)(in) + succinate(in); Xref=Rhea:RHEA:71919, ChEBI:CHEBI:29101, ChEBI:CHEBI:30031; Evidence=; Reaction=2-oxoglutarate(out) + 3 Na(+)(out) = 2-oxoglutarate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:71939, ChEBI:CHEBI:16810, ChEBI:CHEBI:29101; Evidence=; Reaction=N-acetyl-L-aspartate(out) + 3 Na(+)(out) = N-acetyl-L- aspartate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:71947, ChEBI:CHEBI:16953, ChEBI:CHEBI:29101; Evidence=; Reaction=fumarate(out) + 3 Na(+)(out) = fumarate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:71931, ChEBI:CHEBI:29101, ChEBI:CHEBI:29806; Evidence=; Reaction=glutarate(out) + 3 Na(+)(out) = glutarate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:71955, ChEBI:CHEBI:29101, ChEBI:CHEBI:30921; Evidence=; Reaction=2,2-dimethylsuccinate(out) + 3 Na(+)(out) = 2,2- dimethylsuccinate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:72287, ChEBI:CHEBI:29101, ChEBI:CHEBI:191383; Evidence=; Reaction=2,3-dimethylsuccinate(out) + 3 Na(+)(out) = 2,3- dimethylsuccinate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:72291, ChEBI:CHEBI:29101, ChEBI:CHEBI:191384; Evidence=; Reaction=malate(out) + 3 Na(+)(out) = malate(in) + 3 Na(+)(in); Xref=Rhea:RHEA:72295, ChEBI:CHEBI:15595, ChEBI:CHEBI:29101; Evidence=; Kinetic parameters: KM=100 uM for succinate ; Cell membrane; Multi-pass membrane protein. Highly expressed in kidney, and at much lower levels in brain. Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. dicarboxylic acid transmembrane transporter activity organic acid:sodium symporter activity plasma membrane ion transport sodium ion transport dicarboxylic acid transport citrate transmembrane transporter activity alpha-ketoglutarate transmembrane transporter activity succinate transmembrane transporter activity L-aspartate transmembrane transporter activity symporter activity high-affinity sodium:dicarboxylate symporter activity alpha-ketoglutarate transport succinate transport citrate transport aspartate transport membrane integral component of membrane sodium:dicarboxylate symporter activity transmembrane transporter activity transmembrane transport L-aspartate transport succinate transmembrane transport uc008nxs.1 uc008nxs.2 uc008nxs.3 
ENSMUST00000029213.5 Ocstamp ENSMUST00000029213.5 osteoclast stimulatory transmembrane protein (from RefSeq NM_029021.1) ENSMUST00000029213.1 ENSMUST00000029213.2 ENSMUST00000029213.3 ENSMUST00000029213.4 NM_029021 OCSTP_MOUSE Q8C046 Q9D611 uc008nxr.1 uc008nxr.2 uc008nxr.3 Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation. Membrane ; Multi-pass membrane protein Expressed in osteoclast (at protein level). Ubiquitous. Highly expressed in multi-nuclear osteoclast cells compared to mono-nuclear macrophages. Expressed in foreign body giant cells (FBGCs). Up-regulated during osteoclast and foreign body giant cells (FBGCs) differentiation by TNFSF11 and cytokines. Down-regulated by estrogen. Mice show a lack of multi-nuclear osteoclast and foreign body giant cell formation and a bone-resorbing efficiency reduction. Sequence=BAC27818.1; Type=Frameshift; Evidence=; molecular_function cellular_component membrane integral component of membrane cell differentiation positive regulation of macrophage fusion positive regulation of osteoclast differentiation cellular response to tumor necrosis factor cellular response to estrogen stimulus multinuclear osteoclast differentiation positive regulation of osteoclast proliferation uc008nxr.1 uc008nxr.2 uc008nxr.3 
ENSMUST00000029214.14 Actl6a ENSMUST00000029214.14 actin-like 6A (from RefSeq NM_019673.2) ACL6A_MOUSE Actl6 Baf53a ENSMUST00000029214.1 ENSMUST00000029214.10 ENSMUST00000029214.11 ENSMUST00000029214.12 ENSMUST00000029214.13 ENSMUST00000029214.2 ENSMUST00000029214.3 ENSMUST00000029214.4 ENSMUST00000029214.5 ENSMUST00000029214.6 ENSMUST00000029214.7 ENSMUST00000029214.8 ENSMUST00000029214.9 NM_019673 Q8C1W3 Q99M56 Q9Z2N8 uc012coo.1 uc012coo.2 uc012coo.3 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair (By similarity). Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3 (Probable). Component of the BAF53 complex, at least composed of ACTL6A/BAF53A, RUVBL1/TIP49, SMARCA2/BRM/BAF190B and TRRAP/PAF400, and which may also include a HAT activity related to, but distinct from, that of KAT5. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). May be a component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (By similarity). Interacts with SMARCA4/BRG1/BAF190A (By similarity). Interacts with PHF10/BAF45A (PubMed:17640523). Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80 (By similarity). Interacts with DPF2 (By similarity). Nucleus Widely expressed. Expressed selectively in neural stem and progenitor cells (at protein level). Expressed predominantly in 10.5 dpc-11.5 dpc neural cells. In the developing spinal cord (10.5 dpc-16.5 dpc), is specifically expressed in proliferating neural progenitors of the ventricular zone. In the developing forebrain and cerebellar primordium, expression is restricted to proliferating neuroepithelial progenitors and cerebellar granule precursors. Belongs to the actin family. blastocyst formation neural retina development chromatin binding protein binding nucleus nucleoplasm plasma membrane DNA repair DNA recombination chromatin organization chromatin remodeling regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus nervous system development SWI/SNF complex spinal cord development Ino80 complex NuA4 histone acetyltransferase complex regulation of growth ATP-dependent chromatin remodeling histone H4 acetylation histone H2A acetylation npBAF complex uc012coo.1 uc012coo.2 uc012coo.3 
ENSMUST00000029222.8 Ccdc39 ENSMUST00000029222.8 coiled-coil domain containing 39 (from RefSeq NM_026222.3) B2RSM0 CCD39_MOUSE Ccdc39 D3Ertd789e ENSMUST00000029222.1 ENSMUST00000029222.2 ENSMUST00000029222.3 ENSMUST00000029222.4 ENSMUST00000029222.5 ENSMUST00000029222.6 ENSMUST00000029222.7 NM_026222 Q8CDG6 Q9D5Y1 uc008oxi.1 uc008oxi.2 uc008oxi.3 Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. Cytoplasm, cytoskeleton, cilium axoneme Note=CCDC40 is required for localization to axonemes. Strongly expressed in tissues rich in ciliated cells. Expressed in olfactory and vomeronasal sensory neurons and the respiratory epithelium. Expressed in node cells carrying motile cilia, in upper and lower airways, and in ependymal and choroid plexus cells. Belongs to the CCDC39 family. heart looping cilium movement epithelial cilium movement regulation of cilium beat frequency molecular_function extracellular region cytoplasm cytosol cytoskeleton cilium axoneme determination of left/right symmetry brain development heart development flagellated sperm motility lung development determination of pancreatic left/right asymmetry inner dynein arm assembly cell projection motile cilium assembly cilium-dependent cell motility epithelial cilium movement involved in determination of left/right asymmetry protein localization to cilium axonemal dynein complex assembly determination of digestive tract left/right asymmetry determination of liver left/right asymmetry cerebrospinal fluid circulation 9+2 motile cilium uc008oxi.1 uc008oxi.2 uc008oxi.3 
ENSMUST00000029240.14 Slc2a2 ENSMUST00000029240.14 solute carrier family 2 (facilitated glucose transporter), member 2 (from RefSeq NM_031197.2) ENSMUST00000029240.1 ENSMUST00000029240.10 ENSMUST00000029240.11 ENSMUST00000029240.12 ENSMUST00000029240.13 ENSMUST00000029240.2 ENSMUST00000029240.3 ENSMUST00000029240.4 ENSMUST00000029240.5 ENSMUST00000029240.6 ENSMUST00000029240.7 ENSMUST00000029240.8 ENSMUST00000029240.9 GTR2_MOUSE Glut2 NM_031197 P14246 Q3TNA5 Q9DBA7 Slc2a2 uc008oua.1 uc008oua.2 uc008oua.3 uc008oua.4 uc008oua.5 Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate. Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, ChEBI:CHEBI:4167; Evidence=; Reaction=D-fructose(out) = D-fructose(in); Xref=Rhea:RHEA:60372, ChEBI:CHEBI:37721; Evidence=; Reaction=L-dehydroascorbate(out) = L-dehydroascorbate(in); Xref=Rhea:RHEA:60380, ChEBI:CHEBI:58539; Evidence=; Reaction=D-galactose(in) = D-galactose(out); Xref=Rhea:RHEA:34915, ChEBI:CHEBI:4139; Evidence=; D-glucose and maltose competitively inhibit fructose transport. D-glucose, D-fructose and maltose inhibit deoxyglucose transport. Cell membrane ; Multi-pass membrane protein In embryo, expressed in endoderm layer of yolk sac and liver primordium. N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. insulin receptor binding fructose transmembrane transporter activity glucose transmembrane transporter activity cytoplasm endosome cytosol plasma membrane brush border cell-cell junction carbohydrate transport carbohydrate utilization fructose transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane transmembrane transporter activity endocrine pancreas development brush border membrane dehydroascorbic acid transporter activity D-glucose transmembrane transporter activity transmembrane transport dehydroascorbic acid transport glucose transmembrane transport uc008oua.1 uc008oua.2 uc008oua.3 uc008oua.4 uc008oua.5 
ENSMUST00000029252.8 Lrrc34 ENSMUST00000029252.8 leucine rich repeat containing 34 (from RefSeq NM_027941.1) A0AUN5 ENSMUST00000029252.1 ENSMUST00000029252.2 ENSMUST00000029252.3 ENSMUST00000029252.4 ENSMUST00000029252.5 ENSMUST00000029252.6 ENSMUST00000029252.7 LRC34_MOUSE Lrrc34 NM_027941 Q14B04 Q9DAM1 Spata34 uc008ovb.1 uc008ovb.2 uc008ovb.3 Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. Interacts with NPM1 and NCL. Nucleus cleus, nucleolus Cytoplasm te=As stem cells differentiate, translocates from the nucleolus to the nucleus and then to the cytoplasm. Colocalizes with NPM1 and NCL in the nucleolus. Expressed in testis where it specifically localizes to germ cells (at protein level) (PubMed:24435972, PubMed:24991885). Not detected in other tissues tested (at protein level) (PubMed:24435972, PubMed:24991885). Expressed in pluripotent embryonic stem cells and multipotent adult germline stem cells (PubMed:24991885). Detected in unfertilized oocytes; expression continues in preimplantation embryos though to the blastula stage (at protein level) (PubMed:24991885). In testis, detected in very early spermatogonial germ cells with expression continuing through to the elongated spermatid stage (at protein level) (PubMed:24435972, PubMed:24991885). Weakly expressed in spermatozoa (at protein level) (PubMed:24435972). Not detected in spermatozoa (at protein level) (PubMed:24991885). molecular_function cellular_component nucleus nucleolus cytoplasm biological_process cell differentiation uc008ovb.1 uc008ovb.2 uc008ovb.3 
ENSMUST00000029256.9 Sec62 ENSMUST00000029256.9 SEC62 homolog, preprotein translocation, transcript variant 2 (from RefSeq NM_027016.2) ENSMUST00000029256.1 ENSMUST00000029256.2 ENSMUST00000029256.3 ENSMUST00000029256.4 ENSMUST00000029256.5 ENSMUST00000029256.6 ENSMUST00000029256.7 ENSMUST00000029256.8 NM_027016 Q6NX81 Q8BU14 SEC62_MOUSE Tloc1 uc008ovh.1 uc008ovh.2 uc008ovh.3 Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. The ER translocon complex that consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63. Interacts with SEC61B. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the SEC62 family. endoplasmic reticulum endoplasmic reticulum membrane posttranslational protein targeting to membrane protein transport membrane integral component of membrane integral component of endoplasmic reticulum membrane posttranslational protein targeting to membrane, translocation uc008ovh.1 uc008ovh.2 uc008ovh.3 
ENSMUST00000029257.15 Atp11b ENSMUST00000029257.15 ATPase, class VI, type 11B, transcript variant 3 (from RefSeq NR_151627.1) AT11B_MOUSE Atp11b ENSMUST00000029257.1 ENSMUST00000029257.10 ENSMUST00000029257.11 ENSMUST00000029257.12 ENSMUST00000029257.13 ENSMUST00000029257.14 ENSMUST00000029257.2 ENSMUST00000029257.3 ENSMUST00000029257.4 ENSMUST00000029257.5 ENSMUST00000029257.6 ENSMUST00000029257.7 ENSMUST00000029257.8 ENSMUST00000029257.9 NR_151627 Q6DFW5 uc008oyt.1 uc008oyt.2 uc008oyt.3 Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes. May contribute to the maintenance of membrane lipid asymmetry in endosome compartment. Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38567, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57262, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38568; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:66132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:64612, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66133; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP11B and an accessory beta subunit TMEM30A. Recycling endosome membrane ; Multi-pass membrane protein Early endosome Endoplasmic reticulum Golgi apparatus, trans-Golgi network Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, mainly located in recycling endosomes. Expressed in retina, brain, liver, testes and kidney (at protein level). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. nucleotide binding magnesium ion binding ATP binding endoplasmic reticulum trans-Golgi network plasma membrane phospholipid transport membrane integral component of membrane phospholipid translocation recycling endosome uc008oyt.1 uc008oyt.2 uc008oyt.3 
ENSMUST00000029259.10 Mccc1 ENSMUST00000029259.10 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) (from RefSeq NM_023644.4) ENSMUST00000029259.1 ENSMUST00000029259.2 ENSMUST00000029259.3 ENSMUST00000029259.4 ENSMUST00000029259.5 ENSMUST00000029259.6 ENSMUST00000029259.7 ENSMUST00000029259.8 ENSMUST00000029259.9 MCCA_MOUSE Mcca NM_023644 Q3TGU0 Q99MR8 Q9D8R2 uc008oyy.1 uc008oyy.2 uc008oyy.3 uc008oyy.4 uc008oyy.5 uc008oyy.6 Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3- methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate; Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344, ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4; Evidence=; Name=biotin; Xref=ChEBI:CHEBI:57586; Evidence=; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy- 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3. Probably a dodecamer composed of six biotin-containing alpha subunits (MCCC1) and six beta (MCCC2) subunits (By similarity). Interacts (via the biotin carboxylation domain) with SIRT4 (PubMed:23438705). Mitochondrion matrix Acetylated. nucleotide binding 3-methylcrotonyl-CoA carboxylase complex, mitochondrial methylcrotonoyl-CoA carboxylase activity ATP binding mitochondrion mitochondrial inner membrane mitochondrial matrix leucine catabolic process ligase activity metal ion binding methylcrotonoyl-CoA carboxylase complex uc008oyy.1 uc008oyy.2 uc008oyy.3 uc008oyy.4 uc008oyy.5 uc008oyy.6 
ENSMUST00000029266.14 Anxa5 ENSMUST00000029266.14 annexin A5 (from RefSeq NM_009673.2) ANXA5_MOUSE Anx5 ENSMUST00000029266.1 ENSMUST00000029266.10 ENSMUST00000029266.11 ENSMUST00000029266.12 ENSMUST00000029266.13 ENSMUST00000029266.2 ENSMUST00000029266.3 ENSMUST00000029266.4 ENSMUST00000029266.5 ENSMUST00000029266.6 ENSMUST00000029266.7 ENSMUST00000029266.8 ENSMUST00000029266.9 NM_009673 P48036 Q3U5Q1 Q3U5X4 Q3U8K1 Q3UGV0 Q99LA1 uc008ozj.1 uc008ozj.2 uc008ozj.3 uc008ozj.4 uc008ozj.5 This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Monomer. Binds ATRX and EIF5B (By similarity). P48036; Q08460: Kcnma1; NbExp=4; IntAct=EBI-1184119, EBI-1633915; A pair of annexin repeats may form one binding site for calcium and phospholipid. The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex. S-nitrosylation is induced by interferon-gamma and oxidatively- modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex. Belongs to the annexin family. calcium-transporting ATPase activity calcium ion binding protein binding calcium-dependent phospholipid binding extracellular space nucleus cytoplasm endoplasmic reticulum cytosol plasma membrane blood coagulation hemostasis synaptic vesicle heparin binding external side of plasma membrane response to organic substance intercalated disc membrane peptide hormone binding Z disc negative regulation of blood coagulation dendrite receptor tyrosine kinase binding sarcolemma cell projection neuronal cell body positive regulation of apoptotic process perikaryon axon terminus negative regulation of coagulation protein homooligomerization negative regulation of sequestering of calcium ion response to calcium ion calcium ion transmembrane transport cellular response to lead ion endothelial microparticle response to thyroid hormone cellular response to gonadotropin-releasing hormone regulation of flagellated sperm motility negative regulation of prolactin secretion uc008ozj.1 uc008ozj.2 uc008ozj.3 uc008ozj.4 uc008ozj.5 
ENSMUST00000029268.7 1810062G17Rik ENSMUST00000029268.7 RIKEN cDNA 1810062G17 gene (from RefSeq NM_028183.1) 1810062G17Rik ENSMUST00000029268.1 ENSMUST00000029268.2 ENSMUST00000029268.3 ENSMUST00000029268.4 ENSMUST00000029268.5 ENSMUST00000029268.6 G3X8Y2 G3X8Y2_MOUSE NM_028183 uc029uli.1 uc029uli.2 molecular_function cellular_component biological_process uc029uli.1 uc029uli.2 
ENSMUST00000029269.12 Exosc9 ENSMUST00000029269.12 exosome component 9 (from RefSeq NM_019393.2) ENSMUST00000029269.1 ENSMUST00000029269.10 ENSMUST00000029269.11 ENSMUST00000029269.2 ENSMUST00000029269.3 ENSMUST00000029269.4 ENSMUST00000029269.5 ENSMUST00000029269.6 ENSMUST00000029269.7 ENSMUST00000029269.8 ENSMUST00000029269.9 EXOS9_MOUSE NM_019393 Pmscl1 Q9CSZ2 Q9JHI7 uc008ozm.1 uc008ozm.2 Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs (By similarity). Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts (via C-terminus region) with SETX (via N-terminus domain); the interaction enhances SETX sumoylation (By similarity). Cytoplasm Nucleus, nucleolus Nucleus Nucleus, nucleoplasm Note=Colocalizes with SETX in nuclear foci upon induction of transcription-related DNA damage at the S phase (By similarity). Belongs to the RNase PH family. The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active. nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) nuclear chromosome exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nuclear-transcribed mRNA catabolic process RNA polymerase II activating transcription factor binding RNA binding nucleus nucleoplasm nucleolus cytoplasm rRNA processing RNA processing rRNA catabolic process positive regulation of cell growth nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U1 snRNA 3'-end processing U4 snRNA 3'-end processing U5 snRNA 3'-end processing mRNA 3'-UTR AU-rich region binding exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay positive regulation of transcription from RNA polymerase II promoter nuclear mRNA surveillance nuclear polyadenylation-dependent rRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent mRNA catabolic process uc008ozm.1 uc008ozm.2 
ENSMUST00000029270.10 Ccna2 ENSMUST00000029270.10 cyclin A2 (from RefSeq NM_009828.3) CCNA2_MOUSE Ccna Ccna2 Cyca Cyca2 ENSMUST00000029270.1 ENSMUST00000029270.2 ENSMUST00000029270.3 ENSMUST00000029270.4 ENSMUST00000029270.5 ENSMUST00000029270.6 ENSMUST00000029270.7 ENSMUST00000029270.8 ENSMUST00000029270.9 NM_009828 P51943 Q61459 Q8BRG1 uc012cov.1 uc012cov.2 uc012cov.3 Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Interacts with the CDK1 and CDK2 protein kinases to form serine/threonine kinase holoenzyme complexes (PubMed:10068472). Interacts with CDK1 (hyperphosphorylated form in G1 and underphosphorylated forms in S and G2). Interacts with CDK2; the interaction increases from G1 to G2. Interacts (associated with CDK2 but not with CDK1) with SCAPER; regulates the activity of CCNA2/CDK2 by transiently maintaining CCNA2 in the cytoplasm. Forms a ternary complex with CDK2 and CDKN1B; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements (By similarity). Interacts with INCA1 (By similarity). (Microbial infection) Interacts with mouse cytomegalovirus/MCMV kinase M97; this interaction sequesters CCNA2 to the cytoplasm. P51943; P11440: Cdk1; NbExp=2; IntAct=EBI-846980, EBI-846949; P51943; P97377: Cdk2; NbExp=3; IntAct=EBI-846980, EBI-847048; P51943; P24941: CDK2; Xeno; NbExp=2; IntAct=EBI-846980, EBI-375096; Nucleus Cytoplasm Note=Exclusively nuclear during interphase. Detected in the nucleus and the cytoplasm at prophase. Cytoplasmic when associated with SCAPER. Ubiquitous (PubMed:8565853). In the testis, expressed in germ cells and in the ovary, in both germline and somatic cells (PubMed:8575639, PubMed:10068472). Accumulates steadily during G2 and is abruptly destroyed at mitosis. Expressed in spermatogonia and is most abundant in preleptotene spermatocytes, cells which will enter the meiotic pathway. Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase- promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. Belongs to the cyclin family. Cyclin AB subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity G2/M transition of mitotic cell cycle cyclin-dependent protein kinase holoenzyme complex female pronucleus male pronucleus protein binding nucleus nucleoplasm cytoplasm cytosol regulation of DNA replication cell cycle Ras protein signal transduction cyclin-dependent protein serine/threonine kinase regulator activity histone phosphorylation protein kinase binding protein domain specific binding animal organ regeneration response to estradiol response to glucagon cellular response to platelet-derived growth factor stimulus cellular response to leptin stimulus mitotic cell cycle phase transition cell cycle G1/S phase transition positive regulation of transcription, DNA-templated positive regulation of fibroblast proliferation cell division cellular response to cocaine cellular response to luteinizing hormone stimulus cellular response to estradiol stimulus cellular response to organic cyclic compound cellular response to hypoxia cellular response to nitric oxide cochlea development cyclin A2-CDK2 complex cyclin-dependent protein kinase activity cellular response to insulin-like growth factor stimulus protein kinase activity uc012cov.1 uc012cov.2 uc012cov.3 
ENSMUST00000029271.5 Trpc3 ENSMUST00000029271.5 transient receptor potential cation channel, subfamily C, member 3, transcript variant 1 (from RefSeq NM_019510.3) B1ATV3 ENSMUST00000029271.1 ENSMUST00000029271.2 ENSMUST00000029271.3 ENSMUST00000029271.4 NM_019510 Q61058 Q9QZC1 TRPC3_MOUSE Trp3 Trrp3 uc008ozt.1 uc008ozt.2 uc008ozt.3 Forms a receptor-activated non-selective calcium permeant cation channel. May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane- delimited fashion, independently of protein kinase C. Activated by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May be activated by internal calcium store depletion. Inhibited by intracellular Ca(2+). Homotetramer. Interacts with ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca(2+) homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation. Q9QZC1; Q13563: PKD2; Xeno; NbExp=3; IntAct=EBI-10051366, EBI-7813714; Cell membrane ; Multi-pass membrane protein Abundantly expressed in brain. Concentrated in cerebellar Purkinje cells and sparsely localized in cerebellar granule lyer, pontine nuclei and thalamus. Lower levels detected in other tissues. The cytoplasmic portion of the protein is required for channel assembly and gating. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily. ion channel activity calcium activated cation channel activity calcium channel activity plasma membrane integral component of plasma membrane ion transport calcium ion transport manganese ion transport single fertilization positive regulation of calcium ion transport into cytosol store-operated calcium channel activity membrane integral component of membrane response to ATP cation channel complex regulation of cytosolic calcium ion concentration response to calcium ion transmembrane transport calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding positive regulation of cardiac muscle hypertrophy in response to stress uc008ozt.1 uc008ozt.2 uc008ozt.3 
ENSMUST00000029273.8 Il21 ENSMUST00000029273.8 interleukin 21, transcript variant 2 (from RefSeq NM_021782.3) ENSMUST00000029273.1 ENSMUST00000029273.2 ENSMUST00000029273.3 ENSMUST00000029273.4 ENSMUST00000029273.5 ENSMUST00000029273.6 ENSMUST00000029273.7 IL21_MOUSE NM_021782 Q9ES17 uc008paj.1 uc008paj.2 uc008paj.3 uc008paj.4 Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (PubMed:15100251). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (PubMed:23045607). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15 (PubMed:11970879). May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (PubMed:12893770). Secreted Expressed in CD4(+) T cells. In CD4(+) T cells, expression is induced upon influenza virus infection by IL6. Mutants infected with influenza virus do not show a significant difference on germinal center B cells compared to wild- types (PubMed:23045607). Double knockouts for IL21 and IL6 infected with influenza virus show a significant reduction in germinal centers in both the draining lymphatic nodes and the spleens compared to wild- types. Animals show a significant reduction in virus-specific IgM and IgG (PubMed:23045607). Belongs to the IL-15/IL-21 family. B cell apoptotic process positive regulation of cytokine production positive regulation of natural killer cell cytokine production cytokine activity cytokine receptor binding interleukin-2 receptor binding extracellular region extracellular space immune response tyrosine phosphorylation of STAT protein positive regulation of cell proliferation positive regulation of B cell proliferation positive regulation of interleukin-10 production positive regulation of interleukin-17 production positive regulation of natural killer cell differentiation positive regulation of T cell proliferation positive regulation of tyrosine phosphorylation of STAT protein positive regulation of interferon-gamma biosynthetic process positive regulation of B cell differentiation positive regulation of natural killer cell mediated cytotoxicity cell maturation uc008paj.1 uc008paj.2 uc008paj.3 uc008paj.4 
ENSMUST00000029275.6 Il2 ENSMUST00000029275.6 interleukin 2 (from RefSeq NM_008366.3) ENSMUST00000029275.1 ENSMUST00000029275.2 ENSMUST00000029275.3 ENSMUST00000029275.4 ENSMUST00000029275.5 IL2_MOUSE Il-2 NM_008366 P04351 P97945 Q791T3 uc008pai.1 uc008pai.2 uc008pai.3 uc008pai.4 uc008pai.5 uc008pai.6 Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance (PubMed:9814585, PubMed:14614860). Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 (PubMed:14614860, PubMed:27018889). This process leads to activation of several pathways including STAT, phosphoinositide-3- kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance (PubMed:14614860). Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T- cells (PubMed:9814585). Secreted. Produced by immune cells including dendritic cells. In contrast, macrophages do not produce IL2 upon bacterial stimulation. By bacterial infection. The poly-Gln region is highly polymorphic. Mutant mice exhibit lethal autoimmunity and are impaired in regulatory T-cell production. After 4 to 5 weeks of birth, they develop a thymic disorder resulting in the disruption of thymocyte maturation. Belongs to the IL-2 family. negative regulation of protein phosphorylation positive regulation of protein phosphorylation adaptive immune response leukocyte activation involved in immune response immune system process negative regulation of B cell apoptotic process cytokine activity interleukin-2 receptor binding extracellular region extracellular space cell immune response G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration protein kinase C-activating G-protein coupled receptor signaling pathway growth factor activity carbohydrate binding positive regulation of B cell proliferation kappa-type opioid receptor binding positive regulation of interferon-gamma production positive regulation of interleukin-17 production positive regulation of T cell proliferation positive regulation of activated T cell proliferation positive regulation of tyrosine phosphorylation of STAT protein glycosphingolipid binding response to ethanol positive regulation of T cell differentiation positive regulation of regulatory T cell differentiation negative regulation of heart contraction positive regulation of transcription from RNA polymerase II promoter regulation of T cell homeostatic proliferation positive regulation of isotype switching to IgG isotypes negative regulation of lymphocyte proliferation negative regulation of inflammatory response positive regulation of immunoglobulin secretion positive regulation of dendritic spine development extrinsic apoptotic signaling pathway in absence of ligand negative regulation of T-helper 17 cell differentiation uc008pai.1 uc008pai.2 uc008pai.3 uc008pai.4 uc008pai.5 uc008pai.6 
ENSMUST00000029277.13 Afg2a ENSMUST00000029277.13 AFG2 AAA ATPase homolog A, transcript variant 2 (from RefSeq NM_021343.3) A0A0A0MQ80 A0A0A0MQ80_MOUSE Afg2a ENSMUST00000029277.1 ENSMUST00000029277.10 ENSMUST00000029277.11 ENSMUST00000029277.12 ENSMUST00000029277.2 ENSMUST00000029277.3 ENSMUST00000029277.4 ENSMUST00000029277.5 ENSMUST00000029277.6 ENSMUST00000029277.7 ENSMUST00000029277.8 ENSMUST00000029277.9 NM_021343 Spata5 uc008pau.1 uc008pau.2 uc008pau.3 uc008pau.4 uc008pau.5 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.6; Evidence=; ATP binding uc008pau.1 uc008pau.2 uc008pau.3 uc008pau.4 uc008pau.5 
ENSMUST00000029297.6 Slc7a11 ENSMUST00000029297.6 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (from RefSeq NM_011990.2) ENSMUST00000029297.1 ENSMUST00000029297.2 ENSMUST00000029297.3 ENSMUST00000029297.4 ENSMUST00000029297.5 NM_011990 Q9WTR6 Slc7a11 XCT_MOUSE sut uc008pdi.1 uc008pdi.2 uc008pdi.3 Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:10206947, PubMed:12235164, PubMed:16144837, PubMed:16037214, PubMed:17035536) (Probable). Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for protection of cells from oxidative stress (PubMed:31396687, PubMed:16144837, PubMed:16037214, PubMed:17035536). The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L- cystine (PubMed:10206947). In addition, mediates the import of L- kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis (By similarity). Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis (By similarity). In vitro can also transport L-aspartate (By similarity). May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons (PubMed:17035536). Controls the production of pheomelanin pigment directly (PubMed:16037214). Reaction=L-cystine(out) + L-glutamate(in) = L-cystine(in) + L- glutamate(out); Xref=Rhea:RHEA:70995, ChEBI:CHEBI:29985, ChEBI:CHEBI:35491; Evidence= Reaction=an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha- amino acid(out) + L-kynurenine(in); Xref=Rhea:RHEA:71191, ChEBI:CHEBI:57959, ChEBI:CHEBI:59869; Evidence=; Reaction=L-glutamate(in) + N-acetyl-L-cysteine(out) = L-glutamate(out) + N-acetyl-L-cysteine(in); Xref=Rhea:RHEA:74567, ChEBI:CHEBI:29985, ChEBI:CHEBI:78236; Evidence=; Kinetic parameters: KM=0.081 mM for L-cystine ; KM=0.16 mM for L-glutamate ; Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc; this interaction mediates cell membrane localization. Cell membrane ; Multi-pass membrane protein Cell projection, microvillus membrane ; Multi- pass membrane protein Note=Localized to the microvillous membrane of the placental syncytiotrophoblast. Expressed in cornea, lens, and retina (at protein level), namely in the corneal epithelium, lens epithelium and cortical fiber cells. Induced by diethyl maleate (PubMed:12235164). Up-regulated by lipopolysaccharide (LPS) and oxygen (PubMed:11136724). Ubiquitinated by TRIM26; leading to proteasomal degradation. Homozygous mice lacking SLC7A11 are healthy in appearance at the age of 6 months, develop normally and both males and females are fertile (PubMed:16144837). Mice contain approximately the double of plasma L-cystine concentration and approximately the half of glutathione concentration compare to the wild-type mice (PubMed:16144837). Subtle gray (sut) homozygous mice have reduced yellow hair pigment but the black pigment seems unaffected (PubMed:16037214). Sut mice exhibit a normal body weight but brain size is significantly reduced indicating an atrophy in certain brain tissues. Indeed, sut/sut mice exhibit pronounced enlargement of the ventricles, accompanied by thinning of the cortex and shrinkage of the striatum (PubMed:17035536). Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. rough endoplasmic reticulum cytoskeleton plasma membrane glutathione metabolic process amino acid transport response to oxidative stress brain development visual learning response to toxic substance cell surface response to organic cyclic compound L-amino acid transmembrane transporter activity membrane integral component of membrane ventricular system development striatum development transmembrane transporter activity adult behavior brush border membrane regulation of neutrophil apoptotic process cellular response to oxidative stress glutathione transmembrane transport response to nicotine regulation of cell proliferation intracellular membrane-bounded organelle regulation of melanin biosynthetic process lung alveolus development modulation of synaptic transmission regulation of synapse organization regulation of protein transport response to redox state transmembrane transport limb development lens fiber cell differentiation platelet aggregation organic substance transport glutamate homeostasis astrocyte projection L-glutamate import across plasma membrane regulation of cellular response to oxidative stress regulation of cysteine metabolic process negative regulation of oxidative stress-induced neuron death regulation of glutathione biosynthetic process regulation of AMPA glutamate receptor clustering regulation of glutamate metabolic process uc008pdi.1 uc008pdi.2 uc008pdi.3 
ENSMUST00000029303.13 Naa15 ENSMUST00000029303.13 N(alpha)-acetyltransferase 15, NatA auxiliary subunit (from RefSeq NM_053089.3) ENSMUST00000029303.1 ENSMUST00000029303.10 ENSMUST00000029303.11 ENSMUST00000029303.12 ENSMUST00000029303.2 ENSMUST00000029303.3 ENSMUST00000029303.4 ENSMUST00000029303.5 ENSMUST00000029303.6 ENSMUST00000029303.7 ENSMUST00000029303.8 ENSMUST00000029303.9 G3X8Y3 G3X8Y3_MOUSE NM_053089 Naa15 uc008pdz.1 uc008pdz.2 uc008pdz.3 nucleus transcription factor complex cytoplasm cytosol N-terminal protein amino acid acetylation acetyltransferase activity NatA complex ribosome binding negative regulation of apoptotic process positive regulation of transcription, DNA-templated protein stabilization uc008pdz.1 uc008pdz.2 uc008pdz.3 
ENSMUST00000029307.4 Stoml3 ENSMUST00000029307.4 stomatin (Epb7.2)-like 3 (from RefSeq NM_153156.2) ENSMUST00000029307.1 ENSMUST00000029307.2 ENSMUST00000029307.3 NM_153156 Q66JM3 Q6PE84 Q8K4P4 STML3_MOUSE Sro uc008pew.1 uc008pew.2 uc008pew.3 Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations. Homodimer. Interacts with PIEZO1 and PIEZO2. Cell membrane ingle-pass type III membrane protein Note=Detected in lipid rafts, in apical dendrites and in olfactory cilia. Expressed by all dorsal root ganglion neurons and is selectively expressed in neuronal tissues. Detected in olfactory epithelium. In deficient mice 35% of skin mechanoreceptors do not respond to mechanical stimuli. In addition, mechanosensitive ion channels find in many sensory neurons do not function. Tactile-driven behaviors are also impaired in mutant mice, including touch-evoked pain caused by neuropathic injury. Belongs to the band 7/mec-2 family. Sequence=AAH58224.1; Type=Erroneous initiation; Evidence=; Sequence=AAH80859.1; Type=Erroneous initiation; Evidence=; protein binding plasma membrane cilium signal transduction membrane integral component of membrane membrane raft uc008pew.1 uc008pew.2 uc008pew.3 
ENSMUST00000029311.11 Trpc4 ENSMUST00000029311.11 transient receptor potential cation channel, subfamily C, member 4, transcript variant 4 (from RefSeq NR_046161.1) ENSMUST00000029311.1 ENSMUST00000029311.10 ENSMUST00000029311.2 ENSMUST00000029311.3 ENSMUST00000029311.4 ENSMUST00000029311.5 ENSMUST00000029311.6 ENSMUST00000029311.7 ENSMUST00000029311.8 ENSMUST00000029311.9 NR_046161 Q62350 Q9QUQ5 Q9QUQ9 Q9QZC0 TRPC4_MOUSE Trrp4 uc008pfd.1 uc008pfd.2 uc008pfd.3 Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium- selective (By similarity). May also be activated by intracellular calcium store depletion. Trpc4 deficient mice lack a store-operated calcium entry in endothelial cells. Homotetramer (PubMed:19070363). Heterotetramer with TRPC1 and/or TRPC5 (By similarity). Isoform alpha but not isoform beta interacts with ITPR1, ITPR2 and ITPR3 (By similarity). Interacts with NHERF1 (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts (via CIRB domain) with SESTD1 (via the spectrin 1 repeat) and SPTBN5 (via C-terminus) (By similarity). Interacts with CDH5 and CTNNB1 (By similarity). Interacts (via protein 4.1-binding domain) with EPB41L2 (By similarity). Interacts with TRPC4AP (PubMed:20458742). Interacts with PLSCR1 (PubMed:32110987). Membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=Alpha; IsoId=Q9QUQ5-1; Sequence=Displayed; Name=Beta; IsoId=Q9QUQ5-2; Sequence=VSP_006570; Abundantly expressed in brain (hippocampal CA1 pyramidal neurons, dentate gyrus granule cells, and cerebral cortical neurons, and in the septal nuclei and the mitral layer of olfactory bulb). Lower levels are detected in other tissues. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily. ion channel activity calcium channel activity protein binding cytoplasm plasma membrane integral component of plasma membrane caveola cell-cell junction ion transport calcium ion transport manganese ion transport beta-catenin binding cell surface gamma-aminobutyric acid secretion store-operated calcium channel activity membrane integral component of membrane basolateral plasma membrane cortical cytoskeleton macromolecular complex cation channel complex calcium channel complex membrane raft cadherin binding oligodendrocyte differentiation regulation of cytosolic calcium ion concentration regulation of calcium ion transport transmembrane transport calcium ion import calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding uc008pfd.1 uc008pfd.2 uc008pfd.3 
ENSMUST00000029316.16 Exosc8 ENSMUST00000029316.16 exosome component 8, transcript variant 2 (from RefSeq NM_027148.4) ENSMUST00000029316.1 ENSMUST00000029316.10 ENSMUST00000029316.11 ENSMUST00000029316.12 ENSMUST00000029316.13 ENSMUST00000029316.14 ENSMUST00000029316.15 ENSMUST00000029316.2 ENSMUST00000029316.3 ENSMUST00000029316.4 ENSMUST00000029316.5 ENSMUST00000029316.6 ENSMUST00000029316.7 ENSMUST00000029316.8 ENSMUST00000029316.9 EXOS8_MOUSE NM_027148 Q9D753 Rrp43 uc008pfq.1 uc008pfq.2 uc008pfq.3 uc008pfq.4 Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs (By similarity). Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure (By similarity). Q9D753; Q8K4E0: Alms1; NbExp=3; IntAct=EBI-8387079, EBI-6272972; Cytoplasm Nucleus, nucleolus Nucleus Belongs to the RNase PH family. nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA binding nucleus nucleolus cytoplasm rRNA processing RNA processing RNA catabolic process rRNA catabolic process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U1 snRNA 3'-end processing U4 snRNA 3'-end processing U5 snRNA 3'-end processing mRNA 3'-UTR AU-rich region binding identical protein binding exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay nuclear mRNA surveillance nuclear polyadenylation-dependent rRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent mRNA catabolic process uc008pfq.1 uc008pfq.2 uc008pfq.3 uc008pfq.4 
ENSMUST00000029325.5 Aadac ENSMUST00000029325.5 arylacetamide deacetylase (from RefSeq NM_023383.1) AAAD_MOUSE Aada ENSMUST00000029325.1 ENSMUST00000029325.2 ENSMUST00000029325.3 ENSMUST00000029325.4 NM_023383 Q8VCF2 Q99PG0 uc008piz.1 uc008piz.2 uc008piz.3 Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly (By similarity). Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence=; Endoplasmic reticulum membrane ; Single-pass type II membrane protein Microsome membrane ; Single-pass type II membrane protein Highest levels in liver with lower levels in jejunum and kidney. N-glycosylated. Belongs to the 'GDXG' lipolytic enzyme family. triglyceride lipase activity endoplasmic reticulum endoplasmic reticulum membrane catabolic process positive regulation of triglyceride catabolic process membrane integral component of membrane lipase activity hydrolase activity serine hydrolase activity deacetylase activity organelle membrane short-chain carboxylesterase activity intracellular membrane-bounded organelle carboxylic ester hydrolase activity uc008piz.1 uc008piz.2 uc008piz.3 
ENSMUST00000029326.6 Sucnr1 ENSMUST00000029326.6 succinate receptor 1 (from RefSeq NM_032400.2) ENSMUST00000029326.1 ENSMUST00000029326.2 ENSMUST00000029326.3 ENSMUST00000029326.4 ENSMUST00000029326.5 Gpr91 NM_032400 Q4V9V9 Q99MT6 SUCR1_MOUSE uc008pja.1 uc008pja.2 uc008pja.3 G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (PubMed:15141213). Succinate- SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasis (PubMed:27481132, PubMed:18820681, PubMed:30962591, PubMed:29735652). In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells (PubMed:27481132, PubMed:30962591). Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involoved in immune function (By similarity). In activated M1 macrophages, plays a pro-inflammatory role in response to LPS (PubMed:27481132). Expressed in dendritic cells, where it is involved in the sensing of immunological danger and enhances immunity. Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well as an enhancement of antigen-specific activation of helper T cells (PubMed:18820681). In the small intestine, mediates the activation of tuft cells by dietary succinate and triggers type 2 immunity (PubMed:29735652). In adipocytes, plays an important role in the control of energy metabolism. In response to succinate, controls leptin expression in an AMPK-JNK-CEBPA-dependent as well as circadian clock- regulated manner (PubMed:36977414). In muscle tissue, is expressed in non-muscle cells and coordinates muscle remodeling in response to the succinate produced during exercise training in a paracrine manner (PubMed:32946811). In retina, acts as a mediator of vessel growth during retinal development. In response to succinate, regulates the production of angiogenic factors, including VEGF, by retinal ganglion neurons (By similarity). Cell membrane ; Multi-pass membrane protein Predominantly expressed in the kidney (proximal and distal tubules and the juxtaglomerular apparatus). Weakly expressed in liver, spleen and small intestine. Highly expressed in immature dendritic cells, expression rapidly downregulates after maturation. Also expressed in macrophages (PubMed:18820681, PubMed:27481132). Specifically expressed in intestinal tuft cells (PubMed:29735652). Expression in whole muscle is attributable to major non-myofibrillar resident cell types, including stromal, endothelial and satellite cell populations (PubMed:32946811). Expression in activated M1 macrophages is induced by LPS as well as IL1B. Abolition of succinate-induced hypertension (PubMed:15141213). Mutants have less migration of Langerhans cells to draining lymph nodes and impaired tetanus toxoid-specific recall T cell responses (PubMed:18820681). Mutants show dimished immune responses to microbiota-derived succinate but respond normally to parasitic worm Nippostrongylus brasiliensis (PubMed:29735652). Conditional knockouts for adipose tissue show a higher body wight but have a total amount of white adipose tissue significantly lower than wild-types, whereas muscle mass is similar. They also have better glucose tolerance and insulin sensitivity. Upon high fat diet, mutants develop hepatic steatosis and glucose intolerance (PubMed:36977414). Myeloid conditional knockouts have adipose-tissue inflammation and glucose intolerance. They show an exacerbated diet-induced obesity (PubMed:27481132). Belongs to the G-protein coupled receptor 1 family. renin secretion into blood stream macrophage activation involved in immune response G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway cell surface membrane integral component of membrane interleukin-1 beta production signaling receptor activity glucose homeostasis positive regulation of inflammatory response positive regulation of chemotaxis response to calcium ion regulation of angiotensin metabolic process uc008pja.1 uc008pja.2 uc008pja.3 
ENSMUST00000029336.6 Dhx36 ENSMUST00000029336.6 DEAH-box helicase 36 (from RefSeq NM_028136.2) DHX36_MOUSE Ddx36 Dhx36 ENSMUST00000029336.1 ENSMUST00000029336.2 ENSMUST00000029336.3 ENSMUST00000029336.4 ENSMUST00000029336.5 G3X8Y4 Kiaa1488 Mlel1 NM_028136 Q6ZPP7 Q8VHK9 Q9CSE8 uc008pjn.1 uc008pjn.2 uc008pjn.3 uc008pjn.4 Multifunctional ATP-dependent helicase that unwinds G- quadruplex (G4) structures (PubMed:25611385). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:21703541, PubMed:21590736). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) (By similarity). Plays a role in genomic integrity (By similarity). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (By similarity). Plays a role in transcriptional regulation. Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:25611385) (By similarity). Plays a role in post-transcriptional regulation (By similarity). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (By similarity). Binds to the precursor-microRNA-134 (pre-miR- 134) terminal loop and regulates its transport into the synapto- dendritic compartment (By similarity). Involved in the pre-miR-134- dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (By similarity). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (By similarity). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (By similarity). Binds also to ARE sequences present in several mRNAs mediating exosome- mediated 3'-5' mRNA degradation (By similarity). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (PubMed:21703541). Required for the early embryonic development and hematopoiesis (PubMed:22422825). Involved in the regulation of cardioblast differentiation and proliferation during heart development (PubMed:26489465). Involved in spermatogonia differentiation (PubMed:25611385). May play a role in ossification (PubMed:21590736). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; ATPase activity is enhanced in the presence of homomeric poly(U) RNAs, but not by double-stranded DNA (dsDNA), double- stranded RNA (dsRNA) and tRNA. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this complex exists in resting cells with or without dsRNA poly(I:C) ligand stimulation (PubMed:21703541). Interacts (via C-terminus) with TICAM1 (via TIR domain) (PubMed:21703541). Interacts (via C-terminus) with DDX21; this interaction serves as bridges to TICAM1 (PubMed:21703541). Interacts with TERT; this interaction is dependent on the ability of DHX36 to bind to the G-quadruplex RNA (G4-RNA) structure present in the telomerase RNA template component (TERC). Interacts with DKC1; this interaction is dependent on the ability of DHX36 to bind to the G4-RNA structure present in TERC. Interacts with PARN; this interaction stimulates PARN to enhance uPA mRNA decay. Interacts with EXOSC3; this interaction occurs in a RNase-insensitive manner. Interacts with EXOSC10; this interaction occurs in a RNase-insensitive manner. Interacts with ILF3; this interaction occurs in a RNA-dependent manner. Interacts with ELAVL1; this interaction occurs in an RNA-dependent manner. Interacts with DDX5; this interaction occurs in a RNA-dependent manner. Interacts with DDX17; this interaction occurs in a RNA- dependent manner. Interacts with HDAC1; this interaction occurs in a RNA-dependent manner (By similarity) (PubMed:21590736). Interacts with HDAC3; this interaction occurs in a RNA-dependent manner (By similarity). Interacts with HDAC4 (PubMed:21590736). Interacts with AGO1. Interacts with AGO2 (By similarity). Interacts with ERCC6 (By similarity). Nucleus Cytoplasm Cytoplasm, cytosol Cytoplasm, Stress granule Nucleus speckle Chromosome, telomere Mitochondrion Perikaryon Cell projection, dendrite Cell projection, axon Note=Predominantly localized in the nucleus. Colocalizes with SRSF2 in nuclear speckles. Colocalizes with DDX5 in nucleolar caps upon transcription inhibition. Accumulates and colocalized with TIA1 in cytoplasmic stress granules (SGs) in an arsenite-, heat shock- and RNA-binding-dependent manner. Shuttles into and out of SGs in an ATPase-dependent manner (By similarity). Colocalizes in the cytosol with the multi-helicase-TICAM1 complex that translocates to the mitochondria upon poly(I:C) stimulation (PubMed:21703541). Expressed in spermatogonia stem cells and primary spermatocytes (at protein level) (PubMed:25611385). Expressed strongly in testis. Weakly expressed in heart, lung, liver, kidney, small intestine, spleen, lymphe node and thymus (PubMed:25611385). Expressed in the embryonic heart at 10.5 and increases from 14.5 to 16.5 dpc, and then gradually decreases until postnal day 7 (PubMed:26489465). Expressed during the testicular development from embryonic day 18.5 to postnatal day 35 (PubMed:25611385). The DHX36-specific motif (DSM) form folds into a DNA-binding- induced alpha-helix that together with the oligonucleotide and oligosaccharide-binding-fold-like (OB-fold-like) subdomain bind to Myc- promoter G4-DNA-containing structure in an ATP-dependent manner. Upon G4-DNA-binding, DHX36 pulls on DSM in the 3'-direction, inducing rearrangement of the RecA-like 1 and 2 and the degenerate-winged-helix (WH) regions; these rearrangements are propbably responsible for the ATP-independent repetitive G4-DNA unfolding activity, one residue at a time. Upon resolving of G4-DNA into separate nucleotide strands, and ATP hydrolysis, the apoprotein of DHX36 seems incompatible with G4-DNA- binding (By similarity). The N-terminus is necessary for its recruitment to cytoplasmic stress granules (SGs) upon arsenite-induced treatment (By similarity). Mice die at around embryonic 7 days post-coitum (dpc). Conditional knockout mice in the hematopoeitic system leads to hemolytic anemia, a reduction in blood platelet and erythroblast development (PubMed:22422825). Cardiac progenitor-cell-specific knockout mice die around 12.5 dpc and lead to abnormal cardiovascular development with a reduction in cardiomyocyte proliferation. Mice display increased NKX2-5 mRNA but decreased NKX2-5 protein levels, respectively, in the heart at 12.5 dpc compared to wild-type mice (PubMed:26489465). Male germ-cell-specific knockout mice lead to testicular hypoplasia development, due to spermatogonia differentiation block, meiosis initiation arrest as early as meiosis I stage and an absence of mature sperm in the epididymis (PubMed:25611385). Mice show several alteration in meiosis-related gene expression such as the differentiating spermatogonia markers KIT/c-kit (PubMed:25611385). Belongs to the DEAD box helicase family. DEAH subfamily. nucleotide binding magnesium ion binding chromosome, telomeric region RNA polymerase II core promoter proximal region sequence-specific DNA binding ossification G-quadruplex RNA binding immune system process positive regulation of myeloid dendritic cell cytokine production nucleic acid binding DNA binding DNA helicase activity single-stranded DNA binding RNA binding RNA helicase activity double-stranded RNA binding mRNA 3'-UTR binding helicase activity protein binding ATP binding nucleus chromosome cytoplasm mitochondrion cytosol regulation of transcription from RNA polymerase III promoter regulation of translation multicellular organism development spermatogenesis DNA-dependent ATPase activity response to virus cytoplasmic stress granule RNA secondary structure unwinding positive regulation of gene expression nuclear speck hydrolase activity negative regulation of translation cell differentiation axon dendrite positive regulation of mRNA 3'-end processing positive regulation of telomere maintenance DNA duplex unwinding cellular response to heat cellular response to UV mRNA 3'-UTR AU-rich region binding histone deacetylase binding cell projection positive regulation of I-kappaB kinase/NF-kappaB signaling perikaryon response to exogenous dsRNA regulation of mRNA stability transcription regulatory region DNA binding G-quadruplex DNA unwinding innate immune response positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development metal ion binding mRNA 5'-UTR binding defense response to virus G-quadruplex DNA binding positive regulation of cardioblast differentiation positive regulation of transcription initiation from RNA polymerase II promoter positive regulation of dendritic spine morphogenesis 3'-UTR-mediated mRNA destabilization telomerase RNA binding pre-miRNA binding telomerase RNA stabilization positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of hematopoietic progenitor cell differentiation regulation of transcription from RNA polymerase II promoter involved in spermatogenesis positive regulation of interferon-alpha secretion cellular response to arsenite ion positive regulation of telomere maintenance via telomere lengthening positive regulation of intracellular mRNA localization N6-methyladenosine-containing RNA binding positive regulation of cytoplasmic translation uc008pjn.1 uc008pjn.2 uc008pjn.3 uc008pjn.4 
ENSMUST00000029344.10 Mfsd1 ENSMUST00000029344.10 major facilitator superfamily domain containing 1 (from RefSeq NM_025813.3) ENSMUST00000029344.1 ENSMUST00000029344.2 ENSMUST00000029344.3 ENSMUST00000029344.4 ENSMUST00000029344.5 ENSMUST00000029344.6 ENSMUST00000029344.7 ENSMUST00000029344.8 ENSMUST00000029344.9 MFSD1_MOUSE NM_025813 Q3UWU0 Q8BVZ3 Q9DC37 uc008plp.1 uc008plp.2 uc008plp.3 Lysosomal transporter which is essential for liver homeostasis (PubMed:31661432). Required to maintain stability and lysosomal localization of GLMP (PubMed:31661432, PubMed:32959924). Homodimer (PubMed:32959924). Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1 (PubMed:31661432, PubMed:32959924). Lysosome membrane ulti-pass membrane protein In brain, expressed in the cortex, striatum hippocampus, hypothalamus, thalamus and brainstem (at protein level) (PubMed:27981419). Widely expressed with highest levels in kidney and spleen (at protein level) (PubMed:31661432). After 24 hours of starvation, up-regulated in the brainstem and down-regulated in the cortex and striatum (PubMed:27981419). Following 8 weeks of high-fat diet, down-regulated in brainstem and hypothalamus (PubMed:27981419). The dileucine internalization motif is required for lysosomal localization. Not N-glycosylated. Splenomegaly and development of severe liver disease characterized by extravasation of erythrocytes, sinusoidal damage, loss of liver sinusoidal endothelial cells (LSECs) and fibrosis (PubMed:31661432). Normal life span but there is a significantly higher occurrence of liver tumors in old animals of more than 1.5 years of age (PubMed:31661432). Significantly reduced levels of Glmp (PubMed:31661432, PubMed:32959924). Conditional knockout in LSECs results in a tuberous liver appearance (PubMed:31661432). Belongs to the major facilitator superfamily. molecular_function cellular_component integral component of plasma membrane biological_process membrane integral component of membrane transmembrane transport uc008plp.1 uc008plp.2 uc008plp.3 
ENSMUST00000029355.9 Ppm1l ENSMUST00000029355.9 protein phosphatase 1 (formerly 2C)-like (from RefSeq NM_178726.3) ENSMUST00000029355.1 ENSMUST00000029355.2 ENSMUST00000029355.3 ENSMUST00000029355.4 ENSMUST00000029355.5 ENSMUST00000029355.6 ENSMUST00000029355.7 ENSMUST00000029355.8 Kiaa4175 NM_178726 PPM1L_MOUSE Q3UGL2 Q810H0 Q8BHN0 Q8C021 Q8C1D5 Q9Z0T1 uc008pmg.1 uc008pmg.2 uc008pmg.3 uc008pmg.4 Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit. ; Interacts with MAP3K7/TAK1 and MAP3K5. Q8BHN0; Q9H3P7: ACBD3; Xeno; NbExp=3; IntAct=EBI-7970002, EBI-1791792; Q8BHN0; P27448: MARK3; Xeno; NbExp=3; IntAct=EBI-7970002, EBI-707595; Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BHN0-1; Sequence=Displayed; Name=2; IsoId=Q8BHN0-2; Sequence=VSP_016928, VSP_016929; Expressed in brain, heart, testis, liver, lung and skeletal muscle. Mice exhibit increased fat mass and higher plasma glucose levels compared to wild type mice. Male mice also exhibit a decrease in free fatty acids and higher blood pressure. Belongs to the PP2C family. Sequence=AAO43055.1; Type=Erroneous initiation; Evidence=; MAPK cascade catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity protein binding protein dephosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway membrane integral component of membrane hydrolase activity cation binding metal ion binding uc008pmg.1 uc008pmg.2 uc008pmg.3 uc008pmg.4 
ENSMUST00000029358.15 Nmd3 ENSMUST00000029358.15 NMD3 ribosome export adaptor, transcript variant 1 (from RefSeq NM_133787.3) ENSMUST00000029358.1 ENSMUST00000029358.10 ENSMUST00000029358.11 ENSMUST00000029358.12 ENSMUST00000029358.13 ENSMUST00000029358.14 ENSMUST00000029358.2 ENSMUST00000029358.3 ENSMUST00000029358.4 ENSMUST00000029358.5 ENSMUST00000029358.6 ENSMUST00000029358.7 ENSMUST00000029358.8 ENSMUST00000029358.9 NMD3_MOUSE NM_133787 Q3UPR1 Q8BM61 Q99L48 uc008pml.1 uc008pml.2 uc008pml.3 uc008pml.4 Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. Found in a 60S ribosomal subunit export complex with RAN and XPO1. Interacts with XPO1. Associates with pre-60S ribosomal particles. Cytoplasm Nucleus Note=Shuttles between the nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99L48-1; Sequence=Displayed; Name=2; IsoId=Q99L48-2; Sequence=VSP_032020, VSP_032021; Belongs to the NMD3 family. ribosomal large subunit export from nucleus nucleus nucleoplasm nucleolus cytoplasm protein transport protein binding, bridging positive regulation of protein binding ribosomal large subunit binding positive regulation of RNA biosynthetic process positive regulation of protein localization to nucleolus uc008pml.1 uc008pml.2 uc008pml.3 uc008pml.4 
ENSMUST00000029367.6 Bche ENSMUST00000029367.6 butyrylcholinesterase (from RefSeq NM_009738.3) CHLE_MOUSE ENSMUST00000029367.1 ENSMUST00000029367.2 ENSMUST00000029367.3 ENSMUST00000029367.4 ENSMUST00000029367.5 NM_009738 Q03311 Q543J3 uc008pmw.1 uc008pmw.2 uc008pmw.3 Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Reaction=an acylcholine + H2O = a carboxylate + choline + H(+); Xref=Rhea:RHEA:21964, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:35287; EC=3.1.1.8; Homotetramer; disulfide-linked. Dimer of dimers (By similarity). Secreted Present in most cells except erythrocytes. No visible phenotype; due to the presence of other cholinesterases. Hypersensitive to acetylcholinesterase inhibitors, such as huperzine and donepezil. Treatment with the acetylcholinesterase inhibitor donepezil causes convulsions and death within 3 hours of dosing. Belongs to the type-B carboxylesterase/lipase family. acetylcholinesterase activity cholinesterase activity extracellular region extracellular space nuclear envelope lumen endoplasmic reticulum endoplasmic reticulum lumen response to nutrient learning negative regulation of cell proliferation neuroblast differentiation membrane hydrolase activity choline metabolic process choline binding response to drug identical protein binding response to alkaloid negative regulation of synaptic transmission response to glucocorticoid response to folic acid carboxylic ester hydrolase activity uc008pmw.1 uc008pmw.2 uc008pmw.3 
ENSMUST00000029369.5 Sohlh2 ENSMUST00000029369.5 spermatogenesis and oogenesis specific basic helix-loop-helix 2 (from RefSeq NM_028937.3) ENSMUST00000029369.1 ENSMUST00000029369.2 ENSMUST00000029369.3 ENSMUST00000029369.4 NM_028937 Q4JI40 Q9D489 SOLH2_MOUSE Tohlh2 uc008pgi.1 uc008pgi.2 uc008pgi.3 uc008pgi.4 Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation (PubMed:22056784). Coordinates oocyte differentiation without affecting meiosis I (PubMed:28504655). Forms both hetero- and homodimers with SOHLH1. Nucleus toplasm Note=Translocates from the cytoplasm into the nucleus and the translocation is dependent on SOHLH1 protein expression. Preferentially expressed in the adult ovary and testis. Expressed in the majority of spermatogonia in adult animals, but not in the most undifferentiated spermatogonial population (PubMed:22056784). In the embryonic gonads it is expressed as early as 13.5 dpc and later. In 3-day-old postnatal ovaries, it is expressed within oocytes in germ cell clusters and primordial follicles. In the adult, it is expressed only in small follicles, primary primordial and primary follicles. In testis, it is exclusively present in spermatogonia. Present at postnatal day 5, when spermatogonia stem cells differentiate into type A spermatogonia. Absent in Sertoli cells or spermatocytes (at protein level). Expressed in the germline as early as 12.5 dpc and precedes SOHLH1 protein expression, which occurred circa 15.5 dpc. SOHLH1 appearance at 15.5 dpc correlates with SOHLH2 translocation from the cytoplasm into the nucleus (PubMed:28504655). Up-regulated in mice lacking Sohlh1. Knockout mice are infertile. Infertility could not be rescued by SOHLH1 or SOHLH2 transgene expression due to a lack of expression of either genes in rescued animals. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding primary ovarian follicle growth DNA binding nucleus cytoplasm regulation of transcription, DNA-templated multicellular organism development spermatogenesis oocyte differentiation regulation of gene expression cell differentiation protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity oogenesis uc008pgi.1 uc008pgi.2 uc008pgi.3 uc008pgi.4 
ENSMUST00000029371.3 Smad9 ENSMUST00000029371.3 SMAD family member 9 (from RefSeq NM_019483.5) ENSMUST00000029371.1 ENSMUST00000029371.2 Madh8 Madh9 NM_019483 Q8CFF9 Q9JIW5 SMAD9_MOUSE Smad8 uc008pfv.1 uc008pfv.2 uc008pfv.3 uc008pfv.4 This gene encodes a member of a family of proteins that act as downstream effectors of the bone morphogenetic protein (BMP) signaling pathway. The encoded protein is phosphorylated by BMP receptors, which stimulates its binding to SMAD4 and translocation into the nucleus, where it functions as a regulator of transcription. Activity of this protein is important for embryonic development. Mutation of this gene results in defects in pulmonary vasculature. [provided by RefSeq, Mar 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK137411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor- regulated SMAD (R-SMAD). Has been shown to be activated by activin type I receptor-like kinases (ALK-2, ALK-3, ALK-6) which stimulate heteromerization between SMAD9 and SMAD4. May play a role in osteoblast differentiation and maturation. Interaction with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit (By similarity). Interacts with RANBP3L (By similarity). Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase and activin type I receptor-like kinases (ALK-2, ALK- 3 and ALK-6). Belongs to the dwarfin/SMAD family. ureteric bud development Mullerian duct regression DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated protein phosphorylation transforming growth factor beta receptor signaling pathway BMP signaling pathway midbrain development hindbrain development positive regulation of cell differentiation positive regulation of transcription, DNA-templated metal ion binding cartilage development bone development SMAD protein signal transduction cellular response to organic cyclic compound uc008pfv.1 uc008pfv.2 uc008pfv.3 uc008pfv.4 
ENSMUST00000029374.8 Nbea ENSMUST00000029374.8 neurobeachin (from RefSeq NM_030595.1) ENSMUST00000029374.1 ENSMUST00000029374.2 ENSMUST00000029374.3 ENSMUST00000029374.4 ENSMUST00000029374.5 ENSMUST00000029374.6 ENSMUST00000029374.7 Lyst2 NBEA_MOUSE NM_030595 Q8C931 Q9EPM9 Q9EPN0 Q9EPN1 Q9WVM9 uc033htl.1 uc033htl.2 uc033htl.3 Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. May have a role in membrane trafficking. Interacts with RII subunit of PKA. Membrane ; Peripheral membrane protein Endomembrane system ; Peripheral membrane protein Postsynaptic cell membrane ; Peripheral membrane protein Note=Associated with pleomorphic tubulovesicular endomembranes near the trans sides of Golgi stacks and throughout the cell bodies and cell processes. Concentrated at the postsynaptic plasma membrane of a subpopulation of synapses. Event=Alternative splicing; Named isoforms=4; Name=1 ; IsoId=Q9EPN1-1; Sequence=Displayed; Name=2 ; IsoId=Q9EPN1-2; Sequence=VSP_050540; Name=3 ; IsoId=Q9EPN1-3; Sequence=VSP_050541; Name=4 ; IsoId=Q9EPN1-4; Sequence=VSP_050542; Forebrain, brainstem and cerebellum. Highly expressed in neonatal brain, levels decline in adults. RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. Belongs to the WD repeat neurobeachin family. trans-Golgi network cytosol plasma membrane protein targeting post-Golgi vesicle-mediated transport protein localization endomembrane system membrane protein kinase binding cell junction synapse postsynaptic membrane protein kinase A binding uc033htl.1 uc033htl.2 uc033htl.3 
ENSMUST00000029377.8 Tm4sf4 ENSMUST00000029377.8 transmembrane 4 superfamily member 4 (from RefSeq NM_145539.2) ENSMUST00000029377.1 ENSMUST00000029377.2 ENSMUST00000029377.3 ENSMUST00000029377.4 ENSMUST00000029377.5 ENSMUST00000029377.6 ENSMUST00000029377.7 NM_145539 Q3TMT3 Q3TMT3_MOUSE Tm4sf4 uc008pha.1 uc008pha.2 uc008pha.3 uc008pha.4 uc008pha.5 Membrane ; Multi- pass membrane protein Belongs to the L6 tetraspanin family. membrane integral component of membrane tissue regeneration uc008pha.1 uc008pha.2 uc008pha.3 uc008pha.4 uc008pha.5 
ENSMUST00000029380.14 Wwtr1 ENSMUST00000029380.14 WW domain containing transcription regulator 1, transcript variant 2 (from RefSeq NM_133784.3) ENSMUST00000029380.1 ENSMUST00000029380.10 ENSMUST00000029380.11 ENSMUST00000029380.12 ENSMUST00000029380.13 ENSMUST00000029380.2 ENSMUST00000029380.3 ENSMUST00000029380.4 ENSMUST00000029380.5 ENSMUST00000029380.6 ENSMUST00000029380.7 ENSMUST00000029380.8 ENSMUST00000029380.9 NM_133784 Q3UQ69 Q3UQM0 Q99KI4 Q9EPK5 Taz WWTR1_MOUSE uc008phb.1 uc008phb.2 uc008phb.3 uc008phb.4 This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]. Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:37215988). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (By similarity). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:21145499). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (By similarity). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (By similarity). Binds to SLC9A3R2 via the PDZ motif at the plasma membrane (PubMed:11118213). Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP (PubMed:11118213). Interacts (via coiled-coil domain) with SMAD2 (via MH1 domain), SMAD3 and SMAD4 (By similarity). Interacts with MED15 (By similarity). Interacts with PAX8 and NKX2-1 (By similarity). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (By similarity). Interacts (via WW domain) with PALS1 (PubMed:21145499). Interacts with LATS1 (PubMed:21145499). Interacts with YAP1 (when phosphorylated at 'Ser-112') (PubMed:21145499). Interacts (via WW domain) with PRRG4 (via cytoplasmic domain) (By similarity). Q9EPK5; O35625: Axin1; NbExp=4; IntAct=EBI-1211920, EBI-2365912; Q9EPK5; Q8IX12: CCAR1; Xeno; NbExp=5; IntAct=EBI-1211920, EBI-356265; Q9EPK5; P35222: CTNNB1; Xeno; NbExp=2; IntAct=EBI-1211920, EBI-491549; Q9EPK5; P23441: Nkx2-1; Xeno; NbExp=3; IntAct=EBI-1211920, EBI-1223127; Q9EPK5; Q07157: TJP1; Xeno; NbExp=4; IntAct=EBI-1211920, EBI-79553; Q9EPK5; Q95168: TJP2; Xeno; NbExp=4; IntAct=EBI-1211920, EBI-8304003; Nucleus toplasm ll membrane Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies (PubMed:11118213). When phosphorylated is retained in the cytoplasm by YWHAZ (PubMed:11118213). Can be retained in the nucleus by MED15 (By similarity). Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499). At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (PubMed:21145499). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EPK5-1; Sequence=Displayed; Name=2; IsoId=Q9EPK5-2; Sequence=VSP_026137; Highly expressed in kidney, heart, placenta and lung. The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes. Binds to transcription factors via its WW domain. Phosphorylated by LATS2 and STK3/MST2. Phosphorylation by LATS2 results in creation of 14-3-3 binding sites, retention in the cytoplasm, and functional inactivation (By similarity). Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export. Ubiquitinated at Lys-46; leading to proteasomal degradation. Deubiquitinated and stabilized by UCHL1 at Lys-46; leading to osteoclastogenesis inhibition. negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation tissue homeostasis negative regulation of protein phosphorylation heart process transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated negative regulation of protein kinase activity positive regulation of cell proliferation positive regulation of epithelial to mesenchymal transition protein ubiquitination nuclear body stem cell division SCF-dependent proteasomal ubiquitin-dependent protein catabolic process glomerulus development multicellular organism growth hippo signaling protein homodimerization activity negative regulation of fat cell differentiation positive regulation of transcription from RNA polymerase II promoter mesenchymal cell differentiation cilium assembly regulation of SMAD protein import into nucleus regulation of canonical Wnt signaling pathway kidney morphogenesis regulation of metanephric nephron tubule epithelial cell differentiation negative regulation of canonical Wnt signaling pathway uc008phb.1 uc008phb.2 uc008phb.3 uc008phb.4 
ENSMUST00000029382.13 Ppid ENSMUST00000029382.13 peptidylprolyl isomerase D (cyclophilin D), transcript variant 1 (from RefSeq NM_026352.4) ENSMUST00000029382.1 ENSMUST00000029382.10 ENSMUST00000029382.11 ENSMUST00000029382.12 ENSMUST00000029382.2 ENSMUST00000029382.3 ENSMUST00000029382.4 ENSMUST00000029382.5 ENSMUST00000029382.6 ENSMUST00000029382.7 ENSMUST00000029382.8 ENSMUST00000029382.9 NM_026352 PPID_MOUSE Ppid Q543G1 Q9CR16 uc008pnp.1 uc008pnp.2 uc008pnp.3 PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity region. Involved in regulation of UV radiation-induced apoptosis. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Less sensitive to inhibition by cyclosporin A than is CYP-18. Identified in ESR1 or NR3C1/GCR steroid receptor-chaperone complexes. Found in HSP90 chaperone complexes with kinase clients LCK or EIF2AK1. Two monomers associate with one HSP90 homodimer. Interacts with HSP90AA1. Interacts with HSP90AB1; PPID and FKBP4 compete for binding to HSP90AB1 and the interaction is mutually exclusive with the PPID:HSPA8 interaction. Interacts with HSPA8; PPID and STIP1 but not FKBP4 compete for binding to HSPA8 and the interaction is mutually exclusive with the PPID:HSP90AB1 interaction. Interacts with S100A1 and S100A2; the interactions dissociate the PPID:HSP90AA1 interaction. Interacts with S100A6. Interacts with MYB, ILF2, XRCC6, RACK1 and RPS3. Interacts with cytoplasmic dynein 1 intermediate chain (DYNC1I1 or DYNC1I2). Cytoplasm Nucleus, nucleolus Nucleus, nucleoplasm Belongs to the cyclophilin-type PPIase family. PPIase D subfamily. This protein should not be confused with mitochondrial peptidyl-prolyl cis-trans isomerase F (PPIF) which is often referred to as cyclophilin D or CypD. negative regulation of transcription from RNA polymerase II promoter protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity FK506 binding nucleus nucleoplasm nucleolus cytoplasm mitochondrion cytosol protein folding apoptotic process transcription factor binding protein transport cyclosporin A binding isomerase activity enzyme binding estrogen receptor binding Hsp70 protein binding heat shock protein binding lipid particle organization protein refolding positive regulation of apoptotic process positive regulation of viral genome replication positive regulation of protein secretion unfolded protein binding Hsp90 protein binding chaperone-mediated protein folding macromolecular complex assembly cellular response to UV-A uc008pnp.1 uc008pnp.2 uc008pnp.3 
ENSMUST00000029385.9 Serp1 ENSMUST00000029385.9 stress-associated endoplasmic reticulum protein 1 (from RefSeq NM_030685.3) D3Ucla1 ENSMUST00000029385.1 ENSMUST00000029385.2 ENSMUST00000029385.3 ENSMUST00000029385.4 ENSMUST00000029385.5 ENSMUST00000029385.6 ENSMUST00000029385.7 ENSMUST00000029385.8 NM_030685 Q3TMC9 Q9Z1W5 Ramp4 SERP1_MOUSE uc008phs.1 uc008phs.2 uc008phs.3 uc008phs.4 uc008phs.5 Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins. Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX. Membrane ; Single- pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Belongs to the RAMP4 family. skeletal system development endoplasmic reticulum endoplasmic reticulum membrane cytoplasmic microtubule glucose metabolic process protein glycosylation post-embryonic development multicellular organism aging protein transport membrane integral component of membrane endoplasmic reticulum unfolded protein response positive regulation of insulin secretion positive regulation of translation positive regulation of organ growth muscle organ morphogenesis positive regulation of growth hormone secretion uc008phs.1 uc008phs.2 uc008phs.3 uc008phs.4 uc008phs.5 
ENSMUST00000029386.14 Etfdh ENSMUST00000029386.14 electron transferring flavoprotein, dehydrogenase (from RefSeq NM_025794.2) ENSMUST00000029386.1 ENSMUST00000029386.10 ENSMUST00000029386.11 ENSMUST00000029386.12 ENSMUST00000029386.13 ENSMUST00000029386.2 ENSMUST00000029386.3 ENSMUST00000029386.4 ENSMUST00000029386.5 ENSMUST00000029386.6 ENSMUST00000029386.7 ENSMUST00000029386.8 ENSMUST00000029386.9 ETFD_MOUSE NM_025794 Q3U7K2 Q8BK82 Q921G7 Q9DCT9 uc008pnq.1 uc008pnq.2 uc008pnq.3 uc008pnq.4 Accepts electrons from ETF and reduces ubiquinone. Reaction=a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]; Xref=Rhea:RHEA:24052, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307; EC=1.5.5.1; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Monomer. Mitochondrion inner membrane Acetylation of Lys-95 and Lys-222 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the ETF-QO/FixC family. electron-transferring-flavoprotein dehydrogenase activity mitochondrion mitochondrial inner membrane response to oxidative stress electron carrier activity membrane oxidoreductase activity mitochondrial electron transfer flavoprotein complex electron transport chain respiratory electron transport chain integral component of mitochondrial inner membrane mitochondrial membrane fatty acid beta-oxidation using acyl-CoA dehydrogenase oxidoreductase activity, oxidizing metal ions with flavin as acceptor metal ion binding quinone binding ubiquinone binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding oxidation-reduction process uc008pnq.1 uc008pnq.2 uc008pnq.3 uc008pnq.4 
ENSMUST00000029387.15 Eif2a ENSMUST00000029387.15 eukaryotic translation initiation factor 2A, transcript variant 3 (from RefSeq NM_001411293.1) D3Ertd194e EIF2A_MOUSE ENSMUST00000029387.1 ENSMUST00000029387.10 ENSMUST00000029387.11 ENSMUST00000029387.12 ENSMUST00000029387.13 ENSMUST00000029387.14 ENSMUST00000029387.2 ENSMUST00000029387.3 ENSMUST00000029387.4 ENSMUST00000029387.5 ENSMUST00000029387.6 ENSMUST00000029387.7 ENSMUST00000029387.8 ENSMUST00000029387.9 NM_001411293 Q05C11 Q640P8 Q8BJW6 uc008phu.1 uc008phu.2 uc008phu.3 Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BJW6-1; Sequence=Displayed; Name=2; IsoId=Q8BJW6-2; Sequence=VSP_024977, VSP_024978; Belongs to the WD repeat EIF2A family. This gene should not be confused with EIF2S1, frequently called eIF2-alpha in the literature, and with which it shares the alias EIF2A. EIF2S1 is the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40S ribosomal subunit, the EIF2A protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Sequence=BAC37320.1; Type=Erroneous initiation; Evidence=; tRNA binding translation initiation factor activity cytoplasm eukaryotic translation initiation factor 2 complex translation translational initiation regulation of translation protein phosphorylation positive regulation of signal transduction cytosolic small ribosomal subunit endoplasmic reticulum unfolded protein response SREBP signaling pathway ribosome assembly ribosome binding response to amino acid starvation uc008phu.1 uc008phu.2 uc008phu.3 
ENSMUST00000029388.10 4930579G24Rik ENSMUST00000029388.10 RIKEN cDNA 4930579G24 gene (from RefSeq NM_029482.1) CD046_MOUSE ENSMUST00000029388.1 ENSMUST00000029388.2 ENSMUST00000029388.3 ENSMUST00000029388.4 ENSMUST00000029388.5 ENSMUST00000029388.6 ENSMUST00000029388.7 ENSMUST00000029388.8 ENSMUST00000029388.9 NM_029482 Q3UUX7 Q9D4P8 uc008pnu.1 uc008pnu.2 uc008pnu.3 uc008pnu.4 Cytoplasm molecular_function cellular_component cytoplasm biological_process uc008pnu.1 uc008pnu.2 uc008pnu.3 uc008pnu.4 
ENSMUST00000029405.8 Gmps ENSMUST00000029405.8 guanine monophosphate synthetase (from RefSeq NM_001033300.2) ENSMUST00000029405.1 ENSMUST00000029405.2 ENSMUST00000029405.3 ENSMUST00000029405.4 ENSMUST00000029405.5 ENSMUST00000029405.6 ENSMUST00000029405.7 GUAA_MOUSE NM_001033300 Q3TFR6 Q3THK7 Q3TIH1 Q3UJ21 Q3V343 Q66JZ6 uc008pke.1 uc008pke.2 uc008pke.3 Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate. Reaction=ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate; Xref=Rhea:RHEA:11680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57464, ChEBI:CHEBI:58115, ChEBI:CHEBI:58359, ChEBI:CHEBI:456215; EC=6.3.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11681; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Stimulated by dithiothreitol and inhibited by 2- mercaptoethanol, p-chloromercuribenzoate and hydroxylamine. Kinetic parameters: KM=0.0036 mM for XMP ; KM=0.28 mM for ATP ; KM=0.68 mM for glutamine ; Vmax=1.0 nmol/min/mg enzyme for XMP ; Vmax=1.1 nmol/min/mg enzyme for ATP ; Vmax=1.37 nmol/min/mg enzyme for glutamine ; pH dependence: Optimum pH is 7.6. ; Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. Homodimer. Cytoplasm, cytosol Sequence=BAE20667.1; Type=Frameshift; Evidence=; nucleotide binding GMP synthase activity GMP synthase (glutamine-hydrolyzing) activity ATP binding cytoplasm cytosol purine nucleotide biosynthetic process GMP biosynthetic process glutamine metabolic process pyrophosphatase activity ligase activity uc008pke.1 uc008pke.2 uc008pke.3 
ENSMUST00000029406.6 Vmn2r1 ENSMUST00000029406.6 vomeronasal 2, receptor 1, transcript variant 1 (from RefSeq NM_019918.2) ENSMUST00000029406.1 ENSMUST00000029406.2 ENSMUST00000029406.3 ENSMUST00000029406.4 ENSMUST00000029406.5 G3X8Y6 G3X8Y6_MOUSE NM_019918 Vmn2r1 uc008pkf.1 uc008pkf.2 uc008pkf.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane dendrite uc008pkf.1 uc008pkf.2 uc008pkf.3 
ENSMUST00000029414.12 Ssr3 ENSMUST00000029414.12 signal sequence receptor, gamma (from RefSeq NM_026155.3) ENSMUST00000029414.1 ENSMUST00000029414.10 ENSMUST00000029414.11 ENSMUST00000029414.2 ENSMUST00000029414.3 ENSMUST00000029414.4 ENSMUST00000029414.5 ENSMUST00000029414.6 ENSMUST00000029414.7 ENSMUST00000029414.8 ENSMUST00000029414.9 NM_026155 Q8C0Z8 Q9DCF9 SSRG_MOUSE uc008pkn.1 uc008pkn.2 uc008pkn.3 TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP- gamma. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DCF9-1; Sequence=Displayed; Name=2; IsoId=Q9DCF9-2; Sequence=VSP_013474, VSP_013475; Belongs to the TRAP-gamma family. endoplasmic reticulum endoplasmic reticulum membrane SRP-dependent cotranslational protein targeting to membrane membrane integral component of membrane uc008pkn.1 uc008pkn.2 uc008pkn.3 
ENSMUST00000029416.14 Ccnl1 ENSMUST00000029416.14 cyclin L1, transcript variant 1 (from RefSeq NM_019937.4) Ania6a CCNL1_MOUSE Ccn1 ENSMUST00000029416.1 ENSMUST00000029416.10 ENSMUST00000029416.11 ENSMUST00000029416.12 ENSMUST00000029416.13 ENSMUST00000029416.2 ENSMUST00000029416.3 ENSMUST00000029416.4 ENSMUST00000029416.5 ENSMUST00000029416.6 ENSMUST00000029416.7 ENSMUST00000029416.8 ENSMUST00000029416.9 NM_019937 Q52KE7 Q8BQ75 Q8R5H9 Q922K0 Q9CSZ3 Q9WV44 uc008pku.1 uc008pku.2 uc008pku.3 Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). May play a role in the regulation of RNA polymerase II (pol II). Inhibited by the CDK-specific inhibitor CDKN1A/p21. Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with CDK11A, CDK11B, CDK12 and CDK13. May form a ternary complex with CDK11B and casein kinase II (CKII). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 and SRSF7/SLU7 (By similarity) (PubMed:17261272). [Isoform 1]: Nucleus speckle Nucleus, nucleoplasm Note=Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. [Isoform 2]: Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Cyclin L alpha; IsoId=Q52KE7-1; Sequence=Displayed; Name=2; IsoId=Q52KE7-2; Sequence=VSP_016126, VSP_016127; Widely expressed (at protein level). Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity). [Isoform 1]: Found in the nucleus, with a speckled pattern of expression. [Isoform 2]: Found both in the nucleus and cytoplasm. Belongs to the cyclin family. Cyclin L subfamily. Sequence=AAD43568.1; Type=Frameshift; Evidence=; regulation of cyclin-dependent protein serine/threonine kinase activity protein binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter RNA processing transcription elongation factor complex cyclin-dependent protein serine/threonine kinase regulator activity nuclear speck uc008pku.1 uc008pku.2 uc008pku.3 
ENSMUST00000029419.8 Veph1 ENSMUST00000029419.8 ventricular zone expressed PH domain-containing 1 (from RefSeq NM_145820.3) A1A535 E9QP23 ENSMUST00000029419.1 ENSMUST00000029419.2 ENSMUST00000029419.3 ENSMUST00000029419.4 ENSMUST00000029419.5 ENSMUST00000029419.6 ENSMUST00000029419.7 MELT_MOUSE NM_145820 Q8K4P5 Q8K4P6 Q9CYR8 Veph uc008pkz.1 uc008pkz.2 uc008pkz.3 uc008pkz.4 Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. Interacts with TGFBR1. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=A1A535-1; Sequence=Displayed; Name=B; IsoId=A1A535-2; Sequence=VSP_027434; Specifically expressed in kidney and eye. In the eye, expressed in retinal pigmented epithelium but not in the neural retina. Strongly expressed in brain and eye from 12 dpc to 17 dpc. After birth, brain expression decreases, whereas eye expression remains stable. The PH domain is required for membrane targeting. No visible phenotype. Belongs to the MELT/VEPH family. molecular_function cellular_component plasma membrane membrane negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of SMAD protein import into nucleus uc008pkz.1 uc008pkz.2 uc008pkz.3 uc008pkz.4 
ENSMUST00000029421.6 Ptx3 ENSMUST00000029421.6 pentraxin related gene (from RefSeq NM_008987.3) ENSMUST00000029421.1 ENSMUST00000029421.2 ENSMUST00000029421.3 ENSMUST00000029421.4 ENSMUST00000029421.5 NM_008987 P48759 PTX3_MOUSE Q8VDF1 Tsg14 uc008pla.1 uc008pla.2 uc008pla.3 Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility. Homooctamer; disulfide-linked (By similarity). Binds to C1q. Secreted. ovarian cumulus expansion complement component C1q binding (1->3)-beta-D-glucan binding response to yeast protein binding extracellular region extracellular space opsonization extracellular matrix organization extracellular matrix identical protein binding negative regulation by host of viral exo-alpha-sialidase activity negative regulation by host of viral glycoprotein metabolic process innate immune response positive regulation of nitric oxide biosynthetic process negative regulation of viral entry into host cell virion binding positive regulation of phagocytosis negative regulation of exo-alpha-sialidase activity negative regulation of glycoprotein metabolic process uc008pla.1 uc008pla.2 uc008pla.3 
ENSMUST00000029422.14 Shox2 ENSMUST00000029422.14 SHOX homeobox 2, transcript variant 1 (from RefSeq NM_013665.1) ENSMUST00000029422.1 ENSMUST00000029422.10 ENSMUST00000029422.11 ENSMUST00000029422.12 ENSMUST00000029422.13 ENSMUST00000029422.2 ENSMUST00000029422.3 ENSMUST00000029422.4 ENSMUST00000029422.5 ENSMUST00000029422.6 ENSMUST00000029422.7 ENSMUST00000029422.8 ENSMUST00000029422.9 NM_013665 Og12x P70369 P70390 Prx3 SHOX2_MOUSE uc008ple.1 uc008ple.2 uc008ple.3 uc008ple.4 May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. May also have a role in heart development. Nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=OG12A, PRX3A; IsoId=P70390-1; Sequence=Displayed; Name=2; Synonyms=OG12B, PRX3B; IsoId=P70390-2; Sequence=VSP_002289; Highly expressed in striated muscle followed by liver, kidney, testis, brain, heart, lung and spleen. Expressed from 9 dpc to 16 dpc in the heart, otic region, maxillary and mandibular components of the first branchial arch, nasal processes, eyelid, midbrain, medulla oblongata, limbs, dorsal root ganglia and genital tubercle. Also expressed in non- neuronal structures around the oral cavity and in hip and shoulder regions and in mesenchyme surrounding the vertebrae. Belongs to the paired homeobox family. Bicoid subfamily. Sequence=AAC52831.1; Type=Erroneous initiation; Evidence=; Sequence=AAC52832.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding osteoblast differentiation positive regulation of mesenchymal cell proliferation chondrocyte differentiation chondrocyte development heart valve development cardiac atrium morphogenesis DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development embryonic limb morphogenesis regulation of chondrocyte differentiation embryonic forelimb morphogenesis sequence-specific DNA binding positive regulation of smoothened signaling pathway positive regulation of transcription from RNA polymerase II promoter embryonic digestive tract morphogenesis embryonic morphogenesis positive regulation of skeletal muscle fiber development positive regulation of axonogenesis embryonic skeletal joint morphogenesis cartilage development involved in endochondral bone morphogenesis muscle tissue morphogenesis regulation of branching morphogenesis of a nerve uc008ple.1 uc008ple.2 uc008ple.3 uc008ple.4 
ENSMUST00000029423.9 Serpini1 ENSMUST00000029423.9 serine (or cysteine) peptidase inhibitor, clade I, member 1, transcript variant 1 (from RefSeq NM_009250.3) ENSMUST00000029423.1 ENSMUST00000029423.2 ENSMUST00000029423.3 ENSMUST00000029423.4 ENSMUST00000029423.5 ENSMUST00000029423.6 ENSMUST00000029423.7 ENSMUST00000029423.8 NEUS_MOUSE NM_009250 O35684 Pi12 Q543F7 Q922U6 Spi17 uc008pne.1 uc008pne.2 uc008pne.3 uc008pne.4 Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9364046, PubMed:11557034). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable). Secreted Cytoplasmic vesicle, secretory vesicle lumen Perikaryon Detected in neurons in embryonic brain cortex (at protein level) (PubMed:17040209). During embryonic development mostly expressed in CNS (PubMed:9364046). In adult expressed in brain and much less in spinal cord, heart, kidney and testis (PubMed:9364046). Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular region extracellular space negative regulation of peptidase activity negative regulation of endopeptidase activity positive regulation of neuron projection development regulation of cell adhesion peptidase inhibitor activity cytoplasmic vesicle secretory granule lumen neuronal cell body perikaryon cytoplasmic vesicle lumen uc008pne.1 uc008pne.2 uc008pne.3 uc008pne.4 
ENSMUST00000029429.6 Wnt2b ENSMUST00000029429.6 wingless-type MMTV integration site family, member 2B (from RefSeq NM_009520.3) ENSMUST00000029429.1 ENSMUST00000029429.2 ENSMUST00000029429.3 ENSMUST00000029429.4 ENSMUST00000029429.5 NM_009520 O70283 O88530 Q544L3 WNT2B_MOUSE Wnt13 uc008qut.1 uc008qut.2 uc008qut.3 Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:19686689). Plays a redundant role in embryonic lung development (PubMed:19686689). Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD4 and FZD5 (By similarity). Secreted, extracellular space, extracellular matrix Secreted Detected at the dorsal midline at the level of the diencephalon and mesencephalon at 9.5 dpc. Detected at the level of the optic and otic vesicles at 9.5 dpc (PubMed:9545553). Detected in the lateral plate mesoderm surrounding the ventral aspect of the anterior foregut at 9.5 dpc (PubMed:19686689). Detected in the mesothelium encasing the lung, and at lower levels in the distal mesenchyme from 12.5 dpc to 14.5 dpc (PubMed:19686689). Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. No visible phenotype at birth (PubMed:19686689). Combined disruption of Wnt2 and Wnt2b leads to lung agenesis (PubMed:19686689). Belongs to the Wnt family. chondrocyte differentiation receptor binding frizzled binding protein binding extracellular region extracellular space signal transduction cell-cell signaling multicellular organism development male gonad development cellular response to starvation animal organ morphogenesis Wnt signaling pathway forebrain regionalization neuron differentiation intracellular membrane-bounded organelle cell fate commitment canonical Wnt signaling pathway lung induction mesenchymal-epithelial cell signaling hematopoietic stem cell proliferation positive regulation of branching involved in ureteric bud morphogenesis uc008qut.1 uc008qut.2 uc008qut.3 
ENSMUST00000029433.9 Ptpn22 ENSMUST00000029433.9 protein tyrosine phosphatase, non-receptor type 22 (lymphoid), transcript variant 1 (from RefSeq NM_008979.3) ENSMUST00000029433.1 ENSMUST00000029433.2 ENSMUST00000029433.3 ENSMUST00000029433.4 ENSMUST00000029433.5 ENSMUST00000029433.6 ENSMUST00000029433.7 ENSMUST00000029433.8 NM_008979 P29352 PTN22_MOUSE Ptpn8 Q7TMP9 uc008qtv.1 uc008qtv.2 uc008qtv.3 uc008qtv.4 Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (By similarity). Associates with and probably dephosphorylates CBL (By similarity). Dephosphorylates LCK at its activating 'Tyr-394' residue (By similarity). Dephosphorylates ZAP70 at its activating 'Tyr-492' residue (By similarity). Dephosphorylates the immune system activator SKAP2 (By similarity). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (PubMed:23871208). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (PubMed:16938887). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate; Xref=Rhea:RHEA:56532, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:131894; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56533; Evidence=; Interacts with CBL (By similarity). Interacts with CSK (PubMed:8890164, PubMed:11685249). Interacts with LPXN (PubMed:15786712). Interacts with TRAF3 (via MATH domain); the interaction promotes TRAF3 polyubiquitination (PubMed:23871208). Cytoplasm Brain (at protein level) (PubMed:16938887). Spleen, thymus, lymph node and bone marrow (PubMed:1373816). By lipopolysaccharides (LPS). Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases. Knockout reduces the conversion of phosphoanandamide (p-AEA) to AEA in the brain. Belongs to the protein-tyrosine phosphatase family. Non- receptor class 4 subfamily. positive regulation of defense response to virus by host immune system process regulation of leukocyte migration phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding nucleus cytoplasm protein dephosphorylation autophagy cytoplasmic side of plasma membrane negative regulation of autophagy positive regulation of gene expression negative regulation of gene expression dephosphorylation hydrolase activity phosphatase activity SH3 domain binding kinase binding T cell differentiation ubiquitin protein ligase binding lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production response to lipopolysaccharide negative regulation of tumor necrosis factor production regulation of natural killer cell proliferation positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 9 signaling pathway peptidyl-tyrosine dephosphorylation positive regulation of interferon-beta secretion phosphoanandamide dephosphorylation positive regulation of protein import into nucleus negative regulation of JUN kinase activity perinuclear region of cytoplasm regulation of peptidyl-tyrosine phosphorylation T cell receptor signaling pathway regulation of T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway negative regulation of T cell activation positive regulation of ERK1 and ERK2 cascade negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to muramyl dipeptide positive regulation of granzyme B production negative regulation of interleukin-6 secretion regulation of NIK/NF-kappaB signaling positive regulation of protein K63-linked ubiquitination positive regulation of interferon-gamma secretion positive regulation of interferon-alpha secretion regulation of calcium ion transmembrane transport negative regulation of p38MAPK cascade protein tyrosine kinase binding negative regulation of interleukin-8 secretion positive regulation of CD8-positive, alpha-beta T cell proliferation regulation of antigen processing and presentation uc008qtv.1 uc008qtv.2 uc008qtv.3 uc008qtv.4 
ENSMUST00000029435.15 Dclre1b ENSMUST00000029435.15 DNA cross-link repair 1B, transcript variant 1 (from RefSeq NM_133865.2) A0JLW2 B0V3N9 B0V3P0 DCR1B_MOUSE ENSMUST00000029435.1 ENSMUST00000029435.10 ENSMUST00000029435.11 ENSMUST00000029435.12 ENSMUST00000029435.13 ENSMUST00000029435.14 ENSMUST00000029435.2 ENSMUST00000029435.3 ENSMUST00000029435.4 ENSMUST00000029435.5 ENSMUST00000029435.6 ENSMUST00000029435.7 ENSMUST00000029435.8 ENSMUST00000029435.9 NM_133865 Q3U4P2 Q3UUC7 Q3UV92 Q6NXL4 Q8BN95 Q8BQS8 Q8C7W7 Q921S0 Snm1b uc008qtl.1 uc008qtl.2 uc008qtl.3 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (By similarity). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (By similarity). Reaction=a beta-lactam + H2O = a substituted beta-amino acid; Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627, ChEBI:CHEBI:140347; EC=3.5.2.6; Evidence=; Interacts with MUS81, MRE11 and FANCD2. Interacts with HSPA2, HSPA8 and HSPA14. Interacts with SPAG5 (By similarity). Interacts with TERF2; the interaction is direct. Chromosome, telomere Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C7W7-1; Sequence=Displayed; Name=2; IsoId=Q8C7W7-2; Sequence=VSP_015174; Name=3; IsoId=Q8C7W7-3; Sequence=VSP_015175, VSP_015176; The TBM domain mediates interaction with TERF2. Ubiquitinated, leading to its degradation. Interaction with TERF2 protects it from ubiquitination (By similarity). Embryos are smaller than wild-type embryos and neonates die during the first day after birth. Cells activate the ATM kinase at their telomeres in S phase and show leading-end telomere fusions which are accompanied by a reduction in the telomeric overhang signal. Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family. Sequence=AAH11094.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC39165.1; Type=Frameshift; Evidence=; Sequence=BAE23379.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; telomere maintenance chromosome, telomeric region nuclear chromosome, telomeric region damaged DNA binding nuclease activity exonuclease activity protein binding nucleus nucleoplasm chromosome cytoplasm centrosome microtubule organizing center cytoskeleton DNA repair nucleotide-excision repair double-strand break repair via nonhomologous end joining cellular response to DNA damage stimulus mitotic cell cycle checkpoint 5'-3' exonuclease activity telomere maintenance via telomere lengthening telomere capping nuclear body hydrolase activity telomeric loop formation protection from non-homologous end joining at telomere telomeric 3' overhang formation 5'-3' exodeoxyribonuclease activity interstrand cross-link repair protein homodimerization activity macromolecular complex binding nucleic acid phosphodiester bond hydrolysis uc008qtl.1 uc008qtl.2 uc008qtl.3 
ENSMUST00000029440.10 Olfml3 ENSMUST00000029440.10 olfactomedin-like 3 (from RefSeq NM_133859.2) A0A0R4J086 A0A0R4J086_MOUSE ENSMUST00000029440.1 ENSMUST00000029440.2 ENSMUST00000029440.3 ENSMUST00000029440.4 ENSMUST00000029440.5 ENSMUST00000029440.6 ENSMUST00000029440.7 ENSMUST00000029440.8 ENSMUST00000029440.9 NM_133859 Olfml3 uc008qtf.1 uc008qtf.2 uc008qtf.3 Belongs to the OLFML3 family. Lacks conserved residue(s) required for the propagation of feature annotation. uc008qtf.1 uc008qtf.2 uc008qtf.3 
ENSMUST00000029441.4 Syt10 ENSMUST00000029441.4 synaptotagmin X (from RefSeq NM_018803.2) ENSMUST00000029441.1 ENSMUST00000029441.2 ENSMUST00000029441.3 NM_018803 Q9R0N4 SYT10_MOUSE Syt10 uc007xhi.1 uc007xhi.2 uc007xhi.3 Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb (PubMed:21496647). Exocytosis of IGF1 is required for sensory perception of smell (PubMed:21496647). Not involved in Ca(2+)- dependent synaptic vesicle exocytosis (PubMed:21496647). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. ; Homodimer; disulfide-linked via the cysteine motif (PubMed:10531343). Can also form heterodimers with SYT3, SYT6, SYT7 and SYT9 (PubMed:10531343, PubMed:10531344, PubMed:10871604). Q9R0N4; Q9R0N4: Syt10; NbExp=2; IntAct=EBI-5239459, EBI-5239459; Q9R0N4; O35681: Syt3; NbExp=2; IntAct=EBI-5239459, EBI-457995; Q9R0N4; Q9R0N8: Syt6; NbExp=2; IntAct=EBI-5239459, EBI-5239378; Q9R0N4; Q9R0N9: Syt9; NbExp=2; IntAct=EBI-5239459, EBI-458006; Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein Note=Localizes to neuronal vesicles containing IGF1 that are not enriched at synapses (PubMed:21496647, PubMed:23345244). Does not colocalize with synaptic vesicles or with the Golgi apparatus (PubMed:21496647, PubMed:23345244). Highly expressed in the olfactory bulb. The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. Impaired food-finding behaviors due to defects in sensory perception of smell. Decreased number of olfactory bulb synapses in the external plexiform layer, but not the glomerular layer, of the olfactory bulb. The size and dendritic arborization of olfactory bulb neurons are decreased, but not the synapse density per dendritic length. Defects are due to impaired exocytosis of IGF1 in neurons of the olfactory bulb. Belongs to the synaptotagmin family. SNARE binding phosphatidylserine binding calcium ion binding protein binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding plasma membrane exocytosis chemical synaptic transmission sensory perception of smell regulation of dopamine secretion membrane integral component of membrane vesicle-mediated transport calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis syntaxin binding clathrin binding transport vesicle membrane cytoplasmic vesicle identical protein binding protein homodimerization activity positive regulation of calcium ion-dependent exocytosis metal ion binding protein heterodimerization activity exocytic vesicle cellular response to calcium ion presynapse synaptic vesicle exocytosis uc007xhi.1 uc007xhi.2 uc007xhi.3 
ENSMUST00000029444.13 Trim33 ENSMUST00000029444.13 tripartite motif-containing 33, transcript variant 1 (from RefSeq NM_053170.3) E9QP19 E9QP19_MOUSE ENSMUST00000029444.1 ENSMUST00000029444.10 ENSMUST00000029444.11 ENSMUST00000029444.12 ENSMUST00000029444.2 ENSMUST00000029444.3 ENSMUST00000029444.4 ENSMUST00000029444.5 ENSMUST00000029444.6 ENSMUST00000029444.7 ENSMUST00000029444.8 ENSMUST00000029444.9 NM_053170 Trim33 uc008qsv.1 uc008qsv.2 uc008qsv.3 uc008qsv.4 nucleus zinc ion binding protein ubiquitination regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway metal ion binding co-SMAD binding R-SMAD binding uc008qsv.1 uc008qsv.2 uc008qsv.3 uc008qsv.4 
ENSMUST00000029445.13 Nras ENSMUST00000029445.13 neuroblastoma ras oncogene, transcript variant 8 (from RefSeq NR_177084.1) ENSMUST00000029445.1 ENSMUST00000029445.10 ENSMUST00000029445.11 ENSMUST00000029445.12 ENSMUST00000029445.2 ENSMUST00000029445.3 ENSMUST00000029445.4 ENSMUST00000029445.5 ENSMUST00000029445.6 ENSMUST00000029445.7 ENSMUST00000029445.8 ENSMUST00000029445.9 NR_177084 Nras Q9D091 Q9D091_MOUSE uc008qsm.1 uc008qsm.2 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Golgi apparatus membrane ; Lipid-anchor Membrane ; Lipid-anchor nucleotide binding positive regulation of endothelial cell proliferation GTPase activity GTP binding Golgi apparatus signal transduction Ras protein signal transduction membrane macromolecular complex binding uc008qsm.1 uc008qsm.2 
ENSMUST00000029446.13 Csde1 ENSMUST00000029446.13 cold shock domain containing E1, RNA binding, transcript variant 1 (from RefSeq NM_144901.4) CSDE1_MOUSE Csde1 D3Jfr1 ENSMUST00000029446.1 ENSMUST00000029446.10 ENSMUST00000029446.11 ENSMUST00000029446.12 ENSMUST00000029446.2 ENSMUST00000029446.3 ENSMUST00000029446.4 ENSMUST00000029446.5 ENSMUST00000029446.6 ENSMUST00000029446.7 ENSMUST00000029446.8 ENSMUST00000029446.9 NM_144901 Q91W50 uc008qsg.1 uc008qsg.2 uc008qsg.3 uc008qsg.4 uc008qsg.5 RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules. Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with STRAP. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct and RNA-independent. Interacts with EIF4ENIF1/4E-T. Cytoplasm Cytoplasm, Stress granule Cytoplasm, P- body nucleic acid binding RNA binding cytoplasm mitochondrial inner membrane Golgi apparatus cytosol plasma membrane CRD-mediated mRNA stability complex nuclear-transcribed mRNA catabolic process, no-go decay uc008qsg.1 uc008qsg.2 uc008qsg.3 uc008qsg.4 uc008qsg.5 
ENSMUST00000029447.12 Sike1 ENSMUST00000029447.12 suppressor of IKBKE 1 (from RefSeq NM_025679.3) ENSMUST00000029447.1 ENSMUST00000029447.10 ENSMUST00000029447.11 ENSMUST00000029447.2 ENSMUST00000029447.3 ENSMUST00000029447.4 ENSMUST00000029447.5 ENSMUST00000029447.6 ENSMUST00000029447.7 ENSMUST00000029447.8 ENSMUST00000029447.9 NM_025679 Q8CBP5 Q9CPR7 SIKE1_MOUSE uc008qsf.1 uc008qsf.2 uc008qsf.3 Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF- kappa-B activation pathways (By similarity). Interacts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viral infection or TLR3 stimulation. Interacts with CDC42BPB. Cytoplasm Belongs to the SIKE family. cytoplasm biological_process Rho GTPase binding protein kinase binding uc008qsf.1 uc008qsf.2 uc008qsf.3 
ENSMUST00000029448.11 Sycp1 ENSMUST00000029448.11 synaptonemal complex protein 1 (from RefSeq NM_011516.2) B2RQK2 E9QP17 ENSMUST00000029448.1 ENSMUST00000029448.10 ENSMUST00000029448.2 ENSMUST00000029448.3 ENSMUST00000029448.4 ENSMUST00000029448.5 ENSMUST00000029448.6 ENSMUST00000029448.7 ENSMUST00000029448.8 ENSMUST00000029448.9 NM_011516 O09205 P70192 Q62209 Q62329 SYCP1_MOUSE Scp1 Sycp1 uc008qrz.1 uc008qrz.2 uc008qrz.3 Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase (PubMed:16717126). Required for normal assembly of the central element of the synaptonemal complexes (PubMed:15937223). Required for normal centromere pairing during meiosis (PubMed:22761579). Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility (PubMed:15937223). Structural component of synaptonemal complexes (PubMed:15937223, PubMed:16717126, PubMed:22761579). Homotetramer that consists of an N-terminal four-helical bundle that bifurcates into two elongated C-terminal dimeric coiled coils. This tetrameric building block potentially self-assembles into a supramolecular zipper-like lattice to mediate meiotic chromosome synapsis. Self-assembly is likely initiated by local proton density at chromosome axis, which is predicted to trigger antiparallel back to back assembly of adjacent C- terminal ends into tetrameric structures that anchor to chromosomal DNA. Then the N-terminal ends are predicted to undergo cooperative antiparallel head to head assembly at the midline of synaptonemal complexes central element to form a zipper-like lattice between properly aligned homologous chromosomes (By similarity). The nascent synapsis generated by SYCP1 is stabilized through interaction with central element proteins SYCE1 and SYCE2 (PubMed:15944401, PubMed:16968740). Forms a complex with EWSR1, PRDM9, SYCP3 and REC8; complex formation is dependent of phosphorylated form of REC8 and requires PRDM9 bound to hotspot DNA; EWSR1 joins PRDM9 with the chromosomal axis through REC8 (PubMed:27932493). Interacts with SPO16 (PubMed:30949703). Nucleus Chromosome romosome, centromere Note=In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Its N- terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex (By similarity). Only rarely detected at centromeres during leptotene and zygotene. Detected at centromeres during mid-diplotene, when it is no longer present along chromosome arms. No longer detected at centromeres at later stages of meiosis (PubMed:22761579). Detected in testis (PubMed:15937223). Detected in spermatocytes (at protein level) (PubMed:22761579). The molecule is in a coiled coil structure that is formed by 4 polypeptide chains. The N-terminal region exhibits a prominent seven- residues periodicity. Mice appear generally healthy, but display complete sterility, due to defective meiosis during germ cell development. Ovaries and testes from mutant mice have strongly reduced weight relative to wild-type. Ovaries display an absence of growing follicles and oocytes. Testes show a complete lack of spermatids and spermatozoa. Synaptonemal complexes from mutant spermatocytes form normal axial elements, but lack the central element; chromosomes do not synapse properly, cross-overs are rare, and DNA repair after meiotic double-strand breaks is impaired. Sequence=AAA64514.1; Type=Erroneous initiation; Evidence=; meiotic DNA repair synthesis chromosome, centromeric region condensed nuclear chromosome synaptonemal complex lateral element central element transverse filament male germ cell nucleus DNA binding double-stranded DNA binding protein binding nucleus nucleoplasm chromosome cell cycle synapsis synaptonemal complex assembly reciprocal meiotic recombination spermatogenesis regulation of protein localization sperm chromatin condensation chiasma assembly protein homotetramerization cell division meiotic cell cycle lateral element assembly uc008qrz.1 uc008qrz.2 uc008qrz.3 
ENSMUST00000029451.12 Tspan2 ENSMUST00000029451.12 tetraspanin 2, transcript variant 1 (from RefSeq NM_027533.3) ENSMUST00000029451.1 ENSMUST00000029451.10 ENSMUST00000029451.11 ENSMUST00000029451.2 ENSMUST00000029451.3 ENSMUST00000029451.4 ENSMUST00000029451.5 ENSMUST00000029451.6 ENSMUST00000029451.7 ENSMUST00000029451.8 ENSMUST00000029451.9 NM_027533 Q543K4 Q922J6 Q9D397 TSN2_MOUSE uc008qrw.1 uc008qrw.2 uc008qrw.3 uc008qrw.4 May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath. Membrane ; Multi-pass membrane protein Belongs to the tetraspanin (TM4SF) family. molecular_function plasma membrane integral component of plasma membrane inflammatory response brain development astrocyte development microglia development membrane integral component of membrane myelination myelin sheath oligodendrocyte differentiation axon development uc008qrw.1 uc008qrw.2 uc008qrw.3 uc008qrw.4 
ENSMUST00000029453.13 Vangl1 ENSMUST00000029453.13 VANGL planar cell polarity 1 (from RefSeq NM_177545.5) B2RRP5 ENSMUST00000029453.1 ENSMUST00000029453.10 ENSMUST00000029453.11 ENSMUST00000029453.12 ENSMUST00000029453.2 ENSMUST00000029453.3 ENSMUST00000029453.4 ENSMUST00000029453.5 ENSMUST00000029453.6 ENSMUST00000029453.7 ENSMUST00000029453.8 ENSMUST00000029453.9 Lpp2 NM_177545 Q80Z96 Q8QZT3 VANG1_MOUSE uc008qrs.1 uc008qrs.2 uc008qrs.3 uc008qrs.4 uc008qrs.5 Heterodimer with Vangl2. Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Q80Z96; P51141: Dvl1; NbExp=2; IntAct=EBI-1750708, EBI-1538407; Q80Z96; Q60838: Dvl2; NbExp=4; IntAct=EBI-1750708, EBI-641940; Q80Z96; Q61062: Dvl3; NbExp=2; IntAct=EBI-1750708, EBI-1538450; Q80Z96; P31016: Dlg4; Xeno; NbExp=4; IntAct=EBI-1750708, EBI-375655; Cell membrane ; Multi-pass membrane protein Belongs to the Vang family. protein binding plasma membrane multicellular organism development membrane integral component of membrane lateral plasma membrane pigmentation uc008qrs.1 uc008qrs.2 uc008qrs.3 uc008qrs.4 uc008qrs.5 
ENSMUST00000029454.12 Casq2 ENSMUST00000029454.12 calsequestrin 2, transcript variant 2 (from RefSeq NM_009814.4) CASQ2_MOUSE ENSMUST00000029454.1 ENSMUST00000029454.10 ENSMUST00000029454.11 ENSMUST00000029454.2 ENSMUST00000029454.3 ENSMUST00000029454.4 ENSMUST00000029454.5 ENSMUST00000029454.6 ENSMUST00000029454.7 ENSMUST00000029454.8 ENSMUST00000029454.9 NM_009814 O09161 O88505 Q56A03 uc008qrr.1 uc008qrr.2 uc008qrr.3 uc008qrr.4 uc008qrr.5 uc008qrr.6 Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. Monomer, homodimer and homooligomer. Mostly monomeric in the absence of calcium. Forms higher oligomers in a calcium-dependent manner. Dimers associate to form tetramers, that then form linear homomer chains. Interacts with ASPH and TRDN (By similarity). Sarcoplasmic reticulum lumen Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells. Detected in heart (at protein level). Detected in heart. Phosphorylation in the C-terminus moderately increases calcium buffering capacity. N-glycosylated. Mutant mice are born at the expected Mendelian rate, are viable and display normal sarcoplasmic calcium release and normal heart function under basal conditions, but have a slower heart rate. Mutant mice are subject to polymorphic arrhythmia after exercise and to catecholaminergic ventricular arrhythmia, and their myocytes show increased Ca(2+) release in response to isoproterenol. Besides, the volume of the junctional sarcoplasmic reticulum is increased, and it seems to lack visible content. Belongs to the calsequestrin family. regulation of heart rate protein kinase C binding calcium ion binding cytoplasm regulation of muscle contraction regulation of cell communication by electrical coupling regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion sarcoplasmic reticulum Z disc junctional membrane complex sarcoplasmic reticulum lumen protein homodimerization activity negative regulation of potassium ion transport sarcomere organization metal ion binding calcium-dependent protein binding sequestering of calcium ion protein polymerization cardiac muscle contraction regulation of membrane repolarization negative regulation of ryanodine-sensitive calcium-release channel activity cellular response to caffeine regulation of cardiac muscle cell contraction negative regulation of potassium ion transmembrane transporter activity uc008qrr.1 uc008qrr.2 uc008qrr.3 uc008qrr.4 uc008qrr.5 uc008qrr.6 
ENSMUST00000029456.5 Cd2 ENSMUST00000029456.5 CD2 antigen (from RefSeq NM_013486.2) Cd2 ENSMUST00000029456.1 ENSMUST00000029456.2 ENSMUST00000029456.3 ENSMUST00000029456.4 NM_013486 Q549Q4 Q549Q4_MOUSE uc008qrf.1 uc008qrf.2 uc008qrf.3 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein receptor binding cell adhesion external side of plasma membrane cell surface membrane integral component of membrane positive regulation of tumor necrosis factor production heterotypic cell-cell adhesion positive regulation of interferon-gamma secretion positive regulation of interleukin-8 secretion uc008qrf.1 uc008qrf.2 uc008qrf.3 
ENSMUST00000029459.10 Gdap2 ENSMUST00000029459.10 ganglioside-induced differentiation-associated-protein 2, transcript variant 8 (from RefSeq NR_176950.1) ENSMUST00000029459.1 ENSMUST00000029459.2 ENSMUST00000029459.3 ENSMUST00000029459.4 ENSMUST00000029459.5 ENSMUST00000029459.6 ENSMUST00000029459.7 ENSMUST00000029459.8 ENSMUST00000029459.9 GDAP2_MOUSE NR_176950 O88742 Q8C468 Q9DBL2 uc008qqr.1 uc008qqr.2 uc008qqr.3 uc008qqr.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DBL2-1; Sequence=Displayed; Name=2; IsoId=Q9DBL2-2; Sequence=VSP_033187; Expressed at high levels in brain and testis, and at low levels in liver and kidney. In the brain, expression starts at 12 dpc and increases until adulthood. By differentiation in neurons. Belongs to the GDAP2 family. Sequence=CAA76894.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; Sequence=CAA76894.1; Type=Frameshift; Evidence=; molecular_function response to retinoic acid uc008qqr.1 uc008qqr.2 uc008qqr.3 uc008qqr.4 
ENSMUST00000029462.10 Tbx15 ENSMUST00000029462.10 T-box 15, transcript variant 1 (from RefSeq NM_009323.3) ENSMUST00000029462.1 ENSMUST00000029462.2 ENSMUST00000029462.3 ENSMUST00000029462.4 ENSMUST00000029462.5 ENSMUST00000029462.6 ENSMUST00000029462.7 ENSMUST00000029462.8 ENSMUST00000029462.9 NM_009323 O54840 O70306 Q5GBG1 TBX15_MOUSE Tbx14 Tbx8 uc008qql.1 uc008qql.2 uc008qql.3 Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes. Can form a heterodimer with TBX18. Nucleus Expressed during limb development, first in the mesenchyme of the early limb bud, then during early endochondral bone development in prehypertrophic chondrocytes of cartilaginous templates. Expression is also found in mesenchymal precursor cells and prehypertrophic chondrocytes, respectively, during development of skeletal elements of the vertebral column and the head. Mice show a general reduction of bone size and changes of bone shape. In the forelimb skeleton, the scapula lacks the central region of the blade. Cartilaginous templates are already reduced in size and show a transient delay in ossification in mutant embryos. Mice show a significantly reduced proliferation of prehypertrophic chondrocytes as well as of mesenchymal precursor cells. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cell fate specification DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis Tle3-Aes complex uc008qql.1 uc008qql.2 uc008qql.3 
ENSMUST00000029463.13 Hsd3b6 ENSMUST00000029463.13 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 (from RefSeq NM_013821.3) 3BHS6_MOUSE ENSMUST00000029463.1 ENSMUST00000029463.10 ENSMUST00000029463.11 ENSMUST00000029463.12 ENSMUST00000029463.2 ENSMUST00000029463.3 ENSMUST00000029463.4 ENSMUST00000029463.5 ENSMUST00000029463.6 ENSMUST00000029463.7 ENSMUST00000029463.8 ENSMUST00000029463.9 NM_013821 O35469 Q3UQN7 uc012cuq.1 uc012cuq.2 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. May be involved in local production of progesterone. Reaction=a 3beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)- steroid + H(+) + NADH; Xref=Rhea:RHEA:24076, ChEBI:CHEBI:1722, ChEBI:CHEBI:15378, ChEBI:CHEBI:47907, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.145; Reaction=a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid; Xref=Rhea:RHEA:14709, ChEBI:CHEBI:47907, ChEBI:CHEBI:47909; EC=5.3.3.1; Lipid metabolism; steroid biosynthesis. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Expressed in skin and testis. Earliest isoform to be expressed during embryogenesis in cells of embryonic origin at 7 and 9.5 dpc, and is the major isoform expressed in uterine tissue at the time of implantation (4.5 dpc) and continues to be expressed in uterine tissue at 6.5, 7.5 and 9.5 dpc. It is expressed in giant trophoblasts at 9.5 dpc and is expressed in the placenta through 15.5 dpc. Belongs to the 3-beta-HSD family. catalytic activity 3-beta-hydroxy-delta5-steroid dehydrogenase activity steroid delta-isomerase activity mitochondrion mitochondrial inner membrane mitochondrial intermembrane space endoplasmic reticulum endoplasmic reticulum membrane steroid biosynthetic process metabolic process C21-steroid hormone metabolic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor isomerase activity hippocampus development mitochondrial membrane intracellular membrane-bounded organelle response to corticosterone oxidation-reduction process uc012cuq.1 uc012cuq.2 
ENSMUST00000029464.9 Hao2 ENSMUST00000029464.9 hydroxyacid oxidase 2 (from RefSeq NM_019545.4) ENSMUST00000029464.1 ENSMUST00000029464.2 ENSMUST00000029464.3 ENSMUST00000029464.4 ENSMUST00000029464.5 ENSMUST00000029464.6 ENSMUST00000029464.7 ENSMUST00000029464.8 HAOX2_MOUSE Hao3 Haox2 NM_019545 Q9JHS7 Q9JI00 Q9NYQ2 uc008qqj.1 uc008qqj.2 uc008qqj.3 uc008qqj.4 Oxidase that catalyzes the oxidation of medium chain hydroxyacids such as 2-hydroxyoctanoate, to the correspondong 2- oxoacids. Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation. Active in vitro with the artificial electron acceptor 2,6- dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2. Is not active on glycolate, glyoxylate, L-lactate, 2-hydroxybutanoate and 2-hydroxyhexadecanoate. Reaction=a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2; Xref=Rhea:RHEA:16789, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:35179, ChEBI:CHEBI:58123; EC=1.1.3.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16790; Evidence=; Reaction=2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2; Xref=Rhea:RHEA:67940, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:133514, ChEBI:CHEBI:176689; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67941; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Lipid metabolism; fatty acid metabolism. Homotetramer. Peroxisome Pancreas. Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Was originally thought to originate from human. catalytic activity (S)-2-hydroxy-acid oxidase activity L-lactate dehydrogenase activity mitochondrion peroxisome FMN binding oxidoreductase activity mandelate metabolic process fatty acid oxidation lactate oxidation carnosine biosynthetic process carnosine synthase activity protein homooligomerization very-long-chain-(S)-2-hydroxy-acid oxidase activity long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity medium-chain-(S)-2-hydroxy-acid oxidase activity oxidation-reduction process uc008qqj.1 uc008qqj.2 uc008qqj.3 uc008qqj.4 
ENSMUST00000029469.5 Reg4 ENSMUST00000029469.5 regenerating islet-derived family, member 4 (from RefSeq NM_026328.2) ENSMUST00000029469.1 ENSMUST00000029469.2 ENSMUST00000029469.3 ENSMUST00000029469.4 NM_026328 Q3TS25 Q9D858 Q9D8G5 REG4_MOUSE uc008qpq.1 uc008qpq.2 Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity). Secreted transmembrane signaling receptor activity extracellular region extracellular space cytoplasm heparin binding response to bacterium carbohydrate binding mannan binding uc008qpq.1 uc008qpq.2 
ENSMUST00000029476.9 Sec22b ENSMUST00000029476.9 SEC22 homolog B, vesicle trafficking protein (from RefSeq NM_011342.4) ENSMUST00000029476.1 ENSMUST00000029476.2 ENSMUST00000029476.3 ENSMUST00000029476.4 ENSMUST00000029476.5 ENSMUST00000029476.6 ENSMUST00000029476.7 ENSMUST00000029476.8 NM_011342 O08547 Q91VU3 SC22B_MOUSE Sec22l1 uc008qpk.1 uc008qpk.2 uc008qpk.3 SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. Interacts with STX17. Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B as subunit of either complex (By similarity). Interacts with the COPII Sec23/24 complex composed of SEC23A and SEC24A; recruits SEC22B into COPII-coated vesicles to allow its transport from the endoplasmic reticulum to the Golgi (By similarity). O08547; O35526: Stx1a; NbExp=4; IntAct=EBI-8400083, EBI-400878; Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane Golgi apparatus, cis-Golgi network membrane Golgi apparatus, trans-Golgi network membrane Melanosome Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. Belongs to the synaptobrevin family. Golgi membrane SNAP receptor activity protein binding endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER synaptic vesicle ER to Golgi transport vesicle membrane protein transport membrane integral component of membrane vesicle-mediated transport syntaxin binding SNARE complex endoplasmic reticulum-Golgi intermediate compartment membrane melanosome positive regulation of protein catabolic process vesicle fusion with Golgi apparatus negative regulation of autophagosome assembly uc008qpk.1 uc008qpk.2 uc008qpk.3 
ENSMUST00000029477.11 Slc25a24 ENSMUST00000029477.11 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 (from RefSeq NM_172685.3) ENSMUST00000029477.1 ENSMUST00000029477.10 ENSMUST00000029477.2 ENSMUST00000029477.3 ENSMUST00000029477.4 ENSMUST00000029477.5 ENSMUST00000029477.6 ENSMUST00000029477.7 ENSMUST00000029477.8 ENSMUST00000029477.9 NM_172685 Q3TCQ2 Q3THY3 Q7TPC2 Q8BMD8 SCMC1_MOUSE Scamc1 Slc25a24 uc008rae.1 uc008rae.2 uc008rae.3 Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide- dependent metabolic pathways. In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides. May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium- phosphate precipitates. Reaction=ATP(out) + Mg(2+)(out) + phosphate(in) = ATP(in) + Mg(2+)(in) + phosphate(out); Xref=Rhea:RHEA:65840, ChEBI:CHEBI:18420, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474; Evidence=; Reaction=ADP(out) + H(+)(out) + phosphate(in) = ADP(in) + H(+)(in) + phosphate(out); Xref=Rhea:RHEA:65844, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Reaction=AMP(out) + phosphate(in) = AMP(in) + phosphate(out); Xref=Rhea:RHEA:70259, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; Evidence=; Reaction=ATP(out) + 2 H(+)(out) + phosphate(in) = ATP(in) + 2 H(+)(in) + phosphate(out); Xref=Rhea:RHEA:72035, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474; Evidence=; Reaction=ADP(out) + dADP(in) = ADP(in) + dADP(out); Xref=Rhea:RHEA:72855, ChEBI:CHEBI:57667, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(out) + ATP(in) + H(+)(out) + Mg(2+)(in) = ADP(in) + ATP(out) + H(+)(in) + Mg(2+)(out); Xref=Rhea:RHEA:73659, ChEBI:CHEBI:15378, ChEBI:CHEBI:18420, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(out) + diphosphate(in) = ADP(in) + diphosphate(out); Xref=Rhea:RHEA:73671, ChEBI:CHEBI:33019, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(out) + dAMP(in) + H(+)(out) = ADP(in) + dAMP(out) + H(+)(in); Xref=Rhea:RHEA:73675, ChEBI:CHEBI:15378, ChEBI:CHEBI:58245, ChEBI:CHEBI:456216; Evidence=; Reaction=3'-AMP(in) + ADP(out) + H(+)(out) = 3'-AMP(out) + ADP(in) + H(+)(in); Xref=Rhea:RHEA:73679, ChEBI:CHEBI:15378, ChEBI:CHEBI:60880, ChEBI:CHEBI:456216; Evidence=; Reaction=dAMP(out) + phosphate(in) = dAMP(in) + phosphate(out); Xref=Rhea:RHEA:73687, ChEBI:CHEBI:43474, ChEBI:CHEBI:58245; Evidence=; Reaction=3'-AMP(out) + phosphate(in) = 3'-AMP(in) + phosphate(out); Xref=Rhea:RHEA:73691, ChEBI:CHEBI:43474, ChEBI:CHEBI:60880; Evidence=; Reaction=dADP(out) + H(+)(out) + phosphate(in) = dADP(in) + H(+)(in) + phosphate(out); Xref=Rhea:RHEA:73695, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57667; Evidence=; Activated by an increase in cytosolic calcium levels that induce a conformational change of the N-terminal regulatory domain, uncapping the channel and allowing transport. Inhibited by bathophenanthroline, mersalyl, p-hydroxymercuribenzoate, bromcresol purple and tannic acid. Monomer. Mitochondrion inner membrane ; Multi-pass membrane protein The regulatory N-terminal domain/NTD formed of two pairs of fused calcium-binding EF-hands, binds calcium in the mitochondrial intermembrane space and regulates the antiporter activity of the transmembrane domain/TMD. In absence of calcium, the apo form of the N- terminal domain is intrinsically disordered and binds to the transmembrane domain, inhibiting the transporter activity. Binding of calcium leads to a major conformational change and abolishes the interaction with the transmembrane domain and the inhibition of the transporter activity. The C-terminal mitochondrial carrier domain/transmembrane domain/TMD bears the transmembrane transporter activity. Linker region/H9 could directly block the transport of substrates across the transporter. Belongs to the mitochondrial carrier (TC 2.A.29) family. ATP transmembrane transporter activity calcium ion binding mitochondrion mitochondrial inner membrane mitochondrial transport regulation of cell death ATP transport membrane integral component of membrane transmembrane transporter activity cellular response to oxidative stress metal ion binding transmembrane transport cellular response to calcium ion uc008rae.1 uc008rae.2 uc008rae.3 
ENSMUST00000029478.5 Slc25a54 ENSMUST00000029478.5 solute carrier family 25, member 54 (from RefSeq NM_029054.1) 4930443G12Rik B1AUS6 B1AUS6_MOUSE ENSMUST00000029478.1 ENSMUST00000029478.2 ENSMUST00000029478.3 ENSMUST00000029478.4 NM_029054 Slc25a54 uc008rad.1 uc008rad.2 uc008rad.3 uc008rad.4 Reaction=3'-AMP(in) + ADP(out) + H(+)(out) = 3'-AMP(out) + ADP(in) + H(+)(in); Xref=Rhea:RHEA:73679, ChEBI:CHEBI:15378, ChEBI:CHEBI:60880, ChEBI:CHEBI:456216; Evidence=; Reaction=3'-AMP(out) + phosphate(in) = 3'-AMP(in) + phosphate(out); Xref=Rhea:RHEA:73691, ChEBI:CHEBI:43474, ChEBI:CHEBI:60880; Evidence=; Reaction=ADP(out) + ATP(in) + H(+)(out) + Mg(2+)(in) = ADP(in) + ATP(out) + H(+)(in) + Mg(2+)(out); Xref=Rhea:RHEA:73659, ChEBI:CHEBI:15378, ChEBI:CHEBI:18420, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(out) + H(+)(out) + phosphate(in) = ADP(in) + H(+)(in) + phosphate(out); Xref=Rhea:RHEA:65844, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(out) + dADP(in) = ADP(in) + dADP(out); Xref=Rhea:RHEA:72855, ChEBI:CHEBI:57667, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(out) + dAMP(in) + H(+)(out) = ADP(in) + dAMP(out) + H(+)(in); Xref=Rhea:RHEA:73675, ChEBI:CHEBI:15378, ChEBI:CHEBI:58245, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(out) + diphosphate(in) = ADP(in) + diphosphate(out); Xref=Rhea:RHEA:73671, ChEBI:CHEBI:33019, ChEBI:CHEBI:456216; Evidence=; Reaction=AMP(out) + phosphate(in) = AMP(in) + phosphate(out); Xref=Rhea:RHEA:70259, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; Evidence=; Reaction=ATP(out) + 2 H(+)(out) + phosphate(in) = ATP(in) + 2 H(+)(in) + phosphate(out); Xref=Rhea:RHEA:72035, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474; Evidence=; Reaction=ATP(out) + Mg(2+)(out) + phosphate(in) = ATP(in) + Mg(2+)(in) + phosphate(out); Xref=Rhea:RHEA:65840, ChEBI:CHEBI:18420, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474; Evidence=; Reaction=dADP(out) + H(+)(out) + phosphate(in) = dADP(in) + H(+)(in) + phosphate(out); Xref=Rhea:RHEA:73695, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57667; Evidence=; Reaction=dAMP(out) + phosphate(in) = dAMP(in) + phosphate(out); Xref=Rhea:RHEA:73687, ChEBI:CHEBI:43474, ChEBI:CHEBI:58245; Evidence=; Membrane ; Multi- pass membrane protein Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. ATP transmembrane transporter activity calcium ion binding mitochondrion microtubule organizing center cytosol ATP transport membrane integral component of membrane transmembrane transporter activity chromatoid body transmembrane transport uc008rad.1 uc008rad.2 uc008rad.3 uc008rad.4 
ENSMUST00000029480.9 Prpf38b ENSMUST00000029480.9 PRP38 pre-mRNA processing factor 38 (yeast) domain containing B, transcript variant 1 (from RefSeq NM_025845.3) ENSMUST00000029480.1 ENSMUST00000029480.2 ENSMUST00000029480.3 ENSMUST00000029480.4 ENSMUST00000029480.5 ENSMUST00000029480.6 ENSMUST00000029480.7 ENSMUST00000029480.8 NM_025845 PR38B_MOUSE Q80SY5 Q9CTD9 Q9CU48 Q9CUI6 uc008qzx.1 uc008qzx.2 uc008qzx.3 May be required for pre-mRNA splicing. Nucleus Belongs to the PRP38 family. nucleus spliceosomal complex mRNA processing biological_process RNA splicing precatalytic spliceosome uc008qzx.1 uc008qzx.2 uc008qzx.3 
ENSMUST00000029482.16 Gpsm2 ENSMUST00000029482.16 G-protein signalling modulator 2 (AGS3-like, C. elegans) (from RefSeq NM_029522.2) ENSMUST00000029482.1 ENSMUST00000029482.10 ENSMUST00000029482.11 ENSMUST00000029482.12 ENSMUST00000029482.13 ENSMUST00000029482.14 ENSMUST00000029482.15 ENSMUST00000029482.2 ENSMUST00000029482.3 ENSMUST00000029482.4 ENSMUST00000029482.5 ENSMUST00000029482.6 ENSMUST00000029482.7 ENSMUST00000029482.8 ENSMUST00000029482.9 GPSM2_MOUSE Lgn NM_029522 Pins Q8BLX3 Q8VDU0 uc008qzo.1 uc008qzo.2 uc008qzo.3 uc008qzo.4 Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric cell divisions (PubMed:12571286, PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (PubMed:22952234). Interacts with the dynein-dynactin complex; this interaction is inhibited in a PLK1-dependent manner (By similarity). Part of a spindle orientation complex at least composed of GNAI1, GPSM2 and NUMA1 (By similarity). Interacts with LLGL2 (By similarity). Interacts (via TPR repeat region) with INSC/inscuteable (PubMed:16094321, PubMed:21816348). Interacts (via TPR repeat region) with NUMA1 (via C- terminus); this interaction is direct, inhibited in a PLK1-dependent manner and promotes spindle pole organization (PubMed:21816348, PubMed:23318951, PubMed:23665171). INSC and NUMA1 compete for the same binding site, but INSC has higher affinity and can displace NUMA1 (in vitro) (PubMed:21816348). Interacts with GNAI2 (By similarity). Interacts (via GoLoco domains) with the GDP-bound form of GNAI1 and GNAI3; has much lower affinity for the GTP-bound form (PubMed:22952234, PubMed:23665171). Interaction with GDP-bound GNAI3 strongly enhances the affinity for NUMA1 (PubMed:23665171). Interacts (via TPR repeat region) with FRMPD1 (PubMed:23318951). INSC and FRMPD1 compete for the same binding site, but INSC has higher affinity and can displace FRMPD1 (in vitro) (PubMed:23318951). Interacts (via TPR repeat region) with FRMPD4. Identified in a complex with INSC and F2RL2/Par3 (By similarity). Interacts with TASOR (PubMed:31112734). Q8VDU0; Q62696: Dlg1; Xeno; NbExp=7; IntAct=EBI-7575403, EBI-389325; Q8VDU0; P78352: DLG4; Xeno; NbExp=7; IntAct=EBI-7575403, EBI-80389; Q8VDU0; Q14980-2: NUMA1; Xeno; NbExp=2; IntAct=EBI-7575403, EBI-10981450; Cytoplasm Cytoplasm, cell cortex Cytoplasm, cytoskeleton, spindle pole Lateral cell membrane Note=Localizes in the cytoplasm during interphase and at cell cortex during metaphase. Colocalizes with NUMA1 to mitotic spindle poles. Localized at the central and lateral cell cortex regions in a RanGTP-dependent manner (By similarity). In horizontally retinal progenitor dividing cells, localized to the lateral cortical region (PubMed:26766442). In vertically retinal progenitor dividing cells, localized at the polar cortical region (PubMed:26766442). Detected in brain and liver (at protein level). Detected in brain, spleen, liver and testis, and at lower levels in heart, lung and kidney. Enriched in the ventricular zone of the developing central nervous systems (PubMed:12571286). Expressed in proximal colon, ileum, ovary, Sertoli cells of the testis and granular cells within the cerebellum (PubMed:31112734). Each GoLoco domain can bind one GNAI3 (PubMed:22952234). In the auto-inhibited conformation, the GoLoco domains interact with the TPR repeat region (PubMed:23665171). Belongs to the GPSM family. It is uncertain whether Met-1 or Met-8 is the initiator. Sequence=AAH21308.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAL87447.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; establishment of mitotic spindle orientation nucleotide binding spindle pole G-protein alpha-subunit binding GDP-dissociation inhibitor activity protein binding cytoplasm centrosome cytosol cytoskeleton plasma membrane cell cortex cell cycle mitotic spindle organization protein C-terminus binding membrane lateral plasma membrane protein domain specific binding GTPase regulator activity Ran protein signal transduction macromolecular complex identical protein binding protein self-association regulation of catalytic activity cell division maintenance of centrosome location regulation of mitotic spindle organization dynein complex binding mitotic spindle pole lateral cell cortex cell cortex region positive regulation of protein localization to cell cortex uc008qzo.1 uc008qzo.2 uc008qzo.3 uc008qzo.4 
ENSMUST00000029485.6 Cfap276 ENSMUST00000029485.6 cilia and flagella associated protein 276 (from RefSeq NM_029314.1) CF276_MOUSE Cfap276 ENSMUST00000029485.1 ENSMUST00000029485.2 ENSMUST00000029485.3 ENSMUST00000029485.4 ENSMUST00000029485.5 NM_029314 Q9DAD0 uc008qze.1 uc008qze.2 uc008qze.3 uc008qze.4 May play an important role for the maintenance of myelin-axon integrity (PubMed:31199454). May affect intracellular Ca(2+) homeostasis. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). May play an important role for the maintenance of myelin-axon integrity (PubMed:31199454). May affect intracellular Ca(2+) homeostasis (By similarity). Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm Cytoplasm, cytoskeleton Predominantly expressed in nervous system tissues, such as the spinal cord, cerebrum, cerebellum, and sciatic nerve. molecular_function cellular_component cytoplasm cytoskeleton biological_process uc008qze.1 uc008qze.2 uc008qze.3 uc008qze.4 
ENSMUST00000029489.15 Gstm4 ENSMUST00000029489.15 glutathione S-transferase, mu 4, transcript variant 1 (from RefSeq NM_026764.3) ENSMUST00000029489.1 ENSMUST00000029489.10 ENSMUST00000029489.11 ENSMUST00000029489.12 ENSMUST00000029489.13 ENSMUST00000029489.14 ENSMUST00000029489.2 ENSMUST00000029489.3 ENSMUST00000029489.4 ENSMUST00000029489.5 ENSMUST00000029489.6 ENSMUST00000029489.7 ENSMUST00000029489.8 ENSMUST00000029489.9 GSTM4_MOUSE Gstm4 Gstm7 Gstm7-7 NM_026764 Q8R5I6 uc008qxy.1 uc008qxy.2 uc008qxy.3 uc008qxy.4 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Reaction=1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl- S-glutathione + chloride + H(+); Xref=Rhea:RHEA:51220, ChEBI:CHEBI:15378, ChEBI:CHEBI:17996, ChEBI:CHEBI:34718, ChEBI:CHEBI:57925, ChEBI:CHEBI:133977; EC=2.5.1.18; Evidence=; Reaction=(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy- (4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate; Xref=Rhea:RHEA:53508, ChEBI:CHEBI:57925, ChEBI:CHEBI:131958, ChEBI:CHEBI:137407; Evidence=; Reaction=leukotriene C4 = glutathione + leukotriene A4; Xref=Rhea:RHEA:17617, ChEBI:CHEBI:57463, ChEBI:CHEBI:57925, ChEBI:CHEBI:57973; EC=4.4.1.20; Evidence=; Homodimer. Cytoplasm Widely expressed. Belongs to the GST superfamily. Mu family. glutathione transferase activity cytoplasm cytosol glutathione metabolic process transferase activity nitrobenzene metabolic process enzyme binding xenobiotic catabolic process protein homodimerization activity glutathione binding intercellular bridge uc008qxy.1 uc008qxy.2 uc008qxy.3 uc008qxy.4 
ENSMUST00000029490.15 Ahcyl1 ENSMUST00000029490.15 S-adenosylhomocysteine hydrolase-like 1, transcript variant 1 (from RefSeq NM_145542.4) ENSMUST00000029490.1 ENSMUST00000029490.10 ENSMUST00000029490.11 ENSMUST00000029490.12 ENSMUST00000029490.13 ENSMUST00000029490.14 ENSMUST00000029490.2 ENSMUST00000029490.3 ENSMUST00000029490.4 ENSMUST00000029490.5 ENSMUST00000029490.6 ENSMUST00000029490.7 ENSMUST00000029490.8 ENSMUST00000029490.9 Irbit NM_145542 Q80SW1 SAHH2_MOUSE uc008qxj.1 uc008qxj.2 uc008qxj.3 Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (By similarity). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1- mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (By similarity). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (By similarity). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (PubMed:12525476, PubMed:23542070). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:19224921). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (PubMed:19033647, PubMed:21317537). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2. Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2- dependent calcium inhibition. May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state. Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (By similarity). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (PubMed:12525476). Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence=; Note=Binds 1 NAD(+) per subunit. ; Forms multimers (By similarity). Forms heteromultimers with AHCYL2 (via the C-terminal region) (PubMed:19220705). Interacts (when phosphorylated) with ITPR1 (when not phosphorylated); the interaction suppresses inositol 1,4,5-trisphosphate binding to ITPR1 (PubMed:23542070). Interacts with BCL2L10; this strengthens the interaction of AHCYL1 with ITPR1 (By similarity). Interacts with CFTR and SLC26A6; the interactions take place once AHCYL1 is released from ITPR1 and increase CFTR and SLC26A6 activities (PubMed:19033647, PubMed:21317537, PubMed:23542070). Interacts with RRM1; in a phosphorylation- and (dATP)-dependent manner. Interacts (via PEST domain when phosphorylated) with SLC4A4 isoform 1 but not isoform 2; the interaction increases SLC4A4 isoform 1 activity (PubMed:16769890, PubMed:19033647, PubMed:21317537). Interacts (when phosphorylated) with SLC9A3; the interaction is required for SLC9A3 apical location and activity (PubMed:19224921). Interacts (when phosphorylated) with FIP1L1; the interaction is direct and associates AHCYL1 with the CPSF complex and RNA Interacts with PAPOLA (By similarity). Interacts with ZCCHC4 (By similarity). Interacts with AHCY (By similarity). Endoplasmic reticulum Cytoplasm, cytosol Apical cell membrane ; Peripheral membrane protein Microsome Note=Associates with membranes when phosphorylated, probably through interaction with ITPR1 (PubMed:19220705). Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (By similarity). Localization to MAMs is greatly reduced under apoptotic stress conditions (By similarity). Widely expressed (at protein level). Expressed in the lateral and luminal poles of the pancreatic duct (at protein level). The PEST region is essential for the interaction with ITPR1, and, when phosphorylated, is also the RRM1-binding region. The PDZ- binding region is required for maximal interaction with ITPR1 and is also responsible for the IP3-insensitive interaction with ITPR1. Phosphorylated at Ser/Thr residues between Ser-68 and Thr-72 in the PEST region: required for interaction with dATP-bound RRM1 and ITPR1. Phosphorylation at Ser-68 by PRKD1 and CAMK4 is required for further phosphorylations by CSNK1A1. Phosphorylation is induced by oxidative stress. Probably phosphorylated by CAMK2A; phosphorylation at Ser-68 may be required for interaction with SLC9A3. Dephosphorylated in response to apoptotic stress conditions which causes translocation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes and promotes apoptosis. Belongs to the adenosylhomocysteinase family. In spite of its similarity with AHCY, which catalyzes the reversible hydrolysis of S-adenosyl-L-homocysteine to adenosine and homocysteine, recombinant AHCYL1 expressed in bacteria shows no hydrolase activity, nor does it affect the enzyme activity of AHCY. RNA binding protein binding cytoplasm endoplasmic reticulum cytosol plasma membrane mRNA polyadenylation protein export from nucleus one-carbon metabolic process positive regulation of sodium ion transport membrane apical plasma membrane regulation of mRNA 3'-end processing regulation of ion transmembrane transporter activity S-adenosylmethionine cycle angiotensin-activated signaling pathway epithelial fluid transport identical protein binding intracellular membrane-bounded organelle regulation of anion transport response to calcium ion adenosylhomocysteinase activity uc008qxj.1 uc008qxj.2 uc008qxj.3 
ENSMUST00000029502.14 Slc16a4 ENSMUST00000029502.14 solute carrier family 16 (monocarboxylic acid transporters), member 4, transcript variant 1 (from RefSeq NM_146136.3) ENSMUST00000029502.1 ENSMUST00000029502.10 ENSMUST00000029502.11 ENSMUST00000029502.12 ENSMUST00000029502.13 ENSMUST00000029502.2 ENSMUST00000029502.3 ENSMUST00000029502.4 ENSMUST00000029502.5 ENSMUST00000029502.6 ENSMUST00000029502.7 ENSMUST00000029502.8 ENSMUST00000029502.9 MOT5_MOUSE Mct5 NM_146136 Q8BLA5 Q8BWE3 Q8R0M8 Q8R157 uc008qwy.1 uc008qwy.2 uc008qwy.3 uc008qwy.4 uc008qwy.5 Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R0M8-1; Sequence=Displayed; Name=2; IsoId=Q8R0M8-2; Sequence=VSP_042511; Name=3; IsoId=Q8R0M8-3; Sequence=VSP_042510; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. plasma membrane integral component of plasma membrane monocarboxylic acid transmembrane transporter activity symporter activity monocarboxylic acid transport membrane integral component of membrane transmembrane transport uc008qwy.1 uc008qwy.2 uc008qwy.3 uc008qwy.4 uc008qwy.5 
ENSMUST00000029504.9 Cym ENSMUST00000029504.9 chymosin (from RefSeq NM_001111143.1) B7ZWD6 B7ZWD6_MOUSE Cym ENSMUST00000029504.1 ENSMUST00000029504.2 ENSMUST00000029504.3 ENSMUST00000029504.4 ENSMUST00000029504.5 ENSMUST00000029504.6 ENSMUST00000029504.7 ENSMUST00000029504.8 Gm131 NM_001111143 uc012cvu.1 uc012cvu.2 uc012cvu.3 Belongs to the peptidase A1 family. aspartic-type endopeptidase activity cellular_component proteolysis peptidase activity hydrolase activity protein catabolic process uc012cvu.1 uc012cvu.2 uc012cvu.3 
ENSMUST00000029508.11 Dennd2d ENSMUST00000029508.11 DENN domain containing 2D, transcript variant 3 (from RefSeq NM_001278941.1) DEN2D_MOUSE ENSMUST00000029508.1 ENSMUST00000029508.10 ENSMUST00000029508.2 ENSMUST00000029508.3 ENSMUST00000029508.4 ENSMUST00000029508.5 ENSMUST00000029508.6 ENSMUST00000029508.7 ENSMUST00000029508.8 ENSMUST00000029508.9 NM_001278941 Q3U028 Q91VV4 Q9D831 uc008qwa.1 uc008qwa.2 uc008qwa.3 Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VV4-1; Sequence=Displayed; Name=2; IsoId=Q91VV4-2; Sequence=VSP_019472; Sequence=BAE34027.1; Type=Erroneous initiation; Evidence=; guanyl-nucleotide exchange factor activity nucleoplasm cytoplasm cytosol Rab guanyl-nucleotide exchange factor activity uc008qwa.1 uc008qwa.2 uc008qwa.3 
ENSMUST00000029510.9 Chil6 ENSMUST00000029510.9 chitinase-like 6 (from RefSeq NM_178412.2) BC051070 Chil6 ENSMUST00000029510.1 ENSMUST00000029510.2 ENSMUST00000029510.3 ENSMUST00000029510.4 ENSMUST00000029510.5 ENSMUST00000029510.6 ENSMUST00000029510.7 ENSMUST00000029510.8 NM_178412 Q80W26 Q80W26_MOUSE uc008qvy.1 uc008qvy.2 chitinase activity extracellular region carbohydrate metabolic process chitin catabolic process chitin binding uc008qvy.1 uc008qvy.2 
ENSMUST00000029515.5 S100a11 ENSMUST00000029515.5 S100 calcium binding protein A11 (from RefSeq NM_016740.3) ENSMUST00000029515.1 ENSMUST00000029515.2 ENSMUST00000029515.3 ENSMUST00000029515.4 NM_016740 P50543 Q545S1 S100c S10AB_MOUSE uc008qfj.1 uc008qfj.2 uc008qfj.3 Facilitates the differentiation and the cornification of keratinocytes. Homodimer; disulfide-linked. Cytoplasm. Nucleus Phosphorylation at Thr-5 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation. Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins. Belongs to the S-100 family. ruffle calcium ion binding nucleus cytoplasm regulation of cell proliferation protein homodimerization activity S100 protein binding metal ion binding calcium-dependent protein binding spermatogenesis uc008qfj.1 uc008qfj.2 uc008qfj.3 
ENSMUST00000029516.3 Tchhl1 ENSMUST00000029516.3 trichohyalin-like 1 (from RefSeq NM_027762.3) ENSMUST00000029516.1 ENSMUST00000029516.2 F8VQ46 NM_027762 Q9D3P1 TCHL1_MOUSE uc008qfi.1 uc008qfi.2 Belongs to the S-100 family. molecular_function calcium ion binding transition metal ion binding uc008qfi.1 uc008qfi.2 
ENSMUST00000029520.9 Lce1m ENSMUST00000029520.9 late cornified envelope 1M, transcript variant 2 (from RefSeq NM_025420.3) ENSMUST00000029520.1 ENSMUST00000029520.2 ENSMUST00000029520.3 ENSMUST00000029520.4 ENSMUST00000029520.5 ENSMUST00000029520.6 ENSMUST00000029520.7 ENSMUST00000029520.8 Lce1m Lce5a NM_025420 Q9CR91 Q9CR91_MOUSE uc008qfa.1 uc008qfa.2 uc008qfa.3 Belongs to the LCE family. epidermis development uc008qfa.1 uc008qfa.2 uc008qfa.3 
ENSMUST00000029521.5 Crct1 ENSMUST00000029521.5 cysteine-rich C-terminal 1 (from RefSeq NM_028798.3) Crct1 ENSMUST00000029521.1 ENSMUST00000029521.2 ENSMUST00000029521.3 ENSMUST00000029521.4 NM_028798 Q6PAI5 Q6PAI5_MOUSE uc008qez.1 uc008qez.2 uc008qez.3 uc008qez.4 uc008qez.1 uc008qez.2 uc008qez.3 uc008qez.4 
ENSMUST00000029524.4 Lce1d ENSMUST00000029524.4 late cornified envelope 1D (from RefSeq NM_027137.2) ENSMUST00000029524.1 ENSMUST00000029524.2 ENSMUST00000029524.3 Lce1d NM_027137 Q9D731 Q9D731_MOUSE uc008qem.1 uc008qem.2 cornified envelope cytoplasm epidermis development perinuclear region of cytoplasm cellular response to calcium ion cell periphery uc008qem.1 uc008qem.2 
ENSMUST00000029527.6 Lce1g ENSMUST00000029527.6 late cornified envelope 1G (from RefSeq NM_025413.2) ENSMUST00000029527.1 ENSMUST00000029527.2 ENSMUST00000029527.3 ENSMUST00000029527.4 ENSMUST00000029527.5 Lce1g NM_025413 Q9D195 Q9D195_MOUSE uc008qep.1 uc008qep.2 uc008qep.3 Belongs to the LCE family. protein binding epidermis development uc008qep.1 uc008qep.2 uc008qep.3 
ENSMUST00000029530.6 Lce1a2 ENSMUST00000029530.6 late cornified envelope 1A2 (from RefSeq NM_028625.2) ENSMUST00000029530.1 ENSMUST00000029530.2 ENSMUST00000029530.3 ENSMUST00000029530.4 ENSMUST00000029530.5 Lce1a2 NM_028625 Q9D1K4 Q9D1K4_MOUSE uc008qek.1 uc008qek.2 Belongs to the LCE family. protein binding epidermis development identical protein binding uc008qek.1 uc008qek.2 
ENSMUST00000029531.4 Lce1b ENSMUST00000029531.4 late cornified envelope 1B (from RefSeq NM_026822.1) ENSMUST00000029531.1 ENSMUST00000029531.2 ENSMUST00000029531.3 Lce1b NM_026822 Q9D149 Q9D149_MOUSE Sprrl5 uc008qej.1 uc008qej.2 Belongs to the LCE family. epidermis development uc008qej.1 uc008qej.2 
ENSMUST00000029533.3 Sprr2j-ps ENSMUST00000029533.3 small proline-rich protein 2J, pseudogene (from RefSeq NR_003185.1) ENSMUST00000029533.1 ENSMUST00000029533.2 NR_003185 O70561 SPR2J_MOUSE Sprr2j uc008qdz.1 uc008qdz.2 uc008qdz.3 Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). Cytoplasm Not expressed in uterus. Belongs to the cornifin (SPRR) family. Defined as a pseudogene by MGI. Compared to other members of the family it contains a frameshift in position 20. However, proteomics data suggest the existence of the protein. cytoplasm keratinization uc008qdz.1 uc008qdz.2 uc008qdz.3 
ENSMUST00000029535.6 Lelp1 ENSMUST00000029535.6 late cornified envelope-like proline-rich 1 (from RefSeq NM_027042.1) E9QNZ8 ENSMUST00000029535.1 ENSMUST00000029535.2 ENSMUST00000029535.3 ENSMUST00000029535.4 ENSMUST00000029535.5 LELP1_MOUSE NM_027042 Q9DAE3 uc008qdn.1 uc008qdn.2 uc008qdn.3 uc008qdn.4 Belongs to the cornifin (SPRR) family. uc008qdn.1 uc008qdn.2 uc008qdn.3 uc008qdn.4 
ENSMUST00000029540.13 Npr1 ENSMUST00000029540.13 natriuretic peptide receptor 1 (from RefSeq NM_008727.5) ENSMUST00000029540.1 ENSMUST00000029540.10 ENSMUST00000029540.11 ENSMUST00000029540.12 ENSMUST00000029540.2 ENSMUST00000029540.3 ENSMUST00000029540.4 ENSMUST00000029540.5 ENSMUST00000029540.6 ENSMUST00000029540.7 ENSMUST00000029540.8 ENSMUST00000029540.9 NM_008727 Npr1 Q2TAY4 Q2TAY4_MOUSE uc008qcg.1 uc008qcg.2 uc008qcg.3 Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2; Evidence=; Membrane ; Single- pass type I membrane protein Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding guanylate cyclase activity protein kinase activity ATP binding plasma membrane cGMP biosynthetic process protein phosphorylation cell surface receptor signaling pathway receptor guanylyl cyclase signaling pathway cyclic nucleotide biosynthetic process positive regulation of cGMP-mediated signaling membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity natriuretic peptide receptor activity peptide hormone binding protein kinase binding cGMP-mediated signaling intracellular signal transduction dopamine metabolic process hormone binding receptor complex negative regulation of smooth muscle cell proliferation uc008qcg.1 uc008qcg.2 uc008qcg.3 
ENSMUST00000029541.12 Slc27a3 ENSMUST00000029541.12 solute carrier family 27 (fatty acid transporter), member 3, transcript variant 1 (from RefSeq NM_011988.4) ENSMUST00000029541.1 ENSMUST00000029541.10 ENSMUST00000029541.11 ENSMUST00000029541.2 ENSMUST00000029541.3 ENSMUST00000029541.4 ENSMUST00000029541.5 ENSMUST00000029541.6 ENSMUST00000029541.7 ENSMUST00000029541.8 ENSMUST00000029541.9 G3X8Y7 G3X8Y7_MOUSE NM_011988 Slc27a3 uc008qcc.1 uc008qcc.2 uc008qcc.3 uc008qcc.4 uc008qcc.5 Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616, ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640; Evidence=; Reaction=a fatty acid(in) = a fatty acid(out); Xref=Rhea:RHEA:38879, ChEBI:CHEBI:28868; Evidence=; Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537; Evidence=; Belongs to the ATP-dependent AMP-binding enzyme family. long-chain fatty acid metabolic process catalytic activity long-chain fatty acid-CoA ligase activity endoplasmic reticulum integral component of membrane very long-chain fatty acid-CoA ligase activity uc008qcc.1 uc008qcc.2 uc008qcc.3 uc008qcc.4 uc008qcc.5 
ENSMUST00000029542.12 Ints3 ENSMUST00000029542.12 integrator complex subunit 3, transcript variant 2 (from RefSeq NM_178876.4) A0A4X0 A0A4X3 ENSMUST00000029542.1 ENSMUST00000029542.10 ENSMUST00000029542.11 ENSMUST00000029542.2 ENSMUST00000029542.3 ENSMUST00000029542.4 ENSMUST00000029542.5 ENSMUST00000029542.6 ENSMUST00000029542.7 ENSMUST00000029542.8 ENSMUST00000029542.9 INT3_MOUSE NM_178876 Q7TPD0 Q99LK7 uc008qce.1 uc008qce.2 uc008qce.3 uc008qce.4 Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS- A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Interacts with SOSS-B1/NABP2, SOSS-B2/NABP1 and SOSS-C/INIP; the interaction is direct. Interacts with NBN/NBS1. Nucleus Cytoplasm Note=Localizes to nuclear foci following DNA damage. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TPD0-1; Sequence=Displayed; Name=2; IsoId=Q7TPD0-2; Sequence=VSP_038133, VSP_038134; Belongs to the Integrator subunit 3 family. Sequence=BAC31492.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleus nucleolus cytoplasm DNA repair cellular response to DNA damage stimulus mitotic cell cycle checkpoint response to ionizing radiation snRNA processing integrator complex SOSS complex uc008qce.1 uc008qce.2 uc008qce.3 uc008qce.4 
ENSMUST00000029545.15 Crtc2 ENSMUST00000029545.15 CREB regulated transcription coactivator 2, transcript variant 1 (from RefSeq NM_028881.4) CRTC2_MOUSE ENSMUST00000029545.1 ENSMUST00000029545.10 ENSMUST00000029545.11 ENSMUST00000029545.12 ENSMUST00000029545.13 ENSMUST00000029545.14 ENSMUST00000029545.2 ENSMUST00000029545.3 ENSMUST00000029545.4 ENSMUST00000029545.5 ENSMUST00000029545.6 ENSMUST00000029545.7 ENSMUST00000029545.8 ENSMUST00000029545.9 NM_028881 Q3TA52 Q3U182 Q8BH09 Torc2 uc008qbt.1 uc008qbt.2 uc008qbt.3 uc008qbt.4 Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Interacts with SIK2 (By similarity). Interacts with 14-3-3 proteins, YWHAB and YWHAG (PubMed:28235073). Interacts (probably when phosphorylated at Ser-171) with YWHAE (PubMed:30611118). Interacts with calmodulin-dependent catalytic subunit PPP3CA/calcineurin A (PubMed:30611118). Interaction with COP1 mediates nuclear export and degradation of CRTC2 (PubMed:17805301). Q3U182; F6VAN0: Atf6; NbExp=2; IntAct=EBI-8018890, EBI-6171558; Q3U182; Q9R1A8: Cop1; NbExp=3; IntAct=EBI-8018890, EBI-15656898; Q3U182; P63328: Ppp3ca; NbExp=2; IntAct=EBI-8018890, EBI-397208; Q3U182; P18850: ATF6; Xeno; NbExp=2; IntAct=EBI-8018890, EBI-852157; Q3U182; P29994-1: Itpr1; Xeno; NbExp=2; IntAct=EBI-8018890, EBI-15683709; Cytoplasm cleus te=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein (By similarity). In response to cAMP levels and glucagon, relocated to the nucleus (PubMed:16148943). Expressed in the suprachiasmatic nucleus (SCN) of the brain. Phosphorylation/dephosphorylation states of Ser-171 are required for regulating transduction of CREB activity (PubMed:29211348). CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site (PubMed:29211348). This primary site of phosphorylation, is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs (SIK1 and SIK2) by LKB1 (By similarity). Following adenylyl cyclase activation, dephosphorylated at Ser-171 by PPP3CA/calcineurin A resulting in CRTC2 dissociation from 14-3-3 proteins and PPP3CA (PubMed:30611118). Phosphorylation at Ser- 275 by MARK2 is induced under low glucose conditions and dephosphorylated in response to glucose influx (By similarity). Both insulin and AMPK increase this phosphorylation of CRTC2 while glucagon suppresses it (By similarity). Phosphorylation at Ser-275 promotes interaction with 14-3-3 proteins and translocation to the cytoplasm (By similarity). Asymmetric dimethylation of arginine resisues by PRMT6 enhances the association of CRTC2 with CREB on the promoters of gluconeogenic genes. Belongs to the TORC family. chromatin binding protein binding nucleus nucleoplasm cytoplasm gluconeogenesis cAMP response element binding protein binding positive regulation of CREB transcription factor activity glucose homeostasis histone H3-K9 acetylation positive regulation of transcription from RNA polymerase II promoter protein homotetramerization toxin transport uc008qbt.1 uc008qbt.2 uc008qbt.3 uc008qbt.4 
ENSMUST00000029546.15 Jtb ENSMUST00000029546.15 jumping translocation breakpoint (from RefSeq NM_206924.2) ENSMUST00000029546.1 ENSMUST00000029546.10 ENSMUST00000029546.11 ENSMUST00000029546.12 ENSMUST00000029546.13 ENSMUST00000029546.14 ENSMUST00000029546.2 ENSMUST00000029546.3 ENSMUST00000029546.4 ENSMUST00000029546.5 ENSMUST00000029546.6 ENSMUST00000029546.7 ENSMUST00000029546.8 ENSMUST00000029546.9 Jtb NM_206924 Q542D4 Q542D4_MOUSE uc008qbo.1 uc008qbo.2 uc008qbo.3 membrane integral component of membrane uc008qbo.1 uc008qbo.2 uc008qbo.3 
ENSMUST00000029547.10 Creb3l4 ENSMUST00000029547.10 cAMP responsive element binding protein 3-like 4, transcript variant 1 (from RefSeq NM_030080.3) Atce1 CR3L4_MOUSE ENSMUST00000029547.1 ENSMUST00000029547.2 ENSMUST00000029547.3 ENSMUST00000029547.4 ENSMUST00000029547.5 ENSMUST00000029547.6 ENSMUST00000029547.7 ENSMUST00000029547.8 ENSMUST00000029547.9 Jal NM_030080 Q9D2A5 Q9DAE0 Tisp40 uc008qbr.1 uc008qbr.2 uc008qbr.3 uc008qbr.4 This gene encodes a CREB (cyclic AMP-responsive element-binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein may play a role in adiposity and male germ cell development. Homozygous knockout mice for this gene show increased adipogenesis, elevated testicular germ cell apoptosis and defects in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Transcriptional activator that may play a role in the unfolded protein response of the testis. Proposed to be involved in spermiogenesis. May be involved in regulating the maturation of sperm head nuclei. Alternatively proposed to be a paternally delivered transcription factor that may function in early zygotic gene activation. Increases the binding of CREM isoform Tau with CRE. The CREM isoform Tau-CREB3L4 heterodimer functions through CRE but not through UPRE and may recruit HIRA to CRE to regulate histone exchange. Binds DNA as a dimer (By similarity). Forms a heterodimer with CREM isoform Tau. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane ; Single-pass type II membrane protein Note=According to PubMed:16925989 is not observed within nuclei of haploid spermatids at any spermiogenic stage. [Processed cyclic AMP-responsive element-binding protein 3-like protein 4]: Nucleus. Note=Under ER stress the cleaved N- terminal cytoplasmic domain translocates into the nucleus. Event=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=Tisp40beta; IsoId=Q9D2A5-1; Sequence=Displayed; Name=2; Synonyms=Tisp40alpha; IsoId=Q9D2A5-2; Sequence=VSP_025639; Predominantly expressed at high levels in testis with isoform 2 being the predominant isoform. Specifically expressed in postmeiotic spermatids and accumulates in the mid/late stage (at protein level). Ubiquitously expressed at low levels. Expression is very low in the prepubertal testis (2-5-, 8- and 17-day-old) but becomes abruptly induced in the postpubertal testis (29-day-old), after which expression increased (35- and 60-day-old). Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region. Creb3l4 null-deficient mice show a reduced spermatogenesis but are fertile. [Isoform 1]: Minor. [Isoform 2]: Major. Belongs to the bZIP family. ATF subfamily. According to PubMed:15938716 binds to the UPR element (UPRE) but not to CRE or the NF-kappa-B site. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. According to PubMed:11956138 and to PubMed:16925989 binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. Golgi membrane RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding inner acrosomal membrane DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol regulation of transcription, DNA-templated response to unfolded protein multicellular organism development spermatogenesis membrane integral component of membrane cell differentiation endoplasmic reticulum unfolded protein response cytoplasmic vesicle nuclear membrane cAMP response element binding positive regulation of transcription from RNA polymerase II promoter uc008qbr.1 uc008qbr.2 uc008qbr.3 uc008qbr.4 
ENSMUST00000029548.9 Nup210l ENSMUST00000029548.9 nucleoporin 210-like (from RefSeq NM_029937.2) ENSMUST00000029548.1 ENSMUST00000029548.2 ENSMUST00000029548.3 ENSMUST00000029548.4 ENSMUST00000029548.5 ENSMUST00000029548.6 ENSMUST00000029548.7 ENSMUST00000029548.8 NM_029937 P210L_MOUSE Q9D2F7 uc012css.1 uc012css.2 Membrane ; Single-pass membrane protein Belongs to the NUP210 family. Sequence=BAB31846.1; Type=Frameshift; Evidence=; molecular_function nuclear pore spermatid development membrane integral component of membrane Sertoli cell development uc012css.1 uc012css.2 
ENSMUST00000029559.7 Il6ra ENSMUST00000029559.7 interleukin 6 receptor, alpha, transcript variant 1 (from RefSeq NM_010559.3) ENSMUST00000029559.1 ENSMUST00000029559.2 ENSMUST00000029559.3 ENSMUST00000029559.4 ENSMUST00000029559.5 ENSMUST00000029559.6 IL6RA_MOUSE Il6r Il6ra NM_010559 P22272 uc008qaf.1 uc008qaf.2 uc008qaf.3 uc008qaf.4 Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. [Interleukin-6 receptor subunit alpha]: Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable). Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (PubMed:27893700). [Soluble interleukin-6 receptor subunit alpha]: Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed:11113088). The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans- signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (By similarity). In complex with IL6, is required for induction of VEGF production (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (PubMed:11113088). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (PubMed:28402851). Classic and trans-signaling are both inhibited by tocilizumab, a humanized monoclonal antibody that blocks interleukin IL6R signaling. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6 to associate with the signaling subunit IL6ST (PubMed:28265003). Interacts (via N-terminal ectodomain) with SORL1; this interaction may affect IL6-binding to IL6R, hence decrease IL6 'classic-signaling' (PubMed:28265003). [Soluble interleukin-6 receptor subunit alpha]: Also interacts with SORL1; this interaction leads to soluble IL6R internalization. May form a trimeric complex with the soluble SORL1 ectodomain and circulating IL6 receptor; this interaction might stabilize circulating IL6, hence promote IL6 'trans-signaling'. [Interleukin-6 receptor subunit alpha]: Cell membrane ; Single-pass type I membrane protein [Soluble interleukin-6 receptor subunit alpha]: Secreted Expressed by dendritic cells. [Soluble interleukin-6 receptor subunit alpha]: Detected in the cerebrospinal fluid. [Soluble interleukin-6 receptor subunit alpha]: Levels in the cerebrospinal fluid are increased in obese mice. The two fibronectin type-III-like domains contained in the C- terminal part form together a cytokine-binding domain. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. A short soluble form is also released from the membrane by proteolysis (PubMed:26876177). The sIL6R is formed by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding (PubMed:26876177). mIL6R is cleaved by the proteases ADAM10 and ADAM17 (PubMed:26876177). Glycosylated. Glycosylation is dispensable for transport, signaling, and cell-surface turnover. Glycosylation at Asn-55 is a protease-regulatory exosite. Glycosylation is required for ADAM17- mediated proteolysis. Belongs to the type I cytokine receptor family. Type 3 subfamily. cytokine receptor activity ciliary neurotrophic factor receptor activity interleukin-6 receptor activity interleukin-6 receptor binding extracellular region extracellular space interleukin-6 receptor complex positive regulation of cell proliferation external side of plasma membrane cell surface positive regulation of activation of Janus kinase activity membrane integral component of membrane apical plasma membrane cytokine-mediated signaling pathway enzyme binding cytokine binding interleukin-6 binding endocrine pancreas development positive regulation of chemokine production positive regulation of interleukin-6 production neuronal cell body membrane negative regulation of collagen biosynthetic process response to cytokine positive regulation of tyrosine phosphorylation of STAT protein protein homodimerization activity receptor complex positive regulation of MAPK cascade developmental growth positive regulation of smooth muscle cell proliferation positive regulation of peptidyl-tyrosine phosphorylation interleukin-6-mediated signaling pathway ciliary neurotrophic factor receptor complex ciliary neurotrophic factor binding ciliary neurotrophic factor-mediated signaling pathway positive regulation of glomerular mesangial cell proliferation uc008qaf.1 uc008qaf.2 uc008qaf.3 uc008qaf.4 
ENSMUST00000029562.5 Chrnb2 ENSMUST00000029562.5 cholinergic receptor nicotinic beta 2 subunit (from RefSeq NM_009602.4) ACHB2_MOUSE ENSMUST00000029562.1 ENSMUST00000029562.2 ENSMUST00000029562.3 ENSMUST00000029562.4 NM_009602 Q8BGP7 Q9ERK7 uc008qaa.1 uc008qaa.2 uc008qaa.3 uc008qaa.4 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Alpha-2/4:beta-2 nAChR complexes are proposed to exist in two subtypes: LS (low agonist sensitivity) with a (alpha- 2/4)3:(beta-2)2 and HS (high agonist sensitivity) with a (alpha- 2/4)2:(beta-2)3 stoichiometry; the subtypes differ in their subunit binding interfaces which are involved in ligand binding. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6. The heteropentamer alpha3-beta-2 interacts with alpha- cconotoxins BuIA, MII, ImI, ImII, PnIA and GID (By similarity). The heteropentamer alpha-4-beta-2 interacts with the alpha-conotoxins PnIA, GID and MII (By similarity). Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub- subfamily. action potential conditioned taste aversion response to hypoxia transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity protein binding plasma membrane integral component of plasma membrane acetylcholine-gated channel complex ion transport calcium ion transport smooth muscle contraction signal transduction chemical synaptic transmission synaptic transmission, cholinergic neuromuscular synaptic transmission visual perception sensory perception of sound learning memory locomotory behavior drug binding associative learning visual learning external side of plasma membrane regulation of dopamine secretion acetylcholine receptor activity membrane integral component of membrane sensory perception of pain vestibulocochlear nerve development optic nerve morphogenesis lateral geniculate nucleus development central nervous system projection neuron axonogenesis central nervous system neuron axonogenesis acetylcholine-gated cation-selective channel activity cell junction positive regulation of B cell proliferation regulation of synaptic transmission, dopaminergic positive regulation of synaptic transmission, dopaminergic positive regulation of dopamine secretion ion transmembrane transport response to nicotine behavioral response to nicotine social behavior regulation of dopamine metabolic process B cell activation acetylcholine binding response to cocaine regulation of circadian sleep/wake cycle, REM sleep regulation of membrane potential neuron projection plasma membrane raft regulation of circadian sleep/wake cycle, non-REM sleep synapse postsynaptic membrane response to ethanol negative regulation of action potential protein heterodimerization activity regulation of dendrite morphogenesis neurological system process cognition protein heterooligomerization membrane depolarization regulation of synapse assembly regulation of postsynaptic membrane potential excitatory postsynaptic potential synaptic transmission involved in micturition acetylcholine receptor signaling pathway cholinergic synapse integral component of presynaptic membrane integral component of postsynaptic specialization membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential response to acetylcholine regulation of synaptic vesicle exocytosis uc008qaa.1 uc008qaa.2 uc008qaa.3 uc008qaa.4 
ENSMUST00000029563.14 Adar ENSMUST00000029563.14 adenosine deaminase, RNA-specific, transcript variant 1 (from RefSeq NM_019655.4) DSRAD_MOUSE ENSMUST00000029563.1 ENSMUST00000029563.10 ENSMUST00000029563.11 ENSMUST00000029563.12 ENSMUST00000029563.13 ENSMUST00000029563.2 ENSMUST00000029563.3 ENSMUST00000029563.4 ENSMUST00000029563.5 ENSMUST00000029563.6 ENSMUST00000029563.7 ENSMUST00000029563.8 ENSMUST00000029563.9 NM_019655 O70375 Q80UZ6 Q8C222 Q99MU2 Q99MU3 Q99MU4 Q99MU7 uc008pzw.1 uc008pzw.2 uc008pzw.3 uc008pzw.4 Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure- dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site- specific editing). Its cellular RNA substrates include: bladder cancer- associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Does not affect polyomavirus replication but provides protection against virus-induced cytopathic effects. Essential for embryonic development and cell survival and plays a critical role in the maintenance of hematopoietic stem cells. Reaction=adenosine in double-stranded RNA + H(+) + H2O = inosine in double-stranded RNA + NH4(+); Xref=Rhea:RHEA:10120, Rhea:RHEA- COMP:13885, Rhea:RHEA-COMP:13886, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.37; Homodimer. Homodimerization is essential for its catalytic activity (PubMed:12618436). Isoform 5 can form heterodimers with ADARB1/ADAR2. Isoform 1 and isoform 5 (via DRBM 3 domain) interact with TNPO1. Isoform 5 (via DRBM domains) interacts with XPO5. Isoform 1 and isoform 5 can interact with UPF1 (By similarity). Isoform 1 interacts with ILF2/NF45 and ILF3/NF90 (PubMed:16055709). Binding to ILF3/NF90 up-regulates ILF3-mediated gene expression. Isoform 1 and isoform 5 interact with EIF2AK2/PKR (PubMed:17079286). [Isoform 1]: Cytoplasm. Nucleus, nucleolus. Note=Long forms starting at Met-1 are found predominantly in cytoplasm. Shuttles between the cytoplasm and nucleus. [Isoform 2]: Cytoplasm. Nucleus, nucleolus. Note=Long forms starting at Met-1 are found predominantly in cytoplasm. [Isoform 3]: Nucleus, nucleolus. Note=Short forms starting at Met-519 are found exclusively in the nucleolus. [Isoform 4]: Nucleus, nucleolus. Note=Short forms starting at Met-519 are found exclusively in the nucleolus. Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=ADAR1Lb, p150; IsoId=Q99MU3-1; Sequence=Displayed; Name=2; Synonyms=ADAR1La; IsoId=Q99MU3-2; Sequence=VSP_008875; Name=3; Synonyms=ADAR1Sa; IsoId=Q99MU3-3; Sequence=VSP_019236, VSP_008875; Name=4; Synonyms=ADAR1Sb, p80; IsoId=Q99MU3-4; Sequence=VSP_019236; Name=5; Synonyms=p110; IsoId=Q99MU3-5; Sequence=VSP_019237; Highest levels in brain and spleen. Lowest levels in liver. By inflammation. Under normal conditions, long forms starting at Met-1 are dominant. Inflammation causes selective induction of short forms starting at Met-519. The third dsRNA-binding domain (DRBM 3) contains an additional N-terminal alpha-helix that is part of a bi-partite nuclear localization signal, together with the sequence immediately C-terminal to DRBM 3. The presence of DRBM 3 is important to bring together the N- terminal and the C-terminal part of the bi-partite nuclear localization signal for import mediated by TNPO1. RNA binding interferes with nuclear import. The first Z-binding domain binds Z-DNA. Sumoylation reduces RNA-editing activity. Mice do not survive past 11.0-12.5 dpc, and embryos display widespread apoptosis, a rapidly disintegrating liver structure and severe defects in hematopoiesis. osteoblast differentiation in utero embryonic development hematopoietic progenitor cell differentiation immune system process somatic diversification of immune receptors via somatic mutation DNA binding left-handed Z-DNA binding RNA binding double-stranded RNA binding double-stranded RNA adenosine deaminase activity adenosine deaminase activity protein binding nucleus nucleoplasm nucleolus cytoplasm adenosine to inosine editing RNA processing mRNA processing protein import into nucleus protein export from nucleus tRNA-specific adenosine deaminase activity response to virus base conversion or substitution editing nuclear speck hydrolase activity erythrocyte differentiation gene silencing by RNA pre-miRNA processing production of miRNAs involved in gene silencing by miRNA miRNA loading onto RISC involved in gene silencing by miRNA response to interferon-alpha negative regulation of apoptotic process negative regulation of protein kinase activity by regulation of protein phosphorylation supraspliceosomal complex positive regulation of viral genome replication negative regulation of viral genome replication innate immune response metal ion binding defense response to virus definitive hemopoiesis negative regulation of type I interferon-mediated signaling pathway hematopoietic stem cell homeostasis cellular response to virus negative regulation of RNA interference uc008pzw.1 uc008pzw.2 uc008pzw.3 uc008pzw.4 
ENSMUST00000029564.12 Pmvk ENSMUST00000029564.12 phosphomevalonate kinase, transcript variant 1 (from RefSeq NM_026784.3) ENSMUST00000029564.1 ENSMUST00000029564.10 ENSMUST00000029564.11 ENSMUST00000029564.2 ENSMUST00000029564.3 ENSMUST00000029564.4 ENSMUST00000029564.5 ENSMUST00000029564.6 ENSMUST00000029564.7 ENSMUST00000029564.8 ENSMUST00000029564.9 NM_026784 PMVK_MOUSE Q8R021 Q9D1G2 Q9D6K3 uc008pzt.1 uc008pzt.2 uc008pzt.3 uc008pzt.4 Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites. Reaction=(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP; Xref=Rhea:RHEA:16341, ChEBI:CHEBI:30616, ChEBI:CHEBI:57557, ChEBI:CHEBI:58146, ChEBI:CHEBI:456216; EC=2.7.4.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16342; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:16343; Evidence=; Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3. Monomer. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D1G2-1; Sequence=Displayed; Name=2; IsoId=Q9D1G2-2; Sequence=VSP_007650, VSP_007651; Name=3; IsoId=Q9D1G2-3; Sequence=VSP_007649; Was originally thought to be located in the peroxisome. However, was later shown to be cytosolic. nucleotide binding phosphomevalonate kinase activity ATP binding cytoplasm peroxisome cytosol lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process steroid metabolic process cholesterol metabolic process isoprenoid biosynthetic process sterol biosynthetic process kinase activity phosphorylation transferase activity isopentenyl diphosphate biosynthetic process, mevalonate pathway response to cholesterol uc008pzt.1 uc008pzt.2 uc008pzt.3 uc008pzt.4 
ENSMUST00000029565.11 Slc50a1 ENSMUST00000029565.11 solute carrier family 50 (sugar transporter), member 1, transcript variant 1 (from RefSeq NM_009057.4) ENSMUST00000029565.1 ENSMUST00000029565.10 ENSMUST00000029565.2 ENSMUST00000029565.3 ENSMUST00000029565.4 ENSMUST00000029565.5 ENSMUST00000029565.6 ENSMUST00000029565.7 ENSMUST00000029565.8 ENSMUST00000029565.9 NM_009057 Q62275 Q9CXK4 Rag1ap1 Rga SWET1_MOUSE uc008pyn.1 uc008pyn.2 uc008pyn.3 Mediates sugar transport across membranes (By similarity). May regulate the expression of RAG1 a gene involved in V(D)J recombination. Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation. Golgi apparatus membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Note=May also localize to the endoplasmic reticulum. Expressed at high levels in lung, placenta, spleen and thymus, at intermediate levels in brain, heart, kidney and testis, and at low levels in bone marrow, liver and lymph node. Within the thymus expression is highest in non-lymphoid cells. Up-regulated in mammary gland during lactation. Belongs to the SWEET sugar transporter family. Golgi membrane Golgi apparatus plasma membrane carbohydrate transport endomembrane system membrane integral component of membrane carbohydrate transmembrane transport glucoside transport glucoside transmembrane transporter activity sugar transmembrane transporter activity uc008pyn.1 uc008pyn.2 uc008pyn.3 
ENSMUST00000029566.9 Efna1 ENSMUST00000029566.9 ephrin A1, transcript variant 1 (from RefSeq NM_010107.4) EFNA1_MOUSE ENSMUST00000029566.1 ENSMUST00000029566.2 ENSMUST00000029566.3 ENSMUST00000029566.4 ENSMUST00000029566.5 ENSMUST00000029566.6 ENSMUST00000029566.7 ENSMUST00000029566.8 Epgl1 Epl1 Lerk1 NM_010107 P52793 P97331 uc008pyo.1 uc008pyo.2 uc008pyo.3 uc008pyo.4 Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down- regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down- regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. Monomer. Homodimer. Forms heterodimers with EPHA2. Binds to the receptor tyrosine kinases EPHA2, EPHA3, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1 (By similarity). P52793; Q15375: EPHA7; Xeno; NbExp=2; IntAct=EBI-5241529, EBI-1383428; Cell membrane ; Lipid-anchor, GPI-anchor [Ephrin-A1, secreted form]: Secreted Expressed in myogenic progenitor cells. In myogenic progenitor cells, expressed during the acquisition of muscle stem cell properties, from 18.5 dpc to adulthood. Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form. N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization. Belongs to the ephrin family. negative regulation of transcription from RNA polymerase II promoter angiogenesis positive regulation of protein phosphorylation aortic valve morphogenesis mitral valve morphogenesis endocardial cushion to mesenchymal transition involved in heart valve formation protein binding extracellular region plasma membrane axon guidance negative regulation of epithelial to mesenchymal transition notochord formation membrane cell migration neuron differentiation anchored component of membrane regulation of cell adhesion mediated by integrin substrate adhesion-dependent cell spreading negative regulation of MAPK cascade positive regulation of MAPK cascade regulation of blood vessel endothelial cell migration regulation of angiogenesis anchored component of plasma membrane ephrin receptor binding ephrin receptor signaling pathway regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation regulation of axonogenesis protein stabilization negative regulation of dendritic spine morphogenesis positive regulation of protein tyrosine kinase activity negative regulation of thymocyte apoptotic process positive regulation of beta-amyloid formation positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of proteolysis involved in cellular protein catabolic process uc008pyo.1 uc008pyo.2 uc008pyo.3 uc008pyo.4 
ENSMUST00000029568.7 Tmem144 ENSMUST00000029568.7 transmembrane protein 144, transcript variant 8 (from RefSeq NR_166775.1) ENSMUST00000029568.1 ENSMUST00000029568.2 ENSMUST00000029568.3 ENSMUST00000029568.4 ENSMUST00000029568.5 ENSMUST00000029568.6 NR_166775 Q8VEH0 Q9CYC7 TM144_MOUSE uc008pnx.1 uc008pnx.2 uc008pnx.3 Membrane ; Multi-pass membrane protein Belongs to the TMEM144 family. molecular_function cellular_component biological_process carbohydrate transmembrane transporter activity membrane integral component of membrane carbohydrate transmembrane transport uc008pnx.1 uc008pnx.2 uc008pnx.3 
ENSMUST00000029569.9 Slc35a3 ENSMUST00000029569.9 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3, transcript variant 3 (from RefSeq NR_175853.1) ENSMUST00000029569.1 ENSMUST00000029569.2 ENSMUST00000029569.3 ENSMUST00000029569.4 ENSMUST00000029569.5 ENSMUST00000029569.6 ENSMUST00000029569.7 ENSMUST00000029569.8 NR_175853 Q8BRW7 Q8R1T4 S35A3_MOUSE uc008rcp.1 uc008rcp.2 uc008rcp.3 Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP (PubMed:31118275). May supply UDP-GlcNAc as substrate for Golgi- resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate (By similarity). However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter (By similarity). Reaction=UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) = UDP-N- acetyl-alpha-D-glucosamine(out) + UMP(in); Xref=Rhea:RHEA:72695, ChEBI:CHEBI:57705, ChEBI:CHEBI:57865; Evidence=; Kinetic parameters: KM=22 uM for UDP-GlcNAc ; Interacts with SLC35A2; the interaction is reduced in the presence of SLC35A4. Found in a complex with SLC35A2 and SLC35A4. Interacts with MGAT4B. Golgi apparatus membrane ; Multi-pass membrane protein O-Glcnacylation regulates the stability of SLC35A3 and the specific complex formation with MGAT4B. Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. Golgi membrane UDP-galactose transmembrane transporter activity Golgi apparatus carbohydrate transport pyrimidine nucleotide-sugar transmembrane transporter activity membrane integral component of membrane integral component of Golgi membrane UDP-galactose transmembrane transport pyrimidine nucleotide-sugar transmembrane transport UDP-N-acetylglucosamine transmembrane transport uc008rcp.1 uc008rcp.2 uc008rcp.3 
ENSMUST00000029570.9 Mfsd14a ENSMUST00000029570.9 major facilitator superfamily domain containing 14A, transcript variant 1 (from RefSeq NM_008246.3) ENSMUST00000029570.1 ENSMUST00000029570.2 ENSMUST00000029570.3 ENSMUST00000029570.4 ENSMUST00000029570.5 ENSMUST00000029570.6 ENSMUST00000029570.7 ENSMUST00000029570.8 Hiat1 MF14A_MOUSE Mfsd14a NM_008246 P70187 Q3TY74 Q9DBS0 uc008rco.1 uc008rco.2 uc008rco.3 uc008rco.4 Membrane ; Multi-pass membrane protein Expressed in various tissues. Evenly distributed throughout the neonatal brain. Belongs to the major facilitator superfamily. acrosome assembly integral component of plasma membrane spermatogenesis spermatid development spermatid nucleus differentiation membrane integral component of membrane transmembrane transporter activity sperm mitochondrion organization transmembrane transport uc008rco.1 uc008rco.2 uc008rco.3 uc008rco.4 
ENSMUST00000029573.8 Lrrc39 ENSMUST00000029573.8 leucine rich repeat containing 39, transcript variant 2 (from RefSeq NM_175413.4) ENSMUST00000029573.1 ENSMUST00000029573.2 ENSMUST00000029573.3 ENSMUST00000029573.4 ENSMUST00000029573.5 ENSMUST00000029573.6 ENSMUST00000029573.7 LRC39_MOUSE Lrrc39 NM_175413 Q8BGI7 uc008rci.1 uc008rci.2 uc008rci.3 uc008rci.4 Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart. Interacts with MYH7 (via C-terminus). Cytoplasm, myofibril, sarcomere, M line Expressed in heart and skeletal muscle. molecular_function cellular_component cytoplasm biological_process M band uc008rci.1 uc008rci.2 uc008rci.3 uc008rci.4 
ENSMUST00000029574.13 Vcam1 ENSMUST00000029574.13 vascular cell adhesion molecule 1 (from RefSeq NM_011693.3) ENSMUST00000029574.1 ENSMUST00000029574.10 ENSMUST00000029574.11 ENSMUST00000029574.12 ENSMUST00000029574.2 ENSMUST00000029574.3 ENSMUST00000029574.4 ENSMUST00000029574.5 ENSMUST00000029574.6 ENSMUST00000029574.7 ENSMUST00000029574.8 ENSMUST00000029574.9 NM_011693 Q3UPN1 Q3UPN1_MOUSE Vcam1 uc008rbx.1 uc008rbx.2 uc008rbx.3 Cell membrane ; Single-pass type I membrane protein response to hypoxia podosome acute inflammatory response chronic inflammatory response integrin binding extracellular space early endosome endoplasmic reticulum Golgi apparatus microvillus cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion cell-matrix adhesion aging response to nutrient primary amine oxidase activity amine metabolic process external side of plasma membrane cell surface response to zinc ion response to ionizing radiation membrane integral component of membrane membrane to membrane docking filopodium response to lipopolysaccharide heterotypic cell-cell adhesion response to nicotine calcium-mediated signaling using intracellular calcium source cellular response to vascular endothelial growth factor stimulus positive regulation of T cell proliferation sarcolemma apical part of cell response to ethanol cell adhesion molecule binding leukocyte tethering or rolling oxidation-reduction process cell chemotaxis innervation cardiac neuron differentiation alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex cellular response to tumor necrosis factor cell-cell adhesion cellular response to beta-amyloid uc008rbx.1 uc008rbx.2 uc008rbx.3 
ENSMUST00000029575.12 Extl2 ENSMUST00000029575.12 exostosin-like glycosyltransferase 2, transcript variant 1 (from RefSeq NM_021388.4) ENSMUST00000029575.1 ENSMUST00000029575.10 ENSMUST00000029575.11 ENSMUST00000029575.2 ENSMUST00000029575.3 ENSMUST00000029575.4 ENSMUST00000029575.5 ENSMUST00000029575.6 ENSMUST00000029575.7 ENSMUST00000029575.8 ENSMUST00000029575.9 EXTL2_MOUSE Extr2 NM_021388 Q505Q8 Q9CX90 Q9ES89 uc008rbu.1 uc008rbu.2 uc008rbu.3 uc008rbu.4 Glycosyltransferase required for the biosynthesis of heparan- sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Reaction=3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)- beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3- O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D- Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:16221, Rhea:RHEA-COMP:12573, Rhea:RHEA-COMP:12574, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:132093, ChEBI:CHEBI:132104; EC=2.4.1.223; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Kinetic parameters: KM=320 uM for UDP-GalNAc ; KM=560 uM for UDP-GlcNAc ; Endoplasmic reticulum membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 47 family. glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity glycosaminoglycan binding endoplasmic reticulum endoplasmic reticulum membrane N-acetylglucosamine metabolic process protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups UDP-N-acetylgalactosamine metabolic process manganese ion binding alpha-1,4-N-acetylgalactosaminyltransferase activity metal ion binding glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity uc008rbu.1 uc008rbu.2 uc008rbu.3 uc008rbu.4 
ENSMUST00000029587.9 Neurog2 ENSMUST00000029587.9 neurogenin 2 (from RefSeq NM_009718.4) ENSMUST00000029587.1 ENSMUST00000029587.2 ENSMUST00000029587.3 ENSMUST00000029587.4 ENSMUST00000029587.5 ENSMUST00000029587.6 ENSMUST00000029587.7 ENSMUST00000029587.8 NM_009718 Neurog2 Q6GTH9 Q6GTH9_MOUSE uc008rhi.1 uc008rhi.2 uc008rhi.3 regulation of transcription, DNA-templated neuron differentiation protein dimerization activity uc008rhi.1 uc008rhi.2 uc008rhi.3 
ENSMUST00000029588.10 Larp7 ENSMUST00000029588.10 La ribonucleoprotein 7, transcriptional regulator (from RefSeq NM_138593.2) D3Wsu161e ENSMUST00000029588.1 ENSMUST00000029588.2 ENSMUST00000029588.3 ENSMUST00000029588.4 ENSMUST00000029588.5 ENSMUST00000029588.6 ENSMUST00000029588.7 ENSMUST00000029588.8 ENSMUST00000029588.9 LARP7_MOUSE Larp7 NM_138593 Q05CL8 Q3TSC2 Q8K2Y6 Q8VDW3 Q9CSI2 Q9CSI9 Q9CUQ5 uc008rhd.1 uc008rhd.2 RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:32017896). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (By similarity). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (By similarity). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (By similarity). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017896). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017896). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017896). Binds U6 snRNAs with a 5'- CAGGG-3' sequence motif (By similarity). U6 snRNA processing is required for spermatogenesis (PubMed:32017896). Core component of the 7SK RNP complex, at least composed of 7SK RNA, LARP7, MEPCE, HEXIM1 (or HEXIM2) and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) (By similarity). Interacts with METTL16 (By similarity). Interacts with RBM7; upon genotoxic stress this interaction is enhanced, triggering the release of inactive P-TEFb complex from the core, yielding to P-TEFb complex activation (By similarity). Associates with box C/D small nucleolar ribonucleoprotein (snoRNP) complexes (PubMed:32017896). Nucleus, nucleoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q05CL8-1; Sequence=Displayed; Name=2; IsoId=Q05CL8-2; Sequence=VSP_024022, VSP_024023; Preferentially expressed in primordial germ cells (PubMed:23154982). Ubiquitously expressed in the embryo (PubMed:22865833). The xRRM domain binds the 3' end of 7SK snRNA (7SK RNA) at the top of stem-loop 4. Embryonic lethality between embryonic day 17.5 dpc and birth (PubMed:23154982). Conditional knockout mice lacking Larp7 in germline cells show defects in spermatogenesis: males are sterile, whereas all females display normal fertility (PubMed:32017896). Cells show reduced 2'-O-methylation of U6 snRNAs and defects in mRNA splicing (PubMed:32017896). Belongs to the LARP7 family. Sequence=AAH23165.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleic acid binding RNA binding nucleus nucleoplasm cytosol RNA processing negative regulation of chromatin binding germ cell proliferation positive regulation of G1/S transition of mitotic cell cycle ribonucleoprotein complex uc008rhd.1 uc008rhd.2 
ENSMUST00000029598.10 1700006A11Rik ENSMUST00000029598.10 RIKEN cDNA 1700006A11 gene, transcript variant 1 (from RefSeq NM_027939.2) 1700006A11Rik B9EHI3 B9EHI3_MOUSE ENSMUST00000029598.1 ENSMUST00000029598.2 ENSMUST00000029598.3 ENSMUST00000029598.4 ENSMUST00000029598.5 ENSMUST00000029598.6 ENSMUST00000029598.7 ENSMUST00000029598.8 ENSMUST00000029598.9 NM_027939 uc012cxd.1 uc012cxd.2 uc012cxd.3 GTPase activator activity cellular_component signal transduction positive regulation of GTPase activity uc012cxd.1 uc012cxd.2 uc012cxd.3 
ENSMUST00000029603.10 Prss12 ENSMUST00000029603.10 serine protease 12 neurotrypsin (motopsin) (from RefSeq NM_008939.2) Bssp3 ENSMUST00000029603.1 ENSMUST00000029603.2 ENSMUST00000029603.3 ENSMUST00000029603.4 ENSMUST00000029603.5 ENSMUST00000029603.6 ENSMUST00000029603.7 ENSMUST00000029603.8 ENSMUST00000029603.9 NETR_MOUSE NM_008939 O08762 uc008rfl.1 uc008rfl.2 uc008rfl.3 uc008rfl.4 Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. Secreted. Most abundant in cerebral cortex, hippocampus and amygdala. Belongs to the peptidase S1 family. serine-type endopeptidase activity scavenger receptor activity extracellular region plasma membrane proteolysis exocytosis endocytosis peptidase activity serine-type peptidase activity membrane hydrolase activity axon dendrite cytoplasmic vesicle zymogen activation synaptic cleft terminal bouton synapse uc008rfl.1 uc008rfl.2 uc008rfl.3 uc008rfl.4 
ENSMUST00000029610.9 Hadh ENSMUST00000029610.9 hydroxyacyl-Coenzyme A dehydrogenase (from RefSeq NM_008212.4) ENSMUST00000029610.1 ENSMUST00000029610.2 ENSMUST00000029610.3 ENSMUST00000029610.4 ENSMUST00000029610.5 ENSMUST00000029610.6 ENSMUST00000029610.7 ENSMUST00000029610.8 HCDH_MOUSE Hadhsc Mschad NM_008212 Q3TF75 Q3THK8 Q3UFI0 Q61425 Q8K149 Q925U9 Schad uc008rjl.1 uc008rjl.2 uc008rjl.3 uc008rjl.4 Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (By similarity). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (PubMed:20670938). Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35; Evidence=; Reaction=(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:30799, ChEBI:CHEBI:15378, ChEBI:CHEBI:57286, ChEBI:CHEBI:57316, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:31187, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62548, ChEBI:CHEBI:62616; Evidence=; Reaction=(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:31159, ChEBI:CHEBI:15378, ChEBI:CHEBI:57349, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62613; Evidence=; Lipid metabolism; fatty acid beta-oxidation. Homodimer (By similarity). Interacts with GLUD1; this interaction inhibits the activation of glutamate dehydrogenase 1 (GLUD1) (PubMed:20670938). Mitochondrion matrix Expressed in liver, kidney, brain, and pancreatic islets. Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5. Deficient mice display reduced levels of plasma glucose, elevated plasma insulin levels, increased plasma 3- hydroxybutyrylcarnitine and increased urinary 3-hydroxyglutarate. Islets isolated from knockout mice have increased amino acid-stimulated insulin secretion and higher sensitivity to leucine-stimulated insulin secretion. Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. Sequence=BAA06122.1; Type=Erroneous initiation; Evidence=; 3-hydroxyacyl-CoA dehydrogenase activity nucleoplasm cytoplasm mitochondrion mitochondrial inner membrane mitochondrial matrix lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation response to hormone response to activity oxidoreductase activity response to insulin response to drug negative regulation of insulin secretion oxidation-reduction process NAD+ binding uc008rjl.1 uc008rjl.2 uc008rjl.3 uc008rjl.4 
ENSMUST00000029623.11 Tlr2 ENSMUST00000029623.11 toll-like receptor 2 (from RefSeq NM_011905.3) ENSMUST00000029623.1 ENSMUST00000029623.10 ENSMUST00000029623.2 ENSMUST00000029623.3 ENSMUST00000029623.4 ENSMUST00000029623.5 ENSMUST00000029623.6 ENSMUST00000029623.7 ENSMUST00000029623.8 ENSMUST00000029623.9 G3X8Y8 G3X8Y8_MOUSE NM_011905 Tlr2 uc008ppn.1 uc008ppn.2 uc008ppn.3 uc008ppn.4 Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Cytoplasmic vesicle, phagosome membrane ; Single-pass type I membrane protein Membrane raft Membrane ; Single-pass type I membrane protein Belongs to the Toll-like receptor family. lipopolysaccharide binding beta-amyloid binding response to hypoxia microglial cell activation cell activation toll-like receptor signaling pathway response to molecule of bacterial origin cytokine secretion involved in immune response immune system process MyD88-dependent toll-like receptor signaling pathway cytoplasm Golgi apparatus plasma membrane integral component of plasma membrane leukotriene metabolic process inflammatory response signal transduction I-kappaB phosphorylation negative regulation of cell proliferation signaling pattern recognition receptor activity response to toxic substance cell surface positive regulation of gene expression membrane integral component of membrane positive regulation of Wnt signaling pathway intrinsic component of plasma membrane central nervous system myelin formation response to bacterial lipoprotein response to lipopolysaccharide response to progesterone interleukin-10 production positive regulation of chemokine production positive regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production response to insulin positive regulation of toll-like receptor signaling pathway toll-like receptor 2 signaling pathway Toll-like receptor binding Toll-like receptor 1-Toll-like receptor 2 protein complex detection of triacyl bacterial lipopeptide detection of diacyl bacterial lipopeptide triacyl lipopeptide binding identical protein binding peptidoglycan binding cell projection cell body macromolecular complex binding innate immune response membrane raft nitric oxide metabolic process protein heterodimerization activity positive regulation of oligodendrocyte differentiation regulation of cytokine secretion positive regulation of inflammatory response defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity response to fatty acid cellular response to lipoteichoic acid cellular response to interferon-gamma lipopeptide binding cellular response to diacyl bacterial lipopeptide cellular response to triacyl bacterial lipopeptide positive regulation of NIK/NF-kappaB signaling positive regulation of cellular response to macrophage colony-stimulating factor stimulus positive regulation of matrix metallopeptidase secretion positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion uc008ppn.1 uc008ppn.2 uc008ppn.3 uc008ppn.4 
ENSMUST00000029624.15 Mcub ENSMUST00000029624.15 mitochondrial calcium uniporter dominant negative beta subunit, transcript variant 1 (from RefSeq NM_025779.4) A0A9S4GQC1 A0A9S4GQC1_MOUSE ENSMUST00000029624.1 ENSMUST00000029624.10 ENSMUST00000029624.11 ENSMUST00000029624.12 ENSMUST00000029624.13 ENSMUST00000029624.14 ENSMUST00000029624.2 ENSMUST00000029624.3 ENSMUST00000029624.4 ENSMUST00000029624.5 ENSMUST00000029624.6 ENSMUST00000029624.7 ENSMUST00000029624.8 ENSMUST00000029624.9 Mcub NM_025779 uc008rir.1 uc008rir.2 uc008rir.3 Membrane ; Multi- pass membrane protein Mitochondrion inner membrane ulti-pass membrane protein Belongs to the MCU (TC 1.A.77) family. uc008rir.1 uc008rir.2 uc008rir.3 
ENSMUST00000029625.8 Sfrp2 ENSMUST00000029625.8 secreted frizzled-related protein 2 (from RefSeq NM_009144.2) ENSMUST00000029625.1 ENSMUST00000029625.2 ENSMUST00000029625.3 ENSMUST00000029625.4 ENSMUST00000029625.5 ENSMUST00000029625.6 ENSMUST00000029625.7 NM_009144 Q3UI35 Q3UI35_MOUSE Sfrp2 uc008ppl.1 uc008ppl.2 uc008ppl.3 uc008ppl.4 Belongs to the secreted frizzled-related protein (sFRP) family. Lacks conserved residue(s) required for the propagation of feature annotation. outflow tract morphogenesis cardiac left ventricle morphogenesis extracellular region extracellular space multicellular organism development response to nutrient positive regulation of cell proliferation negative regulation of cell proliferation negative regulation of epithelial to mesenchymal transition Wnt signaling pathway negative regulation of Wnt signaling pathway negative regulation of cell growth positive regulation of apoptotic process positive regulation of fat cell differentiation negative regulation of transcription, DNA-templated negative regulation of epithelial cell proliferation negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway uc008ppl.1 uc008ppl.2 uc008ppl.3 uc008ppl.4 
ENSMUST00000029626.9 Casp6 ENSMUST00000029626.9 caspase 6 (from RefSeq NM_009811.4) Casp6 ENSMUST00000029626.1 ENSMUST00000029626.2 ENSMUST00000029626.3 ENSMUST00000029626.4 ENSMUST00000029626.5 ENSMUST00000029626.6 ENSMUST00000029626.7 ENSMUST00000029626.8 NM_009811 Q3TPJ9 Q3TPJ9_MOUSE uc008riq.1 uc008riq.2 uc008riq.3 uc008riq.4 uc008riq.5 This gene encodes a member of the cysteine proteases that plays important roles in regulating apoptosis and neurodegeneration. The encoded protein is involved in the transmission of pain and axonal degeneration. Genetic deletion of this gene in mice results in the delay of axon pruning and protects from axon degeneration. [provided by RefSeq, Apr 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146363.1, AK168842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Reaction=Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.; EC=3.4.22.59; Evidence=; Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit. Nucleus Belongs to the peptidase C14A family. cysteine-type endopeptidase activity nucleoplasm cytosol proteolysis apoptotic process peptidase activity cysteine-type peptidase activity hydrolase activity epithelial cell differentiation identical protein binding cellular response to staurosporine execution phase of apoptosis cysteine-type endopeptidase activity involved in execution phase of apoptosis uc008riq.1 uc008riq.2 uc008riq.3 uc008riq.4 uc008riq.5 
ENSMUST00000029629.15 Pla2g12a ENSMUST00000029629.15 phospholipase A2, group XIIA, transcript variant 4 (from RefSeq NR_104611.1) ENSMUST00000029629.1 ENSMUST00000029629.10 ENSMUST00000029629.11 ENSMUST00000029629.12 ENSMUST00000029629.13 ENSMUST00000029629.14 ENSMUST00000029629.2 ENSMUST00000029629.3 ENSMUST00000029629.4 ENSMUST00000029629.5 ENSMUST00000029629.6 ENSMUST00000029629.7 ENSMUST00000029629.8 ENSMUST00000029629.9 NR_104611 PG12A_MOUSE Pla2g12 Q3TQC4 Q9CQR3 Q9CTL1 Q9D7L3 Q9EPR1 Q9EPR2 uc012cxt.1 uc012cxt.2 uc012cxt.3 PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Secreted. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EPR2-1; Sequence=Displayed; Name=2; IsoId=Q9EPR2-2; Sequence=VSP_004509; Belongs to the phospholipase A2 family. phospholipase A2 activity calcium ion binding extracellular region cytoplasm endoplasmic reticulum Golgi apparatus lipid metabolic process phospholipid metabolic process lipid catabolic process hydrolase activity metal ion binding arachidonic acid secretion uc012cxt.1 uc012cxt.2 uc012cxt.3 
ENSMUST00000029632.7 Lrat ENSMUST00000029632.7 lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) (from RefSeq NM_023624.4) ENSMUST00000029632.1 ENSMUST00000029632.2 ENSMUST00000029632.3 ENSMUST00000029632.4 ENSMUST00000029632.5 ENSMUST00000029632.6 LRAT_MOUSE NM_023624 Q9JI60 uc012cqv.1 uc012cqv.2 uc012cqv.3 Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (PubMed:28758396). LRAT plays a critical role in vision (By similarity). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis- retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (By similarity). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (PubMed:25416279). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol-- [retinol-binding protein] = a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]; Xref=Rhea:RHEA:17469, Rhea:RHEA-COMP:14426, Rhea:RHEA-COMP:14428, ChEBI:CHEBI:17336, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875, ChEBI:CHEBI:63410, ChEBI:CHEBI:83228; EC=2.3.1.135; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17470; Evidence=; Reaction=1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans- retinol--[retinol-binding protein] = 2-heptanoyl-sn-glycero-3- phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]; Xref=Rhea:RHEA:55320, Rhea:RHEA-COMP:14426, Rhea:RHEA- COMP:14428, ChEBI:CHEBI:17336, ChEBI:CHEBI:83228, ChEBI:CHEBI:138195, ChEBI:CHEBI:138266, ChEBI:CHEBI:138724; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55321; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans- retinol--[retinol-binding protein] = 2-octanoyl-sn-glycero-3- phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]; Xref=Rhea:RHEA:56240, Rhea:RHEA-COMP:14426, Rhea:RHEA- COMP:14428, ChEBI:CHEBI:17336, ChEBI:CHEBI:78228, ChEBI:CHEBI:83228, ChEBI:CHEBI:140082, ChEBI:CHEBI:140084; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56241; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans- retinol--[retinol-binding protein] = 2-hexadecanoyl-sn-glycero-3- phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol- binding protein]; Xref=Rhea:RHEA:56244, Rhea:RHEA-COMP:14426, Rhea:RHEA-COMP:14428, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616, ChEBI:CHEBI:72999, ChEBI:CHEBI:76078, ChEBI:CHEBI:83228; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56245; Evidence=; Reaction=1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans- retinol--[retinol-binding protein] = 2-dodecanoyl-sn-glycero-3- phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol- binding protein]; Xref=Rhea:RHEA:56248, Rhea:RHEA-COMP:14426, Rhea:RHEA-COMP:14428, ChEBI:CHEBI:17336, ChEBI:CHEBI:65211, ChEBI:CHEBI:83228, ChEBI:CHEBI:140088, ChEBI:CHEBI:140089; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56249; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans- retinol = all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero- 3-phosphocholine; Xref=Rhea:RHEA:43904, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43905; Evidence=; Inhibited by all-trans-retinyl alpha-bromoacetate and N-boc-L-biocytinyl-11-aminoundecane chloro-methyl ketone (BACMK). Kinetic parameters: KM=4.9 uM for all-trans-retinol--[retinol-binding protein] ; Cofactor metabolism; retinol metabolism. Endoplasmic reticulum membrane ; Single-pass membrane protein Rough endoplasmic reticulum Endosome, multivesicular body Cytoplasm, perinuclear region Note=Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity). Hepatic stellate cells and endothelial cells (at protein level). LRAT activity is up-regulated by dietary vitamin A (By similarity). Under conditions of vitamin A depletion, LRAT expression in the liver is induced by retinoic acid. Knockout mice are viable (PubMed:25416279). Knockout mice at one month of age show loss of nearly all cone photoreceptors in the central and ventral retina (PubMed:25416279). Surviving cone cells show severe degeneration, the dorsal retinal also exhibits a significant reduction in cone photoreceptors (PubMed:25416279). At one month of age rod photoreceptors show shorter outer segments (PubMed:25416279). Nearly all cone photoreceptors are lost by six months of age (PubMed:25416279). Remaining cone cells show disrupted structures with the majority showing abnormal cell bodies or lack of an outer segment (PubMed:25416279). Belongs to the H-rev107 family. retinoic acid binding cytoplasm endosome multivesicular body endoplasmic reticulum endoplasmic reticulum membrane rough endoplasmic reticulum 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process vitamin A metabolic process visual perception O-acyltransferase activity response to bacterium membrane integral component of membrane transferase activity transferase activity, transferring acyl groups retinol binding positive regulation of lipid transport response to retinoic acid response to vitamin A retinol metabolic process intracellular membrane-bounded organelle phosphatidylcholine-retinol O-acyltransferase activity perinuclear region of cytoplasm response to stimulus lecithin:11-cis retinol acyltransferase activity cellular response to leukemia inhibitory factor uc012cqv.1 uc012cqv.2 uc012cqv.3 
ENSMUST00000029633.5 Npy2r ENSMUST00000029633.5 neuropeptide Y receptor Y2, transcript variant 1 (from RefSeq NM_008731.4) ENSMUST00000029633.1 ENSMUST00000029633.2 ENSMUST00000029633.3 ENSMUST00000029633.4 F7C6W7 NM_008731 NPY2R_MOUSE P97295 Q8BWV1 uc033huk.1 uc033huk.2 uc033huk.3 Receptor for neuropeptide Y and peptide YY. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Sequence=BAA13050.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; peptide YY receptor activity behavioral fear response positive regulation of peptide secretion outflow tract morphogenesis cardiac left ventricle morphogenesis G-protein coupled receptor activity neuropeptide Y receptor activity plasma membrane integral component of plasma membrane cilium signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway nitric oxide mediated signal transduction aging positive regulation of cell-substrate adhesion membrane integral component of membrane negative regulation of neurological system process positive regulation of dopamine secretion negative regulation of cAMP-mediated signaling positive regulation of smooth muscle contraction positive regulation of circadian sleep/wake cycle, non-REM sleep secretion negative regulation of synaptic transmission negative regulation of secretion regulation of sensory perception of pain negative regulation of synaptic transmission, glutamatergic negative regulation of excitatory postsynaptic potential non-motile cilium negative regulation of feeding behavior uc033huk.1 uc033huk.2 uc033huk.3 
ENSMUST00000029635.14 Gucy1b1 ENSMUST00000029635.14 guanylate cyclase 1, soluble, beta 1, transcript variant 1 (from RefSeq NM_017469.4) ENSMUST00000029635.1 ENSMUST00000029635.10 ENSMUST00000029635.11 ENSMUST00000029635.12 ENSMUST00000029635.13 ENSMUST00000029635.2 ENSMUST00000029635.3 ENSMUST00000029635.4 ENSMUST00000029635.5 ENSMUST00000029635.6 ENSMUST00000029635.7 ENSMUST00000029635.8 ENSMUST00000029635.9 GCYB1_MOUSE Gucy1b3 NM_017469 O54865 uc008por.1 uc008por.2 uc008por.3 uc008por.4 Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Note=Binds 1 or 2 heme groups per heterodimer. Heme is required for responding to nitric oxide, but not for catalytic activity. ; Activated by nitric oxide in the presence of magnesium or manganese ions. The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1A1. Can also form inactive homodimers in vitro. Cytoplasm There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding adenylate cyclase activity guanylate cyclase activity GTP binding cytoplasm cGMP biosynthetic process guanylate cyclase complex, soluble cyclic nucleotide biosynthetic process lyase activity phosphorus-oxygen lyase activity cGMP-mediated signaling heme binding macromolecular complex intracellular signal transduction nitric oxide-cGMP-mediated signaling pathway ion binding metal ion binding protein heterodimerization activity cytidylate cyclase activity presynaptic active zone Hsp90 protein binding cellular response to nitric oxide presynaptic active zone cytoplasmic component glutamatergic synapse trans-synaptic signaling by nitric oxide, modulating synaptic transmission uc008por.1 uc008por.2 uc008por.3 uc008por.4 
ENSMUST00000029639.12 Snx7 ENSMUST00000029639.12 sorting nexin 7, transcript variant 1 (from RefSeq NM_029655.3) ENSMUST00000029639.1 ENSMUST00000029639.10 ENSMUST00000029639.11 ENSMUST00000029639.2 ENSMUST00000029639.3 ENSMUST00000029639.4 ENSMUST00000029639.5 ENSMUST00000029639.6 ENSMUST00000029639.7 ENSMUST00000029639.8 ENSMUST00000029639.9 F8WI30 F8WI30_MOUSE NM_029655 Snx7 uc008rdc.1 uc008rdc.2 uc008rdc.3 uc008rdc.4 Heterodimer; heterodimerizes with SNX4. Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the sorting nexin family. phosphatidylinositol binding uc008rdc.1 uc008rdc.2 uc008rdc.3 uc008rdc.4 
ENSMUST00000029642.9 1700061I17Rik ENSMUST00000029642.9 RIKEN cDNA 1700061I17 gene (from RefSeq NR_038029.1) ENSMUST00000029642.1 ENSMUST00000029642.2 ENSMUST00000029642.3 ENSMUST00000029642.4 ENSMUST00000029642.5 ENSMUST00000029642.6 ENSMUST00000029642.7 ENSMUST00000029642.8 NR_038029 uc029uok.1 uc029uok.2 uc029uok.3 uc029uok.1 uc029uok.2 uc029uok.3 
ENSMUST00000029643.15 Gar1 ENSMUST00000029643.15 GAR1 ribonucleoprotein (from RefSeq NM_026578.3) ENSMUST00000029643.1 ENSMUST00000029643.10 ENSMUST00000029643.11 ENSMUST00000029643.12 ENSMUST00000029643.13 ENSMUST00000029643.14 ENSMUST00000029643.2 ENSMUST00000029643.3 ENSMUST00000029643.4 ENSMUST00000029643.5 ENSMUST00000029643.6 ENSMUST00000029643.7 ENSMUST00000029643.8 ENSMUST00000029643.9 GAR1_MOUSE NM_026578 Nola1 Q80X93 Q8C6C5 Q8VDH0 Q9CY66 uc008rim.1 uc008rim.2 uc008rim.3 Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable core formed by binding of one or two NOP10- DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate. The complex also interacts with TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs. Specific interactions with snoRNAs or TERC are mediated by GAR1 and NHP2. Associates with NOLC1/NOPP140. H/ACA snoRNPs interact with the SMN complex, consisting of SMN1 or SMN2, GEMIN2/SIP1, DDX20/GEMIN3, and GEMIN4. This is mediated by interaction between GAR1 and SMN1 or SMN2. The SMN complex may be required for correct assembly of the H/ACA snoRNP complex. Component of the telomerase holoenzyme complex composed of one molecule of TERT, one molecule of WRAP53/TCAB1, two molecules of H/ACA ribonucleoprotein complex subunits DKC1, NOP10, NHP2 and GAR1, and a telomerase RNA template component (TERC). The telomerase holoenzyme complex is associated with TEP1, SMG6/EST1A and POT1. Nucleus, nucleolus Nucleus, Cajal body Note=Also localized to Cajal bodies (coiled bodies). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9CY66-1; Sequence=Displayed; Name=2; IsoId=Q9CY66-2; Sequence=VSP_011427; Name=3; IsoId=Q9CY66-3; Sequence=VSP_011426, VSP_011427; Interaction with SMN1 requires at least one of the RGG-box regions. Belongs to the GAR1 family. snoRNA guided rRNA pseudouridine synthesis nuclear chromosome, telomeric region pseudouridine synthesis fibrillar center dense fibrillar component RNA binding protein binding nucleus telomerase holoenzyme complex nucleolus rRNA processing telomere maintenance via telomerase Cajal body snoRNA binding box H/ACA snoRNP complex box H/ACA snoRNA binding ribosome biogenesis telomerase RNA binding box H/ACA telomerase RNP complex uc008rim.1 uc008rim.2 uc008rim.3 
ENSMUST00000029644.16 Ppa2 ENSMUST00000029644.16 pyrophosphatase (inorganic) 2, transcript variant 1 (from RefSeq NM_146141.2) ENSMUST00000029644.1 ENSMUST00000029644.10 ENSMUST00000029644.11 ENSMUST00000029644.12 ENSMUST00000029644.13 ENSMUST00000029644.14 ENSMUST00000029644.15 ENSMUST00000029644.2 ENSMUST00000029644.3 ENSMUST00000029644.4 ENSMUST00000029644.5 ENSMUST00000029644.6 ENSMUST00000029644.7 ENSMUST00000029644.8 ENSMUST00000029644.9 IPYR2_MOUSE NM_146141 Q3UPK3 Q8BTG5 Q91VM9 Q9D1E3 uc008rkm.1 uc008rkm.2 uc008rkm.3 uc008rkm.4 Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function. Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474; EC=3.6.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24577; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Homodimer. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VM9-1; Sequence=Displayed; Name=2; IsoId=Q91VM9-2; Sequence=VSP_011653, VSP_011654; Belongs to the PPase family. magnesium ion binding inorganic diphosphatase activity protein serine/threonine phosphatase activity cytoplasm mitochondrion protein dephosphorylation phosphate-containing compound metabolic process hydrolase activity metal ion binding regulation of mitochondrial membrane potential uc008rkm.1 uc008rkm.2 uc008rkm.3 uc008rkm.4 
ENSMUST00000029645.14 Tdo2 ENSMUST00000029645.14 tryptophan 2,3-dioxygenase (from RefSeq NM_019911.2) ENSMUST00000029645.1 ENSMUST00000029645.10 ENSMUST00000029645.11 ENSMUST00000029645.12 ENSMUST00000029645.13 ENSMUST00000029645.2 ENSMUST00000029645.3 ENSMUST00000029645.4 ENSMUST00000029645.5 ENSMUST00000029645.6 ENSMUST00000029645.7 ENSMUST00000029645.8 ENSMUST00000029645.9 NM_019911 Q8VCW3 Q8VCW3_MOUSE TDO2 Tdo2 tdo variant1 uc008poo.1 uc008poo.2 uc008poo.3 uc008poo.4 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Reaction=L-tryptophan + O2 = N-formyl-L-kynurenine; Xref=Rhea:RHEA:24536, ChEBI:CHEBI:15379, ChEBI:CHEBI:57912, ChEBI:CHEBI:58629; EC=1.13.11.11; Evidence= Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Note=Binds 1 heme group per subunit. ; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. Homotetramer. Dimer of dimers. Belongs to the tryptophan 2,3-dioxygenase family. Lacks conserved residue(s) required for the propagation of feature annotation. tryptophan 2,3-dioxygenase activity tryptophan metabolic process tryptophan catabolic process oxidoreductase activity amino acid binding tryptophan catabolic process to kynurenine tryptophan catabolic process to acetyl-CoA oxygen binding heme binding identical protein binding metal ion binding dioxygenase activity protein homotetramerization oxidation-reduction process response to nitroglycerin uc008poo.1 uc008poo.2 uc008poo.3 uc008poo.4 
ENSMUST00000029649.3 Ctso ENSMUST00000029649.3 cathepsin O (from RefSeq NM_177662.3) CATO_MOUSE ENSMUST00000029649.1 ENSMUST00000029649.2 NM_177662 Q3TM69 Q80V35 Q8BKX0 Q8BM88 uc008pon.1 uc008pon.2 uc008pon.3 This gene encodes a member of the cathepsin family of cysteine proteases that are involved in the degradation of cellular proteins. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme. [provided by RefSeq, Jan 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK034490.1, AK166103.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. Reaction=The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg- NHMec.; EC=3.4.22.42; Lysosome Belongs to the peptidase C1 family. cysteine-type endopeptidase activity extracellular space lysosome proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity proteolysis involved in cellular protein catabolic process uc008pon.1 uc008pon.2 uc008pon.3 
ENSMUST00000029650.9 Ints12 ENSMUST00000029650.9 integrator complex subunit 12 (from RefSeq NM_027927.4) ENSMUST00000029650.1 ENSMUST00000029650.2 ENSMUST00000029650.3 ENSMUST00000029650.4 ENSMUST00000029650.5 ENSMUST00000029650.6 ENSMUST00000029650.7 ENSMUST00000029650.8 INT12_MOUSE NM_027927 Phf22 Q3U2Q5 Q921U2 Q9D168 uc008rkj.1 uc008rkj.2 uc008rkj.3 uc008rkj.4 uc008rkj.5 Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Nucleus Belongs to the Integrator subunit 12 family. molecular_function nucleus snRNA processing integrator complex snRNA 3'-end processing metal ion binding uc008rkj.1 uc008rkj.2 uc008rkj.3 uc008rkj.4 uc008rkj.5 
ENSMUST00000029651.11 Gstcd ENSMUST00000029651.11 glutathione S-transferase, C-terminal domain containing, transcript variant 2 (from RefSeq NM_026231.3) ENSMUST00000029651.1 ENSMUST00000029651.10 ENSMUST00000029651.2 ENSMUST00000029651.3 ENSMUST00000029651.4 ENSMUST00000029651.5 ENSMUST00000029651.6 ENSMUST00000029651.7 ENSMUST00000029651.8 ENSMUST00000029651.9 GSTCD_MOUSE NM_026231 Q5RL51 Q6P8I1 Q8BXR2 Q8BYY6 Q9CTV2 Q9CUA9 Q9CXU7 uc008rkg.1 uc008rkg.2 uc008rkg.3 uc008rkg.4 Cytoplasm Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5RL51-1; Sequence=Displayed; Name=2; IsoId=Q5RL51-2; Sequence=VSP_030826, VSP_030827; Name=3; IsoId=Q5RL51-3; Sequence=VSP_030823; Name=4; IsoId=Q5RL51-4; Sequence=VSP_030824, VSP_030825; Belongs to the GSTCD family. protein binding nucleus nucleoplasm cytoplasm biological_process uc008rkg.1 uc008rkg.2 uc008rkg.3 uc008rkg.4 
ENSMUST00000029652.4 Pdgfc ENSMUST00000029652.4 platelet-derived growth factor, C polypeptide, transcript variant 1 (from RefSeq NM_019971.3) ENSMUST00000029652.1 ENSMUST00000029652.2 ENSMUST00000029652.3 NM_019971 PDGFC_MOUSE Q8CI19 Q99JM4 Q9JHV8 Q9QY71 Scdgf uc008poj.1 uc008poj.2 uc008poj.3 Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts (via CUB domain) with PLAT (via kringle domain) (By similarity). Cytoplasm, cytosol Secreted Nucleus Cytoplasmic granule Cell membrane Note=Sumoylated form is predominant in the nucleus (PubMed:16443219). Stored in alpha granules in platelets (By similarity). Mainly expressed in kidney, testis, liver, heart and brain (at protein level). Highly expressed in airway epithelium, interstitial cells and alveolar macrophages in the lung of mice overexpressing IL13. Expressed in the ovaries. In stage 9.5 dpc-15.5 dpc, widely expressed in the surface ectoderm and later in the germinal layer of the skin, the olfactory and otic placode and their derivatives and the lining of the oral cavity. In stages 14.5 dpc-17.5 expressed in ducts connected to epidermis, and in developing epidermal openings. Highly expressed in the early stages of the developing kidney, in the metanephric mesenchymal aggregates, prefusion skeletal muscle, cardiac myoblasts, and in visceral and vascular smooth muscle. Expression decreased by hypoxia. Up-regulated by EWS-FLI1 transcription factor in tumor-derived cells. Up-regulated by IL13 overexpression in the lung via STAT6 and EGR1. Elevated expression induced by coxsackievirus B3 infection in immunodeficient mice. Overexpressed in the renal fibrosis. Expression in the lung is significantly increased after bleomycin treatment. Down-regulated by retinoic acid and gonadotropin. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG (By similarity). Sumoylated by SUMO1. N-glycosylated. Note=Involved in the development of myocarditis and subsequent fibrosis in the experimental model of coxsackievirus B3-induced chronic myocarditis. Perinatal lethality. Mice have feeding and respiratory difficulties due to a complete cleft of the secondary palate. However, they have reduction of renal fibrogenesis. Mice lacking both PDGFA and PDGFC develop a cleft face, subepidermal blistering, deficiency of renal cortex mesenchyme, spina bifida and skeletal and vascular defects. Belongs to the PDGF/VEGF growth factor family. platelet-derived growth factor receptor binding extracellular region extracellular space nucleus cytoplasm cytosol plasma membrane activation of transmembrane receptor protein tyrosine kinase activity multicellular organism development growth factor activity positive regulation of cell proliferation animal organ morphogenesis cell surface positive regulation of phosphatidylinositol 3-kinase signaling membrane positive regulation of cell migration positive regulation of protein autophosphorylation protein homodimerization activity positive regulation of MAP kinase activity platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation digestive tract development embryonic organ development regulation of peptidyl-tyrosine phosphorylation positive regulation of cell division bone development positive regulation of ERK1 and ERK2 cascade cellular response to amino acid stimulus uc008poj.1 uc008poj.2 uc008poj.3 
ENSMUST00000029653.7 Egf ENSMUST00000029653.7 epidermal growth factor, transcript variant 1 (from RefSeq NM_010113.4) E9QNX6 EGF_MOUSE ENSMUST00000029653.1 ENSMUST00000029653.2 ENSMUST00000029653.3 ENSMUST00000029653.4 ENSMUST00000029653.5 ENSMUST00000029653.6 NM_010113 P01132 Q569W5 Q6P9J2 uc008rih.1 uc008rih.2 uc008rih.3 uc008rih.4 uc008rih.5 This gene encodes epidermal growth factor (EGF), the founding member of the EGF family of growth factors that are implicated in cell proliferation and differentiation. The encoded protein can localize to the membrane and function in juxtacrine signaling or undergo proteolytic processing to generate a soluble form of the hormone. Mice lacking the encoded protein do not exhibit an abnormal phenotype but transgenic mice overexpressing the encoded protein exhibit hypospermatogenesis. [provided by RefSeq, Jul 2016]. EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD). Interacts with RHBDF2. Membrane; Single-pass type I membrane protein. Sequence=CAA24115.1; Type=Frameshift; Evidence=; activation of MAPKK activity activation of MAPK activity angiogenesis positive regulation of receptor internalization Ras guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding calcium ion binding protein binding extracellular region extracellular space plasma membrane epidermal growth factor receptor signaling pathway growth factor activity positive regulation of cell proliferation positive regulation of gene expression positive regulation of peptidyl-threonine phosphorylation membrane integral component of membrane Wnt-protein binding peptidyl-tyrosine phosphorylation positive regulation of cerebellar granule cell precursor proliferation positive regulation of cell migration positive regulation of phosphorylation Wnt-activated receptor activity receptor complex positive regulation of DNA binding positive regulation of MAP kinase activity positive regulation of epidermal growth factor-activated receptor activity positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated regulation of JAK-STAT cascade positive regulation of fibroblast proliferation branching morphogenesis of an epithelial tube regulation of protein secretion regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation negative regulation of secretion regulation of protein transport canonical Wnt signaling pathway mammary gland alveolus development positive regulation of protein tyrosine kinase activity extracellular exosome ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of canonical Wnt signaling pathway regulation of calcium ion import negative regulation of cholesterol efflux positive regulation of hyaluronan biosynthetic process positive regulation of protein localization to early endosome regulation of protein localization to cell surface positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of DNA biosynthetic process uc008rih.1 uc008rih.2 uc008rih.3 uc008rih.4 uc008rih.5 
ENSMUST00000029654.15 Glrb ENSMUST00000029654.15 glycine receptor, beta subunit, transcript variant 4 (from RefSeq NM_010298.7) ENSMUST00000029654.1 ENSMUST00000029654.10 ENSMUST00000029654.11 ENSMUST00000029654.12 ENSMUST00000029654.13 ENSMUST00000029654.14 ENSMUST00000029654.2 ENSMUST00000029654.3 ENSMUST00000029654.4 ENSMUST00000029654.5 ENSMUST00000029654.6 ENSMUST00000029654.7 ENSMUST00000029654.8 ENSMUST00000029654.9 GLRB_MOUSE NM_010298 P48168 Q5U5X3 uc008pog.1 uc008pog.2 uc008pog.3 This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. This gene is transcribed throughout the central nervous system of neonatal and adult mice. In humans, mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:12809985). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down- regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:12809985, PubMed:16672662). Heteropentamer composed of GLRB and GLRA1. Heteropentamer composed of GLRB and GLRA2. Heteropentamer composed of GLRB and GLRA3. Heteropentamer composed of two GLRA1 and three GLRB subunits. Heteropentamer composed of three GLRA1 and two GLRB subunits. Interacts with GLRA1 (By similarity). Interacts with GPHN. P48168; Q8BUV3: Gphn; NbExp=4; IntAct=EBI-7069198, EBI-771218; P48168; Q03555: Gphn; Xeno; NbExp=4; IntAct=EBI-7069198, EBI-349317; Postsynaptic cell membrane ; Multi-pass membrane protein Synapse ll projection, dendrite Cell membrane ; Multi-pass membrane protein Cytoplasm Note=Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane. Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane. Detected in spinal cord, brain and brain stem, especially in the periolivary region, spinal nuclei, trigeminal nucleus, medulla oblongata, pons and midbrain. Detected in the inner plexiform layer of the retina (at protein level) (PubMed:22592841). High levels of expression in cortex, hippocampus, thalamus and cerebellum (PubMed:7920630). Detected in spinal cord (PubMed:7946325). Note=Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability (PubMed:7920630). Neurons from the ventral horn of the spinal cord display reduced inhibitory postsynaptic currents (PubMed:12809985). Likewise, hypoglossal neurons display a dramatic reduction in the frequency and amplitude of postsynaptic inhibitory currents (PubMed:16672662). Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub-subfamily. startle response transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity chloride channel activity protein binding cytoplasm endoplasmic reticulum plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction neuropeptide signaling pathway chemical synaptic transmission acrosome reaction nervous system development visual perception adult walking behavior drug binding external side of plasma membrane membrane integral component of membrane glycine binding extracellular-glycine-gated ion channel activity extracellular-glycine-gated chloride channel activity glycine-gated chloride channel complex cell junction dendrite ion transmembrane transport chloride channel complex regulation of membrane potential cell projection neuron projection response to amino acid synapse postsynaptic membrane neurological system process neuromuscular process protein heterooligomerization synaptic transmission, glycinergic righting reflex regulation of postsynaptic membrane potential excitatory postsynaptic potential gamma-aminobutyric acid receptor clustering GABA-ergic synapse chloride transmembrane transport transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc008pog.1 uc008pog.2 uc008pog.3 
ENSMUST00000029658.14 Enpep ENSMUST00000029658.14 glutamyl aminopeptidase (from RefSeq NM_007934.3) ENSMUST00000029658.1 ENSMUST00000029658.10 ENSMUST00000029658.11 ENSMUST00000029658.12 ENSMUST00000029658.13 ENSMUST00000029658.2 ENSMUST00000029658.3 ENSMUST00000029658.4 ENSMUST00000029658.5 ENSMUST00000029658.6 ENSMUST00000029658.7 ENSMUST00000029658.8 ENSMUST00000029658.9 Enpep NM_007934 Q52JJ6 Q52JJ6_MOUSE uc008rhy.1 uc008rhy.2 uc008rhy.3 Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. Reaction=Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.; EC=3.4.11.7; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Note=Binds 1 zinc ion per subunit. Homodimer; disulfide-linked. Belongs to the peptidase M1 family. regulation of systemic arterial blood pressure by renin-angiotensin aminopeptidase activity plasma membrane proteolysis peptidase activity metallopeptidase activity zinc ion binding cell proliferation membrane integral component of membrane cell migration hydrolase activity metal ion binding metalloaminopeptidase activity uc008rhy.1 uc008rhy.2 uc008rhy.3 
ENSMUST00000029662.12 Alpk1 ENSMUST00000029662.12 alpha-kinase 1 (from RefSeq NM_027808.1) Alpk1 E9QNX4 E9QNX4_MOUSE ENSMUST00000029662.1 ENSMUST00000029662.10 ENSMUST00000029662.11 ENSMUST00000029662.2 ENSMUST00000029662.3 ENSMUST00000029662.4 ENSMUST00000029662.5 ENSMUST00000029662.6 ENSMUST00000029662.7 ENSMUST00000029662.8 ENSMUST00000029662.9 NM_027808 uc012cxm.1 uc012cxm.2 protein serine/threonine kinase activity ATP binding protein phosphorylation uc012cxm.1 uc012cxm.2 
ENSMUST00000029663.11 Aimp1 ENSMUST00000029663.11 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1, transcript variant 1 (from RefSeq NM_007926.2) Aimp1 ENSMUST00000029663.1 ENSMUST00000029663.10 ENSMUST00000029663.2 ENSMUST00000029663.3 ENSMUST00000029663.4 ENSMUST00000029663.5 ENSMUST00000029663.6 ENSMUST00000029663.7 ENSMUST00000029663.8 ENSMUST00000029663.9 NM_007926 Q3UZG4 Q3UZG4_MOUSE Scye1 uc008rjx.1 uc008rjx.2 uc008rjx.3 tRNA binding negative regulation of endothelial cell proliferation RNA binding cytosol cell-cell signaling cell surface aminoacyl-tRNA synthetase multienzyme complex protein homodimerization activity blood vessel morphogenesis leukocyte migration GTPase binding defense response to virus uc008rjx.1 uc008rjx.2 uc008rjx.3 
ENSMUST00000029665.7 Dkk2 ENSMUST00000029665.7 dickkopf WNT signaling pathway inhibitor 2 (from RefSeq NM_020265.4) DKK2_MOUSE Dkk2 ENSMUST00000029665.1 ENSMUST00000029665.2 ENSMUST00000029665.3 ENSMUST00000029665.4 ENSMUST00000029665.5 ENSMUST00000029665.6 NM_020265 Q8BFW0 Q9QYZ8 uc008rjw.1 uc008rjw.2 uc008rjw.3 Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP5 and LRP6. Secreted. Expressed in the oral mesenchyme lingual to the developing mandibular tooth buds at 13.5 dpc (PubMed:27713059). Expressed in the developing cochlea at 12.5 and 15.5 dpc (PubMed:27550540). Expressed in the forelimb at 13.5 dpc (PubMed:27550540). The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6. May be proteolytically processed by a furin-like protease. Belongs to the dickkopf family. extracellular region extracellular space multicellular organism development Wnt signaling pathway negative regulation of Wnt signaling pathway co-receptor binding receptor antagonist activity negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway negative regulation of receptor activity uc008rjw.1 uc008rjw.2 uc008rjw.3 
ENSMUST00000029666.14 Papss1 ENSMUST00000029666.14 3'-phosphoadenosine 5'-phosphosulfate synthase 1, transcript variant 1 (from RefSeq NM_011863.3) Asapk Atpsk1 ENSMUST00000029666.1 ENSMUST00000029666.10 ENSMUST00000029666.11 ENSMUST00000029666.12 ENSMUST00000029666.13 ENSMUST00000029666.2 ENSMUST00000029666.3 ENSMUST00000029666.4 ENSMUST00000029666.5 ENSMUST00000029666.6 ENSMUST00000029666.7 ENSMUST00000029666.8 ENSMUST00000029666.9 NM_011863 PAPS1_MOUSE Papss Q3U647 Q60967 uc008rjr.1 uc008rjr.2 uc008rjr.3 Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:7493984). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (By similarity). Reaction=ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate; Xref=Rhea:RHEA:18133, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58243; EC=2.7.7.4; Evidence=; Reaction=adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+); Xref=Rhea:RHEA:24152, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58243, ChEBI:CHEBI:58339, ChEBI:CHEBI:456216; EC=2.7.1.25; Evidence=; Sulfur metabolism; sulfate assimilation. Homodimer. Expressed in the neonatal brain and in cartilage. In the N-terminal section; belongs to the APS kinase family. In the C-terminal section; belongs to the sulfate adenylyltransferase family. sulfate assimilation nucleotide binding catalytic activity adenylylsulfate kinase activity sulfate adenylyltransferase (ATP) activity ATP binding metabolic process sulfate adenylyltransferase complex (ATP) kinase activity phosphorylation transferase activity nucleotidyltransferase activity protein homodimerization activity 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process uc008rjr.1 uc008rjr.2 uc008rjr.3 
ENSMUST00000029667.13 Kcnq5 ENSMUST00000029667.13 potassium voltage-gated channel, subfamily Q, member 5, transcript variant 2 (from RefSeq NM_023872.3) ENSMUST00000029667.1 ENSMUST00000029667.10 ENSMUST00000029667.11 ENSMUST00000029667.12 ENSMUST00000029667.2 ENSMUST00000029667.3 ENSMUST00000029667.4 ENSMUST00000029667.5 ENSMUST00000029667.6 ENSMUST00000029667.7 ENSMUST00000029667.8 ENSMUST00000029667.9 KCNQ5_MOUSE NM_023872 Q4QXS5 Q8BSF6 Q9JK45 uc007alq.1 uc007alq.2 uc007alq.3 uc007alq.4 uc007alq.5 Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Heteromultimer with KCNQ3. Heterotetramer with KCNQ1; has a voltage-gated potassium channel activity. Cell membrane ; Multi-pass membrane protein The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The activity of this channel is modulated by zinc, pH and volume changes. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity calmodulin binding plasma membrane integral component of plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane clathrin coat regulation of ion transmembrane transport transmembrane transport potassium ion transmembrane transport uc007alq.1 uc007alq.2 uc007alq.3 uc007alq.4 uc007alq.5 
ENSMUST00000029670.7 Ptgfr ENSMUST00000029670.7 prostaglandin F receptor (from RefSeq NM_008966.3) ENSMUST00000029670.1 ENSMUST00000029670.2 ENSMUST00000029670.3 ENSMUST00000029670.4 ENSMUST00000029670.5 ENSMUST00000029670.6 NM_008966 Ptgfr Q60I90 Q60I90_MOUSE fp uc008rsn.1 uc008rsn.2 uc008rsn.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity prostaglandin receptor activity prostaglandin F receptor activity extracellular region cytoplasm plasma membrane signal transduction G-protein coupled receptor signaling pathway positive regulation of cell proliferation membrane integral component of membrane calcium-mediated signaling using intracellular calcium source cellular response to prostaglandin D stimulus uc008rsn.1 uc008rsn.2 uc008rsn.3 
ENSMUST00000029671.9 Ifi44 ENSMUST00000029671.9 interferon-induced protein 44, transcript variant 1 (from RefSeq NM_133871.3) ENSMUST00000029671.1 ENSMUST00000029671.2 ENSMUST00000029671.3 ENSMUST00000029671.4 ENSMUST00000029671.5 ENSMUST00000029671.6 ENSMUST00000029671.7 ENSMUST00000029671.8 IFI44_MOUSE Mtap44 NM_133871 Q8BV66 Q9ER37 uc008rsk.1 uc008rsk.2 uc008rsk.3 uc008rsk.4 uc008rsk.5 This protein aggregates to form microtubular structures. Cytoplasm Belongs to the IFI44 family. molecular_function cytoplasm immune response response to bacterium uc008rsk.1 uc008rsk.2 uc008rsk.3 uc008rsk.4 uc008rsk.5 
ENSMUST00000029673.10 Efna3 ENSMUST00000029673.10 ephrin A3, transcript variant 1 (from RefSeq NM_010108.2) EFNA3_MOUSE ENSMUST00000029673.1 ENSMUST00000029673.2 ENSMUST00000029673.3 ENSMUST00000029673.4 ENSMUST00000029673.5 ENSMUST00000029673.6 ENSMUST00000029673.7 ENSMUST00000029673.8 ENSMUST00000029673.9 Epl3 Eplg3 Lerk3 NM_010108 O08545 O55217 Q08AV0 uc008pyq.1 uc008pyq.2 uc008pyq.3 Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Interacts with EPHA8; activates EPHA8. Cell membrane; Lipid-anchor, GPI-anchor. Expressed in myogenic progenitor cells. In myogenic progenitor cells, highly expressed at 11.5 dpc and ceases its expression at the late fetal stage (17.5 dpc). Belongs to the ephrin family. plasma membrane axon guidance membrane negative regulation of angiogenesis anchored component of membrane regulation of neuron differentiation ephrin receptor binding ephrin receptor signaling pathway positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process uc008pyq.1 uc008pyq.2 uc008pyq.3 
ENSMUST00000029674.8 Efna4 ENSMUST00000029674.8 ephrin A4 (from RefSeq NM_007910.2) ENSMUST00000029674.1 ENSMUST00000029674.2 ENSMUST00000029674.3 ENSMUST00000029674.4 ENSMUST00000029674.5 ENSMUST00000029674.6 ENSMUST00000029674.7 Efna4 NM_007910 Q3UQB5 Q3UQB5_MOUSE uc008pys.1 uc008pys.2 uc008pys.3 Cell membrane ; Lipid-anchor, GPI-anchor Membrane ; Lipid-anchor, GPI-anchor Belongs to the ephrin family. Lacks conserved residue(s) required for the propagation of feature annotation. membrane ephrin receptor binding ephrin receptor signaling pathway uc008pys.1 uc008pys.2 uc008pys.3 
ENSMUST00000029676.12 Adam15 ENSMUST00000029676.12 ADAM metallopeptidase domain 15, transcript variant 14 (from RefSeq NR_176854.1) A4ZYV2 ADA15_MOUSE ENSMUST00000029676.1 ENSMUST00000029676.10 ENSMUST00000029676.11 ENSMUST00000029676.2 ENSMUST00000029676.3 ENSMUST00000029676.4 ENSMUST00000029676.5 ENSMUST00000029676.6 ENSMUST00000029676.7 ENSMUST00000029676.8 ENSMUST00000029676.9 Mdc15 NR_176854 O88839 Q3TDN7 Q3U7C2 Q3UE21 Q8C7Z0 Q91VS9 Q9QYL2 uc008pyv.1 uc008pyv.2 uc008pyv.3 uc008pyv.4 Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration (By similarity). Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. Interactions with egg membrane could be mediated via binding between the disintegrin-like domain to one or more integrin receptors on the egg. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Interacts specifically with Src family protein-tyrosine kinases (PTKs) (By similarity). Interacts with ITAGV-ITGB3 (vitronectin receptor). Interacts with SH3GL2 and SNX9; this interaction occurs preferentially with ADAM15 precursor, rather than the processed form, suggesting it occurs in a secretory pathway compartment prior to the medial Golgi. Interacts with ITAG9-ITGB1. Interacts with SH3PXD2A (By similarity). Interacts with ITAGV-ITGB1. Interacts with GRB2, HCK, ITSN1, ITSN2, LYN, MAPK1, MAPK3, NCF1, NCK1, nephrocystin, PTK6, SNX33, LCK and SRC (By similarity). Endomembrane system ; Single-pass type I membrane protein Cell junction, adherens junction Cell projection, cilium, flagellum Cytoplasmic vesicle, secretory vesicle, acrosome Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=ADAM15v2; IsoId=O88839-1; Sequence=Displayed; Name=2; Synonyms=ADAM15v1; IsoId=O88839-2; Sequence=VSP_008880; Name=3; Synonyms=ADAM15; IsoId=O88839-3; Sequence=VSP_008881; Name=4; IsoId=O88839-4; Sequence=VSP_008879; Expressed moderately in pericytes of retina. Expressed in testis and in spermatozoa from the caput, corpus, and cauda epididymis, as well as in non-capacitated and acrosome-reacted sperm (at protein level). Highly expressed in heart, brain, lung, and kidney. Expressed at lower levels in spleen, liver, testis and muscle. At 13.5 dpc, strongly expressed in the developing vasculature of the endocardium. At P17, expressed throughout the retina (at protein level). At 9.5 dpc and thereafter, prominently expressed in the vasculature, including in ventral and dorsal aorta and the caudal artery. In developing heart, detected in endocardium and blood vessels of the ventricle, bulbus arteriosus, and atrium. Also highly expressed in hypertrophic cells of the developing bone. In adult, expressed prominently in brain, including in hippocampus, cerebellum, pons, thalamus, cortex, and olfactory bulb. By hypoxic stimulus in retina (at protein level). Up- regulated by VEGF in retina. The cytoplasmic domain is required for SH3GL2- and SNX9- binding. Disintegrin domain binds to integrin alphaV-beta3. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. An additional membrane proximal site of cleavage affects a small percentage of the proteins and results in disulfide-linked fragments. The prodomain is apparently cleaved in several positions that are N-terminal of the furin cleavage site. May be partially sialylated. Phosphorylation increases association with PTKs. Mice targeted for deletion of the first 27 amino acids of the ADAM15 N-terminal sequence are viable and fertile, showing no major developmental defects and displaying normal mortality or morbidity. These mutant mice, however, exhibit significantly reduced ischemia-induced retinal neovascularization, choroidal neovascularization at rupture sites in Bruch's membrane, and VEGF- induced subretinal neovascularization, and develop significantly smaller tumors following implantation of B16F0 melanoma cells. Aging mutant mice exhibit accelerated development of osteoarthritic lesions in knee joints. angiogenesis acrosomal vesicle negative regulation of cell-matrix adhesion immune response to tumor cell metalloendopeptidase activity integrin binding protein binding extracellular space adherens junction cilium proteolysis cell adhesion integrin-mediated signaling pathway peptidase activity metallopeptidase activity male gonad development cell surface endomembrane system membrane integral component of membrane hydrolase activity SH3 domain binding cell junction negative regulation of cell growth negative regulation of cell migration collagen catabolic process cytoplasmic vesicle motile cilium tissue regeneration cell projection innate immune response metal ion binding cardiac epithelial to mesenchymal transition extracellular exosome negative regulation of receptor binding cellular response to phorbol 13-acetate 12-myristate response to hypobaric hypoxia uc008pyv.1 uc008pyv.2 uc008pyv.3 uc008pyv.4 
ENSMUST00000029677.9 Zbtb7b ENSMUST00000029677.9 zinc finger and BTB domain containing 7B, transcript variant 2 (from RefSeq NM_009565.6) ENSMUST00000029677.1 ENSMUST00000029677.2 ENSMUST00000029677.3 ENSMUST00000029677.4 ENSMUST00000029677.5 ENSMUST00000029677.6 ENSMUST00000029677.7 ENSMUST00000029677.8 NM_009565 Q64321 Q80VV5 Thpok ZBT7B_MOUSE Zbtb7b Zfp67 uc008pzd.1 uc008pzd.2 uc008pzd.3 Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner (PubMed:15729333, PubMed:29420538). Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision (PubMed:15729333, PubMed:24880459, PubMed:18258917, PubMed:23481257). Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate (PubMed:24880459). During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci (PubMed:22730529). Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells (PubMed:23105140). Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (PubMed:29420538). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:7937772). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation (PubMed:28784777). Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (PubMed:28784777). Homodimerizes (PubMed:22730529). Interacts with NCL, NEDD4 and YBX1 (PubMed:28784777). Interacts with HNRNPU (via RNA-binding RGG-box region); the interaction facilitates the recruitment of long non-coding RNA Blnc1 by ZBTB7B (PubMed:28784777). Interacts with HDAC4 and HDAC5; the interaction allows the recruitment of HDAC4 and HDAC5 on CD8 loci for deacetylation and possible inhibition of CD8 genes expression (PubMed:22730529). Q64321; Q8CIH5: Plcg2; NbExp=3; IntAct=EBI-642868, EBI-617954; Q64321; Q61029: Tmpo; NbExp=2; IntAct=EBI-642868, EBI-6172136; Nucleus Widely expressed, with a higher level in skin. Expressed in thymus. Restricted to CD4 cells (mature single positive CD4(+) and intermediate CD4(+)CD8(+) cells). Expressed in the luminal epithelial cells in the mammary glands where is up-regulated at late pregnancy and lactation (PubMed:29420538). Expression is enriched in brown fat (PubMed:28784777). Expressed, beginning at 9.5 days of gestation and at 10.5 days in regions destined to become skin. In adult animals, expression is predominantly in skin (PubMed:7937772). Expression is significantly increased during brown adipocyte differentiation (PubMed:28784777). Expression in mammary glands is induced by insulin. Acetylated directly and specifically by EP300. EP300-mediated acetylation of Lys-210, Lys-216 and Lys-339 stabilizes the protein by antagonizing ubiquitin conjugation. Ubiquitinated, leading to proteasomal degradation. Competes with acetylation on Lys-210, Lys-216 and Lys-339. Note=Defects in Zbtb7b are the cause of helper deficient disease (HD) or helpless disease. HD and helpless mice are distinguished by the virtual absence of peripheral T-cells of the CD4(+)CD8(-) major histocompatibility complex (MHC) class II-restricted T-helper subset due to a specific block in thymic development. The developmental defect is selective for CD4(+)CD8(-) cells; the maturation of CD4(-)CD8(+) and gamma delta T-cells is normal indicating that lineage commitment is specifically perturbed without affecting positive selection. In helpless disease, NKT cells are hyperproliferative, most lack CD4 and instead express CD8. The majority of NKT cells in the thymus produce IL17 with high frequency while very few produce IFNG or other cytokines (PubMed:23105140). Mutant females are unable to efficiently secrete milk lipid and to nurse the offspring. They show normal mammary gland morphogenesis in puberty and alveologenesis in pregnancy, but are defective in triggering the onset of lactation upon parturition with large cellular lipid droplets retained within alveolar epithelial cells (PubMed:29420538). Mice are more sensitive to cold temperature, with impaired cold-induced transcriptional remodeling in brown fat and diminished browning of inguinal white fat (PubMed:28784777). Sequence=AAA61956.1; Type=Frameshift; Evidence=; Sequence=AAA61956.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence=; Sequence=CAA85307.1; Type=Frameshift; Evidence=; Sequence=CAA85307.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding NK T cell differentiation nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm multicellular organism development lactation regulation of gene expression positive regulation of gene expression negative regulation of gene expression cell differentiation positive regulation of histone deacetylation response to insulin protein homodimerization activity histone deacetylase binding regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of CD4-positive, alpha-beta T cell differentiation regulation of CD8-positive, alpha-beta T cell differentiation negative regulation of CD8-positive, alpha-beta T cell differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of insulin receptor signaling pathway metal ion binding negative regulation of NK T cell proliferation regulation of transcription involved in cell fate commitment interleukin-17 secretion positive regulation of brown fat cell differentiation adaptive thermogenesis negative regulation of T-helper 17 cell differentiation positive regulation of SREBP signaling pathway uc008pzd.1 uc008pzd.2 uc008pzd.3 
ENSMUST00000029679.4 Cks1b ENSMUST00000029679.4 CDC28 protein kinase 1b (from RefSeq NM_016904.1) CKS1_MOUSE Cks1 ENSMUST00000029679.1 ENSMUST00000029679.2 ENSMUST00000029679.3 NM_016904 P33551 P61025 Q6ZWX7 Sid1334 uc008pzl.1 uc008pzl.2 uc008pzl.3 Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. Forms a homohexamer that can probably bind six kinase subunits. Belongs to the CKS family. regulation of cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein kinase holoenzyme complex regulation of transcription, DNA-templated cell cycle regulation of mitotic cell cycle cell proliferation cyclin-dependent protein serine/threonine kinase regulator activity SCF ubiquitin ligase complex protein kinase binding histone binding ubiquitin binding mitotic cell cycle phase transition positive regulation of cyclin-dependent protein serine/threonine kinase activity cell division cyclin-dependent protein serine/threonine kinase activator activity uc008pzl.1 uc008pzl.2 uc008pzl.3 
ENSMUST00000029682.11 Thbs3 ENSMUST00000029682.11 thrombospondin 3, transcript variant 1 (from RefSeq NM_013691.3) ENSMUST00000029682.1 ENSMUST00000029682.10 ENSMUST00000029682.2 ENSMUST00000029682.3 ENSMUST00000029682.4 ENSMUST00000029682.5 ENSMUST00000029682.6 ENSMUST00000029682.7 ENSMUST00000029682.8 ENSMUST00000029682.9 NM_013691 Q05895 Q6LCE0 Q7TN15 TSP3_MOUSE Tsp3 uc008pyg.1 uc008pyg.2 uc008pyg.3 uc008pyg.4 Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. Oligomer; disulfide-linked. Brain, lung and cartilage. Belongs to the thrombospondin family. growth plate cartilage development calcium ion binding extracellular region cell adhesion heparin binding ossification involved in bone maturation perinuclear region of cytoplasm bone trabecula formation uc008pyg.1 uc008pyg.2 uc008pyg.3 uc008pyg.4 
ENSMUST00000029686.4 Hcn3 ENSMUST00000029686.4 hyperpolarization-activated, cyclic nucleotide-gated K+ 3, transcript variant 5 (from RefSeq NR_176935.1) ENSMUST00000029686.1 ENSMUST00000029686.2 ENSMUST00000029686.3 HCN3_MOUSE Hac3 NR_176935 O88705 uc008pxr.1 uc008pxr.2 uc008pxr.3 Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions. Inhibited by Cs(1+) and ivabradine. Is apparently not activated by cAMP or cGMP. Homotetramer. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits (By similarity). Interacts with KCTD3 and PEX5L (PubMed:23382386). Cell membrane ulti-pass membrane protein Detected in hypothalamus, amygdala, olfactory bulb, hippocampus and retina (at protein level). Highly expressed in brain and heart, in particular in ventricle, atrium and in sinoatrial node (SAN). Detected at low levels in skeletal muscle and lung. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Belongs to the potassium channel HCN family. nucleotide binding ion channel activity voltage-gated ion channel activity voltage-gated sodium channel activity voltage-gated potassium channel activity potassium channel activity sodium channel activity protein binding plasma membrane integral component of plasma membrane ion transport potassium ion transport sodium ion transport membrane integral component of membrane axon dendrite cAMP binding regulation of ion transmembrane transport sodium ion transmembrane transport regulation of membrane potential neuronal cell body cone cell pedicle synapse transmembrane transport potassium ion transmembrane transport response to cisplatin cellular response to dopamine intracellular cAMP activated cation channel activity uc008pxr.1 uc008pxr.2 uc008pxr.3 
ENSMUST00000029692.15 Rit1 ENSMUST00000029692.15 Ras-like without CAAX 1, transcript variant 1 (from RefSeq NM_009069.5) ENSMUST00000029692.1 ENSMUST00000029692.10 ENSMUST00000029692.11 ENSMUST00000029692.12 ENSMUST00000029692.13 ENSMUST00000029692.14 ENSMUST00000029692.2 ENSMUST00000029692.3 ENSMUST00000029692.4 ENSMUST00000029692.5 ENSMUST00000029692.6 ENSMUST00000029692.7 ENSMUST00000029692.8 ENSMUST00000029692.9 NM_009069 P70426 RIT1_MOUSE Rit uc008pwh.1 uc008pwh.2 uc008pwh.3 uc008pwh.4 Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Alternates between an inactive form bound to GDP and an active form bound to GTP. Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP- bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1 association is dependent upon the GTP-bound state (By similarity). Interacts with RGL3. Cell membrane. Expressed in many tissues. Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation. Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are very much 10-fold faster than those of most Ras subfamily members. Belongs to the small GTPase superfamily. Ras family. nucleotide binding GTPase activity calmodulin binding GTP binding plasma membrane signal transduction Ras protein signal transduction membrane GDP binding uc008pwh.1 uc008pwh.2 uc008pwh.3 uc008pwh.4 
ENSMUST00000029696.11 Khdc4 ENSMUST00000029696.11 KH domain containing 4, pre-mRNA splicing factor, transcript variant 4 (from RefSeq NR_151827.2) Blom7 ENSMUST00000029696.1 ENSMUST00000029696.10 ENSMUST00000029696.2 ENSMUST00000029696.3 ENSMUST00000029696.4 ENSMUST00000029696.5 ENSMUST00000029696.6 ENSMUST00000029696.7 ENSMUST00000029696.8 ENSMUST00000029696.9 KHDC4_MOUSE Kiaa0907 NR_151827 Q3TCX3 Q69ZW1 Q8BUQ0 Q923C9 Q9CZ63 Q9D207 uc008pwg.1 uc008pwg.2 uc008pwg.3 uc008pwg.4 RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches. Interacts with PRPF19. Isoform 2: Interacts with U2AF65. Q3TCX3; Q15637: SF1; Xeno; NbExp=3; IntAct=EBI-11298408, EBI-744603; Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3TCX3-1; Sequence=Displayed; Name=2; IsoId=Q3TCX3-2; Sequence=VSP_027248, VSP_027249; Name=3; IsoId=Q3TCX3-3; Sequence=VSP_027246, VSP_027247; Name=4; IsoId=Q3TCX3-4; Sequence=VSP_027244, VSP_027245; The C-terminal part is necessary for the interaction with the PRP19C/Prp19 complex/NTC/Nineteen complex. The KH domains mediate RNA-binding. Belongs to the KHDC4 family. Sequence=BAD32335.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA binding protein binding nucleus spliceosomal complex cytoplasm mRNA splice site selection mRNA processing RNA splicing uc008pwg.1 uc008pwg.2 uc008pwg.3 uc008pwg.4 
ENSMUST00000029698.15 Lamtor2 ENSMUST00000029698.15 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2, transcript variant 1 (from RefSeq NM_031248.4) ENSMUST00000029698.1 ENSMUST00000029698.10 ENSMUST00000029698.11 ENSMUST00000029698.12 ENSMUST00000029698.13 ENSMUST00000029698.14 ENSMUST00000029698.2 ENSMUST00000029698.3 ENSMUST00000029698.4 ENSMUST00000029698.5 ENSMUST00000029698.6 ENSMUST00000029698.7 ENSMUST00000029698.8 ENSMUST00000029698.9 LTOR2_MOUSE Mapbpip NM_031248 Q9JHS3 Robld3 uc008pvo.1 uc008pvo.2 uc008pvo.3 As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (By similarity). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (By similarity). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (PubMed:15263099). Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5 (PubMed:15016825, PubMed:15263099, PubMed:15740743, PubMed:19177150). LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer (PubMed:15016825, PubMed:15263099, PubMed:15740743, PubMed:19177150). The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and RagD/RRAGD; regulated by amino acid availability (PubMed:15016825, PubMed:15263099, PubMed:15740743, PubMed:19177150). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (By similarity). Interacts with LAMTOR1 and LAMTOR3; the interaction is direct. Interacts with MAPK1 and MAP2K1 (PubMed:11266467). Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator (By similarity). Q9JHS3; O88653: Lamtor3; NbExp=2; IntAct=EBI-1038198, EBI-1039530; Q9JHS3; Q6P791: Lamtor1; Xeno; NbExp=4; IntAct=EBI-1038198, EBI-919067; Late endosome membrane eripheral membrane protein ; Cytoplasmic side Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Recruited to lysosome and endosome membranes by LAMTOR1. Ubiquitous. Belongs to the GAMAD family. activation of MAPKK activity regulation of cell growth guanyl-nucleotide exchange factor activity protein binding lysosome lysosomal membrane endosome late endosome membrane late endosome membrane positive regulation of TOR signaling cellular protein localization binding, bridging cellular response to amino acid stimulus Ragulator complex uc008pvo.1 uc008pvo.2 uc008pvo.3 
ENSMUST00000029699.13 Lmna ENSMUST00000029699.13 lamin A, transcript variant 1 (from RefSeq NM_001002011.3) B3RH23 B3RH24 ENSMUST00000029699.1 ENSMUST00000029699.10 ENSMUST00000029699.11 ENSMUST00000029699.12 ENSMUST00000029699.2 ENSMUST00000029699.3 ENSMUST00000029699.4 ENSMUST00000029699.5 ENSMUST00000029699.6 ENSMUST00000029699.7 ENSMUST00000029699.8 ENSMUST00000029699.9 LMNA_MOUSE Lmn1 NM_001002011 P11516 P48678 P97859 Q3TIH0 Q3TTS8 Q3U733 Q3U7I5 Q3UCA0 Q3UCJ8 Q3UCU3 Q91WF2 Q9DC21 uc008pvj.1 uc008pvj.2 uc008pvj.3 uc008pvj.4 uc008pvj.5 This gene encodes a protein that is a member of the lamin family. Nuclear lamins, intermediate filament-like proteins, are the major components of the nuclear lamina, a protein meshwork associated with the inner nuclear membrane. This meshwork is thought to maintain the integrity of the nuclear envelope, participate in chromatin organization, and regulate gene transcription. Vertebrate lamins consist of two types, A and B. This protein is an A-type and is proposed to be developmentally regulated. In mouse deficiency of this gene is associated with muscular dystrophy. Mouse lines with different mutations in this gene serve as pathophysiological models for several human laminopathies. In humans, mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]. Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (PubMed:10579712). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10579712). Recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (By similarity). Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10579712). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:11799477, PubMed:19124654, PubMed:21547077, PubMed:23535822). Required for osteoblastogenesis and bone formation (By similarity). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone. Required for cardiac homeostasis (PubMed:21982926, PubMed:26436652). Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence. [Isoform C2]: Isoform C2 may have a role in determining the organization of nuclear and chromosomal structures during spermatogenesis. Homodimer of lamin A and lamin C (By similarity). Interacts with lamin-associated polypeptides IA, IB and TMPO-alpha, RB1 and with emerin (By similarity). Proteolytically processed isoform A interacts with NARF (By similarity). Interacts with SREBF1, SREBF2, SUN1, SUN2 and TMEM43 (PubMed:11929849, PubMed:16380439, PubMed:16648470, PubMed:18230648, PubMed:19843581, PubMed:19933576). Interacts with TMEM201 (PubMed:22349700). Prelamin-A/C interacts with EMD. Interacts with DMPK; may regulate nuclear envelope stability (By similarity). Interacts with MLIP (PubMed:26436652, PubMed:21498514). Interacts with SUV39H1; the interaction increases stability of SUV39H1 (PubMed:23695662). Interacts with ITSN1 isoform 2 (By similarity). Interacts with IFFO1; the interaction forms an interior nucleoskeleton and the recruitment to DNA double-strand breaks (By similarity). [Isoform C]: Interacts (via C-terminus) with LEMD2 (via N- terminus) (in vitro). Nucleus Nucleus envelope Nucleus lamina Nucleus, nucleoplasm Nucleus matrix Note=Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleavage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C. Event=Alternative splicing; Named isoforms=3; Comment=Isoform A and isoform C are present in equal amounts in the lamina of mammals.; Name=A; IsoId=P48678-1; Sequence=Displayed; Name=C; IsoId=P48678-2, P11516-1; Sequence=VSP_017064, VSP_017065; Name=C2; IsoId=P48678-3, P11516-2; Sequence=VSP_002471, VSP_002472, VSP_017064, VSP_017065; Expressed in liver and in bone marrow (at protein level) (PubMed:10579712, PubMed:21547077). Expressed in cardiomyocytes (PubMed:26436652). [Isoform C2]: Specifically expressed in germ cells. Proteolytic cleavage of the C-terminal of 18 residues of prelamin- A/C results in the production of lamin-A/C (PubMed:17652517). The prelamin-A/C maturation pathway includes farnesylation of CAAX motif by protein farnesyltransferase (FNTA and FNTB), removal of the last three amino acids (-AAX) by RCE1/FACE2 and/or ZMPSTE24, methylation of the C- terminal cysteine by ICMT and endoproteolytic removal of the last 15 C- terminal amino acids by ZMPSTE24 (PubMed:17652517). Proteolytic cleavage requires prior farnesylation and methylation, and absence of these blocks cleavage (PubMed:17652517). Farnesylation of prelamin-A/C facilitates nuclear envelope targeting. Sumoylation is necessary for the localization to the nuclear envelope. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Phosphorylation status of S-22 determines its localization between double-strand break (DSB) sites and the nuclear matrix (By similarity). [Isoform C]: Isoform C is phosphorylated on Ser-392, Ser-407 and Ser-409 at interphase. The N-terminus is blocked. Mutant mice survive postnatally for 6-8 weeks and show skeletal and cardiac myopathy, sarcopenia, osteopenia, decreased bone formation, neuropathy, abnormal neuromuscular junctions, decreased skeletal muscle growth and decreased muscle satellite cell proliferation. They develop ventricular dilation and cardiac dysfunction. Within 2-3 weeks they show a reduction in their growth rate and by week 4 their growth ceases with their mean body weight being half of that of the wild-type or the heterozygous littermates. Simultaneous knockout of LMNA and LAP2 results in partial rescue of the phenotype, with a 30% increase in survival rate and a 25-50% increase in body weight. Double knockouts for MLIP and LMNA die sooner than single LMNA knockout. They develop much more severe ventricular dilation and cardiac dysfunction (PubMed:26436652). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. Belongs to the intermediate filament family. Sequence=BAE31539.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding nucleus nuclear envelope lamin filament nuclear lamina nucleoplasm intermediate filament protein import into nucleus nucleus organization nuclear envelope organization muscle organ development protein phosphatase 1 binding negative regulation of cell proliferation positive regulation of gene expression nuclear matrix establishment of cell polarity regulation of cell migration establishment or maintenance of microtubule cytoskeleton polarity regulation of protein stability nuclear membrane regulation of telomere maintenance protein localization to nucleus cellular protein localization identical protein binding positive regulation of osteoblast differentiation perinuclear region of cytoplasm ventricular cardiac muscle cell development cellular response to hypoxia negative regulation of mesenchymal cell proliferation negative regulation of release of cytochrome c from mitochondria positive regulation of cell aging positive regulation of histone H3-K9 trimethylation regulation of protein localization to nucleus negative regulation of cardiac muscle hypertrophy in response to stress negative regulation of adipose tissue development negative regulation of extrinsic apoptotic signaling pathway uc008pvj.1 uc008pvj.2 uc008pvj.3 uc008pvj.4 uc008pvj.5 
ENSMUST00000029708.8 Naxe ENSMUST00000029708.8 NAD(P)HX epimerase, transcript variant 2 (from RefSeq NM_144897.4) Aibp Apoa1bp ENSMUST00000029708.1 ENSMUST00000029708.2 ENSMUST00000029708.3 ENSMUST00000029708.4 ENSMUST00000029708.5 ENSMUST00000029708.6 ENSMUST00000029708.7 NM_144897 NNRE_MOUSE Naxe Q8K4Z3 uc008ptu.1 uc008ptu.2 uc008ptu.3 Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) (PubMed:21994945). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity). Reaction=(6R)-NADHX = (6S)-NADHX; Xref=Rhea:RHEA:32215, ChEBI:CHEBI:64074, ChEBI:CHEBI:64075; EC=5.1.99.6; Evidence=; Reaction=(6R)-NADPHX = (6S)-NADPHX; Xref=Rhea:RHEA:32227, ChEBI:CHEBI:64076, ChEBI:CHEBI:64077; EC=5.1.99.6; Evidence=; Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence=; Note=Binds 1 potassium ion per subunit. Kinetic parameters: KM=1.6 uM for (R)-NADHX ; KM=0.33 uM for (R)-NADPHX ; Vmax=0.26 umol/min/mg enzyme toward (R)-NADHX ; Vmax=1.2 umol/min/mg enzyme toward (R)-NADPHX ; Homodimer (PubMed:18202122). Interacts with APOA1 and APOA2 (By similarity). Mitochondrion Secreted te=In sperm, secretion gradually increases during capacitation. Detected in testis and sperm (at protein level). Expressed at high levels in heart, liver, kidney, and testis. Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation. Belongs to the NnrE/AIBP family. nucleotide binding extracellular region extracellular space nucleoplasm mitochondrion cytosol cilium isomerase activity identical protein binding intracellular membrane-bounded organelle cell body nicotinamide nucleotide metabolic process metal ion binding NADHX epimerase activity NADPHX epimerase activity uc008ptu.1 uc008ptu.2 uc008ptu.3 
ENSMUST00000029709.7 Sh2d2a ENSMUST00000029709.7 SH2 domain containing 2A, transcript variant 3 (from RefSeq NM_001411077.1) ENSMUST00000029709.1 ENSMUST00000029709.2 ENSMUST00000029709.3 ENSMUST00000029709.4 ENSMUST00000029709.5 ENSMUST00000029709.6 Lad NM_001411077 Q9JHP6 Q9QXK9 Ribp SH22A_MOUSE uc008psz.1 uc008psz.2 uc008psz.3 Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in p56-LCK-mediated T- cell signaling. Could be involved in the regulation of responses to T- cell activation stimuli, specifically proliferation and lymphokine production. Interactions with ITK and TXK may provide important biochemical links of these two important kinases with other components in the T-cell activation machinery. Interacts with KDR (By similarity). Interacts with p56-LCK, TXK and ITK. Q9QXK9; P06240: Lck; NbExp=3; IntAct=EBI-1644, EBI-1401; Cytoplasm. Cell membrane. Note=Redistributed from cytoplasm to the plasma membrane in a T-cell activation-dependent manner. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QXK9-1; Sequence=Displayed; Name=2; IsoId=Q9QXK9-2; Sequence=VSP_003967; Expression limited to tissues of the immune system and, in particular, activated T-cells and natural killer cells. Expressed in the thymus, lymph node, and to a lesser extent, in the spleen and bone marrow. According to PubMed:10553045, also expressed in the lung. Up-regulated substantially after T-cell activation. Phosphorylated on tyrosine residues upon TCR-stimulation. Proliferation of SH2D2A-deficient T-cells in response to T-cell receptor (TCR)-mediated activation is significantly impaired. These activated T-cells are defective in the production of interleukin (IL)-2 and interferon gamma, but not IL-4. SH3/SH2 adaptor activity protein binding cytoplasm plasma membrane cell proliferation positive regulation of signal transduction membrane SH3 domain binding uc008psz.1 uc008psz.2 uc008psz.3 
ENSMUST00000029711.9 Insrr ENSMUST00000029711.9 insulin receptor-related receptor (from RefSeq NM_011832.2) B2RQC5 ENSMUST00000029711.1 ENSMUST00000029711.2 ENSMUST00000029711.3 ENSMUST00000029711.4 ENSMUST00000029711.5 ENSMUST00000029711.6 ENSMUST00000029711.7 ENSMUST00000029711.8 INSRR_MOUSE Irr NM_011832 Q9WTL4 uc008psy.1 uc008psy.2 uc008psy.3 Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain (By similarity). Membrane ; Single-pass type I membrane protein Highly expressed in the islets as well as in pancreatic beta-cells. The extracellular domain is required for sensing alterations in external pH. Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5. Renal function is impaired, with reduced ability of the collecting duct to adapt to alkalosis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity insulin-activated receptor activity ATP binding integral component of plasma membrane insulin receptor complex protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway insulin receptor signaling pathway membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation male sex determination axon actin cytoskeleton reorganization receptor complex phosphatidylinositol 3-kinase binding insulin receptor substrate binding protein autophosphorylation anatomical structure development cellular response to alkaline pH uc008psy.1 uc008psy.2 uc008psy.3 
ENSMUST00000029712.5 Ntrk1 ENSMUST00000029712.5 neurotrophic tyrosine kinase, receptor, type 1 (from RefSeq NM_001033124.1) ENSMUST00000029712.1 ENSMUST00000029712.2 ENSMUST00000029712.3 ENSMUST00000029712.4 NM_001033124 NTRK1_MOUSE Q3UFB7 uc008psw.1 uc008psw.2 Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; The pro-survival signaling effect of NTRK1 in neurons requires its endocytosis into signaling early endosomes and its retrograde axonal transport. This is regulated by different proteins including CFL1, RAC1 and SORT1. NTF3 is unable to induce this signaling probably due to the lability of the NTF3-NTRK1 complex in endosomes. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. Regulated by NGFR. Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Homodimerization is induced by binding of a NGF dimer (By similarity). Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)- dependent manner. Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation. Interacts with SQSTM1; bridges NTRK1 to NGFR. Forms a ternary complex with NGFR and KIDINS220; this complex is affected by the expression levels of KIDINS220 and an increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts (phosphorylated upon activation by NGF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by NGF) with PLCG1; mediates PLCG1 phosphorylation and activation. Interacts (phosphorylated) with SH2B1 and SH2B2. Interacts with GRB2. Interacts with PIK3R1. Interacts with FRS2. Interacts with SORT1; may regulate NTRK1 anterograde axonal transport (By similarity). Interacts with SH2D1A; regulates NTRK1 (PubMed:16223723). Interacts with NRADD. Interacts with RAB7A. Interacts with PTPRS (By similarity). Interacts with USP36; USP36 does not deubiquitinate NTRK1 (By similarity). Interacts with GGA3 (By similarity). Cell membrane ; Single-pass type I membrane protein Early endosome membrane ; Single-pass type I membrane protein Late endosome membrane ; Single-pass type I membrane protein Recycling endosome membrane ; Single-pass type I membrane protein Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes. First detected at 13.5 dpc, a time coinciding with the requirement of sympathetic neurons for NGF. Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain. The transmembrane domain mediates interaction with KIDINS220. The extracellular domain mediates interaction with NGFR. Ligand-mediated autophosphorylation. Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at Tyr-499 mediates interaction and phosphorylation of SHC1. N-glycosylated. Ubiquitinated (PubMed:16113645). Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination by NEDD4L leads to degradation (By similarity). Ubiquitination regulates the internalization of the receptor (PubMed:16113645). Mice die early after birth due to severe sensory and sympathetic neuropathies characterized by extensive neuronal cell loss in trigeminal, sympathetic and dorsal root ganglia, as well as a decrease in the cholinergic basal forebrain projections to the hippocampus and cortex. There are for instance 35% fewer cells by 17.5 dpc in the superior cervical ganglion, a major component of the sympathetic system. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Sequence=BAE28644.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding positive regulation of protein phosphorylation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin receptor activity neurotrophin p75 receptor binding protein binding ATP binding cytoplasm endosome early endosome late endosome plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development axon guidance aging learning or memory circadian rhythm negative regulation of cell proliferation response to radiation cell surface nerve growth factor receptor activity programmed cell death involved in cell development positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase signaling response to activity membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation sensory perception of pain kinase binding olfactory nerve development cell differentiation B cell differentiation axon dendrite neuron projection development cytoplasmic vesicle response to nutrient levels early endosome membrane late endosome membrane macromolecular complex response to nicotine peptidyl-tyrosine autophosphorylation nerve growth factor signaling pathway mechanoreceptor differentiation response to drug identical protein binding protein homodimerization activity neuronal cell body positive regulation of programmed cell death neurotrophin binding receptor complex regulation of MAPK cascade positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of angiogenesis positive regulation of Ras protein signal transduction protein autophosphorylation neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway nerve growth factor binding sympathetic nervous system development neuron development response to axon injury detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity response to hydrostatic pressure response to electrical stimulus regulation of protein kinase B signaling positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic recycling endosome recycling endosome membrane Sertoli cell development innervation axonogenesis involved in innervation behavioral response to formalin induced pain positive regulation of ERK1 and ERK2 cascade cellular response to nicotine cellular response to growth factor stimulus negative regulation of neuron death cellular response to nerve growth factor stimulus uc008psw.1 uc008psw.2 
ENSMUST00000029717.4 Cd1d1 ENSMUST00000029717.4 CD1d1 antigen, transcript variant 1 (from RefSeq NM_007639.4) A0A0R4J090 A0A0R4J090_MOUSE Cd1d1 ENSMUST00000029717.1 ENSMUST00000029717.2 ENSMUST00000029717.3 NM_007639 uc012cre.1 uc012cre.2 uc012cre.3 uc012cre.4 Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein membrane integral component of membrane uc012cre.1 uc012cre.2 uc012cre.3 uc012cre.4 
ENSMUST00000029719.14 Dclk2 ENSMUST00000029719.14 doublecortin-like kinase 2, transcript variant 2 (from RefSeq NM_027539.5) DCLK2_MOUSE Dcamkl2 ENSMUST00000029719.1 ENSMUST00000029719.10 ENSMUST00000029719.11 ENSMUST00000029719.12 ENSMUST00000029719.13 ENSMUST00000029719.2 ENSMUST00000029719.3 ENSMUST00000029719.4 ENSMUST00000029719.5 ENSMUST00000029719.6 ENSMUST00000029719.7 ENSMUST00000029719.8 ENSMUST00000029719.9 NM_027539 Q1EDG7 Q1EDG8 Q4H483 Q4W8V1 Q6PGN3 Q8BUU0 Q8BX25 uc008prl.1 uc008prl.2 uc008prl.3 uc008prl.4 uc008prl.5 This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]. Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Binds to and stabilizes microtubules (By similarity). Interacts with MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK9/JNK2, PPP1R9B/NEURABIN-2 and actin. Cytoplasm, cytoskeleton Note=Colocalizes with microtubules. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q6PGN3-1; Sequence=Displayed; Name=2; IsoId=Q6PGN3-2; Sequence=VSP_012797; Name=3; Synonyms=alpha; IsoId=Q6PGN3-3; Sequence=VSP_038892, VSP_012797; Name=4; Synonyms=beta1; IsoId=Q6PGN3-4; Sequence=VSP_038892, VSP_038895, VSP_038896; Name=5; Synonyms=beta2; IsoId=Q6PGN3-5; Sequence=VSP_038892, VSP_012797, VSP_038895, VSP_038896; Name=6; IsoId=Q6PGN3-6; Sequence=VSP_038893, VSP_038894; Expressed in the central and peripheral nervous system including the brain, spinal cord, cranial and dorsal root ganglia and in the parasympathetic ganglia. Present in neurons, but not in glial cells, in most forebrain areas. Strong expression in the hippocampal CA1 pyramidal cell layer. Expressed in the photoreceptor sensory cilium complex and in eyes. Also detected in individual cells of the olfactory epithelium. At 17.5 dpc, predominantly expressed in the central nervous system, throughout the forebrain, midbrain, hindbrain, and the spinal cord. Expressed in the developing neocortex and at low levels in the ventricular zone, especially in the outer neuroblastic layer. In the developing retina, strongly expressed in the postmitotic inner neuroblastic layer. Also found in the developing ovary and, to a lower extent, throughout the kidney. The doublecortin domains are involved in the colocalization with microtubules. Autophosphorylated. Frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. nucleotide binding microtubule cytoskeleton organization protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm cytoskeleton protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation hippocampus development pyramidal neuron development intracellular signal transduction negative regulation of protein localization to nucleus microtubule uc008prl.1 uc008prl.2 uc008prl.3 uc008prl.4 uc008prl.5 
ENSMUST00000029722.7 Rps3a1 ENSMUST00000029722.7 ribosomal protein S3A1 (from RefSeq NM_016959.4) ENSMUST00000029722.1 ENSMUST00000029722.2 ENSMUST00000029722.3 ENSMUST00000029722.4 ENSMUST00000029722.5 ENSMUST00000029722.6 NM_016959 Q564F3 Q564F3_MOUSE RPS3A Rps3a Rps3a1 uc008prc.1 uc008prc.2 uc008prc.3 uc008prc.4 May play a role during erythropoiesis through regulation of transcription factor DDIT3. Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3. Cytoplasm Nucleus Nucleus, nucleolus Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Belongs to the eukaryotic ribosomal protein eS1 family. structural constituent of ribosome nucleus cytoplasm ribosome translation cytosolic small ribosomal subunit cell differentiation uc008prc.1 uc008prc.2 uc008prc.3 uc008prc.4 
ENSMUST00000029730.5 Chd1l ENSMUST00000029730.5 chromodomain helicase DNA binding protein 1-like, transcript variant 1 (from RefSeq NM_026539.3) CHD1L_MOUSE ENSMUST00000029730.1 ENSMUST00000029730.2 ENSMUST00000029730.3 ENSMUST00000029730.4 NM_026539 Q3TMX1 Q6P5C0 Q9CXF7 uc008qow.1 uc008qow.2 uc008qow.3 ATP-dependent chromatin remodeler that mediates chromatin- remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP- dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Adopts an inactive conformation in absence of DNA damage. Binding to poly-ADP-ribosylated histones activates the ATP- dependent chromatin remodeler activity. Interacts with nucleosomes; interacts with the acidic patch of histones. Interacts (via macro domain) with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated). Interacts with CIAO1. Nucleus Chromosome Note=Localizes at sites of DNA damage; recruited by histones H2B and H3 poly-ADP-ribosylated on 'Ser-6' and 'Ser-10', respectively (H2BS6ADPr and H3S10ADPr) by PARP1 or PARP2. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CXF7-1; Sequence=Displayed; Name=2; IsoId=Q9CXF7-2; Sequence=VSP_033343; The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites. Mediates auto-inhibition of ATPase activity by interacting with the N-terminal ATPase module, encompassing the helicase ATP-binding domain and helicase C-terminal domain. Binding to poly-ADP-ribosylated histones upon DNA damage releases the auto- inhibition by the macro domain and trigger ATPase activity. Does not bind monomeric ADP-ribose and mono-ADP-ribose fails to release the auto-inhibition of the ATPase module by the macro domain. Belongs to the SNF2/RAD54 helicase family. nucleotide binding DNA helicase activity helicase activity ATP binding nucleus nucleoplasm cytosol plasma membrane DNA repair chromatin remodeling cellular response to DNA damage stimulus hydrolase activity ATPase activity DNA duplex unwinding uc008qow.1 uc008qow.2 uc008qow.3 
ENSMUST00000029738.14 Gpr89 ENSMUST00000029738.14 G protein-coupled receptor 89, transcript variant 1 (from RefSeq NM_026229.5) ENSMUST00000029738.1 ENSMUST00000029738.10 ENSMUST00000029738.11 ENSMUST00000029738.12 ENSMUST00000029738.13 ENSMUST00000029738.2 ENSMUST00000029738.3 ENSMUST00000029738.4 ENSMUST00000029738.5 ENSMUST00000029738.6 ENSMUST00000029738.7 ENSMUST00000029738.8 ENSMUST00000029738.9 GPHR_MOUSE Gphr Gpr89 Gpr89a NM_026229 Q8BS95 Q9D455 uc008qom.1 uc008qom.2 uc008qom.3 Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (By similarity). Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (PubMed:32220963). Homotrimer (By similarity). Interacts with RABL3; the interaction stabilizes GPR89 (PubMed:32220963). Golgi apparatus membrane ; Multi-pass membrane protein Belongs to the Golgi pH regulator (TC 1.A.38) family. Golgi membrane voltage-gated ion channel activity Golgi apparatus ion transport voltage-gated anion channel activity protein transport inorganic anion transport membrane integral component of membrane Golgi-associated vesicle membrane Golgi cisterna membrane ion transmembrane transport regulation of ion transmembrane transport skin development intracellular pH reduction uc008qom.1 uc008qom.2 uc008qom.3 
ENSMUST00000029740.14 Rnf115 ENSMUST00000029740.14 ring finger protein 115 (from RefSeq NM_026406.3) ENSMUST00000029740.1 ENSMUST00000029740.10 ENSMUST00000029740.11 ENSMUST00000029740.12 ENSMUST00000029740.13 ENSMUST00000029740.2 ENSMUST00000029740.3 ENSMUST00000029740.4 ENSMUST00000029740.5 ENSMUST00000029740.6 ENSMUST00000029740.7 ENSMUST00000029740.8 ENSMUST00000029740.9 NM_026406 Q8R5A1 Q9D0C1 Q9D885 RN115_MOUSE Rnf115 Zfp364 Znf364 uc008qoe.1 uc008qoe.2 uc008qoe.3 uc008qoe.4 E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys- 48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence= Protein modification; protein ubiquitination. Interacts with RAB7A. Interacts with EGFR and FLT3. Cytoplasm, cytosol Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes. RING-type zinc finger-dependent and E2-dependent autoubiquitination. ubiquitin-protein transferase activity protein binding cytoplasm cytosol protein ubiquitination transferase activity negative regulation of epidermal growth factor receptor signaling pathway ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway metal ion binding protein autoubiquitination ubiquitin protein ligase activity protein K63-linked ubiquitination protein K48-linked ubiquitination uc008qoe.1 uc008qoe.2 uc008qoe.3 uc008qoe.4 
ENSMUST00000029741.9 Polr3c ENSMUST00000029741.9 polymerase (RNA) III (DNA directed) polypeptide C (from RefSeq NM_028925.2) ENSMUST00000029741.1 ENSMUST00000029741.2 ENSMUST00000029741.3 ENSMUST00000029741.4 ENSMUST00000029741.5 ENSMUST00000029741.6 ENSMUST00000029741.7 ENSMUST00000029741.8 NM_028925 Polr3c Q8R0I2 Q9D483 RPC3_MOUSE uc008qoa.1 uc008qoa.2 uc008qoa.3 uc008qoa.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer, coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (By similarity). Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3- POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Directly interacts with POLR3G/RPC7 and POLR3GL. Directly interacts with POLR3F/RPC6. Interacts with GTF3C4. As part of the RNA polymerase III complex, interacts with PKP2. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D483-1; Sequence=Displayed; Name=2; IsoId=Q9D483-2; Sequence=VSP_010678, VSP_010679; Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family. immune system process DNA binding single-stranded DNA binding DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm DNA-directed RNA polymerase III complex transcription, DNA-templated transcription from RNA polymerase III promoter transferase activity nucleotidyltransferase activity positive regulation of interferon-beta production innate immune response positive regulation of innate immune response defense response to virus RNA polymerase III activity uc008qoa.1 uc008qoa.2 uc008qoa.3 uc008qoa.4 
ENSMUST00000029748.8 Fcgr1 ENSMUST00000029748.8 Fc receptor, IgG, high affinity I (from RefSeq NM_010186.5) ENSMUST00000029748.1 ENSMUST00000029748.2 ENSMUST00000029748.3 ENSMUST00000029748.4 ENSMUST00000029748.5 ENSMUST00000029748.6 ENSMUST00000029748.7 FCGR1_MOUSE Fcg1 NM_010186 P26151 uc008qmr.1 uc008qmr.2 High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Interacts with FCERG1; forms a functional signaling complex (By similarity). Interacts with FLNA; prevents FCGR1A degradation (By similarity). Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN (By similarity). Cell membrane; Single-pass type I membrane protein. Note=Stabilized at the cell membrane through interaction with FCER1G. Macrophage-specific. N-glycosylated. Phosphorylated on serine residues. According to PubMed:11911823, mice display altered endocytosis of monomeric IgG and impaired antibody-dependent killing of cells by macrophage. Antigen presentation is also affected and those mice develop only reduced inflammatory responses. An increased in IgG responses is also detected associated with an increased number of antibody-forming cells. PubMed:11911824, also reported that a variety of IgG2a-immune complex-dependent immune functions like protection against bacterial infection were impaired. Belongs to the immunoglobulin superfamily. FCGR1 family. It is uncertain whether Met-1 or Met-10 is the initiator. antibody-dependent cellular cytotoxicity positive regulation of type IIa hypersensitivity positive regulation of type III hypersensitivity immune system process plasma membrane receptor-mediated endocytosis phagocytosis, recognition phagocytosis, engulfment cell surface receptor signaling pathway response to bacterium external side of plasma membrane membrane integral component of membrane IgG receptor activity IgG binding antigen processing and presentation of exogenous antigen leukotriene receptor binding Fc-gamma receptor signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I defense response to bacterium innate immune response membrane raft positive regulation of phagocytosis regulation of immune response positive regulation of phagocytosis, engulfment positive regulation of protein tyrosine kinase activity uc008qmr.1 uc008qmr.2 
ENSMUST00000029752.15 Tars2 ENSMUST00000029752.15 threonyl-tRNA synthetase 2, mitochondrial (putative), transcript variant 1 (from RefSeq NM_027931.3) B2RW19 ENSMUST00000029752.1 ENSMUST00000029752.10 ENSMUST00000029752.11 ENSMUST00000029752.12 ENSMUST00000029752.13 ENSMUST00000029752.14 ENSMUST00000029752.2 ENSMUST00000029752.3 ENSMUST00000029752.4 ENSMUST00000029752.5 ENSMUST00000029752.6 ENSMUST00000029752.7 ENSMUST00000029752.8 ENSMUST00000029752.9 NM_027931 Q3UQ84 Q9D0D6 SYTM_MOUSE Tarsl1 uc008qkr.1 uc008qkr.2 uc008qkr.3 uc008qkr.4 Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain. Reaction=ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L- threonyl-tRNA(Thr); Xref=Rhea:RHEA:24624, Rhea:RHEA-COMP:9670, Rhea:RHEA-COMP:9704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57926, ChEBI:CHEBI:78442, ChEBI:CHEBI:78534, ChEBI:CHEBI:456215; EC=6.1.1.3; Evidence=; Homodimer. Mitochondrion matrix Belongs to the class-II aminoacyl-tRNA synthetase family. nucleotide binding aminoacyl-tRNA editing activity aminoacyl-tRNA ligase activity threonine-tRNA ligase activity ATP binding cytoplasm mitochondrion mitochondrial matrix translation tRNA aminoacylation for protein translation threonyl-tRNA aminoacylation ligase activity protein homodimerization activity tRNA aminoacylation uc008qkr.1 uc008qkr.2 uc008qkr.3 uc008qkr.4 
ENSMUST00000029753.14 Ecm1 ENSMUST00000029753.14 extracellular matrix protein 1, transcript variant 32 (from RefSeq NM_001409948.1) ENSMUST00000029753.1 ENSMUST00000029753.10 ENSMUST00000029753.11 ENSMUST00000029753.12 ENSMUST00000029753.13 ENSMUST00000029753.2 ENSMUST00000029753.3 ENSMUST00000029753.4 ENSMUST00000029753.5 ENSMUST00000029753.6 ENSMUST00000029753.7 ENSMUST00000029753.8 ENSMUST00000029753.9 Ecm1 F8WI14 F8WI14_MOUSE NM_001409948 uc008qkp.1 uc008qkp.2 uc008qkp.3 uc008qkp.4 extracellular region extracellular space signal transduction uc008qkp.1 uc008qkp.2 uc008qkp.3 uc008qkp.4 
ENSMUST00000029754.13 Hormad1 ENSMUST00000029754.13 HORMA domain containing 1, transcript variant 5 (from RefSeq NM_001373886.1) ENSMUST00000029754.1 ENSMUST00000029754.10 ENSMUST00000029754.11 ENSMUST00000029754.12 ENSMUST00000029754.2 ENSMUST00000029754.3 ENSMUST00000029754.4 ENSMUST00000029754.5 ENSMUST00000029754.6 ENSMUST00000029754.7 ENSMUST00000029754.8 ENSMUST00000029754.9 HORM1_MOUSE Hormad1 NM_001373886 Nohma Q9CUF3 Q9D473 Q9D5T7 uc008qkd.1 uc008qkd.2 uc008qkd.3 uc008qkd.4 Plays a key role in meiotic progression (PubMed:19686734, PubMed:21079677, PubMed:21478856). Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends (PubMed:19686734, PubMed:21079677). Promotes synaptonemal-complex formation independently of its role in homology search (PubMed:19686734, PubMed:21079677). Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (PubMed:21478856). Interacts with HORMAD2 (PubMed:22549958). Interacts with IHO1 (PubMed:27723721). [Isoform 1]: Nucleus Chromosome te=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis (PubMed:19851446, PubMed:19686734, PubMed:27723721). Accumulates on the chromosomes during the leptotene to zygotene stages of meiotic prophase I (PubMed:19851446, PubMed:19686734, PubMed:27723721). As germ cells progress into the pachytene stage, disappears from the synapsed chromosomal regions (PubMed:19851446, PubMed:19686734, PubMed:27723721). Once the chromosomes desynapse during the diplotene stage, it again accumulates on the chromosome axis of the desynapsed homologs (PubMed:19851446, PubMed:19686734, PubMed:27723721). TRIP13 is required for depletion from synapsed chromosomes (PubMed:19851446). The expression of the phosphorylated form at Ser-375 is restricted to unsynapsed chromosomal regions (PubMed:22346761). [Isoform 2]: Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=HORMAD1L; IsoId=Q9D5T7-1; Sequence=Displayed; Name=2; Synonyms=HORMAD1S; IsoId=Q9D5T7-2; Sequence=VSP_024604; Specifically expressed in meiotic germ cells. Expressed in spermatocytes from P10 to adulthood. Expressed in oocytes from 12.5 dpc to P9. Primarily detected in spermatocytes and less in spermatids or spermatogonia. Abundant in the nuclei of pachytene and zygotene cells. Also detected in nuclei of diplotene cells (at protein level). Phosphorylated at Ser-375 in a SPO11-dependent manner. Mice develop normally without obvious somatic defects but males and females are sterile. Although spermatocytes are present in testis tubules at epithelial cycle stage III-IV, they undergo apoptosis by the end of stage IV, and post-meiotic cells are not found in testes, suggesting that spermatocytes are eliminated at a stage equivalent to mid-pachytene. In females, ovarian development is grossly normal, eggs fertilize and embryonic development arrests at blastocyst stage due to aneuploidy. condensed nuclear chromosome synaptonemal complex blastocyst development protein binding nucleus chromosome cytoplasm synapsis synaptonemal complex assembly spermatogenesis cell differentiation meiotic DNA double-strand break formation oogenesis meiotic sister chromatid cohesion meiotic cell cycle meiotic recombination checkpoint regulation of homologous chromosome segregation uc008qkd.1 uc008qkd.2 uc008qkd.3 uc008qkd.4 
ENSMUST00000029759.16 Mettl14 ENSMUST00000029759.16 methyltransferase 14, N6-adenosine-methyltransferase subunit (from RefSeq NM_201638.2) ENSMUST00000029759.1 ENSMUST00000029759.10 ENSMUST00000029759.11 ENSMUST00000029759.12 ENSMUST00000029759.13 ENSMUST00000029759.14 ENSMUST00000029759.15 ENSMUST00000029759.2 ENSMUST00000029759.3 ENSMUST00000029759.4 ENSMUST00000029759.5 ENSMUST00000029759.6 ENSMUST00000029759.7 ENSMUST00000029759.8 ENSMUST00000029759.9 Kiaa1627 MET14_MOUSE NM_201638 Q3UIK4 Q6ZPL2 Q80UR9 uc008rfi.1 uc008rfi.2 uc008rfi.3 uc008rfi.4 The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24394384, PubMed:28965759). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (By similarity). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (By similarity). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (PubMed:24394384). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency- promoting transcripts results in transcript destabilization (PubMed:24394384). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (PubMed:28914256). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (PubMed:28965759). Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase (By similarity). Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:29535189, PubMed:29547716). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:29535189, PubMed:29547716). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29535189, PubMed:29547716). Q3UIK4; Q8C3P7: Mettl3; NbExp=2; IntAct=EBI-16089028, EBI-8311763; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UIK4-1; Sequence=Displayed; Name=2; IsoId=Q3UIK4-2; Sequence=VSP_032406; Expressed in testis (PubMed:28914256). Highly expressed in radial glial cells during embryonic cortical neurogenesis (PubMed:28965759). Conditional knockout mice lacking Mettl3 and Mettl14 in germ cells show impaired spermatogenesis, leading to male infertility (PubMed:28914256). Conditional knockout mice lacking Mettl14 in the developing nervous system die by postnatal day 25 due to protracted cell-cycle progression of cortical neural progenitor cells and reduced differentiation of radial glial cells during embryonic cortical neurogenesis (PubMed:28965759). Belongs to the MT-A70-like family. The ability of METTL14 to have catalytic activity is unclear and a number of experimental evidence suggests that it has no methyltransferase activity by itself. According to some reports, has some methyltransferase activity in vitro (PubMed:24394384). However, other studies showed that METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. 3D- structure studies showed that METTL14 contains a degenerate active site that is unable to accommodate donor and acceptor substrates. Sequence=BAC98219.1; Type=Erroneous initiation; Evidence=; mRNA splicing, via spliceosome RNA methylation RNA binding mRNA binding protein binding nucleus nucleoplasm mRNA catabolic process spermatogenesis mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity stem cell population maintenance forebrain radial glial cell differentiation cell differentiation MIS complex gliogenesis mRNA destabilization mRNA methylation S-adenosyl-L-methionine binding uc008rfi.1 uc008rfi.2 uc008rfi.3 uc008rfi.4 
ENSMUST00000029761.14 Myoz2 ENSMUST00000029761.14 myozenin 2, transcript variant 1 (from RefSeq NM_021503.2) ENSMUST00000029761.1 ENSMUST00000029761.10 ENSMUST00000029761.11 ENSMUST00000029761.12 ENSMUST00000029761.13 ENSMUST00000029761.2 ENSMUST00000029761.3 ENSMUST00000029761.4 ENSMUST00000029761.5 ENSMUST00000029761.6 ENSMUST00000029761.7 ENSMUST00000029761.8 ENSMUST00000029761.9 MYOZ2_MOUSE Myoz2 NM_021503 Q9JJW5 uc008rfe.1 uc008rfe.2 uc008rfe.3 uc008rfe.4 Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Interacts via its C-terminus with spectrin repeats 3 and 4 of ACTN2. Interacts with ACTN1, LDB3, MYOT and PPP3CA (By similarity). Cytoplasm, myofibril, sarcomere, Z line Note=Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle. Expressed specifically in heart and skeletal muscle. In skeletal muscle, localized to the soleus and plantaris muscles, which are predominantly composed of slow-twitch fibers. At 9.5 dpc, expressed weakly in heart. Higher levels of expression detected at 12.5 dpc and 15.5 dpc in both cardiac and skeletal muscle. Belongs to the myozenin family. negative regulation of transcription from RNA polymerase II promoter actin binding cytoplasm skeletal muscle tissue development actin cytoskeleton Z disc telethonin binding skeletal muscle fiber adaptation sarcomere organization FATZ binding negative regulation of calcineurin-NFAT signaling cascade uc008rfe.1 uc008rfe.2 uc008rfe.3 uc008rfe.4 
ENSMUST00000029766.9 Bcar3 ENSMUST00000029766.9 breast cancer anti-estrogen resistance 3, transcript variant 1 (from RefSeq NM_013867.3) And34 BCAR3_MOUSE ENSMUST00000029766.1 ENSMUST00000029766.2 ENSMUST00000029766.3 ENSMUST00000029766.4 ENSMUST00000029766.5 ENSMUST00000029766.6 ENSMUST00000029766.7 ENSMUST00000029766.8 NM_013867 Q3TNC9 Q3UP10 Q9QZK2 uc008req.1 uc008req.2 uc008req.3 uc008req.4 uc008req.5 Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:12517963). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:10896938). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (PubMed:25499443). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (PubMed:25499443). Regulates EGF-induced DNA synthesis (By similarity). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (PubMed:19365570). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (PubMed:22801373). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (PubMed:22801373). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (PubMed:10896938). However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity). Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain) and SRC; the formation of the complex is dependent on integrin mediated-tyrosine phosphorylation of PTPRA (PubMed:22801373). Within the complex, interacts (via SH2 domain) with PTPRA (when phosphorylated on 'Tyr-825') (PubMed:22801373). Interacts (via Ras-GEF domain) with BCAR1 (PubMed:10438950, PubMed:10896938, PubMed:12517963). Interacts (via Ras-GEF domain) with NEDD9 (PubMed:12517963, PubMed:19103205). Interacts with PTK2B/FAK1 (PubMed:10896938). Interacts with PTPN1. Interacts (via SH2 domain) with EGFR (when tyrosine-phosphorylated) (By similarity). Cytoplasm Cell junction, focal adhesion Note=Localization to focal adhesions depends on interaction with PTPRA. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QZK2-1; Sequence=Displayed; Name=2; IsoId=Q9QZK2-2; Sequence=VSP_017815; Abundantly expressed in the lung and brain, with lower expression in splenic lymphocytes and liver (at protein level) (PubMed:19365570). Expressed in splenic lymphocytes (at protein level) (PubMed:19365570). Expressed in the lymph node cortical region, periphery of the splenic white pulp and in alveolar lung fibroblasts (PubMed:19365570). Expressed in epithelial cells in the lens equatorial region and early stage nucleated cortical lens fiber cells (PubMed:19365570). Expressed in the thymus (PubMed:10438950). Expressed in B-cells (PubMed:12517963). Up-regulated by IL1A and LTA, in thymus cortical reticular cell lines. The SH2 domain mediates interaction with tyrosine- phosphorylated proteins (PubMed:10896938, PubMed:22801373). However, not involved in the binding to phosphorylated BCAR1 (PubMed:10896938). Required for cell cycle progression in response to INS/insulin (By similarity). Required for regulation of EGF-induced DNA synthesis (By similarity). The Ras-GEF domain appears to adopt a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is probably required for interaction with BCAR1. Phosphorylated on tyrosine residues. Knockout mice are generally normal and viable (PubMed:19365570). Retinal white circular lesions in anterior chamber derived from the lens cortex (PubMed:19365570). Retinal lens is partially opaque and irregular in structure, with rupture leading to cortical lens fragments floating in the aqueous humor (PubMed:19365570). Abnormally deep anterior chamber with anterior synechiae, ectropion uveae, mild to moderate retinal ganglion loss, and a small pigmented pre-retinal membrane overlying the optic nerve (PubMed:19365570). Reduced phosphorylation of AKT1 and BCAR1 in lens epithelial cells (PubMed:19365570). Retinal lens abnormalities develop progressively postnatally; at postnatal day 3 (P3) there is anterior lens vacuolization and liquefaction of lens cortical fibers (PubMed:19365570). At P24 there is evidence of extensive lens cortex vacuolation and early lens extrusion, progressing to extrusion of lens cortical material at P33 (PubMed:19365570). The guanine nucleotide exchange factor (GEF) activity is controversial. One study showed GEF activity towards RALA, RAP1A and RRAS (PubMed:10896938). However, in another study, a construct containing only the Ras-GEF domain lacks GEF activity towards RAP1 (By similarity). lens morphogenesis in camera-type eye guanyl-nucleotide exchange factor activity signal transduction small GTPase mediated signal transduction positive regulation of peptidyl-serine phosphorylation uc008req.1 uc008req.2 uc008req.3 uc008req.4 uc008req.5 
ENSMUST00000029769.14 Gclm ENSMUST00000029769.14 glutamate-cysteine ligase, modifier subunit (from RefSeq NM_008129.4) ENSMUST00000029769.1 ENSMUST00000029769.10 ENSMUST00000029769.11 ENSMUST00000029769.12 ENSMUST00000029769.13 ENSMUST00000029769.2 ENSMUST00000029769.3 ENSMUST00000029769.4 ENSMUST00000029769.5 ENSMUST00000029769.6 ENSMUST00000029769.7 ENSMUST00000029769.8 ENSMUST00000029769.9 Gclm NM_008129 Q4FJZ6 Q4FJZ6_MOUSE uc008reo.1 uc008reo.2 uc008reo.3 uc008reo.4 Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. Heterodimer of a catalytic heavy chain and a regulatory light chain. Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily. glutamate-cysteine ligase activity glutamate metabolic process glutathione biosynthetic process response to oxidative stress aging response to nutrient response to activity glutamate-cysteine ligase complex glutamate-cysteine ligase catalytic subunit binding positive regulation of glutamate-cysteine ligase activity cellular response to hepatocyte growth factor stimulus hepatic stellate cell activation response to drug negative regulation of neuron apoptotic process cellular response to fibroblast growth factor stimulus response to human chorionic gonadotropin protein heterodimerization activity response to nitrosative stress cellular response to glucose stimulus cellular response to follicle-stimulating hormone stimulus cellular response to thyroxine stimulus regulation of blood vessel diameter uc008reo.1 uc008reo.2 uc008reo.3 uc008reo.4 
ENSMUST00000029770.8 Abcd3 ENSMUST00000029770.8 ATP-binding cassette, sub-family D member 3, transcript variant 1 (from RefSeq NM_008991.4) ABCD3_MOUSE ENSMUST00000029770.1 ENSMUST00000029770.2 ENSMUST00000029770.3 ENSMUST00000029770.4 ENSMUST00000029770.5 ENSMUST00000029770.6 ENSMUST00000029770.7 NM_008991 P55096 Pmp70 Pxmp1 uc008reg.1 uc008reg.2 uc008reg.3 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009119.1, AK004660.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long- chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched- chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities (By similarity). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:25168382). Reaction=a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+); Xref=Rhea:RHEA:67072, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950, ChEBI:CHEBI:138261; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67073; Evidence=; Reaction=a very long-chain fatty acid(in) + ATP + H2O = a very long- chain fatty acid(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:67080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58950, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67081; Evidence=; Reaction=a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H(+); Xref=Rhea:RHEA:67680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67681; Evidence=; Reaction=a long-chain fatty acid(in) + ATP + H2O = a long-chain fatty acid(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:67684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57560, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67685; Evidence=; Reaction=H2O + pristanoyl-CoA = 2,6,10,14-tetramethylpentadecanoate + CoA + H(+); Xref=Rhea:RHEA:40415, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:77250, ChEBI:CHEBI:77268; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40416; Evidence=; Reaction=2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O = 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:67688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:77268, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67689; Evidence=; Reaction=H2O + hexadecanedioyl-CoA = CoA + H(+) + hexadecanedioate; Xref=Rhea:RHEA:67696, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:76276, ChEBI:CHEBI:77085; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67697; Evidence=; Reaction=ATP + H2O + hexadecanedioate(in) = ADP + H(+) + hexadecanedioate(out) + phosphate; Xref=Rhea:RHEA:67692, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:76276, ChEBI:CHEBI:456216; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+); Xref=Rhea:RHEA:67712, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58562, ChEBI:CHEBI:73862; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67713; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:67708, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58562, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67709; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+); Xref=Rhea:RHEA:67700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:74298, ChEBI:CHEBI:77016; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67701; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:67704, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:77016, ChEBI:CHEBI:456216; Evidence=; Homodimers. Can form heterodimers with ABCD1 and ABCD2. Dimerization is necessary to form an active transporter. Interacts with PEX19; mediates the targeting of ABCD3 to peroxisomes. Peroxisome membrane ; Multi-pass membrane protein Ubiquitinated by PEX2 during pexophagy in response to starvation, leading to its degradation. Animals show normal activity and have no obvious malformations. However, necroscopy show increased liver size compared to controls, and fibroblasts show reduced numbers of enlarged peroxisomes. They show however a defect in bile acid biosynthesis and they have impaired beta-oxidation of the branched-chain pristanic and phytanic fatty acids on a phytol-loaded diet. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. nucleotide binding long-chain fatty acid transporter activity protein binding ATP binding mitochondrion mitochondrial inner membrane peroxisome peroxisomal membrane peroxisomal matrix fatty acid biosynthetic process fatty acid beta-oxidation peroxisome organization response to organic cyclic compound peroxisomal long-chain fatty acid import membrane integral component of membrane ATPase activity response to drug ATPase activity, coupled to transmembrane movement of substances very long-chain fatty acid catabolic process protein homodimerization activity intracellular membrane-bounded organelle protein self-association transmembrane transport uc008reg.1 uc008reg.2 uc008reg.3 
ENSMUST00000029771.13 F3 ENSMUST00000029771.13 coagulation factor III (from RefSeq NM_010171.3) A0A0R4J088 A0A0R4J088_MOUSE ENSMUST00000029771.1 ENSMUST00000029771.10 ENSMUST00000029771.11 ENSMUST00000029771.12 ENSMUST00000029771.2 ENSMUST00000029771.3 ENSMUST00000029771.4 ENSMUST00000029771.5 ENSMUST00000029771.6 ENSMUST00000029771.7 ENSMUST00000029771.8 ENSMUST00000029771.9 F3 NM_010171 uc008ree.1 uc008ree.2 uc008ree.3 uc008ree.4 This gene encodes a membrane-bound glycoprotein that forms the primary physiological initiator of the blood coagulation process following vascular damage. The encoded protein binds to coagulation factor VIIa and the ensuing complex catalyzes the proteolytic activation of coagulation factors IX and X. Mice lacking encoded protein die in utero resulting from massive hemorrhaging in both extraembryonic and embryonic vessels. A severe deficiency of the encoded protein in mice results in impaired uterine homeostasis, shorter life spans due to spontaneous fatal hemorrhages and cardiac fibrosis. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024886.1, BC016397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. Membrane ; Single- pass type I membrane protein Belongs to the tissue factor family. blood coagulation membrane integral component of membrane uc008ree.1 uc008ree.2 uc008ree.3 uc008ree.4 
ENSMUST00000029773.13 Cnn3 ENSMUST00000029773.13 calponin 3, acidic (from RefSeq NM_028044.2) CNN3_MOUSE ENSMUST00000029773.1 ENSMUST00000029773.10 ENSMUST00000029773.11 ENSMUST00000029773.12 ENSMUST00000029773.2 ENSMUST00000029773.3 ENSMUST00000029773.4 ENSMUST00000029773.5 ENSMUST00000029773.6 ENSMUST00000029773.7 ENSMUST00000029773.8 ENSMUST00000029773.9 NM_028044 Q3TW23 Q9DAW9 uc008rdy.1 uc008rdy.2 uc008rdy.3 Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). Belongs to the calponin family. actin binding protein binding calmodulin binding cytosol microtubule binding postsynaptic density actin cytoskeleton dendrite epithelial cell differentiation actomyosin structure organization negative regulation of ATPase activity neuronal cell body dendritic spine uc008rdy.1 uc008rdy.2 uc008rdy.3 
ENSMUST00000029777.14 Tlcd4 ENSMUST00000029777.14 TLC domain containing 4, transcript variant 2 (from RefSeq NM_178936.4) ENSMUST00000029777.1 ENSMUST00000029777.10 ENSMUST00000029777.11 ENSMUST00000029777.12 ENSMUST00000029777.13 ENSMUST00000029777.2 ENSMUST00000029777.3 ENSMUST00000029777.4 ENSMUST00000029777.5 ENSMUST00000029777.6 ENSMUST00000029777.7 ENSMUST00000029777.8 ENSMUST00000029777.9 NM_178936 Q8CGF5 Q9D4Q8 TLCD4_MOUSE Tmem56 uc008rdw.1 uc008rdw.2 uc008rdw.3 uc008rdw.4 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CGF5-1; Sequence=Displayed; Name=2; IsoId=Q8CGF5-2; Sequence=VSP_025144, VSP_025145; Belongs to the TLCD4 family. It is uncertain whether Met-1 or Met-14 is the initiator. molecular_function cellular_component biological_process membrane integral component of membrane uc008rdw.1 uc008rdw.2 uc008rdw.3 uc008rdw.4 
ENSMUST00000029780.12 Ptbp2 ENSMUST00000029780.12 polypyrimidine tract binding protein 2, transcript variant 1 (from RefSeq NM_019550.2) Brptb ENSMUST00000029780.1 ENSMUST00000029780.10 ENSMUST00000029780.11 ENSMUST00000029780.2 ENSMUST00000029780.3 ENSMUST00000029780.4 ENSMUST00000029780.5 ENSMUST00000029780.6 ENSMUST00000029780.7 ENSMUST00000029780.8 ENSMUST00000029780.9 NM_019550 Nptb PTBP2_MOUSE Ptbp2 Q7TNW7 Q91Z31 Q9CUW2 Q9QYC2 Q9R0V9 uc008rdk.1 uc008rdk.2 uc008rdk.3 RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing (PubMed:10829067, PubMed:30638744). May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection (PubMed:10829067). In addition to its function in pre-mRNA splicing, also plays a role in the regulation of translation (PubMed:11726525). Monomer. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Part of a ternary complex containing KHSRP and HNRPH1 (By similarity). Interacts with NOVA1; the interaction is direct (PubMed:10829067). Interacts with NOVA2; the interaction is direct (PubMed:10829067). Q91Z31; Q9WVE0: Aicda; NbExp=4; IntAct=EBI-647632, EBI-3835567; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91Z31-1; Sequence=Displayed; Name=2; IsoId=Q91Z31-2; Sequence=VSP_018019; Mainly expressed in brain, including cerebellum, brainstem, spinal cord, and hypothalamus. Also expressed in the peripheral nervous system and neural crest derivatives, including the dorsal root and trigeminal ganglia, the cochlear spiral and intestinal ganglion cells, and the adrenal medulla. Also detected to a lower extent in testis, heart, liver, lung, skeletal muscle and thymus (at protein level). Expressed in whole brain tissues from 11.5 dpc to adulthood. nucleic acid binding RNA binding mRNA binding protein binding nucleus spliceosomal complex mRNA splice site selection mRNA processing RNA splicing spinal cord development cerebellum development growth cone negative regulation of RNA splicing neuronal cell body regulation of neural precursor cell proliferation uc008rdk.1 uc008rdk.2 uc008rdk.3 
ENSMUST00000029784.10 Celf3 ENSMUST00000029784.10 CUGBP, Elav-like family member 3, transcript variant 2 (from RefSeq NM_172434.4) CELF3_MOUSE ENSMUST00000029784.1 ENSMUST00000029784.2 ENSMUST00000029784.3 ENSMUST00000029784.4 ENSMUST00000029784.5 ENSMUST00000029784.6 ENSMUST00000029784.7 ENSMUST00000029784.8 ENSMUST00000029784.9 NM_172434 Q6PFH2 Q8CIN6 Tnrc4 uc008qgo.1 uc008qgo.2 uc008qgo.3 uc008qgo.4 RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CIN6-1; Sequence=Displayed; Name=2; IsoId=Q8CIN6-2; Sequence=VSP_026826, VSP_026827; Belongs to the CELF/BRUNOL family. regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding nucleus cytoplasm mRNA splice site selection mRNA processing spermatogenesis RNA splicing nuclear body flagellated sperm motility nuclear body organization positive regulation of mRNA splicing, via spliceosome 7SK snRNA binding ncRNA transcription ribonucleoprotein complex uc008qgo.1 uc008qgo.2 uc008qgo.3 uc008qgo.4 
ENSMUST00000029785.4 Riiad1 ENSMUST00000029785.4 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1, transcript variant 1 (from RefSeq NM_025506.2) ENSMUST00000029785.1 ENSMUST00000029785.2 ENSMUST00000029785.3 NM_025506 Q3KNY5 Q9D7J0 RIAD1_MOUSE uc008qgk.1 uc008qgk.2 uc008qgk.3 Abundant in tissues rich in highly ciliated cells, such as testis, trachea and olfactory epithelium. It is uncertain whether Met-1 or Met-28 is the initiator. Sequence=AAI07022.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; cellular_component biological_process uc008qgk.1 uc008qgk.2 uc008qgk.3 
ENSMUST00000029786.14 Mrpl9 ENSMUST00000029786.14 mitochondrial ribosomal protein L9, transcript variant 1 (from RefSeq NM_030116.3) ENSMUST00000029786.1 ENSMUST00000029786.10 ENSMUST00000029786.11 ENSMUST00000029786.12 ENSMUST00000029786.13 ENSMUST00000029786.2 ENSMUST00000029786.3 ENSMUST00000029786.4 ENSMUST00000029786.5 ENSMUST00000029786.6 ENSMUST00000029786.7 ENSMUST00000029786.8 ENSMUST00000029786.9 NM_030116 Q3TSJ0 Q8BQZ2 Q99N94 RM09_MOUSE uc008qgj.1 uc008qgj.2 uc008qgj.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the bacterial ribosomal protein bL9 family. molecular_function structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation biological_process uc008qgj.1 uc008qgj.2 uc008qgj.3 
ENSMUST00000029794.11 Them5 ENSMUST00000029794.11 thioesterase superfamily member 5 (from RefSeq NM_025416.3) Acot15 ENSMUST00000029794.1 ENSMUST00000029794.10 ENSMUST00000029794.2 ENSMUST00000029794.3 ENSMUST00000029794.4 ENSMUST00000029794.5 ENSMUST00000029794.6 ENSMUST00000029794.7 ENSMUST00000029794.8 ENSMUST00000029794.9 NM_025416 Q9CQJ0 Q9CTI2 THEM5_MOUSE uc008qfv.1 uc008qfv.2 uc008qfv.3 Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (By similarity). Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin (PubMed:22586271). Required for normal mitochondrial function (PubMed:22586271). Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+); Xref=Rhea:RHEA:40143, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40144; Evidence=; Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40140; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+); Xref=Rhea:RHEA:40131, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40132; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)- eicosatetraenoate + CoA + H(+); Xref=Rhea:RHEA:40151, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40152; Evidence=; Reaction=H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate; Xref=Rhea:RHEA:30139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30140; Evidence=; Homodimer. Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQJ0-1; Sequence=Displayed; Name=2; IsoId=Q9CQJ0-2; Sequence=VSP_024556; With increasing age, mice develop fatty liver, due to impaired mitochondrial fatty acid metabolism, and impaired remodeling of the mitochondrial lipid cardiolipin. Mitochondria contain increased levels of monolysocardiolipin, and decreased levels of linoleic and linolenic acid. The altered fatty acid metabolism leads to decreased mitochondrial beta-oxidation and ketone body formation. Mitochondria show abnormal, elongated morphology, and their function is impaired. Belongs to the THEM4/THEM5 thioesterase family. mitochondrion mitochondrial matrix lipid metabolic process fatty acid metabolic process palmitoyl-CoA hydrolase activity hydrolase activity long-chain fatty-acyl-CoA metabolic process cardiolipin acyl-chain remodeling uc008qfv.1 uc008qfv.2 uc008qfv.3 
ENSMUST00000029795.10 Rorc ENSMUST00000029795.10 RAR-related orphan receptor gamma, transcript variant 1 (from RefSeq NM_011281.4) A0A0R4J096 A0A0R4J096_MOUSE ENSMUST00000029795.1 ENSMUST00000029795.2 ENSMUST00000029795.3 ENSMUST00000029795.4 ENSMUST00000029795.5 ENSMUST00000029795.6 ENSMUST00000029795.7 ENSMUST00000029795.8 ENSMUST00000029795.9 NM_011281 Rorc uc008qfy.1 uc008qfy.2 uc008qfy.3 uc008qfy.4 uc008qfy.5 uc008qfy.6 Nucleus Belongs to the nuclear hormone receptor family. NR1 subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding nucleus regulation of transcription, DNA-templated circadian rhythm oxysterol binding zinc ion binding nuclear body intracellular receptor signaling pathway cellular response to sterol steroid hormone mediated signaling pathway sequence-specific DNA binding metal ion binding transcription factor activity, direct ligand regulated sequence-specific DNA binding uc008qfy.1 uc008qfy.2 uc008qfy.3 uc008qfy.4 uc008qfy.5 uc008qfy.6 
ENSMUST00000029800.9 Tspan5 ENSMUST00000029800.9 tetraspanin 5, transcript variant 1 (from RefSeq NM_019571.5) ENSMUST00000029800.1 ENSMUST00000029800.2 ENSMUST00000029800.3 ENSMUST00000029800.4 ENSMUST00000029800.5 ENSMUST00000029800.6 ENSMUST00000029800.7 ENSMUST00000029800.8 NM_019571 O60628 O60746 P62080 Q9JLY1 TSN5_MOUSE Tm4sf9 uc008rnp.1 uc008rnp.2 uc008rnp.3 uc008rnp.4 Regulates ADAM10 maturation and trafficking to the cell surface (PubMed:23035126). Promotes ADAM10-mediated cleavage of CD44 (By similarity). Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:23035126). Promotes ADAM10-mediated cleavage of CD44. Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration (By similarity). Interacts with ADAM10; the interaction influences ADAM10 substrate specificity, endocytosis and turnover. Cell membrane ; Multi-pass membrane protein Palmitoylated. Belongs to the tetraspanin (TM4SF) family. plasma membrane integral component of plasma membrane membrane integral component of membrane enzyme binding positive regulation of Notch signaling pathway protein maturation protein localization to plasma membrane uc008rnp.1 uc008rnp.2 uc008rnp.3 uc008rnp.4 
ENSMUST00000029803.12 Eif4e ENSMUST00000029803.12 eukaryotic translation initiation factor 4E, transcript variant 1 (from RefSeq NM_007917.4) ENSMUST00000029803.1 ENSMUST00000029803.10 ENSMUST00000029803.11 ENSMUST00000029803.2 ENSMUST00000029803.3 ENSMUST00000029803.4 ENSMUST00000029803.5 ENSMUST00000029803.6 ENSMUST00000029803.7 ENSMUST00000029803.8 ENSMUST00000029803.9 Eif4e NM_007917 Q3TK95 Q3TK95_MOUSE uc008rnn.1 uc008rnn.2 uc008rnn.3 uc008rnn.4 This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Nucleus, nuclear body Belongs to the eukaryotic initiation factor 4E family. G1/S transition of mitotic cell cycle RNA 7-methylguanosine cap binding P-body RNA binding translation initiation factor activity cytoplasm cytosol mRNA cap binding complex translation translational initiation regulation of translation cytoplasmic stress granule eukaryotic translation initiation factor 4F complex RISC complex enzyme binding lung development eukaryotic initiation factor 4G binding macromolecular complex cytoplasmic ribonucleoprotein granule positive regulation of mitotic cell cycle perinuclear region of cytoplasm repressing transcription factor binding postsynapse glutamatergic synapse postsynaptic cytosol uc008rnn.1 uc008rnn.2 uc008rnn.3 uc008rnn.4 
ENSMUST00000029804.13 Metap1 ENSMUST00000029804.13 methionyl aminopeptidase 1 (from RefSeq NM_175224.4) ENSMUST00000029804.1 ENSMUST00000029804.10 ENSMUST00000029804.11 ENSMUST00000029804.12 ENSMUST00000029804.2 ENSMUST00000029804.3 ENSMUST00000029804.4 ENSMUST00000029804.5 ENSMUST00000029804.6 ENSMUST00000029804.7 ENSMUST00000029804.8 ENSMUST00000029804.9 MAP11_MOUSE NM_175224 Q8BP48 uc008rnl.1 uc008rnl.2 uc008rnl.3 Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Reaction=Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; EC=3.4.11.18; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone. Associates with the 60S ribosomal subunit of the 80S translational complex. Cytoplasm The C6H2-type zinc finger recruits ZNG1, promoting zinc cofactor transfer in the peptidase domain of METAP1. Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. aminopeptidase activity cytoplasm proteolysis peptidase activity metalloexopeptidase activity hydrolase activity metal ion binding metalloaminopeptidase activity protein initiator methionine removal uc008rnl.1 uc008rnl.2 uc008rnl.3 
ENSMUST00000029805.13 Mttp ENSMUST00000029805.13 microsomal triglyceride transfer protein, transcript variant 2 (from RefSeq NM_008642.3) B2CXA7 ENSMUST00000029805.1 ENSMUST00000029805.10 ENSMUST00000029805.11 ENSMUST00000029805.12 ENSMUST00000029805.2 ENSMUST00000029805.3 ENSMUST00000029805.4 ENSMUST00000029805.5 ENSMUST00000029805.6 ENSMUST00000029805.7 ENSMUST00000029805.8 ENSMUST00000029805.9 MTP_MOUSE Mtp NM_008642 O08601 Q3UJA0 Q91X33 uc033iaa.1 uc033iaa.2 uc033iaa.3 Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:16478722, PubMed:18502767, PubMed:33168624). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:17635917, PubMed:10713055, PubMed:9502759, PubMed:18502767, PubMed:33168624). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (PubMed:18502767). [Isoform 2]: Critical for the development of natural killer T (NKT) cells (PubMed:17312007). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:17635917). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38572; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2- diacyl-sn-glycero-3-phosphoethanolamine(out); Xref=Rhea:RHEA:38895, ChEBI:CHEBI:64612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38896; Evidence=; Reaction=a cholesterol ester(in) = a cholesterol ester(out); Xref=Rhea:RHEA:39007, ChEBI:CHEBI:17002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39008; Evidence=; Reaction=a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out); Xref=Rhea:RHEA:39011, ChEBI:CHEBI:64615; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39012; Evidence=; Interacts with PRAP1. [Isoform 1]: Heterodimer; heterodimerizes with the protein disulfide isomerase (P4HB/PDI) (PubMed:17635917). Interacts with APOB (By similarity). [Isoform 2]: Heterodimer; heterodimerizes with the protein disulfide isomerase (P4HB/PDI) (PubMed:17635917). Endoplasmic reticulum [Isoform 1]: Endoplasmic reticulum Golgi apparatus Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum (By similarity). [Isoform 2]: Endoplasmic reticulum Golgi apparatus Event=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=MTP-A; IsoId=O08601-1; Sequence=Displayed; Name=2; Synonyms=MTPv1, MTP-B; IsoId=O08601-2; Sequence=VSP_038546; [Isoform 1]: Mainly expressed in the intestine and the liver, and at lower levels in white and brown fat cells (PubMed:17635917, PubMed:8660984). Expressed in heart (PubMed:9502759). [Isoform 2]: Ubiquitous, and is the major isoform in hematopoietic cells and adipocytes. Expression in the yolk sac tissues followed by expression in the primordial liver cell nests as early as day 9 post- coitum (9.5 dpc). Intestinal expression is detected around 12.5 dpc and attains full adult expression patterns by 14.5 dpc. Up-regulated by FOXO1. Expressed in a circadian manner in the liver. [Isoform 2]: Cleaved by signal peptidase between residues Gln-33 and Asn-34. Lowers plasma and tissue triglyceride levels, and increases cellular free cholesterol. lipid transporter activity protein binding phospholipid transporter activity endoplasmic reticulum rough endoplasmic reticulum Golgi apparatus protein lipidation lipid metabolic process triglyceride metabolic process lipid transport circadian rhythm steroid metabolic process cholesterol metabolic process lipid binding protein secretion phospholipid transport basolateral plasma membrane brush border membrane microvillus membrane vesicle apolipoprotein binding triglyceride transport plasma lipoprotein particle assembly lipoprotein metabolic process cholesterol homeostasis lipoprotein transport receptor complex protein heterodimerization activity response to calcium ion ceramide 1-phosphate transporter activity ceramide 1-phosphate transport uc033iaa.1 uc033iaa.2 uc033iaa.3 
ENSMUST00000029806.13 Dapp1 ENSMUST00000029806.13 dual adaptor for phosphotyrosine and 3-phosphoinositides 1, transcript variant 1 (from RefSeq NM_011932.3) Bam32 DAPP1_MOUSE ENSMUST00000029806.1 ENSMUST00000029806.10 ENSMUST00000029806.11 ENSMUST00000029806.12 ENSMUST00000029806.2 ENSMUST00000029806.3 ENSMUST00000029806.4 ENSMUST00000029806.5 ENSMUST00000029806.6 ENSMUST00000029806.7 ENSMUST00000029806.8 ENSMUST00000029806.9 NM_011932 Q9QXT1 Q9R178 uc008rmt.1 uc008rmt.2 uc008rmt.3 uc008rmt.4 May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. Interacts with PtdIns(3,4,5)P3 and PLCG2. Cytoplasm Membrane ; Peripheral membrane protein Note=Membrane-associated after cell stimulation leading to its translocation. Upon B-cell activation. Phosphorylated on tyrosine residues. phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm plasma membrane membrane phosphatidylinositol-3,4-bisphosphate binding uc008rmt.1 uc008rmt.2 uc008rmt.3 uc008rmt.4 
ENSMUST00000029812.14 Nfkb1 ENSMUST00000029812.14 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105, transcript variant 1 (from RefSeq NM_008689.3) B2RRQ6 ENSMUST00000029812.1 ENSMUST00000029812.10 ENSMUST00000029812.11 ENSMUST00000029812.12 ENSMUST00000029812.13 ENSMUST00000029812.2 ENSMUST00000029812.3 ENSMUST00000029812.4 ENSMUST00000029812.5 ENSMUST00000029812.6 ENSMUST00000029812.7 ENSMUST00000029812.8 ENSMUST00000029812.9 NFKB1_MOUSE NM_008689 P25799 Q3TZE8 Q3V2V6 Q6TDG8 Q75ZL1 Q80Y21 Q8C712 uc008rlx.1 uc008rlx.2 uc008rlx.3 NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I- kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. Plays a role in the regulation of apoptosis. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome- dependent degradation of NFKB1/p105. [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B. Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105. [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65- p50 complex to form a transcription factor. Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. [Isoform 3]: Isoform 3 (p98) (but not p84 or p105) acts as a transactivator of NF-kappa-B-regulated gene expression. [Isoform 5]: Act as inhibitors of transactivation of p50 NF- kappa-B subunit, probably by sequestering it in the cytoplasm. [Isoform 6]: Act as inhibitors of transactivation of p50 NF- kappa-B subunit, probably by sequestering it in the cytoplasm. [Isoform 7]: Act as inhibitors of transactivation of p50 NF- kappa-B subunit, probably by sequestering it in the cytoplasm. Component of the NF-kappa-B p65-p50 complex (By similarity). Homodimer; component of the NF-kappa-B p50-p50 complex (By similarity). Component of the NF-kappa-B p105-p50 complex (By similarity). Component of the NF-kappa-B p50-c-Rel complex (By similarity). Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3 (By similarity). Also interacts with MAP3K8 (By similarity). NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF- kappa-B dependent expression via its histone acetyltransferase activity (By similarity). Interacts with TSC22D3; this interaction prevents nuclear translocation and DNA-binding (By similarity). Interacts with SPAG9 and UNC5CL (By similarity). NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50 (By similarity). NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2 (By similarity). Interacts with GSK3B; the interaction prevents processing of p105 to p50 (By similarity). NFKB1/p50 interacts with NFKBIE (By similarity). NFKB1/p50 interacts with NFKBIZ (PubMed:11356851, PubMed:15241416). Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (PubMed:11931770). Directly interacts with MEN1 (By similarity). Interacts with HIF1AN (By similarity). Interacts with FEM1AA; interaction is direct (PubMed:18270204). P25799; Q9DBR0: Akap8; NbExp=4; IntAct=EBI-643958, EBI-4285802; P25799; O09106: Hdac1; NbExp=2; IntAct=EBI-643958, EBI-301912; P25799; Q04207: Rela; NbExp=6; IntAct=EBI-643958, EBI-644400; P25799; Q15788: NCOA1; Xeno; NbExp=2; IntAct=EBI-643958, EBI-455189; P25799-1; Q04207: Rela; NbExp=6; IntAct=EBI-643974, EBI-644400; PRO_0000030312; Q04207: Rela; NbExp=3; IntAct=EBI-1209193, EBI-644400; PRO_0000030313; Q3V096: Ankrd42; NbExp=3; IntAct=EBI-1209141, EBI-15861272; PRO_0000030313; Q04863: Relb; NbExp=2; IntAct=EBI-1209141, EBI-1209145; [Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm [Nuclear factor NF-kappa-B p50 subunit]: Nucleus Cytoplasm Note=Association with NFKBIA inhibitor (I-kappa-B), promotes its retention in the cytoplasm in an inactive form. Translocates into the nucleus following NFKBIA degradation. [Isoform 5]: Cytoplasm [Isoform 6]: Nucleus Cytoplasm [Isoform 7]: Nucleus Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=p105; IsoId=P25799-1; Sequence=Displayed; Name=2; Synonyms=p84; IsoId=P25799-2; Sequence=VSP_005583; Name=3; Synonyms=p98; IsoId=P25799-3; Sequence=VSP_005584; Name=4; IsoId=P25799-4; Sequence=VSP_017237, VSP_017238; Name=5; Synonyms=P70, I-kappa-B gamma; IsoId=P25799-5; Sequence=VSP_017236; Name=6; Synonyms=p63, I-kappa-B gamma-1; IsoId=P25799-6; Sequence=VSP_017236, VSP_005584; Name=7; Synonyms=p55, I-kappa-B gamma-2; IsoId=P25799-7; Sequence=VSP_017236, VSP_005583; By phorbol ester and TNF-alpha. The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and transcription activation. Glycine-rich region (GRR) is a critical element in the generation of p50 (Nuclear factor NF-kappa-B p50 subunit) by acting as a proteasomal 'stop signal', which leads to limited proteasomal degradation of the C-terminus, while generating p50. Generation of the NF-kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit) transcription factor takes place both cotranslationally and post-translationally via non-mutually exclusive mechanisms (By similarity). A cotranslational processing allows the production of both p50 and p105 (Nuclear factor NF-kappa-B p105 subunit) from a single NFKB1 mRNA (PubMed:9529257). While translation occurs, the particular unfolded structure after the GRR repeat region acts as a substrate for the proteasome, promoting degradation of the C-terminus (PubMed:9529257). The GRR acts as a proteasomal 'stop signal', protecting the region upstream of the GRR from degradation and promoting generation of p50 (PubMed:9529257). It is unclear if limited proteasome degradation during cotranslational processing depends on ubiquitination (PubMed:9529257). NF-kappa-B p50 is also generated post- translationally following ubiquitination by the KPC complex, leading to limited processing by the proteasome downstream of the GRR region, thereby generating p50 (By similarity). [Nuclear factor NF-kappa-B p105 subunit]: Phosphorylation at the C-terminus by IKBKB/IKKB acts as a signal for ubiquitination and promotes either complete degradation or processing to generate the NF- kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit) (By similarity). Phosphorylation at Ser-910 primes p105 for proteolytic processing in response to TNF-alpha stimulation (By similarity). Phosphorylation at Ser-926, Ser-930 and Ser-935 are required for BTRC/BTRCP-mediated ubiquitination and proteolysis (By similarity). Phosphorylation at Ser- 930 is also required for ubiquitination by the KPC complex and limited processing to generate NF-kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit) (By similarity). [Nuclear factor NF-kappa-B p105 subunit]: Polyubiquitinated at multiple Lys residues in the C-terminus (By similarity). Polyubiquitinated by the SCF(FBXW11) and SCF(BTRC) complexes following phosphorylation at Ser-926, Ser-930 and Ser-935, leading to its complete degradation (By similarity). In contrast, polyubiquitination by the KPC complex following phosphorylation at Ser-930 leads to limited proteosomal processing and generation of the active NF-kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit) (By similarity). S-nitrosylation of Cys-59 affects DNA binding. The covalent modification of cysteine by 15-deoxy-Delta12,14- prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation. Sequence=BAC35117.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding negative regulation of cytokine production DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm mitochondrion cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process inflammatory response response to oxidative stress signal transduction I-kappaB kinase/NF-kappaB signaling transcription factor binding positive regulation of gene expression negative regulation of gene expression negative regulation of calcidiol 1-monooxygenase activity response to organic cyclic compound enzyme binding heat shock protein binding macromolecular complex response to cytokine response to muscle stretch NIK/NF-kappaB signaling identical protein binding protein homodimerization activity actinin binding neuron projection negative regulation of apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of interleukin-12 biosynthetic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity lymph node development negative regulation of inflammatory response cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to nicotine cellular response to carbohydrate stimulus cellular response to cytokine stimulus cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to dsRNA cellular response to organic cyclic compound positive regulation of canonical Wnt signaling pathway positive regulation of hyaluronan biosynthetic process cellular response to peptide positive regulation of pri-miRNA transcription from RNA polymerase II promoter cellular response to angiotensin cellular response to diterpene cellular response to glucoside cellular response to brain-derived neurotrophic factor stimulus positive regulation of miRNA metabolic process positive regulation of gene silencing by miRNA uc008rlx.1 uc008rlx.2 uc008rlx.3 
ENSMUST00000029814.10 Manba ENSMUST00000029814.10 mannosidase, beta A, lysosomal (from RefSeq NM_027288.3) A0A0R4J092 A0A0R4J092_MOUSE ENSMUST00000029814.1 ENSMUST00000029814.2 ENSMUST00000029814.3 ENSMUST00000029814.4 ENSMUST00000029814.5 ENSMUST00000029814.6 ENSMUST00000029814.7 ENSMUST00000029814.8 ENSMUST00000029814.9 Manba NM_027288 uc008rlv.1 uc008rlv.2 uc008rlv.3 uc008rlv.4 Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides. Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.; EC=3.2.1.25; Evidence=; Glycan metabolism; N-glycan degradation. Monomer. Lysosome Belongs to the glycosyl hydrolase 2 family. hydrolase activity, hydrolyzing O-glycosyl compounds beta-mannosidase activity mannose binding lysosome carbohydrate metabolic process intracellular membrane-bounded organelle uc008rlv.1 uc008rlv.2 uc008rlv.3 uc008rlv.4 
ENSMUST00000029815.8 Cisd2 ENSMUST00000029815.8 CDGSH iron sulfur domain 2 (from RefSeq NM_025902.3) CISD2_MOUSE Cdgsh2 ENSMUST00000029815.1 ENSMUST00000029815.2 ENSMUST00000029815.3 ENSMUST00000029815.4 ENSMUST00000029815.5 ENSMUST00000029815.6 ENSMUST00000029815.7 NM_025902 Noxp70 Q9CQB5 Q9D0Y0 Zcd2 uc008rlk.1 uc008rlk.2 uc008rlk.3 uc008rlk.4 Regulator of autophagy that contributes to antagonize BECN1- mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity). Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 1 [2Fe-2S] cluster. ; Redox potential: E is 0 +/- 10 mV for 2Fe-2S at pH 7.5.; Homodimer. Interacts with BCL2; the interaction is direct and disrupted by BIK interaction with BCL2. Interacts with BCL2L1. Interacts with ITPR1 (By similarity). Endoplasmic reticulum membrane ; Single-pass membrane protein Mitochondrion outer membrane ; Single-pass membrane protein Note=According to PubMed:19451219, it mainly localizes to the mitochondrion outer membrane and localizes only at low level to the endoplasmic reticulum. However, inverse results are observed in human cells. Brain. Expression decreases in an age-dependent manner. Premature aging associated with a shortened life span, probably caused by mitochondrial degeneration and autophagy. 8 week old mice begin to acquire a set of aged appearance phenomena remarkably similar to those of premature aging syndrome, including prominent eyes and protruding ears. Ocular abnormalities are observed: mice develop opaque eyes and blindness, which is accompanied by cornea damage at 20 week old. The opacity of the cornea is due to debris deposition in the scar tissue outside the cornea. In addition, corneal neovascularization is observed, possibly impairing vision. An early depigmentation in the fur at around 48 week old is also observed; furthermore, hair follicle atrophy and a decreased hair density is detected. A decrease in the hair regrowth rate is also observed. Additionally, the skin of 48-week-old mice exhibits a phenotype with a noticeably thickened dermis, an expanded surface, and a significant decrease in subcutaneous adipose tissue and muscle. The trabeculae of the femur are noticeably thinner and dual energy X-ray absorptiometer (DEXA) detects a decrease in femur density after 8 week old. Mice also display a significant lordokyphosis phenotype after 12 week old; leading to a decrease in mean thoracic volume and thence pulmonary function abnormalities. Muscle degeneration is detectable at 3 week old with a progressive degeneration of muscle fibers and the magnitude of the degeneration exacerbated with age. Belongs to the CISD protein family. CISD2 subfamily. mitophagy mitochondrion mitochondrial outer membrane endoplasmic reticulum endoplasmic reticulum membrane autophagy multicellular organism aging regulation of autophagy membrane integral component of membrane macromolecular complex protein homodimerization activity intracellular membrane-bounded organelle metal ion binding perinuclear region of cytoplasm iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding perinuclear endoplasmic reticulum uc008rlk.1 uc008rlk.2 uc008rlk.3 uc008rlk.4 
ENSMUST00000029817.11 Bdh2 ENSMUST00000029817.11 3-hydroxybutyrate dehydrogenase, type 2, transcript variant 2 (from RefSeq NM_027208.2) Bdh2 DHRS6_MOUSE Dhrs6 ENSMUST00000029817.1 ENSMUST00000029817.10 ENSMUST00000029817.2 ENSMUST00000029817.3 ENSMUST00000029817.4 ENSMUST00000029817.5 ENSMUST00000029817.6 ENSMUST00000029817.7 ENSMUST00000029817.8 ENSMUST00000029817.9 NM_027208 Q8JZV9 uc008rla.1 uc008rla.2 uc008rla.3 uc008rla.4 uc008rla.5 NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines (By similarity). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (PubMed:20550936, PubMed:24863067, PubMed:24777603). May act as a 3- hydroxybutyrate dehydrogenase (By similarity). (Microbial infection) May play a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria. Host iron-siderophore complexes can be used by bacteria to promote their own growth and pathogenicity. Reaction=cis-4-hydroxy-L-proline + NAD(+) = 4-oxo-L-proline + H(+) + NADH; Xref=Rhea:RHEA:13601, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:63727, ChEBI:CHEBI:84813; EC=1.1.1.104; Evidence= PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:13603; Evidence= Reaction=(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH; Xref=Rhea:RHEA:20521, ChEBI:CHEBI:10983, ChEBI:CHEBI:13705, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.30; Evidence=; Amino-acid metabolism. Siderophore biosynthesis. Homotetramer. Cytoplasm Detected in liver, spleen and macrophages (PubMed:24863067). Widely expressed. Down-regulated upon E.coli infection to limit access to host iron pool. Down-regulated in macrophages by exposure to bacterial lipopolysaccharide (LPS). Mutant mice are born at the expected Mendelian frequency. They display microcytic and hypochromic anemia and iron overload in spleen and liver associated with heme toxicity when kept on high-iron diet. The plasma levels of ketone bodies is normal. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Postulated to act as a 3-hydroxybutyrate dehydrogenase, however its contribution to ketone body formation appears to be physiologically irrelevant since it has very low affinity for the substrate. 3-hydroxybutyrate dehydrogenase activity cytoplasm cytosol fatty acid beta-oxidation oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor siderophore biosynthetic process epithelial cell differentiation heme metabolic process NAD binding iron ion homeostasis oxidation-reduction process uc008rla.1 uc008rla.2 uc008rla.3 uc008rla.4 uc008rla.5 
ENSMUST00000029822.6 Tacr3 ENSMUST00000029822.6 tachykinin receptor 3 (from RefSeq NM_021382.6) ENSMUST00000029822.1 ENSMUST00000029822.2 ENSMUST00000029822.3 ENSMUST00000029822.4 ENSMUST00000029822.5 NK3R_MOUSE NM_021382 P47937 Q61968 Q8BL44 Q9JKN0 Tac3r uc008rky.1 uc008rky.2 uc008rky.3 uc008rky.4 This gene belongs to a family of genes that function as receptors for tachykinins. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Mar 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK031898.1, BC066845.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849389 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. Cell membrane; Multi-pass membrane protein. The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity tachykinin receptor activity nucleus cytoplasm plasma membrane signal transduction G-protein coupled receptor signaling pathway tachykinin receptor signaling pathway aging positive regulation of heart rate membrane integral component of membrane response to estradiol dendrite membrane neuronal cell body membrane regulation of dopamine metabolic process response to cocaine hyperosmotic salinity response response to morphine positive regulation of blood pressure regulation of feeding behavior positive regulation of uterine smooth muscle contraction sperm midpiece positive regulation of flagellated sperm motility uc008rky.1 uc008rky.2 uc008rky.3 uc008rky.4 
ENSMUST00000029837.14 Uox ENSMUST00000029837.14 urate oxidase (from RefSeq NM_009474.5) ENSMUST00000029837.1 ENSMUST00000029837.10 ENSMUST00000029837.11 ENSMUST00000029837.12 ENSMUST00000029837.13 ENSMUST00000029837.2 ENSMUST00000029837.3 ENSMUST00000029837.4 ENSMUST00000029837.5 ENSMUST00000029837.6 ENSMUST00000029837.7 ENSMUST00000029837.8 ENSMUST00000029837.9 NM_009474 Q543J0 Q543J0_MOUSE Uox uc008rrp.1 uc008rrp.2 uc008rrp.3 Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Reaction=H2O + O2 + urate = 5-hydroxyisourate + H2O2; Xref=Rhea:RHEA:21368, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17775, ChEBI:CHEBI:18072; EC=1.7.3.3; Evidence= Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3. Peroxisome Belongs to the uricase family. urate oxidase activity peroxisome purine nucleobase metabolic process oxidoreductase activity urate catabolic process oxidation-reduction process uc008rrp.1 uc008rrp.2 uc008rrp.3 
ENSMUST00000029838.11 Rpf1 ENSMUST00000029838.11 ribosome production factor 1 homolog, transcript variant 2 (from RefSeq NM_027371.3) Bxdc5 ENSMUST00000029838.1 ENSMUST00000029838.10 ENSMUST00000029838.2 ENSMUST00000029838.3 ENSMUST00000029838.4 ENSMUST00000029838.5 ENSMUST00000029838.6 ENSMUST00000029838.7 ENSMUST00000029838.8 ENSMUST00000029838.9 NM_027371 Q3TBS4 Q5EBN9 Q7TND5 Q8K343 RPF1_MOUSE uc008rrl.1 uc008rrl.2 uc008rrl.3 uc008rrl.4 uc008rrl.5 May be required for ribosome biogenesis. Nucleus, nucleolus Sequence=AAH28802.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=AAH56165.2; Type=Erroneous initiation; Evidence=; Sequence=AAH89369.2; Type=Erroneous initiation; Evidence=; RNA binding nucleus nucleolus rRNA processing rRNA binding preribosome, large subunit precursor ribosome biogenesis uc008rrl.1 uc008rrl.2 uc008rrl.3 uc008rrl.4 uc008rrl.5 
ENSMUST00000029839.11 Spata1 ENSMUST00000029839.11 spermatogenesis associated 1, transcript variant 1 (from RefSeq NM_027617.3) B9EI96 ENSMUST00000029839.1 ENSMUST00000029839.10 ENSMUST00000029839.2 ENSMUST00000029839.3 ENSMUST00000029839.4 ENSMUST00000029839.5 ENSMUST00000029839.6 ENSMUST00000029839.7 ENSMUST00000029839.8 ENSMUST00000029839.9 NM_027617 Q7TPN4 Q9D5R4 SPAT1_MOUSE uc008rri.1 uc008rri.2 Interacts with IFT20. Cytoplasmic vesicle, secretory vesicle, acrosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D5R4-1; Sequence=Displayed; Name=2; IsoId=Q9D5R4-2; Sequence=VSP_035225, VSP_035226; Highly abundant in the testis, and is also expressed in the heart and kidney (at protein level). Detectable at postnatal day 24 (P24) and its expression is increased at day P30 and P35. molecular_function cellular_component biological_process uc008rri.1 uc008rri.2 
ENSMUST00000029842.9 Bcl10 ENSMUST00000029842.9 B cell leukemia/lymphoma 10 (from RefSeq NM_009740.2) BCL10_MOUSE Ciper Clap ENSMUST00000029842.1 ENSMUST00000029842.2 ENSMUST00000029842.3 ENSMUST00000029842.4 ENSMUST00000029842.5 ENSMUST00000029842.6 ENSMUST00000029842.7 ENSMUST00000029842.8 NM_009740 Q3UBN4 Q9Z0H7 uc008rqs.1 uc008rqs.2 uc008rqs.3 uc008rqs.4 uc008rqs.5 Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:22265677). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:22265677). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (By similarity). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:22265677). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (By similarity). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK (By similarity). Homomultimer; homooligomerized following recruitment by CARD domain-containing proteins that form a nucleating helical template that recruits BCL10 via CARD-CARD interaction (By similarity). Self- associates by CARD-CARD interaction and interacts with other CARD- proteins such as CARD9, CARD10, CARD11 and CARD14 (PubMed:22265677, PubMed:22880103). Forms a complex with CARD14 and MALT1; resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex (By similarity). Forms a complex with CARD11 and MALT1; resulting in the formation of a CBM (CARD11-BCL10-MALT1) complex (By similarity). Forms a complex with CARD9 and MALT1; resulting in the formation of a CBM (CARD9-BCL10- MALT1) complex (PubMed:22265677). Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (By similarity). Binds caspase-9 with its C-terminal domain (By similarity). Interacts with TRAF2 and BIRC2/c-IAP2 (By similarity). Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (PubMed:15213237). Q9Z0H7; Q66677: E10; Xeno; NbExp=3; IntAct=EBI-8545413, EBI-11709474; Cytoplasm Membrane raft Note=Colocalized with DPP4 in membrane rafts. Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Detected in developing brain, olfactory epithelium, tongue, whisker follicles, salivary gland, heart, lung, liver and intestinal epithelia of stage 15 embryos. Phosphorylated by IKBKB/IKKB. Ubiquitinated via both 'Lys-63'-linked and linear ('Met-1'-linked) polyubiquitin chains in response to T-cell receptor (TCR) activation. Ubiquitination is recognized by IKBKG/NEMO, the regulatory subunit of I-kappa-B kinase (IKK), and is required for TCR-induced NF-kappa-B activation. Linear ubiquitination at Lys-17, Lys-31 and Lys-63 is mediated by RNF31/HOIP; linear ubiquitination is recognized with much higher affinity than 'Lys-63'-linked ubiquitin by IKBKG/NEMO. CARD11 is required for linear ubiquitination by HOIP by promoting the targeting of BCL10 to RNF31/HOIP. Proteolytically cleaved by MALT1; required for T-cell activation. immunological synapse B cell apoptotic process neural tube closure protease binding toll-like receptor signaling pathway response to molecule of bacterial origin adaptive immune response immune system process negative regulation of mature B cell apoptotic process transcription coactivator activity protein binding nucleus cytoplasm lysosome cytosol cytoplasmic microtubule apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cellular defense response I-kappaB kinase/NF-kappaB signaling protein C-terminus binding transcription factor binding cell death cysteine-type endopeptidase activator activity involved in apoptotic process response to fungus membrane immunoglobulin mediated immune response kinase activator activity enzyme binding kinase binding protein kinase binding positive regulation of protein ubiquitination ubiquitin protein ligase binding lipopolysaccharide-mediated signaling pathway response to food CBM complex macromolecular complex positive regulation of kinase activity positive regulation of phosphorylation identical protein binding protein homodimerization activity regulation of apoptotic process positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase B binding protein self-association innate immune response membrane raft positive regulation of interleukin-8 biosynthetic process mast cell activation positive regulation of transcription, DNA-templated protein heterodimerization activity perinuclear region of cytoplasm CARD domain binding T cell receptor signaling pathway regulation of T cell receptor signaling pathway positive regulation of T cell activation NF-kappaB binding positive regulation of NF-kappaB transcription factor activity protein oligomerization protein homooligomerization protein heterooligomerization T cell apoptotic process cellular response to mechanical stimulus positive regulation of execution phase of apoptosis positive regulation of extrinsic apoptotic signaling pathway activation of JUN kinase activity fibroblast apoptotic process thymocyte apoptotic process uc008rqs.1 uc008rqs.2 uc008rqs.3 uc008rqs.4 uc008rqs.5 
ENSMUST00000029845.15 Ddah1 ENSMUST00000029845.15 dimethylarginine dimethylaminohydrolase 1 (from RefSeq NM_026993.3) DDAH1_MOUSE ENSMUST00000029845.1 ENSMUST00000029845.10 ENSMUST00000029845.11 ENSMUST00000029845.12 ENSMUST00000029845.13 ENSMUST00000029845.14 ENSMUST00000029845.2 ENSMUST00000029845.3 ENSMUST00000029845.4 ENSMUST00000029845.5 ENSMUST00000029845.6 ENSMUST00000029845.7 ENSMUST00000029845.8 ENSMUST00000029845.9 NM_026993 Q3UF65 Q9CWS0 uc008rqr.1 uc008rqr.2 uc008rqr.3 uc008rqr.4 Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. Reaction=H2O + N(omega),N(omega)-dimethyl-L-arginine = dimethylamine + L-citrulline; Xref=Rhea:RHEA:17305, ChEBI:CHEBI:15377, ChEBI:CHEBI:57743, ChEBI:CHEBI:58040, ChEBI:CHEBI:58326; EC=3.5.3.18; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17306; Evidence= Reaction=H2O + N(omega)-methyl-L-arginine = L-citrulline + methylamine; Xref=Rhea:RHEA:25173, ChEBI:CHEBI:15377, ChEBI:CHEBI:57743, ChEBI:CHEBI:59338, ChEBI:CHEBI:114953; EC=3.5.3.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25174; Evidence=; Inhibited by zinc ions. Monomer. Detected in skeletal muscle, lung, heart, liver, kidney and brain (at protein level). Mutants from some strains grow and develop normally (PubMed:21493890, PubMed:37296100). Mutant tissues do not show any dimethylarginine dimethylaminohydrolase activity. They have higher than normal tissue levels and plasma levels of asymmetric dimethylarginine (ADMA) and N(G)-monomethyl-L-arginine (MMA). They also have decreased nitric oxide porduction and increased blood pressure. They do not show differences in the structure of the kidney, lung or heart (PubMed:37296100, PubMed:21493890). Death at embryonic stages have been shown in other strains. Heterozygous mice show no visible phenotype, but have higher than normal tissue and plasma levels of asymmetric dimethylarginine (ADMA). They have increased mean arterial blood pressure and systemic vascular resistance, and decreased cardiac output and heart rate, probably due to reduced levels of nitric oxide (NO) (PubMed:17273169). Belongs to the DDAH family. citrulline metabolic process regulation of systemic arterial blood pressure mitochondrion arginine metabolic process arginine catabolic process nitric oxide biosynthetic process zinc ion binding negative regulation of cell proliferation dimethylargininase activity amino acid binding hydrolase activity protein nitrosylation negative regulation of vascular permeability positive regulation of nitric oxide biosynthetic process positive regulation of angiogenesis metal ion binding negative regulation of cellular response to hypoxia uc008rqr.1 uc008rqr.2 uc008rqr.3 uc008rqr.4 
ENSMUST00000029846.5 Ccn1 ENSMUST00000029846.5 cellular communication network factor 1 (from RefSeq NM_010516.2) Ccn1 Cyr61 ENSMUST00000029846.1 ENSMUST00000029846.2 ENSMUST00000029846.3 ENSMUST00000029846.4 NM_010516 Q3TX21 Q3TX21_MOUSE uc008rqq.1 uc008rqq.2 uc008rqq.3 uc008rqq.4 Secreted Belongs to the CCN family. Lacks conserved residue(s) required for the propagation of feature annotation. positive regulation of protein phosphorylation insulin-like growth factor binding extracellular region positive regulation of cell migration positive regulation of bone mineralization positive regulation of BMP signaling pathway positive regulation of osteoblast proliferation wound healing, spreading of cells positive regulation of osteoblast differentiation positive regulation of protein kinase activity positive regulation of transcription from RNA polymerase II promoter regulation of ERK1 and ERK2 cascade uc008rqq.1 uc008rqq.2 uc008rqq.3 uc008rqq.4 
ENSMUST00000029848.5 Col24a1 ENSMUST00000029848.5 collagen, type XXIV, alpha 1, transcript variant 1 (from RefSeq NM_027770.3) B2RT51 COOA1_MOUSE E9QNS5 ENSMUST00000029848.1 ENSMUST00000029848.2 ENSMUST00000029848.3 ENSMUST00000029848.4 NM_027770 Q30D77 uc008rqm.1 uc008rqm.2 uc008rqm.3 This gene encodes the alpha-1 subunit of type XXIV collagen, one of the low abundance fibril-forming collagens found in cartilage. The encoded protein has structural features of invertebrate fibrillar collagens and is expressed predominantly in bone tissue. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]. Involved in osteoblast differentiation. Secreted, extracellular space, extracellular matrix. Expressed in skeleton. Found at ossification centers of the craniofacial, axial and appendicular skeleton. Also expressed in retina and to a lower extent in cornea, skin and tendon. Expression is confined to the developing eye and skeleton. First level of expression are detectable around 15 dpc. Belongs to the fibrillar collagen family. skeletal system development hematopoietic progenitor cell differentiation extracellular matrix structural constituent extracellular region collagen trimer extracellular space extracellular matrix structural constituent conferring tensile strength extracellular matrix organization collagen fibril organization notochord development extracellular matrix uc008rqm.1 uc008rqm.2 uc008rqm.3 
ENSMUST00000029850.15 Cryz ENSMUST00000029850.15 crystallin, zeta, transcript variant 8 (from RefSeq NR_151774.1) ENSMUST00000029850.1 ENSMUST00000029850.10 ENSMUST00000029850.11 ENSMUST00000029850.12 ENSMUST00000029850.13 ENSMUST00000029850.14 ENSMUST00000029850.2 ENSMUST00000029850.3 ENSMUST00000029850.4 ENSMUST00000029850.5 ENSMUST00000029850.6 ENSMUST00000029850.7 ENSMUST00000029850.8 ENSMUST00000029850.9 NR_151774 P47199 Q62508 Q99L63 QOR_MOUSE uc008rup.1 uc008rup.2 uc008rup.3 uc008rup.4 Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity). Reaction=2 a quinone + H(+) + NADPH = 2 a 1,4-benzosemiquinone + NADP(+); Xref=Rhea:RHEA:14269, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132124, ChEBI:CHEBI:134225; EC=1.6.5.5; Homotetramer. Cytoplasm Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. RNA binding mRNA 3'-UTR binding NADPH:quinone reductase activity cytoplasm cytosol zinc ion binding oxidoreductase activity xenobiotic catabolic process NADP binding protein homotetramerization oxidation-reduction process NADPH binding NADH binding uc008rup.1 uc008rup.2 uc008rup.3 uc008rup.4 
ENSMUST00000029865.4 Trp53inp1 ENSMUST00000029865.4 transformation related protein 53 inducible nuclear protein 1, transcript variant 1 (from RefSeq NM_021897.4) ENSMUST00000029865.1 ENSMUST00000029865.2 ENSMUST00000029865.3 NM_021897 Q923I6 Q9QXE4 Sip T53I1_MOUSE uc008rza.1 uc008rza.2 uc008rza.3 Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. Interacts with p53/TP53 and HIPK2. Interacts with PRKCG, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C. Cytoplasm, cytosol Nucleus Nucleus, PML body Cytoplasmic vesicle, autophagosome Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. [Isoform 2]: Cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SIP27, TEAP; IsoId=Q9QXE4-1; Sequence=Displayed; Name=2; Synonyms=SIP18; IsoId=Q9QXE4-2; Sequence=VSP_013177; Ubiquitously expressed with highest levels in the thymus. By adriamycin, methymethane sulfonate, ethanol, H(2)O(2), ultraviolet irradiation and heat shock. Rapidly induced in acinar cells of the pancreas with acute pancreatitis upon caerulein treatment. The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C. autophagosome assembly nucleus cytoplasm autophagosome cytosol regulation of transcription, DNA-templated autophagy apoptotic process cell cycle arrest negative regulation of cell proliferation response to heat regulation of autophagy positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression antioxidant activity PML body negative regulation of cell migration cytoplasmic vesicle cellular response to UV positive regulation of apoptotic process positive regulation of transcription, DNA-templated autophagic cell death negative regulation of fibroblast proliferation cellular response to ethanol cellular response to hydroperoxide cellular response to methyl methanesulfonate cellular oxidant detoxification negative regulation of myofibroblast differentiation positive regulation of apoptotic signaling pathway nucleolus uc008rza.1 uc008rza.2 uc008rza.3 
ENSMUST00000029871.12 Cdh17 ENSMUST00000029871.12 cadherin 17 (from RefSeq NM_019753.4) CAD17_MOUSE ENSMUST00000029871.1 ENSMUST00000029871.10 ENSMUST00000029871.11 ENSMUST00000029871.2 ENSMUST00000029871.3 ENSMUST00000029871.4 ENSMUST00000029871.5 ENSMUST00000029871.6 ENSMUST00000029871.7 ENSMUST00000029871.8 ENSMUST00000029871.9 NM_019753 Q9R100 uc008rzy.1 uc008rzy.2 uc008rzy.3 uc008rzy.4 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Cell membrane ; Single-pass type I membrane protein Highest expression is found in intestine with lower expression in spleen, bone marrow, lung and testis. No expression detected in liver, kidney, heart, brain or skeletal muscle. Expressed in precursor B-cells and myeloid cells. Expression increases in pro- and pre-B-I cells, decreases in large and small pre-B-II cells, and increases again in immature and mature B-cells. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. cell morphogenesis germinal center B cell differentiation marginal zone B cell differentiation integrin binding proton-dependent oligopeptide secondary active transmembrane transporter activity calcium ion binding protein binding nucleus plasma membrane integral component of plasma membrane cell-cell adherens junction oligopeptide transport cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules integrin-mediated signaling pathway cytoskeletal protein binding cell surface membrane integral component of membrane basolateral plasma membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex cell junction B cell differentiation positive regulation of integrin activation by cell surface receptor linked signal transduction adherens junction organization oligopeptide transmembrane transport protein homodimerization activity cell-cell adhesion mediated by cadherin cadherin binding metal ion binding spleen development cell-cell adhesion T cell mediated immunity uc008rzy.1 uc008rzy.2 uc008rzy.3 uc008rzy.4 
ENSMUST00000029875.4 Pip4p2 ENSMUST00000029875.4 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2, transcript variant 5 (from RefSeq NR_185050.1) ENSMUST00000029875.1 ENSMUST00000029875.2 ENSMUST00000029875.3 NR_185050 PP4P2_MOUSE Q9CZX7 Tmem55a uc008sbg.1 uc008sbg.2 uc008sbg.3 Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (PubMed:29378918). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:25674, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57795, ChEBI:CHEBI:58456; EC=3.1.3.78; Evidence=; Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein lysosome lysosomal membrane endosome plasma membrane membrane integral component of membrane hydrolase activity phagocytic vesicle membrane cytoplasmic vesicle late endosome membrane phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity phosphatidylinositol dephosphorylation negative regulation of phagocytosis uc008sbg.1 uc008sbg.2 uc008sbg.3 
ENSMUST00000029876.2 Calb1 ENSMUST00000029876.2 calbindin 1 (from RefSeq NM_009788.4) CALB1_MOUSE ENSMUST00000029876.1 NM_009788 P12658 Q545N6 uc008sbl.1 uc008sbl.2 uc008sbl.3 Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Interacts with RANBP9. Expressed in the modiolar nerve root and in bushy neurons in the ventral cochlear nucleus (at protein level). This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium. Belongs to the calbindin family. vitamin D binding calcium ion binding nucleus cytoplasm cytosol learning or memory short-term memory long-term memory locomotory behavior zinc ion binding retina layer formation axon dendrite stereocilium cuticular plate metanephric part of ureteric bud development neuron projection neuronal cell body dendritic spine cell body calyx of Held synapse metal ion binding regulation of synaptic plasticity calcium ion homeostasis retina development in camera-type eye cellular response to organic substance metanephric collecting duct development metanephric distal convoluted tubule development metanephric connecting tubule development cochlea development postsynapse glutamatergic synapse GABA-ergic synapse regulation of presynaptic cytosolic calcium ion concentration presynaptic cytosol postsynaptic cytosol calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration regulation of postsynaptic cytosolic calcium ion concentration calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration regulation of long-term synaptic potentiation uc008sbl.1 uc008sbl.2 uc008sbl.3 
ENSMUST00000029877.9 Decr1 ENSMUST00000029877.9 2,4-dienoyl CoA reductase 1, mitochondrial (from RefSeq NM_026172.4) DECR_MOUSE ENSMUST00000029877.1 ENSMUST00000029877.2 ENSMUST00000029877.3 ENSMUST00000029877.4 ENSMUST00000029877.5 ENSMUST00000029877.6 ENSMUST00000029877.7 ENSMUST00000029877.8 NM_026172 Q9CQ62 Q9DCI7 uc008sbm.1 uc008sbm.2 Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Reaction=a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)- enoyl-CoA + NADP(+); Xref=Rhea:RHEA:45912, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:85101, ChEBI:CHEBI:85493; EC=1.3.1.124; Evidence=; Reaction=a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)- enoyl-CoA + NADP(+); Xref=Rhea:RHEA:61892, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:85099, ChEBI:CHEBI:85493; EC=1.3.1.124; Evidence=; Reaction=(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (3E)-hexenoyl-CoA + NADP(+); Xref=Rhea:RHEA:44912, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:84788, ChEBI:CHEBI:84790; Evidence=; Homotetramer. Mitochondrion Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily. nucleoplasm mitochondrion cytosol lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation 2,4-dienoyl-CoA reductase (NADPH) activity oxidoreductase activity protein homotetramerization oxidation-reduction process NADPH binding uc008sbm.1 uc008sbm.2 
ENSMUST00000029879.15 Nbn ENSMUST00000029879.15 nibrin (from RefSeq NM_013752.3) ENSMUST00000029879.1 ENSMUST00000029879.10 ENSMUST00000029879.11 ENSMUST00000029879.12 ENSMUST00000029879.13 ENSMUST00000029879.14 ENSMUST00000029879.2 ENSMUST00000029879.3 ENSMUST00000029879.4 ENSMUST00000029879.5 ENSMUST00000029879.6 ENSMUST00000029879.7 ENSMUST00000029879.8 ENSMUST00000029879.9 NBN_MOUSE NM_013752 Nbs1 O88981 Q3UY57 Q811I6 Q8CCY0 Q9R1X1 Q9R207 uc008sbn.1 uc008sbn.2 uc008sbn.3 Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (By similarity). Component of the MRN complex composed of two heterodimers RAD50/MRE11 associated with a single NBN (By similarity). As part of the MRN complex, interacts with MCM9; the interaction recruits the complex to DNA repair sites (By similarity). Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11 and NBN (By similarity). Interacts with histone H2AX this requires phosphorylation of H2AX on 'Ser-139' (By similarity). Interacts with HJURP, INTS3, KPNA2 and TERF2 (By similarity). Interacts with RBBP8; the interaction links the role of the MRN complex in DNA double-strand break sensing to resection (By similarity). Interacts with SP100; recruits NBN to PML bodies (PubMed:12470659). Interacts with ATF2 (By similarity). Interacts with MTOR, MAPKAP1 isoform 2 and RICTOR; indicative for an association with the mTORC2 complex (By similarity). Interacts with MRNIP (By similarity). Interacts with UFL1; promoting UFL1 recruitment to double-strand breaks following DNA damage (By similarity). Interacts with CYREN (via XLF motif) (PubMed:30017584). Q9R207; Q61216: Mre11; NbExp=2; IntAct=EBI-2014862, EBI-2014813; Nucleus Nucleus, PML body Chromosome, telomere Chromosome Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. Acetylation of 'Lys-5' of histone H2AX (H2AXK5ac) promotes NBN/NBS1 assembly at the sites of DNA damage. High expression in the liver, heart and testis. Low expression in all other tissues analyzed. In the cerebellum the postmitotic Purkinje cells are marked specifically. A low level of expression is observed in all tissues. Highly specific expression was observed in organs with physiologic DNA double strand breakage (DSB), such as testis, thymus and spleen. Enhanced expression is also found at sites of high proliferative activity. These are the subventricular layer of the telencephalon and the diencephalon, the liver, lung, kidney and gut, as well as striated and smooth muscle cells in various organs. The FHA and BRCT domains are likely to have a crucial role for both binding to histone H2AX and for relocalization of MRE11/RAD50 complex to the vicinity of DNA damage. The C-terminal domain contains a MRE11-binding site, and this interaction is required for the nuclear localization of the MRN complex. The EEXXXDDL motif at the C-terminus is required for the interaction with ATM and its recruitment to sites of DNA damage and promote the phosphorylation of ATM substrates, leading to the events of DNA damage response. Phosphorylated by ATM in response of ionizing radiation, and such phosphorylation is responsible intra-S phase checkpoint control and telomere maintenance. DNA damage checkpoint telomere maintenance double-strand break repair via homologous recombination chromosome, telomeric region nuclear chromosome, telomeric region in utero embryonic development blastocyst growth DNA helicase activity damaged DNA binding protein binding nucleus replication fork chromosome nucleolus DNA repair double-strand break repair cellular response to DNA damage stimulus cell cycle mitotic cell cycle checkpoint mitotic G2 DNA damage checkpoint transcription factor binding cell proliferation positive regulation of cell proliferation telomere capping PML body Mre11 complex telomeric 3' overhang formation positive regulation of protein autophosphorylation positive regulation of telomere maintenance DNA duplex unwinding positive regulation of kinase activity site of double-strand break nuclear inclusion body signal transduction in response to DNA damage isotype switching negative regulation of neuron differentiation negative regulation of viral entry into host cell protein N-terminus binding regulation of fibroblast proliferation neuromuscular process controlling balance meiotic cell cycle t-circle formation intrinsic apoptotic signaling pathway negative regulation of telomere capping uc008sbn.1 uc008sbn.2 uc008sbn.3 
ENSMUST00000029881.10 Mmp16 ENSMUST00000029881.10 matrix metallopeptidase 16, transcript variant 1 (from RefSeq NM_019724.5) ENSMUST00000029881.1 ENSMUST00000029881.2 ENSMUST00000029881.3 ENSMUST00000029881.4 ENSMUST00000029881.5 ENSMUST00000029881.6 ENSMUST00000029881.7 ENSMUST00000029881.8 ENSMUST00000029881.9 MMP16_MOUSE NM_019724 Q6PEQ6 Q9ERT6 Q9WTR0 uc008sbw.1 uc008sbw.2 uc008sbw.3 uc008sbw.4 uc008sbw.5 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit retarded growth of the skeleton, especially in the cranium and long bones. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]. Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 zinc ions per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Cell membrane ; Single-pass type I membrane protein ; Extracellular side Note=Localized at the cell surface of melanoma cells. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Belongs to the peptidase M10A family. skeletal system development ossification endochondral ossification metalloendopeptidase activity extracellular space plasma membrane integral component of plasma membrane proteolysis peptidase activity metallopeptidase activity zinc ion binding membrane integral component of membrane protein processing hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix chondrocyte proliferation metal ion binding embryonic cranial skeleton morphogenesis bone development metalloaminopeptidase activity craniofacial suture morphogenesis uc008sbw.1 uc008sbw.2 uc008sbw.3 uc008sbw.4 uc008sbw.5 
ENSMUST00000029885.5 Cpne3 ENSMUST00000029885.5 copine III, transcript variant 1 (from RefSeq NM_027769.3) CPNE3_MOUSE Cpne3 ENSMUST00000029885.1 ENSMUST00000029885.2 ENSMUST00000029885.3 ENSMUST00000029885.4 Kiaa0636 NM_027769 Q5CZX9 Q5DU22 Q8BT60 uc008sby.1 uc008sby.2 uc008sby.3 Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AK220348.1, BC036983.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Monomer. Interacts with ERBB2 (preferentially with the tyrosine phosphorylated form); this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner. Interacts with SHC1; this interaction may mediate the binding of CPNE3 with ERBB2. Interacts with RACK1. Nucleus Cytoplasm Cell membrane Cell junction Cell junction, focal adhesion Note=Associates to the membrane in a calcium-dependent manner. Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner. Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin- dependent manner. Phosphorylated on serine and threonine residues. Belongs to the copine family. Sequence=BAD90244.1; Type=Erroneous initiation; Evidence=; protein serine/threonine kinase activity calcium-dependent phospholipid binding nucleus nucleolus cytoplasm mitochondrion cytosol plasma membrane focal adhesion protein phosphorylation membrane cell junction positive regulation of cell migration receptor tyrosine kinase binding ERBB2 signaling pathway calcium-dependent protein binding cellular response to calcium ion cellular response to growth factor stimulus uc008sby.1 uc008sby.2 uc008sby.3 
ENSMUST00000029888.4 Rmdn1 ENSMUST00000029888.4 regulator of microtubule dynamics 1 (from RefSeq NM_025476.6) A2AGJ3 A9UN01 ENSMUST00000029888.1 ENSMUST00000029888.2 ENSMUST00000029888.3 Fam82b NM_025476 Q8C0Y9 Q8R166 Q9CWS6 Q9DCV4 RMD1_MOUSE uc008sca.1 uc008sca.2 uc008sca.3 uc008sca.4 uc008sca.5 Interacts with microtubules. Cytoplasm Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Belongs to the RMDN family. spindle pole molecular_function cytoplasm mitochondrion spindle cytoskeleton microtubule biological_process uc008sca.1 uc008sca.2 uc008sca.3 uc008sca.4 uc008sca.5 
ENSMUST00000029891.12 Tmem68 ENSMUST00000029891.12 transmembrane protein 68, transcript variant 1 (from RefSeq NM_028097.4) DIESL_MOUSE ENSMUST00000029891.1 ENSMUST00000029891.10 ENSMUST00000029891.11 ENSMUST00000029891.2 ENSMUST00000029891.3 ENSMUST00000029891.4 ENSMUST00000029891.5 ENSMUST00000029891.6 ENSMUST00000029891.7 ENSMUST00000029891.8 ENSMUST00000029891.9 NM_028097 Q3UGT4 Q8BTV3 Q9D850 Tmem68 uc008rwh.1 uc008rwh.2 uc008rwh.3 Catalytic subunit of the alternative triglyceride biosynthesis pathway, which mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (By similarity). Synthesizes triacylglycerol at the expense of membrane phospholipids, such as phosphatidylcholine (PC) and its ether-linked form (ePC), thereby altering the composition of membranes (By similarity). The alternative triglyceride biosynthesis pathway is probably required to provide the energy required for rapid growth when fuel sources are limiting (PubMed:37648867). It maintains mitochondrial function during periods of extracellular lipid starvation (PubMed:37648867). Can also use acyl- CoA as donor: acts as a acyl-CoA:monoacylglycerol acyltransferase (MGAT), but also shows acyl-CoA:diacylglycerol acyltransferase (DGAT) activity (PubMed:36768334). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn- glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn- glycerol; Xref=Rhea:RHEA:32843, ChEBI:CHEBI:17815, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:64615; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32844; Evidence=; Reaction=a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA; Xref=Rhea:RHEA:16741, ChEBI:CHEBI:17389, ChEBI:CHEBI:49172, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; EC=2.3.1.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16742; Evidence=; Reaction=a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA; Xref=Rhea:RHEA:10868, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64615; EC=2.3.1.20; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10869; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:39951, ChEBI:CHEBI:52323, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:73990; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39952; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219, ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38220; Evidence=; Acyltransferase activity is specifically inhibited by TMX1 at the endoplasmic reticulum, restricting accumulation of triacylglycerol. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D850-1; Sequence=Displayed; Name=2; IsoId=Q9D850-2; Sequence=VSP_021247, VSP_021248; Widely expressed, with highest level in the brain, followed by lung and duodenum, and lowest levels in tongue, testis, skin and ileum. Mice are indistinguishable from their wild-type counterparts 1 week after birth but grow at a much slower rate between weeks 4 and 4 (PubMed:37648867). The weight difference observed after 4 weeks is maintained throughout adulthood, suggesting that it is required to support rapid growth at a specific time point after birth, which coincides with a dietary switch from milk to chow (PubMed:37648867). ells shown decreased triacylglycerol levels at 3.5 weeks of age (PubMed:37648867). Belongs to the diacylglycerol acyltransferase family. Highly divergent. molecular_function cellular_component biological_process membrane integral component of membrane transferase activity, transferring acyl groups uc008rwh.1 uc008rwh.2 uc008rwh.3 
ENSMUST00000029900.6 Atp6v0d2 ENSMUST00000029900.6 ATPase, H+ transporting, lysosomal V0 subunit D2 (from RefSeq NM_175406.3) ENSMUST00000029900.1 ENSMUST00000029900.2 ENSMUST00000029900.3 ENSMUST00000029900.4 ENSMUST00000029900.5 NM_175406 Q3TDQ6 Q5I0V5 Q80SY3 Q8BTL3 Q8BW16 VA0D2_MOUSE uc008sch.1 uc008sch.2 uc008sch.3 uc008sch.4 Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (PubMed:12963731). Regulator of osteoclast fusion and bone formation (PubMed:17128270). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Predominantly expressed in the kidney. Also expressed in the lung, testis, skeletal muscle and heart. Upr-egulated during osteoclast differentiation and is most abundant in mature osteoclasts. Strongly expressed at day 7 followed by a disappearance and a gradual recovery to original levels by day 17. Belongs to the V-ATPase V0D/AC39 subunit family. lysosomal membrane endosome early endosome ion transport vacuolar transport vacuolar acidification hydrogen-exporting ATPase activity, phosphorylative mechanism hydrogen ion transmembrane transporter activity membrane apical plasma membrane vacuolar proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V0 domain plasma membrane proton-transporting V-type ATPase complex proton-transporting ATPase activity, rotational mechanism hydrogen ion transmembrane transport uc008sch.1 uc008sch.2 uc008sch.3 uc008sch.4 
ENSMUST00000029905.2 Cyp7a1 ENSMUST00000029905.2 cytochrome P450, family 7, subfamily a, polypeptide 1 (from RefSeq NM_007824.3) CP7A1_MOUSE Cyp7 Cyp7a1 ENSMUST00000029905.1 NM_007824 Q64505 Q8BFR7 uc008rxk.1 uc008rxk.2 A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (Probable). 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol. Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (By similarity). Reaction=cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:21812, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:17500, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.23; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21813; Evidence=; Reaction=4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46120, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:85778, ChEBI:CHEBI:85779; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46121; Evidence=; Reaction=lathosterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53256, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17168, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:137063; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53257; Evidence=; Reaction=lathosterol + O2 + reduced [NADPH--hemoprotein reductase] = 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:53252, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17168, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:137062; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53253; Evidence=; Reaction=7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7-oxocholesterol + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:53248, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17759, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:64294; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53249; Evidence=; Reaction=(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46124, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:34310, ChEBI:CHEBI:37640, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.26; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46125; Evidence=; Reaction=(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:16093, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:50516, ChEBI:CHEBI:50518, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16094; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Lipid metabolism; bile acid biosynthesis. Steroid metabolism; cholesterol degradation. Endoplasmic reticulum membrane ; Single-pass membrane protein Microsome membrane ; Single-pass membrane protein Up-regulated by fasting, returns to ground state upon feeding. Up-regulated by experimentally induced diabetes. Down- regulated by insulin treatment. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process bile acid biosynthetic process cholesterol catabolic process cholesterol 7-alpha-monooxygenase activity steroid metabolic process cholesterol metabolic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding organelle membrane cholesterol homeostasis intracellular membrane-bounded organelle positive regulation of cholesterol biosynthetic process negative regulation of fatty acid biosynthetic process metal ion binding oxidation-reduction process regulation of bile acid biosynthetic process positive regulation of bile acid biosynthetic process cellular response to glucose stimulus cellular response to cholesterol uc008rxk.1 uc008rxk.2 
ENSMUST00000029907.6 Ubxn2b ENSMUST00000029907.6 UBX domain protein 2B (from RefSeq NM_026534.2) ENSMUST00000029907.1 ENSMUST00000029907.2 ENSMUST00000029907.3 ENSMUST00000029907.4 ENSMUST00000029907.5 NM_026534 Q0KL01 Q8BGY8 Q8CCQ0 Q9CZA8 UBX2B_MOUSE uc008rxj.1 uc008rxj.2 uc008rxj.3 Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Interacts with VCP. Does not bind ubiquitin. Nucleus Cytoplasm, cytosol Endoplasmic reticulum Golgi apparatus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to centrosome during mitotic prophase and metaphase. Belongs to the NSFL1C family. autophagosome assembly establishment of mitotic spindle orientation nucleus cytoplasm endoplasmic reticulum Golgi apparatus microtubule organizing center cytosol cytoskeleton Golgi organization nuclear envelope reassembly spindle pole centrosome ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of mitotic centrosome separation membrane fusion negative regulation of protein localization to centrosome uc008rxj.1 uc008rxj.2 uc008rxj.3 
ENSMUST00000029908.8 Faxc ENSMUST00000029908.8 failed axon connections homolog (from RefSeq NM_175234.4) ENSMUST00000029908.1 ENSMUST00000029908.2 ENSMUST00000029908.3 ENSMUST00000029908.4 ENSMUST00000029908.5 ENSMUST00000029908.6 ENSMUST00000029908.7 FAXC_MOUSE NM_175234 Q3UMF9 uc008sdl.1 uc008sdl.2 uc008sdl.3 uc008sdl.4 May play a role in axonal development. Membrane ; Single-pass membrane protein Belongs to the FAX family. molecular_function cellular_component biological_process membrane integral component of membrane uc008sdl.1 uc008sdl.2 uc008sdl.3 uc008sdl.4 
ENSMUST00000029909.3 Coq3 ENSMUST00000029909.3 coenzyme Q3 methyltransferase, transcript variant 1 (from RefSeq NM_172687.2) COQ3_MOUSE Coq3 ENSMUST00000029909.1 ENSMUST00000029909.2 NM_172687 Q3TCX5 Q6P918 Q8BM28 Q8BMS4 uc008sdj.1 uc008sdj.2 uc008sdj.3 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. Reaction=3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L- methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:44452, Rhea:RHEA- COMP:10930, Rhea:RHEA-COMP:10931, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64694, ChEBI:CHEBI:84443; EC=2.1.1.114; Evidence= Reaction=a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:44380, Rhea:RHEA- COMP:9566, Rhea:RHEA-COMP:10914, ChEBI:CHEBI:15378, ChEBI:CHEBI:17976, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:84422; EC=2.1.1.64; Evidence= Cofactor biosynthesis; ubiquinone biosynthesis. Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Mitochondrion inner membrane eripheral membrane protein atrix side Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. Sequence=BAC29030.1; Type=Erroneous initiation; Evidence=; hexaprenyldihydroxybenzoate methyltransferase activity mitochondrion mitochondrial inner membrane glycerol metabolic process ubiquinone biosynthetic process methyltransferase activity O-methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity 3-demethylubiquinone-9 3-O-methyltransferase activity polyprenyldihydroxybenzoate methyltransferase activity regulation of ubiquinone biosynthetic process membrane transferase activity extrinsic component of mitochondrial inner membrane methylation 3-demethylubiquinone-n 3-O-methyltransferase activity 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity uc008sdj.1 uc008sdj.2 uc008sdj.3 
ENSMUST00000029910.12 Nsmaf ENSMUST00000029910.12 neutral sphingomyelinase (N-SMase) activation associated factor, transcript variant 1 (from RefSeq NM_010945.3) A2AKK1 ENSMUST00000029910.1 ENSMUST00000029910.10 ENSMUST00000029910.11 ENSMUST00000029910.2 ENSMUST00000029910.3 ENSMUST00000029910.4 ENSMUST00000029910.5 ENSMUST00000029910.6 ENSMUST00000029910.7 ENSMUST00000029910.8 ENSMUST00000029910.9 FAN_MOUSE Fan NM_010945 O35242 uc012dai.1 uc012dai.2 uc012dai.3 uc012dai.4 Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N- SMASE. death receptor binding sphingomyelin phosphodiesterase activator activity positive regulation of apoptotic process positive regulation of catalytic activity uc012dai.1 uc012dai.2 uc012dai.3 uc012dai.4 
ENSMUST00000029911.12 Pnisr ENSMUST00000029911.12 PNN interacting serine/arginine-rich, transcript variant 1 (from RefSeq NM_025669.2) A2AJT5 A2AJT5_MOUSE ENSMUST00000029911.1 ENSMUST00000029911.10 ENSMUST00000029911.11 ENSMUST00000029911.2 ENSMUST00000029911.3 ENSMUST00000029911.4 ENSMUST00000029911.5 ENSMUST00000029911.6 ENSMUST00000029911.7 ENSMUST00000029911.8 ENSMUST00000029911.9 NM_025669 Pnisr uc008sdg.1 uc008sdg.2 uc008sdg.3 cytosol nuclear speck uc008sdg.1 uc008sdg.2 uc008sdg.3 
ENSMUST00000029915.6 Tstd3 ENSMUST00000029915.6 thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 (from RefSeq NM_029840.1) ENSMUST00000029915.1 ENSMUST00000029915.2 ENSMUST00000029915.3 ENSMUST00000029915.4 ENSMUST00000029915.5 NM_029840 Q9D0B5 TSTD3_MOUSE uc008scx.1 uc008scx.2 uc008scx.3 uc008scx.4 molecular_function thiosulfate sulfurtransferase activity cellular_component biological_process uc008scx.1 uc008scx.2 uc008scx.3 uc008scx.4 
ENSMUST00000029919.7 Clca1 ENSMUST00000029919.7 chloride channel accessory 1 (from RefSeq NM_017474.2) CLCA1_MOUSE Clca3 ENSMUST00000029919.1 ENSMUST00000029919.2 ENSMUST00000029919.3 ENSMUST00000029919.4 ENSMUST00000029919.5 ENSMUST00000029919.6 Gob5 NM_017474 O88826 Q8R049 Q9D7Z6 uc008rqf.1 uc008rqf.2 uc008rqf.3 uc008rqf.4 May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. Secreted, extracellular space te=The 75 kDa N-terminal and a 35 kDa C-terminal products are fully secreted into extracellular environment as a soluble complex of two glycoproteins. Exclusively expressed in the digestive and respiratory tracts and in the uterus (at protein level). Expressed in small intestine, colon, stomach, and uterus and slightly expressed in trachea tissue. Exclusively expressed in the mucin granule membranes of gastrointestinal, respiratory, and uterine goblet cells and other mucin-producing cells. In the colon, expressed in the surface mucous cells. In the stomach highly expressed in the surface epithelium in the pylorus. Strongly expressed in the airway epithelium of lung tissues associated with airway hyperresponsiveness (AHR). By IL3, IL4 and IL9 in the lung. Increases in the bronchiolar epithelium of asbestos-induced fibrogenesis. Decreases in cystic fibrosis knockout mice. The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates. The 110 kDa translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a 75 kDa N-terminal and a 35 kDa C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium- activated chloride channel (CaCC) activation activity. Glycosylated. Mice exhibit significantly increased bronchoalveolar lavage (BAL) inflammation consisted predominantly of neutrophils; have decreased goblet cell hyperplasia as well as decreased mucus production; have decreased airway hypersensitivity after cholinergic provocation with methacholine. Belongs to the CLCR family. intracellular calcium activated chloride channel activity chloride channel activity extracellular region extracellular space integral component of plasma membrane microvillus proteolysis ion transport calcium ion transport chloride transport peptidase activity metallopeptidase activity integral component of membrane hydrolase activity secretory granule ion transmembrane transport zymogen granule membrane metal ion binding cellular response to hypoxia chloride transmembrane transport uc008rqf.1 uc008rqf.2 uc008rqf.3 uc008rqf.4 
ENSMUST00000029925.10 Ndufaf4 ENSMUST00000029925.10 NADH:ubiquinone oxidoreductase complex assembly factor 4 (from RefSeq NM_026742.4) ENSMUST00000029925.1 ENSMUST00000029925.2 ENSMUST00000029925.3 ENSMUST00000029925.4 ENSMUST00000029925.5 ENSMUST00000029925.6 ENSMUST00000029925.7 ENSMUST00000029925.8 ENSMUST00000029925.9 Hrpap20 NDUF4_MOUSE NM_026742 Q3TV72 Q9D1H6 uc008sed.1 uc008sed.2 uc008sed.3 May be involved in cell proliferation and survival of hormone-dependent tumor cells. Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity). Binds calmodulin. Interacts with NDUFAF3. Mitochondrion Membrane ; Lipid-anchor Phosphorylated on serine. Prolactin stimulate serine phosphorylation (By similarity). Belongs to the NDUFAF4 family. molecular_function calmodulin binding mitochondrion positive regulation of cell proliferation NADH dehydrogenase complex assembly membrane mitochondrial membrane mitochondrial respiratory chain complex I assembly negative regulation of apoptotic process uc008sed.1 uc008sed.2 uc008sed.3 
ENSMUST00000029927.6 Spaca1 ENSMUST00000029927.6 sperm acrosome associated 1, transcript variant 1 (from RefSeq NM_026293.3) ENSMUST00000029927.1 ENSMUST00000029927.2 ENSMUST00000029927.3 ENSMUST00000029927.4 ENSMUST00000029927.5 NM_026293 Q9DA48 SACA1_MOUSE uc008sfz.1 uc008sfz.2 uc008sfz.3 Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane ; Single-pass type I membrane protein Note=Primarily found in the equatorial segment of the acrosome (PubMed:22949614). The tyrosine phosphorylated protein localizes to a smaller region within the equatorial segment (By similarity). Also expressed weakly in the principal segment (By similarity). Testis specific (at protein level). Detected in testis from 3 weeks of age onwards. N-glycosylated. Males are sterile, while female fertility is not affected. Spermatozoa have significantly impaired swimming ability. The sperm head has a rounded shape instead of the normal hook-shaped morphology. The acrosome membrane does not associate normally with the nuclear envelope or intermediate filament bundles, and fails to expand along the nuclear surface. The sperm nucleus remains globular and mitochondria appear disorganized. acrosome assembly inner acrosomal membrane acrosomal membrane spermatogenesis membrane integral component of membrane cytoplasmic vesicle uc008sfz.1 uc008sfz.2 uc008sfz.3 
ENSMUST00000029929.12 Clca3a2 ENSMUST00000029929.12 chloride channel accessory 3A2 (from RefSeq NM_030601.3) Clca2 Clca3a2 ENSMUST00000029929.1 ENSMUST00000029929.10 ENSMUST00000029929.11 ENSMUST00000029929.2 ENSMUST00000029929.3 ENSMUST00000029929.4 ENSMUST00000029929.5 ENSMUST00000029929.6 ENSMUST00000029929.7 ENSMUST00000029929.8 ENSMUST00000029929.9 NM_030601 Q9EQR4 Q9EQR4_MOUSE uc008rqa.1 uc008rqa.2 uc008rqa.3 Belongs to the CLCR family. intracellular calcium activated chloride channel activity integral component of plasma membrane chloride transport ion transmembrane transport anoikis extrinsic apoptotic signaling pathway in absence of ligand uc008rqa.1 uc008rqa.2 uc008rqa.3 
ENSMUST00000029936.5 Gbp2b ENSMUST00000029936.5 guanylate binding protein 2b (from RefSeq NM_010259.2) A4UUI2 A4UUI2_MOUSE ENSMUST00000029936.1 ENSMUST00000029936.2 ENSMUST00000029936.3 ENSMUST00000029936.4 Gbp2b NM_010259 uc008rox.1 uc008rox.2 uc008rox.3 Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. nucleotide binding GTPase activity GTP binding uc008rox.1 uc008rox.2 uc008rox.3 
ENSMUST00000029938.10 Gtf2b ENSMUST00000029938.10 general transcription factor IIB (from RefSeq NM_145546.1) ENSMUST00000029938.1 ENSMUST00000029938.2 ENSMUST00000029938.3 ENSMUST00000029938.4 ENSMUST00000029938.5 ENSMUST00000029938.6 ENSMUST00000029938.7 ENSMUST00000029938.8 ENSMUST00000029938.9 Gtf2b NM_145546 Q3ULN2 Q3ULN2_MOUSE uc008rpb.1 uc008rpb.2 uc008rpb.3 uc008rpb.4 Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; Chromosome Belongs to the TFIIB family. RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II core binding core promoter binding transcriptional start site selection at RNA polymerase II promoter nucleus transcription factor TFIID complex chromosome regulation of transcription, DNA-templated transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter protein acetylation transcription factor binding zinc ion binding obsolete general RNA polymerase II transcription factor activity acetyltransferase activity nuclear body TBP-class protein binding protein-DNA complex positive regulation by host of viral transcription metal ion binding thyroid hormone receptor binding positive regulation of viral transcription RNA polymerase II transcriptional preinitiation complex assembly positive regulation of transcription initiation from RNA polymerase II promoter DNA-templated transcriptional preinitiation complex assembly RNA polymerase II transcription factor complex transcriptional preinitiation complex positive regulation of core promoter binding RNA Polymerase II core complex assembly promoter-specific chromatin binding uc008rpb.1 uc008rpb.2 uc008rpb.3 uc008rpb.4 
ENSMUST00000029941.16 Pdlim5 ENSMUST00000029941.16 PDZ and LIM domain 5, transcript variant 1 (from RefSeq NM_019808.3) ENSMUST00000029941.1 ENSMUST00000029941.10 ENSMUST00000029941.11 ENSMUST00000029941.12 ENSMUST00000029941.13 ENSMUST00000029941.14 ENSMUST00000029941.15 ENSMUST00000029941.2 ENSMUST00000029941.3 ENSMUST00000029941.4 ENSMUST00000029941.5 ENSMUST00000029941.6 ENSMUST00000029941.7 ENSMUST00000029941.8 ENSMUST00000029941.9 Enh NM_019808 PDLI5_MOUSE Pdlim5 Q3UGD0 Q8CI51 Q9QYN0 Q9QYN1 Q9QYN2 uc008rol.1 uc008rol.2 uc008rol.3 uc008rol.4 May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. Interacts with various PKC isoforms through the LIM domains. Interacts with actin and alpha-actinin through the PDZ domain. Interacts (via LIM domains) with SIPA1L1/SPAR; this interaction may occur preferentially with isoform 1. Postsynaptic density Presynapse Postsynapse Cytoplasm, cytosol Note=Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=ENH1; IsoId=Q8CI51-1; Sequence=Displayed; Name=2; Synonyms=ENH2; IsoId=Q8CI51-2; Sequence=VSP_010469, VSP_010470; Name=3; Synonyms=ENH3; IsoId=Q8CI51-3; Sequence=VSP_010467, VSP_010468, VSP_010469, VSP_010470; stress fiber actin binding protein kinase C binding protein binding cytoplasm cytosol plasma membrane cell-cell adherens junction heart development postsynaptic density actin cytoskeleton membrane Z disc actin cytoskeleton organization cell junction filamentous actin actinin binding neuron projection synapse postsynaptic membrane metal ion binding protein N-terminus binding muscle alpha-actinin binding regulation of synapse assembly regulation of dendritic spine morphogenesis cell growth involved in cardiac muscle cell development muscle structure development uc008rol.1 uc008rol.2 uc008rol.3 uc008rol.4 
ENSMUST00000029947.6 Gabrr1 ENSMUST00000029947.6 gamma-aminobutyric acid type A receptor subunit rho 1 (from RefSeq NM_008075.2) A3KG51 ENSMUST00000029947.1 ENSMUST00000029947.2 ENSMUST00000029947.3 ENSMUST00000029947.4 ENSMUST00000029947.5 GBRR1_MOUSE NM_008075 P56475 uc008sfr.1 uc008sfr.2 uc008sfr.3 uc008sfr.4 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 (By similarity). Postsynaptic cell membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub- subfamily. Sequence=AAB81964.1; Type=Erroneous initiation; Evidence=; Sequence=CAM45896.1; Type=Erroneous initiation; Evidence=; transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction chemical synaptic transmission membrane integral component of membrane GABA receptor activity protein domain specific binding cell junction ion transmembrane transport chloride channel complex regulation of membrane potential protein homodimerization activity neuron projection synapse postsynaptic membrane protein heterodimerization activity neurological system process regulation of postsynaptic membrane potential glutamatergic synapse GABA-ergic synapse regulation of presynaptic membrane potential ligand-gated ion channel activity involved in regulation of presynaptic membrane potential chloride transmembrane transport transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc008sfr.1 uc008sfr.2 uc008sfr.3 uc008sfr.4 
ENSMUST00000029955.5 1700009N14Rik ENSMUST00000029955.5 RIKEN cDNA 1700009N14 gene (from RefSeq NM_001081095.1) 1700009N14Rik ENSMUST00000029955.1 ENSMUST00000029955.2 ENSMUST00000029955.3 ENSMUST00000029955.4 NM_001081095 Q14AA6 Q14AA6_MOUSE uc008shc.1 uc008shc.2 uc008shc.3 uc008shc.4 GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Nucleus Belongs to the small GTPase superfamily. Ran family. nucleotide binding GTPase activity GTP binding nucleus cytoplasm protein import into nucleus nucleocytoplasmic transport protein transport protein domain specific binding uc008shc.1 uc008shc.2 uc008shc.3 uc008shc.4 
ENSMUST00000029964.12 Epha7 ENSMUST00000029964.12 Eph receptor A7, transcript variant 1 (from RefSeq NM_010141.5) ENSMUST00000029964.1 ENSMUST00000029964.10 ENSMUST00000029964.11 ENSMUST00000029964.2 ENSMUST00000029964.3 ENSMUST00000029964.4 ENSMUST00000029964.5 ENSMUST00000029964.6 ENSMUST00000029964.7 ENSMUST00000029964.8 ENSMUST00000029964.9 EPHA7_MOUSE Ebk Ehk3 Mdk1 NM_010141 Q61505 Q61772 Q61773 Q61774 Q8BSU8 uc008sen.1 uc008sen.2 uc008sen.3 uc008sen.4 uc008sen.5 Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4 which lacks the kinase domain may regulate isoform 1 adhesive properties. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain). Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=MDK1, EPHA7-FL; IsoId=Q61772-1; Sequence=Displayed; Name=2; Synonyms=MDK1-1, Ebk-td1; IsoId=Q61772-2; Sequence=VSP_003006; Name=3; Synonyms=MDK1-2; IsoId=Q61772-3; Sequence=VSP_003007; Name=4; Synonyms=MDK1-T1, EPHA7-T1; IsoId=Q61772-4; Sequence=VSP_003008, VSP_003009; Name=5; Synonyms=MDK1-T2, EPHA7-T2; IsoId=Q61772-5; Sequence=VSP_003010, VSP_003011; Widely expressed in embryo. In adult, expression restricted to hippocampus, testis and spleen. Expressed in myogenic progenitor cells (PubMed:27446912). During visual system development, expressed in an anterior to posterior decreasing gradient stretching through the entire midbrain. This gradient has the reverse orientation to the one defined by the expression of ephrins. Isoform 4 and isoform 5 are expressed at the edges of the embryonic cranial neural fold. In myogenic progenitor cells, highly expressed, at least as early as 11.5 dpc, expression decreases until 4 weeks after birth (PubMed:27446912). Phosphorylated. Isoform 4 inhibits isoform 1 phosphorylation and may regulate its function in adhesion. Mice are viable, fertile and show no gross morphological or behavioral defects. However, topographic targeting errors of nasal and temporal retinal axons appear during development of the retinocollicular projections in the visual system. 10 percent of the embryos also display exencephalic overgrowth of forebrain tissues which might be the result of reduced apoptosis. [Isoform 4]: Truncated receptor lacking the kinase domain. [Isoform 5]: Truncated receptor lacking the kinase domain. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. nucleotide binding positive regulation of protein phosphorylation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity GPI-linked ephrin receptor activity transmembrane-ephrin receptor activity protein binding ATP binding plasma membrane integral component of plasma membrane protein phosphorylation apoptotic process transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development axon guidance brain development axon guidance receptor activity membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation regulation of cell-cell adhesion dendrite retinal ganglion cell axon guidance neuromuscular junction regulation of protein autophosphorylation neuron projection neuronal cell body positive regulation of apoptotic process receptor complex regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of neuron apoptotic process postsynaptic membrane chemorepellent activity ephrin receptor binding ephrin receptor signaling pathway negative regulation of collateral sprouting branching morphogenesis of a nerve regulation of peptidyl-tyrosine phosphorylation negative chemotaxis negative regulation of synapse assembly regulation of ERK1 and ERK2 cascade nephric duct morphogenesis glutamatergic synapse integral component of postsynaptic specialization membrane integral component of postsynaptic density membrane uc008sen.1 uc008sen.2 uc008sen.3 uc008sen.4 uc008sen.5 
ENSMUST00000029968.14 Rars2 ENSMUST00000029968.14 arginyl-tRNA synthetase 2, mitochondrial, transcript variant 2 (from RefSeq NR_151507.1) ENSMUST00000029968.1 ENSMUST00000029968.10 ENSMUST00000029968.11 ENSMUST00000029968.12 ENSMUST00000029968.13 ENSMUST00000029968.2 ENSMUST00000029968.3 ENSMUST00000029968.4 ENSMUST00000029968.5 ENSMUST00000029968.6 ENSMUST00000029968.7 ENSMUST00000029968.8 ENSMUST00000029968.9 NR_151507 Q3U186 Q8QZU7 Rarsl SYRM_MOUSE uc008sgf.1 uc008sgf.2 uc008sgf.3 uc008sgf.4 Catalyzes the attachment of arginine to tRNA(Arg) in a two- step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg). Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl- tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA- COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215; EC=6.1.1.19; Evidence=; Mitochondrion membrane Belongs to the class-I aminoacyl-tRNA synthetase family. nucleotide binding aminoacyl-tRNA ligase activity arginine-tRNA ligase activity ATP binding cytoplasm mitochondrion mitochondrial matrix translation tRNA aminoacylation for protein translation arginyl-tRNA aminoacylation ligase activity mitochondrial translation uc008sgf.1 uc008sgf.2 uc008sgf.3 uc008sgf.4 
ENSMUST00000029970.14 Slc35a1 ENSMUST00000029970.14 solute carrier family 35 (CMP-sialic acid transporter), member 1, transcript variant 3 (from RefSeq NM_011895.4) A2AT44 ENSMUST00000029970.1 ENSMUST00000029970.10 ENSMUST00000029970.11 ENSMUST00000029970.12 ENSMUST00000029970.13 ENSMUST00000029970.2 ENSMUST00000029970.3 ENSMUST00000029970.4 ENSMUST00000029970.5 ENSMUST00000029970.6 ENSMUST00000029970.7 ENSMUST00000029970.8 ENSMUST00000029970.9 NM_011895 Q61420 S35A1_MOUSE Slc35a1 uc012dbo.1 uc012dbo.2 Transports CMP-sialic acid from the cytosol into the Golgi apparatus, functioning as an antiporter that exchanges CMP-sialic acid for CMP (PubMed:8755516, PubMed:10085119, PubMed:30985278, PubMed:34015330). Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (PubMed:30985278). Also able to exchange CMP-sialic acid for AMP and UMP (By similarity). Also mediates the transport of CDP-ribitol (PubMed:34015330) (By similarity). Reaction=CMP(out) + CMP-N-acetyl-beta-neuraminate(in) = CMP(in) + CMP- N-acetyl-beta-neuraminate(out); Xref=Rhea:RHEA:67724, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377; Evidence= Reaction=AMP(out) + CMP-N-acetyl-beta-neuraminate(in) = AMP(in) + CMP- N-acetyl-beta-neuraminate(out); Xref=Rhea:RHEA:74639, ChEBI:CHEBI:57812, ChEBI:CHEBI:456215; Evidence=; Reaction=CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out); Xref=Rhea:RHEA:71579, ChEBI:CHEBI:57608, ChEBI:CHEBI:58069; Evidence=; Reaction=CMP-N-acetyl-beta-neuraminate(in) + UMP(out) = CMP-N-acetyl- beta-neuraminate(out) + UMP(in); Xref=Rhea:RHEA:74643, ChEBI:CHEBI:57812, ChEBI:CHEBI:57865; Evidence=; Kinetic parameters: KM=13.2 uM for CMP-N-acetyl-beta-neuraminate ; Vmax=6.5 nmol/min/mol enzyme for CMP-N-acetyl-beta-neuraminate ; Monomer. Golgi apparatus membrane ulti-pass membrane protein Ubiquitous. Found in all the tissues examined including skeletal muscle, brain, heart, liver, kidney and spleen. Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. Golgi membrane CMP-N-acetylneuraminate transmembrane transporter activity UDP-galactose transmembrane transporter activity Golgi apparatus carbohydrate transport pyrimidine nucleotide-sugar transmembrane transporter activity antiporter activity CMP-N-acetylneuraminate transport membrane integral component of membrane integral component of Golgi membrane UDP-galactose transmembrane transport pyrimidine nucleotide-sugar transmembrane transport uc012dbo.1 uc012dbo.2 
ENSMUST00000029971.12 Cfap206 ENSMUST00000029971.12 cilia and flagella associated protein 206, transcript variant 1 (from RefSeq NM_001347062.1) A2AT45 A2AT46 A2AT47 CF206_MOUSE Cfap206 ENSMUST00000029971.1 ENSMUST00000029971.10 ENSMUST00000029971.11 ENSMUST00000029971.2 ENSMUST00000029971.3 ENSMUST00000029971.4 ENSMUST00000029971.5 ENSMUST00000029971.6 ENSMUST00000029971.7 ENSMUST00000029971.8 ENSMUST00000029971.9 NM_001347062 Q6PE87 Q9DAP6 uc057lhj.1 uc057lhj.2 uc057lhj.3 [Isoform 1]: Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (PubMed:32376681). Required for the establishment of radial spokes in sperm flagella (PubMed:32376681). [Isoform 2]: Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (PubMed:32376681). Required for the establishment of radial spokes in sperm flagella (PubMed:32376681). Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, cilium basal body Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PE87-1; Sequence=Displayed; Name=2; IsoId=Q6PE87-2; Sequence=VSP_036124, VSP_036125; [Isoform 1]: Expressed in the sperm, oviduct, lung, nasal cavity, brain ependyma and choroid plexus. [Isoform 2]: Expressed in the sperm, oviduct, lung, nasal cavity, brain ependyma and choroid plexus. Expressed in the left-right organiser at embryonic day 8.0 dpc and at 17.5 dpc, expressed in the airway epithelia and brain ependymal tissues. Mice postnatally develop hydrocephalus, show impaired mucociliary clearance of the airways and are characterized by male infertility. Belongs to the CFAP206 family. Sequence=AAH58220.1; Type=Erroneous initiation; Evidence=; Sequence=BAB24168.1; Type=Erroneous initiation; Evidence=; Sequence=CAM26878.1; Type=Erroneous gene model prediction; Evidence=; radial spoke cilium movement molecular_function cellular_component cytoplasm cytoskeleton cilium biological_process cell projection organization motile cilium axoneme assembly cell projection A axonemal microtubule uc057lhj.1 uc057lhj.2 uc057lhj.3 
ENSMUST00000029972.4 Smim8 ENSMUST00000029972.4 small integral membrane protein 8, transcript variant 4 (from RefSeq NM_001330757.1) ENSMUST00000029972.1 ENSMUST00000029972.2 ENSMUST00000029972.3 NM_001330757 Q9CQQ0 Q9CY70 SMIM8_MOUSE uc008sgm.1 uc008sgm.2 uc008sgm.3 Membrane ; Single-pass membrane protein Belongs to the SMIM8 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008sgm.1 uc008sgm.2 uc008sgm.3 
ENSMUST00000029975.10 Cga ENSMUST00000029975.10 glycoprotein hormones, alpha subunit (from RefSeq NM_009889.2) ENSMUST00000029975.1 ENSMUST00000029975.2 ENSMUST00000029975.3 ENSMUST00000029975.4 ENSMUST00000029975.5 ENSMUST00000029975.6 ENSMUST00000029975.7 ENSMUST00000029975.8 ENSMUST00000029975.9 GLHA_MOUSE NM_009889 P01216 P11963 Q5M8P4 uc008sgq.1 uc008sgq.2 uc008sgq.3 Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin. Secreted Expressed in the ventral area of the anterior pituitary gland from 13.5 dpc onwards, expression remains at 18.5 dpc. Belongs to the glycoprotein hormones subunit alpha family. PubMed:6177696 sequence was originally thought to originate from rat. hormone activity extracellular region extracellular space thyroid hormone generation G-protein coupled receptor signaling pathway gonad development regulation of receptor activity positive regulation of steroid biosynthetic process follicle-stimulating hormone activity follicle-stimulating hormone complex thyroid gland development luteinizing hormone secretion cellular response to hormone stimulus negative regulation of organ growth follicle-stimulating hormone secretion developmental growth uc008sgq.1 uc008sgq.2 uc008sgq.3 
ENSMUST00000029987.10 Aldob ENSMUST00000029987.10 aldolase B, fructose-bisphosphate (from RefSeq NM_144903.3) ALDOB_MOUSE Aldo2 Aldob ENSMUST00000029987.1 ENSMUST00000029987.2 ENSMUST00000029987.3 ENSMUST00000029987.4 ENSMUST00000029987.5 ENSMUST00000029987.6 ENSMUST00000029987.7 ENSMUST00000029987.8 ENSMUST00000029987.9 NM_144903 Q8K034 Q91W73 Q91Y97 uc008svw.1 uc008svw.2 uc008svw.3 uc008svw.4 This gene encodes a subunit of the homotetrameric enzyme aldolase B, an isozyme of the class I fructose 1,6-bisphosphate aldolase enzyme. This enzyme catalyzes the conversion of fructose 1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Homozygous knockout mice for this gene exhibit liver damage and death following fructose ingestion. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149395.1, AK167566.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D- glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:25637246). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3- phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729, ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=4.1.2.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14730; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:14731; Evidence=; Reaction=beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate; Xref=Rhea:RHEA:30851, ChEBI:CHEBI:17378, ChEBI:CHEBI:57642, ChEBI:CHEBI:138881; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30852; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:30853; Evidence=; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 4/4. Carbohydrate biosynthesis; gluconeogenesis. Carbohydrate metabolism; fructose metabolism. Homotetramer. Interacts with BBS1, BBS2, BBS4 and BBS7. Forms a ternary complex with G6PD and TP53; this interaction is direct. Cytoplasm, cytosol Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Mice are born at the expected Mendelian rate. On a fructose diet, they develop fructose intolerance associated with hepatic steatosis and mortality. In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain. Belongs to the class I fructose-bisphosphate aldolase family. catalytic activity fructose-bisphosphate aldolase activity nucleus cytoplasm lysosome microtubule organizing center cytosol cytoskeleton plasma membrane fructose metabolic process glycolytic process NADH oxidation cytoskeletal protein binding response to zinc ion lyase activity fructose 1,6-bisphosphate metabolic process rough endoplasmic reticulum membrane smooth endoplasmic reticulum membrane phosphatidylcholine binding positive regulation of ATPase activity centriolar satellite identical protein binding intracellular membrane-bounded organelle response to peptide hormone perinuclear region of cytoplasm ATPase binding fructose-1-phosphate aldolase activity glycolytic process through fructose-6-phosphate fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate glycolytic process through fructose-1-phosphate fructose binding vacuolar proton-transporting V-type ATPase complex assembly uc008svw.1 uc008svw.2 uc008svw.3 uc008svw.4 
ENSMUST00000029991.3 Ppp3r2 ENSMUST00000029991.3 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) (from RefSeq NM_001004025.4) CANB2_MOUSE ENSMUST00000029991.1 ENSMUST00000029991.2 NM_001004025 Q63811 uc008swd.1 uc008swd.2 uc008swd.3 Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2) (By similarity). Interacts with SPATA33 (via PQIIIT motif) (PubMed:34446558). Mitochondrion Note=Localizes in the mitochondria in a SPATA33-dependent manner. Expressed in osteoblasts and bone marrow (at protein level) (PubMed:16286645). Expressed in the testis (PubMed:1325794, PubMed:34446558). Expressed in the sperm midpiece in a SPATA33-dependent manner (at protein level) (PubMed:34446558). This protein has four functional calcium-binding sites. Belongs to the calcineurin regulatory subunit family. calcium-dependent protein serine/threonine phosphatase activity calcium ion binding glycogen metabolic process protein dephosphorylation defense response sperm displacement metal ion binding uc008swd.1 uc008swd.2 uc008swd.3 
ENSMUST00000029995.6 Toporsl ENSMUST00000029995.6 topoisomerase I binding, arginine/serine-rich like, transcript variant 1 (from RefSeq NM_026652.3) 4930547C10Rik ENSMUST00000029995.1 ENSMUST00000029995.2 ENSMUST00000029995.3 ENSMUST00000029995.4 ENSMUST00000029995.5 NM_026652 Q9D2F8 Q9D2F8_MOUSE Toporsl uc008swm.1 uc008swm.2 uc008swm.3 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; protein polyubiquitination cellular_component protein monoubiquitination ubiquitin protein ligase activity uc008swm.1 uc008swm.2 uc008swm.3 
ENSMUST00000030003.10 Exosc3 ENSMUST00000030003.10 exosome component 3, transcript variant 1 (from RefSeq NM_025513.4) ENSMUST00000030003.1 ENSMUST00000030003.2 ENSMUST00000030003.3 ENSMUST00000030003.4 ENSMUST00000030003.5 ENSMUST00000030003.6 ENSMUST00000030003.7 ENSMUST00000030003.8 ENSMUST00000030003.9 EXOS3_MOUSE NM_025513 Q7TQK4 Q9CV81 Q9CVW2 Rrp40 uc008ssk.1 uc008ssk.2 uc008ssk.3 uc008ssk.4 Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5 (By similarity). Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with GTPBP1 (By similarity). Interacts with ZC3HAV1 (By similarity). Interacts with DDX17 only in the presence of ZC3HAV1 in an RNA-independent manner (By similarity). Interacts with DHX36; this interaction occurs in a RNase-insensitive manner (By similarity). Cytoplasm Nucleus, nucleolus Nucleus Belongs to the RRP40 family. nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA binding nuclease activity exonuclease activity nucleus nucleoplasm nucleolus cytoplasm rRNA processing hydrolase activity nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U4 snRNA 3'-end processing transcriptionally active chromatin exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay DNA deamination isotype switching positive regulation of isotype switching CUT catabolic process nuclear polyadenylation-dependent rRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription polyadenylation-dependent snoRNA 3'-end processing uc008ssk.1 uc008ssk.2 uc008ssk.3 uc008ssk.4 
ENSMUST00000030010.4 Abca1 ENSMUST00000030010.4 ATP-binding cassette, sub-family A member 1 (from RefSeq NM_013454.3) ABCA1_MOUSE Abc1 Abca1 B1AWZ8 ENSMUST00000030010.1 ENSMUST00000030010.2 ENSMUST00000030010.3 NM_013454 P41233 uc008swu.1 uc008swu.2 uc008swu.3 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain. Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38583, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57643, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38585; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38567, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57262, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38569; Evidence=; Reaction=a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38903, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38904; Evidence=; Reaction=ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate; Xref=Rhea:RHEA:39051, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39052; Evidence=; ATPase activity is decreased by cholesterol and ceramide. ATPase activity is stimulated by phosphatidylcholine and to a lesser degree by phosphatidylserine and sphingomyelin. Phospholipid translocase activity is highly reduced by berylium fluoride and aluminum flouride and reduced by N-ethylmaleimide. Interacts with MEGF10 (PubMed:17205124). May interact with APOE1; functionally associated with APOE1 in the biogenesis of HDLs (By similarity). Interacts with ABCA8; this interaction potentiates cholesterol efflux (By similarity). Interacts with ABCA12 and NR1H2; this interaction is required for ABCA1 localization to the cell surface and is necessary for its normal activity and stability (By similarity). Cell membrane ; Multi-pass membrane protein Endosome Widely expressed in adult tissues. Highest levels are found in pregnant uterus and uterus. Down-regulated by endotoxins (LPS) or cytokines (TNF and IL- 1) in J774 macrophages. The down-regulation by endotoxin in macrophages is not likely to be mediated by the liver X receptor/retinoic X receptor (LXR/RXR). Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylated by ZDHHC8. Palmitoylation is essential for localization to the plasma membrane. Belongs to the ABC transporter superfamily. ABCA family. Sequence=AAG39073.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAA53530.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding peptide secretion receptor binding lipid transporter activity protein binding ATP binding phospholipid transporter activity endosome Golgi apparatus plasma membrane integral component of plasma membrane protein lipidation lipid transport phagocytosis, engulfment lysosome organization G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway response to nutrient high-density lipoprotein particle binding cholesterol metabolic process external side of plasma membrane cell surface positive regulation of cholesterol efflux phospholipid transport membrane integral component of membrane endosomal transport ATPase activity syntaxin binding endocytic vesicle cholesterol transport phosphatidylcholine binding small GTPase binding intracellular cholesterol transport regulation of Cdc42 protein signal transduction cholesterol efflux phospholipid efflux apolipoprotein binding apolipoprotein A-I binding apolipoprotein A-I receptor activity high-density lipoprotein particle assembly response to laminar fluid shear stress apolipoprotein A-I-mediated signaling pathway lipoprotein metabolic process lipoprotein biosynthetic process response to drug ATPase activity, coupled to transmembrane movement of substances cholesterol homeostasis intracellular membrane-bounded organelle reverse cholesterol transport membrane raft phospholipid translocation phagocytic vesicle perinuclear region of cytoplasm interleukin-1 beta secretion ATPase binding transmembrane transport phospholipid homeostasis platelet dense granule organization cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to cholesterol cellular response to low-density lipoprotein particle stimulus positive regulation of high-density lipoprotein particle assembly phosphatidylcholine-translocating ATPase activity phosphatidylserine-translocating ATPase activity cellular response to high density lipoprotein particle stimulus uc008swu.1 uc008swu.2 uc008swu.3 
ENSMUST00000030013.12 Xpa ENSMUST00000030013.12 xeroderma pigmentosum, complementation group A, transcript variant 7 (from RefSeq NR_188968.1) A2ALZ7 ENSMUST00000030013.1 ENSMUST00000030013.10 ENSMUST00000030013.11 ENSMUST00000030013.2 ENSMUST00000030013.3 ENSMUST00000030013.4 ENSMUST00000030013.5 ENSMUST00000030013.6 ENSMUST00000030013.7 ENSMUST00000030013.8 ENSMUST00000030013.9 NR_188968 Q64267 Q9CVA0 XPA_MOUSE Xpac uc008stm.1 uc008stm.2 uc008stm.3 Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (By similarity). Interacts with GPN1. Interacts with RPA1 and RPA2; the interaction is direct and associates XPA with the RPA complex. Interacts (via N-terminus) with CEP164 upon UV irradiation. Interacts with HERC2 (By similarity). Nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q64267-1; Sequence=Displayed; Name=2; IsoId=Q64267-2; Sequence=VSP_036906; Exhibits a circadian pattern with zenith at around 5 pm and nadir at around 5 am in liver but not in testis, this oscillation is dependent on the circadian clock and on HERC2 regulation. Ubiquitinated by HERC2 leading to degradation by the proteasome. Deficient mice cannot repair UV-induced DNA damage and easily develop skin cancers by UV irradiation. They develop stronger longer-lasting acute inflammation, they show a more severe UV- induced damage of keratinocytes and Langerhans cells as well as the enhancement of local and systemic immunosuppression. PGE2 and COX2 expression is greatly increased after UVB irradiation, this causes the enhancement of inflammation and immunosuppression. Natural killer cell activity is also significantly decreased (PubMed:11764287). Knockout in a Polr2a 'R-1268' knockin mouse leads to growth retardation, skeletal abnormalities, cataracts, progressive motor neuron degeneration and death at 5-6 months (PubMed:32142649). Plays an essential role in the repair of cisplatin induced damage by nucleotide excision repair. Cisplatin is one of the most commnly used anticancer drugs. Belongs to the XPA family. nucleotide-excision repair factor 1 complex nucleotide-excision repair, DNA damage recognition DNA binding damaged DNA binding nucleus DNA replication factor A complex cytoplasm DNA repair base-excision repair nucleotide-excision repair cellular response to DNA damage stimulus response to oxidative stress intrinsic apoptotic signaling pathway in response to DNA damage response to UV response to toxic substance UV protection regulation of autophagy protein domain specific binding nucleotide-excision repair, DNA incision protein localization to nucleus multicellular organism growth protein homodimerization activity intercellular bridge metal ion binding UV-damage excision repair nucleotide-excision repair involved in interstrand cross-link repair uc008stm.1 uc008stm.2 uc008stm.3 
ENSMUST00000030014.9 Ncbp1 ENSMUST00000030014.9 nuclear cap binding protein subunit 1, transcript variant 3 (from RefSeq NM_001425041.1) B1AWH4 Cbp80 ENSMUST00000030014.1 ENSMUST00000030014.2 ENSMUST00000030014.3 ENSMUST00000030014.4 ENSMUST00000030014.5 ENSMUST00000030014.6 ENSMUST00000030014.7 ENSMUST00000030014.8 NCBP1_MOUSE NM_001425041 Q3TEM1 Q3UYV9 Q7TNE8 uc008stk.1 uc008stk.2 uc008stk.3 uc008stk.4 Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability (By similarity). Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20 that interacts with m7GpppG-capped RNA. Found in a U snRNA export complex containing PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with PHAX/RNUXA, SRRT/ARS2, EIF4G2, IGF2BP1, HNRNPF, HNRNPH1, KIAA0427/CTIF, PARN, DROSHA, UPF1 and ALYREF/THOC4. May interact with EIF4G1; the interaction is however controversial. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1/CBP80 and POLR2A (active). Component of an alternative nuclear cap-binding complex (CBC) composed of NCBP1/CBP80 and NCBP3 (By similarity). Interacts with METTL3 (By similarity). Interacts with ZFC3H1 in a RNase-insensitive manner (By similarity). Interacts with MTREX (By similarity). Interacts with TASOR (PubMed:31112734). Interacts with DHX34; the interaction is RNA-dependent (By similarity). Interacts with KPNA3 (By similarity). Nucleus Cytoplasm Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the spermatogonia, spermatocytes and granular cells within the cerebellum. Belongs to the NCBP1 family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay spliceosomal complex assembly RNA cap binding RNA 7-methylguanosine cap binding RNA binding mRNA binding protein binding nucleus nucleoplasm cytoplasm mitochondrion cytosol mRNA cap binding complex nuclear cap binding complex 7-methylguanosine mRNA capping mRNA processing mRNA export from nucleus regulation of translation regulation of translational initiation RNA splicing RNA metabolic process positive regulation of cell growth gene silencing by RNA positive regulation of mRNA 3'-end processing RNA cap binding complex mRNA cis splicing, via spliceosome positive regulation of mRNA splicing, via spliceosome regulation of mRNA processing mRNA transport pre-mRNA cleavage required for polyadenylation positive regulation of RNA binding ribonucleoprotein complex regulation of mRNA polyadenylation uc008stk.1 uc008stk.2 uc008stk.3 uc008stk.4 
ENSMUST00000030018.5 Nans ENSMUST00000030018.5 N-acetylneuraminic acid synthase (sialic acid synthase), transcript variant 1 (from RefSeq NM_053179.4) ENSMUST00000030018.1 ENSMUST00000030018.2 ENSMUST00000030018.3 ENSMUST00000030018.4 NM_053179 Nans Q99J77 Q9JJH0 SIAS_MOUSE Sas uc008stv.1 uc008stv.2 uc008stv.3 Produces N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) from N- acetylmannosamine 6-phosphate. Has no detectable activity towards N- acetylmannosamine or mannose 6-phosphate. Reaction=an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate = an N-acylneuraminate 9-phosphate + phosphate; Xref=Rhea:RHEA:13421, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57537, ChEBI:CHEBI:57666, ChEBI:CHEBI:58702; EC=2.5.1.57; Evidence=; Cytoplasm Ubiquitous. catalytic activity cytoplasm cytosol carbohydrate biosynthetic process transferase activity N-acylneuraminate-9-phosphate synthase activity uc008stv.1 uc008stv.2 uc008stv.3 
ENSMUST00000030025.10 Nr4a3 ENSMUST00000030025.10 nuclear receptor subfamily 4, group A, member 3, transcript variant 1 (from RefSeq NM_015743.3) ENSMUST00000030025.1 ENSMUST00000030025.2 ENSMUST00000030025.3 ENSMUST00000030025.4 ENSMUST00000030025.5 ENSMUST00000030025.6 ENSMUST00000030025.7 ENSMUST00000030025.8 ENSMUST00000030025.9 NM_015743 NR4A3_MOUSE Q9QZB5 Q9QZB6 Tec uc008suu.1 uc008suu.2 uc008suu.3 uc008suu.4 This gene encodes a member of the NR4A subfamily of nuclear hormone receptors that bind to DNA and modulate gene expression. The encoded protein has been implicated in T and B lymphocyte apoptosis, and immune cell proliferation. Mice lacking the encoded protein exhibit partial bidirectional circling behavior and inner ear dysfunction. Disruption of this gene in mice also results in defective hippocampal axonal growth and postnatal neuronal cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner (PubMed:12709428). Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (PubMed:21868379). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner (PubMed:24806827). During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (PubMed:11784868). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance (PubMed:20566846, PubMed:15456880). Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (PubMed:19153266). Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (PubMed:24586680). Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1 (PubMed:23897430, PubMed:19523439). Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (PubMed:18325999). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (By similarity). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration (PubMed:13129926). Inhibits adipogenesis (PubMed:18945812). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). Interacts with SIX3 (via homeobox); differentially regulates the transcriptional activities of NR4A3. Interacts with NCOA2; potentiates the activity of the NR4A3 (PubMed:12709428). Interacts with NCOA1, NCOA3, MED1 and KAT2B. Interacts with EP300 and NCOA2; mediates the recruitment of MED1 in the coactivator complex (PubMed:12709428). Interacts with the constituents of DNA-PK heterotrimer PRKDC, XRCC6 and XRCC5; phosphorylates and prevents NR4A3 ubiquitinylation and degradation (By similarity). Interacts with NR3C1 (via nuclear receptor DNA-binding domain); the interactions represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE). Interacts with TRIM28; the interactions potentiates NR4A3 activity on NurRE promoter. Binds DNA as a monomer and homodimer. Interacts with PARP1; activates PARP1 by improving acetylation of PARP1 and suppressing the interaction between PARP1 and SIRT1 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=Q9QZB6-1; Sequence=Displayed; Name=2; Synonyms=Short, TECdeltaC; IsoId=Q9QZB6-2; Sequence=VSP_010083, VSP_010084; Ubiquitous. Highest levels of expression in brain. Widely expressed throughout the arcuate nucleus region of the hypothalamus, namely in AgRP neurons. Not expressed during the earliest stages of vesicle formation (10.5 dpc). Expression begins coincidentally with the initiation of regional shape changes in the otic vesicle at 11.5 dpc and is restricted to the dorsolateral region. At 13.5 dpc, expression is limited to the inner edge of the semicircular canal epithelium, flanking the site of fusion, and this restricted expression continues at P1 (PubMed:11784868). At 14.5 dpc expression is observed in the primitive plexiform layer of the hippocampus. At P0, expression is observed in both the pyramidal and granule cell layers. Expression persistes in these cells in the adult hippocampus after their postnatal maturation. In addition, expression is also observed in the hilar mossy cells of the dentate gyrus (PubMed:15456880). At 7.5 dpc expression is ubiquitous, whereas at 9 dpc and 9.5 dpc, expression is restricted to the brain (PubMed:13129926). Induced by inflammatory stimuli (PubMed:20558821). Up- regulated by the anorexigenic signal leptin via the transcription factor cyclic AMP response element-binding protein (CREB). Suppressed by orexigenic signal glucocorticoid that mobilizes NR3C1 to inhibit NR4A3 expression by antagonizing the action of CREB (PubMed:23897430). The AF-1 domain mediates transcription activation. The N- terminal region (1-292) directly interacts with the C-terminal LBD (380-627): the interaction is potentiated by AF-1-mediated recruitment of NCOA2. Phosphorylated by PRKDC. Nr4a3 homozygous knockout mice are viable and normal in appearance; however, abnormal hyperactive and partial bidirectional circling behavior is observed by 3 weeks of age in 15% of these mice. The circling behavior is interspersed with noncircling periods of feeding, grooming, and sleep (PubMed:11784868). A small percentage of adult Nr4a3 homozygotes displayes brief freezing spells with tonic posturing that are exacerbated with handling (PubMed:15456880). The overall food consumption of Nr4a3 homozygous knockout mice is higher. Moreover, Nr4a3 homozygous mice lose more body weight upon fasting but clearly consumed more food during refeeding. By the end of the fasting period, Nr4a3 homozygous mice display signs of exhaustion (PubMed:23897430). Nr4a3 homozygous leads to embryonic lethality around 8.5 dpc (PubMed:13129926). Belongs to the nuclear hormone receptor family. NR4 subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding mesoderm formation DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated gastrulation axon guidance zinc ion binding pyruvate oxidation positive regulation of cardiac muscle hypertrophy positive regulation of glucose transport protein kinase binding hippocampus development intracellular receptor signaling pathway adult behavior animal organ regeneration positive regulation of mast cell cytokine production histone acetyltransferase binding glucocorticoid receptor binding cAMP response element binding common myeloid progenitor cell proliferation positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway inner ear morphogenesis response to hydrogen peroxide mast cell granule protein homodimerization activity negative regulation of apoptotic process mast cell degranulation steroid hormone mediated signaling pathway response to peptide hormone negative regulation of neuron apoptotic process sequence-specific DNA binding cellular response to leptin stimulus cellular respiration fat cell differentiation positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation metal ion binding platelet-derived growth factor receptor signaling pathway regulation of smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation semicircular canal morphogenesis positive regulation of epithelial cell proliferation neuromuscular process controlling balance vestibular reflex regulation of type B pancreatic cell proliferation cellular response to corticotropin-releasing hormone stimulus cellular response to catecholamine stimulus energy homeostasis positive regulation of monocyte aggregation negative regulation of oxidative stress-induced neuron death negative regulation of hydrogen peroxide-induced neuron death positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration positive regulation of leukocyte apoptotic process positive regulation of feeding behavior uc008suu.1 uc008suu.2 uc008suu.3 uc008suu.4 
ENSMUST00000030028.5 Erp44 ENSMUST00000030028.5 endoplasmic reticulum protein 44, transcript variant 1 (from RefSeq NM_029572.3) ENSMUST00000030028.1 ENSMUST00000030028.2 ENSMUST00000030028.3 ENSMUST00000030028.4 ERP44_MOUSE Kiaa0573 NM_029572 Q3TVI1 Q6A045 Q9D1Q6 Txndc4 uc008suy.1 uc008suy.2 uc008suy.3 Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum. Forms mixed disulfides with both ERO1A and ERO1B and cargo folding intermediates; the interactions with ERO1A and ERO1B result in their retention in the endoplasmic reticulum (By similarity). Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3 (PubMed:15652484). The strength of this interaction inversely correlates with calcium concentration (PubMed:15652484). Q9D1Q6; P11881: Itpr1; NbExp=5; IntAct=EBI-541567, EBI-541478; Endoplasmic reticulum lumen Widely expressed. Sequence=BAD32251.1; Type=Erroneous initiation; Evidence=; protein disulfide isomerase activity protein binding endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment protein folding response to unfolded protein glycoprotein metabolic process cell surface response to endoplasmic reticulum stress cell redox homeostasis uc008suy.1 uc008suy.2 uc008suy.3 
ENSMUST00000030029.10 Invs ENSMUST00000030029.10 inversin, transcript variant 7 (from RefSeq NR_185249.1) A2AM57 A2AM57_MOUSE ENSMUST00000030029.1 ENSMUST00000030029.2 ENSMUST00000030029.3 ENSMUST00000030029.4 ENSMUST00000030029.5 ENSMUST00000030029.6 ENSMUST00000030029.7 ENSMUST00000030029.8 ENSMUST00000030029.9 Invs NR_185249 uc008sva.1 uc008sva.2 uc008sva.3 uc008sva.4 negative regulation of canonical Wnt signaling pathway uc008sva.1 uc008sva.2 uc008sva.3 uc008sva.4 
ENSMUST00000030030.15 Tex10 ENSMUST00000030030.15 testis expressed gene 10, transcript variant 3 (from RefSeq NM_001355741.1) ENSMUST00000030030.1 ENSMUST00000030030.10 ENSMUST00000030030.11 ENSMUST00000030030.12 ENSMUST00000030030.13 ENSMUST00000030030.14 ENSMUST00000030030.2 ENSMUST00000030030.3 ENSMUST00000030030.4 ENSMUST00000030030.5 ENSMUST00000030030.6 ENSMUST00000030030.7 ENSMUST00000030030.8 ENSMUST00000030030.9 NM_001355741 Q3URQ0 TEX10_MOUSE uc008sve.1 uc008sve.2 uc008sve.3 Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148 (PubMed:22872859). Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles (By similarity). Nucleus, nucleolus Nucleus, nucleoplasm Cytoplasm Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. Belongs to the IPI1/TEX10 family. nucleus nucleoplasm nucleolus cytoplasm MLL1 complex Rix1 complex uc008sve.1 uc008sve.2 uc008sve.3 
ENSMUST00000030032.13 Tmeff1 ENSMUST00000030032.13 transmembrane protein with EGF-like and two follistatin-like domains 1, transcript variant 2 (from RefSeq NM_021436.4) A2AJN3 ENSMUST00000030032.1 ENSMUST00000030032.10 ENSMUST00000030032.11 ENSMUST00000030032.12 ENSMUST00000030032.2 ENSMUST00000030032.3 ENSMUST00000030032.4 ENSMUST00000030032.5 ENSMUST00000030032.6 ENSMUST00000030032.7 ENSMUST00000030032.8 ENSMUST00000030032.9 NM_021436 Q6PFE7 Q8BRP7 Q8C536 Q9JJS1 TEFF1_MOUSE uc008svk.1 uc008svk.2 uc008svk.3 May inhibit NODAL and BMP signaling during neural patterning. May interact with ST14. Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PFE7-1; Sequence=Displayed; Name=2; IsoId=Q6PFE7-2; Sequence=VSP_024960; Name=3; IsoId=Q6PFE7-3; Sequence=VSP_024960, VSP_024961; Expressed in brain, neurointermediate lobe, pars distalis, pancreas, ovary and testis. At 8.5 dpc, highly expressed in the first branchial arch, somites, splanchnic mesoderm and ventral foregut epithelium. At 9.5 dpc, highly expressed in motor neurons and superficial neurons from the neural tube, and in the dorsal part of diencephalon and mesencephalon. At 11.5 dpc and 12.5 dpc, expressed in limbs. At 15.5 dpc, highly expressed in brain and spinal cord. Belongs to the tomoregulin family. Sequence=CAB90827.1; Type=Erroneous initiation; Evidence=; basement membrane plasma membrane multicellular organism development neuromuscular junction development motor neuron axon guidance animal organ morphogenesis tissue development membrane integral component of membrane dendrite development receptor clustering uc008svk.1 uc008svk.2 uc008svk.3 
ENSMUST00000030033.5 Cavin4 ENSMUST00000030033.5 caveolae associated 4 (from RefSeq NM_026509.3) A2AMM0 B1PRL4 CAVN4_MOUSE ENSMUST00000030033.1 ENSMUST00000030033.2 ENSMUST00000030033.3 ENSMUST00000030033.4 Murc NM_026509 Q5FW67 Q9CV87 Q9D728 uc012ddz.1 uc012ddz.2 uc012ddz.3 Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation (PubMed:24567387). Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (PubMed:26497963). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105). Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Interacts with CAVIN1 (PubMed:19546242). Interacts with CAVIN2; this augments the transactivation of NPPA. Interacts with CAV3, ADRA1A, ADRA1B, MAPK1 and MAPK3 (By similarity). Cytoplasm, myofibril, sarcomere Cytoplasm Cytoplasm, cytosol Membrane, caveola Cell membrane, sarcolemma Cell membrane Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm (PubMed:18332105). Localizes in the caveolae in a caveolin-dependent manner (PubMed:19546242). Abundantly expressed in cardiac and skeletal muscle (at protein level). Weaker expression in aorta and lung. In heart, expressed in cardiomyocytes and vascular smooth muscle cells but not in other surrounding cells including vascular endothelial cells. Expression increases during development from embryo to adult. Up-regulated in response to cardiac hypertrophy. The coiled coil domain (residues 44-77) is essential for membrane-targeting in cardiomyocytes. Mice exhibit normal caveolar morphology and cardiac function under physiological conditions, whereas upon alpha-1 adrenergic receptor stimulation, show attenuation of cardiac hypertrophy accompanied by suppressed MAPK1/2 activation. Belongs to the CAVIN family. Sequence=AAH89601.1; Type=Erroneous initiation; Evidence=; Sequence=BAB26442.1; Type=Frameshift; Evidence=; GTPase activator activity cytoplasm cytosol plasma membrane caveola Rho protein signal transduction multicellular organism development muscle organ development regulation of gene expression membrane sarcomere Z disc cell differentiation regulation of Rho protein signal transduction sarcolemma positive regulation of GTPase activity positive regulation of transcription from RNA polymerase II promoter cardiac myofibril assembly uc012ddz.1 uc012ddz.2 uc012ddz.3 
ENSMUST00000030036.6 Brinp1 ENSMUST00000030036.6 bone morphogenic protein/retinoic acid inducible neural specific 1 (from RefSeq NM_019967.2) BRNP1_MOUSE Brinp Dbc1 Dbccr1 ENSMUST00000030036.1 ENSMUST00000030036.2 ENSMUST00000030036.3 ENSMUST00000030036.4 ENSMUST00000030036.5 Fam5a NM_019967 Q80ZL2 Q812F0 Q8C1C9 Q920P3 Q920P4 Q9QXL0 uc008thw.1 uc008thw.2 uc008thw.3 Plays a role in neurogenesis, brain development, and the functioning of GABAergic neurons (PubMed:24528488, PubMed:27042284, PubMed:29960053). May suppress cell cycle progression in postmitotic neurons by inhibiting G1/S transition (PubMed:15193423, PubMed:24528488, PubMed:20025061). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q920P3-1; Sequence=Displayed; Name=2; IsoId=Q920P3-2; Sequence=VSP_017024, VSP_017025; Expressed in brain (PubMed:15193423, PubMed:20025061, PubMed:29960053). Expressed in GABAergic neurons of the pre-frontal cortex (PubMed:29960053). Weakly expressed in embryonic stem (ES) cells and in ES-derived neural stem cells (NSCs) (PubMed:15193423, PubMed:20025061). Expressed from 9.5 dpc. Up-regulated upon differentiation into neuronal cells in the presence of retinoic acid and BDNF. Up-regulated upon differentiation into astroglial cells. Belongs to the BRINP family. behavioral fear response molecular_function cellular_component cytoplasm endoplasmic reticulum cell cycle cell cycle arrest short-term memory cell death dendrite social behavior exploration behavior maternal behavior neuronal cell body positive regulation of neuron differentiation negative regulation of cell cycle negative regulation of mitotic cell cycle negative regulation of neurogenesis cellular response to retinoic acid vocalization behavior uc008thw.1 uc008thw.2 uc008thw.3 
ENSMUST00000030039.13 Fmn2 ENSMUST00000030039.13 formin 2 (from RefSeq NM_019445.2) ENSMUST00000030039.1 ENSMUST00000030039.10 ENSMUST00000030039.11 ENSMUST00000030039.12 ENSMUST00000030039.2 ENSMUST00000030039.3 ENSMUST00000030039.4 ENSMUST00000030039.5 ENSMUST00000030039.6 ENSMUST00000030039.7 ENSMUST00000030039.8 ENSMUST00000030039.9 FMN2_MOUSE NM_019445 Q505D3 Q9JL04 uc007dtd.1 uc007dtd.2 uc007dtd.3 Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:18848445, PubMed:21620703). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:18848445, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:21983562). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (PubMed:12447394, PubMed:18848445, PubMed:19062278, PubMed:21620703). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (By similarity). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (By similarity). Protects cells against apoptosis by protecting CDKN1A against degradation (By similarity). Interacts with SPIRE1 (PubMed:21705804). Binds actin (PubMed:21705804). Interacts with CDKN1A (By similarity). Cytoplasm, cytoskeleton Cytoplasm, cytosol Cytoplasm, perinuclear region Nucleus Nucleus, nucleolus Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cell cortex Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Colocalizes with the actin cytoskeleton (PubMed:21705804). Recruited to the membranes via its interaction with SPIRE1 (PubMed:21705804). Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (PubMed:21620703). Accumulates in the nucleus following DNA damage (By similarity). Detected in brain and in oocytes (at protein level) (PubMed:12447394, PubMed:19062278). Expressed almost exclusively in the developing and mature central nervous system (PubMed:10781961). Detected in oocytes (PubMed:12447394, PubMed:19062278). Expression begins at embryonic day 9.5 in the developing spinal cord and brain structures and continues in neonatal and adult brain structures including the olfactory bulb, cortex, thalamus, hypothalamus, hippocampus and cerebellum. No visible phenotype in male mice, but female mice show reduced fertility and produce at most one to three pups per litter (PubMed:12447394). Female mice display defects in asymmetric spindle positioning, asymmetric cell division and polar body extrusion during oocyte meiosis (PubMed:12447394). During early pregnancy, females present normal numbers of implantation sites, but only very few normal-looking embryos (PubMed:12447394). Most of the embryos show developmental delays and gross morphological defects, leading to embryonic death (PubMed:12447394). Belongs to the formin homology family. Cappuccino subfamily. actin binding nucleus nucleolus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane spindle cytosol cytoskeleton actin filament plasma membrane microvillus cell cortex cellular response to DNA damage stimulus multicellular organism development microtubule binding protein transport actin cytoskeleton membrane vesicle-mediated transport meiotic chromosome movement towards spindle pole cytoplasmic vesicle membrane cytoplasmic vesicle polar body extrusion after meiotic divisions negative regulation of protein catabolic process negative regulation of apoptotic process actin nucleation intracellular transport perinuclear region of cytoplasm oogenesis actin filament bundle assembly establishment of meiotic spindle localization homologous chromosome movement towards spindle pole involved in homologous chromosome segregation formin-nucleated actin cable assembly cellular response to hypoxia positive regulation of double-strand break repair uc007dtd.1 uc007dtd.2 uc007dtd.3 
ENSMUST00000030041.5 Ambp ENSMUST00000030041.5 alpha 1 microglobulin/bikunin precursor (from RefSeq NM_007443.4) AMBP_MOUSE ENSMUST00000030041.1 ENSMUST00000030041.2 ENSMUST00000030041.3 ENSMUST00000030041.4 Itil NM_007443 Q07456 Q61294 Q925W1 Q9DBJ9 uc008tfp.1 uc008tfp.2 uc008tfp.3 uc008tfp.4 This gene encodes a fusion protein that undergoes proteolytic processing to generate two mature proteins: alpha-1-microglobulin (A1m) is a heme-binding plasma glycoprotein of the lipocalin superfamily of proteins that bind to hydrophobic molecules, whereas bikunin belongs to the superfamily of Kunitz-type protease inhibitors. The transgenic mice specifically lacking bikunin, but not A1m, exhibit female infertility and an increased sensitivity to lung metastasis. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021660.1, D28812.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## [Alpha-1-microglobulin]: Antioxidant and tissue repair protein with reductase, heme-binding and radical-scavenging activities. Removes and protects against harmful oxidants and repairs macromolecules in intravascular and extravascular spaces and in intracellular compartments. Intravascularly, plays a regulatory role in red cell homeostasis by preventing heme- and reactive oxygen species- induced cell damage. Binds and degrades free heme to protect fetal and adult red blood cells from hemolysis. Reduces extracellular methemoglobin, a Fe3+ (ferric) form of hemoglobin that cannot bind oxygen, back to the Fe2+ (ferrous) form deoxyhemoglobin, which has oxygen-carrying potential. Upon acute inflammation, inhibits oxidation of low-density lipoprotein particles by MPO and limits vascular damage. Extravascularly, protects from oxidation products formed on extracellular matrix structures and cell membranes. Catalyzes the reduction of carbonyl groups on oxidized collagen fibers and preserves cellular and extracellular matrix ultrastructures. Importantly, counteracts the oxidative damage at blood-placenta interface, preventing leakage of free fetal hemoglobin into the maternal circulation. Intracellularly, has a role in maintaining mitochondrial redox homeostasis. Bound to complex I of the respiratory chain of mitochondria, may scavenge free radicals and preserve mitochondrial ATP synthesis. Protects renal tubule epithelial cells from heme-induced oxidative damage to mitochondria. Reduces cytochrome c from Fe3+ (ferric) to the Fe2+ (ferrous) state through formation of superoxide anion radicals in the presence of ascorbate or NADH/NADPH electron donor cofactors, ascorbate being the preferred cofactor (By similarity). Has a chaperone role in facilitating the correct folding of bikunin in the endoplasmic reticulum compartment (PubMed:32092411). [Inter-alpha-trypsin inhibitor light chain]: Kunitz-type serine protease inhibitor and structural component of extracellular matrix with a role in extracellular space remodeling and cell adhesion. Among others, has antiprotease activity toward kallikrein, a protease involved in airway inflammation; inhibits GZMK/granzyme, a granule- stored serine protease involved in NK and T cell cytotoxic responses; and inhibits PLG/plasmin, a protease required for activation of matrix metalloproteinases. As part of I-alpha-I complex, provides for the heavy chains to be transferred from I-alpha-I complex to hyaluronan in the presence of TNFAIP6, in a dynamic process that releases free bikunin and remodels extracellular matrix proteoglycan structures. Free bikunin, but not its heavy chain-bound form, acts as a potent protease inhibitor in airway secretions (By similarity). Part of hyaluronan-rich extracellular matrix that surrounds oocyte during cumulus oophorus expansion, an indispensable process for proper ovulation (PubMed:11145954, PubMed:11243855). Also inhibits calcium oxalate crystallization (By similarity). [Trypstatin]: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases. [Alpha-1-microglobulin]: Monomer. Homodimer. In plasma, it occurs as a monomer or dimer and in covalently-linked complexes with immunoglobulin A (IgA), ALB/albumin and F2/prothrombin. Chromophore- bound alpha-1-microglobulin interacts with the constant region of immunoglobulin A. Chromophore-bound alpha-1-microglobulin interacts with ALB with molar ratio 2:1 and 1:1; this interaction does not prevent fatty acid binding to ALB. Interacts with F2/prothrombin (via N-terminus) with molar ratio 2:1 and 1:1; this interaction does not prevent the activation of prothrombin to thrombin. Interacts with NDUFAB1, a subunit of mitochondrial complex I (By similarity). Interacts with FN1 (By similarity). [Inter-alpha-trypsin inhibitor light chain]: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin, and pre-alpha-inhibitor (P-alpha- I) of ITIH3/HC3 and bikunin. Interacts with TNFAIP6 (via Link domain). [Trypstatin]: Monomer. Also occurs as a complex with tryptase in mast cells. [Alpha-1-microglobulin]: Secreted Endoplasmic reticulum Cytoplasm, cytosol Cell membrane ; Peripheral membrane protein Nucleus membrane ; Peripheral membrane protein Mitochondrion inner membrane ; Peripheral membrane protein Secreted, extracellular space, extracellular matrix Note=The cellular uptake occurs via a non-endocytotic pathway and allows for localization to various membrane structures. A specific binding to plasma membrane suggests the presence of a cell receptor, yet to be identified. Directly binds collagen fibers type I. [Inter-alpha-trypsin inhibitor light chain]: Secreted Expressed by the liver and secreted in plasma (at protein level). [Inter-alpha-trypsin inhibitor light chain]: The Kunitz domains 1 and 2 serve as protease inhibitor domains. The precursor is proteolytically processed into separately functioning proteins. [Alpha-1-microglobulin]: 3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1- microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross- links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'. [Inter-alpha-trypsin inhibitor light chain]: Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the C- terminal aspartate. [Inter-alpha-trypsin inhibitor light chain]: Proteolytically cleaved by PRSS3 at Kunitz domain 2. [Alpha-1-microglobulin]: Mutant mice has normal litter size. At 12 months of age they show significant increase in body weight, which is partly due to fat accumulation in the liver with a subsequent increase in liver mass (PubMed:32092411). They display an abnormal red blood cell morphology, similar to macrocytic anemia characterized by fewer, larger and heterogeneous red cells (PubMed:32092412). [Inter-alpha-trypsin inhibitor light chain]: Mice are born at the expected Mendelian rate. Mutant female mice show severe infertility due to impaired cumulus oophorus expansion upon gonadotropin surge. In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. serine-type endopeptidase inhibitor activity extracellular region extracellular space plasma membrane cell surface negative regulation of peptidase activity negative regulation of endopeptidase activity protein-chromophore linkage IgA binding heme binding protein catabolic process peptidase inhibitor activity protein homodimerization activity intracellular membrane-bounded organelle protein maturation uc008tfp.1 uc008tfp.2 uc008tfp.3 uc008tfp.4 
ENSMUST00000030042.3 Kif12 ENSMUST00000030042.3 kinesin family member 12, transcript variant 2 (from RefSeq NM_010616.3) ENSMUST00000030042.1 ENSMUST00000030042.2 KIF12_MOUSE NM_010616 O35061 Q9D2Z8 uc008tfq.1 uc008tfq.2 uc008tfq.3 uc008tfq.4 Cytoplasm, cytoskeleton Expressed in the liver. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding microtubule motor activity ATP binding cytoplasm microtubule organizing center cytoskeleton kinesin complex microtubule microtubule-based movement microtubule binding ATPase activity extracellular exosome uc008tfq.1 uc008tfq.2 uc008tfq.3 uc008tfq.4 
ENSMUST00000030044.3 Orm1 ENSMUST00000030044.3 orosomucoid 1 (from RefSeq NM_008768.2) A1AG1_MOUSE Agp1 ENSMUST00000030044.1 ENSMUST00000030044.2 NM_008768 Orm-1 Q60590 uc008tfx.1 uc008tfx.2 uc008tfx.3 uc008tfx.4 This gene encodes a member of the lipocalin family of proteins. The encoded protein is an abundant acute-phase protein that is synthesized by hepatocytes in response to cytokines during the acute phase response. The encoded protein may regulate inflammation and metabolism. This gene is present in a gene cluster on chromosome 4. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA494093.1, CA456410.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction. Secreted. Contains a beta-barrel that binds various ligands in its interior. Belongs to the calycin superfamily. Lipocalin family. regulation of immune system process extracellular region extracellular space acute-phase response uc008tfx.1 uc008tfx.2 uc008tfx.3 uc008tfx.4 
ENSMUST00000030047.3 Tnfsf8 ENSMUST00000030047.3 tumor necrosis factor (ligand) superfamily, member 8 (from RefSeq NM_009403.3) ENSMUST00000030047.1 ENSMUST00000030047.2 NM_009403 Q544U1 Q544U1_MOUSE Tnfsf8 Tnlg3a uc008thd.1 uc008thd.2 uc008thd.3 Belongs to the tumor necrosis factor family. cytokine activity tumor necrosis factor receptor binding extracellular space immune response signal transduction membrane integral component of membrane uc008thd.1 uc008thd.2 uc008thd.3 
ENSMUST00000030051.6 Txn1 ENSMUST00000030051.6 thioredoxin 1 (from RefSeq NM_011660.3) ENSMUST00000030051.1 ENSMUST00000030051.2 ENSMUST00000030051.3 ENSMUST00000030051.4 ENSMUST00000030051.5 NM_011660 P10639 Q52KC4 Q9D8R0 THIO_MOUSE Txn uc008syp.1 uc008syp.2 Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity). ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55). Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (By similarity). Nucleus Cytoplasm Secreted Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA). Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus. Secreted by a leaderless secretory pathway. In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins (By similarity). Belongs to the thioredoxin family. negative regulation of transcription from RNA polymerase II promoter protein binding extracellular region nucleus cytoplasm mitochondrion cytosol glycerol ether metabolic process response to radiation protein disulfide oxidoreductase activity peptide disulfide oxidoreductase activity enzyme binding axon dendrite positive regulation of peptidyl-serine phosphorylation neuronal cell body positive regulation of DNA binding cell redox homeostasis negative regulation of protein export from nucleus oxidation-reduction process negative regulation of hydrogen peroxide-induced cell death uc008syp.1 uc008syp.2 
ENSMUST00000030069.7 Ptgr1 ENSMUST00000030069.7 prostaglandin reductase 1 (from RefSeq NM_025968.3) ENSMUST00000030069.1 ENSMUST00000030069.2 ENSMUST00000030069.3 ENSMUST00000030069.4 ENSMUST00000030069.5 ENSMUST00000030069.6 Ltb4dh NM_025968 PTGR1_MOUSE Q3TKT6 Q91YR9 Q9CPS1 uc008szm.1 uc008szm.2 uc008szm.3 NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2- alpha (By similarity). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta- unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen- 2-one (By similarity). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity). Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15- oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584, ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133408; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50586; Evidence=; Reaction=13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15- oxoprostaglandin E2 + H(+) + NADPH; Xref=Rhea:RHEA:11912, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57402, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.48; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:11914; Evidence=; Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15- oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:79072, ChEBI:CHEBI:133411; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50594; Evidence=; Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374, ChEBI:CHEBI:133409; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50590; Evidence=; Reaction=leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:50608, ChEBI:CHEBI:15378, ChEBI:CHEBI:57461, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133309; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50609; Evidence= Reaction=20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy- leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:51208, ChEBI:CHEBI:15378, ChEBI:CHEBI:57460, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133346; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51209; Evidence=; Reaction=6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy- (6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH; Xref=Rhea:RHEA:51204, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:90723, ChEBI:CHEBI:133974; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51205; Evidence=; Reaction=(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH; Xref=Rhea:RHEA:51212, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133974, ChEBI:CHEBI:133975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51213; Evidence=; Reaction=an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:13737, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.74; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:13739; Evidence=; Reaction=hexanal + NADP(+) = (E)-hex-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:50776, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88528; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50778; Evidence=; Reaction=NADP(+) + octanal = (2E)-octenal + H(+) + NADPH; Xref=Rhea:RHEA:50780, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61748; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50782; Evidence=; Reaction=decanal + NADP(+) = (2E)-decenal + H(+) + NADPH; Xref=Rhea:RHEA:50612, ChEBI:CHEBI:15378, ChEBI:CHEBI:31457, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133455; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50614; Evidence=; Reaction=dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH; Xref=Rhea:RHEA:50784, ChEBI:CHEBI:15378, ChEBI:CHEBI:27836, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133741; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50786; Evidence=; Reaction=4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:64736, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58968, ChEBI:CHEBI:156112; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64738; Evidence=; Reaction=NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH; Xref=Rhea:RHEA:50788, ChEBI:CHEBI:15378, ChEBI:CHEBI:16472, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:145276; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50790; Evidence=; Reaction=NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH; Xref=Rhea:RHEA:50616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:77927, ChEBI:CHEBI:133457; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50618; Evidence=; Monomer or homodimer. Cytoplasm Belongs to the NADP-dependent oxidoreductase L4BD family. cytoplasm prostaglandin metabolic process oxidoreductase activity 2-alkenal reductase [NAD(P)] activity 13-prostaglandin reductase activity 15-oxoprostaglandin 13-oxidase activity oxidation-reduction process response to antineoplastic agent uc008szm.1 uc008szm.2 uc008szm.3 
ENSMUST00000030074.8 Ugcg ENSMUST00000030074.8 UDP-glucose ceramide glucosyltransferase (from RefSeq NM_011673.3) A2AN90 CEGT_MOUSE ENSMUST00000030074.1 ENSMUST00000030074.2 ENSMUST00000030074.3 ENSMUST00000030074.4 ENSMUST00000030074.5 ENSMUST00000030074.6 ENSMUST00000030074.7 NM_011673 O88693 Ugcg uc008szs.1 uc008szs.2 uc008szs.3 Participates in the initial step of the glucosylceramide- based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi. Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl- (1<->1')-N-acylsphing-4-enine) (PubMed:10430909, PubMed:16109770, PubMed:28373486). Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (PubMed:10430909). Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction (PubMed:10430909). They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions (PubMed:10430909). They are required for instance in the proper development and functioning of the nervous system (PubMed:16109770). As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway (PubMed:23554574). They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope (PubMed:17145749, PubMed:23748427). The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (PubMed:22851168). Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4- enine) using UDP-Xyl as xylose donor (PubMed:33361282). Reaction=an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D- glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP; Xref=Rhea:RHEA:12088, ChEBI:CHEBI:15378, ChEBI:CHEBI:22801, ChEBI:CHEBI:52639, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.80; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12089; Evidence=; Reaction=an N-acylsphing-4-enine + UDP-alpha-D-xylose = a beta-D- xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP; Xref=Rhea:RHEA:70243, ChEBI:CHEBI:15378, ChEBI:CHEBI:52639, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:189068; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70244; Evidence=; Reaction=N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP; Xref=Rhea:RHEA:70247, ChEBI:CHEBI:15378, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:77996, ChEBI:CHEBI:189081; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70248; Evidence=; Lipid metabolism; sphingolipid metabolism. Interacts with RTN1; regulates the ceramide glucosyltransferase activity of UGCG. Golgi apparatus membrane ; Multi-pass membrane protein Expressed early in preimplantation development, being already detected in eight-cell-stage embryos. The D1, D2, D3, (Q/R)XXRW motif is a critical part of the GCS active site, involved in catalysis and UDP-sugar binding. Embryonic lethal (PubMed:10430909). Homozygous knockout embryos initiate gastrulation with clear differentiation into embryonic germ layers, mesoderm, endoderm and ectoderm as well as the regional expression of critical genes (PubMed:10430909). However, a major apoptotic process leads to their resorption that starts at 7.5 dpc and is completed at 9.5 dpc (PubMed:10430909). Neural cell-specific conditional knockout does not affect early brain development but mice die between postnatal days 11 and 24 (PubMed:16109770). Dysfunction of cerebellum and peripheral nerves associated with some structural defects are observed (PubMed:16109770, PubMed:20544855). Peripheral nerves display increased surface area for both axon and myelin (PubMed:16109770). Purkinje cells undergo axonal degeneration associated with a disruption of myelin sheaths (PubMed:20544855). Forebrain neuron-specific conditional knockout leads to development of progressive obesity, hyperleptinemia, and glucose intolerance (PubMed:23554574). Epidermal-specific conditional knockout leads to a significant decrease of the total glucosylceramide content in the epidermis, a failure of the skin water barrier and a detachment of the stratum corneum (PubMed:17145749). Enterocyte-specific conditional knockout mice display deficient absorption of nutritional lipids (PubMed:22851168). Severe defects in intestinal epithelial differentiation also appear between postnatal days 5 and 7 but not before (PubMed:22851168). Hepatocyte-specific conditional knockout does not change basic liver functions with respect to sterol, glucose, and lipoprotein homeostasis (PubMed:20432257). Belongs to the glycosyltransferase 2 family. Golgi membrane Golgi apparatus protein lipidation lipid metabolic process sphingolipid metabolic process glucosylceramide biosynthetic process ceramide glucosyltransferase activity regulation of signal transduction membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups cell differentiation keratinocyte differentiation leptin-mediated signaling pathway neuron development establishment of skin barrier intestinal lipid absorption cornified envelope assembly uc008szs.1 uc008szs.2 uc008szs.3 
ENSMUST00000030076.12 Ptbp3 ENSMUST00000030076.12 polypyrimidine tract binding protein 3, transcript variant 2 (from RefSeq NM_178164.4) A2ANH0 A2ANH1 ENSMUST00000030076.1 ENSMUST00000030076.10 ENSMUST00000030076.11 ENSMUST00000030076.2 ENSMUST00000030076.3 ENSMUST00000030076.4 ENSMUST00000030076.5 ENSMUST00000030076.6 ENSMUST00000030076.7 ENSMUST00000030076.8 ENSMUST00000030076.9 NM_178164 PTBP3_MOUSE Q8BHD7 Q923C3 Rod1 uc008szx.1 uc008szx.2 uc008szx.3 RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes Fas exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U) (By similarity). Interacts with THBS4 (via the acidic amphipathic C-terminus). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BHD7-1; Sequence=Displayed; Name=2; IsoId=Q8BHD7-2; Sequence=VSP_010869; nucleic acid binding RNA binding nucleus mRNA processing RNA splicing cell differentiation negative regulation of RNA splicing erythrocyte maturation regulation of cell differentiation negative regulation of mRNA splicing, via spliceosome uc008szx.1 uc008szx.2 uc008szx.3 
ENSMUST00000030078.12 Hsdl2 ENSMUST00000030078.12 hydroxysteroid dehydrogenase like 2, transcript variant 1 (from RefSeq NM_024255.3) ENSMUST00000030078.1 ENSMUST00000030078.10 ENSMUST00000030078.11 ENSMUST00000030078.2 ENSMUST00000030078.3 ENSMUST00000030078.4 ENSMUST00000030078.5 ENSMUST00000030078.6 ENSMUST00000030078.7 ENSMUST00000030078.8 ENSMUST00000030078.9 HSDL2_MOUSE NM_024255 Q2TPA8 Q3ULY5 Q3UVZ3 Q8C3H3 Q99LV2 uc008szz.1 uc008szz.2 uc008szz.3 uc008szz.4 Has apparently no steroid dehydrogenase activity. Peroxisome Widely expressed. Up-regulated by cholesterol-rich food. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Sequence=BAC39563.1; Type=Frameshift; Evidence=; molecular_function mitochondrion peroxisome biological_process oxidoreductase activity oxidation-reduction process uc008szz.1 uc008szz.2 uc008szz.3 uc008szz.4 
ENSMUST00000030080.7 Snx30 ENSMUST00000030080.7 sorting nexin family member 30 (from RefSeq NM_172468.2) ENSMUST00000030080.1 ENSMUST00000030080.2 ENSMUST00000030080.3 ENSMUST00000030080.4 ENSMUST00000030080.5 ENSMUST00000030080.6 NM_172468 Q3UHE6 Q8CE50 SNX30_MOUSE Snx30 uc008tae.1 uc008tae.2 uc008tae.3 Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Together with SNX4, involved in autophagosome assembly. Heterodimer; heterodimerizes with SNX4. Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the sorting nexin family. cytoplasm protein transport phosphatidylinositol binding uc008tae.1 uc008tae.2 uc008tae.3 
ENSMUST00000030081.2 Slc46a2 ENSMUST00000030081.2 solute carrier family 46, member 2 (from RefSeq NM_021053.4) A2ANT4 ENSMUST00000030081.1 NM_021053 Q8CA03 Q9D3J2 Q9JLQ3 S46A2_MOUSE Slc46a2 Tscot uc008taf.1 uc008taf.2 uc008taf.3 uc008taf.4 Proton-coupled transporter that delivers pathogen-associated or danger-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes or tissue injury (PubMed:28539433, PubMed:34235268, PubMed:37116499). Has selectivity toward muropeptides that contain the amino acid diaminopimelic acid (DAP-type peptidoglycan muropeptides) including Tri-DAP and tracheal toxin (TCT), common in Gram-negative bacteria and Gram-positive bacilli. In the context of immune recognition of skin microbiota, shuttles bacterial muropeptides across the endolysosomal membranes into the cytosol for recognition by NOD1, triggering MYD88- dependent secretion of IL1A and neutrophil recruitment in a pyroptosis- type inflammatory process (PubMed:28539433, PubMed:37116499). To a lesser extent and redundantly, transports muramyl dipeptides derived from most bacterial proteoglycans, eliciting NOD2 receptor activation and downstream inflammatory responses (PubMed:28539433). Postulated to function as an importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages. Selectively imports cGAMPs derived from pathogenic bacteria such as 3'3'-cGAMP thus providing for differential immune recognition of pathogenic versus commensal bacteria. During tumorigenesis may transport extracellular tumor- derived 2'3'-cGAMP across the plasma membrane of M1-polarized macrophages to activate the anti-tumoral stimulator of interferon genes (STING) pathway (PubMed:34235268). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable). Reaction=n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro- N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso- diaminoheptanedioate-D-alanine(out) = n H(+)(in) + N-acetyl-beta-D- glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl- gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(in); Xref=Rhea:RHEA:76355, ChEBI:CHEBI:15378, ChEBI:CHEBI:195208; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76356; Evidence=; Reaction=n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso- diaminoheptanedioate(out) = n H(+)(in) + L-alanyl-gamma-D-glutamyl- meso-diaminoheptanedioate(in); Xref=Rhea:RHEA:64412, ChEBI:CHEBI:15378, ChEBI:CHEBI:61401; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64413; Evidence=; Reaction=n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in); Xref=Rhea:RHEA:76371, ChEBI:CHEBI:15378, ChEBI:CHEBI:155830; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76372; Evidence=; Reaction=2',3'-cGAMP(out) + n H(+)(out) = 2',3'-cGAMP(in) + n H(+)(in); Xref=Rhea:RHEA:76411, ChEBI:CHEBI:15378, ChEBI:CHEBI:143093; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76412; Evidence=; Reaction=3',3'-cGAMP(out) + n H(+)(out) = 3',3'-cGAMP(in) + n H(+)(in); Xref=Rhea:RHEA:76415, ChEBI:CHEBI:15378, ChEBI:CHEBI:71501; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76416; Evidence=; Down-regulated by the anti-inflammatory drug methotrexate. Endosome membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Localizes in acidic vesicles likely late endosomes and/or endolysosomes. Expressed on cortical epithelial cells in the thymus. Mainly expressed in the thymic cortex and is highly enriched in SCID thymus. Also expressed in lymph nodes, heart, fetal liver, brain, spleen, intestine and kidney, but not in adult liver, skin, skeletal muscle and lung. Expressed in skin epidermis. Highly expressed during fetal thymus development and decreases after day 16. Glycosylated. Mutant mice are resistant to psoriatic inflammation. Belongs to the major facilitator superfamily. SLC46A family. molecular_function plasma membrane integral component of plasma membrane cell surface membrane integral component of membrane transmembrane transporter activity T cell homeostasis regulation of T cell differentiation thymus development transmembrane transport negative regulation of T cell apoptotic process positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway uc008taf.1 uc008taf.2 uc008taf.3 uc008taf.4 
ENSMUST00000030090.4 Alad ENSMUST00000030090.4 aminolevulinate, delta-, dehydratase, transcript variant 1 (from RefSeq NM_008525.5) ENSMUST00000030090.1 ENSMUST00000030090.2 ENSMUST00000030090.3 HEM2_MOUSE Lv NM_008525 P10518 Q3THV6 uc008tfa.1 uc008tfa.2 uc008tfa.3 uc008tfa.4 Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). Reaction=2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen; Xref=Rhea:RHEA:24064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58126, ChEBI:CHEBI:356416; EC=4.2.1.24; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 8 zinc ions per octamer. Requires four zinc ions per octamer for full catalytic activity. Can bind up to 2 zinc ions per subunit. ; Can alternate between a fully active homooctamer and a low-activity homohexamer. A bound magnesium ion may promote the assembly of the fully active homooctamer. The magnesium-binding site is absent in the low-activity homohexamer. Inhibited by compounds that favor the hexameric state. Inhibited by divalent lead ions. The lead ions partially displace the zinc cofactor (By similarity). Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4. Homooctamer; active form. Homohexamer; low activity form (By similarity). Belongs to the ALAD family. response to hypoxia catalytic activity porphobilinogen synthase activity extracellular space cytosol porphyrin-containing compound biosynthetic process protoporphyrinogen IX biosynthetic process heme biosynthetic process response to oxidative stress response to nutrient metabolic process zinc ion binding response to herbicide response to toxic substance response to hormone response to organic substance response to inorganic substance response to metal ion response to iron ion response to zinc ion response to aluminum ion response to ionizing radiation response to vitamin B1 response to selenium ion response to lead ion response to organic cyclic compound response to activity lyase activity response to nutrient levels response to cobalt ion response to lipopolysaccharide tetrapyrrole biosynthetic process response to vitamin E response to vitamin response to drug identical protein binding response to amino acid response to ethanol response to arsenic-containing substance response to cadmium ion response to mercury ion metal ion binding protein homooligomerization response to glucocorticoid response to methylmercury response to platinum ion response to fatty acid cellular response to lead ion cellular response to interleukin-4 negative regulation of proteasomal protein catabolic process proteasome core complex binding uc008tfa.1 uc008tfa.2 uc008tfa.3 uc008tfa.4 
ENSMUST00000030091.10 Pole3 ENSMUST00000030091.10 polymerase (DNA directed), epsilon 3 (p17 subunit) (from RefSeq NM_021498.3) A0A0R4J091 A0A0R4J091_MOUSE ENSMUST00000030091.1 ENSMUST00000030091.2 ENSMUST00000030091.3 ENSMUST00000030091.4 ENSMUST00000030091.5 ENSMUST00000030091.6 ENSMUST00000030091.7 ENSMUST00000030091.8 ENSMUST00000030091.9 NM_021498 Pole3 uc008tfb.1 uc008tfb.2 uc008tfb.3 uc008tfb.4 Nucleus nucleus Ada2/Gcn5/Ada3 transcription activator complex epsilon DNA polymerase complex histone H3 acetylation protein heterodimerization activity uc008tfb.1 uc008tfb.2 uc008tfb.3 uc008tfb.4 
ENSMUST00000030103.9 Dmac1 ENSMUST00000030103.9 distal membrane arm assembly complex 1 (from RefSeq NM_025849.4) DMAC1_MOUSE Dmac1 ENSMUST00000030103.1 ENSMUST00000030103.2 ENSMUST00000030103.3 ENSMUST00000030103.4 ENSMUST00000030103.5 ENSMUST00000030103.6 ENSMUST00000030103.7 ENSMUST00000030103.8 NM_025849 Q9CQ00 Tmem261 uc008tjk.1 uc008tjk.2 uc008tjk.3 Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. Interacts with incompletely assembled mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Mitochondrion inner membrane ; Multi-pass membrane protein molecular_function mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I membrane integral component of membrane mitochondrial respiratory chain complex I assembly uc008tjk.1 uc008tjk.2 uc008tjk.3 
ENSMUST00000030110.15 Zdhhc21 ENSMUST00000030110.15 zinc finger, DHHC domain containing 21, transcript variant 2 (from RefSeq NR_149737.1) ENSMUST00000030110.1 ENSMUST00000030110.10 ENSMUST00000030110.11 ENSMUST00000030110.12 ENSMUST00000030110.13 ENSMUST00000030110.14 ENSMUST00000030110.2 ENSMUST00000030110.3 ENSMUST00000030110.4 ENSMUST00000030110.5 ENSMUST00000030110.6 ENSMUST00000030110.7 ENSMUST00000030110.8 ENSMUST00000030110.9 Gramp3 NR_149737 Q6EMK1 Q80XQ3 Q9D270 ZDH21_MOUSE Zdhhc21 uc008tkj.1 uc008tkj.2 uc008tkj.3 uc008tkj.4 Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:19956733, PubMed:26715683, PubMed:27653213). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity). Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation (PubMed:19956733). Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium (PubMed:27653213). Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction (PubMed:26715683). May also palmitoylate eNOS and LCK (PubMed:19956733). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Golgi apparatus membrane ; Multi-pass membrane protein Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Widely expressed (PubMed:26715683). Expressed in Henle's layer within the hair bulb and the hair shaft cuticle (at protein level) (PubMed:19956733). Expression is limited to the post- mitotic lineages of inner root sheath (IRS) and cuticle (PubMed:19956733). In the developing skin, expression is not be detected prior to hair follicle induction (13 dpc). Expression is initially detected in the inner root sheath (IRS) of developing vibrissae follicles at 16 dpc and later in the developing IRS of 18.5 dpc pelage follicles. The DHHC domain is required for palmitoyltransferase activity. Note=Defects in zdhhc21 are the cause of the depilated (dep) phenotype. It is a recessive phenotype characterized by variable hair loss, with thinner and shorter hairs remaining in a greasy coat which is due to a defect in the epidermis, rather than the dermis (PubMed:19956733). Depilated (dep) mutant mice are protected against endothelial dysfunction in systemic inflammatory response syndrome (PubMed:27653213). They are also tachycardic and hypotensive (PubMed:26715683). Belongs to the DHHC palmitoyltransferase family. hair follicle development endoplasmic reticulum Golgi apparatus plasma membrane protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity sebaceous gland development uc008tkj.1 uc008tkj.2 uc008tkj.3 uc008tkj.4 
ENSMUST00000030117.5 Smu1 ENSMUST00000030117.5 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) (from RefSeq NM_021535.4) ENSMUST00000030117.1 ENSMUST00000030117.2 ENSMUST00000030117.3 ENSMUST00000030117.4 NM_021535 Q3UKJ7 Q6PFR6 Q8BMY4 Q9D1I8 Q9JJ70 SMU1_MOUSE uc008shu.1 uc008shu.2 uc008shu.3 uc008shu.4 Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity). Component of the spliceosome B complex. Interacts with IK. Cytoplasm Nucleus Nucleus speckle Note=Colocalizes with SRSF1 in nuclear speckles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UKJ7-1; Sequence=Displayed; Name=2; IsoId=Q3UKJ7-2; Sequence=VSP_018593; At 10.5 dpc expressed in otic vesicle. The WD repeats assemble into a seven-bladed WD propeller. Belongs to the WD repeat SMU1 family. [Isoform 2]: Sequence=BAC25322.1; Type=Frameshift; Evidence=; regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome molecular_function nucleus spliceosomal complex cytoplasm mRNA processing RNA splicing nuclear speck U2-type precatalytic spliceosome uc008shu.1 uc008shu.2 uc008shu.3 uc008shu.4 
ENSMUST00000030119.10 Aptx ENSMUST00000030119.10 aprataxin, transcript variant 3 (from RefSeq NM_001025445.2) APTX_MOUSE ENSMUST00000030119.1 ENSMUST00000030119.2 ENSMUST00000030119.3 ENSMUST00000030119.4 ENSMUST00000030119.5 ENSMUST00000030119.6 ENSMUST00000030119.7 ENSMUST00000030119.8 ENSMUST00000030119.9 NM_001025445 Q7TQC5 Q8BPA7 Q8C2B5 Q8K3D1 Q9CQ59 uc008shp.1 uc008shp.2 uc008shp.3 uc008shp.4 DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241). Also able to hydrolyze adenosine 5'- monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). Reaction=a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)- DNA + H2O = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+); Xref=Rhea:RHEA:52128, Rhea:RHEA-COMP:13180, Rhea:RHEA- COMP:13181, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:136413, ChEBI:CHEBI:456215; EC=3.6.1.71; Evidence=; Reaction=a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'- deoxyribonucleotide-DNA + H2O = a 5'-end 5'-monophospho- ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+); Xref=Rhea:RHEA:52132, Rhea:RHEA-COMP:13182, Rhea:RHEA-COMP:13183, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:136414, ChEBI:CHEBI:136415, ChEBI:CHEBI:456215; EC=3.6.1.71; Evidence=; Reaction=a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+); Xref=Rhea:RHEA:52140, Rhea:RHEA-COMP:13186, Rhea:RHEA- COMP:13187, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58115, ChEBI:CHEBI:136419, ChEBI:CHEBI:136420; EC=3.6.1.72; Evidence=; Interacts with single-strand break repair proteins XRCC1, XRCC4, ADPRT/PARP1 and p53/TP53. Interacts with NCL. Interacts (via FHA-like domain) with MDC1 (phosphorylated). Nucleus, nucleoplasm Nucleus, nucleolus Note=Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage. Colocalizes with MDC1 at sites of DNA double-strand breaks. Interaction with NCL is required for nucleolar localization (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q7TQC5-1; Sequence=Displayed; Name=2; IsoId=Q7TQC5-2; Sequence=VSP_010542; Name=3; IsoId=Q7TQC5-3; Sequence=VSP_010543; Name=4; IsoId=Q7TQC5-4; Sequence=VSP_010543, VSP_010544; Widely expressed. Expressed in heart, liver, kidney, spleen, lung, muscle, brain stem, spinal cord, cerebellum and brain. The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide. The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4. The HIT domain is required for enzymatic activity. The C2H2-type zinc finger mediates DNA-binding. Sequence=AAP86334.1; Type=Erroneous initiation; Evidence=; single strand break repair chromatin nuclear chromatin nucleic acid binding DNA binding chromatin binding damaged DNA binding double-stranded DNA binding single-stranded DNA binding double-stranded RNA binding catalytic activity nucleus nucleoplasm nucleolus DNA ligation DNA repair double-strand break repair cellular response to DNA damage stimulus phosphoglycolate phosphatase activity dephosphorylation hydrolase activity mismatched DNA binding regulation of protein stability DNA 5'-adenosine monophosphate hydrolase activity response to hydrogen peroxide polynucleotide 3'-phosphatase activity metal ion binding protein N-terminus binding phosphoprotein binding nucleic acid phosphodiester bond hydrolysis polynucleotide 3' dephosphorylation single-strand break-containing DNA binding uc008shp.1 uc008shp.2 uc008shp.3 uc008shp.4 
ENSMUST00000030121.13 B4galt1 ENSMUST00000030121.13 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, transcript variant 3 (from RefSeq NR_165793.2) B4galt1 ENSMUST00000030121.1 ENSMUST00000030121.10 ENSMUST00000030121.11 ENSMUST00000030121.12 ENSMUST00000030121.2 ENSMUST00000030121.3 ENSMUST00000030121.4 ENSMUST00000030121.5 ENSMUST00000030121.6 ENSMUST00000030121.7 ENSMUST00000030121.8 ENSMUST00000030121.9 NR_165793 Q3U478 Q3U478_MOUSE uc008shw.1 uc008shw.2 uc008shw.3 uc008shw.4 This gene encodes two distinct enzyme isoforms, a long membrane-bound form and a short soluble form. These alternate isoforms are thought to be produced through alternative nested transcription initiation and different in-frame start codon usage. These enzymes catalyze the transfer of galactose to acceptor sugars, such as N-acetylglucosamine and glucose. The long form of this enzyme is localized to the trans-Golgi membrane and is involved in glycoconjugate biosynthesis. The short form functions in lactose biosynthesis though formation of a heterodimer with alpha-lactalbumin. [provided by RefSeq, Nov 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7652917.1280493.1, SRR7345562.3588082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END## Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 7 family. Golgi trans cisterna beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity N-acetyllactosamine synthase activity lactose synthase activity Golgi apparatus carbohydrate metabolic process protein N-linked glycosylation oligosaccharide biosynthetic process external side of plasma membrane membrane integral component of membrane basolateral plasma membrane transferase activity transferase activity, transferring glycosyl groups desmosome manganese ion binding brush border membrane UDP-galactosyltransferase activity protein homooligomerization uc008shw.1 uc008shw.2 uc008shw.3 uc008shw.4 
ENSMUST00000030122.5 Spink4 ENSMUST00000030122.5 serine peptidase inhibitor, Kazal type 4 (from RefSeq NM_011463.2) ENSMUST00000030122.1 ENSMUST00000030122.2 ENSMUST00000030122.3 ENSMUST00000030122.4 ISK4_MOUSE Mpgc60 NM_011463 O35679 Q149Z4 uc008shy.1 uc008shy.2 uc008shy.3 Secreted Expressed in the intestinal tract. serine-type endopeptidase inhibitor activity extracellular region negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc008shy.1 uc008shy.2 uc008shy.3 
ENSMUST00000030124.4 Tal2 ENSMUST00000030124.4 T cell acute lymphocytic leukemia 2 (from RefSeq NM_009317.4) ENSMUST00000030124.1 ENSMUST00000030124.2 ENSMUST00000030124.3 NM_009317 Q62282 TAL2_MOUSE uc008sxg.1 uc008sxg.2 uc008sxg.3 RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding nucleus regulation of transcription from RNA polymerase II promoter post-embryonic development thalamus development midbrain development multicellular organism growth protein dimerization activity uc008sxg.1 uc008sxg.2 uc008sxg.3 
ENSMUST00000030125.5 Bag1 ENSMUST00000030125.5 BCL2-associated athanogene 1, transcript variant 1 (from RefSeq NM_009736.3) Bag1 ENSMUST00000030125.1 ENSMUST00000030125.2 ENSMUST00000030125.3 ENSMUST00000030125.4 F6TCF9 F6TCF9_MOUSE NM_009736 uc008shz.1 uc008shz.2 uc008shz.3 uc008shz.4 uc008shz.5 The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to Bcl2 protein and is referred to as Bcl2-associated athanogene. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008]. chaperone binding uc008shz.1 uc008shz.2 uc008shz.3 uc008shz.4 uc008shz.5 
ENSMUST00000030127.13 Tmem38b ENSMUST00000030127.13 transmembrane protein 38B (from RefSeq NM_028053.2) A2AQG4 D4Ertd89e ENSMUST00000030127.1 ENSMUST00000030127.10 ENSMUST00000030127.11 ENSMUST00000030127.12 ENSMUST00000030127.2 ENSMUST00000030127.3 ENSMUST00000030127.4 ENSMUST00000030127.5 ENSMUST00000030127.6 ENSMUST00000030127.7 ENSMUST00000030127.8 ENSMUST00000030127.9 Mg33b NM_028053 Q3U6M4 Q3UBM6 Q3UWS8 Q9DAV9 TM38B_MOUSE uc008sxh.1 uc008sxh.2 uc008sxh.3 uc008sxh.4 Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2). Endoplasmic reticulum membrane ; Multi-pass membrane protein Widely expressed. Mice are neonatal lethal. Mice lacking Tmem38a and Tmem38b show a weak heartbeat at E9.5 followed by loss of cardiomyocyte viability and embryonic lethality around 10.5 dpc. Belongs to the TMEM38 family. Sequence=CAM21468.1; Type=Erroneous gene model prediction; Evidence=; ossification cation channel activity potassium channel activity endoplasmic reticulum endoplasmic reticulum membrane ion transport potassium ion transport endoplasmic reticulum organization phospholipid biosynthetic process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion release of sequestered calcium ion into cytosol by sarcoplasmic reticulum monovalent inorganic cation transport membrane integral component of membrane bone mineralization lung alveolus development release of sequestered calcium ion into cytosol bone development lung epithelial cell differentiation secretion by lung epithelial cell involved in lung growth extracellular matrix constituent secretion cellular response to caffeine potassium ion transmembrane transport calcium ion transport from endoplasmic reticulum to cytosol uc008sxh.1 uc008sxh.2 uc008sxh.3 uc008sxh.4 
ENSMUST00000030128.6 Chmp5 ENSMUST00000030128.6 charged multivesicular body protein 5 (from RefSeq NM_029814.1) CHMP5_MOUSE ENSMUST00000030128.1 ENSMUST00000030128.2 ENSMUST00000030128.3 ENSMUST00000030128.4 ENSMUST00000030128.5 NM_029814 Q3UI64 Q9D7S9 Snf7dc2 uc008sib.1 uc008sib.2 uc008sib.3 Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity). Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with VTA1. Interacts with CHMP2A. Interacts with VTA1; the interaction involves soluble CHMP5 (By similarity). Interacts with NOD2 (By similarity). Interacts with BROX (By similarity). Cytoplasm, cytosol Endosome membrane ; Peripheral membrane protein Midbody Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Flemming body. ISGylated. Isgylation inhibits its interaction with VTA1 (By similarity). Belongs to the SNF7 family. regulation of receptor recycling nucleus cytoplasm endosome cytosol nucleus organization vacuolar transport lysosome organization mitotic metaphase plate congression endosome to lysosome transport endosome membrane regulation of centrosome duplication protein transport membrane viral budding multivesicular body-lysosome fusion cellular response to lipopolysaccharide cellular response to muramyl dipeptide multivesicular body sorting pathway regulation of mitotic spindle assembly uc008sib.1 uc008sib.2 uc008sib.3 
ENSMUST00000030134.9 Rad23b ENSMUST00000030134.9 RAD23 homolog B, nucleotide excision repair protein (from RefSeq NM_009011.4) ENSMUST00000030134.1 ENSMUST00000030134.2 ENSMUST00000030134.3 ENSMUST00000030134.4 ENSMUST00000030134.5 ENSMUST00000030134.6 ENSMUST00000030134.7 ENSMUST00000030134.8 Mhr23b NM_009011 P54728 Q3TUA4 RD23B_MOUSE uc012dej.1 uc012dej.2 uc012dej.3 Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with Cetn2 appears to stabilize Xpc. May protect Xpc from proteasomal degradation (By similarity). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the Xpc:Rad23b dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. Xpc:Rad23b contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. Xpc:Rad23bB induces a bend in DNA upon binding. Xpc:Rad23b stimulates the activity of DNA glycosylases Tdg and Smug1 (By similarity). Component of the XPC complex composed of XPC, RAD23B and CETN2. Interacts with NGLY1 and PSMC1. Interacts with ATXN3 (By similarity). Interacts with AMFR. Interacts with VCP; the interaction is indirect and mediated by NGLY1. Nucleus Cytoplasm Impaired embryonic development with a 90 % rate of intrauterine or neonatal death. Surviving animals display a variety of abnormalities, including retarded growth, facial dysmorphology and male sterility. The effect on NER competence is reported conflictingly: According PubMed:11809813 no change in NER activity is found and according PubMed:15336624 a reduced NER activity is seen. Embryonic lethal with Rad23a and Rad23b double deficiency. Double deficient cells show reduced cell survival upopn UV radiation and reduced steady-state level of Xpc indicating a reduced NER capacity. Belongs to the RAD23 family. proteasome complex nucleotide-excision repair, DNA damage recognition RNA polymerase II core promoter proximal region sequence-specific DNA binding damaged DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol DNA repair nucleotide-excision repair cellular response to DNA damage stimulus spermatogenesis polyubiquitin binding regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process transcription regulatory region DNA binding embryonic organ development proteasome binding XPC complex cellular response to interleukin-7 uc012dej.1 uc012dej.2 uc012dej.3 
ENSMUST00000030136.13 Aqp7 ENSMUST00000030136.13 aquaporin 7, transcript variant 2 (from RefSeq NM_007473.4) AQP 7 Aqp7 ENSMUST00000030136.1 ENSMUST00000030136.10 ENSMUST00000030136.11 ENSMUST00000030136.12 ENSMUST00000030136.2 ENSMUST00000030136.3 ENSMUST00000030136.4 ENSMUST00000030136.5 ENSMUST00000030136.6 ENSMUST00000030136.7 ENSMUST00000030136.8 ENSMUST00000030136.9 NM_007473 Q5DX24 Q5DX24_MOUSE uc008sig.1 uc008sig.2 uc008sig.3 Membrane ; Multi- pass membrane protein Belongs to the MIP/aquaporin (TC 1.A.8) family. channel activity porin activity membrane integral component of membrane pore complex transmembrane transport uc008sig.1 uc008sig.2 uc008sig.3 
ENSMUST00000030138.9 Nol6 ENSMUST00000030138.9 nucleolar protein family 6 (RNA-associated) (from RefSeq NM_139236.4) ENSMUST00000030138.1 ENSMUST00000030138.2 ENSMUST00000030138.3 ENSMUST00000030138.4 ENSMUST00000030138.5 ENSMUST00000030138.6 ENSMUST00000030138.7 ENSMUST00000030138.8 NM_139236 NOL6_MOUSE Q3TL75 Q3U1P8 Q6PAN8 Q8C6V4 Q8R5K3 Q8R5K4 Q8VCG0 Q8WTY7 uc008sii.1 uc008sii.2 uc008sii.3 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with RRP7A; required for NOL6 localization to nucleolus. Nucleus, nucleolus Chromosome Note=Localizes to condensed chromosomes in mitosis. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha, Long; IsoId=Q8R5K4-1; Sequence=Displayed; Name=2; Synonyms=Beta, Short; IsoId=Q8R5K4-2; Sequence=VSP_013533, VSP_013534; Ubiquitously expressed. Belongs to the NRAP family. Sequence=AAH19981.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH21856.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAL74401.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAL74402.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; condensed nuclear chromosome RNA binding nucleus chromosome nucleolus mitochondrion rRNA processing tRNA export from nucleus small-subunit processome CURI complex UTP-C complex uc008sii.1 uc008sii.2 uc008sii.3 
ENSMUST00000030140.3 Elp1 ENSMUST00000030140.3 elongator complex protein 1 (from RefSeq NM_026079.3) ELP1_MOUSE ENSMUST00000030140.1 ENSMUST00000030140.2 Ikap Ikbkap NM_026079 Q3UHY6 Q7TQH1 Q7TT37 Q8C6B3 Q8CBI3 Q8CH82 Q8VHU5 Q8VHV9 Q9CT81 uc012del.1 uc012del.2 Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:23717213). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:22854966). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity). tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Homodimer; dimerization promotes ELP1 stability and elongator complex formation. Component of the elongator complex which consists of ELP1, ELP2, ELP3, ELP4, ELP5 and ELP6. Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Q7TT37; P23242: Gja1; NbExp=3; IntAct=EBI-8418161, EBI-298630; Cytoplasm cleus In the testis, expression is restricted to germ cells during spermatogenesis with no expression detected in somatic cells such as Sertoli cells or Leydig cells (at protein level) (PubMed:23717213). In the ovary, expressed in oocytes of primary, secondary and antral follicles (at protein level) (PubMed:31827135). Widely expressed in adult tissues with highest levels in brain and also expressed at all embryonic stages (PubMed:11747609). During spermatogenesis, expressed in the testis in all male germ cell stages except elongated spermatids (at protein level) (PubMed:23717213). Highly expressed in fully-grown germinal vesicle oocytes and modest expression throughout the preimplantation stage with a slight down-regulation at the 2-cell stage (PubMed:31827135). In the embryo, expressed at embryonic days 7, 11, 15 and 17 with the highest expression at embryonic day 11 (PubMed:11747609). Phosphorylated. Conditional knockout in male germ cells results in defects in wobble uridine tRNA modification and defects in synapsis and meiotic recombination which result in increased apoptosis and complete arrest of gametogenesis, leading to male infertility (PubMed:23717213). Conditional knockout in female germ cells results in female subfertility with reduced litter size although ovaries are morphologically and histologically indistinguishable from those of controls (PubMed:31827135). Oocytes show aneuploidy, reduced alpha- tubulin acetylation and are unable to complete meiosis with defects in meiotic spindle organization, chromosome alignment and kinetochore function (PubMed:31827135). Embryos derived from Elp1-deficient oocytes exhibit digyny, progressive delays in preimplantation development and severe degeneration before reaching the blastocyst stage (PubMed:31827135). Belongs to the ELP1/IKA1 family. The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification. Sequence=AAL36025.1; Type=Frameshift; Evidence=; Sequence=AAO15309.1; Type=Frameshift; Evidence=; RNA polymerase II core binding tRNA wobble uridine modification protein kinase activity protein binding ATP binding nucleus nucleolus cytoplasm cytosol regulation of transcription from RNA polymerase II promoter I-kappaB phosphorylation transcription elongation factor complex phosphorylase kinase regulator activity positive regulation of cell migration Elongator holoenzyme complex regulation of protein kinase activity uc012del.1 uc012del.2 
ENSMUST00000030143.13 Ubap2 ENSMUST00000030143.13 ubiquitin-associated protein 2, transcript variant 7 (from RefSeq NR_185031.1) ENSMUST00000030143.1 ENSMUST00000030143.10 ENSMUST00000030143.11 ENSMUST00000030143.12 ENSMUST00000030143.2 ENSMUST00000030143.3 ENSMUST00000030143.4 ENSMUST00000030143.5 ENSMUST00000030143.6 ENSMUST00000030143.7 ENSMUST00000030143.8 ENSMUST00000030143.9 Lig1 NR_185031 Q812D6 Q91VX2 Q99K40 UBAP2_MOUSE Ubap2 uc290lwr.1 uc290lwr.2 Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage. May promote the degradation of ANXA2. May interact with ANXA2. Nucleus Chromosome Cytoplasm Note=Associates with nuclear chromatin. cytoplasm uc290lwr.1 uc290lwr.2 
ENSMUST00000030145.9 Dcaf12 ENSMUST00000030145.9 DDB1 and CUL4 associated factor 12 (from RefSeq NM_026893.3) DCA12_MOUSE Dcaf12 ENSMUST00000030145.1 ENSMUST00000030145.2 ENSMUST00000030145.3 ENSMUST00000030145.4 ENSMUST00000030145.5 ENSMUST00000030145.6 ENSMUST00000030145.7 ENSMUST00000030145.8 Kiaa1892 NM_026893 Q69Z77 Q8BGZ3 Q8BN60 Q8C1Y4 Q9DB95 Wdr40a uc008sil.1 uc008sil.2 uc008sil.3 uc008sil.4 Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:34065512). The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation. Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy (By similarity). Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins such as MOV10, leading to their ubiquitination and degradation. Controls the protein level of MOV10 during spermatogenesis and in T cells, especially after their activation (PubMed:34065512). Protein modification; protein ubiquitination. Component of the DCX(DCAF12) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1, DCAF12 and RBX1. Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Knockout mice are born at expected Mendelian ratios and manifest no apparent physical abnormalities. Mutants have testes that produce fewer mature sperms, an altered percentage of CD4(+) T-cells and natural killer (NK) cells as well as increased splenocyte apoptosis after T cell activation. Belongs to the WD repeat DCAF12 family. Sequence=BAC39908.1; Type=Frameshift; Evidence=; Sequence=BAD32567.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton biological_process protein ubiquitination Cul4-RING E3 ubiquitin ligase complex uc008sil.1 uc008sil.2 uc008sil.3 uc008sil.4 
ENSMUST00000030152.13 Spmip6 ENSMUST00000030152.13 sperm microtubule inner protein 6, transcript variant 4 (from RefSeq NR_045549.2) C9orf24 Cbe1 ENSMUST00000030152.1 ENSMUST00000030152.10 ENSMUST00000030152.11 ENSMUST00000030152.12 ENSMUST00000030152.2 ENSMUST00000030152.3 ENSMUST00000030152.4 ENSMUST00000030152.5 ENSMUST00000030152.6 ENSMUST00000030152.7 ENSMUST00000030152.8 ENSMUST00000030152.9 NR_045549 Q0GC36 Q2MH31 Q9D1B3 SMIP6_MOUSE SPMIP6 Smrp1 uc008six.1 uc008six.2 May participate in intramanchette transport and midpiece formation of the sperm tail (PubMed:31504408). May play a potential role in somatic cell proliferation (PubMed:31504408). Interacts with alpha-tubulin. Cytoplasm, cytoskeleton Nucleus Cytoplasm Mitochondrion Cell projection, cilium, flagellum Note=During spermatid elongation (step 10), localizes along the length of the manchette and later during the elongation process only at the distal ends of spermatid manchette (step 12). In late elongated spermatids (step 16), in the final steps of spermiogenesis, localization is restricted to the midpiece of the flagellum (PubMed:18163442, PubMed:31504408). Localizes at the contractile ring in dividing cells (PubMed:31504408). Predominantly perinuclear in bronchial epithelial cells but also detected in the nucleus in some primary epithelial cells and in a number of cell lines (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Cbe1-long-ORF1; IsoId=Q2MH31-1; Sequence=Displayed; Name=2; Synonyms=Cbe1-long-ORF2; IsoId=Q2MH31-4; Sequence=VSP_027173; Name=3; Synonyms=Cbe1-ORF1; IsoId=Q2MH31-2; Sequence=VSP_027172; Name=4; Synonyms=Cbe1-ORF2; IsoId=Q2MH31-3; Sequence=VSP_027172, VSP_027173; [Isoform 1]: Testis-specific, expressed exclusively in germ cells (at protein level). [Isoform 2]: Testis-specific. [Isoform 3]: Expressed in both lung and testis. [Isoform 4]: Expressed in both lung and testis. During male germ cell development, expression of isoform 1 begins at day 21, increases after day 30 and continues to increase in the adult. Expressed in elongating spermatids from steps 9- 12 (at protein level). Expression in the lung increases at 16 dpc. Up-regulated during cilia assembly in IMCD3 cells. Deficient mice are viable and have normal fertility. Belongs to the SPMIP6 family. manchette nucleus cytoplasm cytoskeleton spermatogenesis cell differentiation cellular macromolecular complex assembly alpha-tubulin binding perinuclear region of cytoplasm uc008six.1 uc008six.2 
ENSMUST00000030154.7 Nudt2 ENSMUST00000030154.7 nudix hydrolase 2 (from RefSeq NM_025539.2) AP4A_MOUSE Apah1 ENSMUST00000030154.1 ENSMUST00000030154.2 ENSMUST00000030154.3 ENSMUST00000030154.4 ENSMUST00000030154.5 ENSMUST00000030154.6 NM_025539 P56380 Q9D2U6 Q9D6V2 uc008sis.1 uc008sis.2 uc008sis.3 Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''- P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (By similarity). Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (PubMed:32432673). Reaction=H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = GMP + GTP + 2 H(+); Xref=Rhea:RHEA:22484, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:57553, ChEBI:CHEBI:58115; EC=3.6.1.17; Evidence=; Reaction=a 5'-end CoA-ribonucleoside in mRNA + H2O = (R)-4'- phosphopantetheine + a 5'-end phospho-adenosine-phospho- ribonucleoside in mRNA + 2 H(+); Xref=Rhea:RHEA:67592, Rhea:RHEA- COMP:15719, Rhea:RHEA-COMP:17276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:61723, ChEBI:CHEBI:144051, ChEBI:CHEBI:172371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67593; Evidence=; Reaction=a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+); Xref=Rhea:RHEA:67588, Rhea:RHEA-COMP:15719, Rhea:RHEA-COMP:17275, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58210, ChEBI:CHEBI:144051, ChEBI:CHEBI:172372; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67589; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Divalent metal ions. ; Belongs to the Nudix hydrolase family. nucleotide binding bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity GTP binding mitochondrion apoptotic process bis(5'-nucleosyl)-tetraphosphatase activity hydrolase activity uc008sis.1 uc008sis.2 uc008sis.3 
ENSMUST00000030158.11 Dctn3 ENSMUST00000030158.11 dynactin 3, transcript variant 1 (from RefSeq NM_016890.4) DCTN3_MOUSE Dctn3 ENSMUST00000030158.1 ENSMUST00000030158.10 ENSMUST00000030158.2 ENSMUST00000030158.3 ENSMUST00000030158.4 ENSMUST00000030158.5 ENSMUST00000030158.6 ENSMUST00000030158.7 ENSMUST00000030158.8 ENSMUST00000030158.9 NM_016890 Q9CR43 Q9D039 Q9Z0Y1 uc008sji.1 uc008sji.2 uc008sji.3 uc008sji.4 Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis (By similarity). Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Cleavage furrow Midbody Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells. Belongs to the dynactin subunit 3 family. chromosome, centromeric region kinetochore condensed chromosome kinetochore molecular_function chromosome nucleolus cytoplasm centrosome microtubule organizing center spindle cytosol cytoskeleton dynactin complex microtubule microtubule associated complex microtubule-based process cell cycle midbody cleavage furrow perinuclear region of cytoplasm cell division cytoskeleton-dependent cytokinesis uc008sji.1 uc008sji.2 uc008sji.3 uc008sji.4 
ENSMUST00000030163.12 Spata31g1 ENSMUST00000030163.12 SPATA31 subfamily G member 1 (from RefSeq NM_026088.3) A2AG32 ENSMUST00000030163.1 ENSMUST00000030163.10 ENSMUST00000030163.11 ENSMUST00000030163.2 ENSMUST00000030163.3 ENSMUST00000030163.4 ENSMUST00000030163.5 ENSMUST00000030163.6 ENSMUST00000030163.7 ENSMUST00000030163.8 ENSMUST00000030163.9 NM_026088 Q3V0E1 Q9CVP8 Q9CVW7 S31G1_MOUSE uc008soq.1 uc008soq.2 uc008soq.3 uc008soq.4 Dispensable for normal development and fertility. Expressed in kidney and testis (PubMed:36871790). Expressed at lower levels in stomach, intestine, epididymis and ovary (PubMed:36871790). Expressed at very low levels in heart and spleen (PubMed:36871790). No visible phenotype (PubMed:36871790). No effect on testis size, testis-to-body weight ratio, germ cell development or spermiogenesis (PubMed:36871790). No effect on sperm morphology, count or motility (PubMed:36871790). No effect on levels of germ cell apoptosis, chromosome H1t histone association or acrosome biogenesis (PubMed:36871790). molecular_function cellular_component biological_process uc008soq.1 uc008soq.2 uc008soq.3 uc008soq.4 
ENSMUST00000030164.8 Vcp ENSMUST00000030164.8 valosin containing protein (from RefSeq NM_009503.4) ENSMUST00000030164.1 ENSMUST00000030164.2 ENSMUST00000030164.3 ENSMUST00000030164.4 ENSMUST00000030164.5 ENSMUST00000030164.6 ENSMUST00000030164.7 NM_009503 Q01853 Q3TFH9 Q3TIM2 Q3TXN9 Q6PI18 Q8BSR6 Q8CEG4 TERA_MOUSE Vcp uc008sor.1 uc008sor.2 uc008sor.3 uc008sor.4 Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4- UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum- associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (By similarity). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Involved in clearance process by mediating G3BP1 extraction from stress granules (By similarity). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (By similarity). Involved in interstrand cross- link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (PubMed:33590678). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (By similarity). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy. Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI. May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation. May more particularly play a role in caveolins sorting in cells. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.6; Evidence=; Homohexamer. Forms a ring-shaped particle of 12.5 nm diameter, that displays 6-fold radial symmetry. Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Binds to a heterodimer of NPLOC4 and UFD1, binding to this heterodimer inhibits Golgi-membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Part of a ternary complex containing NPLOC4, UFD1 and VCP. Interacts with NSFL1C-like protein p37; the complex has membrane fusion activity and is required for Golgi and endoplasmic reticulum biogenesis. Interacts with RNF103. Interacts with TRIM13 and TRIM21. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of the endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Interacts directly with AMFR/gp78 (via its VIM). Interacts with RHBDD1 (via C-terminal domain). Interacts with SPRTN; leading to recruitment to stalled replication forks. Interacts with SELENOS and SYVN1, as well as with DERL1 (via SHP-box motif), DERL2 and DERL3; which probably transfer misfolded proteins from the ER to VCP. Interacts with SVIP. Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Part of a complex composed of STUB1/CHIP, VCP/p97, CHRNA3, and UBXN2A that modulates the ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of CHRNA3 (By similarity). Within the complex UBXN2A acts as a scaffold protein required for the interaction of CHRNA3 with VCP/p97, this interaction also inhibits CHRNA3 ubiquitination by STUB1/CHIP and subsequently ERAD (By similarity). Interacts with UBXN2A (via UBX domain); the interaction is required for the interaction of CHRNA3 in the STUB1-VCP-UBXN2A complex (By similarity). Directly interacts with UBXN4 and RNF19A. Interacts with CASR. Interacts with UBE4B and YOD1. Interacts with clathrin. Interacts with RNF103. Interacts with TRIM13 and TRIM21. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of the endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Interacts directly with AMFR/gp78 (via its VIM). Interacts with WASHC5. Interacts with UBOX5. Interacts (via N- terminus) with UBXN7, UBXN8, and probably several other UBX domain- containing proteins (via UBX domains); the interactions are mutually exclusive with VIM-dependent interactions such as those with AMFR and SELENOS. Forms a complex with UBQLN1 and UBXN4 (By similarity). Interacts (via the PIM motif) with RNF31 (via the PUB domain) (By similarity). Interacts with RIGI and RNF125; interaction takes place when RIGI is ubiquitinated via'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (By similarity). Interacts with BAG6 (By similarity). Interacts with UBXN10 (By similarity). Interacts with UBXN6; the interaction with UBXN6 is direct and competitive with UFD1 (By similarity). Forms a ternary complex with CAV1 and UBXN6. Interacts with PLAA, UBXN6 and YOD1; may form a complex involved in macroautophagy (By similarity). Interacts with ANKZF1 (By similarity). Interacts with ubiquitin-binding protein FAF1 (By similarity). Interacts with ZFAND2B (via VIM motif); the interaction is direct (PubMed:24160817, PubMed:26337389). Interacts with ZFAND1 (via its ubiquitin-like region); this interaction occurs in an arsenite- dependent manner (By similarity). Interacts with CCDC47 (PubMed:25009997). Interacts with LMBR1L and UBAC2 (PubMed:31073040). Interacts with ATXN3 (By similarity). Interacts with TEX264; bridging VCP to covalent DNA-protein cross-links (DPCs) (By similarity). Q01853; Q9R049: Amfr; NbExp=4; IntAct=EBI-80597, EBI-3648125; Q01853; Q80UU1: Ankzf1; NbExp=2; IntAct=EBI-80597, EBI-9510971; Q01853; Q9JI78: Ngly1; NbExp=9; IntAct=EBI-80597, EBI-3648128; Q01853; P70362: Ufd1; NbExp=9; IntAct=EBI-80597, EBI-7961331; Q01853; Q01853: Vcp; NbExp=3; IntAct=EBI-80597, EBI-80597; Q01853; P36037: DOA1; Xeno; NbExp=2; IntAct=EBI-80597, EBI-6017; Q01853; Q9ES54: Nploc4; Xeno; NbExp=11; IntAct=EBI-80597, EBI-1993990; Q01853; O35987: Nsfl1c; Xeno; NbExp=8; IntAct=EBI-80597, EBI-1993760; Q01853; Q9BQE4: SELENOS; Xeno; NbExp=4; IntAct=EBI-80597, EBI-398970; Cytoplasm, cytosol Endoplasmic reticulum Nucleus Cytoplasm, Stress granule Nucleus Note=Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78. Following DNA double-strand breaks, recruited to the sites of damage. Recruited to stalled replication forks via interaction with SPRTN. Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. Colocalizes with TIA1, ZFAND1 and G3BP1 in cytoplasmic stress granules (SGs) in response to arsenite-induced stress treatment (By similarity). Expressed in the prefrontal cortex (at protein level). The N-terminal domain shows evolutionary conservation with that of PEX1, and is able to bind phospholipids with a preference for phosphatidylinositol mono- and bisphosphates. The PIM (PUB-interaction motif) motif mediates interaction with the PUB domain of RNF31. Phosphorylated by tyrosine kinases in response to T-cell antigen receptor activation. Phosphorylated in mitotic cells. ISGylated. Methylation at Lys-315 catalyzed by VCPKMT is increased in the presence of ASPSCR1. Lys-315 methylation may decrease ATPase activity (By similarity). Belongs to the AAA ATPase family. nucleotide binding proteasome complex receptor binding protein binding ATP binding nucleus nucleoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum membrane lipid particle cytosol DNA repair double-strand break repair ubiquitin-dependent protein catabolic process NADH metabolic process ER to Golgi vesicle-mediated transport autophagy activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus lipid binding cytoplasmic stress granule proteasomal protein catabolic process positive regulation of mitochondrial membrane potential macroautophagy protein ubiquitination hydrolase activity ATPase activity protein N-linked glycosylation via asparagine viral genome replication protein phosphatase binding protein domain specific binding translesion synthesis ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol positive regulation of protein complex assembly polyubiquitin binding ubiquitin protein ligase binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process endosome to lysosome transport via multivesicular body sorting pathway macromolecular complex VCP-NPL4-UFD1 AAA ATPase complex protein hexamerization cellular response to heat stress granule disassembly deubiquitinase activator activity site of double-strand break K48-linked polyubiquitin binding ERAD pathway Derlin-1 retrotranslocation complex MHC class I protein binding identical protein binding proteasome-mediated ubiquitin-dependent protein catabolic process myelin sheath intracellular membrane-bounded organelle ADP binding ubiquitin-like protein ligase binding macromolecular complex binding synapse positive regulation of protein catabolic process ATP metabolic process perinuclear region of cytoplasm regulation of synapse organization mitotic spindle disassembly protein homooligomerization aggresome assembly ER-associated misfolded protein catabolic process flavin adenine dinucleotide catabolic process positive regulation of canonical Wnt signaling pathway autophagosome maturation glutamatergic synapse positive regulation of protein K63-linked deubiquitination positive regulation of Lys63-specific deubiquitinase activity regulation of aerobic respiration cellular response to arsenite ion positive regulation of oxidative phosphorylation BAT3 complex binding ATPase complex ubiquitin-specific protease binding VCP-NSFL1C complex positive regulation of ubiquitin-specific protease activity positive regulation of ATP biosynthetic process uc008sor.1 uc008sor.2 uc008sor.3 uc008sor.4 
ENSMUST00000030165.5 Fancg ENSMUST00000030165.5 Fanconi anemia, complementation group G, transcript variant 17 (from RefSeq NR_189676.1) A2AG34 ENSMUST00000030165.1 ENSMUST00000030165.2 ENSMUST00000030165.3 ENSMUST00000030165.4 FANCG_MOUSE NR_189676 Q9EQR6 uc008sos.1 uc008sos.2 uc008sos.3 uc008sos.4 DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene (By similarity). Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. In complex with FANCF, FANCA and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins. The complex with FANCC and FANCG may also include EIF2AK2 and HSP70. Nucleus Highest expression levels in spleen, thymus and testis. ovarian follicle development nucleus nucleolus mitochondrion cytosol plasma membrane DNA repair cellular response to DNA damage stimulus mitochondrion organization spermatid development response to radiation interstrand cross-link repair Fanconi anaemia nuclear complex uc008sos.1 uc008sos.2 uc008sos.3 uc008sos.4 
ENSMUST00000030169.15 Stoml2 ENSMUST00000030169.15 stomatin (Epb7.2)-like 2, transcript variant 3 (from RefSeq NM_023231.3) ENSMUST00000030169.1 ENSMUST00000030169.10 ENSMUST00000030169.11 ENSMUST00000030169.12 ENSMUST00000030169.13 ENSMUST00000030169.14 ENSMUST00000030169.2 ENSMUST00000030169.3 ENSMUST00000030169.4 ENSMUST00000030169.5 ENSMUST00000030169.6 ENSMUST00000030169.7 ENSMUST00000030169.8 ENSMUST00000030169.9 NM_023231 Q99JB2 Q9DCG8 STML2_MOUSE Slp2 uc008soy.1 uc008soy.2 uc008soy.3 Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T- cell receptor signaling complex and its regulation. Forms homooligomers (By similarity). Interacts with MFN2; may form heterooligomers (By similarity). Interacts with PHB1 and PHB2; recruits them to cardiolipin-enriched mitochondrial membranes and stabilizes them (By similarity). Interacts with CACNA2D2. Cell membrane ; Peripheral membrane protein Mitochondrion Mitochondrion inner membrane ; Lipid-anchor Mitochondrion intermembrane space Membrane raft Cytoplasm, cytoskeleton Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain. Also associates with the actin cytoskeleton and membrane rafts in activated T-cells. A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells. Embryonic lethal at the preimplantation stage. T- cell-specific conditional knockout does not alter the normal development of those cells but decreases their responses to stimulation through the T-cell receptor. Belongs to the band 7/mec-2 family. immunological synapse cytoplasm mitochondrion mitochondrial inner membrane mitochondrial intermembrane space cytoskeleton plasma membrane mitochondrial calcium ion transport cellular calcium ion homeostasis mitochondrion organization COP9 signalosome lipid binding lipid localization positive regulation of mitochondrial membrane potential actin cytoskeleton membrane extrinsic component of plasma membrane interleukin-2 production mitochondrial protein processing CD4-positive, alpha-beta T cell activation T cell receptor complex mitochondrial ATP synthesis coupled proton transport membrane raft T cell receptor signaling pathway GTPase binding protein oligomerization positive regulation of mitochondrial DNA replication positive regulation of cardiolipin metabolic process cardiolipin binding stress-induced mitochondrial fusion mitochondrion localization uc008soy.1 uc008soy.2 uc008soy.3 
ENSMUST00000030170.15 Unc13a ENSMUST00000030170.15 unc-13 homolog A (from RefSeq NM_001029873.2) E9QKH9 ENSMUST00000030170.1 ENSMUST00000030170.10 ENSMUST00000030170.11 ENSMUST00000030170.12 ENSMUST00000030170.13 ENSMUST00000030170.14 ENSMUST00000030170.2 ENSMUST00000030170.3 ENSMUST00000030170.4 ENSMUST00000030170.5 ENSMUST00000030170.6 ENSMUST00000030170.7 ENSMUST00000030170.8 ENSMUST00000030170.9 NM_001029873 Q3UHG2 Q4KUS2 UN13A_MOUSE Unc13a uc033jgc.1 uc033jgc.2 uc033jgc.3 Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA- mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (PubMed:23229896). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (By similarity). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with the N-termini of STX1A and/or STX1B1 and DOC2A. Interacts with BSN. Interacts with RIMS1 which recruits UNC13A to the active zone. Forms homodimers via its first C2 domain. Also interacts via this domain with the zinc finger domain of RIMS2. Part of a complex consisting of ERC2, RIMS1 and UNC13A. Also part of a complex consisting of UNC13A, RIMS2 and RAB3A (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (PubMed:19996097). Cytoplasm Cell membrane ; Peripheral membrane protein Presynaptic cell membrane ; Peripheral membrane protein Presynaptic active zone Note=Translocated to the plasma membrane in response to phorbol ester binding. The C2 domains are not involved in calcium-dependent phospholipid binding. The C-terminal region containing both MHD domains and the third C2 domain is required for synaptic vesicle priming activity. Mice display normal synapse formation but abnormal synaptic vesicle maturation and die shortly after birth. Heterozygotes exhibit impaired insulin secretion and abnormal glucose tolerance. SNARE binding positive regulation of neurotransmitter secretion calcium ion binding protein binding calmodulin binding phospholipid binding cytoplasm Golgi-associated vesicle plasma membrane exocytosis chemical synaptic transmission neurotransmitter secretion neuromuscular junction development regulation of synaptic vesicle priming membrane synaptic vesicle exocytosis synaptic vesicle docking synaptic vesicle priming synaptic vesicle maturation syntaxin-1 binding protein domain specific binding syntaxin binding diacylglycerol binding cell junction cell differentiation axon spectrin binding synaptic vesicle membrane neuromuscular junction positive regulation of synaptic plasticity macromolecular complex synaptic transmission, glutamatergic intracellular signal transduction presynaptic membrane identical protein binding protein homodimerization activity neuron projection terminal bouton calyx of Held synapse metal ion binding protein heterodimerization activity protein N-terminus binding regulation of short-term neuronal synaptic plasticity presynaptic active zone beta-amyloid metabolic process excitatory synapse long-term synaptic potentiation innervation dense core granule priming synaptic membrane presynapse presynaptic active zone cytoplasmic component glutamatergic synapse presynaptic dense core vesicle exocytosis positive regulation of glutamate receptor signaling pathway regulation of amyloid precursor protein catabolic process positive regulation of dendrite extension dense core granule docking uc033jgc.1 uc033jgc.2 uc033jgc.3 
ENSMUST00000030180.7 Sit1 ENSMUST00000030180.7 suppression inducing transmembrane adaptor 1 (from RefSeq NM_019436.3) ENSMUST00000030180.1 ENSMUST00000030180.2 ENSMUST00000030180.3 ENSMUST00000030180.4 ENSMUST00000030180.5 ENSMUST00000030180.6 NM_019436 Q8C503 Q9WUU5 SIT1_MOUSE Sit uc008spw.1 uc008spw.2 uc008spw.3 uc008spw.4 Negatively regulates T-cell antigen receptor (TCR)-mediated signaling. Involved in positive selection of T-cells. Homodimer; disulfide-linked. When phosphorylated, interacts with PTPN11/SHP2, GRB2 and CSK (By similarity). Cell membrane ; Single-pass type III membrane protein Expressed in thymus and spleen, with highest levels in immature thymocytes (at protein level). Phosphorylated on tyrosines upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK. Mice are viable and fertile, with normal growth and no obvious abnormalities. They show normal B-cell development and peripheral B-cell functions, but have mildly altered thymic development probably due to enhanced TCR signaling. This results in a greater susceptibility to autoimmune diseases. adaptive immune response immune system process plasma membrane signal transduction membrane integral component of membrane kinase binding T cell homeostasis regulation of T cell activation uc008spw.1 uc008spw.2 uc008spw.3 uc008spw.4 
ENSMUST00000030181.12 Ccdc107 ENSMUST00000030181.12 coiled-coil domain containing 107 (from RefSeq NM_001037913.2) A2AIN4 CC107_MOUSE ENSMUST00000030181.1 ENSMUST00000030181.10 ENSMUST00000030181.11 ENSMUST00000030181.2 ENSMUST00000030181.3 ENSMUST00000030181.4 ENSMUST00000030181.5 ENSMUST00000030181.6 ENSMUST00000030181.7 ENSMUST00000030181.8 ENSMUST00000030181.9 NM_001037913 Q9CTB6 Q9DCC3 uc008spy.1 uc008spy.2 uc008spy.3 uc008spy.4 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DCC3-1; Sequence=Displayed; Name=2; IsoId=Q9DCC3-2; Sequence=VSP_024134; Sequence=BAB23140.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008spy.1 uc008spy.2 uc008spy.3 uc008spy.4 
ENSMUST00000030183.10 Car9 ENSMUST00000030183.10 carbonic anhydrase 9 (from RefSeq NM_139305.2) CAH9_MOUSE Ca9 ENSMUST00000030183.1 ENSMUST00000030183.2 ENSMUST00000030183.3 ENSMUST00000030183.4 ENSMUST00000030183.5 ENSMUST00000030183.6 ENSMUST00000030183.7 ENSMUST00000030183.8 ENSMUST00000030183.9 NM_139305 Q8K1G1 Q8VDE4 Q8VHB5 uc008sqa.1 uc008sqa.2 uc008sqa.3 Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10749; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:10750; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Inhibited by acetazolamide. Forms oligomers linked by disulfide bonds. Nucleus Nucleus, nucleolus Cell membrane ; Single-pass type I membrane protein Cell projection, microvillus membrane ; Single-pass type I membrane protein Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VHB5-1; Sequence=Displayed; Name=2; IsoId=Q8VHB5-2; Sequence=VSP_007409, VSP_007410; Asn-325 bears high-mannose type glycan structures. Belongs to the alpha-carbonic anhydrase family. response to hypoxia morphogenesis of an epithelium carbonate dehydratase activity plasma membrane zinc ion binding membrane integral component of membrane basolateral plasma membrane lyase activity microvillus membrane response to testosterone response to drug cell projection metal ion binding secretion uc008sqa.1 uc008sqa.2 uc008sqa.3 
ENSMUST00000030187.14 Tln1 ENSMUST00000030187.14 talin 1 (from RefSeq NM_011602.5) A2AIM8 ENSMUST00000030187.1 ENSMUST00000030187.10 ENSMUST00000030187.11 ENSMUST00000030187.12 ENSMUST00000030187.13 ENSMUST00000030187.2 ENSMUST00000030187.3 ENSMUST00000030187.4 ENSMUST00000030187.5 ENSMUST00000030187.6 ENSMUST00000030187.7 ENSMUST00000030187.8 ENSMUST00000030187.9 NM_011602 P26039 Q8VEF0 TLN1_MOUSE Tln uc008sqe.1 uc008sqe.2 uc008sqe.3 uc008sqe.4 High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. Part of a complex composed of THSD1, PTK2/FAK1, TLN1 and VCL (By similarity). Interacts with THSD1; this promotes interaction with PTK2/FAK1 and VCL (By similarity). Interacts with NRAP and LAYN (By similarity). Interacts with SYNM (By similarity). Interacts with ITGB1; the interaction is prevented by competitive binding of ITGB1BP1 (By similarity). Binds with high affinity to VCL and with low affinity to integrins (PubMed:23389036, PubMed:20610383, PubMed:15642262, PubMed:15272303). Interacts with APBB1IP; this inhibits VCL binding (PubMed:23389036). Interacts with PTK2/FAK1 (PubMed:7622520). Interacts with PIP5K1C (PubMed:15623515). Interacts with F-actin (PubMed:20610383). Interacts with SVEP1 (PubMed:36792666). P26039; Q8R5A3: Apbb1ip; NbExp=8; IntAct=EBI-1039593, EBI-7450496; P26039; Q64727: Vcl; NbExp=2; IntAct=EBI-1039593, EBI-432047; P26039; P05556: ITGB1; Xeno; NbExp=2; IntAct=EBI-1039593, EBI-703066; P26039; P05106: ITGB3; Xeno; NbExp=7; IntAct=EBI-1039593, EBI-702847; P26039; P12003: VCL; Xeno; NbExp=5; IntAct=EBI-1039593, EBI-1039563; Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Cell surface Cell junction, focal adhesion Note=Colocalizes with LAYN at the membrane ruffles (By similarity). Localized preferentially in focal adhesions than fibrillar adhesions. Consists of an N-terminal FERM domain linked via a short unstructured region to a large flexible C-terminal rod which contains 13 amphipathic helical bundles (R1-R13). The rod begins with a five- helix bundle (R1) followed by three four-helix bundles (R2-R4). These are followed by a series of eight five-helix bundles (R5-R7 and R9-R13) in which the N- and C-termini are positioned at opposite ends of the bundle, creating a linear chain. The four-helix bundle R8 does not disrupt the chain because it is inserted into a loop in the R7 five- helix bundle. The uneven distribution of four- and five-helix bundles creates two distinctly different zones: a compact N-terminal region sensitive to stretch and a linear C-terminal region that is optimal for force transmission. ruffle phosphatidylserine binding actin binding integrin binding structural constituent of cytoskeleton protein binding cytoplasm cytoskeleton plasma membrane focal adhesion cytoskeletal anchoring at plasma membrane cell-substrate junction assembly cell adhesion integrin-mediated signaling pathway cell surface membrane vinculin binding cell junction LIM domain binding cortical actin cytoskeleton organization ruffle membrane integrin activation phosphatidylinositol binding cell projection actin filament binding uc008sqe.1 uc008sqe.2 uc008sqe.3 uc008sqe.4 
ENSMUST00000030189.14 Gba2 ENSMUST00000030189.14 glucosidase beta 2, transcript variant 1 (from RefSeq NM_172692.4) ENSMUST00000030189.1 ENSMUST00000030189.10 ENSMUST00000030189.11 ENSMUST00000030189.12 ENSMUST00000030189.13 ENSMUST00000030189.2 ENSMUST00000030189.3 ENSMUST00000030189.4 ENSMUST00000030189.5 ENSMUST00000030189.6 ENSMUST00000030189.7 ENSMUST00000030189.8 ENSMUST00000030189.9 GBA2_MOUSE Gba2 Kiaa1605 NM_172692 Q69ZF3 Q6PGM3 Q8BTN9 uc008sqi.1 uc008sqi.2 uc008sqi.3 uc008sqi.4 Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl- (1<->1')-N-acylsphing-4-enine) to free glucose and ceramides (such as N-acylsphing-4-enine) (PubMed:17080196, PubMed:23250757). GlcCers are membrane glycosphingolipids that have a wide intracellular distribution (PubMed:23250757). They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties (PubMed:25803043). Also involved in the transglucosylation of cholesterol, transferring glucose from GlcCer, thereby modifying its water solubility and biological properties (PubMed:26724485, PubMed:32144204). Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-3- beta-D-glucoside to ceramide (such as N-acylsphing-4-enine) (PubMed:26724485, PubMed:32144204). May play a role in the metabolism of bile acids (PubMed:17080196). Able to hydrolyze bile acid 3-O- glucosides as well as to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity (PubMed:17080196). Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D- galactosyl-(1<->1')-N-acylsphing-4-enine), as well as galactosyl transfer between GalCers and cholesterol in vitro with lower activity compared with their activity against GlcCers (PubMed:32144204). Reaction=a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N- acylsphing-4-enine + D-glucose; Xref=Rhea:RHEA:13269, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:22801, ChEBI:CHEBI:52639; EC=3.2.1.45; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13270; Evidence=; Reaction=a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose; Xref=Rhea:RHEA:14297, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377, ChEBI:CHEBI:18390, ChEBI:CHEBI:52639; EC=3.2.1.46; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14298; Evidence=; Reaction=beta-D-glucosyl-(1->3)-O-lithocholate + H2O = D-glucose + lithocholate; Xref=Rhea:RHEA:58344, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:29744, ChEBI:CHEBI:142611; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58345; Evidence=; Reaction=beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose; Xref=Rhea:RHEA:58340, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:36234, ChEBI:CHEBI:142610; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58341; Evidence=; Reaction=a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate = a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+); Xref=Rhea:RHEA:59104, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9528, ChEBI:CHEBI:15378, ChEBI:CHEBI:36234, ChEBI:CHEBI:57525, ChEBI:CHEBI:57683, ChEBI:CHEBI:142610; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59105; Evidence=; Reaction=chenodeoxycholate + octyl beta-D-glucose = beta-D-glucosyl- (1->3)-O-chenodeoxycholate + octan-1-ol; Xref=Rhea:RHEA:59108, ChEBI:CHEBI:16188, ChEBI:CHEBI:36234, ChEBI:CHEBI:41128, ChEBI:CHEBI:142610; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59109; Evidence=; Reaction=cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D- glucose; Xref=Rhea:RHEA:11956, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11957; Evidence=; Reaction=a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside; Xref=Rhea:RHEA:58264, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:22801, ChEBI:CHEBI:52639; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58265; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:58266; Evidence=; Reaction=beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)- sphing-4-enine; Xref=Rhea:RHEA:58324, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:77996, ChEBI:CHEBI:139140; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58325; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:58326; Evidence=; Reaction=a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D- galactoside; Xref=Rhea:RHEA:70235, ChEBI:CHEBI:16113, ChEBI:CHEBI:18390, ChEBI:CHEBI:52639, ChEBI:CHEBI:189066; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70236; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70237; Evidence=; Reaction=1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine; Xref=Rhea:RHEA:70255, ChEBI:CHEBI:16113, ChEBI:CHEBI:72956, ChEBI:CHEBI:73432, ChEBI:CHEBI:189066; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70256; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70257; Evidence=; Enzymatic activity is dependent on membrane association and requires the presence of lipids (PubMed:23250757). Inhibited by N-(adamantanemethyloxypentyl)-deoxynojirimycin/AMP-DNM (PubMed:26724485). Inhibited by its product sphingosine/N-acylsphing-4- enine in a feedback loop (PubMed:28258214). Also inhibited by other non-acetylated sphingoid bases and their derivatives but not by sphingosine-1-phosphate and complex sphingolipids (PubMed:28258214). pH dependence: Optimum pH is between 6.0 and 7.0. ; Lipid metabolism; sphingolipid metabolism. Steroid metabolism; cholesterol metabolism. Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Localization to the plasma membrane and alternative topologies have also been reported. Widely expressed at low level (PubMed:17080196). Highly expressed in testis and brain (PubMed:17080196). Ubiquitously expressed in the brain (at protein level) (PubMed:23250757). Expressed by Sertoli cells (at protein level) (PubMed:17080196). Homozygous knockout mice display an accumulation of glucosylceramides in testis, brain and liver (PubMed:17080196). The accumulation of glucosylceramides in Sertoli cells alters sperm shape and males exhibit impaired fertility (PubMed:17080196). Despite the bile acid glucosidase and transferase activities measured in vitro, bile acid metabolism is normal in knockout mice (PubMed:17080196). No obvious neurological symptoms, organomegaly or lifespan alteration are observed (PubMed:17080196). Cholesterol metabolism and protein glycosylation are also normal in these mice (PubMed:17080196). Belongs to the non-lysosomal glucosylceramidase family. Sequence=BAD32491.1; Type=Erroneous initiation; Evidence=; Golgi membrane catalytic activity glucosylceramidase activity hydrolase activity, hydrolyzing O-glycosyl compounds endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol lipid metabolic process sphingolipid metabolic process glucosylceramide catabolic process central nervous system development metabolic process steroid metabolic process cholesterol metabolic process beta-glucosidase activity membrane integral component of membrane glycoside catabolic process transferase activity transferase activity, transferring glycosyl groups hydrolase activity hydrolase activity, acting on glycosyl bonds extrinsic component of membrane central nervous system neuron development lipid glycosylation regulation of actin filament polymerization regulation of microtubule polymerization extrinsic component of endoplasmic reticulum membrane glucosyltransferase activity steryl-beta-glucosidase activity extrinsic component of Golgi membrane regulation of membrane lipid distribution bile acid metabolic process uc008sqi.1 uc008sqi.2 uc008sqi.3 uc008sqi.4 
ENSMUST00000030191.15 Npr2 ENSMUST00000030191.15 natriuretic peptide receptor 2, transcript variant 1 (from RefSeq NM_173788.4) ANPRB_MOUSE B1AWI8 ENSMUST00000030191.1 ENSMUST00000030191.10 ENSMUST00000030191.11 ENSMUST00000030191.12 ENSMUST00000030191.13 ENSMUST00000030191.14 ENSMUST00000030191.2 ENSMUST00000030191.3 ENSMUST00000030191.4 ENSMUST00000030191.5 ENSMUST00000030191.6 ENSMUST00000030191.7 ENSMUST00000030191.8 ENSMUST00000030191.9 NM_173788 Q6VVW3 Q6VVW4 Q6VVW5 Q8CGA9 uc008sqm.1 uc008sqm.2 uc008sqm.3 Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2; Evidence=; Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=GC-B1; IsoId=Q6VVW5-1; Sequence=Displayed; Name=2; Synonyms=GC-B2; IsoId=Q6VVW5-2; Sequence=VSP_013583; Name=3; Synonyms=GC-B3; IsoId=Q6VVW5-3; Sequence=VSP_013584, VSP_013585; Widely expressed. Expressed in the columnar proliferating and prehypertrophic chondrocyte layers of the tibia. Phosphorylated. Phosphorylation of the protein kinase-like domain is required for full activation by CNP. Glycosylated. Mice mainly display dwarfism associated with impairment of endochondral ossification, reduced growth of longitudinal vertebra and limb-bone. Self-clasping and priapism that could be due to neuronal disorder are detected. The development of the female reproductive organ is affected. [Isoform 2]: Binds ligand, but no cyclase activation. [Isoform 3]: Fail to bind the ligand. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding ossification peptide receptor activity guanylate cyclase activity protein kinase activity ATP binding GTP binding plasma membrane integral component of plasma membrane cGMP biosynthetic process protein phosphorylation signal transduction receptor guanylyl cyclase signaling pathway cyclic nucleotide biosynthetic process positive regulation of cGMP-mediated signaling membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity natriuretic peptide receptor activity peptide hormone binding cGMP-mediated signaling reproductive process intracellular signal transduction hormone binding identical protein binding negative regulation of meiotic cell cycle bone development cellular response to granulocyte macrophage colony-stimulating factor stimulus negative regulation of oocyte maturation uc008sqm.1 uc008sqm.2 uc008sqm.3 
ENSMUST00000030192.5 Hint2 ENSMUST00000030192.5 histidine triad nucleotide binding protein 2 (from RefSeq NM_026871.1) ENSMUST00000030192.1 ENSMUST00000030192.2 ENSMUST00000030192.3 ENSMUST00000030192.4 HINT2_MOUSE Hint2 NM_026871 Q9D0S9 uc008sqs.1 uc008sqs.2 uc008sqs.3 Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes adenosine 5'-O-p- nitrophenylphosphoramidate (AMP-pNA) (By similarity). May be involved in steroid biosynthesis (By similarity). May play a role in apoptosis (By similarity). Reaction=adenosine 5'-phosphoramidate + H2O = AMP + NH4(+); Xref=Rhea:RHEA:67916, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57890, ChEBI:CHEBI:456215; Evidence=; Mitochondrion Belongs to the HINT family. nucleotide binding catalytic activity nucleolus mitochondrion lipid metabolic process steroid biosynthetic process apoptotic process lipid catabolic process hydrolase activity negative regulation of peptidyl-lysine acetylation uc008sqs.1 uc008sqs.2 uc008sqs.3 
ENSMUST00000030198.7 Reck ENSMUST00000030198.7 reversion-inducing-cysteine-rich protein with kazal motifs (from RefSeq NM_016678.3) B1AWM3 ENSMUST00000030198.1 ENSMUST00000030198.2 ENSMUST00000030198.3 ENSMUST00000030198.4 ENSMUST00000030198.5 ENSMUST00000030198.6 NM_016678 Q9Z0J1 RECK_MOUSE Reck uc012ddg.1 uc012ddg.2 Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28803732). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:26658478, PubMed:28803732). Acts as a Wnt7- specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (By similarity). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (By similarity). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:11747814). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:11747814). Interacts (via knot repeats) with WNT7A (via disordered linker region); the interaction is direct (By similarity). Interacts (via knot repeats) with WNT7B (via disordered linker region); the interaction is direct (By similarity). Interacts with ADGRA2; the interaction is direct (PubMed:28803732). Interacts with MMP9 (By similarity). Q9Z0J1; O00755: WNT7A; Xeno; NbExp=4; IntAct=EBI-20720091, EBI-727198; Q9Z0J1; P56706: WNT7B; Xeno; NbExp=4; IntAct=EBI-20720091, EBI-3913589; Cell membrane ; Lipid-anchor, GPI-anchor In 10.5 dpc embryos, widely expressed in mesenchymal tissues and is relatively abundant in the marginal zone of the neural tube and large blood vessels such as the aorta. The Kazal-like domains mediate the serine protease inhibitor activity. Embryonic lethality around 10.5 dpc, caused by reduced tissue integrity, arrested vasculogenesis and precocious neuronal differentiation (PubMed:11747814). Conditional knockout mice lacking Reck in endothelial cells show central nervous system (CNS) angiogenesis defects, characterized by moderate hemorrhages in the forebrain and vascular malformations in the cortex (PubMed:26658478, PubMed:28803732). Conditional deletion in endothelial cells also cause blood-brain barrier defects in neonates (PubMed:28803732). Phenotypes are caused by impaired beta-catenin-dependent signaling (PubMed:28803732). Belongs to the RECK family. vasculature development blood vessel maturation endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity protein binding plasma membrane embryo implantation metalloendopeptidase inhibitor activity negative regulation of peptidase activity membrane Wnt signaling pathway Wnt-protein binding extracellular matrix organization negative regulation of cell migration peptidase inhibitor activity anchored component of membrane embryonic forelimb morphogenesis regulation of angiogenesis canonical Wnt signaling pathway regulation of canonical Wnt signaling pathway regulation of establishment of blood-brain barrier positive regulation of canonical Wnt signaling pathway negative regulation of metalloendopeptidase activity coreceptor activity involved in canonical Wnt signaling pathway Wnt signalosome uc012ddg.1 uc012ddg.2 
ENSMUST00000030202.14 Glipr2 ENSMUST00000030202.14 GLI pathogenesis-related 2 (from RefSeq NM_027450.3) ENSMUST00000030202.1 ENSMUST00000030202.10 ENSMUST00000030202.11 ENSMUST00000030202.12 ENSMUST00000030202.13 ENSMUST00000030202.2 ENSMUST00000030202.3 ENSMUST00000030202.4 ENSMUST00000030202.5 ENSMUST00000030202.6 ENSMUST00000030202.7 ENSMUST00000030202.8 ENSMUST00000030202.9 GAPR1_MOUSE Gapr1 NM_027450 Q3TJ42 Q8BTK4 Q9CYL5 uc008srf.1 uc008srf.2 uc008srf.3 Homodimer. Interacts with CAV1 (By similarity). Golgi apparatus membrane; Lipid-anchor. Note=Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate. Belongs to the CRISP family. Golgi membrane extracellular region extracellular space Golgi apparatus positive regulation of epithelial cell migration positive regulation of epithelial to mesenchymal transition membrane protein homodimerization activity positive regulation of ERK1 and ERK2 cascade uc008srf.1 uc008srf.2 uc008srf.3 
ENSMUST00000030206.10 Snapc3 ENSMUST00000030206.10 small nuclear RNA activating complex, polypeptide 3, transcript variant 1 (from RefSeq NM_029949.4) ENSMUST00000030206.1 ENSMUST00000030206.2 ENSMUST00000030206.3 ENSMUST00000030206.4 ENSMUST00000030206.5 ENSMUST00000030206.6 ENSMUST00000030206.7 ENSMUST00000030206.8 ENSMUST00000030206.9 NM_029949 Q8C0A5 Q9D2C9 SNPC3_MOUSE uc008tku.1 uc008tku.2 uc008tku.3 Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity). Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1 (By similarity). Nucleus Belongs to the SNAPC3/SRD2 family. DNA binding nucleus nucleoplasm nucleolus nuclear body uc008tku.1 uc008tku.2 uc008tku.3 
ENSMUST00000030207.15 Psip1 ENSMUST00000030207.15 PC4 and SFRS1 interacting protein 1, transcript variant 1 (from RefSeq NM_133948.6) A2BI10 A2BI11 ENSMUST00000030207.1 ENSMUST00000030207.10 ENSMUST00000030207.11 ENSMUST00000030207.12 ENSMUST00000030207.13 ENSMUST00000030207.14 ENSMUST00000030207.2 ENSMUST00000030207.3 ENSMUST00000030207.4 ENSMUST00000030207.5 ENSMUST00000030207.6 ENSMUST00000030207.7 ENSMUST00000030207.8 ENSMUST00000030207.9 Ledgf NM_133948 PSIP1_MOUSE Q3TEJ7 Q3TTD7 Q3UTA1 Q80WQ7 Q99JF7 Q99JF8 Q99LR4 Q9CT03 uc008tkw.1 uc008tkw.2 uc008tkw.3 uc008tkw.4 uc008tkw.5 Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity). Monomer (By similarity). Interacts with IFRD1/PC4 (By similarity). Interacts (via IBD domain) with POGZ (via IBM motif) and CDCA7L (via IBM motifs) (By similarity). Interacts (via IBD domain) with KMT2A (via IBM motifs) with a moderate affinity whereas interacts with the KMT2A-MEN1 complex with a greater affinity; MEN1 enhances interaction of KMT2A with PSIP1 (By similarity). Interacts (via IBD domain) with IWS1 (via IBM motif), MED1 (via IBM motif) and DBF4 (via IBM motifs) (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Ledgfa, p75; IsoId=Q99JF8-1; Sequence=Displayed; Name=2; Synonyms=Ledgfb, p52; IsoId=Q99JF8-2; Sequence=VSP_014299, VSP_014300; Citrullinated by PADI4. Belongs to the HDGF family. mRNA 5'-splice site recognition DNA binding chromatin binding transcription coactivator activity nucleus nucleoplasm nuclear heterochromatin response to oxidative stress response to heat activating transcription factor binding nuclear periphery transcriptionally active chromatin positive regulation of transcription from RNA polymerase II promoter supercoiled DNA binding uc008tkw.1 uc008tkw.2 uc008tkw.3 uc008tkw.4 uc008tkw.5 
ENSMUST00000030212.15 Sh3gl2 ENSMUST00000030212.15 SH3-domain GRB2-like 2, transcript variant 1 (from RefSeq NM_019535.3) ENSMUST00000030212.1 ENSMUST00000030212.10 ENSMUST00000030212.11 ENSMUST00000030212.12 ENSMUST00000030212.13 ENSMUST00000030212.14 ENSMUST00000030212.2 ENSMUST00000030212.3 ENSMUST00000030212.4 ENSMUST00000030212.5 ENSMUST00000030212.6 ENSMUST00000030212.7 ENSMUST00000030212.8 ENSMUST00000030212.9 Een1 NM_019535 Q3UTL7 Q3UY49 Q62420 Q8BXS6 Q8VBV1 SH3G2_MOUSE Sh3d2a uc008tlo.1 uc008tlo.2 uc008tlo.3 uc008tlo.4 Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth (PubMed:21849472). Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (PubMed:21849472). Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). Interacts with SYNJ1 (By similarity). Interacts with DNM1 (PubMed:10490020). Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation (By similarity). Interacts with OPHN1 (PubMed:19481455). Interacts with PDCD6IP (By similarity). Interacts with BIN2 (By similarity). Interacts with ATXN2 (PubMed:18602463). Interacts with ADAM9 and ADAM15 cytoplasmic tails (PubMed:10531379). Interacts with TMEM108 (PubMed:21849472). Interacts with ADGRB2 (PubMed:28891236). Q62420; Q8K382: Dennd1a; NbExp=2; IntAct=EBI-77971, EBI-7186684; Q62420; Q62420: Sh3gl2; NbExp=2; IntAct=EBI-77971, EBI-77971; Cytoplasm Membrane ; Peripheral membrane protein Early endosome Presynapse An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes (By similarity). The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface. Belongs to the endophilin family. Was originally thought to have lysophosphatidic acid acyltransferase activity, but has since been experimentally shown not to have this activity. regulation of receptor internalization protein binding cytoplasm endosome early endosome cytosol endocytosis protein C-terminus binding lipid binding membrane synaptic vesicle uncoating protein kinase binding synaptic vesicle membrane neuron projection development identical protein binding protein homodimerization activity neuronal cell body synapse perinuclear region of cytoplasm synaptic vesicle endocytosis lipid tube assembly basilar dendrite dendrite extension membrane tubulation presynapse glutamatergic synapse vesicle scission presynaptic cytosol positive regulation of membrane tubulation cellular response to brain-derived neurotrophic factor stimulus regulation of clathrin-dependent endocytosis uc008tlo.1 uc008tlo.2 uc008tlo.3 uc008tlo.4 
ENSMUST00000030216.6 Saxo1 ENSMUST00000030216.6 stabilizer of axonemal microtubules 1 (from RefSeq NM_001081096.1) B1AXP3 B1AXP3_MOUSE ENSMUST00000030216.1 ENSMUST00000030216.2 ENSMUST00000030216.3 ENSMUST00000030216.4 ENSMUST00000030216.5 NM_001081096 Saxo1 uc008tlt.1 uc008tlt.2 uc008tlt.3 Belongs to the FAM154 family. centriole cytoskeleton axonemal microtubule microtubule binding cold acclimation motile cilium microtubule anchoring ciliary basal body sperm flagellum positive regulation of cilium assembly protein stabilization cellular response to cold uc008tlt.1 uc008tlt.2 uc008tlt.3 
ENSMUST00000030221.3 Hacd4 ENSMUST00000030221.3 3-hydroxyacyl-CoA dehydratase 4, transcript variant 2 (from RefSeq NM_025760.5) A2AKM1 A2AKM2 ENSMUST00000030221.1 ENSMUST00000030221.2 HACD4_MOUSE Hacd4 NM_025760 Ptplad2 Q8BG85 Q9CPS2 uc008tmy.1 uc008tmy.2 uc008tmy.3 Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Reaction=a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O; Xref=Rhea:RHEA:45812, ChEBI:CHEBI:15377, ChEBI:CHEBI:83728, ChEBI:CHEBI:85440; EC=4.2.1.134; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45813; Evidence=; Reaction=(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O; Xref=Rhea:RHEA:39159, ChEBI:CHEBI:15377, ChEBI:CHEBI:61526, ChEBI:CHEBI:74278; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39160; Evidence=; Lipid metabolism; fatty acid biosynthesis. May interact with enzymes of the ELO family (including ELOVL1); with those enzymes that mediate condensation, the first of the four steps of the reaction cycle responsible for fatty acids elongation, may be part of a larger fatty acids elongase complex. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AKM2-1; Sequence=Displayed; Name=2; IsoId=A2AKM2-2; Sequence=VSP_030124; Belongs to the very long-chain fatty acids dehydratase HACD family. Shares some similarity with tyrosine phosphatase proteins but it has probably no phosphatase activity. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process membrane integral component of membrane lyase activity 3-hydroxyacyl-CoA dehydratase activity enzyme binding sphingolipid biosynthetic process integral component of endoplasmic reticulum membrane fatty acid elongation very long-chain fatty acid biosynthetic process 3-hydroxy-behenoyl-CoA dehydratase activity 3-hydroxy-lignoceroyl-CoA dehydratase activity uc008tmy.1 uc008tmy.2 uc008tmy.3 
ENSMUST00000030243.8 Prkaa2 ENSMUST00000030243.8 protein kinase, AMP-activated, alpha 2 catalytic subunit, transcript variant 1 (from RefSeq NM_178143.2) AAPK2_MOUSE B1ASQ8 ENSMUST00000030243.1 ENSMUST00000030243.2 ENSMUST00000030243.3 ENSMUST00000030243.4 ENSMUST00000030243.5 ENSMUST00000030243.6 ENSMUST00000030243.7 NM_178143 Prkaa2 Q3UYM4 Q8BRK8 uc008tyd.1 uc008tyd.2 uc008tyd.3 uc008tyd.4 Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (By similarity). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (By similarity). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (By similarity). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:15331533, PubMed:15561936). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (PubMed:16804075, PubMed:16804077). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:21454484, PubMed:20647423, PubMed:21459323, PubMed:17609368). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (PubMed:16148943, PubMed:16308421). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (PubMed:20647423). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:18439900, PubMed:21258367, PubMed:21205641, PubMed:32912901). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (By similarity). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (By similarity). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21258367, PubMed:21205641). In that process also activates WDR45/WIPI4 (By similarity). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (By similarity). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (PubMed:19833968). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (PubMed:20361929). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (By similarity). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (PubMed:23332761). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (PubMed:23332761). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (By similarity). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser- 659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O- phospho-L-seryl-[acetyl-CoA carboxylase]; Xref=Rhea:RHEA:20333, Rhea:RHEA-COMP:13722, Rhea:RHEA-COMP:13723, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; Evidence=; Reaction=ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3- methylglutaryl-coenzyme A reductase]; Xref=Rhea:RHEA:23172, Rhea:RHEA-COMP:13692, Rhea:RHEA-COMP:13693, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.31; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation on Thr-172. Binding of AMP to non-catalytic gamma subunit (PRKAG1, PRKAG2 or PRKAG3) results in allosteric activation, inducing phosphorylation on Thr-172. AMP-binding to gamma subunit also sustains activity by preventing dephosphorylation of Thr-172. ADP also stimulates Thr-172 phosphorylation, without stimulating already phosphorylated AMPK. ATP promotes dephosphorylation of Thr-172, rendering the enzyme inactive. Under physiological conditions AMPK mainly exists in its inactive form in complex with ATP, which is much more abundant than AMP. Selectively inhibited by compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3- pyridin-4-yl-pyyrazolo[1,5-a] pyrimidine. Activated by resveratrol, a natural polyphenol present in red wine, and S17834, a synthetic polyphenol. Salicylate/aspirin directly activates kinase activity, primarily by inhibiting Thr-172 dephosphorylation. AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity). Interacts with DUSP29 (PubMed:30201684). Interacts with ARF6 (By similarity). The phosphorylated form at Thr-172 mediated by CamKK2 interacts with ACSS2 (By similarity). Cytoplasm Nucleus Note=In response to stress, recruited by p53/TP53 to specific promoters. The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity. Ubiquitinated. Phosphorylated at Thr-172 by STK11/LKB1 in complex with STE20- related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-172 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-172, but at much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. Dephosphorylated by PPM1A and PPM1B at Thr-172 (mediated by STK11/LKB1) (By similarity). Mice develop obesity when animals are fed a high- fat diet, as a result of an enhanced lipid accumulation in pre-existing adipocytes but not in other tissues. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. nucleotide binding chromatin binding protein kinase activity protein serine/threonine kinase activity AMP-activated protein kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm Golgi apparatus cytosol chromatin organization protein phosphorylation lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process steroid biosynthetic process cholesterol biosynthetic process autophagy steroid metabolic process cholesterol metabolic process lipid biosynthetic process regulation of gene expression cytoplasmic stress granule positive regulation of autophagy negative regulation of gene expression response to activity response to muscle activity Wnt signaling pathway sterol biosynthetic process regulation of macroautophagy kinase activity phosphorylation apical plasma membrane nuclear speck transferase activity regulation of lipid metabolic process axon dendrite protein binding, bridging response to caffeine nucleotide-activated protein kinase complex cellular response to nutrient levels negative regulation of TOR signaling macromolecular complex cellular response to oxidative stress histone serine kinase activity histone-serine phosphorylation intracellular signal transduction cellular response to drug cellular response to glucose starvation glucose homeostasis regulation of circadian rhythm neuronal cell body negative regulation of apoptotic process positive regulation of glycolytic process metal ion binding [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity rhythmic process [acetyl-CoA carboxylase] kinase activity protein heterooligomerization fatty acid homeostasis regulation of microtubule cytoskeleton organization cellular response to calcium ion cellular response to glucose stimulus cellular response to prostaglandin E stimulus energy homeostasis positive regulation of cellular protein localization negative regulation of tubulin deacetylation positive regulation of peptidyl-lysine acetylation uc008tyd.1 uc008tyd.2 uc008tyd.3 uc008tyd.4 
ENSMUST00000030245.10 4921539E11Rik ENSMUST00000030245.10 RIKEN cDNA 4921539E11 gene, transcript variant 1 (from RefSeq NM_027612.1) A2AKQ4 CA141_MOUSE ENSMUST00000030245.1 ENSMUST00000030245.2 ENSMUST00000030245.3 ENSMUST00000030245.4 ENSMUST00000030245.5 ENSMUST00000030245.6 ENSMUST00000030245.7 ENSMUST00000030245.8 ENSMUST00000030245.9 NM_027612 Q3KN93 Q3KN94 Q3TTD9 Q9D5Q8 uc008txp.1 uc008txp.2 uc008txp.3 uc008txp.4 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D5Q8-1; Sequence=Displayed; Name=2; IsoId=Q9D5Q8-2; Sequence=VSP_026645; Name=3; IsoId=Q9D5Q8-3; Sequence=VSP_026646, VSP_026647; molecular_function cellular_component biological_process uc008txp.1 uc008txp.2 uc008txp.3 uc008txp.4 
ENSMUST00000030254.15 Leprot ENSMUST00000030254.15 leptin receptor overlapping transcript, transcript variant 3 (from RefSeq NR_185080.1) A2AV64 ENSMUST00000030254.1 ENSMUST00000030254.10 ENSMUST00000030254.11 ENSMUST00000030254.12 ENSMUST00000030254.13 ENSMUST00000030254.14 ENSMUST00000030254.2 ENSMUST00000030254.3 ENSMUST00000030254.4 ENSMUST00000030254.5 ENSMUST00000030254.6 ENSMUST00000030254.7 ENSMUST00000030254.8 ENSMUST00000030254.9 Lepr NR_185080 O89013 OBRG_MOUSE Obr Q3TGT4 Q3TWZ2 Q545G9 Q91Z23 uc008tvu.1 uc008tvu.2 uc008tvu.3 Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Interacts with LEPR. Interacts with RAB13 (By similarity). Golgi apparatus membrane ; Multi-pass membrane protein Endosome membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O89013-1; Sequence=Displayed; Name=2; IsoId=O89013-2; Sequence=VSP_039718; Widely distributed in the brain, with elevated expression in the hypothalamic regions, including the paraventricular nucleus. In the placenta, present at high levels in the junctional zone situated towards the maternal aspect and throughout the labyrinth zone in close proximity to the developing fetus. Up-regulated in the liver of fasting animals. [Isoform 2]: May be due to competing acceptor splice site. Belongs to the OB-RGRP/VPS55 family. This protein is encoded by the leptin receptor (LEPR) gene, but shares with LEPR only the first two 5'-UTR exons. It therefore does not share any sequence similarity with LEPR. Golgi membrane receptor binding protein binding endosome Golgi apparatus endosome membrane membrane integral component of membrane late endosome to vacuole transport via multivesicular body sorting pathway negative regulation of JAK-STAT cascade negative regulation of growth hormone receptor signaling pathway negative regulation of protein localization to cell surface uc008tvu.1 uc008tvu.2 uc008tvu.3 
ENSMUST00000030257.15 Cachd1 ENSMUST00000030257.15 cache domain containing 1 (from RefSeq NM_198037.2) A2A8W3 CAHD1_MOUSE ENSMUST00000030257.1 ENSMUST00000030257.10 ENSMUST00000030257.11 ENSMUST00000030257.12 ENSMUST00000030257.13 ENSMUST00000030257.14 ENSMUST00000030257.2 ENSMUST00000030257.3 ENSMUST00000030257.4 ENSMUST00000030257.5 ENSMUST00000030257.6 ENSMUST00000030257.7 ENSMUST00000030257.8 ENSMUST00000030257.9 Kiaa1573 NM_198037 Q6PDJ1 Q6PFZ0 Q6ZPM4 Q8BNP3 Vwcd1 uc008tvh.1 uc008tvh.2 uc008tvh.3 uc008tvh.4 May regulate voltage-dependent calcium channels. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PDJ1-1; Sequence=Displayed; Name=2; IsoId=Q6PDJ1-2; Sequence=VSP_028073; Belongs to the calcium channel subunit alpha-2/delta family. Sequence=CAM20140.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM22543.1; Type=Erroneous gene model prediction; Evidence=; voltage-gated calcium channel activity voltage-gated calcium channel complex ion transport calcium ion transport biological_process membrane integral component of membrane calcium ion transmembrane transport uc008tvh.1 uc008tvh.2 uc008tvh.3 uc008tvh.4 
ENSMUST00000030261.6 2610528J11Rik ENSMUST00000030261.6 RIKEN cDNA 2610528J11 gene, transcript variant 1 (from RefSeq NM_025572.3) CA210_MOUSE ENSMUST00000030261.1 ENSMUST00000030261.2 ENSMUST00000030261.3 ENSMUST00000030261.4 ENSMUST00000030261.5 NM_025572 Q9CQM1 uc008ukj.1 uc008ukj.2 uc008ukj.3 May be involved in membrane trafficking between endosomes and plasma membrane. Membrane ; Single-pass type III membrane protein Early endosome Recycling endosome Cell membrane Note=Also localizes to tubular endosome structures. Expressed in stomach, kidney, large and small intestine and kidney. molecular_function endosome early endosome plasma membrane membrane integral component of membrane recycling endosome uc008ukj.1 uc008ukj.2 uc008ukj.3 
ENSMUST00000030265.4 Dph2 ENSMUST00000030265.4 DPH2 homolog, transcript variant 1 (from RefSeq NM_026344.4) DPH2_MOUSE Dph2l2 ENSMUST00000030265.1 ENSMUST00000030265.2 ENSMUST00000030265.3 NM_026344 Q8K0L8 Q9CR25 uc008ujd.1 uc008ujd.2 uc008ujd.3 Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:15485916). DPH1 and DPH2 transfer a 3-amino-3- carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity). Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the DPH1 subunit. ; Protein modification; peptidyl-diphthamide biosynthesis. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase (By similarity). Interacts with DPH1 (PubMed:15485916, PubMed:21203470). Q9CR25; Q5NCQ5: Dph1; NbExp=2; IntAct=EBI-1561134, EBI-1561119; Belongs to the DPH1/DPH2 family. DPH2 subfamily. protein binding cellular_component transferase activity peptidyl-diphthamide biosynthetic process from peptidyl-histidine 2-(3-amino-3-carboxypropyl)histidine synthase activity uc008ujd.1 uc008ujd.2 uc008ujd.3 
ENSMUST00000030266.12 B4galt2 ENSMUST00000030266.12 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2, transcript variant 5 (from RefSeq NR_189666.1) B4GT2_MOUSE B4galt2 ENSMUST00000030266.1 ENSMUST00000030266.10 ENSMUST00000030266.11 ENSMUST00000030266.2 ENSMUST00000030266.3 ENSMUST00000030266.4 ENSMUST00000030266.5 ENSMUST00000030266.6 ENSMUST00000030266.7 ENSMUST00000030266.8 ENSMUST00000030266.9 NR_189666 Q3TMP2 Q9Z2Y2 uc008ujb.1 uc008ujb.2 uc008ujb.3 uc008ujb.4 Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose (By similarity). Reaction=D-glucose + UDP-alpha-D-galactose = H(+) + lactose + UDP; Xref=Rhea:RHEA:12404, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378, ChEBI:CHEBI:17716, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914; EC=2.4.1.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12405; Evidence=; Reaction=an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D- galactose = a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:22932, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:61631, ChEBI:CHEBI:66914, ChEBI:CHEBI:133507; EC=2.4.1.38; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22933; Evidence=; Reaction=N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D- galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP; Xref=Rhea:RHEA:17745, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:60152, ChEBI:CHEBI:66914, ChEBI:CHEBI:506227; EC=2.4.1.90; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17746; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Note=Trans cisternae of Golgi stack. Belongs to the glycosyltransferase 7 family. Name=Functional Glycomics Gateway - GTase; Note=b4GalT2; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_461"; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity N-acetyllactosamine synthase activity lactose synthase activity nucleoplasm Golgi apparatus carbohydrate metabolic process protein glycosylation brain development memory locomotory behavior visual learning membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups cerebellar Purkinje cell layer development Golgi cisterna membrane intracellular membrane-bounded organelle metal ion binding uc008ujb.1 uc008ujb.2 uc008ujb.3 uc008ujb.4 
ENSMUST00000030274.7 Bend5 ENSMUST00000030274.7 BEN domain containing 5, transcript variant 2 (from RefSeq NR_033793.1) BEND5_MOUSE ENSMUST00000030274.1 ENSMUST00000030274.2 ENSMUST00000030274.3 ENSMUST00000030274.4 ENSMUST00000030274.5 ENSMUST00000030274.6 NR_033793 Q3TJI2 Q80V74 Q80WB6 Q8C6D4 Q9CRW0 uc008ude.1 uc008ude.2 uc008ude.3 Acts as a transcriptional repressor. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C6D4-1; Sequence=Displayed; Name=2; IsoId=Q8C6D4-2; Sequence=VSP_022696; The BEN domain mediates DNA-binding. molecular_function DNA binding Golgi apparatus negative regulation of transcription, DNA-templated uc008ude.1 uc008ude.2 uc008ude.3 
ENSMUST00000030279.15 Atg4c ENSMUST00000030279.15 autophagy related 4C, cysteine peptidase, transcript variant 1 (from RefSeq NM_175029.3) ATG4C_MOUSE Apg4c Atg4c Autl3 B1ASJ9 ENSMUST00000030279.1 ENSMUST00000030279.10 ENSMUST00000030279.11 ENSMUST00000030279.12 ENSMUST00000030279.13 ENSMUST00000030279.14 ENSMUST00000030279.2 ENSMUST00000030279.3 ENSMUST00000030279.4 ENSMUST00000030279.5 ENSMUST00000030279.6 ENSMUST00000030279.7 ENSMUST00000030279.8 ENSMUST00000030279.9 NM_175029 Q6PD25 Q811C2 uc008tuu.1 uc008tuu.2 Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (By similarity). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE- conjugated forms of ATG8 proteins during macroautophagy. Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity. In contrast to other members of the family, weakly or not involved in phagophore growth during mitophagy (By similarity). Reaction=[protein]-C-terminal L-amino acid-glycyl- phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid- glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:67548, Rhea:RHEA-COMP:17323, Rhea:RHEA-COMP:17324, ChEBI:CHEBI:15377, ChEBI:CHEBI:64612, ChEBI:CHEBI:172940, ChEBI:CHEBI:172941; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67549; Evidence=; Inhibited by N-ethylmaleimide. Cytoplasm Belongs to the peptidase C54 family. Was reported that this protein is required for a proper autophagic response under stressful conditions such as prolonged starvation, based on experiments conducted on cells or mice claimed to have null alleles (PubMed:17442669). However, this paper has been retracted because of aberrations in the relevant figure (PubMed:30808006). Nevertheless, a separate experiment in the same paper suggests that the alleles are null and so the inferred function may be true. cysteine-type endopeptidase activity cytoplasm proteolysis autophagy peptidase activity cysteine-type peptidase activity protein transport hydrolase activity uc008tuu.1 uc008tuu.2 
ENSMUST00000030280.7 Angptl3 ENSMUST00000030280.7 angiopoietin-like 3 (from RefSeq NM_013913.4) ANGL3_MOUSE ENSMUST00000030280.1 ENSMUST00000030280.2 ENSMUST00000030280.3 ENSMUST00000030280.4 ENSMUST00000030280.5 ENSMUST00000030280.6 NM_013913 Q9R182 uc008tur.1 uc008tur.2 uc008tur.3 uc008tur.4 This gene encodes a member of the angiopoietin-like family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may inhibit triglyceride metabolism. Homozygous knockout mice for this gene exhibit reduced plasma lipid concentrations, including reduced plasma triglyceride concentrations, and enhanced activity of enzymes involved in triglyceride metabolism. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149450.1, AK149555.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism (PubMed:11788823, PubMed:12671033). Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (PubMed:26305978). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity; the function seems to be specific for the feeding conditions. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1 (PubMed:12909640, PubMed:16081640, PubMed:20581395). Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids; the cleaved N-terminal domain is more efficient than the uncleaved proprotein (PubMed:17681148). Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (By similarity). Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food; the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT (PubMed:26305978). Contributes to lower plasma levels of low density lipoprotein (LDL)-cholesterol by a mechanism that is independent of the canonical pathway implicating APOE and LDLR (PubMed:25954050). May stimulate hypothalamic LPL activity (PubMed:25338813). Involved in angiogenesis (PubMed:11877390). Binds to endothelial cells via integrin alpha-V/beta-3 (ITGAV:ITGB3), activates FAK, MAPK and Akt signaling pathways and induces cell adhesion and cell migration (By similarity). May increase the motility of podocytes. Secreted from podocytes, may modulate properties of glomerular endothelial cells involving integrin alpha-V/beta-3 and Akt signaling (By similarity). May induce actin filament rearrangements in podocytes implicating integrin alpha-V/beta-3 and Rac1 activation (PubMed:20633534, PubMed:24294595, PubMed:25710887). Binds to hematopoietic stem cells (HSC) and is involved in the regulation of HSC activity probably implicating down-regulation of IKZF1/IKAROS (PubMed:20959605). Interacts with ANGPTL8 (By similarity). Interacts with ITGB3. Secreted Cell projection, lamellipodium Note=Colocalized with HSPG2 and activated ITGB3 on podocytes. Predominantly expressed in liver, weakly expressed in kidney and lung. Expressed in podocytes (at protein level). Expressed in hypothalamic neurons (at protein level). Expressed in bone marrow sinusoidal endothelial cells (at protein level). Down-regulated by insulin and leptin. Not regulated by nutritional status (fed/fasting) Up-regulated in podocytes by puromycin. Up-regulated after feeding in the hypothalamus. The fibrinogen C-terminal domain is sufficient to mediate endothelial cell adhesion. In part proteolytically cleaved by proprotein convertases; proposed to be involved in activation. In primary hepatocytes is intracellularily predominantly processed by FURIN and extracellularily by FURIN and PCSK6/PACE4. In 18.5 dpc embryos 75% of protein is found to be processed compared to 25 % in adults. Low plasma levels of triglyceride, HDL cholesterol and HDL phospholipids, and non-esterified fatty acids (NEFA). Animals fed on high-fat, high-calorie (HFC) diet show reduced epididymal adipose tissue weight with no difference in adipocyte size. Hypotriglyceridemia with elevated postheparin plasma LPL activity is specifically observed in the fed state. Mice deficient in both Angptl3 and Angptl4 show an additive effect on plasma triglycerides and did not survive past 2 months of age. Was suggested to inhibit LPL through a direct mechanism; however, the necessary concentrations to achieve the in vitro inhibition are at least 30-fold higher than ANGPTL3 plasma concentrations. angiogenesis enzyme inhibitor activity phospholipase inhibitor activity integrin binding extracellular region extracellular space early endosome Golgi apparatus glycerol metabolic process lipid metabolic process fatty acid metabolic process triglyceride metabolic process phospholipid metabolic process cell adhesion cell-matrix adhesion signal transduction growth factor activity heparin binding cholesterol metabolic process phospholipid catabolic process response to hormone cell surface negative regulation of phospholipase activity lipid storage lamellipodium positive regulation of cell migration cholesterol homeostasis cell projection positive regulation of angiogenesis positive regulation of lipid metabolic process artery morphogenesis positive regulation of lipid catabolic process negative regulation of lipoprotein lipase activity lipid homeostasis acylglycerol homeostasis phospholipid homeostasis triglyceride homeostasis uc008tur.1 uc008tur.2 uc008tur.3 uc008tur.4 
ENSMUST00000030284.10 Rnf11 ENSMUST00000030284.10 ring finger protein 11 (from RefSeq NM_013876.3) B1AU36 B1AU37 ENSMUST00000030284.1 ENSMUST00000030284.2 ENSMUST00000030284.3 ENSMUST00000030284.4 ENSMUST00000030284.5 ENSMUST00000030284.6 ENSMUST00000030284.7 ENSMUST00000030284.8 ENSMUST00000030284.9 N4wbp2 NM_013876 Q9EQI1 Q9QYK7 RNF11_MOUSE Sid1669 uc008ucl.1 uc008ucl.2 uc008ucl.3 Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys- 63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys- 48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome. Interacts (when phosphorylated) with 14-3-3. Interacts with the E3 ubiquitin-ligases NEDD4, ITCH, SMURF2 and WWP1 (By similarity). Also interacts with the E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2N, but neither with CDC34, nor with UBE2L3. Interacts with ZNF350, EPS15 and STAMBP (By similarity). After TNF stimulation, interacts with TAX1BP1, TNFAIP3 and RIPK1; these interactions are transient and they are lost after 1 hour of stimulation with TNF. Interacts with GGA1 (By similarity). Q9QYK7; P46935: Nedd4; NbExp=4; IntAct=EBI-4405826, EBI-773516; Early endosome Recycling endosome Cytoplasm Nucleus Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1. The PPxY motif mediates interaction with NEDD4. Ubiquitinated in the presence of ITCH, SMURF2 and UBE2D1, as well as WWP1. Phosphorylation by PKB/AKT1 may accelerate degradation by the proteasome. Acylation at both Gly-2 and Cys-4 is required for proper localization to the endosomes. Sequence=AAG44245.1; Type=Erroneous initiation; Evidence=; ubiquitin ligase complex ubiquitin-protein transferase activity protein binding nucleus cytoplasm endosome early endosome ubiquitin-dependent protein catabolic process metal ion binding protein autoubiquitination recycling endosome uc008ucl.1 uc008ucl.2 uc008ucl.3 
ENSMUST00000030285.8 Calr4 ENSMUST00000030285.8 calreticulin 4, transcript variant 1 (from RefSeq NM_001285895.1) Calr4 ENSMUST00000030285.1 ENSMUST00000030285.2 ENSMUST00000030285.3 ENSMUST00000030285.4 ENSMUST00000030285.5 ENSMUST00000030285.6 ENSMUST00000030285.7 NM_001285895 Q3TQS0 Q3TQS0_MOUSE uc008uce.1 uc008uce.2 uc008uce.3 uc008uce.4 Endoplasmic reticulum lumen Belongs to the calreticulin family. calcium ion binding endoplasmic reticulum endoplasmic reticulum membrane protein folding endoplasmic reticulum unfolded protein response metal ion binding unfolded protein binding uc008uce.1 uc008uce.2 uc008uce.3 uc008uce.4 
ENSMUST00000030286.14 Dock7 ENSMUST00000030286.14 dedicator of cytokinesis 7, transcript variant 1 (from RefSeq NM_001290636.2) A2A9M5 A2A9M5_MOUSE Dock7 ENSMUST00000030286.1 ENSMUST00000030286.10 ENSMUST00000030286.11 ENSMUST00000030286.12 ENSMUST00000030286.13 ENSMUST00000030286.2 ENSMUST00000030286.3 ENSMUST00000030286.4 ENSMUST00000030286.5 ENSMUST00000030286.6 ENSMUST00000030286.7 ENSMUST00000030286.8 ENSMUST00000030286.9 NM_001290636 uc008tuo.1 uc008tuo.2 uc008tuo.3 uc008tuo.4 Belongs to the DOCK family. microtubule cytoskeleton organization guanyl-nucleotide exchange factor activity small GTPase mediated signal transduction axonogenesis COP9 signalosome neuron projection development positive regulation of peptidyl-serine phosphorylation establishment of neuroblast polarity Rac GTPase binding activation of GTPase activity positive regulation of vascular associated smooth muscle cell migration uc008tuo.1 uc008tuo.2 uc008tuo.3 uc008tuo.4 
ENSMUST00000030289.9 Usp1 ENSMUST00000030289.9 ubiquitin specific peptidase 1, transcript variant 2 (from RefSeq NM_146144.4) ENSMUST00000030289.1 ENSMUST00000030289.2 ENSMUST00000030289.3 ENSMUST00000030289.4 ENSMUST00000030289.5 ENSMUST00000030289.6 ENSMUST00000030289.7 ENSMUST00000030289.8 NM_146144 Q8BJQ2 Q8VE17 Q8VEM4 UBP1_MOUSE Usp1 uc008tum.1 uc008tum.2 uc008tum.3 uc008tum.4 This gene encodes a member of the ubiquitin-specific peptidase family. The encoded protein acts as a catalytic subunit in a heterodimeric deubiquitinating enzyme complex that deubiquitinates Fanconi anemia, complementation group D2, and plays a role in homologous recombination-mediated DNA repair. Disruption of this gene is associated with a Fanconi anemia-like phenotype and genomic instability. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 3, 12, and 15. [provided by RefSeq, Aug 2014]. Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA- mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with FANCD2 and PCNA. Interacts with WDR48. Interacts with ATAD5; the interaction regulates USP1-mediated PCNA deubiquitination. Nucleus Autocatalytic cleavage of USP1 following UV irradiation inactivates it, leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis. [Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment]: Ubiquitinated by the CRL2(KLHDC2) complex following autocatalytic cleavage, leading to its degradation: the CRL2(KLHDC2) complex recognizes the diglycine (Gly-Gly) at the C-terminus. Belongs to the peptidase C19 family. skeletal system development cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus nucleoplasm DNA repair regulation of DNA repair proteolysis ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus peptidase activity cysteine-type peptidase activity response to UV protein deubiquitination hydrolase activity monoubiquitinated protein deubiquitination thiol-dependent ubiquitinyl hydrolase activity uc008tum.1 uc008tum.2 uc008tum.3 uc008tum.4 
ENSMUST00000030296.9 Txndc12 ENSMUST00000030296.9 thioredoxin domain containing 12 (endoplasmic reticulum) (from RefSeq NM_025334.3) ENSMUST00000030296.1 ENSMUST00000030296.2 ENSMUST00000030296.3 ENSMUST00000030296.4 ENSMUST00000030296.5 ENSMUST00000030296.6 ENSMUST00000030296.7 ENSMUST00000030296.8 NM_025334 Q53YN1 Q9CQU0 TXD12_MOUSE Tlp19 Txndc12 uc008ubs.1 uc008ubs.2 uc008ubs.3 uc008ubs.4 Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol- disulfide oxidase activity. Reaction=[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide; Xref=Rhea:RHEA:21064, Rhea:RHEA-COMP:10593, Rhea:RHEA-COMP:10594, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.8.4.2; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21066; Evidence=; Endoplasmic reticulum lumen endoplasmic reticulum endoplasmic reticulum lumen peptide disulfide oxidoreductase activity oxidoreductase activity protein-disulfide reductase (glutathione) activity cell redox homeostasis oxidation-reduction process negative regulation of cell death negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway uc008ubs.1 uc008ubs.2 uc008ubs.3 uc008ubs.4 
ENSMUST00000030299.8 Cyp2j5 ENSMUST00000030299.8 cytochrome P450, family 2, subfamily j, polypeptide 5, transcript variant 1 (from RefSeq NM_010007.5) Cyp2j5 ENSMUST00000030299.1 ENSMUST00000030299.2 ENSMUST00000030299.3 ENSMUST00000030299.4 ENSMUST00000030299.5 ENSMUST00000030299.6 ENSMUST00000030299.7 NM_010007 Q3TNC5 Q3TNC5_MOUSE uc008ttl.1 uc008ttl.2 uc008ttl.3 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding metal ion binding oxidation-reduction process uc008ttl.1 uc008ttl.2 uc008ttl.3 
ENSMUST00000030303.6 Cyp2j6 ENSMUST00000030303.6 cytochrome P450, family 2, subfamily j, polypeptide 6, transcript variant 5 (from RefSeq NR_185203.1) CP2J6_MOUSE ENSMUST00000030303.1 ENSMUST00000030303.2 ENSMUST00000030303.3 ENSMUST00000030303.4 ENSMUST00000030303.5 NR_185203 O54750 Q8BR78 uc008tti.1 uc008tti.2 uc008tti.3 uc008tti.4 Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Belongs to the cytochrome P450 family. retinoid metabolic process NADPH-hemoprotein reductase activity monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process icosanoid metabolic process xenobiotic metabolic process female pregnancy arachidonic acid epoxygenase activity steroid hydroxylase activity arachidonic acid 14,15-epoxygenase activity arachidonic acid 11,12-epoxygenase activity response to organic cyclic compound membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen isomerase activity arachidonic acid metabolic process epoxygenase P450 pathway heme binding organelle membrane negative regulation of collagen biosynthetic process negative regulation of peroxisome proliferator activated receptor signaling pathway exogenous drug catabolic process intracellular membrane-bounded organelle linoleic acid metabolic process metal ion binding oxidation-reduction process aromatase activity linoleic acid epoxygenase activity positive regulation of tumor necrosis factor secretion uc008tti.1 uc008tti.2 uc008tti.3 uc008tti.4 
ENSMUST00000030305.13 Cyp2j13 ENSMUST00000030305.13 cytochrome P450, family 2, subfamily j, polypeptide 13, transcript variant 1 (from RefSeq NM_145548.4) Cyp2j13 ENSMUST00000030305.1 ENSMUST00000030305.10 ENSMUST00000030305.11 ENSMUST00000030305.12 ENSMUST00000030305.2 ENSMUST00000030305.3 ENSMUST00000030305.4 ENSMUST00000030305.5 ENSMUST00000030305.6 ENSMUST00000030305.7 ENSMUST00000030305.8 ENSMUST00000030305.9 NM_145548 Q3UNV4 Q3UNV4_MOUSE uc008tte.1 uc008tte.2 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc008tte.1 uc008tte.2 
ENSMUST00000030306.14 Hook1 ENSMUST00000030306.14 hook microtubule tethering protein 1 (from RefSeq NM_030014.2) ENSMUST00000030306.1 ENSMUST00000030306.10 ENSMUST00000030306.11 ENSMUST00000030306.12 ENSMUST00000030306.13 ENSMUST00000030306.2 ENSMUST00000030306.3 ENSMUST00000030306.4 ENSMUST00000030306.5 ENSMUST00000030306.6 ENSMUST00000030306.7 ENSMUST00000030306.8 ENSMUST00000030306.9 HOOK1_MOUSE NM_030014 Q8BIL5 Q8BIZ2 Q8K0P1 Q8K454 Q9CTN6 uc008ttc.1 uc008ttc.2 uc008ttc.3 uc008ttc.4 Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (By similarity). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (PubMed:12075009). Self-associates (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3 (By similarity). Interacts directly with AKTIP/FTS, HOOK2 and HOOK3 (By similarity). Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16, VPS18, VPS39 and VPS41; these interactions may be indirect (By similarity). Interacts with CCDC181 (PubMed:28283191). Interacts (via coiled-coil region) with RIMBP3 (via C-terminus) (PubMed:19091768). Interacts with LRGUK (via guanylate kinase-like domain) (PubMed:28003339). Interacts with microtubules (By similarity). May interacts with CLN3 (By similarity). Interacts with AP4M1; the interaction is direct, mediates the interaction between FTS-Hook-FHIP (FHF) complex and AP-4 and the perinuclear distribution of AP-4 (By similarity). Q8BIL5; P18572: Bsg; NbExp=2; IntAct=EBI-4285715, EBI-772883; Cytoplasm Cytoplasm, cytoskeleton te=Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosomes, or mitochondria (PubMed:12075009). Often found in close association with microtubules (PubMed:12075009). Does not associate with the Golgi complex (PubMed:12075009). During spermiogenesis, it localizes to the manchette in spermatids from steps 8-10 (PubMed:12075009). It is also present between the microtubule manchette and the nucleus (PubMed:12075009). During manchette elongation, it is preferentially localized to the nuclear ring of the manchette, whereas the strong localization to the manchette decreases (PubMed:12075009). In more mature spermatids, while the manchette migrates posteriorly, it localizes to punctuates spots (PubMed:12075009). At later stages of spermatid differentiation, the punctuate expression pattern is found at both the attachment site and the proximal end of the elongated manchette (PubMed:12075009). In contrast, it is not present in mature spermatozoa (PubMed:12075009). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BIL5-1; Sequence=Displayed; Name=2; Synonyms=sv; IsoId=Q8BIL5-2; Sequence=VSP_009340, VSP_009341; Mainly expressed in testis. Note=Defects in Hook1 are the cause of the azh (abnormal spermatozoon head shape) mutant phenotype, which induces spermatozoa with highly abnormal head morphology that differs drastically from the compact and hook-shaped head of the normal sperm, leading to a strong decrease of fertility. Belongs to the hook family. Sequence=AAH30877.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; actin binding protein binding cytoplasm centrosome cytosol cytoskeleton microtubule Golgi organization endosome organization lysosome organization multicellular organism development spermatogenesis spermatid development microtubule binding endosome to lysosome transport protein transport microtubule cytoskeleton cell differentiation cytoskeleton-dependent intracellular transport HOPS complex cytoplasmic microtubule organization identical protein binding early endosome to late endosome transport dynein light intermediate chain binding FHF complex manchette assembly uc008ttc.1 uc008ttc.2 uc008ttc.3 uc008ttc.4 
ENSMUST00000030309.6 Eqtn ENSMUST00000030309.6 equatorin, sperm acrosome associated, transcript variant 1 (from RefSeq NM_027089.4) A2AJE0 Afaf ENSMUST00000030309.1 ENSMUST00000030309.2 ENSMUST00000030309.3 ENSMUST00000030309.4 ENSMUST00000030309.5 EQTN_MOUSE Mn9 NM_027089 Q2LCV5 Q5FWB0 Q9D9V2 uc008tsm.1 uc008tsm.2 uc008tsm.3 uc008tsm.4 Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. Interacts with SNAP25. [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane; Single-pass type I membrane protein. Note=In the anterior acrosome region, enriched on the inner acrosomal membrane but minimal on the outer acrosomal membrane; in contrast in the posterior acrosome region enriched on both the inner and outer acrosomal membranes. [Isoform 2]: Nucleus. Cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D9V2-1; Sequence=Displayed; Name=2; IsoId=Q9D9V2-2; Sequence=VSP_025111; Sperm specific, including germ cells (at protein level). Highly N- and O-glycosylated; contains sialic acid. MN9 epitope is O-glycosylated. acrosome assembly inner acrosomal membrane acrosomal membrane outer acrosomal membrane protein binding nucleus cytoplasm early endosome plasma membrane endocytosis fusion of sperm to egg plasma membrane membrane integral component of membrane cytoplasmic vesicle acrosomal vesicle exocytosis uc008tsm.1 uc008tsm.2 uc008tsm.3 uc008tsm.4 
ENSMUST00000030311.11 Ift74 ENSMUST00000030311.11 intraflagellar transport 74, transcript variant 1 (from RefSeq NM_026319.3) B1AWG2 Ccdc2 Cmg1 ENSMUST00000030311.1 ENSMUST00000030311.10 ENSMUST00000030311.2 ENSMUST00000030311.3 ENSMUST00000030311.4 ENSMUST00000030311.5 ENSMUST00000030311.6 ENSMUST00000030311.7 ENSMUST00000030311.8 ENSMUST00000030311.9 IFT74_MOUSE NM_026319 Q80ZI3 Q8BKE9 Q9CSY1 Q9CUS0 Q9D9T5 uc008tsg.1 uc008tsg.2 uc008tsg.3 uc008tsg.4 Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis (By similarity). Essential for flagellogenesis during spermatogenesis (PubMed:31004481). Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (PubMed:16775004, PubMed:23810713). Interacts with IFT81; the interaction is direct: within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium. Interacts (via basic region) with beta-tubulin (via acidic region); interaction is direct. Interacts with ARL13B and IFT88. Interacts (via the IFT74/IFT81 heterodimer) with RABL2B (By similarity). Interacts with IFT57 and IFT70B (PubMed:23810713). Cell projection, cilium Cytoplasmic vesicle Cell projection, cilium, flagellum Cytoplasmic vesicle, secretory vesicle, acrosome Note=In male germ cells, strongly expressed in the vesicles of spermatocytes and round spermatids and also in the acrosome and centrosome regions of elongating spermatids and in developing sperm tails. Predominantly expressed in testis, but also detected in other organs containing cilia-bearing cells, including lung, brain and kidney (at protein level). In testis, expression starts at day 12 and strongly increases on day 20 and thereafter, temporally correlating with the first wave of spermatogenesis. Belongs to the IFT74 family. Sequence=BAB24617.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; keratinocyte development chromatin binding nucleus centrosome cilium Notch signaling pathway determination of left/right symmetry heart development epidermis development cell projection organization intraciliary transport particle B cytoplasmic vesicle positive regulation of cell adhesion mediated by integrin intraciliary transport involved in cilium assembly intraciliary transport cell projection positive regulation of transcription from RNA polymerase II promoter beta-tubulin binding negative regulation of epithelial cell proliferation cilium assembly non-motile cilium assembly uc008tsg.1 uc008tsg.2 uc008tsg.3 uc008tsg.4 
ENSMUST00000030313.9 Caap1 ENSMUST00000030313.9 caspase activity and apoptosis inhibitor 1, transcript variant 6 (from RefSeq NR_176047.1) CAAP1_MOUSE Caap ENSMUST00000030313.1 ENSMUST00000030313.2 ENSMUST00000030313.3 ENSMUST00000030313.4 ENSMUST00000030313.5 ENSMUST00000030313.6 ENSMUST00000030313.7 ENSMUST00000030313.8 NR_176047 Q3USG8 Q8VDY9 uc008tsa.1 uc008tsa.2 uc008tsa.3 uc008tsa.4 Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. molecular_function cellular_component apoptotic process regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway uc008tsa.1 uc008tsa.2 uc008tsa.3 uc008tsa.4 
ENSMUST00000030320.13 Cc2d1b ENSMUST00000030320.13 coiled-coil and C2 domain containing 1B (from RefSeq NM_177045.3) B2RQ40 C2D1B_MOUSE ENSMUST00000030320.1 ENSMUST00000030320.10 ENSMUST00000030320.11 ENSMUST00000030320.12 ENSMUST00000030320.2 ENSMUST00000030320.3 ENSMUST00000030320.4 ENSMUST00000030320.5 ENSMUST00000030320.6 ENSMUST00000030320.7 ENSMUST00000030320.8 ENSMUST00000030320.9 Kiaa1836 NM_177045 Q3UJ60 Q69Z95 Q8BRN9 uc008ubl.1 uc008ubl.2 uc008ubl.3 Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. Nucleus Belongs to the CC2D1 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleus nucleoplasm intracellular membrane-bounded organelle uc008ubl.1 uc008ubl.2 uc008ubl.3 
ENSMUST00000030323.3 Cfap107 ENSMUST00000030323.3 cilia and flagella associated protein 107 (from RefSeq NM_027056.1) A2A7Z7 CF107_MOUSE Cfap107 ENSMUST00000030323.1 ENSMUST00000030323.2 NM_027056 Q08EE4 Q4KKZ1 Q9DAD4 uc008vrf.1 uc008vrf.2 uc008vrf.3 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Cytoplasm, cytoskeleton, cilium axoneme Sequence=AAH99569.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI16373.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI26972.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component biological_process uc008vrf.1 uc008vrf.2 uc008vrf.3 
ENSMUST00000030326.10 Pramel13 ENSMUST00000030326.10 PRAME like 13 (from RefSeq NM_029948.2) B1ARV8 ENSMUST00000030326.1 ENSMUST00000030326.2 ENSMUST00000030326.3 ENSMUST00000030326.4 ENSMUST00000030326.5 ENSMUST00000030326.6 ENSMUST00000030326.7 ENSMUST00000030326.8 ENSMUST00000030326.9 NM_029948 Pramef12 Pramel13 Q9D2F1 Q9D2F1_MOUSE uc008vrd.1 uc008vrd.2 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vrd.1 uc008vrd.2 
ENSMUST00000030328.3 Aadacl4fm1 ENSMUST00000030328.3 AADACL4 family member 1 (from RefSeq NM_198662.3) A2A751 AD4F1_MOUSE Aadacl4fm1 ENSMUST00000030328.1 ENSMUST00000030328.2 NM_198662 Q8BM81 uc008vrh.1 uc008vrh.2 Membrane ; Single-pass membrane protein Belongs to the 'GDXG' lipolytic enzyme family. Sequence=BAC28757.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; cellular_component catabolic process membrane integral component of membrane hydrolase activity short-chain carboxylesterase activity uc008vrh.1 uc008vrh.2 
ENSMUST00000030332.7 Gpx7 ENSMUST00000030332.7 glutathione peroxidase 7 (from RefSeq NM_024198.3) ENSMUST00000030332.1 ENSMUST00000030332.2 ENSMUST00000030332.3 ENSMUST00000030332.4 ENSMUST00000030332.5 ENSMUST00000030332.6 GPX7_MOUSE NM_024198 Q99LJ6 uc008ubc.1 uc008ubc.2 uc008ubc.3 It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxygen species (ROS) and protects against oxidative DNA damage and double-strand breaks (By similarity). Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; Secreted Belongs to the glutathione peroxidase family. catalase activity peroxidase activity glutathione peroxidase activity extracellular region endoplasmic reticulum response to oxidative stress oxidoreductase activity oxidation-reduction process cellular oxidant detoxification uc008ubc.1 uc008ubc.2 uc008ubc.3 
ENSMUST00000030336.11 Tnfrsf1b ENSMUST00000030336.11 tumor necrosis factor receptor superfamily, member 1b (from RefSeq NM_011610.3) ENSMUST00000030336.1 ENSMUST00000030336.10 ENSMUST00000030336.2 ENSMUST00000030336.3 ENSMUST00000030336.4 ENSMUST00000030336.5 ENSMUST00000030336.6 ENSMUST00000030336.7 ENSMUST00000030336.8 ENSMUST00000030336.9 NM_011610 Q545P4 Q545P4_MOUSE Tnfrsf1b uc008vrt.1 uc008vrt.2 uc008vrt.3 Lacks conserved residue(s) required for the propagation of feature annotation. tumor necrosis factor-activated receptor activity nucleus inflammatory response immune response aging membrane integral component of membrane axon ubiquitin protein ligase binding response to lipopolysaccharide tumor necrosis factor-mediated signaling pathway neuronal cell body tumor necrosis factor binding varicosity membrane raft perinuclear region of cytoplasm positive regulation of membrane protein ectodomain proteolysis cellular response to lipopolysaccharide cellular response to tumor necrosis factor cellular response to growth factor stimulus uc008vrt.1 uc008vrt.2 uc008vrt.3 
ENSMUST00000030339.13 Tnfrsf8 ENSMUST00000030339.13 tumor necrosis factor receptor superfamily, member 8 (from RefSeq NM_009401.3) A1L3C9 ENSMUST00000030339.1 ENSMUST00000030339.10 ENSMUST00000030339.11 ENSMUST00000030339.12 ENSMUST00000030339.2 ENSMUST00000030339.3 ENSMUST00000030339.4 ENSMUST00000030339.5 ENSMUST00000030339.6 ENSMUST00000030339.7 ENSMUST00000030339.8 ENSMUST00000030339.9 NM_009401 Q60846 TNR8_MOUSE Tnfrsf8 uc008vrv.1 uc008vrv.2 uc008vrv.3 Receptor for TNFSF8/CD30L (PubMed:8543792). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa- B (By similarity). Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. Cell membrane ; Single-pass type I membrane protein Detected in thymus and in activated splenocytes. By concanavalin A and pokeweed mitogen in splenocytes. Belongs to the TNFR8 family. transmembrane signaling receptor activity plasma membrane signal transduction membrane integral component of membrane positive regulation of tumor necrosis factor biosynthetic process positive regulation of apoptotic process positive regulation of TRAIL biosynthetic process positive regulation of NF-kappaB transcription factor activity uc008vrv.1 uc008vrv.2 uc008vrv.3 
ENSMUST00000030340.15 Scp2 ENSMUST00000030340.15 sterol carrier protein 2, liver (from RefSeq NM_011327.4) A2APS2 A2APS3 ENSMUST00000030340.1 ENSMUST00000030340.10 ENSMUST00000030340.11 ENSMUST00000030340.12 ENSMUST00000030340.13 ENSMUST00000030340.14 ENSMUST00000030340.2 ENSMUST00000030340.3 ENSMUST00000030340.4 ENSMUST00000030340.5 ENSMUST00000030340.6 ENSMUST00000030340.7 ENSMUST00000030340.8 ENSMUST00000030340.9 NM_011327 P32020 Q9DBM7 SCP2_MOUSE Scp-2 Scp2 uc008uas.1 uc008uas.2 uc008uas.3 uc008uas.4 [Isoform SCPx]: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:10706581). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:10706581). Also active with medium and long straight chain 3-oxoacyl-CoAs (By similarity). Stimulates the microsomal conversion of 7- dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048). [Isoform SCP2]: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA (PubMed:9553048). Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides (PubMed:11003606). Seems to stimulate the rate- limiting step in phosphatidic acid formation mediated by GPAT3 (PubMed:11003606). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048). [Isoform SCPx]: Reaction=choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha- trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA; Xref=Rhea:RHEA:16865, ChEBI:CHEBI:57287, ChEBI:CHEBI:57373, ChEBI:CHEBI:57392, ChEBI:CHEBI:58507; EC=2.3.1.176; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:16867; Evidence=; [Isoform SCPx]: Reaction=4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3- oxopristanoyl-CoA + CoA; Xref=Rhea:RHEA:10408, ChEBI:CHEBI:57287, ChEBI:CHEBI:57291, ChEBI:CHEBI:57351, ChEBI:CHEBI:57392; EC=2.3.1.176; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:10410; Evidence=; Reaction=acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA; Xref=Rhea:RHEA:21564, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58342, ChEBI:CHEBI:90726; EC=2.3.1.16; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21566; Evidence=; [Isoform SCPx]: Reaction=acetyl-CoA + hexanoyl-CoA = 3-oxooctanoyl-CoA + CoA; Xref=Rhea:RHEA:31203, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:62619, ChEBI:CHEBI:62620; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31205; Evidence=; [Isoform SCPx]: Reaction=acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA; Xref=Rhea:RHEA:18161, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57349, ChEBI:CHEBI:57385; EC=2.3.1.155; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18163; Evidence=; [Isoform SCPx]: Reaction=3-oxohexadecanedioyl-CoA + CoA = acetyl-CoA + tetradecanedioyl-CoA; Xref=Rhea:RHEA:40343, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:77081, ChEBI:CHEBI:77084; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40344; Evidence=; [Isoform SCPx]: Reaction=propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2- methylhexadecanoyl-CoA + CoA; Xref=Rhea:RHEA:46344, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:57392, ChEBI:CHEBI:86042; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:46346; Evidence=; [Isoform SCPx]: Reaction=acetyl-CoA + butanoyl-CoA = 3-oxohexanoyl-CoA + CoA; Xref=Rhea:RHEA:31111, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57371, ChEBI:CHEBI:62418; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31113; Evidence=; [Isoform SCPx]: Reaction=acetyl-CoA + octanoyl-CoA = 3-oxodecanoyl-CoA + CoA; Xref=Rhea:RHEA:31087, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57386, ChEBI:CHEBI:62548; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31089; Evidence=; [Isoform SCPx]: Reaction=acetyl-CoA + decanoyl-CoA = 3-oxododecanoyl-CoA + CoA; Xref=Rhea:RHEA:31183, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61430, ChEBI:CHEBI:62615; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31185; Evidence=; [Isoform SCPx]: Reaction=acetyl-CoA + dodecanoyl-CoA = 3-oxotetradecanoyl-CoA + CoA; Xref=Rhea:RHEA:31091, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57375, ChEBI:CHEBI:62543; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31093; Evidence=; [Isoform SCPx]: Reaction=acetyl-CoA + hexadecanoyl-CoA = 3-oxooctadecanoyl-CoA + CoA; Xref=Rhea:RHEA:35279, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57379, ChEBI:CHEBI:71407; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:35281; Evidence=; [Isoform SCPx]: Reaction=3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA; Xref=Rhea:RHEA:47400, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:87695, ChEBI:CHEBI:87698; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47401; Evidence=; [Isoform SCPx]: Reaction=7-dehydrocholesterol(in) = 7-dehydrocholesterol(out); Xref=Rhea:RHEA:62960, ChEBI:CHEBI:17759; Evidence=; [Isoform SCP2]: Reaction=7-dehydrocholesterol(in) = 7-dehydrocholesterol(out); Xref=Rhea:RHEA:62960, ChEBI:CHEBI:17759; Evidence=; [Isoform SCP2]: Interacts with PEX5; the interaction is essential for peroxisomal import. [Isoform SCP2]: Cytoplasm Peroxisome Endoplasmic reticulum Mitochondrion [Isoform SCPx]: Peroxisome Event=Alternative initiation; Named isoforms=2; Name=SCPx; IsoId=P32020-1; Sequence=Displayed; Name=SCP2; IsoId=P32020-2; Sequence=VSP_018895; Present at low levels in all tissues examined but expressed predominantly in the liver. [Isoform SCPx]: In testis, highly expressed in the interstitial connective tissue, an area rich in interstitial cells of Leydig, but it is barely expressed in the germ cells of the seminiferous tubule. [Isoform SCP2]: In testis, expressed in the interstitial connective tissue, an area rich in interstitial cells of Leydig at lower levels than isoform SCPx. [Isoform SCP2]: preSCP2, a protein with a molecular mass of about 15 kDa, is processed into its mature form (SCP2) by proteolytic cleavage of a 20 residue leader sequence after translocation into peroxisomes. Knockouts are viable and fertile (PubMed:9553048). Mutants show alterations in hepatic gene expression, peroxisome proliferation, hypolipidemia, impaired body weight control and neuropathy (PubMed:9553048). [Isoform SCP2]: Contains a putative mitochondrial transit peptide at positions 1-20. In the N-terminal section; belongs to the thiolase-like superfamily. Thiolase family. fatty-acyl-CoA binding catalytic activity acetyl-CoA C-acyltransferase activity receptor binding protein binding nucleus nucleoplasm cytoplasm mitochondrion peroxisome peroxisomal matrix endoplasmic reticulum cytosol acyl-CoA metabolic process steroid biosynthetic process progesterone biosynthetic process lipid transport peroxisome organization aging lipid binding phosphatidylcholine transporter activity phosphatidylinositol transporter activity positive regulation of steroid biosynthetic process cholesterol binding phospholipid transport sterol transport membrane transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups extrinsic component of membrane extrinsic component of mitochondrial outer membrane positive regulation of intracellular cholesterol transport inositol trisphosphate biosynthetic process macromolecular complex propanoyl-CoA C-acyltransferase activity long-chain fatty acyl-CoA binding protein homodimerization activity positive regulation of apoptotic process intracellular membrane-bounded organelle positive regulation of cholesterol biosynthetic process positive regulation of steroid metabolic process protein heterodimerization activity propionyl-CoA C2-trimethyltridecanoyltransferase activity oleic acid binding protein localization to plasma membrane lipid hydroperoxide transport positive regulation of cholesterol import phosphatidylethanolamine transporter activity uc008uas.1 uc008uas.2 uc008uas.3 uc008uas.4 
ENSMUST00000030345.15 Cpt2 ENSMUST00000030345.15 carnitine palmitoyltransferase 2 (from RefSeq NM_009949.2) CPT2_MOUSE Cpt-2 Cpt2 ENSMUST00000030345.1 ENSMUST00000030345.10 ENSMUST00000030345.11 ENSMUST00000030345.12 ENSMUST00000030345.13 ENSMUST00000030345.14 ENSMUST00000030345.2 ENSMUST00000030345.3 ENSMUST00000030345.4 ENSMUST00000030345.5 ENSMUST00000030345.6 ENSMUST00000030345.7 ENSMUST00000030345.8 ENSMUST00000030345.9 NM_009949 P52825 Q3TFS0 uc008uan.1 uc008uan.2 uc008uan.3 uc008uan.4 Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters. Reaction=(R)-carnitine + hexadecanoyl-CoA = CoA + O-hexadecanoyl-(R)- carnitine; Xref=Rhea:RHEA:12661, ChEBI:CHEBI:16347, ChEBI:CHEBI:17490, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=2.3.1.21; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:12663; Evidence=; Reaction=(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine; Xref=Rhea:RHEA:17177, ChEBI:CHEBI:16347, ChEBI:CHEBI:18102, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386; Evidence=; Reaction=(R)-carnitine + decanoyl-CoA = CoA + O-decanoyl-(R)-carnitine; Xref=Rhea:RHEA:44828, ChEBI:CHEBI:16347, ChEBI:CHEBI:28717, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence=; Reaction=(R)-carnitine + dodecanoyl-CoA = CoA + O-dodecanoyl-R- carnitine; Xref=Rhea:RHEA:40279, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:77086; Evidence=; Reaction=(R)-carnitine + tetradecanoyl-CoA = CoA + O-tetradecanoyl-(R)- carnitine; Xref=Rhea:RHEA:44832, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:84634; Evidence=; Reaction=(R)-carnitine + octadecanoyl-CoA = CoA + O-octadecanoyl-(R)- carnitine; Xref=Rhea:RHEA:44840, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:84644; Evidence=; Reaction=(R)-carnitine + eicosanoyl-CoA = CoA + O-eicosanoyl-(R)- carnitine; Xref=Rhea:RHEA:44844, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:84645; Evidence=; Reaction=(9Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)- tetradecenoyl-(R)-carnitine; Xref=Rhea:RHEA:44848, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:65060, ChEBI:CHEBI:84647; Evidence=; Reaction=(5Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(5Z)- tetradecenoyl-(R)-carnitine; Xref=Rhea:RHEA:44852, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:84649, ChEBI:CHEBI:84650; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)- octadecenoyl-(R)-carnitine; Xref=Rhea:RHEA:44856, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:84651; Evidence=; Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8- dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061, ChEBI:CHEBI:84654; Evidence=; Lipid metabolism; fatty acid beta-oxidation. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the carnitine/choline acetyltransferase family. in utero embryonic development carnitine O-palmitoyltransferase activity nucleoplasm nucleolus mitochondrion mitochondrial inner membrane lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation membrane transferase activity transferase activity, transferring acyl groups uc008uan.1 uc008uan.2 uc008uan.3 uc008uan.4 
ENSMUST00000030348.6 Magoh ENSMUST00000030348.6 mago homolog, exon junction complex core component (from RefSeq NM_001282737.1) A2A8E0 ENSMUST00000030348.1 ENSMUST00000030348.2 ENSMUST00000030348.3 ENSMUST00000030348.4 ENSMUST00000030348.5 MGN_MOUSE NM_001282737 O35169 P50606 P61327 uc008uaj.1 uc008uaj.2 uc008uaj.3 Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Heterodimer with RBM8A. Core component of the mRNA splicing- dependent exon junction complex (EJC); the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A. Interacts with PYM1; the interaction is direct and dissociates the EJC from spliced mRNAs. Identified in a complex composed of the EJC core, UPF3B and UPF2. The EJC core can also interact with UPF3A (in vitro). Identified in the spliceosome C complex. Nucleus Nucleus speckle Cytoplasm Note=Detected in granule-like structures in the dendroplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. Ubiquitous. Detected in brain, heart, liver, lung, spleen and testis. Belongs to the mago nashi family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of alternative mRNA splicing, via spliceosome RNA binding nucleus spliceosomal complex cytoplasm mRNA processing regulation of translation female gamete generation RNA splicing nuclear speck exon-exon junction complex mRNA transport catalytic step 2 spliceosome uc008uaj.1 uc008uaj.2 uc008uaj.3 
ENSMUST00000030360.11 Lrrc42 ENSMUST00000030360.11 leucine rich repeat containing 42 (from RefSeq NM_029985.2) ENSMUST00000030360.1 ENSMUST00000030360.10 ENSMUST00000030360.2 ENSMUST00000030360.3 ENSMUST00000030360.4 ENSMUST00000030360.5 ENSMUST00000030360.6 ENSMUST00000030360.7 ENSMUST00000030360.8 ENSMUST00000030360.9 LRC42_MOUSE NM_029985 Q3TE62 Q8R2U7 Q9CTP9 uc008tzm.1 uc008tzm.2 uc008tzm.3 Belongs to the LRRC42 family. Sequence=BAE41386.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc008tzm.1 uc008tzm.2 uc008tzm.3 
ENSMUST00000030361.11 Tmem59 ENSMUST00000030361.11 transmembrane protein 59 (from RefSeq NM_029565.3) ENSMUST00000030361.1 ENSMUST00000030361.10 ENSMUST00000030361.2 ENSMUST00000030361.3 ENSMUST00000030361.4 ENSMUST00000030361.5 ENSMUST00000030361.6 ENSMUST00000030361.7 ENSMUST00000030361.8 ENSMUST00000030361.9 NM_029565 ORF18 Q3TWB4 Q99LY8 Q9D1P9 Q9QY73 TMM59_MOUSE Tdcf1 uc008tzj.1 uc008tzj.2 uc008tzj.3 uc008tzj.4 Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. Interacts with ATG16L1 (via WD repeats). Late endosome membrane ; Single-pass type I membrane protein Lysosome membrane ; Single-pass type I membrane protein Cell membrane ; Single-pass type I membrane protein Golgi apparatus membrane ; Single-pass type I membrane protein Note=Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded. The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy. N-glycosylated. Belongs to the TMEM59 family. Golgi cis cisterna Golgi trans cisterna Golgi membrane endopeptidase activity lysosome lysosomal membrane endosome late endosome Golgi apparatus Golgi medial cisterna plasma membrane proteolysis autophagy positive regulation of autophagy negative regulation of protein processing membrane integral component of membrane late endosome membrane negative regulation of protein glycosylation in Golgi negative regulation of protein localization to plasma membrane uc008tzj.1 uc008tzj.2 uc008tzj.3 uc008tzj.4 
ENSMUST00000030365.6 Mrpl37 ENSMUST00000030365.6 mitochondrial ribosomal protein L37 (from RefSeq NM_025500.2) ENSMUST00000030365.1 ENSMUST00000030365.2 ENSMUST00000030365.3 ENSMUST00000030365.4 ENSMUST00000030365.5 NM_025500 Q921S7 RM37_MOUSE uc008tza.1 uc008tza.2 uc008tza.3 uc008tza.4 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mL37 family. structural constituent of ribosome mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit ribosome translation biological_process uc008tza.1 uc008tza.2 uc008tza.3 uc008tza.4 
ENSMUST00000030367.15 Ssbp3 ENSMUST00000030367.15 single-stranded DNA binding protein 3, transcript variant 1 (from RefSeq NM_023672.2) ENSMUST00000030367.1 ENSMUST00000030367.10 ENSMUST00000030367.11 ENSMUST00000030367.12 ENSMUST00000030367.13 ENSMUST00000030367.14 ENSMUST00000030367.2 ENSMUST00000030367.3 ENSMUST00000030367.4 ENSMUST00000030367.5 ENSMUST00000030367.6 ENSMUST00000030367.7 ENSMUST00000030367.8 ENSMUST00000030367.9 Last NM_023672 Q99LC6 Q9D032 Q9EQP3 SSBP3_MOUSE Ssdp1 uc008tyx.1 uc008tyx.2 This gene encodes a member of the Ssdp (sequence-specific single-stranded DNA binding protein) family of proteins. The encoded protein binds specifically to single-stranded pyrimidine-rich DNA elements. The encoded protein has been shown to be important for head development and may play a role in the differentiation of spinal interneurons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D032-1; Sequence=Displayed; Name=2; IsoId=Q9D032-2; Sequence=VSP_006262; hematopoietic progenitor cell differentiation DNA binding single-stranded DNA binding protein binding nucleus transcription factor complex positive regulation of cell proliferation prechordal plate formation midbrain-hindbrain boundary initiation macromolecular complex positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter mesendoderm development head development head morphogenesis macromolecular complex assembly positive regulation of anterior head development uc008tyx.1 uc008tyx.2 
ENSMUST00000030372.6 Col9a2 ENSMUST00000030372.6 collagen, type IX, alpha 2 (from RefSeq NM_007741.2) Col9a2 ENSMUST00000030372.1 ENSMUST00000030372.2 ENSMUST00000030372.3 ENSMUST00000030372.4 ENSMUST00000030372.5 I7HJR1 I7HJR1_MOUSE NM_007741 uc008unx.1 uc008unx.2 uc008unx.3 uc008unx.4 collagen type IX trimer uc008unx.1 uc008unx.2 uc008unx.3 uc008unx.4 
ENSMUST00000030375.9 Exo5 ENSMUST00000030375.9 exonuclease 5, transcript variant 1 (from RefSeq NM_028457.2) A2A767 A2A769 Dem1 ENSMUST00000030375.1 ENSMUST00000030375.2 ENSMUST00000030375.3 ENSMUST00000030375.4 ENSMUST00000030375.5 ENSMUST00000030375.6 ENSMUST00000030375.7 ENSMUST00000030375.8 EXO5_MOUSE NM_028457 Q9CXP9 uc008unt.1 uc008unt.2 uc008unt.3 Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'- directionality activity (By similarity). Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Monomer; monomeric form has weak exonuclease activity. Homodimer; homodimeric form is unsure but has much higher exonuclease activity, suggesting that it could homodimerize upon DNA-binding. Interacts with the replication protein A (RPA) complex (By similarity). Nucleus Cytoplasm, cytosol Note=Localizes to repair foci in response to DNA damage. Belongs to the EXO5 family. Sequence=CAM16720.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM16722.1; Type=Erroneous gene model prediction; Evidence=; DNA binding nuclease activity exonuclease activity nucleus nucleoplasm cytoplasm cytosol DNA repair cellular response to DNA damage stimulus hydrolase activity interstrand cross-link repair single-stranded DNA 5'-3' exodeoxyribonuclease activity metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding nucleic acid phosphodiester bond hydrolysis uc008unt.1 uc008unt.2 uc008unt.3 
ENSMUST00000030376.8 Kcnq4 ENSMUST00000030376.8 potassium voltage-gated channel, subfamily Q, member 4, transcript variant 3 (from RefSeq NM_001425005.1) A2A7E8 ENSMUST00000030376.1 ENSMUST00000030376.2 ENSMUST00000030376.3 ENSMUST00000030376.4 ENSMUST00000030376.5 ENSMUST00000030376.6 ENSMUST00000030376.7 KCNQ4_MOUSE NM_001425005 Q8C9Y6 Q9JK97 uc008unm.1 uc008unm.2 uc008unm.3 Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. Homotetramer. May form heteromultimers with KCNQ3 (By similarity). Interacts with HSP90AB1; promotes cell surface expression of KCNQ4 (By similarity). Basal cell membrane; Multi-pass membrane protein. Note=Situated at the basal membrane of cochlear outer hair cells. In the inner ear expressed in the outer sensory hair cells of the cochlea and in type I hair cells of the vestibular organs. Also expressed in the postsynaptic membrane of the calyx nerve endings innervating type I cells. In the brain expressed in neurons of many, but not all, nuclei of the central auditory pathway. Absent from most other brain regions. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The A-domain tail carries the major determinants of channel assembly specificity. Its coiled-coil region is Four-stranded (By similarity). Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity calmodulin binding cytoplasm plasma membrane ion transport potassium ion transport sensory perception of sound voltage-gated potassium channel complex basal plasma membrane membrane integral component of membrane negative regulation of synaptic transmission, dopaminergic regulation of ion transmembrane transport inner ear morphogenesis neuron projection transmembrane transport potassium ion transmembrane transport uc008unm.1 uc008unm.2 uc008unm.3 
ENSMUST00000030381.8 Ctps1 ENSMUST00000030381.8 cytidine 5'-triphosphate synthase 1, transcript variant 1 (from RefSeq NM_016748.2) Ctps ENSMUST00000030381.1 ENSMUST00000030381.2 ENSMUST00000030381.3 ENSMUST00000030381.4 ENSMUST00000030381.5 ENSMUST00000030381.6 ENSMUST00000030381.7 NM_016748 P70698 PYRG1_MOUSE Q922Y4 uc008unj.1 uc008unj.2 uc008unj.3 This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. Reaction=ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L- glutamate + phosphate; Xref=Rhea:RHEA:26426, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398, ChEBI:CHEBI:58359, ChEBI:CHEBI:456216; EC=6.3.4.2; Evidence=; Activated by GTP and inhibited by CTP. Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. Cytoplasm, cytosol Note=Mainly cytosolic but when active detected in long filamentous structures (By similarity). Co-localizes with TNK2 in the cytosolic filaments (PubMed:25223282). Belongs to the CTP synthase family. nucleotide binding immune system process CTP synthase activity ATP binding cytoplasm pyrimidine nucleotide biosynthetic process CTP biosynthetic process glutamine metabolic process ligase activity pyrimidine nucleobase biosynthetic process T cell proliferation B cell proliferation identical protein binding 'de novo' CTP biosynthetic process cytoophidium uc008unj.1 uc008unj.2 uc008unj.3 
ENSMUST00000030384.5 Edn2 ENSMUST00000030384.5 endothelin 2 (from RefSeq NM_007902.3) EDN2_MOUSE ENSMUST00000030384.1 ENSMUST00000030384.2 ENSMUST00000030384.3 ENSMUST00000030384.4 NM_007902 P22389 Q9JME3 uc008unb.1 uc008unb.2 uc008unb.3 This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a potent vasoconstrictive peptide. This gene is abundantly expressed in the gastrointestinal tract, strongly induced in photorecepteror cells in retinal diseases and injury, and produced by microglia and macrophages in the early stages of glaucoma. Mice lacking the encoded protein exhibit severe growth retardation, hypothermia and juvenile lethality. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC037042.1, X59556.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Vasoconstrictor. Secreted. Belongs to the endothelin/sarafotoxin family. prostaglandin biosynthetic process ovarian follicle rupture temperature homeostasis positive regulation of leukocyte chemotaxis regulation of systemic arterial blood pressure by endothelin hormone activity extracellular region extracellular space cell positive regulation of cytosolic calcium ion concentration protein kinase C-activating G-protein coupled receptor signaling pathway regulation of blood pressure positive regulation of cell proliferation positive regulation of heart rate artery smooth muscle contraction vein smooth muscle contraction cytokine-mediated signaling pathway regulation of vasoconstriction calcium-mediated signaling neutrophil chemotaxis endothelin B receptor binding macrophage activation vasoconstriction positive regulation of smooth muscle contraction positive regulation of hormone secretion negative regulation of hormone secretion inositol phosphate-mediated signaling macrophage chemotaxis lung alveolus development positive regulation of prostaglandin-endoperoxide synthase activity energy homeostasis uc008unb.1 uc008unb.2 uc008unb.3 
ENSMUST00000030385.13 Ppcs ENSMUST00000030385.13 phosphopantothenoylcysteine synthetase, transcript variant 1 (from RefSeq NM_026494.4) Coab ENSMUST00000030385.1 ENSMUST00000030385.10 ENSMUST00000030385.11 ENSMUST00000030385.12 ENSMUST00000030385.2 ENSMUST00000030385.3 ENSMUST00000030385.4 ENSMUST00000030385.5 ENSMUST00000030385.6 ENSMUST00000030385.7 ENSMUST00000030385.8 ENSMUST00000030385.9 NM_026494 PPCS_MOUSE Q3TVW0 Q8VDG5 Q9D376 Q9DA06 uc008umm.1 uc008umm.2 uc008umm.3 Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Has a preference for ATP over CTP as a cosubstrate. Reaction=(R)-4'-phosphopantothenate + ATP + L-cysteine = AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine; Xref=Rhea:RHEA:25156, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:35235, ChEBI:CHEBI:59458, ChEBI:CHEBI:456215; EC=6.3.2.51; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25157; Evidence=; Reaction=(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine; Xref=Rhea:RHEA:19397, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:35235, ChEBI:CHEBI:37563, ChEBI:CHEBI:59458, ChEBI:CHEBI:60377; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19398; Evidence=; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 2/5. Homodimer. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VDG5-1; Sequence=Displayed; Name=2; IsoId=Q8VDG5-2; Sequence=VSP_010244; The mammalian enzyme has a preference for ATP over CTP, in contrast to the E.coli ortholog. Belongs to the PPC synthetase family. heart process phosphopantothenate--cysteine ligase activity acetyl-CoA biosynthetic process coenzyme A biosynthetic process ligase activity protein homodimerization activity uc008umm.1 uc008umm.2 uc008umm.3 
ENSMUST00000030391.9 Tfap2c ENSMUST00000030391.9 transcription factor AP-2, gamma, transcript variant 1 (from RefSeq NM_009335.2) AP2C_MOUSE ENSMUST00000030391.1 ENSMUST00000030391.2 ENSMUST00000030391.3 ENSMUST00000030391.4 ENSMUST00000030391.5 ENSMUST00000030391.6 ENSMUST00000030391.7 ENSMUST00000030391.8 NM_009335 Q61312 Q99L72 Tcfap2c uc008ocz.1 uc008ocz.2 uc008ocz.3 uc008ocz.4 Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with UBE2I (By similarity). Interacts with CITED4. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Interacts with MTA1 (By similarity). Nucleus Expressed in lung, ovary and testis. Expressed in most squamous epithelia. Also, detected in several exocrine glands including the prostate, the preputial and salivary glands, serous glands of the tongue and ocular harderian glands. During retinoic acid-mediated differentiation. The PPxY motif mediates interaction with WWOX. Sumoylated on Lys-10; which inhibits transcriptional activity. Belongs to the AP-2 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding trophectodermal cell differentiation hair follicle development keratinocyte development DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm mitochondrion regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter stem cell population maintenance forebrain neuron fate commitment cerebral cortex development cell differentiation germ-line stem cell population maintenance somatic stem cell population maintenance regulation of gene expression, epigenetic skin development regulation of epidermis development positive regulation of transcription from RNA polymerase II promoter protein dimerization activity sebaceous gland development dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis epithelial cell proliferation involved in mammary gland duct elongation uc008ocz.1 uc008ocz.2 uc008ocz.3 uc008ocz.4 
ENSMUST00000030395.9 Svbp ENSMUST00000030395.9 small vasohibin binding protein, transcript variant 2 (from RefSeq NM_024462.2) Ccdc23 ENSMUST00000030395.1 ENSMUST00000030395.2 ENSMUST00000030395.3 ENSMUST00000030395.4 ENSMUST00000030395.5 ENSMUST00000030395.6 ENSMUST00000030395.7 ENSMUST00000030395.8 NM_024462 Q99LQ4 SVBP_MOUSE Svbp uc008ulk.1 uc008ulk.2 uc008ulk.3 uc008ulk.4 Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146868, PubMed:31363758, PubMed:35482892). Also required to enhance the solubility and secretion of VASH1 and VASH2 (By similarity). Plays a role in axon and excitatory synapse formation (PubMed:31235911). Interacts with VASH1 and VASH2. Cytoplasm Secreted Cytoplasm, cytoskeleton Note=Detected both intracellularly and extracellularly (PubMed:20736312). Within cells, localizes mainly to the apical part of the cell (PubMed:20736312). Highly expressed in bone marrow, spleen and testis. Mice display a significant reduction in whole brain volume, with a particular decrease in white matter (PubMed:31363758). Neurons show decreased, but not abolished, tubulin detyrosination, leading to an accumulation of tyrosinated tubulin. This causes delayed axonal differentiation and morphologically disturbed dendritic branching (PubMed:31363758). Mice show behavioral abnormalities, including increased activity and reduced social investigation (PubMed:31363758). Mice lacking both Matcap and Svbp are viable but show a reduction in brain volume: microcephaly is associated with proliferative defects during neurogenesis and abnormal behavior (PubMed:35482892). Cells lacking both Matcap and Svbp show abolished tubulin detyrosination (PubMed:35482892). Belongs to the SVBP family. protein binding extracellular region cytoplasm proteolysis protein secretion negative regulation of endothelial cell migration negative regulation of protein ubiquitination apical part of cell uc008ulk.1 uc008ulk.2 uc008ulk.3 uc008ulk.4 
ENSMUST00000030398.10 Slc2a1 ENSMUST00000030398.10 solute carrier family 2 (facilitated glucose transporter), member 1, transcript variant 1 (from RefSeq NM_011400.4) ENSMUST00000030398.1 ENSMUST00000030398.2 ENSMUST00000030398.3 ENSMUST00000030398.4 ENSMUST00000030398.5 ENSMUST00000030398.6 ENSMUST00000030398.7 ENSMUST00000030398.8 ENSMUST00000030398.9 GTR1_MOUSE Glut1 NM_011400 P17809 Q61608 Q6GTI3 Slc2a1 uc008ule.1 uc008ule.2 uc008ule.3 uc008ule.4 uc008ule.5 Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:17320047, PubMed:35810171). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (PubMed:35810171). Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, ChEBI:CHEBI:4167; Evidence=; The uptake of glucose is inhibited by cytochalasin B. Glucose uptake is increased in response to phorbol ester 12-O- tetradecanoylphorbol-13-acetate (TPA) treatment: TPA-induced glucose uptake requires phosphorylation at Ser-226. Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN isoform 2. Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with GIPC (via PDZ domain). Interacts with STOM. Interacts with SGTA (via Gln-rich region) (By similarity). Interacts with isoform 1 of BSG (By similarity). Interacts with SMIM43; the interaction may promote SLC2A1-mediated glucose transport to meet the energy needs of mesendoderm differentiation (PubMed:35810171). P17809; A0A286YD83: Smim43; NbExp=5; IntAct=EBI-646060, EBI-46438951; Cell membrane ulti-pass membrane protein Photoreceptor inner segment Retina (at protein level). Levels decline 3-fold between days 7.5 and 12.5 of gestation. At 7.5 dpc, expressed more strongly in extraembryonic tissues than in the embryo proper. Expressed in amnion, chorion, and ectoplacental cone. In the yolk sac, expressed more strongly in the mesoderm layer than the ectoderm. Expression fairly widespread in the embryo at 8.5 dpc, but by 10.5 dpc, expression is down-regulated and observed in the eye and the spinal cord. Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization. Early embryonic lethality. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. response to hypoxia female pronucleus glucose transmembrane transporter activity protein binding cytoplasm cytosol plasma membrane integral component of plasma membrane caveola cell-cell junction response to osmotic stress female pregnancy carbohydrate transport intercalated disc membrane integral component of membrane basolateral plasma membrane apical plasma membrane kinase binding cerebral cortex development transmembrane transporter activity Z disc midbody cortical actin cytoskeleton vesicle response to insulin dehydroascorbic acid transporter activity cellular response to glucose starvation sarcolemma identical protein binding xenobiotic transport xenobiotic transporter activity protein self-association membrane raft D-glucose transmembrane transporter activity transmembrane transport macromolecular complex assembly dehydroascorbic acid transport cellular response to mechanical stimulus cellular hyperosmotic response response to Thyroglobulin triiodothyronine glucose transmembrane transport uc008ule.1 uc008ule.2 uc008ule.3 uc008ule.4 uc008ule.5 
ENSMUST00000030399.7 Rragc ENSMUST00000030399.7 Ras-related GTP binding C (from RefSeq NM_017475.2) A2A7K7 ENSMUST00000030399.1 ENSMUST00000030399.2 ENSMUST00000030399.3 ENSMUST00000030399.4 ENSMUST00000030399.5 ENSMUST00000030399.6 NM_017475 Q3TL69 Q6IQZ6 Q8CFT7 Q99K70 Q9Z124 RRAGC_MOUSE Rragc uc008uqm.1 uc008uqm.2 uc008uqm.3 Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP- bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB). In its GDP- bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the MTOR signaling cascade by amino acids. Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; The activation of RagC/RRAGC is mediated by a GTPase activating protein (GAP) (By similarity). In high-amino acid conditions, activated by GTPase activating protein FLCN that stimulates RRAGC GTPase activity to turn it into its active GDP-bound form (By similarity). In response to amino acid depletion, the GATOR1 complex inactivates RagC/RRAGC by securing the GTP-bound inactive form (By similarity). Forms a heterodimer with RRAGA, in a sequence-independent manner, and RRAGB (By similarity). Heterodimerization stabilizes proteins of the heterodimer (By similarity). The GDP-bound form of RRAGC (in complex with the GTP-bound form of RRAGA or RRAGB), interacts with RPTOR, thereby promoting recruitment of mTORC1 to the lysosomes (By similarity). Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator (By similarity). Interacts with NOL8 (By similarity). Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR (By similarity). The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor (By similarity). Interacts with SESN1, SESN2 and SESN3 (PubMed:25259925). Interacts with PIP4P1 (PubMed:29644770). The GDP-bound form interacts with TFEB (By similarity). The GDP-bound form interacts with TFE3 (PubMed:30595499). Cytoplasm Nucleus Lysosome membrane Note=Predominantly cytoplasmic. Recruited to the lysosome surface by the Ragulator complex. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q99K70-1; Sequence=Displayed; Name=2 ; IsoId=Q99K70-2; Sequence=VSP_052076, VSP_052077; Expressed most abundantly in kidney. Moderately expressed in brain, ovary, and testis, and detected at lower levels in heart, liver, and muscle. Not detected in lung, spleen, and small intestine. Widely expressed in tumor cells, with expression being specifically up-regulated in highly metastatic cells. Belongs to the GTR/RAG GTP-binding protein family. Sequence=BAA75671.1; Type=Frameshift; Evidence=; nucleotide binding GTPase activity protein binding GTP binding nucleus cytoplasm lysosome cellular response to starvation regulation of autophagy GDP binding regulation of TOR signaling positive regulation of TOR signaling cellular response to amino acid starvation EGO complex response to amino acid intracellular membrane-bounded organelle protein heterodimerization activity GTPase binding cellular response to amino acid stimulus regulation of TORC1 signaling Gtr1-Gtr2 GTPase complex uc008uqm.1 uc008uqm.2 uc008uqm.3 
ENSMUST00000030400.14 Mycbp ENSMUST00000030400.14 MYC binding protein (from RefSeq NM_019660.3) Amy1 ENSMUST00000030400.1 ENSMUST00000030400.10 ENSMUST00000030400.11 ENSMUST00000030400.12 ENSMUST00000030400.13 ENSMUST00000030400.2 ENSMUST00000030400.3 ENSMUST00000030400.4 ENSMUST00000030400.5 ENSMUST00000030400.6 ENSMUST00000030400.7 ENSMUST00000030400.8 ENSMUST00000030400.9 MYCBP_MOUSE NM_019660 O88308 Q8R048 Q9EQS3 uc008uql.1 uc008uql.2 uc008uql.3 May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC (By similarity). Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP. Interacts with CFAP91. Cytoplasm Nucleus Note=Translocates into the nucleus in the S phase of the cell cycle. MYCBP expression is synergistically activated by SP1 and GATA-1. Belongs to the AMY1 family. transcription coactivator activity nucleus cytoplasm regulation of transcription, DNA-templated positive regulation of nucleic acid-templated transcription uc008uql.1 uc008uql.2 uc008uql.3 
ENSMUST00000030401.14 Ndufs5 ENSMUST00000030401.14 NADH:ubiquinone oxidoreductase core subunit S5 (from RefSeq NM_001030274.1) ENSMUST00000030401.1 ENSMUST00000030401.10 ENSMUST00000030401.11 ENSMUST00000030401.12 ENSMUST00000030401.13 ENSMUST00000030401.2 ENSMUST00000030401.3 ENSMUST00000030401.4 ENSMUST00000030401.5 ENSMUST00000030401.6 ENSMUST00000030401.7 ENSMUST00000030401.8 ENSMUST00000030401.9 NDUS5_MOUSE NM_001030274 Q3U734 Q99LY9 uc008upu.1 uc008upu.2 uc008upu.3 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme. Mitochondrion inner membrane ; Peripheral membrane protein Mitochondrion intermembrane space Contains two C-X9-C motifs that are predicted to form a helix- coil-helix structure, permitting the formation of intramolecular disulfide bonds. Belongs to the complex I NDUFS5 subunit family. molecular_function mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial intermembrane space membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc008upu.1 uc008upu.2 uc008upu.3 
ENSMUST00000030404.5 Ppie ENSMUST00000030404.5 peptidylprolyl isomerase E (cyclophilin E) (from RefSeq NM_019489.6) Cyp33 ENSMUST00000030404.1 ENSMUST00000030404.2 ENSMUST00000030404.3 ENSMUST00000030404.4 NM_019489 PPIE_MOUSE Q9D8C0 Q9QZH3 uc008uow.1 uc008uow.2 uc008uow.3 Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'- UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19. Interacts (via RNA-binding domain) with KMT2A (via the third PHD-type zinc-finger). Nucleus The RRM domain mediates both interaction with RNA and with KMT2A (via the third PHD-type zinc-finger), but has much higher affinity for the KMT2A PHD-type zinc-finger. Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. mRNA splicing, via spliceosome protein peptidyl-prolyl isomerization nucleic acid binding RNA binding mRNA binding peptidyl-prolyl cis-trans isomerase activity nucleus spliceosomal complex cytosol regulation of transcription, DNA-templated mRNA processing protein folding poly(A) binding RNA splicing cyclosporin A binding nuclear speck isomerase activity protein refolding positive regulation of viral genome replication unfolded protein binding U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome uc008uow.1 uc008uow.2 uc008uow.3 
ENSMUST00000030408.12 Mfsd2a ENSMUST00000030408.12 MFSD2 lysolipid transporter A, lysophospholipid (from RefSeq NM_029662.2) ENSMUST00000030408.1 ENSMUST00000030408.10 ENSMUST00000030408.11 ENSMUST00000030408.2 ENSMUST00000030408.3 ENSMUST00000030408.4 ENSMUST00000030408.5 ENSMUST00000030408.6 ENSMUST00000030408.7 ENSMUST00000030408.8 ENSMUST00000030408.9 Mfsd2 Mfsd2a NLS1_MOUSE NM_029662 Nls1 Q80ZW8 Q9DA75 uc008uoo.1 uc008uoo.2 uc008uoo.3 uc008uoo.4 Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed:18694395, PubMed:23209793, PubMed:24828044, PubMed:24828040, PubMed:34349262). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (PubMed:24828044, PubMed:24828040, PubMed:34349262). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed:24828044, PubMed:24828040, PubMed:34349262). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (PubMed:24828044, PubMed:34349262). Does not transport docosahexaenoic acid in unesterified fatty acid (PubMed:24828044). Not required for central nervous system vascular morphogenesis (PubMed:24828040). Reaction=a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = a 1- acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out); Xref=Rhea:RHEA:44376, ChEBI:CHEBI:29101, ChEBI:CHEBI:58168; Evidence=; Reaction=1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3- phosphocholine(in) + Na(+)(in) = 1-(4Z,7Z,10Z,13Z,16Z,19Z- docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out); Xref=Rhea:RHEA:43860, ChEBI:CHEBI:29101, ChEBI:CHEBI:73873; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out); Xref=Rhea:RHEA:43856, ChEBI:CHEBI:28610, ChEBI:CHEBI:29101; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out); Xref=Rhea:RHEA:43864, ChEBI:CHEBI:29101, ChEBI:CHEBI:72998; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out); Xref=Rhea:RHEA:43868, ChEBI:CHEBI:29101, ChEBI:CHEBI:64381; Evidence=; Cell membrane ulti-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Widely expressed. Exhibits an oscillatory pattern of expression in brown adipose tissue and liver consistent with a circadian rhythm. Enriched in brain micro-vessels, where it is specifically present in endothelium constituting the blood-brain barrier (at protein level) (PubMed:24828044, PubMed:24828040). By fasting in liver and brown adipose tissue as well as by cold exposure in brown adipose tissue. Expression following fasting is dependent on glucagon signaling and Ppara. N-glycosylated. Mice are born at Mendelian ratios, but show increased postnatal mortality early in life (PubMed:24828044). Mice are smaller, leaner and have decreased serum, liver and brown adipose triglycerides (PubMed:23209793). After weaning, mice display motor dysfunction with front-paw clasping during tail suspension. Brain size and weight are also significantly lower. Behavioral tests indicate that mice have deficits in learning, and short- and long-term memory, as well as severe anxiety, a phenotype related to omega-3 fatty-acid deficiency. Lipidomic analysis of knockout mice shows strongly reduced levels of docosahexaenoic acid (DHA) in brain accompanied by neuronal cell loss in hippocampus and cerebellum (PubMed:24828044). Mice also show a leaky blood-brain barrier from embryonic stages through to adulthood, while the normal patterning of vascular networks is maintained. Electron microscopy analysis shows an increase in central nervous system-endothelial-cell vesicular transcytosis not associated with tight-junction defects (PubMed:24828040). Mice have an increase in plasma levels of LPC (PubMed:26005868). Belongs to the major facilitator superfamily. endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane lipid transport carbohydrate transport fatty acid transporter activity symporter activity fatty acid transport membrane integral component of membrane hippocampus development transcytosis lysophospholipid transport lysophospholipid transporter activity transmembrane transport establishment of blood-brain barrier organic substance transport lipid transport across blood brain barrier uc008uoo.1 uc008uoo.2 uc008uoo.3 uc008uoo.4 
ENSMUST00000030412.11 Ppt1 ENSMUST00000030412.11 palmitoyl-protein thioesterase 1 (from RefSeq NM_008917.3) ENSMUST00000030412.1 ENSMUST00000030412.10 ENSMUST00000030412.2 ENSMUST00000030412.3 ENSMUST00000030412.4 ENSMUST00000030412.5 ENSMUST00000030412.6 ENSMUST00000030412.7 ENSMUST00000030412.8 ENSMUST00000030412.9 NM_008917 Ppt1 Q3U6J9 Q3U6J9_MOUSE uc008uoh.1 uc008uoh.2 uc008uoh.3 uc008uoh.4 Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; EC=3.1.2.22; Evidence=; Belongs to the palmitoyl-protein thioesterase family. protein depalmitoylation extracellular region nucleus lysosome Golgi apparatus receptor-mediated endocytosis pinocytosis lysosomal lumen acidification nervous system development brain development synaptic vesicle palmitoyl-(protein) hydrolase activity protein transport lipid catabolic process palmitoyl-CoA hydrolase activity negative regulation of cell growth axon membrane raft organization neuron projection neuronal cell body negative regulation of apoptotic process negative regulation of neuron apoptotic process membrane raft synapse positive regulation of receptor-mediated endocytosis positive regulation of pinocytosis cofactor transport cofactor metabolic process palmitoyl hydrolase activity uc008uoh.1 uc008uoh.2 uc008uoh.3 uc008uoh.4 
ENSMUST00000030420.9 Epha8 ENSMUST00000030420.9 Eph receptor A8, transcript variant 4 (from RefSeq NR_185216.1) A3KG07 ENSMUST00000030420.1 ENSMUST00000030420.2 ENSMUST00000030420.3 ENSMUST00000030420.4 ENSMUST00000030420.5 ENSMUST00000030420.6 ENSMUST00000030420.7 ENSMUST00000030420.8 EPHA8_MOUSE Eek NR_185216 O09127 uc008vis.1 uc008vis.2 Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). May also form heterodimers with other ephrin receptors. Interacts with FYN; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PIK3CG; regulates integrin-mediated cell adhesion to substrate. Interacts with TIAM1; regulates clathrin-mediated endocytosis of EPHA8. Interacts with ANKS1A and ANKS1B; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination. Cell membrane ; Single-pass type I membrane protein Cell projection Early endosome membrane Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes (PubMed:20496116). Specifically expressed in the central nervous system. First detected at 10.5 dpc with high levels near the midline region of the tectum and to a lower extent in discrete regions of hindbrain, the dorsal horn, of the spinal cord and in the naso-lacrimal groove. The expression decreases at 12.5 dpc and is barely detectable at 17.5 dpc. Not detected at postnatal stages. Phosphorylated. Phosphorylation is stimulated upon binding of its ligands including EFNA2, EFNA3 and EFNA5. Autophosphorylation on Tyr- 615 is critical for association with FYN. Autophosphorylation on Tyr- 838 modulates tyrosine kinase activity. Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity GPI-linked ephrin receptor activity transmembrane-ephrin receptor activity protein binding ATP binding endosome plasma membrane integral component of plasma membrane protein phosphorylation substrate-dependent cell migration cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development axon guidance membrane integral component of membrane kinase activity phosphorylation neuron remodeling transferase activity peptidyl-tyrosine phosphorylation regulation of cell adhesion neuron projection development early endosome membrane regulation of cell adhesion mediated by integrin cell projection neuron projection receptor complex positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity protein autophosphorylation ephrin receptor signaling pathway cellular response to follicle-stimulating hormone stimulus uc008vis.1 uc008vis.2 
ENSMUST00000030427.6 Eloa ENSMUST00000030427.6 elongin A (from RefSeq NM_013736.4) ELOA1_MOUSE ENSMUST00000030427.1 ENSMUST00000030427.2 ENSMUST00000030427.3 ENSMUST00000030427.4 ENSMUST00000030427.5 Eloa NM_013736 Q3UI38 Q80VB2 Q8CB77 Q9R0Q5 Tceb3 uc008vhp.1 uc008vhp.2 uc008vhp.3 SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A. Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit (By similarity). Part of a multisubunit ubiquitin ligase complex consisting of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5 (By similarity). Interacts with ERCC6; the interaction is induced by DNA damaging agents or inhibitors of RNA polymerase II elongation (By similarity). Interacts (via BC-box) with CUL5 (By similarity). Nucleus Note=Localizes to sites of DNA damage. The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x(3)-C-x(3)-[AILV]. nucleus regulation of transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter transcription elongation factor complex elongin complex uc008vhp.1 uc008vhp.2 uc008vhp.3 
ENSMUST00000030432.8 Hmgcl ENSMUST00000030432.8 3-hydroxy-3-methylglutaryl-Coenzyme A lyase, transcript variant 13 (from RefSeq NR_185231.1) ENSMUST00000030432.1 ENSMUST00000030432.2 ENSMUST00000030432.3 ENSMUST00000030432.4 ENSMUST00000030432.5 ENSMUST00000030432.6 ENSMUST00000030432.7 HMGCL_MOUSE NR_185231 P38060 Q8QZS6 uc012dnc.1 uc012dnc.2 uc012dnc.3 Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. Reaction=(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA; Xref=Rhea:RHEA:24404, ChEBI:CHEBI:13705, ChEBI:CHEBI:43074, ChEBI:CHEBI:57288; EC=4.1.3.4; Evidence=; Metabolic intermediate metabolism; (S)-3-hydroxy-3- methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3- methylglutaryl-CoA: step 1/1. Homodimer; disulfide-linked. Can also form homotetramers. Mitochondrion matrix Peroxisome Note=Unprocessed form is peroxisomal. Belongs to the HMG-CoA lyase family. fatty-acyl-CoA binding magnesium ion binding liver development catalytic activity hydroxymethylglutaryl-CoA lyase activity mitochondrion mitochondrial inner membrane mitochondrial matrix peroxisome leucine catabolic process lipid metabolic process acyl-CoA metabolic process mitochondrion organization response to nutrient lyase activity manganese ion binding carboxylic acid binding response to starvation protein homodimerization activity metal ion binding ketone body biosynthetic process protein tetramerization response to fatty acid uc012dnc.1 uc012dnc.2 uc012dnc.3 
ENSMUST00000030434.5 Fuca1 ENSMUST00000030434.5 fucosidase, alpha-L- 1, tissue (from RefSeq NM_024243.4) B1AV51 ENSMUST00000030434.1 ENSMUST00000030434.2 ENSMUST00000030434.3 ENSMUST00000030434.4 FUCO_MOUSE Fuca NM_024243 Q3UAH8 Q8BN13 Q99LJ1 Q9DD22 uc008vhi.1 uc008vhi.2 uc008vhi.3 uc008vhi.4 Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Reaction=an alpha-L-fucoside + H2O = an alcohol + L-fucose; Xref=Rhea:RHEA:12288, ChEBI:CHEBI:2181, ChEBI:CHEBI:15377, ChEBI:CHEBI:28349, ChEBI:CHEBI:30879; EC=3.2.1.51; Evidence=; Reaction=a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + L-fucose; Xref=Rhea:RHEA:48224, ChEBI:CHEBI:2181, ChEBI:CHEBI:15377, ChEBI:CHEBI:17006, ChEBI:CHEBI:28691; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48225; Evidence=; Reaction=a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside nLc4Cer(d18:0) + L-fucose; Xref=Rhea:RHEA:49308, ChEBI:CHEBI:2181, ChEBI:CHEBI:15377, ChEBI:CHEBI:91119, ChEBI:CHEBI:91121; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49309; Evidence=; Homotetramer. Lysosome Belongs to the glycosyl hydrolase 29 family. alpha-L-fucosidase activity lysosome carbohydrate metabolic process fucose metabolic process metabolic process fucosidase activity glycoside catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds carbohydrate binding uc008vhi.1 uc008vhi.2 uc008vhi.3 uc008vhi.4 
ENSMUST00000030436.12 Pnrc2 ENSMUST00000030436.12 proline-rich nuclear receptor coactivator 2 (from RefSeq NM_026383.3) B1AV48 B1AV49 ENSMUST00000030436.1 ENSMUST00000030436.10 ENSMUST00000030436.11 ENSMUST00000030436.2 ENSMUST00000030436.3 ENSMUST00000030436.4 ENSMUST00000030436.5 ENSMUST00000030436.6 ENSMUST00000030436.7 ENSMUST00000030436.8 ENSMUST00000030436.9 NM_026383 PNRC2_MOUSE Q9CR73 Q9CXC6 uc008vhf.1 uc008vhf.2 uc008vhf.3 uc008vhf.4 Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (By similarity). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (By similarity). Required for UPF1/RENT1 localization to the P-body (By similarity). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand- dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure (PubMed:17971453). Interacts with UPF1/RENT1; preferentially interacts with hyperphosphorylated form. Interacts with DCP1A. Interacts with many nuclear receptors including ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR. Nucleus Cytoplasm, P-body Strong expression is detected in lung, spleen, ovary, thymus, and colon. The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif. Mice are lean, resistant to high fat diet-induced obesity but without the induction of insulin resistance and have a higher metabolic rate than wild-type mice. Belongs to the PNRC family. PNRC2 subfamily. Sequence=CAM15897.1; Type=Erroneous gene model prediction; Evidence=; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay P-body nucleus nucleoplasm cytoplasm Golgi apparatus uc008vhf.1 uc008vhf.2 uc008vhf.3 uc008vhf.4 
ENSMUST00000030443.12 Ptch2 ENSMUST00000030443.12 patched 2, transcript variant 1 (from RefSeq NM_008958.3) A2AE82 ENSMUST00000030443.1 ENSMUST00000030443.10 ENSMUST00000030443.11 ENSMUST00000030443.2 ENSMUST00000030443.3 ENSMUST00000030443.4 ENSMUST00000030443.5 ENSMUST00000030443.6 ENSMUST00000030443.7 ENSMUST00000030443.8 ENSMUST00000030443.9 NM_008958 O35595 PTC2_MOUSE Q546T0 uc008uhx.1 uc008uhx.2 uc008uhx.3 uc008uhx.4 This gene encodes a member of the patched family of transmembrane receptor proteins. The encoded protein may be a functional receptor for the morphogen sonic hedgehog (Shh) and is reportedly involved in limb and skin development. Homozygous mutant mice for this gene exhibit hair loss and epidermal hyperplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. Plays a role in the control of cellular growth (By similarity). May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH). Membrane; Multi-pass membrane protein. Expressed in epithelial cells of the developing hair, tooth and whisker. Detected in 8.5 to 17.5 dpc embryos. Belongs to the patched family. regulation of cell growth cell fate determination smoothened binding plasma membrane smoothened signaling pathway hedgehog receptor activity epidermis development epidermal cell fate specification membrane integral component of membrane hair cycle skin development positive regulation of epidermal cell differentiation hedgehog family protein binding uc008uhx.1 uc008uhx.2 uc008uhx.3 uc008uhx.4 
ENSMUST00000030446.15 Urod ENSMUST00000030446.15 uroporphyrinogen decarboxylase, transcript variant 1 (from RefSeq NM_009478.5) DCUP_MOUSE ENSMUST00000030446.1 ENSMUST00000030446.10 ENSMUST00000030446.11 ENSMUST00000030446.12 ENSMUST00000030446.13 ENSMUST00000030446.14 ENSMUST00000030446.2 ENSMUST00000030446.3 ENSMUST00000030446.4 ENSMUST00000030446.5 ENSMUST00000030446.6 ENSMUST00000030446.7 ENSMUST00000030446.8 ENSMUST00000030446.9 NM_009478 P70697 Q91VW4 Urod uc008uhr.1 uc008uhr.2 uc008uhr.3 This gene encodes an enzyme that catalyzes the conversion of uroporphyrinogen-III to coproporphyrinogen-III, an intermediate step in heme biosynthesis. Homozygous knockout mice for this gene exhibit embryonic lethality. [provided by RefSeq, Aug 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK007470.1, AK172426.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme (By similarity). In vitro also decarboxylates pentacarboxylate porphyrinogen I (PubMed:8661721). Reaction=4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III; Xref=Rhea:RHEA:19865, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57308, ChEBI:CHEBI:57309; EC=4.1.1.37; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19866; Evidence=; Reaction=4 H(+) + uroporphyrinogen I = 4 CO2 + coproporphyrinogen I; Xref=Rhea:RHEA:31239, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:62626, ChEBI:CHEBI:62631; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31240; Evidence=; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. Homodimer. Cytoplasm. Belongs to the uroporphyrinogen decarboxylase family. uroporphyrinogen decarboxylase activity nucleoplasm cytoplasm cytosol porphyrin-containing compound biosynthetic process protoporphyrinogen IX biosynthetic process heme biosynthetic process ferrous iron binding lyase activity carboxy-lyase activity heme metabolic process uroporphyrinogen III metabolic process uc008uhr.1 uc008uhr.2 uc008uhr.3 
ENSMUST00000030451.10 Toe1 ENSMUST00000030451.10 target of EGR1, member 1 (nuclear), transcript variant 5 (from RefSeq NR_185030.1) ENSMUST00000030451.1 ENSMUST00000030451.2 ENSMUST00000030451.3 ENSMUST00000030451.4 ENSMUST00000030451.5 ENSMUST00000030451.6 ENSMUST00000030451.7 ENSMUST00000030451.8 ENSMUST00000030451.9 NR_185030 Q3UFD8 Q8R5A4 Q9D2E2 Q9D412 TOE1_MOUSE uc008uhk.1 uc008uhk.2 uc008uhk.3 Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing. Interacts with U1, U2, U4, U5 and U6 snRNAs. Nucleus, nucleolus Nucleus speckle Note=Localizes to nuclear speckles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D2E2-1; Sequence=Displayed; Name=2; IsoId=Q9D2E2-2; Sequence=VSP_022242, VSP_022243; Belongs to the CAF1 family. 3'-5'-exoribonuclease activity nucleic acid binding poly(A)-specific ribonuclease activity nucleus nucleoplasm nucleolus cytoplasm Cajal body nuclear body nuclear speck snRNA binding snRNA 3'-end processing metal ion binding RNA phosphodiester bond hydrolysis, exonucleolytic uc008uhk.1 uc008uhk.2 uc008uhk.3 
ENSMUST00000030453.5 Mmachc ENSMUST00000030453.5 methylmalonic aciduria cblC type, with homocystinuria (from RefSeq NM_025962.3) ENSMUST00000030453.1 ENSMUST00000030453.2 ENSMUST00000030453.3 ENSMUST00000030453.4 MMAC_MOUSE Mmachc NM_025962 Q9CZD0 Q9D8S7 uc008uhe.1 uc008uhe.2 uc008uhe.3 Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate. Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle. Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether. The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors. Cysteine and homocysteine cannot substitute for glutathione in this reaction. Reaction=2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) = 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH; Xref=Rhea:RHEA:16113, Rhea:RHEA- COMP:14717, Rhea:RHEA-COMP:14718, ChEBI:CHEBI:15378, ChEBI:CHEBI:16304, ChEBI:CHEBI:17439, ChEBI:CHEBI:18407, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:83228; EC=1.16.1.6; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:16115; Evidence=; Reaction=an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione = an S-substituted glutathione + cob(I)alamin- [alkylcobalamin reductase] + H(+); Xref=Rhea:RHEA:40719, Rhea:RHEA- COMP:14730, Rhea:RHEA-COMP:14731, ChEBI:CHEBI:15378, ChEBI:CHEBI:57925, ChEBI:CHEBI:60488, ChEBI:CHEBI:83228, ChEBI:CHEBI:90779, ChEBI:CHEBI:140785; EC=2.5.1.151; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40720; Evidence=; Reaction=apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin = cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione; Xref=Rhea:RHEA:63132, Rhea:RHEA-COMP:14730, Rhea:RHEA-COMP:14731, ChEBI:CHEBI:15378, ChEBI:CHEBI:28115, ChEBI:CHEBI:57925, ChEBI:CHEBI:60488, ChEBI:CHEBI:83228, ChEBI:CHEBI:141467; EC=2.5.1.151; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63133; Evidence=; Reaction=adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione = cob(I)alamin-[alkylcobalamin reductase] + H(+) + S- adenosylglutathione; Xref=Rhea:RHEA:63136, Rhea:RHEA-COMP:14730, Rhea:RHEA-COMP:14731, ChEBI:CHEBI:15378, ChEBI:CHEBI:18408, ChEBI:CHEBI:57925, ChEBI:CHEBI:60488, ChEBI:CHEBI:83228, ChEBI:CHEBI:146184; EC=2.5.1.151; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63137; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Note=Can utilize both FAD and FMN. ; Monomer in the absence of bound substrate. Homodimer; dimerization is triggered by binding to FMN or adenosylcobalamin. Interacts with LMBRD1 and ABCD4; the interaction ensures the transport of cobalamin from the lysosome to the cytoplasm. Forms a multiprotein complex with MMADHC, MTR and MTRR; the interaction with MTR could modulate MMACHC-dependent processing of cobalamin. Heterodimer with MMADHC; the interaction might play a role in the regulation of the balance between AdoCbl and MeCbl synthesis. Cytoplasm, cytosol Detected in liver and kidney (at protein level) (PubMed:21697092). Detected in embryos (PubMed:24889031). Complete embryonic lethality. All die before 3.5 dpc. Belongs to the MMACHC family. Sequence=AAH54756.1; Type=Erroneous initiation; Evidence=; Sequence=BAB25214.1; Type=Frameshift; Evidence=; Sequence=BAC39135.1; Type=Erroneous initiation; Evidence=; cytoplasm mitochondrion glutathione metabolic process cobalamin metabolic process cobalamin biosynthetic process oxidoreductase activity cobalamin binding demethylase activity cyanocobalamin reductase (cyanide-eliminating) activity protein homodimerization activity glutathione binding oxidation-reduction process demethylation FAD binding uc008uhe.1 uc008uhe.2 uc008uhe.3 
ENSMUST00000030455.15 Akr1a1 ENSMUST00000030455.15 aldo-keto reductase family 1, member A1 (from RefSeq NM_021473.3) AK1A1_MOUSE Akr1a4 ENSMUST00000030455.1 ENSMUST00000030455.10 ENSMUST00000030455.11 ENSMUST00000030455.12 ENSMUST00000030455.13 ENSMUST00000030455.14 ENSMUST00000030455.2 ENSMUST00000030455.3 ENSMUST00000030455.4 ENSMUST00000030455.5 ENSMUST00000030455.6 ENSMUST00000030455.7 ENSMUST00000030455.8 ENSMUST00000030455.9 NM_021473 Q9CQI5 Q9CQT8 Q9CT53 Q9D012 Q9D016 Q9D0I7 Q9D0P3 Q9JII6 uc008uha.1 uc008uha.2 uc008uha.3 uc008uha.4 Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity) (PubMed:22820017, PubMed:15769935, PubMed:20410296). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (PubMed:20410296, PubMed:15769935, PubMed:22820017). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic (By similarity). Involved in the detoxification of lipid- derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Displays no reductase activity towards retinoids (By similarity). Reaction=a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH; Xref=Rhea:RHEA:15937, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:17478, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.2; Evidence=; Reaction=L-gulonate + NADP(+) = aldehydo-D-glucuronate + H(+) + NADPH; Xref=Rhea:RHEA:14909, ChEBI:CHEBI:13115, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142686; EC=1.1.1.19; Evidence= Reaction=L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH; Xref=Rhea:RHEA:18925, ChEBI:CHEBI:15378, ChEBI:CHEBI:17587, ChEBI:CHEBI:18268, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.20; Evidence=; Reaction=allyl alcohol + NADP(+) = acrolein + H(+) + NADPH; Xref=Rhea:RHEA:12168, ChEBI:CHEBI:15368, ChEBI:CHEBI:15378, ChEBI:CHEBI:16605, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.54; Evidence=; Reaction=glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH; Xref=Rhea:RHEA:23592, ChEBI:CHEBI:15378, ChEBI:CHEBI:17378, ChEBI:CHEBI:17754, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.372; Evidence=; Reaction=glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH; Xref=Rhea:RHEA:38111, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:27975, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.372; Evidence=; Reaction=hydroxyacetone + NADP(+) = H(+) + methylglyoxal + NADPH; Xref=Rhea:RHEA:27986, ChEBI:CHEBI:15378, ChEBI:CHEBI:17158, ChEBI:CHEBI:27957, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Reaction=3-deoxyfructose + NADP(+) = 3-deoxyglucosone + H(+) + NADPH; Xref=Rhea:RHEA:58668, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60777, ChEBI:CHEBI:142685; Evidence=; Reaction=(R)-mevalonate + NADP(+) = (R)-mevaldate + H(+) + NADPH; Xref=Rhea:RHEA:20193, ChEBI:CHEBI:15378, ChEBI:CHEBI:36464, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:195523; Evidence=; Reaction=NADP(+) + pyridine 3-methanol = H(+) + NADPH + pyridine-3- carbaldehyde; Xref=Rhea:RHEA:58776, ChEBI:CHEBI:15378, ChEBI:CHEBI:28345, ChEBI:CHEBI:45213, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Kinetic parameters: KM=5 mM for D-glucuronate ; Monomer. Cytoplasm, cytosol Apical cell membrane Widely expressed. Detected at high levels in several tissues including neural ectoderm, gut endoderm, somites, branchial arches, otic vesicles, limb buds and tail bud. Fear memory increases expression 7-fold. Deficient mice develop and grow normally but suffer severe osteopenia and spontaneous fractures with stresses that increase ascorbic acid requirements, such as pregnancy or castration (PubMed:20410296). Deficient mice exhibit reduced asorbic acid and D,L- glyceraldehyde levels. The activities of glucuronate reductase and glucuronolactone reductase, which are involved in ascorbic acid biosynthesis, are suppressed in AKR1A knockout mice (PubMed:22820017, PubMed:20410296). Belongs to the aldo/keto reductase family. alditol:NADP+ 1-oxidoreductase activity cytoplasm cytosol plasma membrane alcohol dehydrogenase (NADP+) activity membrane apical plasma membrane oxidoreductase activity mevaldate reductase (NADPH) activity L-ascorbic acid biosynthetic process D-glucuronate catabolic process daunorubicin metabolic process doxorubicin metabolic process synapse aldehyde catabolic process allyl-alcohol dehydrogenase activity L-glucuronate reductase activity glucuronolactone reductase activity oxidation-reduction process retinol dehydrogenase activity uc008uha.1 uc008uha.2 uc008uha.3 uc008uha.4 
ENSMUST00000030457.12 Nasp ENSMUST00000030457.12 nuclear autoantigenic sperm protein (histone-binding), transcript variant 1 (from RefSeq NM_001081475.1) B1AU76 B1AU76_MOUSE ENSMUST00000030457.1 ENSMUST00000030457.10 ENSMUST00000030457.11 ENSMUST00000030457.2 ENSMUST00000030457.3 ENSMUST00000030457.4 ENSMUST00000030457.5 ENSMUST00000030457.6 ENSMUST00000030457.7 ENSMUST00000030457.8 ENSMUST00000030457.9 NM_001081475 Nasp uc008ugx.1 uc008ugx.2 Nucleus Belongs to the NASP family. uc008ugx.1 uc008ugx.2 
ENSMUST00000030460.15 Gpbp1l1 ENSMUST00000030460.15 GC-rich promoter binding protein 1-like 1, transcript variant 1 (from RefSeq NM_029868.4) ENSMUST00000030460.1 ENSMUST00000030460.10 ENSMUST00000030460.11 ENSMUST00000030460.12 ENSMUST00000030460.13 ENSMUST00000030460.14 ENSMUST00000030460.2 ENSMUST00000030460.3 ENSMUST00000030460.4 ENSMUST00000030460.5 ENSMUST00000030460.6 ENSMUST00000030460.7 ENSMUST00000030460.8 ENSMUST00000030460.9 GPBL1_MOUSE NM_029868 Q6NZP2 Q8BHW7 Q8BI03 Q8K2H8 Q9CTV6 uc008ugr.1 uc008ugr.2 uc008ugr.3 Possible transcription factor. Nucleus Belongs to the vasculin family. Sequence=BAC36644.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated uc008ugr.1 uc008ugr.2 uc008ugr.3 
ENSMUST00000030461.5 Ipp ENSMUST00000030461.5 May play a role in organizing the actin cytoskeleton. (from UniProt P28575) AK131718 ENSMUST00000030461.1 ENSMUST00000030461.2 ENSMUST00000030461.3 ENSMUST00000030461.4 IPP_MOUSE Mipp P28575 Q3V2M0 uc290oyq.1 uc290oyq.2 May play a role in organizing the actin cytoskeleton. Cytoplasm, cytoskeleton. Expression seems confined to tissues derived from trophectoderm and primitive endoderm. Sequence=AAK00278.1; Type=Frameshift; Evidence=; Sequence=CAA41413.1; Type=Frameshift; Evidence=; Sequence=CAA41414.1; Type=Frameshift; Evidence=; actin binding cytoplasm cytoskeleton uc290oyq.1 uc290oyq.2 
ENSMUST00000030464.14 Pik3r3 ENSMUST00000030464.14 phosphoinositide-3-kinase regulatory subunit 3, transcript variant 1 (from RefSeq NM_181585.7) ENSMUST00000030464.1 ENSMUST00000030464.10 ENSMUST00000030464.11 ENSMUST00000030464.12 ENSMUST00000030464.13 ENSMUST00000030464.2 ENSMUST00000030464.3 ENSMUST00000030464.4 ENSMUST00000030464.5 ENSMUST00000030464.6 ENSMUST00000030464.7 ENSMUST00000030464.8 ENSMUST00000030464.9 NM_181585 P55G_MOUSE Q64143 uc008ugm.1 uc008ugm.2 uc008ugm.3 Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL (By similarity). Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Barely detectable in liver and spleen. Belongs to the PI3K p85 subunit family. phosphotyrosine binding positive regulation of protein phosphorylation cell migration involved in sprouting angiogenesis protein binding phosphatidylinositol 3-kinase complex insulin receptor signaling pathway positive regulation of gene expression protein kinase B signaling regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity uc008ugm.1 uc008ugm.2 uc008ugm.3 
ENSMUST00000030465.10 Tspan1 ENSMUST00000030465.10 tetraspanin 1 (from RefSeq NM_133681.4) A6PW93 ENSMUST00000030465.1 ENSMUST00000030465.2 ENSMUST00000030465.3 ENSMUST00000030465.4 ENSMUST00000030465.5 ENSMUST00000030465.6 ENSMUST00000030465.7 ENSMUST00000030465.8 ENSMUST00000030465.9 NM_133681 Q99J59 TSN1_MOUSE uc008ugk.1 uc008ugk.2 uc008ugk.3 Lysosome membrane ; Multi-pass membrane protein Belongs to the tetraspanin (TM4SF) family. Sequence=CAO78026.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAO78128.1; Type=Erroneous gene model prediction; Evidence=; nucleoplasm cytoplasm lysosome lysosomal membrane plasma membrane integral component of plasma membrane cell proliferation membrane integral component of membrane cell migration cell junction vesicle intracellular membrane-bounded organelle positive regulation of endocytosis perinuclear region of cytoplasm protein stabilization uc008ugk.1 uc008ugk.2 uc008ugk.3 
ENSMUST00000030469.5 Lurap1 ENSMUST00000030469.5 leucine rich adaptor protein 1 (from RefSeq NM_026547.1) ENSMUST00000030469.1 ENSMUST00000030469.2 ENSMUST00000030469.3 ENSMUST00000030469.4 LURA1_MOUSE Lrap35a Lrp35a NM_026547 Q9D6I9 uc008ugg.1 uc008ugg.2 uc008ugg.3 uc008ugg.4 Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). Forms a tripartite complex with CDC42BPA/CDC42BPB and MYO18A acting as an adapter connecting both. Its binding to CDC42BPA/CDC42BPB results in their activation by abolition of their negative autoregulation. Interacts with CDC42BPA and CDC42BPB. Cytoplasm Phosphorylated. positive regulation of cytokine production molecular_function cytoplasm cell migration actomyosin structure organization actomyosin positive regulation of I-kappaB kinase/NF-kappaB signaling intracellular membrane-bounded organelle uc008ugg.1 uc008ugg.2 uc008ugg.3 uc008ugg.4 
ENSMUST00000030471.9 Lrrc41 ENSMUST00000030471.9 leucine rich repeat containing 41 (from RefSeq NM_153521.2) A2A911 ENSMUST00000030471.1 ENSMUST00000030471.2 ENSMUST00000030471.3 ENSMUST00000030471.4 ENSMUST00000030471.5 ENSMUST00000030471.6 ENSMUST00000030471.7 ENSMUST00000030471.8 LRC41_MOUSE Muf1 NM_153521 Q3U3S2 Q6IQY7 Q8K1C9 Q91VX4 uc008ufy.1 uc008ufy.2 uc008ufy.3 uc008ufy.4 Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Part of an E3 ubiquitin-protein ligase complex with Elongin BC (ELOB and ELOC), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, ELOB and ELOC (By similarity). The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]. It is uncertain whether Met-1 or Met-23 is the initiator. Sequence=AAH22976.2; Type=Erroneous initiation; Evidence=; protein binding nucleus cytoplasm biological_process protein ubiquitination protein homodimerization activity uc008ufy.1 uc008ufy.2 uc008ufy.3 uc008ufy.4 
ENSMUST00000030475.3 Nsun4 ENSMUST00000030475.3 NOL1/NOP2/Sun domain family, member 4, transcript variant 1 (from RefSeq NM_028142.5) ENSMUST00000030475.1 ENSMUST00000030475.2 NM_028142 NSUN4_MOUSE Q9CZ57 Q9D7F0 Shtap uc008ufu.1 uc008ufu.2 uc008ufu.3 uc008ufu.4 Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA at position 911; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4. Reaction=a cytidine in rRNA + S-adenosyl-L-methionine = a 5- methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61484, Rhea:RHEA-COMP:15836, Rhea:RHEA-COMP:15837, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence=; Reaction=a cytidine in tRNA + S-adenosyl-L-methionine = a 5- methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61468, Rhea:RHEA-COMP:13670, Rhea:RHEA-COMP:15827, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence=; Heterodimer with MTERFD2/MTERF4; this interaction seems to be required for NSUN4 recruitment to the mitochondrial large ribosomal subunit. Mitochondrion Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9CZ57-1; Sequence=Displayed; Name=2; IsoId=Q9CZ57-2; Sequence=VSP_025974, VSP_025975; Name=3; IsoId=C4P6S0-1; Sequence=External; Name=4; IsoId=C4P6S0-2; Sequence=External; Embryonic lethal. Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. tRNA binding RNA binding nucleus cytoplasm mitochondrion mitochondrial large ribosomal subunit rRNA processing methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity transferase activity rRNA binding tRNA methylation rRNA methylation methylation ribosome biogenesis mature ribosome assembly positive regulation of mitochondrial translation small ribosomal subunit rRNA binding uc008ufu.1 uc008ufu.2 uc008ufu.3 uc008ufu.4 
ENSMUST00000030477.4 Mob3c ENSMUST00000030477.4 MOB kinase activator 3C (from RefSeq NM_175308.5) ENSMUST00000030477.1 ENSMUST00000030477.2 ENSMUST00000030477.3 MOB3C_MOUSE Mobkl2c NM_175308 Q3UFI6 Q8BJG4 uc008ufk.1 uc008ufk.2 uc008ufk.3 May regulate the activity of kinases. Belongs to the MOB1/phocein family. molecular_function cellular_component biological_process metal ion binding uc008ufk.1 uc008ufk.2 uc008ufk.3 
ENSMUST00000030486.15 Cyp4a31 ENSMUST00000030486.15 cytochrome P450, family 4, subfamily a, polypeptide 31, transcript variant 1 (from RefSeq NM_201640.3) Cyp4a31 ENSMUST00000030486.1 ENSMUST00000030486.10 ENSMUST00000030486.11 ENSMUST00000030486.12 ENSMUST00000030486.13 ENSMUST00000030486.14 ENSMUST00000030486.2 ENSMUST00000030486.3 ENSMUST00000030486.4 ENSMUST00000030486.5 ENSMUST00000030486.6 ENSMUST00000030486.7 ENSMUST00000030486.8 ENSMUST00000030486.9 F8WGU9 F8WGU9_MOUSE NM_201640 uc029uyu.1 uc029uyu.2 Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm arachidonic acid monooxygenase activity arachidonic acid epoxygenase activity apical plasma membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen alkane 1-monooxygenase activity heme binding leukotriene B4 catabolic process intracellular membrane-bounded organelle metal ion binding leukotriene-B4 20-monooxygenase activity oxidation-reduction process uc029uyu.1 uc029uyu.2 
ENSMUST00000030487.3 Cyp4a14 ENSMUST00000030487.3 cytochrome P450, family 4, subfamily a, polypeptide 14 (from RefSeq NM_007822.2) A2A975 CP4AE_MOUSE Cyp4a14 ENSMUST00000030487.1 ENSMUST00000030487.2 NM_007822 O35728 Q3UER2 Q5EBH0 uc008uev.1 uc008uev.2 uc008uev.3 uc008uev.4 A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:17112342). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:17112342). Catalyzes the hydroxylation of saturated carbon hydrogen bonds of fatty acids (PubMed:17112342). May act as a major omega- and ommega-1 hydroxylase for dodecanoic (lauric) acid in kidney (PubMed:17112342). Catalyzes with low efficiency the epoxidation of 11,12-double bond of arachidonic acid (PubMed:17112342). Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38947, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:36204, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38948; Evidence=; Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39751, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76628; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39752; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51480, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76625; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51481; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Kinetic parameters: KM=8 uM for dodecanoic acid ; Vmax=40 nmol/min/nmol enzyme toward dodecanoic acid ; Lipid metabolism; fatty acid metabolism. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Gender- and strain-specific expression in kidney (at protein level). Predominantly expressed in females, the expression among strains decreasing in the following order: FVB/N > NMRI > Balb/c > 129 Sv/J > C57BL/6 (PubMed:17112342). Expressed at very low level in liver, kidney and spleen of both male and female C57BL/6 X CBA hybrid mice (PubMed:9271096). By peroxisome proliferator methylclofenapate; 1000-fold in liver, 10-fold in kidney. Belongs to the cytochrome P450 family. Sequence=BC089609; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; monooxygenase activity fatty acid binding iron ion binding endoplasmic reticulum endoplasmic reticulum membrane arachidonic acid monooxygenase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen alkane 1-monooxygenase activity heme binding organelle membrane intracellular membrane-bounded organelle metal ion binding arachidonic acid binding oxidation-reduction process uc008uev.1 uc008uev.2 uc008uev.3 uc008uev.4 
ENSMUST00000030489.9 Tal1 ENSMUST00000030489.9 T cell acute lymphocytic leukemia 1, transcript variant 1 (from RefSeq NM_011527.4) ENSMUST00000030489.1 ENSMUST00000030489.2 ENSMUST00000030489.3 ENSMUST00000030489.4 ENSMUST00000030489.5 ENSMUST00000030489.6 ENSMUST00000030489.7 ENSMUST00000030489.8 NM_011527 Q3TZH7 Q3TZH7_MOUSE Tal1 uc008uem.1 uc008uem.2 uc008uem.3 histone deacetylase complex nuclear chromatin RNA polymerase II transcription factor binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor complex enzyme binding erythrocyte differentiation megakaryocyte differentiation basophil differentiation positive regulation of protein complex assembly Lsd1/2 complex histone deacetylase binding positive regulation of erythrocyte differentiation positive regulation of chromatin assembly or disassembly positive regulation of transcription, DNA-templated positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter protein dimerization activity positive regulation of cell division E-box binding uc008uem.1 uc008uem.2 uc008uem.3 
ENSMUST00000030490.13 Stil ENSMUST00000030490.13 Scl/Tal1 interrupting locus, transcript variant 1 (from RefSeq NM_009185.3) ENSMUST00000030490.1 ENSMUST00000030490.10 ENSMUST00000030490.11 ENSMUST00000030490.12 ENSMUST00000030490.2 ENSMUST00000030490.3 ENSMUST00000030490.4 ENSMUST00000030490.5 ENSMUST00000030490.6 ENSMUST00000030490.7 ENSMUST00000030490.8 ENSMUST00000030490.9 NM_009185 uc008ueh.1 uc008ueh.2 uc008ueh.3 uc008ueh.4 uc008ueh.5 This gene encodes a centrosomal protein ubiquitously expressed in proliferating cells and during early embryonic development. Mice lacking the encoded protein die in utero with marked growth retardation, defects in the developing neural fold and randomization of left-right asymmetry. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]. uc008ueh.1 uc008ueh.2 uc008ueh.3 uc008ueh.4 uc008ueh.5 
ENSMUST00000030491.9 Cmpk1 ENSMUST00000030491.9 cytidine/uridine monophosphate kinase 1 (from RefSeq NM_025647.3) A0A0R4J093 A0A0R4J093_MOUSE CMPK CMPK1 Cmpk1 ENSMUST00000030491.1 ENSMUST00000030491.2 ENSMUST00000030491.3 ENSMUST00000030491.4 ENSMUST00000030491.5 ENSMUST00000030491.6 ENSMUST00000030491.7 ENSMUST00000030491.8 NM_025647 uc008ueg.1 uc008ueg.2 uc008ueg.3 uc008ueg.4 Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. Reaction=ATP + CMP = ADP + CDP; Xref=Rhea:RHEA:11600, ChEBI:CHEBI:30616, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.4.14; Evidence= Reaction=ATP + UMP = ADP + UDP; Xref=Rhea:RHEA:24400, ChEBI:CHEBI:30616, ChEBI:CHEBI:57865, ChEBI:CHEBI:58223, ChEBI:CHEBI:456216; EC=2.7.4.14; Evidence= Reaction=ATP + dCMP = ADP + dCDP; Xref=Rhea:RHEA:25094, ChEBI:CHEBI:30616, ChEBI:CHEBI:57566, ChEBI:CHEBI:58593, ChEBI:CHEBI:456216; EC=2.7.4.14; Evidence= Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence= Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per monomer. ; Monomer. Cytoplasm cleus te=Predominantly nuclear. Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. nucleotide binding cytidylate kinase activity nucleoside diphosphate kinase activity ATP binding nucleus nucleolus cytoplasm nucleobase-containing compound metabolic process nucleoside diphosphate phosphorylation 'de novo' pyrimidine nucleobase biosynthetic process pyrimidine nucleotide biosynthetic process uridylate kinase activity nucleoside triphosphate biosynthetic process kinase activity phosphorylation transferase activity nucleobase-containing compound kinase activity nucleoside monophosphate phosphorylation uc008ueg.1 uc008ueg.2 uc008ueg.3 uc008ueg.4 
ENSMUST00000030501.15 Ebna1bp2 ENSMUST00000030501.15 EBNA1 binding protein 2 (from RefSeq NM_026932.4) A2ACZ0 EBP2_MOUSE ENSMUST00000030501.1 ENSMUST00000030501.10 ENSMUST00000030501.11 ENSMUST00000030501.12 ENSMUST00000030501.13 ENSMUST00000030501.14 ENSMUST00000030501.2 ENSMUST00000030501.3 ENSMUST00000030501.4 ENSMUST00000030501.5 ENSMUST00000030501.6 ENSMUST00000030501.7 ENSMUST00000030501.8 ENSMUST00000030501.9 Ebp2 NM_026932 Q3TKB5 Q9D903 uc008ukn.1 uc008ukn.2 uc008ukn.3 Required for the processing of the 27S pre-rRNA. Interacts with WDR46. Nucleus, nucleolus Belongs to the EBP2 family. nucleus nucleolus rRNA processing preribosome, large subunit precursor nuclear periphery ribosome biogenesis ribosomal large subunit biogenesis uc008ukn.1 uc008ukn.2 uc008ukn.3 
ENSMUST00000030508.14 Pax7 ENSMUST00000030508.14 paired box 7 (from RefSeq NM_011039.3) ENSMUST00000030508.1 ENSMUST00000030508.10 ENSMUST00000030508.11 ENSMUST00000030508.12 ENSMUST00000030508.13 ENSMUST00000030508.2 ENSMUST00000030508.3 ENSMUST00000030508.4 ENSMUST00000030508.5 ENSMUST00000030508.6 ENSMUST00000030508.7 ENSMUST00000030508.8 ENSMUST00000030508.9 NM_011039 P47239 PAX7_MOUSE Pax-7 Q9ES16 uc008vms.1 uc008vms.2 uc008vms.3 Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration. Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX (By similarity). Interacts with PAXBP1; the interaction links PAX7 to a WDR5-containing histone methyltransferase complex (PubMed:22862948). Nucleus Expressed specifically during the development of the nervous and muscular system. Belongs to the paired homeobox family. RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex chromatin remodeling regulation of transcription, DNA-templated multicellular organism development muscle organ development skeletal muscle tissue development animal organ morphogenesis regulation of cell fate commitment regulation of gene expression skeletal muscle satellite cell commitment spinal cord association neuron differentiation dorsal/ventral neural tube patterning positive regulation of histone methylation skeletal muscle tissue regeneration sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter neuron fate commitment embryonic skeletal system development regulation of DNA binding cartilage development muscle tissue morphogenesis positive regulation of myoblast proliferation uc008vms.1 uc008vms.2 uc008vms.3 
ENSMUST00000030510.14 Tas1r2 ENSMUST00000030510.14 taste receptor, type 1, member 2 (from RefSeq NM_031873.1) B1AXX0 ENSMUST00000030510.1 ENSMUST00000030510.10 ENSMUST00000030510.11 ENSMUST00000030510.12 ENSMUST00000030510.13 ENSMUST00000030510.2 ENSMUST00000030510.3 ENSMUST00000030510.4 ENSMUST00000030510.5 ENSMUST00000030510.6 ENSMUST00000030510.7 ENSMUST00000030510.8 ENSMUST00000030510.9 Gpr71 NM_031873 Q923J8 Q925I4 T1r2 TS1R2_MOUSE Tr2 uc008vmr.1 uc008vmr.2 uc008vmr.3 Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. Forms heterodimers with TAS1R3. Cell membrane; Multi-pass membrane protein. Expressed mainly in circumvallate and foliate taste papillae. Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily. detection of chemical stimulus involved in sensory perception of sweet taste G-protein coupled receptor activity protein binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway taste receptor activity membrane integral component of membrane positive regulation of cytokinesis sweet taste receptor activity signaling receptor activity receptor complex response to stimulus sensory perception of taste sensory perception of sweet taste sweet taste receptor complex uc008vmr.1 uc008vmr.2 uc008vmr.3 
ENSMUST00000030526.7 Pla2g2f ENSMUST00000030526.7 phospholipase A2, group IIF, transcript variant 1 (from RefSeq NM_012045.5) ENSMUST00000030526.1 ENSMUST00000030526.2 ENSMUST00000030526.3 ENSMUST00000030526.4 ENSMUST00000030526.5 ENSMUST00000030526.6 NM_012045 PA2GF_MOUSE Q8CE14 Q9QZT4 uc008vlf.1 uc008vlf.2 uc008vlf.3 uc008vlf.4 Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:10531313). Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines (PubMed:11877435, PubMed:10531313). May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (PubMed:10531313). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'- sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero- 3-phospho-(1'-sn-glycerol) + H(+); Xref=Rhea:RHEA:40919, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72841, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40920; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40432; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L- serine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phospho-L-serine + H(+); Xref=Rhea:RHEA:41752, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75020, ChEBI:CHEBI:75029; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41753; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; pH dependence: Optimum pH is 6.0-7.0. Secreted Cell membrane; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QZT4-1; Sequence=Displayed; Name=2; IsoId=Q9QZT4-2; Sequence=VSP_037525; Strongly expressed in testis. Strongly expressed during embryogenesis. Strongly up-regulated by lipopolysaccharide (LPS) in brain, heart, liver, colon and testis. [Isoform 2]: No signal peptide could be predicted in this isoform, challenging its subcellular location within the secretory pathway and hence the formation of disulfide bonds, which are required for its activity. Belongs to the phospholipase A2 family. immune system process phospholipase A2 activity calcium ion binding phospholipid binding extracellular region plasma membrane lipid metabolic process phospholipid metabolic process membrane lipid catabolic process hydrolase activity negative regulation of T cell proliferation innate immune response metal ion binding calcium-dependent phospholipase A2 activity arachidonic acid secretion uc008vlf.1 uc008vlf.2 uc008vlf.3 uc008vlf.4 
ENSMUST00000030528.9 Pla2g2d ENSMUST00000030528.9 phospholipase A2, group IID, transcript variant 1 (from RefSeq NM_011109.3) ENSMUST00000030528.1 ENSMUST00000030528.2 ENSMUST00000030528.3 ENSMUST00000030528.4 ENSMUST00000030528.5 ENSMUST00000030528.6 ENSMUST00000030528.7 ENSMUST00000030528.8 NM_011109 PA2GD_MOUSE Pla2a2 Q3V4B8 Q9JLK0 Q9WVF6 Splash uc008vlg.1 uc008vlg.2 uc008vlg.3 Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10531313, PubMed:23690440, PubMed:26392224, PubMed:10455175). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (PubMed:23690440). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (PubMed:23690440, PubMed:27226632). May act in an autocrine and paracrine manner. Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (PubMed:19564598). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1- acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+); Xref=Rhea:RHEA:44604, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:64381, ChEBI:CHEBI:64612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44605; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn- glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40911, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:73004, ChEBI:CHEBI:73007; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40912; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate; Xref=Rhea:RHEA:45472, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72829, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45473; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'- sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero- 3-phospho-(1'-sn-glycerol) + H(+); Xref=Rhea:RHEA:40919, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72841, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40920; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn- glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40812; Evidence=; Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)- docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41231, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:74963, ChEBI:CHEBI:77016; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41232; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; [Isoform 1]: Secreted Cell membrane Note=Localizes to cell membrane likely through binding to heparan sulfate proteoglycans. [Isoform 2]: Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WVF6-1; Sequence=Displayed; Name=2; IsoId=Q9WVF6-2; Sequence=VSP_004508; Highly expressed in secondary lymphoid tissues, spleen and lymph nodes. Expressed at a lesser extent in thymus (PubMed:11196711, PubMed:10455175, PubMed:10531313, PubMed:23690440). Expressed in CD4-positive, IL2RA/CD25-positive, FOXP3-positive Tregs (at protein level) (PubMed:19564598, PubMed:23690440). Expressed in myeloid cell subsets resident in spleen and lymph nodes, ITGAX/CD11C- positive dendritic cells and macrophages (at protein level). Enriched in CD4-positive, ITGAM/CD11B-positive dendritic cell subset (PubMed:19564598, PubMed:23690440). Expressed in pulmonary ITGAX/CD11C- positive dendritic cell subset (at protein level) (PubMed:26392224). Undetectable in embryonic spleens. Weak expression is detected the first week after birth, with further increase to normal levels by 4-6 weeks after birth. Up-regulated in thymus upon endotoxin challenge (PubMed:10455175). Up-regulated during Treg differention in response to TGFB1 (PubMed:19564598). Up-regulated in pulmonary ITGAX/CD11C-positive dendritic cell subset upon chronic oxidative stress associated with aging (PubMed:26392224). Knockout mice are born at the expected Mendelian rate and have normal embryonic and postnatal development (PubMed:23690440). They are susceptible to acute and chronic inflammatory reactions and resistant to tumorigenesis. In a model of hapten-induced contact hypersensitivity, mutant mice show an enhanced T-helper 1 immune response in skin lymph nodes at sensitization phase followed by delayed inflammation resolution with more severe ear swelling, epidermal hyperplasia, and inflammatory cell infiltration at elicitation phase (PubMed:23690440, PubMed:27226632). In a psoriasis model, mutant mice show enhanced T-helper 17 immune response and epidermal hyperplasia associated with decreased synthesis of omega-3 PUFAs (PubMed:27226632). In a model of chemically-induced skin carcinogenesis, mutant mice show resistance to cutaneous papilloma formation (PubMed:27226632). In response to SARS-CoV infection, mutant middle-aged (10-13 month old) mice mount a potent antiviral T cell response, resulting in more rapid virus clearance and significantly decreased mortality compared with wild-type ones. This represents a relevant model for SARS-CoV increased susceptibility with aging in human (PubMed:26392224). Belongs to the phospholipase A2 family. CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation phospholipase A2 activity calcium ion binding phospholipid binding extracellular region cytoplasm lipid metabolic process phospholipid metabolic process heparin binding lipid catabolic process hydrolase activity negative regulation of T cell proliferation heparan sulfate proteoglycan binding metal ion binding calcium-dependent phospholipase A2 activity arachidonic acid secretion negative regulation of T cell activation uc008vlg.1 uc008vlg.2 uc008vlg.3 
ENSMUST00000030531.14 Pla2g2e ENSMUST00000030531.14 phospholipase A2, group IIE (from RefSeq NM_012044.2) ENSMUST00000030531.1 ENSMUST00000030531.10 ENSMUST00000030531.11 ENSMUST00000030531.12 ENSMUST00000030531.13 ENSMUST00000030531.2 ENSMUST00000030531.3 ENSMUST00000030531.4 ENSMUST00000030531.5 ENSMUST00000030531.6 ENSMUST00000030531.7 ENSMUST00000030531.8 ENSMUST00000030531.9 NM_012044 PA2GE_MOUSE Q9QUL3 uc008vll.1 uc008vll.2 uc008vll.3 Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:11922621, PubMed:10531313). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), releasing various unsaturated fatty acids including oleoate, linoleoate, arachidonate, docosahexaenoate and lysophosphatidylethanolamines in preference to lysophosphatidylcholines (By similarity). In response to high-fat diet, hydrolyzes minor lipoprotein phospholipids including phosphatidylserines, phosphatidylinositols and phosphatidylglycerols, altering lipoprotein composition and fat storage in adipose tissue and liver (PubMed:24910243). May act in an autocrine and paracrine manner (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (By similarity). Acts as a hair follicle phospholipase A2. Selectively releases lysophosphatidylethanolamines (LPE) and various unsaturated fatty acids in skin to regulate hair follicle homeostasis (PubMed:27226633). May regulate the inflammatory response by releasing arachidonate, a precursor of prostaglandins and leukotrienes. Upon allergen exposure, may participate in allergic inflammatory response by enhancing leukotriene C4 synthesis and degranulation in mast cells (PubMed:11922621). Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1- acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+); Xref=Rhea:RHEA:44604, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:64381, ChEBI:CHEBI:64612; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn- glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40911, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:73004, ChEBI:CHEBI:73007; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40912; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40432; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate; Xref=Rhea:RHEA:45472, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72829, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45473; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoglycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn- glycero-3-phosphoglycerol + H(+); Xref=Rhea:RHEA:44524, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:84472, ChEBI:CHEBI:84475; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44525; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn- glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40812; Evidence=; Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)- docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41231, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:74963, ChEBI:CHEBI:77016; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41232; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 Ca(2+) ions per subunit. ; Secreted Cytoplasm Note=Through binding to heparan sulfate proteoglycan, may be localized to cytoplasmic compartments enriched in anionic phospholipids. Highly expressed in skin and uterus, and at lower levels in various other tissues (PubMed:27226633, PubMed:10531313, PubMed:10681567, PubMed:11922621). Expressed in hair follicles, specifically localized in companion cells of the outer root sheath and cuticular cells of the inner root sheath in hair follicles during anagen (PubMed:27226633). Expressed in white and brown adipose tissue (PubMed:24910243). Expressed abundantly in hair follicles during the anagen phase. Low expression is observed before birth, then follows hair cycle progression: up-regulated markedly during P5-P15 (anagen phase), declining to nearly the basal level during P20-P25 (catagen and telogen) and then increasing again at P30 (next anagen). Up-regulated in thymus, small intestine, brain, heart, testis, kidney and lung upon endotoxin challenge (PubMed:10681567, PubMed:11922621). Detected in alveolar macrophage-like cells upon endotoxin challenge (PubMed:10681567). Up-regulated in white and brown adipocytes upon high-fat diet (PubMed:24910243). Up-regulated in ear epidermis in response to topical dermatitis agent 2,4-dinitrobenzene (DNFB) (PubMed:11922621). Mutant mice show abnormal hair follicle ultrastructure characterized by defects in the companion layer, the inner root sheath (IRS) and hair shaft. Mutant IRS cells have large cytoplasmic cysts and pyknotic nuclei and are devoid of keratohyalin granules, whereas the cuticle is abnormally dissociated from the hair cortex and medulla, indicative of impaired hair follicle development (PubMed:27226633). Mutant mice are protected from obesity and hyperlipidemia in response to high-fat diet (PubMed:24910243). Belongs to the phospholipase A2 family. phospholipase A2 activity calcium ion binding phospholipid binding cellular_component extracellular region lipid metabolic process phospholipid metabolic process lipid catabolic process hydrolase activity low-density lipoprotein particle remodeling negative regulation of T cell proliferation metal ion binding calcium-dependent phospholipase A2 activity arachidonic acid secretion uc008vll.1 uc008vll.2 uc008vll.3 
ENSMUST00000030533.12 Vwa5b1 ENSMUST00000030533.12 von Willebrand factor A domain containing 5B1 (from RefSeq NM_029401.1) B1AZ81 B1AZ81_MOUSE ENSMUST00000030533.1 ENSMUST00000030533.10 ENSMUST00000030533.11 ENSMUST00000030533.2 ENSMUST00000030533.3 ENSMUST00000030533.4 ENSMUST00000030533.5 ENSMUST00000030533.6 ENSMUST00000030533.7 ENSMUST00000030533.8 ENSMUST00000030533.9 NM_029401 Vwa5b1 uc008vla.1 uc008vla.2 uc008vla.3 uc008vla.4 uc008vla.1 uc008vla.2 uc008vla.3 uc008vla.4 
ENSMUST00000030535.4 Cda ENSMUST00000030535.4 cytidine deaminase (from RefSeq NM_028176.1) CDD_MOUSE Cdd ENSMUST00000030535.1 ENSMUST00000030535.2 ENSMUST00000030535.3 NM_028176 P56389 Q9D7V3 uc008vkw.1 uc008vkw.2 uc008vkw.3 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Reaction=cytidine + H(+) + H2O = NH4(+) + uridine; Xref=Rhea:RHEA:16069, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:17562, ChEBI:CHEBI:28938; EC=3.5.4.5; Reaction=2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+); Xref=Rhea:RHEA:13433, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15698, ChEBI:CHEBI:16450, ChEBI:CHEBI:28938; EC=3.5.4.5; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Homotetramer. Belongs to the cytidine and deoxycytidylate deaminase family. nucleoside binding catalytic activity cytidine deaminase activity cytosol zinc ion binding cytidine deamination hydrolase activity negative regulation of cell growth identical protein binding protein homodimerization activity negative regulation of nucleotide metabolic process metal ion binding protein homotetramerization uc008vkw.1 uc008vkw.2 uc008vkw.3 
ENSMUST00000030536.13 Pink1 ENSMUST00000030536.13 PTEN induced putative kinase 1 (from RefSeq NM_026880.2) A2AM77 ENSMUST00000030536.1 ENSMUST00000030536.10 ENSMUST00000030536.11 ENSMUST00000030536.12 ENSMUST00000030536.2 ENSMUST00000030536.3 ENSMUST00000030536.4 ENSMUST00000030536.5 ENSMUST00000030536.6 ENSMUST00000030536.7 ENSMUST00000030536.8 ENSMUST00000030536.9 NM_026880 PINK1_MOUSE Q7TMZ3 Q811I8 Q91XU5 Q99MQ3 uc008vku.1 uc008vku.2 uc008vku.3 uc008vku.4 Serine/threonine-protein kinase which protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins such as PRKN and DNM1L, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:24652937, PubMed:24784582, PubMed:25474007, PubMed:32484300). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (By similarity). Mediates the translocation and activation of PRKN at the outer membrane (OMM) of dysfunctional/depolarized mitochondria (PubMed:24652937, PubMed:24784582, PubMed:25474007, PubMed:32484300). At the OMM of damaged mitochondria, phosphorylates pre-existing polyubiquitin chains at 'Ser-65', the PINK1-phosphorylated polyubiquitin then recruits PRKN from the cytosol to the OMM where PRKN is fully activated by phosphorylation at 'Ser-65' by PINK1 (PubMed:24652937, PubMed:24784582, PubMed:25474007, PubMed:32484300). In damaged mitochondria, mediates the decision between mitophagy or preventing apoptosis by promoting PRKN-dependent poly- or monoubiquitination of VDAC1; polyubiquitination of VDAC1 by PRKN promotes mitophagy, while monoubiquitination of VDAC1 by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (By similarity). When cellular stress results in irreversible mitochondrial damage, functions with PRKN to promote clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:24784582, PubMed:25474007). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by phosphorylating and thus promoting the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (By similarity). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (By similarity). Also promotes mitochondrial fission independently of PRKN and ATG7-mediated mitophagy, via the phosphorylation and activation of DNM1L (PubMed:32484300). Regulates motility of damaged mitochondria by promoting the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (By similarity). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (PubMed:24652937). Phosphorylates LETM1, positively regulating its mitochondrial calcium transport activity (PubMed:29123128). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Interacts with PRKN (By similarity). Interacts with FBXO7 (By similarity). Forms a complex with PRKN and PARK7 (PubMed:19229105). Interacts with NENF (PubMed:31536960). Mitochondrion outer membrane ; Single-pass membrane protein Mitochondrion inner membrane ; Single-pass membrane protein Cytoplasm, cytosol Note=Localizes mostly in mitochondrion and the two smaller proteolytic processed fragments localize mainly in cytosol. When mitochondria lose mitochondrial membrane potential following damage, PINK1 import is arrested, which induces its accumulation in the outer mitochondrial membrane, where it acquires kinase activity. High levels expressed in testis, lower levels in brain, heart, lung, liver and kidney. Proteolytically cleaved. In healthy cells, the precursor is continuously imported into the inner mitochondrial membrane (IMM), where it is proteolytically cleaved by mitochondrial-processing peptidase (MPP) and then undergoes further proteolytic cleavage by PARL or AFG3L2 to give rise to the 52 kDa short form. The 52 kDa short form is then released into the cytosol where it rapidly undergoes proteasome-dependent degradation. In unhealthy cells, when cellular stress conditions lead to the loss of mitochondrial membrane potential, mitochondrial import is impaired leading to the precursor accumulating on the outer mitochondrial membrane (OMM). If accumulation at the OMM fails and it is imported into the depolarized mitochondria, it undergoes cleavage by the IMM protease OMA1, promoting its subsequent degradation by the proteasome. Autophosphorylated (PubMed:25474007). Loss of mitochondrial membrane potential results in the precursor accumulating on the outer mitochondrial membrane (OMM) where it is activated by autophosphorylation (By similarity). Autophosphorylation at Ser-227 and Ser-401 is essential for selective recruitment of PRKN to depolarized mitochondria, via PINK1-dependent phosphorylation of ubiquitin and PRKN (By similarity). Mitochondrial dysfunction (PubMed:18687901, PubMed:20049710, PubMed:32484300). Mice do not show gross structural defects in mitochondria, although the number of larger mitochondria is selectively increased (PubMed:18687901, PubMed:32484300). Mitochondrial respiration is impaired in the striatum, which is rich in dopaminergic terminals, but not in the cerebral cortex in young mice (PubMed:18687901). Mitochondrial respiration activities in the cerebral cortex are decreased in 2 years old mice (PubMed:18687901). Mice show defects in mitochondrial complex I and a decrease in mitochondrial membrane potential (PubMed:20049710). Decreased phosphorylation of Dnm1l in embryonic fibroblasts and in the substantial nigra of 18 month old mice (PubMed:32484300). Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding magnesium ion binding mitophagy chromatin positive regulation of protein phosphorylation protease binding regulation of oxidative phosphorylation response to ischemia protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm mitochondrion mitochondrial outer membrane mitochondrial inner membrane mitochondrial intermembrane space cytosol cytoskeleton protein phosphorylation autophagy response to oxidative stress mitochondrion organization regulation of hydrogen peroxide metabolic process negative regulation of gene expression regulation of mitochondrion organization calcium-dependent protein kinase activity membrane integral component of membrane positive regulation of macroautophagy negative regulation of macroautophagy kinase activity phosphorylation protein ubiquitination transferase activity peptidyl-serine phosphorylation respiratory electron transport chain axon growth cone integral component of mitochondrial outer membrane regulation of protein ubiquitination ubiquitin protein ligase binding positive regulation of synaptic transmission, dopaminergic positive regulation of peptidyl-serine phosphorylation positive regulation of dopamine secretion positive regulation of catecholamine secretion cellular response to oxidative stress positive regulation of protein dephosphorylation intracellular signal transduction peptidyl-serine autophosphorylation negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly protein kinase B binding regulation of neuron apoptotic process negative regulation of neuron apoptotic process cell body macromolecular complex binding positive regulation of translation metal ion binding perinuclear region of cytoplasm protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity regulation of mitochondrial membrane potential C3HC4-type RING finger domain binding cellular response to hypoxia establishment of protein localization to mitochondrion maintenance of protein location in mitochondrion positive regulation of mitochondrial fission positive regulation of release of cytochrome c from mitochondria negative regulation of mitochondrial fission cellular response to toxic substance astrocyte projection mitophagy in response to mitochondrial depolarization mitochondrion to lysosome transport regulation of cellular response to oxidative stress negative regulation of neuron death positive regulation of histone deacetylase activity negative regulation of autophagosome assembly positive regulation of mitochondrial electron transport, NADH to ubiquinone negative regulation of mitophagy negative regulation of oxidative stress-induced cell death regulation of protein targeting to mitochondrion negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide positive regulation of cristae formation positive regulation of NMDA glutamate receptor activity TORC2 complex binding cellular response to hydrogen sulfide positive regulation of mitophagy in response to mitochondrial depolarization regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process negative regulation of intrinsic apoptotic signaling pathway uc008vku.1 uc008vku.2 uc008vku.3 uc008vku.4 
ENSMUST00000030538.5 Ddost ENSMUST00000030538.5 dolichyl-di-phosphooligosaccharide-protein glycotransferase (from RefSeq NM_007838.3) Ddost ENSMUST00000030538.1 ENSMUST00000030538.2 ENSMUST00000030538.3 ENSMUST00000030538.4 NM_007838 O54734 OST48_MOUSE Q8C4P7 uc008vkt.1 uc008vkt.2 uc008vkt.3 Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity). Protein modification; protein glycosylation. Component of the oligosaccharyltransferase (OST) complex (By similarity). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (By similarity). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with SMIM22 (By similarity). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Belongs to the DDOST 48 kDa subunit family. dolichyl-diphosphooligosaccharide-protein glycotransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation protein N-linked glycosylation oligosaccharyltransferase complex membrane integral component of membrane protein N-linked glycosylation via asparagine macromolecular complex response to cytokine T cell activation intracellular membrane-bounded organelle oligosaccharyl transferase activity uc008vkt.1 uc008vkt.2 uc008vkt.3 
ENSMUST00000030539.10 Kif17 ENSMUST00000030539.10 kinesin family member 17, transcript variant 1 (from RefSeq NM_010623.4) A2AM73 ENSMUST00000030539.1 ENSMUST00000030539.2 ENSMUST00000030539.3 ENSMUST00000030539.4 ENSMUST00000030539.5 ENSMUST00000030539.6 ENSMUST00000030539.7 ENSMUST00000030539.8 ENSMUST00000030539.9 KIF17_MOUSE NM_010623 Q99PW8 uc008vkq.1 uc008vkq.2 uc008vkq.3 uc008vkq.4 Dendrite-specific motor protein which, in association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. Homodimer (PubMed:10846156). Interacts with APBA1 (via PDZ domain); the interaction is direct and is required for association of KIF17 with the cargo that is to be transported (PubMed:10846156). Interacts with IFT B complex components IFT52 and IFT57 (PubMed:23810713). Interacts with IFT70B (PubMed:23810713). Interacts with PIWIL1 (PubMed:16787948). Interacts with TBATA (PubMed:17196196). Q99PW8; Q9Z0V2: Kcnd2; NbExp=3; IntAct=EBI-959754, EBI-959779; Cytoplasm, cytoskeleton Cell projection, cilium Cell projection, dendrite Note=Localizes to dendrites of pyramidal neurons (PubMed:10846156). Does not localize to the axons or nuclei in cerebral cortex, hippocampus or olfactory bulb (PubMed:10846156). Co- localizes with NR2B-containing vesicles along microtubules (PubMed:10846156). Highly expressed in the gray matter of the brain, especially in the hippocampus. Expressed from embryonic day 16, and expression increases to postnatal week 3. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding microtubule motor activity protein binding ATP binding cytoplasm cytoskeleton kinesin complex microtubule cilium axoneme microtubule-based process microtubule-based movement microtubule binding ATP-dependent microtubule motor activity, plus-end-directed protein transport microtubule cytoskeleton vesicle-mediated transport ATPase activity cell projection organization intraciliary transport particle B protein complex localization photoreceptor connecting cilium dendrite cytoplasm ciliary basal body intraciliary transport cell projection neuron projection anterograde dendritic transport of neurotransmitter receptor complex periciliary membrane compartment uc008vkq.1 uc008vkq.2 uc008vkq.3 uc008vkq.4 
ENSMUST00000030541.13 Hp1bp3 ENSMUST00000030541.13 heterochromatin protein 1, binding protein 3, transcript variant 17 (from RefSeq NR_185235.1) A2AM64 A2AM68 ENSMUST00000030541.1 ENSMUST00000030541.10 ENSMUST00000030541.11 ENSMUST00000030541.12 ENSMUST00000030541.2 ENSMUST00000030541.3 ENSMUST00000030541.4 ENSMUST00000030541.5 ENSMUST00000030541.6 ENSMUST00000030541.7 ENSMUST00000030541.8 ENSMUST00000030541.9 HP1B3_MOUSE NR_185235 Q3TEA8 Q3TM38 Q3TU07 Q61688 Q8BT17 Q8C6H2 Q8C911 Q8VE06 Q99KR0 Q9DBI1 uc008vkg.1 uc008vkg.2 uc008vkg.3 uc008vkg.4 uc008vkg.5 uc008vkg.6 Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis. Interacts (via PxVxL motif) with CBX5 (via Trp-174). Nucleus Chromosome Note=localized in nuclei but not in nucleoli in interphase. Colocalized with chromosomes in mitosis, with a gradually increased during G1 progression and a maximum level during late G1 phase (G1/S). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TEA8-1; Sequence=Displayed; Name=2; IsoId=Q3TEA8-2; Sequence=VSP_034175; Name=3; IsoId=Q3TEA8-3; Sequence=VSP_034174; A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA. Sequence=BAC35912.1; Type=Frameshift; Evidence=; nucleosome DNA binding chromatin binding nucleus chromosome nucleosome assembly regulation of transcription, DNA-templated nuclear speck nucleosome binding regulation of cell proliferation heterochromatin organization cellular response to hypoxia regulation of nucleus size uc008vkg.1 uc008vkg.2 uc008vkg.3 uc008vkg.4 uc008vkg.5 uc008vkg.6 
ENSMUST00000030551.11 Alpl ENSMUST00000030551.11 alkaline phosphatase, liver/bone/kidney, transcript variant 1 (from RefSeq NM_007431.3) Akp-2 Akp2 Alpl ENSMUST00000030551.1 ENSMUST00000030551.10 ENSMUST00000030551.2 ENSMUST00000030551.3 ENSMUST00000030551.4 ENSMUST00000030551.5 ENSMUST00000030551.6 ENSMUST00000030551.7 ENSMUST00000030551.8 ENSMUST00000030551.9 NM_007431 P09242 PPBT_MOUSE Q6P1B0 uc008vjr.1 uc008vjr.2 uc008vjr.3 uc008vjr.4 uc008vjr.5 This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a membrane-bound glycosylated enzyme that catalyzes the hydrolysis of phosphate esters at alkaline pH. The mature peptide maintains the ratio of inorganic phosphate to inorganic pyrophosphate required for bone mineralization. Mice that lack this enzyme show symptoms of osteomalacia, softening of the bones. In humans, mutations in this gene are associated with hypophosphatasia, an inherited metabolic bone disease in which deficiency of this enzyme inhibits bone mineralization leading to skeletal defects. Mutations in the mouse gene mirror the symptoms of human hypophosphatasia. A pseudogene of this gene is present on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis (PubMed:10620060, PubMed:11028439, PubMed:14982838, PubMed:23942722, PubMed:33981039). Has broad substrate specificity and can hydrolyze a considerable variety of compounds: however, only a few substrates, such as diphosphate (inorganic pyrophosphate; PPi), pyridoxal 5'-phosphate (PLP) and N-phosphocreatine are natural substrates (PubMed:19874193, PubMed:23942722, PubMed:33981039). Plays an essential role in skeletal and dental mineralization via its ability to hydrolyze extracellular diphosphate, a potent mineralization inhibitor, to phosphate: it thereby promotes hydroxyapatite crystal formation and increases inorganic phosphate concentration (PubMed:9056646, PubMed:10620060, PubMed:11004006, PubMed:11028439, PubMed:12082181, PubMed:14982838, PubMed:32035618). Acts in a non- redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (PubMed:20684022, PubMed:26457330). Also promotes dephosphorylation of osteopontin (SSP1), an inhibitor of hydroxyapatite crystallization in its phosphorylated state; it is however unclear whether ALPL/TNAP mediates SSP1 dephosphorylation via a direct or indirect manner (PubMed:23427088). Catalyzes dephosphorylation of PLP to pyridoxal (PL), the transportable form of vitamin B6, in order to provide a sufficient amount of PLP in the brain, an essential cofactor for enzymes catalyzing the synthesis of diverse neurotransmitters (PubMed:7550313). Additionally, also able to mediate ATP degradation in a stepwise manner to adenosine, thereby regulating the availability of ligands for purinergic receptors (PubMed:19874193, PubMed:23942722, PubMed:23825434, PubMed:32028019). Also capable of dephosphorylating microbial products, such as lipopolysaccharides (LPS) as well as other phosphorylated small-molecules, such as poly-inosine:cytosine (poly I:C) (By similarity). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating hydrolysis of N- phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation (PubMed:33981039). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (PubMed:33981039). Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.1; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15018; Evidence= Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24577; Evidence= Reaction=H2O + pyridoxal 5'-phosphate = phosphate + pyridoxal; Xref=Rhea:RHEA:20533, ChEBI:CHEBI:15377, ChEBI:CHEBI:17310, ChEBI:CHEBI:43474, ChEBI:CHEBI:597326; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20534; Evidence=; Reaction=H2O + phosphoethanolamine = ethanolamine + phosphate; Xref=Rhea:RHEA:16089, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57603, ChEBI:CHEBI:58190; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16090; Evidence=; Reaction=H2O + N-phosphocreatine = creatine + phosphate; Xref=Rhea:RHEA:12977, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57947, ChEBI:CHEBI:58092; EC=3.9.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12978; Evidence=; Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Reaction=ADP + H2O = AMP + H(+) + phosphate; Xref=Rhea:RHEA:61436, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61437; Evidence=; Reaction=AMP + H2O = adenosine + phosphate; Xref=Rhea:RHEA:29375, ChEBI:CHEBI:15377, ChEBI:CHEBI:16335, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29376; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Phosphatase activity is specifically inhibited by 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425). Homodimer. Cell membrane ; Lipid-anchor, GPI-anchor Extracellular vesicle membrane ipid-anchor, GPI-anchor Mitochondrion membrane ; Lipid-anchor, GPI-anchor Mitochondrion intermembrane space Note=Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells (PubMed:19874193, PubMed:23942722). Localizes to the mitochondria of thermogenic fat cells: tethered to mitochondrial membranes via a GPI-anchor and probably resides in the mitochondrion intermembrane space (PubMed:33981039). Widely expressed (PubMed:3478679). Expressed in DRG neurons and spinal cord neurons (PubMed:23825434). Not expressed prior to gastrulation in embryo, while it is expressed before in extraembryonic lineage cells destined to form the chorion (PubMed:7789278). Expressed in both embryonic and extraembryonic lineages during embryogenesis (PubMed:7789278). Expressed in early bell stage dental mesenchymal cells at 15.5 dpc (at protein level) (PubMed:24028588). Expressed in bell stage dental mesenchymal cells at 17.5 dpc (PubMed:29148101). By cold: up-regulated in response to cold both in brown and beige fat cells. Calcium-binding is structural and does not influence the alkaline phosphatase activity. At very high concentrations, calcium can however substitute for zinc at zinc-binding sites, leading to strongly reduced enzyme activity. N-glycosylated. Early death caused by defective metabolism of vitamin B6 (PubMed:7550313). At about two weeks of age, mice display seizures from which they die (PubMed:7550313, PubMed:9056646). Seizures are caused by a defect in the metabolism of pyridoxal 5'-phosphate (PLP) similar to that found in patients with hypophosphatasia, which ultimately results in a decrease in levels of 4-aminobutanoate (GABA) in the brain (PubMed:7550313). Mice do not show defects in skeletal formation during the first 8 days of life (PubMed:7550313, PubMed:10620060). Skeletal defects first appear at approximately 10 days of age and are characterized by worsening rachitic changes, osteopenia and fracture (PubMed:9056646, PubMed:10620060). Osteoblasts differentiate normally but are unable to initiate mineralization: histologic studies reveal developmental arrest of chondrocyte differentiation in epiphyses and in growth plates with diminished or absent hypertrophic zones (PubMed:10620060, PubMed:11028439). Mineral crystals are initiated within matrix vesicles (MVs) of the growth plate and bone; however, mineral crystal proliferation and growth is inhibited in the matrix surrounding MVs, as in the case with hypophosphatasia (PubMed:14982838). Progressive osteoidosis from defective skeletal matrix mineralization is observed but not associated with features of secondary hyperparathyroidism (PubMed:10620060). Abnormal vitamin B6 metabolism is not the cause of impaired bone mineralization (PubMed:11169525). An accumulation of substrates is observed, characterized by strong elevation of urinary diphosphate (PPi) and phosphoethanolamine (PEA) levels and a striking accumulation of plasma PLP (PubMed:10620060). Mice lacking both Phospho1 and Alpl show a complete absence of skeletal mineralization, leading to perinatal lethality (PubMed:20684022). Bone mineralization in mice lacking both Enpp1 and Alpl is essentially normal, demonstrating that Enpp1 and Alpl are antagonist key regulators of bone mineralization by determining the normal steady-state levels of diphosphate (PPi) (PubMed:12082181). Conditional deletion in adipocytes leads to defective adaptive thermogenesis: defects are caused by abolition of the futile creatine cycle, thereby reducing whole-body energy expenditure and leading to rapid-onset obesity in mice, with no change in movement or feeding behavior (PubMed:33981039). In most mammals there are four different isozymes: placental (ALPP), germ cell (ALPG), intestinal (ALPI) and tissue non- specific (liver/bone/kidney) (ALPL/TNAP). Belongs to the alkaline phosphatase family. endochondral ossification developmental process involved in reproduction catalytic activity alkaline phosphatase activity protein binding extracellular space plasma membrane membrane dephosphorylation pyrophosphatase activity hydrolase activity phosphatase activity extracellular matrix anchored component of membrane response to lipopolysaccharide response to vitamin D response to antibiotic metal ion binding response to glucocorticoid extracellular membrane-bounded organelle cellular response to organic cyclic compound cementum mineralization uc008vjr.1 uc008vjr.2 uc008vjr.3 uc008vjr.4 uc008vjr.5 
ENSMUST00000030556.8 Ptpn12 ENSMUST00000030556.8 protein tyrosine phosphatase, non-receptor type 12, transcript variant 2 (from RefSeq NM_011203.4) ENSMUST00000030556.1 ENSMUST00000030556.2 ENSMUST00000030556.3 ENSMUST00000030556.4 ENSMUST00000030556.5 ENSMUST00000030556.6 ENSMUST00000030556.7 NM_011203 P35831 PTN12_MOUSE Q80UM4 uc008woh.1 uc008woh.2 uc008woh.3 Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:17070019). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Interacts with PSTPIP1 and TGFB1I1 (PubMed:10092676, PubMed:11711533). Interacts with PTK2B/PYK2 (PubMed:12674328). Interacts with LPXN (PubMed:12674328, PubMed:15786712). Interacts with SORBS2; this interaction greatly enhances WASF1 dephosphorylation and might mediate partial translocation to focal adhesion sites (By similarity). P35831; P97814: Pstpip1; NbExp=5; IntAct=EBI-2642957, EBI-7484574; P35831; P98083: Shc1; NbExp=2; IntAct=EBI-2642957, EBI-300201; Cytoplasm ll junction, focal adhesion Cell projection, podosome Note=Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2. Phosphorylated by STK24/MST3 and this results in inhibition of its activity. Complete embryonic lethality at 9.5 to 10.5 dpc. Heterozygous mice have no obvious phenotype. Belongs to the protein-tyrosine phosphatase family. Non- receptor class 4 subfamily. podosome phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding cytoplasm cytosol focal adhesion protein dephosphorylation dephosphorylation hydrolase activity phosphatase activity SH3 domain binding cell junction peptidyl-tyrosine dephosphorylation regulation of epidermal growth factor receptor signaling pathway tissue regeneration cell projection cellular response to epidermal growth factor stimulus uc008woh.1 uc008woh.2 uc008woh.3 
ENSMUST00000030561.9 Gnat3 ENSMUST00000030561.9 G protein subunit alpha transducin 3 (from RefSeq NM_001081143.1) ENSMUST00000030561.1 ENSMUST00000030561.2 ENSMUST00000030561.3 ENSMUST00000030561.4 ENSMUST00000030561.5 ENSMUST00000030561.6 ENSMUST00000030561.7 ENSMUST00000030561.8 GNAT3_MOUSE NM_001081143 Q3V3I2 uc008wnr.1 uc008wnr.2 uc008wnr.3 Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP- phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. G proteins are composed of 3 units; alpha, beta and gamma, respectively GNAT3, GNB1 and GNG13 for Gustducin heterotrimer for bitter taste transduction. The alpha chain contains the guanine nucleotide binding site. Gustducin heterotrimer may also be composed of GNAT3, GNB3 and GNG13. Cytoplasm Expressed in taste buds (sensory organs of clustered epithelial cells) of the circumvallate and fungiform papillae of the tongue as well as in palatal taste buds at protein level. Expressed in enteroendocrine cells of the gut, such as in subsets of enteroendocrine cells in the midjejunum and brush cells. Detected also in spermatozoa. From week 1 to 7, the number of cells expressing GNAT3 in single taste buds increases within fungiform papilla; by week 7, the number reached the value found in adults. Expressed in cell bodies and axons of facial motor neurons at 10.5 dpc. Potential N-myristoylation may anchor alpha-subunit to the inner surface of plasma membrane. Mice are not affected in their tasting ability for salty (NaCl) and sour (HCl) stimuli, which are known not to be mediated by G proteins; but, they exhibit a significant reduction in the ability to taste the bitter compounds denatonium and quinine as well as the sweet compounds sucrose and SC45647, a guanidine sweetener. The incidence of cells responding to bitter stimulus is also reduced by seventy per cent. The residual behavioral response to bitter and sweet taste in these deficient mice suggests that there is alternative mechanism to compensate. However, transgenic expression of Gnat3 in these deficient mice restores responsiveness to both bitter and sweet compounds, whereas expression of mutated 'Gly-352' transgene do not. Furthermore, in wild-type mice, this mutated transgene acts as dominant-negative by inhibition of endogenous Gnat3 interactions with taste receptors. Mice show less preference for acesulfame-K, dulcin, fructose, D-phenylalanine, L-proline, D-tryptophan, saccharin, sweetener SC45647 and sucrose; Furthermore, in their gut, sugar or sweeteners do not increase SGLT1 expression and glucose-absorptive capacity compared to wild-type mice and the ingestion of glucose reveals deficiencies in secretion of GLP-1 and regulation of plasma insulin and glucose. Mice lacking GNAT3 show less preference for umami compounds such as monosodium glutamate (MSG) and no preference for inosine monophosphate (IMP) whereas wild-type mice strongly prefer IMP. The response to umami signals implicates the anteriorly placed taste buds of the tongue, and not the posterior part. Belongs to the G-alpha family. G(i/o/t/z) subfamily. nucleotide binding G-protein coupled receptor binding acrosomal vesicle GTPase activity GTP binding cytoplasm heterotrimeric G-protein complex axoneme signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway apical plasma membrane guanyl nucleotide binding G-protein beta/gamma-subunit complex binding macromolecular complex response to nicotine metal ion binding sensory perception of taste sensory perception of bitter taste sensory perception of sweet taste sensory perception of umami taste uc008wnr.1 uc008wnr.2 uc008wnr.3 
ENSMUST00000030568.14 Sema3c ENSMUST00000030568.14 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C (from RefSeq NM_013657.5) ENSMUST00000030568.1 ENSMUST00000030568.10 ENSMUST00000030568.11 ENSMUST00000030568.12 ENSMUST00000030568.13 ENSMUST00000030568.2 ENSMUST00000030568.3 ENSMUST00000030568.4 ENSMUST00000030568.5 ENSMUST00000030568.6 ENSMUST00000030568.7 ENSMUST00000030568.8 ENSMUST00000030568.9 NM_013657 Q62181 Q6NXW7 SEM3C_MOUSE SemE Semae uc008wnl.1 uc008wnl.2 uc008wnl.3 uc008wnl.4 Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance. Interacts with PLXND1. Secreted Expressed from day 10 in the embryo. Maximum expression between days 10-12 with moderate levels from day 13 until birth. Perinatal lethality. Mice display severe defects in cardiovascular development, including aortic arch malformations and septation defects in the cardiac outflow tract. Belongs to the semaphorin family. neural crest cell migration somitogenesis blood vessel remodeling outflow tract septum morphogenesis outflow tract morphogenesis cardiac right ventricle morphogenesis pulmonary myocardium development extracellular region extracellular space integral component of plasma membrane multicellular organism development nervous system development axon guidance heart development post-embryonic development neural tube development cell differentiation semaphorin receptor binding positive regulation of cell migration chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis limb bud formation dichotomous subdivision of terminal units involved in salivary gland branching semaphorin-plexin signaling pathway positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis uc008wnl.1 uc008wnl.2 uc008wnl.3 uc008wnl.4 
ENSMUST00000030578.14 Ptp4a2 ENSMUST00000030578.14 protein tyrosine phosphatase 4a2, transcript variant 9 (from RefSeq NR_188950.1) ENSMUST00000030578.1 ENSMUST00000030578.10 ENSMUST00000030578.11 ENSMUST00000030578.12 ENSMUST00000030578.13 ENSMUST00000030578.2 ENSMUST00000030578.3 ENSMUST00000030578.4 ENSMUST00000030578.5 ENSMUST00000030578.6 ENSMUST00000030578.7 ENSMUST00000030578.8 ENSMUST00000030578.9 NR_188950 O70274 Prl2 Q3U1K7 TP4A2_MOUSE uc008uyg.1 uc008uyg.2 uc008uyg.3 uc008uyg.4 Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Inhibited by sodium orthovanadate and pentamidine. In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB (By similarity). Cell membrane Early endosome Cytoplasm Expressed in skeletal muscle, and at lower levels in liver, lung, heart, kidney, brain, testis and spleen. Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB (By similarity). Belongs to the protein-tyrosine phosphatase family. phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm endosome early endosome plasma membrane protein dephosphorylation membrane dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc008uyg.1 uc008uyg.2 uc008uyg.3 uc008uyg.4 
ENSMUST00000030581.10 Azin2 ENSMUST00000030581.10 antizyme inhibitor 2, transcript variant 1 (from RefSeq NM_172875.4) A2A823 AZIN2_MOUSE Adc ENSMUST00000030581.1 ENSMUST00000030581.2 ENSMUST00000030581.3 ENSMUST00000030581.4 ENSMUST00000030581.5 ENSMUST00000030581.6 ENSMUST00000030581.7 ENSMUST00000030581.8 ENSMUST00000030581.9 NM_172875 Odcp Q8BVM4 uc008uvq.1 uc008uvq.2 uc008uvq.3 uc008uvq.4 The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]. Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:18062773, PubMed:18508777, PubMed:18973822). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:16916800, PubMed:24967154). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (By similarity). Monomer. Interacts with OAZ1, OAZ2 and OAZ3; this interaction disrupts the interaction between the antizyme and ODC1. Does not form a heterodimer with ODC1. Q8BVM4; Q9R109: Oaz3; NbExp=2; IntAct=EBI-9656869, EBI-4370103; Nucleus. Cytoplasm. Cytoplasm, perinuclear region Membrane. Cytoplasmic vesicle Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network Cytoplasmic granule. Cell projection, axon Cell projection, dendrite Perikaryon Note=Detected as vesicle-like pattern in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN). Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules (By similarity). Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in a antizyme- dependent manner. Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin- containing secretory granules. Expressed in the medulla and chromaffin cells of the adrenal gland. Expressed in the Langerhans islets of the pancreas. Expressed in the inner part of the seminiferous tubules and in spermatozoa located in the lumen of the epididymis of the testis. Expressed in the cortex, hippocampus and cerebellum of the brain. Expressed in normal and neoplastic mast cells (MC) (at protein level). Expressed in testis, pancreas and brain. Expressed throughout the differentiation process from spermatids to spermatozoa in the inner part of the seminiferous tubules. Expressed in the kidney: expressed in the superficial (Cs) and the deep layer (Cd) of the cortex region and in the outer stripe (OS), inner stripe (IS) and the inner medulla papilla (IM) of the medulla region. The N-terminus domain is necessary for its localization to the ER-Golgi intermediate compartment (ERGIC). Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteasomal-independent manner. Gly-70 is present instead of the conserved Lys which would otherwise be the covalent pyridoxal phosphate binding site. Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily. The human ortholog was initially reported to have ornithine or arginine decarboxylase activities, but it was later found to possess neither of them. Previously reported to be localized in the mitochondrion (PubMed:16916800). However, it was not confirmed by later reports (PubMed:18062773). catalytic activity protein binding nucleus cytoplasm mitochondrion endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cis-Golgi network trans-Golgi network ornithine metabolic process polyamine biosynthetic process putrescine transmembrane transporter activity putrescine transport membrane transport vesicle axon dendrite cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment membrane putrescine biosynthetic process from ornithine negative regulation of protein catabolic process ornithine decarboxylase activator activity cell projection positive regulation of catalytic activity perikaryon perinuclear region of cytoplasm trans-Golgi network membrane organization positive regulation of polyamine transmembrane transport granular vesicle ornithine decarboxylase activity arginine decarboxylase activity uc008uvq.1 uc008uvq.2 uc008uvq.3 uc008uvq.4 
ENSMUST00000030583.13 Ak2 ENSMUST00000030583.13 adenylate kinase 2, transcript variant 1 (from RefSeq NM_001033966.4) A2A820 ENSMUST00000030583.1 ENSMUST00000030583.10 ENSMUST00000030583.11 ENSMUST00000030583.12 ENSMUST00000030583.2 ENSMUST00000030583.3 ENSMUST00000030583.4 ENSMUST00000030583.5 ENSMUST00000030583.6 ENSMUST00000030583.7 ENSMUST00000030583.8 ENSMUST00000030583.9 KAD2_MOUSE NM_001033966 Q3THT3 Q3TI11 Q3TKI6 Q8C7I9 Q9CY37 Q9WTP6 uc008uvt.1 uc008uvt.2 uc008uvt.3 uc008uvt.4 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3; Evidence=; Monomer. Mitochondrion intermembrane space Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WTP6-1; Sequence=Displayed; Name=2; IsoId=Q9WTP6-2; Sequence=VSP_036504; Present in the inner ear. Not detected in the vestibule at any developmental stage. Present at high level in the cochlea uniquely in the stria vascularis at postnatal day 7 but not at birth. Present within the lumen of the stria vascularis capillaries. Not detected in the capillaries or vessels of the adjacent connective tissue (at protein level). Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Belongs to the adenylate kinase family. AK2 subfamily. nucleotide binding adenylate kinase activity ATP binding nucleus cytoplasm mitochondrion mitochondrial inner membrane mitochondrial intermembrane space cytosol nucleobase-containing compound metabolic process ADP biosynthetic process kinase activity phosphorylation transferase activity phosphotransferase activity, phosphate group as acceptor nucleobase-containing compound kinase activity sperm flagellum AMP metabolic process ATP metabolic process dATP metabolic process nucleoside monophosphate phosphorylation sperm mitochondrial sheath uc008uvt.1 uc008uvt.2 uc008uvt.3 uc008uvt.4 
ENSMUST00000030586.15 Ccdc28b ENSMUST00000030586.15 coiled coil domain containing 28B (from RefSeq NM_025455.2) A2ADZ9 CC28B_MOUSE ENSMUST00000030586.1 ENSMUST00000030586.10 ENSMUST00000030586.11 ENSMUST00000030586.12 ENSMUST00000030586.13 ENSMUST00000030586.14 ENSMUST00000030586.2 ENSMUST00000030586.3 ENSMUST00000030586.4 ENSMUST00000030586.5 ENSMUST00000030586.6 ENSMUST00000030586.7 ENSMUST00000030586.8 ENSMUST00000030586.9 NM_025455 Q8CEG5 Q8K132 uc008uxu.1 uc008uxu.2 uc008uxu.3 Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex. Interacts with BBS1, BBS2, BBS4, BBS5, BBS6, BBS7 and TTC8/BBS8. Interacts with MAPKAP1/SIN1 isoform 1 and RICTOR (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=It localizes near centrosomes and basal bodies. Expressed in the retina, pericardium and limb epithelium. molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton cell projection organization cilium assembly uc008uxu.1 uc008uxu.2 uc008uxu.3 
ENSMUST00000030606.14 Rcan3 ENSMUST00000030606.14 regulator of calcineurin 3, transcript variant 1 (from RefSeq NM_022980.5) Dscr1l2 ENSMUST00000030606.1 ENSMUST00000030606.10 ENSMUST00000030606.11 ENSMUST00000030606.12 ENSMUST00000030606.13 ENSMUST00000030606.2 ENSMUST00000030606.3 ENSMUST00000030606.4 ENSMUST00000030606.5 ENSMUST00000030606.6 ENSMUST00000030606.7 ENSMUST00000030606.8 ENSMUST00000030606.9 NM_022980 Q3U2I5 Q9CX87 Q9JKK0 RCAN3_MOUSE uc008vgm.1 uc008vgm.2 uc008vgm.3 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity). Interacts with protein phosphatase PPP3CA/calcineurin A. Belongs to the RCAN family. nucleic acid binding cytoplasm calcium-dependent protein serine/threonine phosphatase regulator activity calcium-mediated signaling phosphatase binding troponin I binding regulation of phosphoprotein phosphatase activity regulation of calcineurin-NFAT signaling cascade uc008vgm.1 uc008vgm.2 uc008vgm.3 
ENSMUST00000030610.3 Zbtb8a ENSMUST00000030610.3 zinc finger and BTB domain containing 8a (from RefSeq NM_028603.4) ENSMUST00000030610.1 ENSMUST00000030610.2 NM_028603 Q8VD30 Q9CWH1 ZBT8A_MOUSE uc008uww.1 uc008uww.2 uc008uww.3 May be involved in transcriptional regulation. Nucleus molecular_function nucleic acid binding DNA binding cellular_component nucleus biological_process metal ion binding uc008uww.1 uc008uww.2 uc008uww.3 
ENSMUST00000030614.3 CK137956 ENSMUST00000030614.3 cDNA sequence CK137956, transcript variant 2 (from RefSeq NM_001425125.1) B1AYM9 B1AYM9_MOUSE CK137956 ENSMUST00000030614.1 ENSMUST00000030614.2 NM_001425125 uc012dln.1 uc012dln.2 uc012dln.3 molecular_function cellular_component biological_process uc012dln.1 uc012dln.2 uc012dln.3 
ENSMUST00000030622.3 Syf2 ENSMUST00000030622.3 SYF2 homolog, RNA splicing factor (S. cerevisiae) (from RefSeq NM_026780.3) Cbpin ENSMUST00000030622.1 ENSMUST00000030622.2 Gcipip NM_026780 Q9D198 SYF2_MOUSE uc008vga.1 uc008vga.2 uc008vga.3 Involved in pre-mRNA splicing as component of the spliceosome. Identified in the spliceosome C complex. Interacts with CCNDBP1. Nucleus Abundantly expressed in the heart, liver and kidney. Expressed at lower level other tissues. Belongs to the SYF2 family. mRNA splicing, via spliceosome Prp19 complex in utero embryonic development nucleus spliceosomal complex mRNA processing mitotic G2 DNA damage checkpoint gastrulation positive regulation of cell proliferation RNA splicing nuclear speck embryonic organ development U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome post-mRNA release spliceosomal complex uc008vga.1 uc008vga.2 uc008vga.3 
ENSMUST00000030623.8 Sfpq ENSMUST00000030623.8 splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated), transcript variant 1 (from RefSeq NM_023603.3) A2A7U6 ENSMUST00000030623.1 ENSMUST00000030623.2 ENSMUST00000030623.3 ENSMUST00000030623.4 ENSMUST00000030623.5 ENSMUST00000030623.6 ENSMUST00000030623.7 NM_023603 Psf Q8VIJ6 Q9ERW2 SFPQ_MOUSE uc008utz.1 uc008utz.2 uc008utz.3 uc008utz.4 DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine- rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (By similarity). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (PubMed:21680841, PubMed:22966205). Required for the assembly of nuclear speckles (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity). Heterodimer with NONO. Monomer and component of the SFPQ-NONO complex, which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits. The coiled coil domain mediates interaction with NONO, and can also mediate formation of long, linear homooligomers (in vitro). SFPQ is a component of spliceosome and U5.4/6 snRNP complexes. Interacts with SNRPA/U1A. Component of a snRNP-free complex with SNRPA/U1A. Part of complex consisting of SFPQ, NONO and MATR3. Interacts with polypyrimidine tract-binding protein 1/PTB. Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with RXRA, probably THRA, and SIN3A. Interacts with TOP1. Part of a complex consisting of SFPQ, NONO and TOP1. Interacts with SNRNP70 in apoptotic cells. Interacts with PSPC1 (PubMed:15140795). Interacts with RNF43 (By similarity). Interacts with PITX3 and NR4A2/NURR1 (PubMed:19144721). Interacts with PTK6. Interacts with THRAP3; the interaction is dependent on SFPQ phosphorylation at 'Thr-687' and inhibits binding of SFPQ to a ESS1 exonic splicing silencer element-containing RNA (By similarity). The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A (PubMed:21680841). Interacts with PER1 and PER2 (PubMed:22966205). Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA (By similarity). Interacts with PQBP1. Component of a multiprotein complex with NONO and WASL (By similarity). Interacts with ERCC6 (By similarity). Q8VIJ6; O88609: Lmx1b; NbExp=5; IntAct=EBI-6094576, EBI-13951208; Q8VIJ6; Q8R326: Pspc1; NbExp=2; IntAct=EBI-6094576, EBI-309927; Nucleus speckle Nucleus matrix Cytoplasm Note=Predominantly in nuclear matrix. The coiled coil domain mediates interaction with NONO, and can also mediate formation of long, linear homooligomers (in vitro). The coiled coil domain is required for optimal DNA binding, and optimal transcription activation. Phosphorylated on multiple serine and threonine residues during apoptosis (By similarity). Phosphorylation of C-terminal tyrosines promotes its cytoplasmic localization, impaired its binding to polypyrimidine RNA and led to cell cycle arrest (By similarity). In resting T-cells is phosphorylated at Thr-679 by GSK3B which is proposed to promote association with THRAP and to prevent binding to PTPRC/CD45 pre-mRNA; T-cell activation leads to reduced phosphorylation at Thr- 679. negative regulation of transcription from RNA polymerase II promoter alternative mRNA splicing, via spliceosome double-strand break repair via homologous recombination chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding activation of innate immune response immune system process nucleic acid binding DNA binding chromatin binding RNA binding protein binding nucleus nucleoplasm cytoplasm DNA repair mRNA processing cellular response to DNA damage stimulus RNA splicing nuclear matrix nuclear speck dendrite cytoplasm paraspeckles regulation of circadian rhythm negative regulation of circadian rhythm protein homodimerization activity histone deacetylase binding transcription regulatory region DNA binding innate immune response positive regulation of sister chromatid cohesion negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process chromosome organization regulation of cell cycle E-box binding histone H3 deacetylation RNA polymerase II transcription factor complex dendritic transport of messenger ribonucleoprotein complex positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway uc008utz.1 uc008utz.2 uc008utz.3 uc008utz.4 
ENSMUST00000030626.12 Tmem50a ENSMUST00000030626.12 transmembrane protein 50A, transcript variant 1 (from RefSeq NM_027935.3) ENSMUST00000030626.1 ENSMUST00000030626.10 ENSMUST00000030626.11 ENSMUST00000030626.2 ENSMUST00000030626.3 ENSMUST00000030626.4 ENSMUST00000030626.5 ENSMUST00000030626.6 ENSMUST00000030626.7 ENSMUST00000030626.8 ENSMUST00000030626.9 NM_027935 Q9CXL1 Smp1 TM50A_MOUSE uc008vfv.1 uc008vfv.2 uc008vfv.3 Membrane ; Multi-pass membrane protein Belongs to the UPF0220 family. molecular_function cytoplasm endoplasmic reticulum membrane integral component of membrane late endosome to vacuole transport via multivesicular body sorting pathway neuronal cell body glial cell projection uc008vfv.1 uc008vfv.2 uc008vfv.3 
ENSMUST00000030627.8 Rhd ENSMUST00000030627.8 Rh blood group, D antigen, transcript variant 2 (from RefSeq NR_188963.1) A0A0R4J0A2 A0A0R4J0A2_MOUSE ENSMUST00000030627.1 ENSMUST00000030627.2 ENSMUST00000030627.3 ENSMUST00000030627.4 ENSMUST00000030627.5 ENSMUST00000030627.6 ENSMUST00000030627.7 NR_188963 Rhd uc008vft.1 uc008vft.2 uc008vft.3 Membrane ; Multi- pass membrane protein Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. ammonium transmembrane transporter activity ammonium transport membrane integral component of membrane ammonium transmembrane transport uc008vft.1 uc008vft.2 uc008vft.3 
ENSMUST00000030628.15 Maco1 ENSMUST00000030628.15 macoilin 1, transcript variant 1 (from RefSeq NM_025382.6) ENSMUST00000030628.1 ENSMUST00000030628.10 ENSMUST00000030628.11 ENSMUST00000030628.12 ENSMUST00000030628.13 ENSMUST00000030628.14 ENSMUST00000030628.2 ENSMUST00000030628.3 ENSMUST00000030628.4 ENSMUST00000030628.5 ENSMUST00000030628.6 ENSMUST00000030628.7 ENSMUST00000030628.8 ENSMUST00000030628.9 MACOI_MOUSE NM_025382 Q7TQE6 Tmem57 uc008vfq.1 uc008vfq.2 uc008vfq.3 uc008vfq.4 Plays a role in the regulation of neuronal activity. Rough endoplasmic reticulum membrane ; Multi-pass membrane protein Nucleus membrane ; Multi- pass membrane protein Note=Detected in the nucleus membrane of non-neuronal cells and in axonal outgrowths of neuronal cells (PubMed:15255972). Strong expression in whole nervous system up to 12.5 dpc. Highly expressed in all neuronal differentiation fields from 14.5 dpc to birth, with highest expression in the telencephalic cortical plate and mitral cells in the olfactory bulb, and lower expression in neuronal progenitor zones. Progressively decreased expression in fields of neuron precursor proliferation from 14.5 dpc and virtually undetectable there by 17.5 dpc. No significant expression detected outside the nervous system. After birth, significant expression remains in the cerebellum, olfactory bulb and hippocampus. In the embryo, stronger expression at 15.5 dpc than at 10.5 dpc or 19.5 dpc. Expression decreases after birth although significant expression remains associated with some neuronal structures at P10. Belongs to the macoilin family. nucleus endoplasmic reticulum chemotaxis brain development microtubule binding membrane integral component of membrane neuronal signal transduction axon rough endoplasmic reticulum membrane nuclear membrane neuron projection neuron projection terminus synapse actin filament binding uc008vfq.1 uc008vfq.2 uc008vfq.3 uc008vfq.4 
ENSMUST00000030636.11 Stmn1 ENSMUST00000030636.11 stathmin 1 (from RefSeq NM_019641.4) ENSMUST00000030636.1 ENSMUST00000030636.10 ENSMUST00000030636.2 ENSMUST00000030636.3 ENSMUST00000030636.4 ENSMUST00000030636.5 ENSMUST00000030636.6 ENSMUST00000030636.7 ENSMUST00000030636.8 ENSMUST00000030636.9 NM_019641 Q545B6 Q545B6_MOUSE Stmn1 uc008vfc.1 uc008vfc.2 uc008vfc.3 Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST. Cytoplasm, cytoskeleton Belongs to the stathmin family. mitotic cytokinesis microtubule depolymerization mitotic spindle organization brain development response to virus tubulin binding regulation of microtubule polymerization or depolymerization negative regulation of microtubule polymerization negative regulation of Rho protein signal transduction hepatocyte growth factor receptor signaling pathway negative regulation of stress fiber assembly establishment of skin barrier negative regulation of thrombin-activated receptor signaling pathway negative regulation of guanyl-nucleotide exchange factor activity uc008vfc.1 uc008vfc.2 uc008vfc.3 
ENSMUST00000030637.14 Ncdn ENSMUST00000030637.14 neurochondrin, transcript variant 1 (from RefSeq NM_011986.5) ENSMUST00000030637.1 ENSMUST00000030637.10 ENSMUST00000030637.11 ENSMUST00000030637.12 ENSMUST00000030637.13 ENSMUST00000030637.2 ENSMUST00000030637.3 ENSMUST00000030637.4 ENSMUST00000030637.5 ENSMUST00000030637.6 ENSMUST00000030637.7 ENSMUST00000030637.8 ENSMUST00000030637.9 Kiaa0607 NCDN_MOUSE NM_011986 Q3TCW4 Q80TW1 Q91YH7 Q9CW81 Q9QUQ0 Q9Z0E0 Sfap75 uc008utt.1 uc008utt.2 uc008utt.3 uc008utt.4 Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. Interacts with MCHR1 (By similarity). Interacts with SEMA4C (PubMed:11162505). Interacts with DIAPH1 (via FH3 domain) (PubMed:18572016). Interacts with GRM5 (By similarity). Cytoplasm, cytosol Endosome membrane ; Lipid-anchor Cell projection, dendrite Postsynapse Note=Localizes to somatic regions of neurons. Localization to endosome membrane requires palmitoylation. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Neurochondrin-1; IsoId=Q9Z0E0-1; Sequence=Displayed; Name=2; Synonyms=Neurochondrin-2; IsoId=Q9Z0E0-2; Sequence=VSP_032317; Expressed in the neuronal, chondral and bone tissues. Expressed in dendrites. Enriched in the brain in the surface layer I-IV. In brains, protein level increases in male but decreases in female with advancing age (at protein level). In adult brains, it is highly expressed in the forebrain and hindbrain. Highly expressed in the hippocampus, piriform cortex, septum, amygdaloid complex, medial geniculate nucleus, inferior colliculus, cerebellar nuclei and the nuclei of the Vth, VIIth, and XIIth cranial nerves. In bone tissues, it is expressed in osteoblasts and osteocytes. In the developing brain, it is first expressed in the hindbrain and spinal cord at 10.5 dpc followed by expression in the midbrain at 11.5 dpc. By 18 dpc it is also expressed in the diencephalon and telencephalon, with a strongest expression in the hindbrain. Highly expressed in the developing olfactory bulb and in the lateral choroid plexus. Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7. Death between 3.5 and 6.5 dpc. Heterozygous mutant do not display gross anatomic abnormalities. They however show abnormalities in developing cartilage. Nervous system-specific gene disruption by conditional knockout results in epileptic seizure. Displays no overt neurite outgrowth phenotype (PubMed:15790563). Shows a behavioral phenotype associated with a rodent model of schizophrenia, as observed in alterations in both sensorimotor gating and psychotomimetic-induced locomotor activity. Belongs to the neurochondrin family. protein binding cytoplasm cytosol dendrite neuron projection development cell projection neuron projection neuronal cell body bone resorption regulation of neuronal synaptic plasticity nucleus axon uc008utt.1 uc008utt.2 uc008utt.3 uc008utt.4 
ENSMUST00000030642.3 Psmb2 ENSMUST00000030642.3 proteasome (prosome, macropain) subunit, beta type 2, transcript variant 1 (from RefSeq NM_011970.5) ENSMUST00000030642.1 ENSMUST00000030642.2 NM_011970 PSB2_MOUSE Q9R1P3 uc008utr.1 uc008utr.2 uc008utr.3 uc008utr.4 Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Cytoplasm Nucleus Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. Detected in liver (at protein level). Belongs to the peptidase T1B family. proteasome complex endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteolysis peptidase activity response to organonitrogen compound proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process response to organic cyclic compound hydrolase activity proteasome core complex, beta-subunit complex proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process uc008utr.1 uc008utr.2 uc008utr.3 uc008utr.4 
ENSMUST00000030643.3 Extl1 ENSMUST00000030643.3 exostosin-like glycosyltransferase 1, transcript variant 1 (from RefSeq NM_019578.2) E9QKA3 ENSMUST00000030643.1 ENSMUST00000030643.2 EXTL1_MOUSE NM_019578 Q9JKV7 uc012dmu.1 uc012dmu.2 uc012dmu.3 Glycosyltransferase required for the biosynthesis of heparan- sulfate (HS). Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity). Appears to lack GlcNAcT I and GlcAT-II activities. Reaction=3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)- beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L- seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D- GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl- [protein] + H(+) + UDP; Xref=Rhea:RHEA:16213, Rhea:RHEA-COMP:12621, Rhea:RHEA-COMP:12623, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:132415, ChEBI:CHEBI:132416; EC=2.4.1.224; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 47 family. Name=Functional Glycomics Gateway - GTase; Note=EXTL1 (putative HS transferase) [GAG Enzyme]; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_578"; endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus protein glycosylation acetylglucosaminyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity uc012dmu.1 uc012dmu.2 uc012dmu.3 
ENSMUST00000030644.8 Zfp593 ENSMUST00000030644.8 zinc finger protein 593 (from RefSeq NM_024215.2) ENSMUST00000030644.1 ENSMUST00000030644.2 ENSMUST00000030644.3 ENSMUST00000030644.4 ENSMUST00000030644.5 ENSMUST00000030644.6 ENSMUST00000030644.7 NM_024215 Q3UZX2 Q99J54 Q9DB42 ZN593_MOUSE Znf593 uc008vej.1 uc008vej.2 uc008vej.3 Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome. Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Associates with pre-60S ribosomal particles. Nucleus, nucleolus Cytoplasm Note=Shuttles between the nucleus and the cytoplasm. The protein is largely disordered, with the exception of the zinc finger domain. Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family. Sequence=AAH03465.1; Type=Erroneous initiation; Evidence=; Sequence=BAB23902.1; Type=Erroneous initiation; Evidence=; ribosomal large subunit export from nucleus nucleic acid binding DNA binding nucleus nucleolus zinc ion binding preribosome, large subunit precursor ribosomal large subunit binding positive regulation of transcription from RNA polymerase II promoter metal ion binding negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding uc008vej.1 uc008vej.2 uc008vej.3 
ENSMUST00000030645.9 Cnksr1 ENSMUST00000030645.9 connector enhancer of kinase suppressor of Ras 1 (from RefSeq NM_001081047.1) A2A9K7 A2A9K7_MOUSE Cnksr1 ENSMUST00000030645.1 ENSMUST00000030645.2 ENSMUST00000030645.3 ENSMUST00000030645.4 ENSMUST00000030645.5 ENSMUST00000030645.6 ENSMUST00000030645.7 ENSMUST00000030645.8 NM_001081047 uc008vei.1 uc008vei.2 uc008vei.3 Belongs to the CNKSR family. cell cortex Ras protein signal transduction Rho protein signal transduction protein binding, bridging uc008vei.1 uc008vei.2 uc008vei.3 
ENSMUST00000030651.9 Sh3bgrl3 ENSMUST00000030651.9 SH3 domain binding glutamic acid-rich protein-like 3 (from RefSeq NM_080559.2) ENSMUST00000030651.1 ENSMUST00000030651.2 ENSMUST00000030651.3 ENSMUST00000030651.4 ENSMUST00000030651.5 ENSMUST00000030651.6 ENSMUST00000030651.7 ENSMUST00000030651.8 NM_080559 Q91VW3 SH3L3_MOUSE uc008vec.1 uc008vec.2 uc008vec.3 Could act as a modulator of glutaredoxin biological activity (By similarity). May play a role in cytoskeleton organization (By similarity). Homodimer (PubMed:15120624). Interacts with MYO1C (via its IQ motifs); the interaction is dependent on calcium and takes place at membrane ruffles (By similarity). Cytoplasm, cytosol Cell projection, ruffle membrane Nucleus May be glycosylated. Belongs to the SH3BGR family. nucleus cytoplasm electron carrier activity protein disulfide oxidoreductase activity nuclear body electron transport chain cell redox homeostasis oxidation-reduction process uc008vec.1 uc008vec.2 uc008vec.3 
ENSMUST00000030660.9 Trappc3 ENSMUST00000030660.9 trafficking protein particle complex 3 (from RefSeq NM_013718.2) ENSMUST00000030660.1 ENSMUST00000030660.2 ENSMUST00000030660.3 ENSMUST00000030660.4 ENSMUST00000030660.5 ENSMUST00000030660.6 ENSMUST00000030660.7 ENSMUST00000030660.8 NM_013718 Q3U9K9 Q3U9K9_MOUSE Trappc3 uc008utc.1 uc008utc.2 uc008utc.3 May play a role in vesicular transport from endoplasmic reticulum to Golgi. Homodimer. Golgi apparatus, cis-Golgi network Belongs to the TRAPP small subunits family. BET3 subfamily. endoplasmic reticulum Golgi apparatus cytosol vesicle-mediated transport TRAPP complex Golgi vesicle transport uc008utc.1 uc008utc.2 uc008utc.3 
ENSMUST00000030661.14 Gpn2 ENSMUST00000030661.14 GPN-loop GTPase 2, transcript variant 1 (from RefSeq NM_133884.2) A2A9E9 Atpbd1b ENSMUST00000030661.1 ENSMUST00000030661.10 ENSMUST00000030661.11 ENSMUST00000030661.12 ENSMUST00000030661.13 ENSMUST00000030661.2 ENSMUST00000030661.3 ENSMUST00000030661.4 ENSMUST00000030661.5 ENSMUST00000030661.6 ENSMUST00000030661.7 ENSMUST00000030661.8 ENSMUST00000030661.9 GPN2_MOUSE Gpn2 NM_133884 Q8VEJ1 uc008vdb.1 uc008vdb.2 uc008vdb.3 uc008vdb.4 Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. Heterodimers with GPN1 or GPN3. Binds to RNA polymerase II (RNAPII). Belongs to the GPN-loop GTPase family. nucleotide binding GTPase activity GTP binding hydrolase activity uc008vdb.1 uc008vdb.2 uc008vdb.3 uc008vdb.4 
ENSMUST00000030662.3 Gpatch3 ENSMUST00000030662.3 G patch domain containing 3 (from RefSeq NM_172876.2) A2A9E8 ENSMUST00000030662.1 ENSMUST00000030662.2 GPTC3_MOUSE Gpatc3 NM_172876 Q8BIY1 uc008vda.1 uc008vda.2 uc008vda.3 Involved in transcriptional regulation. It is able to activate transcription from CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6. Interacts with mitochondrial MAVS; the interaction is markedly increased upon viral infection. Nucleus Cytoplasm molecular_function nucleic acid binding nucleus cytoplasm negative regulation of type I interferon production negative regulation of RIG-I signaling pathway positive regulation of transcription, DNA-templated uc008vda.1 uc008vda.2 uc008vda.3 
ENSMUST00000030665.7 Nudc ENSMUST00000030665.7 nudC nuclear distribution protein (from RefSeq NM_010948.3) ENSMUST00000030665.1 ENSMUST00000030665.2 ENSMUST00000030665.3 ENSMUST00000030665.4 ENSMUST00000030665.5 ENSMUST00000030665.6 NM_010948 NUDC_MOUSE O35685 Q3UJS7 uc012dmm.1 uc012dmm.2 uc012dmm.3 Plays a role in neurogenesis and neuronal migration (PubMed:11734602). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity). Necessary for cytokinesis and cell proliferation (By similarity). Interacts with PLK1 (By similarity). Interacts with PAFAH1B1 (PubMed:9601647). Part of a complex containing PLK1, NUDC, dynein and dynactin (PubMed:11734602). Interacts with DCDC1 (By similarity). Interacts with EML4 (via WD repeats) (By similarity). O35685; Q61768: Kif5b; NbExp=4; IntAct=EBI-911192, EBI-776129; O35685; Q61206: Pafah1b2; NbExp=2; IntAct=EBI-911192, EBI-7445518; Cytoplasm, cytoskeleton Nucleus Cytoplasm, cytoskeleton, spindle Midbody Note=A small proportion is nuclear, in a punctate pattern (By similarity). In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells (By similarity). Localizes to the mitotic spindle in a EML4-dependent manner (By similarity). Detected in fetal and adult brain, in particular in the ventricular zone of the embryonic forebrain and in the embryonic cortical plate. Highly expressed in brain cortex from new born and adult mice. Detected in the choroid plexus and in ependymal cells in embryonic brain. Up-regulated in silica-treated macrophages. Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-275 and Ser-327 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases (By similarity). Belongs to the nudC family. protein binding nucleus cytoplasm Golgi apparatus cytosol cytoskeleton microtubule protein folding cell cycle nuclear migration developmental process unfolded protein binding cell division uc012dmm.1 uc012dmm.2 uc012dmm.3 
ENSMUST00000030669.8 Slc9a1 ENSMUST00000030669.8 solute carrier family 9 (sodium/hydrogen exchanger), member 1, transcript variant 1 (from RefSeq NM_016981.3) ENSMUST00000030669.1 ENSMUST00000030669.2 ENSMUST00000030669.3 ENSMUST00000030669.4 ENSMUST00000030669.5 ENSMUST00000030669.6 ENSMUST00000030669.7 NM_016981 Nhe1 Q61165 SL9A1_MOUSE uc008vcs.1 uc008vcs.2 uc008vcs.3 Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (By similarity). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (By similarity). Reaction=H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out); Xref=Rhea:RHEA:29419, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101; Evidence=; Reaction=H(+)(in) + Li(+)(out) = H(+)(out) + Li(+)(in); Xref=Rhea:RHEA:72407, ChEBI:CHEBI:15378, ChEBI:CHEBI:49713; Evidence=; Reaction=Li(+)(in) + Na(+)(out) = Li(+)(out) + Na(+)(in); Xref=Rhea:RHEA:72415, ChEBI:CHEBI:29101, ChEBI:CHEBI:49713; Evidence=; Activated at acidic pHs. Inhibited by cariporide and eniporide. Inhibited by amiloride and 5-amino-substituted derivatives. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) bind and differentially regulate SLC9A1 activity. Homodimer; dimerization is crucial for its function (By similarity). Oligomer (By similarity). Interacts with CALM1 in a calcium-dependent manner (By similarity). Interacts with TESC (By similarity). Interacts (via the juxtamembrane region of the cytoplasmic C-terminal domain) with CHP1; the interaction occurs at the plasma membrane in a calcium-dependent manner (By similarity). Interacts with CHP2; the interaction occurs in a calcium-dependent manner (By similarity). Interacts with EZR; regulates the cytoskeletal interactions of SLC9A1 and promotes stress fiber formation (By similarity). Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Note=Localized basolaterally in every epithelial cell, except in the choroid plexus where SLC9A1 is expressed luminally. Expressed in kidney, brain and stomach. O-glycosylated. Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1. Palmitoylated; may play a major role in SLC9A1 regulation. Phosphorylation at Thr-784 increases SLC9A1 activity. Specifically dephosphorylated at Thr-784 by PPP3CA that negatively regulates SLC9A1 activity. Phosphorylation at Ser-652 by AKT1 reduces SLC9A1 binding to CALM1. Note=Defects in Slc9a1 is the cause of slow-wave epilepsy (swe) phenotype (PubMed:9335342). Mutant mice display slow-wave epilepsy, with a neurological syndrome including ataxia and a unique epilepsy phenotype consisting of 3/sec absence and tonic-clonic seizures. Mutants show selective neuronal death in the cerebellum and brainstem. Mice display also several other significant abnormalities in growth and development, and less than half of the mutant homozygous animals survived to weaning. Most died by 35-40 days (PubMed:9335342). Deficient mice exhibit a decreased rate of postnatal growth that is first evident at 2 week of age. At this time, deficient animals also begin to exhibit ataxia and epileptic-like seizures. Approximately 67% of the mutants die before weaning. Predicted models used for more than 20 years predicted 10-12 transmembrane segments. Recently, the stucture of SLC9A1 has been solved and reveals that SLC9A1 posseses 13 transmembranes. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. The interacting region with TESC is conflicting: In human, it has been reported that SLC9A1 interacts with TESC via the juxtamembrane region of the cytoplasmic C-terminal domain, including residues 507- 549. However, another publication has reported interaction with TESC via residues 637-820, the region of the cytoplasmic C-terminus more distal to the membrane. regulation of the force of heart contraction calmodulin binding nucleoplasm cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane ion transport cation transport sodium ion transport cellular sodium ion homeostasis regulation of pH cell surface response to acidic pH positive regulation of cardiac muscle hypertrophy regulation of cardiac muscle contraction by calcium ion signaling response to organic cyclic compound intercalated disc antiporter activity solute:proton antiporter activity sodium:proton antiporter activity potassium:proton antiporter activity membrane integral component of membrane basolateral plasma membrane apical plasma membrane cell differentiation positive regulation of cell growth T-tubule protein phosphatase 2B binding cellular response to insulin stimulus positive regulation of mitochondrial membrane permeability response to muscle stretch sodium ion export from cell sarcolemma positive regulation of apoptotic process negative regulation of apoptotic process membrane raft positive regulation of action potential positive regulation of transcription from RNA polymerase II promoter calcium-dependent protein binding perinuclear region of cytoplasm protein oligomerization regulation of intracellular pH regulation of sensory perception of pain cardiac muscle cell differentiation transmembrane transport cellular response to cold positive regulation of calcineurin-NFAT signaling cascade neuron death cellular response to antibiotic cellular response to electrical stimulus cellular response to organic cyclic compound cellular response to hypoxia cellular response to acidic pH potassium ion transmembrane transport cellular response to epinephrine stimulus cardiac muscle cell contraction regulation of the force of heart contraction by cardiac conduction cation-transporting ATPase complex anion transmembrane transport sodium ion import across plasma membrane positive regulation of the force of heart contraction positive regulation of intracellular signal transduction hydrogen ion transmembrane transport positive regulation of calcium:sodium antiporter activity uc008vcs.1 uc008vcs.2 uc008vcs.3 
ENSMUST00000030674.8 Sytl1 ENSMUST00000030674.8 synaptotagmin-like 1 (from RefSeq NM_031393.2) A2AE94 A2AE94_MOUSE ENSMUST00000030674.1 ENSMUST00000030674.2 ENSMUST00000030674.3 ENSMUST00000030674.4 ENSMUST00000030674.5 ENSMUST00000030674.6 ENSMUST00000030674.7 NM_031393 Sytl1 uc012dmk.1 uc012dmk.2 uc012dmk.3 plasma membrane intracellular protein transport exocytosis Rab GTPase binding uc012dmk.1 uc012dmk.2 uc012dmk.3 
ENSMUST00000030675.8 Mrps15 ENSMUST00000030675.8 mitochondrial ribosomal protein S15 (from RefSeq NM_025544.2) ENSMUST00000030675.1 ENSMUST00000030675.2 ENSMUST00000030675.3 ENSMUST00000030675.4 ENSMUST00000030675.5 ENSMUST00000030675.6 ENSMUST00000030675.7 NM_025544 Q7TMG9 Q8C7F1 Q9CVE0 Q9CWX1 Q9DC71 RT15_MOUSE Rpms15 uc008usg.1 uc008usg.2 uc008usg.3 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins (By similarity). Interacts with METTL17 (PubMed:31487196). Mitochondrion matrix Belongs to the universal ribosomal protein uS15 family. structural constituent of ribosome nucleus nucleolus mitochondrion mitochondrial ribosome mitochondrial small ribosomal subunit ribosome translation mitochondrial translation uc008usg.1 uc008usg.2 uc008usg.3 
ENSMUST00000030676.8 Grik3 ENSMUST00000030676.8 glutamate receptor, ionotropic, kainate 3 (from RefSeq NM_001081097.3) B1AS29 ENSMUST00000030676.1 ENSMUST00000030676.2 ENSMUST00000030676.3 ENSMUST00000030676.4 ENSMUST00000030676.5 ENSMUST00000030676.6 ENSMUST00000030676.7 GRIK3_MOUSE Glur7 NM_001081097 Q17R20 Q9JIA8 uc008usa.1 uc008usa.2 uc008usa.3 uc008usa.4 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Transcript variants encoding different isoforms have been described for this gene, however, their full-length nature is not known. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data from rat and human. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity). Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity). Interacts with NETO2 (By similarity). Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi- pass membrane protein Detected in whole brain, cerebellum, brain cortex and hippocampus. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily. adenylate cyclase inhibiting G-protein coupled glutamate receptor activity ionotropic glutamate receptor activity ion channel activity protein binding plasma membrane integral component of plasma membrane ion transport adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway glutamate receptor activity ligand-gated ion channel activity kainate selective glutamate receptor activity membrane integral component of membrane cell junction axon dendrite dendrite cytoplasm kainate selective glutamate receptor complex ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic signaling receptor activity regulation of membrane potential presynaptic membrane terminal bouton perikaryon synapse postsynaptic membrane modulation of synaptic transmission negative regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential postsynaptic density membrane glutamatergic synapse regulation of presynaptic membrane potential ligand-gated ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc008usa.1 uc008usa.2 uc008usa.3 uc008usa.4 
ENSMUST00000030677.7 Map3k6 ENSMUST00000030677.7 mitogen-activated protein kinase kinase kinase 6 (from RefSeq NM_016693.5) A0A0A0MQ82 A0A0A0MQ82_MOUSE ENSMUST00000030677.1 ENSMUST00000030677.2 ENSMUST00000030677.3 ENSMUST00000030677.4 ENSMUST00000030677.5 ENSMUST00000030677.6 Map3k6 NM_016693 uc008vck.1 uc008vck.2 uc008vck.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. MAPK cascade nucleotide binding activation of MAPKK activity magnesium ion binding protein kinase activity MAP kinase kinase kinase activity ATP binding protein phosphorylation kinase activity phosphorylation transferase activity uc008vck.1 uc008vck.2 uc008vck.3 
ENSMUST00000030684.8 Gnl2 ENSMUST00000030684.8 guanine nucleotide binding protein nucleolar 2 (from RefSeq NM_145552.2) B1ASC3 ENSMUST00000030684.1 ENSMUST00000030684.2 ENSMUST00000030684.3 ENSMUST00000030684.4 ENSMUST00000030684.5 ENSMUST00000030684.6 ENSMUST00000030684.7 NM_145552 NOG2_MOUSE Q8BIF8 Q99LH1 uc008uro.1 uc008uro.2 uc008uro.3 uc008uro.4 GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels. Interacts with LYAR and RPL23A. Interacts with the nuclear importin-beta receptor and, at a lower extent, with importin-alpha. Nucleus, nucleolus Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. nucleotide binding GTP binding nucleus nucleolus ribosome biogenesis uc008uro.1 uc008uro.2 uc008uro.3 uc008uro.4 
ENSMUST00000030687.8 Rspo1 ENSMUST00000030687.8 R-spondin 1 (from RefSeq NM_138683.2) B1ASC1 B1ASC1_MOUSE ENSMUST00000030687.1 ENSMUST00000030687.2 ENSMUST00000030687.3 ENSMUST00000030687.4 ENSMUST00000030687.5 ENSMUST00000030687.6 ENSMUST00000030687.7 NM_138683 Rspo1 uc008urn.1 uc008urn.2 Belongs to the R-spondin family. G-protein coupled receptor binding positive regulation of protein phosphorylation regulation of receptor internalization receptor binding positive regulation of Wnt signaling pathway positive regulation of canonical Wnt signaling pathway uc008urn.1 uc008urn.2 
ENSMUST00000030691.17 Pclo ENSMUST00000030691.17 piccolo (presynaptic cytomatrix protein), transcript variant 1 (from RefSeq NM_011995.4) Acz E9QK94 ENSMUST00000030691.1 ENSMUST00000030691.10 ENSMUST00000030691.11 ENSMUST00000030691.12 ENSMUST00000030691.13 ENSMUST00000030691.14 ENSMUST00000030691.15 ENSMUST00000030691.16 ENSMUST00000030691.2 ENSMUST00000030691.3 ENSMUST00000030691.4 ENSMUST00000030691.5 ENSMUST00000030691.6 ENSMUST00000030691.7 ENSMUST00000030691.8 ENSMUST00000030691.9 NM_011995 PCLO_MOUSE Pclo Q8CF91 Q8CF92 Q9QYX6 Q9QYX7 Q9QZJ0 uc008wmi.1 uc008wmi.2 uc008wmi.3 Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:19812333). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (PubMed:28231469) (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per C2 domain. Interacts with BSN, ERC2/CAST1, RIMS1 and UNC13A (PubMed:10508862, PubMed:12401793). Interacts (via C-terminus) with TRIO (via N-terminus) (By similarity). Interacts with CTBP1 (By similarity). Interacts with SIAH1; this interaction negatively regulates SIAH1 E3 ligase activity (By similarity). Directly interacts with GIT1 and GIT2 (By similarity). Presynaptic active zone Note=Colocalizes with BSN in developing axons. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=L; IsoId=Q9QYX7-1; Sequence=Displayed; Name=2; Synonyms=S; IsoId=Q9QYX7-2; Sequence=VSP_003928, VSP_003929; Highly expressed in brain. Moderately expressed in pituitary gland and pancreatic islets. Low levels found in stomach. C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change. Knockdown of both Bassoon/BSN and Piccolo/PCLO leads to the formation of presynaptic autophagosomes. Sequence=BAC53723.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Several sequence problems.; Evidence=; Sequence=BAC53724.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Several sequence problems.; Evidence=; Sequence=CAB60731.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=CAB60732.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; transcription corepressor binding calcium ion binding protein binding profilin binding calcium-dependent phospholipid binding Golgi-associated vesicle trans-Golgi network cytoskeleton organization synapse assembly postsynaptic density synaptic vesicle targeting regulation of exocytosis cAMP-mediated signaling cell junction insulin secretion transport vesicle axon dendrite growth cone neuromuscular junction protein localization to synapse neuron projection neuronal cell body terminal bouton cone cell pedicle rod spherule synapse metal ion binding perinuclear region of cytoplasm presynaptic active zone cytoskeleton of presynaptic active zone maintenance of presynaptic active zone structure synapse organization inhibitory synapse synaptic vesicle clustering ribbon synapse presynaptic active zone cytoplasmic component structural constituent of presynaptic active zone glutamatergic synapse presynapse to nucleus signaling pathway presynaptic active zone assembly regulation of ubiquitin protein ligase activity uc008wmi.1 uc008wmi.2 uc008wmi.3 
ENSMUST00000030693.13 Fgr ENSMUST00000030693.13 FGR proto-oncogene, Src family tyrosine kinase (from RefSeq NM_010208.4) ENSMUST00000030693.1 ENSMUST00000030693.10 ENSMUST00000030693.11 ENSMUST00000030693.12 ENSMUST00000030693.2 ENSMUST00000030693.3 ENSMUST00000030693.4 ENSMUST00000030693.5 ENSMUST00000030693.6 ENSMUST00000030693.7 ENSMUST00000030693.8 ENSMUST00000030693.9 FGR_MOUSE NM_010208 P14234 Q61404 Q8BGM0 uc012dmj.1 uc012dmj.2 uc012dmj.3 uc012dmj.4 Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes (PubMed:11672534). Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages (PubMed:8666673, PubMed:9687507). Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation (PubMed:15561106). Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling (PubMed:21746961). Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (PubMed:16439675). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Activated by autophosphorylation. Prior phosphorylation at Tyr-511 by SRC inhibits ulterior autophosphorylation at Tyr-400. Activated by phorbol myristate acetate, phosphatidic acid and poly-Lys. Binding (via SH2 domain) of HCLS1 that is already phosphorylated by SYK strongly increases kinase activity. Interacts with ITGB1, ITGB2, MS4A2/FCER1B, FCER1G and FCGR2. Interacts (via SH2 domain) with SYK (tyrosine phosphorylated). Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with PTK2/FAK1. Interacts (via SH2 domain) with HCLS1 (tyrosine phosphorylated by SYK). Interacts with SIRPA and PTPNS1. Interacts (not phosphorylated on tyrosine residues) with CBL; FGR tyrosine phosphorylation promotes dissociation (By similarity). Interacts with CLNK (PubMed:16439675). P14234; Q9QZE2: Clnk; NbExp=3; IntAct=EBI-7587024, EBI-8040679; Cell membrane ; Lipid-anchor ; Cytoplasmic side Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, ruffle membrane Cytoplasm, cytosol Cytoplasm, cytoskeleton Mitochondrion inner membrane Mitochondrion intermembrane space Note=Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. Expressed in natural killer cells (at protein level). Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation (By similarity). Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2 engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-511 by SRC inhibits ulterior autophosphorylation at Tyr-400 (By similarity). No visible phenotype. Mice lacking both Fgr and Hck are normal and fertile, but show increased susceptibility to infection with Listeria monocytogenes. In addition, their polymorphonuclear leukocytes show defects in cell spreading and adhesion. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. nucleotide binding phosphotyrosine binding immune system process protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding cytoplasm mitochondrion mitochondrial inner membrane mitochondrial intermembrane space cytosol cytoskeleton plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway integrin-mediated signaling pathway regulation of cell shape positive regulation of phosphatidylinositol 3-kinase signaling membrane aggresome kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation protein kinase binding cell differentiation bone mineralization positive regulation of cell migration extrinsic component of cytoplasmic side of plasma membrane ruffle membrane negative regulation of natural killer cell activation regulation of actin cytoskeleton organization immunoglobulin receptor binding Fc-gamma receptor I complex binding peptidyl-tyrosine autophosphorylation regulation of cell proliferation cell projection positive regulation of mast cell degranulation positive regulation of phosphatidylinositol 3-kinase activity innate immune response regulation of innate immune response regulation of protein kinase activity protein autophosphorylation skeletal system morphogenesis positive regulation of cytokine secretion regulation of phagocytosis defense response to Gram-positive bacterium actin cytoskeleton uc012dmj.1 uc012dmj.2 uc012dmj.3 uc012dmj.4 
ENSMUST00000030696.11 Fam76a ENSMUST00000030696.11 family with sequence similarity 76, member A, transcript variant 1 (from RefSeq NM_145553.3) A2ADS2 ENSMUST00000030696.1 ENSMUST00000030696.10 ENSMUST00000030696.2 ENSMUST00000030696.3 ENSMUST00000030696.4 ENSMUST00000030696.5 ENSMUST00000030696.6 ENSMUST00000030696.7 ENSMUST00000030696.8 ENSMUST00000030696.9 FA76A_MOUSE NM_145553 Q3U3U8 Q3V3N2 Q922G2 uc008vbz.1 uc008vbz.2 uc008vbz.3 uc008vbz.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q922G2-1; Sequence=Displayed; Name=2; IsoId=Q922G2-2; Sequence=VSP_019773; Belongs to the FAM76 family. nucleoplasm uc008vbz.1 uc008vbz.2 uc008vbz.3 uc008vbz.4 
ENSMUST00000030698.5 Stx12 ENSMUST00000030698.5 syntaxin 12 (from RefSeq NM_133887.4) ENSMUST00000030698.1 ENSMUST00000030698.2 ENSMUST00000030698.3 ENSMUST00000030698.4 NM_133887 Q3UIV9 Q921T9 Q9ER00 STX12_MOUSE uc008vbx.1 uc008vbx.2 uc008vbx.3 SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Associates with the BLOC-1 complex. Interacts with BLOC1S6. Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Interacts with GRIPAP1 (PubMed:20098723). Forms a complex with GRIP1, GRIA2 and NSG1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). Interacts with NSG1 (PubMed:12070131). Interacts with TPC1 (PubMed:28855648). Interacts (via N-terminus) with VPS13B (By similarity). Endosome membrane ; Single-pass type IV membrane protein Golgi apparatus membrane ; Single-pass type IV membrane protein Endomembrane system ; Single-pass type IV membrane protein ; Cytoplasmic side Early endosome membrane ; Single-pass type IV membrane protein Recycling endosome membrane ; Single-pass type IV membrane protein Belongs to the syntaxin family. autophagosome assembly Golgi membrane SNARE binding pre-autophagosomal structure SNAP receptor activity protein binding endosome Golgi apparatus intracellular protein transport vesicle fusion synaptic vesicle endosome membrane endomembrane system protein transport membrane integral component of membrane synaptic vesicle to endosome fusion vesicle-mediated transport integral component of synaptic vesicle membrane BLOC-1 complex SNARE complex early endosome membrane vesicle cholesterol efflux membrane raft phagocytic vesicle vesicle docking protein stabilization recycling endosome membrane postsynaptic recycling endosome uc008vbx.1 uc008vbx.2 uc008vbx.3 
ENSMUST00000030702.14 Ppp1r8 ENSMUST00000030702.14 protein phosphatase 1, regulatory subunit 8, transcript variant 1 (from RefSeq NM_146154.3) ENSMUST00000030702.1 ENSMUST00000030702.10 ENSMUST00000030702.11 ENSMUST00000030702.12 ENSMUST00000030702.13 ENSMUST00000030702.2 ENSMUST00000030702.3 ENSMUST00000030702.4 ENSMUST00000030702.5 ENSMUST00000030702.6 ENSMUST00000030702.7 ENSMUST00000030702.8 ENSMUST00000030702.9 NM_146154 Nipp1 PP1R8_MOUSE Q8C087 Q8R3G1 uc008vbw.1 uc008vbw.2 uc008vbw.3 uc008vbw.4 uc008vbw.5 Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre- mRNA splicing. Binds DNA and might act as a transcriptional repressor. Essential for cell proliferation and early embryonic development. Interacts with phosphorylated CDC5L, SF3B1 and MELK. Part of the spliceosome. Interacts with PPP1CA, PPP1CB and PPP1CC (By similarity). Interacts with EED. Part of a complex consisting of PPP1R8, EED, HDAC2 and PP-1. Nucleus Nucleus speckle Note=Mainly, but not exclusively, nuclear. Has a basic N- and C-terminal and an acidic central domain. The FHA domain mediates interactions with threonine- phosphorylated MELK. May be inactivated by phosphorylation on Ser-199 or Ser-204. Mice display a retarded growth and embryonic lethality at E6.5, due to defects in proliferation rate. DNA binding RNA binding mRNA binding protein phosphatase inhibitor activity protein serine/threonine phosphatase inhibitor activity nucleus nucleoplasm spliceosomal complex mRNA processing multicellular organism development cell proliferation RNA splicing nuclear speck protein phosphatase regulator activity negative regulation of phosphoprotein phosphatase activity negative regulation of protein dephosphorylation regulation of phosphoprotein phosphatase activity uc008vbw.1 uc008vbw.2 uc008vbw.3 uc008vbw.4 uc008vbw.5 
ENSMUST00000030709.9 Smpdl3b ENSMUST00000030709.9 sphingomyelin phosphodiesterase, acid-like 3B (from RefSeq NM_133888.2) ENSMUST00000030709.1 ENSMUST00000030709.2 ENSMUST00000030709.3 ENSMUST00000030709.4 ENSMUST00000030709.5 ENSMUST00000030709.6 ENSMUST00000030709.7 ENSMUST00000030709.8 NM_133888 Q3TLX9 Q3TLX9_MOUSE Smpdl3b uc008vbs.1 uc008vbs.2 uc008vbs.3 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) per subunit. ; Secreted Belongs to the acid sphingomyelinase family. sphingomyelin phosphodiesterase activity extracellular region extracellular space sphingomyelin catabolic process phosphoric diester hydrolase activity hydrolase activity metal ion binding uc008vbs.1 uc008vbs.2 uc008vbs.3 
ENSMUST00000030724.9 Sesn2 ENSMUST00000030724.9 sestrin 2 (from RefSeq NM_144907.1) ENSMUST00000030724.1 ENSMUST00000030724.2 ENSMUST00000030724.3 ENSMUST00000030724.4 ENSMUST00000030724.5 ENSMUST00000030724.6 ENSMUST00000030724.7 ENSMUST00000030724.8 NM_144907 P58043 SESN2_MOUSE Sesn2 uc008vbj.1 uc008vbj.2 uc008vbj.3 uc008vbj.4 Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25259925). In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling (PubMed:18692468, PubMed:25259925). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:18692468, PubMed:25259925). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses (By similarity). May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed (By similarity). Reaction=a hydroperoxide + L-cysteinyl-[protein] = an alcohol + S- hydroxy-L-cysteinyl-[protein]; Xref=Rhea:RHEA:67124, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:17193, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:61973; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67125; Evidence=; Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by leucine (By similarity). Conveys leucine availability via direct interaction with SEH1L and WDR24 components of the GATOR2 complex (By similarity). Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them (PubMed:25259925). May interact with the TORC2 complex (PubMed:25377878). Interacts with KEAP1, RBX1, SQSTM and ULK1; to regulate the degradation of KEAP1 (PubMed:25040165). May also associate with the complex composed of TSC1, TSC2 and the AMP-responsive protein kinase/AMPK to regulate TORC1 signaling (PubMed:18692468). May interact with PRDX1 (By similarity). Cytoplasm Detected in heart, liver and skeletal muscles (at protein level). Up-regulated by treatments inducing endoplasmic reticulum stress. The N-terminal domain has an alkylhydroperoxide reductase activity. The C-terminal domain mediates interaction with GATOR2 through which it regulates TORC1 signaling. Phosphorylated by ULK1 at multiple sites. Ubiquitinated at Lys-175 by RNF167 via 'Lys-63'-linked polyubiquitination in response to leucine deprivation: ubiquitination promotes SESN2-interaction with the GATOR2 complex, leading to inhibit the TORC1 signaling pathway. Deubiquitinated at Lys-175 by STAMBPL1, promoting the TORC1 signaling pathway. Ubiquitinated by RNF186; ubiquitination mediates proteasomal degradation. Sesn2 knockout mice are fully viable and do not display any overt developmental abnormalities. When kept on high fat diet, they display higher insulin resistance and glucose intolerance (PubMed:22958918). The oxidative stress induced by acute lipogenesis upon refeeding results in increased liver damages in the Sesn2 knockout mice. Any condition, like obesity, that triggers chronic or acute endoplasmic reticulum stresses have the same consequences in these mice and can lead to liver fibrosis (PubMed:23274085, PubMed:24947615). Sesn2 and Sesn3 double knockout mice display insulin resistance and glucose intolerance (PubMed:22958918). Triple knockout mice lacking Sesn1, Sesn2 and Sesn3 do not display an embryonic lethal phenotype since they are born at an expected Mendelian ratio. Moreover, they are not distinguishable from their wild-type littermates. However, their survival at 10 days is dramatically affected. This is associated with a constitutive activation of TORC1 signaling in the liver, heart and skeletal muscle during postnatal fasting, that occurs between birth and suckling (PubMed:25259925). Belongs to the sestrin family. regulation of protein phosphorylation GDP-dissociation inhibitor activity protein binding nucleus cytoplasm mitochondrion regulation of gluconeogenesis fatty acid beta-oxidation mitochondrion organization response to glucose positive regulation of macroautophagy oxidoreductase activity oxidoreductase activity, acting on peroxide as acceptor negative regulation of cell growth DNA damage response, signal transduction by p53 class mediator mitochondrial DNA metabolic process sulfiredoxin activity response to insulin cellular response to amino acid starvation cellular response to oxidative stress positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress cellular response to glucose starvation glucose homeostasis protein kinase B signaling glucose import peroxiredoxin activity oxidation-reduction process GATOR2 complex triglyceride homeostasis leucine binding cellular response to amino acid stimulus cellular response to leucine reactive oxygen species metabolic process cellular oxidant detoxification positive regulation of protein localization to nucleus regulation of response to reactive oxygen species negative regulation of translation in response to endoplasmic reticulum stress negative regulation of TORC1 signaling positive regulation of lipophagy cellular response to leucine starvation ATG1/ULK1 kinase complex regulation of cAMP-dependent protein kinase activity nucleotide-activated protein kinase complex TORC2 complex uc008vbj.1 uc008vbj.2 uc008vbj.3 uc008vbj.4 
ENSMUST00000030730.14 Trnau1ap ENSMUST00000030730.14 tRNA selenocysteine 1 associated protein 1 (from RefSeq NM_027925.3) ENSMUST00000030730.1 ENSMUST00000030730.10 ENSMUST00000030730.11 ENSMUST00000030730.12 ENSMUST00000030730.13 ENSMUST00000030730.2 ENSMUST00000030730.3 ENSMUST00000030730.4 ENSMUST00000030730.5 ENSMUST00000030730.6 ENSMUST00000030730.7 ENSMUST00000030730.8 ENSMUST00000030730.9 NM_027925 Q05DN9 Q4FZE9 Q7TMM7 Q80VC6 Secp43 TSAP1_MOUSE Trspap1 uc008vbb.1 uc008vbb.2 Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis. Found in a complex with tRNA(Sec) (By similarity). Interacts with SEPSECS (By similarity). Component of the tRNA(Sec) complex composed at least of EEFSEC, SECISBP2, SEPHS1, SEPSECS, TRNAU1AP and tRNA(Sec). Associates with mRNP and/or polysomes. Nucleus. Cytoplasm. Note=Abundant in the nucleus. Belongs to the RRM TRSPAP family. tRNA binding selenocysteine incorporation nucleic acid binding RNA binding protein binding nucleus cytoplasm translation uc008vbb.1 uc008vbb.2 
ENSMUST00000030731.11 Taf12 ENSMUST00000030731.11 TATA-box binding protein associated factor 12 (from RefSeq NM_025579.3) ENSMUST00000030731.1 ENSMUST00000030731.10 ENSMUST00000030731.2 ENSMUST00000030731.3 ENSMUST00000030731.4 ENSMUST00000030731.5 ENSMUST00000030731.6 ENSMUST00000030731.7 ENSMUST00000030731.8 ENSMUST00000030731.9 NM_025579 Q3V0S7 Q8VE65 Q9CZ11 Q9D8Q0 TAF12_MOUSE uc008vax.1 uc008vax.2 uc008vax.3 uc008vax.4 uc008vax.5 uc008vax.6 The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP- associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, SUPT3H, TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, STAF65-gamma/SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Interacts with ATF7 (via the transactivation domain); the interaction is prevented by sumoylation of ATF7. Nucleus Belongs to the TAF12 family. SAGA complex PCAF complex DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity histone acetyltransferase activity protein binding nucleus transcription factor TFIID complex DNA-templated transcription, initiation transcription initiation from RNA polymerase II promoter transcription factor binding TBP-class protein binding STAGA complex transcription factor TFTC complex histone H3 acetylation SLIK (SAGA-like) complex protein heterodimerization activity positive regulation of sequence-specific DNA binding transcription factor activity RNA polymerase II transcriptional preinitiation complex assembly positive regulation of nucleic acid-templated transcription uc008vax.1 uc008vax.2 uc008vax.3 uc008vax.4 uc008vax.5 uc008vax.6 
ENSMUST00000030734.5 Sf3a3 ENSMUST00000030734.5 splicing factor 3a, subunit 3, transcript variant 2 (from RefSeq NR_185053.1) ENSMUST00000030734.1 ENSMUST00000030734.2 ENSMUST00000030734.3 ENSMUST00000030734.4 NR_185053 Q9D554 SF3A3_MOUSE Sap61 uc008uqx.1 uc008uqx.2 uc008uqx.3 uc008uqx.4 Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre- mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre- catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes. Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Part of the SF3A subcomplex of the 17S U2 SnRNP complex which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62 and SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the mature 17S U2 small nuclear ribonucleoprotein complex (17S U2 snRNP). Identified in the spliceosome 'E' complex, a precursor of the spliceosome 'A' complex. Identified in the spliceosome 'A' and 'B' complexes. Identified in the spliceosome 'C' complex. Nucleus speckle Nucleus Belongs to the SF3A3 family. mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus nucleoplasm spliceosomal complex U2 snRNP mRNA processing zinc ion binding RNA splicing nuclear speck metal ion binding U2-type precatalytic spliceosome catalytic step 2 spliceosome U2-type prespliceosome assembly uc008uqx.1 uc008uqx.2 uc008uqx.3 uc008uqx.4 
ENSMUST00000030738.8 Utp11 ENSMUST00000030738.8 UTP11 small subunit processome component, transcript variant 7 (from RefSeq NR_185024.1) ENSMUST00000030738.1 ENSMUST00000030738.2 ENSMUST00000030738.3 ENSMUST00000030738.4 ENSMUST00000030738.5 ENSMUST00000030738.6 ENSMUST00000030738.7 NR_185024 Q3UI21 Q9CVB5 Q9CZJ1 UTP11_MOUSE Utp11l uc008uqu.1 uc008uqu.2 uc008uqu.3 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus Belongs to the UTP11 family. extracellular space nucleus nucleolus cytoplasm rRNA processing nervous system development small-subunit processome positive regulation of apoptotic process uc008uqu.1 uc008uqu.2 uc008uqu.3 
ENSMUST00000030741.9 Ptpru ENSMUST00000030741.9 protein tyrosine phosphatase receptor type U, transcript variant 2 (from RefSeq NM_001083119.3) B1AUH1 ENSMUST00000030741.1 ENSMUST00000030741.2 ENSMUST00000030741.3 ENSMUST00000030741.4 ENSMUST00000030741.5 ENSMUST00000030741.6 ENSMUST00000030741.7 ENSMUST00000030741.8 NM_001083119 O35564 P70125 PTPRU_MOUSE Pcp2 Ptpf Q3V312 Q66JV9 uc008vaa.1 uc008vaa.2 uc008vaa.3 Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Forms homooligomeric complexes which mediate cell homotypic adhesion (Probable). Interacts (via the cytoplasmic juxtamembrane domain) with CTNNB1; may mediate interaction with the cadherin/catenin adhesion complex. Interacts with KIT (By similarity). May interact with AP3B1 (By similarity). Cell junction Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B1AUH1-1; Sequence=Displayed; Name=2; IsoId=B1AUH1-2; Sequence=VSP_037086; Transcripts of different sizes are differentially expressed in a subset of tissues. Detected in brain, lung, skeletal muscle, heart, kidney and placenta. In brain; expressed in olfactory bulb, cerebral cortex, hippocampus and cerebellum. Expressed throughout embryonic development. First detected at 7 dpc. The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain. In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed (By similarity). N-glycosylated. Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated (By similarity). Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. Sequence=AAH80736.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=AAH80736.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAE43351.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; phosphoprotein phosphatase activity protein tyrosine phosphatase activity plasma membrane cell-cell junction protein dephosphorylation cell adhesion beta-catenin binding negative regulation of cell proliferation membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity cell junction cell differentiation negative regulation of cell migration animal organ regeneration homotypic cell-cell adhesion protein localization to cell surface peptidyl-tyrosine dephosphorylation response to glucocorticoid negative regulation of canonical Wnt signaling pathway positive regulation of cell-cell adhesion mediated by cadherin uc008vaa.1 uc008vaa.2 uc008vaa.3 
ENSMUST00000030742.11 Mecr ENSMUST00000030742.11 mitochondrial trans-2-enoyl-CoA reductase, transcript variant 8 (from RefSeq NR_188988.1) ENSMUST00000030742.1 ENSMUST00000030742.10 ENSMUST00000030742.2 ENSMUST00000030742.3 ENSMUST00000030742.4 ENSMUST00000030742.5 ENSMUST00000030742.6 ENSMUST00000030742.7 ENSMUST00000030742.8 ENSMUST00000030742.9 MECR_MOUSE NR_188988 Nrbf1 Q99L39 Q9DCS3 uc008vae.1 uc008vae.2 uc008vae.3 uc008vae.4 Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (By similarity). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (PubMed:30266742). Reaction=a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH; Xref=Rhea:RHEA:22564, Rhea:RHEA-COMP:9925, Rhea:RHEA- COMP:9926, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78784, ChEBI:CHEBI:78785; EC=1.3.1.104; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22566; Evidence=; Reaction=(2E)-butenoyl-[ACP] + H(+) + NADPH = butanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41812, Rhea:RHEA-COMP:9627, Rhea:RHEA-COMP:9628, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78453, ChEBI:CHEBI:78454; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41813; Evidence=; Reaction=(2E)-hexenoyl-[ACP] + H(+) + NADPH = hexanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41832, Rhea:RHEA-COMP:9631, Rhea:RHEA-COMP:9632, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78458, ChEBI:CHEBI:78459; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41833; Evidence=; Reaction=(2E)-octenoyl-[ACP] + H(+) + NADPH = NADP(+) + octanoyl-[ACP]; Xref=Rhea:RHEA:41848, Rhea:RHEA-COMP:9635, Rhea:RHEA-COMP:9636, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78462, ChEBI:CHEBI:78463; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41849; Evidence=; Reaction=(2E)-decenoyl-[ACP] + H(+) + NADPH = decanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41864, Rhea:RHEA-COMP:9639, Rhea:RHEA-COMP:9640, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78467, ChEBI:CHEBI:78468; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41865; Evidence=; Reaction=(2E)-dodecenoyl-[ACP] + H(+) + NADPH = dodecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41880, Rhea:RHEA-COMP:9643, Rhea:RHEA- COMP:9644, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:65264, ChEBI:CHEBI:78472; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41881; Evidence=; Reaction=(2E)-tetradecenoyl-[ACP] + H(+) + NADPH = NADP(+) + tetradecanoyl-[ACP]; Xref=Rhea:RHEA:41896, Rhea:RHEA-COMP:9647, Rhea:RHEA-COMP:9648, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78475, ChEBI:CHEBI:78477; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41897; Evidence=; Reaction=(2E)-hexadecenoyl-[ACP] + H(+) + NADPH = hexadecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41912, Rhea:RHEA-COMP:9651, Rhea:RHEA- COMP:9652, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78481, ChEBI:CHEBI:78483; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41913; Evidence=; Homodimer. Mitochondrion Expressed in Purkinje cells (at protein level). Homozygous deficiency causes placental insufficiency and embryonic lethality between 9.5 and 11.5 dpc. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. receptor binding nucleus mitochondrion cytosol lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process oxidoreductase activity ligand-dependent nuclear receptor binding trans-2-enoyl-CoA reductase (NADPH) activity oxidation-reduction process uc008vae.1 uc008vae.2 uc008vae.3 uc008vae.4 
ENSMUST00000030747.11 Casp9 ENSMUST00000030747.11 caspase 9, transcript variant 1 (from RefSeq NM_015733.5) CASP9_MOUSE ENSMUST00000030747.1 ENSMUST00000030747.10 ENSMUST00000030747.2 ENSMUST00000030747.3 ENSMUST00000030747.4 ENSMUST00000030747.5 ENSMUST00000030747.6 ENSMUST00000030747.7 ENSMUST00000030747.8 ENSMUST00000030747.9 Mch6 NM_015733 Q8C3Q9 uc008vpi.1 uc008vpi.2 uc008vpi.3 uc008vpi.4 This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, the initiator caspase, is activated after cytochrome c release from mitochondria and targets downstream effectors. In mouse, deficiency of this gene can cause perinatal lethality. This protein may have a role in normal brain development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]. Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage- induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Reaction=Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-|-Xaa.; EC=3.4.22.62; Evidence=; Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts (inactive form) with EFHD2. Interacts with HAX1. Interacts with BIRC2/c-IAP1, XIAP/BIRC4, BIRC5/survivin, BIRC6/bruce and BIRC7/livin. Interacts with ABL1 (via SH3 domain); the interaction is direct and increased in the response of cells to genotoxic stress and ABL1/c-Abl activation (By similarity). Interacts with BCL2L10 (By similarity). Cleavages at Asp-353 by granzyme B and at Asp-368 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events (By similarity). Phosphorylated at Thr-163 by MAPK1/ERK2. Phosphorylation at Thr- 163 is sufficient to block caspase-9 processing and subsequent caspase- 3 activation (By similarity). Phosphorylation on Tyr-191 by ABL1/c-Abl; occurs in the response of cells to DNA damage (PubMed:15657060). Belongs to the peptidase C14A family. kidney development response to ischemia cysteine-type endopeptidase activity protein binding nucleus cytoplasm mitochondrion cytosol proteolysis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus aging peptidase activity cysteine-type peptidase activity intrinsic apoptotic signaling pathway in response to DNA damage response to UV response to organic cyclic compound hydrolase activity SH3 domain binding protein kinase binding response to cobalt ion response to estradiol response to lipopolysaccharide macromolecular complex glial cell apoptotic process cellular response to UV signal transduction in response to DNA damage identical protein binding regulation of apoptotic process positive regulation of apoptotic process apoptosome positive regulation of neuron apoptotic process response to antibiotic intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to organic cyclic compound cellular response to dexamethasone stimulus leukocyte apoptotic process cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity involved in apoptotic signaling pathway regulation of response to DNA damage stimulus uc008vpi.1 uc008vpi.2 uc008vpi.3 uc008vpi.4 
ENSMUST00000030757.10 Fbxo42 ENSMUST00000030757.10 F-box protein 42 (from RefSeq NM_172518.3) A2A824 ENSMUST00000030757.1 ENSMUST00000030757.2 ENSMUST00000030757.3 ENSMUST00000030757.4 ENSMUST00000030757.5 ENSMUST00000030757.6 ENSMUST00000030757.7 ENSMUST00000030757.8 ENSMUST00000030757.9 FBX42_MOUSE NM_172518 Q6PDJ6 Q8CE76 Q99KY2 uc008vnz.1 uc008vnz.2 uc008vnz.3 uc008vnz.4 Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation (By similarity). Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction is direct (By similarity). molecular_function cellular_component biological_process uc008vnz.1 uc008vnz.2 uc008vnz.3 uc008vnz.4 
ENSMUST00000030760.15 Necap2 ENSMUST00000030760.15 NECAP endocytosis associated 2, transcript variant 2 (from RefSeq NR_149724.1) ENSMUST00000030760.1 ENSMUST00000030760.10 ENSMUST00000030760.11 ENSMUST00000030760.12 ENSMUST00000030760.13 ENSMUST00000030760.14 ENSMUST00000030760.2 ENSMUST00000030760.3 ENSMUST00000030760.4 ENSMUST00000030760.5 ENSMUST00000030760.6 ENSMUST00000030760.7 ENSMUST00000030760.8 ENSMUST00000030760.9 NECP2_MOUSE NR_149724 Q3U1M1 Q9CV41 Q9D1J1 uc008vnu.1 uc008vnu.2 uc008vnu.3 uc008vnu.4 Involved in endocytosis. Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with the GAE domain proteins GGA1, GGA2 and GGA3. Cytoplasmic vesicle, clathrin-coated vesicle membrane Cell membrane Note=Colocalizes with AP-2 at the plasma membrane. Expressed in brain, heart, kidney, liver, lung, skeletal muscles and testis (at protein level). The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity). Belongs to the NECAP family. molecular_function plasma membrane endocytosis biological_process protein transport membrane clathrin vesicle coat clathrin-coated vesicle membrane cytoplasmic vesicle uc008vnu.1 uc008vnu.2 uc008vnu.3 uc008vnu.4 
ENSMUST00000030763.13 Cdk14 ENSMUST00000030763.13 cyclin dependent kinase 14, transcript variant 1 (from RefSeq NM_011074.4) CDK14_MOUSE ENSMUST00000030763.1 ENSMUST00000030763.10 ENSMUST00000030763.11 ENSMUST00000030763.12 ENSMUST00000030763.2 ENSMUST00000030763.3 ENSMUST00000030763.4 ENSMUST00000030763.5 ENSMUST00000030763.6 ENSMUST00000030763.7 ENSMUST00000030763.8 ENSMUST00000030763.9 Kiaa0834 NM_011074 O35495 O35848 Pftk1 Q3TNN9 Q3V319 Q6ZQ37 uc008wii.1 uc008wii.2 uc008wii.3 uc008wii.4 uc008wii.5 Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A. Found in a complex with LRP6, CCNY and CAPRIN2 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus. Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ. Cell membrane ; Peripheral membrane protein Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O35495-1; Sequence=Displayed; Name=2; IsoId=O35495-2; Sequence=VSP_038763; Name=3; IsoId=O35495-3; Sequence=VSP_038764; In the adult, widely expressed at low levels except in brain, kidney and testis where expression is high. In the brain, detected in cortex, hippocampus, dentate gyrus, amygdala cortex, parasubiculum and cerebellum. In the embryo, expressed predominantly in the nervous system. In the testis, expressed at low levels in Sertoli cells of 7-day-old mice, barely detected at day 17, and detected at much higher levels in late pachytene/diplotene spermatocytes in the adult. In the nervous system, expressed at highest levels in the adult. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. G2/M transition of mitotic cell cycle nucleotide binding cytoplasmic cyclin-dependent protein kinase holoenzyme complex protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus cytoplasm cytosol plasma membrane protein phosphorylation cell cycle membrane Wnt signaling pathway kinase activity phosphorylation transferase activity cyclin binding cell division regulation of cell cycle regulation of canonical Wnt signaling pathway uc008wii.1 uc008wii.2 uc008wii.3 uc008wii.4 uc008wii.5 
ENSMUST00000030765.7 Padi2 ENSMUST00000030765.7 peptidyl arginine deiminase, type II, transcript variant 1 (from RefSeq NM_008812.3) ENSMUST00000030765.1 ENSMUST00000030765.2 ENSMUST00000030765.3 ENSMUST00000030765.4 ENSMUST00000030765.5 ENSMUST00000030765.6 NM_008812 PADI2_MOUSE Pad2 Pdi Pdi2 Q08642 Q75WD0 uc008vni.1 uc008vni.2 uc008vni.3 uc008vni.4 Catalyzes the deimination of arginine residues of proteins. Reaction=H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+); Xref=Rhea:RHEA:18089, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:10588, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29965, ChEBI:CHEBI:83397; EC=3.5.3.15; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binding of Ca(2+) triggers a conformation change that is essential for catalytic activity. ; Homodimer. Cytoplasm Expressed in various tissues including muscle, uterus, spinal cord, salivary gland and pancreas. Expressed during the estrus cycle. Expressed during diestrus and proestrus with an eight fold decline when estrus cycle is reached. Belongs to the protein arginine deiminase family. protein-arginine deiminase activity calcium ion binding nucleus cytoplasm regulation of chromatin disassembly hydrolase activity protein citrullination estrogen receptor binding intracellular estrogen receptor signaling pathway transcriptionally active chromatin histone H3-R26 citrullination histone citrullination protein homodimerization activity metal ion binding chromatin-mediated maintenance of transcription negative regulation of chemokine-mediated signaling pathway negative regulation of lymphocyte chemotaxis cellular response to leukemia inhibitory factor uc008vni.1 uc008vni.2 uc008vni.3 uc008vni.4 
ENSMUST00000030769.7 Psmc2 ENSMUST00000030769.7 proteasome (prosome, macropain) 26S subunit, ATPase 2, transcript variant 2 (from RefSeq NM_011188.4) ENSMUST00000030769.1 ENSMUST00000030769.2 ENSMUST00000030769.3 ENSMUST00000030769.4 ENSMUST00000030769.5 ENSMUST00000030769.6 NM_011188 Psmc2 Q8BVQ9 Q8BVQ9_MOUSE uc008wpd.1 uc008wpd.2 uc008wpd.3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Belongs to the AAA ATPase family. nucleotide binding proteasome complex ATP binding cytoplasm cytosol ubiquitin-dependent protein catabolic process hydrolase activity ATPase activity protein catabolic process proteasome-activating ATPase activity cytoplasmic ribonucleoprotein granule positive regulation of proteasomal protein catabolic process uc008wpd.1 uc008wpd.2 uc008wpd.3 
ENSMUST00000030771.12 Dnajc2 ENSMUST00000030771.12 DnaJ heat shock protein family (Hsp40) member C2, transcript variant 1 (from RefSeq NM_009584.5) DNJC2_MOUSE ENSMUST00000030771.1 ENSMUST00000030771.10 ENSMUST00000030771.11 ENSMUST00000030771.2 ENSMUST00000030771.3 ENSMUST00000030771.4 ENSMUST00000030771.5 ENSMUST00000030771.6 ENSMUST00000030771.7 ENSMUST00000030771.8 ENSMUST00000030771.9 Mida1 NM_009584 P54103 Q61866 Zrf1 uc008wpa.1 uc008wpa.2 uc008wpa.3 Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2 (By similarity). Interacts (via ZRF1-UBD region) with ID1 (PubMed:10581180, PubMed:7559602). Nucleus toplasm, cytosol Expressed in all tissues. The ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby preventing its association with H2AK119ub. Phosphorylated in M (mitotic) phase. DNA binding chromatin binding protein binding nucleus cytoplasm cytosol DNA replication chromatin organization negative regulation of cell growth Hsp70 protein binding nuclear membrane histone binding positive regulation of transcription, DNA-templated ubiquitinated histone binding negative regulation of DNA biosynthetic process uc008wpa.1 uc008wpa.2 uc008wpa.3 
ENSMUST00000030773.12 Xrcc2 ENSMUST00000030773.12 X-ray repair complementing defective repair in Chinese hamster cells 2 (from RefSeq NM_020570.2) ENSMUST00000030773.1 ENSMUST00000030773.10 ENSMUST00000030773.11 ENSMUST00000030773.2 ENSMUST00000030773.3 ENSMUST00000030773.4 ENSMUST00000030773.5 ENSMUST00000030773.6 ENSMUST00000030773.7 ENSMUST00000030773.8 ENSMUST00000030773.9 NM_020570 O88730 Q9CX47 Q9D5T1 XRCC2_MOUSE uc008wta.1 uc008wta.2 uc008wta.3 uc008wta.4 Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA (By similarity). Interacts with RAD51D. Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disk around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA (By similarity). Nucleus Expressed at low level in somatic tissues and at high level in testis. Belongs to the RecA family. RAD51 subfamily. mitotic cell cycle four-way junction DNA binding double-strand break repair via homologous recombination in utero embryonic development somitogenesis DNA binding protein binding ATP binding nucleus nucleoplasm replication fork centrosome DNA repair DNA recombination cellular response to DNA damage stimulus centrosome cycle DNA-dependent ATPase activity response to X-ray response to gamma radiation neurogenesis Rad51B-Rad51C-Rad51D-XRCC2 complex multicellular organism growth strand invasion intracellular membrane-bounded organelle negative regulation of neuron apoptotic process positive regulation of neurogenesis regulation of fibroblast apoptotic process uc008wta.1 uc008wta.2 uc008wta.3 uc008wta.4 
ENSMUST00000030775.12 Chd5 ENSMUST00000030775.12 chromodomain helicase DNA binding protein 5, transcript variant 1 (from RefSeq NM_001081376.1) Chd5 E9PYL1 E9PYL1_MOUSE ENSMUST00000030775.1 ENSMUST00000030775.10 ENSMUST00000030775.11 ENSMUST00000030775.2 ENSMUST00000030775.3 ENSMUST00000030775.4 ENSMUST00000030775.5 ENSMUST00000030775.6 ENSMUST00000030775.7 ENSMUST00000030775.8 ENSMUST00000030775.9 NM_001081376 uc008wai.1 uc008wai.2 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Belongs to the SNF2/RAD54 helicase family. ATP binding nucleus nucleoplasm cytosol nuclear speck metal ion binding regulation of transcription involved in cell fate commitment H3K27me3 modified histone binding histone H3-K27 trimethylation uc008wai.1 uc008wai.2 
ENSMUST00000030782.2 Hes2 ENSMUST00000030782.2 hes family bHLH transcription factor 2, transcript variant 2 (from RefSeq NM_008236.4) ENSMUST00000030782.1 HES2_MOUSE NM_008236 O54792 Q8BKA6 uc008vzw.1 uc008vzw.2 The protein encoded by this gene belongs to the mammalian Hes gene family, the mammalian homologues of Drosophila hairy and Enhancer of split. Hes 2 is a basic helix-loop-helix transcriptional repressor and is an effector of the Notch signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. Transcriptional repressor of genes that require a bHLH protein for their transcription. Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Nucleus. Has a particular type of basic domain (presence of a helix- interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG). The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy- related proteins. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding nucleus regulation of transcription, DNA-templated transcription factor binding anterior/posterior pattern specification cell differentiation negative regulation of transcription, DNA-templated protein dimerization activity regulation of neurogenesis uc008vzw.1 uc008vzw.2 
ENSMUST00000030784.14 Prkag2 ENSMUST00000030784.14 protein kinase, AMP-activated, gamma 2 non-catalytic subunit, transcript variant 1 (from RefSeq NM_145401.2) AAKG2_MOUSE E9QK80 ENSMUST00000030784.1 ENSMUST00000030784.10 ENSMUST00000030784.11 ENSMUST00000030784.12 ENSMUST00000030784.13 ENSMUST00000030784.2 ENSMUST00000030784.3 ENSMUST00000030784.4 ENSMUST00000030784.5 ENSMUST00000030784.6 ENSMUST00000030784.7 ENSMUST00000030784.8 ENSMUST00000030784.9 NM_145401 Q6V7V5 Q91WG5 uc008wsm.1 uc008wsm.2 uc008wsm.3 uc008wsm.4 AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=Q91WG5-1; Sequence=Displayed; Name=B; IsoId=Q91WG5-2; Sequence=VSP_015586; The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK, except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstrate sequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by the upstream activating kinase STK11/LKB1 (By similarity). The 4 CBS domains mediate binding to nucleotides. Of the 4 potential nucleotide-binding sites, 3 are occupied, designated as sites 1, 3, and 4 based on the CBS modules that provide the acidic residue for coordination with the 2'- and 3'-hydroxyl groups of the ribose of AMP. Of these, site 4 appears to be a structural site that retains a tightly held AMP molecule (AMP 3). The 2 remaining sites, 1 and 3, can bind either AMP, ADP or ATP. Site 1 (AMP, ADP or ATP 1) is the high- affinity binding site and likely accommodates AMP or ADP. Site 3 (AMP, ADP or ATP 2) is the weakest nucleotide-binding site on the gamma subunit, yet it is exquisitely sensitive to changes in nucleotide levels and this allows AMPK to respond rapidly to changes in cellular energy status. Site 3 is likely to be responsible for protection of a conserved threonine in the activation loop of the alpha catalytic subunit through conformational changes induced by binding of AMP or ADP. Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. Glycosylated; O-GlcNAcylated by OGT, promoting the AMP-activated protein kinase (AMPK) activity. Belongs to the 5'-AMP-activated protein kinase gamma subunit family. nucleotide binding AMP-activated protein kinase activity cAMP-dependent protein kinase inhibitor activity ATP binding nucleoplasm cytosol glycogen metabolic process regulation of glycolytic process protein phosphorylation negative regulation of protein kinase activity lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process cAMP-dependent protein kinase regulator activity phosphorylase kinase regulator activity positive regulation of peptidyl-threonine phosphorylation AMP binding regulation of fatty acid metabolic process protein kinase binding protein kinase activator activity nucleotide-activated protein kinase complex activation of protein kinase activity adenyl ribonucleotide binding intracellular signal transduction ADP binding positive regulation of protein kinase activity regulation of catalytic activity regulation of protein serine/threonine kinase activity negative regulation of protein serine/threonine kinase activity uc008wsm.1 uc008wsm.2 uc008wsm.3 uc008wsm.4 
ENSMUST00000030785.15 Espn ENSMUST00000030785.15 espin, transcript variant 1 (from RefSeq NM_207687.3) A2AK06 A2AK09 A2AK13 B1AWP3 B1AWP6 B1AWQ2 ENSMUST00000030785.1 ENSMUST00000030785.10 ENSMUST00000030785.11 ENSMUST00000030785.12 ENSMUST00000030785.13 ENSMUST00000030785.14 ENSMUST00000030785.2 ENSMUST00000030785.3 ENSMUST00000030785.4 ENSMUST00000030785.5 ENSMUST00000030785.6 ENSMUST00000030785.7 ENSMUST00000030785.8 ENSMUST00000030785.9 ESPN_MOUSE NM_207687 Q6GYS0 Q6GYS1 Q80ZC0 Q80ZC1 Q80ZC2 Q80ZC3 Q9ET47 Q9QY27 uc008vzt.1 uc008vzt.2 uc008vzt.3 Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:14657236, PubMed:15190118). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (PubMed:21455486). Involved in the elongation of actin in stereocilia (PubMed:19287378, PubMed:22264607). In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation (PubMed:26926603). Monomer (Probable). Binds F-actin in a Ca(2+)-resistant fashion (PubMed:10588661). Interacts (via N-terminus) with BAIAP2 (via SH3-domain) (PubMed:12598619). Interacts with PFN2 (PubMed:15190118). Interacts with MYO3A (via C-terminus) (PubMed:26926603). Interacts with MYO3B (via C-terminus) (PubMed:26926603, PubMed:26785147). Cytoplasm, cytoskeleton. Cell projection, stereocilium Cell projection, microvillus. Cell junction. [Isoform 2]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine. [Isoform 3]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine. [Isoform 4]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine. [Isoform 5]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine. [Isoform 8]: Cytoplasm, cytoskeleton. Cell junction. Note=Isoform 8 localizes to parallel actin bundles of ectoplasmic specializations between neighboring Sertoli cells and at sites where Sertoli cells contact the heads of elongate spermatids. Event=Alternative splicing; Named isoforms=8; Name=1; IsoId=Q9ET47-1; Sequence=Displayed; Name=2; Synonyms=Purkinje cell espin isoform 1; IsoId=Q9ET47-2; Sequence=VSP_033733, VSP_033734, VSP_033736, VSP_033739; Name=3; Synonyms=Purkinje cell espin isoform 1+; IsoId=Q9ET47-3; Sequence=VSP_033733, VSP_033734, VSP_033736; Name=4; Synonyms=Purkinje cell espin isoform 2+; IsoId=Q9ET47-4; Sequence=VSP_033733, VSP_033734, VSP_033735; Name=5; Synonyms=Purkinje cell espin isoform 2; IsoId=Q9ET47-5; Sequence=VSP_033733, VSP_033734, VSP_033735, VSP_033739; Name=6; Synonyms=3B; IsoId=Q9ET47-6; Sequence=VSP_033732, VSP_033737, VSP_033739; Name=7; Synonyms=3A; IsoId=Q9ET47-7; Sequence=VSP_033731, VSP_033739; Name=8; Synonyms=small; IsoId=Q9ET47-8; Sequence=VSP_033730, VSP_033738, VSP_033740; Expressed at high concentration in the microvillar parallel actin bundle (PAB) of hair cells stereocilia in the cochlea and vestibular system. Detected also at high levels of a number of other sensory cell types, including taste receptor cells, solitary chemoreceptor cells, vomeronasal sensory neurons and Merkel cells. Isoforms 2, 3, 4 and 5 are expressed in Purkinje cells dendritic spines. Expressed in utricle hair bundles (at protein level) (PubMed:26926603). The WH2-domain binds actin monomer and mediates actin bundle assembly. Jerker mice have a frameshift mutation that affect the espin C-terminus. This mutation cause deafness, vestibular dysfunction and hair cell degeneration. actin binding protein binding cytoplasm cytoskeleton microvillus brush border sensory perception of sound locomotory behavior actin cytoskeleton SH3 domain binding parallel actin filament bundle assembly cell junction filamentous actin stereocilium stereocilium bundle stereocilium tip cell projection dendritic spine actin filament binding actin filament bundle assembly positive regulation of filopodium assembly negative regulation of cytoskeleton organization actin filament network formation uc008vzt.1 uc008vzt.2 uc008vzt.3 
ENSMUST00000030787.9 Rheb ENSMUST00000030787.9 Ras homolog enriched in brain (from RefSeq NM_053075.3) ENSMUST00000030787.1 ENSMUST00000030787.2 ENSMUST00000030787.3 ENSMUST00000030787.4 ENSMUST00000030787.5 ENSMUST00000030787.6 ENSMUST00000030787.7 ENSMUST00000030787.8 NM_053075 Q921J2 RHEB_MOUSE Rheb uc008wsj.1 uc008wsj.2 uc008wsj.3 Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12820960, PubMed:16631613, PubMed:21321084, PubMed:24648513). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (By similarity). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (By similarity). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (By similarity). Has low intrinsic GTPase activity (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Alternates between an inactive form bound to GDP and an active form bound to GTP (PubMed:24648513). Inactivated by the TSC-TBC complex via the GTPase activating protein (GAP) domain of TSC2 (PubMed:12820960). Autoinhibited by Tyr-35, which constrains the active site conformation, restricting the access of the catalytic Asp-65 to the nucleotide-binding pocket (By similarity). Associates with the mTORC1 complex (MTOR, MLST8 and RPTOR) in a guanyl nucleotide-independent manner (By similarity). Interacts with TSC2 (By similarity). Interacts (when prenylated) with PDE6D; this promotes release from membranes (By similarity). Endomembrane system ; Lipid-anchor ; Cytoplasmic side Lysosome membrane ; Lipid-anchor ; Cytoplasmic side Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side Endoplasmic reticulum membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasm, cytosol Note=Farnesylation is required for localization to endomembrane system. Farnesylation is important for efficiently activating mTORC1- mediated signaling. Polyubiquitinated in response to amino acid, promoting its interaction with MTOR and mTORC1 activation. Deubiquitination by ATXN3 promotes recruitment of the TSC-TBC complex and RHEB inactivation by TSC2. Monoubiquitinated at Lys-8 by RNF152, promoting its association with the TSC-TBC complex. Deubiquitinated at Lys-8 by USP4, promoting mTORC1 activation. Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation. Embryonic lethality around midgestation (PubMed:21321084). The inner cell mass differentiates normally, but embryos do not develop beyond 12 dpc embryos, due to impaired development of the cardiovascular system (PubMed:21321084). The conserved catalytic Gln-64 found in other Ras-like GTPases seems not to be involved in GTP hydrolysis in RHEB. Belongs to the small GTPase superfamily. Rheb family. Golgi membrane nucleotide binding magnesium ion binding GTPase activity GTP binding spliceosomal complex cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol plasma membrane signal transduction small GTPase mediated signal transduction endomembrane system postsynaptic density membrane GDP binding protein kinase binding dendrite regulation of TOR signaling positive regulation of TOR signaling neuronal cell body metal ion binding positive regulation of oligodendrocyte differentiation glutamatergic synapse regulation of type B pancreatic cell development uc008wsj.1 uc008wsj.2 uc008wsj.3 
ENSMUST00000030791.12 Smarcd3 ENSMUST00000030791.12 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 (from RefSeq NM_025891.3) Baf60c ENSMUST00000030791.1 ENSMUST00000030791.10 ENSMUST00000030791.11 ENSMUST00000030791.2 ENSMUST00000030791.3 ENSMUST00000030791.4 ENSMUST00000030791.5 ENSMUST00000030791.6 ENSMUST00000030791.7 ENSMUST00000030791.8 ENSMUST00000030791.9 NM_025891 Q6P9Z1 Q921D3 Q9CX89 Q9DB99 SMRD3_MOUSE uc008wsd.1 uc008wsd.2 uc008wsd.3 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:22952240, PubMed:26601204). Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (Probable). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3 (By similarity). Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity). May be a component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (PubMed:22952240, PubMed:26601204). Component of SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). Interacts with SMARCA4/BRG1/BAF190A. The precise distribution of the related SMARCD1, SMARCD2 and SMARCD3 proteins among these and other SWI/SNF nucleosome-remodeling complexes is not fully known. May allow recruitment of SWI/SNF containing complexes specifically to promoters where these factors are located. Also interacts with several nuclear receptors including PPARG/NR1C3, RXRA/NR1F1, ESR1, NR5A1, NR5A2/LRH1 and other transcriptional activators including the HLH protein SREBF1/SREBP1 and the homeobox protein PBX1 (By similarity). Interacts with PRDM1/BLIMP1 (By similarity). Q6P9Z1; P10085: Myod1; NbExp=6; IntAct=EBI-7525857, EBI-4405734; Q6P9Z1; Q01705: Notch1; NbExp=2; IntAct=EBI-7525857, EBI-1392707; Q6P9Z1; P31266: Rbpj; NbExp=3; IntAct=EBI-7525857, EBI-1392666; Q6P9Z1; Q3TKT4: Smarca4; NbExp=3; IntAct=EBI-7525857, EBI-1210244; Nucleus Ubiquitously expressed. Belongs to the SMARCD family. Sequence=BAB23813.1; Type=Frameshift; Evidence=; nuclear chromatin positive regulation of neuroblast proliferation heart morphogenesis secondary heart field specification cardiac right ventricle formation neural retina development chromatin binding receptor binding protein binding nucleus nucleoplasm cytoplasm chromatin organization nucleosome disassembly chromatin remodeling transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nervous system development transcription factor binding positive regulation of G2/M transition of mitotic cell cycle SWI/SNF complex ligand-dependent nuclear receptor binding ligand-dependent nuclear receptor transcription coactivator activity nuclear hormone receptor binding muscle cell differentiation regulation of protein binding positive regulation of transcription, DNA-templated positive regulation of smooth muscle cell differentiation npBAF complex nBAF complex uc008wsd.1 uc008wsd.2 uc008wsd.3 
ENSMUST00000030792.2 Tas1r1 ENSMUST00000030792.2 taste receptor, type 1, member 1 (from RefSeq NM_031867.2) ENSMUST00000030792.1 NM_031867 Q3U5H1 Q3U5H1_MOUSE Tas1r1 uc008vza.1 uc008vza.2 uc008vza.3 uc008vza.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway taste receptor activity membrane integral component of membrane detection of chemical stimulus involved in sensory perception of taste sensory perception of umami taste uc008vza.1 uc008vza.2 uc008vza.3 uc008vza.4 
ENSMUST00000030795.10 Abcf2 ENSMUST00000030795.10 ATP-binding cassette, sub-family F member 2, transcript variant 1 (from RefSeq NM_013853.2) ABCF2_MOUSE Abcf2 ENSMUST00000030795.1 ENSMUST00000030795.2 ENSMUST00000030795.3 ENSMUST00000030795.4 ENSMUST00000030795.5 ENSMUST00000030795.6 ENSMUST00000030795.7 ENSMUST00000030795.8 ENSMUST00000030795.9 NM_013853 Q3UA24 Q8C1S5 Q99LE6 Q9JL48 uc008wsb.1 uc008wsb.2 uc008wsb.3 uc008wsb.4 Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. Lacks transmembrane domains and is probably not involved in transport. nucleotide binding ATP binding mitochondrion biological_process ATPase activity uc008wsb.1 uc008wsb.2 uc008wsb.3 uc008wsb.4 
ENSMUST00000030797.4 Vamp3 ENSMUST00000030797.4 vesicle-associated membrane protein 3 (from RefSeq NM_009498.4) ENSMUST00000030797.1 ENSMUST00000030797.2 ENSMUST00000030797.3 NM_009498 P63024 Q3TH70 Q64271 Syb3 VAMP3_MOUSE uc008vyj.1 uc008vyj.2 uc008vyj.3 SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum. Interacts with BAIAP3; this interaction is increased in the presence of calcium (By similarity). Interacts with PICALM (By similarity). Early endosome membrane ; Single-pass type IV membrane protein Recycling endosome membrane ; Single-pass type I membrane protein Synapse, synaptosome Ubiquitinated by RNF167 at Lys-70, Lys-72 and Lys-81, regulating the recycling endosome pathway. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 53-Arg-|-Ala-54 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets. Belongs to the synaptobrevin family. SNARE binding positive regulation of receptor recycling protein binding cytosol plasma membrane cell surface protein transport membrane integral component of membrane vesicle-mediated transport apical plasma membrane syntaxin-1 binding calcium ion regulated exocytosis cell junction clathrin-coated vesicle secretory granule integral component of synaptic vesicle membrane clathrin-coated vesicle membrane SNARE complex cytoplasmic vesicle substrate adhesion-dependent cell spreading SNARE complex assembly retrograde transport, endosome to Golgi Golgi to plasma membrane protein transport neuron projection intracellular organelle intracellular membrane-bounded organelle synapse phagocytic vesicle perinuclear region of cytoplasm recycling endosome macromolecular complex assembly cellular response to interferon-gamma negative regulation of secretion by cell uc008vyj.1 uc008vyj.2 uc008vyj.3 
ENSMUST00000030799.15 Tmub1 ENSMUST00000030799.15 transmembrane and ubiquitin-like domain containing 1 (from RefSeq NM_022418.3) ENSMUST00000030799.1 ENSMUST00000030799.10 ENSMUST00000030799.11 ENSMUST00000030799.12 ENSMUST00000030799.13 ENSMUST00000030799.14 ENSMUST00000030799.2 ENSMUST00000030799.3 ENSMUST00000030799.4 ENSMUST00000030799.5 ENSMUST00000030799.6 ENSMUST00000030799.7 ENSMUST00000030799.8 ENSMUST00000030799.9 Hops NM_022418 Q53AQ3 Q9JMG3 TMUB1_MOUSE uc008wrt.1 uc008wrt.2 uc008wrt.3 uc008wrt.4 Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (By similarity). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as a negative regulator of hepatocyte growth during regeneration (By similarity). [iHOPS]: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (PubMed:16014383). May be involved in centrosome assembly (PubMed:18418082). Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (PubMed:22890319). Interacts with EEF1A1, CAMLG, GRIA2 and GRIP1. Interacts with NPM1 and CDKN2A; TMUB1 can enhance interaction between NPM1 and CDKN2A and is proposed to bridge the proteins; proposed to be mediated by iHOPS (PubMed:16014383, PubMed:18665261, PubMed:20582322, PubMed:22890319, PubMed:24240191). Interacts with TUBG1 (By similarity). Interacts with ERLIN2 and AMFR; TMUB1 promotes the interaction of ERLIN2 with AMFR (By similarity). Membrane ; Multi- pass membrane protein Postsynaptic cell membrane Recycling endosome Cytoplasm cleus Nucleus, nucleolus [Isoform 1]: Membrane [Isoform 2]: Membrane [iHOPS]: Cytoplasm toplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus, nucleolus Nucleus Note=iHOPS is proposed to be the shuttling form across different cellular compartments (PubMed:24240191). XPO1-dependent exported from the nucleus in dividing cells. Predominantly nuclear during growth arrest (PubMed:16014383). Event=Alternative initiation; Named isoforms=2; Name=1; Synonyms=lHOPS; IsoId=Q9JMG3-1; Sequence=Displayed; Name=2; Synonyms=sHOPS; IsoId=Q9JMG3-2; Sequence=VSP_058102; Expressed in adult brain; at protein level (PubMed:18665261, PubMed:20582322). Isoform 1 (lHOPS) is highly expressed in small intestine, stomach and epididymis. Isoform 2 (sHOPS) and iHOPS are abundantly expressed in brain, liver and adrenal gland (PubMed:24240191). Up-regulated in regenerating liver. [iHOPS]: Isoform 1 (lHOPS) is processed by regulated intramembrane proteolysis (RIP) in the N-terminus to release iHOPS from membranes. Isoform 2 seems to undergo a selective cleavage in the C-terminal region to release an additional cytoplasmic form. Strong increase in home cage locomotor activity during the dark phase (subjective day) of the light:dark (L:D) cycle. There were no changes in activity during the light period and in locomotor activity observed in other assays, e.g. novel open-field. nucleus nucleoplasm nucleolus cytoplasm endosome microtubule organizing center cytosol cytoskeleton plasma membrane membrane integral component of membrane cell junction ER-associated ubiquitin-dependent protein catabolic process synapse postsynaptic membrane recycling endosome uc008wrt.1 uc008wrt.2 uc008wrt.3 uc008wrt.4 
ENSMUST00000030800.13 Fastk ENSMUST00000030800.13 Fas-activated serine/threonine kinase (from RefSeq NM_023229.2) ENSMUST00000030800.1 ENSMUST00000030800.10 ENSMUST00000030800.11 ENSMUST00000030800.12 ENSMUST00000030800.2 ENSMUST00000030800.3 ENSMUST00000030800.4 ENSMUST00000030800.5 ENSMUST00000030800.6 ENSMUST00000030800.7 ENSMUST00000030800.8 ENSMUST00000030800.9 Fastk NM_023229 Q8C725 Q8C725_MOUSE uc008wrq.1 uc008wrq.2 uc008wrq.3 protein kinase activity protein serine/threonine kinase activity protein phosphorylation regulation of RNA splicing uc008wrq.1 uc008wrq.2 uc008wrq.3 
ENSMUST00000030803.2 Uts2 ENSMUST00000030803.2 urotensin 2 (from RefSeq NM_011910.2) ENSMUST00000030803.1 NM_011910 Q9QZQ3 UTS2_MOUSE Ucn2 uc008vyd.1 uc008vyd.2 This gene encodes a member of the urotensin family of peptide hormones. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone before secretion into the plasma. Mice lacking the encoded protein have a significantly decreased low density lipoprotein cholesterol profile and hepatic steatosis that is consistent with decreased hepatocyte de novo cholesterol synthesis and apolipoprotein B secretion. [provided by RefSeq, Sep 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF172175.1, BC107299.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164136, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Highly potent vasoconstrictor. Secreted. Brain specific. Predominantly expressed in motoneurons of the brainstem and spinal cord. Belongs to the urotensin-2 family. response to hypoxia negative regulation of glomerular filtration hormone activity extracellular region extracellular space cell signal transduction positive regulation of cytosolic calcium ion concentration regulation of blood pressure negative regulation of heart rate positive regulation of heart rate positive regulation of fibroblast migration positive regulation of circadian sleep/wake cycle, wakefulness positive regulation of synaptic transmission, cholinergic positive regulation of collagen biosynthetic process response to testosterone negative regulation of urine volume negative regulation of renal sodium excretion response to drug positive regulation of cell differentiation positive regulation of angiogenesis negative regulation of blood pressure positive regulation of blood pressure positive regulation of circadian sleep/wake cycle, REM sleep negative regulation of insulin secretion positive regulation of fibroblast proliferation regulation of blood vessel diameter uc008vyd.1 uc008vyd.2 
ENSMUST00000030808.10 Tnfrsf9 ENSMUST00000030808.10 tumor necrosis factor receptor superfamily, member 9, transcript variant 1 (from RefSeq NM_011612.2) ENSMUST00000030808.1 ENSMUST00000030808.2 ENSMUST00000030808.3 ENSMUST00000030808.4 ENSMUST00000030808.5 ENSMUST00000030808.6 ENSMUST00000030808.7 ENSMUST00000030808.8 ENSMUST00000030808.9 NM_011612 Q3U3R1 Q3U3R1_MOUSE Tnfrsf9 uc008vya.1 uc008vya.2 uc008vya.3 apoptotic process negative regulation of cell proliferation external side of plasma membrane membrane integral component of membrane signaling receptor activity uc008vya.1 uc008vya.2 uc008vya.3 
ENSMUST00000030813.10 Cenps ENSMUST00000030813.10 centromere protein S (from RefSeq NM_027263.2) A2AH77 Apitd1 CENPS_MOUSE ENSMUST00000030813.1 ENSMUST00000030813.2 ENSMUST00000030813.3 ENSMUST00000030813.4 ENSMUST00000030813.5 ENSMUST00000030813.6 ENSMUST00000030813.7 ENSMUST00000030813.8 ENSMUST00000030813.9 FAAP16 MHF1 NM_027263 Q80ZS2 Q8BH28 Q9D084 uc008vvt.1 uc008vvt.2 uc008vvt.3 uc008vvt.4 DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own. Heterodimer with CENPX, sometimes called MHF; this interaction stabilizes both partners. MHF heterodimers can assemble to form tetrameric structures. MHF also coassemble with CENPT-CENPW heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex. Forms a discrete complex with FANCM and CENPX, called FANCM- MHF; this interaction, probably mediated by direct binding between CENPS and FANCM, leads to synergistic activation of double-stranded DNA binding and strongly stimulates FANCM-mediated DNA remodeling. Recruited by FANCM to the Fanconi anemia (FA) core complex, which consists of CENPS, CENPX, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FAAP24 and FAAP100. The FA core complex associates with Bloom syndrome (BLM) complex, which consists of at least BLM, DNA topoisomerase 3-alpha (TOP3A), RMI1/BLAP75, RPA1/RPA70 and RPA2/RPA32. The super complex between FA and BLM is called BRAFT. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Nucleus Chromosome, centromere Chromosome, centromere, kinetochore Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPS is more stably bound at the kinetochore than CENPX. During S phase, rapidly recruited to DNA interstrand cross-links that block replication. Recruited to DNA damage sites about 20 minutes following UV irradiation, reaching a plateau after approximately 40 minutes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D084-1; Sequence=Displayed; Name=2; IsoId=Q9D084-2; Sequence=VSP_020435, VSP_020436; Belongs to the TAF9 family. CENP-S/MHF1 subfamily. Sequence=BAC25385.1; Type=Frameshift; Evidence=; Sequence=BAC25387.1; Type=Frameshift; Evidence=; resolution of meiotic recombination intermediates chromosome, centromeric region kinetochore condensed chromosome kinetochore DNA binding chromatin binding double-stranded DNA binding nucleus chromosome DNA repair cellular response to DNA damage stimulus cell cycle replication fork processing Fanconi anaemia nuclear complex protein heterodimerization activity cell division kinetochore assembly FANCM-MHF complex uc008vvt.1 uc008vvt.2 uc008vvt.3 uc008vvt.4 
ENSMUST00000030814.11 Cdk5 ENSMUST00000030814.11 cyclin dependent kinase 5, transcript variant 2 (from RefSeq NR_156449.1) Cdk5 ENSMUST00000030814.1 ENSMUST00000030814.10 ENSMUST00000030814.2 ENSMUST00000030814.3 ENSMUST00000030814.4 ENSMUST00000030814.5 ENSMUST00000030814.6 ENSMUST00000030814.7 ENSMUST00000030814.8 ENSMUST00000030814.9 NR_156449 Q543F6 Q543F6_MOUSE uc008wrl.1 uc008wrl.2 uc008wrl.3 Postsynaptic density Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus cytoplasm cytosol cytoskeleton microtubule plasma membrane protein phosphorylation exocytosis nucleocytoplasmic transport mitochondrion organization skeletal muscle tissue development cytoskeletal protein binding response to wounding postsynaptic density membrane kinase activity phosphorylation cyclin-dependent protein kinase 5 holoenzyme complex histone phosphorylation peptidyl-serine phosphorylation protein kinase binding cell junction neuron differentiation axon dendrite growth cone cortical actin cytoskeleton organization neuron projection development neuromuscular junction positive regulation of glial cell apoptotic process neuron projection neuronal cell body positive regulation of neuron apoptotic process regulated exocytosis negative regulation of proteolysis negative regulation of transcription, DNA-templated protein autophosphorylation ephrin receptor binding regulation of synaptic plasticity synaptic vesicle endocytosis oligodendrocyte differentiation neuron projection morphogenesis tau-protein kinase activity neuron apoptotic process regulation of cell cycle presynapse postsynapse synapse disassembly glutamatergic synapse positive regulation of presynaptic cytosolic calcium concentration voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration negative regulation of neuron death positive regulation of neuron death positive regulation of voltage-gated calcium channel activity cellular response to beta-amyloid uc008wrl.1 uc008wrl.2 uc008wrl.3 
ENSMUST00000030815.3 Cort ENSMUST00000030815.3 cortistatin, transcript variant 1 (from RefSeq NM_007745.5) A2AH76 CORT_MOUSE ENSMUST00000030815.1 ENSMUST00000030815.2 NM_007745 P56469 Q9R1P8 uc008vvs.1 uc008vvs.2 uc008vvs.3 This gene encodes a member of the somatostatin family of multifunctional peptides attributed with neurohormone, neurotransmitter/modulator and autocrine/paracrine actions. The encoded preproprotein undergoes proteolytic processing to generate a mature functional peptide that can bind to somatostatin receptors. Mice lacking the encoded protein exhibit elevated levels of growth hormone in the plasma without major changes in somatic growth and have exacerbated nociceptive responses to neuropathic and inflammatory pain sensitization. Transgenic mice overexpressing the encoded protein in neurons do not express long-term potentiation in the dentate gyrus and exhibit deficits in synaptic plasticity and learning. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW490859.1, AK013496.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Secreted. Expressed in a subset of GABAergic cells in the cortex and hippocampus. Not induced by kainate. Belongs to the somatostatin family. G-protein coupled receptor binding hormone activity neuropeptide hormone activity extracellular region adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway neuropeptide signaling pathway regulation of circadian sleep/wake cycle, sleep Fanconi anaemia nuclear complex uc008vvs.1 uc008vvs.2 uc008vvs.3 
ENSMUST00000030816.4 Dffa ENSMUST00000030816.4 DNA fragmentation factor, alpha subunit, transcript variant 1 (from RefSeq NM_001025296.2) B2KFX0 DFFA_MOUSE ENSMUST00000030816.1 ENSMUST00000030816.2 ENSMUST00000030816.3 Icad NM_001025296 O54786 O54787 Q8BQC7 uc008vvr.1 uc008vvr.2 uc008vvr.3 uc008vvr.4 Inhibitor of the caspase-activated DNase (DFF40). Heterodimer of DFFA and DFFB. O54786; O54788: Dffb; NbExp=7; IntAct=EBI-1634519, EBI-7365197; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=ICAD-L; IsoId=O54786-1; Sequence=Displayed; Name=ICAD-S; IsoId=O54786-2; Sequence=VSP_001087, VSP_001088; Caspase-3 cleaves DFF45 at 2 sites to generate an active factor. nuclear chromatin protein binding nucleus cytoplasm cytosol plasma membrane apoptotic DNA fragmentation apoptotic process protein domain specific binding negative regulation of deoxyribonuclease activity positive regulation of apoptotic process protein binding involved in protein folding deoxyribonuclease inhibitor activity chaperone-mediated protein folding thymocyte apoptotic process negative regulation of execution phase of apoptosis negative regulation of apoptotic DNA fragmentation uc008vvr.1 uc008vvr.2 uc008vvr.3 uc008vvr.4 
ENSMUST00000030817.5 Car6 ENSMUST00000030817.5 carbonic anhydrase 6 (from RefSeq NM_009802.2) B1ARR5 CAH6_MOUSE Ca6 ENSMUST00000030817.1 ENSMUST00000030817.2 ENSMUST00000030817.3 ENSMUST00000030817.4 NM_009802 O88625 P18761 uc008vxn.1 uc008vxn.2 uc008vxn.3 uc008vxn.4 Reversible hydration of carbon dioxide. Its role in saliva is unknown. Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Secreted. Major constituent of saliva. Belongs to the alpha-carbonic anhydrase family. detection of chemical stimulus involved in sensory perception of bitter taste molecular_function carbonate dehydratase activity extracellular region extracellular space cytoplasm cytosol one-carbon metabolic process zinc ion binding lyase activity metal ion binding uc008vxn.1 uc008vxn.2 uc008vxn.3 uc008vxn.4 
ENSMUST00000030826.4 Slc2a5 ENSMUST00000030826.4 solute carrier family 2 (facilitated glucose transporter), member 5 (from RefSeq NM_019741.3) ENSMUST00000030826.1 ENSMUST00000030826.2 ENSMUST00000030826.3 GTR5_MOUSE Glut5 NM_019741 Q8R1N7 Q9WV38 Slc2a5 uc008vxk.1 uc008vxk.2 uc008vxk.3 Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:12031501, PubMed:19091748). Can mediate the uptake of deoxyglucose, but with low efficiency (By similarity). Essential for fructose uptake in the small intestine (PubMed:19091748, PubMed:26071406). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (PubMed:19091748). Required for the development of high blood pressure in response to high dietary fructose intake (PubMed:19091748). Reaction=D-fructose(out) = D-fructose(in); Xref=Rhea:RHEA:60372, ChEBI:CHEBI:37721; Evidence=; Fructose uptake is inhibited by cytochalasin B. Apical cell membrane ulti-pass membrane protein Cell membrane ; Multi-pass membrane protein Cell membrane, sarcolemma Note=Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi (PubMed:18496516, PubMed:26071406). Transport to the cell membrane is dependent on RAB11A (PubMed:26071406). Detected at the apical membrane of villi in the jejunum (PubMed:18496516, PubMed:19091748, PubMed:26071406). Detected in jejunum mucosa (PubMed:26071406). Detected in epididymis and whole testis (at protein level) (PubMed:18417103). Detected in small intestine, kidney and testis (PubMed:12031501, PubMed:18417103, PubMed:19091748). Detected in cochlea, but not in inner or outer cochlear hair cells (PubMed:18417103). Up-regulated in jejunum by dietary fructose intake (at protein level) (PubMed:18496516). Up-regulated in jejunum by dietary fructose intake (PubMed:18496516, PubMed:26071406). Up-regulated by dietary fructose intake in small intestine and testis (PubMed:12031501). Mice fed a standard diet appear normal and healthy, and display no visible phenotype (PubMed:18417103, PubMed:19091748, PubMed:26071406). Mutant mice show reduced food intake when kept on a high-frucose diet and about 28% reduction of their body weight within seven days. They loose more weight than wild-type mice that receive similar amounts of high-fructose food (PubMed:19091748). Mutant mice show strongly decreased fructose absorption in the jejunum (PubMed:19091748, PubMed:26071406). Contrary to wild-type, mutant mice have a strongly distended colon and caecum when kept on a high-fructose diet. Their intestines look normal when they are fed a standard diet. Contrary to wild-type, mutant mice do not display increased fructose levels in blood serum when kept on a high-fructose diet. Contrary to wild-type, they do not show increased salt absorption in response to fructose, and do not develop high blood pressure in response to fructose feeding. On the contrary, the blood pressure of mutant mice is strongly decreased after five days on a high-fructose diet. Mutant mice develop hypovolemic shock and die after 7 to 10 days on high-fructose diet (PubMed:19091748). Mutant mice display no defects of cochlear morphology or any hearing defects (PubMed:18417103). Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. regulation of systemic arterial blood pressure mediated by a chemical signal fructose transmembrane transporter activity glucose transmembrane transporter activity plasma membrane integral component of plasma membrane carbohydrate transport response to fructose fructose transport membrane integral component of membrane apical plasma membrane transmembrane transporter activity sarcolemma transmembrane transport fructose binding cellular response to fructose stimulus glucose transmembrane transport fructose import across plasma membrane uc008vxk.1 uc008vxk.2 uc008vxk.3 
ENSMUST00000030834.7 Nos3 ENSMUST00000030834.7 nitric oxide synthase 3, endothelial cell (from RefSeq NM_008713.4) ENSMUST00000030834.1 ENSMUST00000030834.2 ENSMUST00000030834.3 ENSMUST00000030834.4 ENSMUST00000030834.5 ENSMUST00000030834.6 Ecnos NM_008713 NOS3_MOUSE Nos3 O55056 P70313 Q7TSV7 uc008wrd.1 uc008wrd.2 uc008wrd.3 uc008wrd.4 Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. May play a significant role in normal and abnormal limb development. Reaction=H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide; Xref=Rhea:RHEA:19897, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16480, ChEBI:CHEBI:32682, ChEBI:CHEBI:57743, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.39; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19898; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD. ; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Note=Binds 1 FMN. ; Name=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin; Xref=ChEBI:CHEBI:59560; Evidence=; Note=Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme. ; Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN (By similarity). Homodimer. Interacts with NOSIP and NOSTRIN (By similarity). Interacts with HSP90AB1 (By similarity). Forms a complex with ASL, ASS1 and SLC7A1; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway. Membrane, caveola Cytoplasm, cytoskeleton Golgi apparatus Cell membrane Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle, which is favored by interaction with NOSIP and results in a reduced enzymatic activity. Phosphorylation by AMPK at Ser-1176 in the presence of Ca(2+)- calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-494, resulting in inhibition of activity (By similarity). Belongs to the NOS family. angiogenesis ovulation from ovarian follicle in utero embryonic development blood vessel remodeling regulation of sodium ion transport regulation of the force of heart contraction by chemical signal regulation of systemic arterial blood pressure by endothelin aortic valve morphogenesis pulmonary valve morphogenesis endocardial cushion morphogenesis actin binding actin monomer binding NADPH-hemoprotein reductase activity nitric-oxide synthase activity calmodulin binding nucleus nucleolus cytoplasm mitochondrion Golgi apparatus cytosol cytoskeleton plasma membrane caveola arginine catabolic process nitric oxide biosynthetic process signal transduction nitric oxide mediated signal transduction beta-catenin binding negative regulation of cell proliferation response to hormone FMN binding positive regulation of gene expression vesicle membrane negative regulation of muscle hyperplasia smooth muscle hyperplasia membrane oxidoreductase activity removal of superoxide radicals heme binding lung development positive regulation of guanylate cyclase activity regulation of neurological system process lipopolysaccharide-mediated signaling pathway response to estradiol response to lipopolysaccharide response to fluid shear stress tetrahydrobiopterin binding arginine binding sarcolemma positive regulation of apoptotic process negative regulation of potassium ion transport positive regulation of blood vessel endothelial cell migration endothelial cell migration membrane raft apical part of cell cadherin binding positive regulation of angiogenesis negative regulation of blood pressure metal ion binding negative regulation of smooth muscle cell proliferation homeostasis of number of cells within a tissue flavin adenine dinucleotide binding NADP binding nitric-oxide synthase binding negative regulation of hydrolase activity Hsp90 protein binding negative regulation of calcium ion transport oxidation-reduction process ventricular septum morphogenesis negative regulation of biomineral tissue development cellular response to mechanical stimulus cellular response to transforming growth factor beta stimulus scaffold protein binding regulation of blood vessel diameter uc008wrd.1 uc008wrd.2 uc008wrd.3 uc008wrd.4 
ENSMUST00000030839.13 Ctnnbip1 ENSMUST00000030839.13 catenin beta interacting protein 1, transcript variant 1 (from RefSeq NM_023465.4) CNBP1_MOUSE Catnbip1 ENSMUST00000030839.1 ENSMUST00000030839.10 ENSMUST00000030839.11 ENSMUST00000030839.12 ENSMUST00000030839.2 ENSMUST00000030839.3 ENSMUST00000030839.4 ENSMUST00000030839.5 ENSMUST00000030839.6 ENSMUST00000030839.7 ENSMUST00000030839.8 ENSMUST00000030839.9 Icat NM_023465 Q9JJN6 uc008vwm.1 uc008vwm.2 uc008vwm.3 uc008vwm.4 Prevents the interaction between CTNNB1 and TCF family members, and acts as a negative regulator of the Wnt signaling pathway. Binds CTNNB1. Cytoplasm. Nucleus. Highly expressed in heart, brain, liver and skeletal muscle. Detected at low levels in kidney, testis and lung. Belongs to the CTNNBIP1 family. negative regulation of transcription from RNA polymerase II promoter branching involved in ureteric bud morphogenesis regulation of vascular permeability involved in acute inflammatory response protein binding nucleus cytoplasm cytosol beta-catenin binding anterior/posterior pattern specification Wnt signaling pathway negative regulation of Wnt signaling pathway beta-catenin destruction complex negative regulation of protein complex assembly negative regulation of protein binding negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of monocyte differentiation positive regulation of osteoblast differentiation negative regulation of smooth muscle cell proliferation negative regulation of transcription initiation from RNA polymerase II promoter armadillo repeat domain binding negative regulation of mesenchymal cell proliferation uc008vwm.1 uc008vwm.2 uc008vwm.3 uc008vwm.4 
ENSMUST00000030840.4 Angptl7 ENSMUST00000030840.4 angiopoietin-like 7 (from RefSeq NM_001039554.3) ANGL7_MOUSE ENSMUST00000030840.1 ENSMUST00000030840.2 ENSMUST00000030840.3 NM_001039554 Q8R1Q3 uc008vus.1 uc008vus.2 uc008vus.3 Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (By similarity). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed:25622036). Homotetramer; disulfide-linked. Secreted cellular_component extracellular region uc008vus.1 uc008vus.2 uc008vus.3 
ENSMUST00000030841.10 Klhl7 ENSMUST00000030841.10 kelch-like 7, transcript variant 1 (from RefSeq NM_026448.3) ENSMUST00000030841.1 ENSMUST00000030841.2 ENSMUST00000030841.3 ENSMUST00000030841.4 ENSMUST00000030841.5 ENSMUST00000030841.6 ENSMUST00000030841.7 ENSMUST00000030841.8 ENSMUST00000030841.9 KLHL7_MOUSE NM_026448 Q8BUL5 Q9CZP4 uc008wqy.1 uc008wqy.2 uc008wqy.3 uc008wqy.4 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination (By similarity). Protein modification; protein ubiquitination. Homodimer. Component of the BCR(KLHL7) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL7 and RBX1 (By similarity). Nucleus Cytoplasm Note=Colocalizes with CUL3 in punctate structures at the perinuclear region of the cytoplasm. nucleus nucleoplasm nucleolus cytoplasm cytosol plasma membrane protein ubiquitination Cul3-RING ubiquitin ligase complex identical protein binding protein homodimerization activity perinuclear region of cytoplasm uc008wqy.1 uc008wqy.2 uc008wqy.3 uc008wqy.4 
ENSMUST00000030842.8 Lzic ENSMUST00000030842.8 leucine zipper and CTNNBIP1 domain containing, transcript variant 1 (from RefSeq NM_026963.6) ENSMUST00000030842.1 ENSMUST00000030842.2 ENSMUST00000030842.3 ENSMUST00000030842.4 ENSMUST00000030842.5 ENSMUST00000030842.6 ENSMUST00000030842.7 LZIC_MOUSE NM_026963 Q8K3C3 Q9D8V3 uc008vwl.1 uc008vwl.2 uc008vwl.3 uc008vwl.4 Does not interact with CTNNB1. Belongs to the CTNNBIP1 family. molecular_function cellular_component beta-catenin binding response to ionizing radiation uc008vwl.1 uc008vwl.2 uc008vwl.3 uc008vwl.4 
ENSMUST00000030845.13 Nmnat1 ENSMUST00000030845.13 nicotinamide nucleotide adenylyltransferase 1, transcript variant 1 (from RefSeq NM_133435.2) D4Cole1e ENSMUST00000030845.1 ENSMUST00000030845.10 ENSMUST00000030845.11 ENSMUST00000030845.12 ENSMUST00000030845.2 ENSMUST00000030845.3 ENSMUST00000030845.4 ENSMUST00000030845.5 ENSMUST00000030845.6 ENSMUST00000030845.7 ENSMUST00000030845.8 ENSMUST00000030845.9 NMNA1_MOUSE NM_133435 Nmnat Q6B504 Q9EPA7 uc008vwj.1 uc008vwj.2 uc008vwj.3 Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:15381699, PubMed:27735788). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (By similarity). Can use triazofurin monophosphate (TrMP) as substrate (By similarity). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (By similarity). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (By similarity). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (By similarity). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Also acts as a cofactor for glutamate and aspartate ADP- ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones (PubMed:32822587). Protects against axonal degeneration following mechanical or toxic insults (PubMed:15310905, PubMed:16914673). Delays axonal degeneration after axotomy. Results in a >10-fold increase in intact neurites 72 hours after injury (PubMed:16914673, PubMed:27735788). Reaction=ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+); Xref=Rhea:RHEA:21360, ChEBI:CHEBI:14649, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57540; EC=2.7.7.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21361; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21362; Evidence=; Reaction=ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate; Xref=Rhea:RHEA:22860, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57502, ChEBI:CHEBI:58437; EC=2.7.7.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22861; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22862; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Divalent metal cations. Zn(2+) confers higher activity as compared to Mg(2+). ; Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')- tetraphosphate (Nap4AD). Kinetic parameters: KM=20.1 uM for nicotinamide mononucleotide (NMN) ; Vmax=34.1 umol/min/mg enzyme ; Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. Homohexamer (By similarity). Interacts with ADPRT/PARP1 (PubMed:32822587). Nucleus Expressed throughout development and in adulthood. By neuronal injury. In strain C57BL/Ola, an 85 kb region on chromosome 4 containing Nmnat1 and Ube4b is triplicated. The N-terminal 70 residues of Ube4b becomes linked to the complete Nmnat1 protein and encodes a fusion protein located in the nucleus which is responsible for the Wallerian degeneration slow (Wlds) phenotype characterized by delayed Wallerian degeneration of injured axons. Belongs to the eukaryotic NMN adenylyltransferase family. Sequence=AAG17285.1; Type=Erroneous initiation; Evidence=; Sequence=AAG17286.1; Type=Erroneous initiation; Evidence=; Sequence=AAG38490.1; Type=Erroneous initiation; Evidence=; nucleotide binding nicotinamide-nucleotide adenylyltransferase activity catalytic activity nicotinate-nucleotide adenylyltransferase activity ATP binding nucleus nucleoplasm cytoplasm biosynthetic process NAD biosynthetic process response to wounding nuclear body transferase activity nucleotidyltransferase activity pyridine nucleotide biosynthetic process identical protein binding positive regulation of MAPK cascade negative regulation of neuron apoptotic process negative regulation of apoptotic DNA fragmentation ATP generation from poly-ADP-D-ribose uc008vwj.1 uc008vwj.2 uc008vwj.3 
ENSMUST00000030848.3 Rbp7 ENSMUST00000030848.3 retinol binding protein 7, cellular (from RefSeq NM_022020.2) ENSMUST00000030848.1 ENSMUST00000030848.2 NM_022020 Q9CTK0 Q9EPC5 RET7_MOUSE uc008vwh.1 uc008vwh.2 uc008vwh.3 uc008vwh.4 Intracellular transport of retinol. Cytoplasm Highly expressed in white adipose tissue and mammary gland. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. retinoid binding cytoplasm lipid binding retinal binding retinol binding uc008vwh.1 uc008vwh.2 uc008vwh.3 uc008vwh.4 
ENSMUST00000030851.7 Tomm7 ENSMUST00000030851.7 translocase of outer mitochondrial membrane 7 (from RefSeq NM_025394.3) ENSMUST00000030851.1 ENSMUST00000030851.2 ENSMUST00000030851.3 ENSMUST00000030851.4 ENSMUST00000030851.5 ENSMUST00000030851.6 NM_025394 Q9D173 TOM7_MOUSE uc008wqs.1 uc008wqs.2 uc008wqs.3 uc008wqs.4 Required for assembly and stability of the TOM complex (By similarity). Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity). Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Mitochondrion outer membrane ; Single-pass membrane protein Belongs to the Tom7 family. mitochondrion mitochondrial outer membrane mitochondrial outer membrane translocase complex protein transport membrane integral component of membrane protein import into mitochondrial matrix regulation of protein stability mitophagy in response to mitochondrial depolarization positive regulation of protein targeting to mitochondrion uc008wqs.1 uc008wqs.2 uc008wqs.3 uc008wqs.4 
ENSMUST00000030852.13 Rint1 ENSMUST00000030852.13 RAD50 interactor 1, transcript variant 1 (from RefSeq NM_177323.4) ENSMUST00000030852.1 ENSMUST00000030852.10 ENSMUST00000030852.11 ENSMUST00000030852.12 ENSMUST00000030852.2 ENSMUST00000030852.3 ENSMUST00000030852.4 ENSMUST00000030852.5 ENSMUST00000030852.6 ENSMUST00000030852.7 ENSMUST00000030852.8 ENSMUST00000030852.9 NM_177323 Q3UXS1 Q6P1I2 Q8BZ36 Q8C193 RINT1_MOUSE uc008wqq.1 uc008wqq.2 uc008wqq.3 Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control (By similarity). Component of the NRZ complex composed of NBAS, ZW10 and RINT1/TIP20L; NRZ associates with SNAREs STX18, USE1L, BNIP1/SEC20L and SEC22B (the assembly has been described as syntaxin 18 complex). Interacts directly with BNIP1/SEC20L and ZW10. Interacts with RAD50 during late S and G2/M phases. Interacts with RBL2, preferentially with the active, hypophosphorylated form (By similarity). Cytoplasm Endoplasmic reticulum membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZ36-1; Sequence=Displayed; Name=2; IsoId=Q8BZ36-2; Sequence=VSP_012658; Belongs to the RINT1 family. Sequence=BAC29582.1; Type=Frameshift; Evidence=; cytoplasm endoplasmic reticulum endoplasmic reticulum membrane retrograde vesicle-mediated transport, Golgi to ER cell cycle protein transport membrane vesicle-mediated transport Golgi vesicle transport regulation of ER to Golgi vesicle-mediated transport Dsl1/NZR complex regulation of signal transduction involved in mitotic G2 DNA damage checkpoint uc008wqq.1 uc008wqq.2 uc008wqq.3 
ENSMUST00000030862.5 Draxin ENSMUST00000030862.5 dorsal inhibitory axon guidance protein (from RefSeq NM_027426.3) A2A7G4 B2KFL9 DRAXI_MOUSE ENSMUST00000030862.1 ENSMUST00000030862.2 ENSMUST00000030862.3 ENSMUST00000030862.4 NM_027426 Q6PAL1 Q8C3D8 uc008vua.1 uc008vua.2 uc008vua.3 Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. Interacts with LRP6. Secreted In embryonic brain, strong expression in the olfactory bulb, anterior olfactory nucleus, neocortex, piriform cortex, glial wedge, midline zipper glia, indusium griseum and the area surrounding the anterior commissure (AC) but not on AC axons (at protein level) (PubMed:23206892). Predominantly expressed in developing neural tissues. Expressed in many brain regions, including the olfactory bulb, cortex, midbrain, cerebellum and pontine nuclei in neonates. Detected in the dorsal spinal cord and commissural axons. In the forebrain commissures, it is expressed in the regions that surround the corpus callosum, hippocampal commissure, and anterior commissure, such as the midline glial cells, indusium griseum glia, and glial wedge. Mice are viable and fertile (PubMed:19150847). They however show a defasciculation of spinal cord commissural axons and absence of all forebrain commissures (PubMed:19150847, PubMed:23206892). Double knockout of Tsku and Draxi results in a higher frequency of anterior commissure defects than single knockout of either Tsku or Draxi (PubMed:23206892). Belongs to the draxin family. protein binding extracellular region multicellular organism development axon guidance Wnt signaling pathway dorsal spinal cord development commissural neuron differentiation in spinal cord negative regulation of axon extension forebrain development negative regulation of neuron apoptotic process negative regulation of canonical Wnt signaling pathway uc008vua.1 uc008vua.2 uc008vua.3 
ENSMUST00000030865.9 Agtrap ENSMUST00000030865.9 angiotensin II, type I receptor-associated protein, transcript variant 1 (from RefSeq NM_009642.5) ATRAP_MOUSE Atrap B2KFL8 ENSMUST00000030865.1 ENSMUST00000030865.2 ENSMUST00000030865.3 ENSMUST00000030865.4 ENSMUST00000030865.5 ENSMUST00000030865.6 ENSMUST00000030865.7 ENSMUST00000030865.8 NM_009642 Q3U7X6 Q9D8Z8 Q9D940 Q9WVK0 uc008vtz.1 uc008vtz.2 uc008vtz.3 Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. Interacts with RACK1 (By similarity), and with the C-terminal region of AGTR1. Q9WVK0; P29754: Agtr1a; NbExp=5; IntAct=EBI-645964, EBI-765178; Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles. Ubiquitous but more abundant in kidney, testis and heart. Golgi membrane response to hypoxia angiotensin type II receptor activity protein binding nucleoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol plasma membrane cell cortex regulation of blood pressure membrane integral component of membrane cytoplasmic vesicle membrane cytoplasmic vesicle angiotensin-activated signaling pathway intracellular membrane-bounded organelle uc008vtz.1 uc008vtz.2 uc008vtz.3 
ENSMUST00000030868.11 Sema3d ENSMUST00000030868.11 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D (from RefSeq NM_028882.4) ENSMUST00000030868.1 ENSMUST00000030868.10 ENSMUST00000030868.2 ENSMUST00000030868.3 ENSMUST00000030868.4 ENSMUST00000030868.5 ENSMUST00000030868.6 ENSMUST00000030868.7 ENSMUST00000030868.8 ENSMUST00000030868.9 NM_028882 Q8BH34 SEM3D_MOUSE uc008wly.1 uc008wly.2 uc008wly.3 uc008wly.4 Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity). Secreted Strong binding to neuropilin is mediated by the carboxy third of the protein. Belongs to the semaphorin family. neural crest cell migration extracellular region extracellular space integral component of plasma membrane multicellular organism development nervous system development axon guidance cell differentiation semaphorin receptor binding positive regulation of cell migration chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway uc008wly.1 uc008wly.2 uc008wly.3 uc008wly.4 
ENSMUST00000030872.12 Orc5 ENSMUST00000030872.12 origin recognition complex, subunit 5 (from RefSeq NM_011959.3) ENSMUST00000030872.1 ENSMUST00000030872.10 ENSMUST00000030872.11 ENSMUST00000030872.2 ENSMUST00000030872.3 ENSMUST00000030872.4 ENSMUST00000030872.5 ENSMUST00000030872.6 ENSMUST00000030872.7 ENSMUST00000030872.8 ENSMUST00000030872.9 NM_011959 ORC5_MOUSE Orc5l Q3TMI6 Q9WUV0 uc008wpq.1 uc008wpq.2 uc008wpq.3 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Nucleus Chromosome Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle. Belongs to the ORC5 family. nucleotide binding chromatin origin recognition complex DNA replication origin binding ATP binding nucleus nuclear origin of replication recognition complex cytosol DNA replication DNA replication initiation regulation of DNA replication uc008wpq.1 uc008wpq.2 uc008wpq.3 
ENSMUST00000030878.8 Slc26a5 ENSMUST00000030878.8 solute carrier family 26, member 5, transcript variant 1 (from RefSeq NM_030727.5) ENSMUST00000030878.1 ENSMUST00000030878.2 ENSMUST00000030878.3 ENSMUST00000030878.4 ENSMUST00000030878.5 ENSMUST00000030878.6 ENSMUST00000030878.7 NM_030727 Pres Q80ZB1 Q99NH7 S26A5_MOUSE Slc26a5 uc008wpg.1 uc008wpg.2 uc008wpg.3 uc008wpg.4 Voltage-sensitive motor protein that drives outer hair cell (OHC) electromotility (eM) and participates in sound amplification in the hearing organ (PubMed:12239568). Converts changes in the transmembrane electric potential into mechanical displacements resulting in the coupling of its expansion to movement of a charged voltage sensor across the lipid membrane (PubMed:12239568). The nature of the voltage sensor is not completely clear, and two models compete (By similarity). In the first model, acts as an incomplete transporter where intracellular chloride anion acts as extrinsic voltage sensor that drives conformational change in the protein which is sufficient to produce a length change in the plane of the membrane and hence in the length of the OHC (By similarity). The second model in which multiple charged amino acid residues are distributed at the intracellular and extracellular membrane interfaces that form an intrinsic voltage sensor, whose movement produces the non-linear capacitance (NLC) (By similarity). However, the effective voltage sensor may be the result of a hybrid voltage sensor, assembled from intrinsic charge (charged residues) and extrinsic charge (bound anion) (By similarity). Notably, binding of anions to the anion-binding pocket partially neutralizes the intrinsic positive charge rather than to form an electrically negative sensor, therefore remaining charge may serve as voltage sensor that, after depolarization, moves from down (expanded state) to up (contracted) conformation, which is accompanied by an eccentric contraction of the intermembrane cross-sectional area of the protein as well as a major increase in the hydrophobic thickness of the protein having as consequences the plasma membrane thickening and the cell contraction after membrane depolarization (By similarity). The anion- binding pocket transits from the inward-open (Down) state, where it is exposed toward the intracellular solvent in the absence of anion, to the occluded (Up) state upon anion binding (By similarity). Salicylate competes for the anion-binding site and inhibits the voltage-sensor movement, and therefore inhibits the charge transfer and electromotility by displacing Cl(-) from the anion-binding site and by preventing the structural transitions to the contracted state (By similarity). In addition, can act as a weak Cl(-)/HCO3(-) antiporter across the cell membrane and so regulate the intracellular pH of the outer hair cells (OHCs), while firstly found as being unable to mediate electrogenic anion transport (By similarity). Moreover, supports a role in cardiac mechanical amplification serving as an elastic element to enhance the actomyosin- based sarcomere contraction system (PubMed:33951436). Reaction=chloride(out) + 2 hydrogencarbonate(in) = chloride(in) + 2 hydrogencarbonate(out); Xref=Rhea:RHEA:72207, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996; Evidence=; Homodimer (By similarity). Interacts (via STAS domain) with CALM; this interaction is calcium-dependent and the STAS domain interacts with only one lobe of CALM which is an elongated conformation (By similarity). Lateral cell membrane ; Multi-pass membrane protein Note=Localized at the outer hair cells (OHC) lateral plasma membrane (PubMed:14553901, PubMed:12584604). Alters profoundly the shape of its surrounding lipid bilayer (By similarity). Expressed in the outer hair cells (OHC) of the organ of Corti of the inner ear (PubMed:14553901, PubMed:12584604, PubMed:12782792). Also weak expression in brain and testis (PubMed:12584604). Very weakly expressed in heart, spleen, muscle and lactating mammary glands (PubMed:12584604). Expressed in cardiac myocytes (at protein level), both in the surface sarcolemma and along the t-tubule (PubMed:33951436). Weakly expressed in skeletal muscle cells (at protein level) (PubMed:33951436). The STAS domain mediates dimerization, with both STAS domains latched onto each other in a domain-swapped manner. The N-terminus domain is involved in dimerization such that each N-terminus domain embraces both STAS domains (By similarity). The STAS domain harbors a unique anion-binding site important for the fine regulation of the high-frequency electromotile properties (By similarity). The transmembrane domain consists of 14 transmembrane segments organized in a 7(+)7 inverted repeat architecture that can be divided into two main helix bundles, the ''core'' domain and the ''gate'' domain (By similarity). The transmembrane regions are domain-swapped with the STAS domain containing N- and C-terminal cytoplasmic domains (By similarity). The STAS domain mediates CALM binding CALM (By similarity). Homozygous knockout mice lacking Slc26a5 have no obvious developmental or behavioral abnormalities, except that, at one month, mice show small size difference compared to wild-type (PubMed:12239568). Mice show loss of electromotility, shortened outer hair cells (OHCs), and a reduction of hearing sensitivity of 40-60 dB (PubMed:12239568). Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Name=Protein Spotlight; Note=Pump up the volume - Issue 22 of May 2002; URL="https://web.expasy.org/spotlight/back_issues/022"; response to ischemia cytoplasm plasma membrane integral component of plasma membrane sensory perception of sound transcription factor binding secondary active sulfate transmembrane transporter activity sulfate transport regulation of cell shape response to salicylic acid response to auditory stimulus bicarbonate transmembrane transporter activity chloride transmembrane transporter activity sulfate transmembrane transporter activity anion:anion antiporter activity bicarbonate transport fructose transport membrane integral component of membrane basolateral plasma membrane lateral plasma membrane oxalate transmembrane transporter activity oxalate transport spectrin binding ion transmembrane transport negative regulation of ion transmembrane transport response to potassium ion regulation of membrane potential response to drug protein homodimerization activity positive regulation of cell size protein tetramerization transmembrane transport cochlea development response to thyroid hormone anion transmembrane transport response to salt sulfate transmembrane transport chloride transmembrane transport positive regulation of cell motility uc008wpg.1 uc008wpg.2 uc008wpg.3 uc008wpg.4 
ENSMUST00000030879.12 Clcn6 ENSMUST00000030879.12 chloride channel, voltage-sensitive 6 (from RefSeq NM_011929.3) Clcn6 ENSMUST00000030879.1 ENSMUST00000030879.10 ENSMUST00000030879.11 ENSMUST00000030879.2 ENSMUST00000030879.3 ENSMUST00000030879.4 ENSMUST00000030879.5 ENSMUST00000030879.6 ENSMUST00000030879.7 ENSMUST00000030879.8 ENSMUST00000030879.9 NM_011929 Q3UM91 Q3UM91_MOUSE uc008vts.1 uc008vts.2 uc008vts.3 uc008vts.4 This gene encodes a member of the ClC chloride channel and transporter family of proteins. The encoded protein may function as a vesicular Cl-/H+ antiporter. Homozygous knockout mice exhibit decreased pain sensitivity, behavioral abnormalities and features of lysosomal storage disease. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK165362.1, SRR1660813.17519.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ulti-pass membrane protein Belongs to the chloride channel (TC 2.A.49) family. Lacks conserved residue(s) required for the propagation of feature annotation. voltage-gated chloride channel activity ion transport chloride transport response to mechanical stimulus membrane integral component of membrane transmembrane transport chloride transmembrane transport uc008vts.1 uc008vts.2 uc008vts.3 uc008vts.4 
ENSMUST00000030882.12 Pmpcb ENSMUST00000030882.12 peptidase (mitochondrial processing) beta, transcript variant 3 (from RefSeq NR_184580.1) ENSMUST00000030882.1 ENSMUST00000030882.10 ENSMUST00000030882.11 ENSMUST00000030882.2 ENSMUST00000030882.3 ENSMUST00000030882.4 ENSMUST00000030882.5 ENSMUST00000030882.6 ENSMUST00000030882.7 ENSMUST00000030882.8 ENSMUST00000030882.9 MPPB_MOUSE NR_184580 Q9CXT8 uc008wox.1 uc008wox.2 uc008wox.3 Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (By similarity). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (By similarity). Reaction=Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.; EC=3.4.24.64; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Binding to PMPCA is required for catalytic activity. Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit. Mitochondrion matrix Belongs to the peptidase M16 family. catalytic activity endopeptidase activity metalloendopeptidase activity mitochondrion mitochondrial inner membrane mitochondrial matrix proteolysis protein processing involved in protein targeting to mitochondrion peptidase activity metallopeptidase activity hydrolase activity mitochondrial processing peptidase complex metal ion binding uc008wox.1 uc008wox.2 uc008wox.3 
ENSMUST00000030884.10 Mfn2 ENSMUST00000030884.10 mitofusin 2, transcript variant 3 (from RefSeq NM_001285921.1) A2A7Y7 A8Y5E4 ENSMUST00000030884.1 ENSMUST00000030884.2 ENSMUST00000030884.3 ENSMUST00000030884.4 ENSMUST00000030884.5 ENSMUST00000030884.6 ENSMUST00000030884.7 ENSMUST00000030884.8 ENSMUST00000030884.9 Kiaa0214 MFN2_MOUSE Marf NM_001285921 Q3V3B8 Q80U63 Q80WP4 Q80XK3 Q8BHF0 Q8BKV5 Q8R535 Q923X2 uc008vti.1 uc008vti.2 uc008vti.3 uc008vti.4 Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:23921378, PubMed:23620051). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (PubMed:23921556). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (PubMed:23921556). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Forms homomultimers and heteromultimers with MFN1 (PubMed:12527753). Oligomerization is essential for mitochondrion fusion (Probable). Interacts with VAT1 (By similarity). Interacts with STOML2; may form heterooligomers (By similarity). Interacts (phosphorylated) with PRKN (PubMed:23620051). Interacts with EIF2AK3 (By similarity). Interacts with THG1L; THG1L probably functions as a guanyl-nucleotide exchange factor/GEF, activating MFN2. Q80U63; O08734: Bak1; NbExp=2; IntAct=EBI-8437663, EBI-822441; Q80U63; Q9Z2B5: Eif2ak3; NbExp=2; IntAct=EBI-8437663, EBI-1226344; Q80U63; Q16611: BAK1; Xeno; NbExp=3; IntAct=EBI-8437663, EBI-519866; Mitochondrion outer membrane ; Multi-pass membrane protein Note=Colocalizes with BAX during apoptosis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80U63-1; Sequence=Displayed; Name=2; IsoId=Q80U63-2; Sequence=VSP_010365, VSP_010366; Ubiquitous. Expression is markedly reduced in ApoE- knockout mouse atherosclerotic arteries. A helix bundle is formed by helices from the N-terminal and the C-terminal part of the protein. The GTPase domain cannot be expressed by itself, without the helix bundle. Rearrangement of the helix bundle and/or of the coiled coil domains may bring membranes from adjacent mitochondria into close contact, and thereby play a role in mitochondrial fusion. Phosphorylated by PINK1. Ubiquitinated by non-degradative ubiquitin by PRKN, promoting mitochondrial fusion; deubiquitination by USP30 inhibits mitochondrial fusion (PubMed:23620051, PubMed:24513856). Ubiquitinated by HUWE1 when dietary stearate (C18:0) levels are low; ubiquitination inhibits mitochondrial fusion (By similarity). Mutant mice die early during embryonic development (PubMed:12527753). Heart-specific disruption causes cardiomyopathy in aging mice, characterized by dilated hearts that are insensitive to beta-adrenergic stimulation and impaired contractile performance (PubMed:23620051). Mutant cardiomyocytes display mitochondrial enlargement with respiratory impairment (PubMed:23620051). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. Sequence=BAC65502.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding blastocyst formation GTPase activity protein binding GTP binding cytoplasm mitochondrion mitochondrial outer membrane cytosol protein targeting to mitochondrion autophagy apoptotic process response to unfolded protein mitochondrial membrane organization multicellular organism development mitochondrial fusion microtubule cytoskeleton membrane integral component of membrane hydrolase activity Ras GTPase binding intrinsic component of mitochondrial outer membrane ubiquitin protein ligase binding protein localization to pre-autophagosomal structure protein homodimerization activity proteoglycan binding negative regulation of Ras protein signal transduction camera-type eye morphogenesis negative regulation of smooth muscle cell proliferation GTPase binding mitochondrion localization parkin-mediated mitophagy in response to mitochondrial depolarization positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell apoptotic process cell cycle arrest uc008vti.1 uc008vti.2 uc008vti.3 uc008vti.4 
ENSMUST00000030893.3 Dffb ENSMUST00000030893.3 DNA fragmentation factor, beta subunit (from RefSeq NM_007859.4) Cad DFFB_MOUSE ENSMUST00000030893.1 ENSMUST00000030893.2 NM_007859 O54788 uc008wav.1 uc008wav.2 uc008wav.3 uc008wav.4 Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. Inhibited by DFFA (DFF45). Heterodimer of DFFA and DFFB (By similarity). Interacts with H1-1 (By similarity). O54788; O54786: Dffa; NbExp=7; IntAct=EBI-7365197, EBI-1634519; O54788; Q9D1C8: Vps28; NbExp=6; IntAct=EBI-7365197, EBI-309205; O54788; O00273: DFFA; Xeno; NbExp=8; IntAct=EBI-7365197, EBI-727171; Cytoplasm. Nucleus. nuclear chromatin DNA binding nuclease activity deoxyribonuclease activity protein binding nucleus nucleolus cytoplasm cytosol DNA catabolic process apoptotic DNA fragmentation apoptotic process hydrolase activity enzyme binding protein domain specific binding apoptotic chromosome condensation identical protein binding protein homooligomerization disordered domain specific binding uc008wav.1 uc008wav.2 uc008wav.3 uc008wav.4 
ENSMUST00000030895.12 Wrap73 ENSMUST00000030895.12 WD repeat containing, antisense to Trp73 (from RefSeq NM_021499.2) Dd57 ENSMUST00000030895.1 ENSMUST00000030895.10 ENSMUST00000030895.11 ENSMUST00000030895.2 ENSMUST00000030895.3 ENSMUST00000030895.4 ENSMUST00000030895.5 ENSMUST00000030895.6 ENSMUST00000030895.7 ENSMUST00000030895.8 ENSMUST00000030895.9 NM_021499 Q8BQ21 Q9JM98 WRP73_MOUSE Wdr8 uc008wbi.1 uc008wbi.2 uc008wbi.3 The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (By similarity). Interacts with SSX2IP (PubMed:26675238). Q9JM98; Q9Y2D8: SSX2IP; Xeno; NbExp=3; IntAct=EBI-11694665, EBI-2212028; Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Enriched in the proximal end of the mother centriole. During ciliogenesis also associated with the basal body of the adjacent centriole (By similarity). Ubiquitous. protein binding cytoplasm centrosome microtubule organizing center cytoskeleton cell projection organization ciliary basal body mitotic spindle assembly positive regulation of non-motile cilium assembly uc008wbi.1 uc008wbi.2 uc008wbi.3 
ENSMUST00000030896.15 Tprg1l ENSMUST00000030896.15 transformation related protein 63 regulated 1 like, transcript variant 2 (from RefSeq NR_151647.1) B1AX99 ENSMUST00000030896.1 ENSMUST00000030896.10 ENSMUST00000030896.11 ENSMUST00000030896.12 ENSMUST00000030896.13 ENSMUST00000030896.14 ENSMUST00000030896.2 ENSMUST00000030896.3 ENSMUST00000030896.4 ENSMUST00000030896.5 ENSMUST00000030896.6 ENSMUST00000030896.7 ENSMUST00000030896.8 ENSMUST00000030896.9 Fam79a Mover NR_151647 Q8BTC6 Q9DBS2 TPRGL_MOUSE Tprg1l Tprgl uc008wbm.1 uc008wbm.2 uc008wbm.3 uc008wbm.4 Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release. Forms homomultimers (By similarity). Multimerization appears to be important for presynaptic targeting (By similarity). Interacts with BSN (PubMed:17869247). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein Presynaptic active zone Phosphorylated. Phosphorylation promotes association with synaptic vesicle membranes. Belongs to the TPRG1 family. cytoplasm synaptic vesicle biological_process membrane cell junction synaptic vesicle membrane cytoplasmic vesicle identical protein binding calyx of Held synapse regulation of synaptic transmission, glutamatergic uc008wbm.1 uc008wbm.2 uc008wbm.3 uc008wbm.4 
ENSMUST00000030897.15 Megf6 ENSMUST00000030897.15 multiple EGF-like-domains 6 (from RefSeq NM_001162977.1) A0A0A0MQ83 A0A0A0MQ83_MOUSE ENSMUST00000030897.1 ENSMUST00000030897.10 ENSMUST00000030897.11 ENSMUST00000030897.12 ENSMUST00000030897.13 ENSMUST00000030897.14 ENSMUST00000030897.2 ENSMUST00000030897.3 ENSMUST00000030897.4 ENSMUST00000030897.5 ENSMUST00000030897.6 ENSMUST00000030897.7 ENSMUST00000030897.8 ENSMUST00000030897.9 Megf6 NM_001162977 uc008wbp.1 uc008wbp.2 uc008wbp.3 uc008wbp.4 Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding uc008wbp.1 uc008wbp.2 uc008wbp.3 uc008wbp.4 
ENSMUST00000030901.9 Ints11 ENSMUST00000030901.9 integrator complex subunit 11, transcript variant 7 (from RefSeq NR_185042.1) Cpsf3l ENSMUST00000030901.1 ENSMUST00000030901.2 ENSMUST00000030901.3 ENSMUST00000030901.4 ENSMUST00000030901.5 ENSMUST00000030901.6 ENSMUST00000030901.7 ENSMUST00000030901.8 INT11_MOUSE NR_185042 Q3TJ34 Q3U7B0 Q91X99 Q922F0 Q9CWS4 uc008wfh.1 uc008wfh.2 uc008wfh.3 Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Nucleus Cytoplasm The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. INTS11 subfamily. Sequence=AAH08240.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleus nucleoplasm cytoplasm cytosol snRNA processing hydrolase activity integrator complex uc008wfh.1 uc008wfh.2 uc008wfh.3 
ENSMUST00000030903.12 Atad3a ENSMUST00000030903.12 ATPase family, AAA domain containing 3A (from RefSeq NM_179203.3) A2AD89 ATAD3_MOUSE Atad3 ENSMUST00000030903.1 ENSMUST00000030903.10 ENSMUST00000030903.11 ENSMUST00000030903.2 ENSMUST00000030903.3 ENSMUST00000030903.4 ENSMUST00000030903.5 ENSMUST00000030903.6 ENSMUST00000030903.7 ENSMUST00000030903.8 ENSMUST00000030903.9 Kiaa1273 NM_179203 Q3TA78 Q3UE74 Q69ZM7 Q8C6C6 Q925I1 uc008wen.1 uc008wen.2 uc008wen.3 uc008wen.4 Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity. Can form homooligomers. Homodimer formation at the N-terminus may be regulated by ATP and is required for the interaction with the inner surface of the mitochondrial outer membrane and correct mitochondrial homeostasis. Interacts with components of the mitochondrial ribosome and with other proteins involved in mitochondrial RNA metabolism. May also interact with protein involved in lipid metabolism, including STARD9. May interact with FAM210A. Interacts with GADD45GIP1. Interacts with S100B in a Ca(+2)- and Zn(+2)-dependent manner; this interaction probably occurs in the cytosol prior to mitochondrial targeting. S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. Interacts with HSP60/HSPD1. Forms heterooligomers with ATAD3B; this interaction may affect ATAD3A activity. Interacts with CLPB. Q925I1; Q8K1M6: Dnm1l; NbExp=13; IntAct=EBI-772703, EBI-2365792; Mitochondrion inner membrane ; Single-pass membrane protein Mitochondrion matrix, mitochondrion nucleoid Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q925I1-1; Sequence=Displayed; Name=2; IsoId=Q925I1-2; Sequence=VSP_015643; Expressed in heart, spleen, kidney, liver and at smaller levels, in lung and muscle (at protein level). The transmembrane domain and a C-terminal adjacent region contain all information necessary for mitochondrial targeting. Belongs to the AAA ATPase family. nucleotide binding regulation of cell growth ATP binding mitochondrion mitochondrial inner membrane mitochondrion organization zinc ion binding membrane integral component of membrane mitochondrial nucleoid negative regulation of apoptotic process uc008wen.1 uc008wen.2 uc008wen.3 uc008wen.4 
ENSMUST00000030905.9 Ssu72 ENSMUST00000030905.9 Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) (from RefSeq NM_026899.3) ENSMUST00000030905.1 ENSMUST00000030905.2 ENSMUST00000030905.3 ENSMUST00000030905.4 ENSMUST00000030905.5 ENSMUST00000030905.6 ENSMUST00000030905.7 ENSMUST00000030905.8 NM_026899 Q3UF99 Q91YL1 Q9CY97 Q9DB51 SSU72_MOUSE uc008wel.1 uc008wel.2 uc008wel.3 uc008wel.4 uc008wel.5 Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Interacts with GTF2B (via C-terminus); this interaction is inhibited by SYMPK. Interacts with RB1. Interacts with CD226. Interacts with SYMPK. Nucleus Cytoplasm Note=Predominantly in the cytosol. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CY97-1; Sequence=Displayed; Name=2; IsoId=Q9CY97-2; Sequence=VSP_033006; Highly expressed in the brain. Expressed at low level in most tissues. At 10.5 dpc, low level expression detected throughout the embryo with relative accumulation in spinal cord and brain folds. At 13.5 dpc, highly expressed in the CNS both in the ventricular (mitotic) and marginal (post mitotic) zones, in the PNS in dorsal root and trigeminal ganglia, and the developing gut. During development, expression in the central nervous system and peripheral nervous system persists, and expression in the intestine is further induced. Expression in the intestine is observed throughout the mucosal villi, which contains epithelial cells and other cell types. High expression is also detected in the lens. No expression is seen in other tissues such as liver, lung, bone, cardiac and skeletal muscles. Belongs to the SSU72 phosphatase family. phosphoprotein phosphatase activity nucleus nucleoplasm cytoplasm cytosol mRNA cleavage and polyadenylation specificity factor complex termination of RNA polymerase II transcription mRNA polyadenylation mRNA processing CTD phosphatase activity hydrolase activity dephosphorylation of RNA polymerase II C-terminal domain uc008wel.1 uc008wel.2 uc008wel.3 uc008wel.4 uc008wel.5 
ENSMUST00000030914.4 Rer1 ENSMUST00000030914.4 retention in endoplasmic reticulum sorting receptor 1, transcript variant 1 (from RefSeq NM_026395.2) ENSMUST00000030914.1 ENSMUST00000030914.2 ENSMUST00000030914.3 NM_026395 Q3THP4 Q9CQU3 RER1_MOUSE uc008wct.1 uc008wct.2 uc008wct.3 Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. Golgi apparatus membrane ; Multi- pass membrane protein Belongs to the RER1 family. Golgi membrane endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus plasma membrane protein retention in ER lumen retrograde vesicle-mediated transport, Golgi to ER neuromuscular junction development cell surface membrane integral component of membrane integral component of Golgi membrane acetylcholine receptor binding skeletal muscle acetylcholine-gated channel clustering positive regulation of protein localization to plasma membrane uc008wct.1 uc008wct.2 uc008wct.3 
ENSMUST00000030915.11 Morn1 ENSMUST00000030915.11 MORN repeat containing 1, transcript variant 2 (from RefSeq NM_001356327.1) A2RTS7 A2RTS7_MOUSE ENSMUST00000030915.1 ENSMUST00000030915.10 ENSMUST00000030915.2 ENSMUST00000030915.3 ENSMUST00000030915.4 ENSMUST00000030915.5 ENSMUST00000030915.6 ENSMUST00000030915.7 ENSMUST00000030915.8 ENSMUST00000030915.9 Morn1 NM_001356327 uc008wcw.1 uc008wcw.2 uc008wcw.3 molecular_function cellular_component biological_process uc008wcw.1 uc008wcw.2 uc008wcw.3 
ENSMUST00000030917.6 Ski ENSMUST00000030917.6 ski sarcoma viral oncogene homolog (avian), transcript variant 1 (from RefSeq NM_011385.3) B1AUF1 B1AUF1_MOUSE ENSMUST00000030917.1 ENSMUST00000030917.2 ENSMUST00000030917.3 ENSMUST00000030917.4 ENSMUST00000030917.5 NM_011385 Ski uc008wcz.1 uc008wcz.2 uc008wcz.3 Belongs to the SKI family. negative regulation of transcription from RNA polymerase II promoter transcription corepressor activity nucleus nucleoplasm centrosome transcription, DNA-templated zinc ion binding negative regulation of cell proliferation negative regulation of Schwann cell proliferation myotube differentiation nuclear body PML body protein kinase binding protein domain specific binding negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway ubiquitin protein ligase binding negative regulation of activin receptor signaling pathway macromolecular complex positive regulation of DNA binding negative regulation of osteoblast differentiation SMAD binding SMAD protein signal transduction protein homotrimerization repressing transcription factor binding uc008wcz.1 uc008wcz.2 uc008wcz.3 
ENSMUST00000030922.15 Prkcz ENSMUST00000030922.15 protein kinase C, zeta, transcript variant 11 (from RefSeq NR_188944.1) A2AD76 ENSMUST00000030922.1 ENSMUST00000030922.10 ENSMUST00000030922.11 ENSMUST00000030922.12 ENSMUST00000030922.13 ENSMUST00000030922.14 ENSMUST00000030922.2 ENSMUST00000030922.3 ENSMUST00000030922.4 ENSMUST00000030922.5 ENSMUST00000030922.6 ENSMUST00000030922.7 ENSMUST00000030922.8 ENSMUST00000030922.9 KPCZ_MOUSE NR_188944 Pkcz Q02956 Q3UHM5 Q7TST7 uc008wdd.1 uc008wdd.2 uc008wdd.3 uc008wdd.4 Calcium- and diacylglycerol-independent serine/threonine- protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5- MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF- kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (By similarity). [Isoform 2]: Involved in late synaptic long term potentiation phase in CA1 hippocampal cells and long term memory maintenance. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=; Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn motif), need to be phosphorylated for its full activation. Phosphatidylinositol 3,4,5-trisphosphate might be a physiological activator (By similarity). Isoform 2: Constitutively active (By similarity). Interacts directly with SQSTM1. Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3. Forms a complex with SQSTM1 and MAP2K5 (By similarity). Interacts with PARD6A, PARD6B and PARD6G. Part of a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with ADAP1/CENTA1. Interacts (via the protein kinase domain) with WWC1. Forms a tripartite complex with WWC1 and DDR1, but predominantly in the absence of collagen. Interacts with PDPK1 (via N-terminal region) (By similarity). Interacts with WDFY2 (via WD repeats 1-3) (PubMed:16792529). Interacts with VAMP2 (PubMed:17313651). Forms a complex with WDFY2 and VAMP2 (PubMed:17313651). Interacts with APPL1 (By similarity). Interacts with WWC1, WWC2 and WWC3 (By similarity). Q02956; Q62151: Ager; NbExp=7; IntAct=EBI-642057, EBI-6665091; Cytoplasm Endosome Cell junction Membrane ; Peripheral membrane protein Note=In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associated with endosomes (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (By similarity). Colocalizes with VAMP2 and WDFY2 in intracellular vesicles (PubMed:17313651). Transiently translocates to the membrane of CA1 hippocampal cells in response to the induction of long term potentiation (By similarity). [Isoform 2]: Cytoplasm Event=Alternative promoter usage; Named isoforms=2; Name=1; IsoId=Q02956-1; Sequence=Displayed; Name=2; Synonyms=PKCzetaII , PMKzeta ; IsoId=Q02956-2; Sequence=VSP_059934; Isoform 1: In brain, highly expressed in cerebellar granule neurons and cerebellar astrocytes (at protein level) (PubMed:1487145, PubMed:12932816). Expressed at low levels in testes, lung and kidney (PubMed:1487145, PubMed:23283171). Isoform 2: Specifically expressed in brain where it localizes to cerebellar granule neurons (at protein level) (PubMed:12932816, PubMed:23283171). [Isoform 2]: Induced during synaptic long term potentiation. The C1 domain does not bind the diacylglycerol (DAG). The PB1 domain mediate mutually exclusive interactions with SQSTM1 and PARD6B. CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the kinase (By similarity). No visible phenotype (PubMed:23283171). Reduced anxiety-like behavior in males (PubMed:23283171). Does not affect long term memory maintenance (PubMed:23283171, PubMed:27187150). However, when the conditions during the establishment of memory are more demanding, spatial long term memory maintenance is slightly affected (PubMed:27187150). Up-regulation of PRKCI/PKCiota protein levels following induction of synaptic long term potentiation abnormally persist. This compensatory mechanism is responsible for the lack of defect in long term memory maintenance in absence of isoform 1 and isoform 2 (PubMed:27187150). Isoform 2: RNAi-mediated knockdown prevents late synaptic long term potentiation and spatial long term memory (PubMed:27187150). [Isoform 2]: Produced by alternative promoter usage. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. nucleotide binding microtubule cytoskeleton organization stress fiber positive regulation of cell-matrix adhesion protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding nucleus nuclear envelope cytoplasm endosome microtubule organizing center cytosol plasma membrane cell-cell junction bicellular tight junction cell cortex protein phosphorylation inflammatory response signal transduction cell surface receptor signaling pathway long-term memory positive regulation of cell proliferation postsynaptic density potassium channel regulator activity membrane kinase activity phosphorylation apical plasma membrane nuclear matrix cell migration transferase activity peptidyl-serine phosphorylation protein kinase binding establishment of cell polarity cell junction cell leading edge negative regulation of protein complex assembly activation of phospholipase D activity vesicle activation of protein kinase B activity positive regulation of interleukin-4 production cellular response to insulin stimulus cellular protein localization intracellular signal transduction myelin sheath abaxonal region negative regulation of apoptotic process axon hillock intracellular membrane-bounded organelle phospholipase binding membrane raft apical cortex positive regulation of T-helper 2 cell differentiation negative regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway metal ion binding vesicle transport along microtubule perinuclear region of cytoplasm negative regulation of peptidyl-tyrosine phosphorylation positive regulation of synaptic transmission positive regulation of NF-kappaB transcription factor activity positive regulation of protein transport protein heterooligomerization negative regulation of hydrolase activity membrane depolarization membrane hyperpolarization long-term synaptic potentiation positive regulation of ERK1 and ERK2 cascade protein kinase C signaling 14-3-3 protein binding protein localization to plasma membrane glutamatergic synapse neuron projection extension positive regulation of excitatory postsynaptic potential positive regulation of T-helper 2 cell cytokine production positive regulation of interleukin-5 secretion positive regulation of interleukin-13 secretion positive regulation of interleukin-10 secretion uc008wdd.1 uc008wdd.2 uc008wdd.3 uc008wdd.4 
ENSMUST00000030925.3 Gabrd ENSMUST00000030925.3 gamma-aminobutyric acid (GABA) A receptor, subunit delta, transcript variant 1 (from RefSeq NM_008072.3) ENSMUST00000030925.1 ENSMUST00000030925.2 Gabrd NM_008072 Q14AH9 Q14AH9_MOUSE uc008wdf.1 uc008wdf.2 uc008wdf.3 uc008wdf.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane ion transport chemical synaptic transmission membrane integral component of membrane ion transmembrane transport glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane uc008wdf.1 uc008wdf.2 uc008wdf.3 uc008wdf.4 
ENSMUST00000030931.11 Pank4 ENSMUST00000030931.11 pantothenate kinase 4, transcript variant 13 (from RefSeq NR_176007.1) B1AZN5 B1AZN6 ENSMUST00000030931.1 ENSMUST00000030931.10 ENSMUST00000030931.2 ENSMUST00000030931.3 ENSMUST00000030931.4 ENSMUST00000030931.5 ENSMUST00000030931.6 ENSMUST00000030931.7 ENSMUST00000030931.8 ENSMUST00000030931.9 NR_176007 PANK4_MOUSE Q7M751 Q80YV4 Q8BQE9 uc008wcl.1 uc008wcl.2 uc008wcl.3 uc008wcl.4 uc008wcl.5 Phosphatase which shows a preference for 4'- phosphopantetheine and its oxidatively damaged forms (sulfonate or S- sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels. Reaction=(R)-4'-phosphopantetheine + H2O = (R)-pantetheine + phosphate; Xref=Rhea:RHEA:68328, ChEBI:CHEBI:15377, ChEBI:CHEBI:16753, ChEBI:CHEBI:43474, ChEBI:CHEBI:61723; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68329; Evidence=; Reaction=(R)-4'-phosphopantetheine sulfonate + H2O = (R)-pantetheine sulfonate + phosphate; Xref=Rhea:RHEA:68336, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:177300, ChEBI:CHEBI:177301; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68337; Evidence=; Reaction=(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S- sulfopantetheine + phosphate; Xref=Rhea:RHEA:68340, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:177302, ChEBI:CHEBI:177303; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68341; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Evidence=; Activity is strongly promoted by Co(2+), Ni(2+), Mg(2+) and Mn(2+). Activity is inhibited by EDTA. Homodimer. Interacts with PKM. Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80YV4-1; Sequence=Displayed; Name=2; IsoId=Q80YV4-2; Sequence=VSP_020381; Name=3; IsoId=Q80YV4-3; Sequence=VSP_020379, VSP_020380; Expressed in liver, kidney, brain cortex and eye lens (at protein level). Subfamily II proteins have an EGMGR motif about 50 residues from the C-terminus (By similarity). This motif lies near the metal- binding residues in the putative substrate-binding cleft 2 (By similarity). Subfamily II proteins occur only in eukaryotes, in two forms: as a stand-alone unit in plants, and as a C-terminal domain of pantothenate kinases in plants, animals, and chytrid fungi (By similarity). Knockout mice have a body weight and a lifespan similar to wild-type animals. About 10% of the animals start developing cataract at 2 months. At 15 months, 50% homozygous animals are affected. Heterozygous animals develop cataract later, with 10% animals affected at 9 months and 25% at 15. In the N-terminal section; belongs to the type II pantothenate kinase family. In the C-terminal section; belongs to the damage-control phosphatase family. Phosphopantetheine phosphatase II subfamily. Despite belonging to the type II pantothenate kinase family, the pantothenate kinase domain contains a Val residue at position 147 and a Trp residue at position 211 instead of the two conserved active site residues, Glu and Arg. Lacks pantothenate kinase activity. nucleotide binding pantothenate kinase activity ATP binding nucleus cytoplasm cytosol coenzyme A biosynthetic process kinase activity phosphorylation transferase activity hydrolase activity metal ion binding uc008wcl.1 uc008wcl.2 uc008wcl.3 uc008wcl.4 uc008wcl.5 
ENSMUST00000030935.10 Prxl2b ENSMUST00000030935.10 peroxiredoxin like 2B (from RefSeq NM_025582.4) ENSMUST00000030935.1 ENSMUST00000030935.2 ENSMUST00000030935.3 ENSMUST00000030935.4 ENSMUST00000030935.5 ENSMUST00000030935.6 ENSMUST00000030935.7 ENSMUST00000030935.8 ENSMUST00000030935.9 Fam213b NM_025582 PXL2B_MOUSE Q9DB60 uc008wch.1 uc008wch.2 uc008wch.3 Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). Reaction=[thioredoxin]-dithiol + prostaglandin H2 = [thioredoxin]- disulfide + prostaglandin F2alpha; Xref=Rhea:RHEA:28214, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57404, ChEBI:CHEBI:57405; EC=1.11.1.20; Evidence=; Reaction=[thioredoxin]-disulfide + prostamide F2alpha = [thioredoxin]- dithiol + prostamide H2; Xref=Rhea:RHEA:26373, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:53081, ChEBI:CHEBI:53082; EC=1.11.1.20; Evidence=; Cytoplasm, cytosol Mainly present in brain and spinal cord. In spinal cord, present in the superficial layer of the dorsal horn, in motor neurons of the ventral horn and in glia of the white matter of the spinal cord. In brain, expressed preferentially in the white matter bundles of the entire CNS of adult with less marked expression in neuronal cell bodies. Colocalizes with MBP in myelin sheaths but not in axons. Localizes to myelin sheaths (at protein level). Belongs to the peroxiredoxin-like PRXL2 family. Prostamide/prostaglandin F synthase subfamily. prostaglandin biosynthetic process cytoplasm endoplasmic reticulum cytosol lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process thioredoxin peroxidase activity antioxidant activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor myelin sheath prostaglandin-F synthase activity oxidation-reduction process cellular oxidant detoxification uc008wch.1 uc008wch.2 uc008wch.3 
ENSMUST00000030937.2 Mmp23 ENSMUST00000030937.2 matrix metallopeptidase 23, transcript variant 1 (from RefSeq NM_011985.4) Cammp ENSMUST00000030937.1 MMP23_MOUSE NM_011985 O88676 Q3KNC0 uc008wed.1 uc008wed.2 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded protein contains an N-terminal cysteine array and a novel immunoglobulin-fold domain at the C-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, Feb 2016]. Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Inhibited by TIMP2. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Note=A secreted form produced by proteolytic cleavage may also exist. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88676-1; Sequence=Displayed; Name=2; IsoId=O88676-2; Sequence=VSP_021561; Expressed at relatively high level in heart, lung and spleen. Not detected in brain, liver, skeletal muscle, kidney and testis. Expressed at relatively high level at 7 days old embryo compared to those at stadges day 11, 15 and 17. The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity). N-glycosylated. Proteolytic cleavage might yield an active form. Belongs to the peptidase M10A family. reproduction metalloendopeptidase activity extracellular space endoplasmic reticulum endoplasmic reticulum membrane proteolysis peptidase activity metallopeptidase activity zinc ion binding membrane integral component of membrane hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix metal ion binding uc008wed.1 uc008wed.2 
ENSMUST00000030939.14 Nadk ENSMUST00000030939.14 NAD kinase, transcript variant 2 (from RefSeq NM_138671.3) ENSMUST00000030939.1 ENSMUST00000030939.10 ENSMUST00000030939.11 ENSMUST00000030939.12 ENSMUST00000030939.13 ENSMUST00000030939.2 ENSMUST00000030939.3 ENSMUST00000030939.4 ENSMUST00000030939.5 ENSMUST00000030939.6 ENSMUST00000030939.7 ENSMUST00000030939.8 ENSMUST00000030939.9 NADK_MOUSE NM_138671 P58058 Q3TCP7 uc008wdt.1 uc008wdt.2 uc008wdt.3 uc008wdt.4 Reaction=ATP + NAD(+) = ADP + H(+) + NADP(+); Xref=Rhea:RHEA:18629, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57540, ChEBI:CHEBI:58349, ChEBI:CHEBI:456216; EC=2.7.1.23; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Belongs to the NAD kinase family. nucleotide binding NAD+ kinase activity ATP binding cytosol NADP biosynthetic process kinase activity phosphorylation transferase activity NAD metabolic process positive regulation of insulin secretion involved in cellular response to glucose stimulus metal ion binding uc008wdt.1 uc008wdt.2 uc008wdt.3 uc008wdt.4 
ENSMUST00000030942.13 Mrpl20 ENSMUST00000030942.13 mitochondrial ribosomal protein L20 (from RefSeq NM_025570.3) ENSMUST00000030942.1 ENSMUST00000030942.10 ENSMUST00000030942.11 ENSMUST00000030942.12 ENSMUST00000030942.2 ENSMUST00000030942.3 ENSMUST00000030942.4 ENSMUST00000030942.5 ENSMUST00000030942.6 ENSMUST00000030942.7 ENSMUST00000030942.8 ENSMUST00000030942.9 NM_025570 Q9CQL4 Q9D5L3 RM20_MOUSE uc008weu.1 uc008weu.2 uc008weu.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity). Interacts with OXA1L (By similarity). Mitochondrion Belongs to the bacterial ribosomal protein bL20 family. ribosomal large subunit assembly structural constituent of ribosome mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit ribosome translation rRNA binding uc008weu.1 uc008weu.2 uc008weu.3 
ENSMUST00000030944.11 Ccnl2 ENSMUST00000030944.11 cyclin L2, transcript variant 1 (from RefSeq NM_207678.3) A2AD95 A2RSY2 Ania6b CCNL2_MOUSE ENSMUST00000030944.1 ENSMUST00000030944.10 ENSMUST00000030944.2 ENSMUST00000030944.3 ENSMUST00000030944.4 ENSMUST00000030944.5 ENSMUST00000030944.6 ENSMUST00000030944.7 ENSMUST00000030944.8 ENSMUST00000030944.9 MNCb-5160 NM_207678 Q5XK66 Q60995 Q8C136 Q8CIJ8 Q99L73 Q9JJA7 Q9QXH5 uc008wew.1 uc008wew.2 Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Interacts with CDK11A, CDK11B, CDK12, CDK13 and POLR2A, the hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II. May form a ternary complex with CDK11B and casein kinase II (CKII). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 and SRSF7/SLU7. Nucleus speckle Nucleus, nucleoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9JJA7-1; Sequence=Displayed; Name=2; IsoId=Q9JJA7-2; Sequence=VSP_016134, VSP_016135; Name=3; IsoId=Q9JJA7-3; Sequence=VSP_016133; Widely expressed (at protein level). Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity). [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the cyclin family. Cyclin L subfamily. Sequence=AAC52504.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAC52504.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; regulation of cyclin-dependent protein serine/threonine kinase activity protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter cyclin-dependent protein serine/threonine kinase regulator activity nuclear speck intracellular membrane-bounded organelle uc008wew.1 uc008wew.2 
ENSMUST00000030947.4 Mxra8 ENSMUST00000030947.4 matrix-remodelling associated 8 (from RefSeq NM_024263.4) Asp3 Dicam ENSMUST00000030947.1 ENSMUST00000030947.2 ENSMUST00000030947.3 MXRA8_MOUSE Mxra8 NM_024263 Q76M97 Q920S7 Q9DBV4 uc012dqy.1 uc012dqy.2 uc012dqy.3 Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220). Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220). Stimulates formation of primary cilia in chondrocytes (PubMed:29702220). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity). May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461). Homodimer in cis (PubMed:18366072). Does not appear to form trans-homodimers (PubMed:18366072). Interacts with ITGB3; the interaction inhibits ITGAV:ITGB3 heterodimer formation (PubMed:22492581). Cell membrane ingle-pass type I membrane protein Cell junction, tight junction Cytoplasm ll projection, cilium membrane Nucleus Note=Primarily localizes to the cell membrane (PubMed:18366072). Detected in the cilium of primary chondrocytes (PubMed:29702220). Highly expressed at areas of cell-cell contact and may localize to tight junctions (PubMed:18366072). Also found in the nucleus where it is detected in the soluble (as opposed to chromatin-bound) fraction (PubMed:18366072). Widely expressed (at protein level) (PubMed:18366072). Highly expressed in brain where it localizes to the glia limitans, which is formed by the endfeet of astrocytes surrounding capillaries, and beneath the pia mater (at protein level) (PubMed:14603461). In lung, detected in epithelial cells of the bronchus (at protein level). Expressed in intercalated disks in the heart (at protein level) (PubMed:18366072). Detected in pancreatic alpha-cells in the islet of Langerhans (at protein level) (PubMed:18366072). In kidney, found in the brush border of the proximal convoluted tubule (at protein level) (PubMed:18366072). Expressed in the epithelium of the small intestine (at protein level) (PubMed:18366072). Weakly expressed in liver (at protein level) (PubMed:18366072). Detected in myeloid cells (PubMed:22492581). At embryonic stage 15.5 dpc, expressed in the growth plate of long bones where it is mostly found in chondrocytes in the resting and proliferative zones (at protein level) (PubMed:29702220). Expression gradually increases in differentiating osteoclasts, but then decreases during the late stages of differentiation (PubMed:22492581). Disruption of the blood-brain barrier by cold injury results in a drastic reduction in expression (PubMed:14603461). Up-regulated in primary chondrocytes in response to BMP2 and PTHLH/PTHrP (PubMed:29702220). RGD motif 2 (but not RGD motif 1) is involved in integrin ITGAV:ITGB3 binding. molecular_function nucleus cytoplasm plasma membrane bicellular tight junction cell adhesion biological_process cell surface membrane integral component of membrane cell junction cell projection ciliary membrane establishment of glial blood-brain barrier uc012dqy.1 uc012dqy.2 uc012dqy.3 
ENSMUST00000030948.16 Dvl1 ENSMUST00000030948.16 dishevelled segment polarity protein 1, transcript variant 1 (from RefSeq NM_010091.5) DVL1_MOUSE Dvl ENSMUST00000030948.1 ENSMUST00000030948.10 ENSMUST00000030948.11 ENSMUST00000030948.12 ENSMUST00000030948.13 ENSMUST00000030948.14 ENSMUST00000030948.15 ENSMUST00000030948.2 ENSMUST00000030948.3 ENSMUST00000030948.4 ENSMUST00000030948.5 ENSMUST00000030948.6 ENSMUST00000030948.7 ENSMUST00000030948.8 ENSMUST00000030948.9 NM_010091 P51141 Q3U2D3 Q60868 uc008wfc.1 uc008wfc.2 uc008wfc.3 uc008wfc.4 The protein encoded by this gene is a member of the Dishevelled family of proteins. These proteins have an N-terminal Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a central PDZ domain, and a C-terminal domain of approximately 200 amino acids. They regulate both canonical and non-canonical Wnt signaling as well as planar cell polarity pathways. Mice deficient for this gene are viable and fertile but display reduced social interaction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U10115.1, AK155349.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Interacts with CXXC4 (By similarity). Interacts (via PDZ domain) with TMEM88 (By similarity). Interacts with BRD7 and INVS. Interacts (via PDZ domain) with VANGL1 and VANGL2 (via C-terminus). Interacts (via PDZ domain) with NXN. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Interacts with CYLD. Interacts (via PDZ domain) with RYK. Self- associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site. Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering. Interacts with DCDC2. Interacts with FOXK2 (By similarity). Interacts with PKD1 (via extracellular domain) (PubMed:27214281). Interacts (via PDZ domain) with CCDC88C/DAPLE; competes with CCDC88C for binding to frizzled receptor FZD7 and dissociates from CCDC88C following initiation of non- canonical Wnt signaling when CCDC88C displaces DVL1 from ligand- activated FZD7 (By similarity). P51141; Q8R4A3: Dact1; NbExp=4; IntAct=EBI-1538407, EBI-3870250; P51141; Q08639: Tfdp1; NbExp=3; IntAct=EBI-1538407, EBI-1216575; P51141; Q9D0N8: Tmem88; NbExp=2; IntAct=EBI-1538407, EBI-6136970; P51141; Q80Z96: Vangl1; NbExp=2; IntAct=EBI-1538407, EBI-1750708; P51141; Q91ZD4: Vangl2; NbExp=2; IntAct=EBI-1538407, EBI-1750744; P51141; Q8AVJ9: fzd7-b; Xeno; NbExp=3; IntAct=EBI-1538407, EBI-3870271; Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytosol Cytoplasmic vesicle Note=Localizes at the cell membrane upon interaction with frizzled family members. High levels are seen in the brain, testis and kidney, lower levels in the ovary, breast, muscle, liver and small intestine, and very low levels are seen in the spleen and thymus. A moderate level expression is seen in the heart. Is expressed throughout the embryonic central nervous system from presomite stages and in neuron-rich areas of the brain throughout postnatal development, as well as in many other tissues. The DIX domain promotes homooligomerization. The DEP domain mediates interaction with the cell membrane. Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination (By similarity). Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Mice display abnormalities in social behavior and sensorimotor gating. Belongs to the DSH family. regulation of neurotransmitter levels regulation of protein phosphorylation negative regulation of protein phosphorylation positive regulation of protein phosphorylation frizzled binding protein binding cytoplasm cytosol microtubule plasma membrane transcription from RNA polymerase II promoter negative regulation of protein kinase activity neurotransmitter secretion multicellular organism development axonogenesis axon guidance neuromuscular junction development beta-catenin binding positive regulation of neuron projection development postsynaptic density microtubule cytoskeleton membrane Wnt signaling pathway lateral plasma membrane enzyme binding protein kinase binding neural tube development convergent extension involved in neural plate elongation clathrin-coated vesicle axon dendrite growth cone cytoplasmic microtubule organization cytoplasmic vesicle negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein localization to nucleus social behavior protein localization to microtubule intracellular signal transduction identical protein binding neuron projection neuronal cell body receptor clustering dendritic spine synapse positive regulation of transcription, DNA-templated Rac GTPase binding collateral sprouting axon extension dendrite morphogenesis synapse organization protein stabilization convergent extension involved in organogenesis canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway prepulse inhibition dendritic spine morphogenesis skeletal muscle acetylcholine-gated channel clustering cochlea morphogenesis planar cell polarity pathway involved in neural tube closure presynapse glutamatergic synapse presynapse assembly regulation of cellular protein localization Wnt signalosome regulation of synaptic vesicle exocytosis positive regulation of excitatory postsynaptic potential uc008wfc.1 uc008wfc.2 uc008wfc.3 uc008wfc.4 
ENSMUST00000030949.4 Tas1r3 ENSMUST00000030949.4 taste receptor, type 1, member 3 (from RefSeq NM_031872.2) A2ADA0 ENSMUST00000030949.1 ENSMUST00000030949.2 ENSMUST00000030949.3 NM_031872 Q91VA4 Q923K0 Q925A4 Q925D8 Q925D9 Sac T1r3 TS1R3_MOUSE Tr3 uc008wff.1 uc008wff.2 uc008wff.3 uc008wff.4 Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. Forms homodimers or heterodimers with TAS1R1 and TAS1R2. Cell membrane; Multi-pass membrane protein. Expressed in circumvallate, foliate and fungiform taste papillae as well as in taste buds on the palate. Also expressed in testis. Not expressed in brain, heart, kidney, liver or spleen. The topographic distribution in various taste papillae is different from those of other T1R members. The Thr-60 variant is predicted to introduce a novel N-linked glycosylation site at Asn-58. The addition of even a short carbohydrate group at Asn-58 is predicted to disrupt one of the contact surfaces required for stability of a dimer. Therefore a Thr-60 variant N- glycosylated at Asn-58 is predicted to be precluded from forming homodimers or heterodimers. Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily. detection of chemical stimulus involved in sensory perception of sweet taste G-protein coupled receptor activity protein binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway taste receptor activity membrane integral component of membrane sweet taste receptor activity signaling receptor activity response to stimulus sensory perception of taste sensory perception of sweet taste sensory perception of umami taste sweet taste receptor complex uc008wff.1 uc008wff.2 uc008wff.3 uc008wff.4 
ENSMUST00000030950.8 Cptp ENSMUST00000030950.8 ceramide-1-phosphate transfer protein (from RefSeq NM_024472.4) A2ADA2 CPTP_MOUSE Cptp ENSMUST00000030950.1 ENSMUST00000030950.2 ENSMUST00000030950.3 ENSMUST00000030950.4 ENSMUST00000030950.5 ENSMUST00000030950.6 ENSMUST00000030950.7 Gltpd1 NM_024472 Q8BS40 Q99LU9 uc008wfg.1 uc008wfg.2 Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1- phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (By similarity). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed:29164996). Reaction=N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) = N- (hexadecanoyl)-sphing-4-enine-1-phosphate(out); Xref=Rhea:RHEA:45680, ChEBI:CHEBI:72963; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45681; Evidence=; Reaction=N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) = N-(9Z- octadecenoyl)-sphing-4-enine-1-phosphate(out); Xref=Rhea:RHEA:45688, ChEBI:CHEBI:85378; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45689; Evidence=; Cytoplasm, cytosol Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Endosome membrane ; Peripheral membrane protein Nucleus outer membrane ; Peripheral membrane protein Belongs to the GLTP family. phospholipid binding nucleus nuclear outer membrane cytoplasm endosome Golgi apparatus cytosol plasma membrane lipid transport lipid binding endosome membrane negative regulation of autophagy membrane ceramide transport negative regulation of interleukin-1 beta secretion negative regulation of NLRP3 inflammasome complex assembly ceramide 1-phosphate binding ceramide 1-phosphate transporter activity ceramide 1-phosphate transport uc008wfg.1 uc008wfg.2 
ENSMUST00000030952.6 Tnfrsf4 ENSMUST00000030952.6 tumor necrosis factor receptor superfamily, member 4 (from RefSeq NM_011659.2) B1ASL3 B1ASL3_MOUSE ENSMUST00000030952.1 ENSMUST00000030952.2 ENSMUST00000030952.3 ENSMUST00000030952.4 ENSMUST00000030952.5 NM_011659 Tnfrsf4 uc008wfu.1 uc008wfu.2 uc008wfu.3 Lacks conserved residue(s) required for the propagation of feature annotation. cell surface membrane integral component of membrane T cell proliferation uc008wfu.1 uc008wfu.2 uc008wfu.3 
ENSMUST00000030964.6 Cd38 ENSMUST00000030964.6 CD38 antigen (from RefSeq NM_007646.6) Cd38 ENSMUST00000030964.1 ENSMUST00000030964.2 ENSMUST00000030964.3 ENSMUST00000030964.4 ENSMUST00000030964.5 NM_007646 Q4FJL8 Q4FJL8_MOUSE uc008xic.1 uc008xic.2 uc008xic.3 uc008xic.4 uc008xic.5 This gene encodes a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Knockout mice deficient for this gene display altered humoral immune responses. In addition, knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK038439.1, AK153215.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence=; Homodimer. Membrane ; Single- pass type II membrane protein Belongs to the ADP-ribosyl cyclase family. response to hypoxia NAD+ nucleosidase activity nucleus plasma membrane positive regulation of cytosolic calcium ion concentration female pregnancy positive regulation of cell proliferation response to hormone negative regulation of neuron projection development artery smooth muscle contraction membrane integral component of membrane basolateral plasma membrane positive regulation of cell growth secretory granule membrane positive regulation of B cell proliferation positive regulation of insulin secretion response to estradiol response to retinoic acid response to progesterone response to hydroperoxide response to cytokine response to drug negative regulation of apoptotic process intracellular membrane-bounded organelle negative regulation of bone resorption negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of vasoconstriction NAD(P)+ nucleosidase activity B cell receptor signaling pathway long term synaptic depression response to interleukin-1 uc008xic.1 uc008xic.2 uc008xic.3 uc008xic.4 uc008xic.5 
ENSMUST00000030971.7 Adgra3 ENSMUST00000030971.7 adhesion G protein-coupled receptor A3 (from RefSeq NM_133911.1) AGRA3_MOUSE E9QK56 ENSMUST00000030971.1 ENSMUST00000030971.2 ENSMUST00000030971.3 ENSMUST00000030971.4 ENSMUST00000030971.5 ENSMUST00000030971.6 Gpr125 NM_133911 Q6PE67 Q7TT36 Q8VE71 uc008xjz.1 uc008xjz.2 uc008xjz.3 uc008xjz.4 Orphan receptor that may have a role in planar cell polarity pathway. Interacts (via PDZ-binding motif) with DLG1. Membrane ; Multi- pass membrane protein Expressed by spermatogonial progenitor cells located within the outer cell layer of the seminiferous tubule and by multipotent adult spermatogonial-derived stem cells. Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRA3 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Sequence=AAH52391.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; transmembrane signaling receptor activity G-protein coupled receptor activity signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway external side of plasma membrane membrane integral component of membrane uc008xjz.1 uc008xjz.2 uc008xjz.3 uc008xjz.4 
ENSMUST00000030980.12 Trmt44 ENSMUST00000030980.12 tRNA methyltransferase 44 (from RefSeq NM_030208.3) A7MCV4 ENSMUST00000030980.1 ENSMUST00000030980.10 ENSMUST00000030980.11 ENSMUST00000030980.2 ENSMUST00000030980.3 ENSMUST00000030980.4 ENSMUST00000030980.5 ENSMUST00000030980.6 ENSMUST00000030980.7 ENSMUST00000030980.8 ENSMUST00000030980.9 Mettl19 NM_030208 Q3V1K3 Q9D2Q2 TRM44_MOUSE uc008xdu.1 uc008xdu.2 uc008xdu.3 uc008xdu.4 Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase. Reaction=S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O- methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43100, Rhea:RHEA-COMP:10339, Rhea:RHEA-COMP:10340, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65315, ChEBI:CHEBI:74478; EC=2.1.1.211; Cytoplasm Belongs to the TRM44 family. cellular_component cytoplasm tRNA processing methyltransferase activity tRNA (uracil) methyltransferase activity transferase activity tRNA methylation methylation metal ion binding uc008xdu.1 uc008xdu.2 uc008xdu.3 uc008xdu.4 
ENSMUST00000030984.14 Rgs12 ENSMUST00000030984.14 regulator of G-protein signaling 12, transcript variant 1 (from RefSeq NM_173402.3) E9PXX2 ENSMUST00000030984.1 ENSMUST00000030984.10 ENSMUST00000030984.11 ENSMUST00000030984.12 ENSMUST00000030984.13 ENSMUST00000030984.2 ENSMUST00000030984.3 ENSMUST00000030984.4 ENSMUST00000030984.5 ENSMUST00000030984.6 ENSMUST00000030984.7 ENSMUST00000030984.8 ENSMUST00000030984.9 NM_173402 Q8CGE9 RGS12_MOUSE uc008xdg.1 uc008xdg.2 uc008xdg.3 uc008xdg.4 uc008xdg.5 Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent. Q8CGE9; Q63932: Map2k2; NbExp=3; IntAct=EBI-7340552, EBI-397724; Q8CGE9; P15056: BRAF; Xeno; NbExp=2; IntAct=EBI-7340552, EBI-365980; Nucleus Cytoplasm Cell projection, dendrite Synapse Expressed in brain. Expressed in germinal vesicle oocyte, metaphase II oocyte and blastocyst (at protein level). Expressed in oocyte. The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3. G-protein alpha-subunit binding GTPase activator activity protein binding nucleus nucleolus cytoplasm cytosol plasma membrane signal transduction cell junction dendrite GTPase regulator activity macromolecular complex termination of G-protein coupled receptor signaling pathway cell projection neuronal cell body positive regulation of GTPase activity synapse regulation of catalytic activity apical dendrite uc008xdg.1 uc008xdg.2 uc008xdg.3 uc008xdg.4 uc008xdg.5 
ENSMUST00000030985.10 Hgfac ENSMUST00000030985.10 hepatocyte growth factor activator (from RefSeq NM_019447.3) ENSMUST00000030985.1 ENSMUST00000030985.2 ENSMUST00000030985.3 ENSMUST00000030985.4 ENSMUST00000030985.5 ENSMUST00000030985.6 ENSMUST00000030985.7 ENSMUST00000030985.8 ENSMUST00000030985.9 HGFA_MOUSE NM_019447 Q9JKV4 Q9R098 uc008xdj.1 uc008xdj.2 uc008xdj.3 uc008xdj.4 uc008xdj.5 This gene encodes a serine protease enzyme that proteolytically activates hepatocyte growth factor (HGF) and plays a vital role in the regulation of HGF activity in the regeneration and repair of various tissues. The encoded protein is an inactive zymogen that is proteolytically activated to generate a heterodimeric enzyme consisting of a short chain and a long chain linked by a disulfide bridge. Mice lacking the encoded protein display an impairment in mucosal regeneration after injury. [provided by RefSeq, Jul 2015]. ##Evidence-Data-START## Transcript exon combination :: AK007987.1, AK169989.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. Heterodimer of a short chain and a long chain linked by a disulfide bond. Secreted Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. Belongs to the peptidase S1 family. serine-type endopeptidase activity extracellular region extracellular space cytoplasm rough endoplasmic reticulum proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc008xdj.1 uc008xdj.2 uc008xdj.3 uc008xdj.4 uc008xdj.5 
ENSMUST00000030986.15 Lrpap1 ENSMUST00000030986.15 low density lipoprotein receptor-related protein associated protein 1 (from RefSeq NM_013587.3) ENSMUST00000030986.1 ENSMUST00000030986.10 ENSMUST00000030986.11 ENSMUST00000030986.12 ENSMUST00000030986.13 ENSMUST00000030986.14 ENSMUST00000030986.2 ENSMUST00000030986.3 ENSMUST00000030986.4 ENSMUST00000030986.5 ENSMUST00000030986.6 ENSMUST00000030986.7 ENSMUST00000030986.8 ENSMUST00000030986.9 Lrpap1 NM_013587 Q52KI7 Q52KI7_MOUSE uc008xdo.1 uc008xdo.2 uc008xdo.3 negative regulation of receptor internalization cytoplasm endosome endoplasmic reticulum rough endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cis-Golgi network plasma membrane heparin binding negative regulation of very-low-density lipoprotein particle clearance vesicle negative regulation of protein binding lipase binding receptor antagonist activity rough endoplasmic reticulum lumen regulation of receptor-mediated endocytosis low-density lipoprotein particle receptor binding negative regulation of cell death very-low-density lipoprotein particle receptor binding negative regulation of beta-amyloid clearance negative regulation of receptor activity uc008xdo.1 uc008xdo.2 uc008xdo.3 
ENSMUST00000030993.8 Nelfa ENSMUST00000030993.8 negative elongation factor complex member A, Whsc2, transcript variant 1 (from RefSeq NM_011914.4) ENSMUST00000030993.1 ENSMUST00000030993.2 ENSMUST00000030993.3 ENSMUST00000030993.4 ENSMUST00000030993.5 ENSMUST00000030993.6 ENSMUST00000030993.7 NELFA_MOUSE NM_011914 Q8BG30 Q8BVE4 Q8VEI7 Q9CSJ9 Q9Z1V9 Whsc2 Whsc2h uc008xbn.1 uc008xbn.2 uc008xbn.3 uc008xbn.4 Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). The NELF complex is composed of NELFA, NELFB, NELFCD and NELFE; NELFA and NELFCD form a stable subcomplex that binds to the N- terminus of NELFB (By similarity). In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure- dependent manner (By similarity). Interacts with the RNA polymerase II complex when it is not phosphorylated by P-TEFb (By similarity). Interacts with NELFB (PubMed:26010750). Nucleus Ubiquitous. Expressed in brain, heart, spleen, lung, liver, muscle, kidney and testis. Already expressed in 7 dpc embryos. The HDAg-like domain is essential for transcriptional repression, and mediates the interaction with the RNA polymerase II complex. Belongs to the NELF-A family. Sequence=BAC37379.1; Type=Erroneous initiation; Evidence=; chromatin binding protein binding nucleus nucleoplasm cytosol nuclear body NELF complex negative regulation of transcription elongation from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter positive regulation of histone H3-K4 methylation uc008xbn.1 uc008xbn.2 uc008xbn.3 uc008xbn.4 
ENSMUST00000031002.10 Man2b2 ENSMUST00000031002.10 mannosidase 2, alpha B2, transcript variant 1 (from RefSeq NM_008550.3) ENSMUST00000031002.1 ENSMUST00000031002.2 ENSMUST00000031002.3 ENSMUST00000031002.4 ENSMUST00000031002.5 ENSMUST00000031002.6 ENSMUST00000031002.7 ENSMUST00000031002.8 ENSMUST00000031002.9 Kiaa0935 MA2B2_MOUSE NM_008550 O54782 Q69ZV1 Q8BH85 Q9DBK2 uc008xfb.1 uc008xfb.2 uc008xfb.3 uc008xfb.4 Plays an important role in the early step of spermatogenesis. Reaction=Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.; EC=3.2.1.24; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted. Mainly expressed in the narrow region between the caput and corpus epididymis. Specifically expressed in type A spermatogonia at stages IX-XI of spermatogenesis. Detected there until the cell developed into type B spermatogonia. Belongs to the glycosyl hydrolase 38 family. catalytic activity alpha-mannosidase activity extracellular region extracellular space lysosome vacuolar membrane carbohydrate metabolic process mannose metabolic process protein deglycosylation metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds carbohydrate binding metal ion binding uc008xfb.1 uc008xfb.2 uc008xfb.3 uc008xfb.4 
ENSMUST00000031003.11 Ppp2r2c ENSMUST00000031003.11 protein phosphatase 2, regulatory subunit B, gamma, transcript variant 1 (from RefSeq NM_172994.4) 2ABG_MOUSE ENSMUST00000031003.1 ENSMUST00000031003.10 ENSMUST00000031003.2 ENSMUST00000031003.3 ENSMUST00000031003.4 ENSMUST00000031003.5 ENSMUST00000031003.6 ENSMUST00000031003.7 ENSMUST00000031003.8 ENSMUST00000031003.9 NM_172994 Q8BG02 uc008xfe.1 uc008xfe.2 uc008xfe.3 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with IER5 (By similarity). Belongs to the phosphatase 2A regulatory subunit B family. protein phosphatase type 2A complex mitotic cell cycle cytosol protein phosphatase regulator activity regulation of phosphoprotein phosphatase activity peptidyl-serine dephosphorylation protein serine/threonine phosphatase activity uc008xfe.1 uc008xfe.2 uc008xfe.3 
ENSMUST00000031004.11 Crmp1 ENSMUST00000031004.11 collapsin response mediator protein 1, transcript variant 2 (from RefSeq NM_007765.4) DPYL1_MOUSE Dpysl1 ENSMUST00000031004.1 ENSMUST00000031004.10 ENSMUST00000031004.2 ENSMUST00000031004.3 ENSMUST00000031004.4 ENSMUST00000031004.5 ENSMUST00000031004.6 ENSMUST00000031004.7 ENSMUST00000031004.8 ENSMUST00000031004.9 NM_007765 O08554 O35097 P97427 Ulip3 uc008xfm.1 uc008xfm.2 uc008xfm.3 uc008xfm.4 This gene encodes a protein that is part of the collapsin response mediator protein family. The family is comprised of five, homologous cytosolic phosphoproteins that are expressed in developing and adult nervous tissue and mediate signaling to transduce responses to extracellular cues. This protein is a Semaphorin 3A signaling molecule that regulates collapse of the growth cone. The growth cone mediates axonal pathfinding in neurons. This protein is reported to represent a new class of microtubule-associated proteins. In humans this protein is reported to inhibit cancer cell invasion. In mouse deficiency of this gene may be associated with impaired spatial memory performance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863, PubMed:14685275). Plays a role in axon guidance (PubMed:14685275). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (By similarity). May participate in cytokinesis (By similarity). Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5 (PubMed:10956643, PubMed:14685275). Interacts with PLXNA1 (PubMed:14685275). Interacts with FLNA (via calponin-homology (CH) domain 1 and filamin repeat 24); the interaction alters FLNA ternary structure and thus promotes FLNA dissociation from F-actin (By similarity). Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cell projection, growth cone Cytoplasm, cytoskeleton Perikaryon Note=Associated with centrosomes and the mitotic spindle during metaphase (By similarity). Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone (PubMed:25358863). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (PubMed:25358863). Expressed in DRG neurons of 12 dpc embryos. Phosphorylation at Ser-522 enhances CRMP1-mediated alteration of FLNA ternary structure and FLNA dissociation from F-actin. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure. microtubule cytoskeleton organization nucleus cytoplasm centrosome microtubule organizing center spindle cytosol cytoskeleton nervous system development axon guidance negative regulation of neuron projection development actin cytoskeleton hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides dendrite growth cone midbody filamin binding identical protein binding neuronal cell body phosphoprotein binding semaphorin-plexin signaling pathway negative regulation of actin filament binding dihydropyrimidinase activity pyrimidine nucleobase catabolic process uc008xfm.1 uc008xfm.2 uc008xfm.3 uc008xfm.4 
ENSMUST00000031005.11 Evc ENSMUST00000031005.11 EvC ciliary complex subunit 1, transcript variant 1 (from RefSeq NM_021292.3) E9QPK2 ENSMUST00000031005.1 ENSMUST00000031005.10 ENSMUST00000031005.2 ENSMUST00000031005.3 ENSMUST00000031005.4 ENSMUST00000031005.5 ENSMUST00000031005.6 ENSMUST00000031005.7 ENSMUST00000031005.8 ENSMUST00000031005.9 EVC_MOUSE NM_021292 P57680 uc008xfo.1 uc008xfo.2 uc008xfo.3 uc008xfo.4 Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:17660199, PubMed:24582806). Involved in endochondral growth and skeletal development (PubMed:17660199). Component of the EvC complex composed of EFCAB7, IQCE, EVC2 and EVC; built from two subcomplexes, EVC2:EVC and EFCAB7:IQCE (PubMed:24582806). Interacts with EVC2 (PubMed:24582806, PubMed:21356043). Interacts with EFCAB7 (PubMed:24582806). Interacts with IQCE (PubMed:24582806). Cell membrane ; Single-pass membrane protein Cytoplasm, cytoskeleton, cilium basal body Cell projection, cilium Cell projection, cilium membrane te=EVC2 is required for the localization of EVC at the base of primary cilia (PubMed:21356043). The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner (PubMed:24582806). Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P57680-1; Sequence=Displayed; Name=Short; IsoId=P57680-2; Sequence=VSP_004247; Expressed in the developing skeleton and the orofacial region. Expression is general to all the cartilaginous components of the skeleton, including the chondrocranium, the vertebrae, the rib cage, and the axial skeleton by 15.5 dpc. endochondral bone growth protein binding cytoplasm cytoskeleton plasma membrane cilium smoothened signaling pathway membrane integral component of membrane ciliary basal body cell projection positive regulation of smoothened signaling pathway cartilage development ciliary membrane plasma membrane protein complex uc008xfo.1 uc008xfo.2 uc008xfo.3 uc008xfo.4 
ENSMUST00000031009.8 Nsg1 ENSMUST00000031009.8 neuron specific gene family member 1, transcript variant 2 (from RefSeq NM_010942.4) ENSMUST00000031009.1 ENSMUST00000031009.2 ENSMUST00000031009.3 ENSMUST00000031009.4 ENSMUST00000031009.5 ENSMUST00000031009.6 ENSMUST00000031009.7 NEEP21 NM_010942 NSG1_MOUSE Nsg1 O54717 Q3UF63 Q62092 Q922E5 uc008xga.1 uc008xga.2 uc008xga.3 Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway (PubMed:15187090, PubMed:12070131, PubMed:21084623, PubMed:16037816). Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (PubMed:16037816). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity). Forms a complex with GRIP1, GRIA2 and STX12 through direct interaction with GRIP1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Interacts with STX12 (PubMed:12070131). Interacts with APP; could regulate APP processing (PubMed:21084623). Interacts with FAM171A1 (By similarity). Membrane ; Single- pass type II membrane protein Golgi apparatus, trans-Golgi network membrane Endosome membrane Cell projection, dendrite Early endosome membrane Late endosome membrane Lysosome lumen Recycling endosome membrane Cytoplasmic vesicle membrane Golgi apparatus, Golgi stack membrane Endosome, multivesicular body membrane Endoplasmic reticulum membrane Note=Endocytosed from the cell surface, thus enters into early endosomes, trafficks to late endosomes and degradates in lysosomes (By similarity). Endoplasmic reticulum targeting is essential for apoptosis (By similarity). Found in both stationary and motile endosomes (PubMed:28874679). A previous study supports a type I membrane protein topology (PubMed:12070131). Pituitary and less in adrenal gland and testis. Expressed in the hippocampus throughout development. At P0, highly and broadly expressed throughout the cortical plate, but is down-regulated overall at P8 and P14, but remains relatively enriched in layer V. At P0 is expressed ubiquitously in the developing cerebellum namely Purkinje neurons as well as granule neurons. However, it becomes restricted to Purkinje cells by P8. This exclusive expression in Purkinje cells is maintained throughout adulthood. At 17.5 dpc, highly expressed in the cortical plate and in the subplate (SP). Belongs to the NSG family. receptor recycling positive regulation of receptor recycling receptor binding protein binding lysosome endosome early endosome late endosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus apoptotic process dopamine receptor signaling pathway endosome membrane membrane integral component of membrane endosomal transport lateral plasma membrane dendrite cytoplasmic vesicle membrane cytoplasmic vesicle early endosome membrane late endosome membrane clathrin light chain binding Golgi cisterna membrane multivesicular body membrane trans-Golgi network membrane somatodendritic compartment amyloid precursor protein metabolic process cell projection lysosomal lumen postsynaptic membrane clathrin coat assembly recycling endosome membrane spontaneous synaptic transmission postsynaptic endosome neurotransmitter receptor transport, endosome to postsynaptic membrane glutamatergic synapse vesicle-mediated transport in synapse neurotransmitter receptor cycle postsynaptic neurotransmitter receptor cycle regulation of long-term synaptic potentiation uc008xga.1 uc008xga.2 uc008xga.3 
ENSMUST00000031011.12 Rab28 ENSMUST00000031011.12 RAB28, member RAS oncogene family, transcript variant 5 (from RefSeq NR_132325.1) ENSMUST00000031011.1 ENSMUST00000031011.10 ENSMUST00000031011.11 ENSMUST00000031011.2 ENSMUST00000031011.3 ENSMUST00000031011.4 ENSMUST00000031011.5 ENSMUST00000031011.6 ENSMUST00000031011.7 ENSMUST00000031011.8 ENSMUST00000031011.9 NR_132325 Q99KL7 RAB28_MOUSE uc008xha.1 uc008xha.2 uc008xha.3 uc008xha.4 Cell membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasm, cytoskeleton, cilium basal body. Note=Expressed in the basal body and ciliary rootlet of the photoreceptors. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity GTP binding cytoplasm cytoskeleton plasma membrane intracellular protein transport membrane GDP binding Rab protein signal transduction ciliary rootlet ciliary basal body cell projection toxin transport uc008xha.1 uc008xha.2 uc008xha.3 uc008xha.4 
ENSMUST00000031017.11 Fosl2 ENSMUST00000031017.11 fos-like antigen 2 (from RefSeq NM_008037.4) ENSMUST00000031017.1 ENSMUST00000031017.10 ENSMUST00000031017.2 ENSMUST00000031017.3 ENSMUST00000031017.4 ENSMUST00000031017.5 ENSMUST00000031017.6 ENSMUST00000031017.7 ENSMUST00000031017.8 ENSMUST00000031017.9 FOSL2_MOUSE Fra-2 Fra2 NM_008037 P47930 Q3UKX7 Q8C231 uc008wzi.1 uc008wzi.2 uc008wzi.3 uc008wzi.4 uc008wzi.5 Controls osteoclast survival and size (PubMed:18548006). As a dimer with JUN, activates LIF transcription (PubMed:18548006). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). Heterodimer; with JUN (PubMed:18548006). Interacts with the BAF multiprotein chromatin-remodeling complex subunits SMARCB1 and SMARCD1 (PubMed:29272704). Interacts with ARID1A and JUN (PubMed:29272704). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P47930-1; Sequence=Displayed; Name=2; IsoId=P47930-2; Sequence=VSP_042084; Mutant pups die within a week after birth. They exhibit severe osteopenia as early as 18.5 dpc, with a 50% decrease in mineralized bone. Osteoblast numbers are not altered. The number, the relative surface covered by osteoclasts and the mean osteoclast surface are increased 3-fold, 5-fold and 2-fold, respectively. Bone resorption activity is increased. This phenotype is due to hypoxia in long bones resulting from placental defects. Belongs to the bZIP family. Fos subfamily. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding response to hypoxia keratinocyte development DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter response to estradiol sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation uc008wzi.1 uc008wzi.2 uc008wzi.3 uc008wzi.4 uc008wzi.5 
ENSMUST00000031018.10 Rbks ENSMUST00000031018.10 ribokinase, transcript variant 7 (from RefSeq NR_184570.1) ENSMUST00000031018.1 ENSMUST00000031018.2 ENSMUST00000031018.3 ENSMUST00000031018.4 ENSMUST00000031018.5 ENSMUST00000031018.6 ENSMUST00000031018.7 ENSMUST00000031018.8 ENSMUST00000031018.9 NR_184570 Q8R1Q9 RBSK_MOUSE Rbks Rbsk uc008wyv.1 uc008wyv.2 uc008wyv.3 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. Reaction=ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+); Xref=Rhea:RHEA:13697, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:47013, ChEBI:CHEBI:78346, ChEBI:CHEBI:456216; EC=2.7.1.15; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. ; Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity. Competitively inhibited by phosphonoacetic acid, etidronate, 2-carboxethylphosphonic acid, N- (phosphonomethyl)glycine, N-(phosphonomethyl)iminodiacetic acid and clodronate (By similarity). Carbohydrate metabolism; D-ribose degradation; D-ribose 5- phosphate from beta-D-ribopyranose: step 2/2. Homodimer. Cytoplasm Nucleus Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily. nucleotide binding ribokinase activity ATP binding nucleus cytoplasm carbohydrate metabolic process D-ribose metabolic process kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor D-ribose catabolic process carbohydrate phosphorylation metal ion binding uc008wyv.1 uc008wyv.2 uc008wyv.3 
ENSMUST00000031020.5 Ccdc121 ENSMUST00000031020.5 coiled-coil domain containing 121 (from RefSeq NM_026296.4) 4930548H24Rik Ccdc121 ENSMUST00000031020.1 ENSMUST00000031020.2 ENSMUST00000031020.3 ENSMUST00000031020.4 NM_026296 Q9D496 Q9D496_MOUSE uc008wyh.1 uc008wyh.2 uc008wyh.3 molecular_function cellular_component biological_process uc008wyh.1 uc008wyh.2 uc008wyh.3 
ENSMUST00000031024.14 Mrpl33 ENSMUST00000031024.14 mitochondrial ribosomal protein L33 (from RefSeq NM_025796.3) ENSMUST00000031024.1 ENSMUST00000031024.10 ENSMUST00000031024.11 ENSMUST00000031024.12 ENSMUST00000031024.13 ENSMUST00000031024.2 ENSMUST00000031024.3 ENSMUST00000031024.4 ENSMUST00000031024.5 ENSMUST00000031024.6 ENSMUST00000031024.7 ENSMUST00000031024.8 ENSMUST00000031024.9 NM_025796 Q9CQP0 Q9D860 RM33_MOUSE uc008wyt.1 uc008wyt.2 uc008wyt.3 uc008wyt.4 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the bacterial ribosomal protein bL33 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation uc008wyt.1 uc008wyt.2 uc008wyt.3 uc008wyt.4 
ENSMUST00000031029.15 Snx17 ENSMUST00000031029.15 sorting nexin 17, transcript variant 1 (from RefSeq NM_153680.3) ENSMUST00000031029.1 ENSMUST00000031029.10 ENSMUST00000031029.11 ENSMUST00000031029.12 ENSMUST00000031029.13 ENSMUST00000031029.14 ENSMUST00000031029.2 ENSMUST00000031029.3 ENSMUST00000031029.4 ENSMUST00000031029.5 ENSMUST00000031029.6 ENSMUST00000031029.7 ENSMUST00000031029.8 ENSMUST00000031029.9 NM_153680 Q8BVL3 Q8R0N8 SNX17_MOUSE uc008wxm.1 uc008wxm.2 uc008wxm.3 Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:12169628, PubMed:16052210). Binds to NPxY sequences in the cytoplasmic tails of target cargos (By similarity). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (By similarity). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16052210, PubMed:18276590). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). Monomer (By similarity). Interacts with APP (via cytoplasmic YXNPXY motif) (PubMed:18276590). Interacts with KIF1B (PubMed:19967056). Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with KRIT1 (via N-terminus) (PubMed:12169628, PubMed:16052210). Interacts with HRAS. Interacts with ITGB1 and ITGB5 (via NPxY motif). Interacts with CCDC22, CCDC93, VPS26C and VPS35L; the interaction with VPS26C is direct and associates SNX17 with the retriever and CCC complexes (By similarity). Cytoplasm Early endosome Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Detected in brain neurons (at protein level). Broadly expressed, with highest levels in brain and placenta, and lowest levels in colon, intestine and liver. The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes. The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras- associating) is responsible for interaction with membrane-bound HRAS. Belongs to the sorting nexin family. cardiac septum development cytoplasm endosome early endosome Golgi apparatus cytosol intracellular protein transport receptor-mediated endocytosis signal transduction protein C-terminus binding lipid binding endosome membrane protein transport membrane cytoplasmic vesicle membrane cytoplasmic vesicle endocytic recycling macromolecular complex phosphatidylinositol binding aorta development intracellular membrane-bounded organelle low-density lipoprotein particle receptor binding coronary vasculature development retrograde transport, endosome to plasma membrane uc008wxm.1 uc008wxm.2 uc008wxm.3 
ENSMUST00000031032.11 Ppm1g ENSMUST00000031032.11 protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform (from RefSeq NM_008014.3) ENSMUST00000031032.1 ENSMUST00000031032.10 ENSMUST00000031032.2 ENSMUST00000031032.3 ENSMUST00000031032.4 ENSMUST00000031032.5 ENSMUST00000031032.6 ENSMUST00000031032.7 ENSMUST00000031032.8 ENSMUST00000031032.9 Fin13 NM_008014 PPM1G_MOUSE Ppm1c Q61074 uc008wxr.1 uc008wxr.2 uc008wxr.3 May be involved in regulation of cell cycle. Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit. ; Interacts with NOL3; may dephosphorylate NOL3. Nucleus Membrane ; Lipid-anchor Highly expressed in testis. Low level of expression in kidney. Also expressed in a number of tissues undergoing proliferation including embryo, uterus at pregnancy, placenta, and ovaries. By FGF-4 and serum. Belongs to the PP2C family. catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity protein binding nucleus nucleoplasm protein dephosphorylation cell cycle cell cycle arrest membrane hydrolase activity peptidyl-threonine dephosphorylation cation binding metal ion binding uc008wxr.1 uc008wxr.2 uc008wxr.3 
ENSMUST00000031037.14 Slc30a3 ENSMUST00000031037.14 solute carrier family 30 (zinc transporter), member 3, transcript variant 1 (from RefSeq NM_011773.4) ENSMUST00000031037.1 ENSMUST00000031037.10 ENSMUST00000031037.11 ENSMUST00000031037.12 ENSMUST00000031037.13 ENSMUST00000031037.2 ENSMUST00000031037.3 ENSMUST00000031037.4 ENSMUST00000031037.5 ENSMUST00000031037.6 ENSMUST00000031037.7 ENSMUST00000031037.8 ENSMUST00000031037.9 NM_011773 Q3TMQ7 Q3TMQ7_MOUSE Slc30a3 uc008wxa.1 uc008wxa.2 uc008wxa.3 uc008wxa.4 uc008wxa.5 Probable proton-coupled zinc ion antiporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain. Reaction=2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out); Xref=Rhea:RHEA:72627, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105; Evidence=; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Synapse, synaptosome Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. cytoplasm late endosome cation transport synaptic vesicle cation transmembrane transporter activity membrane integral component of membrane transmembrane transport regulation of sequestering of zinc ion cation transmembrane transport uc008wxa.1 uc008wxa.2 uc008wxa.3 uc008wxa.4 uc008wxa.5 
ENSMUST00000031038.11 Ociad1 ENSMUST00000031038.11 OCIA domain containing 1, transcript variant 1 (from RefSeq NM_023429.4) Asrij ENSMUST00000031038.1 ENSMUST00000031038.10 ENSMUST00000031038.2 ENSMUST00000031038.3 ENSMUST00000031038.4 ENSMUST00000031038.5 ENSMUST00000031038.6 ENSMUST00000031038.7 ENSMUST00000031038.8 ENSMUST00000031038.9 NM_023429 OCAD1_MOUSE Ociad1 Q3TEC2 Q3TJS3 Q7TNB3 Q922M2 Q9CRD0 uc008xsu.1 uc008xsu.2 uc008xsu.3 uc008xsu.4 Maintains stem cell potency (PubMed:23972987). Increases STAT3 phosphorylation and controls ERK phosphorylation (PubMed:23972987). May act as a scaffold, increasing STAT3 recruitment onto endosomes (PubMed:23972987). Interacts with STAT3. Endosome Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9CRD0-1; Sequence=Displayed; Name=2; IsoId=Q9CRD0-2; Sequence=VSP_027623; Name=3; IsoId=Q9CRD0-3; Sequence=VSP_027624, VSP_027625; Expressed at high levels in the brain and at lower levels in the heart, ovary, testis and kidney. Expression is strongest in embryonic stem cells and in the blood vessels. First detected at 6.5 dpc in the primitive streak region of the epiblast and extraembryonic vasculature. Expression in the 8.5 dpc yolk sac is seen within blood islands and the capillary plexus. As embryogenesis proceeds, expression becomes prominent in the blood islands and the primitive blood vessels of the yolk sac. By 8-8.5 dpc, a more generalized expression pattern is seen in the neural folds and caudally in the presomitic mesoderm and primitive streak regions. A definite increase in vascular expression is seen in the embryo by 9.5 dpc. Tissue-specific expression is initially seen from early 9.5 dpc in the anterior-most regions of the head, mainly in the optic vesicle and branchial arches. At 11.5 dpc and 13.5 dpc, strong expression is seen in the embryonic stem cells of the blood vessels, especially in the capillaries of the brain and in the hyaline vasculature of the eye. Weak expression is also seen in the lingual vessels and in the neural crest-derived regions of the jaw. A rapid increase in expression in the trunk is seen between 9.5 dpc and 10.5 dpc and by 13.5 dpc, expression is more localized. Expression is not detected in the embryonic heart at early 9.5 dpc and from 11.5 dpc onward, increasing expression is seen in the atrium, ventricle, and outflow tracts of the heart. Expression is down-regulated as differentiation proceeds in stem cells. The OCIA domain is necessary and sufficient for endosomal localization (PubMed:23972987). 'Asrij' stands for 'blood' in Sanskrit as this protein is strongly expressed in blood vessels. Belongs to the OCIAD1 family. Sequence=BAE39422.1; Type=Frameshift; Evidence=; protein binding mitochondrion endosome regulation of stem cell differentiation uc008xsu.1 uc008xsu.2 uc008xsu.3 uc008xsu.4 
ENSMUST00000031040.13 Cwh43 ENSMUST00000031040.13 cell wall biogenesis 43 C-terminal homolog, transcript variant 1 (from RefSeq NM_181323.3) ENSMUST00000031040.1 ENSMUST00000031040.10 ENSMUST00000031040.11 ENSMUST00000031040.12 ENSMUST00000031040.2 ENSMUST00000031040.3 ENSMUST00000031040.4 ENSMUST00000031040.5 ENSMUST00000031040.6 ENSMUST00000031040.7 ENSMUST00000031040.8 ENSMUST00000031040.9 NM_181323 PG2IP_MOUSE Pgap2ip Q8CBQ1 Q91YL7 uc008xsx.1 uc008xsx.2 uc008xsx.3 Involved in lipid remodeling during GPI-anchor maturation. Interacts with PGAP2/FRAG1. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91YL7-1; Sequence=Displayed; Name=2; IsoId=Q91YL7-2; Sequence=VSP_031684; Belongs to the PGAP2IP family. molecular_function endoplasmic reticulum GPI anchor biosynthetic process membrane integral component of membrane uc008xsx.1 uc008xsx.2 uc008xsx.3 
ENSMUST00000031045.10 Yipf7 ENSMUST00000031045.10 Yip1 domain family, member 7 (from RefSeq NM_023784.5) ENSMUST00000031045.1 ENSMUST00000031045.2 ENSMUST00000031045.3 ENSMUST00000031045.4 ENSMUST00000031045.5 ENSMUST00000031045.6 ENSMUST00000031045.7 ENSMUST00000031045.8 ENSMUST00000031045.9 NM_023784 Q9JIM5 YIPF7_MOUSE Yip1b uc008xqk.1 uc008xqk.2 uc008xqk.3 uc008xqk.4 Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus, cis-Golgi network membrane Golgi apparatus, trans-Golgi network membrane Specifically expressed in the heart. Belongs to the YIP1 family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus biological_process membrane integral component of membrane uc008xqk.1 uc008xqk.2 uc008xqk.3 uc008xqk.4 
ENSMUST00000031051.9 Cgref1 ENSMUST00000031051.9 cell growth regulator with EF hand domain 1, transcript variant 1 (from RefSeq NM_026770.2) Cgref1 E9QPK1 E9QPK1_MOUSE ENSMUST00000031051.1 ENSMUST00000031051.2 ENSMUST00000031051.3 ENSMUST00000031051.4 ENSMUST00000031051.5 ENSMUST00000031051.6 ENSMUST00000031051.7 ENSMUST00000031051.8 NM_026770 uc008wwo.1 uc008wwo.2 uc008wwo.3 uc008wwo.4 calcium ion binding uc008wwo.1 uc008wwo.2 uc008wwo.3 uc008wwo.4 
ENSMUST00000031053.15 Khk ENSMUST00000031053.15 ketohexokinase, transcript variant 4 (from RefSeq NM_001349066.1) E9Q1Q9 E9Q1Q9_MOUSE ENSMUST00000031053.1 ENSMUST00000031053.10 ENSMUST00000031053.11 ENSMUST00000031053.12 ENSMUST00000031053.13 ENSMUST00000031053.14 ENSMUST00000031053.2 ENSMUST00000031053.3 ENSMUST00000031053.4 ENSMUST00000031053.5 ENSMUST00000031053.6 ENSMUST00000031053.7 ENSMUST00000031053.8 ENSMUST00000031053.9 Khk NM_001349066 uc057btt.1 uc057btt.2 uc057btt.3 ketohexokinase activity cytoplasm fructose metabolic process response to sucrose response to glucose response to fructose response to zinc ion response to insulin carbohydrate phosphorylation uc057btt.1 uc057btt.2 uc057btt.3 
ENSMUST00000031055.8 Emilin1 ENSMUST00000031055.8 elastin microfibril interfacer 1 (from RefSeq NM_133918.2) EMIL1_MOUSE ENSMUST00000031055.1 ENSMUST00000031055.2 ENSMUST00000031055.3 ENSMUST00000031055.4 ENSMUST00000031055.5 ENSMUST00000031055.6 ENSMUST00000031055.7 NM_133918 Q99K41 uc008wwm.1 uc008wwm.2 uc008wwm.3 uc008wwm.4 May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity (By similarity). May have a function in placenta formation and initial organogenesis and a later role in interstitial connective tissue. Homotrimer associated through a moderately stable interaction of the C-terminal globular C1q domains, allowing the nucleation of the triple helix and then a further quaternary assembly to higher-order polymers via intermolecular disulfide bonds. Interacts with EMILIN2 (By similarity). Interacts with EFEMP2; this interaction promotes the incorporation of EFEMP2 into the extracellular matrix (PubMed:28717224). Q99K41; P07200: TGFB1; Xeno; NbExp=2; IntAct=EBI-906561, EBI-907660; Secreted, extracellular space, extracellular matrix Note=Found mainly at the interface between amorphous elastin and microfibrils. Detectable in morula and blastocyst. First expressed in ectoplacental cone in embryos of 6.5 days and in extraembryonic visceral endoderm at 7.5 days. Expressed also in the allantois. Expression in the ectoplacental cone-derived secondary trophoblast giant cells and spongiotrophoblast is strong up to 11.5 days and then declines. In the embryo, high levels are initially expressed in blood vessels, perineural mesenchyme and somites at 8.5 days. Later on, intense expression is identified in the mesenchymal component of organs anlage (ie lung and liver) and different mesenchymal condensations (ie limb bud and branchial arches). At late gestation expression is widely distributed in interstitial connective tissue and smooth muscle cell-rich tissues. aortic valve morphogenesis protein binding extracellular region collagen trimer extracellular space cell adhesion cell-matrix adhesion positive regulation of gene expression negative regulation of gene expression positive regulation of cell-substrate adhesion cell migration negative regulation of angiogenesis extracellular matrix constituent conferring elasticity extracellular matrix organization negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of vascular endothelial growth factor receptor signaling pathway extracellular matrix negative regulation of collagen biosynthetic process integrin alpha4-beta1 complex identical protein binding elastic fiber assembly negative regulation of cell activation negative regulation of pathway-restricted SMAD protein phosphorylation protein homotrimerization negative regulation of ERK1 and ERK2 cascade integrin binding involved in cell-matrix adhesion positive regulation of extracellular matrix assembly negative regulation of collagen fibril organization negative regulation of macrophage migration EMILIN complex uc008wwm.1 uc008wwm.2 uc008wwm.3 uc008wwm.4 
ENSMUST00000031058.15 Mapre3 ENSMUST00000031058.15 microtubule-associated protein, RP/EB family, member 3, transcript variant 1 (from RefSeq NM_133350.3) ENSMUST00000031058.1 ENSMUST00000031058.10 ENSMUST00000031058.11 ENSMUST00000031058.12 ENSMUST00000031058.13 ENSMUST00000031058.14 ENSMUST00000031058.2 ENSMUST00000031058.3 ENSMUST00000031058.4 ENSMUST00000031058.5 ENSMUST00000031058.6 ENSMUST00000031058.7 ENSMUST00000031058.8 ENSMUST00000031058.9 MARE3_MOUSE NM_133350 Q61167 Q6PER3 uc008wvz.1 uc008wvz.2 uc008wvz.3 Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non- centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (By similarity). Homodimer (By similarity). Heterodimer with MAPRE1 (By similarity). Binds monomeric and polymerized GTP-bound tubulin. Interacts with DCTN1 and SRCIN1 (By similarity). Binds to the C- terminal domain of APC (By similarity). Interacts (via C-terminus) with CLIP1 (By similarity). Interacts with SLAIN2 (By similarity). Interacts with SLAIN1 (PubMed:21646404). Interacts with APC2 (PubMed:17310996). Interacts with AKAP9 (By similarity). Interacts with PDE4DIP isoform 2/MMG8/SMYLE; this interaction is required for its recruitment to the Golgi apparatus (By similarity). Cytoplasm, cytoskeleton Note=Associated with the microtubule network. Detected at the plus end of microtubules. Composed of two functionally independent domains. The N- terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1. Belongs to the MAPRE family. protein binding cytoplasm microtubule organizing center cytoskeleton microtubule cytoplasmic microtubule cell cycle microtubule binding protein C-terminus binding microtubule cytoskeleton protein kinase binding midbody regulation of microtubule polymerization or depolymerization regulation of microtubule polymerization microtubule plus-end protein localization to microtubule identical protein binding positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of protein kinase activity positive regulation of transcription, DNA-templated perinuclear region of cytoplasm microtubule plus-end binding spindle assembly spindle midzone cell division positive regulation of microtubule plus-end binding protein localization to microtubule plus-end mitotic spindle astral microtubule end uc008wvz.1 uc008wvz.2 uc008wvz.3 
ENSMUST00000031061.12 Dhx15 ENSMUST00000031061.12 DEAH-box helicase 15, transcript variant 3 (from RefSeq NR_104311.1) Dhx15 ENSMUST00000031061.1 ENSMUST00000031061.10 ENSMUST00000031061.11 ENSMUST00000031061.2 ENSMUST00000031061.3 ENSMUST00000031061.4 ENSMUST00000031061.5 ENSMUST00000031061.6 ENSMUST00000031061.7 ENSMUST00000031061.8 ENSMUST00000031061.9 NR_104311 Q3UKJ6 Q3UKJ6_MOUSE uc008xkf.1 uc008xkf.2 uc008xkf.3 uc008xkf.4 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. nucleotide binding nucleic acid binding double-stranded RNA binding helicase activity ATP binding U12-type spliceosomal complex response to toxic substance nuclear speck hydrolase activity response to alkaloid U2-type post-mRNA release spliceosomal complex uc008xkf.1 uc008xkf.2 uc008xkf.3 uc008xkf.4 
ENSMUST00000031069.13 Sepsecs ENSMUST00000031069.13 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase, transcript variant 1 (from RefSeq NM_172490.4) D5Ertd135e ENSMUST00000031069.1 ENSMUST00000031069.10 ENSMUST00000031069.11 ENSMUST00000031069.12 ENSMUST00000031069.2 ENSMUST00000031069.3 ENSMUST00000031069.4 ENSMUST00000031069.5 ENSMUST00000031069.6 ENSMUST00000031069.7 ENSMUST00000031069.8 ENSMUST00000031069.9 NM_172490 Q6P6M7 Q8BZS6 SPCS_MOUSE uc008xko.1 uc008xko.2 uc008xko.3 Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. Reaction=H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L- selenocysteinyl-tRNA(Sec) + 2 phosphate; Xref=Rhea:RHEA:25041, Rhea:RHEA-COMP:9743, Rhea:RHEA-COMP:9947, ChEBI:CHEBI:15377, ChEBI:CHEBI:16144, ChEBI:CHEBI:43474, ChEBI:CHEBI:78551, ChEBI:CHEBI:78573; EC=2.9.1.2; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2. Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer (By similarity). Cytoplasm Belongs to the SepSecS family. tRNA binding selenocysteine incorporation RNA binding catalytic activity protein binding nucleus cytoplasm translation transferase activity transferase activity, transferring selenium-containing groups selenocysteinyl-tRNA(Sec) biosynthetic process uc008xko.1 uc008xko.2 uc008xko.3 
ENSMUST00000031072.14 Anapc4 ENSMUST00000031072.14 anaphase promoting complex subunit 4 (from RefSeq NM_024213.2) APC4_MOUSE D5Ertd249e ENSMUST00000031072.1 ENSMUST00000031072.10 ENSMUST00000031072.11 ENSMUST00000031072.12 ENSMUST00000031072.13 ENSMUST00000031072.2 ENSMUST00000031072.3 ENSMUST00000031072.4 ENSMUST00000031072.5 ENSMUST00000031072.6 ENSMUST00000031072.7 ENSMUST00000031072.8 ENSMUST00000031072.9 NM_024213 Q91W96 Q99LR5 Q9CZZ0 uc008xkw.1 uc008xkw.2 uc008xkw.3 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Protein modification; protein ubiquitination. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. In the context of the APC/C complex, directly interacts with UBE2S. Interacts with FBXO43. Nucleus Belongs to the APC4 family. Sequence=BAB27965.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleus anaphase-promoting complex cell cycle protein ubiquitination protein phosphatase binding regulation of mitotic metaphase/anaphase transition anaphase-promoting complex-dependent catabolic process nuclear periphery positive regulation of mitotic metaphase/anaphase transition cell division protein K11-linked ubiquitination ubiquitin protein ligase activity uc008xkw.1 uc008xkw.2 uc008xkw.3 
ENSMUST00000031077.13 Zcchc4 ENSMUST00000031077.13 zinc finger, CCHC domain containing 4, transcript variant 1 (from RefSeq NM_030185.3) ENSMUST00000031077.1 ENSMUST00000031077.10 ENSMUST00000031077.11 ENSMUST00000031077.12 ENSMUST00000031077.2 ENSMUST00000031077.3 ENSMUST00000031077.4 ENSMUST00000031077.5 ENSMUST00000031077.6 ENSMUST00000031077.7 ENSMUST00000031077.8 ENSMUST00000031077.9 NM_030185 Q3UTX6 Q8BKW4 Q9D2I1 ZCHC4_MOUSE Zcchc4 uc008xku.1 uc008xku.2 uc008xku.3 uc008xku.4 rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation. Reaction=adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:58724, Rhea:RHEA-COMP:16142, Rhea:RHEA-COMP:16143, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; Evidence=; Interacts with components of the ASC-1 complex TRIP4, ASCC1, ASCC2 and ASCC3. Interact with AHCYL1 and AHCYL2. Interact with YTHDC2. Cytoplasm Nucleus, nucleolus Note=Accumulates in the nucleolus, where ribosome biogenesis takes place. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BKW4-1; Sequence=Displayed; Name=2; IsoId=Q8BKW4-2; Sequence=VSP_017013; The regulatory loop blocks the catalytic center by bridging the methyltransferase domain and the C-terminal CCHC-type zinc finger, resulting in an autoinhibitory conformation. Belongs to the ZCCHC4 family. nucleic acid binding nucleus nucleolus cytoplasm methyltransferase activity zinc ion binding rRNA (adenine-N6-)-methyltransferase activity transferase activity transferase activity, transferring acyl groups rRNA methylation methylation positive regulation of translation metal ion binding uc008xku.1 uc008xku.2 uc008xku.3 uc008xku.4 
ENSMUST00000031078.10 Cimip2c ENSMUST00000031078.10 ciliary microtubule inner protein 2C, transcript variant 1 (from RefSeq NM_029285.2) CMI2C_MOUSE ENSMUST00000031078.1 ENSMUST00000031078.2 ENSMUST00000031078.3 ENSMUST00000031078.4 ENSMUST00000031078.5 ENSMUST00000031078.6 ENSMUST00000031078.7 ENSMUST00000031078.8 ENSMUST00000031078.9 Fam166c NM_029285 Q9D9M8 Q9DAS2 uc008wvn.1 uc008wvn.2 uc008wvn.3 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Cytoplasm, cytoskeleton, cilium axoneme Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DAS2-1; Sequence=Displayed; Name=2; IsoId=Q9DAS2-2; Sequence=VSP_033372, VSP_033373; Belongs to the CIMIP2 family. molecular_function biological_process uc008wvn.1 uc008wvn.2 uc008wvn.3 
ENSMUST00000031080.15 Fam114a1 ENSMUST00000031080.15 family with sequence similarity 114, member A1 (from RefSeq NM_026667.4) ENSMUST00000031080.1 ENSMUST00000031080.10 ENSMUST00000031080.11 ENSMUST00000031080.12 ENSMUST00000031080.13 ENSMUST00000031080.14 ENSMUST00000031080.2 ENSMUST00000031080.3 ENSMUST00000031080.4 ENSMUST00000031080.5 ENSMUST00000031080.6 ENSMUST00000031080.7 ENSMUST00000031080.8 ENSMUST00000031080.9 NM_026667 NXP20_MOUSE Noxp20 Q8BMQ0 Q8R2U1 Q9D281 Q9D3K6 uc012dwn.1 uc012dwn.2 uc012dwn.3 May play a role in neuronal cell development. Cytoplasm. Over-expressed in brain. Also detected in lung, stomach, and in a lower extent in testis and thymus. At embryonic days 12 and 15, it is strongly expressed in the ventricular and intermediate zones of the brain and of the spinal cord. At postnatal day 10, it is detected in the dentate gyrus, the hippocampus, the cerebellum and the olfactory bulb. Belongs to the FAM114 family. molecular_function nucleus nucleoplasm cytoplasm Golgi apparatus cytosol biological_process uc012dwn.1 uc012dwn.2 uc012dwn.3 
ENSMUST00000031081.11 Pi4k2b ENSMUST00000031081.11 phosphatidylinositol 4-kinase type 2 beta, transcript variant 1 (from RefSeq NM_025951.3) ENSMUST00000031081.1 ENSMUST00000031081.10 ENSMUST00000031081.2 ENSMUST00000031081.3 ENSMUST00000031081.4 ENSMUST00000031081.5 ENSMUST00000031081.6 ENSMUST00000031081.7 ENSMUST00000031081.8 ENSMUST00000031081.9 NM_025951 P4K2B_MOUSE Q8CBQ5 Q91Z30 Q9D072 Q9D471 uc008xkq.1 uc008xkq.2 uc008xkq.3 uc008xkq.4 Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216; EC=2.7.1.67; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19878; Evidence=; Cytoplasm, cytosol Golgi apparatus membrane ; Peripheral membrane protein Endoplasmic reticulum membrane Cell membrane Early endosome membrane Note=Mainly cytosolic, association with membranes of the Golgi, endoplasmic and plasma membrane is stimulated by active RAC1. Association with early endosomes has not been confirmed. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CBQ5-1; Sequence=Displayed; Name=2; IsoId=Q8CBQ5-2; Sequence=VSP_024828; Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. nucleotide binding 1-phosphatidylinositol 4-kinase activity ATP binding cytoplasm endosome trans-Golgi network plasma membrane Golgi organization endosome organization membrane kinase activity phosphorylation transferase activity phosphatidylinositol phosphorylation uc008xkq.1 uc008xkq.2 uc008xkq.3 uc008xkq.4 
ENSMUST00000031090.8 Sel1l3 ENSMUST00000031090.8 sel-1 suppressor of lin-12-like 3 (C. elegans) (from RefSeq NM_172710.3) E9QPJ6 ENSMUST00000031090.1 ENSMUST00000031090.2 ENSMUST00000031090.3 ENSMUST00000031090.4 ENSMUST00000031090.5 ENSMUST00000031090.6 ENSMUST00000031090.7 Kiaa0746 NM_172710 Q148Y5 Q505D2 Q80TS8 Q8BMN0 Q8BYY3 Q8R0K7 SE1L3_MOUSE uc008xlc.1 uc008xlc.2 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80TS8-1; Sequence=Displayed; Name=2; IsoId=Q80TS8-2; Sequence=VSP_031813; Name=3; IsoId=Q80TS8-3; Sequence=VSP_031814, VSP_031815; Sequence=AAH26655.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC65644.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function nucleus nucleoplasm biological_process membrane integral component of membrane uc008xlc.1 uc008xlc.2 
ENSMUST00000031091.13 D5Ertd579e ENSMUST00000031091.13 DNA segment, Chr 5, ERATO Doi 579, expressed (from RefSeq NM_001081232.3) D5Ertd579e E9QPJ5 E9QPJ5_MOUSE ENSMUST00000031091.1 ENSMUST00000031091.10 ENSMUST00000031091.11 ENSMUST00000031091.12 ENSMUST00000031091.2 ENSMUST00000031091.3 ENSMUST00000031091.4 ENSMUST00000031091.5 ENSMUST00000031091.6 ENSMUST00000031091.7 ENSMUST00000031091.8 ENSMUST00000031091.9 NM_001081232 uc029vhc.1 uc029vhc.2 uc029vhc.3 uc029vhc.4 uc029vhc.5 uc029vhc.1 uc029vhc.2 uc029vhc.3 uc029vhc.4 uc029vhc.5 
ENSMUST00000031093.5 Cckar ENSMUST00000031093.5 cholecystokinin A receptor, transcript variant 1 (from RefSeq NM_009827.2) CCKAR_MOUSE ENSMUST00000031093.1 ENSMUST00000031093.2 ENSMUST00000031093.3 ENSMUST00000031093.4 NM_009827 O08786 Q8VCC7 Q9DBV6 uc008xlm.1 uc008xlm.2 uc008xlm.3 uc008xlm.4 uc008xlm.5 Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. temperature homeostasis gastric acid secretion neuron migration reduction of food intake in response to dietary excess G-protein coupled receptor activity cholecystokinin receptor activity cytoplasm lysosome endosome endoplasmic reticulum plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration axonogenesis feeding behavior response to heat membrane integral component of membrane peptide hormone binding insulin secretion pancreatic juice secretion forebrain development actin cytoskeleton reorganization cellular response to hormone stimulus cholecystokinin signaling pathway response to starvation eating behavior terminal bouton regulation of potassium ion transport regulation of hormone secretion regulation of calcium ion transport positive regulation of somatostatin secretion uc008xlm.1 uc008xlm.2 uc008xlm.3 uc008xlm.4 uc008xlm.5 
ENSMUST00000031096.11 Klb ENSMUST00000031096.11 klotho beta (from RefSeq NM_031180.2) B2RQN8 Betakl ENSMUST00000031096.1 ENSMUST00000031096.10 ENSMUST00000031096.2 ENSMUST00000031096.3 ENSMUST00000031096.4 ENSMUST00000031096.5 ENSMUST00000031096.6 ENSMUST00000031096.7 ENSMUST00000031096.8 ENSMUST00000031096.9 KLOTB_MOUSE NM_031180 Q920J2 Q99N31 Q99N32 uc008xnn.1 uc008xnn.2 uc008xnn.3 Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. Interacts with FGF19; this interaction is direct. Interacts (via C-terminus) with FGF21; this interaction is direct (By similarity). Interacts with FGFR1 and FGFR4. Q99N32; P16092: Fgfr1; NbExp=3; IntAct=EBI-15633521, EBI-7953898; Q99N32; Q03142: Fgfr4; NbExp=2; IntAct=EBI-15633521, EBI-15633599; Cell membrane ; Single-pass type III membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99N32-1; Sequence=Displayed; Name=2; IsoId=Q99N32-2; Sequence=VSP_015830, VSP_015831; Present in liver, muscle and white adipose tissue, but not in kidney (at protein level). Expressed in liver and pancreas, and at lower levels in skin, stomach, skeletal muscle, small intestine and lung. Expression starts at 10.5 dpc in hepatocytes. Expressed in the acinar cells of the pancreas and cervical brown adipose tissue at 15.5 dpc. Expressed in white adipose tissue at 19.5 dpc. Up-regulated during preadipocyte differentiation into adipocytes (at protein level). Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 241, and the second one lacks the essential Glu active site residue at position 887. These domains are therefore predicted to be inactive. Mice are viable and fertile, but have an altered bile metabolism: they have increased CYP7A1 levels, secrete more bile acids and are resistant to cholesterol gallstone formation. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. Sequence=AAL01648.1; Type=Erroneous initiation; Evidence=; hydrolase activity, hydrolyzing O-glycosyl compounds fibroblast growth factor receptor binding protein binding plasma membrane carbohydrate metabolic process positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway membrane integral component of membrane fibroblast growth factor binding positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway uc008xnn.1 uc008xnn.2 uc008xnn.3 
ENSMUST00000031097.8 Tada2b ENSMUST00000031097.8 transcriptional adaptor 2B (from RefSeq NM_001170454.1) D3Z4Z0 D3Z4Z0_MOUSE ENSMUST00000031097.1 ENSMUST00000031097.2 ENSMUST00000031097.3 ENSMUST00000031097.4 ENSMUST00000031097.5 ENSMUST00000031097.6 ENSMUST00000031097.7 NM_001170454 Tada2b uc012dvi.1 uc012dvi.2 Nucleus DNA binding chromatin binding transcription coactivator activity protein binding nucleus chromatin remodeling regulation of transcription from RNA polymerase II promoter zinc ion binding histone acetylation STAGA complex regulation of histone acetylation positive regulation of histone acetylation metal ion binding SAGA-type complex positive regulation of nucleic acid-templated transcription histone acetyltransferase activity uc012dvi.1 uc012dvi.2 
ENSMUST00000031099.4 Grpel1 ENSMUST00000031099.4 GrpE-like 1, mitochondrial (from RefSeq NM_024478.2) ENSMUST00000031099.1 ENSMUST00000031099.2 ENSMUST00000031099.3 GRPE1_MOUSE NM_024478 Q3TSZ3 Q99LP6 uc008xep.1 uc008xep.2 uc008xep.3 Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19. Binds to HSP70, HSC70 and HSJ1B (By similarity). Mitochondrion matrix Belongs to the GrpE family. adenyl-nucleotide exchange factor activity presequence translocase-associated import motor ATPase activator activity nucleus mitochondrion mitochondrial matrix protein folding protein import into mitochondrial matrix positive regulation of ATPase activity protein homodimerization activity regulation of catalytic activity unfolded protein binding chaperone binding ATPase binding uc008xep.1 uc008xep.2 uc008xep.3 
ENSMUST00000031103.14 Ugdh ENSMUST00000031103.14 UDP-glucose dehydrogenase (from RefSeq NM_009466.2) ENSMUST00000031103.1 ENSMUST00000031103.10 ENSMUST00000031103.11 ENSMUST00000031103.12 ENSMUST00000031103.13 ENSMUST00000031103.2 ENSMUST00000031103.3 ENSMUST00000031103.4 ENSMUST00000031103.5 ENSMUST00000031103.6 ENSMUST00000031103.7 ENSMUST00000031103.8 ENSMUST00000031103.9 NM_009466 Q3TS38 Q3TS38_MOUSE Ugdh uc008xns.1 uc008xns.2 uc008xns.3 uc008xns.4 Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP- alpha-D-glucuronate; Xref=Rhea:RHEA:23596, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885; EC=1.1.1.22; Evidence= Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1. Homohexamer. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. UDP-glucose 6-dehydrogenase activity nucleoplasm UDP-glucuronate biosynthetic process oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor protein hexamerization NAD binding oxidation-reduction process uc008xns.1 uc008xns.2 uc008xns.3 uc008xns.4 
ENSMUST00000031106.8 Rhoh ENSMUST00000031106.8 ras homolog family member H, transcript variant 2 (from RefSeq NM_001363454.1) Arhh ENSMUST00000031106.1 ENSMUST00000031106.2 ENSMUST00000031106.3 ENSMUST00000031106.4 ENSMUST00000031106.5 ENSMUST00000031106.6 ENSMUST00000031106.7 NM_001363454 Q9D3G9 RHOH_MOUSE uc008xoc.1 uc008xoc.2 uc008xoc.3 Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils (By similarity). Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70 (PubMed:17028588). Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells. Interacts with GDI1 and GDI2 (By similarity). Interacts with ZAP70 (via SH2 domains) and the interaction is enhanced by its phosphorylation by LCK. Interacts with SYK and the interaction is enhanced by its phosphorylation by FYN. Cytoplasm Cell membrane ; Lipid-anchor ; Cytoplasmic side Note=Colocalizes together with ZAP70 in the immunological synapse. Expression is widespread in hematopoietic cells, including in bone marrow progenitor cells and in differentiated myeloid as well as lymphoid cells. Expressed at high levels in the thymus and mast cells, found in spleen and low-density bone marrow (LDBM) cells and is detected at a low level in neutrophils. In the thymus it is detected in thymocytes of the thymic cortex but not in non-lymphoid cells of fibrovascular and fibroadipose tissues. Expressed in T-cells, B-cells and mast cells. Expressed at all stages of thymocyte development, with relative peaks at the DN3 and DP stages. The region involved in interaction with ZAP70 is a non- canonical immunoreceptor tyrosine-based activation motif (ITAM). Phosphorylated on tyrosine by LCK. Phosphorylated by FYN. Phosphorylation enhances the interactions with ZAP70 and SYK and is critical for its function in thymocyte development. Knockout mice have smaller thymuses than wild- type animals, and T-cell lymphopenia due to defects in T-cell maturation and population expansion in the thymus (PubMed:17028588). Mice show impaired passive systemic anaphylaxis and histamine release upon challenge with the specific antigen. Belongs to the small GTPase superfamily. Rho family. nucleotide binding immunological synapse GTPase activity protein binding GTP binding cytoplasm plasma membrane small GTPase mediated signal transduction Rho protein signal transduction membrane kinase inhibitor activity T cell differentiation negative regulation of kinase activity negative regulation of I-kappaB kinase/NF-kappaB signaling mast cell activation positive regulation of T cell differentiation uc008xoc.1 uc008xoc.2 uc008xoc.3 
ENSMUST00000031108.9 Chrna9 ENSMUST00000031108.9 cholinergic receptor, nicotinic, alpha polypeptide 9, transcript variant 5 (from RefSeq NM_001403684.1) Chrna9 ENSMUST00000031108.1 ENSMUST00000031108.2 ENSMUST00000031108.3 ENSMUST00000031108.4 ENSMUST00000031108.5 ENSMUST00000031108.6 ENSMUST00000031108.7 ENSMUST00000031108.8 G3X8Z7 G3X8Z7_MOUSE NM_001403684 uc008xog.1 uc008xog.2 uc008xog.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity protein binding plasma membrane integral component of plasma membrane acetylcholine-gated channel complex ion transport cation transport signal transduction positive regulation of cytosolic calcium ion concentration chemical synaptic transmission sensory perception of sound membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction ion transmembrane transport regulation of membrane potential inner ear morphogenesis neuron projection synapse postsynaptic membrane neurological system process detection of mechanical stimulus involved in sensory perception of sound regulation of postsynaptic membrane potential excitatory postsynaptic potential negative regulation of ERK1 and ERK2 cascade cholinergic synapse integral component of postsynaptic specialization membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc008xog.1 uc008xog.2 uc008xog.3 
ENSMUST00000031117.13 Gnpda2 ENSMUST00000031117.13 glucosamine-6-phosphate deaminase 2, transcript variant 1 (from RefSeq NM_001038015.2) ENSMUST00000031117.1 ENSMUST00000031117.10 ENSMUST00000031117.11 ENSMUST00000031117.12 ENSMUST00000031117.2 ENSMUST00000031117.3 ENSMUST00000031117.4 ENSMUST00000031117.5 ENSMUST00000031117.6 ENSMUST00000031117.7 ENSMUST00000031117.8 ENSMUST00000031117.9 GNPI2_MOUSE Kiaa4008 NM_001038015 Q3TH02 Q9CRC9 Q9D457 uc008xqq.1 uc008xqq.2 uc008xqq.3 uc008xqq.4 Catalyzes the reversible conversion of alpha-D-glucosamine 6- phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. Reaction=alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6- phosphate + NH4(+); Xref=Rhea:RHEA:12172, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57634, ChEBI:CHEBI:75989; EC=3.5.99.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12173; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:12174; Evidence=; Allosterically activated by N-acetylglucosamine-6- phosphate (GlcNAc6P). Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D- fructose 6-phosphate: step 1/1. Homohexamer. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CRC9-1; Sequence=Displayed; Name=2; IsoId=Q9CRC9-2; Sequence=VSP_034581; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. glucosamine-6-phosphate deaminase activity cytoplasm carbohydrate metabolic process glucosamine catabolic process N-acetylglucosamine metabolic process N-acetylglucosamine catabolic process UDP-N-acetylglucosamine biosynthetic process hydrolase activity N-acetylneuraminate catabolic process identical protein binding uc008xqq.1 uc008xqq.2 uc008xqq.3 uc008xqq.4 
ENSMUST00000031119.6 Gabrg1 ENSMUST00000031119.6 gamma-aminobutyric acid type A receptor subunit gamma 1, transcript variant 6 (from RefSeq NR_184456.1) ENSMUST00000031119.1 ENSMUST00000031119.2 ENSMUST00000031119.3 ENSMUST00000031119.4 ENSMUST00000031119.5 GBRG1_MOUSE NR_184456 Q8BHM6 Q9R0Y8 uc008xqr.1 uc008xqr.2 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. May be palmitoylated. This subunit carries the benzodiazepine binding site. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG1 sub- subfamily. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity inhibitory extracellular ligand-gated ion channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction gamma-aminobutyric acid signaling pathway chemical synaptic transmission membrane integral component of membrane GABA-gated chloride ion channel activity cell junction dendrite membrane ion transmembrane transport chloride channel complex regulation of membrane potential neuron projection receptor complex synapse postsynaptic membrane GABA receptor binding neurological system process synaptic transmission, GABAergic regulation of postsynaptic membrane potential postsynapse chloride transmembrane transport GABA-A receptor complex transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential benzodiazepine receptor activity uc008xqr.1 uc008xqr.2 
ENSMUST00000031121.10 Gabra4 ENSMUST00000031121.10 gamma-aminobutyric acid type A receptor subunit alpha 4, transcript variant 2 (from RefSeq NM_010251.2) ENSMUST00000031121.1 ENSMUST00000031121.2 ENSMUST00000031121.3 ENSMUST00000031121.4 ENSMUST00000031121.5 ENSMUST00000031121.6 ENSMUST00000031121.7 ENSMUST00000031121.8 ENSMUST00000031121.9 GBRA4_MOUSE NM_010251 Q9D6F4 uc008xqy.1 uc008xqy.2 uc008xqy.3 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub- subfamily. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity inhibitory extracellular ligand-gated ion channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction gamma-aminobutyric acid signaling pathway chemical synaptic transmission central nervous system development membrane integral component of membrane GABA-gated chloride ion channel activity cell junction dendrite membrane ion transmembrane transport chloride channel complex regulation of membrane potential neuron projection synapse postsynaptic membrane neurological system process synaptic transmission, GABAergic regulation of postsynaptic membrane potential postsynapse GABA-ergic synapse integral component of postsynaptic specialization membrane chloride transmembrane transport GABA-A receptor complex transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential regulation of response to drug benzodiazepine receptor activity uc008xqy.1 uc008xqy.2 uc008xqy.3 
ENSMUST00000031122.9 Gabrb1 ENSMUST00000031122.9 gamma-aminobutyric acid type A receptor subunit beta 1, transcript variant 1 (from RefSeq NM_008069.5) ENSMUST00000031122.1 ENSMUST00000031122.2 ENSMUST00000031122.3 ENSMUST00000031122.4 ENSMUST00000031122.5 ENSMUST00000031122.6 ENSMUST00000031122.7 ENSMUST00000031122.8 Gabrb1 NM_008069 Q53WT3 Q53WT3_MOUSE uc008xrb.1 uc008xrb.2 uc008xrb.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity anion channel activity nucleus nuclear envelope cytoplasm plasma membrane integral component of plasma membrane ion transport gamma-aminobutyric acid signaling pathway response to toxic substance ligand-gated ion channel activity membrane integral component of membrane central nervous system neuron development GABA-gated chloride ion channel activity dendrite response to progesterone ion transmembrane transport ovulation cycle receptor complex GABA receptor binding regulation of postsynaptic membrane potential cellular response to histamine GABA-ergic synapse chloride transmembrane transport GABA-A receptor complex transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc008xrb.1 uc008xrb.2 uc008xrb.3 
ENSMUST00000031124.7 Slc10a4-ps ENSMUST00000031124.7 solute carrier family 10 (sodium/bile acid cotransporter family), pseudogene (from RefSeq NR_163693.1) EG545758 ENSMUST00000031124.1 ENSMUST00000031124.2 ENSMUST00000031124.3 ENSMUST00000031124.4 ENSMUST00000031124.5 ENSMUST00000031124.6 Gm5868 NR_163693 Q8BJG1 Q8BJG1_MOUSE Slc10a4-ps Slc10a4l uc008xrq.1 uc008xrq.2 uc008xrq.3 Membrane ; Multi- pass membrane protein Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. bile acid:sodium symporter activity bile acid and bile salt transport membrane integral component of membrane uc008xrq.1 uc008xrq.2 uc008xrq.3 
ENSMUST00000031127.11 Slc10a4 ENSMUST00000031127.11 solute carrier family 10 (sodium/bile acid cotransporter family), member 4 (from RefSeq NM_173403.2) ENSMUST00000031127.1 ENSMUST00000031127.10 ENSMUST00000031127.2 ENSMUST00000031127.3 ENSMUST00000031127.4 ENSMUST00000031127.5 ENSMUST00000031127.6 ENSMUST00000031127.7 ENSMUST00000031127.8 ENSMUST00000031127.9 NM_173403 NTCP4_MOUSE Q3UEZ8 Q8BJC7 uc008xsk.1 uc008xsk.2 uc008xsk.3 Transporter for bile acids. Cell membrane ; Multi-pass membrane protein Highest expression in the brain and significantly above background levels in the eye, prostate, and whole embryo tissue preparations. Activated following N-terminal proteolytic cleavage by thrombin and/or proteases. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. plasma membrane ion transport sodium ion transport bile acid:sodium symporter activity symporter activity bile acid and bile salt transport membrane integral component of membrane integral component of synaptic vesicle membrane adult behavior response to drug transmembrane transport cholinergic synapse uc008xsk.1 uc008xsk.2 uc008xsk.3 
ENSMUST00000031131.11 Uchl1 ENSMUST00000031131.11 ubiquitin carboxy-terminal hydrolase L1 (from RefSeq NM_011670.2) ENSMUST00000031131.1 ENSMUST00000031131.10 ENSMUST00000031131.2 ENSMUST00000031131.3 ENSMUST00000031131.4 ENSMUST00000031131.5 ENSMUST00000031131.6 ENSMUST00000031131.7 ENSMUST00000031131.8 ENSMUST00000031131.9 NM_011670 Q9R0P9 Q9R122 UCHL1_MOUSE uc008xpf.1 uc008xpf.2 uc008xpf.3 uc008xpf.4 Deubiquitinase that plays a role in the regulation of several processes such as maintenance of synaptic function, cardiac function, inflammatory response or osteoclastogenesis (PubMed:31492742, PubMed:32494592, PubMed:37215988). Abrogates the ubiquitination of multiple proteins including WWTR1/TAZ, EGFR, HIF1A and beta-site amyloid precursor protein cleaving enzyme 1/BACE1. In addition, recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin to maintain a stable pool of monoubiquitin that is a key requirement for the ubiquitin-proteasome and the autophagy-lysosome pathways (By similarity). Regulates amyloid precursor protein/APP processing by promoting BACE1 degradation resulting in decreased amyloid beta production (By similarity). Plays a role in the immune response by regulating the ability of MHC I molecules to reach cross- presentation compartments competent for generating Ag-MHC I complexes (PubMed:31492742). Mediates the 'Lys-48'-linked deubiquitination of the transcriptional coactivator WWTR1/TAZ leading to its stabilization and inhibition of osteoclastogenesis (PubMed:37215988). Deubiquitinates and stabilizes epidermal growth factor receptor EGFR to prevent its degradation and to activate its downstream mediators (PubMed:32494592). Modulates oxidative activity in skeletal muscle by regulating key mitochondrial oxidative proteins (PubMed:33137160). Enhances the activity of hypoxia-inducible factor 1-alpha/HIF1A by abrogateing its VHL E3 ligase-mediated ubiquitination and consequently inhibiting its degradation (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence= Kinetic parameters: KM=116 nM for Ub-AMC ; Monomer. Homodimer. Interacts with COPS5 and SNCA (By similarity). Cytoplasm doplasmic reticulum membrane ; Lipid-anchor Note=Localizes near and/or within mitochondria to potentially interact with mitochondrial proteins. Expressed in brain, where it is found in neurons but not in oligodendrocytes or astrocytes. Found in the ganglion cell layer and the inner nuclear layer of the retina (at protein level). Expressed in brain and testis. In the brain, expression is at its lowest in replaceable neurons of hippocampus and olfactory bulb. Highly expressed in senescent pituitary. In skeletal muscle, primarily expressed in oxidative muscle fibers (PubMed:33137160). By LPS, whereas stimulation with IFN-gamma decreases expression. O-glycosylated. Mice show sensory ataxia at an early stage, followed by motor ataxia at a later stage. They have reduced levels of monoubiquitin in the nervous system, and increased resistance to retinal ischemia. In addition, a significant reduction in the generation and proliferation of Ag-specific CD8, but not CD4, T-cells is observed showing that the deletion affects the ability to mount an Ag-specific CD8 T-cell response (PubMed:31492742). UCHL1-skeletal muscle specific gene knockout leads to reduced oxidative muscle fibers and oxidative activity (PubMed:33137160). In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8. Belongs to the peptidase C12 family. The homodimer may have ATP-independent ubiquitin ligase activity. However, in another study, UCHL1 was shown to lack ubiquitin ligase activity. response to ischemia cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane proteolysis ubiquitin-dependent protein catabolic process axonogenesis axon target recognition adult walking behavior peptidase activity cysteine-type peptidase activity omega peptidase activity cell proliferation membrane protein deubiquitination hydrolase activity ligase activity sensory perception of pain axonal transport of mitochondrion axon ubiquitin protein ligase binding alpha-2A adrenergic receptor binding thiol-dependent ubiquitinyl hydrolase activity eating behavior neuronal cell body ubiquitin binding myelin sheath negative regulation of MAP kinase activity neuron projection terminus muscle fiber development neuromuscular process axon cytoplasm uc008xpf.1 uc008xpf.2 uc008xpf.3 uc008xpf.4 
ENSMUST00000031143.13 Srd5a3 ENSMUST00000031143.13 steroid 5 alpha-reductase 3 (from RefSeq NM_020611.4) D3YZB6 D3Z3J5 ENSMUST00000031143.1 ENSMUST00000031143.10 ENSMUST00000031143.11 ENSMUST00000031143.12 ENSMUST00000031143.2 ENSMUST00000031143.3 ENSMUST00000031143.4 ENSMUST00000031143.5 ENSMUST00000031143.6 ENSMUST00000031143.7 ENSMUST00000031143.8 ENSMUST00000031143.9 NM_020611 PORED_MOUSE Q3UU82 Q8BGE3 Q9WUP4 Srd5a2l Srd5a3 uc008xuo.1 uc008xuo.2 uc008xuo.3 uc008xuo.4 Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol (PubMed:20637498). Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation (PubMed:20637498). Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (PubMed:20637498). Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (By similarity). Reaction=di-trans,poly-cis-dolichol + NADP(+) = di-trans,cis-polyprenol + H(+) + NADPH; Xref=Rhea:RHEA:34279, Rhea:RHEA-COMP:9521, Rhea:RHEA- COMP:9525, ChEBI:CHEBI:15378, ChEBI:CHEBI:16091, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:67132; EC=1.3.1.94; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:34281; Evidence=; Reaction=a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH; Xref=Rhea:RHEA:54384, ChEBI:CHEBI:13601, ChEBI:CHEBI:15378, ChEBI:CHEBI:47909, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.22; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:54386; Evidence=; Reaction=androst-4-ene-3,17-dione + H(+) + NADPH = 5alpha-androstan- 3,17-dione + NADP(+); Xref=Rhea:RHEA:50816, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:16422, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50818; Evidence=; Reaction=17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = H(+) + NADPH + testosterone; Xref=Rhea:RHEA:50820, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:17347, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.22; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50822; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WUP4-1; Sequence=Displayed; Name=2; IsoId=Q9WUP4-2; Sequence=VSP_039779; Death by 12.5 dpc. At 10.5 dpc, embryos are smaller and fail to undergo axial rotation observed at 8.5 dpc in wild- types and present dilated hearts and open neural tubes. Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily. 3-oxo-5-alpha-steroid 4-dehydrogenase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation dolichol-linked oligosaccharide biosynthetic process lipid metabolic process membrane integral component of membrane polyprenol catabolic process oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor dolichol metabolic process dolichol biosynthetic process cholestenone 5-alpha-reductase activity oxidation-reduction process uc008xuo.1 uc008xuo.2 uc008xuo.3 uc008xuo.4 
ENSMUST00000031144.14 Tmem165 ENSMUST00000031144.14 transmembrane protein 165 (from RefSeq NM_011626.2) ENSMUST00000031144.1 ENSMUST00000031144.10 ENSMUST00000031144.11 ENSMUST00000031144.12 ENSMUST00000031144.13 ENSMUST00000031144.2 ENSMUST00000031144.3 ENSMUST00000031144.4 ENSMUST00000031144.5 ENSMUST00000031144.6 ENSMUST00000031144.7 ENSMUST00000031144.8 ENSMUST00000031144.9 NM_011626 P52875 Q9R292 TM165_MOUSE Tmem165 Tparl uc008xup.1 uc008xup.2 uc008xup.3 Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (By similarity). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (PubMed:30622138). The transport mechanism and stoichiometry remains to be elucidated (By similarity). Reaction=Ca(2+)(in) + n H(+)(out) = Ca(2+)(out) + n H(+)(in); Xref=Rhea:RHEA:76631, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108; Evidence=; Reaction=n H(+)(out) + Mn(2+)(in) = n H(+)(in) + Mn(2+)(out); Xref=Rhea:RHEA:76635, ChEBI:CHEBI:15378, ChEBI:CHEBI:29035; Evidence=; Golgi apparatus membrane ; Multi-pass membrane protein Expressed in mammary epithelial cells (at protein level). Expressed in undifferentiated mouse F9 teratocarcinoma stem cells but disappearing rapidly after treatment with a tumor-promoting phorbol ester. Belongs to the GDT1 family. Sequence=AAA40456.1; Type=Frameshift; Evidence=; Golgi membrane molecular_function lysosome lysosomal membrane endosome Golgi apparatus protein N-linked glycosylation cellular calcium ion homeostasis endosome membrane membrane integral component of membrane early endosome membrane late endosome membrane Golgi calcium ion transport trans-Golgi network membrane regulation of lysosomal lumen pH intracellular membrane-bounded organelle uc008xup.1 uc008xup.2 uc008xup.3 
ENSMUST00000031145.7 Pdcl2 ENSMUST00000031145.7 phosducin-like 2, transcript variant 1 (from RefSeq NM_023508.7) ENSMUST00000031145.1 ENSMUST00000031145.2 ENSMUST00000031145.3 ENSMUST00000031145.4 ENSMUST00000031145.5 ENSMUST00000031145.6 NM_023508 PDCL2_MOUSE Q3V0H7 Q78Y63 Q9DA99 Q9WUP3 uc008xuu.1 uc008xuu.2 uc008xuu.3 uc008xuu.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q78Y63-1; Sequence=Displayed; Name=2; IsoId=Q78Y63-2; Sequence=VSP_022360; Belongs to the phosducin family. Reported to be expressed in male and female germ cells, to be up-regulated at the protein level as early as 3 hours after chorionic gonadotropin treatment in the ovary, and to interact with 14-3-3 proteins (PubMed:12424248). However, the publication has been retracted due to image duplication and manipulation. The nucleotide sequence has been confirmed by other studies (PubMed:11116088). uc008xuu.1 uc008xuu.2 uc008xuu.3 uc008xuu.4 
ENSMUST00000031146.3 Nmu ENSMUST00000031146.3 neuromedin U (from RefSeq NM_019515.1) ENSMUST00000031146.1 ENSMUST00000031146.2 NMU_MOUSE NM_019515 Q9QXK8 uc008xuw.1 uc008xuw.2 uc008xuw.3 [Neuromedin-U-23]: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. [Neuromedin precursor-related peptide 33]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36. [Neuromedin precursor-related peptide 36]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. Stimulates muscle contractions of specific regions of the gastrointestinal tract. Secreted. Belongs to the NmU family. temperature homeostasis gastric acid secretion extracellular region regulation of smooth muscle contraction positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway photoperiodism positive regulation of heart rate sensory perception of pain positive regulation of heat generation type 1 neuromedin U receptor binding type 2 neuromedin U receptor binding eating behavior neuromedin U receptor binding terminal bouton positive regulation of blood pressure in other organism regulation of circadian sleep/wake cycle, sleep positive regulation of smooth muscle contraction positive regulation of hormone secretion positive regulation of synaptic transmission regulation of feeding behavior negative regulation of gastric acid secretion energy homeostasis positive regulation of prolactin secretion negative regulation of eating behavior positive regulation of sensory perception of pain negative regulation of feeding behavior regulation of grooming behavior uc008xuw.1 uc008xuw.2 uc008xuw.3 
ENSMUST00000031160.16 Paics ENSMUST00000031160.16 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase, transcript variant 1 (from RefSeq NM_025939.3) ENSMUST00000031160.1 ENSMUST00000031160.10 ENSMUST00000031160.11 ENSMUST00000031160.12 ENSMUST00000031160.13 ENSMUST00000031160.14 ENSMUST00000031160.15 ENSMUST00000031160.2 ENSMUST00000031160.3 ENSMUST00000031160.4 ENSMUST00000031160.5 ENSMUST00000031160.6 ENSMUST00000031160.7 ENSMUST00000031160.8 ENSMUST00000031160.9 NM_025939 PUR6_MOUSE Paics Q9CQ38 Q9DCL9 uc008xvo.1 uc008xvo.2 uc008xvo.3 uc008xvo.4 Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole- 4-carboxamido]succinate + ADP + 2 H(+) + phosphate; Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443, ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22629; Evidence=; Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2; Xref=Rhea:RHEA:10792, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:77657, ChEBI:CHEBI:137981; EC=4.1.1.21; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:10794; Evidence=; Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5- phospho-D-ribosyl)imidazole (carboxylase route): step 1/1. Homooctamer. In the N-terminal section; belongs to the SAICAR synthetase family. In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily. nucleotide binding catalytic activity phosphoribosylaminoimidazole carboxylase activity phosphoribosylaminoimidazolesuccinocarboxamide synthase activity ATP binding cytoplasm cytosol purine nucleotide biosynthetic process 'de novo' IMP biosynthetic process metabolic process lyase activity carboxy-lyase activity ligase activity identical protein binding 5-amino-4-imidazole carboxylate lyase activity uc008xvo.1 uc008xvo.2 uc008xvo.3 uc008xvo.4 
ENSMUST00000031167.6 Polr2b ENSMUST00000031167.6 polymerase (RNA) II (DNA directed) polypeptide B (from RefSeq NM_153798.2) ENSMUST00000031167.1 ENSMUST00000031167.2 ENSMUST00000031167.3 ENSMUST00000031167.4 ENSMUST00000031167.5 NM_153798 Q8CFI7 RPB2_MOUSE uc008xwe.1 uc008xwe.2 uc008xwe.3 uc008xwe.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity). Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA- COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.6; Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with WDR82 (By similarity). Interacts with MEN1 (By similarity). Nucleus The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits (By similarity). Belongs to the RNA polymerase beta chain family. Sequence=AAH38472.1; Type=Erroneous initiation; Evidence=; nuclear chromosome, telomeric region DNA binding chromatin binding DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm DNA-directed RNA polymerase II, core complex transcription, DNA-templated transcription from RNA polymerase II promoter transferase activity nucleotidyltransferase activity ribonucleoside binding metal ion binding RNA polymerase II activity uc008xwe.1 uc008xwe.2 uc008xwe.3 uc008xwe.4 
ENSMUST00000031170.10 Cenpc1 ENSMUST00000031170.10 centromere protein C1, transcript variant 2 (from RefSeq NM_007683.4) B9EK81 CENPC_MOUSE Cenpc ENSMUST00000031170.1 ENSMUST00000031170.2 ENSMUST00000031170.3 ENSMUST00000031170.4 ENSMUST00000031170.5 ENSMUST00000031170.6 ENSMUST00000031170.7 ENSMUST00000031170.8 ENSMUST00000031170.9 NM_007683 P49452 uc008xxc.1 uc008xxc.2 uc008xxc.3 uc008xxc.4 This gene encodes a centromeric protein component of a nucleosome-associated complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. The human ortholog encodes a protein with DNA-binding activity, that associates constitutively to kinetochores throughout the cell cycle, as part of a prekinetochore complex, together with centromeric protein-A and centromeric protein-B. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. Oligomer. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX. Interacts with DNMT3B. Interacts directly with CENPA. Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (By similarity). Interacts with MEIKIN (PubMed:25533956). P49452; Q5F2C3: Meikin; NbExp=5; IntAct=EBI-1186252, EBI-20739301; P49452; O08586: Pten; NbExp=2; IntAct=EBI-1186252, EBI-1186266; Nucleus Chromosome, centromere, kinetochore Chromosome, centromere Note=Localizes exclusively in the kinetochore domain of centromeres. The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization. Belongs to the CENP-C/MIF2 family. mitotic cell cycle chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed nuclear chromosome kinetochore condensed nuclear chromosome, centromeric region DNA binding protein binding nucleus nucleoplasm chromosome pericentric heterochromatin cytosol cell cycle chromosome segregation nuclear body centromeric DNA binding midbody nuclear pericentric heterochromatin cleavage furrow identical protein binding intercellular bridge cell division attachment of mitotic spindle microtubules to kinetochore kinetochore assembly attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation Flemming body uc008xxc.1 uc008xxc.2 uc008xxc.3 uc008xxc.4 
ENSMUST00000031172.9 Gnrhr ENSMUST00000031172.9 gonadotropin releasing hormone receptor, transcript variant 1 (from RefSeq NM_010323.2) ENSMUST00000031172.1 ENSMUST00000031172.2 ENSMUST00000031172.3 ENSMUST00000031172.4 ENSMUST00000031172.5 ENSMUST00000031172.6 ENSMUST00000031172.7 ENSMUST00000031172.8 GNRHR_MOUSE NM_010323 Q01776 Q61611 uc008xxl.1 uc008xxl.2 uc008xxl.3 uc008xxl.4 Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system. Cell membrane; Multi-pass membrane protein. Pituitary gland. Expressed in the developing pituitary gland at 18.5 dpc. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity gonadotropin-releasing hormone receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway negative regulation of cell proliferation membrane integral component of membrane protein-hormone receptor activity growth hormone-releasing hormone receptor activity cellular response to hormone stimulus cellular response to gonadotropin-releasing hormone uc008xxl.1 uc008xxl.2 uc008xxl.3 uc008xxl.4 
ENSMUST00000031175.12 Tmprss11d ENSMUST00000031175.12 transmembrane protease, serine 11d (from RefSeq NM_145561.2) ENSMUST00000031175.1 ENSMUST00000031175.10 ENSMUST00000031175.11 ENSMUST00000031175.2 ENSMUST00000031175.3 ENSMUST00000031175.4 ENSMUST00000031175.5 ENSMUST00000031175.6 ENSMUST00000031175.7 ENSMUST00000031175.8 ENSMUST00000031175.9 Mat NM_145561 Q7TNX3 Q8VDV1 Q8VHK8 TM11D_MOUSE uc008xxp.1 uc008xxp.2 uc008xxp.3 May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides (By similarity). Plays a role in the proteolytic processing of ACE2. Isoform 2 may play a key role in regulating adrenal proliferation by specifically cleaving N-POMC. Monomer. Cell membrane ; Single-pass type II membrane protein [Transmembrane protease serine 11D catalytic chain]: Secreted Note=Activated by cleavage and secreted. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=MAT1; IsoId=Q8VHK8-1; Sequence=Displayed; Name=2; Synonyms=MAT2; IsoId=Q8VHK8-2; Sequence=VSP_014519, VSP_014520; Highly expressed in the esophagus, tongue, and trachea, low expression was seen in heart, lung, and adrenal gland. Isoform 2 is also highly expressed in the adrenal gland. Belongs to the peptidase S1 family. serine-type endopeptidase activity extracellular region plasma membrane integral component of plasma membrane proteolysis peptidase activity serine-type peptidase activity cell surface membrane integral component of membrane hydrolase activity proteolysis in other organism regulation of growth viral entry into host cell uc008xxp.1 uc008xxp.2 uc008xxp.3 
ENSMUST00000031181.16 Ugt2b34 ENSMUST00000031181.16 UDP glucuronosyltransferase 2 family, polypeptide B34 (from RefSeq NM_153598.3) AI788959 ENSMUST00000031181.1 ENSMUST00000031181.10 ENSMUST00000031181.11 ENSMUST00000031181.12 ENSMUST00000031181.13 ENSMUST00000031181.14 ENSMUST00000031181.15 ENSMUST00000031181.2 ENSMUST00000031181.3 ENSMUST00000031181.4 ENSMUST00000031181.5 ENSMUST00000031181.6 ENSMUST00000031181.7 ENSMUST00000031181.8 ENSMUST00000031181.9 NM_153598 Q8K154 Q8K154_MOUSE Ugt2b34 uc008xyb.1 uc008xyb.2 uc008xyb.3 Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; Membrane ; Single- pass membrane protein Belongs to the UDP-glycosyltransferase family. UDP-glycosyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups intracellular membrane-bounded organelle uc008xyb.1 uc008xyb.2 uc008xyb.3 
ENSMUST00000031183.3 Ugt2b1 ENSMUST00000031183.3 UDP glucuronosyltransferase 2 family, polypeptide B1 (from RefSeq NM_152811.1) ENSMUST00000031183.1 ENSMUST00000031183.2 NM_152811 Q8R084 Q8R084_MOUSE Ugt2b1 uc008xyc.1 uc008xyc.2 uc008xyc.3 Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; Membrane ; Single- pass membrane protein Belongs to the UDP-glycosyltransferase family. UDP-glycosyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups response to lipopolysaccharide intracellular membrane-bounded organelle cellular glucuronidation biphenyl catabolic process cellular response to ethanol cellular response to growth hormone stimulus cellular response to glucocorticoid stimulus cellular response to testosterone stimulus uc008xyc.1 uc008xyc.2 uc008xyc.3 
ENSMUST00000031186.9 Ugt2b35 ENSMUST00000031186.9 UDP glucuronosyltransferase 2 family, polypeptide B35 (from RefSeq NM_172881.3) ENSMUST00000031186.1 ENSMUST00000031186.2 ENSMUST00000031186.3 ENSMUST00000031186.4 ENSMUST00000031186.5 ENSMUST00000031186.6 ENSMUST00000031186.7 ENSMUST00000031186.8 NM_172881 Q8BJL9 Q8BJL9_MOUSE Ugt2b35 uc008xyd.1 uc008xyd.2 uc008xyd.3 Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; Membrane ; Single- pass membrane protein Belongs to the UDP-glycosyltransferase family. UDP-glycosyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups intracellular membrane-bounded organelle uc008xyd.1 uc008xyd.2 uc008xyd.3 
ENSMUST00000031190.5 Dr1 ENSMUST00000031190.5 down-regulator of transcription 1 (from RefSeq NM_026106.4) ENSMUST00000031190.1 ENSMUST00000031190.2 ENSMUST00000031190.3 ENSMUST00000031190.4 NC2B_MOUSE NM_026106 Q3UT14 Q91WV0 uc008ynt.1 uc008ynt.2 uc008ynt.3 The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). Heterodimer with DRAP1. DR1 exists in solution as a homotetramer that dissociates during interaction with TBP and then, after complexing with TBP, reassociates at a slow rate, to reconstitute the tetramer. Interacts with NFIL3. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (By similarity). Nucleus Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1 (By similarity). Belongs to the NC2 beta/DR1 family. negative regulation of transcription from RNA polymerase II promoter core promoter binding DNA binding transcription corepressor activity protein binding nucleus Ada2/Gcn5/Ada3 transcription activator complex chromatin remodeling TBP-class protein binding negative cofactor 2 complex histone H3 acetylation regulation of RNA polymerase II transcriptional preinitiation complex assembly positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity transcription coactivator activity uc008ynt.1 uc008ynt.2 uc008ynt.3 
ENSMUST00000031195.3 Ugt2a3 ENSMUST00000031195.3 UDP glucuronosyltransferase 2 family, polypeptide A3 (from RefSeq NM_028094.4) ENSMUST00000031195.1 ENSMUST00000031195.2 NM_028094 Q8BWQ1 Q8R129 Q9D811 UD2A3_MOUSE uc008xyh.1 uc008xyh.2 uc008xyh.3 UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Membrane ; Single-pass type I membrane protein Highly expressed in liver, with lower levels in duodenum and jejunum. Belongs to the UDP-glycosyltransferase family. UDP-glycosyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups intracellular membrane-bounded organelle cellular glucuronidation uc008xyh.1 uc008xyh.2 uc008xyh.3 
ENSMUST00000031198.11 Dipk1a ENSMUST00000031198.11 divergent protein kinase domain 1A (from RefSeq NM_026062.4) DIK1A_MOUSE ENSMUST00000031198.1 ENSMUST00000031198.10 ENSMUST00000031198.2 ENSMUST00000031198.3 ENSMUST00000031198.4 ENSMUST00000031198.5 ENSMUST00000031198.6 ENSMUST00000031198.7 ENSMUST00000031198.8 ENSMUST00000031198.9 Fam69a NM_026062 Q3U5P1 Q3V308 Q9D6I7 uc008yni.1 uc008yni.2 uc008yni.3 uc008yni.4 Endoplasmic reticulum membrane ; Single-pass type II membrane protein Ubiquitous. Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds. Belongs to the DIPK family. protein binding cellular_component endoplasmic reticulum endoplasmic reticulum membrane biological_process membrane integral component of membrane uc008yni.1 uc008yni.2 uc008yni.3 uc008yni.4 
ENSMUST00000031199.11 Sult1b1 ENSMUST00000031199.11 sulfotransferase family 1B, member 1, transcript variant 2 (from RefSeq NM_019878.4) ENSMUST00000031199.1 ENSMUST00000031199.10 ENSMUST00000031199.2 ENSMUST00000031199.3 ENSMUST00000031199.4 ENSMUST00000031199.5 ENSMUST00000031199.6 ENSMUST00000031199.7 ENSMUST00000031199.8 ENSMUST00000031199.9 NM_019878 Q8C301 Q9QWG7 Q9Z2T0 ST1B1_MOUSE Sult1b1 uc008xyn.1 uc008xyn.2 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:9644246). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (By similarity). Reaction=3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'- bisphosphate + an aryl sulfate + H(+); Xref=Rhea:RHEA:12164, ChEBI:CHEBI:15378, ChEBI:CHEBI:33853, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:140317; EC=2.8.2.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12165; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine = 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:67876, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:176511, ChEBI:CHEBI:533015; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67877; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine = 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:67888, ChEBI:CHEBI:15378, ChEBI:CHEBI:57261, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:176513; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67889; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine = 3,3'- diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:67892, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:176514, ChEBI:CHEBI:176515; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67893; Evidence=; Reaction=3'-phosphoadenylyl sulfate + dopamine = adenosine 3',5'- bisphosphate + dopamine 3-O-sulfate + H(+); Xref=Rhea:RHEA:67880, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:59905, ChEBI:CHEBI:133524; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67881; Evidence=; Reaction=3'-phosphoadenylyl sulfate + dopamine = adenosine 3',5'- bisphosphate + dopamine 4-O-sulfate + H(+); Xref=Rhea:RHEA:67884, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:59905, ChEBI:CHEBI:133529; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67885; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 4-ethylphenol = 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:70607, ChEBI:CHEBI:15378, ChEBI:CHEBI:49584, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:133681; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70608; Evidence=; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QWG7-1; Sequence=Displayed; Name=2; IsoId=Q9QWG7-2; Sequence=VSP_012509; Liver specific. Expression was detected at very low level in liver from 1 day-old and then gradually increased to the maximum level at 4 weeks old. Belongs to the sulfotransferase 1 family. aryl sulfotransferase activity cytoplasm cytosol ethanol catabolic process lipid metabolic process xenobiotic metabolic process sulfotransferase activity steroid metabolic process flavonoid metabolic process transferase activity phenol-containing compound metabolic process epithelial cell differentiation thyroid hormone metabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process sulfation uc008xyn.1 uc008xyn.2 
ENSMUST00000031201.9 Sult1e1 ENSMUST00000031201.9 sulfotransferase family 1E, member 1 (from RefSeq NM_023135.2) ENSMUST00000031201.1 ENSMUST00000031201.2 ENSMUST00000031201.3 ENSMUST00000031201.4 ENSMUST00000031201.5 ENSMUST00000031201.6 ENSMUST00000031201.7 ENSMUST00000031201.8 NM_023135 Q9D566 Q9D566_MOUSE Sult1e1 uc008xyp.1 uc008xyp.2 uc008xyp.3 uc008xyp.4 Homodimer. Belongs to the sulfotransferase 1 family. sulfotransferase activity transferase activity uc008xyp.1 uc008xyp.2 uc008xyp.3 uc008xyp.4 
ENSMUST00000031211.6 Smr3a ENSMUST00000031211.6 submaxillary gland androgen regulated protein 3A (from RefSeq NM_011422.4) B7ZP11 ENSMUST00000031211.1 ENSMUST00000031211.2 ENSMUST00000031211.3 ENSMUST00000031211.4 ENSMUST00000031211.5 Msg1 NM_011422 Q61900 SMR3A_MOUSE Smr1 uc012dxy.1 uc012dxy.2 uc012dxy.3 May play a role in protection or detoxification. Secreted. Secreted into saliva by submaxillary gland. Belongs to the PROL1/PROL3 family. endopeptidase inhibitor activity extracellular region negative regulation of endopeptidase activity regulation of sensory perception of pain uc012dxy.1 uc012dxy.2 uc012dxy.3 
ENSMUST00000031215.15 Brdt ENSMUST00000031215.15 bromodomain, testis-specific, transcript variant 1 (from RefSeq NM_054054.2) BRDT_MOUSE ENSMUST00000031215.1 ENSMUST00000031215.10 ENSMUST00000031215.11 ENSMUST00000031215.12 ENSMUST00000031215.13 ENSMUST00000031215.14 ENSMUST00000031215.2 ENSMUST00000031215.3 ENSMUST00000031215.4 ENSMUST00000031215.5 ENSMUST00000031215.6 ENSMUST00000031215.7 ENSMUST00000031215.8 ENSMUST00000031215.9 Fsrg3 G3X8Z8 NM_054054 Q59HJ4 Q91Y44 uc008ymc.1 uc008ymc.2 uc008ymc.3 The protein encoded by this gene belongs to the BET protein family. BET proteins have two N-terminal bromodomains and one C-terminal extraterminal domain (ET domain). BET proteins regulate chromatin reorganization via binding to acetylated histones. This gene is thought to play a role in the transcriptional regulation of spermatogenesis. Although referred to as testis-specific bromodomain (Brdt) protein, RT-PCR indicates that this gene is expressed in both mouse oocytes and testes. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]. Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:12861021, PubMed:19794495, PubMed:22901802, PubMed:22922464). Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed:22901802). Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (PubMed:27105113). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (PubMed:22570411). Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin (PubMed:22020252). Interacts with SMARCE1 (By similarity). Interacts with mRNA splicing machinery proteins SRSF2, DDX5, HNRNPK and TARDBP. Interacts with the acetylated N-terminus of histone H1, H2, H3 and H4. Interacts with P-TEFb components CDK9 and CCNT1/cyclin-T1. Q91Y44; Q9QWV9: Ccnt1; NbExp=2; IntAct=EBI-6260929, EBI-2655009; Q91Y44; Q99J95: Cdk9; NbExp=3; IntAct=EBI-6260929, EBI-2654963; Nucleus Note=Detected on chromatin (PubMed:19794495). Excluded from the chromocenter. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91Y44-1; Sequence=Displayed; Name=2; IsoId=Q91Y44-2; Sequence=VSP_019119, VSP_019120; Testis-specific. Expressed in germinal cells from the early meiotic (pachytene) spermatocytes and during spermiogenesis in the round and elongating spermatids until the condensed late spermatids. No expression seen in spermatogonia. First detected when type B spermatogonia give rise to early meiotic cells (preleptotene, leptotene and zygotene) at 10-12 days post partum (dpp), producing a clearly detectable protein at 12 dpp (at protein level). Bromo domains mediate interaction with histones that have acetylated lysine residues at specific positions. Bromo domain 1 mediates binding with histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) (PubMed:19794495). The bromo domains also recognize and bind a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (PubMed:27105113). Mice are viable but males are sterile, producing fewer and morphologically abnormal sperm. Aberrant morphogenesis are first detected in step 9 elongating spermatids, and those elongated spermatids that are formed lack the distinctive foci of heterochromatin at the peri-nuclear envelope. Spermatid nuclei show a fragmented chromocenter. Brdt is a promising target for male contraception. Inhibition by thienodiazepine inhibitor (+)-JQ1 that binds Asn-108, prevents recognition of acetylated histone H4. Treatment of mice with JQ1 reduces seminiferous tubule area, testis size and spermatozoa number and motility without affecting hormone levels. JQ1 causes a complete and reversible contraceptive effect in male mice (PubMed:22901802). Name=Protein Spotlight; Note=Asking life to be patient - Issue 144 of November 2012; URL="https://web.expasy.org/spotlight/back_issues/144"; histone displacement protein binding nucleus chromatin organization chromatin remodeling regulation of transcription, DNA-templated mRNA processing male meiosis male meiosis I spermatogenesis RNA splicing cell differentiation histone binding regulation of RNA splicing positive regulation of transcription involved in meiotic cell cycle meiotic cell cycle lysine-acetylated histone binding uc008ymc.1 uc008ymc.2 uc008ymc.3 
ENSMUST00000031221.12 Cdc7 ENSMUST00000031221.12 cell division cycle 7, transcript variant 2 (from RefSeq NM_009863.4) CDC7_MOUSE Cdc7l1 ENSMUST00000031221.1 ENSMUST00000031221.10 ENSMUST00000031221.11 ENSMUST00000031221.2 ENSMUST00000031221.3 ENSMUST00000031221.4 ENSMUST00000031221.5 ENSMUST00000031221.6 ENSMUST00000031221.7 ENSMUST00000031221.8 ENSMUST00000031221.9 NM_009863 Q9WUV1 Q9Z0H0 Q9Z2Y7 uc008ylw.1 uc008ylw.2 uc008ylw.3 uc008ylw.4 Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity. Interacts with CLASPIN (via the acidic patch); the interaction is required for phosphorylation of MCM proteins and CLASPIN. Nucleus Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9Z0H0-1; Sequence=Displayed; Name=2; IsoId=Q9Z0H0-2; Sequence=VSP_004864; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily. nucleotide binding double-strand break repair via break-induced replication protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleoplasm cytoplasm protein phosphorylation cell cycle positive regulation of cell proliferation positive regulation of nuclear cell cycle DNA replication positive regulation of G2/M transition of mitotic cell cycle kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation cell cycle phase transition intercellular bridge metal ion binding cell division mitotic spindle uc008ylw.1 uc008ylw.2 uc008ylw.3 uc008ylw.4 
ENSMUST00000031224.15 Tgfbr3 ENSMUST00000031224.15 transforming growth factor, beta receptor III (from RefSeq NM_011578.4) A0A0R4J097 A0A0R4J097_MOUSE ENSMUST00000031224.1 ENSMUST00000031224.10 ENSMUST00000031224.11 ENSMUST00000031224.12 ENSMUST00000031224.13 ENSMUST00000031224.14 ENSMUST00000031224.2 ENSMUST00000031224.3 ENSMUST00000031224.4 ENSMUST00000031224.5 ENSMUST00000031224.6 ENSMUST00000031224.7 ENSMUST00000031224.8 ENSMUST00000031224.9 NM_011578 Tgfbr3 uc008ylz.1 uc008ylz.2 uc008ylz.3 uc008ylz.4 response to hypoxia epithelial to mesenchymal transition transforming growth factor beta-activated receptor activity type II transforming growth factor beta receptor binding transforming growth factor beta receptor binding extracellular region extracellular space cytoplasm integral component of plasma membrane immune response transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor complex assembly heparin binding external side of plasma membrane coreceptor activity membrane integral component of membrane fibroblast growth factor binding BMP signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway extracellular matrix animal organ regeneration response to follicle-stimulating hormone inhibin-betaglycan-ActRII complex response to prostaglandin E response to luteinizing hormone intracellular signal transduction receptor complex regulation of protein binding SMAD binding activin binding transforming growth factor beta binding negative regulation of cellular component movement cardiac epithelial to mesenchymal transition pathway-restricted SMAD protein phosphorylation macromolecular complex assembly transforming growth factor beta receptor activity, type III uc008ylz.1 uc008ylz.2 uc008ylz.3 uc008ylz.4 
ENSMUST00000031227.11 Zfp326 ENSMUST00000031227.11 zinc finger protein 326, transcript variant 1 (from RefSeq NM_018759.2) A0A0R4J098 A0A0R4J098_MOUSE ENSMUST00000031227.1 ENSMUST00000031227.10 ENSMUST00000031227.2 ENSMUST00000031227.3 ENSMUST00000031227.4 ENSMUST00000031227.5 ENSMUST00000031227.6 ENSMUST00000031227.7 ENSMUST00000031227.8 ENSMUST00000031227.9 NM_018759 Zfp326 uc008ylj.1 uc008ylj.2 uc008ylj.3 uc008ylj.4 uc008ylj.5 Belongs to the AKAP95 family. RNA polymerase II core binding DNA binding nucleus nucleoplasm regulation of DNA-templated transcription, elongation intracellular membrane-bounded organelle regulation of RNA splicing DBIRD complex uc008ylj.1 uc008ylj.2 uc008ylj.3 uc008ylj.4 uc008ylj.5 
ENSMUST00000031235.13 Gbp8 ENSMUST00000031235.13 guanylate-binding protein 8 (from RefSeq NM_029509.4) ENSMUST00000031235.1 ENSMUST00000031235.10 ENSMUST00000031235.11 ENSMUST00000031235.12 ENSMUST00000031235.2 ENSMUST00000031235.3 ENSMUST00000031235.4 ENSMUST00000031235.5 ENSMUST00000031235.6 ENSMUST00000031235.7 ENSMUST00000031235.8 ENSMUST00000031235.9 F7CE50 Gbp8 NM_029509 Q2V6D6 Q2V6D6_MOUSE mGBP8 uc290xrv.1 uc290xrv.2 Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. nucleotide binding GTPase activity GTP binding symbiont-containing vacuole membrane cytoplasmic vesicle defense response to protozoan defense response to Gram-positive bacterium cellular response to interferon-gamma uc290xrv.1 uc290xrv.2 
ENSMUST00000031239.13 Abcg3 ENSMUST00000031239.13 ATP binding cassette subfamily G member 3, transcript variant 1 (from RefSeq NM_030239.3) ABCG3_MOUSE ENSMUST00000031239.1 ENSMUST00000031239.10 ENSMUST00000031239.11 ENSMUST00000031239.12 ENSMUST00000031239.2 ENSMUST00000031239.3 ENSMUST00000031239.4 ENSMUST00000031239.5 ENSMUST00000031239.6 ENSMUST00000031239.7 ENSMUST00000031239.8 ENSMUST00000031239.9 NM_030239 Q8BKI5 Q99P81 uc008ykt.1 uc008ykt.2 uc008ykt.3 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It lacks several highly conserved residues found in other ATP-binding proteins; this suggests that this protein may not bind ATP and may require dimerization with another subunit to form a functional ATP-transporter. The function of this gene has not yet been determined; however, high levels of expression in the thymus and spleen suggest a potential role in the transport of specific peptides or hydrophobic compounds from lymphocytes. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AK051880.1, AK030831.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## May dimerize with another subunit to form a functional transporter. Membrane ; Multi-pass membrane protein Highest levels of expression in thymus and spleen. Detected in lung and small intestine. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. Seems to have a defective ATP-binding region. ATP binding plasma membrane membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances transmembrane transport uc008ykt.1 uc008ykt.2 uc008ykt.3 
ENSMUST00000031243.15 Spp1 ENSMUST00000031243.15 secreted phosphoprotein 1, transcript variant 4 (from RefSeq NM_009263.3) ENSMUST00000031243.1 ENSMUST00000031243.10 ENSMUST00000031243.11 ENSMUST00000031243.12 ENSMUST00000031243.13 ENSMUST00000031243.14 ENSMUST00000031243.2 ENSMUST00000031243.3 ENSMUST00000031243.4 ENSMUST00000031243.5 ENSMUST00000031243.6 ENSMUST00000031243.7 ENSMUST00000031243.8 ENSMUST00000031243.9 NM_009263 OPN Q547B5 Q547B5_MOUSE Spp1 uc008yki.1 uc008yki.2 uc008yki.3 uc008yki.4 Secreted Belongs to the osteopontin family. ossification cell adhesion uc008yki.1 uc008yki.2 uc008yki.3 uc008yki.4 
ENSMUST00000031246.9 Ibsp ENSMUST00000031246.9 integrin binding sialoprotein (from RefSeq NM_008318.3) ENSMUST00000031246.1 ENSMUST00000031246.2 ENSMUST00000031246.3 ENSMUST00000031246.4 ENSMUST00000031246.5 ENSMUST00000031246.6 ENSMUST00000031246.7 ENSMUST00000031246.8 NM_008318 Q61363 Q61711 Q80VR6 SIAL_MOUSE uc008ykg.1 uc008ykg.2 uc008ykg.3 uc008ykg.4 Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity). Secreted. N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains. Sulfated on either Tyr-320 or Tyr-321. It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite. ossification integrin binding extracellular region extracellular space cell adhesion extracellular matrix organization bone mineralization biomineral tissue development vesicle positive regulation of cell adhesion cellular response to growth factor stimulus uc008ykg.1 uc008ykg.2 uc008ykg.3 uc008ykg.4 
ENSMUST00000031249.8 Sparcl1 ENSMUST00000031249.8 SPARC-like 1, transcript variant 3 (from RefSeq NM_010097.4) E9QPH2 ENSMUST00000031249.1 ENSMUST00000031249.2 ENSMUST00000031249.3 ENSMUST00000031249.4 ENSMUST00000031249.5 ENSMUST00000031249.6 ENSMUST00000031249.7 Ecm2 NM_010097 P70663 P97810 Q99L82 SPRL1_MOUSE Sc1 uc008ykb.1 uc008ykb.2 uc008ykb.3 uc008ykb.4 uc008ykb.5 Secreted, extracellular space, extracellular matrix. Highest expression in brain. Moderate levels in heart, adrenal gland, epididymis and lung. Low levels in kidney, eye, liver, spleen, submandibular gland and testis. Belongs to the SPARC family. calcium ion binding collagen binding extracellular region extracellular space signal transduction synapse metal ion binding regulation of synapse organization extracellular matrix binding extracellular matrix of synaptic cleft glutamatergic synapse synaptic membrane adhesion uc008ykb.1 uc008ykb.2 uc008ykb.3 uc008ykb.4 uc008ykb.5 
ENSMUST00000031250.14 Nudt9 ENSMUST00000031250.14 nudix hydrolase 9 (from RefSeq NM_028794.4) A2AH31 ENSMUST00000031250.1 ENSMUST00000031250.10 ENSMUST00000031250.11 ENSMUST00000031250.12 ENSMUST00000031250.13 ENSMUST00000031250.2 ENSMUST00000031250.3 ENSMUST00000031250.4 ENSMUST00000031250.5 ENSMUST00000031250.6 ENSMUST00000031250.7 ENSMUST00000031250.8 ENSMUST00000031250.9 NM_028794 NUDT9_MOUSE Q3TZ68 Q8BVU5 Q8K1J4 uc008yka.1 uc008yka.2 uc008yka.3 uc008yka.4 Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. Reaction=ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+); Xref=Rhea:RHEA:10412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57967, ChEBI:CHEBI:78346, ChEBI:CHEBI:456215; EC=3.6.1.13; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Monomer. Interacts with GLOD4. Mitochondrion Belongs to the Nudix hydrolase family. NudF subfamily. mitochondrion hydrolase activity adenosine-diphosphatase activity ADP catabolic process IDP catabolic process ADP-ribose diphosphatase activity uc008yka.1 uc008yka.2 uc008yka.3 uc008yka.4 
ENSMUST00000031251.16 Hsd17b11 ENSMUST00000031251.16 hydroxysteroid (17-beta) dehydrogenase 11 (from RefSeq NM_053262.3) DHB11_MOUSE Dhrs8 ENSMUST00000031251.1 ENSMUST00000031251.10 ENSMUST00000031251.11 ENSMUST00000031251.12 ENSMUST00000031251.13 ENSMUST00000031251.14 ENSMUST00000031251.15 ENSMUST00000031251.2 ENSMUST00000031251.3 ENSMUST00000031251.4 ENSMUST00000031251.5 ENSMUST00000031251.6 ENSMUST00000031251.7 ENSMUST00000031251.8 ENSMUST00000031251.9 NM_053262 Pan1b Q3U2P6 Q8BR33 Q8C7S0 Q9EQ06 uc008yjy.1 uc008yjy.2 uc008yjy.3 Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A- dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence=; Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH; Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62; Evidence=; Endoplasmic reticulum Lipid droplet Note=Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EQ06-1; Sequence=Displayed; Name=2; IsoId=Q9EQ06-2; Sequence=VSP_015013, VSP_015014; Expressed in the liver (at protein level) (PubMed:18359291). Also expressed in the intestine and, at much lower levels, in the kidney (PubMed:18359291). Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. estradiol 17-beta-dehydrogenase activity cytoplasm endoplasmic reticulum lipid particle lipid metabolic process steroid biosynthetic process androgen catabolic process steroid dehydrogenase activity oxidoreductase activity oxidation-reduction process uc008yjy.1 uc008yjy.2 uc008yjy.3 
ENSMUST00000031254.9 Klhl8 ENSMUST00000031254.9 kelch-like 8, transcript variant 2 (from RefSeq NM_178741.4) ENSMUST00000031254.1 ENSMUST00000031254.2 ENSMUST00000031254.3 ENSMUST00000031254.4 ENSMUST00000031254.5 ENSMUST00000031254.6 ENSMUST00000031254.7 ENSMUST00000031254.8 KLHL8_MOUSE NM_178741 P59280 Q8CD84 uc008yjv.1 uc008yjv.2 uc008yjv.3 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN. Protein modification; protein ubiquitination. Component of the BCR(KLHL8) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL8 and RBX1. Interacts with RAPSN (By similarity). nucleoplasm ubiquitin-dependent protein catabolic process protein ubiquitination Cul3-RING ubiquitin ligase complex uc008yjv.1 uc008yjv.2 uc008yjv.3 
ENSMUST00000031262.9 Coq2 ENSMUST00000031262.9 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase (from RefSeq NM_027978.2) COQ2_MOUSE Coq2 E9QPH1 ENSMUST00000031262.1 ENSMUST00000031262.2 ENSMUST00000031262.3 ENSMUST00000031262.4 ENSMUST00000031262.5 ENSMUST00000031262.6 ENSMUST00000031262.7 ENSMUST00000031262.8 NM_027978 Q66JT7 Q9D7M9 uc008yhu.1 uc008yhu.2 uc008yhu.3 uc008yhu.4 Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis (PubMed:20526342). Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-trans-nonaprenyl diphosphate) (PubMed:20526342). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9 (PubMed:20526342). However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10 (By similarity). Plays a central role in the biosynthesis of CoQ9 (PubMed:20526342). CoQ9 is a vital molecule that transports electrons from mitochondrial respiratory chain complexes (PubMed:20526342). CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide-dependent apoptotic pathway (By similarity). Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner (By similarity). Reaction=4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4- hydroxy-3-all-trans-polyprenylbenzoate + diphosphate; Xref=Rhea:RHEA:44504, Rhea:RHEA-COMP:9514, Rhea:RHEA-COMP:9564, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:58914, ChEBI:CHEBI:78396; EC=2.5.1.39; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44505; Evidence=; Reaction=4-hydroxybenzoate + all-trans-decaprenyl diphosphate = 4- hydroxy-3-all-trans-decaprenylbenzoate + diphosphate; Xref=Rhea:RHEA:44564, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:60721, ChEBI:CHEBI:84503; EC=2.5.1.39; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44565; Evidence=; Reaction=4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4- hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate; Xref=Rhea:RHEA:17709, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:58391, ChEBI:CHEBI:84502; EC=2.5.1.39; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17710; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cofactor biosynthesis; ubiquinone biosynthesis. Mitochondrion inner membrane ulti-pass membrane protein atrix side Belongs to the UbiA prenyltransferase family. Sequence=BAB26064.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; 4-hydroxybenzoate decaprenyltransferase activity polyprenyltransferase activity prenyltransferase activity mitochondrion mitochondrial inner membrane glycerol metabolic process ubiquinone biosynthetic process isoprenoid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups integral component of mitochondrial inner membrane 4-hydroxybenzoate nonaprenyltransferase activity uc008yhu.1 uc008yhu.2 uc008yhu.3 uc008yhu.4 
ENSMUST00000031263.2 Slc10a6 ENSMUST00000031263.2 solute carrier family 10 (sodium/bile acid cotransporter family), member 6 (from RefSeq NM_029415.3) B2RTH4 ENSMUST00000031263.1 NM_029415 Q9CXB2 SOAT_MOUSE Soat uc008yjp.1 uc008yjp.2 Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis (PubMed:23562556). Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids (By similarity). May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs (PubMed:23562556). May play a role transporting the estriol precursor 16alpha- hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium (By similarity). Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes (By similarity). Reaction=estrone 3-sulfate(out) + 2 Na(+)(out) = estrone 3-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71083, ChEBI:CHEBI:29101, ChEBI:CHEBI:60050; Evidence=; Reaction=17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) = 17beta- estradiol 3-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71087, ChEBI:CHEBI:29101, ChEBI:CHEBI:136582; Evidence=; Reaction=dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71091, ChEBI:CHEBI:29101, ChEBI:CHEBI:57905; Evidence=; Reaction=androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) = androst-5- ene-diol 3-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71099, ChEBI:CHEBI:29101, ChEBI:CHEBI:190287; Evidence=; Reaction=2 Na(+)(out) + pregnenolone sulfate(out) = 2 Na(+)(in) + pregnenolone sulfate(in); Xref=Rhea:RHEA:71095, ChEBI:CHEBI:29101, ChEBI:CHEBI:133000; Evidence=; Reaction=2 Na(+)(out) + taurolithocholate 3-sulfate(out) = 2 Na(+)(in) + taurolithocholate 3-sulfate(in); Xref=Rhea:RHEA:71275, ChEBI:CHEBI:29101, ChEBI:CHEBI:58301; Evidence=; Reaction=androsterone 3alpha-sulfate(out) + 2 Na(+)(out) = androsterone 3alpha-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71351, ChEBI:CHEBI:29101, ChEBI:CHEBI:133003; Evidence=; Reaction=5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) = 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71355, ChEBI:CHEBI:29101, ChEBI:CHEBI:136982; Evidence=; Reaction=17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) = 17beta- estradiol 17-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71359, ChEBI:CHEBI:29101, ChEBI:CHEBI:190469; Evidence=; Reaction=17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) = 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71363, ChEBI:CHEBI:29101, ChEBI:CHEBI:133742; Evidence=; Reaction=epiandrosterone 3-sulfate(out) + 2 Na(+)(out) = epiandrosterone 3-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71367, ChEBI:CHEBI:29101, ChEBI:CHEBI:133729; Evidence=; Reaction=epitestosterone 17-sulfate(out) + 2 Na(+)(out) = epitestosterone 17-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71371, ChEBI:CHEBI:29101, ChEBI:CHEBI:190485; Evidence=; Reaction=2 Na(+)(out) + testosterone 17-sulfate(out) = 2 Na(+)(in) + testosterone 17-sulfate(in); Xref=Rhea:RHEA:71375, ChEBI:CHEBI:29101, ChEBI:CHEBI:190489; Evidence=; Reaction=16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71391, ChEBI:CHEBI:29101, ChEBI:CHEBI:87538; Evidence=; Kinetic parameters: KM=60.3 uM for dehydroepiandrosterone 3-sulfate (DHEAS) ; KM=2.1 uM for estrone 3-sulfate (E1S) ; KM=2.5 uM for pregnenolone sulfate (PREGS) ; Vmax=362.8 pmol/min/mg enzyme with dehydroepiandrosterone 3-sulfate (DHEAS) as substrate ; Vmax=26.6 pmol/min/mg enzyme with estrone 3-sulfate (E1S) as substrate ; Vmax=377.3 pmol/min/mg enzyme with pregnenolone sulfate (PREGS) as substrate ; Membrane ; Multi- pass membrane protein Highest expression in lung and testis, moderate expression in heart, bladder and skin, and low expression in blood, liver, stomach, small intestine, spleen, kidney, adrenal gland, seminal vesicle, preputial gland, coagulating gland, lacrimal gland/eye, and brain. Glycosylated. Knockout mice have normal reproductive phenotype, however, males show higher cholesterol sulfate serum levels than wild- type. In humans, 3-beta-sulfooxy-androst-5-en-17-one (DHEAS) is the most abundant circulating steroid sulfate in the human body, it is mainly synthesized from adrenal glands and gonads, whereas rats and mice have low circulating concentrations of DHEAS in the periphery as they can only produce DHEAS in their gonads. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. plasma membrane ion transport sodium ion transport bile acid:sodium symporter activity symporter activity bile acid and bile salt transport membrane integral component of membrane sodium-dependent organic anion transmembrane transporter activity sodium-dependent organic anion transport transmembrane transport uc008yjp.1 uc008yjp.2 
ENSMUST00000031264.12 Plac8 ENSMUST00000031264.12 placenta-specific 8, transcript variant 2 (from RefSeq NM_139198.3) ENSMUST00000031264.1 ENSMUST00000031264.10 ENSMUST00000031264.11 ENSMUST00000031264.2 ENSMUST00000031264.3 ENSMUST00000031264.4 ENSMUST00000031264.5 ENSMUST00000031264.6 ENSMUST00000031264.7 ENSMUST00000031264.8 ENSMUST00000031264.9 NM_139198 PLAC8_MOUSE Q9JI48 uc008yht.1 uc008yht.2 uc008yht.3 Belongs to the cornifelin family. chromatin binding protein binding nucleus positive regulation of cell proliferation response to cold negative regulation of multicellular organism growth defense response to bacterium negative regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter brown fat cell differentiation uc008yht.1 uc008yht.2 uc008yht.3 
ENSMUST00000031273.9 Cds1 ENSMUST00000031273.9 CDP-diacylglycerol synthase 1, transcript variant 1 (from RefSeq NM_173370.4) CDS1_MOUSE Cds Cds1 ENSMUST00000031273.1 ENSMUST00000031273.2 ENSMUST00000031273.3 ENSMUST00000031273.4 ENSMUST00000031273.5 ENSMUST00000031273.6 ENSMUST00000031273.7 ENSMUST00000031273.8 NM_173370 P98191 Q8CGZ1 uc008yio.1 uc008yio.2 uc008yio.3 Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (By similarity). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (By similarity). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540). Positively regulates the differentiation and development of adipocytes (PubMed:26946540). Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2- diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16230; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45648, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77091, ChEBI:CHEBI:85349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45649; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)- sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45660, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77098, ChEBI:CHEBI:85352; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45661; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45652, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:72864, ChEBI:CHEBI:85350; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45653; Evidence=; Reaction=1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3- cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45656, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77126, ChEBI:CHEBI:85351; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45657; Evidence=; Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45664, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:74560, ChEBI:CHEBI:85353; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45665; Evidence=; Reaction=1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2- (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'- diphosphate + diphosphate; Xref=Rhea:RHEA:45668, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77130, ChEBI:CHEBI:85354; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45669; Evidence=; Reaction=1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'- diphosphate + diphosphate; Xref=Rhea:RHEA:45672, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77128, ChEBI:CHEBI:85355; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45673; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45676, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:74546, ChEBI:CHEBI:85356; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45677; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 3/3. Homodimer (By similarity). Interacts with FOS; this interaction may enhance catalytic activity (PubMed:22105363). Endoplasmic reticulum membrane ; Multi-pass membrane protein Expressed in adult brain, eye, smooth muscle and testis. Highly expressed in the inner segment of the photoreceptor layer of adult retina. Expressed in a structure probably corresponding to the thymic rudiment 12.5 dpc. No expression could be detected at earlier and later stages of embryonic development (10.5 dpc and 17.5 dpc). Belongs to the CDS family. phosphatidate cytidylyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phosphatidylinositol biosynthetic process phospholipid biosynthetic process membrane integral component of membrane CDP-diacylglycerol biosynthetic process transferase activity transferase activity, transferring phosphorus-containing groups nucleotidyltransferase activity uc008yio.1 uc008yio.2 uc008yio.3 
ENSMUST00000031276.15 Rasgef1b ENSMUST00000031276.15 RasGEF domain family, member 1B, transcript variant 1 (from RefSeq NM_145839.2) ENSMUST00000031276.1 ENSMUST00000031276.10 ENSMUST00000031276.11 ENSMUST00000031276.12 ENSMUST00000031276.13 ENSMUST00000031276.14 ENSMUST00000031276.2 ENSMUST00000031276.3 ENSMUST00000031276.4 ENSMUST00000031276.5 ENSMUST00000031276.6 ENSMUST00000031276.7 ENSMUST00000031276.8 ENSMUST00000031276.9 F5H8M5 Gpig4 NM_145839 Q3UE12 Q8C189 Q8JZL7 RGF1B_MOUSE uc008ygl.1 uc008ygl.2 uc008ygl.3 Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro). Interacts with CCDC124 during cytokinesis (By similarity). Interacts with Ras family proteins. Early endosome Late endosome Midbody Note=Localizes to midbody at telophase (By similarity). May shuttle between early and late endosomes. Does not colocalize with lysosomal markers. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8JZL7-1; Sequence=Displayed; Name=2; IsoId=Q8JZL7-2; Sequence=VSP_027315; Name=3; IsoId=Q8JZL7-3; Sequence=VSP_059002, VSP_059003; Constitutively expressed in brain, intestine and testis. Low constitutive expression, if any, in heart, lung, lymph nodes and thymus. Up-regulated in heart, kidney, liver, lymph nodes, spleen and thymus at day 20 after infection with Trypanosoma cruzi. Not detected in muscle. In vitro, up-regulated in peritoneal macrophages by GPI- mucins, bacterial lipopolysaccharides (LPS) and poly(I:C). Small induction, if any, by IFNG alone. Induction is maximal 12 and 18 hours following LPS stimulation (at protein level). Also induced in T-helper cells activated by phytohemagglutinin. In vivo, up-regulated by infection with protozoan parasites, including Plasmodium chabaudi and Trypanosoma cruzi. This induction is dependent upon IFNG, MYD88 and TICAM1. [Isoform 3]: Sequence=AK048739; Type=Frameshift; Evidence=; guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity endosome early endosome late endosome small GTPase mediated signal transduction midbody uc008ygl.1 uc008ygl.2 uc008ygl.3 
ENSMUST00000031278.6 Bmp3 ENSMUST00000031278.6 bone morphogenetic protein 3, transcript variant 2 (from RefSeq NM_173404.5) BMP3_MOUSE ENSMUST00000031278.1 ENSMUST00000031278.2 ENSMUST00000031278.3 ENSMUST00000031278.4 ENSMUST00000031278.5 NM_173404 Q8BHE5 uc008ygh.1 uc008ygh.2 uc008ygh.3 uc008ygh.4 uc008ygh.5 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. Homozygous knockout mice for this gene exhibit increased bone density and volume, while overexpression of this gene in a transgenic mouse causes bone defects resulting in spontaneous rib fractures. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016]. Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification. Homodimer; disulfide-linked. Secreted. Adult mice lacking BMP3 have increased bone mass (PubMed:11138004). Targeted loss of BMP3 results also in increased differentiation of early osteoblasts precursors into mature osteoblasts and further supports a role of BMP3 in regulating adult bone mass (PubMed:22074949). Belongs to the TGF-beta family. ossification osteoblast differentiation cytokine activity transforming growth factor beta receptor binding extracellular region extracellular space multicellular organism development growth factor activity positive regulation of pathway-restricted SMAD protein phosphorylation cell differentiation BMP signaling pathway vesicle regulation of apoptotic process regulation of MAPK cascade positive regulation of transcription from RNA polymerase II promoter cell development cartilage development SMAD protein signal transduction BMP receptor binding uc008ygh.1 uc008ygh.2 uc008ygh.3 uc008ygh.4 uc008ygh.5 
ENSMUST00000031280.2 Fgf5 ENSMUST00000031280.2 fibroblast growth factor 5, transcript variant 1 (from RefSeq NM_010203.6) ENSMUST00000031280.1 FGF5_MOUSE Fgf-5 NM_010203 O88825 P15656 uc008ygc.1 uc008ygc.2 uc008ygc.3 uc008ygc.4 This gene encodes a secreted protein that is a member of a family of heparin-binding growth factors. The encoded protein regulates cell proliferation, particularly the growth of hair follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity). Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity). Secreted Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P15656-1; Sequence=Displayed; Name=Short; Synonyms=FGF-5S; IsoId=P15656-2; Sequence=VSP_001520, VSP_001521; [Isoform Short]: Seems to have an antagonistic effect compared to that of the isoform Long. Belongs to the heparin-binding growth factors family. fibroblast growth factor receptor binding extracellular region growth factor activity cell proliferation positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway glial cell differentiation signal transduction involved in regulation of gene expression positive regulation of cell division uc008ygc.1 uc008ygc.2 uc008ygc.3 uc008ygc.4 
ENSMUST00000031281.14 Antxr2 ENSMUST00000031281.14 anthrax toxin receptor 2 (from RefSeq NM_133738.3) ANTR2_MOUSE ENSMUST00000031281.1 ENSMUST00000031281.10 ENSMUST00000031281.11 ENSMUST00000031281.12 ENSMUST00000031281.13 ENSMUST00000031281.2 ENSMUST00000031281.3 ENSMUST00000031281.4 ENSMUST00000031281.5 ENSMUST00000031281.6 ENSMUST00000031281.7 ENSMUST00000031281.8 ENSMUST00000031281.9 NM_133738 Q6DFX2 Q99L17 uc008yga.1 uc008yga.2 uc008yga.3 Necessary for cellular interactions with laminin and the extracellular matrix. Binds laminin, and possibly also collagen type IV. Membrane ; Single- pass type I membrane protein Belongs to the ATR family. transmembrane signaling receptor activity plasma membrane external side of plasma membrane cell surface membrane integral component of membrane reproductive process signaling receptor activity metal ion binding toxin transport uc008yga.1 uc008yga.2 uc008yga.3 
ENSMUST00000031286.13 Crybb1 ENSMUST00000031286.13 crystallin, beta B1, transcript variant 2 (from RefSeq NM_023695.3) CRBB1_MOUSE ENSMUST00000031286.1 ENSMUST00000031286.10 ENSMUST00000031286.11 ENSMUST00000031286.12 ENSMUST00000031286.2 ENSMUST00000031286.3 ENSMUST00000031286.4 ENSMUST00000031286.5 ENSMUST00000031286.6 ENSMUST00000031286.7 ENSMUST00000031286.8 ENSMUST00000031286.9 NM_023695 Q9WVJ5 uc008ysv.1 uc008ysv.2 uc008ysv.3 uc008ysv.4 This gene encodes a member of the crystallin family of proteins that contribute to the transparency and refractive properties of the ocular lens. The encoded protein associates with other beta crystallin proteins to form dimers, tetramers and other higher-order complexes. This gene is located adjacent to a related crystallin gene on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. Crystallins are the dominant structural components of the vertebrate eye lens. Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. Q9WVJ5; P23928: Cryab; Xeno; NbExp=2; IntAct=EBI-8520354, EBI-916888; Has a two-domain beta-structure, folded into four very similar Greek key motifs. Specific cleavages in the N-terminal arm occur during lens maturation and give rise to truncated forms, leading to impaired oligomerization and protein insolubilization. The protease responsible for this partial degradation could be calpain II. Belongs to the beta/gamma-crystallin family. lens development in camera-type eye structural constituent of eye lens protein binding visual perception uc008ysv.1 uc008ysv.2 uc008ysv.3 uc008ysv.4 
ENSMUST00000031287.12 Tpst2 ENSMUST00000031287.12 protein-tyrosine sulfotransferase 2, transcript variant 1 (from RefSeq NM_009419.5) ENSMUST00000031287.1 ENSMUST00000031287.10 ENSMUST00000031287.11 ENSMUST00000031287.2 ENSMUST00000031287.3 ENSMUST00000031287.4 ENSMUST00000031287.5 ENSMUST00000031287.6 ENSMUST00000031287.7 ENSMUST00000031287.8 ENSMUST00000031287.9 NM_009419 Q3TQN1 Q3TQN1_MOUSE Tpst2 uc008ysx.1 uc008ysx.2 uc008ysx.3 uc008ysx.4 Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. Reaction=3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]; Xref=Rhea:RHEA:16801, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:11688, ChEBI:CHEBI:15378, ChEBI:CHEBI:46858, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:65286; EC=2.8.2.20; Evidence= Golgi apparatus membrane ; Single-pass type II membrane protein Belongs to the protein sulfotransferase family. endoplasmic reticulum peptidyl-tyrosine sulfation protein-tyrosine sulfotransferase activity transferase activity protein homodimerization activity uc008ysx.1 uc008ysx.2 uc008ysx.3 uc008ysx.4 
ENSMUST00000031288.14 Tfip11 ENSMUST00000031288.14 tuftelin interacting protein 11 (from RefSeq NM_018783.4) ENSMUST00000031288.1 ENSMUST00000031288.10 ENSMUST00000031288.11 ENSMUST00000031288.12 ENSMUST00000031288.13 ENSMUST00000031288.2 ENSMUST00000031288.3 ENSMUST00000031288.4 ENSMUST00000031288.5 ENSMUST00000031288.6 ENSMUST00000031288.7 ENSMUST00000031288.8 ENSMUST00000031288.9 NM_018783 Q8VD06 Q9ERA6 Stip TFP11_MOUSE Tip39 uc008ysy.1 uc008ysy.2 uc008ysy.3 Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2. Q9ERA6; O35286: Dhx15; NbExp=3; IntAct=EBI-8338752, EBI-8322087; Cytoplasm. Nucleus. Note=In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles. Widely expressed. In tooth it is expressed in ameloblasts and odontoblasts. Expressed as early as 14 dpc and continues into postnatal development. Within the developing tooth, expression is localized at the apical region of the ameloblast cells and to the apical regions of the newly formed enamel matrix. Belongs to the TFP11/STIP family. spliceosomal complex disassembly nuclear chromosome, telomeric region nucleic acid binding protein binding nucleus spliceosomal complex nucleolus cytoplasm mRNA processing RNA splicing nuclear speck cell differentiation extracellular matrix organization extracellular matrix biomineral tissue development negative regulation of protein complex assembly negative regulation of protein binding U2-type post-mRNA release spliceosomal complex catalytic step 2 spliceosome uc008ysy.1 uc008ysy.2 uc008ysy.3 
ENSMUST00000031289.7 Srrd ENSMUST00000031289.7 SRR1 domain containing, transcript variant 3 (from RefSeq NR_153105.1) ENSMUST00000031289.1 ENSMUST00000031289.2 ENSMUST00000031289.3 ENSMUST00000031289.4 ENSMUST00000031289.5 ENSMUST00000031289.6 NR_153105 Q08AU8 Q8K2M3 Q9CSK3 SRR1L_MOUSE uc008ysz.1 uc008ysz.2 uc008ysz.3 uc008ysz.4 Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. Cytoplasm Note=Also found in intracellular organelles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2M3-1; Sequence=Displayed; Name=2; IsoId=Q8K2M3-2; Sequence=VSP_038445; Up-regulated by hemin and 5-aminolevulinic acid. Belongs to the SRR1 family. molecular_function nucleus cytoplasm heme biosynthetic process microtubule-based process circadian rhythm regulation of circadian rhythm rhythmic process regulation of heme biosynthetic process uc008ysz.1 uc008ysz.2 uc008ysz.3 uc008ysz.4 
ENSMUST00000031291.9 Asphd2 ENSMUST00000031291.9 aspartate beta-hydroxylase domain containing 2, transcript variant 1 (from RefSeq NM_028386.2) ASPH2_MOUSE ENSMUST00000031291.1 ENSMUST00000031291.2 ENSMUST00000031291.3 ENSMUST00000031291.4 ENSMUST00000031291.5 ENSMUST00000031291.6 ENSMUST00000031291.7 ENSMUST00000031291.8 NM_028386 Q80VP9 Q9CUZ2 uc008yth.1 uc008yth.2 uc008yth.3 uc008yth.4 May function as 2-oxoglutarate-dependent dioxygenase. Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Membrane ; Single-pass type II membrane protein Belongs to the aspartyl/asparaginyl beta-hydroxylase family. molecular_function biological_process membrane integral component of membrane oxidoreductase activity peptidyl-amino acid modification metal ion binding dioxygenase activity oxidation-reduction process uc008yth.1 uc008yth.2 uc008yth.3 uc008yth.4 
ENSMUST00000031304.14 Tesc ENSMUST00000031304.14 tescalcin, transcript variant 2 (from RefSeq NR_151582.1) CHP3_MOUSE Chp3 ENSMUST00000031304.1 ENSMUST00000031304.10 ENSMUST00000031304.11 ENSMUST00000031304.12 ENSMUST00000031304.13 ENSMUST00000031304.2 ENSMUST00000031304.3 ENSMUST00000031304.4 ENSMUST00000031304.5 ENSMUST00000031304.6 ENSMUST00000031304.7 ENSMUST00000031304.8 ENSMUST00000031304.9 NR_151582 Q32Q85 Q8VCN1 Q9JKL5 uc008zgc.1 uc008zgc.2 uc008zgc.3 Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. Monomer (PubMed:14661968). Homodimer; disulfide-linked (PubMed:14661968). Interacts with SLC9A1/NHE1; the interaction enables an optimal Na(+)/H(+) exchange activity (By similarity). Nucleus Cytoplasm Membrane ; Lipid-anchor Cell membrane Cell projection, lamellipodium Cell projection, ruffle membrane Note=Colocalizes with SLC9A1 at the cell membrane. Expressed in embryonic, newborn and adult testis, but not in prepubertal testis. Expressed in the embryonic testis during testis determination but is not expressed at any time in the embryonic ovary. In embryonic testis, expression is restricted to the testis cords and is seen in both Sertoli cells and germ cells. Expression is excluded from the myoid cells which surround the cords. Expressed in the embryonic adrenal after the initial stages of differentiation. Expressed at a lower level in the embryonic brain, heart and lung but not in liver or gut. May be expressed at a very low level in the embryonic kidney. In the embryonic brain, expressed in the nasal placode and in fibers extending from the olfactory epithelium to the primordial olfactory bulb. In adults, expressed in the heart, and weakly in the brain and kidney. Highly expressed in terminally differentiated megakaryocytes (at protein level). Not detected in fetal liver cells (at protein level). Expression is first detected in the male gonad at 11.5 dpc, peaks at 14.5 dpc, declines slightly by 15.5 dpc, and continues to at least 17.5 dpc. Binds calcium via its EF-hands. Calcium-binding mediates a conformational change. Can also bind magnesium. According PubMed:22285131, mice show a normal number of megakaryocytes and platelets. Belongs to the calcineurin regulatory subunit family. CHP subfamily. The region of SLC9A1/NHE1 that interacts with CHP3 is conflicting: In human, interaction with SLC9A1/NHE1 has been reported via residues 507-549, the juxtamembrane region of the cytoplasmic C- terminus. However, another publication has reported interaction with SLC9A1/NHE1 via residues 637-820, the region of the cytoplasmic C- terminus more distal to the membrane. magnesium ion binding ruffle protein kinase inhibitor activity calcium ion binding nucleus cytoplasm cytosol plasma membrane negative regulation of protein kinase activity cellular sodium ion homeostasis negative regulation of cell proliferation male gonad development positive regulation of gene expression protein transport membrane phosphatase inhibitor activity lamellipodium cell differentiation megakaryocyte differentiation positive regulation of granulocyte differentiation positive regulation of sodium:proton antiporter activity ruffle membrane regulation of cell adhesion mediated by integrin protein homodimerization activity cell projection negative regulation of catalytic activity positive regulation of megakaryocyte differentiation positive regulation of transcription, DNA-templated metal ion binding protein stabilization protein maturation cellular response to retinoic acid protein localization to plasma membrane megakaryocyte development uc008zgc.1 uc008zgc.2 uc008zgc.3 
ENSMUST00000031305.4 Gm9754 ENSMUST00000031305.4 predicted gene 9754 (from RefSeq NR_188792.1) ENSMUST00000031305.1 ENSMUST00000031305.2 ENSMUST00000031305.3 NR_188792 uc290yzo.1 uc290yzo.2 uc290yzo.1 uc290yzo.2 
ENSMUST00000031309.16 Wsb2 ENSMUST00000031309.16 WD repeat and SOCS box-containing 2 (from RefSeq NM_021539.5) ENSMUST00000031309.1 ENSMUST00000031309.10 ENSMUST00000031309.11 ENSMUST00000031309.12 ENSMUST00000031309.13 ENSMUST00000031309.14 ENSMUST00000031309.15 ENSMUST00000031309.2 ENSMUST00000031309.3 ENSMUST00000031309.4 ENSMUST00000031309.5 ENSMUST00000031309.6 ENSMUST00000031309.7 ENSMUST00000031309.8 ENSMUST00000031309.9 NM_021539 O54929 Q6GTI7 Q9R1M8 Swip2 WSB2_MOUSE uc008zfq.1 uc008zfq.2 uc008zfq.3 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. molecular_function cellular_component biological_process protein ubiquitination intracellular signal transduction uc008zfq.1 uc008zfq.2 uc008zfq.3 
ENSMUST00000031311.10 Dck ENSMUST00000031311.10 deoxycytidine kinase (from RefSeq NM_007832.4) Dck ENSMUST00000031311.1 ENSMUST00000031311.2 ENSMUST00000031311.3 ENSMUST00000031311.4 ENSMUST00000031311.5 ENSMUST00000031311.6 ENSMUST00000031311.7 ENSMUST00000031311.8 ENSMUST00000031311.9 NM_007832 Q545E8 Q545E8_MOUSE uc008yah.1 uc008yah.2 uc008yah.3 Reaction=2'-deoxyadenosine + ATP = ADP + dAMP + H(+); Xref=Rhea:RHEA:23452, ChEBI:CHEBI:15378, ChEBI:CHEBI:17256, ChEBI:CHEBI:30616, ChEBI:CHEBI:58245, ChEBI:CHEBI:456216; EC=2.7.1.76; Evidence=; Reaction=2'-deoxycytidine + a ribonucleoside 5'-triphosphate = a ribonucleoside 5'-diphosphate + dCMP + H(+); Xref=Rhea:RHEA:20061, ChEBI:CHEBI:15378, ChEBI:CHEBI:15698, ChEBI:CHEBI:57566, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=2.7.1.74; Evidence=; Reaction=2'-deoxyguanosine + ATP = ADP + dGMP + H(+); Xref=Rhea:RHEA:19201, ChEBI:CHEBI:15378, ChEBI:CHEBI:17172, ChEBI:CHEBI:30616, ChEBI:CHEBI:57673, ChEBI:CHEBI:456216; EC=2.7.1.113; Evidence=; Homodimer. Nucleus Belongs to the DCK/DGK family. nucleotide binding deoxycytidine kinase activity ATP binding nucleus nucleobase-containing compound metabolic process pyrimidine nucleotide metabolic process drug binding deoxyribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process kinase activity phosphorylation nucleoside kinase activity protein homodimerization activity uc008yah.1 uc008yah.2 uc008yah.3 
ENSMUST00000031314.10 Alb ENSMUST00000031314.10 albumin (from RefSeq NM_009654.4) Alb Alb1 ENSMUST00000031314.1 ENSMUST00000031314.2 ENSMUST00000031314.3 ENSMUST00000031314.4 ENSMUST00000031314.5 ENSMUST00000031314.6 ENSMUST00000031314.7 ENSMUST00000031314.8 ENSMUST00000031314.9 NM_009654 Q546G4 Q546G4_MOUSE alb uc008yaz.1 uc008yaz.2 uc008yaz.3 uc008yaz.4 uc008yaz.5 This gene encodes albumin, an abundant plasma protein essential for maintaining oncotic pressure that functions as a carrier protein for various molecules such as steriods and fatty acids in blood. This gene is primarily expressed in liver where the encoded protein undergoes proteolytic processing before secretion into the plasma. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ011413.1, AK131891.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Secreted DNA binding fatty acid binding extracellular space endoplasmic reticulum Golgi apparatus drug binding cellular response to starvation toxic substance binding oxygen binding pyridoxal phosphate binding negative regulation of protein oligomerization macromolecular complex identical protein binding negative regulation of apoptotic process metal ion binding chaperone binding maintenance of mitochondrion location extracellular exosome enterobactin binding uc008yaz.1 uc008yaz.2 uc008yaz.3 uc008yaz.4 uc008yaz.5 
ENSMUST00000031317.10 Rassf6 ENSMUST00000031317.10 Ras association (RalGDS/AF-6) domain family member 6, transcript variant 1 (from RefSeq NM_028478.4) ENSMUST00000031317.1 ENSMUST00000031317.2 ENSMUST00000031317.3 ENSMUST00000031317.4 ENSMUST00000031317.5 ENSMUST00000031317.6 ENSMUST00000031317.7 ENSMUST00000031317.8 ENSMUST00000031317.9 G3X8Z9 NM_028478 Q80UQ2 Q9DAW2 RASF6_MOUSE uc008ybd.1 uc008ybd.2 uc008ybd.3 uc008ybd.4 Involved in the induction of apoptosis. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF- kappa-B. Interacts with MOAP1. Interaction with activated KRAS is still a matter of debate: interaction has been shown in the mouse (PubMed:17404571), but not in human (PubMed:17367779). Lack of interaction with MRAS, NRAS nor RRAS2 has also been reported (PubMed:17367779). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80UQ2-1; Sequence=Displayed; Name=2; IsoId=Q80UQ2-2; Sequence=VSP_019373; Sequence=AAH39934.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH39934.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Contains an insertion not found in the reference genome.; Evidence=; protein binding cellular_component apoptotic process signal transduction regulation of apoptotic process positive regulation of apoptotic process uc008ybd.1 uc008ybd.2 uc008ybd.3 uc008ybd.4 
ENSMUST00000031318.6 Cxcl5 ENSMUST00000031318.6 C-X-C motif chemokine ligand 5 (from RefSeq NM_009141.3) CXCL5_MOUSE ENSMUST00000031318.1 ENSMUST00000031318.2 ENSMUST00000031318.3 ENSMUST00000031318.4 ENSMUST00000031318.5 NM_009141 P50228 Q8K3I3 Scyb5 uc008ybg.1 uc008ybg.2 uc008ybg.3 uc008ybg.4 This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U27267.1, BC024392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## May participate in the recruitment of inflammatory cells by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-2(9-78) attract neutrophils and are involved in neutrophil activation. Monomer. Homodimer. Secreted. By lipopolysaccharide (LPS). GCP-2(1-78) and GCP-2(9-78) are produced by proteolytic cleavage after secretion from fibroblasts and epithelial cells. GCP-2(9-78) is the most prominent form. A number of additional N-terminal (processed between pos. 41 and 48) and C-terminal (processed between pos. 118 and 132) processed forms have been identified, probably also representing intermediate states. Belongs to the intercrine alpha (chemokine CxC) family. leukocyte homeostasis cytokine production cytokine activity extracellular region extracellular space chemotaxis defense response inflammatory response immune response chemokine activity positive regulation of neuron projection development neutrophil chemotaxis leukocyte chemotaxis animal organ regeneration response to lipopolysaccharide regulation of chemokine production neutrophil activation positive regulation of JAK-STAT cascade chemokine-mediated signaling pathway regulation of neutrophil mediated killing of gram-negative bacterium cellular response to lipopolysaccharide uc008ybg.1 uc008ybg.2 uc008ybg.3 uc008ybg.4 
ENSMUST00000031319.8 Ppbp ENSMUST00000031319.8 pro-platelet basic protein (from RefSeq NM_023785.3) Cxcl7 ENSMUST00000031319.1 ENSMUST00000031319.2 ENSMUST00000031319.3 ENSMUST00000031319.4 ENSMUST00000031319.5 ENSMUST00000031319.6 ENSMUST00000031319.7 NM_023785 Ppbp Q9EQI5 Q9EQI5_MOUSE uc008ybh.1 uc008ybh.2 uc008ybh.3 uc008ybh.4 Secreted Belongs to the intercrine alpha (chemokine CxC) family. leukocyte migration involved in inflammatory response extracellular region extracellular space chemotaxis defense response inflammatory response immune response chemokine activity neutrophil chemotaxis leukocyte chemotaxis chemokine-mediated signaling pathway cellular response to lipopolysaccharide uc008ybh.1 uc008ybh.2 uc008ybh.3 uc008ybh.4 
ENSMUST00000031320.8 Pf4 ENSMUST00000031320.8 platelet factor 4 (from RefSeq NM_019932.5) Cxcl4 ENSMUST00000031320.1 ENSMUST00000031320.2 ENSMUST00000031320.3 ENSMUST00000031320.4 ENSMUST00000031320.5 ENSMUST00000031320.6 ENSMUST00000031320.7 NM_019932 PLF4_MOUSE Q9Z126 Scyb4 uc008ybi.1 uc008ybi.2 uc008ybi.3 Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity). Homotetramer. Interacts with TNFAIP6 (via Link domain). Secreted. Belongs to the intercrine alpha (chemokine CxC) family. cytokine activity extracellular region extracellular space cytoplasm chemotaxis defense response inflammatory response immune response adenylate cyclase-activating G-protein coupled receptor signaling pathway chemokine activity heparin binding positive regulation of gene expression positive regulation of macrophage derived foam cell differentiation negative regulation of angiogenesis cytokine-mediated signaling pathway symbiont-containing vacuole membrane platelet activation host cell cytoplasm neutrophil chemotaxis leukocyte chemotaxis platelet alpha granule killing of cells of other organism vesicle positive regulation of tumor necrosis factor production macromolecular complex regulation of cell proliferation defense response to protozoan negative regulation of MHC class II biosynthetic process positive regulation of macrophage differentiation negative regulation of megakaryocyte differentiation negative regulation of cytolysis positive regulation of transcription from RNA polymerase II promoter CXCR3 chemokine receptor binding killing by host of symbiont cells macromolecular complex assembly chemokine-mediated signaling pathway cellular response to lipopolysaccharide negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc008ybi.1 uc008ybi.2 uc008ybi.3 
ENSMUST00000031322.7 Cxcl15 ENSMUST00000031322.7 C-X-C motif chemokine ligand 15 (from RefSeq NM_011339.2) CXL15_MOUSE ENSMUST00000031322.1 ENSMUST00000031322.2 ENSMUST00000031322.3 ENSMUST00000031322.4 ENSMUST00000031322.5 ENSMUST00000031322.6 NM_011339 Q3UQ15 Q9WVL7 Scyb15 uc008ybk.1 uc008ybk.2 Chemotactic for neutrophils. Involved in lung-specific neutrophil trafficking during normal and inflammatory conditions. Secreted Expression restricted to the lung, produced by bronchoepithelial cells and is released into the airways. Expressed at low levels in fetal lung. By inflammation; in lung. Mice develop normally and are fertile. They display normal leukocyte subpopulations in peripheral blood and bone marrow, but the amount of neutrophils is reduced in the airspace. Susceptibility to pneumonia induced by K.pneumoniae is increased with decreased survival and increased bacterial burden in lung. Belongs to the intercrine alpha (chemokine CxC) family. cytokine activity extracellular region extracellular space chemotaxis defense response inflammatory response immune response chemokine activity hemopoiesis neutrophil chemotaxis leukocyte chemotaxis chemokine-mediated signaling pathway cellular response to lipopolysaccharide uc008ybk.1 uc008ybk.2 
ENSMUST00000031324.6 Ereg ENSMUST00000031324.6 epiregulin (from RefSeq NM_007950.2) ENSMUST00000031324.1 ENSMUST00000031324.2 ENSMUST00000031324.3 ENSMUST00000031324.4 ENSMUST00000031324.5 EREG_MOUSE NM_007950 Q61521 Q7M0A8 uc008ybs.1 uc008ybs.2 uc008ybs.3 Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (By similarity). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). Interacts with EGFR and ERBB4. [Epiregulin]: Secreted, extracellular space [Proepiregulin]: Cell membrane ; Single-pass type I membrane protein Expressed in 7-day-old embryos with levels then falling to very low or undetectable amounts. Not detected in adult. angiogenesis ovarian cumulus expansion oocyte maturation positive regulation of cytokine production epidermal growth factor receptor binding extracellular region extracellular space plasma membrane female meiotic division epidermal growth factor receptor signaling pathway cell-cell signaling multicellular organism development growth factor activity positive regulation of cell proliferation negative regulation of cell proliferation mRNA transcription anatomical structure morphogenesis animal organ morphogenesis membrane integral component of membrane cytokine-mediated signaling pathway cell differentiation ovulation positive regulation of cytokine biosynthetic process positive regulation of phosphorylation luteinizing hormone signaling pathway response to peptide hormone keratinocyte proliferation positive regulation of innate immune response positive regulation of interleukin-6 biosynthetic process positive regulation of DNA replication positive regulation of epidermal growth factor-activated receptor activity positive regulation of mitotic nuclear division positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of fibroblast proliferation primary follicle stage positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell differentiation positive regulation of cell division uc008ybs.1 uc008ybs.2 uc008ybs.3 
ENSMUST00000031325.6 Areg ENSMUST00000031325.6 amphiregulin (from RefSeq NM_009704.4) Areg ENSMUST00000031325.1 ENSMUST00000031325.2 ENSMUST00000031325.3 ENSMUST00000031325.4 ENSMUST00000031325.5 NM_009704 Q4FJT2 Q4FJT2_MOUSE uc008ybt.1 uc008ybt.2 uc008ybt.3 This gene encodes a member of the epidermal growth factor (EGF) family and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and has been shown to play a role in immunity, inflammation, tissue repair, and lung and mammary gland development. Homozygous knockout mice for this gene exhibit impaired immune system regulation in the skin and gene expression changes characteristic of chronic liver damage. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK018590.1, D12648.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Lacks conserved residue(s) required for the propagation of feature annotation. epidermal growth factor receptor binding extracellular space epidermal growth factor receptor signaling pathway G-protein coupled receptor signaling pathway growth factor activity positive regulation of cell proliferation cell surface glial cell proliferation response to organic cyclic compound membrane integral component of membrane neuron projection development positive regulation of phosphorylation response to hydrogen peroxide response to peptide hormone negative regulation of osteoblast differentiation response to glucocorticoid response to cAMP uc008ybt.1 uc008ybt.2 uc008ybt.3 
ENSMUST00000031326.10 Cxcl3 ENSMUST00000031326.10 C-X-C motif chemokine ligand 3 (from RefSeq NM_203320.3) CXCL3_MOUSE Cxcl3 Dcip1 ENSMUST00000031326.1 ENSMUST00000031326.2 ENSMUST00000031326.3 ENSMUST00000031326.4 ENSMUST00000031326.5 ENSMUST00000031326.6 ENSMUST00000031326.7 ENSMUST00000031326.8 ENSMUST00000031326.9 Gm1960 NM_203320 Q3UNK9 Q6W5C0 uc008ybj.1 uc008ybj.2 uc008ybj.3 uc008ybj.4 This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. [provided by RefSeq, May 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AY311403.1, AK144158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. Secreted By lipopolysaccharide. Belongs to the intercrine alpha (chemokine CxC) family. Sequence=BAE25738.1; Type=Frameshift; Evidence=; cytokine activity protein binding extracellular region extracellular space cell chemotaxis defense response inflammatory response immune response positive regulation of cytosolic calcium ion concentration chemokine activity neutrophil chemotaxis leukocyte chemotaxis response to lipopolysaccharide chemokine-mediated signaling pathway cellular response to lipopolysaccharide uc008ybj.1 uc008ybj.2 uc008ybj.3 uc008ybj.4 
ENSMUST00000031327.9 Cxcl1 ENSMUST00000031327.9 C-X-C motif chemokine ligand 1 (from RefSeq NM_008176.3) ENSMUST00000031327.1 ENSMUST00000031327.2 ENSMUST00000031327.3 ENSMUST00000031327.4 ENSMUST00000031327.5 ENSMUST00000031327.6 ENSMUST00000031327.7 ENSMUST00000031327.8 GROA_MOUSE Gro Gro1 Mgsa NM_008176 P12850 Scyb1 uc008ybl.1 uc008ybl.2 uc008ybl.3 uc008ybl.4 uc008ybl.5 This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC037997.1, J04596.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity. Secreted. By platelet-derived growth factor. In lung, by lipopolysaccharide or inflammation (By similarity). The N-terminal processed form KC(5-72) is produced by proteolytic cleavage after secretion from bone marrow stromal cells. Belongs to the intercrine alpha (chemokine CxC) family. response to molecule of bacterial origin acute inflammatory response cytokine activity extracellular region extracellular space cell chemotaxis defense response inflammatory response immune response positive regulation of cytosolic calcium ion concentration chemokine activity growth factor activity positive regulation of sodium ion transport neutrophil chemotaxis leukocyte chemotaxis killing of cells of other organism positive regulation of superoxide anion generation positive regulation of potassium ion transport chemokine-mediated signaling pathway positive regulation of neutrophil mediated killing of fungus cellular response to lipopolysaccharide positive regulation of hematopoietic stem cell proliferation uc008ybl.1 uc008ybl.2 uc008ybl.3 uc008ybl.4 uc008ybl.5 
ENSMUST00000031330.5 2010109A12Rik ENSMUST00000031330.5 RIKEN cDNA 2010109A12 gene (from RefSeq NM_029363.1) 2010109A12Rik ENSMUST00000031330.1 ENSMUST00000031330.2 ENSMUST00000031330.3 ENSMUST00000031330.4 NM_029363 Q9D875 Q9D875_MOUSE uc029vjl.1 uc029vjl.2 uc029vjl.3 molecular_function cellular_component biological_process uc029vjl.1 uc029vjl.2 uc029vjl.3 
ENSMUST00000031331.13 Ccng2 ENSMUST00000031331.13 cyclin G2 (from RefSeq NM_007635.4) Ccng2 ENSMUST00000031331.1 ENSMUST00000031331.10 ENSMUST00000031331.11 ENSMUST00000031331.12 ENSMUST00000031331.2 ENSMUST00000031331.3 ENSMUST00000031331.4 ENSMUST00000031331.5 ENSMUST00000031331.6 ENSMUST00000031331.7 ENSMUST00000031331.8 ENSMUST00000031331.9 NM_007635 Q5HZK4 Q5HZK4_MOUSE uc008yee.1 uc008yee.2 uc008yee.3 uc008yee.4 Belongs to the cyclin family. regulation of cell cycle uc008yee.1 uc008yee.2 uc008yee.3 uc008yee.4 
ENSMUST00000031333.4 Gtf2h3 ENSMUST00000031333.4 general transcription factor IIH, polypeptide 3 (from RefSeq NM_181410.3) ENSMUST00000031333.1 ENSMUST00000031333.2 ENSMUST00000031333.3 NM_181410 Q8VD76 TF2H3_MOUSE uc012edo.1 uc012edo.2 uc012edo.3 Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3- subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription (By similarity). Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7 (PubMed:9230306). Nucleus Belongs to the TFB4 family. core TFIIH complex portion of holo TFIIH complex core TFIIH complex protein kinase activity nucleus nucleoplasm transcription factor TFIID complex holo TFIIH complex DNA repair nucleotide-excision repair regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cellular response to DNA damage stimulus DNA-dependent ATPase activity RNA polymerase II carboxy-terminal domain kinase activity obsolete general RNA polymerase II transcription factor activity metal ion binding protein N-terminus binding phosphorylation of RNA polymerase II C-terminal domain transcriptional preinitiation complex uc012edo.1 uc012edo.2 uc012edo.3 
ENSMUST00000031334.15 Eif2b1 ENSMUST00000031334.15 eukaryotic translation initiation factor 2B, subunit alpha (from RefSeq NM_145371.4) EI2BA_MOUSE ENSMUST00000031334.1 ENSMUST00000031334.10 ENSMUST00000031334.11 ENSMUST00000031334.12 ENSMUST00000031334.13 ENSMUST00000031334.14 ENSMUST00000031334.2 ENSMUST00000031334.3 ENSMUST00000031334.4 ENSMUST00000031334.5 ENSMUST00000031334.6 ENSMUST00000031334.7 ENSMUST00000031334.8 ENSMUST00000031334.9 NM_145371 Q99LC8 uc008zqd.1 uc008zqd.2 uc008zqd.3 uc008zqd.4 This gene encodes the alpha subunit of the eukaryotic translation initiation factor complex 2B (eIF2B). The eIF2B complex is a heterodecamer comprised of two molecules each of alpha, beta, gamma, delta and epsilon subunits. The eIF2B complex is a critical regulator of protein synthesis acting as the guanine nucleotide exchange factor for eIF2 to enable the formation of ternary complex that is required for the initiation of mRNA translation. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133695.1, BC003426.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. Activated by the chemical integrated stress response (ISR) inhibitor ISRIB which stimulates guanine nucleotide exchange factor activity for both phosphorylated and unphosphorylated eIF2. Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides. Cytoplasm, cytosol Belongs to the eIF-2B alpha/beta/delta subunits family. translation initiation factor activity guanyl-nucleotide exchange factor activity protein binding GTP binding cytoplasm eukaryotic translation initiation factor 2 complex eukaryotic translation initiation factor 2B complex plasma membrane translation translational initiation regulation of translational initiation response to heat response to glucose oligodendrocyte development membrane GDP binding identical protein binding response to peptide hormone cellular metabolic process T cell receptor signaling pathway negative regulation of guanyl-nucleotide exchange factor activity response to amino acid starvation uc008zqd.1 uc008zqd.2 uc008zqd.3 uc008zqd.4 
ENSMUST00000031344.13 Mphosph9 ENSMUST00000031344.13 M-phase phosphoprotein 9, transcript variant 6 (from RefSeq NR_176471.1) A0A8Q0P9S6 A6H5Y1 E9QPF8 ENSMUST00000031344.1 ENSMUST00000031344.10 ENSMUST00000031344.11 ENSMUST00000031344.12 ENSMUST00000031344.2 ENSMUST00000031344.3 ENSMUST00000031344.4 ENSMUST00000031344.5 ENSMUST00000031344.6 ENSMUST00000031344.7 ENSMUST00000031344.8 ENSMUST00000031344.9 MPP9_MOUSE NR_176471 Q8BUK7 Q8BV15 V9GX48 uc008zph.1 uc008zph.2 uc008zph.3 Negatively regulates cilia formation by recruiting the CP110- CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (By similarity). Interacts with CCP110, CEP97 and KIF24. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Golgi apparatus membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localizes to the distal and proximal end of daughter centriole and proximal of the mother centriole but not in the distal end of the mother centriole (By similarity). Recruited by KIF24 to the distal end of mother centriole where it forms a ring-like structure (By similarity). TTBK2-mediated phosphorylation at Ser-710 and Ser-717, promotes its ubiquitination at Lys-713 leading to proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex from the mother centrioles, promoting the initiation of ciliogenesis (By similarity). Phosphorylated in M (mitotic) phase (By similarity). Ubiquitinated at Lys-713, leading to proteasomal degradation. Knockout mice show decreased body weight when compared with wild-type mice around 1 month after birth (PubMed:30375385). An increased percentage of ciliated cells in the proximal and distal tubules is observed in the kidneys of knockout mice at 1 and 4 months after birth (PubMed:30375385). Sequence=AAI38424.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI45682.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC39220.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi membrane molecular_function cytoplasm Golgi apparatus centriole cytoskeleton biological_process membrane uc008zph.1 uc008zph.2 uc008zph.3 
ENSMUST00000031345.15 Rchy1 ENSMUST00000031345.15 ring finger and CHY zinc finger domain containing 1, transcript variant 1 (from RefSeq NM_026557.5) Arnip Chimp ENSMUST00000031345.1 ENSMUST00000031345.10 ENSMUST00000031345.11 ENSMUST00000031345.12 ENSMUST00000031345.13 ENSMUST00000031345.14 ENSMUST00000031345.2 ENSMUST00000031345.3 ENSMUST00000031345.4 ENSMUST00000031345.5 ENSMUST00000031345.6 ENSMUST00000031345.7 ENSMUST00000031345.8 ENSMUST00000031345.9 NM_026557 Q920H0 Q9CR50 ZN363_MOUSE Zfp363 Znf363 uc008yby.1 uc008yby.2 uc008yby.3 uc008yby.4 This gene encodes a protein containing CHY-, CTCHY-, and RING-type zinc-fingers. The encoded protein functions as an E3 ubiquitin ligase, and mediates the degradation of target proteins such as p53. The activity of this protein is important in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]. E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (By similarity). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (By similarity). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:12654245). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Monomer and homodimer. Interacts with AR, MDM2, KAT5, PLAG1, PLAGL2, COPE, UBE2D2 and GORAB/NTKLBP1. Nucleus Nucleus speckle Cytoplasm Detected in testis, liver, kidney and heart. Up-regulated upon p53/TP53 activation. Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability. ubiquitin ligase complex p53 binding ubiquitin-protein transferase activity receptor binding nucleus nucleoplasm cytoplasm cytosol ubiquitin-dependent protein catabolic process zinc ion binding protein ubiquitination nuclear speck transferase activity positive regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein homodimerization activity metal ion binding protein autoubiquitination uc008yby.1 uc008yby.2 uc008yby.3 uc008yby.4 
ENSMUST00000031347.8 Rilpl2 ENSMUST00000031347.8 Rab interacting lysosomal protein-like 2 (from RefSeq NM_030259.1) ENSMUST00000031347.1 ENSMUST00000031347.2 ENSMUST00000031347.3 ENSMUST00000031347.4 ENSMUST00000031347.5 ENSMUST00000031347.6 ENSMUST00000031347.7 NM_030259 Q3TB73 Q99LE1 RIPL2_MOUSE uc008zpx.1 uc008zpx.2 uc008zpx.3 Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (PubMed:23264467). May function via activation of RAC1 and PAK1 (By similarity). Homodimer (PubMed:23798443). Interacts with RAC1 (By similarity). Interacts (via N-terminus) with MYO5A, the interaction is required for its role in dendrite formation (PubMed:23798443). Interacts with RAB8A; interaction is dependent on the phosphorylation of RAB8A on 'Thr-72' (PubMed:29125462). Interacts with RAB10 and RAB12; interaction is dependent on the phosphorylation of 'Thr-73' on RAB10 and 'Ser-105' on RAB12 (By similarity). Cytoplasm, cytosol Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cell projection, cilium Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99LE1-1; Sequence=Displayed; Name=2; IsoId=Q99LE1-2; Sequence=VSP_030853; Belongs to the RILPL family. epithelial cell morphogenesis cytoplasm centrosome microtubule organizing center cytosol cytoskeleton cilium protein transport membrane small GTPase binding identical protein binding cell projection protein dimerization activity dynein light intermediate chain binding protein transport from ciliary membrane to plasma membrane uc008zpx.1 uc008zpx.2 uc008zpx.3 
ENSMUST00000031349.9 Snrnp35 ENSMUST00000031349.9 small nuclear ribonucleoprotein 35 (U11/U12) (from RefSeq NM_029532.2) ENSMUST00000031349.1 ENSMUST00000031349.2 ENSMUST00000031349.3 ENSMUST00000031349.4 ENSMUST00000031349.5 ENSMUST00000031349.6 ENSMUST00000031349.7 ENSMUST00000031349.8 NM_029532 Q8CAC7 Q9D384 U1SBP_MOUSE U1snrnpbp uc008zpy.1 uc008zpy.2 uc008zpy.3 Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Nucleus mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding nucleus spliceosomal complex U12-type spliceosomal complex nucleolus mRNA processing RNA splicing uc008zpy.1 uc008zpy.2 uc008zpy.3 
ENSMUST00000031351.11 Arl6ip4 ENSMUST00000031351.11 ADP-ribosylation factor-like 6 interacting protein 4 (from RefSeq NM_144509.2) AR6P4_MOUSE ENSMUST00000031351.1 ENSMUST00000031351.10 ENSMUST00000031351.2 ENSMUST00000031351.3 ENSMUST00000031351.4 ENSMUST00000031351.5 ENSMUST00000031351.6 ENSMUST00000031351.7 ENSMUST00000031351.8 ENSMUST00000031351.9 NM_144509 Q9JM93 Q9WUG8 uc008zoz.1 uc008zoz.2 uc008zoz.3 Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. Interacts with ZCCHC17 (By similarity). Interacts with SRSF2 (By similarity). Interacts with ARL6. Nucleus, nucleolus Nucleus speckle Widely expressed. Expressed at high level in testis and thymus. Belongs to the ARL6IP4 family. Sequence=AAD33049.1; Type=Miscellaneous discrepancy; Note=Low quality sequence that contains many discrepancies.; Evidence=; protein binding nucleus nucleolus mRNA processing RNA splicing nuclear speck uc008zoz.1 uc008zoz.2 uc008zoz.3 
ENSMUST00000031354.11 Abcb9 ENSMUST00000031354.11 ATP-binding cassette, sub-family B member 9 (from RefSeq NM_019875.2) ABCB9_MOUSE Abcb9 ENSMUST00000031354.1 ENSMUST00000031354.10 ENSMUST00000031354.2 ENSMUST00000031354.3 ENSMUST00000031354.4 ENSMUST00000031354.5 ENSMUST00000031354.6 ENSMUST00000031354.7 ENSMUST00000031354.8 ENSMUST00000031354.9 Kiaa1520 NM_019875 Q8CHA1 Q9D212 Q9JIN1 Q9JJ59 uc008zou.1 uc008zou.2 uc008zou.3 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may be associated with lysosome activity. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AF216495.1, AB093298.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Reaction=a [oligopeptide](in) + ATP + H2O = a [oligopeptide](out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:14429, Rhea:RHEA-COMP:10531, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:83228, ChEBI:CHEBI:456216; EC=7.4.2.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14430; Evidence=; Homodimer. Interacts (via TMD0 region) with LAMP1; this interaction strongly stabilizes ABCB9 and protects ABCB9 against lysosomal degradation. Interacts (via TMD0 region) with LAMP2 (isoform LAMP-2B). Interacts (via TMD0) with YIF1B; this interaction allows (but is not essential) the ER-to-Golgi trafficking and strongly depends on a salt bridge within TMD0. Lysosome membrane ; Multi-pass membrane protein te=May be located in membrane rafts. Takes an intracellular route from the endoplasmic reticulum (ER), via Golgi and early endosomes to late endosomal and lysosomal compartments. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JJ59-1; Sequence=Displayed; Name=2; IsoId=Q9JJ59-2; Sequence=VSP_000032, VSP_000033; Highly expressed in testis, particularly in the Sertoli cells of the seminiferous tubules, and at moderate levels in brain and spinal cord. Divided into an N-terminal domain (TMD0) comprising four transmembrane helices and the following core domain (coreABCB9). TMD0 is required for lysosomal localization and LAMP1, LAMP2 and YIF1B interaction. The core domain is required for homodimerization and peptide transport activity. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. Sequence=BAC41480.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding ATP binding lysosome lysosomal membrane endoplasmic reticulum membrane protein transport peptide-transporting ATPase activity peptide transport membrane integral component of membrane ATPase activity transmembrane transporter activity integral component of endoplasmic reticulum membrane ATPase activity, coupled to transmembrane movement of substances protein homodimerization activity intracellular membrane-bounded organelle transmembrane transport peptide transmembrane transporter activity uc008zou.1 uc008zou.2 uc008zou.3 
ENSMUST00000031355.10 Uso1 ENSMUST00000031355.10 USO1 vesicle docking factor, transcript variant 2 (from RefSeq NM_019490.2) ENSMUST00000031355.1 ENSMUST00000031355.2 ENSMUST00000031355.3 ENSMUST00000031355.4 ENSMUST00000031355.5 ENSMUST00000031355.6 ENSMUST00000031355.7 ENSMUST00000031355.8 ENSMUST00000031355.9 NM_019490 Q3T9L9 Q3TH58 Q3U1C7 Q3UMW6 Q91WE7 Q99JZ5 Q9Z1Z0 USO1_MOUSE Vdp uc008ycm.1 uc008ycm.2 General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. Homodimer. Dimerizes by parallel association of the tails, resulting in an elongated structure with two globular head domains side by side, and a long rod-like tail structure. Interacts with MIF (By similarity). Cytoplasm, cytosol Golgi apparatus membrane ; Peripheral membrane protein Note=Recycles between the cytosol and the Golgi apparatus during interphase. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Z1Z0-1; Sequence=Displayed; Name=2; IsoId=Q9Z1Z0-2; Sequence=VSP_016981; Name=3; IsoId=Q9Z1Z0-3; Sequence=VSP_016979, VSP_016980; Name=4; IsoId=Q9Z1Z0-4; Sequence=VSP_016978; Composed of a globular head, an elongated tail (coiled-coil) and a highly acidic C-terminal domain. Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells. Dephosphorylated protein associates with the Golgi membrane; phosphorylation promostes dissociation (By similarity). Belongs to the VDP/USO1/EDE1 family. Golgi membrane fibrillar center protein binding cytoplasm endoplasmic reticulum Golgi apparatus Golgi stack cytosol intracellular protein transport ER to Golgi vesicle-mediated transport Golgi organization small GTPase mediated signal transduction ER to Golgi transport vesicle membrane protein transport membrane vesicle-mediated transport secretory granule localization transcytosis Golgi vesicle docking vesicle fusion with Golgi apparatus perinuclear region of cytoplasm membrane fusion regulation of cellular response to insulin stimulus uc008ycm.1 uc008ycm.2 
ENSMUST00000031364.5 Sdad1 ENSMUST00000031364.5 SDA1 domain containing 1 (from RefSeq NM_172713.2) A0A0R4J0B7 A0A0R4J0B7_MOUSE ENSMUST00000031364.1 ENSMUST00000031364.2 ENSMUST00000031364.3 ENSMUST00000031364.4 NM_172713 Sdad1 uc008yct.1 uc008yct.2 Required for 60S pre-ribosomal subunits export to the cytoplasm. Nucleus, nucleolus Belongs to the SDA1 family. ribosomal large subunit export from nucleus nucleus nucleolus protein transport actin cytoskeleton organization ribosome biogenesis ribosomal large subunit biogenesis uc008yct.1 uc008yct.2 
ENSMUST00000031366.12 Kntc1 ENSMUST00000031366.12 kinetochore associated 1 (from RefSeq NM_001042421.1) ENSMUST00000031366.1 ENSMUST00000031366.10 ENSMUST00000031366.11 ENSMUST00000031366.2 ENSMUST00000031366.3 ENSMUST00000031366.4 ENSMUST00000031366.5 ENSMUST00000031366.6 ENSMUST00000031366.7 ENSMUST00000031366.8 ENSMUST00000031366.9 KNTC1_MOUSE Kiaa0166 NM_001042421 Q6A0B3 Q8C3Y4 uc008zoo.1 uc008zoo.2 Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity). Interacts with ZW10. This interaction is required for stable association with the kinetochore. Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH (By similarity). Cytoplasm Nucleus Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Sequence=BAD32183.1; Type=Erroneous initiation; Evidence=; chromosome, centromeric region kinetochore condensed chromosome kinetochore spindle pole molecular_function nucleus chromosome cytoplasm spindle kinetochore microtubule cytosol cytoskeleton plasma membrane cell cycle mitotic cell cycle checkpoint actin cytoskeleton cell division RZZ complex uc008zoo.1 uc008zoo.2 
ENSMUST00000031367.15 Slc15a4 ENSMUST00000031367.15 solute carrier family 15, member 4 (from RefSeq NM_133895.1) ENSMUST00000031367.1 ENSMUST00000031367.10 ENSMUST00000031367.11 ENSMUST00000031367.12 ENSMUST00000031367.13 ENSMUST00000031367.14 ENSMUST00000031367.2 ENSMUST00000031367.3 ENSMUST00000031367.4 ENSMUST00000031367.5 ENSMUST00000031367.6 ENSMUST00000031367.7 ENSMUST00000031367.8 ENSMUST00000031367.9 NM_133895 Pht1 Q7TPL5 Q91W98 S15A4_MOUSE Slc15a4 uc008zsb.1 uc008zsb.2 uc008zsb.3 Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:19570976, PubMed:21277849, PubMed:25238095, PubMed:27845049, PubMed:29305823). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29784761). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD- like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso- 2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:19570976, PubMed:23028315, PubMed:25238095, PubMed:24695226, PubMed:29784761). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:21045126, PubMed:23382217, PubMed:25238095, PubMed:30262916). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (By similarity). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (PubMed:25310967). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (PubMed:29155995). Reaction=n H(+)(out) + L-histidine(out) = n H(+)(in) + L-histidine(in); Xref=Rhea:RHEA:76379, ChEBI:CHEBI:15378, ChEBI:CHEBI:57595; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76380; Evidence=; Reaction=n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in); Xref=Rhea:RHEA:76371, ChEBI:CHEBI:15378, ChEBI:CHEBI:155830; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76372; Evidence=; Reaction=n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso- diaminoheptanedioate(out) = n H(+)(in) + L-alanyl-gamma-D-glutamyl- meso-diaminoheptanedioate(in); Xref=Rhea:RHEA:64412, ChEBI:CHEBI:15378, ChEBI:CHEBI:61401; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64413; Evidence=; Reaction=glycylglycylglycine(out) + n H(+)(out) = glycylglycylglycine(in) + n H(+)(in); Xref=Rhea:RHEA:76391, ChEBI:CHEBI:15378, ChEBI:CHEBI:195214; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76392; Evidence=; Reaction=carnosine(out) + n H(+)(out) = carnosine(in) + n H(+)(in); Xref=Rhea:RHEA:76383, ChEBI:CHEBI:15378, ChEBI:CHEBI:57485; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76384; Evidence=; Interacts with TASL; leading to TASL recruitment to endolysosome. Lysosome membrane ulti-pass membrane protein Endosome membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Preferentially expressed in immune tissues, including B-cells and dendritic cells (PubMed:21277849). Highly expressed in macrophages (PubMed:29784761). Mice are fertile and look healthy but display impaired cytokine production in dendritic cells (PubMed:21277849). Reduced uptake of L-histidine in brain (PubMed:27845049). Belongs to the major facilitator superfamily. Proton- dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. Sequence=AAK95566.1; Type=Frameshift; Evidence=; L-histidine transmembrane transporter activity oligopeptide transport protein transport symporter activity peptide:proton symporter activity histidine transport peptide transport membrane integral component of membrane transmembrane transporter activity oligopeptide transmembrane transport oligopeptide transmembrane transporter activity transmembrane transport L-histidine transmembrane transport hydrogen ion transmembrane transport peptide transmembrane transporter activity uc008zsb.1 uc008zsb.2 uc008zsb.3 
ENSMUST00000031377.9 Scarb2 ENSMUST00000031377.9 scavenger receptor class B, member 2 (from RefSeq NM_007644.4) ENSMUST00000031377.1 ENSMUST00000031377.2 ENSMUST00000031377.3 ENSMUST00000031377.4 ENSMUST00000031377.5 ENSMUST00000031377.6 ENSMUST00000031377.7 ENSMUST00000031377.8 NM_007644 O35114 Q3UNF8 SCRB2_MOUSE uc008ydm.1 uc008ydm.2 uc008ydm.3 uc008ydm.4 This gene encodes a CD36-like type III transmembrane glycoprotein that localizes to the lysosomal membrane. Mice lacking the encoded protein exhibit an increased postnatal mortality caused by an obstruction of the ureteropelvic junction, deafness, peripheral demyelinating neuropathy and tubular proteinuria. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK144235.1, AK083038.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164142 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting. Interacts with GBA1. Lysosome membrane ulti-pass membrane protein Detected in the extracts of brain, heart, lung, liver and kidney. Acylated by palmitic acid group(s). Heavily glycosylated. Belongs to the CD36 family. phosphatidylserine binding scavenger receptor activity protein binding phospholipid transporter activity lysosome lysosomal membrane plasma membrane protein targeting to lysosome receptor-mediated endocytosis positive regulation of neuron projection development cholesterol binding aminophospholipid transport membrane integral component of membrane enzyme binding endocytic vesicle membrane phosphatidylcholine binding cargo receptor activity protein homodimerization activity lysosomal lumen regulation of cellular carbohydrate catabolic process chaperone binding regulation of glucosylceramidase activity uc008ydm.1 uc008ydm.2 uc008ydm.3 uc008ydm.4 
ENSMUST00000031383.14 Ran ENSMUST00000031383.14 RAN, member RAS oncogene family, transcript variant 1 (from RefSeq NM_009391.4) ENSMUST00000031383.1 ENSMUST00000031383.10 ENSMUST00000031383.11 ENSMUST00000031383.12 ENSMUST00000031383.13 ENSMUST00000031383.2 ENSMUST00000031383.3 ENSMUST00000031383.4 ENSMUST00000031383.5 ENSMUST00000031383.6 ENSMUST00000031383.7 ENSMUST00000031383.8 ENSMUST00000031383.9 NM_009391 P17080 P28746 P28747 P62827 Q3U954 Q811M2 Q86V08 Q9CSP3 Q9CWI7 Q9CZA2 Q9UDJ5 Q9UEU9 RAN_MOUSE Rasl2-8 uc008zsr.1 uc008zsr.2 uc008zsr.3 GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide. ; Monomer. Interacts with RANGAP1, which promotes RAN-mediated GTP hydrolysis. Interacts with KPNB1. Interaction with KPNB1 inhibits RANGAP1-mediated stimulation of GTPase activity. Interacts with RCC1 which promotes the exchange of RAN-bound GDP by GTP. Interaction with KPNB1 inhibits RCC1-mediated exchange of RAN-bound GDP by GTP. Interacts (GTP-bound form) with TNPO1; the interaction is direct. Interacts (GTP-bound form) with TNPO3; the interaction is direct. Interacts with KPNB1 and with TNPO1; both inhibit RAN GTPase activity (By similarity). Interacts (via C-terminus) with RANBP1, which alleviates the inhibition of RAN GTPase activity (PubMed:7891706, PubMed:9428644). Interacts with RANGRF, which promotes the release of bound guanine nucleotide (PubMed:10811801). RANGRF and RCC1 compete for an overlapping binding site on RAN. Identified in a complex with KPNA2 and CSE1L; interaction with RANBP1 mediates dissociation of RAN from this complex. Interaction with both RANBP1 and KPNA2 promotes dissociation of the complex between RAN and KPNB1. Identified in a complex composed of RAN, RANGAP1 and RANBP1. Identified in a complex that contains TNPO1, RAN and RANBP1. Identified in a nuclear export complex with XPO1. Found in a nuclear export complex with RANBP3 and XPO1. Interacts with RANBP2/NUP358. Interaction with RANBP1 or RANBP2 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1 (By similarity). Found in a nuclear export complex with RAN, XPO5 and pre-miRNA (By similarity). Interacts (GTP- bound form) with XPO5 (By similarity). Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5 (By similarity). Interacts with RANBP9 and RANBP10 (PubMed:18347012). Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle. Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus. Interacts with MAD2L2. Interacts with VRK1 and VRK3. Interacts with VRK2 (By similarity). Interacts with NEMP1 and KPNB1 (PubMed:25946333). Interacts (GDP-bound form) with NUTF2; regulates RAN nuclear import. Interacts with CAPG; mediates CAPG nuclear import. Interacts with NUP153. Interacts with the AR N-terminal poly-Gln region; the interaction with AR is inversely correlated with the poly-Gln length (By similarity). Interacts with MYCBP2, which promotes RAN-mediated GTP hydrolysis (PubMed:26304119). Interacts with EPG5 (By similarity). P62827; Q6ZQE4: Nemp1; NbExp=7; IntAct=EBI-286564, EBI-12595939; Nucleus cleus envelope Cytoplasm, cytosol Cytoplasm Melanosome Note=Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). Expressed in a variety of tissues, including testis. Acetylation by KAT5 at Lys-134 is increased during mitosis, impairs RANGRF binding and enhances RCC1 binding. Acetylation at Lys-37 enhances the association with nuclear export components. Deacetylation of Lys-37 by SIRT7 regulates the nuclear export of NF-kappa-B subunit RELA/p65. Belongs to the small GTPase superfamily. Ran family. ribosomal large subunit export from nucleus ribosomal small subunit export from nucleus mitotic sister chromatid segregation nucleotide binding magnesium ion binding male germ cell nucleus manchette GTPase activity protein binding GTP binding nucleus nuclear envelope nuclear pore nucleoplasm nucleolus cytoplasm centriole cytosol protein import into nucleus protein export from nucleus nucleocytoplasmic transport cell cycle protein transport GDP binding protein domain specific binding actin cytoskeleton organization midbody positive regulation of protein binding macromolecular complex cellular protein localization cellular protein complex localization sperm flagellum positive regulation of protein import into nucleus melanosome RNA nuclear export complex regulation of protein binding macromolecular complex binding dynein intermediate chain binding GTP metabolic process metal ion binding protein heterodimerization activity cell division recycling endosome snRNA import into nucleus importin-alpha family protein binding protein localization to nucleolus chromatin pre-miRNA binding uc008zsr.1 uc008zsr.2 uc008zsr.3 
ENSMUST00000031384.6 B3gnt4 ENSMUST00000031384.6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4, transcript variant 2 (from RefSeq NM_198611.2) B3GN4_MOUSE E9QPF4 ENSMUST00000031384.1 ENSMUST00000031384.2 ENSMUST00000031384.3 ENSMUST00000031384.4 ENSMUST00000031384.5 NM_198611 Q1RLK6 Q923H4 uc008znw.1 uc008znw.2 Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides. Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D- glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D- glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:14389, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:133507, ChEBI:CHEBI:134090; EC=2.4.1.149; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 31 family. Golgi membrane endoplasmic reticulum Golgi apparatus protein glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups poly-N-acetyllactosamine biosynthetic process uc008znw.1 uc008znw.2 
ENSMUST00000031388.13 Vps33a ENSMUST00000031388.13 VPS33A CORVET/HOPS core subunit, transcript variant 1 (from RefSeq NM_029929.3) Bf Buff ENSMUST00000031388.1 ENSMUST00000031388.10 ENSMUST00000031388.11 ENSMUST00000031388.12 ENSMUST00000031388.2 ENSMUST00000031388.3 ENSMUST00000031388.4 ENSMUST00000031388.5 ENSMUST00000031388.6 ENSMUST00000031388.7 ENSMUST00000031388.8 ENSMUST00000031388.9 NM_029929 Q8BGT3 Q9D2N9 VP33A_MOUSE uc008znz.1 uc008znz.2 uc008znz.3 uc008znz.4 uc008znz.5 Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG. Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, which in HOPS further associates with VPS39 and VPS41 and in CORVET with VPS8 and TGFBRAP1 (PubMed:25266290). Interacts with RAB5C (PubMed:25266290). Interacts with UVRAG, STX17, MON1A and MON1B (By similarity). Associates with adaptor protein complex 3 (AP-3) and clathrin (By similarity). Interacts with PLEKHM1 (By similarity). Cytoplasmic vesicle Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Early endosome Cytoplasmic vesicle, autophagosome Cytoplasmic vesicle, clathrin-coated vesicle Note=Defects in Vps33a are the cause of the buff mutant which exhibits hypopigmentation in the coat and eyes, due to reduced size and number of melanosomes in their cells. In addition, mice are prone to prolonged bleeding, due to a platelet-storage pool defect. Belongs to the STXBP/unc-18/SEC1 family. lysosome lysosomal membrane endosome early endosome late endosome autophagosome vesicle docking involved in exocytosis autophagy endosome to lysosome transport protein transport membrane vesicle-mediated transport clathrin-coated vesicle platelet formation HOPS complex cytoplasmic vesicle late endosome membrane melanosome localization lysosome localization CORVET complex regulation of lysosomal lumen pH pigmentation macromolecular complex binding regulation of developmental pigmentation perinuclear region of cytoplasm autophagosome maturation AP-3 adaptor complex clathrin complex uc008znz.1 uc008znz.2 uc008znz.3 uc008znz.4 uc008znz.5 
ENSMUST00000031389.12 Il31 ENSMUST00000031389.12 interleukin 31, transcript variant 1 (from RefSeq NM_029594.2) ENSMUST00000031389.1 ENSMUST00000031389.10 ENSMUST00000031389.11 ENSMUST00000031389.2 ENSMUST00000031389.3 ENSMUST00000031389.4 ENSMUST00000031389.5 ENSMUST00000031389.6 ENSMUST00000031389.7 ENSMUST00000031389.8 ENSMUST00000031389.9 IL31_MOUSE NM_029594 Q6EAL8 uc008zns.1 uc008zns.2 uc008zns.3 uc008zns.4 Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (PubMed:17379091). Induces RETNLA and serum amyloid A protein expression in macrophages (PubMed:25847241). Secreted Il31 transgenic mice develop dermatitis. A similar phenotype is caused by local delivery of Il31. immune system process cytokine activity cytokine receptor binding oncostatin-M receptor binding protein binding extracellular region extracellular space signal transduction uc008zns.1 uc008zns.2 uc008zns.3 uc008zns.4 
ENSMUST00000031390.10 Mmp17 ENSMUST00000031390.10 matrix metallopeptidase 17 (from RefSeq NM_011846.5) ENSMUST00000031390.1 ENSMUST00000031390.2 ENSMUST00000031390.3 ENSMUST00000031390.4 ENSMUST00000031390.5 ENSMUST00000031390.6 ENSMUST00000031390.7 ENSMUST00000031390.8 ENSMUST00000031390.9 MMP17_MOUSE Mt4mmp NM_011846 Q80UM9 Q9R0S3 uc008zsy.1 uc008zsy.2 uc008zsy.3 uc008zsy.4 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit dysfunctional vascular smooth muscle cells and altered extracellular matrix in the vessel wall leading to an increased susceptibility to angiotensin-II-induced thoracic aortic aneurysm. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051917.1, AK143521.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix. Expressed by monocytes and macrophages. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Belongs to the peptidase M10A family. kidney development metalloendopeptidase activity extracellular region extracellular space plasma membrane proteolysis peptidase activity metallopeptidase activity zinc ion binding membrane hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix anchored component of membrane drinking behavior metal ion binding uc008zsy.1 uc008zsy.2 uc008zsy.3 uc008zsy.4 
ENSMUST00000031391.9 Bcl7a ENSMUST00000031391.9 B cell CLL/lymphoma 7A (from RefSeq NM_029850.3) BCL7A_MOUSE ENSMUST00000031391.1 ENSMUST00000031391.2 ENSMUST00000031391.3 ENSMUST00000031391.4 ENSMUST00000031391.5 ENSMUST00000031391.6 ENSMUST00000031391.7 ENSMUST00000031391.8 NM_029850 Q8C361 Q8C8M8 Q8VD15 Q9CXE2 uc008zno.1 uc008zno.2 uc008zno.3 uc008zno.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CXE2-1; Sequence=Displayed; Name=2; IsoId=Q9CXE2-2; Sequence=VSP_019272, VSP_019273; [Isoform 2]: May be due to an intron retention. Belongs to the BCL7 family. molecular_function cellular_component biological_process uc008zno.1 uc008zno.2 uc008zno.3 uc008zno.4 
ENSMUST00000031398.14 Hpd ENSMUST00000031398.14 4-hydroxyphenylpyruvic acid dioxygenase (from RefSeq NM_008277.3) ENSMUST00000031398.1 ENSMUST00000031398.10 ENSMUST00000031398.11 ENSMUST00000031398.12 ENSMUST00000031398.13 ENSMUST00000031398.2 ENSMUST00000031398.3 ENSMUST00000031398.4 ENSMUST00000031398.5 ENSMUST00000031398.6 ENSMUST00000031398.7 ENSMUST00000031398.8 ENSMUST00000031398.9 HPPD_MOUSE NM_008277 P49429 P97322 Q3UEQ0 Q91WV9 uc008znj.1 uc008znj.2 uc008znj.3 Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism. Reaction=3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate; Xref=Rhea:RHEA:16189, ChEBI:CHEBI:15379, ChEBI:CHEBI:16169, ChEBI:CHEBI:16526, ChEBI:CHEBI:36242; EC=1.13.11.27; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16190; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Note=Binds 1 Fe cation per subunit. ; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6. Homodimer. Cytoplasm Endoplasmic reticulum membrane ; Peripheral membrane protein Golgi apparatus membrane ; Peripheral membrane protein There are two alleles (F1 and F2), F2 has Asp-104 and F1 has Asn-104. Mice are completely tolerant to the self form of the protein, but make a good antibody response to immunization with the non-self form. Note=Defects in Hpd are the cause of tyrosinemia type III. Belongs to the 4HPPD family. Golgi membrane 4-hydroxyphenylpyruvate dioxygenase activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus L-phenylalanine catabolic process tyrosine catabolic process aromatic amino acid family metabolic process membrane oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen metal ion binding dioxygenase activity oxidation-reduction process uc008znj.1 uc008znj.2 uc008znj.3 
ENSMUST00000031399.13 Psph ENSMUST00000031399.13 phosphoserine phosphatase (from RefSeq NM_133900.4) ENSMUST00000031399.1 ENSMUST00000031399.10 ENSMUST00000031399.11 ENSMUST00000031399.12 ENSMUST00000031399.2 ENSMUST00000031399.3 ENSMUST00000031399.4 ENSMUST00000031399.5 ENSMUST00000031399.6 ENSMUST00000031399.7 ENSMUST00000031399.8 ENSMUST00000031399.9 NM_133900 Psph Q3TI16 Q5XHW3 Q99LS3 SERB_MOUSE uc008zth.1 uc008zth.2 uc008zth.3 uc008zth.4 Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L- serine to L-serine. L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator. May also act on O-phospho-D-serine. Reaction=H2O + O-phospho-L-serine = L-serine + phosphate; Xref=Rhea:RHEA:21208, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384, ChEBI:CHEBI:43474, ChEBI:CHEBI:57524; EC=3.1.3.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21209; Evidence=; Reaction=H2O + O-phospho-D-serine = D-serine + phosphate; Xref=Rhea:RHEA:24873, ChEBI:CHEBI:15377, ChEBI:CHEBI:35247, ChEBI:CHEBI:43474, ChEBI:CHEBI:58680; EC=3.1.3.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24874; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3. Homodimer. Cytoplasm, cytosol Belongs to the HAD-like hydrolase superfamily. SerB family. magnesium ion binding in utero embryonic development phosphoserine phosphatase activity calcium ion binding cytoplasm L-serine metabolic process L-serine biosynthetic process cellular amino acid biosynthetic process response to mechanical stimulus dephosphorylation hydrolase activity phosphatase activity response to nutrient levels response to testosterone protein homodimerization activity neuron projection metal ion binding uc008zth.1 uc008zth.2 uc008zth.3 uc008zth.4 
ENSMUST00000031410.14 Mapkapk5 ENSMUST00000031410.14 MAP kinase-activated protein kinase 5 (from RefSeq NM_010765.2) E9QQ45 ENSMUST00000031410.1 ENSMUST00000031410.10 ENSMUST00000031410.11 ENSMUST00000031410.12 ENSMUST00000031410.13 ENSMUST00000031410.2 ENSMUST00000031410.3 ENSMUST00000031410.4 ENSMUST00000031410.5 ENSMUST00000031410.6 ENSMUST00000031410.7 ENSMUST00000031410.8 ENSMUST00000031410.9 MAPK5_MOUSE NM_010765 O54992 Q6QME4 Q6QME5 Q6QME6 Q6QME7 uc008zjq.1 uc008zjq.2 uc008zjq.3 Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Activated following phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11, ERK2/MAPK1, ERK3/MAPK6, and ERK4/MAPK4. Activated by stress-related extracellular stimuli; such as H(2)O(2), arsenite, anisomycin TNF alpha and also PMA and the calcium ionophore A23187; but to a lesser extent. In vitro, activated by SQSTM1. Inhibited by diterpenoid alkaloid noroxoaconitine. Interacts with SQSTM1 (By similarity). Interacts with ERK3/MAPK6 and ERK4/MAPK4 (via FRIEDE motif); the interaction is direct. Interacts with YWHAE; the interaction prevents phosphorylation of HSP27/HSPB1 leading to disrupt F-actin polymerization. Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export. Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=MK-5 type 1; IsoId=O54992-1; Sequence=Displayed; Name=2; Synonyms=MK-5 type 3; IsoId=O54992-2; Sequence=VSP_011600; Name=3; Synonyms=MK-5 type 4; IsoId=O54992-3; Sequence=VSP_011599; Name=4; Synonyms=MK-5 type 5; IsoId=O54992-4; Sequence=VSP_011599, VSP_011598; Name=5; Synonyms=MK-5 type 2; IsoId=O54992-5; Sequence=VSP_011598; Expressed ubiquitously. Phosphorylated on Thr-182 ERK3/MAPK6 or ERK4/MAPK4; which is the regulatory phosphorylation site and is located on the T-loop/loop 12, leading to activation. Phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11 is subject to debate. Phosphorylated at Ser-115 by PKA/PRKACA, leading to localization to the cytoplasm. Autophosphorylated. Phenotypes are different depending on reports. According to a first report, mice are viable and fertile and do not show changes in tissue morphology and behavior: they exhibit the same susceptibility to LPS-induced endotoxic shock as wild-type animals and do not show the defects in LPS-induced biosynthesis of inflammatory cytokines known to occur with Mapkapk2-deficient animals (PubMed:14560018). According to another report, both homozygous and heterozygous mutant mice are highly susceptible to skin carcinogenesis induced by DMBA (PubMed:17254968). According to a third report, mutant show embryonic lethality around 11 dpc in a C57BL/6 background (PubMed:15538386). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. The role of p38 MAPK kinases is unclear in phosphorylation and activation of Mapkapk5. According to some reports, it interacts and is phosphorylated by p38-alpha/MAPK14 and p38-beta/MAPK11 (PubMed:9480836). According to other reports, it is not activated by p38-alpha/MAPK14 and p38-beta/MAPK11 (PubMed:14560018). An explanation for these discrepancies, might be that the interaction with p38 MAPK kinases is weak and occurs only under specific conditions. nucleotide binding p53 binding protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity protein binding calmodulin binding ATP binding nucleus nucleoplasm cytoplasm cytosol regulation of translation protein phosphorylation Ras protein signal transduction calcium-dependent protein serine/threonine kinase activity kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation negative regulation of TOR signaling septin cytoskeleton positive regulation of telomere maintenance via telomerase macromolecular complex intracellular signal transduction protein autophosphorylation mitogen-activated protein kinase binding positive regulation of telomerase activity positive regulation of dendritic spine development stress-induced premature senescence positive regulation of telomere capping uc008zjq.1 uc008zjq.2 uc008zjq.3 
ENSMUST00000031411.15 Aldh2 ENSMUST00000031411.15 aldehyde dehydrogenase 2, mitochondrial, transcript variant 1 (from RefSeq NM_009656.4) Aldh2 ENSMUST00000031411.1 ENSMUST00000031411.10 ENSMUST00000031411.11 ENSMUST00000031411.12 ENSMUST00000031411.13 ENSMUST00000031411.14 ENSMUST00000031411.2 ENSMUST00000031411.3 ENSMUST00000031411.4 ENSMUST00000031411.5 ENSMUST00000031411.6 ENSMUST00000031411.7 ENSMUST00000031411.8 ENSMUST00000031411.9 NM_009656 Q544B1 Q544B1_MOUSE uc008zjt.1 uc008zjt.2 uc008zjt.3 Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence=; Homotetramer. Mitochondrion matrix Belongs to the aldehyde dehydrogenase family. aldehyde dehydrogenase (NAD) activity oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor oxidation-reduction process uc008zjt.1 uc008zjt.2 uc008zjt.3 
ENSMUST00000031414.15 Brap ENSMUST00000031414.15 BRCA1 associated protein, transcript variant 1 (from RefSeq NM_028227.3) BRAP_MOUSE Brap ENSMUST00000031414.1 ENSMUST00000031414.10 ENSMUST00000031414.11 ENSMUST00000031414.12 ENSMUST00000031414.13 ENSMUST00000031414.14 ENSMUST00000031414.2 ENSMUST00000031414.3 ENSMUST00000031414.4 ENSMUST00000031414.5 ENSMUST00000031414.6 ENSMUST00000031414.7 ENSMUST00000031414.8 ENSMUST00000031414.9 NM_028227 Q8CC00 Q8CHX1 Q99MP7 Q99MP8 Q9CXX8 uc008zkc.1 uc008zkc.2 uc008zkc.3 uc008zkc.4 Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with the nuclear localization signal of BRCA1 and with the N-terminal of KSR1. The C-terminal portion of BRCA1 interacts with DDB1. Q99MP8; O88987: Akap3; NbExp=3; IntAct=EBI-10818333, EBI-9033539; Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1 ; Synonyms=alpha ; IsoId=Q99MP8-1; Sequence=Displayed; Name=2 ; Synonyms=beta ; IsoId=Q99MP8-2; Sequence=VSP_050761; Name=3 ; IsoId=Q99MP8-3; Sequence=VSP_050762; Isoform 2 is highly expressed in testis, lower levels in brain, heart, lung, stomach, colon, uterus, liver and kidney. Isoform 1 is only expressed in the testis. Isoform 2 is predominant over isoform 1 in both fetal and adult testis. Sequence=BAB29036.1; Type=Erroneous initiation; Evidence=; ubiquitin ligase complex MAPK cascade nucleic acid binding ubiquitin-protein transferase activity protein binding cytoplasm cytosol Ras protein signal transduction nuclear localization sequence binding zinc ion binding negative regulation of signal transduction protein ubiquitination transferase activity nuclear membrane identical protein binding metal ion binding ubiquitin protein ligase activity uc008zkc.1 uc008zkc.2 uc008zkc.3 uc008zkc.4 
ENSMUST00000031419.6 Fam216a ENSMUST00000031419.6 family with sequence similarity 216, member A (from RefSeq NM_026883.4) ENSMUST00000031419.1 ENSMUST00000031419.2 ENSMUST00000031419.3 ENSMUST00000031419.4 ENSMUST00000031419.5 F216A_MOUSE NM_026883 Q3UD74 Q6PFA4 Q9DB54 uc008zld.1 uc008zld.2 uc008zld.3 Belongs to the FAM216 family. molecular_function cellular_component biological_process uc008zld.1 uc008zld.2 uc008zld.3 
ENSMUST00000031420.11 Gpn3 ENSMUST00000031420.11 GPN-loop GTPase 3 (from RefSeq NM_024216.2) Atpbd1c D5Ertd708e ENSMUST00000031420.1 ENSMUST00000031420.10 ENSMUST00000031420.2 ENSMUST00000031420.3 ENSMUST00000031420.4 ENSMUST00000031420.5 ENSMUST00000031420.6 ENSMUST00000031420.7 ENSMUST00000031420.8 ENSMUST00000031420.9 GPN3_MOUSE Gpn3 NM_024216 Q8BU32 Q9D3W4 uc008zle.1 uc008zle.2 uc008zle.3 uc008zle.4 Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Heterodimer with GPN1. Binds to RNA polymerase II (RNAPII). Interacts directly with subunits RPB4 and RPB7 and the CTD of RPB1. Belongs to the GPN-loop GTPase family. Sequence=BAC40065.1; Type=Frameshift; Evidence=; nucleotide binding GTPase activity GTP binding hydrolase activity macromolecular complex uc008zle.1 uc008zle.2 uc008zle.3 uc008zle.4 
ENSMUST00000031423.10 Atp2a2 ENSMUST00000031423.10 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2, transcript variant 1 (from RefSeq NM_001110140.3) AT2A2_MOUSE Atp2a2 ENSMUST00000031423.1 ENSMUST00000031423.2 ENSMUST00000031423.3 ENSMUST00000031423.4 ENSMUST00000031423.5 ENSMUST00000031423.6 ENSMUST00000031423.7 ENSMUST00000031423.8 ENSMUST00000031423.9 NM_001110140 O55143 Q9R2A9 Q9WUT5 uc290zkr.1 uc290zkr.2 This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER- isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes (By similarity). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis. [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle (PubMed:23395171). Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation (PubMed:23395171). Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation (PubMed:23395171). Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.10; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18106; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Has different conformational states with differential Ca2+ affinity. The E1 conformational state (active form) shows high Ca(2+) affinity, while the E2 state exhibits low Ca(2+) affinity. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations (PubMed:22971924). Inhibited by sarcolipin (SLN) and myoregulin (MRLN). The inhibition is blocked by VMP1 (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). Stabilizes SERCA2 in its E2 state (By similarity). Interacts with sarcolipin (SLN); the interaction inhibits ATP2A2 Ca(2+) affinity (By similarity). Interacts with phospholamban (PLN); the interaction inhibits ATP2A2 Ca(2+) affinity (PubMed:22971924). Interacts with myoregulin (MRLN) (By similarity). Interacts with DWORF (By similarity). Interacts with HAX1. Interacts with S100A8 and S100A9 (PubMed:18403730). Interacts with SLC35G1 and STIM1. Interacts with TMEM203 (By similarity). Interacts with TMEM64 and PDIA3 (PubMed:23395171). Interacts with TMX1 (By similarity). Interacts with TMX2. Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2. Interacts with ULK1 (By similarity). Interacts with S100A1 in a Ca(2+)- dependent manner (By similarity). Interacts with TUNAR (PubMed:35036403). Interacts with FLVCR2; this interaction occurs in the absence of heme and promotes ATP2A2 proteasomal degradation; this complex is dissociated upon heme binding (PubMed:32973183). Interacts with FNIP1 (PubMed:35412553). [Isoform 1]: Interacts with TRAM2 (via C-terminus). O55143; Q5S006: Lrrk2; NbExp=9; IntAct=EBI-770763, EBI-2693710; O55143; E2JF22: Piezo1; NbExp=3; IntAct=EBI-770763, EBI-9837938; O55143; Q5S007: LRRK2; Xeno; NbExp=13; IntAct=EBI-770763, EBI-5323863; Endoplasmic reticulum membrane ; Multi-pass membrane protein Sarcoplasmic reticulum membrane ; Multi-pass membrane protein Note=Colocalizes with FLVCR2 at the mitochondrial-ER contact junction. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Atp2a2b, SERCA2b; IsoId=O55143-1; Sequence=Displayed; Name=2; Synonyms=Atp2a2a, SERCA2a; IsoId=O55143-2; Sequence=VSP_000359; Isoform 2 is highly expressed in heart and slow twitch skeletal muscle. Isoform 2 is widely expressed. Highly up-regulated during osteoclast differentiation. Ca(2+) and ATP binding cause major rearrangements of the cytoplasmic and transmembrane domains. According to the E1-E2 model, Ca(2+) binding to the cytosolic domain of the pump in the high-affinity E1 conformation is followed by the ATP-dependent phosphorylation of the active site Asp, giving rise to E1P. A conformational change of the phosphoenzyme gives rise to the low-affinity E2P state that exposes the Ca(2+) ions to the lumenal side and promotes Ca(2+) release. Dephosphorylation of the active site Asp mediates the subsequent return to the E1 conformation. PLN and SLN both have a single transmembrane helix; both occupy a similar binding site that is situated between the ATP2A2 transmembrane helices. Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity. Serotonylated on Gln residues by TGM2 in response to hypoxia, leading to its inactivation. Sarcoplasmic reticulum collapse and volume reduction. Although dimensions of cardiomyocyte are not affected, total surface area is significantly increased, resulting in increased T- tubule density. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. nucleotide binding regulation of the force of heart contraction skeletal muscle contraction calcium-transporting ATPase activity calcium ion binding protein binding ATP binding nucleoplasm endoplasmic reticulum endoplasmic reticulum membrane ion transport calcium ion transport cellular calcium ion homeostasis regulation of muscle contraction ER-nucleus signaling pathway organelle organization protein C-terminus binding hydrogen-exporting ATPase activity, phosphorylative mechanism regulation of cardiac muscle contraction by calcium ion signaling vesicle membrane longitudinal sarcoplasmic reticulum transition between fast and slow fiber cardiac muscle hypertrophy in response to stress membrane integral component of membrane sarcoplasmic reticulum enzyme binding extrinsic component of cytoplasmic side of plasma membrane lutropin-choriogonadotropic hormone receptor binding endoplasmic reticulum calcium ion homeostasis positive regulation of endoplasmic reticulum calcium ion concentration response to lipopolysaccharide macromolecular complex sarcoplasmic reticulum membrane T-tubule organization cellular response to oxidative stress cellular response to heat response to peptide hormone S100 protein binding negative regulation of heart contraction metal ion binding perinuclear region of cytoplasm relaxation of cardiac muscle sarcoplasmic reticulum calcium ion transport calcium ion transmembrane transport regulation of cardiac muscle cell membrane potential calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential calcium ion-transporting ATPase complex ribbon synapse regulation of cardiac muscle cell action potential involved in regulation of contraction hydrogen ion transmembrane transport regulation of calcium ion-dependent exocytosis of neurotransmitter calcium ion transport from cytosol to endoplasmic reticulum calcium ion import into sarcoplasmic reticulum intercalated disc uc290zkr.1 uc290zkr.2 
ENSMUST00000031426.14 Ift81 ENSMUST00000031426.14 intraflagellar transport 81, transcript variant 2 (from RefSeq NM_009879.5) Cdv-1 Cdv1 ENSMUST00000031426.1 ENSMUST00000031426.10 ENSMUST00000031426.11 ENSMUST00000031426.12 ENSMUST00000031426.13 ENSMUST00000031426.2 ENSMUST00000031426.3 ENSMUST00000031426.4 ENSMUST00000031426.5 ENSMUST00000031426.6 ENSMUST00000031426.7 ENSMUST00000031426.8 ENSMUST00000031426.9 IFT81_MOUSE NM_009879 O35594 Q8R4W2 Q9CSA1 Q9EQM1 uc008zlm.1 uc008zlm.2 uc008zlm.3 Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling (By similarity). Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella (PubMed:32233951). [Isoform CDV-1]: May be involved in cardiac hypertrophy caused by carnitine deficiency. [Isoform CDV-1R]: May play a role in development of the testis and spermatogenesis. Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT81, and IFT88 (PubMed:19253336, PubMed:23810713). Interacts with IFT74; the interaction is direct: within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium. Interacts with tubulin; the interaction is direct (By similarity). Interacts with IFT57 and IFT70B (PubMed:23810713). Interacts with RABL2/RABL2A; binding is equal in the presence of GTP or GDP (PubMed:23055941). Interacts with IFT88 (PubMed:19253336). Interacts (via the IFT74/IFT81 heterodimer) with RABL2B (By similarity). Cell projection, cilium Cytoplasm Event=Alternative initiation; Named isoforms=2; Name=CDV-1R; IsoId=O35594-1; Sequence=Displayed; Name=CDV-1; IsoId=O35594-2; Sequence=VSP_018785; Highly expressed in the testis (at protein level) (PubMed:32233951). Co-localizes with RABL2/RABL2A in the midpiece of elongated spermatids within the testis (at protein level) (PubMed:23055941). [Isoform CDV-1R]: Expressed predominantly in the testis. [Isoform CDV-1]: Expressed specifically in heart and suppressed specifically in ventricles, but not in auricles, of carnitine-deficient juvenile visceral steatosis (JVS) mice. First detected at postnatal day (PND) 8, its level increased dramatically from PND 16 to 42 (at protein level). [Isoform CDV-1R]: Poorly expressed in the testis 15 days after birth. Levels increase sharply between days 15 and 30 reaching a maximum by day 45 and the onset of spermatogenesis. The CH (calponin-homology)-like region shows high similarity to a CH (calponin-homology) domain and mediates binding to the globular domain of tubulin. Mice show impaired spermiogenesis, abnormal sperm morphology and significantly reduced sperm number and motility (PubMed:32233951). In addition to oligozoospermia, spermatozoa show dysmorphic and non-functional flagella (PubMed:32233951). Belongs to the IFT81 family. protein binding centrosome cilium multicellular organism development spermatogenesis regulation of smoothened signaling pathway tubulin binding cell projection organization cell differentiation intraciliary transport particle B intraciliary transport involved in cilium assembly ciliary basal body intraciliary transport cell projection cilium assembly sperm midpiece sperm principal piece uc008zlm.1 uc008zlm.2 uc008zlm.3 
ENSMUST00000031429.14 P2rx4 ENSMUST00000031429.14 purinergic receptor P2X, ligand-gated ion channel 4, transcript variant 1 (from RefSeq NM_011026.3) ENSMUST00000031429.1 ENSMUST00000031429.10 ENSMUST00000031429.11 ENSMUST00000031429.12 ENSMUST00000031429.13 ENSMUST00000031429.2 ENSMUST00000031429.3 ENSMUST00000031429.4 ENSMUST00000031429.5 ENSMUST00000031429.6 ENSMUST00000031429.7 ENSMUST00000031429.8 ENSMUST00000031429.9 NM_011026 P2rx4 Q9Z257 Q9Z257_MOUSE uc008zlu.1 uc008zlu.2 uc008zlu.3 Receptor for ATP that acts as a ligand-gated ion channel. Functional P2XRs are organized as homomeric and heteromeric trimers. Membrane ulti-pass membrane protein Belongs to the P2X receptor family. nucleotide binding purinergic nucleotide receptor activity regulation of sodium ion transport response to ischemia extracellular ATP-gated cation channel activity receptor binding ion channel activity copper ion binding ATP binding plasma membrane integral component of plasma membrane ion transport signal transduction drug binding regulation of blood pressure zinc ion binding positive regulation of calcium ion transport into cytosol negative regulation of cardiac muscle hypertrophy postsynaptic density membrane integral component of membrane neuronal action potential sensory perception of pain calcium-mediated signaling cell junction axon dendrite response to ATP ion transmembrane transport response to fluid shear stress purinergic nucleotide receptor signaling pathway identical protein binding neuronal cell body terminal bouton dendritic spine positive regulation of blood vessel endothelial cell migration cell body synapse cadherin binding behavioral response to pain perinuclear region of cytoplasm response to axon injury positive regulation of calcium-mediated signaling regulation of chemotaxis sensory perception of touch protein homooligomerization positive regulation of protein kinase B signaling membrane depolarization regulation of cardiac muscle contraction relaxation of cardiac muscle excitatory postsynaptic potential calcium ion transmembrane transport cellular response to zinc ion cellular response to ATP apoptotic signaling pathway cation transmembrane transport ligand-gated calcium channel activity positive regulation of microglial cell migration positive regulation of endothelial cell chemotaxis uc008zlu.1 uc008zlu.2 uc008zlu.3 
ENSMUST00000031434.8 Rnf34 ENSMUST00000031434.8 ring finger protein 34, transcript variant 1 (from RefSeq NM_030564.2) ENSMUST00000031434.1 ENSMUST00000031434.2 ENSMUST00000031434.3 ENSMUST00000031434.4 ENSMUST00000031434.5 ENSMUST00000031434.6 ENSMUST00000031434.7 NM_030564 Q3UV45 Q99KR6 RNF34_MOUSE Rnf34 uc008zmp.1 uc008zmp.2 uc008zmp.3 E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys- 48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with CASP8 and CASP10. Interacts with p53/TP53; involved in p53/TP53 ubiquitination. Interacts (via RING-type zinc finger) with MDM2; the interaction stabilizes MDM2. Interacts (via RING-type zinc finger) with PPARGC1A. Interacts with NOD1. Cell membrane ; Peripheral membrane protein Endomembrane system ; Peripheral membrane protein Nucleus Nucleus speckle Cytoplasm, cytosol Down-regulated in response to cold exposure. The RING-type zinc finger is required for the ubiquitination of target proteins. The FYVE-type zinc finger domain is required for localization and may confer affinity for cellular compartments enriched in phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate phospholipids. Autoubiquitinated (in vitro). Proteolytically cleaved by caspases upon induction of apoptosis by TNF. p53 binding ubiquitin-protein transferase activity nucleus nucleoplasm cytoplasm cytosol plasma membrane ubiquitin-dependent protein catabolic process apoptotic process endomembrane system membrane protein ubiquitination nuclear body nuclear speck transferase activity ubiquitin protein ligase binding nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity cellular response to cold protein K48-linked ubiquitination negative regulation of signal transduction by p53 class mediator phosphatidylinositol phosphate binding negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of oxygen metabolic process negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis uc008zmp.1 uc008zmp.2 uc008zmp.3 
ENSMUST00000031437.14 Morn3 ENSMUST00000031437.14 MORN repeat containing 3, transcript variant 1 (from RefSeq NM_029112.2) ENSMUST00000031437.1 ENSMUST00000031437.10 ENSMUST00000031437.11 ENSMUST00000031437.12 ENSMUST00000031437.13 ENSMUST00000031437.2 ENSMUST00000031437.3 ENSMUST00000031437.4 ENSMUST00000031437.5 ENSMUST00000031437.6 ENSMUST00000031437.7 ENSMUST00000031437.8 ENSMUST00000031437.9 MORN3_MOUSE NM_029112 Q8C5T4 Q8VE21 Q9D5H6 uc008zna.1 uc008zna.2 uc008zna.3 Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors (By similarity). May play a role in the regulation of spermatogenesis (PubMed:25248657). Interacts with MEIG1 (PubMed:25248657). Interacts with TP53, MDM2 and SIRT1; the interactions mediate post-transcriptional modifications of TP53 by MDM2 and SIRT1 (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome Note=Localized in the acrosome in germ cells throughout spermiogenesis, it is also present in the manchette of elongating spermatids. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C5T4-1; Sequence=Displayed; Name=2; IsoId=Q8C5T4-2; Sequence=VSP_019998, VSP_019999; Expressed in testis (at protein level). In testis, expression is first detected at 30 days after birth. Abundant in the late stage of spermatogenesis. Highly expressed in the spermiogenesis stage, localized in the acrosome in germ cells throughout spermiogenesis, it is also present in the manchette of elongating spermatids. molecular_function biological_process uc008zna.1 uc008zna.2 uc008zna.3 
ENSMUST00000031445.5 Aacs ENSMUST00000031445.5 acetoacetyl-CoA synthetase (from RefSeq NM_030210.2) A1IG47 AACS_MOUSE ENSMUST00000031445.1 ENSMUST00000031445.2 ENSMUST00000031445.3 ENSMUST00000031445.4 NM_030210 Q3TCL8 Q3UD39 Q9D2R0 uc008zrs.1 uc008zrs.2 uc008zrs.3 Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (PubMed:22985732). Reaction=acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:16117, ChEBI:CHEBI:13705, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57286, ChEBI:CHEBI:57287, ChEBI:CHEBI:456215; EC=6.2.1.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16118; Evidence=; Cytoplasm, cytosol Belongs to the ATP-dependent AMP-binding enzyme family. nucleotide binding liver development catalytic activity ATP binding cytoplasm cytosol lipid metabolic process fatty acid metabolic process response to nutrient response to organonitrogen compound response to organic cyclic compound response to purine-containing compound ligase activity acetoacetate-CoA ligase activity positive regulation of insulin secretion response to oleic acid response to drug response to starvation response to ethanol butyrate-CoA ligase activity white fat cell differentiation adipose tissue development cellular response to glucose stimulus cellular response to testosterone stimulus cellular response to cholesterol uc008zrs.1 uc008zrs.2 uc008zrs.3 
ENSMUST00000031446.7 Tmem132b ENSMUST00000031446.7 transmembrane protein 132B (from RefSeq NM_001190352.2) ENSMUST00000031446.1 ENSMUST00000031446.2 ENSMUST00000031446.3 ENSMUST00000031446.4 ENSMUST00000031446.5 ENSMUST00000031446.6 F7BAB2 F7BAB2_MOUSE NM_001190352 Tmem132b uc012eds.1 uc012eds.2 uc012eds.3 Membrane ; Single- pass type I membrane protein Belongs to the TMEM132 family. molecular_function biological_process membrane integral component of membrane uc012eds.1 uc012eds.2 uc012eds.3 
ENSMUST00000031447.12 Anxa3 ENSMUST00000031447.12 annexin A3, transcript variant 1 (from RefSeq NM_013470.3) ANXA3_MOUSE Anx3 ENSMUST00000031447.1 ENSMUST00000031447.10 ENSMUST00000031447.11 ENSMUST00000031447.2 ENSMUST00000031447.3 ENSMUST00000031447.4 ENSMUST00000031447.5 ENSMUST00000031447.6 ENSMUST00000031447.7 ENSMUST00000031447.8 ENSMUST00000031447.9 NM_013470 O35639 Q3UBI0 uc008yfm.1 uc008yfm.2 uc008yfm.3 uc008yfm.4 Inhibitor of phospholipase A2, also possesses anti-coagulant properties. A pair of annexin repeats may form one binding site for calcium and phospholipid. Belongs to the annexin family. phospholipase inhibitor activity calcium ion binding calcium-dependent phospholipid binding cytoplasm cytosol plasma membrane phagocytosis positive regulation of endothelial cell migration membrane phospholipase A2 inhibitor activity hippocampus development axon dendrite phagocytic vesicle membrane animal organ regeneration specific granule defense response to bacterium neuronal cell body negative regulation of catalytic activity neutrophil degranulation positive regulation of angiogenesis calcium-dependent protein binding positive regulation of DNA metabolic process positive regulation of sequence-specific DNA binding transcription factor activity response to glucocorticoid response to growth factor uc008yfm.1 uc008yfm.2 uc008yfm.3 uc008yfm.4 
ENSMUST00000031455.5 Slc49a3 ENSMUST00000031455.5 solute carrier family 49 member 3, transcript variant 1 (from RefSeq NM_172883.3) ENSMUST00000031455.1 ENSMUST00000031455.2 ENSMUST00000031455.3 ENSMUST00000031455.4 Mfsd7a NM_172883 Q505K1 Q8CE47 S49A3_MOUSE uc008yoc.1 uc008yoc.2 uc008yoc.3 Membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. molecular_function cellular_component integral component of plasma membrane biological_process membrane integral component of membrane transmembrane transport uc008yoc.1 uc008yoc.2 uc008yoc.3 
ENSMUST00000031456.8 Pde6b ENSMUST00000031456.8 phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide (from RefSeq NM_008806.2) ENSMUST00000031456.1 ENSMUST00000031456.2 ENSMUST00000031456.3 ENSMUST00000031456.4 ENSMUST00000031456.5 ENSMUST00000031456.6 ENSMUST00000031456.7 Mpb NM_008806 P23440 PDE6B_MOUSE Pde6b Pdeb Q80UF0 rd uc008ynz.1 uc008ynz.2 uc008ynz.3 uc008ynz.4 Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP (By similarity). Necessary for the formation of a functional phosphodiesterase holoenzyme (PubMed:1847109). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (PubMed:30240620). May participate in processes of transmission and amplification of the visual signal (By similarity). Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, ChEBI:CHEBI:58115; EC=3.1.4.35; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16958; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain. Membrane ; Lipid- anchor Cell projection, cilium, photoreceptor outer segment Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P23440-1; Sequence=Displayed; Name=2; Synonyms=Beta'; IsoId=P23440-2; Sequence=VSP_004592; Note=Defects in Pde6b are the cause of the retinal degeneration (rd) allele, which is characterized by retinal degeneration (PubMed:1977087, PubMed:1656438). The retinal degeneration 1 (rd1) allele also contains a cofounding mutation in the Gpr179 gene (PubMed:25613321). Abolishes the retinal photoreceptor layer, outer nuclear layer, and outer plexiform layer in the retinal ultrastructure (PubMed:30240620). Loss of Opn1sw, Opn1mw and Rho expression in the retina (PubMed:30240620). Reduced rate of circadian photoentrainment, UVA and orange light-induced phase-shift response and Fos expression in the suprachiasmatic nuclei (SCN) in the brain (PubMed:30240620). Pde6b and Opn5 double knockout mice also show loss of retinal ultrastructures and a more severe reduction in the rate of circadian photoentrainment, light-induced phase-shift response and Fos expression in the SCN (PubMed:30240620). Belongs to the cyclic nucleotide phosphodiesterase family. photoreceptor outer segment 3',5'-cyclic-nucleotide phosphodiesterase activity plasma membrane signal transduction G-protein coupled receptor signaling pathway visual perception phosphoric diester hydrolase activity detection of light stimulus membrane hydrolase activity metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity response to stimulus regulation of cytosolic calcium ion concentration retina development in camera-type eye uc008ynz.1 uc008ynz.2 uc008ynz.3 uc008ynz.4 
ENSMUST00000031472.12 Pxmp2 ENSMUST00000031472.12 peroxisomal membrane protein 2, transcript variant 1 (from RefSeq NM_008993.3) ENSMUST00000031472.1 ENSMUST00000031472.10 ENSMUST00000031472.11 ENSMUST00000031472.2 ENSMUST00000031472.3 ENSMUST00000031472.4 ENSMUST00000031472.5 ENSMUST00000031472.6 ENSMUST00000031472.7 ENSMUST00000031472.8 ENSMUST00000031472.9 NM_008993 Pxmp2 Q5D073 Q5D073_MOUSE uc008yqj.1 uc008yqj.2 uc008yqj.3 Membrane ; Multi- pass membrane protein Belongs to the peroxisomal membrane protein PXMP2/4 family. cytoplasm peroxisomal membrane membrane integral component of membrane macromolecular complex uc008yqj.1 uc008yqj.2 uc008yqj.3 
ENSMUST00000031478.6 Ddx51 ENSMUST00000031478.6 DEAD box helicase 51 (from RefSeq NM_027156.3) DDX51_MOUSE ENSMUST00000031478.1 ENSMUST00000031478.2 ENSMUST00000031478.3 ENSMUST00000031478.4 ENSMUST00000031478.5 NM_027156 Q3U7M2 Q6P9R1 uc008yre.1 uc008yre.2 uc008yre.3 ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Nucleus, nucleolus The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus nucleolus rRNA processing hydrolase activity ribosome biogenesis uc008yre.1 uc008yre.2 uc008yre.3 
ENSMUST00000031481.13 Pus1 ENSMUST00000031481.13 Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs (PubMed:10094309, PubMed:15327771, PubMed:27197761). Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA (PubMed:10094309). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (By similarity). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (By similarity). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (By similarity). Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA (PubMed:15327771). (from UniProt Q9WU56) AK161521 ENSMUST00000031481.1 ENSMUST00000031481.10 ENSMUST00000031481.11 ENSMUST00000031481.12 ENSMUST00000031481.2 ENSMUST00000031481.3 ENSMUST00000031481.4 ENSMUST00000031481.5 ENSMUST00000031481.6 ENSMUST00000031481.7 ENSMUST00000031481.8 ENSMUST00000031481.9 MNCb-0873 PUS1_MOUSE Pus1 Q3UUC6 Q791J1 Q8C250 Q8VDQ3 Q9EQD1 Q9JJE5 Q9WU56 uc290ygl.1 uc290ygl.2 Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs (PubMed:10094309, PubMed:15327771, PubMed:27197761). Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA (PubMed:10094309). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (By similarity). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (By similarity). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (By similarity). Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA (PubMed:15327771). [Isoform 3]: Does not form pseudouridine when expressed in vitro. [Isoform 4]: Does not form pseudouridine when expressed in vitro. Reaction=a uridine in tRNA = a pseudouridine in tRNA; Xref=Rhea:RHEA:54572, Rhea:RHEA-COMP:13339, Rhea:RHEA-COMP:13934, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence= Reaction=uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA; Xref=Rhea:RHEA:22376, Rhea:RHEA-COMP:10085, Rhea:RHEA-COMP:10087, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.12; Evidence=; Reaction=a uridine in mRNA = a pseudouridine in mRNA; Xref=Rhea:RHEA:56644, Rhea:RHEA-COMP:14658, Rhea:RHEA-COMP:14659, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Monomer (By similarity). Forms a complex with RARG and the SRA1 RNA in the nucleus (PubMed:15327771). Nucleus Cytoplasm Mitochondrion Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9WU56-1; Sequence=Displayed; Name=2; IsoId=Q9WU56-2; Sequence=VSP_020114; Name=3; IsoId=Q9WU56-3; Sequence=VSP_020114, VSP_021792; Name=4; IsoId=Q9WU56-4; Sequence=VSP_020114, VSP_021791; Impaired muscle morphology and physiology leading to impaired exercise capacity (PubMed:27197761). Mice were born at the expected Mendelian frequency (PubMed:27197761). At 14 weeks, mice display reduced exercise capacity, probably caused by alterations in muscle metabolism related to mitochondrial content and oxidative capacity (PubMed:27197761). Cells show reduced pseudouridylation of cytoplasmic and mitochondrial tRNAs (PubMed:27197761). Belongs to the tRNA pseudouridine synthase TruA family. Sequence=BAA95047.1; Type=Frameshift; Evidence=; Sequence=BAC40817.1; Type=Erroneous initiation; Evidence=; tRNA binding pseudouridine synthesis steroid receptor RNA activator RNA binding RNA binding protein binding nucleus transcription factor complex nucleolus mitochondrion tRNA processing RNA modification pseudouridine synthase activity isomerase activity ligand-dependent nuclear receptor transcription coactivator activity tRNA pseudouridine synthesis positive regulation of transcription from RNA polymerase II promoter mRNA pseudouridine synthesis nuclear chromatin uc290ygl.1 uc290ygl.2 
ENSMUST00000031490.11 Ulk1 ENSMUST00000031490.11 unc-51 like kinase 1, transcript variant 2 (from RefSeq NM_009469.3) A0A0R4J0B3 A0A0R4J0B3_MOUSE ENSMUST00000031490.1 ENSMUST00000031490.10 ENSMUST00000031490.2 ENSMUST00000031490.3 ENSMUST00000031490.4 ENSMUST00000031490.5 ENSMUST00000031490.6 ENSMUST00000031490.7 ENSMUST00000031490.8 ENSMUST00000031490.9 NM_009469 Ulk1 uc008yrq.1 uc008yrq.2 uc008yrq.3 Serine/threonine-protein kinase involved in autophagy in response to starvation. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation autophagy signal transduction axonogenesis kinase activity phosphorylation transferase activity pre-autophagosomal structure membrane response to starvation protein autophosphorylation axon extension autophagy of host cells involved in interaction with symbiont uc008yrq.1 uc008yrq.2 uc008yrq.3 
ENSMUST00000031492.15 Rab35 ENSMUST00000031492.15 RAB35, member RAS oncogene family (from RefSeq NM_198163.1) ENSMUST00000031492.1 ENSMUST00000031492.10 ENSMUST00000031492.11 ENSMUST00000031492.12 ENSMUST00000031492.13 ENSMUST00000031492.14 ENSMUST00000031492.2 ENSMUST00000031492.3 ENSMUST00000031492.4 ENSMUST00000031492.5 ENSMUST00000031492.6 ENSMUST00000031492.7 ENSMUST00000031492.8 ENSMUST00000031492.9 NM_198163 Q6PHN9 RAB35_MOUSE uc008zei.1 uc008zei.2 uc008zei.3 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). That Rab is activated by the guanine exchange factors DENND1A, DENND1B and DENND1C (PubMed:20159556, PubMed:26774822). Interacts with DENND1A and DENND1B; in a nucleotide-dependent manner (PubMed:20159556, PubMed:26774822). Interacts with DENND1C; weak interaction which is nucleotide-independent (By similarity). Interacts (GTP-bound form) with ACAP2 and MICALL1; the interaction is direct and probably recruits ACAP2 and MICALL1 to membranes (PubMed:23572513). Interacts with EHD1; the interaction is indirect through MICALL1 and probably recruits EHD1 to membranes (PubMed:23572513). Interacts with GDI1, GDI2, CHM and CHML; phosphorylation at Thr-72 disrupts these interactions (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Membrane, clathrin-coated pit Cytoplasmic vesicle, clathrin-coated vesicle Endosome Melanosome Note=Present on sorting endosomes and recycling endosome tubules. Tends to be enriched in PIP2-positive cell membrane domains. During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis. Identified in stage I to stage IV melanosomes. Belongs to the small GTPase superfamily. Rab family. nucleotide binding mitotic cytokinesis GTPase activity protein binding GTP binding phosphatidylinositol-4,5-bisphosphate binding mitochondrion endosome plasma membrane clathrin-coated pit intracellular protein transport protein localization endosome membrane protein transport membrane endosomal transport GDP binding antigen processing and presentation clathrin-coated vesicle neuron projection development cell projection membrane cytoplasmic vesicle endocytic recycling Rab protein signal transduction protein localization to endosome melanosome intercellular bridge clathrin-coated endocytic vesicle plasma membrane to endosome transport anchored component of synaptic vesicle membrane cellular response to nerve growth factor stimulus uc008zei.1 uc008zei.2 uc008zei.3 
ENSMUST00000031495.11 Pla2g1b ENSMUST00000031495.11 phospholipase A2, group IB, pancreas, transcript variant 1 (from RefSeq NM_011107.2) A6H6K5 ENSMUST00000031495.1 ENSMUST00000031495.10 ENSMUST00000031495.2 ENSMUST00000031495.3 ENSMUST00000031495.4 ENSMUST00000031495.5 ENSMUST00000031495.6 ENSMUST00000031495.7 ENSMUST00000031495.8 ENSMUST00000031495.9 NM_011107 PA21B_MOUSE Pla2 Q9D7E2 Q9D884 Q9Z0Y2 uc008zdx.1 uc008zdx.2 uc008zdx.3 Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (By similarity). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (PubMed:10066760). Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (By similarity). Has anti-helminth activity in a process regulated by gut microbiota (PubMed:29024642). Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (PubMed:29024642). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence= Reaction=1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1- tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate; Xref=Rhea:RHEA:54456, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:45240, ChEBI:CHEBI:64489; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence= Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'- sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero- 3-phospho-(1'-sn-glycerol) + H(+); Xref=Rhea:RHEA:40919, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72841, ChEBI:CHEBI:75158; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40920; Evidence= Reaction=H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1- (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45424, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:78097, ChEBI:CHEBI:85217; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45425; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence=; Reaction=H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn- glycero-3-phosphoethanolamine = (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:56424, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:85334, ChEBI:CHEBI:85335; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56425; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Monomer or homodimer (By similarity). Interacts with PLA2R1; this interaction mediates intracellular signaling as well as clearance of extracellular PLA2G1B via endocytotic pathway (PubMed:10066760). Secreted Note=Secreted from pancreatic acinar cells in its inactive form. Expressed in pancreas, liver, lung and spleen (PubMed:10066760). Expressed in EPCAM-positive intestinal epithelial cell (at protein level) (PubMed:29024642). Up-regulated in EPCAM-positive intestinal epithelial cell upon helminth infection (PubMed:29024642). Up-regulated in intestinal epithelial organoids in response to stimulation with T-helper type 2 cytokines IL4 and IL13 (PubMed:29024642). Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically. Mutant mice are susceptible to H. polygyrus and N. brasiliensis infection, failing to expel larvae and retaining a sustained infection (PubMed:29024642). In response to high fat diet, mutant mice are resistant to hyperlipidemia associated with reduced hepatic very low density lipoprotein production and increased triglyceride-rich lipoprotein clearance (PubMed:21908646). Belongs to the phospholipase A2 family. innate immune response in mucosa phospholipase A2 activity receptor binding calcium ion binding extracellular region extracellular space cytosol lipid metabolic process fatty acid biosynthetic process phospholipid metabolic process positive regulation of cell proliferation phospholipid catabolic process cell surface lipid catabolic process hydrolase activity antibacterial humoral response secretory granule phosphatidylcholine metabolic process metal ion binding calcium-dependent phospholipase A2 activity positive regulation of fibroblast proliferation arachidonic acid secretion defense response to Gram-positive bacterium uc008zdx.1 uc008zdx.2 uc008zdx.3 
ENSMUST00000031501.2 1700123K08Rik ENSMUST00000031501.2 RIKEN cDNA 1700123K08 gene (from RefSeq NM_029693.2) 1700123K08Rik ENSMUST00000031501.1 NM_029693 Q9D991 Q9D991_MOUSE uc009afp.1 uc009afp.2 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc009afp.1 uc009afp.2 
ENSMUST00000031508.5 Triap1 ENSMUST00000031508.5 TP53 regulated inhibitor of apoptosis 1 (from RefSeq NM_026933.3) 15e1.1 ENSMUST00000031508.1 ENSMUST00000031508.2 ENSMUST00000031508.3 ENSMUST00000031508.4 NM_026933 Q6LCG5 Q9D8Z2 TRIA1_MOUSE uc008zds.1 uc008zds.2 uc008zds.3 Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. Reaction=a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn- glycero-3-phosphate(out); Xref=Rhea:RHEA:36435, ChEBI:CHEBI:58608; Evidence=; Monomer. Interacts with APAF1 and HSP70. Forms a complex with PRELID1 in the mitochondrion intermembrane space. Interacts with PRELID3A. Mitochondrion Mitochondrion intermembrane space Belongs to the TRIAP1/MDM35 family. p53 binding nucleoplasm cytoplasm mitochondrion mitochondrial intermembrane space lipid transport apoptotic process phospholipid transport DNA damage response, signal transduction by p53 class mediator macromolecular complex cellular response to UV negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm negative regulation of release of cytochrome c from mitochondria regulation of membrane lipid distribution negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator phosphatidic acid transporter activity positive regulation of phospholipid transport uc008zds.1 uc008zds.2 uc008zds.3 
ENSMUST00000031513.14 Srsf9 ENSMUST00000031513.14 serine and arginine-rich splicing factor 9, transcript variant 2 (from RefSeq NR_036616.1) ENSMUST00000031513.1 ENSMUST00000031513.10 ENSMUST00000031513.11 ENSMUST00000031513.12 ENSMUST00000031513.13 ENSMUST00000031513.2 ENSMUST00000031513.3 ENSMUST00000031513.4 ENSMUST00000031513.5 ENSMUST00000031513.6 ENSMUST00000031513.7 ENSMUST00000031513.8 ENSMUST00000031513.9 NR_036616 Q9CRN3 Q9D0B0 SRSF9_MOUSE Sfrs9 uc008zdq.1 uc008zdq.2 The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]. Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 (By similarity). Interacts with KHDRBS3/SLM-2 (PubMed:11118435). Interacts with HABP4. Interacts with NOL3/ARC/NOP30, NSEP1/YB-1/YB1, SAFB/SAFB1, SRSF6/SFRS6, TRA2B/SFRS10 and C1QBP. May also interact with DUSP11/PIR1 (By similarity). Nucleus Extensively phosphorylated on serine residues in the RS domain. Belongs to the splicing factor SR family. regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus nucleoplasm nucleolus mRNA processing RNA splicing response to toxic substance nuclear speck protein domain specific binding response to alkaloid mRNA cis splicing, via spliceosome negative regulation of mRNA splicing, via spliceosome uc008zdq.1 uc008zdq.2 
ENSMUST00000031519.14 Cabp1 ENSMUST00000031519.14 calcium binding protein 1, transcript variant 2 (from RefSeq NM_013879.2) CABP1_MOUSE ENSMUST00000031519.1 ENSMUST00000031519.10 ENSMUST00000031519.11 ENSMUST00000031519.12 ENSMUST00000031519.13 ENSMUST00000031519.2 ENSMUST00000031519.3 ENSMUST00000031519.4 ENSMUST00000031519.5 ENSMUST00000031519.6 ENSMUST00000031519.7 ENSMUST00000031519.8 ENSMUST00000031519.9 NM_013879 Q9JLK6 Q9JLK7 uc008zdg.1 uc008zdg.2 uc008zdg.3 Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium- dependent facilitation of voltage-dependent P/Q-type calcium channels (By similarity). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (PubMed:17050707, PubMed:17947313). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity). Required for the normal transfer of light signals through the retina (PubMed:27822497). Homodimer; when bound to calcium or magnesium. Interacts (via C-terminus) with ITPR1, ITPR2 and ITPR3. This binding is calcium dependent and the interaction correlates with calcium concentration. An additional calcium-independent interaction with the N-terminus of ITPR1 results in a decreased InsP(3) binding to the receptor (By similarity). Interacts with CACNA1A (via C-terminal CDB motif) in the pre- and postsynaptic membranes (By similarity). Interacts with CACNA1D and CACNA1C (via C-terminal C and IQ motifs). The binding to the C motif is calcium independent whereas the binding to IQ requires the presence of calcium and is mutually exclusive with calmodulin binding (By similarity). Interacts with TRPC5 (via C-terminus). Interacts (via EF- hands 1 and 2) at microtubules with MAP1LC3B (By similarity). Interacts with MYO1C. Interacts (via EF-hands 1 and 2) with NSMF (via the central NLS-containing motif region), the interaction occurs in a calcium dependent manner after synaptic NMDA receptor stimulation and prevents nuclear import of NSMF. Interacts with SPACA9 homolog. Event=Alternative splicing; Named isoforms=2; Name=L-CaBP1; IsoId=Q9JLK7-1; Sequence=Displayed; Name=S-CaBP1; IsoId=Q9JLK7-2; Sequence=VSP_000733; Expressed in the inner retina, specifically in amacrine cells and in cone OFF-bipolar cells (at protein level) (PubMed:27822497). EF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium cooperatively and EF-2 binds neither calcium nor magnesium. Phosphorylated. The phosphorylation regulates the activity (By similarity). Mice exhibit a normal retinal morphology but altered light responses of retinal ganglion cells (PubMed:27822497). Golgi membrane calcium ion binding protein binding plasma membrane visual perception nuclear localization sequence binding negative regulation of protein import into nucleus metal ion binding calcium-dependent protein binding response to stimulus modification of postsynaptic actin cytoskeleton glutamatergic synapse uc008zdg.1 uc008zdg.2 uc008zdg.3 
ENSMUST00000031521.13 Cyp2w1 ENSMUST00000031521.13 cytochrome P450, family 2, subfamily w, polypeptide 1 (from RefSeq NM_001160265.2) CP2W1_MOUSE E9Q816 ENSMUST00000031521.1 ENSMUST00000031521.10 ENSMUST00000031521.11 ENSMUST00000031521.12 ENSMUST00000031521.2 ENSMUST00000031521.3 ENSMUST00000031521.4 ENSMUST00000031521.5 ENSMUST00000031521.6 ENSMUST00000031521.7 ENSMUST00000031521.8 ENSMUST00000031521.9 NM_001160265 uc012efv.1 uc012efv.2 A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism. Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates. Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1- acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs). Has low or no activity toward 2- acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids. May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51984, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134178; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51985; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[8-hydroxy-(9Z)-octadecenoyl]-sn- glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50328, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:28610, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132285; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50329; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn- glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50332, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:28610, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132286; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50333; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9S,10R)-epoxy-octadecanoyl]-sn- glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50324, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:28610, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132278; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50325; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9R,10S)-epoxy-octadecanoyl]-sn- glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50320, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:28610, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132280; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50321; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum lumen Cell membrane Microsome membrane Detected in colon, ileum, and testes. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum lumen plasma membrane organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity cell surface membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding exogenous drug catabolic process intracellular membrane-bounded organelle aflatoxin B1 metabolic process metal ion binding oxidation-reduction process uc012efv.1 uc012efv.2 
ENSMUST00000031524.11 Acads ENSMUST00000031524.11 acyl-Coenzyme A dehydrogenase, short chain (from RefSeq NM_007383.3) ACADS_MOUSE ENSMUST00000031524.1 ENSMUST00000031524.10 ENSMUST00000031524.2 ENSMUST00000031524.3 ENSMUST00000031524.4 ENSMUST00000031524.5 ENSMUST00000031524.6 ENSMUST00000031524.7 ENSMUST00000031524.8 ENSMUST00000031524.9 NM_007383 Q07417 Q91W85 uc008zdb.1 uc008zdb.2 uc008zdb.3 This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the Acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum at C(four)-CoA. In mice, deficiency of this gene has been linked to cold sensitivity and increased high-density lipoprotein levels. [provided by RefSeq, Nov 2012]. Sequence Note: The transit peptide annotated at aa 1-24 is inferred by similarity to the cleavage site in the orthologous rat protein as described in PMID: 2777793. The software program TargetP1.1 predicts that the transit peptide in mouse is aa 1-48. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016259.1, AK155361.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains. Reaction=a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47196, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:87487, ChEBI:CHEBI:87488; EC=1.3.8.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47197; Evidence=; Reaction=butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:24004, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57332, ChEBI:CHEBI:57371, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307; EC=1.3.8.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24005; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl- CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:43456, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57389, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:86160; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43457; Evidence=; Reaction=H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:43464, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:62077, ChEBI:CHEBI:62620; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43465; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Lipid metabolism; mitochondrial fatty acid beta-oxidation. Homotetramer. Mitochondrion matrix Belongs to the acyl-CoA dehydrogenase family. fatty-acyl-CoA binding acyl-CoA dehydrogenase activity butyryl-CoA dehydrogenase activity nucleoplasm mitochondrion mitochondrial matrix lipid metabolic process fatty acid metabolic process oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors mitochondrial membrane fatty acid beta-oxidation using acyl-CoA dehydrogenase butyrate catabolic process flavin adenine dinucleotide binding protein homotetramerization oxidation-reduction process uc008zdb.1 uc008zdb.2 uc008zdb.3 
ENSMUST00000031530.9 Sppl3 ENSMUST00000031530.9 signal peptide peptidase 3 (from RefSeq NM_029012.2) E9QP88 ENSMUST00000031530.1 ENSMUST00000031530.2 ENSMUST00000031530.3 ENSMUST00000031530.4 ENSMUST00000031530.5 ENSMUST00000031530.6 ENSMUST00000031530.7 ENSMUST00000031530.8 Imp2 NM_029012 Psl4 Q8R597 Q9CUS9 SPPL3_MOUSE Sppl3 Usmg3 uc008zda.1 uc008zda.2 uc008zda.3 Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries. Acts like a sheddase by mediating the proteolytic release and secretion of active site- containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T- cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971). Its proteolytic activity is blocked by a signal peptide peptidase (SPP) inhibitor, (ZLL)2-ketone (ZLL) or a gamma- secretase inhibitor, LY411,575. Monomer. Homodimer (By similarity). Interacts with STIM1 (via transmembrane region and SOAR/CAD domain); the interaction promotes the binding of STIM1 to ORAI1 (PubMed:25384971). Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus Membrane ; Multi-pass membrane protein ; Lumenal side The first transmembrane domain may act as a type I signal anchor. The catalytic loops is exposed toward the lumen. The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family. Not glycosylated. Mice are viable but display growth retardation and haematologic abnormalities (PubMed:20562862). Male are sterile (PubMed:20562862). Exhibit hyperglycosylation of cellular glycoproteins (PubMed:25354954). Belongs to the peptidase A22B family. Sequence=BAB29515.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; aspartic-type endopeptidase activity protein binding endoplasmic reticulum endoplasmic reticulum membrane rough endoplasmic reticulum Golgi apparatus plasma membrane signal peptide processing proteolysis positive regulation of cytosolic calcium ion concentration peptidase activity membrane integral component of membrane hydrolase activity Golgi-associated vesicle membrane positive regulation of protein binding endoplasmic reticulum-Golgi intermediate compartment membrane membrane protein proteolysis positive regulation of protein dephosphorylation aspartic endopeptidase activity, intramembrane cleaving protein homodimerization activity intracellular membrane-bounded organelle T cell receptor signaling pathway positive regulation of calcineurin-NFAT signaling cascade integral component of cytoplasmic side of endoplasmic reticulum membrane integral component of lumenal side of endoplasmic reticulum membrane membrane protein ectodomain proteolysis uc008zda.1 uc008zda.2 uc008zda.3 
ENSMUST00000031531.14 Psmg3 ENSMUST00000031531.14 proteasome (prosome, macropain) assembly chaperone 3, transcript variant 1 (from RefSeq NM_025604.4) ENSMUST00000031531.1 ENSMUST00000031531.10 ENSMUST00000031531.11 ENSMUST00000031531.12 ENSMUST00000031531.13 ENSMUST00000031531.2 ENSMUST00000031531.3 ENSMUST00000031531.4 ENSMUST00000031531.5 ENSMUST00000031531.6 ENSMUST00000031531.7 ENSMUST00000031531.8 ENSMUST00000031531.9 NM_025604 PSMG3_MOUSE Pac3 Q9CZH3 uc009ahg.1 uc009ahg.2 uc009ahg.3 Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes. Homodimer. Interacts directly with alpha and beta subunits of the 20S proteasome but dissociates before the formation of half- proteasomes, probably upon recruitment of POMP (By similarity). Interacts with PSMG4. Belongs to the PSMG3 family. molecular_function biological_process uc009ahg.1 uc009ahg.2 uc009ahg.3 
ENSMUST00000031533.11 Tfec ENSMUST00000031533.11 transcription factor EC (from RefSeq NM_031198.3) ENSMUST00000031533.1 ENSMUST00000031533.10 ENSMUST00000031533.2 ENSMUST00000031533.3 ENSMUST00000031533.4 ENSMUST00000031533.5 ENSMUST00000031533.6 ENSMUST00000031533.7 ENSMUST00000031533.8 ENSMUST00000031533.9 NM_031198 Q3TWR7 Q9WTW4 TFEC_MOUSE Tcfec uc009aze.1 uc009aze.2 uc009aze.3 uc009aze.4 Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence) (By similarity). Binds to element F in an E-box sequence-specific manner (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. Homodimer. Forms heterodimers with MITF. Interacts with MITF. Forms heterodimers with TFE3 (By similarity). Nucleus Expressed in osteoclast-like cells (at protein level). Expressed in cells of the mononuclear phagocyte lineage. Expressed in macrophages and in osteoclast-like cells. Expressed in the early developing retinal pigmented epithelium and in the peripheral retina. Up-regulated in bone marrow-derived macrophages by Th2 cytokines, IL-4, IL-13 and LPS. Contains an activation domain in the C-terminal region. Belongs to the MiT/TFE family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated cellular response to heat positive regulation of transcription from RNA polymerase II promoter protein dimerization activity uc009aze.1 uc009aze.2 uc009aze.3 uc009aze.4 
ENSMUST00000031534.9 Mad1l1 ENSMUST00000031534.9 MAD1 mitotic arrest deficient 1-like 1, transcript variant 1 (from RefSeq NM_010752.3) ENSMUST00000031534.1 ENSMUST00000031534.2 ENSMUST00000031534.3 ENSMUST00000031534.4 ENSMUST00000031534.5 ENSMUST00000031534.6 ENSMUST00000031534.7 ENSMUST00000031534.8 MD1L1_MOUSE Mad1 NM_010752 Q9WTX8 Q9WTX9 uc009ahj.1 uc009ahj.2 Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (By similarity). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (By similarity). Homodimer (By similarity). Dimerizes via its N- and C- terminal regions (By similarity). Heterodimerizes with MAD2L1 in order to form a tetrameric MAD1L1-MAD2L1 core complex (By similarity). Interacts with the closed conformation form of MAD2L1 (C-MAD2) and open conformation form of MAD2L1 (O-MAD2) (By similarity). It is unclear whether MAD1L1 dimerization promotes the conversion of closed to open conformation of MAD2L1 (By similarity). Formation of a heterotetrameric core complex containing two molecules each of MAD1L1 and of MAD2L1 promotes binding of another molecule of MAD2L1 to each MAD2L1, resulting in a heterohexamer (By similarity). Perturbation of the original MAD1L1-MAD2L1 structure by the spindle checkpoint may decrease MAD2L1 affinity for MAD1L1 (By similarity). CDC20 can compete with MAD1L1 for MAD2L1 binding, until the attachment and/or tension dampen the checkpoint signal, preventing further release of MAD2L1 on to CDC20 (By similarity). Also able to interact with the BUB1/BUB3 complex (By similarity). Interacts with NEK2 (By similarity). Interacts with TTK (By similarity). Interacts with TPR; the interactions occurs in a microtubule-independent manner (By similarity). Interacts with IK (By similarity). Interacts with the viral Tax protein (By similarity). Interacts with PRAP1 (By similarity). Q9WTX8; O35231: Kifc3; NbExp=3; IntAct=EBI-4285225, EBI-11097964; Nucleus Chromosome, centromere, kinetochore Nucleus envelope Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=Detected at the nucleus envelope during interphase. From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Detected at kinetochores during prometaphase. Colocalizes with NEK2 at the kinetochore. Colocalizes with IK at spindle poles during metaphase and anaphase. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=MAD1a; IsoId=Q9WTX8-1; Sequence=Displayed; Name=2; Synonyms=MAD1b; IsoId=Q9WTX8-2; Sequence=VSP_011638; Phosphorylated; by BUB1. Become hyperphosphorylated in late S through M phases or after mitotic spindle damage. Belongs to the MAD1 family. chromosome, centromeric region kinetochore condensed chromosome kinetochore spindle pole nucleus nuclear envelope chromosome cytoplasm microtubule organizing center spindle cytoskeleton cell cycle mitotic spindle assembly checkpoint negative regulation of T cell proliferation identical protein binding kinetochore binding nuclear pore nuclear basket thymus development cell division attachment of mitotic spindle microtubules to kinetochore mitotic spindle regulation of metaphase plate congression mitotic spindle pole regulation of mitotic cell cycle phase transition uc009ahj.1 uc009ahj.2 
ENSMUST00000031535.12 Hnf1a ENSMUST00000031535.12 HNF1 homeobox A (from RefSeq NM_009327.3) E9QP86 ENSMUST00000031535.1 ENSMUST00000031535.10 ENSMUST00000031535.11 ENSMUST00000031535.2 ENSMUST00000031535.3 ENSMUST00000031535.4 ENSMUST00000031535.5 ENSMUST00000031535.6 ENSMUST00000031535.7 ENSMUST00000031535.8 ENSMUST00000031535.9 HNF1A_MOUSE Hnf-1 Hnf-1a NM_009327 P22361 Tcf1 uc008zcz.1 uc008zcz.2 uc008zcz.3 uc008zcz.4 This gene encodes a hepatic transcription factor. The encoded protein is not a member of the T-cell factor family, and is distinct from T-cell specific transcription factor 7 which has also been referred to by the symbol Tcf1. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC080698.1, AK144051.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849389 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (PubMed:19289501). Binds to the inverted palindrome 5'- GTTAATNATTAAC-3' (PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (PubMed:30555544). Binds DNA as a dimer (PubMed:11106484, PubMed:11439029). Heterotetramer with PCBD1; formed by a dimer of dimers (PubMed:10966642). Interacts with PCBD1 (By similarity). Interacts with BHLHE41 (PubMed:30555544). P22361; Q923E4: Sirt1; NbExp=5; IntAct=EBI-5272860, EBI-1802585; Nucleus. Liver. Mice are born at less than half of the expected frequency. Neonates are slightly smaller than normal and do not grow normally. After 5 weeks mice weigh only 50 to 60% as much as their littermates. Mice develop non-insulin-dependent diabetes mellitus (NIDDM) 2 weeks after birth. Mice exhibit elevated levels of blood glucose, combined with reduced blood levels of insulin and insulin-like growth factor I (IGFI). Males and females are sterile. Belongs to the HNF1 homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding photoreceptor outer segment natural killer cell differentiation blastocyst development liver development placenta development DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter fatty acid biosynthetic process bile acid biosynthetic process heme biosynthetic process response to oxidative stress protein localization transcription factor binding cholesterol metabolic process response to glucose bile acid and bile salt transport fatty acid transport histone acetylation insulin secretion regulation of Wnt signaling pathway embryonic limb morphogenesis pancreas development endocrine pancreas development macromolecular complex renal glucose absorption glucose homeostasis protein homodimerization activity sequence-specific DNA binding reverse cholesterol transport transcription regulatory region DNA binding pronucleus bone resorption positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter glucose import regulation of hormone secretion protein heterodimerization activity protein dimerization activity paraxial mesoderm formation reproductive structure development positive regulation of transcription initiation from RNA polymerase II promoter SMAD protein signal transduction uc008zcz.1 uc008zcz.2 uc008zcz.3 uc008zcz.4 
ENSMUST00000031536.8 Mrm2 ENSMUST00000031536.8 mitochondrial rRNA methyltransferase 2 (from RefSeq NM_026510.1) ENSMUST00000031536.1 ENSMUST00000031536.2 ENSMUST00000031536.3 ENSMUST00000031536.4 ENSMUST00000031536.5 ENSMUST00000031536.6 ENSMUST00000031536.7 Ftsj2 MRM2_MOUSE Mrm2 NM_026510 Q9CPY0 uc009ahm.1 uc009ahm.2 S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Reaction=S-adenosyl-L-methionine + uridine(1369) in 16S rRNA = 2'-O- methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:47764, Rhea:RHEA-COMP:11903, Rhea:RHEA-COMP:11904, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65315, ChEBI:CHEBI:74478; Evidence=; Mitochondrion Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RNA methylation nucleolus mitochondrion rRNA processing methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity transferase activity rRNA methylation methylation uc009ahm.1 uc009ahm.2 
ENSMUST00000031538.9 2210016L21Rik ENSMUST00000031538.9 RIKEN cDNA 2210016L21 gene (from RefSeq NM_028211.1) 2210016L21Rik A0A0R4J099 A0A0R4J099_MOUSE ENSMUST00000031538.1 ENSMUST00000031538.2 ENSMUST00000031538.3 ENSMUST00000031538.4 ENSMUST00000031538.5 ENSMUST00000031538.6 ENSMUST00000031538.7 ENSMUST00000031538.8 NM_028211 uc008zcy.1 uc008zcy.2 uc008zcy.3 Belongs to the CUSTOS family. Wnt signaling pathway uc008zcy.1 uc008zcy.2 uc008zcy.3 
ENSMUST00000031539.12 Snx8 ENSMUST00000031539.12 sorting nexin 8 (from RefSeq NM_172277.3) ENSMUST00000031539.1 ENSMUST00000031539.10 ENSMUST00000031539.11 ENSMUST00000031539.2 ENSMUST00000031539.3 ENSMUST00000031539.4 ENSMUST00000031539.5 ENSMUST00000031539.6 ENSMUST00000031539.7 ENSMUST00000031539.8 ENSMUST00000031539.9 NM_172277 Q8BLI6 Q8BUQ7 Q8CFD4 SNX8_MOUSE uc009ahq.1 uc009ahq.2 uc009ahq.3 May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (By similarity). Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Colocalizes with retromer components. Belongs to the sorting nexin family. Sequence=BAC32202.1; Type=Erroneous initiation; Evidence=; Sequence=BAE28549.1; Type=Erroneous initiation; Evidence=; endosome cytosol intracellular protein transport lipid binding protein transport membrane retromer complex early endosome membrane early endosome to Golgi transport phosphatidylinositol binding retrograde transport, endosome to Golgi identical protein binding intracellular membrane-bounded organelle uc009ahq.1 uc009ahq.2 uc009ahq.3 
ENSMUST00000031540.11 Oasl1 ENSMUST00000031540.11 2'-5' oligoadenylate synthetase-like 1, transcript variant 2 (from RefSeq NM_145209.3) ENSMUST00000031540.1 ENSMUST00000031540.10 ENSMUST00000031540.2 ENSMUST00000031540.3 ENSMUST00000031540.4 ENSMUST00000031540.5 ENSMUST00000031540.6 ENSMUST00000031540.7 ENSMUST00000031540.8 ENSMUST00000031540.9 NM_145209 OASL1_MOUSE Q3UBP8 Q8K2A2 Q8QZV5 Q8VI94 oasl9 uc008zcv.1 uc008zcv.2 uc008zcv.3 Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L. Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14 does not require the presence of thyroid hormone for its interaction. Binds MBD1 (By similarity). Nucleus, nucleolus Cytoplasm By type I interferon (IFN) and viruses. Belongs to the 2-5A synthase family. Sequence=BAE29916.1; Type=Frameshift; Evidence=; immune system process DNA binding RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm nucleolus cytoplasm cytosol immune response response to virus transferase activity negative regulation of viral genome replication innate immune response defense response to virus regulation of ribonuclease activity 2'-5'-oligoadenylate synthetase activity uc008zcv.1 uc008zcv.2 uc008zcv.3 
ENSMUST00000031542.13 Oasl2 ENSMUST00000031542.13 2'-5' oligoadenylate synthetase-like 2, transcript variant 1 (from RefSeq NM_011854.2) ENSMUST00000031542.1 ENSMUST00000031542.10 ENSMUST00000031542.11 ENSMUST00000031542.12 ENSMUST00000031542.2 ENSMUST00000031542.3 ENSMUST00000031542.4 ENSMUST00000031542.5 ENSMUST00000031542.6 ENSMUST00000031542.7 ENSMUST00000031542.8 ENSMUST00000031542.9 NM_011854 OASL2_MOUSE Q9D6S2 Q9Z2F2 uc008zcu.1 uc008zcu.2 uc008zcu.3 Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Reaction=3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')- adenosine + 2 diphosphate; Xref=Rhea:RHEA:34407, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:67143; EC=2.7.7.84; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:34408; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is tolerated. ssRNA or dsDNA do not act as activators. Kinetic parameters: KM=0.66 mM for ATP ; Note=kcat is 0.39 sec(-1) with ATP as substrate. ; Strongly expressed in spleen dendritic cells, whereas, in bone marrow-derived dendritic cells, the amount increases during the maturation process. Expressed in many organs, the highest levels being in thymus, lung, and bone marrow. Belongs to the 2-5A synthase family. nucleotide binding 2'-5'-oligoadenylate synthetase activity immune system process RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm cytosol purine nucleotide biosynthetic process immune response response to virus transferase activity nucleotidyltransferase activity negative regulation of viral genome replication innate immune response metal ion binding defense response to virus regulation of ribonuclease activity uc008zcu.1 uc008zcu.2 uc008zcu.3 
ENSMUST00000031549.6 Iigp1c ENSMUST00000031549.6 interferon inducible GTPase 1C (from RefSeq NM_001033767.3) EG240327 ENSMUST00000031549.1 ENSMUST00000031549.2 ENSMUST00000031549.3 ENSMUST00000031549.4 ENSMUST00000031549.5 Gm4951 Ifgga2 Iigp1c NM_001033767 Q3UED7 Q3UED7_MOUSE uc008ezy.1 uc008ezy.2 uc008ezy.3 uc008ezy.4 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. GTPase activity GTP binding endoplasmic reticulum membrane defense response membrane cellular response to interferon-beta uc008ezy.1 uc008ezy.2 uc008ezy.3 uc008ezy.4 
ENSMUST00000031554.9 Tmem168 ENSMUST00000031554.9 transmembrane protein 168, transcript variant 1 (from RefSeq NM_028990.5) ENSMUST00000031554.1 ENSMUST00000031554.2 ENSMUST00000031554.3 ENSMUST00000031554.4 ENSMUST00000031554.5 ENSMUST00000031554.6 ENSMUST00000031554.7 ENSMUST00000031554.8 NM_028990 Q3TDA5 Q91VX9 TM168_MOUSE uc009ayn.1 uc009ayn.2 uc009ayn.3 Plays a key role in maintaining the cardiac electrical stability by modulating cell surface expression of SCN5A (PubMed:32175648). Plays a role i the modulation of anxiety behavior by regulating GABAergic neuronal system in the nucleus accumbens (PubMed:29211814). Nucleus membrane ; Multi-pass membrane protein Belongs to the TMEM168 family. molecular_function biological_process membrane integral component of membrane transport vesicle uc009ayn.1 uc009ayn.2 uc009ayn.3 
ENSMUST00000031555.3 Lfng ENSMUST00000031555.3 LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (from RefSeq NM_008494.3) ENSMUST00000031555.1 ENSMUST00000031555.2 LFNG_MOUSE Lfng NM_008494 O09010 Q3U659 Q8K3F1 Q9DC10 uc009ahu.1 uc009ahu.2 uc009ahu.3 Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (PubMed:28089369, PubMed:16385447). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (By similarity). Essential mediator of somite segmentation and patterning. During somite boundary formation, it restricts Notch activity in the presomitic mesoderm to a boundary- forming territory in the posterior half of the prospective somite. In this region, Notch function activates a set of genes that are involved in boundary formation and in anterior-posterior somite identity (PubMed:10330372). Ectopically expressed in the thymus, Lfgn inhibits Notch signaling which results in inhibition of T-cell commitment and promotes B-cell development in lymphoid progenitors (PubMed:11520458). May play a role in boundary formation of the enamel knot (PubMed:12167404). Reaction=3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl- (1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:70531, Rhea:RHEA-COMP:17922, Rhea:RHEA- COMP:17923, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:189631, ChEBI:CHEBI:189634; EC=2.4.1.222; Evidence=; Reaction=3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP- N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl- (1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:70511, Rhea:RHEA-COMP:17919, Rhea:RHEA- COMP:17920, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:189632, ChEBI:CHEBI:189633; EC=2.4.1.222; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Note=Manganese is the most effective. Can also use cobalt with lower efficiency. Has some activity with magnesium and calcium, but not zinc. ; Kinetic parameters: KM=78 uM for UDP-N-acetyl-alpha-D-glucosamine ; Vmax=20 nmol/min/mg enzyme ; pH dependence: Optimum pH is 5. ; Temperature dependence: Optimum temperature is 37 degrees Celsius. ; Golgi apparatus Golgi apparatus membrane ; Single-pass type II membrane protein Detected at 12.5 dpc in all tissues examined with the highest level observed in adult brain and spleen. Detected in the dental epithelium. Developmental protein. During segmentation it shows a cyclic transcription pattern which is under the control of Notch. Expressed in the caudal region of the presomitic mesoderm with each cycle corresponding to the formation time of one somite. In the dental epithelium it is detected at stage 13.5 dpc. The pattern of expression corresponds exactly to the formation of the enamel knot between late bud and early cap stages. A soluble form may be derived from the membrane form by proteolytic processing. Belongs to the glycosyltransferase 31 family. Name=Functional Glycomics Gateway - GTase; Note=lunatic fringe gene homolog (lfng); URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_590"; Golgi membrane ovarian follicle development somitogenesis marginal zone B cell differentiation Golgi apparatus multicellular organism development compartment pattern specification pattern specification process regulation of Notch signaling pathway regulation of somitogenesis membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups integral component of Golgi membrane T cell differentiation positive regulation of protein binding O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity protein O-linked fucosylation positive regulation of Notch signaling pathway metal ion binding positive regulation of meiotic cell cycle negative regulation of Notch signaling pathway involved in somitogenesis uc009ahu.1 uc009ahu.2 uc009ahu.3 
ENSMUST00000031556.14 Tmem106b ENSMUST00000031556.14 transmembrane protein 106B (from RefSeq NM_027992.3) ENSMUST00000031556.1 ENSMUST00000031556.10 ENSMUST00000031556.11 ENSMUST00000031556.12 ENSMUST00000031556.13 ENSMUST00000031556.2 ENSMUST00000031556.3 ENSMUST00000031556.4 ENSMUST00000031556.5 ENSMUST00000031556.6 ENSMUST00000031556.7 ENSMUST00000031556.8 ENSMUST00000031556.9 NM_027992 Q80X71 Q9D737 T106B_MOUSE uc009ayk.1 uc009ayk.2 uc009ayk.3 uc009ayk.4 In neurons, involved in the transport of late endosomes/lysosomes (PubMed:25066864, PubMed:32160553). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:25066864). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (PubMed:32160553). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is particularly important in the sorting of lysosomes in axons or in dendrites (Probable). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (PubMed:25066864). Required for proper lysosomal acidification (PubMed:28728022). Can form homomers (By similarity). Interacts (via N-terminus) with MAP6 (via C-terminus) (By similarity). Interacts (via C-terminus) with the vacuolar-type ATPase subunit ATP6AP1 (By similarity). Interacts (via N-terminus) with AP2M1 and CLTC (By similarity). Interacts with TMEM106C (By similarity). Late endosome membrane ; Single-pass type II membrane protein. Lysosome membrane ; Single-pass type II membrane protein. Cell membrane ; Single-pass type II membrane protein Note=Colocalizes with LAMP1. A small fraction resides on the cell surface (By similarity). Expressed in the brain, in neurons (at protein level) (PubMed:25066864, PubMed:28728022, PubMed:29855382, PubMed:32160553, PubMed:32761777). Expressed in the spinal cord (at protein level) (PubMed:32160553). Knockout mice are born at the expected Mendelian ratio and young animals appear phenotypically normal (PubMed:28728022, PubMed:29855382, PubMed:32160553, PubMed:32852886). At 10 weeks of age, knockout mice develop proximal axonal swellings caused by drastically enlarged LAMP1-positive vacuoles (lysosomes/endosomes), increased retrograde axonal transport of lysosomes, and accumulation of lipofuscin and autophagosomes. Giant vacuoles specifically accumulate at the distal end and within the axon initial segment, but not in peripheral nerves or at axon terminals, resulting in an impaired facial-nerve-dependent motor performance (PubMed:32160553, PubMed:32852886). Using a different experimental approach to create the knockout, a more subtle, exclusively lysosomal phenotype is observed. At 2 months of age, numerous lysosomal proteins, including cathepsin B/CTSB, cathepsin L/CTSL, dipeptidyl peptidase 2/DPP7, LAMP1 and vacuolar-type ATPase subunits, are down-regulated and lysosomal acidification is impaired (PubMed:28728022). It has been suggested that these phenotypic differences might be due to incomplete knockout in animals with milder phenotypes (PubMed:32160553). Mice deficient in both PGRN and TMEM106B are born at normal Mendelian frequency and do not show any obvious growth defects or body weight changes. At around 3.5 months of age, the animals develop severe ataxia, hindlimb weakness, reduced motor activity, altered clasping behavior and eventually premature death. Neuronal loss and severe microglia and astrocyte activation are observed in the spinal cord, retina, and brain (PubMed:32761777, PubMed:32852886, PubMed:32929860). Myelin degeneration occurs in the spinal cord (PubMed:32761777). Drastic autophagy and lysosomal abnormalities, as well as other pathological changes related to frontotemporal lobar degeneration (FTLD)/amyotrophic lateral sclerosis are observed (PubMed:32761777, PubMed:32852886, PubMed:32929860). Most studies consistently show that loss of TMEM106B exacerbates lysosome abnormalities found in GRN-single knockout animals, likely contributing to neuronal dysfunction and neuronal death (PubMed:32761777, PubMed:32852886, PubMed:32929860). However, one study reports that the expression levels of most lysosomal proteins are normalized in double knockout mice and comparable to those of wild-type animals and some behavioral phenotypes observed in GRN-single knockout mice, such as locomotor hyperactivity and disinhibition, are rescued in double knockout (PubMed:28728022). TMEM106B knockout does not rescue FTLD-like phenotypes in a mouse model mimicking the toxic gain-of- functions associated with overexpression of hexanucleotide repeat (GGGGCC) expansions in C9ORF72 (PubMed:29855382). Belongs to the TMEM106 family. molecular_function lysosome lysosomal membrane endosome lysosome organization lysosomal transport membrane integral component of membrane late endosome membrane lysosome localization dendrite morphogenesis positive regulation of dendrite development uc009ayk.1 uc009ayk.2 uc009ayk.3 uc009ayk.4 
ENSMUST00000031560.14 Mmab ENSMUST00000031560.14 methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human), transcript variant 1 (from RefSeq NM_029956.4) ENSMUST00000031560.1 ENSMUST00000031560.10 ENSMUST00000031560.11 ENSMUST00000031560.12 ENSMUST00000031560.13 ENSMUST00000031560.2 ENSMUST00000031560.3 ENSMUST00000031560.4 ENSMUST00000031560.5 ENSMUST00000031560.6 ENSMUST00000031560.7 ENSMUST00000031560.8 ENSMUST00000031560.9 MMAB_MOUSE Mmab NM_029956 Q3UFL6 Q8CBZ0 Q8VBZ4 Q9D273 uc008yzo.1 uc008yzo.2 uc008yzo.3 Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA. Reaction=ATP + cob(I)alamin-[corrinoid adenosyltransferase] = adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate; Xref=Rhea:RHEA:56796, Rhea:RHEA-COMP:14743, Rhea:RHEA- COMP:14744, ChEBI:CHEBI:18036, ChEBI:CHEBI:18408, ChEBI:CHEBI:30616, ChEBI:CHEBI:60488, ChEBI:CHEBI:83228; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56797; Evidence=; Homotrimer. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D273-1; Sequence=Displayed; Name=2; IsoId=Q9D273-2; Sequence=VSP_008847; [Isoform 2]: Due to intron retention. Belongs to the Cob(I)alamin adenosyltransferase family. nucleotide binding ATP binding mitochondrion cob(I)yrinic acid a,c-diamide adenosyltransferase activity cobalamin metabolic process cobalamin biosynthetic process transferase activity cobalamin binding uc008yzo.1 uc008yzo.2 uc008yzo.3 
ENSMUST00000031565.15 Fscn1 ENSMUST00000031565.15 fascin actin-bundling protein 1 (from RefSeq NM_007984.2) ENSMUST00000031565.1 ENSMUST00000031565.10 ENSMUST00000031565.11 ENSMUST00000031565.12 ENSMUST00000031565.13 ENSMUST00000031565.14 ENSMUST00000031565.2 ENSMUST00000031565.3 ENSMUST00000031565.4 ENSMUST00000031565.5 ENSMUST00000031565.6 ENSMUST00000031565.7 ENSMUST00000031565.8 ENSMUST00000031565.9 FSCN1_MOUSE Fan1 NM_007984 O09099 O09156 Q05DK3 Q61553 Q7TN32 Q80V75 Snl uc009ajl.1 uc009ajl.2 uc009ajl.3 Actin-binding protein that contains 2 major actin binding sites (By similarity). Organizes filamentous actin into parallel bundles (PubMed:7738015). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (By similarity). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:21685497). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (By similarity). Interacts with RUFY3 (via N-terminus); the interaction induces neuron axon development (PubMed:24720729). Interacts with NGFR (By similarity). Associates with CTNNB1 (PubMed:8794867). Interacts with PLXNB3 (PubMed:21706053). Q61553; Q9QY40: Plxnb3; NbExp=3; IntAct=EBI-2308857, EBI-6271317; Q61553; P68135: ACTA1; Xeno; NbExp=2; IntAct=EBI-2308857, EBI-367540; Cytoplasm, cytosol Cytoplasm, cell cortex Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, stress fiber Cell projection, growth cone Cell projection, filopodium ll projection, invadopodium Cell projection, microvillus Cell junction Note=Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone (PubMed:24720729). Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (PubMed:24720729). Most abundant in brain. Detected at lower levels in lung, uterus, small intestine and spleen (at protein level). Composed of four fascin beta-trefoil domains. Phosphorylation at Ser-39 inhibits actin-binding. Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF. Belongs to the fascin family. stress fiber ruffle podosome actin binding protein binding cytoplasm cytosol cytoskeleton plasma membrane microvillus cell-cell junction cell cortex actin filament organization cell-cell junction assembly establishment or maintenance of cell polarity drug binding positive regulation of lamellipodium assembly actin cytoskeleton cell migration lamellipodium microspike assembly actin cytoskeleton organization parallel actin filament bundle assembly cell junction filopodium dendrite growth cone protein binding, bridging cell projection membrane regulation of microvillus assembly regulation of actin cytoskeleton organization establishment of apical/basal cell polarity cell projection myelin sheath microspike cell motility actin filament binding actin filament bundle assembly positive regulation of filopodium assembly invadopodium positive regulation of podosome assembly positive regulation of extracellular matrix disassembly uc009ajl.1 uc009ajl.2 uc009ajl.3 
ENSMUST00000031574.10 Spdye4b ENSMUST00000031574.10 speedy/RINGO cell cycle regulator family, member E4B, transcript variant 2 (from RefSeq NM_177880.4) 4933411G11Rik ENSMUST00000031574.1 ENSMUST00000031574.2 ENSMUST00000031574.3 ENSMUST00000031574.4 ENSMUST00000031574.5 ENSMUST00000031574.6 ENSMUST00000031574.7 ENSMUST00000031574.8 ENSMUST00000031574.9 NM_177880 Q8CDE8 Q8CDE8_MOUSE Spdyb Spdye4 Spdye4b uc009ajr.1 uc009ajr.2 uc009ajr.3 Belongs to the Speedy/Ringo family. cellular_component protein kinase binding uc009ajr.1 uc009ajr.2 uc009ajr.3 
ENSMUST00000031587.13 Ung ENSMUST00000031587.13 uracil DNA glycosylase, transcript variant 1 (from RefSeq NM_001040691.1) ENSMUST00000031587.1 ENSMUST00000031587.10 ENSMUST00000031587.11 ENSMUST00000031587.12 ENSMUST00000031587.2 ENSMUST00000031587.3 ENSMUST00000031587.4 ENSMUST00000031587.5 ENSMUST00000031587.6 ENSMUST00000031587.7 ENSMUST00000031587.8 ENSMUST00000031587.9 NM_001040691 P97285 P97509 P97931 Q7TPW8 Q9JIW8 UNG_MOUSE Ung1 uc008yzf.1 uc008yzf.2 uc008yzf.3 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Reaction=Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.27; Evidence=; Monomer. Interacts with FAM72A. [Isoform 1]: Mitochondrion. [Isoform 2]: Nucleus. Event=Alternative splicing; Named isoforms=2; Name=2; Synonyms=UNG2; IsoId=P97931-1; Sequence=Displayed; Name=1; Synonyms=UNG1; IsoId=P97931-2; Sequence=VSP_008514; Isoform 1 is processed by cleavage of a transit peptide. Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. damaged DNA binding uracil DNA N-glycosylase activity nucleus nucleoplasm mitochondrion DNA repair base-excision repair cellular response to DNA damage stimulus somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments hydrolase activity hydrolase activity, hydrolyzing N-glycosyl compounds ribosomal small subunit binding negative regulation of apoptotic process isotype switching base-excision repair, AP site formation via deaminated base removal uc008yzf.1 uc008yzf.2 uc008yzf.3 
ENSMUST00000031588.12 Usp30 ENSMUST00000031588.12 ubiquitin specific peptidase 30, transcript variant 7 (from RefSeq NR_184658.1) ENSMUST00000031588.1 ENSMUST00000031588.10 ENSMUST00000031588.11 ENSMUST00000031588.2 ENSMUST00000031588.3 ENSMUST00000031588.4 ENSMUST00000031588.5 ENSMUST00000031588.6 ENSMUST00000031588.7 ENSMUST00000031588.8 ENSMUST00000031588.9 NR_184658 Q3TS48 Q3TSB9 Q3UN04 Q8BVI3 Q8CHW7 UBP30_MOUSE uc008yzc.1 uc008yzc.2 uc008yzc.3 Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys- 6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (By similarity). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (PubMed:24513856). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Inhibited by the diterpenoid derivative 15- oxospiramilactone (S3). Mitochondrion outer membrane Ubiquitinated by parkin (PRKN) at Lys-235 and Lys-289, leading to its degradation. Belongs to the peptidase C19 family. Sequence=AAH38606.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; mitophagy cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding mitochondrion mitochondrial outer membrane proteolysis ubiquitin-dependent protein catabolic process mitochondrial fusion peptidase activity cysteine-type peptidase activity membrane integral component of membrane protein deubiquitination hydrolase activity protein K11-linked deubiquitination thiol-dependent ubiquitinyl hydrolase activity protein K6-linked deubiquitination negative regulation of macromitophagy uc008yzc.1 uc008yzc.2 uc008yzc.3 
ENSMUST00000031590.12 Rbm19 ENSMUST00000031590.12 RNA binding motif protein 19 (from RefSeq NM_028762.1) ENSMUST00000031590.1 ENSMUST00000031590.10 ENSMUST00000031590.11 ENSMUST00000031590.2 ENSMUST00000031590.3 ENSMUST00000031590.4 ENSMUST00000031590.5 ENSMUST00000031590.6 ENSMUST00000031590.7 ENSMUST00000031590.8 ENSMUST00000031590.9 NM_028762 Q8BHR0 Q8R3C6 Q9CW63 RBM19_MOUSE uc008zha.1 uc008zha.2 uc008zha.3 Plays a role in embryo pre-implantation development. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Chromosome. Note=Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to nucleolar precursor body (NPB) (By similarity). In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the NPB. During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R3C6-1; Sequence=Displayed; Name=2; IsoId=Q8R3C6-2; Sequence=VSP_015005, VSP_015006; Expressed in the crypts of Lieberkuhn of the intestine (at protein level). Expressed during early development. Expressed in the epithelium of the embryonic gut tube (at protein level). Arrests embryonic development prior to implantation. Embryos at 3.5 dpc lack the mature, tripartite nucleoli, but instead, contain spheres resembling nucleolar precursor body (NPB), indicating arrest of nucleologenesis. Belongs to the RRM MRD1 family. regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus nucleoplasm chromosome nucleolus cytoplasm multicellular organism development nuclear speck positive regulation of embryonic development mRNA cis splicing, via spliceosome uc008zha.1 uc008zha.2 uc008zha.3 
ENSMUST00000031591.10 Lhx5 ENSMUST00000031591.10 LIM homeobox protein 5 (from RefSeq NM_008499.5) ENSMUST00000031591.1 ENSMUST00000031591.2 ENSMUST00000031591.3 ENSMUST00000031591.4 ENSMUST00000031591.5 ENSMUST00000031591.6 ENSMUST00000031591.7 ENSMUST00000031591.8 ENSMUST00000031591.9 Lhx5 NM_008499 Q543P4 Q543P4_MOUSE uc012ecn.1 uc012ecn.2 uc012ecn.3 Nucleus DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc012ecn.1 uc012ecn.2 uc012ecn.3 
ENSMUST00000031594.13 Sdsl ENSMUST00000031594.13 serine dehydratase-like, transcript variant 2 (from RefSeq NM_001384254.1) ENSMUST00000031594.1 ENSMUST00000031594.10 ENSMUST00000031594.11 ENSMUST00000031594.12 ENSMUST00000031594.2 ENSMUST00000031594.3 ENSMUST00000031594.4 ENSMUST00000031594.5 ENSMUST00000031594.6 ENSMUST00000031594.7 ENSMUST00000031594.8 ENSMUST00000031594.9 NM_001384254 Q8R238 Q8VI05 SDSL_MOUSE Sds uc008zhf.1 uc008zhf.2 Has low serine dehydratase and threonine dehydratase activity. Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169, ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17; Reaction=L-threonine = 2-oxobutanoate + NH4(+); Xref=Rhea:RHEA:22108, ChEBI:CHEBI:16763, ChEBI:CHEBI:28938, ChEBI:CHEBI:57926; EC=4.3.1.19; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Homodimer. Abundantly expressed in liver. Belongs to the serine/threonine dehydratase family. Sequence=AAL56988.1; Type=Frameshift; Evidence=; L-serine ammonia-lyase activity L-threonine ammonia-lyase activity mitochondrion L-serine catabolic process threonine catabolic process lyase activity identical protein binding uc008zhf.1 uc008zhf.2 
ENSMUST00000031597.7 Plbd2 ENSMUST00000031597.7 phospholipase B domain containing 2 (from RefSeq NM_023625.4) ENSMUST00000031597.1 ENSMUST00000031597.2 ENSMUST00000031597.3 ENSMUST00000031597.4 ENSMUST00000031597.5 ENSMUST00000031597.6 NM_023625 PLBL2_MOUSE Q3TCN2 Q3TD43 Q3TPP8 Q8BHG8 Q8BMB6 Q8BXI3 Q8C0M4 Q8R0V3 Q9DBG4 Q9EQI9 uc008zhh.1 uc008zhh.2 uc008zhh.3 uc008zhh.4 Putative phospholipase. Interacts with IGF2R. Lysosome lumen Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TCN2-1; Sequence=Displayed; Name=2; IsoId=Q3TCN2-2; Sequence=VSP_024998, VSP_024999; Present at highest levels in spleen, lung and brain (at protein level). The p76 protein is synthesized as a 76 kDa precursor which is then processed into a N-terminal 28 kDa form and a C-terminal 40 kDa form. The C-terminal peptide is further processed into a 15 kDa form. Glycosylated; contains mannose 6-phosphate sugars. Belongs to the phospholipase B-like family. Sequence=AAH26395.1; Type=Erroneous initiation; Evidence=; molecular_function phospholipase activity lysosome lipid metabolic process biological_process lipid catabolic process hydrolase activity lysosomal lumen uc008zhh.1 uc008zhh.2 uc008zhh.3 uc008zhh.4 
ENSMUST00000031598.11 Ddx54 ENSMUST00000031598.11 DEAD box helicase 54, transcript variant 2 (from RefSeq NR_184579.1) DDX54_MOUSE ENSMUST00000031598.1 ENSMUST00000031598.10 ENSMUST00000031598.2 ENSMUST00000031598.3 ENSMUST00000031598.4 ENSMUST00000031598.5 ENSMUST00000031598.6 ENSMUST00000031598.7 ENSMUST00000031598.8 ENSMUST00000031598.9 NR_184579 Q8K4L0 uc008zhq.1 uc008zhq.2 uc008zhq.3 Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Interacts in a hormone-dependent manner with nuclear receptors. Nucleus, nucleolus Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. nucleotide binding nucleic acid binding transcription corepressor activity RNA binding RNA helicase activity helicase activity receptor binding ATP binding nucleus nucleolus Golgi apparatus rRNA processing RNA processing RNA metabolic process hydrolase activity estrogen receptor binding negative regulation of nucleic acid-templated transcription uc008zhq.1 uc008zhq.2 uc008zhq.3 
ENSMUST00000031606.10 Rasal1 ENSMUST00000031606.10 RAS protein activator like 1 (GAP1 like), transcript variant 1 (from RefSeq NM_013832.5) ENSMUST00000031606.1 ENSMUST00000031606.2 ENSMUST00000031606.3 ENSMUST00000031606.4 ENSMUST00000031606.5 ENSMUST00000031606.6 ENSMUST00000031606.7 ENSMUST00000031606.8 ENSMUST00000031606.9 NM_013832 Q99K69 Q9Z268 RASL1_MOUSE Rasal Rasal1 uc008zhr.1 uc008zhr.2 uc008zhr.3 uc008zhr.4 Probable inhibitory regulator of the Ras-cyclic AMP pathway. Plays a role in dendrite formation by melanocytes. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; GTPase activator activity phospholipid binding cytosol plasma membrane signal transduction cell differentiation intracellular signal transduction regulation of GTPase activity positive regulation of GTPase activity negative regulation of Ras protein signal transduction metal ion binding cellular response to calcium ion positive regulation of dendrite extension uc008zhr.1 uc008zhr.2 uc008zhr.3 uc008zhr.4 
ENSMUST00000031607.7 Dtx1 ENSMUST00000031607.7 deltex 1, E3 ubiquitin ligase, transcript variant 2 (from RefSeq NM_008052.4) DTX1_MOUSE ENSMUST00000031607.1 ENSMUST00000031607.2 ENSMUST00000031607.3 ENSMUST00000031607.4 ENSMUST00000031607.5 ENSMUST00000031607.6 NM_008052 Q3TER5 Q61010 Q8C2H2 Q9ER09 uc008zhu.1 uc008zhu.2 uc008zhu.3 Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1 via its N-terminal region and EIF3F, the interaction is required for NOTCH1 deubiquitination. Interacts with EP300. Forms a heterodimer with BBAP; the heterodimerization leading to an increase of in vitro ubiquitin ligase activity. Interacts with ITCH. Cytoplasm Nucleus Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q61010-1; Sequence=Displayed; Name=2; IsoId=Q61010-2; Sequence=VSP_008348; Name=3; IsoId=Q61010-3; Sequence=VSP_008349; Predominantly expressed in the brain and testis. Weakly expressed in the thymus, spleen and ovary. Predominantly expressed in regions containing post-mitotic differentiating neurons. In the CNS, it is expressed in the developing neural tube starting from 10.5 dpc in the spinal cord and around 11.5 dpc in the telencephalon. Expressed ubiquitously throughout the spinal cord and telencephalon during neurogenesis. Expressed throughout the developing retina from 12.5 to 15.5 dpc. Expressed in the developing thymus. Not expressed in the somite or presomite during somitogenesis. Expressed slightly later that Dtx2. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH. [Isoform 2]: Splicing acceptor site not canonical. Belongs to the Deltex family. Notch binding protein binding nucleus nucleoplasm cytoplasm cytosol Notch signaling pathway zinc ion binding regulation of Notch signaling pathway glial cell differentiation protein ubiquitination nuclear body transferase activity SH3 domain binding ubiquitin protein ligase binding negative regulation of T cell differentiation negative regulation of neuron differentiation metal ion binding cellular response to leukemia inhibitory factor uc008zhu.1 uc008zhu.2 uc008zhu.3 
ENSMUST00000031613.11 Aimp2 ENSMUST00000031613.11 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2, transcript variant 1 (from RefSeq NM_001172146.1) AIMP2_MOUSE E9QP67 ENSMUST00000031613.1 ENSMUST00000031613.10 ENSMUST00000031613.2 ENSMUST00000031613.3 ENSMUST00000031613.4 ENSMUST00000031613.5 ENSMUST00000031613.6 ENSMUST00000031613.7 ENSMUST00000031613.8 ENSMUST00000031613.9 Jtv1 NM_001172146 Q8R010 Q8R2Y6 uc009akw.1 uc009akw.2 uc009akw.3 Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:12060739). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation (PubMed:12819782). Blocks MDM2-mediated ubiquitination and degradation of p53/TP53 (PubMed:18695251). Functions as a proapoptotic factor (PubMed:16135753). Part of the multisynthetase complex (MSC), a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:12060739). Interacts (via N-terminus) with KARS1. Interacts with EPRS1. Forms a linear complex that contains MARS1, EEF1E1, EPRS1 and AIMP2 that is at the core of the multisubunit complex. Binds FUBP1 (via C-terminus) (By similarity). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with PRKN/parkin (via first RING-type domain). Interacts with TARS3. Cytoplasm, cytosol Nucleus Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. Phosphorylated on serine residues in response to UV irradiation. Ubiquitinated by PRKN, leading to its degradation by the proteasome. Reduced levels of component enzymes and associated factors of the aminoacyl-tRNA synthase complex, lack of complex formation and lethality within two days of birth. Neonates display severe hyperplasia in a number of organs including lung, intestine and liver, lung failure, and disturbed thymocyte proliferation and differentiation. Embryonic fibroblasts deficient in Aimp2 are resistant to apoptosis following UV irradiation. protein binding nucleus cytoplasm cytosol translation apoptotic process multicellular organism development negative regulation of cell proliferation aminoacyl-tRNA synthetase multienzyme complex cell differentiation positive regulation of protein ubiquitination binding, bridging Type II pneumocyte differentiation macromolecular complex assembly positive regulation of neuron death positive regulation of aminoacyl-tRNA ligase activity uc009akw.1 uc009akw.2 uc009akw.3 
ENSMUST00000031617.13 Rpl6 ENSMUST00000031617.13 ribosomal protein L6, transcript variant 1 (from RefSeq NM_011290.5) ENSMUST00000031617.1 ENSMUST00000031617.10 ENSMUST00000031617.11 ENSMUST00000031617.12 ENSMUST00000031617.2 ENSMUST00000031617.3 ENSMUST00000031617.4 ENSMUST00000031617.5 ENSMUST00000031617.6 ENSMUST00000031617.7 ENSMUST00000031617.8 ENSMUST00000031617.9 NM_011290 Q3UCH0 Q3UCH0_MOUSE Rpl6 uc008ziq.1 uc008ziq.2 uc008ziq.3 uc008ziq.4 uc008ziq.5 Cytoplasm, cytosol Endoplasmic reticulum Rough endoplasmic reticulum Belongs to the eukaryotic ribosomal protein eL6 family. cytoplasmic translation structural constituent of ribosome nucleus ribosome translation cytosolic large ribosomal subunit cytoplasmic ribonucleoprotein granule polysomal ribosome uc008ziq.1 uc008ziq.2 uc008ziq.3 uc008ziq.4 uc008ziq.5 
ENSMUST00000031621.11 Ccz1 ENSMUST00000031621.11 CCZ1 vacuolar protein trafficking and biogenesis associated, transcript variant 1 (from RefSeq NM_177682.4) CCZ1_MOUSE ENSMUST00000031621.1 ENSMUST00000031621.10 ENSMUST00000031621.2 ENSMUST00000031621.3 ENSMUST00000031621.4 ENSMUST00000031621.5 ENSMUST00000031621.6 ENSMUST00000031621.7 ENSMUST00000031621.8 ENSMUST00000031621.9 NM_177682 Q3U891 Q8C1Y8 uc009ale.1 uc009ale.2 Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Interacts with MON1A. Found in a complex with RMC1, CCZ1 MON1A and MON1B. Lysosome membrane Belongs to the CCZ1 family. guanyl-nucleotide exchange factor activity lysosome lysosomal membrane cytosol membrane vesicle-mediated transport aggresome Mon1-Ccz1 complex intracellular membrane-bounded organelle uc009ale.1 uc009ale.2 
ENSMUST00000031622.13 Ocm ENSMUST00000031622.13 oncomodulin (from RefSeq NM_033039.3) ENSMUST00000031622.1 ENSMUST00000031622.10 ENSMUST00000031622.11 ENSMUST00000031622.12 ENSMUST00000031622.2 ENSMUST00000031622.3 ENSMUST00000031622.4 ENSMUST00000031622.5 ENSMUST00000031622.6 ENSMUST00000031622.7 ENSMUST00000031622.8 ENSMUST00000031622.9 NM_033039 ONCO_MOUSE P51879 Q62004 uc291bpc.1 uc291bpc.2 Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions. Found in tumor tissues and not detected in normal tissues. Belongs to the parvalbumin family. calcium ion binding extracellular space nucleus cytoplasm response to wounding vesicle stereocilium cuticular plate macromolecular complex protein homodimerization activity metal ion binding protein heterodimerization activity positive regulation of axon extension involved in regeneration protein homotetramerization protein homotrimerization cochlea development supramolecular fiber positive regulation of retinal ganglion cell axon guidance positive regulation of optical nerve axon regeneration uc291bpc.1 uc291bpc.2 
ENSMUST00000031624.5 1700018F24Rik ENSMUST00000031624.5 RIKEN cDNA 1700018F24 gene (from RefSeq NM_027069.3) 1700018F24Rik B2RW27 B2RW27_MOUSE ENSMUST00000031624.1 ENSMUST00000031624.2 ENSMUST00000031624.3 ENSMUST00000031624.4 NM_027069 uc009alz.1 uc009alz.2 uc009alz.3 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc009alz.1 uc009alz.2 uc009alz.3 
ENSMUST00000031625.15 Arpc1a ENSMUST00000031625.15 actin related protein 2/3 complex, subunit 1A (from RefSeq NM_019767.2) ARC1A_MOUSE ENSMUST00000031625.1 ENSMUST00000031625.10 ENSMUST00000031625.11 ENSMUST00000031625.12 ENSMUST00000031625.13 ENSMUST00000031625.14 ENSMUST00000031625.2 ENSMUST00000031625.3 ENSMUST00000031625.4 ENSMUST00000031625.5 ENSMUST00000031625.6 ENSMUST00000031625.7 ENSMUST00000031625.8 ENSMUST00000031625.9 NM_019767 Q3UL75 Q9R0Q6 Sid329 uc009ama.1 uc009ama.2 uc009ama.3 Probably functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). Probable component of the Arp2/3 complex in which it may replace ARPC1B. Cytoplasm, cytoskeleton Nucleus Belongs to the WD repeat ARPC1 family. actin binding protein binding nucleus cytoplasm cytoskeleton Arp2/3 protein complex actin cytoskeleton regulation of actin filament polymerization Arp2/3 complex-mediated actin nucleation site of double-strand break muscle cell projection membrane actin filament binding uc009ama.1 uc009ama.2 uc009ama.3 
ENSMUST00000031627.9 Pdap1 ENSMUST00000031627.9 PDGFA associated protein 1, transcript variant 2 (from RefSeq NR_156700.1) A0JLS1 ENSMUST00000031627.1 ENSMUST00000031627.2 ENSMUST00000031627.3 ENSMUST00000031627.4 ENSMUST00000031627.5 ENSMUST00000031627.6 ENSMUST00000031627.7 ENSMUST00000031627.8 HAP28_MOUSE NR_156700 Q3KQJ5 Q3UHX2 uc009ame.1 uc009ame.2 uc009ame.3 Phosphorylated by several kinases in vitro. In vivo, can be phosphorylated by CK2. Belongs to the PDAP1 family. extracellular space cytosol plasma membrane platelet-derived growth factor receptor signaling pathway platelet-derived growth factor binding uc009ame.1 uc009ame.2 uc009ame.3 
ENSMUST00000031628.10 Ptcd1 ENSMUST00000031628.10 pentatricopeptide repeat domain 1 (from RefSeq NM_133735.2) ENSMUST00000031628.1 ENSMUST00000031628.2 ENSMUST00000031628.3 ENSMUST00000031628.4 ENSMUST00000031628.5 ENSMUST00000031628.6 ENSMUST00000031628.7 ENSMUST00000031628.8 ENSMUST00000031628.9 NM_133735 PTCD1_MOUSE Q3TB29 Q5XK29 Q8C2E4 Q99KB2 uc009amh.1 uc009amh.2 uc009amh.3 uc009amh.4 Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria- encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs. Associates with mitochondrial leucine tRNAs. Interacts with ELAC2. Mitochondrion Mitochondrion matrix Belongs to the PTCD1 family. tRNA binding mitochondrion mitochondrial matrix tRNA processing tRNA 3'-end processing uc009amh.1 uc009amh.2 uc009amh.3 uc009amh.4 
ENSMUST00000031632.9 Zkscan14 ENSMUST00000031632.9 zinc finger with KRAB and SCAN domains 14 (from RefSeq NM_023322.2) B9EIZ4 ENSMUST00000031632.1 ENSMUST00000031632.2 ENSMUST00000031632.3 ENSMUST00000031632.4 ENSMUST00000031632.5 ENSMUST00000031632.6 ENSMUST00000031632.7 ENSMUST00000031632.8 NM_023322 Q3U4Z1 Q9CYV9 Q9CZG8 Q9Z1D9 ZN394_MOUSE Zfp94 Zfp99 Znf394 uc009amm.1 uc009amm.2 uc009amm.3 May be involved in transcriptional regulation. Nucleus Expressed at high level in testis. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAB28368.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009amm.1 uc009amm.2 uc009amm.3 
ENSMUST00000031633.5 Cyp3a16 ENSMUST00000031633.5 cytochrome P450, family 3, subfamily a, polypeptide 16 (from RefSeq NM_007820.2) CP3AG_MOUSE Cyp3a-16 E9QP65 ENSMUST00000031633.1 ENSMUST00000031633.2 ENSMUST00000031633.3 ENSMUST00000031633.4 NM_007820 Q64481 uc009amv.1 uc009amv.2 uc009amv.3 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Fetal- and puberty-specific. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane steroid metabolic process steroid hydroxylase activity retinoic acid 4-hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding organelle membrane demethylase activity intracellular membrane-bounded organelle metal ion binding testosterone 6-beta-hydroxylase activity oxidation-reduction process aromatase activity oxidative demethylation estrogen 16-alpha-hydroxylase activity uc009amv.1 uc009amv.2 uc009amv.3 
ENSMUST00000031640.15 Cdk8 ENSMUST00000031640.15 cyclin dependent kinase 8, transcript variant 1 (from RefSeq NM_153599.4) CDK8_MOUSE ENSMUST00000031640.1 ENSMUST00000031640.10 ENSMUST00000031640.11 ENSMUST00000031640.12 ENSMUST00000031640.13 ENSMUST00000031640.14 ENSMUST00000031640.2 ENSMUST00000031640.3 ENSMUST00000031640.4 ENSMUST00000031640.5 ENSMUST00000031640.6 ENSMUST00000031640.7 ENSMUST00000031640.8 ENSMUST00000031640.9 NM_153599 Q8R3L8 uc009and.1 uc009and.2 uc009and.3 Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho- [DNA-directed RNA polymerase]; Xref=Rhea:RHEA:10216, Rhea:RHEA- COMP:11321, Rhea:RHEA-COMP:11322, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.23; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1 (By similarity). Q8R3L8; A2AGH6: Med12; NbExp=3; IntAct=EBI-5745402, EBI-5744969; Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R3L8-1; Sequence=Displayed; Name=2; IsoId=Q8R3L8-2; Sequence=VSP_023673, VSP_023674; Name=3; IsoId=Q8R3L8-3; Sequence=VSP_023675; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. ubiquitin ligase complex nucleotide binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm nucleolus protein phosphorylation RNA polymerase II carboxy-terminal domain kinase activity kinase activity phosphorylation protein ubiquitination mediator complex transferase activity macromolecular complex regulation of cell cycle negative regulation of triglyceride metabolic process ubiquitin protein ligase activity uc009and.1 uc009and.2 uc009and.3 
ENSMUST00000031646.8 Rasl11a ENSMUST00000031646.8 RAS-like, family 11, member A (from RefSeq NM_026864.1) ENSMUST00000031646.1 ENSMUST00000031646.2 ENSMUST00000031646.3 ENSMUST00000031646.4 ENSMUST00000031646.5 ENSMUST00000031646.6 ENSMUST00000031646.7 NM_026864 Q148R6 Q6IMB1 RSLBA_MOUSE Rasl11a uc009anm.1 uc009anm.2 Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Interacts with UBF/UBTF. Nucleus, nucleolus Note=Associates with rDNA transcription unit throughout the cell cycle. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q6IMB1-1; Sequence=Displayed; Name=2 ; IsoId=Q6IMB1-2; Sequence=VSP_052584; Belongs to the small GTPase superfamily. Ras family. Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which serves to target Ras proteins to membrane compartments. nucleotide binding GTPase activity protein binding GTP binding nucleus nucleolus signal transduction membrane positive regulation of transcription from RNA polymerase I promoter uc009anm.1 uc009anm.2 
ENSMUST00000031650.4 Cdx2 ENSMUST00000031650.4 caudal type homeobox 2 (from RefSeq NM_007673.3) Cdx2 ENSMUST00000031650.1 ENSMUST00000031650.2 ENSMUST00000031650.3 NM_007673 Q543L9 Q543L9_MOUSE uc009anz.1 uc009anz.2 uc009anz.3 Nucleus Belongs to the Caudal homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development positive regulation of cell proliferation methyl-CpG binding sequence-specific DNA binding positive regulation of transcription, DNA-templated uc009anz.1 uc009anz.2 uc009anz.3 
ENSMUST00000031653.12 Flt1 ENSMUST00000031653.12 FMS-like tyrosine kinase 1, transcript variant 1 (from RefSeq NM_010228.4) A0A0R4J0A4 A0A0R4J0A4_MOUSE ENSMUST00000031653.1 ENSMUST00000031653.10 ENSMUST00000031653.11 ENSMUST00000031653.2 ENSMUST00000031653.3 ENSMUST00000031653.4 ENSMUST00000031653.5 ENSMUST00000031653.6 ENSMUST00000031653.7 ENSMUST00000031653.8 ENSMUST00000031653.9 Flt1 NM_010228 uc009aoh.1 uc009aoh.2 uc009aoh.3 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Cell membrane ; Single-pass type I membrane protein Membrane ingle-pass type I membrane protein Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. nucleotide binding monocyte chemotaxis protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity ATP binding plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of phospholipase C activity positive regulation of phosphatidylinositol 3-kinase signaling actin cytoskeleton membrane integral component of membrane kinase activity phosphorylation cell migration transferase activity peptidyl-tyrosine phosphorylation growth factor binding positive regulation of cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-1 signaling pathway VEGF-A-activated receptor activity VEGF-B-activated receptor activity placental growth factor-activated receptor activity vascular endothelial growth factor signaling pathway receptor complex positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway negative regulation of vascular endothelial cell proliferation uc009aoh.1 uc009aoh.2 uc009aoh.3 
ENSMUST00000031654.10 Pomp ENSMUST00000031654.10 proteasome maturation protein (from RefSeq NM_025624.3) ENSMUST00000031654.1 ENSMUST00000031654.2 ENSMUST00000031654.3 ENSMUST00000031654.4 ENSMUST00000031654.5 ENSMUST00000031654.6 ENSMUST00000031654.7 ENSMUST00000031654.8 ENSMUST00000031654.9 NM_025624 POMP_MOUSE Q9CQT5 Q9CXV8 Q9CZL7 uc009aok.1 uc009aok.2 uc009aok.3 Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation (By similarity). Mediates the association of 20S preproteasome with the endoplasmic reticulum (By similarity). Constituent of preproteasomes, but not of mature 20S proteasomes. Within the preproteasome, may directly interact with PSMB1/beta6, PSMB4/beta7, PSMB5/beta5, PSMB6/beta1 and PSMB9/beta1i. Interaction with PSMB8/beta5i is controversial. Forms tetramers (By similarity). Cytoplasm, cytosol Nucleus Microsome membrane Widely expressed. By interferon gamma. Belongs to the POMP/UMP1 family. nucleus cytoplasm endoplasmic reticulum cytosol membrane nuclear speck organelle membrane intracellular membrane-bounded organelle proteasome assembly uc009aok.1 uc009aok.2 uc009aok.3 
ENSMUST00000031663.10 C8b ENSMUST00000031663.10 complement component 8, beta polypeptide, transcript variant 1 (from RefSeq NM_133882.2) CO8B_MOUSE ENSMUST00000031663.1 ENSMUST00000031663.2 ENSMUST00000031663.3 ENSMUST00000031663.4 ENSMUST00000031663.5 ENSMUST00000031663.6 ENSMUST00000031663.7 ENSMUST00000031663.8 ENSMUST00000031663.9 NM_133882 Q4VAH1 Q8BH35 Q8CHJ5 Q8CHJ6 Q8VC14 uc008txy.1 uc008txy.2 This gene encodes the beta subunit of complement component C8 that participates in the assembly of the complement membrane attack complex. The encoded preproprotein undergoes proteolytic processing to generate the beta subunit, which associates with the alpha and gamma subunits to form a trimeric complement component, C8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. This gene is located adjacent to the gene encoding the alpha subunit. [provided by RefSeq, Oct 2015]. Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b sequentially binds C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity). Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BH35-1; Sequence=Displayed; Name=2; IsoId=Q8BH35-2; Sequence=VSP_016666; Belongs to the complement C6/C7/C8/C9 family. immune system process extracellular region membrane attack complex extracellular space immune response complement activation complement activation, alternative pathway complement activation, classical pathway cytolysis macromolecular complex binding innate immune response uc008txy.1 uc008txy.2 
ENSMUST00000031668.10 Col1a2 ENSMUST00000031668.10 collagen, type I, alpha 2 (from RefSeq NM_007743.3) Col1a2 ENSMUST00000031668.1 ENSMUST00000031668.2 ENSMUST00000031668.3 ENSMUST00000031668.4 ENSMUST00000031668.5 ENSMUST00000031668.6 ENSMUST00000031668.7 ENSMUST00000031668.8 ENSMUST00000031668.9 NM_007743 Q3TX57 Q3TX57_MOUSE uc009avm.1 uc009avm.2 uc009avm.3 uc009avm.4 This gene encodes the alpha-2 subunit of the fibril-forming type I collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-1 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice harboring certain mutations in the encoded gene exhibit symptoms of moderate to severe forms of osteogenesis imperfecta. [provided by RefSeq, Dec 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK132496.1, AK159578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Type I collagen is a member of group I collagen (fibrillar forming collagen). Trimers of one alpha 2(I) and two alpha 1(I) chains. skeletal system development blood vessel development protease binding extracellular matrix structural constituent collagen trimer collagen type I trimer extracellular space endoplasmic reticulum transforming growth factor beta receptor signaling pathway Rho protein signal transduction regulation of blood pressure collagen fibril organization protein binding, bridging identical protein binding skin morphogenesis platelet-derived growth factor binding uc009avm.1 uc009avm.2 uc009avm.3 uc009avm.4 
ENSMUST00000031670.10 Gng11 ENSMUST00000031670.10 guanine nucleotide binding protein (G protein), gamma 11 (from RefSeq NM_025331.2) ENSMUST00000031670.1 ENSMUST00000031670.2 ENSMUST00000031670.3 ENSMUST00000031670.4 ENSMUST00000031670.5 ENSMUST00000031670.6 ENSMUST00000031670.7 ENSMUST00000031670.8 ENSMUST00000031670.9 GBG11_MOUSE Gngt11 NM_025331 P50152 P61953 Q4QRN2 uc009avj.1 uc009avj.2 uc009avj.3 uc009avj.4 uc009avj.5 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2 (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Belongs to the G protein gamma family. GTPase activity heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane G-protein beta/gamma-subunit complex G-protein beta-subunit binding uc009avj.1 uc009avj.2 uc009avj.3 uc009avj.4 uc009avj.5 
ENSMUST00000031673.7 Gngt1 ENSMUST00000031673.7 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 (from RefSeq NM_010314.3) ENSMUST00000031673.1 ENSMUST00000031673.2 ENSMUST00000031673.3 ENSMUST00000031673.4 ENSMUST00000031673.5 ENSMUST00000031673.6 GBG1_MOUSE Gng1 NM_010314 Q61012 Q9CR01 uc009avi.1 uc009avi.2 uc009avi.3 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units, alpha, beta and gamma. Cell membrane ; Lipid-anchor ; Cytoplasmic side Retinal rod outer segment. Mass=8314.5; Mass_error=0.1; Method=Electrospray; Note=Includes farnesylation and methylation.; Evidence=; Belongs to the G protein gamma family. photoreceptor outer segment photoreceptor inner segment GTPase activity heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway phototransduction protein localization cardiac muscle cell apoptotic process membrane G-protein beta/gamma-subunit complex G-protein beta-subunit binding eye photoreceptor cell development cellular response to hypoxia uc009avi.1 uc009avi.2 uc009avi.3 
ENSMUST00000031674.11 Tfpi2 ENSMUST00000031674.11 tissue factor pathway inhibitor 2, transcript variant 1 (from RefSeq NM_009364.4) ENSMUST00000031674.1 ENSMUST00000031674.10 ENSMUST00000031674.2 ENSMUST00000031674.3 ENSMUST00000031674.4 ENSMUST00000031674.5 ENSMUST00000031674.6 ENSMUST00000031674.7 ENSMUST00000031674.8 ENSMUST00000031674.9 NM_009364 Q3V1S9 Q3V1S9_MOUSE Tfpi2 uc009avh.1 uc009avh.2 uc009avh.3 Secreted serine-type endopeptidase inhibitor activity extracellular region blood coagulation hemostasis negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity cellular response to fluid shear stress uc009avh.1 uc009avh.2 uc009avh.3 
ENSMUST00000031678.10 Tspan12 ENSMUST00000031678.10 tetraspanin 12, transcript variant 1 (from RefSeq NM_173007.4) ENSMUST00000031678.1 ENSMUST00000031678.2 ENSMUST00000031678.3 ENSMUST00000031678.4 ENSMUST00000031678.5 ENSMUST00000031678.6 ENSMUST00000031678.7 ENSMUST00000031678.8 ENSMUST00000031678.9 NM_173007 Q6P1C3 Q8BKT6 Q8BZU1 TSN12_MOUSE Tm4sf12 uc009bar.1 uc009bar.2 Regulator of cell surface receptor signal transduction. Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1- MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity). Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Interacts (when palmitoylated) with ADAM10. Interacts with MMP14/MT1-MMP (By similarity). Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BKT6-1; Sequence=Displayed; Name=2; IsoId=Q8BKT6-2; Sequence=VSP_038526; Expressed in the neonatal retinal vasculature but not other retinal tissues. Also detected in the neonatal meningeal vasculature and in nonvascular cell types, such as the smooth muscle cells in the neonatal intestine. Palmitoylated; required for interaction with ADAM10. Mice are viable and fertile but display defects in retinal vascularization. In retinas between P5 and P12, the centrifugal outgrowth of the nerve fiber layer (NFL) vasculature is moderately delayed in retinas. At P11, vertical sprouts and plexiform layer (OPL) capillaries appear in wild-type mice, whereas both are completely absent in mutant mice. In adult mutant mice, the plexiform layer (OPL) remains avascular, confirming that the defect is not transient. The thickness of the outer nuclear layer in retinas is consistently reduced in adult mutant but not neonatal mice, indicating that neural cells are secondarily affected by the vascular defects. Belongs to the tetraspanin (TM4SF) family. angiogenesis plasma membrane integral component of plasma membrane cell surface receptor signaling pathway retina layer formation membrane integral component of membrane Wnt signaling pathway regulation of angiogenesis Wnt-activated receptor activity uc009bar.1 uc009bar.2 
ENSMUST00000031680.10 Ing3 ENSMUST00000031680.10 inhibitor of growth family, member 3, transcript variant 1 (from RefSeq NM_023626.4) ENSMUST00000031680.1 ENSMUST00000031680.2 ENSMUST00000031680.3 ENSMUST00000031680.4 ENSMUST00000031680.5 ENSMUST00000031680.6 ENSMUST00000031680.7 ENSMUST00000031680.8 ENSMUST00000031680.9 ING3_MOUSE NM_023626 Q8VEK6 Q99JS6 Q9ERB2 uc009bat.1 uc009bat.2 uc009bat.3 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Interacts with H3K4me3 and to a lesser extent with H3K4me2 (By similarity). Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. Component of a SWR1-like complex (By similarity). Nucleus The PHD-type zinc finger mediates the binding to H3K4me3. Belongs to the ING family. Sequence=AAG23286.1; Type=Erroneous initiation; Evidence=; Sequence=AAH18342.1; Type=Erroneous initiation; Evidence=; Sequence=BAC38021.1; Type=Erroneous initiation; Evidence=; Swr1 complex histone acetyltransferase activity nucleus chromatin organization Piccolo NuA4 histone acetyltransferase complex methylated histone binding NuA4 histone acetyltransferase complex regulation of growth positive regulation of apoptotic process histone H4 acetylation histone H2A acetylation metal ion binding uc009bat.1 uc009bat.2 uc009bat.3 
ENSMUST00000031681.10 Wnt16 ENSMUST00000031681.10 wingless-type MMTV integration site family, member 16 (from RefSeq NM_053116.4) ENSMUST00000031681.1 ENSMUST00000031681.2 ENSMUST00000031681.3 ENSMUST00000031681.4 ENSMUST00000031681.5 ENSMUST00000031681.6 ENSMUST00000031681.7 ENSMUST00000031681.8 ENSMUST00000031681.9 NM_053116 Q14BF7 Q9QYS1 WNT16_MOUSE uc009bax.1 uc009bax.2 uc009bax.3 uc009bax.4 Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Secreted, extracellular space, extracellular matrix. Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. Belongs to the Wnt family. receptor binding frizzled binding extracellular region extracellular space cytoplasm multicellular organism development positive regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling Wnt signaling pathway neuron differentiation keratinocyte differentiation keratinocyte proliferation cell fate commitment positive regulation of JNK cascade bone remodeling cardiac epithelial to mesenchymal transition negative regulation of cell death replicative senescence oxidative stress-induced premature senescence uc009bax.1 uc009bax.2 uc009bax.3 uc009bax.4 
ENSMUST00000031690.6 Hyal6 ENSMUST00000031690.6 hyaluronoglucosaminidase 6 (from RefSeq NM_028920.2) ENSMUST00000031690.1 ENSMUST00000031690.2 ENSMUST00000031690.3 ENSMUST00000031690.4 ENSMUST00000031690.5 Hyal-ps1 Hyal6 NM_028920 Q9D4E9 Q9D4E9_MOUSE uc009bbw.1 uc009bbw.2 Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D- glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35; Evidence= Monomer. Belongs to the glycosyl hydrolase 56 family. molecular_function catalytic activity hyalurononglucosaminidase activity cellular_component carbohydrate metabolic process biological_process metabolic process membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds uc009bbw.1 uc009bbw.2 
ENSMUST00000031691.3 Hyal4 ENSMUST00000031691.3 hyaluronoglucosaminidase 4 (from RefSeq NM_029848.1) ENSMUST00000031691.1 ENSMUST00000031691.2 HYAL4_MOUSE NM_029848 Q05A56 Q9D660 uc009bbx.1 uc009bbx.2 uc009bbx.3 Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide (By similarity). Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D- glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35; Membrane ; Multi-pass membrane protein Belongs to the glycosyl hydrolase 56 family. catalytic activity hyalurononglucosaminidase activity carbohydrate metabolic process metabolic process cell surface membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds chondroitin sulfate catabolic process uc009bbx.1 uc009bbx.2 uc009bbx.3 
ENSMUST00000031692.12 Bcl7b ENSMUST00000031692.12 B cell CLL/lymphoma 7B (from RefSeq NM_009745.2) BCL7B_MOUSE ENSMUST00000031692.1 ENSMUST00000031692.10 ENSMUST00000031692.11 ENSMUST00000031692.2 ENSMUST00000031692.3 ENSMUST00000031692.4 ENSMUST00000031692.5 ENSMUST00000031692.6 ENSMUST00000031692.7 ENSMUST00000031692.8 ENSMUST00000031692.9 NM_009745 O89022 Q3TV31 Q3U2W0 Q921K9 uc012een.1 uc012een.2 uc012een.3 Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (By similarity). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (By similarity). May play a role in lung tumor development or progression. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q921K9-1; Sequence=Displayed; Name=2; IsoId=Q921K9-2; Sequence=VSP_019280, VSP_019281; Belongs to the BCL7 family. Sequence=CAA09501.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component apoptotic process biological_process Wnt signaling pathway cell differentiation uc012een.1 uc012een.2 uc012een.3 
ENSMUST00000031694.8 Lmod2 ENSMUST00000031694.8 leiomodin 2 (cardiac) (from RefSeq NM_053098.2) ENSMUST00000031694.1 ENSMUST00000031694.2 ENSMUST00000031694.3 ENSMUST00000031694.4 ENSMUST00000031694.5 ENSMUST00000031694.6 ENSMUST00000031694.7 LMOD2_MOUSE NM_053098 Q3UHZ5 Q99PM7 uc009bbu.1 uc009bbu.2 uc009bbu.3 Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length (PubMed:26487682). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:26487682, PubMed:27274810). Can bind at least three actin monomers and thereby provides a nucleus for actin filament formation. Interacts (via N-terminus) with tropomyosin alpha (TPM1) (via N-terminus). May also interact with TPM2 (via N-terminus) (PubMed:17572376). Cytoplasm, myofibril, sarcomere Cytoplasm, myofibril Cytoplasm, myofibril, sarcomere, M line Cytoplasm, cytoskeleton Note=Colocalizes with actin filaments in sarcomeres. Detected close to the M line. Detected in neonate heart (at protein level) (PubMed:26487682). Detected in embryonic heart and in pharyngeal arches (PubMed:26487682). Detected in adult heart (PubMed:27274810). Mutant mice are born at the expected Mendelian rate. All die between 15 to 33 days after birth due to early-onset dilated cardiomyopathy. Cardiac muscle thin filaments are shorter than in wild-type, both in embryonic heart and in pups 6 or 15 days after birth. Hearts appear grossly normal at birth, but after 15 days, they display enlarged left ventricles with thin ventricle walls and resuced systolic performance. In contrast, there are no differences in thin filament length in skeletal muscle (PubMed:26487682). Insertion of a transposon in the first, non-coding exon decreases Lmod2 expression by 90% in females and by over 95% in males and gives rise to a phenotype that is closely similar to that of complete gene disruption, except that mutant mice die between three and nine weeks after birth (PubMed:27274810). Belongs to the tropomodulin family. Sequence=AAK00789.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; actin binding actin monomer binding tropomyosin binding cytoplasm cytoskeleton striated muscle thin filament actin filament muscle contraction myofibril sarcomere actin filament polymerization myofibril assembly positive regulation of actin filament polymerization M band actin nucleation sarcomere organization pointed-end actin filament capping cardiac myofibril uc009bbu.1 uc009bbu.2 uc009bbu.3 
ENSMUST00000031695.15 Wasl ENSMUST00000031695.15 WASP like actin nucleation promoting factor, transcript variant 1 (from RefSeq NM_028459.2) ENSMUST00000031695.1 ENSMUST00000031695.10 ENSMUST00000031695.11 ENSMUST00000031695.12 ENSMUST00000031695.13 ENSMUST00000031695.14 ENSMUST00000031695.2 ENSMUST00000031695.3 ENSMUST00000031695.4 ENSMUST00000031695.5 ENSMUST00000031695.6 ENSMUST00000031695.7 ENSMUST00000031695.8 ENSMUST00000031695.9 NM_028459 Q91YD9 WASL_MOUSE uc009bbv.1 uc009bbv.2 uc009bbv.3 uc009bbv.4 Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (PubMed:12871950). Plays a role in dendrite spine morphogenesis (PubMed:25851601). Binds actin and the Arp2/3 complex. Interacts with CDC42 (By similarity). Interacts with FCHSD1 (PubMed:29887380). Interacts with FCHSD2 (PubMed:23437151, PubMed:29887380). Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP (PubMed:14506234). Interacts with SNX9 (By similarity). Interacts with the WW domains of PRPF40A/FBP11 (PubMed:14697212). Interacts with PTK2/FAK1 (PubMed:14676198). Interacts with PACSIN1, PACSIN2 and PACSIN3 (PubMed:11082044). Interacts with NOSTRIN. Binds to TNK2. Interacts with SNX33. Interacts with NONO (via second RRM domain); the interaction is direct. Component of a multiprotein complex with NONO and SFPQ; associates with the complex via direct interaction with NONO (By similarity). Q91YD9; Q60598: Cttn; NbExp=4; IntAct=EBI-642417, EBI-397955; Q91YD9; P09055: Itgb1; NbExp=2; IntAct=EBI-642417, EBI-644224; Q91YD9; P05622: Pdgfrb; NbExp=2; IntAct=EBI-642417, EBI-1554855; Q91YD9; P68135: ACTA1; Xeno; NbExp=5; IntAct=EBI-642417, EBI-367540; Cytoplasm, cytoskeleton Nucleus toplasm te=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (PubMed:12871950, PubMed:14676198). Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm (PubMed:12871950). Phosphorylation at Ser-239, Tyr-253, Ser-480 and Ser-481 enhances actin polymerization activity. Golgi membrane actin cortical patch assembly actin binding protein binding nucleus cytoplasm cytosol cytoskeleton actin filament endocytosis membrane budding actin filament organization cell cycle cytoskeletal protein binding response to bacterium membrane invagination vesicle organization lamellipodium actin cytoskeleton organization actin filament polymerization actin filament-based movement vesicle transport along actin filament actin cap actin cortical patch cell leading edge cytoplasmic vesicle regulation of protein localization cellular protein complex localization identical protein binding actin nucleation positive regulation of transcription from RNA polymerase II promoter actin filament binding cell division positive regulation of filopodium assembly spindle localization actin cortical patch localization dendritic spine morphogenesis plasma membrane tubulation postsynapse postsynaptic actin cytoskeleton organization glutamatergic synapse negative regulation of membrane tubulation positive regulation of clathrin-dependent endocytosis negative regulation of lymphocyte migration positive regulation of Arp2/3 complex-mediated actin nucleation cell projection assembly uc009bbv.1 uc009bbv.2 uc009bbv.3 uc009bbv.4 
ENSMUST00000031696.10 Asb15 ENSMUST00000031696.10 ankyrin repeat and SOCS box-containing 15 (from RefSeq NM_080847.3) ASB15_MOUSE ENSMUST00000031696.1 ENSMUST00000031696.2 ENSMUST00000031696.3 ENSMUST00000031696.4 ENSMUST00000031696.5 ENSMUST00000031696.6 ENSMUST00000031696.7 ENSMUST00000031696.8 ENSMUST00000031696.9 NM_080847 Q8CDP8 Q8VHS6 uc009bbt.1 uc009bbt.2 uc009bbt.3 uc009bbt.4 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Q8VHS6; Q80W03: Tox3; NbExp=2; IntAct=EBI-26675998, EBI-26675915; The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Belongs to the ankyrin SOCS box (ASB) family. biological_process protein ubiquitination intracellular signal transduction uc009bbt.1 uc009bbt.2 uc009bbt.3 uc009bbt.4 
ENSMUST00000031697.9 Cul1 ENSMUST00000031697.9 cullin 1, transcript variant 1 (from RefSeq NM_012042.5) CUL1_MOUSE ENSMUST00000031697.1 ENSMUST00000031697.2 ENSMUST00000031697.3 ENSMUST00000031697.4 ENSMUST00000031697.5 ENSMUST00000031697.6 ENSMUST00000031697.7 ENSMUST00000031697.8 NM_012042 Q9WTX6 Q9WUI7 uc009bta.1 uc009bta.2 uc009bta.3 Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1- RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Protein modification; protein ubiquitination. Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin- protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F- box domain-containing protein as substrate-specific subunit (PubMed:10097128, PubMed:12140560, PubMed:16880526, PubMed:23452855, PubMed:23452856). Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXW2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44 (By similarity). Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC (PubMed:10097128, PubMed:11735228). This complex binds phosphorylated NFKBIA (PubMed:10097128). Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF (By similarity). Interacts with CCNF (By similarity). Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7. Interacts with CHEK2; mediates CHEK2 ubiquitination and regulates its function. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction mediates the exchange of the F-box substrate-specific subunit. Can self-associate (By similarity). Interacts with FBXW8 (PubMed:16880526). Interacts with RNF7 (By similarity). Interacts with CUL7; the interaction seems to be mediated by FBXW8 (PubMed:16880526). Interacts with TRIM21 (By similarity). Interacts with COPS2 (PubMed:11967155). Interacts with DCUN1D1 and UBE2M. Interacts with DCUN1D3. Interacts with DCUN1D4 (By similarity). Identified in a complex with RBX1 and GLMN (By similarity). Interacts with CEP68 as part of the SCF(FBXW11) complex; the interaction is probably mediated by FBXW11 and the complex also contains CDK5RAP2 and PCNT. Interacts (when neddylated) with ARIH1; leading to activate the E3 ligase activity of ARIH1. Interacts with COPS9. Interacts with UBXN1 (By similarity). Interacts with KAT7, probably as part of an SCF complex; the interaction mediates KAT7 ubiquitination (PubMed:23319590). Interacts with NOTCH2 (By similarity). Part of a complex that contains DCUN1D5, CUL1 and RBX1; this interaction is bridged by CUL1 (By similarity). Interacts (unneddylated form) with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5; these interactions promote the cullin neddylation (By similarity). (Microbial infection) Interacts with murine cytomegalovirus M48. Q9WTX6; O94888: UBXN7; Xeno; NbExp=3; IntAct=EBI-1551052, EBI-1993627; Q9WTX6; P55072: VCP; Xeno; NbExp=2; IntAct=EBI-1551052, EBI-355164; Embryo fibroblasts and embryo preadipocytes. Neddylated; which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the COP9 signalosome (CSN) complex. (Microbial infection) Deneddylated by murine cytomegalovirus M48 leading to a S-phase-like environment that is required for efficient replication of the viral genome. Belongs to the cullin family. protein binding nucleoplasm ubiquitin-dependent protein catabolic process protein monoubiquitination apoptotic process cell proliferation animal organ morphogenesis viral process protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process cullin-RING ubiquitin ligase complex ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process Parkin-FBXW7-Cul1 ubiquitin ligase complex ubiquitin protein ligase activity uc009bta.1 uc009bta.2 uc009bta.3 
ENSMUST00000031707.14 Aass ENSMUST00000031707.14 aminoadipate-semialdehyde synthase (from RefSeq NM_013930.4) AASS_MOUSE Aass ENSMUST00000031707.1 ENSMUST00000031707.10 ENSMUST00000031707.11 ENSMUST00000031707.12 ENSMUST00000031707.13 ENSMUST00000031707.2 ENSMUST00000031707.3 ENSMUST00000031707.4 ENSMUST00000031707.5 ENSMUST00000031707.6 ENSMUST00000031707.7 ENSMUST00000031707.8 ENSMUST00000031707.9 Lorsdh NM_013930 Q99K67 Q9Z1I9 uc009bbc.1 uc009bbc.2 uc009bbc.3 This gene encodes a bifunctional mitochondrial protein that catalyzes the first two steps in the lysine degradation pathway. The N-terminus contains lysine-ketoglutarate reductase activity and converts lysine to saccharopine, whereas the C-terminus contains saccharopine dehydrogenase activity and converts saccharopine to alpha-aminoadipate semialdehyde. Mutations in a human gene encoding a highly similar protein are associated with familial hyperlysinemia. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AK149400.1, AK044323.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Bifunctional enzyme that catalyzes the first two steps in lysine degradation. Reaction=H2O + L-saccharopine + NADP(+) = 2-oxoglutarate + H(+) + L- lysine + NADPH; Xref=Rhea:RHEA:19373, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16810, ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57951, ChEBI:CHEBI:58349; EC=1.5.1.8; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:19375; Evidence=; Reaction=H2O + L-saccharopine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH; Xref=Rhea:RHEA:24520, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57951, ChEBI:CHEBI:58321; EC=1.5.1.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24521; Evidence=; Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6. Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6. Homotetramer. Mitochondrion Highly expressed in kidney and liver, very low expression is seen in heart, brain, spleen, lung, skeletal muscle and testis. Induced by starvation. The N-terminal and the C-terminal domains contain respectively the lysine ketoglutarate reductase and saccharopine dehydrogenase activity. In the N-terminal section; belongs to the AlaDH/PNT family. In the C-terminal section; belongs to the saccharopine dehydrogenase family. catalytic activity saccharopine dehydrogenase activity cytoplasm mitochondrion generation of precursor metabolites and energy metabolic process oxidoreductase activity L-lysine catabolic process lysine biosynthetic process via aminoadipic acid L-lysine catabolic process to acetyl-CoA via saccharopine intracellular membrane-bounded organelle saccharopine dehydrogenase (NADP+, L-lysine-forming) activity saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity oxidation-reduction process uc009bbc.1 uc009bbc.2 uc009bbc.3 
ENSMUST00000031709.7 Fezf1 ENSMUST00000031709.7 Fez family zinc finger 1 (from RefSeq NM_028462.1) ENSMUST00000031709.1 ENSMUST00000031709.2 ENSMUST00000031709.3 ENSMUST00000031709.4 ENSMUST00000031709.5 ENSMUST00000031709.6 FEZF1_MOUSE Fez NM_028462 Q0VDQ9 Q9CXM3 uc009bbd.1 uc009bbd.2 uc009bbd.3 uc009bbd.4 Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors. Nucleus At 8.0 dpc expressed in prospective forebrain region. At 12.5 dpc, detected in the olfactory epithelium, septum, roof of the telencephalon, amygdala, prethalamus and hypothalamus. Expression was barely detected in the vomeronasal organs at 12.5 dpc. At 15.5 dpc, detected weakly in the olfactory epithelium, amygdala and hypothalamusat 15.5 dpc. Expression was not detected in the olfactory bulb or in the ganglionic eminences, where the interneuron progenitors of the olfactory bulb are generated. Null mutants were born alive but most of them died within one day. The olfactory bulbs were smaller than those of their wild-type at 18.5 dpc and at postnatal day 1. At 14.5 dpc and 18 dpc no abnormalities in the morphology of the telencephalon or diencephalon were detected. There seems to be a redundant role for FEZF1 and FEZF2 in diencephalon development. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding neuron migration nucleic acid binding DNA binding nucleus cytosol multicellular organism development nervous system development axon guidance negative regulation of cell proliferation telencephalon development olfactory bulb development forebrain anterior/posterior pattern specification cell differentiation forebrain development sequence-specific DNA binding cell dedifferentiation transcription regulatory region DNA binding positive regulation of neuron differentiation positive regulation of transcription, DNA-templated metal ion binding regulation of neurogenesis uc009bbd.1 uc009bbd.2 uc009bbd.3 uc009bbd.4 
ENSMUST00000031713.9 Slc13a1 ENSMUST00000031713.9 solute carrier family 13 (sodium/sulfate symporters), member 1 (from RefSeq NM_019481.2) ENSMUST00000031713.1 ENSMUST00000031713.2 ENSMUST00000031713.3 ENSMUST00000031713.4 ENSMUST00000031713.5 ENSMUST00000031713.6 ENSMUST00000031713.7 ENSMUST00000031713.8 NM_019481 Nas1 Nasi1 Q80YB5 Q8R208 Q9D2C3 Q9JHI4 S13A1_MOUSE uc009bbp.1 uc009bbp.2 uc009bbp.3 Sodium:sulfate symporter that mediates sulfate reabsorption in the kidney and small intestine (PubMed:10766815). Can also mediate the transport of selenate and thiosulfate (By similarity). Reaction=3 Na(+)(out) + sulfate(out) = 3 Na(+)(in) + sulfate(in); Xref=Rhea:RHEA:71951, ChEBI:CHEBI:16189, ChEBI:CHEBI:29101; Evidence=; Reaction=3 Na(+)(out) + selenate(out) = 3 Na(+)(in) + selenate(in); Xref=Rhea:RHEA:72079, ChEBI:CHEBI:15075, ChEBI:CHEBI:29101; Evidence=; Reaction=3 Na(+)(out) + thiosulfate(out) = 3 Na(+)(in) + thiosulfate(in); Xref=Rhea:RHEA:72323, ChEBI:CHEBI:29101, ChEBI:CHEBI:33542; Evidence=; Kinetic parameters: KM=0.20 mM for sulfate ; Apical cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9JHI4-1; Sequence=Displayed; Name=2; IsoId=Q9JHI4-2; Sequence=VSP_006121; Name=3; IsoId=Q9JHI4-3; Sequence=VSP_006122; [Isoform 1]: Highly expressed in kidney and ileum, detected at lower levels in duodenum/jejunum and colon, and at very low levels in cecum, testis, adrenal and adipose tissues. [Isoform 2]: Expressed in the kidney. Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. Sequence=AK019876; Type=Frameshift; Evidence=; integral component of plasma membrane ion transport sodium ion transport dicarboxylic acid transport secondary active sulfate transmembrane transporter activity sulfate transport citrate transmembrane transporter activity succinate transmembrane transporter activity symporter activity sodium:sulfate symporter activity citrate transport membrane integral component of membrane sodium:dicarboxylate symporter activity transmembrane transporter activity transmembrane transport succinate transmembrane transport sulfate transmembrane transport uc009bbp.1 uc009bbp.2 uc009bbp.3 
ENSMUST00000031718.14 Pax4 ENSMUST00000031718.14 paired box 4, transcript variant 1 (from RefSeq NM_011038.2) B7ZNC7 ENSMUST00000031718.1 ENSMUST00000031718.10 ENSMUST00000031718.11 ENSMUST00000031718.12 ENSMUST00000031718.13 ENSMUST00000031718.2 ENSMUST00000031718.3 ENSMUST00000031718.4 ENSMUST00000031718.5 ENSMUST00000031718.6 ENSMUST00000031718.7 ENSMUST00000031718.8 ENSMUST00000031718.9 NM_011038 P32115 P97341 PAX4_MOUSE Pax-4 Q9QUR1 Q9R091 uc009bcs.1 uc009bcs.2 uc009bcs.3 uc009bcs.4 Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters. Nucleus. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P32115-1; Sequence=Displayed; Name=2; IsoId=P32115-2; Sequence=VSP_002361; Name=3; IsoId=P32115-3; Sequence=VSP_002362; Expressed in early pancreas. Later restricted to beta cells. Undetectable in adult islets. Belongs to the paired homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated multicellular organism development circadian rhythm animal organ morphogenesis cell differentiation pancreas development endocrine pancreas development response to drug negative regulation of apoptotic process sequence-specific DNA binding regulation of cell differentiation positive regulation of cell differentiation negative regulation of transcription, DNA-templated response to cAMP retina development in camera-type eye uc009bcs.1 uc009bcs.2 uc009bcs.3 uc009bcs.4 
ENSMUST00000031719.7 Fscn3 ENSMUST00000031719.7 fascin actin-bundling protein 3, transcript variant 1 (from RefSeq NM_019569.3) ENSMUST00000031719.1 ENSMUST00000031719.2 ENSMUST00000031719.3 ENSMUST00000031719.4 ENSMUST00000031719.5 ENSMUST00000031719.6 FSCN3_MOUSE NM_019569 Q80YU6 Q9QXW4 uc009bcr.1 uc009bcr.2 uc009bcr.3 Acts as an actin bundling protein. Cytoplasm, cytoskeleton Expressed in testis. Belongs to the fascin family. ruffle actin binding cytoplasm cytoskeleton microvillus actin filament organization establishment or maintenance of cell polarity spermatid development actin cytoskeleton cell migration lamellipodium actin cytoskeleton organization filopodium growth cone protein binding, bridging cell projection membrane actin filament binding actin filament bundle assembly uc009bcr.1 uc009bcr.2 uc009bcr.3 
ENSMUST00000031726.15 Gnb2 ENSMUST00000031726.15 guanine nucleotide binding protein (G protein), beta 2 (from RefSeq NM_010312.5) ENSMUST00000031726.1 ENSMUST00000031726.10 ENSMUST00000031726.11 ENSMUST00000031726.12 ENSMUST00000031726.13 ENSMUST00000031726.14 ENSMUST00000031726.2 ENSMUST00000031726.3 ENSMUST00000031726.4 ENSMUST00000031726.5 ENSMUST00000031726.6 ENSMUST00000031726.7 ENSMUST00000031726.8 ENSMUST00000031726.9 Gnb2 NM_010312 Q3U9V4 Q3U9V4_MOUSE uc009act.1 uc009act.2 uc009act.3 Belongs to the WD repeat G protein beta family. calcium channel regulator activity signal transduction macromolecular complex cell body macromolecular complex binding perinuclear region of cytoplasm GTPase binding uc009act.1 uc009act.2 uc009act.3 
ENSMUST00000031727.10 Gigyf1 ENSMUST00000031727.10 GRB10 interacting GYF protein 1, transcript variant 1 (from RefSeq NM_031408.3) ENSMUST00000031727.1 ENSMUST00000031727.2 ENSMUST00000031727.3 ENSMUST00000031727.4 ENSMUST00000031727.5 ENSMUST00000031727.6 ENSMUST00000031727.7 ENSMUST00000031727.8 ENSMUST00000031727.9 GGYF1_MOUSE Kiaa4110 NM_031408 Perq1 Q571A0 Q6Y7W9 Q99MR1 uc009acq.1 uc009acq.2 uc009acq.3 May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1. Interacts with GRB10 (PubMed:12771153). This transient binding is increased under IGF1 stimulation and leads to recruitment of GIGYF1/GRB10 complex to IGF1 receptor (PubMed:12771153). Interacts with DDX6 (By similarity). Ubiquitous. Lower expression in skeletal muscle, liver and testis. Belongs to the GIGYF family. Sequence=AAK28827.1; Type=Erroneous gene model prediction; Evidence=; protein binding macromolecular complex insulin-like growth factor receptor signaling pathway uc009acq.1 uc009acq.2 uc009acq.3 
ENSMUST00000031728.5 Pop7 ENSMUST00000031728.5 Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. (from UniProt Q9DCH2) AK002782 ENSMUST00000031728.1 ENSMUST00000031728.2 ENSMUST00000031728.3 ENSMUST00000031728.4 POP7_MOUSE Q9DCH2 Rpp20 uc009aco.1 uc009aco.2 uc009aco.3 Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA. Nucleus, nucleolus Cytoplasm Cytoplasmic granule Note=Under stress conditions colocalizes with SMN1 in punctuated cytoplasmic granules. Belongs to the histone-like Alba family. ribonuclease MRP complex tRNA 5'-leader removal nucleic acid binding ribonuclease P activity nucleus nucleolus cytoplasm rRNA processing tRNA processing hydrolase activity multimeric ribonuclease P complex ribonuclease P RNA binding RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc009aco.1 uc009aco.2 uc009aco.3 
ENSMUST00000031731.14 Pcolce ENSMUST00000031731.14 procollagen C-endopeptidase enhancer protein (from RefSeq NM_008788.2) ENSMUST00000031731.1 ENSMUST00000031731.10 ENSMUST00000031731.11 ENSMUST00000031731.12 ENSMUST00000031731.13 ENSMUST00000031731.2 ENSMUST00000031731.3 ENSMUST00000031731.4 ENSMUST00000031731.5 ENSMUST00000031731.6 ENSMUST00000031731.7 ENSMUST00000031731.8 ENSMUST00000031731.9 NM_008788 O35113 PCOC1_MOUSE Pcpe1 Q61398 uc009adb.1 uc009adb.2 uc009adb.3 Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. Interacts with EFEMP2. Secreted. Expressed in interstitial connective tissues like tendons, calvaria, skin and at a lower level in heart and skeletal muscle. Processed from a 55 kDa form to 36 kDa and 34 kDa forms. Sequence=CAA40612.1; Type=Frameshift; Evidence=; collagen binding extracellular region extracellular space proteolysis heparin binding positive regulation of peptidase activity peptidase activator activity cellular response to leukemia inhibitory factor uc009adb.1 uc009adb.2 uc009adb.3 
ENSMUST00000031732.14 Fbxo24 ENSMUST00000031732.14 F-box protein 24 (from RefSeq NM_027708.1) ENSMUST00000031732.1 ENSMUST00000031732.10 ENSMUST00000031732.11 ENSMUST00000031732.12 ENSMUST00000031732.13 ENSMUST00000031732.2 ENSMUST00000031732.3 ENSMUST00000031732.4 ENSMUST00000031732.5 ENSMUST00000031732.6 ENSMUST00000031732.7 ENSMUST00000031732.8 ENSMUST00000031732.9 FBX24_MOUSE Fbx24 NM_027708 Q9D417 uc009adc.1 uc009adc.2 uc009adc.3 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Directly interacts with SKP1 and CUL1. molecular_function cellular_component biological_process uc009adc.1 uc009adc.2 uc009adc.3 
ENSMUST00000031734.16 Lrch4 ENSMUST00000031734.16 leucine-rich repeats and calponin homology (CH) domain containing 4, transcript variant 1 (from RefSeq NM_146164.2) ENSMUST00000031734.1 ENSMUST00000031734.10 ENSMUST00000031734.11 ENSMUST00000031734.12 ENSMUST00000031734.13 ENSMUST00000031734.14 ENSMUST00000031734.15 ENSMUST00000031734.2 ENSMUST00000031734.3 ENSMUST00000031734.4 ENSMUST00000031734.5 ENSMUST00000031734.6 ENSMUST00000031734.7 ENSMUST00000031734.8 ENSMUST00000031734.9 H3BLL3 LRCH4_MOUSE NM_146164 Q921G6 uc291axw.1 uc291axw.2 Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. Cell membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q921G6-1; Sequence=Displayed; Name=2; IsoId=Q921G6-2; Sequence=VSP_061971, VSP_061972; Widely expressed across tissues, with the most abundant expression in spleen, testes, thymus, intestine, and blood (PubMed:30523158). Expressed in macrophages (PubMed:30523158). Expression is inhibited by LPS. protein binding cytoplasm PML body negative regulation of transcription, DNA-templated uc291axw.1 uc291axw.2 
ENSMUST00000031739.6 Ppp1r35 ENSMUST00000031739.6 protein phosphatase 1, regulatory subunit 35, transcript variant 1 (from RefSeq NM_027242.5) ENSMUST00000031739.1 ENSMUST00000031739.2 ENSMUST00000031739.3 ENSMUST00000031739.4 ENSMUST00000031739.5 NM_027242 PPR35_MOUSE Ppp1r35 Q9D8C8 uc009adx.1 uc009adx.2 uc009adx.3 During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with TTTN, leading to the centriole to centrosome conversion (By similarity). In addition may play a role in the primary cilia assembly (PubMed:32628936). Interacts with PPP1CA; this interaction mediates the PPP1CA phosphatase activity inhibition. Interacts with RTTN; this interaction allows the mutual recruitment to the centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Recruited to the nascent daughter centriole early in the duplication cycle and localizes to the proximal centriolar lumen just above the cartwheel. Co-localizes with RTTN at the centriole. Expressed throughout much of the embryo at 7.5 dpc, in mesoderm and ectoderm-derived structures at 8.5 dpc, and throughout much of the embryo at 9.5 dpc but is absent in the extra- embryonic visceral endoderm (VE) at all stages. Mice homozygous embryos for the Ppp1r35 gene are lethal during early embryogenesis (PubMed:32628936). Homozygous embryos are capable of initiating and completing gastrulation as well as specifying the anterior/posterior and the dorsal/ventral axis, but exhibit a developmental delays which are the result in the failure to progress past 8.5 dpc to 9.0 dpc (PubMed:32628936). Belongs to the PPP1R35 family. protein phosphatase inhibitor activity cellular_component negative regulation of phosphatase activity phosphatase binding negative regulation of phosphoprotein phosphatase activity uc009adx.1 uc009adx.2 uc009adx.3 
ENSMUST00000031740.16 Mepce ENSMUST00000031740.16 methylphosphate capping enzyme, transcript variant 4 (from RefSeq NR_188808.1) Bcdin3 Bipl1 D5Wsu46e ENSMUST00000031740.1 ENSMUST00000031740.10 ENSMUST00000031740.11 ENSMUST00000031740.12 ENSMUST00000031740.13 ENSMUST00000031740.14 ENSMUST00000031740.15 ENSMUST00000031740.2 ENSMUST00000031740.3 ENSMUST00000031740.4 ENSMUST00000031740.5 ENSMUST00000031740.6 ENSMUST00000031740.7 ENSMUST00000031740.8 ENSMUST00000031740.9 MEPCE_MOUSE Mepce NR_188808 Q2YFS5 Q3U465 Q3UT64 Q8K3A9 Q91W35 uc009ady.1 uc009ady.2 uc009ady.3 S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (By similarity). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:23154982). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (By similarity). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (By similarity). MEPCE has a non-enzymatic function in the 7SK RNP complex; it has a non-enzymatic function; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (By similarity). Reaction=a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S- adenosyl-L-methionine = a 5'-end methyltriphosphate-guanosine- ribonucleotide-snRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:58780, Rhea:RHEA-COMP:15220, Rhea:RHEA-COMP:15221, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138278, ChEBI:CHEBI:142789; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58781; Evidence=; Core component of the 7SK RNP complex, at least composed of 7SK RNA, LARP7, MEPCE, HEXIM1 (or HEXIM2) and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1). Interacts with METTL16. Interacts with RBM7; upon genotoxic stress this interaction is enhanced, triggering the release of inactive P-TEFb complex from the core, yielding to P-TEFb complex activation. Nucleus Belongs to the methyltransferase superfamily. Sequence=AAH17157.2; Type=Erroneous initiation; Evidence=; Sequence=AAX39492.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA methylation cellular_component methyltransferase activity O-methyltransferase activity RNA methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity snRNA metabolic process transferase activity snRNA binding methylation negative regulation of chromatin binding snRNA modification positive regulation of G1/S transition of mitotic cell cycle uc009ady.1 uc009ady.2 uc009ady.3 
ENSMUST00000031741.8 Cyp3a13 ENSMUST00000031741.8 cytochrome P450, family 3, subfamily a, polypeptide 13 (from RefSeq NM_007819.4) CP3AD_MOUSE Cyp3a-13 ENSMUST00000031741.1 ENSMUST00000031741.2 ENSMUST00000031741.3 ENSMUST00000031741.4 ENSMUST00000031741.5 ENSMUST00000031741.6 ENSMUST00000031741.7 NM_007819 Q64464 uc009aef.1 uc009aef.2 uc009aef.3 uc009aef.4 Can activate aflatoxin B1 to a genotoxic product. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. Belongs to the cytochrome P450 family. lipid hydroxylation monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane steroid metabolic process estrogen metabolic process steroid hydroxylase activity retinoic acid 4-hydroxylase activity positive regulation of gene expression membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding organelle membrane retinoic acid metabolic process intracellular membrane-bounded organelle metal ion binding testosterone 6-beta-hydroxylase activity oxidation-reduction process aromatase activity oxidative demethylation estrogen 16-alpha-hydroxylase activity estrogen 2-hydroxylase activity uc009aef.1 uc009aef.2 uc009aef.3 uc009aef.4 
ENSMUST00000031749.16 Nobox ENSMUST00000031749.16 NOBOX oogenesis homeobox (from RefSeq NM_130869.3) ENSMUST00000031749.1 ENSMUST00000031749.10 ENSMUST00000031749.11 ENSMUST00000031749.12 ENSMUST00000031749.13 ENSMUST00000031749.14 ENSMUST00000031749.15 ENSMUST00000031749.2 ENSMUST00000031749.3 ENSMUST00000031749.4 ENSMUST00000031749.5 ENSMUST00000031749.6 ENSMUST00000031749.7 ENSMUST00000031749.8 ENSMUST00000031749.9 NM_130869 NOBOX_MOUSE Og2x P70367 Q8VIH1 uc009bsp.1 uc009bsp.2 Transcription factor which plays an essential role in postnatal follicle development. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Directly regulates the transcription of POU5F1 and GDF9 during early folliculogenesis. Nucleus. Specifically expressed in ovaries and testes. In ovaries, expressed in oocytes from primordial through antral follicles but not in granulosa cells, theca cells and corpora lutea. Expressed from 15.5 dpc. Male mice are fertile and show no obvious abnormality. Female mice lacking Nobox have normal gross anatomy and histology, but are infertile with atrophic ovaries that lack oocytes at 6 weeks of age. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ovarian follicle development DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex cytoplasm regulation of transcription from RNA polymerase II promoter multicellular organism development cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter oogenesis uc009bsp.1 uc009bsp.2 
ENSMUST00000031750.14 Arhgef5 ENSMUST00000031750.14 Rho guanine nucleotide exchange factor 5, transcript variant 1 (from RefSeq NM_133674.2) ARHG5_MOUSE Arhgef5 E9Q7D5 ENSMUST00000031750.1 ENSMUST00000031750.10 ENSMUST00000031750.11 ENSMUST00000031750.12 ENSMUST00000031750.13 ENSMUST00000031750.2 ENSMUST00000031750.3 ENSMUST00000031750.4 ENSMUST00000031750.5 ENSMUST00000031750.6 ENSMUST00000031750.7 ENSMUST00000031750.8 ENSMUST00000031750.9 NM_133674 Q8R172 Q922T1 uc009bso.1 uc009bso.2 uc009bso.3 uc009bso.4 Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:19713215, PubMed:21525037). Strongly activates RHOA (PubMed:19713215, PubMed:21525037). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (PubMed:19713215). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:21525037). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (By similarity). Required for SRC-induced podosome formation (PubMed:21525037). Involved in positive regulation of immature dendritic cell migration (PubMed:19713215). Interacts with SRC (PubMed:21525037). Forms a ternary complex with SRC and the PI3K 85 kDa subunit (PubMed:21525037). Interacts with and is activated by the heterodimer formed by GNB1 and GNG2 (PubMed:19713215). Interacts with ODAM (via C-terminus) (By similarity). Interacts with RHOA (PubMed:19713215). Nucleus Cytoplasm Cell projection, podosome The PH domain binds to phosphoinositides and is essential for podosome formation. Activation of SRC induces tyrosine phosphorylation of ARHGEF5. Chemotaxis of macrophages, T and B lymphocytes and bone marrow-derived mature dendritic cells from mutant mice is not affected but chemotaxis of immature dendritic cells is abolished. podosome myeloid dendritic cell chemotaxis guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane lipid binding actin cytoskeleton organization cell junction regulation of actin cytoskeleton organization regulation of Rho protein signal transduction intracellular signal transduction cell projection regulation of GTPase activity positive regulation of JUN kinase activity positive regulation of GTPase activity positive regulation of sequence-specific DNA binding transcription factor activity regulation of cytoskeleton organization positive regulation of stress fiber assembly positive regulation of podosome assembly cell periphery positive regulation of protein import uc009bso.1 uc009bso.2 uc009bso.3 uc009bso.4 
ENSMUST00000031766.12 Asns ENSMUST00000031766.12 asparagine synthetase, transcript variant 1 (from RefSeq NM_012055.5) ASNS_MOUSE ENSMUST00000031766.1 ENSMUST00000031766.10 ENSMUST00000031766.11 ENSMUST00000031766.2 ENSMUST00000031766.3 ENSMUST00000031766.4 ENSMUST00000031766.5 ENSMUST00000031766.6 ENSMUST00000031766.7 ENSMUST00000031766.8 ENSMUST00000031766.9 NM_012055 Q3TJA1 Q61024 Q8BPC8 uc009axf.1 uc009axf.2 uc009axf.3 Reaction=ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate; Xref=Rhea:RHEA:12228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58048, ChEBI:CHEBI:58359, ChEBI:CHEBI:456215; EC=6.3.5.4; Amino-acid biosynthesis; L-asparagine biosynthesis; L- asparagine from L-aspartate (L-Gln route): step 1/1. Mice carrying a gene trap insertion in the gene express 20% of the normal level of mRNA. The hypomorphic mutant displays a number of defects that mirror ASNSD syndrome, although the phenotype is milder. Mice have structural brain abnormalities, including reduced cortical thickness and enlarged ventricles. Mutant mice also show deficits in learning and memory. Mutant mice do not show abnormal motor activity or seizure activity. nucleotide binding liver development asparagine synthase (glutamine-hydrolyzing) activity ATP binding cytosol cellular amino acid metabolic process asparagine biosynthetic process glutamine metabolic process cellular amino acid biosynthetic process response to light stimulus response to mechanical stimulus response to toxic substance ligase activity response to methotrexate response to nutrient levels response to follicle-stimulating hormone cellular response to hormone stimulus cellular response to glucose starvation protein homodimerization activity negative regulation of apoptotic process response to amino acid positive regulation of mitotic cell cycle cofactor binding L-asparagine biosynthetic process uc009axf.1 uc009axf.2 uc009axf.3 
ENSMUST00000031773.9 Pon3 ENSMUST00000031773.9 paraoxonase 3, transcript variant 1 (from RefSeq NM_173006.3) ENSMUST00000031773.1 ENSMUST00000031773.2 ENSMUST00000031773.3 ENSMUST00000031773.4 ENSMUST00000031773.5 ENSMUST00000031773.6 ENSMUST00000031773.7 ENSMUST00000031773.8 NM_173006 PON3_MOUSE Q4FZK0 Q62087 Q8C2I7 uc009awe.1 uc009awe.2 uc009awe.3 Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity). Reaction=a phenyl acetate + H2O = a phenol + acetate + H(+); Xref=Rhea:RHEA:17309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:33853, ChEBI:CHEBI:140310; EC=3.1.1.2; Evidence=; Reaction=An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.; EC=3.1.8.1; Evidence=; Reaction=an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H(+); Xref=Rhea:RHEA:22576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:55474, ChEBI:CHEBI:58921; EC=3.1.1.81; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 calcium ions per subunit. ; Homodimer. Secreted, extracellular space Glycosylated. The signal sequence is not cleaved. Belongs to the paraoxonase family. aryldialkylphosphatase activity arylesterase activity extracellular region extracellular space response to toxic substance phenylacetate catabolic process dephosphorylation hydrolase activity 3,4-dihydrocoumarin hydrolase activity aromatic compound catabolic process negative regulation of superoxide anion generation protein homodimerization activity intracellular membrane-bounded organelle coumarin catabolic process carboxylic acid catabolic process metal ion binding acyl-L-homoserine-lactone lactonohydrolase activity uc009awe.1 uc009awe.2 uc009awe.3 
ENSMUST00000031778.6 1700012A03Rik ENSMUST00000031778.6 RIKEN cDNA 1700012A03 gene (from RefSeq NM_029587.3) 1700012A03Rik ENSMUST00000031778.1 ENSMUST00000031778.2 ENSMUST00000031778.3 ENSMUST00000031778.4 ENSMUST00000031778.5 NM_029587 Q9DAF1 Q9DAF1_MOUSE uc009bgk.1 uc009bgk.2 uc009bgk.3 molecular_function cellular_component biological_process uc009bgk.1 uc009bgk.2 uc009bgk.3 
ENSMUST00000031779.17 Calu ENSMUST00000031779.17 calumenin, transcript variant 1 (from RefSeq NM_007594.4) Calu ENSMUST00000031779.1 ENSMUST00000031779.10 ENSMUST00000031779.11 ENSMUST00000031779.12 ENSMUST00000031779.13 ENSMUST00000031779.14 ENSMUST00000031779.15 ENSMUST00000031779.16 ENSMUST00000031779.2 ENSMUST00000031779.3 ENSMUST00000031779.4 ENSMUST00000031779.5 ENSMUST00000031779.6 ENSMUST00000031779.7 ENSMUST00000031779.8 ENSMUST00000031779.9 NM_007594 Q3TUF3 Q3TUF3_MOUSE uc009bdg.1 uc009bdg.2 uc009bdg.3 Endoplasmic reticulum membrane Golgi apparatus Melanosome Membrane Sarcoplasmic reticulum lumen Belongs to the CREC family. calcium ion binding endoplasmic reticulum uc009bdg.1 uc009bdg.2 uc009bdg.3 
ENSMUST00000031787.8 Evx1 ENSMUST00000031787.8 even-skipped homeobox 1 (from RefSeq NM_007966.4) ENSMUST00000031787.1 ENSMUST00000031787.2 ENSMUST00000031787.3 ENSMUST00000031787.4 ENSMUST00000031787.5 ENSMUST00000031787.6 ENSMUST00000031787.7 EVX1_MOUSE NM_007966 P23683 uc009byv.1 uc009byv.2 May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. Nucleus. Shows a graded distribution in the primitive streak and in cells lateral to it. It is not detected in cells along the A-P axis of the embryo anterior to the primitive streak, except at 7.5 dpc when there is transient expression in the head process. The highest levels of expression are found within the proximal (posterior) portion of the primitive streak and cells near it, with expression levels decreasing more distally (anteriorly). Belongs to the even-skipped homeobox family. DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development embryo development ending in birth or egg hatching regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc009byv.1 uc009byv.2 
ENSMUST00000031788.9 Hibadh ENSMUST00000031788.9 3-hydroxyisobutyrate dehydrogenase (from RefSeq NM_145567.1) 3HIDH_MOUSE ENSMUST00000031788.1 ENSMUST00000031788.2 ENSMUST00000031788.3 ENSMUST00000031788.4 ENSMUST00000031788.5 ENSMUST00000031788.6 ENSMUST00000031788.7 ENSMUST00000031788.8 NM_145567 Q8BJY2 Q99L13 uc009byw.1 uc009byw.2 uc009byw.3 Reaction=3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3- oxopropanoate + H(+) + NADH; Xref=Rhea:RHEA:17681, ChEBI:CHEBI:11805, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57700, ChEBI:CHEBI:57945; EC=1.1.1.31; Amino-acid degradation; L-valine degradation. Homodimer. Mitochondrion Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. mitochondrion valine catabolic process 3-hydroxyisobutyrate dehydrogenase activity branched-chain amino acid catabolic process oxidoreductase activity NADP binding NAD binding oxidation-reduction process uc009byw.1 uc009byw.2 uc009byw.3 
ENSMUST00000031793.8 Nt5c3 ENSMUST00000031793.8 5'-nucleotidase, cytosolic III, transcript variant 1 (from RefSeq NM_026004.3) 5NT3A_MOUSE ENSMUST00000031793.1 ENSMUST00000031793.2 ENSMUST00000031793.3 ENSMUST00000031793.4 ENSMUST00000031793.5 ENSMUST00000031793.6 ENSMUST00000031793.7 NM_026004 Nt5c3a Q8CI05 Q9D020 Q9D0D9 uc009cbr.1 uc009cbr.2 uc009cbr.3 uc009cbr.4 uc009cbr.5 Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate. Reaction=H2O + N(7)-methyl-GMP = N(7)-methylguanosine + phosphate; Xref=Rhea:RHEA:37107, ChEBI:CHEBI:15377, ChEBI:CHEBI:20794, ChEBI:CHEBI:43474, ChEBI:CHEBI:58285; EC=3.1.3.91; Evidence=; Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377, ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5; Evidence=; Monomer. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q9D020-3; Sequence=Displayed; Name=1; IsoId=Q9D020-1; Sequence=VSP_021566; Isoform 2 is highly expressed in the brain, heart, spleen, kidney and blood. Isoform 2 is expressed (at protein level) in the spleen, skeletal muscle and gastrointestinal epithelia. Isoform 2 is weakly expressed from 7.5 dpc and the expression level steadily increases through gestation. At 9.5 dpc and 10.5 dpc is first detected colocalizing with embryonic blood cells within the region of the septum transversum and within the cardiac chambers and dorsal aorta. At 12.5 dpc expression is found in the ventral neural tube and in the trigeminal ganglia and in the liver and dorsal root ganglia. Expression persists in the liver, dorsal root and trigeminal ganglia at 13.5 dpc and weaker expression becomes apparent in cardiac and skeletal muscle. At 16.5 dpc expression is detected in liver, myocardium, tongue, bronchial epithelium, gastrointestinal epithelium, cartilage and forebrain neuroepithelium. Belongs to the pyrimidine 5'-nucleotidase family. nucleotide binding magnesium ion binding cytoplasm mitochondrion endoplasmic reticulum 5'-nucleotidase activity nucleotide metabolic process dephosphorylation transferase activity hydrolase activity adenosine metabolic process metal ion binding defense response to virus uc009cbr.1 uc009cbr.2 uc009cbr.3 uc009cbr.4 uc009cbr.5 
ENSMUST00000031795.8 Fkbp9 ENSMUST00000031795.8 FK506 binding protein 9 (from RefSeq NM_012056.2) ENSMUST00000031795.1 ENSMUST00000031795.2 ENSMUST00000031795.3 ENSMUST00000031795.4 ENSMUST00000031795.5 ENSMUST00000031795.6 ENSMUST00000031795.7 FKBP9_MOUSE Fkbp60 Fkbp63 NM_012056 Q80ZZ6 Q8R386 Q9CVM0 Q9JHX5 Q9Z247 uc009cbp.1 uc009cbp.2 uc009cbp.3 uc009cbp.4 PPIases accelerate the folding of proteins during protein synthesis. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Inhibited by FK506. Endoplasmic reticulum lumen Predominantly expressed in heart, skeletal muscle, lung, liver and kidney. Lower levels found in brain, spleen and testis. Expressed in all developmental stages. Phosphorylated. protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity calcium ion binding endoplasmic reticulum endoplasmic reticulum lumen protein folding isomerase activity metal ion binding uc009cbp.1 uc009cbp.2 uc009cbp.3 uc009cbp.4 
ENSMUST00000031798.14 Ssmem1 ENSMUST00000031798.14 serine-rich single-pass membrane protein 1, transcript variant 2 (from RefSeq NM_029373.4) 1700025E21Rik ENSMUST00000031798.1 ENSMUST00000031798.10 ENSMUST00000031798.11 ENSMUST00000031798.12 ENSMUST00000031798.13 ENSMUST00000031798.2 ENSMUST00000031798.3 ENSMUST00000031798.4 ENSMUST00000031798.5 ENSMUST00000031798.6 ENSMUST00000031798.7 ENSMUST00000031798.8 ENSMUST00000031798.9 NM_029373 Q9D9Y8 Q9D9Y8_MOUSE Ssmem1 uc009bfm.1 uc009bfm.2 uc009bfm.3 uc009bfm.4 molecular_function cellular_component biological_process membrane integral component of membrane uc009bfm.1 uc009bfm.2 uc009bfm.3 uc009bfm.4 
ENSMUST00000031805.11 Avl9 ENSMUST00000031805.11 AVL9 cell migration associated (from RefSeq NM_030235.1) AVL9_MOUSE ENSMUST00000031805.1 ENSMUST00000031805.10 ENSMUST00000031805.2 ENSMUST00000031805.3 ENSMUST00000031805.4 ENSMUST00000031805.5 ENSMUST00000031805.6 ENSMUST00000031805.7 ENSMUST00000031805.8 ENSMUST00000031805.9 Kiaa0241 NM_030235 Q149B3 Q80U56 uc009cbl.1 uc009cbl.2 uc009cbl.3 uc009cbl.4 Functions in cell migration. Recycling endosome Membrane ; Single-pass membrane protein Belongs to the AVL9 family. Sequence=BAC65510.1; Type=Erroneous initiation; Evidence=; molecular_function endosome membrane integral component of membrane cell migration recycling endosome uc009cbl.1 uc009cbl.2 uc009cbl.3 uc009cbl.4 
ENSMUST00000031806.10 Cpa1 ENSMUST00000031806.10 carboxypeptidase A1, pancreatic (from RefSeq NM_025350.4) CBPA1_MOUSE ENSMUST00000031806.1 ENSMUST00000031806.2 ENSMUST00000031806.3 ENSMUST00000031806.4 ENSMUST00000031806.5 ENSMUST00000031806.6 ENSMUST00000031806.7 ENSMUST00000031806.8 ENSMUST00000031806.9 NM_025350 Q7TPZ8 uc009bfq.1 uc009bfq.2 uc009bfq.3 uc009bfq.4 This gene encodes carboxypeptidase A, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme. This gene is expressed in pancreas, the encoded protein is a major component of digestive enzymes secreted by pancreas and plays an important role in the process of digestion. This gene is located in a cluster of related carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jan 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052661.1, AK003088.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. Reaction=Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.; EC=3.4.17.1; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Monomer. Secreted Belongs to the peptidase M14 family. carboxypeptidase activity metallocarboxypeptidase activity extracellular region extracellular space proteolysis peptidase activity metallopeptidase activity exopeptidase activity zinc ion binding hydrolase activity metal ion binding uc009bfq.1 uc009bfq.2 uc009bfq.3 uc009bfq.4 
ENSMUST00000031810.15 Cep41 ENSMUST00000031810.15 centrosomal protein 41, transcript variant 1 (from RefSeq NM_031998.3) CEP41_MOUSE D3Z3U1 ENSMUST00000031810.1 ENSMUST00000031810.10 ENSMUST00000031810.11 ENSMUST00000031810.12 ENSMUST00000031810.13 ENSMUST00000031810.14 ENSMUST00000031810.2 ENSMUST00000031810.3 ENSMUST00000031810.4 ENSMUST00000031810.5 ENSMUST00000031810.6 ENSMUST00000031810.7 ENSMUST00000031810.8 ENSMUST00000031810.9 F7CSA6 NM_031998 Q3TTB5 Q8BT53 Q99NF3 Tsga14 uc009bfr.1 uc009bfr.2 uc009bfr.3 This gene encodes a centrosomal protein which may be required for tubulin glutamylation in cilia during ciliogenesis. Mutations in a similar gene in human have been associated with Joubert Syndrome 15, an autosomal recessive ciliopathy and neurological disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]. Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. Found in a complex with TTLL6. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Note=Localizes mainly to the cilium basal body and in primary cilia. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99NF3-1; Sequence=Displayed; Name=2; IsoId=Q99NF3-2; Sequence=VSP_012249, VSP_012250; At 10-13 dpc, embryos show a range of phenotypes, such as malformed hindbrain, exencephaly, brain hemorrhage, dilated pericardial sac and lethality. For an unclear reason, some homozygous mutants develop normally, suggesting presence of extragenic phenotypic modifiers. Belongs to the CEP41 family. molecular_function cytoplasm centrosome centriole microtubule organizing center cytoskeleton cilium protein transport protein polyglutamylation cell projection organization ciliary basal body cell projection cilium assembly uc009bfr.1 uc009bfr.2 uc009bfr.3 
ENSMUST00000031817.10 Herc6 ENSMUST00000031817.10 hect domain and RLD 6 (from RefSeq NM_025992.2) ENSMUST00000031817.1 ENSMUST00000031817.2 ENSMUST00000031817.3 ENSMUST00000031817.4 ENSMUST00000031817.5 ENSMUST00000031817.6 ENSMUST00000031817.7 ENSMUST00000031817.8 ENSMUST00000031817.9 F2Z461 HERC6_MOUSE NM_025992 Q3UEA7 Q9CU70 uc009ccj.1 uc009ccj.2 uc009ccj.3 uc009ccj.4 Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Cytoplasm, cytosol Note=Exclusively cytoplasmic. By type I interferons. Abolishes global ISGylation. hematopoietic progenitor cell differentiation immune system process ubiquitin-protein transferase activity nucleus cytoplasm cytosol response to bacterium protein ubiquitination transferase activity cyclin binding innate immune response ubiquitin protein ligase activity uc009ccj.1 uc009ccj.2 uc009ccj.3 uc009ccj.4 
ENSMUST00000031822.13 Abcg2 ENSMUST00000031822.13 ATP binding cassette subfamily G member 2 (Junior blood group), transcript variant 1 (from RefSeq NM_011920.3) A0A0R4J0B6 A0A0R4J0B6_MOUSE Abcg2 ENSMUST00000031822.1 ENSMUST00000031822.10 ENSMUST00000031822.11 ENSMUST00000031822.12 ENSMUST00000031822.2 ENSMUST00000031822.3 ENSMUST00000031822.4 ENSMUST00000031822.5 ENSMUST00000031822.6 ENSMUST00000031822.7 ENSMUST00000031822.8 ENSMUST00000031822.9 NM_011920 uc009cdb.1 uc009cdb.2 uc009cdb.3 The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no full-length transcript from the C57BL/6J reference strain was available. The extent of this transcript is supported by its existence in a single strain, C57BL/6NCrl. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053730.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## Membrane ; Multi- pass membrane protein Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. nucleotide binding ATP binding nucleus plasma membrane aging cytoskeletal protein binding response to iron ion urate transport drug transport membrane integral component of membrane apical plasma membrane ATPase activity glucuronoside metabolic process response to lipopolysaccharide response to insulin ATPase activity, coupled to transmembrane movement of substances response to morphine drug export protein dimerization activity response to folic acid transmembrane transport embryonic process involved in female pregnancy cellular response to estradiol stimulus cellular response to dexamethasone stimulus urate salt excretion negative regulation of intestinal absorption response to 2,3,7,8-tetrachlorodibenzodioxine uc009cdb.1 uc009cdb.2 uc009cdb.3 
ENSMUST00000031835.14 Aoc1 ENSMUST00000031835.14 amine oxidase, copper-containing 1, transcript variant 3 (from RefSeq NM_029638.2) Abp1 Aoc1 E9PYN9 E9PYN9_MOUSE ENSMUST00000031835.1 ENSMUST00000031835.10 ENSMUST00000031835.11 ENSMUST00000031835.12 ENSMUST00000031835.13 ENSMUST00000031835.2 ENSMUST00000031835.3 ENSMUST00000031835.4 ENSMUST00000031835.5 ENSMUST00000031835.6 ENSMUST00000031835.7 ENSMUST00000031835.8 ENSMUST00000031835.9 NM_029638 uc012elk.1 uc012elk.2 uc012elk.3 Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Note=Contains 1 topaquinone per subunit. ; Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. Belongs to the copper/topaquinone oxidase family. copper ion binding primary amine oxidase activity amine metabolic process oxidoreductase activity metal ion binding quinone binding oxidation-reduction process uc012elk.1 uc012elk.2 uc012elk.3 
ENSMUST00000031837.8 Aoc1l2 ENSMUST00000031837.8 amine oxidase copper containing 1-like 2 (from RefSeq NM_001081273.2) 1600015I10Rik Aoc1l2 Doxl1 E9Q745 E9Q745_MOUSE ENSMUST00000031837.1 ENSMUST00000031837.2 ENSMUST00000031837.3 ENSMUST00000031837.4 ENSMUST00000031837.5 ENSMUST00000031837.6 ENSMUST00000031837.7 NM_001081273 uc012elm.1 uc012elm.2 uc012elm.3 Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Note=Contains 1 topaquinone per subunit. ; Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. Belongs to the copper/topaquinone oxidase family. copper ion binding plasma membrane primary amine oxidase activity amine metabolic process oxidoreductase activity response to antibiotic metal ion binding quinone binding diamine oxidase activity oxidation-reduction process uc012elm.1 uc012elm.2 uc012elm.3 
ENSMUST00000031838.9 Igf2bp3 ENSMUST00000031838.9 insulin-like growth factor 2 mRNA binding protein 3 (from RefSeq NM_023670.3) ENSMUST00000031838.1 ENSMUST00000031838.2 ENSMUST00000031838.3 ENSMUST00000031838.4 ENSMUST00000031838.5 ENSMUST00000031838.6 ENSMUST00000031838.7 ENSMUST00000031838.8 IF2B3_MOUSE NM_023670 Q3UHZ6 Q8C2J9 Q9CPN8 Vickz3 uc009bwi.1 uc009bwi.2 uc009bwi.3 uc009bwi.4 RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6- methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation (By similarity). Binds to beta-actin/ACTB and MYC transcripts (By similarity). Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Interacts with IGF2BP1. Interacts with ELAVL1, DHX9, HNRNPU, MATR3 and PABPC1. Nucleus toplasm Cytoplasm, P- body Cytoplasm, Stress granule Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules. Expressed in oocytes, spermatogonia and spermatocytes (at protein level). Expressed in zygotes and blastocysts (at protein level). Expressed in gonads at 12.5 and 14.5 dpc (at protein level). Expressed in germ cells at 16.5 dpc (at protein level). Expressed in brain at 10.5 dpc and declining towards birth (at protein level). Expressed during fetal development at 7, 9.5, 10.5, 12.5, 14.5 and 17.5 dpc and declining towards birth. All KH domains contribute binding to target mRNA. Domains KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 also contribute. The KH domains are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules. Belongs to the RRM IMP/VICKZ family. nucleic acid binding RNA binding mRNA 3'-UTR binding protein binding nucleus cytoplasm cytosol regulation of translation mRNA 5'-UTR binding mRNA transport uc009bwi.1 uc009bwi.2 uc009bwi.3 uc009bwi.4 
ENSMUST00000031843.7 Npy ENSMUST00000031843.7 neuropeptide Y (from RefSeq NM_023456.3) ENSMUST00000031843.1 ENSMUST00000031843.2 ENSMUST00000031843.3 ENSMUST00000031843.4 ENSMUST00000031843.5 ENSMUST00000031843.6 NM_023456 NPY_MOUSE P57774 Q925V2 Q9ET27 uc009bwt.1 uc009bwt.2 uc009bwt.3 uc009bwt.4 This gene encodes a neuropeptide that plays a pivotal role in many physiological functions such as food intake, energy homeostasis, circadian rhythm, and cognition. The encoded protein precursor undergoes proteolytic processing to generate the biologically active peptide. Mice lacking the encoded protein exhibit mild seizures occasionally and become hyperphagic following food deprivation. A deficiency of the encoded protein partially prevents mice lacking leptin from becoming obese. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CO040096.1, CO040234.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla. The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Belongs to the NPY family. G-protein coupled receptor binding response to yeast hormone activity neuropeptide hormone activity extracellular region extracellular space cytoplasm Golgi apparatus neuropeptide signaling pathway regulation of blood pressure adult feeding behavior antibacterial humoral response antifungal humoral response central nervous system neuron development cerebral cortex development neuron projection development neuropeptide Y receptor binding positive regulation of appetite neuron projection terminal bouton perikaryon innate immune response perinuclear region of cytoplasm defense response to Gram-negative bacterium defense response to Gram-positive bacterium uc009bwt.1 uc009bwt.2 uc009bwt.3 uc009bwt.4 
ENSMUST00000031845.13 Gsdme ENSMUST00000031845.13 [Gasdermin-E]: Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis. (from UniProt Q9Z2D3) AK016561 Dfna5 Dfna5h ENSMUST00000031845.1 ENSMUST00000031845.10 ENSMUST00000031845.11 ENSMUST00000031845.12 ENSMUST00000031845.2 ENSMUST00000031845.3 ENSMUST00000031845.4 ENSMUST00000031845.5 ENSMUST00000031845.6 ENSMUST00000031845.7 ENSMUST00000031845.8 ENSMUST00000031845.9 GSDME_MOUSE Gsdme Q9Z2D3 uc009bwx.1 uc009bwx.2 uc009bwx.3 [Gasdermin-E]: Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis. [Gasdermin-E, N-terminal]: Pore-forming protein produced by cleavage by CASP3 or granzyme B (GZMB), which converts non-inflammatory apoptosis to pyroptosis or promotes granzyme-mediated pyroptosis, respectively (PubMed:32188940). After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukins (IL1B and IL16) and triggering pyroptosis (PubMed:33852854). Binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate (By similarity). Cleavage by CASP3 switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis (PubMed:32188940). Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents (PubMed:28045099). Exhibits bactericidal activity (By similarity). Cleavage by GZMB promotes tumor suppressor activity by triggering robust anti-tumor immunity (PubMed:32188940). Suppresses tumors by mediating granzyme-mediated pyroptosis in target cells of natural killer (NK) cells: cleavage by granzyme B (GZMB), delivered to target cells from NK-cells, triggers pyroptosis of tumor cells and tumor suppression (By similarity). May play a role in the p53/TP53-regulated cellular response to DNA damage (By similarity). [Gasdermin-E]: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C- terminal domains mediate autoinhibition in the absence of activation signal (By similarity). The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-E, N-terminal) following cleavage by CASP3 or granzyme B (GZMB) (By similarity). Activated by NLRP1 in the absence of GSDMD expression: NLRP1 cleaves and activates CASP8, promoting downstream activation of CASP3 and subsequent activation of GSDME (PubMed:33852854). [Gasdermin-E, N-terminal]: Homooligomer; homooligomeric ring- shaped pore complex containing 27-28 subunits when inserted in the membrane. [Gasdermin-E, N-terminal]: Cell membrane ; Multi-pass membrane protein [Gasdermin-E]: Cytoplasm, cytosol Expressed in spleen, kidney, large and small intestine, testicle, stomach and by CD4(+)CD(8+) T cells in thymus (PubMed:28459430). Expressed by macrophages (PubMed:28045099). Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N- terminal domain, that is released upon cleavage by CASP3 or granzyme B (GZMB). Cleavage at Asp-270 by CASP3 (mature and uncleaved precursor forms) or granzyme B (GZMB) relieves autoinhibition and is sufficient to initiate pyroptosis. [Gasdermin-E]: Succination by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits processing by caspases, and ability to initiate pyroptosis. Succination modification is catalyzed by a non-enzymatic reaction caused by an accumulation of fumarate. Mutant mice develop normally, including the immune system. After injection of the chemotherapy drug cisplatin, they look more healthy and vigorous than wild type. Belongs to the gasdermin family. phosphatidylinositol-4,5-bisphosphate binding cytoplasm cytosol plasma membrane sensory perception of sound cell death negative regulation of cell proliferation programmed cell death membrane positive regulation of MAPK cascade inner ear receptor cell differentiation necrotic cell death pyroptosis cellular response to tumor necrosis factor cellular response to virus cardiolipin binding positive regulation of intrinsic apoptotic signaling pathway uc009bwx.1 uc009bwx.2 uc009bwx.3 
ENSMUST00000031851.5 Tmem213 ENSMUST00000031851.5 transmembrane protein 213 (from RefSeq NM_029921.1) A0A0R4J0C3 A0A0R4J0C3_MOUSE ENSMUST00000031851.1 ENSMUST00000031851.2 ENSMUST00000031851.3 ENSMUST00000031851.4 NM_029921 Tmem213 uc009bjq.1 uc009bjq.2 uc009bjq.3 uc009bjq.4 membrane integral component of membrane uc009bjq.1 uc009bjq.2 uc009bjq.3 uc009bjq.4 
ENSMUST00000031852.5 Spmip4 ENSMUST00000031852.5 sperm microtubule inner protein 4, transcript variant 1 (from RefSeq NM_027564.4) C7orf31 ENSMUST00000031852.1 ENSMUST00000031852.2 ENSMUST00000031852.3 ENSMUST00000031852.4 NM_027564 Q8K4U1 Q9D5Y0 SMIP4_MOUSE uc009bxf.1 uc009bxf.2 uc009bxf.3 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, flagellum axoneme Note=Localizes to the A-tubules of DMTs. Predominantly expressed in the testes. The testis size, weight and histology, spermatogenesis, and sperm morphology and motility are normal in homozygous knockout males. Sequence=BAB97205.1; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton biological_process uc009bxf.1 uc009bxf.2 uc009bxf.3 
ENSMUST00000031853.8 Npvf ENSMUST00000031853.8 neuropeptide VF precursor (from RefSeq NM_021892.2) ENSMUST00000031853.1 ENSMUST00000031853.2 ENSMUST00000031853.3 ENSMUST00000031853.4 ENSMUST00000031853.5 ENSMUST00000031853.6 ENSMUST00000031853.7 NM_021892 NPVF_MOUSE Q920A4 Q9ESQ8 Rfrp uc009bxg.1 uc009bxg.2 uc009bxg.3 Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP. Neuropeptide NPVF blocks morphine-induced analgesia (By similarity). Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ESQ8-1; Sequence=Displayed; Name=2; IsoId=Q9ESQ8-2; Sequence=VSP_039963; Belongs to the FARP (FMRFamide related peptide) family. receptor binding extracellular region neuropeptide signaling pathway sensory perception of pain negative regulation of gonadotropin secretion uc009bxg.1 uc009bxg.2 uc009bxg.3 
ENSMUST00000031859.14 Trim24 ENSMUST00000031859.14 tripartite motif-containing 24, transcript variant 1 (from RefSeq NM_145076.4) ENSMUST00000031859.1 ENSMUST00000031859.10 ENSMUST00000031859.11 ENSMUST00000031859.12 ENSMUST00000031859.13 ENSMUST00000031859.2 ENSMUST00000031859.3 ENSMUST00000031859.4 ENSMUST00000031859.5 ENSMUST00000031859.6 ENSMUST00000031859.7 ENSMUST00000031859.8 ENSMUST00000031859.9 NM_145076 Q64126 Q64127 TIF1A_MOUSE Tif1 Tif1a uc009bjk.1 uc009bjk.2 uc009bjk.3 uc009bjk.4 The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes. Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (By similarity). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up- regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Participates also in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway. Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts (via bromo domain) with histone H3 (via N-terminus), provided that it is not methylated at 'Lys-4' (H3K4me0). Does not interact with histone H3 that is methylated at 'Lys-4' (H3K4me1, H3K4me2 or H3K4me3). Interacts (via bromo domain) with histone H3 (via N-terminus) that is acetylated at 'Lys-23' (H3K23ac). Has the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has very low affinity for histone H3 that is methylated at 'Lys-9' (H3K9me), or acetylated at both 'Lys- 9' (H3K9ac) and 'Lys-14' (H3K14ac), or acetylated at 'Lys-27' (H3K27ac) (in vitro). Interacts with TRIM16. Interacts with NR3C2/MCR (By similarity). Interacts with the ligand-binding domain of estrogen receptors (in vitro). Interaction with DNA-bound estrogen receptors requires the presence of estradiol (By similarity). Interacts with AR, CARM1, KAT5/TIP60, NCOA2/GRIP1, BRD7, CBX1, CBX3 and CBX5. Part of a coactivator complex containing TRIM24, NCOA2/GRIP1 and CARM1. Interacts with p53/TP53 and PML. Q64127; P83917: Cbx1; NbExp=4; IntAct=EBI-307947, EBI-78119; Q64127; Q61686: Cbx5; NbExp=4; IntAct=EBI-307947, EBI-307973; Q64127; P02340: Tp53; NbExp=2; IntAct=EBI-307947, EBI-474016; Q64127; Q99PP7: Trim33; NbExp=2; IntAct=EBI-307947, EBI-3043980; Nucleus toplasm Note=Detected in the cytoplasm of the zygote (PubMed:16880268). Translocates into the pronucleus at the time of genome activation (PubMed:16880268). Colocalizes with sites of active transcription (PubMed:10610177). Localizes to sites of DNA damage (By similarity). Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q64127-1; Sequence=Displayed; Name=Short; IsoId=Q64127-2; Sequence=VSP_005773; Detected in embryonic and adult liver. Detected in zygote and throughout embryogenesis (at protein level). Detected in all adult tissues, with the highest expression level in testis. Before puberty, highly expressed in liver from males and females. After puberty, expression is considerably higher in liver from females compared to males. Up-regulated in males by continuous exposure to growth hormone. Sumoylated. Phosphorylated at Ser-768 by ATM kinase induces ubiquitination and degradation during DNA damage. Undergoes ubiquitination-mediated degradation in response to DNA damage. Note=A chromosomal aberration involving TRIM24 produces a TRIM24-BRAF (T18) oncogene originally isolated from a furfural-induced hepatoma. No visible phenotype during the first few months. Impaired transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes. Hepatocytes continue to proliferate throughout adulthood. High incidence hypertrophic hepatocytes with enlarged nuclei after three months. After nine months, about half of the mice have hepatocellular adenomas. Very high incidence of hepatocarcinoma in 13 to 29 month old mice, increasing from 40% to 80%. When one copy of Rara is disrupted, mice do not develop liver tumors or liver dysplasia. p53 binding DNA binding chromatin binding transcription coactivator activity protein kinase activity ubiquitin-protein transferase activity protein binding nucleus nucleoplasm nuclear euchromatin perichromatin fibrils cytoplasm protein phosphorylation zinc ion binding negative regulation of cell proliferation positive regulation of gene expression protein ubiquitination transferase activity ligand-dependent nuclear receptor binding protein catabolic process regulation of protein stability estrogen response element binding regulation of apoptotic process sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated protein autophosphorylation metal ion binding calcium ion homeostasis ubiquitin protein ligase activity regulation of vitamin D receptor signaling pathway lysine-acetylated histone binding cellular response to estrogen stimulus regulation of signal transduction by p53 class mediator nucleolus uc009bjk.1 uc009bjk.2 uc009bjk.3 uc009bjk.4 
ENSMUST00000031862.14 Cbx3 ENSMUST00000031862.14 chromobox 3, transcript variant 1 (from RefSeq NM_007624.4) Cbx3 ENSMUST00000031862.1 ENSMUST00000031862.10 ENSMUST00000031862.11 ENSMUST00000031862.12 ENSMUST00000031862.13 ENSMUST00000031862.2 ENSMUST00000031862.3 ENSMUST00000031862.4 ENSMUST00000031862.5 ENSMUST00000031862.6 ENSMUST00000031862.7 ENSMUST00000031862.8 ENSMUST00000031862.9 NM_007624 Q9DCC5 Q9DCC5_MOUSE uc009bxr.1 uc009bxr.2 uc009bxr.3 chromosome, centromeric region chromatin nucleus nuclear euchromatin nuclear heterochromatin spindle cellular response to DNA damage stimulus enzyme binding protein domain specific binding identical protein binding negative regulation of transcription, DNA-templated histone methyltransferase binding uc009bxr.1 uc009bxr.2 uc009bxr.3 
ENSMUST00000031863.3 1700111E14Rik ENSMUST00000031863.3 1700111E14Rik (from geneSymbol) AK007169 ENSMUST00000031863.1 ENSMUST00000031863.2 uc291doc.1 uc291doc.2 uc291doc.1 uc291doc.2 
ENSMUST00000031866.9 Mtpn ENSMUST00000031866.9 myotrophin (from RefSeq NM_008098.4) ENSMUST00000031866.1 ENSMUST00000031866.2 ENSMUST00000031866.3 ENSMUST00000031866.4 ENSMUST00000031866.5 ENSMUST00000031866.6 ENSMUST00000031866.7 ENSMUST00000031866.8 Gcdp MTPN_MOUSE NM_008098 P62774 P80144 Q543M6 Q9DCN8 uc009bit.1 uc009bit.2 uc009bit.3 uc009bit.4 Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin- capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB. Cytoplasm Nucleus Cytoplasm, perinuclear region Belongs to the myotrophin family. nucleus cytoplasm cytosol catecholamine metabolic process F-actin capping protein complex regulation of cell size positive regulation of macromolecule biosynthetic process positive regulation of cardiac muscle hypertrophy cerebellar granule cell differentiation positive regulation of cell growth axon skeletal muscle tissue regeneration sequence-specific DNA binding perinuclear region of cytoplasm positive regulation of NF-kappaB transcription factor activity striated muscle cell differentiation positive regulation of protein metabolic process cellular response to mechanical stimulus regulation of barbed-end actin filament capping uc009bit.1 uc009bit.2 uc009bit.3 uc009bit.4 
ENSMUST00000031868.5 Slc13a4 ENSMUST00000031868.5 solute carrier family 13 (sodium/sulfate symporters), member 4 (from RefSeq NM_172892.3) ENSMUST00000031868.1 ENSMUST00000031868.2 ENSMUST00000031868.3 ENSMUST00000031868.4 NM_172892 Q8BZ82 Q8BZ82_MOUSE Slc13a4 uc009bip.1 uc009bip.2 uc009bip.3 uc009bip.4 Membrane ; Multi- pass membrane protein Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. dicarboxylic acid transport citrate transmembrane transporter activity succinate transmembrane transporter activity citrate transport membrane integral component of membrane sodium:dicarboxylate symporter activity transmembrane transporter activity transmembrane transport succinate transmembrane transport uc009bip.1 uc009bip.2 uc009bip.3 uc009bip.4 
ENSMUST00000031876.12 Stra8 ENSMUST00000031876.12 Meiosis-inducer required for the transition into meiosis for both female and male germ cells (PubMed:16461896, PubMed:17115059, PubMed:18799751, PubMed:18799790, PubMed:19805549, PubMed:32054698, PubMed:32032549). In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase (PubMed:16461896, PubMed:17115059, PubMed:18799751, PubMed:18799790, PubMed:32054698). During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation (PubMed:25902548). In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis (PubMed:19805549, PubMed:32032549). (from UniProt P70278) AK006887 ENSMUST00000031876.1 ENSMUST00000031876.10 ENSMUST00000031876.11 ENSMUST00000031876.2 ENSMUST00000031876.3 ENSMUST00000031876.4 ENSMUST00000031876.5 ENSMUST00000031876.6 ENSMUST00000031876.7 ENSMUST00000031876.8 ENSMUST00000031876.9 P70278 Q496Q5 STRA8_MOUSE Stra8 uc009bia.1 uc009bia.2 uc009bia.3 Meiosis-inducer required for the transition into meiosis for both female and male germ cells (PubMed:16461896, PubMed:17115059, PubMed:18799751, PubMed:18799790, PubMed:19805549, PubMed:32054698, PubMed:32032549). In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase (PubMed:16461896, PubMed:17115059, PubMed:18799751, PubMed:18799790, PubMed:32054698). During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation (PubMed:25902548). In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis (PubMed:19805549, PubMed:32032549). Interacts with XPO1. Interacts with MEIOSIN (PubMed:32032549). P70278; A2CG63: Arid4b; NbExp=4; IntAct=EBI-6394115, EBI-6394082; Cytoplasm cleus Note=Shuttles between nucleus and cytoplasm (PubMed:19805549). Nuclear export is XPO1-dependent (PubMed:19805549). Expressed exclusively in premeiotic germ cells in both sexes. In females, is expressed in the embryonic ovary. In males, is expressed in pubertal and adult testes, in premeiotic spermatogenic cells. Expressed by some type A and B spermatogonia, preleptotene spermatocytes, and early leptotene spermatocytes (at protein level). Expression begins in late undifferentiated spermatogonia and persists during differentiating spermatogonia (at protein level). Up-regulated in embryonic germ cells of the female gonads in an anterior-to-posterior wave from 12.5 dpc to 16.5 dpc. In male gonads, expression is first detected after birth. Up-regulated by retinoic acid in embryonic ovaries and adult testes, and by all-trans and 9-cis retinoic acid in P19 embryonic carcinoma (EC) cells. Transcription is repressed by DMRT1 in undifferentiated spermatogonia. Phosphorylated in P19 EC cells. Female and male mice are infertile due to severe gametogenesis impairment. In female mutant embryos, the initial mitotic development of germ cells is normal, but they fail to undergo promeiotic DNA replication and meiotic chromosome condensation. In male mutants, the premeiotic DNA replication is conserved and germ cells are able to partly condense chromosomes and initiate meiotic recombination. However, they fail to regularily continue over the leptotene stage of prophase I. protein binding nucleus cytoplasm DNA replication spermatogenesis cell differentiation positive regulation of transcription from RNA polymerase II promoter male germ-line stem cell asymmetric division oogenesis meiotic cell cycle cellular response to retinoic acid uc009bia.1 uc009bia.2 uc009bia.3 
ENSMUST00000031879.5 Tcaf2 ENSMUST00000031879.5 TRPM8 channel-associated factor 2 (from RefSeq NM_146174.1) ENSMUST00000031879.1 ENSMUST00000031879.2 ENSMUST00000031879.3 ENSMUST00000031879.4 Fam115c Fam139a NM_146174 Q6KAN8 Q921K8 Q922C4 TCAF2_MOUSE Tcaf2 uc009brn.1 uc009brn.2 uc009brn.3 Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8- dependent manner. Interacts with TRPM8 (via N-terminus and C-terminus domains); the interaction inhibits TRPM8 channel activity. Interacts with TRPV6. Cell membrane Note=Colocalizes with TRPM8 on the plasma membrane. Belongs to the TCAF family. Sequence=BAD21419.1; Type=Erroneous initiation; Evidence=; hematopoietic progenitor cell differentiation plasma membrane negative regulation of anion channel activity membrane cell junction positive regulation of cell migration ion channel binding positive regulation of protein targeting to membrane uc009brn.1 uc009brn.2 uc009brn.3 
ENSMUST00000031894.13 Clcn1 ENSMUST00000031894.13 chloride channel, voltage-sensitive 1, transcript variant 1 (from RefSeq NM_013491.4) CLCN1_MOUSE Clc1 ENSMUST00000031894.1 ENSMUST00000031894.10 ENSMUST00000031894.11 ENSMUST00000031894.12 ENSMUST00000031894.2 ENSMUST00000031894.3 ENSMUST00000031894.4 ENSMUST00000031894.5 ENSMUST00000031894.6 ENSMUST00000031894.7 ENSMUST00000031894.8 ENSMUST00000031894.9 NM_013491 Q64347 Q8BZ41 Q9QVY5 uc009bqs.1 uc009bqs.2 Voltage-gated chloride channel (By similarity). Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction (Probable) (PubMed:8119941). Reaction=2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in); Xref=Rhea:RHEA:29567, ChEBI:CHEBI:15378, ChEBI:CHEBI:17996; Evidence=; Homodimer. Cell membrane ; Multi-pass membrane protein Predominantly expressed in skeletal muscles. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 1/CLCN1 subfamily. voltage-gated ion channel activity voltage-gated chloride channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport muscle contraction membrane integral component of membrane neuronal action potential propagation chloride channel complex regulation of ion transmembrane transport sarcolemma protein homodimerization activity transmembrane transport chloride transmembrane transport uc009bqs.1 uc009bqs.2 
ENSMUST00000031895.13 Casp2 ENSMUST00000031895.13 caspase 2, transcript variant 7 (from RefSeq NR_176863.1) CASP2_MOUSE ENSMUST00000031895.1 ENSMUST00000031895.10 ENSMUST00000031895.11 ENSMUST00000031895.12 ENSMUST00000031895.2 ENSMUST00000031895.3 ENSMUST00000031895.4 ENSMUST00000031895.5 ENSMUST00000031895.6 ENSMUST00000031895.7 ENSMUST00000031895.8 ENSMUST00000031895.9 Ich1 NR_176863 Nedd-2 Nedd2 O08737 P29594 Q3TCM0 Q8C9H7 Q8K241 uc009bqq.1 uc009bqq.2 uc009bqq.3 Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:7958843). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (By similarity). Reaction=Strict requirement for an Asp residue at P1, with 316-Asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.; EC=3.4.22.55; Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Forms a complex named the PIDDosome with PIDD1 and CRADD. Interacts with NOL3 (via CARD domain); inhibits CASP2 activity in a phosphorylation- dependent manner. High level expression seen in the embryonic CNS, liver, lung, kidney, small intestine, and hair follicles of vibrissae. Moderate expression seen in the skin, oral mucosa, skeletal muscle, submandibular gland and thymus. In the adult, it is highly expressed in spleen, lung and kidney. Moderately in the brain, heart, testis, liver. Low levels in the thymus, skeletal muscle, ovary and gut. During embryonic development is highly expressed in several types of mouse tissue undergoing high rates of programmed cell death such as central nervous system and kidney. The CARD domain mediates a direct interaction with CRADD. The mature protease can process its own propeptide, but not that of other caspases. Belongs to the peptidase C14A family. luteolysis neural retina development cysteine-type endopeptidase activity protein binding nucleus cytoplasm mitochondrion proteolysis apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest brain development aging peptidase activity cysteine-type peptidase activity membrane protein processing hydrolase activity protein domain specific binding ectopic germ cell programmed cell death identical protein binding regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of neuron apoptotic process cellular response to mechanical stimulus cysteine-type endopeptidase activity involved in apoptotic process apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand execution phase of apoptosis cysteine-type endopeptidase activity involved in execution phase of apoptosis positive regulation of apoptotic signaling pathway uc009bqq.1 uc009bqq.2 uc009bqq.3 
ENSMUST00000031897.8 Gstk1 ENSMUST00000031897.8 glutathione S-transferase kappa 1 (from RefSeq NM_029555.2) ENSMUST00000031897.1 ENSMUST00000031897.2 ENSMUST00000031897.3 ENSMUST00000031897.4 ENSMUST00000031897.5 ENSMUST00000031897.6 ENSMUST00000031897.7 GSTK1_MOUSE NM_029555 Q9DCM2 uc009bqo.1 uc009bqo.2 Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Homodimer. Q9DCM2; Q60994: Adipoq; NbExp=3; IntAct=EBI-8369416, EBI-7264589; Mitochondrion Predominantly expressed in heart, kidney, liver and skeletal muscle. Acetylation of Lys-93 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the GST superfamily. Kappa family. glutathione transferase activity glutathione peroxidase activity protein binding mitochondrion mitochondrial inner membrane mitochondrial matrix peroxisome glutathione metabolic process protein disulfide oxidoreductase activity transferase activity epithelial cell differentiation oxidation-reduction process cellular oxidant detoxification uc009bqo.1 uc009bqo.2 
ENSMUST00000031898.5 Sval1 ENSMUST00000031898.5 seminal vesicle antigen-like 1 (from RefSeq NM_027832.3) ENSMUST00000031898.1 ENSMUST00000031898.2 ENSMUST00000031898.3 ENSMUST00000031898.4 NM_027832 Q9D2X6 Q9D2X6_MOUSE Sval1 mcsp uc009bqj.1 uc009bqj.2 uc009bqj.3 Monomer. Interacts with AZGP1. Belongs to the PIP family. regulation of immune system process aspartic-type endopeptidase activity extracellular region extracellular space proteolysis uc009bqj.1 uc009bqj.2 uc009bqj.3 
ENSMUST00000031899.14 Kel ENSMUST00000031899.14 Kell blood group (from RefSeq NM_032540.3) ENSMUST00000031899.1 ENSMUST00000031899.10 ENSMUST00000031899.11 ENSMUST00000031899.12 ENSMUST00000031899.13 ENSMUST00000031899.2 ENSMUST00000031899.3 ENSMUST00000031899.4 ENSMUST00000031899.5 ENSMUST00000031899.6 ENSMUST00000031899.7 ENSMUST00000031899.8 ENSMUST00000031899.9 KELL_MOUSE NM_032540 Q499D7 Q9EQF2 uc009bqf.1 uc009bqf.2 uc009bqf.3 uc009bqf.4 Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3 (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Heterodimer with XK; disulfide-linked. Cell membrane ; Single-pass type II membrane protein Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton. Highly expressed in spleen. Weaker expression in testis and heart. N-glycosylated. Belongs to the peptidase M13 family. endopeptidase activity metalloendopeptidase activity plasma membrane proteolysis cellular calcium ion homeostasis peptidase activity metallopeptidase activity regulation of cell size cellular magnesium ion homeostasis membrane integral component of membrane hydrolase activity regulation of axon diameter myelination metal ion binding skeletal muscle fiber development negative regulation of potassium ion transmembrane transport uc009bqf.1 uc009bqf.2 uc009bqf.3 uc009bqf.4 
ENSMUST00000031900.6 Llcfc1 ENSMUST00000031900.6 LLLL and CFNLAS motif containing 1, transcript variant 1 (from RefSeq NM_029671.2) ENSMUST00000031900.1 ENSMUST00000031900.2 ENSMUST00000031900.3 ENSMUST00000031900.4 ENSMUST00000031900.5 LCFC1_MOUSE Llcfc1 NM_029671 Q9D9P8 Sof1 uc009bqe.1 uc009bqe.2 Sperm protein required for fusion of sperm with the egg membrane during fertilization. Secreted Detected in testicular germ cells and spermatozoa (at protein level). Abundantly expressed in testis. Detected in the testis after postnatal day 28. Male infertility (PubMed:32393636). Sperm are morphologically normal, exhibit normal motility and can penetrate the zona pellucida but are unable to fuse with the egg membrane (PubMed:32393636). No effect on amount or localization of sperm-egg fusion protein IZUMO1 (PubMed:32393636). molecular_function cellular_component extracellular region biological_process uc009bqe.1 uc009bqe.2 
ENSMUST00000031901.11 Trpv5 ENSMUST00000031901.11 transient receptor potential cation channel, subfamily V, member 5 (from RefSeq NM_001007572.2) ENSMUST00000031901.1 ENSMUST00000031901.10 ENSMUST00000031901.2 ENSMUST00000031901.3 ENSMUST00000031901.4 ENSMUST00000031901.5 ENSMUST00000031901.6 ENSMUST00000031901.7 ENSMUST00000031901.8 ENSMUST00000031901.9 NM_001007572 P69744 Q2TB50 TRPV5_MOUSE uc009bqd.1 uc009bqd.2 uc009bqd.3 Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:12077127, PubMed:14679186). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (PubMed:14679186). The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (PubMed:12077127). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). Activated by WNK3. Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6 (PubMed:12574114). Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane (PubMed:12660155). Interacts with calmodulin (PubMed:15123711). Interacts with BSPRY, which results in its inactivation (PubMed:16380433). P69744; Q80UE6: Wnk4; NbExp=2; IntAct=EBI-538447, EBI-295378; Apical cell membrane ; Multi-pass membrane protein Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells. Detected in kidney cortex (at protein level). Glycosylated. Mutant mice appear grossly normal and are fertile. They display polyuria and increased urinary excretion of Ca(2+), due to defective Ca(2+) reabsorption in the kidney distal convoluted tubules. Likewise, they display increased urinary excretion of phosphate. Besides, their urine has a lower pH. The polyuria and the urine acidification may be a response to the high urinary Ca(2+) levels, preventing the formation of kidney stones (PubMed:14679186). Serum Ca(2+) and phosphate levels are normal, probably due to increased expression of TRPV6 and increased Ca(2+) absorption in the intestine. The increased expression of TRPV6 may be due to the increased serum levels of 1,25-dihydroxy-vitamin D3 that are observed in mutant mice (PubMed:14679186, PubMed:27102152). Age-related changes in trabecular and cortical bone mass are accelerated in male mutant mice, including reduced trabecular and cortical bone thickness. Still, this has no effect on bone strength (PubMed:27102152). Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily. Sequence=AK085479; Type=Frameshift; Evidence=; ion channel activity calcium channel activity protein binding calmodulin binding plasma membrane integral component of plasma membrane ion transport calcium ion transport cellular calcium ion homeostasis membrane integral component of membrane apical plasma membrane intrinsic component of plasma membrane regulation of urine volume metal ion binding protein tetramerization protein homotetramerization calcium ion homeostasis transmembrane transport calcium ion transport into cytosol calcium ion transmembrane transport calcium ion import across plasma membrane uc009bqd.1 uc009bqd.2 uc009bqd.3 
ENSMUST00000031902.7 Trpv6 ENSMUST00000031902.7 transient receptor potential cation channel, subfamily V, member 6 (from RefSeq NM_022413.4) ENSMUST00000031902.1 ENSMUST00000031902.2 ENSMUST00000031902.3 ENSMUST00000031902.4 ENSMUST00000031902.5 ENSMUST00000031902.6 NM_022413 Q91WD2 TRPV6_MOUSE uc009bqc.1 uc009bqc.2 uc009bqc.3 uc009bqc.4 uc009bqc.5 Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:12765696, PubMed:12601087, PubMed:12574114, PubMed:14736889, PubMed:15123711, PubMed:17129178). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (PubMed:17129178, PubMed:22878123). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)- dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation (PubMed:15123711). In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner (PubMed:12601087). Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114). Interacts with TCAF1 and TCAF2 (By similarity). Homotetramer and probably heterotetramer with TRPV5 (PubMed:12574114). Interacts with TRPV5 (PubMed:12574114). Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane (PubMed:12660155). Interacts with calmodulin (PubMed:12765696, PubMed:15123711). Interacts with BSPRY (PubMed:16380433). Cell membrane ulti-pass membrane protein Detected in intestine (at protein level) (PubMed:17129178). Abundantly expressed in pancreas and placenta, and to a much lesser extent in stomach and kidney (PubMed:12765696). Detected in kidney and duodenum (PubMed:17129178, PubMed:20399919). Up-regulated in intestine by exposure to a low-calcium diet (PubMed:17129178, PubMed:22878123). Down-regulated in intestine in response to a high-calcium diet (PubMed:17129178). Glycosylated. Phosphorylation at Tyr-201 and Tyr-202 by SRC leads to an increased calcium influx through the channel. Probably dephosphorylated at these sites by PTPN1 (By similarity). Mutant mice have lower body weight than their littermates throughout their lifespan and low fertility, due to impaired calcium homeostasis. Mutant mice display strongly impaired intestinal Ca(2+) uptake and increased urinary Ca(2+) levels (PubMed:17129178). Still, their serum Ca(2+) levels are normal, probably due to compensation by another calcium channel (PubMed:17129178, PubMed:20399919). In spite of this, mutant mice display decreased femoral mineral density; also when they are fed a high-calcium diet (PubMed:17129178). In contrast, no difference in bone density was observed in another study; mutant and wild-type mice displayed similar values when fed a normal diet, and a similar reduction in bone mass when fed a low-calcium diet (PubMed:20399919). Besides, the majority of mutant mice display alopecia and develop dermatitis (PubMed:17129178). Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily. Sequence=AAH16101.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ACG threonine codon.; Evidence=; Sequence=BAC36699.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ACG threonine codon.; Evidence=; ion channel activity calcium channel activity calmodulin binding plasma membrane integral component of plasma membrane ion transport calcium ion transport membrane integral component of membrane parathyroid hormone secretion identical protein binding metal ion binding protein homotetramerization response to calcium ion calcium ion homeostasis transmembrane transport calcium ion import calcium ion transmembrane transport calcium ion import across plasma membrane uc009bqc.1 uc009bqc.2 uc009bqc.3 uc009bqc.4 uc009bqc.5 
ENSMUST00000031910.8 Prss1 ENSMUST00000031910.8 serine protease 1 (trypsin 1) (from RefSeq NM_053243.2) ENSMUST00000031910.1 ENSMUST00000031910.2 ENSMUST00000031910.3 ENSMUST00000031910.4 ENSMUST00000031910.5 ENSMUST00000031910.6 ENSMUST00000031910.7 NM_053243 Prss1 Q9Z1R9 Q9Z1R9_MOUSE Trygn16 trypsinogen uc009boy.1 uc009boy.2 uc009boy.3 uc009boy.4 serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009boy.1 uc009boy.2 uc009boy.3 uc009boy.4 
ENSMUST00000031913.5 Try4 ENSMUST00000031913.5 trypsin 4 (from RefSeq NM_011646.5) ENSMUST00000031913.1 ENSMUST00000031913.2 ENSMUST00000031913.3 ENSMUST00000031913.4 NM_011646 Q9R0T7 T8 TRY4_MOUSE Td Try4 uc009bos.1 uc009bos.2 uc009bos.3 Serine protease capable of autoactivation. Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Activated by autocatalytic cleavage (PubMed:23814066). Cleavage by CTRC inhibits autoactivation (PubMed:23814066). Secreted, extracellular space Expressed in the pancreas, lung and kidney. Proteolytically cleaved and activated by an autocatalytic mechanism (PubMed:23814066). Cleavage by CTRC inhibits autoactivation (PubMed:23814066). Belongs to the peptidase S1 family. serine-type endopeptidase activity calcium ion binding extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009bos.1 uc009bos.2 uc009bos.3 
ENSMUST00000031914.6 Ccdc184 ENSMUST00000031914.6 coiled-coil domain containing 184 (from RefSeq NM_177716.3) CC184_MOUSE ENSMUST00000031914.1 ENSMUST00000031914.2 ENSMUST00000031914.3 ENSMUST00000031914.4 ENSMUST00000031914.5 NM_177716 Q4VBF4 Q8BMK5 Q8BV27 uc011zys.1 uc011zys.2 uc011zys.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BMK5-1; Sequence=Displayed; Name=2; IsoId=Q8BMK5-2; Sequence=VSP_033768; Sequence=AAH90621.2; Type=Erroneous initiation; Evidence=; Sequence=AAH95968.3; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm biological_process uc011zys.1 uc011zys.2 uc011zys.3 
ENSMUST00000031931.6 Prss3b ENSMUST00000031931.6 serine protease 3B (from RefSeq NM_023333.4) 2210010C04Rik ENSMUST00000031931.1 ENSMUST00000031931.2 ENSMUST00000031931.3 ENSMUST00000031931.4 ENSMUST00000031931.5 NM_023333 Prss3b Q9CPN9 Q9CPN9_MOUSE trypsinogen uc009bno.1 uc009bno.2 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009bno.1 uc009bno.2 
ENSMUST00000031935.10 Prss59 ENSMUST00000031935.10 serine protease 59, transcript variant 1 (from RefSeq NM_028550.4) 1700074P13Rik ENSMUST00000031935.1 ENSMUST00000031935.2 ENSMUST00000031935.3 ENSMUST00000031935.4 ENSMUST00000031935.5 ENSMUST00000031935.6 ENSMUST00000031935.7 ENSMUST00000031935.8 ENSMUST00000031935.9 NM_028550 Prss59 Q9D9G7 Q9D9G7_MOUSE uc009bnl.1 uc009bnl.2 serine-type endopeptidase activity Golgi apparatus proteolysis secretory granule uc009bnl.1 uc009bnl.2 
ENSMUST00000031937.4 Moxd2 ENSMUST00000031937.4 monooxygenase, DBH-like 2 (from RefSeq NM_139296.2) Dbhl Dbhl1 ENSMUST00000031937.1 ENSMUST00000031937.2 ENSMUST00000031937.3 MOXD2_MOUSE NM_139296 Q7TT41 Q91XT2 uc009bnh.1 uc009bnh.2 Name=Cu(2+); Xref=ChEBI:CHEBI:29036; Evidence=; Note=Binds 2 copper ions per subunit. ; Membrane ; Single-pass type I membrane protein Expressed at low levels in thymus and testis. Belongs to the copper type II ascorbate-dependent monooxygenase family. catalytic activity monooxygenase activity dopamine beta-monooxygenase activity copper ion binding extracellular space cytoplasm octopamine biosynthetic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen secretory granule membrane dopamine catabolic process norepinephrine biosynthetic process metal ion binding oxidation-reduction process uc009bnh.1 uc009bnh.2 
ENSMUST00000031967.6 Prss37 ENSMUST00000031967.6 serine protease 37, transcript variant 1 (from RefSeq NM_026317.3) ENSMUST00000031967.1 ENSMUST00000031967.2 ENSMUST00000031967.3 ENSMUST00000031967.4 ENSMUST00000031967.5 NM_026317 PRS37_MOUSE Prss37 Q9CUH3 Q9DAA4 Tryx2 uc009bmx.1 uc009bmx.2 Plays a role in male fertility (PubMed:23553430). May have a role in sperm migration or binding to zona-intact eggs (PubMed:23553430). Involved in the activation of the proacrosin/acrosin system (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome Secreted Testis-specific (PubMed:23553430). Expressed in spermatids (PubMed:23553430). Weakly expressed in mature sperm (at protein level) (PubMed:23553430). Expressed exclusively in the spermatids at steps 9-14 of spermiogenesis (PubMed:23553430). Mice exhibit male infertility, but their mating behavior, spermatogenesis, sperm morphology and motility remain unaffected (PubMed:23553430). Male sperm migration from uterus into oviduct and zona-intact oocyte binding are impaired; however, sperm is still able to fertilize cumulus-intact oocytes (PubMed:23553430). Male show an absence of mature ADAM3 in sperm (PubMed:23553430). Belongs to the peptidase S1 family. Although related to peptidase S1 family, lacks the conserved active Ser residue in position 192 which is replaced by an Ala, suggesting that it has no protease activity. Lacks also metal binding sites Glu in position 67 which is replaced by Asn and Asn in position 69 which is replaced by Lys. acrosomal vesicle serine-type endopeptidase activity extracellular region proteolysis single fertilization binding of sperm to zona pellucida cell migration secretory granule cytoplasmic vesicle metal ion binding protein maturation regulation of protein processing positive regulation of fertilization positive regulation of acrosome reaction uc009bmx.1 uc009bmx.2 
ENSMUST00000031976.14 Prdm5 ENSMUST00000031976.14 PR domain containing 5, transcript variant 1 (from RefSeq NM_027547.2) B2RSK8 ENSMUST00000031976.1 ENSMUST00000031976.10 ENSMUST00000031976.11 ENSMUST00000031976.12 ENSMUST00000031976.13 ENSMUST00000031976.2 ENSMUST00000031976.3 ENSMUST00000031976.4 ENSMUST00000031976.5 ENSMUST00000031976.6 ENSMUST00000031976.7 ENSMUST00000031976.8 ENSMUST00000031976.9 NM_027547 PRDM5_MOUSE Q9CXE0 uc009cek.1 uc009cek.2 uc009cek.3 Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes (By similarity). May regulate the expression of proteins involved in extracellular matrix development and maintenance, connective tissue components and molecules regulating cell migration and adhesion. May cause G2/M arrest and apoptosis in cancer cells (By similarity). Interacts with EHMT2/G9A, GFI1 and HDAC1. Nucleus Belongs to the class V-like SAM-binding methyltransferase superfamily. negative regulation of transcription from RNA polymerase II promoter mitotic cell cycle transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus nucleolus chromatin organization methyltransferase activity histone deacetylation nuclear body transferase activity methylation sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated metal ion binding histone H3-K9 methylation repressing transcription factor binding cellular response to leukemia inhibitory factor uc009cek.1 uc009cek.2 uc009cek.3 
ENSMUST00000031977.12 Agk ENSMUST00000031977.12 acylglycerol kinase (from RefSeq NM_023538.2) AGK_MOUSE Agk ENSMUST00000031977.1 ENSMUST00000031977.10 ENSMUST00000031977.11 ENSMUST00000031977.2 ENSMUST00000031977.3 ENSMUST00000031977.4 ENSMUST00000031977.5 ENSMUST00000031977.6 ENSMUST00000031977.7 ENSMUST00000031977.8 ENSMUST00000031977.9 Mulk NM_023538 Q9D087 Q9ESW4 uc009bmn.1 uc009bmn.2 uc009bmn.3 uc009bmn.4 Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15252046). Phosphorylates ceramide but not sphingosine (PubMed:15252046). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (PubMed:18004883). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (By similarity). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (By similarity). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (By similarity). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (By similarity). Reaction=a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3- phosphate; Xref=Rhea:RHEA:19293, ChEBI:CHEBI:15378, ChEBI:CHEBI:17408, ChEBI:CHEBI:30616, ChEBI:CHEBI:77589, ChEBI:CHEBI:456216; EC=2.7.1.94; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19294; Evidence=; Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10273; Evidence=; Reaction=an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+); Xref=Rhea:RHEA:17929, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52639, ChEBI:CHEBI:57674, ChEBI:CHEBI:456216; EC=2.7.1.138; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17930; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)- sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:41079, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:74544, ChEBI:CHEBI:75757, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41080; Evidence=; Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43328, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:34071, ChEBI:CHEBI:74938, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43329; Evidence=; Reaction=a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:33747, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57970, ChEBI:CHEBI:64683, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33748; Evidence=; Reaction=1-hexadecanoyl-sn-glycerol + ATP = 1-hexadecanoyl-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43308, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57518, ChEBI:CHEBI:75542, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43309; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43316, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52392, ChEBI:CHEBI:78209, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43317; Evidence=; Reaction=ATP + N-(hexanoyl)sphing-4-enine = ADP + H(+) + N- hexanoylsphing-4-enine 1-phosphate; Xref=Rhea:RHEA:43312, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:63867, ChEBI:CHEBI:82959, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43313; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Both the ceramide and diacylglycerol kinase activities are inhibited by sphingosine and stimulated by cardiolipin (PubMed:15252046). Both activities are stimulated by calcium when magnesium concentrations are low but inhibited by calcium when magnesium concentrations are high (PubMed:15252046). Kinetic parameters: KM=45 uM for diacylglycerol ; KM=34 uM for ceramide ; Vmax=159 nmol/min/mg enzyme with dioeoylglycerol as substrate ; Vmax=37 nmol/min/mg enzyme with ceramide as substrate ; Vmax=23.6 nmol/min/mg enzyme with 1,2-dioleoylglycerol as substrate ; Vmax=10.21 nmol/min/mg enzyme with 2,3-dioleoylglycerol as substrate ; Lipid metabolism; glycerolipid metabolism. Component of the TIM22 complex, which core is composed of TIMM22, associated with TIMM10 (TIMM10A and/or TIMM10B), TIMM9, AGK and TIMM29. Mitochondrion inner membrane ; Peripheral membrane protein Mitochondrion intermembrane space Note=Localizes in the mitochondrion intermembrane space, where it associates with the inner membrane. It is unclear whether the N-terminal hydrophobic region forms a transmembrane region or associates with the membrane without crossing it. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ESW4-1; Sequence=Displayed; Name=2; IsoId=Q9ESW4-2; Sequence=VSP_020927; Ubiquitously expressed. Belongs to the AGK family. Was originally (PubMed:15252046) thought to have ceramide kinase activity. Such activity is however unlikely in vivo. nucleotide binding lipid kinase activity ceramide kinase activity NAD+ kinase activity diacylglycerol kinase activity ATP binding mitochondrion mitochondrial inner membrane mitochondrial intermembrane space membrane kinase activity phosphorylation transferase activity integral component of mitochondrial inner membrane mitochondrial membrane mitochondrial inner membrane protein insertion complex intracellular membrane-bounded organelle protein import into mitochondrial inner membrane glycerolipid metabolic process ceramide biosynthetic process lipid phosphorylation acylglycerol kinase activity uc009bmn.1 uc009bmn.2 uc009bmn.3 uc009bmn.4 
ENSMUST00000031978.9 Mrps33 ENSMUST00000031978.9 mitochondrial ribosomal protein S33, transcript variant 1 (from RefSeq NM_010270.2) ENSMUST00000031978.1 ENSMUST00000031978.2 ENSMUST00000031978.3 ENSMUST00000031978.4 ENSMUST00000031978.5 ENSMUST00000031978.6 ENSMUST00000031978.7 ENSMUST00000031978.8 Gdap3 NM_010270 O88743 Q9D2R8 RT33_MOUSE uc009bmi.1 uc009bmi.2 uc009bmi.3 uc009bmi.4 uc009bmi.5 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mS33 family. Sequence=CAA76895.1; Type=Erroneous initiation; Evidence=; molecular_function mitochondrion mitochondrial small ribosomal subunit ribosome biological_process uc009bmi.1 uc009bmi.2 uc009bmi.3 uc009bmi.4 uc009bmi.5 
ENSMUST00000031982.5 Hpgds ENSMUST00000031982.5 hematopoietic prostaglandin D synthase, transcript variant 1 (from RefSeq NM_019455.5) ENSMUST00000031982.1 ENSMUST00000031982.2 ENSMUST00000031982.3 ENSMUST00000031982.4 Gsts HPGDS_MOUSE Hpgds NM_019455 Pgds Ptgds2 Q14AR4 Q8CA80 Q9JHF7 uc009cee.1 uc009cee.2 uc009cee.3 uc009cee.4 Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity. Reaction=prostaglandin H2 = prostaglandin D2; Xref=Rhea:RHEA:10600, ChEBI:CHEBI:57405, ChEBI:CHEBI:57406; EC=5.3.99.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10601; Evidence=; Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Reaction=2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2; Xref=Rhea:RHEA:51232, ChEBI:CHEBI:85166, ChEBI:CHEBI:133979; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51233; Evidence=; Name=glutathione; Xref=ChEBI:CHEBI:57925; Evidence=; Note=Glutathione is required for the prostaglandin D synthase activity. ; Homodimer. Cytoplasm. Expressed in skin and oviduct. Belongs to the GST superfamily. Sigma family. magnesium ion binding prostaglandin biosynthetic process glutathione transferase activity prostaglandin-D synthase activity calcium ion binding cytoplasm lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process glutathione metabolic process transferase activity isomerase activity protein homodimerization activity negative regulation of male germ cell proliferation uc009cee.1 uc009cee.2 uc009cee.3 uc009cee.4 
ENSMUST00000031984.9 Smarcad1 ENSMUST00000031984.9 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1, transcript variant 1 (from RefSeq NM_007958.3) ENSMUST00000031984.1 ENSMUST00000031984.2 ENSMUST00000031984.3 ENSMUST00000031984.4 ENSMUST00000031984.5 ENSMUST00000031984.6 ENSMUST00000031984.7 ENSMUST00000031984.8 Etl1 Kiaa1122 NM_007958 Q04692 Q3UGK6 Q3UYR6 SMRCD_MOUSE uc009ced.1 uc009ced.2 uc009ced.3 DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double- strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Binds to DNA preferentially in the vicinity of transcriptional start sites. Interacts with MSH2 and TRIM28. Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Interacts with PCNA (By similarity). Nucleus romosome Note=Colocalizes with PCNA at replication forks during S phase. Recruited to double-strand breaks (DSBs) sites of DNA damage (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q04692-1; Sequence=Displayed; Name=2; IsoId=Q04692-2; Sequence=VSP_007080; Detected at low levels in fertilized and unfertilized eggs. Levels increased in two-cell embryos, decreased up to morula stage and were highest in blastocysts. Highly expressed in the inner cell mass of 3.5 day old blastocysts. Highly expressed in ectoderm and visceral endoderm at day 5.5. Detected throughout the brain and spinal cord at day 10 to 15. Detected in the basal layer of the epidermis after day 12.5, in particular on snout and distal on fore- and hindlimbs. Deficient mice have reduced viability and show growth retardation, skeletal dysplasia and impaired fertility. Belongs to the SNF2/RAD54 helicase family. Sequence=BAC65736.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAA49560.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; regulation of DNA recombination nucleotide binding DNA double-strand break processing heterochromatin DNA binding DNA helicase activity chromatin binding helicase activity ATP binding nucleus nucleoplasm chromosome DNA repair chromatin organization cellular response to DNA damage stimulus DNA-dependent ATPase activity hydrolase activity DNA duplex unwinding site of double-strand break ATP-dependent chromatin remodeling nuclear replication fork chromosome separation histone H3 deacetylation histone H4 deacetylation uc009ced.1 uc009ced.2 uc009ced.3 
ENSMUST00000031986.5 Rab19 ENSMUST00000031986.5 RAB19, member RAS oncogene family (from RefSeq NM_011226.2) ENSMUST00000031986.1 ENSMUST00000031986.2 ENSMUST00000031986.3 ENSMUST00000031986.4 NM_011226 O35697 P35294 Q6GTV2 RAB19_MOUSE uc009blp.1 uc009blp.2 uc009blp.3 uc009blp.4 Cell membrane ; Lipid-anchor ; Cytoplasmic side Expressed in a tissue-specific manner. Detected at high levels in intestine, lung and spleen, and at a lower level in kidney. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity GTP binding plasma membrane intracellular protein transport membrane Rab protein signal transduction uc009blp.1 uc009blp.2 uc009blp.3 uc009blp.4 
ENSMUST00000032065.15 Pcyox1 ENSMUST00000032065.15 prenylcysteine oxidase 1, transcript variant 1 (from RefSeq NM_025823.4) ENSMUST00000032065.1 ENSMUST00000032065.10 ENSMUST00000032065.11 ENSMUST00000032065.12 ENSMUST00000032065.13 ENSMUST00000032065.14 ENSMUST00000032065.2 ENSMUST00000032065.3 ENSMUST00000032065.4 ENSMUST00000032065.5 ENSMUST00000032065.6 ENSMUST00000032065.7 ENSMUST00000032065.8 ENSMUST00000032065.9 Kiaa0908 NM_025823 PCYOX_MOUSE Pcly Pcyox1 Q3UHV6 Q69ZW0 Q8BZX1 Q9CQF9 uc009cro.1 uc009cro.2 uc009cro.3 uc009cro.4 Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (PubMed:12151402). Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (PubMed:12151402). Reaction=an S-prenyl-L-cysteine + H2O + O2 = a prenal + H2O2 + L- cysteine; Xref=Rhea:RHEA:53892, Rhea:RHEA-COMP:13675, Rhea:RHEA- COMP:13676, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:35235, ChEBI:CHEBI:137934, ChEBI:CHEBI:137935; EC=1.8.3.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53893; Evidence=; Reaction=H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine = (2E,6E)-farnesal + H2O2 + L-cysteine; Xref=Rhea:RHEA:30231, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:15894, ChEBI:CHEBI:16240, ChEBI:CHEBI:35235, ChEBI:CHEBI:62141; EC=1.8.3.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30232; Evidence=; Reaction=[(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2 = (2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine; Xref=Rhea:RHEA:70407, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:35235, ChEBI:CHEBI:189549, ChEBI:CHEBI:189554; EC=1.8.3.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70408; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Lysosome Highly expressed in the liver, kidney, heart and brain. Mice are healthy and fertile, but show an accumulation of prenylcysteines within cells (PubMed:12151402). Significant accumulation of both farnesylcysteine and geranylgeranylcysteine in the brain and liver (PubMed:12151402). Belongs to the prenylcysteine oxidase family. prenylcysteine oxidase activity lysosome plasma membrane chloride transport chloride-transporting ATPase activity oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor prenylated protein catabolic process prenylcysteine catabolic process very-low-density lipoprotein particle oxidation-reduction process chloride transmembrane transport uc009cro.1 uc009cro.2 uc009cro.3 uc009cro.4 
ENSMUST00000032066.13 Tgfa ENSMUST00000032066.13 transforming growth factor alpha, transcript variant 1 (from RefSeq NM_031199.5) ENSMUST00000032066.1 ENSMUST00000032066.10 ENSMUST00000032066.11 ENSMUST00000032066.12 ENSMUST00000032066.2 ENSMUST00000032066.3 ENSMUST00000032066.4 ENSMUST00000032066.5 ENSMUST00000032066.6 ENSMUST00000032066.7 ENSMUST00000032066.8 ENSMUST00000032066.9 NM_031199 Q545E4 Q545E4_MOUSE Tgfa uc009crk.1 uc009crk.2 uc009crk.3 uc009crk.4 uc009crk.5 This gene encodes a member of the epidermal growth factor (EGF) family of proteins that regulate cellular proliferation. The encoded protein undergoes proteolytic processing to generate a soluble glycoprotein that is secreted by the cell. The secreted protein binds to the EGF receptors to initiate signaling events resulting in cellular proliferation, mucous production or inhibition of gastric acid secretion. The transgenic expression of the encoded protein in mice induces the development of cancers in various tissues such as liver, pancreas, skin and mammary glands. Mice lacking the encoded protein exhibit a wavy coat and curly whiskers phenotype as well as abnormalities in the eye. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK162680.1, U65016.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Lacks conserved residue(s) required for the propagation of feature annotation. epidermal growth factor receptor binding extracellular space nucleus plasma membrane positive regulation of cell proliferation membrane integral component of membrane wound healing response to drug negative regulation of apoptotic process negative regulation of cellular process hepatocyte proliferation uc009crk.1 uc009crk.2 uc009crk.3 uc009crk.4 uc009crk.5 
ENSMUST00000032070.4 Figla ENSMUST00000032070.4 folliculogenesis specific basic helix-loop-helix (from RefSeq NM_012013.2) ENSMUST00000032070.1 ENSMUST00000032070.2 ENSMUST00000032070.3 FIGLA_MOUSE NM_012013 O55208 uc009crb.1 uc009crb.2 Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. Heterodimer with TCF3/isoform E12. Nucleus Expressed only in the oocytes within the ovary and at lower level in the testis. Found in the resting oocytes of the primordial follicle cells, at the periphery of the ovary and in the hilar region. Also detected in growing oocytes, but at lower levels. Detected as early as embryonic day 13, shortly after the onset of sexual dimorphism of the gonads. Dramatically increases at the end of the embryonic development and peaks at 2 dpp, a time in ovarian development at which oocytes have become enclosed in primordial follicles. Decreases markedly by 7 and 14 days after birth. Persists, but at low level, in adult females. Not detected in male embryos, but detected in adult testes. Females display a defect in the formation of primordial follicles leading to infertility. Although embryonic gonadogenesis appeared normal, primordial follicles were not formed at birth, and massive depletion of oocytes resulted in shrunken ovaries and female sterility. Null females do not express ZP1, ZP2 or ZP3. Since its expression is oocyte-specific in females, Figla is a plausible candidate gene for primary ovarian failure in otherwise phenotypically normal women. The gene for Figla null males have normal fertility. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus transcription factor complex multicellular organism development transcription factor binding cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter protein dimerization activity oogenesis uc009crb.1 uc009crb.2 
ENSMUST00000032071.13 Dusp11 ENSMUST00000032071.13 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) (from RefSeq NM_028099.4) DUS11_MOUSE ENSMUST00000032071.1 ENSMUST00000032071.10 ENSMUST00000032071.11 ENSMUST00000032071.12 ENSMUST00000032071.2 ENSMUST00000032071.3 ENSMUST00000032071.4 ENSMUST00000032071.5 ENSMUST00000032071.6 ENSMUST00000032071.7 ENSMUST00000032071.8 ENSMUST00000032071.9 NM_028099 Pir1 Q6NXK5 Q8BTR4 Q8BYE4 uc009cqp.1 uc009cqp.2 uc009cqp.3 Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism. Monomer. May interact with SFRS7 and SFRS9/SRP30C. Nucleus Nucleus speckle Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. fibrillar center RNA binding polynucleotide 5'-phosphatase activity protein tyrosine phosphatase activity nucleus protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity RNA metabolic process dephosphorylation nuclear speck hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation intercellular bridge polynucleotide 5' dephosphorylation nucleotide phosphatase activity, acting on free nucleotides uc009cqp.1 uc009cqp.2 uc009cqp.3 
ENSMUST00000032073.7 Nat8 ENSMUST00000032073.7 N-acetyltransferase 8 (GCN5-related), transcript variant 2 (from RefSeq NM_023455.4) Cml4 ENSMUST00000032073.1 ENSMUST00000032073.2 ENSMUST00000032073.3 ENSMUST00000032073.4 ENSMUST00000032073.5 ENSMUST00000032073.6 NAT8_MOUSE NM_023455 Q9JIY7 uc009cqh.1 uc009cqh.2 uc009cqh.3 uc009cqh.4 Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6- acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (By similarity). Reaction=acetyl-CoA + an S-substituted L-cysteine = an N-acetyl-L- cysteine-S-conjugate + CoA + H(+); Xref=Rhea:RHEA:19213, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58717, ChEBI:CHEBI:58718; EC=2.3.1.80; Sulfur metabolism; glutathione metabolism. Interacts with PROM1. Interacts with BACE1 (By similarity). Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type II membrane protein Endoplasmic reticulum membrane ; Single-pass type II membrane protein Expressed in brain (at protein level). Belongs to the camello family. gastrulation with mouth forming second lysine N-acetyltransferase activity, acting on acetyl phosphate as donor endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus glutathione metabolic process negative regulation of cell adhesion N-acetyltransferase activity positive regulation of gene expression membrane integral component of membrane transferase activity transferase activity, transferring acyl groups peptidyl-lysine N6-acetylation endoplasmic reticulum-Golgi intermediate compartment membrane negative regulation of apoptotic process cysteine-S-conjugate N-acetyltransferase activity beta-amyloid metabolic process late recombination nodule uc009cqh.1 uc009cqh.2 uc009cqh.3 uc009cqh.4 
ENSMUST00000032074.5 Nat8f5 ENSMUST00000032074.5 N-acetyltransferase 8 (GCN5-related) family member 5 (from RefSeq NM_023493.2) CMLO5_MOUSE Cml5 ENSMUST00000032074.1 ENSMUST00000032074.2 ENSMUST00000032074.3 ENSMUST00000032074.4 NM_023493 Q8R1G0 Q9D8Z0 Q9QXS8 uc009cqg.1 uc009cqg.2 uc009cqg.3 May play a role in regulation of gastrulation. Membrane ; Multi-pass membrane protein Belongs to the camello family. gastrulation with mouth forming second endoplasmic reticulum Golgi apparatus negative regulation of cell adhesion multicellular organism development determination of left/right symmetry gastrulation heart development N-acetyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring acyl groups extracellular space uc009cqg.1 uc009cqg.2 uc009cqg.3 
ENSMUST00000032078.9 Cct7 ENSMUST00000032078.9 chaperonin containing TCP1 subunit 7 (from RefSeq NM_007638.4) Cct7 ENSMUST00000032078.1 ENSMUST00000032078.2 ENSMUST00000032078.3 ENSMUST00000032078.4 ENSMUST00000032078.5 ENSMUST00000032078.6 ENSMUST00000032078.7 ENSMUST00000032078.8 NM_007638 Q3TIJ7 Q3TIJ7_MOUSE uc009cpv.1 uc009cpv.2 uc009cpv.3 uc009cpv.4 Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Cytoplasm Belongs to the TCP-1 chaperonin family. nucleotide binding ATP binding cytoplasm chaperonin-containing T-complex microtubule protein folding positive regulation of telomere maintenance via telomerase protein stabilization unfolded protein binding positive regulation of establishment of protein localization to telomere uc009cpv.1 uc009cpv.2 uc009cpv.3 uc009cpv.4 
ENSMUST00000032080.9 Pradc1 ENSMUST00000032080.9 protease-associated domain containing 1, transcript variant 2 (from RefSeq NM_001163427.1) ENSMUST00000032080.1 ENSMUST00000032080.2 ENSMUST00000032080.3 ENSMUST00000032080.4 ENSMUST00000032080.5 ENSMUST00000032080.6 ENSMUST00000032080.7 ENSMUST00000032080.8 NM_001163427 PADC1_MOUSE Pap21 Pradc1 Q9D9N8 uc009cps.1 uc009cps.2 uc009cps.3 uc009cps.4 Plays a role in the modulation of physical activity and adiposity. Secreted Expressed in metabolically active tissues such as liver, muscle, adipose, and heart and different brain regions like cortex and hypothalamus, expression is acutely regulated by the nutritional state. Expression in metabolically active tissues is significantly suppressed by refeeding. N-glycosylated; required for efficient secretion. Mutants born at the expected Mendelian ratio, and they appear normal with no gross developmental abnormalities (PubMed:31689374). Knockout female mice fed with high fat diet have reduced weight gain by elevating physical activity and energy expenditure (PubMed:31689374). molecular_function extracellular region biological_process uc009cps.1 uc009cps.2 uc009cps.3 uc009cps.4 
ENSMUST00000032089.3 Reg3g ENSMUST00000032089.3 regenerating islet-derived 3 gamma (from RefSeq NM_011260.2) ENSMUST00000032089.1 ENSMUST00000032089.2 NM_011260 Q545I1 Q545I1_MOUSE Reg3g uc009ckb.1 uc009ckb.2 uc009ckb.3 This gene encodes a C-type lectin that demonstrates bactericidal activity. This gene is predominantly expressed in the distal small intestine where the encoded protein undergoes proteolytic processing by trypsin. Mice lacking the encoded protein exhibit altered mucus distribution, increased bacterial contact with the epithelium, and elevated inflammatory markers in the ileum, and low-grade inflammation. [provided by RefSeq, Jun 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061139.1, AK008446.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## uc009ckb.1 uc009ckb.2 uc009ckb.3 
ENSMUST00000032093.12 Prickle2 ENSMUST00000032093.12 prickle planar cell polarity protein 2, transcript variant 5 (from RefSeq NM_001404086.1) A7YQ68 A7YQ68_MOUSE ENSMUST00000032093.1 ENSMUST00000032093.10 ENSMUST00000032093.11 ENSMUST00000032093.2 ENSMUST00000032093.3 ENSMUST00000032093.4 ENSMUST00000032093.5 ENSMUST00000032093.6 ENSMUST00000032093.7 ENSMUST00000032093.8 ENSMUST00000032093.9 NM_001404086 Prickle2 uc009cza.1 uc009cza.2 uc009cza.3 uc009cza.4 Belongs to the prickle / espinas / testin family. cytoplasm zinc ion binding metal ion binding uc009cza.1 uc009cza.2 uc009cza.3 uc009cza.4 
ENSMUST00000032094.7 Fbxl14 ENSMUST00000032094.7 F-box and leucine-rich repeat protein 14 (from RefSeq NM_133940.3) ENSMUST00000032094.1 ENSMUST00000032094.2 ENSMUST00000032094.3 ENSMUST00000032094.4 ENSMUST00000032094.5 ENSMUST00000032094.6 FXL14_MOUSE Fbl14 NM_133940 Ppa Q3U2Q9 Q8BID8 Q8R5H7 Q8VDT7 Q922N5 uc009dmj.1 uc009dmj.2 uc009dmj.3 uc009dmj.4 Substrate-recognition component of some (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity). Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase complex. Interacts with SKP1 and CUL1. Interacts with SNAI1; the interaction requires the phosphorylation of the two serine residues in the substrate destruction motif D-S-G-X(2,3,4)-S (By similarity). Cytoplasm ubiquitin-protein transferase activity cytoplasm ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process uc009dmj.1 uc009dmj.2 uc009dmj.3 uc009dmj.4 
ENSMUST00000032105.11 Lrig1 ENSMUST00000032105.11 Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. (from UniProt P70193) D78572 E9QL89 ENSMUST00000032105.1 ENSMUST00000032105.10 ENSMUST00000032105.2 ENSMUST00000032105.3 ENSMUST00000032105.4 ENSMUST00000032105.5 ENSMUST00000032105.6 ENSMUST00000032105.7 ENSMUST00000032105.8 ENSMUST00000032105.9 LRIG1_MOUSE P70193 uc291hgv.1 uc291hgv.2 Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. Interacts (via extracellular LRR and Ig-like domains) with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 (via extracellular domain). The physiological relevance of the interaction is controversial; LRIG1 may have low affinity for EGFR, and interaction may occur only when high levels of both proteins are present. Cell membrane ; Single-pass type I membrane protein Detected in brain (at protein level) (PubMed:12067728). Predominantly expressed in the brain, restricted to a small subset of glial cells, such as Bergmann glial cells of the cerebellum and glial cells in the nerve fiber layer of the olfactory bulb. Expressed also in the skin. Low expression is detected in the thymus and heart. No expression in the kidney, liver, lung or small intestine. Contains LRR and Ig-domains that can mediate low-affinity interaction with EGFR. The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when both the LRRs and the Ig-domains are deleted. Mutant mice are born at the expected Mendelian rate and initially display no visible phenotype. One to four months after birth, they develop skin abnormalities including alopecia and epidermal hyperplasia that are reminiscent of psoriasis. extracellular space plasma membrane sensory perception of sound membrane integral component of membrane hair cycle process extracellular matrix otolith morphogenesis innervation uc291hgv.1 uc291hgv.2 
ENSMUST00000032106.6 1700003E16Rik ENSMUST00000032106.6 RIKEN cDNA 1700003E16 gene (from RefSeq NM_027948.1) A0JNU0 CB081_MOUSE ENSMUST00000032106.1 ENSMUST00000032106.2 ENSMUST00000032106.3 ENSMUST00000032106.4 ENSMUST00000032106.5 NM_027948 Q9DAQ4 uc012enw.1 uc012enw.2 uc012enw.3 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DAQ4-1; Sequence=Displayed; Name=2; IsoId=Q9DAQ4-2; Sequence=VSP_032776; Name=3; IsoId=Q9DAQ4-3; Sequence=VSP_032777; molecular_function cellular_component biological_process uc012enw.1 uc012enw.2 uc012enw.3 
ENSMUST00000032107.10 Kbtbd8 ENSMUST00000032107.10 kelch repeat and BTB (POZ) domain containing 8, transcript variant 1 (from RefSeq NM_001008785.5) ENSMUST00000032107.1 ENSMUST00000032107.2 ENSMUST00000032107.3 ENSMUST00000032107.4 ENSMUST00000032107.5 ENSMUST00000032107.6 ENSMUST00000032107.7 ENSMUST00000032107.8 ENSMUST00000032107.9 KBTB8_MOUSE Kiaa1842 NM_001008785 Q3TJB2 Q3UQV5 Q5M7B2 Q8CH97 uc009czw.1 uc009czw.2 uc009czw.3 uc009czw.4 uc009czw.5 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Component of the BCR(KBTBD8) E3 ubiquitin ligase complex, at least composed of CUL3, KBTBD8 and RBX1. Cytoplasm, cytoskeleton, spindle Golgi apparatus Note=Translocates to the spindle apparatus during mitosis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UQV5-1; Sequence=Displayed; Name=2; IsoId=Q3UQV5-2; Sequence=VSP_023186; Down-regulated in differentiating embryonic stem cells (ESCs). Belongs to the KBTBD8 family. Sequence=AAH88734.1; Type=Erroneous initiation; Evidence=; cytoplasm Golgi apparatus spindle cytoskeleton regulation of translation protein monoubiquitination neural crest formation neural crest cell development Cul3-RING ubiquitin ligase complex uc009czw.1 uc009czw.2 uc009czw.3 uc009czw.4 uc009czw.5 
ENSMUST00000032114.8 Mogs ENSMUST00000032114.8 mannosyl-oligosaccharide glucosidase (from RefSeq NM_020619.3) ENSMUST00000032114.1 ENSMUST00000032114.2 ENSMUST00000032114.3 ENSMUST00000032114.4 ENSMUST00000032114.5 ENSMUST00000032114.6 ENSMUST00000032114.7 Gcs1 MOGS_MOUSE Mogs NM_020619 Q80UM7 Q9Z2W5 uc009cmn.1 uc009cmn.2 uc009cmn.3 In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner. (Microbial infection) Required for successful influenza or dengue virus infection; inhibition of its activity by a deoxynojirimycin derivative prevents death in mice infected with lethal doses of influenza or dengue viruses, even when administrated after infection. Reaction=H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc- (1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)- [alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D- Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc- (1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha- D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man- (1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]- beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl- [protein]; Xref=Rhea:RHEA:55988, Rhea:RHEA-COMP:12806, Rhea:RHEA- COMP:14355, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903, ChEBI:CHEBI:59082, ChEBI:CHEBI:132537; EC=3.2.1.106; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55989; Evidence=; Inhibited by the deoxynojirimycin derivative N-9'- Methoxynonyl-1-Deoxynojirimycin. Glycan metabolism; N-glycan degradation. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Belongs to the glycosyl hydrolase 63 family. catalytic activity mannosyl-oligosaccharide glucosidase activity endoplasmic reticulum endoplasmic reticulum membrane protein N-linked glycosylation metabolic process oligosaccharide metabolic process membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds uc009cmn.1 uc009cmn.2 uc009cmn.3 
ENSMUST00000032122.11 Tacr1 ENSMUST00000032122.11 tachykinin receptor 1 (from RefSeq NM_009313.5) ENSMUST00000032122.1 ENSMUST00000032122.10 ENSMUST00000032122.2 ENSMUST00000032122.3 ENSMUST00000032122.4 ENSMUST00000032122.5 ENSMUST00000032122.6 ENSMUST00000032122.7 ENSMUST00000032122.8 ENSMUST00000032122.9 NK1R_MOUSE NM_009313 P30548 Q8BYR7 Tac1r uc009clh.1 uc009clh.2 uc009clh.3 uc009clh.4 This gene encodes the receptor for the tachykinin, substance P, also referred to as neurokinin 1. This gene belongs to a gene family of tachykinin receptors which are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This receptor has been associated with nitric oxide formation, and it has been localized to cholinergic and nitrergic neurons as well as on smooth muscle cells. [provided by RefSeq, Mar 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC075631.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164141 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin K. Interacts with ARRB1. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. aggressive behavior positive regulation of leukocyte migration angiotensin-mediated drinking behavior G-protein coupled receptor activity tachykinin receptor activity cytoplasm plasma membrane signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration tachykinin receptor signaling pathway learning or memory long-term memory regulation of blood pressure associative learning response to heat response to hormone cell surface response to ozone positive regulation of epithelial cell migration response to auditory stimulus response to organic cyclic compound regulation of smooth muscle cell migration membrane integral component of membrane substance P receptor activity sensory perception of pain dendrite positive regulation of synaptic transmission, cholinergic positive regulation of synaptic transmission, GABAergic response to nicotine operant conditioning positive regulation of renal sodium excretion sperm flagellum sperm ejaculation eating behavior positive regulation of vascular permeability cell body response to ethanol positive regulation of action potential positive regulation of blood pressure positive regulation of ossification positive regulation of vasoconstriction positive regulation of saliva secretion positive regulation of hormone secretion response to pain behavioral response to pain regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation positive regulation of epithelial cell proliferation positive regulation of stress fiber assembly smooth muscle contraction involved in micturition regulation of uterine smooth muscle contraction positive regulation of uterine smooth muscle contraction cell periphery sperm midpiece positive regulation of flagellated sperm motility uc009clh.1 uc009clh.2 uc009clh.3 uc009clh.4 
ENSMUST00000032124.9 Mrpl19 ENSMUST00000032124.9 mitochondrial ribosomal protein L19 (from RefSeq NM_026490.2) ENSMUST00000032124.1 ENSMUST00000032124.2 ENSMUST00000032124.3 ENSMUST00000032124.4 ENSMUST00000032124.5 ENSMUST00000032124.6 ENSMUST00000032124.7 ENSMUST00000032124.8 NM_026490 Q543I0 Q8R1R0 Q9D338 RM19_MOUSE uc009clf.1 uc009clf.2 uc009clf.3 uc009clf.4 uc009clf.5 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the bacterial ribosomal protein bL19 family. structural constituent of ribosome nucleus mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit ribosome translation nuclear membrane uc009clf.1 uc009clf.2 uc009clf.3 uc009clf.4 uc009clf.5 
ENSMUST00000032125.7 Bmp10 ENSMUST00000032125.7 bone morphogenetic protein 10 (from RefSeq NM_009756.3) A6H6S5 BMP10_MOUSE ENSMUST00000032125.1 ENSMUST00000032125.2 ENSMUST00000032125.3 ENSMUST00000032125.4 ENSMUST00000032125.5 ENSMUST00000032125.6 NM_009756 Q9R229 Q9Z1V8 uc012eol.1 uc012eol.2 uc012eol.3 uc012eol.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. Homozygous knockout mice for this gene exhibit impaired heart development and embryonic lethality. [provided by RefSeq, Aug 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines (By similarity). Homodimer; disulfide-linked (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (By similarity). Interacts with ENG (PubMed:21737454). Secreted In the embryo, expressed exclusively in the ventricular trabecular myocardium of the developing heart from 9.0 dpc- 13.5 dpc. By 16.5 dpc-18.5 dpc, only detectable in atria. Highly expressed in the adult heart where it is found in the right atrium but not in the left atrium. Lower levels in adult liver and lung. Down-regulation after 14.5 dpc is critical for cardiomyocytes to undergo normal developmental hypertrophic growth in early postnatal life. Mice die in utero between 9.5 dpc and 10.5 dpc. They appear normal at 8.5 dpc-8.75 dpc but display cardiac dysgenesis at 9.0 dpc-9.5 dpc with profound hypoplastic ventricular walls and absence of ventricular trabeculae and have a significantly lower heart rate than wild type embryos. Mutants show up-regulation of Cdkn1c/p57KIP throughout the ventricular wall while levels of Mef2c and Nkx2-5 are normal at 8.5 dpc-8.75 dpc but are down-regulated at 9.25 dpc-9.5 dpc. Belongs to the TGF-beta family. cytokine activity transforming growth factor beta receptor binding hormone activity extracellular region extracellular space cytoplasm cell adhesion multicellular organism development heart development adult heart development growth factor activity cell surface negative regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy negative regulation of cardiac muscle hypertrophy positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation Z disc negative regulation of cell growth negative regulation of cell migration BMP signaling pathway telethonin binding activin receptor signaling pathway receptor serine/threonine kinase binding regulation of apoptotic process regulation of MAPK cascade sarcomere organization positive regulation of transcription, DNA-templated cell development atrial cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle cell development regulation of cardiac muscle contraction cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation positive regulation of sarcomere organization heart trabecula formation pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction positive regulation of cartilage development regulation of cardiac muscle hypertrophy in response to stress positive regulation of cell proliferation involved in heart morphogenesis uc012eol.1 uc012eol.2 uc012eol.3 uc012eol.4 
ENSMUST00000032127.6 Gkn3 ENSMUST00000032127.6 gastrokine 3 (from RefSeq NM_026860.1) ENSMUST00000032127.1 ENSMUST00000032127.2 ENSMUST00000032127.3 ENSMUST00000032127.4 ENSMUST00000032127.5 GKN3_MOUSE NM_026860 Q9D0T7 uc009ctj.1 uc009ctj.2 uc009ctj.3 Inhibits gastric epithelial cell proliferation. Secreted Expressed in stomach. Present in mucus cells at the base of antral glands, and Brunner glands of the duodenum. Present at lower levels in the mucus neck cell region of the fundus (at protein level). Belongs to the gastrokine family. molecular_function extracellular region extracellular space negative regulation of epithelial cell proliferation uc009ctj.1 uc009ctj.2 uc009ctj.3 
ENSMUST00000032128.6 Gkn2 ENSMUST00000032128.6 gastrokine 2 (from RefSeq NM_025467.1) Blot ENSMUST00000032128.1 ENSMUST00000032128.2 ENSMUST00000032128.3 ENSMUST00000032128.4 ENSMUST00000032128.5 GKN2_MOUSE NM_025467 Q9CQS6 uc009cti.1 uc009cti.2 uc009cti.3 Heterodimer with TFF1; disulfide linked (By similarity). Interacts with TFF2. Secreted Golgi apparatus Note=Secreted into the mucus layer, also present in Golgi apparatus and mucus granules. Stomach foveolar epithelium and duodenal Brunner's glands. Expressed from 17.5 dpc onwards. molecular_function extracellular region extracellular space Golgi apparatus response to bacterium basal part of cell uc009cti.1 uc009cti.2 uc009cti.3 
ENSMUST00000032129.3 Gkn1 ENSMUST00000032129.3 gastrokine 1 (from RefSeq NM_025466.1) Amp18 Ca11 ENSMUST00000032129.1 ENSMUST00000032129.2 GKN1_MOUSE NM_025466 Q9CR36 Q9CTZ5 Q9D7K7 uc009cth.1 uc009cth.2 uc009cth.3 Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. Secreted Cytoplasmic granule Golgi apparatus Note=Shows abundant granular cytoplasmic staining, with perinuclear accentuation suggestive of the Golgi apparatus. Expressed in the stomach (PubMed:15221938). Highly expressed specifically in surface cells of the antrum mucosa from where it is secreted. Belongs to the gastrokine family. extracellular region extracellular space signal transduction growth factor activity positive regulation of cell proliferation secretory granule positive regulation of cell division uc009cth.1 uc009cth.2 uc009cth.3 
ENSMUST00000032130.8 Aplf ENSMUST00000032130.8 aprataxin and PNKP like factor, transcript variant 3 (from RefSeq NM_001372332.1) APLF_MOUSE ENSMUST00000032130.1 ENSMUST00000032130.2 ENSMUST00000032130.3 ENSMUST00000032130.4 ENSMUST00000032130.5 ENSMUST00000032130.6 ENSMUST00000032130.7 NM_001372332 Q8BZL5 Q99LX6 Q9D842 uc009ctr.1 uc009ctr.2 uc009ctr.3 uc009ctr.4 Histone chaperone involved in single-strand and double-strand DNA break repair (By similarity). Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (By similarity). Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1 (PubMed:27875275). Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro (By similarity). Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (By similarity). Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721). Also acts as a negative regulator of cell pluripotency by promoting histone exchange (PubMed:27875275). Required for the embryo implantation during the epithelial to mesenchymal transition in females (PubMed:33277378). Interacts with LIG4 (By similarity). Interacts with PARP1 (By similarity). Interacts with XRCC4. Interacts (via KBM motif) with XRCC5 and XRCC6; promoting recruitment to DNA damage sites (By similarity). Interacts with XRCC1 (By similarity). Interacts (via C-terminal disordered region) with histones; interacts with histone H2A, H2B and H3-H4 (By similarity). Nucleus Chromosome Cytoplasm, cytosol Note=Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D842-1; Sequence=Displayed; Name=2; IsoId=Q9D842-2; Sequence=VSP_014983, VSP_014984; Name=3; IsoId=Q9D842-3; Sequence=VSP_014982, VSP_014984; Present in the 4-cell stage (PubMed:33277378). Expression is enhanced in early morula and late morula stage embryos (PubMed:33277378). Down-regulated during the first differentiation to form inner cell mass and trophectoderm within a blastocyst (32-cell stage) (PubMed:33277378). The PBZ-type zinc fingers (also named CYR) mediate non-covalent poly-ADP-ribose-binding. Specifically recognizes branched poly-ADP- ribose chains generated by PARP2. Poly-ADP-ribose-binding is dependent on the presence of zinc and promotes its recruitment to DNA damage sites. The KBM (Ku-binding motif) mediates interaction with XRCC5/Ku80 and XRCC6/Ku70 and recruitment to DNA damage sites. The FHA-like domain mediates interaction with XRCC1 and XRCC4. The NAP1L motif is required for the histone chaperone activity. Poly-ADP-ribosylated. In addition to binding non covalently poly- ADP-ribose via its PBZ-type zinc fingers, the protein is also covalently poly-ADP-ribosylated by PARP1. Phosphorylated in an ATM-dependent manner upon double-strand DNA break. Belongs to the APLF family. single strand break repair nucleotide binding DNA-(apurinic or apyrimidinic site) lyase activity endodeoxyribonuclease activity nucleus nucleoplasm chromosome cytoplasm cytosol DNA repair double-strand break repair cellular response to DNA damage stimulus 3'-5' exonuclease activity lyase activity site of double-strand break regulation of isotype switching metal ion binding positive regulation of DNA ligation nucleic acid phosphodiester bond hydrolysis uc009ctr.1 uc009ctr.2 uc009ctr.3 uc009ctr.4 
ENSMUST00000032133.5 Gp9 ENSMUST00000032133.5 glycoprotein 9 platelet (from RefSeq NM_018762.2) ENSMUST00000032133.1 ENSMUST00000032133.2 ENSMUST00000032133.3 ENSMUST00000032133.4 GPIX_MOUSE NM_018762 O88186 uc009ctv.1 uc009ctv.2 uc009ctv.3 The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib (By similarity). Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage (By similarity). Membrane ; Single-pass type I membrane protein molecular_function cell adhesion blood coagulation hemostasis biological_process membrane integral component of membrane uc009ctv.1 uc009ctv.2 uc009ctv.3 
ENSMUST00000032141.14 Hmces ENSMUST00000032141.14 5-hydroxymethylcytosine (hmC) binding, ES cell specific, transcript variant 9 (from RefSeq NR_184690.1) ENSMUST00000032141.1 ENSMUST00000032141.10 ENSMUST00000032141.11 ENSMUST00000032141.12 ENSMUST00000032141.13 ENSMUST00000032141.2 ENSMUST00000032141.3 ENSMUST00000032141.4 ENSMUST00000032141.5 ENSMUST00000032141.6 ENSMUST00000032141.7 ENSMUST00000032141.8 ENSMUST00000032141.9 HMCES_MOUSE Hmces NR_184690 Q8R1M0 Srap1 Srapd1 uc009cuh.1 uc009cuh.2 uc009cuh.3 uc009cuh.4 Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (By similarity). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (By similarity). The HMCES DNA-protein cross-link is then degraded by the proteasome (By similarity). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (By similarity). Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (By similarity). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (PubMed:31806351). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (PubMed:29020633). Interacts (via PIP-box motif) with PCNA. Chromosome Note=Recruited to chromatin following DNA damage. Localizes to replication forks. Expressed in embryonic stem cells. Glu-127 is involved in sensing abasic sites in single-stranded DNA (ssDNA). His-209 stabilizes the abasic sites by forming a hydrogen bond with the O4' hydroxyl group. Embryonic sublethality and altered DNA methylation, possibly caused by accumulation of 5-hydroxymethylcytosine (5hmC) in genomic DNA (PubMed:29020633). Mice do not show defects in hematopoiesis and no alterations in global 5hmC levels in bone marrow cells (PubMed:31806351). In contrast, mice display a decrease in class switch recombination (CSR) in mature activated B-cells (PubMed:31806351). Belongs to the SOS response-associated peptidase family. Was initially reported to specifically bind 5- hydroxymethylcytosine (5hmC)-containing DNA in stem cells (PubMed:23434322). It was later suggested to act as an endonuclease that specifically cleaves 5hmC-containing DNA (PubMed:29020633). However, recent studies question this activity: no alterations in global 5hmC levels are observed in bone marrow cells from knockout mice (PubMed:31806351). DNA binding single-stranded DNA binding nuclease activity endonuclease activity replication fork chromosome proteolysis cellular response to DNA damage stimulus peptidase activity hydrolase activity nucleic acid phosphodiester bond hydrolysis DNA-(apurinic or apyrimidinic site) lyase activity uc009cuh.1 uc009cuh.2 uc009cuh.3 uc009cuh.4 
ENSMUST00000032143.8 Rpn1 ENSMUST00000032143.8 ribophorin I (from RefSeq NM_133933.4) ENSMUST00000032143.1 ENSMUST00000032143.2 ENSMUST00000032143.3 ENSMUST00000032143.4 ENSMUST00000032143.5 ENSMUST00000032143.6 ENSMUST00000032143.7 NM_133933 Q3U985 Q91YQ5 RPN1_MOUSE Rpn1 uc009cva.1 uc009cva.2 uc009cva.3 uc009cva.4 Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Protein modification; protein glycosylation. Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Interacts with TMEM35A/NACHO (PubMed:32783947). Endoplasmic reticulum Endoplasmic reticulum membrane; Single-pass type I membrane protein Melanosome Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets. Belongs to the OST1 family. dolichyl-diphosphooligosaccharide-protein glycotransferase activity endoplasmic reticulum endoplasmic reticulum membrane rough endoplasmic reticulum cytosol protein glycosylation membrane integral component of membrane protein N-linked glycosylation via asparagine melanosome uc009cva.1 uc009cva.2 uc009cva.3 uc009cva.4 
ENSMUST00000032151.3 Eif4e3 ENSMUST00000032151.3 eukaryotic translation initiation factor 4E member 3 (from RefSeq NM_025829.4) ENSMUST00000032151.1 ENSMUST00000032151.2 IF4E3_MOUSE NM_025829 Q9D983 Q9DBB5 uc009dbr.1 uc009dbr.2 uc009dbr.3 Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity). EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3. Only expressed in heart, skeletal muscle, lung and spleen. Belongs to the eukaryotic initiation factor 4E family. RNA 7-methylguanosine cap binding RNA binding translation initiation factor activity mRNA cap binding complex translation translational initiation regulation of translation biological_process eukaryotic translation initiation factor 4F complex uc009dbr.1 uc009dbr.2 uc009dbr.3 
ENSMUST00000032157.9 Gxylt2 ENSMUST00000032157.9 glucoside xylosyltransferase 2 (from RefSeq NM_198612.2) ENSMUST00000032157.1 ENSMUST00000032157.2 ENSMUST00000032157.3 ENSMUST00000032157.4 ENSMUST00000032157.5 ENSMUST00000032157.6 ENSMUST00000032157.7 ENSMUST00000032157.8 GXLT2_MOUSE Glt8d4 NM_198612 Q810K9 uc009dca.1 uc009dca.2 uc009dca.3 Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose. Reaction=3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP- alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L- seryl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:56064, Rhea:RHEA-COMP:14610, Rhea:RHEA-COMP:14611, ChEBI:CHEBI:15378, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:140575, ChEBI:CHEBI:140576; EC=2.4.2.42; Evidence=; Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 8 family. cellular_component membrane integral component of membrane O-glycan processing transferase activity transferase activity, transferring glycosyl groups UDP-xylosyltransferase activity uc009dca.1 uc009dca.2 uc009dca.3 
ENSMUST00000032165.16 Ruvbl1 ENSMUST00000032165.16 RuvB-like AAA ATPase 1 (from RefSeq NM_019685.3) ENSMUST00000032165.1 ENSMUST00000032165.10 ENSMUST00000032165.11 ENSMUST00000032165.12 ENSMUST00000032165.13 ENSMUST00000032165.14 ENSMUST00000032165.15 ENSMUST00000032165.2 ENSMUST00000032165.3 ENSMUST00000032165.4 ENSMUST00000032165.5 ENSMUST00000032165.6 ENSMUST00000032165.7 ENSMUST00000032165.8 ENSMUST00000032165.9 NM_019685 Q3U1C2 Q3U1C2_MOUSE Ruvbl1 uc009cvh.1 uc009cvh.2 uc009cvh.3 Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Dynein axonemal particle Nucleus Belongs to the RuvB family. nucleotide binding Swr1 complex DNA helicase activity transcription coactivator activity helicase activity ATP binding nucleus nucleoplasm cytosol DNA repair DNA recombination cellular response to DNA damage stimulus hydrolase activity ATPase activity TBP-class protein binding Ino80 complex DNA duplex unwinding NuA4 histone acetyltransferase complex 5'-3' DNA helicase activity histone H4 acetylation histone H2A acetylation MLL1 complex positive regulation of canonical Wnt signaling pathway R2TP complex positive regulation of nucleic acid-templated transcription uc009cvh.1 uc009cvh.2 uc009cvh.3 
ENSMUST00000032168.7 Sec61a1 ENSMUST00000032168.7 SEC61 translocon subunit alpha 1 (from RefSeq NM_016906.4) ENSMUST00000032168.1 ENSMUST00000032168.2 ENSMUST00000032168.3 ENSMUST00000032168.4 ENSMUST00000032168.5 ENSMUST00000032168.6 NM_016906 P38378 P57726 P61620 Q3TXA5 S61A1_MOUSE Sec61a uc009cvi.1 uc009cvi.2 uc009cvi.3 Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post- translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (By similarity). Plays a critical role in nephrogenesis, specifically at pronephros stage (PubMed:27392076). The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (By similarity). The SEC61 channel associates with the multi-pass translocon (MPT) complex (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Localizes exclusively in granular structures in the endoplasmic reticulum (ER). When transfected in zebrafish, is able to rescue the pronephric kidney tubule development phenotype of the morpholino knockdown of the orthologous protein. Belongs to the SecY/SEC61-alpha family. signal sequence binding calcium channel activity endoplasmic reticulum Sec61 translocon complex endoplasmic reticulum membrane rough endoplasmic reticulum cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane, translocation posttranslational protein targeting to membrane endoplasmic reticulum organization multicellular organism development protein transmembrane transporter activity protein transport membrane integral component of membrane transmembrane transporter activity phagocytic vesicle membrane posttranslational protein targeting to membrane, translocation response to interferon-gamma pronephric nephron development ribosome binding calcium ion transmembrane transport uc009cvi.1 uc009cvi.2 uc009cvi.3 
ENSMUST00000032169.8 Abtb1 ENSMUST00000032169.8 ankyrin repeat and BTB domain containing 1, transcript variant 19 (from RefSeq NR_177272.1) A0A0R4J0A1 A0A0R4J0A1_MOUSE Abtb1 ENSMUST00000032169.1 ENSMUST00000032169.2 ENSMUST00000032169.3 ENSMUST00000032169.4 ENSMUST00000032169.5 ENSMUST00000032169.6 ENSMUST00000032169.7 NR_177272 uc009cvs.1 uc009cvs.2 uc009cvs.3 uc009cvs.4 nucleolus cytosol plasma membrane uc009cvs.1 uc009cvs.2 uc009cvs.3 uc009cvs.4 
ENSMUST00000032172.14 Chchd6 ENSMUST00000032172.14 coiled-coil-helix-coiled-coil-helix domain containing 6, transcript variant 1 (from RefSeq NM_025351.3) ENSMUST00000032172.1 ENSMUST00000032172.10 ENSMUST00000032172.11 ENSMUST00000032172.12 ENSMUST00000032172.13 ENSMUST00000032172.2 ENSMUST00000032172.3 ENSMUST00000032172.4 ENSMUST00000032172.5 ENSMUST00000032172.6 ENSMUST00000032172.7 ENSMUST00000032172.8 ENSMUST00000032172.9 MIC25_MOUSE Mic25 NM_025351 Q3UNQ1 Q91VN4 Q9D5I5 Q9DAM8 uc009cwh.1 uc009cwh.2 uc009cwh.3 uc009cwh.4 Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with DISC1. Interacts with IMMT/MIC60. Mitochondrion inner membrane ; Lipid-anchor Mitochondrion Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily. Sequence=BAB24193.1; Type=Frameshift; Evidence=; mitochondrion mitochondrial inner membrane cytosol cellular response to DNA damage stimulus membrane cristae formation MICOS complex uc009cwh.1 uc009cwh.2 uc009cwh.3 uc009cwh.4 
ENSMUST00000032174.12 Klf15 ENSMUST00000032174.12 Kruppel-like transcription factor 15, transcript variant 1 (from RefSeq NM_023184.4) Cklf ENSMUST00000032174.1 ENSMUST00000032174.10 ENSMUST00000032174.11 ENSMUST00000032174.2 ENSMUST00000032174.3 ENSMUST00000032174.4 ENSMUST00000032174.5 ENSMUST00000032174.6 ENSMUST00000032174.7 ENSMUST00000032174.8 ENSMUST00000032174.9 KLF15_MOUSE NM_023184 Q3UQB0 Q9EPW2 uc009cxj.1 uc009cxj.2 uc009cxj.3 Transcriptional regulator that binds to the GA element of the CLCNKA promoter (By similarity). Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. Is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A, GATA4 and MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation (By similarity). Involved in podocyte differentiation. Interacts with MYOCD. Interacts with EP300 (By similarity). Nucleus. Expressed in aortic smooth muscle cells. In the heart, up-regulated by the CLOCK/BMAL1 heterodimer. In podocytes, up-regulated by retinoic acid. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. KLF15 null mice are viable, but in response to pressure overload, they develop cardiac hypertrophy and fibrosis. Belongs to the Sp1 C2H2-type zinc-finger protein family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cellular glucose homeostasis nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter glial cell differentiation regulation of gene expression cardiac muscle hypertrophy in response to stress response to insulin transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import metal ion binding glomerular visceral epithelial cell differentiation cellular response to peptide negative regulation of peptidyl-lysine acetylation uc009cxj.1 uc009cxj.2 uc009cxj.3 
ENSMUST00000032179.14 Nup210 ENSMUST00000032179.14 nucleoporin 210 (from RefSeq NM_018815.2) ENSMUST00000032179.1 ENSMUST00000032179.10 ENSMUST00000032179.11 ENSMUST00000032179.12 ENSMUST00000032179.13 ENSMUST00000032179.2 ENSMUST00000032179.3 ENSMUST00000032179.4 ENSMUST00000032179.5 ENSMUST00000032179.6 ENSMUST00000032179.7 ENSMUST00000032179.8 ENSMUST00000032179.9 Kiaa0906 NM_018815 PO210_MOUSE Q3U031 Q69ZW2 Q7TQM1 Q9QY81 uc009cxu.1 uc009cxu.2 uc009cxu.3 uc009cxu.4 Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. Forms dimers and possibly higher-order oligomers. Nucleus, nuclear pore complex Nucleus membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single- pass type I membrane protein Preferential expressed in epithelial cells. In the kidney, expression was seen in both the epithelium derived from the ureteric tree and the mesenchyme-derived epithelium. In other tissues of 13-day-old embryos, expression was also confined to the epithelium. In nervous tissues, mainly expressed in the olfactory epithelium and walls of the lateral ventricle. Weak expression was seen in the heart. N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity). Phosphorylated at Ser-1880 in mitosis specifically; not phosphorylated in interphase. Belongs to the NUP210 family. nucleus nuclear envelope nuclear pore endoplasmic reticulum endoplasmic reticulum membrane protein transport membrane integral component of membrane nuclear membrane protein dimerization activity mRNA transport uc009cxu.1 uc009cxu.2 uc009cxu.3 uc009cxu.4 
ENSMUST00000032180.7 Wnt7a ENSMUST00000032180.7 wingless-type MMTV integration site family, member 7A, transcript variant 3 (from RefSeq NR_177083.1) ENSMUST00000032180.1 ENSMUST00000032180.2 ENSMUST00000032180.3 ENSMUST00000032180.4 ENSMUST00000032180.5 ENSMUST00000032180.6 NR_177083 P24383 Q80VH3 Q9DBY3 WNT7A_MOUSE Wnt-7a uc009cxz.1 uc009cxz.2 uc009cxz.3 Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (PubMed:18230341, PubMed:20530549, PubMed:23629626). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:7885472, PubMed:9769174, PubMed:9790192). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:28803732). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (PubMed:9790192). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (PubMed:23629626). Required for normal progress through the cell cycle in neural progenitor cells, for self- renewal of neural stem cells, and for normal neuronal differentiation and maturation (PubMed:23629626). Promotes formation of synapses via its interaction with FZD5 (PubMed:20530549). Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (By similarity). The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD5 (PubMed:18230341, PubMed:20530549). Interacts with PORCN (PubMed:10866835). Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (By similarity). Secreted, extracellular space, extracellular matrix Secreted Detected in the flanking ectoderm of the trunk prior to limb outgrowth. First detected in the presumptive forelimb region at 8.75 dpc, and in the presumptive hindlimb region at 9.25 dpc. Uniformly distributed throughout the dorsal limb ectoderm during the initial stages of limb-bud outgrowth (9.25 dpc for the forelimbs, 9.75 dpc for the hindlimbs). The intrinsically disordered linker region is required for recognition by RECK in brain endothelial cells. Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. Note=Defects in Wnt7a cause the postaxial hemimelia (px) phenotype that is characterized by limb patterning defects accompanied by Mullerian duct-associated sterility in both sexes. Male mice lacking Wnt7a fail to undergo regression of the Mullerian duct as a result of the absence of the receptor for Mullerian-inhibiting substance. In males, mature sperm fills the vas deferens, but sperm exit is blocked due to the persistence of the Mullerian duct, causing male sterility. Wnt7a deficient females are infertile because of abnormal development of the oviduct and uterus, both of which are Mullerian duct derivatives. Belongs to the Wnt family. embryonic axis specification cartilage condensation angiogenesis chondrocyte differentiation receptor binding frizzled binding cytokine activity extracellular region extracellular space endoplasmic reticulum lumen signal transduction cell-cell signaling neurotransmitter secretion multicellular organism development positive regulation of cell proliferation animal organ morphogenesis dorsal/ventral pattern formation cell surface positive regulation of endothelial cell migration positive regulation of gene expression skeletal muscle satellite cell activation skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Wnt signaling pathway cerebellar granule cell differentiation cell proliferation in forebrain central nervous system vasculogenesis establishment of cell polarity neuron differentiation embryonic limb morphogenesis extracellular matrix regulation of axon diameter positive regulation of cellular protein metabolic process response to estradiol somatic stem cell population maintenance embryonic forelimb morphogenesis embryonic hindlimb morphogenesis wound healing, spreading of epidermal cells non-canonical Wnt signaling pathway wound healing regulation of cell proliferation embryonic digit morphogenesis negative regulation of apoptotic process response to estrogen cell fate commitment asymmetric protein localization involved in cell fate determination positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade receptor agonist activity somatic stem cell division stem cell development negative regulation of neurogenesis regulation of axonogenesis synapse organization cartilage development positive regulation of synapse assembly positive regulation of epithelial cell proliferation involved in wound healing uterus development oviduct development canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway limb development dendritic spine morphogenesis uterus morphogenesis cellular response to transforming growth factor beta stimulus presynapse glutamatergic synapse positive regulation of excitatory synapse assembly regulation of presynapse assembly regulation of synaptic vesicle exocytosis positive regulation of excitatory postsynaptic potential uc009cxz.1 uc009cxz.2 uc009cxz.3 
ENSMUST00000032182.5 Xpc ENSMUST00000032182.5 xeroderma pigmentosum, complementation group C (from RefSeq NM_009531.2) ENSMUST00000032182.1 ENSMUST00000032182.2 ENSMUST00000032182.3 ENSMUST00000032182.4 NM_009531 P51612 P54732 Q3TKI2 Q920M1 Q9DBW7 XPC_MOUSE uc009cyd.1 uc009cyd.2 uc009cyd.3 uc009cyd.4 Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen- bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1. In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes. Component of the XPC complex composed of XPC, RAD23B and CETN2. Interacts with RAD23A; the interaction is suggesting the existence of a functional equivalent variant XPC complex. Interacts with TDG; the interaction is demonstrated using the XPC:RAD23B dimer. Interacts with SMUG1; the interaction is demonstrated using the XPC:RAD23B dimer. Interacts with DDB2. Interacts with CCNH, GTF2H1 and ERCC3. Interacts with E2F1 and KAT2A; leading to KAT2A recruitment to promoters and subsequent acetylation of histones. Nucleus Chromosome Cytoplasm Note=Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage. Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions. Ubiquitinated upon UV irradiation; the ubiquitination requires the UV-DDB complex, appears to be reversible and does not serve as a signal for degradation. Ubiquitinated by RNF11 via 'Lys-63'-linked ubiquitination. Ubiquitination by RNF111 is polysumoylation-dependent and promotes nucleotide excision repair. Sumoylated; sumoylation promotes ubiquitination by RNF111. Belongs to the XPC family. Sequence=AAC52500.1; Type=Frameshift; Evidence=; nucleotide-excision repair complex nucleotide-excision repair factor 2 complex nucleotide-excision repair, DNA damage recognition pyrimidine dimer repair by nucleotide-excision repair DNA binding damaged DNA binding single-stranded DNA binding nucleus nucleolus cytoplasm mitochondrion plasma membrane DNA repair nucleotide-excision repair mismatch repair cellular response to DNA damage stimulus response to UV-B response to auditory stimulus intra-S DNA damage checkpoint response to drug intracellular membrane-bounded organelle macromolecular complex binding UV-damage excision repair XPC complex regulation of mitotic cell cycle phase transition UV-damage excision repair, DNA incision uc009cyd.1 uc009cyd.2 uc009cyd.3 uc009cyd.4 
ENSMUST00000032183.6 Tmem43 ENSMUST00000032183.6 transmembrane protein 43 (from RefSeq NM_028766.3) ENSMUST00000032183.1 ENSMUST00000032183.2 ENSMUST00000032183.3 ENSMUST00000032183.4 ENSMUST00000032183.5 NM_028766 Q9DBS1 TMM43_MOUSE uc009cyc.1 uc009cyc.2 uc009cyc.3 May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (PubMed:18230648). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. In addition, functions as a critical signaling component in mediating NF- kappa-B activation by acting downstream of EGFR and upstream of CARD10 (By similarity). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing (PubMed:34050020). Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane (PubMed:18230648). Interacts with LMNA and LMNB2 (PubMed:18230648). Interacts with SUN2. Interacts with RNF26; this interaction is important to modulate innate immune signaling through the cGAS-STING pathway. Interacts with CARD10. Interacts with gap junctions proteins GJB2/Cx26 and GJB4/Cx30 (By similarity). Endoplasmic reticulum membrane Nucleus inner membrane ; Multi-pass membrane protein. Cell membrane Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen. Widely expressed, including in the cochlea, heart, eye, brain and kidney. In the cochlea, mainly expressed in the organ of Corti, along the entire cochlear length, at postnatal day 4 (P4) through P20. At P20, the expression becomes more restricted to the apical membrane of the inner border cells and the cell junctions of the inner sulcus cells. Throughout the early developmental period, up to P20, expression is mainly found at inner glia-like supporting cells of Kolliker's organ, while hair cell expression is comparably sparse. Expression in glia-like supporting cells is maintained in adulthood at 1, 2 and 4 months (at protein level). Belongs to the TMEM43 family. nucleus nuclear inner membrane integral component of nuclear inner membrane endoplasmic reticulum endoplasmic reticulum lumen Golgi apparatus membrane integral component of membrane protein self-association nuclear membrane organization uc009cyc.1 uc009cyc.2 uc009cyc.3 
ENSMUST00000032185.9 Slc6a6 ENSMUST00000032185.9 solute carrier family 6 (neurotransmitter transporter, taurine), member 6, transcript variant 10 (from RefSeq NR_177073.1) ENSMUST00000032185.1 ENSMUST00000032185.2 ENSMUST00000032185.3 ENSMUST00000032185.4 ENSMUST00000032185.5 ENSMUST00000032185.6 ENSMUST00000032185.7 ENSMUST00000032185.8 NR_177073 Q3UPI8 Q3UPI8_MOUSE Slc6a6 uc009cyh.1 uc009cyh.2 uc009cyh.3 uc009cyh.4 Reaction=4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) = 4- aminobutanoate(in) + chloride(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70687, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:59888; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70688; Evidence=; Reaction=beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta- alanine(in) + chloride(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71247, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57966; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71248; Evidence=; Reaction=chloride(out) + 2 Na(+)(out) + taurine(out) = chloride(in) + 2 Na(+)(in) + taurine(in); Xref=Rhea:RHEA:71223, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:507393; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71224; Evidence=; Reaction=chloride(out) + hypotaurine(out) + 2 Na(+)(out) = chloride(in) + hypotaurine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71243, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57853; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71244; Evidence=; Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily. neurotransmitter:sodium symporter activity taurine:sodium symporter activity integral component of plasma membrane neurotransmitter transport symporter activity taurine transport membrane integral component of membrane transmembrane transport uc009cyh.1 uc009cyh.2 uc009cyh.3 uc009cyh.4 
ENSMUST00000032191.16 Sumf1 ENSMUST00000032191.16 sulfatase modifying factor 1, transcript variant 1 (from RefSeq NM_145937.4) ENSMUST00000032191.1 ENSMUST00000032191.10 ENSMUST00000032191.11 ENSMUST00000032191.12 ENSMUST00000032191.13 ENSMUST00000032191.14 ENSMUST00000032191.15 ENSMUST00000032191.2 ENSMUST00000032191.3 ENSMUST00000032191.4 ENSMUST00000032191.5 ENSMUST00000032191.6 ENSMUST00000032191.7 ENSMUST00000032191.8 ENSMUST00000032191.9 Fge NM_145937 Q3TTT6 Q3TXM8 Q3U9A5 Q8R0F3 SUMF1_MOUSE Sumf1 uc009ddf.1 uc009ddf.2 uc009ddf.3 uc009ddf.4 Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. Reaction=2 a thiol + L-cysteinyl-[sulfatase] + O2 = 3-oxo-L-alanyl- [sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide; Xref=Rhea:RHEA:51152, Rhea:RHEA-COMP:12900, Rhea:RHEA-COMP:12901, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29256, ChEBI:CHEBI:29919, ChEBI:CHEBI:29950, ChEBI:CHEBI:35489, ChEBI:CHEBI:85621; EC=1.8.3.7; Evidence=; Name=Cu(2+); Xref=ChEBI:CHEBI:29036; Evidence=; Note=The catalytic copper is required to activate oxygen and catalyze oxidative C-H activation. ; Protein modification; sulfatase oxidation. Monomer, homodimer and heterodimer with SUMF2. Endoplasmic reticulum lumen N-glycosylated. Contains high-mannose-type oligosaccharides. Mice display frequent early mortality, congenital growth retardation, skeletal abnormalities and neurological defects. Defects are caused by absence of all sulfatases activities. Massive glycosaminoglycans accumulation and cell vacuolization are observed in all tissues and are associated with systemic inflammation, apoptosis and neurodegeneration. Belongs to the sulfatase-modifying factor family. The enzyme reaction was initially thought to act via a redox- active disulfide bond mechanism; however the disulfide bond only takes place with inactive enzyme that lacks the copper cofactor. The catalytic copper is required to activate oxygen and catalyze oxidative C-H activation. Sequence=AAH26981.1; Type=Erroneous initiation; Evidence=; Sequence=BAE30762.1; Type=Erroneous initiation; Evidence=; protein binding endoplasmic reticulum endoplasmic reticulum lumen oxidoreductase activity protein oxidation protein homodimerization activity post-translational protein modification metal ion binding oxidation-reduction process cupric ion binding uc009ddf.1 uc009ddf.2 uc009ddf.3 uc009ddf.4 
ENSMUST00000032192.9 Itpr1 ENSMUST00000032192.9 inositol 1,4,5-trisphosphate receptor 1 (from RefSeq NM_010585.5) ENSMUST00000032192.1 ENSMUST00000032192.2 ENSMUST00000032192.3 ENSMUST00000032192.4 ENSMUST00000032192.5 ENSMUST00000032192.6 ENSMUST00000032192.7 ENSMUST00000032192.8 ITPR1_MOUSE Insp3r NM_010585 P11881 P20943 Pcd6 Pcp1 Q99LG5 uc033itt.1 uc033itt.2 uc033itt.3 Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (PubMed:23542070). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium- dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with IRAG1 (PubMed:16990611). Interacts with CABP1 (via N-terminus) (By similarity). Interacts with TESPA1. Interacts (when not phosphorylated) with AHCYL1 (when phosphorylated); the interaction suppresses inositol 1,4,5-trisphosphate binding to ITPR1 and is increased in the presence of BCL2L10 (PubMed:23542070). Interacts with AHCYL2 (with lower affinity than with AHCYL1) (By similarity). Interacts with BCL2L10; the interaction is increased in the presence of AHCLY1 (By similarity). Interacts with BOK (via BH4 domain); protects ITPR1 from proteolysis by CASP3 during apoptosis (PubMed:23884412). P11881; Q8VDN2: Atp1a1; NbExp=3; IntAct=EBI-541478, EBI-444536; P11881; Q6PIE5: Atp1a2; NbExp=3; IntAct=EBI-541478, EBI-6665421; P11881; Q9D1Q6: Erp44; NbExp=5; IntAct=EBI-541478, EBI-541567; P11881; O35157: Slc8a1; NbExp=4; IntAct=EBI-541478, EBI-8351080; P11881; P10415: BCL2; Xeno; NbExp=3; IntAct=EBI-541478, EBI-77694; Endoplasmic reticulum membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region Note=Endoplasmic reticulum and secretory granules. Event=Alternative splicing; Named isoforms=8; Comment=There is a combination of two alternatively spliced domains at site SI and site SII (A, B and C). Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=SISIIABC; IsoId=P11881-1; Sequence=Displayed; Name=2; Synonyms=SI-SIIABC; IsoId=P11881-2; Sequence=VSP_002691; Name=3; Synonyms=SISIIAC; IsoId=P11881-3; Sequence=VSP_002693; Name=4; Synonyms=SI-SIIAC; IsoId=P11881-4; Sequence=VSP_002691, VSP_002693; Name=5; Synonyms=SISIIA; IsoId=P11881-5; Sequence=VSP_002693, VSP_002694; Name=6; Synonyms=SI-SIIA; IsoId=P11881-6; Sequence=VSP_002691, VSP_002693, VSP_002694; Name=7; Synonyms=SISII; IsoId=P11881-7; Sequence=VSP_002692, VSP_002693, VSP_002694; Name=8; Synonyms=SI-SII; IsoId=P11881-8; Sequence=VSP_002691, VSP_002692, VSP_002693, VSP_002694; The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylated by cAMP kinase (PKA). Phosphorylation prevents the ligand-induced opening of the calcium channels. Phosphorylation by PKA increases the interaction with inositol 1,4,5-trisphosphate and decreases the interaction with AHCYL1. Phosphorylated on tyrosine residues. Ubiquitination at multiple lysines targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'- linked (By similarity). Palmitoylated by ZDHHC6 in immune cells, leading to regulation of ITPR1 stability and function (PubMed:25368151). Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor. Belongs to the InsP3 receptor family. Sequence=AAA88319.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH03271.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; response to hypoxia ion channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity calcium channel activity calcium ion binding protein binding nuclear envelope nuclear inner membrane nucleolus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane calcineurin complex ion transport calcium ion transport apoptotic process positive regulation of cytosolic calcium ion concentration protein C-terminus binding post-embryonic development positive regulation of neuron projection development postsynaptic density calcium-release channel activity membrane integral component of membrane sarcoplasmic reticulum calcium channel inhibitor activity protein phosphatase binding integral component of endoplasmic reticulum membrane dendrite transport vesicle membrane cytoplasmic vesicle membrane secretory granule membrane smooth endoplasmic reticulum membrane platelet dense granule membrane platelet dense tubular network cytoplasmic vesicle endoplasmic reticulum calcium ion homeostasis macromolecular complex phosphatidylinositol binding epithelial fluid transport identical protein binding neuronal cell body positive regulation of apoptotic process intracellular membrane-bounded organelle macromolecular complex binding membrane raft inositol phosphate-mediated signaling perinuclear region of cytoplasm negative regulation of calcium-mediated signaling voluntary musculoskeletal movement release of sequestered calcium ion into cytosol protein homotetramerization positive regulation of calcium ion transport transmembrane transport intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding cellular response to cAMP synaptic membrane liver regeneration presynapse postsynapse GABA-ergic synapse regulation of postsynaptic cytosolic calcium ion concentration negative regulation of neuron death positive regulation of hepatocyte proliferation uc033itt.1 uc033itt.2 uc033itt.3 
ENSMUST00000032194.11 Bhlhe40 ENSMUST00000032194.11 basic helix-loop-helix family, member e40 (from RefSeq NM_011498.4) Bhlhb2 Bhlhe40 ENSMUST00000032194.1 ENSMUST00000032194.10 ENSMUST00000032194.2 ENSMUST00000032194.3 ENSMUST00000032194.4 ENSMUST00000032194.5 ENSMUST00000032194.6 ENSMUST00000032194.7 ENSMUST00000032194.8 ENSMUST00000032194.9 NM_011498 Q542A5 Q542A5_MOUSE uc009ddn.1 uc009ddn.2 This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK048242.1, AK154935.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Nucleus negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription corepressor activity nucleus regulation of transcription, DNA-templated circadian rhythm nuclear body protein domain specific binding circadian regulation of gene expression protein homodimerization activity bHLH transcription factor binding negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated protein heterodimerization activity protein dimerization activity E-box binding uc009ddn.1 uc009ddn.2 
ENSMUST00000032196.9 Arl8b ENSMUST00000032196.9 ADP-ribosylation factor-like 8B (from RefSeq NM_026011.3) ARL8B_MOUSE Arl10c Arl8b ENSMUST00000032196.1 ENSMUST00000032196.2 ENSMUST00000032196.3 ENSMUST00000032196.4 ENSMUST00000032196.5 ENSMUST00000032196.6 ENSMUST00000032196.7 ENSMUST00000032196.8 Gie1 NM_026011 Q3TXD7 Q3U769 Q3UBB1 Q3UJU2 Q9CQW2 uc009ddo.1 uc009ddo.2 uc009ddo.3 Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation (PubMed:33157038, PubMed:30174114). Along with its effectors, orchestrates lysosomal transport and fusion. Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (PubMed:30174114). Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense. Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes. Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing. Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (PubMed:21802320). Involved in the process of MHC II presentation. Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (PubMed:25637027). May play a role in chromosome segregation (By similarity). (Microbial infection) During infection, murine coronavirus (MHV) and the chaperone HSPA5/GRP78 are co-released through ARL8B- dependent lysosomal exocytic pathway for unconventional egress. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Interacts with tubulin. Interacts with BORCS5; recruits ARL8B to lysosomes. Interacts with VPS41; the interaction mediates the recruitment of the HOPS complex to lysosomes. Interacts (GTP-bound form) with PLEKHM2 (via RUN domain); the interaction is required to recruit the motor protein kinesin-1 on lysosomes. Interacts (GTP-bound form) with PLEKHM1 (via RUN domain); the interaction is required for PLEKHM1 localization to lysosomes and for ARL8B function in delivery and degradation of endocytic and autophagic cargo in lysosomes. PLEKHM1 and PLEKHM2 compete for interaction with ARL8B. Late endosome membrane Lysosome membrane toplasm, cytoskeleton, spindle Cell projection, axon Synapse Cytolytic granule membrane Note=GTP-bound form resides on lysosomal membranes, whereas GDP-bound form is likely associated with microtubular structures. Localizes with microtubules at the spindle mid-zone during mitosis (By similarity). In dendritic cells, localizes to MHC II+ compartments (PubMed:25637027). Ubiquitinated at Lys-141 by RNF167, leading to its degradation. Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTP binding cytoplasm lysosome lysosomal membrane endosome vacuolar membrane spindle cytoskeleton cell cycle chromosome segregation anterograde axonal transport protein transport membrane GDP binding cell junction axon midbody late endosome membrane lysosome localization cell projection alpha-tubulin binding synapse beta-tubulin binding spindle midzone cell division axon cytoplasm uc009ddo.1 uc009ddo.2 uc009ddo.3 
ENSMUST00000032198.11 Usp18 ENSMUST00000032198.11 ubiquitin specific peptidase 18 (from RefSeq NM_011909.2) ENSMUST00000032198.1 ENSMUST00000032198.10 ENSMUST00000032198.2 ENSMUST00000032198.3 ENSMUST00000032198.4 ENSMUST00000032198.5 ENSMUST00000032198.6 ENSMUST00000032198.7 ENSMUST00000032198.8 ENSMUST00000032198.9 NM_011909 Q3U7P3 Q9WTV6 UBP18_MOUSE Ubp43 uc009dog.1 uc009dog.2 uc009dog.3 Interferon-induced ISG15-specific protease that plays a crucial role for maintaining a proper balance of ISG15-conjugated proteins in cells (PubMed:11788588). Regulates protein ISGylation by efficiently cleaving ISG15 conjugates linked via isopeptide bonds. Regulates T-cell activation and T-helper 17 (Th17) cell differentiation by deubiquitinating TAK1, likely to keep TAK1-TAB complexes in steady conditions. In turn, restricts activation of NF-kappa-B, NFAT, and JNK as well as expression of IL2 in T-cells after TCR activation. Acts as a molecular adapter with USP20 to promote innate antiviral response through deubiquitinating STING1. Involved also in the negative regulation of the inflammatory response triggered by type I interferon. Upon recruitment by STAT2 to the type I interferon receptor subunit IFNAR2 interferes with the assembly of the ternary interferon-IFNAR1- IFNAR2 complex and acts as a negative regulator of the type I interferon signaling pathway. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with STAT2; the interaction is direct. Interacts with IFNAR2; indirectly via STAT2, it negatively regulates the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and inhibits type I interferon signaling. Interacts with STING1. Interacts with USP20. Q9WTV6; Q64339: Isg15; NbExp=4; IntAct=EBI-9119995, EBI-8345781; USP18-deletion mice display increased levels of intracellular ISG15 conjugates. Belongs to the peptidase C19 family. cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding nucleus cytosol proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity response to bacterium protein deubiquitination hydrolase activity ISG15-specific protease activity response to stilbenoid thiol-dependent ubiquitinyl hydrolase activity regulation of inflammatory response uc009dog.1 uc009dog.2 uc009dog.3 
ENSMUST00000032201.8 Ret ENSMUST00000032201.8 ret proto-oncogene, transcript variant 2 (from RefSeq NM_009050.2) ENSMUST00000032201.1 ENSMUST00000032201.2 ENSMUST00000032201.3 ENSMUST00000032201.4 ENSMUST00000032201.5 ENSMUST00000032201.6 ENSMUST00000032201.7 NM_009050 P35546 Q8BQ34 Q9QXH9 RET_MOUSE uc009dlm.1 uc009dlm.2 uc009dlm.3 Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration. Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT- signaling pathways (PubMed:28846099). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Repressed by withaferin A (WA). Phosphorylated form interacts with the PBT domain of DOK2, DOK4 and DOK5 (PubMed:11470823). The phosphorylated form interacts with PLCG1 and GRB7 (PubMed:8631863). Interacts (not phosphorylated) with PTK2/FAK1 (via FERM domain) (By similarity). Extracellular cell- membrane anchored RET cadherin fragments form complex in neurons with reduced trophic status, preferentially at the contact sites between somas (By similarity). Interacts with AIP in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex (By similarity). Binds to ARTN (PubMed:17322904). Interacts (inactive) with CBLC and CD2AP; dissociates upon activation by GDNF which increases CBLC:CD2AP interaction (PubMed:18753381). Interacts (via the extracellular domain) with GFRAL (via the extracellular domain); the interaction mediates cellular signaling upon interaction of GFRAL with its ligand GDF15 (PubMed:28846099). Interaction with GFRAL requires previous GDF15-binding to GFRAL (PubMed:28846099). Interacts with GFRA1; in the presence of SORL1, the GFRA1/RET complex is targeted to endosomes. Interacts with GDNF (By similarity). P35546-2; Q60629: Epha5; NbExp=5; IntAct=EBI-5548911, EBI-1267609; Cell membrane ; Single-pass type I membrane protein. Endosome membrane ; Single-pass type I membrane protein Note=Predominantly located on the plasma membrane. In the presence of SORL1 and GFRA1, directed to endosomes. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Ret51; IsoId=P35546-1; Sequence=Displayed; Name=2; Synonyms=Ret9; IsoId=P35546-2; Sequence=VSP_011304; Expressed in peripheral nerve cells, hematopoietic cells and podocytes (PubMed:18753381). Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (PubMed:28953886). Autophosphorylated on C-terminal tyrosine residues upon ligand stimulation. Proteolytically cleaved by caspase-3. The soluble RET kinase fragment is able to induce cell death. The extracellular cell-membrane anchored RET cadherin fragment accelerates cell adhesion in sympathetic neurons (By similarity). Exclusive loss in nociceptors results in a reduction in nociceptor number and size with a reduced epidermal innervation, but increased sensitivity to cold and increased formalin- induced pain. Treatment with withaferin A (WA) leads tumor regression in medullary thyroid carcinomas (MTC). Belongs to the protein kinase superfamily. Tyr protein kinase family. MAPK cascade nucleotide binding activation of MAPK activity ureteric bud development neural crest cell migration embryonic epithelial tube formation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity calcium ion binding protein binding ATP binding endosome early endosome cytosol plasma membrane integral component of plasma membrane protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules neuron cell-cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway nervous system development anatomical structure morphogenesis endosome membrane positive regulation of gene expression positive regulation of neuron projection development positive regulation of neuron maturation membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation regulation of cell adhesion neuron differentiation positive regulation of cell migration axon dendrite positive regulation of peptidyl-serine phosphorylation of STAT protein membrane protein proteolysis positive regulation of cell adhesion mediated by integrin ureter maturation glial cell-derived neurotrophic factor receptor signaling pathway response to drug neuron maturation neuronal cell body intracellular membrane-bounded organelle receptor complex positive regulation of MAPK cascade membrane raft positive regulation of cell size positive regulation of transcription, DNA-templated response to pain enteric nervous system development regulation of axonogenesis positive regulation of protein kinase B signaling retina development in camera-type eye innervation Peyer's patch morphogenesis cellular response to retinoic acid positive regulation of metanephric glomerulus development plasma membrane protein complex positive regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of peptidyl-serine phosphorylation of STAT protein uc009dlm.1 uc009dlm.2 uc009dlm.3 
ENSMUST00000032203.9 A2m ENSMUST00000032203.9 alpha-2-macroglobulin (from RefSeq NM_175628.3) A2MG_MOUSE A2m A2mp E9QMQ7 ENSMUST00000032203.1 ENSMUST00000032203.2 ENSMUST00000032203.3 ENSMUST00000032203.4 ENSMUST00000032203.5 ENSMUST00000032203.6 ENSMUST00000032203.7 ENSMUST00000032203.8 NM_175628 Q6GQT1 Q811S0 uc009doq.1 uc009doq.2 uc009doq.3 Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Homotetramer; disulfide-linked. Secreted Expressed in uterus, mesometrial lymphoid aggregate and mammary tissue during pregnancy. Expressed in ovary, testis and kidney. Low level expression in heart. Not expressed in liver. Expressed in uterus of pregnant females during decidualization from 6 dpc with highest level around 10 dpc declining throughout the rest of the pregnancy. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. negative regulation of complement activation, lectin pathway protease binding endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity receptor binding protein binding extracellular region extracellular space female pregnancy negative regulation of peptidase activity negative regulation of endopeptidase activity growth factor binding enzyme binding interleukin-8 binding interleukin-1 binding peptidase inhibitor activity protein homodimerization activity tumor necrosis factor binding calcium-dependent protein binding brain-derived neurotrophic factor binding nerve growth factor binding stem cell differentiation uc009doq.1 uc009doq.2 uc009doq.3 
ENSMUST00000032207.9 Klrg1 ENSMUST00000032207.9 killer cell lectin-like receptor subfamily G, member 1 (from RefSeq NM_016970.1) ENSMUST00000032207.1 ENSMUST00000032207.2 ENSMUST00000032207.3 ENSMUST00000032207.4 ENSMUST00000032207.5 ENSMUST00000032207.6 ENSMUST00000032207.7 ENSMUST00000032207.8 KLRG1_MOUSE Mafa NM_016970 O88713 Q3T1F0 uc009dov.1 uc009dov.2 uc009dov.3 uc009dov.4 uc009dov.5 Plays an inhibitory role on natural killer (NK) cells and T- cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E- cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. Forms a monomer and homodimer; disulfide-linked (By similarity). Interacts (via ITIM motif) with PTPN11 and INPP5D. Cell membrane ; Single-pass type II membrane protein Expressed specifically on natural killer (NK) cells and activated CD8 T-cells. Not detected in spleen, thymus, lymph node, testis, brain or kidney. Not detected on mast cell lines, bone marrow- derived mast cells, or peritoneal mast cells. By pathogens and viruses infections. Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases, PTPN11 and INPP5D. Phosphorylated in response to monoclonal antibody G63 binding and antigenic stimulation. Name=Functional Glycomics Gateway - Glycan Binding; Note=MCFA; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_176"; immune system process plasma membrane cell surface receptor signaling pathway membrane integral component of membrane carbohydrate binding intracellular membrane-bounded organelle innate immune response uc009dov.1 uc009dov.2 uc009dov.3 uc009dov.4 uc009dov.5 
ENSMUST00000032211.5 Gdf3 ENSMUST00000032211.5 growth differentiation factor 3 (from RefSeq NM_008108.5) ENSMUST00000032211.1 ENSMUST00000032211.2 ENSMUST00000032211.3 ENSMUST00000032211.4 GDF3_MOUSE Gdf-3 NM_008108 Q07104 Q3TUX1 Vgr-2 uc009dpm.1 uc009dpm.2 uc009dpm.3 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is important in embryogenesis and likely plays a role ocular and skeletal development. Mice lacking a functional copy of this gene exhibit defects in early embryonic development resulting in embryonic lethality. [provided by RefSeq, Aug 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK152457.1, AK082877.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor CRIPTO (PubMed:16368929, PubMed:17936261). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and CRIPTO. Homodimer. Heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked. Secreted Cytoplasm Note=Mainly accumulated in the cytoplasm. Primarily in adult bone marrow, spleen, thymus and adipose tissue. Markedly increased in an obese-mouse model lacking adipocyte fatty acid-binding protein FABP4. Synthesized as large precursor molecule that undergo proteolytic cleavage, releasing the pro-domain from the active, receptor binding, C-terminal region of the molecule. Embryonic lethality in one-third of the mutant embryos because of pregastrulation developmental malformations. However, the majority of mutants survive until adulthood without any overt abnormality (PubMed:17936261, PubMed:16368929). Mutant mice shown resistance to diet-induced obesity (PubMed:18480259). In contrast to other members of this family, cannot be disulfide-linked due to an atypical cysteine knot configuration, where the fourth cysteine is missing. This fourth cysteine is involved in an inter-molecular bridge to stabilize the active form of homodimeric or heterodimeric signaling molecules. Belongs to the TGF-beta family. skeletal system development eye development in utero embryonic development response to dietary excess cytokine activity transforming growth factor beta receptor binding protein binding extracellular region extracellular space cytoplasm signal transduction multicellular organism development endoderm development mesoderm development growth factor activity regulation of cell fate commitment positive regulation of pathway-restricted SMAD protein phosphorylation protein kinase binding BMP signaling pathway negative regulation of BMP signaling pathway notochord development somite rostral/caudal axis specification regulation of apoptotic process regulation of MAPK cascade positive regulation of fat cell differentiation negative regulation of epidermal cell differentiation negative regulation of myoblast differentiation cell development formation of anatomical boundary SMAD protein signal transduction primitive streak formation uc009dpm.1 uc009dpm.2 uc009dpm.3 
ENSMUST00000032216.7 Ptms ENSMUST00000032216.7 parathymosin (from RefSeq NM_026988.2) ENSMUST00000032216.1 ENSMUST00000032216.2 ENSMUST00000032216.3 ENSMUST00000032216.4 ENSMUST00000032216.5 ENSMUST00000032216.6 NM_026988 PTMS_MOUSE Q9D0J8 uc009dsm.1 uc009dsm.2 uc009dsm.3 uc009dsm.4 Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections. Belongs to the pro/parathymosin family. immune system process cytosol biological_process zinc ion binding uc009dsm.1 uc009dsm.2 uc009dsm.3 uc009dsm.4 
ENSMUST00000032217.2 Lag3 ENSMUST00000032217.2 lymphocyte-activation gene 3 (from RefSeq NM_008479.2) ENSMUST00000032217.1 LAG3_MOUSE Lag3 NM_008479 Q0VBL2 Q61790 uc009dsl.1 uc009dsl.2 uc009dsl.3 uc009dsl.4 Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887, PubMed:30580966). Delivers inhibitory signals upon binding to ligands, such as FGL1 (PubMed:30580966). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (PubMed:21300912). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (PubMed:15485628). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (PubMed:19201841). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:12209638, PubMed:12421911, PubMed:15634887). [Secreted lymphocyte activation gene 3 protein]: May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response. Interacts with MHC class II (MHC-II); selectively recognizes stable complexes of peptide and MHC-II (PubMed:12209638, PubMed:12421911, PubMed:30349037). Interacts with FGL1 (via the Fibrinogen C-terminal domain) (PubMed:30580966). Q61790; Q71KU9: Fgl1; NbExp=3; IntAct=EBI-34579204, EBI-34579174; Q61790; Q08830: FGL1; Xeno; NbExp=2; IntAct=EBI-34579204, EBI-3934830; [Lymphocyte activation gene 3 protein]: Cell membrane ; Single-pass type I membrane protein [Secreted lymphocyte activation gene 3 protein]: Secreted Note=Produced following cleavage of the main chain. Primarily expressed in activated CD4(+) and CD8(+) T-cells (PubMed:12209638). Also expressed in a subset of regulatory T- cells (Tregs), such as natural CD4(+)CD25(+) Tregs (PubMed:15485628). Also expressed on plasmacytoid dendritic cells (pDCs) (PubMed:19201841). [Lymphocyte activation gene 3 protein]: The KIEELE motif is required for interaction with downstream signaling molecules. [Lymphocyte activation gene 3 protein]: Proteolytically cleaved by ADAM10 and ADAM17 within the connecting peptide region, leading to release of Secreted lymphocyte activation gene 3 protein (sLAG-3) (PubMed:17245433). ADAM10 mediates constitutive cleavage, but cleavage increases following T-cell activation, whereas shedding by ADAM17 is induced by TCR signaling in a PRKCQ-dependent manner (PubMed:17245433). Mice develop normally but show minor defects in the natural killer (NK) cells (PubMed:8602528). They are however prone to development of autoimmune diseases, such as autoimmune diabetes on a permissive genetic background (PubMed:21300912, PubMed:21873518). Knockout NOD mice exhibit accelerated, invasive insulitis, corresponding to increased CD4(+) and CD8(+) T-cell islet infiltration and intraislet proliferation (PubMed:21873518). T-cells display a delay in cell cycle arrest following stimulation with the superantigen staphylococcal enterotoxin-B resulting in increased T-cell expansion and splenomegaly (PubMed:15100286). Mice lacking both Lag3 and Pdcd1/PD-1 die of severe myocarditis before 10 weeks of age in BALB/c mice (PubMed:21300912). Belongs to the LAG3 family. An initial knockout experiment in mouse reported only minor phenotype with no development of spontaneous disease, arguing against a significant role in controlling T-cell activation (PubMed:8602528). However, subsequent analysis showed that knockout mice develop autoimmune diseases caused by T-cell activation (PubMed:21873518). adaptive immune response plasmacytoid dendritic cell activation immune system process transmembrane signaling receptor activity protein binding extracellular region plasma membrane cell surface receptor signaling pathway external side of plasma membrane membrane integral component of membrane MHC class II protein binding negative regulation of interleukin-2 biosynthetic process negative regulation of regulatory T cell differentiation positive regulation of natural killer cell mediated cytotoxicity regulation of immune response negative regulation of T cell activation uc009dsl.1 uc009dsl.2 uc009dsl.3 uc009dsl.4 
ENSMUST00000032220.15 Cops7a ENSMUST00000032220.15 COP9 signalosome subunit 7A, transcript variant 1 (from RefSeq NM_012003.4) CSN7A_MOUSE Csn7a ENSMUST00000032220.1 ENSMUST00000032220.10 ENSMUST00000032220.11 ENSMUST00000032220.12 ENSMUST00000032220.13 ENSMUST00000032220.14 ENSMUST00000032220.2 ENSMUST00000032220.3 ENSMUST00000032220.4 ENSMUST00000032220.5 ENSMUST00000032220.6 ENSMUST00000032220.7 ENSMUST00000032220.8 ENSMUST00000032220.9 NM_012003 O88546 Q925R8 Q9CPQ4 Q9CWD2 Q9CZ04 uc009dss.1 uc009dss.2 uc009dss.3 uc009dss.4 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with PMF1. Interacts with the translation initiation factor EIF3S6. Interacts with CK2 and PKD (By similarity). Interacts directly with ID3 (PubMed:15451666). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZ04-1; Sequence=Displayed; Name=2; IsoId=Q9CZ04-2; Sequence=VSP_011912; Phosphorylated by CK2 and PKD kinases. Belongs to the CSN7/EIF3M family. CSN7 subfamily. Sequence=AAK43736.1; Type=Frameshift; Evidence=; Sequence=BAB27144.1; Type=Frameshift; Evidence=; protein deneddylation molecular_function nucleus nucleoplasm cytoplasm cytosol COP9 signalosome COP9 signalosome assembly uc009dss.1 uc009dss.2 uc009dss.3 uc009dss.4 
ENSMUST00000032228.9 Mug1 ENSMUST00000032228.9 murinoglobulin 1 (from RefSeq NM_008645.3) ENSMUST00000032228.1 ENSMUST00000032228.2 ENSMUST00000032228.3 ENSMUST00000032228.4 ENSMUST00000032228.5 ENSMUST00000032228.6 ENSMUST00000032228.7 ENSMUST00000032228.8 MUG1_MOUSE Mug-1 NM_008645 P28665 Q3UNE7 Q80XE6 uc009dor.1 uc009dor.2 A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective. Monomer. Secreted. Plasma. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. protease binding endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity extracellular region extracellular space embryo implantation negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc009dor.1 uc009dor.2 
ENSMUST00000032233.9 Tuba8 ENSMUST00000032233.9 tubulin, alpha 8 (from RefSeq NM_017379.2) D4P911 ENSMUST00000032233.1 ENSMUST00000032233.2 ENSMUST00000032233.3 ENSMUST00000032233.4 ENSMUST00000032233.5 ENSMUST00000032233.6 ENSMUST00000032233.7 ENSMUST00000032233.8 NM_017379 Q9CV57 Q9JJZ2 TBA8_MOUSE uc009dof.1 uc009dof.2 uc009dof.3 uc009dof.4 This gene encodes a member of the tubulin family of cytoskeletal proteins that form the integral component of microtubules. This gene is preferentially expressed in heart, skeletal muscle and testis. The encoded protein may play a role in liver tumorigenesis in mice. [provided by RefSeq, Sep 2015]. ##Evidence-Data-START## Transcript exon combination :: BC017631.1, AJ245923.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Cytoplasm, cytoskeleton. Expressed at highest levels in the testis, followed by skeletal and heart muscle. Expressed at low levels in the developing brain. At embryonic day (E) 13.5, expressed in the cortical preplate and cingulate cortex. By 15.5 dpc, the strongest expression is seen in the cortical plate. By 18.5 dpc, cortical expression is most intense in the upper layers and subplate. There is strong expression in the areas CA1-3 of the hippocampus. At P0, cortical expression is strongest in the dense cortical plate and subplate. Hippocampal expression is more intense in areas CA1-3 than in the dentate gyrus. At P8, lamination is almost complete and cortical expression is strongest in layers II-III and V and the subplate. There is also expression in the mediodorsal nuclei of the thalamus, the mitral cell layer of the olfactory bulb, and the external granular layer, molecular layer, and internal granular cell layer of the cerebellum. The MREC motif may be critical for tubulin autoregulation. Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility (PubMed:33414192). Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:15890843). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (PubMed:23897886). The C-terminal phenylalanine residue is cleaved by KIAA0895L/MATCAP. This tubulin does not have a C-terminal tyrosine; however, its C-terminal phenylalanine residue can be cleaved. Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle GTPase activity structural constituent of cytoskeleton GTP binding cytoplasm cytoskeleton microtubule microtubule-based process microtubule cytoskeleton uc009dof.1 uc009dof.2 uc009dof.3 uc009dof.4 
ENSMUST00000032234.5 Cd163 ENSMUST00000032234.5 CD163 antigen, transcript variant 2 (from RefSeq NM_053094.2) A6H691 C163A_MOUSE ENSMUST00000032234.1 ENSMUST00000032234.2 ENSMUST00000032234.3 ENSMUST00000032234.4 M130 NM_053094 Q2VLH5 Q2VLH6 Q99MX8 uc009dqn.1 uc009dqn.2 uc009dqn.3 uc009dqn.4 Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). After shedding, the soluble form (sCD163) may play an anti- inflammatory role. Interacts with CSNK2B. [Soluble CD163]: Secreted Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CD163v2; IsoId=Q2VLH6-1; Sequence=Displayed; Name=2; Synonyms=CD163v3; IsoId=Q2VLH6-2; Sequence=VSP_019016; Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen and mesenteric lymph nodes. Induced by anti-inflammatory mediators such as glucocorticoids and IL10; suppressed by IL4. The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes. A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs (By similarity). scavenger receptor activity extracellular region plasma membrane endocytosis acute-phase response inflammatory response external side of plasma membrane membrane integral component of membrane uc009dqn.1 uc009dqn.2 uc009dqn.3 uc009dqn.4 
ENSMUST00000032237.8 Bms1 ENSMUST00000032237.8 BMS1, ribosome biogenesis factor (from RefSeq NM_194339.2) Bms1 ENSMUST00000032237.1 ENSMUST00000032237.2 ENSMUST00000032237.3 ENSMUST00000032237.4 ENSMUST00000032237.5 ENSMUST00000032237.6 ENSMUST00000032237.7 NM_194339 Q6PGF5 Q6PGF5_MOUSE uc009dlo.1 uc009dlo.2 uc009dlo.3 Nucleus, nucleolus maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GTPase activity GTP binding nucleus nucleolus 90S preribosome U3 snoRNA binding ribosome biogenesis uc009dlo.1 uc009dlo.2 uc009dlo.3 
ENSMUST00000032238.5 Vmn2r26 ENSMUST00000032238.5 vomeronasal 2, receptor 26 (from RefSeq NM_019917.2) ENSMUST00000032238.1 ENSMUST00000032238.2 ENSMUST00000032238.3 ENSMUST00000032238.4 NM_019917 O70409 Q6TAC4 V2R26_MOUSE V2r1b uc009dqm.1 uc009dqm.2 uc009dqm.3 Putative pheromone receptor. Cell membrane ; Multi-pass membrane protein Expressed in the basal epithelium of the vomeronasal organ. Located to vomeronasal sensory neurons that project their axons to six to ten glomeruli that reside in globally conserved areas within the caudal accessory olfactory bulb (AOB). Belongs to the G-protein coupled receptor 3 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane response to pheromone neuron differentiation G-protein coupled olfactory receptor activity signaling receptor activity detection of chemical stimulus involved in sensory perception of smell uc009dqm.1 uc009dqm.2 uc009dqm.3 
ENSMUST00000032239.11 Clec4e ENSMUST00000032239.11 C-type lectin domain family 4, member e (from RefSeq NM_019948.2) CLC4E_MOUSE Clec4e Clecsf9 ENSMUST00000032239.1 ENSMUST00000032239.10 ENSMUST00000032239.2 ENSMUST00000032239.3 ENSMUST00000032239.4 ENSMUST00000032239.5 ENSMUST00000032239.6 ENSMUST00000032239.7 ENSMUST00000032239.8 ENSMUST00000032239.9 Mincle NM_019948 Q9R0Q8 uc009dqk.1 uc009dqk.2 uc009dqk.3 Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage- associated molecular patterns (DAMPs) of abnormal self and pathogen- associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18509109, PubMed:18490740, PubMed:18776906, PubMed:20008526, PubMed:19171887, PubMed:23602766). The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:20008526, PubMed:23602766). Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (PubMed:23602766, PubMed:18776906). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen- specific priming of T-cells toward effector T-helper 1 (Th1) and T- helper 17 (Th17) cell subtypes (PubMed:23602766). Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation (PubMed:19171887). Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue (PubMed:18776906). Monomer and homodimer (PubMed:18509109). Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex; the interaction is direct (PubMed:23602766). Alternatively, acts as a bridge for interaction between CLEC4D and FCER1G. A heterodimer of CLEC4E and CLEC4D associates with FCER1G to form a functional complex (By similarity). Interacts with SAP130 nuclear protein that is released from necrotic cells; the interaction is direct (PubMed:23602766). Cell membrane ingle-pass type II membrane protein Cell projection, phagocytic cup Highly expressed in macrophages in response to stimulation with bacterial glycolipids and pro-inflammatory cytokines (PubMed:10528209). Expressed in dendritic cells (at protein level) in response to stimulation with mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed:23602766). Expression is induced upon exposure to bacterial glycolipids including lipopolysaccharide (LPS) and mycobacterial trehalose 6,6'- dimycolate (TDM) and several pro-inflammatory cytokines, including IFNG and TNF (PubMed:10528209, PubMed:23602766). Rapidly induced in thymus in response to whole-body irradiation and excessive cell death (PubMed:18776906). Induced in macrophages in response to C.albicans infection (PubMed:18490740). Knockout mice are born at the expected Mendelian rate (PubMed:19171887, PubMed:23602766). When compared to wild-type littermates, deficient mice show resistance to lethal systemic inflammation caused by exposure to mycobacterial cord factor/trehalose 6,6'-dimycolate (TDM) (PubMed:23602766). Mice are also susceptibility to systemic candidiasis (PubMed:18490740). Name=Functional Glycomics Gateway - Glycan Binding; Note=Mincle; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_167"; pattern recognition receptor signaling pathway T cell differentiation involved in immune response immune system process calcium ion binding protein binding immune response membrane integral component of membrane carbohydrate binding signaling receptor activity Fc-gamma receptor signaling pathway pattern recognition receptor activity defense response to bacterium innate immune response metal ion binding positive regulation of cytokine secretion uc009dqk.1 uc009dqk.2 uc009dqk.3 
ENSMUST00000032240.4 Clec4d ENSMUST00000032240.4 C-type lectin domain family 4, member d, transcript variant 1 (from RefSeq NM_010819.4) CLC4D_MOUSE Clec4d Clecsf8 ENSMUST00000032240.1 ENSMUST00000032240.2 ENSMUST00000032240.3 Mcl NM_010819 Q8C212 Q9Z2H6 uc009dqg.1 uc009dqg.2 uc009dqg.3 uc009dqg.4 Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage- associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed:23602766, PubMed:23911656). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T- helper 17 cell subtypes (PubMed:23602766, PubMed:23911656). The heterodimer formed with CLEC6A is active against fungal infection (By similarity). Functions as an endocytic receptor (By similarity). May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (By similarity). Heterodimer with CLEC4E; disulfide-linked. CLEC4E acts as a bridge for interaction between CLEC4D and FCER1G to form a functional complex (By similarity). Heterodimer with CLEC6A; this heterodimer forms a pattern recognition receptor (PRR) against fungal infection (By similarity). Cell membrane ; Single-pass type II membrane protein Constitutively expressed in myeloid cells including dendritic cells (at protein level) (PubMed:23602766). Expressed in the macrophage populations of bone marrow, spleen, lung and lymph nodes (PubMed:9660840). Knockout mice are born at the expected Mendelian rate (PubMed:23602766). When compared to wild-type littermates, deficient mice show resistance to lethal systemic inflammation caused by exposure to mycobacterial cord factor/trehalose 6,6'-dimycolate (TDM) (PubMed:23602766). Mice are also susceptibility to C.albicans infections (PubMed:23911656). Name=Functional Glycomics Gateway - Glycan Binding; Note=MCL; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_161"; adaptive immune response T cell differentiation involved in immune response immune system process plasma membrane membrane integral component of membrane carbohydrate binding positive regulation of myeloid dendritic cell activation immunoglobulin receptor binding Fc-gamma receptor signaling pathway defense response to bacterium innate immune response metal ion binding uc009dqg.1 uc009dqg.2 uc009dqg.3 uc009dqg.4 
ENSMUST00000032257.10 Klrb1f ENSMUST00000032257.10 killer cell lectin-like receptor subfamily B member 1F, transcript variant 1 (from RefSeq NM_153094.2) ENSMUST00000032257.1 ENSMUST00000032257.2 ENSMUST00000032257.3 ENSMUST00000032257.4 ENSMUST00000032257.5 ENSMUST00000032257.6 ENSMUST00000032257.7 ENSMUST00000032257.8 ENSMUST00000032257.9 KLRBF_MOUSE NM_153094 Nkrp1f Q1AFZ8 Q3TDT3 Q8C9Q1 Q8VD98 uc009efa.1 uc009efa.2 uc009efa.3 uc009efa.4 Binds CLEC2I/Clr-g leading to activation of natural killer cells or costimulation of IL-2 production and proliferation of T-cells in response to antigen stimulation. May contribute to the formation of the immunological synapse between T-cells and antigen-presenting dendritic cells. Membrane ; Single-pass type II membrane protein Highly expressed in dendritic cells. Detectable in natural killer cells. protein binding plasma membrane cell surface membrane integral component of membrane carbohydrate binding signaling receptor activity uc009efa.1 uc009efa.2 uc009efa.3 uc009efa.4 
ENSMUST00000032258.8 Clec2e ENSMUST00000032258.8 C-type lectin domain family 2, member e (from RefSeq NM_153506.4) Clec2e ENSMUST00000032258.1 ENSMUST00000032258.2 ENSMUST00000032258.3 ENSMUST00000032258.4 ENSMUST00000032258.5 ENSMUST00000032258.6 ENSMUST00000032258.7 H7BWZ4 H7BWZ4_MOUSE NM_153506 uc009efd.1 uc009efd.2 uc009efd.3 uc009efd.4 membrane integral component of membrane carbohydrate binding uc009efd.1 uc009efd.2 uc009efd.3 uc009efd.4 
ENSMUST00000032259.6 Cd69 ENSMUST00000032259.6 CD69 antigen (from RefSeq NM_001033122.4) Cd69 ENSMUST00000032259.1 ENSMUST00000032259.2 ENSMUST00000032259.3 ENSMUST00000032259.4 ENSMUST00000032259.5 NM_001033122 Q3U6A8 Q3U6A8_MOUSE uc009efi.1 uc009efi.2 uc009efi.3 membrane integral component of membrane carbohydrate binding macromolecular complex protein homodimerization activity uc009efi.1 uc009efi.2 uc009efi.3 
ENSMUST00000032260.6 Clec2d ENSMUST00000032260.6 C-type lectin domain family 2, member d (from RefSeq NM_053109.3) CLC2D_MOUSE Clrb ENSMUST00000032260.1 ENSMUST00000032260.2 ENSMUST00000032260.3 ENSMUST00000032260.4 ENSMUST00000032260.5 NM_053109 Ocil Q1AFZ3 Q8VI19 Q8VI20 Q91V08 uc009efe.1 uc009efe.2 uc009efe.3 uc009efe.4 Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis (PubMed:14990792, PubMed:16751398). Inhibits osteoclast formation (PubMed:11278931, PubMed:12374791). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656). Homodimer; disulfide-linked. Cell membrane ingle-pass type II membrane protein Detected in fetal heart, brain, lung, chondrocytes, perichondrium and osteoblasts, and in adult splenocytes, thymocytes, lymph-node cells, osteoblasts, growth plate chondrocytes and skeletal muscle overlying the bone (at protein level). Ubiquitous. Detected in thymus, bone marrow, lung, gut, heart, skeletal muscle, ovary, spleen, ileum, liver and kidney. Constitutively expressed in bone marrow cells. Down- regulated by treatment with 1,25-dihydroxyvitamin D3. Up-regulated in calvarial osteoblast cells by IL-1alpha, IL11, and 1,25- dihydroxyvitamin D3. N-glycosylated. transmembrane signaling receptor activity protein binding plasma membrane integral component of plasma membrane cellular defense response external side of plasma membrane membrane integral component of membrane carbohydrate binding protection from natural killer cell mediated cytotoxicity negative regulation of osteoclast differentiation natural killer cell lectin-like receptor binding uc009efe.1 uc009efe.2 uc009efe.3 uc009efe.4 
ENSMUST00000032262.14 Clec1b ENSMUST00000032262.14 C-type lectin domain family 1, member b, transcript variant 1 (from RefSeq NM_019985.3) A0T1G2 CLC1B_MOUSE Clec2 ENSMUST00000032262.1 ENSMUST00000032262.10 ENSMUST00000032262.11 ENSMUST00000032262.12 ENSMUST00000032262.13 ENSMUST00000032262.2 ENSMUST00000032262.3 ENSMUST00000032262.4 ENSMUST00000032262.5 ENSMUST00000032262.6 ENSMUST00000032262.7 ENSMUST00000032262.8 ENSMUST00000032262.9 NM_019985 Q9JL99 uc009efo.1 uc009efo.2 uc009efo.3 uc009efo.4 C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2. Homodimer. Interacts (via cytoplasmic domain) with RACK1; promotes CLEC1B ubiquitination and proteasome-mediated degradation. Interacts (dimer) with SYK (via SH2 domains) (By similarity). Interacts with PDPN; the interaction is independent of CLEC1B glycosylation and activates CLEC1B (By similarity). Membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A; IsoId=Q9JL99-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9JL99-2; Sequence=VSP_023516; Hematopoietic cells, megakaryocytes and platelets. Glycosylated. Phosphorylated on tyrosine residue in response to rhodocytin binding. Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2 (PubMed:16174766). transmembrane signaling receptor activity integral component of plasma membrane cell surface receptor signaling pathway membrane integral component of membrane signal transduction by protein phosphorylation platelet formation carbohydrate binding uc009efo.1 uc009efo.2 uc009efo.3 uc009efo.4 
ENSMUST00000032263.7 Tmem52b ENSMUST00000032263.7 transmembrane protein 52B (from RefSeq NM_001081186.1) ENSMUST00000032263.1 ENSMUST00000032263.2 ENSMUST00000032263.3 ENSMUST00000032263.4 ENSMUST00000032263.5 ENSMUST00000032263.6 NM_001081186 Q0VBF2 TM52B_MOUSE uc009efx.1 uc009efx.2 uc009efx.3 Membrane ; Single-pass type I membrane protein molecular_function biological_process membrane integral component of membrane uc009efx.1 uc009efx.2 uc009efx.3 
ENSMUST00000032264.9 Gabarapl1 ENSMUST00000032264.9 GABA type A receptor associated protein like 1 (from RefSeq NM_020590.4) Apg8l Atg8l ENSMUST00000032264.1 ENSMUST00000032264.2 ENSMUST00000032264.3 ENSMUST00000032264.4 ENSMUST00000032264.5 ENSMUST00000032264.6 ENSMUST00000032264.7 ENSMUST00000032264.8 GBRL1_MOUSE Gabarapl1 Gec1 MNCb-0091 NM_020590 Q3TG14 Q3TJB9 Q3TXZ5 Q8R3R8 Q9JJ97 uc009efz.1 uc009efz.2 uc009efz.3 Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Interacts with ATG13, OPRK1, RB1CC1 and ULK1 (By similarity). Interacts with TP53INP1 and TP53INP2 (By similarity). Directly interacts with SQSTM1 (By similarity). Interacts with ATG3, ATG7 and MAP15 (PubMed:16704426). Interacts with TECPR2 (By similarity). Interacts with TBC1D5 (By similarity). Interacts with MAPK15 (By similarity). Interacts with TRIM5 (By similarity). Interacts with MEFV and TRIM21 (By similarity). Interacts with WDFY3 (By similarity). Interacts with the reticulophagy receptor TEX264 (By similarity). Interacts with UBA5 (By similarity). Interacts with KBTBD6 and KBTBD7; the interaction is direct (By similarity). Interacts with reticulophagy regulators RETREG1, RETREG2 and RETREG3 (PubMed:34338405). Interacts with Irgm1 (By similarity). Interacts with DNM2 (By similarity). Cytoplasmic vesicle, autophagosome Cytoplasmic vesicle membrane ; Lipid-anchor Cytoplasm, cytoskeleton Endoplasmic reticulum Golgi apparatus Expressed in testis and heart at high levels. The precursor molecule is cleaved by ATG4 (ATG4A, ATG4B, ATG4C or ATG4D) to expose the glycine at the C-terminus and form the cytosolic form, GABARAPL1-I (PubMed:14530254, PubMed:16704426). The processed form is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, GABARAPL1-II (By similarity). During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid (By similarity). ATG4 proteins also mediate the delipidation of PE-conjugated forms required for GABARAPL1 recycling when autophagosomes fuse with lysosomes (PubMed:33795848). In addition, ATG4B and ATG4D mediate delipidation of ATG8 proteins conjugated to PS during non-canonical autophagy (By similarity). ATG4B constitutes the major protein for proteolytic activation (By similarity). ATG4D is the main enzyme for delipidation activity (PubMed:33795848). Belongs to the ATG8 family. Sequence=BAE39576.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; autophagosome assembly autophagosome membrane mitophagy protein binding cytoplasm mitochondrion autophagosome endoplasmic reticulum Golgi apparatus cytosol cytoskeleton microtubule autophagy cellular response to nitrogen starvation microtubule binding cytoskeletal protein binding membrane macroautophagy cytoplasmic vesicle membrane Tat protein binding cytoplasmic vesicle ubiquitin protein ligase binding dendrite membrane dendrite cytoplasm cell body GABA receptor binding autophagosome maturation uc009efz.1 uc009efz.2 uc009efz.3 
ENSMUST00000032265.13 Olr1 ENSMUST00000032265.13 oxidized low density lipoprotein (lectin-like) receptor 1, transcript variant 1 (from RefSeq NM_138648.2) ENSMUST00000032265.1 ENSMUST00000032265.10 ENSMUST00000032265.11 ENSMUST00000032265.12 ENSMUST00000032265.2 ENSMUST00000032265.3 ENSMUST00000032265.4 ENSMUST00000032265.5 ENSMUST00000032265.6 ENSMUST00000032265.7 ENSMUST00000032265.8 ENSMUST00000032265.9 Lox1 NM_138648 OLR1_MOUSE Q3U3M1 Q9EQ09 uc009efw.1 uc009efw.2 uc009efw.3 uc009efw.4 Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity). Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70 (By similarity). Cell membrane ; Lipid-anchor Cell membrane ; Single-pass type II membrane protein Membrane raft Secreted Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation (By similarity). The cytoplasmic region is required for subcellular sorting on the cell surface. The C-type lectin domain mediates the recognition and binding of oxLDL. The Neck region contains 3 internal repeats that are only found in rodents. N-glycosylated. Name=Functional Glycomics Gateway - Glycan Binding; Note=Oxidised LDL receptor; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_179"; immune system process low-density lipoprotein receptor activity extracellular region nucleoplasm plasma membrane endocytosis inflammatory response cell adhesion leukocyte cell-cell adhesion cell death negative regulation of gene expression membrane integral component of membrane extrinsic component of plasma membrane carbohydrate binding lipoprotein metabolic process identical protein binding intracellular membrane-bounded organelle receptor complex membrane raft uc009efw.1 uc009efw.2 uc009efw.3 uc009efw.4 
ENSMUST00000032269.12 Rad52 ENSMUST00000032269.12 RAD52 homolog, DNA repair protein, transcript variant 4 (from RefSeq NM_011236.3) ENSMUST00000032269.1 ENSMUST00000032269.10 ENSMUST00000032269.11 ENSMUST00000032269.2 ENSMUST00000032269.3 ENSMUST00000032269.4 ENSMUST00000032269.5 ENSMUST00000032269.6 ENSMUST00000032269.7 ENSMUST00000032269.8 ENSMUST00000032269.9 G5E879 G5E879_MOUSE NM_011236 Rad52 uc009dmp.1 uc009dmp.2 uc009dmp.3 uc009dmp.4 Belongs to the RAD52 family. double-strand break repair via homologous recombination DNA recombinase assembly nucleus DNA repair DNA recombination double-strand break repair via single-strand annealing uc009dmp.1 uc009dmp.2 uc009dmp.3 uc009dmp.4 
ENSMUST00000032270.13 Klrc1 ENSMUST00000032270.13 killer cell lectin-like receptor subfamily C, member 1, transcript variant 1 (from RefSeq NM_001136068.2) ENSMUST00000032270.1 ENSMUST00000032270.10 ENSMUST00000032270.11 ENSMUST00000032270.12 ENSMUST00000032270.2 ENSMUST00000032270.3 ENSMUST00000032270.4 ENSMUST00000032270.5 ENSMUST00000032270.6 ENSMUST00000032270.7 ENSMUST00000032270.8 ENSMUST00000032270.9 Klrc1 NM_001136068 Nkg2a Q9Z202 Q9Z202_MOUSE uc009ego.1 uc009ego.2 uc009ego.3 uc009ego.4 Cell membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein external side of plasma membrane membrane integral component of membrane MHC class I protein complex binding carbohydrate binding receptor complex uc009ego.1 uc009ego.2 uc009ego.3 uc009ego.4 
ENSMUST00000032272.13 Adipor2 ENSMUST00000032272.13 adiponectin receptor 2, transcript variant 1 (from RefSeq NM_197985.4) Adipor2 D6Ucla1e ENSMUST00000032272.1 ENSMUST00000032272.10 ENSMUST00000032272.11 ENSMUST00000032272.12 ENSMUST00000032272.2 ENSMUST00000032272.3 ENSMUST00000032272.4 ENSMUST00000032272.5 ENSMUST00000032272.6 ENSMUST00000032272.7 ENSMUST00000032272.8 ENSMUST00000032272.9 NM_197985 PAQR2_MOUSE Parq2 Q8BQS5 Q8CA45 Q8CID6 uc009dme.1 uc009dme.2 uc009dme.3 Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17327425, PubMed:17068142, PubMed:17268472, PubMed:24742672). Required for normal body fat and glucose homeostasis (PubMed:17327425, PubMed:17068142, PubMed:17268472, PubMed:24742672). ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake (PubMed:12802337, PubMed:17268472, PubMed:24742672). Has intermediate affinity for globular and full-length adiponectin (PubMed:12802337). Required for normal revascularization after chronic ischemia caused by severing of blood vessels (PubMed:24742672). May form homooligomers and heterooligomers with ADIPOR1 (By similarity). Interacts with APPL2 (via BAR domain); ADIPOQ dissociates this interaction (PubMed:19661063). Cell membrane ; Multi-pass membrane protein Note=Localized to the cell membrane and intracellular organelles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BQS5-1; Sequence=Displayed; Name=2; IsoId=Q8BQS5-2; Sequence=VSP_008887, VSP_008888; Detected in liver and quadriceps muscle (at protein level) (PubMed:17327425). Highly expressed in liver (PubMed:12802337). Highly expressed in white adipose tissue, and at intermediate levels in brown adipose tissue (PubMed:24742672). Expressed at intermediate level in heart, kidney, lung and skeletal muscle. Weakly expressed in brain, spleen and testis. The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane. Mutant mice are viable and fertile, and display increased glucose tolerance (PubMed:17327425, PubMed:17068142, PubMed:17268472, PubMed:24742672). On a high fat diet, they have lower fasting insulin levels than wild-type (PubMed:17327425, PubMed:24742672). Mutant mice have lower plasma cholesterol levels on a high fat diet, and possibly also on normal chow (PubMed:17327425, PubMed:17068142). The precise phenotype may depend on the experimental details and on genotype. Male and female mutant mice are somewhat leaner than wild-type on standard chow and do not display increased weight gain on a high fat diet (PubMed:17327425, PubMed:24742672). Mutant mice have normal body weight on standard chow, but decreased weight gain on a high-fat diet (PubMed:17068142). Female mutant mice display lower total body fat than wild-type on a high fat diet (PubMed:17327425). Both male and female mice have reduced levels of white and brown adipose tissue relative to wild-type (PubMed:17327425). Mutant male mice display decreased testis weight, atrophy of the seminiferous tubules and aspermia (PubMed:17327425). Both male and female mice display increased brain weight relative to wild-type (PubMed:17327425). Mutant mice have increased locomotor activity and increased energy expenditure on a high fat diet (PubMed:17327425). Mutant mice display impaired revascularization, limb retraction, atrophy and necrosis in response to limb ischemia caused by severing the femoral artery (PubMed:24742672). Hepatocytes from mice lacking both Adipor1 and Adipor2 show loss of adiponectin binding and lack of adiponectin-mediated activation of AMPK and Ppara (PubMed:17268472). Mice lacking both Adipor1 and Adipor2 display elevated glucose and insulin levels in blood plasma, indicative of glucose intolerance and insulin resistance (PubMed:17268472). Belongs to the ADIPOR family. protein binding plasma membrane lipid metabolic process fatty acid metabolic process heart development female pregnancy response to nutrient hormone-mediated signaling pathway membrane integral component of membrane fatty acid oxidation negative regulation of cell growth intrinsic component of plasma membrane adiponectin-activated signaling pathway signaling receptor activity glucose homeostasis identical protein binding positive regulation of glucose import metal ion binding protein heterodimerization activity adiponectin binding vascular wound healing adipokinetic hormone receptor activity uc009dme.1 uc009dme.2 uc009dme.3 
ENSMUST00000032283.12 Ccdc77 ENSMUST00000032283.12 coiled-coil domain containing 77, transcript variant 1 (from RefSeq NM_026028.5) CCD77_MOUSE ENSMUST00000032283.1 ENSMUST00000032283.10 ENSMUST00000032283.11 ENSMUST00000032283.2 ENSMUST00000032283.3 ENSMUST00000032283.4 ENSMUST00000032283.5 ENSMUST00000032283.6 ENSMUST00000032283.7 ENSMUST00000032283.8 ENSMUST00000032283.9 NM_026028 Q8VEJ7 Q9CZH8 uc009dmz.1 uc009dmz.2 uc009dmz.3 uc009dmz.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZH8-1; Sequence=Displayed; Name=2; IsoId=Q9CZH8-2; Sequence=VSP_022264; molecular_function centrosome biological_process uc009dmz.1 uc009dmz.2 uc009dmz.3 uc009dmz.4 
ENSMUST00000032288.6 Klra1 ENSMUST00000032288.6 killer cell lectin-like receptor, subfamily A, member 1 (from RefSeq NM_016659.3) ENSMUST00000032288.1 ENSMUST00000032288.2 ENSMUST00000032288.3 ENSMUST00000032288.4 ENSMUST00000032288.5 Klra1 NM_016659 Q8BNV4 Q8MHR8 Q8MHR8_MOUSE uc009ein.1 uc009ein.2 uc009ein.3 membrane integral component of membrane carbohydrate binding uc009ein.1 uc009ein.2 uc009ein.3 
ENSMUST00000032306.15 Klra2 ENSMUST00000032306.15 killer cell lectin-like receptor, subfamily A, member 2, transcript variant 2 (from RefSeq NM_008462.6) ENSMUST00000032306.1 ENSMUST00000032306.10 ENSMUST00000032306.11 ENSMUST00000032306.12 ENSMUST00000032306.13 ENSMUST00000032306.14 ENSMUST00000032306.2 ENSMUST00000032306.3 ENSMUST00000032306.4 ENSMUST00000032306.5 ENSMUST00000032306.6 ENSMUST00000032306.7 ENSMUST00000032306.8 ENSMUST00000032306.9 Klra2 NM_008462 Q9D3R1 Q9D3R1_MOUSE uc009eip.1 uc009eip.2 uc009eip.3 The gene is a member of the large lectin-like type 2 transmembrane receptor family of the natural killer gene complex. The gene is located distantly telomeric to its family's gene cluster on chromosome 6. The gene differs from the other genes in its cluster as its promoter region contains long and short interspersed repetitive elements suggesting a possible rearrangement or gene conversion. It is unknown whether this gene's encoded protein is involved with natural killer cell differentiation as are its other family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. membrane integral component of membrane carbohydrate binding uc009eip.1 uc009eip.2 uc009eip.3 
ENSMUST00000032307.12 Magohb ENSMUST00000032307.12 mago homolog B, exon junction complex core component, transcript variant 1 (from RefSeq NM_025564.2) A0A023T778 A0A023T778_MOUSE ENSMUST00000032307.1 ENSMUST00000032307.10 ENSMUST00000032307.11 ENSMUST00000032307.2 ENSMUST00000032307.3 ENSMUST00000032307.4 ENSMUST00000032307.5 ENSMUST00000032307.6 ENSMUST00000032307.7 ENSMUST00000032307.8 ENSMUST00000032307.9 Magohb NM_025564 uc009eiq.1 uc009eiq.2 uc009eiq.3 Nucleus Belongs to the mago nashi family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA splicing, via spliceosome nucleus RNA splicing exon-exon junction complex neuronal cell body U2-type precatalytic spliceosome U2-type catalytic step 1 spliceosome uc009eiq.1 uc009eiq.2 uc009eiq.3 
ENSMUST00000032309.13 Ybx3 ENSMUST00000032309.13 Y box protein 3, transcript variant 1 (from RefSeq NM_139117.2) Csda ENSMUST00000032309.1 ENSMUST00000032309.10 ENSMUST00000032309.11 ENSMUST00000032309.12 ENSMUST00000032309.2 ENSMUST00000032309.3 ENSMUST00000032309.4 ENSMUST00000032309.5 ENSMUST00000032309.6 ENSMUST00000032309.7 ENSMUST00000032309.8 ENSMUST00000032309.9 Msy4 NM_139117 Q80WG4 Q9EQF7 Q9EQF8 Q9JKB3 YBOX3_MOUSE uc009eis.1 uc009eis.2 uc009eis.3 Binds to the GM-CSF promoter. Seems to act as a repressor (By similarity). Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression. Found in a mRNP complex with YBX2 (PubMed:10772793). Interacts with RRP1B (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Msy3l; IsoId=Q9JKB3-1; Sequence=Displayed; Name=2; Synonyms=Msy3s; IsoId=Q9JKB3-2; Sequence=VSP_013051; Expressed in oocytes, spermatocytes and spermatids (at protein level). Expressed in skeletal muscle, kidney, brain, spleen, liver, heart and spermatids. Isoform 2 is preferentially expressed in somatic tissues (PubMed:10956549). Transgenic mice overexpressing Ybx3 exhibit disruption of the normal completion of spermatogenesis, dominant sterility and abnormal translation activation of repressed mRNA. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development nucleic acid binding DNA binding single-stranded DNA binding RNA binding mRNA 3'-UTR binding protein binding nucleus cytoplasm cytosol gap junction spermatogenesis male gonad development fertilization negative regulation of apoptotic process positive regulation of organ growth negative regulation of skeletal muscle tissue development negative regulation of necroptotic process cellular response to tumor necrosis factor cellular hyperosmotic response negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress polysome binding uc009eis.1 uc009eis.2 uc009eis.3 
ENSMUST00000032315.3 Tas2r116 ENSMUST00000032315.3 taste receptor, type 2, member 116 (from RefSeq NM_053212.1) ENSMUST00000032315.1 ENSMUST00000032315.2 NM_053212 Q7M713 Q9JKA1 Q9JKA4 T2r56 TR116_MOUSE Tas2r116 uc009ejr.1 uc009ejr.2 Putative taste receptor which may play a role in the perception of bitterness. Membrane ; Multi-pass membrane protein Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009ejr.1 uc009ejr.2 
ENSMUST00000032317.4 Tas2r103 ENSMUST00000032317.4 taste receptor, type 2, member 103 (from RefSeq NM_053211.1) ENSMUST00000032317.1 ENSMUST00000032317.2 ENSMUST00000032317.3 NM_053211 Q7M706 Q9JKA3 TR103_MOUSE Tas2r10 uc012eug.1 uc012eug.2 Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Membrane; Multi-pass membrane protein. Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc012eug.1 uc012eug.2 
ENSMUST00000032321.11 Bcl2l14 ENSMUST00000032321.11 BCL2 like 14, transcript variant 1 (from RefSeq NM_025778.3) B2L14_MOUSE ENSMUST00000032321.1 ENSMUST00000032321.10 ENSMUST00000032321.2 ENSMUST00000032321.3 ENSMUST00000032321.4 ENSMUST00000032321.5 ENSMUST00000032321.6 ENSMUST00000032321.7 ENSMUST00000032321.8 ENSMUST00000032321.9 NM_025778 Q3TVA7 Q8R141 Q9CPT0 Q9D3W3 uc009ekh.1 uc009ekh.2 uc009ekh.3 Plays a role in apoptosis. Q9CPT0; P62862: Fau; NbExp=4; IntAct=EBI-8296066, EBI-309546; Cytoplasm Phosphorylated by MELK, leading to inhibit its pro-apoptotic function. Belongs to the Bcl-2 family. protein binding cytoplasm cytosol apoptotic process protein kinase binding regulation of apoptotic process intracellular organelle positive regulation of extrinsic apoptotic signaling pathway uc009ekh.1 uc009ekh.2 uc009ekh.3 
ENSMUST00000032322.15 Lrp6 ENSMUST00000032322.15 low density lipoprotein receptor-related protein 6 (from RefSeq NM_008514.4) A0A0R4J0A9 A0A0R4J0A9_MOUSE ENSMUST00000032322.1 ENSMUST00000032322.10 ENSMUST00000032322.11 ENSMUST00000032322.12 ENSMUST00000032322.13 ENSMUST00000032322.14 ENSMUST00000032322.2 ENSMUST00000032322.3 ENSMUST00000032322.4 ENSMUST00000032322.5 ENSMUST00000032322.6 ENSMUST00000032322.7 ENSMUST00000032322.8 ENSMUST00000032322.9 Lrp6 NM_008514 uc009ekl.1 uc009ekl.2 uc009ekl.3 uc009ekl.4 Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling. Membrane ; Single- pass type I membrane protein Belongs to the LDLR family. Lacks conserved residue(s) required for the propagation of feature annotation. negative regulation of protein phosphorylation low-density lipoprotein receptor activity receptor binding frizzled binding early endosome Golgi apparatus plasma membrane caveola regulation of transcription, DNA-templated negative regulation of protein kinase activity endocytosis positive regulation of cytosolic calcium ion concentration chemical synaptic transmission multicellular organism development cell surface neural crest formation neural crest cell differentiation membrane integral component of membrane Wnt signaling pathway Wnt-protein binding kinase inhibitor activity toxin transporter activity cytoplasmic vesicle negative regulation of smooth muscle cell apoptotic process identical protein binding protein homodimerization activity Wnt-activated receptor activity neuronal cell body response to peptide hormone synapse positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity canonical Wnt signaling pathway cellular response to cholesterol negative regulation of protein serine/threonine kinase activity coreceptor activity involved in Wnt signaling pathway protein localization to plasma membrane cell-cell adhesion toxin transport Wnt-Frizzled-LRP5/6 complex Wnt signalosome uc009ekl.1 uc009ekl.2 uc009ekl.3 uc009ekl.4 
ENSMUST00000032326.11 Ddx47 ENSMUST00000032326.11 DEAD box helicase 47 (from RefSeq NM_026360.3) DDX47_MOUSE ENSMUST00000032326.1 ENSMUST00000032326.10 ENSMUST00000032326.2 ENSMUST00000032326.3 ENSMUST00000032326.4 ENSMUST00000032326.5 ENSMUST00000032326.6 ENSMUST00000032326.7 ENSMUST00000032326.8 ENSMUST00000032326.9 NM_026360 Q9CWX9 uc009eld.1 uc009eld.2 uc009eld.3 Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Interacts with AGO1 and AGO2. Interacts with GABARAP. Interacts with NOL8; the interaction is RNA-dependent (By similarity). Nucleus, nucleolus Note=Localizes in the nucleolar-organizing region during ribosome biogenesis. Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus nucleolus rRNA processing mRNA processing apoptotic process RNA splicing extrinsic apoptotic signaling pathway via death domain receptors hydrolase activity uc009eld.1 uc009eld.2 uc009eld.3 
ENSMUST00000032335.13 Atf7ip ENSMUST00000032335.13 activating transcription factor 7 interacting protein, transcript variant 3 (from RefSeq NM_019426.3) ENSMUST00000032335.1 ENSMUST00000032335.10 ENSMUST00000032335.11 ENSMUST00000032335.12 ENSMUST00000032335.2 ENSMUST00000032335.3 ENSMUST00000032335.4 ENSMUST00000032335.5 ENSMUST00000032335.6 ENSMUST00000032335.7 ENSMUST00000032335.8 ENSMUST00000032335.9 MCAF1_MOUSE Mcaf1 NM_019426 Q3TJ86 Q3TZW1 Q3UVK5 Q3UYZ7 Q7TT18 Q80ZK7 Q8C4A1 Q9JK31 uc009elv.1 uc009elv.2 uc009elv.3 Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context (PubMed:10777215). Required for HUSH-mediated heterochromatin formation and gene silencing (By similarity). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (By similarity). Interacts with MBD1; the interaction is enhanced when MBD1 is sumoylated (By similarity). Interacts with SETDB1; the interaction protects SETDB1 from proteasomal degradation and is required to stimulate histone methyltransferase activity and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (PubMed:14536086). Interacts with SUMO ubiquitin-like proteins (SUMO1, SUNO2 and SUMO3), with a preference for SUMO2 and SUMO3. Interacts with SP1, ATF7 and ZHX1. Interacts with the general transcription machinery, including ERCC2, ERCC3, GTF2E1, GTF2E2 and POLR2A (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TT18-1; Sequence=Displayed; Name=2; IsoId=Q7TT18-2; Sequence=VSP_024040, VSP_024041; Ubiquitously expressed at all stages studied. Belongs to the MCAF family. Sequence=BAE39609.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter transcription corepressor activity nucleus nucleoplasm transcription factor complex cytosol DNA methylation nuclear body ATPase activity regulation of protein stability negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of RNA polymerase II transcriptional preinitiation complex assembly protein stabilization positive regulation of methylation-dependent chromatin silencing uc009elv.1 uc009elv.2 uc009elv.3 
ENSMUST00000032336.7 Plbd1 ENSMUST00000032336.7 phospholipase B domain containing 1 (from RefSeq NM_025806.2) A0A0R4J0B2 A0A0R4J0B2_MOUSE ENSMUST00000032336.1 ENSMUST00000032336.2 ENSMUST00000032336.3 ENSMUST00000032336.4 ENSMUST00000032336.5 ENSMUST00000032336.6 NM_025806 Plbd1 uc009elz.1 uc009elz.2 uc009elz.3 uc009elz.4 Putative phospholipase. Belongs to the phospholipase B-like family. phospholipase activity extracellular space lipid metabolic process lipid catabolic process hydrolase activity uc009elz.1 uc009elz.2 uc009elz.3 uc009elz.4 
ENSMUST00000032338.10 Gucy2c ENSMUST00000032338.10 guanylate cyclase 2c, transcript variant 1 (from RefSeq NM_001127318.1) ENSMUST00000032338.1 ENSMUST00000032338.2 ENSMUST00000032338.3 ENSMUST00000032338.4 ENSMUST00000032338.5 ENSMUST00000032338.6 ENSMUST00000032338.7 ENSMUST00000032338.8 ENSMUST00000032338.9 GUC2C_MOUSE Guc2c NM_001127318 Q3UWA6 Q499D2 Q8JZQ6 uc009emc.1 uc009emc.2 uc009emc.3 uc009emc.4 Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13666; Evidence=; Homotrimer. Interacts via its C-terminal region with NHERF4. Interacts with the lectin chaperone VIP36. Cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single- pass type I membrane protein Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UWA6-1; Sequence=Displayed; Name=2; IsoId=Q3UWA6-2; Sequence=VSP_023652; The protein kinase domain is predicted to be catalytically inactive. Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand- mediated GC-C activation. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding peptide receptor activity guanylate cyclase activity protein kinase activity ATP binding GTP binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane cGMP biosynthetic process protein phosphorylation signal transduction receptor guanylyl cyclase signaling pathway cyclic nucleotide biosynthetic process response to toxic substance toxic substance binding membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity natriuretic peptide receptor activity peptide hormone binding intracellular signal transduction regulation of cell proliferation uc009emc.1 uc009emc.2 uc009emc.3 uc009emc.4 
ENSMUST00000032341.3 Art4 ENSMUST00000032341.3 ADP-ribosyltransferase 4 (from RefSeq NM_026639.2) ENSMUST00000032341.1 ENSMUST00000032341.2 NAR4_MOUSE NM_026639 Q80VB5 Q80W56 Q9CRA0 uc009emk.1 uc009emk.2 uc009emk.3 Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D- ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=2.4.2.31; Membrane ; Single-pass type I membrane protein Cell membrane ; Lipid- anchor, GPI-anchor Belongs to the Arg-specific ADP-ribosyltransferase family. NAD+ ADP-ribosyltransferase activity NAD(P)+-protein-arginine ADP-ribosyltransferase activity cellular_component plasma membrane protein ADP-ribosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups peptidyl-arginine ADP-ribosylation anchored component of membrane uc009emk.1 uc009emk.2 uc009emk.3 
ENSMUST00000032342.3 Mgp ENSMUST00000032342.3 matrix Gla protein (from RefSeq NM_008597.4) ENSMUST00000032342.1 ENSMUST00000032342.2 MGP_MOUSE Mglap NM_008597 P19788 Q6LD77 Q8JZW0 uc009eml.1 uc009eml.2 uc009eml.3 This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. This protein also inhibits angiogenesis. Mice lacking a functional copy of this gene exhibit impaired differentiation of endothelial cells, reduced stature, and calcification and rupture of the vasculature leading to premature death. [provided by RefSeq, Sep 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY702829.1, EL964633.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. Secreted. Requires vitamin K-dependent gamma-carboxylation for its function. Belongs to the osteocalcin/matrix Gla protein family. ossification calcium ion binding extracellular region extracellular space endoplasmic reticulum multicellular organism development cell differentiation lung development regulation of bone mineralization extracellular matrix macromolecular complex calcium-dependent protein binding branching morphogenesis of an epithelial tube cartilage development macromolecular complex assembly uc009eml.1 uc009eml.2 uc009eml.3 
ENSMUST00000032343.7 Erp27 ENSMUST00000032343.7 endoplasmic reticulum protein 27, transcript variant 1 (from RefSeq NM_026983.2) ENSMUST00000032343.1 ENSMUST00000032343.2 ENSMUST00000032343.3 ENSMUST00000032343.4 ENSMUST00000032343.5 ENSMUST00000032343.6 ERP27_MOUSE NM_026983 Q3SX97 Q9D8U3 uc009emm.1 uc009emm.2 uc009emm.3 Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates. Binds protein substrates via a hydrophobic pocket in the C-terminal domain. May play a role in the unfolded stress response. Interacts with PDIA3. Endoplasmic reticulum lumen Belongs to the protein disulfide isomerase family. Does not contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family. endoplasmic reticulum endoplasmic reticulum lumen protein folding cell surface response to endoplasmic reticulum stress protein disulfide isomerase activity uc009emm.1 uc009emm.2 uc009emm.3 
ENSMUST00000032344.12 Arhgdib ENSMUST00000032344.12 Rho, GDP dissociation inhibitor beta, transcript variant 1 (from RefSeq NM_007486.6) ENSMUST00000032344.1 ENSMUST00000032344.10 ENSMUST00000032344.11 ENSMUST00000032344.2 ENSMUST00000032344.3 ENSMUST00000032344.4 ENSMUST00000032344.5 ENSMUST00000032344.6 ENSMUST00000032344.7 ENSMUST00000032344.8 ENSMUST00000032344.9 GDIR2_MOUSE Gdid4 NM_007486 Q3TEB3 Q61599 uc009emp.1 uc009emp.2 uc009emp.3 uc009emp.4 uc009emp.5 The protein encoded by this gene is a member of the Rho guanine nucleotide dissociation inhibitor (GDI) family. This gene is expressed at high levels in hematopoietic cells. This protein is cytosolic, and dissociation of Rho from this protein is required for membrane association and activation of Rho by Guanine Nucleotide Exchange Factors (GEFs). C-terminal truncations of this gene product have been reported to promote metastasis. Multiple transcript variants and protein isoforms exist. [provided by RefSeq, Aug 2014]. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members. Interacts with RHOA. Interacts with RAC1. Interacts with RAC2. Interacts with CDC42. Cytoplasm, cytosol Preferentially expressed in hematopoietic cells. Belongs to the Rho GDI family. GTPase activity Rho GDP-dissociation inhibitor activity GTPase activator activity cytoplasm cytosol Rho protein signal transduction membrane regulation of Rho protein signal transduction positive regulation of GTPase activity Rac GTPase binding regulation of catalytic activity cellular response to redox state negative regulation of trophoblast cell migration regulation of actin cytoskeleton reorganization uc009emp.1 uc009emp.2 uc009emp.3 uc009emp.4 uc009emp.5 
ENSMUST00000032347.11 Rerg ENSMUST00000032347.11 RAS-like, estrogen-regulated, growth-inhibitor, transcript variant 2 (from RefSeq NM_181988.2) ENSMUST00000032347.1 ENSMUST00000032347.10 ENSMUST00000032347.2 ENSMUST00000032347.3 ENSMUST00000032347.4 ENSMUST00000032347.5 ENSMUST00000032347.6 ENSMUST00000032347.7 ENSMUST00000032347.8 ENSMUST00000032347.9 NM_181988 Q8R367 RERG_MOUSE uc009ems.1 uc009ems.2 uc009ems.3 uc009ems.4 Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Cytoplasm Belongs to the small GTPase superfamily. Ras family. nucleotide binding GTPase activity GTP binding nucleus cytoplasm cytosol plasma membrane signal transduction Ras protein signal transduction negative regulation of cell proliferation response to hormone membrane GDP binding negative regulation of cell growth uc009ems.1 uc009ems.2 uc009ems.3 uc009ems.4 
ENSMUST00000032356.13 Plcz1 ENSMUST00000032356.13 phospholipase C, zeta 1 (from RefSeq NM_054066.4) ENSMUST00000032356.1 ENSMUST00000032356.10 ENSMUST00000032356.11 ENSMUST00000032356.12 ENSMUST00000032356.2 ENSMUST00000032356.3 ENSMUST00000032356.4 ENSMUST00000032356.5 ENSMUST00000032356.6 ENSMUST00000032356.7 ENSMUST00000032356.8 ENSMUST00000032356.9 NM_054066 PLCZ1_MOUSE Plcz1 Q3KPE5 Q8K4D7 uc033ivu.1 uc033ivu.2 uc033ivu.3 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33180; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro. Nucleus toplasm, perinuclear region Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronuclei at interphase following meiosis and mitosis. Event=Alternative splicing; Named isoforms=2; Name=1 IsoId=Q8K4D7-1; Sequence=Displayed; Name=2 ; IsoId=Q8K4D7-2; Sequence=VSP_052863; Highly expressed in postpuberal testis, where expression is sperm cell-specific. Also expressed in brain of both sexes. The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity. The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization. Transgenic mice, where broad ectopic expression is forced, initially appear healthy and their oocytes undergo unperturbed meiotic maturation to metaphase II but subsequently exhibit autonomous intracellular free calcium oscillations, second polar body extrusion, pronucleus formation and parthenogenetic development. Transgenic males remained largely asymptomatic, whereas transgenic females develop abdominal swellings caused by benign ovarian teratomas. phosphatidylinositol phospholipase C activity phospholipase C activity calcium ion binding phosphatidylinositol-4,5-bisphosphate binding nucleus nucleoplasm nucleolus cytoplasm cytosol lipid metabolic process calcium ion transport signal transduction positive regulation of cytosolic calcium ion concentration multicellular organism development single fertilization egg activation phosphoric diester hydrolase activity phosphatidylinositol-5-phosphate binding lipid catabolic process hydrolase activity phosphatidylinositol-3-phosphate binding inositol trisphosphate biosynthetic process intracellular signal transduction pronucleus phosphatidylinositol-mediated signaling perinuclear region of cytoplasm release of sequestered calcium ion into cytosol positive regulation of cytosolic calcium ion concentration involved in egg activation uc033ivu.1 uc033ivu.2 uc033ivu.3 
ENSMUST00000032359.15 Aebp2 ENSMUST00000032359.15 AE binding protein 2, transcript variant 2 (from RefSeq NM_178803.3) AEBP2_MOUSE ENSMUST00000032359.1 ENSMUST00000032359.10 ENSMUST00000032359.11 ENSMUST00000032359.12 ENSMUST00000032359.13 ENSMUST00000032359.14 ENSMUST00000032359.2 ENSMUST00000032359.3 ENSMUST00000032359.4 ENSMUST00000032359.5 ENSMUST00000032359.6 ENSMUST00000032359.7 ENSMUST00000032359.8 ENSMUST00000032359.9 NM_178803 Q6PF91 Q78HB0 Q8BGV1 Q8CE51 Q9Z248 uc009eoi.1 uc009eoi.2 Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex. Self-associates (By similarity). Associates with the PRC2 complex, which consists of the core components EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:19026780, PubMed:20144788). Found in a monomeric PRC2.2 (class 2) complex consisting of at least SUZ12, RBBP4, AEBP2 and JARID2 (By similarity). Within the PRC2 complex, interacts directly with SUZ12; competes with PHF19 for SUZ12 binding (By similarity). Interacts with EED, EZH2, and RBBP4 (By similarity). May also interact with RBBP7 (By similarity). Nucleus Note=Localizes to chromatin as part of the PRC2 complex. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9Z248-1; Sequence=Displayed; Name=2; IsoId=Q9Z248-2; Sequence=VSP_034362; Name=3; IsoId=Q9Z248-3; Sequence=VSP_034360, VSP_034363; Name=4; IsoId=Q9Z248-4; Sequence=VSP_034360, VSP_034362; Name=5; IsoId=Q9Z248-5; Sequence=VSP_034361, VSP_034362; Expressed in brain, brown adipose tissue, white adipose tissue, heart, kidney, lung, skeletal muscle, small intestine and spleen. Expressed at low levels in liver. Belongs to the AEBP2/jing C2H2-type zinc-finger family. Sequence=AAD02854.1; Type=Frameshift; Evidence=; Sequence=BAC32508.1; Type=Frameshift; Evidence=; Sequence=BAC32562.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription corepressor activity nucleus chromatin organization regulation of transcription, DNA-templated ESC/E(Z) complex metal ion binding uc009eoi.1 uc009eoi.2 
ENSMUST00000032362.12 Slco1c1 ENSMUST00000032362.12 solute carrier organic anion transporter family, member 1c1, transcript variant 3 (from RefSeq NR_149743.1) ENSMUST00000032362.1 ENSMUST00000032362.10 ENSMUST00000032362.11 ENSMUST00000032362.2 ENSMUST00000032362.3 ENSMUST00000032362.4 ENSMUST00000032362.5 ENSMUST00000032362.6 ENSMUST00000032362.7 ENSMUST00000032362.8 ENSMUST00000032362.9 NR_149743 Oatp1c1 Oatpf Q8BX54 Q9ERB5 SO1C1_MOUSE Slc21a14 uc009eop.1 uc009eop.2 uc009eop.3 Mediates the Na(+)-independent high affinity transport of thyroid hormones at the plasma membrane of brain capillary endothelial cells (PubMed:15166123, PubMed:24691440, PubMed:22294745). The transport activity of substrates L-thyroxine (T4) and 3,3',5'-triiodo- L-thyronine (reverse T3, rT3) is much greater than that of 3,3',5- triiodo-L-thyronine (T3) (PubMed:15166123). The prehormone, T4, is the major form in the circulating blood and is converted to the active form, T3, by the iodothyronine-deiodinase in peripheral organs (PubMed:15166123). T3 plays an essential role in brain development via binding to specific nuclear receptors (thyroid hormone receptor) (PubMed:15166123, PubMed:22294745). Also transports organic anions such as the conjugated steroid 17-beta-glucuronosyl estradiol (17beta- estradiol 17-O-(beta-D-glucuronate)) (PubMed:15166123). Transports T4 and estrone-3-sulfate in a pH-insensitive manner (By similarity). May serve as a drug efflux system at the blood brain barrier (By similarity). Reaction=3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L- thyronine(in); Xref=Rhea:RHEA:71815, ChEBI:CHEBI:57261; Evidence=; Reaction=L-thyroxine(out) = L-thyroxine(in); Xref=Rhea:RHEA:71819, ChEBI:CHEBI:58448; Evidence= Reaction=L-thyroxine sulfate(out) = L-thyroxine sulfate(in); Xref=Rhea:RHEA:73311, ChEBI:CHEBI:176512; Evidence=; Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(out) = 17beta- estradiol 17-O-(beta-D-glucuronate)(in); Xref=Rhea:RHEA:72691, ChEBI:CHEBI:82961; Evidence=; Reaction=3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L- thyronine(in); Xref=Rhea:RHEA:71811, ChEBI:CHEBI:533015; Evidence=; Kinetic parameters: KM=0.34 uM for L-thyroxine ; KM=0.46 uM for 3,3',5'-triiodo-L-thyronine ; KM=23.5 uM for 17beta-estradiol 17-O-(beta-D-glucuronate) ; Vmax=11.7 pmol/min/mg protein with L-thyroxine ; Vmax=25.5 pmol/min/mg protein with 3,3',5'-triiodo-L-thyronine ; Vmax=95.8 pmol/min/mg protein with 17beta-estradiol 17-O-(beta-D- glucuronate) ; Cell membrane ulti-pass membrane protein Note=Expressed at the basolateral membrane of the choroid plexus epithelial cells. Widely expressed throughout the brain except in the cerebellum (PubMed:15166123). Not detected in kidney, heart, lung, skeletal muscle, spleen, liver, nor testis (PubMed:15166123). Highly expressed in cerebral microvessels throughout the brain and in the choroid plexus (at mRNA and protein level) (PubMed:15166123, PubMed:18687783, PubMed:22294745). Knockout mice present a general hypothyroidal state of the CNS, with reduced levels of both T3 and T4, and increased activity of the iodothyronine-deiodinase D2. Belongs to the organo anion transporter (TC 2.A.60) family. plasma membrane integral component of plasma membrane ion transport organic anion transmembrane transporter activity bile acid transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity thyroid hormone transmembrane transporter activity organic anion transport bile acid and bile salt transport membrane integral component of membrane sodium-independent organic anion transport transmembrane transport thyroid hormone transport uc009eop.1 uc009eop.2 uc009eop.3 
ENSMUST00000032371.8 Gys2 ENSMUST00000032371.8 glycogen synthase 2, transcript variant 1 (from RefSeq NM_145572.3) ENSMUST00000032371.1 ENSMUST00000032371.2 ENSMUST00000032371.3 ENSMUST00000032371.4 ENSMUST00000032371.5 ENSMUST00000032371.6 ENSMUST00000032371.7 GYS2_MOUSE Gys2 NM_145572 Q3UTY0 Q8VCB3 uc009epi.1 uc009epi.2 uc009epi.3 Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Reaction=[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)- alpha-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:18549, Rhea:RHEA- COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18550; Evidence=; Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6- phosphate as an allosteric activator; when phosphorylated it does (By similarity). Kinetic parameters: KM=0.48 mM for UDP-glucose (at 30 degrees Celsius) ; Glycan biosynthesis; glycogen biosynthesis. Part of the glycogen synthase (GS)-glycogenin complex, a heterooctamer composed of a tetramer of GS and 2 dimers of glycogenin, where each GS protomer binds to one glycogenin subunit (via glycogenin C-terminus); the GS tetramer may dissociate from glycogenin dimers to continue glycogen polymerization on its own (By similarity). May also form a heterooctamer complex with GYG1 (via GYG1 C-terminus) (Probable). Specifically expressed in liver. Expression in the liver oscillates in a circadian manner with peak levels during the night. Phosphorylation reduces the activity towards UDP-alpha-D-glucose (By similarity). Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme (By similarity). Phosphorylation at Ser-8 is not required for interaction with GYG1 (PubMed:24982189). Interaction with GYG1 does not regulate the phosphorylation at Ser-8 and Ser-641 (PubMed:24982189). Belongs to the glycosyltransferase 3 family. catalytic activity glycogen (starch) synthase activity glucose binding cytoplasm cytosol cytoskeleton cell cortex glycogen metabolic process glycogen biosynthetic process metabolic process response to glucose transferase activity transferase activity, transferring glycosyl groups cortical actin cytoskeleton ectoplasm uc009epi.1 uc009epi.2 uc009epi.3 
ENSMUST00000032372.7 Golt1b ENSMUST00000032372.7 golgi transport 1B, transcript variant 3 (from RefSeq NM_025872.5) ENSMUST00000032372.1 ENSMUST00000032372.2 ENSMUST00000032372.3 ENSMUST00000032372.4 ENSMUST00000032372.5 ENSMUST00000032372.6 GOT1B_MOUSE NM_025872 Q9CR60 uc009epg.1 uc009epg.2 uc009epg.3 May be involved in fusion of ER-derived transport vesicles with the Golgi complex. Golgi apparatus membrane ; Multi- pass membrane protein Belongs to the GOT1 family. Sequence=BAB31257.2; Type=Erroneous initiation; Evidence=; Golgi membrane endoplasmic reticulum Golgi apparatus protein transport membrane integral component of membrane vesicle-mediated transport macromolecular complex uc009epg.1 uc009epg.2 uc009epg.3 
ENSMUST00000032373.12 Ldhb ENSMUST00000032373.12 lactate dehydrogenase B, transcript variant 1 (from RefSeq NM_008492.3) ENSMUST00000032373.1 ENSMUST00000032373.10 ENSMUST00000032373.11 ENSMUST00000032373.2 ENSMUST00000032373.3 ENSMUST00000032373.4 ENSMUST00000032373.5 ENSMUST00000032373.6 ENSMUST00000032373.7 ENSMUST00000032373.8 ENSMUST00000032373.9 LDHB_MOUSE Ldh-2 Ldh2 NM_008492 P16125 Q545Y4 uc009epj.1 uc009epj.2 uc009epj.3 This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have also been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes 1 and 19. [provided by RefSeq, Feb 2016]. Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate; Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23445; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:23446; Evidence=; Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. Homotetramer. Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria. Cytoplasm. Mitochondrion inner membrane ; Peripheral membrane protein Belongs to the LDH/MDH superfamily. LDH family. catalytic activity lactate dehydrogenase activity L-lactate dehydrogenase activity cytoplasm mitochondrion cytosol carbohydrate metabolic process lactate metabolic process oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor lactate biosynthetic process from pyruvate NAD metabolic process carboxylic acid metabolic process kinase binding identical protein binding myelin sheath membrane raft NAD binding oxidation-reduction process uc009epj.1 uc009epj.2 uc009epj.3 
ENSMUST00000032376.6 Lmcd1 ENSMUST00000032376.6 LIM and cysteine-rich domains 1 (from RefSeq NM_144799.3) ENSMUST00000032376.1 ENSMUST00000032376.2 ENSMUST00000032376.3 ENSMUST00000032376.4 ENSMUST00000032376.5 LMCD1_MOUSE NM_144799 Q8VEE1 uc009ddv.1 uc009ddv.2 uc009ddv.3 uc009ddv.4 Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6- mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. Interacts with beta-dystroglycan (By similarity). Interacts with GATA1, GATA4 and GATA6. Cytoplasm Nucleus Note=May shuttle between the cytoplasm and the nucleus. Expressed in distal airway epithelium of the lung, vascular smooth muscle, and myocardium. At 9.5 dpc expressed in the myocardium and forming anterior foregut epithelium. By 12.5 dpc, expression is observed in the airways of the developing lung as well as in the myocardium. At 14.5 dpc, when proximal-distal differentiation in the lung is proceeding rapidly, expression is observed at high levels in the distal but not proximal airways of the developing lung. By 16.5 dpc, expression decreases in airway epithelium in the lung and expression is also observed in the vascular smooth muscle of pulmonary arteries (at protein level). The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6. Mice display a marked increase in cardiac hypertrophy. negative regulation of transcription from RNA polymerase II promoter transcription corepressor activity protein binding nucleus cytoplasm zinc ion binding regulation of cardiac muscle hypertrophy metal ion binding positive regulation of calcineurin-NFAT signaling cascade uc009ddv.1 uc009ddv.2 uc009ddv.3 uc009ddv.4 
ENSMUST00000032383.14 Sspn ENSMUST00000032383.14 sarcospan, transcript variant 1 (from RefSeq NM_010656.3) ENSMUST00000032383.1 ENSMUST00000032383.10 ENSMUST00000032383.11 ENSMUST00000032383.12 ENSMUST00000032383.13 ENSMUST00000032383.2 ENSMUST00000032383.3 ENSMUST00000032383.4 ENSMUST00000032383.5 ENSMUST00000032383.6 ENSMUST00000032383.7 ENSMUST00000032383.8 ENSMUST00000032383.9 NM_010656 Q3TRE0 Q3TRE0_MOUSE Sspn uc009eru.1 uc009eru.2 uc009eru.3 integral component of plasma membrane dystrophin-associated glycoprotein complex membrane integral component of membrane transport vesicle uc009eru.1 uc009eru.2 uc009eru.3 
ENSMUST00000032386.11 Bhlhe41 ENSMUST00000032386.11 basic helix-loop-helix family, member e41, transcript variant 1 (from RefSeq NM_024469.2) BHE41_MOUSE Bhlhb3 Dec2 ENSMUST00000032386.1 ENSMUST00000032386.10 ENSMUST00000032386.2 ENSMUST00000032386.3 ENSMUST00000032386.4 ENSMUST00000032386.5 ENSMUST00000032386.6 ENSMUST00000032386.7 ENSMUST00000032386.8 ENSMUST00000032386.9 NM_024469 Q99PV5 uc009ert.1 uc009ert.2 uc009ert.3 uc009ert.4 This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2014]. Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 and CYP3A11 (PubMed:30555544). Homodimer (PubMed:15560782). Heterodimer with BHLHE40/DEC1 (PubMed:15560782). Interacts with CIART (PubMed:24736997). Interacts with BMAL1 (PubMed:12397359). Interacts with RXRA (By similarity). Interacts with NR0B2 and HNF1A (PubMed:30555544). Q99PV5; P28033: Cebpb; NbExp=5; IntAct=EBI-6143801, EBI-1029979; Q99PV5; Q3TQ03: Ciart; NbExp=2; IntAct=EBI-6143801, EBI-16101489; Q99PV5; Q16665: HIF1A; Xeno; NbExp=3; IntAct=EBI-6143801, EBI-447269; Q99PV5; P25789: PSMA4; Xeno; NbExp=2; IntAct=EBI-6143801, EBI-359310; Nucleus Expressed in skeletal muscle, brain and lung. Expressed in a circdadian manner in the liver with a peak at ZT10. Activity profiles and sleep recordings of transgenic mice carrying the mutation Arg-325 show increased vigilance time and less sleep time than control mice in a zeitgeber time- and sleep deprivation-dependent manner. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription corepressor activity protein binding nucleus nucleoplasm regulation of transcription, DNA-templated circadian rhythm anterior/posterior pattern specification negative regulation of myotube differentiation negative regulation of transcription by competitive promoter binding transcriptional repressor complex cell differentiation circadian regulation of gene expression protein homodimerization activity histone deacetylase binding bHLH transcription factor binding MRF binding negative regulation of transcription, DNA-templated protein heterodimerization activity protein dimerization activity rhythmic process regulation of neurogenesis E-box binding N-box binding uc009ert.1 uc009ert.2 uc009ert.3 uc009ert.4 
ENSMUST00000032396.13 Irag2 ENSMUST00000032396.13 inositol 1,4,5-triphosphate receptor associated 2, transcript variant 1 (from RefSeq NM_008511.4) ENSMUST00000032396.1 ENSMUST00000032396.10 ENSMUST00000032396.11 ENSMUST00000032396.12 ENSMUST00000032396.2 ENSMUST00000032396.3 ENSMUST00000032396.4 ENSMUST00000032396.5 ENSMUST00000032396.6 ENSMUST00000032396.7 ENSMUST00000032396.8 ENSMUST00000032396.9 G5E880 G5E880_MOUSE Irag2 Lrmp NM_008511 uc009eqz.1 uc009eqz.2 uc009eqz.3 uc009eqz.4 membrane integral component of membrane uc009eqz.1 uc009eqz.2 uc009eqz.3 uc009eqz.4 
ENSMUST00000032398.15 Thumpd3 ENSMUST00000032398.15 THUMP domain containing 3, transcript variant 1 (from RefSeq NM_008188.4) ENSMUST00000032398.1 ENSMUST00000032398.10 ENSMUST00000032398.11 ENSMUST00000032398.12 ENSMUST00000032398.13 ENSMUST00000032398.14 ENSMUST00000032398.2 ENSMUST00000032398.3 ENSMUST00000032398.4 ENSMUST00000032398.5 ENSMUST00000032398.6 ENSMUST00000032398.7 ENSMUST00000032398.8 ENSMUST00000032398.9 NM_008188 P97770 Q99M45 Q9D3P0 THUM3_MOUSE uc009del.1 uc009del.2 uc009del.3 Methyltransferase which catalyzes the formation of N(2)- methylguanosine at position 6 in a broad range of tRNA substrates containing the characteristic 3'-CCA terminus of mature tRNAs (By similarity). Also catalyzes the formation of N(2)-methylguanosine at position 7 of tRNA(Trp) (By similarity). Requires the methyltransferase adapter protein TRM112 for tRNA methyltransferase activity (By similarity). Reaction=guanosine(6) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)- methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:51116, Rhea:RHEA-COMP:12888, Rhea:RHEA-COMP:12889, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=2.1.1.256; Evidence=; Interacts with TRMT112; the interaction is direct and is required for THUMPD3 methyltransferase activity. Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P97770-1; Sequence=Displayed; Name=2; IsoId=P97770-2; Sequence=VSP_021537; Name=3; IsoId=P97770-3; Sequence=VSP_021538; Ubiquitously expressed (PubMed:9108056). Abundantly expressed in the testis, also expressed in the brain, heart, kidney, liver, lung, muscle and spleen (PubMed:34669960). Belongs to the methyltransferase superfamily. RNA binding nucleolus cytosol methyltransferase activity tRNA (guanine) methyltransferase activity transferase activity tRNA methylation methylation uc009del.1 uc009del.2 uc009del.3 
ENSMUST00000032399.12 Kras ENSMUST00000032399.12 Kirsten rat sarcoma viral oncogene homolog, transcript variant 10 (from RefSeq NR_175368.1) ENSMUST00000032399.1 ENSMUST00000032399.10 ENSMUST00000032399.11 ENSMUST00000032399.2 ENSMUST00000032399.3 ENSMUST00000032399.4 ENSMUST00000032399.5 ENSMUST00000032399.6 ENSMUST00000032399.7 ENSMUST00000032399.8 ENSMUST00000032399.9 Kras Kras2 NR_175368 Q5J7N1 Q5J7N1_MOUSE uc009erh.1 uc009erh.2 uc009erh.3 uc009erh.4 Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Cell membrane ; Lipid-anchor ; Cytoplasmic side Membrane ; Lipid-anchor ; Cytoplasmic side Belongs to the small GTPase superfamily. Ras family. nucleotide binding liver development positive regulation of protein phosphorylation GTPase activity GTP binding cytoplasm mitochondrion signal transduction female pregnancy positive regulation of cell proliferation positive regulation of gene expression membrane GMP binding GDP binding cytokine-mediated signaling pathway LRR domain binding extrinsic component of cytoplasmic side of plasma membrane regulation of protein stability response to isolation stress positive regulation of MAP kinase activity macromolecular complex binding membrane raft positive regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity response to glucocorticoid response to mineralocorticoid positive regulation of cellular senescence uc009erh.1 uc009erh.2 uc009erh.3 uc009erh.4 
ENSMUST00000032406.15 Ogg1 ENSMUST00000032406.15 8-oxoguanine DNA-glycosylase 1, transcript variant 1 (from RefSeq NM_010957.5) ENSMUST00000032406.1 ENSMUST00000032406.10 ENSMUST00000032406.11 ENSMUST00000032406.12 ENSMUST00000032406.13 ENSMUST00000032406.14 ENSMUST00000032406.2 ENSMUST00000032406.3 ENSMUST00000032406.4 ENSMUST00000032406.5 ENSMUST00000032406.6 ENSMUST00000032406.7 ENSMUST00000032406.8 ENSMUST00000032406.9 NM_010957 Ogg1 Q3UIL3 Q3UIL3_MOUSE uc009dfh.1 uc009dfh.2 uc009dfh.3 uc009dfh.4 uc009dfh.5 DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA- COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695, ChEBI:CHEBI:167181; EC=4.2.99.18; Evidence=; Belongs to the type-1 OGG1 family. acute inflammatory response damaged DNA binding catalytic activity nucleus nucleoplasm mitochondrion DNA repair base-excision repair nucleotide-excision repair regulation of transcription, DNA-templated cellular response to DNA damage stimulus response to oxidative stress aging oxidized purine nucleobase lesion DNA N-glycosylase activity response to radiation response to light stimulus nuclear matrix nuclear speck DNA N-glycosylase activity response to estradiol oxidized purine DNA binding macromolecular complex nucleotide-excision repair, DNA incision 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity response to drug negative regulation of apoptotic process response to ethanol response to folic acid cellular response to cadmium ion negative regulation of double-strand break repair via single-strand annealing uc009dfh.1 uc009dfh.2 uc009dfh.3 uc009dfh.4 uc009dfh.5 
ENSMUST00000032409.15 Camk1 ENSMUST00000032409.15 calcium/calmodulin-dependent protein kinase I (from RefSeq NM_133926.2) ENSMUST00000032409.1 ENSMUST00000032409.10 ENSMUST00000032409.11 ENSMUST00000032409.12 ENSMUST00000032409.13 ENSMUST00000032409.14 ENSMUST00000032409.2 ENSMUST00000032409.3 ENSMUST00000032409.4 ENSMUST00000032409.5 ENSMUST00000032409.6 ENSMUST00000032409.7 ENSMUST00000032409.8 ENSMUST00000032409.9 KCC1A_MOUSE NM_133926 Q91YS8 uc009dfk.1 uc009dfk.2 uc009dfk.3 Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-673', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser- 92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation. Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2- mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17; Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-177 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-177 results in several fold increase in total activity. Unlike CaMK4, is unable to exhibit autonomous activity after Ca(2+)/calmodulin activation (By similarity). Monomer. Interacts with XPO1 (By similarity). Q91YS8; P29351: Ptpn6; NbExp=3; IntAct=EBI-911352, EBI-2620699; Cytoplasm Nucleus Note=Predominantly cytoplasmic. Ubiquitous. The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate. Phosphorylated by CaMKK1 and CaMKK2 on Thr-177. Polybiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL12), leading to proteasomal degradation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. nucleotide binding catalytic activity protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity protein binding calmodulin binding ATP binding nucleus cytoplasm protein phosphorylation nucleocytoplasmic transport cell cycle signal transduction multicellular organism development nervous system development metabolic process positive regulation of neuron projection development postsynaptic density kinase activity phosphorylation transferase activity cell differentiation negative regulation of protein binding regulation of protein localization positive regulation of peptidyl-serine phosphorylation regulation of protein binding positive regulation of transcription from RNA polymerase II promoter positive regulation of protein export from nucleus regulation of synapse organization regulation of muscle cell differentiation positive regulation of muscle cell differentiation positive regulation of synapse structural plasticity positive regulation of syncytium formation by plasma membrane fusion positive regulation of dendritic spine development positive regulation of protein serine/threonine kinase activity glutamatergic synapse positive regulation of protein acetylation uc009dfk.1 uc009dfk.2 uc009dfk.3 
ENSMUST00000032410.14 Tada3 ENSMUST00000032410.14 transcriptional adaptor 3, transcript variant 1 (from RefSeq NM_133932.3) Ada3 ENSMUST00000032410.1 ENSMUST00000032410.10 ENSMUST00000032410.11 ENSMUST00000032410.12 ENSMUST00000032410.13 ENSMUST00000032410.2 ENSMUST00000032410.3 ENSMUST00000032410.4 ENSMUST00000032410.5 ENSMUST00000032410.6 ENSMUST00000032410.7 ENSMUST00000032410.8 ENSMUST00000032410.9 NM_133932 Q8CIH4 Q8K289 Q8R0L9 Q8R5E3 Q9CTJ0 TADA3_MOUSE Tada3l uc009dfo.1 uc009dfo.2 uc009dfo.3 uc009dfo.4 uc009dfo.5 Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53- dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Interacts directly with TADA2L and PCAF and also with the high-risk HPV oncoprotein E6. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Component of the TFTC-HAT complex (By similarity). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R0L9-1; Sequence=Displayed; Name=2; IsoId=Q8R0L9-2; Sequence=VSP_009740; Name=3; IsoId=Q8R0L9-3; Sequence=VSP_009741; Belongs to the NGG1 family. SAGA complex mitotic cell cycle regulation of protein phosphorylation transcription coactivator activity histone acetyltransferase activity protein binding nucleus nucleoplasm Ada2/Gcn5/Ada3 transcription activator complex regulation of transcription from RNA polymerase II promoter positive regulation of gene expression ligand-dependent nuclear receptor binding protein domain specific binding ligand-dependent nuclear receptor transcription coactivator activity STAGA complex regulation of histone deacetylation regulation of protein stability transcription factor TFTC complex histone H3 acetylation histone H4 acetylation positive regulation of transcription, DNA-templated mitotic spindle regulation of tubulin deacetylation uc009dfo.1 uc009dfo.2 uc009dfo.3 uc009dfo.4 uc009dfo.5 
ENSMUST00000032413.7 Etnk1 ENSMUST00000032413.7 ethanolamine kinase 1 (from RefSeq NM_029250.2) EKI1_MOUSE ENSMUST00000032413.1 ENSMUST00000032413.2 ENSMUST00000032413.3 ENSMUST00000032413.4 ENSMUST00000032413.5 ENSMUST00000032413.6 Eki1 F6Y9V2 NM_029250 Q8BXQ0 Q9D4V0 uc009eqf.1 uc009eqf.2 uc009eqf.3 uc009eqf.4 uc009eqf.5 Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. Reaction=ATP + ethanolamine = ADP + H(+) + phosphoethanolamine; Xref=Rhea:RHEA:13069, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57603, ChEBI:CHEBI:58190, ChEBI:CHEBI:456216; EC=2.7.1.82; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13070; Evidence=; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. Cytoplasm Belongs to the choline/ethanolamine kinase family. nucleotide binding ethanolamine kinase activity ATP binding nucleoplasm cytoplasm cytosol plasma membrane lipid metabolic process phosphatidylethanolamine biosynthetic process phospholipid biosynthetic process kinase activity phosphorylation transferase activity uc009eqf.1 uc009eqf.2 uc009eqf.3 uc009eqf.4 uc009eqf.5 
ENSMUST00000032414.11 Ttll3 ENSMUST00000032414.11 tubulin tyrosine ligase-like family, member 3, transcript variant 1 (from RefSeq NM_133923.7) A4Q9E5 ENSMUST00000032414.1 ENSMUST00000032414.10 ENSMUST00000032414.2 ENSMUST00000032414.3 ENSMUST00000032414.4 ENSMUST00000032414.5 ENSMUST00000032414.6 ENSMUST00000032414.7 ENSMUST00000032414.8 ENSMUST00000032414.9 NM_133923 Q8BV51 Q8C0Y7 Q8VDS2 TTLL3_MOUSE Ttll3 uc009dfv.1 uc009dfv.2 uc009dfv.3 uc009dfv.4 uc009dfv.5 Monoglycylase which modifies alpha- and beta-tubulin, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of tubulin (PubMed:19524510). Not involved in elongation step of the polyglycylation reaction (PubMed:19524510). Preferentially glycylates a beta-tail peptide over the alpha-tail, although shifts its preference toward alpha-tail as beta-tail glutamylation increases (By similarity). Competes with polyglutamylases for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (PubMed:33414192). Together with TTLL8, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance (PubMed:23897886, PubMed:25180231). Involved in microtubule glycylation of primary cilia in colon which controls cell proliferation of epithelial cells and plays an essential role in colon cancer development (PubMed:25180231). Together with TTLL8, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility (PubMed:33414192). Reaction=ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L- glutamyl-[protein] + H(+) + phosphate; Xref=Rhea:RHEA:67180, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:17207, ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:167890, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67181; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm, cytoskeleton Cell projection, cilium Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=A4Q9E5-1; Sequence=Displayed; Name=2 ; IsoId=A4Q9E5-2; Sequence=VSP_052724, VSP_052725, VSP_052726; Name=3 ; IsoId=A4Q9E5-3; Sequence=VSP_052722, VSP_052723; Highly expressed in brain and testis (PubMed:17499049, PubMed:25180231). Expressed in heart, kidney, liver, lung, muscle, spleen, trachea and colon (PubMed:17499049, PubMed:25180231, PubMed:33414192). Expressed in sperm flagellum (PubMed:33414192). In the brain, specifically expressed in ependymal cilia (PubMed:23897886). Two conserved structural elements specific among monoglycylases, IS1 and IS2, are involved in glycyl chains initiation. Two conserved structural interfaces likely constitute the binding platforms for tubulin tail and microtubule. Arg-482 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate- chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation. In knockout mice, colon epithelium shows absence of glycylation, a reduced number of primary cilia accompanied by an increased rate of cell division (PubMed:25180231). Knockout mice show no visible motile ependymal cilia phenotype (PubMed:23897886). Simultaneous TTLL3 and TTLL8 knockout mice are subfertile owing to aberrant beat patterns of their sperm flagella, which impeded the straight swimming of sperm cells (PubMed:33414192). Simultaneous TTLL3 and TTLL8 knockout mice show no visible motile ependymal cilia phenotype in brain ventricles (PubMed:33414192). TTLL3 and TTLL8 monoglycylase-mediated glycylation of tubulin was initially reported to play a role in ependymal motile ciliary maintenance (PubMed:23897886). However, contradictory results were later observed (PubMed:33414192). nucleotide binding ATP binding cytoplasm cytoskeleton microtubule cilium axoneme cellular protein modification process microtubule cytoskeleton ligase activity protein polyglycylation axoneme assembly cell projection cilium assembly protein-glycine ligase activity protein-glycine ligase activity, initiating uc009dfv.1 uc009dfv.2 uc009dfv.3 uc009dfv.4 uc009dfv.5 
ENSMUST00000032419.9 Cmas ENSMUST00000032419.9 cytidine monophospho-N-acetylneuraminic acid synthetase, transcript variant 5 (from RefSeq NR_176870.1) A0A0R4J0B4 A0A0R4J0B4_MOUSE Cmas ENSMUST00000032419.1 ENSMUST00000032419.2 ENSMUST00000032419.3 ENSMUST00000032419.4 ENSMUST00000032419.5 ENSMUST00000032419.6 ENSMUST00000032419.7 ENSMUST00000032419.8 NR_176870 uc009eps.1 uc009eps.2 uc009eps.3 Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D- glycero-D-galacto-nononic acid (KDN). Reaction=an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate; Xref=Rhea:RHEA:11344, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:60073, ChEBI:CHEBI:68671; EC=2.7.7.43; Evidence=; Amino-sugar metabolism; N-acetylneuraminate metabolism. Homotetramer; the active enzyme is formed by a dimer of dimers. Belongs to the CMP-NeuNAc synthase family. uc009eps.1 uc009eps.2 uc009eps.3 
ENSMUST00000032421.4 St8sia1 ENSMUST00000032421.4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (from RefSeq NM_011374.2) ENSMUST00000032421.1 ENSMUST00000032421.2 ENSMUST00000032421.3 NM_011374 Q64687 Q8K1C1 SIA8A_MOUSE Siat8 Siat8a uc009epv.1 uc009epv.2 uc009epv.3 Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphingolipds that contain one or more residues of sialic acid (PubMed:8910600). Can catalyze the addition of a second alpha-2,8- sialic acid to GD3 to form GT3 (PubMed:8910600). Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (PubMed:8910600). Reaction=an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha- neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+); Xref=Rhea:RHEA:19313, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:140308, ChEBI:CHEBI:140309; EC=2.4.3.8; Evidence=; Reaction=a ganglioside GM3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41760, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60065, ChEBI:CHEBI:60377, ChEBI:CHEBI:78436; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41761; Evidence=; Reaction=a ganglioside GD3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT3 (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41764, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78436, ChEBI:CHEBI:78438; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41765; Evidence=; Reaction=a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1a (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41768, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78445, ChEBI:CHEBI:78447; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41769; Evidence=; Reaction=a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1b (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41772, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78452, ChEBI:CHEBI:78455; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41773; Evidence=; Reaction=a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:47576, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568, ChEBI:CHEBI:87787; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47577; Evidence=; Kinetic parameters: KM=0.03 mM for ganglioside GM3 ; KM=5 mM for ganglioside GD3 ; KM=5 mM for ganglioside GD1a ; KM=2 mM for ganglioside GT1b ; Protein modification; protein glycosylation. Lipid metabolism; sphingolipid metabolism. Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 29 family. Name=Functional Glycomics Gateway - GTase; Note=ST8Sia I; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_656"; Golgi membrane alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Golgi apparatus protein glycosylation lipid metabolic process sphingolipid metabolic process positive regulation of cell proliferation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups cellular response to heat sialylation uc009epv.1 uc009epv.2 uc009epv.3 
ENSMUST00000032422.6 Creld1 ENSMUST00000032422.6 cysteine-rich with EGF-like domains 1, transcript variant 1 (from RefSeq NM_133930.2) CREL1_MOUSE ENSMUST00000032422.1 ENSMUST00000032422.2 ENSMUST00000032422.3 ENSMUST00000032422.4 ENSMUST00000032422.5 NM_133930 Q8BGJ8 Q91XD7 uc009dgo.1 uc009dgo.2 uc009dgo.3 Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (PubMed:30407909). Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; Evidence=; Membrane ; Multi-pass membrane protein Expressed in myoblast C2C12 cells (at protein level). Belongs to the CRELD family. protein disulfide isomerase activity extracellular matrix structural constituent calcium ion binding cellular_component biological_process membrane integral component of membrane uc009dgo.1 uc009dgo.2 uc009dgo.3 
ENSMUST00000032425.7 Emc3 ENSMUST00000032425.7 ER membrane protein complex subunit 3 (from RefSeq NM_175101.3) EMC3_MOUSE ENSMUST00000032425.1 ENSMUST00000032425.2 ENSMUST00000032425.3 ENSMUST00000032425.4 ENSMUST00000032425.5 ENSMUST00000032425.6 NM_175101 Q3TIK3 Q99KI3 Tmem111 uc009dgu.1 uc009dgu.2 uc009dgu.3 Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N- exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Component of the ER membrane protein complex (EMC). Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the EMC3 family. molecular_function membrane integral component of membrane ER membrane protein complex uc009dgu.1 uc009dgu.2 uc009dgu.3 
ENSMUST00000032427.15 Ints13 ENSMUST00000032427.15 integrator complex subunit 13, transcript variant 5 (from RefSeq NR_155292.1) Asun E9QLV7 ENSMUST00000032427.1 ENSMUST00000032427.10 ENSMUST00000032427.11 ENSMUST00000032427.12 ENSMUST00000032427.13 ENSMUST00000032427.14 ENSMUST00000032427.2 ENSMUST00000032427.3 ENSMUST00000032427.4 ENSMUST00000032427.5 ENSMUST00000032427.6 ENSMUST00000032427.7 ENSMUST00000032427.8 ENSMUST00000032427.9 INT13_MOUSE IntS13 NR_155292 Q8QZV7 Q99JT8 Spata30 uc009esb.1 uc009esb.2 Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. Interacts with PAFAH1B1; this interaction may be required for proper recruitment of dynein complexes to the nuclear envelope at prophase. Nucleus Cytoplasm Note=Nuclear location is required for recruitment of dynein motors to nuclear envelope at G2/M. Belongs to the asunder family. molecular_function nucleus cytoplasm cell cycle mitotic spindle organization regulation of mitotic cell cycle flagellated sperm motility cell division centrosome localization regulation of fertilization protein localization to nuclear envelope uc009esb.1 uc009esb.2 
ENSMUST00000032429.9 Med21 ENSMUST00000032429.9 mediator complex subunit 21 (from RefSeq NM_025315.3) ENSMUST00000032429.1 ENSMUST00000032429.2 ENSMUST00000032429.3 ENSMUST00000032429.4 ENSMUST00000032429.5 ENSMUST00000032429.6 ENSMUST00000032429.7 ENSMUST00000032429.8 MED21_MOUSE NM_025315 Q921I5 Q9CQ39 Srb7 Surb7 uc009esg.1 uc009esg.2 uc009esg.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with THRA in a ligand-dependent fashion (By similarity). Interacts with PPARG. Nucleus Expressed in brain, heart, kidney, liver, lung, skeletal muscles, spleen and testis. Belongs to the Mediator complex subunit 21 family. ubiquitin ligase complex blastocyst development transcription cofactor activity transcription coactivator activity protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein ubiquitination mediator complex stem cell population maintenance positive regulation of transcription from RNA polymerase II promoter ubiquitin protein ligase activity uc009esg.1 uc009esg.2 uc009esg.3 
ENSMUST00000032433.9 Smco2 ENSMUST00000032433.9 single-pass membrane protein with coiled-coil domains 2 (from RefSeq NM_027059.1) ENSMUST00000032433.1 ENSMUST00000032433.2 ENSMUST00000032433.3 ENSMUST00000032433.4 ENSMUST00000032433.5 ENSMUST00000032433.6 ENSMUST00000032433.7 ENSMUST00000032433.8 NM_027059 Q9DA21 SMCO2_MOUSE uc009esl.1 uc009esl.2 uc009esl.3 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009esl.1 uc009esl.2 uc009esl.3 
ENSMUST00000032440.6 Sec13 ENSMUST00000032440.6 SEC13 homolog, nuclear pore and COPII coat complex component (from RefSeq NM_024206.4) ENSMUST00000032440.1 ENSMUST00000032440.2 ENSMUST00000032440.3 ENSMUST00000032440.4 ENSMUST00000032440.5 NM_024206 Q99M12 Q9D1M0 Q9D712 SEC13_MOUSE Sec13l1 uc009dhm.1 uc009dhm.2 uc009dhm.3 Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (PubMed:27354378). As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex. The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids. In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated. At the nuclear pore: component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13. At the COPII coat complex: interacts with SEC31A and SEC31B. Interacts with SEC16A. Interacts with SEC16B. Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids. Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus, nuclear pore complex Lysosome membrane Note=In interphase, localizes at both sides of the NPC. Belongs to the WD repeat SEC13 family. Golgi membrane kinetochore structural molecule activity nucleus nuclear envelope nuclear pore nucleoplasm lysosome lysosomal membrane endoplasmic reticulum endoplasmic reticulum membrane cytosol ER to Golgi vesicle-mediated transport ER to Golgi transport vesicle membrane protein transport membrane vesicle-mediated transport COPII vesicle coat nuclear pore outer ring cytoplasmic vesicle positive regulation of TOR signaling protein exit from endoplasmic reticulum macromolecular complex identical protein binding intracellular membrane-bounded organelle mRNA transport GATOR2 complex protein localization to plasma membrane cargo loading into COPII-coated vesicle COPII-coated vesicle budding positive regulation of TORC1 signaling uc009dhm.1 uc009dhm.2 uc009dhm.3 
ENSMUST00000032441.14 Ccdc91 ENSMUST00000032441.14 coiled-coil domain containing 91, transcript variant 1 (from RefSeq NM_025911.2) CCD91_MOUSE ENSMUST00000032441.1 ENSMUST00000032441.10 ENSMUST00000032441.11 ENSMUST00000032441.12 ENSMUST00000032441.13 ENSMUST00000032441.2 ENSMUST00000032441.3 ENSMUST00000032441.4 ENSMUST00000032441.5 ENSMUST00000032441.6 ENSMUST00000032441.7 ENSMUST00000032441.8 ENSMUST00000032441.9 Ggabp NM_025911 Q8R3N8 Q9D8L5 Q9D9E8 uc009esy.1 uc009esy.2 Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. Homodimer. Interacts with GGA1, GGA2 and AP1G1. Membrane ; Peripheral membrane protein Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Golgi apparatus, trans-Golgi network Note=Colocalizes with GGA1, GGA2 and GGA3. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D8L5-1; Sequence=Displayed; Name=2; IsoId=Q9D8L5-2; Sequence=VSP_013245, VSP_013246, VSP_013247; Sequence=AAH24946.1; Type=Erroneous initiation; Evidence=; nucleoplasm Golgi apparatus trans-Golgi network cytosol protein transport membrane identical protein binding Golgi vesicle transport Golgi to lysosome transport uc009esy.1 uc009esy.2 
ENSMUST00000032443.14 Far2 ENSMUST00000032443.14 fatty acyl CoA reductase 2, transcript variant 1 (from RefSeq NM_001347516.1) B2KFC6 ENSMUST00000032443.1 ENSMUST00000032443.10 ENSMUST00000032443.11 ENSMUST00000032443.12 ENSMUST00000032443.13 ENSMUST00000032443.2 ENSMUST00000032443.3 ENSMUST00000032443.4 ENSMUST00000032443.5 ENSMUST00000032443.6 ENSMUST00000032443.7 ENSMUST00000032443.8 ENSMUST00000032443.9 FACR2_MOUSE Far2 NM_001347516 Q3TTT7 Q7TNT2 Q8BH72 Q8CAK7 uc009etb.1 uc009etb.2 uc009etb.3 uc009etb.4 Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates (PubMed:15220348). It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity). Reaction=a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+); Xref=Rhea:RHEA:52716, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:77396, ChEBI:CHEBI:83139; EC=1.2.1.84; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52717; Evidence=; Reaction=2 H(+) + hexadecanoyl-CoA + 2 NADPH = CoA + hexadecan-1-ol + 2 NADP(+); Xref=Rhea:RHEA:36315, ChEBI:CHEBI:15378, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.2.1.84; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36316; Evidence=; Reaction=2 H(+) + 2 NADPH + octadecanoyl-CoA = CoA + 2 NADP(+) + octadecan-1-ol; Xref=Rhea:RHEA:36319, ChEBI:CHEBI:15378, ChEBI:CHEBI:32154, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.2.1.84; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36320; Evidence=; Peroxisome membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TNT2-1; Sequence=Displayed; Name=2; IsoId=Q7TNT2-2; Sequence=VSP_021682; Specifically expressed in the meibomian glands of the eyelid and the sebaceous glands of the skin. Also expressed in the brain where large quantities of ether lipids are synthesized. Belongs to the fatty acyl-CoA reductase family. peroxisome peroxisomal membrane integral component of peroxisomal membrane lipid metabolic process wax biosynthetic process membrane integral component of membrane oxidoreductase activity long-chain fatty-acyl-CoA metabolic process oxidation-reduction process fatty-acyl-CoA reductase (alcohol-forming) activity uc009etb.1 uc009etb.2 uc009etb.3 uc009etb.4 
ENSMUST00000032451.9 Slc6a11 ENSMUST00000032451.9 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 (from RefSeq NM_172890.3) ENSMUST00000032451.1 ENSMUST00000032451.2 ENSMUST00000032451.3 ENSMUST00000032451.4 ENSMUST00000032451.5 ENSMUST00000032451.6 ENSMUST00000032451.7 ENSMUST00000032451.8 Gabt3 Gabt4 Gat-4 Gat3 Gat4 NM_172890 P31650 Q8BWA7 S6A11_MOUSE uc009dhs.1 uc009dhs.2 uc009dhs.3 Mediates sodium- and chloride-dependent transport of gamma- aminobutyric acid (GABA) (PubMed:8420981, PubMed:30270321). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (PubMed:8420981, PubMed:30270321). Reaction=4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) = 4- aminobutanoate(in) + chloride(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70687, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:59888; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70688; Evidence=; Reaction=chloride(out) + 2 Na(+)(out) + taurine(out) = chloride(in) + 2 Na(+)(in) + taurine(in); Xref=Rhea:RHEA:71223, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:507393; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71224; Evidence=; Reaction=beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta- alanine(in) + chloride(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71247, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57966; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71248; Evidence=; Reaction=chloride(out) + hypotaurine(out) + 2 Na(+)(out) = chloride(in) + hypotaurine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71243, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57853; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71244; Evidence=; GABA transport is inhibited by beta-alanine, taurine, hypotaurine, beta-guanidinopropionic acid and 2,3- diaminopropionic acid (PubMed:8420981). Beta-alanine transport is inhibited by GABA (PubMed:8420981). Kinetic parameters: KM=0.8 uM for GABA ; KM=2.24 uM for GABA ; KM=99 uM for beta-alanine ; KM=1.4 mM for taurine ; Cell membrane ; Multi-pass membrane protein Brain. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily. neurotransmitter uptake neurotransmitter:sodium symporter activity gamma-aminobutyric acid:sodium symporter activity cytoplasm plasma membrane integral component of plasma membrane neurotransmitter transport brain development symporter activity gamma-aminobutyric acid transport membrane integral component of membrane neurotransmitter binding response to drug cell projection neuron projection synapse transmembrane transport neurotransmitter reuptake GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane uc009dhs.1 uc009dhs.2 uc009dhs.3 
ENSMUST00000032454.8 Slc6a1 ENSMUST00000032454.8 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 (from RefSeq NM_178703.5) ENSMUST00000032454.1 ENSMUST00000032454.2 ENSMUST00000032454.3 ENSMUST00000032454.4 ENSMUST00000032454.5 ENSMUST00000032454.6 ENSMUST00000032454.7 Gabt1 Gat-1 Gat1 NM_178703 P31648 SC6A1_MOUSE uc009dhv.1 uc009dhv.2 uc009dhv.3 uc009dhv.4 Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:15234345, PubMed:16150932, PubMed:8420981, PubMed:30270321). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride- dependent transport of hypotaurine but to a much lower extent as compared to GABA (PubMed:30270321). Reaction=4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) = 4- aminobutanoate(in) + chloride(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70687, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:59888; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70688; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70689; Evidence=; Reaction=chloride(out) + hypotaurine(out) + 2 Na(+)(out) = chloride(in) + hypotaurine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71243, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57853; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71244; Evidence=; Inhibited by N-[4,4-Diphenyl-3-butenyl]-nipecotic acid (SKF-89976-A), L-2,4-diamino-n-butyric acid, guvacine and nipecotic acid. Kinetic parameters: KM=62 uM for GABA ; Interacts (via PDZ domain-binding motif) with PALS1; interaction increases SLC6A1-mediated GABA uptake. Cell membrane ; Multi-pass membrane protein Presynapse Note=Localized at the presynaptic terminals of interneurons. Brain. Expressed in the dentate gyrus of hippocampus, striatum and cerebellum (at protein level). This protein is the target of psychomotor stimulants such as amphetamines or cocaine. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily. neurotransmitter:sodium symporter activity gamma-aminobutyric acid:sodium symporter activity plasma membrane integral component of plasma membrane neurotransmitter transport learning response to toxic substance response to sucrose cell surface response to organic substance response to organonitrogen compound response to lead ion positive regulation of gamma-aminobutyric acid secretion response to organic cyclic compound response to purine-containing compound symporter activity taurine transport membrane integral component of membrane axon negative regulation of synaptic transmission, GABAergic response to estradiol neurotransmitter binding response to cocaine neuron projection metal ion binding protein homooligomerization response to calcium ion gamma-aminobutyric acid import transmembrane transport neurotransmitter reuptake GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane uc009dhv.1 uc009dhv.2 uc009dhv.3 uc009dhv.4 
ENSMUST00000032457.17 Atg7 ENSMUST00000032457.17 autophagy related 7, transcript variant 5 (from RefSeq NR_166516.1) ATG7_MOUSE Apg7l ENSMUST00000032457.1 ENSMUST00000032457.10 ENSMUST00000032457.11 ENSMUST00000032457.12 ENSMUST00000032457.13 ENSMUST00000032457.14 ENSMUST00000032457.15 ENSMUST00000032457.16 ENSMUST00000032457.2 ENSMUST00000032457.3 ENSMUST00000032457.4 ENSMUST00000032457.5 ENSMUST00000032457.6 ENSMUST00000032457.7 ENSMUST00000032457.8 ENSMUST00000032457.9 NR_166516 Q3TCD9 Q8K4Q5 Q9D906 uc009dhz.1 uc009dhz.2 uc009dhz.3 This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes (By similarity). Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (PubMed:29937374). Homodimer. Interacts with ATG3, FOXO1 and EP300 acetyltransferase. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Interacts with FOXO1 (By similarity). Forms intermediate conjugates with ATG8 family proteins such as GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, or GABARAPL1. Interacts with ATG12. Cytoplasm Preautophagosomal structure Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12. The N-terminal FAP motif (residues 11 to 13) is essential for the formation of the ATG89-PE and ATG5-ATG12 conjugates. Acetylated by EP300. Leads to hepatomegaly in liver and accumulation of abnormal organelles in hepatic cells (PubMed:15866887). Liver- specific knockout leads to loss of autophagy, increased accumulation of CRY1, decreased blood glucose levels due to impaired gluconeogenesis and the disruption of the circadian clock in the liver (PubMed:29937374). Belongs to the ATG7 family. autophagosome assembly pre-autophagosomal structure mitophagy liver development protein binding cytoplasm cytosol axoneme protein lipidation C-terminal protein lipidation autophagy cellular response to nitrogen starvation organelle organization mitochondrion organization adult walking behavior transcription factor binding small protein activating enzyme activity cellular response to starvation post-embryonic development positive regulation of autophagy protein transport macroautophagy cellular homeostasis Atg12 activating enzyme activity Atg8 activating enzyme activity cerebellar Purkinje cell layer development pyramidal neuron development central nervous system neuron axonogenesis cerebral cortex development protein catabolic process axon neuron projection development regulation of protein ubiquitination positive regulation of protein modification process positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein modification by small protein conjugation cellular response to reactive oxygen species piecemeal microautophagy of nucleus positive regulation of insulin secretion involved in cellular response to glucose stimulus suppression by virus of host autophagy negative stranded viral RNA replication response to starvation regulation of circadian rhythm protein homodimerization activity positive regulation of apoptotic process negative regulation of apoptotic process late nucleophagy positive regulation of protein catabolic process perinuclear region of cytoplasm rhythmic process negative regulation of phagocytosis neurological system process defense response to virus cardiac muscle cell development regulation of cell development negative regulation of cell death membrane organization chaperone-mediated autophagy positive regulation of mucus secretion cellular response to hyperoxia autophagy of host cells involved in interaction with symbiont amino acid homeostasis negative regulation of sphingolipid biosynthetic process cellular sphingolipid homeostasis negative regulation of mitochondrial DNA replication regulation of neuron death negative regulation of oxidative stress-induced neuron death regulation of hemopoiesis negative regulation of histone H4-K16 acetylation uc009dhz.1 uc009dhz.2 uc009dhz.3 
ENSMUST00000032459.14 Vgll4 ENSMUST00000032459.14 vestigial like family member 4, transcript variant 1 (from RefSeq NM_177683.4) ENSMUST00000032459.1 ENSMUST00000032459.10 ENSMUST00000032459.11 ENSMUST00000032459.12 ENSMUST00000032459.13 ENSMUST00000032459.2 ENSMUST00000032459.3 ENSMUST00000032459.4 ENSMUST00000032459.5 ENSMUST00000032459.6 ENSMUST00000032459.7 ENSMUST00000032459.8 ENSMUST00000032459.9 NM_177683 Q80V24 VGLL4_MOUSE uc009dif.1 uc009dif.2 uc009dif.3 uc009dif.4 uc009dif.5 May act as a specific coactivator for the mammalian TEFs. Interacts with TEFs. Interacts with IRF2BP2 (By similarity). Q80V24; Q62296: Tead4; NbExp=3; IntAct=EBI-9253433, EBI-9253444; Q80V24; Q15561: TEAD4; Xeno; NbExp=3; IntAct=EBI-9253433, EBI-747736; Nucleus Belongs to the vestigial family. transcription coactivator binding protein binding nucleus regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated uc009dif.1 uc009dif.2 uc009dif.3 uc009dif.4 uc009dif.5 
ENSMUST00000032461.12 Tamm41 ENSMUST00000032461.12 TAM41 mitochondrial translocator assembly and maintenance homolog (from RefSeq NM_026894.1) 1500001M20Rik ENSMUST00000032461.1 ENSMUST00000032461.10 ENSMUST00000032461.11 ENSMUST00000032461.2 ENSMUST00000032461.3 ENSMUST00000032461.4 ENSMUST00000032461.5 ENSMUST00000032461.6 ENSMUST00000032461.7 ENSMUST00000032461.8 ENSMUST00000032461.9 G5E881 G5E881_MOUSE NM_026894 Tamm41 uc009dij.1 uc009dij.2 uc009dij.3 Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol. Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2- diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Lipid metabolism. Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 3/3. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the TAM41 family. phosphatidate cytidylyltransferase activity mitochondrion mitochondrial inner membrane lipid metabolic process phospholipid biosynthetic process membrane CDP-diacylglycerol biosynthetic process transferase activity nucleotidyltransferase activity cardiolipin biosynthetic process uc009dij.1 uc009dij.2 uc009dij.3 
ENSMUST00000032462.9 Timp4 ENSMUST00000032462.9 tissue inhibitor of metalloproteinase 4, transcript variant 3 (from RefSeq NR_151459.1) ENSMUST00000032462.1 ENSMUST00000032462.2 ENSMUST00000032462.3 ENSMUST00000032462.4 ENSMUST00000032462.5 ENSMUST00000032462.6 ENSMUST00000032462.7 ENSMUST00000032462.8 NR_151459 Q924B7 Q9JHB3 TIMP4_MOUSE uc009dip.1 uc009dip.2 uc009dip.3 Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Secreted. Expressed in brain, heart, ovary and skeletal muscle. Belongs to the protease inhibitor I35 (TIMP) family. protease binding enzyme inhibitor activity extracellular region extracellular space Notch signaling pathway central nervous system development metalloendopeptidase inhibitor activity zinc ion binding response to hormone response to organic substance negative regulation of peptidase activity negative regulation of endopeptidase activity sarcomere peptidase inhibitor activity extracellular matrix response to lipopolysaccharide response to cytokine response to drug ovulation cycle response to peptide hormone metal ion binding negative regulation of membrane protein ectodomain proteolysis uc009dip.1 uc009dip.2 uc009dip.3 
ENSMUST00000032469.13 Mbd4 ENSMUST00000032469.13 methyl-CpG binding domain protein 4, transcript variant 8 (from RefSeq NR_176943.1) A0A0R4J0A8 A0A0R4J0A8_MOUSE ENSMUST00000032469.1 ENSMUST00000032469.10 ENSMUST00000032469.11 ENSMUST00000032469.12 ENSMUST00000032469.2 ENSMUST00000032469.3 ENSMUST00000032469.4 ENSMUST00000032469.5 ENSMUST00000032469.6 ENSMUST00000032469.7 ENSMUST00000032469.8 ENSMUST00000032469.9 Mbd4 NR_176943 uc009dje.1 uc009dje.2 uc009dje.3 uc009dje.4 Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. Interacts with MLH1. Nucleus DNA binding catalytic activity nucleus DNA repair cellular response to DNA damage stimulus pyrimidine-specific mismatch base pair DNA N-glycosylase activity nuclear speck hydrolase activity response to estradiol uc009dje.1 uc009dje.2 uc009dje.3 uc009dje.4 
ENSMUST00000032471.9 Rho ENSMUST00000032471.9 rhodopsin (from RefSeq NM_145383.2) ENSMUST00000032471.1 ENSMUST00000032471.2 ENSMUST00000032471.3 ENSMUST00000032471.4 ENSMUST00000032471.5 ENSMUST00000032471.6 ENSMUST00000032471.7 ENSMUST00000032471.8 NM_145383 OPSD_MOUSE P15409 Q8K0D8 Q96DZ2 uc009djk.1 uc009djk.2 uc009djk.3 Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (PubMed:9020854). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:27353443). Homodimer (By similarity). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity). Interacts with GRK1 (By similarity). Interacts (phosphorylated form) with SAG (By similarity). Interacts with GNAT1 (By similarity). Interacts with GNAT3. SAG and G-proteins compete for a common binding site (By similarity). Interacts with PRCD; the interaction promotes PRCD stability (PubMed:27509380). Forms a complex with ASAP1 and ARF4. Forms a complex with ASAP1, RAB11A, Rabin8/RAB3IP, ARF4 and RAB11FIP3; the complex regulates Golgi-to-cilia rhodopsin/RHO transport in photoreceptors (By similarity). Membrane ; Multi- pass membrane protein Cell projection, cilium, photoreceptor outer segment Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia. Rod-shaped photoreceptor cells in the retina (at protein level). Expressed in the outer segment of retinal photoreceptors at postnatal days 11 and 22. Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all- trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal. Mice show no response in electroretinograms at low light intensity (PubMed:9020854). They fail to form rod outer segments leading to degeneration of photoreceptor cells within 3 months of birth (PubMed:9020854, PubMed:32312889). Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. photoreceptor outer segment photoreceptor inner segment G-protein coupled receptor activity 11-cis retinal binding protein binding Golgi apparatus plasma membrane integral component of plasma membrane cell-cell junction protein phosphorylation signal transduction G-protein coupled receptor signaling pathway visual perception phototransduction G-protein coupled photoreceptor activity response to light stimulus detection of light stimulus red, far-red light phototransduction photoreceptor activity membrane integral component of membrane absorption of visible light rhodopsin mediated signaling pathway retinal binding protein-chromophore linkage spectrin binding rough endoplasmic reticulum membrane photoreceptor outer segment membrane cell projection photoreceptor cell maintenance metal ion binding response to stimulus sensory perception of light stimulus retina development in camera-type eye photoreceptor inner segment membrane cellular response to light stimulus photoreceptor disc membrane uc009djk.1 uc009djk.2 uc009djk.3 
ENSMUST00000032472.11 Klrb1b ENSMUST00000032472.11 killer cell lectin-like receptor subfamily B member 1B, transcript variant 1 (from RefSeq NM_030599.4) ENSMUST00000032472.1 ENSMUST00000032472.10 ENSMUST00000032472.2 ENSMUST00000032472.3 ENSMUST00000032472.4 ENSMUST00000032472.5 ENSMUST00000032472.6 ENSMUST00000032472.7 ENSMUST00000032472.8 ENSMUST00000032472.9 KRBBB_MOUSE Klrb1d Ly55d NM_030599 Nkrp1b Nkrp1d Q3TE58 Q497F5 Q7TMP8 Q8BRW0 Q925G5 Q99JB4 Q99P32 uc009ees.1 uc009ees.2 uc009ees.3 uc009ees.4 Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent 'missing-self' recognition of allografts, tumor cells and virus-infected cells. Homodimer; disulfide-linked. Interacts with tyrosine kinase LCK. Binds PTPN6/SHP-1 in a phosphorylation-dependent manner. Membrane ; Single-pass type II membrane protein Expressed in NK cells and a subset of T-cells. Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases leading to down-regulation of cell activation. Variants Thr-191 and Ala-191 interfere with binding of the anti-NK1.1 monoclonal antibody PK136 which identifies NK cells from C57BL/6 and SJL but not BALB/c mice by binding Klrb1b and Klrb1c in an allele-dependent manner. Mutagenesis of Thr-191 to Ser-191 restores NK1.1 reactivity to Klrb1b from BALB/c mice. protein binding plasma membrane integral component of plasma membrane external side of plasma membrane membrane integral component of membrane carbohydrate binding signaling receptor activity protein homodimerization activity negative regulation of natural killer cell mediated cytotoxicity uc009ees.1 uc009ees.2 uc009ees.3 uc009ees.4 
ENSMUST00000032473.7 Iigp1 ENSMUST00000032473.7 interferon inducible GTPase 1, transcript variant 2 (from RefSeq NM_001146275.1) ENSMUST00000032473.1 ENSMUST00000032473.2 ENSMUST00000032473.3 ENSMUST00000032473.4 ENSMUST00000032473.5 ENSMUST00000032473.6 IIGP1_MOUSE Irga6 NM_001146275 Q9QZ85 Q9Z1M3 uc008fad.1 uc008fad.2 uc008fad.3 uc008fad.4 uc008fad.5 GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; Monomer, as apoenzyme and in the GDP-bound form. Homooligomer, upon GTP binding. Interacts with HOOK3. Q9QZ85; Q9QZ85: Iigp1; NbExp=2; IntAct=EBI-6910173, EBI-6910173; Q9QZ85; A1E140: ROP18; Xeno; NbExp=3; IntAct=EBI-6910173, EBI-15902261; Cytoplasm. Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Parasitophorous vacuole membrane. Note=Localizes to the bacterial inclusions formed following C.trachomatis infection. Accumulates in a GTP-bound form on the parasitophorous vacuole membranes formed following T.gondii infection but exists in a GDP-bound form in uninfected cells. Up-regulated by IFNG, IFNA1 and lipopolysaccharide (LPS) within 20 hours. Transiently up-regulated during the early stages of infection by Listeria monocytogenes. After 6 days expression is back to basal levels. Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. nucleotide binding immune system process GTPase activity protein binding GTP binding nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus defense response response to bacterium regulation of autophagy membrane hydrolase activity GDP binding cytokine-mediated signaling pathway symbiont-containing vacuole membrane nuclear membrane Golgi cisterna membrane cellular response to interferon-beta identical protein binding defense response to protozoan innate immune response defense response to Gram-negative bacterium uc008fad.1 uc008fad.2 uc008fad.3 uc008fad.4 uc008fad.5 
ENSMUST00000032476.11 Slc2a3 ENSMUST00000032476.11 solute carrier family 2 (facilitated glucose transporter), member 3, transcript variant 5 (from RefSeq NM_011401.5) ENSMUST00000032476.1 ENSMUST00000032476.10 ENSMUST00000032476.2 ENSMUST00000032476.3 ENSMUST00000032476.4 ENSMUST00000032476.5 ENSMUST00000032476.6 ENSMUST00000032476.7 ENSMUST00000032476.8 ENSMUST00000032476.9 NM_011401 Q3TPL8 Q3TPL8_MOUSE Slc2a3 uc009dpq.1 uc009dpq.2 uc009dpq.3 Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Reaction=D-galactose(in) = D-galactose(out); Xref=Rhea:RHEA:34915, ChEBI:CHEBI:4139; Evidence=; Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, ChEBI:CHEBI:4167; Evidence= Interacts with SMIM43; the interaction may promote SLC2A3- mediated glucose transport to meet the energy needs of mesendoderm differentiation. Cell membrane ; Multi-pass membrane protein Cell projection mbrane ; Multi-pass membrane protein Perikaryon Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. glucose transmembrane transporter activity carbohydrate transport membrane integral component of membrane transmembrane transporter activity transmembrane transport glucose transmembrane transport uc009dpq.1 uc009dpq.2 uc009dpq.3 
ENSMUST00000032477.6 Necap1 ENSMUST00000032477.6 NECAP endocytosis associated 1, transcript variant 2 (from RefSeq NR_156733.1) ENSMUST00000032477.1 ENSMUST00000032477.2 ENSMUST00000032477.3 ENSMUST00000032477.4 ENSMUST00000032477.5 NECP1_MOUSE NR_156733 Q3TH13 Q78JW3 Q8C4P1 Q9CR95 uc009dpt.1 uc009dpt.2 uc009dpt.3 Involved in endocytosis. Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with the GAE domain proteins GGA1, GGA2 and GGA3. Q9CR95; P98078: Dab2; NbExp=2; IntAct=EBI-7592476, EBI-1391846; Q9CR95; Q8K285: Fcho1; NbExp=2; IntAct=EBI-7592476, EBI-16078916; Q9CR95; O08838: Amph; Xeno; NbExp=8; IntAct=EBI-7592476, EBI-80080; Q9CR95; P49418: AMPH; Xeno; NbExp=6; IntAct=EBI-7592476, EBI-7121510; Q9CR95; P63010: AP2B1; Xeno; NbExp=2; IntAct=EBI-7592476, EBI-432924; Q9CR95; O08839: Bin1; Xeno; NbExp=9; IntAct=EBI-7592476, EBI-80095; Q9CR95; O00291: HIP1; Xeno; NbExp=3; IntAct=EBI-7592476, EBI-473886; Q9CR95; O60641: SNAP91; Xeno; NbExp=2; IntAct=EBI-7592476, EBI-1105187; Cytoplasmic vesicle, clathrin-coated vesicle membrane Cell membrane Note=Colocalizes with AP-2 at the plasma membrane. Expressed primarily in brain (at protein level). Expressed in the brain and spinal cord at 14.5 dpc (at protein level). The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself. The WXXF motif 1, which is preceded by an acidic residue and has a glycine in second position mediates specific interaction with AP-1. The WXXF motif 2, which is followed by the C-terminal carboxyl group negative charge, allows specific interaction with AP-2. Belongs to the NECAP family. protein binding plasma membrane clathrin-coated pit endocytosis protein transport membrane clathrin vesicle coat clathrin-coated vesicle membrane cytoplasmic vesicle uc009dpt.1 uc009dpt.2 uc009dpt.3 
ENSMUST00000032479.11 Pianp ENSMUST00000032479.11 PILR alpha associated neural protein, transcript variant 1 (from RefSeq NM_175696.4) ENSMUST00000032479.1 ENSMUST00000032479.10 ENSMUST00000032479.2 ENSMUST00000032479.3 ENSMUST00000032479.4 ENSMUST00000032479.5 ENSMUST00000032479.6 ENSMUST00000032479.7 ENSMUST00000032479.8 ENSMUST00000032479.9 NM_175696 PIANP_MOUSE Panp Q3UFR0 Q6P1B3 Q71A40 Q8BHU8 uc009dst.1 uc009dst.2 uc009dst.3 uc009dst.4 uc009dst.5 uc009dst.6 Acts as a ligand for PILRA in neuronal tissues, where it may be involved in immune regulation. Membrane ; Single-pass type I membrane protein Mainly expressed in brain and spinal cord. Weak expression also detected in heart, kidney, spleen and lymph node. Virtually no expression detected in liver and embryo relative to brain. O-glycosylation at Thr-136 is essential for recognition by PILRA. Sequence=AAQ11190.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence=; molecular_function adherens junction biological_process membrane integral component of membrane basolateral plasma membrane regulation of immune response uc009dst.1 uc009dst.2 uc009dst.3 uc009dst.4 uc009dst.5 uc009dst.6 
ENSMUST00000032480.14 Ing4 ENSMUST00000032480.14 inhibitor of growth family, member 4, transcript variant 1 (from RefSeq NM_133345.2) ENSMUST00000032480.1 ENSMUST00000032480.10 ENSMUST00000032480.11 ENSMUST00000032480.12 ENSMUST00000032480.13 ENSMUST00000032480.2 ENSMUST00000032480.3 ENSMUST00000032480.4 ENSMUST00000032480.5 ENSMUST00000032480.6 ENSMUST00000032480.7 ENSMUST00000032480.8 ENSMUST00000032480.9 ING4_MOUSE NM_133345 Q8C0D7 Q8C1S7 Q8K3Q5 Q8K3Q6 Q8K3Q7 Q9D7F9 uc009dtd.1 uc009dtd.2 uc009dtd.3 Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (PubMed:11888890). Homodimer. Component of the HBO1 complex composed of KAT7/HBO1, MEAF6, ING4 or ING5, and one scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE scaffold (JADE1, JADE2 and JADE3) mediate acetylation of histone H4. Interacts with H3K4me3 and to a lesser extent with H3K4me2, the interaction augments KAT7/HBO1 acetylation activity on H3 tails. Interacts with EP300, RELA and TP53; these interactions may be indirect. Interacts with EGLN1. [Isoform 3]: Interacts with BCL2A1. [Isoform 4]: Interacts with BCL2A1. [Isoform 5]: Interacts with BCL2A1. Q8C0D7; P22605: Rarb; NbExp=3; IntAct=EBI-645598, EBI-2903247; Nucleus Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8C0D7-1; Sequence=Displayed; Name=2; Synonyms=mINGh-M ; IsoId=Q8C0D7-2; Sequence=VSP_012521, VSP_012522; Name=3; Synonyms=mINGh-L2 ; IsoId=Q8C0D7-3; Sequence=VSP_012521, VSP_012522, VSP_012526, VSP_012527; Name=4; Synonyms=mINGh-L ; IsoId=Q8C0D7-4; Sequence=VSP_012521, VSP_012522, VSP_012523; Name=5; Synonyms=mINGh-S ; IsoId=Q8C0D7-5; Sequence=VSP_012520, VSP_012524, VSP_012525; Isoform 2, isoform 3, isoform 4 and isoform 5 are expressed in the mammary gland, ovary, spleen and muscle. [Isoform 2]: Expressed in the mammary gland, ovary, spleen and muscle. [Isoform 3]: Expressed in the mammary gland, ovary, spleen and muscle. [Isoform 4]: Expressed in the mammary gland, ovary, spleen and muscle. [Isoform 5]: Expressed in the mammary gland, ovary, spleen and muscle. The PHD-type zinc finger mediates the binding to H3K4me3. The N-terminal coiled-coil domain mediates homodimerization. Citrullination by PADI4 within the nuclear localization signal disrupts the interaction with p53 and increases susceptibility to degradation. [Isoform 2]: May be due to a competing donor splice site. [Isoform 3]: May be due to intron retention. [Isoform 4]: May be due to intron retention. [Isoform 5]: May be due to a competing acceptor splice site. Belongs to the ING family. Sequence=BAC25009.1; Type=Frameshift; Evidence=; histone acetyltransferase complex transcription coactivator activity protein binding nucleus cytosol DNA replication chromatin organization protein acetylation apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cell cycle cell cycle arrest negative regulation of cell proliferation histone acetylation methylated histone binding positive regulation of apoptotic process histone H3 acetylation histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K12 acetylation intermediate filament cytoskeleton negative regulation of transcription, DNA-templated negative regulation of growth metal ion binding positive regulation of nucleic acid-templated transcription histone H4-K16 acetylation uc009dtd.1 uc009dtd.2 uc009dtd.3 
ENSMUST00000032485.7 Mrpl51 ENSMUST00000032485.7 mitochondrial ribosomal protein L51 (from RefSeq NM_025595.3) ENSMUST00000032485.1 ENSMUST00000032485.2 ENSMUST00000032485.3 ENSMUST00000032485.4 ENSMUST00000032485.5 ENSMUST00000032485.6 Mrp64 NM_025595 Q9CPY1 Q9CWZ9 RM51_MOUSE uc009dtw.1 uc009dtw.2 uc009dtw.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity). Interacts with OXA1L (By similarity). Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mL51 family. structural constituent of ribosome mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit ribosome translation mitochondrial translation uc009dtw.1 uc009dtw.2 uc009dtw.3 
ENSMUST00000032486.13 Cd27 ENSMUST00000032486.13 CD27 antigen, transcript variant 1 (from RefSeq NM_001033126.2) Cd27 ENSMUST00000032486.1 ENSMUST00000032486.10 ENSMUST00000032486.11 ENSMUST00000032486.12 ENSMUST00000032486.2 ENSMUST00000032486.3 ENSMUST00000032486.4 ENSMUST00000032486.5 ENSMUST00000032486.6 ENSMUST00000032486.7 ENSMUST00000032486.8 ENSMUST00000032486.9 NM_001033126 Q3U4X0 Q3U4X0_MOUSE Tnfrsf7 uc009duc.1 uc009duc.2 uc009duc.3 Lacks conserved residue(s) required for the propagation of feature annotation. transmembrane signaling receptor activity membrane integral component of membrane cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to ethanol positive regulation of B cell differentiation positive regulation of T cell differentiation extrinsic apoptotic signaling pathway uc009duc.1 uc009duc.2 uc009duc.3 
ENSMUST00000032487.14 Vamp1 ENSMUST00000032487.14 vesicle-associated membrane protein 1, transcript variant 1 (from RefSeq NM_009496.3) ENSMUST00000032487.1 ENSMUST00000032487.10 ENSMUST00000032487.11 ENSMUST00000032487.12 ENSMUST00000032487.13 ENSMUST00000032487.2 ENSMUST00000032487.3 ENSMUST00000032487.4 ENSMUST00000032487.5 ENSMUST00000032487.6 ENSMUST00000032487.7 ENSMUST00000032487.8 ENSMUST00000032487.9 NM_009496 Q62442 Q6PFF3 Q810K6 Syb1 VAMP1_MOUSE uc009dtx.1 uc009dtx.2 uc009dtx.3 Involved in the targeting and/or fusion of transport vesicles to their target membrane. Interacts with VAPA and VAPB. [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type IV membrane protein Synapse, synaptosome [Isoform 2]: Cytoplasmic vesicle membrane ; Single-pass type IV membrane protein Synapse, synaptosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q62442-1; Sequence=Displayed; Name=2; IsoId=Q62442-2; Sequence=VSP_029186; Highly expressed in the zona incerta and rostral periolivary region of the brain. Other neuroanatomical regions show negligible expression. Expressed in the retina, expression observed in the outer segments of the photoreceptors, in the outer and inner plexiform layers, and in a subset of ganglion cells. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 68-Arg-|-Ala-69 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets. Note=Defects in Vamp1 are the cause of lethal-wasting (lew) phenotype, a mice mutant strain. The lew mutant phenotype is inherited in an autosomal recessive manner and manifests with neurological signs. Lew animals are characterized by a general lack of movement and wasting, eventually leading to death before weaning. The affected animals die near postnatal day 15 (P15). By P10, the mutants are noticeably immobile and lay on their side. Before this stage, mutants can be identified by a failure to attempt to right themselves. In earlier perinatal stages, the mutants are of normal size and difficult to discern from their normal littermates. The affected mice can move their limbs although not in any purposeful manner. No protein is detectable in homozygous mutant animals. Belongs to the synaptobrevin family. mitochondrion cell surface membrane integral component of membrane synaptic vesicle priming vesicle-mediated transport cell junction integral component of synaptic vesicle membrane cytoplasmic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle neuromuscular junction regulation of synaptic vesicle fusion to presynaptic membrane SNARE complex assembly specific granule membrane neuron projection synapse tertiary granule membrane presynapse glutamatergic synapse uc009dtx.1 uc009dtx.2 uc009dtx.3 
ENSMUST00000032489.8 Ltbr ENSMUST00000032489.8 lymphotoxin B receptor (from RefSeq NM_010736.5) ENSMUST00000032489.1 ENSMUST00000032489.2 ENSMUST00000032489.3 ENSMUST00000032489.4 ENSMUST00000032489.5 ENSMUST00000032489.6 ENSMUST00000032489.7 NM_010736 P50284 TNR3_MOUSE Tnfcr Tnfrsf3 uc009duj.1 uc009duj.2 uc009duj.3 Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs (By similarity). Self-associates (By similarity). Associates with TRAF5. Associates with TRAF3 and TRAF4 (By similarity). P50284; P39429: Traf2; NbExp=3; IntAct=EBI-647023, EBI-520016; P50284; O43557: TNFSF14; Xeno; NbExp=2; IntAct=EBI-647023, EBI-524131; Membrane; Single-pass type I membrane protein. protein binding Golgi apparatus plasma membrane apoptotic process immune response membrane integral component of membrane ubiquitin protein ligase binding identical protein binding myeloid dendritic cell differentiation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade hematopoietic or lymphoid organ development lymph node development cellular response to mechanical stimulus positive regulation of extrinsic apoptotic signaling pathway uc009duj.1 uc009duj.2 uc009duj.3 
ENSMUST00000032491.15 Tnfrsf1a ENSMUST00000032491.15 tumor necrosis factor receptor superfamily, member 1a (from RefSeq NM_011609.4) ENSMUST00000032491.1 ENSMUST00000032491.10 ENSMUST00000032491.11 ENSMUST00000032491.12 ENSMUST00000032491.13 ENSMUST00000032491.14 ENSMUST00000032491.2 ENSMUST00000032491.3 ENSMUST00000032491.4 ENSMUST00000032491.5 ENSMUST00000032491.6 ENSMUST00000032491.7 ENSMUST00000032491.8 ENSMUST00000032491.9 NM_011609 Q3U479 Q3U479_MOUSE Tnfrsf1a uc009dul.1 uc009dul.2 uc009dul.3 uc009dul.4 This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mice lacking a functional copy of this gene exhibit impaired immune function. [provided by RefSeq, Sep 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L26349.1, X57796.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Single-pass type I membrane protein Golgi apparatus membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. Golgi membrane tumor necrosis factor-activated receptor activity extracellular space prostaglandin metabolic process inflammatory response signal transduction membrane integral component of membrane tumor necrosis factor-mediated signaling pathway positive regulation of tyrosine phosphorylation of STAT protein tumor necrosis factor binding positive regulation of I-kappaB kinase/NF-kappaB signaling receptor complex membrane raft positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response cellular response to mechanical stimulus protein localization to plasma membrane regulation of establishment of endothelial barrier uc009dul.1 uc009dul.2 uc009dul.3 uc009dul.4 
ENSMUST00000032492.9 Cd9 ENSMUST00000032492.9 CD9 antigen (from RefSeq NM_007657.4) CD9_MOUSE Cd9 ENSMUST00000032492.1 ENSMUST00000032492.2 ENSMUST00000032492.3 ENSMUST00000032492.4 ENSMUST00000032492.5 ENSMUST00000032492.6 ENSMUST00000032492.7 ENSMUST00000032492.8 NM_007657 P40240 Q3U9W0 uc009dun.1 uc009dun.2 uc009dun.3 Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:10700183, PubMed:10634790, PubMed:10634791, PubMed:14715942). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (PubMed:10700183, PubMed:10634790, PubMed:10634791, PubMed:21690351). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (PubMed:23575678). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (PubMed:12796480). Acts as a receptor for PSG17 (PubMed:11805154). Involved in platelet activation and aggregation (PubMed:14715942). Regulates paranodal junction formation (PubMed:14715942). Involved in cell adhesion, cell motility and tumor metastasis (By similarity). Also regulates integrin-dependent migration of macrophages, particularly relevant for inflammatory response in the lung (PubMed:18662991). Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family (By similarity). Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (By similarity). Interacts with integrin ITGA6:ITGB1; interaction takes place in oocytes and is involved in sperm-egg fusion (PubMed:10634791). Part of integrin-tetraspanin complexes composed of CD81, beta-1 and beta-2 integrins in the membrane of monocyte/macrophages (By similarity). Interacts with CD63; identified in a complex with CD63 and ITGB3 (By similarity). Associates with CR2/CD21 and with PTGFRN/CD9P1 (By similarity). Part of a complex composed of CD9, CD81, PTGFRN and IGSF8 (PubMed:23575678). Interacts directly with IGSF8 (By similarity). Interacts with PDPN; this interaction is homophilic and attenuates platelet aggregation and pulmonary metastasis induced by PDPN (By similarity). Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Secreted, extracellular exosome Note=Present at the cell surface of oocytes (PubMed:10518536, PubMed:10634791, PubMed:23213457). Accumulates in the adhesion area between the sperm and egg following interaction between IZUMO1 and its receptor IZUMO1R/JUNO (PubMed:25209248). Expressed predominantly in the peripheral nervous system (PubMed:14715942). Highly expressed in oocytes and blastocysts (at protein level) (PubMed:10518536, PubMed:10634790, PubMed:10634791, PubMed:23213457). Expression is also observed on follicular oocytes in the ovary, whereas no expression is found on follicular cells (at protein level) (PubMed:10518536, PubMed:10634790). Expressed in skeletal muscle mainly in endothelial cells of endomysial capillaries, in satellite cells and myoblasts (at protein level). Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion. Knockout mice are healthy, but females display severely reduced fertility (PubMed:10634790, PubMed:10634791). Oocyte maturation and ovulation are normal and female infertility is caused by defects in sperm-egg fusion (PubMed:10634790, PubMed:10634791). Wild type sperm penetrates the zona pellucida, binds to the oolema but the membranes fail to fuse (PubMed:10634790, PubMed:10634791). The infertility is overcome by intracytoplasmic sperm injection, and embryos develop normally (PubMed:10634790, PubMed:10634791). Eggs show reduced ability for strong sperm adhesion, and sperm accumulate in the perivitelline space, only transiently binding to the egg surface (PubMed:21690351). In response to notexin-induced acute myoinjury, mutant mice display abnormal muscle regeneration characterized by typical giant distrophic myofibres (PubMed:23575678). These mice spontaneously develop multinucleated giant cells (MGCs) and show enhanced osteoclastogenesis when compared to wild-type littermates (PubMed:12796480). CD81 and CD9 double knockout mice develop pulmonary emphysema, reminiscent of chronic obstructive pulmonary disease in human (PubMed:18662991). Belongs to the tetraspanin (TM4SF) family. integrin binding protein binding extracellular region plasma membrane integral component of plasma membrane cell adhesion single fertilization fusion of sperm to egg plasma membrane brain development negative regulation of cell proliferation response to water deprivation external side of plasma membrane cell surface oligodendrocyte development myoblast fusion involved in skeletal muscle regeneration membrane integral component of membrane apical plasma membrane paranodal junction assembly receptor internalization macromolecular complex sperm-egg recognition negative regulation of cellular component movement extracellular exosome cellular response to low-density lipoprotein particle stimulus negative regulation of platelet aggregation regulation of macrophage migration uc009dun.1 uc009dun.2 uc009dun.3 
ENSMUST00000032497.7 D6Wsu163e ENSMUST00000032497.7 DNA segment, Chr 6, Wayne State University 163, expressed, transcript variant 1 (from RefSeq NM_138594.4) CL004_MOUSE ENSMUST00000032497.1 ENSMUST00000032497.2 ENSMUST00000032497.3 ENSMUST00000032497.4 ENSMUST00000032497.5 ENSMUST00000032497.6 NM_138594 Q3UVK4 Q91YN0 uc009dvn.1 uc009dvn.2 uc009dvn.3 Plays a role in mast cell degranulation. Cytoplasm molecular_function cellular_component cytoplasm biological_process regulation of mast cell degranulation uc009dvn.1 uc009dvn.2 uc009dvn.3 
ENSMUST00000032500.9 Prmt8 ENSMUST00000032500.9 protein arginine N-methyltransferase 8, transcript variant 2 (from RefSeq NR_157230.1) ANM8_MOUSE ENSMUST00000032500.1 ENSMUST00000032500.2 ENSMUST00000032500.3 ENSMUST00000032500.4 ENSMUST00000032500.5 ENSMUST00000032500.6 ENSMUST00000032500.7 ENSMUST00000032500.8 Hrmt1l4 NR_157230 Prmt8 Q6PAK3 Q7M6Z2 uc009dwb.1 uc009dwb.2 uc009dwb.3 uc009dwb.4 S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer. Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS. Reaction=L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48100, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:11990, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65280; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48101; Evidence=; Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA- COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48097; Evidence=; Homodimer. Tetramer; individual homodimers associates to form a homotetramer. Homooctamer; individual homodimers associates to form a homooctamer and homooligomerization is required for proper localization to the cell membrane. Heterodimer with PRMT1; heterodimerization may recruit PRMT1 activity to the plasma membrane. Interacts with PRMT2 (via the SH3 domain). Interacts with FYN (via the SH3 domain). Interacts with EWS; independently of EWS methylation status. Cell membrane ; Lipid-anchor ; Cytoplasmic side Brain-specific. Only expressed in neurons, especially in the somatosensory and limbic systems, and a part of motor system. Highly expressed in all of the regions related to general somatosensory system. Expressed in most of the relay nuclei intervening the special somatosensory system, such as the auditory, visual and vestibular systems. Also present in forebrain limbic areas and thalamic nuclei relevant to limbic areas and in areas related to the motor system, such as the caudate putamen, Purkinje cells, inferior olivary nucleus and cerebellar nuclei. The SH3-binding motifs mediate the interaction with SH3 domain- containing proteins such as PRMT2 and FYN, possibly leading to displace the N-terminal domain and activate the protein. The N-terminal region (1-60) inhibits the arginine N- methyltransferase activity. Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT8 subfamily. Sequence=AAH60250.1; Type=Erroneous initiation; Evidence=; plasma membrane protein methylation methyltransferase activity histone-arginine N-methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity membrane histone methylation transferase activity peptidyl-arginine methylation peptidyl-arginine methylation, to asymmetrical-dimethyl arginine methylation histone arginine methylation protein-arginine omega-N monomethyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity identical protein binding protein homodimerization activity protein heterodimerization activity protein homooligomerization anchored component of the cytoplasmic side of the plasma membrane S-adenosyl-L-methionine binding nucleus uc009dwb.1 uc009dwb.2 uc009dwb.3 uc009dwb.4 
ENSMUST00000032501.6 Tspan11 ENSMUST00000032501.6 tetraspanin 11 (from RefSeq NM_026743.3) ENSMUST00000032501.1 ENSMUST00000032501.2 ENSMUST00000032501.3 ENSMUST00000032501.4 ENSMUST00000032501.5 NM_026743 Q9D1D1 TSN11_MOUSE uc009ecn.1 uc009ecn.2 uc009ecn.3 Membrane ; Multi-pass membrane protein Belongs to the tetraspanin (TM4SF) family. molecular_function integral component of plasma membrane membrane integral component of membrane cell migration uc009ecn.1 uc009ecn.2 uc009ecn.3 
ENSMUST00000032508.11 Fkbp4 ENSMUST00000032508.11 FK506 binding protein 4 (from RefSeq NM_010219.4) ENSMUST00000032508.1 ENSMUST00000032508.10 ENSMUST00000032508.2 ENSMUST00000032508.3 ENSMUST00000032508.4 ENSMUST00000032508.5 ENSMUST00000032508.6 ENSMUST00000032508.7 ENSMUST00000032508.8 ENSMUST00000032508.9 FKBP4_MOUSE Fkpb52 NM_010219 P30416 Q3TVC9 uc009edr.1 uc009edr.2 uc009edr.3 Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Inhibited by FK506. Homodimer (By similarity). Interacts with GLMN (By similarity). Associates with HSP90AA1 and HSPA1A/HSPA1B in steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl- CoA alpha-hydroxylase (PHYH). Interacts with NR3C1 and dynein. Interacts with HSF1 in the HSP90 complex. Associates with tubulin. Interacts with MAPT/TAU (By similarity). Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent. Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction. Interacts with dynein; contributes to NR3C1 transport to the nucleus. P30416; P06537: Nr3c1; NbExp=3; IntAct=EBI-492746, EBI-492753; Cytoplasm, cytosol Mitochondrion Nucleus Cytoplasm, cytoskeleton Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor. Colocalized with MAPT/TAU in the distal part of the primary cortical neurons. The PPIase activity is mainly due to the first PPIase FKBP-type domain (1-138 AA). The C-terminal region (AA 375-458) is required to prevent tubulin polymerization. The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400. The TPR repeats mediate mitochondrial localization. Phosphorylation by CK2 results in loss of HSP90 binding activity. Sequence=CAA34914.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAA34914.1; Type=Frameshift; Evidence=; protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity protein binding ATP binding GTP binding FK506 binding nucleus nucleoplasm cytoplasm mitochondrion cytosol cytoskeleton microtubule steroid hormone receptor complex assembly copper ion transport embryo implantation negative regulation of neuron projection development isomerase activity androgen receptor signaling pathway prostate gland development heat shock protein binding negative regulation of microtubule polymerization or depolymerization negative regulation of microtubule polymerization protein complex localization copper-dependent protein binding macromolecular complex glucocorticoid receptor binding neuron projection neuronal cell body axonal growth cone male sex differentiation tau protein binding perinuclear region of cytoplasm reproductive structure development phosphoprotein binding chaperone-mediated protein folding uc009edr.1 uc009edr.2 uc009edr.3 
ENSMUST00000032512.15 Klrb1a ENSMUST00000032512.15 killer cell lectin-like receptor subfamily B member 1A, transcript variant 1 (from RefSeq NM_010737.3) ENSMUST00000032512.1 ENSMUST00000032512.10 ENSMUST00000032512.11 ENSMUST00000032512.12 ENSMUST00000032512.13 ENSMUST00000032512.14 ENSMUST00000032512.2 ENSMUST00000032512.3 ENSMUST00000032512.4 ENSMUST00000032512.5 ENSMUST00000032512.6 ENSMUST00000032512.7 ENSMUST00000032512.8 ENSMUST00000032512.9 G5E882 G5E882_MOUSE Klrb1a NM_010737 uc009eej.1 uc009eej.2 uc009eej.3 Membrane ; Single- pass type II membrane protein membrane integral component of membrane carbohydrate binding uc009eej.1 uc009eej.2 uc009eej.3 
ENSMUST00000032518.7 Clec2h ENSMUST00000032518.7 C-type lectin domain family 2, member h (from RefSeq NM_053165.5) CLC2H_MOUSE Clrf ENSMUST00000032518.1 ENSMUST00000032518.2 ENSMUST00000032518.3 ENSMUST00000032518.4 ENSMUST00000032518.5 ENSMUST00000032518.6 NM_053165 Q78IZ7 Q8C1T8 Q924B2 uc009eek.1 uc009eek.2 uc009eek.3 Lectin-type cell surface receptor. Cell membrane ; Single-pass type II membrane protein Detected in ileum, liver, kidney and in IL2- activated natural killer cells. Sequence=AAK70358.1; Type=Erroneous initiation; Evidence=; transmembrane signaling receptor activity plasma membrane integral component of plasma membrane cellular defense response membrane integral component of membrane carbohydrate binding natural killer cell lectin-like receptor binding uc009eek.1 uc009eek.2 uc009eek.3 
ENSMUST00000032519.12 Clec2i ENSMUST00000032519.12 C-type lectin domain family 2, member i, transcript variant 2 (from RefSeq NM_020257.2) CLC2I_MOUSE Clrg Dcl1 ENSMUST00000032519.1 ENSMUST00000032519.10 ENSMUST00000032519.11 ENSMUST00000032519.2 ENSMUST00000032519.3 ENSMUST00000032519.4 ENSMUST00000032519.5 ENSMUST00000032519.6 ENSMUST00000032519.7 ENSMUST00000032519.8 ENSMUST00000032519.9 NM_020257 Ocilrp2 Q1AFZ2 Q7TSP6 Q7TSP7 Q8BFR3 Q924B1 Q9WVF9 uc009eeu.1 uc009eeu.2 uc009eeu.3 uc009eeu.4 Inhibits osteoclast formation. Receptor for KLRB1F. Enhances T-cell activation. Plays a role in splenocyte activation, T-cell responses and IL-2 production. Cell membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9WVF9-1; Sequence=Displayed; Name=2; Synonyms=Lymphoid-derived C-type lectin-1b, LCL-1b; IsoId=Q9WVF9-2; Sequence=VSP_030532; Name=3; Synonyms=Lymphoid-derived C-type lectin-1a, LCL-1a; IsoId=Q9WVF9-3; Sequence=VSP_030531, VSP_030532; Name=4; Synonyms=Lymphoid-derived C-type lectin-1c, LCL-1c; IsoId=Q9WVF9-4; Sequence=VSP_030530; Detected in osteoblasts, growth plate chondrocytes and skeletal muscle overlying the bone (at protein level). Detected in spleen, B-cells, dendritic cells, thymus, and in IL2-activated natural killer cells. Up-regulated in CD4(+) T-cells upon stimulation with CD3- ligands. Up-regulated in cultured calvarial osteoblasts by 1,25- dihydroxyvitamin D3. Constitutively expressed in cultured bone marrow cells during osteoclast formation. Sequence=AAK70359.1; Type=Erroneous initiation; Evidence=; membrane raft assembly transmembrane signaling receptor activity protein binding plasma membrane external side of plasma membrane cell surface membrane integral component of membrane carbohydrate binding regulation of actin filament polymerization regulation of T cell proliferation receptor clustering regulation of interleukin-2 biosynthetic process negative regulation of osteoclast differentiation natural killer cell lectin-like receptor binding T cell receptor signaling pathway positive regulation of immunological synapse formation uc009eeu.1 uc009eeu.2 uc009eeu.3 uc009eeu.4 
ENSMUST00000032539.14 Slc27a5 ENSMUST00000032539.14 solute carrier family 27 (fatty acid transporter), member 5 (from RefSeq NM_009512.2) A6H6C1 Acsb Acsvl6 ENSMUST00000032539.1 ENSMUST00000032539.10 ENSMUST00000032539.11 ENSMUST00000032539.12 ENSMUST00000032539.13 ENSMUST00000032539.2 ENSMUST00000032539.3 ENSMUST00000032539.4 ENSMUST00000032539.5 ENSMUST00000032539.6 ENSMUST00000032539.7 ENSMUST00000032539.8 ENSMUST00000032539.9 Fatp5 NM_009512 O88694 Q4LDG0 Q91VD5 S27A5_MOUSE Vlacsr uc009fey.1 uc009fey.2 uc009fey.3 uc009fey.4 uc009fey.5 Mediates the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes (PubMed:16618416). Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (By similarity). Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:16618417). Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (By similarity). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5- beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta- cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (By similarity). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (PubMed:16618416, PubMed:16618417). Reaction=a fatty acid(in) = a fatty acid(out); Xref=Rhea:RHEA:38879, ChEBI:CHEBI:28868; Evidence=; Reaction=ATP + cholate + CoA = AMP + choloyl-CoA + diphosphate; Xref=Rhea:RHEA:23532, ChEBI:CHEBI:29747, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57373, ChEBI:CHEBI:456215; EC=6.2.1.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23533; Evidence=; Reaction=(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan- 26-oyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:22976, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58677, ChEBI:CHEBI:58734, ChEBI:CHEBI:456215; EC=6.2.1.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22977; Evidence=; Reaction=ATP + chenodeoxycholate + CoA = AMP + chenodeoxycholoyl-CoA + diphosphate; Xref=Rhea:RHEA:43764, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:36234, ChEBI:CHEBI:57287, ChEBI:CHEBI:62989, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43765; Evidence=; Reaction=ATP + CoA + deoxycholate = AMP + deoxycholoyl-CoA + diphosphate; Xref=Rhea:RHEA:47128, ChEBI:CHEBI:23614, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58810, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47129; Evidence=; Reaction=ATP + CoA + lithocholate = AMP + diphosphate + lithocholoyl- CoA; Xref=Rhea:RHEA:47136, ChEBI:CHEBI:29744, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:87438, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47137; Evidence=; Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537; Evidence=; Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616, ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640; Evidence=; Reaction=ATP + CoA + hexacosanoate = AMP + diphosphate + hexacosanoyl- CoA; Xref=Rhea:RHEA:43748, ChEBI:CHEBI:30616, ChEBI:CHEBI:31013, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:64868, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43749; Evidence=; Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl- CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422; Evidence=; Reaction=ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl- CoA; Xref=Rhea:RHEA:33615, ChEBI:CHEBI:25629, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33616; Evidence=; Reaction=ATP + CoA + eicosanoate = AMP + diphosphate + eicosanoyl-CoA; Xref=Rhea:RHEA:46208, ChEBI:CHEBI:30616, ChEBI:CHEBI:32360, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46209; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Microsome Cell membrane ; Multi-pass membrane protein Liver-specific (at protein level) (PubMed:16618416, PubMed:9642112). In liver expressed in a periportal distribution (PubMed:11980911). Mice exhibit a severe bile acid conjugation defect (PubMed:16618417). Display a significant reduction in both liver lipid uptake and content and show a redistribution of lipids away from the liver to other tissues (PubMed:16618416). Hepatocytes show significantly reduced long-chain fatty acids (LCFA) uptake (PubMed:16618416). Belongs to the ATP-dependent AMP-binding enzyme family. very long-chain fatty acid metabolic process nucleotide binding long-chain fatty acid metabolic process catalytic activity long-chain fatty acid-CoA ligase activity long-chain fatty acid transporter activity ATP binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process triglyceride mobilization bile acid biosynthetic process bile acid metabolic process basal plasma membrane fatty acid transporter activity fatty acid transport plasma membrane long-chain fatty acid transport membrane integral component of membrane ligase activity integral component of endoplasmic reticulum membrane very long-chain fatty acid-CoA ligase activity macromolecular complex intracellular membrane-bounded organelle macromolecular complex binding ketone body biosynthetic process cholate-CoA ligase activity uc009fey.1 uc009fey.2 uc009fey.3 uc009fey.4 uc009fey.5 
ENSMUST00000032541.5 2900092C05Rik ENSMUST00000032541.5 RIKEN cDNA 2900092C05 gene (from RefSeq NM_028434.3) 2900092C05Rik ENSMUST00000032541.1 ENSMUST00000032541.2 ENSMUST00000032541.3 ENSMUST00000032541.4 NM_028434 Q5I0V9 Q5I0V9_MOUSE uc009fed.1 uc009fed.2 uc009fed.3 uc009fed.4 uc009fed.5 molecular_function biological_process membrane integral component of membrane uc009fed.1 uc009fed.2 uc009fed.3 uc009fed.4 uc009fed.5 
ENSMUST00000032551.8 Zik1 ENSMUST00000032551.8 zinc finger protein interacting with K protein 1 (from RefSeq NM_009577.3) ENSMUST00000032551.1 ENSMUST00000032551.2 ENSMUST00000032551.3 ENSMUST00000032551.4 ENSMUST00000032551.5 ENSMUST00000032551.6 ENSMUST00000032551.7 NM_009577 P70405 Q80YP6 ZIK1_MOUSE uc009fdf.1 uc009fdf.2 uc009fdf.3 May be a transcriptional repressor. Interacts with HNRPK. Nucleus Expressed in ovary and liver, and at lower levels in brain and muscle. Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009fdf.1 uc009fdf.2 uc009fdf.3 
ENSMUST00000032559.17 Rtn2 ENSMUST00000032559.17 reticulon 2 (Z-band associated protein), transcript variant B (from RefSeq NM_013648.6) ENSMUST00000032559.1 ENSMUST00000032559.10 ENSMUST00000032559.11 ENSMUST00000032559.12 ENSMUST00000032559.13 ENSMUST00000032559.14 ENSMUST00000032559.15 ENSMUST00000032559.16 ENSMUST00000032559.2 ENSMUST00000032559.3 ENSMUST00000032559.4 ENSMUST00000032559.5 ENSMUST00000032559.6 ENSMUST00000032559.7 ENSMUST00000032559.8 ENSMUST00000032559.9 NM_013648 Q6IM75 Q6IM75_MOUSE Rtn2 uc009fli.1 uc009fli.2 uc009fli.3 uc009fli.4 Cell membrane, sarcolemma, T-tubule ; Multi-pass membrane protein Cell membrane, sarcolemma ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line Endoplasmic reticulum membrane ; Multi- pass membrane protein mbrane ; Multi-pass membrane protein Sarcoplasmic reticulum membrane ; Multi-pass membrane protein endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane uc009fli.1 uc009fli.2 uc009fli.3 uc009fli.4 
ENSMUST00000032560.6 Ppm1n ENSMUST00000032560.6 protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) (from RefSeq NM_177691.3) ENSMUST00000032560.1 ENSMUST00000032560.2 ENSMUST00000032560.3 ENSMUST00000032560.4 ENSMUST00000032560.5 NM_177691 PPM1N_MOUSE Q8BGL1 uc009flg.1 uc009flg.2 uc009flg.3 Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit. ; Belongs to the PP2C family. magnesium ion binding catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity nucleus cytosol protein dephosphorylation hydrolase activity manganese ion binding negative regulation of I-kappaB kinase/NF-kappaB signaling metal ion binding positive regulation of canonical Wnt signaling pathway uc009flg.1 uc009flg.2 uc009flg.3 
ENSMUST00000032561.9 Vasp ENSMUST00000032561.9 vasodilator-stimulated phosphoprotein, transcript variant 4 (from RefSeq NR_104069.1) ENSMUST00000032561.1 ENSMUST00000032561.2 ENSMUST00000032561.3 ENSMUST00000032561.4 ENSMUST00000032561.5 ENSMUST00000032561.6 ENSMUST00000032561.7 ENSMUST00000032561.8 NR_104069 P70460 Q3TAP0 Q3TCD2 Q3U0C2 Q3UDF1 Q91VD2 Q9R214 VASP_MOUSE uc009fle.1 uc009fle.2 uc009fle.3 uc009fle.4 uc009fle.5 Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity). Homotetramer (By similarity). Interacts with PFN1, PFN2, LPP, ACTN1 and ACTG1. Interacts, via the EVH1 domain, with the Pro-rich regions of ZYX. This interaction is important for targeting to focal adhesions and the formation of actin-rich structures at the apical surface of cells. Interacts, via the EVH1 domain, with the Pro-rich domain of Listeria monocytogenes actA. Interacts with APBB1IP. Interacts, via the Pro-rich domain, with the C-terminal SH3 domain of DNMBP. Interacts weakly with MEFV (By similarity). Cytoplasm Cytoplasm, cytoskeleton Cell junction, focal adhesion Cell junction, tight junction Cell projection, lamellipodium membrane Cell projection, filopodium membrane Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions (By similarity). In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (By similarity). Highly expressed in thymus and spleen. Lower levels in lung, ovary, placenta and fat. Expressed constantly throughout brain development, with lower levels in adulthood. The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization. The WH1 domain mediates interaction with XIRP1. Major substrate for cAMP-dependent (PKA) and cGMP-dependent protein kinase (PKG) in platelets. The preferred site for PKA is Ser- 153, the preferred site for PKG, Ser-235. In ADP-activated platelets, phosphorylation by PKA or PKG/PRKG1 on Ser-153 leads to fibrinogen receptor inhibition. Phosphorylation on Thr-274 requires prior phosphorylation on Ser-153 and Ser-235. In response to phorbol ester (PMA) stimulation, phosphorylated by PKC/PRKCA. In response to thrombin, phosphorylated by both PKC and ROCK1. Phosphorylation at Thr- 274 by AMPK does not require prior phosphorylation at Ser-153 or Ser- 235. Phosphorylation at Ser-153 by PKA is required for localization to the tight junctions in epithelial cells. Phosphorylation modulates F- actin binding, actin filament elongation and platelet activation. Phosphorylation at Ser-318 by AMPK also alters actin filament binding. Carbon monoxide (CO) promotes phosphorylation at Ser-153, while nitric oxide (NO) promotes phosphorylation at Ser-153, but also at Ser-235. Belongs to the Ena/VASP family. Sequence=CAA67108.1; Type=Erroneous gene model prediction; Evidence=; neural tube closure actin binding protein binding profilin binding cytoplasm cytosol cytoskeleton plasma membrane bicellular tight junction focal adhesion axon guidance actin polymerization or depolymerization membrane SH3 domain binding lamellipodium actin cytoskeleton organization cell junction filopodium positive regulation of actin filament polymerization lamellipodium membrane filopodium membrane cell projection protein homotetramerization uc009fle.1 uc009fle.2 uc009fle.3 uc009fle.4 uc009fle.5 
ENSMUST00000032566.3 Qpctl ENSMUST00000032566.3 glutaminyl-peptide cyclotransferase-like (from RefSeq NM_026111.3) ENSMUST00000032566.1 ENSMUST00000032566.2 NM_026111 Q8BH73 Q9D8T5 Q9D8Y3 QPCTL_MOUSE uc009fku.1 uc009fku.2 uc009fku.3 Responsible for the biosynthesis of pyroglutamyl peptides. Reaction=N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl- [peptide] + NH4(+); Xref=Rhea:RHEA:23652, Rhea:RHEA-COMP:11736, Rhea:RHEA-COMP:11846, ChEBI:CHEBI:28938, ChEBI:CHEBI:64722, ChEBI:CHEBI:87215; EC=2.3.2.5; Golgi apparatus membrane ; Single- pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BH73-1; Sequence=Displayed; Name=2; IsoId=Q8BH73-2; Sequence=VSP_027904; Detected in thalamus, hippocampus, brain cortex, cerebellum, kidney, lung and liver, and at low levels in heart and spleen. Belongs to the glutaminyl-peptide cyclotransferase family. It is unclear whether this protein requires a metal cofactor for catalysis. It was originally proposed to be a Zn(2+)-dependent metalloenzyme based on structural similarities to bacterial aminopeptidases and the observation that it can bind Zn(2+) ions, typically in a 1:1 stoichiometry (By similarity). However, a recent study suggests a Zn(2+)-independent catalytic mechanism (By similarity). Golgi membrane Golgi apparatus zinc ion binding membrane integral component of membrane glutaminyl-peptide cyclotransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase metal ion binding uc009fku.1 uc009fku.2 uc009fku.3 
ENSMUST00000032570.14 Dmwd ENSMUST00000032570.14 dystrophia myotonica-containing WD repeat motif, transcript variant 1 (from RefSeq NM_010058.2) DMWD_MOUSE Dm9 E9QLY4 ENSMUST00000032570.1 ENSMUST00000032570.10 ENSMUST00000032570.11 ENSMUST00000032570.12 ENSMUST00000032570.13 ENSMUST00000032570.2 ENSMUST00000032570.3 ENSMUST00000032570.4 ENSMUST00000032570.5 ENSMUST00000032570.6 ENSMUST00000032570.7 ENSMUST00000032570.8 ENSMUST00000032570.9 NM_010058 Q08274 uc012fax.1 uc012fax.2 uc012fax.3 Regulator of the deubiquitinating USP12/DMWD/WDR48 complex. Functions as a cofactor that promotes USP12 enzymatic activity. Component of the USP12/DMWD/WDR48 deubiquitinating complex. Interacts with USP12; promotes its enzymatic activity. Interacts with USP46. Cytoplasm Nucleus Perikaryon Cell projection, dendrite Note=Localizes mainly to the cytoplasm however shuttles between the cytoplasm and nucleus (By similarity). In neurons, shows punctate expression throughout the cell body, nucleus and dendrites. Not detected in axons (PubMed:12691844). Widely expressed in brain where it localizes to the olfactory bulb, forebrain, thalamus, hippocampus, cerebellum, cortex and hypothalamus (at protein level) (PubMed:12691844). Expression seems to be particularly strong in areas of high synaptic density such as the glomerular layer of the olfactory bulb, and mossy fiber terminal fields of the hippocampus (at protein level) (PubMed:12691844). Expressed in retina, with strongest expression in the external and internal plexiform layers (at protein level) (PubMed:12691844). Strongly expressed in brain and testis (PubMed:7633444, PubMed:1302022). Also detected at lower levels in heart, kidney, liver, lung, ovary, uterus, bladder and skeletal muscle (PubMed:7633444, PubMed:1302022). In testis, expression seems to be restricted to secondary spermatocytes (PubMed:1302022). In brain, shows increasing expression levels from postnatal day 7 onwards reaching peak levels by postnatal day 21 (at protein level) (PubMed:12691844). Expression is seen very early in embryogenesis, 9.5 dpc in all parts of the embryo (PubMed:7633444). Mid-gestation embryos (14.5 dpc) show high expression in all neural tissues such as telencephalon, retina and spinal cord (PubMed:7633444). In the 16.5 day old embryo high expression is seen in the neural tissues, like telencephalon and mesencephalon and in the non-neural tissues, such as muscle tissues in the tongue and around the ribs (PubMed:7633444). Sequence=CAA86112.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component nucleus dendrite cell projection perikaryon uc012fax.1 uc012fax.2 uc012fax.3 
ENSMUST00000032573.8 Pglyrp1 ENSMUST00000032573.8 peptidoglycan recognition protein 1 (from RefSeq NM_009402.2) ENSMUST00000032573.1 ENSMUST00000032573.2 ENSMUST00000032573.3 ENSMUST00000032573.4 ENSMUST00000032573.5 ENSMUST00000032573.6 ENSMUST00000032573.7 NM_009402 Pglyrp1 Q4FK86 Q4FK86_MOUSE uc009fjv.1 uc009fjv.2 uc009fjv.3 Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. pattern recognition receptor signaling pathway immune system process zinc ion binding N-acetylmuramoyl-L-alanine amidase activity peptidoglycan catabolic process peptidoglycan receptor activity detection of bacterium killing of cells of other organism peptidoglycan binding innate immune response defense response to Gram-positive bacterium positive regulation of cytolysis in other organism uc009fjv.1 uc009fjv.2 uc009fjv.3 
ENSMUST00000032585.8 Pop4 ENSMUST00000032585.8 processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae), transcript variant 3 (from RefSeq NR_184805.1) ENSMUST00000032585.1 ENSMUST00000032585.2 ENSMUST00000032585.3 ENSMUST00000032585.4 ENSMUST00000032585.5 ENSMUST00000032585.6 ENSMUST00000032585.7 NR_184805 Q3U6V7 Q9CR08 RPP29_MOUSE Rpp29 uc009gkv.1 uc009gkv.2 uc009gkv.3 Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Nucleus, nucleolus Belongs to the eukaryotic/archaeal RNase P protein component 1 family. ribonuclease MRP complex tRNA 5'-leader removal RNA binding ribonuclease P activity ribonuclease activity nucleus nucleolus rRNA processing RNA processing tRNA processing hydrolase activity ribonuclease P complex multimeric ribonuclease P complex ribonuclease P RNA binding RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic ribonuclease MRP activity uc009gkv.1 uc009gkv.2 uc009gkv.3 
ENSMUST00000032597.12 Rpl28 ENSMUST00000032597.12 ribosomal protein L28 (from RefSeq NM_009081.2) ENSMUST00000032597.1 ENSMUST00000032597.10 ENSMUST00000032597.11 ENSMUST00000032597.2 ENSMUST00000032597.3 ENSMUST00000032597.4 ENSMUST00000032597.5 ENSMUST00000032597.6 ENSMUST00000032597.7 ENSMUST00000032597.8 ENSMUST00000032597.9 NM_009081 Q5M9J8 Q5M9J8_MOUSE Rpl28 uc009eys.1 uc009eys.2 uc009eys.3 Belongs to the eukaryotic ribosomal protein eL28 family. structural constituent of ribosome ribosome translation uc009eys.1 uc009eys.2 uc009eys.3 
ENSMUST00000032622.9 Zfp773 ENSMUST00000032622.9 zinc finger protein 773 (from RefSeq NM_029584.1) ENSMUST00000032622.1 ENSMUST00000032622.2 ENSMUST00000032622.3 ENSMUST00000032622.4 ENSMUST00000032622.5 ENSMUST00000032622.6 ENSMUST00000032622.7 ENSMUST00000032622.8 NM_029584 Q9CZ29 Q9CZ29_MOUSE Zfp773 uc009fcj.1 uc009fcj.2 uc009fcj.3 uc009fcj.4 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009fcj.1 uc009fcj.2 uc009fcj.3 uc009fcj.4 
ENSMUST00000032627.5 Tubgcp5 ENSMUST00000032627.5 tubulin, gamma complex component 5, transcript variant 1 (from RefSeq NM_146190.3) ENSMUST00000032627.1 ENSMUST00000032627.2 ENSMUST00000032627.3 ENSMUST00000032627.4 GCP5_MOUSE Kiaa1899 NM_146190 Q3U8X5 Q69Z75 Q8BKN5 Q8BLJ9 Q8C083 uc009hde.1 uc009hde.2 uc009hde.3 Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BKN5-1; Sequence=Displayed; Name=2; IsoId=Q8BKN5-2; Sequence=VSP_032040; Name=3; IsoId=Q8BKN5-3; Sequence=VSP_032041; Belongs to the TUBGCP family. microtubule cytoskeleton organization mitotic cell cycle spindle pole equatorial microtubule organizing center gamma-tubulin complex cytoplasm centrosome microtubule organizing center cytosol cytoskeleton microtubule microtubule nucleation microtubule binding gamma-tubulin ring complex cytoplasmic microtubule organization gamma-tubulin binding spindle assembly meiotic cell cycle interphase microtubule nucleation by interphase microtubule organizing center microtubule minus-end binding uc009hde.1 uc009hde.2 uc009hde.3 
ENSMUST00000032629.16 Cyfip1 ENSMUST00000032629.16 cytoplasmic FMR1 interacting protein 1, transcript variant 2 (from RefSeq NM_011370.3) CYFP1_MOUSE Cyfip1 ENSMUST00000032629.1 ENSMUST00000032629.10 ENSMUST00000032629.11 ENSMUST00000032629.12 ENSMUST00000032629.13 ENSMUST00000032629.14 ENSMUST00000032629.15 ENSMUST00000032629.2 ENSMUST00000032629.3 ENSMUST00000032629.4 ENSMUST00000032629.5 ENSMUST00000032629.6 ENSMUST00000032629.7 ENSMUST00000032629.8 ENSMUST00000032629.9 Kiaa0068 NM_011370 O88558 Q3U7Q7 Q5DU50 Q7TMB8 Q7TSZ5 Q80VN6 Q8CE85 Q99LY1 Shyc Sra1 uc009hdl.1 uc009hdl.2 uc009hdl.3 uc009hdl.4 Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E- FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705). Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. Component of the CYFIP1-EIF4E-FMR1 complex which is composed of CYFIP, EIF4E and FMR1. Interacts with FMR1 but does not bind to related proteins FXR1 or FXR2. Interaction with EIF4E stimulates FMR1 binding. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1L/HEM1 in hematopoietic cells) and WASF2/WAVE2. Interacts with the active GTP-bound form of RAC1. Interacts through its C-terminus with the C-terminus of DPYSL2/CRMP2 which is necessary for DPYSL2-induced axon outgrowth. Interacts with NYAP1, NYAP2 and MYO16. Interacts with TMEM108 (via N-terminus); the interaction associates TMEM108 with the WAVE1 complex (PubMed:27605705). Q7TMB8; P63073: Eif4e; NbExp=5; IntAct=EBI-772928, EBI-2000006; Cytoplasm toplasm, perinuclear region Cell projection, lamellipodium Cell projection, ruffle Synapse, synaptosome Note=Highly expressed in the perinuclear region (PubMed:11438699). Enriched in synaptosomes (PubMed:11438699). Also enriched in membrane ruffles and at the tips of lamellipodia (PubMed:14765121). Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q7TMB8-1; Sequence=Displayed; Name=2 ; IsoId=Q7TMB8-2; Sequence=VSP_052348; Highly expressed in embryonic and adult developing nervous system. Mice display greatly reduced lamellipodium formation in response to growth factor stimulation or aluminum fluoride treatment. Abnormal epithelial morphogenesis in vitro, and cooperation with oncogenic Ras to produce invasive carcinomas in vivo. Belongs to the CYFIP family. Sequence=BAD90235.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA 7-methylguanosine cap binding cell morphogenesis ruffle actin binding protein binding profilin binding cytoplasm mRNA cap binding complex regulation of translation multicellular organism development nervous system development axon guidance regulation of cell shape Rac protein signal transduction lamellipodium cell projection assembly lamellipodium assembly cell junction cell differentiation neuron projection development SCAR complex ruffle organization filopodium tip cellular response to insulin stimulus cell projection neuron projection neuronal cell body terminal bouton dendritic spine dendritic growth cone axonal growth cone translation regulator activity synapse positive regulation of axon extension Rac GTPase binding perinuclear region of cytoplasm axon extension positive regulation of axonogenesis cognition actin filament binding positive regulation of neurotrophin TRK receptor signaling pathway response to electrical stimulus excitatory synapse central region of growth cone peripheral region of growth cone dendrite extension postsynapse modification of synaptic structure regulation of translation at postsynapse, modulating synaptic transmission positive regulation of dendrite development positive regulation of ruffle assembly negative regulation of synaptic vesicle recycling regulation of modification of postsynaptic actin cytoskeleton positive regulation of Arp2/3 complex-mediated actin nucleation uc009hdl.1 uc009hdl.2 uc009hdl.3 uc009hdl.4 
ENSMUST00000032633.12 Oca2 ENSMUST00000032633.12 oculocutaneous albinism II, transcript variant 2 (from RefSeq NR_157030.1) ENSMUST00000032633.1 ENSMUST00000032633.10 ENSMUST00000032633.11 ENSMUST00000032633.2 ENSMUST00000032633.3 ENSMUST00000032633.4 ENSMUST00000032633.5 ENSMUST00000032633.6 ENSMUST00000032633.7 ENSMUST00000032633.8 ENSMUST00000032633.9 NR_157030 P P_MOUSE Q0VBP9 Q62052 uc009hdy.1 uc009hdy.2 uc009hdy.3 Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation. One of the components of the mammalian pigmentary system (By similarity). May serve as a key control point at which color variation is determined. Major determinant of eye color (Probable). Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis (PubMed:12058062). Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; Melanosome membrane ; Multi-pass membrane protein Most abundant in melanocytes. Also present in neonatal and adult eye tissue presumably as a result of expression in the retinal pigmented epithelium and choroid body, known sites of melanogenesis in the eye. Small but detectable amounts also observed in fetal, neonatal and adult brain. Moderate amounts detected in adult testis and ovary. Not detected in heart, kidney, spleen, liver or thymus. Note=Defects in Oca2 are a cause of hypopigmentation of the eyes, skin, and fur. The protein is missing or altered in six independent mutant alleles of the OCA2 locus, suggesting that disruption of this gene results in hypopigmentation phenotype that defines mutant OCA2 alleles. Belongs to the CitM (TC 2.A.11) transporter family. Name=Protein Spotlight; Note=Questioning colour - Issue 54 of January 2005; URL="https://web.expasy.org/spotlight/back_issues/054"; lysosomal membrane endoplasmic reticulum membrane spermatid development cell proliferation endosome membrane membrane integral component of membrane melanocyte differentiation melanosome membrane melanin biosynthetic process pigmentation developmental pigmentation transmembrane transport uc009hdy.1 uc009hdy.2 uc009hdy.3 
ENSMUST00000032635.14 Nipa2 ENSMUST00000032635.14 non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human), transcript variant 4 (from RefSeq NM_001256132.1) ENSMUST00000032635.1 ENSMUST00000032635.10 ENSMUST00000032635.11 ENSMUST00000032635.12 ENSMUST00000032635.13 ENSMUST00000032635.2 ENSMUST00000032635.3 ENSMUST00000032635.4 ENSMUST00000032635.5 ENSMUST00000032635.6 ENSMUST00000032635.7 ENSMUST00000032635.8 ENSMUST00000032635.9 MNCb-2146 NIPA2_MOUSE NM_001256132 Q3U3I0 Q9JJC8 uc009hdq.1 uc009hdq.2 uc009hdq.3 uc009hdq.4 Acts as a selective Mg(2+) transporter. Reaction=Mg(2+)(in) = Mg(2+)(out); Xref=Rhea:RHEA:29827, ChEBI:CHEBI:18420; Evidence=; Kinetic parameters: KM=0.31 mM for magnesium ions ; Cell membrane ; Multi-pass membrane protein Early endosome Note=Recruited to the cell membrane in response to low extracellular magnesium. Widely expressed. Expressed at high levels in the kidney. Up-regulated by low magnesium ion levels. Belongs to the NIPA family. protein binding endosome early endosome plasma membrane ion transport magnesium ion transmembrane transporter activity magnesium ion transport membrane integral component of membrane magnesium ion transmembrane transport uc009hdq.1 uc009hdq.2 uc009hdq.3 uc009hdq.4 
ENSMUST00000032648.5 4933421I07Rik ENSMUST00000032648.5 RIKEN cDNA 4933421I07 gene, transcript variant 2 (from RefSeq NM_027702.3) 4933421I07Rik ENSMUST00000032648.1 ENSMUST00000032648.2 ENSMUST00000032648.3 ENSMUST00000032648.4 NM_027702 Q9D420 Q9D420_MOUSE uc009gma.1 uc009gma.2 uc009gma.3 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc009gma.1 uc009gma.2 uc009gma.3 
ENSMUST00000032658.14 Csrp3 ENSMUST00000032658.14 cysteine and glycine-rich protein 3, transcript variant 2 (from RefSeq NM_001198841.1) Csrp3 ENSMUST00000032658.1 ENSMUST00000032658.10 ENSMUST00000032658.11 ENSMUST00000032658.12 ENSMUST00000032658.13 ENSMUST00000032658.2 ENSMUST00000032658.3 ENSMUST00000032658.4 ENSMUST00000032658.5 ENSMUST00000032658.6 ENSMUST00000032658.7 ENSMUST00000032658.8 ENSMUST00000032658.9 NM_001198841 Q545C7 Q545C7_MOUSE uc009hay.1 uc009hay.2 uc009hay.3 uc009hay.4 cardiac muscle hypertrophy structural constituent of muscle Z disc telethonin binding protein localization to organelle detection of muscle stretch identical protein binding positive regulation of transcription from RNA polymerase II promoter metal ion binding cardiac muscle contraction uc009hay.1 uc009hay.2 uc009hay.3 uc009hay.4 
ENSMUST00000032661.14 Zfp819 ENSMUST00000032661.14 zinc finger protein 819, transcript variant 1 (from RefSeq NM_028913.3) ENSMUST00000032661.1 ENSMUST00000032661.10 ENSMUST00000032661.11 ENSMUST00000032661.12 ENSMUST00000032661.13 ENSMUST00000032661.2 ENSMUST00000032661.3 ENSMUST00000032661.4 ENSMUST00000032661.5 ENSMUST00000032661.6 ENSMUST00000032661.7 ENSMUST00000032661.8 ENSMUST00000032661.9 NM_028913 Q80V81 Q80V81_MOUSE Zfp819 uc009gne.1 uc009gne.2 uc009gne.3 uc009gne.4 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated positive regulation of apoptotic process sequence-specific DNA binding negative regulation of transcription, DNA-templated metal ion binding uc009gne.1 uc009gne.2 uc009gne.3 uc009gne.4 
ENSMUST00000032663.10 Ceacam18 ENSMUST00000032663.10 CEA cell adhesion molecule 18, transcript variant 1 (from RefSeq NM_028236.2) CEA18_MOUSE ENSMUST00000032663.1 ENSMUST00000032663.2 ENSMUST00000032663.3 ENSMUST00000032663.4 ENSMUST00000032663.5 ENSMUST00000032663.6 ENSMUST00000032663.7 ENSMUST00000032663.8 ENSMUST00000032663.9 NM_028236 Q9D871 uc009gnf.1 uc009gnf.2 uc009gnf.3 uc009gnf.4 Membrane ; Single-pass type I membrane protein Mostly expressed in the small and large intestine and at lower levels also in other organs. Belongs to the immunoglobulin superfamily. CEA family. molecular_function cellular_component biological_process membrane integral component of membrane uc009gnf.1 uc009gnf.2 uc009gnf.3 uc009gnf.4 
ENSMUST00000032667.10 Siglece ENSMUST00000032667.10 sialic acid binding Ig-like lectin E (from RefSeq NM_031181.2) E9QMD1 ENSMUST00000032667.1 ENSMUST00000032667.2 ENSMUST00000032667.3 ENSMUST00000032667.4 ENSMUST00000032667.5 ENSMUST00000032667.6 ENSMUST00000032667.7 ENSMUST00000032667.8 ENSMUST00000032667.9 NM_031181 Q91Y57 SIG12_MOUSE Siglec12 Siglec5 Siglecl1 uc009gng.1 uc009gng.2 Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Homodimer; disulfide-linked. Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. Q91Y57; Q9QUK6: Tlr4; NbExp=3; IntAct=EBI-16826475, EBI-1534575; Membrane; Single-pass type I membrane protein. Expressed by monocytic/myeloid lineage cells. Found at higher levels in spleen, liver and heart. Found at lower levels in kidney and lung. Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Phosphorylation of Tyr-432 is required for binding to PTPN6 and PTPN11. Phosphorylation of Tyr-455 is involved in binding to PTPN6. Tyr-432 needs to be phosphorylated prior to Tyr-455. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Name=Functional Glycomics Gateway - Glycan Binding; Note=Siglec-E; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Itlect_197"; protein binding cell adhesion external side of plasma membrane membrane integral component of membrane carbohydrate binding sialic acid binding monosaccharide binding negative regulation of inflammatory response negative regulation of phagocytosis, engulfment uc009gng.1 uc009gng.2 
ENSMUST00000032673.15 Zfp94 ENSMUST00000032673.15 zinc finger protein 94, transcript variant 2 (from RefSeq NM_009568.3) ENSMUST00000032673.1 ENSMUST00000032673.10 ENSMUST00000032673.11 ENSMUST00000032673.12 ENSMUST00000032673.13 ENSMUST00000032673.14 ENSMUST00000032673.2 ENSMUST00000032673.3 ENSMUST00000032673.4 ENSMUST00000032673.5 ENSMUST00000032673.6 ENSMUST00000032673.7 ENSMUST00000032673.8 ENSMUST00000032673.9 NM_009568 Q61117 Q61117_MOUSE Zfp94 uc009fpg.1 uc009fpg.2 uc009fpg.3 uc009fpg.4 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009fpg.1 uc009fpg.2 uc009fpg.3 uc009fpg.4 
ENSMUST00000032683.6 Lypd5 ENSMUST00000032683.6 Ly6/Plaur domain containing 5 (from RefSeq NM_029806.2) ENSMUST00000032683.1 ENSMUST00000032683.2 ENSMUST00000032683.3 ENSMUST00000032683.4 ENSMUST00000032683.5 LYPD5_MOUSE NM_029806 Q0VDW0 Q9D7Z7 uc009fpj.1 uc009fpj.2 uc009fpj.3 Cell membrane ; Lipid-anchor, GPI- anchor plasma membrane cell-matrix adhesion membrane anchored component of membrane laminin binding uc009fpj.1 uc009fpj.2 uc009fpj.3 
ENSMUST00000032704.12 Faap24 ENSMUST00000032704.12 Fanconi anemia core complex associated protein 24 (from RefSeq NM_178643.5) ENSMUST00000032704.1 ENSMUST00000032704.10 ENSMUST00000032704.11 ENSMUST00000032704.2 ENSMUST00000032704.3 ENSMUST00000032704.4 ENSMUST00000032704.5 ENSMUST00000032704.6 ENSMUST00000032704.7 ENSMUST00000032704.8 ENSMUST00000032704.9 FAP24_MOUSE Faap24 NM_178643 Q3TLJ2 Q8BHL6 uc009gjt.1 uc009gjt.2 uc009gjt.3 Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA (By similarity). Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM and FAAP24. Interacts with FANCM (By similarity). Nucleus The C-terminal region is distantly related to RuvA domain 2, a DNA-binding domain. DNA binding chromatin binding nucleus nucleoplasm DNA repair cellular response to DNA damage stimulus biological_process interstrand cross-link repair intracellular membrane-bounded organelle Fanconi anaemia nuclear complex uc009gjt.1 uc009gjt.2 uc009gjt.3 
ENSMUST00000032705.13 Rhpn2 ENSMUST00000032705.13 rhophilin, Rho GTPase binding protein 2 (from RefSeq NM_027897.4) ENSMUST00000032705.1 ENSMUST00000032705.10 ENSMUST00000032705.11 ENSMUST00000032705.12 ENSMUST00000032705.2 ENSMUST00000032705.3 ENSMUST00000032705.4 ENSMUST00000032705.5 ENSMUST00000032705.6 ENSMUST00000032705.7 ENSMUST00000032705.8 ENSMUST00000032705.9 NM_027897 Q8BWR8 Q9DBN2 RHPN2_MOUSE uc009gjs.1 uc009gjs.2 uc009gjs.3 uc009gjs.4 Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity). Interacts with GTP-bound RhoA and RhoB. Interacts with both GTP- and GDP-bound RhoA. Interacts with KRT18 (By similarity). Cytoplasm, perinuclear region Belongs to the RHPN family. molecular_function cytoplasm signal transduction biological_process perinuclear region of cytoplasm uc009gjs.1 uc009gjs.2 uc009gjs.3 uc009gjs.4 
ENSMUST00000032709.3 Kctd15 ENSMUST00000032709.3 potassium channel tetramerisation domain containing 15, transcript variant 3 (from RefSeq NM_001420858.1) ENSMUST00000032709.1 ENSMUST00000032709.2 KCD15_MOUSE NM_001420858 Q8K0E1 uc009gjg.1 uc009gjg.2 uc009gjg.3 uc009gjg.4 uc009gjg.5 During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity). Interacts with TFAP2A; this interaction inhibits TFAP2A transcriptional activation. Nucleus Note=In the brain, localizes to the arcuate hypothalamic nucleus, the ventromedial hypothalamic nucleus and the accumbens nucleus of the ventral striatum. Localizes to neurons in areas of the cerebral cortex, cerebellum and hypothalamus (at protein level). cellular_component multicellular organism development biological_process identical protein binding protein homooligomerization uc009gjg.1 uc009gjg.2 uc009gjg.3 uc009gjg.4 uc009gjg.5 
ENSMUST00000032710.7 Slc17a6 ENSMUST00000032710.7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6, transcript variant 1 (from RefSeq NM_080853.3) A0A0R4J0A6 A0A0R4J0A6_MOUSE ENSMUST00000032710.1 ENSMUST00000032710.2 ENSMUST00000032710.3 ENSMUST00000032710.4 ENSMUST00000032710.5 ENSMUST00000032710.6 NM_080853 Slc17a6 uc009hcf.1 uc009hcf.2 uc009hcf.3 uc009hcf.4 Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in); Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; Evidence=; Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out); Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103; Evidence=; Reaction=L-glutamate(out) = L-glutamate(in); Xref=Rhea:RHEA:66336, ChEBI:CHEBI:29985; Evidence=; Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; Reaction=phosphate(in) = phosphate(out); Xref=Rhea:RHEA:32823, ChEBI:CHEBI:43474; Evidence=; Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Synapse, synaptosome Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. integral component of plasma membrane membrane integral component of membrane transmembrane transport neurotransmitter loading into synaptic vesicle presynapse uc009hcf.1 uc009hcf.2 uc009hcf.3 uc009hcf.4 
ENSMUST00000032715.13 Prmt3 ENSMUST00000032715.13 protein arginine N-methyltransferase 3 (from RefSeq NM_133740.2) ANM3_MOUSE ENSMUST00000032715.1 ENSMUST00000032715.10 ENSMUST00000032715.11 ENSMUST00000032715.12 ENSMUST00000032715.2 ENSMUST00000032715.3 ENSMUST00000032715.4 ENSMUST00000032715.5 ENSMUST00000032715.6 ENSMUST00000032715.7 ENSMUST00000032715.8 ENSMUST00000032715.9 Hrmt1l3 NM_133740 Prmt3 Q3U2K1 Q80VU9 Q8BFV5 Q922H1 uc009hbt.1 uc009hbt.2 uc009hbt.3 Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (By similarity). May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (By similarity). Reaction=L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48100, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:11990, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65280; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48101; Evidence=; Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA- COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48097; Evidence=; Inhibited by N-ethylmaleimide and high concentrations of zinc chloride. Monomer and homodimer (By similarity). Interacts with EPB41L3 (via FERM domain); the interaction is direct and inhibits the protein- arginine N-methyltransferase activity of PRMT3. Interacts with the 40S ribosomal protein RPS2. Interacts with ALDH1A1; the interaction is direct, inhibits ALDH1A1 aldehyde dehydrogenase activity and is independent of the methyltransferase activity of PRMT3 (By similarity). Cytoplasm The C2H2-type zinc-finger is responsible for substrate specificity. Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. protein binding nucleus cytoplasm cytosol protein methylation methyltransferase activity protein-arginine N-methyltransferase activity transferase activity peptidyl-arginine methylation peptidyl-arginine methylation, to asymmetrical-dimethyl arginine negative regulation of protein ubiquitination methylation protein-arginine omega-N asymmetric methyltransferase activity ribosome binding metal ion binding dendritic spine morphogenesis modified amino acid binding uc009hbt.1 uc009hbt.2 uc009hbt.3 
ENSMUST00000032717.7 Dbx1 ENSMUST00000032717.7 developing brain homeobox 1 (from RefSeq NM_001005232.1) DBX1_MOUSE Dbx ENSMUST00000032717.1 ENSMUST00000032717.2 ENSMUST00000032717.3 ENSMUST00000032717.4 ENSMUST00000032717.5 ENSMUST00000032717.6 NM_001005232 P52950 Q3UYQ7 uc009hbn.1 uc009hbn.2 uc009hbn.3 Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons. Nucleus. During early and mid-gestation, dbx expression is restricted to the telencephalon, diencephalon, dorsal mesencephalon and spinal cord. At later gestational stages, dbx expression continues in the dorsal mesencephalon and diencephalon, in which expression is more restricted than at the earlier stages. Belongs to the H2.0 homeobox family. DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development cell differentiation in spinal cord ventral spinal cord interneuron specification sequence-specific DNA binding uc009hbn.1 uc009hbn.2 uc009hbn.3 
ENSMUST00000032719.15 Nav3 ENSMUST00000032719.15 neuron navigator 3, transcript variant 2 (from RefSeq NM_001368815.1) E9QMF5 E9QMF5_MOUSE ENSMUST00000032719.1 ENSMUST00000032719.10 ENSMUST00000032719.11 ENSMUST00000032719.12 ENSMUST00000032719.13 ENSMUST00000032719.14 ENSMUST00000032719.2 ENSMUST00000032719.3 ENSMUST00000032719.4 ENSMUST00000032719.5 ENSMUST00000032719.6 ENSMUST00000032719.7 ENSMUST00000032719.8 ENSMUST00000032719.9 NM_001368815 Nav3 uc007gzl.1 uc007gzl.2 uc007gzl.3 Belongs to the Nav/unc-53 family. ATP binding negative regulation of microtubule depolymerization microtubule binding neurogenesis negative regulation of cell migration positive regulation of microtubule polymerization negative regulation of interleukin-2 production microtubule end uc007gzl.1 uc007gzl.2 uc007gzl.3 
ENSMUST00000032728.9 Tars3 ENSMUST00000032728.9 threonyl-tRNA synthetase 3 (from RefSeq NM_172310.2) ENSMUST00000032728.1 ENSMUST00000032728.2 ENSMUST00000032728.3 ENSMUST00000032728.4 ENSMUST00000032728.5 ENSMUST00000032728.6 ENSMUST00000032728.7 ENSMUST00000032728.8 NM_172310 Q8BLY2 Q8CHT2 SYTC2_MOUSE Tarsl2 uc009hgs.1 uc009hgs.2 uc009hgs.3 uc009hgs.4 Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post- transfer stage. Reaction=ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L- threonyl-tRNA(Thr); Xref=Rhea:RHEA:24624, Rhea:RHEA-COMP:9670, Rhea:RHEA-COMP:9704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57926, ChEBI:CHEBI:78442, ChEBI:CHEBI:78534, ChEBI:CHEBI:456215; EC=6.1.1.3; Evidence=; May be a component of the multisynthetase complex (MSC), a large multi-subunit complex which contains at least eight different aminoacyl-tRNA synthetases plus three auxillary subunits AIMP1, AIMP2 and EEF1E1. Interacts with the MSC components EPRS1, AIMP1, AIMP2 and KARS1. Cytoplasm Nucleus Note=Primarily cytoplasmic. Also detected at lower levels in the nucleus. Ubiquitous (at protein level). Strongly expressed in muscle (at protein level). Moderately expressed in heart and liver (at protein level). Weakly expressed in stomach, kidney, testis, spleen, brain, fat and lung (at protein level). Belongs to the class-II aminoacyl-tRNA synthetase family. nucleotide binding aminoacyl-tRNA ligase activity threonine-tRNA ligase activity ATP binding nucleus cytoplasm translation tRNA aminoacylation for protein translation threonyl-tRNA aminoacylation ligase activity tRNA aminoacylation uc009hgs.1 uc009hgs.2 uc009hgs.3 uc009hgs.4 
ENSMUST00000032729.8 Tjp1 ENSMUST00000032729.8 tight junction protein 1, transcript variant 5 (from RefSeq NM_001417368.1) B9EHJ3 B9EHJ3_MOUSE ENSMUST00000032729.1 ENSMUST00000032729.2 ENSMUST00000032729.3 ENSMUST00000032729.4 ENSMUST00000032729.5 ENSMUST00000032729.6 ENSMUST00000032729.7 NM_001417368 Tjp1 uc009hgo.1 uc009hgo.2 uc009hgo.3 uc009hgo.4 Cell junction, tight junction Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane ; Peripheral membrane protein ; Cytoplasmic side bicellular tight junction uc009hgo.1 uc009hgo.2 uc009hgo.3 uc009hgo.4 
ENSMUST00000032732.15 Apba2 ENSMUST00000032732.15 amyloid beta precursor protein binding family A member 2, transcript variant 3 (from RefSeq NM_007461.3) APBA2_MOUSE ENSMUST00000032732.1 ENSMUST00000032732.10 ENSMUST00000032732.11 ENSMUST00000032732.12 ENSMUST00000032732.13 ENSMUST00000032732.14 ENSMUST00000032732.2 ENSMUST00000032732.3 ENSMUST00000032732.4 ENSMUST00000032732.5 ENSMUST00000032732.6 ENSMUST00000032732.7 ENSMUST00000032732.8 ENSMUST00000032732.9 NM_007461 P98084 Q6PAJ2 X11l uc009hgj.1 uc009hgj.2 uc009hgj.3 uc009hgj.4 Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid-beta protein, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N- terminal domain of NECAB3 (By similarity). P98084; P12023: App; NbExp=2; IntAct=EBI-81669, EBI-78814; P98084; P49768: PSEN1; Xeno; NbExp=2; IntAct=EBI-81669, EBI-297277; Specifically expressed in neurons, predominantly of the cerebellum, hippocampus, and spinal cord. Lesser extent in neurons of the cerebral cortex and anterior thalmic nuclei. Composed of an N-terminal domain that binds STXBP1, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C- terminal PDZ domains thought to attach proteins to the plasma membrane. Was originally thought to be the ortholog of human X11 (APBA1). beta-amyloid binding in utero embryonic development protein binding cytoplasm plasma membrane chemical synaptic transmission locomotory behavior synaptic vesicle regulation of gene expression protein transport multicellular organism growth identical protein binding dendritic spine synapse regulation of synaptic vesicle exocytosis uc009hgj.1 uc009hgj.2 uc009hgj.3 uc009hgj.4 
ENSMUST00000032735.8 Mphosph10 ENSMUST00000032735.8 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) (from RefSeq NM_026483.2) E9QM78 ENSMUST00000032735.1 ENSMUST00000032735.2 ENSMUST00000032735.3 ENSMUST00000032735.4 ENSMUST00000032735.5 ENSMUST00000032735.6 ENSMUST00000032735.7 MPP10_MOUSE NM_026483 Q810V0 uc009hgg.1 uc009hgg.2 uc009hgg.3 Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with IMP3 and IMP4. Nucleus, nucleolus Chromosome Note=Fibrillar region of the nucleolus. After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase. In telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin. The reassociation with nucleolus is preceeded by the arrival of fibrillarin. Phosphorylated in M (mitotic) phase. Belongs to the MPP10 family. nucleus chromosome nucleolus small nucleolar ribonucleoprotein complex rRNA processing negative regulation of phosphatase activity small-subunit processome Mpp10 complex ribosome biogenesis uc009hgg.1 uc009hgg.2 uc009hgg.3 
ENSMUST00000032736.11 Mtmr10 ENSMUST00000032736.11 myotubularin related protein 10, transcript variant 1 (from RefSeq NM_172742.3) ENSMUST00000032736.1 ENSMUST00000032736.10 ENSMUST00000032736.2 ENSMUST00000032736.3 ENSMUST00000032736.4 ENSMUST00000032736.5 ENSMUST00000032736.6 ENSMUST00000032736.7 ENSMUST00000032736.8 ENSMUST00000032736.9 MTMRA_MOUSE NM_172742 Q6PE99 Q7TPM9 uc009hgd.1 uc009hgd.2 Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 399 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity. Sequence=AAH55074.1; Type=Miscellaneous discrepancy; Note=Sequence of unknown origin in the N-terminal part.; Evidence=; cytoplasm uc009hgd.1 uc009hgd.2 
ENSMUST00000032738.7 Chrna7 ENSMUST00000032738.7 cholinergic receptor, nicotinic, alpha polypeptide 7 (from RefSeq NM_007390.3) Chrna7 ENSMUST00000032738.1 ENSMUST00000032738.2 ENSMUST00000032738.3 ENSMUST00000032738.4 ENSMUST00000032738.5 ENSMUST00000032738.6 NM_007390 Q53YJ9 Q53YJ9_MOUSE uc009vel.1 uc009vel.2 uc009vel.3 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub- subfamily. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane ion transport membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction ion transmembrane transport synapse postsynaptic membrane regulation of postsynaptic membrane potential excitatory postsynaptic potential uc009vel.1 uc009vel.2 uc009vel.3 
ENSMUST00000032747.7 Hddc3 ENSMUST00000032747.7 HD domain containing 3, transcript variant 13 (from RefSeq NR_184855.1) ENSMUST00000032747.1 ENSMUST00000032747.2 ENSMUST00000032747.3 ENSMUST00000032747.4 ENSMUST00000032747.5 ENSMUST00000032747.6 MESH1_MOUSE Mesh1 NR_184855 Q9D114 uc009ian.1 uc009ian.2 uc009ian.3 ppGpp hydrolyzing enzyme involved in starvation response. Reaction=guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H(+); Xref=Rhea:RHEA:14253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:58189, ChEBI:CHEBI:77828; EC=3.1.7.2; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Belongs to the MESH1 family. cellular_component guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity hydrolase activity metal ion binding uc009ian.1 uc009ian.2 uc009ian.3 
ENSMUST00000032748.15 Unc45a ENSMUST00000032748.15 unc-45 myosin chaperone A (from RefSeq NM_133952.2) ENSMUST00000032748.1 ENSMUST00000032748.10 ENSMUST00000032748.11 ENSMUST00000032748.12 ENSMUST00000032748.13 ENSMUST00000032748.14 ENSMUST00000032748.2 ENSMUST00000032748.3 ENSMUST00000032748.4 ENSMUST00000032748.5 ENSMUST00000032748.6 ENSMUST00000032748.7 ENSMUST00000032748.8 ENSMUST00000032748.9 NM_133952 Q3TKV6 Q8BFT3 Q8C157 Q99KD5 Smap1 UN45A_MOUSE uc291ruq.1 uc291ruq.2 May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen. Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer (By similarity). Cytoplasm Cytoplasm, perinuclear region Nucleus Note=Predominant in the perinuclear region. Little protein in the nucleus (By similarity). Detected in spleen, bone marrow, lung and ovary, and at lower levels in testis, kidney, heart and brain (at protein level). Ubiquitous. Detected in uterus, large intestine, kidney, spleen, lung, brain, liver and ovary. protein binding nucleus cytoplasm Golgi apparatus cytosol multicellular organism development muscle organ development nuclear speck cell differentiation perinuclear region of cytoplasm Hsp90 protein binding chaperone-mediated protein folding uc291ruq.1 uc291ruq.2 
ENSMUST00000032749.12 Vps33b ENSMUST00000032749.12 vacuolar protein sorting 33B, transcript variant 1 (from RefSeq NM_178070.5) ENSMUST00000032749.1 ENSMUST00000032749.10 ENSMUST00000032749.11 ENSMUST00000032749.2 ENSMUST00000032749.3 ENSMUST00000032749.4 ENSMUST00000032749.5 ENSMUST00000032749.6 ENSMUST00000032749.7 ENSMUST00000032749.8 ENSMUST00000032749.9 NM_178070 P59016 VP33B_MOUSE uc012fnm.1 uc012fnm.2 uc012fnm.3 May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Required for proper trafficking and targeting of the collagen-modifying enzyme lysyl hydroxylase 3 (LH3) to intracellular collagen (By similarity). Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating in part VIPAS39 (By similarity). In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A- dependentrecycling pathway and in the maintenance of the apical- basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha- granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (PubMed:25947942). Interacts with RAB11A and VIPAS39 (PubMed:20190753). Associates with adapter protein complex 3 (AP-3), clathrin:AP-3 and clathrin:HGS complexes (PubMed:21411634). P59016; P62492: Rab11a; NbExp=3; IntAct=EBI-2656383, EBI-770256; Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Early endosome Cytoplasmic vesicle, clathrin-coated vesicle Recycling endosome Note=Colocalizes in clusters with VIPAS39 at cytoplasmic organelles. Colocalizes with RAB11A and VIPAS39 on recycling endosomes. Colocalizes with AP-3, clathrin, Rab5 and Rab7b. Phosphorylated on tyrosine residues. Increased platelet account and deficiency in platelet alpha-granules associated with bleeding diathesis and decreases aggregate formation; reduction of mature ype-II multivesicular bodies (MVB II) in megakaryocytes. Vps33b-deficient inner medullary collecting duct cells display abnormal expression of membrane proteins such as Ceacam5, structural and functional tight junction defects and reduced E-cadherin expression. Belongs to the STXBP/unc-18/SEC1 family. protein binding cytoplasm lysosome lysosomal membrane endosome early endosome late endosome Golgi apparatus intracellular protein transport vesicle docking involved in exocytosis endosome organization synaptic vesicle protein transport membrane vesicle-mediated transport peptidyl-lysine hydroxylation clathrin-coated vesicle collagen fibril organization platelet alpha granule cytoplasmic vesicle early endosome membrane late endosome membrane melanosome localization lysosome localization collagen metabolic process megakaryocyte development macromolecular complex binding perinuclear region of cytoplasm recycling endosome membrane fusion platelet alpha granule organization regulation of platelet aggregation uc012fnm.1 uc012fnm.2 uc012fnm.3 
ENSMUST00000032754.9 Sema4b ENSMUST00000032754.9 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B, transcript variant 1 (from RefSeq NM_013659.5) ENSMUST00000032754.1 ENSMUST00000032754.2 ENSMUST00000032754.3 ENSMUST00000032754.4 ENSMUST00000032754.5 ENSMUST00000032754.6 ENSMUST00000032754.7 ENSMUST00000032754.8 Kiaa1745 NM_013659 Q4PKI6 Q62179 Q69ZB7 SEM4B_MOUSE SemC Sema4b Semac uc009hzp.1 uc009hzp.2 uc009hzp.3 Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. Interacts with GIPC PDZ domain. Membrane; Single-pass type I membrane protein. Expressed from day 10 in the embryo. Low levels found between days 10-12. Expression peaks on day 13 with moderate levels from then until birth. Belongs to the semaphorin family. Sequence=BAD32527.1; Type=Erroneous initiation; Evidence=; neural crest cell migration protein binding extracellular space plasma membrane integral component of plasma membrane multicellular organism development nervous system development membrane integral component of membrane cell differentiation semaphorin receptor binding positive regulation of cell migration synapse chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway uc009hzp.1 uc009hzp.2 uc009hzp.3 
ENSMUST00000032760.6 Mesp1 ENSMUST00000032760.6 mesoderm posterior 1 (from RefSeq NM_008588.2) ENSMUST00000032760.1 ENSMUST00000032760.2 ENSMUST00000032760.3 ENSMUST00000032760.4 ENSMUST00000032760.5 MESP1_MOUSE NM_008588 P97309 Q059W2 uc009hzb.1 uc009hzb.2 uc009hzb.3 uc009hzb.4 Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways. Nucleus No expression was detected in adult tissues except the testis. Expression in the testis was regulated developmentally; expressed 2 weeks after birth, and increases, reaching the full expression level in mature testes. The earliest expression is detected at the junction of the epiblast and extraembryonic ectoderm, which is the initiation site for gastrulation. Around 6.5-6.75 dpc, expression becomes evident as gastrulation progresses. Expression does not spread over all mesodermal cells; it is seen only in a fraction of cells, particularly those in the early emergence group destined to become the extraembryonic mesoderm and the most posterior part of the tailbud. Expression remains for a while at the base of the allantois, and then spreads out to the lateral margins of the tail bud mesoderm. Expressed in the anterior presomitic mesoderm in a broad or thin stripe pattern. Expressed in the paraxial mesoderm during somitogenesis. Expression disappears before 8.5 dpc. Expression is induced by Notch signaling. Mice embryos exhibit defects in single heart tube formation, due to a delay in mesodermal migration. However, the cells eventually acquired migratory activity and gave rise to an abnormal heart tube. Mice lacking Mesp1 and Mesp2 die around 9.5 dpc. The major defect is the apparent lack of any mesodermal layer between endoderm and ectoderm and a defect in the migratory activity of mesodermal cells. It seems that a compensatory mechanism exists in which Mesp1 expression is up-regulated in the absence of Mesp2. Mesp1 may be involved in the rescue of somitogenesis in the null Mesp2 embryos. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding mesoderm formation somitogenesis heart looping heart morphogenesis secondary heart field specification embryonic heart tube morphogenesis cardiac atrium formation cardiac ventricle formation sinus venosus morphogenesis growth involved in heart morphogenesis cardioblast anterior-lateral migration cardioblast migration DNA binding transcription factor activity, sequence-specific DNA binding nucleus Notch signaling pathway multicellular organism development gastrulation mesodermal cell migration neurogenesis signal transduction involved in regulation of gene expression enhancer binding positive regulation of Notch signaling pathway involved in heart induction negative regulation of mesodermal cell fate specification negative regulation of endodermal cell fate specification transcription regulatory region DNA binding endothelial cell differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity lateral mesoderm development positive regulation of striated muscle cell differentiation cardiac muscle cell differentiation cardiac cell fate determination sinoatrial node cell differentiation cardiac vascular smooth muscle cell differentiation cardioblast migration to the midline involved in heart field formation positive regulation of hepatocyte differentiation positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway uc009hzb.1 uc009hzb.2 uc009hzb.3 uc009hzb.4 
ENSMUST00000032761.8 Pex11a ENSMUST00000032761.8 peroxisomal biogenesis factor 11 alpha, transcript variant 1 (from RefSeq NM_011068.2) ENSMUST00000032761.1 ENSMUST00000032761.2 ENSMUST00000032761.3 ENSMUST00000032761.4 ENSMUST00000032761.5 ENSMUST00000032761.6 ENSMUST00000032761.7 NM_011068 PX11A_MOUSE Q8C5B8 Q9Z211 uc009hyy.1 uc009hyy.2 uc009hyy.3 May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxisomal surface. Homodimer. Heterodimer with PEX11G. Probably interacts with COPB2 and COPA. Interacts with PEX19. Interacts with FIS1. Peroxisome membrane ; Multi-pass membrane protein Strongly expressed in liver and at lower levels in heart, brain, kidney and testis. By ciprofibrate. Mice have no detectable defect in constitutive peroxisome division and display a normal peroxisome proliferation response when exposed to PPARalpha-activating drugs. However, they are defective in peroxisome proliferation induced by 4-phenylbutyrate (4- PBA). Belongs to the peroxin-11 family. peroxisome peroxisomal membrane integral component of peroxisomal membrane peroxisome organization signal transduction membrane integral component of membrane peroxisome membrane biogenesis peroxisome fission macromolecular complex protein homodimerization activity regulation of peroxisome size brown fat cell differentiation uc009hyy.1 uc009hyy.2 uc009hyy.3 
ENSMUST00000032766.5 Rhcg ENSMUST00000032766.5 Rhesus blood group-associated C glycoprotein (from RefSeq NM_019799.3) ENSMUST00000032766.1 ENSMUST00000032766.2 ENSMUST00000032766.3 ENSMUST00000032766.4 NM_019799 Q8BVS0 Q9QXP0 RHCG_MOUSE uc009hyo.1 uc009hyo.2 uc009hyo.3 Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (PubMed:16131648) (By similarity). May act as a CO2 channel providing for renal acid secretion (By similarity). Reaction=NH4(+)(in) = NH4(+)(out); Xref=Rhea:RHEA:28747, ChEBI:CHEBI:28938; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28748; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28749; Evidence=; Reaction=methylamine(out) = methylamine(in); Xref=Rhea:RHEA:74391, ChEBI:CHEBI:59338; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74392; Evidence=; Reaction=CO2(out) = CO2(in); Xref=Rhea:RHEA:74891, ChEBI:CHEBI:16526; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74892; Evidence=; Kinetic parameters: KM=10 mM for methylamine ; Homotrimer. Apical cell membrane ; Multi-pass membrane protein te=Also detected at the basolateral membrane and in subapical vesicles. Expressed in the forestomach and the fundus of the stomach. Expressed at the level of villous in duodenum, jejunum, ileum and colon. Expressed in kidney by connecting segments and collecting tubules (at protein level). Expressed in testis by seminiferous tubules. N-glycosylated. Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. plasma membrane integral component of plasma membrane cellular ion homeostasis regulation of pH ammonium transmembrane transporter activity basal plasma membrane ammonium transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane ankyrin binding cytoplasmic vesicle identical protein binding transepithelial ammonium transport ammonium transmembrane transport uc009hyo.1 uc009hyo.2 uc009hyo.3 
ENSMUST00000032768.15 Nr2f2 ENSMUST00000032768.15 nuclear receptor subfamily 2, group F, member 2, transcript variant 1 (from RefSeq NM_009697.3) ENSMUST00000032768.1 ENSMUST00000032768.10 ENSMUST00000032768.11 ENSMUST00000032768.12 ENSMUST00000032768.13 ENSMUST00000032768.14 ENSMUST00000032768.2 ENSMUST00000032768.3 ENSMUST00000032768.4 ENSMUST00000032768.5 ENSMUST00000032768.6 ENSMUST00000032768.7 ENSMUST00000032768.8 ENSMUST00000032768.9 NM_009697 Nr2f2 Q3UST6 Q3UST6_MOUSE uc009hni.1 uc009hni.2 uc009hni.3 Nucleus Belongs to the nuclear hormone receptor family. NR2 subfamily. negative regulation of transcription from RNA polymerase II promoter negative regulation of endothelial cell proliferation retinoic acid binding positive regulation of systemic arterial blood pressure DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated zinc ion binding negative regulation of endothelial cell migration intracellular receptor signaling pathway response to estradiol protein homodimerization activity steroid hormone mediated signaling pathway sequence-specific DNA binding negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated metal ion binding regulation of transcription involved in lymphatic endothelial cell fate commitment uc009hni.1 uc009hni.2 uc009hni.3 
ENSMUST00000032779.12 Ctsc ENSMUST00000032779.12 cathepsin C, transcript variant 5 (from RefSeq NR_178180.1) Ctsc ENSMUST00000032779.1 ENSMUST00000032779.10 ENSMUST00000032779.11 ENSMUST00000032779.2 ENSMUST00000032779.3 ENSMUST00000032779.4 ENSMUST00000032779.5 ENSMUST00000032779.6 ENSMUST00000032779.7 ENSMUST00000032779.8 ENSMUST00000032779.9 NR_178180 Q3UBY5 Q3UBY5_MOUSE uc009ifu.1 uc009ifu.2 uc009ifu.3 uc009ifu.4 uc009ifu.5 Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.; EC=3.4.14.1; Evidence=; Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence=; Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. Lysosome Belongs to the peptidase C1 family. nucleoplasm lysosome endoplasmic reticulum Golgi apparatus centrosome proteolysis aging peptidase activity cysteine-type peptidase activity response to organic substance hydrolase activity phosphatase binding chloride ion binding identical protein binding intracellular membrane-bounded organelle protein self-association chaperone binding positive regulation of proteolysis involved in cellular protein catabolic process uc009ifu.1 uc009ifu.2 uc009ifu.3 uc009ifu.4 uc009ifu.5 
ENSMUST00000032781.14 Nox4 ENSMUST00000032781.14 NADPH oxidase 4, transcript variant 1 (from RefSeq NM_015760.5) ENSMUST00000032781.1 ENSMUST00000032781.10 ENSMUST00000032781.11 ENSMUST00000032781.12 ENSMUST00000032781.13 ENSMUST00000032781.2 ENSMUST00000032781.3 ENSMUST00000032781.4 ENSMUST00000032781.5 ENSMUST00000032781.6 ENSMUST00000032781.7 ENSMUST00000032781.8 ENSMUST00000032781.9 NM_015760 NOX4_MOUSE Q3TF39 Q8C3M1 Q8VCA3 Q9JHI8 Renox uc009ifl.1 uc009ifl.2 uc009ifl.3 uc009ifl.4 NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 (By similarity). Can also catalyze to a smaller extent, the reduction of oxygen to superoxide (PubMed:10869423, PubMed:11098048, PubMed:15638999). May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity (By similarity). May regulate insulin signaling cascade (By similarity). May play a role in apoptosis, bone resorption and lipolysaccharide- mediated activation of NFKB (By similarity). May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation (By similarity). Reaction=NADPH + 2 O2 = H(+) + NADP(+) + 2 superoxide; Xref=Rhea:RHEA:63180, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18421, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence= Reaction=H(+) + NADPH + O2 = H2O2 + NADP(+); Xref=Rhea:RHEA:11260, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.6.3.1; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Activated by insulin. Inhibited by diphenylene iodonium (By similarity). Inhibited by plumbagin. Activated by phorbol 12-myristate 13-acetate (PMA). Interacts with, relocalizes and stabilizes CYBA/p22phox. Interacts with TLR4. Interacts with protein disulfide isomerase (By similarity). Interacts with PPP1R15A (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Cell junction, focal adhesion Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9JHI8-1; Sequence=Displayed; Name=2; IsoId=Q9JHI8-2; Sequence=VSP_019060, VSP_019061; Name=3; IsoId=Q9JHI8-3; Sequence=VSP_019063, VSP_019064; Name=4; IsoId=Q9JHI8-4; Sequence=VSP_019062; EXpressed in brain, in all layers of the cerebellum, in pyramidal cells of the Ammon horn and in Purkinje cells (at protein level). Expressed in osteoclasts, leukocytes, kidney, liver and lung. Upon brain ischemia it is up-regulated in ischemic tissues and more specially in neocapillaries (at protein level). Up-regulated upon hypoxia. N-glycosylation is required for the function. Sequence=BC021378; Type=Frameshift; Evidence=; cell morphogenesis response to hypoxia stress fiber heart process nucleus mitochondrion endoplasmic reticulum endoplasmic reticulum membrane plasma membrane focal adhesion superoxide metabolic process defense response aging cell aging negative regulation of cell proliferation gene expression positive regulation of smooth muscle cell migration membrane integral component of membrane NAD(P)H oxidase activity superoxide-generating NADPH oxidase activity apical plasma membrane oxidoreductase activity cell junction superoxide anion generation NADPH oxidase complex positive regulation of apoptotic process positive regulation of MAP kinase activity bone resorption perinuclear region of cytoplasm oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor homocysteine metabolic process positive regulation of stress fiber assembly positive regulation of protein kinase B signaling cardiac muscle cell differentiation oxidation-reduction process positive regulation of protein tyrosine kinase activity positive regulation of ERK1 and ERK2 cascade cellular response to cAMP cellular response to glucose stimulus cellular response to gamma radiation cellular response to transforming growth factor beta stimulus cell periphery modified amino acid binding reactive oxygen species metabolic process perinuclear endoplasmic reticulum protein tyrosine kinase binding positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process uc009ifl.1 uc009ifl.2 uc009ifl.3 uc009ifl.4 
ENSMUST00000032800.10 Tyrobp ENSMUST00000032800.10 TYRO protein tyrosine kinase binding protein (from RefSeq NM_011662.3) ENSMUST00000032800.1 ENSMUST00000032800.2 ENSMUST00000032800.3 ENSMUST00000032800.4 ENSMUST00000032800.5 ENSMUST00000032800.6 ENSMUST00000032800.7 ENSMUST00000032800.8 ENSMUST00000032800.9 NM_011662 Q3U419 Q3U419_MOUSE Tyrobp uc291nvs.1 uc291nvs.2 Belongs to the TYROBP family. myeloid leukocyte activation receptor binding cell surface membrane integral component of membrane kinase activity phosphorylation osteoclast differentiation negative regulation of B cell proliferation positive regulation of macrophage fusion identical protein binding protein stabilization positive regulation of protein localization to cell surface uc291nvs.1 uc291nvs.2 
ENSMUST00000032802.5 Zfp84 ENSMUST00000032802.5 zinc finger protein 84 (from RefSeq NM_023750.2) ENSMUST00000032802.1 ENSMUST00000032802.2 ENSMUST00000032802.3 ENSMUST00000032802.4 NM_023750 Q9D654 Q9D654_MOUSE Zfp84 uc009gbz.1 uc009gbz.2 uc009gbz.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc009gbz.1 uc009gbz.2 uc009gbz.3 
ENSMUST00000032803.12 Zfp30 ENSMUST00000032803.12 zinc finger protein 30, transcript variant 3 (from RefSeq NM_013705.2) Bsg3 ENSMUST00000032803.1 ENSMUST00000032803.10 ENSMUST00000032803.11 ENSMUST00000032803.2 ENSMUST00000032803.3 ENSMUST00000032803.4 ENSMUST00000032803.5 ENSMUST00000032803.6 ENSMUST00000032803.7 ENSMUST00000032803.8 ENSMUST00000032803.9 NM_013705 Q78FW7 Q78FW7_MOUSE Zfp30 uc009gcb.1 uc009gcb.2 uc009gcb.3 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009gcb.1 uc009gcb.2 uc009gcb.3 
ENSMUST00000032808.6 2200002D01Rik ENSMUST00000032808.6 RIKEN cDNA 2200002D01 gene (from RefSeq NM_028179.1) 2200002D01Rik ENSMUST00000032808.1 ENSMUST00000032808.2 ENSMUST00000032808.3 ENSMUST00000032808.4 ENSMUST00000032808.5 NM_028179 Q9D809 Q9D809_MOUSE uc009gbj.1 uc009gbj.2 uc009gbj.3 uc009gbj.4 molecular_function nucleus nucleolus biological_process uc009gbj.1 uc009gbj.2 uc009gbj.3 uc009gbj.4 
ENSMUST00000032811.12 Rasgrp4 ENSMUST00000032811.12 RAS guanyl releasing protein 4, transcript variant 3 (from RefSeq NR_045676.1) ENSMUST00000032811.1 ENSMUST00000032811.10 ENSMUST00000032811.11 ENSMUST00000032811.2 ENSMUST00000032811.3 ENSMUST00000032811.4 ENSMUST00000032811.5 ENSMUST00000032811.6 ENSMUST00000032811.7 ENSMUST00000032811.8 ENSMUST00000032811.9 GRP4_MOUSE NR_045676 Q3TNQ1 Q3TRL5 Q3U3I4 Q811P7 Q8BKV7 Q8BTM9 Q91ZC8 Q920A2 uc057lto.1 uc057lto.2 Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation. Cytoplasm. Cell membrane. Note=Recruited to membranes upon activation by DAG. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=RASGRP4alpha; IsoId=Q8BTM9-1; Sequence=Displayed; Name=2; Synonyms=RASGRP4beta; IsoId=Q8BTM9-2; Sequence=VSP_030483; Name=3; IsoId=Q8BTM9-3; Sequence=VSP_030484, VSP_030487; Name=4; IsoId=Q8BTM9-4; Sequence=VSP_030485, VSP_030486; Expressed by mast cells and their progenitors (at protein level). Expressed at all stages in the development of mast cells. The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG. [Isoform 3]: Due to an intron retention. [Isoform 4]: Minor isoform which is not activated by DAG and probably not functional. Preferentially expressed in the C3H/HeJ strain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the RASGRP family. Sequence=BAE32802.1; Type=Frameshift; Evidence=; guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity cytoplasm plasma membrane small GTPase mediated signal transduction cell proliferation response to extracellular stimulus membrane cell differentiation intracellular signal transduction positive regulation of Ras protein signal transduction metal ion binding uc057lto.1 uc057lto.2 
ENSMUST00000032815.11 Nfkbib ENSMUST00000032815.11 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta, transcript variant 1 (from RefSeq NM_010908.5) ENSMUST00000032815.1 ENSMUST00000032815.10 ENSMUST00000032815.2 ENSMUST00000032815.3 ENSMUST00000032815.4 ENSMUST00000032815.5 ENSMUST00000032815.6 ENSMUST00000032815.7 ENSMUST00000032815.8 ENSMUST00000032815.9 IKBB_MOUSE Ikbb NM_010908 Q564F1 Q60778 Q9D6L5 uc009fzr.1 uc009fzr.2 uc009fzr.3 uc009fzr.4 This gene encodes an inhibitor of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB). The encoded protein prevents NF-kappaB-mediated transcription activation by sequestering it in the cytosol. In response to signals that induce NF-kappaB, such as cytokines and growth factors, the encoded protein undergoes phosphorylation, triggering its rapid ubiquitination and proteasomal degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. Interacts with THRB (via ligand-binding domain) (By similarity). Interacts with RELA and REL (PubMed:8816457). Interacts with COMMD1 (By similarity). Interacts with inhibitor kappa B- interacting Ras-like NKIRAS1 and NKIRAS2 (PubMed:10657303). Q60778; Q9Z1K6: Arih2; NbExp=2; IntAct=EBI-644469, EBI-6861719; Q60778; P15307: Rel; NbExp=5; IntAct=EBI-644469, EBI-5323778; Q60778; Q04207: Rela; NbExp=12; IntAct=EBI-644469, EBI-644400; Cytoplasm. Nucleus. Highly expressed in testis followed by spleen. Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. Belongs to the NF-kappa-B inhibitor family. protein binding nucleus cytoplasm cytosol signal transduction cytoplasmic sequestering of NF-kappaB cellular response to lipopolysaccharide uc009fzr.1 uc009fzr.2 uc009fzr.3 uc009fzr.4 
ENSMUST00000032818.13 Fbxo17 ENSMUST00000032818.13 F-box protein 17, transcript variant 1 (from RefSeq NM_015796.2) ENSMUST00000032818.1 ENSMUST00000032818.10 ENSMUST00000032818.11 ENSMUST00000032818.12 ENSMUST00000032818.2 ENSMUST00000032818.3 ENSMUST00000032818.4 ENSMUST00000032818.5 ENSMUST00000032818.6 ENSMUST00000032818.7 ENSMUST00000032818.8 ENSMUST00000032818.9 FBX17_MOUSE Fbx17 Fbxo26 NM_015796 Q9QZM8 uc009fzn.1 uc009fzn.2 uc009fzn.3 uc009fzn.4 uc009fzn.5 uc009fzn.6 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high- mannose glycoproteins (By similarity). Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QZM8-1; Sequence=Displayed; Name=2; IsoId=Q9QZM8-2; Sequence=VSP_012981, VSP_012982; Expressed primarily in the brain. protein binding cytoplasm glycoprotein catabolic process protein ubiquitination SCF ubiquitin ligase complex ER-associated ubiquitin-dependent protein catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin protein ligase activity uc009fzn.1 uc009fzn.2 uc009fzn.3 uc009fzn.4 uc009fzn.5 uc009fzn.6 
ENSMUST00000032824.10 Psmc4 ENSMUST00000032824.10 proteasome (prosome, macropain) 26S subunit, ATPase, 4 (from RefSeq NM_011874.2) ENSMUST00000032824.1 ENSMUST00000032824.2 ENSMUST00000032824.3 ENSMUST00000032824.4 ENSMUST00000032824.5 ENSMUST00000032824.6 ENSMUST00000032824.7 ENSMUST00000032824.8 ENSMUST00000032824.9 NM_011874 P54775 PRS6B_MOUSE Q6ZWN9 Tbp7 uc009fxp.1 uc009fxp.2 uc009fxp.3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC4 and few additional components. Interacts with NR1I3. Interacts with PAAF1. Interacts with TRIM5. Interacts with ZFAND1 (By similarity). Cytoplasm Nucleus Belongs to the AAA ATPase family. nucleotide binding proteasome complex blastocyst development ATP binding nucleus cytoplasm cytosol proteasome regulatory particle, base subcomplex inclusion body hydrolase activity proteasome accessory complex protein catabolic process cytosolic proteasome complex proteasome-activating ATPase activity synapse positive regulation of RNA polymerase II transcriptional preinitiation complex assembly positive regulation of proteasomal protein catabolic process uc009fxp.1 uc009fxp.2 uc009fxp.3 
ENSMUST00000032835.7 Acan ENSMUST00000032835.7 aggrecan, transcript variant 2 (from RefSeq NM_007424.3) Agc Agc1 E9QLS9 ENSMUST00000032835.1 ENSMUST00000032835.2 ENSMUST00000032835.3 ENSMUST00000032835.4 ENSMUST00000032835.5 ENSMUST00000032835.6 NM_007424 PGCA_MOUSE Q61282 Q64021 uc009hxw.1 uc009hxw.2 This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. Interacts with COMP (By similarity). Interacts with FBLN1. Secreted, extracellular space, extracellular matrix Specifically expressed in cartilage tissues. Expressed in chondrocytes throughout the developing skeleton in a pattern very similar but not identical to those of type II and IX collagen. In the newborn mouse skeleton it is expressed essentially in a mutually exclusive manner with tenascin, which is expressed osteoblasts, periosteal and perichondrial cells, and in cells at articular surfaces. Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C- terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3. Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. Note=Defects in Acan are the cause of cartilage matrix deficiency (CMD). CMD is an autosomal recessive syndrome characterized by cleft palate, short limbs, tail and snout. Mutation in strain CMD causes absence of aggrecan by truncation of the protein (mutation in the G1 domain). Belongs to the aggrecan/versican proteoglycan family. Name=Functional Glycomics Gateway - Glycan Binding; Note=Aggrecan; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_283"; skeletal system development cartilage condensation chondrocyte development calcium ion binding protein binding hyaluronic acid binding extracellular region basement membrane extracellular space cell adhesion central nervous system development heart development proteoglycan biosynthetic process collagen fibril organization carbohydrate binding negative regulation of cell migration extracellular matrix neuron projection neuronal cell body metal ion binding perineuronal net perisynaptic extracellular matrix glutamatergic synapse GABA-ergic synapse uc009hxw.1 uc009hxw.2 
ENSMUST00000032839.13 Det1 ENSMUST00000032839.13 DET1 partner of COP1 E3 ubiquitin ligase, transcript variant 12 (from RefSeq NR_185012.1) DET1_MOUSE ENSMUST00000032839.1 ENSMUST00000032839.10 ENSMUST00000032839.11 ENSMUST00000032839.12 ENSMUST00000032839.2 ENSMUST00000032839.3 ENSMUST00000032839.4 ENSMUST00000032839.5 ENSMUST00000032839.6 ENSMUST00000032839.7 ENSMUST00000032839.8 ENSMUST00000032839.9 NR_185012 Q9D0A0 uc009hxo.1 uc009hxo.2 uc009hxo.3 Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation (By similarity). Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. Nucleus Belongs to the DET1 family. nucleus protein ubiquitination Cul4A-RING E3 ubiquitin ligase complex ubiquitin protein ligase binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process macromolecular complex binding macromolecular complex assembly Cul4-RING E3 ubiquitin ligase complex protein binding, bridging involved in substrate recognition for ubiquitination uc009hxo.1 uc009hxo.2 uc009hxo.3 
ENSMUST00000032840.5 Mrps11 ENSMUST00000032840.5 mitochondrial ribosomal protein S11, transcript variant 3 (from RefSeq NR_153793.1) ENSMUST00000032840.1 ENSMUST00000032840.2 ENSMUST00000032840.3 ENSMUST00000032840.4 Mrps11 NR_153793 Q3U8Y1 Q3U8Y1_MOUSE uc009hxm.1 uc009hxm.2 uc009hxm.3 uc009hxm.4 Belongs to the universal ribosomal protein uS11 family. structural constituent of ribosome mitochondrion mitochondrial small ribosomal subunit ribosome translation uc009hxm.1 uc009hxm.2 uc009hxm.3 uc009hxm.4 
ENSMUST00000032841.7 Mrpl46 ENSMUST00000032841.7 mitochondrial ribosomal protein L46 (from RefSeq NM_023331.2) ENSMUST00000032841.1 ENSMUST00000032841.2 ENSMUST00000032841.3 ENSMUST00000032841.4 ENSMUST00000032841.5 ENSMUST00000032841.6 NM_023331 Q9EQI8 RM46_MOUSE uc009hxl.1 uc009hxl.2 uc009hxl.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mL46 family. structural constituent of ribosome nucleoplasm mitochondrion mitochondrial large ribosomal subunit ribosome biological_process hydrolase activity cell junction uc009hxl.1 uc009hxl.2 uc009hxl.3 
ENSMUST00000032842.13 Ccdc90b ENSMUST00000032842.13 coiled-coil domain containing 90B, transcript variant 1 (from RefSeq NM_025515.3) CC90B_MOUSE ENSMUST00000032842.1 ENSMUST00000032842.10 ENSMUST00000032842.11 ENSMUST00000032842.12 ENSMUST00000032842.2 ENSMUST00000032842.3 ENSMUST00000032842.4 ENSMUST00000032842.5 ENSMUST00000032842.6 ENSMUST00000032842.7 ENSMUST00000032842.8 ENSMUST00000032842.9 NM_025515 Q8C3X2 Q8JZY3 Q9D7C1 uc009ihv.1 uc009ihv.2 uc009ihv.3 Interacts with MCU. Mitochondrion membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C3X2-1; Sequence=Displayed; Name=2; IsoId=Q8C3X2-2; Sequence=VSP_027004; Belongs to the CCDC90 family. molecular_function mitochondrion biological_process membrane integral component of membrane mitochondrial membrane uc009ihv.1 uc009ihv.2 uc009ihv.3 
ENSMUST00000032843.9 Tmem126b ENSMUST00000032843.9 transmembrane protein 126B (from RefSeq NM_026734.2) ENSMUST00000032843.1 ENSMUST00000032843.2 ENSMUST00000032843.3 ENSMUST00000032843.4 ENSMUST00000032843.5 ENSMUST00000032843.6 ENSMUST00000032843.7 ENSMUST00000032843.8 NM_026734 Q9D1R1 T126B_MOUSE Tmem126b uc009ihp.1 uc009ihp.2 uc009ihp.3 uc009ihp.4 As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. Participates in constructing the membrane arm of complex I. Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186. Associates with the intermediate 370 kDa subcomplex of incompletely assembled complex I. Interacts with TMEM70 (By similarity). Mitochondrion membrane ; Multi-pass membrane protein Belongs to the TMEM126 family. molecular_function mitochondrion membrane integral component of membrane mitochondrial membrane mitochondrial respiratory chain complex I assembly uc009ihp.1 uc009ihp.2 uc009ihp.3 uc009ihp.4 
ENSMUST00000032844.7 Tmem126a ENSMUST00000032844.7 transmembrane protein 126A, transcript variant 1 (from RefSeq NM_025460.3) ENSMUST00000032844.1 ENSMUST00000032844.2 ENSMUST00000032844.3 ENSMUST00000032844.4 ENSMUST00000032844.5 ENSMUST00000032844.6 NM_025460 Q9D8Y1 T126A_MOUSE uc009ihn.1 uc009ihn.2 uc009ihn.3 Mitochondrion inner membrane ; Multi-pass membrane protein In the retina, significant levels of expression are detected in the ganglion cell layer, the optic nerve head, the outer plexiform layer, and in the outer ellipsoide length of photoreceptor inner segments. Belongs to the TMEM126 family. molecular_function mitochondrion mitochondrial inner membrane membrane integral component of membrane optic nerve development uc009ihn.1 uc009ihn.2 uc009ihn.3 
ENSMUST00000032856.13 Me3 ENSMUST00000032856.13 malic enzyme 3, NADP(+)-dependent, mitochondrial (from RefSeq NM_181407.5) ENSMUST00000032856.1 ENSMUST00000032856.10 ENSMUST00000032856.11 ENSMUST00000032856.12 ENSMUST00000032856.2 ENSMUST00000032856.3 ENSMUST00000032856.4 ENSMUST00000032856.5 ENSMUST00000032856.6 ENSMUST00000032856.7 ENSMUST00000032856.8 ENSMUST00000032856.9 MAON_MOUSE NM_181407 Q499F4 Q8BMF3 uc009ige.1 uc009ige.2 uc009ige.3 Reaction=(S)-malate + NADP(+) = CO2 + NADPH + pyruvate; Xref=Rhea:RHEA:18253, ChEBI:CHEBI:15361, ChEBI:CHEBI:15589, ChEBI:CHEBI:16526, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.40; Reaction=H(+) + oxaloacetate = CO2 + pyruvate; Xref=Rhea:RHEA:15641, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526; EC=1.1.1.40; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Divalent metal cations. Prefers magnesium or manganese. ; Mitochondrion matrix Belongs to the malic enzymes family. malic enzyme activity malate dehydrogenase (decarboxylating) (NAD+) activity malate dehydrogenase (decarboxylating) (NADP+) activity mitochondrion mitochondrial matrix pyruvate metabolic process malate metabolic process oxaloacetate decarboxylase activity oxidoreductase activity metal ion binding NAD binding oxidation-reduction process uc009ige.1 uc009ige.2 uc009ige.3 
ENSMUST00000032865.17 Fah ENSMUST00000032865.17 fumarylacetoacetate hydrolase (from RefSeq NM_010176.4) ENSMUST00000032865.1 ENSMUST00000032865.10 ENSMUST00000032865.11 ENSMUST00000032865.12 ENSMUST00000032865.13 ENSMUST00000032865.14 ENSMUST00000032865.15 ENSMUST00000032865.16 ENSMUST00000032865.2 ENSMUST00000032865.3 ENSMUST00000032865.4 ENSMUST00000032865.5 ENSMUST00000032865.6 ENSMUST00000032865.7 ENSMUST00000032865.8 ENSMUST00000032865.9 FAAA_MOUSE NM_010176 P35505 Q3TY87 Q9QW65 uc009iej.1 uc009iej.2 uc009iej.3 uc009iej.4 Reaction=4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+); Xref=Rhea:RHEA:10244, ChEBI:CHEBI:13705, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18034, ChEBI:CHEBI:29806; EC=3.7.1.2; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6. Homodimer. Mainly in liver and kidney. Belongs to the FAH family. catalytic activity fumarylacetoacetase activity arginine catabolic process L-phenylalanine catabolic process tyrosine catabolic process aromatic amino acid family metabolic process hydrolase activity metal ion binding homogentisate catabolic process uc009iej.1 uc009iej.2 uc009iej.3 uc009iej.4 
ENSMUST00000032874.14 Sh3gl3 ENSMUST00000032874.14 SH3-domain GRB2-like 3, transcript variant 1 (from RefSeq NM_017400.8) A0A0R4J0B8 A0A0R4J0B8_MOUSE ENSMUST00000032874.1 ENSMUST00000032874.10 ENSMUST00000032874.11 ENSMUST00000032874.12 ENSMUST00000032874.13 ENSMUST00000032874.2 ENSMUST00000032874.3 ENSMUST00000032874.4 ENSMUST00000032874.5 ENSMUST00000032874.6 ENSMUST00000032874.7 ENSMUST00000032874.8 ENSMUST00000032874.9 NM_017400 Sh3gl3 uc291sbg.1 uc291sbg.2 Membrane ; Peripheral membrane protein Belongs to the endophilin family. acrosomal vesicle cytoplasm early endosome endocytosis protein C-terminus binding identical protein binding synapse positive regulation of neuron differentiation presynapse postsynaptic endosome glutamatergic synapse postsynaptic density, intracellular component negative regulation of clathrin-dependent endocytosis regulation of clathrin-dependent endocytosis uc291sbg.1 uc291sbg.2 
ENSMUST00000032877.11 Ddias ENSMUST00000032877.11 DNA damage-induced apoptosis suppressor, transcript variant 3 (from RefSeq NM_001368705.1) 4632434I11Rik Ddias E9QLR9 E9QLR9_MOUSE ENSMUST00000032877.1 ENSMUST00000032877.10 ENSMUST00000032877.2 ENSMUST00000032877.3 ENSMUST00000032877.4 ENSMUST00000032877.5 ENSMUST00000032877.6 ENSMUST00000032877.7 ENSMUST00000032877.8 ENSMUST00000032877.9 NM_001368705 uc009iii.1 uc009iii.2 uc009iii.3 uc009iii.4 uc009iii.1 uc009iii.2 uc009iii.3 uc009iii.4 
ENSMUST00000032879.15 Rab30 ENSMUST00000032879.15 RAB30, member RAS oncogene family (from RefSeq NM_029494.2) ENSMUST00000032879.1 ENSMUST00000032879.10 ENSMUST00000032879.11 ENSMUST00000032879.12 ENSMUST00000032879.13 ENSMUST00000032879.14 ENSMUST00000032879.2 ENSMUST00000032879.3 ENSMUST00000032879.4 ENSMUST00000032879.5 ENSMUST00000032879.6 ENSMUST00000032879.7 ENSMUST00000032879.8 ENSMUST00000032879.9 NM_029494 Q3UQR3 Q923S9 Q9D3Q6 RAB30_MOUSE Rsb30 uc009iif.1 uc009iif.2 uc009iif.3 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (By similarity). Membrane ; Lipid-anchor ; Cytoplasmic side Golgi apparatus, trans- Golgi network Cytoplasm Golgi apparatus Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity GTP binding cytoplasm Golgi apparatus cis-Golgi network trans-Golgi network intracellular protein transport Golgi organization membrane Golgi cisterna Rab protein signal transduction intracellular membrane-bounded organelle uc009iif.1 uc009iif.2 uc009iif.3 
ENSMUST00000032882.9 Ndufc2 ENSMUST00000032882.9 NADH:ubiquinone oxidoreductase subunit C2 (from RefSeq NM_024220.2) ENSMUST00000032882.1 ENSMUST00000032882.2 ENSMUST00000032882.3 ENSMUST00000032882.4 ENSMUST00000032882.5 ENSMUST00000032882.6 ENSMUST00000032882.7 ENSMUST00000032882.8 NDUC2_MOUSE NM_024220 Ndufc2 Q3TLB2 Q9CQ54 uc009ijd.1 uc009ijd.2 uc009ijd.3 uc009ijd.4 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Interacts with TMEM242 (By similarity). Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side Belongs to the complex I NDUFC2 subunit family. cytoplasm mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial electron transport, NADH to ubiquinone NADH dehydrogenase (ubiquinone) activity positive regulation of mitochondrial membrane potential membrane integral component of membrane mitochondrial respiratory chain complex I assembly regulation of inflammatory response oxidation-reduction process negative regulation of necrotic cell death respiratory chain negative regulation of NIK/NF-kappaB signaling negative regulation of reactive oxygen species biosynthetic process positive regulation of ATP biosynthetic process uc009ijd.1 uc009ijd.2 uc009ijd.3 uc009ijd.4 
ENSMUST00000032887.4 Coq7 ENSMUST00000032887.4 demethyl-Q 7, transcript variant 1 (from RefSeq NM_009940.4) COQ7_MOUSE Coq7 ENSMUST00000032887.1 ENSMUST00000032887.2 ENSMUST00000032887.3 NM_009940 P97478 Q9R0D7 uc009jjy.1 uc009jjy.2 uc009jjy.3 Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides (By similarity). Involved in lifespan determination in a ubiquinone-independent manner (PubMed:19478076). Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis. Reaction=a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O; Xref=Rhea:RHEA:50908, Rhea:RHEA-COMP:10859, Rhea:RHEA-COMP:10914, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:84167, ChEBI:CHEBI:84422; EC=1.14.99.60; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Note=Binds 2 iron ions per subunit. ; Cofactor biosynthesis; ubiquinone biosynthesis. Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with COQ8B and COQ6. Interacts with COQ9. Mitochondrion inner membrane eripheral membrane protein ; Matrix side Highly expressed in tissues with high energy demand such as heart, muscle, liver, and kidney. Mice lacking Coq7 start to die after E8. Heterozygous mutant reveal that the reduction of Coq7 levels in these animals profoundly alters their mitochondrial function despite the fact that ubiquinone production is unaffected. The mitochondria of young mutants heterozygous are dysfunctional, exhibiting reduced energy metabolism and a substantial increase in oxidative stress. In life-span analysis, transgenic expression reverted the extended life span of clk-1 to the comparable level with wild-type control. Belongs to the COQ7 family. negative regulation of transcription from RNA polymerase II promoter age-dependent response to oxidative stress in utero embryonic development neural tube formation chromatin binding monooxygenase activity nucleus mitochondrion mitochondrial inner membrane ubiquinone biosynthetic process response to oxidative stress determination of adult lifespan 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity regulation of gene expression membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen neurogenesis respiratory electron transport chain extrinsic component of mitochondrial inner membrane cellular response to oxidative stress mitochondrial ATP synthesis coupled electron transport positive regulation of transcription from RNA polymerase II promoter metal ion binding oxidation-reduction process mitochondrion morphogenesis regulation of reactive oxygen species metabolic process uc009jjy.1 uc009jjy.2 uc009jjy.3 
ENSMUST00000032888.10 Arl6ip1 ENSMUST00000032888.10 ADP-ribosylation factor-like 6 interacting protein 1 (from RefSeq NM_019419.2) AR6P1_MOUSE Arl6ip ENSMUST00000032888.1 ENSMUST00000032888.2 ENSMUST00000032888.3 ENSMUST00000032888.4 ENSMUST00000032888.5 ENSMUST00000032888.6 ENSMUST00000032888.7 ENSMUST00000032888.8 ENSMUST00000032888.9 NM_019419 Q9JKW0 Q9JLI9 Q9WUG3 uc009jjo.1 uc009jjo.2 uc009jjo.3 uc009jjo.4 Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity- dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (PubMed:18684713). Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (By similarity). Homooligomer (By similarity). Heterodimer with ARL6IP5 (PubMed:18684713). Interacts with ARL6 (PubMed:10508919). Interacts with TMEM33. Interacts with ATL1 (By similarity). Endomembrane system ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Endoplasmic reticulum Note=Predominantly localized to intracytoplasmic membranes. Preferentially localizes at the ER tubules and the edge of the ER sheets, both of which are characterized by a high membrane curvature. Expressed in the cerebral cortex, cerebellum, hippocampus, olfactory bulbs, medulla oblongate and limbic system (at protein level). Ubiquitous (PubMed:18684713). Expressed in all hematopoietic cell lineages, with highest levels in early myeloid progenitor cells. The transmembrane domains are required for its ability to shape the endoplasmic reticulum membrane into tubules. Belongs to the ARL6ip family. Sequence=AAD33046.1; Type=Frameshift; Evidence=; Sequence=AAF27313.1; Type=Erroneous initiation; Evidence=; positive regulation of L-glutamate transport protein binding cytoplasm endoplasmic reticulum Sec61 translocon complex endoplasmic reticulum membrane cytosol cotranslational protein targeting to membrane apoptotic process endomembrane system membrane integral component of membrane integral component of endoplasmic reticulum membrane identical protein binding negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process endoplasmic reticulum tubular network assembly endoplasmic reticulum tubular network membrane organization uc009jjo.1 uc009jjo.2 uc009jjo.3 uc009jjo.4 
ENSMUST00000032891.15 Smg1 ENSMUST00000032891.15 SMG1 nonsense mediated mRNA decay associated PI3K related kinase (from RefSeq NM_001031814.1) Atx E9QLR6 ENSMUST00000032891.1 ENSMUST00000032891.10 ENSMUST00000032891.11 ENSMUST00000032891.12 ENSMUST00000032891.13 ENSMUST00000032891.14 ENSMUST00000032891.2 ENSMUST00000032891.3 ENSMUST00000032891.4 ENSMUST00000032891.5 ENSMUST00000032891.6 ENSMUST00000032891.7 ENSMUST00000032891.8 ENSMUST00000032891.9 Kiaa0421 Lip NM_001031814 Q5DU42 Q6ZQC0 Q8BKX6 Q8BLU4 Q8BWJ5 Q8BXD3 SMG1_MOUSE Smg1 uc009jjp.1 uc009jjp.2 uc009jjp.3 Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense- mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Inhibited by caffeine, LY294002 and wortmannin. Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Part of a complex composed of SMG1, DHX34 and UPF1; within the complex DHX34 acts as a scaffolding protein to facilitate SMG1 phosphorylation of UPF1 (By similarity). Interacts with PRKCI. Interacts with TELO2 and TTI1. Interacts with RUVBL1 and RUVBL2. Interacts with DHX34 (via C-terminus); the interaction is RNA- independent (By similarity). Nucleus Cytoplasm Note=Present in the chromatoid body. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BKX6-1; Sequence=Displayed; Name=2; IsoId=Q8BKX6-2; Sequence=VSP_017749, VSP_017750; Name=3; IsoId=Q8BKX6-3; Sequence=VSP_017751, VSP_017752; Autophosphorylated. Belongs to the PI3/PI4-kinase family. Sequence=BAD90238.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein serine/threonine kinase activity ATP binding nucleus nucleoplasm cytoplasm DNA repair cellular response to DNA damage stimulus kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation regulation of telomere maintenance telomeric DNA binding protein autophosphorylation phosphatidylinositol phosphorylation metal ion binding regulation of response to DNA damage stimulus uc009jjp.1 uc009jjp.2 uc009jjp.3 
ENSMUST00000032892.7 Xylt1 ENSMUST00000032892.7 xylosyltransferase 1 (from RefSeq NM_175645.3) ENSMUST00000032892.1 ENSMUST00000032892.2 ENSMUST00000032892.3 ENSMUST00000032892.4 ENSMUST00000032892.5 ENSMUST00000032892.6 F8VPK6 F8VPK6_MOUSE NM_175645 Xylt1 uc009jjm.1 uc009jjm.2 uc009jjm.3 Reaction=L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)- L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:50192, Rhea:RHEA- COMP:9863, Rhea:RHEA-COMP:12567, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:132085; EC=2.4.2.26; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis. Monomer. Golgi apparatus membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 14 family. XylT subfamily. Golgi membrane extracellular space glycosaminoglycan biosynthetic process acetylglucosaminyltransferase activity heparan sulfate proteoglycan biosynthetic process membrane integral component of membrane protein xylosyltransferase activity proteoglycan biosynthetic process chondroitin sulfate proteoglycan biosynthetic process uc009jjm.1 uc009jjm.2 uc009jjm.3 
ENSMUST00000032895.15 Nucb2 ENSMUST00000032895.15 nucleobindin 2, transcript variant 2 (from RefSeq NM_001360375.1) ENSMUST00000032895.1 ENSMUST00000032895.10 ENSMUST00000032895.11 ENSMUST00000032895.12 ENSMUST00000032895.13 ENSMUST00000032895.14 ENSMUST00000032895.2 ENSMUST00000032895.3 ENSMUST00000032895.4 ENSMUST00000032895.5 ENSMUST00000032895.6 ENSMUST00000032895.7 ENSMUST00000032895.8 ENSMUST00000032895.9 NM_001360375 NUCB2_MOUSE Nefa P81117 uc009jjk.1 uc009jjk.2 uc009jjk.3 uc009jjk.4 uc009jjk.5 Calcium-binding protein which may have a role in calcium homeostasis (PubMed:10915798). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunit GNAI3 (By similarity). Preferentially interacts with inactive rather than active GNAI3 (By similarity). Interaction with GNAI3 is inhibited when NUCB2 binds calcium, probably due to a conformational change which renders the GBA motif inaccessible (By similarity). Binds to the postmitotic growth suppressor NDN; coexpression abolishes NUCB2 secretion (PubMed:10915798). Cytoplasm Perikaryon Endoplasmic reticulum Golgi apparatus Nucleus envelope Membrane ; Peripheral membrane protein Secreted Note=In dendrites and perikarya of brain neurons. Abundant in the ER cisternae and nuclear envelope, but not detected in Golgi, mitochondria or nucleoplasm in neurons. In cell culture, cytoplasmic and secreted. [Nesfatin-1]: Secreted Found in liver, heart, thymus, muscle, intestine, kidney, lung, spleen and throughout the brain, in cerebral cortex, hippocampus, hypothalamus and medulla oblongata. Nucb2 and necdin levels were higher in postmitotic neurons. The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins). Belongs to the nucleobindin family. DNA binding tumor necrosis factor receptor binding calcium ion binding extracellular region extracellular space nucleus nuclear envelope nuclear outer membrane cytoplasm endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus Golgi medial cisterna cellular calcium ion homeostasis membrane negative regulation of appetite perikaryon negative regulation of cAMP-mediated signaling negative regulation of fat cell differentiation positive regulation of fatty acid oxidation negative regulation of insulin receptor signaling pathway metal ion binding negative regulation of glucagon secretion insulin metabolic process positive regulation of testosterone secretion uc009jjk.1 uc009jjk.2 uc009jjk.3 uc009jjk.4 uc009jjk.5 
ENSMUST00000032898.9 Ipo5 ENSMUST00000032898.9 importin 5, transcript variant 1 (from RefSeq NM_023579.5) ENSMUST00000032898.1 ENSMUST00000032898.2 ENSMUST00000032898.3 ENSMUST00000032898.4 ENSMUST00000032898.5 ENSMUST00000032898.6 ENSMUST00000032898.7 ENSMUST00000032898.8 IPO5_MOUSE Kpnb3 NM_023579 Q3TEG2 Q7TQC6 Q8BKC5 Q9EQ30 Ranbp5 uc007uzz.1 uc007uzz.2 uc007uzz.3 uc007uzz.4 Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (PubMed:22730302). Interacts with RPS7 and RPL5 (By similarity). Directly interacts with RPL23A (via BIB domain) (By similarity). Interacts with H2A, H2B, H3 and H4 histones (PubMed:11493596). Interacts with CPEB3; this mediates CPEB3 nuclear import following neuronal stimulation which enhances the interaction in a RAN-regulated manner (By similarity). Interacts with AIFM2; this interaction likely mediates the translocation of AIFM2 into the nucleus upon oxidative stress (By similarity). Interacts with STX3 (isoform 3) (PubMed:26689472). Interacts with SRP19 (By similarity). Q8BKC5; P70315: Was; NbExp=8; IntAct=EBI-643605, EBI-644195; Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BKC5-1; Sequence=Displayed; Name=2; IsoId=Q8BKC5-2; Sequence=VSP_009658; Belongs to the importin beta family. Importin beta-3 subfamily. Sequence=AAG45965.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding nucleus cytoplasm protein import into nucleus NLS-bearing protein import into nucleus ribosomal protein import into nucleus intracellular protein transport nuclear localization sequence binding Ran GTPase binding protein transport positive regulation of protein import into nucleus nuclear import signal receptor activity cellular response to amino acid stimulus uc007uzz.1 uc007uzz.2 uc007uzz.3 uc007uzz.4 
ENSMUST00000032899.12 1110004F10Rik ENSMUST00000032899.12 RIKEN cDNA 1110004F10 gene, transcript variant 1 (from RefSeq NM_019772.3) ENSMUST00000032899.1 ENSMUST00000032899.10 ENSMUST00000032899.11 ENSMUST00000032899.2 ENSMUST00000032899.3 ENSMUST00000032899.4 ENSMUST00000032899.5 ENSMUST00000032899.6 ENSMUST00000032899.7 ENSMUST00000032899.8 ENSMUST00000032899.9 NM_019772 Q9R0P4 SMAP_MOUSE Sid2057 Smap uc009jix.1 uc009jix.2 uc009jix.3 Belongs to the SMAP family. molecular_function cellular_component biological_process uc009jix.1 uc009jix.2 uc009jix.3 
ENSMUST00000032900.5 Sox6os ENSMUST00000032900.5 SRY (sex determining region Y)-box 6, opposite strand (from RefSeq NR_152104.1) ENSMUST00000032900.1 ENSMUST00000032900.2 ENSMUST00000032900.3 ENSMUST00000032900.4 NR_152104 uc291usa.1 uc291usa.2 uc291usa.3 uc291usa.1 uc291usa.2 uc291usa.3 
ENSMUST00000032902.11 Calcb ENSMUST00000032902.11 calcitonin-related polypeptide, beta (from RefSeq NM_054084.2) Calcb ENSMUST00000032902.1 ENSMUST00000032902.10 ENSMUST00000032902.2 ENSMUST00000032902.3 ENSMUST00000032902.4 ENSMUST00000032902.5 ENSMUST00000032902.6 ENSMUST00000032902.7 ENSMUST00000032902.8 ENSMUST00000032902.9 NM_054084 Q3UW96 Q3UW96_MOUSE uc009jih.1 uc009jih.2 uc009jih.3 Belongs to the calcitonin family. hormone activity extracellular region signal transduction uc009jih.1 uc009jih.2 uc009jih.3 
ENSMUST00000032906.11 Calca ENSMUST00000032906.11 calcitonin/calcitonin-related polypeptide, alpha, transcript variant 3 (from RefSeq NM_001289444.1) CALCA_MOUSE Calc ENSMUST00000032906.1 ENSMUST00000032906.10 ENSMUST00000032906.2 ENSMUST00000032906.3 ENSMUST00000032906.4 ENSMUST00000032906.5 ENSMUST00000032906.6 ENSMUST00000032906.7 ENSMUST00000032906.8 ENSMUST00000032906.9 NM_001289444 Q99JA0 uc009jif.1 uc009jif.2 uc009jif.3 This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either calcitonin or CGRP preproproteins. Post-translational processing of the calcitonin and CGRP propeptides results in either calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. [provided by RefSeq, Mar 2015]. CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP (By similarity). Secreted. Event=Alternative splicing; Named isoforms=2; Name=Calcitonin-gene related peptide I; IsoId=Q99JA0-1; Sequence=Displayed; Name=Calcitonin; IsoId=P70160-1; Sequence=External; Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult. Belongs to the calcitonin family. neurological system process involved in regulation of systemic arterial blood pressure vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure regulation of heart rate receptor binding hormone activity extracellular region extracellular space nucleus cytoplasm cellular calcium ion homeostasis inflammatory response adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity neuropeptide signaling pathway feeding behavior regulation of heart contraction response to heat negative regulation of ossification axon negative regulation of neurological system process calcitonin receptor binding vasodilation neuron projection neuronal cell body terminal bouton negative regulation of blood pressure positive regulation of ossification negative regulation of smooth muscle contraction sperm capacitation response to pain detection of temperature stimulus involved in sensory perception of pain regulation of cytosolic calcium ion concentration cellular response to nerve growth factor stimulus regulation of blood pressure uc009jif.1 uc009jif.2 uc009jif.3 
ENSMUST00000032908.15 Cyp2r1 ENSMUST00000032908.15 cytochrome P450, family 2, subfamily r, polypeptide 1, transcript variant 1 (from RefSeq NM_177382.4) CP2R1_MOUSE ENSMUST00000032908.1 ENSMUST00000032908.10 ENSMUST00000032908.11 ENSMUST00000032908.12 ENSMUST00000032908.13 ENSMUST00000032908.14 ENSMUST00000032908.2 ENSMUST00000032908.3 ENSMUST00000032908.4 ENSMUST00000032908.5 ENSMUST00000032908.6 ENSMUST00000032908.7 ENSMUST00000032908.8 ENSMUST00000032908.9 NM_177382 Q6VVW9 uc009jid.1 uc009jid.2 uc009jid.3 uc009jid.4 A cytochrome P450 monooxygenase involved in activation of vitamin D precursors (PubMed:12867411, PubMed:24019477). Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol). Can metabolize vitamin D analogs/prodrugs 1alpha- hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:12867411, PubMed:24019477) (By similarity). Reaction=calciol + O2 + reduced [NADPH--hemoprotein reductase] = calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:32903, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17933, ChEBI:CHEBI:28940, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32904; Evidence=; Reaction=O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 = 25- hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46580, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:28934, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:86319; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46581; Evidence=; Reaction=1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] = 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46584, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:4712, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:86320; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46585; Evidence=; Reaction=alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] = calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49272, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17823, ChEBI:CHEBI:31186, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49273; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Hormone biosynthesis; vitamin D biosynthesis. Homodimer. Endoplasmic reticulum membrane ; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein. Highly expressed in the liver and testis. Mutant mice are born at the expected Mendelian rate and have normal development. They display substantial reduction of serum calcidiol levels. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity response to metal ion response to cesium ion response to ionizing radiation membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding vitamin D3 25-hydroxylase activity organelle membrane calcitriol biosynthetic process from calciol vitamin D metabolic process vitamin D biosynthetic process exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc009jid.1 uc009jid.2 uc009jid.3 uc009jid.4 
ENSMUST00000032909.9 Pde3b ENSMUST00000032909.9 phosphodiesterase 3B, cGMP-inhibited (from RefSeq NM_011055.2) E9QLQ3 E9QLQ3_MOUSE ENSMUST00000032909.1 ENSMUST00000032909.2 ENSMUST00000032909.3 ENSMUST00000032909.4 ENSMUST00000032909.5 ENSMUST00000032909.6 ENSMUST00000032909.7 ENSMUST00000032909.8 NM_011055 Pde3b uc009jic.1 uc009jic.2 uc009jic.3 Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Belongs to the cyclic nucleotide phosphodiesterase family. 3',5'-cyclic-nucleotide phosphodiesterase activity negative regulation of cell adhesion signal transduction phosphoric diester hydrolase activity membrane integral component of membrane negative regulation of angiogenesis hydrolase activity guanyl-nucleotide exchange factor complex metal ion binding negative regulation of lipid catabolic process uc009jic.1 uc009jic.2 uc009jic.3 
ENSMUST00000032910.13 Mylpf ENSMUST00000032910.13 myosin light chain, phosphorylatable, fast skeletal muscle, transcript variant 1 (from RefSeq NM_016754.5) ENSMUST00000032910.1 ENSMUST00000032910.10 ENSMUST00000032910.11 ENSMUST00000032910.12 ENSMUST00000032910.2 ENSMUST00000032910.3 ENSMUST00000032910.4 ENSMUST00000032910.5 ENSMUST00000032910.6 ENSMUST00000032910.7 ENSMUST00000032910.8 ENSMUST00000032910.9 Mylpf NM_016754 Q545G1 Q545G1_MOUSE uc009jup.1 uc009jup.2 uc009jup.3 uc009jup.4 Myosin is a hexamer of 2 heavy chains and 4 light chains. calcium ion binding immune response skeletal muscle tissue development uc009jup.1 uc009jup.2 uc009jup.3 uc009jup.4 
ENSMUST00000032912.6 Qprt ENSMUST00000032912.6 quinolinate phosphoribosyltransferase (from RefSeq NM_133686.1) ENSMUST00000032912.1 ENSMUST00000032912.2 ENSMUST00000032912.3 ENSMUST00000032912.4 ENSMUST00000032912.5 NADC_MOUSE NM_133686 Q91X91 uc009jug.1 uc009jug.2 uc009jug.3 Involved in the catabolism of quinolinic acid (QA). Reaction=CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5- phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate; Xref=Rhea:RHEA:12733, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29959, ChEBI:CHEBI:33019, ChEBI:CHEBI:57502, ChEBI:CHEBI:58017; EC=2.4.2.19; Evidence=; Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D- ribonucleotide from quinolinate: step 1/1. Hexamer formed by 3 homodimers. Belongs to the NadC/ModD family. catalytic activity nicotinate-nucleotide diphosphorylase (carboxylating) activity cytoplasm NAD biosynthetic process transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups pyridine nucleotide biosynthetic process quinolinate catabolic process protein homodimerization activity quinolinate metabolic process protein oligomerization uc009jug.1 uc009jug.2 uc009jug.3 
ENSMUST00000032915.8 Kif22 ENSMUST00000032915.8 kinesin family member 22, transcript variant 1 (from RefSeq NM_145588.2) ENSMUST00000032915.1 ENSMUST00000032915.2 ENSMUST00000032915.3 ENSMUST00000032915.4 ENSMUST00000032915.5 ENSMUST00000032915.6 ENSMUST00000032915.7 KIF22_MOUSE NM_145588 O35232 Q3V300 Q99LC7 uc009jud.1 uc009jud.2 uc009jud.3 Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. Interacts with FAM83D and SIAH1. Nucleus Cytoplasm, cytoskeleton Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding chromatin DNA binding microtubule motor activity ATP binding nucleus cytoplasm spindle cytosol cytoskeleton kinesin complex microtubule DNA repair microtubule-based movement sister chromatid cohesion mitotic metaphase plate congression microtubule binding nuclear speck ATPase activity metaphase plate congression mitotic spindle uc009jud.1 uc009jud.2 uc009jud.3 
ENSMUST00000032920.5 Cdipt ENSMUST00000032920.5 CDP-diacylglycerol--inositol 3-phosphatidyltransferase, transcript variant 1 (from RefSeq NM_026638.4) CDIPT_MOUSE Cdipt ENSMUST00000032920.1 ENSMUST00000032920.2 ENSMUST00000032920.3 ENSMUST00000032920.4 NM_026638 Pis1 Q8VDP6 uc009jtv.1 uc009jtv.2 uc009jtv.3 uc009jtv.4 Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. Reaction=a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn- glycero-3-phospho-(1D-myo-inositol) + CMP + H(+); Xref=Rhea:RHEA:11580, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268, ChEBI:CHEBI:57880, ChEBI:CHEBI:58332, ChEBI:CHEBI:60377; EC=2.7.8.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11581; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:11582; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Catalytic activity is higher with Mg(2+). ; Endoplasmic reticulum membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Belongs to the CDP-alcohol phosphatidyltransferase class-I family. Golgi membrane CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane lipid metabolic process phosphatidylinositol biosynthetic process phospholipid biosynthetic process membrane integral component of membrane transferase activity phosphotransferase activity, for other substituted phosphate groups diacylglycerol binding manganese ion binding carbohydrate binding alcohol binding CDP-diacylglycerol metabolic process uc009jtv.1 uc009jtv.2 uc009jtv.3 uc009jtv.4 
ENSMUST00000032924.6 Kctd13 ENSMUST00000032924.6 potassium channel tetramerisation domain containing 13 (from RefSeq NM_172747.2) BACD1_MOUSE ENSMUST00000032924.1 ENSMUST00000032924.2 ENSMUST00000032924.3 ENSMUST00000032924.4 ENSMUST00000032924.5 NM_172747 Poldip1 Q6AXE9 Q8BGV7 uc009jtm.1 uc009jtm.2 uc009jtm.3 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:29088697). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission (PubMed:29088697). Protein modification; protein ubiquitination. Homotetramer; forms a two-fold symmetric tetramer in solution. Interacts with CUL3; interaction is direct and forms a 5:5 heterodecamer. Component of the BCR(KCTD13) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD13/BACURD1 and RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with POLD2 and PCNA. Interacts with SPRTN. Nucleus By TNF-alpha. Reduced synaptic transmission in area CA1 of the hippocampus caused by increased levels of RHOA. Brain size or neural progenitor cell proliferation are not affected. Belongs to the BACURD family. Down-regulation of Kctd13 was initially reported to cause macrocephaly due to increased proliferation (PubMed:22596160). However, it was later shown that deletion of Kctd13 does not cause any change in brain size, embryonic cell proliferation, neurogenesis, or cortical layering/migration (PubMed:29088697). Experimental conditions used may explain discrepancies. A possible explanation being that shRNAs used in the first study, may have affected off-targets. ubiquitin-protein transferase activity nucleus DNA replication cell migration protein ubiquitination nuclear body GTP-Rho binding protein domain specific binding Cul3-RING ubiquitin ligase complex negative regulation of Rho protein signal transduction identical protein binding stress fiber assembly proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of DNA replication positive regulation of synaptic transmission protein homooligomerization neural precursor cell proliferation uc009jtm.1 uc009jtm.2 uc009jtm.3 
ENSMUST00000032926.12 Tmem219 ENSMUST00000032926.12 transmembrane protein 219, transcript variant 2 (from RefSeq NM_028389.1) ENSMUST00000032926.1 ENSMUST00000032926.10 ENSMUST00000032926.11 ENSMUST00000032926.2 ENSMUST00000032926.3 ENSMUST00000032926.4 ENSMUST00000032926.5 ENSMUST00000032926.6 ENSMUST00000032926.7 ENSMUST00000032926.8 ENSMUST00000032926.9 NM_028389 Q9D123 Q9D6H1 TM219_MOUSE uc009jtj.1 uc009jtj.2 uc009jtj.3 Cell death receptor specific for IGFBP3, may mediate caspase- 8-dependent apoptosis upon ligand binding. Interacts with IGFBP3. Interacts with CASP8 (By similarity). Cell membrane ; Single-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D123-1; Sequence=Displayed; Name=2; IsoId=Q9D123-2; Sequence=VSP_032932, VSP_032933, VSP_032934; molecular_function cellular_component plasma membrane apoptotic process biological_process membrane integral component of membrane uc009jtj.1 uc009jtj.2 uc009jtj.3 
ENSMUST00000032936.8 Ppp4c ENSMUST00000032936.8 protein phosphatase 4, catalytic subunit, transcript variant 2 (from RefSeq NM_019674.4) ENSMUST00000032936.1 ENSMUST00000032936.2 ENSMUST00000032936.3 ENSMUST00000032936.4 ENSMUST00000032936.5 ENSMUST00000032936.6 ENSMUST00000032936.7 NM_019674 Ppp4c Q3UNF2 Q3UNF2_MOUSE uc009jss.1 uc009jss.2 uc009jss.3 Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily. phosphoprotein phosphatase activity protein serine/threonine phosphatase activity nucleus cytosol plasma membrane protein dephosphorylation regulation of double-strand break repair via homologous recombination hydrolase activity uc009jss.1 uc009jss.2 uc009jss.3 
ENSMUST00000032944.9 Gdpd3 ENSMUST00000032944.9 glycerophosphodiester phosphodiesterase domain containing 3 (from RefSeq NM_024228.2) ENSMUST00000032944.1 ENSMUST00000032944.2 ENSMUST00000032944.3 ENSMUST00000032944.4 ENSMUST00000032944.5 ENSMUST00000032944.6 ENSMUST00000032944.7 ENSMUST00000032944.8 GDPD3_MOUSE Gde7 Gdpd3 NM_024228 Q99LY2 Q9D1C0 uc009jso.1 uc009jso.2 uc009jso.3 Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:25528375, PubMed:27637550). Shows a preference for 1-O-alkyl- sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso- PC) and N-acylethanolamine lysophospholipids (PubMed:25528375). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine (PubMed:25528375). Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:38975, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57518, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38976; Evidence=; Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O- hexadecyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:41143, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64496, ChEBI:CHEBI:77580; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41144; Evidence=; Reaction=1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl- ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine; Xref=Rhea:RHEA:53184, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71464, ChEBI:CHEBI:137009, ChEBI:CHEBI:137017; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53185; Evidence=; Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)- sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine; Xref=Rhea:RHEA:45544, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74544, ChEBI:CHEBI:85223; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45545; Evidence=; Reaction=H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine; Xref=Rhea:RHEA:56460, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71466, ChEBI:CHEBI:74544, ChEBI:CHEBI:85222; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56461; Evidence=; Reaction=H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine; Xref=Rhea:RHEA:53168, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71464, ChEBI:CHEBI:74544, ChEBI:CHEBI:85217; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53169; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; Lysophospholipase D activity is stimulated by calcium. Loss of lysophospholipase D activity in presence of EDTA. Membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Partially colocalized with CANX (PubMed:25528375). Highly expressed in stomach and kidney. In stomach detected in the glandular epithelium. Predominantly expressed in the stomach (at protein level). Belongs to the glycerophosphoryl diester phosphodiesterase family. Sequence=BC002172; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; lysophospholipase activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phospholipid metabolic process phosphoric diester hydrolase activity membrane integral component of membrane hydrolase activity phosphatidylcholine catabolic process glycerophospholipid catabolic process metal ion binding perinuclear region of cytoplasm uc009jso.1 uc009jso.2 uc009jso.3 
ENSMUST00000032946.10 Rab6a ENSMUST00000032946.10 RAB6A, member RAS oncogene family, transcript variant 2 (from RefSeq NM_024287.5) ENSMUST00000032946.1 ENSMUST00000032946.2 ENSMUST00000032946.3 ENSMUST00000032946.4 ENSMUST00000032946.5 ENSMUST00000032946.6 ENSMUST00000032946.7 ENSMUST00000032946.8 ENSMUST00000032946.9 NM_024287 Q0PD54 Q0PD54_MOUSE Rab6 Rab6A Rab6a uc009ini.1 uc009ini.2 uc009ini.3 Belongs to the small GTPase superfamily. Rab family. Golgi membrane GTPase activity GTP binding Golgi apparatus trans-Golgi network cytosol retrograde vesicle-mediated transport, Golgi to ER membrane peptidyl-cysteine methylation antigen processing and presentation protein domain specific binding cytoplasmic vesicle myosin V binding protein localization to Golgi apparatus early endosome to Golgi transport endosome to plasma membrane transport vesicle uc009ini.1 uc009ini.2 uc009ini.3 
ENSMUST00000032949.14 Coro1a ENSMUST00000032949.14 coronin, actin binding protein 1A, transcript variant 5 (from RefSeq NR_178084.1) Coro1a ENSMUST00000032949.1 ENSMUST00000032949.10 ENSMUST00000032949.11 ENSMUST00000032949.12 ENSMUST00000032949.13 ENSMUST00000032949.2 ENSMUST00000032949.3 ENSMUST00000032949.4 ENSMUST00000032949.5 ENSMUST00000032949.6 ENSMUST00000032949.7 ENSMUST00000032949.8 ENSMUST00000032949.9 NR_178084 Q3U1N0 Q3U1N0_MOUSE uc009jsl.1 uc009jsl.2 uc009jsl.3 uc009jsl.4 Binds actin. Cytoplasm, cell cortex Cytoplasm, cytoskeleton Cytoplasmic vesicle, phagosome membrane Belongs to the WD repeat coronin family. immunological synapse phagolysosome assembly phagocytic cup actin binding actin monomer binding cytoplasm actin filament plasma membrane phagocytosis protein C-terminus binding lamellipodium actin cytoskeleton organization leukocyte chemotaxis cortical actin cytoskeleton cell-substrate adhesion myosin heavy chain binding regulation of actin cytoskeleton organization macromolecular complex protein homodimerization activity natural killer cell degranulation phosphatidylinositol 3-kinase binding phagocytic vesicle positive chemotaxis actin filament binding negative regulation of actin nucleation uc009jsl.1 uc009jsl.2 uc009jsl.3 uc009jsl.4 
ENSMUST00000032955.7 Klk7 ENSMUST00000032955.7 kallikrein related-peptidase 7 (chymotryptic, stratum corneum) (from RefSeq NM_011872.3) ENSMUST00000032955.1 ENSMUST00000032955.2 ENSMUST00000032955.3 ENSMUST00000032955.4 ENSMUST00000032955.5 ENSMUST00000032955.6 KLK7_MOUSE NM_011872 Prss6 Q91VE3 Q9R048 Scce uc009gnt.1 uc009gnt.2 uc009gnt.3 uc009gnt.4 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK029477.1, AK077406.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. Reaction=Cleavage of proteins with aromatic side chains in the P1 position.; EC=3.4.21.117; Inhibited by Zn2+ and Cu2+ at low micromolar concentrations. Inhibited by SERPINA12 (By similarity). Secreted Expressed in skin and, at lower levels, in lung, kidney, brain, heart and spleen. In skin, expressed in high suprabasal keratinocytes and in the luminal parts of hair follicles. Not detected in liver and skeletal muscle. Belongs to the peptidase S1 family. Kallikrein subfamily. positive regulation of antibacterial peptide production serine-type endopeptidase activity extracellular region extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity secretory granule epidermal lamellar body uc009gnt.1 uc009gnt.2 uc009gnt.3 uc009gnt.4 
ENSMUST00000032956.10 Sgf29 ENSMUST00000032956.10 SAGA complex associated factor 29 (from RefSeq NM_029339.3) Ccdc101 ENSMUST00000032956.1 ENSMUST00000032956.2 ENSMUST00000032956.3 ENSMUST00000032956.4 ENSMUST00000032956.5 ENSMUST00000032956.6 ENSMUST00000032956.7 ENSMUST00000032956.8 ENSMUST00000032956.9 NM_029339 Q8R0I6 Q9DA08 SGF29_MOUSE Sgf29 uc009jse.1 uc009jse.2 uc009jse.3 uc009jse.4 Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (By similarity). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (By similarity). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (By similarity). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (By similarity). Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-491' (PubMed:35210392). Interacts with dimethylated and trimethylated 'Lys-4' of histone H3 (H3K4me2 and H3K4me3), with a preference for the trimethylated form (H3K4me3) (By similarity). Component of some SAGA- type complexes. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (By similarity). Interacts with (methylated) CGAS (PubMed:35210392). Interacts with TADA3L, GCN5L2, SUPT3H and MYC (By similarity). Nucleus The SGF29 C-terminal (also named tudor-like) domain mediates binding to methylated 'Lys-4' of histone H3 (H3K4me). Belongs to the SGF29 family. SAGA complex transcription factor activity, RNA polymerase II transcription factor recruiting nucleus Ada2/Gcn5/Ada3 transcription activator complex chromatin organization histone acetylation enzyme binding methylated histone binding histone H3 acetylation protein N-terminus binding RNA polymerase II transcriptional preinitiation complex assembly SAGA-type complex uc009jse.1 uc009jse.2 uc009jse.3 uc009jse.4 
ENSMUST00000032958.14 Ucp3 ENSMUST00000032958.14 uncoupling protein 3 (mitochondrial, proton carrier) (from RefSeq NM_009464.3) ENSMUST00000032958.1 ENSMUST00000032958.10 ENSMUST00000032958.11 ENSMUST00000032958.12 ENSMUST00000032958.13 ENSMUST00000032958.2 ENSMUST00000032958.3 ENSMUST00000032958.4 ENSMUST00000032958.5 ENSMUST00000032958.6 ENSMUST00000032958.7 ENSMUST00000032958.8 ENSMUST00000032958.9 NM_009464 O88293 P56501 Slc25a9 UCP3_MOUSE Ucp3 uc009ina.1 uc009ina.2 Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism (PubMed:10748195, PubMed:10748196). Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis (PubMed:29212043). However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity (PubMed:11707458, PubMed:20363757). Inhibited by purine nucleotides and inorganic phosphate (in vitro). Interacts with HAX1; the interaction is direct and calcium- dependent. Mitochondrion inner membrane ; Multi-pass membrane protein Homozygous knockout mice lacking Ucp3 show no overt phenotype being born at the expected frequency, with no observed signs of abnormality, illness, or increased mortality at up to one year of age. They are not obese and have reduced free fatty acids and glucose serum levels. They show a normal circadian rhythm in body temperature and motor activity and have normal body temperature responses to fasting, stress, thyroid hormone, and cold exposure. The baseline metabolic rate and respiratory exchange ratio are the same in knockout and control mice. However, there is decreased proton leak in the mitochondria over the complete range of metabolic rates studied (PubMed:10748195, PubMed:10748196). Mitochondria are more coupled and the production of reactive oxygen species is increased. No effect on exercise tolerance and fatty acid oxidation is observed (PubMed:10748196). Belongs to the mitochondrial carrier (TC 2.A.29) family. response to superoxide response to hypoxia mitochondrion mitochondrial inner membrane fatty acid metabolic process mitochondrial transport aging response to nutrient response to cold response to activity membrane integral component of membrane oxidative phosphorylation uncoupler activity mitochondrial membrane response to insulin cellular response to hormone stimulus response to steroid hormone response to glucocorticoid hydrogen ion transmembrane transport mitochondrial transmembrane transport adaptive thermogenesis uc009ina.1 uc009ina.2 
ENSMUST00000032961.4 Nupr1 ENSMUST00000032961.4 nuclear protein transcription regulator 1 (from RefSeq NM_019738.1) ENSMUST00000032961.1 ENSMUST00000032961.2 ENSMUST00000032961.3 NM_019738 NUPR1_MOUSE Nupr1 Q9D756 Q9WTK0 uc009jsd.1 uc009jsd.2 uc009jsd.3 Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in regulation of many process namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:11896600, PubMed:19723804, PubMed:23900510, PubMed:27451286, PubMed:22565310, PubMed:20181828). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (By similarity). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (By similarity). Inhibits autophagy- induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (PubMed:11896600). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (By similarity). Coactivator of PAX2 transcription factor activity, both by recruiting the EP300 cofactor to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (By similarity). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (By similarity). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (PubMed:23900510). Also required for LHB expression and ovarian maturation (PubMed:18495683). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (PubMed:16374777). Monomer. Directly interacts with MSL1 and binds MORF4L1, two components of histone acetyltransferase complex; the interaction with MORF4L1 may be mediated by MSL1. Interacts with EP300; this interaction enhances the effect of EP300 on PAX2 transcription factor activity. Interacts with PAXIP1; this interaction prevents PAXIP1 inhibition of PAX2 transcription factor activity. Interacts with COPS5; this interaction allows COPS5-dependent CDKN1B nuclear to cytoplasm translocation. Interacts with RNF2. Interacts with FOXO3; this interaction represses FOXO3 transactivation. Interacts with PTMA; regulates apoptotic process (By similarity). Interacts with MYOD1, EP300 and DDX5; this interaction coordinates the association of anti- proliferative and pro-myogenic proteins at the myogenin promoter (PubMed:19723804). Interacts with TP53; interaction is stress- dependent. Forms a complex with EP300 and TP53; this complex binds CDKN1A promoter leading to transcriptional induction of CDKN1A (By similarity). Nucleus Cytoplasm Cytoplasm, perinuclear region Highly expressed in pancreas and both ovaries and testes. At 14 dpc, highly expressed in brain and the highest level is detected at 16 dpc and 18 dpc. Following birth, levels are barely detectable and stabilize at low levels starting at 20 pnd through adulthood. Transiently induced in G1 phase (PubMed:19723804). Activated in fibroblasts during growth arrest. Rapidly induced in response to adriamycin-induced apoptosis. Inhibited by TP53 (PubMed:11896600). Up- regulated during cuprizone-induced inflammation and demyelination (PubMed:16374777). Phosphorylated. Phosphorylation promotes DNA-binding activity. Acetylated. Knockout NUPR1 mice are viable and seem normal. Mouse embryonic fibroblast grown more rapidly compared to wild type (PubMed:11896600). Knockout NUPR1 mice are fertile. However female present a delay in female sexual maturation and male develop a phenotype similar to Sertoli-cell-only syndrome (SCOS) (PubMed:18495683). Belongs to the NUPR family. acute inflammatory response DNA binding chromatin binding transcription coactivator activity nucleus cytoplasm cytosol protein acetylation cell proliferation negative regulation of cell proliferation male gonad development response to toxic substance regulation of autophagy negative regulation of autophagy negative regulation of cardiac muscle cell apoptotic process acetyltransferase activator activity positive regulation of protein modification process protein-DNA complex skeletal muscle cell differentiation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of catalytic activity negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of neuron apoptotic process negative regulation of cell cycle negative regulation of glycolytic process negative regulation of fibroblast proliferation perinuclear region of cytoplasm negative regulation of epithelial cell proliferation macromolecular complex assembly positive regulation of proteasomal protein catabolic process negative regulation of autophagosome assembly positive regulation of nucleic acid-templated transcription positive regulation of oxidative phosphorylation negative regulation of epithelial cell apoptotic process negative regulation of type B pancreatic cell proliferation regulation of female gonad development positive regulation of intrinsic apoptotic signaling pathway uc009jsd.1 uc009jsd.2 uc009jsd.3 
ENSMUST00000032963.10 Ppme1 ENSMUST00000032963.10 protein phosphatase methylesterase 1 (from RefSeq NM_028292.2) ENSMUST00000032963.1 ENSMUST00000032963.2 ENSMUST00000032963.3 ENSMUST00000032963.4 ENSMUST00000032963.5 ENSMUST00000032963.6 ENSMUST00000032963.7 ENSMUST00000032963.8 ENSMUST00000032963.9 NM_028292 PPME1_MOUSE Pme1 Q3U392 Q3UJX8 Q3UKE0 Q8BVQ5 Q8K311 Q91YR8 Q9CSP7 uc009imu.1 uc009imu.2 uc009imu.3 Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity). Reaction=[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol; Xref=Rhea:RHEA:48548, Rhea:RHEA-COMP:12134, Rhea:RHEA- COMP:12135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:90516, ChEBI:CHEBI:90517; EC=3.1.1.89; Binds PPP2CA and PPP2CB. Ubiquitous. Highly expressed in testis and brain. Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium- transporting ATPase ATP1A1. Belongs to the AB hydrolase superfamily. Sequence=BAE32896.1; Type=Erroneous initiation; Evidence=; catalytic activity protein demethylation hydrolase activity protein kinase binding protein phosphatase binding protein phosphatase 2A binding protein C-terminal methylesterase activity protein methylesterase activity carboxylic ester hydrolase activity uc009imu.1 uc009imu.2 uc009imu.3 
ENSMUST00000032967.4 Lipt2 ENSMUST00000032967.4 lipoyl(octanoyl) transferase 2 (putative) (from RefSeq NM_026010.2) ENSMUST00000032967.1 ENSMUST00000032967.2 ENSMUST00000032967.3 LIPT2_MOUSE Lipt2 NM_026010 Q14C29 Q9CVA5 Q9D009 uc009iml.1 uc009iml.2 uc009iml.3 uc009iml.4 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes such as the protein H of the glycine cleavage system (GCSH) (PubMed:29987032). Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). Reaction=L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)- octanoyl-L-lysyl-[protein]; Xref=Rhea:RHEA:17665, Rhea:RHEA- COMP:9636, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:9928, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:64479, ChEBI:CHEBI:78463, ChEBI:CHEBI:78809; EC=2.3.1.181; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17666; Evidence=; Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier- protein]: step 1/2. Mitochondrion In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. Belongs to the LipB family. protein binding mitochondrion cellular protein modification process protein lipoylation octanoyltransferase activity transferase activity transferase activity, transferring acyl groups ligase activity lipoyl(octanoyl) transferase activity positive regulation of oxygen metabolic process uc009iml.1 uc009iml.2 uc009iml.3 uc009iml.4 
ENSMUST00000032969.14 Pold3 ENSMUST00000032969.14 polymerase (DNA-directed), delta 3, accessory subunit, transcript variant 1 (from RefSeq NM_133692.2) ENSMUST00000032969.1 ENSMUST00000032969.10 ENSMUST00000032969.11 ENSMUST00000032969.12 ENSMUST00000032969.13 ENSMUST00000032969.2 ENSMUST00000032969.3 ENSMUST00000032969.4 ENSMUST00000032969.5 ENSMUST00000032969.6 ENSMUST00000032969.7 ENSMUST00000032969.8 ENSMUST00000032969.9 NM_133692 Pold3 Q8BH76 Q8BH76_MOUSE uc009imj.1 uc009imj.2 uc009imj.3 Nucleus DNA-directed DNA polymerase activity nucleus DNA replication delta DNA polymerase complex DNA biosynthetic process uc009imj.1 uc009imj.2 uc009imj.3 
ENSMUST00000032974.13 Atp2a1 ENSMUST00000032974.13 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (from RefSeq NM_007504.2) AT2A1_MOUSE ENSMUST00000032974.1 ENSMUST00000032974.10 ENSMUST00000032974.11 ENSMUST00000032974.12 ENSMUST00000032974.2 ENSMUST00000032974.3 ENSMUST00000032974.4 ENSMUST00000032974.5 ENSMUST00000032974.6 ENSMUST00000032974.7 ENSMUST00000032974.8 ENSMUST00000032974.9 NM_007504 Q8R429 uc009jrf.1 uc009jrf.2 uc009jrf.3 Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum (PubMed:21697544, PubMed:22961106, PubMed:25640239, PubMed:26816378). Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:21697544, PubMed:22961106, PubMed:25640239, PubMed:26816378). Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.10; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18106; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (PubMed:21697544, PubMed:22961106, PubMed:25640239). Reversibly inhibited by phospholamban (PLN) at low calcium concentrations (By similarity). Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (PubMed:26816378). Interacts with sarcolipin (SLN) (PubMed:21697544, PubMed:22961106). Interacts with phospholamban (PLN) (PubMed:26816378). Interacts with myoregulin (MRLN) (PubMed:25640239). Interacts with DWORF (PubMed:26816378). Interacts with VMP1 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Sarcoplasmic reticulum membrane ; Multi-pass membrane protein Ca(2+) and ATP binding cause major rearrangements of the cytoplasmic and transmembrane domains. According to the E1-E2 model, Ca(2+) binding to the cytosolic domain of the pump in the high-affinity E1 conformation is followed by the ATP-dependent phosphorylation of the active site Asp, giving rise to E1P. A conformational change of the phosphoenzyme gives rise to the low-affinity E2P state that exposes the Ca(2+) ions to the lumenal side and promotes Ca(2+) release. Dephosphorylation of the active site Asp mediates the subsequent return to the E1 conformation. PLN and SLN both have a single transmembrane helix; both occupy a similar binding site on ATP2A1 that is situated between the ATP2A1 transmembrane helices. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. nucleotide binding nucleotide-sugar transmembrane transporter activity calcium-transporting ATPase activity calcium ion binding protein binding ATP binding mitochondrion endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment ion transport calcium ion transport cellular calcium ion homeostasis regulation of muscle contraction regulation of striated muscle contraction hydrogen-exporting ATPase activity, phosphorylative mechanism apoptotic mitochondrial changes nucleobase-containing compound transport membrane integral component of membrane sarcoplasmic reticulum ATPase activity positive regulation of fast-twitch skeletal muscle fiber contraction H zone I band positive regulation of endoplasmic reticulum calcium ion concentration negative regulation of endoplasmic reticulum calcium ion concentration sarcoplasmic reticulum membrane response to endoplasmic reticulum stress protein homodimerization activity intracellular membrane-bounded organelle response to peptide hormone negative regulation of striated muscle contraction metal ion binding perinuclear region of cytoplasm positive regulation of mitochondrial calcium ion concentration maintenance of mitochondrion location intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress sarcoplasmic reticulum calcium ion transport calcium ion import calcium ion transmembrane transport relaxation of skeletal muscle carbohydrate derivative transport positive regulation of calcium-transporting ATPase activity positive regulation of calcium ion import into sarcoplasmic reticulum hydrogen ion transmembrane transport calcium ion import into sarcoplasmic reticulum uc009jrf.1 uc009jrf.2 uc009jrf.3 
ENSMUST00000032977.11 Chrdl2 ENSMUST00000032977.11 chordin-like 2, transcript variant 2 (from RefSeq NM_133709.3) A0A0B4J1E8 A0A0B4J1E8_MOUSE Chrdl2 ENSMUST00000032977.1 ENSMUST00000032977.10 ENSMUST00000032977.2 ENSMUST00000032977.3 ENSMUST00000032977.4 ENSMUST00000032977.5 ENSMUST00000032977.6 ENSMUST00000032977.7 ENSMUST00000032977.8 ENSMUST00000032977.9 NM_133709 uc009imi.1 uc009imi.2 uc009imi.3 Secreted uc009imi.1 uc009imi.2 uc009imi.3 
ENSMUST00000032978.8 Sh2b1 ENSMUST00000032978.8 SH2B adaptor protein 1, transcript variant 2 (from RefSeq NM_011363.3) ENSMUST00000032978.1 ENSMUST00000032978.2 ENSMUST00000032978.3 ENSMUST00000032978.4 ENSMUST00000032978.5 ENSMUST00000032978.6 ENSMUST00000032978.7 NM_011363 O54867 Q05DJ7 Q792R7 Q91ZM2 Q91ZM3 Q91ZV5 Q9WVM5 SH2B1_MOUSE Sh2bpsm1 uc009jrk.1 uc009jrk.2 uc009jrk.3 uc009jrk.4 Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3- kinase pathway. Acts as a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity (By similarity). Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis, according the order: isoform 3 > isoform 4 > isoform 1 > isoform 2. Self-associates. Homopentamer (By similarity). Forms a heteromultimeric complex with SH2B2 (By similarity). Interacts with SH2B2. Isoform 1 interacts via its SH2 domain with JAK2. Isoform 2 interacts via its SH2 domain and its N-terminus with JAK2; the SH2 domain is required for the major interaction with JAK2 phosphorylated on tyrosine residues; the N-terminus provides a low-affinity binding to JAK2 independent of JAK2 phosphorylation. Isoform 3 interacts via its SH2 domain with JAK2. Isoform 1 interacts via its SH2 domain with INSR; the interaction requires receptor activation. Isoform 3 interacts via its SH2 domain with INSR; the interaction requires receptor activation and requires INSR phosphorylation at 'Tyr-1175'. Isoform 1 interacts with IGF1R; the interaction requires receptor activation. Isoform 2 interacts via its SH2 domain with FGFR3; the interaction requires FGFR3 'Tyr-719' and 'Tyr-755'. Isoform 2 interacts with RET; the interaction requires RET kinase activity and RET 'Tyr-982'. Isoform 2 interacts with RAC1. Isoform 2 interacts with PDGFRA and/or PDGFRB; the interaction requires receptor activation. Interacts with ISR1 and ISR2. Isoform 3 is probably part of a complex consisting of INSR, ISR1 and SH2B1. Probably part of a ternary complex consisting of SH2B1, JAK2 and ISR1 or ISR2. May interact with FCER1G (By similarity). Interacts (via SH2 domain) with NTRK1 (phosphorylated) (By similarity). Q91ZM2; Q62120: Jak2; NbExp=3; IntAct=EBI-7178606, EBI-646604; Cytoplasm Membrane Nucleus Note=Shuttles between the nucleus and the cytoplasm. Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Alpha; IsoId=Q91ZM2-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q91ZM2-2; Sequence=VSP_032032; Name=3; Synonyms=Gamma; IsoId=Q91ZM2-3; Sequence=VSP_032033; Name=4; Synonyms=Delta; IsoId=Q91ZM2-4; Sequence=VSP_032034; Name=5; IsoId=Q91ZM2-5; Sequence=VSP_032029, VSP_032031; Name=6; Synonyms=Sh2bpsm1 gamma; IsoId=Q91ZM2-6; Sequence=VSP_032030, VSP_032033; Widely expressed with highest levels in liver, brain and heart. Isoform 3 is widely expressed. Phosphorylated on tyrosine residues in response to IGF-I and PDGF stimulation. Belongs to the SH2B adapter family. ruffle transmembrane receptor protein tyrosine kinase adaptor activity protein binding nucleus cytoplasm cytosol plasma membrane signal transduction transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of signal transduction membrane lamellipodium assembly intracellular signal transduction signaling adaptor activity positive regulation of mitotic nuclear division regulation of DNA biosynthetic process uc009jrk.1 uc009jrk.2 uc009jrk.3 uc009jrk.4 
ENSMUST00000032985.11 Slco2b1 ENSMUST00000032985.11 solute carrier organic anion transporter family, member 2b1, transcript variant 2 (from RefSeq NM_175316.3) ENSMUST00000032985.1 ENSMUST00000032985.10 ENSMUST00000032985.2 ENSMUST00000032985.3 ENSMUST00000032985.4 ENSMUST00000032985.5 ENSMUST00000032985.6 ENSMUST00000032985.7 ENSMUST00000032985.8 ENSMUST00000032985.9 NM_175316 Oatp2b1 Q8BLV8 Q8BXB6 SO2B1_MOUSE Slc21a9 Slco2b1 uc009ily.1 uc009ily.2 Mediates the Na(+)-independent transport of steroid sulfate conjugates such as estrone 3-sulfate (E1S), dehydroepiandrosterone sulfate (DHEA-S) and pregnenolone sulfate (PregS) and other specific organic anions (PubMed:31123035). Responsible for the transport of E1S through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including DHEA-S (By similarity). Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver. Mediates the intestinal uptake of sulfated steroids. Mediates the uptake of the neurosteroids DHEA-S and PregS into the endothelial cells of the blood-brain barrier as the first step to enter the brain. Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons. May act as a heme transporter that promotes cellular iron availability. Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (By similarity). Mediates the uptake of other substrates such as prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), taurocholate, L- thyroxine, leukotriene C4 and thromboxane B2 (PubMed:31123035). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound. Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions. Cytoplasmic glutamate may also act as counteranion in the placenta. An inwardly directed proton gradient has also been proposed as the driving force of E1S uptake with a (H(+):E1S) stoichiometry of (1:1) (By similarity). Reaction=dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 3-sulfate(in); Xref=Rhea:RHEA:71839, ChEBI:CHEBI:57905; Evidence=; Reaction=estrone 3-sulfate(out) = estrone 3-sulfate(in); Xref=Rhea:RHEA:71835, ChEBI:CHEBI:60050; Evidence=; Reaction=estrone 3-sulfate(out) + hydrogencarbonate(in) = estrone 3- sulfate(in) + hydrogencarbonate(out); Xref=Rhea:RHEA:73055, ChEBI:CHEBI:17544, ChEBI:CHEBI:60050; Evidence=; Reaction=taurocholate(out) = taurocholate(in); Xref=Rhea:RHEA:71703, ChEBI:CHEBI:36257; Evidence=; Reaction=coproporphyrin III(out) = coproporphyrin III(in); Xref=Rhea:RHEA:74363, ChEBI:CHEBI:131725; Evidence=; Reaction=substance P(out) = substance P(in); Xref=Rhea:RHEA:74367, ChEBI:CHEBI:190692; Evidence=; Reaction=pregnenolone sulfate(out) = pregnenolone sulfate(in); Xref=Rhea:RHEA:73023, ChEBI:CHEBI:133000; Evidence=; Reaction=prostaglandin E2(out) = prostaglandin E2(in); Xref=Rhea:RHEA:50984, ChEBI:CHEBI:606564; Evidence=; Reaction=prostaglandin D2(out) = prostaglandin D2(in); Xref=Rhea:RHEA:50976, ChEBI:CHEBI:57406; Evidence=; Reaction=L-thyroxine(out) = L-thyroxine(in); Xref=Rhea:RHEA:71819, ChEBI:CHEBI:58448; Evidence=; Cell membrane ; Multi-pass membrane protein Basal cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Expressed in liver, kidney, small intestine mucosa, large intestine, brain, lung, spleen, stomach and heart. A conserved histidine residue in the third transmembrane domain (His-128) might play an essential role in the pH sensitivity of SLCO2B1/OATP2B1-mediated substrate transport. Transmembrane domain 1 (TM1) may be localized within the substrate binding pocket. Knockout mice show no difference in growth rate, viability, fertility, progeny, life span, weight, organs, tissues and serum biochemistry (PubMed:31123035). Knockout females exhibit an increased in Cyp2c65 and Cyp2c66 gene expression, but not males (PubMed:32114507). Knockout mice exhibit a decreased plasma concentration of certain drugs administered orally such as fexofenadine and fluvastatin, whereas no difference were observed after intravenous administration (PubMed:31123035, PubMed:32114507). Also exhibit a decreased in the hepatic uptake of drugs erlotinib and mebrofenin after intravenous injection (PubMed:34205780). Don't show any difference in fluvastatin liver concentration after oral injection (PubMed:32114507). Most likely contributes to the absorption and the disposition of a wide range of drugs in the intestine and the liver. Belongs to the organo anion transporter (TC 2.A.60) family. plasma membrane integral component of plasma membrane ion transport organic anion transmembrane transporter activity basal plasma membrane bile acid transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity organic anion transport bile acid and bile salt transport membrane integral component of membrane apical plasma membrane sodium-independent organic anion transport transmembrane transport sodium-independent icosanoid transport uc009ily.1 uc009ily.2 
ENSMUST00000032992.7 Eif3c ENSMUST00000032992.7 eukaryotic translation initiation factor 3, subunit C (from RefSeq NM_146200.1) EIF3C_MOUSE ENSMUST00000032992.1 ENSMUST00000032992.2 ENSMUST00000032992.3 ENSMUST00000032992.4 ENSMUST00000032992.5 ENSMUST00000032992.6 Eif3s8 NM_146200 Q8R1B4 Q8R3M7 uc009jrw.1 uc009jrw.2 uc009jrw.3 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with ALKBH4, IFIT1 and IFIT2 (By similarity). Interacts with BZW2/5MP1 (By similarity). Cytoplasm Phosphorylated. Phosphorylation is enhanced upon serum stimulation. Belongs to the eIF-3 subunit C family. formation of cytoplasmic translation initiation complex cytoplasmic translational initiation RNA binding translation initiation factor activity cytoplasm eukaryotic translation initiation factor 3 complex translation translational initiation eukaryotic 43S preinitiation complex translation initiation factor binding eukaryotic 48S preinitiation complex ribosome binding positive regulation of translation eukaryotic translation initiation factor 3 complex, eIF3m positive regulation of mRNA binding uc009jrw.1 uc009jrw.2 uc009jrw.3 
ENSMUST00000032994.15 Spns1 ENSMUST00000032994.15 SPNS lysolipid transporter 1, lysophospholipid, transcript variant 1 (from RefSeq NM_023712.3) ENSMUST00000032994.1 ENSMUST00000032994.10 ENSMUST00000032994.11 ENSMUST00000032994.12 ENSMUST00000032994.13 ENSMUST00000032994.14 ENSMUST00000032994.2 ENSMUST00000032994.3 ENSMUST00000032994.4 ENSMUST00000032994.5 ENSMUST00000032994.6 ENSMUST00000032994.7 ENSMUST00000032994.8 ENSMUST00000032994.9 NM_023712 Q3TKM0 Q8R0G7 Q99LN7 Q9EQK0 SPNS1_MOUSE uc009jqy.1 uc009jqy.2 uc009jqy.3 uc009jqy.4 uc009jqy.5 Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol (PubMed:36161949). Mediates the rate- limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids (PubMed:36161949). Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), can also transport lysophosphatidylglycerol (LPG), but not other anionic lysophospholipids, sphingosine, nor sphingomyelin (PubMed:36161949). Transports lysophospholipids with saturated, monounsaturated, and polyunsaturated fatty acids, such as 1-hexadecanoyl-sn-glycero-3- phosphocholine, 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1- (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine, respectively (PubMed:36161949). Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3- phosphocholine. Essential player in lysosomal homeostasis (PubMed:36161949). Crucial for cell survival under conditions of nutrient limitation. May be involved in necrotic or autophagic cell death (By similarity). Reaction=a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) = a 1- acyl-sn-glycero-3-phosphocholine(in) + H(+)(in); Xref=Rhea:RHEA:74435, ChEBI:CHEBI:15378, ChEBI:CHEBI:58168; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in); Xref=Rhea:RHEA:74427, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in); Xref=Rhea:RHEA:74411, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610; Evidence=; Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3- phosphocholine(out) + H(+)(out) = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)- sn-glycero-3-phosphocholine(in) + H(+)(in); Xref=Rhea:RHEA:74451, ChEBI:CHEBI:15378, ChEBI:CHEBI:74344; Evidence=; Reaction=1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3- phosphocholine(out) + H(+)(out) = 1-(4Z,7Z,10Z,13Z,16Z,19Z- docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in); Xref=Rhea:RHEA:74423, ChEBI:CHEBI:15378, ChEBI:CHEBI:73873; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in); Xref=Rhea:RHEA:74439, ChEBI:CHEBI:15378, ChEBI:CHEBI:64381; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in); Xref=Rhea:RHEA:74415, ChEBI:CHEBI:15378, ChEBI:CHEBI:74971; Evidence=; Reaction=1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in); Xref=Rhea:RHEA:74443, ChEBI:CHEBI:15378, ChEBI:CHEBI:64840; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn- glycerol)(in) + H(+)(in); Xref=Rhea:RHEA:74419, ChEBI:CHEBI:15378, ChEBI:CHEBI:72828; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in); Xref=Rhea:RHEA:74447, ChEBI:CHEBI:15378, ChEBI:CHEBI:77287; Evidence=; Reaction=1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in); Xref=Rhea:RHEA:74431, ChEBI:CHEBI:15378, ChEBI:CHEBI:73850; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in); Xref=Rhea:RHEA:74455, ChEBI:CHEBI:15378, ChEBI:CHEBI:77288; Evidence=; Reaction=1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in); Xref=Rhea:RHEA:74459, ChEBI:CHEBI:15378, ChEBI:CHEBI:133139; Evidence=; Interacts with BCL2 and BCL2L1. Lysosome membrane ; Multi-pass membrane protein Expressed in liver (at mRNA and protein levels). Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. mitochondrion mitochondrial inner membrane integral component of plasma membrane lipid transport membrane integral component of membrane transmembrane transport uc009jqy.1 uc009jqy.2 uc009jqy.3 uc009jqy.4 uc009jqy.5 
ENSMUST00000032997.8 Lat ENSMUST00000032997.8 linker for activation of T cells (from RefSeq NM_010689.3) ENSMUST00000032997.1 ENSMUST00000032997.2 ENSMUST00000032997.3 ENSMUST00000032997.4 ENSMUST00000032997.5 ENSMUST00000032997.6 ENSMUST00000032997.7 LAT Lat NM_010689 Q546H1 Q546H1_MOUSE uc009jqx.1 uc009jqx.2 uc009jqx.3 uc009jqx.4 uc009jqx.5 immunological synapse SH3/SH2 adaptor activity Golgi apparatus plasma membrane immune response signal transduction integrin-mediated signaling pathway Ras protein signal transduction positive regulation of signal transduction membrane integral component of membrane calcium-mediated signaling protein kinase binding intracellular signal transduction positive regulation of protein kinase activity regulation of T cell activation uc009jqx.1 uc009jqx.2 uc009jqx.3 uc009jqx.4 uc009jqx.5 
ENSMUST00000032998.13 Rps3 ENSMUST00000032998.13 ribosomal protein S3 (from RefSeq NM_012052.2) ENSMUST00000032998.1 ENSMUST00000032998.10 ENSMUST00000032998.11 ENSMUST00000032998.12 ENSMUST00000032998.2 ENSMUST00000032998.3 ENSMUST00000032998.4 ENSMUST00000032998.5 ENSMUST00000032998.6 ENSMUST00000032998.7 ENSMUST00000032998.8 ENSMUST00000032998.9 NM_012052 Q5YLW3 Q5YLW3_MOUSE Rps3 uc009ilr.1 uc009ilr.2 uc009ilr.3 uc009ilr.4 Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA- COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695, ChEBI:CHEBI:167181; EC=4.2.99.18; Evidence=; Membrane ; Peripheral membrane protein Mitochondrion inner membrane ; Peripheral membrane protein Belongs to the universal ribosomal protein uS3 family. RNA polymerase II regulatory region sequence-specific DNA binding DNA binding damaged DNA binding RNA binding mRNA binding structural constituent of ribosome DNA-(apurinic or apyrimidinic site) lyase activity endodeoxyribonuclease activity nucleus nucleolus cytoplasm mitochondrial inner membrane mitochondrial matrix endoplasmic reticulum cytosol ribosome polysome plasma membrane DNA metabolic process translation cellular response to DNA damage stimulus response to oxidative stress chromosome segregation microtubule binding transcription factor binding positive regulation of gene expression postsynaptic density tubulin binding small ribosomal subunit negative regulation of translation enzyme binding kinase binding protein kinase binding cytosolic small ribosomal subunit Hsp70 protein binding positive regulation of microtubule polymerization positive regulation of protein complex assembly negative regulation of protein ubiquitination positive regulation of endodeoxyribonuclease activity oxidized purine DNA binding oxidized pyrimidine DNA binding ruffle membrane positive regulation of interleukin-2 production positive regulation of activated T cell proliferation DNA damage response, detection of DNA damage regulation of apoptotic process positive regulation of JUN kinase activity ubiquitin-like protein conjugating enzyme binding macromolecular complex binding negative regulation of DNA repair positive regulation of DNA repair positive regulation of T cell receptor signaling pathway protein kinase A binding positive regulation of NF-kappaB transcription factor activity spindle assembly Hsp90 protein binding response to TNF agonist small ribosomal subunit rRNA binding cellular response to hydrogen peroxide NF-kappaB complex cellular response to tumor necrosis factor mitotic spindle supercoiled DNA binding positive regulation of NIK/NF-kappaB signaling positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of DNA N-glycosylase activity positive regulation of base-excision repair ribonucleoprotein complex positive regulation of apoptotic signaling pathway positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis uc009ilr.1 uc009ilr.2 uc009ilr.3 uc009ilr.4 
ENSMUST00000033001.6 Dgat2 ENSMUST00000033001.6 diacylglycerol O-acyltransferase 2 (from RefSeq NM_026384.3) DGAT2_MOUSE Dgat2 ENSMUST00000033001.1 ENSMUST00000033001.2 ENSMUST00000033001.3 ENSMUST00000033001.4 ENSMUST00000033001.5 NM_026384 Q9DCV3 uc009ile.1 uc009ile.2 uc009ile.3 Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Reaction=a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA; Xref=Rhea:RHEA:10868, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64615; EC=2.3.1.20; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10869; Evidence=; Reaction=all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA; Xref=Rhea:RHEA:11488, ChEBI:CHEBI:17336, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:63410; EC=2.3.1.76; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11489; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2- di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA; Xref=Rhea:RHEA:38163, ChEBI:CHEBI:52333, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75583; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38164; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219, ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38220; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38435, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75735; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38436; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38439, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75824; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38440; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1- hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA; Xref=Rhea:RHEA:38071, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:73990, ChEBI:CHEBI:75466; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38072; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di- (9Z-octadecenoyl)-sn-glycerol + CoA; Xref=Rhea:RHEA:37911, ChEBI:CHEBI:52333, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:73990; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37912; Evidence=; Reaction=all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA; Xref=Rhea:RHEA:38175, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38176; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O- (9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:55340, ChEBI:CHEBI:34116, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:197429; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55341; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:37915, ChEBI:CHEBI:52323, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37916; Evidence=; Inhibited by niacin. Glycerolipid metabolism; triacylglycerol biosynthesis. Forms multimeric complexes consisting of several DGAT2 subunits (PubMed:21680734). Interacts with SLC27A1 and this interaction is enhanced in the presence of ZFYVE1 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Lipid droplet Cytoplasm, perinuclear region Predominantly expressed in liver. Also expressed in testis. In white adipose tissue, it is regulated by leptin. By insulin. Up-regulated in diabetic mice. Down-regulated upon fasting and replenished upon refeeding in adipose tissue and liver. Down-regulation in obese animals can reduce hepatic lipogenesis and hepatic steatosis as well as attenuate hyperlipidemia, thereby leading to an improvement in metabolic syndrome. Mice are lipopenic and die soon after birth, apparently from profound reductions in substrates for energy metabolism and from impaired permeability barrier function in the skin. Belongs to the diacylglycerol acyltransferase family. 2-acylglycerol O-acyltransferase activity diacylglycerol O-acyltransferase activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane lipid particle glycerol metabolic process lipid metabolic process positive regulation of triglyceride biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups triglyceride biosynthetic process lipid storage integral component of endoplasmic reticulum membrane low-density lipoprotein particle clearance long-chain fatty-acyl-CoA metabolic process cellular triglyceride homeostasis retinol metabolic process cholesterol homeostasis protein homodimerization activity intracellular membrane-bounded organelle positive regulation of gluconeogenesis negative regulation of fatty acid oxidation diacylglycerol metabolic process perinuclear region of cytoplasm retinol O-fatty-acyltransferase activity regulation of lipoprotein metabolic process fatty acid homeostasis fat pad development cellular response to oleic acid regulation of cholesterol metabolic process regulation of plasma lipoprotein particle levels perinuclear endoplasmic reticulum membrane mitochondrion uc009ile.1 uc009ile.2 uc009ile.3 
ENSMUST00000033004.8 Il4ra ENSMUST00000033004.8 interleukin 4 receptor, alpha, transcript variant 2 (from RefSeq NM_001363983.1) ENSMUST00000033004.1 ENSMUST00000033004.2 ENSMUST00000033004.3 ENSMUST00000033004.4 ENSMUST00000033004.5 ENSMUST00000033004.6 ENSMUST00000033004.7 Il4ra NM_001363983 Q3U905 Q3U905_MOUSE uc009jqc.1 uc009jqc.2 uc009jqc.3 Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Membrane ; Single- pass type I membrane protein Belongs to the type I cytokine receptor family. Type 4 subfamily. production of molecular mediator involved in inflammatory response cytokine receptor activity membrane integral component of membrane cytokine-mediated signaling pathway receptor complex uc009jqc.1 uc009jqc.2 uc009jqc.3 
ENSMUST00000033006.15 Nsmce1 ENSMUST00000033006.15 NSE1 homolog, SMC5-SMC6 complex component, transcript variant 1 (from RefSeq NM_026330.4) ENSMUST00000033006.1 ENSMUST00000033006.10 ENSMUST00000033006.11 ENSMUST00000033006.12 ENSMUST00000033006.13 ENSMUST00000033006.14 ENSMUST00000033006.2 ENSMUST00000033006.3 ENSMUST00000033006.4 ENSMUST00000033006.5 ENSMUST00000033006.6 ENSMUST00000033006.7 ENSMUST00000033006.8 ENSMUST00000033006.9 NM_026330 NSE1_MOUSE Q3TLN4 Q8K2B4 Q9CY20 Q9D720 uc009jqa.1 uc009jqa.2 uc009jqa.3 uc009jqa.4 uc009jqa.5 RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5-SMC6 heterodimer. Interacts with NSMCE3. Nucleus Chromosome, telomere Ubiquitinated. Belongs to the NSE1 family. Sequence=AAH31848.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH49558.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB27329.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE38758.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; double-strand break repair via homologous recombination chromosome, telomeric region ubiquitin-protein transferase activity nucleus nucleoplasm chromosome DNA repair postreplication repair DNA recombination cellular response to DNA damage stimulus protein ubiquitination transferase activity Smc5-Smc6 complex intracellular signal transduction intracellular membrane-bounded organelle metal ion binding protein dimerization activity positive regulation of response to DNA damage stimulus uc009jqa.1 uc009jqa.2 uc009jqa.3 uc009jqa.4 uc009jqa.5 
ENSMUST00000033008.10 Psma1 ENSMUST00000033008.10 proteasome subunit alpha 1 (from RefSeq NM_011965.2) ENSMUST00000033008.1 ENSMUST00000033008.2 ENSMUST00000033008.3 ENSMUST00000033008.4 ENSMUST00000033008.5 ENSMUST00000033008.6 ENSMUST00000033008.7 ENSMUST00000033008.8 ENSMUST00000033008.9 NM_011965 PSA1_MOUSE Q9R1P4 uc009jhy.1 uc009jhy.2 uc009jhy.3 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:16857966). Interacts with NOTCH3 (By similarity). Interacts with ZFAND1 (By similarity). Q9R1P4; Q91X58: Zfand2b; NbExp=2; IntAct=EBI-991653, EBI-15701753; Q9R1P4; Q9UM47: NOTCH3; Xeno; NbExp=2; IntAct=EBI-991653, EBI-1236377; Cytoplasm Nucleus Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. Detected in liver (at protein level). Up-regulated in liver tumor tissues. Up-regulated by the antioxidant dithiolethione (D3T) in liver, lung and colon (at the protein level). C-terminal extension is partially cleaved off by limited proteolysis leading to a conversion of the proteasome from its latent into its active form. Belongs to the peptidase T1A family. proteasome complex lipopolysaccharide binding immune system process negative regulation of inflammatory response to antigenic stimulus endopeptidase activity threonine-type endopeptidase activity protein binding nucleus nucleoplasm cytoplasm centrosome cytosol proteasome core complex proteolysis ubiquitin-dependent protein catabolic process peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, alpha-subunit complex proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process uc009jhy.1 uc009jhy.2 uc009jhy.3 
ENSMUST00000033009.16 Thap12 ENSMUST00000033009.16 THAP domain containing 12, transcript variant 1 (from RefSeq NM_028410.2) ENSMUST00000033009.1 ENSMUST00000033009.10 ENSMUST00000033009.11 ENSMUST00000033009.12 ENSMUST00000033009.13 ENSMUST00000033009.14 ENSMUST00000033009.15 ENSMUST00000033009.2 ENSMUST00000033009.3 ENSMUST00000033009.4 ENSMUST00000033009.5 ENSMUST00000033009.6 ENSMUST00000033009.7 ENSMUST00000033009.8 ENSMUST00000033009.9 NM_028410 P52K_MOUSE Prkrir Q80Y58 Q9CUX1 Thap0 Thap12 uc009ikt.1 uc009ikt.2 uc009ikt.3 uc009ikt.4 Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. Interacts with DNAJC3, probably sequestring it. nucleic acid binding DNA binding nucleus biological_process metal ion binding protein dimerization activity uc009ikt.1 uc009ikt.2 uc009ikt.3 uc009ikt.4 
ENSMUST00000033010.9 Kdm8 ENSMUST00000033010.9 lysine (K)-specific demethylase 8 (from RefSeq NM_029842.5) ENSMUST00000033010.1 ENSMUST00000033010.2 ENSMUST00000033010.3 ENSMUST00000033010.4 ENSMUST00000033010.5 ENSMUST00000033010.6 ENSMUST00000033010.7 ENSMUST00000033010.8 Jmjd5 KDM8_MOUSE Kdm8 NM_029842 Q9CXT6 uc009jpz.1 uc009jpz.2 uc009jpz.3 uc009jpz.4 uc009jpz.5 Bifunctional enzyme that acts both as an endopeptidase and 2- oxoglutarate-dependent monooxygenase. Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation. Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity. Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage. Additionally, acts as a Fe(2+) and 2- oxoglutarate-dependent monooxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established. Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation. Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition. Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation. Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (By similarity). Regulates the circadian gene expression in the liver (PubMed:30500822). Represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a catalytically-independent manner (By similarity). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (PubMed:30500822). Reaction=2-oxoglutarate + L-arginyl-[protein] + O2 = (3R)-3-hydroxy-L- arginyl-[protein] + CO2 + succinate; Xref=Rhea:RHEA:56744, Rhea:RHEA- COMP:10532, Rhea:RHEA-COMP:14712, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29965, ChEBI:CHEBI:30031, ChEBI:CHEBI:78294; EC=1.14.11.73; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Can form homodimers (via JmjC domain). Found in a complex with RCCD1. Interacts (via N-terminus) with RCCD1 (via N-terminus); this interaction stimulates H3K36me3 and H3K36me2 demethylation. Interacts (via JmjC domain) with H3C1 (By similarity). Interacts with FBXL3 and PSMD2 (PubMed:30500822). Interacts with CRY1 in a FBXL3-dependent manner (PubMed:30500822). Nucleus Chromosome Note=Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3). Expressed in a circadian manner in the liver. Conditional knockout in liver leads to disruption of circadian gene expression in the liver. The demethylase activity of JMJD5 is controversial. Demethylase activity towards H3K36me2 was observed in vivo and in vitro. In addition, demethylase activity towards H3K36me3 when in a complex with RCCD1 has been observed. In contrast, in other studies, JMJD5 was shown not to display any demethylase activity toward methylated H3K36 nor toward other methyllysines in the N-terminal tails of H3 and H4 in vitro. G2/M transition of mitotic cell cycle molecular_function chromatin binding endopeptidase activity aminopeptidase activity protein binding cellular_component nucleus nucleoplasm chromosome cytosol chromatin organization proteolysis cell cycle biological_process peptidase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors hydrolase activity protein destabilization circadian regulation of gene expression methylated histone binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated metal ion binding rhythmic process dioxygenase activity histone demethylase activity (H3-K36 specific) oxidation-reduction process histone H3-K36 demethylation uc009jpz.1 uc009jpz.2 uc009jpz.3 uc009jpz.4 uc009jpz.5 
ENSMUST00000033012.9 Copb1 ENSMUST00000033012.9 coatomer protein complex, subunit beta 1 (from RefSeq NM_033370.3) COPB_MOUSE Copb ENSMUST00000033012.1 ENSMUST00000033012.2 ENSMUST00000033012.3 ENSMUST00000033012.4 ENSMUST00000033012.5 ENSMUST00000033012.6 ENSMUST00000033012.7 ENSMUST00000033012.8 NM_033370 Q3T9Y4 Q3TT72 Q3U8G9 Q3UE02 Q9JIF7 uc009jhx.1 uc009jhx.2 uc009jhx.3 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1 (By similarity). Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins in cortical neurons. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis. Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits (By similarity). Interacts with CAPN8. Interacts with SCYL1 and PRKCE (By similarity). Interacts with COPG1 (By similarity). Interacts with ARF1 (myristoylated); this interaction is required for binding of COPB1 to Golgi membranes (By similarity). Interacts (via trunk domain) with ARF1 (via switch I region); the interaction is direct (By similarity). Interacts with KCNK2 (via N-terminus); this interaction increases the channel-mediated whole cell currents and promotes plasma membrane expression of KCNK2 (By similarity). Interacts with STX17 (By similarity). Interacts with TMEM115 (By similarity). Interacts with TMEM41B (By similarity). Cytoplasm Golgi apparatus membrane eripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane Endoplasmic reticulum-Golgi intermediate compartment Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Proteolytic cleavage by CAPN8 triggers translocation from Golgi to cytoplasm (PubMed:16476741). Found in perinuclear vesicular- tubular clusters (VTCs) and in the Golgi region where associated with vesicles, buds and rims of the Golgi stack (By similarity). Occasionally present at the trans-side of Golgi, but mainly present at the cis- Golgi side in transitional areas (TA), on so-called peripheral elements (PE) consisting of tubules and vesicles located between the cup-shaped transitional elements (TE) of the rough endoplasmic reticulum (RER) and the cis-most Golgi cisternae (By similarity). Present in cytoplasm, not associated with visible coats or membranes, with a minor fraction present on small clusters of tubules and vesicles (By similarity). Some association with high-density and low-density microsomes and mitochondria/nuclei fraction (By similarity). Very little found in plasma membrane fraction (By similarity). Predominantly expressed in the upper one-third of the oxyntic mucosa and in most regions of the pyloric mucosa (PubMed:16476741). Ubiquitously expressed including platelet, liver, heart, spleen, lung and kidney (PubMed:11441537). Proteolytically cleaved between Ser-528 and Ser-529 by CAPN8. Brefeldin A induces dissociation from the Golgi of the beta-COP and presumably the other coatomer subunits. Golgi membrane structural molecule activity cytoplasm endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus Golgi-associated vesicle cytosol plasma membrane intracellular protein transport ER to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport protein transport membrane vesicle-mediated transport membrane coat COPI vesicle coat COPI-coated vesicle COPI-coated vesicle membrane cytoplasmic vesicle intracellular membrane-bounded organelle uc009jhx.1 uc009jhx.2 uc009jhx.3 
ENSMUST00000033015.8 Il4i1 ENSMUST00000033015.8 interleukin 4 induced 1 (from RefSeq NM_010215.3) A0A0R4J0C2 A0A0R4J0C2_MOUSE ENSMUST00000033015.1 ENSMUST00000033015.2 ENSMUST00000033015.3 ENSMUST00000033015.4 ENSMUST00000033015.5 ENSMUST00000033015.6 ENSMUST00000033015.7 Il4i1 NM_010215 uc009gqy.1 uc009gqy.2 uc009gqy.3 uc009gqy.4 Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Belongs to the flavin monoamine oxidase family. oxidoreductase activity oxidation-reduction process uc009gqy.1 uc009gqy.2 uc009gqy.3 uc009gqy.4 
ENSMUST00000033018.15 Far1 ENSMUST00000033018.15 fatty acyl CoA reductase 1, transcript variant 1 (from RefSeq NM_027379.4) ENSMUST00000033018.1 ENSMUST00000033018.10 ENSMUST00000033018.11 ENSMUST00000033018.12 ENSMUST00000033018.13 ENSMUST00000033018.14 ENSMUST00000033018.2 ENSMUST00000033018.3 ENSMUST00000033018.4 ENSMUST00000033018.5 ENSMUST00000033018.6 ENSMUST00000033018.7 ENSMUST00000033018.8 ENSMUST00000033018.9 FACR1_MOUSE Far1 NM_027379 Q8BZS2 Q922J9 Q9CXE8 Q9D0Q1 Q9DAU2 uc009jho.1 uc009jho.2 uc009jho.3 uc009jho.4 Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:15220349). It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (By similarity). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (PubMed:15220349). Reaction=a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+); Xref=Rhea:RHEA:52716, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:77396, ChEBI:CHEBI:83139; EC=1.2.1.84; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52717; Evidence=; Reaction=2 H(+) + hexadecanoyl-CoA + 2 NADPH = CoA + hexadecan-1-ol + 2 NADP(+); Xref=Rhea:RHEA:36315, ChEBI:CHEBI:15378, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.2.1.84; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36316; Evidence=; Reaction=2 H(+) + 2 NADPH + octadecanoyl-CoA = CoA + 2 NADP(+) + octadecan-1-ol; Xref=Rhea:RHEA:36319, ChEBI:CHEBI:15378, ChEBI:CHEBI:32154, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.2.1.84; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36320; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH = (9Z)-octadecen-1-ol + CoA + 2 NADP(+); Xref=Rhea:RHEA:36323, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:73504; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36324; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH = (9Z,12Z)- octadecadien-1-ol + CoA + 2 NADP(+); Xref=Rhea:RHEA:36363, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:73534; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36364; Evidence=; pH dependence: Optimum pH is 7.4. ; Interacts with PEX19; PEX19 mediates the targeting of FAR1 to peroxisomes. Peroxisome membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q922J9-1; Sequence=Displayed; Name=2; IsoId=Q922J9-2; Sequence=VSP_021678, VSP_021679; Name=3; IsoId=Q922J9-3; Sequence=VSP_021680; Name=4; IsoId=Q922J9-4; Sequence=VSP_021681; Widely expressed. Expressed in all tissues examined. Highest expression seen in preputial gland. Expressed in the brain where large quantities of ether lipids are synthesized. Belongs to the fatty acyl-CoA reductase family. peroxisome peroxisomal membrane integral component of peroxisomal membrane lipid metabolic process ether lipid biosynthetic process wax biosynthetic process membrane integral component of membrane oxidoreductase activity long-chain fatty-acyl-CoA metabolic process glycerophospholipid biosynthetic process oxidation-reduction process fatty-acyl-CoA reductase (alcohol-forming) activity uc009jho.1 uc009jho.2 uc009jho.3 uc009jho.4 
ENSMUST00000033020.14 Acer3 ENSMUST00000033020.14 alkaline ceramidase 3, transcript variant 1 (from RefSeq NM_025408.3) ACER3_MOUSE Aphc ENSMUST00000033020.1 ENSMUST00000033020.10 ENSMUST00000033020.11 ENSMUST00000033020.12 ENSMUST00000033020.13 ENSMUST00000033020.2 ENSMUST00000033020.3 ENSMUST00000033020.4 ENSMUST00000033020.5 ENSMUST00000033020.6 ENSMUST00000033020.7 ENSMUST00000033020.8 ENSMUST00000033020.9 NM_025408 Phca Q542R2 Q9D099 Q9D0X4 Q9D3J4 uc009ikg.1 uc009ikg.2 uc009ikg.3 Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4- ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:26474409). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:26474409). Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1- phosphate in plasma (By similarity). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (PubMed:26474409). By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (PubMed:26938296). Reaction=an N-acyl-(4R)-4-hydroxysphinganine + H2O = (4R)- hydroxysphinganine + a fatty acid; Xref=Rhea:RHEA:33555, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868, ChEBI:CHEBI:31998, ChEBI:CHEBI:64124; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33556; Evidence=; Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine; Xref=Rhea:RHEA:45348, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:57756, ChEBI:CHEBI:85198; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45349; Evidence=; Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine; Xref=Rhea:RHEA:45376, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:57817, ChEBI:CHEBI:85206; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45377; Evidence=; Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)- hydroxysphinganine = (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)- eicosatetraenoate; Xref=Rhea:RHEA:45380, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:64124, ChEBI:CHEBI:85207; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45381; Evidence=; Reaction=H2O + N-(11Z-eicosenoyl)-sphing-4-enine = (11Z)-eicosenoate + sphing-4-enine; Xref=Rhea:RHEA:45356, ChEBI:CHEBI:15377, ChEBI:CHEBI:32426, ChEBI:CHEBI:57756, ChEBI:CHEBI:85284; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45357; Evidence=; Reaction=H2O + N-(11Z-eicosenoyl)-sphinganine = (11Z)-eicosenoate + sphinganine; Xref=Rhea:RHEA:45360, ChEBI:CHEBI:15377, ChEBI:CHEBI:32426, ChEBI:CHEBI:57817, ChEBI:CHEBI:85285; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45361; Evidence=; Reaction=H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine = (11Z)- eicosenoate + (4R)-hydroxysphinganine; Xref=Rhea:RHEA:45364, ChEBI:CHEBI:15377, ChEBI:CHEBI:32426, ChEBI:CHEBI:64124, ChEBI:CHEBI:85286; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45365; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-sphing-4-enine = (9Z)-octadecenoate + sphing-4-enine; Xref=Rhea:RHEA:41299, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57756, ChEBI:CHEBI:77996; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41300; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-sphinganine = (9Z)-octadecenoate + sphinganine; Xref=Rhea:RHEA:45372, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57817, ChEBI:CHEBI:74100; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45373; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine = (4R)- hydroxysphinganine + (9Z)-octadecenoate; Xref=Rhea:RHEA:45368, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:64124, ChEBI:CHEBI:85204; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45369; Evidence=; Reaction=an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine; Xref=Rhea:RHEA:20856, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868, ChEBI:CHEBI:52639, ChEBI:CHEBI:57756; EC=3.5.1.23; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20857; Evidence=; Reaction=an N-acylsphinganine + H2O = a fatty acid + sphinganine; Xref=Rhea:RHEA:33551, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868, ChEBI:CHEBI:31488, ChEBI:CHEBI:57817; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33552; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Activated by Ca(2+) and inhibited by Zn(2+). Lipid metabolism; sphingolipid metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Up-regulated with age in cerebeLlum and cerebrum. Down-regulated in immune cells and colonic epithelial cells by lipopolysaccharides/LPS. Homozygous knockout mice are viable and do not display overt phenotype with regard to fertility, body weight and anatomy (PubMed:26474409). They exhibit a decrease in ceramidase activity in brain, liver and lung tissues leading to the age-dependent accumulation of unsaturated long-chain C18:1-ceramides and the concomitant decrease in sphingosine and sphingosine-1-phosphate (PubMed:26474409). This is associated with a premature degeneration of Purkinje cells and age-dependent defects in motor coordination, skilled hindlimb function and balance capabilities (PubMed:26474409). Knockout mice also display exacerbated systemic inflammatory response (PubMed:26938296). Belongs to the alkaline ceramidase family. Golgi membrane calcium ion binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus lipid metabolic process sphingolipid metabolic process ceramide metabolic process inflammatory response zinc ion binding positive regulation of cell proliferation membrane integral component of membrane hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ceramidase activity integral component of Golgi membrane integral component of endoplasmic reticulum membrane myelination regulation of programmed cell death sphingosine biosynthetic process ceramide catabolic process metal ion binding phytoceramidase activity phytosphingosine biosynthetic process dihydroceramidase activity uc009ikg.1 uc009ikg.2 uc009ikg.3 
ENSMUST00000033025.7 Lcmt1 ENSMUST00000033025.7 leucine carboxyl methyltransferase 1, transcript variant 1 (from RefSeq NM_025304.3) A2RTH5 A2RTH5_MOUSE ENSMUST00000033025.1 ENSMUST00000033025.2 ENSMUST00000033025.3 ENSMUST00000033025.4 ENSMUST00000033025.5 ENSMUST00000033025.6 Lcmt1 NM_025304 uc009jpp.1 uc009jpp.2 Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues. Reaction=[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L- methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48544, Rhea:RHEA- COMP:12134, Rhea:RHEA-COMP:12135, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90516, ChEBI:CHEBI:90517; EC=2.1.1.233; Evidence= Belongs to the methyltransferase superfamily. LCMT family. protein C-terminal carboxyl O-methyltransferase activity cytosol protein methylation C-terminal protein methylation methyltransferase activity protein methyltransferase activity regulation of glucose metabolic process transferase activity protein C-terminal leucine carboxyl O-methyltransferase activity negative regulation of protein complex assembly methylation regulation of apoptotic process regulation of mitotic cell cycle spindle assembly checkpoint uc009jpp.1 uc009jpp.2 
ENSMUST00000033035.13 Slc5a11 ENSMUST00000033035.13 solute carrier family 5 (sodium/glucose cotransporter), member 11 (from RefSeq NM_146198.2) ENSMUST00000033035.1 ENSMUST00000033035.10 ENSMUST00000033035.11 ENSMUST00000033035.12 ENSMUST00000033035.2 ENSMUST00000033035.3 ENSMUST00000033035.4 ENSMUST00000033035.5 ENSMUST00000033035.6 ENSMUST00000033035.7 ENSMUST00000033035.8 ENSMUST00000033035.9 Kst1 NM_146198 Q6EZ51 Q8K0E3 SC5AB_MOUSE Slc5a11 Smit2 uc009jph.1 uc009jph.2 uc009jph.3 Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Can also transport D- chiro-inositol (DCI) but not L-fucose (By similarity). Exhibits stereospecific cotransport of both D-glucose and D-xylose (By similarity). May induce apoptosis through the TNF-alpha, PDCD1 pathway (By similarity). May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity). Reaction=myo-inositol(out) + 2 Na(+)(out) = myo-inositol(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72987, ChEBI:CHEBI:17268, ChEBI:CHEBI:29101; Evidence=; Reaction=1D-chiro-inositol(out) + 2 Na(+)(out) = 1D-chiro-inositol(in) + 2 Na(+)(in); Xref=Rhea:RHEA:73315, ChEBI:CHEBI:27372, ChEBI:CHEBI:29101; Evidence=; Reaction=D-glucose(out) + 2 Na(+)(out) = D-glucose(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70495, ChEBI:CHEBI:4167, ChEBI:CHEBI:29101; Evidence=; Reaction=D-xylose(out) + 2 Na(+)(out) = D-xylose(in) + 2 Na(+)(in); Xref=Rhea:RHEA:73367, ChEBI:CHEBI:29101, ChEBI:CHEBI:53455; Evidence=; MI transport activity inhibited by D-chiro- inositol (DCI), phlorizin (Pz) and sodium (Na(+)) (By similarity). Insulin increases D-chiro-inositol uptake (By similarity). Membrane ; Multi- pass membrane protein Apical cell membrane ; Multi-pass membrane protein Note=Located on apical membrane of enterocytes (By similarity). Located on membrane of kidney brush border membrane vesicles (BBMVs) and apical membrane of proximal convoluted tubules (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8K0E3-1; Sequence=Displayed; Name=2 ; IsoId=Q8K0E3-2; Sequence=VSP_052788; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. Sequence=AAQ08402.1; Type=Frameshift; Evidence=; glucose:sodium symporter activity plasma membrane ion transport sodium ion transport apoptotic process carbohydrate transport symporter activity membrane integral component of membrane transmembrane transporter activity transmembrane transport glucose transmembrane transport uc009jph.1 uc009jph.2 uc009jph.3 
ENSMUST00000033036.7 Dkk3 ENSMUST00000033036.7 dickkopf WNT signaling pathway inhibitor 3, transcript variant 2 (from RefSeq NM_015814.3) DKK3_MOUSE ENSMUST00000033036.1 ENSMUST00000033036.2 ENSMUST00000033036.3 ENSMUST00000033036.4 ENSMUST00000033036.5 ENSMUST00000033036.6 NM_015814 Q9QUN9 uc009jgj.1 uc009jgj.2 uc009jgj.3 Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). Interacts with LRP5 and LRP6. Secreted. Highest expression in brain, eye and heart. Expressed in the developing cochlea. The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6. Belongs to the dickkopf family. extracellular region extracellular space multicellular organism development Wnt signaling pathway negative regulation of Wnt signaling pathway negative regulation of aldosterone biosynthetic process co-receptor binding negative regulation of transcription, DNA-templated receptor antagonist activity negative regulation of canonical Wnt signaling pathway negative regulation of cortisol biosynthetic process negative regulation of receptor activity uc009jgj.1 uc009jgj.2 uc009jgj.3 
ENSMUST00000033044.16 Rusf1 ENSMUST00000033044.16 RUS family member 1, transcript variant 1 (from RefSeq NM_145590.2) A0A0R4J0B5 A0A0R4J0B5_MOUSE ENSMUST00000033044.1 ENSMUST00000033044.10 ENSMUST00000033044.11 ENSMUST00000033044.12 ENSMUST00000033044.13 ENSMUST00000033044.14 ENSMUST00000033044.15 ENSMUST00000033044.2 ENSMUST00000033044.3 ENSMUST00000033044.4 ENSMUST00000033044.5 ENSMUST00000033044.6 ENSMUST00000033044.7 ENSMUST00000033044.8 ENSMUST00000033044.9 NM_145590 Rusf1 uc009jyv.1 uc009jyv.2 uc009jyv.3 uc009jyv.4 Belongs to the RUS1 family. uc009jyv.1 uc009jyv.2 uc009jyv.3 uc009jyv.4 
ENSMUST00000033049.9 Cox6a2 ENSMUST00000033049.9 cytochrome c oxidase subunit 6A2 (from RefSeq NM_009943.2) CX6A2_MOUSE ENSMUST00000033049.1 ENSMUST00000033049.2 ENSMUST00000033049.3 ENSMUST00000033049.4 ENSMUST00000033049.5 ENSMUST00000033049.6 ENSMUST00000033049.7 ENSMUST00000033049.8 NM_009943 P43023 uc009jyi.1 uc009jyi.2 uc009jyi.3 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in the assembly and stabilization of complex IV (PubMed:31155743). Energy metabolism; oxidative phosphorylation. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Mitochondrion inner membrane ; Single-pass membrane protein Knockout mice show significant decline of COX activity and assembly in skeletal muscle. In particular, complexes IV, IV(2) and III(2)IV(2), and supercomplex I(1)III(2)IV(1) are reduced, whereas levels of complexes I, II, and III are normal. Belongs to the cytochrome c oxidase subunit 6A family. cytochrome-c oxidase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex IV mitochondrial electron transport, cytochrome c to oxygen aerobic respiration membrane enzyme regulator activity regulation of catalytic activity hydrogen ion transmembrane transport uc009jyi.1 uc009jyi.2 uc009jyi.3 
ENSMUST00000033050.5 Lyve1 ENSMUST00000033050.5 lymphatic vessel endothelial hyaluronan receptor 1 (from RefSeq NM_053247.4) Crsbp1 ENSMUST00000033050.1 ENSMUST00000033050.2 ENSMUST00000033050.3 ENSMUST00000033050.4 LYVE1_MOUSE NM_053247 Q3TUC1 Q8BHC0 Q99NE4 Xlkd1 uc009jfr.1 uc009jfr.2 uc009jfr.3 Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10187853). Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (By similarity). Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN. Membrane ; Single- pass type I membrane protein Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. Abundantly expressed in mesenteric lymphatic vessels at 16.5 dpc, with expression decreasing at 18.5 dpc (at protein level) (PubMed:28179430). Expressed in dermal lymphatic endothelial cells at 16.5 and 18.5 dpc (at protein level) (PubMed:28179430). O-glycosylated. transmembrane signaling receptor activity hyaluronic acid binding plasma membrane glycosaminoglycan catabolic process cell adhesion membrane integral component of membrane cell periphery uc009jfr.1 uc009jfr.2 uc009jfr.3 
ENSMUST00000033053.8 Itgax ENSMUST00000033053.8 integrin alpha X, transcript variant 1 (from RefSeq NM_021334.3) ENSMUST00000033053.1 ENSMUST00000033053.2 ENSMUST00000033053.3 ENSMUST00000033053.4 ENSMUST00000033053.5 ENSMUST00000033053.6 ENSMUST00000033053.7 ITAX_MOUSE NM_021334 Q9QXH4 uc009jyc.1 uc009jyc.2 uc009jyc.3 Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis (By similarity). Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2 (By similarity). Membrane ; Single-pass type I membrane protein The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. Belongs to the integrin alpha chain family. cell adhesion integrin-mediated signaling pathway positive regulation of cell proliferation integrin complex external side of plasma membrane cell surface positive regulation of gene expression membrane integral component of membrane positive regulation of cell migration receptor tyrosine kinase binding positive regulation of myelination heterotypic cell-cell adhesion positive regulation of angiogenesis metal ion binding defense response to virus activated T cell proliferation uc009jyc.1 uc009jyc.2 uc009jyc.3 
ENSMUST00000033054.10 Adm ENSMUST00000033054.10 adrenomedullin (from RefSeq NM_009627.2) ADML_MOUSE ENSMUST00000033054.1 ENSMUST00000033054.2 ENSMUST00000033054.3 ENSMUST00000033054.4 ENSMUST00000033054.5 ENSMUST00000033054.6 ENSMUST00000033054.7 ENSMUST00000033054.8 ENSMUST00000033054.9 NM_009627 P97297 P97453 Q6GTK2 uc009jfj.1 uc009jfj.2 uc009jfj.3 AM and PAMP are potent hypotensive and vasodilatator agents. Secreted. Belongs to the adrenomedullin family. vasculogenesis response to hypoxia neural tube closure regulation of the force of heart contraction G-protein coupled receptor internalization regulation of systemic arterial blood pressure hormone activity extracellular region extracellular space cytoplasm adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration heart development female pregnancy aging androgen metabolic process positive regulation of cell proliferation negative regulation of cell proliferation response to cold response to wounding response to organic substance positive regulation of heart rate antibacterial humoral response cAMP-mediated signaling animal organ regeneration neuron projection regeneration receptor internalization adrenomedullin receptor binding response to lipopolysaccharide response to insulin regulation of urine volume odontogenesis of dentin-containing tooth response to starvation positive regulation of apoptotic process negative regulation of vascular permeability positive regulation of angiogenesis negative regulation of vasoconstriction hormone secretion developmental growth defense response to Gram-negative bacterium defense response to Gram-positive bacterium response to glucocorticoid calcium ion homeostasis branching involved in labyrinthine layer morphogenesis spongiotrophoblast layer development vascular smooth muscle cell development amylin receptor signaling pathway adrenomedullin receptor signaling pathway positive regulation of vasculogenesis uc009jfj.1 uc009jfj.2 uc009jfj.3 
ENSMUST00000033056.5 Pycard ENSMUST00000033056.5 PYD and CARD domain containing (from RefSeq NM_023258.4) ASC_MOUSE Asc ENSMUST00000033056.1 ENSMUST00000033056.2 ENSMUST00000033056.3 ENSMUST00000033056.4 NM_023258 Q9D2W9 Q9EPB4 uc009jxu.1 uc009jxu.2 uc009jxu.3 uc009jxu.4 Functions as a key mediator in apoptosis and inflammation (PubMed:32424362, PubMed:34678144). Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner (By similarity). Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3 (By similarity). Involved in innate immune response by acting as an integral adapter in the assembly of various inflammasomes (NLRP2, NLRP3, NLRP6 and AIM2) which recruit and activate caspase-1 leading to processing and secretion of pro-inflammatory cytokines (PubMed:32424362, PubMed:34678144, PubMed:15190255, PubMed:15507117, PubMed:21892172, PubMed:22555457). Caspase-1-dependent inflammation leads to macrophage pyroptosis, a form of cell death (By similarity). The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions (By similarity). Clustered PYCARD nucleates the formation of caspase-1 filaments through the interaction of their respective CARD domains, acting as a platform for of caspase-1 polymerization (By similarity). In the NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1 (By similarity). In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation (By similarity). May be involved in RIGI-triggered pro-inflammatory responses and inflammasome activation (By similarity). In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8 (PubMed:22555457). In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form (By similarity). Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways (By similarity). For regulation of NF-kappa-B activating and inhibiting functions have been reported (By similarity). Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK (By similarity). Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2- dependent NF-kappa-B activation and activating interleukin-1 beta processing (By similarity). Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating CGAS in presence of cytoplasmic double-stranded DNA (PubMed:28314590). Self-associates; enforced oligomerization induces apoptosis, NF-kappa-B regulation and interleukin-1 beta secretion (By similarity). Homooligomers can form disk-like particles of approximately 12 nm diameter and approximately 1 nm height (By similarity). Component of several inflammasomes containing one pattern recognition receptor/sensor, such as NLRP2, NLRP3, NLRP6, NLRC4, AIM2, MEFV or NOD2, and probably NLRC4 or NLRP12 (PubMed:32424362, PubMed:34678144). Major component of the ASC pyroptosome, a 1-2 um supramolecular assembly (one per macrophage cell) which consists of oligomerized PYCARD dimers and CASP1 (By similarity). Interacts with CASP1 (precursor form); the interaction induces activation of CASP1 leading to the processing of interleukin-1 beta; PYCARD competes with RIPK2 for binding to CASP1 (By similarity). Interacts with NLRP3; the interaction requires the homooligomerization of NLRP3 (PubMed:30487600). Interacts with NLRP2, NLRC4, MEFV, CARD16, AIM2, NOD2, RIGI, RIPK2, PYDC1, PYDC2, NLRP10, CHUK, IKBKB and BAX (By similarity). Interacts with CASP8 (PubMed:22555457). Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis) (PubMed:34471287). Q9EPB4; P29452: Casp1; NbExp=2; IntAct=EBI-6253348, EBI-489700; Q9EPB4; Q8R4B8: Nlrp3; NbExp=3; IntAct=EBI-6253348, EBI-6910832; Cytoplasm flammasome Endoplasmic reticulum Mitochondrion Nucleus Note=Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures. Upon NLRP3 inflammasome activation redistributes to the perinuclear space localizing to endoplasmic reticulum and mitochondria. Localized primarily to the nucleus in resting monocytes/macrophages and rapidly redistributed to the cytoplasm upon pathogen infection (By similarity). Localized to large cytoplasmic aggregate appearing as a speck containing AIM2, PYCARD, CASP8 and bacterial DNA after infection with Francisella tularensis (PubMed:22555457). Expressed in small intestine, colon, thymus, spleen, brain, heart, skeletal muscle, kidney, lung and liver. Strongly expressed at 9.5 dpc in the telencephalon, thalamic areas of the diencephalon, heart and liver. The CARD domain mediates interaction with CASP1 and NLRC4. The pyrin domain mediates homotypic interactions with pyrin domains of proteins such as of NLRP3, PYDC1, PYDC2 and AIM2. Phosphorylated. 'Lys-63'-linked polyubiquitination by TRAF3 is critical for speck formation and inflammasome activation. Increased resistance to endotoxic shock and severe defects in caspase-1 activation and interleukin-1 beta and interleukin-18 production in macrophages in response to several pro- inflammatory molecules (PubMed:15190255, PubMed:15507117). Mutants are resitant to vaccinia virus (VACV) but not vesicular somatitis virus (VSV) infection. They show lower viral loads in the lungs compared to wild type mice, they produce higher levels of type I IFN, IL6 and RSAD2/Viperin after VCAV INFECTION (PubMed:28314590). Golgi membrane myeloid dendritic cell activation protease binding activation of innate immune response positive regulation of defense response to virus by host myeloid dendritic cell activation involved in immune response immune system process positive regulation of antigen processing and presentation of peptide antigen via MHC class II positive regulation of adaptive immune response cysteine-type endopeptidase activity interleukin-6 receptor binding protein binding tropomyosin binding extracellular region nucleus nucleolus cytoplasm mitochondrion endoplasmic reticulum cytosol proteolysis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response IkappaB kinase complex response to bacterium regulation of autophagy regulation of tumor necrosis factor-mediated signaling pathway peptidase activator activity involved in apoptotic process myosin I binding enzyme binding positive regulation of actin filament polymerization regulation of protein stability negative regulation of NF-kappaB transcription factor activity Pyrin domain binding interleukin-1 beta production negative regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production macromolecular complex tumor necrosis factor-mediated signaling pathway positive regulation of activated T cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator identical protein binding protein homodimerization activity regulation of apoptotic process neuronal cell body positive regulation of apoptotic process regulation of GTPase activity negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process ion channel binding macropinocytosis innate immune response positive regulation of JNK cascade protein dimerization activity positive regulation of interleukin-1 beta secretion regulation of inflammatory response positive regulation of phagocytosis defense response to Gram-negative bacterium positive regulation of T cell activation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein homooligomerization defense response to virus positive regulation of ERK1 and ERK2 cascade BMP receptor binding cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor negative regulation of protein serine/threonine kinase activity intrinsic apoptotic signaling pathway by p53 class mediator NLRP1 inflammasome complex NLRP3 inflammasome complex positive regulation of chemokine secretion positive regulation of release of cytochrome c from mitochondria cysteine-type endopeptidase activity involved in apoptotic process AIM2 inflammasome complex extrinsic apoptotic signaling pathway in absence of ligand activation of cysteine-type endopeptidase activity negative regulation of cytokine production involved in inflammatory response positive regulation of T cell migration positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion positive regulation of cysteine-type endopeptidase activity positive regulation of interleukin-10 secretion positive regulation of extrinsic apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway uc009jxu.1 uc009jxu.2 uc009jxu.3 uc009jxu.4 
ENSMUST00000033057.9 Dkkl1 ENSMUST00000033057.9 dickkopf-like 1 (from RefSeq NM_015789.3) DKKL1_MOUSE Dkkl1 ENSMUST00000033057.1 ENSMUST00000033057.2 ENSMUST00000033057.3 ENSMUST00000033057.4 ENSMUST00000033057.5 ENSMUST00000033057.6 ENSMUST00000033057.7 ENSMUST00000033057.8 NM_015789 Q9EQT4 Q9ERW0 Q9ERW1 Q9QZL9 Sgy1 uc009guc.1 uc009guc.2 uc009guc.3 uc009guc.4 Involved in fertilization by facilitating sperm penetration of the zona pellucida (PubMed:19596312, PubMed:22817830). May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells (PubMed:18818293). Is not essential either for development or fertility (PubMed:19596310). Interacts with SLXL1; Co-localize in seminiferous tubules (PubMed:21698294). Interacts with SLY (PubMed:19176879). Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome Note=Localized specifically to the crescent shaped acrosome at the apex of the sperm head. Testis-specific. Abundant in the seminiferous tubules where it is associated with developing spermatocytes. Expressed only in testis (at protein level) (PubMed:15892050, PubMed:19596310). Not detectable on postnatal days 4 and 9 but after day 18 it gradually increased as the development of testes progressed. Expressed at high levels in testis and at weak levels in epididymis (PubMed:22817830). Expressed in the embryo only after day 15. In the adult, expressed only in developing spermatocytes. Expressed in the developing cochlea. Detected only in developing spermatocytes and spermatids in seminiferous tubules. Moreover, first appears specifically in zygotene/pachytene spermatocytes. Found in puddles in the pachytene spermatocytes of all stage tubules and then in crescent shaped structures characteristic of acrosomes in early step spermatids. Detected in mature sperm (PubMed:15892050). Expressed strongly in trophoblast stem cells and further up-regulated in trophoblast giant cells. Expression is maintained in post-implantation placental tissues in utero. Highly expressed from 7.5 dpc trophectoderm to 12.5 dpc placenta. Expression remains baseline in postimplantation embryonic tissues (PubMed:19596312). Contains a N-terminal domain similar to that of the N-terminal section of DKK3. N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm. Nullizygous embryos Dkkl1 mice develop into viable, fertile adults. acrosomal vesicle protein binding extracellular region extracellular space penetration of zona pellucida cytoplasmic vesicle co-receptor binding positive regulation of apoptotic process positive regulation of fat cell differentiation receptor antagonist activity negative regulation of canonical Wnt signaling pathway negative regulation of testosterone biosynthetic process negative regulation of receptor activity uc009guc.1 uc009guc.2 uc009guc.3 uc009guc.4 
ENSMUST00000033060.14 Tead2 ENSMUST00000033060.14 TEA domain family member 2, transcript variant 2 (from RefSeq NM_011565.3) ENSMUST00000033060.1 ENSMUST00000033060.10 ENSMUST00000033060.11 ENSMUST00000033060.12 ENSMUST00000033060.13 ENSMUST00000033060.2 ENSMUST00000033060.3 ENSMUST00000033060.4 ENSMUST00000033060.5 ENSMUST00000033060.6 ENSMUST00000033060.7 ENSMUST00000033060.8 ENSMUST00000033060.9 NM_011565 Q3UPV9 Q3UPV9_MOUSE Tead2 uc009gud.1 uc009gud.2 uc009gud.3 Nucleus transcription factor activity, transcription factor recruiting transcription coactivator binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated hippo signaling intracellular membrane-bounded organelle positive regulation of transcription, DNA-templated protein heterodimerization activity macromolecular complex assembly TEAD-2-YAP complex disordered domain specific binding uc009gud.1 uc009gud.2 uc009gud.3 
ENSMUST00000033070.9 Kat8 ENSMUST00000033070.9 K(lysine) acetyltransferase 8, transcript variant 1 (from RefSeq NM_026370.2) ENSMUST00000033070.1 ENSMUST00000033070.2 ENSMUST00000033070.3 ENSMUST00000033070.4 ENSMUST00000033070.5 ENSMUST00000033070.6 ENSMUST00000033070.7 ENSMUST00000033070.8 KAT8_MOUSE Mof Myst1 NM_026370 Q3UIY0 Q8BJ69 Q8BJ76 Q8CI73 Q9D1P2 uc009jxh.1 uc009jxh.2 uc009jxh.3 Histone acetyltransferase which may be involved in transcriptional activation (PubMed:31794431). May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (Probable). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120' (By similarity). Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45949; Evidence=; Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1 (By similarity). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (By similarity). Interacts with KANSL1; the interaction is direct (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Interacts with the chromodomain of MORF4L1/MRG15 (By similarity). Interacts with ATM (via its Tudor-knot domain) (By similarity). Interacts with MSL1; the interaction is direct (PubMed:21217699, PubMed:17335777). Interacts with MSL3 (By similarity). Interacts with NELFD (PubMed:17335777). Nucleus Chromosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D1P2-1; Sequence=Displayed; Name=2; IsoId=Q9D1P2-2; Sequence=VSP_014580, VSP_014581; Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function. Cerebrum-specific knockout of the gene resulted in impaired postnatal growth, hyperactive behavior, and early death. Analysis of mutant mice at various stages of embryonic development showed cerebral hypoplasia with defects in neocortical lamination, abnormal neuronal differentiation with decreased neuronal progenitor cells, and aberrant neuronal migration. These defects were associated with impaired cell proliferation, increased apoptosis, defective neurosphere formation in vitro, and decreased H4K16 propionylation and acetylation in the cerebrocortical neuroepithelium. Belongs to the MYST (SAS/MOZ) family. Sequence=BAC25539.1; Type=Frameshift; Evidence=; histone acetyltransferase complex kinetochore nuclear chromatin histone acetyltransferase activity protein binding nucleus nucleoplasm chromosome chromatin organization regulation of transcription, DNA-templated transcription factor binding regulation of autophagy nuclear matrix acetyltransferase activity histone acetylation transferase activity transferase activity, transferring acyl groups enzyme binding myeloid cell differentiation methylated histone binding histone binding histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding histone acetyltransferase activity (H4-K16 specific) MLL1 complex MSL complex uc009jxh.1 uc009jxh.2 uc009jxh.3 
ENSMUST00000033074.8 Vkorc1 ENSMUST00000033074.8 vitamin K epoxide reductase complex, subunit 1 (from RefSeq NM_178600.2) ENSMUST00000033074.1 ENSMUST00000033074.2 ENSMUST00000033074.3 ENSMUST00000033074.4 ENSMUST00000033074.5 ENSMUST00000033074.6 ENSMUST00000033074.7 NM_178600 Q9CRC0 VKOR1_MOUSE uc009jxe.1 uc009jxe.2 Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DV062359.1, BU558856.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. Reaction=[protein]-disulfide + H2O + phylloquinone = 2,3- epoxyphylloquinone + [protein]-dithiol; Xref=Rhea:RHEA:13817, Rhea:RHEA-COMP:10593, Rhea:RHEA-COMP:10594, ChEBI:CHEBI:15377, ChEBI:CHEBI:15759, ChEBI:CHEBI:18067, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058; EC=1.17.4.4; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:13819; Evidence=; Reaction=[protein]-disulfide + phylloquinol = [protein]-dithiol + phylloquinone; Xref=Rhea:RHEA:57744, Rhea:RHEA-COMP:10593, Rhea:RHEA- COMP:10594, ChEBI:CHEBI:18067, ChEBI:CHEBI:28433, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058; EC=1.17.4.4; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:57746; Evidence=; Inhibited by warfarin (coumadin) (PubMed:15879509). Warfarin locks VKORC1 in both redox states into the closed conformation (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Detected in liver. Partially oxidized VKORC1 forms a cysteine adduct with substrates, vitamin K 2,3-epoxide, inducing a closed conformation, juxtaposing all cysteines (S-S or SH) for unimpeded electron transfer. VKOR becomes fully oxidized with an open conformation that releases reaction products, vitamin K quinone, or hydroquinone. Cys-132 and Cys- 135 constitute the catalytic redox-active center. Cys-43 and Cys-51 are the cysteine pair that mediates transfer of reducing equivalents during catalysis. Mice are born at the expected Mendelian rate and appear normal, but die between one and twenty days after birth, due to severe bleeding. In about 75% of the cases, subdural bleeding is observed, in addition to intracerebral and intramuscular bleeding. Daily oral administration of vitamin K to the mutant mice leads to normal survival, but the mice die within seven days after the cessation of vitamin K administration. Besides, both homozygous and heterozygous mutant mice display defects in bone development with reduced length of the calcified part of the long bones in front and hind limbs. Belongs to the VKOR family. endoplasmic reticulum endoplasmic reticulum membrane blood coagulation response to organonitrogen compound response to organic cyclic compound membrane integral component of membrane oxidoreductase activity drug metabolic process peptidyl-glutamic acid carboxylation regulation of blood coagulation vitamin K biosynthetic process vitamin K metabolic process intracellular membrane-bounded organelle response to antibiotic vitamin-K-epoxide reductase (warfarin-sensitive) activity vitamin-K-epoxide reductase (warfarin-insensitive) activity quinone binding positive regulation of coagulation oxidation-reduction process bone development uc009jxe.1 uc009jxe.2 
ENSMUST00000033075.14 Stx4a ENSMUST00000033075.14 syntaxin 4A (placental), transcript variant 1 (from RefSeq NM_009294.4) ENSMUST00000033075.1 ENSMUST00000033075.10 ENSMUST00000033075.11 ENSMUST00000033075.12 ENSMUST00000033075.13 ENSMUST00000033075.2 ENSMUST00000033075.3 ENSMUST00000033075.4 ENSMUST00000033075.5 ENSMUST00000033075.6 ENSMUST00000033075.7 ENSMUST00000033075.8 ENSMUST00000033075.9 NM_009294 P70452 Q3TSL5 Q3UKQ8 Q80WT8 STX4_MOUSE Stx4 uc009jwy.1 uc009jwy.2 uc009jwy.3 uc009jwy.4 Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. Interacts with STXBP6. Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis (By similarity). Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2. Interacts with STXBP5L. P70452; Q155P7: Cenpf; NbExp=9; IntAct=EBI-645716, EBI-2211248; P70452; Q60770-1: Stxbp3; NbExp=3; IntAct=EBI-645716, EBI-15639434; P70452; P61765: Stxbp1; Xeno; NbExp=2; IntAct=EBI-645716, EBI-1029097; Cell membrane ; Single-pass type IV membrane protein Cell projection, neuron projection Note=Localizes to neurite tips in neuronal cells. Belongs to the syntaxin family. SNARE binding storage vacuole SNAP receptor activity protein binding extracellular space cytoplasm endosome trans-Golgi network plasma membrane neurotransmitter transport intracellular protein transport exocytosis vesicle fusion synaptic vesicle positive regulation of cell proliferation cell surface endomembrane system membrane integral component of membrane synaptic vesicle exocytosis synaptic vesicle docking vesicle-mediated transport sphingomyelin phosphodiesterase activator activity basolateral plasma membrane apical plasma membrane Rab GTPase binding regulation of exocytosis lamellipodium positive regulation of cell migration spectrin binding SNARE complex synaptic vesicle fusion to presynaptic active zone membrane response to hydroperoxide SNARE complex assembly myelin sheath adaxonal region positive regulation of insulin secretion involved in cellular response to glucose stimulus somatodendritic compartment sarcolemma specific granule presynaptic membrane positive regulation of catalytic activity dendritic spine lateral loop positive regulation of eosinophil degranulation synapse phagocytic vesicle positive regulation of cell adhesion vesicle docking organelle fusion perinuclear region of cytoplasm presynaptic active zone membrane positive regulation of chemotaxis positive regulation of immunoglobulin secretion long-term synaptic potentiation membrane fusion macromolecular complex assembly cellular response to interferon-gamma postsynapse exocytic insertion of neurotransmitter receptor to postsynaptic membrane glutamatergic synapse vesicle-mediated transport in synapse regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of protein localization to plasma membrane positive regulation of protein localization to cell surface uc009jwy.1 uc009jwy.2 uc009jwy.3 uc009jwy.4 
ENSMUST00000033086.8 Phkg2 ENSMUST00000033086.8 phosphorylase kinase, gamma 2 (testis), transcript variant 1 (from RefSeq NM_026888.3) A6H632 ENSMUST00000033086.1 ENSMUST00000033086.2 ENSMUST00000033086.3 ENSMUST00000033086.4 ENSMUST00000033086.5 ENSMUST00000033086.6 ENSMUST00000033086.7 NM_026888 PHKG2_MOUSE Q9DB30 uc009jwc.1 uc009jwc.2 uc009jwc.3 uc009jwc.4 Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity). Reaction=2 ATP + phosphorylase b = 2 ADP + phosphorylase a.; EC=2.7.11.19; Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity phosphorylase kinase activity calmodulin binding ATP binding cytosol phosphorylase kinase complex carbohydrate metabolic process glycogen metabolic process glycogen biosynthetic process protein phosphorylation kinase activity phosphorylation transferase activity enzyme binding uc009jwc.1 uc009jwc.2 uc009jwc.3 uc009jwc.4 
ENSMUST00000033093.10 Bax ENSMUST00000033093.10 BCL2-associated X protein, transcript variant 1 (from RefSeq NM_007527.4) Bax ENSMUST00000033093.1 ENSMUST00000033093.2 ENSMUST00000033093.3 ENSMUST00000033093.4 ENSMUST00000033093.5 ENSMUST00000033093.6 ENSMUST00000033093.7 ENSMUST00000033093.8 ENSMUST00000033093.9 NM_007527 Q544Z6 Q544Z6_MOUSE uc009gvi.1 uc009gvi.2 uc009gvi.3 Belongs to the Bcl-2 family. B cell apoptotic process release of cytochrome c from mitochondria nucleus nuclear envelope cytoplasm mitochondrion mitochondrial outer membrane mitochondrial permeability transition pore complex endoplasmic reticulum endoplasmic reticulum membrane cytosol apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrial fusion lipid binding activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c apoptotic mitochondrial changes response to toxic substance establishment or maintenance of transmembrane electrochemical gradient negative regulation of mitochondrial membrane potential channel activity membrane integral component of membrane negative regulation of protein binding positive regulation of protein oligomerization release of matrix enzymes from mitochondria identical protein binding protein homodimerization activity regulation of apoptotic process positive regulation of apoptotic process regulation of protein homodimerization activity regulation of protein heterodimerization activity positive regulation of neuron apoptotic process mitochondrial fragmentation involved in apoptotic process pore complex protein heterodimerization activity protein oligomerization protein homooligomerization BH3 domain binding regulation of mitochondrial membrane potential intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cell periphery positive regulation of release of cytochrome c from mitochondria Bcl-2 family protein complex BAX complex BAK complex apoptotic signaling pathway extrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway positive regulation of endoplasmic reticulum unfolded protein response positive regulation of apoptotic DNA fragmentation B cell receptor apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway uc009gvi.1 uc009gvi.2 uc009gvi.3 
ENSMUST00000033098.16 Bcat2 ENSMUST00000033098.16 branched chain aminotransferase 2, mitochondrial, transcript variant 1 (from RefSeq NM_009737.4) Bcat2 ENSMUST00000033098.1 ENSMUST00000033098.10 ENSMUST00000033098.11 ENSMUST00000033098.12 ENSMUST00000033098.13 ENSMUST00000033098.14 ENSMUST00000033098.15 ENSMUST00000033098.2 ENSMUST00000033098.3 ENSMUST00000033098.4 ENSMUST00000033098.5 ENSMUST00000033098.6 ENSMUST00000033098.7 ENSMUST00000033098.8 ENSMUST00000033098.9 NM_009737 Q3ULU3 Q3ULU3_MOUSE uc009gwd.1 uc009gwd.2 uc009gwd.3 uc009gwd.4 Reaction=2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate; Xref=Rhea:RHEA:24801, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:35146, ChEBI:CHEBI:58045; EC=2.6.1.42; Evidence= Reaction=2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L- glutamate; Xref=Rhea:RHEA:18321, ChEBI:CHEBI:16810, ChEBI:CHEBI:17865, ChEBI:CHEBI:29985, ChEBI:CHEBI:57427; EC=2.6.1.42; Evidence= Reaction=2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L- glutamate; Xref=Rhea:RHEA:24813, ChEBI:CHEBI:11851, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57762; EC=2.6.1.42; Evidence= Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence= Homodimer. Mitochondrion Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. catalytic activity branched-chain-amino-acid transaminase activity transaminase activity cellular amino acid biosynthetic process branched-chain amino acid metabolic process branched-chain amino acid biosynthetic process transferase activity L-leucine transaminase activity L-valine transaminase activity L-isoleucine transaminase activity uc009gwd.1 uc009gwd.2 uc009gwd.3 uc009gwd.4 
ENSMUST00000033099.6 Fgf21 ENSMUST00000033099.6 fibroblast growth factor 21 (from RefSeq NM_020013.4) ENSMUST00000033099.1 ENSMUST00000033099.2 ENSMUST00000033099.3 ENSMUST00000033099.4 ENSMUST00000033099.5 FGF21_MOUSE NM_020013 Q9JJN1 uc009gwe.1 uc009gwe.2 uc009gwe.3 Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity. Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4 (By similarity). Secreted Most abundantly expressed in the liver, also expressed in the thymus at lower levels (PubMed:10858549, PubMed:30389664). Expressed in skeletal muscle (at protein level). Secreted in plasma (at protein level) (PubMed:30605666). In the liver, down-regulated in postprandial conditions (PubMed:30389664). Up-regulated at the transcriptional level by CREB3L3 (PubMed:30389664). Belongs to the heparin-binding growth factors family. fibroblast growth factor receptor binding extracellular region extracellular space cytosol growth factor activity positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway positive regulation of triglyceride catabolic process response to activity endoplasmic reticulum unfolded protein response response to nutrient levels cellular response to drug positive regulation of glucose import positive regulation of ERK1 and ERK2 cascade cellular response to glucose stimulus cellular response to glucagon stimulus cellular response to low-density lipoprotein particle stimulus endothelial cell apoptotic process positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway negative regulation of neuron death response to methionine negative regulation of endothelial cell apoptotic process uc009gwe.1 uc009gwe.2 uc009gwe.3 
ENSMUST00000033100.5 Izumo1 ENSMUST00000033100.5 izumo sperm-egg fusion 1, transcript variant 4 (from RefSeq NM_001418986.1) ENSMUST00000033100.1 ENSMUST00000033100.2 ENSMUST00000033100.3 ENSMUST00000033100.4 IZUM1_MOUSE Izumo1 NM_001418986 Q9D9J7 uc009gwh.1 uc009gwh.2 uc009gwh.3 Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg (PubMed:15759005, PubMed:24739963, PubMed:27309808). The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:15759005, PubMed:24739963, PubMed:27309808). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed:15759005, PubMed:24739963, PubMed:27309808). Monomer, homodimer and homooligomer; depending on the context (PubMed:19658160, PubMed:26568141, PubMed:29954238). Interacts with IZUMO1R/JUNO (PubMed:25209248, PubMed:24739963, PubMed:27309808, PubMed:32484434). IZUMO1 and IZUMO1R/JUNO form a complex with 1:1 stoichiometry (By similarity). In gamete recognition, IZUMO1R/JUNO first binds to monomeric IZUMO1 (PubMed:26568141, PubMed:29954238). The weak, but specific interaction with IZUMO1R/JUNO induces IZUMO1 homodimerization (PubMed:26568141, PubMed:29954238). The process follows a tight binding phase where IZUMO1 bends the entire structure towards the sperm membrane side through a thiol-disulfide exchange reaction (PubMed:26568141, PubMed:29954238). The molecule no longer binds to IZUMO1R/JUNO and instead binds to a putative second oocyte receptor (PubMed:26568141, PubMed:29954238). Interacts with ACE3 (PubMed:20421979, PubMed:35960805, PubMed:19658160, PubMed:24739963, PubMed:25209248, PubMed:26568141, PubMed:27309808, PubMed:29954238) (By similarity). Part of a oolemmal binding multimeric complex (IZUMO1 complex) composed at least of IZUMO1 and GLIPR1L1; the complex assemblage is influenced by the maturation status of the male germ cell (PubMed:31672133). Interacts with GLIPR1L1 (PubMed:31672133). Interacts with FREY; the interaction retains IZUMO1 at the endoplasmic reticulum membrane and coordinates IZUMO1 complex assembly (PubMed:35960805). Cell membrane ingle-pass type I membrane protein Cytoplasmic vesicle, secretory vesicle, acrosome membrane ingle-pass type I membrane protein Note=Localizes initially to the acrosome membrane of the sperm head (both outer and inner acrosomal membranes). During the acrosome reaction, translocates to the plasma membrane. Sperm-specific (at protein level) (PubMed:15759005, PubMed:19658160, PubMed:20421979, PubMed:32484434, PubMed:35960805, PubMed:31672133). Detectable on sperm surface only after the acrosome reaction (PubMed:15759005). Partially colocalizes with FREY1 in endoplasmic reticulum membrane of round spermatids. The extracellular domain assumes a distinct boomerang shape when not bound to IZUMO1R/JUNO (By similarity). Interaction with IZUMO1R/JUNO triggers a conformation change, so that the IZUMO1 extracellular domain assumes an upright conformation (By similarity). The cytoplasmic C-terminus region is not essential for fertilization (PubMed:27624483). It is however required for protein stability (PubMed:27624483). N-glycosylated. Glycosylation is not essential for fusion and for proper protein trafficking in sperm. Phosphorylated (PubMed:19658160, PubMed:27624483). The cytoplasmic C-terminus is phosphorylated and undergoes phosphorylation changes during epididymal transit (PubMed:27624483). Mice are healthy but the males are sterile (PubMed:15759005). They produce morphologically normal sperm that can bind to and penetrate the zona pellucida but that are incapable of fusing with eggs (PubMed:15759005). Izumo is the name of a Japanese shrine to marriage. Belongs to the Izumo family. acrosomal vesicle acrosomal membrane receptor binding protein binding plasma membrane cell adhesion single fertilization fusion of sperm to egg plasma membrane membrane integral component of membrane cytoplasmic vesicle heterotypic cell-cell adhesion sperm-egg recognition identical protein binding protein homodimerization activity protein binding involved in heterotypic cell-cell adhesion uc009gwh.1 uc009gwh.2 uc009gwh.3 
ENSMUST00000033121.7 Nomo1 ENSMUST00000033121.7 nodal modulator 1 (from RefSeq NM_153057.4) ENSMUST00000033121.1 ENSMUST00000033121.2 ENSMUST00000033121.3 ENSMUST00000033121.4 ENSMUST00000033121.5 ENSMUST00000033121.6 NM_153057 NOMO1_MOUSE Nomo1 Q3TKZ1 Q6GQT9 Q8BJM1 Q8BJM8 Q8BLS9 Q8K074 Q8R1I7 uc009gyb.1 uc009gyb.2 uc009gyb.3 uc009gyb.4 Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO (NOMO1, NOMO2 or NOMO3) and TMEM147. The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Sequence=AAH24503.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH33923.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC38713.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function endoplasmic reticulum membrane biological_process membrane integral component of membrane carbohydrate binding macromolecular complex uc009gyb.1 uc009gyb.2 uc009gyb.3 uc009gyb.4 
ENSMUST00000033123.8 Abcc8 ENSMUST00000033123.8 ATP-binding cassette, sub-family C member 8, transcript variant 1 (from RefSeq NM_011510.4) Abcc8 B2RUS7 B2RUS7_MOUSE ENSMUST00000033123.1 ENSMUST00000033123.2 ENSMUST00000033123.3 ENSMUST00000033123.4 ENSMUST00000033123.5 ENSMUST00000033123.6 ENSMUST00000033123.7 NM_011510 uc009gye.1 uc009gye.2 uc009gye.3 Interacts with KCNJ11. Membrane ; Multi- pass membrane protein nucleotide binding cellular glucose homeostasis potassium channel activity ATP binding mitochondrion plasma membrane potassium ion transport female pregnancy memory sulfonylurea receptor activity ATP-sensitive potassium channel complex visual learning response to pH response to zinc ion negative regulation of low-density lipoprotein particle clearance membrane integral component of membrane negative regulation of angiogenesis ATPase activity synaptic vesicle membrane response to lipopolysaccharide positive regulation of tumor necrosis factor production response to insulin sarcolemma response to drug ATPase activity, coupled to transmembrane movement of substances positive regulation of potassium ion transport ion channel binding negative regulation of insulin secretion negative regulation of neurogenesis transmembrane transport negative regulation of glial cell proliferation negative regulation of wound healing cellular response to organic substance potassium ion transmembrane transport positive regulation of uterine smooth muscle relaxation positive regulation of voltage-gated potassium channel activity positive regulation of occluding junction disassembly negative regulation of maintenance of permeability of blood-brain barrier uc009gye.1 uc009gye.2 uc009gye.3 
ENSMUST00000033127.12 Sergef ENSMUST00000033127.12 secretion regulating guanine nucleotide exchange factor (from RefSeq NM_013789.2) Delgef ENSMUST00000033127.1 ENSMUST00000033127.10 ENSMUST00000033127.11 ENSMUST00000033127.2 ENSMUST00000033127.3 ENSMUST00000033127.4 ENSMUST00000033127.5 ENSMUST00000033127.6 ENSMUST00000033127.7 ENSMUST00000033127.8 ENSMUST00000033127.9 Gnefr NM_013789 Q0VDT0 Q3UGM8 Q3UKY0 Q80YD6 Q9QXB7 SRGEF_MOUSE uc009gyp.1 uc009gyp.2 uc009gyp.3 uc009gyp.4 Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process. Interacts with SEC5. The interaction occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP (By similarity). Cytoplasm Nucleus guanyl-nucleotide exchange factor activity Ran guanyl-nucleotide exchange factor activity nucleus nucleoplasm cytoplasm cytosol aggresome intracellular membrane-bounded organelle negative regulation of protein secretion uc009gyp.1 uc009gyp.2 uc009gyp.3 uc009gyp.4 
ENSMUST00000033131.12 Lamtor1 ENSMUST00000033131.12 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 (from RefSeq NM_025605.3) ENSMUST00000033131.1 ENSMUST00000033131.10 ENSMUST00000033131.11 ENSMUST00000033131.2 ENSMUST00000033131.3 ENSMUST00000033131.4 ENSMUST00000033131.5 ENSMUST00000033131.6 ENSMUST00000033131.7 ENSMUST00000033131.8 ENSMUST00000033131.9 LTOR1_MOUSE Lamtor1 NM_025605 Q9CQ22 Q9CYS0 uc009ipw.1 uc009ipw.2 uc009ipw.3 uc009ipw.4 Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:19177150, PubMed:29158492, PubMed:30020076). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:19177150, PubMed:29158492, PubMed:30020076). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:19177150). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:19177150). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (By similarity). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (PubMed:30595499). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (By similarity). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (By similarity). May also play a role in RHOA activation (By similarity). Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5 (By similarity). LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer (By similarity). Interacts with LAMTOR2 and LAMTOR3; the interaction is direct (PubMed:19177150). The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and RagD/RRAGD; regulated by amino acid availability (By similarity). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (By similarity). Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator (By similarity). Associates with the lysosomal V-ATPase complex; interaction promotes the guanine nucleotide exchange factor (GEF) of the Ragulator complex (By similarity). Interacts with MMP14 (By similarity). Interacts with CDKN1B; prevents the interaction of CDKN1B with RHOA leaving RHOA in a form accessible to activation by ARHGEF2 (By similarity). Interacts with PIP4P1 (PubMed:29644770). Lysosome membrane ; Lipid-anchor ; Cytoplasmic side Late endosome membrane ; Lipid-anchor ; Cytoplasmic side Note=Recruited to lysosome and endosome membranes through N-terminal myristoylation and palmitoylation. At 6.5 dpc expressed throughout the embryo with relative abundance in the visceral endoderm. N-terminal myristoylation and palmitoylation mediates its recruitment to lysosome membranes, thereby promoting localization of the Ragulator complex to lysosomes. N-myristoylation by NMT1 is required for palmitoylation at Cys-3 and Cys-4. Ubiquitinated at Lys-60, Lys-103 and Lys-104 by UBE3A in neurons, promoting its degradation by the proteasome, thereby limiting mTORC1 signaling and activity-dependent synaptic remodeling (PubMed:30020076). Ubiquitination at Lys-20 impairs the association with the lysosomal V- ATPase complex. Deubiquitination at Lys-20 by USP32 promotes the association with the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (By similarity). Embryos die at egg cylinder stage due to growth retardation, associated with altered endosomes and lysosomes organizations and impaired membrane protein transport in the visceral endoderm. Belongs to the LAMTOR1 family. regulation of cell growth regulation of receptor recycling guanyl-nucleotide exchange factor activity protein binding lysosome lysosomal membrane endosome plasma membrane endosome organization lysosome organization regulation of cholesterol esterification regulation of cholesterol efflux membrane endosomal transport late endosome membrane positive regulation of TOR signaling lysosome localization cellular protein localization cholesterol homeostasis positive regulation of MAPK cascade membrane raft GTPase binding binding, bridging regulation of cholesterol import cellular response to amino acid stimulus Ragulator complex uc009ipw.1 uc009ipw.2 uc009ipw.3 uc009ipw.4 
ENSMUST00000033133.12 Rgs10 ENSMUST00000033133.12 regulator of G-protein signalling 10, transcript variant 10 (from RefSeq NR_184849.1) ENSMUST00000033133.1 ENSMUST00000033133.10 ENSMUST00000033133.11 ENSMUST00000033133.2 ENSMUST00000033133.3 ENSMUST00000033133.4 ENSMUST00000033133.5 ENSMUST00000033133.6 ENSMUST00000033133.7 ENSMUST00000033133.8 ENSMUST00000033133.9 NR_184849 Q9CQE5 Q9D3L2 RGS10_MOUSE uc009jyw.1 uc009jyw.2 uc009jyw.3 Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein. Interacts with GNAZ, GNAI1 and GNAI3. Associates specifically with the activated, GTP-bound forms of GNAZ and GNAI3. Cytoplasm, cytosol Nucleus Note=Forskolin treatment promotes phosphorylation and translocation to the nucleus. G-protein alpha-subunit binding response to amphetamine GTPase activator activity protein binding nucleus cytoplasm cytosol G-protein coupled acetylcholine receptor signaling pathway regulation of G-protein coupled receptor protein signaling pathway negative regulation of signal transduction neuronal cell body dendritic spine positive regulation of GTPase activity axon terminus uc009jyw.1 uc009jyw.2 uc009jyw.3 
ENSMUST00000033135.9 Tial1 ENSMUST00000033135.9 Tia1 cytotoxic granule-associated RNA binding protein-like 1, transcript variant 2 (from RefSeq NM_001347640.1) ENSMUST00000033135.1 ENSMUST00000033135.2 ENSMUST00000033135.3 ENSMUST00000033135.4 ENSMUST00000033135.5 ENSMUST00000033135.6 ENSMUST00000033135.7 ENSMUST00000033135.8 NM_001347640 Q921W2 Q921W2_MOUSE Tial1 uc009jza.1 uc009jza.2 uc009jza.3 nucleic acid binding DNA binding RNA binding uc009jza.1 uc009jza.2 uc009jza.3 
ENSMUST00000033136.9 Bag3 ENSMUST00000033136.9 BCL2-associated athanogene 3 (from RefSeq NM_013863.5) BAG3_MOUSE Bis ENSMUST00000033136.1 ENSMUST00000033136.2 ENSMUST00000033136.3 ENSMUST00000033136.4 ENSMUST00000033136.5 ENSMUST00000033136.6 ENSMUST00000033136.7 ENSMUST00000033136.8 MNCb-2243 NM_013863 Q9CQL3 Q9JJC7 Q9JLV1 uc009jzb.1 uc009jzb.2 uc009jzb.3 uc009jzb.4 uc009jzb.5 Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport. Binds to the ATPase domain of HSP70/HSC70 chaperones. Interacts with BCL2. Interacts with phospholipase C-gamma proteins. Interacts with DNAJB6. Interacts (via BAG domain) with HSF1; this interaction occurs in normal and heat-shocked cells. Interacts with HSPA8 (via NBD), HSPA1A (via NBD) and HSPA1B (via NBD). Interacts (via WW domain 1) with SYNPO2 (via PPPY motif). Q9JLV1; Q8AZK7: EBNA-LP; Xeno; NbExp=2; IntAct=EBI-309231, EBI-1185167; Nucleus Cytoplasm Note=Colocalizes with HSF1 to the nucleus upon heat stress. autophagosome assembly adenyl-nucleotide exchange factor activity stress fiber protein binding nucleus cytoplasm cytosol plasma membrane apoptotic process brain development extrinsic apoptotic signaling pathway via death domain receptors negative regulation of striated muscle cell apoptotic process spinal cord development Z disc cellular response to heat cellular response to unfolded protein positive regulation of protein import into nucleus neuron projection negative regulation of apoptotic process macromolecular complex binding muscle cell cellular homeostasis positive regulation of protein export from nucleus regulation of catalytic activity protein stabilization chaperone binding chaperone-mediated autophagy cellular response to mechanical stimulus extrinsic apoptotic signaling pathway in absence of ligand negative regulation of transcription from RNA polymerase II promoter in response to stress negative regulation of protein targeting to mitochondrion positive regulation of aggrephagy uc009jzb.1 uc009jzb.2 uc009jzb.3 uc009jzb.4 uc009jzb.5 
ENSMUST00000033139.15 Ate1 ENSMUST00000033139.15 arginyltransferase 1, transcript variant 1 (from RefSeq NM_013799.4) ATE1_MOUSE Ate1 ENSMUST00000033139.1 ENSMUST00000033139.10 ENSMUST00000033139.11 ENSMUST00000033139.12 ENSMUST00000033139.13 ENSMUST00000033139.14 ENSMUST00000033139.2 ENSMUST00000033139.3 ENSMUST00000033139.4 ENSMUST00000033139.5 ENSMUST00000033139.6 ENSMUST00000033139.7 ENSMUST00000033139.8 ENSMUST00000033139.9 NM_013799 Q4FCQ6 Q4FCQ7 Q8CFP7 Q9Z2A4 Q9Z2A5 uc009kaa.1 uc009kaa.2 uc009kaa.3 uc009kaa.4 Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues. Reaction=an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl- tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg); Xref=Rhea:RHEA:10208, Rhea:RHEA-COMP:9658, Rhea:RHEA- COMP:9673, Rhea:RHEA-COMP:10636, Rhea:RHEA-COMP:10638, ChEBI:CHEBI:15378, ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:78597, ChEBI:CHEBI:83562; EC=2.3.2.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10209; Evidence=; Monomer (Probable). Interacts with LIAT1; LIAT1 is not a substrate of ATE1, the interaction takes place in the cytoplasm and seems to increase ATE1 arginyltransferase activity (PubMed:25369936, PubMed:33443146). [Isoform ATE1-3]: Interacts with LIAT1; has a higher affinity than the other isoforms. [Isoform ATE1-1]: Nucleus Cytoplasm [Isoform ATE1-2]: Cytoplasm Event=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=ATE1-1; Synonyms=ATE1-1B7A ; IsoId=Q9Z2A5-1; Sequence=Displayed; Name=ATE1-2; Synonyms=ATE1-1B7B ; IsoId=Q9Z2A5-2; Sequence=VSP_000337; Name=ATE1-3; Synonyms=ATE1-1A7A ; IsoId=Q9Z2A5-3; Sequence=VSP_061924; Name=ATE1-4; Synonyms=ATE1-1A7B ; IsoId=Q9Z2A5-4; Sequence=VSP_061924, VSP_000337; Widely expressed. [Isoform ATE1-1]: Shows significantly higher activity than isoform ATE1-2. Belongs to the R-transferase family. arginyltransferase activity protein binding nucleus cytoplasm proteasomal protein catabolic process protein arginylation transferase activity transferase activity, transferring acyl groups uc009kaa.1 uc009kaa.2 uc009kaa.3 uc009kaa.4 
ENSMUST00000033149.5 Cpxm2 ENSMUST00000033149.5 carboxypeptidase X, M14 family member 2 (from RefSeq NM_018867.5) A0A0R4J0C4 A0A0R4J0C4_MOUSE Cpxm2 ENSMUST00000033149.1 ENSMUST00000033149.2 ENSMUST00000033149.3 ENSMUST00000033149.4 NM_018867 uc009kbu.1 uc009kbu.2 uc009kbu.3 uc009kbu.4 Secreted Belongs to the peptidase M14 family. carboxypeptidase activity metallocarboxypeptidase activity proteolysis zinc ion binding uc009kbu.1 uc009kbu.2 uc009kbu.3 uc009kbu.4 
ENSMUST00000033152.5 Chp2 ENSMUST00000033152.5 calcineurin-like EF hand protein 2 (from RefSeq NM_027363.1) CHP2_MOUSE ENSMUST00000033152.1 ENSMUST00000033152.2 ENSMUST00000033152.3 ENSMUST00000033152.4 Hca520 NM_027363 Q0VEK2 Q9D869 uc009jos.1 uc009jos.2 uc009jos.3 Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus (By similarity). Interacts with PPP3CA. Interacts with SLC9A1/NHE1; the interaction occurs in a calcium-dependent manner. Interacts with SLC9A1/NHE1 (By similarity). Cytoplasm Nucleus Cell membrane Note=Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Belongs to the calcineurin regulatory subunit family. CHP subfamily. calcium ion binding nucleus cytoplasm plasma membrane sodium ion transport regulation of pH positive regulation of cell proliferation positive regulation of phosphatase activity protein transport membrane positive regulation of protein import into nucleus positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of calcineurin-NFAT signaling cascade cellular response to calcium ion uc009jos.1 uc009jos.2 uc009jos.3 
ENSMUST00000033153.9 Ern2 ENSMUST00000033153.9 endoplasmic reticulum to nucleus signalling 2, transcript variant 1 (from RefSeq NM_012016.3) ENSMUST00000033153.1 ENSMUST00000033153.2 ENSMUST00000033153.3 ENSMUST00000033153.4 ENSMUST00000033153.5 ENSMUST00000033153.6 ENSMUST00000033153.7 ENSMUST00000033153.8 ERN2_MOUSE Ern2 Ire2 NM_012016 Q3U5E3 Q9Z2E3 uc009joq.1 uc009joq.2 uc009joq.3 uc009joq.4 Role in expression of the DDIT3 transcription factor, required for the unfolded-protein response, growth arrest and apoptosis. Has no effect on 28S ribosomal RNA cleavage, unlike the corresponding human protein. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; The kinase domain is activated by trans- autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain (By similarity). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Autophosphorylated. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding magnesium ion binding catalytic activity endonuclease activity endoribonuclease activity ribonuclease activity protein kinase activity protein serine/threonine kinase activity protein binding ATP binding endoplasmic reticulum endoplasmic reticulum membrane regulation of transcription, DNA-templated mRNA processing protein phosphorylation apoptotic process response to unfolded protein cell cycle arrest activation of JUN kinase activity metabolic process membrane integral component of membrane rRNA catabolic process kinase activity phosphorylation transferase activity hydrolase activity apoptotic chromosome condensation endoplasmic reticulum unfolded protein response response to endoplasmic reticulum stress IRE1-mediated unfolded protein response negative regulation of transcription, DNA-templated metal ion binding unfolded protein binding intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic IRE1-TRAF2-ASK1 complex uc009joq.1 uc009joq.2 uc009joq.3 uc009joq.4 
ENSMUST00000033154.8 Plk1 ENSMUST00000033154.8 polo like kinase 1 (from RefSeq NM_011121.4) ENSMUST00000033154.1 ENSMUST00000033154.2 ENSMUST00000033154.3 ENSMUST00000033154.4 ENSMUST00000033154.5 ENSMUST00000033154.6 ENSMUST00000033154.7 NM_011121 Plk1 Q3TPZ2 Q3TPZ2_MOUSE uc009jop.1 uc009jop.2 uc009jop.3 uc009jop.4 The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and may play a role in DNA replication during S phase. This gene is expressed in all embryonic tissues, but restricted to thymus and ovaries in adult tissues. Homozygous knockout mice were embryonic lethal, suggesting that this gene is important for early embryonic development. This gene is thought to be a potential oncogene because it is overexpressed in a variety of tumors and tumor cell lines. Depletion of this protein in cancer cells has been shown to inhibit cell proliferation and suppress oncogenic transformation; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK148076.1, L19558.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.21; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.21; Evidence= Midbody Nucleus Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. mitotic sister chromatid segregation G2/M transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter establishment of mitotic spindle orientation nucleotide binding mitotic cell cycle mitotic cytokinesis magnesium ion binding kinetochore spindle pole condensed nuclear chromosome outer kinetochore microtubule bundle formation protein kinase activity protein serine/threonine kinase activity ATP binding nucleus centrosome spindle spindle microtubule protein phosphorylation mitotic spindle assembly checkpoint centrosome cycle regulation of mitotic cell cycle microtubule binding positive regulation of peptidyl-threonine phosphorylation anaphase-promoting complex binding microtubule cytoskeleton kinase activity phosphorylation protein ubiquitination transferase activity peptidyl-serine phosphorylation protein kinase binding regulation of mitotic metaphase/anaphase transition midbody protein destabilization positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of cytokinesis identical protein binding negative regulation of apoptotic process regulation of protein binding establishment of protein localization negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of proteolysis nuclear envelope disassembly spindle midzone positive regulation of ubiquitin-protein transferase activity protein localization to chromatin signal transduction involved in G2 DNA damage checkpoint protein localization to nuclear envelope regulation of mitotic spindle assembly positive regulation of ubiquitin protein ligase activity regulation of protein localization to cell cortex uc009jop.1 uc009jop.2 uc009jop.3 uc009jop.4 
ENSMUST00000033156.5 Dctn5 ENSMUST00000033156.5 dynactin 5 (from RefSeq NM_021608.3) DCTN5_MOUSE ENSMUST00000033156.1 ENSMUST00000033156.2 ENSMUST00000033156.3 ENSMUST00000033156.4 NM_021608 Q3U9A4 Q8BPE5 Q91XC6 Q99J17 Q9QZB9 uc009jon.1 uc009jon.2 uc009jon.3 Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. Within the complex DCTN6 forms a heterodimer with DCTN5 (PubMed:10525537). The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin (By similarity). Cytoplasm, cytoskeleton Chromosome, centromere, kinetochore Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily. chromosome, centromeric region kinetochore condensed chromosome kinetochore ventricular septum development molecular_function nucleoplasm chromosome cytoplasm centrosome cytoskeleton nuclear membrane aorta development coronary vasculature development uc009jon.1 uc009jon.2 uc009jon.3 
ENSMUST00000033157.10 Ndufab1 ENSMUST00000033157.10 NADH:ubiquinone oxidoreductase subunit AB1, transcript variant 1 (from RefSeq NM_028177.4) ACPM_MOUSE ENSMUST00000033157.1 ENSMUST00000033157.2 ENSMUST00000033157.3 ENSMUST00000033157.4 ENSMUST00000033157.5 ENSMUST00000033157.6 ENSMUST00000033157.7 ENSMUST00000033157.8 ENSMUST00000033157.9 NM_028177 Ndufab1 Q9CR21 Q9D726 Q9D7V5 uc009joh.1 uc009joh.2 uc009joh.3 Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). Mammalian complex I is composed of 45 different subunits. Interacts with ETFRF1. Identified in a complex composed of MALSU1, MIEF1 upstream open reading frame protein and NDUFAB1; within the trimeric complex, MIEF1 upstream open reading frame protein functions as a bridging scaffold that interacts with MALSU1 on one side, and with NDUFAB1 on the other side. The complex interacts with the mitochondrial large ribosomal subunit. Interacts with alpha-1-microglobulin chain; this interaction is required for the maintenance of mitochondrial redox homeostasis. Component of the mitochondrial core iron-sulfur cluster (ISC) complex composed of NFS1, LYRM4, NDUFAB1, ISCU, FXN, and FDX2; this complex is an heterohexamer containing two copies of each monomer. Component of the cyteine desulfurase complex composed of NFS1, LYRM4 and NDUFAB1; this complex contributes to the stability and cysteine desulfurase activity of NFS1. Mitochondrion Phosphopantetheinylation at Ser-112 is essential for interactions with LYR motif-containing proteins. Belongs to the acyl carrier protein (ACP) family. acyl binding ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process nucleoplasm mitochondrion mitochondrial respiratory chain complex I mitochondrial large ribosomal subunit lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process protein lipoylation mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc009joh.1 uc009joh.2 uc009joh.3 
ENSMUST00000033158.6 Ubfd1 ENSMUST00000033158.6 ubiquitin family domain containing 1 (from RefSeq NM_138589.2) D7Wsu128e ENSMUST00000033158.1 ENSMUST00000033158.2 ENSMUST00000033158.3 ENSMUST00000033158.4 ENSMUST00000033158.5 NM_138589 Q78JW9 UBFD1_MOUSE uc009jog.1 uc009jog.2 uc009jog.3 uc009jog.1 uc009jog.2 uc009jog.3 
ENSMUST00000033159.4 Ears2 ENSMUST00000033159.4 glutamyl-tRNA synthetase 2, mitochondrial (from RefSeq NM_026140.3) ENSMUST00000033159.1 ENSMUST00000033159.2 ENSMUST00000033159.3 Ears2 Kiaa1970 NM_026140 Q3TJB3 Q9CXJ1 SYEM_MOUSE uc009joe.1 uc009joe.2 uc009joe.3 uc009joe.4 This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in a similar gene in human have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). [provided by RefSeq, Mar 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK014324.2, AK167506.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Non-discriminating glutamyl-tRNA synthetase that catalyzes aminoacylation of both mitochondrial tRNA(Glu) and tRNA(Gln) and participates in RNA aminoacylation for mitochondrial protein translation. Attachs glutamate to tRNA(Glu) or tRNA(Gln) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) or tRNA(Gln). In vitro, cytoplasmic tRNA(Gln) is slightly glutamylated, but with low activity. Reaction=ATP + L-glutamate + tRNA(Glx) = AMP + diphosphate + L- glutamyl-tRNA(Glx); Xref=Rhea:RHEA:18397, Rhea:RHEA-COMP:9713, Rhea:RHEA-COMP:9716, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78520, ChEBI:CHEBI:456215; EC=6.1.1.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18398; Evidence=; Reaction=ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L- glutamyl-tRNA(Glu); Xref=Rhea:RHEA:23540, Rhea:RHEA-COMP:9663, Rhea:RHEA-COMP:9680, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78520, ChEBI:CHEBI:456215; EC=6.1.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23541; Evidence=; Reaction=ATP + L-glutamate + tRNA(Gln) = AMP + diphosphate + L- glutamyl-tRNA(Gln); Xref=Rhea:RHEA:64612, Rhea:RHEA-COMP:9662, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78520, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64613; Evidence=; Mitochondrion matrix Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. tRNA binding nucleotide binding RNA binding aminoacyl-tRNA ligase activity glutamate-tRNA ligase activity ATP binding mitochondrion mitochondrial matrix translation tRNA aminoacylation for protein translation glutamyl-tRNA aminoacylation zinc ion binding ligase activity tRNA aminoacylation glutamate-tRNA(Gln) ligase activity tRNA aminoacylation for mitochondrial protein translation uc009joe.1 uc009joe.2 uc009joe.3 uc009joe.4 
ENSMUST00000033160.15 Gga2 ENSMUST00000033160.15 golgi associated, gamma adaptin ear containing, ARF binding protein 2 (from RefSeq NM_028758.2) ENSMUST00000033160.1 ENSMUST00000033160.10 ENSMUST00000033160.11 ENSMUST00000033160.12 ENSMUST00000033160.13 ENSMUST00000033160.14 ENSMUST00000033160.2 ENSMUST00000033160.3 ENSMUST00000033160.4 ENSMUST00000033160.5 ENSMUST00000033160.6 ENSMUST00000033160.7 ENSMUST00000033160.8 ENSMUST00000033160.9 GGA2_MOUSE Kiaa1080 NM_028758 Q3U374 Q6P5E6 Q6PFX3 Q6ZPY8 Q8BM76 Q9DC15 uc009joa.1 uc009joa.2 uc009joa.3 Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network. Monomer (By similarity). Interacts with NECAP1, TSG101, UBC and AFTPH/aftiphilin. Interacts with CNST (PubMed:19864490). Interacts with GGA1 and GGA3 (By similarity). Binds to clathrin and activated ARFs, such as ARF1, ARF5 and ARF6 (PubMed:11950392). Binds RABEP1 and RABGEF1. Interacts with the type-I membrane proteins LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Interacts (via N-terminal VHS domain) with SORL1/sorLA and SORT1 (via C-terminal cytosolic domain) (By similarity). Binds the accessory proteins CCDC91, P200, SYNRG, EPN4 and NECAP2. Interacts with ADRA2B. Interacts (via VHS domain) with PIK4B; the interaction is important for PIK4B location at the Golgi apparatus membrane (By similarity). Q6P5E6; Q8CBC4-3: Cnst; NbExp=2; IntAct=EBI-2616239, EBI-2615407; Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Early endosome membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P5E6-1; Sequence=Displayed; Name=2; IsoId=Q6P5E6-2; Sequence=VSP_013255; The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (DXXLL motif). The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis. The unstructured hinge region contains clathrin-binding but no autoinhibitory (DXXLL) motifs. The GAE domain binds accessory proteins regulating GGAs function. Ubiquitinated. Belongs to the GGA protein family. Sequence=BAC28769.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC98090.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding endosome Golgi apparatus trans-Golgi network intracellular protein transport endosome membrane protein transport membrane vesicle-mediated transport clathrin-coated vesicle ADP-ribosylation factor binding early endosome membrane protein localization to cell surface Golgi to plasma membrane protein transport uc009joa.1 uc009joa.2 uc009joa.3 
ENSMUST00000033161.7 Scnn1b ENSMUST00000033161.7 sodium channel, nonvoltage-gated 1 beta, transcript variant 1 (from RefSeq NM_011325.2) ENSMUST00000033161.1 ENSMUST00000033161.2 ENSMUST00000033161.3 ENSMUST00000033161.4 ENSMUST00000033161.5 ENSMUST00000033161.6 NM_011325 Q9WU38 SCNNB_MOUSE uc009jnx.1 uc009jnx.2 uc009jnx.3 uc009jnx.4 Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Activated by WNK1, WNK2, WNK3 and WNK4. Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties (By similarity). Interacts with NEDD4 (via WW domains) (PubMed:11244092, PubMed:15123669). Interacts with NEDD4L (via WW domains) (PubMed:11244092, PubMed:12424229, PubMed:15123669). Interacts with WWP1 (via WW domains). Interacts with WWP2 (via WW domains). Interacts with the full-length immature form of PCSK9 (pro-PCSK9) (By similarity). Interacts (N-glycosylated) with BPIFA1; the interaction is direct and inhibits the proteolytic processing of SCNN1A and SCNN1G and the activation of ENaC (By similarity). Apical cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane Note=Apical membrane of epithelial cells. Lung and kidney. N-glycosylated. N-glycosylation is required for interaction with BPIFA1. Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily. regulation of sodium ion transport sodium channel activity protein binding plasma membrane integral component of plasma membrane ion transport sodium ion transport external side of plasma membrane cell surface ligand-gated sodium channel activity membrane integral component of membrane apical plasma membrane cytoplasmic vesicle membrane cytoplasmic vesicle sodium channel complex wound healing, spreading of epidermal cells sodium ion transmembrane transport WW domain binding multicellular organismal water homeostasis response to stimulus sensory perception of taste sodium ion homeostasis extracellular exosome uc009jnx.1 uc009jnx.2 uc009jnx.3 uc009jnx.4 
ENSMUST00000033163.8 Mettl9 ENSMUST00000033163.8 methyltransferase like 9, transcript variant 1 (from RefSeq NM_021554.3) A0JG25 ENSMUST00000033163.1 ENSMUST00000033163.2 ENSMUST00000033163.3 ENSMUST00000033163.4 ENSMUST00000033163.5 ENSMUST00000033163.6 ENSMUST00000033163.7 METL9_MOUSE MNCb-5680 Mettl9 NM_021554 Q3TDX0 Q641L4 Q8R567 Q9EPL3 Q9EPL4 Q9JJ88 drev uc009jnk.1 uc009jnk.2 Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (PubMed:33563959, PubMed:34218407). Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid) (PubMed:33563959, PubMed:34218407). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (PubMed:33563959, PubMed:34218407). Constitutes the main methyltransferase for the 1-methylhistidine modification in cell (PubMed:33563959). Reaction=L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:67076, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:17184, ChEBI:CHEBI:15378, ChEBI:CHEBI:29979, ChEBI:CHEBI:43903, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67077; Evidence=; Endoplasmic reticulum Mitochondrion Note=Colocalizes with membranous compartments such as the endoplasmic reticulum and mitochondria. Expressed in liver, colon, small intestine, skin, kidney and to a lesser extent in spleen, lung, thymus and stomach. Not detected in fibroblast and endothelial cells. Belongs to the METTL9 family. Sequence=AAH23188.1; Type=Erroneous initiation; Evidence=; Sequence=BAA95109.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc009jnk.1 uc009jnk.2 
ENSMUST00000033166.10 Mfsd13b ENSMUST00000033166.10 major facilitator superfamily domain containing 13B, transcript variant 2 (from RefSeq NM_028955.1) 4933427G17Rik ENSMUST00000033166.1 ENSMUST00000033166.2 ENSMUST00000033166.3 ENSMUST00000033166.4 ENSMUST00000033166.5 ENSMUST00000033166.6 ENSMUST00000033166.7 ENSMUST00000033166.8 ENSMUST00000033166.9 Mfsd13b NM_028955 Q9D3Y2 Q9D3Y2_MOUSE uc009jnj.1 uc009jnj.2 molecular_function cellular_component biological_process membrane integral component of membrane uc009jnj.1 uc009jnj.2 
ENSMUST00000033169.9 Cdr2 ENSMUST00000033169.9 cerebellar degeneration-related 2, transcript variant 1 (from RefSeq NM_007672.2) CDR2_MOUSE ENSMUST00000033169.1 ENSMUST00000033169.2 ENSMUST00000033169.3 ENSMUST00000033169.4 ENSMUST00000033169.5 ENSMUST00000033169.6 ENSMUST00000033169.7 ENSMUST00000033169.8 NM_007672 P97817 Q3UG92 uc012ftc.1 uc012ftc.2 uc012ftc.3 uc012ftc.4 Expressed in brain and testis (at protein level). Expressed in the cerebellum, cerebral cortex, heart, lung, spleen, ovary, kidney and testis. Belongs to the CDR2 family. molecular_function cytoplasm biological_process uc012ftc.1 uc012ftc.2 uc012ftc.3 uc012ftc.4 
ENSMUST00000033173.15 Polr3e ENSMUST00000033173.15 polymerase (RNA) III (DNA directed) polypeptide E, transcript variant 5 (from RefSeq NR_166591.1) ENSMUST00000033173.1 ENSMUST00000033173.10 ENSMUST00000033173.11 ENSMUST00000033173.12 ENSMUST00000033173.13 ENSMUST00000033173.14 ENSMUST00000033173.2 ENSMUST00000033173.3 ENSMUST00000033173.4 ENSMUST00000033173.5 ENSMUST00000033173.6 ENSMUST00000033173.7 ENSMUST00000033173.8 ENSMUST00000033173.9 NR_166591 Polr3e Q8CI35 Q9CZT4 Q9DBD1 RPC5_MOUSE Sin uc009jnf.1 uc009jnf.2 uc009jnf.3 uc009jnf.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3D/RPC4 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity). Component of the RNA polymerase III complex consisting of at least 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; the stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, forming a structural mobile part that protrudes out of the core and functions primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3D/RPC4-POLR3E/RPC5 heterodimer and POLR3/CRPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZT4-1; Sequence=Displayed; Name=2; IsoId=Q9CZT4-2; Sequence=VSP_007066; immune system process DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm DNA-directed RNA polymerase III complex transcription, DNA-templated transcription from RNA polymerase III promoter innate immune response defense response to virus RNA polymerase III activity uc009jnf.1 uc009jnf.2 uc009jnf.3 uc009jnf.4 
ENSMUST00000033176.7 Uqcrc2 ENSMUST00000033176.7 ubiquinol cytochrome c reductase core protein 2 (from RefSeq NM_025899.2) ENSMUST00000033176.1 ENSMUST00000033176.2 ENSMUST00000033176.3 ENSMUST00000033176.4 ENSMUST00000033176.5 ENSMUST00000033176.6 NM_025899 Q8BK11 Q9CVK7 Q9DB77 QCR2_MOUSE uc009jms.1 uc009jms.2 uc009jms.3 Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (By similarity). Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:19026783, PubMed:30666338). Interacts with RAB5IF (PubMed:31536960). Interacts with STMP1 (PubMed:35101990). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Expressed in neurons and astrocytes of the cerebral cortex and hippocampus (at protein level). Acetylation of Lys-159 and Lys-250 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily. catalytic activity metalloendopeptidase activity nucleoplasm mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex III mitochondrial respiratory chain complex IV proteolysis protein processing involved in protein targeting to mitochondrion membrane mitochondrial processing peptidase complex response to drug myelin sheath macromolecular complex binding metal ion binding oxidation-reduction process respiratory chain endopeptidase activity uc009jms.1 uc009jms.2 uc009jms.3 
ENSMUST00000033178.4 Pdzd9 ENSMUST00000033178.4 PDZ domain containing 9, transcript variant 2 (from RefSeq NM_001040137.3) ENSMUST00000033178.1 ENSMUST00000033178.2 ENSMUST00000033178.3 NM_001040137 PDZD9_MOUSE Q9CR71 Q9D9M4 uc009jmu.1 uc009jmu.2 uc009jmu.3 molecular_function cellular_component biological_process uc009jmu.1 uc009jmu.2 uc009jmu.3 
ENSMUST00000033179.14 Rrp8 ENSMUST00000033179.14 ribosomal RNA processing 8, transcript variant 2 (from RefSeq NM_025897.2) ENSMUST00000033179.1 ENSMUST00000033179.10 ENSMUST00000033179.11 ENSMUST00000033179.12 ENSMUST00000033179.13 ENSMUST00000033179.2 ENSMUST00000033179.3 ENSMUST00000033179.4 ENSMUST00000033179.5 ENSMUST00000033179.6 ENSMUST00000033179.7 ENSMUST00000033179.8 ENSMUST00000033179.9 NM_025897 Q3T9X9 Q3TDD7 Q3U3A5 Q8BHW3 Q9DB85 RRP8_MOUSE uc009iyz.1 uc009iyz.2 uc009iyz.3 uc009iyz.4 Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown (By similarity). Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. Nucleus, nucleolus Note=Localizes at rDNA locus. Belongs to the methyltransferase superfamily. RRP8 family. Sequence=BAC37008.1; Type=Frameshift; Evidence=; chromatin silencing at rDNA nucleus chromatin silencing complex nucleolus cytosol plasma membrane chromatin organization rRNA processing methyltransferase activity transferase activity methylation rDNA heterochromatin methylated histone binding cellular response to glucose starvation regulation of transcription by glucose positive regulation of cell cycle arrest intrinsic apoptotic signaling pathway by p53 class mediator uc009iyz.1 uc009iyz.2 uc009iyz.3 uc009iyz.4 
ENSMUST00000033180.13 Vwa3a ENSMUST00000033180.13 von Willebrand factor A domain containing 3A (from RefSeq NM_177697.3) ENSMUST00000033180.1 ENSMUST00000033180.10 ENSMUST00000033180.11 ENSMUST00000033180.12 ENSMUST00000033180.2 ENSMUST00000033180.3 ENSMUST00000033180.4 ENSMUST00000033180.5 ENSMUST00000033180.6 ENSMUST00000033180.7 ENSMUST00000033180.8 ENSMUST00000033180.9 NM_177697 Q3UVV9 Q8C349 VWA3A_MOUSE uc009jna.1 uc009jna.2 uc009jna.3 Sequence=BAC39770.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; Sequence=BAC39770.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc009jna.1 uc009jna.2 uc009jna.3 
ENSMUST00000033182.10 Ilk ENSMUST00000033182.10 integrin linked kinase, transcript variant 1 (from RefSeq NM_001161724.1) ENSMUST00000033182.1 ENSMUST00000033182.2 ENSMUST00000033182.3 ENSMUST00000033182.4 ENSMUST00000033182.5 ENSMUST00000033182.6 ENSMUST00000033182.7 ENSMUST00000033182.8 ENSMUST00000033182.9 ILK1 ILK2 ILK_MOUSE Ilk NM_001161724 O55222 Q78KK2 uc009izb.1 uc009izb.2 uc009izb.3 uc009izb.4 Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin, in a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK. The protein kinase activity is stimulated by LIMD2. Interacts with the cytoplasmic domain of ITGB1. Could also interact with integrin ITGB2, ITGB3 and/or ITGB5. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with PARVA (via C-terminus) and PARVB; these compete for the same binding site (By similarity). Interacts probably also with TGFB1I1 (PubMed:16737959). Interacts (via ANK repeats) with EPHA1 (via SAM domain); stimulated by EFNA1 but independent of the kinase activity of EPHA1 (By similarity). Interacts with FERMT2 (PubMed:18483218). Interacts with LIMD2; leading to activate the protein kinase activity. Interacts with PXN/PAXILLIN (via LD motif 4). Interacts with CCDC25 (via cytoplasmic region); initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (By similarity). O55222; Q9EPC1: Parva; NbExp=7; IntAct=EBI-6690138, EBI-6690233; O55222; Q9ES46: Parvb; NbExp=3; IntAct=EBI-6690138, EBI-6914996; O55222; Q9WUD1: Stub1; NbExp=7; IntAct=EBI-6690138, EBI-773027; O55222; P48059: LIMS1; Xeno; NbExp=4; IntAct=EBI-6690138, EBI-306928; O55222; Q9NVD7: PARVA; Xeno; NbExp=2; IntAct=EBI-6690138, EBI-747655; Cell junction, focal adhesion Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, myofibril, sarcomere Cell projection, lamellipodium Highly expressed in lung, heart, kidney, liver, brain, spleen and skeletal muscle. Weakly expressed in testis. A PH-like domain is involved in phosphatidylinositol phosphate binding. Autophosphorylated on serine residues. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. nucleotide binding regulation of cell growth branching involved in ureteric bud morphogenesis stress fiber positive regulation of protein phosphorylation positive regulation of cell-matrix adhesion outflow tract morphogenesis protein kinase activity protein serine/threonine kinase activity integrin binding protein binding ATP binding nucleoplasm cytoplasm cytosol plasma membrane cell-cell junction focal adhesion protein phosphorylation negative regulation of protein kinase activity cell cycle arrest cell-matrix adhesion integrin-mediated signaling pathway cell aging positive regulation of cell proliferation positive regulation of signal transduction negative regulation of cardiac muscle cell apoptotic process fibroblast migration Schwann cell development negative regulation of smooth muscle cell migration membrane kinase activity phosphorylation transferase activity SH3 domain binding peptidyl-serine phosphorylation protein kinase binding protein domain specific binding nerve development myelination in peripheral nervous system sarcomere lamellipodium cell projection organization cell junction positive regulation of cell migration axon positive regulation of BMP signaling pathway myelin assembly regulation of actin cytoskeleton organization macromolecular complex tumor necrosis factor-mediated signaling pathway substrate adhesion-dependent cell spreading positive regulation of phosphorylation cell projection neuronal cell body costamere negative regulation of apoptotic process terminal bouton dendritic shaft positive regulation of MAP kinase activity positive regulation of MAPK cascade protein kinase B signaling negative regulation of neuron apoptotic process establishment or maintenance of epithelial cell apical/basal polarity positive regulation of myoblast differentiation positive regulation of osteoblast differentiation positive regulation of axon extension positive regulation of transcription, DNA-templated negative regulation of smooth muscle cell proliferation neuron projection morphogenesis positive regulation of axonogenesis positive regulation of dendrite morphogenesis protein heterooligomerization positive regulation of protein kinase B signaling positive regulation of canonical Wnt signaling pathway supramolecular fiber organization positive regulation of NIK/NF-kappaB signaling negative regulation of neural precursor cell proliferation uc009izb.1 uc009izb.2 uc009izb.3 uc009izb.4 
ENSMUST00000033184.6 Tpp1 ENSMUST00000033184.6 tripeptidyl peptidase I (from RefSeq NM_009906.6) Cln2 ENSMUST00000033184.1 ENSMUST00000033184.2 ENSMUST00000033184.3 ENSMUST00000033184.4 ENSMUST00000033184.5 NM_009906 O89023 Q543Q8 Q9QUS7 TPP1_MOUSE uc009izg.1 uc009izg.2 uc009izg.3 uc009izg.4 This gene encodes a lysosomal serine protease that cleaves N-terminal tripeptides from protein substrates. The encoded preproprotein undergoes autocatalytic processing to generate a mature enzyme. Mice lacking the encoded protein exhibit a progressive neurodegeneration and a greatly shortened lifespan. At the cellular level, mice lacking the encoded protein exhibit accumulation of autofluorescent lipopigments. Mutations in the human ortholog of this gene cause classical late-infantile neuronal ceroid lipofuscinosis. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK155021.1, AK048279.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Lysosomal serine protease with tripeptidyl-peptidase I activity (PubMed:28464005). May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (By similarity). Requires substrates with an unsubstituted N-terminus (By similarity). Reaction=Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.; EC=3.4.14.9; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Monomer (By similarity). Interacts with CLN5 (PubMed:19941651). Interacts with CLN3 (By similarity). O89023; Q91WC1: Pot1; NbExp=2; IntAct=EBI-7051084, EBI-7051001; Lysosome Melanosome Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity (By similarity). Sequence=CAA09863.1; Type=Erroneous initiation; Evidence=; endopeptidase activity serine-type endopeptidase activity protein binding mitochondrion lysosome proteolysis lysosome organization nervous system development central nervous system development peptidase activity serine-type peptidase activity tripeptidyl-peptidase activity hydrolase activity epithelial cell differentiation peptide binding melanosome peptide catabolic process bone resorption metal ion binding neuromuscular process controlling balance uc009izg.1 uc009izg.2 uc009izg.3 uc009izg.4 
ENSMUST00000033185.10 Hpx ENSMUST00000033185.10 hemopexin (from RefSeq NM_017371.2) ENSMUST00000033185.1 ENSMUST00000033185.2 ENSMUST00000033185.3 ENSMUST00000033185.4 ENSMUST00000033185.5 ENSMUST00000033185.6 ENSMUST00000033185.7 ENSMUST00000033185.8 ENSMUST00000033185.9 HEMO_MOUSE Hpxn NM_017371 P97824 Q3UKP2 Q8WUP0 Q91X72 uc009iyl.1 uc009iyl.2 uc009iyl.3 uc009iyl.4 Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. Secreted. Expressed by the liver and secreted in plasma. The isolated N-terminal domain binds one heme. The full- length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity). Belongs to the hemopexin family. positive regulation of immunoglobulin production positive regulation of humoral immune response mediated by circulating immunoglobulin extracellular region extracellular space cell cellular iron ion homeostasis heme transporter activity heme transport hemoglobin metabolic process heme binding heme metabolic process positive regulation of tyrosine phosphorylation of STAT protein metal ion binding regulation of protein metabolic process positive regulation of response to interferon-gamma positive regulation of interferon-gamma-mediated signaling pathway uc009iyl.1 uc009iyl.2 uc009iyl.3 uc009iyl.4 
ENSMUST00000033187.6 Cnga4 ENSMUST00000033187.6 cyclic nucleotide gated channel alpha 4 (from RefSeq NM_001033317.3) CNGA4_MOUSE ENSMUST00000033187.1 ENSMUST00000033187.2 ENSMUST00000033187.3 ENSMUST00000033187.4 ENSMUST00000033187.5 NM_001033317 Q08EL1 Q3UW12 uc009iyc.1 uc009iyc.2 uc009iyc.3 Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection. Calcium-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif of CNGA4 and preferably binds to the channel in the closed state. Inhibition by PIP3 of the CNG channel probably occurs via CGNA2 binding (By similarity). Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory neurons (By similarity). Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UW12-1; Sequence=Displayed; Name=2; IsoId=Q3UW12-2; Sequence=VSP_030873; The C-terminal coiled-coil domain mediates trimerization of CNGA subunits. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily. nucleotide binding ion channel activity intracellular cyclic nucleotide activated cation channel activity intracellular cAMP activated cation channel activity intracellular cGMP activated cation channel activity plasma membrane ion transport sensory perception of smell membrane integral component of membrane intracellular cyclic nucleotide activated cation channel complex cAMP binding cGMP binding ion transmembrane transport perikaryon response to stimulus protein heterotetramerization transmembrane transport cation transmembrane transport uc009iyc.1 uc009iyc.2 uc009iyc.3 
ENSMUST00000033189.6 Cckbr ENSMUST00000033189.6 cholecystokinin B receptor, transcript variant 3 (from RefSeq NR_178082.1) Cckbr ENSMUST00000033189.1 ENSMUST00000033189.2 ENSMUST00000033189.3 ENSMUST00000033189.4 ENSMUST00000033189.5 NR_178082 Q3ZB46 Q3ZB46_MOUSE uc009iyd.1 uc009iyd.2 uc009iyd.3 Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity cholecystokinin receptor activity cell signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of cell proliferation gastrin receptor activity membrane integral component of membrane peptide hormone binding type B gastrin/cholecystokinin receptor binding cholecystokinin signaling pathway uc009iyd.1 uc009iyd.2 uc009iyd.3 
ENSMUST00000033198.6 Crym ENSMUST00000033198.6 crystallin, mu (from RefSeq NM_016669.2) Crym ENSMUST00000033198.1 ENSMUST00000033198.2 ENSMUST00000033198.3 ENSMUST00000033198.4 ENSMUST00000033198.5 NM_016669 Q3UPX0 Q3UPX0_MOUSE uc009jmk.1 uc009jmk.2 uc009jmk.3 Reaction=(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) = 3,4- dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:12504, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58517, ChEBI:CHEBI:176873; EC=1.5.1.25; Evidence=; Reaction=(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4- dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH; Xref=Rhea:RHEA:12500, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58517, ChEBI:CHEBI:176873; EC=1.5.1.25; Evidence=; Belongs to the ornithine cyclodeaminase/mu-crystallin family. negative regulation of transcription from RNA polymerase II promoter transcription corepressor activity cytoplasm cytosol sensory perception of sound protein homodimerization activity NADP binding thyroid hormone binding thyroid hormone transport uc009jmk.1 uc009jmk.2 uc009jmk.3 
ENSMUST00000033201.7 Anks4b ENSMUST00000033201.7 ankyrin repeat and sterile alpha motif domain containing 4B (from RefSeq NM_028085.2) ANS4B_MOUSE Anks4b ENSMUST00000033201.1 ENSMUST00000033201.2 ENSMUST00000033201.3 ENSMUST00000033201.4 ENSMUST00000033201.5 ENSMUST00000033201.6 Harp NM_028085 Q148R3 Q8K3X6 Q9D8A5 uc009jmj.1 uc009jmj.2 uc009jmj.3 uc009jmj.4 As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (By similarity). May play a role in cellular response to endoplasmic reticulum stress (PubMed:22589549). Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5 (By similarity). Interacts with USH1C; the interaction is direct and is required for ANKS4B localization to the tip of microvilli (PubMed:15461667, PubMed:26812017). Interacts with MYO7B; the interaction is direct (PubMed:26812017). May interact with HSPA5 (PubMed:22589549). Cell projection, microvillus Note=Localizes at the tip of microvilli (PubMed:26812018). May associate with endoplasmic reticulum membranes (PubMed:22589549). Cochlea, kidney, lung, liver, pancreas, salivary gland and small intestine (at protein level). Expressed in kidney, small intestine, pancreas, liver and colon. Not detected in heart, spleen and brain. protein binding endoplasmic reticulum membrane plasma membrane microvillus brush border cell differentiation cellular macromolecular complex assembly response to endoplasmic reticulum stress cell projection protein localization to microvillus brush border assembly uc009jmj.1 uc009jmj.2 uc009jmj.3 uc009jmj.4 
ENSMUST00000033210.13 Ldaf1 ENSMUST00000033210.13 lipid droplet assembly factor 1, transcript variant 5 (from RefSeq NR_185056.1) ENSMUST00000033210.1 ENSMUST00000033210.10 ENSMUST00000033210.11 ENSMUST00000033210.12 ENSMUST00000033210.2 ENSMUST00000033210.3 ENSMUST00000033210.4 ENSMUST00000033210.5 ENSMUST00000033210.6 ENSMUST00000033210.7 ENSMUST00000033210.8 ENSMUST00000033210.9 LDAF1_MOUSE Ldaf1 NR_185056 Q8C5E0 Q922Z1 Tmem159 uc009jmh.1 uc009jmh.2 uc009jmh.3 Plays an important role in the formation of lipid droplets (LD) which are storage organelles at the center of lipid and energy homeostasis (By similarity). In association with BSCL2/seipin, defines the sites of LD formation in the endoplasmic reticulum (By similarity). Interacts with BSCL2/seipin to form an oligomeric complex. Endoplasmic reticulum membrane ; Multi-pass membrane protein Lipid droplet Note=Co- localizes with BSCL2/seipin in the ER, upon LD formation dissociates from BSCL2/seipin and relocalizes to LD surfaces during LD maturation. Prominently expressed in the heart and kidney. Expressed at higher levels in white fat as compared to brown fat and skeletal muscle. Expressed at lower levels in lung, liver and testis. In liver with hepatic adiposis caused by PPAR gamma 1 overexpression (PubMed:15589683). Up-regulated during adipogenesis (PubMed:30901948). Belongs to the LDAF1 family. molecular_function cellular_component biological_process membrane integral component of membrane uc009jmh.1 uc009jmh.2 uc009jmh.3 
ENSMUST00000033211.14 Trim30d ENSMUST00000033211.14 tripartite motif-containing 30D, transcript variant 1 (from RefSeq NM_199146.2) E9PWL0 E9PWL0_MOUSE ENSMUST00000033211.1 ENSMUST00000033211.10 ENSMUST00000033211.11 ENSMUST00000033211.12 ENSMUST00000033211.13 ENSMUST00000033211.2 ENSMUST00000033211.3 ENSMUST00000033211.4 ENSMUST00000033211.5 ENSMUST00000033211.6 ENSMUST00000033211.7 ENSMUST00000033211.8 ENSMUST00000033211.9 NM_199146 Trim30d uc009iwj.1 uc009iwj.2 uc009iwj.3 uc009iwj.4 uc009iwj.5 Belongs to the TRIM/RBCC family. molecular_function ubiquitin-protein transferase activity cellular_component autophagy biological_process zinc ion binding protein ubiquitination innate immune response metal ion binding defense response to virus uc009iwj.1 uc009iwj.2 uc009iwj.3 uc009iwj.4 uc009iwj.5 
ENSMUST00000033229.5 Hbb-y ENSMUST00000033229.5 hemoglobin Y, beta-like embryonic chain (from RefSeq NM_008221.4) ENSMUST00000033229.1 ENSMUST00000033229.2 ENSMUST00000033229.3 ENSMUST00000033229.4 Glnb1 Hbb-y NM_008221 Q9CR49 Q9CR49_MOUSE uc009iut.1 uc009iut.2 uc009iut.3 Belongs to the globin family. oxygen transporter activity hemoglobin complex response to organic cyclic compound oxygen transport oxygen binding heme binding hemoglobin alpha binding metal ion binding protein heterooligomerization uc009iut.1 uc009iut.2 uc009iut.3 
ENSMUST00000033230.8 Tha1 ENSMUST00000033230.8 threonine aldolase 1 (from RefSeq NM_027919.4) ENSMUST00000033230.1 ENSMUST00000033230.2 ENSMUST00000033230.3 ENSMUST00000033230.4 ENSMUST00000033230.5 ENSMUST00000033230.6 ENSMUST00000033230.7 Gly1 NM_027919 Q6XPS7 Q6XPS7_MOUSE Tha1 uc007moh.1 uc007moh.2 uc007moh.3 uc007moh.4 Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Belongs to the threonine aldolase family. catalytic activity cytosol cellular amino acid metabolic process glycine biosynthetic process threonine catabolic process L-allo-threonine aldolase activity lyase activity uc007moh.1 uc007moh.2 uc007moh.3 uc007moh.4 
ENSMUST00000033236.9 Thumpd1 ENSMUST00000033236.9 THUMP domain containing 1 (from RefSeq NM_145585.3) ENSMUST00000033236.1 ENSMUST00000033236.2 ENSMUST00000033236.3 ENSMUST00000033236.4 ENSMUST00000033236.5 ENSMUST00000033236.6 ENSMUST00000033236.7 ENSMUST00000033236.8 NM_145585 Q3U6Y3 Q99J36 THUM1_MOUSE uc009jlo.1 uc009jlo.2 uc009jlo.3 uc009jlo.4 Functions as a tRNA-binding adapter to mediate NAT10- dependent tRNA acetylation modifying cytidine to N4-acetylcytidine (ac4C). Interacts with NAT10. Binds tRNA. Belongs to the THUMPD1 family. RNA binding cellular_component tRNA modification uc009jlo.1 uc009jlo.2 uc009jlo.3 uc009jlo.4 
ENSMUST00000033241.6 Lhpp ENSMUST00000033241.6 phospholysine phosphohistidine inorganic pyrophosphate phosphatase (from RefSeq NM_029609.1) ENSMUST00000033241.1 ENSMUST00000033241.2 ENSMUST00000033241.3 ENSMUST00000033241.4 ENSMUST00000033241.5 LHPP_MOUSE NM_029609 Q3USP1 Q6P070 Q9D7I5 uc009kce.1 uc009kce.2 uc009kce.3 Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474; EC=3.6.1.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Homodimer. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D7I5-1; Sequence=Displayed; Name=2; IsoId=Q9D7I5-2; Sequence=VSP_028214, VSP_028215; Belongs to the HAD-like hydrolase superfamily. magnesium ion binding inorganic diphosphatase activity nucleus cytoplasm cytosol protein dephosphorylation phosphate-containing compound metabolic process dephosphorylation nuclear speck hydrolase activity phosphatase activity protein homodimerization activity metal ion binding protein histidine phosphatase activity uc009kce.1 uc009kce.2 uc009kce.3 
ENSMUST00000033257.15 Eef1akmt2 ENSMUST00000033257.15 EEF1A lysine methyltransferase 2, transcript variant 1 (from RefSeq NM_028095.1) EFMT2_MOUSE ENSMUST00000033257.1 ENSMUST00000033257.10 ENSMUST00000033257.11 ENSMUST00000033257.12 ENSMUST00000033257.13 ENSMUST00000033257.14 ENSMUST00000033257.2 ENSMUST00000033257.3 ENSMUST00000033257.4 ENSMUST00000033257.5 ENSMUST00000033257.6 ENSMUST00000033257.7 ENSMUST00000033257.8 ENSMUST00000033257.9 Eef1akmt2 Mettl10 NM_028095 Q4V9Y9 Q9D853 uc009kcm.1 uc009kcm.2 uc009kcm.3 uc009kcm.4 Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54193; Evidence=; Cytoplasm Nucleus Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family. nucleus cytoplasm methyltransferase activity protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine methylation peptidyl-lysine monomethylation peptidyl-lysine dimethylation methylation uc009kcm.1 uc009kcm.2 uc009kcm.3 uc009kcm.4 
ENSMUST00000033264.12 Trim21 ENSMUST00000033264.12 tripartite motif-containing 21, transcript variant 1 (from RefSeq NM_009277.4) ENSMUST00000033264.1 ENSMUST00000033264.10 ENSMUST00000033264.11 ENSMUST00000033264.2 ENSMUST00000033264.3 ENSMUST00000033264.4 ENSMUST00000033264.5 ENSMUST00000033264.6 ENSMUST00000033264.7 ENSMUST00000033264.8 ENSMUST00000033264.9 NM_009277 Q3U7K7 Q3U7K7_MOUSE Trim21 uc009irw.1 uc009irw.2 uc009irw.3 uc009irw.4 Protein modification; protein ubiquitination. Belongs to the TRIM/RBCC family. protein polyubiquitination ubiquitin-protein transferase activity nucleus nucleoplasm cytoplasm protein monoubiquitination zinc ion binding positive regulation of autophagy protein ubiquitination SCF ubiquitin ligase complex protein destabilization negative regulation of NF-kappaB transcription factor activity negative regulation of viral transcription response to interferon-gamma identical protein binding innate immune response positive regulation of cell cycle positive regulation of viral entry into host cell metal ion binding positive regulation of sequence-specific DNA binding transcription factor activity protein autoubiquitination protein trimerization negative regulation of protein deubiquitination negative regulation of viral release from host cell uc009irw.1 uc009irw.2 uc009irw.3 uc009irw.4 
ENSMUST00000033267.4 Pdilt ENSMUST00000033267.4 protein disulfide isomerase-like, testis expressed (from RefSeq NM_027943.1) ENSMUST00000033267.1 ENSMUST00000033267.2 ENSMUST00000033267.3 NM_027943 PDILT_MOUSE Q9DAN1 uc009jld.1 uc009jld.2 uc009jld.3 Probable redox-inactive chaperone involved in spermatogenesis. Homodimer. The homodimer is not disulfide-linked. Interacts with CLGN and ERO1A (By similarity). Q9DAN1; Q62287: Adam3; NbExp=2; IntAct=EBI-15971896, EBI-15971963; Endoplasmic reticulum Testis-specific (at protein level). The thioredoxin domain lacks the conserved redox-active Cys at position 414 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity. N-glycosylated. Belongs to the protein disulfide isomerase family. Sequence=BAB24190.1; Type=Erroneous initiation; Evidence=; protein disulfide isomerase activity protein binding endoplasmic reticulum protein folding multicellular organism development spermatogenesis spermatid development cell migration isomerase activity cell differentiation cell redox homeostasis uc009jld.1 uc009jld.2 uc009jld.3 
ENSMUST00000033269.15 Ctbp2 ENSMUST00000033269.15 C-terminal binding protein 2, transcript variant 2 (from RefSeq NM_009980.5) Ctbp2 ENSMUST00000033269.1 ENSMUST00000033269.10 ENSMUST00000033269.11 ENSMUST00000033269.12 ENSMUST00000033269.13 ENSMUST00000033269.14 ENSMUST00000033269.2 ENSMUST00000033269.3 ENSMUST00000033269.4 ENSMUST00000033269.5 ENSMUST00000033269.6 ENSMUST00000033269.7 ENSMUST00000033269.8 ENSMUST00000033269.9 NM_009980 Q3UGL5 Q3UGL5_MOUSE uc009kcy.1 uc009kcy.2 uc009kcy.3 Nucleus Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor NAD binding oxidation-reduction process uc009kcy.1 uc009kcy.2 uc009kcy.3 
ENSMUST00000033275.4 Tex36 ENSMUST00000033275.4 testis expressed 36 (from RefSeq NM_028654.1) 4930404H21Rik ENSMUST00000033275.1 ENSMUST00000033275.2 ENSMUST00000033275.3 NM_028654 Q9D5N9 Q9D5N9_MOUSE Tex36 uc009kda.1 uc009kda.2 uc009kda.3 molecular_function cellular_component biological_process uc009kda.1 uc009kda.2 uc009kda.3 
ENSMUST00000033276.11 Uros ENSMUST00000033276.11 uroporphyrinogen III synthase, transcript variant 7 (from RefSeq NR_153416.1) ENSMUST00000033276.1 ENSMUST00000033276.10 ENSMUST00000033276.2 ENSMUST00000033276.3 ENSMUST00000033276.4 ENSMUST00000033276.5 ENSMUST00000033276.6 ENSMUST00000033276.7 ENSMUST00000033276.8 ENSMUST00000033276.9 NR_153416 Q3UG55 Q3UG55_MOUSE Uros uc009kdg.1 uc009kdg.2 uc009kdg.3 uc009kdg.4 The protein encoded by this gene is the fourth enzyme in the heme biosynthesis pathway. It converts hydroxymethylbilane to uroporphyrinogen III, a cyclic tetrapyrrole. This enzyme is defective in the autosomal recessive disorder congenital erythropoietic porphyria. Alternate promoter usage controls cell type-specific expression, including erythroid cell-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4. Belongs to the uroporphyrinogen-III synthase family. uroporphyrinogen-III synthase activity cytosol uroporphyrinogen III biosynthetic process heme biosynthetic process tetrapyrrole biosynthetic process response to antibiotic cofactor binding response to platinum ion cellular response to arsenic-containing substance cellular response to amine stimulus uc009kdg.1 uc009kdg.2 uc009kdg.3 uc009kdg.4 
ENSMUST00000033278.8 Mmp21 ENSMUST00000033278.8 matrix metallopeptidase 21, transcript variant 1 (from RefSeq NM_152944.1) ENSMUST00000033278.1 ENSMUST00000033278.2 ENSMUST00000033278.3 ENSMUST00000033278.4 ENSMUST00000033278.5 ENSMUST00000033278.6 ENSMUST00000033278.7 MMP21_MOUSE NM_152944 Q8K3F2 uc009kdd.1 uc009kdd.2 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. Mice harboring certain mutations in this gene exhibit congenital heart defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]. Plays a specialized role in the generation of left-right asymmetry during embryogenesis (PubMed:26437028). May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Secreted The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Belongs to the peptidase M10A family. hematopoietic progenitor cell differentiation metalloendopeptidase activity extracellular region extracellular space proteolysis determination of left/right symmetry peptidase activity metallopeptidase activity zinc ion binding hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix metal ion binding coronary vasculature development determination of heart left/right asymmetry uc009kdd.1 uc009kdd.2 
ENSMUST00000033282.5 Bccip ENSMUST00000033282.5 BRCA2 and CDKN1A interacting protein (from RefSeq NM_025392.2) BCCIP_MOUSE ENSMUST00000033282.1 ENSMUST00000033282.2 ENSMUST00000033282.3 ENSMUST00000033282.4 NM_025392 Q9CWI3 Q9D1E0 uc009kdi.1 uc009kdi.2 During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity). Interacts with BRCA2, CDKN1A and MTDH/LYRIC. Interacts with DCTN1/p150-glued and ACTR1A/ARP1. Interacts with alpha-, beta- and gamma-tubulins. Interacts with TENT5C; the interaction has no effect on TENT5C poly(A) polymerase function (By similarity). Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle pole Note=Colocalizes with BRCA2 in discrete nuclear foci (By similarity). In interphase, preferential localizes to the mother centriole (PubMed:28394342). Recruited to the spindle pole matrix and centrosome by microtubules and dynein/dynactin activity (By similarity). Expressed in the testes (at protein level). Belongs to the BCP1 family. regulation of cyclin-dependent protein serine/threonine kinase activity establishment of mitotic spindle orientation microtubule cytoskeleton organization spindle pole nucleus nucleoplasm cytoplasm centrosome centriole cytosol cytoskeleton DNA repair cellular response to DNA damage stimulus cell cycle mitotic spindle organization tubulin binding kinase regulator activity nuclear cyclin-dependent protein kinase holoenzyme complex microtubule anchoring neuroendocrine cell differentiation mitotic spindle assembly mitotic spindle pole uc009kdi.1 uc009kdi.2 
ENSMUST00000033283.10 Rrm1 ENSMUST00000033283.10 ribonucleotide reductase M1 (from RefSeq NM_009103.3) ENSMUST00000033283.1 ENSMUST00000033283.2 ENSMUST00000033283.3 ENSMUST00000033283.4 ENSMUST00000033283.5 ENSMUST00000033283.6 ENSMUST00000033283.7 ENSMUST00000033283.8 ENSMUST00000033283.9 NM_009103 P07742 Q91YM8 RIR1_MOUSE uc009irp.1 uc009irp.2 uc009irp.3 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Reaction=[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'- diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'- diphosphate; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57930, ChEBI:CHEBI:73316; EC=1.17.4.1; Evidence=; Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding to separate specificity and activation sites on the M1 subunit. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction. Stimulated by ATP and inhibited by dATP binding to the activity site, the dATP inhibition is mediated by AHCYL1 which stabilizes dATP in the site (By similarity). Heterodimer of a large and a small subunit. Interacts with RRM2B. Interacts with AHCYL1 which inhibits its activity (By similarity). Cytoplasm. Two distinct regulatory sites have been defined: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate- binding catalytic site, located on M1, is formed only in the presence of the second subunit M2. The level of the enzyme activity is closely correlated with the growth rate of a cell and appears to vary with the cell cycle. Belongs to the ribonucleoside diphosphate reductase large chain family. nucleotide binding mitotic cell cycle catalytic activity ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor protein binding ATP binding nuclear envelope cytoplasm cytosol ribonucleoside-diphosphate reductase complex pyrimidine nucleobase metabolic process DNA replication metabolic process male gonad development deoxyribonucleotide biosynthetic process response to ionizing radiation oxidoreductase activity purine nucleotide binding cell proliferation in forebrain identical protein binding cell projection neuronal cell body protein heterotetramerization oxidation-reduction process retina development in camera-type eye disordered domain specific binding uc009irp.1 uc009irp.2 uc009irp.3 
ENSMUST00000033289.6 Stim1 ENSMUST00000033289.6 stromal interaction molecule 1, transcript variant 1 (from RefSeq NM_009287.5) ENSMUST00000033289.1 ENSMUST00000033289.2 ENSMUST00000033289.3 ENSMUST00000033289.4 ENSMUST00000033289.5 NM_009287 P70302 Q8K1E1 STIM1_MOUSE Sim uc009irm.1 uc009irm.2 uc009irm.3 uc009irm.4 Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as a Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release- activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with STIMATE, leading to promote STIM1 conformational switch. Monomer in the presence of Ca(2+). It oligomerizes in absence of Ca(2+). Forms homooligomers and heterooligomers with STIM2. Interacts (via the transmembrane region and the SOAR/CAD domain) with SPPL3; the interaction promotes the binding of STIM1 to ORAI1. Interacts with ORAI1. Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends. Interacts with CRACR2A/EFCAB4B; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with CRACR2A/EFCAB4B and ORAI1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with SARAF, promoting a slow inactivation of STIM1-dependent SOCE activity, possibly by facilitating the deoligomerization of STIM1 (By similarity). Interacts with EFHB; the interaction takes place upon Ca(2+)-store depletion and inhibits the association with SARAF (By similarity). Interacts with ASPH. Interacts with SLC35G1; intracellular Ca(2+)-dependent. May interact with ATP1A1, ATP2A2, ATP2B1, ATP2B4, KPNB1 and XPO1; through SLC35G1. Interacts with TMEM203. Interacts with STIMATE, promoting STIM1 conformational switch (By similarity). Interacts with TMEM178A (PubMed:26644563). Interacts with CASQ1 (via C-terminal end and preferentially with the monomeric form); this interaction increases in response to a depletion of intracellular Ca(2+), decreases both STIM1 aggregation and clustering, interaction of STIM1 with ORAI1 and store-operated Ca(2+) entry (SOCE) activity (By similarity). Interacts with ADCY8 (By similarity). P70302; P70302: Stim1; NbExp=2; IntAct=EBI-8402335, EBI-8402335; Cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single- pass type I membrane protein Sarcoplasmic reticulum Cytoplasm, cytoskeleton Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular Ca(2+) and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules. Colocalizes with ORAI1 at the cell membrane. Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium (By similarity). Expressed in maturation-stage ameloblasts (at protein level). Expressed in all tissues examined and in many cell types, including bone marrow stroma, fibroblast, B-cell precursors, lymphoma and erythroleukemia. The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends. The STIM1 Orai1-activating region/CRAC-activating domain (SOAR/CAD) mediates interaction with ORAI1 to activate the channel. Glycosylation is required for cell surface expression. Phosphorylated predominantly on Ser residues. protease binding store-operated calcium entry calcium channel regulator activity calcium ion binding detection of calcium ion protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytoskeleton microtubule plasma membrane integral component of plasma membrane ion transport cation transport calcium ion transport cellular calcium ion homeostasis myotube differentiation store-operated calcium channel activity membrane integral component of membrane sarcoplasmic reticulum integral component of endoplasmic reticulum membrane growth cone activation of store-operated calcium channel activity cortical endoplasmic reticulum macromolecular complex sarcoplasmic reticulum membrane identical protein binding plasma membrane raft positive regulation of adenylate cyclase activity positive regulation of angiogenesis metal ion binding microtubule plus-end binding regulation of calcium ion transport enamel mineralization calcium ion transmembrane transport regulation of store-operated calcium entry uc009irm.1 uc009irm.2 uc009irm.3 uc009irm.4 
ENSMUST00000033300.4 Art1 ENSMUST00000033300.4 ADP-ribosyltransferase 1, transcript variant 1 (from RefSeq NM_009710.5) Art2 ENSMUST00000033300.1 ENSMUST00000033300.2 ENSMUST00000033300.3 NAR1_MOUSE NM_009710 P70688 Q60935 uc009iqu.1 uc009iqu.2 uc009iqu.3 Has ADP-ribosyltransferase activity toward GLP1R. Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D- ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=2.4.2.31; Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor. Abundantly expressed in cardiac and skeletal muscle. Low levels also found in lung. Belongs to the Arg-specific ADP-ribosyltransferase family. NAD+ ADP-ribosyltransferase activity NAD(P)+-protein-arginine ADP-ribosyltransferase activity protein ADP-ribosylation cell surface membrane sarcoplasmic reticulum transferase activity transferase activity, transferring glycosyl groups peptidyl-arginine ADP-ribosylation anchored component of membrane sarcoplasmic reticulum membrane uc009iqu.1 uc009iqu.2 uc009iqu.3 
ENSMUST00000033310.9 Mki67 ENSMUST00000033310.9 antigen identified by monoclonal antibody Ki 67 (from RefSeq NM_001081117.2) E9PVX6 ENSMUST00000033310.1 ENSMUST00000033310.2 ENSMUST00000033310.3 ENSMUST00000033310.4 ENSMUST00000033310.5 ENSMUST00000033310.6 ENSMUST00000033310.7 ENSMUST00000033310.8 KI67_MOUSE Mki67 NM_001081117 Q61769 Q7TSF6 uc009kem.1 uc009kem.2 uc009kem.3 uc009kem.4 Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (By similarity). Does not contribute to the internal structure of mitotic chromosomes (PubMed:26949251). May play a role in chromatin organization (PubMed:26949251). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed. Interacts with KIF15 (By similarity). Interacts (via the FHA domain) with NIFK (By similarity). Interacts with PPP1CC (By similarity). Component of a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5; the complex is formed as a result of interactions between components of a nuclear receptor- mediated transcription complex and a histone methylation complex (By similarity). Interacts with ZNF335 (By similarity). Chromosome cleus cleus, nucleolus Note=Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:8834799, PubMed:12355204). Associates with satellite DNA in G1 phase (By similarity). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (By similarity). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9PVX6-1; Sequence=Displayed; Name=2; IsoId=E9PVX6-2; Sequence=VSP_058551; Mainly present in proliferating cells (at protein level). Accumulates during the late G1 stage in the nucleus and maximum expression is found during G2 phase and mitosis (PubMed:8834799). During male meiosis, present in nuclei of all stages from the spermatogonium through spermatocytes I and II up to the earliest spermatid stage (early round spermatids) and then fades out (PubMed:12355204). Not detected in later spermatid stages or sperm (PubMed:12355204). During female meiosis, present in prophase I oocytes of fetal ovaries, while it is absent in resting oocytes. Reappears in oocytes of growing follicles and is continuously present up to metaphase II (at protein level) (PubMed:12355204). Phosphorylated. Hyperphosphorylated in mitosis. Hyperphosphorylated form does not bind DNA. No visible phenotype. Mice were born at the expected Mendelian ratio and show no overt phenotype (PubMed:26949251). Cells do not show proliferation defects, but chromatin organization is impaired, with defects in heterochromatin compaction and long-range genomic interactions (PubMed:26949251). Was thought to play a key role in cell proliferation, and is commonly used as a marker of cell proliferation. However, its primary function is uncoupled from cell proliferation (PubMed:26949251). Required to maintain mitotic chromosomes dispersed by forming a steric and electrostatic charge barrier (PubMed:27362226). Sequence=AAH53453.1; Type=Frameshift; Evidence=; Sequence=CAA58026.1; Type=Frameshift; Evidence=; Name=Protein Spotlight; Note=The contours of heredity - Issue 186 of December 2016; URL="https://web.expasy.org/spotlight/back_issues/186/"; nucleotide binding chromosome, centromeric region condensed chromosome DNA binding ATP binding nucleus chromosome nucleolus cytoplasm cell cycle regulation of mitotic nuclear division protein C-terminus binding cell proliferation nuclear body meiotic cell cycle regulation of chromosome segregation hepatocyte proliferation regulation of chromatin organization cholangiocyte proliferation uc009kem.1 uc009kem.2 uc009kem.3 uc009kem.4 
ENSMUST00000033313.3 Atp6ap2 ENSMUST00000033313.3 ATPase, H+ transporting, lysosomal accessory protein 2 (from RefSeq NM_027439.4) A2BDN5 Atp6ap2 Atp6ip2 ENSMUST00000033313.1 ENSMUST00000033313.2 NM_027439 Q8BVU6 Q91YU5 Q9CYN9 RENR_MOUSE uc009sqx.1 uc009sqx.2 uc009sqx.3 uc009sqx.4 Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system (By similarity). May mediate renin-dependent cellular responses by activating ERK1 and ERK2 (By similarity). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin- angiotensin system (RAS) (By similarity). Through its function in V- type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (PubMed:26376863, PubMed:29127204, PubMed:30985297). Interacts with renin. Accessory component of the multisubunit proton-transporting vacuolar (V)-ATPase protein pump. Interacts (via N- terminus) with ATP6AP1 (via N-terminus). Interacts with ATP6V0D1; ATP6V0D1 is a V-ATPase complex subunit and the interaction promotes V- ATPase complex assembly. Interacts with TMEM9; TMEM9 is a V-ATPase assembly regulator and the interaction induces the interaction with ATP6V0D1. Interacts with VMA21 (via N-terminus); VMA21 is a V-ATPase accessory component. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Lysosome membrane ingle-pass type I membrane protein Cytoplasmic vesicle, autophagosome membrane ; Single-pass type I membrane protein Cell projection, dendritic spine membrane ; Single-pass type I membrane protein Cell projection, axon Endosome membrane ; Single-pass type I membrane protein Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Single-pass type I membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein Expressed in glutamatergic and GABAergic neurons with highest levels in the cortex, the hippocampus, the medial habenular nucleus, the cerebellum, the medulla and the olfactory bulb (at protein level). Expressed at 12 dpc throughout the developing cortex with notable apical enrichment in radial glial cells (RGCs) along the ventricular surface. Phosphorylated. Proteolytically cleaved by a furin-like convertase in the trans- Golgi network to generate N- and C-terminal fragments. Conditional knockout mice lacking Atp6ap2 in glutamatergic neurons display increased spontaneous locomotor activity and altered fear memory; show abnormal number and morphology of synapses, presynaptic transmission and autophagy defects that lead to axonal and neuronal degeneration in the cortex and hippocampus (PubMed:26376863). Conditional knockout mice lacking Atp6ap2 in the liver display liver damage, hypoglycosylation of serum proteins and autophagy defects (PubMed:29127204, PubMed:26376863). Conditional knockout mice lacking Atp6ap2 in cortical neurons die around 4 weeks of age (PubMed:30985297). It is associated with a flattened forehead and deficits in neural cell generation and/or survival compared to controls. Mutant embryonic cortex shows reduced proliferation of progenitor neural cells with premature exit of the cell cycle, premature differentiation, and apoptosis. There is also evidence of lysosomal dysfunction, impaired protein degradation in autophagolysosomes, and dysregulation of the mTOR kinase pathway. angiotensin maturation extracellular space lysosome endoplasmic reticulum membrane external side of plasma membrane membrane integral component of membrane apical plasma membrane vacuolar proton-transporting V-type ATPase complex rostrocaudal neural tube patterning positive regulation of Wnt signaling pathway positive regulation of transforming growth factor beta1 production signaling receptor activity neuron projection regulation of MAPK cascade cell body eye pigmentation head morphogenesis uc009sqx.1 uc009sqx.2 uc009sqx.3 uc009sqx.4 
ENSMUST00000033325.9 Swap70 ENSMUST00000033325.9 SWA-70 protein, transcript variant 1 (from RefSeq NM_009302.4) ENSMUST00000033325.1 ENSMUST00000033325.2 ENSMUST00000033325.3 ENSMUST00000033325.4 ENSMUST00000033325.5 ENSMUST00000033325.6 ENSMUST00000033325.7 ENSMUST00000033325.8 Kiaa0640 NM_009302 O88443 Q3TQR6 Q3UCA3 Q6A028 Q6P1D0 SWP70_MOUSE uc009jfb.1 uc009jfb.2 uc009jfb.3 uc009jfb.4 Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Q6A028; Q61738-6: Itga7; NbExp=2; IntAct=EBI-2121215, EBI-1786329; Cytoplasm Cell membrane Nucleus Cell projection, lamellipodium Cytoplasm, cytoskeleton Note=Localizes predominantly to the nucleus in activated cells. Only a small amount can be detected in the cytoplasm. Spleen. Expressed only in B-cells that have been induced to switch to various Ig isotypes. Not detected in the spleen of 1-week old mice. Detected from 2-weeks onwards and thereafter levels increase and then from 12-weeks onwards levels decline. The PH domain is essential for phosphatidylinositol 3,4,5- trisphosphate binding. Tyrosine-phosphorylated. Sequence=BAD32268.1; Type=Erroneous initiation; Evidence=; DNA binding protein binding ATP binding nucleus cytoplasm cytoskeleton plasma membrane positive regulation of cytosolic calcium ion concentration regulation of actin polymerization or depolymerization membrane somatic cell DNA recombination lamellipodium negative regulation of actin filament depolymerization positive regulation of actin filament bundle assembly regulation of protein localization negative regulation of cell-cell adhesion mediated by integrin cell projection isotype switching actin filament bundle assembly positive regulation of mast cell chemotaxis negative regulation of peptidyl-serine dephosphorylation uc009jfb.1 uc009jfb.2 uc009jfb.3 uc009jfb.4 
ENSMUST00000033326.10 Wee1 ENSMUST00000033326.10 WEE 1 homolog 1 (S. pombe), transcript variant 1 (from RefSeq NM_009516.3) ENSMUST00000033326.1 ENSMUST00000033326.2 ENSMUST00000033326.3 ENSMUST00000033326.4 ENSMUST00000033326.5 ENSMUST00000033326.6 ENSMUST00000033326.7 ENSMUST00000033326.8 ENSMUST00000033326.9 NM_009516 P47810 Q9EPL7 WEE1_MOUSE uc009jey.1 uc009jey.2 uc009jey.3 Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions per subunit. ; Synthesis is increased during S and G2 phases, presumably by an increase in transcription; activity is decreased by phosphorylation during m phase. Protein levels fall in M phase as a result of decreased synthesis combined with degradation. Activity seems to be negatively regulated by phosphorylation upon entry into mitosis, although N-terminal phosphorylation might also regulate the protein stability via protection from proteolysis or might regulate the subcellular location (By similarity). Binds to 14-3-3 protein zeta. Nucleus Phosphorylated during M and G1 phases. Also autophosphorylated. Phosphorylation at Ser-642 by BRSK1 and BRSK2 in post-mitotic neurons, leads to down-regulate WEE1 activity in polarized neurons. Phosphorylated at Ser-52 and Ser-123 by PLK1 and CDK1, respectively, generating an signal for degradation that can be recognized by the SCF(BTRC) complex, leading to its ubiquitination and degradation at the onset of G2/M phase (By similarity). Dephosphorylated at Thr-239 by CTDP1 (By similarity). Dephosphorylated at Ser-52 and Ser-123 by the serine/threonine-protein phosphatase 2A preventing its ubiquitin-mediated degradation (By similarity). Ubiquitinated and degraded at the onset of G2/M phase. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle magnesium ion binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding nucleus nucleoplasm nucleolus cytoplasm protein phosphorylation cell cycle mitotic cell cycle checkpoint kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation establishment of cell polarity metal ion binding neuron projection morphogenesis cell division uc009jey.1 uc009jey.2 uc009jey.3 
ENSMUST00000033331.7 Nrip3 ENSMUST00000033331.7 nuclear receptor interacting protein 3 (from RefSeq NM_020610.1) D7H11orf14 ENSMUST00000033331.1 ENSMUST00000033331.2 ENSMUST00000033331.3 ENSMUST00000033331.4 ENSMUST00000033331.5 ENSMUST00000033331.6 NM_020610 NRIP3_MOUSE Q8BUN8 Q9JJR9 uc009jef.1 uc009jef.2 uc009jef.3 aspartic-type endopeptidase activity cellular_component proteolysis biological_process uc009jef.1 uc009jef.2 uc009jef.3 
ENSMUST00000033333.13 Tmem9b ENSMUST00000033333.13 TMEM9 domain family, member B (from RefSeq NM_020050.1) ENSMUST00000033333.1 ENSMUST00000033333.10 ENSMUST00000033333.11 ENSMUST00000033333.12 ENSMUST00000033333.2 ENSMUST00000033333.3 ENSMUST00000033333.4 ENSMUST00000033333.5 ENSMUST00000033333.6 ENSMUST00000033333.7 ENSMUST00000033333.8 ENSMUST00000033333.9 NM_020050 Q9JJR8 TMM9B_MOUSE uc009jec.1 uc009jec.2 uc009jec.3 Enhances production of pro-inflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways. Lysosome membrane ; Single-pass membrane protein Early endosome membrane ; Single-pass membrane protein N-glycosylated. Belongs to the TMEM9 family. cellular_component lysosome lysosomal membrane endosome membrane integral component of membrane early endosome membrane uc009jec.1 uc009jec.2 uc009jec.3 
ENSMUST00000033334.5 BC051019 ENSMUST00000033334.5 Sequence=CAB92297.1; Type=Erroneous gene model prediction; Evidence=; (from UniProt Q9JJR6) AK143006 CK016_MOUSE D7h11orf16 ENSMUST00000033334.1 ENSMUST00000033334.2 ENSMUST00000033334.3 ENSMUST00000033334.4 Q80XE7 Q9JJR6 uc009jea.1 uc009jea.2 uc009jea.3 Sequence=CAB92297.1; Type=Erroneous gene model prediction; Evidence=; molecular_function cellular_component biological_process uc009jea.1 uc009jea.2 uc009jea.3 
ENSMUST00000033335.6 Akip1 ENSMUST00000033335.6 A kinase interacting protein 1 (from RefSeq NM_020616.2) AKIP1_MOUSE Bca3 ENSMUST00000033335.1 ENSMUST00000033335.2 ENSMUST00000033335.3 ENSMUST00000033335.4 ENSMUST00000033335.5 NM_020616 Q3TR76 Q9JJR5 uc009jdy.1 uc009jdy.2 uc009jdy.3 Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). Interacts with PRKACA and RELA. Nucleus Note=Locates to punctate spots. protein binding nucleus nucleoplasm substrate adhesion-dependent cell spreading perinuclear region of cytoplasm regulation of NIK/NF-kappaB signaling uc009jdy.1 uc009jdy.2 uc009jdy.3 
ENSMUST00000033341.12 Tub ENSMUST00000033341.12 TUB bipartite transcription factor (from RefSeq NM_021885.4) ENSMUST00000033341.1 ENSMUST00000033341.10 ENSMUST00000033341.11 ENSMUST00000033341.2 ENSMUST00000033341.3 ENSMUST00000033341.4 ENSMUST00000033341.5 ENSMUST00000033341.6 ENSMUST00000033341.7 ENSMUST00000033341.8 ENSMUST00000033341.9 NM_021885 Q4VA41 Q4VA41_MOUSE Tub uc009jdf.1 uc009jdf.2 uc009jdf.3 Secreted Belongs to the TUB family. G-protein coupled receptor binding nucleus cytoplasm cilium response to hormone intraciliary transport macromolecular complex binding positive regulation of phagocytosis uc009jdf.1 uc009jdf.2 uc009jdf.3 
ENSMUST00000033342.7 Eif3f ENSMUST00000033342.7 eukaryotic translation initiation factor 3, subunit F (from RefSeq NM_025344.2) EIF3F_MOUSE ENSMUST00000033342.1 ENSMUST00000033342.2 ENSMUST00000033342.3 ENSMUST00000033342.4 ENSMUST00000033342.5 ENSMUST00000033342.6 Eif3s5 NM_025344 Q5XJV3 Q9DCH4 uc009jdc.1 uc009jdc.2 uc009jdc.3 uc009jdc.4 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner. Interacts with DTX1, the interaction is required for deubiquitinating activity towards NOTCH1 (By similarity). Q9DCH4; Q9JLN9: Mtor; NbExp=5; IntAct=EBI-1634316, EBI-1571628; Q9DCH4; Q86Y01: DTX1; Xeno; NbExp=9; IntAct=EBI-1634316, EBI-1755174; Q9DCH4; Q14152: EIF3A; Xeno; NbExp=4; IntAct=EBI-1634316, EBI-366617; Cytoplasm The MPN domain mediates deubiquitinating activity. Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK11 (By similarity). Belongs to the eIF-3 subunit F family. formation of cytoplasmic translation initiation complex cytoplasmic translational initiation translation initiation factor activity thiol-dependent ubiquitin-specific protease activity protein binding cytoplasm eukaryotic translation initiation factor 3 complex translation translational initiation proteolysis peptidase activity cysteine-type peptidase activity eukaryotic 43S preinitiation complex protein deubiquitination hydrolase activity translation initiation factor binding eukaryotic 48S preinitiation complex thiol-dependent ubiquitinyl hydrolase activity eukaryotic translation initiation factor 3 complex, eIF3m IRES-dependent viral translational initiation uc009jdc.1 uc009jdc.2 uc009jdc.3 uc009jdc.4 
ENSMUST00000033380.7 Cdk16 ENSMUST00000033380.7 cyclin dependent kinase 16, transcript variant 1 (from RefSeq NM_011049.6) Cdk16 ENSMUST00000033380.1 ENSMUST00000033380.2 ENSMUST00000033380.3 ENSMUST00000033380.4 ENSMUST00000033380.5 ENSMUST00000033380.6 NM_011049 Pctk1 Q543G3 Q543G3_MOUSE uc009sto.1 uc009sto.2 uc009sto.3 uc009sto.4 uc009sto.5 Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm cytosol plasma membrane protein phosphorylation microtubule cytoskeleton kinase activity phosphorylation extrinsic component of cytoplasmic side of plasma membrane regulation of insulin secretion involved in cellular response to glucose stimulus uc009sto.1 uc009sto.2 uc009sto.3 uc009sto.4 uc009sto.5 
ENSMUST00000033383.3 Usp11 ENSMUST00000033383.3 ubiquitin specific peptidase 11, transcript variant 1 (from RefSeq NM_145628.4) B1AXB2 ENSMUST00000033383.1 ENSMUST00000033383.2 NM_145628 Q3TLG5 Q99K46 UBP11_MOUSE uc009stq.1 uc009stq.2 uc009stq.3 uc009stq.4 uc009stq.5 Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys- 63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys- 33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex. Promotes cell proliferation by deubiquitinating phosphorylated E2F1. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Monomer (By similarity). Associated component of the Polycomb group (PcG) multiprotein PRC1-like complex (By similarity). Interacts with RANBP9/RANBPM (By similarity). Interacts with BRCA2 (By similarity). Interacts with CHUK/IKKA (By similarity). Interacts with NFKBIA (By similarity). Interacts with SPRY3, RAE1, MYCBP2/PAM, and KCTD6 (By similarity). Nucleus Cytoplasm Chromosome Note=Predominantly nuclear. Associates with chromatin. Belongs to the peptidase C19 family. Sequence=AAH05470.1; Type=Erroneous initiation; Evidence=; thiol-dependent ubiquitin-specific protease activity nucleus nucleoplasm chromosome cytoplasm cytosol proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity uc009stq.1 uc009stq.2 uc009stq.3 uc009stq.4 uc009stq.5 
ENSMUST00000033386.12 Mrgprf ENSMUST00000033386.12 MAS-related GPR, member F (from RefSeq NM_145379.2) ENSMUST00000033386.1 ENSMUST00000033386.10 ENSMUST00000033386.11 ENSMUST00000033386.2 ENSMUST00000033386.3 ENSMUST00000033386.4 ENSMUST00000033386.5 ENSMUST00000033386.6 ENSMUST00000033386.7 ENSMUST00000033386.8 ENSMUST00000033386.9 MRGRF_MOUSE Mrgf NM_145379 Q8VCJ6 Q91ZB6 uc009kqz.1 uc009kqz.2 uc009kqz.3 Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Mas subfamily. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane nuclear membrane uc009kqz.1 uc009kqz.2 uc009kqz.3 
ENSMUST00000033388.13 LTO1 ENSMUST00000033388.13 ABCE maturation factor, transcript variant 2 (from RefSeq NM_028184.5) ENSMUST00000033388.1 ENSMUST00000033388.10 ENSMUST00000033388.11 ENSMUST00000033388.12 ENSMUST00000033388.2 ENSMUST00000033388.3 ENSMUST00000033388.4 ENSMUST00000033388.5 ENSMUST00000033388.6 ENSMUST00000033388.7 ENSMUST00000033388.8 ENSMUST00000033388.9 LTO1_MOUSE Lto1 NM_028184 Oraov1 Q8CH62 Q91YY7 Q922P0 Q9D7Y4 uc009kqs.1 uc009kqs.2 uc009kqs.3 uc009kqs.4 The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation. May play a role in the regulation of proline metabolism and ROS production. Forms a complex with YAE1. Interacts with PYCR1 and PYCR2. Nucleus Belongs to the LTO1 family. Sequence=AAH13564.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB25842.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC38828.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; telomere maintenance molecular_function nucleus translational initiation ribosomal large subunit biogenesis uc009kqs.1 uc009kqs.2 uc009kqs.3 uc009kqs.4 
ENSMUST00000033389.7 Fgf15 ENSMUST00000033389.7 fibroblast growth factor 15 (from RefSeq NM_008003.2) ENSMUST00000033389.1 ENSMUST00000033389.2 ENSMUST00000033389.3 ENSMUST00000033389.4 ENSMUST00000033389.5 ENSMUST00000033389.6 Fgf15 Fgf8a NM_008003 Q790L8 Q790L8_MOUSE uc009kqr.1 uc009kqr.2 uc009kqr.3 uc009kqr.4 Belongs to the heparin-binding growth factors family. positive regulation of protein phosphorylation fibroblast growth factor receptor binding extracellular region growth factor activity positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway negative regulation of gene expression positive regulation of glucose import positive regulation of JNK cascade positive regulation of ERK1 and ERK2 cascade negative regulation of bile acid biosynthetic process uc009kqr.1 uc009kqr.2 uc009kqr.3 uc009kqr.4 
ENSMUST00000033394.8 Fadd ENSMUST00000033394.8 Fas associated via death domain (from RefSeq NM_010175.6) ENSMUST00000033394.1 ENSMUST00000033394.2 ENSMUST00000033394.3 ENSMUST00000033394.4 ENSMUST00000033394.5 ENSMUST00000033394.6 ENSMUST00000033394.7 FADD_MOUSE Fadd Mort1 NM_010175 Q3TC37 Q61082 Q61160 uc009kql.1 uc009kql.2 uc009kql.3 Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. Can self-associate (By similarity). Interacts with CFLAR, PEA15 and MBD4 (By similarity). When phosphorylated, part of a complex containing HIPK3 and FAS (By similarity). May interact with MAVS/IPS1 (By similarity). Interacts with MOCV v-CFLAR protein and PIDD1 (By similarity). Interacts (via death domain) with FAS (via death domain) (By similarity). Interacts with CASP8 (PubMed:29440439). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death- inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (PubMed:15383280). Interacts with RIPK1, TRADD and CASP8 (PubMed:28842570, PubMed:29440439, PubMed:30185824, PubMed:31519887). Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis) (PubMed:34471287). Interacts with stimulated TNFRSF10B (By similarity). Q61160; O89110: Casp8; NbExp=6; IntAct=EBI-524415, EBI-851690; Q61160; P25446: Fas; NbExp=3; IntAct=EBI-524415, EBI-296206; Q61160; Q60855: Ripk1; NbExp=9; IntAct=EBI-524415, EBI-529119; Q61160; Q9QZL0: Ripk3; NbExp=6; IntAct=EBI-524415, EBI-2367423; Contains a death domain involved in the binding of the corresponding domain within Fas receptor. The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC). kidney development positive regulation of T cell mediated cytotoxicity protease binding immune system process positive regulation of adaptive immune response death receptor binding tumor necrosis factor receptor binding protein binding nucleus cytoplasm cytosol plasma membrane apoptotic process signal transduction T cell differentiation death-inducing signaling complex CD95 death-inducing signaling complex positive regulation of interferon-gamma production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production tumor necrosis factor receptor superfamily binding macromolecular complex T cell differentiation in thymus receptor serine/threonine kinase binding death effector domain binding TRAIL-activated apoptotic signaling pathway positive regulation of activated T cell proliferation response to cocaine identical protein binding regulation of apoptotic process neuron projection T cell homeostasis positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling response to morphine cell body macromolecular complex binding innate immune response membrane raft positive regulation of macrophage differentiation positive regulation of proteolysis positive regulation of transcription from RNA polymerase II promoter behavioral response to cocaine lymph node development spleen development thymus development cardiac muscle tissue development defense response to virus positive regulation of type I interferon-mediated signaling pathway regulation of necroptotic process negative regulation of necroptotic process negative regulation of activation-induced cell death of T cells cellular response to mechanical stimulus caspase binding motor neuron apoptotic process apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand activation of cysteine-type endopeptidase activity ripoptosome necroptotic signaling pathway positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation positive regulation of extrinsic apoptotic signaling pathway uc009kql.1 uc009kql.2 uc009kql.3 
ENSMUST00000033414.8 Slc6a14 ENSMUST00000033414.8 solute carrier family 6 (neurotransmitter transporter), member 14 (from RefSeq NM_020049.4) ENSMUST00000033414.1 ENSMUST00000033414.2 ENSMUST00000033414.3 ENSMUST00000033414.4 ENSMUST00000033414.5 ENSMUST00000033414.6 ENSMUST00000033414.7 NM_020049 Q91Y60 Q9D317 Q9JMA9 Q9R183 S6A14_MOUSE Slc6a14 uc009sur.1 uc009sur.2 uc009sur.3 uc009sur.4 uc009sur.5 Amino acid transporter that plays an important role in the absorption of amino acids in the intestinal tract. Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner (PubMed:11306607, PubMed:11447016). Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (By similarity). Can also transport carnitine, butyrylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:11306651). Reaction=chloride(out) + glycine(out) + 2 Na(+)(out) = chloride(in) + glycine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70691, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57305; Evidence=; Reaction=chloride(out) + L-leucine(out) + 2 Na(+)(out) = chloride(in) + L-leucine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71279, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57427; Evidence=; Reaction=chloride(out) + L-glutamine(out) + 2 Na(+)(out) = chloride(in) + L-glutamine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71283, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:58359; Evidence=; Reaction=chloride(out) + L-arginine(out) + 2 Na(+)(out) = chloride(in) + L-arginine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71287, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:32682; Evidence=; Reaction=(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) = (R)- carnitine(in) + chloride(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71291, ChEBI:CHEBI:16347, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101; Evidence=; Reaction=chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) = chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in); Xref=Rhea:RHEA:71295, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:53210; Evidence=; Reaction=chloride(out) + L-isoleucine(out) + 2 Na(+)(out) = chloride(in) + L-isoleucine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71299, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:58045; Evidence=; Reaction=chloride(out) + L-methionine(out) + 2 Na(+)(out) = chloride(in) + L-methionine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71303, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57844; Evidence=; Reaction=chloride(out) + L-valine(out) + 2 Na(+)(out) = chloride(in) + L-valine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71307, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57762; Evidence=; Reaction=chloride(out) + L-alanine(out) + 2 Na(+)(out) = chloride(in) + L-alanine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71311, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57972; Evidence=; Reaction=chloride(out) + L-serine(out) + 2 Na(+)(out) = chloride(in) + L-serine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71315, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384; Evidence=; Reaction=chloride(out) + L-cysteine(out) + 2 Na(+)(out) = chloride(in) + L-cysteine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71319, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:35235; Evidence=; Reaction=chloride(out) + L-asparagine(out) + 2 Na(+)(out) = chloride(in) + L-asparagine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71323, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:58048; Evidence=; Reaction=chloride(out) + L-threonine(out) + 2 Na(+)(out) = chloride(in) + L-threonine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71327, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57926; Evidence=; Reaction=chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) = chloride(in) + L-phenylalanine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71331, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:58095; Evidence=; Reaction=chloride(out) + L-tryptophan(out) + 2 Na(+)(out) = chloride(in) + L-tryptophan(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71335, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57912; Evidence=; Reaction=chloride(out) + L-tyrosine(out) + 2 Na(+)(out) = chloride(in) + L-tyrosine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71339, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:58315; Evidence=; Reaction=chloride(out) + L-histidine(out) + 2 Na(+)(out) = chloride(in) + L-histidine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71343, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57595; Evidence=; Reaction=chloride(out) + L-lysine(out) + 2 Na(+)(out) = chloride(in) + L-lysine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71347, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:32551; Evidence=; Reaction=chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out) = chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in); Xref=Rhea:RHEA:72163, ChEBI:CHEBI:17996, ChEBI:CHEBI:21949, ChEBI:CHEBI:29101; Evidence=; Membrane ; Multi- pass membrane protein Apical cell membrane ; Multi-pass membrane protein Expressed in the distal region of the intestinal tract: cecum and colon. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A14 subfamily. amine transmembrane transporter activity neurotransmitter:sodium symporter activity plasma membrane integral component of plasma membrane neurotransmitter transport amino acid transport response to toxic substance symporter activity amine transport membrane integral component of membrane brush border membrane transmembrane transport uc009sur.1 uc009sur.2 uc009sur.3 uc009sur.4 uc009sur.5 
ENSMUST00000033415.15 Nadsyn1 ENSMUST00000033415.15 NAD synthetase 1, transcript variant 1 (from RefSeq NM_030221.2) ENSMUST00000033415.1 ENSMUST00000033415.10 ENSMUST00000033415.11 ENSMUST00000033415.12 ENSMUST00000033415.13 ENSMUST00000033415.14 ENSMUST00000033415.2 ENSMUST00000033415.3 ENSMUST00000033415.4 ENSMUST00000033415.5 ENSMUST00000033415.6 ENSMUST00000033415.7 ENSMUST00000033415.8 ENSMUST00000033415.9 NADE_MOUSE NM_030221 Q711P6 Q711T7 Q8CFY6 Q9D280 uc009kqa.1 uc009kqa.2 uc009kqa.3 uc009kqa.4 Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source. Reaction=ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+); Xref=Rhea:RHEA:24384, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57540, ChEBI:CHEBI:58359, ChEBI:CHEBI:58437, ChEBI:CHEBI:456215; EC=6.3.5.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24385; Evidence=; Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1. Homohexamer. Highly expressed in small intestine, kidney, liver and testis. Weakly expressed in skeletal muscle, spleen, lung, heart and brain. In the C-terminal section; belongs to the NAD synthetase family. Sequence=CAC88023.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding NAD+ synthase (glutamine-hydrolyzing) activity glutaminase activity ATP binding cytoplasm cytosol nitrogen compound metabolic process NAD+ synthase activity NAD biosynthetic process ligase activity uc009kqa.1 uc009kqa.2 uc009kqa.3 uc009kqa.4 
ENSMUST00000033418.8 Il13ra1 ENSMUST00000033418.8 interleukin 13 receptor, alpha 1 (from RefSeq NM_133990.5) ENSMUST00000033418.1 ENSMUST00000033418.2 ENSMUST00000033418.3 ENSMUST00000033418.4 ENSMUST00000033418.5 ENSMUST00000033418.6 ENSMUST00000033418.7 I13R1_MOUSE Il13r Il13ra NM_133990 O09030 Q7TT27 uc009sxj.1 uc009sxj.2 uc009sxj.3 uc009sxj.4 uc009sxj.5 This gene encodes a transmembrane protein that complexes with interleukin 4 receptor alpha (IL4RA) to form a functional receptor for interleukin-13. Signalling through this pathway mediates allergy response and occurs during bronchial asthma. [provided by RefSeq, May 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052425.1, AK154675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity (By similarity). Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1 (By similarity). Interacts with IL4 (By similarity). Membrane; Single-pass type I membrane protein. Spleen, liver, thymus, heart, lung, kidney, testis, stomach, brain, skin, and colon; but not skeletal muscle. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Belongs to the type I cytokine receptor family. Type 5 subfamily. cytokine receptor activity external side of plasma membrane membrane integral component of membrane interleukin-13 receptor activity cytokine-mediated signaling pathway cytokine binding interleukin-2 binding interleukin-13-mediated signaling pathway receptor complex uc009sxj.1 uc009sxj.2 uc009sxj.3 uc009sxj.4 uc009sxj.5 
ENSMUST00000033419.13 Dock11 ENSMUST00000033419.13 dedicator of cytokinesis 11 (from RefSeq NM_001009947.3) A2AF47 DOC11_MOUSE Dock11 ENSMUST00000033419.1 ENSMUST00000033419.10 ENSMUST00000033419.11 ENSMUST00000033419.12 ENSMUST00000033419.2 ENSMUST00000033419.3 ENSMUST00000033419.4 ENSMUST00000033419.5 ENSMUST00000033419.6 ENSMUST00000033419.7 ENSMUST00000033419.8 ENSMUST00000033419.9 NM_001009947 Q5KTP7 Ziz2 uc009sxi.1 uc009sxi.2 Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:15710388, PubMed:16968698, PubMed:25851601). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (PubMed:25729399). Facilitates filopodia formation through the activation of CDC42 (PubMed:22494997). Interacts with CDC42. Expressed in spleen, thymus, mesenteric lymph nodes (MLN), bone marrow and peripheral blood lymphocytes. Enriched in B- cells from germinal centers. Expressed in B-, T- and dendritic cells as well as Purkinje cells (PubMed:22494997, PubMed:25851601). In spleen, expression is down-regulated in aged mice. In dendritic cells, the expression is up-regulated by LPS and anti-Fc-gamma receptor. The DOCKER domain is necessary for the GEF activity (PubMed:25851601, PubMed:15710388). The DOCKER domain mediates interaction with activated CDC42 in conjunction with residues 66-126 (PubMed:16968698). Knockout mice are viable and fertile (PubMed:25729399). They have higher percentage of early bone marrow B- cells, but a reduced fraction of marginal zone B-cells. Their percentage of thymic CD4(+) T-cells is increased and they show an altered of morphologymarginal metallophilic macrophages (PubMed:25729399). 'Zizim' means 'spike' in Hebrew. Belongs to the DOCK family. B cell homeostasis marginal zone B cell differentiation guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cellular_component small GTPase mediated signal transduction Rho GTPase binding positive regulation of GTPase activity positive regulation of filopodium assembly uc009sxi.1 uc009sxi.2 
ENSMUST00000033427.7 Sash3 ENSMUST00000033427.7 SAM and SH3 domain containing 3, transcript variant 2 (from RefSeq NM_028773.4) ENSMUST00000033427.1 ENSMUST00000033427.2 ENSMUST00000033427.3 ENSMUST00000033427.4 ENSMUST00000033427.5 ENSMUST00000033427.6 NM_028773 Q3TBX0 Q8K352 Q9DBV2 SASH3_MOUSE Sly uc009tbw.1 uc009tbw.2 uc009tbw.3 uc009tbw.4 May function as a signaling adapter protein in lymphocytes. Preferentially expressed in lymphoid tissues. Expressed in bone marrow, thymus, spleen, lymph nodes and Peyer patches of gut. In the spleen and lymph nodes, expressed in both T- and B- cells. In the thymus, in the medulla and cortex. positive regulation of immunoglobulin production positive regulation of T cell cytokine production positive regulation of adaptive immune response nucleus cytoplasm positive regulation of B cell proliferation positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-2 production positive regulation of interleukin-4 production positive regulation of tumor necrosis factor production positive regulation of T cell proliferation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of organ growth homeostasis of number of cells within a tissue positive regulation of lymphocyte activation uc009tbw.1 uc009tbw.2 uc009tbw.3 uc009tbw.4 
ENSMUST00000033429.9 Elf4 ENSMUST00000033429.9 E74 like ETS transcription factor 4, transcript variant 2 (from RefSeq NM_019680.2) B1AY67 ELF4_MOUSE ENSMUST00000033429.1 ENSMUST00000033429.2 ENSMUST00000033429.3 ENSMUST00000033429.4 ENSMUST00000033429.5 ENSMUST00000033429.6 ENSMUST00000033429.7 ENSMUST00000033429.8 Elf4 Mef NM_019680 Q9Z2U4 uc012hgs.1 uc012hgs.2 Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of LYZ. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Transactivates the PRF1 promoter in natural killer (NK) cells and in CD8+ T cells (PubMed:34326534). Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel- like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN (PubMed:34326534, PubMed:35266071). Is a negative regulator of pro-inflammatory cytokines expression, including IL17A, IL1B, IL6, TNFA and CXCL1 (PubMed:34326534, PubMed:35266071). Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses (PubMed:34326534, PubMed:35266071). Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ (By similarity). Nucleus, PML body Note=Accumulation into PML nuclear bodies is mediated by PML. Belongs to the ETS family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding natural killer cell proliferation NK T cell proliferation DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nuclear body PML body cell differentiation sequence-specific DNA binding innate immune response positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc012hgs.1 uc012hgs.2 
ENSMUST00000033430.3 Rab33a ENSMUST00000033430.3 RAB33A, member RAS oncogene family, transcript variant 1 (from RefSeq NM_011228.3) ENSMUST00000033430.1 ENSMUST00000033430.2 NM_011228 Q3SXA7 Q3SXA7_MOUSE Rab33A Rab33a uc009tci.1 uc009tci.2 uc009tci.3 uc009tci.4 This gene encodes a member of the Ras-related small GTPases, which regulate membrane trafficking in organelles and transport vesicles. This protein has been reported to be expressed in lymphocytes and in regions of the mouse brain, specifically the cortex, hippocampus and also the olfactory bulb. The ortholog of this protein in rat has been characterized and may participate in anterograde trafficking of synaptophysin-positive vesicles to the plasma membrane. [provided by RefSeq, Jun 2013]. ##Evidence-Data-START## Transcript exon combination :: BU922072.1, D83279.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding antigen processing and presentation Rab protein signal transduction uc009tci.1 uc009tci.2 uc009tci.3 uc009tci.4 
ENSMUST00000033433.3 Rbmx2 ENSMUST00000033433.3 RNA binding motif protein, X-linked 2 (from RefSeq NM_173376.3) A2AF74 ENSMUST00000033433.1 ENSMUST00000033433.2 NM_173376 Q3TI42 Q8R0F5 RBMX2_MOUSE uc009tct.1 uc009tct.2 uc009tct.3 Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well- formed active site but still cannot catalyze the branching reaction and is composed of at least 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Component of the minor spliceosome, which splices U12-type introns (By similarity). Nucleus Belongs to the IST3 family. mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus spliceosomal complex U2 snRNP mRNA processing RNA splicing U2-type precatalytic spliceosome first spliceosomal transesterification activity uc009tct.1 uc009tct.2 uc009tct.3 
ENSMUST00000033442.14 Igsf1 ENSMUST00000033442.14 immunoglobulin superfamily, member 1, transcript variant 1 (from RefSeq NM_177591.4) ENSMUST00000033442.1 ENSMUST00000033442.10 ENSMUST00000033442.11 ENSMUST00000033442.12 ENSMUST00000033442.13 ENSMUST00000033442.2 ENSMUST00000033442.3 ENSMUST00000033442.4 ENSMUST00000033442.5 ENSMUST00000033442.6 ENSMUST00000033442.7 ENSMUST00000033442.8 ENSMUST00000033442.9 IGSF1_MOUSE Kiaa0364 NM_177591 Q6ZQD0 Q7TQ99 Q7TQA0 Q7TQA1 Q8BMN5 uc009tdh.1 uc009tdh.2 uc009tdh.3 uc009tdh.4 uc009tdh.5 Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B. Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription (By similarity). Interacts with INHA; the interaction is not confirmed by standard receptor binding assays (By similarity). Interacts with ACVR1B; the interaction appears to be ligand-dependent as it is diminished by inhibin B and activin A. Interacts with ACVR2A, ACVR2B, ACVRL1 and BMPR1B (By similarity). Interacts with HECTD1 (By similarity). [Isoform 1]: Membrane ; Multi-pass membrane protein [Isoform 2]: Membrane ; Multi-pass membrane protein [Isoform 3]: Membrane ; Multi-pass membrane protein [Isoform 4]: Secreted [Isoform 5]: Secreted Event=Alternative promoter usage, Alternative splicing; Named isoforms=5; Name=1; Synonyms=InhBP-L, long; IsoId=Q7TQA1-1; Sequence=Displayed; Name=2; IsoId=Q7TQA1-2; Sequence=VSP_031203; Name=3; Synonyms=InhBP-3; IsoId=Q7TQA1-3; Sequence=VSP_031201, VSP_031202; Name=4; Synonyms=InhBP-S, short; IsoId=Q7TQA1-4; Sequence=VSP_031199, VSP_031200; Name=5; Synonyms=InhBP-4, variant 4; IsoId=Q7TQA1-5; Sequence=VSP_031198; Expressed at embryonic day (E) 12.5 in embryo. Mice are viable and fertile and show no alterations in FSH synthesis or secretion or in ovarian and testicular function. According to PubMed:23143598 male mice show diminished pituitary and serum thyroid-stimulating hormone (TSH) concentrations, reduced pituitary thyrotropin-releasing hormone (TRH) receptor expression, decreased triiodothyronine concentrations and increased body mass. [Isoform 1]: Produced by alternative promoter usage. [Isoform 2]: Produced by alternative splicing of isoform 1. [Isoform 3]: Produced by alternative splicing of isoform 1. [Isoform 4]: Produced by alternative splicing of isoform 1. [Isoform 5]: Produced by alternative promoter usage. It is uncertain whether Met-1 or Met-2 is the initiator. Sequence=BAC97936.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; extracellular region regulation of transcription, DNA-templated coreceptor activity membrane integral component of membrane negative regulation of activin receptor signaling pathway inhibin binding activin receptor antagonist activity uc009tdh.1 uc009tdh.2 uc009tdh.3 uc009tdh.4 uc009tdh.5 
ENSMUST00000033444.11 Stk26 ENSMUST00000033444.11 serine/threonine kinase 26, transcript variant 1 (from RefSeq NM_133729.3) ENSMUST00000033444.1 ENSMUST00000033444.10 ENSMUST00000033444.2 ENSMUST00000033444.3 ENSMUST00000033444.4 ENSMUST00000033444.5 ENSMUST00000033444.6 ENSMUST00000033444.7 ENSMUST00000033444.8 ENSMUST00000033444.9 Mst4 NM_133729 Q99JT2 STK26_MOUSE Stk26 uc009tdr.1 uc009tdr.2 uc009tdr.3 uc009tdr.4 Serine/threonine-protein kinase that acts as a mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage (By similarity). Homodimer. Interacts with PDCD10. Interacts with GOLGA2. Interacts with CTTNBP2NL. Interacts with RIPOR1 (via C-terminus); this interaction occurs in a PDCD10-dependent and Rho-independent manner. Interacts with PDCD10; this interaction is required for the association of STK26 with RIPOR1. Cytoplasm Golgi apparatus Note=Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Golgi membrane nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm Golgi apparatus Golgi-associated vesicle cytosol protein phosphorylation apoptotic process cellular response to starvation membrane kinase activity phosphorylation apical plasma membrane transferase activity signal transduction by protein phosphorylation microvillus assembly negative regulation of cell migration activation of protein kinase activity response to hydrogen peroxide identical protein binding protein homodimerization activity regulation of apoptotic process protein autophosphorylation metal ion binding perinuclear region of cytoplasm cell periphery regulation of hydrogen peroxide-induced cell death uc009tdr.1 uc009tdr.2 uc009tdr.3 uc009tdr.4 
ENSMUST00000033449.8 Magea14 ENSMUST00000033449.8 MAGE family member A14 (from RefSeq NM_028851.1) 1700080O16Rik ENSMUST00000033449.1 ENSMUST00000033449.2 ENSMUST00000033449.3 ENSMUST00000033449.4 ENSMUST00000033449.5 ENSMUST00000033449.6 ENSMUST00000033449.7 Magea14 NM_028851 Q9D9G4 Q9D9G4_MOUSE uc012hha.1 uc012hha.2 molecular_function cellular_component biological_process uc012hha.1 uc012hha.2 
ENSMUST00000033450.3 Gpc4 ENSMUST00000033450.3 glypican 4 (from RefSeq NM_008150.2) ENSMUST00000033450.1 ENSMUST00000033450.2 GPC4_MOUSE NM_008150 P51655 Q923C8 uc012hhb.1 uc012hhb.2 uc012hhb.3 Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system. Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. [Secreted glypican-4]: Secreted, extracellular space Highly expressed in developing brain and kidney. Knockout mice have short fore and hind paws, and display a significant decrease in the length of the snout. Belongs to the glypican family. extracellular region extracellular space Golgi lumen plasma membrane external side of plasma membrane regulation of signal transduction cell surface membrane cell migration anchored component of membrane synapse anchored component of plasma membrane glutamatergic synapse anchored component of presynaptic membrane synaptic membrane adhesion regulation of protein localization to membrane regulation of presynapse assembly uc012hhb.1 uc012hhb.2 uc012hhb.3 
ENSMUST00000033458.3 3830403N18Rik ENSMUST00000033458.3 RIKEN cDNA 3830403N18 gene (from RefSeq NM_027510.2) 3830403N18Rik ENSMUST00000033458.1 ENSMUST00000033458.2 NM_027510 Q9D6C3 Q9D6C3_MOUSE uc009tfy.1 uc009tfy.2 uc009tfy.3 Belongs to the XLR/SYCP3 family. synaptonemal complex hematopoietic progenitor cell differentiation molecular_function spermatogenesis spermatid development meiotic cell cycle uc009tfy.1 uc009tfy.2 uc009tfy.3 
ENSMUST00000033463.10 Slc9a9 ENSMUST00000033463.10 solute carrier family 9 (sodium/hydrogen exchanger), member 9 (from RefSeq NM_177909.5) ENSMUST00000033463.1 ENSMUST00000033463.2 ENSMUST00000033463.3 ENSMUST00000033463.4 ENSMUST00000033463.5 ENSMUST00000033463.6 ENSMUST00000033463.7 ENSMUST00000033463.8 ENSMUST00000033463.9 NM_177909 Nhe9 Q3U0X0 Q8BZ00 SL9A9_MOUSE uc009ray.1 uc009ray.2 uc009ray.3 uc009ray.4 Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (PubMed:17005858). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters (PubMed:29362376, PubMed:24065030). Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain (By similarity). Regulates synaptic transmission by regulating the luminal pH of axonal endosomes (PubMed:29362376). Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages (PubMed:35716776). Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH (PubMed:17005858). Reaction=H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out); Xref=Rhea:RHEA:29419, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101; Evidence=; Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out); Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103; Evidence=; Homodimer; phosphatidylinositol-4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) could be involved in the dimer stabilization (By similarity). Interacts (via the C-terminus) with RACK1 (By similarity). Interacts with CHP1 (By similarity). Late endosome membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein Note=Localized to the plasma membrane in inner ear hair cell bundle (PubMed:17005858). Interacts with CHP1 (By similarity). Expressed in the brain (PubMed:24065030). Highly expressed in immune cells, specifically macrophages (PubMed:35716776). Expression is relatively low during development and begins to increase only postnatally, peaking at around postnatal day 50 and declining thereafter. Down-regulated upon bacterial infection in macrophages. Deficient mice do not show obvious changes in gross hippocampal morphology or impairments in locomotion, anxiety, smell, or pain sensitivity, however they display autism-like traits, such as reduced ultrasonic vocalization (number of calls and duration), decreased preference for social novelty, and display an increased time self-grooming (PubMed:26755066). Nervous system-specific conditional knockout mice show abnormal social and olfactive behavior, abnormal CNS synaptic transmission, impaired synaptic vesicle exocytosis, impaired presynaptic calcium entry, and decreased synaptic vesicle pH (PubMed:29362376). Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. endosome plasma membrane ion transport cation transport sodium ion transport regulation of pH antiporter activity solute:proton antiporter activity sodium:proton antiporter activity potassium:proton antiporter activity membrane integral component of membrane late endosome membrane regulation of intracellular pH recycling endosome transmembrane transport potassium ion transmembrane transport anion transmembrane transport sodium ion import across plasma membrane hydrogen ion transmembrane transport uc009ray.1 uc009ray.2 uc009ray.3 uc009ray.4 
ENSMUST00000033464.4 Brs3 ENSMUST00000033464.4 bombesin-like receptor 3 (from RefSeq NM_009766.3) BRS3_MOUSE ENSMUST00000033464.1 ENSMUST00000033464.2 ENSMUST00000033464.3 NM_009766 O54798 O88790 Q544G9 uc009tgu.1 uc009tgu.2 Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Interacts with C6orf89. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity bombesin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane bombesin receptor signaling pathway neuron projection neuronal cell body uc009tgu.1 uc009tgu.2 
ENSMUST00000033465.10 Vgll1 ENSMUST00000033465.10 vestigial like family member 1, transcript variant 2 (from RefSeq NM_133251.2) A2AFJ9 ENSMUST00000033465.1 ENSMUST00000033465.2 ENSMUST00000033465.3 ENSMUST00000033465.4 ENSMUST00000033465.5 ENSMUST00000033465.6 ENSMUST00000033465.7 ENSMUST00000033465.8 ENSMUST00000033465.9 NM_133251 Q99NC0 VGLL1_MOUSE uc009tgz.1 uc009tgz.2 uc009tgz.3 May act as a specific coactivator for the mammalian TEFs. Interacts with TEFs. Q99NC0; Q62296-1: Tead4; NbExp=4; IntAct=EBI-15985690, EBI-15985676; Nucleus Belongs to the vestigial family. protein binding nucleus regulation of transcription, DNA-templated protein C-terminus binding uc009tgz.1 uc009tgz.2 uc009tgz.3 
ENSMUST00000033466.2 Cd40lg ENSMUST00000033466.2 CD40 ligand (from RefSeq NM_011616.3) Cd40lg ENSMUST00000033466.1 NM_011616 Q0VEI3 Q0VEI3_MOUSE Tnlg8b uc009thb.1 uc009thb.2 Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. [CD40 ligand, soluble form]: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling. Homotrimer. Cell surface Belongs to the tumor necrosis factor family. cytokine activity tumor necrosis factor receptor binding CD40 receptor binding extracellular space inflammatory response immune response activation of JUN kinase activity cell surface membrane integral component of membrane platelet activation positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-4 production B cell proliferation positive regulation of T cell proliferation negative regulation of apoptotic process positive regulation of NF-kappaB transcription factor activity positive regulation of endothelial cell apoptotic process uc009thb.1 uc009thb.2 
ENSMUST00000033468.11 Arhgef6 ENSMUST00000033468.11 Rac/Cdc42 guanine nucleotide exchange factor 6, transcript variant 1 (from RefSeq NM_152801.3) ARHG6_MOUSE ENSMUST00000033468.1 ENSMUST00000033468.10 ENSMUST00000033468.2 ENSMUST00000033468.3 ENSMUST00000033468.4 ENSMUST00000033468.5 ENSMUST00000033468.6 ENSMUST00000033468.7 ENSMUST00000033468.8 ENSMUST00000033468.9 NM_152801 Q8C9V4 Q8K4I3 uc009thd.1 uc009thd.2 uc009thd.3 Acts as a RAC1 guanine nucleotide exchange factor (GEF). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Interacts with BIN2. Identified in a complex with BIN2 and GIT2 (By similarity). Interacts with PARVB. Q8K4I3; Q9HBI1: PARVB; Xeno; NbExp=3; IntAct=EBI-6272809, EBI-1047679; Cell projection, lamellipodium Detected in adult heart, spleen, lung, skeletal muscle, kidney and testis. Detected throughout embryogenesis. guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding cell-cell junction lamellipodium lamellipodium assembly regulation of Rho protein signal transduction intracellular signal transduction cell projection uc009thd.1 uc009thd.2 uc009thd.3 
ENSMUST00000033473.12 Fgf13 ENSMUST00000033473.12 fibroblast growth factor 13, transcript variant 1 (from RefSeq NM_010200.3) B1AU21 ENSMUST00000033473.1 ENSMUST00000033473.10 ENSMUST00000033473.11 ENSMUST00000033473.2 ENSMUST00000033473.3 ENSMUST00000033473.4 ENSMUST00000033473.5 ENSMUST00000033473.6 ENSMUST00000033473.7 ENSMUST00000033473.8 ENSMUST00000033473.9 FGF13_MOUSE Fgf13 Fhf2 NM_010200 O35338 P70377 Q3UR31 Q8VCY9 Q9JLA5 uc009tht.1 uc009tht.2 uc009tht.3 uc009tht.4 uc009tht.5 Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (PubMed:22726441). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (PubMed:22726441). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (PubMed:22726441). Regulates voltage-gated sodium channel transport and function (PubMed:21817159). May also play a role in MAPK signaling (PubMed:11378392, PubMed:12244047). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (PubMed:30679375). [Isoform 1]: Seems not to be involved in neuroblast polarization and migration but regulates axon branching. Interacts with SCN8A; regulates SCN8A activity (By similarity). Interacts with SCN1A; may regulate SCN1A activity (By similarity). Interacts with SCN5A; the interaction is direct and may regulate SNC5A density at membranes and function (PubMed:21817159). May also interact with SCN2A and SCN11A (By similarity). Interacts with MAPK8IP2; may regulate the MAPK8IP2 scaffolding activity (PubMed:11378392). Cell projection, filopodium Cell projection, growth cone Cell projection, dendrite Cell membrane, sarcolemma Cytoplasm Note=Not secreted. Localizes to the lateral membrane and intercalated disks of myocytes. [Isoform 1]: Nucleus [Isoform 2]: Cytoplasm Nucleus [Isoform 3]: Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=FGF13A, mFHF-2(1S) , FGF13-S; IsoId=P70377-1; Sequence=Displayed; Name=2; Synonyms=FGF13B, mFHF-2(1U) , FGF13-U; IsoId=P70377-2; Sequence=VSP_044131; Name=3; Synonyms=FGF13-VY, mFHF-2(1Y+1V) ; IsoId=P70377-3; Sequence=VSP_044130; Detected in brain, eye and heart. In brain, the different isoforms display different patterns of expression. Expressed in brain and heart (at protein level). Isoform 3 is highly expressed in cardiac myocytes while isoform 1 is the most abundant in brain. Expressed in the subplate of the embryonic cortex and the axonal tracts in the intermediate zone, and in axonal tracts of projection neurons, specifically in the corticothalamic tract and the corpus callosum (at protein level). Isoform 2 is transiently expressed in the neocortex and hippocampus from 17 dpc to P7 (at protein level). In embryonic brain, present in all divisions of the central and peripheral nervous system and it is at least 5 times more abundant than other FHFs. Detected in the subplate, ganglionic eminences, and proliferative zones of the cortical wall at 14 dpc. Detected in the cortical plate of the cerebral cortex, hippocampus, and striatum from 17 dpc to P14. Expression is markedly reduced in adult brain where it is most abundant in hippocampus. Also detected in developing kidney. Expressed in developing chandelier neurons. May be phosphorylated. Conditional knockout mice lacking fgf13 in the cerebral cortex or mice lacking fgf13 in most tissues display similar phenotypes of impaired spatial acquisition and memory. The cued memory and the capacity of novel object recognition are altered. They also display anxiety-related and reduced depression-like behaviors. This is associated with a disorganization of cortical structure and neural circuits. The laminar formation of the neocortex is delayed and the hippocampal development is also affected. Belongs to the heparin-binding growth factors family. MAPK cascade neuron migration extracellular region nucleus cytoplasm cytosol microtubule plasma membrane sodium ion transport negative regulation of microtubule depolymerization nervous system development learning memory microtubule binding growth factor activity intercalated disc lateral plasma membrane sodium channel regulator activity hippocampus development cerebral cortex cell migration filopodium protein kinase activator activity axon dendrite growth cone activation of protein kinase activity cell projection neuron projection ion channel binding establishment of neuroblast polarity microtubule polymerization beta-tubulin binding negative regulation of collateral sprouting protein localization to plasma membrane regulation of cardiac muscle cell action potential involved in regulation of contraction response to odorant apoptotic process cell proliferation uc009tht.1 uc009tht.2 uc009tht.3 uc009tht.4 uc009tht.5 
ENSMUST00000033477.5 F9 ENSMUST00000033477.5 coagulation factor IX, transcript variant 1 (from RefSeq NM_007979.2) Cf9 ENSMUST00000033477.1 ENSMUST00000033477.2 ENSMUST00000033477.3 ENSMUST00000033477.4 FA9_MOUSE NM_007979 P16294 Q3UES1 uc009thw.1 uc009thw.2 uc009thw.3 uc009thw.4 This gene encodes a vitamin K-dependent serine protease that plays a critical role in the intrinsic pathway of blood coagulation. The encoded protein is an inactive zymogen that is activated by coagulation factor XIa to generate factor IXa, a heterodimer containing heavy and light chains. In association with factor VIII, membrane phospholipids and calcium ions, factor IXa cleaves the inactive zymogen factor X to generate active factor Xa. Genetic deletion of this gene in mice results in a severe bleeding phenotype. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Reaction=Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.; EC=3.4.21.22; Evidence=; Heterodimer of a light chain and a heavy chain; disulfide- linked. Interacts with SERPINC1. Secreted Detected in liver. Calcium binds to the gamma-carboxyglutamic acid (Gla) residues in the Gla domain. Calcium can also bind, with stronger affinity, to another site beyond the Gla domain. Under physiological ion concentrations, Ca(2+) is displaced by Mg(2+) from some of the gammaglutamate residues in the N-terminal Gla domain. This leads to a subtle conformation change that may affect the interaction with its binding protein. Activated by factor XIa, which excises the activation peptide. The propeptide can also be removed by snake venom protease. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Predominantly O-glucosylated at Ser-99 by POGLUT1 in vitro. Belongs to the peptidase S1 family. endopeptidase activity serine-type endopeptidase activity calcium ion binding extracellular region extracellular space proteolysis blood coagulation hemostasis peptidase activity serine-type peptidase activity hydrolase activity zymogen activation metal ion binding uc009thw.1 uc009thw.2 uc009thw.3 uc009thw.4 
ENSMUST00000033480.13 Atp11c ENSMUST00000033480.13 ATPase, class VI, type 11C, transcript variant 3 (from RefSeq NM_001359002.1) Atp11c E9QKK8 E9QKK8_MOUSE ENSMUST00000033480.1 ENSMUST00000033480.10 ENSMUST00000033480.11 ENSMUST00000033480.12 ENSMUST00000033480.2 ENSMUST00000033480.3 ENSMUST00000033480.4 ENSMUST00000033480.5 ENSMUST00000033480.6 ENSMUST00000033480.7 ENSMUST00000033480.8 ENSMUST00000033480.9 NM_001359002 uc009tib.1 uc009tib.2 uc009tib.3 Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Membrane ulti-pass membrane protein Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. nucleotide binding magnesium ion binding ATP binding phospholipid transport membrane integral component of membrane phospholipid translocation uc009tib.1 uc009tib.2 uc009tib.3 
ENSMUST00000033483.5 Ccdc22 ENSMUST00000033483.5 coiled-coil domain containing 22 (from RefSeq NM_138603.3) B1AVA1 CCD22_MOUSE DXImx40e ENSMUST00000033483.1 ENSMUST00000033483.2 ENSMUST00000033483.3 ENSMUST00000033483.4 NM_138603 Q8BYH4 Q9JIG7 uc009sln.1 uc009sln.2 uc009sln.3 Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Interacts with CPNE1 and CPNE4 (PubMed:12522145). Interacts with COMMD1, COMMD2 COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10. Interacts with CUL1, CUL2, CUL3, SKP1, BTRC. Interacts with CCDC93; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22 and CCDC93; in the complex interacts directly with CCDC93. Interacts with VPS35L; associates with the retriever complex. Interacts with SNX17 and SNX31 (By similarity). Endosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Belongs to the CCDC22 family. molecular_function protein binding cellular_component endosome cellular copper ion homeostasis Golgi to plasma membrane transport cytoplasmic sequestering of NF-kappaB biological_process protein transport endocytic recycling cholesterol homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling regulation of plasma lipoprotein particle levels cullin family protein binding retrograde transport, endosome to plasma membrane positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc009sln.1 uc009sln.2 uc009sln.3 
ENSMUST00000033486.6 Plp2 ENSMUST00000033486.6 proteolipid protein 2 (from RefSeq NM_019755.5) ENSMUST00000033486.1 ENSMUST00000033486.2 ENSMUST00000033486.3 ENSMUST00000033486.4 ENSMUST00000033486.5 NM_019755 PLP2_MOUSE Q3U4I3 Q9R1Q7 uc009slx.1 uc009slx.2 uc009slx.3 May play a role in cell differentiation in the intestinal epithelium. Membrane ; Multi-pass membrane protein plasma membrane membrane integral component of membrane chemokine binding uc009slx.1 uc009slx.2 uc009slx.3 
ENSMUST00000033489.8 Praf2 ENSMUST00000033489.8 PRA1 domain family 2 (from RefSeq NM_138602.4) DXImx39e ENSMUST00000033489.1 ENSMUST00000033489.2 ENSMUST00000033489.3 ENSMUST00000033489.4 ENSMUST00000033489.5 ENSMUST00000033489.6 ENSMUST00000033489.7 NM_138602 PRAF2_MOUSE Q9JIG8 uc009sme.1 uc009sme.2 uc009sme.3 May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (By similarity). Interacts with CCR5 and GDE1. Endosome membrane ; Multi-pass membrane protein Belongs to the PRA1 family. molecular_function cellular_component endosome biological_process endosome membrane protein transport membrane integral component of membrane uc009sme.1 uc009sme.2 uc009sme.3 
ENSMUST00000033490.13 Ccdc120 ENSMUST00000033490.13 coiled-coil domain containing 120 (from RefSeq NM_207202.2) A2AEV7 A2AEV8 CC120_MOUSE Ccdc120 ENSMUST00000033490.1 ENSMUST00000033490.10 ENSMUST00000033490.11 ENSMUST00000033490.12 ENSMUST00000033490.2 ENSMUST00000033490.3 ENSMUST00000033490.4 ENSMUST00000033490.5 ENSMUST00000033490.6 ENSMUST00000033490.7 ENSMUST00000033490.8 ENSMUST00000033490.9 NM_207202 uc009smf.1 uc009smf.2 uc009smf.3 Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth (By similarity). Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth (By similarity). Interacts with NIN and CEP170; leading to recruit them to centrosomes (By similarity). Interacts with CYTH2; this interaction is direct and stabilizes CCDC120, possibly by preventing ubiquitination (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm Cell projection, neuron projection Cell projection, growth cone Endosome Note=Localizes to the subdistal appendages of mother centrioles and proximal ends of both centrioles in interphase cells (By similarity). Recruited to subdistal appendages by ODF2 (By similarity). In differentiating neuroblastoma cells, colocalizes with CYTH2 in both neurite shaft and growth cone areas (By similarity). Partially colocalizes with endosomes along neurites in differentiating neuroblastoma cells (By similarity). Ubiquitinated; interaction with CYTH2 may prevent ubiquitination. molecular_function cytoplasm endosome centriole cytoskeleton multicellular organism development protein localization growth cone microtubule anchoring at centrosome cell projection uc009smf.1 uc009smf.2 uc009smf.3 
ENSMUST00000033494.16 Otud5 ENSMUST00000033494.16 OTU domain containing 5, transcript variant 2 (from RefSeq NM_138604.4) DXImx46e ENSMUST00000033494.1 ENSMUST00000033494.10 ENSMUST00000033494.11 ENSMUST00000033494.12 ENSMUST00000033494.13 ENSMUST00000033494.14 ENSMUST00000033494.15 ENSMUST00000033494.2 ENSMUST00000033494.3 ENSMUST00000033494.4 ENSMUST00000033494.5 ENSMUST00000033494.6 ENSMUST00000033494.7 ENSMUST00000033494.8 ENSMUST00000033494.9 NM_138604 OTUD5_MOUSE Otud5 Q3U2S4 Q3UE33 Q91YL5 Q9CV50 Q9JIG6 Sfc7 uc009smu.1 uc009smu.2 uc009smu.3 Deubiquitinating enzyme that functions as a negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1. Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Inhibited by N-ethyl-maleimide (NEM). Interacts with TRAF3. Q3U2S4-1; Q80TP3: Ubr5; NbExp=2; IntAct=EBI-16131219, EBI-2553642; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U2S4-1; Sequence=Displayed; Name=2; IsoId=Q3U2S4-2; Sequence=VSP_023196; Phosphorylation at Ser-177 is required for deubiquitinating activity. Phosphorylation at Ser-323, Ser-332 and Ser-503 by MTOR promotes its activity. Mutant mice die at the embryo stage. Belongs to the peptidase C85 family. thiol-dependent ubiquitin-specific protease activity protein binding cellular_component proteolysis peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity regulation of protein stability response to lipopolysaccharide thiol-dependent ubiquitinyl hydrolase activity proteasome-mediated ubiquitin-dependent protein catabolic process CD8-positive, alpha-beta T cell differentiation Lys63-specific deubiquitinase activity protein K63-linked deubiquitination protein K48-linked deubiquitination T-helper 17 cell lineage commitment interleukin-9 secretion interleukin-21 secretion ubiquitinyl hydrolase activity negative regulation of interleukin-17 secretion Lys48-specific deubiquitinase activity regulation of T-helper 17 type immune response uc009smu.1 uc009smu.2 uc009smu.3 
ENSMUST00000033495.16 Pim2 ENSMUST00000033495.16 proviral integration site 2 (from RefSeq NM_138606.2) A2AER1 ENSMUST00000033495.1 ENSMUST00000033495.10 ENSMUST00000033495.11 ENSMUST00000033495.12 ENSMUST00000033495.13 ENSMUST00000033495.14 ENSMUST00000033495.15 ENSMUST00000033495.2 ENSMUST00000033495.3 ENSMUST00000033495.4 ENSMUST00000033495.5 ENSMUST00000033495.6 ENSMUST00000033495.7 ENSMUST00000033495.8 ENSMUST00000033495.9 NM_138606 PIM2_MOUSE Pim-2 Q62070 Q62071 Q62072 Q8R2P0 uc009smz.1 uc009smz.2 uc009smz.3 uc009smz.4 uc009smz.5 Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro- apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl- X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts with MYC. Event=Alternative initiation; Named isoforms=3; Name=1; IsoId=Q62070-1; Sequence=Displayed; Name=2; IsoId=Q62070-2; Sequence=VSP_018854, VSP_018855; Name=3; IsoId=Q62070-3; Sequence=VSP_018856; Widely expressed, with highest expression in spleen, thymus and brain. Expressed in epiphyseal chondrocytes. Induced by a wide range of growth factors and mitogens; IL2, IL3, IL4, IL7,IL9 and by interferon-gamma (IFNG). Autophosphorylated. Mice are viable and fertile. Deficient mice shown reduced T-cell activation and expansion in the presence of the serine/threonine protein kinase mTOR inhibitor rapamycin. Triple knockout mice PIM1/PIM2/PIM3 shown a profound reduction in body size at birth and throughout postnatal life due to a reduction in the number of cells rather than cell size. [Isoform 1]: Initiates from CTG codon. [Isoform 2]: Initiates from CTG codon. [Isoform 3]: Mutagen in position: 61:K->A (loss of kinase activity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. G1/S transition of mitotic cell cycle nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm protein phosphorylation apoptotic process cell cycle regulation of mitotic cell cycle negative regulation of cell proliferation apoptotic mitochondrial changes response to virus positive regulation of autophagy positive regulation of macroautophagy kinase activity phosphorylation transferase activity negative regulation of protein binding negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription, DNA-templated protein autophosphorylation protein stabilization uc009smz.1 uc009smz.2 uc009smz.3 uc009smz.4 uc009smz.5 
ENSMUST00000033497.9 Pqbp1 ENSMUST00000033497.9 polyglutamine binding protein 1, transcript variant 4 (from RefSeq NM_001426251.1) ENSMUST00000033497.1 ENSMUST00000033497.2 ENSMUST00000033497.3 ENSMUST00000033497.4 ENSMUST00000033497.5 ENSMUST00000033497.6 ENSMUST00000033497.7 ENSMUST00000033497.8 NM_001426251 Npw38 PQBP1_MOUSE Q80WW2 Q91VJ5 Q9ER43 Q9QYY2 uc009snd.1 uc009snd.2 uc009snd.3 uc009snd.4 Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (By similarity). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner (By similarity). Can activate transcription directly or via association with the transcription machinery (By similarity). May be involved in ATXN1 mutant-induced cell death (By similarity). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (By similarity). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (By similarity). Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse- transcribed DNA in the cytosol (By similarity). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (By similarity). Interacts with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. Interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. Forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. Interacts (via C-terminus) with TXNL4A and CD2BP2. Interacts (via WW domain) with ATN1 and SF3B1, and may interact with additional splice factors. Interacts (via WW domain) with WBP11; Leading to reduce interaction between PQBP1 and TXNL4A. Interacts with CAPRIN1. Interacts with DDX1. Interacts with SFPQ. Interacts with KHSRP. Nucleus Nucleus speckle Cytoplasmic granule Note=Colocalizes with SRSF2 in nuclear speckles (PubMed:23512658). Colocalized with POU3F2. Colocalized with ATXN1 in nuclear inclusion bodies. Localizes to cytoplasmic stress granules (By similarity). Detected in brain cortex and hippocampus neurons (at protein level). Expressed in brain with high level in cerebellar cortex, hippocampus and olfactory bulb. The WW domain may play a role as a transcriptional activator directly or via association with the transcription machinery. The WW domain mediates interaction with WBP11, ATN1, SF3B1 and the C-terminal domain of the RNA polymerase II large subunit. Except for the WW domain, the protein is intrinsically disordered. alternative mRNA splicing, via spliceosome activation of innate immune response positive regulation of defense response to virus by host immune system process double-stranded DNA binding nucleus cytoplasm centrosome cytosol cilium mRNA processing protein C-terminus binding RNA splicing cytoplasmic stress granule nuclear speck neuron projection development positive regulation of type I interferon production ribonucleoprotein complex binding regulation of RNA splicing innate immune response regulation of dendrite morphogenesis defense response to virus cellular response to exogenous dsRNA neuronal ribonucleoprotein granule ciliary base positive regulation of non-motile cilium assembly uc009snd.1 uc009snd.2 uc009snd.3 uc009snd.4 
ENSMUST00000033498.11 Timm17b ENSMUST00000033498.11 translocase of inner mitochondrial membrane 17b, transcript variant 3 (from RefSeq NR_132589.1) ENSMUST00000033498.1 ENSMUST00000033498.10 ENSMUST00000033498.2 ENSMUST00000033498.3 ENSMUST00000033498.4 ENSMUST00000033498.5 ENSMUST00000033498.6 ENSMUST00000033498.7 ENSMUST00000033498.8 ENSMUST00000033498.9 NR_132589 Q9Z0V7 TI17B_MOUSE Tim17b uc009sne.1 uc009sne.2 uc009sne.3 uc009sne.4 uc009sne.5 Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex. The complex also interacts with DNAJC15 (By similarity). Mitochondrion inner membrane; Multi-pass membrane protein. Belongs to the Tim17/Tim22/Tim23 family. mitochondrion mitochondrial inner membrane mitochondrial inner membrane presequence translocase complex intracellular protein transport protein transport P-P-bond-hydrolysis-driven protein transmembrane transporter activity membrane integral component of membrane protein import into mitochondrial matrix integral component of mitochondrial inner membrane protein transmembrane transporter activity uc009sne.1 uc009sne.2 uc009sne.3 uc009sne.4 uc009sne.5 
ENSMUST00000033500.5 Eras ENSMUST00000033500.5 ES cell-expressed Ras (from RefSeq NM_181548.2) ENSMUST00000033500.1 ENSMUST00000033500.2 ENSMUST00000033500.3 ENSMUST00000033500.4 NM_181548 Q7TN89 RASE_MOUSE uc009sng.1 uc009sng.2 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide- exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Interacts with PIK3CD. Cell membrane ; Lipid-anchor ; Cytoplasmic side Expressed in several undifferentiated mouse embryonic stem cell lines. Belongs to the small GTPase superfamily. Ras family. nucleotide binding GTPase activity GTP binding plasma membrane signal transduction Ras protein signal transduction membrane GDP binding uc009sng.1 uc009sng.2 
ENSMUST00000033502.14 Gata1 ENSMUST00000033502.14 GATA binding protein 1, transcript variant 3 (from RefSeq NM_008089.3) ENSMUST00000033502.1 ENSMUST00000033502.10 ENSMUST00000033502.11 ENSMUST00000033502.12 ENSMUST00000033502.13 ENSMUST00000033502.2 ENSMUST00000033502.3 ENSMUST00000033502.4 ENSMUST00000033502.5 ENSMUST00000033502.6 ENSMUST00000033502.7 ENSMUST00000033502.8 ENSMUST00000033502.9 GATA1_MOUSE Gf-1 NM_008089 P17679 Q3UIH9 Q7TMX8 uc009snl.1 uc009snl.2 uc009snl.3 Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (By similarity). May form homodimers or heterodimers with other isoforms. Interacts (via the N-terminal zinc finger) with ZFPM1 (By similarity). Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner. Interacts with LMCD1. Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo. Interacts with BRD3. Interacts with MED1, CCAR1 and CALCOCO1. Interacts with EP300 (By similarity). Interacts with CEBPE (By similarity). P17679; P25801: Lmo2; NbExp=5; IntAct=EBI-3903251, EBI-3903256; P17679; P13405: Rb1; NbExp=3; IntAct=EBI-3903251, EBI-971782; P17679; P22091: Tal1; NbExp=2; IntAct=EBI-3903251, EBI-8006437; P17679; O35615: Zfpm1; NbExp=7; IntAct=EBI-3903251, EBI-4394596; P17679; Q9VPQ6: ush; Xeno; NbExp=2; IntAct=EBI-3903251, EBI-110692; Nucleus Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=P17679-1; Sequence=Displayed; Name=2; Synonyms=GATA-1s; IsoId=P17679-2; Sequence=VSP_041452; Erythrocytes. Expressed (at protein level) in liver. Detected at 11.5-day fetal livers (at protein level). Isoform 2 detected earlier at 8.5-day embryo. The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding. Highly phosphorylated on serine residues. Phosphorylation on Ser- 310 is enhanced on erythroid differentiation. Phosphorylation on Ser- 142 promotes sumoylation on Lys-137 (By similarity). Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation with SUMO1 has no effect on transcriptional activity. Acetylated on Lys-233, Lys-245 Lys-246 by EP300 (By similarity). Acetylated on Lys-246, Lys-252 and Lys-312 by CREBBP in vitro. Acetylation does not affect DNA-binding in vitro but is essential to induce erythroid differentiation and for binding chromatin in vivo. [Isoform 2]: Produced by alternative initiation at Met- 84 of isoform 1. Less effective than isoform 1 in its ability to transactivate target genes. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development p53 binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cell-cell signaling zinc ion binding negative regulation of cell proliferation DNA binding, bending male gonad development regulation of glycoprotein biosynthetic process regulation of definitive erythrocyte differentiation regulation of primitive erythrocyte differentiation transcriptional repressor complex myeloid cell differentiation erythrocyte differentiation megakaryocyte differentiation platelet formation basophil differentiation eosinophil differentiation negative regulation of bone mineralization chromatin DNA binding protein-DNA complex positive regulation of osteoblast proliferation embryonic hemopoiesis eosinophil fate commitment negative regulation of apoptotic process sequence-specific DNA binding positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding cell development erythrocyte development homeostasis of number of cells within a tissue positive regulation of peptidyl-tyrosine phosphorylation platelet aggregation C2H2 zinc finger domain binding transcriptional activation by promoter-enhancer looping dendritic cell differentiation cellular response to thyroid hormone stimulus negative regulation of transcription regulatory region DNA binding negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc009snl.1 uc009snl.2 uc009snl.3 
ENSMUST00000033503.3 Glod5 ENSMUST00000033503.3 glyoxalase domain containing 5 (from RefSeq NM_027227.2) ENSMUST00000033503.1 ENSMUST00000033503.2 GLOD5_MOUSE NM_027227 Q9D8I3 uc009snn.1 uc009snn.2 uc009snn.3 Belongs to the glyoxalase I family. molecular_function cellular_component biological_process uc009snn.1 uc009snn.2 uc009snn.3 
ENSMUST00000033505.7 Was ENSMUST00000033505.7 Wiskott-Aldrich syndrome (from RefSeq NM_009515.2) ENSMUST00000033505.1 ENSMUST00000033505.2 ENSMUST00000033505.3 ENSMUST00000033505.4 ENSMUST00000033505.5 ENSMUST00000033505.6 NM_009515 Q53WY0 Q53WY0_MOUSE Was uc009sns.1 uc009sns.2 uc009sns.3 uc009sns.4 Cytoplasm, cytoskeleton Nucleus regulation of T cell antigen processing and presentation actin binding nucleus cytosol actin filament immune response actin filament organization regulation of actin polymerization or depolymerization regulation of lamellipodium assembly SH3 domain binding protein kinase binding actin filament polymerization small GTPase binding Cdc42 protein signal transduction site of double-strand break identical protein binding phospholipase binding positive regulation of transcription from RNA polymerase II promoter Rac GTPase binding regulation of stress fiber assembly negative regulation of stress fiber assembly positive regulation of double-strand break repair via homologous recombination negative regulation of cell motility positive regulation of Arp2/3 complex-mediated actin nucleation uc009sns.1 uc009sns.2 uc009sns.3 uc009sns.4 
ENSMUST00000033506.13 Wdr13 ENSMUST00000033506.13 WD repeat domain 13, transcript variant 1 (from RefSeq NM_026137.5) ENSMUST00000033506.1 ENSMUST00000033506.10 ENSMUST00000033506.11 ENSMUST00000033506.12 ENSMUST00000033506.2 ENSMUST00000033506.3 ENSMUST00000033506.4 ENSMUST00000033506.5 ENSMUST00000033506.6 ENSMUST00000033506.7 ENSMUST00000033506.8 ENSMUST00000033506.9 NM_026137 Q91V09 WDR13_MOUSE uc009snv.1 uc009snv.2 uc009snv.3 uc009snv.4 Nucleus nucleus nucleoplasm microtubule organizing center plasma membrane negative regulation of type B pancreatic cell proliferation promoter-specific chromatin binding uc009snv.1 uc009snv.2 uc009snv.3 uc009snv.4 
ENSMUST00000033509.15 Ebp ENSMUST00000033509.15 EBP cholestenol delta-isomerase (from RefSeq NM_007898.3) EBP_MOUSE ENSMUST00000033509.1 ENSMUST00000033509.10 ENSMUST00000033509.11 ENSMUST00000033509.12 ENSMUST00000033509.13 ENSMUST00000033509.14 ENSMUST00000033509.2 ENSMUST00000033509.3 ENSMUST00000033509.4 ENSMUST00000033509.5 ENSMUST00000033509.6 ENSMUST00000033509.7 ENSMUST00000033509.8 ENSMUST00000033509.9 Ebp Msi NM_007898 P70245 Q9CSP4 uc009soi.1 uc009soi.2 uc009soi.3 This gene encodes a transmembrane protein that localizes to the endoplasmic reticulum. This protein catalyses the conversion of delta8 to delta7 sterols, an important step in sterol biosynthesis. Mutations in this gene are responsible for the mouse tattered mutant phenotype. Tattered males are embryonic lethal, while heterozygous females have developmental defects. Deficiency of the related gene in human causes X-linked dominant chondrodysplasia punctata. [provided by RefSeq, May 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. Reaction=lathosterol = 5alpha-cholest-8-en-3beta-ol; Xref=Rhea:RHEA:15281, ChEBI:CHEBI:16608, ChEBI:CHEBI:17168; EC=5.3.3.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15282; Evidence=; Reaction=zymosterol = 5alpha-cholesta-7,24-dien-3beta-ol; Xref=Rhea:RHEA:33999, ChEBI:CHEBI:16290, ChEBI:CHEBI:18252; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:34000; Evidence=; Steroid biosynthesis; cholesterol biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Nucleus envelope Cytoplasmic vesicle Note=During interphase, detected on the endoplasmic reticulum and the nuclear envelope. During mitosis, detected on cytoplasmic vesicles. Note=Defects in Ebp are a cause of 'Tattered' (Td) which is an X-linked, semidominant mouse mutation associated with prenatal male lethality. Heterozygous females are small and at 4 to 5 days of age develop patches of hyperkeratotic skin where no hair grows, resulting in a striping of the coat in adults. Craniofacial anomalies and twisted toes have also been observed in some affected females. Binds to the phenylalkylamine calcium-ion antagonist emopamil, an anti-ischemic drug. Belongs to the EBP family. C-8 sterol isomerase activity steroid delta-isomerase activity nucleus nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process steroid metabolic process cholesterol metabolic process membrane integral component of membrane sterol metabolic process sterol biosynthetic process isomerase activity hemopoiesis cytoplasmic vesicle intracellular membrane-bounded organelle cholestenol delta-isomerase activity uc009soi.1 uc009soi.2 uc009soi.3 
ENSMUST00000033513.10 Ftsj1 ENSMUST00000033513.10 FtsJ RNA 2'-O-methyltransferase 1, transcript variant 1 (from RefSeq NM_133991.3) A2ALH2 ENSMUST00000033513.1 ENSMUST00000033513.2 ENSMUST00000033513.3 ENSMUST00000033513.4 ENSMUST00000033513.5 ENSMUST00000033513.6 ENSMUST00000033513.7 ENSMUST00000033513.8 ENSMUST00000033513.9 Ftsj1 NM_133991 Q8CBC7 Q8JZY1 Q91XA6 TRM7_MOUSE uc009sop.1 uc009sop.2 Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:33771871). Requisite for faithful cytoplasmic translation (PubMed:33771871). Requires THADA for methylation of the cytidine at position 32 of the anticodon loop of substrate tRNAs (By similarity). Requires WDR6 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs (By similarity). Promotes translation efficiency of the UUU codon (PubMed:33771871). Plays a role in neurogenesis (PubMed:33771871, PubMed:36101392). Required for expression of genes involved in neurogenesis and mitochondrial translation and energy generation (PubMed:30557699, PubMed:33771871, PubMed:36101392). Requisite for RNA-mediated gene silencing (By similarity). May modify position 32 in tRNA(Arg(ACG)), tRNA(Gln(CUG)), tRNA(Leu(UAA)), tRNA(Leu(UAG)), tRNA(Leu(AAG)), tRNA(Leu(CAG)), tRNA(Phe(GAA)), tRNA(Trp(CCA)) and tRNA(Val(AAC)), and position 34 in tRNA(Phe(GAA)), tRNA(Leu(CAA)), tRNA(Leu(UAA)), tRNA(Sec(UCA)), and tRNA(Trp(CCA)) (PubMed:33771871). Reaction=cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42396, Rhea:RHEA- COMP:10246, Rhea:RHEA-COMP:10247, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74445, ChEBI:CHEBI:74495, ChEBI:CHEBI:82748; EC=2.1.1.205; Evidence=; Interacts with WDR6; the interaction is direct, and required for 2'-O-methylation of position 34 in substrate tRNAs. Cytoplasm Nucleus Note=Predominantly cytoplasmic. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CBC7-1; Sequence=Displayed; Name=2; IsoId=Q8CBC7-2; Sequence=VSP_061948; Name=3; IsoId=Q8CBC7-3; Sequence=VSP_061948, VSP_061949; Leads to a reduction in the level of tRNA(Phe(GAA)) in the brain, but not in the liver, kidney or testis (PubMed:33771871). The levels of tRNA(Leu(CAA)) and tRNA(Leu(UAA)) appear normal in the brain, liver, kidney and testis (PubMed:33771871). Impairs long-term potentiation and long-term depression in the hippocampus (PubMed:33771871, PubMed:36101392). Causes immature spine formation in hippocampal and cortical neurons, with an increase in thin dendritic spines and in the striatal neurons, with an increase in the immature filopodia-like spines (PubMed:33771871, PubMed:36101392). Decreases length and width of the postsynaptic density (PSD) of hippocampal and cortical neurons (PubMed:33771871). Leads to a reduction in the apical layer of the hippocampal CA1 area (PubMed:36101392). Slows spatial learning, impairs fear-conditioning and affects anxiety-like behaviors (PubMed:30557699, PubMed:33771871). Reduces blood sugar levels and platelet count, and decreases levels of alpha-amylase, cholesterol, triglycerides and creatinine (PubMed:30557699). Increases blood corticosterone levels (PubMed:30557699). Leads to a slight reduction in body size and weight (PubMed:30557699, PubMed:33771871). Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily. Sequence=AAH11144.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; RNA methylation tRNA nucleoside ribose methylation cytoplasmic translation cytoplasm tRNA processing methyltransferase activity tRNA methyltransferase activity tRNA (guanosine-2'-O-)-methyltransferase activity transferase activity tRNA methylation methylation tRNA (cytosine-2'-O-)-methyltransferase activity uc009sop.1 uc009sop.2 
ENSMUST00000033519.3 Dynlt3 ENSMUST00000033519.3 dynein light chain Tctex-type 3 (from RefSeq NM_025975.5) Dynlt3 ENSMUST00000033519.1 ENSMUST00000033519.2 NM_025975 Q542J7 Q542J7_MOUSE Tcte1l uc009spy.1 uc009spy.2 uc009spy.3 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis. Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton Nucleus Belongs to the dynein light chain Tctex-type family. kinetochore cytoplasm cytoplasmic dynein complex regulation of mitotic cell cycle identical protein binding positive regulation of mitotic cell cycle mitotic spindle astral microtubule uc009spy.1 uc009spy.2 uc009spy.3 
ENSMUST00000033522.15 Magea9 ENSMUST00000033522.15 MAGE family member A9 (from RefSeq NM_027512.2) 3830417A13Rik ENSMUST00000033522.1 ENSMUST00000033522.10 ENSMUST00000033522.11 ENSMUST00000033522.12 ENSMUST00000033522.13 ENSMUST00000033522.14 ENSMUST00000033522.2 ENSMUST00000033522.3 ENSMUST00000033522.4 ENSMUST00000033522.5 ENSMUST00000033522.6 ENSMUST00000033522.7 ENSMUST00000033522.8 ENSMUST00000033522.9 Magea9 NM_027512 Q8BQJ2 Q8BQJ2_MOUSE uc009tin.1 uc009tin.2 uc009tin.3 molecular_function cellular_component biological_process uc009tin.1 uc009tin.2 uc009tin.3 
ENSMUST00000033524.3 Ctag2 ENSMUST00000033524.3 cancer/testis antigen 2 (from RefSeq NM_027302.2) Ctag2 ENSMUST00000033524.1 ENSMUST00000033524.2 NM_027302 Q9D9S4 Q9D9S4_MOUSE uc009tiq.1 uc009tiq.2 uc009tiq.3 uc009tiq.4 Belongs to the CTAG/PCC1 family. EKC/KEOPS complex molecular_function positive regulation of transcription from RNA polymerase II promoter tRNA threonylcarbamoyladenosine metabolic process uc009tiq.1 uc009tiq.2 uc009tiq.3 uc009tiq.4 
ENSMUST00000033525.3 4930447F04Rik ENSMUST00000033525.3 4930447F04Rik (from geneSymbol) 4930447F04Rik A2AFR2 A2AFR2_MOUSE AK015402 ENSMUST00000033525.1 ENSMUST00000033525.2 uc292olc.1 uc292olc.2 molecular_function cellular_component biological_process uc292olc.1 uc292olc.2 
ENSMUST00000033532.7 Aff2 ENSMUST00000033532.7 AF4/FMR2 family, member 2 (from RefSeq NM_008032.4) AFF2_MOUSE Aff2 B1ATW0 ENSMUST00000033532.1 ENSMUST00000033532.2 ENSMUST00000033532.3 ENSMUST00000033532.4 ENSMUST00000033532.5 ENSMUST00000033532.6 Fmr2 NM_008032 O55112 Ox19 uc009tjb.1 uc009tjb.2 uc009tjb.3 RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. Nucleus speckle Note=When splicing or transcription are inhibited, accumulates in large, rounded speckles and in the nucleolus. Highly expressed in the hippocampus, the piriform cortex, Purkinje cells and the cingulate gyrus. Expressed before day 7 in the embryo and reached its highest levels at 10.5-11.5 days. In the embryo at day 11, expression is more specific in the roof of the hind brain and the lateral ventricle of the brain. Belongs to the AF4 family. G-quadruplex RNA binding RNA binding nucleus regulation of transcription, DNA-templated mRNA processing learning or memory RNA splicing regulation of gene expression negative regulation of gene expression nuclear speck nuclear speck organization regulation of RNA splicing double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription elongation factor complex ELL-EAF complex uc009tjb.1 uc009tjb.2 uc009tjb.3 
ENSMUST00000033537.3 4931400O07Rik ENSMUST00000033537.3 RIKEN cDNA 4931400O07 gene, transcript variant 1 (from RefSeq NR_164352.1) ENSMUST00000033537.1 ENSMUST00000033537.2 NR_164352 uc292okh.1 uc292okh.2 uc292okh.3 uc292okh.1 uc292okh.2 uc292okh.3 
ENSMUST00000033539.13 F8 ENSMUST00000033539.13 coagulation factor VIII, transcript variant 1 (from RefSeq NM_007977.2) A2AN88 Cf8 ENSMUST00000033539.1 ENSMUST00000033539.10 ENSMUST00000033539.11 ENSMUST00000033539.12 ENSMUST00000033539.2 ENSMUST00000033539.3 ENSMUST00000033539.4 ENSMUST00000033539.5 ENSMUST00000033539.6 ENSMUST00000033539.7 ENSMUST00000033539.8 ENSMUST00000033539.9 F8c FA8_MOUSE NM_007977 Q06194 uc009tpt.1 uc009tpt.2 uc009tpt.3 uc009tpt.4 uc009tpt.5 Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Interacts with vWF. vWF binding is essential for the stabilization of F8 in circulation (By similarity). Secreted, extracellular space. Found in most tissues. The binding of vWF and activation depend on the sulfation of Tyr- 1669. Proteolytically cleaved by cathepsin CTSG to produce a partially activated form. Belongs to the multicopper oxidase family. copper ion binding extracellular region extracellular space acute-phase response blood coagulation blood coagulation, intrinsic pathway hemostasis oxidoreductase activity platelet activation metal ion binding oxidation-reduction process uc009tpt.1 uc009tpt.2 uc009tpt.3 uc009tpt.4 uc009tpt.5 
ENSMUST00000033540.6 Vbp1 ENSMUST00000033540.6 von Hippel-Lindau binding protein 1 (from RefSeq NM_011692.2) ENSMUST00000033540.1 ENSMUST00000033540.2 ENSMUST00000033540.3 ENSMUST00000033540.4 ENSMUST00000033540.5 NM_011692 O55228 P61759 PFD3_MOUSE Pfdn3 Q15765 Q3U6M9 Q9CPZ0 uc009tqd.1 uc009tqd.2 uc009tqd.3 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL. Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus. Belongs to the prefoldin subunit alpha family. Sequence=AAC23908.1; Type=Erroneous initiation; Evidence=; nucleus cytoplasm cytosol polysome protein folding microtubule-based process tubulin complex assembly tubulin binding prefoldin complex intracellular membrane-bounded organelle uc009tqd.1 uc009tqd.2 uc009tqd.3 
ENSMUST00000033541.5 Fundc2 ENSMUST00000033541.5 FUN14 domain containing 2 (from RefSeq NM_026126.4) ENSMUST00000033541.1 ENSMUST00000033541.2 ENSMUST00000033541.3 ENSMUST00000033541.4 FUND2_MOUSE Fundc2 Hcbp6 NM_026126 Q80VT2 Q80YD9 Q8BSM8 Q9D617 Q9D6K8 uc009tpu.1 uc009tpu.2 uc009tpu.3 uc009tpu.4 Binds directly and specifically 1,2-Diacyl-sn-glycero-3- phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:30576423, PubMed:29786068). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (By similarity). Mitochondrion outer membrane ; Multi-pass membrane protein Nucleus Highly expressed in platelet (at protein level) (PubMed:29786068, PubMed:30576423). Expressed in liver, brain, heart and muscle (PubMed:29786068). Belongs to the FUN14 family. mitophagy molecular_function mitochondrion integral component of mitochondrial outer membrane uc009tpu.1 uc009tpu.2 uc009tpu.3 uc009tpu.4 
ENSMUST00000033542.11 Mtcp1 ENSMUST00000033542.11 mature T cell proliferation 1 (from RefSeq NM_001039373.5) A3KGA7 C6.1b ENSMUST00000033542.1 ENSMUST00000033542.10 ENSMUST00000033542.2 ENSMUST00000033542.3 ENSMUST00000033542.4 ENSMUST00000033542.5 ENSMUST00000033542.6 ENSMUST00000033542.7 ENSMUST00000033542.8 ENSMUST00000033542.9 MTCP1_MOUSE NM_001039373 Q60945 uc009tpw.1 uc009tpw.2 uc009tpw.3 uc009tpw.4 Enhances the phosphorylation and activation of AKT1 and AKT2. Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=2; Synonyms=Long, Type B1, p13 MTCP-1; IsoId=Q60945-1; Sequence=Displayed; Name=1; Synonyms=Short, Type A, p8 MTCP-1; IsoId=Q61908-1; Sequence=External; Not found at a significant level in any tissue. [Isoform 2]: Shares a non-coding 5' exon with isoform 1 which is spliced to a different set of 3' exons encoding an unrelated protein. Belongs to the TCL1 family. mitochondrion protein kinase binding macromolecular complex positive regulation of peptidyl-serine phosphorylation protein serine/threonine kinase activator activity positive regulation of protein serine/threonine kinase activity uc009tpw.1 uc009tpw.2 uc009tpw.3 uc009tpw.4 
ENSMUST00000033543.14 Cmc4 ENSMUST00000033543.14 C-X9-C motif containing 4, transcript variant 1 (from RefSeq NM_010839.6) C6.1b CMC4_MOUSE ENSMUST00000033543.1 ENSMUST00000033543.10 ENSMUST00000033543.11 ENSMUST00000033543.12 ENSMUST00000033543.13 ENSMUST00000033543.2 ENSMUST00000033543.3 ENSMUST00000033543.4 ENSMUST00000033543.5 ENSMUST00000033543.6 ENSMUST00000033543.7 ENSMUST00000033543.8 ENSMUST00000033543.9 Mtcp1 NM_010839 Q61908 uc009tpv.1 uc009tpv.2 uc009tpv.3 uc009tpv.4 Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Short, Type A, p8 MTCP-1; IsoId=Q61908-1; Sequence=Displayed; Name=2; Synonyms=Long, Type B1, p13 MTCP-1; IsoId=Q60945-1; Sequence=External; Expressed in many tissues. The twin Cx9C motifs are involved in the recognition by the mitochondrial disulfide relay system. [Isoform 1]: Shares a non-coding 5' exon with isoform 2 which is spliced to a different set of 3' exons encoding an unrelated protein. Belongs to the CMC4 family. mitochondrion mitochondrial intermembrane space uc009tpv.1 uc009tpv.2 uc009tpv.3 uc009tpv.4 
ENSMUST00000033544.14 Brcc3 ENSMUST00000033544.14 BRCA1/BRCA2-containing complex, subunit 3, transcript variant 2 (from RefSeq NM_145956.4) A3KGA9 A8Y5K0 BRCC3_MOUSE Brcc36 C6.1a ENSMUST00000033544.1 ENSMUST00000033544.10 ENSMUST00000033544.11 ENSMUST00000033544.12 ENSMUST00000033544.13 ENSMUST00000033544.2 ENSMUST00000033544.3 ENSMUST00000033544.4 ENSMUST00000033544.5 ENSMUST00000033544.6 ENSMUST00000033544.7 ENSMUST00000033544.8 ENSMUST00000033544.9 NM_145956 P46737 Q3UDZ4 Q9D025 uc009tqa.1 uc009tqa.2 uc009tqa.3 Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:23246432, PubMed:34180153). Does not have activity toward 'Lys-48'-linked polyubiquitin chains (By similarity). Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) (By similarity). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (By similarity). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (By similarity). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (By similarity). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (By similarity). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (By similarity). Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (PubMed:23246432, PubMed:28943315). Down- regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (By similarity). Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (PubMed:34180153). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Note=Binds 1 zinc ion per subunit. ; Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin (By similarity). Interacts with PWWP2B (PubMed:34180153). Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B (PubMed:34180153). Nucleus Cytoplasm Cytoplasm, cytoskeleton, spindle pole Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). Interaction with ABRAXAS2 retains BRCC3 in the cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P46737-1; Sequence=Displayed; Name=2; IsoId=P46737-2; Sequence=VSP_037260; Belongs to the peptidase M67A family. BRCC36 subfamily. ubiquitin ligase complex nuclear ubiquitin ligase complex spindle pole thiol-dependent ubiquitin-specific protease activity protein binding nucleus nucleoplasm cytoplasm cytoskeleton DNA repair double-strand break repair chromatin organization proteolysis cellular response to DNA damage stimulus cell cycle peptidase activity metallopeptidase activity response to X-ray response to ionizing radiation hydrolase activity enzyme regulator activity polyubiquitin binding thiol-dependent ubiquitinyl hydrolase activity positive regulation of DNA repair metal ion binding regulation of catalytic activity cell division BRCA1-A complex protein K63-linked deubiquitination histone H2A K63-linked deubiquitination BRISC complex signal transduction involved in G2 DNA damage checkpoint uc009tqa.1 uc009tqa.2 uc009tqa.3 
ENSMUST00000033545.6 Rab39b ENSMUST00000033545.6 RAB39B, member RAS oncogene family (from RefSeq NM_175122.6) ENSMUST00000033545.1 ENSMUST00000033545.2 ENSMUST00000033545.3 ENSMUST00000033545.4 ENSMUST00000033545.5 NM_175122 Q3TUJ3 Q8BHC1 RB39B_MOUSE uc009tqe.1 uc009tqe.2 uc009tqe.3 uc009tqe.4 This gene encodes a member of the Ras-related small GTPases, which regulate membrane trafficking in organelles and transport vesicles. This protein has been reported to be enriched in mouse brain, and specifically within neurons, and may play a role in synapse formation. In humans mutations in this gene are associated with X-linked cognitive disability. [provided by RefSeq, Jun 2013]. ##Evidence-Data-START## Transcript exon combination :: BY257784.1, BC050853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). May be involved in vesicular trafficking (PubMed:20159109). Plays a role in synapse formation. May regulate the homeostasis of SNCA/alpha-synuclein (PubMed:25434005). Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission (PubMed:25784538). Interacts (in GTP-bound form) with PICK1 (via PDZ domain); a PICK1 homodimer may allow simultaneous association of RAB39B and GRIA2 to PICK1 which is involved in GRIA2 trafficking. Interacts with isoform c of RASSF1; the interaction is strong (PubMed:23294242). Interacts with isoform a of RASSF1; the interaction is weak (PubMed:23294242). Interacts with the DLG4/PSD-95 (PubMed:31651360). Q8BHC1; Q8CGB3-3: Uaca; NbExp=4; IntAct=EBI-10767682, EBI-10767725; Cell membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasmic vesicle membrane ; Lipid-anchor ; Cytoplasmic side Golgi apparatus Note=Partial colocalization with markers that cycle from the cell surface to the trans-Golgi network. Specifically expressed in neuron and neuronal precursors in the brain. Expression is high in all regions of the brain with highest levels observed in the hippocampus. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity protein binding GTP binding Golgi apparatus plasma membrane intracellular protein transport autophagy regulation of autophagy protein transport membrane vesicle-mediated transport cytoplasmic vesicle membrane cytoplasmic vesicle myosin V binding vesicle Rab protein signal transduction neuron projection synapse organization uc009tqe.1 uc009tqe.2 uc009tqe.3 uc009tqe.4 
ENSMUST00000033549.3 Asb12 ENSMUST00000033549.3 ankyrin repeat and SOCS box-containing 12, transcript variant 2 (from RefSeq NM_080858.3) ASB12_MOUSE ENSMUST00000033549.1 ENSMUST00000033549.2 NM_080858 Q9D738 uc009tty.1 uc009tty.2 uc009tty.3 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Interacts with CUL5 and RNF7. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Belongs to the ankyrin SOCS box (ASB) family. ubiquitin ligase complex protein ubiquitination ubiquitin protein ligase activity uc009tty.1 uc009tty.2 uc009tty.3 
ENSMUST00000033553.14 Heph ENSMUST00000033553.14 hephaestin, transcript variant 1 (from RefSeq NM_010417.2) A2AI63 ENSMUST00000033553.1 ENSMUST00000033553.10 ENSMUST00000033553.11 ENSMUST00000033553.12 ENSMUST00000033553.13 ENSMUST00000033553.2 ENSMUST00000033553.3 ENSMUST00000033553.4 ENSMUST00000033553.5 ENSMUST00000033553.6 ENSMUST00000033553.7 ENSMUST00000033553.8 ENSMUST00000033553.9 HEPH_MOUSE Kiaa0698 NM_010417 Q6ZQ65 Q80Y80 Q8C4S2 Q9Z0Z4 uc009tuk.1 uc009tuk.2 uc009tuk.3 uc009tuk.4 uc009tuk.5 May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1. Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Note=Binds 6 Cu cations per monomer. ; Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z0Z4-1; Sequence=Displayed; Name=2; IsoId=Q9Z0Z4-2; Sequence=VSP_011628; Note=Defects in Heph are a cause of the sex-linked anemia (sla) that is characterized by moderate to severe microcytic hypochronic anemia. Belongs to the multicopper oxidase family. Sequence=BAC98004.1; Type=Erroneous initiation; Evidence=; ferroxidase activity copper ion binding plasma membrane ion transport copper ion transport iron ion transport cellular iron ion homeostasis ferrous iron binding membrane integral component of membrane basolateral plasma membrane oxidoreductase activity metal ion binding perinuclear region of cytoplasm iron ion homeostasis oxidation-reduction process uc009tuk.1 uc009tuk.2 uc009tuk.3 uc009tuk.4 uc009tuk.5 
ENSMUST00000033554.6 Gpr165 ENSMUST00000033554.6 G protein-coupled receptor 165 (from RefSeq NM_029536.3) ENSMUST00000033554.1 ENSMUST00000033554.2 ENSMUST00000033554.3 ENSMUST00000033554.4 ENSMUST00000033554.5 Gpr165 NM_029536 Q3V3A3 Q3V3A3_MOUSE uc009tuq.1 uc009tuq.2 uc009tuq.3 uc009tuq.4 uc009tuq.5 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane uc009tuq.1 uc009tuq.2 uc009tuq.3 uc009tuq.4 uc009tuq.5 
ENSMUST00000033556.4 Pgr15l ENSMUST00000033556.4 G protein-coupled receptor 15-like (from RefSeq NM_001033361.3) ENSMUST00000033556.1 ENSMUST00000033556.2 ENSMUST00000033556.3 NM_001033361 Pgr15l Q80T54 Q80T54_MOUSE uc009tur.1 uc009tur.2 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity neuropeptide Y receptor activity integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway membrane integral component of membrane non-motile cilium uc009tur.1 uc009tur.2 
ENSMUST00000033560.9 Ophn1 ENSMUST00000033560.9 oligophrenin 1, transcript variant 1 (from RefSeq NM_052976.4) ENSMUST00000033560.1 ENSMUST00000033560.2 ENSMUST00000033560.3 ENSMUST00000033560.4 ENSMUST00000033560.5 ENSMUST00000033560.6 ENSMUST00000033560.7 ENSMUST00000033560.8 NM_052976 OPHN1_MOUSE Q544K7 Q99J31 uc009tuy.1 uc009tuy.2 uc009tuy.3 uc009tuy.4 Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity). Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation. Interacts with HOMER1. Interacts with AMPA receptor complexes. Interacts with SH3GL2 (endophilin-A1) (By similarity). Interacts (via C-terminus) with NR1D1. Postsynapse Presynapse Cell projection, axon Cell projection, dendritic spine Cell projection, dendrite Cytoplasm Note=Present in both presynaptic and postsynaptic sites. actin binding GTPase activator activity protein binding phospholipid binding cytoplasm endocytosis signal transduction nervous system development actin cytoskeleton cerebellar granule cell differentiation cerebral cortex neuron differentiation actin cytoskeleton organization cell junction regulation of endocytosis neuron differentiation axon dendrite neuron projection development cell junction assembly regulation of Rho protein signal transduction ionotropic glutamate receptor binding cell projection terminal bouton dendritic spine positive regulation of GTPase activity establishment of epithelial cell apical/basal polarity synapse synaptic vesicle endocytosis cell morphogenesis involved in neuron differentiation regulation of synaptic transmission, glutamatergic maintenance of postsynaptic specialization structure glutamatergic synapse negative regulation of proteasomal protein catabolic process uc009tuy.1 uc009tuy.2 uc009tuy.3 uc009tuy.4 
ENSMUST00000033567.15 Awat2 ENSMUST00000033567.15 acyl-CoA wax alcohol acyltransferase 2, transcript variant 1 (from RefSeq NM_177746.4) AWAT2_MOUSE Dgat2l4 ENSMUST00000033567.1 ENSMUST00000033567.10 ENSMUST00000033567.11 ENSMUST00000033567.12 ENSMUST00000033567.13 ENSMUST00000033567.14 ENSMUST00000033567.2 ENSMUST00000033567.3 ENSMUST00000033567.4 ENSMUST00000033567.5 ENSMUST00000033567.6 ENSMUST00000033567.7 ENSMUST00000033567.8 ENSMUST00000033567.9 NM_177746 Q6E1M8 Q8BM49 Ws uc009tvx.1 uc009tvx.2 uc009tvx.3 uc009tvx.4 Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349). Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donor and acceptor, respectively (PubMed:15220349). Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis- specific retinyl ester synthesis (PubMed:28096191). Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13- cis-retinol and all-trans-retinol substrates (By similarity). Reaction=a fatty acyl-CoA + a long chain fatty alcohol = a wax ester + CoA; Xref=Rhea:RHEA:38443, ChEBI:CHEBI:10036, ChEBI:CHEBI:17135, ChEBI:CHEBI:57287, ChEBI:CHEBI:77636; EC=2.3.1.75; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38444; Evidence=; Reaction=all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA; Xref=Rhea:RHEA:11488, ChEBI:CHEBI:17336, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:63410; EC=2.3.1.76; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11489; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1- hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA; Xref=Rhea:RHEA:38071, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:73990, ChEBI:CHEBI:75466; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38072; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2- di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA; Xref=Rhea:RHEA:38163, ChEBI:CHEBI:52333, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75583; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38164; Evidence=; Reaction=hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoate; Xref=Rhea:RHEA:38167, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75584; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38168; Evidence=; Reaction=hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA; Xref=Rhea:RHEA:38171, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75586, ChEBI:CHEBI:75587; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38172; Evidence=; Reaction=all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA; Xref=Rhea:RHEA:38175, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38176; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219, ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38220; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9Z)-octadecenoate; Xref=Rhea:RHEA:38227, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75622; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38228; Evidence=; Reaction=(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)- hexadecenyl (9Z)-octadecenoate + CoA; Xref=Rhea:RHEA:38231, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75623, ChEBI:CHEBI:75624; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + octadecan-1-ol = 1-O-octadecyl (9Z)- octadecenoate + CoA; Xref=Rhea:RHEA:38235, ChEBI:CHEBI:32154, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75625; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38236; Evidence=; Reaction=(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)- octadecenyl (9Z)-octadecenoate + CoA; Xref=Rhea:RHEA:38239, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:73504, ChEBI:CHEBI:75626; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38240; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + hexadecan-1-ol = 1-O-hexadecyl (9Z)- hexadecenoate + CoA; Xref=Rhea:RHEA:38247, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:75629; Evidence=; Reaction=hexadecan-1-ol + octadecanoyl-CoA = CoA + hexadecanyl octadecanoate; Xref=Rhea:RHEA:38251, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:75631; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38252; Evidence=; Reaction=11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA; Xref=Rhea:RHEA:55324, ChEBI:CHEBI:16254, ChEBI:CHEBI:16302, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55325; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O- (9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:55340, ChEBI:CHEBI:34116, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:197429; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55341; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:37915, ChEBI:CHEBI:52323, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37916; Evidence=; Reaction=11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA; Xref=Rhea:RHEA:55272, ChEBI:CHEBI:16302, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:138676; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55273; Evidence=; Reaction=9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA; Xref=Rhea:RHEA:55276, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:78272, ChEBI:CHEBI:138691; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55277; Evidence=; Reaction=13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA; Xref=Rhea:RHEA:55280, ChEBI:CHEBI:45479, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:138704; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55281; Evidence=; Reaction=all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA; Xref=Rhea:RHEA:55284, ChEBI:CHEBI:17336, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:138718; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55285; Evidence=; Reaction=tetradecan-1-ol + tetradecanoyl-CoA = CoA + tetradecanyl tetradecanoate; Xref=Rhea:RHEA:55288, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:77417, ChEBI:CHEBI:138721; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55289; Evidence=; 11-cis retinoids act as allosteric modulators of acyl-CoA retinol O-fatty-acyltransferase (ARAT) activity by suppressing esterification of 9-cis, 13-cis, or all-trans retinols concurrently increasing the enzyme specificity toward 11-cis isomer. Kinetic parameters: KM=26.22 uM for 11-cis-retinol ; KM=22.25 uM for 9-cis-retinol ; KM=24.32 uM for 9-cis-retinol (in the presence of 2 uM of 11-cis- retinyl palmitate) ; KM=21.87 uM for 9-cis-retinol (in the presence of 4 uM of 11-cis- retinyl palmitate) ; KM=18.74 uM for 9-cis-retinol (in the presence of 6 uM of 11-cis- retinyl palmitate) ; KM=15.26 uM for 9-cis-retinol (in the presence of 10 uM of 11-cis- retinyl palmitate) ; KM=35.18 uM for 13-cis-retinol ; KM=23.59 uM for all-trans-retinol ; Vmax=14.52 nmol/min/mg enzyme for 11-cis-retinol ; Vmax=4.53 nmol/min/mg enzyme for 9-cis-retinol ; Vmax=3.81 nmol/min/mg enzyme for 9-cis-retinol (in the presence of 2 uM of 11-cis-retinyl palmitate) ; Vmax=2.61 nmol/min/mg enzyme for 9-cis-retinol (in the presence of 4 uM of 11-cis-retinyl palmitate) ; Vmax=1.82 nmol/min/mg enzyme for 9-cis-retinol (in the presence of 6 uM of 11-cis-retinyl palmitate) ; Vmax=0.96 nmol/min/mg enzyme for 9-cis-retinol (in the presence of 10 uM of 11-cis-retinyl palmitate) ; Vmax=1.06 nmol/min/mg enzyme for 13-cis-retinol ; Vmax=0.66 nmol/min/mg enzyme for all-trans-retinol ; Monomer. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6E1M8-1; Sequence=Displayed; Name=2; IsoId=Q6E1M8-2; Sequence=VSP_020357; Expressed in Mueller cells of the retina (at protein level) (PubMed:24799687). Abundant in tissues rich in sebaceous glands such as the preputial gland and eyelid (PubMed:15220349). Belongs to the diacylglycerol acyltransferase family. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process wax biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups retinol metabolic process long-chain-alcohol O-fatty-acyltransferase activity retinol O-fatty-acyltransferase activity uc009tvx.1 uc009tvx.2 uc009tvx.3 uc009tvx.4 
ENSMUST00000033570.6 Igbp1 ENSMUST00000033570.6 immunoglobulin (CD79A) binding protein 1 (from RefSeq NM_008784.3) ENSMUST00000033570.1 ENSMUST00000033570.2 ENSMUST00000033570.3 ENSMUST00000033570.4 ENSMUST00000033570.5 IGBP1_MOUSE NM_008784 Pc52 Q61249 uc009tvz.1 uc009tvz.2 uc009tvz.3 Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. Interacts with PPP2CB, and with PP4 and PP6. Interacts with MID2. Interacts with ubiquitin (By similarity). Interacts with partially folded PPP2CA, but not with the fully active protein. Interacts with MID1. Q61249; P63330: Ppp2ca; NbExp=2; IntAct=EBI-7002233, EBI-397144; Q61249; P67775: PPP2CA; Xeno; NbExp=3; IntAct=EBI-7002233, EBI-712311; Cytoplasm Expressed in spleen, thymus, liver and brain. Ubiquitously expressed in B lineage cell lines. The UIM domain is required for protective effect on PP2A. Phosphorylated. Monoubiquitination by MID1 triggers calpain-mediated cleavage and switches IGBP1 activity from protective to destructive. Belongs to the IGBP1/TAP42 family. negative regulation of transcription from RNA polymerase II promoter protein binding cytoplasm cytosol microtubule regulation of signal transduction protein phosphatase regulator activity protein domain specific binding mitogen-activated protein kinase kinase binding negative regulation of stress-activated MAPK cascade response to tumor necrosis factor positive regulation of dephosphorylation negative regulation of protein dephosphorylation B cell activation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of phosphoprotein phosphatase activity macromolecular complex binding positive regulation of transcription from RNA polymerase II promoter protein phosphatase 2A binding regulation of microtubule-based movement response to interleukin-1 negative regulation of apoptotic signaling pathway uc009tvz.1 uc009tvz.2 uc009tvz.3 
ENSMUST00000033575.7 Magee2 ENSMUST00000033575.7 MAGE family member E2 (from RefSeq NM_053206.2) ENSMUST00000033575.1 ENSMUST00000033575.2 ENSMUST00000033575.3 ENSMUST00000033575.4 ENSMUST00000033575.5 ENSMUST00000033575.6 Magee2 NM_053206 Q52KG3 Q52KG3_MOUSE uc009uak.1 uc009uak.2 molecular_function cellular_component biological_process uc009uak.1 uc009uak.2 
ENSMUST00000033577.11 Pbdc1 ENSMUST00000033577.11 polysaccharide biosynthesis domain containing 1, transcript variant 1 (from RefSeq NM_026312.5) B1AUP5 ENSMUST00000033577.1 ENSMUST00000033577.10 ENSMUST00000033577.2 ENSMUST00000033577.3 ENSMUST00000033577.4 ENSMUST00000033577.5 ENSMUST00000033577.6 ENSMUST00000033577.7 ENSMUST00000033577.8 ENSMUST00000033577.9 NM_026312 PBDC1_MOUSE Q8C5Z2 Q9CVL0 Q9D0B6 uc009uat.1 uc009uat.2 uc009uat.3 uc009uat.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D0B6-1; Sequence=Displayed; Name=2; IsoId=Q9D0B6-2; Sequence=VSP_021180; Belongs to the PBDC1 family. molecular_function biological_process uc009uat.1 uc009uat.2 uc009uat.3 uc009uat.4 
ENSMUST00000033578.7 Magee1 ENSMUST00000033578.7 MAGE family member E1 (from RefSeq NM_053201.4) ENSMUST00000033578.1 ENSMUST00000033578.2 ENSMUST00000033578.3 ENSMUST00000033578.4 ENSMUST00000033578.5 ENSMUST00000033578.6 MAGE1_MOUSE NM_053201 Q6PCZ4 Q8BG82 Q8BQ37 Q99PB2 uc009uav.1 uc009uav.2 uc009uav.3 uc009uav.4 May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). Interacts with DTNA. Interacts with TRIM28 (By similarity). Cytoplasm, perinuclear region Nucleus Cell membrane Note=In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane. Expressed in cell bodies and dendrites of hippocampal and Purkinje neurons. Also expressed in peripheral nerve, where it localizes to the perineurium and myelin (at protein level). Predominantly expressed in brain and at low levels in the heart, liver, kidney, spleen, testis, lung, thymus, placenta and skeletal muscle. Sequence=BAC26750.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC34694.1; Type=Frameshift; Evidence=; Sequence=BAC38206.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=EDL14072.1; Type=Erroneous gene model prediction; Evidence=; protein binding nucleus cytoplasm plasma membrane biological_process membrane dendrite postsynaptic membrane perinuclear region of cytoplasm uc009uav.1 uc009uav.2 uc009uav.3 uc009uav.4 
ENSMUST00000033581.4 Fgf16 ENSMUST00000033581.4 fibroblast growth factor 16 (from RefSeq NM_030614.2) A2RTU5 ENSMUST00000033581.1 ENSMUST00000033581.2 ENSMUST00000033581.3 FGF16_MOUSE NM_030614 Q9ERQ5 Q9ESL8 uc009uba.1 uc009uba.2 uc009uba.3 Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Interacts with FGFR1 and FGFR2. Secreted Belongs to the heparin-binding growth factors family. fibroblast growth factor receptor binding extracellular region growth factor activity fibroblast growth factor receptor signaling pathway positive regulation of brown fat cell proliferation positive regulation of endothelial cell chemotaxis to fibroblast growth factor uc009uba.1 uc009uba.2 uc009uba.3 
ENSMUST00000033582.5 Cox7b ENSMUST00000033582.5 cytochrome c oxidase subunit 7B (from RefSeq NM_025379.2) Cox7b ENSMUST00000033582.1 ENSMUST00000033582.2 ENSMUST00000033582.3 ENSMUST00000033582.4 NM_025379 Q5FW98 Q5FW98_MOUSE uc009ubk.1 uc009ubk.2 Energy metabolism; oxidative phosphorylation. Membrane ; Single- pass membrane protein Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the cytochrome c oxidase VIIb family. cytochrome-c oxidase activity mitochondrial respiratory chain central nervous system development electron transport chain hydrogen ion transmembrane transport uc009ubk.1 uc009ubk.2 
ENSMUST00000033585.7 Pgk2 ENSMUST00000033585.7 phosphoglycerate kinase 2 (from RefSeq NM_031190.2) ENSMUST00000033585.1 ENSMUST00000033585.2 ENSMUST00000033585.3 ENSMUST00000033585.4 ENSMUST00000033585.5 ENSMUST00000033585.6 NM_031190 P09041 PGK2_MOUSE Pgk-2 Q5RKV3 Q6P8V2 uc008cof.1 uc008cof.2 uc008cof.3 uc008cof.4 Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis (PubMed:19759366). Reaction=(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP; Xref=Rhea:RHEA:14801, ChEBI:CHEBI:30616, ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216; EC=2.7.2.3; Evidence=; Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 2/5. Monomer. Cytoplasm Testis and sperm. Localized on the principle piece in the sperm (at protein level). Testis-specific. Mice display greatly reduced ATP levels in sperm, severely impaired sperm motility and are infertile. No alteration in testis histology, sperm counts, or sperm ultrastructure seen. Belongs to the phosphoglycerate kinase family. nucleotide binding phosphoglycerate kinase activity ATP binding cytoplasm cytosol cilium gluconeogenesis glycolytic process kinase activity phosphorylation transferase activity flagellated sperm motility sperm fibrous sheath ADP binding positive regulation of oxidative phosphorylation uc008cof.1 uc008cof.2 uc008cof.3 uc008cof.4 
ENSMUST00000033591.6 Itm2a ENSMUST00000033591.6 integral membrane protein 2A (from RefSeq NM_008409.2) E25 ENSMUST00000033591.1 ENSMUST00000033591.2 ENSMUST00000033591.3 ENSMUST00000033591.4 ENSMUST00000033591.5 ITM2A_MOUSE Itm2 NM_008409 Q3TJP5 Q61500 Q8K0H4 Q9CRW4 uc009ucg.1 uc009ucg.2 uc009ucg.3 Membrane ; Single-pass type II membrane protein Expressed in mandibular condyles, in bone and in hair follicles. Strong expression in osteogenic tissues, such as neonatal calvaria, paws, tail and skin. Belongs to the ITM2 family. beta-amyloid binding plasma cell differentiation immunoglobulin production Golgi apparatus plasma membrane membrane integral component of membrane negative regulation of amyloid precursor protein biosynthetic process uc009ucg.1 uc009ucg.2 uc009ucg.3 
ENSMUST00000033597.9 Hmgn5 ENSMUST00000033597.9 high-mobility group nucleosome binding domain 5 (from RefSeq NM_016710.2) ENSMUST00000033597.1 ENSMUST00000033597.2 ENSMUST00000033597.3 ENSMUST00000033597.4 ENSMUST00000033597.5 ENSMUST00000033597.6 ENSMUST00000033597.7 ENSMUST00000033597.8 Garp45 HMGN5_MOUSE NM_016710 Nsbp1 O88832 Q3V272 Q8VC71 Q9CUW1 Q9JL35 uc009ucs.1 uc009ucs.2 uc009ucs.3 Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. Nucleus te=Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin. Expressed in liver, spleen, lung, heart, kidney, muscle and brain (at protein level). Widely expressed with highest levels in submaxillary gland, thymus, kidney and liver and lowest levels in brain, lung, pancreas and eye. At 7.5 dpc, expression is detected in the ectoplacental cone but not in embryonic tissues. By 9.5 dpc and 12.5 dpc, strongly expressed in the giant trophoblast, spongiotrophoblast and decidual cells of the placenta (at protein level). At 9.5 dpc and 11.5 dpc, weakly expressed in the developing embryo. Specifically targeted by its C-terminus to nucleosomes in euchromatin. Belongs to the HMGN family. chromatin DNA binding chromatin binding nucleus nucleoplasm chromatin organization regulation of transcription from RNA polymerase II promoter glutathione metabolic process nucleosomal DNA binding uc009ucs.1 uc009ucs.2 uc009ucs.3 
ENSMUST00000033598.9 Sh3bgrl ENSMUST00000033598.9 SH3-binding domain glutamic acid-rich protein like (from RefSeq NM_019989.2) A2ALN7 ENSMUST00000033598.1 ENSMUST00000033598.2 ENSMUST00000033598.3 ENSMUST00000033598.4 ENSMUST00000033598.5 ENSMUST00000033598.6 ENSMUST00000033598.7 ENSMUST00000033598.8 NM_019989 Q3UB57 Q9JJU8 SH3L1_MOUSE uc009uct.1 uc009uct.2 uc009uct.3 Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs. Monomer. Interacts with PFN1/Profilin-1. Interacts with ERBB2. Interacts with ATG12. Interacts with BECN1. Interacts with translating ribosomes. Cytoplasm, cytosol Cell membrane The SH3-binding domain is buried in the tertiary structure, and it therefore unclear whether it directly mediates protein-binding. Belongs to the SH3BGR family. molecular_function biological_process SH3 domain binding uc009uct.1 uc009uct.2 uc009uct.3 
ENSMUST00000033602.9 Tnmd ENSMUST00000033602.9 tenomodulin (from RefSeq NM_022322.2) Chm1l ENSMUST00000033602.1 ENSMUST00000033602.2 ENSMUST00000033602.3 ENSMUST00000033602.4 ENSMUST00000033602.5 ENSMUST00000033602.6 ENSMUST00000033602.7 ENSMUST00000033602.8 NM_022322 Q8CET4 Q9EP64 TNMD_MOUSE uc009uez.1 uc009uez.2 uc009uez.3 uc009uez.4 uc009uez.5 May be an angiogenesis inhibitor. Membrane ; Single-pass type II membrane protein Nucleus envelope Widely expressed with highest expression in tendons and ligaments, in the diaphragm, eye and skeletal muscle. Expressed in neuronal cells of all brain regions. Very low expression, if any, in glial cells. Expression already detected at 9.5 dpc and maintained throughout embryonic development. At 17.5 dpc, high levels found in tendons and ligaments of the skeletomuscular system, including the knee joint, the upper limb and the intercostal ligaments. At this developmental stage, high expression is also detected in the tendinous part of the diaphragm. By contrast, low levels are observed in resting and proliferative chondrocytes of long bones and vertebral bodies, and in the cartilaginous part of the intervertebral disks. No expression in hypertrophic chondrocytes. Outside the skeletomuscular system, expressed in neuronal cells of all brain regions and the spinal cord, liver, lung, bowels, thymus and eye. Belongs to the chondromodulin-1 family. Sequence=BAC25447.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; endothelial cell morphogenesis negative regulation of endothelial cell proliferation nucleus nuclear envelope membrane integral component of membrane negative regulation of angiogenesis negative regulation of vascular endothelial growth factor receptor signaling pathway tendon cell differentiation cellular response to BMP stimulus uc009uez.1 uc009uez.2 uc009uez.3 uc009uez.4 uc009uez.5 
ENSMUST00000033608.15 Sytl4 ENSMUST00000033608.15 synaptotagmin-like 4, transcript variant 1 (from RefSeq NM_013757.2) B1AVI8 B1AVI9 ENSMUST00000033608.1 ENSMUST00000033608.10 ENSMUST00000033608.11 ENSMUST00000033608.12 ENSMUST00000033608.13 ENSMUST00000033608.14 ENSMUST00000033608.2 ENSMUST00000033608.3 ENSMUST00000033608.4 ENSMUST00000033608.5 ENSMUST00000033608.6 ENSMUST00000033608.7 ENSMUST00000033608.8 ENSMUST00000033608.9 NM_013757 Q8R321 Q9R0Q0 Q9R0Q1 SYTL4_MOUSE Slp4 uc009ufe.1 uc009ufe.2 uc009ufe.3 Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner. Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B. Interacts with MYO5A. Q9R0Q1-1; Q9ERI2: Rab27a; NbExp=2; IntAct=EBI-15734647, EBI-398172; Membrane ; Peripheral membrane protein Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Granuphilin-a; IsoId=Q9R0Q1-1; Sequence=Displayed; Name=2; Synonyms=Granuphilin-b; IsoId=Q9R0Q1-2; Sequence=VSP_007900, VSP_007901; Name=3; IsoId=Q9R0Q1-3; Sequence=VSP_007902; Detected in the pancreatic islet, in particular in insulin-positive beta cells, and in pituitary. [Isoform 3]: May be due to an intron retention. plasma membrane repair protein binding phospholipid binding nucleoplasm endosome microtubule organizing center cytosol intracellular protein transport exocytosis zinc ion binding membrane apical plasma membrane Rab GTPase binding extrinsic component of membrane secretory granule transport vesicle membrane secretory granule membrane cytoplasmic vesicle lysosome localization neurexin family protein binding positive regulation of exocytosis negative regulation of insulin secretion metal ion binding positive regulation of protein secretion exocytic vesicle multivesicular body sorting pathway regulation of plasma membrane repair uc009ufe.1 uc009ufe.2 uc009ufe.3 
ENSMUST00000033609.9 Cstf2 ENSMUST00000033609.9 cleavage stimulation factor, 3' pre-RNA subunit 2, transcript variant 1 (from RefSeq NM_133196.6) A2AEJ9 A2AEK0 CSTF2_MOUSE ENSMUST00000033609.1 ENSMUST00000033609.2 ENSMUST00000033609.3 ENSMUST00000033609.4 ENSMUST00000033609.5 ENSMUST00000033609.6 ENSMUST00000033609.7 ENSMUST00000033609.8 NM_133196 Q8BIQ5 Q8K1Y6 Q9ERC2 uc009ufj.1 uc009ufj.2 uc009ufj.3 uc009ufj.4 One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF2 directly interacts with CSTF3, SYMPK and RPO2TC1. Interacts with HSF1 in heat-stressed cells (By similarity). Interacts with CPSF2, CPSF3 and FIP1L1. Interacts with DDX1 (By similarity). Nucleus Note=Localized with DDX1 in cleavage bodies. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BIQ5-1; Sequence=Displayed; Name=2; IsoId=Q8BIQ5-2; Sequence=VSP_014844, VSP_014845; Expressed in most somatic cell types (at protein level). Highly expressed in testis, except in meiotic spermatocytes. Up-regulated during the G to S phase transition. nucleic acid binding RNA binding mRNA binding nucleus nucleoplasm mRNA cleavage and polyadenylation specificity factor complex mRNA polyadenylation mRNA processing nuclear body mRNA 3'-end processing cleavage body pre-mRNA cleavage required for polyadenylation cellular response to nerve growth factor stimulus uc009ufj.1 uc009ufj.2 uc009ufj.3 uc009ufj.4 
ENSMUST00000033610.13 Nox1 ENSMUST00000033610.13 NADPH oxidase 1 (from RefSeq NM_172203.2) A2AEK5 ENSMUST00000033610.1 ENSMUST00000033610.10 ENSMUST00000033610.11 ENSMUST00000033610.12 ENSMUST00000033610.2 ENSMUST00000033610.3 ENSMUST00000033610.4 ENSMUST00000033610.5 ENSMUST00000033610.6 ENSMUST00000033610.7 ENSMUST00000033610.8 ENSMUST00000033610.9 NM_172203 NOX1_MOUSE Q0KKX3 Q0KKX5 Q811U2 Q8CIZ9 uc009ufl.1 uc009ufl.2 uc009ufl.3 This gene encodes a subunit of the NADPH oxidase enzyme, which is a membrane-bound, multisubunit protein. This complex catalyzes the transfer of electrons from NADPH to molecular oxygen to produce superoxide or hydrogen peroxide and may have a role in antimicrobial killing and cell signaling. This protein binds other subunits in order to produce superoxide. In mouse, deficiency of this enzyme may be associated with changes in blood pressure. [provided by RefSeq, Jun 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK136432.1, AF539799.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849389 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## [Isoform 1]: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. [Isoform 2]: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. [Isoform 1]: Reaction=NADPH + 2 O2 = H(+) + NADP(+) + 2 superoxide; Xref=Rhea:RHEA:63180, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18421, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; [Isoform 2]: Reaction=NADPH + 2 O2 = H(+) + NADP(+) + 2 superoxide; Xref=Rhea:RHEA:63180, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18421, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; [Isoform 2]: The oxidase activity is potentiated by NOXA1 and NOXO1. NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interacts with NOXO1. Interacts (via FAD-binding FR-type domain) with ARHGEF7 (via PH domain) (By similarity). Interacts with NOXA1 (PubMed:16814099). Cell projection, invadopodium membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=f-type, c-type; IsoId=Q8CIZ9-1; Sequence=Displayed; Name=2; Synonyms=a-type; IsoId=Q8CIZ9-2; Sequence=VSP_038574; Name=3; IsoId=Q8CIZ9-3; Sequence=VSP_038574, VSP_038575; [Isoform 2]: Expressed in colon and vascular smooth muscle cells (VSMC). [Isoform 1]: (c-type) induced in VSMC by angiotensin II and injury to the artery. Phosphorylation at Thr-457 mediated by PKC/PRKBC positively regulates its interaction with NOXA1 and enzyme activity. [Isoform 1]: Product of f-type and c-type mRNA, which differ only in 5'-UTR. response to reactive oxygen species angiogenesis regulation of systemic arterial blood pressure by renin-angiotensin cytoplasm endosome early endosome plasma membrane defense response signal transduction positive regulation of cell proliferation positive regulation of vascular endothelial growth factor production membrane integral component of membrane superoxide-generating NADPH oxidase activity cell migration oxidoreductase activity cell junction extracellular matrix organization superoxide anion generation hydrogen peroxide metabolic process cell projection NADPH oxidase complex positive regulation of MAPK cascade positive regulation of integrin biosynthetic process positive regulation of JNK cascade metal ion binding Rac GTPase binding positive regulation of smooth muscle cell proliferation intracellular pH elevation oxidation-reduction process invadopodium membrane cellular response to hyperoxia oxygen metabolic process positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway cellular stress response to acidic pH positive regulation of reactive oxygen species metabolic process uc009ufl.1 uc009ufl.2 uc009ufl.3 
ENSMUST00000033611.5 Xkrx ENSMUST00000033611.5 X-linked Kx blood group related, X-linked, transcript variant 1 (from RefSeq NM_183319.3) A2AEK6 ENSMUST00000033611.1 ENSMUST00000033611.2 ENSMUST00000033611.3 ENSMUST00000033611.4 NM_183319 Q5GH68 XKR2_MOUSE Xkr2 Xrg2 uc009ufo.1 uc009ufo.2 uc009ufo.3 Membrane ; Multi-pass membrane protein Belongs to the XK family. molecular_function cellular_component biological_process membrane integral component of membrane uc009ufo.1 uc009ufo.2 uc009ufo.3 
ENSMUST00000033617.13 Btk ENSMUST00000033617.13 Bruton agammaglobulinemia tyrosine kinase (from RefSeq NM_013482.2) BTK_MOUSE Bpk ENSMUST00000033617.1 ENSMUST00000033617.10 ENSMUST00000033617.11 ENSMUST00000033617.12 ENSMUST00000033617.2 ENSMUST00000033617.3 ENSMUST00000033617.4 ENSMUST00000033617.5 ENSMUST00000033617.6 ENSMUST00000033617.7 ENSMUST00000033617.8 ENSMUST00000033617.9 NM_013482 P35991 Q61365 uc009uge.1 uc009uge.2 uc009uge.3 uc009uge.4 Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:7538439, PubMed:8629002, PubMed:10852954). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B- cell activation (By similarity). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (By similarity). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (By similarity). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (By similarity). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:17725607). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (By similarity). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (By similarity). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (By similarity). BTK also plays a critical role in transcription regulation (By similarity). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (By similarity). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa- B (By similarity). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:11120822, PubMed:16738337). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:11120822, PubMed:16738337). ARID3A and NFAT are other transcriptional target of BTK (PubMed:11120822, PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:11120822, PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:11120822, PubMed:16738337). BTK has a dual role in the regulation of apoptosis (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Activated by phosphorylation. In primary B lymphocytes, is almost always non-phosphorylated and is thus catalytically inactive. Stimulation of TLR8 and TLR9 causes BTK activation. As a negative feedback mechanism to fine-tune BCR signaling, activated PRKCB down-modulates BTK function via direct phosphorylation of BTK at Ser-180, resulting in translocation of BTK back to the cytoplasmic fraction. PIN1, SH3BP5, and IBTK were also identified as BTK activity inhibitors. Interaction with CAV1 leads to dramatic down-regulation of the kinase activity of BTK. LFM-13A is a specific inhibitor of BTK. Dasatinib, a cancer drug acting as a tyrosine kinase inhibitor, also blocks BTK activity. Part of a complex composed of EEIG1, TNFRSF11A/RANK, PLCG2, GAB2, TEC and BTK; complex formation increases in the presence of TNFSF11/RANKL (PubMed:23478294). Binds GTF2I through the PH domain. Interacts with SH3BP5 via the SH3 domain. Interacts with IBTK via its PH domain. Interacts with ARID3A, CAV1, FASLG, PIN1, TLR8 and TLR9. P35991; P27512: Cd40; NbExp=3; IntAct=EBI-625119, EBI-525742; P35991; Q60631: Grb2; NbExp=4; IntAct=EBI-625119, EBI-1688; P35991; P22366: Myd88; NbExp=2; IntAct=EBI-625119, EBI-525108; P35991; Q80UF7: Ticam1; NbExp=2; IntAct=EBI-625119, EBI-3649271; Cytoplasm Cell membrane ; Peripheral membrane protein Nucleus Membrane raft Note=In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1. The PH domain mediates the binding to inositol polyphosphate and phosphoinositides, leading to its targeting to the plasma membrane. It is extended in the BTK kinase family by a region designated the TH (Tec homology) domain, which consists of about 80 residues preceding the SH3 domain. Following B-cell receptor (BCR) engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-551 by LYN and SYK. Phosphorylation at Tyr-551 is followed by autophosphorylation of Tyr- 223 which may create a docking site for a SH2 containing protein. Phosphorylation at Ser-180 by PRKCB, leads in translocation of BTK back to the cytoplasmic fraction. Phosphorylation at Ser-21 and Ser-115 creates a binding site for PIN1 at these Ser-Pro motifs, and promotes it's recruitment (By similarity). Note=Defects in Btk are the cause of murine X-linked immunodeficiency (XID). Prevents BCR-induced activation of NF-kappa-B. Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. nucleotide binding positive regulation of type III hypersensitivity positive regulation of type I hypersensitivity negative regulation of cytokine production adaptive immune response B cell affinity maturation immune system process histamine secretion by mast cell protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding phosphatidylinositol-3,4,5-trisphosphate binding nucleus cytoplasm cytosol plasma membrane protein phosphorylation apoptotic process I-kappaB kinase/NF-kappaB signaling lipid binding response to organic substance membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation negative regulation of B cell proliferation cytoplasmic vesicle cellular response to reactive oxygen species intracellular signal transduction mast cell granule identical protein binding innate immune response membrane raft protein autophosphorylation metal ion binding cell maturation perinuclear region of cytoplasm cellular response to molecule of fungal origin cellular response to interleukin-7 uc009uge.1 uc009uge.2 uc009uge.3 uc009uge.4 
ENSMUST00000033626.15 Serpina7 ENSMUST00000033626.15 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7, transcript variant 1 (from RefSeq NM_177920.5) ENSMUST00000033626.1 ENSMUST00000033626.10 ENSMUST00000033626.11 ENSMUST00000033626.12 ENSMUST00000033626.13 ENSMUST00000033626.14 ENSMUST00000033626.2 ENSMUST00000033626.3 ENSMUST00000033626.4 ENSMUST00000033626.5 ENSMUST00000033626.6 ENSMUST00000033626.7 ENSMUST00000033626.8 ENSMUST00000033626.9 NM_177920 Q3UEL9 Q3UEL9_MOUSE Serpina7 uc009ukb.1 uc009ukb.2 uc009ukb.3 uc009ukb.4 uc009ukb.5 Major thyroid hormone transport protein in serum. Belongs to the serpin family. extracellular space thyroid hormone transport uc009ukb.1 uc009ukb.2 uc009ukb.3 uc009ukb.4 uc009ukb.5 
ENSMUST00000033634.5 Acsl4 ENSMUST00000033634.5 acyl-CoA synthetase long-chain family member 4, transcript variant 1 (from RefSeq NM_207625.2) ACSL4_MOUSE Acs4 ENSMUST00000033634.1 ENSMUST00000033634.2 ENSMUST00000033634.3 ENSMUST00000033634.4 Facl4 NM_207625 Q5D071 Q9JHT4 Q9QUJ7 Q9R0H3 uc009ulu.1 uc009ulu.2 Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl- CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:456215; EC=6.2.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19714; Evidence=; Reaction=15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15- hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52116, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:78832, ChEBI:CHEBI:136409, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52117; Evidence=; Reaction=12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12- hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52112, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:90718, ChEBI:CHEBI:136408, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52113; Evidence=; Reaction=5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5- hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52108, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65341, ChEBI:CHEBI:136407, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52109; Evidence=; Reaction=5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 5,6- epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52088, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:131992, ChEBI:CHEBI:136351, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52089; Evidence=; Reaction=14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15- epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52016, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:84024, ChEBI:CHEBI:136117, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52017; Evidence=; Reaction=11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12- epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52012, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:76625, ChEBI:CHEBI:136115, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52013; Evidence=; Reaction=8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 8,9- epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52008, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:84025, ChEBI:CHEBI:136107, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52009; Evidence=; Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl- CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30752; Evidence=; Reaction=(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:36139, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61526, ChEBI:CHEBI:72745, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36140; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Both triacsin C and rosiglitazone inhibit arachidonoyl-CoA ligase activity. Mitochondrion outer membrane ; Single-pass type III membrane protein Peroxisome membrane ; Single-pass type III membrane protein Microsome membrane ; Single-pass type III membrane protein Endoplasmic reticulum membrane ; Single-pass type III membrane protein Cell membrane Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q9QUJ7-1; Sequence=Displayed; Name=Short; IsoId=Q9QUJ7-2; Sequence=VSP_000239; Abundant in steroidogenic tissues, also found in the kidney, brain and liver. Induced by adrenocorticotropic hormone (ACTH) and suppressed by glucocorticoid. Belongs to the ATP-dependent AMP-binding enzyme family. nucleotide binding long-chain fatty acid metabolic process catalytic activity acyl-CoA ligase activity long-chain fatty acid-CoA ligase activity ATP binding cytoplasm mitochondrion mitochondrial outer membrane peroxisome peroxisomal membrane endoplasmic reticulum endoplasmic reticulum membrane lipid particle plasma membrane lipid metabolic process fatty acid metabolic process response to nutrient lipid biosynthetic process fatty acid transport membrane integral component of membrane ligase activity regulation of fatty acid metabolic process triglyceride biosynthetic process neuron differentiation positive regulation of cell growth organelle membrane very long-chain fatty acid-CoA ligase activity mitochondrial membrane positive regulation of insulin secretion negative regulation of prostaglandin secretion long-chain fatty-acyl-CoA biosynthetic process neuronal cell body intracellular membrane-bounded organelle ER-mitochondrion membrane contact site arachidonate-CoA ligase activity embryonic process involved in female pregnancy dendritic spine development response to interleukin-15 decanoate--CoA ligase activity uc009ulu.1 uc009ulu.2 
ENSMUST00000033643.6 Glt28d2 ENSMUST00000033643.6 glycosyltransferase 28 domain containing 2 (from RefSeq NM_177130.3) ENSMUST00000033643.1 ENSMUST00000033643.2 ENSMUST00000033643.3 ENSMUST00000033643.4 ENSMUST00000033643.5 Glt28d2 NM_177130 Q8BML3 Q8BML3_MOUSE uc008pqx.1 uc008pqx.2 uc008pqx.3 uc008pqx.4 Reaction=N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N- acetyl-alpha-D-glucosamine = H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP; Xref=Rhea:RHEA:23380, Rhea:RHEA-COMP:9519, Rhea:RHEA-COMP:9520, ChEBI:CHEBI:15378, ChEBI:CHEBI:57269, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:58427; EC=2.4.1.141; Evidence=; Belongs to the glycosyltransferase 28 family. dolichol-linked oligosaccharide biosynthetic process transferase activity transferase activity, transferring hexosyl groups uc008pqx.1 uc008pqx.2 uc008pqx.3 uc008pqx.4 
ENSMUST00000033646.9 Il13ra2 ENSMUST00000033646.9 interleukin 13 receptor, alpha 2, transcript variant 1 (from RefSeq NM_008356.4) A3F812 ENSMUST00000033646.1 ENSMUST00000033646.2 ENSMUST00000033646.3 ENSMUST00000033646.4 ENSMUST00000033646.5 ENSMUST00000033646.6 ENSMUST00000033646.7 ENSMUST00000033646.8 I13R2_MOUSE NM_008356 O88786 Q3V2V5 uc009ung.1 uc009ung.2 uc009ung.3 This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. Binds as a monomer with high affinity to interleukin-13 (IL13). O88786; Q61362: Chi3l1; NbExp=12; IntAct=EBI-20260800, EBI-8392424; O88786; P20109: Il13; NbExp=4; IntAct=EBI-20260800, EBI-20559598; O88786; P16110: Lgals3; NbExp=2; IntAct=EBI-20260800, EBI-3508325; [Isoform 1]: Membrane; Single-pass type I membrane protein. [Isoform 2]: Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88786-1; Sequence=Displayed; Name=2; IsoId=O88786-2; Sequence=VSP_037588, VSP_037589; The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. Belongs to the type I cytokine receptor family. Type 5 subfamily. negative regulation of immunoglobulin production cytokine receptor activity protein binding extracellular region external side of plasma membrane membrane integral component of membrane immunoglobulin mediated immune response cytokine-mediated signaling pathway cytokine binding receptor complex negative regulation of mast cell degranulation uc009ung.1 uc009ung.2 uc009ung.3 
ENSMUST00000033650.14 Rs1 ENSMUST00000033650.14 retinoschisis (X-linked, juvenile) 1 (human) (from RefSeq NM_011302.3) ENSMUST00000033650.1 ENSMUST00000033650.10 ENSMUST00000033650.11 ENSMUST00000033650.12 ENSMUST00000033650.13 ENSMUST00000033650.2 ENSMUST00000033650.3 ENSMUST00000033650.4 ENSMUST00000033650.5 ENSMUST00000033650.6 ENSMUST00000033650.7 ENSMUST00000033650.8 ENSMUST00000033650.9 NM_011302 Q9Z1L4 Rs1h XLRS1_MOUSE Xlrs1 uc009utq.1 uc009utq.2 Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (PubMed:17325137, PubMed:20677810). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (By similarity). Required for normal structure and function of the retina (PubMed:11983912, PubMed:17325137). Homooctamer of 4 homodimers; disulfide-linked. The homooctamer has a flat, cogwheel structure with a diameter of about 14 nm. Two stacked octamers can assemble to form a hexadecamer. Secreted Cell membrane ; Peripheral membrane protein xtracellular side Note=Binds to phosphatidylserine-containing lipid membranes and embeds itself partially into the lipid bilayer. Lipid-binding requires the presence of Ca(2+) ions. Detected in the eye cup (PubMed:11983912). Detected in retina, in the inner segment of the photoreceptors, the inner nuclear layer, the inner plexiform layer and the ganglion cell layer (at protein level) (PubMed:10915776, PubMed:11983912, PubMed:17325137). Restricted to the retina (PubMed:10023077, PubMed:10915776). At the mRNA level, detected only within the photoreceptor cell layer, most prominently within the inner segments of the photoreceptors (PubMed:10023077, PubMed:10915776). Undetectable in the inner plexiform layers and the inner nuclear layer (PubMed:10915776). No visible phenotype at birth (PubMed:11983912). After two months, mutant males display a profound disorganization of the inner and outer nuclear layer of the retina, with increased extracellular spaces in the region of photoreceptor ribbon synapses and the appearance of gaps, and a decrease in the number of photoreceptor cell outer segments (PubMed:11983912, PubMed:17325137). The number of cone photoreceptors is reduced threefold (PubMed:11983912). After three months, mutant males display a layer of small, cyst-like structures in the inner retina (PubMed:11983912). They have profoundly altered electroretinograms, indicating a decreased light sensitivity due to a decrease in the number of functional photoreceptors (PubMed:11983912). phosphatidylserine binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding extracellular region extracellular space plasma membrane cell adhesion visual perception lipid binding phosphatidylinositol-5-phosphate binding retina layer formation membrane adaptation of rhodopsin mediated signaling extrinsic component of plasma membrane phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,4-bisphosphate binding response to stimulus protein homooligomerization phosphatidylinositol-4-phosphate binding phosphatidylinositol-3,5-bisphosphate binding phosphatidylethanolamine binding phosphatidylcholine binding uc009utq.1 uc009utq.2 
ENSMUST00000033662.9 Pdha1 ENSMUST00000033662.9 pyruvate dehydrogenase E1 alpha 1 (from RefSeq NM_008810.3) ENSMUST00000033662.1 ENSMUST00000033662.2 ENSMUST00000033662.3 ENSMUST00000033662.4 ENSMUST00000033662.5 ENSMUST00000033662.6 ENSMUST00000033662.7 ENSMUST00000033662.8 NM_008810 Pdha1 Q3UFJ3 Q3UFJ3_MOUSE uc009utc.1 uc009utc.2 uc009utc.3 uc009utc.4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Reaction=H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate = CO2 + N(6)-[(R)-S(8)- acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase]; Xref=Rhea:RHEA:19189, Rhea:RHEA-COMP:10480, Rhea:RHEA-COMP:10481, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:83099, ChEBI:CHEBI:83111; EC=1.2.4.1; Evidence= Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence= pyruvate dehydrogenase activity pyruvate dehydrogenase (acetyl-transferring) activity nucleolus mitochondrion acetyl-CoA biosynthetic process from pyruvate tricarboxylic acid cycle oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor intracellular membrane-bounded organelle pyruvate dehydrogenase complex oxidation-reduction process uc009utc.1 uc009utc.2 uc009utc.3 uc009utc.4 
ENSMUST00000033664.14 Il2rg ENSMUST00000033664.14 interleukin 2 receptor, gamma chain, transcript variant a (from RefSeq NM_013563.4) ENSMUST00000033664.1 ENSMUST00000033664.10 ENSMUST00000033664.11 ENSMUST00000033664.12 ENSMUST00000033664.13 ENSMUST00000033664.2 ENSMUST00000033664.3 ENSMUST00000033664.4 ENSMUST00000033664.5 ENSMUST00000033664.6 ENSMUST00000033664.7 ENSMUST00000033664.8 ENSMUST00000033664.9 Il2rg NM_013563 Q3UPA9 Q3UPA9_MOUSE uc009txc.1 uc009txc.2 uc009txc.3 uc009txc.4 This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through this pathway in important in immune cell differentiation and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. Belongs to the type I cytokine receptor family. Type 5 subfamily. cytokine receptor activity membrane integral component of membrane cytokine-mediated signaling pathway uc009txc.1 uc009txc.2 uc009txc.3 uc009txc.4 
ENSMUST00000033665.9 Map3k15 ENSMUST00000033665.9 mitogen-activated protein kinase kinase kinase 15 (from RefSeq NM_001163085.4) A2AQW0 ENSMUST00000033665.1 ENSMUST00000033665.2 ENSMUST00000033665.3 ENSMUST00000033665.4 ENSMUST00000033665.5 ENSMUST00000033665.6 ENSMUST00000033665.7 ENSMUST00000033665.8 M3K15_MOUSE Map3k15 NM_001163085 uc009utb.1 uc009utb.2 uc009utb.3 Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway. Once activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases. May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis. Involved in phosphorylation of WNK4 in response to osmotic stress or hypotonic low-chloride stimulation via the p38 MAPK signal transduction cascade. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-816, inhibited by phosphorylation at Ser-928 (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. MAPK cascade nucleotide binding activation of MAPKK activity protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity ATP binding protein phosphorylation kinase activity phosphorylation transferase activity metal ion binding uc009utb.1 uc009utb.2 uc009utb.3 
ENSMUST00000033671.13 Rps6ka3 ENSMUST00000033671.13 ribosomal protein S6 kinase polypeptide 3, transcript variant 1 (from RefSeq NM_148945.2) B1AXN4 ENSMUST00000033671.1 ENSMUST00000033671.10 ENSMUST00000033671.11 ENSMUST00000033671.12 ENSMUST00000033671.2 ENSMUST00000033671.3 ENSMUST00000033671.4 ENSMUST00000033671.5 ENSMUST00000033671.6 ENSMUST00000033671.7 ENSMUST00000033671.8 ENSMUST00000033671.9 KS6A3_MOUSE Mapkapk1b NM_148945 P18654 Q03140 Q8K3J8 Rps6ka-rs1 Rsk2 uc009usk.1 uc009usk.2 uc009usk.3 uc009usk.4 Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1 (PubMed:10856237, PubMed:15109498). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (By similarity). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (By similarity). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (By similarity). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (By similarity). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (By similarity). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin- sensitive signaling independently of the PI3K/AKT pathway (By similarity). Mediates cell survival by phosphorylating the pro- apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (By similarity). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:14504289). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3- mediated transformation signaling, after direct phosphorylation at Tyr- 529 by FGFR3 (PubMed:17785202, PubMed:17906627). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (PubMed:22827337). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (PubMed:22827337). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (By similarity). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (PubMed:15109498). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-577 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-386, allowing binding of PDPK1, which in turn phosphorylates Ser- 227 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD (By similarity). Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). Interacts with NFATC4, ETV1/ER81 and FGFR1 (By similarity). P18654; P30309: cdc25-1-b; Xeno; NbExp=3; IntAct=EBI-397744, EBI-15888737; P18654; P28223-1: HTR2A; Xeno; NbExp=2; IntAct=EBI-397744, EBI-15573967; Nucleus Cytoplasm Intestine, thymus, lung, heart and brain. Activated by phosphorylation at Ser-227 by PDPK1. Autophosphorylated on Ser-386, as part of the activation process. May be phosphorylated at Thr-365 and Ser-369 by MAPK1/ERK2 and MAPK3/ERK1. Can also be activated via phosphorylation at Ser-386 by MAPKAPK2. N-terminal myristoylation results in an activated kinase in the absence of added growth factors. Mice were born at expected Mendelian ratio but display decreased bone mass (PubMed:15109498). Embryos and pups show a delay in mineralization of the skull with frontal, parietal, and interparietal bones of reduced size (PubMed:15109498). Mice also display a significant reduction in long bone length at one month of age (PubMed:15109498). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. nucleotide binding magnesium ion binding toll-like receptor signaling pathway protein kinase activity protein serine/threonine kinase activity ribosomal protein S6 kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm protein phosphorylation apoptotic process cell cycle kinase activity phosphorylation transferase activity protein kinase binding response to lipopolysaccharide intracellular signal transduction cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of transcription from RNA polymerase II promoter uc009usk.1 uc009usk.2 uc009usk.3 uc009usk.4 
ENSMUST00000033673.7 Nono ENSMUST00000033673.7 non-POU-domain-containing, octamer binding protein, transcript variant 1 (from RefSeq NM_023144.3) ENSMUST00000033673.1 ENSMUST00000033673.2 ENSMUST00000033673.3 ENSMUST00000033673.4 ENSMUST00000033673.5 ENSMUST00000033673.6 NM_023144 NONO_MOUSE Nono Q63887 Q99K48 Q9CYQ4 Q9DBP2 uc009txs.1 uc009txs.2 uc009txs.3 uc009txs.4 DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA (PubMed:8355702). Also binds single-stranded DNA and RNA at a site independent of the duplex site (By similarity). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (By similarity). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (By similarity). Together with PSPC1, required for the formation of nuclear paraspeckles (By similarity). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (By similarity). The SFPQ- NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (By similarity). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (By similarity). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (By similarity). NONO is involved in transcriptional regulation (By similarity). The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP- dependent transcriptional activity (By similarity). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (PubMed:9001221). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (PubMed:22966205). Important for the functional organization of GABAergic synapses (PubMed:26571461). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (PubMed:26571461). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (PubMed:32286661). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity). Monomer and component of the SFPQ-NONO complex, which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits. NONO is a component of spliceosome and U5.4/6 snRNP complexes (By similarity). Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Forms heterodimers with PSPC1; this involves formation of a coiled coil domain by helices from both proteins (PubMed:15140795). Part of complex consisting of SFPQ, NONO and MATR3. Part of a complex consisting of SFPQ, NONO and NR5A1. Part of a complex consisting of SFPQ, NONO and TOP1. Interacts with SPI1 and SPIB (PubMed:8626664). Interacts with RNF43 (By similarity). Interacts with PER1 and PER2 (PubMed:22966205). Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA. Interacts (via second RRM domain) with WASL; the interaction is direct. Component of a multiprotein complex with WASL and SFPQ (By similarity). Interacts with ERCC6 (By similarity). Interacts (via DNA-binding domain) with TET1 (PubMed:32286661). Q99K48; A0A087WPF7: Auts2; NbExp=4; IntAct=EBI-607499, EBI-27122375; Q99K48; P17433: Spi1; NbExp=3; IntAct=EBI-607499, EBI-607588; Nucleus cleus, nucleolus Nucleus speckle Chromosome Note=Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99K48-1; Sequence=Displayed; Name=2; IsoId=Q99K48-2; Sequence=VSP_013981; Expressed in liver and suprachiasmatic nuclei, hippocampus and neocortex (at protein level). Expression is strongest in neurons in CA1 and CA3 pyramidal regions and granule cells of the dentate gyrus. Detected in testis and kidney. Mutant mice display flattened nose and a smaller cerebellum. Behaviorally, mice show impaired spatial memory, as well as a marked anxiety phenotype and increased risk aversion (PubMed:26571461). Deletion leads to a significant dissociation of TET1 from chromatin and dysregulation of DNA hydroxymethylation of neuronal genes (PubMed:32286661). Sequence=BAB23598.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAB28857.1; Type=Frameshift; Evidence=; transcription regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding activation of innate immune response immune system process nucleic acid binding DNA binding chromatin binding RNA binding protein binding nucleus nucleoplasm nucleolus DNA repair DNA recombination mRNA processing cellular response to DNA damage stimulus circadian rhythm RNA splicing nuclear matrix nuclear speck paraspeckles regulation of circadian rhythm identical protein binding innate immune response negative regulation of transcription, DNA-templated rhythmic process E-box binding RNA polymerase II transcription factor complex negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway uc009txs.1 uc009txs.2 uc009txs.3 uc009txs.4 
ENSMUST00000033674.6 Itgb1bp2 ENSMUST00000033674.6 integrin beta 1 binding protein 2, transcript variant 1 (from RefSeq NM_013712.3) ENSMUST00000033674.1 ENSMUST00000033674.2 ENSMUST00000033674.3 ENSMUST00000033674.4 ENSMUST00000033674.5 ITBP2_MOUSE NM_013712 Q9D161 Q9R000 uc009txu.1 uc009txu.2 uc009txu.3 May play a role during maturation and/or organization of muscles cells. Interacts with beta-1 integrin subunit. This interaction is regulated by divalent cations, and it occurs only in absence of calcium. Q9R000; Q9CS74: Ecd; NbExp=2; IntAct=EBI-7922331, EBI-7922565; Q9R000; P07901: Hsp90aa1; NbExp=5; IntAct=EBI-7922331, EBI-78930; Expressed in skeletal and cardiac muscles but not in other tissues. Is localized in rows flanking the Z line containing alpha-actinin. Detectable in embryo limbs at day 15, reached a maximum in newborn, and declined in adult limb muscles. During heart development level remains steady from embryonic day 15 to adult stage. During muscle regeneration. The tail domain binds to the cytoplasmic domain of both integrin beta-1a and beta-1d isoforms. The presence of Ca(2+) ions does not prevent binding of a fragment consisting of the second cysteine rich repeat and the tail domain but prevents the binding of the full- length protein. integrin binding calcium ion binding protein binding zinc ion binding SH3 domain binding Z disc metal ion binding uc009txu.1 uc009txu.2 uc009txu.3 
ENSMUST00000033683.8 Rps4x ENSMUST00000033683.8 ribosomal protein S4, X-linked, transcript variant 2 (from RefSeq NM_009094.3) ENSMUST00000033683.1 ENSMUST00000033683.2 ENSMUST00000033683.3 ENSMUST00000033683.4 ENSMUST00000033683.5 ENSMUST00000033683.6 ENSMUST00000033683.7 NM_009094 Q545X8 Q545X8_MOUSE Rps4x uc009tym.1 uc009tym.2 uc009tym.3 uc009tym.4 uc009tym.5 Belongs to the eukaryotic ribosomal protein eS4 family. RNA binding structural constituent of ribosome ribosome polysome translation multicellular organism development positive regulation of cell proliferation small ribosomal subunit rRNA binding cytosolic small ribosomal subunit cytoplasmic ribonucleoprotein granule response to ethanol positive regulation of translation ribonucleoprotein complex uc009tym.1 uc009tym.2 uc009tym.3 uc009tym.4 uc009tym.5 
ENSMUST00000033689.3 Cdx4 ENSMUST00000033689.3 caudal type homeobox 4 (from RefSeq NM_007674.3) Cdx4 ENSMUST00000033689.1 ENSMUST00000033689.2 NM_007674 Q78Z64 Q78Z64_MOUSE uc009tzk.1 uc009tzk.2 uc009tzk.3 Nucleus Belongs to the Caudal homeobox family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc009tzk.1 uc009tzk.2 uc009tzk.3 
ENSMUST00000033691.5 Tsx ENSMUST00000033691.5 testis specific X-linked gene, transcript variant 1 (from RefSeq NM_009440.3) ENSMUST00000033691.1 ENSMUST00000033691.2 ENSMUST00000033691.3 ENSMUST00000033691.4 NM_009440 Q78Z65 Q78Z65_MOUSE Tsx uc009tzm.1 uc009tzm.2 uc009tzm.3 uc009tzm.4 uc009tzm.1 uc009tzm.2 uc009tzm.3 uc009tzm.4 
ENSMUST00000033692.9 Zcchc13 ENSMUST00000033692.9 zinc finger, CCHC domain containing 13 (from RefSeq NM_029158.3) Cnbp2 ENSMUST00000033692.1 ENSMUST00000033692.2 ENSMUST00000033692.3 ENSMUST00000033692.4 ENSMUST00000033692.5 ENSMUST00000033692.6 ENSMUST00000033692.7 ENSMUST00000033692.8 NM_029158 Q9D548 Q9D548_MOUSE Zcchc13 uc009tzx.1 uc009tzx.2 uc009tzx.3 nucleic acid binding single-stranded RNA binding mRNA binding cytoplasm zinc ion binding translation regulator activity positive regulation of cytoplasmic translation uc009tzx.1 uc009tzx.2 uc009tzx.3 
ENSMUST00000033695.6 Abcb7 ENSMUST00000033695.6 ATP-binding cassette, sub-family B member 7 (from RefSeq NM_009592.1) A2AC46 ABCB7_MOUSE Abc7 Abcb7 ENSMUST00000033695.1 ENSMUST00000033695.2 ENSMUST00000033695.3 ENSMUST00000033695.4 ENSMUST00000033695.5 NM_009592 Q3U7S8 Q61102 uc009uaf.1 uc009uaf.2 uc009uaf.3 uc009uaf.4 Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP- dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (PubMed:16424901, PubMed:16467350). Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (PubMed:17192398). Reaction=(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O = (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:67028, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:167627, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67029; Evidence=; Homodimer or heterodimer. Interacts with C10orf88/PAAT (By similarity). Forms a complex with ABCB10 and FECH, where a dimeric FECH bridges ABCB7 and ABCB10 homodimers; this complex may be required for cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). Interacts with FECH (PubMed:30765471). Interacts with ATP5F1A. Interacts with COX4I1; this interaction allows the regulation of cellular iron homeostasis and cellular reactive oxygen species (ROS) levels in cardiomyocytes (By similarity). Mitochondrion inner membrane ; Multi-pass membrane protein Heterozygous females for Abcb7 with a maternally inherited mutant allele die embryonically, due to a defect in the extra-embryonic visceral endoderm, while heterozygous females with a paternally inherited mutant allele are viable (PubMed:16467350). The systemic and tissue-specific deletion of ABCB7 in most organs, including CNS and bone marrow, is lethal (PubMed:16467350). Conditional knockout in hepatocyte causes periportal hepatocellular iron deposition with characteristic round structures and leads to iron-dependent regulation of IRP1 protein (PubMed:16467350, PubMed:16424901). Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. nucleotide binding ATP binding mitochondrion mitochondrial inner membrane cellular iron ion homeostasis membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances transmembrane transport uc009uaf.1 uc009uaf.2 uc009uaf.3 uc009uaf.4 
ENSMUST00000033711.6 Gabrq ENSMUST00000033711.6 gamma-aminobutyric acid type A receptor subunit theta, transcript variant 2 (from RefSeq NM_020488.2) ENSMUST00000033711.1 ENSMUST00000033711.2 ENSMUST00000033711.3 ENSMUST00000033711.4 ENSMUST00000033711.5 GBRT_MOUSE NM_020488 Q9JLF1 uc009tkq.1 uc009tkq.2 uc009tkq.3 uc009tkq.4 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1. Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub- subfamily. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction gamma-aminobutyric acid signaling pathway chemical synaptic transmission membrane integral component of membrane cell junction ion transmembrane transport chloride channel complex regulation of membrane potential neuron projection receptor complex synapse postsynaptic membrane neurological system process chloride transmembrane transport uc009tkq.1 uc009tkq.2 uc009tkq.3 uc009tkq.4 
ENSMUST00000033715.5 Nsdhl ENSMUST00000033715.5 NAD(P) dependent steroid dehydrogenase-like (from RefSeq NM_010941.3) ENSMUST00000033715.1 ENSMUST00000033715.2 ENSMUST00000033715.3 ENSMUST00000033715.4 NM_010941 NSDHL_MOUSE O55109 Q9R1J0 uc009tkv.1 uc009tkv.2 uc009tkv.3 Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (PubMed:10369263, PubMed:14567972). Plays a role in the regulation of the endocytic trafficking of EGFR (PubMed:23125191). Reaction=a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3- oxosteroid + CO2 + NADPH; Xref=Rhea:RHEA:34771, ChEBI:CHEBI:16526, ChEBI:CHEBI:47788, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:136966; EC=1.1.1.170; Evidence=; Reaction=a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3- oxosteroid + CO2 + NADH; Xref=Rhea:RHEA:34775, ChEBI:CHEBI:16526, ChEBI:CHEBI:47788, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:136966; EC=1.1.1.170; Evidence=; Reaction=4alpha-carboxyzymosterol + NADP(+) = CO2 + NADPH + zymosterone; Xref=Rhea:RHEA:33455, ChEBI:CHEBI:16526, ChEBI:CHEBI:52386, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:143575; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33456; Evidence=; Reaction=4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH; Xref=Rhea:RHEA:46828, ChEBI:CHEBI:16526, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:87047, ChEBI:CHEBI:87050; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46829; Evidence=; Reaction=4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) = 5alpha-cholest-8-en-3-one + CO2 + NADPH; Xref=Rhea:RHEA:46848, ChEBI:CHEBI:16526, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:87055, ChEBI:CHEBI:87056; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46849; Evidence=; Reaction=4beta-methylzymosterol-4alpha-carboxylate + NADP(+) = 3- dehydro-4-methylzymosterol + CO2 + NADPH; Xref=Rhea:RHEA:33447, ChEBI:CHEBI:16526, ChEBI:CHEBI:50593, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:64925; EC=1.1.1.170; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33448; Evidence=; Reaction=4beta-methylzymosterol-4alpha-carboxylate + NAD(+) = 3- dehydro-4-methylzymosterol + CO2 + NADH; Xref=Rhea:RHEA:47160, ChEBI:CHEBI:16526, ChEBI:CHEBI:50593, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:64925; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47161; Evidence=; Reaction=4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) = 5alpha-cholest-8-en-3-one + CO2 + NADH; Xref=Rhea:RHEA:47172, ChEBI:CHEBI:16526, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:87055, ChEBI:CHEBI:87056; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47173; Evidence=; Reaction=4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH; Xref=Rhea:RHEA:47168, ChEBI:CHEBI:16526, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:87047, ChEBI:CHEBI:87050; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47169; Evidence=; Reaction=4alpha-carboxyzymosterol + NAD(+) = CO2 + NADH + zymosterone; Xref=Rhea:RHEA:47164, ChEBI:CHEBI:16526, ChEBI:CHEBI:52386, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:143575; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47165; Evidence=; Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6. Homodimer. Endoplasmic reticulum membrane ; Single-pass membrane protein Lipid droplet Note=Trafficking through the Golgi is necessary for ER membrane localization. Note=Defects in Nsdhl are the cause of male-lethal mutations bare patches (Bpa) and striated (Str) phenotypes. Heterozygous Bpa females are dwarfed and demonstrate abnormal deposits of calcium in tail vertebrae. They also develop a hyperkeratotic skin eruption shortly after birth that resolves, leaving 'bare patches' arranged in a horizontal, striped pattern. The Str females are indistinguishable from normal littermates until postnatal day 12-14 when they develop striations in their coat. Belongs to the 3-beta-HSD family. hair follicle development 3-beta-hydroxy-delta5-steroid dehydrogenase activity endoplasmic reticulum endoplasmic reticulum membrane lipid particle lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process smoothened signaling pathway steroid metabolic process cholesterol metabolic process membrane integral component of membrane sterol biosynthetic process oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity oxidation-reduction process labyrinthine layer blood vessel development uc009tkv.1 uc009tkv.2 uc009tkv.3 
ENSMUST00000033720.12 Rbbp7 ENSMUST00000033720.12 retinoblastoma binding protein 7, chromatin remodeling factor (from RefSeq NM_009031.3) A2AFJ0 ENSMUST00000033720.1 ENSMUST00000033720.10 ENSMUST00000033720.11 ENSMUST00000033720.2 ENSMUST00000033720.3 ENSMUST00000033720.4 ENSMUST00000033720.5 ENSMUST00000033720.6 ENSMUST00000033720.7 ENSMUST00000033720.8 ENSMUST00000033720.9 NM_009031 Q3UX20 Q60973 RBBP7_MOUSE Rbap46 uc009uug.1 uc009uug.2 uc009uug.3 uc009uug.4 Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity). Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin (By similarity). Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1 (By similarity). Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex (By similarity). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:27806305). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:27806305). The NuRD complex may interact with MBD3L1. The NuRD complex may interact with MBD3L2 (By similarity). Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12 (PubMed:20144788). The PRC2/EED-EZH2 complex may also associate with HDAC1. Component of the NURF-1 ISWI chromatin remodeling complex (also called the nucleosome-remodeling factor (NURF) complex) at least composed of SMARCA1, BPTF, RBBP4 and RBBP7. Within the complex interacts with SMARCA1. Component of the BPFT-SMARCA1 complex at least composed of SMARCA1, BPFT, RBBP4 and RBBP7; the complex is catalytically inactive and does not remodel chromatin. Within the complex interacts with SMARCA1. Interacts with BRCA1. Interacts with CDK2AP1. Interacts with CENPA. Interacts with CHD3. Interacts with CHD4. Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP (By similarity). Interacts with HDAC7 (PubMed:10984530). Interacts with MTA1 (By similarity). Interacts with PWWP2B (PubMed:34180153). Interacts with RB1 (via viral protein-binding domain) (By similarity). Interacts with SUV39H1 (PubMed:11788710). Nucleus. Higher levels in brain, thymus, lung, spleen, kidney, testis, and ovary/uterus; lower levels in heart, liver, and muscle. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. negative regulation of transcription from RNA polymerase II promoter RNA binding protein binding nucleus nucleoplasm cytosol DNA replication chromatin organization chromatin remodeling NuRD complex negative regulation of cell growth ESC/E(Z) complex negative regulation of transcription, DNA-templated response to steroid hormone cellular heat acclimation uc009uug.1 uc009uug.2 uc009uug.3 uc009uug.4 
ENSMUST00000033723.4 Syap1 ENSMUST00000033723.4 synapse associated protein 1 (from RefSeq NM_025932.2) ENSMUST00000033723.1 ENSMUST00000033723.2 ENSMUST00000033723.3 NM_025932 Q3UI67 Q9D5V6 Q9D870 SYAP1_MOUSE Syap1 uc009uun.1 uc009uun.2 uc009uun.3 uc009uun.4 Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). Interacts (via phosphorylated form and BSD domain) with AKT1; this interaction is enhanced in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation and activates AKT1 (PubMed:23300339). Cytoplasm, perinuclear region Golgi apparatus Perikaryon Cell projection, axon Cell projection, dendrite Cell projection, growth cone Presynaptic cell membrane Postsynaptic cell membrane Membrane Note=Localizes to cholinergic neuromuscular junctions and in actin-rich growth cone regions (PubMed:27344443). Membrane-associated in a epidermal growth factor (EGF)-dependent manner (By similarity). Expressed in the liver, kidney, skeletal muscle and in white and brown adipose tissues (PubMed:23300339, PubMed:27344443). Expressed in the cortex, cerebellum, thalamus, hippocampus, braistem, olfactory bulb, spinal cord and striatum of the brain (PubMed:27344443). Expressed in most neuropil regions containing glutamatergic synaptic terminals (PubMed:27344443). Expressed in the CA1, CA2 and CA3 perikarya of the hippocampus (PubMed:27344443). Expressed in neurons and Purkinje cells (at the protein level) (PubMed:27344443). Up-regulated during adipocyte differentiation (at protein level) (PubMed:23300339). Phosphorylated (PubMed:23300339). Phosphorylation increases in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation (PubMed:23300339). Mice appear normal and healthy (PubMed:27344443). Display no alteration on the survival or axonal elongation in primary embryonic motoneurons (PubMed:27344443). Show no alteration in total AKT phosphorylation in primary embryonic motoneurons (PubMed:27344443). protein binding nucleus nucleoplasm cytoplasm Golgi apparatus cytosol plasma membrane membrane cell junction cell differentiation axon dendrite growth cone extrinsic component of cytoplasmic side of plasma membrane cellular response to insulin stimulus cellular response to platelet-derived growth factor stimulus TORC2 signaling presynaptic membrane cell projection perikaryon synapse postsynaptic membrane positive regulation of fat cell differentiation perinuclear region of cytoplasm cellular response to epidermal growth factor stimulus positive regulation of protein serine/threonine kinase activity positive regulation of protein homodimerization activity cellular response to insulin-like growth factor stimulus uc009uun.1 uc009uun.2 uc009uun.3 uc009uun.4 
ENSMUST00000033725.16 Msl3 ENSMUST00000033725.16 MSL complex subunit 3, transcript variant 13 (from RefSeq NM_001411772.1) B1AUJ7 B1AUJ8 ENSMUST00000033725.1 ENSMUST00000033725.10 ENSMUST00000033725.11 ENSMUST00000033725.12 ENSMUST00000033725.13 ENSMUST00000033725.14 ENSMUST00000033725.15 ENSMUST00000033725.2 ENSMUST00000033725.3 ENSMUST00000033725.4 ENSMUST00000033725.5 ENSMUST00000033725.6 ENSMUST00000033725.7 ENSMUST00000033725.8 ENSMUST00000033725.9 MS3L1_MOUSE Msl31 Msl3l1 NM_001411772 Q9WVG9 uc292rty.1 uc292rty.2 Has a role in chromatin remodeling and transcriptional regulation. Has a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys- 20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. Component of the MSL histone acetyltransferase complex at least composed of the KAT8/MOF, MSL1/hampin, MSL2 and MSL3. Interacts (via the MRG domain) with MSL1 and KAT8/MOF (PubMed:21217699). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WVG9-1; Sequence=Displayed; Name=2; IsoId=Q9WVG9-2; Sequence=VSP_007638, VSP_007639; histone acetyltransferase complex DNA binding nucleus chromatin organization chromatin silencing regulation of transcription, DNA-templated histone acetylation histone deacetylation methylated histone binding NuA4 histone acetyltransferase complex histone H4 acetylation histone H2A acetylation histone H4-K16 acetylation MSL complex uc292rty.1 uc292rty.2 
ENSMUST00000033727.14 Ctps2 ENSMUST00000033727.14 cytidine 5'-triphosphate synthase 2, transcript variant 5 (from RefSeq NR_033143.1) ENSMUST00000033727.1 ENSMUST00000033727.10 ENSMUST00000033727.11 ENSMUST00000033727.12 ENSMUST00000033727.13 ENSMUST00000033727.2 ENSMUST00000033727.3 ENSMUST00000033727.4 ENSMUST00000033727.5 ENSMUST00000033727.6 ENSMUST00000033727.7 ENSMUST00000033727.8 ENSMUST00000033727.9 NR_033143 P70303 PYRG2_MOUSE Q3TPQ2 Q3TT59 uc009uup.1 uc009uup.2 uc009uup.3 uc009uup.4 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). Reaction=ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L- glutamate + phosphate; Xref=Rhea:RHEA:26426, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398, ChEBI:CHEBI:58359, ChEBI:CHEBI:456216; EC=6.3.4.2; Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P70303-1; Sequence=Displayed; Name=2; IsoId=P70303-2; Sequence=VSP_019894; Name=3; IsoId=P70303-3; Sequence=VSP_019893, VSP_019895, VSP_019896; Belongs to the CTP synthase family. nucleotide binding CTP synthase activity ATP binding cytoplasm mitochondrion pyrimidine nucleotide biosynthetic process CTP biosynthetic process glutamine metabolic process ligase activity pyrimidine nucleobase biosynthetic process identical protein binding 'de novo' CTP biosynthetic process cytoophidium uc009uup.1 uc009uup.2 uc009uup.3 uc009uup.4 
ENSMUST00000033730.3 Grpr ENSMUST00000033730.3 gastrin releasing peptide receptor (from RefSeq NM_008177.3) ENSMUST00000033730.1 ENSMUST00000033730.2 GRPR_MOUSE NM_008177 P21729 Q53WV4 uc009uuu.1 uc009uuu.2 uc009uuu.3 uc009uuu.4 This gene encodes a multipass membrane protein that functions as a receptor for gastrin releasing peptide. Signalling through this receptor is important in a variety of physiological processes, including responses to itching, satiety, and fear. [provided by RefSeq, May 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK033473.1, BC113145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849389 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Receptor for gastrin-releasing peptide (GRP) (PubMed:1671171, PubMed:1707129, PubMed:9345264, PubMed:12526815, PubMed:26658875). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation (PubMed:26658875). Contributes to the regulation of food intake (PubMed:12176666). Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain (PubMed:28280205, PubMed:17653196, PubMed:26658875). Contributes primarily to nonhistaminergic itch sensation (PubMed:28280205). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (PubMed:12526815). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (PubMed:34610277). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). P21729; P42866-9: Oprm1; NbExp=4; IntAct=EBI-6049651, EBI-6049667; Cell membrane ulti-pass membrane protein Detected in pancreas and brain (PubMed:1671171, PubMed:9345264). Detected in suprachaismatic nucleus neurons (PubMed:28280205). Detected in neurons in the dorsal horn of the spinal cord (PubMed:17653196). Detected in inhibitory GABAergic interneurons in the lateral nucleus of the amygdala (PubMed:12526815). Detected in approximately 160 neurons of the pre-Botzinger complex (PubMed:26855425). Within the pre-Botzinger complex, there is some overlap with neurons expressing Nmbr with some cells expressing only Grpr or Nmbr while some cells express both (PubMed:26855425). Detected in cells throughout the cortex where it is coexpressed in most of these cells with vasointestinal peptide (VIP) (PubMed:34610277). Mice are born at the expected Mendelian rate, are viable and fertile (PubMed:9345264). They do not decrease their food intake in response to gastrin-releasing peptide (PubMed:12176666). Mice consume more food per meal, but the overall food intake per day remains unchanged (PubMed:12176666). Still, they display increased body weight relative to wild-type (PubMed:12176666). Contrary to wild-type mice, their body temperature remains nearly constant when exposed to cold (4 degrees Celsius) after intracerebroventricular injection of gastrin- releasing peptide (PubMed:9345264). Mutant mice show increased locomotor activity and increased social interactions (PubMed:9345264). They do not show any change in the perception of painful stimuli, but show reduced scratching in response to pruritogenic treatments (PubMed:17653196). Contrary to wild-type, mutant mice do not display imitative scratching after observing spontaneous scratching behavior in another mouse (PubMed:28280205). In one study, mutant mice display normal performance in a water maze, but show decreased inhibition of principal neurons by the interneurons, enhanced long-term potentiation (LTP), and greater and more persistent long-term fear memory (PubMed:12526815). Another study showed that mutants display reduced long-term fear memory (PubMed:34610277). Reduced basal sigh rate (PubMed:26855425). Conditional knockout in the auditory cortex results in diminished auditory fear memories with no significant effect on auditory discrimination (PubMed:34610277). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity bombesin receptor activity protein binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway neuropeptide signaling pathway learning or memory neuropeptide receptor activity G-protein coupled peptide receptor activity membrane integral component of membrane bombesin receptor signaling pathway social behavior psychomotor behavior regulation of cell proliferation neuropeptide binding response to external biotic stimulus motor behavior uc009uuu.1 uc009uuu.2 uc009uuu.3 uc009uuu.4 
ENSMUST00000033731.4 Zfp275 ENSMUST00000033731.4 zinc finger protein 275, transcript variant 1 (from RefSeq NM_031494.2) ENSMUST00000033731.1 ENSMUST00000033731.2 ENSMUST00000033731.3 G3X904 G3X904_MOUSE NM_031494 Zfp275 uc009tlp.1 uc009tlp.2 uc009tlp.3 uc009tlp.4 nucleic acid binding uc009tlp.1 uc009tlp.2 uc009tlp.3 uc009tlp.4 
ENSMUST00000033737.15 Haus7 ENSMUST00000033737.15 HAUS augmin-like complex, subunit 7, transcript variant 1 (from RefSeq NM_028633.3) A2AIF2 ENSMUST00000033737.1 ENSMUST00000033737.10 ENSMUST00000033737.11 ENSMUST00000033737.12 ENSMUST00000033737.13 ENSMUST00000033737.14 ENSMUST00000033737.2 ENSMUST00000033737.3 ENSMUST00000033737.4 ENSMUST00000033737.5 ENSMUST00000033737.6 ENSMUST00000033737.7 ENSMUST00000033737.8 ENSMUST00000033737.9 HAUS7_MOUSE NM_028633 Q8BKT8 Q924Z7 Uchl5ip Uip1 uc009tlu.1 uc009tlu.2 uc009tlu.3 Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly (By similarity). Interacts with UCHL5 (PubMed:11163772). Interacts with EML3 (phosphorylated at 'Thr-882') (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BKT8-1; Sequence=Displayed; Name=2; IsoId=Q8BKT8-2; Sequence=VSP_040922; Belongs to the HAUS7 family. molecular_function cytoplasm centrosome microtubule organizing center spindle cytoskeleton microtubule cell cycle centrosome cycle thioesterase binding microtubule minus-end binding spindle assembly cell division HAUS complex uc009tlu.1 uc009tlu.2 uc009tlu.3 
ENSMUST00000033738.8 Trex2 ENSMUST00000033738.8 three prime repair exonuclease 2 (from RefSeq NM_011907.4) ENSMUST00000033738.1 ENSMUST00000033738.2 ENSMUST00000033738.3 ENSMUST00000033738.4 ENSMUST00000033738.5 ENSMUST00000033738.6 ENSMUST00000033738.7 NM_011907 Q9R1A9 TREX2_MOUSE uc009tlt.1 uc009tlt.2 uc009tlt.3 uc009tlt.4 Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair. Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.2; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 Mg(2+) per subunit. The second magnesium ion interacts with only one residue. Substitution with Mn(2+) results in partial activity. ; Homodimer. Nucleus Belongs to the exonuclease superfamily. TREX family. magnesium ion binding nucleic acid binding nuclease activity exonuclease activity nucleus DNA metabolic process DNA repair cellular response to DNA damage stimulus 3'-5'-exodeoxyribonuclease activity 3'-5' exonuclease activity exodeoxyribonuclease III activity hydrolase activity protein homodimerization activity metal ion binding nucleic acid phosphodiester bond hydrolysis uc009tlt.1 uc009tlt.2 uc009tlt.3 uc009tlt.4 
ENSMUST00000033739.5 Car5b ENSMUST00000033739.5 carbonic anhydrase 5b, mitochondrial (from RefSeq NM_181315.4) CAH5B_MOUSE Ca5b ENSMUST00000033739.1 ENSMUST00000033739.2 ENSMUST00000033739.3 ENSMUST00000033739.4 NM_181315 Q8C3J9 Q8K014 Q9QZA0 uc009uvb.1 uc009uvb.2 uc009uvb.3 uc009uvb.4 Reversible hydration of carbon dioxide. Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Mitochondrion. Belongs to the alpha-carbonic anhydrase family. carbonate dehydratase activity mitochondrion zinc ion binding response to bacterium lyase activity metal ion binding uc009uvb.1 uc009uvb.2 uc009uvb.3 uc009uvb.4 
ENSMUST00000033740.12 Zfp92 ENSMUST00000033740.12 zinc finger protein 92, transcript variant 1 (from RefSeq NM_009566.5) ENSMUST00000033740.1 ENSMUST00000033740.10 ENSMUST00000033740.11 ENSMUST00000033740.2 ENSMUST00000033740.3 ENSMUST00000033740.4 ENSMUST00000033740.5 ENSMUST00000033740.6 ENSMUST00000033740.7 ENSMUST00000033740.8 ENSMUST00000033740.9 NM_009566 Q62396 Q9JJR0 ZFP92_MOUSE uc009tlr.1 uc009tlr.2 uc009tlr.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated biological_process metal ion binding uc009tlr.1 uc009tlr.2 uc009tlr.3 
ENSMUST00000033741.15 Bgn ENSMUST00000033741.15 biglycan, transcript variant 2 (from RefSeq NM_007542.5) Bgn ENSMUST00000033741.1 ENSMUST00000033741.10 ENSMUST00000033741.11 ENSMUST00000033741.12 ENSMUST00000033741.13 ENSMUST00000033741.14 ENSMUST00000033741.2 ENSMUST00000033741.3 ENSMUST00000033741.4 ENSMUST00000033741.5 ENSMUST00000033741.6 ENSMUST00000033741.7 ENSMUST00000033741.8 ENSMUST00000033741.9 NM_007542 Q3TNY9 Q3TNY9_MOUSE uc012hkf.1 uc012hkf.2 uc012hkf.3 uc012hkf.4 This gene encodes a small, leucine-rich repeat proteoglycan that plays important roles in bone mineralization and connective tissue metabolism. The encoded preproprotein undergoes post-translational processing during which chondroitin sulfate or dermatan sulfate chains are attached before incorporation into the extracellular matrix. Mice lacking the encoded protein exhibit reduced growth rate and acquire diminished bone mass progressively with age. [provided by RefSeq, Oct 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK155973.1, L20276.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## May be involved in collagen fiber assembly. Secreted, extracellular space, extracellular matrix Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. blood vessel remodeling cell surface transport vesicle uc012hkf.1 uc012hkf.2 uc012hkf.3 uc012hkf.4 
ENSMUST00000033749.9 Pir ENSMUST00000033749.9 pirin, transcript variant 1 (from RefSeq NM_027153.3) A2AIH9 ENSMUST00000033749.1 ENSMUST00000033749.2 ENSMUST00000033749.3 ENSMUST00000033749.4 ENSMUST00000033749.5 ENSMUST00000033749.6 ENSMUST00000033749.7 ENSMUST00000033749.8 NM_027153 PIR_MOUSE Q3UAN0 Q8CIE9 Q9D711 uc009uvl.1 uc009uvl.2 uc009uvl.3 uc009uvl.4 Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox- state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). Reaction=O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6- dihydroxybenzoate + CO; Xref=Rhea:RHEA:15381, ChEBI:CHEBI:15379, ChEBI:CHEBI:17245, ChEBI:CHEBI:57628, ChEBI:CHEBI:57694; EC=1.13.11.24; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Note=Binds 1 Fe cation per subunit. ; Flavonoid metabolism; quercetin degradation. May interact with NF1/CTF1. Interacts with BCL3. Identified in a complex comprised of PIR, BLC3, NFKB1 and target DNA. Nucleus Cytoplasm Note=Predominantly localized in dot- like subnuclear structures. Weakly expressed in bone marrow. Down-regulated in mice with acute myeloid leukemias induced by either PML-RAR or AML1-ETO fusion oncoproteins. Quercetin is a flavonoid compound synthesized by a variety of plants, including foods for human consumption. Belongs to the pirin family. transcription cofactor activity nucleus cytoplasm cytosol quercetin 2,3-dioxygenase activity oxidoreductase activity myeloid cell differentiation monocyte differentiation metal ion binding dioxygenase activity oxidation-reduction process regulation of nucleic acid-templated transcription uc009uvl.1 uc009uvl.2 uc009uvl.3 uc009uvl.4 
ENSMUST00000033751.8 Vegfd ENSMUST00000033751.8 vascular endothelial growth factor D, transcript variant 1 (from RefSeq NM_010216.3) A2AIH3 ENSMUST00000033751.1 ENSMUST00000033751.2 ENSMUST00000033751.3 ENSMUST00000033751.4 ENSMUST00000033751.5 ENSMUST00000033751.6 ENSMUST00000033751.7 Figf NM_010216 P97946 VEGFD_MOUSE Vegfd uc009uvm.1 uc009uvm.2 uc009uvm.3 uc009uvm.4 This gene encodes a member of the vascular endothelial growth factor (VEGF) family that acts as a ligand for vascular endothelial growth factor receptor 3. Signalling through this protein is important for growth and development of endothelial and vascular tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor. Homodimer; non-covalent and antiparallel. Secreted. Highly expressed in fetal and adult lung. Expressed in a dynamic pattern in several body structures and organs of the embryo such as limb buds, acoustic ganglion, teeth, heart, anterior pituitary as well as lung and kidney mesenchyme, liver, derma, and periosteum of the vertebral column. By the transcription factor c-fos. Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non- covalent interactions (By similarity). Belongs to the PDGF/VEGF growth factor family. angiogenesis response to hypoxia positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation sprouting angiogenesis vascular endothelial growth factor receptor binding protein binding extracellular region extracellular space multicellular organism development growth factor activity cell proliferation positive regulation of cell proliferation response to bacterium membrane cell differentiation regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of interleukin-6 production vascular endothelial growth factor signaling pathway chemoattractant activity protein homodimerization activity vascular endothelial growth factor receptor 3 binding positive regulation of angiogenesis vascular endothelial growth factor receptor signaling pathway positive chemotaxis induction of positive chemotaxis positive regulation of cell division positive regulation of mast cell chemotaxis dopaminergic neuron differentiation vascular endothelial growth factor receptor 2 binding uc009uvm.1 uc009uvm.2 uc009uvm.3 uc009uvm.4 
ENSMUST00000033754.15 Piga ENSMUST00000033754.15 phosphatidylinositol glycan anchor biosynthesis, class A, transcript variant 1 (from RefSeq NM_011081.4) ENSMUST00000033754.1 ENSMUST00000033754.10 ENSMUST00000033754.11 ENSMUST00000033754.12 ENSMUST00000033754.13 ENSMUST00000033754.14 ENSMUST00000033754.2 ENSMUST00000033754.3 ENSMUST00000033754.4 ENSMUST00000033754.5 ENSMUST00000033754.6 ENSMUST00000033754.7 ENSMUST00000033754.8 ENSMUST00000033754.9 NM_011081 PIGA_MOUSE Piga Q64323 Q6LD71 Q8CCQ6 uc009uvo.1 uc009uvo.2 uc009uvo.3 Catalytic subunit of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N- acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol + H(+) + UDP; Xref=Rhea:RHEA:14789, ChEBI:CHEBI:15378, ChEBI:CHEBI:57265, ChEBI:CHEBI:57705, ChEBI:CHEBI:57880, ChEBI:CHEBI:58223; EC=2.4.1.198; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14790; Evidence=; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Component of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP and PIGQ, DPM2. Interacts with PIGC, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity. Interacts directly with PIGY; this interaction regulates glycosylphosphatidylinositol-N-acetylglucosaminyltransferase activity. Interacts with PIGQ. Endoplasmic reticulum membrane; Single-pass membrane protein. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups phosphatidylinositol N-acetylglucosaminyltransferase activity cellular response to leukemia inhibitory factor uc009uvo.1 uc009uvo.2 uc009uvo.3 
ENSMUST00000033756.3 Asb9 ENSMUST00000033756.3 ankyrin repeat and SOCS box-containing 9 (from RefSeq NM_027027.2) ASB9_MOUSE ENSMUST00000033756.1 ENSMUST00000033756.2 NM_027027 Q6GT43 Q91ZT8 Q9DAF7 uc292rrp.1 uc292rrp.2 Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A (By similarity). Protein modification; protein ubiquitination. Mitochondrion The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Belongs to the ankyrin SOCS box (ASB) family. protein binding mitochondrion protein ubiquitination intracellular signal transduction positive regulation of protein catabolic process uc292rrp.1 uc292rrp.2 
ENSMUST00000033761.13 Hcfc1 ENSMUST00000033761.13 host cell factor C1, transcript variant 2 (from RefSeq NM_008224.5) B1AUX1 ENSMUST00000033761.1 ENSMUST00000033761.10 ENSMUST00000033761.11 ENSMUST00000033761.12 ENSMUST00000033761.2 ENSMUST00000033761.3 ENSMUST00000033761.4 ENSMUST00000033761.5 ENSMUST00000033761.6 ENSMUST00000033761.7 ENSMUST00000033761.8 ENSMUST00000033761.9 HCFC1_MOUSE Hcfc1 NM_008224 Q61191 Q684R1 Q7TSB0 Q8C2D0 Q9QWH2 uc009tnm.1 uc009tnm.2 uc009tnm.3 This gene encodes a transcription cofactor that regulates the progression of cell cycle and maintain the ability of embryonic stem cells to self-renew. The encoded protein is a large precursor that undergoes site-specific proteolytic cleavage to yield N- and C-terminal chains that form a non-covalent heterodimer. The encoded protein has been implicated in the regulation of expression of immediate early genes after herpes simplex virus infection and glucose-stimulated secretion of insulin by pancreatic beta cells. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053742.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164142 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Transcriptional coregulator (By similarity). Involved in control of the cell cycle (PubMed:9334261, PubMed:9990006). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (By similarity). Coactivator for EGR2 and GABP2 (By similarity). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys- 4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription respectively) together (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). Recruits KMT2E to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (By similarity). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). Composed predominantly of six polypeptides ranging from 110 to 150 kDa and a minor 300 kDa polypeptide (PubMed:9334261). The majority of N- and C-terminal cleavage products remain tightly, albeit non- covalently, associated (By similarity). Interacts with POU2F1, CREB3, ZBTB17, EGR2, E2F4, CREBZF, SP1, GABP2, Sin3 HDAC complex (SIN3A, HDAC1, HDAC2, SUDS3), SAP30, SIN3B and FHL2 (By similarity). Component of a MLL1 complex, composed of at least the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, DPY30, E2F6, HCFC2, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8, PELP1, PHF20, PRP31, RING2, RUVBL1, RUVBL2, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (By similarity). Interacts directly with THAP3 (via its HBM) (By similarity). Interacts (via the Kelch-repeat domain) with THAP1 (via the HBM); the interaction recruits HCHC1 to the RRM1 (By similarity). Interacts directly with OGT; the interaction, which requires the HCFC1 cleavage site domain, glycosylates and promotes the proteolytic processing of HCFC1 and retains OGT in the nucleus (By similarity). Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L, CXXC1, HCFC1 and DPY30 (By similarity). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (By similarity). Component of a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5; the complex is formed as a result of interactions between components of a nuclear receptor-mediated transcription complex and a histone methylation complex (By similarity). Within the complex interacts with ZNF335 (By similarity). Interacts with TET2 and TET3 (By similarity). Interacts with HCFC1R1 (By similarity). Interacts with THAP11 (PubMed:18585351). Interacts (via Kelch domain) with KMT2E (via HBM motif) (By similarity). Interacts with E2F1 (By similarity). Nucleus Cytoplasm Note=HCFC1R1 modulates its subcellular localization and overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm (By similarity). Localizes to cytoplasm in trigeminal ganglia (PubMed:9990006). Non-processed HCFC1 associates with chromatin. Colocalizes with CREB3 and CANX in the ER. Note=(Microbial infection) In trigeminal ganglia, becoming nuclear upon HSV reactivation from the latent state. Expressed in liver, pituitary gland, skeletal muscle, kidney, eye and brain (at protein level). Also observed at low level in heart, spleen and lung. The HCF repeat is a highly specific proteolytic cleavage signal. The kelch repeats fold into a 6-bladed kelch beta-propeller called the beta-propeller domain which mediates interaction with HCFC1R1. Proteolytically cleaved at one or several PPCE--THET sites within the HCF repeats. Further cleavage of the primary N- and C-terminal chains results in a 'trimming' and accumulation of the smaller chains. Cleavage is promoted by O-glycosylation. O-glycosylated. GlcNAcylation by OGT promotes proteolytic processing. Ubiquitinated. Lys-1817 and Lys-1818 are ubiquitinated both via 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. BAP1 mediated deubiquitination of 'Lys-48'-linked polyubiquitin chains; deubiquitination by BAP1 does not seem to stabilize the protein. Sequence=CAF25305.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter histone acetyltransferase complex RNA polymerase II distal enhancer sequence-specific DNA binding blastocyst hatching chromatin binding transcription coactivator activity protein binding nucleus Ada2/Gcn5/Ada3 transcription activator complex cytoplasm chromatin organization regulation of transcription, DNA-templated cell cycle positive regulation of gene expression release from viral latency axon dendrite protein binding, bridging macromolecular complex activating transcription factor binding identical protein binding neuronal cell body regulation of protein complex assembly histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) positive regulation of transcription, DNA-templated histone acetyltransferase activity (H4-K16 specific) Set1C/COMPASS complex protein stabilization SAGA-type complex MLL1 complex cellular response to organic cyclic compound uc009tnm.1 uc009tnm.2 uc009tnm.3 
ENSMUST00000033763.15 Naa10 ENSMUST00000033763.15 N(alpha)-acetyltransferase 10, NatA catalytic subunit, transcript variant 1 (from RefSeq NM_019870.3) Ard1 Ard1a ENSMUST00000033763.1 ENSMUST00000033763.10 ENSMUST00000033763.11 ENSMUST00000033763.12 ENSMUST00000033763.13 ENSMUST00000033763.14 ENSMUST00000033763.2 ENSMUST00000033763.3 ENSMUST00000033763.4 ENSMUST00000033763.5 ENSMUST00000033763.6 ENSMUST00000033763.7 ENSMUST00000033763.8 ENSMUST00000033763.9 NAA10_MOUSE NM_019870 Q9QY36 Te2 uc009tng.1 uc009tng.2 uc009tng.3 uc009tng.4 Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (PubMed:12888564). Acetylates amino termini that are devoid of initiator methionine (By similarity). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development (By similarity). Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (By similarity). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (By similarity). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (By similarity). Acetylates HIST1H4A (By similarity). Acts as a negative regulator of sister chromatid cohesion during mitosis (By similarity). Reaction=acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetylglycyl-[protein]; Xref=Rhea:RHEA:50496, Rhea:RHEA-COMP:12666, Rhea:RHEA-COMP:12700, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64723, ChEBI:CHEBI:133369; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-alanyl-[protein]; Xref=Rhea:RHEA:50500, Rhea:RHEA-COMP:12701, Rhea:RHEA-COMP:12702, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64718, ChEBI:CHEBI:83683; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-seryl-[protein]; Xref=Rhea:RHEA:50504, Rhea:RHEA-COMP:12703, Rhea:RHEA-COMP:12704, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64738, ChEBI:CHEBI:83690; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-valyl-[protein]; Xref=Rhea:RHEA:50508, Rhea:RHEA-COMP:12705, Rhea:RHEA-COMP:12706, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64741, ChEBI:CHEBI:133371; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:50512, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:12708, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:65250, ChEBI:CHEBI:133372; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-threonyl-[protein]; Xref=Rhea:RHEA:50516, Rhea:RHEA-COMP:12709, Rhea:RHEA-COMP:12710, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64739, ChEBI:CHEBI:133375; EC=2.3.1.255; Evidence=; Component of the N-terminal acetyltransferase A complex (also called the NatA complex) composed of NAA10 and NAA15 (By similarity). Interacts with NAA15 (PubMed:12888564). Component of the N-terminal acetyltransferase A (NatA)/HYPK complex at least composed of NAA10, NAA15 and HYPK, which has N-terminal acetyltransferase activity (By similarity). In complex with NAA15, interacts with HYPK (By similarity). Component of the N-terminal acetyltransferase E (NatE) complex at least composed of NAA10, NAA15 and NAA50 (By similarity). Within the complex interacts with NAA15; the interaction is required for binding to NAAT50 (By similarity). Interacts with NAAT50 (By similarity). The interaction of the NatA complex with NAA50 reduces the acetylation activity of the NatA complex (By similarity). Component of the N-terminal acetyltransferase E (NatE)/HYPK complex at least composed of NAA10, NAA15, NAA50 and HYPK (By similarity). In complex with NAA15, interacts with HYPK; the interaction with HYPK reduces the capacity of the NatA complex to interact with NAA50 (By similarity). Interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during normoxia, an down-regulates it when induced by hypoxia (PubMed:12464182). Interacts with the ribosome (By similarity). Binds to MYLK (By similarity). Interacts with NAA16 (By similarity). Interacts (via its C-terminal domain) with TSC2, leading to its acetylation (By similarity). Interacts with IKBKB (By similarity). Interacts with HSPA1A and HSPA1B leading to its acetylation (By similarity). Cytoplasm Nucleus Note=Also present in the free cytosolic and cytoskeleton-bound polysomes. Ubiquitous. Expressed throughout the developing brain from 11.5 dpc through 17 dpc, continues to be expressed at P0, but then is down-regulated. Cleaved by caspases during apoptosis. Phosphorylation by IKBKB/IKKB at Ser-209 destabilises NAA10 and promotes its proteasome-mediated degradation. Autoacetylated at Lys-136 which stimulates its catalytic activity. Belongs to the acetyltransferase family. ARD1 subfamily. peptide alpha-N-acetyltransferase activity protein binding nucleus nucleolus cytoplasm cytosol protein acetylation N-terminal protein amino acid acetylation N-acetyltransferase activity acetyltransferase activity transferase activity transferase activity, transferring acyl groups N-terminal peptidyl-serine acetylation N-terminal peptidyl-glutamic acid acetylation NatA complex ribosome binding peptide-serine-N-acetyltransferase activity peptide-glutamate-N-acetyltransferase activity negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric uc009tng.1 uc009tng.2 uc009tng.3 uc009tng.4 
ENSMUST00000033765.8 Avpr2 ENSMUST00000033765.8 arginine vasopressin receptor 2, transcript variant 1 (from RefSeq NM_019404.2) AVPR2 Avpr2 ENSMUST00000033765.1 ENSMUST00000033765.2 ENSMUST00000033765.3 ENSMUST00000033765.4 ENSMUST00000033765.5 ENSMUST00000033765.6 ENSMUST00000033765.7 NM_019404 Q3SWS1 Q3SWS1_MOUSE uc009tmy.1 uc009tmy.2 uc009tmy.3 This gene encodes a member of the G-protein coupled receptor 1 family and the vasopressin/oxytocin receptor subfamily. The encoded protein is an arginine vasopressin receptor which, when stimulated, activates the Gs protein/adenylyl cyclase signaling cascade and is involved in water and electrolyte homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. positive regulation of systemic arterial blood pressure G-protein coupled receptor activity vasopressin receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway positive regulation of cell proliferation positive regulation of gene expression membrane integral component of membrane telencephalon development negative regulation of urine volume negative regulation of renal sodium excretion positive regulation of blood pressure uc009tmy.1 uc009tmy.2 uc009tmy.3 
ENSMUST00000033771.11 Opn1mw ENSMUST00000033771.11 opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) (from RefSeq NM_008106.2) ENSMUST00000033771.1 ENSMUST00000033771.10 ENSMUST00000033771.2 ENSMUST00000033771.3 ENSMUST00000033771.4 ENSMUST00000033771.5 ENSMUST00000033771.6 ENSMUST00000033771.7 ENSMUST00000033771.8 ENSMUST00000033771.9 Gcp NM_008106 O35599 OPSG_MOUSE Q548Z4 uc009tnv.1 uc009tnv.2 uc009tnv.3 uc009tnv.4 Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light. Monomer. Homodimer. Homotetramer. Cell membrane ; Multi-pass membrane protein Expressed in retina (at protein level) (PubMed:30948514). Expressed in cone photoreceptor cells (at protein level) (PubMed:11055434). Expressed in the retinal outer nuclear layer and the inner nuclear layer at postnatal day 10. N-glycosylated (PubMed:30948514). O-glycosylated (PubMed:30948514). Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. photoreceptor outer segment G-protein coupled receptor activity protein binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway visual perception phototransduction G-protein coupled photoreceptor activity detection of visible light photoreceptor activity membrane integral component of membrane protein-chromophore linkage positive regulation of cytokinesis identical protein binding response to stimulus cellular response to light stimulus uc009tnv.1 uc009tnv.2 uc009tnv.3 uc009tnv.4 
ENSMUST00000033775.9 Mpp1 ENSMUST00000033775.9 membrane protein, palmitoylated (from RefSeq NM_008621.3) ENSMUST00000033775.1 ENSMUST00000033775.2 ENSMUST00000033775.3 ENSMUST00000033775.4 ENSMUST00000033775.5 ENSMUST00000033775.6 ENSMUST00000033775.7 ENSMUST00000033775.8 Mpp1 NM_008621 Q542P4 Q542P4_MOUSE uc009tpp.1 uc009tpp.2 uc009tpp.3 This gene encodes a protein localized to the cell membrane. The protein serves as a scaffold for the assembly of the actin cytoskeleton, and plays a role in regulating apico-basal cell polarity. [provided by RefSeq, May 2015]. ##Evidence-Data-START## Transcript exon combination :: AK081829.1, BC138314.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity. Cell projection, stereocilium Belongs to the MAGUK family. cytosol nuclear speck uc009tpp.1 uc009tpp.2 uc009tpp.3 
ENSMUST00000033776.15 Dkc1 ENSMUST00000033776.15 dyskeratosis congenita 1, dyskerin, transcript variant 4 (from RefSeq NM_001359413.1) DKC1_MOUSE ENSMUST00000033776.1 ENSMUST00000033776.10 ENSMUST00000033776.11 ENSMUST00000033776.12 ENSMUST00000033776.13 ENSMUST00000033776.14 ENSMUST00000033776.2 ENSMUST00000033776.3 ENSMUST00000033776.4 ENSMUST00000033776.5 ENSMUST00000033776.6 ENSMUST00000033776.7 ENSMUST00000033776.8 ENSMUST00000033776.9 NM_001359413 Q3UWE5 Q9ESX5 uc009tpo.1 uc009tpo.2 uc009tpo.3 uc009tpo.4 Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:12522253, PubMed:15240872). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs (PubMed:12522253, PubMed:15240872). Required for ribosome biogenesis and telomere maintenance (By similarity). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). Reaction=uridine in 5S rRNA = pseudouridine in 5S rRNA; Xref=Rhea:RHEA:47036, Rhea:RHEA-COMP:11730, Rhea:RHEA-COMP:11731, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable core formed by binding of one or two NOP10- DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate. During assembly, the complex contains NAF1 instead of GAR1/NOLA1. The complex also interacts with TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs. Specific interactions with snoRNAs or TERC are mediated by GAR1 and NHP2. Associates with NOLC1/NOPP140. H/ACA snoRNPs interact with the SMN complex, consisting of SMN1 or SMN2, GEMIN2/SIP1, DDX20/GEMIN3, and GEMIN4. This is mediated by interaction between GAR1 and SMN1 or SMN2. The SMN complex may be required for correct assembly of the H/ACA snoRNP complex. Component of the telomerase holoenzyme complex composed of one molecule of TERT, one molecule of WRAP53/TCAB1, two molecules of H/ACA ribonucleoprotein complex subunits DKC1, NOP10, NHP2 and GAR1, and a telomerase RNA template component (TERC). The telomerase holoenzyme complex is associated with TEP1, SMG6/EST1A and POT1. Interacts with SHQ1; this interaction may lead to the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA (By similarity). Interacts with HMBOX1 (By similarity). Interacts with DHX36 (By similarity). Nucleus, nucleolus Nucleus, Cajal body Note=Also localized to Cajal bodies (coiled bodies). Ubiquitously expressed, with elevated levels in Purkinje cells, the olfactory bulb, and Leydig cells of the testis. Expressed throughout development, particularly in developing epithelial tissues. Belongs to the pseudouridine synthase TruB family. snoRNA guided rRNA pseudouridine synthesis enzyme-directed rRNA pseudouridine synthesis box H/ACA snoRNA 3'-end processing pseudouridine synthesis fibrillar center telomerase activity RNA binding protein binding nucleus nucleoplasm telomerase holoenzyme complex nucleolus rRNA processing RNA processing telomere maintenance via telomerase positive regulation of cell proliferation RNA modification pseudouridine synthase activity Cajal body isomerase activity rRNA pseudouridine synthesis snRNA pseudouridine synthesis box H/ACA snoRNP complex positive regulation of telomere maintenance via telomerase box H/ACA snoRNA metabolic process box H/ACA snoRNA binding ribosome biogenesis positive regulation of telomerase activity telomerase RNA binding box H/ACA telomerase RNP complex scaRNA localization to Cajal body telomerase RNA stabilization positive regulation of establishment of protein localization to telomere regulation of telomerase RNA localization to Cajal body positive regulation of telomerase RNA localization to Cajal body mRNA pseudouridine synthesis uc009tpo.1 uc009tpo.2 uc009tpo.3 uc009tpo.4 
ENSMUST00000033783.2 Tceal6 ENSMUST00000033783.2 transcription elongation factor A (SII)-like 6 (from RefSeq NM_025355.4) ENSMUST00000033783.1 NM_025355 Q9DB24 Q9DB24_MOUSE Tceal6 uc009uhc.1 uc009uhc.2 uc009uhc.3 uc009uhc.4 translation elongation factor activity nucleus translational elongation WW domain binding uc009uhc.1 uc009uhc.2 uc009uhc.3 uc009uhc.4 
ENSMUST00000033800.13 Plp1 ENSMUST00000033800.13 proteolipid protein (myelin) 1, transcript variant 1 (from RefSeq NM_011123.4) ENSMUST00000033800.1 ENSMUST00000033800.10 ENSMUST00000033800.11 ENSMUST00000033800.12 ENSMUST00000033800.2 ENSMUST00000033800.3 ENSMUST00000033800.4 ENSMUST00000033800.5 ENSMUST00000033800.6 ENSMUST00000033800.7 ENSMUST00000033800.8 ENSMUST00000033800.9 NM_011123 Plp1 Q3UYM8 Q3UYM8_MOUSE uc009ujc.1 uc009ujc.2 uc009ujc.3 uc009ujc.4 This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Myelin membrane Belongs to the myelin proteolipid protein family. structural molecule activity plasma membrane integrin-mediated signaling pathway axon ensheathment glial cell differentiation membrane integral component of membrane structural constituent of myelin sheath myelination myelin sheath uc009ujc.1 uc009ujc.2 uc009ujc.3 uc009ujc.4 
ENSMUST00000033804.5 Zcchc18 ENSMUST00000033804.5 zinc finger, CCHC domain containing 18, transcript variant 1 (from RefSeq NM_001035510.2) ENSMUST00000033804.1 ENSMUST00000033804.2 ENSMUST00000033804.3 ENSMUST00000033804.4 NM_001035510 Q8VD24 Q9DB17 Sizn2 ZCC18_MOUSE Zcchc18 uc009ujm.1 uc009ujm.2 uc009ujm.3 Belongs to the ZCCHC12 family. nuclear speck ligand-dependent nuclear receptor transcription coactivator activity BMP signaling pathway metal ion binding positive regulation of nucleic acid-templated transcription uc009ujm.1 uc009ujm.2 uc009ujm.3 
ENSMUST00000033805.15 Psmd10 ENSMUST00000033805.15 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10, transcript variant 1 (from RefSeq NM_016883.4) ENSMUST00000033805.1 ENSMUST00000033805.10 ENSMUST00000033805.11 ENSMUST00000033805.12 ENSMUST00000033805.13 ENSMUST00000033805.14 ENSMUST00000033805.2 ENSMUST00000033805.3 ENSMUST00000033805.4 ENSMUST00000033805.5 ENSMUST00000033805.6 ENSMUST00000033805.7 ENSMUST00000033805.8 ENSMUST00000033805.9 NM_016883 PSD10_MOUSE Q8R0G2 Q9D383 Q9D7N8 Q9Z2X2 uc009ulj.1 uc009ulj.2 uc009ulj.3 uc009ulj.4 Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module (By similarity). Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export (By similarity). Part of transient complex containing PSMD10, PSMC4, PSMC5 and PAAF1 formed during the assembly of the 26S proteasome. Stays associated throughout the assembly of the PA700/19S RC and is released upon association with the 20S core. Interacts with PSMC4. Interacts with RB1. Interacts with CDK4. Interacts with MDM2. Interacts with RELA. Associates with a CDK4:CCND2 serine/threonine kinase complex (By similarity). Interacts with ARHGDIA and increases the interaction between ARHGDIA and RHOA, hence promotes ARHGDIA inactivation of RHOA and ROCK (By similarity). Q9Z2X2; P43686: PSMC4; Xeno; NbExp=4; IntAct=EBI-8377084, EBI-743997; Q9Z2X2; P06400: RB1; Xeno; NbExp=3; IntAct=EBI-8377084, EBI-491274; Cytoplasm Nucleus Up-regulated by activated HRAS. Sequence=BAB31128.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter proteasome complex protein binding nucleus cytoplasm cytosol regulation of transcription from RNA polymerase II promoter apoptotic process cytoplasmic sequestering of NF-kappaB transcription factor binding proteasome regulatory particle, base subcomplex positive regulation of cell growth positive regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of apoptotic process negative regulation of MAPK cascade negative regulation of DNA damage response, signal transduction by p53 class mediator intermediate filament cytoskeleton positive regulation of cyclin-dependent protein serine/threonine kinase activity RNA polymerase II sequence-specific DNA binding transcription factor binding proteasome regulatory particle assembly negative regulation of release of cytochrome c from mitochondria uc009ulj.1 uc009ulj.2 uc009ulj.3 uc009ulj.4 
ENSMUST00000033806.5 Vsig1 ENSMUST00000033806.5 V-set and immunoglobulin domain containing 1, transcript variant 1 (from RefSeq NM_030181.3) A0A0B4J1E9 A0A0B4J1E9_MOUSE ENSMUST00000033806.1 ENSMUST00000033806.2 ENSMUST00000033806.3 ENSMUST00000033806.4 NM_030181 Vsig1 uc009ulh.1 uc009ulh.2 uc009ulh.3 Membrane ; Single- pass type I membrane protein epithelial cell morphogenesis plasma membrane membrane integral component of membrane maintenance of gastrointestinal epithelium uc009ulh.1 uc009ulh.2 uc009ulh.3 
ENSMUST00000033809.4 Prps1 ENSMUST00000033809.4 phosphoribosyl pyrophosphate synthetase 1 (from RefSeq NM_021463.4) ENSMUST00000033809.1 ENSMUST00000033809.2 ENSMUST00000033809.3 NM_021463 PRPS1_MOUSE Q76MX9 Q9D7G0 uc009uky.1 uc009uky.2 uc009uky.3 uc009uky.4 Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Reaction=ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1- diphosphate + AMP + H(+); Xref=Rhea:RHEA:15609, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58017, ChEBI:CHEBI:78346, ChEBI:CHEBI:456215; EC=2.7.6.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by magnesium and inorganic phosphate. Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity). Expressed in both vestibular and cochlea hair cells in early developing and postnatal mice and can also be detected in the spiral ganglion cells in at post natal day 6. Belongs to the ribose-phosphate pyrophosphokinase family. nucleotide binding magnesium ion binding ribose phosphate diphosphokinase complex ribose phosphate diphosphokinase activity ATP binding cytoplasm 5-phosphoribose 1-diphosphate biosynthetic process purine nucleobase metabolic process purine nucleotide biosynthetic process AMP biosynthetic process nervous system development nucleoside metabolic process ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process AMP binding kinase activity phosphorylation transferase activity GDP binding ribose phosphate metabolic process carbohydrate binding macromolecular complex urate biosynthetic process identical protein binding protein homodimerization activity ADP binding cellular biosynthetic process hypoxanthine biosynthetic process metal ion binding uc009uky.1 uc009uky.2 uc009uky.3 uc009uky.4 
ENSMUST00000033818.10 Atp11a ENSMUST00000033818.10 ATPase, class VI, type 11A, transcript variant 2 (from RefSeq NM_001293667.1) Atp11a E9Q3G7 E9Q3G7_MOUSE ENSMUST00000033818.1 ENSMUST00000033818.2 ENSMUST00000033818.3 ENSMUST00000033818.4 ENSMUST00000033818.5 ENSMUST00000033818.6 ENSMUST00000033818.7 ENSMUST00000033818.8 ENSMUST00000033818.9 NM_001293667 uc009kwh.1 uc009kwh.2 uc009kwh.3 Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Membrane ulti-pass membrane protein Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. nucleotide binding magnesium ion binding ATP binding phospholipid transport membrane integral component of membrane uc009kwh.1 uc009kwh.2 uc009kwh.3 
ENSMUST00000033820.4 F7 ENSMUST00000033820.4 coagulation factor VII (from RefSeq NM_010172.5) ENSMUST00000033820.1 ENSMUST00000033820.2 ENSMUST00000033820.3 F7 NM_010172 Q542C2 Q542C2_MOUSE uc009kwr.1 uc009kwr.2 uc009kwr.3 uc009kwr.4 uc009kwr.5 This gene encodes a vitamin K-dependent serine protease that plays a critical role in the extrinsic pathway of blood coagulation. Upon contact with tissue factor III (TF III), the encoded protein forms an activated complex termed TF-FVIIa that initiates the coagulation cascade involving other coagulation factors, ultimately resulting in a fibrin clot. Complete lack of the encoded protein in mice results in in perinatal lethality due to bleeding from normal blood vessels. [provided by RefSeq, Apr 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061149.1, AK171362.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. Reaction=Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.; EC=3.4.21.21; Evidence=; Heterodimer of a light chain and a heavy chain linked by a disulfide bond. Secreted Lacks conserved residue(s) required for the propagation of feature annotation. response to hypoxia positive regulation of leukocyte chemotaxis endopeptidase activity serine-type endopeptidase activity receptor binding calcium ion binding extracellular region extracellular space proteolysis blood coagulation circadian rhythm peptidase activity serine-type peptidase activity response to hormone response to carbon dioxide positive regulation of platelet-derived growth factor receptor signaling pathway response to organic cyclic compound protein processing hydrolase activity positive regulation of blood coagulation animal organ regeneration response to nutrient levels vesicle response to estradiol response to vitamin K response to genistein response to estrogen positive regulation of positive chemotaxis positive regulation of protein kinase B signaling response to growth hormone response to anticoagulant response to cholesterol response to thyroid hormone response to thyroxine response to Thyroid stimulating hormone response to 2,3,7,8-tetrachlorodibenzodioxine response to astaxanthin response to thyrotropin-releasing hormone serine-type peptidase complex uc009kwr.1 uc009kwr.2 uc009kwr.3 uc009kwr.4 uc009kwr.5 
ENSMUST00000033822.4 Proz ENSMUST00000033822.4 protein Z, vitamin K-dependent plasma glycoprotein, transcript variant 1 (from RefSeq NM_025834.4) ENSMUST00000033822.1 ENSMUST00000033822.2 ENSMUST00000033822.3 NM_025834 PROZ_MOUSE Q9CQW3 uc009kwu.1 uc009kwu.2 uc009kwu.3 Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Secreted. Plasma. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Belongs to the peptidase S1 family. Although homologous with the vitamin K-dependent clotting factors, it has lost two of the essential catalytic residues and has no enzymatic activity. serine-type endopeptidase activity calcium ion binding extracellular region extracellular space proteolysis blood coagulation hemostasis uc009kwu.1 uc009kwu.2 uc009kwu.3 
ENSMUST00000033824.8 Lamp1 ENSMUST00000033824.8 lysosomal-associated membrane protein 1, transcript variant 2 (from RefSeq NM_010684.3) ENSMUST00000033824.1 ENSMUST00000033824.2 ENSMUST00000033824.3 ENSMUST00000033824.4 ENSMUST00000033824.5 ENSMUST00000033824.6 ENSMUST00000033824.7 Lamp1 NM_010684 Q3TA96 Q3TA96_MOUSE uc009kxa.1 uc009kxa.2 uc009kxa.3 Cell membrane ; Single-pass type I membrane protein Endosome membrane ; Single-pass type I membrane protein Lysosome membrane ; Single-pass type I membrane protein mbrane ; Single-pass type I membrane protein Belongs to the LAMP family. Lacks conserved residue(s) required for the propagation of feature annotation. cytoplasm lysosome lysosomal membrane late endosome multivesicular body vacuole cytosol plasma membrane granzyme-mediated apoptotic signaling pathway membrane integral component of membrane enzyme binding integral component of synaptic vesicle membrane dendrite cytoplasmic vesicle neuronal cell body positive regulation of natural killer cell degranulation positive regulation of natural killer cell mediated cytotoxicity autophagic cell death perinuclear region of cytoplasm establishment of protein localization to organelle Golgi to lysosome transport alveolar lamellar body regulation of organelle transport along microtubule uc009kxa.1 uc009kxa.2 uc009kxa.3 
ENSMUST00000033825.11 Adprhl1 ENSMUST00000033825.11 ADP-ribosylhydrolase like 1, transcript variant 1 (from RefSeq NM_172750.5) ARHL1_MOUSE Arh2 ENSMUST00000033825.1 ENSMUST00000033825.10 ENSMUST00000033825.2 ENSMUST00000033825.3 ENSMUST00000033825.4 ENSMUST00000033825.5 ENSMUST00000033825.6 ENSMUST00000033825.7 ENSMUST00000033825.8 ENSMUST00000033825.9 NM_172750 Q8BGK2 Q8C4L0 uc009kxf.1 uc009kxf.2 uc009kxf.3 Required for myofibril assembly and outgrowth of the cardiac chambers in the developing heart (By similarity). Appears to be catalytically inactive, showing no activity against O-acetyl-ADP-ribose (PubMed:17075046). Cytoplasm, myofibril, sarcomere Expressed in the embryonic heart at E11.5. Belongs to the ADP-ribosylglycohydrolase family. Although it belongs to the ADP-ribosylglycohydrolase family, lacks the metal-binding and substrate-binding residues, suggesting that it has no hydrolase activity. Sequence=BAC38332.1; Type=Erroneous initiation; Evidence=; magnesium ion binding ADP-ribosylarginine hydrolase activity GTPase activator activity cell cellular protein modification process intracellular protein transport hydrolase activity Rab GTPase binding protein de-ADP-ribosylation activation of GTPase activity uc009kxf.1 uc009kxf.2 uc009kxf.3 
ENSMUST00000033826.4 Atp4b ENSMUST00000033826.4 ATPase, H+/K+ exchanging, beta polypeptide (from RefSeq NM_009724.2) Atp4b ENSMUST00000033826.1 ENSMUST00000033826.2 ENSMUST00000033826.3 NM_009724 Q0VBB6 Q0VBB6_MOUSE uc009kxu.1 uc009kxu.2 uc009kxu.3 This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Membrane ; Single- pass type II membrane protein Belongs to the X(+)/potassium ATPases subunit beta family. sodium:potassium-exchanging ATPase complex ion transport potassium ion transport sodium ion transport response to organonitrogen compound membrane integral component of membrane response to lipopolysaccharide uc009kxu.1 uc009kxu.2 uc009kxu.3 
ENSMUST00000033828.7 Gas6 ENSMUST00000033828.7 growth arrest specific 6 (from RefSeq NM_019521.2) ENSMUST00000033828.1 ENSMUST00000033828.2 ENSMUST00000033828.3 ENSMUST00000033828.4 ENSMUST00000033828.5 ENSMUST00000033828.6 GAS6_MOUSE NM_019521 Q61592 Q99K57 uc009kya.1 uc009kya.2 uc009kya.3 Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Heterodimer and heterotetramer with AXL. Secreted Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. GAS6 deficient mice show protection against thrombosis, but no spontaneous bleeding. neuron migration phosphatidylserine binding positive regulation of protein phosphorylation positive regulation of cytokine-mediated signaling pathway positive regulation of glomerular filtration receptor binding voltage-gated calcium channel activity calcium ion binding extracellular region extracellular space cytoplasm protein phosphorylation phagocytosis apoptotic process signal transduction enzyme linked receptor protein signaling pathway blood coagulation cellular response to starvation positive regulation of gene expression negative regulation of tumor necrosis factor-mediated signaling pathway macrophage cytokine production peptidyl-serine phosphorylation fusion of virus membrane with host plasma membrane viral genome replication protein tyrosine kinase activator activity protein binding, bridging receptor tyrosine kinase binding animal organ regeneration cell-substrate adhesion positive regulation of TOR signaling activation of protein kinase B activity negative regulation of interferon-gamma production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of natural killer cell differentiation positive regulation of peptidyl-serine phosphorylation cellular response to interferon-alpha cellular response to drug B cell chemotaxis regulation of growth cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process apoptotic cell clearance negative regulation of sequence-specific DNA binding transcription factor activity protein kinase B signaling positive regulation of protein kinase activity negative regulation of transcription, DNA-templated viral entry into host cell receptor-mediated virion attachment to host cell positive regulation of protein export from nucleus metal ion binding receptor agonist activity positive regulation of fibroblast proliferation negative regulation of interleukin-1 secretion positive regulation of phagocytosis positive regulation of protein kinase B signaling positive regulation of protein tyrosine kinase activity negative regulation of biomineral tissue development positive regulation of ERK1 and ERK2 cascade calcium ion transmembrane transport cellular response to vitamin K cellular response to glucose stimulus cellular response to growth factor stimulus protein localization to plasma membrane extracellular matrix assembly dendritic cell differentiation hematopoietic stem cell migration to bone marrow negative regulation of oligodendrocyte apoptotic process negative regulation of interleukin-6 secretion negative regulation of fibroblast apoptotic process negative regulation of endothelial cell apoptotic process positive regulation of dendritic cell chemotaxis negative regulation of renal albumin absorption negative regulation of dendritic cell apoptotic process uc009kya.1 uc009kya.2 uc009kya.3 
ENSMUST00000033839.9 Coprs ENSMUST00000033839.9 coordinator of PRMT5, differentiation stimulator, transcript variant 1 (from RefSeq NM_025556.3) COPRS_MOUSE Copr5 ENSMUST00000033839.1 ENSMUST00000033839.2 ENSMUST00000033839.3 ENSMUST00000033839.4 ENSMUST00000033839.5 ENSMUST00000033839.6 ENSMUST00000033839.7 ENSMUST00000033839.8 NM_025556 Q9CQ13 uc009kyr.1 uc009kyr.2 uc009kyr.3 uc009kyr.4 Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression (By similarity). Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation. Interacts with PRMT5. Interacts with histone H4; specifically interacts with the N-terminus of histone H4 but not with histone H3 (By similarity). Interacts with CBFB. Found in a complex with PRMT5, RUNX1 and CBFB. Nucleus blastocyst hatching protein binding nucleus cytosol plasma membrane chromatin organization muscle organ development histone binding histone H4-R3 methylation uc009kyr.1 uc009kyr.2 uc009kyr.3 uc009kyr.4 
ENSMUST00000033842.4 Myom2 ENSMUST00000033842.4 myomesin 2, transcript variant 1 (from RefSeq NM_008664.3) ENSMUST00000033842.1 ENSMUST00000033842.2 ENSMUST00000033842.3 Myom2 NM_008664 Q14BI5 Q14BI5_MOUSE uc009kzm.1 uc009kzm.2 uc009kzm.3 uc009kzm.4 extraocular skeletal muscle development structural constituent of cytoskeleton cytoskeleton striated muscle thin filament muscle contraction structural constituent of muscle kinase binding sarcomere Z disc skeletal muscle thin filament assembly skeletal muscle myosin thick filament assembly M band sarcomere organization cardiac muscle fiber development actin filament binding muscle alpha-actinin binding cardiac myofibril assembly cardiac muscle tissue morphogenesis striated muscle myosin thick filament assembly uc009kzm.1 uc009kzm.2 uc009kzm.3 uc009kzm.4 
ENSMUST00000033846.7 Angpt2 ENSMUST00000033846.7 angiopoietin 2 (from RefSeq NM_007426.4) ANGP2_MOUSE Agpt2 ENSMUST00000033846.1 ENSMUST00000033846.2 ENSMUST00000033846.3 ENSMUST00000033846.4 ENSMUST00000033846.5 ENSMUST00000033846.6 NM_007426 O35608 Q3U1A1 Q9D2D2 uc009kzu.1 uc009kzu.2 uc009kzu.3 This gene encodes an endothelial cell (EC)-derived regulator of angiogenesis and ligand for endothelial-specific receptor tyrosine kinase. The encoded protein acts as an anti-apoptotic factor for stressed ECs and a proapoptotic factor for resting ECs. [provided by RefSeq, Jan 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK143974.1, AK019860.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (By similarity). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (By similarity). In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression (By similarity). In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). Involved in the regulation of lymphangiogenesis (PubMed:28179430, PubMed:32908006). Interacts with TEK/TIE2, competing for the same binding site as ANGPT1 (By similarity). Interacts with ITGA5 (By similarity). Interacts with SVEP1/polydom (PubMed:28179430). Secreted Expressed in the ovary, uterus and placenta. The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor. angiogenesis response to hypoxia blood vessel remodeling vascular endothelial growth factor receptor binding protein binding extracellular region extracellular space nucleus plasma membrane transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development germ cell development endoderm development response to radiation response to mechanical stimulus response to glucose negative regulation of cell-substrate adhesion response to organic cyclic compound response to activity negative regulation of angiogenesis hemopoiesis cell differentiation receptor tyrosine kinase binding animal organ regeneration cell projection negative regulation of blood vessel endothelial cell migration regulation of angiogenesis positive regulation of angiogenesis metal ion binding Tie signaling pathway blood vessel morphogenesis negative regulation of positive chemotaxis maternal process involved in female pregnancy cellular response to growth factor stimulus glomerulus vasculature development uc009kzu.1 uc009kzu.2 uc009kzu.3 
ENSMUST00000033852.8 Defb3 ENSMUST00000033852.8 defensin beta 3 (from RefSeq NM_013756.2) Bd3 DEFB3_MOUSE ENSMUST00000033852.1 ENSMUST00000033852.2 ENSMUST00000033852.3 ENSMUST00000033852.4 ENSMUST00000033852.5 ENSMUST00000033852.6 ENSMUST00000033852.7 NM_013756 Q29R78 Q9WTL0 uc009lao.1 uc009lao.2 uc009lao.3 Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa. Secreted. Highest expression in salivary glands, epididymis, ovary and pancreas and to a lesser extent in lung, liver and brain. Low or no expression in skeletal muscle and tongue. By bacterial infection. Belongs to the beta-defensin family. LAP/TAP subfamily. extracellular region extracellular space chemotaxis defense response CCR6 chemokine receptor binding chemoattractant activity defense response to bacterium positive chemotaxis cell chemotaxis uc009lao.1 uc009lao.2 uc009lao.3 
ENSMUST00000033854.4 Defb8 ENSMUST00000033854.4 defensin beta 8 (from RefSeq NM_153108.4) A0A0R4J0D9 A0A0R4J0D9_MOUSE Defb8 ENSMUST00000033854.1 ENSMUST00000033854.2 ENSMUST00000033854.3 NM_153108 uc009laq.1 uc009laq.2 uc009laq.3 Secreted extracellular region defense response uc009laq.1 uc009laq.2 uc009laq.3 
ENSMUST00000033865.16 Nek3 ENSMUST00000033865.16 NIMA (never in mitosis gene a)-related expressed kinase 3, transcript variant 2 (from RefSeq NM_011848.5) ENSMUST00000033865.1 ENSMUST00000033865.10 ENSMUST00000033865.11 ENSMUST00000033865.12 ENSMUST00000033865.13 ENSMUST00000033865.14 ENSMUST00000033865.15 ENSMUST00000033865.2 ENSMUST00000033865.3 ENSMUST00000033865.4 ENSMUST00000033865.5 ENSMUST00000033865.6 ENSMUST00000033865.7 ENSMUST00000033865.8 ENSMUST00000033865.9 F8WGD4 F8WGD4_MOUSE NM_011848 Nek3 uc009lcr.1 uc009lcr.2 uc009lcr.3 uc009lcr.4 protein kinase activity ATP binding protein phosphorylation uc009lcr.1 uc009lcr.2 uc009lcr.3 uc009lcr.4 
ENSMUST00000033866.9 Vps36 ENSMUST00000033866.9 vacuolar protein sorting 36, transcript variant 1 (from RefSeq NM_027338.2) ENSMUST00000033866.1 ENSMUST00000033866.2 ENSMUST00000033866.3 ENSMUST00000033866.4 ENSMUST00000033866.5 ENSMUST00000033866.6 ENSMUST00000033866.7 ENSMUST00000033866.8 NM_027338 Q91XD6 Q9CVA3 VPS36_MOUSE uc009lct.1 uc009lct.2 uc009lct.3 Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS36 and two copies of VPS25 (By similarity). Interacts with VPS25, SNF8, TSG101 and CHMP6 (By similarity). Interacts (via GLUE domain) with ubiquitin (PubMed:15755741). Interacts with RILPL1 (via the C- terminal domain); which recruits ESCRT-II to the endosome membranes (By similarity). Interacts with ECPAS (By similarity). Q91XD6; P62990: UBC; Xeno; NbExp=2; IntAct=EBI-8318017, EBI-413053; Cytoplasm Endosome Late endosome Membrane Nucleus Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation. The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates binding to ubiquitin and phosphoinosides. Belongs to the VPS36 family. ESCRT II complex nucleus cytoplasm lysosome endosome late endosome cytosol protein C-terminus binding lipid binding protein transport membrane endosomal transport late endosome membrane phosphatidylinositol-3-phosphate binding endosome transport via multivesicular body sorting pathway ubiquitin binding protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway uc009lct.1 uc009lct.2 uc009lct.3 
ENSMUST00000033871.8 Slc25a15 ENSMUST00000033871.8 solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15, transcript variant 1 (from RefSeq NM_181325.4) ENSMUST00000033871.1 ENSMUST00000033871.2 ENSMUST00000033871.3 ENSMUST00000033871.4 ENSMUST00000033871.5 ENSMUST00000033871.6 ENSMUST00000033871.7 NM_181325 ORNT1_MOUSE Ornt1 Q9WVD5 Slc25a15 uc009lcz.1 uc009lcz.2 uc009lcz.3 uc009lcz.4 Mitochondrial ornithine-citrulline antiporter. Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle. Lysine and arginine are also transported by the antiport mechanism (By similarity). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane (By similarity). Reaction=H(+)(in) + L-citrulline(in) + L-ornithine(out) = H(+)(out) + L-citrulline(out) + L-ornithine(in); Xref=Rhea:RHEA:70787, ChEBI:CHEBI:15378, ChEBI:CHEBI:46911, ChEBI:CHEBI:57743; Evidence=; Reaction=L-arginine(out) + L-ornithine(in) = L-arginine(in) + L- ornithine(out); Xref=Rhea:RHEA:34991, ChEBI:CHEBI:32682, ChEBI:CHEBI:46911; Evidence=; Reaction=L-lysine(in) + L-ornithine(out) = L-lysine(out) + L- ornithine(in); Xref=Rhea:RHEA:70799, ChEBI:CHEBI:32551, ChEBI:CHEBI:46911; Evidence=; Reaction=H(+)(in) + L-lysine(out) = H(+)(out) + L-lysine(in); Xref=Rhea:RHEA:70795, ChEBI:CHEBI:15378, ChEBI:CHEBI:32551; Evidence=; Reaction=H(+)(in) + L-ornithine(out) = H(+)(out) + L-ornithine(in); Xref=Rhea:RHEA:70791, ChEBI:CHEBI:15378, ChEBI:CHEBI:46911; Evidence=; Inhibited by pyridoxal 5'-phosphate as well as by mercurials (mersalyl, p-chloromercuribenzene sulfonate, and mercuric chloride), N-ethylmaleimide and spermine. Mitochondrion inner membrane ; Multi-pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Widely expressed, with highest levels in the liver, testis and kidney. In the brain, expressed at high levels in the hypothalamus. Belongs to the mitochondrial carrier (TC 2.A.29) family. L-ornithine transmembrane transporter activity mitochondrion mitochondrial inner membrane membrane integral component of membrane mitochondrial L-ornithine transmembrane transport uc009lcz.1 uc009lcz.2 uc009lcz.3 uc009lcz.4 
ENSMUST00000033873.9 Erlin2 ENSMUST00000033873.9 ER lipid raft associated 2, transcript variant 1 (from RefSeq NM_153592.3) ENSMUST00000033873.1 ENSMUST00000033873.2 ENSMUST00000033873.3 ENSMUST00000033873.4 ENSMUST00000033873.5 ENSMUST00000033873.6 ENSMUST00000033873.7 ENSMUST00000033873.8 ERLN2_MOUSE NM_153592 Q8BFZ9 Q8BML8 Spfh2 uc009lhr.1 uc009lhr.2 uc009lhr.3 uc009lhr.4 uc009lhr.5 Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol- accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity). Forms a heteromeric complex with ERLIN1 (By similarity). In complex with ERLIN1, interacts with RNF170 (PubMed:21610068). Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination (PubMed:17502376). Interacts with SCAP, INSIG1, SREBF1 and SREBF2 under cholesterol sufficiency conditions; indicative for an association with the SCAP-SREBP-INSIG complex (By similarity). Probably part of an AMFR/gp78 and INSIG1-containing ubiquitin ligase complex involved in ERAD of HMGCR (By similarity). Interacts with TMUB1; TMUB1 bridges the association with AMFR (By similarity). Interacts with SYVN1 and RNF139 (By similarity). Interacts with TMEM259 (PubMed:25977983). Interacts with TMEM41B (By similarity). Endoplasmic reticulum membrane ; Single-pass type II membrane protein Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. Belongs to the band 7/mec-2 family. protein binding endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane lipid metabolic process steroid metabolic process cholesterol metabolic process cholesterol binding membrane integral component of membrane ER-associated ubiquitin-dependent protein catabolic process ubiquitin protein ligase binding SREBP signaling pathway macromolecular complex membrane raft negative regulation of cholesterol biosynthetic process negative regulation of fatty acid biosynthetic process uc009lhr.1 uc009lhr.2 uc009lhr.3 uc009lhr.4 uc009lhr.5 
ENSMUST00000033875.10 Plpbp ENSMUST00000033875.10 pyridoxal phosphate binding protein, transcript variant 1 (from RefSeq NM_054057.4) ENSMUST00000033875.1 ENSMUST00000033875.2 ENSMUST00000033875.3 ENSMUST00000033875.4 ENSMUST00000033875.5 ENSMUST00000033875.6 ENSMUST00000033875.7 ENSMUST00000033875.8 ENSMUST00000033875.9 NM_054057 PLPHP_MOUSE Plpbp Prosc Q9Z2Y8 uc009lhw.1 uc009lhw.2 Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. mitochondrion pyridoxal phosphate binding uc009lhw.1 uc009lhw.2 
ENSMUST00000033876.14 Adgra2 ENSMUST00000033876.14 adhesion G protein-coupled receptor A2 (from RefSeq NM_054044.2) AGRA2_MOUSE Adgra2 B2RRK0 ENSMUST00000033876.1 ENSMUST00000033876.10 ENSMUST00000033876.11 ENSMUST00000033876.12 ENSMUST00000033876.13 ENSMUST00000033876.2 ENSMUST00000033876.3 ENSMUST00000033876.4 ENSMUST00000033876.5 ENSMUST00000033876.6 ENSMUST00000033876.7 ENSMUST00000033876.8 ENSMUST00000033876.9 Gpr124 NM_054044 Q91ZV8 Tem5 uc009lhx.1 uc009lhx.2 uc009lhx.3 uc009lhx.4 Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:25373781, PubMed:25558062, PubMed:28803732). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (PubMed:21071672, PubMed:21282641, PubMed:21421844, PubMed:25373781, PubMed:28288111). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher- order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (By similarity). ADGRA2- tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (By similarity). Interacts with RECK; the interaction is direct (PubMed:28803732). Interacts (via PDZ-binding motif) with DLG1 (via PDZ domains) (PubMed:25558062). The cleaved extracellular subunit interacts with the integrin heterodimer ITGAV:ITGB3 (By similarity). Cell membrane ulti-pass membrane protein Cell projection, filopodium Note=Enriched at lateral cell borders and also at sites of cell-ECM (extracellular matrix) contact. Abundantly expressed in the vasculature of the developing embryo (PubMed:11559528, PubMed:21071672, PubMed:21282641). Expression in normal adult tissues is specifically vascular with endothelial expression in CNS, including brain and retina and more widespread pericyte expression in the brain and organs, including the kidney, pancreas and corpus luteum (PubMed:21071672). At 10 dpc expressed in a wide variety of tissues with relatively more abundant expression in limb buds (PubMed:18848646). At 10.5-12.5 dpc, detected in vessels of the developing CNS and perineural vascular plexus (PNVP) (PubMed:21282641). Expressed in both endothelial cells and pericytes, most prominently in brain and neural tube, and to a lesser degrees in non-CNS embryonic organs, including the liver, heart, and kidney (PubMed:18848646, PubMed:21282641). Expressed also in embryonic epithelium of lung and esophagus and in mesenchyme (PubMed:18848646, PubMed:21282641). Detected in mesenchyme of the palatal shelf at 12.5 dpc (PubMed:21282641). Up-regulated by the growth factors activin AB (INHBA: INHBB dimer) and TGFB1 in vitro. The leucine-rich repeats (LRRs) are important for potentiation of Wnt7 signaling. The RGD motif is involved in integrin ITGAV:ITGB3 binding. Glycosylated. Proteolytically cleaved into two subunits, an extracellular subunit and a seven-transmembrane subunit. Cleaved by thrombin (F2) and MMP1. Also cleaved by MMP9, with lower efficiency. Presence of the protein disulfide-isomerase P4HB at the cell surface is additionally required for shedding of the extracellular subunit, suggesting that the subunits are linked by disulfide bonds. Shedding is enhanced by the growth factor FGF2 and may promote cell survival during angiogenesis. No viable adults (PubMed:21071672, PubMed:21282641, PubMed:21421844). Beginning at 11 dpc, deficient embryos exhibit completely penetrant, progressive CNS hemorrhage originating in forebrain telencephalon and ventral neural tube leading to embryonic lethality from 15.5 dpc (PubMed:21071672, PubMed:21282641, PubMed:21421844). Embryos at 11.5 dpc display selective CNS-specific vascular patterning defects, with markedly reduced angiogenic sprouting into the forebrain telencephalon and thickening of the underlying periventricular vascular plexus rendering the telencephalon virtually avascular (PubMed:21071672, PubMed:21282641, PubMed:21421844, PubMed:25373781). Remaining CNS vessels show significantly increased permeability (PubMed:21421844). Lung size is reduced in 15.5 dpc embryos (PubMed:21282641). Cleft palate is present at 15.5 dpc or later (PubMed:21282641). Conditional knockout mice lacking Adgra2 in the endothelia of adult mice show blood-brain barrier integrity defects in a stroke model and glioblastoma (PubMed:28288111). Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. It is uncertain whether Met-1 or Met-8 is the initiator. Sequence=AAI38452.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI38453.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAL11996.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; angiogenesis sprouting angiogenesis transmembrane signaling receptor activity G-protein coupled receptor activity plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway central nervous system development cell surface positive regulation of endothelial cell migration membrane integral component of membrane Wnt signaling pathway filopodium cell projection endothelial cell migration regulation of angiogenesis regulation of chemotaxis regulation of establishment of blood-brain barrier positive regulation of canonical Wnt signaling pathway negative regulation of vascular endothelial growth factor signaling pathway Wnt signalosome uc009lhx.1 uc009lhx.2 uc009lhx.3 uc009lhx.4 
ENSMUST00000033877.6 Brf2 ENSMUST00000033877.6 BRF2, RNA polymerase III transcription initiation factor 50kDa subunit (from RefSeq NM_025686.2) A0A0R4J0C6 A0A0R4J0C6_MOUSE Brf2 ENSMUST00000033877.1 ENSMUST00000033877.2 ENSMUST00000033877.3 ENSMUST00000033877.4 ENSMUST00000033877.5 NM_025686 uc009lhy.1 uc009lhy.2 uc009lhy.3 Nucleus transcription factor TFIIIB complex RNA polymerase III type 3 promoter DNA binding translation initiation factor activity regulation of transcription, DNA-templated regulation of transcription from RNA polymerase III promoter translational initiation cellular response to oxidative stress metal ion binding DNA-templated transcriptional preinitiation complex assembly uc009lhy.1 uc009lhy.2 uc009lhy.3 
ENSMUST00000033878.14 Rab11fip1 ENSMUST00000033878.14 RAB11 family interacting protein 1 (class I), transcript variant 2 (from RefSeq NM_029423.2) ENSMUST00000033878.1 ENSMUST00000033878.10 ENSMUST00000033878.11 ENSMUST00000033878.12 ENSMUST00000033878.13 ENSMUST00000033878.2 ENSMUST00000033878.3 ENSMUST00000033878.4 ENSMUST00000033878.5 ENSMUST00000033878.6 ENSMUST00000033878.7 ENSMUST00000033878.8 ENSMUST00000033878.9 NM_029423 Q05A58 Q3UBC2 Q8BN24 Q9D620 RFIP1_MOUSE Rcp uc009lia.1 uc009lia.2 uc009lia.3 uc009lia.4 A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and phagocytosis (By similarity). Homooligomer. Interacts with RAB4A, RAB11A, RAB11B and RAB25 (By similarity). Recycling endosome Cytoplasmic vesicle, phagosome membrane Note=Membrane-bound. RAB11A rather than RAB4A mediates RAB11FIP1 localization in the endocytic recycling compartment (ERC). Colocalizes with RAB11A at phagosomes (By similarity). endosome cytosol protein transport membrane Rab GTPase binding phagocytic vesicle membrane cytoplasmic vesicle intracellular membrane-bounded organelle regulated exocytosis recycling endosome negative regulation of adiponectin secretion uc009lia.1 uc009lia.2 uc009lia.3 uc009lia.4 
ENSMUST00000033880.7 Eif4ebp1 ENSMUST00000033880.7 eukaryotic translation initiation factor 4E binding protein 1 (from RefSeq NM_007918.3) 4EBP1_MOUSE ENSMUST00000033880.1 ENSMUST00000033880.2 ENSMUST00000033880.3 ENSMUST00000033880.4 ENSMUST00000033880.5 ENSMUST00000033880.6 NM_007918 Q3TDS8 Q60876 Q9CZ40 uc009lih.1 uc009lih.2 uc009lih.3 Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7629182). Hypophosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:7629182). Interacts (via TOS motif) with RPTOR; promoting phosphorylation by mTORC1 (PubMed:24139800). Q60876; P63073: Eif4e; NbExp=3; IntAct=EBI-398674, EBI-2000006; Cytoplasm Nucleus Note=Localization to the nucleus is unaffected by phosphorylation status. Highest expression in fat cells. The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex. Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-36, Thr-45, Ser-64 and Thr-69, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E. Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-36, Thr-45, Ser-64 and Thr-69) or associated with eIF4E. Mice lacking both Eif4ebp1 and Eif4ebp2 display increased their sensitivity to diet-induced obesity (PubMed:17273556). Mice lacking both Eif4ebp1 and Eif4ebp2 show defects in myelopoiesis: mice display an increased number of immature granulocytic precursors, associated with a decreased number of mature granulocytic elements (PubMed:19175792). Belongs to the eIF4E-binding protein family. G1/S transition of mitotic cell cycle IRES-dependent translational initiation response to ischemia protein binding nucleus cytoplasm cytosol regulation of translation regulation of translational initiation eukaryotic initiation factor 4E binding insulin receptor signaling pathway negative regulation of translation lung development translation repressor activity negative regulation of protein complex assembly translation initiation factor binding TOR signaling macromolecular complex response to ethanol positive regulation of mitotic cell cycle negative regulation of translational initiation protein phosphatase 2A binding cellular response to hypoxia cellular response to dexamethasone stimulus glutamatergic synapse postsynaptic cytosol response to amino acid starvation uc009lih.1 uc009lih.2 uc009lih.3 
ENSMUST00000033882.10 Chrna6 ENSMUST00000033882.10 cholinergic receptor, nicotinic, alpha polypeptide 6 (from RefSeq NM_021369.2) ACHA6_MOUSE ENSMUST00000033882.1 ENSMUST00000033882.2 ENSMUST00000033882.3 ENSMUST00000033882.4 ENSMUST00000033882.5 ENSMUST00000033882.6 ENSMUST00000033882.7 ENSMUST00000033882.8 ENSMUST00000033882.9 NM_021369 Nica6 Q3UEY4 Q8K0A7 Q9R0W9 uc009liv.1 uc009liv.2 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Interacts with LYPD6. Postsynaptic cell membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-6/CHRNA6 sub- subfamily. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity protein binding plasma membrane integral component of plasma membrane acetylcholine-gated channel complex ion transport signal transduction chemical synaptic transmission synaptic transmission, cholinergic neuromuscular synaptic transmission drug binding regulation of dopamine secretion membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction positive regulation of dopamine secretion ion transmembrane transport response to nicotine regulation of membrane potential neuron projection synapse postsynaptic membrane neurological system process protein heterooligomerization membrane depolarization regulation of postsynaptic membrane potential excitatory postsynaptic potential integral component of postsynaptic membrane integral component of presynaptic membrane regulation of synaptic vesicle exocytosis acetylcholine receptor activity acetylcholine binding uc009liv.1 uc009liv.2 
ENSMUST00000033888.5 Cd209e ENSMUST00000033888.5 CD209e antigen (from RefSeq NM_130905.2) C209E_MOUSE ENSMUST00000033888.1 ENSMUST00000033888.2 ENSMUST00000033888.3 ENSMUST00000033888.4 NM_130905 Q91ZW7 uc009kss.1 uc009kss.2 uc009kss.3 Putative pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Membrane ; Single-pass type II membrane protein In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified. Name=Functional Glycomics Gateway - Glycan Binding; Note=SIGNR4; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_164"; mannose binding plasma membrane endocytosis external side of plasma membrane membrane integral component of membrane carbohydrate binding positive regulation of T cell proliferation B cell adhesion uc009kss.1 uc009kss.2 uc009kss.3 
ENSMUST00000033898.10 Col4a1 ENSMUST00000033898.10 collagen, type IV, alpha 1, transcript variant 1 (from RefSeq NM_009931.2) CO4A1_MOUSE Col4a1 ENSMUST00000033898.1 ENSMUST00000033898.2 ENSMUST00000033898.3 ENSMUST00000033898.4 ENSMUST00000033898.5 ENSMUST00000033898.6 ENSMUST00000033898.7 ENSMUST00000033898.8 ENSMUST00000033898.9 NM_009931 P02463 Q3UHJ4 Q3UJE7 Q3UQV2 Q53X35 Q6GQS7 Q6PHB5 Q99LQ8 uc009kvb.1 uc009kvb.2 uc009kvb.3 This gene encodes the alpha-1 subunit of the type IV collagens, an essential component of basement membranes. The encoded protein forms a triple helical heterotrimer comprised of two alpha-1 and one alpha-2 subunits that assembles into a type IV collagen network. This gene is located adjacent to the gene encoding alpha-2 subunit. Mice lacking both the alpha-1 and alpha-2 subunits of collagen IV die in utero due to structural deficiencies in the basement membranes and certain mutations in this gene cause perinatal cerebral hemorrhage and porencephaly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015]. Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. Interacts with EFEMP2 (PubMed:17324935). Secreted, extracellular space, extracellular matrix, basement membrane Detected in the basement membrane of the cornea (at protein level). Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain. NC1 domain mediates hexamerization of alpha chains of type IV collagen (PubMed:22842973). Lysines at the third position of the tripeptide repeating unit (G- X-Y) are hydroxylated. The modified lysines can be O-glycosylated. Contains 4-hydroxyproline. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Contains 3-hydroxyproline. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4- hydroxyproline. Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. The trimeric structure of the NC1 domains is stabilized by covalent bonds (sulfilimine cross-links) between Lys and Met residues. These cross-links are important for the mechanical stability of the basement membrane (PubMed:28424209, PubMed:22842973). Sulfilimine cross-link is catalyzed by PXDN (PubMed:22842973). Proteolytic processing produces the C-terminal NC1 peptide, arresten. Mice develop perinatal cerebral hemorrhage and porencephaly. The mutant protein inhibits the secretion of mutant and normal proteins into the basement membrane of embryonic origin. The mutation is semidominant. Belongs to the type IV collagen family. Sequence=AAH72650.1; Type=Frameshift; Evidence=; Sequence=AAH72650.1; Type=Miscellaneous discrepancy; Note=Insertion sequence.; Evidence=; angiogenesis branching involved in blood vessel morphogenesis extracellular matrix structural constituent extracellular region collagen trimer collagen type IV trimer basement membrane extracellular space brain development neuromuscular junction development extracellular matrix structural constituent conferring tensile strength extracellular matrix organization epithelial cell differentiation extracellular matrix collagen-activated tyrosine kinase receptor signaling pathway platelet-derived growth factor binding blood vessel morphogenesis retinal blood vessel morphogenesis renal tubule morphogenesis cellular response to amino acid stimulus basement membrane organization uc009kvb.1 uc009kvb.2 uc009kvb.3 
ENSMUST00000033899.14 Col4a2 ENSMUST00000033899.14 collagen, type IV, alpha 2 (from RefSeq NM_009932.5) CO4A2_MOUSE Col4a2 ENSMUST00000033899.1 ENSMUST00000033899.10 ENSMUST00000033899.11 ENSMUST00000033899.12 ENSMUST00000033899.13 ENSMUST00000033899.2 ENSMUST00000033899.3 ENSMUST00000033899.4 ENSMUST00000033899.5 ENSMUST00000033899.6 ENSMUST00000033899.7 ENSMUST00000033899.8 ENSMUST00000033899.9 NM_009932 P08122 Q3B7C2 Q3TPV9 Q61375 Q66JS5 Q6RCT6 Q6RCT7 Q6U9X1 Q8BPI9 Q8BPK3 Q91VI3 uc009kvc.1 uc009kvc.2 uc009kvc.3 uc009kvc.4 This gene encodes the alpha-2 subunit of the type IV collagens, an essential component of basement membranes. The encoded protein forms a triple helical heterotrimer comprised of alpha-1 and alpha-2 subunits that assembles into a type IV collagen network. Canstatin, a peptide derived fom the C-terminus of the collagen chain, is a matrikine that has been shown to inhibit angiogenesis. Homozygous knockout mice for this gene exhibit impaired basement membrane integrity and embryonic lethality. This gene shares a bi-directional promoter with a related gene on chromosome 8. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J04695.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins (By similarity). There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. Interacts with EFEMP2 (PubMed:17324935). Secreted, extracellular space, extracellular matrix, basement membrane Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. Proteolytic processing produces the C-terminal NC1 peptide, canstatin. The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues. Brominated by PXDN. Belongs to the type IV collagen family. Sequence=AAH80789.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 277.; Evidence=; Sequence=AAI07686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 277.; Evidence=; angiogenesis extracellular matrix structural constituent extracellular region collagen trimer collagen type IV trimer basement membrane extracellular space transcription, DNA-templated aging response to activity negative regulation of angiogenesis extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix endodermal cell differentiation collagen-activated tyrosine kinase receptor signaling pathway cellular response to transforming growth factor beta stimulus uc009kvc.1 uc009kvc.2 uc009kvc.3 uc009kvc.4 
ENSMUST00000033900.7 Rab20 ENSMUST00000033900.7 RAB20, member RAS oncogene family (from RefSeq NM_011227.2) ENSMUST00000033900.1 ENSMUST00000033900.2 ENSMUST00000033900.3 ENSMUST00000033900.4 ENSMUST00000033900.5 ENSMUST00000033900.6 NM_011227 Q3TPA7 Q3TPA7_MOUSE Rab20 uc009kvd.1 uc009kvd.2 uc009kvd.3 Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding Golgi apparatus intracellular membrane-bounded organelle phagocytic vesicle phagosome acidification phagosome-lysosome fusion uc009kvd.1 uc009kvd.2 uc009kvd.3 
ENSMUST00000033905.13 Ankrd10 ENSMUST00000033905.13 ankyrin repeat domain 10, transcript variant 1 (from RefSeq NM_133971.3) ANR10_MOUSE ENSMUST00000033905.1 ENSMUST00000033905.10 ENSMUST00000033905.11 ENSMUST00000033905.12 ENSMUST00000033905.2 ENSMUST00000033905.3 ENSMUST00000033905.4 ENSMUST00000033905.5 ENSMUST00000033905.6 ENSMUST00000033905.7 ENSMUST00000033905.8 ENSMUST00000033905.9 NM_133971 Q8BGB6 Q99LW0 uc009kvo.1 uc009kvo.2 uc009kvo.3 uc009kvo.4 uc009kvo.5 molecular_function cellular_component uc009kvo.1 uc009kvo.2 uc009kvo.3 uc009kvo.4 uc009kvo.5 
ENSMUST00000033906.11 Spaca7b ENSMUST00000033906.11 sperm acrosome associated 7B (from RefSeq NM_024271.2) 1700016D06Rik ENSMUST00000033906.1 ENSMUST00000033906.10 ENSMUST00000033906.2 ENSMUST00000033906.3 ENSMUST00000033906.4 ENSMUST00000033906.5 ENSMUST00000033906.6 ENSMUST00000033906.7 ENSMUST00000033906.8 ENSMUST00000033906.9 NM_024271 Q9DAA5 Q9DAA5_MOUSE Spaca7b uc009kvt.1 uc009kvt.2 uc009kvt.3 uc009kvt.4 acrosomal vesicle uc009kvt.1 uc009kvt.2 uc009kvt.3 uc009kvt.4 
ENSMUST00000033909.14 Tex29 ENSMUST00000033909.14 testis expressed 29 (from RefSeq NM_029326.1) ENSMUST00000033909.1 ENSMUST00000033909.10 ENSMUST00000033909.11 ENSMUST00000033909.12 ENSMUST00000033909.13 ENSMUST00000033909.2 ENSMUST00000033909.3 ENSMUST00000033909.4 ENSMUST00000033909.5 ENSMUST00000033909.6 ENSMUST00000033909.7 ENSMUST00000033909.8 ENSMUST00000033909.9 NM_029326 Q9DA77 TEX29_MOUSE uc009kvy.1 uc009kvy.2 uc009kvy.3 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009kvy.1 uc009kvy.2 uc009kvy.3 
ENSMUST00000033910.9 Leprotl1 ENSMUST00000033910.9 leptin receptor overlapping transcript-like 1 (from RefSeq NM_026609.2) ENSMUST00000033910.1 ENSMUST00000033910.2 ENSMUST00000033910.3 ENSMUST00000033910.4 ENSMUST00000033910.5 ENSMUST00000033910.6 ENSMUST00000033910.7 ENSMUST00000033910.8 LERL1_MOUSE NM_026609 Q3U662 Q9CQ74 uc009lkp.1 uc009lkp.2 uc009lkp.3 Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Interacts with RAB13. Membrane ; Multi-pass membrane protein Up-regulated in the liver of fasting animals. Belongs to the OB-RGRP/VPS55 family. molecular_function endosome membrane integral component of membrane late endosome to vacuole transport via multivesicular body sorting pathway negative regulation of protein localization to cell surface uc009lkp.1 uc009lkp.2 uc009lkp.3 
ENSMUST00000033913.11 Dctn6 ENSMUST00000033913.11 dynactin 6, transcript variant 2 (from RefSeq NM_011722.4) DCTN6_MOUSE ENSMUST00000033913.1 ENSMUST00000033913.10 ENSMUST00000033913.2 ENSMUST00000033913.3 ENSMUST00000033913.4 ENSMUST00000033913.5 ENSMUST00000033913.6 ENSMUST00000033913.7 ENSMUST00000033913.8 ENSMUST00000033913.9 NM_011722 Q8C2M9 Q9QZB8 Q9WUB4 Ws3 uc009lko.1 uc009lko.2 uc009lko.3 uc009lko.4 uc009lko.5 uc009lko.6 Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. Within the complex DCTN6 forms a heterodimer with DCTN5 (By similarity). The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin (By similarity). Interacts with PLK1 (By similarity). Cytoplasm, cytoskeleton Chromosome, centromere, kinetochore Up-regulated in Ant1-deficient mice. Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores. Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily. chromosome, centromeric region kinetochore condensed chromosome kinetochore catalytic activity chromosome cytoplasm mitochondrion centrosome cytoskeleton dynactin complex mitochondrion organization mitotic spindle organization lipid biosynthetic process dynein complex binding uc009lko.1 uc009lko.2 uc009lko.3 uc009lko.4 uc009lko.5 uc009lko.6 
ENSMUST00000033915.9 Gpm6a ENSMUST00000033915.9 glycoprotein m6a, transcript variant 1 (from RefSeq NM_153581.6) ENSMUST00000033915.1 ENSMUST00000033915.2 ENSMUST00000033915.3 ENSMUST00000033915.4 ENSMUST00000033915.5 ENSMUST00000033915.6 ENSMUST00000033915.7 ENSMUST00000033915.8 Gpm6a NM_153581 Q542P2 Q542P2_MOUSE uc009lsl.1 uc009lsl.2 uc009lsl.3 uc009lsl.4 Cell projection, dendritic spine Cell projection, filopodium Membrane ; Multi-pass membrane protein Belongs to the myelin proteolipid protein family. neuron migration calcium channel activity plasma membrane synapse assembly membrane integral component of membrane filopodium neuron projection neuronal cell body stem cell differentiation regulation of synapse organization positive regulation of filopodium assembly calcium ion transmembrane transport glutamatergic synapse integral component of presynaptic active zone membrane uc009lsl.1 uc009lsl.2 uc009lsl.3 uc009lsl.4 
ENSMUST00000033917.7 Spata4 ENSMUST00000033917.7 spermatogenesis associated 4 (from RefSeq NM_133711.4) ENSMUST00000033917.1 ENSMUST00000033917.2 ENSMUST00000033917.3 ENSMUST00000033917.4 ENSMUST00000033917.5 ENSMUST00000033917.6 NM_133711 Q8K3V1 Q923U8 SPAT4_MOUSE Srg2 Tsarg2 uc009lsf.1 uc009lsf.2 May play a role in apoptosis regulation. Q8K3V1; Q9CQP2: Trappc2; NbExp=3; IntAct=EBI-7067375, EBI-1172267; Nucleus Testis. molecular_function protein binding nucleus cytoplasm axoneme microtubule binding regulation of cytoskeleton organization uc009lsf.1 uc009lsf.2 
ENSMUST00000033918.4 Asb5 ENSMUST00000033918.4 ankyrin repeat and SOCs box-containing 5, transcript variant 1 (from RefSeq NM_029569.3) ASB5_MOUSE ENSMUST00000033918.1 ENSMUST00000033918.2 ENSMUST00000033918.3 NM_029569 Q9D1A4 uc009lse.1 uc009lse.2 uc009lse.3 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis (By similarity). Protein modification; protein ubiquitination. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Belongs to the ankyrin SOCS box (ASB) family. molecular_function cellular_component protein ubiquitination intracellular signal transduction positive regulation of protein catabolic process uc009lse.1 uc009lse.2 uc009lse.3 
ENSMUST00000033919.6 Vegfc ENSMUST00000033919.6 vascular endothelial growth factor C (from RefSeq NM_009506.2) C6F5S8 C6F5S9 C6F5T0 ENSMUST00000033919.1 ENSMUST00000033919.2 ENSMUST00000033919.3 ENSMUST00000033919.4 ENSMUST00000033919.5 NM_009506 P97953 Q543R6 VEGFC_MOUSE uc009lsc.1 uc009lsc.2 uc009lsc.3 Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. Homodimer; non-covalent and antiparallel (PubMed:9247316). Interacts with FLT4/VEGFR3; the interaction is required for FLT4/VEGFR3 homodimarization and activation (By similarity). P97953-1; O60462: NRP2; Xeno; NbExp=3; IntAct=EBI-16148671, EBI-12586256; Secreted. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Vegf-C; IsoId=P97953-1; Sequence=Displayed; Name=2; Synonyms=Vegf-C184; IsoId=P97953-2; Sequence=VSP_053481, VSP_053482; Name=3; Synonyms=Vegf-C129; IsoId=P97953-3; Sequence=VSP_053479, VSP_053480, VSP_053482; Name=4; Synonyms=Vegf-C62; IsoId=P97953-4; Sequence=VSP_053477, VSP_053478, VSP_053480, VSP_053482; Expressed in adult heart, brain, spleen, lung, liver, skeletal muscle, kidney, testis and intestine with higher levels in heart, brain and kidney. Isoform 4 levels are very low. Isoform 3 is mostly expressed in liver and has reduced expression level in other tissues. Isoform 2 is mostly expressed in brain and kidney, although a lower level expression in other tissues is also detectable. Expression detected in mesenchymal cells of postimplantation embryos, particularly in the regions where the lymphatic vessels undergo sprouting from embryonic veins, such as the perimetanephric, axillary and jugular regions, and in the developing mesenterium. Also detected between vertebral corpuscles, in lung mesenchyme, in neck region and in developing forehead. Not detected in the blood islands of the yolk sac. Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-223 and Ser-224 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non- covalent interactions (By similarity). Belongs to the PDGF/VEGF growth factor family. angiogenesis response to hypoxia positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation positive regulation of cell-matrix adhesion sprouting angiogenesis positive regulation of neuroblast proliferation vascular endothelial growth factor receptor binding protein binding extracellular region extracellular space multicellular organism development growth factor activity positive regulation of cell proliferation negative regulation of cell proliferation animal organ morphogenesis membrane morphogenesis of embryonic epithelium cell differentiation regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of protein autophosphorylation vascular endothelial growth factor signaling pathway chemoattractant activity response to drug vascular endothelial growth factor receptor 3 binding positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis negative regulation of blood pressure vascular endothelial growth factor receptor signaling pathway positive regulation of epithelial cell proliferation positive regulation of protein secretion positive regulation of peptidyl-tyrosine phosphorylation positive chemotaxis induction of positive chemotaxis positive regulation of cell division positive regulation of mast cell chemotaxis positive regulation of lymphangiogenesis cellular response to leukemia inhibitory factor uc009lsc.1 uc009lsc.2 uc009lsc.3 
ENSMUST00000033920.6 Aga ENSMUST00000033920.6 aspartylglucosaminidase, transcript variant 1 (from RefSeq NM_001005847.3) ASPG_MOUSE ENSMUST00000033920.1 ENSMUST00000033920.2 ENSMUST00000033920.3 ENSMUST00000033920.4 ENSMUST00000033920.5 NM_001005847 Q64191 uc009lrz.1 uc009lrz.2 uc009lrz.3 uc009lrz.4 This gene encodes an amidase enzyme that participates in the breakdown of glycoproteins in the cell. The encoded protein undergoes proteolytic processing to generate a mature enzyme. Mice lacking the encoded protein exhibit accumulation of aspartylglucosamine along with lysosomal vacuolization, axonal swelling in the gracile nucleus and impaired neuromotor coordination. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]. Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. Reaction=H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine; Xref=Rhea:RHEA:11544, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15947, ChEBI:CHEBI:29991, ChEBI:CHEBI:58080; EC=3.5.1.26; Evidence=; Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers. Lysosome. Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme (PubMed:8586423). The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity. N-glycosylated. Belongs to the Ntn-hydrolase family. N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity extracellular space cytoplasm lysosome endoplasmic reticulum proteolysis protein deglycosylation peptidase activity hydrolase activity protein self-association uc009lrz.1 uc009lrz.2 uc009lrz.3 uc009lrz.4 
ENSMUST00000033923.14 Dlc1 ENSMUST00000033923.14 deleted in liver cancer 1, transcript variant 2 (from RefSeq NM_015802.3) Dlc1 E9QKB1 E9QKB1_MOUSE ENSMUST00000033923.1 ENSMUST00000033923.10 ENSMUST00000033923.11 ENSMUST00000033923.12 ENSMUST00000033923.13 ENSMUST00000033923.2 ENSMUST00000033923.3 ENSMUST00000033923.4 ENSMUST00000033923.5 ENSMUST00000033923.6 ENSMUST00000033923.7 ENSMUST00000033923.8 ENSMUST00000033923.9 NM_015802 uc009llq.1 uc009llq.2 uc009llq.3 uc009llq.4 Cell junction, focal adhesion Membrane ; Peripheral membrane protein GTPase activator activity signal transduction lipid binding regulation of Rho protein signal transduction positive regulation of GTPase activity uc009llq.1 uc009llq.2 uc009llq.3 uc009llq.4 
ENSMUST00000033927.8 Eri1 ENSMUST00000033927.8 exoribonuclease 1 (from RefSeq NM_026067.3) A0A0R4J0C8 A0A0R4J0C8_MOUSE ENSMUST00000033927.1 ENSMUST00000033927.2 ENSMUST00000033927.3 ENSMUST00000033927.4 ENSMUST00000033927.5 ENSMUST00000033927.6 ENSMUST00000033927.7 Eri1 NM_026067 uc009lky.1 uc009lky.2 uc009lky.3 uc009lky.4 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm nucleic acid binding nucleolus cytoplasm 3'-5' exonuclease activity nucleic acid phosphodiester bond hydrolysis uc009lky.1 uc009lky.2 uc009lky.3 uc009lky.4 
ENSMUST00000033929.6 Tnks ENSMUST00000033929.6 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (from RefSeq NM_175091.3) ENSMUST00000033929.1 ENSMUST00000033929.2 ENSMUST00000033929.3 ENSMUST00000033929.4 ENSMUST00000033929.5 NM_175091 Q6PFX9 Q8BX62 TNKS1_MOUSE Tnks1 uc009lkv.1 uc009lkv.2 uc009lkv.3 Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly- ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity. Reaction=NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H(+).; EC=2.4.2.30; Evidence=; Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA- COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=; Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence=; Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2. Interacts with AXIN1. Interacts with AXIN2. Interacts with BLZF1 and CASC3. Interacts with NUMA1. Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus, nuclear pore complex Chromosome, telomere Cytoplasm, cytoskeleton, spindle pole Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PFX9-1; Sequence=Displayed; Name=2; IsoId=Q6PFX9-2; Sequence=VSP_041320; Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis. Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. Belongs to the ARTD/PARP family. Golgi membrane protein polyubiquitination chromosome, telomeric region nuclear chromosome, telomeric region spindle pole NAD+ ADP-ribosyltransferase activity nucleus nuclear pore nucleoplasm chromosome cytoplasm Golgi apparatus microtubule organizing center cytosol cytoskeleton protein ADP-ribosylation cell cycle zinc ion binding protein transport membrane Wnt signaling pathway nuclear body transferase activity transferase activity, transferring glycosyl groups peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cellular response to nutrient nuclear membrane positive regulation of telomere maintenance via telomerase histone binding positive regulation of transcription from RNA polymerase II promoter metal ion binding mRNA transport spindle assembly cell division positive regulation of telomerase activity protein localization to chromosome, telomeric region protein poly-ADP-ribosylation protein auto-ADP-ribosylation positive regulation of canonical Wnt signaling pathway mitotic spindle pole positive regulation of telomere capping negative regulation of telomere maintenance via telomere lengthening negative regulation of telomeric DNA binding negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric protein ADP-ribosylase activity uc009lkv.1 uc009lkv.2 uc009lkv.3 
ENSMUST00000033930.5 Dusp4 ENSMUST00000033930.5 dual specificity phosphatase 4, transcript variant 1 (from RefSeq NM_176933.5) DUS4_MOUSE ENSMUST00000033930.1 ENSMUST00000033930.2 ENSMUST00000033930.3 ENSMUST00000033930.4 NM_176933 Q8BFV3 uc009lks.1 uc009lks.2 uc009lks.3 Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Hollow spherical complex composed of 24 subunits with pseudooctahedral symmetry, has a tetramer as the basic unit. Nucleus Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. inactivation of MAPK activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus nucleoplasm cytoplasm protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity peptidyl-tyrosine dephosphorylation peptidyl-threonine dephosphorylation negative regulation of ERK1 and ERK2 cascade MAP kinase threonine phosphatase activity uc009lks.1 uc009lks.2 uc009lks.3 
ENSMUST00000033934.5 Mrps31 ENSMUST00000033934.5 mitochondrial ribosomal protein S31 (from RefSeq NM_020560.2) ENSMUST00000033934.1 ENSMUST00000033934.2 ENSMUST00000033934.3 ENSMUST00000033934.4 Imogn38 NM_020560 Q3TSP5 Q61733 Q8VEH4 Q9D045 RT31_MOUSE uc009ldc.1 uc009ldc.2 uc009ldc.3 uc009ldc.4 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mS31 family. structural constituent of ribosome nucleolus mitochondrion mitochondrial small ribosomal subunit ribosome biological_process protein domain specific binding uc009ldc.1 uc009ldc.2 uc009ldc.3 uc009ldc.4 
ENSMUST00000033935.16 Smim19 ENSMUST00000033935.16 small integral membrane protein 19, transcript variant 2 (from RefSeq NM_001146117.2) ENSMUST00000033935.1 ENSMUST00000033935.10 ENSMUST00000033935.11 ENSMUST00000033935.12 ENSMUST00000033935.13 ENSMUST00000033935.14 ENSMUST00000033935.15 ENSMUST00000033935.2 ENSMUST00000033935.3 ENSMUST00000033935.4 ENSMUST00000033935.5 ENSMUST00000033935.6 ENSMUST00000033935.7 ENSMUST00000033935.8 ENSMUST00000033935.9 NM_001146117 Q80ZU4 SMI19_MOUSE uc009lde.1 uc009lde.2 uc009lde.3 uc009lde.4 Membrane ; Single-pass membrane protein Belongs to the SMIM19 family. Sequence=AAH48089.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE20860.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE21793.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE24529.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function biological_process membrane integral component of membrane uc009lde.1 uc009lde.2 uc009lde.3 uc009lde.4 
ENSMUST00000033936.8 Dkk4 ENSMUST00000033936.8 dickkopf WNT signaling pathway inhibitor 4 (from RefSeq NM_145592.2) DKK4_MOUSE ENSMUST00000033936.1 ENSMUST00000033936.2 ENSMUST00000033936.3 ENSMUST00000033936.4 ENSMUST00000033936.5 ENSMUST00000033936.6 ENSMUST00000033936.7 NM_145592 Q8VEJ3 uc009ldj.1 uc009ldj.2 uc009ldj.3 Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). Interacts with LRP5 and LRP6. Secreted The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6. Belongs to the dickkopf family. extracellular region extracellular space multicellular organism development Wnt signaling pathway negative regulation of Wnt signaling pathway co-receptor binding receptor antagonist activity negative regulation of hair follicle placode formation negative regulation of canonical Wnt signaling pathway negative regulation of receptor activity uc009ldj.1 uc009ldj.2 uc009ldj.3 
ENSMUST00000033938.7 Polb ENSMUST00000033938.7 polymerase (DNA directed), beta (from RefSeq NM_011130.2) DPOLB_MOUSE ENSMUST00000033938.1 ENSMUST00000033938.2 ENSMUST00000033938.3 ENSMUST00000033938.4 ENSMUST00000033938.5 ENSMUST00000033938.6 NM_011130 Q3UAB6 Q8K409 Q922Z7 uc009ldk.1 uc009ldk.2 uc009ldk.3 uc009ldk.4 Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose- phosphate from the preincised AP site acting as a 5'-deoxyribose- phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase. Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence=; Reaction=a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)- 4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-monophospho-2'- deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:76255, Rhea:RHEA- COMP:13180, Rhea:RHEA-COMP:18657, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:195194, ChEBI:CHEBI:195195; Evidence=; Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA- COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695, ChEBI:CHEBI:167181; EC=4.2.99.18; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions per subunit. ; Monomer (By similarity). Binds single-stranded DNA (ssDNA) (By similarity). Interacts with APEX1, LIG1, LIG3, FEN1, PCNA and XRCC1 (By similarity). Interacts with HUWE1/ARF-BP1, STUB1/CHIP and USP47 (By similarity). Interacts with FAM168A (By similarity). Nucleus Cytoplasm Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage. Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity. Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity. Ubiquitinated at Lys-41, Lys-61 and Lys-81: monoubiquitinated by HUWE1/ARF-BP1. Monoubiquitinated protein is then the target of STUB1/CHIP, which catalyzes polyubiquitination from monoubiquitin, leading to degradation by the proteasome. USP47 mediates the deubiquitination of monoubiquitinated protein, preventing polyubiquitination by STUB1/CHIP and its subsequent degradation (By similarity). Belongs to the DNA polymerase type-X family. Sequence=AAH06681.1; Type=Frameshift; Evidence=; synaptonemal complex in utero embryonic development DNA binding damaged DNA binding DNA-directed DNA polymerase activity nucleus cytoplasm microtubule spindle microtubule DNA replication DNA repair base-excision repair base-excision repair, gap-filling pyrimidine dimer repair double-strand break repair via nonhomologous end joining apoptotic process inflammatory response cellular response to DNA damage stimulus salivary gland morphogenesis aging microtubule binding intrinsic apoptotic signaling pathway in response to DNA damage response to gamma radiation somatic diversification of immunoglobulins somatic hypermutation of immunoglobulin genes transferase activity nucleotidyltransferase activity lyase activity enzyme binding macromolecular complex DNA polymerase activity response to ethanol metal ion binding lymph node development spleen development homeostasis of number of cells neuron apoptotic process response to hyperoxia immunoglobulin heavy chain V-D-J recombination DNA biosynthetic process uc009ldk.1 uc009ldk.2 uc009ldk.3 uc009ldk.4 
ENSMUST00000033939.13 Ikbkb ENSMUST00000033939.13 inhibitor of kappaB kinase beta, transcript variant 10 (from RefSeq NR_188959.1) ENSMUST00000033939.1 ENSMUST00000033939.10 ENSMUST00000033939.11 ENSMUST00000033939.12 ENSMUST00000033939.2 ENSMUST00000033939.3 ENSMUST00000033939.4 ENSMUST00000033939.5 ENSMUST00000033939.6 ENSMUST00000033939.7 ENSMUST00000033939.8 ENSMUST00000033939.9 IKK-2 IKK-beta IKK2 IKK[b] Ikbkb NR_188959 Q5D0E0 Q5D0E0_MOUSE uc009ldm.1 uc009ldm.2 uc009ldm.3 uc009ldm.4 Reaction=ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L- seryl-[I-kappa-B protein]; Xref=Rhea:RHEA:19073, Rhea:RHEA- COMP:13698, Rhea:RHEA-COMP:13699, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.10; Evidence=; Cytoplasm Nucleus protein kinase activity protein serine/threonine kinase activity ATP binding cytosol protein phosphorylation I-kappaB kinase/NF-kappaB signaling I-kappaB phosphorylation IkappaB kinase activity kinase activity phosphorylation peptidyl-serine phosphorylation protein kinase binding cortical actin cytoskeleton organization tumor necrosis factor-mediated signaling pathway negative regulation of myosin-light-chain-phosphatase activity regulation of phosphorylation identical protein binding protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway cellular response to tumor necrosis factor protein localization to plasma membrane scaffold protein binding regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly uc009ldm.1 uc009ldm.2 uc009ldm.3 uc009ldm.4 
ENSMUST00000033941.7 Plat ENSMUST00000033941.7 plasminogen activator, tissue (from RefSeq NM_008872.3) ENSMUST00000033941.1 ENSMUST00000033941.2 ENSMUST00000033941.3 ENSMUST00000033941.4 ENSMUST00000033941.5 ENSMUST00000033941.6 NM_008872 P11214 Q6P7U0 Q91VP2 TPA_MOUSE uc009ldx.1 uc009ldx.2 uc009ldx.3 uc009ldx.4 uc009ldx.5 This gene encodes a key enzyme of the fibrinolytic pathway. The encoded protein undergoes proteolytic processing by plasmin to generate a heterodimeric serine protease that cleaves the proenzyme plasminogen to produce plasmin, a protease that is required to break down fibrin clots. Additionally, the encoded protein is involved in other biological processes such as synaptic plasticity, cell migration and tissue remodeling. Mice lacking the encoded protein display a reduction in long-term potentiation in hippocampus and conversely, transgenic mice overexpressing the encoded protein have increased and prolonged long-term potentiation. [provided by RefSeq, Jul 2015]. Sequence Note: Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used in the 5' UTR of the transcript record were based on data published in PMID: 2542775. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011256.1, AK159620.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity). Reaction=Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.; EC=3.4.21.68; Inhibited by SERPINA5. Heterodimer of chain A and chain B held by a disulfide bond. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Binds LRP1B; binding is followed by internalization and degradation. Forms heterodimer with SERPINA5 (By similarity). In complex with SERPINE1, interacts with SORL1 (By similarity). Secreted, extracellular space. Both FN1 and one of the kringle domains are required for binding to fibrin. Both FN1 and EGF-like domains are important for binding to LRP1. The FN1 domain mediates binding to annexin A2. The second kringle domain is implicated in binding to cytokeratin-8 and to the endothelial cell surface binding site. The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg- 308 catalyzed by plasmin, tissue kallikrein or factor Xa. Belongs to the peptidase S1 family. response to hypoxia serine-type endopeptidase activity receptor binding extracellular region extracellular space cytoplasm proteolysis peptidase activity serine-type peptidase activity cell surface smooth muscle cell migration hydrolase activity secretory granule plasminogen activation synaptic transmission, glutamatergic apical part of cell synapse negative regulation of proteolysis platelet-derived growth factor receptor signaling pathway phosphoprotein binding positive regulation of ovulation postsynapse glutamatergic synapse neuronal dense core vesicle perisynaptic space uc009ldx.1 uc009ldx.2 uc009ldx.3 uc009ldx.4 uc009ldx.5 
ENSMUST00000033950.7 Gins4 ENSMUST00000033950.7 GINS complex subunit 4 (from RefSeq NM_024240.6) ENSMUST00000033950.1 ENSMUST00000033950.2 ENSMUST00000033950.3 ENSMUST00000033950.4 ENSMUST00000033950.5 ENSMUST00000033950.6 NM_024240 Q3TP06 Q99LZ3 SLD5_MOUSE Sld5 uc009ler.1 uc009ler.2 uc009ler.3 uc009ler.4 Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex. Associated with ORC2. Interacts with HELB. Nucleus Chromosome Cytoplasm Highly abundant in testis. Weakly expressed in thymus and bone marrow. Belongs to the GINS4/SLD5 family. double-strand break repair via break-induced replication GINS complex inner cell mass cell proliferation protein binding nucleus cytoplasm DNA replication DNA-dependent DNA replication replication fork protection complex DNA duplex unwinding 3'-5' DNA helicase activity uc009ler.1 uc009ler.2 uc009ler.3 uc009ler.4 
ENSMUST00000033952.8 Sfrp1 ENSMUST00000033952.8 secreted frizzled-related protein 1 (from RefSeq NM_013834.3) ENSMUST00000033952.1 ENSMUST00000033952.2 ENSMUST00000033952.3 ENSMUST00000033952.4 ENSMUST00000033952.5 ENSMUST00000033952.6 ENSMUST00000033952.7 NM_013834 O08861 Q505A2 Q8C4U3 Q8R1J4 SFRP1_MOUSE Sfrp1 uc009lev.1 uc009lev.2 uc009lev.3 Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription (By similarity). Interacts with WNT8, WNT1, WNT2, WNT4 and FRZD6 (By similarity). Interacts with MYOC. Secreted Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding (By similarity). Highly expressed in kidney and embryonic heart. Also highly expressed in the eye, where it is principally localized to the ciliary body and the lens epithelium. Weaker expression in heart, lung and brain. In the brain, is expressed exclusively in the choroid plexus. In the developing kidney expressed at 13.5 dpc in the periphery of the metanophros and surrounding the uretic and nephrogenic tubules. At 14.5 dpc, expression decreases in the outer cortical cells and becomes visible in the tubular parts of the nephron. From 15.5 dpc, highly expressed in the future loops of Henle. In the developing CNS, expression located to the forebrain and hindbrain. At 8.0 dpc, expressed in the future forebrain and in the ventral portion of the presumptive hindbrain. At 8.5 dpc, expression is maintained in these tissues with a strong signal in rhombomere 4. Until 11.5 dpc, expression continues in the hindbrain with additional expression at 9.5 dpc and 10.5 dpc, in the nasal and epibranchial placodes. In the forebrain, initial expression is found in the proencephalon of the forebrain, and then strong expression in the telencephalic vesicle up to 15.5 dpc. Expression is then found in specific cell populations throughout the brain. In the developing eye, expression, by 10.5 dpc, is confined to ectodermal cells overlying the dorsal part of the optic cup. In later stages, expression limited to the lens fiber cells and the future pigmented retina. By 15.5 dpc, expression is confined to the anterior part of the lens. During limb development, barely expressed until later stages, when it is found in the distal part of the separating phalanges. In other developing structures, expressed in nasal placodes at 9.5 dpc, in medial nasal processes at 10.5 dpc and then in the anterior portion of the invaginating olfactory epithelium. At 15.5 dpc, expressed on the basal side of the nasal epithelium. Expressed in the mandibular molar tooth mesenchyme at 13.5 dpc (PubMed:27713059). Expressed in developing teeth, with the highest levels at 15.5 dpc and 16.5 dpc in the mesenchyme and the dental epithelium of the developing molars. As well, expressed in the ventral body wall, in the mesenchyme derived adrenal cortex, the cochlear epithelium and the branching epithelium of the salivary gland. In the developing heart, weakly expressed from 8.5 dpc in the tubular heart endocardium and myocardium. From 8.5 dpc to 12.5 dpc expressed in cardiomyocytes. At 9.5 dpc, expression found in the common ventricular and atrial chamber of the developing heart, in the aortic sac and in the sinus venosus. High expression found from 11.5 dpc-12.5 dpc, in the trabeculated wall of the ventricular chamber together with the wall of the atrial chamber. Expression also found in the muscular part of the interventricular septum. From 9.5 dpc-11.5 dpc expression in the visceral yolk sac confined to the inner lining endothelial cell layer. Expression in the developing heart decreases after 14.5 dpc. The FZ domain is involved in binding with Wnt ligands. Belongs to the secreted frizzled-related protein (sFRP) family. osteoblast differentiation ureteric bud development somitogenesis neural tube closure hematopoietic progenitor cell differentiation cysteine-type endopeptidase activity frizzled binding protein binding extracellular region extracellular space cytosol plasma membrane proteolysis multicellular organism development drug binding heparin binding positive regulation of cell proliferation negative regulation of cell proliferation male gonad development female gonad development cellular response to starvation dorsal/ventral axis specification anterior/posterior pattern specification cell surface regulation of cell cycle process negative regulation of gene expression negative regulation of epithelial to mesenchymal transition regulation of neuron projection development neural crest cell fate commitment response to organic cyclic compound Wnt signaling pathway Wnt-protein binding neural tube development actin cytoskeleton organization hemopoiesis cell differentiation positive regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway regulation of ossification negative regulation of ossification positive regulation of cell growth negative regulation of cell growth negative regulation of cell migration negative regulation of BMP signaling pathway negative regulation of osteoblast proliferation substrate adhesion-dependent cell spreading somatic stem cell population maintenance non-canonical Wnt signaling pathway response to drug identical protein binding positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of JUN kinase activity cellular response to fibroblast growth factor stimulus stromal-epithelial cell signaling involved in prostate gland development negative regulation of B cell differentiation positive regulation of fat cell differentiation negative regulation of osteoblast differentiation negative regulation of osteoclast differentiation positive regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated development of primary male sexual characteristics negative regulation of insulin secretion negative regulation of bone remodeling negative regulation of fibroblast proliferation digestive tract morphogenesis positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of peptidyl-tyrosine phosphorylation canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway hematopoietic stem cell differentiation bone trabecula formation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis regulation of branching involved in prostate gland morphogenesis negative regulation of androgen receptor signaling pathway cellular response to vitamin D cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to growth factor stimulus cellular response to prostaglandin E stimulus cellular response to estrogen stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to X-ray cellular response to heparin dopaminergic neuron differentiation cellular response to transforming growth factor beta stimulus cellular response to BMP stimulus negative regulation of canonical Wnt signaling pathway regulation of establishment of planar polarity planar cell polarity pathway involved in neural tube closure Wnt signaling pathway involved in somitogenesis convergent extension involved in somitogenesis positive regulation of canonical Wnt signaling pathway positive regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of midbrain dopaminergic neuron differentiation negative regulation of planar cell polarity pathway involved in axis elongation positive regulation of non-canonical Wnt signaling pathway negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation negative regulation of fibroblast apoptotic process positive regulation of fibroblast apoptotic process positive regulation of extrinsic apoptotic signaling pathway uc009lev.1 uc009lev.2 uc009lev.3 
ENSMUST00000033956.7 Ido1 ENSMUST00000033956.7 indoleamine 2,3-dioxygenase 1, transcript variant 1 (from RefSeq NM_008324.3) ENSMUST00000033956.1 ENSMUST00000033956.2 ENSMUST00000033956.3 ENSMUST00000033956.4 ENSMUST00000033956.5 ENSMUST00000033956.6 I23O1_MOUSE Ido Ido1 Indo NM_008324 P28776 uc009lfa.1 uc009lfa.2 uc009lfa.3 uc009lfa.4 Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity (PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection (PubMed:15063630). Reaction=D-tryptophan + O2 = N-formyl-D-kynurenine; Xref=Rhea:RHEA:14189, ChEBI:CHEBI:15379, ChEBI:CHEBI:57719, ChEBI:CHEBI:60051; EC=1.13.11.52; Evidence=; Reaction=L-tryptophan + O2 = N-formyl-L-kynurenine; Xref=Rhea:RHEA:24536, ChEBI:CHEBI:15379, ChEBI:CHEBI:57912, ChEBI:CHEBI:58629; EC=1.13.11.52; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 1 heme group per subunit. ; Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by L-1MT (1- methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan). Kinetic parameters: KM=28.1 uM for L-tryptophan ; KM=2.87 mM for D-tryptophan ; Note=Catalytic efficiency for L-tryptophan is 90 times higher than for D-tryptophan.; Monomer. P28776; P35235: Ptpn11; NbExp=5; IntAct=EBI-4410822, EBI-397236; Cytoplasm, cytosol Highly expressed in epididymis, duodemum, jejunum, ileum, colon and spleen (PubMed:19741271). Highly expressed in epididymis, prostate, duodemum, jejunum, ileum, colon and spleen, not detected in the liver (at protein level) (PubMed:19741271). Expressed in tumors only upon exposure to IFN gamma (PubMed:25691885). Constitutively expressed in placenta in trophoblast cells (PubMed:15063630). Expression is restricted to perinuclear regions of primary trophoblast giant cells (TGCs) of fetal origin at mid-gestation (10.5 dpc). After placentation (14 dpc), no IDO expression was detected at the maternal-fetal interface (PubMed:15063630). By IFNG/IFN-gamma in most cells. Knockout mice display normal development and function of dendritic cells, on T- or B-cells development (PubMed:18384884). They display increased sensitivity to the induction of inflammatory and autoimmune reactions (PubMed:22157149). They produce litters of normal sizes at normal rates, implying that compensatory or redundant immunosuppressive mechanisms protected allogeneic fetuses during gestation in knockout mice. Knockout mice display cardiac and gastrointestinal liabilities (PubMed:22157149). Ido1 and Ido2 are 2 distinct enzymes which catalyze the same reaction. Ido2 affinity for tryptophan is much lower than that of Ido1. Ido2 may play a role as a negative regulator of Ido1 by competing for heme-binding with Ido1. Low efficiency Ido2 enzymes have been conserved throughout vertebrate evolution, whereas higher efficiency Ido1 enzymes are dispensable in many lower vertebrate lineages. Ido1 may have arisen by gene duplication of a more ancient proto-IDO gene before the divergence of marsupial and eutherian (placental) mammals. Belongs to the indoleamine 2,3-dioxygenase family. immune system process cytokine production involved in inflammatory response positive regulation of T cell tolerance induction positive regulation of chronic inflammatory response positive regulation of type 2 immune response tryptophan 2,3-dioxygenase activity protein binding cytoplasm cytosol tryptophan catabolic process defense response inflammatory response oxidoreductase activity amino acid binding tryptophan catabolic process to kynurenine oxygen binding heme binding smooth muscle contractile fiber stereocilium bundle response to lipopolysaccharide negative regulation of interleukin-10 production positive regulation of interleukin-12 production multicellular organismal response to stress indoleamine 2,3-dioxygenase activity kynurenic acid biosynthetic process 'de novo' NAD biosynthetic process from tryptophan swimming behavior negative regulation of T cell proliferation positive regulation of apoptotic process negative regulation of activated T cell proliferation metal ion binding dioxygenase activity oxidation-reduction process negative regulation of T cell apoptotic process positive regulation of T cell apoptotic process uc009lfa.1 uc009lfa.2 uc009lfa.3 uc009lfa.4 
ENSMUST00000033957.12 Adam18 ENSMUST00000033957.12 a disintegrin and metallopeptidase domain 18, transcript variant 2 (from RefSeq NR_136908.1) ADA18_MOUSE Adam27 Dtgn3 ENSMUST00000033957.1 ENSMUST00000033957.10 ENSMUST00000033957.11 ENSMUST00000033957.2 ENSMUST00000033957.3 ENSMUST00000033957.4 ENSMUST00000033957.5 ENSMUST00000033957.6 ENSMUST00000033957.7 ENSMUST00000033957.8 ENSMUST00000033957.9 NR_136908 Q60621 Q80Y08 Q9R157 Tmdc3 uc009lfb.1 uc009lfb.2 uc009lfb.3 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during early stages of spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of related ADAM genes on chromosome 8. [provided by RefSeq, May 2016]. ##Evidence-Data-START## Transcript exon combination :: BC144841.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849381, SAMN00849383 [ECO:0000350] ##Evidence-Data-END## Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein. Membrane; Single-pass type I membrane protein. Expressed specifically in testis. Adult levels are reached by day 16 after birth. A tripeptide motif (ECD) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding. The prodomain and the metalloprotease-like domain are cleaved during the epididymal maturation of the spermatozoa. metalloendopeptidase activity integrin binding cellular_component proteolysis multicellular organism development spermatogenesis metallopeptidase activity membrane integral component of membrane cell differentiation uc009lfb.1 uc009lfb.2 uc009lfb.3 
ENSMUST00000033958.15 Adam3 ENSMUST00000033958.15 ADAM metallopeptidase domain 3, transcript variant 1 (from RefSeq NM_009619.5) ADAM3_MOUSE Adam3 Cyrn1 ENSMUST00000033958.1 ENSMUST00000033958.10 ENSMUST00000033958.11 ENSMUST00000033958.12 ENSMUST00000033958.13 ENSMUST00000033958.14 ENSMUST00000033958.2 ENSMUST00000033958.3 ENSMUST00000033958.4 ENSMUST00000033958.5 ENSMUST00000033958.6 ENSMUST00000033958.7 ENSMUST00000033958.8 ENSMUST00000033958.9 F8VQ03 NM_009619 uc009lfc.1 uc009lfc.2 uc009lfc.3 uc009lfc.4 Involved in fertilization by controlling sperm migration into the oviduct (PubMed:19339711). Promotes the binding of sperm to the oocyte zona pellucida (PubMed:32529245). Interacts with LY6K (PubMed:24501175). Interacts with TEX101 (PubMed:23633567). Cell membrane ; Single-pass membrane protein Note=Localized in round and elongating spermatids. Localized on the anterior part of the sperm head, and is removed during the acrosome reaction. Expressed in sperm (at protein level). Initially synthesized as a 110-kDa precursor in round spermatids, and the precursor is then processed into a 42-kDa mature protein during the sperm transport into and/or once in the epididymis. Binding of spermatozoa to the zona pellucida is significantly reduced in vitro, however oocyte fertilization was still able to occur. There are two genes in human, ADAM3A and ADAM3B that are non- functional (PubMed:11439107). ADAM3A gene is deleted in infertile men and in some fertile men. ADAM3B transcripts, from testicular RNA of ADAM3A-deficient men, present many stop codons in all possible reading frames. Moreover these two proteins are neither detected in extracts from the testis of a man with the ADAM3A-positive genotype, nor of a man with a ADAM3A-deficient genotype. metalloendopeptidase activity protein binding plasma membrane proteolysis single fertilization binding of sperm to zona pellucida metallopeptidase activity fertilization cell surface positive regulation of gene expression membrane integral component of membrane flagellated sperm motility macromolecular complex membrane raft regulation of mRNA processing uc009lfc.1 uc009lfc.2 uc009lfc.3 uc009lfc.4 
ENSMUST00000033961.7 Tm2d2 ENSMUST00000033961.7 TM2 domain containing 2 (from RefSeq NM_027194.3) ENSMUST00000033961.1 ENSMUST00000033961.2 ENSMUST00000033961.3 ENSMUST00000033961.4 ENSMUST00000033961.5 ENSMUST00000033961.6 NM_027194 Q8BJJ1 Q8R0I4 Q9CWL9 TM2D2_MOUSE uc009lfn.1 uc009lfn.2 uc009lfn.3 Membrane ; Multi-pass membrane protein Belongs to the TM2 family. molecular_function cellular_component biological_process membrane integral component of membrane uc009lfn.1 uc009lfn.2 uc009lfn.3 
ENSMUST00000033965.14 Tenm3 ENSMUST00000033965.14 teneurin transmembrane protein 3, transcript variant 1 (from RefSeq NM_011857.3) ENSMUST00000033965.1 ENSMUST00000033965.10 ENSMUST00000033965.11 ENSMUST00000033965.12 ENSMUST00000033965.13 ENSMUST00000033965.2 ENSMUST00000033965.3 ENSMUST00000033965.4 ENSMUST00000033965.5 ENSMUST00000033965.6 ENSMUST00000033965.7 ENSMUST00000033965.8 ENSMUST00000033965.9 G3X907 G3X907_MOUSE NM_011857 Odz3 Tenm3 uc009lrs.1 uc009lrs.2 uc009lrs.3 uc009lrs.4 Cell membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein Belongs to the tenascin family. Teneurin subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. integral component of plasma membrane signal transduction membrane integral component of membrane camera-type eye morphogenesis uc009lrs.1 uc009lrs.2 uc009lrs.3 uc009lrs.4 
ENSMUST00000033973.14 Rwdd4a ENSMUST00000033973.14 RWD domain containing 4A (from RefSeq NM_203507.3) ENSMUST00000033973.1 ENSMUST00000033973.10 ENSMUST00000033973.11 ENSMUST00000033973.12 ENSMUST00000033973.13 ENSMUST00000033973.2 ENSMUST00000033973.3 ENSMUST00000033973.4 ENSMUST00000033973.5 ENSMUST00000033973.6 ENSMUST00000033973.7 ENSMUST00000033973.8 ENSMUST00000033973.9 NM_203507 Q9CPR1 RWDD4_MOUSE Rwdd4 uc033jfn.1 uc033jfn.2 uc033jfn.3 molecular_function cellular_component biological_process uc033jfn.1 uc033jfn.2 uc033jfn.3 
ENSMUST00000033975.9 Ddhd2 ENSMUST00000033975.9 DDHD domain containing 2, transcript variant 1 (from RefSeq NM_028102.2) DDHD2_MOUSE Ddhd2 E9QKK2 ENSMUST00000033975.1 ENSMUST00000033975.2 ENSMUST00000033975.3 ENSMUST00000033975.4 ENSMUST00000033975.5 ENSMUST00000033975.6 ENSMUST00000033975.7 ENSMUST00000033975.8 Kiaa0725 NM_028102 Q0VF66 Q6A008 Q80Y98 Q9CVE9 Samwd1 uc009lgv.1 uc009lgv.2 uc009lgv.3 uc009lgv.4 Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3- phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane (By similarity). Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)- octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+); Xref=Rhea:RHEA:45128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74546, ChEBI:CHEBI:77593; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45129; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate; Xref=Rhea:RHEA:40943, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64839, ChEBI:CHEBI:77593; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40944; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + H(+) + hexadecanoate; Xref=Rhea:RHEA:45132, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73007, ChEBI:CHEBI:76088; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45133; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L- serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate; Xref=Rhea:RHEA:43968, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:75029, ChEBI:CHEBI:77342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43969; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:38783, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73001, ChEBI:CHEBI:76071; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38784; Evidence=; Forms homooligomers and, to a much smaller extent, heterooligomers with DDHD1. Cytoplasm, cytosol Endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus, cis-Golgi network Note=Cycles between the Golgi apparatus and the cytosol. DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is regulated by the levels of phosphoinositides, including PI(4)P (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80Y98-1; Sequence=Displayed; Name=2; IsoId=Q80Y98-2; Sequence=VSP_029141, VSP_029143; Name=3; IsoId=Q80Y98-3; Sequence=VSP_029142, VSP_029144; SAM and DDHD domains together are required for phospholipid binding. Belongs to the PA-PLA1 family. It is uncertain whether Met-1 or Met-31 is the initiator. Sequence=AAH46229.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAI18963.1; Type=Frameshift; Evidence=; Sequence=BAD32288.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; phospholipase activity triglyceride lipase activity cytoplasm endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus microtubule organizing center cytosol lipid metabolic process ER to Golgi vesicle-mediated transport locomotory behavior visual learning membrane lipid catabolic process hydrolase activity triglyceride catabolic process ER to Golgi transport vesicle lipid particle organization metal ion binding positive regulation of mitochondrial fission uc009lgv.1 uc009lgv.2 uc009lgv.3 uc009lgv.4 
ENSMUST00000033979.6 Star ENSMUST00000033979.6 steroidogenic acute regulatory protein (from RefSeq NM_011485.5) ENSMUST00000033979.1 ENSMUST00000033979.2 ENSMUST00000033979.3 ENSMUST00000033979.4 ENSMUST00000033979.5 NM_011485 P51557 Q543A5 Q924Y5 Q9D2G1 STAR_MOUSE uc009lhb.1 uc009lhb.2 uc009lhb.3 Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Transporter that binds to and transport cholesterol through the intermembrane space of the mitochondrion. Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747, ChEBI:CHEBI:16113; Evidence=; Steroid metabolism; cholesterol metabolism. May interact with TSPO. Mitochondrion Expressed within glia and neurons in discrete regions of the brain. mitochondrion mitochondrial intermembrane space cytosol organic acid metabolic process steroid biosynthetic process bile acid biosynthetic process estrogen biosynthetic process lipid transport brain development response to nutrient circadian rhythm cholesterol metabolic process glucocorticoid metabolic process lipid binding male gonad development response to herbicide response to toxic substance response to organic substance response to ionizing radiation response to lead ion positive regulation of gene expression response to organic cyclic compound response to activity cholesterol binding diterpenoid metabolic process response to insecticide insecticide metabolic process biphenyl metabolic process dibenzo-p-dioxin metabolic process phenol-containing compound metabolic process phthalate metabolic process mitochondrial crista response to nutrient levels intracellular cholesterol transport cellular response to insulin stimulus response to gonadotropin response to nicotine cellular response to interferon-alpha response to drug response to hydrogen peroxide circadian sleep/wake cycle, REM sleep neuron projection neuronal cell body response to peptide hormone negative regulation of neuron apoptotic process response to estrogen cellular lipid metabolic process response to leptin cellular response to fibroblast growth factor stimulus response to ethanol response to antibiotic regulation of neuronal synaptic plasticity response to steroid hormone positive regulation of neurogenesis regulation of steroid biosynthetic process response to corticosterone response to fungicide testosterone biosynthetic process positive regulation of bile acid biosynthetic process cellular response to lipopolysaccharide cellular response to antibiotic cellular response to metal ion cellular response to cadmium ion cellular response to alkaloid cellular response to cAMP cellular response to glucose stimulus cellular response to interferon-gamma cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus cellular response to luteinizing hormone stimulus cellular response to growth hormone stimulus cellular response to organic cyclic compound cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus cellular response to epinephrine stimulus uc009lhb.1 uc009lhb.2 uc009lhb.3 
ENSMUST00000033983.6 Mak16 ENSMUST00000033983.6 MAK16 homolog (from RefSeq NM_026453.3) ENSMUST00000033983.1 ENSMUST00000033983.2 ENSMUST00000033983.3 ENSMUST00000033983.4 ENSMUST00000033983.5 MAK16_MOUSE NM_026453 Q8BGS0 Q921E0 Q9D5G6 Rbm13 uc009lji.1 uc009lji.2 uc009lji.3 Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGS0-1; Sequence=Displayed; Name=2; IsoId=Q8BGS0-2; Sequence=VSP_014840; [Isoform 2]: May be due to a competing donor splice site. Belongs to the MAK16 family. nucleus nucleolus preribosome, large subunit precursor intracellular membrane-bounded organelle uc009lji.1 uc009lji.2 uc009lji.3 
ENSMUST00000033991.13 Wrn ENSMUST00000033991.13 Werner syndrome RecQ like helicase, transcript variant 1 (from RefSeq NM_011721.4) ENSMUST00000033991.1 ENSMUST00000033991.10 ENSMUST00000033991.11 ENSMUST00000033991.12 ENSMUST00000033991.2 ENSMUST00000033991.3 ENSMUST00000033991.4 ENSMUST00000033991.5 ENSMUST00000033991.6 ENSMUST00000033991.7 ENSMUST00000033991.8 ENSMUST00000033991.9 NM_011721 O09050 O09053 Q80YP9 Q9JKD4 Q9Z241 Q9Z242 WRN_MOUSE uc012gcb.1 uc012gcb.2 uc012gcb.3 Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 magnesium ions per subunit. Has high activity with manganese and zinc ions (in vitro). ; Zinc ions stimulate the exonuclease activity. Monomer, and homooligomer. May exist as homodimer, homotrimer, homotetramer and/or homohexamer. Homotetramer, or homohexamer, when bound to DNA (By similarity). Interacts via its N-terminal domain with WRNIP1 (PubMed:11301316). Interacts with EXO1, PCNA and SUPV3L1. Interacts with PML (isoform PML-4) (By similarity). Interacts (via KBM motif) with XRCC5 and XRCC6; promoting recruitment to DNA damage sites (By similarity). Interacts with RECQL5; this interaction stimulates WRN helicase activity on DNA fork duplexes (By similarity). Nucleus, nucleolus Nucleus Nucleus, nucleoplasm Chromosome Note=Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation. Localizes to DNA damage sites. Expressed ubiquitously in most organs at a low level, highly expressed in testis, ovary and spleen. The KBM 2 (Ku-binding motif 2) and XLM (XLF-like motif) mediate cooperative interaction with XRCC5/Ku80 and XRCC6/Ku70 and recruitment to DNA damage sites. Phosphorylated by PRKDC. Belongs to the helicase family. RecQ subfamily. nucleotide binding magnesium ion binding four-way junction DNA binding Y-form DNA binding bubble DNA binding telomere maintenance double-strand break repair via homologous recombination DNA synthesis involved in DNA repair chromosome, telomeric region replicative cell aging nucleic acid binding DNA binding DNA helicase activity chromatin binding catalytic activity helicase activity nuclease activity exonuclease activity protein binding ATP binding nucleus nucleoplasm replication fork chromosome nucleolus cytoplasm centrosome nucleobase-containing compound metabolic process DNA metabolic process DNA replication DNA unwinding involved in DNA replication DNA repair base-excision repair double-strand break repair DNA recombination cellular response to DNA damage stimulus response to oxidative stress brain development cell aging metabolic process 3'-5' exonuclease activity cellular response to starvation four-way junction helicase activity response to UV-C multicellular organism aging nuclear speck hydrolase activity ATPase activity manganese ion binding replication fork processing MutLalpha complex binding DNA duplex unwinding regulation of growth rate protein homodimerization activity regulation of apoptotic process neuron projection 3'-5' DNA helicase activity cellular metabolic process G-quadruplex DNA unwinding macromolecular complex binding metal ion binding positive regulation of hydrolase activity G-quadruplex DNA binding forked DNA-dependent helicase activity telomeric D-loop disassembly telomeric D-loop binding 3'-flap-structured DNA binding cellular response to gamma radiation nucleic acid phosphodiester bond hydrolysis positive regulation of strand invasion protein localization to nucleolus 8-hydroxy-2'-deoxyguanosine DNA binding uc012gcb.1 uc012gcb.2 uc012gcb.3 
ENSMUST00000033992.9 Gsr ENSMUST00000033992.9 glutathione reductase (from RefSeq NM_010344.4) ENSMUST00000033992.1 ENSMUST00000033992.2 ENSMUST00000033992.3 ENSMUST00000033992.4 ENSMUST00000033992.5 ENSMUST00000033992.6 ENSMUST00000033992.7 ENSMUST00000033992.8 GSHR_MOUSE Gr1 NM_010344 P47791 Q7TNC2 Q8BN97 Q8C9Z6 uc009lkf.1 uc009lkf.2 uc009lkf.3 Maintains high levels of reduced glutathione in the cytosol. Reaction=2 glutathione + NADP(+) = glutathione disulfide + H(+) + NADPH; Xref=Rhea:RHEA:11740, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:58349; EC=1.8.1.7; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Homodimer; disulfide-linked. [Isoform Mitochondrial]: Mitochondrion. [Isoform Cytoplasmic]: Cytoplasm. Event=Alternative initiation; Named isoforms=2; Name=Mitochondrial; IsoId=P47791-1; Sequence=Displayed; Name=Cytoplasmic; IsoId=P47791-2; Sequence=VSP_018973; Each subunit can be divided into 4 domains that are consecutive along the polypeptide chain. Domains 1 and 2 bind FAD and NADPH, respectively. Domain 4 forms the interface. The active site is a redox-active disulfide bond. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. glutathione-disulfide reductase activity cytoplasm mitochondrion cytosol glutathione metabolic process spermatogenesis electron carrier activity external side of plasma membrane oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor electron transport chain cellular response to oxidative stress protein homodimerization activity glutathione binding cell redox homeostasis flavin adenine dinucleotide binding NADP binding oxidation-reduction process cellular oxidant detoxification uc009lkf.1 uc009lkf.2 uc009lkf.3 
ENSMUST00000033999.8 Frg1 ENSMUST00000033999.8 FSHD region gene 1 (from RefSeq NM_013522.3) ENSMUST00000033999.1 ENSMUST00000033999.2 ENSMUST00000033999.3 ENSMUST00000033999.4 ENSMUST00000033999.5 ENSMUST00000033999.6 ENSMUST00000033999.7 Frg1 NM_013522 Q78P92 Q78P92_MOUSE uc012gcs.1 uc012gcs.2 uc012gcs.3 Nucleus, nucleolus Belongs to the FRG1 family. uc012gcs.1 uc012gcs.2 uc012gcs.3 
ENSMUST00000034000.15 Asah1 ENSMUST00000034000.15 N-acylsphingosine amidohydrolase 1 (from RefSeq NM_019734.3) ASAH1_MOUSE Asah Asah1 ENSMUST00000034000.1 ENSMUST00000034000.10 ENSMUST00000034000.11 ENSMUST00000034000.12 ENSMUST00000034000.13 ENSMUST00000034000.14 ENSMUST00000034000.2 ENSMUST00000034000.3 ENSMUST00000034000.4 ENSMUST00000034000.5 ENSMUST00000034000.6 ENSMUST00000034000.7 ENSMUST00000034000.8 ENSMUST00000034000.9 NM_019734 Q9WV54 uc012gcr.1 uc012gcr.2 uc012gcr.3 uc012gcr.4 This gene encodes acid ceramidase, an enzyme that plays a central role in ceramide metabolism. The encoded protein undergoes proteolytic processing to generate a heterodimeric enzyme comprised of alpha and beta subunits that catalyzes the hydrolysis of sphingolipid ceramide into sphingosine and free fatty acid. The homozygous disruption of this gene leads to embryonic lethality in mice whereas the heterozygous animals exhibit a progressive lipid storage disease phenotype. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK152920.1, AK153101.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (PubMed:9653654, PubMed:11829492). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:9653654). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (By similarity). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro- phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (By similarity). Has also an N- acylethanolamine hydrolase activity (By similarity). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (By similarity). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (PubMed:10974027). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (By similarity). Reaction=an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine; Xref=Rhea:RHEA:20856, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868, ChEBI:CHEBI:52639, ChEBI:CHEBI:57756; EC=3.5.1.23; Evidence=; Reaction=H2O + N-dodecanoylsphing-4-enine = dodecanoate + sphing-4- enine; Xref=Rhea:RHEA:41291, ChEBI:CHEBI:15377, ChEBI:CHEBI:18262, ChEBI:CHEBI:57756, ChEBI:CHEBI:72956; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41292; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:41293; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-sphing-4-enine = (9Z)-octadecenoate + sphing-4-enine; Xref=Rhea:RHEA:41299, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57756, ChEBI:CHEBI:77996; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41300; Evidence=; Reaction=H2O + N-tetradecanoylsphing-4-enine = sphing-4-enine + tetradecanoate; Xref=Rhea:RHEA:41287, ChEBI:CHEBI:15377, ChEBI:CHEBI:30807, ChEBI:CHEBI:57756, ChEBI:CHEBI:72957; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:41289; Evidence=; Reaction=H2O + N-hexadecanoylsphing-4-enine = hexadecanoate + sphing-4- enine; Xref=Rhea:RHEA:38891, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:57756, ChEBI:CHEBI:72959; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38892; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38893; Evidence=; Reaction=H2O + N-octadecanoylsphing-4-enine = octadecanoate + sphing-4- enine; Xref=Rhea:RHEA:41279, ChEBI:CHEBI:15377, ChEBI:CHEBI:25629, ChEBI:CHEBI:57756, ChEBI:CHEBI:72961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41280; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:41281; Evidence=; Reaction=H2O + N-dodecanoyl-(4R)-hydroxysphinganine = (4R)- hydroxysphinganine + dodecanoate; Xref=Rhea:RHEA:41303, ChEBI:CHEBI:15377, ChEBI:CHEBI:18262, ChEBI:CHEBI:64124, ChEBI:CHEBI:78001; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:41305; Evidence=; Reaction=H2O + N-(dodecanoyl)-sphinganine = dodecanoate + sphinganine; Xref=Rhea:RHEA:45448, ChEBI:CHEBI:15377, ChEBI:CHEBI:18262, ChEBI:CHEBI:57817, ChEBI:CHEBI:85261; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:45450; Evidence=; Reaction=H2O + N-(acetyl)-sphing-4-enine = acetate + sphing-4-enine; Xref=Rhea:RHEA:58484, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:46979, ChEBI:CHEBI:57756; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58485; Evidence=; Reaction=H2O + N-(hexanoyl)sphing-4-enine = hexanoate + sphing-4-enine; Xref=Rhea:RHEA:41295, ChEBI:CHEBI:15377, ChEBI:CHEBI:17120, ChEBI:CHEBI:57756, ChEBI:CHEBI:63867; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41296; Evidence=; Reaction=H2O + N-octanoylsphing-4-enine = octanoate + sphing-4-enine; Xref=Rhea:RHEA:45092, ChEBI:CHEBI:15377, ChEBI:CHEBI:25646, ChEBI:CHEBI:45815, ChEBI:CHEBI:57756; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45093; Evidence=; Reaction=H2O + N-dodecanoylethanolamine = dodecanoate + ethanolamine; Xref=Rhea:RHEA:45456, ChEBI:CHEBI:15377, ChEBI:CHEBI:18262, ChEBI:CHEBI:57603, ChEBI:CHEBI:85263; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45457; Evidence=; Lipid metabolism; sphingolipid metabolism. Heterodimer; disulfide-linked. The heterodimer is composed of the disulfide-linked alpha and beta chains produced by autocatalytic cleavage of the precursor. Lysosome Secreted Note=Secretion is extremely low and localization to lysosomes is mannose-6-phosphate receptor-dependent. Widely expressed. Expression is detected from 7 dpc to 17 dpc, during fetal development. N-glycosylated. Proteolytically cleaved into two chains alpha and beta that remain associated via a disulfide bond. Cleavage gives rise to a conformation change that activates the enzyme. The same catalytic Cys residue mediates the autoproteolytic cleavage and subsequent hydrolysis of lipid substrates. The beta chain may undergo an additional C-terminal processing. Lethal for homozygous knockout embryos (PubMed:11829492). Heterozygous knockout mice are viable, grow normally and do not present overt clinical phenotype (PubMed:11829492). However, they progressively develop lipid storage-associated phenotypes, with an elevation of ceramides levels and an accumulation of lipid-laden inclusions in liver, more specifically in Kupffer cells, and other tissues (PubMed:11829492). Associated with the accumulation of ceramides, a depression-like phenotype is observed for heterozygous knockout mice (PubMed:23770692). Belongs to the acid ceramidase family. transcription corepressor activity extracellular region extracellular space nucleus lysosome lipid metabolic process sphingolipid metabolic process response to organic substance hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ligand-dependent nuclear receptor binding ceramidase activity keratinocyte differentiation lung development sphingosine biosynthetic process ceramide biosynthetic process ceramide catabolic process regulation of steroid biosynthetic process cellular response to tumor necrosis factor negative regulation of nucleic acid-templated transcription uc012gcr.1 uc012gcr.2 uc012gcr.3 uc012gcr.4 
ENSMUST00000034003.5 Fgl1 ENSMUST00000034003.5 fibrinogen-like protein 1 (from RefSeq NM_145594.2) A0A0R4J0E1 A0A0R4J0E1_MOUSE ENSMUST00000034003.1 ENSMUST00000034003.2 ENSMUST00000034003.3 ENSMUST00000034003.4 Fgl1 NM_145594 uc009lnp.1 uc009lnp.2 uc009lnp.3 Secreted extracellular region hepatocyte proliferation uc009lnp.1 uc009lnp.2 uc009lnp.3 
ENSMUST00000034004.10 Pdgfrl ENSMUST00000034004.10 platelet-derived growth factor receptor-like (from RefSeq NM_026840.3) A0A0R4J0C9 A0A0R4J0C9_MOUSE ENSMUST00000034004.1 ENSMUST00000034004.2 ENSMUST00000034004.3 ENSMUST00000034004.4 ENSMUST00000034004.5 ENSMUST00000034004.6 ENSMUST00000034004.7 ENSMUST00000034004.8 ENSMUST00000034004.9 NM_026840 Pdgfrl uc009lni.1 uc009lni.2 uc009lni.3 uc009lni.4 uc009lni.5 Forms a complex composed of PDGFRL, TNK2 and GRB2. Secreted uc009lni.1 uc009lni.2 uc009lni.3 uc009lni.4 uc009lni.5 
ENSMUST00000034014.14 Fgf20 ENSMUST00000034014.14 fibroblast growth factor 20 (from RefSeq NM_030610.3) ENSMUST00000034014.1 ENSMUST00000034014.10 ENSMUST00000034014.11 ENSMUST00000034014.12 ENSMUST00000034014.13 ENSMUST00000034014.2 ENSMUST00000034014.3 ENSMUST00000034014.4 ENSMUST00000034014.5 ENSMUST00000034014.6 ENSMUST00000034014.7 ENSMUST00000034014.8 ENSMUST00000034014.9 FGF20_MOUSE NM_030610 Q8C7A8 Q9ESL9 uc009lml.1 uc009lml.2 uc009lml.3 Neurotrophic factor that regulates central nervous development and function. Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity). Secreted Belongs to the heparin-binding growth factors family. fibroblast growth factor receptor binding extracellular region growth factor activity positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway cell differentiation negative regulation of neuron apoptotic process regulation of neuron differentiation regulation of cardiac muscle cell proliferation inner ear receptor cell differentiation positive regulation of ERK1 and ERK2 cascade receptor-receptor interaction uc009lml.1 uc009lml.2 uc009lml.3 
ENSMUST00000034015.11 Msmo1 ENSMUST00000034015.11 methylsterol monoxygenase 1 (from RefSeq NM_025436.3) ENSMUST00000034015.1 ENSMUST00000034015.10 ENSMUST00000034015.2 ENSMUST00000034015.3 ENSMUST00000034015.4 ENSMUST00000034015.5 ENSMUST00000034015.6 ENSMUST00000034015.7 ENSMUST00000034015.8 ENSMUST00000034015.9 MSMO1_MOUSE NM_025436 Q543V8 Q9CRA4 Sc4mol uc009lux.1 uc009lux.2 uc009lux.3 Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol. Reaction=4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)- [cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha- cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O; Xref=Rhea:RHEA:55220, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16455, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:58387; EC=1.14.18.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55221; Evidence=; Reaction=4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)- [cytochrome b5] + 5 H(+) + 3 O2 = 4beta-methylzymosterol-4alpha- carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O; Xref=Rhea:RHEA:55244, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18364, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:64925; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55245; Evidence=; Reaction=4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O; Xref=Rhea:RHEA:47056, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:1949, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:143575; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47057; Evidence=; Reaction=4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)- [cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-7-en- 3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O; Xref=Rhea:RHEA:62768, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:145943; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62769; Evidence=; Reaction=4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)- [cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha- cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O; Xref=Rhea:RHEA:62776, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:87044, ChEBI:CHEBI:87047; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62777; Evidence=; Reaction=4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)- [cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-8- ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O; Xref=Rhea:RHEA:62780, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:87051, ChEBI:CHEBI:87055; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62781; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 3/6. Steroid biosynthesis; cholesterol biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein The histidine box domains may contain the active site and/or be involved in metal ion binding. Belongs to the sterol desaturase family. C-4 methylsterol oxidase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process steroid metabolic process lipid biosynthetic process membrane integral component of membrane sterol biosynthetic process oxidoreductase activity oxidation-reduction process uc009lux.1 uc009lux.2 uc009lux.3 
ENSMUST00000034017.9 Klhl2 ENSMUST00000034017.9 kelch-like 2, Mayven (from RefSeq NM_178633.3) ENSMUST00000034017.1 ENSMUST00000034017.2 ENSMUST00000034017.3 ENSMUST00000034017.4 ENSMUST00000034017.5 ENSMUST00000034017.6 ENSMUST00000034017.7 ENSMUST00000034017.8 KLHL2_MOUSE Klhl2 NM_178633 Q8CCU0 Q8JZP3 Q8R3U4 uc057alr.1 uc057alr.2 uc057alr.3 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation (PubMed:21549840). The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (PubMed:21549840). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (By similarity). Plays a role in the reorganization of the actin cytoskeleton (By similarity). Promotes growth of cell projections in oligodendrocyte precursors (By similarity). Protein modification; protein ubiquitination. Component of the BCR(KLHL2) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL2 and RBX1 (PubMed:21549840). Binds actin. Interacts with KLHL12 (By similarity). Interacts (via N- terminus) with FYN (via SH3 domain) (By similarity). Cytoplasm, cytoskeleton Cell projection, ruffle Cell projection Cell projection, lamellipodium Cytoplasm, cytosol Note=A proportion colocalizes with the actin cytoskeleton (By similarity). When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (PubMed:21549840). Sequence=BAC27712.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; stress fiber ruffle actin binding cytoplasm cytosol cytoskeleton actin cytoskeleton protein ubiquitination lamellipodium Cul3-RING ubiquitin ligase complex identical protein binding protein homodimerization activity cell projection uc057alr.1 uc057alr.2 uc057alr.3 
ENSMUST00000034021.12 Galnt7 ENSMUST00000034021.12 polypeptide N-acetylgalactosaminyltransferase 7, transcript variant 1 (from RefSeq NM_144731.4) ENSMUST00000034021.1 ENSMUST00000034021.10 ENSMUST00000034021.11 ENSMUST00000034021.2 ENSMUST00000034021.3 ENSMUST00000034021.4 ENSMUST00000034021.5 ENSMUST00000034021.6 ENSMUST00000034021.7 ENSMUST00000034021.8 ENSMUST00000034021.9 GALT7_MOUSE NM_144731 Q80VA0 Q8BY62 Q8BZ70 Q8BZW0 Q91VW6 Q99MD7 uc009lsy.1 uc009lsy.2 uc009lsy.3 uc009lsy.4 Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D- galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified (By similarity). Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Evidence=; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80VA0-1; Sequence=Displayed; Name=2; IsoId=Q80VA0-2; Sequence=VSP_011204; Name=3; IsoId=Q80VA0-3; Sequence=VSP_011204, VSP_011205; Highly expressed in sublingual gland. Expressed at lower level in stomach, small intestiine and colon. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Sequence=AAH07484.1; Type=Erroneous initiation; Evidence=; Name=Functional Glycomics Gateway - GTase; Note=N- acetylgalactosaminyltransferase 7; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_516"; Golgi membrane polypeptide N-acetylgalactosaminyltransferase activity Golgi apparatus protein glycosylation protein O-linked glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups carbohydrate binding metal ion binding uc009lsy.1 uc009lsy.2 uc009lsy.3 uc009lsy.4 
ENSMUST00000034022.4 Sap30 ENSMUST00000034022.4 sin3 associated polypeptide (from RefSeq NM_021788.3) A2RSE9 ENSMUST00000034022.1 ENSMUST00000034022.2 ENSMUST00000034022.3 NM_021788 O88574 Q99JB9 SAP30_MOUSE Sap30 uc009lsu.1 uc009lsu.2 uc009lsu.3 uc009lsu.4 Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. Component of the histone deacetylase complex that includes at least SIN3A, HDAC1 and HDAC2 (PubMed:9702189). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (PubMed:28554894). Interacts with HDAC1 (PubMed:9702189). Interacts with SIN3A, SIN3B, HDAC2, RBBP4 and NCOR1 (PubMed:9702189). Interacts directly with SAMSN1 (PubMed:20478393). Interacts with HCFC1 (By similarity). Interacts with SAP30BP (By similarity). O88574; Q60974: Ncor1; NbExp=3; IntAct=EBI-593511, EBI-349004; O88574; Q60520: Sin3a; NbExp=6; IntAct=EBI-593511, EBI-349034; Nucleus. Belongs to the SAP30 family. histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter DNA binding transcription corepressor activity histone deacetylase activity protein binding nucleus nucleoplasm regulation of transcription, DNA-templated histone deacetylation Sin3 complex skeletal muscle cell differentiation metal ion binding uc009lsu.1 uc009lsu.2 uc009lsu.3 uc009lsu.4 
ENSMUST00000034023.4 Scrg1 ENSMUST00000034023.4 scrapie responsive gene 1, transcript variant 1 (from RefSeq NM_009136.4) ENSMUST00000034023.1 ENSMUST00000034023.2 ENSMUST00000034023.3 NM_009136 Q543T5 Q543T5_MOUSE Scrg1 uc009lst.1 uc009lst.2 mesenchymal stem cell proliferation uc009lst.1 uc009lst.2 
ENSMUST00000034026.10 Hpgd ENSMUST00000034026.10 hydroxyprostaglandin dehydrogenase 15 (NAD) (from RefSeq NM_008278.2) ENSMUST00000034026.1 ENSMUST00000034026.2 ENSMUST00000034026.3 ENSMUST00000034026.4 ENSMUST00000034026.5 ENSMUST00000034026.6 ENSMUST00000034026.7 ENSMUST00000034026.8 ENSMUST00000034026.9 NM_008278 PGDH_MOUSE Pgdh1 Q61106 Q8VCC1 uc009lso.1 uc009lso.2 uc009lso.3 Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (By similarity) (PubMed:8950170). Decreases the levels of the pro- proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity- induced adipose inflammation (By similarity). Reaction=NAD(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADH; Xref=Rhea:RHEA:11876, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:606564; EC=1.1.1.141; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11877; Evidence=; Reaction=(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15- oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:23260, ChEBI:CHEBI:15378, ChEBI:CHEBI:57409, ChEBI:CHEBI:57410, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.232; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23261; Evidence=; Reaction=(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11- oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:48640, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78836, ChEBI:CHEBI:90697; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48641; Evidence=; Reaction=lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy- (7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:41572, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:67026, ChEBI:CHEBI:78311; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41573; Evidence=; Reaction=15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+); Xref=Rhea:RHEA:41596, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78325, ChEBI:CHEBI:78329; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41597; Evidence=; Reaction=NAD(+) + prostaglandin A1 = 15-oxo-prostaglandin A1 + H(+) + NADH; Xref=Rhea:RHEA:41263, ChEBI:CHEBI:15378, ChEBI:CHEBI:57398, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:85072; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41264; Evidence=; Reaction=NAD(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADH; Xref=Rhea:RHEA:16477, ChEBI:CHEBI:15378, ChEBI:CHEBI:57397, ChEBI:CHEBI:57401, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16478; Evidence=; Reaction=14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH; Xref=Rhea:RHEA:48952, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90866, ChEBI:CHEBI:90867; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48953; Evidence=; Reaction=NAD(+) + resolvin E1 = 18-oxo-resolvin E1 + H(+) + NADH; Xref=Rhea:RHEA:49244, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:91000, ChEBI:CHEBI:91001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49245; Evidence=; Reaction=NAD(+) + resolvin D1 = 8-oxoresolvin D1 + H(+) + NADH; Xref=Rhea:RHEA:50124, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132079, ChEBI:CHEBI:132080; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50125; Evidence=; Reaction=NAD(+) + resolvin D1 = 17-oxoresolvin D1 + H(+) + NADH; Xref=Rhea:RHEA:50128, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132079, ChEBI:CHEBI:132081; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50129; Evidence=; Reaction=NAD(+) + resolvin D2 = 7-oxoresolvin D2 + H(+) + NADH; Xref=Rhea:RHEA:53584, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:133367, ChEBI:CHEBI:137497; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53585; Evidence=; Reaction=NAD(+) + resolvin D2 = 16-oxoresolvin D2 + H(+) + NADH; Xref=Rhea:RHEA:53588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:133367, ChEBI:CHEBI:137498; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53589; Evidence=; Homodimer. Cytoplasm Expressed in proximal convoluted tubules of the kidney, where it colocalizes with the prostaglandin transporter SLC22A22 (at protein level) (PubMed:20448048). Expressed in lung, intestine, stomach and liver (PubMed:8950170). Belongs to the short-chain dehydrogenases/reductases (SDR) family. Sequence=AAB41825.1; Type=Frameshift; Evidence=; kidney development catalytic activity prostaglandin E receptor activity extracellular space nucleoplasm cytoplasm cytosol lipid metabolic process fatty acid metabolic process prostaglandin metabolic process transforming growth factor beta receptor signaling pathway female pregnancy parturition basolateral plasma membrane 15-hydroxyprostaglandin dehydrogenase (NAD+) activity oxidoreductase activity ovulation response to estradiol response to lipopolysaccharide protein homodimerization activity positive regulation of apoptotic process response to ethanol negative regulation of cell cycle NAD binding oxidation-reduction process NAD+ binding thrombin-activated receptor signaling pathway ductus arteriosus closure positive regulation of vascular smooth muscle cell proliferation uc009lso.1 uc009lso.2 uc009lso.3 
ENSMUST00000034029.8 Ednra ENSMUST00000034029.8 endothelin receptor type A (from RefSeq NM_010332.2) EDNRA_MOUSE ENSMUST00000034029.1 ENSMUST00000034029.2 ENSMUST00000034029.3 ENSMUST00000034029.4 ENSMUST00000034029.5 ENSMUST00000034029.6 ENSMUST00000034029.7 Ednra Gpcr10 NM_010332 O54993 Q61614 Q91VV2 uc009mhv.1 uc009mhv.2 uc009mhv.3 Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). Interacts with HDAC7 and KAT5. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily. branching involved in blood vessel morphogenesis response to hypoxia in utero embryonic development histamine secretion positive regulation of protein phosphorylation glomerular filtration G-protein coupled receptor activity endothelin receptor activity protein binding plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration protein kinase C-activating G-protein coupled receptor signaling pathway Rho protein signal transduction heart development respiratory gaseous exchange regulation of blood pressure positive regulation of cell proliferation regulation of glucose transport neural crest cell development artery smooth muscle contraction membrane integral component of membrane peptidyl-tyrosine phosphorylation sensory perception of pain T-tubule nuclear membrane response to lipopolysaccharide vasoconstriction positive regulation of odontogenesis negative regulation of apoptotic process penile erection response to morphine fibroblast proliferation enteric nervous system development smooth muscle cell proliferation regulation of epithelial cell proliferation positive regulation of inflammatory response positive regulation of release of sequestered calcium ion into cytosol positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway positive regulation of calcium ion transport head development positive regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus endothelin receptor signaling pathway positive regulation of neutrophil chemotaxis positive regulation of kidney development membrane raft protein tyrosine kinase activity uc009mhv.1 uc009mhv.2 uc009mhv.3 
ENSMUST00000034030.15 Tmem184c ENSMUST00000034030.15 transmembrane protein 184C, transcript variant 1 (from RefSeq NM_145599.4) ENSMUST00000034030.1 ENSMUST00000034030.10 ENSMUST00000034030.11 ENSMUST00000034030.12 ENSMUST00000034030.13 ENSMUST00000034030.14 ENSMUST00000034030.2 ENSMUST00000034030.3 ENSMUST00000034030.4 ENSMUST00000034030.5 ENSMUST00000034030.6 ENSMUST00000034030.7 ENSMUST00000034030.8 ENSMUST00000034030.9 NM_145599 Q3TPR7 Q8CCD2 Q99KQ7 T184C_MOUSE Tmem34 uc009mhr.1 uc009mhr.2 uc009mhr.3 uc009mhr.4 uc009mhr.5 Possible tumor suppressor which may play a role in cell growth. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TPR7-1; Sequence=Displayed; Name=2; IsoId=Q3TPR7-2; Sequence=VSP_025567; Belongs to the TMEM184 family. membrane integral component of membrane uc009mhr.1 uc009mhr.2 uc009mhr.3 uc009mhr.4 uc009mhr.5 
ENSMUST00000034033.15 Iqcm ENSMUST00000034033.15 IQ motif containing M, transcript variant 2 (from RefSeq NM_027944.1) 1700007B14Rik ENSMUST00000034033.1 ENSMUST00000034033.10 ENSMUST00000034033.11 ENSMUST00000034033.12 ENSMUST00000034033.13 ENSMUST00000034033.14 ENSMUST00000034033.2 ENSMUST00000034033.3 ENSMUST00000034033.4 ENSMUST00000034033.5 ENSMUST00000034033.6 ENSMUST00000034033.7 ENSMUST00000034033.8 ENSMUST00000034033.9 Iqcm NM_027944 Q149I8 Q149I8_MOUSE uc009mhj.1 uc009mhj.2 uc009mhj.3 uc009mhj.4 uc009mhj.5 molecular_function cellular_component biological_process uc009mhj.1 uc009mhj.2 uc009mhj.3 uc009mhj.4 uc009mhj.5 
ENSMUST00000034034.10 Isx ENSMUST00000034034.10 intestine specific homeobox, transcript variant 2 (from RefSeq NM_027837.4) B1Q2M1 B1Q2M1_MOUSE ENSMUST00000034034.1 ENSMUST00000034034.2 ENSMUST00000034034.3 ENSMUST00000034034.4 ENSMUST00000034034.5 ENSMUST00000034034.6 ENSMUST00000034034.7 ENSMUST00000034034.8 ENSMUST00000034034.9 Isx NM_027837 Pix-1 uc009mgv.1 uc009mgv.2 uc009mgv.3 Nucleus DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc009mgv.1 uc009mgv.2 uc009mgv.3 
ENSMUST00000034041.9 Irf2 ENSMUST00000034041.9 interferon regulatory factor 2, transcript variant 1 (from RefSeq NM_008391.4) ENSMUST00000034041.1 ENSMUST00000034041.2 ENSMUST00000034041.3 ENSMUST00000034041.4 ENSMUST00000034041.5 ENSMUST00000034041.6 ENSMUST00000034041.7 ENSMUST00000034041.8 Irf2 NM_008391 Q3U2Z2 Q3U2Z2_MOUSE uc009lqo.1 uc009lqo.2 uc009lqo.3 uc009lqo.4 Nucleus Belongs to the IRF family. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol focal adhesion regulation of transcription, DNA-templated cell proliferation transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter defense response to virus uc009lqo.1 uc009lqo.2 uc009lqo.3 uc009lqo.4 
ENSMUST00000034045.15 Cenpu ENSMUST00000034045.15 centromere protein U, transcript variant 1 (from RefSeq NM_027973.4) CENPU_MOUSE ENSMUST00000034045.1 ENSMUST00000034045.10 ENSMUST00000034045.11 ENSMUST00000034045.12 ENSMUST00000034045.13 ENSMUST00000034045.14 ENSMUST00000034045.2 ENSMUST00000034045.3 ENSMUST00000034045.4 ENSMUST00000034045.5 ENSMUST00000034045.6 ENSMUST00000034045.7 ENSMUST00000034045.8 ENSMUST00000034045.9 Mlf1ip NM_027973 Q6UNA2 Q8C4M7 Q9D9U1 uc009lqg.1 uc009lqg.2 uc009lqg.3 Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity). Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts with MLF1 (By similarity). Cytoplasm Nucleus Chromosome, centromere, kinetochore Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates (By similarity). Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q8C4M7-1; Sequence=Displayed; Name=2; IsoId=Q8C4M7-2; Sequence=VSP_020031, VSP_020032; Testis, spleen, heart, kidney, liver, lung, brain and CFU-E erythroid precursor cells. Expressed at different stages of development between 7 dpc and 17 dpc, and highest expression seen at 11 dpc. Detected in the liver at 13.5 dpc and strongly expressed in the cephalic mesenchyme and roof of the hindbrain, lining of the pericardial cavity and atrial chamber of the heart and lumen of the stomach in 11.5-day embryos. Phosphorylated by PLK1 at Thr-74, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1. Belongs to the CENP-U/AME1 family. chromosome, centromeric region kinetochore condensed chromosome kinetochore protein binding nucleus chromosome cytoplasm microtubule organizing center chordate embryonic development uc009lqg.1 uc009lqg.2 uc009lqg.3 
ENSMUST00000034046.13 Acsl1 ENSMUST00000034046.13 acyl-CoA synthetase long-chain family member 1, transcript variant 2 (from RefSeq NM_007981.5) ACSL1_MOUSE Acsl1 Acsl2 ENSMUST00000034046.1 ENSMUST00000034046.10 ENSMUST00000034046.11 ENSMUST00000034046.12 ENSMUST00000034046.2 ENSMUST00000034046.3 ENSMUST00000034046.4 ENSMUST00000034046.5 ENSMUST00000034046.6 ENSMUST00000034046.7 ENSMUST00000034046.8 ENSMUST00000034046.9 Facl2 NM_007981 P41216 Q6GTG6 Q9DBK5 uc009lqe.1 uc009lqe.2 uc009lqe.3 The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Preferentially uses palmitoleate, oleate and linoleate (By similarity). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs). Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl- CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:456215; EC=6.2.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19714; Evidence=; Reaction=3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA; Xref=Rhea:RHEA:21380, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:37257, ChEBI:CHEBI:57287, ChEBI:CHEBI:57391, ChEBI:CHEBI:456215; EC=6.2.1.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21381; Evidence=; Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl- CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30752; Evidence=; Reaction=(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:36139, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61526, ChEBI:CHEBI:72745, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36140; Evidence=; Reaction=2,6,10,14-tetramethylpentadecanoate + ATP + CoA = AMP + diphosphate + pristanoyl-CoA; Xref=Rhea:RHEA:47264, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:77250, ChEBI:CHEBI:77268, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47265; Evidence=; Reaction=14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15- epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52016, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:84024, ChEBI:CHEBI:136117, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52017; Evidence=; Reaction=5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5- hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52108, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65341, ChEBI:CHEBI:136407, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52109; Evidence=; Reaction=12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12- hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52112, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:90718, ChEBI:CHEBI:136408, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52113; Evidence=; Reaction=15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15- hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52116, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:78832, ChEBI:CHEBI:136409, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52117; Evidence=; Reaction=(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:33607, ChEBI:CHEBI:30616, ChEBI:CHEBI:30823, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33608; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Inhibited at high temperature and by arachidonate. Mitochondrion outer membrane ; Single-pass type III membrane protein Peroxisome membrane ; Single-pass type III membrane protein Microsome membrane ; Single-pass type III membrane protein Endoplasmic reticulum membrane ; Single-pass type III membrane protein Belongs to the ATP-dependent AMP-binding enzyme family. very long-chain fatty acid metabolic process nucleotide binding long-chain fatty acid metabolic process catalytic activity acyl-CoA ligase activity long-chain fatty acid-CoA ligase activity ATP binding mitochondrion mitochondrial outer membrane peroxisome peroxisomal membrane endoplasmic reticulum endoplasmic reticulum membrane plasma membrane lipid metabolic process fatty acid metabolic process response to nutrient lipid biosynthetic process response to organic substance response to organic cyclic compound fatty acid transport membrane integral component of membrane ligase activity triglyceride biosynthetic process organelle membrane adiponectin-activated signaling pathway response to oleic acid long-chain fatty-acyl-CoA biosynthetic process xenobiotic catabolic process response to drug intracellular membrane-bounded organelle long-chain fatty acid import arachidonate-CoA ligase activity phytanate-CoA ligase activity positive regulation of protein serine/threonine kinase activity decanoate--CoA ligase activity uc009lqe.1 uc009lqe.2 uc009lqe.3 
ENSMUST00000034048.13 Cfap97 ENSMUST00000034048.13 cilia and flagella associated protein 97, transcript variant 1 (from RefSeq NM_025747.4) CFA97_MOUSE Cfap97 ENSMUST00000034048.1 ENSMUST00000034048.10 ENSMUST00000034048.11 ENSMUST00000034048.12 ENSMUST00000034048.2 ENSMUST00000034048.3 ENSMUST00000034048.4 ENSMUST00000034048.5 ENSMUST00000034048.6 ENSMUST00000034048.7 ENSMUST00000034048.8 ENSMUST00000034048.9 Kiaa1430 NM_025747 Q6ZPR1 Q9D462 uc009lpw.1 uc009lpw.2 uc009lpw.3 Highly expressed in testis with lower levels detected in other tissues including lung, heart and kidney. Belongs to the CFAP97 family. Sequence=BAC98168.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc009lpw.1 uc009lpw.2 uc009lpw.3 
ENSMUST00000034049.5 Slc25a4 ENSMUST00000034049.5 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 (from RefSeq NM_007450.5) ADT1_MOUSE Aac1 Anc1 Ant1 ENSMUST00000034049.1 ENSMUST00000034049.2 ENSMUST00000034049.3 ENSMUST00000034049.4 NM_007450 P48962 Q62164 Slc25a4 uc009lpz.1 uc009lpz.2 uc009lpz.3 uc009lpz.4 uc009lpz.5 ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:31618756, PubMed:31341297). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate- binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31489369, PubMed:31341297). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (PubMed:31341297). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (PubMed:31341297). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (PubMed:31341297). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (PubMed:31341297). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31489369). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (PubMed:31489369). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (PubMed:31618756). Reaction=ADP(in) + ATP(out) = ADP(out) + ATP(in); Xref=Rhea:RHEA:34999, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; Evidence=; Reaction=H(+)(in) = H(+)(out); Xref=Rhea:RHEA:34979, ChEBI:CHEBI:15378; Evidence=; The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA) (By similarity). The cytoplasmic-open state (c-state) is inhibited by the membrane- impermeable toxic inhibitor carboxyatractyloside (CATR) (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity (PubMed:31341297). Monomer (By similarity). Found in a complex with ARL2, ARL2BP and SLC25A4/ANT1 (PubMed:11809823). Interacts with ARL2BP (PubMed:11809823). Interacts with TIMM44; leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (PubMed:31618756). Mitochondrion inner membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Note=The complex formed with ARL2BP, ARL2 and SLC25A4/ANT1 is expressed in mitochondria (PubMed:11809823). May localize to non-mitochondrial membranes (By similarity). Highly expressed in heart, skeletal muscle and brain. The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue. Under cell death induction, transglutaminated by TGM2 (PubMed:19644512). Transglutamination leads to formation of covalent cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming polymers (PubMed:19644512). Mice display mitochondrial myopathy affecting heart and skeletal muscles (PubMed:9207786). Hindlimb muscles exhibit abundant ragged-red fibers, characteristic of mitochondrial myopathies (PubMed:9207786). Increased mitochondrial activity is observed, reflecting greater mitochondrial content (PubMed:9207786). In addition, mice are exercise intolerant (PubMed:9207786). Mice develop chronic progressive external ophthalmoplegia, but show normal ocular motility (PubMed:16303948). In retina, while abnormalities are observed in extraocular muscles, retinal structure and function are not affected normal (PubMed:20671283). Cells display impaired mitochondrial uncoupling (PubMed:31341297). Cells show impaired autophagy, leading to accumulation of aberrant mitochondria (PubMed:31618756). Mice lacking Slc25a4/Ant1 and Slc25a5/Ant2 in liver still have mitochondrial permeability transition pore (mPTP) activity, although more Ca(2+) is required to activate the mPTP (PubMed:14749836). Deletion of Slc25a4/Ant1, Slc25a5/Ant2 and Slc25a31/Ant4 in liver completely inhibits mPTP (PubMed:31489369). Mice lacking Slc25a4/Ant1, Slc25a5/Ant2, Slc25a31/Ant4 and Ppif lack Ca(2+)-induced mPTP formation (PubMed:31489369). Belongs to the mitochondrial carrier (TC 2.A.29) family. Was reported as a homodimer (PubMed:11809823). However, 3D structure data show that it forms a monomer (By similarity). It is unclear if SLC25A4/ANT1 constitutes a pore-forming component of mitochondrial permeability transition pore (mPTP) (PubMed:14749836, PubMed:31489369). Initial reports, based on deletion of Slc25a4/Ant1 and Slc25a5/Ant2, suggested that ADP/ATP translocase rather acts as a regulator of mPTP (PubMed:14749836). However, deletion of all ADP/ATP translocase components (Slc25a4/Ant1, Slc25a5/Ant2 and Slc25a31/Ant4) completely inhibits mPTP, suggesting that ADP/ATP translocase constitutes a pore-forming component of mPTP (PubMed:31489369). Discrepancy between reports may be caused by overexpression of Slc25a31/Ant4 in mice lacking Slc25a4/Ant1 and Slc25a5/Ant2, which compensates for the loss of Slc25a4/Ant1 and Slc25a5/Ant2 (PubMed:31489369). ATP:ADP antiporter activity protein binding mitochondrion mitochondrial outer membrane mitochondrial inner membrane apoptotic mitochondrial changes negative regulation of cardiac muscle cell apoptotic process ADP transport ATP transport membrane integral component of membrane enzyme binding transmembrane transporter activity integral component of mitochondrial membrane myelin sheath membrane raft transmembrane transport negative regulation of necroptotic process positive regulation of cell growth involved in cardiac muscle cell development negative regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of oxidative phosphorylation uncoupler activity uc009lpz.1 uc009lpz.2 uc009lpz.3 uc009lpz.4 uc009lpz.5 
ENSMUST00000034051.7 Ufsp2 ENSMUST00000034051.7 UFM1-specific peptidase 2 (from RefSeq NM_138668.2) ENSMUST00000034051.1 ENSMUST00000034051.2 ENSMUST00000034051.3 ENSMUST00000034051.4 ENSMUST00000034051.5 ENSMUST00000034051.6 NM_138668 Q8C5I0 Q99K23 UFSP2_MOUSE Ufsp2 uc009lpp.1 uc009lpp.2 uc009lpp.3 uc009lpp.4 Thiol-dependent isopeptidase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (PubMed:17182609, PubMed:21228277). Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (By similarity). Interacts with DDRGK1 (PubMed:21228277). Interacts with TRIP4; deufmylates TRIP4 (By similarity). Cytoplasm Endoplasmic reticulum Nucleus Expressed at high level in brain, kidney, stomach, skeletal muscle, liver, pancreas, spleen and testis. Belongs to the peptidase C78 family. Sequence=BAC37214.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; nucleus cytoplasm endoplasmic reticulum proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity thiolester hydrolase activity regulation of intracellular estrogen receptor signaling pathway UFM1 hydrolase activity uc009lpp.1 uc009lpp.2 uc009lpp.3 uc009lpp.4 
ENSMUST00000034052.14 Anxa10 ENSMUST00000034052.14 annexin A10, transcript variant 1 (from RefSeq NM_001136089.2) ANX10_MOUSE ENSMUST00000034052.1 ENSMUST00000034052.10 ENSMUST00000034052.11 ENSMUST00000034052.12 ENSMUST00000034052.13 ENSMUST00000034052.2 ENSMUST00000034052.3 ENSMUST00000034052.4 ENSMUST00000034052.5 ENSMUST00000034052.6 ENSMUST00000034052.7 ENSMUST00000034052.8 ENSMUST00000034052.9 NM_001136089 Q3TGJ1 Q9QZ10 uc009lup.1 uc009lup.2 uc009lup.3 uc009lup.4 Belongs to the annexin family. calcium ion binding calcium-dependent phospholipid binding mitochondrion uc009lup.1 uc009lup.2 uc009lup.3 uc009lup.4 
ENSMUST00000034053.7 Pdlim3 ENSMUST00000034053.7 PDZ and LIM domain 3, transcript variant 2 (from RefSeq NM_016798.5) ENSMUST00000034053.1 ENSMUST00000034053.2 ENSMUST00000034053.3 ENSMUST00000034053.4 ENSMUST00000034053.5 ENSMUST00000034053.6 NM_016798 O70209 PDLI3_MOUSE uc009lpl.1 uc009lpl.2 uc009lpl.3 May play a role in the organization of actin filament arrays within muscle cells. Interacts with ACTN2 (By similarity). Forms a heterodimer with PDLIM4 (via LIM domain) (PubMed:15663004). Cytoplasm, myofibril, sarcomere, Z line Note=Localizes to myofiber Z-lines. At 15 dpc highly expressed in skeletal muscle and heart. stress fiber actin binding protein binding cytoplasm cell-cell adherens junction actin filament organization heart development cytoskeletal protein binding structural constituent of muscle actin cytoskeleton Z disc actin cytoskeleton organization filamentous actin metal ion binding muscle alpha-actinin binding muscle structure development uc009lpl.1 uc009lpl.2 uc009lpl.3 
ENSMUST00000034056.12 Tlr3 ENSMUST00000034056.12 toll-like receptor 3, transcript variant 1 (from RefSeq NM_126166.5) ENSMUST00000034056.1 ENSMUST00000034056.10 ENSMUST00000034056.11 ENSMUST00000034056.2 ENSMUST00000034056.3 ENSMUST00000034056.4 ENSMUST00000034056.5 ENSMUST00000034056.6 ENSMUST00000034056.7 ENSMUST00000034056.8 ENSMUST00000034056.9 NM_126166 Q91ZM4 Q99MB1 TLR3_MOUSE Tlr3 uc009loz.1 uc009loz.2 uc009loz.3 Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity). Monomer and homodimer; dimerization is triggered by ligand- binding, the signaling unit is composed of one ds-RNA of around 40 bp and two TLR3 molecules, and lateral clustering of signaling units along the length of the ds-RNA ligand is required for TLR3 signal transduction. Interacts (via transmembrane domain) with UNC93B1; the interaction is required for transport from the ER to the endosomes (PubMed:33432245). Interacts with SRC; upon binding of double-stranded RNA (By similarity). Interacts with TICAM1 (via the TIR domain) in response to poly(I:C) and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436). The tyrosine-phosphorylated form (via TIR domain) interacts with WDFY1 (via WD repeat 2) in response to poly(I:C) (PubMed:25736436). Ubiquitinated by RNF170 at Lys-766 via 'Lys-48'- linked ubiquitin chains; leading to TLR3 proteasomal degradation (PubMed:31076723). Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane Early endosome Highly expressed in lung. After intraperitoneal injection of lipopolysaccharide, highly expressed in brain, heart, kidney, liver, lung and spleen. ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18. TLR3 signaling requires a proteolytic cleavage mediated by cathepsins CTSB and CTSH, the cleavage occurs between amino acids 252 and 346. The cleaved form of TLR3 is the predominant form found in endosomes (By similarity). Ubiquitinated by TRIM3; leading to recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes. Ubiquitinated by ZNRF1 via 'Lys-63'-linked ubiquitin chains; leading to TLR3 lysosomal trafficking and degradation. Belongs to the Toll-like receptor family. microglial cell activation positive regulation of cytokine production toll-like receptor signaling pathway immune system process regulation of dendritic cell cytokine production MyD88-independent toll-like receptor signaling pathway RNA binding double-stranded RNA binding transmembrane signaling receptor activity protein binding cytoplasm endosome early endosome endoplasmic reticulum endoplasmic reticulum membrane integral component of plasma membrane defense response inflammatory response signal transduction I-kappaB phosphorylation male gonad development response to virus cell surface endosome membrane positive regulation of gene expression membrane integral component of membrane positive regulation of type I interferon production positive regulation of chemokine production positive regulation of interferon-beta production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of toll-like receptor signaling pathway toll-like receptor 3 signaling pathway positive regulation of type III interferon production cellular response to interferon-beta cellular response to drug identical protein binding positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA response to dsRNA positive regulation of interferon-gamma biosynthetic process positive regulation of chemokine biosynthetic process innate immune response positive regulation of interferon-alpha biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of inflammatory response positive regulation of NF-kappaB transcription factor activity defense response to virus cellular response to mechanical stimulus cellular response to interferon-gamma cellular response to exogenous dsRNA extrinsic apoptotic signaling pathway necroptotic signaling pathway positive regulation of NIK/NF-kappaB signaling uc009loz.1 uc009loz.2 uc009loz.3 
ENSMUST00000034058.14 Cbr4 ENSMUST00000034058.14 carbonyl reductase 4 (from RefSeq NM_145595.2) CBR4_MOUSE ENSMUST00000034058.1 ENSMUST00000034058.10 ENSMUST00000034058.11 ENSMUST00000034058.12 ENSMUST00000034058.13 ENSMUST00000034058.2 ENSMUST00000034058.3 ENSMUST00000034058.4 ENSMUST00000034058.5 ENSMUST00000034058.6 ENSMUST00000034058.7 ENSMUST00000034058.8 ENSMUST00000034058.9 NM_145595 Q3UBY4 Q8BXV1 Q91VT4 uc009lub.1 uc009lub.2 uc009lub.3 uc009lub.4 Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)- hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o- quinones and p-quinones (in vitro). Reaction=a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH; Xref=Rhea:RHEA:17397, Rhea:RHEA-COMP:9916, Rhea:RHEA- COMP:9945, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78776, ChEBI:CHEBI:78827; EC=1.1.1.100; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17399; Evidence=; Reaction=a quinone + H(+) + NADPH = a quinol + NADP(+); Xref=Rhea:RHEA:46164, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132124; EC=1.6.5.10; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46165; Evidence=; Lipid metabolism; fatty acid biosynthesis. Homotetramer (in vitro). Heterotetramer with HSD17B8; contains two molecules each of HSD17B8 and CBR4. Does not form homotetramers when HSD17B8 is coexpressed, only heterotetramers (in vitro). Mitochondrion matrix Belongs to the short-chain dehydrogenases/reductases (SDR) family. Sequence=BAC31519.1; Type=Erroneous initiation; Evidence=; NAD(P)H dehydrogenase (quinone) activity mitochondrion mitochondrial matrix lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process NADPH dehydrogenase (quinone) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor daunorubicin metabolic process doxorubicin metabolic process 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity quinone binding protein homotetramerization protein heterotetramerization oxidation-reduction process NADPH binding oxidoreductase complex uc009lub.1 uc009lub.2 uc009lub.3 uc009lub.4 
ENSMUST00000034060.7 Sh3rf1 ENSMUST00000034060.7 SH3 domain containing ring finger 1 (from RefSeq NM_021506.3) E9QQ33 E9QQ33_MOUSE ENSMUST00000034060.1 ENSMUST00000034060.2 ENSMUST00000034060.3 ENSMUST00000034060.4 ENSMUST00000034060.5 ENSMUST00000034060.6 NM_021506 Sh3rf1 uc009ltx.1 uc009ltx.2 uc009ltx.3 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Cell projection, lamellipodium Cytoplasm, perinuclear region Golgi apparatus, trans-Golgi network Belongs to the SH3RF family. cytosol apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of JNK cascade metal ion binding protein autoubiquitination ubiquitin protein ligase activity negative regulation of extrinsic apoptotic signaling pathway uc009ltx.1 uc009ltx.2 uc009ltx.3 
ENSMUST00000034064.5 F11 ENSMUST00000034064.5 coagulation factor XI, transcript variant 1 (from RefSeq NM_028066.3) ENSMUST00000034064.1 ENSMUST00000034064.2 ENSMUST00000034064.3 ENSMUST00000034064.4 FA11_MOUSE NM_028066 Q91Y47 Q9DAT3 uc009los.1 uc009los.2 uc009los.3 uc009los.4 This gene encodes a glycoprotein coagulation factor that plays an important role in intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that can be activated by coagulation factor XIIa, thrombin or factor XIa to generate active factor XIa protease. Mice lacking the encoded protein display a survival advantage during peritoneal sepsis and resist inflammation and bacterial accumulation upon infection with Listeria. [provided by RefSeq, Apr 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK005546.1, BC019485.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849380 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Reaction=Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.; EC=3.4.21.27; Inhibited by SERPINA5. Homodimer; disulfide-linked. Forms a heterodimer with SERPINA5. After activation the heavy and light chains are also linked by a disulfide bond (By similarity). Secreted. Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-389 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Belongs to the peptidase S1 family. Plasma kallikrein subfamily. serine-type endopeptidase activity extracellular region extracellular space proteolysis blood coagulation hemostasis heparin binding peptidase activity serine-type peptidase activity hydrolase activity regulation of blood coagulation plasminogen activation identical protein binding positive regulation of fibrinolysis serine-type aminopeptidase activity uc009los.1 uc009los.2 uc009los.3 uc009los.4 
ENSMUST00000034065.14 Nek1 ENSMUST00000034065.14 NIMA (never in mitosis gene a)-related expressed kinase 1, transcript variant 3 (from RefSeq NM_175089.4) ENSMUST00000034065.1 ENSMUST00000034065.10 ENSMUST00000034065.11 ENSMUST00000034065.12 ENSMUST00000034065.13 ENSMUST00000034065.2 ENSMUST00000034065.3 ENSMUST00000034065.4 ENSMUST00000034065.5 ENSMUST00000034065.6 ENSMUST00000034065.7 ENSMUST00000034065.8 ENSMUST00000034065.9 NEK1_MOUSE NM_175089 P51954 uc009ltt.1 uc009ltt.2 uc009ltt.3 uc009ltt.4 Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:1382974). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:18843199). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (By similarity). May be implicated in the control of meiosis (PubMed:1382974). Involved in cilium assembly (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Binds to CBY2 (PubMed:12204287). Found in a complex with CFAP410, NEK1 and SPATA7 (By similarity). Interacts with CFAP410 (By similarity). Interacts (via Ser-997 phosphorylated form) with 14-3-3 proteins (PubMed:28235073). Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Associated with the pericentriolar material (By similarity). Localizes to centrosome during interphase and mitosis (PubMed:16267153). Predominantly in testes (germ cells and Sertoli cells). Lower levels in ovary (oocytes and granulosa cells), thymus and lung. In female, expressed as follicles enter the secondary stage until ovulation occurs. In the male reproductive system, the expression is limited to spermatocytes and spermatids. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. nucleotide binding pericentriolar material kidney development protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity ATP binding nucleus cytoplasm centrosome microtubule organizing center cytoskeleton protein phosphorylation cellular response to DNA damage stimulus cell cycle spermatogenesis response to ionizing radiation kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation signal transduction by protein phosphorylation cell projection organization activation of protein kinase activity multicellular organism growth DNA damage response, detection of DNA damage metal ion binding cell division cilium assembly 14-3-3 protein binding regulation of DNA damage checkpoint uc009ltt.1 uc009ltt.2 uc009ltt.3 uc009ltt.4 
ENSMUST00000034074.8 N4bp1 ENSMUST00000034074.8 NEDD4 binding protein 1 (from RefSeq NM_030563.2) ENSMUST00000034074.1 ENSMUST00000034074.2 ENSMUST00000034074.3 ENSMUST00000034074.4 ENSMUST00000034074.5 ENSMUST00000034074.6 ENSMUST00000034074.7 Kiaa0615 N4BP1_MOUSE N4bp1 NM_030563 Q3TCI4 Q3UH87 Q3UY69 Q6A037 uc009mqo.1 uc009mqo.2 uc009mqo.3 Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation (PubMed:32971525). Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults (PubMed:32971525). In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (PubMed:32971525). Acts as a restriction factor against some viruses: restricts viral replication by binding to mRNA viruses and mediating their degradation via its ribonuclease activity (By similarity). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (PubMed:17592138). Proteolytic cleavage by CASP8 or MALT1 leads to its inactivation. Interacts with NEDD4 (PubMed:11717310). Interacts with ITCH (via WW domain 2) (PubMed:17592138). Cytoplasm, cytosol Nucleus Nucleus, nucleolus Nucleus, PML body Note=Primarily localizes to the nucleolus (PubMed:20233849). Also localizes to the PML nuclear bodies, when desumoylated (PubMed:20233849). The CoCUN region mediates binding to ubiquitin. Does not interact with NEDD8. Proteolytically cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation (PubMed:32971525). Mainly cleaved at Asp- 488 by CASP8 (PubMed:32971525). Cleaved by caspase-like protein MALT1, leading to its inactivation (By similarity). Mono- and polyubiquitinated on the CoCUN region (By similarity). Monoubiquitinated by NEDD4 (PubMed:11717310). Polyubiquitinated, leading to its degradation by the proteasome (PubMed:20233849). Sumoylated with SUMO1, abrogating polyubiquitination and subsequent degradation (PubMed:20233849). Desumoylated by SENP1, leading to accumulation in PML nuclear bodies (PubMed:20233849). Mice are viable, fertile and grossly normal, but develop mild, age-dependent inflammation and immune dysregulation. Belongs to the N4BP1 family. Sequence=BAD32259.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA binding protein binding nucleus nucleolus PML body negative regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to UV uc009mqo.1 uc009mqo.2 uc009mqo.3 
ENSMUST00000034076.16 Cbln1 ENSMUST00000034076.16 cerebellin 1 precursor protein (from RefSeq NM_019626.3) CBLN1_MOUSE ENSMUST00000034076.1 ENSMUST00000034076.10 ENSMUST00000034076.11 ENSMUST00000034076.12 ENSMUST00000034076.13 ENSMUST00000034076.14 ENSMUST00000034076.15 ENSMUST00000034076.2 ENSMUST00000034076.3 ENSMUST00000034076.4 ENSMUST00000034076.5 ENSMUST00000034076.6 ENSMUST00000034076.7 ENSMUST00000034076.8 ENSMUST00000034076.9 NM_019626 P28655 Q9QVT5 Q9R171 uc009mqr.1 uc009mqr.2 uc009mqr.3 Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber- Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses (PubMed:16234806). Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components (PubMed:20395510). On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2 (PubMed:21410790). NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles (PubMed:23141067). Required for CBLN3 export from the endoplasmic reticulum and secretion (PubMed:17030622, PubMed:17331201). NRXN1- CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (By similarity). Essential for long-term maintenance but not establishment of excitatory synapses (PubMed:29691328). Inhibits the formation and function of inhibitory GABAergic synapses in cerebellar Purkinje cells (PubMed:24467251). The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity). Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the globular C1q domains. The trimers associate via N- terminal cysteine residues to form disulfide-linked hexamers (PubMed:16135095). May form oligomers with CBLN2, CBLN3 and CBLN4 prior to secretion (PubMed:29782851). Once secreted, does not interact with other CBLN family members (PubMed:17030622, PubMed:17331201, PubMed:10964938). Interacts with GRID1 (PubMed:22220752). Interacts with NRXN1 and NRXN2 long (alpha) and short (beta) isoforms produced by alternative promoter usage (PubMed:21410790, PubMed:22220752, PubMed:29782851). Competes with NLGN1 for NRXN1-binding. Weakly interacts with NRXN3 short isoform and not at all with NRXN3 long isoform (PubMed:21410790, PubMed:22220752, PubMed:29782851). Interacts (via C1q domain) with GRID2; GRID2-binding is calcium-independent; CBLN1 hexamers anchor GRID2 N-terminal domain dimers to monomeric NRXN1 isoform beta; promotes synaptogenesis and mediates the D-Serine- dependent long term depression signals and AMPA receptor endocytosis (PubMed:20395510, PubMed:21410790, PubMed:22220752, PubMed:29782851). Interacts with OTOL1 (PubMed:20856818). Q9R171; Q61625: Grid2; NbExp=8; IntAct=EBI-2794140, EBI-2794106; Q9R171; P0DI97: Nrxn1; NbExp=4; IntAct=EBI-2794140, EBI-2794440; Secreted stsynaptic cell membrane Note=Interaction with CBLN3 may cause partial retention in the endoplasmic reticulum. Expressed and secreted by presynaptic neurons, such as cerebellar granule cells. Following secretion, the protein binds to GRID2 on the postsynaptic Purkinje cell membranes. Expressed at the highest level in the cerebellar cortex. High levels are also seen in the olfactory bulb, posterior part of the cerebral cortex, certain thalamic nuclei, and deep cerebellar nuclei. Low to moderate levels are detected in some hypothalamic and brainstem nuclei. In the thalamus, expressed in parafascicular nucleus neurons and other regions (at protein level). In the developing brain, expressed as early as embryonic day 10-13, and transiently up-regulated during the late embryonic and neonatal periods. Cerebellin and [des-Ser1]-cerebellin are expressed as easly as postnatal day 3-4. The levels of both peptides rise rapidly to a maximum at approximately day 25-30 after birth, whereafter they fall to stable adult values. The proteolytic processing to yield cerebellin seems to occur either prior to the secretion by presynaptic neurons and subsequent oligomerization or in some other location after release of the mature protein. In the cerebellum, cerebellin is much more abundant than [des- Ser1]-cerebellin. Sialoglycoprotein. Mice (reeler, weaver and staggerer) show defects in granule cell migration and parallel fiber formation, synaptogenesis, Purkinje cell dendritic maturation and establishment of adult cytoarchitecture show a correlation between the formation and number of parallel fiber-Purkinje cell synapses and cerebellin levels (PubMed:3199194). CBLN1 single knockout mice show a major impairment in motor behaviors (PubMed:3420533). Double CBLN1 and CBLN2 knockout mice exhibit gait abnormalities, impairments in balance and coordination and develop seizures (PubMed:3420533). Synapse density in the hippocampus is normal in 1-2 months old mice, but severely decreased in 6 month old mice (PubMed:3420533). Triple CBLN1, CBLN2 and CBLN4 knockout mice exhibit impairments in sensory processing and sensorimotor gating, in addition to severe motor deficits, seizures and reduced synapse density in the hippocampus of aging mice (PubMed:3420533). Sequence=CAA43688.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; protein binding extracellular region plasma membrane heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules protein secretion membrane cerebellar granule cell differentiation cell junction protein homodimerization activity synaptic cleft synapse postsynaptic membrane positive regulation of synapse assembly negative regulation of excitatory postsynaptic potential glutamatergic synapse positive regulation of long term synaptic depression regulation of presynapse assembly uc009mqr.1 uc009mqr.2 uc009mqr.3 
ENSMUST00000034079.14 Heatr3 ENSMUST00000034079.14 HEAT repeat containing 3 (from RefSeq NM_172757.3) ENSMUST00000034079.1 ENSMUST00000034079.10 ENSMUST00000034079.11 ENSMUST00000034079.12 ENSMUST00000034079.13 ENSMUST00000034079.2 ENSMUST00000034079.3 ENSMUST00000034079.4 ENSMUST00000034079.5 ENSMUST00000034079.6 ENSMUST00000034079.7 ENSMUST00000034079.8 ENSMUST00000034079.9 HEAT3_MOUSE NM_172757 Q8BQM4 Q8C731 uc009mrd.1 uc009mrd.2 uc009mrd.3 uc009mrd.4 Plays a role in ribosome biogenesis and in nuclear import of the 60S ribosomal protein L5/large ribosomal subunit protein uL18 (RPL5). Required for proper erythrocyte maturation. cell protein import into nucleus ribosomal large subunit biogenesis unfolded protein binding uc009mrd.1 uc009mrd.2 uc009mrd.3 uc009mrd.4 
ENSMUST00000034085.8 Brd7 ENSMUST00000034085.8 bromodomain containing 7, transcript variant 1 (from RefSeq NM_012047.3) BRD7_MOUSE Bp75 ENSMUST00000034085.1 ENSMUST00000034085.2 ENSMUST00000034085.3 ENSMUST00000034085.4 ENSMUST00000034085.5 ENSMUST00000034085.6 ENSMUST00000034085.7 NM_012047 O88665 Q3UQ56 Q3UU06 Q9CT78 uc009mrn.1 uc009mrn.2 uc009mrn.3 uc009mrn.4 Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down- regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR. Interacts with IRF2 and HNRPUL1 (By similarity). Interacts (via N-terminus) with TP53. Interacts (via C-terminus) with EP300. Interacts with BRCA1. Interacts (via bromo domain) with histone H3 (via N-terminus) acetylated at 'Lys-14' (H3K14ac). Has low affinity for histone H3 acetylated at 'Lys-9' (H3K9ac). Has the highest affinity for histone H3 that is acetylated both at 'Lys-9' (H3K9ac) and at 'Lys-14' (H3K14ac). Has very low affinity for non-acetylated histone H3. Interacts (via bromo domain) with histone H4 (via N-terminus) acetylated at 'Lys-8' (H3K8ac) (in vitro) (By similarity). Interacts with TRIM24, PTPN13 and DVL1. Identified in a complex with SMARCA4/BRG1, SMARCC1/BAF155, SMARCE1/BAF57, DPF2/BAF45D and ARID2, subunits of the SWI/SNF-B (PBAF) chromatin remodeling complex. O88665; P26450: Pik3r1; NbExp=11; IntAct=EBI-643930, EBI-641764; O88665; O08908: Pik3r2; NbExp=4; IntAct=EBI-643930, EBI-643570; O88665; Q64512: Ptpn13; NbExp=3; IntAct=EBI-643930, EBI-4284057; Nucleus romosome Ubiquitous. Expressed ubiquitously from 10.5 to 18.5 dpc. Sequence=BAE23823.1; Type=Erroneous initiation; Evidence=; p53 binding transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm cytosol regulation of transcription from RNA polymerase II promoter cell cycle transcription factor binding negative regulation of cell proliferation Wnt signaling pathway positive regulation of histone acetylation histone binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated lysine-acetylated histone binding negative regulation of G1/S transition of mitotic cell cycle uc009mrn.1 uc009mrn.2 uc009mrn.3 uc009mrn.4 
ENSMUST00000034086.13 Nkd1 ENSMUST00000034086.13 naked cuticle 1, transcript variant 1 (from RefSeq NM_027280.3) ENSMUST00000034086.1 ENSMUST00000034086.10 ENSMUST00000034086.11 ENSMUST00000034086.12 ENSMUST00000034086.2 ENSMUST00000034086.3 ENSMUST00000034086.4 ENSMUST00000034086.5 ENSMUST00000034086.6 ENSMUST00000034086.7 ENSMUST00000034086.8 ENSMUST00000034086.9 NKD1_MOUSE NM_027280 Q3TLD6 Q8K200 Q91Y46 Q99MH6 uc009mro.1 uc009mro.2 uc009mro.3 uc009mro.4 Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for spermatogenesis. Interacts with DVL1, DVL2, DVL3 and PPP2R3A. Q99MH6; P51140: dsh; Xeno; NbExp=2; IntAct=EBI-1538321, EBI-499383; Cell membrane Cytoplasm Highly expressed in lung. Also expressed in brain, heart, kidney, liver, skin, stomach and testis. Within the testis expression is found in the seminiferous epithelium and round and elongating spermatids. Expressed throughout embryonic development. Expressed in the presomitic mesoderm (PSM) and the neural folds along the entire rostrocaudal axis at 8.5 days post-coitum (dpc). Expressed in the forelimb buds, the branchial arches, and at the anterior and posterior of each somite boundary at 9.5 dpc. Expressed in the neural tube, the PSM, somites and the dorsal limb bud mesenchyme at 10.5 dpc. At 11.5 dpc three distinct phases of expression can be seen; expression is initially low in the tailbud, rises in the PSM and then shifts anteriorly. These oscillations require the activity of HES7. Expression is induced by activation of the Wnt signaling pathway. Belongs to the NKD family. Sequence=BAE38856.1; Type=Frameshift; Evidence=; protein phosphatase type 2A complex calcium ion binding protein binding cytoplasm plasma membrane multicellular organism development spermatogenesis membrane Wnt signaling pathway cell differentiation PDZ domain binding negative regulation of Wnt signaling pathway positive regulation of protein catabolic process metal ion binding negative regulation of canonical Wnt signaling pathway positive regulation of non-canonical Wnt signaling pathway via JNK cascade negative regulation of convergent extension involved in axis elongation positive regulation of Wnt signaling pathway, planar cell polarity pathway uc009mro.1 uc009mro.2 uc009mro.3 uc009mro.4 
ENSMUST00000034087.9 Snx20 ENSMUST00000034087.9 sorting nexin 20 (from RefSeq NM_027840.3) A0A0R4J0D0 A0A0R4J0D0_MOUSE ENSMUST00000034087.1 ENSMUST00000034087.2 ENSMUST00000034087.3 ENSMUST00000034087.4 ENSMUST00000034087.5 ENSMUST00000034087.6 ENSMUST00000034087.7 ENSMUST00000034087.8 NM_027840 Snx20 uc009mrp.1 uc009mrp.2 uc009mrp.3 Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the sorting nexin family. nucleoplasm protein transport phosphatidylinositol binding uc009mrp.1 uc009mrp.2 uc009mrp.3 
ENSMUST00000034090.8 Sall1 ENSMUST00000034090.8 spalt like transcription factor 1 (from RefSeq NM_021390.3) ENSMUST00000034090.1 ENSMUST00000034090.2 ENSMUST00000034090.3 ENSMUST00000034090.4 ENSMUST00000034090.5 ENSMUST00000034090.6 ENSMUST00000034090.7 NM_021390 Q6P5E3 Q6P5E3_MOUSE Sall1 uc009msa.1 uc009msa.2 uc009msa.3 uc009msa.4 uc009msa.5 uc009msa.6 Nucleus Belongs to the sal C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter heterochromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding kidney development mesenchymal to epithelial transition involved in metanephros morphogenesis nucleic acid binding nucleus cytoplasm heart development beta-catenin binding gonad development chromocenter pituitary gland development positive regulation of Wnt signaling pathway adrenal gland development outer ear morphogenesis embryonic digit morphogenesis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic digestive tract development limb development olfactory bulb mitral cell layer development uc009msa.1 uc009msa.2 uc009msa.3 uc009msa.4 uc009msa.5 uc009msa.6 
ENSMUST00000034091.8 Rbl2 ENSMUST00000034091.8 RB transcriptional corepressor like 2, transcript variant 1 (from RefSeq NM_011250.4) ENSMUST00000034091.1 ENSMUST00000034091.2 ENSMUST00000034091.3 ENSMUST00000034091.4 ENSMUST00000034091.5 ENSMUST00000034091.6 ENSMUST00000034091.7 NM_011250 Q3TVP8 Q64700 RBL2_MOUSE uc012gid.1 uc012gid.2 uc012gid.3 Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. Interacts with AATF and RINT1. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle- dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with USP4 (By similarity). Interacts with KMT5B, KMT5C and USP4. Interacts with PML (By similarity). Interacts with RBBP9 (By similarity). Q64700; Q155P7: Cenpf; NbExp=3; IntAct=EBI-2271232, EBI-2211248; Nucleus. During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-636 and on 5 sites within the domain B. Phosphorylation on Ser-669 in G1 leads to its ubiquitin-dependent proteolysis (By similarity). Belongs to the retinoblastoma protein (RB) family. chromatin RNA polymerase II regulatory region DNA binding RNA polymerase II activating transcription factor binding DNA binding protein binding nucleus nucleoplasm transcription factor complex nucleolus cytosol chromatin organization regulation of transcription from RNA polymerase II promoter cell cycle regulation of mitotic cell cycle negative regulation of gene expression cell differentiation regulation of lipid kinase activity regulation of cell division regulation of cell cycle promoter-specific chromatin binding negative regulation of G1/S transition of mitotic cell cycle uc012gid.1 uc012gid.2 uc012gid.3 
ENSMUST00000034093.15 Eif2ak3 ENSMUST00000034093.15 eukaryotic translation initiation factor 2 alpha kinase 3, transcript variant 1 (from RefSeq NM_010121.3) E9QQ30 E9QQ30_MOUSE ENSMUST00000034093.1 ENSMUST00000034093.10 ENSMUST00000034093.11 ENSMUST00000034093.12 ENSMUST00000034093.13 ENSMUST00000034093.14 ENSMUST00000034093.2 ENSMUST00000034093.3 ENSMUST00000034093.4 ENSMUST00000034093.5 ENSMUST00000034093.6 ENSMUST00000034093.7 ENSMUST00000034093.8 ENSMUST00000034093.9 Eif2ak3 NM_010121 uc009cgb.1 uc009cgb.2 uc009cgb.3 uc009cgb.4 The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in a similar gene in human are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. ossification angiogenesis protein kinase activity protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity ATP binding protein phosphorylation ER overload response positive regulation of vascular endothelial growth factor production positive regulation of gene expression enzyme binding protein phosphatase binding endoplasmic reticulum unfolded protein response endocrine pancreas development negative regulation of translation in response to stress cellular response to amino acid starvation response to endoplasmic reticulum stress eiF2alpha phosphorylation in response to endoplasmic reticulum stress cellular response to glucose starvation identical protein binding positive regulation of transcription from RNA polymerase I promoter protein autophosphorylation perinuclear region of cytoplasm protein homooligomerization Hsp90 protein binding cellular response to cold regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway response to manganese-induced endoplasmic reticulum stress uc009cgb.1 uc009cgb.2 uc009cgb.3 uc009cgb.4 
ENSMUST00000034094.11 Gins3 ENSMUST00000034094.11 GINS complex subunit 3 (from RefSeq NM_030198.3) ENSMUST00000034094.1 ENSMUST00000034094.10 ENSMUST00000034094.2 ENSMUST00000034094.3 ENSMUST00000034094.4 ENSMUST00000034094.5 ENSMUST00000034094.6 ENSMUST00000034094.7 ENSMUST00000034094.8 ENSMUST00000034094.9 NM_030198 PSF3_MOUSE Psf3 Q9CY94 uc009myr.1 uc009myr.2 uc009myr.3 Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS2. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex. Nucleus Chromosome Note=Associates with chromatin. Belongs to the GINS3/PSF3 family. molecular_function nucleus nucleoplasm DNA replication uc009myr.1 uc009myr.2 uc009myr.3 
ENSMUST00000034096.6 Setd6 ENSMUST00000034096.6 SET domain containing 6, transcript variant 4 (from RefSeq NR_160791.1) B2RTA7 ENSMUST00000034096.1 ENSMUST00000034096.2 ENSMUST00000034096.3 ENSMUST00000034096.4 ENSMUST00000034096.5 NR_160791 Q8C6I1 Q9CWY3 SETD6_MOUSE uc009myv.1 uc009myv.2 uc009myv.3 Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (PubMed:23324626). Methylates PAK4. Reaction=L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:51736, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13053, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51737; Evidence=; Reaction=L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:67808, Rhea:RHEA-COMP:17357, Rhea:RHEA-COMP:17358, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67809; Evidence=; Monomer, homodimer and homotrimer; these structures are stabilized in the presence of S-adenosyl-L-methionine (SAM). Q9CWY3; Q9UHL9: GTF2IRD1; Xeno; NbExp=3; IntAct=EBI-10768425, EBI-372530; Nucleus Automethylated. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. Sequence=BAC35846.1; Type=Frameshift; Evidence=; protein binding nucleus cytosol methyltransferase activity protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine monomethylation stem cell population maintenance negative regulation of NF-kappaB transcription factor activity methylation histone lysine methylation stem cell differentiation regulation of inflammatory response NF-kappaB binding uc009myv.1 uc009myv.2 uc009myv.3 
ENSMUST00000034097.8 Got2 ENSMUST00000034097.8 glutamatic-oxaloacetic transaminase 2, mitochondrial (from RefSeq NM_010325.3) AATM_MOUSE ENSMUST00000034097.1 ENSMUST00000034097.2 ENSMUST00000034097.3 ENSMUST00000034097.4 ENSMUST00000034097.5 ENSMUST00000034097.6 ENSMUST00000034097.7 Got-2 NM_010325 O09188 P05202 Q3TIP6 Q3UD91 Q5HZH5 uc009mzi.1 uc009mzi.2 uc009mzi.3 Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. Reaction=2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate; Xref=Rhea:RHEA:21824, ChEBI:CHEBI:16452, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:29991; EC=2.6.1.1; Evidence=; Reaction=2-oxoglutarate + L-kynurenine = H2O + kynurenate + L- glutamate; Xref=Rhea:RHEA:65560, ChEBI:CHEBI:15377, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454; EC=2.6.1.7; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Homodimer. Mitochondrion matrix. Cell membrane Detected in brain (at protein level). Acetylation of Lys-296, Lys-345 and Lys-363 is observed in liver mitochondria from fasted mice but not from fed mice. In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. catalytic activity L-aspartate:2-oxoglutarate aminotransferase activity phospholipid binding mitochondrion mitochondrial inner membrane mitochondrial matrix plasma membrane 2-oxoglutarate metabolic process oxaloacetate metabolic process cellular amino acid metabolic process aspartate metabolic process aspartate biosynthetic process aspartate catabolic process glutamate metabolic process lipid transport female pregnancy lactation transaminase activity biosynthetic process cell surface response to muscle activity fatty acid transport membrane kynurenine-oxoglutarate transaminase activity amino acid binding transferase activity glutamate catabolic process to aspartate glutamate catabolic process to 2-oxoglutarate enzyme binding pyridoxal phosphate binding T-tubule carboxylic acid binding response to insulin macromolecular complex sarcolemma protein homodimerization activity perikaryon myelin sheath response to morphine dicarboxylic acid metabolic process response to ethanol L-kynurenine metabolic process uc009mzi.1 uc009mzi.2 uc009mzi.3 
ENSMUST00000034109.6 1700011L22Rik ENSMUST00000034109.6 RIKEN cDNA 1700011L22 gene (from RefSeq NM_026315.1) CD051_MOUSE ENSMUST00000034109.1 ENSMUST00000034109.2 ENSMUST00000034109.3 ENSMUST00000034109.4 ENSMUST00000034109.5 G3X910 NM_026315 Q9DAF8 uc009mil.1 uc009mil.2 uc009mil.3 uc009mil.4 molecular_function cellular_component biological_process uc009mil.1 uc009mil.2 uc009mil.3 uc009mil.4 
ENSMUST00000034111.10 Slc10a7 ENSMUST00000034111.10 solute carrier family 10 (sodium/bile acid cotransporter family), member 7, transcript variant a (from RefSeq NM_029736.2) ENSMUST00000034111.1 ENSMUST00000034111.2 ENSMUST00000034111.3 ENSMUST00000034111.4 ENSMUST00000034111.5 ENSMUST00000034111.6 ENSMUST00000034111.7 ENSMUST00000034111.8 ENSMUST00000034111.9 NM_029736 NTCP7_MOUSE P7 Q5PT51 Q5PT53 Q8BV58 Q8BYD0 Q9CWD6 uc009mid.1 uc009mid.2 uc009mid.3 uc009mid.4 Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization (PubMed:30082715). Also involved in the regulation of cellular calcium homeostasis (By similarity). Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate). Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5PT53-1; Sequence=Displayed; Name=2; IsoId=Q5PT53-2; Sequence=VSP_023226; Name=3; IsoId=Q5PT53-3; Sequence=VSP_023225; Expressed in heart, brain, colon, lung, liver, adrenal gland, stomach and ovary. Also expressed weakly in small intestine. Expressed in skeletal tissues (PubMed:30082715). Embryos at gestational age 12.5 dpc show the weakest SLC10A7 expression, mainly in the heart trabeculae of the developing heart and the cartilage of the vertebrae. From 14.5 dpc onwards, expression becomes more ubiquitous, with the strongest level observed at 16.5 dpc and postnatal day P0. At 14.5 dpc, it is strongly expressed in cartilaginous structures in the mandible, in the epithelial compartment of cap stage teeth, in the digits, in the spine and in the lung. At 16.5 dpc, transcripts are mostly localized in the inner dental epithelium and in the epithelial loop of bell stage teeth. At 18.5 dpc expression is observed in the inner dental epithelium of incisors, and in ameloblasts and odontoblasts of molars. At postnatal day P0 there is strong expression in the papillary layer of the oral mucous membrane underneath the palate, as well as in the ameloblast layer of emerging teeth. At postnatal day P10, it is localized to the growth plate of several long bones, such as the forefoot digits, the hindfoot tarsals and the humerus, and expression is more intense in the chondrocytes of the hypertrophic zone. Knockout mice present with skeletal dysplasia including growth retardation at birth and at 8 weeks, alteration of long-bone morphology, craniofacial anomalies and advanced tarsal maturation at birth, associated with enamel defects. The proportion of heparan sulfate (HS) in cartilage of knockout mice is significantly reduced compared with wild-type animals. SLC10A7 deficiency has no impact on skeletal muscle heparan sulfate levels. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. Sequence=BAC30613.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus Golgi medial cisterna cis-Golgi network trans-Golgi network plasma membrane ion transport sodium ion transport cellular calcium ion homeostasis bile acid transmembrane transporter activity symporter activity bile acid and bile salt transport membrane integral component of membrane heparin biosynthetic process intrinsic component of plasma membrane glycoprotein transport Golgi vesicle transport transmembrane transport bone development uc009mid.1 uc009mid.2 uc009mid.3 uc009mid.4 
ENSMUST00000034115.5 Pou4f2 ENSMUST00000034115.5 POU domain, class 4, transcription factor 2 (from RefSeq NM_138944.3) Brn-3.2 Brn3b ENSMUST00000034115.1 ENSMUST00000034115.2 ENSMUST00000034115.3 ENSMUST00000034115.4 NM_138944 PO4F2_MOUSE Pou4f2 Q63934 Q63954 uc009mhy.1 uc009mhy.2 uc009mhy.3 Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:7904822, PubMed:8995448, PubMed:8972215, PubMed:10357904, PubMed:10414983, PubMed:11163266, PubMed:17668438, PubMed:25775587). Functions either as activator or repressor by modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:7904822, PubMed:7935408, PubMed:8065921, PubMed:7852360, PubMed:7797498, PubMed:8662774, PubMed:9694219, PubMed:10526314, PubMed:15733064, PubMed:17145718, PubMed:18368538). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes (PubMed:7904822, PubMed:8290353, PubMed:9111308, PubMed:10414983, PubMed:16152597, PubMed:17668438, PubMed:24643061). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation (PubMed:8632990, PubMed:10357904, PubMed:25775587). Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding (PubMed:8995448, PubMed:9261145, PubMed:8972215, PubMed:10357904, PubMed:11163266, PubMed:24643061, PubMed:25775587). Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification (PubMed:21875655). In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis (PubMed:17145718). Negatively regulates BAX promoter activity in the absence of TP53 (PubMed:17145718). Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter (PubMed:9448000). Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif (PubMed:7935408, PubMed:8065921, PubMed:8537352, PubMed:7852360, PubMed:8662774). Involved in TNFSF11-mediated terminal osteoclast differentiation (PubMed:17668438). Isoform 2: Interacts with POU4F1 isoform 1; this interaction inhibits both POU4F1 DNA-binding and transcriptional activities (PubMed:8537352). Isoform 2: Interacts (C-terminus) with ESR1 (via DNA- binding domain); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol- independent manner (PubMed:9448000). Isoform 2: Interacts (via C- terminus) with TP53 (via N-terminus) (PubMed:17145718). Interacts with DLX1 (via homeobox DNA-binding domain); this interaction suppresses DLX1-mediated transcriptional activity in postnatal retina enhancing retinal ganglion cell (RGC) differentiation (PubMed:21875655). Interacts with DLX2 (via homeobox DNA-binding domain); this interaction enhances RGC differentiation (PubMed:21875655). Isoform 1: Interacts (via C-terminus) with ISL1 (via C-terminus) (PubMed:24643061). Isoform 1: Interacts with ISL2 (PubMed:24643061). Isoform 1: Interacts with LHX2 (PubMed:24643061). Nucleus Nucleus speckle Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Brn-3b-long , Brn-3b-l ; IsoId=Q63934-1; Sequence=Displayed; Name=2; Synonyms=Brn-3b rn-3b-short , Brn-3b-s ; IsoId=Q63934-2; Sequence=VSP_058838; Expressed in retinal ganglion cells (RGCs) (PubMed:21875655, PubMed:23805044). Expressed in mature osteoclasts (PubMed:17668438). Expressed in cells of layers of the superior colliculus and the adjacent periaqueductal gray (at protein level) (PubMed:7691107). Expressed in the brain, peripheral sensory nervous system and retina (PubMed:7904822). Expressed in the optical, intermediate, and deep gray areas of the superior colliculus, the dorsal column of the mesencephalic and pontine central gray, and the lateral interpeduncular nucleus of the brain (PubMed:7904822). Expressed predominantly in postmitotic, terminally differentiated neurons (PubMed:7904822). Expressed in ganglion cell layer (GCL) of the retina (PubMed:7691107, PubMed:23805044). Weakly expressed in the dorsal root ganglion neurons at 10.5 dpc, the expression increases at least until 15.5 dpc (PubMed:22326227). Expressed in the developing ganglion cell layer of the retina at 12.5, 13.5 and 16.5 dpc (PubMed:8632990). Expressed in the outer margin of the retina at 15.5 dpc (PubMed:10414983). Expressed in embryonic heart from 13.5 dpc until birth (at protein level) (PubMed:18368538). Expressed in the developing spinal cord from 13 dpc until postnatal day 1 (PubMed:8290353, PubMed:8537352). Expressed in retinal ganglion cells (RGC) at 13.5 dpc, peaks at 15.5 dpc, declining later in development (PubMed:8637595). Up-regulated by the osteoclast differentiation factor TNFSF11 (PubMed:17668438). Down-regulated upon neuronal differentiation (PubMed:8995448). Down-regulated in presence of retinoic acid (PubMed:7904822). Down-regulated by dibutyryl cyclic AMP (PubMed:8065921). The N-terminal transcriptional activation region is sufficient to induce transcriptional activity. The POU-specific domain and POU homeodomain regions are necessary for DNA-binding activity and transcriptional repression. The polyhistidine motif acts as a targeting signal to nuclear speckles. Mice develop to adulthood and are fertile (PubMed:8637595). Show a reduction in the number of retinal ganglion cells (RGC) and a thinner optic nerve compared to wild-type mice (PubMed:8637595, PubMed:8632990, PubMed:10357904). Show RGC axon pathfinding alterations along the central visual pathways (PubMed:10357904, PubMed:11163266). Show an alteration in the expression levels for several genes involved in the differentiation of RGCs (PubMed:24643061, PubMed:25775587). Display an increase in DLX1 and DLX2 mRNA expression in the embryonic retina, especially in the ganglion cell layer (PubMed:21875655). Belongs to the POU transcription factor family. Class-4 subfamily. negative regulation of transcription from RNA polymerase II promoter MAPK cascade RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity transcription corepressor activity protein binding nucleus transcription factor complex nuclear euchromatin cytoplasm regulation of transcription, DNA-templated apoptotic process multicellular organism development spermatogenesis axonogenesis axon guidance heart development sensory perception of sound regulation of gene expression positive regulation of cardiac muscle cell apoptotic process nuclear speck cell differentiation neuron differentiation intracellular estrogen receptor signaling pathway retinal ganglion cell axon guidance cellular response to insulin stimulus positive regulation of programmed cell death negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding negative regulation of cell differentiation positive regulation of cell differentiation positive regulation of osteoclast differentiation positive regulation of axon extension positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import axon extension neuromuscular process controlling balance regulation of sequence-specific DNA binding transcription factor activity retina development in camera-type eye cellular response to cytokine stimulus cellular response to estradiol stimulus cellular response to oxygen levels intrinsic apoptotic signaling pathway by p53 class mediator regulation of retinal ganglion cell axon guidance negative regulation of amacrine cell differentiation positive regulation of nucleic acid-templated transcription negative regulation of adipose tissue development dorsal root ganglion development promoter-specific chromatin binding positive regulation of transcription regulatory region DNA binding uc009mhy.1 uc009mhy.2 uc009mhy.3 
ENSMUST00000034121.11 Man2b1 ENSMUST00000034121.11 mannosidase 2, alpha B1, transcript variant 1 (from RefSeq NM_010764.3) ENSMUST00000034121.1 ENSMUST00000034121.10 ENSMUST00000034121.2 ENSMUST00000034121.3 ENSMUST00000034121.4 ENSMUST00000034121.5 ENSMUST00000034121.6 ENSMUST00000034121.7 ENSMUST00000034121.8 ENSMUST00000034121.9 Laman MA2B1_MOUSE Man2b Manb NM_010764 O09159 O55037 Q3UGH3 Q64443 Q9DBQ1 uc009mpk.1 uc009mpk.2 uc009mpk.3 Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Reaction=Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.; EC=3.2.1.24; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Lysosome. Belongs to the glycosyl hydrolase 38 family. Sequence=AAC09470.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAC53369.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; catalytic activity alpha-mannosidase activity mannose binding extracellular space lysosome vacuolar membrane carbohydrate metabolic process mannose metabolic process cellular protein modification process protein deglycosylation learning or memory metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds carbohydrate binding metal ion binding uc009mpk.1 uc009mpk.2 uc009mpk.3 
ENSMUST00000034131.10 Vps35 ENSMUST00000034131.10 VPS35 retromer complex component (from RefSeq NM_022997.5) ENSMUST00000034131.1 ENSMUST00000034131.2 ENSMUST00000034131.3 ENSMUST00000034131.4 ENSMUST00000034131.5 ENSMUST00000034131.6 ENSMUST00000034131.7 ENSMUST00000034131.8 ENSMUST00000034131.9 Mem3 NM_022997 Q61123 Q9EQH3 VPS35_MOUSE uc009mpo.1 uc009mpo.2 uc009mpo.3 Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for endosomal localization of WASHC2 and mediates the association of the CSC with the WASH complex (By similarity). Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS) formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35. The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform (PubMed:21040701, PubMed:20875039, PubMed:21920005). The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the affinity between the respective CSC and SNX-BAR subcomplexes is low. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27- retromer complex (Probable). Interacts with VPS26A, VPS29, VPS26B and LRRK2 (PubMed:16190980, PubMed:21040701, PubMed:20875039, PubMed:21920005, PubMed:23395371). Interacts with SNX1, SNX2, IGF2R, SNX3, GOLPH3, SLC11A2, WASHC2, FKBP15, WASHC1, EHD1. Interacts with MAGEL2; leading to recruitment of the TRIM27:MAGEL2 E3 ubiquitin ligase complex retromer-containing endosomes (By similarity). Interacts with SORCS2 (PubMed:28469074). Q9EQH3; O88307: Sorl1; NbExp=2; IntAct=EBI-775825, EBI-7540114; Q9EQH3; Q6PHU5: Sort1; NbExp=3; IntAct=EBI-775825, EBI-6985663; Q9EQH3; P40336-1: Vps26a; NbExp=2; IntAct=EBI-775825, EBI-15553779; Q9EQH3; Q9QZ88: Vps29; NbExp=5; IntAct=EBI-775825, EBI-8334188; Q9EQH3; Q9QZ88-1: Vps29; NbExp=3; IntAct=EBI-775825, EBI-15553808; Q9EQH3; Q5T1M5: FKBP15; Xeno; NbExp=3; IntAct=EBI-775825, EBI-5235934; Cytoplasm Membrane ; Peripheral membrane protein Endosome Early endosome Late endosome Detected in striatum (at protein level) (PubMed:28469074). Ubiquitous. Highly expressed in fat tissue, testis, brain, kidney, thymus, liver and pancreas, and at lower levels in heart, intestine and skeletal muscle. Detected in oocytes, pre- implantation embryos and at 6.5-12.5 dpc. Belongs to the VPS35 family. Sequence=AAB18153.1; Type=Frameshift; Evidence=; protein binding cytoplasm mitochondrion lysosome endosome early endosome late endosome cytosol vacuolar protein processing intracellular protein transport lysosome organization synapse assembly endosome membrane positive regulation of gene expression negative regulation of gene expression regulation of mitochondrion organization postsynaptic density protein transport membrane integral component of membrane retromer complex retromer, cargo-selective complex regulation of protein stability protein destabilization D1 dopamine receptor binding regulation of cellular protein metabolic process negative regulation of protein homooligomerization protein localization to organelle protein localization to endosome retrograde transport, endosome to Golgi neuron projection neuronal cell body mitochondrial fragmentation involved in apoptotic process transcytosis perinuclear region of cytoplasm negative regulation of inflammatory response voluntary musculoskeletal movement positive regulation of dopamine receptor signaling pathway negative regulation of cell death positive regulation of Wnt protein secretion positive regulation of mitochondrial fission positive regulation of canonical Wnt signaling pathway positive regulation of locomotion involved in locomotory behavior tubular endosome presynapse postsynapse neurotransmitter receptor transport, endosome to postsynaptic membrane glutamatergic synapse vesicle-mediated transport in synapse mitochondrion-derived vesicle mitochondrion to lysosome transport neurotransmitter receptor transport, endosome to plasma membrane negative regulation of neuron death negative regulation of late endosome to lysosome transport regulation of dendritic spine maintenance positive regulation of dopamine biosynthetic process positive regulation of cellular protein catabolic process negative regulation of cellular protein localization negative regulation of lysosomal protein catabolic process retrograde transport, endosome to plasma membrane regulation of terminal button organization uc009mpo.1 uc009mpo.2 uc009mpo.3 
ENSMUST00000034132.13 Orc6 ENSMUST00000034132.13 origin recognition complex, subunit 6, transcript variant 1 (from RefSeq NM_019716.2) ENSMUST00000034132.1 ENSMUST00000034132.10 ENSMUST00000034132.11 ENSMUST00000034132.12 ENSMUST00000034132.2 ENSMUST00000034132.3 ENSMUST00000034132.4 ENSMUST00000034132.5 ENSMUST00000034132.6 ENSMUST00000034132.7 ENSMUST00000034132.8 ENSMUST00000034132.9 NM_019716 Orc6 Orc6l Q66JV6 Q66JV6_MOUSE uc009mpp.1 uc009mpp.2 uc009mpp.3 uc009mpp.4 Nucleus Belongs to the ORC6 family. origin recognition complex fibrillar center DNA binding nucleus nuclear origin of replication recognition complex DNA replication negative regulation of cell division uc009mpp.1 uc009mpp.2 uc009mpp.3 uc009mpp.4 
ENSMUST00000034133.14 Mylk3 ENSMUST00000034133.14 myosin light chain kinase 3, transcript variant 1 (from RefSeq NM_175441.5) B0LY41 ENSMUST00000034133.1 ENSMUST00000034133.10 ENSMUST00000034133.11 ENSMUST00000034133.12 ENSMUST00000034133.13 ENSMUST00000034133.2 ENSMUST00000034133.3 ENSMUST00000034133.4 ENSMUST00000034133.5 ENSMUST00000034133.6 ENSMUST00000034133.7 ENSMUST00000034133.8 ENSMUST00000034133.9 MYLK3_MOUSE NM_175441 Q3UIZ8 Q3V3V0 Q8BWD1 uc009mps.1 uc009mps.2 uc009mps.3 Kinase that phosphorylates MYL2 in vitro (PubMed:18202317, PubMed:17885681). Has been proposed to be calmodulin-dependent (PubMed:17885681), although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin (PubMed:18202317). Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). Reaction=ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L- seryl-[myosin light chain]; Xref=Rhea:RHEA:22004, Rhea:RHEA- COMP:13684, Rhea:RHEA-COMP:13685, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.18; Evidence=; Reaction=ATP + L-threonyl-[myosin light chain] = ADP + H(+) + O- phospho-L-threonyl-[myosin light chain]; Xref=Rhea:RHEA:53900, Rhea:RHEA-COMP:13686, Rhea:RHEA-COMP:13687, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.18; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Kinetic parameters: KM=4.3 uM for MYL2 ; Vmax=0.26 umol/min/mg enzyme ; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UIZ8-1; Sequence=Displayed; Name=2; IsoId=Q3UIZ8-2; Sequence=VSP_022369, VSP_022370; Restricted to cardiomyocytes (at protein level). Down-regulated in heart after experimental myocardial infarction at the protein level; no significant changes at the mRNA level. Up-regulated in the heart from 10.5 dpc to neonates and further increased in adults. Down-regulated in aged hearts (at protein level). Phosphorylated on serine residues. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding regulation of vascular permeability involved in acute inflammatory response protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity myosin light chain kinase activity ATP binding cytoplasm cytosol protein phosphorylation kinase activity phosphorylation transferase activity sarcomere organization sarcomerogenesis cardiac myofibril assembly positive regulation of sarcomere organization cellular response to interleukin-1 actin cytoskeleton uc009mps.1 uc009mps.2 uc009mps.3 
ENSMUST00000034136.12 Gpt2 ENSMUST00000034136.12 glutamic pyruvate transaminase (alanine aminotransferase) 2 (from RefSeq NM_173866.4) ALAT2_MOUSE Aat2 ENSMUST00000034136.1 ENSMUST00000034136.10 ENSMUST00000034136.11 ENSMUST00000034136.2 ENSMUST00000034136.3 ENSMUST00000034136.4 ENSMUST00000034136.5 ENSMUST00000034136.6 ENSMUST00000034136.7 ENSMUST00000034136.8 ENSMUST00000034136.9 NM_173866 Q8BGT5 Q8BVY7 Q8K1J3 uc009mpy.1 uc009mpy.2 uc009mpy.3 Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Reaction=2-oxoglutarate + L-alanine = L-glutamate + pyruvate; Xref=Rhea:RHEA:19453, ChEBI:CHEBI:15361, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57972; EC=2.6.1.2; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1. Homodimer. Specifically induced in fatty liver. Highly expressed in muscle, liver and white adipose tissue. Moderately expressed in brain and kidney and expressed at low levels in the heart. May be responsible for increased ALT activity in hepatic steatosis. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. catalytic activity L-alanine:2-oxoglutarate aminotransferase activity mitochondrion 2-oxoglutarate metabolic process transaminase activity biosynthetic process transferase activity pyridoxal phosphate binding L-alanine metabolic process L-alanine catabolic process uc009mpy.1 uc009mpy.2 uc009mpy.3 
ENSMUST00000034138.7 Dnaja2 ENSMUST00000034138.7 DnaJ heat shock protein family (Hsp40) member A2 (from RefSeq NM_019794.5) DNJA2_MOUSE ENSMUST00000034138.1 ENSMUST00000034138.2 ENSMUST00000034138.3 ENSMUST00000034138.4 ENSMUST00000034138.5 ENSMUST00000034138.6 NM_019794 Q9QYJ0 uc009mqa.1 uc009mqa.2 uc009mqa.3 Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Membrane ; Lipid-anchor ATPase activator activity ATP binding nucleus cytosol protein folding response to heat membrane heat shock protein binding positive regulation of ATPase activity protein refolding metal ion binding unfolded protein binding chaperone binding uc009mqa.1 uc009mqa.2 uc009mqa.3 
ENSMUST00000034140.9 Itfg1 ENSMUST00000034140.9 integrin alpha FG-GAP repeat containing 1 (from RefSeq NM_028007.3) D8Wsu49e E9QQ11 ENSMUST00000034140.1 ENSMUST00000034140.2 ENSMUST00000034140.3 ENSMUST00000034140.4 ENSMUST00000034140.5 ENSMUST00000034140.6 ENSMUST00000034140.7 ENSMUST00000034140.8 Itfg1 Lnkn-1 NM_028007 Q99KW9 Q9D6X1 TIP_MOUSE Tip uc009mqf.1 uc009mqf.2 uc009mqf.3 uc009mqf.4 Modulator of T-cell function. Has a protective effect in graft versus host disease model. Interacts with RUVBL1, RUVBL2 and alpha-tubulin. Secreted Membrane ; Single-pass type I membrane protein Belongs to the TIP family. protein binding extracellular region biological_process membrane integral component of membrane uc009mqf.1 uc009mqf.2 uc009mqf.3 uc009mqf.4 
ENSMUST00000034141.18 Lonp2 ENSMUST00000034141.18 lon peptidase 2, peroxisomal, transcript variant 1 (from RefSeq NM_025827.3) ENSMUST00000034141.1 ENSMUST00000034141.10 ENSMUST00000034141.11 ENSMUST00000034141.12 ENSMUST00000034141.13 ENSMUST00000034141.14 ENSMUST00000034141.15 ENSMUST00000034141.16 ENSMUST00000034141.17 ENSMUST00000034141.2 ENSMUST00000034141.3 ENSMUST00000034141.4 ENSMUST00000034141.5 ENSMUST00000034141.6 ENSMUST00000034141.7 ENSMUST00000034141.8 ENSMUST00000034141.9 LONP2_MOUSE NM_025827 Q3TEG8 Q3TFY6 Q3TGR0 Q3UAE1 Q9DBN5 uc009mqm.1 uc009mqm.2 uc009mqm.3 uc009mqm.4 uc009mqm.5 uc009mqm.6 ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53; Evidence=; Interacts with PEX5. Interacts with TYSND1 (By similarity). May interact with enzymes involved in beta-oxidation of fatty acids, including ACOX1/AOX (By similarity). Peroxisome matrix Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DBN5-1; Sequence=Displayed; Name=2; IsoId=Q9DBN5-2; Sequence=VSP_025577, VSP_025578; Name=3; IsoId=Q9DBN5-3; Sequence=VSP_025576; Belongs to the peptidase S16 family. nucleotide binding protease binding ATP-dependent peptidase activity serine-type endopeptidase activity protein binding ATP binding nucleus cytoplasm peroxisome peroxisomal matrix proteolysis misfolded or incompletely synthesized protein catabolic process protein targeting to peroxisome peptidase activity serine-type peptidase activity response to organic cyclic compound protein processing protein import into peroxisome matrix hydrolase activity ATPase activity enzyme binding protein catabolic process regulation of fatty acid beta-oxidation uc009mqm.1 uc009mqm.2 uc009mqm.3 uc009mqm.4 uc009mqm.5 uc009mqm.6 
ENSMUST00000034146.5 Ucp1 ENSMUST00000034146.5 uncoupling protein 1 (mitochondrial, proton carrier) (from RefSeq NM_009463.3) ENSMUST00000034146.1 ENSMUST00000034146.2 ENSMUST00000034146.3 ENSMUST00000034146.4 NM_009463 P12242 Slc25a7 UCP1_MOUSE Ucp Ucp1 uc009mjx.1 uc009mjx.2 uc009mjx.3 uc009mjx.4 Mitochondrial transporter that functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP (PubMed:23063128). Responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (PubMed:9139827, PubMed:19187776, PubMed:23063128, PubMed:27027295). Regulates the production of reactive oxygen species/ROS by mitochondria (PubMed:20416274, PubMed:20466728). Reaction=H(+)(in) = H(+)(out); Xref=Rhea:RHEA:34979, ChEBI:CHEBI:15378; Evidence=; Has no constitutive proton transporter activity and has to be activated by long-chain fatty acids/LCFAs. Inhibited by purine nucleotides. Both purine nucleotides and LCFAs bind the cytosolic side of the transporter and directly compete to activate or inhibit it (PubMed:23063128). Activated by noradrenaline and reactive oxygen species (PubMed:27027295). Despite lacking canonical translational encoding for selenocysteine, a small pool of the protein has been observed to selectively incorporate selenocysteine at 'Cys- 254' (PubMed:32358195). Selenocysteine-modified protein is highly sensitive to redox modification and may constitute a pool of protein highly sensitive to activation by elevated levels of reactive oxygen species (ROS) (PubMed:32358195). Most probably functions as a monomer. Binds one purine nucleotide per monomer. However, has also been suggested to function as a homodimer or a homotetramer. Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity. Mitochondrion inner membrane ; Multi-pass membrane protein Expressed in brown adipose tissue. Up-regulated in response to cold in brown adipose tissue where it may regulate non-shivering thermogenesis (at protein level) (PubMed:20466728, PubMed:25578880). Up-regulated by high-fat diet (at protein level) (PubMed:19187776). Sulfenylation at Cys-254 is increased upon cold exposure. It increases the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects. May undergo ubiquitin-mediated proteasomal degradation. Mice lacking Ucp1 display an absence of adaptive thermogenesis in response to cold. Compared to wild-type mice, they are sensitive to cold and consume less oxygen upon treatment with beta-3- adrenergic-receptor agonists that normally activate thermogenesis (PubMed:9139827, PubMed:19187776). They also display impaired adaptive thermogenesis in response to diet variation (PubMed:19187776). If they display lipid accumulation in adipocytes of brown adipose tissues, no overt obesity is observed when mice are housed under classical conditions, i.e. 18 to 20 degrees Celsius (PubMed:9139827). However, when mice are housed at thermoneutrality, i.e. at 30 degrees Celsius, obesity is clearly observed and exacerbated by high fat diet (PubMed:19187776). The brown adipose tissue of mice lacking Ucp1 produce higher levels of reactive oxygen species (PubMed:20416274, PubMed:20466728). Belongs to the mitochondrial carrier (TC 2.A.29) family. diet induced thermogenesis protein binding GTP binding mitochondrion mitochondrial envelope mitochondrial inner membrane regulation of transcription from RNA polymerase II promoter ion transport mitochondrial transport response to temperature stimulus response to cold membrane integral component of membrane oxidative phosphorylation uncoupler activity GDP binding transmembrane transporter activity response to nutrient levels mitochondrial membrane purine ribonucleotide binding cellular response to hormone stimulus cellular response to reactive oxygen species long-chain fatty acid binding brown fat cell differentiation cellular response to fatty acid cardiolipin binding hydrogen ion transmembrane transport regulation of reactive oxygen species biosynthetic process mitochondrial transmembrane transport adaptive thermogenesis uc009mjx.1 uc009mjx.2 uc009mjx.3 uc009mjx.4 
ENSMUST00000034147.4 Zfp330 ENSMUST00000034147.4 zinc finger protein 330, transcript variant 1 (from RefSeq NM_145600.2) ENSMUST00000034147.1 ENSMUST00000034147.2 ENSMUST00000034147.3 NM_145600 Noa36 Q8C389 Q8K2M4 Q922H9 ZN330_MOUSE Znf330 uc009mjp.1 uc009mjp.2 uc009mjp.3 Nucleus Nucleus, nucleolus Chromosome, centromere Note=Predominantly expressed in nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q922H9-1; Sequence=Displayed; Name=2; IsoId=Q922H9-2; Sequence=VSP_011428; Belongs to the NOA36 family. chromosome, centromeric region nucleus chromosome nucleolus biological_process zinc ion binding midbody metal ion binding uc009mjp.1 uc009mjp.2 uc009mjp.3 
ENSMUST00000034148.7 Il15 ENSMUST00000034148.7 Secreted (from UniProt Q3U1Z6) AK155616 ENSMUST00000034148.1 ENSMUST00000034148.2 ENSMUST00000034148.3 ENSMUST00000034148.4 ENSMUST00000034148.5 ENSMUST00000034148.6 Il15 Q3U1Z6 Q3U1Z6_MOUSE uc009mjk.1 uc009mjk.2 uc009mjk.3 uc009mjk.4 Secreted Belongs to the IL-15/IL-21 family. cytokine activity cytokine receptor binding extracellular region extracellular space nucleoplasm cytosol inflammatory response immune response tyrosine phosphorylation of STAT protein aging positive regulation of cell proliferation cell surface skeletal muscle atrophy nuclear speck hyaluronan metabolic process macrophage differentiation response to nutrient levels positive regulation of interleukin-17 production interleukin-15-mediated signaling pathway neutrophil activation positive regulation of tyrosine phosphorylation of STAT protein negative regulation of smooth muscle cell proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis cellular response to vitamin D uc009mjk.1 uc009mjk.2 uc009mjk.3 uc009mjk.4 
ENSMUST00000034159.8 Txnl4b ENSMUST00000034159.8 thioredoxin-like 4B (from RefSeq NM_175646.4) ENSMUST00000034159.1 ENSMUST00000034159.2 ENSMUST00000034159.3 ENSMUST00000034159.4 ENSMUST00000034159.5 ENSMUST00000034159.6 ENSMUST00000034159.7 NM_175646 Q52KF0 Q8BUH1 TXN4B_MOUSE uc012gkh.1 uc012gkh.2 uc012gkh.3 Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition (By similarity). Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome (By similarity). Nucleus Belongs to the DIM1 family. mRNA splicing, via spliceosome molecular_function nucleus nucleoplasm U5 snRNP cytosol mRNA processing cell cycle positive regulation of cell proliferation RNA splicing U4/U6 x U5 tri-snRNP complex uc012gkh.1 uc012gkh.2 uc012gkh.3 
ENSMUST00000034162.8 Pmfbp1 ENSMUST00000034162.8 polyamine modulated factor 1 binding protein 1 (from RefSeq NM_019938.3) ENSMUST00000034162.1 ENSMUST00000034162.2 ENSMUST00000034162.3 ENSMUST00000034162.4 ENSMUST00000034162.5 ENSMUST00000034162.6 ENSMUST00000034162.7 NM_019938 PMFBP_MOUSE Q9WVQ0 Stap uc009nii.1 uc009nii.2 uc009nii.3 uc009nii.4 Required for normal spermatogenesis (PubMed:30032984, PubMed:30298696). It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity (PubMed:30032984). May also be involved in the general organization of cellular cytoskeleton. Cell projection, cilium, flagellum te=Localized at the sperm head-tail connecting piece (PubMed:30032984, PubMed:30298696). During spermatogenesis, it is first observed in the cytoplasm of round spermatids, it later appears in the implantation fossa region of the sperm nucleus during sperm head elongation and differentiation, and finally it localizes to the head-tail connecting piece (PubMed:30032984). Expressed in the testis. Knockout male mice are infertile and have acephalic spermatozoa, while females are fertile and show normal follicle development. molecular_function cytoplasm cilium spermatogenesis motile cilium cell projection sperm connecting piece uc009nii.1 uc009nii.2 uc009nii.3 uc009nii.4 
ENSMUST00000034163.9 Zfp821 ENSMUST00000034163.9 zinc finger protein 821, transcript variant 8 (from RefSeq NM_001363383.1) E9Q0F1 ENSMUST00000034163.1 ENSMUST00000034163.2 ENSMUST00000034163.3 ENSMUST00000034163.4 ENSMUST00000034163.5 ENSMUST00000034163.6 ENSMUST00000034163.7 ENSMUST00000034163.8 NM_001363383 Q3UWR1 Q6PD05 ZN821_MOUSE Znf821 uc009njc.1 uc009njc.2 uc009njc.3 uc009njc.4 uc009njc.5 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc009njc.1 uc009njc.2 uc009njc.3 uc009njc.4 uc009njc.5 
ENSMUST00000034164.6 Ist1 ENSMUST00000034164.6 increased sodium tolerance 1 homolog (yeast), transcript variant 1 (from RefSeq NM_028018.2) ENSMUST00000034164.1 ENSMUST00000034164.2 ENSMUST00000034164.3 ENSMUST00000034164.4 ENSMUST00000034164.5 IST1_MOUSE Kiaa0174 NM_028018 Q80U68 Q9CX00 uc009niz.1 uc009niz.2 uc009niz.3 uc009niz.4 ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (By similarity). Is required for efficient abscission during cytokinesis (By similarity). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (By similarity). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (By similarity). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (By similarity). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (By similarity). Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4. Interacts with SPART (via MIT domain); leading to the recruitment of SPART to midbodies. Interacts with SPAST. Cytoplasmic vesicle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody Nucleus envelope Note=Localizes to centrosome and midbody of dividing cells. Colocalized with SPART to the ends of Flemming bodies during cytokinesis. Localizes to the reforming nuclear envelope on chromatin disks during late anaphase. Belongs to the IST1 family. chromatin protein binding nucleus nuclear envelope cytoplasm endoplasmic reticulum-Golgi intermediate compartment centrosome microtubule organizing center cytosol cytoskeleton cell cycle protein localization abscission protein transport viral release from host cell protein domain specific binding midbody cytoplasmic vesicle identical protein binding intracellular membrane-bounded organelle macromolecular complex binding establishment of protein localization positive regulation of proteolysis viral capsid secondary envelopment positive regulation of collateral sprouting cell division cytoskeleton-dependent cytokinesis extracellular exosome MIT domain binding Flemming body uc009niz.1 uc009niz.2 uc009niz.3 uc009niz.4 
ENSMUST00000034171.9 Ap1g1 ENSMUST00000034171.9 adaptor protein complex AP-1, gamma 1 subunit, transcript variant 2 (from RefSeq NM_001301211.1) AP1G1_MOUSE Adtg Clapg1 ENSMUST00000034171.1 ENSMUST00000034171.2 ENSMUST00000034171.3 ENSMUST00000034171.4 ENSMUST00000034171.5 ENSMUST00000034171.6 ENSMUST00000034171.7 ENSMUST00000034171.8 NM_001301211 P22892 uc012gkl.1 uc012gkl.2 uc012gkl.3 uc012gkl.4 uc012gkl.5 uc012gkl.6 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity). Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3) (By similarity). Interacts (via GAE domain) with RABEP1 (By similarity). Interacts with EPS15 (PubMed:12176391). Interacts with SYNRG/gamma-synergin (PubMed:12176391). Interacts (via GAE domain) with AP1AR (via coiled- coil domain) (By similarity). Interacts with CLN3 (via dileucine motif); this interaction facilitates lysosomal targeting (By similarity). Interacts (via GAE domain) with AFTPH/aftiphilin; the interaction is required to recruit AFTPH/aftiphilin to the perinuclear region of the cell (By similarity). P22892; P35585: Ap1m1; NbExp=6; IntAct=EBI-1040262, EBI-1040251; P22892; Q14677: CLINT1; Xeno; NbExp=10; IntAct=EBI-1040262, EBI-1171113; Golgi apparatus Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm Cytoplasm, perinuclear region Cytoplasmic vesicle, clathrin-coated vesicle Membrane, clathrin-coated pit Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (By similarity). Co-localizes with AFTPH/aftiphilin in the cytoplasm (By similarity). Widely expressed. Belongs to the adaptor complexes large subunit family. microtubule cytoskeleton organization protein binding collagen binding Golgi apparatus trans-Golgi network cytosol intracellular protein transport protein C-terminus binding protein transport microtubule cytoskeleton membrane vesicle-mediated transport Rab GTPase binding kinesin binding membrane coat AP-1 adaptor complex clathrin-coated vesicle clathrin-coated vesicle membrane GTP-dependent protein binding cytoplasmic vesicle endosome to melanosome transport intracellular membrane-bounded organelle positive regulation of natural killer cell degranulation positive regulation of natural killer cell mediated cytotoxicity perinuclear region of cytoplasm recycling endosome Golgi to lysosome transport uc012gkl.1 uc012gkl.2 uc012gkl.3 uc012gkl.4 uc012gkl.5 uc012gkl.6 
ENSMUST00000034172.8 Ces1d ENSMUST00000034172.8 carboxylesterase 1D (from RefSeq NM_053200.2) Ces1 Ces1d Ces3 ENSMUST00000034172.1 ENSMUST00000034172.2 ENSMUST00000034172.3 ENSMUST00000034172.4 ENSMUST00000034172.5 ENSMUST00000034172.6 ENSMUST00000034172.7 EST1D_MOUSE NM_053200 Q8VCT4 Q91ZV9 Q924V8 Q9ULY1 uc009mun.1 uc009mun.2 uc009mun.3 Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters (PubMed:15220344). Hydrolyzes retinyl esters (By similarity). Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence= Reaction=a long-chain fatty acyl ethyl ester + H2O = a long-chain fatty acid + ethanol + H(+); Xref=Rhea:RHEA:16641, ChEBI:CHEBI:13209, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16236, ChEBI:CHEBI:57560; EC=3.1.1.67; Evidence=; Reaction=all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate; Xref=Rhea:RHEA:13933, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13934; Evidence=; Homotrimer. Endoplasmic reticulum lumen Cytoplasm, cytosol Lipid droplet Microsome Highest expression occurs in liver with lower levels in adipose tissue, kidney, heart, intestine, lung, testis and thymus. By di-(2-ethylhexyl) phthalate. Belongs to the type-B carboxylesterase/lipase family. Was originally thought to originate from human. sterol esterase activity triglyceride lipase activity extracellular space cytoplasm endoplasmic reticulum endoplasmic reticulum lumen lipid particle cytosol lipid metabolic process acyl-CoA metabolic process cholesterol biosynthetic process response to toxic substance lipid catabolic process hydrolase activity short-chain fatty acid catabolic process fatty-acyl-ethyl-ester synthase activity epithelial cell differentiation very-low-density lipoprotein particle assembly acylglycerol catabolic process medium-chain fatty acid metabolic process carboxylic ester hydrolase activity methyl indole-3-acetate esterase activity uc009mun.1 uc009mun.2 uc009mun.3 
ENSMUST00000034173.14 Ces1e ENSMUST00000034173.14 carboxylesterase 1E, transcript variant 1 (from RefSeq NM_133660.4) Ces1e ENSMUST00000034173.1 ENSMUST00000034173.10 ENSMUST00000034173.11 ENSMUST00000034173.12 ENSMUST00000034173.13 ENSMUST00000034173.2 ENSMUST00000034173.3 ENSMUST00000034173.4 ENSMUST00000034173.5 ENSMUST00000034173.6 ENSMUST00000034173.7 ENSMUST00000034173.8 ENSMUST00000034173.9 EST1E_MOUSE Es22 NM_133660 Q64176 uc009muo.1 uc009muo.2 uc009muo.3 Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes retinyl esters. Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence=; Reaction=all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate; Xref=Rhea:RHEA:13933, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13934; Evidence=; Endoplasmic reticulum lumen Microsome membrane Belongs to the type-B carboxylesterase/lipase family. sterol esterase activity triglyceride lipase activity extracellular space endoplasmic reticulum endoplasmic reticulum lumen lipid catabolic process palmitoyl-CoA hydrolase activity hydrolase activity carboxylic ester hydrolase activity methyl indole-3-acetate esterase activity uc009muo.1 uc009muo.2 uc009muo.3 
ENSMUST00000034178.9 Ces1f ENSMUST00000034178.9 carboxylesterase 1F (from RefSeq NM_144930.2) Ces1f CesML1 D6RHA4 ENSMUST00000034178.1 ENSMUST00000034178.2 ENSMUST00000034178.3 ENSMUST00000034178.4 ENSMUST00000034178.5 ENSMUST00000034178.6 ENSMUST00000034178.7 ENSMUST00000034178.8 EST1F_MOUSE NM_144930 Q3UWB1 Q91WU0 uc009mup.1 uc009mup.2 uc009mup.3 uc009mup.4 Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes retinyl esters (By similarity). Hydrolyzes p-nitrophenyl butyrate (PNPB), triacylglycerol and monoacylglycerol. Shows higher activity against PNPB, a short-chain fatty acid ester, than against triolein, a long-chain fatty acid ester. Shows no detectable activity against diacylglycerol, cholesterol ester or phospholipids. May play a role in adipocyte lipolysis. Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence= Reaction=all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate; Xref=Rhea:RHEA:13933, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13934; Evidence=; Lipid droplet Cytoplasm, cytosol Endoplasmic reticulum Microsome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91WU0-1; Sequence=Displayed; Name=2; IsoId=Q91WU0-2; Sequence=VSP_058396, VSP_058397; Expressed in liver, white and brown adipose tissue, kidney, intestine, adrenal, heart and ovary. Not detected in muscle, lung, testis, brain and spleen. Induced by fasting and repressed by refeeding. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the type-B carboxylesterase/lipase family. sterol esterase activity triglyceride lipase activity extracellular space cytoplasm endoplasmic reticulum lipid particle cytosol lipid catabolic process hydrolase activity short-chain fatty acid catabolic process carboxylic ester hydrolase activity methyl indole-3-acetate esterase activity uc009mup.1 uc009mup.2 uc009mup.3 uc009mup.4 
ENSMUST00000034184.12 Irx5 ENSMUST00000034184.12 Iroquois homeobox 5 (from RefSeq NM_018826.2) ENSMUST00000034184.1 ENSMUST00000034184.10 ENSMUST00000034184.11 ENSMUST00000034184.2 ENSMUST00000034184.3 ENSMUST00000034184.4 ENSMUST00000034184.5 ENSMUST00000034184.6 ENSMUST00000034184.7 ENSMUST00000034184.8 ENSMUST00000034184.9 IRX5_MOUSE Irxb2 NM_018826 Q80WV4 Q9JKQ4 Q9JLL5 uc009mub.1 uc009mub.2 uc009mub.3 Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina. Involved in craniofacial and gonadal development (By similarity). Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. Nucleus Not expressed in the developing metanephric kidney or adult kidney. In 9.5 dpc embryos, expressed in the rhombencephalon, metencephalon, and in the cephalic mesoderm surround the optic vesicle. By 12.5 dpc, expression continues in the mesenchyme and also begins in subsets of cells in the neuroretina, becoming expressed in the retinal inner neuroblast layers by 16.5 dpc. Expressed in developing bipolar cells during retinal development starting at postnatal day 5, and expressed in a subset of cone bipolar cells in the mature retina. Also expressed along the spinal cord, in the ventricular layer, in motor neurons and in the proximal limb buds during embryonic development. Expressed in the developing heart in the endocardium that lines the heart chambers. Disruption causes increased KCND2 potassium- channel expression in endocardial myocardium leading to abolition of the cardiac repolarization gradient, a selective increase of the major cardiac repolarization current, I(to,f), and increased susceptibility to arrhythmias. Belongs to the TALE/IRO homeobox family. Sequence=AAF63955.1; Type=Frameshift; Evidence=; regulation of heart rate DNA binding nucleus regulation of transcription, DNA-templated visual perception gonad development regulation of gene expression neuron maturation sequence-specific DNA binding cell development embryonic cranial skeleton morphogenesis response to stimulus retinal bipolar neuron differentiation uc009mub.1 uc009mub.2 uc009mub.3 
ENSMUST00000034185.13 Irx6 ENSMUST00000034185.13 Iroquois homeobox 6, transcript variant 1 (from RefSeq NM_022428.3) ENSMUST00000034185.1 ENSMUST00000034185.10 ENSMUST00000034185.11 ENSMUST00000034185.12 ENSMUST00000034185.2 ENSMUST00000034185.3 ENSMUST00000034185.4 ENSMUST00000034185.5 ENSMUST00000034185.6 ENSMUST00000034185.7 ENSMUST00000034185.8 ENSMUST00000034185.9 Irx6 NM_022428 Q8BFT1 Q8BFT1_MOUSE uc009mud.1 uc009mud.2 uc009mud.3 uc009mud.4 Nucleus Belongs to the TALE/IRO homeobox family. DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc009mud.1 uc009mud.2 uc009mud.3 uc009mud.4 
ENSMUST00000034187.9 Mmp2 ENSMUST00000034187.9 matrix metallopeptidase 2 (from RefSeq NM_008610.3) ENSMUST00000034187.1 ENSMUST00000034187.2 ENSMUST00000034187.3 ENSMUST00000034187.4 ENSMUST00000034187.5 ENSMUST00000034187.6 ENSMUST00000034187.7 ENSMUST00000034187.8 Mmp2 NM_008610 Q3UG07 Q3UG07_MOUSE uc009mue.1 uc009mue.2 uc009mue.3 uc009mue.4 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that hydrolyzes collagens, gelatins, laminin, fibronectin and elastin. Mice lacking the encoded protein exhibit suppressed angiogenesis and attenuated features of human multicentric osteolysis with arthritis including abnormal skeletal and craniofacial development. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070430.1, AK148184.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Reaction=Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.; EC=3.4.24.24; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Can bind about 5 Ca(2+) ions per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. Interacts (via the C-terminal hemopexin-like domains- containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C- terminal); the interaction inhibits the degradation activity. Interacts with GSK3B. Secreted, extracellular space, extracellular matrix Belongs to the peptidase M10A family. metalloendopeptidase activity extracellular space proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity extracellular matrix endodermal cell differentiation metal ion binding positive regulation of vascular smooth muscle cell proliferation uc009mue.1 uc009mue.2 uc009mue.3 uc009mue.4 
ENSMUST00000034189.17 Ces1c ENSMUST00000034189.17 carboxylesterase 1C (from RefSeq NM_007954.4) E9QQ07 ENSMUST00000034189.1 ENSMUST00000034189.10 ENSMUST00000034189.11 ENSMUST00000034189.12 ENSMUST00000034189.13 ENSMUST00000034189.14 ENSMUST00000034189.15 ENSMUST00000034189.16 ENSMUST00000034189.2 ENSMUST00000034189.3 ENSMUST00000034189.4 ENSMUST00000034189.5 ENSMUST00000034189.6 ENSMUST00000034189.7 ENSMUST00000034189.8 ENSMUST00000034189.9 EST1C_MOUSE Es1 NM_007954 O54936 P11374 P23953 Q8K125 uc009mul.1 uc009mul.2 uc009mul.3 uc009mul.4 uc009mul.5 Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant. Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence=; Endoplasmic reticulum lumen. Note=Microsomal membrane, lumen of endoplasmic reticulum. Expressed in lung, kidney and liver. Belongs to the type-B carboxylesterase/lipase family. Sequence=AAA37579.1; Type=Frameshift; Evidence=; Sequence=AAA37579.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence=; sterol esterase activity triglyceride lipase activity extracellular space endoplasmic reticulum endoplasmic reticulum lumen response to bacterium lipid catabolic process hydrolase activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity methyl indole-3-acetate esterase activity uc009mul.1 uc009mul.2 uc009mul.3 uc009mul.4 uc009mul.5 
ENSMUST00000034190.11 Vac14 ENSMUST00000034190.11 Vac14 homolog (S. cerevisiae), transcript variant 3 (from RefSeq NR_151675.1) D8Wsu151e ENSMUST00000034190.1 ENSMUST00000034190.10 ENSMUST00000034190.2 ENSMUST00000034190.3 ENSMUST00000034190.4 ENSMUST00000034190.5 ENSMUST00000034190.6 ENSMUST00000034190.7 ENSMUST00000034190.8 ENSMUST00000034190.9 NR_151675 Q3TAX7 Q80WQ2 Q8C8K8 VAC14_MOUSE uc009nkv.1 uc009nkv.2 uc009nkv.3 uc009nkv.4 Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3- phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. Forms pentamers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities. Interacts with NOS1. Endosome membrane Microsome membrane Note=Mainly associated with membranes of the late endocytic pathway. Ubiquitous. The C-terminal domain (residues 523-782) mediates pentameric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex. Note=Defects in Vac14 are the cause of the infantile gliosis phenotype (ingls). Mice exhibit reduced body size and diluted pigmentation that can be recognized as early as postnatal day 3 (P3). By P14, the mice exhibit a tremor and impaired motor function. Maximal survival of the mice is for 3 weeks. Small areas with the appearance of spongiform degeneration are visible in several brain regions, including the thalamus, brain stem and cerebellar nucleus. Mice die perinatally and exhibit profound degeneration in certain regions of the central and peripheral nervous systems. Selected regions in the brain are affected, especially the medulla, the pons and the midbrain and increased cell death occurs in these areas. Affected neurons contain large vacuoles. Belongs to the VAC14 family. extrinsic component of vacuolar membrane endosome vacuolar membrane endoplasmic reticulum phosphatidylinositol biosynthetic process response to osmotic stress endosome membrane membrane kinase activator activity organelle membrane positive regulation of kinase activity intracellular membrane-bounded organelle PAS complex uc009nkv.1 uc009nkv.2 uc009nkv.3 uc009nkv.4 
ENSMUST00000034197.5 St3gal2 ENSMUST00000034197.5 ST3 beta-galactoside alpha-2,3-sialyltransferase 2, transcript variant 1 (from RefSeq NM_009179.4) ENSMUST00000034197.1 ENSMUST00000034197.2 ENSMUST00000034197.3 ENSMUST00000034197.4 NM_009179 Q11204 Q8BPL0 SIA4B_MOUSE Siat4b Siat5 St3gal2 uc009nlk.1 uc009nlk.2 uc009nlk.3 uc009nlk.4 A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8144500, PubMed:9184827). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8144500, PubMed:9184827). Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (PubMed:22735313). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (PubMed:32030804). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell- associated antigen SSEA3, forming SSEA4 (By similarity). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:8144500). Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha- neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:21616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133470, ChEBI:CHEBI:139596; EC=2.4.3.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21617; Evidence=; Reaction=a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:18021, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:77709, ChEBI:CHEBI:78445; EC=2.4.3.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18022; Evidence=; Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) = CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+); Xref=Rhea:RHEA:48248, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:73110, ChEBI:CHEBI:90153; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48249; Evidence=; Reaction=a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b + CMP + H(+); Xref=Rhea:RHEA:48244, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:88069, ChEBI:CHEBI:90151; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48245; Evidence=; Reaction=a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:47560, ChEBI:CHEBI:15378, ChEBI:CHEBI:27938, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47561; Evidence=; Reaction=a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1b + CMP + H(+); Xref=Rhea:RHEA:48240, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:82939, ChEBI:CHEBI:82940; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48241; Evidence=; Reaction=a ganglioside GD1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1b (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:47572, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78452, ChEBI:CHEBI:87785; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47573; Evidence=; Reaction=a globoside GalGb4Cer + CMP-N-acetyl-beta-neuraminate = a globoside MSGG + CMP + H(+); Xref=Rhea:RHEA:65372, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:140623, ChEBI:CHEBI:140691; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65373; Evidence=; Kinetic parameters: KM=2.3 mM for Gal-beta-1,3-GlcNAc ; KM=0.16 mM for Gal-beta-1,3-GalNAc ; KM=0.63 mM for Gal-beta-1,3-GalNAc ; KM=0.83 mM for GM1 ; KM=0.67 mM for asialo-GM1 ; Note=Vmax is 10 fold higher with Gal-beta-1,3-GalNAc than with Gal- beta-1,3-GlcNAc as substrate. ; pH dependence: Optimum pH is 6.4. ; Protein modification; protein glycosylation. Glycolipid biosynthesis. Homodimer; disulfide-linked. Homodimer formation occurs in the endoplasmic reticulum. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form distributed along the Golgi cisternae, mainly in proximal compartments (By similarity). Secreted into the body fluid. Strongly expressed in brain and liver and to a lesser extent in heart and kidney. Scarcely detectable in lung, pancreas, spleen and submaxillary gland (PubMed:8144500). Expressed in L5 dorsal root ganglion (DRG) neurons (at protein level) (PubMed:32030804). Up-regulated in DRG neurons in response to nerve injury. The soluble form derives from the membrane form by proteolytic processing. N-glycosylated; necessary for proper exit from endoplasmic reticulum and trafficking to the Golgi apparatus. No visible phenotype under physiological conditions; due to the redundancy with ST3GAL3. Simultaneous knockdown of ST3GAL2 and ST3GAL3 results in markedly fewer offspring and impaired nervous system function at weaning (PubMed:22735313). Knockout mice show reduced nerve injury-induced neuropathic pain in response to noxious stimuli (hyperalgesia) and to normally innocuous stimuli (allodynia) (PubMed:32030804). Belongs to the glycosyltransferase 29 family. Name=Functional Glycomics Gateway - GTase; Note=ST3Gal II; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_643"; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity extracellular region Golgi apparatus protein glycosylation sialyltransferase activity glycoprotein biosynthetic process glycolipid biosynthetic process oligosaccharide biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups lipid glycosylation Golgi cisterna membrane monosialoganglioside sialyltransferase activity sialylation protein sialylation uc009nlk.1 uc009nlk.2 uc009nlk.3 uc009nlk.4 
ENSMUST00000034198.15 Gnao1 ENSMUST00000034198.15 guanine nucleotide binding protein, alpha O, transcript variant A (from RefSeq NM_010308.4) ENSMUST00000034198.1 ENSMUST00000034198.10 ENSMUST00000034198.11 ENSMUST00000034198.12 ENSMUST00000034198.13 ENSMUST00000034198.14 ENSMUST00000034198.2 ENSMUST00000034198.3 ENSMUST00000034198.4 ENSMUST00000034198.5 ENSMUST00000034198.6 ENSMUST00000034198.7 ENSMUST00000034198.8 ENSMUST00000034198.9 Gnao1 NM_010308 Q543S2 Q543S2_MOUSE uc009mvm.1 uc009mvm.2 Belongs to the G-alpha family. G(i/o/t/z) subfamily. nucleotide binding GTPase activity GTP binding signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway guanyl nucleotide binding G-protein beta/gamma-subunit complex binding metal ion binding uc009mvm.1 uc009mvm.2 
ENSMUST00000034203.17 Cog4 ENSMUST00000034203.17 component of oligomeric golgi complex 4, transcript variant 1 (from RefSeq NM_133973.2) COG4_MOUSE ENSMUST00000034203.1 ENSMUST00000034203.10 ENSMUST00000034203.11 ENSMUST00000034203.12 ENSMUST00000034203.13 ENSMUST00000034203.14 ENSMUST00000034203.15 ENSMUST00000034203.16 ENSMUST00000034203.2 ENSMUST00000034203.3 ENSMUST00000034203.4 ENSMUST00000034203.5 ENSMUST00000034203.6 ENSMUST00000034203.7 ENSMUST00000034203.8 ENSMUST00000034203.9 NM_133973 Q3T9K1 Q8R1U1 uc009nlf.1 uc009nlf.2 uc009nlf.3 Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Monomer. Component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Mediates interaction of SCFD1 with the COG complex. Interacts with STX5. Cytoplasm, cytosol Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the COG4 family. Golgi membrane cytoplasm Golgi apparatus cytosol retrograde vesicle-mediated transport, Golgi to ER Golgi organization protein transport membrane Golgi transport complex identical protein binding Golgi vesicle prefusion complex stabilization uc009nlf.1 uc009nlf.2 uc009nlf.3 
ENSMUST00000034204.11 Nudt21 ENSMUST00000034204.11 nudix hydrolase 21 (from RefSeq NM_026623.3) CPSF5_MOUSE Cpsf5 ENSMUST00000034204.1 ENSMUST00000034204.10 ENSMUST00000034204.2 ENSMUST00000034204.3 ENSMUST00000034204.4 ENSMUST00000034204.5 ENSMUST00000034204.6 ENSMUST00000034204.7 ENSMUST00000034204.8 ENSMUST00000034204.9 NM_026623 Nudt21 Q3UJK1 Q9CQF3 uc009mvo.1 uc009mvo.2 uc009mvo.3 Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA- 3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. NUDT21/CPSF5 activates indirectly the mRNA 3'- processing machinery by recruiting CPSF6 and/or CPSF7. Binds to 5'- UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA (By similarity). Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function(PubMed:29249356). Binds to chromatin (PubMed:18032416). Binds to, but does not hydrolyze mono- and di- adenosine nucleotides (By similarity). Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex which is a heterotetramer composed of two subunits of NUDT21/CPSF5 and two subunits of CPSF6 or CPSF7 or a heterodimer of CPSF6 and CPSF7. The cleavage factor Im (CFIm) complex associates with the CPSF and CSTF complexes to promote the assembly of the core mRNA 3'-processing machinery. Interacts with CPSF6 (via the RRM domain); this interaction is direct and enhances binding to RNA. Interacts with CPSF7. Interacts with FIP1L1; this interaction occurs in a RNA sequence-specific manner. Interacts with PABPN1 (By similarity). Interacts (via N-terminus) with PAPOLA (via C-terminus); this interaction is direct and diminished by acetylation (PubMed:11716503). Interacts with SNRNP70 (By similarity). Interacts with VIRMA (By similarity). Nucleus Cytoplasm Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm). In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles. Expressed in testis (PubMed:18032416). Expressed in male germ cells (at protein level) (PubMed:18032416). Up-regulated during spermatogenesis (PubMed:18032416). Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 and SIRT2. Belongs to the Nudix hydrolase family. CPSF5 subfamily. Lacks the conserved metal-binding residues in the NUDIX motif and is not expected to have hydrolase activity. chromatin binding RNA binding mRNA binding protein binding nucleus cytoplasm centrosome microtubule organizing center mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex mRNA polyadenylation mRNA cleavage mRNA processing posttranscriptional regulation of gene expression nuclear body hydrolase activity cell differentiation positive regulation of mRNA cleavage mRNA 3'-UTR AU-rich region binding paraspeckles identical protein binding protein homodimerization activity histone deacetylase binding protein tetramerization protein heterotetramerization pre-mRNA cleavage required for polyadenylation positive regulation of mRNA polyadenylation messenger ribonucleoprotein complex assembly positive regulation of stem cell differentiation positive regulation of pro-B cell differentiation uc009mvo.1 uc009mvo.2 uc009mvo.3 
ENSMUST00000034205.5 Cenpn ENSMUST00000034205.5 centromere protein N (from RefSeq NM_028131.3) CENPN_MOUSE ENSMUST00000034205.1 ENSMUST00000034205.2 ENSMUST00000034205.3 ENSMUST00000034205.4 NM_028131 Q6PE73 Q8R2W7 Q9CZW2 uc009noo.1 uc009noo.2 Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts directly with CENPA. Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1. Nucleus Chromosome, centromere Chromosome, centromere, kinetochore Note=Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9CZW2-1; Sequence=Displayed; Name=2; IsoId=Q9CZW2-2; Sequence=VSP_020443; Name=3; IsoId=Q9CZW2-3; Sequence=VSP_020444, VSP_020445; Belongs to the CENP-N/CHL4 family. chromosome, centromeric region kinetochore condensed chromosome kinetochore molecular_function nucleus chromosome chromosome segregation kinetochore assembly uc009noo.1 uc009noo.2 
ENSMUST00000034206.6 Bbs2 ENSMUST00000034206.6 Bardet-Biedl syndrome 2 (from RefSeq NM_026116.3) BBS2_MOUSE ENSMUST00000034206.1 ENSMUST00000034206.2 ENSMUST00000034206.3 ENSMUST00000034206.4 ENSMUST00000034206.5 NM_026116 Q9CWF6 uc009mvs.1 uc009mvs.2 uc009mvs.3 The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (By similarity). Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts (via C-terminus) with BBS7. Interacts (via coiled coil domain) with MKKS. Interacts with CCDC28B (By similarity). Interacts with DLEC1 (By similarity). Cell projection, cilium membrane Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite In mice obesity is associated with hyperleptinemia and resistance to the anorectic and weight-reducing effects of leptinan mice are resistant to the metabolic actions of leptin. RNA polymerase II repressing transcription factor binding protein binding cytoplasm microtubule organizing center cytoskeleton plasma membrane microvillus cilium sperm axoneme assembly visual perception protein localization negative regulation of gene expression artery smooth muscle contraction protein transport membrane striatum development hippocampus development cerebral cortex development cell projection organization adult behavior motile cilium stereocilium leptin-mediated signaling pathway protein localization to organelle BBSome ciliary basal body negative regulation of appetite by leptin-mediated signaling pathway negative regulation of multicellular organism growth positive regulation of multicellular organism growth vasodilation cell projection Golgi to plasma membrane protein transport neuron projection response to leptin fat cell differentiation photoreceptor cell maintenance brain morphogenesis cartilage development ciliary membrane cilium assembly regulation of cilium beat frequency involved in ciliary motility protein localization to ciliary membrane non-motile cilium assembly uc009mvs.1 uc009mvs.2 uc009mvs.3 
ENSMUST00000034207.8 Mt4 ENSMUST00000034207.8 metallothionein 4 (from RefSeq NM_008631.3) ENSMUST00000034207.1 ENSMUST00000034207.2 ENSMUST00000034207.3 ENSMUST00000034207.4 ENSMUST00000034207.5 ENSMUST00000034207.6 ENSMUST00000034207.7 Mt4 NM_008631 Q3V2E2 Q3V2E2_MOUSE uc009mvt.1 uc009mvt.2 uc009mvt.3 Metallothioneins have a high content of cysteine residues that bind various heavy metals. Belongs to the metallothionein superfamily. Type 1 family. metal ion binding uc009mvt.1 uc009mvt.2 uc009mvt.3 
ENSMUST00000034211.10 Mt3 ENSMUST00000034211.10 metallothionein 3 (from RefSeq NM_013603.2) ENSMUST00000034211.1 ENSMUST00000034211.2 ENSMUST00000034211.3 ENSMUST00000034211.4 ENSMUST00000034211.5 ENSMUST00000034211.6 ENSMUST00000034211.7 ENSMUST00000034211.8 ENSMUST00000034211.9 Mt3 NM_013603 Q3USP9 Q3USP9_MOUSE uc009mvu.1 uc009mvu.2 uc009mvu.3 uc009mvu.4 Metallothioneins have a high content of cysteine residues that bind various heavy metals. Belongs to the metallothionein superfamily. Type 1 family. response to hypoxia positive regulation of protein phosphorylation copper ion binding extracellular space cytoplasm mitochondrial outer membrane rough endoplasmic reticulum ribosome microtubule plasma membrane apoptotic process brain development synaptic vesicle drug binding zinc ion binding positive regulation of gene expression positive regulation of necrotic cell death positive regulation of cell death postsynaptic density inclusion body histone modification removal of superoxide radicals protein kinase activator activity negative regulation of cell growth axon negative regulation of axon extension positive regulation of vascular endothelial growth factor receptor signaling pathway activation of protein kinase B activity cellular response to oxidative stress cellular response to drug positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process dendritic spine protein kinase B signaling positive regulation of transcription, DNA-templated cadmium ion binding metal ion binding perinuclear region of cytoplasm protein stabilization negative regulation of oxidoreductase activity zinc ion homeostasis cadmium ion homeostasis negative regulation of necrotic cell death ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to cadmium ion cellular response to hypoxia cellular response to nitric oxide astrocyte projection astrocyte end-foot negative regulation of neuron death negative regulation of cysteine-type endopeptidase activity negative regulation of hydrogen peroxide catabolic process negative regulation of reactive oxygen species metabolic process uc009mvu.1 uc009mvu.2 uc009mvu.3 uc009mvu.4 
ENSMUST00000034214.8 Mt2 ENSMUST00000034214.8 metallothionein 2 (from RefSeq NM_008630.2) ENSMUST00000034214.1 ENSMUST00000034214.2 ENSMUST00000034214.3 ENSMUST00000034214.4 ENSMUST00000034214.5 ENSMUST00000034214.6 ENSMUST00000034214.7 MT2_MOUSE NM_008630 P02798 uc009mvv.1 uc009mvv.2 uc009mvv.3 Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. Belongs to the metallothionein superfamily. Type 1 family. nucleus cytoplasm cytosol cellular zinc ion homeostasis nitric oxide mediated signal transduction drug binding zinc ion binding response to bacterium detoxification of copper ion cellular response to drug cellular response to interleukin-3 cellular response to erythropoietin negative regulation of growth metal ion binding perinuclear region of cytoplasm cellular response to cadmium ion cellular response to copper ion cellular response to zinc ion uc009mvv.1 uc009mvv.2 uc009mvv.3 
ENSMUST00000034215.8 Mt1 ENSMUST00000034215.8 metallothionein 1 (from RefSeq NM_013602.3) ENSMUST00000034215.1 ENSMUST00000034215.2 ENSMUST00000034215.3 ENSMUST00000034215.4 ENSMUST00000034215.5 ENSMUST00000034215.6 ENSMUST00000034215.7 MT1_MOUSE NM_013602 P02802 Q64485 uc009mvw.1 uc009mvw.2 uc009mvw.3 uc009mvw.4 Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. Belongs to the metallothionein superfamily. Type 1 family. copper ion binding nucleus cytoplasm lysosome cytosol cellular metal ion homeostasis cellular zinc ion homeostasis nitric oxide mediated signal transduction zinc ion binding detoxification of copper ion negative regulation of neuron apoptotic process negative regulation of growth metal ion binding perinuclear region of cytoplasm cellular response to chromate cellular response to cadmium ion cellular response to copper ion cellular response to zinc ion uc009mvw.1 uc009mvw.2 uc009mvw.3 uc009mvw.4 
ENSMUST00000034218.5 Slc12a3 ENSMUST00000034218.5 solute carrier family 12, member 3, transcript variant 2 (from RefSeq NM_019415.2) ENSMUST00000034218.1 ENSMUST00000034218.2 ENSMUST00000034218.3 ENSMUST00000034218.4 NM_019415 Q543E4 Q543E4_MOUSE Slc12a3 uc009mwf.1 uc009mwf.2 uc009mwf.3 uc009mwf.4 uc009mwf.5 Membrane ; Multi- pass membrane protein Belongs to the SLC12A transporter family. ion transport cation:chloride symporter activity membrane integral component of membrane apical plasma membrane transmembrane transporter activity transmembrane transport extracellular exosome chloride transmembrane transport uc009mwf.1 uc009mwf.2 uc009mwf.3 uc009mwf.4 uc009mwf.5 
ENSMUST00000034225.7 Cntnap4 ENSMUST00000034225.7 contactin associated protein-like 4 (from RefSeq NM_130457.2) CNTP4_MOUSE Caspr4 ENSMUST00000034225.1 ENSMUST00000034225.2 ENSMUST00000034225.3 ENSMUST00000034225.4 ENSMUST00000034225.5 ENSMUST00000034225.6 NM_130457 Q8K002 Q99P47 uc009nnk.1 uc009nnk.2 uc009nnk.3 Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system. Interacts with TIAM1. Presynaptic cell membrane ; Single-pass type I membrane protein Note=Specifically present within the presynaptic compartment of synapses. Specifically present in developing cortical interneurons: highly expressed in cortical parvalbumin (PV) cells and midbrain dopaminergic neurons and is localized presynaptically (at protein level). Also present in the substantia nigra pars compacta (SnC) and ventral tegmental area (VTA) midbrain dopaminergic projection populations. Synaptic defects characterized by increased dopamine but decreased GABA signaling. A reduction in the output of cortical parvalbumin (PV)-positive GABAergic basket cells is observed, together with an increase of midbrain dopaminergic release in the nucleus accumbens. Increased dopaminergic signaling induces behavior abnormalities, characterized by severe and highly penetrant over- grooming behavior, resulting in whisker, face and sometimes body hair loss but rarely lesions. The over-grooming phenotype can be pharmacologically reversed following administration of haloperidol drug. Belongs to the neurexin family. protein binding plasma membrane cell adhesion membrane integral component of membrane cell junction dendrite regulation of synaptic transmission, dopaminergic regulation of synaptic transmission, GABAergic presynaptic membrane synapse regulation of synapse organization GABA-ergic synapse integral component of presynaptic membrane regulation of grooming behavior uc009nnk.1 uc009nnk.2 uc009nnk.3 
ENSMUST00000034226.8 Psme3ip1 ENSMUST00000034226.8 proteasome activator subunit 3 interacting protein 1, transcript variant 4 (from RefSeq NR_156692.1) ENSMUST00000034226.1 ENSMUST00000034226.2 ENSMUST00000034226.3 ENSMUST00000034226.4 ENSMUST00000034226.5 ENSMUST00000034226.6 ENSMUST00000034226.7 Fam192a NR_156692 Nip30 PIP30_MOUSE Psme3ip1 Q3U9X3 Q8R0C9 Q91WE2 uc009mwn.1 uc009mwn.2 uc009mwn.3 uc009mwn.4 uc009mwn.5 Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus. Interacts (via C-terminus) with both free and 20S proteasome- bound forms of the proteasome activator complex subunit PSME3/PA28G; the interaction is direct. Nucleus Expressed in skeletal muscle. Shows relatively constant expression in both proliferating myoblasts and in differentiated myotubes, when assayed in C2C12 cell line (at protein level). Up-regulated in response to denervation-induced skeletal muscle atrophy. Induced by MYOD1. Phosphorylation by CK2 stabilizes the interaction with PSME3. molecular_function nucleus negative regulation of protein binding negative regulation of proteasomal protein catabolic process uc009mwn.1 uc009mwn.2 uc009mwn.3 uc009mwn.4 uc009mwn.5 
ENSMUST00000034227.6 Pllp ENSMUST00000034227.6 plasma membrane proteolipid (from RefSeq NM_026385.4) ENSMUST00000034227.1 ENSMUST00000034227.2 ENSMUST00000034227.3 ENSMUST00000034227.4 ENSMUST00000034227.5 NM_026385 PLLP_MOUSE Plapi Pmlp Q544Q5 Q9DCU2 Tm4sf11 uc009mwv.1 uc009mwv.2 uc009mwv.3 Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). Hexamer arranged as a trimer of two plasmolipin subunits. Membrane; Multi-pass membrane protein. Belongs to the MAL family. ion transport response to wounding membrane integral component of membrane structural constituent of myelin sheath myelination compact myelin membrane raft uc009mwv.1 uc009mwv.2 uc009mwv.3 
ENSMUST00000034228.16 Arl2bp ENSMUST00000034228.16 ADP-ribosylation factor-like 2 binding protein, transcript variant 1 (from RefSeq NM_024191.2) AR2BP_MOUSE Bart Bart1 ENSMUST00000034228.1 ENSMUST00000034228.10 ENSMUST00000034228.11 ENSMUST00000034228.12 ENSMUST00000034228.13 ENSMUST00000034228.14 ENSMUST00000034228.15 ENSMUST00000034228.2 ENSMUST00000034228.3 ENSMUST00000034228.4 ENSMUST00000034228.5 ENSMUST00000034228.6 ENSMUST00000034228.7 ENSMUST00000034228.8 ENSMUST00000034228.9 NM_024191 Q9CQW6 Q9D385 uc009mwt.1 uc009mwt.2 uc009mwt.3 uc009mwt.4 uc009mwt.5 Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity). Interacts with GTP bound ARL2 and ARL3; the complex ARL2- ARL2BP as well as ARL2BP alone, binds to SLC25A4/ANT1. Interaction with ARL2 may be required for targeting to cilia basal body (By similarity). Interacts with STAT3; interaction is enhanced with ARL2. Found in a complex with ARL2BP, ARL2 and SLC25A6 (By similarity). Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4. Cytoplasm Mitochondrion intermembrane space Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Cytoplasm, cytoskeleton, cilium basal body Note=Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules (By similarity). The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria. In retina photoreceptor cells, localized in the distal connecting cilia, basal body, ciliary-associated centriole, and ciliary rootlet. Interaction with ARL2 may be required for cilia basal body localization (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D385-1; Sequence=Displayed; Name=2; IsoId=Q9D385-2; Sequence=VSP_025320, VSP_025319; Widely expressed, with most abundant activity in brain, especially in hippocampus and cortex. Also expressed in lung, cerebellum, liver, kidney, retina, spleen, muscle and heart (at protein level). Belongs to the ARL2BP family. transcription coactivator activity protein binding nucleus cytoplasm mitochondrion mitochondrial intermembrane space centrosome microtubule organizing center cytoskeleton cilium midbody GTPase regulator activity positive regulation of tyrosine phosphorylation of STAT protein cell projection positive regulation of GTPase activity regulation of catalytic activity maintenance of protein location in nucleus positive regulation of nucleic acid-templated transcription GTPase activator activity uc009mwt.1 uc009mwt.2 uc009mwt.3 uc009mwt.4 uc009mwt.5 
ENSMUST00000034230.7 Cx3cl1 ENSMUST00000034230.7 C-X3-C motif chemokine ligand 1 (from RefSeq NM_009142.3) Cx3c Cx3cl1 ENSMUST00000034230.1 ENSMUST00000034230.2 ENSMUST00000034230.3 ENSMUST00000034230.4 ENSMUST00000034230.5 ENSMUST00000034230.6 Fkn NM_009142 O35188 O35933 Q91V44 Scyd1 X3CL1_MOUSE uc009mwx.1 uc009mwx.2 uc009mwx.3 uc009mwx.4 Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1 (PubMed:10187784, PubMed:18971423). The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:10382755, PubMed:9177350, PubMed:10187784, PubMed:18971423). Regulates leukocyte adhesion and migration processes at the endothelium (PubMed:10382755, PubMed:9177350). Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner (By similarity). In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins (By similarity). In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (By similarity). [Processed fractalkine]: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. [Fractalkine]: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. Monomer (By similarity). Forms a ternary complex with CX3CR1 and ITGAV:ITGB3 or ITGA4:ITGB1 (By similarity). Cell membrane ; Single-pass type I membrane protein [Processed fractalkine]: Secreted Highest levels in brain (PubMed:9177350, PubMed:9479488, PubMed:9845323, PubMed:10508268). Lower levels in kidney, heart and lung (PubMed:9177350, PubMed:9479488, PubMed:10508268). Also found in skeletal muscle and testis (PubMed:9177350, PubMed:9479488). Highly expressed in lesional smooth muscle cells, but not macrophages (PubMed:12569158). Low levels of ABCD-3 mRNA were also found in anti-CD40-stimulated splenic B-cells, but not in resting B-cells. Also expressed in dendritic cells (PubMed:10508268). By 12-O-tetradecanoylphorbol-13-acetate (TPA) and lipopolysaccharides (LPS) in bone marrow stroma cells. A soluble short 80 kDa form may be released by proteolytic cleavage from the long membrane-anchored form. No visible phenotype (PubMed:11287620). Mice develop normally and have normal migration of leukocytes to lymphoid tissue and peripheral sites in several models of inflammation (PubMed:11287620). Belongs to the intercrine delta family. microglial cell activation positive regulation of neuroblast proliferation leukocyte migration involved in inflammatory response monocyte chemotaxis response to ischemia cytokine activity integrin binding extracellular region extracellular space cytoplasm plasma membrane chemotaxis inflammatory response immune response cell adhesion G-protein coupled receptor signaling pathway chemokine activity positive regulation of cell proliferation cell surface positive regulation of macrophage chemotaxis positive regulation of neuron projection development membrane integral component of membrane cytokine-mediated signaling pathway platelet activation positive regulation of cell migration negative regulation of cell migration neutrophil chemotaxis regulation of lipopolysaccharide-mediated signaling pathway CX3C chemokine receptor binding positive regulation of actin filament bundle assembly negative regulation of interleukin-1 alpha production positive regulation of transforming growth factor beta1 production integrin activation autocrine signaling chemoattractant activity wound healing cell projection neuron projection neuronal cell body negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade positive regulation of GTPase activity cell body CXCR1 chemokine receptor binding positive regulation of angiogenesis positive regulation of cell adhesion negative regulation of vasoconstriction positive regulation of transcription from RNA polymerase II promoter CCR chemokine receptor binding eosinophil chemotaxis macrophage chemotaxis lymphocyte chemotaxis perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation negative regulation of cytokine secretion positive regulation of inflammatory response leukocyte adhesive activation positive chemotaxis positive regulation of calcium-independent cell-cell adhesion positive regulation of NF-kappaB transcription factor activity positive regulation of release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling angiogenesis involved in wound healing inhibitory postsynaptic potential cell chemotaxis microglial cell proliferation neuron cellular homeostasis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cell-cell adhesion postsynapse negative regulation of glutamate receptor signaling pathway positive regulation of I-kappaB phosphorylation negative regulation of microglial cell activation negative regulation of tumor necrosis factor secretion negative regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc009mwx.1 uc009mwx.2 uc009mwx.3 uc009mwx.4 
ENSMUST00000034231.4 Ccl22 ENSMUST00000034231.4 C-C motif chemokine ligand 22 (from RefSeq NM_009137.2) Ccl22 DCBCK ENSMUST00000034231.1 ENSMUST00000034231.2 ENSMUST00000034231.3 NM_009137 Q546S6 Q546S6_MOUSE uc009mww.1 uc009mww.2 uc009mww.3 Secreted Belongs to the intercrine beta (chemokine CC) family. cytokine activity extracellular region extracellular space chemotaxis inflammatory response immune response signal transduction chemokine activity cell chemotaxis uc009mww.1 uc009mww.2 uc009mww.3 
ENSMUST00000034232.3 Ccl17 ENSMUST00000034232.3 C-C motif chemokine ligand 17 (from RefSeq NM_011332.3) Ccl17 ENSMUST00000034232.1 ENSMUST00000034232.2 F6R5P4 F6R5P4_MOUSE NM_011332 uc009mwz.1 uc009mwz.2 uc009mwz.3 Secreted Belongs to the intercrine beta (chemokine CC) family. monocyte chemotaxis cytokine activity protein binding extracellular region extracellular space chemotaxis inflammatory response immune response cellular defense response signal transduction G-protein coupled receptor signaling pathway chemokine activity neutrophil chemotaxis killing of cells of other organism CCR4 chemokine receptor binding positive regulation of GTPase activity negative regulation of myoblast differentiation CCR chemokine receptor binding lymphocyte chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor uc009mwz.1 uc009mwz.2 uc009mwz.3 
ENSMUST00000034234.15 Coq9 ENSMUST00000034234.15 coenzyme Q9 (from RefSeq NM_026452.3) COQ9_MOUSE ENSMUST00000034234.1 ENSMUST00000034234.10 ENSMUST00000034234.11 ENSMUST00000034234.12 ENSMUST00000034234.13 ENSMUST00000034234.14 ENSMUST00000034234.2 ENSMUST00000034234.3 ENSMUST00000034234.4 ENSMUST00000034234.5 ENSMUST00000034234.6 ENSMUST00000034234.7 ENSMUST00000034234.8 ENSMUST00000034234.9 NM_026452 Q8K1Z0 Q9CT61 uc009mxd.1 uc009mxd.2 uc009mxd.3 Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25339443). Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7 (By similarity). Cofactor biosynthesis; ubiquinone biosynthesis. Homodimer. Interacts with COQ7. Mitochondrion Structurally similar to the bacterial FadR protein (fatty acid metabolism regulator protein). Encephalomyopathy due to a widespread coenzyme Q deficiency and accumulation of demethoxyubiquinone. Lethality between 3 and 6 months of age, due to neuronal death and demyelinization with severe vacuolization and astrogliosis in the brain. Belongs to the COQ9 family. mitochondrion mitochondrial inner membrane mitochondrial electron transport, NADH to ubiquinone ubiquinone biosynthetic process lipid binding protein homodimerization activity uc009mxd.1 uc009mxd.2 uc009mxd.3 
ENSMUST00000034239.9 Katnb1 ENSMUST00000034239.9 katanin p80 (WD40-containing) subunit B 1 (from RefSeq NM_028805.2) ENSMUST00000034239.1 ENSMUST00000034239.2 ENSMUST00000034239.3 ENSMUST00000034239.4 ENSMUST00000034239.5 ENSMUST00000034239.6 ENSMUST00000034239.7 ENSMUST00000034239.8 KTNB1_MOUSE NM_028805 Q8BG40 Q8CD18 Q8R1J0 Q9CWV2 uc009mxt.1 uc009mxt.2 uc009mxt.3 Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. The function in regulating microtubule dynamics at spindle poles seems to depend on the association of the katanin KATNA1:KATNB1 complex with ASPM which recruits it to microtubules. Reversely KATNA1:KATNB1 can enhance ASPM blocking activity on microtubule minus-end growth. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome (PubMed:16203747). This interaction is weakly competed by KATNBL1 which has a lower affinity for it (By similarity). Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM (PubMed:28436967). Interacts with dynein, microtubules, NDEL1 and PAFAH1B1 (PubMed:16203747). Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it (By similarity). Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches (By similarity). Q8BG40; Q9WV86: Katna1; NbExp=8; IntAct=EBI-7692933, EBI-7692898; Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, spindle Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (By similarity). Homozygous loss of the gene is embryonic lethal. Mutant animals have dramatically reduced body size, reduced limb bud outgrowth, microphthalmia to anophthalmia and forebrain abnormalities ranging from microcephaly to holoprosencephaly. Brains of mutant mice have reduced cycling and proliferating radial neuroepithelial progenitor cells compared to wild-type, with a more profound loss of cells that depend upon asymmetrical cell divisions. These cells also show evidence of increased apoptosis. Belongs to the WD repeat KATNB1 family. spindle pole protein binding cytoplasm centrosome microtubule organizing center spindle cytosol cytoskeleton microtubule plasma membrane negative regulation of microtubule depolymerization cell cycle mitotic chromosome movement towards spindle pole microtubule binding katanin complex microtubule-severing ATPase activity positive regulation of cell death positive regulation of neuron projection development microtubule cytoskeleton axon growth cone midbody positive regulation of microtubule depolymerization neuronal cell body protein heterodimerization activity microtubule severing cell division dynein complex binding uc009mxt.1 uc009mxt.2 uc009mxt.3 
ENSMUST00000034240.15 Kifc3 ENSMUST00000034240.15 kinesin family member C3, transcript variant 1 (from RefSeq NM_010631.3) ENSMUST00000034240.1 ENSMUST00000034240.10 ENSMUST00000034240.11 ENSMUST00000034240.12 ENSMUST00000034240.13 ENSMUST00000034240.14 ENSMUST00000034240.2 ENSMUST00000034240.3 ENSMUST00000034240.4 ENSMUST00000034240.5 ENSMUST00000034240.6 ENSMUST00000034240.7 ENSMUST00000034240.8 ENSMUST00000034240.9 KIFC3_MOUSE NM_010631 O35072 O35231 Q1WNZ8 Q3UX36 Q3V0U4 Q6NS71 Q8R3Y4 Q91YQ2 Q99KP7 uc009mxv.1 uc009mxv.2 uc009mxv.3 Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance. Interacts with annexin XIIIB. O35231; Q9WTX8: Mad1l1; NbExp=3; IntAct=EBI-11097964, EBI-4285225; Cytoplasm, cytoskeleton Cytoplasmic vesicle membrane ; Peripheral membrane protein Cell junction, adherens junction Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes along zonula adherens only at mature cell-cell contacts (By similarity). Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O35231-1; Sequence=Displayed; Name=2; IsoId=O35231-2; Sequence=VSP_022363, VSP_022364; Predominant expression in the kidney, testis and ovary. Also expressed in brain, heart, liver, lung and uterus. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Sequence=AAH70429.1; Type=Erroneous initiation; Evidence=; Sequence=BAE21409.1; Type=Erroneous initiation; Evidence=; nucleotide binding microtubule motor activity ATP binding cytoplasm Golgi apparatus centrosome microtubule organizing center cytoskeleton kinesin complex microtubule adherens junction zonula adherens microtubule-based process microtubule-based movement Golgi organization microtubule binding ATP-dependent microtubule motor activity, minus-end-directed membrane ATPase activity cell junction cytoplasmic vesicle membrane cytoplasmic vesicle zonula adherens maintenance epithelial cell-cell adhesion uc009mxv.1 uc009mxv.2 uc009mxv.3 
ENSMUST00000034243.7 Mmp15 ENSMUST00000034243.7 matrix metallopeptidase 15 (from RefSeq NM_008609.4) ENSMUST00000034243.1 ENSMUST00000034243.2 ENSMUST00000034243.3 ENSMUST00000034243.4 ENSMUST00000034243.5 ENSMUST00000034243.6 MMP15_MOUSE NM_008609 O54732 uc009myh.1 uc009myh.2 uc009myh.3 uc009myh.4 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. A deficiency of the encoded protein in mice is compatible with normal development and postnatal growth. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047278.1, D86332.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Membrane ; Single-pass type I membrane protein ; Extracellular side The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Belongs to the peptidase M10A family. metalloendopeptidase activity extracellular space integral component of plasma membrane proteolysis peptidase activity metallopeptidase activity zinc ion binding membrane integral component of membrane hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix response to estradiol endodermal cell differentiation metal ion binding uc009myh.1 uc009myh.2 uc009myh.3 uc009myh.4 
ENSMUST00000034244.9 Tmem38a ENSMUST00000034244.9 transmembrane protein 38A, transcript variant 1 (from RefSeq NM_144534.2) A5A6S4 A7LBB7 ENSMUST00000034244.1 ENSMUST00000034244.2 ENSMUST00000034244.3 ENSMUST00000034244.4 ENSMUST00000034244.5 ENSMUST00000034244.6 ENSMUST00000034244.7 ENSMUST00000034244.8 NM_144534 Q3TMP8 Q3TZB9 Q91WL2 TM38A_MOUSE uc009mgi.1 uc009mgi.2 uc009mgi.3 uc009mgi.4 Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2). Sarcoplasmic reticulum membrane ; Multi-pass membrane protein Nucleus membrane Expressed at high levels in heart and striated muscle. Also detected in brain, lung and kidney. Mice are viable. Mice lacking Tmem38a and Tmem38b show a weak heartbeat at E9.5 followed by loss of cardiomyocyte viability and embryonic lethality around 10.5 dpc. Belongs to the TMEM38 family. cation channel activity potassium channel activity nucleus ion transport potassium ion transport endoplasmic reticulum organization regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion release of sequestered calcium ion into cytosol by sarcoplasmic reticulum calcium-activated potassium channel activity monovalent inorganic cation transport membrane integral component of membrane sarcoplasmic reticulum nuclear membrane sarcoplasmic reticulum membrane identical protein binding cellular response to caffeine potassium ion transmembrane transport uc009mgi.1 uc009mgi.2 uc009mgi.3 uc009mgi.4 
ENSMUST00000034245.16 Usb1 ENSMUST00000034245.16 U6 snRNA biogenesis 1, transcript variant 1 (from RefSeq NM_133954.3) A0A0R4J0E0 A0A0R4J0E0_MOUSE ENSMUST00000034245.1 ENSMUST00000034245.10 ENSMUST00000034245.11 ENSMUST00000034245.12 ENSMUST00000034245.13 ENSMUST00000034245.14 ENSMUST00000034245.15 ENSMUST00000034245.2 ENSMUST00000034245.3 ENSMUST00000034245.4 ENSMUST00000034245.5 ENSMUST00000034245.6 ENSMUST00000034245.7 ENSMUST00000034245.8 ENSMUST00000034245.9 NM_133954 USB1 Usb1 uc009myg.1 uc009myg.2 uc009myg.3 uc009myg.4 Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Reaction=a 3'-end uridylyl-adenosine-RNA = a 3'-end 2',3'-cyclophospho- uridine-RNA + adenosine; Xref=Rhea:RHEA:67896, Rhea:RHEA-COMP:17385, Rhea:RHEA-COMP:17386, ChEBI:CHEBI:16335, ChEBI:CHEBI:85644, ChEBI:CHEBI:176518; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67897; Evidence=; Reaction=a 3'-end uridylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho- uridine-RNA + uridine; Xref=Rhea:RHEA:46052, Rhea:RHEA-COMP:17384, Rhea:RHEA-COMP:17385, ChEBI:CHEBI:16704, ChEBI:CHEBI:85643, ChEBI:CHEBI:85644; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46053; Evidence=; Nucleus Belongs to the 2H phosphoesterase superfamily. USB1 family. 3'-5'-exoribonuclease activity nuclease activity nucleus RNA splicing hydrolase activity U6 snRNA 3'-end processing intercellular bridge nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends uc009myg.1 uc009myg.2 uc009myg.3 uc009myg.4 
ENSMUST00000034249.8 Cfap20 ENSMUST00000034249.8 cilia and flagella associated protein 20 (from RefSeq NM_008187.2) CFA20_MOUSE ENSMUST00000034249.1 ENSMUST00000034249.2 ENSMUST00000034249.3 ENSMUST00000034249.4 ENSMUST00000034249.5 ENSMUST00000034249.6 ENSMUST00000034249.7 Gtl3 NM_008187 P70212 Q3T9D6 Q8BTU1 uc009myj.1 uc009myj.2 uc009myj.3 uc009myj.4 Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation. Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, cilium axoneme Note=Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BTU1-1; Sequence=Displayed; Name=2; IsoId=Q8BTU1-2; Sequence=VSP_027219; Widely expressed, with highest levels in testis and lowest in muscle. Expressed at high levels in germinal vesicle stage oocytes at the mRNA level. Expression progressively decreases until blastocyst stage (PubMed:15803458). Detected in later embryonic stages from 9.5 to 19.5 dpc. At 11.5 dpc, the expression is widespread, with no preference for any particular organ or structure (PubMed:8688464). Belongs to the CFAP20 family. nucleus cytoplasm centriole cytoskeleton microtubule cilium protein polyglutamylation motile cilium ciliary basal body cell projection cilium assembly regulation of cilium beat frequency involved in ciliary motility positive regulation of cell motility positive regulation of feeding behavior uc009myj.1 uc009myj.2 uc009myj.3 uc009myj.4 
ENSMUST00000034260.9 B3gnt3 ENSMUST00000034260.9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (from RefSeq NM_028189.3) B3GN3_MOUSE ENSMUST00000034260.1 ENSMUST00000034260.2 ENSMUST00000034260.3 ENSMUST00000034260.4 ENSMUST00000034260.5 ENSMUST00000034260.6 ENSMUST00000034260.7 ENSMUST00000034260.8 NM_028189 Q5JCS9 Q8R0U2 Q9D7Z2 uc009mer.1 uc009mer.2 uc009mer.3 uc009mer.4 uc009mer.5 uc009mer.6 Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides. Also acts as a core1-1,3-N- acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans. Reaction=3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl- (1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP- N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal- (1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:56224, Rhea:RHEA-COMP:14420, Rhea:RHEA- COMP:14422, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:139607, ChEBI:CHEBI:139612; EC=2.4.1.146; Evidence=; Reaction=3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl- (1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N- acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal- (1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:56220, Rhea:RHEA-COMP:14419, Rhea:RHEA- COMP:14421, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:139605, ChEBI:CHEBI:139611; EC=2.4.1.146; Evidence=; Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D- glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D- glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:14389, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:133507, ChEBI:CHEBI:134090; EC=2.4.1.149; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 31 family. Name=Functional Glycomics Gateway - GTase; Note=beta 3 GlcNAc-T III; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_572"; Golgi membrane endoplasmic reticulum Golgi apparatus protein glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups poly-N-acetyllactosamine biosynthetic process beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity uc009mer.1 uc009mer.2 uc009mer.3 uc009mer.4 uc009mer.5 uc009mer.6 
ENSMUST00000034261.8 Insl3 ENSMUST00000034261.8 insulin-like 3 (from RefSeq NM_013564.7) ENSMUST00000034261.1 ENSMUST00000034261.2 ENSMUST00000034261.3 ENSMUST00000034261.4 ENSMUST00000034261.5 ENSMUST00000034261.6 ENSMUST00000034261.7 Insl3 NM_013564 Q5RL10 Q5RL10_MOUSE uc009meq.1 uc009meq.2 uc009meq.3 uc009meq.4 Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. Heterodimer of a B chain and an A chain linked by two disulfide bonds. Secreted Belongs to the insulin family. oocyte maturation G-protein coupled receptor binding hormone activity extracellular region extracellular space adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation male gonad development negative regulation of apoptotic process positive regulation of cAMP-mediated signaling perinuclear region of cytoplasm uc009meq.1 uc009meq.2 uc009meq.3 uc009meq.4 
ENSMUST00000034264.11 Pgls ENSMUST00000034264.11 6-phosphogluconolactonase, transcript variant 1 (from RefSeq NM_025396.3) 6PGL_MOUSE ENSMUST00000034264.1 ENSMUST00000034264.10 ENSMUST00000034264.2 ENSMUST00000034264.3 ENSMUST00000034264.4 ENSMUST00000034264.5 ENSMUST00000034264.6 ENSMUST00000034264.7 ENSMUST00000034264.8 ENSMUST00000034264.9 NM_025396 Q3TA62 Q9CQ60 uc009meb.1 uc009meb.2 uc009meb.3 Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31; Carbohydrate degradation; pentose phosphate pathway; D- ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. Cytoplasm Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. cytoplasm carbohydrate metabolic process pentose-phosphate shunt pentose-phosphate shunt, oxidative branch hydrolase activity 6-phosphogluconolactonase activity monosaccharide binding uc009meb.1 uc009meb.2 uc009meb.3 
ENSMUST00000034265.11 1700018B08Rik ENSMUST00000034265.11 RIKEN cDNA 1700018B08 gene, transcript variant 1 (from RefSeq NM_029597.2) 1700018B08Rik ENSMUST00000034265.1 ENSMUST00000034265.10 ENSMUST00000034265.2 ENSMUST00000034265.3 ENSMUST00000034265.4 ENSMUST00000034265.5 ENSMUST00000034265.6 ENSMUST00000034265.7 ENSMUST00000034265.8 ENSMUST00000034265.9 NM_029597 Q9DA83 Q9DA83_MOUSE uc009nrt.1 uc009nrt.2 uc009nrt.3 molecular_function cellular_component biological_process uc009nrt.1 uc009nrt.2 uc009nrt.3 
ENSMUST00000034270.17 Map1lc3b ENSMUST00000034270.17 microtubule-associated protein 1 light chain 3 beta, transcript variant 1 (from RefSeq NM_026160.5) ENSMUST00000034270.1 ENSMUST00000034270.10 ENSMUST00000034270.11 ENSMUST00000034270.12 ENSMUST00000034270.13 ENSMUST00000034270.14 ENSMUST00000034270.15 ENSMUST00000034270.16 ENSMUST00000034270.2 ENSMUST00000034270.3 ENSMUST00000034270.4 ENSMUST00000034270.5 ENSMUST00000034270.6 ENSMUST00000034270.7 ENSMUST00000034270.8 ENSMUST00000034270.9 MLP3B_MOUSE Map1alc3 Map1lc3 Map1lc3b NM_026160 Q3U9W5 Q9CQV6 Q9D1R0 uc009nrw.1 uc009nrw.2 uc009nrw.3 Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Upon nutrient stress, directly recruits cofactor JMY to the phagophore membrane surfaces and promotes JMY's actin nucleation activity and autophagosome biogenesis during autophagy. 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin. Interacts with FYCO1 (via C-terminus). Interacts with TP53INP1 and TP53INP2 (By similarity). Interacts with TBC1D25 (PubMed:21383079). Directly interacts with SQSTM1; this interaction leads to MAP1LC3B recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy. Interacts with ATG4B, MAPK15 and BNIP3. Interacts with MAPB1, KEAP1, PCM1, OFD1, CEP131, and TECPR2. Interacts with TBC1D5. Found in a complex with UBQLN1 and UBQLN2. Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4. Interacts with ATG13. Interacts with reticulophagy regulators RETREG1, RETREG2 and RETREG3 (PubMed:34338405). Interacts with PLCL1; the interaction inhibits autophagosome formation (PubMed:23399561). Interacts with TRIM16. Interacts with CRY1 and PER2 (PubMed:29937374). Interacts with the reticulophagy receptor TEX264 (By similarity). Membrane-bound form LC3- II interacts with PHB1 and PHB2; the interaction takes place upon Parkin-mediated mitochondrial damage (By similarity). Interacts with PJVK; the interaction is direct (PubMed:30936319). Interacts with KBTBD6 and KBTBD7; the interaction is direct (By similarity). Interacts with AMBRA1 (via LIR motif) (By similarity). Interacts with JMY; the interaction results in the activation of JYM's nucleation activity in the cytoplasm (By similarity). Interacts with MOAP1 (via LIR motif) (By similarity). Interacts with TAX1BP1 (By similarity). Interacts with Irgm1 (By similarity). Interacts with STX17 (By similarity). Interacts (the lipidate and non-lipidated LC3 form) with DNM2; this interaction mediates recycling endosome scission leading to autophagosome release (By similarity). Cytoplasmic vesicle, autophagosome membrane ; Lipid- anchor Endomembrane system ; Lipid-anchor Mitochondrion membrane ; Lipid-anchor Cytoplasm, cytoskeleton Cytoplasmic vesicle Note=LC3-II binds to the autophagic membranes. LC3-II localizes with the mitochondrial inner membrane during Parkin-mediated mitophagy (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). The precursor molecule is cleaved by ATG4 (ATG4A, ATG4B, ATG4C or ATG4D) to expose the glycine at the C-terminus and form the cytosolic form, LC3-I (PubMed:12207896, PubMed:14530254). The processed form is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, LC3-II (By similarity). During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid (By similarity). ATG4 proteins also mediate the delipidation of PE- conjugated forms (PubMed:33795848). In addition, ATG4B and ATG4D mediate delipidation of ATG8 proteins conjugated to PS during non- canonical autophagy (By similarity). ATG4B constitutes the major protein for proteolytic activation (By similarity). ATG4D is the main enzyme for delipidation activity (PubMed:33795848). Phosphorylation by PKA inhibits conjugation of phosphatidylethanolamine (PE). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity. Belongs to the ATG8 family. autophagosome assembly autophagosome membrane mitophagy protein binding cytoplasm mitochondrion autophagosome cytosol cytoskeleton microtubule microtubule associated complex axoneme autophagy cellular response to nitrogen starvation microtubule binding cellular response to starvation endomembrane system tubulin binding membrane macroautophagy protein domain specific binding axon dendrite cytoplasmic vesicle ubiquitin protein ligase binding positive regulation of protein binding neuronal cell body autolysosome positive regulation of mucus secretion autophagosome maturation uc009nrw.1 uc009nrw.2 uc009nrw.3 
ENSMUST00000034272.9 Mvb12a ENSMUST00000034272.9 multivesicular body subunit 12A (from RefSeq NM_028617.2) ENSMUST00000034272.1 ENSMUST00000034272.2 ENSMUST00000034272.3 ENSMUST00000034272.4 ENSMUST00000034272.5 ENSMUST00000034272.6 ENSMUST00000034272.7 ENSMUST00000034272.8 Fam125a MB12A_MOUSE NM_028617 Q78HU3 uc009mdt.1 uc009mdt.2 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity). Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with CD2AP and CIN85/SH3KBP1. Interacts with CD2AP (via one of the SH3 domains). Interacts with TSG101; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS28. Interacts with VPS37B; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37C; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37D; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with CEP55 (By similarity). Cytoplasm, cytoskeleton Nucleus Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Late endosome membrane ; Peripheral membrane protein Note=Colocalizes with F- actin. Some fraction may be nuclear (By similarity). Phosphorylated on Tyr-202 upon EGF stimulation. Phosphorylation is required for interaction with CD2AP and CIN85/SH3KBP1 (By similarity). Belongs to the MVB12 family. ESCRT I complex nucleus nucleoplasm cytoplasm endosome Golgi apparatus centrosome microtubule organizing center cytosol cytoskeleton lipid binding protein transport membrane SH3 domain binding virus maturation late endosome membrane vesicle endosome to lysosome transport via multivesicular body sorting pathway receptor catabolic process regulation of epidermal growth factor receptor signaling pathway ubiquitin binding viral budding uc009mdt.1 uc009mdt.2 
ENSMUST00000034277.14 Emc8 ENSMUST00000034277.14 ER membrane protein complex subunit 8 (from RefSeq NM_010926.6) Cox4nb ENSMUST00000034277.1 ENSMUST00000034277.10 ENSMUST00000034277.11 ENSMUST00000034277.12 ENSMUST00000034277.13 ENSMUST00000034277.2 ENSMUST00000034277.3 ENSMUST00000034277.4 ENSMUST00000034277.5 ENSMUST00000034277.6 ENSMUST00000034277.7 ENSMUST00000034277.8 ENSMUST00000034277.9 Emc8 NM_010926 Q3TPU5 Q3TPU5_MOUSE uc009nrf.1 uc009nrf.2 uc009nrf.3 uc009nrf.4 Belongs to the EMC8/EMC9 family. cytoplasm cytosol ER membrane protein complex uc009nrf.1 uc009nrf.2 uc009nrf.3 uc009nrf.4 
ENSMUST00000034278.6 Gins2 ENSMUST00000034278.6 GINS complex subunit 2 (from RefSeq NM_178856.1) ENSMUST00000034278.1 ENSMUST00000034278.2 ENSMUST00000034278.3 ENSMUST00000034278.4 ENSMUST00000034278.5 NM_178856 PSF2_MOUSE Psf2 Q8BMT2 Q9D600 uc009nrd.1 uc009nrd.2 uc009nrd.3 Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS3. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex. Nucleus Chromosome Note=Associates with chromatin. Belongs to the GINS2/PSF2 family. double-strand break repair via break-induced replication GINS complex nucleus DNA replication replication fork protection complex DNA duplex unwinding 3'-5' DNA helicase activity uc009nrd.1 uc009nrd.2 uc009nrd.3 
ENSMUST00000034279.16 Gse1 ENSMUST00000034279.16 genetic suppressor element 1, coiled-coil protein, transcript variant 1 (from RefSeq NM_198671.2) ENSMUST00000034279.1 ENSMUST00000034279.10 ENSMUST00000034279.11 ENSMUST00000034279.12 ENSMUST00000034279.13 ENSMUST00000034279.14 ENSMUST00000034279.15 ENSMUST00000034279.2 ENSMUST00000034279.3 ENSMUST00000034279.4 ENSMUST00000034279.5 ENSMUST00000034279.6 ENSMUST00000034279.7 ENSMUST00000034279.8 ENSMUST00000034279.9 GSE1_MOUSE Kiaa0182 NM_198671 Q3U3C9 Q3UWZ5 Q80U67 Q80XR0 Q8CCF2 uc009nqz.1 uc009nqz.2 uc009nqz.3 uc009nqz.4 May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3U3C9-1; Sequence=Displayed; Name=2; IsoId=Q3U3C9-2; Sequence=VSP_021823; Name=3; IsoId=Q3U3C9-3; Sequence=VSP_021822; Name=4; IsoId=Q3U3C9-4; Sequence=VSP_021824; Sequence=AAH43094.1; Type=Erroneous initiation; Evidence=; Sequence=BAC28215.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc009nqz.1 uc009nqz.2 uc009nqz.3 uc009nqz.4 
ENSMUST00000034280.9 Zdhhc7 ENSMUST00000034280.9 zinc finger, DHHC domain containing 7 (from RefSeq NM_133967.3) ENSMUST00000034280.1 ENSMUST00000034280.2 ENSMUST00000034280.3 ENSMUST00000034280.4 ENSMUST00000034280.5 ENSMUST00000034280.6 ENSMUST00000034280.7 ENSMUST00000034280.8 Gramp2 NM_133967 Q3TC41 Q6EMK2 Q8K1H6 Q91WU6 ZDHC7_MOUSE Zdhhc7 uc009nqr.1 uc009nqr.2 uc009nqr.3 Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (PubMed:15603741, PubMed:19001095, PubMed:23687301, PubMed:25253725). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones. Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways (PubMed:19001095). Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane. In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation. Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (By similarity). Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (PubMed:28057756). In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (PubMed:15603741, PubMed:25253725). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (PubMed:18596047). Could also palmitoylate NCDN (PubMed:23687301). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Reaction=L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S- tetradecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59736, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:15433, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:143199; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59737; Evidence=; Reaction=L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S- octadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59740, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:15434, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:143200; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59741; Evidence=; Homooligomers (PubMed:17151279). Heterooligomers with ZDHHC3 (PubMed:17151279). Golgi apparatus membrane ; Multi-pass membrane protein Ubiquitously expressed, with highest levels in liver, kidney and brain. Expressed in all brain regions. The DHHC domain is required for palmitoyltransferase activity. Autopalmitoylated. Homozygous knockout mice are viable, fertile and do not display overt phenotype (PubMed:27875292). Knockout mice are hyperglycemic, glucose intolerant and develop a type II diabetic syndrome (PubMed:28057756). Zdhhc3 and Zdhhc7 double knockout mice show a perinatally lethal phenotype (PubMed:27875292). Belongs to the DHHC palmitoyltransferase family. Golgi membrane endoplasmic reticulum Golgi apparatus protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity uc009nqr.1 uc009nqr.2 uc009nqr.3 
ENSMUST00000034282.16 Crispld2 ENSMUST00000034282.16 cysteine-rich secretory protein LCCL domain containing 2, transcript variant 1 (from RefSeq NM_001310635.1) CRLD2_MOUSE ENSMUST00000034282.1 ENSMUST00000034282.10 ENSMUST00000034282.11 ENSMUST00000034282.12 ENSMUST00000034282.13 ENSMUST00000034282.14 ENSMUST00000034282.15 ENSMUST00000034282.2 ENSMUST00000034282.3 ENSMUST00000034282.4 ENSMUST00000034282.5 ENSMUST00000034282.6 ENSMUST00000034282.7 ENSMUST00000034282.8 ENSMUST00000034282.9 NM_001310635 Q3U4C7 Q8BZQ2 Q9D2R3 uc012glv.1 uc012glv.2 uc012glv.3 uc012glv.4 Promotes matrix assembly. Binds to heparin, dermatan sulfate and chondroitin sulfate. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZQ2-1; Sequence=Displayed; Name=2; IsoId=Q8BZQ2-2; Sequence=VSP_036331; Present in kidney renal tubules (at protein level). Expressed in the developing oropharynx and nasopharynx at 13.5 dpc, in the mandible at 14.5 dpc and in the cartilage primordia of the nasal bones, palate and tooth germs at 17.5 dpc. Detected in the embryonic liver at 13.5, 14.5 and 17.5 dpc. glycosaminoglycan binding extracellular region extracellular space heparin binding transport vesicle extracellular matrix organization lung development extracellular matrix face morphogenesis uc012glv.1 uc012glv.2 uc012glv.3 uc012glv.4 
ENSMUST00000034285.14 Cotl1 ENSMUST00000034285.14 coactosin like F-actin binding protein 1 (from RefSeq NM_028071.3) COTL1_MOUSE Clp ENSMUST00000034285.1 ENSMUST00000034285.10 ENSMUST00000034285.11 ENSMUST00000034285.12 ENSMUST00000034285.13 ENSMUST00000034285.2 ENSMUST00000034285.3 ENSMUST00000034285.4 ENSMUST00000034285.5 ENSMUST00000034285.6 ENSMUST00000034285.7 ENSMUST00000034285.8 ENSMUST00000034285.9 NM_028071 Q9CQI6 uc012glt.1 uc012glt.2 uc012glt.3 Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (By similarity). Interacts with 5-lipoxygenase (ALOX5/5LO) in a calcium- independent manner. Binds to F-actin with a stoichiometry of 1:2 (By similarity). Cytoplasm Cytoplasm, cytoskeleton Nucleus Belongs to the actin-binding proteins ADF family. Coactosin subfamily. actin binding protein binding cellular_component nucleus cytoplasm cytoskeleton plasma membrane enzyme binding site of polarized growth regulation of actin filament polymerization cortical actin cytoskeleton defense response to fungus actin filament binding actin filament uc012glt.1 uc012glt.2 uc012glt.3 
ENSMUST00000034287.10 Klhl36 ENSMUST00000034287.10 kelch-like 36 (from RefSeq NM_146219.1) ENSMUST00000034287.1 ENSMUST00000034287.2 ENSMUST00000034287.3 ENSMUST00000034287.4 ENSMUST00000034287.5 ENSMUST00000034287.6 ENSMUST00000034287.7 ENSMUST00000034287.8 ENSMUST00000034287.9 KLH36_MOUSE NM_146219 Q3U0B9 Q6KAS2 Q8R124 uc009nqm.1 uc009nqm.2 uc009nqm.3 Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Interacts with CUL3. Sequence=BAD21385.1; Type=Erroneous initiation; Evidence=; protein ubiquitination uc009nqm.1 uc009nqm.2 uc009nqm.3 
ENSMUST00000034296.15 Pik3r2 ENSMUST00000034296.15 phosphoinositide-3-kinase regulatory subunit 2, transcript variant 1 (from RefSeq NM_008841.3) ENSMUST00000034296.1 ENSMUST00000034296.10 ENSMUST00000034296.11 ENSMUST00000034296.12 ENSMUST00000034296.13 ENSMUST00000034296.14 ENSMUST00000034296.2 ENSMUST00000034296.3 ENSMUST00000034296.4 ENSMUST00000034296.5 ENSMUST00000034296.6 ENSMUST00000034296.7 ENSMUST00000034296.8 ENSMUST00000034296.9 NM_008841 O08908 P85B_MOUSE Q5U3K7 uc009mbn.1 uc009mbn.2 uc009mbn.3 uc009mbn.4 Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (By similarity). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin- dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926). Heterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine- phosphorylated) (By similarity). Interacts with FBXL2; PIK3R2 is a substrate of the SCF(FBXL2) complex. Interacts with PTPN13; dephosphorylates PIK3R2 (By similarity). Interacts with NYAP1, NYAP2 and MYO16 (PubMed:21946561). Interacts with XBP1 isoform 2; the interaction is direct and induces translocation of XBP1 isoform 2 into the nucleus in a ER stress- and/or insulin-dependent but PI3K- independent manner (PubMed:20348926). Interacts with PIK3R1; the interaction is dissociated in an insulin-dependent manner (PubMed:20348926). Interacts with SRC (By similarity). O08908; O88665: Brd7; NbExp=4; IntAct=EBI-643570, EBI-643930; O08908; Q9JK42: Pdk2; NbExp=3; IntAct=EBI-643570, EBI-643530; The SH2 2 domain is required for interaction with FBXL2 and PTPN13. Phosphorylated in response to signaling from activated receptor- type protein kinases. Dephosphorylated by PTPRJ. Dephosphorylated at Tyr-649 by PTPN13. Phosphorylation of Tyr-649 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)- mediated polyubiquitination. Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2. Belongs to the PI3K p85 subunit family. cellular glucose homeostasis phosphotyrosine binding protein binding nucleus focal adhesion phosphatidylinositol 3-kinase complex signal transduction transcription factor binding insulin receptor signaling pathway regulation of autophagy phosphatidylinositol 3-kinase signaling protein transport protein phosphatase binding regulation of actin filament polymerization receptor tyrosine kinase binding cellular response to insulin stimulus response to endoplasmic reticulum stress phosphatidylinositol 3-kinase regulatory subunit binding positive regulation of protein import into nucleus negative regulation of MAPK cascade regulation of phosphatidylinositol 3-kinase activity positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity protein heterodimerization activity regulation of stress fiber assembly negative regulation of cell migration involved in sprouting angiogenesis regulation of protein localization to plasma membrane uc009mbn.1 uc009mbn.2 uc009mbn.3 uc009mbn.4 
ENSMUST00000034300.8 Hsbp1 ENSMUST00000034300.8 heat shock factor binding protein 1 (from RefSeq NM_024219.1) ENSMUST00000034300.1 ENSMUST00000034300.2 ENSMUST00000034300.3 ENSMUST00000034300.4 ENSMUST00000034300.5 ENSMUST00000034300.6 ENSMUST00000034300.7 HSBP1_MOUSE NM_024219 Q3UKN1 Q9CQZ1 uc009npm.1 uc009npm.2 uc009npm.3 Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer (By similarity). Nucleus Belongs to the HSBP1 family. transcription corepressor activity nucleus cytoplasm cytosol cytoskeleton muscle contraction endodermal cell differentiation identical protein binding cellular heat acclimation negative regulation of nucleic acid-templated transcription uc009npm.1 uc009npm.2 uc009npm.3 
ENSMUST00000034303.3 Mphosph6 ENSMUST00000034303.3 M phase phosphoprotein 6, transcript variant 1 (from RefSeq NM_026758.4) ENSMUST00000034303.1 ENSMUST00000034303.2 MPH6_MOUSE Mphosph6 NM_026758 Q9D1Q1 uc009npg.1 uc009npg.2 uc009npg.3 RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and plays a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. Associates with the RNA exosome complex, probably mediated by EXOSC10. Interacts with ARHGAP18, EXOSC10 and MTREX. Nucleus, nucleolus Cytoplasm Note=Cytoplasmic in M phase. Phosphorylated in M (mitotic) phase. Belongs to the MPP6 family. nuclear exosome (RNase complex) exosome (RNase complex) maturation of 5.8S rRNA molecular_function RNA binding nucleus nucleolus cytoplasm rRNA processing uc009npg.1 uc009npg.2 uc009npg.3 
ENSMUST00000034304.9 Hsd17b2 ENSMUST00000034304.9 hydroxysteroid (17-beta) dehydrogenase 2, transcript variant 1 (from RefSeq NM_008290.3) DHB2_MOUSE ENSMUST00000034304.1 ENSMUST00000034304.2 ENSMUST00000034304.3 ENSMUST00000034304.4 ENSMUST00000034304.5 ENSMUST00000034304.6 ENSMUST00000034304.7 ENSMUST00000034304.8 Edh17b2 NM_008290 O08898 P51658 uc009npf.1 uc009npf.2 uc009npf.3 Catalyzes the NAD-dependent oxidation of highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24613; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:24614; Evidence=; Reaction=NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:14929, ChEBI:CHEBI:15378, ChEBI:CHEBI:16422, ChEBI:CHEBI:17347, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.239; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14930; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:14931; Evidence=; Reaction=17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha- androstan-3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:41992, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:16330, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=(20S)-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone; Xref=Rhea:RHEA:42108, ChEBI:CHEBI:15378, ChEBI:CHEBI:17026, ChEBI:CHEBI:28453, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Homodimer. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Belongs to the short-chain dehydrogenases/reductases (SDR) family. in utero embryonic development placenta development estradiol 17-beta-dehydrogenase activity lipid metabolic process steroid biosynthetic process androgen biosynthetic process estrogen biosynthetic process membrane integral component of membrane oxidoreductase activity response to retinoic acid intracellular membrane-bounded organelle testosterone dehydrogenase (NAD+) activity oxidation-reduction process uc009npf.1 uc009npf.2 uc009npf.3 
ENSMUST00000034308.16 Bco1 ENSMUST00000034308.16 beta-carotene oxygenase 1, transcript variant 1 (from RefSeq NM_021486.4) BCDO1_MOUSE Bcdo Bcdo1 Bcmo1 Bco1 ENSMUST00000034308.1 ENSMUST00000034308.10 ENSMUST00000034308.11 ENSMUST00000034308.12 ENSMUST00000034308.13 ENSMUST00000034308.14 ENSMUST00000034308.15 ENSMUST00000034308.2 ENSMUST00000034308.3 ENSMUST00000034308.4 ENSMUST00000034308.5 ENSMUST00000034308.6 ENSMUST00000034308.7 ENSMUST00000034308.8 ENSMUST00000034308.9 NM_021486 Q6K1L5 Q8C6N5 Q9ERN9 Q9JJS6 uc009now.1 uc009now.2 uc009now.3 uc009now.4 Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. Two alternatively spliced variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]. Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism. Reaction=all-trans-beta-carotene + O2 = 2 all-trans-retinal; Xref=Rhea:RHEA:32887, ChEBI:CHEBI:15379, ChEBI:CHEBI:17579, ChEBI:CHEBI:17898; EC=1.13.11.63; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32888; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Kinetic parameters: KM=1.2 uM for all-trans-beta-carotene (at pH 8.0 and 37 degrees Celsius) ; Vmax=104.8 pmol/h/ug enzyme for the formation of all-trans-retinal (at pH 8.0 and 37 degrees Celsius) ; Cofactor metabolism; retinol metabolism. Cytoplasm, cytosol Expressed in liver, kidney, small intestine and testis. Abundantly expressed at embryonic day 7 with lower levels at embryonic days 11, 13 and 15. Belongs to the carotenoid oxygenase family. retinoid metabolic process beta-carotene 15,15'-monooxygenase activity retinal isomerase activity carotenoid dioxygenase activity carotene catabolic process oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen retinol metabolic process retinal metabolic process metal ion binding dioxygenase activity oxidation-reduction process beta-carotene metabolic process uc009now.1 uc009now.2 uc009now.3 uc009now.4 
ENSMUST00000034311.15 Lsm4 ENSMUST00000034311.15 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated, transcript variant 1 (from RefSeq NM_015816.4) ENSMUST00000034311.1 ENSMUST00000034311.10 ENSMUST00000034311.11 ENSMUST00000034311.12 ENSMUST00000034311.13 ENSMUST00000034311.14 ENSMUST00000034311.2 ENSMUST00000034311.3 ENSMUST00000034311.4 ENSMUST00000034311.5 ENSMUST00000034311.6 ENSMUST00000034311.7 ENSMUST00000034311.8 ENSMUST00000034311.9 LSM4 Lsm4 NM_015816 Q9CY46 Q9CY46_MOUSE uc012gfd.1 uc012gfd.2 uc012gfd.3 Binds specifically to the 3'-terminal U-tract of U6 snRNA. LSm subunits form a heteromer with a doughnut shape. Nucleus Belongs to the snRNP Sm proteins family. mRNA splicing, via spliceosome nuclear-transcribed mRNA catabolic process RNA binding nucleus spliceosomal complex cytosol RNA processing mRNA processing RNA splicing membrane macromolecular complex PH domain binding neuron projection U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome uc012gfd.1 uc012gfd.2 uc012gfd.3 
ENSMUST00000034313.13 Ntpcr ENSMUST00000034313.13 nucleoside-triphosphatase, cancer-related, transcript variant 1 (from RefSeq NM_025636.5) ENSMUST00000034313.1 ENSMUST00000034313.10 ENSMUST00000034313.11 ENSMUST00000034313.12 ENSMUST00000034313.2 ENSMUST00000034313.3 ENSMUST00000034313.4 ENSMUST00000034313.5 ENSMUST00000034313.6 ENSMUST00000034313.7 ENSMUST00000034313.8 ENSMUST00000034313.9 NM_025636 NTPCR_MOUSE Ntpcr Q9CQA9 uc009nyk.1 uc009nyk.2 uc009nyk.3 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency. Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23681; Evidence=; Reaction=H2O + TTP = H(+) + phosphate + TDP; Xref=Rhea:RHEA:65580, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:61417, ChEBI:CHEBI:63527; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65581; Evidence=; Reaction=CTP + H2O = CDP + H(+) + phosphate; Xref=Rhea:RHEA:29387, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:58069; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29388; Evidence=; Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Monomer. Belongs to the THEP1 NTPase family. nucleotide binding ATP binding biological_process dephosphorylation hydrolase activity nucleoside-triphosphatase activity nucleotide phosphatase activity, acting on free nucleotides uc009nyk.1 uc009nyk.2 uc009nyk.3 
ENSMUST00000034316.6 Map3k21 ENSMUST00000034316.6 mitogen-activated protein kinase kinase kinase 21 (from RefSeq NM_145608.2) ENSMUST00000034316.1 ENSMUST00000034316.2 ENSMUST00000034316.3 ENSMUST00000034316.4 ENSMUST00000034316.5 Kiaa1804 M3K21_MOUSE Mlk4 NM_145608 Q5DTU6 Q811F5 Q8VDG6 uc009nyq.1 uc009nyq.2 uc009nyq.3 Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation. Homodimer. Interacts with TLR4. Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Sequence=BAD90469.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAD90469.1; Type=Frameshift; Evidence=; nucleotide binding activation of MAPKK activity protein kinase activity protein serine/threonine kinase activity JUN kinase kinase kinase activity MAP kinase kinase kinase activity ATP binding protein phosphorylation activation of JNKK activity activation of JUN kinase activity kinase activity phosphorylation transferase activity uc009nyq.1 uc009nyq.2 uc009nyq.3 
ENSMUST00000034325.6 Lpar2 ENSMUST00000034325.6 Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (By similarity). (from UniProt Q9JL06) BC064676 ENSMUST00000034325.1 ENSMUST00000034325.2 ENSMUST00000034325.3 ENSMUST00000034325.4 ENSMUST00000034325.5 Edg4 LPAR2_MOUSE Lpa2 Lpar2 Q6P290 Q9JL06 uc009lxw.1 uc009lxw.2 uc009lxw.3 Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (By similarity). Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3. Interacts with RALA and GRK2 (By similarity). Cell surface Cell membrane ; Multi-pass membrane protein Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles. Most abundantly expressed in testes, kidney, and embryonic brain. Other organs also express the transcript, including heart, lung, spleen, thymus, stomach, and adult brain. Several have little or no expression, including liver, small intestine, and skeletal muscle. Belongs to the G-protein coupled receptor 1 family. Sequence=AAF65684.1; Type=Frameshift; Note=Several.; Evidence=; activation of MAPK activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway cell surface membrane integral component of membrane PDZ domain binding positive regulation of Rho protein signal transduction positive regulation of MAPK cascade lysophosphatidic acid receptor activity glutamatergic synapse integral component of presynaptic active zone membrane endocytic vesicle uc009lxw.1 uc009lxw.2 uc009lxw.3 
ENSMUST00000034326.7 Atp13a1 ENSMUST00000034326.7 ATPase type 13A1 (from RefSeq NM_133224.2) AT131_MOUSE Atp13a Atp13a1 B2RS54 ENSMUST00000034326.1 ENSMUST00000034326.2 ENSMUST00000034326.3 ENSMUST00000034326.4 ENSMUST00000034326.5 ENSMUST00000034326.6 NM_133224 Q9EPE9 uc009lxr.1 uc009lxr.2 uc009lxr.3 uc009lxr.4 Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains. Reaction=[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:66168, Rhea:RHEA-COMP:16963, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:90782, ChEBI:CHEBI:456216; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Contains a large substrate-binding pocket that recognizes alpha-helical transmembranes, which alternately faces the endoplasmic reticulum lumen and cytosol, while remaining accessible to the lipid bilayer through a lateral opening. The translocase alternates between two conformations: inward-open (E1) and outward-open (E2) states. Undergoes a series of conformational changes with ATP-binding, phosphorylation of the Asp active site and subsequent dephosphorylation in a Post-Albers cycle (i.e., E1 -> E1-ATP -> E1P-ADP -> E1P -> E2P -> E2-Pi -> E1). A substrate transmembrane helix with a short, preferentially positively charged lumenal segment binds to the outward- open pocket and the E2P-to-E1 transition flips the transmembrane by a switch from the outward-open to inward-open conformation. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. nucleotide binding ATP binding endoplasmic reticulum endoplasmic reticulum membrane cation transport cellular calcium ion homeostasis membrane integral component of membrane hydrolase activity ATPase activity metal ion binding uc009lxr.1 uc009lxr.2 uc009lxr.3 uc009lxr.4 
ENSMUST00000034328.13 Ints10 ENSMUST00000034328.13 integrator complex subunit 10, transcript variant 3 (from RefSeq NM_027590.4) ENSMUST00000034328.1 ENSMUST00000034328.10 ENSMUST00000034328.11 ENSMUST00000034328.12 ENSMUST00000034328.2 ENSMUST00000034328.3 ENSMUST00000034328.4 ENSMUST00000034328.5 ENSMUST00000034328.6 ENSMUST00000034328.7 ENSMUST00000034328.8 ENSMUST00000034328.9 INT10_MOUSE NM_027590 Q8BYC2 Q8BZI9 Q8K2A7 Q9D5U1 uc009lwm.1 uc009lwm.2 uc009lwm.3 Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex. Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Interacts with POLR2A. Nucleus Belongs to the Integrator subunit 10 family. Sequence=BAC30632.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleus snRNA processing integrator complex uc009lwm.1 uc009lwm.2 uc009lwm.3 
ENSMUST00000034339.10 Cdh5 ENSMUST00000034339.10 cadherin 5 (from RefSeq NM_009868.4) CADH5_MOUSE ENSMUST00000034339.1 ENSMUST00000034339.2 ENSMUST00000034339.3 ENSMUST00000034339.4 ENSMUST00000034339.5 ENSMUST00000034339.6 ENSMUST00000034339.7 ENSMUST00000034339.8 ENSMUST00000034339.9 NM_009868 O35542 P55284 uc009mzx.1 uc009mzx.2 uc009mzx.3 uc009mzx.4 This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein die in utero due to vascular insufficiency, caused by increased endothelial apoptosis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK164474.1, BC054790.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (PubMed:9220534, PubMed:20332120). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (PubMed:27466317). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (By similarity). Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity). Interacts (via cadherin 5 domain) with PTPRB (PubMed:12234928). Interacts with TRPC4 (By similarity). Interacts with KRIT1 (By similarity). Interacts with PARD3 (PubMed:20047332). Interacts with RTN4 (isoform B) (By similarity). Interacts with PALS1; the interaction promotes PALS1 localization to cell junctions and is required for CDH5-mediated vascular lumen formation and endothelial cell polarity (PubMed:27466317). P55284; Q64729: Tgfbr1; NbExp=2; IntAct=EBI-7087433, EBI-2899393; P55284; Q62312: Tgfbr2; NbExp=4; IntAct=EBI-7087433, EBI-2899332; Cell junction Cell membrane ; Single-pass type I membrane protein Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions (By similarity). Expressed in postnatal endothelial cells of the retinal vascular plexus (at protein level). Expressed in endothelial cells of allantois/umbilical vessels at 8.5 dpc (at protein level) (PubMed:19635461). During hemangioblast differentiation, expressed in hemogenic endothelium cells and down-regulated in nascent blood precursors (PubMed:22492353). Expressed in the mesentery lymphatic vessels at 18.5 dpc (PubMed:28179430). Up-regulated by SOX7. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. O-glycosylated. cell morphogenesis regulation of protein phosphorylation blood vessel maturation receptor binding calcium ion binding protein binding plasma membrane cell-cell junction adherens junction cell-cell adherens junction bicellular tight junction cellular calcium ion homeostasis cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules transforming growth factor beta receptor signaling pathway beta-catenin binding cytoskeletal protein binding negative regulation of cell proliferation external side of plasma membrane cell surface positive regulation of gene expression membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex protein phosphatase binding cell junction positive regulation of cell migration positive regulation of BMP signaling pathway negative regulation of microtubule polymerization positive regulation of protein complex assembly adherens junction organization positive regulation of protein dephosphorylation protein homodimerization activity regulation of vascular permeability vascular endothelial growth factor receptor 2 binding ion channel binding cell-cell adhesion mediated by cadherin cadherin binding positive regulation of angiogenesis metal ion binding negative regulation of inflammatory response fibrinogen binding BMP receptor binding cell periphery cell-cell adhesion positive regulation of establishment of endothelial barrier protein tyrosine kinase binding regulation of establishment of cell polarity uc009mzx.1 uc009mzx.2 uc009mzx.3 uc009mzx.4 
ENSMUST00000034342.13 Cklf ENSMUST00000034342.13 chemokine-like factor, transcript variant 1 (from RefSeq NM_029295.3) CKLF_MOUSE ENSMUST00000034342.1 ENSMUST00000034342.10 ENSMUST00000034342.11 ENSMUST00000034342.12 ENSMUST00000034342.2 ENSMUST00000034342.3 ENSMUST00000034342.4 ENSMUST00000034342.5 ENSMUST00000034342.6 ENSMUST00000034342.7 ENSMUST00000034342.8 ENSMUST00000034342.9 NM_029295 Q3T9V7 Q8BUC3 Q91ZA4 Q923S4 Q923S5 Q9DAS1 uc009nad.1 uc009nad.2 uc009nad.3 May play an important role in inflammation and regeneration of skeletal muscle (By similarity). Essential for embryonic development (PubMed:34446558). Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=CKLF2; IsoId=Q9DAS1-1; Sequence=Displayed; Name=CKLF3 ; IsoId=Q9DAS1-2; Sequence=VSP_050600, VSP_050602; Name=CKLF4; Synonyms=mCKLF4; IsoId=Q9DAS1-4; Sequence=VSP_050599; Name=CKLF5; IsoId=Q9DAS1-5; Sequence=VSP_050603; Ubiquitous. Mice exhibit embryonic lethality. Belongs to the chemokine-like factor family. Sequence=AAK94042.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; cytokine activity extracellular region extracellular space chemotaxis signal transduction chemokine activity cell proliferation membrane integral component of membrane neutrophil chemotaxis leukocyte chemotaxis secretion by cell macrophage chemotaxis lymphocyte chemotaxis uc009nad.1 uc009nad.2 uc009nad.3 
ENSMUST00000034343.5 Cmtm3 ENSMUST00000034343.5 CKLF-like MARVEL transmembrane domain containing 3 (from RefSeq NM_024217.3) A6H6B5 CKLF3_MOUSE Cklfsf3 ENSMUST00000034343.1 ENSMUST00000034343.2 ENSMUST00000034343.3 ENSMUST00000034343.4 NM_024217 Q8BJU1 Q99LJ5 Q9D165 uc009nam.1 uc009nam.2 Membrane; Multi-pass membrane protein. Belongs to the chemokine-like factor family. Sequence=BAB23056.1; Type=Frameshift; Evidence=; blastocyst hatching cytokine activity protein binding extracellular space cytoplasm chemotaxis signal transduction membrane integral component of membrane nuclear membrane positive regulation of B cell receptor signaling pathway uc009nam.1 uc009nam.2 
ENSMUST00000034344.10 Cmtm2a ENSMUST00000034344.10 CKLF-like MARVEL transmembrane domain containing 2A (from RefSeq NM_027022.4) CLF2A_MOUSE Cklfsf2a ENSMUST00000034344.1 ENSMUST00000034344.2 ENSMUST00000034344.3 ENSMUST00000034344.4 ENSMUST00000034344.5 ENSMUST00000034344.6 ENSMUST00000034344.7 ENSMUST00000034344.8 ENSMUST00000034344.9 NM_027022 Q811V3 Q9CVR4 Q9DAR1 uc009nah.1 uc009nah.2 uc009nah.3 Membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=1b; IsoId=Q9DAR1-1; Sequence=Displayed; Name=2; IsoId=Q9DAR1-2; Sequence=VSP_008255; Name=3; Synonyms=1a; IsoId=Q9DAR1-3; Sequence=VSP_008253, VSP_008254; Name=4; IsoId=Q9DAC0-1; Sequence=External; Belongs to the chemokine-like factor family. transcription corepressor activity cytokine activity protein binding extracellular space nucleus cytoplasm chemotaxis signal transduction membrane integral component of membrane negative regulation of transcription, DNA-templated regulation of testosterone biosynthetic process uc009nah.1 uc009nah.2 uc009nah.3 
ENSMUST00000034346.15 Ces2a ENSMUST00000034346.15 carboxylesterase 2A, transcript variant 1 (from RefSeq NM_133960.5) Ces2a Ces6 E9Q3D0 ENSMUST00000034346.1 ENSMUST00000034346.10 ENSMUST00000034346.11 ENSMUST00000034346.12 ENSMUST00000034346.13 ENSMUST00000034346.14 ENSMUST00000034346.2 ENSMUST00000034346.3 ENSMUST00000034346.4 ENSMUST00000034346.5 ENSMUST00000034346.6 ENSMUST00000034346.7 ENSMUST00000034346.8 ENSMUST00000034346.9 EST2A_MOUSE NM_133960 Q3TMR2 Q8QZR3 uc009nbc.1 uc009nbc.2 uc009nbc.3 uc009nbc.4 Carboxylesterases that catalyzes the hydrolysis of pyrethroids pesticides. Hydrolyzes permethrin faster than cypermethrin. Hydrolyzes retinyl esters (By similarity). Reaction=(-)-trans-permethrin + H2O = (1S,3R)-3-(2,2-dichlorovinyl)- 2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+); Xref=Rhea:RHEA:30283, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:62523, ChEBI:CHEBI:62527, ChEBI:CHEBI:62531; EC=3.1.1.88; Evidence=; Reaction=all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate; Xref=Rhea:RHEA:13933, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13934; Evidence=; Microsome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8QZR3-1; Sequence=Displayed; Name=2; IsoId=Q8QZR3-2; Sequence=VSP_053352; Belongs to the type-B carboxylesterase/lipase family. extracellular space protein glycosylation hydrolase activity carboxylic ester hydrolase activity trans-permethrin hydrolase activity uc009nbc.1 uc009nbc.2 uc009nbc.3 uc009nbc.4 
ENSMUST00000034349.10 Nae1 ENSMUST00000034349.10 NEDD8 activating enzyme E1 subunit 1, transcript variant 1 (from RefSeq NM_144931.3) Appbp1 ENSMUST00000034349.1 ENSMUST00000034349.2 ENSMUST00000034349.3 ENSMUST00000034349.4 ENSMUST00000034349.5 ENSMUST00000034349.6 ENSMUST00000034349.7 ENSMUST00000034349.8 ENSMUST00000034349.9 NM_144931 Q8CFL6 Q8VBW6 ULA1_MOUSE uc009nas.1 uc009nas.2 uc009nas.3 Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity). The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development. Binding of TP53BP2 to the regulatory subunit NAE1 decreases neddylation activity. Protein modification; protein neddylation. Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M. Binds APP and TP53BP2 (By similarity). Cell membrane Note=Colocalizes with APP in lipid rafts. Ubiquitinated by TRIP12, leading to its degradation by the proteasome. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. cytoplasm early endosome plasma membrane apoptotic process cell cycle small protein activating enzyme activity membrane NEDD8 activating enzyme activity ubiquitin protein ligase binding protein modification by small protein conjugation macromolecular complex mitotic DNA replication checkpoint regulation of apoptotic process regulation of neuron apoptotic process protein neddylation membrane raft protein heterodimerization activity neuron apoptotic process uc009nas.1 uc009nas.2 uc009nas.3 
ENSMUST00000034351.8 Rrad ENSMUST00000034351.8 Ras-related associated with diabetes, transcript variant 1 (from RefSeq NM_019662.3) ENSMUST00000034351.1 ENSMUST00000034351.2 ENSMUST00000034351.3 ENSMUST00000034351.4 ENSMUST00000034351.5 ENSMUST00000034351.6 ENSMUST00000034351.7 NM_019662 Q6PGA2 Q6PGA2_MOUSE Rrad uc009naz.1 uc009naz.2 uc009naz.3 Interacts with Calmodulin. Belongs to the small GTPase superfamily. RGK family. nucleotide binding GTPase activity GTP binding signal transduction membrane regulation of high voltage-gated calcium channel activity negative regulation of high voltage-gated calcium channel activity uc009naz.1 uc009naz.2 uc009naz.3 
ENSMUST00000034355.11 Ces2e ENSMUST00000034355.11 carboxylesterase 2E, transcript variant 1 (from RefSeq NM_172759.3) Ces2e Ces5 ENSMUST00000034355.1 ENSMUST00000034355.10 ENSMUST00000034355.2 ENSMUST00000034355.3 ENSMUST00000034355.4 ENSMUST00000034355.5 ENSMUST00000034355.6 ENSMUST00000034355.7 ENSMUST00000034355.8 ENSMUST00000034355.9 EST2E_MOUSE NM_172759 Q8BK48 Q8BM97 Q8VC02 uc009nbg.1 uc009nbg.2 uc009nbg.3 Carboxylesterase that catalyzes the hydrolysis of pyrethroids pesticides. Hydrolyzes trans-permethrin at a rate about 22-fold higher than cis-permethrin. Also hydrolyzes trans-cypermethrin. Hydrolyzes retinyl esters (By similarity). Reaction=(-)-trans-permethrin + H2O = (1S,3R)-3-(2,2-dichlorovinyl)- 2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+); Xref=Rhea:RHEA:30283, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:62523, ChEBI:CHEBI:62527, ChEBI:CHEBI:62531; EC=3.1.1.88; Evidence=; Reaction=all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate; Xref=Rhea:RHEA:13933, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13934; Evidence=; Kinetic parameters: KM=286 uM for p-Nitrophenyl acetate ; KM=0.5 uM for cypermethrin ; KM=2.2 uM for (R/S)-alpha-cyano(6-methoxy-2-naphthyl)-methyl-(R/S)- trans/cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate ; KM=0.89 uM for (R/S)-alpha-cyano(6-methoxy-2-naphthyl)-methyl-(R)- (-)-2-(4-chlorophenyl)-3-methyl butanoate ((alphaR/S)(2R)-A3) ; KM=0.96 uM for chrysanthemic acid ; Note=kcat is 94 sec(-1) with p-Nitrophenyl acetate as substrate. kcat is 0.12 sec(-1) with cypermethrin as substrate. kcat is 0.11 sec(-1) with (R/S)-alpha-cyano(6-methoxy-2-naphthyl)-methyl-(R/S)-trans/cis- 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate as substrate. kcat is 0.067 sec(-1) with (R/S)-alpha-cyano(6-methoxy-2- naphthyl)-methyl-(R)-(-)-2-(4-chlorophenyl)-3-methyl butanoate ((alphaR/S)(2R)-A3) as substrate. kcat is 0.099 sec(-1) with chrysanthemic acid as substrate.; Microsome Glycosylated. Belongs to the type-B carboxylesterase/lipase family. extracellular space endoplasmic reticulum hydrolase activity intracellular membrane-bounded organelle carboxylic ester hydrolase activity trans-permethrin hydrolase activity uc009nbg.1 uc009nbg.2 uc009nbg.3 
ENSMUST00000034359.10 Tradd ENSMUST00000034359.10 TNFRSF1A-associated via death domain (from RefSeq NM_001033161.2) ENSMUST00000034359.1 ENSMUST00000034359.2 ENSMUST00000034359.3 ENSMUST00000034359.4 ENSMUST00000034359.5 ENSMUST00000034359.6 ENSMUST00000034359.7 ENSMUST00000034359.8 ENSMUST00000034359.9 NM_001033161 Q3U0V2 TRADD_MOUSE Tradd uc009nby.1 uc009nby.2 uc009nby.3 Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD (By similarity). Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (PubMed:22561347). Stimulation of TNF-alpha receptor TNFRSF1A leads to the formation of two distinct signaling complexes (PubMed:14585990). Plasma membrane-bound complex I is composed of TNFRSF1A, TRADD, RIPK1, TRAF2 and BIRC2/c-IAP1 or BIRC3 which interacts with CHUCK/IKK-alpha, IKBKB/IKK-beta and IKBKG/IKK-gamma promoting cell survival (PubMed:14585990). Subsequently, TRADD, RIPK1 and TRAF2 dissociate from TNFRSF1A and form cytoplasmic complex II with FADD and caspase CASP8 promoting cell apoptosis (By similarity). Within complex I, interacts with TNFRSF1A/TNFR1, TRAF2 and kinase RIPK1 (By similarity). Within complex I, interacts with TRPC4AP; the interaction promotes NF-kappa B activation (PubMed:14585990). UXT1 associates with complex I; the interaction prevents the formation of complex II (By similarity). Within complex I Interacts with scaffold protein DAB2IP (By similarity). Interacts with autophagy receptor SQSTM1 (By similarity). Interacts with E3 ligase TRIP12 (PubMed:22561347). Interacts with kinase HIPK2 (By similarity). Interacts with keratin KRT14 (PubMed:16702408). Interacts with keratin KRT18 (By similarity). Interacts with KRT16 and KRT17 (PubMed:16702408). Interacts with FADD (PubMed:30185824). Interacts with TOMM70 (By similarity). Q3U0V2; Q60855: Ripk1; NbExp=2; IntAct=EBI-1544032, EBI-529119; Q3U0V2; Q9QUK6: Tlr4; NbExp=3; IntAct=EBI-1544032, EBI-1534575; Q3U0V2; P01375: TNF; Xeno; NbExp=2; IntAct=EBI-1544032, EBI-359977; Nucleus Cytoplasm Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus. Requires the intact death domain to associate with TNFRSF1A/TNFR1. (Microbial infection) Glycosylated at Arg-243 by S.typhimurium protein Ssek1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions and assembly of the oligomeric TNFRSF1A/TNFR1 complex, thereby disrupting TNF signaling. Mice develop tumors. In a C57BL/6 genetic background, mice exhibit a shorter lifespan than wild-type, but exhibit low incidences of observable tumor formation. In the FVB/N background, which is more tumor-prone, mice show a significant increase in the spontaneous development of a broad range of tumor types. transmembrane receptor protein tyrosine kinase adaptor activity tumor necrosis factor receptor binding protein binding nucleus cytoplasm cytoskeleton plasma membrane apoptotic process signal transduction transmembrane receptor protein tyrosine kinase signaling pathway kinase binding positive regulation of cell migration macromolecular complex identical protein binding regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling receptor complex macromolecular complex binding membrane raft positive regulation of inflammatory response positive regulation of NF-kappaB transcription factor activity protein heterooligomerization positive regulation of hair follicle development binding, bridging death domain binding cellular response to tumor necrosis factor extrinsic apoptotic signaling pathway positive regulation of NIK/NF-kappaB signaling uc009nby.1 uc009nby.2 uc009nby.3 
ENSMUST00000034361.10 Phaf1 ENSMUST00000034361.10 phagosome assembly factor 1, transcript variant 3 (from RefSeq NR_166491.1) ENSMUST00000034361.1 ENSMUST00000034361.2 ENSMUST00000034361.3 ENSMUST00000034361.4 ENSMUST00000034361.5 ENSMUST00000034361.6 ENSMUST00000034361.7 ENSMUST00000034361.8 ENSMUST00000034361.9 NR_166491 PHAF1_MOUSE Phaf1 Q6PER2 Q922R1 uc009nbt.1 uc009nbt.2 uc009nbt.3 uc009nbt.4 uc009nbt.5 Plays a regulatory role in autophagic activity. In complex with BCAS3, associates with the autophagosome formation site during both non-selective and selective autophagy. Interacts with BCAS3; the interaction is requrired for the association with the phagophore. Cytoplasm Preautophagosomal structure Note=The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner. Belongs to the PHAF1 family. trans-Golgi network membrane PDZ domain binding dendrite synaptic vesicle membrane glutamate receptor binding Golgi to plasma membrane protein transport uc009nbt.1 uc009nbt.2 uc009nbt.3 uc009nbt.4 uc009nbt.5 
ENSMUST00000034363.7 Hsd11b2 ENSMUST00000034363.7 hydroxysteroid 11-beta dehydrogenase 2 (from RefSeq NM_008289.2) DHI2_MOUSE ENSMUST00000034363.1 ENSMUST00000034363.2 ENSMUST00000034363.3 ENSMUST00000034363.4 ENSMUST00000034363.5 ENSMUST00000034363.6 Hsd11k NM_008289 P51661 Q91WK3 uc009nde.1 uc009nde.2 uc009nde.3 Catalyzes the conversion of biologically active 11beta- hydroxyglucocorticoids (11beta-hydroxysteroid) such as corticosterone, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as 11- dehydrocorticosterone, in the presence of NAD(+) (Probable) (PubMed:30902677, PubMed:22796344). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids (PubMed:7664690). Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure (PubMed:31600723). Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen (PubMed:22796344). Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone (By similarity). Converts 7- beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro (By similarity). 7-beta-25-dihydroxycholesterol (not 7-oxo-25- hydroxycholesterol) acts as a ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity). Reaction=an 11beta-hydroxysteroid + NAD(+) = an 11-oxosteroid + H(+) + NADH; Xref=Rhea:RHEA:53116, ChEBI:CHEBI:15378, ChEBI:CHEBI:35346, ChEBI:CHEBI:47787, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53117; Evidence= Reaction=corticosterone + NAD(+) = 11-dehydrocorticosterone + H(+) + NADH; Xref=Rhea:RHEA:42204, ChEBI:CHEBI:15378, ChEBI:CHEBI:16827, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78600; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42205; Evidence= Reaction=11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) = 17beta- hydroxyandrost-4-ene-3,11-dione + H(+) + NADH; Xref=Rhea:RHEA:69368, ChEBI:CHEBI:15378, ChEBI:CHEBI:34133, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:81481; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69369; Evidence=; Reaction=11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) = androst-4- ene-3,11,17-trione + H(+) + NADH; Xref=Rhea:RHEA:69408, ChEBI:CHEBI:2495, ChEBI:CHEBI:15378, ChEBI:CHEBI:27967, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69409; Evidence=; Inhibited by glycyrrhetinic acid (By similarity). Induced by progesterone, through the Ihh signaling pathway (PubMed:31600723). Kinetic parameters: KM=24 nM for corticosterone ; KM=33 nM for 11beta,17beta-dihydroxyandrost-4-ene-3-one ; KM=44 nM for cortisol ; Steroid metabolism. Interacts with ligand-free cytoplasmic NR3C2. Microsome Endoplasmic reticulum Highly expressed in kidney (PubMed:7664690). Also found in colon and small intestine (PubMed:7664690). Not expressed in the adrenal gland (PubMed:7664690). Expressed in uterus (PubMed:31600723). Expression (mRNA and protein) is highest in uteri on days 3 and 4 during early pregnancy. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Rats and mice do not produce appreciable cortisol, because they do not express the 17-alpha hydroxylase (Cyp17a1) enzyme in the adrenals. Sequence=CAA62219.1; Type=Frameshift; Evidence=; response to hypoxia regulation of blood volume by renal aldosterone 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity steroid binding cytoplasm endoplasmic reticulum female pregnancy glucocorticoid metabolic process oxidoreductase activity response to food response to insulin response to drug intracellular membrane-bounded organelle response to steroid hormone NAD binding response to glucocorticoid oxidation-reduction process uc009nde.1 uc009nde.2 uc009nde.3 
ENSMUST00000034365.5 Tsnaxip1 ENSMUST00000034365.5 translin-associated factor X (Tsnax) interacting protein 1 (from RefSeq NM_024445.4) ENSMUST00000034365.1 ENSMUST00000034365.2 ENSMUST00000034365.3 ENSMUST00000034365.4 NM_024445 Q99P25 Q9DA98 TXIP1_MOUSE Tsnaxip1 Txi1 uc009nee.1 uc009nee.2 Possible role in spermatogenesis. Interacts with TSNAX. Cytoplasm, perinuclear region Specifically expressed in testes. Predominantly detected in the post-meiotic stages of germ cells. Sequence=AAK13524.1; Type=Erroneous initiation; Evidence=; protein binding cytoplasm multicellular organism development spermatogenesis biological_process cell differentiation perinuclear region of cytoplasm uc009nee.1 uc009nee.2 
ENSMUST00000034368.8 Ctrl ENSMUST00000034368.8 chymotrypsin-like (from RefSeq NM_023182.2) Ctra1 Ctrl ENSMUST00000034368.1 ENSMUST00000034368.2 ENSMUST00000034368.3 ENSMUST00000034368.4 ENSMUST00000034368.5 ENSMUST00000034368.6 ENSMUST00000034368.7 NM_023182 Q9ER05 Q9ER05_MOUSE mFLJ00366 uc009neo.1 uc009neo.2 uc009neo.3 serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009neo.1 uc009neo.2 uc009neo.3 
ENSMUST00000034369.10 Psmb10 ENSMUST00000034369.10 proteasome (prosome, macropain) subunit, beta type 10 (from RefSeq NM_013640.3) ENSMUST00000034369.1 ENSMUST00000034369.2 ENSMUST00000034369.3 ENSMUST00000034369.4 ENSMUST00000034369.5 ENSMUST00000034369.6 ENSMUST00000034369.7 ENSMUST00000034369.8 ENSMUST00000034369.9 Lmp10 Mecl1 NM_013640 O08687 O35955 PSB10_MOUSE Q99KC5 uc009nep.1 uc009nep.2 uc009nep.3 uc009nep.4 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Plays a role in determining the T-cell repertoire for an antiviral T-cell response. Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB7. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Cytoplasm Nucleus Detected in liver (at protein level). Up-regulated by interferon gamma (at protein level). Up- regulated by IRF1. Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity. Impaired response of cytotoxic T-lymphocyte (CTL) to dominant epitopes of lymphocytic choriomeningitis virus (LCMV). Belongs to the peptidase T1B family. proteasome complex cell morphogenesis immune system process endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteolysis peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, beta-subunit complex T cell proliferation proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process spermatoproteasome complex uc009nep.1 uc009nep.2 uc009nep.3 uc009nep.4 
ENSMUST00000034370.17 Slc12a4 ENSMUST00000034370.17 solute carrier family 12, member 4, transcript variant 3 (from RefSeq NR_045594.1) ENSMUST00000034370.1 ENSMUST00000034370.10 ENSMUST00000034370.11 ENSMUST00000034370.12 ENSMUST00000034370.13 ENSMUST00000034370.14 ENSMUST00000034370.15 ENSMUST00000034370.16 ENSMUST00000034370.2 ENSMUST00000034370.3 ENSMUST00000034370.4 ENSMUST00000034370.5 ENSMUST00000034370.6 ENSMUST00000034370.7 ENSMUST00000034370.8 ENSMUST00000034370.9 F8WIJ0 F8WIJ0_MOUSE NR_045594 Slc12a4 uc009nes.1 uc009nes.2 uc009nes.3 uc009nes.4 Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out); Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the SLC12A transporter family. ion transport cation:chloride symporter activity potassium:chloride symporter activity membrane integral component of membrane protein kinase binding transmembrane transporter activity transmembrane transport potassium ion transmembrane transport chloride transmembrane transport uc009nes.1 uc009nes.2 uc009nes.3 uc009nes.4 
ENSMUST00000034371.9 Dpep3 ENSMUST00000034371.9 dipeptidase 3 (from RefSeq NM_027960.2) DPEP3_MOUSE ENSMUST00000034371.1 ENSMUST00000034371.2 ENSMUST00000034371.3 ENSMUST00000034371.4 ENSMUST00000034371.5 ENSMUST00000034371.6 ENSMUST00000034371.7 ENSMUST00000034371.8 Mbd3 NM_027960 Q9DA79 uc009net.1 uc009net.2 uc009net.3 Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine (PubMed:32325220). The absence of activity may be due to the inability of serine (instead of aspartate found in DPEP1/2) at position 356 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide (PubMed:32325220). Does not hydrolyze leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed:12738806). Does not hydrolyze the beta-lactam antibiotic imipenem (By similarity). Homodimer; disulfide-linked (By similarity). Interacts with TEX101; co-localized on the cell surface of spermatocytes, spermatids, and testicular spermatozoa, co-localized only in cytoplasmic droplets of caput and corpus epididymal sperm (PubMed:21724266). Membrane ; Lipid- anchor, GPI-anchor Expressed in testis but not ovary. Expressed in ovary and testis at 15.5 dpc. No visible phenotype. Mice are fertile despite a significant reduction in sperm count. Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. According to PubMed:12738806, exhibits dipeptidase activity hydrolyzing cystinyl-bis-glycine but according to PubMed:32325220, lacks this activity which may be due to the inability of serine (instead of aspartate found in DPEP1/2) at position 356 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide. acrosomal vesicle protein binding plasma membrane proteolysis male meiosis peptidase activity metalloexopeptidase activity metallopeptidase activity dipeptidyl-peptidase activity membrane hydrolase activity dipeptidase activity anchored component of membrane metal ion binding meiotic cell cycle uc009net.1 uc009net.2 uc009net.3 
ENSMUST00000034373.8 Dpep2 ENSMUST00000034373.8 dipeptidase 2, transcript variant 1 (from RefSeq NM_001301204.1) DPEP2_MOUSE ENSMUST00000034373.1 ENSMUST00000034373.2 ENSMUST00000034373.3 ENSMUST00000034373.4 ENSMUST00000034373.5 ENSMUST00000034373.6 ENSMUST00000034373.7 Mbd2 NM_001301204 Q3TAV9 Q3TBF7 Q3TBK3 Q3TBM9 Q7TQ53 Q8C255 uc292cxy.1 uc292cxy.2 Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed:12738806). Hydrolyzes cystinyl-bis- glycine (By similarity). Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappa-B inflammatory signaling pathway. Reaction=an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid; Xref=Rhea:RHEA:48940, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869, ChEBI:CHEBI:77460; EC=3.4.13.19; Evidence= Reaction=H2O + leukotriene D4 = glycine + leukotriene E4; Xref=Rhea:RHEA:48616, ChEBI:CHEBI:15377, ChEBI:CHEBI:57305, ChEBI:CHEBI:57462, ChEBI:CHEBI:63166; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48617; Evidence=; Reaction=2 H2O + L-cystine-bis-glycine = 2 glycine + L-cystine; Xref=Rhea:RHEA:60520, ChEBI:CHEBI:15377, ChEBI:CHEBI:35491, ChEBI:CHEBI:57305, ChEBI:CHEBI:143812; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Inhibited by L-penicillamine. Kinetic parameters: KM=5 uM for LTD4 ; Homodimer; disulfide-linked. Membrane ; Lipid- anchor, GPI-anchor Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C255-1; Sequence=Displayed; Name=2; IsoId=Q8C255-2; Sequence=VSP_017853, VSP_017854, VSP_017855; Name=3; IsoId=Q8C255-3; Sequence=VSP_017852; Expressed in heart, lung, testis, spleen and skeletal muscle. Not detected in kidney and brain. Up-regulated during CVB3-induced viral myocarditis in the cardiac infiltrating macrophages. Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. According to PubMed:12738806, does not hydrolyze cystinyl-bis- glycine but data is not shown in paper. cellular_component proteolysis peptidase activity metalloexopeptidase activity metallopeptidase activity exopeptidase activity dipeptidyl-peptidase activity membrane hydrolase activity dipeptidase activity anchored component of membrane metal ion binding uc292cxy.1 uc292cxy.2 
ENSMUST00000034375.11 Dus2 ENSMUST00000034375.11 dihydrouridine synthase 2, transcript variant 1 (from RefSeq NM_025518.4) DUS2L_MOUSE Dus2l ENSMUST00000034375.1 ENSMUST00000034375.10 ENSMUST00000034375.2 ENSMUST00000034375.3 ENSMUST00000034375.4 ENSMUST00000034375.5 ENSMUST00000034375.6 ENSMUST00000034375.7 ENSMUST00000034375.8 ENSMUST00000034375.9 NM_025518 Q6PDX2 Q9D7B1 uc009nfa.1 uc009nfa.2 uc009nfa.3 uc009nfa.4 Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Reaction=5,6-dihydrouridine(20) in tRNA + NADP(+) = H(+) + NADPH + uridine(20) in tRNA; Xref=Rhea:RHEA:53336, Rhea:RHEA-COMP:13533, Rhea:RHEA-COMP:13534, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:65315, ChEBI:CHEBI:74443; EC=1.3.1.91; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:53338; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Interacts with EPRS1. Interacts (via DRBM domain) with PRKRA and EIF2AK2/PKR (via DRBM 1 domain). Cytoplasm Endoplasmic reticulum Note=Mainly at the endoplasmic reticulum. Efficient dihydrouridine synthesis requires the presence of both the catalytic domain and the C-terminal RNA-binding DRBM domain. Belongs to the Dus family. Dus2 subfamily. tRNA dihydrouridine synthesis RNA binding double-stranded RNA binding catalytic activity protein kinase inhibitor activity cytoplasm mitochondrion endoplasmic reticulum cytosol negative regulation of protein kinase activity tRNA processing FMN binding oxidoreductase activity tRNA dihydrouridine synthase activity flavin adenine dinucleotide binding oxidation-reduction process negative regulation of cell death NADPH binding tRNA-dihydrouridine20 synthase activity uc009nfa.1 uc009nfa.2 uc009nfa.3 uc009nfa.4 
ENSMUST00000034377.8 Pla2g15 ENSMUST00000034377.8 phospholipase A2, group XV, transcript variant 1 (from RefSeq NM_133792.3) ENSMUST00000034377.1 ENSMUST00000034377.2 ENSMUST00000034377.3 ENSMUST00000034377.4 ENSMUST00000034377.5 ENSMUST00000034377.6 ENSMUST00000034377.7 Lypla3 NM_133792 PAG15_MOUSE Pla2g15 Q3TCB1 Q3U303 Q8VEB4 uc009nfj.1 uc009nfj.2 Has dual calcium-independent phospholipase and O- acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:16837646, PubMed:17626977, PubMed:11790796, PubMed:16106046, PubMed:16880524, PubMed:19017977, PubMed:20410020). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O- acyltransferase activity). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines (PubMed:20410020). Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (PubMed:16837646, PubMed:17626977). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (PubMed:16837646, PubMed:17626977). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress (PubMed:27993948). Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (PubMed:16880524, PubMed:19017977). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18690; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:38783, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73001, ChEBI:CHEBI:76071; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38784; Evidence=; Reaction=1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:62480, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:77756, ChEBI:CHEBI:145781; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62481; Evidence=; Reaction=1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:62464, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:78207, ChEBI:CHEBI:145780; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62465; Evidence=; Reaction=1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:62484, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:77890, ChEBI:CHEBI:145782; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62485; Evidence=; Reaction=1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:62488, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:61042, ChEBI:CHEBI:145783; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62489; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15178; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N- (acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine; Xref=Rhea:RHEA:38827, ChEBI:CHEBI:46979, ChEBI:CHEBI:73007, ChEBI:CHEBI:76077, ChEBI:CHEBI:76088; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38828; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z- octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero- 3-phosphoethanolamine; Xref=Rhea:RHEA:38823, ChEBI:CHEBI:46979, ChEBI:CHEBI:73004, ChEBI:CHEBI:73007, ChEBI:CHEBI:76054; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38824; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N- (acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3- phosphoethanolamine; Xref=Rhea:RHEA:38831, ChEBI:CHEBI:46979, ChEBI:CHEBI:73008, ChEBI:CHEBI:76077, ChEBI:CHEBI:76090; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38832; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z- octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero- 3-phosphoethanolamine; Xref=Rhea:RHEA:38835, ChEBI:CHEBI:46979, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008, ChEBI:CHEBI:76086; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38836; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N- (acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:38843, ChEBI:CHEBI:46979, ChEBI:CHEBI:73009, ChEBI:CHEBI:76077, ChEBI:CHEBI:76091; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38844; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:38839, ChEBI:CHEBI:46979, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009, ChEBI:CHEBI:76080; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38840; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4- enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38759, ChEBI:CHEBI:46979, ChEBI:CHEBI:73001, ChEBI:CHEBI:76071, ChEBI:CHEBI:76077; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38760; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing- 4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38755, ChEBI:CHEBI:46979, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001, ChEBI:CHEBI:76054; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38756; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N- (acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine; Xref=Rhea:RHEA:38811, ChEBI:CHEBI:46979, ChEBI:CHEBI:73002, ChEBI:CHEBI:76077, ChEBI:CHEBI:76084; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38812; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z- octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero- 3-phosphocholine; Xref=Rhea:RHEA:38807, ChEBI:CHEBI:46979, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002, ChEBI:CHEBI:76086; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38808; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N- (acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phosphocholine; Xref=Rhea:RHEA:38775, ChEBI:CHEBI:46979, ChEBI:CHEBI:73003, ChEBI:CHEBI:76077, ChEBI:CHEBI:76079; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38776; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn- glycero-3-phosphocholine; Xref=Rhea:RHEA:38771, ChEBI:CHEBI:46979, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003, ChEBI:CHEBI:76080; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38772; Evidence=; Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1- hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z- docosahexaenoyl)-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38815, ChEBI:CHEBI:46979, ChEBI:CHEBI:74963, ChEBI:CHEBI:76077, ChEBI:CHEBI:76085; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38816; Evidence=; Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1- (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38819, ChEBI:CHEBI:46979, ChEBI:CHEBI:72998, ChEBI:CHEBI:74963, ChEBI:CHEBI:76087; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38820; Evidence=; Reaction=1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N- (acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:62472, ChEBI:CHEBI:46979, ChEBI:CHEBI:76077, ChEBI:CHEBI:78207, ChEBI:CHEBI:145780; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62473; Evidence=; Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4- enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38799, ChEBI:CHEBI:46979, ChEBI:CHEBI:75034, ChEBI:CHEBI:76071, ChEBI:CHEBI:76074; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38800; Evidence=; Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing- 4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38795, ChEBI:CHEBI:46979, ChEBI:CHEBI:73858, ChEBI:CHEBI:75034, ChEBI:CHEBI:76054; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38796; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3- phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z- octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero- 3-phosphocholine; Xref=Rhea:RHEA:57108, ChEBI:CHEBI:46979, ChEBI:CHEBI:73858, ChEBI:CHEBI:76086, ChEBI:CHEBI:84822; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57109; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N- (acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phosphocholine; Xref=Rhea:RHEA:57120, ChEBI:CHEBI:46979, ChEBI:CHEBI:74965, ChEBI:CHEBI:76074, ChEBI:CHEBI:76079; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57121; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn- glycero-3-phosphocholine; Xref=Rhea:RHEA:57116, ChEBI:CHEBI:46979, ChEBI:CHEBI:73858, ChEBI:CHEBI:74965, ChEBI:CHEBI:76080; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57117; Evidence=; Reaction=1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing- 4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38767, ChEBI:CHEBI:46979, ChEBI:CHEBI:74667, ChEBI:CHEBI:76054, ChEBI:CHEBI:76078; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38768; Evidence=; Reaction=1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine; Xref=Rhea:RHEA:38763, ChEBI:CHEBI:28610, ChEBI:CHEBI:46979, ChEBI:CHEBI:74667, ChEBI:CHEBI:76077; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38764; Evidence=; Reaction=1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing- 4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38791, ChEBI:CHEBI:46979, ChEBI:CHEBI:76054, ChEBI:CHEBI:76073, ChEBI:CHEBI:76076; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38792; Evidence=; Reaction=1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine; Xref=Rhea:RHEA:38803, ChEBI:CHEBI:28610, ChEBI:CHEBI:46979, ChEBI:CHEBI:76073, ChEBI:CHEBI:76074; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38804; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N- (acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4- enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38703, ChEBI:CHEBI:28610, ChEBI:CHEBI:46979, ChEBI:CHEBI:74669, ChEBI:CHEBI:76054; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38704; Evidence=; Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L- serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)- sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine; Xref=Rhea:RHEA:57140, ChEBI:CHEBI:46979, ChEBI:CHEBI:76074, ChEBI:CHEBI:77342, ChEBI:CHEBI:78260; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57141; Evidence=; Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L- serine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)- sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine; Xref=Rhea:RHEA:57136, ChEBI:CHEBI:46979, ChEBI:CHEBI:76054, ChEBI:CHEBI:78260, ChEBI:CHEBI:84467; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57137; Evidence=; Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'- sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)- sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn- glycerol); Xref=Rhea:RHEA:57144, ChEBI:CHEBI:46979, ChEBI:CHEBI:72845, ChEBI:CHEBI:76074, ChEBI:CHEBI:141490; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57145; Evidence=; Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'- sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N- (acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn- glycerol); Xref=Rhea:RHEA:57148, ChEBI:CHEBI:46979, ChEBI:CHEBI:72827, ChEBI:CHEBI:72845, ChEBI:CHEBI:76054; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57149; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (9Z-octadecenoyl)-sn- glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)- eicosatetraenoylamino]ethyl (9Z)-octadecenoate; Xref=Rhea:RHEA:38751, ChEBI:CHEBI:2700, ChEBI:CHEBI:74669, ChEBI:CHEBI:76070, ChEBI:CHEBI:76083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38752; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z- octadecenoyl) ethanolamine = (9Z-octadecenoyl)-sn-glycero-3- phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate; Xref=Rhea:RHEA:38747, ChEBI:CHEBI:71466, ChEBI:CHEBI:74669, ChEBI:CHEBI:76068, ChEBI:CHEBI:76083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38748; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z- octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3- phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol; Xref=Rhea:RHEA:38743, ChEBI:CHEBI:74669, ChEBI:CHEBI:75735, ChEBI:CHEBI:75938, ChEBI:CHEBI:76083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38744; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z- octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3- phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol; Xref=Rhea:RHEA:38739, ChEBI:CHEBI:74669, ChEBI:CHEBI:75735, ChEBI:CHEBI:75757, ChEBI:CHEBI:76083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38740; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2- hexadecanoylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol; Xref=Rhea:RHEA:38735, ChEBI:CHEBI:74669, ChEBI:CHEBI:75455, ChEBI:CHEBI:76065, ChEBI:CHEBI:76083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38736; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3- hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3- phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol; Xref=Rhea:RHEA:38731, ChEBI:CHEBI:64757, ChEBI:CHEBI:74669, ChEBI:CHEBI:75867, ChEBI:CHEBI:76083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38732; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38699, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669, ChEBI:CHEBI:76083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38700; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O- hexadecyl-2-acetyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3- phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn- glycerol; Xref=Rhea:RHEA:38707, ChEBI:CHEBI:74669, ChEBI:CHEBI:75936, ChEBI:CHEBI:76055, ChEBI:CHEBI:76083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38708; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O- hexadecylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol; Xref=Rhea:RHEA:38711, ChEBI:CHEBI:74669, ChEBI:CHEBI:76061, ChEBI:CHEBI:76062, ChEBI:CHEBI:76083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38712; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O- hexadecyl-2-O-methyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3- phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn- glycerol; Xref=Rhea:RHEA:38723, ChEBI:CHEBI:74669, ChEBI:CHEBI:76063, ChEBI:CHEBI:76064, ChEBI:CHEBI:76083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38724; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1- hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3- phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol; Xref=Rhea:RHEA:38727, ChEBI:CHEBI:74669, ChEBI:CHEBI:75542, ChEBI:CHEBI:75868, ChEBI:CHEBI:76083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38728; Evidence=; Phospholipase sn-2 versus sn-1 positional specificity is affected by the phospholipid composition of membranes. Phospholipase A2 activity toward 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphocholine (PAPE) is enhanced in the presence of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), which promotes lipid bilayer formation (PubMed:16837646). O-acyltransferase activity is inhibited by antiarrhythmic drug amiodarone (PubMed:27993948). Kinetic parameters: KM=171 uM for 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine (O-acyltransferase activity) ; Vmax=5.55 umol/min/mg enzyme toward 1,2-di-(9Z-octadecenoyl)-sn- glycero-3-phosphocholine (O-acyltransferase activity) ; pH dependence: Optimum pH is 4.5. ; Secreted sosome Membrane ; Peripheral membrane protein Detected in blood plasma (PubMed:20410020). Detected in alveolar macrophages (at protein level) (PubMed:16106046, PubMed:16880524, PubMed:19017977). Detected in heart, liver, spleen, kidney, thymus, brain and lung (PubMed:16880524). N-glycosylated (PubMed:11790796). N-glycosylation is important for maturation of the enzyme and normal subcellular location (By similarity). Mice are born at the expected Mendelian rate, are viable and fertile. They display strongly reduced transacylase activity in lung alveolar macrophages and in peritoneal macrophages, leading to the accumulation of pulmonary surfactant phospholipids with phosphatidylethanolamine and phosphatidylcholine headgroups. Mice display higher numers of alveolar macrophages in the lung, together with a mononuclear cell infiltrate in airways and blood vessels. Alveolar nmacrophages are larger than normal and present lamellar inclusion bodies, indicative of cellular phospholipidosis. Besides, mutant mice display splenomegaly. Belongs to the AB hydrolase superfamily. Lipase family. extracellular region extracellular space nucleoplasm mitochondrion lysosome lipid metabolic process fatty acid metabolic process glycerophospholipid metabolic process ceramide metabolic process O-acyltransferase activity membrane transferase activity transferase activity, transferring acyl groups hydrolase activity phosphatidylcholine catabolic process intracellular membrane-bounded organelle phosphatidylethanolamine catabolic process phosphatidylcholine metabolic process calcium-independent phospholipase A2 activity lysophospholipase activity uc009nfj.1 uc009nfj.2 
ENSMUST00000034378.5 Slc7a6 ENSMUST00000034378.5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6, transcript variant 3 (from RefSeq NR_151677.1) ENSMUST00000034378.1 ENSMUST00000034378.2 ENSMUST00000034378.3 ENSMUST00000034378.4 Kiaa0245 NR_151677 Q3TMY5 Q3U084 Q6ZQF5 Q8BGK6 Q8CFY3 Slc7a6 YLAT2_MOUSE uc009nfm.1 uc009nfm.2 uc009nfm.3 Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (By similarity). Also exchanges L-arginine with L-lysine in a sodium-independent manner (By similarity). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). Contributes to ammonia- induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (By similarity). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (PubMed:24599290). Reaction=L-arginine(in) + L-lysine(out) = L-arginine(out) + L- lysine(in); Xref=Rhea:RHEA:70827, ChEBI:CHEBI:32551, ChEBI:CHEBI:32682; Evidence=; Reaction=L-arginine(in) + L-leucine(out) + Na(+)(out) = L-arginine(out) + L-leucine(in) + Na(+)(in); Xref=Rhea:RHEA:70831, ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:57427; Evidence=; Reaction=L-arginine(in) + L-glutamine(out) + Na(+)(out) = L- arginine(out) + L-glutamine(in) + Na(+)(in); Xref=Rhea:RHEA:70835, ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:58359; Evidence=; Reaction=L-arginine(in) + L-histidine(out) + Na(+)(out) = L- arginine(out) + L-histidine(in) + Na(+)(in); Xref=Rhea:RHEA:70839, ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:57595; Evidence=; Reaction=L-arginine(in) + L-cysteine(out) + Na(+)(out) = L- arginine(out) + L-cysteine(in) + Na(+)(in); Xref=Rhea:RHEA:70847, ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:35235; Evidence=; Reaction=L-arginine(in) + L-methionine(out) + Na(+)(out) = L- arginine(out) + L-methionine(in) + Na(+)(in); Xref=Rhea:RHEA:70843, ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:57844; Evidence=; Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8BGK6-1; Sequence=Displayed; Name=2 ; IsoId=Q8BGK6-2; Sequence=VSP_052833, VSP_052834; Strongest expression in brain but also detected in testis, parotis, small intestine, heart and kidney. Weakly expressed in spleen, lung and liver. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. Sequence=AAH38404.1; Type=Frameshift; Evidence=; Sequence=BAC97909.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; plasma membrane amino acid transport L-amino acid transmembrane transporter activity antiporter activity membrane integral component of membrane basolateral plasma membrane transmembrane transporter activity intracellular membrane-bounded organelle transmembrane transport L-alpha-amino acid transmembrane transport uc009nfm.1 uc009nfm.2 uc009nfm.3 
ENSMUST00000034382.8 Zfp90 ENSMUST00000034382.8 zinc finger protein 90, transcript variant 2 (from RefSeq NM_011764.4) ENSMUST00000034382.1 ENSMUST00000034382.2 ENSMUST00000034382.3 ENSMUST00000034382.4 ENSMUST00000034382.5 ENSMUST00000034382.6 ENSMUST00000034382.7 NM_011764 Nk10 Q3U4J5 Q543I6 Q61967 ZFP90_MOUSE uc009ngd.1 uc009ngd.2 Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. Interacts (via N- and C-termini) with REST (via zinc-finger DNA-binding domain); the interaction inhibits REST repressor activity. Nucleus te=Colocalizes with REST in the nucleus. Brain, spleen, thymus, and testis (PubMed:7576184). Expressed in heart (PubMed:7576184, PubMed:21284946). There is a marked increase after postnatal stages 18-20 (simultaneously to the appearance of haploid cell stages). Maximal expression is observed around 2 weeks postnatally, with the exception of brain and testis, where the expression is highest in earlier developmental stages. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAE32436.1; Type=Frameshift; Evidence=; Sequence=BAE32436.1; Type=Miscellaneous discrepancy; Note=After frameshift's correction, the CDS was not identified.; Evidence=; negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated negative regulation of DNA binding sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated metal ion binding uc009ngd.1 uc009ngd.2 
ENSMUST00000034385.12 Has3 ENSMUST00000034385.12 hyaluronan synthase 3, transcript variant 1 (from RefSeq NM_008217.4) ENSMUST00000034385.1 ENSMUST00000034385.10 ENSMUST00000034385.11 ENSMUST00000034385.2 ENSMUST00000034385.3 ENSMUST00000034385.4 ENSMUST00000034385.5 ENSMUST00000034385.6 ENSMUST00000034385.7 ENSMUST00000034385.8 ENSMUST00000034385.9 HYAS3_MOUSE NM_008217 O08650 Q8CEB9 uc012gjw.1 uc012gjw.2 Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis. Reaction=[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N- acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP; Xref=Rhea:RHEA:20465, Rhea:RHEA-COMP:12583, Rhea:RHEA-COMP:12585, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:132153, ChEBI:CHEBI:132154; EC=2.4.1.212; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20466; Evidence=; Reaction=N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP- alpha-D-glucuronate = [hyaluronan](n+1) + H(+) + UDP; Xref=Rhea:RHEA:12528, Rhea:RHEA-COMP:12585, Rhea:RHEA-COMP:12587, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132153, ChEBI:CHEBI:132154; EC=2.4.1.212; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12529; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Kinetic parameters: KM=0.2 mM for UDP-Glc-NAc (at pH 7.1 and 37 degrees Celsius, in the presence of 15 mM MgCl2) ; KM=0.3 mM for UDP-Glc-UA (at pH 7.1 and 37 degrees Celsius, in the presence of 15 mM MgCl2) ; Glycan biosynthesis; hyaluronan biosynthesis. Cell membrane ulti-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Cytoplasmic vesicle Note=Travels through endoplasmic reticulum (ER), Golgi, plasma membrane, and endocytic vesicles (PubMed:16014622). Actives only when present in plasma membrane (PubMed:16014622). O-GlcNAcylation controls its membrane localization (By similarity). A rapid recycling of HAS3 between plasma membrane and endosomes is controlled by the cytosolic levels of UDP-GlcUA and UDP- GlcNAc (By similarity). Expressed at 17.5 dpc. O-GlcNAcylation increases the hyaluronan synthase activity, HAS3 stability and its plasma membrane residence. The concentration of UDP- GlcNAc controls the level of O-GlcNAc modification. Deficient mice are viable and fertile however absence of HAS3 increases the excitability of neural networks and drives the formation of epileptic seizures. Belongs to the NodC/HAS family. cytoplasm integral component of plasma membrane membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups hyaluronan biosynthetic process hyaluranon cable identical protein binding extracellular polysaccharide biosynthetic process positive regulation of transcription, DNA-templated hyaluronan synthase activity extracellular matrix assembly positive regulation of hyaluranon cable assembly uc012gjw.1 uc012gjw.2 
ENSMUST00000034388.10 Vps4a ENSMUST00000034388.10 vacuolar protein sorting 4A (from RefSeq NM_126165.2) ENSMUST00000034388.1 ENSMUST00000034388.2 ENSMUST00000034388.3 ENSMUST00000034388.4 ENSMUST00000034388.5 ENSMUST00000034388.6 ENSMUST00000034388.7 ENSMUST00000034388.8 ENSMUST00000034388.9 NM_126165 Q3TXT2 Q8VEJ9 VPS4A_MOUSE Vps4a uc009ngv.1 uc009ngv.2 uc009ngv.3 Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization and chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase (By similarity). In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Critical for normal erythroblast cytokinesis and correct erythropoiesis (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.6; Evidence=; Proposed to be monomeric or homodimeric in nucleotide-free form and to oligomerize upon binding to ATP to form two stacked hexameric or heptameric rings with a central pore through which ESCRT- III substrates are translocated in an ATP-dependent manner (By similarity). Interacts with CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP6. Interacts with VPS4B; the interaction suggests a heteromeric assembly with VPS4B. Interacts with SPAST. Interacts with IST1. Interacts with ZFYVE19/ANCHR; leading to retain it at midbody (By similarity). Late endosome membrane ; Peripheral membrane protein Midbody Cytoplasm, cytoskeleton, spindle Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells, interaction with ZFYVE19/ANCHR mediates retention at midbody. Localized in two distinct rings on either side of the Flemming body (By similarity). Highly expressed in testis and moderately in heart and brain. Not detected in spleen, lung, liver, skeletal muscle or kidney. The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle that binds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subset of ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along the groove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2) (By similarity). Belongs to the AAA ATPase family. nucleotide binding spindle pole protein binding ATP binding nucleus cytoplasm lysosome endosome early endosome late endosome vacuolar membrane centrosome cytosol plasma membrane protein targeting to lysosome membrane budding nucleus organization vacuole organization cell cycle mitotic metaphase plate congression protein C-terminus binding abscission endosome membrane protein transport membrane vesicle-mediated transport endosomal transport hydrolase activity ATPase activity Rho GTPase binding viral release from host cell protein domain specific binding midbody late endosome membrane intracellular cholesterol transport negative regulation of cytokinesis regulation of protein localization endosomal vesicle fusion multivesicular body assembly viral budding via host ESCRT complex ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway macromolecular complex binding mitotic cytokinesis checkpoint perinuclear region of cytoplasm positive regulation of viral process cell division late endosomal microautophagy vesicle uncoating Flemming body ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway positive regulation of viral release from host cell regulation of protein localization to plasma membrane positive regulation of exosomal secretion positive regulation of viral budding via host ESCRT complex positive regulation of viral life cycle uc009ngv.1 uc009ngv.2 uc009ngv.3 
ENSMUST00000034392.13 Nip7 ENSMUST00000034392.13 NIP7, nucleolar pre-rRNA processing protein, transcript variant 3 (from RefSeq NR_028367.1) ENSMUST00000034392.1 ENSMUST00000034392.10 ENSMUST00000034392.11 ENSMUST00000034392.12 ENSMUST00000034392.2 ENSMUST00000034392.3 ENSMUST00000034392.4 ENSMUST00000034392.5 ENSMUST00000034392.6 ENSMUST00000034392.7 ENSMUST00000034392.8 ENSMUST00000034392.9 NIP7_MOUSE NR_028367 Q9CXK8 Q9D1B4 uc009ngz.1 uc009ngz.2 uc009ngz.3 uc009ngz.4 Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly. Monomer. Interacts with pre-ribosome complex. May bind to RNA. Interacts with NOL8. Interacts with FTSJ3 (By similarity). Nucleus, nucleolus Belongs to the NIP7 family. RNA binding nucleus nucleolus cytosol preribosome, large subunit precursor ribosome biogenesis ribosome assembly ribosomal large subunit biogenesis uc009ngz.1 uc009ngz.2 uc009ngz.3 uc009ngz.4 
ENSMUST00000034393.7 Tmed6 ENSMUST00000034393.7 transmembrane p24 trafficking protein 6 (from RefSeq NM_025458.2) ENSMUST00000034393.1 ENSMUST00000034393.2 ENSMUST00000034393.3 ENSMUST00000034393.4 ENSMUST00000034393.5 ENSMUST00000034393.6 NM_025458 Q9CQG0 TMED6_MOUSE uc009nha.1 uc009nha.2 uc009nha.3 Endoplasmic reticulum membrane ; Single-pass type I membrane protein Belongs to the EMP24/GP25L family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus intracellular protein transport ER to Golgi vesicle-mediated transport Golgi organization membrane integral component of membrane ER to Golgi transport vesicle uc009nha.1 uc009nha.2 uc009nha.3 
ENSMUST00000034396.14 Mtmr2 ENSMUST00000034396.14 myotubularin related protein 2, transcript variant 1 (from RefSeq NM_023858.4) B8JJF4 ENSMUST00000034396.1 ENSMUST00000034396.10 ENSMUST00000034396.11 ENSMUST00000034396.12 ENSMUST00000034396.13 ENSMUST00000034396.2 ENSMUST00000034396.3 ENSMUST00000034396.4 ENSMUST00000034396.5 ENSMUST00000034396.6 ENSMUST00000034396.7 ENSMUST00000034396.8 ENSMUST00000034396.9 MTMR2_MOUSE NM_023858 Q8VHA7 Q9Z2D1 uc012god.1 uc012god.2 uc012god.3 Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:12045210, PubMed:16399794). Has phosphatase activity towards pho sphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate (PubMed:12045210, PubMed:16399794). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5- trisphosphate (PubMed:12045210, PubMed:16399794). Stabilizes SBF2/MTMR13 at the membranes (PubMed:23297362). Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (PubMed:23297362). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3- phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:39019, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57795, ChEBI:CHEBI:57923; EC=3.1.3.95; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3- phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:42328, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:65221, ChEBI:CHEBI:78934; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5- bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:45632, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:78911, ChEBI:CHEBI:85342; Evidence=; Interaction with SBF1/MTMR5 increases phosphatase activity (By similarity). Increases SBF2/MTMR13 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (PubMed:16399794). Homodimer (via coiled-coil domain) (PubMed:14530412, PubMed:16399794). Heterotetramer consisting of one MTMR2 dimer and one SBF2/MTMR13 dimer (PubMed:16399794). Heterodimer with SBF1/MTMR5 (By similarity). Heterodimer with MTMR12 (By similarity). Cytoplasm rly endosome membrane ; Peripheral membrane protein Cytoplasm, perinuclear region Cell projection, axon Endosome membrane ; Peripheral membrane protein Note=Partly associated with membranes (PubMed:14530412, PubMed:23297362). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). Expressed in sciatic nerve and in Schwann cells (at protein level) (PubMed:16399794, PubMed:23297362). Detected in adult dorsal root ganglia, neurons of the central nervous system, motor neurons, cell soma and neurites of sensory neurons, olfactory bulb, cerebellum and hippocampus (PubMed:12045210). In 16.5 dpc embryos, expressed in forebrain, dorsal root ganglia, trigeminal ganglia, kidney, adrenal gland and lung. The coiled-coil domain mediates homodimerization (PubMed:14530412). Also mediates interaction with SBF1/MTMR5 and SBF2/MTMR13 (By similarity). The GRAM domain mediates binding to phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5- biphosphate and phosphatidylinositol 3,4,5-trisphosphate. Phosphorylation at Ser-58 decreases MTMR2 localization to endocytic vesicular structures. SBF2/MTMR13 protein levels are decreased in sciatic nerves but not in the brain or in fibroblasts. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. Sequence=AAC80002.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of receptor internalization phosphatidylinositol-3-phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm endosome vacuolar membrane cytosol lipid metabolic process synaptic vesicle endosome membrane postsynaptic density membrane dephosphorylation hydrolase activity phosphatase activity axon dendrite negative regulation of myelination early endosome membrane myelin assembly peptidyl-tyrosine dephosphorylation identical protein binding cell projection dendritic spine intracellular membrane-bounded organelle negative regulation of endocytosis phosphatidylinositol metabolic process inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation perinuclear region of cytoplasm neuron development phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity phosphatidylinositol phosphate phosphatase activity regulation of phosphatidylinositol dephosphorylation negative regulation of excitatory postsynaptic potential synaptic membrane dendritic spine maintenance positive regulation of early endosome to late endosome transport negative regulation of receptor catabolic process uc012god.1 uc012god.2 uc012god.3 
ENSMUST00000034400.5 Cyb5b ENSMUST00000034400.5 cytochrome b5 type B (from RefSeq NM_025558.5) CYB5B_MOUSE Cyb5m ENSMUST00000034400.1 ENSMUST00000034400.2 ENSMUST00000034400.3 ENSMUST00000034400.4 NM_025558 Q9CQX2 Q9D1M6 Q9D8R3 uc009nhg.1 uc009nhg.2 uc009nhg.3 Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. Component of a complex composed of cytochrome b5, NADH- cytochrome b5 reductase (CYB5R3) and MTARC2. Mitochondrion outer membrane Belongs to the cytochrome b5 family. mitochondrion mitochondrial outer membrane mitochondrial inner membrane enzyme activator activity membrane integral component of membrane heme binding positive regulation of catalytic activity intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc009nhg.1 uc009nhg.2 uc009nhg.3 
ENSMUST00000034405.11 Mre11a ENSMUST00000034405.11 MRE11A homolog A, double strand break repair nuclease, transcript variant 15 (from RefSeq NR_177975.1) ENSMUST00000034405.1 ENSMUST00000034405.10 ENSMUST00000034405.2 ENSMUST00000034405.3 ENSMUST00000034405.4 ENSMUST00000034405.5 ENSMUST00000034405.6 ENSMUST00000034405.7 ENSMUST00000034405.8 ENSMUST00000034405.9 MRE11_MOUSE Mre11 NR_177975 Q61216 Q62430 uc009ofc.1 uc009ofc.2 uc009ofc.3 uc009ofc.4 uc009ofc.5 Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Interaction with SAMHD1 stimulates the double- strand-specific 3'-5' exonuclease activity. Component of the MRN complex composed of two heterodimers RAD50/MRE11 associated with a single NBN (By similarity). As part of the MRN complex, interacts with MCM9; the interaction recruits the complex to DNA repair sites (By similarity). Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11 and NBN (By similarity). Found in a complex with TERF2 (By similarity). Interacts with DCLRE1C/Artemis and DCLRE1B/Apollo (By similarity). Interacts with ATF2 (By similarity). Interacts with EXD2 (By similarity). Interacts with MRNIP (By similarity). Interacts with SAMHD1; leading to stimulate 3'-5' exonuclease activity (By similarity). Interacts (when ubiquitinated) with UBQLN4 (via its UBA domain) (By similarity). Interacts with CYREN (via XLF motif) (PubMed:30017584). Q61216; Q9R207: Nbn; NbExp=2; IntAct=EBI-2014813, EBI-2014862; Nucleus Chromosome, telomere Chromosome Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A; IsoId=Q61216-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q61216-2; Sequence=VSP_003263; Ubiquitinated following DNA damage. Ubiquitination triggers interaction with UBQLN4, leading to MRE11 removal from chromatin and degradation by the proteasome. Belongs to the MRE11/RAD32 family. single-stranded DNA endodeoxyribonuclease activity telomere maintenance double-strand break repair via homologous recombination chromosome, telomeric region nuclear chromosome, telomeric region nuclear chromatin condensed nuclear chromosome DNA binding DNA helicase activity nuclease activity endonuclease activity endodeoxyribonuclease activity exonuclease activity protein binding nucleus nucleoplasm replication fork chromosome cytoplasm DNA repair double-strand break repair double-strand break repair via nonhomologous end joining cellular response to DNA damage stimulus sister chromatid cohesion mitotic G2 DNA damage checkpoint synapsis protein C-terminus binding cell proliferation 3'-5' exonuclease activity 5'-3' exonuclease activity PML body hydrolase activity manganese ion binding Mre11 complex intra-S DNA damage checkpoint telomeric 3' overhang formation positive regulation of protein autophosphorylation positive regulation of telomere maintenance DNA duplex unwinding negative regulation of DNA endoreduplication positive regulation of kinase activity site of double-strand break meiotic DNA double-strand break formation identical protein binding negative regulation of apoptotic process negative regulation of viral entry into host cell perinuclear region of cytoplasm chromosome organization meiotic cell cycle mitochondrial double-strand break repair via homologous recombination uc009ofc.1 uc009ofc.2 uc009ofc.3 uc009ofc.4 uc009ofc.5 
ENSMUST00000034408.12 Gpr83 ENSMUST00000034408.12 G protein-coupled receptor 83, transcript variant 1 (from RefSeq NM_010287.3) ENSMUST00000034408.1 ENSMUST00000034408.10 ENSMUST00000034408.11 ENSMUST00000034408.2 ENSMUST00000034408.3 ENSMUST00000034408.4 ENSMUST00000034408.5 ENSMUST00000034408.6 ENSMUST00000034408.7 ENSMUST00000034408.8 ENSMUST00000034408.9 GPR83_MOUSE Gir Gpr72 Gpr83 Jp05 NM_010287 P30731 Q542Q9 Q544C4 uc009off.1 uc009off.2 uc009off.3 G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN (PubMed:27117253). Plays a role in food intake and body weight regulation (PubMed:23744028). May contribute to the regulation of anxiety-related behaviors (PubMed:34512237). Cell membrane ; Multi-pass membrane protein Note=Colocalizes with GPR171 in the paraventricular nucleus (PubMed:27117253). Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus (PubMed:23744028). Event=Alternative splicing; Named isoforms=4; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=P30731-1; Sequence=Displayed; Name=2; Synonyms=RP39; IsoId=P30731-2; Sequence=VSP_001988; Name=3; Synonyms=RP82; IsoId=P30731-3; Sequence=VSP_001989; Name=4; Synonyms=RP105; IsoId=P30731-4; Sequence=VSP_001990; Predominantly expressed in the brain, with moderate expression in the hypothalamus (PubMed:23744028). Expressed in the thymus (PubMed:16141072). By glucocorticoids and cAMP in T-cells. Deficient mice have normal body weight and glucose tolerance when fed a regular chow diet, but are protected from obesity and glucose intolerance when challenged with a high-fat diet (PubMed:23744028). Knockdown of GPR83 has minimal impact on anxiety- like behaviors in female mice and a decrease in anxiety-related behaviors in male mice. In contrast, a local GPR83 knockdown in the basolateral amygdala leads to more anxiety-related behaviors in female mice (PubMed:34512237). Belongs to the G-protein coupled receptor 1 family. NPY has been reported to be a ligand for GPR83 (By similarity). However, a more recent study found that radiolabeled PEN binding to GPR83 is not affected by NPY concentrations below 1 mM, only very high, non-physiological concentrations causes a partial, displacement of PEN binding (PubMed:27117253). G-protein coupled receptor activity neuropeptide Y receptor activity plasma membrane cilium signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway membrane integral component of membrane response to glucocorticoid non-motile cilium uc009off.1 uc009off.2 uc009off.3 
ENSMUST00000034409.14 Izumo1r ENSMUST00000034409.14 IZUMO1 receptor, JUNO, transcript variant 1 (from RefSeq NM_022888.3) B0FFS5 ENSMUST00000034409.1 ENSMUST00000034409.10 ENSMUST00000034409.11 ENSMUST00000034409.12 ENSMUST00000034409.13 ENSMUST00000034409.2 ENSMUST00000034409.3 ENSMUST00000034409.4 ENSMUST00000034409.5 ENSMUST00000034409.6 ENSMUST00000034409.7 ENSMUST00000034409.8 ENSMUST00000034409.9 Folbp3 Folr4 Izumo1r JUNO_MOUSE Juno NM_022888 Q9EQF4 uc009ofh.1 uc009ofh.2 uc009ofh.3 uc009ofh.4 Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization (PubMed:24739963, PubMed:26859261, PubMed:27309808, PubMed:27416963). The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:24739963, PubMed:26859261, PubMed:27309808). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed:24739963, PubMed:26859261, PubMed:27309808). Does not bind folate (PubMed:24739963). Monomer (PubMed:26859261). Interacts with IZUMO1; the interaction is direct (PubMed:24739963, PubMed:26859261, PubMed:27309808, PubMed:25209248, PubMed:27416963, PubMed:32484434). IZUMO1 and IZUMO1R/JUNO form a complex with 1:1 stoichiometry (By similarity). Cell membrane ipid- anchor, GPI-anchor Note=GPI-anchored at the oolemma. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EQF4-1; Sequence=Displayed; Name=2; Synonyms=FR4v3; IsoId=Q9EQF4-2; Sequence=VSP_033414; Widely expressed with higher expression in thymus, spleen and lung (PubMed:11111049). Present at the cell surface of unfertilized oocytes, while it is barely detectable 30 to 40 minutes after fertilization (at protein level) (PubMed:24739963). The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage (PubMed:24739963). Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm (PubMed:24739963). Female mice are infertile and eggs do not fuse with normal sperm (PubMed:24739963). Both male and female mice develop normally and are overtly healthy (PubMed:24739963). Male mice are fertile (PubMed:24739963). Despite infertility, female mice display natural mating behaviors, as assessed by vaginal plug formation and the presence of motile sperm in the reproductive tract when paired with fertile males (PubMed:24739963). They respond to hormone treatment by ovulating morphologically normal eggs at numbers that do not significantly differ from wild-type (PubMed:24739963). However, eggs are not fertilized and have more sperm within their perivitelline space compared to wild-type eggs, demonstrating that the zona pellucida of eggs cannot be penetrated by sperm in vivo (PubMed:24739963). Was named 'Juno' after the Roman goddess of fertility and marriage. Belongs to the folate receptor family. In contrast to FOLR1 and FOLR2, unable to bind folate. receptor binding protein binding plasma membrane cell adhesion single fertilization fusion of sperm to egg plasma membrane membrane anchored component of membrane anchored component of external side of plasma membrane sperm-egg recognition signaling receptor activity folic acid binding uc009ofh.1 uc009ofh.2 uc009ofh.3 uc009ofh.4 
ENSMUST00000034411.10 Med17 ENSMUST00000034411.10 mediator complex subunit 17, transcript variant 1 (from RefSeq NM_144933.2) Crsp6 ENSMUST00000034411.1 ENSMUST00000034411.2 ENSMUST00000034411.3 ENSMUST00000034411.4 ENSMUST00000034411.5 ENSMUST00000034411.6 ENSMUST00000034411.7 ENSMUST00000034411.8 ENSMUST00000034411.9 MED17_MOUSE NM_144933 Q8BYS6 Q8VCD5 Q99KQ1 Trap80 uc009ofl.1 uc009ofl.2 uc009ofl.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with STAT2 (By similarity). Interacts with GATA1 and PPARG. Q8VCD5; Q04207: Rela; NbExp=4; IntAct=EBI-5744951, EBI-644400; Nucleus Belongs to the Mediator complex subunit 17 family. ubiquitin ligase complex transcription cofactor activity transcription coactivator activity protein binding nucleus nucleoplasm transcription factor complex regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter protein ubiquitination mediator complex stem cell population maintenance ligand-dependent nuclear receptor transcription coactivator activity positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter thyroid hormone receptor binding ubiquitin protein ligase activity core mediator complex uc009ofl.1 uc009ofl.2 uc009ofl.3 
ENSMUST00000034413.8 Vstm5 ENSMUST00000034413.8 V-set and transmembrane domain containing 5 (from RefSeq NM_026955.2) ENSMUST00000034413.1 ENSMUST00000034413.2 ENSMUST00000034413.3 ENSMUST00000034413.4 ENSMUST00000034413.5 ENSMUST00000034413.6 ENSMUST00000034413.7 NM_026955 Q9D806 VSTM5_MOUSE Vstm5 uc009ofk.1 uc009ofk.2 uc009ofk.3 Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain. Can homooligomerize through cis interactions within the same cell membrane. Cell membrane ; Single-pass type I membrane protein Cell projection, dendrite Cell projection, axon Highly expressed in the central nervous system (CNS), with the highest expression in thalamus, hippocampus, cerebrum, midbrain and spinal cord. Also highly expressed in stomach, kidney and small intestine. Expressed in the ventral spinal cord, with strong expression in a subset of motor neurons, and in a subset of sensory neurons at embryonic day (E) 15.5 (PubMed:25826454). In the developing brain, expressed at low levels on 11 dpc, rapidly increasing to peak at postnatal day (P) 1, a period corresponding to the early stage of postmitotic neuronal differentiation when neuronal morphogenesis or synapse formation occurs, and then gradually decreasing (PubMed:27683913). N-glycosylated. RNAi-mediated knockdown mice have significantly lower density of dendritic filopodia and dendritic spines in embryonic hippocampal neurons. Lower density of excitatory synapses and significantly decreased dendritic spine to shaft ratio of F-actin in the later stages of neuron development. Aberrant neuronal migration in the cerebral cortex of developing mouse embryo. Neurons settle in the marginal zone (MZ) closer to the pial side and the corresponding percentage of neurons is decreased in the dense cortical plate (dCP), reflecting the overmigration of those neurons. Neurons in the upper cortical plate (UCP) result in a small but significant reduction in both the number of dendrites and average dendrite length. Neurons of embryonic brains show much lower levels of spines with the density of mushroom spines markedly decreased. molecular_function plasma membrane multicellular organism development membrane integral component of membrane ventral spinal cord development axon dendrite cell projection filopodium assembly protein homooligomerization positive regulation of excitatory synapse assembly uc009ofk.1 uc009ofk.2 uc009ofk.3 
ENSMUST00000034415.6 Taf1d ENSMUST00000034415.6 TATA-box binding protein associated factor, RNA polymerase I, D, transcript variant 2 (from RefSeq NM_029248.2) ENSMUST00000034415.1 ENSMUST00000034415.2 ENSMUST00000034415.3 ENSMUST00000034415.4 ENSMUST00000034415.5 Josd3 NM_029248 Q149X7 Q8C7I5 Q9CZG0 Q9D4V4 Q9D5U6 TAF1D_MOUSE uc009ofp.1 uc009ofp.2 uc009ofp.3 Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D4V4-1; Sequence=Displayed; Name=2; IsoId=Q9D4V4-2; Sequence=VSP_020729; Name=3; IsoId=Q9D4V4-3; Sequence=VSP_020730; molecular_function DNA binding nucleus nucleoplasm RNA polymerase transcription factor SL1 complex microtubule organizing center regulation of transcription, DNA-templated biological_process uc009ofp.1 uc009ofp.2 uc009ofp.3 
ENSMUST00000034426.14 Kars1 ENSMUST00000034426.14 lysyl-tRNA synthetase 1, transcript variant 2 (from RefSeq NM_053092.3) ENSMUST00000034426.1 ENSMUST00000034426.10 ENSMUST00000034426.11 ENSMUST00000034426.12 ENSMUST00000034426.13 ENSMUST00000034426.2 ENSMUST00000034426.3 ENSMUST00000034426.4 ENSMUST00000034426.5 ENSMUST00000034426.6 ENSMUST00000034426.7 ENSMUST00000034426.8 ENSMUST00000034426.9 Kars Kars1 NM_053092 Q99MN1 SYK_MOUSE uc009nne.1 uc009nne.2 uc009nne.3 uc009nne.4 uc009nne.5 Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. Reaction=ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl- tRNA(Lys); Xref=Rhea:RHEA:20792, Rhea:RHEA-COMP:9696, Rhea:RHEA- COMP:9697, ChEBI:CHEBI:30616, ChEBI:CHEBI:32551, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78529, ChEBI:CHEBI:456215; EC=6.1.1.6; Evidence=; Homodimer (By similarity). Part of the multisynthetase complex (MSC), a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:14975237). Interacts with AIMP2 (via N-terminus) and MITF (PubMed:14975237). Interacts with TARSL2 (By similarity). Cytoplasm, cytosol Cytoplasm Nucleus Cell membrane ; Peripheral membrane protein Secreted Note=Secretion is induced by TNF-alpha. Cytosolic in quiescent mast cells. Translocates into the nucleus in response to mast cell activation by immunoglobulin E. The N-terminal domain (1-65) is a functional tRNA-binding domain and is involved in the interaction with DARS, but has a repulsive role in the binding to EEF1A1. A central domain (208-259) is involved in homodimerization. The C-terminal domain (452-597) is not required for interaction with AIMP2 (By similarity). Phosphorylated on a serine residue after mast cell stimulation with immunoglobulin E (IgE). It is likely that the same gene provides both this cytoplasmic isoform and an additional mitochondrial isoform. Shares a bidirectional promoter with Terf2ip/Rap1. Belongs to the class-II aminoacyl-tRNA synthetase family. tRNA binding nucleotide binding activation of MAPK activity basophil activation involved in immune response positive regulation of cytokine secretion involved in immune response nucleic acid binding ATP adenylyltransferase activity aminoacyl-tRNA ligase activity lysine-tRNA ligase activity ATP binding extracellular region extracellular space nucleus cytoplasm mitochondrion cytosol plasma membrane translation tRNA aminoacylation for protein translation lysyl-tRNA aminoacylation negative regulation of cell proliferation response to X-ray positive regulation of macrophage chemotaxis diadenosine tetraphosphate biosynthetic process membrane amino acid binding transferase activity ligase activity aminoacyl-tRNA synthetase multienzyme complex tumor necrosis factor-mediated signaling pathway identical protein binding protein homodimerization activity positive regulation of macrophage activation positive regulation of transcription, DNA-templated ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade scaffold protein binding positive regulation of cytokine production involved in inflammatory response positive regulation of p38MAPK cascade positive regulation of metallopeptidase activity uc009nne.1 uc009nne.2 uc009nne.3 uc009nne.4 uc009nne.5 
ENSMUST00000034427.12 Adat1 ENSMUST00000034427.12 adenosine deaminase, tRNA-specific 1, transcript variant 1 (from RefSeq NM_013925.5) ADAT1_MOUSE ENSMUST00000034427.1 ENSMUST00000034427.10 ENSMUST00000034427.11 ENSMUST00000034427.2 ENSMUST00000034427.3 ENSMUST00000034427.4 ENSMUST00000034427.5 ENSMUST00000034427.6 ENSMUST00000034427.7 ENSMUST00000034427.8 ENSMUST00000034427.9 NM_013925 Q3TU04 Q8CBP0 Q8VE23 Q9JHI2 uc009nnc.1 uc009nnc.2 Specifically deaminates adenosine-37 to inosine in tRNA-Ala. Reaction=adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+); Xref=Rhea:RHEA:50968, Rhea:RHEA-COMP:12855, Rhea:RHEA-COMP:12856, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.34; Evidence=; Name=1D-myo-inositol hexakisphosphate; Xref=ChEBI:CHEBI:58130; Evidence=; Note=Binds 1 myo-inositol hexakisphosphate (IP6) per subunit. ; Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9JHI2-1; Sequence=Displayed; Name=2; IsoId=Q9JHI2-2; Sequence=VSP_025581; Name=3; IsoId=Q9JHI2-3; Sequence=VSP_025580, VSP_025581; Belongs to the ADAT1 family. RNA binding adenosine deaminase activity cellular_component RNA processing tRNA processing tRNA-specific adenosine deaminase activity hydrolase activity metal ion binding uc009nnc.1 uc009nnc.2 
ENSMUST00000034428.8 Gabarapl2 ENSMUST00000034428.8 GABA type A receptor associated protein like 2 (from RefSeq NM_026693.5) ENSMUST00000034428.1 ENSMUST00000034428.2 ENSMUST00000034428.3 ENSMUST00000034428.4 ENSMUST00000034428.5 ENSMUST00000034428.6 ENSMUST00000034428.7 GBRL2_MOUSE Gabarapl2 NM_026693 O08765 P60521 Q9DCP8 Q9UQF7 uc009nnb.1 uc009nnb.2 uc009nnb.3 uc009nnb.4 Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). Monomer (By similarity). Interacts with ATG3, ATG13 and ULK1 (By similarity). Interacts with ATG7 (PubMed:11890701). Interacts with TP53INP1 and TP53INP2 (By similarity). Interacts with TBC1D25 (PubMed:21383079). Directly interacts with SQSTM1 and BNIP3 (By similarity). Interacts with TECPR2 and PCM1 (By similarity). Interacts with TBC1D5 (By similarity). Interacts with TRIM5 (By similarity). Interacts with MEFV and TRIM21 (By similarity). Interacts with WDFY3 (By similarity). Interacts with UBA5; promoting recruitment of UBA5 to the endoplasmic reticulum membrane (By similarity). Interacts with GOSR1 (By similarity). Interacts with KBTBD6 and KBTBD7; the interaction is direct (By similarity). Interacts with reticulophagy regulators RETREG1, RETREG2 and RETREG3 (PubMed:34338405). Interacts with Irgm1 (By similarity). Interacts with DNM2 (By similarity). Cytoplasmic vesicle, autophagosome Endoplasmic reticulum membrane Golgi apparatus Ubiquitous. A high level expression is seen in brain, thymus, lung, heart, liver and kidney. The precursor molecule is cleaved by ATG4 (ATG4A, ATG4B, ATG4C or ATG4D) to expose the glycine at the C-terminus and form the cytosolic form, GABARAPL2-I (PubMed:14530254). The processed form is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, GABARAPL2-II (By similarity). During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid (By similarity). ATG4 proteins also mediate the delipidation of PE- conjugated forms required for GABARAPL2 recycling when autophagosomes fuse with lysosomes (PubMed:33795848). In addition, ATG4B and ATG4D mediate delipidation of ATG8 proteins conjugated to PS during non- canonical autophagy (By similarity). ATG4B constitutes the major protein for proteolytic activation (By similarity). ATG4D is the main enzyme for delipidation activity (PubMed:33795848). Phosphorylation at Ser-87 and Ser-88 by TBK1 prevents interaction with ATG4 (ATG4A, ATG4B, ATG4C or ATG4D). Phosphorylation by TBK1 on autophagosomes prevents their delipidation by ATG4 and premature removal from nascent autophagosomes. Belongs to the ATG8 family. autophagosome assembly Golgi membrane autophagosome membrane mitophagy protein binding cytoplasm autophagosome Golgi apparatus cytosol intra-Golgi vesicle-mediated transport autophagy cellular response to nitrogen starvation microtubule binding protein transport macroautophagy cytoplasmic vesicle ubiquitin protein ligase binding autophagosome maturation negative regulation of proteasomal protein catabolic process uc009nnb.1 uc009nnb.2 uc009nnb.3 uc009nnb.4 
ENSMUST00000034429.9 Tmem231 ENSMUST00000034429.9 transmembrane protein 231, transcript variant 2 (from RefSeq NM_001357348.1) ENSMUST00000034429.1 ENSMUST00000034429.2 ENSMUST00000034429.3 ENSMUST00000034429.4 ENSMUST00000034429.5 ENSMUST00000034429.6 ENSMUST00000034429.7 ENSMUST00000034429.8 NM_001357348 Q3U284 Q497S7 TM231_MOUSE uc009nna.1 uc009nna.2 uc009nna.3 Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling. Part of the tectonic-like complex (also named B9 complex) (PubMed:22179047). Interacts with TMEM107 (By similarity). Cell projection, cilium membrane ; Multi-pass membrane protein Note=Localizes to the transition zone of primary cilia; SEPT2 is required for localization to the transition zone. Embryos die around 15.5 dpc with severe vascular defects. 10.5 dpc mutant embryos have defects in patterning of the ventral spinal cord that are characteristic of defects in Shh signaling. 14.5 dpc embryos exhibit microphthalmia and polydactyly, consistent with disruptions in Shh signaling. Belongs to the TMEM231 family. in utero embryonic development vasculature development protein binding plasma membrane cilium smoothened signaling pathway membrane integral component of membrane cell projection organization regulation of protein localization ciliary transition zone MKS complex embryonic digit morphogenesis cell projection camera-type eye development ciliary membrane cilium assembly neuroepithelial cell differentiation uc009nna.1 uc009nna.2 uc009nna.3 
ENSMUST00000034430.6 Chst5 ENSMUST00000034430.6 carbohydrate sulfotransferase 5 (from RefSeq NM_019950.2) CHST5_MOUSE ENSMUST00000034430.1 ENSMUST00000034430.2 ENSMUST00000034430.3 ENSMUST00000034430.4 ENSMUST00000034430.5 Gst4 NM_019950 Q9QUP4 uc009nmz.1 uc009nmz.2 uc009nmz.3 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non- reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures. May also have activity toward O-linked sugars of mucin-type acceptors. Golgi apparatus membrane ; Single- pass type II membrane protein Note=Golgi membrane, early secretory pathway. Expressed in cornea. In human, there are 2 related proteins, CHST5 and CHST6, the latter mediating sulfation of keratan in cornea. In mouse however, there is no CHST6 protein, CHST5 functioning as a corneal keratan sulfotransferase and mediates such function. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. Golgi membrane N-acetylglucosamine 6-O-sulfotransferase activity Golgi apparatus trans-Golgi network carbohydrate metabolic process N-acetylglucosamine metabolic process sulfur compound metabolic process sulfotransferase activity membrane integral component of membrane transferase activity keratan sulfate biosynthetic process uc009nmz.1 uc009nmz.2 uc009nmz.3 
ENSMUST00000034431.3 Tmem170 ENSMUST00000034431.3 transmembrane protein 170 (from RefSeq NM_025781.2) A6H6Q8 D8Bwg1414e ENSMUST00000034431.1 ENSMUST00000034431.2 NM_025781 Q9D342 T170A_MOUSE Tmem170a uc009nmy.1 uc009nmy.2 uc009nmy.3 Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. Interacts with RTN4. Endoplasmic reticulum membrane ; Multi-pass membrane protein Nucleus envelope Belongs to the TMEM170 family. molecular_function nucleus nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane nuclear envelope organization membrane integral component of membrane nuclear pore complex assembly endoplasmic reticulum tubular network organization uc009nmy.1 uc009nmy.2 uc009nmy.3 
ENSMUST00000034432.7 Cfdp1 ENSMUST00000034432.7 craniofacial development protein 1, transcript variant 1 (from RefSeq NM_011801.2) Bcnt CFDP1_MOUSE Cfdp Cp27 ENSMUST00000034432.1 ENSMUST00000034432.2 ENSMUST00000034432.3 ENSMUST00000034432.4 ENSMUST00000034432.5 ENSMUST00000034432.6 NM_011801 O70565 O88271 Q9JMA5 uc009nmx.1 uc009nmx.2 uc009nmx.3 May play a role during embryogenesis. May modulate tooth organogenesis since alterations of this protein function affect tooth organs size as well as individual cell fate and survival. In embryonic cells, blockage of the function results in increased number of apoptotic cells, reduced proliferation, alterations in cell shape and fibronection matrix synthesis. Chromosome, centromere, kinetochore Expressed in lung, liver and heart, with higher expression in teeth. Detected at 8 dpc in developing organs, including brain, heart, lung and intestines. Expressed at 14 dpc and 16 dpc at the periphery of developing organs such as bones and teeth. chromosome, centromeric region kinetochore condensed chromosome kinetochore basement membrane chromosome cell adhesion multicellular organism development regulation of cell shape regulation of cell proliferation negative regulation of fibroblast apoptotic process uc009nmx.1 uc009nmx.2 uc009nmx.3 
ENSMUST00000034435.7 Ctrb1 ENSMUST00000034435.7 chymotrypsinogen B1 (from RefSeq NM_025583.2) CTRB1_MOUSE ENSMUST00000034435.1 ENSMUST00000034435.2 ENSMUST00000034435.3 ENSMUST00000034435.4 ENSMUST00000034435.5 ENSMUST00000034435.6 NM_025583 Q9CR35 Q9D8X8 Q9DC86 uc009nms.1 uc009nms.2 uc009nms.3 uc009nms.4 Reaction=Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|- Xaa.; EC=3.4.21.1; Evidence= Secreted, extracellular space Belongs to the peptidase S1 family. serine-type endopeptidase activity extracellular region extracellular space cytoplasm lysosome proteolysis digestion peptidase activity serine-type peptidase activity hydrolase activity protein catabolic process response to cytokine positive regulation of apoptotic process uc009nms.1 uc009nms.2 uc009nms.3 uc009nms.4 
ENSMUST00000034441.8 Aars1 ENSMUST00000034441.8 alanyl-tRNA synthetase 1 (from RefSeq NM_146217.4) Aars Aars1 ENSMUST00000034441.1 ENSMUST00000034441.2 ENSMUST00000034441.3 ENSMUST00000034441.4 ENSMUST00000034441.5 ENSMUST00000034441.6 ENSMUST00000034441.7 NM_146217 Q8BGQ7 Q8BXR0 SYAC_MOUSE uc009nlo.1 uc009nlo.2 uc009nlo.3 uc009nlo.4 Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:16906134, PubMed:20010690, PubMed:25422440, PubMed:27622773). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:16906134, PubMed:20010690, PubMed:25422440, PubMed:29769718). Reaction=ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl- tRNA(Ala); Xref=Rhea:RHEA:12540, Rhea:RHEA-COMP:9657, Rhea:RHEA- COMP:9923, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57972, ChEBI:CHEBI:78442, ChEBI:CHEBI:78497, ChEBI:CHEBI:456215; EC=6.1.1.7; Evidence= Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Monomer (By similarity). Interacts with ANKRD16; the interaction is direct (PubMed:29769718). Q8BGQ7; A2AS55-1: Ankrd16; NbExp=6; IntAct=EBI-11566807, EBI-20710644; Cytoplasm Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs. ISGylated. Methylation at 'Lys-943' by METTL21C. Note=In sticky (sti); homozygous mice display an unkempt sticky appearance of fur and show cerebellar Purkinje cell loss and ataxia. Defects are caused by impaired ability to edit incorrectly charged tRNA(Ala), resulting in a two-fold increase in Ser-mischarged tRNA(Ala). This results in formation of ubiquitinated protein aggregates in cerebellar Purkinje cells and degeneration of these neurons. Was named 'sticky' because of the sticky characteristics of the fur in mice homozygous for the Glu-734 variant. Belongs to the class-II aminoacyl-tRNA synthetase family. tRNA binding nucleotide binding aminoacyl-tRNA editing activity Ser-tRNA(Ala) hydrolase activity nucleic acid binding RNA binding aminoacyl-tRNA ligase activity alanine-tRNA ligase activity protein binding ATP binding cytoplasm mitochondrion cytosol tRNA modification translation alanyl-tRNA aminoacylation zinc ion binding amino acid binding ligase activity cerebellar Purkinje cell layer development tRNA aminoacylation negative regulation of neuron apoptotic process translation regulator activity metal ion binding neuromuscular process controlling balance neuromuscular process mitochondrial alanyl-tRNA aminoacylation uc009nlo.1 uc009nlo.2 uc009nlo.3 uc009nlo.4 
ENSMUST00000034443.7 Cdh15 ENSMUST00000034443.7 cadherin 15 (from RefSeq NM_007662.2) B2RXU1 CAD15_MOUSE Cdh14 ENSMUST00000034443.1 ENSMUST00000034443.2 ENSMUST00000034443.3 ENSMUST00000034443.4 ENSMUST00000034443.5 ENSMUST00000034443.6 NM_007662 P33146 Q9QYZ7 uc009ntv.1 uc009ntv.2 uc009ntv.3 This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Based on the expression of this gene in skeletal muscle, satellite cells and cerebellum, it was postulated that the encoded protein may be important for muscle development and regeneration. Mice lacking the encoded protein appear normal and display no discernible defects in skeletal musculature. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M74541.1, BC157978.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. Cell membrane; Single-pass type I membrane protein. Skeletal muscle. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. cell morphogenesis calcium ion binding protein binding Golgi apparatus cytosol plasma membrane caveola cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cytoskeletal protein binding cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex neuromuscular junction adherens junction organization protein homodimerization activity cell-cell adhesion mediated by cadherin cadherin binding metal ion binding cell-cell adhesion uc009ntv.1 uc009ntv.2 uc009ntv.3 
ENSMUST00000034453.6 Acta1 ENSMUST00000034453.6 actin alpha 1, skeletal muscle, transcript variant 2 (from RefSeq NM_009606.3) ACTS_MOUSE Acta ENSMUST00000034453.1 ENSMUST00000034453.2 ENSMUST00000034453.3 ENSMUST00000034453.4 ENSMUST00000034453.5 NM_009606 P02568 P68134 P99020 uc009nwr.1 uc009nwr.2 uc009nwr.3 uc009nwr.4 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with alpha- actinin. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity). Interacts with TTID. Interacts (via its C- terminus) with USP25 (By similarity). Cytoplasm, cytoskeleton. Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization. Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. Methylated at His-75 by SETD3. [Actin, alpha skeletal muscle, intermediate form]: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP. In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Belongs to the actin family. nucleotide binding stress fiber protein binding ATP binding cytoplasm cytoskeleton striated muscle thin filament actin filament response to mechanical stimulus response to extracellular stimulus response to lithium ion positive regulation of gene expression actin cytoskeleton sarcomere lamellipodium filopodium skeletal muscle thin filament assembly macromolecular complex skeletal muscle fiber adaptation cell body response to steroid hormone skeletal muscle fiber development cellular response to organonitrogen compound mesenchyme migration uc009nwr.1 uc009nwr.2 uc009nwr.3 uc009nwr.4 
ENSMUST00000034457.9 Urb2 ENSMUST00000034457.9 URB2 ribosome biogenesis 2 homolog (S. cerevisiae), transcript variant 2 (from RefSeq NM_001368414.1) E9Q7L1 E9Q7L1_MOUSE ENSMUST00000034457.1 ENSMUST00000034457.2 ENSMUST00000034457.3 ENSMUST00000034457.4 ENSMUST00000034457.5 ENSMUST00000034457.6 ENSMUST00000034457.7 ENSMUST00000034457.8 NM_001368414 Urb2 uc012gmv.1 uc012gmv.2 uc012gmv.3 molecular_function nucleolus aggresome midbody ribosome biogenesis uc012gmv.1 uc012gmv.2 uc012gmv.3 
ENSMUST00000034458.9 Galnt2 ENSMUST00000034458.9 polypeptide N-acetylgalactosaminyltransferase 2 (from RefSeq NM_139272.2) ENSMUST00000034458.1 ENSMUST00000034458.2 ENSMUST00000034458.3 ENSMUST00000034458.4 ENSMUST00000034458.5 ENSMUST00000034458.6 ENSMUST00000034458.7 ENSMUST00000034458.8 GALT2_MOUSE NM_139272 Q6PB93 Q7TSI5 Q8BL27 Q922K5 Q99ME1 uc009nwz.1 uc009nwz.2 uc009nwz.3 uc009nwz.4 uc009nwz.5 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region (By similarity). Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism (PubMed:27508872). Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Secreted Note=Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PB93-1; Sequence=Displayed; Name=2; IsoId=Q6PB93-2; Sequence=VSP_011201; Widely expressed at high level. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. GALNT2 knockout results in significant embryonic lethality. Surviving mice show decreased body weight, abnormal craniofacial features, and neuro-behavioral abnormalities, including deficits in coordination and impaired responses to acoustic stimuli (PubMed:32293671). Knockout mice have reduced HDL-C levels compared to wild-type littermate (PubMed:27508872). Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Name=Functional Glycomics Gateway - GTase; Note=Polypeptide N-acetylgalactosaminyltransferase 2; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_511"; immunoglobulin biosynthetic process polypeptide N-acetylgalactosaminyltransferase activity extracellular region extracellular space Golgi apparatus Golgi stack Golgi lumen protein glycosylation protein O-linked glycosylation membrane integral component of membrane O-glycan processing transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via serine protein O-linked glycosylation via threonine manganese ion binding carbohydrate binding Golgi cisterna membrane metal ion binding perinuclear region of cytoplasm uc009nwz.1 uc009nwz.2 uc009nwz.3 uc009nwz.4 uc009nwz.5 
ENSMUST00000034460.11 Cog2 ENSMUST00000034460.11 component of oligomeric golgi complex 2 (from RefSeq NM_029746.3) COG2_MOUSE ENSMUST00000034460.1 ENSMUST00000034460.10 ENSMUST00000034460.2 ENSMUST00000034460.3 ENSMUST00000034460.4 ENSMUST00000034460.5 ENSMUST00000034460.6 ENSMUST00000034460.7 ENSMUST00000034460.8 ENSMUST00000034460.9 Ldlc NM_029746 Q3TF44 Q921L5 Q9CSQ1 uc009nxd.1 uc009nxd.2 uc009nxd.3 uc009nxd.4 Required for normal Golgi morphology and function. Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the COG2 family. Golgi membrane Golgi apparatus Golgi stack cytosol intra-Golgi vesicle-mediated transport Golgi organization protein transport membrane Golgi transport complex macromolecular complex binding uc009nxd.1 uc009nxd.2 uc009nxd.3 uc009nxd.4 
ENSMUST00000034463.4 Arv1 ENSMUST00000034463.4 ARV1 homolog, fatty acid homeostasis modulator, transcript variant 1 (from RefSeq NM_026855.5) ARV1_MOUSE ENSMUST00000034463.1 ENSMUST00000034463.2 ENSMUST00000034463.3 NM_026855 Q8BY08 Q9D0U9 uc009nxn.1 uc009nxn.2 Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:20663892). Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892). Endoplasmic reticulum membrane ; Multi-pass membrane protein Ubiquitous. Highly expressed in lung. Mice show an increase in the abundance of type 1 oxidative muscle fibers in the diaphragm. Female mice show also an increase in the abundance of type 1 muscle fibers in the extensor digitorum longus. Conditional knockout in neurons leads to decreased body mass; male show reduced white adipose tissue mass while female show reduced perigonadal fat mass. Show also abnormal circling behavior and severe seizures. Belongs to the ARV1 family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus lipid metabolic process sphingolipid metabolic process lipid transport steroid metabolic process cholesterol metabolic process bile acid metabolic process membrane integral component of membrane sterol metabolic process cholesterol transport intracellular sterol transport regulation of intracellular cholesterol transport cortical endoplasmic reticulum regulation of cholesterol metabolic process regulation of plasma membrane sterol distribution uc009nxn.1 uc009nxn.2 
ENSMUST00000034464.8 2310022B05Rik ENSMUST00000034464.8 RIKEN cDNA 2310022B05 gene (from RefSeq NM_175149.4) CA198_MOUSE ENSMUST00000034464.1 ENSMUST00000034464.2 ENSMUST00000034464.3 ENSMUST00000034464.4 ENSMUST00000034464.5 ENSMUST00000034464.6 ENSMUST00000034464.7 NM_175149 Q3TCS2 Q3U2K7 Q3U3E1 Q6PDM3 Q8C3W1 uc009nxg.1 uc009nxg.2 Cytoplasm molecular_function cytoplasm cytosol biological_process uc009nxg.1 uc009nxg.2 
ENSMUST00000034465.9 2810004N23Rik ENSMUST00000034465.9 RIKEN cDNA 2810004N23 gene (from RefSeq NM_025615.2) CA131_MOUSE ENSMUST00000034465.1 ENSMUST00000034465.2 ENSMUST00000034465.3 ENSMUST00000034465.4 ENSMUST00000034465.5 ENSMUST00000034465.6 ENSMUST00000034465.7 ENSMUST00000034465.8 NM_025615 Q3UNZ3 Q8CIL4 Q9CZF4 uc009nxs.1 uc009nxs.2 uc009nxs.3 uc009nxs.4 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Prevents helicase DHX37 to be recruited before post-A1 state. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Chromosome Nucleus, nucleolus chromosome biological_process uc009nxs.1 uc009nxs.2 uc009nxs.3 uc009nxs.4 
ENSMUST00000034466.10 Gnpat ENSMUST00000034466.10 glyceronephosphate O-acyltransferase (from RefSeq NM_010322.3) ENSMUST00000034466.1 ENSMUST00000034466.2 ENSMUST00000034466.3 ENSMUST00000034466.4 ENSMUST00000034466.5 ENSMUST00000034466.6 ENSMUST00000034466.7 ENSMUST00000034466.8 ENSMUST00000034466.9 Gnpat NM_010322 Q545P6 Q545P6_MOUSE uc009nxv.1 uc009nxv.2 uc009nxv.3 Reaction=an acyl-CoA + dihydroxyacetone phosphate = a 1-acylglycerone 3-phosphate + CoA; Xref=Rhea:RHEA:17657, ChEBI:CHEBI:57287, ChEBI:CHEBI:57534, ChEBI:CHEBI:57642, ChEBI:CHEBI:58342; EC=2.3.1.42; Evidence=; Membrane lipid metabolism; glycerophospholipid metabolism. Phospholipid metabolism. Peroxisome membrane ; Peripheral membrane protein ; Matrix side Belongs to the GPAT/DAPAT family. mitochondrion peroxisome peroxisomal membrane glycerophospholipid metabolic process response to nutrient O-acyltransferase activity ether lipid biosynthetic process membrane glycerone-phosphate O-acyltransferase activity palmitoyl-CoA hydrolase activity transferase activity transferase activity, transferring acyl groups response to drug response to starvation cellular lipid metabolic process response to fatty acid uc009nxv.1 uc009nxv.2 uc009nxv.3 
ENSMUST00000034467.7 Sprtn ENSMUST00000034467.7 SprT-like N-terminal domain (from RefSeq NM_001111141.2) B2RY42 ENSMUST00000034467.1 ENSMUST00000034467.2 ENSMUST00000034467.3 ENSMUST00000034467.4 ENSMUST00000034467.5 ENSMUST00000034467.6 G3X912 Gm505 NM_001111141 SPRTN_MOUSE Sprtn uc009nxx.1 uc009nxx.2 uc009nxx.3 uc009nxx.4 DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:28199696, PubMed:27871365). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:28199696, PubMed:27871365). Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis. Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4 (By similarity). Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs. SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity). Involved in recruitment of VCP/p97 to sites of DNA damage. Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation. Does not activate CHEK1 in response to DNA damage. May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; DNA-binding activates the protease activity: single-stranded DNA-binding specifically activates ability to cleave covalent DNA-protein cross-links (DPCs). In contrast, double-stranded DNA-binding specifically activates autocatalytic cleavage, and subsequent inactivation. Homodimer. Interacts (VIA PIP-box) with PCNA (when ubiquitinated). Interacts (via its SHP-box) with VCP/p97. Interacts with RAD18. Interacts with KCTD13 and POLD3. Nucleus Chromosome Note=Localizes to sites of UV damage via the PIP-box. Recruited to stalled replication forks at sites of replication stress following deubiquitination. CHEK1 stimulates recruitment to chromatin. The PIP-box mediates the interaction with PCNA, while the UBZ4- type zinc finger mediates binding to 'Lys-48'- and 'Lys-63'-linked polyubiquitin. Autocatalytically cleaved in response to double-stranded DNA- binding: autocatalytic cleavage takes place in trans and leads to inactivation. Monoubiquitinated; monoubiquitination promotes exclusion from chromatin. Deubiquitinated by VCPIP1: deubiquitination is required for subsequent acetylation and recruitment to chromatin and DNA damage sites. Acetylated following deubiquitination by VCPIP1, leading to recruitment to chromatin and DNA damage sites. Phosphorylation by CHEK1 promotes recruitment to chromatin. Embryonic lethality caused by genomic instability (PubMed:25501849). Cells display impaired lesion bypass, incomplete DNA replication, formation of micronuclei and chromatin bridges and eventually cell death (PubMed:25501849). Cells show an accumulation of DNA-protein cross-links (DPCs) (PubMed:28199696). Sprtn- haploinsufficient mice are viable but show accelerated aging, characterized by cataracts, lordokyphosis and cachexia at a young age (PubMed:25501849). Belongs to the Spartan family. DNA binding nucleus nucleoplasm chromosome DNA repair cellular response to DNA damage stimulus response to UV nuclear speck translesion synthesis positive regulation of protein ubiquitination ubiquitin binding metal ion binding K63-linked polyubiquitin binding uc009nxx.1 uc009nxx.2 uc009nxx.3 uc009nxx.4 
ENSMUST00000034469.7 Egln1 ENSMUST00000034469.7 egl-9 family hypoxia-inducible factor 1, transcript variant 1 (from RefSeq NM_053207.3) EGLN1_MOUSE ENSMUST00000034469.1 ENSMUST00000034469.2 ENSMUST00000034469.3 ENSMUST00000034469.4 ENSMUST00000034469.5 ENSMUST00000034469.6 NM_053207 Q8VHJ2 Q91YE3 Q922P3 uc012gna.1 uc012gna.2 uc012gna.3 Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy- inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif. Reaction=2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia- inducible factor alpha subunit]; Xref=Rhea:RHEA:48400, Rhea:RHEA- COMP:12093, Rhea:RHEA-COMP:12094, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50342, ChEBI:CHEBI:61965; EC=1.14.11.29; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence= Note=Binds 1 Fe(2+) ion per subunit. Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Monomer. Interacts with ING4; the interaction inhibits the hydroxylation of HIF alpha proteins. Interacts with PTGES3 (via PXLE motif); thereby recruiting EGLN1 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation. Interacts with LIMD1. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2. Interacts with EPAS1. Interacts with CBFA2T3 and HIF1A. Cytoplasm Nucleus Note=Mainly cytoplasmic. Shuttles between the nucleus and cytoplasm. Nuclear export requires functional XPO1. Expressed in heart, brain liver, skeletal muscle and kidney. Low levels were detected in the lung. Constitutively expressed during differentiation of C2C12 skeletal myocytes. Induced by growth factors in cultured vascular smooth muscle. Up-regulated in proliferating myoblasts induced to form differentiated myotubes. The beta(2)beta(3) 'finger-like' loop domain is important for substrate (HIFs' CODD/NODD) selectivity. S-nitrosylation inhibits the enzyme activity up to 60% under aerobic conditions. Chelation of Fe(2+) has no effect on the S- nitrosylation. It is uncertain whether nitrosylation occurs on Cys-300 or Cys-303. Null mice are smaller than wild type and are erythematous with some animals having evidence of retroperitoneal hemorrhage. The resulting polycythemia can cause thrombosis and cardiac failure and animals die off after 10 weeks. Erythropoietin levels are increased in kidneys but not in livers. In neonatal null mice exposed to 75% oxygen, there are high levels of HIF1A nuclear abundance in retinal tissues accompanied by well-preserved retinal microvessels compared to wild type where oxygen-treated retinas exhibit reverse effects with increased risks of retinopathy. Sequence=AAH06903.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; response to hypoxia iron ion binding nucleus cytoplasm cytosol cellular iron ion homeostasis ferrous iron binding postsynaptic density oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors peptidyl-proline hydroxylation to 4-hydroxy-L-proline enzyme binding L-ascorbic acid binding peptidyl-proline dioxygenase activity peptidyl-proline 4-dioxygenase activity oxygen homeostasis positive regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter metal ion binding dioxygenase activity negative regulation of cyclic-nucleotide phosphodiesterase activity cardiac muscle tissue morphogenesis oxidation-reduction process heart trabecula formation ventricular septum morphogenesis labyrinthine layer development response to nitric oxide glutamatergic synapse regulation of protein catabolic process at postsynapse, modulating synaptic transmission regulation of neuron death positive regulation of neuron death negative regulation of CAMKK-AMPK signaling cascade uc012gna.1 uc012gna.2 uc012gna.3 
ENSMUST00000034470.11 Vps26b ENSMUST00000034470.11 VPS26 retromer complex component B (from RefSeq NM_178027.4) ENSMUST00000034470.1 ENSMUST00000034470.10 ENSMUST00000034470.2 ENSMUST00000034470.3 ENSMUST00000034470.4 ENSMUST00000034470.5 ENSMUST00000034470.6 ENSMUST00000034470.7 ENSMUST00000034470.8 ENSMUST00000034470.9 NM_178027 Q3TN45 Q8C0E2 Q8K2V3 VP26B_MOUSE uc009oqd.1 uc009oqd.2 uc009oqd.3 uc009oqd.4 Acts as a component of the retromer cargo-selective complex (CSC) (PubMed:21040701, PubMed:21920005). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (By similarity). May be involved in retrograde transport of SORT1 but not of IGF2R (PubMed:21040701). Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (PubMed:25136126). Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35 (PubMed:21040701, PubMed:21920005, PubMed:18088321, PubMed:20875039). The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform (Probable). The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described SNX-BAR retromer is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex (By similarity). Interacts with VPS29, VPS35, TBC1D5, GOLPH3, SNX27 (PubMed:16190980, PubMed:21040701, PubMed:21920005, PubMed:25136126). Cytoplasm Membrane ; Peripheral membrane protein Early endosome Late endosome Note=Endosomal localization is reported controversially. Does not localize to endosomes (PubMed:16190980). Localizes to early and late endosomal structures (PubMed:21920005, PubMed:18088321). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C0E2-1; Sequence=Displayed; Name=2; IsoId=Q8C0E2-2; Sequence=VSP_019927; Ubiquitously expressed in developing embryo and adult. Highly expressed in brain. Belongs to the VPS26 family. cytoplasm endosome early endosome late endosome cytosol intracellular protein transport protein transport membrane retromer complex retrograde transport, endosome to Golgi phagocytic vesicle cellular response to interferon-gamma uc009oqd.1 uc009oqd.2 uc009oqd.3 uc009oqd.4 
ENSMUST00000034472.16 Jam3 ENSMUST00000034472.16 junction adhesion molecule 3 (from RefSeq NM_023277.4) ENSMUST00000034472.1 ENSMUST00000034472.10 ENSMUST00000034472.11 ENSMUST00000034472.12 ENSMUST00000034472.13 ENSMUST00000034472.14 ENSMUST00000034472.15 ENSMUST00000034472.2 ENSMUST00000034472.3 ENSMUST00000034472.4 ENSMUST00000034472.5 ENSMUST00000034472.6 ENSMUST00000034472.7 ENSMUST00000034472.8 ENSMUST00000034472.9 JAM3_MOUSE NM_023277 Q8BT59 Q9D1M9 Q9D8B7 Q9EPK4 uc009oqj.1 uc009oqj.2 uc009oqj.3 uc009oqj.4 Junctional adhesion protein that mediates heterotypic cell- cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed:15372036, PubMed:16093349). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (PubMed:16297198). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (PubMed:15372036, PubMed:15994945). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:16093349). Plays a role in angiogenesis (PubMed:15994945). Plays a role in the regulation of cell migration (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). [Soluble form of JAM-C]: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis. Interacts with ITGAM (By similarity). Interacts with GORASP2 (PubMed:28617811). Cell membrane ingle-pass type I membrane protein Cell junction Cell junction, desmosome Cell junction, tight junction te=Detected in the acrosome region in developing spermatids (PubMed:28617811). In epithelial cells, it is expressed at desmosomes but not at tight junctions (By similarity). Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (By similarity). [Soluble form of JAM-C]: Secreted Colocalizes with Jam2 near the lumen of seminiferous tubulues. Detected at junctional plaques that correspond to cell-cell contacts between spermatids and Sertoli cells (PubMed:15372036, PubMed:28617811). Detected on endothelial cells, in brain vessels and kidney glomeruli (at protein level) (PubMed:11053409, PubMed:11739175). Detected in heart, lung, liver, kidney, testis, thymus, lymph node and Peyer patch (PubMed:11053409, PubMed:11739175). Endothelial cells (PubMed:11739175). Detected in diploid pre-meiotic spermatocytes, haploid spermatids and elongated spermatids (PubMed:28617811, PubMed:15372036). Restricted to junctional plaques in the heads of elongated spermatids (at protein level) (PubMed:15372036). The Ig-like V-type domain mediates interaction with JAM2. Proteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17; the release of soluble JAM3 is increased by pro-inflammatory factors. N-glycosylated. S-palmitoylated by ZDHHC7. S-palmitoylation promotes expression at tight junctions. Important mortality during the postnatal period; about 40% of the mutant mice survive. Mutant males are infertile; they have strongly reduced testis size and fail to produce mature sperm cells. Developing spermatids fail to become polarized, and do not form acrosomes. Belongs to the immunoglobulin superfamily. angiogenesis neutrophil homeostasis adaptive immune response myeloid progenitor cell differentiation leukocyte migration involved in inflammatory response integrin binding protein binding extracellular region extracellular space Golgi apparatus plasma membrane integral component of plasma membrane microvillus cell-cell junction bicellular tight junction cell adhesion cell-matrix adhesion spermatogenesis spermatid development cell surface membrane integral component of membrane cell migration transmission of nerve impulse establishment of cell polarity cell junction desmosome cell differentiation axon regeneration filamentous actin paranodal junction negative regulation of integrin activation negative regulation of cell adhesion mediated by integrin heterotypic cell-cell adhesion adherens junction assembly protein localization to cell surface myelination protein homodimerization activity Schmidt-Lanterman incisure cell-cell contact zone apical protein localization protein heterodimerization activity occluding junction regulation of neutrophil chemotaxis regulation of actin cytoskeleton organization by cell-cell adhesion granulocyte migration cell-cell adhesion protein binding involved in cell-cell adhesion protein localization to cell junction uc009oqj.1 uc009oqj.2 uc009oqj.3 uc009oqj.4 
ENSMUST00000034473.7 Spata19 ENSMUST00000034473.7 spermatogenesis associated 19, transcript variant 1 (from RefSeq NM_029299.3) ENSMUST00000034473.1 ENSMUST00000034473.2 ENSMUST00000034473.3 ENSMUST00000034473.4 ENSMUST00000034473.5 ENSMUST00000034473.6 NM_029299 Q810M9 Q9DAQ9 SPT19_MOUSE Spergen1 uc009oqo.1 uc009oqo.2 uc009oqo.3 uc009oqo.4 Essential for sperm motility and male fertility (PubMed:26265198). Plays an important role in sperm motility by regulating the organization and function of the mitochondria and is also required for correct sperm midpiece assembly (PubMed:26265198). Mitochondrion outer membrane Mitochondrion Cell projection, cilium, flagellum Note=Localizes to the midpiece of the sperm flagellum. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DAQ9-1; Sequence=Displayed; Name=2; IsoId=Q9DAQ9-2; Sequence=VSP_020764, VSP_020765; Expressed specifically in adult testis (at protein level). Male mice are infertile, their sperms exhibit disorganized mitochondrial structure and the sperm-abundance of mitochondrial proteins and activities of mitochondrial respiratory chain complex IV, and ATP levels are significantly reduced (PubMed:26265198). Epididymal sperm possess seriously disrupted midpieces, leading to a severe reduction in sperm motility and infertility (PubMed:26265198). molecular_function cellular_component mitochondrion mitochondrial outer membrane multicellular organism development spermatogenesis biological_process membrane cell differentiation uc009oqo.1 uc009oqo.2 uc009oqo.3 uc009oqo.4 
ENSMUST00000034478.3 St14 ENSMUST00000034478.3 suppression of tumorigenicity 14 (colon carcinoma) (from RefSeq NM_011176.4) ENSMUST00000034478.1 ENSMUST00000034478.2 NM_011176 Q543E3 Q543E3_MOUSE St14 uc009ori.1 uc009ori.2 uc009ori.3 Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Reaction=Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.; EC=3.4.21.109; Evidence=; Interacts with CDCP1. May interact with TMEFF1. Membrane ; Single- pass type II membrane protein Belongs to the peptidase S1 family. Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane basolateral plasma membrane hydrolase activity extrinsic component of plasma membrane keratinocyte differentiation uc009ori.1 uc009ori.2 uc009ori.3 
ENSMUST00000034487.4 Mmp20 ENSMUST00000034487.4 matrix metallopeptidase 20 (enamelysin) (from RefSeq NM_013903.2) A7MCV5 ENSMUST00000034487.1 ENSMUST00000034487.2 ENSMUST00000034487.3 MMP20_MOUSE NM_013903 P57748 uc009ocu.1 uc009ocu.2 uc009ocu.3 This gene encodes a member of the matrix metalloproteinase family of zinc-dependent endopeptidases capable of degrading extracellular matrix proteins. This gene is expressed specifically in the ameloblasts and odontoblasts, and the encoded protein is an inactive zymogen that requires proteolytic removal of a N-terminal propeptide to become enzymatically active. Mice lacking the encoded protein display an amelogenesis imperfecta phenotype. [provided by RefSeq, Oct 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF155933.1, BC152335.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 Calcium ions per subunit. ; Secreted, extracellular space, extracellular matrix Expressed specifically in the enamel organ. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. Autoactivates at least at the 106-Asn-|-Tyr-107 site. Belongs to the peptidase M10A family. metalloendopeptidase activity extracellular region proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity extracellular matrix disassembly protein catabolic process extracellular matrix organization collagen catabolic process extracellular matrix metal ion binding amelogenesis uc009ocu.1 uc009ocu.2 uc009ocu.3 
ENSMUST00000034488.4 Mmp10 ENSMUST00000034488.4 matrix metallopeptidase 10 (from RefSeq NM_019471.3) ENSMUST00000034488.1 ENSMUST00000034488.2 ENSMUST00000034488.3 MMP10_MOUSE NM_019471 O55123 uc009ocq.1 uc009ocq.2 uc009ocq.3 uc009ocq.4 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. The lack of encoded protein in mice promotes experimental lung cancer formation, exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK020292.1, Y13185.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN01164133 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase. Reaction=Similar to stromelysin 1, but action on collagen types III, IV and V is weak.; EC=3.4.24.22; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Secreted, extracellular space, extracellular matrix Expressed in small intestine. Weak levels in heart and lung. By wounding. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. Belongs to the peptidase M10A family. metalloendopeptidase activity extracellular region proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity extracellular matrix organization regulation of cell migration collagen catabolic process extracellular matrix metal ion binding uc009ocq.1 uc009ocq.2 uc009ocq.3 uc009ocq.4 
ENSMUST00000034497.9 Mmp3 ENSMUST00000034497.9 matrix metallopeptidase 3 (from RefSeq NM_010809.3) ENSMUST00000034497.1 ENSMUST00000034497.2 ENSMUST00000034497.3 ENSMUST00000034497.4 ENSMUST00000034497.5 ENSMUST00000034497.6 ENSMUST00000034497.7 ENSMUST00000034497.8 Mmp3 NM_010809 Q922W6 Q922W6_MOUSE uc009oco.1 uc009oco.2 uc009oco.3 uc009oco.4 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded protein is activated by the removal of an N-temrinal activation peptide to generate a zinc-dependent endopeptidase with a broad range of substrates such as proteoglycans, laminin, fibronectin, elastin, and collagens. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X63162.1, AK148467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Reaction=Preferential cleavage where P1', P2' and P3' are hydrophobic residues.; EC=3.4.24.17; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Can bind about 5 Ca(2+) ions per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. Belongs to the peptidase M10A family. endopeptidase activity metalloendopeptidase activity proteolysis peptidase activity metallopeptidase activity zinc ion binding negative regulation of hydrogen peroxide metabolic process hydrolase activity extracellular matrix positive regulation of protein complex assembly metal ion binding uc009oco.1 uc009oco.2 uc009oco.3 uc009oco.4 
ENSMUST00000034510.9 Nectin1 ENSMUST00000034510.9 nectin cell adhesion molecule 1, transcript variant 1 (from RefSeq NM_021424.3) ENSMUST00000034510.1 ENSMUST00000034510.2 ENSMUST00000034510.3 ENSMUST00000034510.4 ENSMUST00000034510.5 ENSMUST00000034510.6 ENSMUST00000034510.7 ENSMUST00000034510.8 Hvec NECT1_MOUSE NM_021424 Nectin1 Prr1 Pvrl1 Q6P9M9 Q9ERL5 Q9JI17 Q9JKF6 uc009pbj.1 uc009pbj.2 uc009pbj.3 Involved in cell adhesion and synaptogegesis. Has some neurite outgrowth-promoting activity. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells. Cis- and trans-homodimer. Can form trans-heterodimers with NECTIN3. Interaction between NECTIN1 and NECTIN3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Ig- like C2-type domain 2) with FGFR1, FGFR2 and FGFR3. Interacts (via Cytoplasmic domain) with AFDN, providing a connection with the actin cytoskeleton. Interacts with HSV glycoprotein D (gD). Cell membrane ; Single-pass type I membrane protein Presynaptic cell membrane Ig-like C2-type 2 mediates neurite outgrowth through binding, induction of phosphorylation, and activation of FGFR. Belongs to the nectin family. lens morphogenesis in camera-type eye desmosome organization protein binding plasma membrane cell-cell junction cell-cell adherens junction iron ion transport cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules axon guidance membrane integral component of membrane viral process virion attachment to host cell cell junction carbohydrate binding axon dendrite growth cone membrane signaling receptor activity presynaptic membrane identical protein binding protein homodimerization activity neuron projection intracellular membrane-bounded organelle apical junction complex cell-cell contact zone synapse viral entry into host cell virion binding protein heterodimerization activity camera-type eye morphogenesis cell adhesion molecule binding regulation of synapse assembly retina development in camera-type eye enamel mineralization cell-cell adhesion integral component of presynaptic active zone membrane protein localization to cell junction uc009pbj.1 uc009pbj.2 uc009pbj.3 
ENSMUST00000034511.7 Trim29 ENSMUST00000034511.7 tripartite motif-containing 29 (from RefSeq NM_023655.2) ENSMUST00000034511.1 ENSMUST00000034511.2 ENSMUST00000034511.3 ENSMUST00000034511.4 ENSMUST00000034511.5 ENSMUST00000034511.6 NM_023655 Q8CEE2 Q8R2Q0 Q922Y3 Q99PN5 Q9CSC9 TRI29_MOUSE uc009pbi.1 uc009pbi.2 uc009pbi.3 uc009pbi.4 Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. Interacts with VIM and HINT1. Interacts with IKBKG/NEMO. Interacts with STING1. Cytoplasm Lysosome Note=Colocalizes with intermediate filaments. Absence of TRIM29 enhances macrophage production of type I interferons and protects mice from infection with influenza virus. Sequence=BAC25956.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter p53 binding immune system process cytoplasm lysosome zinc ion binding identical protein binding innate immune response metal ion binding negative regulation of protein localization to nucleus uc009pbi.1 uc009pbi.2 uc009pbi.3 uc009pbi.4 
ENSMUST00000034512.7 Oaf ENSMUST00000034512.7 out at first homolog (from RefSeq NM_178644.3) D9Ucla1 ENSMUST00000034512.1 ENSMUST00000034512.2 ENSMUST00000034512.3 ENSMUST00000034512.4 ENSMUST00000034512.5 ENSMUST00000034512.6 NM_178644 OAF_MOUSE Q3UD27 Q8QZR4 uc009pbf.1 uc009pbf.2 uc009pbf.3 Belongs to the OAF family. molecular_function biological_process uc009pbf.1 uc009pbf.2 uc009pbf.3 
ENSMUST00000034519.13 Crtam ENSMUST00000034519.13 Crtam (from geneSymbol) AF001104 Crtam E9QPS7 E9QPS7_MOUSE ENSMUST00000034519.1 ENSMUST00000034519.10 ENSMUST00000034519.11 ENSMUST00000034519.12 ENSMUST00000034519.2 ENSMUST00000034519.3 ENSMUST00000034519.4 ENSMUST00000034519.5 ENSMUST00000034519.6 ENSMUST00000034519.7 ENSMUST00000034519.8 ENSMUST00000034519.9 uc292gfe.1 uc292gfe.2 membrane integral component of membrane uc292gfe.1 uc292gfe.2 
ENSMUST00000034521.8 Jhy ENSMUST00000034521.8 junctional cadherin complex regulator, transcript variant 3 (from RefSeq NM_001357360.1) E0CX29 E9Q793 ENSMUST00000034521.1 ENSMUST00000034521.2 ENSMUST00000034521.3 ENSMUST00000034521.4 ENSMUST00000034521.5 ENSMUST00000034521.6 ENSMUST00000034521.7 JHY_MOUSE Jhy NM_001357360 Q9CUE4 uc009pac.1 uc009pac.2 uc009pac.3 Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. Expressed in the brain, specifically in hypothalamus, pineal gland, and ependymal cells of the aqueduct of Sylvius, as well as in the choroid plexus of the third ventricle. Expressed in the ependymal cells lining the lateral ventricles (at protein level). molecular_function cellular_component brain development cell projection organization ciliary basal body organization cerebrospinal fluid secretion axoneme assembly uc009pac.1 uc009pac.2 uc009pac.3 
ENSMUST00000034522.8 Clmp ENSMUST00000034522.8 CXADR-like membrane protein (from RefSeq NM_133733.5) Acam Asam Asp5 CLMP_MOUSE ENSMUST00000034522.1 ENSMUST00000034522.2 ENSMUST00000034522.3 ENSMUST00000034522.4 ENSMUST00000034522.5 ENSMUST00000034522.6 ENSMUST00000034522.7 NM_133733 Q8R373 Q920S5 uc009ozt.1 uc009ozt.2 uc009ozt.3 May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development (By similarity). Cell junction, tight junction Cell membrane ; Single-pass type I membrane protein Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in the heart and brain, at intermediate levels in the lung, skeletal muscle, kidney and testis and at low levels in the liver and spleen. Up-regulated in mature adipocytes and adipocyte tissue of obese animals. molecular_function cytoplasmic microtubule plasma membrane bicellular tight junction membrane integral component of membrane cell junction digestive tract development uc009ozt.1 uc009ozt.2 uc009ozt.3 
ENSMUST00000034524.5 Rexo2 ENSMUST00000034524.5 RNA exonuclease 2, transcript variant 1 (from RefSeq NM_024233.4) ENSMUST00000034524.1 ENSMUST00000034524.2 ENSMUST00000034524.3 ENSMUST00000034524.4 NM_024233 ORN_MOUSE Q9D8S4 Smfn uc009pia.1 uc009pia.2 uc009pia.3 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:31588022). Binds and degrades longer oligonucleotides with a lower affinity (By similarity). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (By similarity). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022). Essential for embryonic development (PubMed:31588022). Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Homodimer (By similarity). Homotetramer (By similarity). Mitochondrion intermembrane space Mitochondrion matrix Mitochondrion Cytoplasm Nucleus Causes embryonic lethality before E8.5 (PubMed:31588022). Heart- and skeletal-muscle-specific knockout mice show elevated concentrations of the RNA dinucleotide pApA in the mitochondria purified from the heart (PubMed:31588022). Belongs to the oligoribonuclease family. 3'-5'-exoribonuclease activity nucleic acid binding nuclease activity exonuclease activity nucleus nucleolus mitochondrion mitochondrial intermembrane space mitochondrial matrix focal adhesion nucleobase-containing compound metabolic process 3'-5' exonuclease activity hydrolase activity nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic uc009pia.1 uc009pia.2 uc009pia.3 
ENSMUST00000034527.14 Nxpe2 ENSMUST00000034527.14 neurexophilin and PC-esterase domain family, member 2 (from RefSeq NM_030069.3) A0A0R4J0E5 A0A0R4J0E5_MOUSE ENSMUST00000034527.1 ENSMUST00000034527.10 ENSMUST00000034527.11 ENSMUST00000034527.12 ENSMUST00000034527.13 ENSMUST00000034527.2 ENSMUST00000034527.3 ENSMUST00000034527.4 ENSMUST00000034527.5 ENSMUST00000034527.6 ENSMUST00000034527.7 ENSMUST00000034527.8 ENSMUST00000034527.9 NM_030069 Nxpe2 uc009phw.1 uc009phw.2 uc009phw.3 uc009phw.4 Belongs to the NXPE family. membrane integral component of membrane uc009phw.1 uc009phw.2 uc009phw.3 uc009phw.4 
ENSMUST00000034529.14 Cul5 ENSMUST00000034529.14 cullin 5, transcript variant 1 (from RefSeq NM_027807.4) Cul5 ENSMUST00000034529.1 ENSMUST00000034529.10 ENSMUST00000034529.11 ENSMUST00000034529.12 ENSMUST00000034529.13 ENSMUST00000034529.2 ENSMUST00000034529.3 ENSMUST00000034529.4 ENSMUST00000034529.5 ENSMUST00000034529.6 ENSMUST00000034529.7 ENSMUST00000034529.8 ENSMUST00000034529.9 G3X914 G3X914_MOUSE NM_027807 uc009pmi.1 uc009pmi.2 uc009pmi.3 uc009pmi.4 Protein modification; protein ubiquitination. Belongs to the cullin family. ubiquitin-dependent protein catabolic process cullin-RING ubiquitin ligase complex Cul5-RING ubiquitin ligase complex ubiquitin protein ligase binding uc009pmi.1 uc009pmi.2 uc009pmi.3 uc009pmi.4 
ENSMUST00000034533.7 Kcnj5 ENSMUST00000034533.7 potassium inwardly-rectifying channel, subfamily J, member 5, transcript variant 1 (from RefSeq NM_010605.6) ENSMUST00000034533.1 ENSMUST00000034533.2 ENSMUST00000034533.3 ENSMUST00000034533.4 ENSMUST00000034533.5 ENSMUST00000034533.6 Girk4 KCNJ5_MOUSE NM_010605 P48545 P97508 Q3TPX9 uc009orw.1 uc009orw.2 uc009orw.3 This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. May associate with GIRK1 and GIRK2 to form a G-protein- activated heteromultimer pore-forming unit. The resulting inward current is much larger. Membrane ; Multi- pass membrane protein Predominantly atrial and pancreatic expression. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily. inward rectifier potassium channel activity voltage-gated ion channel activity ion transport potassium ion transport voltage-gated potassium channel complex external side of plasma membrane G-protein activated inward rectifier potassium channel activity membrane integral component of membrane T-tubule regulation of ion transmembrane transport voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization regulation of heart rate by cardiac conduction membrane repolarization during atrial cardiac muscle cell action potential potassium ion import across plasma membrane uc009orw.1 uc009orw.2 uc009orw.3 
ENSMUST00000034534.13 Ets1 ENSMUST00000034534.13 E26 avian leukemia oncogene 1, 5' domain, transcript variant 1 (from RefSeq NM_011808.3) ENSMUST00000034534.1 ENSMUST00000034534.10 ENSMUST00000034534.11 ENSMUST00000034534.12 ENSMUST00000034534.2 ENSMUST00000034534.3 ENSMUST00000034534.4 ENSMUST00000034534.5 ENSMUST00000034534.6 ENSMUST00000034534.7 ENSMUST00000034534.8 ENSMUST00000034534.9 Ets1 NM_011808 Q540Q5 Q540Q5_MOUSE uc009osb.1 uc009osb.2 uc009osb.3 Cytoplasm Nucleus Belongs to the ETS family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding response to hypoxia DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated female pregnancy positive regulation of cell proliferation response to wounding response to mechanical stimulus positive regulation of endothelial cell migration positive regulation of gene expression regulation of extracellular matrix disassembly hypothalamus development pituitary gland development positive regulation of cell migration PML body organization response to estradiol response to laminar fluid shear stress histone acetyltransferase binding identical protein binding positive regulation of blood vessel endothelial cell migration sequence-specific DNA binding estrous cycle positive regulation of erythrocyte differentiation regulation of angiogenesis positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell motility positive regulation of inflammatory response positive regulation of cellular component movement angiogenesis involved in wound healing pri-miRNA transcription from RNA polymerase II promoter cellular response to hydrogen peroxide response to interleukin-1 positive regulation of leukocyte adhesion to vascular endothelial cell uc009osb.1 uc009osb.2 uc009osb.3 
ENSMUST00000034537.8 St3gal4 ENSMUST00000034537.8 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (from RefSeq NM_009178.4) ENSMUST00000034537.1 ENSMUST00000034537.2 ENSMUST00000034537.3 ENSMUST00000034537.4 ENSMUST00000034537.5 ENSMUST00000034537.6 ENSMUST00000034537.7 NM_009178 P97354 Q61325 Q91Y74 SIA4C_MOUSE Siat4c uc009osm.1 uc009osm.2 uc009osm.3 A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:12097641) (By similarity). Catalyzes the transfer of sialic acid (N-acetyl- neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc- terminated glycoconjugates through an alpha2-3 linkage (PubMed:9184827) (By similarity). Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (PubMed:12097641). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E- selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin- mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912). Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (PubMed:18519646). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (By similarity). Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (By similarity). Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha- neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D- galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:52380, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:136588, ChEBI:CHEBI:136589; EC=2.4.3.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52381; Evidence=; Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha- neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:21616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133470, ChEBI:CHEBI:139596; EC=2.4.3.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21617; Evidence=; Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha- neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D- glucosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:52316, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133507, ChEBI:CHEBI:136545; EC=2.4.3.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52317; Evidence=; Reaction=a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:18021, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:77709, ChEBI:CHEBI:78445; EC=2.4.3.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18022; Evidence=; Reaction=a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:47560, ChEBI:CHEBI:15378, ChEBI:CHEBI:27938, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47561; Evidence=; Reaction=a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1c (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:47588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:87789, ChEBI:CHEBI:87791; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47589; Evidence=; Reaction=a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+); Xref=Rhea:RHEA:65432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:90376, ChEBI:CHEBI:90390; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65433; Evidence=; Reaction=a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta- neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:18913, ChEBI:CHEBI:15378, ChEBI:CHEBI:17006, ChEBI:CHEBI:57812, ChEBI:CHEBI:58665, ChEBI:CHEBI:60377; EC=2.4.3.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18914; Evidence=; Kinetic parameters: KM=0.75 mM for Gal-beta-1,3-GlcNAc ; KM=0.22 mM for Gal-beta-1,4-GlcNAc ; KM=3.0 mM for Gal-beta-1,3-GalNAc ; Note=Relative Vmax is 2:5:1 for Gal-beta-1,3-GlcNAc, Gal-beta-1,4- GlcNAc and Gal-beta-1,3-GalNAc as substrate, respectively. ; pH dependence: Optimum pH is 6.4. ; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Note=Membrane-bound form in trans cisternae of Golgi. Broadly expressed among tissues with highest levels in the small intestine and colon. Knockout mice suffer from bleeding disorders and thrombocytopenia due to deficient ASGPR-mediated clearance of plasma VWF/von Willebrand factor. Belongs to the glycosyltransferase 29 family. Name=Functional Glycomics Gateway - GTase; Note=ST3Gal IV; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_645"; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity Golgi apparatus protein glycosylation N-acetyllactosaminide alpha-2,3-sialyltransferase activity sialyltransferase activity glycoprotein biosynthetic process glycolipid biosynthetic process oligosaccharide biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups lipid glycosylation Golgi cisterna membrane monosialoganglioside sialyltransferase activity cognition sialylation protein sialylation uc009osm.1 uc009osm.2 uc009osm.3 
ENSMUST00000034539.12 Dcps ENSMUST00000034539.12 decapping enzyme, scavenger (from RefSeq NM_027030.2) DCPS_MOUSE Dcs1 ENSMUST00000034539.1 ENSMUST00000034539.10 ENSMUST00000034539.11 ENSMUST00000034539.2 ENSMUST00000034539.3 ENSMUST00000034539.4 ENSMUST00000034539.5 ENSMUST00000034539.6 ENSMUST00000034539.7 ENSMUST00000034539.8 ENSMUST00000034539.9 Hint5 NM_027030 Q8C5I7 Q9DAR7 uc009osp.1 uc009osp.2 uc009osp.3 Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7- methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7- methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death. Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP; Xref=Rhea:RHEA:65388, Rhea:RHEA-COMP:17165, Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58285, ChEBI:CHEBI:156461, ChEBI:CHEBI:167616; EC=3.6.1.59; Evidence=; The hydrolytic product 7-methylguanosine diphosphate (m7GDP) efficiently inhibits the decapping scavenger activity and acts as a competitive inhibitor in vitro. Inhibited by 2,4-diaminoquinazoline. Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1. Cytoplasm Nucleus Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner. The C-terminal histidine triad (HIT) motif and the N-terminal domain are required for the decapping activity. The N-terminus is necessary but not sufficient for binding cap structures. Belongs to the HIT family. deadenylation-dependent decapping of nuclear-transcribed mRNA RNA 7-methylguanosine cap binding P-body nucleus nucleoplasm cytoplasm mitochondrion cytosol mRNA processing RNA splicing hydrolase activity cellular response to menadione negative regulation of programmed cell death mRNA cis splicing, via spliceosome m7G(5')pppN diphosphatase activity uc009osp.1 uc009osp.2 uc009osp.3 
ENSMUST00000034541.12 Srpra ENSMUST00000034541.12 signal recognition particle receptor alpha (from RefSeq NM_026130.1) ENSMUST00000034541.1 ENSMUST00000034541.10 ENSMUST00000034541.11 ENSMUST00000034541.2 ENSMUST00000034541.3 ENSMUST00000034541.4 ENSMUST00000034541.5 ENSMUST00000034541.6 ENSMUST00000034541.7 ENSMUST00000034541.8 ENSMUST00000034541.9 NM_026130 Q8VC45 Q921H1 Q9DBG7 SRPRA_MOUSE Srpr Srpra uc009osy.1 uc009osy.2 uc009osy.3 Component of the SRP (signal recognition particle) receptor (By similarity). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (By similarity). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Heterodimer with SRPRB (By similarity). Interacts with the signal recognition particle (SRP) complex subunit SRP54 (By similarity). Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain. The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the signal recognition particle (SRP) complex subunit SRP54 (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). GTPase induced rearrangement of SR drives SRP-mediated cotranslational protein translocation into the ER (By similarity). Belongs to the GTP-binding SRP family. Sequence=AAH12512.1; Type=Erroneous initiation; Evidence=; nucleotide binding GTPase activity signal recognition particle binding GTP binding endoplasmic reticulum signal recognition particle receptor complex endoplasmic reticulum membrane protein targeting SRP-dependent cotranslational protein targeting to membrane intracellular protein transport membrane protein targeting to ER uc009osy.1 uc009osy.2 uc009osy.3 
ENSMUST00000034543.5 Rpusd4 ENSMUST00000034543.5 RNA pseudouridylate synthase domain containing 4 (from RefSeq NM_028040.2) ENSMUST00000034543.1 ENSMUST00000034543.2 ENSMUST00000034543.3 ENSMUST00000034543.4 NM_028040 Q9CWX4 RUSD4_MOUSE Rpusd4 uc009otc.1 uc009otc.2 uc009otc.3 Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Acts on position 39 in mitochondrial tRNA(Phe). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Reaction=uridine in 5S rRNA = pseudouridine in 5S rRNA; Xref=Rhea:RHEA:47036, Rhea:RHEA-COMP:11730, Rhea:RHEA-COMP:11731, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Reaction=a uridine in tRNA = a pseudouridine in tRNA; Xref=Rhea:RHEA:54572, Rhea:RHEA-COMP:13339, Rhea:RHEA-COMP:13934, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Reaction=a uridine in mRNA = a pseudouridine in mRNA; Xref=Rhea:RHEA:56644, Rhea:RHEA-COMP:14658, Rhea:RHEA-COMP:14659, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Interacts with 16S mt-rRNA, mt-tRNA(Phe) and mt-tRNA(Met). Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Mitochondrion matrix Nucleus Cytoplasm Note=Mainly localizes to mitochondrion. Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. Also found in nucleus and cytoplasm. Belongs to the pseudouridine synthase RluA family. pseudouridine synthesis RNA binding mitochondrion mitochondrial matrix tRNA processing RNA modification pseudouridine synthase activity isomerase activity positive regulation of mitochondrial translation uc009otc.1 uc009otc.2 uc009otc.3 
ENSMUST00000034547.6 Acat1 ENSMUST00000034547.6 acetyl-Coenzyme A acetyltransferase 1 (from RefSeq NM_144784.3) ENSMUST00000034547.1 ENSMUST00000034547.2 ENSMUST00000034547.3 ENSMUST00000034547.4 ENSMUST00000034547.5 NM_144784 Q3TE92 Q8QZT1 THIL_MOUSE uc009pmg.1 uc009pmg.2 uc009pmg.3 This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Reaction=2 acetyl-CoA = acetoacetyl-CoA + CoA; Xref=Rhea:RHEA:21036, ChEBI:CHEBI:57286, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21037; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21038; Evidence=; Reaction=acetyl-CoA + propanoyl-CoA = 2-methyl-3-oxobutanoyl-CoA + CoA; Xref=Rhea:RHEA:30719, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57335, ChEBI:CHEBI:57392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30720; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:30721; Evidence=; Activated by potassium ions, but not sodium ions. Lipid metabolism; fatty acid beta-oxidation. Homotetramer. Mitochondrion Succinylation at Lys-265, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5. Belongs to the thiolase-like superfamily. Thiolase family. liver development catalytic activity acetyl-CoA C-acetyltransferase activity acetyl-CoA C-acyltransferase activity mitochondrion mitochondrial inner membrane mitochondrial matrix acetyl-CoA biosynthetic process isoleucine catabolic process lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation brain development response to hormone response to organic cyclic compound coenzyme A metabolic process coenzyme A biosynthetic process C-acetyltransferase activity transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups enzyme binding response to starvation protein homodimerization activity acetyl-CoA catabolic process metal ion binding ketone body catabolic process coenzyme binding protein homooligomerization adipose tissue development metanephric proximal convoluted tubule development propionyl-CoA biosynthetic process uc009pmg.1 uc009pmg.2 uc009pmg.3 
ENSMUST00000034550.5 4930510E17Rik ENSMUST00000034550.5 4930510E17Rik (from geneSymbol) AK015742 ENSMUST00000034550.1 ENSMUST00000034550.2 ENSMUST00000034550.3 ENSMUST00000034550.4 uc292hgu.1 uc292hgu.2 uc292hgu.3 uc292hgu.1 uc292hgu.2 uc292hgu.3 
ENSMUST00000034552.8 Fdx1 ENSMUST00000034552.8 ferredoxin 1, transcript variant 1 (from RefSeq NM_007996.2) ENSMUST00000034552.1 ENSMUST00000034552.2 ENSMUST00000034552.3 ENSMUST00000034552.4 ENSMUST00000034552.5 ENSMUST00000034552.6 ENSMUST00000034552.7 Fdx1 NM_007996 Q545P3 Q545P3_MOUSE uc009plo.1 uc009plo.2 uc009plo.3 uc009plo.4 uc009plo.5 Ferrodoxins are iron-sulfur proteins that facilitate monooxygenase reactions catalyzed by P450 enzymes. The protein encoded by this gene is present in the mitochondrial matrix and transfers electrons from ferredoxin reductase to steroidogenic mitochondrial cytochrome P450 proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Interacts with CYP11A1. mitochondrion cholesterol metabolic process electron carrier activity electron transport chain hormone biosynthetic process iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding uc009plo.1 uc009plo.2 uc009plo.3 uc009plo.4 uc009plo.5 
ENSMUST00000034554.9 Pou2af1 ENSMUST00000034554.9 POU domain, class 2, associating factor 1 (from RefSeq NM_011136.2) ENSMUST00000034554.1 ENSMUST00000034554.2 ENSMUST00000034554.3 ENSMUST00000034554.4 ENSMUST00000034554.5 ENSMUST00000034554.6 ENSMUST00000034554.7 ENSMUST00000034554.8 NM_011136 OBF1_MOUSE Obf-1 Pou2af1 Q64693 uc009plg.1 uc009plg.2 uc009plg.3 Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:23045607). Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (PubMed:23045607). Interacts with POU2F1/OCT1 and POU2F2/OCT2; the interaction increases POU2F1 and POU2F2 transactivation activity. Q64693; P48025: Syk; NbExp=2; IntAct=EBI-943530, EBI-300116; Q64693; Q8IUQ4: SIAH1; Xeno; NbExp=5; IntAct=EBI-943530, EBI-747107; Nucleus B-cell specific. In B cells, expression is highly increased upon activation by LPS or CpG. In the N-terminus possesses a conserved domain OCA for bivalent binding to class II POU domain-containing transcription factors and to an octamer DNA motif. Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. Mutants show severely reduced or absent germinal center B cells in the lung-draining lymphatic nodes when infected by influenza virus. Belongs to the POU2AF family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA binding transcription coactivator activity protein binding nucleus positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor complex uc009plg.1 uc009plg.2 uc009plg.3 
ENSMUST00000034561.11 Alg9 ENSMUST00000034561.11 ALG9 alpha-1,2-mannosyltransferase, transcript variant 1 (from RefSeq NM_133981.3) ALG9_MOUSE Alg9 ENSMUST00000034561.1 ENSMUST00000034561.10 ENSMUST00000034561.2 ENSMUST00000034561.3 ENSMUST00000034561.4 ENSMUST00000034561.5 ENSMUST00000034561.6 ENSMUST00000034561.7 ENSMUST00000034561.8 ENSMUST00000034561.9 NM_133981 Q8BT44 Q8C378 Q8C7G0 Q8VDI9 uc009pkt.1 uc009pkt.2 uc009pkt.3 uc009pkt.4 Catalyzes the transfer of mannose from Dol-P-Man to lipid- linked oligosaccharides. Reaction=a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)- alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D- Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc- diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha- D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man- (1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- alpha-D-GlcNAc-diphosphodolichol + H(+); Xref=Rhea:RHEA:29531, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:12628, Rhea:RHEA-COMP:12629, ChEBI:CHEBI:15378, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:132516, ChEBI:CHEBI:132517; EC=2.4.1.259; Evidence=; Reaction=a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)- alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man- (1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- (1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+); Xref=Rhea:RHEA:29539, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:12630, Rhea:RHEA-COMP:12631, ChEBI:CHEBI:15378, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:132519, ChEBI:CHEBI:132520; EC=2.4.1.261; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the glycosyltransferase 22 family. Sequence=BAC39717.1; Type=Frameshift; Evidence=; mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity mannosylation uc009pkt.1 uc009pkt.2 uc009pkt.3 uc009pkt.4 
ENSMUST00000034564.4 2310030G06Rik ENSMUST00000034564.4 RIKEN cDNA 2310030G06 gene (from RefSeq NM_025865.3) CK052_MOUSE ENSMUST00000034564.1 ENSMUST00000034564.2 ENSMUST00000034564.3 NM_025865 Q9CPS4 Q9D8L0 uc009pki.1 uc009pki.2 uc009pki.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D8L0-1; Sequence=Displayed; Name=2; IsoId=Q9D8L0-2; Sequence=VSP_021875; molecular_function biological_process uc009pki.1 uc009pki.2 uc009pki.3 
ENSMUST00000034567.4 Dlat ENSMUST00000034567.4 dihydrolipoamide S-acetyltransferase (from RefSeq NM_145614.4) Dlat ENSMUST00000034567.1 ENSMUST00000034567.2 ENSMUST00000034567.3 NM_145614 ODP2_MOUSE Q8BMF4 Q8K2G8 Q8R339 Q91ZB1 uc009pka.1 uc009pka.2 uc009pka.3 As part of the pyruvate dehydrogenase complex, catalyzes the transfers of an acetyl group to a lipoic acid moiety. The pyruvate dehydrogenase complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. Reaction=acetyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] = CoA + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein]; Xref=Rhea:RHEA:17017, Rhea:RHEA-COMP:10475, Rhea:RHEA-COMP:10478, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:83100, ChEBI:CHEBI:83111; EC=2.3.1.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17018; Evidence=; Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence=; Note=Binds 2 lipoyl cofactors covalently. ; Part of the pyruvate dehydrogenase complex (PDHc) that is a multi-enzyme complex composed of multiple copies of three enzymes, pyruvate dehydrogenase (subunits PDH1A and PDHB, E1 component), dihydrolipoamide acetyltransferase (DLAT, E2 component), and dihydrolipoamide dehydrogenase (DLD, E3 component) to which is added an additional protein the E3-binding protein (PDHX, E3BP) (By similarity). In terms of structural architecture, the E2 and E3BP components assemble into a 60meric central core with icosahedral symmetry (By similarity). The central core is decorated with E1 and E3 proteins (By similarity). Currently, two alternative models for the E2:E3BP stoichiometry are considered as being either 48:12 (E2(48)-E3BP(12)) or 40:20 (E2(40)-E3BP(20)). Interacts with PDK2 and PDK3. Interacts with SIRT4. Interacts with PDHB (By similarity). Mitochondrion matrix Delipoylated at Lys-131 and Lys-258 by SIRT4, delipoylation decreases the PHD complex activity. Belongs to the 2-oxoacid dehydrogenase family. dihydrolipoyllysine-residue acetyltransferase activity mitochondrion mitochondrial matrix mitochondrial pyruvate dehydrogenase complex carbohydrate metabolic process glucose metabolic process acetyl-CoA biosynthetic process from pyruvate pyruvate metabolic process tricarboxylic acid cycle transferase activity transferase activity, transferring acyl groups sleep dihydrolipoamide S-acyltransferase activity pyruvate dehydrogenase (NAD+) activity identical protein binding myelin sheath pyruvate dehydrogenase complex mitochondrial acetyl-CoA biosynthetic process from pyruvate uc009pka.1 uc009pka.2 uc009pka.3 
ENSMUST00000034570.7 Pts ENSMUST00000034570.7 6-pyruvoyl-tetrahydropterin synthase, transcript variant 1 (from RefSeq NM_011220.3) ENSMUST00000034570.1 ENSMUST00000034570.2 ENSMUST00000034570.3 ENSMUST00000034570.4 ENSMUST00000034570.5 ENSMUST00000034570.6 NM_011220 PTPS_MOUSE Pts Q3UIB6 Q9R1Z7 Q9Z2N2 uc009pjp.1 uc009pjp.2 uc009pjp.3 Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. Reaction=7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8- tetrahydropterin + H(+) + triphosphate; Xref=Rhea:RHEA:22048, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036, ChEBI:CHEBI:58462, ChEBI:CHEBI:136564; EC=4.2.3.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22049; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Kinetic parameters: KM=10.6 uM for dihydroneopterin triphosphate ; Note=kcat is 0.27 (-1) with dihydroneopterin triphosphate as substrate. ; Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3. Homodimer (PubMed:9894812). Homohexamer formed of two homotrimers in a head to head fashion. Phosphorylation of Ser-18 is required for maximal enzyme activity. The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit. Belongs to the PTPS family. 6-pyruvoyltetrahydropterin synthase activity cytoplasm mitochondrion tetrahydrobiopterin biosynthetic process lyase activity identical protein binding protein homodimerization activity metal ion binding uc009pjp.1 uc009pjp.2 uc009pjp.3 
ENSMUST00000034585.7 Apoa4 ENSMUST00000034585.7 apolipoprotein A-IV (from RefSeq NM_007468.2) APOA4_MOUSE ENSMUST00000034585.1 ENSMUST00000034585.2 ENSMUST00000034585.3 ENSMUST00000034585.4 ENSMUST00000034585.5 ENSMUST00000034585.6 NM_007468 P06728 Q91XF8 uc009phd.1 uc009phd.2 uc009phd.3 May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. Homodimer. Secreted. Secreted in plasma. Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid- binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities. There is a polymorphism within a series of imperfect repeats encoding the sequence E-Q-[AV]-Q. Insertions or deletions of 12 nucleotides have given rise to three forms characterized by three (129), four (C57BL/6), or five (M.castaneus) copies of the repeat unit. Belongs to the apolipoprotein A1/A4/E family. innate immune response in mucosa copper ion binding phospholipid binding extracellular region extracellular space cytosol cholesterol biosynthetic process lipid transport response to lipid hydroperoxide leukocyte cell-cell adhesion cholesterol metabolic process lipid binding cell surface positive regulation of cholesterol esterification positive regulation of triglyceride catabolic process cholesterol binding lipid catabolic process antioxidant activity removal of superoxide radicals regulation of intestinal cholesterol absorption phosphatidylcholine binding regulation of cholesterol transport cholesterol efflux phospholipid efflux very-low-density lipoprotein particle high-density lipoprotein particle very-low-density lipoprotein particle remodeling high-density lipoprotein particle assembly negative regulation of plasma lipoprotein particle oxidation response to stilbenoid lipoprotein metabolic process chylomicron cholesterol homeostasis hydrogen peroxide catabolic process identical protein binding protein homodimerization activity reverse cholesterol transport synapse positive regulation of fatty acid biosynthetic process phosphatidylcholine metabolic process positive regulation of lipoprotein lipase activity lipid homeostasis phosphatidylcholine-sterol O-acyltransferase activator activity protein-lipid complex assembly triglyceride homeostasis uc009phd.1 uc009phd.2 uc009phd.3 
ENSMUST00000034588.9 Apoa1 ENSMUST00000034588.9 apolipoprotein A-I (from RefSeq NM_009692.4) APOA1_MOUSE ENSMUST00000034588.1 ENSMUST00000034588.2 ENSMUST00000034588.3 ENSMUST00000034588.4 ENSMUST00000034588.5 ENSMUST00000034588.6 ENSMUST00000034588.7 ENSMUST00000034588.8 NM_009692 O08855 O09042 Q00623 Q8BPD5 uc009phb.1 uc009phb.2 uc009phb.3 uc009phb.4 uc009phb.5 This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is the major protein component of plasma high density lipoprotein (HDL). This protein facilitates the removal of cholesterol and other fats from tissues by transporting them to the liver for excretion. This protein is a cofactor for lecithin cholesterolacyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. Mutations in this gene in humans causes familial HDL deficiency, Tangier disease and familial visceral amyloidosis. Similar clinical features are exhibited by mice with mutations in this gene. This gene is clustered with three other apolipoprotein genes on chromosome 9. [provided by RefSeq, Dec 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI304198.1, AI573781.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Homodimer (By similarity). Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Interacts with SCGB3A2 (By similarity). Interacts with NAXE and YJEFN3 (By similarity). Q00623; Q08460: Kcnma1; NbExp=4; IntAct=EBI-1634106, EBI-1633915; Secreted. Major protein of plasma HDL, also found in chylomicrons. Glycosylated. Palmitoylated. May be acylated. Phosphorylation sites are present in the extracellular medium. [Apolipoprotein A-I]: Mass=27951.3; Mass_error=1.343; Method=Electrospray; Note=Strain C57BL/6. Without methionine sulfoxide.; Evidence=; [Apolipoprotein A-I]: Mass=27923.8; Method=Electrospray; Note=Strain BALB/c. Without methionine sulfoxide.; Evidence=; [Apolipoprotein A-I]: Mass=27965; Method=Electrospray; Note=Strain C57BL/6. With 1 methionine sulfoxide.; Evidence=; [Proapolipoprotein A-I]: Mass=28819.7; Method=Electrospray; Note=Strain C57BL/6. Without methionine sulfoxide.; Evidence=; [Proapolipoprotein A-I]: Mass=28790.7; Method=Electrospray; Note=Strain BALB/c. Without methionine sulfoxide.; Evidence=; Belongs to the apolipoprotein A1/A4/E family. beta-amyloid binding regulation of protein phosphorylation endothelial cell proliferation negative regulation of cytokine secretion involved in immune response receptor binding lipid transporter activity protein binding phospholipid binding phospholipid transporter activity extracellular region extracellular space nucleus cytosol lipid metabolic process phospholipid metabolic process phosphatidylcholine biosynthetic process cholesterol biosynthetic process lipid transport G-protein coupled receptor signaling pathway integrin-mediated signaling pathway high-density lipoprotein particle binding steroid metabolic process cholesterol metabolic process glucocorticoid metabolic process lipid binding cell surface negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of cholesterol esterification positive regulation of cholesterol efflux positive regulation of triglyceride catabolic process negative regulation of very-low-density lipoprotein particle remodeling cholesterol binding phospholipid transport protein oxidation peptidyl-methionine modification enzyme binding lipid storage endocytic vesicle regulation of intestinal cholesterol absorption cholesterol transport adrenal gland development heat shock protein binding animal organ regeneration phosphatidylcholine binding cytoplasmic vesicle regulation of Cdc42 protein signal transduction cholesterol efflux phospholipid efflux negative regulation of heterotypic cell-cell adhesion apolipoprotein receptor binding apolipoprotein A-I receptor binding very-low-density lipoprotein particle low-density lipoprotein particle intermediate-density lipoprotein particle high-density lipoprotein particle discoidal high-density lipoprotein particle spherical high-density lipoprotein particle very-low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling high-density lipoprotein particle assembly positive regulation of Rho protein signal transduction lipoprotein metabolic process lipoprotein biosynthetic process chylomicron cholesterol homeostasis identical protein binding blood vessel endothelial cell migration reverse cholesterol transport chemorepellent activity positive regulation of fatty acid biosynthetic process phosphatidylcholine metabolic process negative regulation of interleukin-1 beta secretion negative regulation of inflammatory response positive regulation of phagocytosis protein stabilization negative chemotaxis positive regulation of lipoprotein lipase activity vitamin transport positive regulation of hydrolase activity negative regulation of hydrolase activity positive regulation of stress fiber assembly phospholipid homeostasis lipase inhibitor activity negative regulation of lipase activity phosphatidylcholine-sterol O-acyltransferase activator activity negative regulation of cell adhesion molecule production negative regulation of response to cytokine stimulus triglyceride homeostasis cholesterol import high-density lipoprotein particle receptor binding lipoprotein particle binding positive regulation of substrate adhesion-dependent cell spreading positive regulation of phospholipid efflux protein localization axon regeneration uc009phb.1 uc009phb.2 uc009phb.3 uc009phb.4 uc009phb.5 
ENSMUST00000034590.4 Tagln ENSMUST00000034590.4 transgelin (from RefSeq NM_011526.5) ENSMUST00000034590.1 ENSMUST00000034590.2 ENSMUST00000034590.3 NM_011526 P37804 Q545W0 Sm22 Sm22a TAGL_MOUSE uc009pgs.1 uc009pgs.2 uc009pgs.3 uc009pgs.4 This gene encodes a smooth muscle cell-specific cytoskeletal protein. The encoded protein is structurally similar to calponin, an actin-binding protein. In mouse models of atherosclerosis the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis. [provided by RefSeq, Mar 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK077235.1, AK002880.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Actin cross-linking/gelling protein. Cytoplasm By growth factors. Belongs to the calponin family. cytoplasm epithelial cell differentiation actin filament binding cytoskeleton organization uc009pgs.1 uc009pgs.2 uc009pgs.3 uc009pgs.4 
ENSMUST00000034591.11 Bace1 ENSMUST00000034591.11 beta-site APP cleaving enzyme 1, transcript variant 1 (from RefSeq NM_011792.7) BACE1_MOUSE Bace Bace1 ENSMUST00000034591.1 ENSMUST00000034591.10 ENSMUST00000034591.2 ENSMUST00000034591.3 ENSMUST00000034591.4 ENSMUST00000034591.5 ENSMUST00000034591.6 ENSMUST00000034591.7 ENSMUST00000034591.8 ENSMUST00000034591.9 NM_011792 P56818 Q544D0 uc009pgh.1 uc009pgh.2 uc009pgh.3 uc009pgh.4 uc009pgh.5 This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality. [provided by RefSeq, Nov 2015]. Responsible for the proteolytic processing of the amyloid precursor protein (APP) (PubMed:29325091). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:29325091). Cleaves CHL1 (PubMed:29325091). Reaction=Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|- Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.; EC=3.4.23.46; Evidence=; Inhibited by RTN3 and RTN4. Monomer. Interacts (via DXXLL motif) with GGA1, GGA2 and GGA3 (via their VHS domain); the interaction highly increases when BACE1 is phosphorylated at Ser-498. Interacts with RTN1; RTN2; RTN3 and RTN4; the interaction leads to inhibition of amyloid precursor protein processing (By similarity). Interacts with SNX6. Interacts with PCSK9. Interacts with NAT8 and NAT8B. Interacts with BIN1 (By similarity). Interacts (via extracellular domain) with ADAM10 (via extracellular domain) (PubMed:29325091). Interacts with SORL1; this interaction may affect binding with APP and hence reduce APP cleavage (PubMed:16407538). Interacts with NRDC AND NRG1 (PubMed:19935654). Cell membrane ; Single-pass type I membrane protein Golgi apparatus, trans-Golgi network Endoplasmic reticulum Endosome Late endosome Early endosome Cell surface Cytoplasmic vesicle membrane Membrane raft Lysosome Recycling endosome Cell projection, axon Cell projection, dendrite Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (By similarity). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (PubMed:25592972). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (By similarity). Expressed in the brain, specifically in neurons and astrocytes (at protein level). In brain oxidative stress induced by amyloid-beta deposition during aging increases protein levels. DXXLL motif is required for a proper endocytosis and retrograde transport to the trans-Golgi network, as well as for regulation of lysosomal degradation. The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP. N-Glycosylated (By similarity). Addition of a bisecting N- acetylglucosamine by MGAT3 blocks lysosomal targeting, further degradation and is required for maintaining stability under stress conditions (PubMed:25592972, PubMed:26467158). Palmitoylation mediates lipid raft localization. Acetylated in the endoplasmic reticulum at Lys-126, Lys-275, Lys- 279, Lys-285, Lys-299, Lys-300 and Lys-307 (PubMed:20826464). Acetylation by NAT8 and NAT8B is transient and deacetylation probably occurs in the Golgi. Acetylation regulates the maturation, the transport to the plasma membrane, the stability and the expression of the protein. Ubiquitinated at Lys-501, ubiquitination leads to lysosomal degradation. Monoubiquitinated and 'Lys-63'-linked polyubitinated. Deubiquitnated by USP8; inhibits lysosomal degradation. Phosphorylation at Ser-498 is required for interaction with GGA1 and retrograded transport from endosomal compartments to the trans- Golgi network. Non-phosphorylated BACE1 enters a direct recycling route to the cell surface. Mice show a higher mortality rate early in life. Belongs to the peptidase A1 family. beta-amyloid binding endopeptidase activity aspartic-type endopeptidase activity protein binding lysosome endosome early endosome late endosome multivesicular body endoplasmic reticulum Golgi apparatus trans-Golgi network plasma membrane integral component of plasma membrane proteolysis membrane protein ectodomain proteolysis memory synaptic vesicle peptidase activity response to radiation cell surface response to lead ion membrane integral component of membrane hydrolase activity enzyme binding protein catabolic process axon dendrite cytoplasmic vesicle membrane cytoplasmic vesicle amyloid precursor protein catabolic process cell projection neuronal cell body positive regulation of neuron apoptotic process membrane raft regulation of synaptic plasticity beta-amyloid metabolic process modulation of synaptic transmission detection of mechanical stimulus involved in sensory perception of pain recycling endosome prepulse inhibition cellular response to copper ion cellular response to manganese ion presynapse cellular response to beta-amyloid regulation of synaptic vesicle exocytosis uc009pgh.1 uc009pgh.2 uc009pgh.3 uc009pgh.4 uc009pgh.5 
ENSMUST00000034592.11 Dscaml1 ENSMUST00000034592.11 DS cell adhesion molecule like 1 (from RefSeq NM_001081270.2) DSCL1_MOUSE ENSMUST00000034592.1 ENSMUST00000034592.10 ENSMUST00000034592.2 ENSMUST00000034592.3 ENSMUST00000034592.4 ENSMUST00000034592.5 ENSMUST00000034592.6 ENSMUST00000034592.7 ENSMUST00000034592.8 ENSMUST00000034592.9 NM_001081270 Q4VA61 uc009pfz.1 uc009pfz.2 uc009pfz.3 Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (PubMed:19945391). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). Homodimer; mediates homophilic interactions to promote cell adhesion. Cell membrane ; Single-pass type I membrane protein Synapse In the retina, expressed in the rod photoreceptors, AII amacrine cells and rod bipolar cells (at protein level). The inner nuclear and inner plexiform layers in the retina are disorganised at postnatal day 20 (P20). AII amacrine cell populations are randomly distributed or pulled into clumps and rod bipolar show fasciculated dendrites. Sequence=AAH96527.1; Type=Erroneous initiation; Evidence=; plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules negative regulation of cell adhesion nervous system development axon guidance central nervous system development brain development cell surface membrane integral component of membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction axon protein homodimerization activity synapse embryonic skeletal system morphogenesis dendrite self-avoidance protein binding involved in cell-cell adhesion uc009pfz.1 uc009pfz.2 uc009pfz.3 
ENSMUST00000034594.16 Il10ra ENSMUST00000034594.16 interleukin 10 receptor, alpha, transcript variant 1 (from RefSeq NM_008348.3) ENSMUST00000034594.1 ENSMUST00000034594.10 ENSMUST00000034594.11 ENSMUST00000034594.12 ENSMUST00000034594.13 ENSMUST00000034594.14 ENSMUST00000034594.15 ENSMUST00000034594.2 ENSMUST00000034594.3 ENSMUST00000034594.4 ENSMUST00000034594.5 ENSMUST00000034594.6 ENSMUST00000034594.7 ENSMUST00000034594.8 ENSMUST00000034594.9 I10R1_MOUSE Il10r NM_008348 Q61727 uc009pfn.1 uc009pfn.2 uc009pfn.3 Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3 (PubMed:8910398). Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (By similarity). Interacts with IL10. Interacts with IL10RB. Interacts (via its cytoplasmic domain) with JAK1 (via N-terminus). Interacts with BTRC; this interaction leads to IL10RA ubiquitination and subsequent degradation (By similarity). Interacts with STAT3 (PubMed:8910398). Cell membrane ; Single-pass type I membrane protein Cytoplasm Phosphorylated. Phosphorylation of the cytoplasmic tail induced STAT3 activation. Ubiquitinated by BTRC; ubiquitination leads to endocytosis and subsequent degradation of IL10RA. Belongs to the type II cytokine receptor family. cytokine receptor activity interleukin-10 receptor activity cytoplasm plasma membrane negative regulation of autophagy membrane integral component of membrane cytokine-mediated signaling pathway interleukin-10 binding response to lipopolysaccharide positive regulation of JAK-STAT cascade regulation of synapse organization ubiquitin-dependent endocytosis uc009pfn.1 uc009pfn.2 uc009pfn.3 
ENSMUST00000034597.8 Tmprss13 ENSMUST00000034597.8 transmembrane protease, serine 13 (from RefSeq NM_001013373.2) E9QPR6 E9QPR6_MOUSE ENSMUST00000034597.1 ENSMUST00000034597.2 ENSMUST00000034597.3 ENSMUST00000034597.4 ENSMUST00000034597.5 ENSMUST00000034597.6 ENSMUST00000034597.7 NM_001013373 Tmprss13 uc009pfr.1 uc009pfr.2 uc009pfr.3 Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase activity scavenger receptor activity proteolysis endocytosis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc009pfr.1 uc009pfr.2 uc009pfr.3 
ENSMUST00000034599.15 Tmprss4 ENSMUST00000034599.15 transmembrane protease, serine 4, transcript variant 1 (from RefSeq NM_145403.3) Cap2 ENSMUST00000034599.1 ENSMUST00000034599.10 ENSMUST00000034599.11 ENSMUST00000034599.12 ENSMUST00000034599.13 ENSMUST00000034599.14 ENSMUST00000034599.2 ENSMUST00000034599.3 ENSMUST00000034599.4 ENSMUST00000034599.5 ENSMUST00000034599.6 ENSMUST00000034599.7 ENSMUST00000034599.8 ENSMUST00000034599.9 NM_145403 Q8VCA5 TMPS4_MOUSE Tmprss4 uc009pfi.1 uc009pfi.2 uc009pfi.3 Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (By similarity). Seems to be capable of activating ENaC (PubMed:12149280). Cell membrane ; Single-pass type II membrane protein [Transmembrane protease serine 4 catalytic chain]: Secreted Note=Activated by cleavage and secreted. Proteolytically processed; probably by an autocatalytic mechanism. Belongs to the peptidase S1 family. serine-type endopeptidase activity scavenger receptor activity proteolysis endocytosis peptidase activity serine-type peptidase activity response to wounding regulation of gene expression membrane integral component of membrane hydrolase activity secretory granule negative regulation of growth rate uc009pfi.1 uc009pfi.2 uc009pfi.3 
ENSMUST00000034600.5 Mpzl2 ENSMUST00000034600.5 myelin protein zero-like 2, transcript variant 1 (from RefSeq NM_007962.4) ENSMUST00000034600.1 ENSMUST00000034600.2 ENSMUST00000034600.3 ENSMUST00000034600.4 Eva1 F6RG10 F6RG10_MOUSE Mpzl2 NM_007962 uc009pfa.1 uc009pfa.2 uc009pfa.3 uc009pfa.4 membrane integral component of membrane cell-cell adhesion uc009pfa.1 uc009pfa.2 uc009pfa.3 uc009pfa.4 
ENSMUST00000034602.9 Cd3d ENSMUST00000034602.9 CD3 antigen, delta polypeptide (from RefSeq NM_013487.3) CD3d Cd3d ENSMUST00000034602.1 ENSMUST00000034602.2 ENSMUST00000034602.3 ENSMUST00000034602.4 ENSMUST00000034602.5 ENSMUST00000034602.6 ENSMUST00000034602.7 ENSMUST00000034602.8 NM_013487 Q3U4T1 Q3U4T1_MOUSE uc009pey.1 uc009pey.2 uc009pey.3 uc009pey.4 transcription coactivator activity transmembrane signaling receptor activity cell surface receptor signaling pathway membrane integral component of membrane T cell differentiation T cell receptor complex protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein homooligomerization uc009pey.1 uc009pey.2 uc009pey.3 uc009pey.4 
ENSMUST00000034607.10 Arcn1 ENSMUST00000034607.10 archain 1 (from RefSeq NM_145985.4) COPD_MOUSE Copd ENSMUST00000034607.1 ENSMUST00000034607.2 ENSMUST00000034607.3 ENSMUST00000034607.4 ENSMUST00000034607.5 ENSMUST00000034607.6 ENSMUST00000034607.7 ENSMUST00000034607.8 ENSMUST00000034607.9 NM_145985 Q5XJY5 Q91W48 uc009pei.1 uc009pei.2 uc009pei.3 uc009pei.4 uc009pei.5 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily. Golgi membrane cytoplasm endoplasmic reticulum Golgi apparatus cytosol ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER adult locomotory behavior protein transport membrane vesicle-mediated transport cerebellar Purkinje cell layer maturation COPI vesicle coat COPI-coated vesicle COPI-coated vesicle membrane cytoplasmic vesicle pigmentation Golgi vesicle transport Golgi localization uc009pei.1 uc009pei.2 uc009pei.3 uc009pei.4 uc009pei.5 
ENSMUST00000034609.11 Treh ENSMUST00000034609.11 trehalase (brush-border membrane glycoprotein), transcript variant 1 (from RefSeq NM_021481.3) ENSMUST00000034609.1 ENSMUST00000034609.10 ENSMUST00000034609.2 ENSMUST00000034609.3 ENSMUST00000034609.4 ENSMUST00000034609.5 ENSMUST00000034609.6 ENSMUST00000034609.7 ENSMUST00000034609.8 ENSMUST00000034609.9 NM_021481 Q91ZS4 Q9JLT2 TREA_MOUSE Treh uc009pec.1 uc009pec.2 uc009pec.3 This gene belongs to the alpha-glucosidase family, whose members encode enzymes that carry out hydrolysis of alpha-glucoside bonds of a variety of carbohydrates. The enzyme encoded by this gene uses the disaccharide trehalose as a highly specific substrate and converts it into two glucose molecules. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]. Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose. Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D- glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903, ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28; Evidence=; Homodimer; disulfide-linked. Cell membrane ; Lipid-anchor, GPI-anchor Belongs to the glycosyl hydrolase 37 family. catalytic activity alpha,alpha-trehalase activity plasma membrane brush border trehalose metabolic process trehalose catabolic process metabolic process animal organ morphogenesis membrane hydrolase activity hydrolase activity, acting on glycosyl bonds anchored component of membrane uc009pec.1 uc009pec.2 uc009pec.3 
ENSMUST00000034610.4 Pate4 ENSMUST00000034610.4 prostate and testis expressed 4 (from RefSeq NM_020264.5) ENSMUST00000034610.1 ENSMUST00000034610.2 ENSMUST00000034610.3 NM_020264 PATE4_MOUSE Q09098 Q9D248 Q9R018 Svs7 uc009otk.1 uc009otk.2 uc009otk.3 uc009otk.4 Enhances sperm motility. Binds to calmodulin and inhibits calcium transport into spermatozoa. May modulate the function of nicotinic acetylcholine receptors. Secreted. Expressed in prostate, testis, eye, kidney and skeletal muscle. Expressed in the dorsal lobe of prostate. Not expressed in the ventral lobe of prostate. By castration in the ventral lobe of prostate. This induction is suppressed by subsequent dihydroxytestosterone administration. Mass=8538.0; Method=Electrospray; Evidence=; Belongs to the PATE family. acrosomal vesicle calmodulin binding extracellular region extracellular space response to wounding modulation of synaptic transmission uc009otk.1 uc009otk.2 uc009otk.3 uc009otk.4 
ENSMUST00000034612.7 Ddx25 ENSMUST00000034612.7 DEAD box helicase 25 (from RefSeq NM_013932.4) DDX25_MOUSE ENSMUST00000034612.1 ENSMUST00000034612.2 ENSMUST00000034612.3 ENSMUST00000034612.4 ENSMUST00000034612.5 ENSMUST00000034612.6 Grth NM_013932 Q53Z03 Q7TMB5 Q8R1B6 Q9QY15 uc012gqi.1 uc012gqi.2 uc012gqi.3 ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Cytoplasm cleus te=Detected in both cytoplasm and nucleus of testicular cells. Also detected in chromatoid bodies of round spermatids. Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=Q9QY15-1; Sequence=Displayed; Name=2; IsoId=Q9QY15-2; Sequence=VSP_018876; Isoform 1 is expressed in germ cells. Isoform 2 is expressed in Leydig cells and in round spermatids of adult testis upon gonadotropin stimulation. Phosphorylated on threonine residues. The phosphorylated form is found in the cytoplasm but not in the nucleus. Male mice display normal sexual behavior but are sterile with testes that are 25% smaller than the wild-type. Round spermatids arrest at step 8 and fail to elongate. Chromatoid bodies are unusually condensed, greatly reduced in size and lack the typical amorphous texture throughout all steps of spermiogenesis. Belongs to the DEAD box helicase family. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus cytoplasm mRNA export from nucleus regulation of translation multicellular organism development spermatogenesis spermatid development cytoplasmic stress granule hydrolase activity ATPase activity poly(A)+ mRNA export from nucleus cell differentiation chromatoid body mRNA transport uc012gqi.1 uc012gqi.2 uc012gqi.3 
ENSMUST00000034615.10 Pus3 ENSMUST00000034615.10 pseudouridine synthase 3 (from RefSeq NM_023292.5) ENSMUST00000034615.1 ENSMUST00000034615.2 ENSMUST00000034615.3 ENSMUST00000034615.4 ENSMUST00000034615.5 ENSMUST00000034615.6 ENSMUST00000034615.7 ENSMUST00000034615.8 ENSMUST00000034615.9 NM_023292 PUS3_MOUSE Q8BVA6 Q8K0Y3 Q9JI38 uc009oth.1 uc009oth.2 uc009oth.3 uc009oth.4 Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs. Also acts on position 38, but much less efficiently. Reaction=uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA; Xref=Rhea:RHEA:42564, Rhea:RHEA-COMP:10117, Rhea:RHEA-COMP:10118, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.45; Evidence=; Nucleus Belongs to the tRNA pseudouridine synthase TruA family. pseudouridine synthesis RNA binding nucleus cytoplasm tRNA processing RNA modification pseudouridine synthase activity isomerase activity tRNA pseudouridine synthesis mRNA pseudouridine synthesis uc009oth.1 uc009oth.2 uc009oth.3 uc009oth.4 
ENSMUST00000034618.6 Nherf4 ENSMUST00000034618.6 NHERF family PDZ scaffold protein 4 (from RefSeq NM_133226.2) A0A0R4J0D4 A0A0R4J0D4_MOUSE ENSMUST00000034618.1 ENSMUST00000034618.2 ENSMUST00000034618.3 ENSMUST00000034618.4 ENSMUST00000034618.5 NM_133226 Nherf4 Pdzd3 uc009pch.1 uc009pch.2 uc009pch.3 brush border ion transport receptor guanylyl cyclase signaling pathway protein C-terminus binding negative regulation of cGMP-mediated signaling guanylate cyclase inhibitor activity negative regulation of guanylate cyclase activity subapical complex apical part of cell ubiquitin-specific protease binding uc009pch.1 uc009pch.2 uc009pch.3 
ENSMUST00000034619.2 Pate6 ENSMUST00000034619.2 prostate and testis expressed 6 (from RefSeq NM_026593.3) D730048I06Rik ENSMUST00000034619.1 NM_026593 Pate6 Q9CQB8 Q9CQB8_MOUSE uc009otn.1 uc009otn.2 uc009otn.1 uc009otn.2 
ENSMUST00000034620.5 Acrv1 ENSMUST00000034620.5 acrosomal vesicle protein 1, transcript variant 1 (from RefSeq NM_007391.4) ASPX_MOUSE B2RT20 ENSMUST00000034620.1 ENSMUST00000034620.2 ENSMUST00000034620.3 ENSMUST00000034620.4 NM_007391 P50289 Q9DAM6 uc009otu.1 uc009otu.2 uc009otu.3 Testis. The N-terminus is blocked. acrosomal vesicle uc009otu.1 uc009otu.2 uc009otu.3 
ENSMUST00000034623.8 Trappc4 ENSMUST00000034623.8 trafficking protein particle complex 4, transcript variant 1 (from RefSeq NM_021789.3) ENSMUST00000034623.1 ENSMUST00000034623.2 ENSMUST00000034623.3 ENSMUST00000034623.4 ENSMUST00000034623.5 ENSMUST00000034623.6 ENSMUST00000034623.7 NM_021789 Q9DB31 Q9ES56 Sbdn TPPC4_MOUSE Trappc4 uc009pdk.1 uc009pdk.2 uc009pdk.3 Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (By similarity). May play a role in dendrite postsynaptic membrane trafficking (PubMed:11018053). Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12 (By similarity). Interacts with SDC2 (PubMed:11018053). Postsynaptic cell membrane Golgi apparatus membrane Endoplasmic reticulum Vesicle Note=Associated with postsynaptic membranes and in intracellular cisterns and vesicles (Golgi). Widely expressed. Belongs to the TRAPP small subunits family. TRAPPC4 subfamily. protein binding endoplasmic reticulum Golgi apparatus Golgi stack plasma membrane ER to Golgi vesicle-mediated transport synaptic vesicle membrane vesicle-mediated transport dendrite development Rab guanyl-nucleotide exchange factor activity TRAPP complex cell junction dendrite synapse postsynaptic membrane neurotransmitter receptor biosynthetic process uc009pdk.1 uc009pdk.2 uc009pdk.3 
ENSMUST00000034625.12 Chek1 ENSMUST00000034625.12 checkpoint kinase 1, transcript variant 1 (from RefSeq NM_007691.6) CHK1_MOUSE Chk1 ENSMUST00000034625.1 ENSMUST00000034625.10 ENSMUST00000034625.11 ENSMUST00000034625.2 ENSMUST00000034625.3 ENSMUST00000034625.4 ENSMUST00000034625.5 ENSMUST00000034625.6 ENSMUST00000034625.7 ENSMUST00000034625.8 ENSMUST00000034625.9 NM_007691 O35280 O54925 Q8CI40 Q9D0N2 uc009otw.1 uc009otw.2 uc009otw.3 Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:10859163, PubMed:10859164, PubMed:15261141). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:10859163, PubMed:10859164, PubMed:15261141). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:10859163, PubMed:10859164, PubMed:15261141). Recognizes the substrate consensus sequence [R-X-X- S/T] (PubMed:10859163, PubMed:10859164, PubMed:15261141). Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA (By similarity). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones. Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (PubMed:18243098). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest. Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (By similarity). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Activated through phosphorylation predominantly by ATR but also by ATM in response to DNA damage or inhibition of DNA replication. Activation is modulated by several mediators including CLSPN, BRCA1 and FEM1B. Proteolytic cleavage at the C-terminus by SPRTN during normal DNA replication activates the protein kinase activity. Interacts (phosphorylated by ATR) with RAD51 (By similarity). Interacts with and phosphorylates CLSPN, an adapter protein that regulates the ATR-dependent phosphorylation of CHEK1 (By similarity). Interacts with BRCA1 (By similarity). Interacts with and phosphorylates CDC25A, CDC25B and CDC25C (By similarity). Interacts with FBXO6, which regulates CHEK1 (By similarity). Interacts with PPM1D, which regulates CHEK1 through dephosphorylation (By similarity). Interacts with TIMELESS; DNA damage-dependent (PubMed:23418588). Interacts with FEM1B; activates CHEK1 in response to stress (By similarity). Interacts with TLK1 (By similarity). Interacts with XPO1 and YWHAZ (By similarity). Interacts with CDK5RAP3; antagonizes CHEK1 (By similarity). Nucleus romosome toplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Nuclear export is mediated at least in part by XPO1/CRM1. Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B. Proteolytic cleavage at the C-terminus by SPRTN promotes removal from chromatin. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O35280-1; Sequence=Displayed; Name=2; IsoId=O35280-2; Sequence=VSP_015791, VSP_015792; Found in all adult tissues tested. Elevated expression in testis, lung and spleen. 15.5 day old embryos show ubiquitous expression with strong expression in brain, liver, kidney, pancreas, intestine, thymus and lung. In the testis, present in cells undergoing meiosis I. Not detected in peripheral cells in seminiferous tubules that are undergoing pre-meiotic DNA synthesis or in late condensing or mature sperm. The autoinhibitory region (AIR) inhibits the activity of the kinase domain. Phosphorylated by ATR in a RAD17-dependent manner in response to ultraviolet irradiation and inhibition of DNA replication. Phosphorylated by ATM in response to ionizing irradiation. ATM and ATR can both phosphorylate Ser-317 and Ser-345 and this results in enhanced kinase activity. Phosphorylation at Ser-345 induces a change in the conformation of the protein, activates the kinase activity and is a prerequisite for interaction with FBXO6 and subsequent ubiquitination at Lys-436. Phosphorylation at Ser-345 also increases binding to 14-3-3 proteins and promotes nuclear retention. Conversely, dephosphorylation at Ser-345 by PPM1D may contribute to exit from checkpoint mediated cell cycle arrest. Phosphorylation at Ser-280 by AKT1/PKB, may promote mono and/or diubiquitination. Also phosphorylated at undefined residues during mitotic arrest, resulting in decreased activity. Ubiquitinated (PubMed:15710331). Mono or diubiquitination promotes nuclear exclusion (PubMed:15710331). The activated form (phosphorylated on Ser-345) is polyubiquitinated at Lys-436 by some SCF-type E3 ubiquitin ligase complex containing FBXO6 promoting its degradation (By similarity). Ubiquitination and degradation are required to terminate the checkpoint and ensure that activated CHEK1 does not accumulate as cells progress through S phase, when replication forks encounter transient impediments during normal DNA replication. 'Lys-63'-mediated ubiquitination by TRAF4 at Lys-132 activates cell cycle arrest and activation of DNA repair (By similarity). Proteolytically cleaved at the C-terminus by SPRTN during normal DNA replication, thereby promoting CHEK1 removal from chromatin and activating the protein kinase activity. Mice die of apoptosis at the blastocyst stage. Haploinsufficient for the suppression of genomic instability and tumor progression. [Isoform 2]: 3 initiator methionines can be considered. If this isoform were to start at the first ATG, it would produce a 28 amino acid-long peptide, sharing the first 22 amino acids with the canonical sequence (isoform 1) and differing in the last 6 residues (VQLAVN -> ARHRDA). An initiation at this site could target the mRNA to nonsense-mediated mRNA decay and, in this case, the peptide would be produced at very low levels. The second possible translation initiation site would lead to the synthesis of the sequence shown in this entry as isoform 2. However, the Kozak sequence for this site is not optimal. Finally the third potential initiator methionine corresponds to position 167 in isoform 1 and would lead to the synthesis of a 310 amino acid-long protein identical to isoform 1 residues 167 through 476. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. Sequence=AAH37613.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; DNA damage checkpoint G2/M transition of mitotic cell cycle nucleotide binding chromatin condensed nuclear chromosome inner cell mass cell proliferation protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm replication fork cytoplasm centrosome microtubule organizing center cytoskeleton DNA repair protein phosphorylation apoptotic process cellular response to DNA damage stimulus DNA damage induced protein phosphorylation nucleus organization cell cycle mitotic cell cycle checkpoint regulation of gene expression regulation of double-strand break repair via homologous recombination regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage negative regulation of G2/M transition of mitotic cell cycle kinase activity phosphorylation transferase activity peptidyl-threonine phosphorylation protein domain specific binding macromolecular complex histone kinase activity (H3-T11 specific) histone H3-T11 phosphorylation intracellular signal transduction regulation of cell proliferation intracellular membrane-bounded organelle positive regulation of cell cycle negative regulation of mitotic nuclear division regulation of mitotic centrosome separation chromatin-mediated maintenance of transcription signal transduction involved in G2 DNA damage checkpoint apoptotic process involved in development negative regulation of DNA biosynthetic process regulation of histone H3-K9 acetylation chromosome, telomeric region uc009otw.1 uc009otw.2 uc009otw.3 
ENSMUST00000034630.15 Fez1 ENSMUST00000034630.15 fasciculation and elongation protein zeta 1, transcript variant 4 (from RefSeq NM_183171.6) ENSMUST00000034630.1 ENSMUST00000034630.10 ENSMUST00000034630.11 ENSMUST00000034630.12 ENSMUST00000034630.13 ENSMUST00000034630.14 ENSMUST00000034630.2 ENSMUST00000034630.3 ENSMUST00000034630.4 ENSMUST00000034630.5 ENSMUST00000034630.6 ENSMUST00000034630.7 ENSMUST00000034630.8 ENSMUST00000034630.9 FEZ1_MOUSE NM_183171 Q3YE74 Q8K0X8 uc009ouc.1 uc009ouc.2 uc009ouc.3 May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules (By similarity). Homodimer. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon. Interacts with UBE4B and SAP30L (By similarity). Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1 (By similarity). Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cell membrane Note=Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination. Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26 (By similarity). Belongs to the zygin family. protein kinase C binding protein binding cytoplasm mitochondrion Golgi apparatus centrosome microtubule organizing center cytoskeleton microtubule plasma membrane positive regulation of neuron projection development membrane hippocampus development establishment of cell polarity axon dendrite growth cone cell projection gamma-tubulin binding neuronal cell body positive regulation of neuron differentiation protein N-terminus binding establishment of mitochondrion localization mitochondrion morphogenesis cellular response to growth factor stimulus negative regulation of autophagosome assembly uc009ouc.1 uc009ouc.2 uc009ouc.3 
ENSMUST00000034632.10 Tmem218 ENSMUST00000034632.10 transmembrane protein 218, transcript variant 2 (from RefSeq NM_025464.3) ENSMUST00000034632.1 ENSMUST00000034632.2 ENSMUST00000034632.3 ENSMUST00000034632.4 ENSMUST00000034632.5 ENSMUST00000034632.6 ENSMUST00000034632.7 ENSMUST00000034632.8 ENSMUST00000034632.9 NM_025464 Q8CF13 Q9CQ44 TM218_MOUSE uc009ouj.1 uc009ouj.2 uc009ouj.3 uc009ouj.4 May be involved in ciliary biogenesis or function. Interacts with TMEM67. Membrane ; Multi-pass membrane protein Cell projection, cilium Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Diffuse renal cyst development with tubulointerstitial nephropathy and disruption of tubular basement membranes in essentially normal-sized kidneys. Retinal lesions characterized by slow-onset loss of photoreceptors. Belongs to the TMEM218 family. molecular_function cellular_component cilium biological_process membrane integral component of membrane cell projection uc009ouj.1 uc009ouj.2 uc009ouj.3 uc009ouj.4 
ENSMUST00000034643.12 Robo3 ENSMUST00000034643.12 Robo3 (from geneSymbol) AF060570 E9QPQ1 E9QPQ1_MOUSE ENSMUST00000034643.1 ENSMUST00000034643.10 ENSMUST00000034643.11 ENSMUST00000034643.2 ENSMUST00000034643.3 ENSMUST00000034643.4 ENSMUST00000034643.5 ENSMUST00000034643.6 ENSMUST00000034643.7 ENSMUST00000034643.8 ENSMUST00000034643.9 Robo3 uc292fuz.1 uc292fuz.2 axon guidance uc292fuz.1 uc292fuz.2 
ENSMUST00000034644.10 Vps11 ENSMUST00000034644.10 VPS11, CORVET/HOPS core subunit, transcript variant 1 (from RefSeq NM_027889.2) ENSMUST00000034644.1 ENSMUST00000034644.2 ENSMUST00000034644.3 ENSMUST00000034644.4 ENSMUST00000034644.5 ENSMUST00000034644.6 ENSMUST00000034644.7 ENSMUST00000034644.8 ENSMUST00000034644.9 NM_027889 Q5FWZ1 Q91W86 Q9DBX8 VPS11_MOUSE uc033jka.1 uc033jka.2 uc033jka.3 Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (By similarity). Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, which in HOPS further associates with VPS39 and VPS41 and in CORVET with VPS8 and TGFBRAP1 (PubMed:25266290). Interacts with RAB5C (PubMed:25266290). Interacts with TGFBRAP1, MON1B, STX7, STX17, ECPAS, EZR, RDX, MSN (By similarity). Associates with adaptor protein complex 3 (AP-3) and clathrin:AP-3 complexes (PubMed:21411634). Interacts with PLEKHM1 (By similarity). Q91W86; Q9H9C1: VIPAS39; Xeno; NbExp=3; IntAct=EBI-2527812, EBI-749080; Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle Early endosome Cytoplasmic vesicle, autophagosome Cytoplasmic vesicle, clathrin-coated vesicle Belongs to the VPS11 family. nucleotide binding protein binding lysosome lysosomal membrane endosome early endosome late endosome autophagosome actin filament intracellular protein transport vesicle docking involved in exocytosis autophagy endosome organization vacuole organization endosome to lysosome transport protein transport membrane vesicle-mediated transport protein domain specific binding syntaxin binding clathrin-coated vesicle endocytic vesicle protein binding, bridging HOPS complex cytoplasmic vesicle late endosome membrane CORVET complex endosomal vesicle fusion regulation of SNARE complex assembly metal ion binding presynaptic active zone toxin transport regulation of organelle assembly positive regulation of cellular protein catabolic process positive regulation of early endosome to late endosome transport AP-3 adaptor complex uc033jka.1 uc033jka.2 uc033jka.3 
ENSMUST00000034647.11 Zfp558 ENSMUST00000034647.11 zinc finger protein 558, transcript variant 1 (from RefSeq NM_028935.1) E9Q1J0 E9Q1J0_MOUSE ENSMUST00000034647.1 ENSMUST00000034647.10 ENSMUST00000034647.2 ENSMUST00000034647.3 ENSMUST00000034647.4 ENSMUST00000034647.5 ENSMUST00000034647.6 ENSMUST00000034647.7 ENSMUST00000034647.8 ENSMUST00000034647.9 NM_028935 Zfp558 uc012gor.1 uc012gor.2 uc012gor.3 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc012gor.1 uc012gor.2 uc012gor.3 
ENSMUST00000034650.15 Mcam ENSMUST00000034650.15 melanoma cell adhesion molecule, transcript variant 1 (from RefSeq NM_023061.3) ENSMUST00000034650.1 ENSMUST00000034650.10 ENSMUST00000034650.11 ENSMUST00000034650.12 ENSMUST00000034650.13 ENSMUST00000034650.14 ENSMUST00000034650.2 ENSMUST00000034650.3 ENSMUST00000034650.4 ENSMUST00000034650.5 ENSMUST00000034650.6 ENSMUST00000034650.7 ENSMUST00000034650.8 ENSMUST00000034650.9 MUC18_MOUSE Muc18 NM_023061 Q8R2Y2 Q9EPF1 Q9ESS7 Q9JHQ2 Q9JHQ3 uc009pbw.1 uc009pbw.2 uc009pbw.3 uc009pbw.4 Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity). Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=L-gicerin; IsoId=Q8R2Y2-1; Sequence=Displayed; Name=2; Synonyms=S-gicerin; IsoId=Q8R2Y2-2; Sequence=VSP_016940; Detected in melanoma cell lines. angiogenesis glomerular filtration extracellular space nucleus plasma membrane cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules external side of plasma membrane membrane integral component of membrane positive regulation of cell migration vascular wound healing uc009pbw.1 uc009pbw.2 uc009pbw.3 uc009pbw.4 
ENSMUST00000034654.9 Mfrp ENSMUST00000034654.9 membrane frizzled-related protein, transcript variant 1 (from RefSeq NM_147126.3) ENSMUST00000034654.1 ENSMUST00000034654.2 ENSMUST00000034654.3 ENSMUST00000034654.4 ENSMUST00000034654.5 ENSMUST00000034654.6 ENSMUST00000034654.7 ENSMUST00000034654.8 MFRP_MOUSE NM_147126 Q8BPP4 Q8K480 uc009pbr.1 uc009pbr.2 uc009pbr.3 uc009pbr.4 The protein encoded by this gene contains a region with similarity to the cysteine-rich domain (CRD) of frizzled, a gene originally found in Drosophila that controls tissue polarity. This protein functions in eye development, where it is necessary for the maintenance of photoreceptor outer segments. Mutations in this gene cause retinal degeneration 6 in mice, which gives rise to a mouse model for human retinitis punctata albescens. Bicistronic transcripts composed of the coding sequences for this gene (Mfrp) and the C1q and tumor necrosis factor related protein 5 gene (C1qtnf5) have been identified, and the resulting products can interact with each other. Co-transcription of C1qtnf5 and Mfrp has been observed in both human and mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]. May play a role in eye development. Interacts with C1QTNF5. Q8K480; Q8K479: C1qtnf5; NbExp=5; IntAct=EBI-29374967, EBI-29374993; Apical cell membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K480-1; Sequence=Displayed; Name=2; IsoId=Q8K480-2; Sequence=VSP_017664; Expressed in retinal pigment epithelium and ciliary epithelium of the eye. Note=Defects in Mfrp are the cause of retinal degeneration 6 (RD6). RD6 is an autosomal recessive degeneration of the photoreceptors causing dysfunction of both rods and cones. plasma membrane visual perception membrane integral component of membrane apical plasma membrane eye photoreceptor cell development retina development in camera-type eye uc009pbr.1 uc009pbr.2 uc009pbr.3 uc009pbr.4 
ENSMUST00000034689.8 Pin1 ENSMUST00000034689.8 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1, transcript variant 1 (from RefSeq NM_023371.4) ENSMUST00000034689.1 ENSMUST00000034689.2 ENSMUST00000034689.3 ENSMUST00000034689.4 ENSMUST00000034689.5 ENSMUST00000034689.6 ENSMUST00000034689.7 NM_023371 PIN1_MOUSE Q543B3 Q9QUR7 uc009ojd.1 uc009ojd.2 uc009ojd.3 Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis- promoting activity. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (By similarity). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (By similarity). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin- protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8- mediated homologous recombination (HR) (By similarity). Upon IL33- induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Interacts with STIL (PubMed:16024801). Interacts with KIF20B. Interacts with NEK6. Interacts (via WW domain) with PRKX (PubMed:19367327). Interacts with BTK. Interacts (via PpiC domain) with DAPK1. Interacts with the phosphorylated form of RAF1. Interacts (via WW domain) with ATCAY; upon NGF stimulation. Interacts with PML. Interacts with BCL6. Interacts with FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation (By similarity). Directly interacts with RBBP8/CtIP; this interaction depends upon RBBP8 phosphorylation (By similarity). Interacts (via WW domain) with IRAK3/IRAK-M (when phosphorylated at 'Ser-110') in response to IL33-mediated (but not TLR4 ligand LPS) dendritic cell stimulation (PubMed:29686383). Q9QUR7; Q8BUV3: Gphn; NbExp=6; IntAct=EBI-2432975, EBI-771218; Q9QUR7; Q80Z64: Nanog; NbExp=2; IntAct=EBI-2432975, EBI-2312517; Q9QUR7; P02340: Tp53; NbExp=3; IntAct=EBI-2432975, EBI-474016; Nucleus Nucleus speckle Cytoplasm Note=Colocalizes with NEK6 in the nucleus. Mainly localized in the nucleus but phosphorylation at Ser-73 by DAPK1 results in inhibition of its nuclear localization. Expressed in dendritic cells (at protein level). The WW domain is required for the interaction with STIL and KIF20B. Phosphorylation at Ser-73 by DAPK1 results in inhibition of its catalytic activity, nuclear localization, and its ability to induce centrosome amplification, chromosome instability and cell transformation (By similarity). Ser-73 is dephosphorylated upon IL33- stimulation of dendritic cells (PubMed:29686383). Animals display more and larger germinal centers (PubMed:17828269). In response to intranasal administration of IL33, lung inflammation is reduced compared to wild-type and is associated with low infiltration by inflammatory cells, especially granulocytes, a severe reduction in Th2-type cytokine secretion, including Il4, Il5 and Il13 in bronchial alveolar fluids, and reduced up-regulation of Il6, Csf3, Cxcl2 and Ccl5 mRNAs (PubMed:29686383). In addition, the increase in IRAK3/IRAK-M protein levels in infiltrated inflammatory cells is impaired (PubMed:29686383). In an ovalbumin-induced model of allergic asthma, causes reduced lung inflammation and, reduced Th2-type cytokine levels and inflammatory cell infiltration in bronchial alveolar fluids (PubMed:29686383). protein peptidyl-prolyl isomerization response to hypoxia regulation of protein phosphorylation positive regulation of protein phosphorylation peptidyl-prolyl cis-trans isomerase activity motor activity protein binding nucleus nucleoplasm cytoplasm mitochondrion cytosol cell cycle beta-catenin binding regulation of gene expression nuclear speck isomerase activity cis-trans isomerase activity neuron differentiation midbody negative regulation of transforming growth factor beta receptor signaling pathway mitogen-activated protein kinase kinase binding regulation of protein stability negative regulation of protein binding positive regulation of protein binding regulation of cytokinesis GTPase activating protein binding positive regulation of protein dephosphorylation regulation of cell proliferation negative regulation of protein catabolic process neuron projection negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of transcription from RNA polymerase II promoter synapse organization phosphoserine binding phosphothreonine binding protein stabilization phosphoprotein binding positive regulation of ubiquitin-protein transferase activity regulation of pathway-restricted SMAD protein phosphorylation positive regulation of cell growth involved in cardiac muscle cell development negative regulation of ERK1 and ERK2 cascade positive regulation of canonical Wnt signaling pathway glutamatergic synapse postsynaptic cytosol regulation of protein localization to nucleus negative regulation of beta-amyloid formation negative regulation of cell motility uc009ojd.1 uc009ojd.2 uc009ojd.3 
ENSMUST00000034698.9 Tmed1 ENSMUST00000034698.9 transmembrane p24 trafficking protein 1, transcript variant 1 (from RefSeq NM_010744.4) ENSMUST00000034698.1 ENSMUST00000034698.2 ENSMUST00000034698.3 ENSMUST00000034698.4 ENSMUST00000034698.5 ENSMUST00000034698.6 ENSMUST00000034698.7 ENSMUST00000034698.8 Il1rl1l NM_010744 Q3TUX8 Q3V009 Q61073 Q91YK3 TMED1_MOUSE uc009olp.1 uc009olp.2 uc009olp.3 uc009olp.4 Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1. Plays also a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. Homodimer in endoplasmic reticulum, endoplasmic reticulum- Golgi intermediate compartment and cis-Golgi network. Interacts with IL1RL1. Interacts with RNF26; this interaction is important to modulate innate immune signaling through the cGAS-STING pathway. Cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Golgi apparatus, cis-Golgi network membrane ; Single-pass type I membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3V009-1; Sequence=Displayed; Name=2; IsoId=Q3V009-2; Sequence=VSP_020135, VSP_020136; Widely expressed. Belongs to the EMP24/GP25L family. endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus plasma membrane intracellular protein transport ER to Golgi vesicle-mediated transport Golgi organization protein transport membrane integral component of membrane ER to Golgi transport vesicle endoplasmic reticulum-Golgi intermediate compartment membrane uc009olp.1 uc009olp.2 uc009olp.3 uc009olp.4 
ENSMUST00000034699.8 Scg3 ENSMUST00000034699.8 secretogranin III, transcript variant 1 (from RefSeq NM_009130.3) ENSMUST00000034699.1 ENSMUST00000034699.2 ENSMUST00000034699.3 ENSMUST00000034699.4 ENSMUST00000034699.5 ENSMUST00000034699.6 ENSMUST00000034699.7 NM_009130 P47867 Q3UTT1 Q3UZT8 Q8R1D7 SCG3_MOUSE uc009qss.1 uc009qss.2 uc009qss.3 uc009qss.4 Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:16219686). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (PubMed:12388744). May also play a role in angiogenesis (PubMed:28330905). Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity). Interacts with CHGA (PubMed:12388744). Interacts with secretogranin II/SCG2 (By similarity). Interacts (via C-terminus) with CPE (PubMed:16219686). Cytoplasmic vesicle, secretory vesicle Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein Secreted Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P47867-1; Sequence=Displayed; Name=2; IsoId=P47867-2; Sequence=VSP_042877; Expressed in various brain areas, with highest levels in the arcuate nucleus and the lateral hypothalamic area, as well as the paraventricular nucleus and the ventromedial hypothalamus (at protein level). protein binding extracellular region membrane transport vesicle transport vesicle membrane secretory granule membrane cytoplasmic vesicle protein localization to secretory granule uc009qss.1 uc009qss.2 uc009qss.3 uc009qss.4 
ENSMUST00000034700.15 Yipf2 ENSMUST00000034700.15 Yip1 domain family, member 2, transcript variant 1 (from RefSeq NM_138303.2) ENSMUST00000034700.1 ENSMUST00000034700.10 ENSMUST00000034700.11 ENSMUST00000034700.12 ENSMUST00000034700.13 ENSMUST00000034700.14 ENSMUST00000034700.2 ENSMUST00000034700.3 ENSMUST00000034700.4 ENSMUST00000034700.5 ENSMUST00000034700.6 ENSMUST00000034700.7 ENSMUST00000034700.8 ENSMUST00000034700.9 NM_138303 Q99LF3 Q99LP8 YIPF2_MOUSE uc009olx.1 uc009olx.2 uc009olx.3 uc009olx.4 Interacts with YIPF6; this interaction may stabilize YIPF2. May also form a ternary complex with YIPF1 and YIPF6. Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane Late endosome membrane Note=Mainly localizes within medial-/trans-Golgi and trans-Golgi network (TGN), while less so within cis-Golgi. Belongs to the YIP1 family. Golgi trans cisterna endosome Golgi apparatus Golgi medial cisterna trans-Golgi network biological_process membrane integral component of membrane vesicle-mediated transport Rab GTPase binding transport vesicle late endosome membrane uc009olx.1 uc009olx.2 uc009olx.3 uc009olx.4 
ENSMUST00000034702.6 Lysmd2 ENSMUST00000034702.6 LysM, putative peptidoglycan-binding, domain containing 2 (from RefSeq NM_027309.2) ENSMUST00000034702.1 ENSMUST00000034702.2 ENSMUST00000034702.3 ENSMUST00000034702.4 ENSMUST00000034702.5 G3X915 G3X915_MOUSE Lysmd2 NM_027309 uc009qsq.1 uc009qsq.2 uc009qsq.3 uc009qsq.1 uc009qsq.2 uc009qsq.3 
ENSMUST00000034703.15 Carm1 ENSMUST00000034703.15 coactivator-associated arginine methyltransferase 1, transcript variant 1 (from RefSeq NM_021531.6) CARM1_MOUSE ENSMUST00000034703.1 ENSMUST00000034703.10 ENSMUST00000034703.11 ENSMUST00000034703.12 ENSMUST00000034703.13 ENSMUST00000034703.14 ENSMUST00000034703.2 ENSMUST00000034703.3 ENSMUST00000034703.4 ENSMUST00000034703.5 ENSMUST00000034703.6 ENSMUST00000034703.7 ENSMUST00000034703.8 ENSMUST00000034703.9 NM_021531 Prmt4 Q3TYB9 Q8K1Y5 Q91W24 Q99KX8 Q9WVG6 uc009olu.1 uc009olu.2 uc009olu.3 uc009olu.4 Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability (PubMed:10381882, PubMed:21138967, PubMed:11341840, PubMed:11997499, PubMed:19897492, PubMed:14966289, PubMed:17218272). Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activates transcription via chromatin remodeling (PubMed:10381882, PubMed:11747826, PubMed:12498683, PubMed:11751582, PubMed:11341840, PubMed:11997499, PubMed:15339660, PubMed:15616592). During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription (PubMed:11997499, PubMed:16322096, PubMed:17882261, PubMed:19843527). During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C (PubMed:11713257). During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B (PubMed:11983685). Acts as a coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue (PubMed:18188184). Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors (PubMed:21138967). Also seems to be involved in p53/TP53 transcriptional activation (PubMed:15186775). Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation (PubMed:11701890). Also methylates arginine residues in RNA- binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA- stabilizing properties and the half-life of their target mRNAs (PubMed:11850402, PubMed:12756295, PubMed:12237300). Acts as a transcriptional coactivator of ACACA/acetyl-CoA carboxylase by enriching H3R17 methylation at its promoter, thereby positively regulating fatty acid synthesis (PubMed:30366907). Independently of its methyltransferase activity, involved in replication fork progression: promotes PARP1 recruitment to replication forks, leading to poly-ADP- ribosylation of chromatin at replication forks and reduced fork speed (By similarity). Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA- COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319; Evidence= Methylation of H3R17 (H3R17me) by CARM1 is stimulated by preacetylation of H3 'Lys-18' (H3K18ac) H3 'Lys-23' (H3K23ac) by EP300 and blocked by citrullination of H3 'Arg-17' (H3R17ci) by PADI4. Homodimer (PubMed:17882261, PubMed:19897492). Interacts with NR1H4 (By similarity). Interacts with SNRPC (By similarity). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1 (PubMed:10381882). Part of a complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1 (PubMed:11997499). Interacts with FLII, TP53, myogenic factor MEF2, EP300/P300, TRIM24, CREBBP and CTNNB1 (PubMed:14966289, PubMed:15186775, PubMed:11713257, PubMed:16322096, PubMed:11997499, PubMed:11701890, PubMed:11983685, PubMed:19843527). Interacts with RELA (PubMed:15616592). Identified in a complex containing CARM1, TRIM24 and NCOA2/GRIP1 (PubMed:16322096). Interacts with NCOA3/SRC3 (PubMed:19843527). Interacts with SKP2 (PubMed:30366907). Interacts (via PH domain-like fold) with C9orf72 (PubMed:30366907). Interacts with PARP1; promoting PARP1 recruimtent to replication forks (By similarity). Nucleus toplasm romosome Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane. Localizes to replication forks. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WVG6-1; Sequence=Displayed; Name=2; IsoId=Q9WVG6-2; Sequence=VSP_012508; Ubiquitously expressed. Within the brain, present in proliferating cells from lateral ventricular zone and dentate gyrus (at protein level). At 9 dpc, expression is prominent in the neural tube and somites. Phosphorylation at Ser-217 is strongly increased during mitosis, and decreases rapidly to a very low, basal level after entry into the G1 phase of the cell cycle (By similarity). Phosphorylation at Ser-217 interferes with S-adenosyl-L-methionine binding and strongly reduces methyltransferase activity. Phosphorylation at Ser-217 may promote cytosolic location (PubMed:19843527). Auto-methylated on Arg-551. Methylation enhances transcription coactivator activity. Methylation is required for its role in the regulation of pre-mRNA alternative splicing. Ubiquitinated by E3 ubiquitin-protein ligase complex containing FBXO9 at Lys-228; leading to proteasomal degradation. Neonatal lethality. The lungs of neonates do not inflate and they do not breathe. The same neonate lethality is observed with mutants that produce CARM1 protein without enzyme activity. Embryos are distinctly smaller at 18.5 dpc. They show reduced lipid accumulation in brown adipose tissue and reduced amounts of brown adipose tissue. Thymocyte differentiation is blocked at an early stage. Mutants display complete loss of protein methylation of the CARM1 substrates PABPC1 and EP300/P300. Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. regulation of growth plate cartilage chondrocyte proliferation transcription coactivator activity protein binding nucleus nucleoplasm cytoplasm cytosol chromatin organization regulation of transcription, DNA-templated protein methylation aging methyltransferase activity protein methyltransferase activity positive regulation of cell proliferation histone-arginine N-methyltransferase activity protein-arginine N-methyltransferase activity histone methylation transferase activity peptidyl-arginine methylation, to asymmetrical-dimethyl arginine ligand-dependent nuclear receptor transcription coactivator activity intracellular steroid hormone receptor signaling pathway intracellular estrogen receptor signaling pathway negative regulation of protein binding methylation macromolecular complex regulation of intracellular estrogen receptor signaling pathway histone arginine methylation histone H3-R2 methylation histone H3-R17 methylation protein-arginine omega-N asymmetric methyltransferase activity peptidyl-arginine N-methylation histone methyltransferase activity (H3-R17 specific) histone methyltransferase activity protein homodimerization activity transcription regulatory region DNA binding positive regulation of fat cell differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of NF-kappaB transcription factor activity response to cAMP endochondral bone morphogenesis lysine-acetylated histone binding protein localization to chromatin RNA polymerase II transcription factor complex regulation of mRNA binding negative regulation of dendrite development uc009olu.1 uc009olu.2 uc009olu.3 uc009olu.4 
ENSMUST00000034707.15 Smarca4 ENSMUST00000034707.15 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, transcript variant 2 (from RefSeq NM_011417.3) Baf190a Brg1 ENSMUST00000034707.1 ENSMUST00000034707.10 ENSMUST00000034707.11 ENSMUST00000034707.12 ENSMUST00000034707.13 ENSMUST00000034707.14 ENSMUST00000034707.2 ENSMUST00000034707.3 ENSMUST00000034707.4 ENSMUST00000034707.5 ENSMUST00000034707.6 ENSMUST00000034707.7 ENSMUST00000034707.8 ENSMUST00000034707.9 NM_011417 Q3TKT4 Q3TUD7 Q6AXG8 SMCA4_MOUSE Snf2b Snf2l4 uc009omd.1 uc009omd.2 uc009omd.3 uc009omd.4 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium- dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho- RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self- renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role in regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch- dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (By similarity). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (PubMed:26138476). Binds to RNA in a promiscuous manner (PubMed:26138476). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (PubMed:26138476). In brown adipose tissue, involved in the regulation of thermogenic genes expression (PubMed:34910916). Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible developmental- and tissue-specific combinations (Probable). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors- specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (PubMed:17640523). Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin. Component of SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1/BAF190A, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes (By similarity). Component of the CREST-BRG1 complex, at least composed of SMARCA4/BRG1/BAF190A, SS18L1/CREST, HDAC1, RB1 and SP1 (By similarity). Interacts with PHF10/BAF45A (PubMed:17640523). Interacts with MYOG (PubMed:16424906). Interacts directly with IKFZ1; the interaction associates IKFZ1 with the BAF complex. Interacts with ZEB1 (via N- terminus). Interacts with NR3C1, PGR, SMARD1, TOPBP1 and ZMIM2/ZIMP7. Interacts with (via the bromodomain) with TERT; the interaction regulates Wnt-mediated signaling (By similarity). Interacts with KDM6A and KDM6B (PubMed:21095589). Interacts with TBX21 in a KDM6B-dependent manner (PubMed:21095589). Interacts with HNRNPU; this interaction occurs in embryonic stem cells and stimulates global Pol II-mediated transcription (PubMed:22162999). Interacts with ACTL6A (By similarity). Interacts with DLX1 (PubMed:26138476). Interacts with DPF2 (By similarity). Interacts with DPF3a (isoform 2 of DPF3/BAF45C) (By similarity). Interacts with HDGFL2 in a DPF3a-dependent manner (PubMed:32459350). May interact with ADNP2 (By similarity). Interacts with LETMD1 (via C-terminal); the interaction regulates transcriptional expression of thermogenic genes in brown adipose tissue (PubMed:34910916). Q3TKT4; A2BH40: Arid1a; NbExp=7; IntAct=EBI-1210244, EBI-371499; Q3TKT4; E9Q4N7: Arid1b; NbExp=5; IntAct=EBI-1210244, EBI-6900614; Q3TKT4; O09106: Hdac1; NbExp=2; IntAct=EBI-1210244, EBI-301912; Q3TKT4; P70288: Hdac2; NbExp=4; IntAct=EBI-1210244, EBI-302251; Q3TKT4; O88895: Hdac3; NbExp=2; IntAct=EBI-1210244, EBI-302263; Q3TKT4; Q99N13: Hdac9; NbExp=3; IntAct=EBI-1210244, EBI-645361; Q3TKT4; Q8VEK3: Hnrnpu; NbExp=3; IntAct=EBI-1210244, EBI-529674; Q3TKT4; Q9Z2D6: Mecp2; NbExp=2; IntAct=EBI-1210244, EBI-1188816; Q3TKT4; Q01705: Notch1; NbExp=2; IntAct=EBI-1210244, EBI-1392707; Q3TKT4; P11103: Parp1; NbExp=2; IntAct=EBI-1210244, EBI-642213; Q3TKT4; P13405: Rb1; NbExp=3; IntAct=EBI-1210244, EBI-971782; Q3TKT4; P97496: Smarcc1; NbExp=7; IntAct=EBI-1210244, EBI-648047; Q3TKT4; Q6P9Z1: Smarcd3; NbExp=3; IntAct=EBI-1210244, EBI-7525857; Q3TKT4; O70372: Tert; NbExp=2; IntAct=EBI-1210244, EBI-9662790; Q3TKT4; Q01320: Top2a; NbExp=3; IntAct=EBI-1210244, EBI-642809; Q3TKT4; Q6P1E1: Zmiz1; NbExp=2; IntAct=EBI-1210244, EBI-647033; Q3TKT4; Q62908: Csrp2; Xeno; NbExp=3; IntAct=EBI-1210244, EBI-918425; Q3TKT4; P06400: RB1; Xeno; NbExp=4; IntAct=EBI-1210244, EBI-491274; Nucleus te=Colocalizes with long non-coding RNA Evf2 in nuclear RNA clouds (PubMed:26138476). Localizes to sites of DNA damage (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TKT4-1; Sequence=Displayed; Name=2; IsoId=Q3TKT4-2; Sequence=VSP_038696; Belongs to the SNF2/RAD54 helicase family. negative regulation of transcription from RNA polymerase II promoter nucleotide binding nuclear chromatin heterochromatin cell morphogenesis RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase I CORE element sequence-specific DNA binding RNA polymerase I transcriptional preinitiation complex assembly blood vessel development vasculogenesis in utero embryonic development blastocyst growth blastocyst hatching liver development p53 binding outflow tract morphogenesis ventricular septum development DNA binding chromatin binding transcription coactivator activity transcription corepressor activity RNA binding helicase activity protein binding ATP binding nucleus nuclear euchromatin perichromatin fibrils chromatin organization nucleosome assembly nucleosome disassembly chromatin remodeling methylation-dependent chromatin silencing regulation of transcription, DNA-templated nervous system development glial cell fate determination heart development DNA-dependent ATPase activity transcription factor binding positive regulation of cell proliferation DNA methylation on cytosine within a CG sequence SWI/SNF complex hydrolase activity hydrolase activity, acting on acid anhydrides ATPase activity stem cell population maintenance neurogenesis positive regulation of Wnt signaling pathway extracellular matrix organization keratinocyte differentiation negative regulation of cell growth regulation of cell migration forebrain development hindbrain development Tat protein binding embryonic hindlimb morphogenesis aortic smooth muscle cell differentiation aorta development histone binding ATP-dependent chromatin remodeling negative regulation of apoptotic process positive regulation of DNA binding positive regulation by host of viral transcription histone H3 acetylation macromolecular complex binding positive regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein N-terminus binding embryonic organ morphogenesis epidermis morphogenesis androgen receptor binding positive regulation of sequence-specific DNA binding transcription factor activity definitive erythrocyte differentiation heart trabecula formation negative regulation of androgen receptor signaling pathway coronary vasculature development pharyngeal arch artery morphogenesis DNA polymerase binding lens fiber cell development lysine-acetylated histone binding npBAF complex nBAF complex positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter positive regulation of glucose mediated signaling pathway positive regulation of pri-miRNA transcription from RNA polymerase II promoter nucleolus uc009omd.1 uc009omd.2 uc009omd.3 uc009omd.4 
ENSMUST00000034709.7 Bcl2l10 ENSMUST00000034709.7 Bcl2-like 10 (from RefSeq NM_013479.2) B2L10_MOUSE Bcl-b Bcl2l10 Boo Diva ENSMUST00000034709.1 ENSMUST00000034709.2 ENSMUST00000034709.3 ENSMUST00000034709.4 ENSMUST00000034709.5 ENSMUST00000034709.6 NM_013479 Q3ULP5 Q7TPY8 Q9Z0F3 uc012gwy.1 uc012gwy.2 uc012gwy.3 uc012gwy.4 Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (By similarity). Increases binding of AHCYL1/IRBIT to ITPR1 (By similarity). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (By similarity). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (By similarity). Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (PubMed:27753540). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with BAX (By similarity). Interacts with BCL2 and BCL2L1/BCLX (By similarity). Interacts with APAF1 (PubMed:9878060, PubMed:9829980). Interacts with ITPR1, ITPR2 and ITPR3; the interaction with ITPR1 is increased in the presence of AHCLY1 (By similarity). Interacts with AHCYL1 (By similarity). Interacts with HIP1R (via ENTH and I/LWEQ domains) (By similarity). Interacts with CASP9 (By similarity). Interacts with BCL2L11/BIM (By similarity). Interacts with BIK (By similarity). Interacts with UBQLN4 (By similarity). Interacts with NME2/NM23-H2 (PubMed:17532299). Interacts with PMAIP1/NOXA (By similarity). Interacts with TPX2 (PubMed:27753540). Interacts with UBQLN1; in the cytoplasm (By similarity). Interacts (via BH1 domain) with BECN1 (By similarity). Mitochondrion Nucleus membrane Endoplasmic reticulum Cytoplasm, cytoskeleton, spindle Note=Localizes to mitochondria- associated endoplasmic reticulum membranes (MAMs) (By similarity). Localization to MAMs is greatly reduced under apoptotic stress conditions (By similarity). Expressed in multiple embryonic tissues (PubMed:9829980). Restricted to the ovary and testis in adult mice (PubMed:9878060, PubMed:9829980). Expressed during all phases of oocyte maturation; localized at the meiotic spindle and spindle poles during meiosis. Monoubiquitinated by UBQLN1; results in stabilization of BCL2L10 protein abundance and in relocalization from mitochondria to cytoplasm. Belongs to the Bcl-2 family. nucleus mitochondrion mitochondrial outer membrane cytosol apoptotic process intrinsic apoptotic signaling pathway in response to DNA damage membrane integral component of membrane nuclear membrane protein homodimerization activity regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process protein heterodimerization activity caspase binding extrinsic apoptotic signaling pathway in absence of ligand negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway via death domain receptors uc012gwy.1 uc012gwy.2 uc012gwy.3 uc012gwy.4 
ENSMUST00000034713.9 Ldlr ENSMUST00000034713.9 low density lipoprotein receptor, transcript variant 1 (from RefSeq NM_010700.3) ENSMUST00000034713.1 ENSMUST00000034713.2 ENSMUST00000034713.3 ENSMUST00000034713.4 ENSMUST00000034713.5 ENSMUST00000034713.6 ENSMUST00000034713.7 ENSMUST00000034713.8 LDLR_MOUSE NM_010700 P35951 Q6GTJ9 uc009omi.1 uc009omi.2 uc009omi.3 uc009omi.4 uc009omi.5 Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (PubMed:11247302). Interacts (via NPXY motif) with LDLRAP1 (via PID domain) (By similarity). Interacts with ARRB1 (By similarity). Interacts with SNX17 (PubMed:12169628). Interacts with the full-length immature form of PCSK9 (via C-terminus) (By similarity). Cell membrane ; Single-pass type I membrane protein Membrane, clathrin-coated pit Golgi apparatus Early endosome Late endosome Lysosome Note=Rapidly endocytosed upon ligand binding. The NPXY motif mediates the interaction with the clathrin adapter DAB2 and with LDLRAP1 which are involved in receptor internalization. A few residues outside the motif also play a role in the interaction. N- and O-glycosylated. Ubiquitinated by MYLIP leading to degradation. Belongs to the LDLR family. beta-amyloid binding protease binding low-density lipoprotein receptor activity calcium ion binding protein binding extracellular space cell lysosome endosome early endosome late endosome Golgi apparatus plasma membrane caveola clathrin-coated pit lipid metabolic process lipid transport endocytosis receptor-mediated endocytosis phagocytosis long-term memory steroid metabolic process cholesterol metabolic process external side of plasma membrane cell surface positive regulation of gene expression negative regulation of gene expression positive regulation of triglyceride biosynthetic process positive regulation of triglyceride catabolic process regulation of phosphatidylcholine catabolic process phospholipid transport membrane integral component of membrane basolateral plasma membrane low-density lipoprotein particle binding very-low-density lipoprotein particle receptor activity intestinal cholesterol absorption cholesterol transport low-density lipoprotein particle plasma lipoprotein particle clearance low-density lipoprotein particle clearance high-density lipoprotein particle clearance somatodendritic compartment lipoprotein metabolic process lipoprotein catabolic process cholesterol homeostasis identical protein binding receptor complex apical part of cell artery morphogenesis positive regulation of inflammatory response regulation of protein metabolic process negative regulation of protein metabolic process recycling endosome membrane response to caloric restriction cholesterol import cellular response to fatty acid cellular response to low-density lipoprotein particle stimulus receptor-mediated endocytosis involved in cholesterol transport regulation of cholesterol metabolic process beta-amyloid clearance sorting endosome negative regulation of microglial cell activation positive regulation of lysosomal protein catabolic process PCSK9-LDLR complex uc009omi.1 uc009omi.2 uc009omi.3 uc009omi.4 uc009omi.5 
ENSMUST00000034717.7 Kank2 ENSMUST00000034717.7 KN motif and ankyrin repeat domains 2 (from RefSeq NM_145611.4) Ankrd25 ENSMUST00000034717.1 ENSMUST00000034717.2 ENSMUST00000034717.3 ENSMUST00000034717.4 ENSMUST00000034717.5 ENSMUST00000034717.6 KANK2_MOUSE NM_145611 Q8BLD5 Q8BX02 Q91Z35 uc009omm.1 uc009omm.2 uc009omm.3 uc009omm.4 Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (PubMed:16024821). Interacts (non-phosphorylated form) with NCOA1; NCOA2 AND NCOA3 (By similarity). Interacts with AIFM1 (By similarity). Interacts with ARHGDIA; the interaction is direct and may regulate the interaction of ARHGDIA with RHOA, RAC1 and CDC42 (By similarity). Interacts (via ANK repeats 1-5) with KIF21A (via residues 1148-1169) (By similarity). Cytoplasm Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BX02-1; Sequence=Displayed; Name=2; IsoId=Q8BX02-2; Sequence=VSP_019430, VSP_019431; Widely expressed with highest levels in liver and skeletal muscle. Phosphorylated by casein kinase II upon estrogen stimulation (By similarity). Phosphorylation induces the release by KANK2 of NCOA1 and its translocation to the nucleus where NCOA1 can activate gene transcription (By similarity). negative regulation of transcription from RNA polymerase II promoter molecular_function cytoplasm mitochondrion apoptotic process negative regulation of cell proliferation negative regulation of intracellular estrogen receptor signaling pathway regulation of Rho protein signal transduction negative regulation of programmed cell death negative regulation of stress fiber assembly negative regulation of vitamin D receptor signaling pathway kidney epithelium development glomerular visceral epithelial cell migration negative regulation of G1/S transition of mitotic cell cycle uc009omm.1 uc009omm.2 uc009omm.3 uc009omm.4 
ENSMUST00000034720.12 Polr2m ENSMUST00000034720.12 polymerase (RNA) II (DNA directed) polypeptide M, transcript variant 1 (from RefSeq NM_178602.3) ENSMUST00000034720.1 ENSMUST00000034720.10 ENSMUST00000034720.11 ENSMUST00000034720.2 ENSMUST00000034720.3 ENSMUST00000034720.4 ENSMUST00000034720.5 ENSMUST00000034720.6 ENSMUST00000034720.7 ENSMUST00000034720.8 ENSMUST00000034720.9 GRL1A_MOUSE Grinl1a NM_178602 Q6P6I6 Q8CG13 Q9CXJ7 Q9DCQ9 uc009qoz.1 uc009qoz.2 uc009qoz.3 uc009qoz.4 Isoform 1 appears to be stable component of the Pol II(G) complex form of RNA polymerase II. Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in Mediator-dependent regulation of transcription activation. Isoform 1 acts in vitro as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II (By similarity). Isoform 1 is a component of the Pol II(G) complex, which contains the RNA polymerase II (Pol II) core complex subunits and Polr2m isoform 1 and appears to be an abundant form of Pol II. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P6I6-1; Sequence=Displayed; Name=2; IsoId=Q6P6I6-2; Sequence=VSP_032623; Belongs to the GRINL1 family. molecular_function DNA-directed 5'-3' RNA polymerase activity nucleus nuclear envelope DNA-directed RNA polymerase II, holoenzyme RNA biosynthetic process neuronal cell body maintenance of ER location uc009qoz.1 uc009qoz.2 uc009qoz.3 uc009qoz.4 
ENSMUST00000034723.6 Aldh1a2 ENSMUST00000034723.6 aldehyde dehydrogenase family 1, subfamily A2 (from RefSeq NM_009022.4) AL1A2_MOUSE Aldh1a7 ENSMUST00000034723.1 ENSMUST00000034723.2 ENSMUST00000034723.3 ENSMUST00000034723.4 ENSMUST00000034723.5 NM_009022 Q62148 Q6DI79 Raldh2 uc009qox.1 uc009qox.2 uc009qox.3 Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans- 13,14-dihydroretinoate, respectively (PubMed:15911617, PubMed:8797830). Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Lacks activity with benzaldehyde, acetaldehyde and octanal (PubMed:8797830). Displays complete lack of activity with citral (By similarity). Reaction=H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate; Xref=Rhea:RHEA:16177, ChEBI:CHEBI:15035, ChEBI:CHEBI:15036, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.36; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16178; Evidence=; Reaction=all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:42080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.36; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42081; Evidence=; Reaction=all-trans-13,14-dihydroretinal + H2O + NAD(+) = all-trans- 13,14-dihydroretinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:75119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:194182, ChEBI:CHEBI:194183; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75120; Evidence=; Cofactor metabolism; retinol metabolism. Homotetramer. Cytoplasm. Expressed in the mesoderm adjacent to the node and primitive streak during early gastrulation (PubMed:9106168). At the headfold stage, mesodermal expression is restricted to posterior regions up to the base of the headfolds (PubMed:9106168). From 10.5 dpc onwards expressed within the spinal cord in cervical and lumbar regions adjacent to the developing limbs, as well as in specific regions of the developing head, including the tooth buds, inner ear, meninges and pituitary gland, and in several viscera (PubMed:9106168). Transiently expressed in the undifferentiated somites and the optic vesicles, and more persistently along the lateral walls of the intraembryonic coelom and around the hindgut diverticulum (PubMed:9106168). Belongs to the aldehyde dehydrogenase family. Sequence=BAC37332.1; Type=Erroneous initiation; Evidence=; Sequence=CAA67666.1; Type=Erroneous initiation; Evidence=; retinoid metabolic process blood vessel development retinal dehydrogenase activity kidney development liver development regulation of endothelial cell proliferation heart looping retinoic acid biosynthetic process heart morphogenesis 3-chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity cytoplasm cytosol midgut development heart development positive regulation of cell proliferation negative regulation of cell proliferation determination of bilateral symmetry anterior/posterior pattern specification proximal/distal pattern formation positive regulation of gene expression neural crest cell development morphogenesis of embryonic epithelium oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor retinal binding neural tube development pituitary gland development neuron differentiation lung development embryonic limb morphogenesis forebrain development hindbrain development pancreas development embryonic camera-type eye development response to estradiol response to vitamin A response to cytokine embryonic forelimb morphogenesis ureter maturation retinol metabolic process retinoic acid metabolic process retinal metabolic process 9-cis-retinoic acid biosynthetic process camera-type eye development positive regulation of apoptotic process retinoic acid receptor signaling pathway perinuclear region of cytoplasm embryonic digestive tract development cardiac muscle tissue development protein homotetramerization oxidation-reduction process face development cellular response to retinoic acid retinoic acid receptor signaling pathway involved in somitogenesis uc009qox.1 uc009qox.2 uc009qox.3 
ENSMUST00000034731.10 Lipc ENSMUST00000034731.10 lipase, hepatic, transcript variant 1 (from RefSeq NM_008280.2) ENSMUST00000034731.1 ENSMUST00000034731.2 ENSMUST00000034731.3 ENSMUST00000034731.4 ENSMUST00000034731.5 ENSMUST00000034731.6 ENSMUST00000034731.7 ENSMUST00000034731.8 ENSMUST00000034731.9 Hpl LIPC_MOUSE NM_008280 P27656 Q8VC44 uc009qos.1 uc009qos.2 Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (By similarity). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (By similarity). Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + di-(9Z)-octadecenoylglycerol + H(+); Xref=Rhea:RHEA:38575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38576; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38699, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669, ChEBI:CHEBI:76083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38700; Evidence=; Reaction=1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+); Xref=Rhea:RHEA:40475, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:35020, ChEBI:CHEBI:76478; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40476; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:41384, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41385; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)- octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38511, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52333, ChEBI:CHEBI:73990; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38512; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38391, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75824; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38392; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine; Xref=Rhea:RHEA:40499, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:64765, ChEBI:CHEBI:74617; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40500; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+); Xref=Rhea:RHEA:38651, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75735, ChEBI:CHEBI:75938; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38652; Evidence=; Homodimer. Secreted Belongs to the AB hydrolase superfamily. Lipase family. lysophospholipase activity triglyceride lipase activity protein binding extracellular region extracellular space early endosome late endosome microvillus lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process triglyceride metabolic process phosphatidylserine metabolic process heparin binding cholesterol metabolic process lipid binding phosphatidylcholine 1-acylhydrolase activity cell surface heparan sulfate proteoglycan biosynthetic process lipid catabolic process lipase activity transferase activity, transferring acyl groups hydrolase activity triglyceride catabolic process low-density lipoprotein particle binding cholesterol transport apolipoprotein binding high-density lipoprotein particle chylomicron remodeling very-low-density lipoprotein particle remodeling low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling chylomicron remnant clearance low-density lipoprotein particle clearance chylomicron binding cholesterol homeostasis heparan sulfate proteoglycan binding phosphatidylethanolamine metabolic process neutral lipid catabolic process phosphatidylcholine metabolic process phosphatidic acid metabolic process glycerophospholipid catabolic process acylglycerol lipase activity protein oligomerization carboxylic ester hydrolase activity triglyceride homeostasis regulation of plasma lipoprotein particle levels uc009qos.1 uc009qos.2 
ENSMUST00000034734.9 Dnaaf4 ENSMUST00000034734.9 dynein axonemal assembly factor 4, transcript variant 1 (from RefSeq NM_026314.3) DAAF4_MOUSE Dnaaf4 Dyx1c1 ENSMUST00000034734.1 ENSMUST00000034734.2 ENSMUST00000034734.3 ENSMUST00000034734.4 ENSMUST00000034734.5 ENSMUST00000034734.6 ENSMUST00000034734.7 ENSMUST00000034734.8 Ekn1 G3X916 NM_026314 Q8R368 uc009qqj.1 uc009qqj.2 uc009qqj.3 uc009qqj.4 Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity (By similarity). Axonemal dynein assembly factor required for ciliary motility. Interacts with ZMYND10 (By similarity). Interacts with ESR1 and ESR2. Interacts with STUB1 (By similarity). Interacts with DNAAF2 (By similarity). Interacts with CCT3, CCT4, CCT5 and CCT8 (PubMed:23872636). Interacts with DNAAF6/PIH1D3 (By similarity). Nucleus Cytoplasm Dynein axonemal particle Cell projection, neuron projection neuron migration cilium movement epithelial cilium movement protein binding extracellular region nucleus cytoplasm centrosome cytosol plasma membrane determination of left/right symmetry nervous system development heart development learning or memory estrogen receptor binding regulation of intracellular estrogen receptor signaling pathway outer dynein arm assembly inner dynein arm assembly regulation of proteasomal protein catabolic process non-motile cilium uc009qqj.1 uc009qqj.2 uc009qqj.3 uc009qqj.4 
ENSMUST00000034737.13 Khdc3 ENSMUST00000034737.13 KH domain containing 3, subcortical maternal complex member, transcript variant 1 (from RefSeq NM_025890.3) A7YIL2 ENSMUST00000034737.1 ENSMUST00000034737.10 ENSMUST00000034737.11 ENSMUST00000034737.12 ENSMUST00000034737.2 ENSMUST00000034737.3 ENSMUST00000034737.4 ENSMUST00000034737.5 ENSMUST00000034737.6 ENSMUST00000034737.7 ENSMUST00000034737.8 ENSMUST00000034737.9 KHDC3_MOUSE NM_025890 Q9CRD6 Q9CWU5 uc009qqy.1 uc009qqy.2 uc009qqy.3 uc009qqy.4 As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (PubMed:29125140, PubMed:33115731). Regulates homologous recombination-mediated DNA repair via recruitment of RAD51 to sites of DNA double-strand breaks, and sustainment of PARP1 activity, which in turn modulates downstream ATM or ATR activation (PubMed:25936915, PubMed:33115731). Activation of ATM or ATR in response to DNA double-strand breaks may be cell-type specific (PubMed:25936915, PubMed:33115731). Its role in DNA double- strand break repair is independent of its role in restarting stalled replication forks (PubMed:29125140). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:18804437, PubMed:29125140, PubMed:28992324, PubMed:31575650). Required for maintenance of euploidy during cleavage- stage embryogenesis (PubMed:19376971). Required for the formation of F- actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (PubMed:25208553, PubMed:31575650). Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process (PubMed:19376971). Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (PubMed:19376971). Promotes neural stem cell neurogenesis and neuronal differentiation in the hippocampus (PubMed:33115731). May regulate normal development of learning, memory and anxiety (PubMed:33115731). Capable of binding RNA (PubMed:22276159). Component of the subcortical maternal complex (SCMC), at least composed of NLRP5, KHDC3, OOEP, and TLE6 (PubMed:18057100, PubMed:18804437, PubMed:28992324). Within the complex, interacts with NLRP5, OOEP and TLE6 (PubMed:18057100, PubMed:18804437). The SCMC may facilitate translocation of its components between the nuclear and cytoplasmic compartments (By similarity). Forms a scaffold complex with OOEP/FLOPED, and interacts with BLM and TRIM25 at DNA replication forks (PubMed:29125140). Interacts with PARP1; the interaction is increased following the formation of DNA double-strand breaks (PubMed:25936915). Interacts (via C-terminus) with NUMA1 (PubMed:25936915). Q9CWU5; Q9R1M5: Nlrp5; NbExp=3; IntAct=EBI-2905804, EBI-2905719; Cytoplasm, cell cortex cleus Mitochondrion Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Chromosome Note=Localized to centrosomes during interphase and mitosis (PubMed:25936915). Localizes to sites of DNA double-strand break repair (By similarity). Localization to the mitochondrion during apoptosis following phosphorylation of Ser-349 (PubMed:25936915). Expressed in the subcortex of oocytes (PubMed:25208553). Located throughout the cell cortex of ovulated eggs in a complex with NLRP5 (PubMed:18057100). After fertilization, restricted to the apical cortex and excluded from regions of cell-cell contact (PubMed:18057100). Event=Alternative splicing; Named isoforms=3; Name=1 ; Synonyms=Filia 1.6 ; IsoId=Q9CWU5-1; Sequence=Displayed; Name=2 ; Synonyms=Filia 1.2 ; IsoId=Q9CWU5-2; Sequence=VSP_040951, VSP_040952; Name=3 ; IsoId=Q9CWU5-3; Sequence=VSP_040950; Detected in ovary, but not in testis or somatic tissues. In the ovary, expressed in growing oocytes. Expressed in the brain at low levels during fetal development, from 13.5 dpc to 18.5 dpc, however significantly increased after birth from P1 to P60 (PubMed:33115731). Highly expressed in neural stem progenitor cells in the hippocampus after birth (PubMed:33115731). [Isoform 1]: Expressed in growing oocytes but diminishes in fully grown oocytes (PubMed:18057100). Detected at very low levels in morula and early blastocyst (PubMed:18057100). [Isoform 2]: Expressed in growing oocytes, ovulated eggs and preimplantation embryos up to the morula stage and decreases markedly at the blastocyst stage (at protein level). Induced by ultraviolet light, etoposide, doxorubicin, camptothecin and hydroxyl urea in embryonic stem cells (PubMed:25936915). Induced by etoposide and hydroxy urea in neural stem cells (PubMed:33115731). Contains 1 atypical KH domain, which is still capable of binding RNA. Phosphorylation at Ser-151 is required to promote stalled fork restart. Reduced fecundity and impaired preimplantation embryo development with a high incidence of aneuploidy due to abnormal spindle assembly, chromosomal misalignment and spindle assembly checkpoint inactivation (PubMed:19376971). Loss of cytoplasmic lattices and aberrant organelle distribution in oocytes (PubMed:31575650). Increase in abnormal embryonic structure and loss of the embryo following compromised post-implantation embryo development (PubMed:29125140). Knockout mice show normal brain structure and weight (PubMed:33115731). Increased DNA double-strand breaks in hippocampus neural stem cells at P1 to 1 year of age (PubMed:33115731). Reduced hippocampal neural stem cell proliferation from P7 to P60 (PubMed:33115731). Reduced differentiation of neurons and dendritic spines formation in the dentate gyrus from P13 to P66 (PubMed:33115731). Impaired hippocampus-dependent spatial learning, memory and anxiety from 2 months to 1 year of age (PubMed:33115731). Belongs to the KHDC1 family. RNA binding protein binding cytoplasm cell cortex protein phosphorylation cell cycle mitotic spindle assembly checkpoint multicellular organism development macromolecular complex apical cortex mitotic spindle assembly uc009qqy.1 uc009qqy.2 uc009qqy.3 uc009qqy.4 
ENSMUST00000034738.14 Rsl24d1 ENSMUST00000034738.14 ribosomal L24 domain containing 1 (from RefSeq NM_198609.2) ENSMUST00000034738.1 ENSMUST00000034738.10 ENSMUST00000034738.11 ENSMUST00000034738.12 ENSMUST00000034738.13 ENSMUST00000034738.2 ENSMUST00000034738.3 ENSMUST00000034738.4 ENSMUST00000034738.5 ENSMUST00000034738.6 ENSMUST00000034738.7 ENSMUST00000034738.8 ENSMUST00000034738.9 NM_198609 Q99L28 RLP24_MOUSE uc009qra.1 uc009qra.2 uc009qra.3 Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity). Associated with nucleolar and cytoplasmic pre-60S particles (By similarity). At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 (By similarity). Nucleus, nucleolus Belongs to the eukaryotic ribosomal protein eL24 family. ribosomal large subunit assembly RNA binding structural constituent of ribosome nucleus nucleolus ribosome translation cytosolic large ribosomal subunit ribosome biogenesis assembly of large subunit precursor of preribosome uc009qra.1 uc009qra.2 uc009qra.3 
ENSMUST00000034739.12 Rnf111 ENSMUST00000034739.12 ring finger 111, transcript variant 1 (from RefSeq NM_033604.3) ENSMUST00000034739.1 ENSMUST00000034739.10 ENSMUST00000034739.11 ENSMUST00000034739.2 ENSMUST00000034739.3 ENSMUST00000034739.4 ENSMUST00000034739.5 ENSMUST00000034739.6 ENSMUST00000034739.7 ENSMUST00000034739.8 ENSMUST00000034739.9 NM_033604 Q3UVL7 Q6NSW2 Q7TMR3 Q8C881 Q8CBC0 Q99ML9 RN111_MOUSE Rnf111 uc009qoe.1 uc009qoe.2 E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (PubMed:11298452). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (By similarity). Associates with UBE2D2 as an E2 enzyme (By similarity). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23530056). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (By similarity). Mediates ubiquitination and degradation of sumoylated PML (PubMed:23530056). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (PubMed:23530056). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Binds free ubiquitin non-covalently via its RING- type zinc finger. Ubiquitin-binding leads to enhance the E3 ubiquitin- protein ligase activity by stabilizing the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the 'closed' conformation and activating ubiquitin transfer. Protein modification; protein ubiquitination. Monomer (By similarity). Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON (PubMed:14657019). Interacts with (phosphorylated) SMAD2 and SMAD3 (PubMed:17341133). Part of a complex containing RNF111, AXIN1 and SMAD7 (By similarity). Interacts (via SIM domains) with SUMO1 and SUMO2 (PubMed:23530056). Q99ML9; O35625: Axin1; NbExp=4; IntAct=EBI-646015, EBI-2365912; Q99ML9; O15169: AXIN1; Xeno; NbExp=5; IntAct=EBI-646015, EBI-710484; Q99ML9; O15105: SMAD7; Xeno; NbExp=2; IntAct=EBI-646015, EBI-3861591; Nucleus Cytoplasm Nucleus, PML body Note=Upon TGF-beta treatment, translocates from nucleus to cytosol. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99ML9-1; Sequence=Displayed; Name=2; IsoId=Q99ML9-2; Sequence=VSP_023842; Ubiquitously expressed. Ubiquitously expressed from ES cells to midgestation. The SUMO interaction motifs (SIMs) mediates the binding to polysumoylated substrate. The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity and binds directly to free ubiquitin. Non-covalent ubiquitin-binding stabilizes the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the 'closed' conformation and stimulates ubiquitin transfer. Mice rarely develop beyond 15 somites, have a reduced head, fail to undergo turning and die at midgestation. Belongs to the Arkadia family. protein polyubiquitination ubiquitin-protein transferase activity protein binding nucleus nucleoplasm cytoplasm cytosol DNA repair ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus multicellular organism development pattern specification process protein ubiquitination PML body transferase activity positive regulation of transforming growth factor beta receptor signaling pathway ubiquitin-dependent SMAD protein catabolic process positive regulation of protein ubiquitination SUMO polymer binding macromolecular complex positive regulation of transcription, DNA-templated SMAD binding metal ion binding ubiquitin protein ligase activity uc009qoe.1 uc009qoe.2 
ENSMUST00000034740.15 Nedd4 ENSMUST00000034740.15 neural precursor cell expressed, developmentally down-regulated 4, transcript variant 1 (from RefSeq NM_010890.4) ENSMUST00000034740.1 ENSMUST00000034740.10 ENSMUST00000034740.11 ENSMUST00000034740.12 ENSMUST00000034740.13 ENSMUST00000034740.14 ENSMUST00000034740.2 ENSMUST00000034740.3 ENSMUST00000034740.4 ENSMUST00000034740.5 ENSMUST00000034740.6 ENSMUST00000034740.7 ENSMUST00000034740.8 ENSMUST00000034740.9 Kiaa0093 NEDD4_MOUSE NM_010890 Nedd-4 Nedd4-1 Nedd4a O08758 P46935 Q3UZI2 Q8BGB3 Rpf1 uc009qqe.1 uc009qqe.2 uc009qqe.3 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (PubMed:18286479). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (PubMed:20159449). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (By similarity). Ubiquitinates DAZAP2, leading to its proteasomal degradation (By similarity). Ubiquitinates POLR2A (By similarity). Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence=; Activated by NDFIP1- and NDFIP2-binding. Protein modification; protein ubiquitination. Binds SCNN1A, SCNN1B and SCNN1G. Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase and may induce its recruitment to exosomes. Interacts with UBE2D2 (PubMed:9182527). Binds, in vitro, through the WW2 and WW3 domains, to neural isoforms of ENAH that contain the PPSY motif (PubMed:9407065). Interacts with BEAN1, LITAF, RNF11, WBP1, WBP2, PMEPAI and PRRG2 (PubMed:11042109). Interacts with murine leukemia virus Gag polyprotein (via PPXY motif) (PubMed:15908698). Interacts (via C2 domain) with GRB10 (via SH2 domain) (PubMed:12697834, PubMed:15060076, PubMed:18286479, PubMed:20980250). Interacts with ERBB4 (PubMed:19193720, PubMed:19047365). Interacts with TNIK; the interaction is direct, allows the TNIK-dependent recruitment of RAP2A and its ubiquitination by NEDD4 (PubMed:20159449). Interacts (via WW3 domain) with TNK2; EGF promotes this interaction. Interacts (via WW3 domain) with FGFR1 (via C-terminus). Interacts with OTUD7B (By similarity). Interacts with ISG15 (By similarity). Interacts (via WW domain) with RAPGEF2; this interaction leads to ubiquitination and degradation via the proteasome pathway. Interacts (via WW domains) with ARRDC3 (via PPXY motifs) (By similarity). Interacts with LAPTM4B; may play a role in the lysosomal sorting of LAPTM4B (By similarity). Interacts with ZBTB7B (PubMed:28784777). Interacts with PRRG4 (via cytoplasmic domain) (By similarity). Interacts directly with LDLRAD3; this interaction promotes NEDD4 auto-ubiquitination (By similarity). Interacts with ADRB2 (By similarity). Interacts (via WW domains) with DAZAP2 (via PPAY motif) (By similarity). P46935; Q9EQG5: Bean1; NbExp=3; IntAct=EBI-773516, EBI-6304006; P46935; Q60760: Grb10; NbExp=7; IntAct=EBI-773516, EBI-861810; P46935; Q9JLJ0: Litaf; NbExp=5; IntAct=EBI-773516, EBI-643664; P46935; Q8R0W6: Ndfip1; NbExp=5; IntAct=EBI-773516, EBI-6304119; P46935; Q9D7R2: Pmepa1; NbExp=5; IntAct=EBI-773516, EBI-6304097; P46935; Q8R182: Prrg2; NbExp=5; IntAct=EBI-773516, EBI-6304055; P46935; Q9QYK7: Rnf11; NbExp=4; IntAct=EBI-773516, EBI-4405826; P46935; P97764: Wbp1; NbExp=3; IntAct=EBI-773516, EBI-6304160; P46935; P97765: Wbp2; NbExp=5; IntAct=EBI-773516, EBI-6304181; Cytoplasm Nucleus Cell membrane ; Peripheral membrane protein Note=Predominantly cytoplasmic but also located in the nucleus (By similarity). Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (PubMed:18286479). May be recruited to exosomes by NDFIP1 (By similarity). Brain. The WW domains mediate interaction with PPxY motif-containing proteins (By similarity). The WW domains mediate interaction with LITAF, RNF11, WBP1, WBP2, PMEPAI, NDFIP1 and PRRG2 (PubMed:11042109). Undergoes 'Lys-29'-linked auto-ubiquitination at Lys-847 and serves as a scaffold for recruiting USP13 to form an NEDD4-USP13 deubiquitination complex. Lethal during late gestation. Embryos show a retarded development and defects in vasculogenesis and angiogenesis. A cysteine residue is required for ubiquitin-thioester formation. Sequence=AAB63360.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter ubiquitin ligase complex protein polyubiquitination chromatin adaptive immune response outflow tract morphogenesis endocardial cushion development ubiquitin-protein transferase activity protein binding cytoplasm Golgi apparatus cytosol plasma membrane microvillus cell cortex ubiquitin-dependent protein catabolic process protein monoubiquitination protein targeting to lysosome lysosomal transport nervous system development neuromuscular junction development protein C-terminus binding negative regulation of sodium ion transport negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage positive regulation of phosphatidylinositol 3-kinase signaling membrane protein ubiquitination transferase activity transmission of virus sodium channel inhibitor activity protein domain specific binding negative regulation of vascular endothelial growth factor receptor signaling pathway neuron projection development receptor internalization beta-2 adrenergic receptor binding receptor catabolic process cellular response to UV regulation of ion transmembrane transport ionotropic glutamate receptor binding T cell activation regulation of membrane potential glucocorticoid receptor signaling pathway ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway dendritic spine development involved in symbiotic interaction membrane raft positive regulation of protein catabolic process positive regulation of nucleocytoplasmic transport perinuclear region of cytoplasm blood vessel morphogenesis regulation of dendrite morphogenesis regulation of synapse organization phosphoserine binding phosphothreonine binding progesterone receptor signaling pathway ubiquitin protein ligase activity RNA polymerase binding proline-rich region binding protein K63-linked ubiquitination glutamatergic synapse postsynaptic cytosol regulation of protein catabolic process at postsynapse, modulating synaptic transmission regulation of potassium ion transmembrane transporter activity negative regulation of sodium ion transmembrane transporter activity uc009qqe.1 uc009qqe.2 uc009qqe.3 
ENSMUST00000034742.8 Ccnb2 ENSMUST00000034742.8 cyclin B2 (from RefSeq NM_007630.2) CCNB2_MOUSE Cycb2 ENSMUST00000034742.1 ENSMUST00000034742.2 ENSMUST00000034742.3 ENSMUST00000034742.4 ENSMUST00000034742.5 ENSMUST00000034742.6 ENSMUST00000034742.7 NM_007630 P30276 Q922E9 uc009qny.1 uc009qny.2 uc009qny.3 Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Accumulates steadily during G2 and is abruptly destroyed at mitosis. Belongs to the cyclin family. Cyclin AB subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein kinase holoenzyme complex in utero embryonic development nucleus cytoplasm centrosome cytosol protein phosphorylation cell cycle microtubule cytoskeleton membrane cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding regulation of growth T cell homeostasis mitotic cell cycle phase transition thymus development cell division protein kinase activity uc009qny.1 uc009qny.2 uc009qny.3 
ENSMUST00000034745.9 Myo1e ENSMUST00000034745.9 myosin IE (from RefSeq NM_181072.3) E9Q634 ENSMUST00000034745.1 ENSMUST00000034745.2 ENSMUST00000034745.3 ENSMUST00000034745.4 ENSMUST00000034745.5 ENSMUST00000034745.6 ENSMUST00000034745.7 ENSMUST00000034745.8 MYO1E_MOUSE Myr3 NM_181072 Q80X36 Q91ZI4 uc009qnx.1 uc009qnx.2 uc009qnx.3 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain (By similarity). Involved in clathrin-mediated endocytosis and intracellular movement of clathrin- coated ve (By similarity)sicles. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14 (By similarity). Interacts with CALM and F-actin. Interacts (via SH3 domain) with SYNJ1, DNM1 and DNM2. Interacts with ARL14EP. Interacts with CARMIL1. Cytoplasm Cell junction Cytoplasmic vesicle Cytoplasmic vesicle, clathrin-coated vesicle Cytoplasm, cytoskeleton Note=In podocytes, it localizes close to and is associated with the cytoplasmic membrane, with enrichment at the lamellipodia tips. Colocalizes with F-actin (By similarity). Detected in cytoplasmic punctae. Detected in kidney glomeruli (at protein level). Detected in utricle. No visible phenotype at birth. Mice exhibit massive proteinuria, combined with the presence of leukocytes and hemoglobin in the urine. They develop enlarged kidneys, present damage to the glomeruli, renal inflammation and fibrosis. In the glomeruli, the thickness of the basement membrane is increased, and podocytes fail to develop normal foot processes. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1). nucleotide binding vasculogenesis in utero embryonic development kidney development glomerular filtration motor activity actin binding calmodulin binding ATP binding cytoplasm cytoskeleton brush border cell-cell junction adherens junction nitrogen compound metabolic process endocytosis lipid binding myosin complex cell junction hemopoiesis clathrin-coated vesicle cytoplasmic vesicle cuticular plate glomerular basement membrane development macromolecular complex phosphatidylinositol binding post-embryonic hemopoiesis ATPase activity, coupled macromolecular complex binding clathrin-coated endocytic vesicle platelet-derived growth factor receptor signaling pathway actin filament binding glomerular visceral epithelial cell development uc009qnx.1 uc009qnx.2 uc009qnx.3 
ENSMUST00000034746.10 Mns1 ENSMUST00000034746.10 meiosis-specific nuclear structural protein 1, transcript variant 1 (from RefSeq NM_008613.4) ENSMUST00000034746.1 ENSMUST00000034746.2 ENSMUST00000034746.3 ENSMUST00000034746.4 ENSMUST00000034746.5 ENSMUST00000034746.6 ENSMUST00000034746.7 ENSMUST00000034746.8 ENSMUST00000034746.9 MNS1_MOUSE NM_008613 Q61884 uc009qpx.1 uc009qpx.2 uc009qpx.3 uc009qpx.4 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly (PubMed:22396656). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (By similarity). Able to form oligomers (PubMed:22396656). Interacts with ODAD1 (By similarity). Interacts with BBOF1 (PubMed:37198331). Nucleus Cytoplasm, cytoskeleton, flagellum axoneme toplasm, cytoskeleton, cilium axoneme Note=Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. High expression in testis (PubMed:22396656). Expressed in pachytene spermatocytes and post-meiotic spermatids (PubMed:8032679, PubMed:22396656). Expressed in the ventral embryonic node at developmental stage 8 dpc. MNS1-deficient mice display situs inversus and hydrocephalus. They are sterile, exhibit a sharp reduction in sperm production, and remnant spermatozoa are immotile with abnormal short tails. Belongs to the MNS1 family. nucleus nuclear envelope intermediate filament axoneme spermatogenesis motile cilium sperm flagellum identical protein binding cilium organization positive regulation of cilium assembly meiotic cell cycle left/right axis specification uc009qpx.1 uc009qpx.2 uc009qpx.3 uc009qpx.4 
ENSMUST00000034749.16 Fam81a ENSMUST00000034749.16 family with sequence similarity 81, member A (from RefSeq NM_029784.2) ENSMUST00000034749.1 ENSMUST00000034749.10 ENSMUST00000034749.11 ENSMUST00000034749.12 ENSMUST00000034749.13 ENSMUST00000034749.14 ENSMUST00000034749.15 ENSMUST00000034749.2 ENSMUST00000034749.3 ENSMUST00000034749.4 ENSMUST00000034749.5 ENSMUST00000034749.6 ENSMUST00000034749.7 ENSMUST00000034749.8 ENSMUST00000034749.9 FA81A_MOUSE NM_029784 Q3UXZ6 Q8BQV1 Q8C548 Q8R3B5 Q9D369 uc009qnu.1 uc009qnu.2 uc009qnu.3 Belongs to the FAM81 family. molecular_function cellular_component biological_process uc009qnu.1 uc009qnu.2 uc009qnu.3 
ENSMUST00000034751.6 Gcnt3 ENSMUST00000034751.6 glucosaminyl (N-acetyl) transferase 3, mucin type (from RefSeq NM_028087.2) A2TIK7 ENSMUST00000034751.1 ENSMUST00000034751.2 ENSMUST00000034751.3 ENSMUST00000034751.4 ENSMUST00000034751.5 GCNT3_MOUSE NM_028087 Q5JCT0 Q8VCX9 Q9D8A3 uc009qnt.1 uc009qnt.2 Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I- branching enzyme activity by converting linear into branched poly-N- acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. Reaction=O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl- (1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:56212, Rhea:RHEA-COMP:13922, Rhea:RHEA- COMP:14419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:137949, ChEBI:CHEBI:139605; EC=2.4.1.102; Evidence=; Reaction=O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D- glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D- glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl- [protein] + H(+) + UDP; Xref=Rhea:RHEA:56216, Rhea:RHEA-COMP:13923, Rhea:RHEA-COMP:14420, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:137950, ChEBI:CHEBI:139607; EC=2.4.1.102; Evidence=; Reaction=a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)- beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta- D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal- (1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:54820, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:138371, ChEBI:CHEBI:138372; EC=2.4.1.150; Evidence=; Reaction=3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D- galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D- glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl- [protein] + H(+) + UDP; Xref=Rhea:RHEA:56188, Rhea:RHEA-COMP:11691, Rhea:RHEA-COMP:14412, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:87079, ChEBI:CHEBI:139581; EC=2.4.1.148; Evidence=; Reaction=3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D- galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D- glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl- beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L- threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:56192, Rhea:RHEA- COMP:11692, Rhea:RHEA-COMP:14413, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:87080, ChEBI:CHEBI:139580; EC=2.4.1.148; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein N-glycosylated. Belongs to the glycosyltransferase 14 family. Sequence=AAH18297.1; Type=Erroneous initiation; Evidence=; Sequence=BAB25548.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Name=Functional Glycomics Gateway - GTase; Note=core 2 beta 6 GlcNAc T3; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_575"; Golgi membrane immunoglobulin production in mucosal tissue beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Golgi apparatus protein glycosylation protein O-linked glycosylation N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity tissue morphogenesis intestinal absorption kidney morphogenesis uc009qnt.1 uc009qnt.2 
ENSMUST00000034754.12 Bnip2 ENSMUST00000034754.12 BCL2/adenovirus E1B interacting protein 2, transcript variant beta (from RefSeq NM_016787.4) BNIP2_MOUSE ENSMUST00000034754.1 ENSMUST00000034754.10 ENSMUST00000034754.11 ENSMUST00000034754.2 ENSMUST00000034754.3 ENSMUST00000034754.4 ENSMUST00000034754.5 ENSMUST00000034754.6 ENSMUST00000034754.7 ENSMUST00000034754.8 ENSMUST00000034754.9 NM_016787 Nip2l O54940 Q8K4H0 uc009qno.1 uc009qno.2 uc009qno.3 uc009qno.4 uc009qno.5 Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins (By similarity). Cytoplasm Cytoplasm, perinuclear region Note=Localizes to the nuclear envelope region and to other cytoplasmic structures. blastocyst development exopolyphosphatase activity nuclear envelope cytoplasm centriole cytosol polyphosphate catabolic process apoptotic process centrosome cycle spindle pole centrosome intracellular membrane-bounded organelle positive regulation of MAPK cascade positive regulation of neuron differentiation perinuclear region of cytoplasm positive regulation of small GTPase mediated signal transduction striated muscle cell differentiation uc009qno.1 uc009qno.2 uc009qno.3 uc009qno.4 uc009qno.5 
ENSMUST00000034756.15 Anxa2 ENSMUST00000034756.15 annexin A2, transcript variant 1 (from RefSeq NM_007585.4) Anxa2 ENSMUST00000034756.1 ENSMUST00000034756.10 ENSMUST00000034756.11 ENSMUST00000034756.12 ENSMUST00000034756.13 ENSMUST00000034756.14 ENSMUST00000034756.2 ENSMUST00000034756.3 ENSMUST00000034756.4 ENSMUST00000034756.5 ENSMUST00000034756.6 ENSMUST00000034756.7 ENSMUST00000034756.8 ENSMUST00000034756.9 NM_007585 Q542G9 Q542G9_MOUSE uc009qng.1 uc009qng.2 uc009qng.3 Membrane Secreted, extracellular space, extracellular matrix, basement membrane A pair of annexin repeats may form one binding site for calcium and phospholipid. Belongs to the annexin family. angiogenesis ruffle membrane raft assembly positive regulation of receptor recycling positive regulation of protein phosphorylation protease binding phospholipase inhibitor activity calcium ion binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm lysosomal membrane endosome lipid particle cytosol plasma membrane cell cortex membrane budding body fluid secretion cytoskeletal protein binding cell surface membrane Rab GTPase binding phospholipase A2 inhibitor activity midbody positive regulation of vesicle fusion late endosome membrane vesicle negative regulation of low-density lipoprotein particle receptor catabolic process macromolecular complex osteoclast development identical protein binding negative regulation of catalytic activity positive regulation of vacuole organization negative regulation of development of symbiont involved in interaction with host macropinosome S100 protein binding bone sialoprotein binding membrane raft positive regulation of fibroblast proliferation calcium-dependent protein binding perinuclear region of cytoplasm protein heterotetramerization catabolism by host of symbiont protein negative regulation by host of symbiont molecular function extracellular exosome protein localization to plasma membrane response to thyroid hormone molecular function regulator positive regulation of low-density lipoprotein particle clearance positive regulation of low-density lipoprotein particle receptor binding positive regulation of low-density lipoprotein receptor activity positive regulation of receptor-mediated endocytosis involved in cholesterol transport PCSK9-AnxA2 complex uc009qng.1 uc009qng.2 uc009qng.3 
ENSMUST00000034761.15 Ice2 ENSMUST00000034761.15 interactor of little elongation complex ELL subunit 2 (from RefSeq NM_145618.3) B0V2P1 ENSMUST00000034761.1 ENSMUST00000034761.10 ENSMUST00000034761.11 ENSMUST00000034761.12 ENSMUST00000034761.13 ENSMUST00000034761.14 ENSMUST00000034761.2 ENSMUST00000034761.3 ENSMUST00000034761.4 ENSMUST00000034761.5 ENSMUST00000034761.6 ENSMUST00000034761.7 ENSMUST00000034761.8 ENSMUST00000034761.9 ICE2_MOUSE NM_145618 Narg2 Q3UZ18 Q66JS8 Q7TNL8 Q8BQZ1 Q8VEI2 uc009qnf.1 uc009qnf.2 uc009qnf.3 Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via C-terminus domain). Interacts with ELL (By similarity). Nucleus Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UZ18-1; Sequence=Displayed; Name=2; IsoId=Q3UZ18-2; Sequence=VSP_027442, VSP_027443; Expressed in brain, kidney, liver and testis. Expressed in brain from 13 dpc to P0, and down- regulated after birth. Down-regulated during neuronal differentiation, probably by NMDA receptor. Belongs to the ICE2 family. Sequence=AAH18458.1; Type=Erroneous initiation; Evidence=; Sequence=AAH80786.1; Type=Frameshift; Evidence=; nucleus nucleoplasm cytosol transcription elongation factor complex Cajal body nuclear body transcriptionally active chromatin histone locus body snRNA transcription from RNA polymerase II promoter snRNA transcription from RNA polymerase III promoter positive regulation of transcription from RNA polymerase III promoter uc009qnf.1 uc009qnf.2 uc009qnf.3 
ENSMUST00000034763.10 Rp9 ENSMUST00000034763.10 retinitis pigmentosa 9 (human) (from RefSeq NM_018739.2) ENSMUST00000034763.1 ENSMUST00000034763.2 ENSMUST00000034763.3 ENSMUST00000034763.4 ENSMUST00000034763.5 ENSMUST00000034763.6 ENSMUST00000034763.7 ENSMUST00000034763.8 ENSMUST00000034763.9 NM_018739 Q3TH81 Q3TH81_MOUSE Rp9 Rp9h rp9 uc009ooq.1 uc009ooq.2 uc009ooq.3 uc009ooq.4 uc009ooq.5 nucleus cytosol RNA splicing cognition uc009ooq.1 uc009ooq.2 uc009ooq.3 uc009ooq.4 uc009ooq.5 
ENSMUST00000034774.9 Itga11 ENSMUST00000034774.9 integrin alpha 11 (from RefSeq NM_176922.6) A0A0B4J1F0 A0A0B4J1F0_MOUSE ENSMUST00000034774.1 ENSMUST00000034774.2 ENSMUST00000034774.3 ENSMUST00000034774.4 ENSMUST00000034774.5 ENSMUST00000034774.6 ENSMUST00000034774.7 ENSMUST00000034774.8 Itga11 NM_176922 uc009qal.1 uc009qal.2 uc009qal.3 uc009qal.4 Membrane ingle-pass type I membrane protein Belongs to the integrin alpha chain family. collagen binding focal adhesion substrate-dependent cell migration cell adhesion cell-matrix adhesion integrin-mediated signaling pathway integrin complex membrane integral component of membrane cell adhesion mediated by integrin integrin alpha11-beta1 complex collagen receptor activity collagen-activated signaling pathway collagen binding involved in cell-matrix adhesion uc009qal.1 uc009qal.2 uc009qal.3 uc009qal.4 
ENSMUST00000034775.10 Fem1b ENSMUST00000034775.10 fem 1 homolog b (from RefSeq NM_010193.4) ENSMUST00000034775.1 ENSMUST00000034775.2 ENSMUST00000034775.3 ENSMUST00000034775.4 ENSMUST00000034775.5 ENSMUST00000034775.6 ENSMUST00000034775.7 ENSMUST00000034775.8 ENSMUST00000034775.9 F1aa FEM1B_MOUSE Fem1b Kiaa0396 NM_010193 Q3TV57 Q3ULQ3 Q3V148 Q80U13 Q99NC9 Q9QZL3 Q9Z2G0 uc009qam.1 uc009qam.2 uc009qam.3 uc009qam.4 uc009qam.5 uc009qam.6 Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation (By similarity). Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2(FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS) (PubMed:32941802, PubMed:34562363). Mechanistically, recognizes and binds reduced FNIP1 through two interface zinc ions, which act as a molecular glue that recruit reduced FNIP1 to FEM1B (PubMed:34562363). Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity (By similarity). Promotes ubiquitination and degradation of ANKRD37 (PubMed:21723927). Promotes ubiquitination and degradation of SLBP (By similarity). Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (By similarity). Also involved in glucose homeostasis in pancreatic islet (PubMed:16024793). May also act as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (By similarity). Activity of the CRL2(FEM1B) complex toward FNIP1 is inhibited by BEX family proteins (BEX1, BEX2, BEX3 and/or BEX4) in absence of reductive stress (PubMed:34562363). Mechanistically, BEX proteins act as pseudosubstrate inhibitors that associate with FEM1B via zinc in absence of reductive stress, thereby preventing association between FEM1B and FNIP1 (PubMed:34562363). Protein modification; protein ubiquitination. Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter FEM1B (PubMed:32941802). Homooligomer (By similarity). Interacts with PPM1F and PHTF1 (PubMed:15601915). Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A. Interacts with CHEK1 (By similarity). Interacts with NKX3-1 (PubMed:18816836). Cytoplasm cleus Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin. Expressed in pancreatic islets, within both beta cells and non-beta cells (at protein level) (PubMed:16024793). Highly expressed in adult testis; expressed in all types of spermatogonia (PubMed:9828124, PubMed:18816836). Also expressed in the prostate of neonatal mice (PubMed:18816836). Abnormal glucose tolerance predominantly due to defective glucose-stimulated insulin secretion (PubMed:16024793). Mice also show defects in prostate ductal morphogenesis and secretory protein expression (PubMed:18816836). Belongs to the fem-1 family. epithelial cell maturation ubiquitin-protein transferase activity death receptor binding protein binding nucleus nucleoplasm cytoplasm cytosol apoptotic process protein ubiquitination regulation of ubiquitin-protein transferase activity branching involved in prostate gland morphogenesis epithelial cell maturation involved in prostate gland development regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of DNA damage checkpoint uc009qam.1 uc009qam.2 uc009qam.3 uc009qam.4 uc009qam.5 uc009qam.6 
ENSMUST00000034776.13 Cln6 ENSMUST00000034776.13 ceroid-lipofuscinosis, neuronal 6 (from RefSeq NM_001033175.3) Cln6 ENSMUST00000034776.1 ENSMUST00000034776.10 ENSMUST00000034776.11 ENSMUST00000034776.12 ENSMUST00000034776.2 ENSMUST00000034776.3 ENSMUST00000034776.4 ENSMUST00000034776.5 ENSMUST00000034776.6 ENSMUST00000034776.7 ENSMUST00000034776.8 ENSMUST00000034776.9 NM_001033175 Q3U466 Q3U466_MOUSE uc009qan.1 uc009qan.2 uc009qan.3 ganglioside metabolic process endoplasmic reticulum endoplasmic reticulum lumen lysosome organization lysosomal lumen acidification visual perception cholesterol metabolic process membrane integral component of membrane glycosaminoglycan metabolic process locomotion involved in locomotory behavior protein homodimerization activity cellular macromolecule catabolic process positive regulation of proteolysis uc009qan.1 uc009qan.2 uc009qan.3 
ENSMUST00000034777.14 Calml4 ENSMUST00000034777.14 calmodulin-like 4, transcript variant 1 (from RefSeq NM_138304.2) CALL4_MOUSE ENSMUST00000034777.1 ENSMUST00000034777.10 ENSMUST00000034777.11 ENSMUST00000034777.12 ENSMUST00000034777.13 ENSMUST00000034777.2 ENSMUST00000034777.3 ENSMUST00000034777.4 ENSMUST00000034777.5 ENSMUST00000034777.6 ENSMUST00000034777.7 ENSMUST00000034777.8 ENSMUST00000034777.9 NM_138304 Q3UJ19 Q8C1Q0 Q8R1P1 Q8VD39 Q91WQ9 uc009qap.1 uc009qap.2 uc009qap.3 uc009qap.4 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q91WQ9-1; Sequence=Displayed; Name=2; IsoId=Q91WQ9-2; Sequence=VSP_030438; Name=3; IsoId=Q91WQ9-3; Sequence=VSP_030437; Belongs to the calmodulin family. calcium ion binding calcium-mediated signaling uc009qap.1 uc009qap.2 uc009qap.3 uc009qap.4 
ENSMUST00000034787.12 Phip ENSMUST00000034787.12 pleckstrin homology domain interacting protein (from RefSeq NM_001081216.1) ENSMUST00000034787.1 ENSMUST00000034787.10 ENSMUST00000034787.11 ENSMUST00000034787.2 ENSMUST00000034787.3 ENSMUST00000034787.4 ENSMUST00000034787.5 ENSMUST00000034787.6 ENSMUST00000034787.7 ENSMUST00000034787.8 ENSMUST00000034787.9 F8VQ93 F8VQ93_MOUSE NM_001081216 Phip uc009qvv.1 uc009qvv.2 uc009qvv.3 insulin receptor binding cytoskeleton organization insulin receptor signaling pathway regulation of cell morphogenesis positive regulation of transcription from RNA polymerase II promoter lysine-acetylated histone binding negative regulation of extrinsic apoptotic signaling pathway uc009qvv.1 uc009qvv.2 uc009qvv.3 
ENSMUST00000034792.7 Ankk1 ENSMUST00000034792.7 ankyrin repeat and kinase domain containing 1, transcript variant 2 (from RefSeq NM_172922.4) ANKK1_MOUSE ENSMUST00000034792.1 ENSMUST00000034792.2 ENSMUST00000034792.3 ENSMUST00000034792.4 ENSMUST00000034792.5 ENSMUST00000034792.6 NM_172922 Q8BZ25 uc009pjb.1 uc009pjb.2 uc009pjb.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation regulation of cell cycle process kinase activity phosphorylation transferase activity cell projection uc009pjb.1 uc009pjb.2 uc009pjb.3 
ENSMUST00000034793.15 Lca5 ENSMUST00000034793.15 Leber congenital amaurosis 5 (human), transcript variant 1 (from RefSeq NM_029434.3) ENSMUST00000034793.1 ENSMUST00000034793.10 ENSMUST00000034793.11 ENSMUST00000034793.12 ENSMUST00000034793.13 ENSMUST00000034793.14 ENSMUST00000034793.2 ENSMUST00000034793.3 ENSMUST00000034793.4 ENSMUST00000034793.5 ENSMUST00000034793.6 ENSMUST00000034793.7 ENSMUST00000034793.8 ENSMUST00000034793.9 G5E887 G5E887_MOUSE Lca5 NM_029434 uc009qwg.1 uc009qwg.2 uc009qwg.3 uc009qwg.4 Belongs to the LCA5 family. uc009qwg.1 uc009qwg.2 uc009qwg.3 uc009qwg.4 
ENSMUST00000034796.14 Elovl4 ENSMUST00000034796.14 ELOVL fatty acid elongase 4 (from RefSeq NM_148941.2) ELOV4_MOUSE ENSMUST00000034796.1 ENSMUST00000034796.10 ENSMUST00000034796.11 ENSMUST00000034796.12 ENSMUST00000034796.13 ENSMUST00000034796.2 ENSMUST00000034796.3 ENSMUST00000034796.4 ENSMUST00000034796.5 ENSMUST00000034796.6 ENSMUST00000034796.7 ENSMUST00000034796.8 ENSMUST00000034796.9 Elovl4 NM_148941 Q8JZV3 Q9EQC4 uc012gxk.1 uc012gxk.2 uc012gxk.3 Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long- chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=2.3.1.199; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32728; Evidence=; Reaction=H(+) + hexacosanoyl-CoA + malonyl-CoA = 3-oxooctacosanyol-CoA + CO2 + CoA; Xref=Rhea:RHEA:36519, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64868, ChEBI:CHEBI:73976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36520; Evidence=; Reaction=H(+) + malonyl-CoA + octacosanoyl-CoA = 3-oxo-triacontanoyl- CoA + CO2 + CoA; Xref=Rhea:RHEA:36807, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74141, ChEBI:CHEBI:74228; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36808; Evidence=; Reaction=H(+) + malonyl-CoA + triacontanoyl-CoA = 3-oxo- dotriacontanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:43852, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:76386, ChEBI:CHEBI:83795; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43853; Evidence=; Reaction=(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36871, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74260, ChEBI:CHEBI:74261; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36872; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl- CoA = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36943, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74298, ChEBI:CHEBI:74304; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36944; Evidence=; Reaction=(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36479, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:73856, ChEBI:CHEBI:73857; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36480; Evidence=; Reaction=(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl- CoA = 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36819, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74229, ChEBI:CHEBI:74230; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36820; Evidence=; Reaction=(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl- CoA = 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36843, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74233, ChEBI:CHEBI:74246; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36844; Evidence=; Reaction=(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36851, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74247, ChEBI:CHEBI:74254; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36852; Evidence=; Reaction=(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl- CoA + CO2 + CoA; Xref=Rhea:RHEA:36859, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74249, ChEBI:CHEBI:74259; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36860; Evidence=; Reaction=(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36875, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74262, ChEBI:CHEBI:74263; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36876; Evidence=; Reaction=(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA = (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36907, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74282, ChEBI:CHEBI:74283; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36908; Evidence=; Reaction=(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36911, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74285, ChEBI:CHEBI:74286; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36912; Evidence=; Reaction=(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36915, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74287, ChEBI:CHEBI:74288; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36916; Evidence=; Reaction=(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl- CoA = 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36919, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74289, ChEBI:CHEBI:74290; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36920; Evidence=; Reaction=(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36923, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74291, ChEBI:CHEBI:74292; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36924; Evidence=; Reaction=(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36927, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74293, ChEBI:CHEBI:74294; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36928; Evidence=; Reaction=(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36947, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74086, ChEBI:CHEBI:74305; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36948; Evidence=; Reaction=(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36963, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74306, ChEBI:CHEBI:74311; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36964; Evidence=; Reaction=(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36967, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74312, ChEBI:CHEBI:74313; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36968; Evidence=; Reaction=(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl- CoA + CO2 + CoA; Xref=Rhea:RHEA:36979, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74315, ChEBI:CHEBI:74316; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36980; Evidence=; Reaction=(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)- tetratriacontahexaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36983, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74317, ChEBI:CHEBI:74318; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36984; Evidence=; Reaction=(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl- CoA + CO2 + CoA; Xref=Rhea:RHEA:36995, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74319, ChEBI:CHEBI:74320; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36996; Evidence=; Reaction=(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl- CoA = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:37243, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74083, ChEBI:CHEBI:74663; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37244; Evidence=; Lipid metabolism; fatty acid biosynthesis. Oligomer. Endoplasmic reticulum membrane ulti-pass membrane protein Expressed in the retina, exclusively in photoreceptor cells and in the brain, skin, testis and lens. Expressed in the ocular tissues of the retina at 10.5 dpc and becomes restricted predominantly to the photoreceptor layer in the mature retina (at protein level). Expressed in the embryo at 7 dpc. The C-terminal di-lysine motif confers endoplasmic reticulum localization. N-glycosylated. Rod or cone-specific conditional knockout of Elovl4 results in a decrease in very long chain (C30-C34) polyunsaturated fatty acids in the retina, but has no effect on photoreceptors survival, phototransduction, synaptic transmission or visual behavior. Belongs to the ELO family. ELOVL4 subfamily. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process fatty acid elongase activity membrane integral component of membrane transferase activity fatty acid elongation, saturated fatty acid sphingolipid biosynthetic process integral component of endoplasmic reticulum membrane fatty acid elongation, monounsaturated fatty acid fatty acid elongation, polyunsaturated fatty acid long-chain fatty-acyl-CoA biosynthetic process very long-chain fatty acid biosynthetic process 3-oxo-arachidoyl-CoA synthase activity 3-oxo-cerotoyl-CoA synthase activity 3-oxo-lignoceronyl-CoA synthase activity uc012gxk.1 uc012gxk.2 uc012gxk.3 
ENSMUST00000034803.10 Zw10 ENSMUST00000034803.10 zw10 kinetochore protein (from RefSeq NM_012039.2) ENSMUST00000034803.1 ENSMUST00000034803.2 ENSMUST00000034803.3 ENSMUST00000034803.4 ENSMUST00000034803.5 ENSMUST00000034803.6 ENSMUST00000034803.7 ENSMUST00000034803.8 ENSMUST00000034803.9 NM_012039 O54692 Q3TIA5 Q3ULW1 Q921H3 ZW10_MOUSE uc009piu.1 uc009piu.2 uc009piu.3 uc009piu.4 Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (By similarity). Interacts with NBAS and KNTC1/ROD; the interactions are mutually exclusive and indicative for its association in two different vesicle tethering complexes (By similarity). Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH (By similarity). Component of the NRZ complex composed of NBAS, ZW10 and RINT1/TIP20L; NRZ associates with SNAREs STX18, USE1L, BNIP1/SEC20L and SEC22B (the assembly has been described as syntaxin 18 complex) (By similarity). Interacts directly with RINT1/TIP20L bound to BNIP1/SEC20L (By similarity). Interacts with C19orf25 and ZWINT (By similarity). Interacts with ZFYVE1 (By similarity). Interacts with RAB18 and this interaction is enhanced in the presence of ZFYVE1 (By similarity). Cytoplasm Endoplasmic reticulum membrane ; Peripheral membrane protein Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Lipid droplet Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone. Belongs to the ZW10 family. mitotic sister chromatid segregation establishment of mitotic spindle orientation mitotic cell cycle chromosome, centromeric region kinetochore condensed chromosome kinetochore spindle pole nucleus chromosome cytoplasm endoplasmic reticulum endoplasmic reticulum membrane spindle kinetochore microtubule cytosol cytoskeleton ER to Golgi vesicle-mediated transport Golgi organization cell cycle mitotic metaphase plate congression mitotic cell cycle checkpoint mitotic spindle assembly checkpoint regulation of exit from mitosis protein transport membrane vesicle-mediated transport protein localization to kinetochore cell division macromolecular complex assembly Dsl1/NZR complex RZZ complex uc009piu.1 uc009piu.2 uc009piu.3 uc009piu.4 
ENSMUST00000034808.12 Nnmt ENSMUST00000034808.12 nicotinamide N-methyltransferase, transcript variant 1 (from RefSeq NM_010924.4) ENSMUST00000034808.1 ENSMUST00000034808.10 ENSMUST00000034808.11 ENSMUST00000034808.2 ENSMUST00000034808.3 ENSMUST00000034808.4 ENSMUST00000034808.5 ENSMUST00000034808.6 ENSMUST00000034808.7 ENSMUST00000034808.8 ENSMUST00000034808.9 NM_010924 NNMT_MOUSE O55239 uc009pik.1 uc009pik.2 uc009pik.3 uc009pik.4 Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1- methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:26168293, PubMed:29483571). Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases (By similarity). Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (By similarity). Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis (PubMed:24717514, PubMed:26168293). In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (PubMed:24717514). Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (PubMed:26168293). Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (By similarity). Reaction=nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:23884, ChEBI:CHEBI:16797, ChEBI:CHEBI:17154, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23885; Evidence=; Inhibited by 6-methoxynicotinamide (JBSNF-000088). Cofactor metabolism. Amino-acid degradation. Monomer. Cytoplasm. Expressed in white adipose tissue and liver (at protein level). Up-regulated in white adipose tissue and liver in response to high-fat diet. Deiminated by PADI1 and PADI2. Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. cytoplasm cytosol nicotinamide N-methyltransferase activity methyltransferase activity response to organonitrogen compound transferase activity animal organ regeneration methylation response to drug uc009pik.1 uc009pik.2 uc009pik.3 uc009pik.4 
ENSMUST00000034811.8 Cyp19a1 ENSMUST00000034811.8 cytochrome P450, family 19, subfamily a, polypeptide 1, transcript variant 1 (from RefSeq NM_007810.4) Cyp19a1 ENSMUST00000034811.1 ENSMUST00000034811.2 ENSMUST00000034811.3 ENSMUST00000034811.4 ENSMUST00000034811.5 ENSMUST00000034811.6 ENSMUST00000034811.7 NM_007810 Q3ZAT3 Q3ZAT3_MOUSE uc009pmu.1 uc009pmu.2 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding endoplasmic reticulum androgen catabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process aromatase activity positive regulation of estradiol secretion uc009pmu.1 uc009pmu.2 
ENSMUST00000034815.9 Kif23 ENSMUST00000034815.9 kinesin family member 23, transcript variant 2 (from RefSeq NM_024245.5) E9Q5G3 ENSMUST00000034815.1 ENSMUST00000034815.2 ENSMUST00000034815.3 ENSMUST00000034815.4 ENSMUST00000034815.5 ENSMUST00000034815.6 ENSMUST00000034815.7 ENSMUST00000034815.8 KIF23_MOUSE NM_024245 Q80V30 Q99PT8 uc009pzu.1 uc009pzu.2 uc009pzu.3 uc009pzu.4 uc009pzu.5 Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro (By similarity). Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY (By similarity). Interacts with ARF6, forming heterodimers and heterotetramers. Nucleus Cytoplasm, cytoskeleton, spindle Midbody, Midbody ring Note=Localizes to the interzone of mitotic spindles (By similarity). Detected at the midbody during later stages of mitotic cytokinesis. Detected in testis and ovary from newborn mice (at protein level). Detected in brain, spinal cord and small intestine. Ubiquitinated. Deubiquitinated by USP8/UBPY (By similarity). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding mitotic cytokinesis actomyosin contractile ring assembly microtubule motor activity ATP binding nucleus nucleoplasm cytoplasm centrosome spindle cytoskeleton kinesin complex microtubule microtubule-based movement cell cycle microtubule binding ATPase activity midbody positive regulation of cytokinesis intercellular bridge mitotic spindle midzone assembly cell division plus-end-directed vesicle transport along microtubule mitotic spindle Flemming body centralspindlin complex uc009pzu.1 uc009pzu.2 uc009pzu.3 uc009pzu.4 uc009pzu.5 
ENSMUST00000034817.11 Paqr5 ENSMUST00000034817.11 progestin and adipoQ receptor family member V, transcript variant 5 (from RefSeq NR_184645.1) ENSMUST00000034817.1 ENSMUST00000034817.10 ENSMUST00000034817.2 ENSMUST00000034817.3 ENSMUST00000034817.4 ENSMUST00000034817.5 ENSMUST00000034817.6 ENSMUST00000034817.7 ENSMUST00000034817.8 ENSMUST00000034817.9 Mprg NR_184645 PAQR5_MOUSE Paqr5 Q7TPQ5 Q8C6Z8 Q9DCU0 uc009qaa.1 uc009qaa.2 uc009qaa.3 Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Cell membrane ; Multi-pass membrane protein Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). Belongs to the ADIPOR family. Sequence=AAH54855.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC35142.1; Type=Erroneous initiation; Evidence=; steroid binding plasma membrane multicellular organism development lipid binding membrane integral component of membrane cell differentiation signaling receptor activity oogenesis uc009qaa.1 uc009qaa.2 uc009qaa.3 
ENSMUST00000034822.12 Acsbg1 ENSMUST00000034822.12 acyl-CoA synthetase bubblegum family member 1 (from RefSeq NM_053178.2) ACBG1_MOUSE Acsbg1 ENSMUST00000034822.1 ENSMUST00000034822.10 ENSMUST00000034822.11 ENSMUST00000034822.2 ENSMUST00000034822.3 ENSMUST00000034822.4 ENSMUST00000034822.5 ENSMUST00000034822.6 ENSMUST00000034822.7 ENSMUST00000034822.8 ENSMUST00000034822.9 Kiaa0631 Lpd NM_053178 Q6ZQ79 Q99PU5 uc009prj.1 uc009prj.2 uc009prj.3 Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity) (PubMed:11112418, PubMed:12975357, PubMed:14516277). Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:11112418, PubMed:14516277). Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl- CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence=; Reaction=(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:36139, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61526, ChEBI:CHEBI:72745, ChEBI:CHEBI:456215; Evidence=; Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl- CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:456215; Evidence=; Cytoplasm Cytoplasmic vesicle. Microsome. Endoplasmic reticulum Cell membrane Mainly expressed in brain. Also expressed in adrenal gland and testis. In brain, it is present in cerebral cortical and cerebellar neurons and in steroidogenic cells of the adrenal gland, testis and ovary (at protein level). First detected on embryonic day 18 and increases steadily towards adulthood. Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. Sequence=BAC97989.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; very long-chain fatty acid metabolic process nucleotide binding long-chain fatty acid metabolic process catalytic activity acyl-CoA ligase activity long-chain fatty acid-CoA ligase activity ATP binding cytoplasm endoplasmic reticulum plasma membrane lipid metabolic process fatty acid metabolic process membrane ligase activity cytoplasmic vesicle very long-chain fatty acid-CoA ligase activity long-chain fatty acid biosynthetic process intracellular membrane-bounded organelle response to glucocorticoid decanoate--CoA ligase activity peroxisome Golgi apparatus uc009prj.1 uc009prj.2 uc009prj.3 
ENSMUST00000034827.10 Imp3 ENSMUST00000034827.10 IMP3, U3 small nucleolar ribonucleoprotein (from RefSeq NM_133976.2) ENSMUST00000034827.1 ENSMUST00000034827.2 ENSMUST00000034827.3 ENSMUST00000034827.4 ENSMUST00000034827.5 ENSMUST00000034827.6 ENSMUST00000034827.7 ENSMUST00000034827.8 ENSMUST00000034827.9 IMP3_MOUSE NM_133976 Q921Y2 uc009ptq.1 uc009ptq.2 uc009ptq.3 Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10. Nucleus, nucleolus Belongs to the universal ribosomal protein uS4 family. RNA binding nucleus nucleolus rRNA processing rRNA binding snoRNA binding preribosome small-subunit processome Mpp10 complex ribosome biogenesis uc009ptq.1 uc009ptq.2 uc009ptq.3 
ENSMUST00000034830.9 Crabp1 ENSMUST00000034830.9 cellular retinoic acid binding protein I, transcript variant 1 (from RefSeq NM_013496.3) ENSMUST00000034830.1 ENSMUST00000034830.2 ENSMUST00000034830.3 ENSMUST00000034830.4 ENSMUST00000034830.5 ENSMUST00000034830.6 ENSMUST00000034830.7 ENSMUST00000034830.8 NM_013496 P02695 P02697 P15780 P62965 Q3UN78 RABP1_MOUSE uc009prp.1 uc009prp.2 uc009prp.3 Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. Cytoplasm. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. retinoic acid binding retinoid binding cytoplasm cytosol lipid binding retinal binding retinol binding retinoic acid catabolic process uc009prp.1 uc009prp.2 uc009prp.3 
ENSMUST00000034831.3 Nr2e3 ENSMUST00000034831.3 nuclear receptor subfamily 2, group E, member 3 (from RefSeq NM_013708.4) ENSMUST00000034831.1 ENSMUST00000034831.2 NM_013708 NR2E3_MOUSE Pnr Q9QXZ7 Rnr uc009pyu.1 uc009pyu.2 uc009pyu.3 Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. Homodimer. Interacts with PIAS3; the interaction sumoylates NR2E3 and promotes repression of cone-specific gene transcription and activation of rod-specific genes. Component of a rod photoreceptor complex that includes NR2E3, PIAS3, NRL, CRX and/or NR1D1. Binds directly in the complex with CRX, PIAS3 and NR1D1 (By similarity). Interacts (via the DNA-binding domain) with CRX (via its DNA binding domain); the interaction represses S- and M-cone opsin expression. Nucleus Retina. Rod-specific. Expressed in the outer nuclear lyer of the mature retina. Expression found as early as 18 dpc in developing retina. From P3 to P6, expression increases in developing rods. Expression, thereafter, in the future inner nuclear layer migrating to the final destination of the outer nuclear layer. In the mature retina, exclusively expressed in rods. Di- and tri-sumoylated in developing retina. PIAS3-mediated sumoylation promotes repression of cone-specific gene expression and activation of rod-specific genes. Sumoylation on Lys-178 appears to be the main site. Defects in Nr2e3 are the cause of the retinal degeneration type 7 (Rd7) phenotype characterized by excessive blue cones and loss of rods. Belongs to the nuclear hormone receptor family. NR2 subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity protein binding nucleus transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter zinc ion binding negative regulation of cell proliferation cell differentiation eye photoreceptor cell development steroid hormone mediated signaling pathway sequence-specific DNA binding positive regulation of rhodopsin gene expression positive regulation of transcription from RNA polymerase II promoter metal ion binding anatomical structure development retina development in camera-type eye uc009pyu.1 uc009pyu.2 uc009pyu.3 
ENSMUST00000034832.8 Ptpn9 ENSMUST00000034832.8 protein tyrosine phosphatase, non-receptor type 9 (from RefSeq NM_019651.2) ENSMUST00000034832.1 ENSMUST00000034832.2 ENSMUST00000034832.3 ENSMUST00000034832.4 ENSMUST00000034832.5 ENSMUST00000034832.6 ENSMUST00000034832.7 NM_019651 Ptpn9 Q2M4G8 Q2M4G8_MOUSE uc009ptt.1 uc009ptt.2 uc009ptt.3 uc009ptt.4 phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytoplasm protein dephosphorylation negative regulation of neuron projection development dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation neuron projection terminus positive regulation of protein localization to plasma membrane uc009ptt.1 uc009ptt.2 uc009ptt.3 uc009ptt.4 
ENSMUST00000034834.16 Pkm ENSMUST00000034834.16 pyruvate kinase, muscle, transcript variant 2 (from RefSeq NM_011099.4) ENSMUST00000034834.1 ENSMUST00000034834.10 ENSMUST00000034834.11 ENSMUST00000034834.12 ENSMUST00000034834.13 ENSMUST00000034834.14 ENSMUST00000034834.15 ENSMUST00000034834.2 ENSMUST00000034834.3 ENSMUST00000034834.4 ENSMUST00000034834.5 ENSMUST00000034834.6 ENSMUST00000034834.7 ENSMUST00000034834.8 ENSMUST00000034834.9 KPYM_MOUSE NM_011099 P52480 Pk3 Pkm2 Pykm Q3TBV8 Q3TBW5 Q3TC59 Q3U1X3 Q3U5P6 Q4VC20 Q64484 Q91YI8 Q9CWB1 uc009pyi.1 uc009pyi.2 uc009pyi.3 Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (By similarity). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (By similarity). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (By similarity). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (By similarity). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (By similarity). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (PubMed:29996098). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (PubMed:28575669). Plays a role in caspase independent cell death of tumor cells (By similarity). [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth. In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity. [Isoform M2]: Reaction=ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate; Xref=Rhea:RHEA:18157, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58702, ChEBI:CHEBI:456216; EC=2.7.1.40; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18159; Evidence=; [Isoform M1]: Reaction=ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate; Xref=Rhea:RHEA:18157, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58702, ChEBI:CHEBI:456216; EC=2.7.1.40; Evidence=; [Isoform M2]: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10597; Evidence=; [Isoform M2]: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence=; [Isoform M2]: Isoform M2 is allosterically activated by D-fructose 1,6-bisphosphate (FBP). Inhibited by oxalate and 3,3',5-triiodo-L-thyronine (T3). The activity of the tetrameric form is inhibited by PML. Selective binding to tyrosine-phosphorylated peptides releases the allosteric activator FBP, leading to inhibition of PKM enzymatic activity, this diverts glucose metabolites from energy production to anabolic processes when cells are stimulated by certain growth factors. Glycolytic flux are highly dependent on de novo biosynthesis of serine and glycine, and serine is a natural ligand and allosteric activator of isoform M2. Acetylation at Lys-433 promotes its translocation into the nucleus and homodimerization, promoting the protein kinase activity. [Isoform M1]: Has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6- bisphosphate (FBP) for activity. Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 5/5. [Isoform M2]: Monomer and homotetramer; exists as a monomer in the absence of D-fructose 1,6-bisphosphate (FBP), and reversibly associates to form a homotetramer in the presence of FBP. The monomeric form binds 3,3',5-triiodo-L-thyronine (T3). Tetramer formation induces pyruvate kinase activity. The tetrameric form has high affinity for the substrate and is associated within the glycolytic enzyme complex. FBP stimulates the formation of tetramers from dimers. Homodimer; exists in a dimeric form in tumor cells and the dimeric form has less affinity for the phosphoenolpyruvate substrate. The homodimer converts into a protein kinase. Interacts with HERC1, POU5F1 and PML. Interacts with EGLN3; the interaction hydroxylates PKM under hypoxia and enhances binding to HIF1A. Interacts with HIF1A; the interaction is enhanced by binding of EGLN3, promoting enhanced transcription activity under hypoxia. Interacts with TRIM35; this interaction prevents FGFR1- dependent tyrosine phosphorylation. Interacts with JMJD8. Interacts with TRAF4. Interacts with (phosphorylated) CTNNB1; leading to activate transcription. Interacts with TSC22D2; the interaction results in reduced nuclear levels of PKM isoform M2, leading to repression of cyclin CCND1 transcription and reduced cell growth (By similarity). P52480; P20263: Pou5f1; NbExp=6; IntAct=EBI-647785, EBI-1606219; P52480; PRO_0000025675 [P04156]: PRNP; Xeno; NbExp=5; IntAct=EBI-647785, EBI-8830282; P52480; P26663; Xeno; NbExp=3; IntAct=EBI-647785, EBI-6857429; [Isoform M2]: Cytoplasm Nucleus Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli. Nuclear translocation is promoted by acetylation by EP300. Deacetylation by SIRT6 promotes its nuclear export in a process dependent of XPO4, thereby suppressing its ability to activate transcription and promote tumorigenesis. [Isoform M1]: Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=M2 ; Synonyms=PKM2 ; IsoId=P52480-1; Sequence=Displayed; Name=M1 ; Synonyms=PKM1 ; IsoId=P52480-2; Sequence=VSP_025057; Embryonic stem cells and embryonal carcinoma cells. ISGylated. Under hypoxia, hydroxylated by EGLN3. Acetylation at Lys-305 is stimulated by high glucose concentration, it decreases enzyme activity and promotes its lysosomal- dependent degradation via chaperone-mediated autophagy. [Isoform M2]: Acetylated at Lys-433 by EP300, leading to impair phosphoenolpyruvate substrate-binding and promote its homodimerization and subsequent translocation to the nucleus. Deacetylation at Lys-433 by SIRT6 promotes its nuclear export into the cytoplasm, leading to suppress its nuclear localization and oncogenic function. FGFR1-dependent tyrosine phosphorylation is reduced by interaction with TRIM35. Myeloid-cell-specific BMAL1 and PKM2 double knockout reduces the risk of sepsis lethality which is associated with reduced serum lactate levels and reduced CD274 expression in macrophages. There are 4 isozymes of pyruvate kinase in mammals (L, R, M1, M2) encoded by 2 different genes: PKLR and PKM. The L and R isozymes are generated from the PKLR by differential splicing of RNA; the M1 and M2 forms are produced from the PKM gene by differential splicing. L type is major isozyme in the liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues as well as in most cancer cells. Belongs to the pyruvate kinase family. nucleotide binding magnesium ion binding liver development photoreceptor inner segment catalytic activity pyruvate kinase activity protein binding ATP binding nucleus cytoplasm mitochondrion cytosol cilium glucose metabolic process glycolytic process ATP biosynthetic process metabolic process programmed cell death kinase activity phosphorylation transferase activity potassium ion binding animal organ regeneration cellular response to insulin stimulus identical protein binding pyruvate biosynthetic process myelin sheath skeletal muscle tissue regeneration ADP binding metal ion binding protein homotetramerization thyroid hormone binding pyruvate kinase complex positive regulation of sprouting angiogenesis uc009pyi.1 uc009pyi.2 uc009pyi.3 
ENSMUST00000034843.9 Ireb2 ENSMUST00000034843.9 iron responsive element binding protein 2, transcript variant 1 (from RefSeq NM_022655.4) E9QPM2 ENSMUST00000034843.1 ENSMUST00000034843.2 ENSMUST00000034843.3 ENSMUST00000034843.4 ENSMUST00000034843.5 ENSMUST00000034843.6 ENSMUST00000034843.7 ENSMUST00000034843.8 IREB2_MOUSE Irp2 NM_022655 O70235 Q811J3 uc009prq.1 uc009prq.2 uc009prq.3 uc009prq.4 RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster per subunit. [4Fe-4S]-binding affects RNA-binding activity, thereby inhibiting activity of the protein. ; Interacts with RBCK1 only in iron-rich conditions. Interacts (when associated with the 4Fe-4S) with FBXL5 (By similarity). Interacts with CIAO1 and CIAO2A (PubMed:23891004). Cytoplasm Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its RNA-binding activity (By similarity). Belongs to the aconitase/IPM isomerase family. regulatory region RNA binding RNA binding aconitate hydratase activity cytoplasm mitochondrion endoplasmic reticulum Golgi apparatus cytosol tricarboxylic acid cycle citrate metabolic process regulation of translation protoporphyrinogen IX biosynthetic process cellular iron ion homeostasis post-embryonic development response to iron(III) ion regulation of gene expression negative regulation of translation osteoclast differentiation iron-responsive element binding translation repressor activity axon erythrocyte homeostasis neuronal cell body metal ion binding intestinal absorption iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding iron ion homeostasis cellular response to iron(III) ion cellular response to manganese ion cellular response to epidermal growth factor stimulus cellular response to mercaptoethanol cellular response to oxygen-glucose deprivation uc009prq.1 uc009prq.2 uc009prq.3 uc009prq.4 
ENSMUST00000034846.7 1700017B05Rik ENSMUST00000034846.7 RIKEN cDNA 1700017B05 gene (from RefSeq NM_028820.2) CO039_MOUSE ENSMUST00000034846.1 ENSMUST00000034846.2 ENSMUST00000034846.3 ENSMUST00000034846.4 ENSMUST00000034846.5 ENSMUST00000034846.6 NM_028820 Q148A1 Q3TEI4 Q3TMF2 Q3U253 Q3UM75 Q9DA93 uc009puq.1 uc009puq.2 uc009puq.3 uc009puq.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TEI4-1; Sequence=Displayed; Name=2; IsoId=Q3TEI4-2; Sequence=VSP_019542; [Isoform 2]: May be due to competing donor splice site. molecular_function cytosol biological_process uc009puq.1 uc009puq.2 uc009puq.3 uc009puq.4 
ENSMUST00000034848.14 Psma4 ENSMUST00000034848.14 proteasome subunit alpha 4, transcript variant 1 (from RefSeq NM_011966.4) ENSMUST00000034848.1 ENSMUST00000034848.10 ENSMUST00000034848.11 ENSMUST00000034848.12 ENSMUST00000034848.13 ENSMUST00000034848.2 ENSMUST00000034848.3 ENSMUST00000034848.4 ENSMUST00000034848.5 ENSMUST00000034848.6 ENSMUST00000034848.7 ENSMUST00000034848.8 ENSMUST00000034848.9 NM_011966 PSA4_MOUSE Q3THT1 Q9R1P0 uc009pru.1 uc009pru.2 uc009pru.3 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:16857966, PubMed:22341445). Cytoplasm Nucleus Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (By similarity). Colocalizes with TRIM5 in the cytoplasmic bodies (PubMed:22078707). Detected in liver (at protein level). Belongs to the peptidase T1A family. proteasome complex P-body endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteolysis ubiquitin-dependent protein catabolic process peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, alpha-subunit complex proteasome-mediated ubiquitin-dependent protein catabolic process intracellular membrane-bounded organelle proteolysis involved in cellular protein catabolic process uc009pru.1 uc009pru.2 uc009pru.3 
ENSMUST00000034851.7 Chrna3 ENSMUST00000034851.7 cholinergic receptor, nicotinic, alpha polypeptide 3 (from RefSeq NM_145129.3) ACHA3_MOUSE ENSMUST00000034851.1 ENSMUST00000034851.2 ENSMUST00000034851.3 ENSMUST00000034851.4 ENSMUST00000034851.5 ENSMUST00000034851.6 NM_145129 Q8BV44 Q8R4G9 uc009prx.1 uc009prx.2 uc009prx.3 uc009prx.4 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Part of a complex composed of STUB1/CHIP, VCP/p97, CHRNA3, and UBXN2A that modulates the ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of CHRNA3 (By similarity). Within the complex UBXN2A acts as a scaffold protein required for the interaction of CHRNA3 with VCP/p97, this interaction also inhibits CHRNA3 ubiquitination by STUB1/CHIP and subsequently ERAD (By similarity). Interacts with UBXN2A (via SEP domain), the interaction is required for the interaction of CHRNA3 in the STUB1-VCP-UBXN2A complex (PubMed:19474315). Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6. The heteropentamer alpha-3-beta-2 interacts with alpha- conotoxins ImI, ImII, PnIA, GID and MII. The heteropentamer alpha-3- beta-4 interacts with the alpha-conotoxin ImI. Postsynaptic cell membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum Golgi apparatus Note=Interaction with UBXN2A/UBXD4 promotes translocation to the plasma membrane. Expressed in the brain (at protein level). Ubiquitinated; by STUB1/CHIP and thereafter degraded by the 26S proteosome complex. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub- subfamily. Sequence=BAC37909.1; Type=Erroneous initiation; Evidence=; transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity protein binding plasma membrane integral component of plasma membrane acetylcholine-gated channel complex ion transport regulation of muscle contraction regulation of smooth muscle contraction signal transduction activation of transmembrane receptor protein tyrosine kinase activity chemical synaptic transmission synaptic transmission, cholinergic neuromuscular synaptic transmission nervous system development locomotory behavior drug binding regulation of acetylcholine secretion, neurotransmission postsynaptic density acetylcholine receptor activity membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction dendrite ion transmembrane transport response to nicotine behavioral response to nicotine acetylcholine binding regulation of membrane potential response to drug neuron projection neuronal cell body plasma membrane raft synapse postsynaptic membrane protein heterodimerization activity regulation of dendrite morphogenesis neurological system process protein heterooligomerization excitatory postsynaptic potential synaptic transmission involved in micturition acetylcholine receptor signaling pathway cholinergic synapse integral component of postsynaptic specialization membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential response to acetylcholine regulation of synaptic vesicle exocytosis uc009prx.1 uc009prx.2 uc009prx.3 uc009prx.4 
ENSMUST00000034854.8 Chrnb4 ENSMUST00000034854.8 cholinergic receptor, nicotinic, beta polypeptide 4 (from RefSeq NM_148944.4) ACHB4_MOUSE Acrb4 ENSMUST00000034854.1 ENSMUST00000034854.2 ENSMUST00000034854.3 ENSMUST00000034854.4 ENSMUST00000034854.5 ENSMUST00000034854.6 ENSMUST00000034854.7 NM_148944 Q8R493 Q8VI06 uc009psa.1 uc009psa.2 uc009psa.3 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6. The pentamer alpha3-beta-4 interacts with the conotoxin BuIA. The heteropentamer composed of alpha-3 and beta-4 subunits interacts with the alpha-conotoxin ImI (By similarity). Postsynaptic cell membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Predominantly expressed by immature T-cells in the thymus. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub- subfamily. action potential transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane integral component of plasma membrane acetylcholine-gated channel complex ion transport smooth muscle contraction regulation of smooth muscle contraction signal transduction chemical synaptic transmission synaptic transmission, cholinergic neuromuscular synaptic transmission locomotory behavior drug binding acetylcholine receptor activity membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction ion transmembrane transport response to nicotine behavioral response to nicotine acetylcholine binding regulation of membrane potential neuron projection synapse postsynaptic membrane protein heterodimerization activity neurological system process protein heterooligomerization positive regulation of transmission of nerve impulse regulation of postsynaptic membrane potential excitatory postsynaptic potential synaptic transmission involved in micturition cholinergic synapse transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc009psa.1 uc009psa.2 uc009psa.3 
ENSMUST00000034856.15 Mpi ENSMUST00000034856.15 mannose phosphate isomerase, transcript variant 2 (from RefSeq NR_151692.1) ENSMUST00000034856.1 ENSMUST00000034856.10 ENSMUST00000034856.11 ENSMUST00000034856.12 ENSMUST00000034856.13 ENSMUST00000034856.14 ENSMUST00000034856.2 ENSMUST00000034856.3 ENSMUST00000034856.4 ENSMUST00000034856.5 ENSMUST00000034856.6 ENSMUST00000034856.7 ENSMUST00000034856.8 ENSMUST00000034856.9 MPI_MOUSE Mpi Mpi1 NR_151692 Pmi Q924M7 uc009pvd.1 uc009pvd.2 uc009pvd.3 Isomerase that catalyzes the interconversion of fructose-6-P and mannose-6-P and has a critical role in the supply of D-mannose derivatives required for many eukaryotic glycosylation reactions. Reaction=D-mannose 6-phosphate = D-fructose 6-phosphate; Xref=Rhea:RHEA:12356, ChEBI:CHEBI:58735, ChEBI:CHEBI:61527; EC=5.3.1.8; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2. Cytoplasm Expressed in all tissues, but more abundant in testis. Belongs to the mannose-6-phosphate isomerase type 1 family. cell wall mannoprotein biosynthetic process mannose-6-phosphate isomerase activity cytoplasm cytosol carbohydrate metabolic process protein glycosylation zinc ion binding GDP-mannose biosynthetic process isomerase activity metal ion binding mannose to fructose-6-phosphate metabolic process glycolytic process from mannose through fructose-6-phosphate uc009pvd.1 uc009pvd.2 uc009pvd.3 
ENSMUST00000034859.15 Fbxo22 ENSMUST00000034859.15 F-box protein 22 (from RefSeq NM_028049.2) ENSMUST00000034859.1 ENSMUST00000034859.10 ENSMUST00000034859.11 ENSMUST00000034859.12 ENSMUST00000034859.13 ENSMUST00000034859.14 ENSMUST00000034859.2 ENSMUST00000034859.3 ENSMUST00000034859.4 ENSMUST00000034859.5 ENSMUST00000034859.6 ENSMUST00000034859.7 ENSMUST00000034859.8 ENSMUST00000034859.9 FBX22_MOUSE Fbx22 NM_028049 Q78JE5 uc009psc.1 uc009psc.2 uc009psc.3 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome- dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Directly interacts with SKP1 and CUL1. Cytoplasm, myofibril, sarcomere, Z line Sequence=AAH18273.1; Type=Erroneous initiation; Evidence=; protein polyubiquitination protein binding nucleus cytoplasm nucleocytoplasmic transport cellular response to starvation regulation of myotube differentiation Z disc positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of skeletal muscle fiber development positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc009psc.1 uc009psc.2 uc009psc.3 
ENSMUST00000034860.5 Cyp1a2 ENSMUST00000034860.5 cytochrome P450, family 1, subfamily a, polypeptide 2 (from RefSeq NM_009993.3) CP1A2_MOUSE Cyp1a-2 ENSMUST00000034860.1 ENSMUST00000034860.2 ENSMUST00000034860.3 ENSMUST00000034860.4 NM_009993 P00186 Q9QWJ4 uc009pvm.1 uc009pvm.2 uc009pvm.3 A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25- hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase- like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence=; Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:47212, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:28744, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47213; Evidence=; Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:47280, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62845; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47281; Evidence=; Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2- hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47208, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:1156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47209; Evidence=; Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4- hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47292, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87602; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47293; Evidence=; Reaction=cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50256, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:42977, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50257; Evidence=; Reaction=all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:42092, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42093; Evidence=; Reaction=all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:42088, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42089; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131965; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49861; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49856, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131964; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49857; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)- eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39779, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76634; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39780; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)- docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52120, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136410; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52121; Evidence=; Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo- (6E,8Z,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48632, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:65342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48633; Evidence=; Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo- (5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37947, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37948; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo- (5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48637; Evidence=; Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)- octadecadienoate + H2O; Xref=Rhea:RHEA:48716, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:90781; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48717; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52292, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:136524; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52293; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39759, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76627; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39760; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52284, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:136522; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52285; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Cofactor metabolism; retinol metabolism. Steroid metabolism; cholesterol metabolism. Lipid metabolism; arachidonate metabolism. Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization. Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein By 3-methylcholanthrene (3MC). Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process steroid catabolic process cellular aromatic compound metabolic process porphyrin-containing compound metabolic process steroid metabolic process cholesterol metabolic process estrogen metabolic process toxin biosynthetic process toxin metabolic process post-embryonic development alkaloid metabolic process response to organic substance regulation of gene expression response to organic cyclic compound membrane monoterpenoid metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen lyase activity drug metabolic process dibenzo-p-dioxin metabolic process arachidonic acid metabolic process enzyme binding heme binding lung development organelle membrane response to estradiol demethylase activity response to lipopolysaccharide monocarboxylic acid metabolic process caffeine oxidase activity response to immobilization stress response to drug retinol metabolic process drug catabolic process exogenous drug catabolic process intracellular membrane-bounded organelle cellular respiration heterocycle metabolic process metal ion binding hydrogen peroxide biosynthetic process oxidation-reduction process aromatase activity oxidative demethylation cellular response to cadmium ion cellular response to copper ion oxidative deethylation estrogen 16-alpha-hydroxylase activity estrogen 2-hydroxylase activity uc009pvm.1 uc009pvm.2 uc009pvm.3 
ENSMUST00000034862.5 Tmem266 ENSMUST00000034862.5 transmembrane protein 266, transcript variant 1 (from RefSeq NM_172923.5) B1B1B3 ENSMUST00000034862.1 ENSMUST00000034862.2 ENSMUST00000034862.3 ENSMUST00000034862.4 NM_172923 Q6NVG3 Q8BZB3 TM266_MOUSE Tmem266 uc009psk.1 uc009psk.2 uc009psk.3 Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition. Homodimer; disulfide-linked. Cell membrane ; Multi-pass membrane protein Cell projection, dendrite Perikaryon Note=Present in the dendrites and soma of cerebellar granule neurons, but not in their axon. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZB3-1; Sequence=Displayed; Name=2; IsoId=Q8BZB3-2; Sequence=VSP_022109, VSP_022110, VSP_019514, VSP_019515; In brain, present in the granule layer of the cerebellar cortex (PubMed:25165868). Localizes on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (at protein level) (PubMed:25165868). The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Transplantation of the transmembrane segment S4 into HVCN1, generates a functional voltage-activated proton channel. cytosol plasma membrane integral component of plasma membrane ion transport membrane integral component of membrane dendrite protein homodimerization activity cell projection perikaryon transmembrane transport channel activity voltage-gated channel activity uc009psk.1 uc009psk.2 uc009psk.3 
ENSMUST00000034866.9 Etfa ENSMUST00000034866.9 electron transferring flavoprotein, alpha polypeptide (from RefSeq NM_145615.4) ENSMUST00000034866.1 ENSMUST00000034866.2 ENSMUST00000034866.3 ENSMUST00000034866.4 ENSMUST00000034866.5 ENSMUST00000034866.6 ENSMUST00000034866.7 ENSMUST00000034866.8 ETFA_MOUSE NM_145615 Q3THD7 Q3V000 Q4V9X5 Q8BMD3 Q8BMU7 Q99LC5 uc009psl.1 uc009psl.2 uc009psl.3 uc009psl.4 Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per dimer. ; Heterodimer composed of ETFA and ETFB. Identified in a complex that contains ETFA, ETFB and ETFRF1. Interaction with ETFRF1 promotes dissociation of the bound FAD and loss of electron transfer activity (By similarity). Interacts with TASOR (PubMed:31112734). Mitochondrion matrix Expressed in the spermatogonia, spermatocytes, ovary and granular cells within the cerebellum. Domain I shares an identical polypeptide fold with the beta subunit ETFB though there is no sequence similarity. Belongs to the ETF alpha-subunit/FixB family. protein binding mitochondrion mitochondrial matrix electron carrier activity oxidoreductase activity mitochondrial electron transfer flavoprotein complex electron transport chain fatty acid beta-oxidation using acyl-CoA dehydrogenase flavin adenine dinucleotide binding oxidation-reduction process uc009psl.1 uc009psl.2 uc009psl.3 uc009psl.4 
ENSMUST00000034868.14 Clk1 ENSMUST00000034868.14 CDC-like kinase 1, transcript variant 3 (from RefSeq NR_027854.1) A6H6K2 CLK1_MOUSE Clk Clk1 ENSMUST00000034868.1 ENSMUST00000034868.10 ENSMUST00000034868.11 ENSMUST00000034868.12 ENSMUST00000034868.13 ENSMUST00000034868.2 ENSMUST00000034868.3 ENSMUST00000034868.4 ENSMUST00000034868.5 ENSMUST00000034868.6 ENSMUST00000034868.7 ENSMUST00000034868.8 ENSMUST00000034868.9 NR_027854 P22518 Q3UXB6 Sty uc007bbs.1 uc007bbs.2 uc007bbs.3 uc007bbs.4 Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates (PubMed:1825055, PubMed:1986248, PubMed:9307018). Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 (PubMed:8617202, PubMed:9307018). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10597; Evidence=; Regulates splicing of its own pre-mRNA according to its kinase activity; increased expression of the catalytically active form influences splicing to generate the catalytically inactive splicing variant lacking the kinase domain. Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins. Interacts with PPIG and UBL5. P22518; Q5ZRQ0: lubX; Xeno; NbExp=3; IntAct=EBI-6479117, EBI-6402540; Nucleus Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P22518-1; Sequence=Displayed; Name=Short; Synonyms=Clk1T; IsoId=P22518-2; Sequence=VSP_004854, VSP_004855; Autophosphorylates on all three types of residues. [Isoform Short]: Lacks the kinase domain. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity protein binding ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation regulation of RNA splicing protein autophosphorylation uc007bbs.1 uc007bbs.2 uc007bbs.3 uc007bbs.4 
ENSMUST00000034869.11 Isl2 ENSMUST00000034869.11 insulin related protein 2 (islet 2) (from RefSeq NM_027397.3) ENSMUST00000034869.1 ENSMUST00000034869.10 ENSMUST00000034869.2 ENSMUST00000034869.3 ENSMUST00000034869.4 ENSMUST00000034869.5 ENSMUST00000034869.6 ENSMUST00000034869.7 ENSMUST00000034869.8 ENSMUST00000034869.9 G5E888 ISL2_MOUSE NM_027397 Q9CXV0 uc009psm.1 uc009psm.2 uc009psm.3 Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Interacts with LHX4. Nucleus RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development axonogenesis spinal cord motor neuron cell fate specification visceral motor neuron differentiation retinal ganglion cell axon guidance sequence-specific DNA binding negative regulation of neuron differentiation metal ion binding neuron fate commitment neuron fate specification uc009psm.1 uc009psm.2 uc009psm.3 
ENSMUST00000034874.14 Cyp11a1 ENSMUST00000034874.14 cytochrome P450, family 11, subfamily a, polypeptide 1, transcript variant 1 (from RefSeq NM_019779.4) CP11A_MOUSE Cyp11a Cyp11a1 ENSMUST00000034874.1 ENSMUST00000034874.10 ENSMUST00000034874.11 ENSMUST00000034874.12 ENSMUST00000034874.13 ENSMUST00000034874.2 ENSMUST00000034874.3 ENSMUST00000034874.4 ENSMUST00000034874.5 ENSMUST00000034874.6 ENSMUST00000034874.7 ENSMUST00000034874.8 ENSMUST00000034874.9 NM_019779 Q9QZ82 uc009pwa.1 uc009pwa.2 uc009pwa.3 A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron- sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Reaction=cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] = 4- methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone; Xref=Rhea:RHEA:35739, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:16581, ChEBI:CHEBI:17998, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; EC=1.14.15.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35740; Evidence=; Reaction=cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (22R)- hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:34335, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:67237; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:34336; Evidence=; Reaction=(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:34339, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:1294, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:67237; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:34340; Evidence=; Reaction=(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone; Xref=Rhea:RHEA:34343, Rhea:RHEA-COMP:9998, Rhea:RHEA- COMP:9999, ChEBI:CHEBI:1294, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16581, ChEBI:CHEBI:17998, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:34344; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Lipid metabolism; C21-steroid hormone metabolism. Steroid metabolism; cholesterol metabolism. Interacts with FDX1/adrenodoxin. Mitochondrion inner membrane ; Peripheral membrane protein Note=Localizes to the matrix side of the mitochondrion inner membrane. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding mitochondrion mitochondrial inner membrane lipid metabolic process steroid biosynthetic process C21-steroid hormone biosynthetic process glucocorticoid biosynthetic process mating behavior steroid metabolic process cholesterol metabolic process C21-steroid hormone metabolic process cholesterol monooxygenase (side-chain-cleaving) activity cholesterol binding membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding mitochondrial crista cortisol metabolic process response to hydrogen peroxide perikaryon metal ion binding oxidation-reduction process cellular response to peptide hormone stimulus uc009pwa.1 uc009pwa.2 uc009pwa.3 
ENSMUST00000034876.10 Tspan3 ENSMUST00000034876.10 tetraspanin 3 (from RefSeq NM_019793.3) ENSMUST00000034876.1 ENSMUST00000034876.2 ENSMUST00000034876.3 ENSMUST00000034876.4 ENSMUST00000034876.5 ENSMUST00000034876.6 ENSMUST00000034876.7 ENSMUST00000034876.8 ENSMUST00000034876.9 NM_019793 Q9EQG4 Q9QY33 TSN3_MOUSE Tm4sf8 uc009psx.1 uc009psx.2 uc009psx.3 uc009psx.4 Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair. Interacts with claudin-11/CLDN11 and integrins. Membrane ; Multi-pass membrane protein Belongs to the tetraspanin (TM4SF) family. integral component of plasma membrane membrane integral component of membrane cell migration uc009psx.1 uc009psx.2 uc009psx.3 uc009psx.4 
ENSMUST00000034878.12 Tmem30a ENSMUST00000034878.12 transmembrane protein 30A (from RefSeq NM_133718.4) CC50A_MOUSE Cdc50a D9Wsu20e ENSMUST00000034878.1 ENSMUST00000034878.10 ENSMUST00000034878.11 ENSMUST00000034878.2 ENSMUST00000034878.3 ENSMUST00000034878.4 ENSMUST00000034878.5 ENSMUST00000034878.6 ENSMUST00000034878.7 ENSMUST00000034878.8 ENSMUST00000034878.9 NM_133718 Q3TCJ5 Q3UDH8 Q8R0X6 Q8VEH1 Q8VEK0 Tmem30a uc009quw.1 uc009quw.2 uc009quw.3 uc009quw.4 Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF). Can also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. Component of various P4-ATPase flippase complexes which consists of a catalytic alpha subunit and an accessory beta subunit. Interacts with ATP8A1 to form a flippase complex; this complex forms an intermediate phosphoenzyme. The ATP8A2:TMEM30A flippase complex has been purified, and ATP8B1:TMEM30A and ATP8B2:TMEM30A flippase complexes have been shown to form intermediate phosphoenzymes in vitro (By similarity). Interacts with alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C (PubMed:23269685, PubMed:30018401, PubMed:29799007). Q8VEK0; P70704: Atp8a1; NbExp=2; IntAct=EBI-8381028, EBI-20828407; Q8VEK0; P05067-4: APP; Xeno; NbExp=6; IntAct=EBI-8381028, EBI-302641; Q8VEK0; PRO_0000000091 [P05067]: APP; Xeno; NbExp=3; IntAct=EBI-8381028, EBI-3894543; Membrane ; Multi- pass membrane protein Cell membrane Golgi apparatus Cytoplasmic vesicle, secretory vesicle membrane Apical cell membrane Expressed in photoreceptor cells; detected in retina outer segment (at protein level). Detected in hepatocytes liver sinusoidal endothelial cells and kidney brush border of the proximal tubules (at protein level). Expressed in brain (at protein level). The N-terminal domain seems to play a role in the reaction cycle of thr catalytic subunit such as ATP8A2. N-glycosylated. Contains high mannose-type oligosaccharides. Belongs to the CDC50/LEM3 family. Sequence=AAH26136.1; Type=Erroneous initiation; Evidence=; Sequence=BAE41961.1; Type=Frameshift; Evidence=; protein binding endoplasmic reticulum Golgi apparatus plasma membrane drug transmembrane transport lipid transport positive regulation of neuron projection development aminophospholipid transporter activity phospholipid transport aminophospholipid transport membrane integral component of membrane apical plasma membrane transport vesicle membrane cytoplasmic vesicle protein localization to endosome phospholipid translocation positive regulation of protein exit from endoplasmic reticulum uc009quw.1 uc009quw.2 uc009quw.3 uc009quw.4 
ENSMUST00000034879.5 Hmg20a ENSMUST00000034879.5 high mobility group 20A (from RefSeq NM_025812.3) ENSMUST00000034879.1 ENSMUST00000034879.2 ENSMUST00000034879.3 ENSMUST00000034879.4 HM20A_MOUSE Ibraf NM_025812 Q3LSF9 Q6NV87 Q8BSK1 Q8C3C1 Q8CAA0 Q9CYG2 Q9DC33 uc009ptf.1 uc009ptf.2 uc009ptf.3 Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4. Interacts with DTNB. Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9DC33-1; Sequence=Displayed; Name=2; IsoId=Q9DC33-2; Sequence=VSP_018627; Name=3; IsoId=Q9DC33-3; Sequence=VSP_018625, VSP_018626; Name=4; IsoId=Q9DC33-4; Sequence=VSP_018623, VSP_018624; Expressed in brain. Detected in mature neurons. Detected at 16.5 dpc in the outer cortex of the developing brain. Sequence=ABA26278.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter DNA binding nucleus chromatin organization negative regulation of protein sumoylation identical protein binding negative regulation of neuron differentiation protein heterodimerization activity uc009ptf.1 uc009ptf.2 uc009ptf.3 
ENSMUST00000034881.8 Cox7a2 ENSMUST00000034881.8 cytochrome c oxidase subunit 7A2 (from RefSeq NM_009945.3) CX7A2_MOUSE Cox7a3 Cox7al ENSMUST00000034881.1 ENSMUST00000034881.2 ENSMUST00000034881.3 ENSMUST00000034881.4 ENSMUST00000034881.5 ENSMUST00000034881.6 ENSMUST00000034881.7 NM_009945 O54969 P48771 Q545J7 uc009quv.1 uc009quv.2 uc009quv.3 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Energy metabolism; oxidative phosphorylation. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with PET100. Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the cytochrome c oxidase VIIa family. regulation of oxidative phosphorylation molecular_function cytochrome-c oxidase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain electron carrier activity membrane electron transport chain mitochondrial respiratory chain supercomplex assembly hydrogen ion transmembrane transport uc009quv.1 uc009quv.2 uc009quv.3 
ENSMUST00000034883.7 Stoml1 ENSMUST00000034883.7 stomatin-like 1, transcript variant 1 (from RefSeq NM_026942.3) A0A0B4J1F1 A0A0B4J1F1_MOUSE ENSMUST00000034883.1 ENSMUST00000034883.2 ENSMUST00000034883.3 ENSMUST00000034883.4 ENSMUST00000034883.5 ENSMUST00000034883.6 NM_026942 Stoml1 uc009pws.1 uc009pws.2 uc009pws.3 uc009pws.4 Belongs to the band 7/mec-2 family. membrane integral component of membrane uc009pws.1 uc009pws.2 uc009pws.3 uc009pws.4 
ENSMUST00000034889.10 Hcn4 ENSMUST00000034889.10 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 (from RefSeq NM_001081192.3) B2RY58 B2RY58_MOUSE ENSMUST00000034889.1 ENSMUST00000034889.2 ENSMUST00000034889.3 ENSMUST00000034889.4 ENSMUST00000034889.5 ENSMUST00000034889.6 ENSMUST00000034889.7 ENSMUST00000034889.8 ENSMUST00000034889.9 Hcn4 NM_001081192 uc009pxi.1 uc009pxi.2 uc009pxi.3 Cell membrane ; Multi-pass membrane protein Belongs to the potassium channel HCN family. regulation of heart rate regulation of membrane depolarization ion channel activity intracellular cAMP activated cation channel activity voltage-gated ion channel activity voltage-gated sodium channel activity voltage-gated potassium channel activity potassium channel activity plasma membrane ion transport cation transport potassium ion transport sodium ion transport membrane integral component of membrane cAMP binding intrinsic component of plasma membrane regulation of ion transmembrane transport sodium ion transmembrane transport regulation of membrane potential identical protein binding perinuclear region of cytoplasm transmembrane transport regulation of cardiac muscle contraction cellular response to cAMP cellular response to cGMP potassium ion transmembrane transport SA node cell action potential voltage-gated potassium channel activity involved in SA node cell action potential depolarization membrane depolarization during SA node cell action potential regulation of heart rate by cardiac conduction sodium ion import across plasma membrane HCN channel complex regulation of cardiac muscle cell action potential involved in regulation of contraction potassium ion import across plasma membrane uc009pxi.1 uc009pxi.2 uc009pxi.3 
ENSMUST00000034896.13 Mto1 ENSMUST00000034896.13 mitochondrial tRNA translation optimization 1 (from RefSeq NM_026658.2) ENSMUST00000034896.1 ENSMUST00000034896.10 ENSMUST00000034896.11 ENSMUST00000034896.12 ENSMUST00000034896.2 ENSMUST00000034896.3 ENSMUST00000034896.4 ENSMUST00000034896.5 ENSMUST00000034896.6 ENSMUST00000034896.7 ENSMUST00000034896.8 ENSMUST00000034896.9 G5E889 G5E889_MOUSE Mto1 NM_026658 uc009qum.1 uc009qum.2 uc009qum.3 uc009qum.4 Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Belongs to the MnmG family. tRNA wobble uridine modification tRNA processing flavin adenine dinucleotide binding uc009qum.1 uc009qum.2 uc009qum.3 uc009qum.4 
ENSMUST00000034900.8 Ooep ENSMUST00000034900.8 oocyte expressed protein (from RefSeq NM_026480.3) ENSMUST00000034900.1 ENSMUST00000034900.2 ENSMUST00000034900.3 ENSMUST00000034900.4 ENSMUST00000034900.5 ENSMUST00000034900.6 ENSMUST00000034900.7 NM_026480 OOEP_MOUSE Oep19 Q9CWE6 Sddr uc009quh.1 uc009quh.2 uc009quh.3 uc009quh.4 As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (PubMed:29125140). Positively regulates the homologous recombination-mediated DNA double- strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes (PubMed:29955025). Thereby contributes to oocyte survival and the resumption and completion of meiosis (PubMed:29955025). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:18804437, PubMed:25208553). Required for the formation of F- actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (PubMed:25208553). Component of the subcortical maternal complex (SCMC), at least composed of NLRP5, KHDC3, OOEP, and TLE6 (PubMed:18804437, PubMed:28992324). Within the complex, interacts with NLRP5, KHDC3 and TLE6 (PubMed:18804437, PubMed:31575650). The SCMC may facilitate translocation of its components between the nuclear and cytoplasmic compartments (By similarity). As part of the SCMC interacts with the SCMC-associated protein NLRP4F (PubMed:31575650). Forms a scaffold complex with KHDC3/FILIA, and interacts with BLM and TRIM25 at DNA replication forks (PubMed:29125140). Cytoplasm Nucleus Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages (PubMed:18804437, PubMed:25208553). From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (PubMed:18804437). Expression largely disappears in blastocysts (PubMed:25208553). Expressed in ovaries, where it is restricted to growing oocytes, with greatest levels in fully grown oocytes. Transcripts first detected at 15.5 dpc and peak 1 week after birth (PubMed:18804437). Transcripts accumulate during oogenesis (PubMed:18804437). During meiotic maturation, the vast majority of the transcripts are degraded and virtually none is detected by 2-cell stage embryogenesis (PubMed:18804437). The protein however persists during preimplantation up to the blastocyst stage (PubMed:18804437). At 2-cell stage, excluded from cell-cell contact regions (PubMed:18804437). Continuous exclusion from these regions during preimplantation development leads to the absence of the protein from the inner cells of the morula and the inner cell mass of the blastocyst (PubMed:18804437). Expressed in ovaries at postnatal day 2 (P2), expression peaks at P10, expression is then slightly decreased at P17 and further decreased at P21 (PubMed:31575650). Induced by etoposide. Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA. Embryonic death at 2.5 dpc (PubMed:18804437). Progression from embryonic 1- to 2-cell stage delayed 6-8 hours. Less than 20% of the embryos progress beyond 2-cell stage (PubMed:18804437). Embryos form unequal sized blastomeres due to smaller, dysmorphic, and displaced mitotic spindles resulting in asymmetric division (PubMed:25208553). Decrease in thickness of subcortical F-actin in zygotes, thickening of F-actin bundles in the cytoplasm and loss of F- actin cytoplasmic lattices (PubMed:25208553). Decrease in CFL1/Cofilin- 1 expression in the subcortex and diffused distribution in the cytoplasm of zygotes (PubMed:25208553). Decrease in expression of the SCMC component ZBED3 in oocytes (PubMed:28992324). Oocytes exhibit greater amounts of DNA damage and show an inability to repair DNA double strand breaks (PubMed:29955025). Increase in oocyte apoptosis upon treatment with the DNA cross-linking agent cisplatin (PubMed:29955025). Increased number of oocytes in primordial and primary follicles in 4 week old mice, however this number is decreased in 16 week old mice (PubMed:29955025). 4 hour delay in reaching 50% germinal vesicle breakdown (GVB) with a 20% decrease in the number of oocytes that complete GVB. 2 hour delay in reaching 50% polar body extrusion (PBE) with a decrease of 20% in the number of oocytes that complete PBE (PubMed:29955025). Belongs to the KHDC1 family. in utero embryonic development RNA binding protein binding cytoplasm cell cortex protein phosphorylation embryo implantation fertilization embryonic pattern specification macromolecular complex cellular macromolecular complex assembly establishment or maintenance of apical/basal cell polarity apical part of cell uc009quh.1 uc009quh.2 uc009quh.3 uc009quh.4 
ENSMUST00000034902.12 Gsta2 ENSMUST00000034902.12 glutathione S-transferase, alpha 2 (Yc2) (from RefSeq NM_008182.3) ENSMUST00000034902.1 ENSMUST00000034902.10 ENSMUST00000034902.11 ENSMUST00000034902.2 ENSMUST00000034902.3 ENSMUST00000034902.4 ENSMUST00000034902.5 ENSMUST00000034902.6 ENSMUST00000034902.7 ENSMUST00000034902.8 ENSMUST00000034902.9 GSTA2_MOUSE NM_008182 P10648 Q6P8Q1 uc009quf.1 uc009quf.2 uc009quf.3 Catalyzes the conjugation of glutathione to a large variety of electrophilic compounds. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16438; Evidence=; Kinetic parameters: KM=31 uM for 7,8-Dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene ; Vmax=1295 nmol/min/mg enzyme for 7,8-Dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene ; Homodimer (PubMed:12549910). Heterodimer of GSTA1 and GSTA2 (By similarity). Expressed in the kidney. Belongs to the GST superfamily. Alpha family. glutathione transferase activity cytosol glutathione metabolic process xenobiotic metabolic process response to bacterium transferase activity response to stilbenoid glutathione binding uc009quf.1 uc009quf.2 uc009quf.3 
ENSMUST00000034903.7 Gsta4 ENSMUST00000034903.7 glutathione S-transferase, alpha 4 (from RefSeq NM_010357.3) ENSMUST00000034903.1 ENSMUST00000034903.2 ENSMUST00000034903.3 ENSMUST00000034903.4 ENSMUST00000034903.5 ENSMUST00000034903.6 GSTA4_MOUSE Gsta NM_010357 P24472 Q9CQ81 Q9CTY7 Q9CY87 Q9D038 uc009qty.1 uc009qty.2 uc009qty.3 uc009qty.4 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Homodimer. Cytoplasm. The N-terminus is blocked. On the basis of immunological and kinetics data, GST 5.7 is distinct from alpha, mu and pI classes of GTS. However it has been postulated that this protein may be part of a distinct subgroup within this alpha class. The variations were found from AA sequencing and imply there are multiple forms of this protein. These variations are likely to be sex-linked and tissue specific. Belongs to the GST superfamily. Alpha family. glutathione transferase activity cytoplasm mitochondrion glutathione metabolic process xenobiotic metabolic process drug binding response to herbicide response to zinc ion transferase activity response to nicotine glutathione binding cellular response to lithium ion uc009qty.1 uc009qty.2 uc009qty.3 uc009qty.4 
ENSMUST00000034904.14 Elovl5 ENSMUST00000034904.14 ELOVL fatty acid elongase 5 (from RefSeq NM_134255.3) ELOV5_MOUSE ENSMUST00000034904.1 ENSMUST00000034904.10 ENSMUST00000034904.11 ENSMUST00000034904.12 ENSMUST00000034904.13 ENSMUST00000034904.2 ENSMUST00000034904.3 ENSMUST00000034904.4 ENSMUST00000034904.5 ENSMUST00000034904.6 ENSMUST00000034904.7 ENSMUST00000034904.8 ENSMUST00000034904.9 Elovl5 NM_134255 Q8BHI7 Q8BLG6 Q8BUE3 Q8R5D3 uc009qtn.1 uc009qtn.2 uc009qtn.3 uc009qtn.4 Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (PubMed:24184513). Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long- chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=2.3.1.199; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32728; Evidence=; Reaction=(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35379, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57363, ChEBI:CHEBI:57384, ChEBI:CHEBI:71481; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35380; Evidence=; Reaction=(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36523, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74034, ChEBI:CHEBI:74054; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36524; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)- octadecenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:39675, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:61540, ChEBI:CHEBI:76555; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39676; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3- oxoicosenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36511, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:57387, ChEBI:CHEBI:74011; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36512; Evidence=; Reaction=(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z)- eicosenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:39679, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:75121, ChEBI:CHEBI:76559; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39680; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)- 3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36503, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:57384, ChEBI:CHEBI:74012; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36504; Evidence=; Reaction=(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35391, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:71489, ChEBI:CHEBI:71491; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35392; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36475, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:57384, ChEBI:CHEBI:73852; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36476; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36483, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:73862, ChEBI:CHEBI:73863; Evidence=; Lipid metabolism; polyunsaturated fatty acid biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Cell projection, dendrite Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. Belongs to the ELO family. ELOVL5 subfamily. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process fatty acid elongase activity membrane integral component of membrane transferase activity fatty acid elongation, saturated fatty acid sphingolipid biosynthetic process integral component of endoplasmic reticulum membrane dendrite fatty acid elongation, monounsaturated fatty acid fatty acid elongation, polyunsaturated fatty acid long-chain fatty-acyl-CoA biosynthetic process very long-chain fatty acid biosynthetic process cell projection neuronal cell body positive regulation of fatty acid biosynthetic process dendritic tree 3-oxo-arachidoyl-CoA synthase activity 3-oxo-cerotoyl-CoA synthase activity 3-oxo-lignoceronyl-CoA synthase activity uc009qtn.1 uc009qtn.2 uc009qtn.3 uc009qtn.4 
ENSMUST00000034905.9 Gclc ENSMUST00000034905.9 glutamate-cysteine ligase, catalytic subunit, transcript variant 2 (from RefSeq NR_151778.1) ENSMUST00000034905.1 ENSMUST00000034905.2 ENSMUST00000034905.3 ENSMUST00000034905.4 ENSMUST00000034905.5 ENSMUST00000034905.6 ENSMUST00000034905.7 ENSMUST00000034905.8 Gclc NR_151778 Q3TEF1 Q3TEF1_MOUSE uc009qtm.1 uc009qtm.2 uc009qtm.3 uc009qtm.4 Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L- cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235, ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2; Evidence=; Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. Belongs to the glutamate--cysteine ligase type 3 family. magnesium ion binding catalytic activity glutamate-cysteine ligase activity cysteine metabolic process glutamate metabolic process glutathione biosynthetic process response to oxidative stress aging response to nutrient response to heat response to hormone response to activity glutamate binding ligase activity glutamate-cysteine ligase complex cellular response to insulin stimulus cellular response to hepatocyte growth factor stimulus negative regulation of apoptotic process negative regulation of neuron apoptotic process ADP binding cellular response to fibroblast growth factor stimulus response to human chorionic gonadotropin cell redox homeostasis negative regulation of transcription, DNA-templated response to cadmium ion protein heterodimerization activity coenzyme binding response to nitrosative stress response to interleukin-1 cellular response to mechanical stimulus cellular response to glucose stimulus cellular response to follicle-stimulating hormone stimulus cellular response to thyroxine stimulus regulation of blood vessel diameter negative regulation of hepatic stellate cell activation uc009qtm.1 uc009qtm.2 uc009qtm.3 uc009qtm.4 
ENSMUST00000034911.7 Tinag ENSMUST00000034911.7 tubulointerstitial nephritis antigen, transcript variant 1 (from RefSeq NM_012033.3) ENSMUST00000034911.1 ENSMUST00000034911.2 ENSMUST00000034911.3 ENSMUST00000034911.4 ENSMUST00000034911.5 ENSMUST00000034911.6 NM_012033 Q9WUR0 Q9WUR0_MOUSE Tinag uc009qtd.1 uc009qtd.2 uc009qtd.3 uc009qtd.4 Belongs to the peptidase C1 family. scavenger receptor activity extracellular matrix structural constituent basement membrane extracellular space proteolysis endocytosis immune response cell adhesion cysteine-type peptidase activity polysaccharide binding uc009qtd.1 uc009qtd.2 uc009qtd.3 uc009qtd.4 
ENSMUST00000034912.6 Rasgrf1 ENSMUST00000034912.6 RAS protein-specific guanine nucleotide-releasing factor 1, transcript variant 1 (from RefSeq NM_011245.2) Cdc25 ENSMUST00000034912.1 ENSMUST00000034912.2 ENSMUST00000034912.3 ENSMUST00000034912.4 ENSMUST00000034912.5 Grf1 NM_011245 P27671 RGRF1_MOUSE uc009qzt.1 uc009qzt.2 uc009qzt.3 Promotes the exchange of Ras-bound GDP by GTP. Homooligomer and heterooligomer with RASGRF2. Interacts with USP8, thereby regulating its stability. P27671; P12023: App; NbExp=2; IntAct=EBI-645522, EBI-78814; P27671; P01112: HRAS; Xeno; NbExp=2; IntAct=EBI-645522, EBI-350145; Brain. The DH (DBL-homology) domain mediates interaction with RASGRF2. Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome. Ubiquitinated and degraded following phosphorylation by PLK2. Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity (By similarity). guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding cytoplasm cytosol small GTPase mediated signal transduction protein C-terminus binding cell proliferation basolateral plasma membrane apicolateral plasma membrane Ras GTPase binding protein kinase binding growth cone receptor tyrosine kinase binding neuron projection development response to endoplasmic reticulum stress regulation of Rac protein signal transduction regulation of Rho protein signal transduction glutamate receptor binding intracellular signal transduction neuronal cell body positive regulation of GTPase activity regulation of Ras protein signal transduction positive regulation of Ras protein signal transduction positive regulation of fibroblast proliferation regulation of synaptic plasticity regulation of neuronal synaptic plasticity activation of GTPase activity apical dendrite regulation of N-methyl-D-aspartate selective glutamate receptor activity uc009qzt.1 uc009qzt.2 uc009qzt.3 
ENSMUST00000034913.5 Mcrip1 ENSMUST00000034913.5 MAPK regulated corepressor interacting protein 1, transcript variant 2 (from RefSeq NM_001373934.1) ENSMUST00000034913.1 ENSMUST00000034913.2 ENSMUST00000034913.3 ENSMUST00000034913.4 Fam195b MCRI1_MOUSE NM_001373934 Q3UGS4 Q8QZS4 uc007mtf.1 uc007mtf.2 The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. Interacts (unphosphorylated form, via the PXDLS motif) with CTBP1, competitively inhibiting CTBP-ZEB1 interaction. Interacts with CTBP2. Interacts with MCRIP2. Interacts with DDX6. Nucleus Cytoplasm, Stress granule Widely expressed (at protein level). Phosphorylation by MAPK3/1 (ERK1/2) regulates MCRIP1 binding to CTBP(s). Belongs to the MCRIP family. Sequence=AAH25536.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function nucleus cytoplasm cytoplasmic stress granule regulation of epithelial to mesenchymal transition uc007mtf.1 uc007mtf.2 
ENSMUST00000034915.15 Ctsh ENSMUST00000034915.15 cathepsin H, transcript variant 1 (from RefSeq NM_007801.3) CATH_MOUSE ENSMUST00000034915.1 ENSMUST00000034915.10 ENSMUST00000034915.11 ENSMUST00000034915.12 ENSMUST00000034915.13 ENSMUST00000034915.14 ENSMUST00000034915.2 ENSMUST00000034915.3 ENSMUST00000034915.4 ENSMUST00000034915.5 ENSMUST00000034915.6 ENSMUST00000034915.7 ENSMUST00000034915.8 ENSMUST00000034915.9 NM_007801 P49935 Q3UCD6 uc012gyf.1 uc012gyf.2 uc012gyf.3 This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin H mini, heavy, and light chains. In rat and human, these three chains can associate to form the mature enzyme, which has both aminopeptidase and endopeptidase activities. Homozygous knockout mice for this gene exhibit impaired lung surfactant processing and reduced tumorigenesis in a pancreatic cancer model. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]. Important for the overall degradation of proteins in lysosomes. Reaction=Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.; EC=3.4.22.16; Composed of a mini chain and a large chain. The large chain may be split into heavy and light chain. All chains are held together by disulfide bonds. Lysosome. Widely expressed with highest expression found in non-skeletal tissues. Low levels found in skeletal tissue. Mice exhibit markedly abnormal posterior chamber of eyeball with a configuration suggestive of increased axial lengthening, compared to the rounded appearance in wild-type littermates. Belongs to the peptidase C1 family. outer dense fiber metanephros development acrosomal vesicle T cell mediated cytotoxicity adaptive immune response immune response-regulating signaling pathway endopeptidase activity aminopeptidase activity cysteine-type endopeptidase activity serine-type endopeptidase activity extracellular space lysosome cytosol axoneme proteolysis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process peptidase activity cysteine-type peptidase activity positive regulation of cell proliferation cysteine-type endopeptidase activator activity involved in apoptotic process positive regulation of gene expression positive regulation of epithelial cell migration neuropeptide catabolic process bradykinin catabolic process positive regulation of peptidase activity peptidase activator activity involved in apoptotic process hydrolase activity HLA-A specific activating MHC class I receptor activity positive regulation of cell migration kininogen binding zymogen activation protein destabilization response to retinoic acid membrane protein proteolysis cytoplasmic ribonucleoprotein granule negative regulation of apoptotic process surfactant homeostasis intracellular membrane-bounded organelle protein self-association macromolecular complex binding positive regulation of angiogenesis proteolysis involved in cellular protein catabolic process dichotomous subdivision of terminal units involved in lung branching thyroid hormone binding ERK1 and ERK2 cascade cellular response to thyroid hormone stimulus alveolar lamellar body positive regulation of apoptotic signaling pathway uc012gyf.1 uc012gyf.2 uc012gyf.3 
ENSMUST00000034920.11 Map2k5 ENSMUST00000034920.11 mitogen-activated protein kinase kinase 5, transcript variant 1 (from RefSeq NM_011840.3) ENSMUST00000034920.1 ENSMUST00000034920.10 ENSMUST00000034920.2 ENSMUST00000034920.3 ENSMUST00000034920.4 ENSMUST00000034920.5 ENSMUST00000034920.6 ENSMUST00000034920.7 ENSMUST00000034920.8 ENSMUST00000034920.9 MP2K5_MOUSE Mek5 Mkk5 NM_011840 Prkmk5 Q8CFM3 Q8K360 Q9D222 Q9WVS7 uc009qaw.1 uc009qaw.2 uc009qaw.3 Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI. Q9WVS7; Q61083: Map3k2; NbExp=4; IntAct=EBI-446144, EBI-446134; Q9WVS7; Q61084: Map3k3; NbExp=15; IntAct=EBI-446144, EBI-446250; Q9WVS7; P28656: Nap1l1; NbExp=20; IntAct=EBI-446144, EBI-645055; Q9WVS7; Q64337: Sqstm1; NbExp=3; IntAct=EBI-446144, EBI-645025; Cytoplasm Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9WVS7-1; Sequence=Displayed; Name=2; IsoId=Q9WVS7-2; Sequence=VSP_015840; Name=3; IsoId=Q9WVS7-3; Sequence=VSP_015838, VSP_015839; Name=4; IsoId=Q9WVS7-4; Sequence=VSP_015836, VSP_015837; Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the PB1 domain. This domain also mediates interactions with SQSTM1 and PARD6A. Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. negative regulation of transcription from RNA polymerase II promoter MAPK cascade nucleotide binding activation of MAPK activity protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein tyrosine kinase activity protein binding ATP binding nucleus cytoplasm spindle cytosol protein phosphorylation heart development kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation signal transduction by protein phosphorylation positive regulation of cell growth negative regulation of NF-kappaB transcription factor activity activation of protein kinase activity negative regulation of heterotypic cell-cell adhesion negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of interleukin-8 biosynthetic process positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of epithelial cell proliferation positive regulation of protein metabolic process negative regulation of response to cytokine stimulus ERK5 cascade cellular response to growth factor stimulus negative regulation of cell migration involved in sprouting angiogenesis negative regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc009qaw.1 uc009qaw.2 uc009qaw.3 
ENSMUST00000034927.13 Zic1 ENSMUST00000034927.13 zinc finger protein of the cerebellum 1, transcript variant 1 (from RefSeq NM_009573.4) ENSMUST00000034927.1 ENSMUST00000034927.10 ENSMUST00000034927.11 ENSMUST00000034927.12 ENSMUST00000034927.2 ENSMUST00000034927.3 ENSMUST00000034927.4 ENSMUST00000034927.5 ENSMUST00000034927.6 ENSMUST00000034927.7 ENSMUST00000034927.8 ENSMUST00000034927.9 NM_009573 P46684 Q6PAK5 Q80Y18 ZIC1_MOUSE Zic uc009rag.1 uc009rag.2 uc009rag.3 Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5). Interacts with GLI1; the interaction enhances transcription activation. Interacts with GLI2. Interacts with GLI3; the interaction enhances transcription activation. P46684; Q8K0K3: Gli2; NbExp=2; IntAct=EBI-308006, EBI-308039; P46684; P08151: GLI1; Xeno; NbExp=2; IntAct=EBI-308006, EBI-308084; P46684; P10071: GLI3; Xeno; NbExp=2; IntAct=EBI-308006, EBI-308055; Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. Expressed in osteoblasts (at protein level). Expressed in the CNS. A high level expression is seen in the cerebellum, while a low level expression is seen in the olfactory bulb, diencephalon, and brainstem. Expressed in lumbar spine and iliac crest. Expressed in progenitor cells in the dorsal third of the ventricular zone at 12.5 dpc. Expressed in newly emerging pontine gray nucleus (PGN) precursor cells of the extramural migratory stream (ems) between 12.5 and 14.5 dpc. Expressed in precerebellar mossy fiber (MF) neurons of the PGN (located either rostromedially or caudolaterally) persisted through at least P8 after birth (at protein level). In the early embryonic stage, it is expressed in the dorsal half of the neural tube and adjacent mesenchyme, and in the developing cerebellum it is expressed persistently in the granule cell lineage throughout the prenatal and postnatal periods. The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation. Mice show a cell mass decrease of the spinal dorsal horn, hypoplasia and abnormal foliation patterns in the cerebellum. Belongs to the GLI C2H2-type zinc-finger protein family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm multicellular organism development pattern specification process nervous system development central nervous system development brain development adult walking behavior regulation of smoothened signaling pathway spinal cord development cell differentiation positive regulation of protein import into nucleus inner ear morphogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding uc009rag.1 uc009rag.2 uc009rag.3 
ENSMUST00000034929.7 Lactb ENSMUST00000034929.7 lactamase, beta, transcript variant 1 (from RefSeq NM_030717.2) ENSMUST00000034929.1 ENSMUST00000034929.2 ENSMUST00000034929.3 ENSMUST00000034929.4 ENSMUST00000034929.5 ENSMUST00000034929.6 LACTB_MOUSE Lact1 Lactb NM_030717 Q9EP89 uc009qfn.1 uc009qfn.2 Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (By similarity). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (By similarity). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (By similarity). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758). Mitochondrion Expressed predominantly in liver. Down-regulated in a number of cancer cells. Belongs to the peptidase S12 family. mitochondrion cytosol proteolysis lipid metabolic process peptidase activity hydrolase activity regulation of lipid metabolic process identical protein binding uc009qfn.1 uc009qfn.2 
ENSMUST00000034934.15 Aph1b ENSMUST00000034934.15 aph1 homolog B, gamma secretase subunit (from RefSeq NM_177583.4) APH1B_MOUSE ENSMUST00000034934.1 ENSMUST00000034934.10 ENSMUST00000034934.11 ENSMUST00000034934.12 ENSMUST00000034934.13 ENSMUST00000034934.14 ENSMUST00000034934.2 ENSMUST00000034934.3 ENSMUST00000034934.4 ENSMUST00000034934.5 ENSMUST00000034934.6 ENSMUST00000034934.7 ENSMUST00000034934.8 ENSMUST00000034934.9 NM_177583 Q3U3B5 Q8C7N7 Q8CEC9 uc009qfe.1 uc009qfe.2 uc009qfe.3 Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A (By similarity). Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist (By similarity). Interacts with PSEN1 and PSEN2 (By similarity). Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C7N7-1; Sequence=Displayed; Name=2; IsoId=Q8C7N7-2; Sequence=VSP_008359, VSP_008360; Belongs to the APH-1 family. endopeptidase activity endoplasmic reticulum plasma membrane integral component of plasma membrane Notch signaling pathway Notch receptor processing membrane integral component of membrane protein processing transport vesicle positive regulation of catalytic activity gamma-secretase complex uc009qfe.1 uc009qfe.2 uc009qfe.3 
ENSMUST00000034941.9 Plscr4 ENSMUST00000034941.9 phospholipid scramblase 4, transcript variant 1 (from RefSeq NM_178711.4) ENSMUST00000034941.1 ENSMUST00000034941.2 ENSMUST00000034941.3 ENSMUST00000034941.4 ENSMUST00000034941.5 ENSMUST00000034941.6 ENSMUST00000034941.7 ENSMUST00000034941.8 NM_178711 P58196 PLS4_MOUSE Q3TMI2 Q8BH62 uc009ras.1 uc009ras.2 uc009ras.3 May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with PDCD6. Membrane ; Single-pass type II membrane protein The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity. Belongs to the phospholipid scramblase family. plasma membrane membrane integral component of membrane phospholipid scrambling phospholipid scramblase activity enzyme binding CD4 receptor binding cellular response to lipopolysaccharide uc009ras.1 uc009ras.2 uc009ras.3 
ENSMUST00000034944.9 Dapk2 ENSMUST00000034944.9 death-associated protein kinase 2, transcript variant 2 (from RefSeq NM_010019.4) DAPK2_MOUSE ENSMUST00000034944.1 ENSMUST00000034944.2 ENSMUST00000034944.3 ENSMUST00000034944.4 ENSMUST00000034944.5 ENSMUST00000034944.6 ENSMUST00000034944.7 ENSMUST00000034944.8 NM_010019 O88861 Q8VDF3 Q9QYM4 uc009qen.1 uc009qen.2 uc009qen.3 uc009qen.4 Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity). Regulates granulocytes motility by controlling cell spreading and polarization (PubMed:24163421). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by Ca(2+)/calmodulin. Regulated by a double locking mechanism, involving autophosphorylation at Ser-318, calmodulin binding, and dimerization. In the inactive state, Ser-318 is phosphorylated, and the kinase is dimeric. Activation involves: dephosphorylation at Ser-318, release-of-autoinhibition mechanism where calmodulin binding induces a conformational change that relieves the steric block of the active site by the autoinhibitory domain, and generation of the monomeric active form of the kinase. Homodimer in its autoinhibited state. Active as monomer. Interacts with 14-3-3 proteins YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN; the interaction requires DAPK2 phosphorylation at Thr-369 and suppresses DAPK2 kinase activity and DAPK2-induced apoptosis. Cytoplasm Cytoplasmic vesicle, autophagosome lumen Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha; IsoId=Q8VDF3-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q8VDF3-2; Sequence=VSP_042058; Expressed in peritubular interstitial cells of the renal cortex (PubMed:24906443). Isoform 1 is found in the adult brain while isoform 2 is expressed in brains of embryos and young mice (at protein level) (PubMed:21408167). The autoinhibitory domain sterically blocks the substrate peptide-binding site by making both hydrophobic and electrostatic contacts with the kinase core. Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF-alpha receptors. No visible phenotype. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity calmodulin binding ATP binding nucleus cytoplasm Golgi apparatus protein phosphorylation apoptotic process kinase activity phosphorylation transferase activity cytoplasmic vesicle autophagosome lumen intracellular signal transduction identical protein binding intracellular membrane-bounded organelle anoikis positive regulation of neutrophil chemotaxis neutrophil migration positive regulation of eosinophil chemotaxis regulation of intrinsic apoptotic signaling pathway uc009qen.1 uc009qen.2 uc009qen.3 uc009qen.4 
ENSMUST00000034945.6 Ciao2a ENSMUST00000034945.6 cytosolic iron-sulfur assembly component 2A, transcript variant 1 (from RefSeq NM_026635.3) CIA2A_MOUSE ENSMUST00000034945.1 ENSMUST00000034945.2 ENSMUST00000034945.3 ENSMUST00000034945.4 ENSMUST00000034945.5 Fam96a NM_026635 Q3TD02 Q9D171 Q9DCL2 uc009qel.1 uc009qel.2 uc009qel.3 Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004). As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004). May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1 (PubMed:25716227). Monomer and homodimer (By similarity). Component of the CIA complex (PubMed:23891004). Interacts with CIAO1 (PubMed:23891004). Interacts with IREB2 (PubMed:23891004). Interacts with APAF1 (By similarity). Cytoplasm Expressed in interstitial cell lineages. Belongs to the MIP18 family. protein binding nucleus nucleoplasm cytoplasm cytosol chromosome segregation iron-sulfur cluster assembly metal ion binding CIA complex protein maturation by iron-sulfur cluster transfer uc009qel.1 uc009qel.2 uc009qel.3 
ENSMUST00000034946.15 Snx1 ENSMUST00000034946.15 sorting nexin 1 (from RefSeq NM_019727.2) ENSMUST00000034946.1 ENSMUST00000034946.10 ENSMUST00000034946.11 ENSMUST00000034946.12 ENSMUST00000034946.13 ENSMUST00000034946.14 ENSMUST00000034946.2 ENSMUST00000034946.3 ENSMUST00000034946.4 ENSMUST00000034946.5 ENSMUST00000034946.6 ENSMUST00000034946.7 ENSMUST00000034946.8 ENSMUST00000034946.9 NM_019727 Q6NZD2 Q6NZD2_MOUSE Snx1 uc009qek.1 uc009qek.2 uc009qek.3 Cell projection, lamellipodium Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the sorting nexin family. epidermal growth factor receptor binding insulin receptor binding cytoplasm lysosome endosome early endosome cytosol intracellular protein transport endosome membrane membrane endosomal transport retromer complex retromer, tubulation complex receptor internalization early endosome membrane vesicle macromolecular complex early endosome to Golgi transport phosphatidylinositol binding retrograde transport, endosome to Golgi identical protein binding protein homodimerization activity intracellular membrane-bounded organelle positive regulation of protein catabolic process protein heterodimerization activity lamellipodium morphogenesis transferrin receptor binding leptin receptor binding uc009qek.1 uc009qek.2 uc009qek.3 
ENSMUST00000034947.7 Ppib ENSMUST00000034947.7 peptidylprolyl isomerase B (from RefSeq NM_011149.2) CyP-20b ENSMUST00000034947.1 ENSMUST00000034947.2 ENSMUST00000034947.3 ENSMUST00000034947.4 ENSMUST00000034947.5 ENSMUST00000034947.6 NM_011149 Ppib Q9DCY1 Q9DCY1_MOUSE uc009qei.1 uc009qei.2 uc009qei.3 PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence= Endoplasmic reticulum lumen Melanosome Belongs to the cyclophilin-type PPIase family. PPIase B subfamily. protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity nucleus endoplasmic reticulum smooth endoplasmic reticulum protein folding cyclosporin A binding isomerase activity positive regulation of multicellular organism growth positive regulation by host of viral process positive regulation by host of viral genome replication perinuclear region of cytoplasm protein stabilization bone development chaperone-mediated protein folding RNA polymerase binding uc009qei.1 uc009qei.2 uc009qei.3 
ENSMUST00000034949.10 Csnk1g1 ENSMUST00000034949.10 casein kinase 1, gamma 1 (from RefSeq NM_173185.2) E9QPK6 ENSMUST00000034949.1 ENSMUST00000034949.2 ENSMUST00000034949.3 ENSMUST00000034949.4 ENSMUST00000034949.5 ENSMUST00000034949.6 ENSMUST00000034949.7 ENSMUST00000034949.8 ENSMUST00000034949.9 KC1G1_MOUSE NM_173185 Q8BTH8 uc009qeg.1 uc009qeg.2 uc009qeg.3 Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CLSPN (By similarity). Regulates fast synaptic transmission mediated by glutamate. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Monomer. Cytoplasm Expressed in both the striatum and the neocortex. Autophosphorylated. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm cytosol plasma membrane protein phosphorylation Wnt signaling pathway kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation protein autophosphorylation positive regulation of canonical Wnt signaling pathway uc009qeg.1 uc009qeg.2 uc009qeg.3 
ENSMUST00000034955.8 Spg21 ENSMUST00000034955.8 SPG21, maspardin, transcript variant 1 (from RefSeq NM_138584.3) ENSMUST00000034955.1 ENSMUST00000034955.2 ENSMUST00000034955.3 ENSMUST00000034955.4 ENSMUST00000034955.5 ENSMUST00000034955.6 ENSMUST00000034955.7 NM_138584 Q3U658 Q3UDT7 Q8C1Y7 Q9CQC8 SPG21_MOUSE uc009qdi.1 uc009qdi.2 uc009qdi.3 May play a role as a negative regulatory factor in CD4- dependent T-cell activation. Interacts with CD4. Interacts with ALDH16A1. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQC8-1; Sequence=Displayed; Name=2; IsoId=Q9CQC8-2; Sequence=VSP_017634; Expressed in cell lines FT.1 and in a L cell fibroblast derivative (at protein level). Belongs to the AB hydrolase superfamily. cytoplasm cytosol biological_process trans-Golgi network transport vesicle CD4 receptor binding intracellular membrane-bounded organelle uc009qdi.1 uc009qdi.2 uc009qdi.3 
ENSMUST00000034960.14 Dpp8 ENSMUST00000034960.14 dipeptidylpeptidase 8, transcript variant 1 (from RefSeq NM_028906.3) DPP8_MOUSE Dpp8 ENSMUST00000034960.1 ENSMUST00000034960.10 ENSMUST00000034960.11 ENSMUST00000034960.12 ENSMUST00000034960.13 ENSMUST00000034960.2 ENSMUST00000034960.3 ENSMUST00000034960.4 ENSMUST00000034960.5 ENSMUST00000034960.6 ENSMUST00000034960.7 ENSMUST00000034960.8 ENSMUST00000034960.9 NM_028906 Q80YA7 Q9D4G6 uc009qcq.1 uc009qcq.2 uc009qcq.3 Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (By similarity). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29396289). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (By similarity). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity). Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.; EC=3.4.14.5; Evidence=; Inhibited by zinc (By similarity). Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfluorophosphate (By similarity). Specifically inhibited by isoindoline derivatives (By similarity). Inhibited by Val-boroPro (Talabostat, PT-100), a non-selective inhibitor, which triggers pyroptosis in monocytes and macrophages (PubMed:27820798, PubMed:29396289). Homodimer (By similarity). Forms a ternary complex with NLRP1, composed of a DPP8 homodimer, one full-length NLRP1 protein, and one cleaved C-terminus of NLRP1 (NACHT, LRR and PYD domains-containing protein 1, C-terminus) (By similarity). Forms a ternary complex with CARD8, composed of a DPP8 homodimer, one full-length NLRP1 protein, and one cleaved C-terminus of CARD8 (Caspase recruitment domain-containing protein 8, C-terminus) (By similarity). In the ternary complex, only one subunit of the DPP8 homodimer is bound to NLRP1 or CARD8 (By similarity). Cytoplasm Belongs to the peptidase S9B family. DPPIV subfamily. molecular_function aminopeptidase activity cytoplasm cytosol proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009qcq.1 uc009qcq.2 uc009qcq.3 
ENSMUST00000034965.8 Snapc5 ENSMUST00000034965.8 small nuclear RNA activating complex, polypeptide 5 (from RefSeq NM_183316.3) E9QPK5 ENSMUST00000034965.1 ENSMUST00000034965.2 ENSMUST00000034965.3 ENSMUST00000034965.4 ENSMUST00000034965.5 ENSMUST00000034965.6 ENSMUST00000034965.7 NM_183316 Q8R2K7 SNPC5_MOUSE Snapc5 uc009qbo.1 uc009qbo.2 uc009qbo.3 Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity). Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC5 interacts with SNAPC4 (By similarity). Nucleus transcription factor activity, sequence-specific DNA binding nucleus nucleolus regulation of transcription, DNA-templated transcription from RNA polymerase II promoter transcription initiation from RNA polymerase III promoter nuclear body uc009qbo.1 uc009qbo.2 uc009qbo.3 
ENSMUST00000034966.9 Rpl4 ENSMUST00000034966.9 ribosomal protein L4 (from RefSeq NM_024212.5) ENSMUST00000034966.1 ENSMUST00000034966.2 ENSMUST00000034966.3 ENSMUST00000034966.4 ENSMUST00000034966.5 ENSMUST00000034966.6 ENSMUST00000034966.7 ENSMUST00000034966.8 NM_024212 Q9CY08 Q9D8E6 RL4_MOUSE uc009qbn.1 uc009qbn.2 uc009qbn.3 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit (PubMed:36517592). May bind IPO9 with low affinity (By similarity). Interacts with RBM3 (By similarity). Cytoplasm Citrullinated by PADI4. Belongs to the universal ribosomal protein uL4 family. structural constituent of ribosome protein binding nucleus rough endoplasmic reticulum ribosome translation 5S rRNA binding postsynaptic density large ribosomal subunit cytosolic large ribosomal subunit A band positive regulation of axon extension positive regulation of axonogenesis ribonucleoprotein complex uc009qbn.1 uc009qbn.2 uc009qbn.3 
ENSMUST00000034969.14 Lctl ENSMUST00000034969.14 lactase-like (from RefSeq NM_145835.3) ENSMUST00000034969.1 ENSMUST00000034969.10 ENSMUST00000034969.11 ENSMUST00000034969.12 ENSMUST00000034969.13 ENSMUST00000034969.2 ENSMUST00000034969.3 ENSMUST00000034969.4 ENSMUST00000034969.5 ENSMUST00000034969.6 ENSMUST00000034969.7 ENSMUST00000034969.8 ENSMUST00000034969.9 Klph LCTL_MOUSE NM_145835 Q8BPR1 Q8K1F9 Q8K2M9 uc009qbl.1 uc009qbl.2 Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. May form dimers. Endoplasmic reticulum membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K1F9-1; Sequence=Displayed; Name=3; IsoId=Q8K1F9-3; Sequence=VSP_015833, VSP_015834; Strongly expressed in the lens of the eye, where it localizes to the equatorial epithelium and outer layers of newly extending fiber cells (at protein level) (PubMed:29425878). May also be expressed in kidney and skin (PubMed:12084582). However, another study suggests that expression is specific to eye and is minimal in other tissues (PubMed:29425878). No visible phenotype. The lens of the eye appears normal in young animals. However, formation of the lens suture is abnormal with an X-shaped or double-Y shaped morphology instead of a tight Y-shaped pattern. Optics of the lens are distorted and cortical cataracts develop; the phenotype progressively worsens with age. Expression of CLIC5 in the lens epithelium is almost completely absent. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. Although it belongs to the glycosyl hydrolase 1 family, Asp- 200 is present instead of the conserved Glu which is an active site residue. It is therefore expected that this protein lacks glycosidase activity. Sequence=AAH30631.1; Type=Erroneous initiation; Evidence=; lens morphogenesis in camera-type eye hydrolase activity, hydrolyzing O-glycosyl compounds endoplasmic reticulum endoplasmic reticulum membrane brush border carbohydrate metabolic process visual perception beta-glucosidase activity membrane integral component of membrane response to stimulus uc009qbl.1 uc009qbl.2 
ENSMUST00000034973.10 Smad3 ENSMUST00000034973.10 SMAD family member 3 (from RefSeq NM_016769.4) ENSMUST00000034973.1 ENSMUST00000034973.2 ENSMUST00000034973.3 ENSMUST00000034973.4 ENSMUST00000034973.5 ENSMUST00000034973.6 ENSMUST00000034973.7 ENSMUST00000034973.8 ENSMUST00000034973.9 Madh3 NM_016769 O09064 O09144 O14510 O35273 Q8BUN5 Q8BX84 Q92940 Q93002 Q9GKR4 SMAD3_MOUSE uc009qbi.1 uc009qbi.2 Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). Monomer; in the absence of TGF-beta (By similarity). Homooligomer; in the presence of TGF-beta (By similarity). Heterotrimer; forms a heterotrimer in the presence of TGF-beta consisting of two molecules of C-terminally phosphorylated SMAD2 or SMAD3 and one of SMAD4 to form the transcriptionally active SMAD2/SMAD3-SMAD4 complex (PubMed:21145499). Part of a complex consisting of MAGI2/ARIP1, ACVR2A, ACVR1B and SMAD3 (PubMed:15496141). Forms a complex with SMAD2 and TRIM33 upon addition of TGF-beta (By similarity). Found in a complex composed of SMAD3, RAN and XPO4; within the complex interacts directly with XPO4 (By similarity). Component of the multimeric complex SMAD3/SMAD4/JUN/FOS which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta (By similarity). Part of a ternary complex composed of SMAD3, ITCH/AIP4 and NEDD9/HEF1; within the complex NEDD9/HEF1 interacts (via N-terminus) with ITCH/AIP4; the complex mediates ubiquitination and proteasomal degradation of NEDD9/HEF1 (By similarity). Interacts with NEDD9; the interaction promotes NEDD9 ubiquitination and proteasomal degradation (By similarity). Interacts (via an N-terminal domain) with JUN (via its basic DNA binding and leucine zipper domains); this interaction is essential for DNA binding and cooperative transcriptional activity in response to TGF-beta (By similarity). Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4 (By similarity). Interacts with PPM1A; the interaction dephosphorylates SMAD3 in the C-terminal SXS motif leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of TGF-beta signaling (By similarity). Interacts (via MH2 domain) with ZMIZ1 (via SP-RING-type domain); in the TGF-beta signaling pathway increases the activity of the SMAD3/SMAD4 transcriptional complex (By similarity). Interacts (when phosphorylated) with RNF111; RNF111 acts as an enhancer of the transcriptional responses by mediating ubiquitination and degradation of SMAD3 inhibitors (PubMed:17341133). Interacts (dephosphorylated form via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination of the TGF-beta signaling (By similarity). Interacts (via MH2 domain) with LEMD3; the interaction represses SMAD3 transcriptional activity through preventing the formation of the heteromeric complex with SMAD4 and translocation to the nucleus (By similarity). Interacts (via the linker region) with EP300 (C-terminal); the interaction promotes SMAD3 acetylation and is enhanced by TGF-beta phosphorylation in the C-terminal of SMAD3 (By similarity). This interaction can be blocked by competitive binding of adenovirus oncoprotein E1A to the same C-terminal site on EP300, which then results in partially inhibited SMAD3/SMAD4 transcriptional activity (By similarity). Interacts with TGFBR1 (By similarity). Interacts with TGFB1I1 (PubMed:14755691). Interacts with PRDM16 (PubMed:17467076). Interacts with SNW1 (By similarity). Interacts (via MH2 domain) with ZFYVE9 (PubMed:15356634). Interacts with HDAC1 (By similarity). Interacts with TGIF2 (By similarity). Interacts with SKOR1 (By similarity). Interacts with SKOR2 (By similarity). Interacts with DACH1; the interaction inhibits the TGF-beta signaling (By similarity). Interacts with RBPMS (By similarity). Interacts (via MH2 domain) with MECOM (By similarity). Interacts with WWTR1 (via its coiled-coil domain) (By similarity). Interacts with SKI; the interaction represses SMAD3 transcriptional activity (By similarity). Interacts with MEN1 (By similarity). Interacts with IL1F7 (By similarity). Interaction with CSNK1G2 (By similarity). Interacts with PDPK1 (via PH domain) (By similarity). Interacts with DAB2; the interactions are enhanced upon TGF-beta stimulation (By similarity). Interacts with USP15 (By similarity). Interacts with PPP5C; the interaction decreases SMAD3 phosphorylation and protein levels (PubMed:22781750). Interacts with LDLRAD4 (via the SMAD interaction motif) (By similarity). Interacts with PMEPA1 (By similarity). Interacts with ZNF451 (By similarity). Interacts with ZFHX3 (By similarity). Interacts weakly with ZNF8 (PubMed:12370310). Interacts with STUB1, HSPA1A, HSPA1B, HSP90AA1 and HSP90AB1 (By similarity). Interacts with YAP1 (when phosphorylated at 'Ser-112') (PubMed:21145499). Interacts with MAGI2/ARIP1 (PubMed:10681527). Interacts (via MH2 domain) with CITED2 (via C-terminus) (By similarity). Interacts with HGS (PubMed:11094085). Interacts with WWP1 (PubMed:15221015). Interacts with TTRAP (PubMed:18039968). Interacts with FOXL2 (PubMed:19106105). Interacts with PML (PubMed:15356634). Interacts with NEDD4L; the interaction requires TGF-beta stimulation (PubMed:15496141). Interacts with ZC3H3 (PubMed:16115198). Interacts with TGIF. Interacts with CREBBP. Interacts with ATF2. Interacts with NEDD9; the interaction is inhibited by oxidation of NEDD9 (By similarity). Q8BUN5; O35625: Axin1; NbExp=2; IntAct=EBI-2337983, EBI-2365912; Q8BUN5; P20263: Pou5f1; NbExp=13; IntAct=EBI-2337983, EBI-1606219; Q8BUN5; P97471: Smad4; NbExp=6; IntAct=EBI-2337983, EBI-5259270; Cytoplasm cleus te=Cytoplasmic and nuclear in the absence of TGF-beta (PubMed:21145499). On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:21145499). Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (By similarity). Co-localizes with LEMD3 at the nucleus inner membrane (By similarity). MAPK-mediated phosphorylation appears to have no effect on nuclear import. PDPK1 prevents its nuclear translocation in response to TGF-beta (By similarity). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (PubMed:21145499). Highly expressed in the brain and ovary. Detected in the pyramidal cells of the hippocampus, granule cells of the dentate gyrus, granular cells of the cerebral cortex and the granulosa cells of the ovary. The MH1 domain is required for DNA binding (By similarity). Also binds zinc ions which are necessary for the DNA binding. The MH2 domain is required for both homomeric and heteromeric interactions and for transcriptional regulation. Sufficient for nuclear import (By similarity). The linker region is required for the TGFbeta-mediated transcriptional activity and acts synergistically with the MH2 domain. Phosphorylated on serine and threonine residues. Enhanced phosphorylation in the linker region on Thr-179, Ser-204 and Ser-208 on EGF and TGF-beta treatment. Ser-208 is the main site of MAPK-mediated phosphorylation. CDK-mediated phosphorylation occurs in a cell-cycle dependent manner and inhibits both the transcriptional activity and antiproliferative functions of SMAD3. This phosphorylation is inhibited by flavopiridol. Maximum phosphorylation at the G(1)/S junction. Also phosphorylated on serine residues in the C-terminal SXS motif by TGFBR1 and ACVR1. TGFBR1-mediated phosphorylation at these C-terminal sites is required for interaction with SMAD4, nuclear location and transactivational activity, and appears to be a prerequisite for the TGF-beta mediated phosphorylation in the linker region. Dephosphorylated in the C-terminal SXS motif by PPM1A. This dephosphorylation disrupts the interaction with SMAD4, promotes nuclear export and terminates TGF-beta-mediated signaling. Phosphorylation at Ser-418 by CSNK1G2/CK1 promotes ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF- beta responses (By similarity). Phosphorylated by PDPK1 (By similarity). Acetylation in the nucleus by EP300 in the MH2 domain regulates positively its transcriptional activity and is enhanced by TGF-beta. Ubiquitinated. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (By similarity). Ubiquitinated by RNF111, leading to its degradation: only SMAD3 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD3 and regulating its turnover (PubMed:17341133). Undergoes STUB1-mediated ubiquitination and degradation (By similarity). Poly-ADP-ribosylated by PARP1 and PARP2. ADP-ribosylation negatively regulates SMAD3 transcriptional responses during the course of TGF-beta signaling. SMAD3 null mice exhibit inhibition of proliferation of mammary gland epithelial cells. Fibrobasts are only partially growth inhibited. Defects in osteoblast differentiation are observed. Animals are osteopenic with less cortical and cancellous bone. Facture healing is accelerated. Decreased bone mineral density (BMD) reflects the inability of osteoblasts to balance osteoclast activity. Wound healing is accelerated to about two and a half times that of normal animals. Wound areas are significantly reduced with less quantities of granulation tissue. There is reduced local infiltration of moncytes and keratinocytes show altered patterns of growth and migration. Accelerated wound healing is observed on castration of null male mice, while null female mice exhibited delayed healing following ovariectomy. Belongs to the dwarfin/SMAD family. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development osteoblast differentiation ureteric bud development response to hypoxia in utero embryonic development mesoderm formation somitogenesis liver development heart looping osteoblast development immune system development DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription cofactor activity transforming growth factor beta receptor binding protein binding collagen binding nucleus nuclear inner membrane nucleoplasm transcription factor complex cytoplasm cytosol plasma membrane regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter activation of cysteine-type endopeptidase activity involved in apoptotic process immune response cell cycle arrest transforming growth factor beta receptor signaling pathway SMAD protein complex assembly gastrulation endoderm development beta-catenin binding transcription factor binding zinc ion binding negative regulation of cell proliferation embryonic pattern specification positive regulation of gene expression positive regulation of alkaline phosphatase activity positive regulation of epithelial to mesenchymal transition regulation of striated muscle tissue development regulation of transforming growth factor beta receptor signaling pathway DEAD/H-box RNA helicase binding evasion or tolerance of host defenses by virus enzyme binding protein kinase binding phosphatase binding signal transduction involved in regulation of gene expression negative regulation of cell growth adrenal gland development positive regulation of cell migration positive regulation of bone mineralization transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity thyroid gland development chromatin DNA binding ubiquitin protein ligase binding mineralocorticoid receptor binding positive regulation of chondrocyte differentiation positive regulation of interleukin-1 beta production regulation of transforming growth factor beta2 production positive regulation of transforming growth factor beta3 production activin receptor signaling pathway macromolecular complex negative regulation of osteoblast proliferation glucocorticoid receptor binding nodal signaling pathway T cell activation negative regulation of protein catabolic process identical protein binding protein homodimerization activity negative regulation of apoptotic process ubiquitin binding receptor complex bHLH transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding cell-cell junction organization positive regulation of nitric oxide biosynthetic process negative regulation of fat cell differentiation negative regulation of osteoblast differentiation positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter SMAD binding metal ion binding paraxial mesoderm morphogenesis developmental growth embryonic foregut morphogenesis embryonic cranial skeleton morphogenesis regulation of epithelial cell proliferation negative regulation of inflammatory response regulation of immune response protein stabilization positive regulation of positive chemotaxis regulation of binding negative regulation of cytosolic calcium ion concentration positive regulation of stress fiber assembly positive regulation of focal adhesion assembly pericardium development transdifferentiation SMAD protein signal transduction negative regulation of wound healing negative regulation of lung blood pressure lens fiber cell differentiation co-SMAD binding R-SMAD binding primary miRNA binding SMAD protein complex SMAD2-SMAD3 protein complex cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of extracellular matrix assembly positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of cardiac muscle hypertrophy in response to stress uc009qbi.1 uc009qbi.2 
ENSMUST00000034982.16 Tfdp2 ENSMUST00000034982.16 transcription factor Dp 2, transcript variant 72 (from RefSeq NM_001408582.1) ENSMUST00000034982.1 ENSMUST00000034982.10 ENSMUST00000034982.11 ENSMUST00000034982.12 ENSMUST00000034982.13 ENSMUST00000034982.14 ENSMUST00000034982.15 ENSMUST00000034982.2 ENSMUST00000034982.3 ENSMUST00000034982.4 ENSMUST00000034982.5 ENSMUST00000034982.6 ENSMUST00000034982.7 ENSMUST00000034982.8 ENSMUST00000034982.9 F7AYT3 NM_001408582 Q8BHD2 Q8BHD2_MOUSE Tfdp2 uc009rce.1 uc009rce.2 uc009rce.3 uc009rce.4 Nucleus Belongs to the E2F/DP family. mitotic cell cycle DNA binding transcription factor activity, sequence-specific DNA binding transcription cofactor activity nucleus transcription factor complex regulation of transcription, DNA-templated transcription factor binding regulation of cell cycle uc009rce.1 uc009rce.2 uc009rce.3 uc009rce.4 
ENSMUST00000034983.7 Atp1b3 ENSMUST00000034983.7 ATPase, Na+/K+ transporting, beta 3 polypeptide, transcript variant 1 (from RefSeq NM_007502.6) Atp1b3 ENSMUST00000034983.1 ENSMUST00000034983.2 ENSMUST00000034983.3 ENSMUST00000034983.4 ENSMUST00000034983.5 ENSMUST00000034983.6 NM_007502 Q544Q7 Q544Q7_MOUSE uc009rck.1 uc009rck.2 uc009rck.3 uc009rck.4 uc009rck.5 This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic alpha subunit ATP12A. Apical cell membrane ; Single-pass type II membrane protein Basolateral cell membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the X(+)/potassium ATPases subunit beta family. ATPase activator activity sodium:potassium-exchanging ATPase activity plasma membrane sodium:potassium-exchanging ATPase complex caveola ion transport potassium ion transport sodium ion transport cellular sodium ion homeostasis establishment or maintenance of transmembrane electrochemical gradient membrane integral component of membrane metal ion transport cellular potassium ion homeostasis positive regulation of ATPase activity sodium ion export from cell protein stabilization ATPase binding protein localization to plasma membrane membrane repolarization positive regulation of potassium ion transmembrane transporter activity positive regulation of sodium ion export from cell positive regulation of potassium ion import potassium ion import across plasma membrane uc009rck.1 uc009rck.2 uc009rck.3 uc009rck.4 uc009rck.5 
ENSMUST00000034984.8 Rasa2 ENSMUST00000034984.8 RAS p21 protein activator 2 (from RefSeq NM_053268.2) ENSMUST00000034984.1 ENSMUST00000034984.2 ENSMUST00000034984.3 ENSMUST00000034984.4 ENSMUST00000034984.5 ENSMUST00000034984.6 ENSMUST00000034984.7 G3X918 NM_053268 P58069 RASA2_MOUSE uc009rcn.1 uc009rcn.2 uc009rcn.3 Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) and phospholipids. Cell membrane GTPase activator activity phospholipid binding plasma membrane signal transduction membrane intracellular signal transduction regulation of GTPase activity positive regulation of GTPase activity negative regulation of Ras protein signal transduction metal ion binding uc009rcn.1 uc009rcn.2 uc009rcn.3 
ENSMUST00000034986.14 Ube3d ENSMUST00000034986.14 ubiquitin protein ligase E3D, transcript variant 1 (from RefSeq NM_027394.3) ENSMUST00000034986.1 ENSMUST00000034986.10 ENSMUST00000034986.11 ENSMUST00000034986.12 ENSMUST00000034986.13 ENSMUST00000034986.2 ENSMUST00000034986.3 ENSMUST00000034986.4 ENSMUST00000034986.5 ENSMUST00000034986.6 ENSMUST00000034986.7 ENSMUST00000034986.8 ENSMUST00000034986.9 H10bh NM_027394 Q8BX13 UBE3D_MOUSE Ube2cbp uc009qxc.1 uc009qxc.2 uc009qxc.3 E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Protein modification; protein ubiquitination. Interacts with UBE2C/UbcH10 (E2 ubiquitin-conjugating enzyme). Cytoplasm The C-terminal half (AA 167-368) is able to bind cyclin-B and shows a self-ubiquitination activity (mono-, poly, or multi- ubiquitination) in a HECT-like sequence dependent manner. Ubiquitinated by UBCH10 (E2 ubiquitin-conjugating enzyme). ubiquitin ligase complex protein polyubiquitination nucleus cytoplasm cytosol protein monoubiquitination protein ubiquitination transferase activity cyclin binding ubiquitin conjugating enzyme binding proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-like protein conjugating enzyme binding protein autoubiquitination ubiquitin protein ligase activity uc009qxc.1 uc009qxc.2 uc009qxc.3 
ENSMUST00000034988.10 Rwdd2a ENSMUST00000034988.10 RWD domain containing 2A, transcript variant 1 (from RefSeq NM_027100.2) ENSMUST00000034988.1 ENSMUST00000034988.2 ENSMUST00000034988.3 ENSMUST00000034988.4 ENSMUST00000034988.5 ENSMUST00000034988.6 ENSMUST00000034988.7 ENSMUST00000034988.8 ENSMUST00000034988.9 NM_027100 Q14BN8 Q14BN8_MOUSE Rwdd2 Rwdd2a uc009qxp.1 uc009qxp.2 uc009qxp.3 uc009qxp.4 uc009qxp.1 uc009qxp.2 uc009qxp.3 uc009qxp.4 
ENSMUST00000034989.15 Me1 ENSMUST00000034989.15 malic enzyme 1, NADP(+)-dependent, cytosolic, transcript variant 1 (from RefSeq NM_008615.2) ENSMUST00000034989.1 ENSMUST00000034989.10 ENSMUST00000034989.11 ENSMUST00000034989.12 ENSMUST00000034989.13 ENSMUST00000034989.14 ENSMUST00000034989.2 ENSMUST00000034989.3 ENSMUST00000034989.4 ENSMUST00000034989.5 ENSMUST00000034989.6 ENSMUST00000034989.7 ENSMUST00000034989.8 ENSMUST00000034989.9 MAOX_MOUSE Mod-1 Mod1 NM_008615 P06801 Q9DBF9 uc012gxt.1 uc012gxt.2 uc012gxt.3 Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate. Reaction=(S)-malate + NADP(+) = CO2 + NADPH + pyruvate; Xref=Rhea:RHEA:18253, ChEBI:CHEBI:15361, ChEBI:CHEBI:15589, ChEBI:CHEBI:16526, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.40; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18254; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18255; Evidence=; Reaction=H(+) + oxaloacetate = CO2 + pyruvate; Xref=Rhea:RHEA:15641, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526; EC=1.1.1.40; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15642; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Divalent metal cations. Prefers magnesium or manganese. ; Homotetramer. Cytoplasm Belongs to the malic enzymes family. malic enzyme activity malate dehydrogenase (decarboxylating) (NAD+) activity malate dehydrogenase (decarboxylating) (NADP+) activity protein binding cytoplasm mitochondrion cytosol pyruvate metabolic process malate metabolic process oxaloacetate decarboxylase activity response to hormone oxidoreductase activity manganese ion binding metal ion binding NADP binding NAD binding oxidation-reduction process regulation of NADP metabolic process uc012gxt.1 uc012gxt.2 uc012gxt.3 
ENSMUST00000034991.8 Tbx18 ENSMUST00000034991.8 T-box18 (from RefSeq NM_023814.4) ENSMUST00000034991.1 ENSMUST00000034991.2 ENSMUST00000034991.3 ENSMUST00000034991.4 ENSMUST00000034991.5 ENSMUST00000034991.6 ENSMUST00000034991.7 G3X919 G3X919_MOUSE NM_023814 Tbx18 uc009qyh.1 uc009qyh.2 uc009qyh.3 Nucleus Lacks conserved residue(s) required for the propagation of feature annotation. DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated renal system development uc009qyh.1 uc009qyh.2 uc009qyh.3 
ENSMUST00000034992.8 Nt5e ENSMUST00000034992.8 5' nucleotidase, ecto (from RefSeq NM_011851.4) 5NTD_MOUSE ENSMUST00000034992.1 ENSMUST00000034992.2 ENSMUST00000034992.3 ENSMUST00000034992.4 ENSMUST00000034992.5 ENSMUST00000034992.6 ENSMUST00000034992.7 NM_011851 Nt5 Nte Q3U3S1 Q61503 uc009qyj.1 uc009qyj.2 uc009qyj.3 uc009qyj.4 This gene encodes a membrane-bound nucleotidase that hydrolyzes extracellular nucleoside monophosphates. The encoded preproprotein undergoes proteolytic processing to generate to a functional, homodimeric enzyme that preferentially uses adenosine monophosphate as a substrate to generate free adenosine. Mice lacking the encoded protein exhibit a significantly reduced fall in stop flow pressure and superficial nephron glomerular filtration rate in response to a saturating increase of tubular perfusion flow. [provided by RefSeq, Sep 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK029979.1, AK154614.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (PubMed:8224905). Hydrolyzes IMP (PubMed:8224905). Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms (By similarity). Although AMP is the preferred substrate can also hydrolyze UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN (By similarity). Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377, ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5; Evidence=; Reaction=a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'- deoxyribonucleoside + phosphate; Xref=Rhea:RHEA:36167, ChEBI:CHEBI:15377, ChEBI:CHEBI:18274, ChEBI:CHEBI:43474, ChEBI:CHEBI:65317; EC=3.1.3.89; Evidence=; Reaction=dTMP + H2O = phosphate + thymidine; Xref=Rhea:RHEA:11080, ChEBI:CHEBI:15377, ChEBI:CHEBI:17748, ChEBI:CHEBI:43474, ChEBI:CHEBI:63528; EC=3.1.3.35; Evidence=; Reaction=CMP + H2O = cytidine + phosphate; Xref=Rhea:RHEA:29367, ChEBI:CHEBI:15377, ChEBI:CHEBI:17562, ChEBI:CHEBI:43474, ChEBI:CHEBI:60377; EC=3.1.3.91; Evidence=; Reaction=H2O + IMP = inosine + phosphate; Xref=Rhea:RHEA:27718, ChEBI:CHEBI:15377, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474, ChEBI:CHEBI:58053; EC=3.1.3.99; Evidence=; Reaction=AMP + H2O = adenosine + phosphate; Xref=Rhea:RHEA:29375, ChEBI:CHEBI:15377, ChEBI:CHEBI:16335, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; Evidence=; Reaction=GMP + H2O = guanosine + phosphate; Xref=Rhea:RHEA:27714, ChEBI:CHEBI:15377, ChEBI:CHEBI:16750, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115; Evidence=; Reaction=H2O + UMP = phosphate + uridine; Xref=Rhea:RHEA:29359, ChEBI:CHEBI:15377, ChEBI:CHEBI:16704, ChEBI:CHEBI:43474, ChEBI:CHEBI:57865; Evidence=; Reaction=dAMP + H2O = 2'-deoxyadenosine + phosphate; Xref=Rhea:RHEA:29371, ChEBI:CHEBI:15377, ChEBI:CHEBI:17256, ChEBI:CHEBI:43474, ChEBI:CHEBI:58245; Evidence=; Reaction=dCMP + H2O = 2'-deoxycytidine + phosphate; Xref=Rhea:RHEA:29363, ChEBI:CHEBI:15377, ChEBI:CHEBI:15698, ChEBI:CHEBI:43474, ChEBI:CHEBI:57566; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Homodimer. Cell membrane ; Lipid-anchor, GPI-anchor Expressed at high levels in the placenta, kidney, lung and stomach and at lower levels in the thymus, spleen, skeletal muscle and esophagus. Belongs to the 5'-nucleotidase family. nucleotide binding nucleoplasm cytosol plasma membrane AMP catabolic process leukocyte cell-cell adhesion ferrous iron binding 5'-nucleotidase activity nucleotide catabolic process cell surface membrane dephosphorylation hydrolase activity hydrolase activity, acting on ester bonds anchored component of membrane adenosine metabolic process adenosine biosynthetic process metal ion binding negative regulation of inflammatory response synaptic membrane uc009qyj.1 uc009qyj.2 uc009qyj.3 uc009qyj.4 
ENSMUST00000035007.10 Cmtm6 ENSMUST00000035007.10 CKLF-like MARVEL transmembrane domain containing 6, transcript variant 1 (from RefSeq NM_026036.4) CKLF6_MOUSE Cklfsf6 Cmtm6 ENSMUST00000035007.1 ENSMUST00000035007.2 ENSMUST00000035007.3 ENSMUST00000035007.4 ENSMUST00000035007.5 ENSMUST00000035007.6 ENSMUST00000035007.7 ENSMUST00000035007.8 ENSMUST00000035007.9 NM_026036 Q3U7C3 Q922J1 Q9CZ69 uc009ryb.1 uc009ryb.2 uc009ryb.3 Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. Interacts with PD-L1/CD274 (via transmembrane domain); the interaction is direct. Interacts with CMTM4. Interacts with CD58, ARG1, ENO1 and TMPO. Cell membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Recycling endosome membrane Note=Co-localizes with PD-L1/CD274 in the plasma membrane and in recycling endosomes. Belongs to the chemokine-like factor family. molecular_function endosome plasma membrane protein transport membrane integral component of membrane regulation of protein stability early endosome membrane endocytic recycling recycling endosome membrane uc009ryb.1 uc009ryb.2 uc009ryb.3 
ENSMUST00000035009.16 Cmtm7 ENSMUST00000035009.16 CKLF-like MARVEL transmembrane domain containing 7, transcript variant 1 (from RefSeq NM_133978.2) CKLF7_MOUSE Cklfsf7 ENSMUST00000035009.1 ENSMUST00000035009.10 ENSMUST00000035009.11 ENSMUST00000035009.12 ENSMUST00000035009.13 ENSMUST00000035009.14 ENSMUST00000035009.15 ENSMUST00000035009.2 ENSMUST00000035009.3 ENSMUST00000035009.4 ENSMUST00000035009.5 ENSMUST00000035009.6 ENSMUST00000035009.7 ENSMUST00000035009.8 ENSMUST00000035009.9 Lnv NM_133978 Q8CHW2 Q9ESD6 uc009ryc.1 uc009ryc.2 uc009ryc.3 uc009ryc.4 Membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ESD6-1; Sequence=Displayed; Name=2; IsoId=Q9ESD6-2; Sequence=VSP_008267; Belongs to the chemokine-like factor family. B-1a B cell differentiation molecular_function cytokine activity extracellular space chemotaxis signal transduction membrane integral component of membrane uc009ryc.1 uc009ryc.2 uc009ryc.3 uc009ryc.4 
ENSMUST00000035010.10 Stt3b ENSMUST00000035010.10 STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) (from RefSeq NM_024222.3) A0A0R4J0D3 A0A0R4J0D3_MOUSE ENSMUST00000035010.1 ENSMUST00000035010.2 ENSMUST00000035010.3 ENSMUST00000035010.4 ENSMUST00000035010.5 ENSMUST00000035010.6 ENSMUST00000035010.7 ENSMUST00000035010.8 ENSMUST00000035010.9 NM_024222 Stt3b uc009ryp.1 uc009ryp.2 uc009ryp.3 Reaction=a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N- acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L- asparaginy-[protein]; Xref=Rhea:RHEA:22980, Rhea:RHEA-COMP:9529, Rhea:RHEA-COMP:12635, Rhea:RHEA-COMP:12804, Rhea:RHEA-COMP:12805, ChEBI:CHEBI:15378, ChEBI:CHEBI:50347, ChEBI:CHEBI:57497, ChEBI:CHEBI:57570, ChEBI:CHEBI:132529; EC=2.4.99.18; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Membrane ; Multi- pass membrane protein Belongs to the STT3 family. oligosaccharyl transferase activity dolichyl-diphosphooligosaccharide-protein glycotransferase activity endoplasmic reticulum protein glycosylation glycoprotein catabolic process response to unfolded protein membrane integral component of membrane protein N-linked glycosylation via asparagine ER-associated ubiquitin-dependent protein catabolic process macromolecular complex co-translational protein modification post-translational protein modification uc009ryp.1 uc009ryp.2 uc009ryp.3 
ENSMUST00000035014.8 Tgfbr2 ENSMUST00000035014.8 transforming growth factor, beta receptor II, transcript variant 2 (from RefSeq NM_029575.3) ENSMUST00000035014.1 ENSMUST00000035014.2 ENSMUST00000035014.3 ENSMUST00000035014.4 ENSMUST00000035014.5 ENSMUST00000035014.6 ENSMUST00000035014.7 NM_029575 Q62312 Q63947 TGFR2_MOUSE uc009ryt.1 uc009ryt.2 uc009ryt.3 uc009ryt.4 Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity). [Isoform RII-1]: Has transforming growth factor beta- activated receptor activity. [Isoform RII-2]: Has transforming growth factor beta- activated receptor activity. Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA- COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Homodimer. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGFRB1 and TGFRB2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Component of a complex composed of TSC22D1 (via N-terminus), TGFBR1 and TGFBR2; the interaction between TSC22D1 and TGFBR1 is inhibited by SMAD7 and promoted by TGFB1 (By similarity). Interacts with DAXX. Interacts with DYNLT4. Interacts with ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor (By similarity). Interacts with and is activated by SCUBE3; this interaction does not affect TGFB1-binding to TGFBR2 (By similarity). Interacts with VPS39; this interaction is independent of the receptor kinase activity and of the presence of TGF-beta (By similarity). Interacts with CLU (By similarity). Q62312; P55284: Cdh5; NbExp=4; IntAct=EBI-2899332, EBI-7087433; Q62312; P98083-1: Shc1; NbExp=2; IntAct=EBI-2899332, EBI-7533258; Q62312; P98083-2: Shc1; NbExp=3; IntAct=EBI-2899332, EBI-1019301; Q62312; Q64729: Tgfbr1; NbExp=3; IntAct=EBI-2899332, EBI-2899393; Q62312; Q8TDM6: DLG5; Xeno; NbExp=3; IntAct=EBI-2899332, EBI-715138; Cell membrane ; Single-pass type I membrane protein Membrane raft Event=Alternative splicing; Named isoforms=2; Name=RII-1; IsoId=Q62312-2; Sequence=Displayed; Name=RII-2; IsoId=Q62312-1; Sequence=VSP_061515; Widely expressed in adult. Expressed primarily in mesenchyme and epidermis of the midgestational fetus. Phosphorylated on a Ser/Thr residue in the cytoplasmic domain. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. nucleotide binding branching involved in blood vessel morphogenesis vasculogenesis response to hypoxia in utero embryonic development heart looping positive regulation of mesenchymal cell proliferation lens development in camera-type eye positive regulation of tolerance induction to self antigen positive regulation of B cell tolerance induction positive regulation of T cell tolerance induction outflow tract septum morphogenesis membranous septum morphogenesis outflow tract morphogenesis atrioventricular valve morphogenesis tricuspid valve morphogenesis cardiac left ventricle morphogenesis endocardial cushion fusion growth plate cartilage development growth plate cartilage chondrocyte growth protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type II protein binding ATP binding glycosaminoglycan binding cytoplasm cytosol plasma membrane integral component of plasma membrane caveola protein phosphorylation receptor-mediated endocytosis apoptotic process transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway common-partner SMAD protein phosphorylation Notch signaling pathway smoothened signaling pathway gastrulation pattern specification process brain development heart development embryo implantation aging response to nutrient negative regulation of cell proliferation response to mechanical stimulus response to glucose animal organ morphogenesis external side of plasma membrane cell surface response to organic substance regulation of gene expression positive regulation of epithelial cell migration positive regulation of epithelial to mesenchymal transition response to organic cyclic compound membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation growth factor binding cell differentiation lung development animal organ regeneration mitogen-activated protein kinase kinase kinase binding activation of protein kinase activity type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding embryonic hemopoiesis signaling receptor activity regulation of growth wound healing regulation of cell proliferation response to drug myeloid dendritic cell differentiation receptor complex positive regulation of skeletal muscle tissue regeneration response to estrogen membrane raft positive regulation of angiogenesis SMAD binding metal ion binding response to steroid hormone digestive tract development positive regulation of smooth muscle cell proliferation embryonic cranial skeleton morphogenesis transforming growth factor beta binding positive regulation of NK T cell differentiation cartilage development negative regulation of cardiac muscle cell proliferation pathway-restricted SMAD protein phosphorylation ventricular septum morphogenesis lung morphogenesis bronchus development bronchus morphogenesis trachea morphogenesis trachea formation mammary gland morphogenesis lung lobe morphogenesis response to cholesterol positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation inferior endocardial cushion morphogenesis lens fiber cell apoptotic process miRNA transport positive regulation of reactive oxygen species metabolic process positive regulation of CD4-positive, alpha-beta T cell proliferation cell proliferation involved in endocardial cushion morphogenesis superior endocardial cushion morphogenesis uc009ryt.1 uc009ryt.2 uc009ryt.3 uc009ryt.4 
ENSMUST00000035020.15 Eomes ENSMUST00000035020.15 eomesodermin, transcript variant 1 (from RefSeq NM_010136.4) ENSMUST00000035020.1 ENSMUST00000035020.10 ENSMUST00000035020.11 ENSMUST00000035020.12 ENSMUST00000035020.13 ENSMUST00000035020.14 ENSMUST00000035020.2 ENSMUST00000035020.3 ENSMUST00000035020.4 ENSMUST00000035020.5 ENSMUST00000035020.6 ENSMUST00000035020.7 ENSMUST00000035020.8 ENSMUST00000035020.9 EOMES_MOUSE NM_010136 O54839 Q3UPL1 Q52KJ1 Q8BN22 Q9JJL1 Q9QYG7 Tbr2 uc009rzq.1 uc009rzq.2 uc009rzq.3 uc009rzq.4 Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O54839-1; Sequence=Displayed; Name=2; IsoId=O54839-2; Sequence=VSP_038806; Expressed in CD8+ T-cells. Originally expressed in the trophoectoderm of the blastocyst and later in the extraembryonic ectoderm of the early post- implantation embryo. In the embryo proper, expressed in the posterior part of the epiblast. During gastrulation, extends distally into the primitive streak and nascent mesoderm. Also expressed in the developing forebrain and the olfactory lobes. Expressed at 12.5 dpc and 14.5 dpc in the forebrain. Up-regulated in CD8+ T-cells upon activation. Embryonic lethal due to peri-implantation defects. Mutant embryos arrest soon after implantation and fail to form organized embryonic or extraembryonic structures. Conditional mutants, with expression abrogated in the inner cell mass of embryos from early implantation stages onward, display gastrulation defects. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding endoderm formation mesoderm formation cell fate specification endodermal cell fate specification blastocyst development trophectodermal cell differentiation heart looping adaptive immune response CD8-positive, alpha-beta T cell differentiation involved in immune response immune system process DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development gastrulation brain development endoderm development anatomical structure morphogenesis cardioblast differentiation regulation of gene expression stem cell population maintenance olfactory bulb development cerebral cortex regionalization cerebral cortex neuron differentiation neurogenesis cell differentiation neuron differentiation interferon-gamma production skeletal muscle cell differentiation negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter mesendoderm development cell differentiation involved in embryonic placenta development mesodermal to mesenchymal transition involved in gastrulation molecular function regulator uc009rzq.1 uc009rzq.2 uc009rzq.3 uc009rzq.4 
ENSMUST00000035026.5 Trim42 ENSMUST00000035026.5 tripartite motif-containing 42 (from RefSeq NM_030219.2) E9QN55 ENSMUST00000035026.1 ENSMUST00000035026.2 ENSMUST00000035026.3 ENSMUST00000035026.4 NM_030219 Q9D2H5 TRI42_MOUSE uc009rdc.1 uc009rdc.2 Belongs to the TRIM/RBCC family. cellular_component biological_process zinc ion binding metal ion binding uc009rdc.1 uc009rdc.2 
ENSMUST00000035033.7 Copb2 ENSMUST00000035033.7 COPI coat complex subunit beta 2 (from RefSeq NM_015827.2) COPB2_MOUSE ENSMUST00000035033.1 ENSMUST00000035033.2 ENSMUST00000035033.3 ENSMUST00000035033.4 ENSMUST00000035033.5 ENSMUST00000035033.6 NM_015827 O55029 Q3U5Z9 uc009rdm.1 uc009rdm.2 uc009rdm.3 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP- dependent manner. Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Probably interacts with PEX11A. Interacts with SCYL1. Interacts with JAGN1 (By similarity). Cytoplasm, cytosol Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi. The knockout of the gene results in early embryonic lethality with no viable embryos recovered at 12.5 dpc. Belongs to the WD repeat COPB2 family. Golgi membrane protein kinase C binding structural molecule activity cytoplasm Golgi apparatus cytosol intracellular protein transport ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER intra-Golgi vesicle-mediated transport protein transport membrane vesicle-mediated transport membrane coat COPI vesicle coat COPI-coated vesicle membrane cytoplasmic vesicle toxin transport uc009rdm.1 uc009rdm.2 uc009rdm.3 
ENSMUST00000035034.10 Mrps22 ENSMUST00000035034.10 mitochondrial ribosomal protein S22 (from RefSeq NM_025485.3) ENSMUST00000035034.1 ENSMUST00000035034.2 ENSMUST00000035034.3 ENSMUST00000035034.4 ENSMUST00000035034.5 ENSMUST00000035034.6 ENSMUST00000035034.7 ENSMUST00000035034.8 ENSMUST00000035034.9 NM_025485 Q3U3T2 Q8VDG9 Q9CXW2 Q9D185 RT22_MOUSE Rpms22 uc009rdn.1 uc009rdn.2 uc009rdn.3 uc009rdn.4 uc009rdn.5 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Heterozygous MRPS22 knockout mice are fertile and show no overt abnormalities. Homozygous MRPS22 knockout results in embryonic lethality. Belongs to the mitochondrion-specific ribosomal protein mS22 family. Sequence=AAH21882.1; Type=Erroneous initiation; Evidence=; structural constituent of ribosome mitochondrion mitochondrial small ribosomal subunit ribosome biological_process uc009rdn.1 uc009rdn.2 uc009rdn.3 uc009rdn.4 uc009rdn.5 
ENSMUST00000035037.14 Pik3cb ENSMUST00000035037.14 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (from RefSeq NM_029094.3) ENSMUST00000035037.1 ENSMUST00000035037.10 ENSMUST00000035037.11 ENSMUST00000035037.12 ENSMUST00000035037.13 ENSMUST00000035037.2 ENSMUST00000035037.3 ENSMUST00000035037.4 ENSMUST00000035037.5 ENSMUST00000035037.6 ENSMUST00000035037.7 ENSMUST00000035037.8 ENSMUST00000035037.9 NM_029094 PK3CB_MOUSE Q3U4Q1 Q8BTI9 uc009rdv.1 uc009rdv.2 uc009rdv.3 uc009rdv.4 Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G- protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Has also a protein kinase activity showing autophosphorylation. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+); Xref=Rhea:RHEA:21292, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57836, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.153; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21293; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero- 3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo- inositol 3,4,5-triphosphate) + ADP + H(+); Xref=Rhea:RHEA:43396, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77137, ChEBI:CHEBI:83243, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43397; Evidence=; Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export (By similarity). Part of a complex with PIK3R1 and PTEN (By similarity). Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions (By similarity). Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4. Interacts with BECN1, ATG14 and RAB5A. Q8BTI9; P26450: Pik3r1; NbExp=5; IntAct=EBI-644672, EBI-641764; Cytoplasm Nucleus Note=Interaction with PIK3R2 is required for nuclear localization and export. The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival (By similarity). Phosphorylation at Ser-1064 down-regulates lipid kinase activity. Autophosphorylation at Ser-1064 negatively regulates the phosphatidylinositol-4,5-bisphosphate 3-kinase activity. Mice have defects in autophagosome formation. Have normal bleeding time but are resistant to thrombosis after arterial injury. Mice fail to induce tumors in a model of prostate tumor formation induced by Pten loss. Belongs to the PI3/PI4-kinase family. nucleotide binding endothelial cell proliferation regulation of cell-matrix adhesion protein binding ATP binding nucleus nucleolus cytoplasm cytosol plasma membrane phosphatidylinositol 3-kinase complex cellular calcium ion homeostasis endocytosis autophagy cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules response to wounding positive regulation of gene expression phosphatidylinositol 3-kinase signaling membrane kinase activity 1-phosphatidylinositol-3-kinase activity phosphorylation transferase activity platelet activation midbody brush border membrane positive regulation of neutrophil apoptotic process phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity phosphatidylinositol-3-phosphate biosynthetic process embryonic cleavage insulin receptor substrate binding phosphatidylinositol phosphorylation phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphatidylinositol-mediated signaling phosphatidylinositol-3,4-bisphosphate 5-kinase activity angiogenesis involved in wound healing uc009rdv.1 uc009rdv.2 uc009rdv.3 uc009rdv.4 
ENSMUST00000035038.8 Faim ENSMUST00000035038.8 Fas apoptotic inhibitory molecule, transcript variant 2 (from RefSeq NM_011810.3) ENSMUST00000035038.1 ENSMUST00000035038.2 ENSMUST00000035038.3 ENSMUST00000035038.4 ENSMUST00000035038.5 ENSMUST00000035038.6 ENSMUST00000035038.7 FAIM1_MOUSE Faim1 NM_011810 Q9DAK6 Q9WUD8 uc009rdt.1 uc009rdt.2 uc009rdt.3 uc009rdt.4 Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells. Cytoplasm Widely expressed, with the highest levels in brain, thymus, kidney, and spleen. Belongs to the FAIM1 family. cytoplasm apoptotic process I-kappaB kinase/NF-kappaB signaling negative regulation of apoptotic process positive regulation of neurogenesis negative regulation of extrinsic apoptotic signaling pathway via death domain receptors uc009rdt.1 uc009rdt.2 uc009rdt.3 uc009rdt.4 
ENSMUST00000035043.12 Armc8 ENSMUST00000035043.12 armadillo repeat containing 8, transcript variant 1 (from RefSeq NM_028768.3) Armc8 ENSMUST00000035043.1 ENSMUST00000035043.10 ENSMUST00000035043.11 ENSMUST00000035043.2 ENSMUST00000035043.3 ENSMUST00000035043.4 ENSMUST00000035043.5 ENSMUST00000035043.6 ENSMUST00000035043.7 ENSMUST00000035043.8 ENSMUST00000035043.9 G3X920 G3X920_MOUSE NM_028768 uc009ref.1 uc009ref.2 uc009ref.3 uc009ref.4 ubiquitin ligase complex nucleus cytoplasm uc009ref.1 uc009ref.2 uc009ref.3 uc009ref.4 
ENSMUST00000035045.15 Mras ENSMUST00000035045.15 muscle and microspikes RAS (from RefSeq NM_008624.3) ENSMUST00000035045.1 ENSMUST00000035045.10 ENSMUST00000035045.11 ENSMUST00000035045.12 ENSMUST00000035045.13 ENSMUST00000035045.14 ENSMUST00000035045.2 ENSMUST00000035045.3 ENSMUST00000035045.4 ENSMUST00000035045.5 ENSMUST00000035045.6 ENSMUST00000035045.7 ENSMUST00000035045.8 ENSMUST00000035045.9 Mras NM_008624 Q3TPX5 Q3TPX5_MOUSE uc009rec.1 uc009rec.2 uc009rec.3 nucleotide binding GTPase activity GTP binding signal transduction membrane GTP-dependent protein binding uc009rec.1 uc009rec.2 uc009rec.3 
ENSMUST00000035048.12 Cldn18 ENSMUST00000035048.12 claudin 18, transcript variant A1.1 (from RefSeq NM_019815.3) CLD18_MOUSE ENSMUST00000035048.1 ENSMUST00000035048.10 ENSMUST00000035048.11 ENSMUST00000035048.2 ENSMUST00000035048.3 ENSMUST00000035048.4 ENSMUST00000035048.5 ENSMUST00000035048.6 ENSMUST00000035048.7 ENSMUST00000035048.8 ENSMUST00000035048.9 NM_019815 P56857 Q91ZY9 Q91ZZ0 Q91ZZ1 uc009rep.1 uc009rep.2 uc009rep.3 uc009rep.4 uc009rep.5 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is a downstream target gene regulated by the T/EBP/NKX2.1 homeodomain transcription factor. Four alternatively spliced transcript variants resulted from alternative promoters and alternative splicing have been identified, which encode two lung-specific isoforms and two stomach-specific isoforms respectively. This gene is also expressed in colons, inner ear and skin, and its expression is increased in both experimental colitis and ulcerative colitis. [provided by RefSeq, Aug 2010]. Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (PubMed:24588076). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (PubMed:24787463). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (PubMed:29400695). Acts as a negative regulator of RANKL- induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (PubMed:22437732). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (PubMed:23299504). [Isoform A1.1]: Involved in the maintenance of homeostasis of the alveolar microenvironment via regulation of pH and subsequent T- cell activation in the alveolar space, is therefore indirectly involved in limiting C. neoformans infection. [Isoform A2.1]: Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification. Interacts with TJP2/ZO-2 (PubMed:22437732). Interacts with TJP1/ZO-1 (PubMed:29400695). Interacts with YAP1 (phosphorylated); the interaction sequesters YAP1 away from the nucleus and thereby restricts transcription of YAP1 target genes (PubMed:29400695). Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Note=Localizes to tight junctions in epithelial cells. [Isoform A1.1]: Cell junction, tight junction [Isoform A2.1]: Cell junction, tight junction Lateral cell membrane Event=Alternative splicing; Named isoforms=4; Name=A1.1; Synonyms=Lung-type ; IsoId=P56857-1; Sequence=Displayed; Name=A1.2; IsoId=P56857-2; Sequence=VSP_001104, VSP_001105; Name=A2.1; Synonyms=Stomach-type ; IsoId=P56857-3; Sequence=VSP_001103; Name=A2.2; IsoId=P56857-4; Sequence=VSP_001103, VSP_001104, VSP_001105; Expressed in the lung (at protein level). [Isoform A1.1]: Expressed in lung (PubMed:11585919, PubMed:22437732). Expressed in the stomach (PubMed:22079592). [Isoform A1.2]: Expressed in lung. [Isoform A2.1]: Expressed in stomach (PubMed:11585919, PubMed:22079592, PubMed:22437732). Expressed in bone (PubMed:22437732). [Isoform A2.2]: Expressed in stomach. Expressed in the lungs from 19 dpc, expression is increased at birth and at four weeks of age. Induced by 17-beta-estradiol in bone marrow stromal cells, osteoblasts and osteoclasts. Parenchymal expansion phenotype and overall lung enlargement evident from 18 days post-conception (dpc), as a result of increased lung cellularity, airspace enlargement and increase in the number of AT2 cells in the lung alveolar compartments (PubMed:29400695). Increase in AT2 cells in S and G2/M phase of the cell cycle with no change in low levels of apoptosis in the lungs (PubMed:29400695). Increase in bronchoalveolar lavage fluid leakage as a result of alveolar epithelial cell injury at P3 and four weeks of age, resulting in an increase in AT2 cells in the lungs by four weeks of age (PubMed:24787463). Increase in expression of Cldn3 and Cldn4 in lungs at P7 (PubMed:24787463). Fixed alveolar permeability defect and dysregulation of genes involved in lung development in lung tissue, including Areg, Shh, Eln, Vegfa, Fgfr4, and Adm from 4 weeks of age (PubMed:24787463). Impaired alveolarization and decreased lung surface area at four weeks of age (PubMed:24787463). Membrane ruffling and splaying is evident at AT1-AT1 cell junctions at 8 weeks of age (PubMed:24787463). Increase in alveolar fluid clearance and lung permeability (PubMed:24588076). Increase in sodium/potassium- transporting ATPase activity in lungs, accompanied by an increase in Atp1b1 subunit expression, and decreases in Atp1a2, Atp1b3 and Atp1b2 subunit expression (PubMed:24588076). Increase in expression of Cldn3 and Cldn4 in lung tissues with a decrease in Ocln and Egr1 expression in lung tissues (PubMed:24588076). Increase in separation distance between Tjp1/Zo-1 in adjacent cells suggesting tight junction separation (PubMed:24588076). Cytoskeleton rearrangements as evidenced by increased F-actin localization to the plasma membrane and perinuclear actin aggregates with projected radial fibers to the plasma membrane (PubMed:24588076). Decrease in sensitivity to lung injury in response to ventilator-induced lung injury (PubMed:24588076). Increased nuclear localization and protein mobility of Yap1 while phosphorylated Yap1 abundance is decreased in AT2 cells, this results in an increase in Yap1-target genes such as Ccnd1, Areg, Cdk6 and Ccn2/Ctgf at two months of age (PubMed:29400695). Enlargement of the stomach due to increase in gastric mucosal thickness from 2 months of age (PubMed:29400695). Enlargement of the duodenum and kidney from 2 months of age (PubMed:29400695). Histological abnormalities in the gastric mucosa including inflammatory infiltrates and a decrease in the number of well-differentiated gastric chief cells and parietal cells (PubMed:22437732). Reduced total body bone mineral content, total body bone mineral density (BMD), cortical bone thickness, vertebra BMD and femur BMD by 20-25% from 4 to 26 weeks of age (PubMed:22437732, PubMed:23299504). Reduced trabecular bone, trabecular thickness and trabecular number decreased by 50%, whereas trabecular spacing is increased by 50% from 4 to 26 weeks of age (PubMed:22437732). Significant increase in osteoclastogenesis, osteoclast number and number of nuclei in osteoclasts on the surface of the trabecular bone of the proximal tibia (PubMed:22437732). Decrease in bone mass density in the femur, lumbar and whole body (PubMed:22437732). Skeletal defects and osteoclast levels were exacerbated significantly by a calcium depleted diet (PubMed:22437732). Reduction in bone volume to total volume ratio and osteoclast surface to bone surface ratio at 14 weeks of age (PubMed:23299504). Protection against ovariectomy-induced loss of total body, femur and lumbar bone mass density (PubMed:23299504). A 68% increase in incidence of tumors in lungs between 18 and 20 months of age, tumors develop after 10 months of age (PubMed:29400695). Tumors are of a AT2 cell-derived lineage, typically adenocarcinomas with associated alveolar mononuclear cells (PubMed:29400695). [Isoform A1.1]: Defective alveolar formation and increased alveolar macrophage counts evident at 6 weeks of age (PubMed:34702961). Increase in C. neoformans fungal burdens in bronchoalveolar lavage fluids (BALF), lung tissue and alveolar space from 1 day post-infection to 14 days post-infection (PubMed:34702961). Increase in multiplication of C. neoformans and poor granulomatous responses in the lung at 14 days post-infection with overall higher infection burdens in the brain and lungs to 28 days post-infection (PubMed:34702961). Increase in neutrophils, alveolar macrophages, inflammatory monocytes, natural killer cells, CD4-positive T-cells, CD8-positive T-cells and natural killer T-cells in BALF 3 days post-C. neoformans infection (PubMed:34702961). Decrease in IFNG in BALF on days 3 and 7 post-infection, similarly a decrease in Il4 and Il13 in BALF on day 14 and in the lungs on day 3 and day 14 post-infection (PubMed:34702961). Decrease in Il17a in BALF on day 7 and in the lungs on day 14 post-infection (PubMed:34702961). Increase in K(+) ion concentration in BALF, with a decrease in pH which persists 7 days post-infection, resulting in the increased replication of C. neoformans (PubMed:34702961). [Isoform A2.1]: 100% incidence of chronic gastritis with atypical distribution of cells in the gastric gland, including fewer parietal and chief cells that are replaced by metaplastic cells with dilated gland lumina (PubMed:22079592). Lack of increase in stomach lumen acidification with age (PubMed:22079592). Lack of sensitivity to gastric acidity and an increase in ion permeability of the gastric paracellular barrier (PubMed:22079592). Spasmolytic polypeptide-expressing metaplasia cells are dominant in the stomach in place of well-differentiated parietal cells and chief cells (PubMed:22079592). Abundant inflammatory cells in the submucosal region (PubMed:22079592). Slight decrease in the localization of Cldn18 isoform A1.1 at tight junctions in the gastric superficial mucous epithelial cells (PubMed:22079592). Upper apical layer of tight junctions in the stomach missing resulting in a decrease in tight junction width (PubMed:22079592). Increase in proinflammatory markers Il1a and Tnf/Tnf-a, the chemoattractant Cxcl1/Kc and prostaglandin E2 inflammatory marker Ptgs2/Cox2 in gastric tissue (PubMed:22079592). May act as a tumor suppressor, inhibiting the development of AT2 cell-derived lung tumors. Belongs to the claudin family. structural molecule activity protein binding plasma membrane bicellular tight junction membrane integral component of membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding response to ethanol negative regulation of bone resorption digestive tract development TNFSF11-mediated signaling pathway negative regulation of protein localization to nucleus negative regulation of osteoclast development uc009rep.1 uc009rep.2 uc009rep.3 uc009rep.4 uc009rep.5 
ENSMUST00000035053.12 Nme6 ENSMUST00000035053.12 NME/NM23 nucleoside diphosphate kinase 6, transcript variant 1 (from RefSeq NM_018757.2) ENSMUST00000035053.1 ENSMUST00000035053.10 ENSMUST00000035053.11 ENSMUST00000035053.2 ENSMUST00000035053.3 ENSMUST00000035053.4 ENSMUST00000035053.5 ENSMUST00000035053.6 ENSMUST00000035053.7 ENSMUST00000035053.8 ENSMUST00000035053.9 NDK6_MOUSE NM_018757 O88425 Q99M53 uc009rst.1 uc009rst.2 uc009rst.3 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence= Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the NDK family. nucleotide binding nucleoside diphosphate kinase activity ATP binding mitochondrion nucleoside diphosphate phosphorylation GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process nucleotide metabolic process kinase activity phosphorylation transferase activity negative regulation of cell growth negative regulation of mitotic nuclear division metal ion binding uc009rst.1 uc009rst.2 uc009rst.3 
ENSMUST00000035055.15 Map4 ENSMUST00000035055.15 microtubule-associated protein 4, transcript variant 10 (from RefSeq NM_001420117.1) ENSMUST00000035055.1 ENSMUST00000035055.10 ENSMUST00000035055.11 ENSMUST00000035055.12 ENSMUST00000035055.13 ENSMUST00000035055.14 ENSMUST00000035055.2 ENSMUST00000035055.3 ENSMUST00000035055.4 ENSMUST00000035055.5 ENSMUST00000035055.6 ENSMUST00000035055.7 ENSMUST00000035055.8 ENSMUST00000035055.9 MAP4_MOUSE Mtap4 NM_001420117 P27546 Q05BJ2 Q3UIS2 Q3UUH5 Q3UY36 Q7TPC6 Q7TPD4 Q80YQ5 Q8CFP5 uc009rta.1 uc009rta.2 uc009rta.3 uc009rta.4 uc009rta.5 Non-neuronal microtubule-associated protein. Promotes microtubule assembly. Interacts with SEPTIN2; this interaction impedes tubulin- binding. Interacts with TRAF3IP1 (PubMed:26487268). Interacts with KNSTRN (By similarity). Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center Note=Recruitment to microtubule is inhibited by microtubules polyglutamylation. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P27546-1; Sequence=Displayed; Name=2; IsoId=P27546-2; Sequence=VSP_026097; Name=3; IsoId=P27546-3; Sequence=VSP_026095, VSP_026097; Name=4; IsoId=P27546-4; Sequence=VSP_026089, VSP_026090, VSP_026091, VSP_026092, VSP_026093, VSP_026094, VSP_026095, VSP_026096, VSP_026097; Testis, striated and cardiac muscle. Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-760 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 4 is phosphorylated on Ser-333 and Ser-334 (By similarity). Sequence=AAH42645.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE27434.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; microtubule cytoskeleton organization protein binding cytoplasm cytosol cytoskeleton microtubule plasma membrane axoneme mitotic spindle organization microtubule binding postsynaptic density microtubule cytoskeleton tubulin binding axon neuron projection development neuron projection microtubule sliding establishment of spindle orientation cell division mitotic spindle negative regulation of non-motile cilium assembly uc009rta.1 uc009rta.2 uc009rta.3 uc009rta.4 uc009rta.5 
ENSMUST00000035058.10 Cspg5 ENSMUST00000035058.10 chondroitin sulfate proteoglycan 5, transcript variant 2 (from RefSeq NM_001166273.1) CSPG5_MOUSE Caleb E9QN54 ENSMUST00000035058.1 ENSMUST00000035058.2 ENSMUST00000035058.3 ENSMUST00000035058.4 ENSMUST00000035058.5 ENSMUST00000035058.6 ENSMUST00000035058.7 ENSMUST00000035058.8 ENSMUST00000035058.9 NM_001166273 Ngc Q71M36 Q71M37 Q7TNT8 Q8BPJ5 Q9QY32 uc009rts.1 uc009rts.2 uc009rts.3 uc009rts.4 This gene encodes a chondroitin sulfate proteoglycan. The encoded protein has been termed a 'part-time' proteoglycan, as chondroitin sulfate chains appear to be attached to the protein in the developing but not the adult cerebellum and retina. It is thought that this protein plays roles in dendrite branching and synapse formation. [provided by RefSeq, Oct 2009]. May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC. Interacts with MDK; this interaction is independent of the presence of chondroitin sulfate chains and promotes elongation of oligodendroglial precursor-like cells (By similarity). Cell membrane ; Single-pass type I membrane protein Synaptic cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Golgi apparatus membrane ingle-pass type I membrane protein Cell surface Secreted Note=Partially enriched in lipid rafts (By similarity). Also detected in the endoplasmic reticulum and the Golgi (PubMed:10617623). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=NGC-III; IsoId=Q71M36-1; Sequence=Displayed; Name=2; Synonyms=NGC-I; IsoId=Q71M36-2; Sequence=VSP_015763; Name=3; Synonyms=NGC-II; IsoId=Q71M36-3; Sequence=VSP_015762, VSP_015763; Name=4; IsoId=Q71M36-4; Sequence=VSP_015764; Expressed in olfactory bulb, hippocampus, brain stem, spinal cord, cerebrum and cerebellum. Expressed by Purkinje cells in the cerebellum (at protein level). Expressed in immature and mature cerebellum (isoform 1, isoform 2 and isoform 3). The proteoglycan form decreases from birth to adulthood in the cerebellum concomitant with non-proteoglycan form increase. In the cerebrum the maximum of expression of the proteoglycan is detected 15 days after birth and then decreases gradually to reach half-level at adulthood (at protein level). N-glycosylated. O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissue maturation. In the cerebellum the 2 forms coexist while in the cerebrum the proteoglycan form is predominant. Phosphorylated; in intracellular and extracellular parts. Altered synaptic transmission at early developmental stages. Different forms of various molecular weight have been observed. Such forms are possibly due to different levels of glycosylation, phosphorylation and/or protein cleavage. [Isoform 2]: Major isoform. Sequence=AAQ04778.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC35578.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane cytoskeleton organization multicellular organism development nervous system development cell surface membrane integral component of membrane cell differentiation Golgi-associated vesicle membrane regulation of growth modulation of synaptic transmission glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane trans-synaptic signalling, modulating synaptic transmission positive regulation of substrate adhesion-dependent cell spreading regulation of synaptic vesicle exocytosis uc009rts.1 uc009rts.2 uc009rts.3 uc009rts.4 
ENSMUST00000035061.9 Ngp ENSMUST00000035061.9 neutrophilic granule protein (from RefSeq NM_008694.2) ENSMUST00000035061.1 ENSMUST00000035061.2 ENSMUST00000035061.3 ENSMUST00000035061.4 ENSMUST00000035061.5 ENSMUST00000035061.6 ENSMUST00000035061.7 ENSMUST00000035061.8 NGP_MOUSE NM_008694 Ngp O08692 Q61903 uc009rtz.1 uc009rtz.2 uc009rtz.3 uc009rtz.4 Acts as an inhibitor of cathepsin B (CTSB) activity. Plays a role as a negative regulator of tumor vascular development, cell invasion and metastasis. Monomer. Homodimer; disulfide-linked. Secreted Cytoplasmic granule Note=Localizes in cytoplasmic granules of neutrophilic precursors (PubMed:8749713). Expressed in myeloid bone marrow cells. Expressed in neutrophilic precursors (at protein level) (PubMed:8749713). Expressed in myeloid bone marrow cells (PubMed:21518852). Up-regulated by CCAAT/enhancer-binding proteins CEBPA and CEBPE and transcription factor SPI1 (at protein level) (PubMed:12515729). Down-regulated in malignant tumor conditioned medium (PubMed:21518852). Up-regulated during early bone marrow differentiation by the granulocyte-macrophage colony-stimulating factor CSF2 and down-regulated during granulocytic maturation (PubMed:8749713). Belongs to the cathelicidin family. cysteine-type endopeptidase inhibitor activity extracellular region extracellular space defense response negative regulation of peptidase activity negative regulation of endopeptidase activity negative regulation of angiogenesis peptidase inhibitor activity cytoplasmic vesicle specific granule negative regulation of lymphangiogenesis uc009rtz.1 uc009rtz.2 uc009rtz.3 uc009rtz.4 
ENSMUST00000035065.9 Ptgs2 ENSMUST00000035065.9 prostaglandin-endoperoxide synthase 2 (from RefSeq NM_011198.5) Cox-2 Cox2 ENSMUST00000035065.1 ENSMUST00000035065.2 ENSMUST00000035065.3 ENSMUST00000035065.4 ENSMUST00000035065.5 ENSMUST00000035065.6 ENSMUST00000035065.7 ENSMUST00000035065.8 NM_011198 PGH2_MOUSE Pghs-b Ptgs2 Q05769 Q543K3 Tis10 uc007cxv.1 uc007cxv.2 uc007cxv.3 uc007cxv.4 This gene encodes an enzyme that is a member of the prostaglandin G/H synthase family. The encoded protein converts arachidonic acid to prostaglandin endoperoxide H2 which is a key enzymatic step in prostaglandin biosynthesis. This gene is the inducible prostaglandin G/H synthase family member that is upregulated during inflammation. Aberrant regulation of this gene is associated with cancer progression in several tissues and an increased risk of cardiovascular events. This gene is the target of many non-steroidal anti-inflammatory drugs. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M88242.1, AK144726.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response (PubMed:22942274, PubMed:12925531, PubMed:20463020, PubMed:20810665, PubMed:21489986). The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:22942274, PubMed:12925531, PubMed:20463020, PubMed:20810665, PubMed:21489986). Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3- series prostaglandins (By similarity). In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids (By similarity). Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response (By similarity). Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols (By similarity). Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further metabolized by ALOX5 and LTA4H to generate 18S-RvE1 and 18S-RvE2. In vascular endothelial cells, converts docosapentaenoate (DPA, C22:5(n-3)) to 13R-HDPA, a precursor for 13-series resolvins (RvTs) shown to activate macrophage phagocytosis during bacterial infection (By similarity). In activated leukocytes, contributes to oxygenation of hydroxyeicosatetraenoates (HETE) to diHETES (5,15-diHETE and 5,11-diHETE) (By similarity). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)- octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)- octadecadienoate) its major products (By similarity). During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs) 15R-lipoxin A4 that regulates phagocytic microglia (PubMed:29662056). Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2; Xref=Rhea:RHEA:23728, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:32395, ChEBI:CHEBI:57405; EC=1.14.99.1; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23729; Evidence= Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2; Xref=Rhea:RHEA:42596, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:82629; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42597; Evidence=; Reaction=AH2 + prostaglandin G2 = A + H2O + prostaglandin H2; Xref=Rhea:RHEA:42600, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:57405, ChEBI:CHEBI:82629; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42601; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3; Xref=Rhea:RHEA:50444, ChEBI:CHEBI:15379, ChEBI:CHEBI:58562, ChEBI:CHEBI:133133; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50445; Evidence=; Reaction=AH2 + prostaglandin G3 = A + H2O + prostaglandin H3; Xref=Rhea:RHEA:50448, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:133133, ChEBI:CHEBI:133134; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50449; Evidence=; Reaction=(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1; Xref=Rhea:RHEA:50424, ChEBI:CHEBI:15379, ChEBI:CHEBI:71589, ChEBI:CHEBI:133084; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50425; Evidence=; Reaction=AH2 + prostaglandin G1 = A + H2O + prostaglandin H1; Xref=Rhea:RHEA:50432, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:90793, ChEBI:CHEBI:133084; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50433; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3- phosphoethanolamine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3- phosphoethanolamine; Xref=Rhea:RHEA:54204, ChEBI:CHEBI:15379, ChEBI:CHEBI:76091, ChEBI:CHEBI:138098; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54205; Evidence=; Reaction=2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O; Xref=Rhea:RHEA:54208, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:138098, ChEBI:CHEBI:138099; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54209; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:54212, ChEBI:CHEBI:15379, ChEBI:CHEBI:76079, ChEBI:CHEBI:138100; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54213; Evidence=; Reaction=2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2- (prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O; Xref=Rhea:RHEA:54216, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:138100, ChEBI:CHEBI:138101; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54217; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O; Xref=Rhea:RHEA:48856, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:57409, ChEBI:CHEBI:57446; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48857; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn- glycero-3-phosphocholine + A + H2O; Xref=Rhea:RHEA:53684, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:76079, ChEBI:CHEBI:137584; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53685; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn- glycero-3-phosphocholine + A + H2O; Xref=Rhea:RHEA:53680, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:76079, ChEBI:CHEBI:137583; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53681; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn- glycero-3-phosphocholine + A + H2O; Xref=Rhea:RHEA:53676, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:76079, ChEBI:CHEBI:137582; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53677; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)- octadecadienoate + A + H2O; Xref=Rhea:RHEA:50864, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:133820; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50865; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)- octadecadienoate + A + H2O; Xref=Rhea:RHEA:50860, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:133819; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50861; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy- (5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O; Xref=Rhea:RHEA:50856, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:32395, ChEBI:CHEBI:78837; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50857; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy- (5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O; Xref=Rhea:RHEA:50852, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:32395, ChEBI:CHEBI:78836; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50853; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)- hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O; Xref=Rhea:RHEA:50848, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:58562, ChEBI:CHEBI:90820; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50849; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)- hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O; Xref=Rhea:RHEA:50200, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:58562, ChEBI:CHEBI:132083; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50201; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)- hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O; Xref=Rhea:RHEA:48836, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:58562, ChEBI:CHEBI:90818; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48837; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)- hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O; Xref=Rhea:RHEA:48840, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:58562, ChEBI:CHEBI:90819; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48841; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)- hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O; Xref=Rhea:RHEA:50196, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:58562, ChEBI:CHEBI:132087; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50197; Evidence=; Reaction=(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R- hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O; Xref=Rhea:RHEA:48852, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:77224, ChEBI:CHEBI:90824; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48853; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13- hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O; Xref=Rhea:RHEA:48820, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:77016, ChEBI:CHEBI:90815; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48821; Evidence=; Reaction=(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O; Xref=Rhea:RHEA:48812, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:90632, ChEBI:CHEBI:90812; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48813; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R- hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O; Xref=Rhea:RHEA:48816, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:77016, ChEBI:CHEBI:90814; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48817; Evidence=; Reaction=(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O; Xref=Rhea:RHEA:48808, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:90632, ChEBI:CHEBI:90813; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48809; Evidence=; Reaction=(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O; Xref=Rhea:RHEA:48804, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:90632, ChEBI:CHEBI:90810; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48805; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 = 2- glyceryl-prostaglandin G2; Xref=Rhea:RHEA:45288, ChEBI:CHEBI:15379, ChEBI:CHEBI:52392, ChEBI:CHEBI:85165; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45289; Evidence=; Reaction=2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O; Xref=Rhea:RHEA:45292, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:85165, ChEBI:CHEBI:85166; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45293; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy- (5Z,8Z,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:42284, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:82626; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42285; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11R-hydroperoxy- (5Z,8Z,12E,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:42280, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:82628; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42281; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)- octadecadienoate + A + H2O; Xref=Rhea:RHEA:75447, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:77895; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75448; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)- octadecadienoate + A + H2O; Xref=Rhea:RHEA:75459, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:77852; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75460; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)- octadecadienoate + A + H2O; Xref=Rhea:RHEA:75451, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:90850; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75452; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)- octadecadienoate + A + H2O; Xref=Rhea:RHEA:75455, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:136655; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75456; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence= Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit. Inhibited by the nonsteroidal anti-inflammatory drugs aspirin, naproxen, diclofenac, meclofenamic acid, indomethacin and their analogs. Lipid metabolism; prostaglandin biosynthesis. Homodimer. Q05769; Q9Z0J4: Nos1; NbExp=4; IntAct=EBI-298933, EBI-397596; Microsome membrane ; Peripheral membrane protein. Endoplasmic reticulum membrane ; Peripheral membrane protein. Nucleus inner membrane ; Peripheral membrane protein. Nucleus outer membrane ; Peripheral membrane protein. Note=Detected on the lumenal side of the endoplasmic reticulum and nuclear envelope. Following colon injury, expressed in the wound bed mesenchyme during the first phase of repair, probably by colonic mesenchymal stem cells (at protein level). During colonic wound repair, highly up-regulated (more than 1600-fold) in the mesenchyme of the wound bed 2 days after injury as compared to uninjured mucosa. Further increase in expression is observed at day 4 following injury (close to 2200-fold). Down- regulated at day 6 (only 93-fold increase as compared to uninjured mucosa). By cytokines and mitogens. S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S- nitrosylation may take place on different Cys residues in addition to Cys-526. Acetylated at Ser-565 by SPHK1. During neuroinflammation, acetylation by SPHK1 promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia. Mutant mice exhibit defects in colonic mucosal wound repair. The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site. Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine- tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation. PTGS1 and PTGS2 are the targets of nonsteroidal anti- inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration. Belongs to the prostaglandin G/H synthase family. prostaglandin biosynthetic process angiogenesis peroxidase activity prostaglandin-endoperoxide synthase activity protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane caveola lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process inflammatory response response to oxidative stress embryo implantation aging learning memory regulation of blood pressure positive regulation of cell proliferation negative regulation of cell proliferation response to radiation response to fructose response to organic substance response to manganese ion response to lithium ion response to organonitrogen compound positive regulation of vascular endothelial growth factor production positive regulation of cell death response to organic cyclic compound membrane oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen sensory perception of pain cyclooxygenase pathway enzyme binding heme binding keratinocyte differentiation bone mineralization ovulation organelle membrane positive regulation of prostaglandin biosynthetic process positive regulation of fever generation positive regulation of synaptic plasticity negative regulation of synaptic transmission, dopaminergic response to estradiol response to lipopolysaccharide macromolecular complex positive regulation of peptidyl-serine phosphorylation response to vitamin D response to cytokine cellular response to heat response to tumor necrosis factor cellular response to UV maintenance of permeability of blood-brain barrier regulation of cell proliferation positive regulation of protein import into nucleus response to drug hair cycle protein homodimerization activity neuron projection positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process intracellular membrane-bounded organelle positive regulation of nitric oxide biosynthetic process negative regulation of cell cycle positive regulation of vasoconstriction negative regulation of smooth muscle contraction positive regulation of smooth muscle contraction decidualization metal ion binding positive regulation of smooth muscle cell proliferation brown fat cell differentiation dioxygenase activity response to glucocorticoid negative regulation of calcium ion transport positive regulation of synaptic transmission, glutamatergic oxidation-reduction process response to fatty acid cellular response to mechanical stimulus cellular response to lead ion cellular response to ATP cellular response to hypoxia cellular response to non-ionic osmotic stress cellular response to fluid shear stress positive regulation of transforming growth factor beta production positive regulation of cell migration involved in sprouting angiogenesis positive regulation of fibroblast growth factor production positive regulation of brown fat cell differentiation positive regulation of platelet-derived growth factor production cellular oxidant detoxification negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress response to angiotensin uc007cxv.1 uc007cxv.2 uc007cxv.3 uc007cxv.4 
ENSMUST00000035069.14 Nradd ENSMUST00000035069.14 neurotrophin receptor associated death domain (from RefSeq NM_026012.2) ENSMUST00000035069.1 ENSMUST00000035069.10 ENSMUST00000035069.11 ENSMUST00000035069.12 ENSMUST00000035069.13 ENSMUST00000035069.2 ENSMUST00000035069.3 ENSMUST00000035069.4 ENSMUST00000035069.5 ENSMUST00000035069.6 ENSMUST00000035069.7 ENSMUST00000035069.8 ENSMUST00000035069.9 NM_026012 NRADD_MOUSE Q3TVC1 Q8CJ26 uc009ruk.1 uc009ruk.2 uc009ruk.3 Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR. Interacts with NGFR. Interacts with NTRK1. Interacts with SORT1. Q8CJ26; Q6PHU5: Sort1; NbExp=5; IntAct=EBI-6985725, EBI-6985663; Cell membrane; Single-pass type III membrane protein. Nucleus. Note=Proteolytic processing gives rise to an intracellular domain that translocates to the nucleus. Detected in lung and testis. in utero embryonic development death receptor activity neurotrophin p75 receptor binding protein binding nucleus nuclear envelope lumen plasma membrane apoptotic process signal transduction Rho protein signal transduction brain development cell surface positive regulation of cell death coreceptor activity membrane integral component of membrane lamellipodium neuron projection membrane cell body membrane nerve growth factor binding uc009ruk.1 uc009ruk.2 uc009ruk.3 
ENSMUST00000035075.13 Cripto ENSMUST00000035075.13 cripto, EGF-CFC family member (from RefSeq NM_011562.2) ENSMUST00000035075.1 ENSMUST00000035075.10 ENSMUST00000035075.11 ENSMUST00000035075.12 ENSMUST00000035075.2 ENSMUST00000035075.3 ENSMUST00000035075.4 ENSMUST00000035075.5 ENSMUST00000035075.6 ENSMUST00000035075.7 ENSMUST00000035075.8 ENSMUST00000035075.9 NM_011562 P51865 Q7TQ06 TDGF1_MOUSE Tdgf1 uc009rvg.1 uc009rvg.2 uc009rvg.3 GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by Tmem8a modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. P51865; O13144: CHUNP6892; Xeno; NbExp=2; IntAct=EBI-15529529, EBI-15529595; P51865; Q9PW55: xx:tdsubc_2b12; Xeno; NbExp=2; IntAct=EBI-15529529, EBI-42477704; Cell membrane ; Lipid-anchor, GPI-anchor Secreted Note=Released from the cell membrane by GPI cleavage. Expressed at low level in specific organs of the adult animal such as spleen, heart, lung and brain. During gastrulation, expressed in the forming mesoderm. In later stages of the developing heart, expression is restricted to the truncus arteriosus. First expressed prior to the onset of gastrulation (early streak stage), then continues throughout embryonic development. The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (Tmem8a), removing an acyl-chain at the sn-2 position of GPI and releasing CRIPTO as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (Gpld1) into a soluble form. Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. activation of MAPK activity vasculogenesis in utero embryonic development morphogenesis of a branching structure positive regulation of cell-matrix adhesion cell migration involved in sprouting angiogenesis receptor binding protein binding extracellular region extracellular space nucleus cytoplasm Golgi apparatus plasma membrane determination of left/right symmetry gastrulation heart development growth factor activity positive regulation of cell proliferation anterior/posterior axis specification, embryo anterior/posterior axis specification anterior/posterior pattern specification regulation of signal transduction cell surface positive regulation of endothelial cell migration coreceptor activity membrane apical plasma membrane Wnt-protein binding peptidyl-serine phosphorylation extrinsic component of plasma membrane cell differentiation regulation of cell migration positive regulation of cell migration BMP signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway anchored component of membrane cellular response to hepatocyte growth factor stimulus nodal signaling pathway nodal binding negative regulation of apoptotic process cellular response to fibroblast growth factor stimulus membrane raft positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation perinuclear region of cytoplasm anatomical structure development positive regulation of peptidyl-tyrosine phosphorylation cardiac muscle cell differentiation activin receptor binding type I activin receptor binding cellular response to interferon-gamma cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus epidermal growth factor receptor signaling pathway uc009rvg.1 uc009rvg.2 uc009rvg.3 
ENSMUST00000035076.9 Lrrc2 ENSMUST00000035076.9 leucine rich repeat containing 2 (from RefSeq NM_028838.2) A0A0R4J0F2 A0A0R4J0F2_MOUSE ENSMUST00000035076.1 ENSMUST00000035076.2 ENSMUST00000035076.3 ENSMUST00000035076.4 ENSMUST00000035076.5 ENSMUST00000035076.6 ENSMUST00000035076.7 ENSMUST00000035076.8 Lrrc2 NM_028838 uc009rvh.1 uc009rvh.2 uc009rvh.3 uc009rvh.1 uc009rvh.2 uc009rvh.3 
ENSMUST00000035077.8 Ltf ENSMUST00000035077.8 lactotransferrin (from RefSeq NM_008522.3) ENSMUST00000035077.1 ENSMUST00000035077.2 ENSMUST00000035077.3 ENSMUST00000035077.4 ENSMUST00000035077.5 ENSMUST00000035077.6 ENSMUST00000035077.7 NM_008522 P08071 P70690 Q61799 Q8CBA0 Q922P2 TRFL_MOUSE uc009rvj.1 uc009rvj.2 uc009rvj.3 Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity. Antimicrobial properties may include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. May have anabolic, differentiating and anti-apoptotic effects on osteoblasts and may also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. May interfere with the lipopolysaccharide (LPS)-stimulated TLR4 signaling (By similarity). The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. Monomer. Found in a complex with LTF, CLU, EPPIN and SEMG1 (By similarity). Secreted. Cytoplasmic granule Note=Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils (By similarity). Belongs to the transferrin family. ossification lipopolysaccharide binding regulation of cytokine production innate immune response in mucosa immune system process serine-type endopeptidase activity cysteine-type endopeptidase inhibitor activity iron ion binding extracellular region extracellular space cytoplasm proteolysis ion transport heparin binding peptidase activity serine-type peptidase activity cell surface hydrolase activity antibacterial humoral response antifungal humoral response secretory granule killing of cells of other organism negative regulation of lipopolysaccharide-mediated signaling pathway regulation of tumor necrosis factor production negative regulation of ATPase activity macromolecular complex positive regulation of osteoblast proliferation positive regulation of toll-like receptor 4 signaling pathway specific granule negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling protein serine/threonine kinase activator activity other organism cell membrane negative regulation by host of viral process negative regulation of viral genome replication innate immune response positive regulation of osteoblast differentiation negative regulation of membrane potential metal ion binding negative regulation of viral process defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity membrane disruption in other organism iron ion homeostasis bone morphogenesis positive regulation of protein serine/threonine kinase activity positive regulation of bone mineralization involved in bone maturation negative regulation of single-species biofilm formation in or on host organism positive regulation of chondrocyte proliferation negative regulation of cysteine-type endopeptidase activity negative regulation of tumor necrosis factor (ligand) superfamily member 11 production negative regulation of osteoclast development uc009rvj.1 uc009rvj.2 uc009rvj.3 
ENSMUST00000035079.10 Mlh1 ENSMUST00000035079.10 mutL homolog 1, transcript variant 1 (from RefSeq NM_026810.2) ENSMUST00000035079.1 ENSMUST00000035079.2 ENSMUST00000035079.3 ENSMUST00000035079.4 ENSMUST00000035079.5 ENSMUST00000035079.6 ENSMUST00000035079.7 ENSMUST00000035079.8 ENSMUST00000035079.9 MLH1_MOUSE NM_026810 Q3TG77 Q62454 Q9JK91 uc009rvp.1 uc009rvp.2 uc009rvp.3 uc009rvp.4 Heterodimerizes with Pms2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (Mlh1-Pms2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with Mlh3 to form MutL gamma which plays a role in meiosis (By similarity). Component of the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1. Heterodimer of MLH1 and PMS2 (MutL alpha), MLH1 and PMS1 (MutL beta) or MLH1 and MLH3 (MutL gamma). Forms a ternary complex with MutS alpha (MSH2-MSH6) or MutS beta (MSH2- MSH3). Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50- MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with MCM9; the interaction recruits MLH1 to chromatin. Interacts with MCM8. Interacts with PMS2. Interacts with MBD4. Interacts with EXO1. Interacts with MTMR15/FAN1. Nucleus Chromosome Note=Recruited to chromatin in a MCM9-dependent manner. Belongs to the DNA mismatch repair MutL/HexB family. nucleotide binding nuclear-transcribed mRNA poly(A) tail shortening resolution of meiotic recombination intermediates condensed chromosome condensed nuclear chromosome synaptonemal complex male germ cell nucleus somatic recombination of immunoglobulin genes involved in immune response chromatin binding single-stranded DNA binding ATP binding nucleus nucleoplasm chromosome chiasma late recombination nodule DNA repair mismatch repair double-strand break repair via nonhomologous end joining cellular response to DNA damage stimulus cell cycle male meiosis chromosome segregation synapsis reciprocal meiotic recombination male meiosis spermatogenesis intrinsic apoptotic signaling pathway in response to DNA damage response to bacterium female meiosis chromosome segregation somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments ATPase activity enzyme binding mismatched DNA binding guanine/thymine mispair binding mismatch repair complex MutLalpha complex MutSalpha complex binding meiotic metaphase I plate congression meiotic chromosome segregation meiotic telomere clustering homologous chromosome segregation isotype switching negative regulation of mitotic recombination positive regulation of isotype switching to IgA isotypes positive regulation of isotype switching to IgG isotypes oogenesis meiotic spindle midzone assembly meiotic cell cycle uc009rvp.1 uc009rvp.2 uc009rvp.3 uc009rvp.4 
ENSMUST00000035083.8 Stac ENSMUST00000035083.8 src homology three (SH3) and cysteine rich domain, transcript variant 1 (from RefSeq NM_016853.4) ENSMUST00000035083.1 ENSMUST00000035083.2 ENSMUST00000035083.3 ENSMUST00000035083.4 ENSMUST00000035083.5 ENSMUST00000035083.6 ENSMUST00000035083.7 NM_016853 Q3UPL9 Q3UPL9_MOUSE Stac uc009rvw.1 uc009rvw.2 uc009rvw.3 Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side intracellular signal transduction metal ion binding uc009rvw.1 uc009rvw.2 uc009rvw.3 
ENSMUST00000035090.14 Fbxl2 ENSMUST00000035090.14 F-box and leucine-rich repeat protein 2 (from RefSeq NM_178624.7) ENSMUST00000035090.1 ENSMUST00000035090.10 ENSMUST00000035090.11 ENSMUST00000035090.12 ENSMUST00000035090.13 ENSMUST00000035090.2 ENSMUST00000035090.3 ENSMUST00000035090.4 ENSMUST00000035090.5 ENSMUST00000035090.6 ENSMUST00000035090.7 ENSMUST00000035090.8 ENSMUST00000035090.9 FBXL2_MOUSE Fbxl2 NM_178624 Q8BH16 Q8BXM4 uc009rxa.1 uc009rxa.2 uc009rxa.3 Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21343341, PubMed:23542741). Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin- binding motifs and is thereby antagonized by calmodulin (By similarity). This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin (By similarity). Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (By similarity). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (By similarity). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (PubMed:21343341). The SCF(FBXL2) complex acts as a regulator of inflammation by mediating ubiquitination and degradation of TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5 and TRAF6) (PubMed:23542741). The SCF(FBXL2) complex acts as a negative regulator of the NLRP3 inflammasome by mediating ubiquitination and degradation of NLRP3 (By similarity). Protein modification; protein ubiquitination. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL2) composed of CUL1, SKP1, RBX1 and FBXL2. Interacts with calmodulin; may antagonize substrate ubiquitination by SCF(FBXL2). May interact with PIK3R1. Interacts with PTPN13. Membrane ; Lipid- anchor The CAAX motif is a signal for the geranylgeranylation of FBXL2 and is required for its association with cell membranes and the recruitment of substrates to the active SCF(FBXL2) complex. Phosphorylated by GSK-beta (GSK3B), promoting recognition by FBXO3, leading to its ubiquitination by the SCF(FBXO3) complex. Ubiquitinated at Lys-201 by the SCF(FBXO3) complex in response to lipopolysaccharide (LPS), leading to its degradation by the proteasome. May play a role in P. Aeruginosa-induced surfactant deficiency by inhibiting PCYT1A in a calcium-dependent manner. ubiquitin-protein transferase activity protein binding calmodulin binding ubiquitin-dependent protein catabolic process protein monoubiquitination regulation of autophagy regulation of phosphatidylinositol 3-kinase signaling membrane protein ubiquitination SCF ubiquitin ligase complex protein phosphatase binding SCF-dependent proteasomal ubiquitin-dependent protein catabolic process phosphatidylinositol 3-kinase regulatory subunit binding modulation by host of viral RNA genome replication uc009rxa.1 uc009rxa.2 uc009rxa.3 
ENSMUST00000035092.7 Myd88 ENSMUST00000035092.7 myeloid differentiation primary response gene 88 (from RefSeq NM_010851.3) ENSMUST00000035092.1 ENSMUST00000035092.2 ENSMUST00000035092.3 ENSMUST00000035092.4 ENSMUST00000035092.5 ENSMUST00000035092.6 Myd88 NM_010851 Q3U7M4 Q3U7M4_MOUSE uc009sar.1 uc009sar.2 uc009sar.3 Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Cytoplasm immune system process MyD88-dependent toll-like receptor signaling pathway receptor binding Toll binding interleukin-1 receptor binding cytoplasm inflammatory response signal transduction JNK cascade Toll signaling pathway postsynaptic density cytokine-mediated signaling pathway macromolecular complex positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of smooth muscle cell proliferation TIR domain binding uc009sar.1 uc009sar.2 uc009sar.3 
ENSMUST00000035094.14 Exog ENSMUST00000035094.14 exo/endonuclease G, transcript variant 2 (from RefSeq NM_172456.4) ENSMUST00000035094.1 ENSMUST00000035094.10 ENSMUST00000035094.11 ENSMUST00000035094.12 ENSMUST00000035094.13 ENSMUST00000035094.2 ENSMUST00000035094.3 ENSMUST00000035094.4 ENSMUST00000035094.5 ENSMUST00000035094.6 ENSMUST00000035094.7 ENSMUST00000035094.8 ENSMUST00000035094.9 EXOG_MOUSE Endogl1 NM_172456 Q3UFL2 Q8C163 uc009saz.1 uc009saz.2 uc009saz.3 uc009saz.4 Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity. Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Homodimer. Mitochondrion inner membrane The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules. Belongs to the DNA/RNA non-specific endonuclease family. single-stranded DNA endodeoxyribonuclease activity DNA catabolic process, endonucleolytic nucleic acid binding nuclease activity endonuclease activity endoribonuclease activity nucleus mitochondrion mitochondrial inner membrane apoptotic DNA fragmentation 5'-3' exonuclease activity membrane hydrolase activity macromolecular complex metal ion binding RNA phosphodiester bond hydrolysis, endonucleolytic uc009saz.1 uc009saz.2 uc009saz.3 uc009saz.4 
ENSMUST00000035099.9 Gorasp1 ENSMUST00000035099.9 golgi reassembly stacking protein 1 (from RefSeq NM_028976.2) ENSMUST00000035099.1 ENSMUST00000035099.2 ENSMUST00000035099.3 ENSMUST00000035099.4 ENSMUST00000035099.5 ENSMUST00000035099.6 ENSMUST00000035099.7 ENSMUST00000035099.8 GORS1_MOUSE NM_028976 Q91X51 Q9D3L9 uc009sbq.1 uc009sbq.2 uc009sbq.3 Key structural protein of the Golgi apparatus (PubMed:32573693). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:32573693). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:32573693). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (By similarity). Homodimer. Forms higher-order oligomers under interphase but not mitotic conditions. Dimers of the protein on one membrane might be able to interact with dimers on another and so stack cisternae. Interacts with the C-terminus of GOLGA2/GM130 under both mitotic and non-mitotic conditions. The interaction is critical for the correct targeting of both proteins to the cis-Golgi. Interacts with TMED2 and TMED3. Golgi apparatus, cis-Golgi network membrane ; Peripheral membrane protein ; Cytoplasmic side Phosphorylated by CDC2/B1 and PLK kinases during mitosis. Phosphorylation cycle correlates with the cisternal stacking cycle. Phosphorylation of the homodimer prevents the association of dimers into higher-order oligomers, leading to cisternal unstacking. Target for caspase-3 cleavage during apoptosis. The cleavage contributes to Golgi fragmentation and occurs very early in the execution phase of apoptosis. Myristoylated. No visible loss of Golgi stacking in intestinal tissue at postnatal day 10, 21 or 42, in combination with conditional knockout of GORASP2/GRASP55 (PubMed:32573693). However, cisternal cross-sectional diameters are reduced and rims of the Golgi cisternae are vacuolated (PubMed:32573693). Abolishes expression of GOLGA2/GM130 in the cisternae (PubMed:32573693). Belongs to the GORASP family. Sequence=BAB30676.1; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm Golgi apparatus protein N-linked glycosylation Golgi organization protein transport membrane metal ion binding negative regulation of dendrite morphogenesis uc009sbq.1 uc009sbq.2 uc009sbq.3 
ENSMUST00000035100.6 Ttc21a ENSMUST00000035100.6 tetratricopeptide repeat domain 21A (from RefSeq NM_028735.3) ENSMUST00000035100.1 ENSMUST00000035100.2 ENSMUST00000035100.3 ENSMUST00000035100.4 ENSMUST00000035100.5 NM_028735 Q0HA37 Q3V0A2 Q8C0S4 Q9D5Q9 TT21A_MOUSE Thm2 uc009sbt.1 uc009sbt.2 Intraflagellar transport (IFT)-associated protein required for spermatogenesis (PubMed:30929735). Required for sperm flagellar formation and intraflagellar transport (PubMed:30929735). Interacts with IFT20. Interacts with IFT52. Interacts with IFT140. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C0S4-1; Sequence=Displayed; Name=2; IsoId=Q8C0S4-2; Sequence=VSP_026304, VSP_026305; Male mice display strongly reduced fertility (PubMed:30929735). Spermatozoa show significantly reduced motility and morphologic abnormalities are observed, such as primarily tailless spermatozoa with an abnormal head-tail junction, as well as short and coiled flagella (PubMed:30929735). Structural abnormalities of the connecting piece are observed during spermiogenesis and multiple structural defects of the flagella, with a greatly increased percentage of flagella exhibiting abnormal principal pieces and end pieces (PubMed:30929735). Axonemal structural abnormalities, such as abnormal bulges, extra peripheral microtubule doublets, lack of central-pair microtubules, absent dynein arms, and abnormal arrangement of the 9 peripheral microtubule doubles, are also frequently observed (PubMed:30929735). Belongs to the TTC21 family. molecular_function cilium intraciliary transport particle A intraciliary retrograde transport protein localization to cilium uc009sbt.1 uc009sbt.2 
ENSMUST00000035101.9 Csrnp1 ENSMUST00000035101.9 cysteine-serine-rich nuclear protein 1, transcript variant 3 (from RefSeq NM_001357561.1) Axud1 CSRN1_MOUSE ENSMUST00000035101.1 ENSMUST00000035101.2 ENSMUST00000035101.3 ENSMUST00000035101.4 ENSMUST00000035101.5 ENSMUST00000035101.6 ENSMUST00000035101.7 ENSMUST00000035101.8 NM_001357561 P59054 Q3USP7 Taip3 uc292mea.1 uc292mea.2 Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. May have a tumor-suppressor function. May play a role in apoptosis. Nucleus Widely expressed with highest levels in thymus and lung. Low levels detected in naive T-cells. By interleukin-2. Mice display no obvious defects in development, hematopoiesis or T-cell function. Deletion of Csrnp1, Csrnp2 and Csrnp3 together causes partial neonatal lethality, suggesting that they have redundant functions. Belongs to the AXUD1 family. transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated apoptotic process post-embryonic development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter platelet-derived growth factor receptor signaling pathway skeletal system morphogenesis palate development face morphogenesis uc292mea.1 uc292mea.2 
ENSMUST00000035105.7 Rpsa ENSMUST00000035105.7 ribosomal protein SA (from RefSeq NM_011029.4) ENSMUST00000035105.1 ENSMUST00000035105.2 ENSMUST00000035105.3 ENSMUST00000035105.4 ENSMUST00000035105.5 ENSMUST00000035105.6 Lamr1 NM_011029 P14206 P40-8 Q58E74 Q8BHL0 Q8BNL2 Q91V31 Q9CY13 RSSA_MOUSE uc009scd.1 uc009scd.2 uc009scd.3 uc009scd.4 Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). Enables malignant tumor cells to penetrate laminin tissue and vessel barriers. Activates precursor thymic anti- OFA/iLRP specific cytotoxic T-cell. May induce CD8 T-suppressor cells secreting IL-10. Monomer (37LRP) and homodimer (67LR) (By similarity). Component of the small ribosomal subunit (PubMed:36517592). Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S) (PubMed:36517592). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:36517592). Interacts with RPS21 (By similarity). Interacts with several laminins including at least LAMB1. Interacts with MDK. Interacts with PRNP. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B (By similarity). Cell membrane. Cytoplasm Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Colocalizes with PPP1R16B in the cell membrane (By similarity). 37LRP shuttles to the nucleus upon midkine (MDK) binding. Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association. Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions. This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity. Belongs to the universal ribosomal protein uS2 family. ribosomal small subunit assembly cytoplasmic translation structural constituent of ribosome laminin receptor activity basement membrane nucleus cytoplasm cytosol ribosome plasma membrane translation cell adhesion small ribosomal subunit membrane cytosolic small ribosomal subunit epithelial cell differentiation ribosome binding neuronal cell body laminin binding synapse cell-cell adhesion glutamatergic synapse uc009scd.1 uc009scd.2 uc009scd.3 uc009scd.4 
ENSMUST00000035106.12 Slc25a38 ENSMUST00000035106.12 solute carrier family 25, member 38, transcript variant 1 (from RefSeq NM_144793.2) ENSMUST00000035106.1 ENSMUST00000035106.10 ENSMUST00000035106.11 ENSMUST00000035106.2 ENSMUST00000035106.3 ENSMUST00000035106.4 ENSMUST00000035106.5 ENSMUST00000035106.6 ENSMUST00000035106.7 ENSMUST00000035106.8 ENSMUST00000035106.9 NM_144793 Q91XD8 S2538_MOUSE Slc25a38 uc009scc.1 uc009scc.2 uc009scc.3 uc009scc.4 Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. Plays a role as pro-apoptotic protein that induces caspase- dependent apoptosis. Reaction=glycine(in) = glycine(out); Xref=Rhea:RHEA:70715, ChEBI:CHEBI:57305; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. mitochondrion mitochondrial inner membrane glycine transmembrane transporter activity membrane integral component of membrane erythrocyte differentiation transmembrane glycine transport from cytosol to mitochondrion uc009scc.1 uc009scc.2 uc009scc.3 uc009scc.4 
ENSMUST00000035110.11 Hhatl ENSMUST00000035110.11 hedgehog acyltransferase-like, transcript variant 1 (from RefSeq NM_029095.2) ENSMUST00000035110.1 ENSMUST00000035110.10 ENSMUST00000035110.2 ENSMUST00000035110.3 ENSMUST00000035110.4 ENSMUST00000035110.5 ENSMUST00000035110.6 ENSMUST00000035110.7 ENSMUST00000035110.8 ENSMUST00000035110.9 Gup1 HHATL_MOUSE Kiaa1173 NM_029095 Q3TZE3 Q8R1K3 Q9D1G3 uc009sdx.1 uc009sdx.2 uc009sdx.3 Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN. Interacts with SHH. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the membrane-bound acyltransferase family. HHAT subfamily. protein binding endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane transferase activity, transferring acyl groups perinuclear region of cytoplasm negative regulation of N-terminal protein palmitoylation uc009sdx.1 uc009sdx.2 uc009sdx.3 
ENSMUST00000035112.13 Nktr ENSMUST00000035112.13 natural killer tumor recognition sequence (from RefSeq NM_010918.3) ENSMUST00000035112.1 ENSMUST00000035112.10 ENSMUST00000035112.11 ENSMUST00000035112.12 ENSMUST00000035112.2 ENSMUST00000035112.3 ENSMUST00000035112.4 ENSMUST00000035112.5 ENSMUST00000035112.6 ENSMUST00000035112.7 ENSMUST00000035112.8 ENSMUST00000035112.9 F8VPR8 NKTR_MOUSE NM_010918 Nktr P30415 Q3UNH0 uc009sdr.1 uc009sdr.2 uc009sdr.3 PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumor-recognition complex involved in the function of NK cells. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Inhibited by cyclosporin A (CsA). Cell membrane Sequence=AAA37500.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity nucleoplasm mitochondrion cytosol plasma membrane protein folding cyclosporin A binding membrane isomerase activity protein refolding unfolded protein binding uc009sdr.1 uc009sdr.2 uc009sdr.3 
ENSMUST00000035113.11 Ss18l2 ENSMUST00000035113.11 SS18, nBAF chromatin remodeling complex subunit like 2 (from RefSeq NM_026794.2) Deb1 ENSMUST00000035113.1 ENSMUST00000035113.10 ENSMUST00000035113.2 ENSMUST00000035113.3 ENSMUST00000035113.4 ENSMUST00000035113.5 ENSMUST00000035113.6 ENSMUST00000035113.7 ENSMUST00000035113.8 ENSMUST00000035113.9 NM_026794 Q9D174 S18L2_MOUSE uc009sdo.1 uc009sdo.2 uc009sdo.3 Belongs to the SS18 family. molecular_function transcription coactivator activity nucleus positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of dendrite morphogenesis uc009sdo.1 uc009sdo.2 uc009sdo.3 
ENSMUST00000035115.5 Vipr1 ENSMUST00000035115.5 vasoactive intestinal peptide receptor 1 (from RefSeq NM_011703.4) ENSMUST00000035115.1 ENSMUST00000035115.2 ENSMUST00000035115.3 ENSMUST00000035115.4 NM_011703 P97751 Q9JI40 Q9R1T8 VIPR1_MOUSE uc009sdl.1 uc009sdl.2 uc009sdl.3 This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 2 family. transmembrane signaling receptor activity G-protein coupled receptor activity vasoactive intestinal polypeptide receptor activity plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger G-protein coupled peptide receptor activity membrane integral component of membrane peptide hormone binding receptor complex uc009sdl.1 uc009sdl.2 uc009sdl.3 
ENSMUST00000035116.12 Pccb ENSMUST00000035116.12 propionyl Coenzyme A carboxylase, beta polypeptide, transcript variant 1 (from RefSeq NM_025835.3) ENSMUST00000035116.1 ENSMUST00000035116.10 ENSMUST00000035116.11 ENSMUST00000035116.2 ENSMUST00000035116.3 ENSMUST00000035116.4 ENSMUST00000035116.5 ENSMUST00000035116.6 ENSMUST00000035116.7 ENSMUST00000035116.8 ENSMUST00000035116.9 NM_025835 PCCB_MOUSE Pccb Q99MN9 Q9DBG2 uc009rfc.1 uc009rfc.2 uc009rfc.3 uc009rfc.4 This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl- CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)- ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). Reaction=ATP + hydrogencarbonate + propanoyl-CoA = (S)-methylmalonyl- CoA + ADP + H(+) + phosphate; Xref=Rhea:RHEA:23720, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57327, ChEBI:CHEBI:57392, ChEBI:CHEBI:456216; EC=6.4.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23721; Evidence=; Reaction=ATP + butanoyl-CoA + hydrogencarbonate = (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate; Xref=Rhea:RHEA:59520, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57371, ChEBI:CHEBI:60909, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59521; Evidence=; Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3. The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits. Mitochondrion matrix Broadly expressed. Most abundantly expressed in the kidney, liver, small intestine and stomach. The beta subunit contains the carboxyl transferase (CT) domain. Belongs to the AccD/PCCB family. nucleotide binding propionyl-CoA carboxylase activity ATP binding mitochondrion mitochondrial matrix ligase activity uc009rfc.1 uc009rfc.2 uc009rfc.3 uc009rfc.4 
ENSMUST00000035120.6 Cck ENSMUST00000035120.6 cholecystokinin, transcript variant 1 (from RefSeq NM_031161.5) CCKN_MOUSE ENSMUST00000035120.1 ENSMUST00000035120.2 ENSMUST00000035120.3 ENSMUST00000035120.4 ENSMUST00000035120.5 NM_031161 P09240 Q53WS9 Q9DCL5 uc009sdg.1 uc009sdg.2 uc009sdg.3 uc009sdg.4 This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Homozygous knockout mice for this gene exhibit impaired insulin secretion, enhanced insulin sensitivity, and resistance to obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]. This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain. Secreted Expressed and secreted by discrete enteroendocrine cells that reside as single cells scattered among enterocytes in the mucosa of the small intestine. Released into the blood following ingestion of a meal. The precursor is cleaved by proteases to produce a number of active cholecystokinins. Belongs to the gastrin/cholecystokinin family. neuron migration release of cytochrome c from mitochondria hormone activity neuropeptide hormone activity protein binding extracellular region extracellular space apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase C-activating G-protein coupled receptor signaling pathway axonogenesis digestion memory positive regulation of cell proliferation visual learning positive regulation of glutamate secretion axon dendrite negative regulation of appetite positive regulation of protein oligomerization eating behavior neuronal cell body positive regulation of apoptotic process axon initial segment terminal bouton axon hillock perikaryon positive regulation of peptidyl-tyrosine phosphorylation peptide hormone receptor binding positive regulation of mitochondrial depolarization regulation of sensory perception of pain negative regulation of eating behavior positive regulation of sensory perception of pain negative regulation of behavioral fear response positive regulation of behavioral fear response uc009sdg.1 uc009sdg.2 uc009sdg.3 uc009sdg.4 
ENSMUST00000035121.14 Amotl2 ENSMUST00000035121.14 angiomotin-like 2, transcript variant 1 (from RefSeq NM_019764.2) AMOL2_MOUSE B8JK80 ENSMUST00000035121.1 ENSMUST00000035121.10 ENSMUST00000035121.11 ENSMUST00000035121.12 ENSMUST00000035121.13 ENSMUST00000035121.2 ENSMUST00000035121.3 ENSMUST00000035121.4 ENSMUST00000035121.5 ENSMUST00000035121.6 ENSMUST00000035121.7 ENSMUST00000035121.8 ENSMUST00000035121.9 NM_019764 Q3TPM1 Q7TPE4 Q8BP84 Q8BS08 Q8K371 Q9QUS0 uc009rfx.1 uc009rfx.2 uc009rfx.3 Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity). Interacts with SRC. Recycling endosome Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway. Belongs to the angiomotin family. Sequence=BAC30740.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC36853.1; Type=Frameshift; Evidence=; angiogenesis establishment of cell polarity involved in ameboidal cell migration protein binding endosome bicellular tight junction Wnt signaling pathway apical plasma membrane actin cytoskeleton organization regulation of cell migration cytoplasmic vesicle hippo signaling identical protein binding recycling endosome uc009rfx.1 uc009rfx.2 uc009rfx.3 
ENSMUST00000035129.14 Ephb1 ENSMUST00000035129.14 Eph receptor B1, transcript variant 1 (from RefSeq NM_173447.3) B1B1C2 ENSMUST00000035129.1 ENSMUST00000035129.10 ENSMUST00000035129.11 ENSMUST00000035129.12 ENSMUST00000035129.13 ENSMUST00000035129.2 ENSMUST00000035129.3 ENSMUST00000035129.4 ENSMUST00000035129.5 ENSMUST00000035129.6 ENSMUST00000035129.7 ENSMUST00000035129.8 ENSMUST00000035129.9 EPHB1_MOUSE NM_173447 Q3UY27 Q6PG23 Q8CBE2 Q8CBF3 uc009rfn.1 uc009rfn.2 uc009rfn.3 Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (PubMed:27446912). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts with EPHB6; transphosphorylates EPHB6 to form an active signaling complex (By similarity). Interacts with PICK1. Interacts (through Tyr-594) with NCK1 (via SH2 domain); activates the JUN cascade to regulate cell adhesion. The ligand-activated form interacts (through Tyr-928) with GRB7 and GRB10 (via SH2 domains). The ligand-activated form interacts (residues within the catalytic domain) with GRB2 (via SH2 domain). Interacts with GRB2, SHC1 and SRC; activates the MAPK/ERK cascade to regulate cell migration. Interacts with CBL; regulates receptor degradation through ubiquitination. Interacts with ACP1. Cell membrane ; Single-pass type I membrane protein Early endosome membrane Cell projection, dendrite Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CBF3-1; Sequence=Displayed; Name=2; IsoId=Q8CBF3-2; Sequence=VSP_021595; Expressed in neural stem and progenitor cells in the dentate gyrus (PubMed:18057206). Expressed in myogenic progenitor cells (PubMed:27446912). Expressed in growth cones of ventrotemporal (uncrossed) retinal ganglion cells that give rise to ipsilateral projections (at protein level) (PubMed:12971893, PubMed:18524895). In myogenic progenitor cells, initially expressed early during myogenic development (11.5 dpc), down-regulated during the fetal stage (lower levels at 17.5 dpc) to be re-expressed in postnatal satellite cells (PubMed:27446912). Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL (By similarity). Ubiquitinated; (EFNB1)ligand-induced poly- and/or multi- ubiquitination by CBL is regulated by SRC and leads to lysosomal degradation. Mice development is apparently normal. However, they display a dramatic reduction of ipsilateral retinal projection. Mice do not develop neuropathic algesia and physical dependence to morphine. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. nucleotide binding angiogenesis immunological synapse formation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity transmembrane-ephrin receptor activity protein binding ATP binding cytoplasm endosome endoplasmic reticulum cytosol plasma membrane integral component of plasma membrane protein phosphorylation cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway nervous system development axon guidance axon guidance receptor activity skeletal muscle satellite cell activation membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation cranial nerve development optic nerve morphogenesis central nervous system projection neuron axonogenesis neurogenesis establishment of cell polarity axon dendrite retinal ganglion cell axon guidance cell-substrate adhesion early endosome membrane filopodium tip cell projection receptor complex macromolecular complex binding membrane raft regulation of JNK cascade protein autophosphorylation ephrin receptor signaling pathway camera-type eye morphogenesis modulation of synaptic transmission detection of temperature stimulus involved in sensory perception of pain positive regulation of synapse assembly cell chemotaxis dendritic spine development dendritic spine morphogenesis neural precursor cell proliferation regulation of ERK1 and ERK2 cascade glutamatergic synapse regulation of neuron death negative regulation of skeletal muscle satellite cell proliferation negative regulation of satellite cell differentiation uc009rfn.1 uc009rfn.2 uc009rfn.3 
ENSMUST00000035148.13 Slco2a1 ENSMUST00000035148.13 solute carrier organic anion transporter family, member 2a1, transcript variant 1 (from RefSeq NM_033314.4) ENSMUST00000035148.1 ENSMUST00000035148.10 ENSMUST00000035148.11 ENSMUST00000035148.12 ENSMUST00000035148.2 ENSMUST00000035148.3 ENSMUST00000035148.4 ENSMUST00000035148.5 ENSMUST00000035148.6 ENSMUST00000035148.7 ENSMUST00000035148.8 ENSMUST00000035148.9 NM_033314 Oatp2a1 Q9EPT5 SO2A1_MOUSE Slc21a2 Slco2a1 uc009rgd.1 uc009rgd.2 uc009rgd.3 Mediates the transport of prostaglandins (PGs, mainly PGE2, PGE1, PGE3, PGF2alpha, PGD2, PGH2) and thromboxanes (thromboxane B2) across the cell membrane (PubMed:10484490) (Probable). PGs and thromboxanes play fundamental roles in diverse functions such as intraocular pressure, gastric acid secretion, renal salt and water transport, vascular tone, and fever (By similarity). Plays a role in the clearance of PGs from the circulation through cellular uptake, which allows cytoplasmic oxidation and PG signal termination (PubMed:10484490) (Probable). PG uptake is dependent upon membrane potential and involves exchange of a monovalent anionic substrate (PGs exist physiologically as an anionic monovalent form) with a stoichiometry of 1:1 for divalent anions or of 1:2 for monovalent anions (By similarity). Uses lactate, generated by glycolysis, as a counter-substrate to mediate PG influx and efflux. Under nonglycolytic conditions, metabolites other than lactate might serve as counter- substrates. Although the mechanism is not clear, this transporter can function in bidirectional mode (By similarity). When apically expressed in epithelial cells, it facilitates transcellular transport (also called vectorial release), extracting PG from the apical medium and facilitating transport across the cell toward the basolateral side, whereupon the PG exits the cell by simple diffusion (PubMed:18579702). In the renal collecting duct, regulates renal Na+ balance by removing PGE2 from apical medium (PGE2 EP4 receptor is likely localized to the luminal/apical membrane and stimulates Na+ resorption) and transporting it toward the basolateral membrane (where PGE2 EP1 and EP3 receptors inhibit Na+ resorption) (PubMed:18579702). Plays a role in endometrium during decidualization, increasing uptake of PGs by decidual cells (By similarity). Involved in critical events for ovulation (PubMed:27169804). Regulates extracellular PGE2 concentration for follicular development in the ovaries (PubMed:27169804). When expressed intracellularly, such as in macrophages, contributes to vesicular uptake of newly synthesized intracellular PGs, thereby facilitating exocytotic secretion of PGs without being metabolized (PubMed:26474801). Essential core component of the major type of large- conductance anion channel, Maxi-Cl, which plays essential roles in inorganic anion transport, cell volume regulation and release of ATP and glutamate not only in physiological processes but also in pathological processes (PubMed:29046334, PubMed:32442363). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). Reaction=prostaglandin E2(out) = prostaglandin E2(in); Xref=Rhea:RHEA:50984, ChEBI:CHEBI:606564; Evidence=; Reaction=2 (S)-lactate(in) + prostaglandin E2(out) = 2 (S)-lactate(out) + prostaglandin E2(in); Xref=Rhea:RHEA:74383, ChEBI:CHEBI:16651, ChEBI:CHEBI:606564; Evidence= Reaction=2 (S)-lactate(in) + prostaglandin E1(out) = 2 (S)-lactate(out) + prostaglandin E1(in); Xref=Rhea:RHEA:74395, ChEBI:CHEBI:16651, ChEBI:CHEBI:57397; Evidence=; Reaction=2 (S)-lactate(in) + prostaglandin F2alpha(out) = 2 (S)- lactate(out) + prostaglandin F2alpha(in); Xref=Rhea:RHEA:74399, ChEBI:CHEBI:16651, ChEBI:CHEBI:57404; Evidence=; Reaction=2 (S)-lactate(in) + prostaglandin D2(out) = 2 (S)-lactate(out) + prostaglandin D2(in); Xref=Rhea:RHEA:74403, ChEBI:CHEBI:16651, ChEBI:CHEBI:57406; Evidence=; Reaction=2 (S)-lactate(in) + thromboxane B2(out) = 2 (S)-lactate(out) + thromboxane B2(in); Xref=Rhea:RHEA:74407, ChEBI:CHEBI:16651, ChEBI:CHEBI:90696; Evidence=; Reaction=2 (S)-lactate(in) + prostaglandin E3(out) = 2 (S)-lactate(out) + prostaglandin E3(in); Xref=Rhea:RHEA:74351, ChEBI:CHEBI:16651, ChEBI:CHEBI:133132; Evidence=; Reaction=2 (S)-lactate(in) + prostaglandin H2(out) = 2 (S)-lactate(out) + prostaglandin H2(in); Xref=Rhea:RHEA:74379, ChEBI:CHEBI:16651, ChEBI:CHEBI:57405; Evidence=; Higher dietary salt intake stimulates transcription (PubMed:18579702). Chorionic gonadotropin stimulates expression in the ovaries (PubMed:27169804). Cell membrane ; Multi-pass membrane protein Basal cell membrane ; Multi-pass membrane protein Cytoplasm Lysosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EPT5-1; Sequence=Displayed; Name=2; IsoId=Q9EPT5-2; Sequence=VSP_006128, VSP_006129; Highly expressed in lung and liver (PubMed:10484490). Expressed at lower levels in kidney and skeletal muscle (PubMed:10484490, PubMed:18579702). Expressed in the ovaries (at mRNA and protein levels) (PubMed:27169804). Expressed in peritoneal macrophages (at mRNA and protein levels) (PubMed:26474801). Belongs to the organo anion transporter (TC 2.A.60) family. plasma membrane integral component of plasma membrane prostaglandin transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity prostaglandin transport membrane integral component of membrane sodium-independent organic anion transport transmembrane transport uc009rgd.1 uc009rgd.2 uc009rgd.3 
ENSMUST00000035154.4 1110059G10Rik ENSMUST00000035154.4 RIKEN cDNA 1110059G10 gene (from RefSeq NM_025419.4) ENSMUST00000035154.1 ENSMUST00000035154.2 ENSMUST00000035154.3 K1143_MOUSE NM_025419 Q8K039 Q9CSR4 Q9D0W8 uc009sfj.1 uc009sfj.2 uc009sfj.3 molecular_function cellular_component biological_process uc009sfj.1 uc009sfj.2 uc009sfj.3 
ENSMUST00000035155.8 Rab6b ENSMUST00000035155.8 RAB6B, member RAS oncogene family (from RefSeq NM_173781.4) ENSMUST00000035155.1 ENSMUST00000035155.2 ENSMUST00000035155.3 ENSMUST00000035155.4 ENSMUST00000035155.5 ENSMUST00000035155.6 ENSMUST00000035155.7 NM_173781 Q0PD53 Q0PD53_MOUSE Rab6B Rab6b uc009rgf.1 uc009rgf.2 uc009rgf.3 GTPase activity GTP binding Golgi apparatus myosin V binding presynapse uc009rgf.1 uc009rgf.2 uc009rgf.3 
ENSMUST00000035157.10 Srprb ENSMUST00000035157.10 signal recognition particle receptor, B subunit (from RefSeq NM_009275.4) ENSMUST00000035157.1 ENSMUST00000035157.2 ENSMUST00000035157.3 ENSMUST00000035157.4 ENSMUST00000035157.5 ENSMUST00000035157.6 ENSMUST00000035157.7 ENSMUST00000035157.8 ENSMUST00000035157.9 NM_009275 P47758 Q544X9 Q9D872 SRPRB_MOUSE uc009rgg.1 uc009rgg.2 uc009rgg.3 Component of the SRP (signal recognition particle) receptor (PubMed:7844142). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:7844142). May mediate the membrane association of SR (PubMed:7844142). Heterodimer with SRPRA. Endoplasmic reticulum membrane ; Single-pass membrane protein Belongs to the SRP receptor beta subunit family. nucleotide binding GTP binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytoplasmic microtubule membrane integral component of membrane ubiquitin protein ligase binding uc009rgg.1 uc009rgg.2 uc009rgg.3 
ENSMUST00000035163.10 Inhca ENSMUST00000035163.10 inhibitor of carbonic anhydrase (from RefSeq NM_027918.2) ENSMUST00000035163.1 ENSMUST00000035163.2 ENSMUST00000035163.3 ENSMUST00000035163.4 ENSMUST00000035163.5 ENSMUST00000035163.6 ENSMUST00000035163.7 ENSMUST00000035163.8 ENSMUST00000035163.9 ICA_MOUSE Ica Inhca NM_027918 Q9DBD0 uc009rgk.1 uc009rgk.2 uc009rgk.3 Inhibitor for carbonic anhydrase 2 (CA2) (By similarity). Does not bind iron ions (PubMed:17511619, PubMed:18712936). Monomer (PubMed:20572014). Interacts (via transferrin-like domain 2) with CA2 (PubMed:18712936). Secreted Detected in blood plasma, heart, kidney, liver, colon, lung, spleen, pancreas and testis (at protein level). N-glycosylated. Belongs to the transferrin family. enzyme inhibitor activity cellular_component extracellular region extracellular space negative regulation of catalytic activity iron ion binding uc009rgk.1 uc009rgk.2 uc009rgk.3 
ENSMUST00000035164.10 Topbp1 ENSMUST00000035164.10 topoisomerase (DNA) II binding protein 1 (from RefSeq NM_176979.5) ENSMUST00000035164.1 ENSMUST00000035164.2 ENSMUST00000035164.3 ENSMUST00000035164.4 ENSMUST00000035164.5 ENSMUST00000035164.6 ENSMUST00000035164.7 ENSMUST00000035164.8 ENSMUST00000035164.9 Kiaa0259 NM_176979 Q6P6P0 Q6ZQF0 Q80Y33 Q8BUI0 Q8BUK1 Q8R348 Q91VX3 Q922X8 TOPB1_MOUSE Topbp1 uc009rgl.1 uc009rgl.2 uc009rgl.3 uc009rgl.4 Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair. Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:14718568). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (By similarity). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (By similarity). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (By similarity). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (By similarity). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (By similarity). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (By similarity). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (By similarity). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (By similarity). Acts as an activator of the kinase activity of ATR (By similarity). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (By similarity). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (By similarity). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (By similarity). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (By similarity). Interacts (via BRCT domains 1 and 2) with (phosphorylated) MDC1; promoting TOPBP1 recruitment to DNA damage sites during mitosis. Interacts (via BRCT domains 7 and 8) with (autophosphorylated) ATR; promoting activation of ATR. Interacts (via BRCT domains 7 and 8) with (phosphorylated) POLQ; specifically binds POLQ phosphorylated by PLK1, promoting POLQ recruitment to DNA damage sites. Interacts (via BRCT domains 1 and 2) with (phosphorylated) RAD9A. Interacts (via BRCT domain 2) with (phosphorylated) TP53BP1. Interacts (via BRCT domain 2) with (phosphorylated) HTATSF1. Interacts (via BRCT domains 7 and 8) with (phosphorylated) RAD51; promoting RAD51 recruitment to damaged chromatin. Interacts with CIP2A; forming the CIP2A-TOPBP1 complex. Interacts with POLE. Interacts with UBR5. Interacts with E2F1. Interacts with PML. Interacts with SMARCA2. Interacts with SMARCA4. Interacts with RHNO1. May interact with TOP2B. Interacts with TICRR. Interacts with HELB. Nucleus Chromosome toplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Note=Localizes to sites of DNA damage, such as double-stranded breaks (DSBs) (By similarity). Recruited to DNA double-strand break (DSBs) during S-phase following interaction with phosphorylated HTATSF1 (By similarity). Recruited to DSBs during mitosis following interaction with phosphorylated MDC1 (By similarity). Has a uniform nuclear distribution during G phase (By similarity). Colocalizes with BRCA1 at stalled replication forks during S phase (By similarity). In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase (By similarity). Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation (By similarity). Detected on unpaired autosomes in meiotic prophase cells (PubMed:14718568, PubMed:22549958). Detected on X and Y chromosomes during later stages of prophase (PubMed:14718568, PubMed:22549958). Colocalizes with ATR and H2AX at unsynapsed chromosome cores during prophase (PubMed:14718568, PubMed:22549958). Localizes to broken chromosomes within micronuclei during interphase and following chromothripsis. Localization to broken chromosomes is mainly independent of MDC1 (By similarity). Highly expressed in testis. Levels increase during the first 3 weeks after birth and remain high in the fourth week. Some BRCT domains specifically recognize and bind phosphoserine/phosphothreonine marks on proteins. BRCT domains 1 and 2 bind phosphorylated MDC1 and RAD9A. BRCT domain 2 binds phosphorylated HTATSF1 and TP53BP1. BRCT domains 7 and 8 bind phosphorylated ATR, POLQ and RAD51. Phosphorylated on serine and threonine residues in response to X- ray irradiation. Ubiquitinated and degraded by the proteasome. X-ray irradiation reduces ubiquitination. Deubiquitinated by USP13; leading to TOPBP1 stabilizion and activation of the ATR-TOPBP1 axis pathway. Belongs to the TOPBP1 family. Sequence=AAH07170.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC39345.1; Type=Frameshift; Evidence=; Sequence=BAC97914.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; condensed nuclear chromosome spindle pole male germ cell nucleus DNA binding nucleus chromosome cytoplasm microtubule organizing center cytoskeleton DNA repair cellular response to DNA damage stimulus reciprocal meiotic recombination response to ionizing radiation actin cytoskeleton nuclear body PML body mitotic DNA replication checkpoint identical protein binding uc009rgl.1 uc009rgl.2 uc009rgl.3 uc009rgl.4 
ENSMUST00000035166.12 Uba5 ENSMUST00000035166.12 ubiquitin-like modifier activating enzyme 5 (from RefSeq NM_025692.3) ENSMUST00000035166.1 ENSMUST00000035166.10 ENSMUST00000035166.11 ENSMUST00000035166.2 ENSMUST00000035166.3 ENSMUST00000035166.4 ENSMUST00000035166.5 ENSMUST00000035166.6 ENSMUST00000035166.7 ENSMUST00000035166.8 ENSMUST00000035166.9 NM_025692 Q3TG27 Q3U8X9 Q3U9E7 Q8VE47 Q9CYD6 UBA5_MOUSE Uba5 uc009rhf.1 uc009rhf.2 uc009rhf.3 uc009rhf.4 E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:21304510). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1- E1 thioester and free AMP (By similarity). Activates UFM1 via a trans- binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (By similarity). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (By similarity). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (By similarity). Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (By similarity). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (PubMed:21304510). Homodimer; homodimerization is required for UFM1 activation (By similarity). Interacts (via UIS motif) with UFM1; binds UFM1 via a trans-binding mechanism in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:21304510). Interacts (via UIS motif) with GABARAPL2 and, with lower affinity, with GABARAP and GABARAPL1 (By similarity). Interacts (via C-terminus) with UFC1 (By similarity). Cytoplasm Nucleus Endoplasmic reticulum membrane Golgi apparatus Note=Localizes mainly in the cytoplasm, while it localizes to the nucleus in presence of SUMO2. Interaction with GABARAPL2 promotes localization to the endoplasmic reticulum membrane. The UFM1-interacting sequence (UIS) motif mediates interaction with both UFM1 and LC3/GABARAP proteins (GABARAP, GABARAPL1 and GABARAPL2). Death at embryonic day 12.5 (PubMed:20018847, PubMed:21304510). Embryonic lethality is caused by severe anemia associated with defective differentiation of both megakaryocytes and erythrocytes from common myeloid progenitors (PubMed:21304510). Belongs to the ubiquitin-activating E1 family. UBA5 subfamily. Was initially reported to mediate activation of SUMO2 in addition to UFM1 (By similarity). However, it was later shown that it is specific for UFM1 (PubMed:21304510). nucleotide binding ATP binding nucleus cytoplasm Golgi apparatus cytosol small protein activating enzyme activity protein modification by small protein conjugation regulation of intracellular estrogen receptor signaling pathway response to endoplasmic reticulum stress intracellular membrane-bounded organelle metal ion binding neuromuscular process UFM1 activating enzyme activity protein ufmylation protein K69-linked ufmylation uc009rhf.1 uc009rhf.2 uc009rhf.3 uc009rhf.4 
ENSMUST00000035167.15 Nphp3 ENSMUST00000035167.15 nephronophthisis 3 (adolescent), transcript variant 1 (from RefSeq NM_028721.3) D6RHB4 E9Q5X1 E9QN29 ENSMUST00000035167.1 ENSMUST00000035167.10 ENSMUST00000035167.11 ENSMUST00000035167.12 ENSMUST00000035167.13 ENSMUST00000035167.14 ENSMUST00000035167.2 ENSMUST00000035167.3 ENSMUST00000035167.4 ENSMUST00000035167.5 ENSMUST00000035167.6 ENSMUST00000035167.7 ENSMUST00000035167.8 ENSMUST00000035167.9 Kiaa2000 NM_028721 NPHP3_MOUSE Q69Z39 Q7TNH6 Q8C798 Q8C7Z3 Q9D6D1 uc012gzj.1 uc012gzj.2 uc012gzj.3 Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. Interacts with NPHP1 and INVS/NPHP2. Interacts (when myristoylated) with UNC119 and UNC119B; interaction is required for localization to cilium (By similarity). Interacts with CEP164 (By similarity). Component of a complex containing at least ANKS6, INVS, NEK8 and NPHP3. ANKS6 may organize complex assembly by linking INVS and NPHP3 to NEK8 and INVS may target the complex to the proximal ciliary axoneme (By similarity). Cell projection, cilium Note=Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus. Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q7TNH6-1; Sequence=Displayed; Name=2; IsoId=Q7TNH6-2; Sequence=VSP_014492, VSP_014493; In gastrulation-stage embryos, it is confined to the node between 7.5 and 8.25 dpc In sections of 14.5 and 16.5 dpc. embryos, it is strongly expressed in neural tissue (brain and ganglions). Also weakly expressed included in kidney tubules, retina, respiratory epithelium, biliary tract and liver. In the adult kidney, it is weakly but specifically expressed in distal tubules located at the cortico-medullary border, which corresponds to the site of cyst formation in mice lacking Nphp3. Expressed in retina and liver. Note=Defects in Nphp3 may be the cause of polycystic kidney disease (pcy). Pcy is a recessive disorder causing chronic renal failure. The Pcy phenotype can be slowed by diet modification such as protein restriction, administration of soy-based proteins, administration of methylprednisolone or treatment with V2R antagonist. In contrast administration of bicarbonate/citrate has no effect. Mice show situs inversus, congenital heart defects, and embryonic lethality. Sequence=BAB29319.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; Sequence=BAC33481.1; Type=Frameshift; Evidence=; Sequence=BAC34915.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; kidney development heart looping atrial septum development molecular_function cilium lipid metabolic process establishment or maintenance of cell polarity determination of left/right symmetry Wnt signaling pathway extracellular matrix organization lung development determination of pancreatic left/right asymmetry cell projection photoreceptor cell maintenance maintenance of animal organ identity convergent extension involved in gastrulation cilium assembly kidney morphogenesis determination of intestine left/right asymmetry determination of stomach left/right asymmetry determination of liver left/right asymmetry ureter development negative regulation of canonical Wnt signaling pathway ciliary inversin compartment ciliary base non-motile cilium assembly regulation of Wnt signaling pathway, planar cell polarity pathway uc012gzj.1 uc012gzj.2 uc012gzj.3 
ENSMUST00000035170.13 Dnajc13 ENSMUST00000035170.13 DnaJ heat shock protein family (Hsp40) member C13, transcript variant 2 (from RefSeq NM_001163026.1) Dnajc13 ENSMUST00000035170.1 ENSMUST00000035170.10 ENSMUST00000035170.11 ENSMUST00000035170.12 ENSMUST00000035170.2 ENSMUST00000035170.3 ENSMUST00000035170.4 ENSMUST00000035170.5 ENSMUST00000035170.6 ENSMUST00000035170.7 ENSMUST00000035170.8 ENSMUST00000035170.9 G3X922 G3X922_MOUSE NM_001163026 uc012gzk.1 uc012gzk.2 uc012gzk.3 molecular_function cytosol receptor-mediated endocytosis endosome organization endosome membrane early endosome membrane intracellular membrane-bounded organelle WASH complex regulation of early endosome to recycling endosome transport regulation of early endosome to late endosome transport uc012gzk.1 uc012gzk.2 uc012gzk.3 
ENSMUST00000035177.15 Mrpl3 ENSMUST00000035177.15 mitochondrial ribosomal protein L3, transcript variant 1 (from RefSeq NM_053159.4) ENSMUST00000035177.1 ENSMUST00000035177.10 ENSMUST00000035177.11 ENSMUST00000035177.12 ENSMUST00000035177.13 ENSMUST00000035177.14 ENSMUST00000035177.2 ENSMUST00000035177.3 ENSMUST00000035177.4 ENSMUST00000035177.5 ENSMUST00000035177.6 ENSMUST00000035177.7 ENSMUST00000035177.8 ENSMUST00000035177.9 NM_053159 Q3TF66 Q99N95 Q9CVE4 RM03_MOUSE uc009rht.1 uc009rht.2 uc009rht.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uL3 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation uc009rht.1 uc009rht.2 uc009rht.3 
ENSMUST00000035179.9 Nudt16 ENSMUST00000035179.9 nudix hydrolase 16 (from RefSeq NM_029385.2) ENSMUST00000035179.1 ENSMUST00000035179.2 ENSMUST00000035179.3 ENSMUST00000035179.4 ENSMUST00000035179.5 ENSMUST00000035179.6 ENSMUST00000035179.7 ENSMUST00000035179.8 NM_029385 NUD16_MOUSE Q6P3D0 Q9D716 uc009rhw.1 uc009rhw.2 uc009rhw.3 RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation (By similarity). Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Exhibits decapping activity towards NAD-capped RNAs and FAD-capped RNAs (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673). Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP; Xref=Rhea:RHEA:67484, Rhea:RHEA-COMP:15692, Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:63714, ChEBI:CHEBI:138282, ChEBI:CHEBI:156461; EC=3.6.1.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67485; Evidence=; Reaction=H2O + IDP = H(+) + IMP + phosphate; Xref=Rhea:RHEA:35207, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58053, ChEBI:CHEBI:58280; EC=3.6.1.64; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35208; Evidence=; Reaction=dIDP + H2O = dIMP + H(+) + phosphate; Xref=Rhea:RHEA:35211, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:61194, ChEBI:CHEBI:62286; EC=3.6.1.64; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35212; Evidence=; Reaction=a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'- end phospho-ribonucleoside in mRNA + H(+) + NAD(+); Xref=Rhea:RHEA:60880, Rhea:RHEA-COMP:15692, Rhea:RHEA-COMP:15698, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:138282, ChEBI:CHEBI:144029; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60881; Evidence=; Reaction=a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+); Xref=Rhea:RHEA:67588, Rhea:RHEA-COMP:15719, Rhea:RHEA-COMP:17275, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58210, ChEBI:CHEBI:144051, ChEBI:CHEBI:172372; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67589; Evidence=; Reaction=a 5'-end CoA-ribonucleoside in mRNA + H2O = (R)-4'- phosphopantetheine + a 5'-end phospho-adenosine-phospho- ribonucleoside in mRNA + 2 H(+); Xref=Rhea:RHEA:67592, Rhea:RHEA- COMP:15719, Rhea:RHEA-COMP:17276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:61723, ChEBI:CHEBI:144051, ChEBI:CHEBI:172371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67593; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Note=Binds 3 or 4 divalent metal cations. Acts specifically on U8 snoRNA with magnesium as cofactor. Has broad substrate specificity with bound manganese or cobalt (in vitro). ; Homodimer. Nucleus Nucleus, nucleolus Nucleus, nucleoplasm Cytoplasm Note=Localized predominantly in the cytoplasm. Localized in nucleolus, and in a minor proportion in distinct foci in the nucleoplasm. Expressed in brain, testis, spleen, lung, heart, liver, kidney and muscle (at protein level). Belongs to the Nudix hydrolase family. NUDT16 subfamily. Sequence=BAB26469.1; Type=Frameshift; Evidence=; nucleotide binding magnesium ion binding RNA binding mRNA binding GTP binding nucleus nucleoplasm nucleolus cytoplasm adenosine to inosine editing mRNA catabolic process proteolysis metalloexopeptidase activity positive regulation of cell proliferation nucleotide metabolic process snoRNA catabolic process dephosphorylation hydrolase activity manganese ion binding snoRNA binding chloride ion binding dITP catabolic process dITP diphosphatase activity identical protein binding protein homodimerization activity IDP catabolic process metal ion binding m7G(5')pppN diphosphatase activity cobalt ion binding chromosome organization positive regulation of cell cycle process RNA phosphodiester bond hydrolysis, endonucleolytic nucleotide phosphatase activity, acting on free nucleotides XDP catabolic process XTP binding ITP binding phosphodiesterase decapping endonuclease activity negative regulation of rRNA processing positive regulation of double-strand break repair uc009rhw.1 uc009rhw.2 uc009rhw.3 
ENSMUST00000035180.5 Nudt16l2 ENSMUST00000035180.5 nudix hydrolase 16 like 2 (from RefSeq NM_028562.3) 1700080E11Rik E9Q9G1 E9Q9G1_MOUSE ENSMUST00000035180.1 ENSMUST00000035180.2 ENSMUST00000035180.3 ENSMUST00000035180.4 NM_028562 Nudt16l2 uc012gzn.1 uc012gzn.2 uc012gzn.3 Reaction=H2O + IDP = H(+) + IMP + phosphate; Xref=Rhea:RHEA:35207, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58053, ChEBI:CHEBI:58280; EC=3.6.1.64; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35208; Evidence=; Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP; Xref=Rhea:RHEA:67484, Rhea:RHEA-COMP:15692, Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:63714, ChEBI:CHEBI:138282, ChEBI:CHEBI:156461; EC=3.6.1.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67485; Evidence=; Reaction=dIDP + H2O = dIMP + H(+) + phosphate; Xref=Rhea:RHEA:35211, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:61194, ChEBI:CHEBI:62286; EC=3.6.1.64; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35212; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Nucleus, nucleolus Nucleus, nucleoplasm Belongs to the Nudix hydrolase family. NUDT16 subfamily. nucleus mRNA catabolic process snoRNA catabolic process dephosphorylation hydrolase activity snoRNA binding m7G(5')pppN diphosphatase activity RNA phosphodiester bond hydrolysis, endonucleolytic nucleotide phosphatase activity, acting on free nucleotides phosphodiesterase decapping endonuclease activity uc012gzn.1 uc012gzn.2 uc012gzn.3 
ENSMUST00000035181.10 Aste1 ENSMUST00000035181.10 asteroid homolog 1, transcript variant 4 (from RefSeq NR_152139.1) ASTE1_MOUSE ENSMUST00000035181.1 ENSMUST00000035181.2 ENSMUST00000035181.3 ENSMUST00000035181.4 ENSMUST00000035181.5 ENSMUST00000035181.6 ENSMUST00000035181.7 ENSMUST00000035181.8 ENSMUST00000035181.9 NR_152139 Q4KMN1 Q80VC2 Q8BIR2 uc009ric.1 uc009ric.2 uc009ric.3 uc009ric.4 Possible role in EGF receptor signaling. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BIR2-1; Sequence=Displayed; Name=2; IsoId=Q8BIR2-2; Sequence=VSP_029285, VSP_029286; Belongs to the asteroid family. Sequence=AAH48866.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc009ric.1 uc009ric.2 uc009ric.3 uc009ric.4 
ENSMUST00000035194.8 Mapkapk3 ENSMUST00000035194.8 mitogen-activated protein kinase-activated protein kinase 3, transcript variant 1 (from RefSeq NM_178907.4) B0QZU7 E9QNE1 ENSMUST00000035194.1 ENSMUST00000035194.2 ENSMUST00000035194.3 ENSMUST00000035194.4 ENSMUST00000035194.5 ENSMUST00000035194.6 ENSMUST00000035194.7 MAPK3_MOUSE NM_178907 Q3T9E6 Q3UMW7 Q8K0G3 uc009rky.1 uc009rky.2 Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post- transcriptionally: acts by phosphorylating AU-rich elements (AREs)- binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Activated following phosphorylation by p38- alpha/MAPK14 following various stresses. Inhibited by ligand 5B (2'-[2- (1,3-benzodioxol-5-yl)pyrimidin-4-yl]-5',6'-dihydrospiro[piperidine- 4,7'-pyrrolo[3,2-c]pyridin]- 4'(1'h)-one) and ligand P4O (2-[2-(2- fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro- 4h-pyrrolo[3,2- c]pyridin-4-one), 2 ATP-competitive inhibitors (By similarity). Heterodimer with p38-alpha/MAPK14. The heterodimer with p38- alpha/MAPK14 forms a stable complex: molecules are positioned 'face to face' so that the ATP-binding sites of both kinases are at the heterodimer interface. Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4 (By similarity). [Isoform 1]: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm. [Isoform 3]: Nucleus. Cytoplasm. Note=Localizes throughout the cell. Degraded in response to osmotic stress. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UMW7-1; Sequence=Displayed; Name=2; IsoId=Q3UMW7-2; Sequence=VSP_016386, VSP_016387; Name=3; Synonyms=MK3.2; IsoId=Q3UMW7-3; Sequence=VSP_042175, VSP_042176; Ubiquitously expressed (at protein level). Isoform 3 is expressed in skeletal muscles and heart. Phosphorylated and activated by MAPK1/ERK2 and MAPK3/ERK1 (By similarity). Phosphorylated and activated by MAP kinase p38- alpha/MAPK14 at Thr-201, Ser-251 and Thr-313. Isoform 3 is degraded following phosphorylation at Thr-203. No visible phenotype. Mice are fertile and do not exhibit behavioral phenotype. Mice do not show decreased production of inflammatory cytokines such as TNF and IL6 upon LPS-stimulation. Mice lacking both Mapkapk2 and Mapkapk3 show further reduction of TNF production, compared to mice lacking only Mapkapk2. These data suggest that Mapkapk3 may function additively in stress-induced cytokine production. MAPKAPK3 knockdown homozygous mice develop Bruch's membrane abnormal thickening and thinning progressing with age (PubMed:26744326). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding toll-like receptor signaling pathway protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity calmodulin binding ATP binding nucleus nucleoplasm cytoplasm protein phosphorylation calcium-dependent protein serine/threonine kinase activity kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation response to lipopolysaccharide response to cytokine intracellular signal transduction macropinocytosis protein autophosphorylation mitogen-activated protein kinase binding uc009rky.1 uc009rky.2 
ENSMUST00000035196.14 Hemk1 ENSMUST00000035196.14 HemK methyltransferase family member 1 (from RefSeq NM_133984.2) B0QZU8 ENSMUST00000035196.1 ENSMUST00000035196.10 ENSMUST00000035196.11 ENSMUST00000035196.12 ENSMUST00000035196.13 ENSMUST00000035196.2 ENSMUST00000035196.3 ENSMUST00000035196.4 ENSMUST00000035196.5 ENSMUST00000035196.6 ENSMUST00000035196.7 ENSMUST00000035196.8 ENSMUST00000035196.9 HEMK1_MOUSE NM_133984 Q921L7 uc009rle.1 uc009rle.2 uc009rle.3 uc009rle.4 N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L. Reaction=L-glutaminyl-[peptide chain release factor] + S-adenosyl-L- methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42896, Rhea:RHEA- COMP:10271, Rhea:RHEA-COMP:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:30011, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61891; EC=2.1.1.297; Evidence=; Mitochondrion Belongs to the protein N5-glutamine methyltransferase family. nucleic acid binding mitochondrion protein methylation biological_process methyltransferase activity protein methyltransferase activity transferase activity methylation uc009rle.1 uc009rle.2 uc009rle.3 uc009rle.4 
ENSMUST00000035202.4 Mon1a ENSMUST00000035202.4 MON1 homolog A, secretory traffciking associated (from RefSeq NM_028369.3) A0A0R4J0D5 A0A0R4J0D5_MOUSE ENSMUST00000035202.1 ENSMUST00000035202.2 ENSMUST00000035202.3 Mon1a NM_028369 uc009rng.1 uc009rng.2 uc009rng.3 uc009rng.4 Plays an important role in membrane trafficking through the secretory apparatus. Belongs to the MON1/SAND family. guanyl-nucleotide exchange factor activity protein targeting to vacuole Mon1-Ccz1 complex uc009rng.1 uc009rng.2 uc009rng.3 uc009rng.4 
ENSMUST00000035203.9 Mst1r ENSMUST00000035203.9 macrophage stimulating 1 receptor (c-met-related tyrosine kinase), transcript variant 1 (from RefSeq NM_009074.3) E9QMZ4 ENSMUST00000035203.1 ENSMUST00000035203.2 ENSMUST00000035203.3 ENSMUST00000035203.4 ENSMUST00000035203.5 ENSMUST00000035203.6 ENSMUST00000035203.7 ENSMUST00000035203.8 NM_009074 Q62190 Q62555 RON_MOUSE Ron Stk uc009rni.1 uc009rni.2 uc009rni.3 This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity. Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion. Isoform sf-Stk forms covalent heterodimers with friend spleen focus-forming virus (FSFFV) gp55. Membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=2; Name=RON; IsoId=Q62190-1; Sequence=Displayed; Name=sf-Stk; IsoId=Q62190-2; Sequence=Not described; Expressed in liver, skin, lung, brain, testis and kidney. Proteolytic processing yields the two subunits. Autophosphorylated in response to ligand binding on Tyr-1215 and Tyr-1216 in the kinase domain leading to further phosphorylation of Tyr-1330 and Tyr-1337 in the C-terminal multifunctional docking site. Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity). O-mannosylation of IPT/TIG domains on Thr or Ser residues by TMEM260 is required for protein maturation. O-mannosylated residues are composed of single mannose glycans that are not elongated or modified. Mice show increased inflammation in an IFN-gamma- mediated delayed-type hypersensitivity reaction and increased susceptibility to lipopolysaccharide-induced endotoxic shock. Interaction with FSFFV envelope-like membrane glycoprotein gp55 results in constitutive tyrosine phosphorylation and activation of isoform sf-Stk. [Isoform sf-Stk]: Lacks part of the extracellular domain, oligomerizes and is constitutively activated. This isoform confers host susceptibility to Friend disease. Belongs to the protein kinase superfamily. Tyr protein kinase family. nucleotide binding stress fiber immune system process protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding vacuole plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway response to virus basal plasma membrane membrane integral component of membrane viral process kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation enzyme binding receptor complex positive regulation of MAP kinase activity innate immune response positive regulation of protein kinase B signaling uc009rni.1 uc009rni.2 uc009rni.3 
ENSMUST00000035208.14 Bsn ENSMUST00000035208.14 bassoon (from RefSeq NM_007567.2) BSN_MOUSE Bsn E9QMZ3 ENSMUST00000035208.1 ENSMUST00000035208.10 ENSMUST00000035208.11 ENSMUST00000035208.12 ENSMUST00000035208.13 ENSMUST00000035208.2 ENSMUST00000035208.3 ENSMUST00000035208.4 ENSMUST00000035208.5 ENSMUST00000035208.6 ENSMUST00000035208.7 ENSMUST00000035208.8 ENSMUST00000035208.9 Kiaa0434 NM_007567 O88737 Q6ZQB5 uc009rov.1 uc009rov.2 uc009rov.3 Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12628168, PubMed:12628169, PubMed:19812333). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity) (PubMed:28231469). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Interacts with PCLO, ERC2/CAST1, RIMS1 and UNC13A (PubMed:19812333). Interacts with TPRG1L (PubMed:17869247). Interacts with DYNLL1 and DYNLL2; these interactions potentially link PTVs to dynein and myosin V motor complexes (By similarity). Interacts with ATG5; this interaction is important for the regulation of presynaptic autophagy (PubMed:28231469). Interacts (via C-terminus) with TRIO (via N-terminus) (By similarity). Interacts with CTBP1 (By similarity). Interacts with SIAH1; this interaction negatively regulates SIAH1 E3 ligase activity (By similarity). Cytoplasm Presynaptic active zone toplasm, cytoskeleton Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein Note=In retina, is localized in the outer plexiform layer at ribbon synapses formed by rods and cones but was absent from basal synaptic contacts formed by cones. In the retinal inner plexiform layer localized to conventional inhibitory GABAergic synapses, made by amacrine cells, but absent from the bipolar cell ribbon synapses (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88737-1; Sequence=Displayed; Name=2; IsoId=O88737-2; Sequence=VSP_011375; Expressed in brain and retina. Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization (By similarity). Mice show a reduced excitability attributed to inactivation of a fraction of brain glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers, but were unable to fuse. In retina, mutants lacking functional BSN showed normal retinal anatomy, but synapses lacked anchoring of the photoreceptor ribbon to the presynaptic active zone resulting in impaired photoreceptor synaptic transmission (PubMed:12628168). Knockdown of both Bassoon/BSN and Piccolo/PCLO leads to the formation of presynaptic autophagosomes. [Isoform 2]: Incompl. transcription corepressor binding protein binding cytoplasm Golgi-associated vesicle trans-Golgi network cytoskeleton synapse assembly synaptic vesicle axo-dendritic transport retrograde axonal transport cell surface postsynaptic density membrane extrinsic component of membrane cell junction axon dendrite synaptic vesicle membrane cytoplasmic vesicle protein localization to synapse neuron projection neuronal cell body neuron projection terminus synapse dynein light chain binding metal ion binding presynaptic active zone cytoskeleton of presynaptic active zone maintenance of presynaptic active zone structure synapse organization excitatory synapse inhibitory synapse ribbon synapse presynapse presynaptic active zone cytoplasmic component structural constituent of presynaptic active zone glutamatergic synapse GABA-ergic synapse presynapse to nucleus signaling pathway presynaptic active zone assembly axon cytoplasm regulation of ubiquitin protein ligase activity piccolo-bassoon transport vesicle synaptic membrane integral component of membrane uc009rov.1 uc009rov.2 uc009rov.3 
ENSMUST00000035214.11 Ip6k1 ENSMUST00000035214.11 inositol hexaphosphate kinase 1 (from RefSeq NM_013785.2) ENSMUST00000035214.1 ENSMUST00000035214.10 ENSMUST00000035214.2 ENSMUST00000035214.3 ENSMUST00000035214.4 ENSMUST00000035214.5 ENSMUST00000035214.6 ENSMUST00000035214.7 ENSMUST00000035214.8 ENSMUST00000035214.9 IP6K1_MOUSE Ihpk1 NM_013785 Q6PD10 Q9QXV6 uc009roc.1 uc009roc.2 uc009roc.3 Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Reaction=1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo- inositol 1,2,3,4,6-pentakisphosphate + ADP; Xref=Rhea:RHEA:12793, ChEBI:CHEBI:30616, ChEBI:CHEBI:58130, ChEBI:CHEBI:58628, ChEBI:CHEBI:456216; EC=2.7.4.21; Reaction=1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP; Xref=Rhea:RHEA:37467, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:74946, ChEBI:CHEBI:77983, ChEBI:CHEBI:456216; EC=2.7.4.21; Cytoplasm Nucleus Highly expressed in brain and testis. Detected at much lower levels in heart, kidney, liver, lung and spleen. Belongs to the inositol phosphokinase (IPK) family. nucleotide binding inositol hexakisphosphate kinase activity inositol hexakisphosphate 5-kinase activity fibrillar center ATP binding nucleus cytoplasm cytosol inositol metabolic process kinase activity phosphorylation transferase activity inositol phosphate biosynthetic process phosphatidylinositol phosphorylation inositol hexakisphosphate 1-kinase activity inositol hexakisphosphate 3-kinase activity uc009roc.1 uc009roc.2 uc009roc.3 
ENSMUST00000035216.11 Uba7 ENSMUST00000035216.11 ubiquitin-like modifier activating enzyme 7 (from RefSeq NM_023738.4) ENSMUST00000035216.1 ENSMUST00000035216.10 ENSMUST00000035216.2 ENSMUST00000035216.3 ENSMUST00000035216.4 ENSMUST00000035216.5 ENSMUST00000035216.6 ENSMUST00000035216.7 ENSMUST00000035216.8 ENSMUST00000035216.9 NM_023738 Q9DBK7 UBA7_MOUSE Uba7 Ube1l uc009rno.1 uc009rno.2 uc009rno.3 E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferons stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation. Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus or rotavirus (PubMed:19004958, PubMed:31974171). Protein modification; protein ubiquitination. Cytoplasm Nucleus Ubiquitinated by RNF170. UBA7-deletion mice display increased susceptibility to viral infection. Belongs to the ubiquitin-activating E1 family. ubiquitin-protein transferase activity cytoplasm cellular protein modification process small protein activating enzyme activity protein ubiquitination ISG15 activating enzyme activity modification-dependent protein catabolic process ISG15-protein conjugation protein modification by small protein conjugation uc009rno.1 uc009rno.2 uc009rno.3 
ENSMUST00000035218.9 Nckipsd ENSMUST00000035218.9 NCK interacting protein with SH3 domain, transcript variant 2 (from RefSeq NR_185295.1) ENSMUST00000035218.1 ENSMUST00000035218.2 ENSMUST00000035218.3 ENSMUST00000035218.4 ENSMUST00000035218.5 ENSMUST00000035218.6 ENSMUST00000035218.7 ENSMUST00000035218.8 NR_185295 Q3UYF3 Q68G72 Q9ESJ4 SPN90_MOUSE Spin90 Wasbp uc009rqz.1 uc009rqz.2 uc009rqz.3 Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1) (By similarity). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomere and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Associates with the intermediate filaments, vimentin and desmin (By similarity). Binds the first and third SH3 domains of NCK (By similarity). Binds the proline-rich domains of N-WASP through its SH3 domain. Similarly, binds diaphanous protein homolog 1 (DRF1) (By similarity). Binds the SH3 domains of GRB2 through its proline-rich domains. Interacts with FASLG (By similarity). Nucleus Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes. nucleus COP9 signalosome positive regulation of neuron projection development SH3 domain binding uc009rqz.1 uc009rqz.2 uc009rqz.3 
ENSMUST00000035220.12 Prkar2a ENSMUST00000035220.12 protein kinase, cAMP dependent regulatory, type II alpha (from RefSeq NM_008924.3) ENSMUST00000035220.1 ENSMUST00000035220.10 ENSMUST00000035220.11 ENSMUST00000035220.2 ENSMUST00000035220.3 ENSMUST00000035220.4 ENSMUST00000035220.5 ENSMUST00000035220.6 ENSMUST00000035220.7 ENSMUST00000035220.8 ENSMUST00000035220.9 NM_008924 Prkar2a Q8K1M3 Q8K1M3_MOUSE uc009rqt.1 uc009rqt.2 uc009rqt.3 uc009rqt.4 Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. Cell membrane Membrane Belongs to the cAMP-dependent kinase regulatory chain family. nucleotide binding regulation of protein phosphorylation cAMP-dependent protein kinase inhibitor activity cytoplasm centrosome plasma membrane axoneme cAMP-dependent protein kinase complex cAMP-dependent protein kinase regulator activity kinase activity phosphorylation protein domain specific binding cAMP binding nucleotide-activated protein kinase complex ubiquitin protein ligase binding macromolecular complex protein kinase A catalytic subunit binding plasma membrane raft negative regulation of cAMP-dependent protein kinase activity uc009rqt.1 uc009rqt.2 uc009rqt.3 uc009rqt.4 
ENSMUST00000035222.6 Slc25a20 ENSMUST00000035222.6 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 (from RefSeq NM_020520.5) Cac Cact ENSMUST00000035222.1 ENSMUST00000035222.2 ENSMUST00000035222.3 ENSMUST00000035222.4 ENSMUST00000035222.5 MCAT_MOUSE NM_020520 Q3U801 Q9Z2Z6 Slc25a20 uc009rqs.1 uc009rqs.2 Mediates the electroneutral exchange of acylcarnitines (O- acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)- carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism. Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation. Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange). Reaction=(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) = (R)- carnitine(in) + O-acetyl-(R)-carnitine(out); Xref=Rhea:RHEA:49908, ChEBI:CHEBI:16347, ChEBI:CHEBI:57589; Evidence=; Reaction=(R)-carnitine(out) + O-acyl-(R)-carnitine(in) = (R)- carnitine(in) + O-acyl-(R)-carnitine(out); Xref=Rhea:RHEA:49924, ChEBI:CHEBI:16347, ChEBI:CHEBI:75659; Evidence=; Reaction=(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) = (R)- carnitine(in) + O-propanoyl-(R)-carnitine(out); Xref=Rhea:RHEA:49912, ChEBI:CHEBI:16347, ChEBI:CHEBI:53210; Evidence=; Reaction=(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) = (R)- carnitine(in) + O-hexadecanoyl-(R)-carnitine(out); Xref=Rhea:RHEA:49916, ChEBI:CHEBI:16347, ChEBI:CHEBI:17490; Evidence=; Reaction=(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) = (R)- carnitine(in) + O-octanoyl-(R)-carnitine(out); Xref=Rhea:RHEA:49920, ChEBI:CHEBI:16347, ChEBI:CHEBI:18102; Evidence=; Reaction=(R)-carnitine(in) = (R)-carnitine(out); Xref=Rhea:RHEA:34959, ChEBI:CHEBI:16347; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Widely expressed, with highest levels in the liver, intermediate levels in heart, testis and kidney and low levels in brain, including cortex, cerebellum, hippocampus and hypothalamus. Belongs to the mitochondrial carrier (TC 2.A.29) family. in utero embryonic development mitochondrion mitochondrial inner membrane cytosol acyl carnitine transmembrane transporter activity membrane integral component of membrane carnitine transmembrane transport acyl carnitine transmembrane transport uc009rqs.1 uc009rqs.2 
ENSMUST00000035227.8 Nicn1 ENSMUST00000035227.8 nicolin 1, transcript variant 1 (from RefSeq NM_025449.4) ENSMUST00000035227.1 ENSMUST00000035227.2 ENSMUST00000035227.3 ENSMUST00000035227.4 ENSMUST00000035227.5 ENSMUST00000035227.6 ENSMUST00000035227.7 NICN1_MOUSE NM_025449 Q9CQM0 uc009rpb.1 uc009rpb.2 uc009rpb.3 Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Nucleus High expression level is found in brain, testis, liver and kidney. Weak expression in spleen, leukocytes, small intestin and colon. Detected in all tissues of the developing embryos. molecular_function nucleus nucleoplasm cytosol microtubule biological_process protein polyglutamylation uc009rpb.1 uc009rpb.2 uc009rpb.3 
ENSMUST00000035230.7 Amt ENSMUST00000035230.7 aminomethyltransferase (from RefSeq NM_001013814.2) Amt ENSMUST00000035230.1 ENSMUST00000035230.2 ENSMUST00000035230.3 ENSMUST00000035230.4 ENSMUST00000035230.5 ENSMUST00000035230.6 GCST_MOUSE NM_001013814 Q8CFA2 uc009rpc.1 uc009rpc.2 uc009rpc.3 The glycine cleavage system catalyzes the degradation of glycine. Reaction=(6S)-5,6,7,8-tetrahydrofolate + N(6)-[(R)-S(8)- aminomethyldihydrolipoyl]-L-lysyl-[protein] = (6R)-5,10-methylene- 5,6,7,8-tetrahydrofolate + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NH4(+); Xref=Rhea:RHEA:16945, Rhea:RHEA-COMP:10475, Rhea:RHEA- COMP:10492, ChEBI:CHEBI:15636, ChEBI:CHEBI:28938, ChEBI:CHEBI:57453, ChEBI:CHEBI:83100, ChEBI:CHEBI:83143; EC=2.1.2.10; Evidence=; The glycine cleavage system is composed of four proteins: P, T, L and H. Mitochondrion Belongs to the GcvT family. aminomethyltransferase activity nucleoplasm mitochondrion glycine catabolic process transaminase activity transferase activity glycine decarboxylation via glycine cleavage system methylation uc009rpc.1 uc009rpc.2 uc009rpc.3 
ENSMUST00000035234.6 1700102P08Rik ENSMUST00000035234.6 RIKEN cDNA 1700102P08 gene (from RefSeq NM_053216.3) A0A0R4J0D7 CC062_MOUSE ENSMUST00000035234.1 ENSMUST00000035234.2 ENSMUST00000035234.3 ENSMUST00000035234.4 ENSMUST00000035234.5 NM_053216 Q6P8V6 Q9D9C7 uc009rpk.1 uc009rpk.2 uc009rpk.3 uc009rpk.4 Essential for normal spermatogenesis and male fertility. Testis-specific. Highly expressed in spermatocytes (at protein level). Male mice are infertile with smaller testis and epididymis, but female mice retain normal fertility (PubMed:31930642). Spermatogenesis in the male mouse is arrested at the spermatocyte stage, and no sperm is found in the epididymis (PubMed:31930642). Germ cells apoptosis is increased without changes to the serum concentration of testosterone, LH, and FSH or synapsis and recombination during meiosis (PubMed:31930642). molecular_function cellular_component biological_process uc009rpk.1 uc009rpk.2 uc009rpk.3 uc009rpk.4 
ENSMUST00000035240.7 Armc7 ENSMUST00000035240.7 armadillo repeat containing 7, transcript variant 1 (from RefSeq NM_177778.5) ARMC7_MOUSE ENSMUST00000035240.1 ENSMUST00000035240.2 ENSMUST00000035240.3 ENSMUST00000035240.4 ENSMUST00000035240.5 ENSMUST00000035240.6 NM_177778 Q3UJZ3 Q8R599 uc007mht.1 uc007mht.2 uc007mht.3 As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Component of the minor spliceosome. Within this complex, interacts with RBM48. biological_process uc007mht.1 uc007mht.2 uc007mht.3 
ENSMUST00000035242.9 Rab24 ENSMUST00000035242.9 RAB24, member RAS oncogene family (from RefSeq NM_009000.3) ENSMUST00000035242.1 ENSMUST00000035242.2 ENSMUST00000035242.3 ENSMUST00000035242.4 ENSMUST00000035242.5 ENSMUST00000035242.6 ENSMUST00000035242.7 ENSMUST00000035242.8 NM_009000 Q0PD31 Q0PD31_MOUSE Rab24 uc007qqk.1 uc007qqk.2 uc007qqk.3 Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding uc007qqk.1 uc007qqk.2 uc007qqk.3 
ENSMUST00000035258.10 Ms4a4b ENSMUST00000035258.10 membrane-spanning 4-domains, subfamily A, member 4B (from RefSeq NM_021718.2) ENSMUST00000035258.1 ENSMUST00000035258.2 ENSMUST00000035258.3 ENSMUST00000035258.4 ENSMUST00000035258.5 ENSMUST00000035258.6 ENSMUST00000035258.7 ENSMUST00000035258.8 ENSMUST00000035258.9 Ms4a4b NM_021718 Q9ES61 Q9ES61_MOUSE uc008gsf.1 uc008gsf.2 uc008gsf.3 uc008gsf.4 uc008gsf.5 Belongs to the MS4A family. integral component of plasma membrane membrane integral component of membrane uc008gsf.1 uc008gsf.2 uc008gsf.3 uc008gsf.4 uc008gsf.5 
ENSMUST00000035264.9 Pak5 ENSMUST00000035264.9 p21 (RAC1) activated kinase 5, transcript variant 1 (from RefSeq NM_001360382.1) ENSMUST00000035264.1 ENSMUST00000035264.2 ENSMUST00000035264.3 ENSMUST00000035264.4 ENSMUST00000035264.5 ENSMUST00000035264.6 ENSMUST00000035264.7 ENSMUST00000035264.8 NM_001360382 PAK5_MOUSE Pak5 Pak7 Q3TQJ7 Q6RWS7 Q8C015 uc008moi.1 uc008moi.2 uc008moi.3 Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with MARK2, leading to inhibit MARK2 independently of kinase activity. Interacts with RHOD and RHOH (By similarity). Mitochondrion Cytoplasm Nucleus Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival. Highly expressed in brain and eye. Also expressed in adrenal gland, pancreas, prostate and testes. Within the brain, expression is restricted to neurons. Present in brain but not in kidney, lung and spleen (at protein level). Expressed in fetal brain. An autoinhibitory domain is present in the N-terminal region of the protein. Autophosphorylated when activated by CDC42/p21. Mice are viable and fertile, and show normal development of brain, eye, pancreas and adrenal gland. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleoplasm cytoplasm mitochondrion protein phosphorylation apoptotic process cytoskeleton organization learning memory locomotory behavior kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation activation of protein kinase activity synapse negative regulation of extrinsic apoptotic signaling pathway uc008moi.1 uc008moi.2 uc008moi.3 
ENSMUST00000035266.11 Igtp ENSMUST00000035266.11 interferon gamma induced GTPase (from RefSeq NM_018738.4) ENSMUST00000035266.1 ENSMUST00000035266.10 ENSMUST00000035266.2 ENSMUST00000035266.3 ENSMUST00000035266.4 ENSMUST00000035266.5 ENSMUST00000035266.6 ENSMUST00000035266.7 ENSMUST00000035266.8 ENSMUST00000035266.9 IRGM3_MOUSE Igtp Irgm3 J7PDL1 NM_018738 Q8C2M8 Q9DCE9 uc007jas.1 uc007jas.2 uc007jas.3 uc007jas.4 Immunity-related GTPase that plays important roles in host resistance to acute infection by protozoan, such as Toxoplasma gondii and Leishmania major (PubMed:10639151, PubMed:11500431, PubMed:12438372, PubMed:16940170, PubMed:18765738). Acts as a dynamin- like protein that binds to intracellular membranes and promotes remodeling and trafficking of those membranes (By similarity). Acts predominantly to restrict acute protozoan infection: expression is required in both hematopoietic and non-hematopoietic cellular compartments and is dependent on Stat1 (PubMed:12438372). Only plays a partial role in the control of latent Toxoplasma infection (PubMed:12438372). Involved in the clearance of acute protozoan infections by regulating autophagy, possibly by promoting the fusion of phagosomes with lysosomes for efficient degradation of vacuoles containing parasites (PubMed:16940170). Probably involved in membrane disruption of parasite-containing vacuoles (PubMed:18765738). In addition to its role in resistance to acute infection by protozoan, also acts as a negative regulator of the integrated stress response (ISR) following coxsackievirus B3 infection (PubMed:21981022). Promotes differentiation of activated CD8(+) T-cells (PubMed:25644000). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Endoplasmic reticulum Cytoplasmic vesicle membrane pid droplet Note=Delivered to the parasitophorous vacuole via the cell endoplasmic reticulum early after invasion (PubMed:18765738). It then condenses into vesicle-like structures on the vacuole just prior to parasitophorous vacuole disruption (PubMed:18765738). Mainly associates with lipid droplets and 'self' cytoplasmic vacuoles, while it only weakly coats 'non-self' pathogen- containing vacuoles (PubMed:23785284). Expression is induced in response to IFNG/IFN-gamma (PubMed:8702776, PubMed:11500431, PubMed:12438372). Expressed in response to Toxoplasma gondii infection (PubMed:12438372). Mice do not show obvious abnormalities, but are more susceptible to infection by Toxoplasma gondii (PubMed:10639151, PubMed:11500431). In contrast, normal clearance of Listeria monocytogenes and cytomegalovirus infections is observed (PubMed:10639151). Macrophages from knockout mice show impaired envelopment of parasites in autophagosome-like vacuoles (PubMed:16940170). Mice lacking both Irgm1 and Igtp/Irgm3 display resistance to Mycobacterium tuberculosis infection compared to Irgm1 mice that are highly susceptible to infection (PubMed:36629440). Mice lacking Irgm1, Irgm2 and Igtp/Irgm3 (panIrgm mice) show resistance against M.tuberculosis one month post-infection; then, panIrgm mice display higher bacterial burden and altered cytokine during late stage of infection, leading to increased mortality (PubMed:36629440). Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. Sequence=CBY65995.1; Type=Erroneous gene model prediction; Evidence=; GTPase activity GTP binding endoplasmic reticulum membrane cytosol defense response membrane cellular response to interferon-beta uc007jas.1 uc007jas.2 uc007jas.3 uc007jas.4 
ENSMUST00000035269.15 Pygm ENSMUST00000035269.15 muscle glycogen phosphorylase (from RefSeq NM_011224.2) ENSMUST00000035269.1 ENSMUST00000035269.10 ENSMUST00000035269.11 ENSMUST00000035269.12 ENSMUST00000035269.13 ENSMUST00000035269.14 ENSMUST00000035269.2 ENSMUST00000035269.3 ENSMUST00000035269.4 ENSMUST00000035269.5 ENSMUST00000035269.6 ENSMUST00000035269.7 ENSMUST00000035269.8 ENSMUST00000035269.9 NM_011224 PYGM_MOUSE Pygm Q9WUB3 uc008gio.1 uc008gio.2 uc008gio.3 uc008gio.4 This gene encodes a glycolysis enzyme found in muscle. Highly similar enzymes encoded by different genes are found in liver and brain. The encoded protein is involved in regulating the breakdown of glycogen to glucose-1-phosphate, which is necessary for ATP generation. [provided by RefSeq, Dec 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF124787.1, BC012961.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. Reaction=[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate; Xref=Rhea:RHEA:41732, Rhea:RHEA-COMP:9584, Rhea:RHEA-COMP:9586, ChEBI:CHEBI:15444, ChEBI:CHEBI:43474, ChEBI:CHEBI:58601; EC=2.4.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41733; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Allosterically regulated through the non-covalent binding of metabolites, being activated by AMP and inhibited by ATP, ADP, and glucose-6-phosphate. The activity is also controlled by post- translational modifications including phosphorylation. Homodimer. Homotetramer; to form the enzymatically active phosphorylase A. Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A. Belongs to the glycogen phosphorylase family. nucleotide binding response to hypoxia catalytic activity phosphorylase activity cytoplasm carbohydrate metabolic process glycogen metabolic process glycogen catabolic process cellular calcium ion homeostasis drug binding metabolic process glycogen phosphorylase activity response to organic substance AMP binding sarcoplasmic reticulum transferase activity transferase activity, transferring glycosyl groups Z disc pyridoxal phosphate binding carbohydrate binding response to cAMP uc008gio.1 uc008gio.2 uc008gio.3 uc008gio.4 
ENSMUST00000035273.4 Prl3b1 ENSMUST00000035273.4 prolactin family 3, subfamily b, member 1 (from RefSeq NM_008865.4) Csh2 ENSMUST00000035273.1 ENSMUST00000035273.2 ENSMUST00000035273.3 Ghd8 NM_008865 Prl3b1 Q5SZY3 Q5SZY3_MOUSE uc007pxi.1 uc007pxi.2 uc007pxi.3 Secreted Belongs to the somatotropin/prolactin family. hormone activity extracellular region signal transduction uc007pxi.1 uc007pxi.2 uc007pxi.3 
ENSMUST00000035276.5 Dctpp1 ENSMUST00000035276.5 dCTP pyrophosphatase 1 (from RefSeq NM_023203.1) DCTP1_MOUSE Dctpp1 ENSMUST00000035276.1 ENSMUST00000035276.2 ENSMUST00000035276.3 ENSMUST00000035276.4 NM_023203 Q9QY93 Tdrg-TL1 uc009juw.1 uc009juw.2 uc009juw.3 uc009juw.4 Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. Reaction=dCTP + H2O = dCMP + diphosphate + H(+); Xref=Rhea:RHEA:22636, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:57566, ChEBI:CHEBI:61481; EC=3.6.1.12; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Probably binds two or three Mg(2+) ions per subunit. ; Inhibited by divalent calcium or cadmium ions. Kinetic parameters: KM=0.16 mM for 5-methyl-dCTP (at pH 9.0) ; KM=44 uM for dCTP (at pH 8.0) KM=118 uM for dATP (at pH 8.0) KM=407 uM for dTTP (at pH 8.0) KM=529 uM for CTP (at pH 8.0) KM=3.9 uM for 5-iodo-dCTP (at pH 8.0) KM=21.7 uM for 5-bromo-dCTP (at pH 8.0) KM=48.5 uM for 5-methyl-dCTP (at pH 8.0) ; KM=50 uM for 5-chloro-dCTP (at pH 8.0) Note=Activity is higher with 5-iodo-dCTP, followed by 5-bromo-dCTP, dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. pH dependence: Optimum pH is 9-9.5. Temperature dependence: Optimum temperature is 60 degrees Celsius. ; Homotetramer. Cytoplasm, cytosol Note=Not detected in mitochondrion and nucleus. Ubiquitous. Highly expressed in heart, liver, skeletal muscle, cerebellum, brain, and salivary gland. nucleotide binding magnesium ion binding cytoplasm cytosol dCTP catabolic process nucleoside triphosphate catabolic process pyrophosphatase activity hydrolase activity pyrimidine deoxyribonucleotide binding DNA protection identical protein binding metal ion binding nucleoside-triphosphate diphosphatase activity dCTP diphosphatase activity nucleus mitochondrion uc009juw.1 uc009juw.2 uc009juw.3 uc009juw.4 
ENSMUST00000035278.7 Marchf3 ENSMUST00000035278.7 membrane associated ring-CH-type finger 3, transcript variant 3 (from RefSeq NM_001374228.1) ENSMUST00000035278.1 ENSMUST00000035278.2 ENSMUST00000035278.3 ENSMUST00000035278.4 ENSMUST00000035278.5 ENSMUST00000035278.6 F8WJC4 F8WJC4_MOUSE March3 Marchf3 NM_001374228 uc289per.1 uc289per.2 E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Cytoplasmic vesicle membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein zinc ion binding membrane integral component of membrane metal ion binding uc289per.1 uc289per.2 
ENSMUST00000035288.17 Stab2 ENSMUST00000035288.17 stabilin 2 (from RefSeq NM_138673.3) ENSMUST00000035288.1 ENSMUST00000035288.10 ENSMUST00000035288.11 ENSMUST00000035288.12 ENSMUST00000035288.13 ENSMUST00000035288.14 ENSMUST00000035288.15 ENSMUST00000035288.16 ENSMUST00000035288.2 ENSMUST00000035288.3 ENSMUST00000035288.4 ENSMUST00000035288.5 ENSMUST00000035288.6 ENSMUST00000035288.7 ENSMUST00000035288.8 ENSMUST00000035288.9 Feel2 Hare NM_138673 Q8BM87 Q8R4U0 STAB2_MOUSE Stab2 uc007gqo.1 uc007gqo.2 uc007gqo.3 Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram- positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed short form also functions as an endocytosis receptor for heparin internalization as well as HA and CS. Interacts with heparin, alpha-M/beta-2 integrin (ITGAM and ITGB2), and thymosin beta 4 (TMSB4X) (By similarity). Interacts with GULP1. Associates with clathrin and adapter protein AP-2; in liver sinusoidal endothelial cells (LSECs). Cytoplasm Cell membrane ; Single-pass type I membrane protein Expressed in endothelial sinuses of liver, lymph nodes, bone marrow, spleen and in specialised structures of eye, heart, brain and kidney. Expression is detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal cells lining the ventricles in the brain, and in the prismatic epithelial cells covering the renal papillae. Recognizes phosphatidyl serine via its epidermal growth factor- like domains. Glycosylated. Proteolytically processed to yield a smaller protein. low-density lipoprotein receptor activity scavenger receptor activity calcium ion binding hyaluronic acid binding cytoplasm cytosol plasma membrane integral component of plasma membrane endocytosis cell adhesion external side of plasma membrane membrane integral component of membrane low-density lipoprotein particle binding defense response to bacterium defense response to Gram-positive bacterium uc007gqo.1 uc007gqo.2 uc007gqo.3 
ENSMUST00000035295.6 Degs1 ENSMUST00000035295.6 delta 4-desaturase, sphingolipid 1, transcript variant 1 (from RefSeq NM_007853.5) DEGS1_MOUSE Degs Degs1 Des1 ENSMUST00000035295.1 ENSMUST00000035295.2 ENSMUST00000035295.3 ENSMUST00000035295.4 ENSMUST00000035295.5 Mdes NM_007853 O09005 Q8R4H3 uc007dxw.1 uc007dxw.2 uc007dxw.3 Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Catalyzes the equilibrium isomerization of retinols (By similarity). Reaction=an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:46544, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:31488, ChEBI:CHEBI:52639; EC=1.14.19.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46545; Evidence=; Reaction=all-trans-retinol = 11-cis-retinol; Xref=Rhea:RHEA:19141, ChEBI:CHEBI:16302, ChEBI:CHEBI:17336; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19142; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:19143; Evidence=; Reaction=all-trans-retinol = 9-cis-retinol; Xref=Rhea:RHEA:55348, ChEBI:CHEBI:17336, ChEBI:CHEBI:78272; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55349; Evidence=; Reaction=all-trans-retinol = 13-cis-retinol; Xref=Rhea:RHEA:55352, ChEBI:CHEBI:17336, ChEBI:CHEBI:45479; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55353; Evidence=; Reaction=11-cis-retinol = 13-cis-retinol; Xref=Rhea:RHEA:55356, ChEBI:CHEBI:16302, ChEBI:CHEBI:45479; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55357; Evidence=; Reaction=11-cis-retinol = 9-cis-retinol; Xref=Rhea:RHEA:55360, ChEBI:CHEBI:16302, ChEBI:CHEBI:78272; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55361; Evidence=; Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1. Mitochondrion membrane Endoplasmic reticulum membrane ; Multi-pass membrane protein Detected in testis. Detected in pachytene spermatocytes and round spermatids. Expressed in retina and retinal pigment epithelium by Mueller cells (at protein level) (PubMed:23143414). Myristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels. Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. mitochondrion endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process membrane integral component of membrane oxidoreductase activity sphingolipid biosynthetic process sphingolipid delta-4 desaturase activity positive regulation of apoptotic process ceramide biosynthetic process oxidation-reduction process uc007dxw.1 uc007dxw.2 uc007dxw.3 
ENSMUST00000035300.7 Scgb1c1 ENSMUST00000035300.7 secretoglobin, family 1C, member 1 (from RefSeq NM_001099742.1) ENSMUST00000035300.1 ENSMUST00000035300.2 ENSMUST00000035300.3 ENSMUST00000035300.4 ENSMUST00000035300.5 ENSMUST00000035300.6 G5E8B5 G5E8B5_MOUSE NM_001099742 Scgb1c1 uc009kig.1 uc009kig.2 uc009kig.3 Secreted Belongs to the secretoglobin family. uc009kig.1 uc009kig.2 uc009kig.3 
ENSMUST00000035301.7 Atp6v1g1 ENSMUST00000035301.7 ATPase, H+ transporting, lysosomal V1 subunit G1 (from RefSeq NM_024173.2) Atp6g1 ENSMUST00000035301.1 ENSMUST00000035301.2 ENSMUST00000035301.3 ENSMUST00000035301.4 ENSMUST00000035301.5 ENSMUST00000035301.6 NM_024173 Q9CR51 VATG1_MOUSE uc008tgq.1 uc008tgq.2 uc008tgq.3 uc008tgq.4 Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Apical cell membrane Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level)(PubMed:29993276). Ubiquitous (PubMed:12527205). Belongs to the V-ATPase G subunit family. protein binding lysosomal membrane cytosol plasma membrane ion transport cellular iron ion homeostasis hydrogen-exporting ATPase activity, phosphorylative mechanism vacuolar proton-transporting V-type ATPase complex ATPase activity cellular response to increased oxygen levels ATPase activity, coupled to transmembrane movement of substances ATPase binding hydrogen ion transmembrane transport synaptic vesicle uc008tgq.1 uc008tgq.2 uc008tgq.3 uc008tgq.4 
ENSMUST00000035323.6 Spib ENSMUST00000035323.6 Spi-B transcription factor (Spi-1/PU.1 related) (from RefSeq NM_019866.1) ENSMUST00000035323.1 ENSMUST00000035323.2 ENSMUST00000035323.3 ENSMUST00000035323.4 ENSMUST00000035323.5 NM_019866 O35906 O35907 O35909 O55199 SPIB_MOUSE uc009gpw.1 uc009gpw.2 uc009gpw.3 Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. Required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. Can form homotypic interactions (By similarity). Interacts with IRF4/Pip (By similarity). Interacts with JUN (By similarity). Interacts with TBP (By similarity). May also interact with CREBBP and EP300 (By similarity). Interacts with NONO/p54(nrb) (PubMed:8626664). Nucleus Event=Alternative promoter usage, Alternative splicing; Named isoforms=3; Name=IA; IsoId=O35906-1; Sequence=Displayed; Name=IC; IsoId=O35906-2; Sequence=VSP_013908; Name=IIA; IsoId=O35906-3; Sequence=VSP_013907; Expressed in the medulla of the thymus, the spleen and germinal centers of the lymph nodes. Expressed in B-cells and T- cells, expression increases during B-cell maturation and decreases during T-cell maturation. The protein contains a weakly acidic N-terminal transactivation domain (TAD) followed by a second TAD rich in proline, serine and threonine. Each of these domains may be required for transcriptional activation of a subset of target genes (By similarity). [Isoform IA]: Produced by alternative promoter usage. [Isoform IC]: Produced by alternative splicing of isoform IA. [Isoform IIA]: Produced by alternative promoter usage. Belongs to the ETS family. RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell differentiation macrophage differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc009gpw.1 uc009gpw.2 uc009gpw.3 
ENSMUST00000035336.5 Il17rd ENSMUST00000035336.5 interleukin 17 receptor D, transcript variant 1 (from RefSeq NM_134437.4) B2RRY7 ENSMUST00000035336.1 ENSMUST00000035336.2 ENSMUST00000035336.3 ENSMUST00000035336.4 I17RD_MOUSE Il17rlm NM_134437 Q8JZL1 Q8K447 Q8R5J8 Sef uc007stl.1 uc007stl.2 uc007stl.3 Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation (PubMed:12604616). Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK (By similarity). Mediates JNK activation and may be involved in apoptosis (PubMed:15277532). May inhibit FGF- induced FGFR1 tyrosine phosphorylation (PubMed:12604616). Might have a role in the early stages of fate specification of GnRH-secreting neurons (PubMed:23643382). Inhibits TGFB-induced epithelial-to- mesenchymal transition in lens epithelial cells (PubMed:25576668). Self-associates. Interacts with FGFR2 and phosphorylated MAP2K1 or MAP2K2. Associates with a MAP2K1/2-MAPK1/3 complex (By similarity). Interacts with FGFR1 and MAP3K7. Golgi apparatus membrane ; Single- pass type I membrane protein Cell membrane ; Single-pass type I membrane protein Note=Associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=IL17RLM-L, Long; IsoId=Q8JZL1-1; Sequence=Displayed; Name=2; Synonyms=IL17RLM-S, Short; IsoId=Q8JZL1-2; Sequence=VSP_015585; During early embryogenesis, predominantly expressed at 6.5 dpc and 9.5 dpc in the forebrain, mid-hindbrain boundary, branchial arches, somites, limb bud and tailbud. At 12.5 dpc additionally expressed in the diencephalon, optic stalk, pituitary, olfactory and oral epithelium, tooth primordia, somites, developing metanephric kidney and stomach. Expressed in the neopallial cortex, rhombic lip and dorsal regions of the myelencephalon and in the frontal nasal process. Expressed in the commissural plate and septal area of the forebrain and in the hippocampus, lens and optic cup. In the oral region, expressed in the tongue and in the mesenchyme of the first branchial arch. Also expressed in the developing inner ear. Expression patterns remain essentially unchanged at 15.5 dpc, with the addition of a strong expression in the submandibular gland. Golgi membrane nucleic acid binding nucleoplasm Golgi apparatus plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway interleukin-17 receptor activity uc007stl.1 uc007stl.2 uc007stl.3 
ENSMUST00000035342.11 Adamts20 ENSMUST00000035342.11 ADAM metallopeptidase with thrombospondin type 1 motif 20, transcript variant 1 (from RefSeq NM_177431.6) ATS20_MOUSE E9QLA1 ENSMUST00000035342.1 ENSMUST00000035342.10 ENSMUST00000035342.2 ENSMUST00000035342.3 ENSMUST00000035342.4 ENSMUST00000035342.5 ENSMUST00000035342.6 ENSMUST00000035342.7 ENSMUST00000035342.8 ENSMUST00000035342.9 NM_177431 P59511 uc007xje.1 uc007xje.2 uc007xje.3 uc007xje.4 This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Certain mutations in this gene cause defective development of neural crest-derived melanoblasts resulting in a 'belted' phenotype that is characterized by white spots in the lumbar region. [provided by RefSeq, Jul 2016]. May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease- independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=ADAMTS20 B long isoform; IsoId=P59511-1; Sequence=Displayed; Name=2; Synonyms=ADAMTS20 A short isoform; IsoId=P59511-2; Sequence=VSP_007606, VSP_007607; Expressed at low level in testis and brain. The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2- G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3- glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). Note=Defects in Adamts20 are the cause of the belted (bt) phenotype. It is a pigmental defect which occurs as a result of a defect in melanocyte development. endopeptidase activity metalloendopeptidase activity extracellular region extracellular space proteolysis peptidase activity metallopeptidase activity zinc ion binding positive regulation of signal transduction hydrolase activity extracellular matrix organization negative regulation of apoptotic process positive regulation of melanocyte differentiation metal ion binding regulation of developmental pigmentation uc007xje.1 uc007xje.2 uc007xje.3 uc007xje.4 
ENSMUST00000035346.14 Nol4l ENSMUST00000035346.14 nucleolar protein 4-like, transcript variant 17 (from RefSeq NR_176616.1) 8430427H17Rik ENSMUST00000035346.1 ENSMUST00000035346.10 ENSMUST00000035346.11 ENSMUST00000035346.12 ENSMUST00000035346.13 ENSMUST00000035346.2 ENSMUST00000035346.3 ENSMUST00000035346.4 ENSMUST00000035346.5 ENSMUST00000035346.6 ENSMUST00000035346.7 ENSMUST00000035346.8 ENSMUST00000035346.9 NR_176616 Nol4l Q3UH85 Q3UH85_MOUSE uc008nhv.1 uc008nhv.2 uc008nhv.3 uc008nhv.4 nucleoplasm cytosol uc008nhv.1 uc008nhv.2 uc008nhv.3 uc008nhv.4 
ENSMUST00000035350.12 Aftph ENSMUST00000035350.12 aftiphilin, transcript variant 1 (from RefSeq NM_181411.4) AFTIN_MOUSE Afth ENSMUST00000035350.1 ENSMUST00000035350.10 ENSMUST00000035350.11 ENSMUST00000035350.2 ENSMUST00000035350.3 ENSMUST00000035350.4 ENSMUST00000035350.5 ENSMUST00000035350.6 ENSMUST00000035350.7 ENSMUST00000035350.8 ENSMUST00000035350.9 NM_181411 Q5SSE6 Q80WT5 Q99KJ1 uc007idh.1 uc007idh.2 uc007idh.3 uc007idh.4 uc007idh.5 uc007idh.6 Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity). Self-associates (By similarity). Interacts with GGA1 (via GAE domain) (By similarity). Interacts with GGA3 (via GAE domain), AP1G1 (via GAE domain) and AP1G2 (via GAE domain) (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, at least composed of AFTPH/aftiphilin, HEATR5B/p200a and SYNRG/gamma-synergin, which plays a role in the AP1G1/AP-1-mediated protein trafficking from early to recycling endosomes (By similarity). Within the complex interacts with HEATR5B/p200a and SYNRG/gamma-synergin; the interactions are direct (By similarity). Interacts with AP1G1/AP-1; the interaction is required to recruit AFTPH/aftiphilin to the perinuclear region of the cell (By similarity). Interacts with CLTCL1/Clathrin (By similarity). Cytoplasm Cytoplasm, perinuclear region Cytoplasmic vesicle, clathrin-coated vesicle Note=Co-localizes with AP1G1/AP-1 in the cytoplasm (By similarity). Recruited to the perinuclear region by AP1G1/AP-1 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80WT5-1; Sequence=Displayed; Name=2; IsoId=Q80WT5-2; Sequence=VSP_013242; The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity). Sequence=CAI24910.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAI25738.1; Type=Erroneous gene model prediction; Evidence=; nucleus cytoplasm Golgi apparatus cytosol protein transport AP-1 adaptor complex clathrin binding trans-Golgi network membrane intracellular membrane-bounded organelle intracellular transport uc007idh.1 uc007idh.2 uc007idh.3 uc007idh.4 uc007idh.5 uc007idh.6 
ENSMUST00000035351.7 Syt15 ENSMUST00000035351.7 synaptotagmin XV, transcript variant a (from RefSeq NM_181529.4) B2RTF1 ENSMUST00000035351.1 ENSMUST00000035351.2 ENSMUST00000035351.3 ENSMUST00000035351.4 ENSMUST00000035351.5 ENSMUST00000035351.6 NM_181529 Q7TN81 Q7TN82 Q8C6N3 Q8C999 SYT15_MOUSE uc007tan.1 uc007tan.2 uc007tan.3 uc007tan.4 May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Homodimer. Membrane; Single-pass type III membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Syt XV-a; IsoId=Q8C6N3-1; Sequence=Displayed; Name=2; Synonyms=Syt XV-b; IsoId=Q8C6N3-2; Sequence=VSP_008649, VSP_008650; Isoform 1 and isoform 2 are expressed in heart, lung, skeletal muscle and testis; not detected in brain, liver and kidney. Isoform 1 is expressed in spleen. Detected from 7 dpc. Neither C2 domains mediates Ca(2+)-dependent or Ca(2+)- independent phospholipid binding. [Isoform 2]: May be due to intron retention. Belongs to the synaptotagmin family. SNARE binding phosphatidylserine binding calcium ion binding calcium-dependent phospholipid binding plasma membrane regulation of dopamine secretion membrane integral component of membrane vesicle-mediated transport calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis extrinsic component of membrane clathrin binding exocytic vesicle cellular response to calcium ion uc007tan.1 uc007tan.2 uc007tan.3 uc007tan.4 
ENSMUST00000035371.9 Sv2a ENSMUST00000035371.9 synaptic vesicle glycoprotein 2a (from RefSeq NM_022030.3) ENSMUST00000035371.1 ENSMUST00000035371.2 ENSMUST00000035371.3 ENSMUST00000035371.4 ENSMUST00000035371.5 ENSMUST00000035371.6 ENSMUST00000035371.7 ENSMUST00000035371.8 Kiaa0736 NM_022030 Q80TT0 Q8R0R5 Q9JIS5 SV2A_MOUSE Sv2 uc008qmf.1 uc008qmf.2 uc008qmf.3 uc008qmf.4 Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin probably binds via extracellular loop 4 (PubMed:16543415). (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); BoNT/D does not bind to extracellular loop 4 as do BoNT/A and BoNT/E (PubMed:21483489). (Microbial infection) Receptor for C.botulinum neurotoxin type E (BoNT/E); the toxin probably binds via extracellular loop 4 (PubMed:18815274). It probably requires glycosylation of Asn-573 (PubMed:18815274). Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2 (By similarity). (Microbial infection) Interacts with C.botulinum neurotoxin type A (BoNT/A, botA). Presynapse Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals. Expressed in conventional synapses and cone ribbon synapses in the retina (at protein level) (PubMed:12687700). Expressed in diaphragm motor nerve terminals (at protein level) (PubMed:16543415). Expressed in hippocampus neurons (at protein level) (PubMed:18815274). Expressed during synaptogenesis in the retina (at protein level). Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1. N-glycosylated. Mice fail to grow, experience severe epileptic seizures and die immediately or shortly after birth probably due to multiple neural and endocrine deficits (PubMed:10624962). Mice lacking both Sv2a and Sv2b display a similar phenotype (PubMed:10624962). Diaphragm motor nerve terminals from mice with only a single copy of this gene and no Sv2b have decreased binding of C.botulinum neurotoxin type A (BoNT/A, botA) and are less sensitive to the toxin (PubMed:16543415). Hippocampal neurons from young mice lacking both Sv2a and Sv2b do not bind BoNT/A, nor do they take it up (PubMed:16543415, PubMed:18815274). Hippocampal neurons from young mice lacking both Sv2a and Sv2b do not bind C.botulinum neurotoxin type E (BoNT/E), nor do they take it up (PubMed:18815274). Hippocampal neurons from young mice lacking both Sv2a and Sv2b do not bind C.botulinum neurotoxin type BoNT/D (BoNT/D, botD), nor do they take it up (PubMed:21483489). Hippocampal neurons from young mice lacking both Sv2a and Sv2b take up C.botulinum neurotoxin type C (BoNT/C) and C.botulinum neurotoxin type F (BonT/F, botF) normally (PubMed:21483489). Belongs to the major facilitator superfamily. Sequence=BAC65642.3; Type=Frameshift; Evidence=; endoplasmic reticulum integral component of plasma membrane cell-cell junction neurotransmitter transport cellular calcium ion homeostasis chemical synaptic transmission synaptic vesicle regulation of gamma-aminobutyric acid secretion membrane integral component of membrane synaptic vesicle priming protein kinase binding transmembrane transporter activity cell junction integral component of synaptic vesicle membrane dendrite synaptic vesicle membrane cytoplasmic vesicle neuromuscular junction neuron projection neuronal cell body synapse presynaptic active zone transmembrane transport glutamatergic synapse GABA-ergic synapse uc008qmf.1 uc008qmf.2 uc008qmf.3 uc008qmf.4 
ENSMUST00000035372.3 Ascl3 ENSMUST00000035372.3 achaete-scute family bHLH transcription factor 3 (from RefSeq NM_020051.1) ASCL3_MOUSE ENSMUST00000035372.1 ENSMUST00000035372.2 Mash3 NM_020051 Q3SXE3 Q9JJR7 Sgn1 uc009jeb.1 uc009jeb.2 uc009jeb.3 Transcriptional repressor (PubMed:11784080). Inhibits myogenesis (PubMed:11784080). Plays a role in progenitor cells which differentiate into ductal and acinar, but not myoepithelial, cell lineages in the salivary glands (PubMed:18572159, PubMed:21377457). Involved in the functions of the microvillar cells and Bowman's glands and probably, in a non-cell-autonomous manner, in the development or regeneration of a complete olfactory epithelium (OE) (PubMed:27910949). Efficient DNA binding requires dimerization with another bHLH protein. Nucleus Expressed in the salivary duct cells (PubMed:11784080, PubMed:18572159). Also expressed at lower levels in testis and epididymis (PubMed:11784080). Expressed in the olfactory epithelium (OE), in a subset of apical microvillar cells (PubMed:27910949). Expressed throughout embryonic development at 12.5, 14.5, 16.5 and 18.5 days post coitum (dpc), in cells localized at the apical region of the developing olfactory epithelium (OE) (PubMed:27910949). Expressed transiently in the progenitors of the secretory microvillar cells and Bowman's glands in the OE, expression being abolished by 2 months of age (PubMed:27910949). Also expressed at the canalicular stage, at 15.5 days post coitum (dpc), in the large excretory duct of the developing salivary glands (PubMed:18572159). By the terminal bud stage, just prior to birth, at 17.5 dpc, expressed in a small number of cells in ductal structures of all three major salivary glands (PubMed:18572159). At three weeks of age, expressed in duct cells in the submandibular, sublingual and parotid glands (PubMed:18572159). Following injury of the olfactory epithelium (OE) in 3-4 week olds, up-regulated in the multipotent horizontal basal cells (HBCs) at between 1 and 28 days later. Viable and fertile (PubMed:21377457, PubMed:27910949). Salivary glands develop, but the submandibular glands are consistently smaller and overall levels of cell proliferation lower (PubMed:21377457). Expression of cation-chloride cotransporter Nkcc1 is dramatically reduced in salivary ducts (PubMed:21377457). No obvious morphological changes in the olfactory epithelium (OE) (PubMed:27910949). negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein binding nucleus transcription factor complex regulation of transcription from RNA polymerase II promoter transcription factor binding protein dimerization activity RNA polymerase II transcription factor complex transcription factor activity, sequence-specific DNA binding uc009jeb.1 uc009jeb.2 uc009jeb.3 
ENSMUST00000035390.7 Azgp1 ENSMUST00000035390.7 alpha-2-glycoprotein 1, zinc (from RefSeq NM_013478.2) ENSMUST00000035390.1 ENSMUST00000035390.2 ENSMUST00000035390.3 ENSMUST00000035390.4 ENSMUST00000035390.5 ENSMUST00000035390.6 NM_013478 Q64726 Q9DBB7 ZA2G_MOUSE uc009aeh.1 uc009aeh.2 uc009aeh.3 uc009aeh.4 uc009aeh.5 Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. Interacts with PIP. Secreted. Belongs to the MHC class I family. detection of chemical stimulus involved in sensory perception of bitter taste positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent extracellular region extracellular space plasma membrane immune response cell adhesion external side of plasma membrane regulation of multicellular organism growth uc009aeh.1 uc009aeh.2 uc009aeh.3 uc009aeh.4 uc009aeh.5 
ENSMUST00000035395.14 Anapc15 ENSMUST00000035395.14 anaphase promoting complex C subunit 15, transcript variant 1 (from RefSeq NM_001291348.1) 3200002M19Rik Anapc15 ENSMUST00000035395.1 ENSMUST00000035395.10 ENSMUST00000035395.11 ENSMUST00000035395.12 ENSMUST00000035395.13 ENSMUST00000035395.2 ENSMUST00000035395.3 ENSMUST00000035395.4 ENSMUST00000035395.5 ENSMUST00000035395.6 ENSMUST00000035395.7 ENSMUST00000035395.8 ENSMUST00000035395.9 H3BIU1 H3BIU1_MOUSE NM_001291348 uc009ips.1 uc009ips.2 uc009ips.3 uc009ips.4 Belongs to the APC15 family. anaphase-promoting complex regulation of mitotic cell cycle spindle assembly checkpoint uc009ips.1 uc009ips.2 uc009ips.3 uc009ips.4 
ENSMUST00000035427.11 Snapc4 ENSMUST00000035427.11 small nuclear RNA activating complex, polypeptide 4, transcript variant 1 (from RefSeq NM_172339.5) ENSMUST00000035427.1 ENSMUST00000035427.10 ENSMUST00000035427.2 ENSMUST00000035427.3 ENSMUST00000035427.4 ENSMUST00000035427.5 ENSMUST00000035427.6 ENSMUST00000035427.7 ENSMUST00000035427.8 ENSMUST00000035427.9 NM_172339 Q6PGG7 Q80UG9 Q810L1 Q8BP86 SNPC4_MOUSE Snapc4 uc008iuv.1 uc008iuv.2 uc008iuv.3 uc008iuv.4 Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity). Part of the SNAPc composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC4 interacts with SNAPC1, SNAPC2, SNAPC5, BRF2 and TBP (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q8BP86-1; Sequence=Displayed; Name=2 ; IsoId=Q8BP86-2; Sequence=VSP_051857; Name=3 ; IsoId=Q8BP86-3; Sequence=VSP_051855, VSP_051857; DNA binding nucleus snRNA-activating protein complex snRNA transcription from RNA polymerase II promoter snRNA transcription from RNA polymerase III promoter uc008iuv.1 uc008iuv.2 uc008iuv.3 uc008iuv.4 
ENSMUST00000035430.4 Dars2 ENSMUST00000035430.4 aspartyl-tRNA synthetase 2 (mitochondrial) (from RefSeq NM_172644.4) ENSMUST00000035430.1 ENSMUST00000035430.2 ENSMUST00000035430.3 NM_172644 Q5FWV4 Q8BIP0 SYDM_MOUSE uc007dey.1 uc007dey.2 uc007dey.3 uc007dey.4 Catalyzes the attachment of aspartate to tRNA(Asp) in a two- step reaction: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp). Reaction=ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L- aspartyl-tRNA(Asp); Xref=Rhea:RHEA:19649, Rhea:RHEA-COMP:9660, Rhea:RHEA-COMP:9678, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78516, ChEBI:CHEBI:456215; EC=6.1.1.12; Evidence=; Homodimer. Mitochondrion matrix Mitochondrion membrane Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. nucleotide binding nucleic acid binding aminoacyl-tRNA ligase activity aspartate-tRNA ligase activity ATP binding nucleus cytoplasm mitochondrion mitochondrial matrix translation tRNA aminoacylation for protein translation ligase activity protein homodimerization activity tRNA aminoacylation aspartate-tRNA(Asn) ligase activity mitochondrial asparaginyl-tRNA aminoacylation uc007dey.1 uc007dey.2 uc007dey.3 uc007dey.4 
ENSMUST00000035462.7 Dsel ENSMUST00000035462.7 dermatan sulfate epimerase-like (from RefSeq NM_001081316.2) B2RQ79 DSEL_MOUSE ENSMUST00000035462.1 ENSMUST00000035462.2 ENSMUST00000035462.3 ENSMUST00000035462.4 ENSMUST00000035462.5 ENSMUST00000035462.6 NM_001081316 Q0VBN2 uc007chy.1 uc007chy.2 uc007chy.3 Membrane ; Multi-pass membrane protein Belongs to the dermatan-sulfate isomerase family. cellular_component sulfotransferase activity membrane integral component of membrane isomerase activity chondroitin sulfate metabolic process dermatan sulfate metabolic process chondroitin-glucuronate 5-epimerase activity uc007chy.1 uc007chy.2 uc007chy.3 
ENSMUST00000035471.9 Lama1 ENSMUST00000035471.9 laminin, alpha 1 (from RefSeq NM_008480.2) ENSMUST00000035471.1 ENSMUST00000035471.2 ENSMUST00000035471.3 ENSMUST00000035471.4 ENSMUST00000035471.5 ENSMUST00000035471.6 ENSMUST00000035471.7 ENSMUST00000035471.8 F8VQ40 LAMA1_MOUSE Lama Lama-1 NM_008480 P19137 uc008dkh.1 uc008dkh.2 uc008dkh.3 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin). P19137; O18738: DAG1; Xeno; NbExp=2; IntAct=EBI-7176628, EBI-8522926; Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. Domains VI, IV and G are globular. Tyrosine phosphorylated by PKDCC/VLK. morphogenesis of an epithelial sheet receptor binding extracellular matrix structural constituent protein binding extracellular region basement membrane laminin-1 complex laminin-3 complex extracellular space cell-cell junction protein phosphorylation cell adhesion cell surface receptor signaling pathway axon guidance protein C-terminus binding animal organ morphogenesis tissue development membrane regulation of cell adhesion regulation of cell migration extracellular matrix neuron projection development camera-type eye development glycosphingolipid binding laminin complex establishment of epithelial cell apical/basal polarity regulation of embryonic development blood vessel morphogenesis retina development in camera-type eye epithelial tube branching involved in lung morphogenesis branching involved in salivary gland morphogenesis retinal blood vessel morphogenesis uc008dkh.1 uc008dkh.2 uc008dkh.3 
ENSMUST00000035481.5 Chchd5 ENSMUST00000035481.5 coiled-coil-helix-coiled-coil-helix domain containing 5 (from RefSeq NM_025395.3) CHCH5_MOUSE ENSMUST00000035481.1 ENSMUST00000035481.2 ENSMUST00000035481.3 ENSMUST00000035481.4 NM_025395 Q9CQP3 uc008mhg.1 uc008mhg.2 uc008mhg.3 uc008mhg.4 uc008mhg.5 Monomer. Mitochondrion intermembrane space molecular_function mitochondrion mitochondrial intermembrane space uc008mhg.1 uc008mhg.2 uc008mhg.3 uc008mhg.4 uc008mhg.5 
ENSMUST00000035488.3 Cyp2c38 ENSMUST00000035488.3 cytochrome P450, family 2, subfamily c, polypeptide 38, transcript variant 1 (from RefSeq NM_010002.4) B2RWV4 CP238_MOUSE Cyp2c38 ENSMUST00000035488.1 ENSMUST00000035488.2 F8VPK7 NM_010002 P56655 uc008hka.1 uc008hka.2 A cytochrome P450 monooxygenase that primarily catalyzes the epoxidation of 11,12 double bond of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) forming 11,12-epoxyeicosatrienoic acid (11,12-EET) regioisomer. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase). Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51480, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76625; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51481; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Lipid metabolism; arachidonate metabolism. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Liver, brain, kidney, and intestine, with trace amounts in lung and heart. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity retinoic acid 4-hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding organelle membrane caffeine oxidase activity exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity estrogen 16-alpha-hydroxylase activity uc008hka.1 uc008hka.2 
ENSMUST00000035495.15 Fanca ENSMUST00000035495.15 Fanconi anemia, complementation group A (from RefSeq NM_016925.4) E9QKQ4 ENSMUST00000035495.1 ENSMUST00000035495.10 ENSMUST00000035495.11 ENSMUST00000035495.12 ENSMUST00000035495.13 ENSMUST00000035495.14 ENSMUST00000035495.2 ENSMUST00000035495.3 ENSMUST00000035495.4 ENSMUST00000035495.5 ENSMUST00000035495.6 ENSMUST00000035495.7 ENSMUST00000035495.8 ENSMUST00000035495.9 FANCA_MOUSE NM_016925 Q9ESU9 Q9ESV3 Q9ET44 Q9JL64 Q9JL65 Q9JL66 Q9JL67 Q9JL68 Q9JL69 Q9JL70 uc009nve.1 uc009nve.2 uc009nve.3 uc009nve.4 DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity). Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM (By similarity). In complex with FANCF, FANCG and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins (By similarity). The complex with FANCC and FANCG may also include EIF2AK2 and HSP70. Interacts with FAAP20; interaction is direct (By similarity). Nucleus Cytoplasm Note=The major form is nuclear. The minor form is cytoplasmic. Mainly expressed in testis and lymphoid tissues like thymus, lymph nodes, and spleen, and at lower levels in kidney and ovary. Phosphorylated primarily on serine residues. Phosphorylation is required for the formation of the nuclear complex (By similarity). nucleus cytoplasm DNA repair cellular response to DNA damage stimulus male meiosis male gonad development female gonad development interstrand cross-link repair regulation of cell proliferation Fanconi anaemia nuclear complex regulation of regulatory T cell differentiation regulation of inflammatory response regulation of sequence-specific DNA binding transcription factor activity regulation of CD40 signaling pathway uc009nve.1 uc009nve.2 uc009nve.3 uc009nve.4 
ENSMUST00000035497.5 Oscp1 ENSMUST00000035497.5 organic solute carrier partner 1, transcript variant 1 (from RefSeq NM_172701.3) ENSMUST00000035497.1 ENSMUST00000035497.2 ENSMUST00000035497.3 ENSMUST00000035497.4 NM_172701 OSCP1_MOUSE Q8BHQ7 Q8BHW2 uc008ush.1 uc008ush.2 uc008ush.3 May be involved in drug clearance in the placenta. Basal cell membrane Predominantly expressed in testis. Sequence=BAC36814.1; Type=Frameshift; Evidence=; cytoplasm plasma membrane basal plasma membrane membrane transmembrane transporter activity drug transmembrane export uc008ush.1 uc008ush.2 uc008ush.3 
ENSMUST00000035499.5 Igdcc4 ENSMUST00000035499.5 immunoglobulin superfamily, DCC subclass, member 4, transcript variant 3 (from RefSeq NR_185285.1) Ddm36 ENSMUST00000035499.1 ENSMUST00000035499.2 ENSMUST00000035499.3 ENSMUST00000035499.4 IGDC4_MOUSE Kiaa1628 NR_185285 Nope Q80TB0 Q9EQS8 Q9EQS9 Q9JLI1 uc009qcu.1 uc009qcu.2 uc009qcu.3 uc009qcu.4 Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Ddm36; IsoId=Q9EQS9-1; Sequence=Displayed; Name=2; Synonyms=Ddm36e; IsoId=Q9EQS9-2; Sequence=VSP_028048; Name=3; IsoId=Q9EQS9-3; Sequence=VSP_028047; Expressed in skeletal muscle, heart and brain. Brain expression is hippocampus-specific. Expressed from 9.5 dpc. Expression is observed in the developing embryo, especially in the notochord, in developing skeletal muscles, and later in the ventricular zone of the nervous system. Belongs to the immunoglobulin superfamily. DCC family. molecular_function plasma membrane integral component of plasma membrane biological_process membrane integral component of membrane uc009qcu.1 uc009qcu.2 uc009qcu.3 uc009qcu.4 
ENSMUST00000035515.5 Abcb5 ENSMUST00000035515.5 ATP-binding cassette, sub-family B member 5 (from RefSeq NM_029961.2) ABCB5_MOUSE Abcb5 B5X0E4 ENSMUST00000035515.1 ENSMUST00000035515.2 ENSMUST00000035515.3 ENSMUST00000035515.4 NM_029961 W5QLL5 uc007pij.1 uc007pij.2 uc007pij.3 Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (By similarity). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (PubMed:25030174). Reaction=ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate; Xref=Rhea:RHEA:33147, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:64677, ChEBI:CHEBI:456216; EC=7.6.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33148; Evidence=; Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B5X0E4-1; Sequence=Displayed; Name=2; IsoId=B5X0E4-2; Sequence=VSP_056757; In developing eye, expressed in basal limbal epithelium but not in central cornea. Acts as a marker of limbal stem cells. Defects in corneal development. While eyes contain all anterior and posterior segment components, corneas show developmental abnormalities characterized by decreased cellularity of the apical epithelial layer and disorganized basal and wing cell layers. Defects are due to depletion of quiescent limbal stem cells, leading to enhanced proliferation and apoptosis, and resulting in defective corneal differentiation and wound healing. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. nucleotide binding ATP binding plasma membrane integral component of plasma membrane efflux transmembrane transporter activity membrane integral component of membrane ATPase activity cell differentiation regulation of membrane potential ATPase activity, coupled to transmembrane movement of substances compound eye corneal lens development transmembrane transport uc007pij.1 uc007pij.2 uc007pij.3 
ENSMUST00000035521.11 Rsph6a ENSMUST00000035521.11 radial spoke head 6 homolog A (Chlamydomonas), transcript variant 1 (from RefSeq NM_031255.3) ENSMUST00000035521.1 ENSMUST00000035521.10 ENSMUST00000035521.2 ENSMUST00000035521.3 ENSMUST00000035521.4 ENSMUST00000035521.5 ENSMUST00000035521.6 ENSMUST00000035521.7 ENSMUST00000035521.8 ENSMUST00000035521.9 NM_031255 Q8CDR2 Q99MM8 Q99MM9 RSH6A_MOUSE Rshl1 Rsph6a uc009fkj.1 uc009fkj.2 uc009fkj.3 uc009fkj.4 Functions as part of radial spoke complexes in the axoneme of sperm flagella that play an important part in motility (PubMed:36417862). The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum (PubMed:36417862, PubMed:30185526, PubMed:30239614). Component of the axonemal radial spoke 1 (RS1) and 2 (RS2) complexes, at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the RS1 complex-specific anchor protein IQUB (PubMed:36417862, PubMed:34871179). Interacts with RSPH1 (PubMed:30185526, PubMed:34871179). Interacts with RSPH3B (PubMed:34871179). Interacts with RSPH4A (PubMed:30185526). Interacts with RSPH9 (PubMed:30185526, PubMed:34871179). Interacts with RSPH10B (PubMed:30185526). Cytoplasm, cytoskeleton, flagellum axoneme Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CDR2-1; Sequence=Displayed; Name=2; IsoId=Q8CDR2-2; Sequence=VSP_060558; Expressed in sperm and testis (at protein level). First detected during the haploid phase of spermatogenesis when secondary spermatocytes begin to appear at about postnatal day 18 (PubMed:30185526). Expression is maintained in mature sperm (PubMed:30239614). Phosphorylated by PKA. Phosphorylation increases in capacitated sperm. Male mutant mice are infertile. Mutant spermatozoa exhibit shorter tails, misshapen heads and immotility. Manchette removal is impaired. Belongs to the flagellar radial spoke RSP4/6 family. radial spoke molecular_function cilium biological_process cilium assembly cilium movement involved in cell motility uc009fkj.1 uc009fkj.2 uc009fkj.3 uc009fkj.4 
ENSMUST00000035540.9 Phf2 ENSMUST00000035540.9 PHD finger protein 2 (from RefSeq NM_011078.3) ENSMUST00000035540.1 ENSMUST00000035540.2 ENSMUST00000035540.3 ENSMUST00000035540.4 ENSMUST00000035540.5 ENSMUST00000035540.6 ENSMUST00000035540.7 ENSMUST00000035540.8 Kiaa0662 NM_011078 PHF2_MOUSE Q6A023 Q80WA8 Q9WTU0 uc007qin.1 uc007qin.2 uc007qin.3 uc007qin.4 Lysine demethylase that demethylates both histones and non- histone proteins (PubMed:22921934). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity). Involved in the activation of toll-like receptor 4 (TLR4)- target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (PubMed:22921934). Reaction=2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate; Xref=Rhea:RHEA:60192, Rhea:RHEA-COMP:15541, Rhea:RHEA- COMP:15542, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60193; Evidence=; Enzymatically inactive by itself, and become active following phosphorylation by PKA. Component of the PHF2-ARID5B complex, at least composed of PHF2 and ARID5B. Interacts with HNF4A and NR1H4 (By similarity). Interacts with RELA (PubMed:22921934). Nucleus, nucleolus Chromosome, centromere, kinetochore The PHD-type zinc finger mediates the binding to H3K4me2 and H3K4me3. Phosphorylated by PKA on specific serine residues, leading to the formation of an active lysine demethylase complex. Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. In contrast to the related histone demethylases JHDM1D and PHF8, the conserved active His in position 321 is replaced by a Tyr. However, the presence of a Tyr residue neither affects binding to the catalytic iron nor abolishes demethylase activity. chromosome, centromeric region kinetochore condensed chromosome kinetochore transcription coactivator activity iron ion binding nucleus chromosome nucleolus chromatin organization protein demethylation zinc ion binding oxidoreductase activity histone demethylase activity (H3-K9 specific) histone H3-K9 demethylation methylated histone binding metal ion binding dioxygenase activity oxidation-reduction process negative regulation of chromatin silencing at rDNA uc007qin.1 uc007qin.2 uc007qin.3 uc007qin.4 
ENSMUST00000035548.16 Alpk2 ENSMUST00000035548.16 alpha-kinase 2 (from RefSeq NM_001037294.1) ALPK2_MOUSE Alpk2 E9QL35 ENSMUST00000035548.1 ENSMUST00000035548.10 ENSMUST00000035548.11 ENSMUST00000035548.12 ENSMUST00000035548.13 ENSMUST00000035548.14 ENSMUST00000035548.15 ENSMUST00000035548.2 ENSMUST00000035548.3 ENSMUST00000035548.4 ENSMUST00000035548.5 ENSMUST00000035548.6 ENSMUST00000035548.7 ENSMUST00000035548.8 ENSMUST00000035548.9 Hak NM_001037294 Q91ZB0 uc008feu.1 uc008feu.2 uc008feu.3 uc008feu.4 uc008feu.5 uc008feu.6 uc008feu.7 Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Basolateral cell membrane Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. heart morphogenesis negative regulation of Wnt signaling pathway involved in heart development protein serine/threonine kinase activity ATP binding protein phosphorylation regulation of gene expression kinase activity phosphorylation basolateral plasma membrane transferase activity establishment of cell polarity regulation of apoptotic process cardiac muscle cell development epicardium morphogenesis uc008feu.1 uc008feu.2 uc008feu.3 uc008feu.4 uc008feu.5 uc008feu.6 uc008feu.7 
ENSMUST00000035560.9 Acbd6 ENSMUST00000035560.9 acyl-Coenzyme A binding domain containing 6, transcript variant 1 (from RefSeq NM_028250.3) ACBD6_MOUSE ENSMUST00000035560.1 ENSMUST00000035560.2 ENSMUST00000035560.3 ENSMUST00000035560.4 ENSMUST00000035560.5 ENSMUST00000035560.6 ENSMUST00000035560.7 ENSMUST00000035560.8 NM_028250 Q3TMN7 Q9D061 Q9DCU4 uc011wtw.1 uc011wtw.2 uc011wtw.3 Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids (By similarity). Monomer. Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D061-1; Sequence=Displayed; Name=2; IsoId=Q9D061-2; Sequence=VSP_018003, VSP_018004; Name=3; IsoId=Q9D061-3; Sequence=VSP_018002, VSP_018005; fatty-acyl-CoA binding molecular_function cytoplasm biological_process lipid binding uc011wtw.1 uc011wtw.2 uc011wtw.3 
ENSMUST00000035565.5 Pkd1 ENSMUST00000035565.5 polycystin 1, transient receptor potential channel interacting (from RefSeq NM_013630.3) E9QJR6 ENSMUST00000035565.1 ENSMUST00000035565.2 ENSMUST00000035565.3 ENSMUST00000035565.4 NM_013630 O08852 PKD1_MOUSE Pkd1 uc008awv.1 uc008awv.2 uc008awv.3 Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel activity (By similarity). Involved in renal tubulogenesis (PubMed:24939912). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735). Acts as a regulator of cilium length, together with PKD2 (PubMed:20096584). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow- induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Likely to be involved with polycystin-1-interacting protein 1 in the detection, sequestration and exocytosis of senescent mitochondria (By similarity). Component of the heterotetrameric polycystin channel complex with PKD2; the tetramer contains one PKD1 chain and three PKD2 chains (By similarity). Interacts with PKD2; the interaction is required for ciliary localization (PubMed:25405894). Interacts with PKD2L1 (PubMed:15548533). Interacts with PRKX; involved in differentiation and controlled morphogenesis of the kidney. Interacts (via extracellular domain) with WNT3A, WNT4 and WNT9B (By similarity). Interacts with WNT5A, DVL1 and DVL2 (PubMed:27214281). Interacts with NPHP1 (via SH3 domain) (PubMed:20856870). Interacts with BBS1, BBS4, BBS5 and TTC8. Interacts with RGS7 (By similarity). Interacts (via C-terminal domain) with RABEP1; the interaction connects PKD1:PKD2 to GGA1 and ARL3 that mediate the ciliary targeting (PubMed:25405894). Interacts (via the PKD repeats in the N-terminal extracellular region) with polycystin-1- interacting protein 1; the interaction is not dependent on N- glycosylation of either protein (By similarity). O08852; Q13563-1: PKD2; Xeno; NbExp=2; IntAct=EBI-6666305, EBI-9837017; Cell membrane ; Multi-pass membrane protein Cell projection, cilium doplasmic reticulum Golgi apparatus Vesicle Secreted, extracellular exosome Note=PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autocatalytic cleavage at the GPS domain (PubMed:12514735, PubMed:25405894). PKD1:PKD2 interaction is required to reach the Golgi apparatus from endoplasmic reticulum and then traffic to the cilia (PubMed:25405894). Ciliary localization of PKD1 requires BBS1 and ARL6/BBS3 (PubMed:24939912). Cell surface localization requires GANAB (By similarity). Detected on migrasomes and on extracellular exosomes in urine (By similarity). The LDL-receptor class A domain is atypical; the potential calcium-binding site is missing. After synthesis, undergoes autoproteolytic cleavage between Leu- 3040 and Thr-3041 in the GPS domain (PubMed:25405894). Cleavage at the GPS domain occurs through a cis-autoproteolytic mechanism involving an ester-intermediate via N-O acyl rearrangement (By similarity). This process takes place in the early secretory pathway, depends on initial N-glycosylation, and requires the REJ domain (By similarity). PKD1 is ubiquitously and incompletely cleaved in wild-type mice, so that uncleaved and cleaved PKD1 molecules coexist. The differential patterns of cleavage during embryonic development, as well as in adult mice, suggest different functions of uncleaved and cleaved molecules (PubMed:18003909). N-glycosylated. Knockin mice expressing non-cleavable PKD1 show a hypomorphic phenotype. They are viable, show rapid cystic dilation in renal collecting duct and distal convoluted tubule, but not in the proximal portion of the nephron, during the postnatal period, and die with severe uremia, mostly at 3 weeks of age. Additionally, they show dilation of the common bile duct and intrahepatic biliary ducts, but develop a normal pancreas within their life span. Belongs to the polycystin family. Name=Functional Glycomics Gateway - Glycan Binding; Note=Polycystin-1; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_149"; cartilage condensation blood vessel development in utero embryonic development kidney development liver development embryonic placenta development polycystin complex calcium channel activity protein binding nucleus cytoplasm endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane cilium protein export from nucleus nitrogen compound metabolic process calcium ion transport cell cycle arrest positive regulation of cytosolic calcium ion concentration JAK-STAT cascade heart development cell surface membrane integral component of membrane Wnt signaling pathway basolateral plasma membrane lateral plasma membrane peptidyl-serine phosphorylation protein kinase binding protein domain specific binding spinal cord development neural tube development establishment of cell polarity regulation of cell adhesion carbohydrate binding motile cilium positive regulation of protein binding response to fluid shear stress cation channel complex calcium channel complex lymph vessel morphogenesis Wnt-activated receptor activity cytoplasmic sequestering of transcription factor cell projection skin development ion channel binding positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription from RNA polymerase II promoter digestive tract development branching morphogenesis of an epithelial tube genitalia development detection of mechanical stimulus cartilage development protein heterotetramerization regulation of mitotic spindle organization lung epithelium development placenta blood vessel development regulation of proteasomal protein catabolic process extracellular exosome calcium ion transmembrane transport mesonephric tubule development mesonephric duct development metanephric collecting duct development metanephric ascending thin limb development metanephric proximal tubule development metanephric distal tubule morphogenesis cell-cell adhesion cell-cell signaling by wnt regulation of G1/S transition of mitotic cell cycle uc008awv.1 uc008awv.2 uc008awv.3 
ENSMUST00000035571.10 Cyp3a59 ENSMUST00000035571.10 cytochrome P450, family 3, subfamily a, polypeptide 59 (from RefSeq NM_001105160.1) Cyp3a59 D3Z2W7 D3Z2W7_MOUSE ENSMUST00000035571.1 ENSMUST00000035571.2 ENSMUST00000035571.3 ENSMUST00000035571.4 ENSMUST00000035571.5 ENSMUST00000035571.6 ENSMUST00000035571.7 ENSMUST00000035571.8 ENSMUST00000035571.9 NM_001105160 uc012egy.1 uc012egy.2 uc012egy.3 uc012egy.4 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence= Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane eripheral membrane protein Membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cellular_component steroid metabolic process testosterone 16-alpha-hydroxylase activity steroid hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding metal ion binding testosterone 6-beta-hydroxylase activity oxidation-reduction process oxidative demethylation uc012egy.1 uc012egy.2 uc012egy.3 uc012egy.4 
ENSMUST00000035577.7 Cpa6 ENSMUST00000035577.7 carboxypeptidase A6, transcript variant 1 (from RefSeq NM_177834.5) CBPA6_MOUSE ENSMUST00000035577.1 ENSMUST00000035577.2 ENSMUST00000035577.3 ENSMUST00000035577.4 ENSMUST00000035577.5 ENSMUST00000035577.6 NM_177834 Q5U901 Q8BVD0 uc007ahq.1 uc007ahq.2 uc007ahq.3 uc007ahq.4 This gene encodes a protein that belongs to the metallocarboxypeptidase family of proteins that catalyze the release of a C-terminal amino acid from the target protein. The encoded preproprotein undergoes proteolytic cleavage to yield the mature form which is thought to play a role in cell migration. In humans, this protein regulates neuropeptides in the brain and mutations in this gene are associated with a recessive familial form of febrile seizures and with temporal lobe epilepsy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]. May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II. Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5U901-1; Sequence=Displayed; Name=2; IsoId=Q5U901-2; Sequence=VSP_017081; In brain, highly expressed in the olfactory bulb with lower levels in other regions including cerebral cortex, hippocampus, hypothalamus, striatum and medulla. Within the olfactory bulb, highest levels occur in the mitral and granular layers with lower levels in the internal and external plexiform layers. Moderate levels are found in the epididymis with low levels in colon and spleen. Not detected in adrenal, liver, lung, ovary or testis. At embryonic day 14.5, enriched in eye, ear, osteoblasts, stomach, skin, dorsal root ganglia and throughout the CNS. Belongs to the peptidase M14 family. carboxypeptidase activity metallocarboxypeptidase activity extracellular region extracellular space proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding uc007ahq.1 uc007ahq.2 uc007ahq.3 uc007ahq.4 
ENSMUST00000035597.10 Sppl2b ENSMUST00000035597.10 signal peptide peptidase like 2B, transcript variant 1 (from RefSeq NM_175195.3) ENSMUST00000035597.1 ENSMUST00000035597.2 ENSMUST00000035597.3 ENSMUST00000035597.4 ENSMUST00000035597.5 ENSMUST00000035597.6 ENSMUST00000035597.7 ENSMUST00000035597.8 ENSMUST00000035597.9 NM_175195 Q3TD49 Q3TLQ8 Q3UG60 Q80VZ6 SPP2B_MOUSE Sppl2b uc007gfc.1 uc007gfc.2 Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. Monomer. Homodimer. Interacts with ITM2B and TNF. Cell membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein ; Lumenal side Note=targeted through the entire secretory pathway to endosomes/lysosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TD49-1; Sequence=Displayed; Name=2; IsoId=Q3TD49-2; Sequence=VSP_018571, VSP_018572; The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP. Glycosylated. Belongs to the peptidase A22B family. Golgi membrane aspartic-type endopeptidase activity nucleoplasm lysosome lysosomal membrane endosome Golgi apparatus centrosome plasma membrane proteolysis membrane protein ectodomain proteolysis peptidase activity endosome membrane actin cytoskeleton membrane integral component of membrane hydrolase activity Golgi-associated vesicle membrane membrane protein intracellular domain proteolysis membrane protein proteolysis aspartic endopeptidase activity, intramembrane cleaving protein homodimerization activity regulation of immune response integral component of cytoplasmic side of endoplasmic reticulum membrane integral component of lumenal side of endoplasmic reticulum membrane uc007gfc.1 uc007gfc.2 
ENSMUST00000035606.10 Ascc3 ENSMUST00000035606.10 activating signal cointegrator 1 complex subunit 3 (from RefSeq NM_198007.2) ASCC3_MOUSE E9PZJ8 ENSMUST00000035606.1 ENSMUST00000035606.2 ENSMUST00000035606.3 ENSMUST00000035606.4 ENSMUST00000035606.5 ENSMUST00000035606.6 ENSMUST00000035606.7 ENSMUST00000035606.8 ENSMUST00000035606.9 NM_198007 Q6PB36 Q8C1G1 Q8C707 Q8K292 uc007fak.1 uc007fak.2 uc007fak.3 uc007fak.4 ATPase involved both in DNA repair and rescue of stalled ribosomes. 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Identified in the ASCC complex that contains ASCC1, ASCC2 and ASCC3. Functions as a scaffolding subunit that interacts directly with both ASCC1 and ASCC2. Interacts directly with ALKBH3, and thereby recruits ALKBH3 to the ASCC complex. Part of the ASC-1/TRIP4 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3. Part of the RQT (ribosome quality control trigger) complex, that contains ASCC2, ASCC3 and TRIP4. Associates with ribosomes; recruited to collided ribosomes. Interacts with ZCCHC4. Interacts with ZNF598. Interacts with RPS3. Nucleus Nucleus speckle Cytoplasm, cytosol Note=Colocalizes with ALKBH3 and ASCC2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9PZJ8-1; Sequence=Displayed; Name=2; IsoId=E9PZJ8-2; Sequence=VSP_042999; Belongs to the helicase family. Sequence=AAH32189.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding nucleic acid binding DNA helicase activity helicase activity ATP binding nucleus cytosol DNA repair DNA dealkylation involved in DNA repair cellular response to DNA damage stimulus cell proliferation nuclear speck hydrolase activity DNA duplex unwinding 3'-5' DNA helicase activity activating signal cointegrator 1 complex uc007fak.1 uc007fak.2 uc007fak.3 uc007fak.4 
ENSMUST00000035608.10 Olig2 ENSMUST00000035608.10 oligodendrocyte transcription factor 2 (from RefSeq NM_016967.2) ENSMUST00000035608.1 ENSMUST00000035608.2 ENSMUST00000035608.3 ENSMUST00000035608.4 ENSMUST00000035608.5 ENSMUST00000035608.6 ENSMUST00000035608.7 ENSMUST00000035608.8 ENSMUST00000035608.9 NM_016967 OLIG2_MOUSE Q9EQW6 Q9JKN4 uc007zxe.1 uc007zxe.2 uc007zxe.3 Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain (PubMed:11955448, PubMed:12121626, PubMed:16908628). Functions together with ZNF488 to promote oligodendrocyte differentiation (PubMed:16908628). Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube (PubMed:11955448, PubMed:12121626). Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (PubMed:11955448, PubMed:12121626). Interacts with NKX2-2 (PubMed:14573534). Interacts with ZNF488 (PubMed:16908628). Q9EQW6; P41136: Id2; NbExp=4; IntAct=EBI-1213740, EBI-309167; Q9EQW6; P41139: Id4; NbExp=5; IntAct=EBI-1213740, EBI-1213725; Nucleus. Cytoplasm. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. Expressed specifically in the brain. Expressed in the ventral spinal cord as early as 9.5 dpc. Expression becomes progressively restricted to a narrow zone within the ventral neuroepithelium of the spinal cord. In the 14.5 dpc spinal cord, expressed in the oligodendrocyte progenitors of the ventral ventricular zone, but not dorsal root ganglia Schwann cells. Also expressed scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. In the brain, from 10.5 through 14.5 dpc, expressed in numerous cells in the ventricular and subventricular zones of the lateral and medial ganglionic eminences, suggesting that expression might not be limited to the oligodendrocytic lineage. By 15.5 dpc, dispersed throughout the gray matter, with little or no residual expression in the ventricular zone. In the postnatal brain, present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Expressed in the 13.5 and 14.5 dpc retina and in the olfactory epithelium from 11.5 dpc onward. By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain. The bHLH is essential for interaction with NKX2-2. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm regulation of transcription, DNA-templated multicellular organism development nervous system development spinal cord motor neuron differentiation spinal cord oligodendrocyte cell differentiation spinal cord oligodendrocyte cell fate specification oligodendrocyte cell fate specification thalamus development neuron differentiation myelination protein homodimerization activity negative regulation of neuron differentiation protein dimerization activity neuron fate commitment oligodendrocyte differentiation positive regulation of oligodendrocyte differentiation HMG box domain binding uc007zxe.1 uc007zxe.2 uc007zxe.3 
ENSMUST00000035612.7 Ccar2 ENSMUST00000035612.7 cell cycle activator and apoptosis regulator 2 (from RefSeq NM_146055.3) CCAR2_MOUSE ENSMUST00000035612.1 ENSMUST00000035612.2 ENSMUST00000035612.3 ENSMUST00000035612.4 ENSMUST00000035612.5 ENSMUST00000035612.6 NM_146055 Q6PIB1 Q8BWR5 Q8C0F0 Q8R3G6 Q8VDP4 uc007unf.1 uc007unf.2 uc007unf.3 uc007unf.4 Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (By similarity). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (By similarity). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand- dependent transcriptional activation by nuclear hormone receptors (By similarity). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (By similarity). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (By similarity). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (By similarity). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (By similarity). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (By similarity). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (By similarity). Component of the DBIRD complex (By similarity). Interacts with ZNF326/ZIRD; the interaction is direct (By similarity). Interacts (via N-terminus) with SIRT1, which inhibits the deacetylation of substrates (PubMed:21030595). Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1 (PubMed:19218236). Component of a nuclear receptor-mediated transcription complex composed of at least ZNF335, CCAR2 and EMSY; the complex stimulates the transcription of nuclear receptor target genes such as SOX9 and HOXA1 (By similarity). Within the complex interacts with EMSY and interacts with ZNF335 (via C-terminus) (By similarity). Components of this complex may associate with components of a histone methylation complex to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5 (By similarity). Within this complex, interacts with ASH2L (By similarity). Interacts with NR1D1 (PubMed:23398316). Interacts (via N-terminus) with ESR1 and ESR2 (By similarity). Interacts (via N-terminus) with HDAC3 (via C-terminus) (PubMed:21030595). Interacts with HDAC1 and MED2F (PubMed:21030595). Interacts with MCC (By similarity). Interacts (via N-terminus) with NR1H2 and NR1H3 in a ligand-independent manner (By similarity). Interacts with CSNK2A1 (By similarity). Interacts (via N-terminus) with p53/TP53 (PubMed:25732823). Interacts (via N-terminus) with BRCA1 (via the BRCT domains) (By similarity). Interacts (via N-terminus) with CHEK2 (via protein kinase domain) (By similarity). Interacts with PSEM3 (By similarity). Interacts (via N-terminus) with PSIA3 and SENP1 (By similarity). The sumoylated form shows a preferential interaction with SIRT1 as compared to its unmodified form (By similarity). Nucleus Cytoplasm Cytoplasm, cytoskeleton, spindle Note=Recruited to chromatin, post-UV irradiation. Sequestered to the cytoplasm in the presence of MCC. Translocated to the cytoplasm during UV-induced apoptosis. Acetylation at Lys-112 and Lys-215 by KAT8 prevents inhibitory binding to SIRT1 and increases its deacetylase activity. Genotoxic stress induces its sumoylation and sumoylation promotes the SIRT1-CCAR2 interaction which in turn inhibits SIRT1-mediated deacetylation of p53/TP53. Sumoylation leads to transcriptional activation of p53/TP53 by sequestering SIRT1 from p53/TP53. Desumoylated by SENP1. Mice mimic a fasted state and therefore, display an increased production of glucose. Display elevated levels of PCK1 and are glucose-intolerant in both a normal and a high-fat diet (PubMed:24415752). Mice develop more tumors including lymphomas, liver tumors, lung tumors (PubMed:25732823). Sequence=BAC27420.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC34139.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nuclear chromatin RNA polymerase II core binding enzyme inhibitor activity protein binding nucleus nucleoplasm cytoplasm mitochondrial matrix regulation of transcription, DNA-templated mRNA processing apoptotic process cellular response to DNA damage stimulus cell cycle RNA splicing response to UV Wnt signaling pathway enzyme binding negative regulation of cell growth ligand-dependent nuclear receptor transcription coactivator activity regulation of protein stability negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of DNA-templated transcription, elongation regulation of circadian rhythm positive regulation of apoptotic process negative regulation of catalytic activity mitochondrial fragmentation involved in apoptotic process DBIRD complex negative regulation of transcription, DNA-templated rhythmic process positive regulation of canonical Wnt signaling pathway regulation of protein deacetylation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of nucleic acid-templated transcription positive regulation of DNA damage checkpoint uc007unf.1 uc007unf.2 uc007unf.3 uc007unf.4 
ENSMUST00000035622.8 Wdr93 ENSMUST00000035622.8 WD repeat domain 93, transcript variant 5 (from RefSeq NM_001421522.1) B9EKH5 ENSMUST00000035622.1 ENSMUST00000035622.2 ENSMUST00000035622.3 ENSMUST00000035622.4 ENSMUST00000035622.5 ENSMUST00000035622.6 ENSMUST00000035622.7 NM_001421522 Q402B2 WDR93_MOUSE uc009hza.1 uc009hza.2 Testis-specific. Expressed in spermatogonia, spermatocytes and spermatids. mitochondrial respiratory chain complex I NADH dehydrogenase (ubiquinone) activity biological_process oxidoreductase activity, acting on NAD(P)H electron transport chain uc009hza.1 uc009hza.2 
ENSMUST00000035625.7 Cyp7b1 ENSMUST00000035625.7 cytochrome P450, family 7, subfamily b, polypeptide 1, transcript variant 1 (from RefSeq NM_007825.5) CP7B1_MOUSE Cyp7b1 ENSMUST00000035625.1 ENSMUST00000035625.2 ENSMUST00000035625.3 ENSMUST00000035625.4 ENSMUST00000035625.5 ENSMUST00000035625.6 NM_007825 Q60991 Q9CZ39 uc008orm.1 uc008orm.2 uc008orm.3 A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids (PubMed:9295351, PubMed:9144166, PubMed:10748047, PubMed:11067870). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position. Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy steroid 7-alpha hydroxylase (PubMed:9295351, PubMed:9144166, PubMed:10748047, PubMed:11067870). Hydroxylates oxysterols, including 25-hydroxycholesterol and (25R)-cholest-5-ene- 3beta,26-diol toward 7-alpha hydroxy derivatives, which may be transported to the liver and converted to bile acids (PubMed:9295351, PubMed:9144166, PubMed:10748047, PubMed:11067870). Via its product 7- alpha,25-dihydroxycholesterol, a ligand for the chemotactic G protein- coupled receptor GPR183/EBI2, regulates B cell migration in germinal centers of lymphoid organs, thus guiding efficient maturation of plasma B cells and overall antigen-specific humoral immune response (PubMed:22999953). 7-alpha hydroxylates neurosteroids, including 3beta- hydroxyandrost-5-en-17-one (dehydroepiandrosterone) and pregnenolone, both involved in hippocampus-associated memory and learning (PubMed:9144166). Metabolizes androstanoids toward 6- or 7-alpha hydroxy derivatives (By similarity). Reaction=25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:24308, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:37623, ChEBI:CHEBI:42977, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.29; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24309; Evidence=; Reaction=(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH-- hemoprotein reductase] = (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:19041, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76591, ChEBI:CHEBI:76592; EC=1.14.14.29; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19042; Evidence=; Reaction=(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46124, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:34310, ChEBI:CHEBI:37640, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.26; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46125; Evidence=; Reaction=(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46464, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:41633, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:86146; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46465; Evidence=; Reaction=(22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46460, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:67237, ChEBI:CHEBI:86145; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46461; Evidence=; Reaction=androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH-- hemoprotein reductase] = androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46204, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:2710, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:85810; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46205; Evidence=; Reaction=5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH-- hemoprotein reductase] = 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46200, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18329, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:85809; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46201; Evidence=; Reaction=3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH-- hemoprotein reductase] = 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46192, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:28689, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:81471; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46193; Evidence=; Reaction=3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH-- hemoprotein reductase] = 3beta,7alpha-dihydroxy-5alpha-androstan-17- one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:43896, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:85816, ChEBI:CHEBI:541975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43897; Evidence=; Reaction=O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:46196, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16581, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:81467; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46197; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Inhibited by drugs voriconazole and metyrapone. Kinetic parameters: KM=13.6 uM for 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone) ; KM=4 uM for pregnenolone ; Lipid metabolism; bile acid biosynthesis. Steroid hormone biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Microsome membrane ; Multi-pass membrane protein Highly expressed in brain structures including the corpus callosum, the anterior commissure and fornix (PubMed:8530364). The hippocampal expression is particularly prominent in the dentate gyrus (PubMed:8530364). Expressed in liver and kidney. The hepatic expression is sexually dimorphic, predominantly detected in male liver while barely detectable in females (PubMed:8530364). Expressed in lymph nodes and spleens, in both lymphoid and stromal compartments (PubMed:22999953). Higher expression is detected in fibroblastic reticular cells, a type of stromal cells in the lymph nodes (PubMed:22999953). Also expressed at high levels in the outer follicle and at the B cell-T cell boundary of splenic germinal centers (PubMed:22999953). Expressed in dendritic cells (DCs) subpopulations being most abundant in CD8-positive DCs (PubMed:22999953). Knockout mice exhibit impaired generation of plasma cells and overall deficient antigen-specific humoral immune response. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process bile acid biosynthetic process digestion memory circadian rhythm steroid metabolic process cholesterol metabolic process oxysterol 7-alpha-hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding organelle membrane negative regulation of intracellular estrogen receptor signaling pathway B cell chemotaxis cholesterol homeostasis intracellular membrane-bounded organelle metal ion binding positive regulation of epithelial cell proliferation oxidation-reduction process prostate gland epithelium morphogenesis uc008orm.1 uc008orm.2 uc008orm.3 
ENSMUST00000035626.8 4930480E11Rik ENSMUST00000035626.8 RIKEN cDNA 4930480E11 gene (from RefSeq NM_001177966.2) 4930480E11Rik ENSMUST00000035626.1 ENSMUST00000035626.2 ENSMUST00000035626.3 ENSMUST00000035626.4 ENSMUST00000035626.5 ENSMUST00000035626.6 ENSMUST00000035626.7 NM_001177966 Q0VG34 Q0VG34_MOUSE uc009tqw.1 uc009tqw.2 uc009tqw.3 uc009tqw.4 Belongs to the FAM47 family. molecular_function cellular_component biological_process uc009tqw.1 uc009tqw.2 uc009tqw.3 uc009tqw.4 
ENSMUST00000035635.10 Bmp2k ENSMUST00000035635.10 BMP2 inducible kinase, transcript variant 1 (from RefSeq NM_080708.2) BMP2K_MOUSE Bike ENSMUST00000035635.1 ENSMUST00000035635.2 ENSMUST00000035635.3 ENSMUST00000035635.4 ENSMUST00000035635.5 ENSMUST00000035635.6 ENSMUST00000035635.7 ENSMUST00000035635.8 ENSMUST00000035635.9 NM_080708 Q8C8L7 Q91Z96 uc008yfp.1 uc008yfp.2 uc008yfp.3 May be involved in osteoblast differentiation. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91Z96-1; Sequence=Displayed; Name=2; IsoId=Q91Z96-2; Sequence=VSP_008094, VSP_008095; Expressed in osteocytes and osteoblasts. Autophosphorylated. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus protein phosphorylation kinase activity phosphorylation nuclear speck transferase activity phosphatase regulator activity regulation of bone mineralization AP-2 adaptor complex binding positive regulation of Notch signaling pathway regulation of catalytic activity regulation of clathrin-dependent endocytosis uc008yfp.1 uc008yfp.2 uc008yfp.3 
ENSMUST00000035640.13 Spmip10 ENSMUST00000035640.13 sperm microtubule inner protein 10 (from RefSeq NM_026099.3) C5orf48 ENSMUST00000035640.1 ENSMUST00000035640.10 ENSMUST00000035640.11 ENSMUST00000035640.12 ENSMUST00000035640.2 ENSMUST00000035640.3 ENSMUST00000035640.4 ENSMUST00000035640.5 ENSMUST00000035640.6 ENSMUST00000035640.7 ENSMUST00000035640.8 ENSMUST00000035640.9 NM_026099 Q9D9I1 SMI10_MOUSE Tex43 uc008eyr.1 uc008eyr.2 uc008eyr.3 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme, which is required for flagellum beating. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella (By similarity). Involved in the regulation of sperm motility (PubMed:34446558). Cytoplasm, cytoskeleton, cilium axoneme Note=Localizes at the ribbon and inner junction (IJ) between A- and B-tubules of the DMTs. Expressed predominantly in the testis. No defects seen in the sperm morphology and the percentage of motile spermatozoa is comparable (PubMed:34446558). Howevwer, velocity parameters such as average path velocity, straight- line velocity, and curvilinear velocity are slightly decreased in the spermatozoa (PubMed:34446558). molecular_function cellular_component biological_process uc008eyr.1 uc008eyr.2 uc008eyr.3 
ENSMUST00000035645.13 Rusc2 ENSMUST00000035645.13 RUN and SH3 domain containing 2, transcript variant 5 (from RefSeq NM_001426154.1) ENSMUST00000035645.1 ENSMUST00000035645.10 ENSMUST00000035645.11 ENSMUST00000035645.12 ENSMUST00000035645.2 ENSMUST00000035645.3 ENSMUST00000035645.4 ENSMUST00000035645.5 ENSMUST00000035645.6 ENSMUST00000035645.7 ENSMUST00000035645.8 ENSMUST00000035645.9 NM_001426154 Q3V1Z0 Q3V1Z0_MOUSE Rusc2 uc008spm.1 uc008spm.2 uc008spm.3 uc008spm.4 uc008spm.5 Rab GTPase binding cytoplasmic vesicle uc008spm.1 uc008spm.2 uc008spm.3 uc008spm.4 uc008spm.5 
ENSMUST00000035648.6 Atg12 ENSMUST00000035648.6 autophagy related 12 (from RefSeq NM_026217.3) ATG12_MOUSE Apg12 Apg12l ENSMUST00000035648.1 ENSMUST00000035648.2 ENSMUST00000035648.3 ENSMUST00000035648.4 ENSMUST00000035648.5 NM_026217 Q3TKE5 Q9CQY1 Q9D7Y5 uc008evu.1 uc008evu.2 uc008evu.3 Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection. Forms a conjugate with ATG5 (PubMed:11266458, PubMed:12482611, PubMed:12890687, PubMed:12665549, PubMed:18768753, PubMed:19417210). The ATG12-ATG5 conjugate forms a complex with several units of ATG16L1 (PubMed:12665549). Forms an 800-kDa complex composed of ATG12-ATG5 and ATG16L2 (PubMed:22082872). Interacts with DHX58/RIG-1, IFIH1/MDA5 and MAVS/IPS-1 in monomeric form as well as in ATG12-ATG5 conjugate. The interaction with MAVS is further enhanced upon vesicular stomatitis virus (VSV) infection. Interacts with ATG3 and ATG7 (By similarity). Interacts with ATG10 (PubMed:12482611). Interacts with TECPR1 (By similarity). Interacts with SH3BGRL (By similarity). Q9CQY1; Q9CPX6: Atg3; NbExp=5; IntAct=EBI-2911788, EBI-2911810; Q9CQY1; Q99J83: Atg5; NbExp=4; IntAct=EBI-2911788, EBI-2911848; Q9CQY1; Q9WU78-1: Pdcd6ip; NbExp=3; IntAct=EBI-2911788, EBI-15788421; Cytoplasm Preautophagosomal structure membrane ; Peripheral membrane protein Note=TECPR1 recruits the ATG12- ATG5 conjugate to the autolysosomal membrane. Ubiquitous. Shares weak sequence similarity with ubiquitin family, but contains an 'ubiquitin superfold' and the C-terminal Gly is required for isopeptide linkage. Acetylated by EP300. Belongs to the ATG12 family. autophagosome assembly mitophagy protein binding cytoplasm autophagosome cytosol C-terminal protein lipidation autophagy membrane Atg8 ligase activity macromolecular complex pre-autophagosomal structure membrane Atg12-Atg5-Atg16 complex uc008evu.1 uc008evu.2 uc008evu.3 
ENSMUST00000035651.6 Lrrc17 ENSMUST00000035651.6 leucine rich repeat containing 17 (from RefSeq NM_028977.1) ENSMUST00000035651.1 ENSMUST00000035651.2 ENSMUST00000035651.3 ENSMUST00000035651.4 ENSMUST00000035651.5 LRC17_MOUSE NM_028977 Q9CXD9 uc008wor.1 uc008wor.2 uc008wor.3 uc008wor.4 uc008wor.5 Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors. Secreted, extracellular space Expressed in osteoblasts, spleen, lung and heart. Down-regulated in osteoblasts in response to pro- osteoclastogenic factors. ossification molecular_function extracellular region extracellular space extracellular matrix negative regulation of osteoclast differentiation bone marrow development osteoblast differentiation osteoblast proliferation uc008wor.1 uc008wor.2 uc008wor.3 uc008wor.4 uc008wor.5 
ENSMUST00000035661.7 Cspg4 ENSMUST00000035661.7 chondroitin sulfate proteoglycan 4 (from RefSeq NM_139001.2) An2 CSPG4_MOUSE ENSMUST00000035661.1 ENSMUST00000035661.2 ENSMUST00000035661.3 ENSMUST00000035661.4 ENSMUST00000035661.5 ENSMUST00000035661.6 G5E892 Kiaa4232 NM_139001 Ng2 Q5DTG1 Q8BPI8 Q8CE79 Q8VHY0 uc009ptm.1 uc009ptm.2 uc009ptm.3 Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16. Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA (By similarity). Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2. Q8VHY0; P23819: Gria2; NbExp=2; IntAct=EBI-8327479, EBI-77538; Q8VHY0; Q925T6: Grip1; NbExp=7; IntAct=EBI-8327479, EBI-537752; Q8VHY0; Q9WTW1: Grip2; Xeno; NbExp=2; IntAct=EBI-8327479, EBI-936045; Cell membrane ; Single-pass type I membrane protein ; Extracellular side Apical cell membrane ; Single-pass type I membrane protein ; Extracellular side Cell projection, lamellipodium membrane ; Single-pass type I membrane protein ; Extracellular side Cell surface Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. A fraction may undergo cell surface proteolysis and secretion (By similarity). Localizes to the plasma membrane of oligodendrocytes (PubMed:12458226). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VHY0-1; Sequence=Displayed; Name=2; IsoId=Q8VHY0-2; Sequence=VSP_015656; Name=3; IsoId=Q8VHY0-3; Sequence=VSP_015657, VSP_015658; Expressed in microcascular pericytes and not endothelial cells. O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation. Involved in interaction with MMP16 and ITGA4 (By similarity). Phosphorylation by PRKCA regulates its subcellular location and function in cell motility. Mice are unresponsive to PDGF-AA through PDGF- alpha receptor. Valuable marker for several incompletely differentiated precursor cells. Sequence=BAC26150.1; Type=Frameshift; Evidence=; activation of MAPK activity angiogenesis protein binding collagen binding plasma membrane inflammatory response signal transduction transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development cell proliferation glial cell migration cell surface negative regulation of neuron projection development membrane integral component of membrane neuron remodeling apical plasma membrane protein kinase binding cell differentiation lamellipodium membrane intracellular signal transduction cell projection tissue remodeling positive regulation of peptidyl-tyrosine phosphorylation uc009ptm.1 uc009ptm.2 uc009ptm.3 
ENSMUST00000035667.9 Trim62 ENSMUST00000035667.9 tripartite motif-containing 62, transcript variant 2 (from RefSeq NM_178110.3) ENSMUST00000035667.1 ENSMUST00000035667.2 ENSMUST00000035667.3 ENSMUST00000035667.4 ENSMUST00000035667.5 ENSMUST00000035667.6 ENSMUST00000035667.7 ENSMUST00000035667.8 NM_178110 Q80V85 TRI62_MOUSE Trim62 uc008uvo.1 uc008uvo.2 uc008uvo.3 E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C- type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with the ubiquitin-conjugating enzyme, UBE2D2. Cytoplasm The RING finger is required for ubiquitin ligase activity. Polyubiquitinated, autoubiquitinated in the presence of UBE2D2. Increased susceptibility to fungal infection. Belongs to the TRIM/RBCC family. ubiquitin-protein transferase activity cytoplasm zinc ion binding negative regulation of epithelial to mesenchymal transition protein ubiquitination transferase activity negative regulation of viral transcription positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell metal ion binding positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity regulation of viral release from host cell uc008uvo.1 uc008uvo.2 uc008uvo.3 
ENSMUST00000035672.5 Ppl ENSMUST00000035672.5 periplakin (from RefSeq NM_008909.2) ENSMUST00000035672.1 ENSMUST00000035672.2 ENSMUST00000035672.3 ENSMUST00000035672.4 G5E898 G5E898_MOUSE NM_008909 Ppl uc007ybt.1 uc007ybt.2 uc007ybt.3 Belongs to the plakin or cytolinker family. cytoskeleton response to mechanical stimulus uc007ybt.1 uc007ybt.2 uc007ybt.3 
ENSMUST00000035673.8 Vhl ENSMUST00000035673.8 von Hippel-Lindau tumor suppressor (from RefSeq NM_009507.4) ENSMUST00000035673.1 ENSMUST00000035673.2 ENSMUST00000035673.3 ENSMUST00000035673.4 ENSMUST00000035673.5 ENSMUST00000035673.6 ENSMUST00000035673.7 NM_009507 Q3TTE7 Q3TTE7_MOUSE Vhl Vhlh uc009dha.1 uc009dha.2 uc009dha.3 Belongs to the VHL family. negative regulation of transcription from RNA polymerase II promoter response to hypoxia nucleus mitochondrion cytosol regulation of transcription, DNA-templated neuron differentiation VCB complex regulation of catecholamine metabolic process macromolecular complex binding response to ethanol protein heterooligomerization uc009dha.1 uc009dha.2 uc009dha.3 
ENSMUST00000035682.16 Ypel1 ENSMUST00000035682.16 yippee like 1, transcript variant 2 (from RefSeq NM_023249.6) ENSMUST00000035682.1 ENSMUST00000035682.10 ENSMUST00000035682.11 ENSMUST00000035682.12 ENSMUST00000035682.13 ENSMUST00000035682.14 ENSMUST00000035682.15 ENSMUST00000035682.2 ENSMUST00000035682.3 ENSMUST00000035682.4 ENSMUST00000035682.5 ENSMUST00000035682.6 ENSMUST00000035682.7 ENSMUST00000035682.8 ENSMUST00000035682.9 NM_023249 Q9ESC7 YPEL1_MOUSE uc007yju.1 uc007yju.2 uc007yju.3 uc007yju.4 May play a role in epithelioid conversion of fibroblasts. Nucleus At 9.5 dpc, expressed throughout the ventral mesoderm of the trunk and head. At 10.5 dpc, maintained in the ventral aspect of the axial tissues; detected in the branchial clefts, branchial arches, in the heart and in the cranial mesenchyme underlying the mid-brain. No expression in the dorsal part of the embryo, in the somatopleure nor in the splanchnopleure. At 11.0 dpc, expressed in the branchial arches in the mesenchyme underlying the ectoderm, but not the endoderm. Belongs to the yippee family. molecular_function cellular_component nucleus biological_process metal ion binding uc007yju.1 uc007yju.2 uc007yju.3 uc007yju.4 
ENSMUST00000035695.10 Rbp3 ENSMUST00000035695.10 retinol binding protein 3, interstitial (from RefSeq NM_015745.3) A0A0R4J0H3 A0A0R4J0H3_MOUSE ENSMUST00000035695.1 ENSMUST00000035695.2 ENSMUST00000035695.3 ENSMUST00000035695.4 ENSMUST00000035695.5 ENSMUST00000035695.6 ENSMUST00000035695.7 ENSMUST00000035695.8 ENSMUST00000035695.9 NM_015745 Rbp3 uc007tad.1 uc007tad.2 uc007tad.3 retinoid binding extracellular space proteolysis visual perception serine-type peptidase activity retinol binding interphotoreceptor matrix uc007tad.1 uc007tad.2 uc007tad.3 
ENSMUST00000035700.14 Camkv ENSMUST00000035700.14 CaM kinase-like vesicle-associated, transcript variant 1 (from RefSeq NM_145621.3) CAMKV_MOUSE ENSMUST00000035700.1 ENSMUST00000035700.10 ENSMUST00000035700.11 ENSMUST00000035700.12 ENSMUST00000035700.13 ENSMUST00000035700.2 ENSMUST00000035700.3 ENSMUST00000035700.4 ENSMUST00000035700.5 ENSMUST00000035700.6 ENSMUST00000035700.7 ENSMUST00000035700.8 ENSMUST00000035700.9 NM_145621 Q3UHL1 Q8VD20 uc009rnk.1 uc009rnk.2 uc009rnk.3 Does not appear to have detectable kinase activity. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with calmodulin, in the presence of calcium. Cell membrane ; Peripheral membrane protein Cytoplasmic vesicle membrane ; Peripheral membrane protein Note=Predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. May be associated with vesicular structures (By similarity). The protein kinase domain is predicted to be catalytically inactive. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. protein kinase activity calmodulin-dependent protein kinase activity calmodulin binding ATP binding plasma membrane protein phosphorylation membrane cytoplasmic vesicle membrane cytoplasmic vesicle postsynapse glutamatergic synapse uc009rnk.1 uc009rnk.2 uc009rnk.3 
ENSMUST00000035701.6 Fshr ENSMUST00000035701.6 follicle stimulating hormone receptor (from RefSeq NM_013523.3) ENSMUST00000035701.1 ENSMUST00000035701.2 ENSMUST00000035701.3 ENSMUST00000035701.4 ENSMUST00000035701.5 FSHR_MOUSE NM_013523 P35378 Q9D4C2 Q9QWV8 uc008dvx.1 uc008dvx.2 G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation (By similarity). Cell membrane ; Multi-pass membrane protein N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone. Sulfated. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. ovarian follicle development primary ovarian follicle growth regulation of protein phosphorylation regulation of systemic arterial blood pressure G-protein coupled receptor activity follicle-stimulating hormone receptor activity endosome plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway spermatogenesis spermatid development locomotory behavior G-protein coupled peptide receptor activity hormone-mediated signaling pathway cell surface cellular water homeostasis regulation of platelet-derived growth factor receptor signaling pathway regulation of protein kinase A signaling positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane protein-hormone receptor activity peptide hormone binding ovulation cycle process neuron projection development regulation of hormone metabolic process regulation of chromosome organization regulation of intracellular estrogen receptor signaling pathway positive regulation of intracellular estrogen receptor signaling pathway sperm chromatin condensation spermatogenesis, exchange of chromosomal proteins follicle-stimulating hormone signaling pathway receptor complex regulation of MAPK cascade transcytosis regulation of osteoclast differentiation negative regulation of bone resorption Sertoli cell development Sertoli cell proliferation uterus development regulation of acetylcholine metabolic process positive regulation of ERK1 and ERK2 cascade cellular response to follicle-stimulating hormone stimulus basement membrane organization uc008dvx.1 uc008dvx.2 
ENSMUST00000035715.8 Prss42 ENSMUST00000035715.8 serine protease 42 (from RefSeq NM_153099.1) ENSMUST00000035715.1 ENSMUST00000035715.2 ENSMUST00000035715.3 ENSMUST00000035715.4 ENSMUST00000035715.5 ENSMUST00000035715.6 ENSMUST00000035715.7 NM_153099 PRS42_MOUSE Prss42 Q8VIF2 Tessp2 uc009rus.1 uc009rus.2 uc009rus.3 Plays a role in spermatogenesis. Involved in germ cell survival during meiosis. Lacks protease activity in vitro. Cytoplasm Cell membrane ; Lipid-anchor, GPI-anchor Testis-specific (PubMed:23536369). Mainly detected in round spermatids at all the eminiferous epithelial stages (at protein level) (PubMed:23536369). In testis, expressed at all stages from the late pachytene primary spermatocyte to the secondary spermatocyte. Not detected at day 7 after birth. Expression is detected at day 14 and increases dramatically at day 21 and reach a peak at day 28 to remain high until day 56. Belongs to the peptidase S1 family. Lacks protease activity in vitro. serine-type endopeptidase activity extracellular space cytoplasm plasma membrane proteolysis germ cell development spermatogenesis peptidase activity serine-type peptidase activity membrane hydrolase activity cell differentiation anchored component of membrane anchored component of plasma membrane uc009rus.1 uc009rus.2 uc009rus.3 
ENSMUST00000035721.14 Prpf18 ENSMUST00000035721.14 pre-mRNA processing factor 18, transcript variant 2 (from RefSeq NM_026045.4) ENSMUST00000035721.1 ENSMUST00000035721.10 ENSMUST00000035721.11 ENSMUST00000035721.12 ENSMUST00000035721.13 ENSMUST00000035721.2 ENSMUST00000035721.3 ENSMUST00000035721.4 ENSMUST00000035721.5 ENSMUST00000035721.6 ENSMUST00000035721.7 ENSMUST00000035721.8 ENSMUST00000035721.9 NM_026045 PRP18_MOUSE Prp18 Q3UX46 Q8BM39 Q8BZ54 uc008iex.1 uc008iex.2 uc008iex.3 Participates in the second step of pre-mRNA splicing. Heterodimer with PPIH. Interacts with PRPF4 and with the spliceosome. Part of a complex containing U4/U6 snRNPs (By similarity). Nucleus speckle Note=Colocalizes with spliceosomal snRNPs. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BM39-1; Sequence=Displayed; Name=2; IsoId=Q8BM39-2; Sequence=VSP_008329, VSP_008330; [Isoform 2]: May be due to an intron retention. Belongs to the PRP18 family. Sequence=BAC29527.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; generation of catalytic spliceosome for second transesterification step nucleus spliceosomal complex U5 snRNP mRNA processing RNA splicing membrane nuclear speck negative regulation of cellular protein metabolic process U4/U6 x U5 tri-snRNP complex U2-type post-spliceosomal complex nuclear retention of unspliced pre-mRNA at the site of transcription second spliceosomal transesterification activity uc008iex.1 uc008iex.2 uc008iex.3 
ENSMUST00000035724.5 Akna ENSMUST00000035724.5 AT-hook transcription factor, transcript variant 11 (from RefSeq NM_001426151.1) AKNA_MOUSE Akna ENSMUST00000035724.1 ENSMUST00000035724.2 ENSMUST00000035724.3 ENSMUST00000035724.4 Kiaa1968 NM_001426151 Q3TC64 Q3TDM3 Q3U3N4 Q6ZPF9 Q80VW7 Q8CFV0 Q8R114 uc008tgb.1 uc008tgb.2 uc008tgb.3 uc008tgb.4 uc008tgb.5 Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (PubMed:30787442). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (PubMed:30787442). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (PubMed:30787442). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (PubMed:30787442). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (By similarity). Binds to A/T-rich promoters (By similarity). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). Interacts with DCTN1 (PubMed:30787442). Interacts with MAPRE1/EB1 (PubMed:30787442). Interacts with ODF2 (PubMed:30787442). Interacts with CAMSAP3 (PubMed:30787442). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Nucleus Note=Localizes to the distal part of the subdistal appendages of the mother centriole in interphase (PubMed:30787442). Also found at the proximal ends of centrioles and along microtubules (PubMed:30787442). The centrosomal localization is dependent on centrioles (PubMed:30787442). Dissociates from centrosomes during M-phase without proteolytic degradation and reassembles at the centrosomes during late telophase and early G1 phase (PubMed:30787442). Dissociation and reassembly is regulated by phosphorylation (PubMed:30787442). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80VW7-1; Sequence=Displayed; Name=2; IsoId=Q80VW7-2; Sequence=VSP_025942, VSP_025943; Name=3; IsoId=Q80VW7-3; Sequence=VSP_025944, VSP_025945; Name=4; IsoId=Q80VW7-4; Sequence=VSP_025941, VSP_025944, VSP_025945; Expressed in neural stem cells isolated at the peak of subventricular zone (SVZ): localizes at the subdistal appendages of the mother centriole in specific subtypes of neural stem cells and in almost all basal progenitors. During development, expressed when the subventricular zone (SVZ) is generated (low at 11 dpc, high at 14 dpc and low at 18 dpc). Phosphorylated; phosphorylation regulates dissociation from and reassembly at the centrosome. Neonatal lethality: mice fail to thrive and most of them die by postnatal day 10 (PubMed:21606955). Mice display systemic inflammation, predominantly in the lungs, accompanied by enhanced leukocyte infiltration and alveolar destruction (PubMed:21606955). Belongs to the AKNA family. Sequence=BAC98278.1; Type=Erroneous initiation; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding fibrillar center epithelial to mesenchymal transition DNA binding protein binding nucleus nucleoplasm cytoplasm centrosome centriole cytosol cytoskeleton microtubule nervous system development neuroblast division in subventricular zone intracellular membrane-bounded organelle positive regulation of transcription from RNA polymerase II promoter regulation of inflammatory response delamination neuroblast delamination uc008tgb.1 uc008tgb.2 uc008tgb.3 uc008tgb.4 uc008tgb.5 
ENSMUST00000035725.7 Brk1 ENSMUST00000035725.7 BRICK1, SCAR/WAVE actin-nucleating complex subunit (from RefSeq NM_133937.1) BRK1_MOUSE ENSMUST00000035725.1 ENSMUST00000035725.2 ENSMUST00000035725.3 ENSMUST00000035725.4 ENSMUST00000035725.5 ENSMUST00000035725.6 NM_133937 Q3TLB8 Q91VR8 uc009dgz.1 uc009dgz.2 Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705). Homotrimer when in free form. Directly interacts with WASF2. Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1 (By similarity). Cytoplasm, cytoskeleton Belongs to the BRK1 family. in utero embryonic development cytoplasm cytoskeleton actin filament organization regulation of actin polymerization or depolymerization positive regulation of cell proliferation positive regulation of lamellipodium assembly Rac protein signal transduction lamellipodium actin cytoskeleton organization SCAR complex positive regulation of protein complex assembly identical protein binding macromolecular complex binding Rac GTPase binding cell motility protein homotrimerization positive regulation of Arp2/3 complex-mediated actin nucleation uc009dgz.1 uc009dgz.2 
ENSMUST00000035732.5 Tekt3 ENSMUST00000035732.5 tektin 3 (from RefSeq NM_027660.1) ENSMUST00000035732.1 ENSMUST00000035732.2 ENSMUST00000035732.3 ENSMUST00000035732.4 NM_027660 Q6X6Z7 TEKT3_MOUSE uc007jkl.1 uc007jkl.2 uc007jkl.3 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Required for normal sperm mobility (PubMed:18951373). Interacts with TEKT1, TEKT2, TEKT4 and TEKT5. Cytoplasm, cytoskeleton, cilium axoneme Cell projection, cilium, flagellum Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane ; Peripheral membrane protein Note=In spermatozoa, preferentially localizes to the flagella, but also found in the head (By similarity). In the sperm flagellum, localizes to the periaxonemal region where it associates with the mitochondrial sheath and outer dense fibers (By similarity). Not detected in the central axonemal region of the flagellum (By similarity). Associates with the acrosome membrane in the equatorial segment of the sperm head (By similarity). Also detected just below the plasma membrane in the post- acrosomal region where it might localize to the postacrosomal dense lamina (By similarity). However, other studies report little or no expression in the postacrosomal region (By similarity). Translocates from the postacrosomal region to the equatorial segment after sperm activation (By similarity). Retained in the postacromal region, but not the equatorial segment, following the acrosome reaction (By similarity). Some studies report strong expression in the anterior cap region (By similarity). However, other studies report little or no expression in the acrosomal cap (By similarity). Expressed preferentially in testis. Expressed predominantly in late pachytene spermatocytes and early round spermatids (PubMed:14735490). Expressed in spermatozoa (PubMed:36708031). N- and O-glycosylated. May be proteolytically processed during the epididymal transit of spermatozoa. Sperm with reduced motility (47%) and forward progression and increased flagellar structural bending defects. However, normal fertility is maintained. Belongs to the tektin family. acrosomal membrane outer acrosomal membrane cytoplasm cilium microtubule cytoskeleton membrane flagellated sperm motility cytoplasmic vesicle motile cilium sperm flagellum cell projection cilium assembly cilium movement involved in cell motility regulation of brood size uc007jkl.1 uc007jkl.2 uc007jkl.3 
ENSMUST00000035735.11 Ndufa4l2 ENSMUST00000035735.11 Ndufa4, mitochondrial complex associated like 2 (from RefSeq NM_001098789.1) ENSMUST00000035735.1 ENSMUST00000035735.10 ENSMUST00000035735.2 ENSMUST00000035735.3 ENSMUST00000035735.4 ENSMUST00000035735.5 ENSMUST00000035735.6 ENSMUST00000035735.7 ENSMUST00000035735.8 ENSMUST00000035735.9 NM_001098789 NUA4L_MOUSE Q4FZG9 uc007hjt.1 uc007hjt.2 uc007hjt.3 uc007hjt.4 uc007hjt.5 Belongs to the complex I NDUFA4 subunit family. mitochondrial respiratory chain complex IV biological_process electron transport chain hydrogen ion transmembrane transport cytochrome-c oxidase activity uc007hjt.1 uc007hjt.2 uc007hjt.3 uc007hjt.4 uc007hjt.5 
ENSMUST00000035751.12 L3mbtl1 ENSMUST00000035751.12 L3MBTL1 histone methyl-lysine binding protein (from RefSeq NM_001081338.3) A2A5N8 ENSMUST00000035751.1 ENSMUST00000035751.10 ENSMUST00000035751.11 ENSMUST00000035751.2 ENSMUST00000035751.3 ENSMUST00000035751.4 ENSMUST00000035751.5 ENSMUST00000035751.6 ENSMUST00000035751.7 ENSMUST00000035751.8 ENSMUST00000035751.9 Kiaa0681 L3mbt L3mbtl LMBL1_MOUSE NM_001081338 Q5DU20 uc008nsd.1 uc008nsd.2 uc008nsd.3 Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53- target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys- 860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis (By similarity). Homodimer. Interacts with RB1/RB (when monomethylated at 'Lys- 860'). Interacts with p53/TP53 (when monomethylated at 'Lys-382'). Interacts with CBX3, ETV6, KMT5A and VCP/p97 (By similarity). Nucleus Note=Excluded from the nucleolus. Does not colocalize with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex (By similarity). Highly expressed in brain, testis, eyes, and ES cells. The MBT repeat 2 specifically recognizes and binds monomethylated and dimethylated proteins. In contrast, it does not bind trimethylated proteins. The MBT repeat 1 does not bind methylated peptides but inserts a proline ring in a Pro-Ser-Ser/Thr sequence context (By similarity). Ubiquitinated in a VCP/p97-dependent way following DNA damage, leading to its removal from DNA damage sites, promoting accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited to DNA damage sites. No visible phenotype. Mice develop and reproduc normally. Mice were followed for more than 2 years, without any alteration in normal lifespan or survival with or without sublethal irradiation. chromatin condensed chromosome chromatin binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm plasma membrane chromatin organization regulation of transcription, DNA-templated regulation of mitotic nuclear division zinc ion binding hemopoiesis nucleosome binding nucleosomal histone binding SAM domain binding methylated histone binding regulation of gene expression, epigenetic histone binding identical protein binding regulation of megakaryocyte differentiation negative regulation of transcription, DNA-templated metal ion binding nucleolus uc008nsd.1 uc008nsd.2 uc008nsd.3 
ENSMUST00000035757.13 Pramel5 ENSMUST00000035757.13 PRAME like 5 (from RefSeq NM_001085418.2) ENSMUST00000035757.1 ENSMUST00000035757.10 ENSMUST00000035757.11 ENSMUST00000035757.12 ENSMUST00000035757.2 ENSMUST00000035757.3 ENSMUST00000035757.4 ENSMUST00000035757.5 ENSMUST00000035757.6 ENSMUST00000035757.7 ENSMUST00000035757.8 ENSMUST00000035757.9 NM_001085418 OTTMUSG00000010540 Pramel5 Q7TPY4 Q7TPY4_MOUSE uc008vra.1 uc008vra.2 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vra.1 uc008vra.2 
ENSMUST00000035766.13 Wdr44 ENSMUST00000035766.13 WD repeat domain 44, transcript variant 1 (from RefSeq NM_175180.3) ENSMUST00000035766.1 ENSMUST00000035766.10 ENSMUST00000035766.11 ENSMUST00000035766.12 ENSMUST00000035766.2 ENSMUST00000035766.3 ENSMUST00000035766.4 ENSMUST00000035766.5 ENSMUST00000035766.6 ENSMUST00000035766.7 ENSMUST00000035766.8 ENSMUST00000035766.9 NM_175180 Q3UT13 Q6NVE8 Q8BTS1 RPH11 WDR44_MOUSE Wdr44 uc009sux.1 uc009sux.2 uc009sux.3 uc009sux.4 uc009sux.5 This gene encodes a protein containing multiple WD repeats. The encoded protein may play a role in vesicle trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (By similarity). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (By similarity). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (By similarity). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (By similarity). Interacts with the GTP-bound form of RAB11 when membrane- associated. Interacts with GRAF1/ARHGAP26 or GRAF2/ARHGAP10; the interaction connects the endoplasmic reticulum (ER) with the endosomal tubule (By similarity). Interacts (via FFAT-like motif) with VAPA (via MSP domain) or VAPB (via MSP domain); the interaction connects the ER with the endosomal tubule (By similarity). Does not bind to other Rab and Rho small G proteins. Cytoplasm, cytosol Cytoplasm, perinuclear region Endosome membrane Golgi apparatus, trans-Golgi network Note=Colocalized with RAB11 along microtubules oriented toward lamellipodia. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NVE8-1; Sequence=Displayed; Name=2; IsoId=Q6NVE8-2; Sequence=VSP_021811; The FFAT-like motif is important for interaction with VAPA or VAPB. Phosphorylated by ATK1; the phosphorylation stabilizes its interaction with RAB11A and RAB11B. cytoplasm endosome Golgi apparatus cytosol microtubule endosome membrane membrane Rab GTPase binding regulation of cell migration perinuclear region of cytoplasm uc009sux.1 uc009sux.2 uc009sux.3 uc009sux.4 uc009sux.5 
ENSMUST00000035773.14 Sos2 ENSMUST00000035773.14 SOS Ras/Rho guanine nucleotide exchange factor 2 (from RefSeq NM_001135559.1) A0A0A0MQ87 A0A0A0MQ87_MOUSE ENSMUST00000035773.1 ENSMUST00000035773.10 ENSMUST00000035773.11 ENSMUST00000035773.12 ENSMUST00000035773.13 ENSMUST00000035773.2 ENSMUST00000035773.3 ENSMUST00000035773.4 ENSMUST00000035773.5 ENSMUST00000035773.6 ENSMUST00000035773.7 ENSMUST00000035773.8 ENSMUST00000035773.9 NM_001135559 Sos2 uc007nso.1 uc007nso.2 uc007nso.3 uc007nso.4 nucleosome DNA binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity small GTPase mediated signal transduction regulation of Rho protein signal transduction protein heterodimerization activity positive regulation of small GTPase mediated signal transduction uc007nso.1 uc007nso.2 uc007nso.3 uc007nso.4 
ENSMUST00000035775.9 Lsm7 ENSMUST00000035775.9 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated, transcript variant 4 (from RefSeq NM_025349.2) ENSMUST00000035775.1 ENSMUST00000035775.2 ENSMUST00000035775.3 ENSMUST00000035775.4 ENSMUST00000035775.5 ENSMUST00000035775.6 ENSMUST00000035775.7 ENSMUST00000035775.8 LSM7_MOUSE NM_025349 Q9CQQ8 uc007gfa.1 uc007gfa.2 Plays a role in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Interacts with TACC1. Nucleus Belongs to the snRNP Sm proteins family. mRNA splicing, via spliceosome nuclear-transcribed mRNA catabolic process RNA binding protein binding nucleus spliceosomal complex U6 snRNP U12-type spliceosomal complex cytoplasm mRNA processing mRNA catabolic process RNA splicing U4/U6 x U5 tri-snRNP complex protein heterodimerization activity U2-type prespliceosome U2-type precatalytic spliceosome catalytic step 2 spliceosome Lsm1-7-Pat1 complex uc007gfa.1 uc007gfa.2 
ENSMUST00000035776.10 Dnttip2 ENSMUST00000035776.10 deoxynucleotidyltransferase, terminal, interacting protein 2 (from RefSeq NM_153806.2) ENSMUST00000035776.1 ENSMUST00000035776.2 ENSMUST00000035776.3 ENSMUST00000035776.4 ENSMUST00000035776.5 ENSMUST00000035776.6 ENSMUST00000035776.7 ENSMUST00000035776.8 ENSMUST00000035776.9 NM_153806 Q3TQW8 Q3UX19 Q8R2M2 TDIF2_MOUSE uc008rep.1 uc008rep.2 uc008rep.3 Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Forms a ternary complex with DNTT and core histone; interaction with PCNA releases DNTT and H2A/H2B histones from this ternary complex. Interacts with ESR1, ESR2, PPARG and RXRA. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus Nucleus, nucleolus nucleus nucleolus biological_process uc008rep.1 uc008rep.2 uc008rep.3 
ENSMUST00000035777.10 Mon1b ENSMUST00000035777.10 MON1 homolog B, secretory traffciking associated, transcript variant 1 (from RefSeq NM_173015.3) ENSMUST00000035777.1 ENSMUST00000035777.2 ENSMUST00000035777.3 ENSMUST00000035777.4 ENSMUST00000035777.5 ENSMUST00000035777.6 ENSMUST00000035777.7 ENSMUST00000035777.8 ENSMUST00000035777.9 Kiaa0872 MON1B_MOUSE NM_173015 Q69ZX1 Q6P5V5 Q8BMQ8 uc009nno.1 uc009nno.2 uc009nno.3 uc009nno.4 Interacts with CCNT2; down-regulates CCNT2-mediated activation of viral promoters during herpes simplex virus 1/HHV-1 infection. Found in a complex with RMC1, CCZ1 MON1A and MON1B. Belongs to the MON1/SAND family. molecular_function cytoplasm protein targeting to vacuole early viral transcription late viral transcription Mon1-Ccz1 complex uc009nno.1 uc009nno.2 uc009nno.3 uc009nno.4 
ENSMUST00000035779.15 Acsl3 ENSMUST00000035779.15 acyl-CoA synthetase long-chain family member 3, transcript variant 1 (from RefSeq NM_028817.4) ACSL3_MOUSE Acs3 Acsl3 ENSMUST00000035779.1 ENSMUST00000035779.10 ENSMUST00000035779.11 ENSMUST00000035779.12 ENSMUST00000035779.13 ENSMUST00000035779.14 ENSMUST00000035779.2 ENSMUST00000035779.3 ENSMUST00000035779.4 ENSMUST00000035779.5 ENSMUST00000035779.6 ENSMUST00000035779.7 ENSMUST00000035779.8 ENSMUST00000035779.9 Facl3 NM_028817 Q8K1J7 Q9CZW4 uc007bqo.1 uc007bqo.2 uc007bqo.3 Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl- CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422; Evidence=; Reaction=(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:36139, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61526, ChEBI:CHEBI:72745, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36140; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:456215; EC=6.2.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19714; Evidence=; Reaction=15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15- hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52116, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:78832, ChEBI:CHEBI:136409, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52117; Evidence=; Reaction=12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12- hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52112, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:90718, ChEBI:CHEBI:136408, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52113; Evidence=; Reaction=5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5- hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52108, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65341, ChEBI:CHEBI:136407, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52109; Evidence=; Reaction=14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15- epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52016, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:84024, ChEBI:CHEBI:136117, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52017; Evidence=; Reaction=11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12- epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52012, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:76625, ChEBI:CHEBI:136115, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52013; Evidence=; Reaction=a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:48340, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:59558, ChEBI:CHEBI:90546, ChEBI:CHEBI:456215; EC=6.2.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48341; Evidence=; Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl- CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30752; Evidence=; Reaction=ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA; Xref=Rhea:RHEA:33619, ChEBI:CHEBI:30616, ChEBI:CHEBI:30807, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33620; Evidence=; Reaction=ATP + CoA + dodecanoate = AMP + diphosphate + dodecanoyl-CoA; Xref=Rhea:RHEA:33623, ChEBI:CHEBI:18262, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33624; Evidence=; Reaction=ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl- CoA; Xref=Rhea:RHEA:33615, ChEBI:CHEBI:25629, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33616; Evidence=; Reaction=ATP + CoA + eicosanoate = AMP + diphosphate + eicosanoyl-CoA; Xref=Rhea:RHEA:46208, ChEBI:CHEBI:30616, ChEBI:CHEBI:32360, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46209; Evidence=; Reaction=(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:33607, ChEBI:CHEBI:30616, ChEBI:CHEBI:30823, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33608; Evidence=; Reaction=(9Z)-hexadecenoate + ATP + CoA = (9Z)-hexadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:33647, ChEBI:CHEBI:30616, ChEBI:CHEBI:32372, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33648; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)- octadecadienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:33651, ChEBI:CHEBI:30245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:456215; Evidence=; Reaction=(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA = (9Z,12Z,15Z)- octadecatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:44936, ChEBI:CHEBI:30616, ChEBI:CHEBI:32387, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:74034, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44937; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:44932, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:74298, ChEBI:CHEBI:77016, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44933; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:67848, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58562, ChEBI:CHEBI:73862, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67849; Evidence=; Reaction=a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:38883, ChEBI:CHEBI:28868, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:77636, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38884; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Mitochondrion outer membrane ; Single-pass type III membrane protein Peroxisome membrane ; Single-pass type III membrane protein Microsome membrane ; Single-pass type III membrane protein Endoplasmic reticulum membrane ; Single-pass type III membrane protein High expression in ob/ob mice (obese) and mice fed at high sucrose diet. Belongs to the ATP-dependent AMP-binding enzyme family. nucleotide binding long-chain fatty acid metabolic process catalytic activity acyl-CoA ligase activity long-chain fatty acid-CoA ligase activity ATP binding mitochondrion mitochondrial outer membrane peroxisome peroxisomal membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus lipid particle lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process brain development response to nutrient response to organic cyclic compound membrane integral component of membrane ligase activity protein kinase binding protein domain specific binding organelle membrane very-low-density lipoprotein particle assembly positive regulation of Golgi to plasma membrane protein transport intracellular membrane-bounded organelle long-chain fatty acid import arachidonate-CoA ligase activity perinuclear region of cytoplasm positive regulation of secretion decanoate--CoA ligase activity positive regulation of phosphatidylcholine biosynthetic process uc007bqo.1 uc007bqo.2 uc007bqo.3 
ENSMUST00000035780.4 Oma1 ENSMUST00000035780.4 OMA1 zinc metallopeptidase, transcript variant 1 (from RefSeq NM_025909.4) ENSMUST00000035780.1 ENSMUST00000035780.2 ENSMUST00000035780.3 NM_025909 OMA1_MOUSE Oma1 Q3UWN9 Q9D8H7 uc008txq.1 uc008txq.2 uc008txq.3 Metalloprotease that is part of the quality control system in the inner membrane of mitochondria (PubMed:20038678, PubMed:22433842, PubMed:24550258, PubMed:24719224, PubMed:24616225, PubMed:26785494). Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1 (PubMed:20038678, PubMed:22433842, PubMed:24550258, PubMed:24616225, PubMed:26785494). Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion (PubMed:20038678, PubMed:22433842, PubMed:24550258, PubMed:24616225, PubMed:26785494, PubMed:26783299). Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae (By similarity). In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome (By similarity). May also cleave UQCC3 in response to mitochondrial depolarization (By similarity). Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (By similarity). Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (PubMed:22433842). Binds cardiolipin, possibly regulating its protein turnover (PubMed:31819158). Required for the stability of the respiratory supercomplexes (PubMed:26365306). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Protease activity is activated upon autocatalytic cleavage in response to mitochondrial depolarization. Homooligomer. Mitochondrion inner membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D8H7-1; Sequence=Displayed; Name=2; IsoId=Q9D8H7-2; Sequence=VSP_027959, VSP_027960; The stress-sensor region regulates proteolysis and activation. Autocatalytically cleaved in response to mitochondrial depolarization both at the N-terminus and C-terminus to generate the short active form (S-OMA1) (PubMed:24550258, PubMed:24719224). Autocatalytic processing at the C-terminus takes place at residues 443- 452 (PubMed:24719224). The S-OMA1 form is unstable (PubMed:24719224). Degradaded by YMEL1 in response to membrane depolarization (By similarity). Protein turnover is regulated by prohibitin (PHB and PHB2), which promotes degradation of OMA1 in a cardiolipin-binding manner (PubMed:31819158). May form a redox-dependent disulfide bond (By similarity). Exists in a semi-oxidized state and is activated by prolonged hypoxia (By similarity). Mice develop normally with males and females being fertile (PubMed:22433842). They however display transcriptional changes in genes of lipid and glucose metabolic pathways and substantial alterations in circulating blood parameters (PubMed:22433842). Moreover, mice exhibit an increase in body weight due to increased adipose mass, hepatic steatosis, decreased energy expenditure and impaired thermogenenesis (PubMed:22433842). Mice are protected against heart failure by averting cardiomyocyte death in different murine heart failure models (PubMed:29593106). Mice with a double, cardiomyocyte-specific gene disruption of Yme1l and Oma1 have normal cardiac function and do not display myocardial fibrosis, contrary to mice with a single, cardiomyocyte-specific disruption of Yme1l (PubMed:26785494). Likewise, cardiomyocyte mitochondria have normal morphology (PubMed:26785494). Mice with a skeletal muscle Yme1l gene disruption plus a double, cardiomyocyte-specific gene disruption of Yme1l and Oma1 display normal glucose tolerance (PubMed:26785494). Belongs to the peptidase M48 family. diet induced thermogenesis metalloendopeptidase activity mitochondrion mitochondrial inner membrane glucose metabolic process proteolysis misfolded or incompletely synthesized protein catabolic process lipid metabolic process mitochondrion organization peptidase activity metallopeptidase activity negative regulation of mitochondrial fusion membrane integral component of membrane hydrolase activity mitochondrial membrane mitochondrial protein processing cristae formation metal ion binding energy homeostasis uc008txq.1 uc008txq.2 uc008txq.3 
ENSMUST00000035797.16 Rab26 ENSMUST00000035797.16 RAB26, member RAS oncogene family (from RefSeq NM_177375.2) ENSMUST00000035797.1 ENSMUST00000035797.10 ENSMUST00000035797.11 ENSMUST00000035797.12 ENSMUST00000035797.13 ENSMUST00000035797.14 ENSMUST00000035797.15 ENSMUST00000035797.2 ENSMUST00000035797.3 ENSMUST00000035797.4 ENSMUST00000035797.5 ENSMUST00000035797.6 ENSMUST00000035797.7 ENSMUST00000035797.8 ENSMUST00000035797.9 NM_177375 Q504M8 RAB26_MOUSE uc008awu.1 uc008awu.2 uc008awu.3 uc008awu.4 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity). Plays a role in the secretion of amylase from acinar granules in the parotid gland. Interacts with ADRA2B (By similarity). Interacts with RIMS1. Cytoplasmic vesicle, secretory vesicle membrane ; Lipid-anchor ; Cytoplasmic side Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side Note=Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location. Detected in zymogenic cells in the stomach. Belongs to the small GTPase superfamily. Rab family. Golgi membrane nucleotide binding GTPase activity protein binding GTP binding Golgi apparatus intracellular protein transport protein transport membrane regulation of exocytosis GMP binding transport vesicle membrane secretory granule membrane intrinsic component of plasma membrane cytoplasmic vesicle Rab protein signal transduction exocrine system development Golgi to plasma membrane protein transport regulated exocytosis anchored component of synaptic vesicle membrane regulation of protein catabolic process at presynapse, modulating synaptic transmission uc008awu.1 uc008awu.2 uc008awu.3 uc008awu.4 
ENSMUST00000035799.6 Fgl2 ENSMUST00000035799.6 fibrinogen-like protein 2 (from RefSeq NM_008013.4) ENSMUST00000035799.1 ENSMUST00000035799.2 ENSMUST00000035799.3 ENSMUST00000035799.4 ENSMUST00000035799.5 Fgl2 NM_008013 Q544K3 Q544K3_MOUSE fgl2 uc008wom.1 uc008wom.2 uc008wom.3 uc008wom.4 proteolysis peptidase activity uc008wom.1 uc008wom.2 uc008wom.3 uc008wom.4 
ENSMUST00000035804.9 Cdo1 ENSMUST00000035804.9 cysteine dioxygenase 1, cytosolic, transcript variant 2 (from RefSeq NR_151681.1) CDO1_MOUSE ENSMUST00000035804.1 ENSMUST00000035804.2 ENSMUST00000035804.3 ENSMUST00000035804.4 ENSMUST00000035804.5 ENSMUST00000035804.6 ENSMUST00000035804.7 ENSMUST00000035804.8 NR_151681 P60334 Q3UED8 uc008evt.1 uc008evt.2 uc008evt.3 Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. Reaction=L-cysteine + O2 = 3-sulfino-L-alanine + H(+); Xref=Rhea:RHEA:20441, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35235, ChEBI:CHEBI:61085; EC=1.13.11.20; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20442; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 Fe(2+) cation per subunit. Ni(2+) and Zn(2+) can be used to a lesser extent. ; Kinetic parameters: KM=3.4 mM for L-cysteine ; Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. Monomer. Highest expression in liver. Also expressed in kidney, lung, brain and small intestine. The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen. Belongs to the cysteine dioxygenase family. iron ion binding cytosol plasma membrane lactation ferrous iron binding response to organonitrogen compound oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen cysteine dioxygenase activity L-cysteine catabolic process L-cysteine catabolic process to taurine taurine metabolic process response to glucagon taurine biosynthetic process response to amino acid response to ethanol metal ion binding dioxygenase activity response to glucocorticoid response to cAMP oxidation-reduction process uc008evt.1 uc008evt.2 uc008evt.3 
ENSMUST00000035812.14 Ttl ENSMUST00000035812.14 tubulin tyrosine ligase (from RefSeq NM_027192.2) ENSMUST00000035812.1 ENSMUST00000035812.10 ENSMUST00000035812.11 ENSMUST00000035812.12 ENSMUST00000035812.13 ENSMUST00000035812.2 ENSMUST00000035812.3 ENSMUST00000035812.4 ENSMUST00000035812.5 ENSMUST00000035812.6 ENSMUST00000035812.7 ENSMUST00000035812.8 ENSMUST00000035812.9 NM_027192 P38585 Q8R1L7 Q8VEG2 TTL_MOUSE uc008mhe.1 uc008mhe.2 uc008mhe.3 uc008mhe.4 Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin. Reaction=ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl- [tubulin] + L-tyrosine = ADP + C-terminal L-alpha-aminoacyl-L- glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate; Xref=Rhea:RHEA:17605, Rhea:RHEA-COMP:16434, Rhea:RHEA-COMP:16435, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58315, ChEBI:CHEBI:149554, ChEBI:CHEBI:149555, ChEBI:CHEBI:456216; EC=6.3.2.25; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence=; Monomer. Belongs to the tubulin--tyrosine ligase family. nucleotide binding microtubule cytoskeleton organization tubulin-tyrosine ligase activity ATP binding cell microtubule cellular protein modification process ligase activity C-terminal protein-tyrosinylation regulation of axon extension positive regulation of mitotic cell cycle regulation of metaphase plate congression uc008mhe.1 uc008mhe.2 uc008mhe.3 uc008mhe.4 
ENSMUST00000035813.9 Ppp1r9a ENSMUST00000035813.9 protein phosphatase 1, regulatory subunit 9A, transcript variant 1 (from RefSeq NM_181595.4) ENSMUST00000035813.1 ENSMUST00000035813.2 ENSMUST00000035813.3 ENSMUST00000035813.4 ENSMUST00000035813.5 ENSMUST00000035813.6 ENSMUST00000035813.7 ENSMUST00000035813.8 NM_181595 Neurabin Ppp1r9a Q7TN74 Q7TN74_MOUSE uc009avy.1 uc009avy.2 Cytoplasm, cytoskeleton protein binding cytoplasm cytosol cytoskeleton actin filament organization aging protein C-terminus binding protein phosphatase 1 binding positive regulation of neuron projection development postsynaptic density actin cytoskeleton calcium-mediated signaling protein kinase binding protein domain specific binding lamellipodium filopodium dendrite growth cone regulation of actin filament polymerization cortical actin cytoskeleton neuron projection development neuromuscular junction protein homodimerization activity neuron projection neuronal cell body dendritic spine ion channel binding dendritic spine neck macromolecular complex binding synapse positive regulation of protein kinase activity neuron development modulation of synaptic transmission actin filament binding GTPase binding regulation of filopodium assembly negative regulation of stress fiber assembly regulation of synapse structural plasticity regulation of synapse assembly excitatory postsynaptic potential positive regulation of dendritic spine development regulation of dendritic spine morphogenesis cellular response to toxic substance postsynaptic actin cytoskeleton postsynaptic actin cytoskeleton organization glutamatergic synapse negative regulation of long-term synaptic potentiation positive regulation of long term synaptic depression negative regulation of spontaneous neurotransmitter secretion growth cone lamellipodium uc009avy.1 uc009avy.2 
ENSMUST00000035822.2 Calhm2 ENSMUST00000035822.2 calcium homeostasis modulator family member 2 (from RefSeq NM_133746.5) CAHM2_MOUSE ENSMUST00000035822.1 Fam26b NM_133746 Q3TDQ7 Q8BT85 Q8C246 Q8VEC4 uc008hur.1 uc008hur.2 uc008hur.3 uc008hur.4 Pore-forming subunit of a voltage-gated ion channel. Membrane ; Multi-pass membrane protein Belongs to the CALHM family. Sequence=BAC25382.1; Type=Frameshift; Evidence=; integral component of plasma membrane ion transport membrane integral component of membrane positive regulation of apoptotic process uc008hur.1 uc008hur.2 uc008hur.3 uc008hur.4 
ENSMUST00000035836.14 Inppl1 ENSMUST00000035836.14 inositol polyphosphate phosphatase-like 1, transcript variant 1 (from RefSeq NM_010567.3) ENSMUST00000035836.1 ENSMUST00000035836.10 ENSMUST00000035836.11 ENSMUST00000035836.12 ENSMUST00000035836.13 ENSMUST00000035836.2 ENSMUST00000035836.3 ENSMUST00000035836.4 ENSMUST00000035836.5 ENSMUST00000035836.6 ENSMUST00000035836.7 ENSMUST00000035836.8 ENSMUST00000035836.9 Inppl1 NM_010567 O08611 Q0VDX5 Q6P549 Q80YB9 Q9JLL7 SHIP2_MOUSE Ship2 uc009iph.1 uc009iph.2 uc009iph.3 uc009iph.4 Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10958682). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:11343120). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (PubMed:14744864). Confers resistance to dietary obesity (PubMed:15654325). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (PubMed:14744864). Part of a signaling pathway that regulates actin cytoskeleton remodeling (By similarity). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (By similarity). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (By similarity). Regulates cell adhesion and cell spreading (PubMed:29749928). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (By similarity). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K- dependent Rac1 activation (By similarity). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC- gamma-RIIA receptor (FCGR2A) (By similarity). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:10789675, PubMed:15456754). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (By similarity). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (By similarity). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (PubMed:15557176, PubMed:16179375). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (PubMed:15557176, PubMed:16179375). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + phosphate; Xref=Rhea:RHEA:25528, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57658, ChEBI:CHEBI:57836; EC=3.1.3.86; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25529; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + phosphate; Xref=Rhea:RHEA:43548, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:83416, ChEBI:CHEBI:83417; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43549; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol- 3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho- (1D-myo-inositol-3,4-bisphosphate) + phosphate; Xref=Rhea:RHEA:43556, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:83420, ChEBI:CHEBI:83422; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43557; Evidence=; Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane. Enzymatic activity is enhanced in the presence of phosphatidylserine (By similarity). Interacts with tyrosine phosphorylated form of SHC1 (By similarity). Interacts with EGFR (By similarity). Upon stimulation by the EGF signaling pathway, it forms a complex with SHC1 and EGFR (By similarity). Interacts with cytoskeletal protein SORBS3/vinexin, promoting its localization to the periphery of cells (By similarity). Forms a complex with filamin (FLNA or FLNB), actin, GPIb (GP1BA or GP1BB) that regulates cortical and submembraneous actin (By similarity). Interacts with c-Met/MET, when c-Met/MET is phosphorylated on 'Tyr-1356' (By similarity). Interacts with p130Cas/BCAR1 (By similarity). Interacts with CENTD3/ARAP3 via its SAM domain (By similarity). Interacts with c-Cbl/CBL and CAP/SORBS1 (By similarity). Interacts with activated EPHA2 receptor (PubMed:29749928). Interacts with receptors FCGR2A (By similarity). Interacts with FCGR2B (PubMed:10789675, PubMed:15456754). Interacts with tyrosine kinase ABL1 (By similarity). Interacts with tyrosine kinase TEC (PubMed:15492005). Interacts with CSF1R (PubMed:15557176). Interacts (via N-terminus) with SH3YL1 (via SH3 domain) (PubMed:21624956). Interacts (via SH2 domain) with tyrosine phosphorylated KLRC1 (via ITIM) (PubMed:9485206). Interacts with NEDD9/HEF1 (By similarity). Q6P549; Q9Z0R4-2: Itsn1; NbExp=2; IntAct=EBI-2642932, EBI-8052786; Cytoplasm, cytosol Cytoplasm, cytoskeleton Membrane ; Peripheral membrane protein. Cell projection, filopodium Cell projection, lamellipodium Basal cell membrane Nucleus Nucleus speckle Cytoplasm, cytoskeleton, spindle pole Note=Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B). Tyrosine phosphorylation may also participate in membrane localization. Insulin specifically stimulates its redistribution from the cytosol to the plasma membrane. Recruited to the membrane following M-CSF stimulation. In activated spreading platelets, localizes with actin at filopodia, lamellipodia and the central actin ring. Widely expressed. In 15.5 dpc embryos, it is strongly expressed in the liver, specific regions of the central nervous system, the thymus, the lung, and the cartilage perichondrium. In adult it is markedly present in the brain and the thymus and at different stages of spermatozoa maturation in the seminiferous tubules. Overexpressed in diabetic db/db mice. The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or FCGR2A (By similarity). It also mediates the interaction with p130Cas/BCAR1 (By similarity). The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as insulin, growth factors such as EGF or PDGF, chemokines, integrin ligands and hypertonic and oxidative stress. May be phosphorylated upon IgG receptor FCGR2B-binding. Phosphorylated at Tyr-987 following cell attachment and spreading. Phosphorylated at Tyr-1161 following EGF signaling pathway stimulation (By similarity). Mice are viable, have normal glucose and insulin levels, and normal insulin and glucose tolerance. They are however highly resistant to weight gain when placed on a high-fat diet, suggesting that inhibition of Inppl1 would be useful in the effort to ameliorate diet-induced obesity. According to preliminary results from PubMed:11343120, mice display increased sensitivity to insulin, characterized by severe neonatal hypoglycemia, deregulated expression of the genes involved in gluconeogenesis, and perinatal death. They display increased glucose tolerance and insulin sensitivity associated with an increased recruitment of the Slc2a4/Glut4 glucose transporter and increased glycogen synthesis in skeletal muscles. However, these knockout mice also contain a deletion of the last exon of Phox2a gene. It is therefore unknown whether the insulin sensitivity observed in these mice result from inactivation of either Inppl1 or Phox2a. Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. Sequence=AAI19454.1; Type=Erroneous initiation; Evidence=; endochondral ossification immune system process actin binding inositol-polyphosphate 5-phosphatase activity protein binding phosphatidylinositol-3,4,5-trisphosphate binding nucleus cytoplasm Golgi apparatus cytosol cytoskeleton plasma membrane glucose metabolic process phosphatidylinositol biosynthetic process endocytosis actin filament organization cell adhesion negative regulation of DNA replication negative regulation of cell proliferation post-embryonic development negative regulation of gene expression negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of neuron projection development membrane nuclear speck hydrolase activity SH3 domain binding lamellipodium filopodium response to insulin inositol trisphosphate metabolic process SH2 domain binding cell projection negative regulation of MAP kinase activity negative regulation of insulin-like growth factor receptor signaling pathway cellular lipid metabolic process negative regulation of insulin receptor signaling pathway phosphatidylinositol dephosphorylation ruffle assembly uc009iph.1 uc009iph.2 uc009iph.3 uc009iph.4 
ENSMUST00000035840.6 Zdhhc5 ENSMUST00000035840.6 zinc finger, DHHC domain containing 5 (from RefSeq NM_144887.4) ENSMUST00000035840.1 ENSMUST00000035840.2 ENSMUST00000035840.3 ENSMUST00000035840.4 ENSMUST00000035840.5 Kiaa1748 NM_144887 Q2TGE8 Q69ZB5 Q8R2X7 Q8VDZ4 ZDHC5_MOUSE uc008kiz.1 uc008kiz.2 uc008kiz.3 uc008kiz.4 Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:22081607). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:24562000). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins. Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2. Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2. Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes. Participates also in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:30605677). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis. Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (PubMed:34724258). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence= Q8VDZ4; Q9D428: GOLGA7B; NbExp=2; IntAct=EBI-7057556, EBI-25635843; Cell membrane ulti-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VDZ4-1; Sequence=Displayed; Name=2; IsoId=Q8VDZ4-2; Sequence=VSP_006936, VSP_006937; Highly enriched in brain, detectable in liver and heart, and undetectable in most other tissues. In neural stem cells, rapid up-regulation by EGF, combined with FGF2 and heparin. The DHHC domain is required for palmitoyltransferase activity. Phosphorylation regulates association with endocytic proteins and its subcellular localization. Phosphorylation by LYN during fatty acid uptake leads to inactivation of the activity. Autopalmitoylated (By similarity). Palmitoylation of the C- terminal tail regulates stimulation-dependent plasma membrane motility (By similarity). Deletion mutant mice are born at half the expected rate, and survivors show a marked deficit in contextual fear conditioning, an indicator of defective hippocampal-dependent learning (PubMed:20178993). Loss of ZDHHC5 in oligodendrocytes inhibits myelination and reduces the expression levels of myelin-related and anti-apoptosis genes (PubMed:34724258). In neural stem cells, rapidly degraded through the proteasome pathway following growth factors withdrawal, a strategy used to induce differentiation. Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. Sequence=BAD32529.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding plasma membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups protein palmitoylation protein-cysteine S-palmitoyltransferase activity dendrite uc008kiz.1 uc008kiz.2 uc008kiz.3 uc008kiz.4 
ENSMUST00000035842.7 Rassf4 ENSMUST00000035842.7 Ras association (RalGDS/AF-6) domain family member 4 (from RefSeq NM_178045.4) ENSMUST00000035842.1 ENSMUST00000035842.2 ENSMUST00000035842.3 ENSMUST00000035842.4 ENSMUST00000035842.5 ENSMUST00000035842.6 NM_178045 Q3TBK1 Q3TPH9 Q3TUT0 Q6P9L7 Q8CB96 Q8CIM6 RASF4_MOUSE uc009dkm.1 uc009dkm.2 uc009dkm.3 uc009dkm.4 Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest. Interacts directly with activated KRAS in a GTP-dependent manner. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CB96-1; Sequence=Displayed; Name=2; IsoId=Q8CB96-2; Sequence=VSP_019362; Name=3; IsoId=Q8CB96-3; Sequence=VSP_019360, VSP_019361; Sequence=BAE42308.1; Type=Frameshift; Evidence=; molecular_function cellular_component cell cycle signal transduction uc009dkm.1 uc009dkm.2 uc009dkm.3 uc009dkm.4 
ENSMUST00000035844.11 Josd2 ENSMUST00000035844.11 Josephin domain containing 2, transcript variant 7 (from RefSeq NR_153758.1) ENSMUST00000035844.1 ENSMUST00000035844.10 ENSMUST00000035844.2 ENSMUST00000035844.3 ENSMUST00000035844.4 ENSMUST00000035844.5 ENSMUST00000035844.6 ENSMUST00000035844.7 ENSMUST00000035844.8 ENSMUST00000035844.9 JOS2_MOUSE NR_153758 Q9CR30 uc009gpl.1 uc009gpl.2 uc009gpl.3 uc009gpl.4 Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Cytoplasm, cytosol thiol-dependent ubiquitin-specific protease activity cellular_component cytoplasm cytosol proteolysis peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity uc009gpl.1 uc009gpl.2 uc009gpl.3 uc009gpl.4 
ENSMUST00000035849.5 Cfap95 ENSMUST00000035849.5 cilia and flagella associated protein 95 (from RefSeq NM_026188.2) CFA95_MOUSE Cfap95 ENSMUST00000035849.1 ENSMUST00000035849.2 ENSMUST00000035849.3 ENSMUST00000035849.4 NM_026188 Q9CQC3 uc008had.1 uc008had.2 uc008had.3 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Interacts with MYH9. Interacts with MYH10. Cytoplasm, cytoskeleton, cilium axoneme Cell membrane ; Single-pass membrane protein Cytoplasm Highly expressed in the testis. Weakly or not expressed in embryonic stem cells. molecular_function cytoplasm plasma membrane biological_process membrane integral component of membrane uc008had.1 uc008had.2 uc008had.3 
ENSMUST00000035850.8 Npat ENSMUST00000035850.8 nuclear protein in the AT region, transcript variant 2 (from RefSeq NM_001409956.1) ENSMUST00000035850.1 ENSMUST00000035850.2 ENSMUST00000035850.3 ENSMUST00000035850.4 ENSMUST00000035850.5 ENSMUST00000035850.6 ENSMUST00000035850.7 NM_001409956 NPAT_MOUSE Q8BMA5 Q8BWA9 Q8BY06 uc009pmf.1 uc009pmf.2 uc009pmf.3 Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters (By similarity). Required for early embryonic development. Interacts with the cylin/CDK complexes CCNE1/CDK2 and CCNA1/CDK2. Interacts with BZW1, CASP8AP2, CREBBP, MIZF and YY1. Interacts with the RUVBL1, RUVBL2 and TRRAP subunits of the NuA4 complex. May also interact with GAPDH, NME1, NME2 and STIP1 (By similarity). Nucleus Note=Concentrates in Cajal bodies tethered to histone gene clusters. Expression peaks at the G1/S phase boundary. The LisH domain is required for the activation of histone gene transcription. Phosphorylated at Ser-771, Ser-773, Ser-1096, Thr-1264 and Thr- 1343 by CCNE1/CDK2 at G1-S transition and until prophase, which promotes association with histone gene clusters and stimulates activation of histone transcription. Also phosphorylated by CCNA1/CDK2 in vitro (By similarity). Belongs to the NPAT family. regulation of transcription involved in G1/S transition of mitotic cell cycle in utero embryonic development transcription cofactor activity transcription coactivator activity transcription corepressor activity nucleus nucleoplasm cytoplasm cell cycle protein C-terminus binding regulation of gene expression Cajal body positive regulation of transcription, DNA-templated protein N-terminus binding Gemini of coiled bodies negative regulation of nucleic acid-templated transcription uc009pmf.1 uc009pmf.2 uc009pmf.3 
ENSMUST00000035852.14 Zcwpw1 ENSMUST00000035852.14 zinc finger, CW type with PWWP domain 1, transcript variant 1 (from RefSeq NM_001360023.1) ENSMUST00000035852.1 ENSMUST00000035852.10 ENSMUST00000035852.11 ENSMUST00000035852.12 ENSMUST00000035852.13 ENSMUST00000035852.2 ENSMUST00000035852.3 ENSMUST00000035852.4 ENSMUST00000035852.5 ENSMUST00000035852.6 ENSMUST00000035852.7 ENSMUST00000035852.8 ENSMUST00000035852.9 Gm1053 NM_001360023 Q2YFS4 Q6IR42 ZCPW1_MOUSE uc009adz.1 uc009adz.2 uc009adz.3 uc009adz.4 Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3) that facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs) (PubMed:32374261, PubMed:32352380, PubMed:32744506). Essential for male fertility and spermatogenesis (PubMed:31453335, PubMed:32374261, PubMed:32352380, PubMed:32744506). Required for meiosis prophase I progression in male but not in female germ cells (PubMed:31453335). Nucleus romosome Testis (at protein level) (PubMed:31453335, PubMed:32352380, PubMed:32374261, PubMed:32744506). Expressed in thymus, brain, lung, ovary, oviduct and uterus (PubMed:31453335). The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3. Male mice are sterile with complete azoospermia and reduced testis size, show impaired spermatogenesis, spermatocytes display meiotic arrest at around the zygotene to pachytene stage with incomplete homologous synapsis which is accompanied by defective DNA double-strand breaks repair (PubMed:31453335, PubMed:32374261, PubMed:32352380, PubMed:32744506). Fertility of females is normal up to mid-adulthood (5 to 6 months of age), at 3 and 6 months, ovaries exhibit healthy ovarian morphologies, however ovaries are devoid of follicles at around 8 months of age, and accordingly female mice become infertile (PubMed:31453335, PubMed:32744506). Female germ cells exhibit a successful but delayed meiosis prophase I progression (PubMed:31453335). molecular_function cellular_component biological_process zinc ion binding metal ion binding uc009adz.1 uc009adz.2 uc009adz.3 uc009adz.4 
ENSMUST00000035854.4 Cdrt4 ENSMUST00000035854.4 CMT1A duplicated region transcript 4 (from RefSeq NM_025496.1) CDRT4_MOUSE ENSMUST00000035854.1 ENSMUST00000035854.2 ENSMUST00000035854.3 NM_025496 Q9D9Y3 Q9DA64 uc007jkj.1 uc007jkj.2 molecular_function cellular_component biological_process uc007jkj.1 uc007jkj.2 
ENSMUST00000035870.5 Fancd2os ENSMUST00000035870.5 Fancd2 opposite strand (from RefSeq NM_027633.3) A0A0R4J1W5 A0A0R4J1W5_MOUSE ENSMUST00000035870.1 ENSMUST00000035870.2 ENSMUST00000035870.3 ENSMUST00000035870.4 Fancd2os NM_027633 uc009dgy.1 uc009dgy.2 uc009dgy.3 uc009dgy.1 uc009dgy.2 uc009dgy.3 
ENSMUST00000035871.15 Tmem127 ENSMUST00000035871.15 transmembrane protein 127, transcript variant 1 (from RefSeq NM_175145.4) A2ARF9 ENSMUST00000035871.1 ENSMUST00000035871.10 ENSMUST00000035871.11 ENSMUST00000035871.12 ENSMUST00000035871.13 ENSMUST00000035871.14 ENSMUST00000035871.2 ENSMUST00000035871.3 ENSMUST00000035871.4 ENSMUST00000035871.5 ENSMUST00000035871.6 ENSMUST00000035871.7 ENSMUST00000035871.8 ENSMUST00000035871.9 NM_175145 Q3TMK7 Q8BGP5 TM127_MOUSE uc008mfc.1 uc008mfc.2 uc008mfc.3 Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor. Cell membrane ; Multi-pass membrane protein Cytoplasm Note=Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes. Belongs to the TMEM127 family. cytoplasm early endosome plasma membrane endosome organization negative regulation of cell proliferation membrane integral component of membrane Rab GTPase binding regulation of TOR signaling negative regulation of TOR signaling uc008mfc.1 uc008mfc.2 uc008mfc.3 
ENSMUST00000035890.8 Slc7a13 ENSMUST00000035890.8 solute carrier family 7, (cationic amino acid transporter, y+ system) member 13 (from RefSeq NM_028746.3) Agt1 ENSMUST00000035890.1 ENSMUST00000035890.2 ENSMUST00000035890.3 ENSMUST00000035890.4 ENSMUST00000035890.5 ENSMUST00000035890.6 ENSMUST00000035890.7 NM_028746 Q91WN3 S7A13_MOUSE Slc7a13 Xat2 uc012dau.1 uc012dau.2 uc012dau.3 Associates with SLC3A1/rBAT to form a functional heterodimeric complex that transports anionic and neutral amino acids across the apical plasma membrane of renal epithelium. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. May act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate. Reaction=L-aspartate(in) + L-cystine(out) = L-aspartate(out) + L- cystine(in); Xref=Rhea:RHEA:76299, ChEBI:CHEBI:29991, ChEBI:CHEBI:35491; Evidence=; Reaction=L-cystine(out) = L-cystine(in); Xref=Rhea:RHEA:76303, ChEBI:CHEBI:35491; Evidence=; Reaction=L-aspartate(in) + L-glutamate(out) = L-aspartate(out) + L- glutamate(in); Xref=Rhea:RHEA:76307, ChEBI:CHEBI:29985, ChEBI:CHEBI:29991; Evidence=; Reaction=L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L- glutamine(in); Xref=Rhea:RHEA:76311, ChEBI:CHEBI:29991, ChEBI:CHEBI:58359; Evidence=; Reaction=L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L- methionine(in); Xref=Rhea:RHEA:76315, ChEBI:CHEBI:29991, ChEBI:CHEBI:57844; Evidence=; Reaction=L-aspartate(in) + L-leucine(out) = L-aspartate(out) + L- leucine(in); Xref=Rhea:RHEA:76319, ChEBI:CHEBI:29991, ChEBI:CHEBI:57427; Evidence=; Reaction=L-aspartate(in) + L-valine(out) = L-aspartate(out) + L- valine(in); Xref=Rhea:RHEA:76323, ChEBI:CHEBI:29991, ChEBI:CHEBI:57762; Evidence=; Reaction=L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L- phenylalanine(in); Xref=Rhea:RHEA:76327, ChEBI:CHEBI:29991, ChEBI:CHEBI:58095; Evidence=; Reaction=L-aspartate(in) + L-tyrosine(out) = L-aspartate(out) + L- tyrosine(in); Xref=Rhea:RHEA:76331, ChEBI:CHEBI:29991, ChEBI:CHEBI:58315; Evidence=; Reaction=L-aspartate(in) + L-tryptophan(out) = L-aspartate(out) + L- tryptophan(in); Xref=Rhea:RHEA:76335, ChEBI:CHEBI:29991, ChEBI:CHEBI:57912; Evidence=; Kinetic parameters: KM=67.6 uM for L-cystine (uniport) ; Disulfide-linked heterodimer composed of the catalytic light subunit SLC7A13 and the heavy subunit SLC3A1. Apical cell membrane ; Multi-pass membrane protein Expressed in renal tubules in the outer stripe of the outer medulla and medullary ray (at protein level). Detected in male but not in female kidney. Belongs to the amino acid-polyamine-organocation (APC) superfamily. amino acid transport L-amino acid transmembrane transporter activity membrane integral component of membrane transmembrane transporter activity transmembrane transport L-alpha-amino acid transmembrane transport uc012dau.1 uc012dau.2 uc012dau.3 
ENSMUST00000035899.8 Bloc1s5 ENSMUST00000035899.8 biogenesis of lysosomal organelles complex-1, subunit 5, muted (from RefSeq NM_139063.3) BL1S5_MOUSE ENSMUST00000035899.1 ENSMUST00000035899.2 ENSMUST00000035899.3 ENSMUST00000035899.4 ENSMUST00000035899.5 ENSMUST00000035899.6 ENSMUST00000035899.7 Mu Muted NM_139063 Q3TCP2 Q8CAC9 Q8R015 uc007qdu.1 uc007qdu.2 uc007qdu.3 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8 (By similarity). Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. Interacts with BLOC1S4, BLOC1S6, DTNBP1/BLOC1S7 and PI4K2A. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R015-1; Sequence=Displayed; Name=2; IsoId=Q8R015-2; Sequence=VSP_008196; Detected in heart, brain, spleen, lung, kidney and testis. Note=Defects in Muted are the cause of the Muted (mu) mutant, which is characterized by light eyes at birth, hypopigmentation of the coat, platelet storage pool deficiency and lysosomal hyposecretion. Belongs to the BLOC1S5 family. protein binding anterograde axonal transport vesicle-mediated transport transport vesicle BLOC-1 complex neuron projection development melanosome transport otolith morphogenesis endosome to melanosome transport developmental pigmentation anterograde synaptic vesicle transport positive regulation of pigment cell differentiation axon cytoplasm uc007qdu.1 uc007qdu.2 uc007qdu.3 
ENSMUST00000035918.8 Cyp3a11 ENSMUST00000035918.8 cytochrome P450, family 3, subfamily a, polypeptide 11 (from RefSeq NM_007818.3) CP3AB_MOUSE Cyp3a-11 ENSMUST00000035918.1 ENSMUST00000035918.2 ENSMUST00000035918.3 ENSMUST00000035918.4 ENSMUST00000035918.5 ENSMUST00000035918.6 ENSMUST00000035918.7 NM_007818 Q64459 uc009amy.1 uc009amy.2 uc009amy.3 Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Highly expressed in liver. By dexamethasone. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane steroid metabolic process steroid hydroxylase activity retinoic acid 4-hydroxylase activity response to bacterium membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding organelle membrane demethylase activity intracellular membrane-bounded organelle metal ion binding testosterone 6-beta-hydroxylase activity oxidation-reduction process aromatase activity oxidative demethylation estrogen 16-alpha-hydroxylase activity uc009amy.1 uc009amy.2 uc009amy.3 
ENSMUST00000035925.7 Slc7a6os ENSMUST00000035925.7 solute carrier family 7, member 6 opposite strand, transcript variant 2 (from RefSeq NR_152744.1) ENSMUST00000035925.1 ENSMUST00000035925.2 ENSMUST00000035925.3 ENSMUST00000035925.4 ENSMUST00000035925.5 ENSMUST00000035925.6 NR_152744 Q7TPE5 S7A6O_MOUSE uc009nfp.1 uc009nfp.2 uc009nfp.3 uc009nfp.4 Directs RNA polymerase II nuclear import. Cytoplasm Nucleus Belongs to the IWR1/SLC7A6OS family. hematopoietic progenitor cell differentiation molecular_function cellular_component nucleus cytoplasm protein transport developmental process uc009nfp.1 uc009nfp.2 uc009nfp.3 uc009nfp.4 
ENSMUST00000035929.11 Aspdh ENSMUST00000035929.11 aspartate dehydrogenase domain containing (from RefSeq NM_026690.1) ASPDH_MOUSE Aspdh ENSMUST00000035929.1 ENSMUST00000035929.10 ENSMUST00000035929.2 ENSMUST00000035929.3 ENSMUST00000035929.4 ENSMUST00000035929.5 ENSMUST00000035929.6 ENSMUST00000035929.7 ENSMUST00000035929.8 ENSMUST00000035929.9 NM_026690 Q8VCQ0 Q9DCQ2 uc009gpk.1 uc009gpk.2 uc009gpk.3 Belongs to the L-aspartate dehydrogenase family. cellular_component NAD biosynthetic process oxidoreductase activity pyridine nucleotide biosynthetic process aspartate dehydrogenase activity NADP binding oxidation-reduction process uc009gpk.1 uc009gpk.2 uc009gpk.3 
ENSMUST00000035930.11 Zfp800 ENSMUST00000035930.11 zinc finger protein 800, transcript variant 3 (from RefSeq NM_001364596.2) ENSMUST00000035930.1 ENSMUST00000035930.10 ENSMUST00000035930.2 ENSMUST00000035930.3 ENSMUST00000035930.4 ENSMUST00000035930.5 ENSMUST00000035930.6 ENSMUST00000035930.7 ENSMUST00000035930.8 ENSMUST00000035930.9 NM_001364596 Q0VEE6 ZN800_MOUSE Znf800 uc009bcn.1 uc009bcn.2 uc009bcn.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus biological_process metal ion binding uc009bcn.1 uc009bcn.2 uc009bcn.3 
ENSMUST00000035931.13 Pcdh18 ENSMUST00000035931.13 protocadherin 18, transcript variant 1 (from RefSeq NM_130448.4) ENSMUST00000035931.1 ENSMUST00000035931.10 ENSMUST00000035931.11 ENSMUST00000035931.12 ENSMUST00000035931.2 ENSMUST00000035931.3 ENSMUST00000035931.4 ENSMUST00000035931.5 ENSMUST00000035931.6 ENSMUST00000035931.7 ENSMUST00000035931.8 ENSMUST00000035931.9 Kiaa1562 NM_130448 PCD18_MOUSE Q69ZG2 Q80VY4 Q8CB88 Q8VHR0 uc012cph.1 uc012cph.2 Potential calcium-dependent cell-adhesion protein. Interacts with DAB1. Q8VHR0; P97318: Dab1; NbExp=2; IntAct=EBI-399910, EBI-81680; Cell membrane ; Single-pass type I membrane protein Predominantly expressed in kidney and lung. Expressed at high levels throughout the developing embryo, except in the heart and liver. In the developing brain, expressed at high levels in the ventricular zone (vz) in the forebrain and midbrain. Expression in the developing brain is maximal around birth and gradually decreases until it is completely absent from the adult brain. Sequence=BAD32482.1; Type=Erroneous initiation; Evidence=; calcium ion binding protein binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules nervous system development brain development membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules uc012cph.1 uc012cph.2 
ENSMUST00000035934.7 Exoc3 ENSMUST00000035934.7 exocyst complex component 3 (from RefSeq NM_177333.4) ENSMUST00000035934.1 ENSMUST00000035934.2 ENSMUST00000035934.3 ENSMUST00000035934.4 ENSMUST00000035934.5 ENSMUST00000035934.6 Exoc3 NM_177333 Q8K0E2 Q8K0E2_MOUSE Sec6l1 uc007reu.1 uc007reu.2 uc007reu.3 Belongs to the SEC6 family. exocyst exocytosis presynaptic membrane uc007reu.1 uc007reu.2 uc007reu.3 
ENSMUST00000035938.3 Ccl5 ENSMUST00000035938.3 C-C motif chemokine ligand 5 (from RefSeq NM_013653.3) Ccl5 ENSMUST00000035938.1 ENSMUST00000035938.2 NM_013653 Q5XZF2 Q5XZF2_MOUSE uc007kpi.1 uc007kpi.2 uc007kpi.3 uc007kpi.4 Secreted Belongs to the intercrine beta (chemokine CC) family. MAPK cascade phosphatidylinositol phospholipase C activity protein kinase activity cytokine activity extracellular region extracellular space cell calcium ion transport cellular calcium ion homeostasis exocytosis chemotaxis inflammatory response immune response leukocyte cell-cell adhesion G-protein coupled receptor signaling pathway cell-cell signaling chemokine activity response to toxic substance positive regulation of macrophage chemotaxis positive regulation of T cell chemotaxis positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of smooth muscle cell migration phospholipase activator activity receptor signaling protein tyrosine kinase activator activity positive regulation of cell migration positive regulation of cellular biosynthetic process activation of phospholipase D activity lipopolysaccharide-mediated signaling pathway CCR1 chemokine receptor binding CCR5 chemokine receptor binding positive regulation of cell-cell adhesion mediated by integrin positive regulation of homotypic cell-cell adhesion chemoattractant activity positive regulation of T cell proliferation neutrophil activation positive regulation of phosphorylation chemokine receptor binding positive regulation of tyrosine phosphorylation of STAT protein identical protein binding protein homodimerization activity protein kinase B signaling protein self-association negative regulation by host of viral transcription cellular response to fibroblast growth factor stimulus negative regulation of viral genome replication negative regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell adhesion chemokine receptor antagonist activity eosinophil chemotaxis positive regulation of smooth muscle cell proliferation regulation of insulin secretion regulation of T cell activation positive chemotaxis positive regulation of calcium ion transport positive regulation of protein tyrosine kinase activity chemokine-mediated signaling pathway negative regulation of chemokine-mediated signaling pathway negative regulation of T cell apoptotic process positive regulation of T cell apoptotic process cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to organic cyclic compound positive regulation of monocyte chemotaxis regulation of neuron death positive regulation of T cell migration positive regulation of natural killer cell chemotaxis uc007kpi.1 uc007kpi.2 uc007kpi.3 uc007kpi.4 
ENSMUST00000035952.5 Ngf ENSMUST00000035952.5 nerve growth factor, transcript variant 2 (from RefSeq NM_001112698.2) ENSMUST00000035952.1 ENSMUST00000035952.2 ENSMUST00000035952.3 ENSMUST00000035952.4 NGF_MOUSE NM_001112698 Ngfb P01139 Q63864 Q6LDB7 uc012cuz.1 uc012cuz.2 uc012cuz.3 uc012cuz.4 Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:20036257). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:22649032). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse (PubMed:22155786). In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (PubMed:20036257). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer (PubMed:22649032, PubMed:26144237). The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (PubMed:22649032). Homodimer (PubMed:1956407, PubMed:8201620, PubMed:20036257, PubMed:22649032, PubMed:26144237, PubMed:30061605). The homodimer interacts with a single NTRK1 chain (PubMed:22649032). The homodimer interacts with a single NGFR chain (By similarity). The NGF dimer interacts with a single SORCS2 chain (via extracellular domain) (PubMed:30061605). The NGF precursor (proNGF) binds to a receptor complex formed by SORT1 and NGFR, which leads to NGF endocytosis (PubMed:20036257). Both mature NGF and the immature NGF precursor (proNGF) interact with SORCS2 and with the heterodimer formed by SORCS2 and NGFR (via extracellular domains) (PubMed:22155786, PubMed:30061605). The NGF precursor (proNGF) has much higher affinity for SORCS2 than mature NGF (PubMed:24908487). The NGF precursor (proNGF) has much higher affinity for SORT1 than mature NGF (PubMed:20036257). Interacts with ADAM10 in a divalent cation-dependent manner (By similarity). Secreted Endosome lumen Note=ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR. Detected in submaxillary gland (at protein level) (PubMed:1284621). Highly expressed in male submaxillary gland. Levels are much lower in female submaxillary gland (PubMed:6336309, PubMed:1284621). Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain. Belongs to the NGF-beta family. Sequence=AAA37687.1; Type=Erroneous initiation; Evidence=; Sequence=AAA39818.1; Type=Erroneous initiation; Evidence=; Sequence=AAA39820.1; Type=Erroneous initiation; Evidence=; Sequence=AAA39821.1; Type=Erroneous initiation; Evidence=; Sequence=CAA24221.1; Type=Erroneous initiation; Evidence=; positive regulation of protein phosphorylation enzyme inhibitor activity receptor binding nerve growth factor receptor binding extracellular region extracellular space endosome endoplasmic reticulum lumen activation of cysteine-type endopeptidase activity involved in apoptotic process transmembrane receptor protein tyrosine kinase signaling pathway activation of transmembrane receptor protein tyrosine kinase activity peripheral nervous system development memory circadian rhythm synaptic vesicle growth factor activity metalloendopeptidase inhibitor activity positive regulation of cell proliferation lipid binding adult locomotory behavior extrinsic apoptotic signaling pathway via death domain receptors cysteine-type endopeptidase activator activity involved in apoptotic process negative regulation of peptidase activity positive regulation of gene expression negative regulation of endopeptidase activity positive regulation of neuron projection development positive regulation of neuron maturation sensory perception of pain nerve development transmembrane receptor protein tyrosine kinase activator activity positive regulation of cell growth peptidase inhibitor activity axon dendrite neuron projection development positive regulation of protein ubiquitination cytoplasmic vesicle endosome lumen positive regulation of protein autophosphorylation positive regulation of protein binding death receptor agonist activity nerve growth factor signaling pathway positive regulation of DNA binding negative regulation of neuron apoptotic process neuron projection terminus regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of axon extension positive regulation of Ras protein signal transduction regulation of neurotransmitter secretion neuron development positive regulation of collateral sprouting neuron projection morphogenesis modulation of synaptic transmission positive regulation of sequence-specific DNA binding transcription factor activity regulation of release of sequestered calcium ion into cytosol positive regulation of neurotrophin TRK receptor signaling pathway neuron apoptotic process positive regulation of ERK1 and ERK2 cascade extrinsic apoptotic signaling pathway in absence of ligand positive regulation of stem cell proliferation negative regulation of type B pancreatic cell apoptotic process uc012cuz.1 uc012cuz.2 uc012cuz.3 uc012cuz.4 
ENSMUST00000035977.9 Ticrr ENSMUST00000035977.9 TOPBP1-interacting checkpoint and replication regulator (from RefSeq NM_029835.1) B2RY55 ENSMUST00000035977.1 ENSMUST00000035977.2 ENSMUST00000035977.3 ENSMUST00000035977.4 ENSMUST00000035977.5 ENSMUST00000035977.6 ENSMUST00000035977.7 ENSMUST00000035977.8 NM_029835 Q8BQ33 Q8C9N4 Q8CCI2 TICRR_MOUSE uc009hyp.1 uc009hyp.2 uc009hyp.3 Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre- replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation (By similarity). Interacts with TOPBP1 (via BRCT domains); interaction takes place in a CDK2-dependent manner (By similarity). Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR (By similarity). Nucleus Note=Associates with chromatin. Belongs to the treslin family. Sequence=AAH58634.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC28152.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC34701.1; Type=Frameshift; Evidence=; chromatin binding nucleus nucleoplasm DNA replication DNA repair cellular response to DNA damage stimulus cell cycle mitotic cell cycle checkpoint response to ionizing radiation regulation of DNA-dependent DNA replication initiation mitotic DNA replication checkpoint uc009hyp.1 uc009hyp.2 uc009hyp.3 
ENSMUST00000035980.9 Gm9758 ENSMUST00000035980.9 predicted gene 9758 (from RefSeq NM_198666.4) ENSMUST00000035980.1 ENSMUST00000035980.2 ENSMUST00000035980.3 ENSMUST00000035980.4 ENSMUST00000035980.5 ENSMUST00000035980.6 ENSMUST00000035980.7 ENSMUST00000035980.8 Gm9758 NM_198666 Q80ZT2 Q80ZT2_MOUSE uc008wmm.1 uc008wmm.2 uc008wmm.3 molecular_function cellular_component biological_process uc008wmm.1 uc008wmm.2 uc008wmm.3 
ENSMUST00000035983.12 Rpl21 ENSMUST00000035983.12 ribosomal protein L21, transcript variant 1 (from RefSeq NM_019647.7) ENSMUST00000035983.1 ENSMUST00000035983.10 ENSMUST00000035983.11 ENSMUST00000035983.2 ENSMUST00000035983.3 ENSMUST00000035983.4 ENSMUST00000035983.5 ENSMUST00000035983.6 ENSMUST00000035983.7 ENSMUST00000035983.8 ENSMUST00000035983.9 NM_019647 O09167 Q9CQM8 RL21_MOUSE Rpl21 uc009ank.1 uc009ank.2 uc009ank.3 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Cytoplasm, cytosol Cytoplasm Endoplasmic reticulum Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). Belongs to the eukaryotic ribosomal protein eL21 family. structural constituent of ribosome protein binding cytoplasm endoplasmic reticulum cytosol ribosome translation cytosolic large ribosomal subunit uc009ank.1 uc009ank.2 uc009ank.3 
ENSMUST00000035985.8 Fbxl18 ENSMUST00000035985.8 F-box and leucine-rich repeat protein 18 (from RefSeq NM_001033312.3) ENSMUST00000035985.1 ENSMUST00000035985.2 ENSMUST00000035985.3 ENSMUST00000035985.4 ENSMUST00000035985.5 ENSMUST00000035985.6 ENSMUST00000035985.7 F8VQK6 F8VQK6_MOUSE Fbxl18 NM_001033312 uc009aji.1 uc009aji.2 G2/M transition of mitotic cell cycle protein binding nucleus cytosol protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process regulation of cell cycle ubiquitin protein ligase activity uc009aji.1 uc009aji.2 
ENSMUST00000035987.9 Map3k9 ENSMUST00000035987.9 mitogen-activated protein kinase kinase kinase 9, transcript variant 2 (from RefSeq NM_177395.5) E9QLZ4 ENSMUST00000035987.1 ENSMUST00000035987.2 ENSMUST00000035987.3 ENSMUST00000035987.4 ENSMUST00000035987.5 ENSMUST00000035987.6 ENSMUST00000035987.7 ENSMUST00000035987.8 M3K9_MOUSE NM_177395 Q3U1V8 Q8BIG8 uc007oco.1 uc007oco.2 uc007oco.3 uc007oco.4 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Homodimerization via the leucine zipper domains is required for autophosphorylation of multiple sites in the activation loop and subsequent activation. Autophosphorylation at Thr-305 is the key step in activation of MAP3K9/MLK1 and is required for full phosphorylation. Autophosphorylation at Thr-297 and Ser-301 have been shown to be of secondary importance in the activation of MAP3K9/MLK1. Homodimer. Expressed in cochlea and utricle. Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-305 is likely to be the main autophosphorylation site (By similarity). Autophosphorylation also occurs on Thr-297 and Ser-301 (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. nucleotide binding activation of MAPKK activity protein kinase activity protein serine/threonine kinase activity JUN kinase kinase kinase activity MAP kinase kinase kinase activity ATP binding protein phosphorylation apoptotic process activation of JNKK activity activation of JUN kinase activity cell death kinase activity phosphorylation transferase activity positive regulation of apoptotic process protein autophosphorylation uc007oco.1 uc007oco.2 uc007oco.3 uc007oco.4 
ENSMUST00000035988.16 Txndc5 ENSMUST00000035988.16 thioredoxin domain containing 5, transcript variant 1 (from RefSeq NM_145367.4) ENSMUST00000035988.1 ENSMUST00000035988.10 ENSMUST00000035988.11 ENSMUST00000035988.12 ENSMUST00000035988.13 ENSMUST00000035988.14 ENSMUST00000035988.15 ENSMUST00000035988.2 ENSMUST00000035988.3 ENSMUST00000035988.4 ENSMUST00000035988.5 ENSMUST00000035988.6 ENSMUST00000035988.7 ENSMUST00000035988.8 ENSMUST00000035988.9 NM_145367 Q8R1I6 Q91W90 TXND5_MOUSE Tlp46 Txndc5 uc007qds.1 uc007qds.2 uc007qds.3 uc007qds.4 uc007qds.5 Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins (PubMed:12930873, PubMed:14971039). Can reduce insulin disulfide bonds (PubMed:14971039). Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; Evidence=; Endoplasmic reticulum lumen Expressed at high levels in plasma cells and at very low levels in all other cells and tissues examined (at protein level). Mass=51200; Method=MALDI; Evidence=; Belongs to the protein disulfide isomerase family. endoplasmic reticulum endoplasmic reticulum lumen isomerase activity apoptotic cell clearance cell redox homeostasis uc007qds.1 uc007qds.2 uc007qds.3 uc007qds.4 uc007qds.5 
ENSMUST00000035991.8 Bivm ENSMUST00000035991.8 basic, immunoglobulin-like variable motif containing, transcript variant 3 (from RefSeq NM_001357047.1) BIVM_MOUSE ENSMUST00000035991.1 ENSMUST00000035991.2 ENSMUST00000035991.3 ENSMUST00000035991.4 ENSMUST00000035991.5 ENSMUST00000035991.6 ENSMUST00000035991.7 NM_001357047 Q8CBX9 Q8CCP3 uc007awd.1 uc007awd.2 uc007awd.3 uc007awd.4 Cytoplasm Nucleus Belongs to the BIVM family. single-stranded DNA binding endodeoxyribonuclease activity nucleus cytoplasm nucleotide-excision repair, DNA incision, 3'-to lesion uc007awd.1 uc007awd.2 uc007awd.3 uc007awd.4 
ENSMUST00000036003.8 Klhl42 ENSMUST00000036003.8 kelch-like 42, transcript variant 3 (from RefSeq NM_001418233.1) ENSMUST00000036003.1 ENSMUST00000036003.2 ENSMUST00000036003.3 ENSMUST00000036003.4 ENSMUST00000036003.5 ENSMUST00000036003.6 ENSMUST00000036003.7 KLH42_MOUSE Kiaa1340 Klhdc5 NM_001418233 Q6ZPT4 Q8BFQ9 uc009esu.1 uc009esu.2 uc009esu.3 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis (By similarity). Protein modification; protein ubiquitination. Component of the BCR(KLHL42) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL42. Interacts (via the BTB domain) with CUL3. Interacts (via the kelch domains) with KATNA1 (By similarity). Cytoplasm Cytoplasm, cytoskeleton, spindle Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles (By similarity). During telophase is localized arround the nuclei of the two daughter cells. Not detected at the midbody region during cytokinesis. protein polyubiquitination ubiquitin-protein transferase activity cytoplasm spindle cytoskeleton cell cycle protein ubiquitination Cul3-RING ubiquitin ligase complex regulation of microtubule-based process proteasome-mediated ubiquitin-dependent protein catabolic process cell division uc009esu.1 uc009esu.2 uc009esu.3 
ENSMUST00000036016.6 Amh ENSMUST00000036016.6 anti-Mullerian hormone (from RefSeq NM_007445.3) A0A8Q0P8A2 A0A8Q0P8A2_MOUSE Amh ENSMUST00000036016.1 ENSMUST00000036016.2 ENSMUST00000036016.3 ENSMUST00000036016.4 ENSMUST00000036016.5 NM_007445 uc007get.1 uc007get.2 uc007get.3 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Homozygous knockout male mice develop female reproductive organs and are often sterile, while homozygous knockout female mice exhibit premature depletion of primordial follicles. [provided by RefSeq, Jul 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY911505.1, BC150477.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation and plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression. Homodimer; disulfide-linked. Secreted Belongs to the TGF-beta family. uc007get.1 uc007get.2 uc007get.3 
ENSMUST00000036018.6 Foxa3 ENSMUST00000036018.6 forkhead box A3 (from RefSeq NM_008260.2) ENSMUST00000036018.1 ENSMUST00000036018.2 ENSMUST00000036018.3 ENSMUST00000036018.4 ENSMUST00000036018.5 FOXA3_MOUSE Hnf3g NM_008260 P35584 Tcf-3g Tcf3g uc009fke.1 uc009fke.2 uc009fke.3 Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates GLUT2 transcription. Involved in regulation of neuronal-specific transcription. Involved in regulation of spermatogenesis; required for the maintenance of the testicular germ cell population and male fertility. Interacts with FOXA2. Nucleus. Restricted mainly to endoderm-derived tissues (lung, liver, stomach, and small intestine), also present additionally in ovary, testis, heart, and adipose tissue, but missing from lung. Expression peaks around day 15.5 of gestation. Expressed from day 6 to day 70 during postnatal testicular development. Reduced expression levels of several HNF3 target genes (phosphoenolpyruvate carboxykinase, transferrin, tyrosine aminotransferase) by 50 to 70%,. The germinal epithelium of testes is characterized by a loss of germ cells secondary to an increase in germ cell apoptosis that ultimately leads to a Sertoli cell-only syndrome. Significantly lower blood glucose in fasted mice. RNA polymerase II transcription factor activity, sequence-specific DNA binding cellular glucose homeostasis DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol chromatin organization regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development spermatogenesis transcription factor binding negative regulation of cell proliferation cellular response to starvation anatomical structure morphogenesis actin cytoskeleton protein domain specific binding cell differentiation endocrine pancreas development sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter positive regulation of hepatocyte differentiation uc009fke.1 uc009fke.2 uc009fke.3 
ENSMUST00000036019.5 Fras1 ENSMUST00000036019.5 Fraser extracellular matrix complex subunit 1 (from RefSeq NM_175473.3) E9QPG9 ENSMUST00000036019.1 ENSMUST00000036019.2 ENSMUST00000036019.3 ENSMUST00000036019.4 FRAS1_MOUSE Fras1 Kiaa1500 NM_175473 Q80T14 Q80TC7 Q811H8 Q8BPZ4 uc008yfk.1 uc008yfk.2 Involved in extracellular matrix organization (PubMed:32333816). Required for the regulation of epidermal-basement membrane adhesion responsible for proper organogenesis during embryonic development (PubMed:12766769). Involved in brain organization and function (PubMed:32333816). Q80T14; Q6NVD0: Frem2; NbExp=2; IntAct=EBI-15594303, EBI-15594269; Cell membrane ingle-pass type I membrane protein ; Extracellular side Highly expressed in the apical ectodermal ridge of the limb buds from 10.5-12.5 dpc and expression was also detected in the interdigital spaces at 14.5 dpc. Found in cells just underlying the surface epithelium of the entire embryo and in the linings of the peritoneal cavity and dorsal aorta. At 12 dpc, detected in the mesonephric duct and in the lens (PubMed:12766769). Found in a linear fashion underlying the epidermis and the basal surface of other epithelia in embryos (PubMed:12766770). Found in meningeal and choroidal epidermal-basement membranes in embryos and neonates (PubMed:32333816). The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding. Note=Defects in Fras1 are the cause of blebbed (bl) phenotype, which is characterized by blister formation, syndactyly, eyelid fusion and renal agenesis. Subepidermal blisters are predominantly formed in the head region around the eyes and at the distal part of the limbs. As development proceeds blisters that are initially transparent gradually become hemorrhagic and embryos die between 14.5 dpc and 16.5 dpc. Homozygous adult knockout mice display impaired performance in various types of learning and memory tasks as well as reduced anxiety. Belongs to the FRAS1 family. Sequence=BAC34788.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC34788.1; Type=Frameshift; Evidence=; morphogenesis of an epithelium metanephros morphogenesis extracellular matrix structural constituent protein binding basement membrane plasma membrane cell communication protein transport membrane integral component of membrane embryonic limb morphogenesis skin development metal ion binding palate development uc008yfk.1 uc008yfk.2 
ENSMUST00000036023.4 1700018B24Rik ENSMUST00000036023.4 RIKEN cDNA 1700018B24 gene (from RefSeq NR_003617.2) ENSMUST00000036023.1 ENSMUST00000036023.2 ENSMUST00000036023.3 NR_003617 uc008pde.1 uc008pde.2 uc008pde.3 uc008pde.4 uc008pde.5 uc008pde.6 uc008pde.7 uc008pde.1 uc008pde.2 uc008pde.3 uc008pde.4 uc008pde.5 uc008pde.6 uc008pde.7 
ENSMUST00000036025.16 Ccdc93 ENSMUST00000036025.16 coiled-coil domain containing 93, transcript variant 1 (from RefSeq NM_001025156.2) CCD93_MOUSE ENSMUST00000036025.1 ENSMUST00000036025.10 ENSMUST00000036025.11 ENSMUST00000036025.12 ENSMUST00000036025.13 ENSMUST00000036025.14 ENSMUST00000036025.15 ENSMUST00000036025.2 ENSMUST00000036025.3 ENSMUST00000036025.4 ENSMUST00000036025.5 ENSMUST00000036025.6 ENSMUST00000036025.7 ENSMUST00000036025.8 ENSMUST00000036025.9 NM_001025156 Q3TX53 Q7TQK5 uc007cju.1 uc007cju.2 uc007cju.3 uc007cju.4 Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C. Interacts with COMMD1, COMMD2 COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10, WASHC1. Interacts directly with WASHC2C. Interacts with CCDC93; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22 and CCDC93; in the complex interacts directly with CCDC22. Interacts with VPS35L; associates with the retriever complex. Interacts with SNX17 and SNX31. Early endosome Belongs to the CCDC93 family. molecular_function endosome early endosome Golgi to plasma membrane transport protein transport endocytic recycling intracellular membrane-bounded organelle retrograde transport, endosome to plasma membrane uc007cju.1 uc007cju.2 uc007cju.3 uc007cju.4 
ENSMUST00000036031.13 Gsap ENSMUST00000036031.13 gamma-secretase activating protein, transcript variant 1 (from RefSeq NM_175437.4) ENSMUST00000036031.1 ENSMUST00000036031.10 ENSMUST00000036031.11 ENSMUST00000036031.12 ENSMUST00000036031.2 ENSMUST00000036031.3 ENSMUST00000036031.4 ENSMUST00000036031.5 ENSMUST00000036031.6 ENSMUST00000036031.7 ENSMUST00000036031.8 ENSMUST00000036031.9 GSAP_MOUSE NM_175437 Pion Q3TCV3 Q3UV93 Q8BJR8 Q8BZR8 Q8R1Y4 uc008woj.1 uc008woj.2 uc008woj.3 Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma- cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. Interacts with APP; specifically interacts with the CTF-alpha product of APP. Interacts with the gamma-secretase complex (By similarity). Golgi apparatus, trans-Golgi network Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TCV3-1; Sequence=Displayed; Name=2; IsoId=Q3TCV3-2; Sequence=VSP_033777, VSP_033778; Name=3; IsoId=Q3TCV3-3; Sequence=VSP_033775, VSP_033776; The protein is first synthesized as a holoprotein form of 98 kDa and rapidly processed into the gamma-secretase-activating protein 16 kDa C-terminal form, which constitutes the predominant form. Belongs to the GSAP family. Sequence=AAH22737.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC28433.1; Type=Frameshift; Evidence=; beta-amyloid binding Golgi apparatus trans-Golgi network regulation of proteolysis positive regulation of beta-amyloid formation uc008woj.1 uc008woj.2 uc008woj.3 
ENSMUST00000036033.14 Dip2a ENSMUST00000036033.14 disco interacting protein 2 homolog A (from RefSeq NM_001081419.2) Dip2a ENSMUST00000036033.1 ENSMUST00000036033.10 ENSMUST00000036033.11 ENSMUST00000036033.12 ENSMUST00000036033.13 ENSMUST00000036033.2 ENSMUST00000036033.3 ENSMUST00000036033.4 ENSMUST00000036033.5 ENSMUST00000036033.6 ENSMUST00000036033.7 ENSMUST00000036033.8 ENSMUST00000036033.9 F8WI56 F8WI56_MOUSE NM_001081419 uc033fql.1 uc033fql.2 uc033fql.3 Belongs to the DIP2 family. catalytic activity cell surface negative regulation of gene expression regulation of apoptotic process uc033fql.1 uc033fql.2 uc033fql.3 
ENSMUST00000036041.15 Ap1g2 ENSMUST00000036041.15 adaptor protein complex AP-1, gamma 2 subunit, transcript variant 1 (from RefSeq NM_007455.5) AP1G2_MOUSE ENSMUST00000036041.1 ENSMUST00000036041.10 ENSMUST00000036041.11 ENSMUST00000036041.12 ENSMUST00000036041.13 ENSMUST00000036041.14 ENSMUST00000036041.2 ENSMUST00000036041.3 ENSMUST00000036041.4 ENSMUST00000036041.5 ENSMUST00000036041.6 ENSMUST00000036041.7 ENSMUST00000036041.8 ENSMUST00000036041.9 NM_007455 O88512 Q2YDV3 uc007tye.1 uc007tye.2 uc007tye.3 uc007tye.4 uc007tye.5 This gene encodes the gamma-2 subunit of the adaptor protein complex 1 (AP-1). AP-1 complex is a heterotetramer comprised of two heavy and one each of medium and small subunits. The encoded protein is a heavy subunit of AP-1 complex that regulates polarized sorting of cargo at the trans-Golgi network and endosomes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV). May interact with AP1S1/Sigma1A-adaptin and AP1S2/Sigma1B- adaptin (By similarity). Probably does not interact with APB1 (By similarity). Interacts (via GAE domain) with RABEP1, NECAP1, CLINT1 and AFTPH/aftiphilin (By similarity). Interacts with HBV major surface antigen L. Interacts with HBV core protein C in a ubiquitin-dependent manner. Binds ubiquitin. Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Note=Mainly localized to perinuclear vesicular structures. Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments. Colocalizes with HBV major surface antigen L to cis-Golgi-like structures. Widely expressed. Belongs to the adaptor complexes large subunit family. Golgi membrane protein binding endosome Golgi apparatus Golgi-associated vesicle trans-Golgi network intracellular protein transport endosome membrane protein transport membrane vesicle-mediated transport membrane coat AP-1 adaptor complex transport vesicle cytoplasmic vesicle membrane cytoplasmic vesicle uc007tye.1 uc007tye.2 uc007tye.3 uc007tye.4 uc007tye.5 
ENSMUST00000036044.9 Zfc3h1 ENSMUST00000036044.9 zinc finger, C3H1-type containing (from RefSeq NM_001033261.2) B2RT41 B2RT41_MOUSE Ccdc131 ENSMUST00000036044.1 ENSMUST00000036044.2 ENSMUST00000036044.3 ENSMUST00000036044.4 ENSMUST00000036044.5 ENSMUST00000036044.6 ENSMUST00000036044.7 ENSMUST00000036044.8 NM_001033261 Zfc3h1 uc007hbg.1 uc007hbg.2 uc007hbg.3 exosome (RNase complex) RNA binding nucleus RNA processing biological_process uc007hbg.1 uc007hbg.2 uc007hbg.3 
ENSMUST00000036045.6 Leap2 ENSMUST00000036045.6 liver-expressed antimicrobial peptide 2 (from RefSeq NM_153069.3) ENSMUST00000036045.1 ENSMUST00000036045.2 ENSMUST00000036045.3 ENSMUST00000036045.4 ENSMUST00000036045.5 LEAP2_MOUSE NM_153069 Q5EBH6 Q91V13 uc007ivx.1 uc007ivx.2 uc007ivx.3 Has an antimicrobial activity. Secreted. Belongs to the LEAP2 family. extracellular region defense response to bacterium defense response to fungus uc007ivx.1 uc007ivx.2 uc007ivx.3 
ENSMUST00000036049.6 Hsdl1 ENSMUST00000036049.6 hydroxysteroid dehydrogenase like 1, transcript variant 6 (from RefSeq NR_166414.1) ENSMUST00000036049.1 ENSMUST00000036049.2 ENSMUST00000036049.3 ENSMUST00000036049.4 ENSMUST00000036049.5 HSDL1_MOUSE NR_166414 Q3U839 Q8BTX9 uc009npv.1 uc009npv.2 uc009npv.3 uc009npv.4 Interacts with STYXL1. Mitochondrion Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. Although it belongs to the SDR family, Phe-218 is present instead of the conserved Tyr which is an active site residue. It is therefore expected that this protein lacks oxidoreductase activity. molecular_function mitochondrion biological_process oxidation-reduction process steroid dehydrogenase activity uc009npv.1 uc009npv.2 uc009npv.3 uc009npv.4 
ENSMUST00000036060.13 Isl1 ENSMUST00000036060.13 ISL1 transcription factor, LIM/homeodomain (from RefSeq NM_021459.4) ENSMUST00000036060.1 ENSMUST00000036060.10 ENSMUST00000036060.11 ENSMUST00000036060.12 ENSMUST00000036060.2 ENSMUST00000036060.3 ENSMUST00000036060.4 ENSMUST00000036060.5 ENSMUST00000036060.6 ENSMUST00000036060.7 ENSMUST00000036060.8 ENSMUST00000036060.9 ISL1_MOUSE NM_021459 P20663 P47894 P61372 Q812D8 uc007rye.1 uc007rye.2 uc007rye.3 uc007rye.4 DNA-binding transcriptional activator (PubMed:14664703, PubMed:24643061, PubMed:25775587, PubMed:22343712, PubMed:18539116). Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes (PubMed:24643061, PubMed:25775587, PubMed:18539116). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation (PubMed:25775587). Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina (PubMed:24643061, PubMed:25775587). Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (PubMed:18583962). Binds to insulin gene enhancer sequences (By similarity). Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (PubMed:14667410). At neuronal promoters, displaces LDB1 from LHX3 LIM domain to form a ternary complex in which ISL1 contacts both LHX3 and LDB1; allosteric structural changes in the DNA binding domain of LHX3, induced by the ISL1:LHX3 interaction, may explain differences in sequence specificity of the different complexes (PubMed:18583962, PubMed:18539116). Interacts with LHX3 (PubMed:18539116). Interacts (via C-terminus) with POU4F2 (via C-terminus) isoform 1 (PubMed:24643061). Interacts with POU3F2 (PubMed:24643061). Interacts with POU4F3 (PubMed:24643061). Interacts (via N-terminal domain) with MLIP; the interaction represses ISL1 transactivator activity (PubMed:22343712, PubMed:36112854). Interacts with GCN5/KAT2A. Interactions of ISL1 with MLIP1 or KAT2A may be mutually exclusive (PubMed:36112854). P61372; P70662: Ldb1; NbExp=4; IntAct=EBI-7988215, EBI-6272082; P61372; P50481: Lhx3; NbExp=7; IntAct=EBI-7988215, EBI-7988290; [Isoform 1]: Nucleus [Isoform 2]: Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Isl1-alpha ; IsoId=P61372-1; Sequence=Displayed; Name=2; Synonyms=Isl1-beta ; IsoId=P61372-2; Sequence=VSP_010338; Between 7.5 dpc and 8.5 dpc, as the heart tube forms, expressed in splanchnic mesenchyme comprising the mesocardium and adjacent to foregut endoderm as well as in both splanchnic mesoderm and in ventral foregut endoderm. At 10 dpc, continues to be expressed in ventral endoderm and splanchnic mesoderm but is not expressed in the myocardium of the heart (PubMed:14667410). At 10.5 dpc, expressed in cardiomyocytes located in the outflow tract (PubMed:22343712). Down-regulated by beta-catenin/CTNNB1 in mesenchymal stem cells (at protein level). The down-regulation probably proceeds through ubiquitination by WWP1 E3 ubiquitin ligase and protein degradation. Ubiquitinated probably by WWP1 E3 ubiquitin ligase; ubiquitination is followed by protein degradation. Isoform 1 is phosphorylated. Embryonic mutants exhibit growth retardation at approximately 9.5 dpc and die at approximately 10.5 dpc. Between 9.0 dpc and 9.5 dpc hearts are severely abnormal, appear misshapen and unlooped. Hearts are completely missing the outflow tract, right ventricle, and much of the atria (PubMed:14667410). Conditional mutants for retina expression show a decrease in several gene expression levels involved in the differentiation of retinal ganglion cells (RGC) (PubMed:24643061). [Isoform 2]: Preferentially expressed in insulinoma cell lines. Expression is much lower than that of isoform 1. Shows relatively higher transcriptional activity than isoform 1. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II activating transcription factor binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding neural crest cell migration heart morphogenesis secondary heart field specification outflow tract septum morphogenesis outflow tract morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis regulation of secondary heart field cardioblast proliferation DNA binding chromatin binding transcription coactivator activity protein binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development axonogenesis heart development positive regulation of cell proliferation regulation of gene expression positive regulation of vascular endothelial growth factor production positive regulation of epithelial to mesenchymal transition ligand-dependent nuclear receptor binding spinal cord motor neuron cell fate specification spinal cord motor neuron differentiation visceral motor neuron differentiation trigeminal nerve development pituitary gland development cell differentiation neuron differentiation estrogen receptor binding pancreas development axon regeneration retinal ganglion cell axon guidance positive regulation of insulin secretion positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-1 alpha production positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production negative regulation of intracellular estrogen receptor signaling pathway positive regulation of histone acetylation positive regulation of tyrosine phosphorylation of STAT protein positive regulation of DNA binding bHLH transcription factor binding negative regulation of neuron apoptotic process sequence-specific DNA binding positive regulation of cell differentiation negative regulation of neuron differentiation positive regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding neuron fate commitment neuron fate specification mesenchymal cell differentiation sensory system development peripheral nervous system neuron development peripheral nervous system neuron axonogenesis negative regulation of epithelial cell proliferation negative regulation of inflammatory response ventricular cardiac muscle tissue morphogenesis pharyngeal system development cardiac muscle cell myoblast differentiation innervation atrial septum morphogenesis cardiac cell fate determination cellular response to glucocorticoid stimulus positive regulation of granulocyte colony-stimulating factor production negative regulation of protein homodimerization activity negative regulation of canonical Wnt signaling pathway positive regulation of macrophage colony-stimulating factor production promoter-specific chromatin binding uc007rye.1 uc007rye.2 uc007rye.3 uc007rye.4 
ENSMUST00000036069.8 Mamdc2 ENSMUST00000036069.8 MAM domain containing 2 (from RefSeq NM_174857.3) A0A0R4J0J7 A0A0R4J0J7_MOUSE ENSMUST00000036069.1 ENSMUST00000036069.2 ENSMUST00000036069.3 ENSMUST00000036069.4 ENSMUST00000036069.5 ENSMUST00000036069.6 ENSMUST00000036069.7 Mamdc2 NM_174857 uc008hac.1 uc008hac.2 uc008hac.3 endoplasmic reticulum membrane uc008hac.1 uc008hac.2 uc008hac.3 
ENSMUST00000036070.15 Fam107a ENSMUST00000036070.15 family with sequence similarity 107, member A, transcript variant 2 (from RefSeq NM_183187.5) ENSMUST00000036070.1 ENSMUST00000036070.10 ENSMUST00000036070.11 ENSMUST00000036070.12 ENSMUST00000036070.13 ENSMUST00000036070.14 ENSMUST00000036070.2 ENSMUST00000036070.3 ENSMUST00000036070.4 ENSMUST00000036070.5 ENSMUST00000036070.6 ENSMUST00000036070.7 ENSMUST00000036070.8 ENSMUST00000036070.9 F107A_MOUSE Fam107a NM_183187 Q78TU8 uc007sfa.1 uc007sfa.2 uc007sfa.3 Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics (PubMed:21969592). Mediates polymerization of globular actin to F-actin (PubMed:21969592). Also binds to, stabilizes and bundles F-actin (PubMed:21969592). Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (PubMed:21969592). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development (By similarity). Interacts with ACTB (PubMed:21969592). Interacts with F-actin (PubMed:21969592). Interacts with PRDX1 (PubMed:21969592). Interacts with COMMD1; this interaction stabilizes COMMD1 in the nucleus (By similarity). Interacts with MAP1A (By similarity). Nucleus Cytoplasm, cytoskeleton, stress fiber Cell junction, focal adhesion Cell projection, ruffle membrane Synapse Note=Colocalizes with F-actin (PubMed:21969592). Colocalizes with F-actin and COMMD1 in the nucleus. Colocalizes with MAP1A along actin stress fibers and membrane ruffles (By similarity). Expressed in septum, the neocortex, the CA3 region of the hippocampus and the cerebellum (at protein level). Up-regulated in the hypothalamic paraventricular nucleus (PVN) and the CA3 region of the hippocampus of the brain in response to postnatal maternal separation or food deprivation and glucocorticoids stimulation in adult animals (PubMed:21969592). Up-regulated in CA1, CA3 and dente gyrus regions of the hippocampus in response to acute social defeat stress or glucocorticoids stimulation (PubMed:25637808). regulation of cell growth stress fiber actin binding protein binding nucleus cytoplasm cytoskeleton plasma membrane focal adhesion cell cycle actin cytoskeleton membrane nuclear speck actin filament polymerization cell junction positive regulation of cell migration positive regulation of protein ubiquitination regulation of protein stability cellular response to nutrient levels ruffle membrane regulation of actin cytoskeleton organization regulation of growth cell projection neuron projection synapse cognition actin filament bundle assembly negative regulation of focal adhesion assembly regulation of microtubule cytoskeleton organization cellular response to glucocorticoid stimulus negative regulation of long-term synaptic potentiation negative regulation of G1/S transition of mitotic cell cycle uc007sfa.1 uc007sfa.2 uc007sfa.3 
ENSMUST00000036072.8 Rubcnl ENSMUST00000036072.8 RUN and cysteine rich domain containing beclin 1 interacting protein like, transcript variant 1 (from RefSeq NM_198642.2) 5031414D18Rik ENSMUST00000036072.1 ENSMUST00000036072.2 ENSMUST00000036072.3 ENSMUST00000036072.4 ENSMUST00000036072.5 ENSMUST00000036072.6 ENSMUST00000036072.7 F8WGX2 F8WGX2_MOUSE NM_198642 Rubcnl uc007uqk.1 uc007uqk.2 autophagosome membrane phosphatidylinositol-5-phosphate binding phosphatidylinositol-3-phosphate binding phosphatidylinositol-4-phosphate binding autophagosome maturation uc007uqk.1 uc007uqk.2 
ENSMUST00000036089.8 Trim69 ENSMUST00000036089.8 tripartite motif-containing 69, transcript variant 4 (from RefSeq NR_166638.1) ENSMUST00000036089.1 ENSMUST00000036089.2 ENSMUST00000036089.3 ENSMUST00000036089.4 ENSMUST00000036089.5 ENSMUST00000036089.6 ENSMUST00000036089.7 NR_166638 Q80X56 Q8VHZ6 Rnf36 TRI69_MOUSE Trif uc008mah.1 uc008mah.2 E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Plays also a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination. Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homo-multimer; required for antiviral activity (By similarity). Interacts with PML (PubMed:12837286). Cytoplasm Nucleus Nucleus speckle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Adopts a filamentous distribution in the cell cytoplasm where it strongly colocalizes with stable microtubules. Expressed in spermatid. The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity and for nuclear localization and aggregation. Phosphorylated. Phosphorylation is necessary for nuclear localization. Male TRIM69-knockout mice have normal fertility. Appearance of testes, testis/body weight ratios, testicular histomorphology, and the number and quality of sperm are consistent with wild-type mice. Belongs to the TRIM/RBCC family. ubiquitin-protein transferase activity nucleus cytoplasm apoptotic process protein ubiquitination nuclear speck transferase activity metal ion binding uc008mah.1 uc008mah.2 
ENSMUST00000036092.10 Kcnh2 ENSMUST00000036092.10 potassium voltage-gated channel, subfamily H (eag-related), member 2, transcript variant 1 (from RefSeq NM_013569.2) ENSMUST00000036092.1 ENSMUST00000036092.2 ENSMUST00000036092.3 ENSMUST00000036092.4 ENSMUST00000036092.5 ENSMUST00000036092.6 ENSMUST00000036092.7 ENSMUST00000036092.8 ENSMUST00000036092.9 Kcnh2 NM_013569 Q53Z09 Q53Z09_MOUSE uc008wrc.1 uc008wrc.2 Membrane ; Multi- pass membrane protein Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily. ion channel activity inward rectifier potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex cell surface membrane integral component of membrane ubiquitin protein ligase binding regulation of ion transmembrane transport cellular response to drug regulation of membrane potential identical protein binding protein homodimerization activity perinuclear region of cytoplasm potassium ion homeostasis transmembrane transport C3HC4-type RING finger domain binding cardiac muscle contraction regulation of membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization potassium ion transmembrane transport ventricular cardiac muscle cell action potential membrane repolarization membrane depolarization during action potential membrane repolarization during action potential membrane repolarization during cardiac muscle cell action potential regulation of heart rate by cardiac conduction scaffold protein binding potassium ion export across plasma membrane membrane repolarization during ventricular cardiac muscle cell action potential regulation of potassium ion transmembrane transport negative regulation of potassium ion transmembrane transport positive regulation of potassium ion transmembrane transport voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization inward rectifier potassium channel complex negative regulation of potassium ion export across plasma membrane potassium ion import across plasma membrane uc008wrc.1 uc008wrc.2 
ENSMUST00000036109.8 Rflna ENSMUST00000036109.8 Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. (from UniProt Q7TS73) AK014112 Cfm2 ENSMUST00000036109.1 ENSMUST00000036109.2 ENSMUST00000036109.3 ENSMUST00000036109.4 ENSMUST00000036109.5 ENSMUST00000036109.6 ENSMUST00000036109.7 Fam101a Q7TS73 Q9CXQ6 RFLA_MOUSE uc008zqt.1 uc008zqt.2 uc008zqt.3 Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. Interacts with FLNA and FLNB. Cytoplasm, cytoskeleton Note=Colocalizes with FLNA along actin bundle-like structures. Detected in various tissues, with highest expression in lung, followed by spleen. Expression is first detected in the marginal zone of the vertebral primordia at 12.5 dpc. Expression is subsequently observed during skeletal development in the cartilaginous elements including the vertebral bodies, carpal bones, femora, ribs and caudal vertebrae. At 18.5 dpc, expression is increased in the layers of proliferating and prehypertrophic chondrocytes. Furthermore, expression is also observed in intervertebral disk, including nucleus pulposus and annulus fibrosus, during skeletal development. Up-regulated during chondrocyte differentiation. No visible phenotype; probably due to redundancy with RFLNB. RFLNA and RFLNB double mutant mice exhibit severe skeletal malformations, as characterized by scoliosis, kyphosis, intervertebral disks defects, vertebral fusion in the spine and longitudinal bone growth retardation. Chondrocyte maturation is accelerated in double mutant mice. Belongs to the Refilin family. cytoplasm cytoskeleton filamin binding actin filament bundle skeletal system morphogenesis regulation of chondrocyte development negative regulation of chondrocyte development actin filament bundle organization negative regulation of bone mineralization involved in bone maturation uc008zqt.1 uc008zqt.2 uc008zqt.3 
ENSMUST00000036111.10 Mrps35 ENSMUST00000036111.10 mitochondrial ribosomal protein S35, transcript variant 8 (from RefSeq NR_177445.1) A0A0R4J0L6 A0A0R4J0L6_MOUSE ENSMUST00000036111.1 ENSMUST00000036111.2 ENSMUST00000036111.3 ENSMUST00000036111.4 ENSMUST00000036111.5 ENSMUST00000036111.6 ENSMUST00000036111.7 ENSMUST00000036111.8 ENSMUST00000036111.9 Mrps35 NR_177445 uc057byu.1 uc057byu.2 uc057byu.3 structural constituent of ribosome mitochondrion mitochondrial translation uc057byu.1 uc057byu.2 uc057byu.3 
ENSMUST00000036113.4 Tbc1d16 ENSMUST00000036113.4 TBC1 domain family, member 16, transcript variant 1 (from RefSeq NM_172443.3) A2ABG4 A2ABG4_MOUSE ENSMUST00000036113.1 ENSMUST00000036113.2 ENSMUST00000036113.3 NM_172443 Tbc1d16 uc007mqa.1 uc007mqa.2 uc007mqa.3 uc007mqa.4 regulation of receptor recycling GTPase activator activity early endosome cytosol intracellular protein transport Rab GTPase binding activation of GTPase activity uc007mqa.1 uc007mqa.2 uc007mqa.3 uc007mqa.4 
ENSMUST00000036125.10 Eif4h ENSMUST00000036125.10 eukaryotic translation initiation factor 4H, transcript variant 2 (from RefSeq NM_001312867.1) ENSMUST00000036125.1 ENSMUST00000036125.2 ENSMUST00000036125.3 ENSMUST00000036125.4 ENSMUST00000036125.5 ENSMUST00000036125.6 ENSMUST00000036125.7 ENSMUST00000036125.8 ENSMUST00000036125.9 IF4H_MOUSE NM_001312867 Q9WUK2 Q9WUK3 Wbscr1 uc008zwq.1 uc008zwq.2 uc008zwq.3 uc008zwq.4 This gene encodes eukaryotic translation initiation factor 4H (eIF4H) that plays a critical role in the process of protein synthesis. The encoded protein is an RNA-binding protein that, in concert with other translation initiation factors, helps unwind the 5' cap-proximal region of mRNA to prepare it for ribosomal attachment. Mice lacking the encoded protein displayed growth retardation with a significant reduction of body weight, a smaller brain volume and altered brain morphology. Behaviorally, mice lacking the encoded protein exhibit severe impairments of fear-related associative learning and memory formation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]. Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity). Cytoplasm, perinuclear region. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q9WUK2-1; Sequence=Displayed; Name=Short; IsoId=Q9WUK2-2; Sequence=VSP_005800; Expressed at high levels in heart, liver and testis and at lower levels in brain, spleen, lung, skeletal muscle, kidney and embryonic tissues. Both isoforms are expressed at similar levels. nucleic acid binding RNA binding translation initiation factor activity cytoplasm polysome translation translational initiation sexual reproduction perinuclear region of cytoplasm developmental growth uc008zwq.1 uc008zwq.2 uc008zwq.3 uc008zwq.4 
ENSMUST00000036126.7 Parp2 ENSMUST00000036126.7 poly (ADP-ribose) polymerase family, member 2, transcript variant 1 (from RefSeq NM_009632.4) Adprt2 Adprtl2 Aspartl2 ENSMUST00000036126.1 ENSMUST00000036126.2 ENSMUST00000036126.3 ENSMUST00000036126.4 ENSMUST00000036126.5 ENSMUST00000036126.6 NM_009632 O88554 PARP2_MOUSE Q99N29 uc007tlq.1 uc007tlq.2 uc007tlq.3 Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:12065591). Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:12065591). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (By similarity). Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1 (By similarity). Following interaction with HPF1, catalyzes serine ADP- ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site (By similarity). PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (By similarity). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP2 in order to limit the length of poly-ADP-ribose chains (By similarity). Specifically mediates formation of branched poly-ADP-ribosylation (By similarity). Branched poly-ADP-ribose chains are specifically recognized by some factors, such as APLF (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (By similarity). Reaction=NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H(+).; EC=2.4.2.30; Evidence=; Reaction=L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D- ribosyl)-L-seryl-[protein]; Xref=Rhea:RHEA:58232, Rhea:RHEA- COMP:9863, Rhea:RHEA-COMP:15091, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29999, ChEBI:CHEBI:57540, ChEBI:CHEBI:142556; Evidence=; Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA- COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=; Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence=; ADP-ribosyltransferase activity is regulated via an allosteric activation mechanism. In absence of activation signal, PARP2 is autoinhibited by the PARP alpha-helical domain (also named HD region), which prevents effective NAD(+)-binding. Activity is highly stimulated by signals, which unfold the PARP alpha-helical domain, relieving autoinhibition. Poly-ADP-ribosyltransferase activity is tightly regulated and PARP2 is removed from damaged chromatin following initial poly-ADP-ribosylation of chromatin to avoid prolonged residence (trapping) that has cytotoxic consequences. CHD1L promotes PARP2 removal from chromatin. Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LRIG3 (PubMed:11948190). Homo- and heterodimer with PARP1 (By similarity). Interacts (via the PARP catalytic domain) with HPF1 (By similarity). Interacts with core nucleosomes. Nucleus Chromosome Note=Recruited to DNA damage sites in a PARP1-dependent process: recognizes and binds poly-ADP-ribose chains produced by PARP1 at DNA damage sites via its N-terminus, leading to its recruitment. Widely expressed; the highest levels were in testis followed by ovary (PubMed:11133988). Expression is correlated with proliferation, with higher levels occurring during early fetal development and organogenesis and in the highly proliferative cell compartments of adult (PubMed:11948190). At stage 12.5 dpc, expressed at high level in the developing liver and kidneys (PubMed:11948190). At 18.5 dpc, preferentially expressed in the thymus and in regions of the nervous system (PubMed:11948190). Within the developing trunk, preferential expression persisted in the liver and became restricted to the cortical region of the kidney, spleen, adrenal gland, and to stomach and intestinal epithelia (PubMed:11948190). From 14.5 dpc to 18.5 dpc, as well as in the adult, expressed at the highest level in thymus (PubMed:11948190). Expression is particularly high in the subcapsular zone of the thymus where immature lymphocytes proliferate (PubMed:11948190). By high levels of DNA-damaging agents. The N-terminal region (NTR) recognizes and binds poly-ADP- ribose chains produced by PARP1, leading to its recruitment to DNA damage sites. The N-terminal disordered region does not act as a key DNA- binding domain. The WGR and PARP catalytic domains function together to recruit PARP2 to sites of DNA breaks. The N-terminal disordered region is only required for activation on specific types of DNA damage. The WGR domain bridges two nucleosomes, with the broken DNA aligned in a position suitable for ligation. The bridging induces structural changes in PARP2 that signal the recognition of a DNA break to the catalytic domain of PARP2, promoting HPF1 recruitment and subsequent activation of PARP2, licensing serine ADP-ribosylation of target proteins. The PARP alpha-helical domain (also named HD region) prevents effective NAD(+)-binding in absence of activation signal. Binding to damaged DNA unfolds the PARP alpha-helical domain, relieving autoinhibition. Auto poly-ADP-ribosylated on serine residues, leading to dissociation of the PARP2-HPF1 complex from chromatin (By similarity). Poly-ADP-ribosylated by PARP1 (PubMed:11948190). Acetylation reduces DNA binding and enzymatic activity. Proteolytically cleaved by caspase-8 (CASP8) in response to apoptosis, leading to its inactivation. No visible phenotype in normal conditions, but mutant mice are sensitive to ionizing radiation (PubMed:12727891). Following alkylating agent treatment, cells show increased post- replicative genomic instability, G2/M accumulation and chromosome missegregation accompanying kinetochore defects (PubMed:12727891). Mice lacking both Parp1 and Parp2 are not viable and die at the onset of gastrulation (PubMed:12727891). Female mice lacking both Parp1 and Parp2 in the uterus display infertility; defects are caused by decidualization failure and pregnancy loss (PubMed:34580230). Belongs to the ARTD/PARP family. Sequence=AAC25415.1; Type=Erroneous initiation; Evidence=; DNA binding NAD+ ADP-ribosyltransferase activity protein binding nucleus nucleoplasm nucleolus DNA repair base-excision repair double-strand break repair protein ADP-ribosylation cellular response to DNA damage stimulus transferase activity transferase activity, transferring glycosyl groups peptidyl-serine ADP-ribosylation DNA ADP-ribosylation positive regulation of cell growth involved in cardiac muscle cell development protein poly-ADP-ribosylation extrinsic apoptotic signaling pathway negative regulation of neuron death protein ADP-ribosylase activity uc007tlq.1 uc007tlq.2 uc007tlq.3 
ENSMUST00000036127.9 Hsf4 ENSMUST00000036127.9 heat shock transcription factor 4, transcript variant 4 (from RefSeq NR_045689.1) ENSMUST00000036127.1 ENSMUST00000036127.2 ENSMUST00000036127.3 ENSMUST00000036127.4 ENSMUST00000036127.5 ENSMUST00000036127.6 ENSMUST00000036127.7 ENSMUST00000036127.8 HSF4_MOUSE NR_045689 Q9R0L1 Q9R0L2 uc009ncb.1 uc009ncb.2 uc009ncb.3 Heat-shock transcription factor that specifically binds heat shock promoter elements (HSE) (By similarity). Required for denucleation and organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (By similarity). In this process, may regulate denucleation of lens fiber cells in part by activating DNASE2B transcription (By similarity). May be involved in DNA repair through the transcriptional regulation of RAD51 (By similarity). May up-regulate p53/TP53 protein in eye lens fiber cells, possibly through protein stabilization (By similarity). In the eye lens, controls the expression of alpha-crystallin B chain/CRYAB and consequently may be involved in the regulation of lysosomal acidification (PubMed:31786107). [Isoform HSF4A]: Transcriptional repressor. [Isoform HSF4B]: Transcriptional activator. Homotrimer (PubMed:10488131). Exhibits constitutive DNA binding and forms trimers even in the absence of stress (PubMed:10488131). Interacts with ALKBH4, DUSP26, MAPK1, MAPK2, MAPK8 and MAP kinase p38 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=HSF4B; IsoId=Q9R0L1-1; Sequence=Displayed; Name=HSF4A; IsoId=Q9R0L1-2; Sequence=VSP_002419; Preferentially expressed in brain and lung. Also found in the eye. Slightly detected in liver and skeletal muscle. Isoform B is the major species in various tissues. Phosphorylated mainly on serine residues. Phosphorylation on Ser- 298 promotes sumoylation on Lys-293 (By similarity). Isoform HSF4B is constitutively sumoylated. Sumoylation represses the transcriptional activity and is promoted by phosphorylation on Ser- 298. HSFA is not sumoylated (By similarity). Belongs to the HSF family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding eye development DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated visual perception positive regulation of cell proliferation nuclear speck protein phosphatase binding histone H3-K9 demethylation cellular response to heat identical protein binding camera-type eye development sequence-specific DNA binding positive regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell development protein homooligomerization positive regulation of transcription from RNA polymerase II promoter in response to heat stress uc009ncb.1 uc009ncb.2 uc009ncb.3 
ENSMUST00000036136.9 Colec11 ENSMUST00000036136.9 collectin sub-family member 11, transcript variant 2 (from RefSeq NM_027866.3) A0A0R4J0M6 A0A0R4J0M6_MOUSE Colec11 ENSMUST00000036136.1 ENSMUST00000036136.2 ENSMUST00000036136.3 ENSMUST00000036136.4 ENSMUST00000036136.5 ENSMUST00000036136.6 ENSMUST00000036136.7 ENSMUST00000036136.8 NM_027866 uc007nfr.1 uc007nfr.2 uc007nfr.3 uc007nfr.4 This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in the human gene are a cause of 3MC syndrome-2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. Secreted Belongs to the COLEC10/COLEC11 family. complement activation, lectin pathway DNA binding calcium ion binding mannose binding collagen trimer extracellular space complement activation antimicrobial humoral response fucose binding oligosaccharide binding uc007nfr.1 uc007nfr.2 uc007nfr.3 uc007nfr.4 
ENSMUST00000036153.12 Cops8 ENSMUST00000036153.12 COP9 signalosome subunit 8 (from RefSeq NM_133805.3) CSN8_MOUSE Csn8 ENSMUST00000036153.1 ENSMUST00000036153.10 ENSMUST00000036153.11 ENSMUST00000036153.2 ENSMUST00000036153.3 ENSMUST00000036153.4 ENSMUST00000036153.5 ENSMUST00000036153.6 ENSMUST00000036153.7 ENSMUST00000036153.8 ENSMUST00000036153.9 NM_133805 Q3TRS9 Q80XF4 Q8R4D2 Q8VBV7 uc007bzi.1 uc007bzi.2 uc007bzi.3 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B) (By similarity). Cytoplasm Nucleus Widely expressed. Expressed in embryonic stem (ES) cells and throughout early embryo development from zygote, preimplantation embryos, to post-implantation embryos. Predominantly expressed in the inner cell mass (ICM) of 3.5 dpc blastocyst and widely expressed in 9.5 dpc embryos. Belongs to the CSN8 family. protein deneddylation nucleus nucleoplasm cytoplasm cytosol protein phosphorylation activation of NF-kappaB-inducing kinase activity COP9 signalosome negative regulation of cell proliferation COP9 signalosome assembly perinuclear region of cytoplasm uc007bzi.1 uc007bzi.2 uc007bzi.3 
ENSMUST00000036155.10 Xrra1 ENSMUST00000036155.10 X-ray radiation resistance associated 1 (from RefSeq NM_001164258.1) B2RX67 ENSMUST00000036155.1 ENSMUST00000036155.2 ENSMUST00000036155.3 ENSMUST00000036155.4 ENSMUST00000036155.5 ENSMUST00000036155.6 ENSMUST00000036155.7 ENSMUST00000036155.8 ENSMUST00000036155.9 NM_001164258 Q3U3V8 Q7M740 XRRA1_MOUSE Xrra1 uc009ime.1 uc009ime.2 uc009ime.3 uc009ime.4 May be involved in the response of cells to X-ray radiation. Cytoplasm Nucleus Sequence=DAA00368.1; Type=Erroneous initiation; Evidence=; molecular_function nucleus nucleoplasm cytoplasm response to X-ray nuclear body uc009ime.1 uc009ime.2 uc009ime.3 uc009ime.4 
ENSMUST00000036156.6 Ipo13 ENSMUST00000036156.6 importin 13, transcript variant 3 (from RefSeq NR_185081.1) ENSMUST00000036156.1 ENSMUST00000036156.2 ENSMUST00000036156.3 ENSMUST00000036156.4 ENSMUST00000036156.5 IPO13_MOUSE Kiaa0724 NR_185081 Q6ZQ60 Q8K0C1 uc008ujg.1 uc008ujg.2 uc008ujg.3 Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 (By similarity). Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K0C1-1; Sequence=Displayed; Name=2; IsoId=Q8K0C1-2; Sequence=VSP_010936, VSP_010937; Belongs to the importin beta family. nucleus cytoplasm protein import into nucleus intracellular protein transport Ran GTPase binding protein transport glucocorticoid receptor binding uc008ujg.1 uc008ujg.2 uc008ujg.3 
ENSMUST00000036161.12 Pi4ka ENSMUST00000036161.12 phosphatidylinositol 4-kinase alpha, transcript variant 2 (from RefSeq NM_001001983.3) A0A140T8I9 A0A140T8I9_MOUSE ENSMUST00000036161.1 ENSMUST00000036161.10 ENSMUST00000036161.11 ENSMUST00000036161.2 ENSMUST00000036161.3 ENSMUST00000036161.4 ENSMUST00000036161.5 ENSMUST00000036161.6 ENSMUST00000036161.7 ENSMUST00000036161.8 ENSMUST00000036161.9 NM_001001983 Pi4ka uc007ykr.1 uc007ykr.2 uc007ykr.3 Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. cytoplasm plasma membrane kinase activity phosphorylation transferase activity viral replication complex viral RNA genome replication multi-organism membrane organization viral replication complex formation and maintenance phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling uc007ykr.1 uc007ykr.2 uc007ykr.3 
ENSMUST00000036172.10 Sgpp2 ENSMUST00000036172.10 sphingosine-1-phosphate phosphatase 2 (from RefSeq NM_001004173.2) B2RWL5 ENSMUST00000036172.1 ENSMUST00000036172.2 ENSMUST00000036172.3 ENSMUST00000036172.4 ENSMUST00000036172.5 ENSMUST00000036172.6 ENSMUST00000036172.7 ENSMUST00000036172.8 ENSMUST00000036172.9 NM_001004173 Q810K3 SGPP2_MOUSE Sgpp2 uc007bqe.1 uc007bqe.2 uc007bqe.3 Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (Probable). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (By similarity). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (PubMed:27059959). Reaction=H2O + sphinganine 1-phosphate = phosphate + sphinganine; Xref=Rhea:RHEA:27514, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57817, ChEBI:CHEBI:57939; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27515; Evidence=; Reaction=H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine; Xref=Rhea:RHEA:27518, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27519; Evidence=; Reaction=(4R)-hydroxysphinganine 1-phosphate + H2O = (4R)- hydroxysphinganine + phosphate; Xref=Rhea:RHEA:33067, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:64124, ChEBI:CHEBI:64795; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33068; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Highly expressed in pancreatic islets. Expressed in lung, small interstince, colon, kideny and brain. Developmentally regulated. Expression during kidney development increases around 8 fold from 11.5 dpc and adult. Highest expression is found in the ureteric bud. Mutans are viable into the adulthod. They exhibit smaller pancreatic islets, defective beta-cell proliferation and decreased blood insulin levels after treatment with a high-fat diet (PubMed:27059959). Beta-cells show increased expression of proteins characteristic of the endoplasmic reticulum stress response (PubMed:27059959). Belongs to the type 2 lipid phosphate phosphatase family. endoplasmic reticulum endoplasmic reticulum membrane sphingosine metabolic process membrane integral component of membrane dephosphorylation hydrolase activity sphingosine-1-phosphate phosphatase activity regulation of type B pancreatic cell proliferation uc007bqe.1 uc007bqe.2 uc007bqe.3 
ENSMUST00000036177.9 En2 ENSMUST00000036177.9 engrailed 2, transcript variant 1 (from RefSeq NM_010134.4) ENSMUST00000036177.1 ENSMUST00000036177.2 ENSMUST00000036177.3 ENSMUST00000036177.4 ENSMUST00000036177.5 ENSMUST00000036177.6 ENSMUST00000036177.7 ENSMUST00000036177.8 En2 NM_010134 Q3TZM2 Q3TZM2_MOUSE uc008wtv.1 uc008wtv.2 uc008wtv.3 Nucleus Belongs to the Engrailed homeobox family. fibrillar center DNA binding nucleus nucleolus regulation of transcription, DNA-templated multicellular organism development membrane sequence-specific DNA binding uc008wtv.1 uc008wtv.2 uc008wtv.3 
ENSMUST00000036181.15 Car14 ENSMUST00000036181.15 carbonic anhydrase 14, transcript variant 1 (from RefSeq NM_011797.3) CAH14_MOUSE Ca14 Catm ENSMUST00000036181.1 ENSMUST00000036181.10 ENSMUST00000036181.11 ENSMUST00000036181.12 ENSMUST00000036181.13 ENSMUST00000036181.14 ENSMUST00000036181.2 ENSMUST00000036181.3 ENSMUST00000036181.4 ENSMUST00000036181.5 ENSMUST00000036181.6 ENSMUST00000036181.7 ENSMUST00000036181.8 ENSMUST00000036181.9 NM_011797 Q9WVT6 uc008qls.1 uc008qls.2 uc008qls.3 Reversible hydration of carbon dioxide. Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Inhibited by acetazolamide. Membrane ; Single-pass type I membrane protein Most abundant in the kidney and heart, followed by the skeletal muscle, brain, lung and liver. Belongs to the alpha-carbonic anhydrase family. carbonate dehydratase activity regulation of pH zinc ion binding carbon dioxide transport membrane integral component of membrane lyase activity metal ion binding uc008qls.1 uc008qls.2 uc008qls.3 
ENSMUST00000036187.9 Qsox2 ENSMUST00000036187.9 quiescin Q6 sulfhydryl oxidase 2, transcript variant 2 (from RefSeq NM_153559.3) A2ALE0 A2ALE1 ENSMUST00000036187.1 ENSMUST00000036187.2 ENSMUST00000036187.3 ENSMUST00000036187.4 ENSMUST00000036187.5 ENSMUST00000036187.6 ENSMUST00000036187.7 ENSMUST00000036187.8 NM_153559 Q3TMX7 Q3TZA5 Q8C9I4 Q8K0M2 QSOX2_MOUSE Qscn6l1 uc008iuj.1 uc008iuj.2 uc008iuj.3 uc008iuj.4 This gene encodes a member of the sulfhydryl oxidase protein family. Members of this family catalyze formation of disulfide bonds. A similar protein in humans may sensitize neuroblastoma cells to interferon gamma-induced cell death. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity). Reaction=O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'; Xref=Rhea:RHEA:17357, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:16520, ChEBI:CHEBI:17412; EC=1.8.3.2; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TMX7-1; Sequence=Displayed; Name=2; IsoId=Q3TMX7-2; Sequence=VSP_020501, VSP_020502; Name=3; IsoId=Q3TMX7-3; Sequence=VSP_020500; Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. protein disulfide isomerase activity extracellular space nucleoplasm Golgi apparatus membrane integral component of membrane oxidoreductase activity flavin-linked sulfhydryl oxidase activity thiol oxidase activity integral component of Golgi membrane cell redox homeostasis oxidation-reduction process uc008iuj.1 uc008iuj.2 uc008iuj.3 uc008iuj.4 
ENSMUST00000036188.8 Zc3h12a ENSMUST00000036188.8 zinc finger CCCH type containing 12A (from RefSeq NM_153159.2) ENSMUST00000036188.1 ENSMUST00000036188.2 ENSMUST00000036188.3 ENSMUST00000036188.4 ENSMUST00000036188.5 ENSMUST00000036188.6 ENSMUST00000036188.7 Mcpip Mcpip1 NM_153159 Q3U8J3 Q3UE76 Q5D1E7 Q8JZW9 Q922T4 ZC12A_MOUSE Zc3h12a uc008urx.1 uc008urx.2 uc008urx.3 uc008urx.4 Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:26000482). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:19322177, PubMed:21115689, PubMed:23185455, PubMed:26000482). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (PubMed:23706741, PubMed:26000482, PubMed:19322177, PubMed:21115689, PubMed:23185455). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (PubMed:25282160). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (PubMed:29244194). Self regulates by destabilizing its own mRNA (PubMed:22037600). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19322177, PubMed:23185455, PubMed:23706741, PubMed:26000482, PubMed:26134560). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (By similarity). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (By similarity). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (By similarity). Affects the overall ubiquitination of cellular proteins (PubMed:21115689). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor- associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (PubMed:21115689). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (By similarity). Prevents stress granules (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite- induced oxidative stress, heat shock, and energy deprivation (PubMed:21971051). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (PubMed:25934862). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:18178554, PubMed:19666473, PubMed:22739135). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)- dependent signaling pathway (By similarity). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (PubMed:21616078). Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Mg(2+) is required for RNase activity (PubMed:19322177). ; Oligomer (By similarity). Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta-mediated NF-kappaB activation by promoting IKBKG or TRAF6 deubiquitination. Interacts with IKBKG; this interaction increases in response to DNA damage. Interacts with TANK; this interaction increases in response to DNA damage and serves as a bridge to anchor both TANK and USP10 into a deubiquitinating complex. Interacts with TRAF6; this interaction increases in response to DNA damage and is stimulated by TANK. Interacts with USP10; this interaction increases in response to DNA damage and serves as a bridge to anchor both TANK and USP10 into a deubiquitinating complex. Interacts with ZC3H12D. Interacts with TNRC6A. Interacts with IKBKB/IKKB. Interacts with IKBKB/IKKB (By similarity). Interacts with IKBKB/IKKB (PubMed:22037600). Interacts with BTRC; the interaction occurs when ZC3H12A is phosphorylated in a IKBKB/IKKB-dependent manner (PubMed:22037600). Interacts with IRAK1; this interaction increases the interaction between ZC3H12A and IKBKB/IKKB (PubMed:22037600). Interacts with UPF1; this interaction occurs in a mRNA translationally active- and termination-dependent manner and is essential for ZC3H12A- mediated degradation of target mRNAs (PubMed:26000482). Associates with ribosomes (PubMed:26000482). Interacts with ubiquitin (PubMed:21115689). Q5D1E7; O14920: IKBKB; Xeno; NbExp=4; IntAct=EBI-5326026, EBI-81266; Q5D1E7; P51617: IRAK1; Xeno; NbExp=3; IntAct=EBI-5326026, EBI-358664; Nucleus toplasm ugh endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic granule Cytoplasm, P-body Note=Predominantly localized in the cytoplasm (PubMed:19322177). Colocalizes with GW182 on many granule- like structures, probably corresponding to cytoplasmic GW bodies (GWBs), also called processing bodies (P bodies) (PubMed:21971051). Colocalizes with calnexin on the surface of the rough endoplasmic reticulum (RER) membrane and with translationally active polysomes (PubMed:26000482). Colocalizes with ZC3H12D in cytoplasmic mRNA processing P-body, also known as GW bodies (GWBs) (By similarity). Expressed in CD4(+) helper T-cells (at protein level) (PubMed:29244194). Highly expressed in macrophages (PubMed:18178554). Expressed in lung, lymph nodes, spleen and thymus (PubMed:22037600). Expressed weakly in heart (PubMed:21616078). Expressed weakly in cardiomyocytes (at protein level) (PubMed:16574901). Expressed in spleen, lung, intestine, brown adipose tissue and thymus (PubMed:18682727). Weakly expressed in the heart (PubMed:16574901). Weakly expressed in cardiomyocytes (PubMed:16574901). Up-regulated by the transcription factor KLF4 in a interleukin IL4-dependent manner in macrophage (PubMed:25934862). Up- regulated by lipopolysaccharide (LPS) (at protein level) (PubMed:21616078). Up-regulated by chemokine CCL2 during adipocytes differentiation (PubMed:19666473). Up-regulated in activated T lymphocytes (PubMed:23185455). Up-regulated in response to lipopolysaccharide (LPS) in a MyD88-dependent manner in macrophages (PubMed:18178554, PubMed:18682727, PubMed:19322177). Up-regulated by phorbol 13-acetate 12-myristate (PMA) in primary T lymphocytes (PubMed:23185455). Up-regulated by interleukin IL17 in keratinocytes (PubMed:26320658). The C3H1-type zinc finger domain and C-terminal region are necessary for pre-miRNA binding (By similarity). The C-terminal region and proline-rich domain are necessary for oligomerization (By similarity). Proteolytically cleaved between Arg-111 and Arg-214 by MALT1 in activated T-cells; cleavage at Arg-111 is critical for promoting ZC3H12A degradation in response to T-cell receptor (TCR) stimulation, and hence is necessary for prolonging the stability of a set of mRNAs controlling T-cell activation and Th17 cell differentiation. Phosphorylated by IRAK1; phosphorylation is necessary for subsequent phosphorylation by the I-kappa-B-kinase (IKK) complex. Phosphorylated by I-kappa-B-kinases (IKKs) at Ser-435 and Ser-439 upon lipopolysaccharide (LPS) or IL1B stimulation in macrophages through the MyD88-dependent signaling pathway; these phosphorylations promote rapid ubiquitin proteasome-mediated degradation of ZC3H12A in macrophages and hence allows its target mRNAs, such as IL6, to escape from degradation and accumulate during the inflammatory response (PubMed:22037600). Ubiquitinated; ubiquitination is induced in response to interleukin IL1 receptor stimuli in a IKBKB/IKKB and IRAK1-dependent manner, leading to proteasome-mediated degradation (PubMed:22037600). Note=Increased expression of ZC3H12A is associated with ischemic heart disease (PubMed:16574901). Most mice die within the first 12 weeks (PubMed:21115689). Show severe inflammatory syndromes, including growth retardation, splenomegaly and lymphoadenopathy (PubMed:19322177, PubMed:21115689). show systemic inflammation characterized by T-cell and B-cell activation (PubMed:23706741). Exhibit greatly increased levels of plasma cells and infiltration of plasma cells into the lungs (PubMed:19322177, PubMed:21115689). Show elevated serum immunoglobulin levels and produce anti-nuclear autoantibodies (PubMed:19322177, PubMed:23706741). Mice show increased production of pro-inflammatory cytokine mRNAs and secreted protein levels, such as IL6, TNF and PTGS2 expression upon lipopolysaccharide (LPS) stimulation in bone marrow macrophages (BBMs) or embryonic fibroblasts, particularly in the early phase of the inflammatory response (PubMed:21115689, PubMed:26000482). Show impaired degradation of IL6 mRNA (PubMed:19322177, PubMed:21115689). Show an increased in both JNK and NF-kappa-B signaling pathway activations upon LPS stimulation (PubMed:21115689). Show an increase in global ubiquitinated protein level in splenocytes (PubMed:21115689). Display a drastic increase in both basal and LPS- or TNF-induced ubiquitination of TRAF2, TRAF3 and TRAF6 in splenocytes (PubMed:21115689). Splenocytes show spontaneously formed aggregation of stress granules (SGs) and were resistant to stress-induced apoptosis (PubMed:21971051). Heterozygous knockout mice display IL-17-dependent enhanced resistance to disseminated Candida albicans infection compared to wild-type mice (PubMed:26320658). Double knockout of ZC3H12A and RC3H1 result in embryonic developmental arrest and death; embryonic fibroblasts from these mice show a higher increase in IL6, TNF and PTGS2 expression upon LPS stimulation, both in early and late phases of the responses, compared to single knockout of either ZC3H12A or RC3H1 (PubMed:26000482). T-cell specific conditional knockout mice die within the first 8 to 17 weeks after birth with the development of severe splenomegaly and the development of a severe autoimmune inflammatory disease (PubMed:23706741). Show massive increase in effector/memory T- cells with elevated production of interferon IFNG, interleukins IL17A and IL4 in response to phorbol 13-acetate 12-myristate (PMA) (PubMed:23706741). Proteolytic cleavage is inhibited in T-cells in response to antigen stimulation (PubMed:23706741). Conditional knockout in myeloid cells show impairment in IL4-induced macrophage M2 polarization (PubMed:25934862). Belongs to the ZC3H12 family. nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay P-body angiogenesis negative regulation of protein phosphorylation positive regulation of defense response to virus by host immune system process immune response-activating signal transduction DNA binding chromatin binding RNA binding mRNA binding mRNA 3'-UTR binding nuclease activity endonuclease activity endoribonuclease activity exoribonuclease activity ribonuclease activity thiol-dependent ubiquitin-specific protease activity protein binding nucleus nucleoplasm cytoplasm endoplasmic reticulum rough endoplasmic reticulum cytoskeleton apoptotic process inflammatory response cellular response to DNA damage stimulus multicellular organism development nervous system development regulation of gene expression positive regulation of autophagy positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of gene expression negative regulation of muscle cell apoptotic process positive regulation of lipid storage positive regulation of cell death membrane protein deubiquitination hydrolase activity cell differentiation rough endoplasmic reticulum membrane negative regulation of NF-kappaB transcription factor activity negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production macromolecular complex cellular response to oxidative stress miRNA binding RNA stem-loop binding mRNA 3'-UTR AU-rich region binding cytoplasmic ribonucleoprotein granule cellular response to glucose starvation positive regulation of protein import into nucleus extrinsic component of endoplasmic reticulum membrane ribosome binding negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation by host of viral genome replication negative regulation of nitric oxide biosynthetic process positive regulation of fat cell differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter metal ion binding negative regulation of interleukin-1 beta secretion T cell receptor signaling pathway protein oligomerization negative regulation of cardiac muscle contraction positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic RNA phosphodiester bond hydrolysis, exonucleolytic cellular response to virus negative regulation of cytokine production involved in inflammatory response positive regulation of execution phase of apoptosis negative regulation of interleukin-6 secretion positive regulation of p38MAPK cascade negative regulation of NIK/NF-kappaB signaling negative regulation of interferon-gamma secretion positive regulation of protein deubiquitination negative regulation of production of miRNAs involved in gene silencing by miRNA cellular response to sodium arsenite negative regulation of tumor necrosis factor secretion cellular response to ionomycin cellular response to chemokine negative regulation of T-helper 17 cell differentiation positive regulation of reactive oxygen species metabolic process positive regulation of miRNA catabolic process uc008urx.1 uc008urx.2 uc008urx.3 uc008urx.4 
ENSMUST00000036194.6 Rep15 ENSMUST00000036194.6 RAB15 effector protein (from RefSeq NM_025620.2) ENSMUST00000036194.1 ENSMUST00000036194.2 ENSMUST00000036194.3 ENSMUST00000036194.4 ENSMUST00000036194.5 NM_025620 Q8R1M9 Q9D7R5 Q9D7T1 REP15_MOUSE uc009esr.1 uc009esr.2 uc009esr.3 Regulates transferrin receptor recycling from the endocytic recycling compartment. Interacts with the GTP-bound form of RAB15. Early endosome membrane Note=Colocalizes with RAB11 and RAB15 to the endocytic recycling compartment. Sequence=BAB25994.1; Type=Frameshift; Evidence=; receptor recycling molecular_function endosome endosome membrane membrane early endosome membrane transferrin transport perinuclear region of cytoplasm recycling endosome uc009esr.1 uc009esr.2 uc009esr.3 
ENSMUST00000036206.14 Ccdc92 ENSMUST00000036206.14 coiled-coil domain containing 92, transcript variant 1 (from RefSeq NM_144819.3) CCD92_MOUSE D5Bwg0834e ENSMUST00000036206.1 ENSMUST00000036206.10 ENSMUST00000036206.11 ENSMUST00000036206.12 ENSMUST00000036206.13 ENSMUST00000036206.2 ENSMUST00000036206.3 ENSMUST00000036206.4 ENSMUST00000036206.5 ENSMUST00000036206.6 ENSMUST00000036206.7 ENSMUST00000036206.8 ENSMUST00000036206.9 NM_144819 Q8VDN4 uc008zqr.1 uc008zqr.2 uc008zqr.3 Interferon-stimulated protein that plays a role in innate immunity. Interacts with CEP164. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm Phosphorylated at Ser-192 by TTBK2. molecular_function nucleoplasm cytoplasm centrosome centriole cytoskeleton biological_process intracellular membrane-bounded organelle uc008zqr.1 uc008zqr.2 uc008zqr.3 
ENSMUST00000036210.7 Poglut1 ENSMUST00000036210.7 protein O-glucosyltransferase 1, transcript variant 3 (from RefSeq NR_153380.1) Clp46 ENSMUST00000036210.1 ENSMUST00000036210.2 ENSMUST00000036210.3 ENSMUST00000036210.4 ENSMUST00000036210.5 ENSMUST00000036210.6 Ktelc1 NR_153380 PGLT1_MOUSE Poglut1 Q8BYB9 Q8R0H7 uc007zfc.1 uc007zfc.2 uc007zfc.3 uc007zfc.4 This gene encodes a protein that can catalyze transfer of either UDP-glucose or UDP-xylose to epidermal growth factor (EGF) repeats, such as those found in Notch. Loss of this gene product results in embryonic lethality. Embryos have neural plate defects, heart defects, and truncations of their posterior axis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C- X-S-X-P-C (PubMed:21949356, PubMed:26496195). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21949356, PubMed:26496195). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (By similarity). Notch glucosylation does not affect Notch ligand binding (By similarity). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (PubMed:26496195). Reaction=L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O- (beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:62016, Rhea:RHEA-COMP:16010, Rhea:RHEA-COMP:16011, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:132085; EC=2.4.2.63; Evidence=; Reaction=L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O- (beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:58116, Rhea:RHEA-COMP:14610, Rhea:RHEA-COMP:16010, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885, ChEBI:CHEBI:140576; EC=2.4.1.376; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum lumen Widely expressed in newborn and adult tissues (at protein level). Mutant embryos die at or before 9.5 dpc. At 7.0 to 7.5 dpc, they cannot be morphologically distinguished from wild-type littermates (PubMed:21490058, PubMed:26496195). At 8.0 dpc, mutant embryos exhibit an abnormally expanded neural plate that does not fold properly, absence of heart rudiments and posterior axis truncation (PubMed:21490058). Defects are caused by a deficit of mesoderm caused by impaired gastrulation. Belongs to the glycosyltransferase 90 family. somitogenesis protein binding endoplasmic reticulum endoplasmic reticulum lumen protein glycosylation protein O-linked glycosylation multicellular organism development gastrulation regulation of Notch signaling pathway regulation of gastrulation transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via serine protein xylosyltransferase activity UDP-glucosyltransferase activity UDP-xylosyltransferase activity positive regulation of Notch signaling pathway glucosyltransferase activity axial mesoderm development paraxial mesoderm development muscle tissue development cardiovascular system development uc007zfc.1 uc007zfc.2 uc007zfc.3 uc007zfc.4 
ENSMUST00000036211.8 Gpr12 ENSMUST00000036211.8 G-protein coupled receptor 12, transcript variant 2 (from RefSeq NM_008151.3) ENSMUST00000036211.1 ENSMUST00000036211.2 ENSMUST00000036211.3 ENSMUST00000036211.4 ENSMUST00000036211.5 ENSMUST00000036211.6 ENSMUST00000036211.7 GPR12_MOUSE Gpcr12 NM_008151 P35412 uc009ani.1 uc009ani.2 uc009ani.3 Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production (By similarity). Promotes neurite outgrowth and blocks myelin inhibition in neurons. Cell membrane ; Multi-pass membrane protein Expressed predominantly in the forebrain and a lesser extent in the hindbrain. Lower expression in the liver. Belongs to the G-protein coupled receptor 1 family. Was originally thought to be a receptor for sphingosine 1- phosphate. G-protein coupled receptor activity plasma membrane cellular calcium ion homeostasis signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane phosphatidylcholine binding uc009ani.1 uc009ani.2 uc009ani.3 
ENSMUST00000036215.8 Foxj1 ENSMUST00000036215.8 forkhead box J1 (from RefSeq NM_008240.3) ENSMUST00000036215.1 ENSMUST00000036215.2 ENSMUST00000036215.3 ENSMUST00000036215.4 ENSMUST00000036215.5 ENSMUST00000036215.6 ENSMUST00000036215.7 FOXJ1_MOUSE Foxj1 Hfh4 NM_008240 Q3US42 Q61660 uc007mkv.1 uc007mkv.2 uc007mkv.3 uc007mkv.4 Transcription factor specifically required for the formation of motile cilia (PubMed:9096351, PubMed:9739041, PubMed:10873152, PubMed:14996907, PubMed:22357932, PubMed:27965440). Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157 (PubMed:27965440). Binds the DNA consensus sequences 5'- HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T) (PubMed:9096351). Activates the transcription of a variety of ciliary proteins in the developing brain and lung (PubMed:28666954, PubMed:27914912). Nucleus Predominantly expressed in tissues containing motile cilia. Expressed in the developing fetal lung epithelium and developing brain (at protein level). Mice lack motile respiratory tract cilia and exhibit randomization of the left-right body axis due to loss of motile cilia in the embryonic node (PubMed:9739041, PubMed:10873152). Motile type cilia with a '9 + 2' microtubule ultrastructure are absent in epithelial cells, including those in the airways (PubMed:10873152). Belongs to the FOXJ1 family. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding central tolerance induction negative regulation of germinal center formation positive regulation of central B cell tolerance induction negative regulation of humoral immune response mediated by circulating immunoglobulin DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated humoral immune response determination of left/right symmetry brain development heart development cell projection organization actin cytoskeleton organization regulation of epithelial cell differentiation negative regulation of NF-kappaB transcription factor activity negative regulation of T cell differentiation in thymus establishment of apical/basal cell polarity metanephric part of ureteric bud development negative regulation of T cell proliferation sequence-specific DNA binding motile cilium assembly negative regulation of interleukin-6 biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of B cell activation leukocyte migration cilium assembly lung epithelium development epithelium development left/right pattern formation glomerular parietal epithelial cell development activation of GTPase activity positive regulation of lung ciliated cell differentiation uc007mkv.1 uc007mkv.2 uc007mkv.3 uc007mkv.4 
ENSMUST00000036221.12 Fbxl8 ENSMUST00000036221.12 F-box and leucine-rich repeat protein 8 (from RefSeq NM_015821.2) ENSMUST00000036221.1 ENSMUST00000036221.10 ENSMUST00000036221.11 ENSMUST00000036221.2 ENSMUST00000036221.3 ENSMUST00000036221.4 ENSMUST00000036221.5 ENSMUST00000036221.6 ENSMUST00000036221.7 ENSMUST00000036221.8 ENSMUST00000036221.9 FBXL8_MOUSE Fbl8 NM_015821 Q8CIG9 Q9QZN7 uc009nbz.1 uc009nbz.2 uc009nbz.3 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Directly interacts with SKP1 and CUL1. Widely expressed during embryogenesis and in adult tissues. While the gene symbol and protein names are indicative of the presence of LRR repeats, such repeats are not present in this protein. G2/M transition of mitotic cell cycle nucleus cytosol protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process regulation of cell cycle ubiquitin protein ligase activity uc009nbz.1 uc009nbz.2 uc009nbz.3 
ENSMUST00000036226.6 Fem1c ENSMUST00000036226.6 fem 1 homolog c (from RefSeq NM_173423.4) ENSMUST00000036226.1 ENSMUST00000036226.2 ENSMUST00000036226.3 ENSMUST00000036226.4 ENSMUST00000036226.5 FEM1C_MOUSE Fem1c Kiaa1785 NM_173423 Q3UGV8 Q8C7S4 Q8CEF1 uc008evo.1 uc008evo.2 uc008evo.3 Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg- Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. Protein modification; protein ubiquitination. Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter FEM1C. Widely expressed. Expressed at higher level in testis. The first seven ANK repeats at the N-terminus (1-242) are essnetial for recognition of Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons. Insertion of the beta Geo promoter trap into the Fem1c gene is the cause of ROSA3 mice (PubMed:15082774). Adult ROSA3 mice exhibit widespread expression of the trap gene in epithelial cells found in most organs (PubMed:15082774). Although normal processing of the Fem1c transcript is disrupted in homozygous ROSA3 mice, some tissues show low levels of a partially processed transcript containing exons 2 and 3, which contain the entire coding region of Fem1c (PubMed:15082774). ROSA3 mice show no adverse effects in their sexual development or fertility or in the attenuation of neuronal cell death (PubMed:15082774). Belongs to the fem-1 family. molecular_function nucleoplasm cytoplasm cytosol biological_process protein ubiquitination uc008evo.1 uc008evo.2 uc008evo.3 
ENSMUST00000036227.7 Htr5a ENSMUST00000036227.7 5-hydroxytryptamine (serotonin) receptor 5A, transcript variant 1 (from RefSeq NM_008314.3) 5HT5A_MOUSE 5ht5a ENSMUST00000036227.1 ENSMUST00000036227.2 ENSMUST00000036227.3 ENSMUST00000036227.4 ENSMUST00000036227.5 ENSMUST00000036227.6 NM_008314 P30966 Q3URB0 uc008wtt.1 uc008wtt.2 uc008wtt.3 This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. Cell membrane; Multi-pass membrane protein. Expressed predominantly in the central nervous system; in the cerebral cortex, hippocampus, habenula, olfactory bulb and granular layer of the cerebellum. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity G-protein coupled serotonin receptor activity rough endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting serotonin receptor signaling pathway chemical synaptic transmission brain development membrane integral component of membrane cAMP-mediated signaling hippocampus development dendrite neurotransmitter receptor activity response to estradiol perikaryon serotonin binding integral component of postsynaptic specialization membrane uc008wtt.1 uc008wtt.2 uc008wtt.3 
ENSMUST00000036229.13 Ctdp1 ENSMUST00000036229.13 CTD phosphatase subunit 1 (from RefSeq NM_026295.3) CTDP1_MOUSE ENSMUST00000036229.1 ENSMUST00000036229.10 ENSMUST00000036229.11 ENSMUST00000036229.12 ENSMUST00000036229.2 ENSMUST00000036229.3 ENSMUST00000036229.4 ENSMUST00000036229.5 ENSMUST00000036229.6 ENSMUST00000036229.7 ENSMUST00000036229.8 ENSMUST00000036229.9 Fcp1 NM_026295 Q7TSG2 Q7TSS7 Q9D4S8 uc008ftb.1 uc008ftb.2 uc008ftb.3 Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M- phase-promoting factor (MPF)/CDK1 inactivation (By similarity). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Homodimer. Interacts with GTF2F1 (By similarity). Interacts with WDR77, SNRPB and SNRNP70 (By similarity). Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Midbody Note=Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TSG2-1; Sequence=Displayed; Name=2; IsoId=Q7TSG2-2; Sequence=VSP_009866, VSP_009867; Phosphorylated. In the presence of TFIIF, the phosphorylated form has an increased CTD phosphatase activity. The phosphorylation is required for the physical interaction with GTF2F1 (By similarity). spindle pole TFIIF-class transcription factor binding phosphoprotein phosphatase activity protein binding nucleus nucleoplasm cytoplasm centrosome microtubule organizing center spindle cytoskeleton protein dephosphorylation cell cycle CTD phosphatase activity exit from mitosis hydrolase activity midbody Tat protein binding macromolecular complex intracellular membrane-bounded organelle positive regulation by host of viral transcription spindle midzone cell division negative regulation of cell growth involved in cardiac muscle cell development dephosphorylation of RNA polymerase II C-terminal domain uc008ftb.1 uc008ftb.2 uc008ftb.3 
ENSMUST00000036247.10 C030006K11Rik ENSMUST00000036247.10 RIKEN cDNA C030006K11 gene, transcript variant 2 (from RefSeq NM_176828.4) CH082_MOUSE ENSMUST00000036247.1 ENSMUST00000036247.2 ENSMUST00000036247.3 ENSMUST00000036247.4 ENSMUST00000036247.5 ENSMUST00000036247.6 ENSMUST00000036247.7 ENSMUST00000036247.8 ENSMUST00000036247.9 NM_176828 Q8BK86 Q8VE95 uc007wmf.1 uc007wmf.2 uc007wmf.3 uc007wmf.4 Belongs to the UPF0598 family. molecular_function mitochondrion biological_process uc007wmf.1 uc007wmf.2 uc007wmf.3 uc007wmf.4 
ENSMUST00000036248.13 Pmepa1 ENSMUST00000036248.13 prostate transmembrane protein, androgen induced 1, transcript variant 2 (from RefSeq NM_022995.4) A2APF4 A2APF4_MOUSE ENSMUST00000036248.1 ENSMUST00000036248.10 ENSMUST00000036248.11 ENSMUST00000036248.12 ENSMUST00000036248.2 ENSMUST00000036248.3 ENSMUST00000036248.4 ENSMUST00000036248.5 ENSMUST00000036248.6 ENSMUST00000036248.7 ENSMUST00000036248.8 ENSMUST00000036248.9 NM_022995 Pmepa1 uc008odq.1 uc008odq.2 uc008odq.3 Early endosome membrane ; Single-pass membrane protein Endosome membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein Belongs to the PMEPA1 family. Golgi membrane endosome membrane negative regulation of SMAD protein complex assembly membrane integral component of membrane negative regulation of transforming growth factor beta receptor signaling pathway early endosome membrane intracellular membrane-bounded organelle WW domain binding negative regulation of pathway-restricted SMAD protein phosphorylation R-SMAD binding uc008odq.1 uc008odq.2 uc008odq.3 
ENSMUST00000036267.8 Chst2 ENSMUST00000036267.8 carbohydrate sulfotransferase 2 (from RefSeq NM_018763.2) CHST2_MOUSE E9QNG2 ENSMUST00000036267.1 ENSMUST00000036267.2 ENSMUST00000036267.3 ENSMUST00000036267.4 ENSMUST00000036267.5 ENSMUST00000036267.6 ENSMUST00000036267.7 Gst2 NM_018763 O88276 Q794G9 Q80WV3 uc009raz.1 uc009raz.2 uc009raz.3 uc009raz.4 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. Reaction=3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D- glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl}-L-threonyl-[protein] = 3-O-{6-O-sulfo-N-acetyl-beta- D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:67856, Rhea:RHEA-COMP:17368, Rhea:RHEA- COMP:17369, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:176489, ChEBI:CHEBI:176492; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67857; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D- glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl}-L-seryl-[protein] = 3-O-{6-O-sulfo-N-acetyl-beta-D- glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:67860, Rhea:RHEA-COMP:17365, Rhea:RHEA- COMP:17366, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:176490, ChEBI:CHEBI:176491; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67861; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N- acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}- L-threonyl-[protein] = 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N- acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}- L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:67864, Rhea:RHEA-COMP:14420, Rhea:RHEA-COMP:17370, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:139607, ChEBI:CHEBI:176493; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67865; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N- acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}- L-seryl-[protein] = 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N- acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}- L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:67868, Rhea:RHEA-COMP:14419, Rhea:RHEA-COMP:17367, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:139605, ChEBI:CHEBI:176494; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67869; Evidence=; Protein modification; carbohydrate sulfation. Homodimer; disulfide-linked. Homodimerization is not essential for enzyme activity (By similarity). Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein In brain, it is expressed in pyramidal cells in the CA3 subregion of the hippocampus, cerebellar nucleus and Purkinje cells. Expressed in peripheral lymph nodes. Mice are impaired in the elaboration of sialyl 6- sulfo Lewis X in HEV. Lymphocyte homing to peripheral lymph nodes, mesenteric lymph nodes, and Peyer patches are significantly reduced. Simultaneous knockdown of CHST4 and CHST2 results in lower contact hypersensitivity response when compared to wild-type littermates. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. It is uncertain whether Met-1 or Met-48 is the initiator. Sequence=AAH51963.2; Type=Erroneous initiation; Evidence=; Sequence=BAA32137.1; Type=Erroneous initiation; Evidence=; Sequence=BAA32139.1; Type=Erroneous initiation; Evidence=; Sequence=BAD16775.1; Type=Erroneous initiation; Evidence=; Golgi membrane N-acetylglucosamine 6-O-sulfotransferase activity Golgi apparatus trans-Golgi network carbohydrate metabolic process N-acetylglucosamine metabolic process sulfur compound metabolic process inflammatory response sulfotransferase activity membrane integral component of membrane transferase activity uc009raz.1 uc009raz.2 uc009raz.3 uc009raz.4 
ENSMUST00000036274.8 Spcs2 ENSMUST00000036274.8 signal peptidase complex subunit 2 homolog (S. cerevisiae), transcript variant 1 (from RefSeq NM_025668.4) ENSMUST00000036274.1 ENSMUST00000036274.2 ENSMUST00000036274.3 ENSMUST00000036274.4 ENSMUST00000036274.5 ENSMUST00000036274.6 ENSMUST00000036274.7 NM_025668 Q3THR2 Q80X74 Q921V8 Q9CXK1 Q9CYN2 SPCS2_MOUSE Spc25 uc009imd.1 uc009imd.2 uc009imd.3 Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity). Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3. Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3. Within the complex, interacts with SEC11A or SEC11C and SPCS1. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the SPCS2 family. Sequence=BAB29262.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; endoplasmic reticulum signal peptidase complex endoplasmic reticulum membrane signal peptide processing proteolysis peptidase activity membrane integral component of membrane hydrolase activity organelle membrane intracellular membrane-bounded organelle protein targeting to ER uc009imd.1 uc009imd.2 uc009imd.3 
ENSMUST00000036288.11 R3hdm1 ENSMUST00000036288.11 R3H domain containing 1, transcript variant 1 (from RefSeq NM_181750.2) E9Q9Q2 E9Q9Q2_MOUSE ENSMUST00000036288.1 ENSMUST00000036288.10 ENSMUST00000036288.2 ENSMUST00000036288.3 ENSMUST00000036288.4 ENSMUST00000036288.5 ENSMUST00000036288.6 ENSMUST00000036288.7 ENSMUST00000036288.8 ENSMUST00000036288.9 NM_181750 R3hdm1 uc007clj.1 uc007clj.2 uc007clj.3 nucleic acid binding cellular_component biological_process uc007clj.1 uc007clj.2 uc007clj.3 
ENSMUST00000036300.13 Col27a1 ENSMUST00000036300.13 collagen, type XXVII, alpha 1 (from RefSeq NM_025685.3) CORA1_MOUSE ENSMUST00000036300.1 ENSMUST00000036300.10 ENSMUST00000036300.11 ENSMUST00000036300.12 ENSMUST00000036300.2 ENSMUST00000036300.3 ENSMUST00000036300.4 ENSMUST00000036300.5 ENSMUST00000036300.6 ENSMUST00000036300.7 ENSMUST00000036300.8 ENSMUST00000036300.9 Kiaa1870 NM_025685 Q5QNQ9 Q69Z83 Q80UA8 uc008tfs.1 uc008tfs.2 uc008tfs.3 uc008tfs.4 This gene encodes the alpha-1 subunit of type XXVII collagen, one of the low abundance fibril-forming collagens found in cartilage. The encoded protein forms a homotrimeric triple helical procollagen that undergoes proteolytic processing during fibril formation. Transgenic mice lacking a portion of the collagenous domain in the encoded protein exhibit skeletal abnormalities, chondrodysplasia and die at birth because of a lung defect. [provided by RefSeq, Dec 2015]. ##Evidence-Data-START## Transcript exon combination :: AY167568.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## Plays a role during the calcification of cartilage and the transition of cartilage to bone. Secreted, extracellular space, extracellular matrix te=Found on some small banded collagen fibrils and filamentous meshworks. Highly expressed in cartilage, eye and ear. Expressed in 14.5 dpc in several cartilaginous structures including anlagen of several bones and the developing lungs as well as in the eye, ear and colon. First detectable at 12.5 dpc. At 14.5 dpc localizes to cartilage, developing dermis, cornea, the inner limiting membrane of the retina, and major arteries of the heart. At 18.5 dpc appears restricted mainly to cartilage where expression continued into adulthood. The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity). Belongs to the fibrillar collagen family. growth plate cartilage chondrocyte development extracellular matrix structural constituent extracellular region collagen trimer fibrillar collagen trimer extracellular space extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix metal ion binding uc008tfs.1 uc008tfs.2 uc008tfs.3 uc008tfs.4 
ENSMUST00000036304.5 Pldi ENSMUST00000036304.5 polymorphic derived intron containing (from RefSeq NR_033616.1) ENSMUST00000036304.1 ENSMUST00000036304.2 ENSMUST00000036304.3 ENSMUST00000036304.4 NR_033616 uc007ffg.1 uc007ffg.2 uc007ffg.3 uc007ffg.4 uc007ffg.5 uc007ffg.6 uc007ffg.1 uc007ffg.2 uc007ffg.3 uc007ffg.4 uc007ffg.5 uc007ffg.6 
ENSMUST00000036315.16 Gria1 ENSMUST00000036315.16 glutamate receptor, ionotropic, AMPA1 (alpha 1), transcript variant 1 (from RefSeq NM_001113325.2) ENSMUST00000036315.1 ENSMUST00000036315.10 ENSMUST00000036315.11 ENSMUST00000036315.12 ENSMUST00000036315.13 ENSMUST00000036315.14 ENSMUST00000036315.15 ENSMUST00000036315.2 ENSMUST00000036315.3 ENSMUST00000036315.4 ENSMUST00000036315.5 ENSMUST00000036315.6 ENSMUST00000036315.7 ENSMUST00000036315.8 ENSMUST00000036315.9 GRIA1_MOUSE Glur1 NM_001113325 P23818 uc007izs.1 uc007izs.2 uc007izs.3 uc007izs.4 uc007izs.5 Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Homotetramer or heterotetramer of pore-forming glutamate receptor subunits (By similarity). Tetramers may be formed by the dimerization of dimers (By similarity). Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts with HIP1 and RASGRF2 (PubMed:12839988, PubMed:16407208). Interacts with SYNDIG1 and GRIA2 (PubMed:20152115). Interacts with DLG1 (via C-terminus). Interacts with LRFN1. Interacts with PRKG2. Interacts with CNIH2 and CACNG2. Interacts with CACNG5. Interacts (via C-terminus) with PDLIM4 (via LIM domain); this interaction as well as the interaction of PDLIM4 with alpha- actinin is required for their colocalization in early endosomes. Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (PubMed:23524343). Interacts (via PDZ-binding motif) with SHANK3 (via PDZ domain) (PubMed:16606358). Interacts with CACNG3; associates GRIA1 with the adapter protein complex 4 (AP-4) to target GRIA1 to the somatodendritic compartment of neurons (PubMed:18341993). P23818; O88602: Cacng2; NbExp=2; IntAct=EBI-445486, EBI-770326; P23818; P23819: Gria2; NbExp=4; IntAct=EBI-445486, EBI-77538; Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Postsynaptic cell membrane ulti-pass membrane protein Postsynaptic density membrane ; Multi-pass membrane protein Cell projection, dendrite Cell projection, dendritic spine Early endosome membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Presynapse Synapse Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (PubMed:18341993). Localized to cone photoreceptor pedicles (PubMed:28334377). Expressed in the outer plexiform layer of the retina of the eye (at protein level) (PubMed:28334377). Expressed in the forebrain and hippocampus (at protein level) (PubMed:31651360). The M4 transmembrane segment mediates tetramerization and is required for cell surface expression. Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser- 863 by PKC, PKA and PRKG2 (By similarity). Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation (PubMed:23676497). Palmitoylated. Depalmitoylated by CPT1C and upon glutamate stimulation. ZDHHC3/GODZ specifically palmitoylates Cys-603, which leads to Golgi retention and decreased cell surface expression (PubMed:16129400). In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (PubMed:16129400). The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily. beta-amyloid binding regulation of receptor recycling G-protein alpha-subunit binding ionotropic glutamate receptor activity AMPA glutamate receptor activity ion channel activity protein binding endosome early endosome endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane cell-cell junction ion transport chemical synaptic transmission long-term memory synaptic vesicle protein C-terminus binding glutamate receptor activity adenylate cyclase binding ionotropic glutamate receptor complex response to toxic substance cell surface postsynaptic density ligand-gated ion channel activity membrane integral component of membrane neuronal action potential immunoglobulin binding protein kinase binding protein domain specific binding cell junction PDZ domain binding dendrite small GTPase binding myosin V binding neuromuscular junction receptor internalization G-protein beta-subunit binding beta-2 adrenergic receptor binding early endosome membrane asymmetric synapse AMPA glutamate receptor complex dendrite membrane dendritic spine membrane macromolecular complex ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic somatodendritic compartment signaling receptor activity identical protein binding cell projection neuron projection neuronal cell body dendritic spine dendritic shaft axonal spine neuron spine synapse postsynaptic membrane positive regulation of membrane potential regulation of synaptic plasticity modulation of synaptic transmission positive regulation of synaptic transmission protein kinase A binding recycling endosome recycling endosome membrane excitatory synapse regulation of postsynaptic membrane potential long term synaptic depression synaptic membrane scaffold protein binding postsynapse postsynaptic density membrane glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane integral component of postsynaptic density membrane regulation of postsynaptic cytosolic calcium ion concentration neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc007izs.1 uc007izs.2 uc007izs.3 uc007izs.4 uc007izs.5 
ENSMUST00000036328.9 Zfhx2 ENSMUST00000036328.9 zinc finger homeobox 2 (from RefSeq NM_001039198.1) ENSMUST00000036328.1 ENSMUST00000036328.2 ENSMUST00000036328.3 ENSMUST00000036328.4 ENSMUST00000036328.5 ENSMUST00000036328.6 ENSMUST00000036328.7 ENSMUST00000036328.8 Kiaa1056 NM_001039198 Q2MHN3 Q5DU04 Q80VJ9 ZFHX2_MOUSE Zfhx2 uc007txz.1 uc007txz.2 uc007txz.3 uc007txz.4 zfh-5 Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli. Nucleus Expressed in brain (at protein level) (PubMed:23300874). Expressed at the highest levels in the pyramidal cell layer of the hippocampus, the suprachiasmatic nucleus, laterodorsal thalamic nucleus, lateral geniculate nucleus, substantia nigra pars compacta, and magnocellular part of the red nucleus (at protein level) (PubMed:23300874). Highly expressed in dorsal root ganglia (PubMed:29253101). Expressed at lower levels in kidney, stomach, liver, heart and testis (PubMed:16257534, PubMed:23300874). Detected at 11.5 days post coitum (dpc) in developing brain, and continues to be expressed all the way through to postnatal day 21 (PubMed:23300874). In brain, expressed at 13.5 dpc in thalamus, hypothalamus, midbrain and pontine area (PubMed:16257534). Expression in specific regions of the developing brain is negatively regulated by its antisense mRNA. In particular, down- regulated in pyramidal and granule cells in the hippocampus during early differentiation and the migration stage. Knockout mice exhibit a range of subtle behavioral abnormalities. Locomotor activity is generally increased, but only in familiar environments. There is a slight increase in depression-like behavior, most notably increased immobility in the tail suspension test. Assays of anxiety-like behavior give conflicting results; the open field test indicates a slight reduction in anxiety- like behavior whereas other tests show no significant behavioral changes (PubMed:23300874). Knockout mice are hyposensitive to noxious mechanical stimuli applied to the tail and hypersensitive to noxious heat (PubMed:29253101). Sequence=BAD90426.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated zinc ion binding adult behavior sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated metal ion binding regulation of sensory perception of pain uc007txz.1 uc007txz.2 uc007txz.3 uc007txz.4 
ENSMUST00000036333.14 Prkx ENSMUST00000036333.14 protein kinase, X-linked, transcript variant 1 (from RefSeq NM_016979.2) B1AVU0 ENSMUST00000036333.1 ENSMUST00000036333.10 ENSMUST00000036333.11 ENSMUST00000036333.12 ENSMUST00000036333.13 ENSMUST00000036333.2 ENSMUST00000036333.3 ENSMUST00000036333.4 ENSMUST00000036333.5 ENSMUST00000036333.6 ENSMUST00000036333.7 ENSMUST00000036333.8 ENSMUST00000036333.9 NM_016979 PRKX_MOUSE Pkare Q3UCD1 Q8BHD6 Q922R0 Q9QZ12 uc009tqp.1 uc009tqp.2 uc009tqp.3 uc009tqp.4 uc009tqp.5 Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular- like structure formation. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Binding of cAMP to the PRKAR1A or PRKAR1B regulatory subunits induces dissociation of the holoenzyme heterotetramer. The released monomeric PRKX is then active and able to phosphorylate its substrates (By similarity). Like other cAMP-dependent protein kinases, the inactive holoenzyme is probably composed of 2 PRKX catalytic subunits and a dimer of regulatory subunits. Interacts (cAMP-dependent) specifically with the regulatory subunits PRKAR1A and PRKAR1B. Compared to other cAMP-dependent serine/threonine protein kinases, does not interact with the 2 other PKA regulatory subunits PRKAR2A and PRKAR2B. Interacts with PIN1 (via WW domain). Interacts with cAMP-dependent protein kinase inhibitor/PKI proteins; inhibits PRKX (By similarity). Interacts with GPKOW (By similarity). Interacts with SMAD6 (By similarity). Interacts with PKD1; involved in differentiation and controlled morphogenesis of the kidney (By similarity). Cytoplasm Nucleus Note=cAMP induces nuclear translocation. Widely expressed. Expressed in central nervous system and heart tissues in early development stages and in most organs at later stages (at protein level). Detected in embryos from 9 dpc onward with higher expression in differentiating neuronal tissues at 11.5 dpc. Phosphorylated; autophosphorylates in vitro. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. nucleotide binding angiogenesis endothelial cell proliferation protein kinase activity protein serine/threonine kinase activity cAMP-dependent protein kinase activity ATP binding nucleus cytoplasm cAMP-dependent protein kinase complex protein phosphorylation cell adhesion signal transduction multicellular organism development kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation myeloid cell differentiation cell differentiation regulation of cell adhesion regulation of cell migration cell-substrate adhesion endothelial cell migration protein autophosphorylation epithelial tube morphogenesis kidney morphogenesis regulation of epithelial cell differentiation involved in kidney development uc009tqp.1 uc009tqp.2 uc009tqp.3 uc009tqp.4 uc009tqp.5 
ENSMUST00000036340.12 Fancd2 ENSMUST00000036340.12 Fanconi anemia, complementation group D2, transcript variant q (from RefSeq NM_001033244.3) ENSMUST00000036340.1 ENSMUST00000036340.10 ENSMUST00000036340.11 ENSMUST00000036340.2 ENSMUST00000036340.3 ENSMUST00000036340.4 ENSMUST00000036340.5 ENSMUST00000036340.6 ENSMUST00000036340.7 ENSMUST00000036340.8 ENSMUST00000036340.9 FACD2_MOUSE NM_001033244 Q80V62 Q9CWC7 uc009dgx.1 uc009dgx.2 uc009dgx.3 uc009dgx.4 Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. Interacts directly with FANCE and FANCI. Interacts with USP1 and MEN1. The ubiquitinated form specifically interacts with BRCA1 and BLM. Both the nonubiquitinated and the monoubiquitinated forms interact with BRCA2; this interaction is mediated by phosphorylated FANCG and the complex also includes XCCR3. The ubiquitinated form specifically interacts with MTMR15/FAN1 (via UBZ-type zinc finger), leading to recruit MTMR15/FAN1 to sites of DNA damage. Interacts with DCLRE1B/Apollo. Interacts with POLN. Interacts with UHRF1 and UHRF2; these interactions promote FANCD2 activation. Q80V62; P27661: H2ax; NbExp=2; IntAct=EBI-7268304, EBI-495621; Nucleus Note=Concentrates in nuclear foci during S phase and upon genotoxic stress. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80V62-1; Sequence=Displayed; Name=2; IsoId=Q80V62-2; Sequence=VSP_013889, VSP_013890; Monoubiquitinated on Lys-559 during S phase and upon genotoxic stress by FANCL in complex with E2 ligases UBE2T or UBE2W. Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed. Monoubiquitination requires the joint intervention of the FANC core complex, including FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL and FANCM, and proteins involved in cell cycle checkpoints and DNA repair, including RPA1, ATR, CHEK1 and BRCA1. Ubiquitination is required for binding to chromatin, interaction with BRCA1, BRCA2 and MTMR15/FAN1, DNA repair, and normal cell cycle progression (By similarity). Phosphorylated on several sites including Ser-220 and Ser-1399 in response to genotoxic stress. Mice display delayed pre- and postnatal development, defects in germ-cell development, and increase incidence of microphthalmia and tumors of epithelial cell origin. condensed chromosome protein binding nucleus nucleolus cytosol DNA repair cellular response to DNA damage stimulus cell cycle synapsis multicellular organism development gamete generation response to gamma radiation nuclear body cellular response to oxidative stress regulation of regulatory T cell differentiation brain morphogenesis regulation of inflammatory response regulation of sequence-specific DNA binding transcription factor activity DNA polymerase binding neuronal stem cell population maintenance regulation of CD40 signaling pathway uc009dgx.1 uc009dgx.2 uc009dgx.3 uc009dgx.4 
ENSMUST00000036350.3 Cdnf ENSMUST00000036350.3 cerebral dopamine neurotrophic factor (from RefSeq NM_177647.4) Armetl1 CDNF_MOUSE ENSMUST00000036350.1 ENSMUST00000036350.2 NM_177647 Q8CC36 uc008iej.1 uc008iej.2 Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity). Secreted Expressed at high levels in the heart, skeletal muscle, testis and brain (at protein level). In the brain, detected in the cerebral cortex neurons through layers II to VI. In the hippocampus, detected in the CA1 to CA3 pyramidal regions and in the granule and polymorph layers of dentate gyrus. Weak expression in the striatum. In substantia nigra, detected in solitary cells that did not express tyrosine hydroxylase, a marker for dopaminergic neurons. Relatively high expression in the Purkinje cells of the cerebellum and in regions of the brain stem, including the locus coeruleus. At postnatal stage P1 and P10, expressed in the brain, including the hippocampus, thalamus, striatum and substantia nigra. Highest levels in the hippocampus and thalamus. Belongs to the ARMET family. molecular_function extracellular region extracellular space endoplasmic reticulum signal transduction growth factor activity neuron projection development dopaminergic neuron differentiation uc008iej.1 uc008iej.2 
ENSMUST00000036355.13 Phldb2 ENSMUST00000036355.13 pleckstrin homology like domain, family B, member 2, transcript variant 2 (from RefSeq NM_153412.4) ENSMUST00000036355.1 ENSMUST00000036355.10 ENSMUST00000036355.11 ENSMUST00000036355.12 ENSMUST00000036355.2 ENSMUST00000036355.3 ENSMUST00000036355.4 ENSMUST00000036355.5 ENSMUST00000036355.6 ENSMUST00000036355.7 ENSMUST00000036355.8 ENSMUST00000036355.9 Ll5b NM_153412 PHLB2_MOUSE Q3TNI3 Q80Y16 Q8BKV3 Q8K1N2 uc012agj.1 uc012agj.2 uc012agj.3 uc012agj.4 uc012agj.5 Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane. Interacts with FLNC. Cytoplasm Membrane ; Peripheral membrane protein Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K1N2-1; Sequence=Displayed; Name=2; IsoId=Q8K1N2-2; Sequence=VSP_016746; Expressed at postsynaptic membranes of skeletal neuromuscular junctions (at protein level). In synapses, is expressed at embryonic day 15 and colocalizes with acetyl-choline receptor at prenatal day 4. Expression decreases in adult. The PH domain mediates the binding to phosphoinositides. microtubule cytoskeleton organization cytoplasm cytosol plasma membrane focal adhesion regulation of gastrulation regulation of epithelial to mesenchymal transition membrane cell leading edge intermediate filament cytoskeleton basal cortex establishment of protein localization negative regulation of stress fiber assembly negative regulation of focal adhesion assembly regulation of microtubule cytoskeleton organization negative regulation of wound healing, spreading of epidermal cells positive regulation of basement membrane assembly involved in embryonic body morphogenesis uc012agj.1 uc012agj.2 uc012agj.3 uc012agj.4 uc012agj.5 
ENSMUST00000036362.13 Lat2 ENSMUST00000036362.13 linker for activation of T cells family, member 2, transcript variant 1 (from RefSeq NM_020044.3) ENSMUST00000036362.1 ENSMUST00000036362.10 ENSMUST00000036362.11 ENSMUST00000036362.12 ENSMUST00000036362.2 ENSMUST00000036362.3 ENSMUST00000036362.4 ENSMUST00000036362.5 ENSMUST00000036362.6 ENSMUST00000036362.7 ENSMUST00000036362.8 ENSMUST00000036362.9 Lab NM_020044 NTAL_MOUSE Ntal Q3UYF6 Q9JHL0 Q9JJ29 Wbscr15 Wbscr5 uc008zwn.1 uc008zwn.2 uc008zwn.3 uc008zwn.4 Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL. Cell membrane ingle-pass type III membrane protein Note=Present in lipid rafts. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JHL0-1; Sequence=Displayed; Name=2; IsoId=Q9JHL0-2; Sequence=VSP_016646; Strongly expressed in testis. Expressed in heart, spleen and lung. Present in B-cells and mast cells (at protein level). Hardly expressed in pro-B and pre-B cells. Moderately expressed in immature B-cells, mature B-cells and plasma cells. Highly expressed in transitional B-cells. Phosphorylated on tyrosines following cross-linking of BCR in B- cells, high affinity IgG receptor (FCGR1) in myeloid cells, or high affinity IgE receptor (FCER1) in mast cells; which induces the recruitment of GRB2. Mice exhibit normal T-cell, B-cell and mast cell development and normal humoral response, but have hyperresponsive mast cells. adaptive immune response immune system process immune response-regulating signaling pathway plasma membrane membrane integral component of membrane calcium-mediated signaling intracellular signal transduction B cell activation SH2 domain binding mast cell granule mast cell degranulation membrane raft B cell receptor signaling pathway uc008zwn.1 uc008zwn.2 uc008zwn.3 uc008zwn.4 
ENSMUST00000036370.8 Tagap ENSMUST00000036370.8 T cell activation Rho GTPase activating protein (from RefSeq NM_145968.2) B2RWW0 ENSMUST00000036370.1 ENSMUST00000036370.2 ENSMUST00000036370.3 ENSMUST00000036370.4 ENSMUST00000036370.5 ENSMUST00000036370.6 ENSMUST00000036370.7 NM_145968 Q8K2L9 Q920D6 TAGAP_MOUSE uc008air.1 uc008air.2 uc008air.3 May function as a GTPase-activating protein. May play a role in transmission ratio distortion (TRD) in mouse, in which heterozygous males for t-locus transmit their t-carrying chromosome to 95% or more of their offspring. Highly expressed in testis. Expressed in testis at 7 dpc. Previously thought to be the same gene as Tagap1. These are distinct loci that encode proteins with identical C-termini but each with a unique N-terminus. guanyl-nucleotide exchange factor activity GTPase activator activity signal transduction positive regulation of GTPase activity defense response to virus uc008air.1 uc008air.2 uc008air.3 
ENSMUST00000036372.8 Chsy1 ENSMUST00000036372.8 chondroitin sulfate synthase 1 (from RefSeq NM_001081163.2) CHSS1_MOUSE ENSMUST00000036372.1 ENSMUST00000036372.2 ENSMUST00000036372.3 ENSMUST00000036372.4 ENSMUST00000036372.5 ENSMUST00000036372.6 ENSMUST00000036372.7 Kiaa0990 NM_001081163 Q6ZQ11 uc009hhb.1 uc009hhb.2 Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. Reaction=3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA- (1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl- [protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc- (1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)- beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:20800, Rhea:RHEA-COMP:14058, Rhea:RHEA- COMP:14059, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:138442, ChEBI:CHEBI:138443; EC=2.4.1.175; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20801; Evidence=; Reaction=3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA- (1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)- beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha- D-galactosamine = 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA- (1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal- (1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:55000, Rhea:RHEA-COMP:14060, Rhea:RHEA-COMP:14301, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:138444, ChEBI:CHEBI:138445; EC=2.4.1.175; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55001; Evidence=; Reaction=3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal- (1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D- glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl- [protein] + H(+) + UDP; Xref=Rhea:RHEA:23428, Rhea:RHEA-COMP:12575, Rhea:RHEA-COMP:14058, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132105, ChEBI:CHEBI:138442; EC=2.4.1.226; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23429; Evidence=; Reaction=3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D- GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)- beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta- D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D- GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)- beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:54996, Rhea:RHEA-COMP:14060, Rhea:RHEA-COMP:14061, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:138444, ChEBI:CHEBI:138445; EC=2.4.1.226; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54997; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Cd(2+); Xref=ChEBI:CHEBI:48775; Evidence=; Note=Divalent metal cations. Highest activities are measured with Co(2+), Mn(2+) and Cd(2+). ; Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Secreted Belongs to the chondroitin N- acetylgalactosaminyltransferase family. Sequence=BAC98065.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; chondrocyte development extracellular region Golgi apparatus acetylgalactosaminyltransferase activity proximal/distal pattern formation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups chondroitin sulfate biosynthetic process negative regulation of ossification response to nutrient levels Golgi cisterna membrane positive regulation of smoothened signaling pathway metal ion binding glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity cartilage development sulfation bone morphogenesis uc009hhb.1 uc009hhb.2 
ENSMUST00000036376.13 Tmub2 ENSMUST00000036376.13 transmembrane and ubiquitin-like domain containing 2, transcript variant 2 (from RefSeq NM_028076.4) A2AWT1 ENSMUST00000036376.1 ENSMUST00000036376.10 ENSMUST00000036376.11 ENSMUST00000036376.12 ENSMUST00000036376.2 ENSMUST00000036376.3 ENSMUST00000036376.4 ENSMUST00000036376.5 ENSMUST00000036376.6 ENSMUST00000036376.7 ENSMUST00000036376.8 ENSMUST00000036376.9 NM_028076 Q3V209 Q8K0X0 Q91YQ0 Q9D8C5 TMUB2_MOUSE uc007lrb.1 uc007lrb.2 uc007lrb.3 uc007lrb.4 This gene encodes a predicted multi-pass membrane protein that features a C-terminal ubiquitin-related domain. This gene may be expressed in cone photoreceptors in the retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK132118.1, SRR7974084.765.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3V209-1; Sequence=Displayed; Name=2; IsoId=Q3V209-2; Sequence=VSP_019705; Sequence=AAH16187.1; Type=Erroneous initiation; Evidence=; Sequence=BAB25500.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane ER-associated ubiquitin-dependent protein catabolic process uc007lrb.1 uc007lrb.2 uc007lrb.3 uc007lrb.4 
ENSMUST00000036380.14 Atp6v0b ENSMUST00000036380.14 ATPase, H+ transporting, lysosomal V0 subunit B, transcript variant 4 (from RefSeq NR_185062.1) Atp6f ENSMUST00000036380.1 ENSMUST00000036380.10 ENSMUST00000036380.11 ENSMUST00000036380.12 ENSMUST00000036380.13 ENSMUST00000036380.2 ENSMUST00000036380.3 ENSMUST00000036380.4 ENSMUST00000036380.5 ENSMUST00000036380.6 ENSMUST00000036380.7 ENSMUST00000036380.8 ENSMUST00000036380.9 NR_185062 Q91V37 VATO_MOUSE uc008ujc.1 uc008ujc.2 uc008ujc.3 Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with IFITM3 (PubMed:22467717). Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Multi-pass membrane protein Ubiquitous. Belongs to the V-ATPase proteolipid subunit family. endosome vacuole vacuolar membrane ion transport hydrogen-exporting ATPase activity, phosphorylative mechanism hydrogen ion transmembrane transporter activity membrane integral component of membrane vacuolar proton-transporting V-type ATPase complex proton-transporting two-sector ATPase complex, proton-transporting domain proton-transporting V-type ATPase, V0 domain proton-transporting ATPase activity, rotational mechanism hydrogen ion transmembrane transport uc008ujc.1 uc008ujc.2 uc008ujc.3 
ENSMUST00000036381.10 Chmp7 ENSMUST00000036381.10 charged multivesicular body protein 7 (from RefSeq NM_134078.4) CHMP7_MOUSE ENSMUST00000036381.1 ENSMUST00000036381.2 ENSMUST00000036381.3 ENSMUST00000036381.4 ENSMUST00000036381.5 ENSMUST00000036381.6 ENSMUST00000036381.7 ENSMUST00000036381.8 ENSMUST00000036381.9 NM_134078 Q8CFW4 Q8R1T1 uc007ums.1 uc007ums.2 uc007ums.3 uc007ums.4 ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (By similarity). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (By similarity). Recruited to the reforming NE during anaphase by LEMD2 (By similarity). Plays a role in the endosomal sorting pathway (By similarity). Interacts with CHMP4B, but not with VPS25 (By similarity). Interacts with LEMD2 (via C-terminus) (By similarity). Cytoplasm Nucleus envelope Note=Diffused localization, with some punctate distribution, especially in the perinuclear area. Localizes to the reforming nuclear envelope on chromatin disks during late anaphase. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R1T1-1; Sequence=Displayed; Name=2; IsoId=Q8R1T1-2; Sequence=VSP_015343, VSP_015344; Belongs to the SNF7 family. chromatin ESCRT III complex nucleus nuclear envelope cytoplasm cytosol nucleus organization vacuolar transport mitotic metaphase plate congression exit from mitosis protein transport nuclear envelope reassembly late endosome to vacuole transport protein localization to chromatin uc007ums.1 uc007ums.2 uc007ums.3 uc007ums.4 
ENSMUST00000036383.4 Dnali1 ENSMUST00000036383.4 dynein, axonemal, light intermediate polypeptide 1 (from RefSeq NM_175223.5) Dnali1 ENSMUST00000036383.1 ENSMUST00000036383.2 ENSMUST00000036383.3 IDLC_MOUSE NM_175223 Q0IIN3 Q147V3 Q8BVN8 uc008urp.1 uc008urp.2 uc008urp.3 Involved in sperm flagellum assembly. Interacts with CFAP45 (By similarity). Interacts with DYNC1H1 (PubMed:16496424). Cell projection, cilium Cell projection, cilium, flagellum Dynein axonemal particle Cytoplasm Predominantly expressed in the testis, also detected at lower levels in several tissues expressing cilia (PubMed:16496424). Strongly expressed in elongating spermatid cells (at protein level) (PubMed:16496424). CRISPR-mediated knockout results in loss of sperm motiliy and fibrous sheath abnormalities with asymmetrical distribution of flagellar proteins in a majority of sperm. Nearly half of the knockout mice develop enlarged heads and hydrocephaly. Belongs to the inner dynein arm light chain family. cilium movement motor activity cytoplasm cilium axoneme filopodium dynein complex cell projection dynein heavy chain binding ciliary base 9+2 motile cilium uc008urp.1 uc008urp.2 uc008urp.3 
ENSMUST00000036387.8 S100b ENSMUST00000036387.8 S100 protein, beta polypeptide, neural (from RefSeq NM_009115.3) ENSMUST00000036387.1 ENSMUST00000036387.2 ENSMUST00000036387.3 ENSMUST00000036387.4 ENSMUST00000036387.5 ENSMUST00000036387.6 ENSMUST00000036387.7 NM_009115 Q3UY00 Q3UY00_MOUSE S100b uc007fuc.1 uc007fuc.2 uc007fuc.3 uc007fuc.4 Cytoplasm Nucleus Belongs to the S-100 family. ruffle receptor binding calcium ion binding extracellular space nucleus cytoplasm zinc ion binding positive regulation of cell proliferation regulation of cell shape positive regulation of myelination identical protein binding protein homodimerization activity positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling S100 protein binding metal ion binding calcium-dependent protein binding perinuclear region of cytoplasm astrocyte differentiation RAGE receptor binding positive regulation of synaptic transmission response to glucocorticoid response to methylmercury long-term synaptic potentiation cellular response to hypoxia negative regulation of skeletal muscle cell differentiation uc007fuc.1 uc007fuc.2 uc007fuc.3 uc007fuc.4 
ENSMUST00000036407.6 Fhip2a ENSMUST00000036407.6 FHF complex subunit HOOK interacting protein 2A (from RefSeq NM_145505.4) ENSMUST00000036407.1 ENSMUST00000036407.2 ENSMUST00000036407.3 ENSMUST00000036407.4 ENSMUST00000036407.5 FHI2A_MOUSE Fam160b1 Fhip2a Kiaa1600 NM_145505 Q3T9P9 Q68FM8 Q6P5D5 Q80TB5 Q8C8M2 Q8CDM8 Q8R1V3 uc008iac.1 uc008iac.2 uc008iac.3 uc008iac.4 May be required for proper functioning of the nervous system. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CDM8-1; Sequence=Displayed; Name=2; IsoId=Q8CDM8-2; Sequence=VSP_024592; Belongs to the FHIP family. Sequence=BAC32767.1; Type=Frameshift; Evidence=; Sequence=BC079562; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc008iac.1 uc008iac.2 uc008iac.3 uc008iac.4 
ENSMUST00000036418.10 Ciart ENSMUST00000036418.10 circadian associated repressor of transcription, transcript variant 4 (from RefSeq NM_001411321.1) CIART_MOUSE ENSMUST00000036418.1 ENSMUST00000036418.2 ENSMUST00000036418.3 ENSMUST00000036418.4 ENSMUST00000036418.5 ENSMUST00000036418.6 ENSMUST00000036418.7 ENSMUST00000036418.8 ENSMUST00000036418.9 Gm129 NM_001411321 Q3TQ03 Q3U1B8 uc008qlm.1 uc008qlm.2 uc008qlm.3 Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Abrogates the interaction of BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response. Interacts with BMAL1, PER2, CRY2, BHLHE41, HDAC1 NR3C1. Q3TQ03; Q99PV5: Bhlhe41; NbExp=2; IntAct=EBI-16101489, EBI-6143801; Q3TQ03; Q9WTL8: Bmal1; NbExp=3; IntAct=EBI-16101489, EBI-644534; Q3TQ03; Q9R194: Cry2; NbExp=2; IntAct=EBI-16101489, EBI-1266619; Q3TQ03; O09106: Hdac1; NbExp=2; IntAct=EBI-16101489, EBI-301912; Q3TQ03; O54943: Per2; NbExp=2; IntAct=EBI-16101489, EBI-1266779; Nucleus. Nucleus, PML body. Note=Co-localizes with the CLOCK-BMAL1 heterodimer in the PML body. Expression in the liver oscillates in a circadian manner with highest levels at Zeitgeber time (ZT) 12 hours (at protein level). Expression in the heart, lung, stomach and kidney oscillate in a circadian manner with highest levels at approximately circadian time (CT) 12 hours. Its expression levels peak at circadian time 12 hours (CT12), 8 hours earlier than the peak of PER1/2 and CRY1/2 transcriptional repressors (peak CT20-CT24). Thus, it can repress the CLOCK-BMAL1 activity in a different time window compared to CRY and PER proteins. Mice exhibit a longer circadian period of locomotor activity, alteration in the expression of core clock genes and impairment of the response of the circadian clock to stress. The peaks of DBP, NR1D1 and PER1 gene expression persists longer in the liver between Zeitgeber times (ZT) 12-14 hours. transcription regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding protein binding nucleus PML body circadian regulation of gene expression locomotor rhythm negative regulation of transcription, DNA-templated rhythmic process E-box binding uc008qlm.1 uc008qlm.2 uc008qlm.3 
ENSMUST00000036424.3 Alox12b ENSMUST00000036424.3 arachidonate 12-lipoxygenase, 12R type (from RefSeq NM_009659.2) Alox12b ENSMUST00000036424.1 ENSMUST00000036424.2 NM_009659 Q2KHL0 Q2KHL0_MOUSE uc007jpk.1 uc007jpk.2 uc007jpk.3 This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene can prevent the formation of the epidermal permeability barrier and cause an ichthyosiform phenotype. [provided by RefSeq, Sep 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y14334.1, BC113149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849387 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Note=Binds 1 Fe cation per subunit. ; Lipid metabolism. Belongs to the lipoxygenase family. Lacks conserved residue(s) required for the propagation of feature annotation. arachidonate 12-lipoxygenase activity iron ion binding sphingolipid metabolic process positive regulation of gene expression oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen arachidonic acid metabolic process lipoxygenase pathway positive regulation of MAPK cascade metal ion binding dioxygenase activity oxidation-reduction process positive regulation of mucus secretion uc007jpk.1 uc007jpk.2 uc007jpk.3 
ENSMUST00000036426.13 Prss35 ENSMUST00000036426.13 serine protease 35 (from RefSeq NM_178738.3) ENSMUST00000036426.1 ENSMUST00000036426.10 ENSMUST00000036426.11 ENSMUST00000036426.12 ENSMUST00000036426.2 ENSMUST00000036426.3 ENSMUST00000036426.4 ENSMUST00000036426.5 ENSMUST00000036426.6 ENSMUST00000036426.7 ENSMUST00000036426.8 ENSMUST00000036426.9 NM_178738 PRS35_MOUSE Q8C0D6 Q8C0F9 Q8C0L5 uc012gxu.1 uc012gxu.2 uc012gxu.3 uc012gxu.4 Secreted In ovary, it localizes to the theca cells of pre- antral follicles, the theca and granulosa cells of pre-ovulatory and ovulatory follicles, as well as to the developing corpus luteum. Increases around the time of ovulation and remained elevated in the developing corpus luteum. Expression is progesterone-dependent regulation prior to follicle rupture. Belongs to the peptidase S1 family. Although related to peptidase S1 family, lacks the conserved active Ser residue in position 342 which is replaced by a Thr, suggesting that it has no protease activity. extracellular region mitochondrion uc012gxu.1 uc012gxu.2 uc012gxu.3 uc012gxu.4 
ENSMUST00000036439.6 Cdh6 ENSMUST00000036439.6 cadherin 6 (from RefSeq NM_007666.4) CADH6_MOUSE ENSMUST00000036439.1 ENSMUST00000036439.2 ENSMUST00000036439.3 ENSMUST00000036439.4 ENSMUST00000036439.5 NM_007666 P70393 P97326 Q3KNY8 uc007vif.1 uc007vif.2 uc007vif.3 uc007vif.4 This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein exhibit delay in mesenchyme-to-epithelial conversion and a loss of nephrons. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Oct 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.112966.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cell membrane; Single-pass type I membrane protein. Expressed in fetal, newborn and 7-day-old testis but not in 21-day-old or adult testis. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. cell morphogenesis calcium ion binding plasma membrane cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules Notch signaling pathway cytoskeletal protein binding cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex adherens junction organization protein homodimerization activity cell-cell adhesion mediated by cadherin cadherin binding metal ion binding cell-cell adhesion uc007vif.1 uc007vif.2 uc007vif.3 uc007vif.4 
ENSMUST00000036450.8 Spg11 ENSMUST00000036450.8 SPG11, spatacsin vesicle trafficking associated (from RefSeq NM_145531.3) A2ARM0 ENSMUST00000036450.1 ENSMUST00000036450.2 ENSMUST00000036450.3 ENSMUST00000036450.4 ENSMUST00000036450.5 ENSMUST00000036450.6 ENSMUST00000036450.7 Kiaa1840 NM_145531 Q3UHA3 Q6ZPH3 Q8BHQ1 Q8C7R3 Q8C7U2 Q8CA88 Q8VEA5 SPTCS_MOUSE uc008mac.1 uc008mac.2 uc008mac.3 uc008mac.4 May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. Interacts with AP5Z1, AP5B1, AP5S1 and ZFYVE26. Cytoplasm, cytosol Nucleus Cell projection, axon Cell projection, dendrite Synapse Note=Mainly cytoplasmic. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UHA3-1; Sequence=Displayed; Name=2; IsoId=Q3UHA3-2; Sequence=VSP_025485, VSP_025486; Ubiquitously expressed at low level. Expressed in embryonic and adult cortical projection neurons. Expressed in all brain areas analyzed from embryonic (18 dpc) and adult mice. Sequence=AAH19404.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC30307.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleus nucleolus cytoplasm cytosol plasma membrane lysosome organization chemical synaptic transmission axonogenesis axo-dendritic transport cell junction axon dendrite cytoplasmic vesicle cell projection synapse regulation of synaptic plasticity synaptic vesicle transport axon extension phagosome-lysosome fusion involved in apoptotic cell clearance walking behavior uc008mac.1 uc008mac.2 uc008mac.3 uc008mac.4 
ENSMUST00000036453.14 Map3k10 ENSMUST00000036453.14 mitogen-activated protein kinase kinase kinase 10 (from RefSeq NM_001290528.1) ENSMUST00000036453.1 ENSMUST00000036453.10 ENSMUST00000036453.11 ENSMUST00000036453.12 ENSMUST00000036453.13 ENSMUST00000036453.2 ENSMUST00000036453.3 ENSMUST00000036453.4 ENSMUST00000036453.5 ENSMUST00000036453.6 ENSMUST00000036453.7 ENSMUST00000036453.8 ENSMUST00000036453.9 M3K10_MOUSE NM_001290528 Q66L42 Q80UW4 uc009fwv.1 uc009fwv.2 uc009fwv.3 uc009fwv.4 Activates the JUN N-terminal pathway. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation. Homodimer. Interacts with SH3RF2. Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. nucleotide binding activation of MAPKK activity transcription corepressor activity protein kinase activity protein serine/threonine kinase activity JUN kinase kinase kinase activity MAP kinase kinase kinase activity ATP binding cytoplasm protein phosphorylation smoothened signaling pathway activation of JNKK activity activation of JUN kinase activity cell death kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation positive regulation of apoptotic process bHLH transcription factor binding negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of JUN kinase activity negative regulation of transcription, DNA-templated positive regulation of JNK cascade uc009fwv.1 uc009fwv.2 uc009fwv.3 uc009fwv.4 
ENSMUST00000036456.8 Cep72 ENSMUST00000036456.8 centrosomal protein 72 (from RefSeq NM_028959.3) CEP72_MOUSE E9QQ95 ENSMUST00000036456.1 ENSMUST00000036456.2 ENSMUST00000036456.3 ENSMUST00000036456.4 ENSMUST00000036456.5 ENSMUST00000036456.6 ENSMUST00000036456.7 Kiaa1519 NM_028959 Q3TU12 Q497H8 Q69ZH7 Q8BM53 Q9D0B7 Q9D3R3 uc007req.1 uc007req.2 uc007req.3 uc007req.4 Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (By similarity). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (By similarity). Interacts with KIZ, PCM1 and CDK5RAP2. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule-dependent manner (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D3R3-1; Sequence=Displayed; Name=2; IsoId=Q9D3R3-2; Sequence=VSP_012748, VSP_012749; Belongs to the CEP72 family. Sequence=BAC28870.1; Type=Erroneous initiation; Evidence=; Sequence=BAD32467.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence=; cytoplasm centrosome microtubule organizing center cytoskeleton spindle organization centriole replication gamma-tubulin complex localization centriolar satellite identical protein binding regulation of protein localization to centrosome uc007req.1 uc007req.2 uc007req.3 uc007req.4 
ENSMUST00000036462.12 Atosb ENSMUST00000036462.12 atos homolog B, transcript variant 2 (from RefSeq NM_172691.3) ATOSB_MOUSE Atosb B0QZW6 ENSMUST00000036462.1 ENSMUST00000036462.10 ENSMUST00000036462.11 ENSMUST00000036462.2 ENSMUST00000036462.3 ENSMUST00000036462.4 ENSMUST00000036462.5 ENSMUST00000036462.6 ENSMUST00000036462.7 ENSMUST00000036462.8 ENSMUST00000036462.9 Fam214b Kiaa1539 NM_172691 Q3TTG5 Q3U3I3 Q3UEC3 Q69ZG9 Q6IR39 Q8BR27 uc008spd.1 uc008spd.2 uc008spd.3 Transcription regulator that syncronizes transcriptional and translational programs to promote macrophage invasion of tissues. Nucleus The protein contains a transactivation domain (TAD) which may be required for transcriptional activation of a subset of target genes. Belongs to the ATOS family. Sequence=CAQ12875.1; Type=Erroneous gene model prediction; Evidence=; molecular_function nucleus biological_process uc008spd.1 uc008spd.2 uc008spd.3 
ENSMUST00000036467.5 Asb16 ENSMUST00000036467.5 ankyrin repeat and SOCS box-containing 16 (from RefSeq NM_148953.3) ASB16_MOUSE ENSMUST00000036467.1 ENSMUST00000036467.2 ENSMUST00000036467.3 ENSMUST00000036467.4 NM_148953 Q8BYT0 Q8VHS5 uc007lra.1 uc007lra.2 uc007lra.3 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Belongs to the ankyrin SOCS box (ASB) family. biological_process protein ubiquitination intracellular signal transduction uc007lra.1 uc007lra.2 uc007lra.3 
ENSMUST00000036470.14 Ccdc32 ENSMUST00000036470.14 coiled-coil domain containing 32 (from RefSeq NM_199310.2) Ccdc32 ENSMUST00000036470.1 ENSMUST00000036470.10 ENSMUST00000036470.11 ENSMUST00000036470.12 ENSMUST00000036470.13 ENSMUST00000036470.2 ENSMUST00000036470.3 ENSMUST00000036470.4 ENSMUST00000036470.5 ENSMUST00000036470.6 ENSMUST00000036470.7 ENSMUST00000036470.8 ENSMUST00000036470.9 Gm631 NM_199310 Q3UHY7 Q3UHY7_MOUSE uc008lsx.1 uc008lsx.2 uc008lsx.3 uc008lsx.1 uc008lsx.2 uc008lsx.3 
ENSMUST00000036473.16 Pomt1 ENSMUST00000036473.16 protein-O-mannosyltransferase 1, transcript variant 1 (from RefSeq NM_145145.3) ENSMUST00000036473.1 ENSMUST00000036473.10 ENSMUST00000036473.11 ENSMUST00000036473.12 ENSMUST00000036473.13 ENSMUST00000036473.14 ENSMUST00000036473.15 ENSMUST00000036473.2 ENSMUST00000036473.3 ENSMUST00000036473.4 ENSMUST00000036473.5 ENSMUST00000036473.6 ENSMUST00000036473.7 ENSMUST00000036473.8 ENSMUST00000036473.9 NM_145145 POMT1_MOUSE Q3UYD8 Q64J18 Q8BPJ6 Q8BPU1 Q8R2R1 Q8R474 uc008jeq.1 uc008jeq.2 uc008jeq.3 Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins. Reaction=a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3- O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+); Xref=Rhea:RHEA:17377, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:13546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:137321; EC=2.4.1.109; Evidence=; Reaction=a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+); Xref=Rhea:RHEA:53396, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13547, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:137323; EC=2.4.1.109; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Multi-pass membrane protein Expressed ubiquitously at low level after 7.5 dpc. At 8.5 dpc high levels of expression are detected throughout the neural tube, and in the dorsal aspects of the neural folds of the future midbrain region and the somites. At 9.0 dpc high levels of expression are detected in the ventral domain of the neural tube, developing eye, floor plate, notochord, and gut endothelium. At 10.5 dpc expression high levels of expression are detected in the dermomyotome of the somites, limb-bud mesenchyme, mantle layer of the dorsal neural tube, and developing trigeminal ganglion. Mice suffer of developmental arrest around 7.5 dpc and die between 7.5 dpc and 9.5 dpc. Defects are observed in the formation of Reichert's membrane that are probably due to abnormal glycosylation and maturation of dystroglycan and impaired recruitment of laminin. Belongs to the glycosyltransferase 39 family. Sequence=BAC35577.1; Type=Frameshift; Evidence=; mannosyltransferase activity acrosomal vesicle dolichyl-phosphate-mannose-protein mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation protein O-linked glycosylation membrane integral component of membrane sarcoplasmic reticulum transferase activity transferase activity, transferring glycosyl groups extracellular matrix organization protein O-linked mannosylation positive regulation of protein O-linked glycosylation uc008jeq.1 uc008jeq.2 uc008jeq.3 
ENSMUST00000036489.10 Rsbn1l ENSMUST00000036489.10 round spermatid basic protein 1-like (from RefSeq NM_001080977.1) D3Z0K6 D3Z0K6_MOUSE ENSMUST00000036489.1 ENSMUST00000036489.2 ENSMUST00000036489.3 ENSMUST00000036489.4 ENSMUST00000036489.5 ENSMUST00000036489.6 ENSMUST00000036489.7 ENSMUST00000036489.8 ENSMUST00000036489.9 NM_001080977 Rsbn1l uc008wod.1 uc008wod.2 uc008wod.3 Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Nucleus Belongs to the round spermatid basic protein 1 family. molecular_function nucleus biological_process uc008wod.1 uc008wod.2 uc008wod.3 
ENSMUST00000036493.8 Atp1a1 ENSMUST00000036493.8 ATPase, Na+/K+ transporting, alpha 1 polypeptide (from RefSeq NM_144900.2) AT1A1_MOUSE ENSMUST00000036493.1 ENSMUST00000036493.2 ENSMUST00000036493.3 ENSMUST00000036493.4 ENSMUST00000036493.5 ENSMUST00000036493.6 ENSMUST00000036493.7 NM_144900 Q8VDN2 Q91Z09 uc008qrj.1 uc008qrj.2 uc008qrj.3 uc008qrj.4 This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Reaction=ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate; Xref=Rhea:RHEA:18353, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.13; The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1 (PubMed:17283221). Interacts with regulatory subunit FXYD3 (PubMed:15743908). Interacts with SIK1 (By similarity). Interacts with SLC35G1 and STIM1 (By similarity). Interacts with CLN3; this interaction regulates the sodium/potassium-transporting ATPase complex localization at the plasma membrane (By similarity). Q8VDN2; P11881: Itpr1; NbExp=3; IntAct=EBI-444536, EBI-541478; Q8VDN2; O35157: Slc8a1; NbExp=4; IntAct=EBI-444536, EBI-8351080; Basolateral cell membrane ; Multi-pass membrane protein Cell membrane, sarcolemma ; Multi-pass membrane protein Cell projection, axon Melanosome Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. nucleotide binding regulation of the force of heart contraction regulation of sodium ion transport sodium:potassium-exchanging ATPase activity protein binding ATP binding endosome endoplasmic reticulum Golgi apparatus plasma membrane sodium:potassium-exchanging ATPase complex caveola ion transport potassium ion transport sodium ion transport cellular sodium ion homeostasis regulation of blood pressure potassium-transporting ATPase activity establishment or maintenance of transmembrane electrochemical gradient postsynaptic density intercalated disc membrane integral component of membrane dephosphorylation basolateral plasma membrane apical plasma membrane phosphatase activity protein kinase binding protein domain specific binding cellular potassium ion homeostasis T-tubule ankyrin binding potassium ion binding sodium ion binding negative regulation of glucocorticoid biosynthetic process macromolecular complex sodium ion export from cell sarcolemma response to drug myelin sheath ADP binding phosphatidylinositol 3-kinase binding membrane raft negative regulation of heart contraction positive regulation of heart contraction positive regulation of striated muscle contraction metal ion binding chaperone binding transmembrane transport membrane hyperpolarization cellular response to mechanical stimulus cellular response to steroid hormone stimulus regulation of cardiac muscle cell contraction membrane repolarization steroid hormone binding potassium ion import across plasma membrane response to glycoside uc008qrj.1 uc008qrj.2 uc008qrj.3 uc008qrj.4 
ENSMUST00000036497.16 Prkar2b ENSMUST00000036497.16 protein kinase, cAMP dependent regulatory, type II beta, transcript variant 1 (from RefSeq NM_011158.4) B1B199 ENSMUST00000036497.1 ENSMUST00000036497.10 ENSMUST00000036497.11 ENSMUST00000036497.12 ENSMUST00000036497.13 ENSMUST00000036497.14 ENSMUST00000036497.15 ENSMUST00000036497.2 ENSMUST00000036497.3 ENSMUST00000036497.4 ENSMUST00000036497.5 ENSMUST00000036497.6 ENSMUST00000036497.7 ENSMUST00000036497.8 ENSMUST00000036497.9 KAP3_MOUSE NM_011158 P31324 Q3UTZ1 Q80ZM4 Q8BRZ7 uc007nhy.1 uc007nhy.2 uc007nhy.3 Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with PRKACA and PRKACB. Interacts with the phosphorylated form of PJA2. Forms a complex composed of PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation and regulates GSK3B activity. P31324; Q5S006: Lrrk2; NbExp=3; IntAct=EBI-455340, EBI-2693710; P31324; P05132: Prkaca; NbExp=15; IntAct=EBI-455340, EBI-400564; Cytoplasm Cell membrane Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Phosphorylated by the activated catalytic chain. Belongs to the cAMP-dependent kinase regulatory chain family. nucleotide binding regulation of protein phosphorylation cAMP-dependent protein kinase inhibitor activity protein binding cytoplasm centrosome cytosol plasma membrane cAMP-dependent protein kinase complex fatty acid metabolic process learning cAMP-dependent protein kinase regulator activity membrane protein kinase binding protein domain specific binding cGMP-mediated signaling dendrite cAMP binding ubiquitin protein ligase binding protein kinase A catalytic subunit binding neuronal cell body dendritic spine dendritic shaft membrane raft regulation of protein kinase activity 3',5'-cyclic-GMP phosphodiesterase activity perinuclear region of cytoplasm modulation of synaptic transmission response to antipsychotic drug response to clozapine ciliary base postsynapse glutamatergic synapse negative regulation of cAMP-dependent protein kinase activity uc007nhy.1 uc007nhy.2 uc007nhy.3 
ENSMUST00000036503.14 Zfand4 ENSMUST00000036503.14 zinc finger, AN1-type domain 4, transcript variant 3 (from RefSeq NM_001309446.1) Anubl1 D3Z3C6 ENSMUST00000036503.1 ENSMUST00000036503.10 ENSMUST00000036503.11 ENSMUST00000036503.12 ENSMUST00000036503.13 ENSMUST00000036503.2 ENSMUST00000036503.3 ENSMUST00000036503.4 ENSMUST00000036503.5 ENSMUST00000036503.6 ENSMUST00000036503.7 ENSMUST00000036503.8 ENSMUST00000036503.9 NM_001309446 ZFAN4_MOUSE uc057bxy.1 uc057bxy.2 uc057bxy.3 molecular_function cellular_component biological_process zinc ion binding metal ion binding uc057bxy.1 uc057bxy.2 uc057bxy.3 
ENSMUST00000036509.14 Ubac1 ENSMUST00000036509.14 ubiquitin associated domain containing 1, transcript variant 1 (from RefSeq NM_133835.2) ENSMUST00000036509.1 ENSMUST00000036509.10 ENSMUST00000036509.11 ENSMUST00000036509.12 ENSMUST00000036509.13 ENSMUST00000036509.2 ENSMUST00000036509.3 ENSMUST00000036509.4 ENSMUST00000036509.5 ENSMUST00000036509.6 ENSMUST00000036509.7 ENSMUST00000036509.8 ENSMUST00000036509.9 Kpc2 NM_133835 Q3TZH3 Q8VDI7 UBAC1_MOUSE Ubadc1 uc008itz.1 uc008itz.2 uc008itz.3 uc008itz.4 Non-catalytic component of the KPC complex, a E3 ubiquitin- protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1. The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor. Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome. Protein modification; protein ubiquitination. Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts (via ubiquitin-like domain) with RNF123. Interacts (via ubiquitin-like and UBA domains) with the proteasome via its N-terminal domain. Cytoplasm The UBA domains recognize and bind polyubiquitinated proteins. molecular_function cytoplasm Golgi apparatus cytosol plasma membrane biological_process protein ubiquitination uc008itz.1 uc008itz.2 uc008itz.3 uc008itz.4 
ENSMUST00000036540.12 Fam117b ENSMUST00000036540.12 family with sequence similarity 117, member B (from RefSeq NM_001037725.3) Als2cr13 ENSMUST00000036540.1 ENSMUST00000036540.10 ENSMUST00000036540.11 ENSMUST00000036540.2 ENSMUST00000036540.3 ENSMUST00000036540.4 ENSMUST00000036540.5 ENSMUST00000036540.6 ENSMUST00000036540.7 ENSMUST00000036540.8 ENSMUST00000036540.9 F117B_MOUSE NM_001037725 Q3U3E2 Q68EE3 uc011wlt.1 uc011wlt.2 uc011wlt.3 uc011wlt.4 molecular_function biological_process uc011wlt.1 uc011wlt.2 uc011wlt.3 uc011wlt.4 
ENSMUST00000036541.8 Arl5a ENSMUST00000036541.8 ADP-ribosylation factor-like 5A (from RefSeq NM_182994.2) ARL5A_MOUSE Arl5 ENSMUST00000036541.1 ENSMUST00000036541.2 ENSMUST00000036541.3 ENSMUST00000036541.4 ENSMUST00000036541.5 ENSMUST00000036541.6 ENSMUST00000036541.7 NM_182994 Q80ZU0 uc008jqy.1 uc008jqy.2 uc008jqy.3 Lacks ADP-ribosylation enhancing activity. Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTP binding cytoplasm trans-Golgi network intracellular protein transport vesicle-mediated transport protein localization to Golgi membrane uc008jqy.1 uc008jqy.2 uc008jqy.3 
ENSMUST00000036554.14 Abcc4 ENSMUST00000036554.14 ATP-binding cassette, sub-family C member 4, transcript variant 2 (from RefSeq NM_001163675.1) A0A1C9IC75 Abcc4 B7ZWC5 E9Q236 ENSMUST00000036554.1 ENSMUST00000036554.10 ENSMUST00000036554.11 ENSMUST00000036554.12 ENSMUST00000036554.13 ENSMUST00000036554.2 ENSMUST00000036554.3 ENSMUST00000036554.4 ENSMUST00000036554.5 ENSMUST00000036554.6 ENSMUST00000036554.7 ENSMUST00000036554.8 ENSMUST00000036554.9 MRP4_MOUSE Mrp4 NM_001163675 Q3TZN9 uc007uyv.1 uc007uyv.2 uc007uyv.3 uc007uyv.4 ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.; EC=7.6.2.2; Evidence= Reaction=an S-substituted glutathione(in) + ATP + H2O = ADP + an S- substituted glutathione(out) + H(+) + phosphate; Xref=Rhea:RHEA:19121, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:90779, ChEBI:CHEBI:456216; EC=7.6.2.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19122; Evidence=; Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:82961, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60129; Evidence=; Reaction=ATP + dehydroepiandrosterone 3-sulfate(in) + H2O = ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate; Xref=Rhea:RHEA:61364, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57905, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61365; Evidence=; Reaction=ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate; Xref=Rhea:RHEA:38963, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57973, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38964; Evidence=; Reaction=ATP + H2O + leukotriene B4(in) = ADP + H(+) + leukotriene B4(out) + phosphate; Xref=Rhea:RHEA:66424, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57461, ChEBI:CHEBI:456216; Evidence=; Reaction=ATP + H2O + urate(in) = ADP + H(+) + phosphate + urate(out); Xref=Rhea:RHEA:16461, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17775, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16462; Evidence=; Reaction=3',5'-cyclic GMP(in) + ATP + H2O = 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:66188, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57746, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66189; Evidence=; Reaction=3',5'-cyclic AMP(in) + ATP + H2O = 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:66184, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58165, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66185; Evidence=; Reaction=ATP + H2O + prostaglandin E2(in) = ADP + H(+) + phosphate + prostaglandin E2(out); Xref=Rhea:RHEA:66388, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216, ChEBI:CHEBI:606564; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66389; Evidence=; Reaction=ATP + H2O + prostaglandin E1(in) = ADP + H(+) + phosphate + prostaglandin E1(out); Xref=Rhea:RHEA:66392, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57397, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66393; Evidence=; Reaction=ATP + glutathione(in) + glycodeoxycholate(in) + H2O = ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate; Xref=Rhea:RHEA:66380, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57925, ChEBI:CHEBI:82982, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66381; Evidence=; Reaction=ATP + cholate(in) + glutathione(in) + H2O = ADP + cholate(out) + glutathione(out) + H(+) + phosphate; Xref=Rhea:RHEA:66396, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29747, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57925, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66397; Evidence=; Reaction=ATP + glutathione(in) + glycocholate(in) + H2O = ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate; Xref=Rhea:RHEA:66400, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29746, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57925, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66401; Evidence=; Reaction=ATP + glutathione(in) + H2O + taurocholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurocholate(out); Xref=Rhea:RHEA:66404, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36257, ChEBI:CHEBI:43474, ChEBI:CHEBI:57925, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66405; Evidence=; Reaction=ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O = ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate; Xref=Rhea:RHEA:66408, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36252, ChEBI:CHEBI:43474, ChEBI:CHEBI:57925, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66409; Evidence=; Reaction=ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out); Xref=Rhea:RHEA:66412, ChEBI:CHEBI:9407, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57925, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66413; Evidence=; Reaction=ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O = ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate; Xref=Rhea:RHEA:66416, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57925, ChEBI:CHEBI:132030, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66417; Evidence=; Reaction=ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out); Xref=Rhea:RHEA:66420, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57925, ChEBI:CHEBI:132028, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66421; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); this interaction accelerates MRP4 internalization. Basolateral cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Note=Its localization to the basolateral or apical membranes is tissue-dependent. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=E9Q236-1; Sequence=Displayed; Name=2; IsoId=E9Q236-2; Sequence=VSP_060952; Name=3; Synonyms=ABCC4-N ; IsoId=E9Q236-3; Sequence=VSP_060951, VSP_060952; [Isoform 3]: Ubiquitously expressed across all developmental stages. N-glycosylated; leading to substrate-selective effects on its transport activity. Homozygous null mice are viable and fertile and exhibit any overt phenotype under normal conditions. However deficient mice show impaired anion transport in the blood-brain and blood- cerebrospinal fluid barriers and kidney. Deficient mice show an accumulation of the anticancer agent topotecan in brain and cerebrospinal fluid (CSF) (PubMed:15314169). In addition, penetration of PMEA, an antiviral agent, into the brain is increased in deficient mice (PubMed:17210706). nucleotide binding ATP binding plasma membrane drug transmembrane transport response to organic substance response to organonitrogen compound response to organic cyclic compound prostaglandin transmembrane transporter activity membrane integral component of membrane basolateral plasma membrane ATPase activity platelet dense granule membrane prostaglandin secretion response to drug ATPase activity, coupled to transmembrane movement of substances positive regulation of smooth muscle cell proliferation transmembrane transport cilium assembly uc007uyv.1 uc007uyv.2 uc007uyv.3 uc007uyv.4 
ENSMUST00000036555.8 Myo5c ENSMUST00000036555.8 myosin VC (from RefSeq NM_001081322.1) E9Q1F5 E9Q1F5_MOUSE ENSMUST00000036555.1 ENSMUST00000036555.2 ENSMUST00000036555.3 ENSMUST00000036555.4 ENSMUST00000036555.5 ENSMUST00000036555.6 ENSMUST00000036555.7 Myo5c NM_001081322 uc009qru.1 uc009qru.2 uc009qru.3 uc009qru.4 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. nucleotide binding molecular_function motor activity actin binding ATP binding myosin complex secretory granule establishment of secretory granule localization actin filament binding uc009qru.1 uc009qru.2 uc009qru.3 uc009qru.4 
ENSMUST00000036561.8 Wdr48 ENSMUST00000036561.8 WD repeat domain 48, transcript variant 4 (from RefSeq NR_184638.1) ENSMUST00000036561.1 ENSMUST00000036561.2 ENSMUST00000036561.3 ENSMUST00000036561.4 ENSMUST00000036561.5 ENSMUST00000036561.6 ENSMUST00000036561.7 Kiaa1449 NR_184638 Q80TD4 Q80XI0 Q8BH57 Q8BRM0 Q8CBK0 Q922Z9 Q9CRR1 Q9CSL0 Uaf1 WDR48_MOUSE uc009sbn.1 uc009sbn.2 uc009sbn.3 Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing USP12. Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme. Together with RAD51AP1, promotes DNA repair by stimulating RAD51- mediated homologous recombination. Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). DNA-binding is required both for USP1- mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes.Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress. Interacts with USP46. Interacts with USP1. Interacts with USP12. Component of the USP12-WDR20-WDR48 deubiquitinating complex. Component of the USP12/DMWD/WDR48 deubiquitinating complex. Interacts with PHLPP1. Interacts with RAD51AP1; the interaction is direct and promotes formation of a trimeric complex with RAD51 via RAD51AP1. Interacts with ATAD5; the interaction regulates USP1-mediated PCNA deubiquitination. Interacts with RAD51; the interaction is enhanced under replication stress. Nucleus Cytoplasm Lysosome Late endosome Note=Mainly in cytoplasmic compartments. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BH57-1; Sequence=Displayed; Name=2; IsoId=Q8BH57-2; Sequence=VSP_016778; Name=3; IsoId=Q8BH57-3; Sequence=VSP_016779, VSP_016780; The WD repeats are required for the interaction with deubiquitinating enzymes USP1, USP12 and USP46. Belongs to the WD repeat WDR48 family. Sequence=BAC65793.3; Type=Erroneous initiation; Evidence=; double-strand break repair via homologous recombination nucleus cytoplasm lysosome endosome late endosome cellular response to DNA damage stimulus spermatogenesis single fertilization male gonad development protein deubiquitination multicellular organism growth ubiquitin binding intracellular membrane-bounded organelle skin development embryonic organ development skeletal system morphogenesis homeostasis of number of cells positive regulation of epithelial cell proliferation seminiferous tubule development regulation of protein monoubiquitination positive regulation of protein deubiquitination uc009sbn.1 uc009sbn.2 uc009sbn.3 
ENSMUST00000036564.8 Il22ra2 ENSMUST00000036564.8 interleukin 22 receptor, alpha 2 (from RefSeq NM_178258.5) ENSMUST00000036564.1 ENSMUST00000036564.2 ENSMUST00000036564.3 ENSMUST00000036564.4 ENSMUST00000036564.5 ENSMUST00000036564.6 ENSMUST00000036564.7 I22R2_MOUSE NM_178258 Q3UU14 Q7TNI5 Q80XF5 uc007enh.1 uc007enh.2 uc007enh.3 Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Secreted Highly expressed in lymph nodes and at lower levels in lung, spleen, and thymus. Not expressed in kidney, liver and heart. Belongs to the type II cytokine receptor family. cytokine receptor activity protein binding extracellular region cytosol plasma membrane cytokine-mediated signaling pathway interleukin-22 binding interleukin-22 receptor activity regulation of tyrosine phosphorylation of STAT protein negative regulation of inflammatory response uc007enh.1 uc007enh.2 uc007enh.3 
ENSMUST00000036570.5 Appl1 ENSMUST00000036570.5 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (from RefSeq NM_145221.3) Appl1 DP13A_MOUSE Dip13a ENSMUST00000036570.1 ENSMUST00000036570.2 ENSMUST00000036570.3 ENSMUST00000036570.4 Kiaa1428 NM_145221 Q3UJP7 Q69ZJ9 Q8BWZ8 Q8K3H0 Q8VCJ8 Q9CUW4 uc007sth.1 uc007sth.2 uc007sth.3 Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (By similarity) (PubMed:25328665, PubMed:25568335, PubMed:27219021). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (PubMed:25328665). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (PubMed:25568335). Regulates TLR4 signaling in activated macrophages (PubMed:27219021). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6- dependent manner. Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (By similarity). Required for fibroblast migration through HGF cell signaling (PubMed:26445298). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (By similarity). Homodimer. Binds RAB5A/Rab5 through an N-terminal domain. This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex (By similarity). Interacts with OCRL and INPP5B (PubMed:20133602) (By similarity). Interacts with NTRK2 (PubMed:21849472). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation; interaction is decreased by adiponectin in a time-dependent manner (PubMed:25328665). Forms a complex with APPL2 and RUVBL2. Forms a complex comprising APPL2, RUVBL2, CTNNB1, HDAC1 and HDAC2; interaction reduces interaction between CTNNB1, HDAC1, HDAC2 and RUVBL2 leading to the decrease of deacetylase activity of this complex; affects the recruitment of repressive complexes to the Wnt target genes. Interacts with ANXA2. Interacts with TGFBR1; interaction is TGF beta dependent; mediates trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner. Interacts with PRKCZ (By similarity). Interacts with PIK3R1 and APPL2 (PubMed:25328665). Interacts with ADIPOR1; ADIPOQ enhances this interaction; inhibites adiponectin-stimulated binding of APPL2 to ADIPOR1 (PubMed:19661063). Early endosome membrane ; Peripheral membrane protein Nucleus Cytoplasm Endosome Cell projection, ruffle Cytoplasmic vesicle, phagosome Note=Early endosomal membrane- bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. Expressed in insulin-target tissues including skeletal muscle, liver, fat, and brain. Overexpression of an N-terminal domain (residues 1-319) or a C- terminal region (residues 273-707) has a proapoptotic effect. The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B. Phosphorylation at Ser-410 by PKA severely impairs binding to OCRL. Reduced survival rate after injection of LPS (PubMed:25328665). Appl1 and Appl2 double knockout mice are viable and grossly normal with regard to reproductive potential and postnatal growth (PubMed:26445298). Sequence=AAH19708.1; Type=Erroneous initiation; Evidence=; Sequence=AAH19708.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; ruffle phosphatidylserine binding protein binding nucleus cytoplasm endosome early endosome cytosol plasma membrane protein import into nucleus cell cycle transforming growth factor beta receptor signaling pathway cell proliferation insulin receptor signaling pathway endosome membrane regulation of fibroblast migration vesicle membrane membrane signaling cytoplasmic vesicle early endosome membrane early phagosome adiponectin-activated signaling pathway regulation of toll-like receptor 4 signaling pathway phosphatidylinositol binding cellular response to hepatocyte growth factor stimulus identical protein binding protein homodimerization activity cell projection protein kinase B binding macropinosome macromolecular complex binding regulation of innate immune response phagocytic vesicle regulation of glucose import positive regulation of glucose import positive regulation of melanin biosynthetic process beta-tubulin binding intracellular vesicle positive regulation of cytokine production involved in inflammatory response regulation of protein localization to plasma membrane positive regulation of macropinocytosis negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis uc007sth.1 uc007sth.2 uc007sth.3 
ENSMUST00000036572.4 Tmem51 ENSMUST00000036572.4 transmembrane protein 51, transcript variant 1 (from RefSeq NM_145402.4) ENSMUST00000036572.1 ENSMUST00000036572.2 ENSMUST00000036572.3 NM_145402 Q3TPZ3 Q99LG1 TMM51_MOUSE uc008vpr.1 uc008vpr.2 uc008vpr.3 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc008vpr.1 uc008vpr.2 uc008vpr.3 
ENSMUST00000036575.16 Obox2 ENSMUST00000036575.16 oocyte specific homeobox 2 (from RefSeq NM_145708.2) E9PXV9 ENSMUST00000036575.1 ENSMUST00000036575.10 ENSMUST00000036575.11 ENSMUST00000036575.12 ENSMUST00000036575.13 ENSMUST00000036575.14 ENSMUST00000036575.15 ENSMUST00000036575.2 ENSMUST00000036575.3 ENSMUST00000036575.4 ENSMUST00000036575.5 ENSMUST00000036575.6 ENSMUST00000036575.7 ENSMUST00000036575.8 ENSMUST00000036575.9 NM_145708 OBOX2_MOUSE Obox2 Q8VHG7 uc009fgg.1 uc009fgg.2 uc009fgg.3 uc009fgg.4 uc009fgg.5 In contrast to other Obox family proteins, displays a truncated homeobox domain and does not bind DNA. Specifically expressed in oocytes and early embryos. Expressed maternally with high expression in oocytes and early embryos before expression declines after zygotic genome activation (ZGA). Female mice lacking maternally transcribed Obox1, Obox2, Obox5, Obox7 as well as zygotically expressed Obox3 and Obox4 are infertile: embryos arrest at two-four cell stage due to impaired zygotic genome activation (ZGA). Belongs to the paired homeobox family. Obox subfamily. Sequence=AAL68801.1; Type=Erroneous gene model prediction; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding uc009fgg.1 uc009fgg.2 uc009fgg.3 uc009fgg.4 uc009fgg.5 
ENSMUST00000036576.10 Ccdc138 ENSMUST00000036576.10 coiled-coil domain containing 138 (from RefSeq NM_001162956.1) CC138_MOUSE ENSMUST00000036576.1 ENSMUST00000036576.2 ENSMUST00000036576.3 ENSMUST00000036576.4 ENSMUST00000036576.5 ENSMUST00000036576.6 ENSMUST00000036576.7 ENSMUST00000036576.8 ENSMUST00000036576.9 NM_001162956 Q0VF22 Q8CG93 uc007fdf.1 uc007fdf.2 uc007fdf.3 uc007fdf.4 molecular_function cellular_component biological_process uc007fdf.1 uc007fdf.2 uc007fdf.3 uc007fdf.4 
ENSMUST00000036578.7 Bahd1 ENSMUST00000036578.7 bromo adjacent homology domain containing 1 (from RefSeq NM_001045523.2) Bahd1 ENSMUST00000036578.1 ENSMUST00000036578.2 ENSMUST00000036578.3 ENSMUST00000036578.4 ENSMUST00000036578.5 ENSMUST00000036578.6 NM_001045523 Z4YJL0 Z4YJL0_MOUSE uc008lsw.1 uc008lsw.2 uc008lsw.3 chromatin binding nucleoplasm chromatin silencing complex heterochromatin assembly negative regulation of transcription, DNA-templated uc008lsw.1 uc008lsw.2 uc008lsw.3 
ENSMUST00000036606.14 Stard8 ENSMUST00000036606.14 StAR related lipid transfer domain containing 8 (from RefSeq NM_199018.2) B1AZJ2 ENSMUST00000036606.1 ENSMUST00000036606.10 ENSMUST00000036606.11 ENSMUST00000036606.12 ENSMUST00000036606.13 ENSMUST00000036606.2 ENSMUST00000036606.3 ENSMUST00000036606.4 ENSMUST00000036606.5 ENSMUST00000036606.6 ENSMUST00000036606.7 ENSMUST00000036606.8 ENSMUST00000036606.9 Kiaa0189 NM_199018 Q3UZC7 Q6A0A8 Q6P5E0 Q8K031 Q8R3X8 STAR8_MOUSE uc009tvg.1 uc009tvg.2 uc009tvg.3 Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1 (By similarity). Binds both the SH2 and PTB domains of TNS1. Cell junction, focal adhesion molecular_function GTPase activator activity focal adhesion signal transduction lipid binding cell junction positive regulation of GTPase activity uc009tvg.1 uc009tvg.2 uc009tvg.3 
ENSMUST00000036615.7 Hacd3 ENSMUST00000036615.7 3-hydroxyacyl-CoA dehydratase 3 (from RefSeq NM_021345.2) ENSMUST00000036615.1 ENSMUST00000036615.2 ENSMUST00000036615.3 ENSMUST00000036615.4 ENSMUST00000036615.5 ENSMUST00000036615.6 HACD3_MOUSE Hacd3 NM_021345 O09003 Ptplad1 Q6PGH3 Q8BGM8 Q8K2C9 uc009qcp.1 uc009qcp.2 uc009qcp.3 uc009qcp.4 Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Involved in Rac1- signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity). Reaction=a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O; Xref=Rhea:RHEA:45812, ChEBI:CHEBI:15377, ChEBI:CHEBI:83728, ChEBI:CHEBI:85440; EC=4.2.1.134; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45813; Evidence=; Reaction=(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O; Xref=Rhea:RHEA:39159, ChEBI:CHEBI:15377, ChEBI:CHEBI:61526, ChEBI:CHEBI:74278; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39160; Evidence=; Lipid metabolism; fatty acid biosynthesis. May interact with enzymes of the ELO family (including ELOVL1); with those enzymes that mediate condensation, the first of the four steps of the reaction cycle responsible for fatty acids elongation, may be part of a larger fatty acids elongase complex. Interacts with RAC1. Associates with internalized insulin receptor/INSR complexes on Golgi/endosomal membranes; HACD3/PTPLAD1 together with ATIC and PRKAA2/AMPK2 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis (By similarity). Q8K2C9; Q13200: PSMD2; Xeno; NbExp=2; IntAct=EBI-8329978, EBI-357648; Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the very long-chain fatty acids dehydratase HACD family. Shares some similarity with tyrosine phosphatase proteins but it has probably no phosphatase activity. protein binding mitochondrion endoplasmic reticulum endoplasmic reticulum membrane cytosol lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process I-kappaB kinase/NF-kappaB signaling JNK cascade Rho protein signal transduction membrane integral component of membrane lyase activity 3-hydroxyacyl-CoA dehydratase activity enzyme binding sphingolipid biosynthetic process integral component of endoplasmic reticulum membrane fatty acid elongation nuclear membrane very long-chain fatty acid biosynthetic process positive regulation of viral genome replication positive regulation by virus of viral protein levels in host cell 3-hydroxy-behenoyl-CoA dehydratase activity 3-hydroxy-lignoceroyl-CoA dehydratase activity uc009qcp.1 uc009qcp.2 uc009qcp.3 uc009qcp.4 
ENSMUST00000036618.14 Stab1 ENSMUST00000036618.14 stabilin 1 (from RefSeq NM_138672.2) ENSMUST00000036618.1 ENSMUST00000036618.10 ENSMUST00000036618.11 ENSMUST00000036618.12 ENSMUST00000036618.13 ENSMUST00000036618.2 ENSMUST00000036618.3 ENSMUST00000036618.4 ENSMUST00000036618.5 ENSMUST00000036618.6 ENSMUST00000036618.7 ENSMUST00000036618.8 ENSMUST00000036618.9 G3X973 G3X973_MOUSE NM_138672 Stab1 uc007swv.1 uc007swv.2 uc007swv.3 Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. low-density lipoprotein receptor activity scavenger receptor activity calcium ion binding hyaluronic acid binding integral component of plasma membrane endocytosis cell adhesion cell-cell signaling membrane integral component of membrane negative regulation of angiogenesis low-density lipoprotein particle binding defense response to bacterium uc007swv.1 uc007swv.2 uc007swv.3 
ENSMUST00000036619.14 AW554918 ENSMUST00000036619.14 expressed sequence AW554918, transcript variant 2 (from RefSeq NM_001405457.1) AW554918 E9QPX6 E9QPX6_MOUSE ENSMUST00000036619.1 ENSMUST00000036619.10 ENSMUST00000036619.11 ENSMUST00000036619.12 ENSMUST00000036619.13 ENSMUST00000036619.2 ENSMUST00000036619.3 ENSMUST00000036619.4 ENSMUST00000036619.5 ENSMUST00000036619.6 ENSMUST00000036619.7 ENSMUST00000036619.8 ENSMUST00000036619.9 NM_001405457 uc289oke.1 uc289oke.2 uc289oke.1 uc289oke.2 
ENSMUST00000036631.14 Dusp26 ENSMUST00000036631.14 dual specificity phosphatase 26, transcript variant 1 (from RefSeq NM_025869.4) DUS26_MOUSE ENSMUST00000036631.1 ENSMUST00000036631.10 ENSMUST00000036631.11 ENSMUST00000036631.12 ENSMUST00000036631.13 ENSMUST00000036631.2 ENSMUST00000036631.3 ENSMUST00000036631.4 ENSMUST00000036631.5 ENSMUST00000036631.6 ENSMUST00000036631.7 ENSMUST00000036631.8 ENSMUST00000036631.9 NM_025869 Q8VCZ5 Q9D700 Skrp3 uc009ljb.1 uc009ljb.2 uc009ljb.3 Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Interacts with HSF4. Cytoplasm Nucleus Golgi apparatus Brain and skeletal muscle. In the brain it is expressed ubiquitously except in the hippocampus. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding p53 binding phosphoserine phosphatase activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm mitochondrion Golgi apparatus protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation negative regulation of protein kinase activity by regulation of protein phosphorylation positive regulation of cell adhesion negative regulation of ERK1 and ERK2 cascade positive regulation of peptidyl-serine dephosphorylation uc009ljb.1 uc009ljb.2 uc009ljb.3 
ENSMUST00000036643.6 Lrrc52 ENSMUST00000036643.6 leucine rich repeat containing 52 (from RefSeq NM_001013382.3) ENSMUST00000036643.1 ENSMUST00000036643.2 ENSMUST00000036643.3 ENSMUST00000036643.4 ENSMUST00000036643.5 LRC52_MOUSE NM_001013382 Q5M8M9 uc007dkz.1 uc007dkz.2 uc007dkz.3 Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity). KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties, shifting KCNU1 gating to more negative potentials at a given pH. Interacts with KCNMA1 (By similarity). May interact with KCNU1; this interaction may be required for LRRC52 stability and may change the channel gating properties. Cell membrane ; Single-pass membrane protein Note=Expression at the cell surface may require the presence of KCNU1. Testis-specific (at protein level). At the mRNA level, also detected in kidney, ventricle, spinal cord and skeletal muscle, although at lower levels compared to testis. Expression in testis at the protein level requires the presence of KCNU1. Very low expression levels in testis before postnatal day 25 (P25). Levels strongly increase between P25 and P30, and then remain high from P30 through P150. The transmembrane domain is necessary for interaction with KCNMA1. N-glycosylated. voltage-gated potassium channel activity potassium channel activity plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane reproductive process ion channel binding potassium ion transmembrane transport potassium channel activator activity positive regulation of voltage-gated potassium channel activity uc007dkz.1 uc007dkz.2 uc007dkz.3 
ENSMUST00000036647.13 Ctdspl2 ENSMUST00000036647.13 CTD small phosphatase like 2, transcript variant 1 (from RefSeq NM_212450.4) A2ARL6 CTSL2_MOUSE D2Ertd485e ENSMUST00000036647.1 ENSMUST00000036647.10 ENSMUST00000036647.11 ENSMUST00000036647.12 ENSMUST00000036647.2 ENSMUST00000036647.3 ENSMUST00000036647.4 ENSMUST00000036647.5 ENSMUST00000036647.6 ENSMUST00000036647.7 ENSMUST00000036647.8 ENSMUST00000036647.9 NM_212450 Q3TF86 Q3TQW7 Q3TV36 Q7TPZ9 Q8BG15 Q8BPR3 Q8C9S0 Q8CEG6 uc008lzy.1 uc008lzy.2 uc008lzy.3 uc008lzy.4 Probable phosphatase. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8BG15-1; Sequence=Displayed; Name=2; IsoId=Q8BG15-2; Sequence=VSP_033220; Name=3; IsoId=Q8BG15-3; Sequence=VSP_033223; Name=4; IsoId=Q8BG15-4; Sequence=VSP_033219, VSP_033224; Name=5; IsoId=Q8BG15-5; Sequence=VSP_033222; Name=6; IsoId=Q8BG15-6; Sequence=VSP_033221; Belongs to the CTDSPL2 family. Sequence=BAC25842.1; Type=Erroneous initiation; Evidence=; phosphoprotein phosphatase activity nucleus nucleoplasm protein dephosphorylation hydrolase activity phosphatase activity negative regulation of BMP signaling pathway positive regulation of protein export from nucleus uc008lzy.1 uc008lzy.2 uc008lzy.3 uc008lzy.4 
ENSMUST00000036649.8 Coil ENSMUST00000036649.8 coilin (from RefSeq NM_016706.2) Coil E9Q284 E9Q284_MOUSE ENSMUST00000036649.1 ENSMUST00000036649.2 ENSMUST00000036649.3 ENSMUST00000036649.4 ENSMUST00000036649.5 ENSMUST00000036649.6 ENSMUST00000036649.7 NM_016706 uc288bhq.1 uc288bhq.2 fibrillar center nucleus nucleoplasm nucleolus protein C-terminus binding Cajal body nuclear body identical protein binding uc288bhq.1 uc288bhq.2 
ENSMUST00000036653.5 Htr2a ENSMUST00000036653.5 5-hydroxytryptamine (serotonin) receptor 2A (from RefSeq NM_172812.3) ENSMUST00000036653.1 ENSMUST00000036653.2 ENSMUST00000036653.3 ENSMUST00000036653.4 Htr2a NM_172812 Q543D4 Q543D4_MOUSE uc007uqc.1 uc007uqc.2 uc007uqc.3 G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Cell membrane ; Multi-pass membrane protein Cell projection, dendrite ll projection, axon Cytoplasmic vesicle mbrane, caveola Presynapse Membrane ; Multi-pass membrane protein Synapse Vesicle Belongs to the G-protein coupled receptor 1 family. temperature homeostasis G-protein alpha-subunit binding G-protein coupled receptor activity G-protein coupled serotonin receptor activity cytoplasm cytosol plasma membrane integral component of plasma membrane cellular calcium ion homeostasis signal transduction G-protein coupled receptor signaling pathway activation of phospholipase C activity positive regulation of cytosolic calcium ion concentration phospholipase C-activating serotonin receptor signaling pathway serotonin receptor signaling pathway aging memory drug binding cell death positive regulation of cell proliferation positive regulation of phosphatidylinositol biosynthetic process regulation of dopamine secretion phosphatidylinositol 3-kinase signaling artery smooth muscle contraction urinary bladder smooth muscle contraction membrane integral component of membrane sensory perception of pain dendrite sleep response to drug neuronal cell body dendritic shaft negative regulation of potassium ion transport positive regulation of MAP kinase activity macromolecular complex binding positive regulation of vasoconstriction behavioral response to cocaine detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain release of sequestered calcium ion into cytosol serotonin binding negative regulation of synaptic transmission, glutamatergic positive regulation of ERK1 and ERK2 cascade cell body fiber 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane regulation of synaptic vesicle exocytosis uc007uqc.1 uc007uqc.2 uc007uqc.3 
ENSMUST00000036665.10 Cog6 ENSMUST00000036665.10 component of oligomeric golgi complex 6 (from RefSeq NM_026225.3) A0A0R4J0L5 A0A0R4J0L5_MOUSE Cog6 ENSMUST00000036665.1 ENSMUST00000036665.2 ENSMUST00000036665.3 ENSMUST00000036665.4 ENSMUST00000036665.5 ENSMUST00000036665.6 ENSMUST00000036665.7 ENSMUST00000036665.8 ENSMUST00000036665.9 NM_026225 uc008pen.1 uc008pen.2 uc008pen.3 uc008pen.4 Required for normal Golgi function. Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Golgi apparatus membrane ; Peripheral membrane protein mbrane ; Peripheral membrane protein Belongs to the COG6 family. Golgi membrane Golgi apparatus intra-Golgi vesicle-mediated transport protein transport membrane Golgi transport complex glycosylation uc008pen.1 uc008pen.2 uc008pen.3 uc008pen.4 
ENSMUST00000036680.8 Thap3 ENSMUST00000036680.8 THAP domain containing, apoptosis associated protein 3, transcript variant 1 (from RefSeq NM_175152.4) ENSMUST00000036680.1 ENSMUST00000036680.2 ENSMUST00000036680.3 ENSMUST00000036680.4 ENSMUST00000036680.5 ENSMUST00000036680.6 ENSMUST00000036680.7 NM_175152 Q8BII6 Q8BJ25 THAP3_MOUSE uc008vyu.1 uc008vyu.2 uc008vyu.3 uc008vyu.4 Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM) (By similarity). Highest levels in heart, liver and kidney. Lower levels in brain and lung. molecular_function nucleic acid binding DNA binding cellular_component biological_process metal ion binding uc008vyu.1 uc008vyu.2 uc008vyu.3 uc008vyu.4 
ENSMUST00000036690.7 Ptchd3 ENSMUST00000036690.7 patched domain containing 3 (from RefSeq NM_029049.2) A2AC39 ENSMUST00000036690.1 ENSMUST00000036690.2 ENSMUST00000036690.3 ENSMUST00000036690.4 ENSMUST00000036690.5 ENSMUST00000036690.6 NM_029049 PTHD3_MOUSE Q0EEE2 Q9CUM1 Q9D3R2 uc007mwf.1 uc007mwf.2 uc007mwf.3 uc007mwf.4 uc007mwf.5 May play a role in sperm development or sperm function (PubMed:17904097). However, does not appear to have an essential role in spermatogenesis or male fertility (PubMed:34493359). Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Localizes to the midpiece of the sperm tail. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Ptchd3b; IsoId=Q0EEE2-1; Sequence=Displayed; Name=2; Synonyms=Ptchd3a; IsoId=Q0EEE2-2; Sequence=VSP_029100, VSP_029101; Expressed in germ cells of the testis (at protein level). Expression begins around the pachytene stage of spermatogenesis. Belongs to the patched family. membrane integral component of membrane sperm midpiece uc007mwf.1 uc007mwf.2 uc007mwf.3 uc007mwf.4 uc007mwf.5 
ENSMUST00000036691.14 Prrc2b ENSMUST00000036691.14 proline-rich coiled-coil 2B, transcript variant 2 (from RefSeq NM_172661.3) A2AN31 Bat2l Bat2l1 ENSMUST00000036691.1 ENSMUST00000036691.10 ENSMUST00000036691.11 ENSMUST00000036691.12 ENSMUST00000036691.13 ENSMUST00000036691.2 ENSMUST00000036691.3 ENSMUST00000036691.4 ENSMUST00000036691.5 ENSMUST00000036691.6 ENSMUST00000036691.7 ENSMUST00000036691.8 ENSMUST00000036691.9 Kiaa0515 NM_172661 PRC2B_MOUSE Q7TPM1 Q8C755 uc008jem.1 uc008jem.2 uc008jem.3 uc008jem.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TPM1-1; Sequence=Displayed; Name=2; IsoId=Q7TPM1-2; Sequence=VSP_022764, VSP_022765; in utero embryonic development molecular_function cellular_component uc008jem.1 uc008jem.2 uc008jem.3 uc008jem.4 
ENSMUST00000036700.7 Adra2a ENSMUST00000036700.7 Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. (from UniProt Q01338) ADA2A_MOUSE Adra2a BC138531 ENSMUST00000036700.1 ENSMUST00000036700.2 ENSMUST00000036700.3 ENSMUST00000036700.4 ENSMUST00000036700.5 ENSMUST00000036700.6 Q01338 Q3URE6 uc012bnl.1 uc012bnl.2 uc012bnl.3 Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. Q01338; Q14232: EIF2B1; Xeno; NbExp=2; IntAct=EBI-491073, EBI-491065; Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily. It is uncertain whether Met-1 or Met-16 is the initiator. Sequence=AAA37213.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAA37213.1; Type=Frameshift; Evidence=; positive regulation of cytokine production acute inflammatory response G-protein coupled receptor activity adrenergic receptor activity alpha2-adrenergic receptor activity protein binding cytoplasm plasma membrane integral component of plasma membrane DNA replication regulation of smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway female pregnancy membrane integral component of membrane regulation of vasoconstriction protein kinase binding platelet activation positive regulation of cell migration alpha-2C adrenergic receptor binding thioesterase binding activation of protein kinase activity activation of protein kinase B activity heterotrimeric G-protein binding cellular response to hormone stimulus receptor transactivation glucose homeostasis fear response protein homodimerization activity neuronal cell body receptor complex positive regulation of MAP kinase activity positive regulation of MAPK cascade axon terminus synapse positive regulation of epidermal growth factor-activated receptor activity negative regulation of calcium ion-dependent exocytosis negative regulation of insulin secretion protein heterodimerization activity thermoception negative regulation of lipid catabolic process positive regulation of membrane protein ectodomain proteolysis epinephrine binding norepinephrine binding negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of uterine smooth muscle contraction adrenergic receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-inhibiting adrenergic receptor signaling pathway phospholipase C-activating adrenergic receptor signaling pathway positive regulation of wound healing glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic active zone membrane integral component of postsynaptic density membrane regulation of synaptic vesicle exocytosis uc012bnl.1 uc012bnl.2 uc012bnl.3 
ENSMUST00000036715.16 Gm3402 ENSMUST00000036715.16 Gm3402 (from geneSymbol) ENSMUST00000036715.1 ENSMUST00000036715.10 ENSMUST00000036715.11 ENSMUST00000036715.12 ENSMUST00000036715.13 ENSMUST00000036715.14 ENSMUST00000036715.15 ENSMUST00000036715.2 ENSMUST00000036715.3 ENSMUST00000036715.4 ENSMUST00000036715.5 ENSMUST00000036715.6 ENSMUST00000036715.7 ENSMUST00000036715.8 ENSMUST00000036715.9 Gm3402 K7N5P2 K7N5P2_MOUSE uc291bty.1 uc291bty.2 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc291bty.1 uc291bty.2 
ENSMUST00000036719.12 Prex1 ENSMUST00000036719.12 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (from RefSeq NM_177782.3) A2A5U1 ENSMUST00000036719.1 ENSMUST00000036719.10 ENSMUST00000036719.11 ENSMUST00000036719.2 ENSMUST00000036719.3 ENSMUST00000036719.4 ENSMUST00000036719.5 ENSMUST00000036719.6 ENSMUST00000036719.7 ENSMUST00000036719.8 ENSMUST00000036719.9 Kiaa1415 NM_177782 PREX1_MOUSE Q69ZK0 Q6PFD4 Q8BN08 uc008nyn.1 uc008nyn.2 uc008nyn.3 Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils (By similarity). Interacts preferentially with RAC2 (PubMed:16243036). Interacts with RAC1 (PubMed:16243036). Interacts with AUTS2 (PubMed:25533347). Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69ZK0-1; Sequence=Displayed; Name=2; IsoId=Q69ZK0-2; Sequence=VSP_026436; Sequence=BAD32446.1; Type=Erroneous initiation; Evidence=; guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity phospholipid binding cytoplasm cytosol plasma membrane G-protein coupled receptor signaling pathway membrane T cell differentiation positive regulation of cell migration growth cone neutrophil chemotaxis Rac guanyl-nucleotide exchange factor activity regulation of actin filament polymerization regulation of Rho protein signal transduction intracellular signal transduction dendritic shaft positive regulation of GTPase activity positive regulation of cell adhesion perinuclear region of cytoplasm regulation of dendrite development reactive oxygen species metabolic process positive regulation of substrate adhesion-dependent cell spreading uc008nyn.1 uc008nyn.2 uc008nyn.3 
ENSMUST00000036720.9 Fkbpl ENSMUST00000036720.9 FK506 binding protein-like (from RefSeq NM_019873.3) ENSMUST00000036720.1 ENSMUST00000036720.2 ENSMUST00000036720.3 ENSMUST00000036720.4 ENSMUST00000036720.5 ENSMUST00000036720.6 ENSMUST00000036720.7 ENSMUST00000036720.8 FKBPL_MOUSE NM_019873 Ng7 O35450 Q3UKG5 uc008cdg.1 uc008cdg.2 uc008cdg.3 May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21. Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90. extracellular region regulation of angiogenesis regulation of blood vessel branching uc008cdg.1 uc008cdg.2 uc008cdg.3 
ENSMUST00000036732.9 BC016579 ENSMUST00000036732.9 cDNA sequence, BC016579, transcript variant 2 (from RefSeq NM_145389.3) BC016579 E9QP50 E9QP50_MOUSE ENSMUST00000036732.1 ENSMUST00000036732.2 ENSMUST00000036732.3 ENSMUST00000036732.4 ENSMUST00000036732.5 ENSMUST00000036732.6 ENSMUST00000036732.7 ENSMUST00000036732.8 NM_145389 uc012agh.1 uc012agh.2 uc012agh.3 membrane integral component of membrane uc012agh.1 uc012agh.2 uc012agh.3 
ENSMUST00000036734.6 Gadd45gip1 ENSMUST00000036734.6 growth arrest and DNA-damage-inducible, gamma interacting protein 1 (from RefSeq NM_183358.4) ENSMUST00000036734.1 ENSMUST00000036734.2 ENSMUST00000036734.3 ENSMUST00000036734.4 ENSMUST00000036734.5 G45IP_MOUSE Mrpl59 NM_183358 Q8BT05 Q9CR59 uc009mnj.1 uc009mnj.2 uc009mnj.3 Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with ATAD3A and ATAD3B. Mitochondrion Nucleus Note=Using N-terminally tagged constructs, has been found in the nucleus. C-terminally tagged constructs are targeted exclusively to mitochondria. This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag. Belongs to the mitochondrion-specific ribosomal protein mL64 family. nucleus mitochondrion ribosome cell cycle mitotic cell cycle arrest uc009mnj.1 uc009mnj.2 uc009mnj.3 
ENSMUST00000036737.4 Colec10 ENSMUST00000036737.4 collectin sub-family member 10 (from RefSeq NM_173422.3) COL10_MOUSE Cll1 ENSMUST00000036737.1 ENSMUST00000036737.2 ENSMUST00000036737.3 NM_173422 Q8C1C5 Q8CF98 uc007vrl.1 uc007vrl.2 Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of cell migration. Secreted Golgi apparatus Cytoplasm Expressed mainly in the liver and stomach, but also in muscles, testes, and intestines. At 16 dpc expressed in the liver, amnion and visceral yolk sac. Expression is gradually increased with embryonic age (PubMed:12450124). Expressed in the epithelium and mesenchyme of the palate shelf and jaw as early as 13.5 dpc. This particular mandibular epithelial expression is still present at 18.5 dpc (PubMed:28301481). Belongs to the COLEC10/COLEC11 family. Name=Functional Glycomics Gateway - Glycan Binding; Note=Collectin L1; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_352"; mannose binding extracellular region collagen trimer extracellular space nucleus cytoplasm Golgi apparatus cytosol defense response heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules embryo development ending in birth or egg hatching carbohydrate binding developmental process chemoattractant activity monosaccharide binding positive chemotaxis cranial skeletal system development uc007vrl.1 uc007vrl.2 
ENSMUST00000036744.8 Rbm4b ENSMUST00000036744.8 RNA binding motif protein 4B (from RefSeq NM_025717.3) ENSMUST00000036744.1 ENSMUST00000036744.2 ENSMUST00000036744.3 ENSMUST00000036744.4 ENSMUST00000036744.5 ENSMUST00000036744.6 ENSMUST00000036744.7 NM_025717 Q8VE92 RBM4B_MOUSE Rbm30 uc008gas.1 uc008gas.2 uc008gas.3 uc008gas.4 uc008gas.5 Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Interacts with TNPO3, which may mediate nuclear import of the protein. Nucleus, nucleolus Expressed in the suprachiasmatic nucleus (SCN) (at protein level). Expressed in the suprachiasmatic nucleus (SCN). Accumulates according to a circadian rhythm in the SCN. regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus nucleoplasm nucleolus cytosol mRNA processing regulation of translation circadian rhythm zinc ion binding RNA splicing positive regulation of gene expression nuclear speck circadian regulation of gene expression macromolecular complex entrainment of circadian clock by photoperiod mRNA cis splicing, via spliceosome metal ion binding uc008gas.1 uc008gas.2 uc008gas.3 uc008gas.4 uc008gas.5 
ENSMUST00000036748.15 Slc38a8 ENSMUST00000036748.15 solute carrier family 38, member 8 (from RefSeq NM_001009950.2) ENSMUST00000036748.1 ENSMUST00000036748.10 ENSMUST00000036748.11 ENSMUST00000036748.12 ENSMUST00000036748.13 ENSMUST00000036748.14 ENSMUST00000036748.2 ENSMUST00000036748.3 ENSMUST00000036748.4 ENSMUST00000036748.5 ENSMUST00000036748.6 ENSMUST00000036748.7 ENSMUST00000036748.8 ENSMUST00000036748.9 Gm587 NM_001009950 Q5HZH7 S38A8_MOUSE Slc38a8 uc009npr.1 uc009npr.2 uc009npr.3 Electrogenic sodium-dependent amino acid transporter with a preference for L-glutamine, L-alanine, L-histidine, L-aspartate and L- arginine. May facilitate glutamine uptake in both excitatory and inhibitory neurons. The transport mechanism and stoichiometry remain to be elucidated. Reaction=L-glutamine(out) = L-glutamine(in); Xref=Rhea:RHEA:73419, ChEBI:CHEBI:58359; Evidence=; Reaction=L-alanine(in) = L-alanine(out); Xref=Rhea:RHEA:70719, ChEBI:CHEBI:57972; Evidence=; Reaction=L-histidine(out) = L-histidine(in); Xref=Rhea:RHEA:72807, ChEBI:CHEBI:57595; Evidence=; Reaction=L-aspartate(out) = L-aspartate(in); Xref=Rhea:RHEA:66332, ChEBI:CHEBI:29991; Evidence=; Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143, ChEBI:CHEBI:32682; Evidence=; Reaction=L-leucine(in) = L-leucine(out); Xref=Rhea:RHEA:73011, ChEBI:CHEBI:57427; Evidence=; Membrane ; Multi- pass membrane protein Cytoplasm, cell cortex Cell projection, axon Expressed in neurons located in the gray matter. Highly expressed in thalamus, hypothalamus, amygdala and pons. Expressed in the CA3 area of hippocampus and in the Purkinje layer of the cerebellum (at protein level) (PubMed:25451601). Expressed in the eye. Belongs to the amino acid/polyamine transporter 2 family. amino acid transmembrane transport cellular_component ion transport sodium ion transport amino acid transport amino acid transmembrane transporter activity membrane integral component of membrane uc009npr.1 uc009npr.2 uc009npr.3 
ENSMUST00000036759.11 Washc2 ENSMUST00000036759.11 WASH complex subunit 2 (from RefSeq NM_026585.3) D6Wsu116e ENSMUST00000036759.1 ENSMUST00000036759.10 ENSMUST00000036759.2 ENSMUST00000036759.3 ENSMUST00000036759.4 ENSMUST00000036759.5 ENSMUST00000036759.6 ENSMUST00000036759.7 ENSMUST00000036759.8 ENSMUST00000036759.9 Fam21 Kiaa0592 NM_026585 Q3TQ99 Q6PGL7 Q80TW8 Q80UQ4 Q8CAP0 WASC2_MOUSE Washc2 uc009djs.1 uc009djs.2 uc009djs.3 uc009djs.4 Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L. Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5; in the complex interacts (via N-terminus) directly with WASHC1. The WASH core complex associates with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex. Interacts with VPS35; mediates the association with the retromer CSC complex. Interacts with FKBP15. Interacts with CCDC93, CCDC22, VPS35L; indicative for an association of the WASH core complex with the CCC and retriever complexes (By similarity). Directly interacts with TBC1D23 (PubMed:29084197). Early endosome membrane Cell membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PGL7-1; Sequence=Displayed; Name=2; IsoId=Q6PGL7-2; Sequence=VSP_030949; The LFa (leucine-phenylalanine-acidic) motif bind directly to VPS35 of retromer CSC; adjacent motifs can act cooperatively to bind multiple CSCs, although there is significant variability in the affinities of different motifs for retromer. Belongs to the FAM21 family. Sequence=AAH49979.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding nucleolus endosome early endosome cytosol plasma membrane phosphatidylinositol-5-phosphate binding protein transport membrane early endosome membrane phosphatidylinositol-3-phosphate binding protein localization to endosome retrograde transport, endosome to Golgi intracellular membrane-bounded organelle phosphatidylinositol-3,4-bisphosphate binding phosphatidylinositol-4-phosphate binding WASH complex phosphatidylinositol-3,5-bisphosphate binding retromer complex binding uc009djs.1 uc009djs.2 uc009djs.3 uc009djs.4 
ENSMUST00000036765.8 Eif4ebp3 ENSMUST00000036765.8 eukaryotic translation initiation factor 4E binding protein 3 (from RefSeq NM_201256.4) 4EBP3_MOUSE ENSMUST00000036765.1 ENSMUST00000036765.2 ENSMUST00000036765.3 ENSMUST00000036765.4 ENSMUST00000036765.5 ENSMUST00000036765.6 ENSMUST00000036765.7 NM_201256 Q2TA53 Q80VV3 uc008enx.1 uc008enx.2 uc008enx.3 uc008enx.4 Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Inhibits EIF4E-mediated mRNA nuclear export (By similarity). Interacts with EIF4E (By similarity). Interacts with RPA2 (via N-terminus); the interaction enhances EIF4EBP3-mediated inhibition of EIF4E-mediated mRNA nuclear export (By similarity). Cytoplasm Nucleus Phosphorylated. Belongs to the eIF4E-binding protein family. cytoplasm regulation of translation eukaryotic initiation factor 4E binding negative regulation of translation negative regulation of translational initiation uc008enx.1 uc008enx.2 uc008enx.3 uc008enx.4 
ENSMUST00000036796.8 Fstl4 ENSMUST00000036796.8 follistatin-like 4 (from RefSeq NM_177059.4) A2RT35 ENSMUST00000036796.1 ENSMUST00000036796.2 ENSMUST00000036796.3 ENSMUST00000036796.4 ENSMUST00000036796.5 ENSMUST00000036796.6 ENSMUST00000036796.7 FSTL4_MOUSE Kiaa1061 NM_177059 Q5DU03 Q5STE3 uc007ivp.1 uc007ivp.2 uc007ivp.3 Secreted calcium ion binding extracellular region multicellular organism development secretory granule cell differentiation negative regulation of brain-derived neurotrophic factor receptor signaling pathway metal ion binding brain-derived neurotrophic factor binding regulation of collateral sprouting negative regulation of collateral sprouting negative regulation of dendritic spine development uc007ivp.1 uc007ivp.2 uc007ivp.3 
ENSMUST00000036805.7 Plekhj1 ENSMUST00000036805.7 pleckstrin homology domain containing, family J member 1 (from RefSeq NM_023900.3) ENSMUST00000036805.1 ENSMUST00000036805.2 ENSMUST00000036805.3 ENSMUST00000036805.4 ENSMUST00000036805.5 ENSMUST00000036805.6 Gnrpx NM_023900 PKHJ1_MOUSE Q8BQ13 Q9D240 Q9EPF0 uc007ger.1 uc007ger.2 Sequence=BAC34743.1; Type=Frameshift; Evidence=; receptor recycling molecular_function early endosome trans-Golgi network cytosol endosome organization retrograde transport, endosome to Golgi recycling endosome uc007ger.1 uc007ger.2 
ENSMUST00000036807.13 Thap1 ENSMUST00000036807.13 THAP domain containing, apoptosis associated protein 1 (from RefSeq NM_199042.2) ENSMUST00000036807.1 ENSMUST00000036807.10 ENSMUST00000036807.11 ENSMUST00000036807.12 ENSMUST00000036807.2 ENSMUST00000036807.3 ENSMUST00000036807.4 ENSMUST00000036807.5 ENSMUST00000036807.6 ENSMUST00000036807.7 ENSMUST00000036807.8 ENSMUST00000036807.9 NM_199042 Q8CHW1 THAP1_MOUSE uc009lhq.1 uc009lhq.2 uc009lhq.3 uc009lhq.4 DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum- withdrawal and TNF-induced apoptosis (By similarity). Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter (By similarity). Nucleus, nucleoplasm Nucleus, PML body Highest levels in heart, liver and kidney. Lower levels in brain and lung. Belongs to the THAP1 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding fibrillar center endothelial cell proliferation nucleic acid binding DNA binding nucleus nucleoplasm transcription, DNA-templated regulation of transcription, DNA-templated cell cycle regulation of mitotic cell cycle zinc ion binding PML body identical protein binding protein homodimerization activity intracellular membrane-bounded organelle sequence-specific DNA binding metal ion binding uc009lhq.1 uc009lhq.2 uc009lhq.3 uc009lhq.4 
ENSMUST00000036819.7 Degs1l ENSMUST00000036819.7 delta 4-desaturase, sphingolipid 1 like, transcript variant 2 (from RefSeq NM_001418310.1) 9130409I23Rik Degs1l ENSMUST00000036819.1 ENSMUST00000036819.2 ENSMUST00000036819.3 ENSMUST00000036819.4 ENSMUST00000036819.5 ENSMUST00000036819.6 NM_001418310 Q3TS87 Q3TS87_MOUSE uc007dxa.1 uc007dxa.2 Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. cellular_component endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process membrane integral component of membrane oxidoreductase activity sphingolipid biosynthetic process sphingolipid delta-4 desaturase activity ceramide biosynthetic process oxidation-reduction process uc007dxa.1 uc007dxa.2 
ENSMUST00000036821.4 4930569F06Rik ENSMUST00000036821.4 4930569F06Rik (from geneSymbol) AK019794 ENSMUST00000036821.1 ENSMUST00000036821.2 ENSMUST00000036821.3 uc290yxi.1 uc290yxi.2 uc290yxi.1 uc290yxi.2 
ENSMUST00000036825.14 Sncb ENSMUST00000036825.14 synuclein, beta, transcript variant 1 (from RefSeq NM_033610.3) ENSMUST00000036825.1 ENSMUST00000036825.10 ENSMUST00000036825.11 ENSMUST00000036825.12 ENSMUST00000036825.13 ENSMUST00000036825.2 ENSMUST00000036825.3 ENSMUST00000036825.4 ENSMUST00000036825.5 ENSMUST00000036825.6 ENSMUST00000036825.7 ENSMUST00000036825.8 ENSMUST00000036825.9 NM_033610 Q91ZZ3 SYUB_MOUSE uc007qpc.1 uc007qpc.2 uc007qpc.3 May be involved in neuronal plasticity. Cytoplasm Highly expressed in the brain. Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II (By similarity). Simultaneous knockout of SNCA, SNCB and SNCG exhibit an age-dependent decrease in SNARE-complex assembly. Thus, synucleins are required for maintaining normal SNARE-complex assembly during aging in mice. Belongs to the synuclein family. calcium ion binding cytoplasm mitochondrion chemical synaptic transmission inclusion body growth cone dopamine metabolic process alpha-tubulin binding neuronal cell body terminal bouton negative regulation of neuron apoptotic process axon terminus synapse transition metal ion binding beta-tubulin binding synaptic vesicle endocytosis synapse organization presynaptic cytosol cuprous ion binding uc007qpc.1 uc007qpc.2 uc007qpc.3 
ENSMUST00000036852.9 Recql4 ENSMUST00000036852.9 RecQ protein-like 4, transcript variant 1 (from RefSeq NM_058214.4) A0A0R4J0J3 A0A0R4J0J3_MOUSE ENSMUST00000036852.1 ENSMUST00000036852.2 ENSMUST00000036852.3 ENSMUST00000036852.4 ENSMUST00000036852.5 ENSMUST00000036852.6 ENSMUST00000036852.7 ENSMUST00000036852.8 NM_058214 Recql4 uc007wlu.1 uc007wlu.2 uc007wlu.3 uc007wlu.4 Nucleus Belongs to the helicase family. RecQ subfamily. bubble DNA binding telomere maintenance DNA strand renaturation chromosome, telomeric region nucleic acid binding helicase activity ATP binding DNA replication DNA recombination zinc ion binding oxidized purine DNA binding DNA duplex unwinding annealing helicase activity 3'-5' DNA helicase activity telomeric D-loop disassembly telomeric D-loop binding uc007wlu.1 uc007wlu.2 uc007wlu.3 uc007wlu.4 
ENSMUST00000036854.4 Efhd2 ENSMUST00000036854.4 EF hand domain containing 2 (from RefSeq NM_025994.3) ENSMUST00000036854.1 ENSMUST00000036854.2 ENSMUST00000036854.3 Efhd2 NM_025994 Q8C845 Q8C845_MOUSE uc008vpl.1 uc008vpl.2 calcium ion binding uc008vpl.1 uc008vpl.2 
ENSMUST00000036858.11 Asb11 ENSMUST00000036858.11 ankyrin repeat and SOCS box-containing 11, transcript variant 1 (from RefSeq NM_001313737.1) A2AIH7 ASB11_MOUSE ENSMUST00000036858.1 ENSMUST00000036858.10 ENSMUST00000036858.2 ENSMUST00000036858.3 ENSMUST00000036858.4 ENSMUST00000036858.5 ENSMUST00000036858.6 ENSMUST00000036858.7 ENSMUST00000036858.8 ENSMUST00000036858.9 NM_001313737 Q3UJ13 Q9CQ31 Q9D0V1 uc009uvq.1 uc009uvq.2 uc009uvq.3 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQ31-1; Sequence=Displayed; Name=2; IsoId=Q9CQ31-2; Sequence=VSP_013946; The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Belongs to the ankyrin SOCS box (ASB) family. molecular_function endoplasmic reticulum protein ubiquitination intracellular signal transduction positive regulation of protein catabolic process uc009uvq.1 uc009uvq.2 uc009uvq.3 
ENSMUST00000036862.5 Cog5 ENSMUST00000036862.5 component of oligomeric golgi complex 5 (from RefSeq NM_001163126.1) COG5_MOUSE E9QM30 ENSMUST00000036862.1 ENSMUST00000036862.2 ENSMUST00000036862.3 ENSMUST00000036862.4 NM_001163126 Q8C0L8 uc007nhs.1 uc007nhs.2 Required for normal Golgi function. Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Cytoplasm, cytosol Golgi apparatus membrane ; Peripheral membrane protein Belongs to the COG5 family. Sequence=BAC27065.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane molecular_function nucleoplasm cytoplasm Golgi apparatus cytosol intra-Golgi vesicle-mediated transport protein transport membrane Golgi transport complex inter-Golgi cisterna vesicle-mediated transport uc007nhs.1 uc007nhs.2 
ENSMUST00000036865.13 Fanci ENSMUST00000036865.13 Fanconi anemia, complementation group I (from RefSeq NM_145946.2) ENSMUST00000036865.1 ENSMUST00000036865.10 ENSMUST00000036865.11 ENSMUST00000036865.12 ENSMUST00000036865.2 ENSMUST00000036865.3 ENSMUST00000036865.4 ENSMUST00000036865.5 ENSMUST00000036865.6 ENSMUST00000036865.7 ENSMUST00000036865.8 ENSMUST00000036865.9 FANCI_MOUSE NM_145946 Q8BUE9 Q8K368 Q8R3G8 uc009hyh.1 uc009hyh.2 uc009hyh.3 Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. Homodimer. Interacts with FANCD2; the interaction is direct. Interacts with FANCL. Interacts with MTMR15/FAN1. Interacts with POLN. Interacts with UBL5; the interaction promotes FANCI homodimerization. Nucleus Cytoplasm Note=Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites. They are frequently interlinked through BLM-associated ultra-fine DNA bridges (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K368-1; Sequence=Displayed; Name=2; IsoId=Q8K368-2; Sequence=VSP_026072, VSP_026073; Name=4; IsoId=Q8K368-4; Sequence=VSP_026074; The C-terminal 30 residues are probably required for function in DNA repair. Monoubiquitinated by FANCL on Lys-522 during S phase and upon genotoxic stress. Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed. Monoubiquitination requires the FANCA-FANCB- FANCC-FANCE-FANCF-FANCG-FANCM complex. Ubiquitination is required for binding to chromatin, DNA repair, and normal cell cycle progression. Monoubiquitination is stimulated by DNA-binding (By similarity). Phosphorylated in response to DNA damage by ATM and/or ATR. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=BAC39475.1; Type=Erroneous initiation; Evidence=; nucleus nucleoplasm cytosol DNA repair cellular response to DNA damage stimulus cell cycle positive regulation of protein ubiquitination Fanconi anaemia nuclear complex DNA polymerase binding uc009hyh.1 uc009hyh.2 uc009hyh.3 
ENSMUST00000036876.8 AAdacl4fm3 ENSMUST00000036876.8 AADACL4 family member 3 (from RefSeq NM_001085536.2) AAdacl4fm3 B1AVU7 B1AVU7_MOUSE ENSMUST00000036876.1 ENSMUST00000036876.2 ENSMUST00000036876.3 ENSMUST00000036876.4 ENSMUST00000036876.5 ENSMUST00000036876.6 ENSMUST00000036876.7 Gm13178 NM_001085536 uc008vrl.1 uc008vrl.2 Belongs to the 'GDXG' lipolytic enzyme family. cellular_component catabolic process membrane integral component of membrane hydrolase activity short-chain carboxylesterase activity carboxylic ester hydrolase activity uc008vrl.1 uc008vrl.2 
ENSMUST00000036877.10 Dennd2a ENSMUST00000036877.10 DENN domain containing 2A, transcript variant 1 (from RefSeq NM_172477.5) DEN2A_MOUSE ENSMUST00000036877.1 ENSMUST00000036877.2 ENSMUST00000036877.3 ENSMUST00000036877.4 ENSMUST00000036877.5 ENSMUST00000036877.6 ENSMUST00000036877.7 ENSMUST00000036877.8 ENSMUST00000036877.9 NM_172477 Q3TJU2 Q3TUG3 Q3UXA3 Q8C4S8 uc009blx.1 uc009blx.2 uc009blx.3 Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport (By similarity). Cytoplasm, cytoskeleton Note=Associated with actin filaments. Sequence=BAE22660.1; Type=Erroneous initiation; Evidence=; guanyl-nucleotide exchange factor activity cytoplasm cytosol cytoskeleton protein transport actin cytoskeleton Rab guanyl-nucleotide exchange factor activity retrograde transport, endosome to Golgi uc009blx.1 uc009blx.2 uc009blx.3 
ENSMUST00000036880.8 Cdk10 ENSMUST00000036880.8 cyclin dependent kinase 10, transcript variant 1 (from RefSeq NM_194446.2) CDK10_MOUSE ENSMUST00000036880.1 ENSMUST00000036880.2 ENSMUST00000036880.3 ENSMUST00000036880.4 ENSMUST00000036880.5 ENSMUST00000036880.6 ENSMUST00000036880.7 NM_194446 Q3UMM4 Q3UZD2 uc009nun.1 uc009nun.2 uc009nun.3 uc009nun.4 The protein encoded by this gene belongs to the CDK (cyclin-dependent kinase) subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The human ortholog has been shown to play a role in cellular proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 1. [provided by RefSeq, Jan 2010]. Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Heterodimer with CCNQ, the interaction is required for kinase activity. Interacts with ETS2. Interacts with PRK2. Cytoplasm, cytoskeleton, cilium basal body CDK10 knockout results in partial prenatal lethality. Surviving mice display severe growth retardation, a reduced volume of mineralized matrix in the head, femur, tibia and fibula, bifidity or clefting of C1 (atlas) or C2 (axis), and absence of the dens. Additional defects are present in the kidney, lung, heart, spleen, liver, and muscle. At cellular level, CDK10 knockout does not affect cell proliferation. However, knocked-out mouse embryonic fibroblasts (MEFs) develop longer cilia. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm cytoskeleton protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-threonine phosphorylation cell projection organization regulation of actin cytoskeleton organization ciliary basal body cell projection positive regulation of MAPK cascade regulation of cell cycle cyclin-dependent protein kinase activity negative regulation of cilium assembly uc009nun.1 uc009nun.2 uc009nun.3 uc009nun.4 
ENSMUST00000036884.3 Klf9 ENSMUST00000036884.3 Kruppel-like transcription factor 9 (from RefSeq NM_010638.5) Bteb1 ENSMUST00000036884.1 ENSMUST00000036884.2 Klf9 NM_010638 Q8CEC4 Q8CEC4_MOUSE uc008gzz.1 uc008gzz.2 uc008gzz.3 Nucleus nucleic acid binding nucleus nucleoplasm cytosol plasma membrane circadian rhythm negative regulation of keratinocyte proliferation cellular response to cortisol stimulus cellular response to thyroid hormone stimulus uc008gzz.1 uc008gzz.2 uc008gzz.3 
ENSMUST00000036904.7 Rnf139 ENSMUST00000036904.7 ring finger protein 139 (from RefSeq NM_175226.4) A0A0R4J0K8 A0A0R4J0K8_MOUSE ENSMUST00000036904.1 ENSMUST00000036904.2 ENSMUST00000036904.3 ENSMUST00000036904.4 ENSMUST00000036904.5 ENSMUST00000036904.6 NM_175226 Rnf139 uc007vtq.1 uc007vtq.2 uc007vtq.3 Membrane ; Multi- pass membrane protein protease binding ubiquitin-protein transferase activity endoplasmic reticulum zinc ion binding negative regulation of cell proliferation membrane integral component of membrane protein ubiquitination negative regulation of translation ubiquitin-like protein transferase activity protein destabilization ERAD pathway Derlin-1 retrotranslocation complex metal ion binding regulation of ER to Golgi vesicle-mediated transport regulation of protein processing positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc007vtq.1 uc007vtq.2 uc007vtq.3 
ENSMUST00000036928.12 Ephx1 ENSMUST00000036928.12 epoxide hydrolase 1, microsomal, transcript variant 1 (from RefSeq NM_010145.3) ENSMUST00000036928.1 ENSMUST00000036928.10 ENSMUST00000036928.11 ENSMUST00000036928.2 ENSMUST00000036928.3 ENSMUST00000036928.4 ENSMUST00000036928.5 ENSMUST00000036928.6 ENSMUST00000036928.7 ENSMUST00000036928.8 ENSMUST00000036928.9 Ephx1 HYEP_MOUSE NM_010145 P97869 Q9D379 uc007dwz.1 uc007dwz.2 uc007dwz.3 uc007dwz.4 Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity). Reaction=cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin; Xref=Rhea:RHEA:23900, ChEBI:CHEBI:15377, ChEBI:CHEBI:50004, ChEBI:CHEBI:50014; EC=3.3.2.9; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23901; Evidence=; Reaction=1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3- yl)methyl]methanamine + H2O = 2-{[(4- methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol; Xref=Rhea:RHEA:55764, ChEBI:CHEBI:15377, ChEBI:CHEBI:139161, ChEBI:CHEBI:139164; EC=3.3.2.9; Evidence=; Reaction=8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = 8,9-dihydroxy- (5Z,11Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:44048, ChEBI:CHEBI:15377, ChEBI:CHEBI:84025, ChEBI:CHEBI:84032; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44049; Evidence=; Reaction=11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = 11,12- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:44044, ChEBI:CHEBI:15377, ChEBI:CHEBI:76625, ChEBI:CHEBI:84031; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44045; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26133; Evidence=; Inhibited by 10-hydroxystearamide and methoxy- arachidonyl fluorophosphate. Microsome membrane ; Single-pass type III membrane protein Endoplasmic reticulum membrane ; Single-pass type III membrane protein Belongs to the peptidase S33 family. liver development catalytic activity epoxide hydrolase activity endoplasmic reticulum endoplasmic reticulum membrane plasma membrane cellular aromatic compound metabolic process response to toxic substance response to organic cyclic compound membrane integral component of membrane hydrolase activity aromatic compound catabolic process enzyme binding organelle membrane cis-stilbene-oxide hydrolase activity diol biosynthetic process intracellular membrane-bounded organelle cellular response to organic substance cellular response to glucocorticoid stimulus epoxide metabolic process uc007dwz.1 uc007dwz.2 uc007dwz.3 uc007dwz.4 
ENSMUST00000036937.9 Trmt12 ENSMUST00000036937.9 tRNA methyltransferase 12 (from RefSeq NM_026642.2) ENSMUST00000036937.1 ENSMUST00000036937.2 ENSMUST00000036937.3 ENSMUST00000036937.4 ENSMUST00000036937.5 ENSMUST00000036937.6 ENSMUST00000036937.7 ENSMUST00000036937.8 NM_026642 Q0P5W5 Q7TNQ8 Q8BG71 Q9D2N1 TYW2_MOUSE Tyw2 uc007vtp.1 uc007vtp.2 uc007vtp.3 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity). Reaction=4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine; Xref=Rhea:RHEA:36355, Rhea:RHEA- COMP:10164, Rhea:RHEA-COMP:10378, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789, ChEBI:CHEBI:64315, ChEBI:CHEBI:73550; EC=2.5.1.114; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family. Sequence=AAH52533.1; Type=Frameshift; Evidence=; Sequence=BAB31750.1; Type=Frameshift; Evidence=; cytoplasm tRNA processing tRNA methyltransferase activity transferase activity tRNA methylation wybutosine biosynthetic process tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity uc007vtp.1 uc007vtp.2 uc007vtp.3 
ENSMUST00000036951.13 Pebp1 ENSMUST00000036951.13 phosphatidylethanolamine binding protein 1 (from RefSeq NM_018858.2) ENSMUST00000036951.1 ENSMUST00000036951.10 ENSMUST00000036951.11 ENSMUST00000036951.12 ENSMUST00000036951.2 ENSMUST00000036951.3 ENSMUST00000036951.4 ENSMUST00000036951.5 ENSMUST00000036951.6 ENSMUST00000036951.7 ENSMUST00000036951.8 ENSMUST00000036951.9 NM_018858 Pbp Pbp1 Pebp1 Q5EBQ2 Q5EBQ2_MOUSE uc008zfl.1 uc008zfl.2 uc008zfl.3 Belongs to the phosphatidylethanolamine-binding protein family. MAPK cascade regulation of neurotransmitter levels negative regulation of protein phosphorylation regulation of the force of heart contraction receptor binding ATP binding extracellular space cytoplasm mitochondrion mitochondrial outer membrane rough endoplasmic reticulum Golgi apparatus response to oxidative stress spermatid development aging synaptic vesicle response to heat response to wounding response to toxic substance cell surface response to organic substance response to organonitrogen compound response to organic cyclic compound response to activity kinase binding protein kinase binding hippocampus development receptor serine/threonine kinase binding response to drug eating behavior neuron projection neuronal cell body negative regulation of MAPK cascade axon terminus positive regulation of cAMP-mediated signaling apical part of cell response to ethanol positive regulation of mitotic nuclear division mitogen-activated protein kinase binding response to corticosterone response to cAMP response to calcium ion response to electrical stimulus positive regulation of acetylcholine metabolic process uc008zfl.1 uc008zfl.2 uc008zfl.3 
ENSMUST00000036954.9 Gbx2 ENSMUST00000036954.9 gastrulation brain homeobox 2 (from RefSeq NM_010262.3) ENSMUST00000036954.1 ENSMUST00000036954.2 ENSMUST00000036954.3 ENSMUST00000036954.4 ENSMUST00000036954.5 ENSMUST00000036954.6 ENSMUST00000036954.7 ENSMUST00000036954.8 GBX2_MOUSE Mmoxa NM_010262 P48031 Q14A66 Stra7 uc007bzb.1 uc007bzb.2 uc007bzb.3 May act as a transcription factor for cell pluripotency and differentiation in the embryo. Nucleus Expressed in adult brain, spleen and female genital tract. No expression in heart, liver, lung, kidney, or testis. Expressed during gastrulation in the three primitive germ layers and in the pharyngeal arches. In later stages, expressed in the developing nervous system, midbrain/ hindbrain boundary, cerebellum anlage, certain rhombomeres, regions of the spinal cord, and in the developing dorsal thalamus and corpus striatum. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding branching involved in blood vessel morphogenesis neural crest cell migration DNA binding nucleus regulation of transcription, DNA-templated axon guidance cerebellum development midbrain-hindbrain boundary morphogenesis rhombomere 2 development thalamus development forebrain neuron development cerebellar granule cell precursor proliferation hindbrain development midbrain-hindbrain boundary development tube morphogenesis inner ear morphogenesis sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter autonomic nervous system development regulation of nervous system development uc007bzb.1 uc007bzb.2 uc007bzb.3 
ENSMUST00000036972.14 Armh4 ENSMUST00000036972.14 armadillo-like helical domain containing 4, transcript variant 1 (from RefSeq NM_026142.5) ARMD4_MOUSE Armh4 ENSMUST00000036972.1 ENSMUST00000036972.10 ENSMUST00000036972.11 ENSMUST00000036972.12 ENSMUST00000036972.13 ENSMUST00000036972.2 ENSMUST00000036972.3 ENSMUST00000036972.4 ENSMUST00000036972.5 ENSMUST00000036972.6 ENSMUST00000036972.7 ENSMUST00000036972.8 ENSMUST00000036972.9 NM_026142 Q8BFQ7 Q8BT18 Q8R1Q5 Q9D6C5 Ut2 uc007tkk.1 uc007tkk.2 uc007tkk.3 uc007tkk.4 May modulate immune response and may play a role in inflammation. Down-modulates STAT3 signaling throught direct interaction with IL6ST, resulting in the inhibition of phosphorylation of STAT3 at 'Tyr-705' (PubMed:26927669). May negatively regulates AKT signaling by modulating the activity of mTORC2 complex through RICTOR interaction (PubMed:25418727). Interacts with IL6ST; this interaction prevents IL6ST protein homodimerization and bridges ARMH4 with IL6R and STAT3 and therefore inhibits phosphorylation of STAT3 at 'Tyr-705' (By similarity). Interacts (via cytoplasmic tail) with RICTOR; this interaction bridges ARMH4 to the mTORC2 complex and inhibits the mTORC2 kinase activity (PubMed:25418727). Membrane ; Single- pass type I membrane protein Expressed in bone-marroew cells. Transcriptionally regulated by FOXO3. molecular_function cellular_component biological_process membrane integral component of membrane uc007tkk.1 uc007tkk.2 uc007tkk.3 uc007tkk.4 
ENSMUST00000036977.9 Mtg1 ENSMUST00000036977.9 mitochondrial ribosome-associated GTPase 1 (from RefSeq NM_199301.2) ENSMUST00000036977.1 ENSMUST00000036977.2 ENSMUST00000036977.3 ENSMUST00000036977.4 ENSMUST00000036977.5 ENSMUST00000036977.6 ENSMUST00000036977.7 ENSMUST00000036977.8 Gm169 Gtpbp7 MTG1_MOUSE NM_199301 Q3UMX2 Q3UN50 Q8R2R6 uc009khd.1 uc009khd.2 uc009khd.3 Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity). Displays mitochondrial GTPase activity (By similarity). Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent manner (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. Sequence=AAH27306.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; nucleotide binding GTPase activity GTP binding mitochondrion mitochondrial inner membrane mitochondrial matrix mitochondrial ribosome regulation of translation membrane regulation of respiratory system process regulation of mitochondrial translation uc009khd.1 uc009khd.2 uc009khd.3 
ENSMUST00000036991.5 Hspb8 ENSMUST00000036991.5 heat shock protein 8 (from RefSeq NM_030704.3) Cryac ENSMUST00000036991.1 ENSMUST00000036991.2 ENSMUST00000036991.3 ENSMUST00000036991.4 HSPB8_MOUSE Hsp22 NM_030704 Q9JK92 uc008zez.1 uc008zez.2 uc008zez.3 Displays temperature-dependent chaperone activity. Monomer. Interacts with HSPB1 (By similarity). Interacts with DNAJB6 (By similarity). Interacts with BAG3 (By similarity). Cytoplasm Nucleus Note=Translocates to nuclear foci during heat shock. Highly expressed in skeletal muscle, heart, uterus, liver, lung and ovary. Low levels found in stomach and brain. Not detected in small intestine, large intestine, kidney, spleen and testis. In the ovary, expression is concentrated in the endometrium and in the connective tissue between the circular and longitudinal muscles of the myometrium. Detected in developing heart throughout embryonic development but only detected in developing liver close to time of birth. In the adult ovary, expression is highest during decidualization and early pregnancy. By progesterone. Belongs to the small heat shock protein (HSP20) family. protein binding nucleus cytoplasm cytosol cellular response to unfolded protein identical protein binding protein homodimerization activity positive regulation of aggrephagy uc008zez.1 uc008zez.2 uc008zez.3 
ENSMUST00000036992.9 Lmo1 ENSMUST00000036992.9 LIM domain only 1, transcript variant 1 (from RefSeq NM_057173.4) ENSMUST00000036992.1 ENSMUST00000036992.2 ENSMUST00000036992.3 ENSMUST00000036992.4 ENSMUST00000036992.5 ENSMUST00000036992.6 ENSMUST00000036992.7 ENSMUST00000036992.8 NM_057173 Q924W9 RBTN1_MOUSE Rbtn1 Rhom1 Ttg1 uc009jdk.1 uc009jdk.2 uc009jdk.3 uc009jdk.4 May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. Nucleus Expressed in the brain and not in the thymus. negative regulation of transcription from RNA polymerase II promoter protein binding nucleus positive regulation of transcription from RNA polymerase II promoter regulation of T cell homeostatic proliferation metal ion binding nucleolus uc009jdk.1 uc009jdk.2 uc009jdk.3 uc009jdk.4 
ENSMUST00000036996.6 Ndufb7 ENSMUST00000036996.6 NADH:ubiquinone oxidoreductase subunit B7 (from RefSeq NM_025843.3) ENSMUST00000036996.1 ENSMUST00000036996.2 ENSMUST00000036996.3 ENSMUST00000036996.4 ENSMUST00000036996.5 NDUB7_MOUSE NM_025843 Q9CR61 uc009mkk.1 uc009mkk.2 uc009mkk.3 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Peripheral membrane protein Mitochondrion intermembrane space Contains two C-X9-C motifs that are predicted to form a helix- coil-helix structure, permitting the formation of intramolecular disulfide bonds. Belongs to the complex I NDUFB7 subunit family. molecular_function NADH dehydrogenase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial intermembrane space NADH dehydrogenase (ubiquinone) activity membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc009mkk.1 uc009mkk.2 uc009mkk.3 
ENSMUST00000037001.10 Letmd1 ENSMUST00000037001.10 LETM1 domain containing 1, transcript variant 1 (from RefSeq NM_134093.3) ENSMUST00000037001.1 ENSMUST00000037001.2 ENSMUST00000037001.3 ENSMUST00000037001.4 ENSMUST00000037001.5 ENSMUST00000037001.6 ENSMUST00000037001.7 ENSMUST00000037001.8 ENSMUST00000037001.9 LTMD1_MOUSE Letmd1 Mccr NM_134093 Q3TF05 Q3U3M7 Q8BLG9 Q8K1F7 Q8VDS9 Q924L1 uc007xri.1 uc007xri.2 uc007xri.3 uc007xri.4 Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes (PubMed:34669999, PubMed:34910916, PubMed:36334589). In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (PubMed:34910916). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (By similarity). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (PubMed:12879013). Interacts with BRI3BP. Interacts (via C-terminal) with SMARCA4; the interaction regulates transcriptional expression of thermogenic genes in brown adipose tissue (PubMed:34910916). Mitochondrion outer membrane ; Single-pass membrane protein Nucleus Mitochondrion inner membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q924L1-1; Sequence=Displayed; Name=2; IsoId=Q924L1-2; Sequence=VSP_029281; Name=3; IsoId=Q924L1-3; Sequence=VSP_029280; Highly expressed in brown adipose tissue (BAT) (PubMed:34669999, PubMed:34910916, PubMed:36334589). Also detected at low levels in white adipose tissue (PubMed:34910916). Up-regulated in white and brown adipose tissues upon cold exposure and beta-adrenergic signaling. Homozygous mice for Letmd1 gene are born at normal Mendelian ratios, with normal morphology, bodyweight and body composition at 2-months old (PubMed:34669999). Mice could not tolerate cold exposure without food (PubMed:34669999). Mutants exhibit impaired thermogenesis and are prone to diet-induced obesity and defective glucose disposal (PubMed:34910916). molecular_function nucleoplasm mitochondrion mitochondrial outer membrane membrane integral component of membrane ribosome binding uc007xri.1 uc007xri.2 uc007xri.3 uc007xri.4 
ENSMUST00000037007.4 Evpl ENSMUST00000037007.4 envoplakin (from RefSeq NM_025276.3) B1AU57 ENSMUST00000037007.1 ENSMUST00000037007.2 ENSMUST00000037007.3 EVPL_MOUSE NM_025276 Q9D952 uc007mkp.1 uc007mkp.2 uc007mkp.3 Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May form a homodimer or a heterodimer with PPL. Cell junction, desmosome Cornified envelope Cytoplasm, cytoskeleton Note=Colocalized with DSP at desmosomes and along intermediate filaments. Belongs to the plakin or cytolinker family. cornified envelope structural molecule activity cytoplasm cytosol cytoskeleton epidermis development membrane peptide cross-linking intermediate filament binding cell junction desmosome keratinocyte differentiation keratinization wound healing intermediate filament cytoskeleton organization intermediate filament cytoskeleton intermediate filament uc007mkp.1 uc007mkp.2 uc007mkp.3 
ENSMUST00000037011.6 Trim36 ENSMUST00000037011.6 tripartite motif-containing 36, transcript variant 1 (from RefSeq NM_178872.4) ENSMUST00000037011.1 ENSMUST00000037011.2 ENSMUST00000037011.3 ENSMUST00000037011.4 ENSMUST00000037011.5 NM_178872 Q7TNM1 Q80WG7 TRI36_MOUSE uc008evi.1 uc008evi.2 uc008evi.3 uc008evi.4 uc008evi.5 E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:19232519). Involved in chromosome segregation and cell cycle regulation (PubMed:19232519). May play a role in the acrosome reaction and fertilization (PubMed:12917430). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Interacts with CENPH. Cytoplasm Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasm, cytoskeleton Note=Found in the acrosomal region of elongated spermatids and mature sperm (PubMed:12917430). Colocalizes with alpha-tubulin (PubMed:19232519). Expressed in testis (PubMed:12917430). Strongly expressed in the neural tube region in 14.5 dpc embryos (PubMed:28087737). Expressed only in testicular germ cells after meiotic division. Expression was first detected at the age of 4 weeks. Belongs to the TRIM/RBCC family. Sequence=BAC76066.1; Type=Frameshift; Evidence=; mitotic cytokinesis microtubule bundle formation acrosomal vesicle ubiquitin-protein transferase activity protein binding cytoplasm cytoskeleton spindle organization acrosome reaction zinc ion binding microtubule cytoskeleton protein ubiquitination transferase activity cytoplasmic vesicle alpha-tubulin binding metal ion binding regulation of cell cycle regulation of microtubule cytoskeleton organization uc008evi.1 uc008evi.2 uc008evi.3 uc008evi.4 uc008evi.5 
ENSMUST00000037012.3 Kcna4 ENSMUST00000037012.3 potassium voltage-gated channel, shaker-related subfamily, member 4 (from RefSeq NM_021275.4) ENSMUST00000037012.1 ENSMUST00000037012.2 KCNA4_MOUSE NM_021275 Q61423 Q8CBF8 uc008llu.1 uc008llu.2 uc008llu.3 uc008llu.4 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:8020965). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:8020965). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (By similarity). Homotetramer and heterotetramer of potassium channel proteins (By similarity). Interacts with KCNAB1 and KCNAB2 (By similarity). Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity). Interacts with SIGMAR1 (By similarity). Detected in a complex with KCNA1 (By similarity). Interacts with KCNA2 (By similarity). Part of a complex containing KCNA1, KCNAB1 and LGI1 (By similarity). Interacts (via cytoplasmic N-terminal domain) with KCNRG (By similarity). Q61423; Q62108: Dlg4; NbExp=3; IntAct=EBI-2309633, EBI-300895; Cell membrane ; Multi-pass membrane protein Cell projection, axon Expressed in the brain, lens and retina. The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity protein binding endoplasmic reticulum plasma membrane integral component of plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex cell surface membrane integral component of membrane axon potassium ion binding asymmetric synapse regulation of ion transmembrane transport cell projection dendritic spine dendritic shaft protein homooligomerization transmembrane transport potassium ion transmembrane transport glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane uc008llu.1 uc008llu.2 uc008llu.3 uc008llu.4 
ENSMUST00000037014.11 Clba1 ENSMUST00000037014.11 clathrin binding box of aftiphilin containing 1 (from RefSeq NM_145450.3) CLBA1_MOUSE ENSMUST00000037014.1 ENSMUST00000037014.10 ENSMUST00000037014.2 ENSMUST00000037014.3 ENSMUST00000037014.4 ENSMUST00000037014.5 ENSMUST00000037014.6 ENSMUST00000037014.7 ENSMUST00000037014.8 ENSMUST00000037014.9 NM_145450 Q8BHN9 Q8R1Z8 uc007pfg.1 uc007pfg.2 uc007pfg.3 cytoplasm AP-1 adaptor complex clathrin binding trans-Golgi network membrane intracellular transport uc007pfg.1 uc007pfg.2 uc007pfg.3 
ENSMUST00000037023.9 Rps29 ENSMUST00000037023.9 ribosomal protein S29 (from RefSeq NM_009093.3) ENSMUST00000037023.1 ENSMUST00000037023.2 ENSMUST00000037023.3 ENSMUST00000037023.4 ENSMUST00000037023.5 ENSMUST00000037023.6 ENSMUST00000037023.7 ENSMUST00000037023.8 NM_009093 P30054 P62274 RS29_MOUSE uc007nrp.1 uc007nrp.2 uc007nrp.3 Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Component of the 40S small ribosomal subunit. Cytoplasm, cytosol Cytoplasm Rough endoplasmic reticulum Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). Belongs to the universal ribosomal protein uS14 family. cytoplasmic translation structural constituent of ribosome cytoplasm endoplasmic reticulum rough endoplasmic reticulum cytosol ribosome translation zinc ion binding cytosolic small ribosomal subunit polysomal ribosome positive regulation of apoptotic process metal ion binding cytoplasmic side of rough endoplasmic reticulum membrane uc007nrp.1 uc007nrp.2 uc007nrp.3 
ENSMUST00000037025.16 Kdm1b ENSMUST00000037025.16 lysine (K)-specific demethylase 1B, transcript variant 5 (from RefSeq NR_175317.1) Aof1 ENSMUST00000037025.1 ENSMUST00000037025.10 ENSMUST00000037025.11 ENSMUST00000037025.12 ENSMUST00000037025.13 ENSMUST00000037025.14 ENSMUST00000037025.15 ENSMUST00000037025.2 ENSMUST00000037025.3 ENSMUST00000037025.4 ENSMUST00000037025.5 ENSMUST00000037025.6 ENSMUST00000037025.7 ENSMUST00000037025.8 ENSMUST00000037025.9 KDM1B_MOUSE Kdm1b Lsd2 NR_175317 Q8C5C4 Q8CEC1 Q8CIG3 uc007qht.1 uc007qht.2 uc007qht.3 uc007qht.4 Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (PubMed:19407342, PubMed:19727073). Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (By similarity). Reaction=2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]; Xref=Rhea:RHEA:60244, Rhea:RHEA-COMP:15540, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:16842, ChEBI:CHEBI:17499, ChEBI:CHEBI:29969, ChEBI:CHEBI:61976; EC=1.14.99.66; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60245; Evidence=; Reaction=A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + L-lysyl(4)-[histone H3]; Xref=Rhea:RHEA:60256, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:16842, ChEBI:CHEBI:17499, ChEBI:CHEBI:29969, ChEBI:CHEBI:61929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60257; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit. ; Inhibited by tranylcypromine, but not by pargyline, deprenyl or rasagiline (PubMed:19407342). Histone H3K4me1 and H3K4me2 demethylase activity is inhibited by DNA, this inhibition is released in complex with GLYR1 (By similarity). Kinetic parameters: KM=9.2 uM for mono-methylated 'Lys-4' histone H3 N-terminal peptide ; KM=11.3 uM for di-methylated 'Lys-4' histone H3 N-terminal peptide ; KM=9.0 uM for mono-methylated 'Lys-4', mono-methylated 'Lys-9' histone H3 N-terminal peptide ; KM=6.6 uM for di-methylated 'Lys-4', di-methylated 'Lys-9' histone H3 N-terminal peptide ; KM=70.5 uM for mono-methylated 'Lys-4', acetylated 'Lys-9' histone H3 N-terminal peptide ; KM=8.1 uM for mono-methylated 'Lys-4', mono-methylated 'Arg-17' histone H3 N-terminal peptide ; pH dependence: Optimum pH is 8.5. ; Interacts with its cofactor GLYR1 at nucleosomes; this interaction stimulates H3K4me1 and H3K4me2 demethylation. In contrast to KDM1A, does not form a complex with RCOR1/CoREST. Nucleus Chromosome Note=Found in actively RNAPolII- transcribed gene bodies. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CIG3-1; Sequence=Displayed; Name=2; IsoId=Q8CIG3-2; Sequence=VSP_019969; Name=3; IsoId=Q8CIG3-3; Sequence=VSP_019968; Expressed in growing oocytes and in intestinal gland. No effect on mouse development and oogenesis, but embryos derived from oocytes from Kdm1b-deficient females die before mid-gestation. Histone H3 acetylation of 'Lys-9' decreases the binding of the substrate, while hyperacetylation of 'Lys-9', 'Lys-14' and 'Lys- 18', phosphorylation of 'Thr3' or 'Ser-10', and methylation of 'Arg-2' or 'Arg-8' abolishes its binding. Methylation of 'Lys-9' and 'Arg-17' are the only two epigenetic modifications that have no significant effect on catalysis. Belongs to the flavin monoamine oxidase family. Sequence=BAC26005.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC37460.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleosome nuclear chromatin DNA binding chromatin binding nucleus chromatin organization regulation of gene expression by genetic imprinting multicellular organism development transcription factor binding zinc ion binding oxidoreductase activity histone demethylase activity (H3-dimethyl-K4 specific) histone demethylase activity (H3-monomethyl-K4 specific) histone H3-K4 demethylation histone H3-K4 demethylation, trimethyl-H3-K4-specific histone binding DNA methylation involved in gamete generation regulation of DNA methylation positive regulation of transcription from RNA polymerase II promoter metal ion binding flavin adenine dinucleotide binding oxidation-reduction process FAD binding histone demethylase activity (H3-trimethyl-K4 specific) uc007qht.1 uc007qht.2 uc007qht.3 uc007qht.4 
ENSMUST00000037029.7 Jcad ENSMUST00000037029.7 junctional cadherin 5 associated (from RefSeq NM_001081963.1) ENSMUST00000037029.1 ENSMUST00000037029.2 ENSMUST00000037029.3 ENSMUST00000037029.4 ENSMUST00000037029.5 ENSMUST00000037029.6 Gm328 JCAD_MOUSE Jcad Kiaa1462 NM_001081963 Q5DTX6 uc008dyl.1 uc008dyl.2 uc008dyl.3 Cell junction, adherens junction Note=Colocalizes with CDH5/VE-Cadherin in endothelial cells but not in epithelial cells. molecular_function cell-cell junction adherens junction cell adhesion cell junction ruffle membrane positive regulation of MAPK cascade perinuclear region of cytoplasm positive regulation of cell migration involved in sprouting angiogenesis positive regulation of vascular endothelial growth factor signaling pathway positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of sprouting angiogenesis uc008dyl.1 uc008dyl.2 uc008dyl.3 
ENSMUST00000037035.12 Ripk2 ENSMUST00000037035.12 receptor (TNFRSF)-interacting serine-threonine kinase 2, transcript variant 1 (from RefSeq NM_138952.4) ENSMUST00000037035.1 ENSMUST00000037035.10 ENSMUST00000037035.11 ENSMUST00000037035.2 ENSMUST00000037035.3 ENSMUST00000037035.4 ENSMUST00000037035.5 ENSMUST00000037035.6 ENSMUST00000037035.7 ENSMUST00000037035.8 ENSMUST00000037035.9 NM_138952 Q547H1 Q547H1_MOUSE Ripk2 uc008sbr.1 uc008sbr.2 uc008sbr.3 This gene encodes a member of the receptor-interacting protein family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain, and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of nuclear factor kappa B and inducer of apoptosis in response to various stimuli. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]. Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2. Cytoplasm Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. nucleotide binding adaptive immune response immune system process protein kinase activity protein serine/threonine kinase activity receptor binding ATP binding cytoplasm cytosol cytoskeleton protein phosphorylation positive regulation of peptidyl-threonine phosphorylation positive regulation of cell death kinase activity phosphorylation transferase activity LIM domain binding positive regulation of protein ubiquitination vesicle positive regulation of protein binding macromolecular complex positive regulation of peptidyl-serine phosphorylation toll-like receptor 2 signaling pathway identical protein binding protein homodimerization activity regulation of apoptotic process positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response CARD domain binding positive regulation of interleukin-1 beta secretion positive regulation of peptidyl-tyrosine phosphorylation positive regulation of NF-kappaB transcription factor activity nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to muramyl dipeptide caspase binding activation of cysteine-type endopeptidase activity uc008sbr.1 uc008sbr.2 uc008sbr.3 
ENSMUST00000037044.13 Hace1 ENSMUST00000037044.13 HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 (from RefSeq NM_172473.3) ENSMUST00000037044.1 ENSMUST00000037044.10 ENSMUST00000037044.11 ENSMUST00000037044.12 ENSMUST00000037044.2 ENSMUST00000037044.3 ENSMUST00000037044.4 ENSMUST00000037044.5 ENSMUST00000037044.6 ENSMUST00000037044.7 ENSMUST00000037044.8 ENSMUST00000037044.9 F6VQI5 F7ALT5 HACE1_MOUSE Kiaa1320 NM_172473 Q3U0D9 Q5DTY7 Q8BXY2 Q8R160 Q8R3G4 uc007fad.1 uc007fad.2 uc007fad.3 E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens (By similarity). May also act as a transcription regulator via its interaction with RARB. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Protein modification; protein ubiquitination. Interacts with RAB1 (RAB1A, RAB1B or RAB1C), RAB4 (RAB4A or RAB4B) and RAB11 (RAB11A or RAB11B); in a GTP-dependent manner. Interacts with RAC1; in a GTP-dependent manner. Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit (By similarity). Interacts with RARB. Golgi apparatus, Golgi stack membrane Cytoplasm Endoplasmic reticulum Note=A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3U0D9-1; Sequence=Displayed; Name=2; IsoId=Q3U0D9-2; Sequence=VSP_023833, VSP_023834; Name=3; IsoId=Q3U0D9-3; Sequence=VSP_023832; Name=4; IsoId=Q3U0D9-4; Sequence=VSP_023832, VSP_042379; Mice develop spontaneous, late-onset cancer. Moreover, tumor incidence in mice heterozygous for a p53/Tp53 mutation in higher in a Hace1-deficient background. Sequence=AAH25474.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane protein polyubiquitination ubiquitin-protein transferase activity cytoplasm endoplasmic reticulum Golgi apparatus ubiquitin-dependent protein catabolic process Golgi organization cell cycle membrane protein ubiquitination nuclear body transferase activity Rab GTPase binding regulation of cell migration Golgi cisterna membrane proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process Rac GTPase binding membrane fusion ubiquitin protein ligase activity protein K48-linked ubiquitination uc007fad.1 uc007fad.2 uc007fad.3 
ENSMUST00000037048.9 Mmd2 ENSMUST00000037048.9 monocyte to macrophage differentiation-associated 2, transcript variant 5 (from RefSeq NR_184651.1) ENSMUST00000037048.1 ENSMUST00000037048.2 ENSMUST00000037048.3 ENSMUST00000037048.4 ENSMUST00000037048.5 ENSMUST00000037048.6 ENSMUST00000037048.7 ENSMUST00000037048.8 Mmd2 NR_184651 PAQRA_MOUSE Paqr10 Q8R189 uc009aix.1 uc009aix.2 uc009aix.3 uc009aix.4 Golgi apparatus membrane ; Multi- pass membrane protein Expressed in the testicular cords at 13.5 dpc. Belongs to the ADIPOR family. Golgi membrane protein kinase activity Golgi apparatus protein phosphorylation membrane integral component of membrane cytolysis regulation of protein localization positive regulation of neuron differentiation positive regulation of protein kinase activity positive regulation of Ras protein signal transduction perinuclear region of cytoplasm uc009aix.1 uc009aix.2 uc009aix.3 uc009aix.4 
ENSMUST00000037055.14 Atp13a2 ENSMUST00000037055.14 ATPase type 13A2, transcript variant 1 (from RefSeq NM_029097.3) A2AA78 AT132_MOUSE Atp13a2 ENSMUST00000037055.1 ENSMUST00000037055.10 ENSMUST00000037055.11 ENSMUST00000037055.12 ENSMUST00000037055.13 ENSMUST00000037055.2 ENSMUST00000037055.3 ENSMUST00000037055.4 ENSMUST00000037055.5 ENSMUST00000037055.6 ENSMUST00000037055.7 ENSMUST00000037055.8 ENSMUST00000037055.9 NM_029097 Q8CG98 Q9CTG6 uc008vnn.1 uc008vnn.2 uc008vnn.3 uc008vnn.4 ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine (By similarity). Also stimulates cellular uptake of polyamines and protects against polyamine toxicity (By similarity). Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (By similarity). Contributes to cellular zinc homeostasis (By similarity). Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress (By similarity). Required for proper lysosomal and mitochondrial maintenance (By similarity). Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels (PubMed:27278822). Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Promotes secretion of exosomes as well as secretion of SCNA via exosomes (By similarity). Plays a role in lipid homeostasis (By similarity). Reaction=ATP + H2O + spermidine(out) = ADP + H(+) + phosphate + spermidine(in); Xref=Rhea:RHEA:29999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57834, ChEBI:CHEBI:456216; Evidence=; Reaction=ATP + H2O + spermine(out) = ADP + H(+) + phosphate + spermine(in); Xref=Rhea:RHEA:63368, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:45725, ChEBI:CHEBI:456216; Evidence=; Accumulates in an inactive autophosphorylated state. The presence of spermine results in a dose-dependent reduction in autophosphorylation. Interacts with MYCBP2; the interaction inhibits the ubiquitination of TSC2 by MYCBP2 (By similarity). Interacts with HDAC6; the interaction results in recruitment of HDAC6 to lysosomes to promote CTTN deacetylation (By similarity). Lysosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Endosome, multivesicular body membrane ; Multi-pass membrane protein Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein The N-terminal region is required for targeting to late endosomes/lysosomes. It does not traverse the membrane but contains a membrane-embedded intramembrane domain and interacts with the lipids phosphatidic acid (PA) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). PA and PI(3,5)P2 are required for the protective effect against mitochondrial stress. Autophosphorylated. Accumulates in an inactive autophosphorylated state and autophosphorylation is stimulated by phosphatidic acid and phosphatidylinositol 3,5-bisphosphate but not by Mn(2+) or Zn(2+). The presence of spermine results in a dose-dependent reduction in autophosphorylation. No visible phenotype at 4 months (PubMed:30538141). At 10 months, gradual loss of body weight, increased liver size and reduced adipose tissue mass (PubMed:30538141). These phenotypes further progress to 18 months with significantly smaller body size, hepatomegaly, increased intracellular vacuolation in liver tissues, markedly reduced adipose tissue with small adipocytes, accumulation of autophagy receptor Sqstm1/p62 and autophagy-related protein LC3 in liver, and accumulation of ubiquitinated insoluble proteins (PubMed:30538141). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. nucleotide binding ATP binding lysosome lysosomal membrane late endosome multivesicular body autophagosome cation transport cellular calcium ion homeostasis cellular iron ion homeostasis cellular zinc ion homeostasis regulation of mitochondrion organization vesicle membrane membrane integral component of membrane regulation of macroautophagy regulation of autophagosome size hydrolase activity ATPase activity transport vesicle vesicle regulation of intracellular protein transport cellular response to oxidative stress neuron projection neuronal cell body metal ion binding positive regulation of protein secretion regulation of endopeptidase activity zinc ion homeostasis phosphatidic acid binding cellular response to manganese ion phosphatidylinositol-3,5-bisphosphate binding extracellular exosome biogenesis polyamine transmembrane transport positive regulation of exosomal secretion autophagosome organization integral component of lysosomal membrane regulation of glucosylceramidase activity regulation of lysosomal protein catabolic process peptidyl-aspartic acid autophosphorylation uc008vnn.1 uc008vnn.2 uc008vnn.3 uc008vnn.4 
ENSMUST00000037057.14 Zfp40 ENSMUST00000037057.14 zinc finger protein 40, transcript variant 1 (from RefSeq NM_009555.3) B1B1D3 B1B1D3_MOUSE ENSMUST00000037057.1 ENSMUST00000037057.10 ENSMUST00000037057.11 ENSMUST00000037057.12 ENSMUST00000037057.13 ENSMUST00000037057.2 ENSMUST00000037057.3 ENSMUST00000037057.4 ENSMUST00000037057.5 ENSMUST00000037057.6 ENSMUST00000037057.7 ENSMUST00000037057.8 ENSMUST00000037057.9 NM_009555 Zfp40 uc008asf.1 uc008asf.2 uc008asf.3 nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc008asf.1 uc008asf.2 uc008asf.3 
ENSMUST00000037059.12 Ctrc ENSMUST00000037059.12 Ctrc (from geneSymbol) BC103715 Ctrc E9QL79 E9QL79_MOUSE ENSMUST00000037059.1 ENSMUST00000037059.10 ENSMUST00000037059.11 ENSMUST00000037059.2 ENSMUST00000037059.3 ENSMUST00000037059.4 ENSMUST00000037059.5 ENSMUST00000037059.6 ENSMUST00000037059.7 ENSMUST00000037059.8 ENSMUST00000037059.9 uc290rkq.1 uc290rkq.2 serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc290rkq.1 uc290rkq.2 
ENSMUST00000037064.5 Slc25a37 ENSMUST00000037064.5 solute carrier family 25, member 37 (from RefSeq NM_026331.3) ENSMUST00000037064.1 ENSMUST00000037064.2 ENSMUST00000037064.3 ENSMUST00000037064.4 MFRN1_MOUSE Mfrn Mscp NM_026331 Q8C367 Q8CEJ7 Q91ZY0 Q920G8 Q9D2G3 Q9D547 uc029sla.1 uc029sla.2 uc029sla.3 Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. Reaction=Fe(2+)(in) = Fe(2+)(out); Xref=Rhea:RHEA:28486, ChEBI:CHEBI:29033; Evidence=; Interacts with ACB10; this interaction stabilizes SLC25A37 and enhances the function of SLC25A37 to import mitochondrial iron during erythroid differentiation. Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q920G8-1; Sequence=Displayed; Name=2; IsoId=Q920G8-2; Sequence=VSP_018411, VSP_018412; Name=3; IsoId=Q920G8-3; Sequence=VSP_018405, VSP_018410; Name=4; IsoId=Q920G8-4; Sequence=VSP_018407, VSP_018408; Name=5; IsoId=Q920G8-5; Sequence=VSP_018406, VSP_018409; Highly expressed in hematopoietic organs, fetal liver, bone marrow and spleen. In the developing embryo, it is first detected at 7.5 dpc in the extraembryonic yolk sac, coincident with the appearance of blood islands. Later, restricted expression is seen in 14.5 dpc fetal liver, the primary source of erythrocyte production in mid- gestation. Expression decreases in the spleen around 4-5 weeks of age, suggesting that it is decreased during splenic lymphocyte maturation. Erythroblasts generated from murine embryonic stem cells null for Slc25a37/Mfrn show maturation arrest with severely impaired incorporation of iron into heme. Belongs to the mitochondrial carrier (TC 2.A.29) family. Sequence=BAB29978.1; Type=Erroneous initiation; Evidence=; Sequence=BAB29978.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC25649.1; Type=Frameshift; Evidence=; iron ion transmembrane transporter activity mitochondrion mitochondrial inner membrane ion transport membrane integral component of membrane mitochondrial iron ion transport iron ion homeostasis uc029sla.1 uc029sla.2 uc029sla.3 
ENSMUST00000037097.9 Fhod3 ENSMUST00000037097.9 formin homology 2 domain containing 3, transcript variant 1 (from RefSeq NM_175276.4) B2RQR3 ENSMUST00000037097.1 ENSMUST00000037097.2 ENSMUST00000037097.3 ENSMUST00000037097.4 ENSMUST00000037097.5 ENSMUST00000037097.6 ENSMUST00000037097.7 ENSMUST00000037097.8 FHOD3_MOUSE Fhos2 Kiaa1695 NM_175276 Q5DTV7 Q76HP7 Q76LL5 Q76LL6 uc008ehb.1 uc008ehb.2 uc008ehb.3 uc008ehb.4 May play a role in actin filament polymerization in cardiomyocytes (By similarity). Actin-organizing protein that may cause stress fiber formation together with cell elongation. Interacts with nestin/NES-based interfilament (IF). Interacts with SQSTM1. Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line Note=Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining. Event=Alternative splicing; Named isoforms=4; Comment=Named isoforms=3.; Name=1; Synonyms=FHOS2L; IsoId=Q76LL6-1; Sequence=Displayed; Name=2; Synonyms=FHOS2S; IsoId=Q76LL6-2; Sequence=VSP_024400; Name=3; IsoId=Q76LL6-3; Sequence=VSP_024400, VSP_024401; Name=4; Synonyms=FHOS2M; IsoId=Q76LL6-4; Sequence=VSP_024399; Expressed in the heart, including left ventricle, kidney, brain and skeletal muscle, including soleus and tibialis anterior (at protein level). The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity). [Isoform 1]: Major form in heart. [Isoform 2]: Major form in kidney and brain. Belongs to the formin homology family. molecular_function actin binding cytoplasm cytoskeleton striated muscle thin filament actin filament organization sarcomere Z disc negative regulation of actin filament polymerization sarcomere organization actin filament network formation cardiac myofibril assembly uc008ehb.1 uc008ehb.2 uc008ehb.3 uc008ehb.4 
ENSMUST00000037099.9 Clic4 ENSMUST00000037099.9 chloride intracellular channel 4 (from RefSeq NM_013885.2) CLIC4_MOUSE ENSMUST00000037099.1 ENSMUST00000037099.2 ENSMUST00000037099.3 ENSMUST00000037099.4 ENSMUST00000037099.5 ENSMUST00000037099.6 ENSMUST00000037099.7 ENSMUST00000037099.8 NM_013885 Q8BMG5 Q9QYB1 uc008vgd.1 uc008vgd.2 uc008vgd.3 uc008vgd.4 Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3 (By similarity). May play a role in angiogenesis. Monomer. Interacts with HRH30. Interacts with AKAP9 (By similarity). Q9QYB1; P70181: Pip5k1b; NbExp=4; IntAct=EBI-645175, EBI-645167; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasmic vesicle membrane ; Single-pass membrane protein Nucleus Cell membrane ; Single-pass membrane protein Mitochondrion Cell junction Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. Might not be present in the nucleus of cardiac cells. Detected in blood vessels in the retina (at protein level). Expressed to the greatest extent in vivo in heart, lung, liver, kidney, and skin. Up-regulated by calcium ions in differentiating keratinocytes. Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as a chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity). Belongs to the chloride channel CLIC family. angiogenesis endothelial cell morphogenesis voltage-gated ion channel activity chloride channel activity protein binding nucleus cytoplasm mitochondrion centrosome cytosol plasma membrane microvillus cell-cell junction ion transport chloride transport vacuolar acidification fertilization cell surface membrane integral component of membrane nuclear matrix keratinocyte differentiation negative regulation of cell migration midbody cytoplasmic vesicle membrane cytoplasmic vesicle ion transmembrane transport chloride channel complex regulation of ion transmembrane transport multicellular organism growth macromolecular complex binding apical part of cell perinuclear region of cytoplasm branching morphogenesis of an epithelial tube retina vasculature morphogenesis in camera-type eye cellular response to calcium ion chloride transmembrane transport microtubule cytoskeleton uc008vgd.1 uc008vgd.2 uc008vgd.3 uc008vgd.4 
ENSMUST00000037115.9 Med30 ENSMUST00000037115.9 mediator complex subunit 30 (from RefSeq NM_027212.2) ENSMUST00000037115.1 ENSMUST00000037115.2 ENSMUST00000037115.3 ENSMUST00000037115.4 ENSMUST00000037115.5 ENSMUST00000037115.6 ENSMUST00000037115.7 ENSMUST00000037115.8 MED30_MOUSE NM_027212 Q9CQI9 Thrap6 Trap25 uc007vrg.1 uc007vrg.2 uc007vrg.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Q9CQI9; Q9R0X0: Med20; NbExp=2; IntAct=EBI-309220, EBI-398698; Q9CQI9; Q9D7W5: Med8; NbExp=2; IntAct=EBI-309220, EBI-7990252; Q9CQI9; Q9NVC6: MED17; Xeno; NbExp=2; IntAct=EBI-309220, EBI-394562; Q9CQI9; Q15528: MED22; Xeno; NbExp=6; IntAct=EBI-309220, EBI-394687; Q9CQI9; Q6P2C8: MED27; Xeno; NbExp=2; IntAct=EBI-309220, EBI-394603; Q9CQI9; Q9H204: MED28; Xeno; NbExp=2; IntAct=EBI-309220, EBI-514199; Q9CQI9; Q9NX70: MED29; Xeno; NbExp=2; IntAct=EBI-309220, EBI-394656; Nucleus Belongs to the Mediator complex subunit 30 family. ubiquitin ligase complex transcription cofactor activity protein binding nucleus nucleoplasm transcription initiation from RNA polymerase II promoter protein ubiquitination mediator complex stem cell population maintenance positive regulation of transcription, DNA-templated thyroid hormone receptor binding ubiquitin protein ligase activity uc007vrg.1 uc007vrg.2 uc007vrg.3 
ENSMUST00000037117.6 Gtf3c4 ENSMUST00000037117.6 general transcription factor IIIC, polypeptide 4, transcript variant 1 (from RefSeq NM_172977.3) ENSMUST00000037117.1 ENSMUST00000037117.2 ENSMUST00000037117.3 ENSMUST00000037117.4 ENSMUST00000037117.5 NM_172977 Q148Y1 Q8BKZ4 Q8BMQ2 TF3C4_MOUSE uc008ize.1 uc008ize.2 uc008ize.3 uc008ize.4 uc008ize.5 Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus- associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box (By similarity). Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BMQ2-1; Sequence=Displayed; Name=2; IsoId=Q8BMQ2-2; Sequence=VSP_010577; Name=3; IsoId=Q8BMQ2-3; Sequence=VSP_010578; Belongs to the TFIIIC subunit 4 family. transcription factor TFIIIC complex molecular_function DNA binding histone acetyltransferase activity nucleus mitochondrion biological_process histone acetylation transferase activity transferase activity, transferring acyl groups uc008ize.1 uc008ize.2 uc008ize.3 uc008ize.4 uc008ize.5 
ENSMUST00000037119.4 Dlx1 ENSMUST00000037119.4 distal-less homeobox 1, transcript variant 1 (from RefSeq NM_010053.3) DLX1_MOUSE ENSMUST00000037119.1 ENSMUST00000037119.2 ENSMUST00000037119.3 NM_010053 Q64317 uc008kau.1 uc008kau.2 uc008kau.3 uc008kau.4 The protein encoded by this gene is a homeobox-containing transcription factor involved in development. The encoded protein plays a role in craniofacial patterning, as well as in bone, placenta, and sensory organ formation. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U51001.1, SRR1660819.124789.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Plays a role as a transcriptional activator or repressor (PubMed:21875655). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (PubMed:21875655). Likely to play a regulatory role in the development of the ventral forebrain (PubMed:1676488). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (PubMed:1676488). Interacts with SMAD4 (via homeobox DNA-binding domain) (By similarity). Interacts (via homeobox DNA-binding domain) with POU4F2; this interaction suppresses DLX1-mediated transcriptional activity in postnatal retina and enhances retinal ganglion cell (RGC) differentiation (PubMed:21875655). Nucleus Expressed in a restricted region of the developing brain, within the diencephalon and the adjacent telencephalic regions. Expressed in developing retinal progenitor cells at 12 dpc (PubMed:21875655). Has a segmental expression in the developing forebrain (PubMed:1676488). The homeobox DNA-binding domain is necessary for its nuclear localization, transcriptional and erythroid differentiation activities. Belongs to the distal-less homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development proximal/distal pattern formation subpallium development hippocampus development forebrain neuron differentiation regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment cerebral cortex GABAergic interneuron differentiation cerebral cortex GABAergic interneuron fate commitment cell differentiation negative regulation of BMP signaling pathway odontogenesis of dentin-containing tooth negative regulation of neuron apoptotic process sequence-specific DNA binding positive regulation of cell differentiation negative regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter negative regulation of photoreceptor cell differentiation embryonic skeletal system development negative regulation of oligodendrocyte differentiation cellular response to transforming growth factor beta stimulus cellular response to BMP stimulus positive regulation of amacrine cell differentiation negative regulation of cellular response to transforming growth factor beta stimulus uc008kau.1 uc008kau.2 uc008kau.3 uc008kau.4 
ENSMUST00000037127.15 Eri3 ENSMUST00000037127.15 exoribonuclease 3, transcript variant 1 (from RefSeq NM_080469.5) A2ADW0 A2ADW2 ENSMUST00000037127.1 ENSMUST00000037127.10 ENSMUST00000037127.11 ENSMUST00000037127.12 ENSMUST00000037127.13 ENSMUST00000037127.14 ENSMUST00000037127.2 ENSMUST00000037127.3 ENSMUST00000037127.4 ENSMUST00000037127.5 ENSMUST00000037127.6 ENSMUST00000037127.7 ENSMUST00000037127.8 ENSMUST00000037127.9 ERI3_MOUSE NM_080469 Pint1 Prnpip Prnpip1 Q149R0 Q68FL7 Q8C460 Q923K5 uc008uis.1 uc008uis.2 uc008uis.3 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions per subunit. ; Interacts with PRNP. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C460-1; Sequence=Displayed; Name=2; IsoId=Q8C460-2; Sequence=VSP_031105, VSP_031106; Name=3; IsoId=Q8C460-3; Sequence=VSP_031107; Highly expressed in the brain, heart, thyroid and testis. Expressed at low levels in the muscle cells, liver, pancreas and kidney. 3'-5'-exoribonuclease activity exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) DNA catabolic process, exonucleolytic nucleic acid binding nuclease activity exonuclease activity protein binding plasma membrane hydrolase activity metal ion binding uc008uis.1 uc008uis.2 uc008uis.3 
ENSMUST00000037141.9 Setd7 ENSMUST00000037141.9 SET domain containing (lysine methyltransferase) 7 (from RefSeq NM_080793.6) ENSMUST00000037141.1 ENSMUST00000037141.2 ENSMUST00000037141.3 ENSMUST00000037141.4 ENSMUST00000037141.5 ENSMUST00000037141.6 ENSMUST00000037141.7 ENSMUST00000037141.8 Kiaa1717 NM_080793 Q6ZPJ6 Q80UU3 Q8C7Y6 Q8VHL1 SETD7_MOUSE Set7 Set9 uc008peb.1 uc008peb.2 uc008peb.3 Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:12711597). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (By similarity). Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:35210392). Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (By similarity). Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (By similarity). Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (PubMed:35210392). Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364; Evidence= Reaction=L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:51736, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13053, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51737; Evidence=; Interacts with IPF1/PDX-1. Nucleus Chromosome Expressed during all pre-implementation stages in both male and female embryos. The SET domain is necessary but not sufficient for histone methyltransferase activity. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily. Sequence=BAC98238.1; Type=Erroneous initiation; Evidence=; p53 binding chromatin binding protein binding nucleus chromosome nucleolus chromatin organization regulation of transcription, DNA-templated cellular response to DNA damage stimulus methyltransferase activity protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine methylation histone-lysine N-methyltransferase activity peptidyl-lysine monomethylation peptidyl-lysine dimethylation methylation histone lysine methylation response to ethanol positive regulation of transcription, DNA-templated regulation of histone H3-K9 methylation heterochromatin organization uc008peb.1 uc008peb.2 uc008peb.3 
ENSMUST00000037145.8 Cdhr2 ENSMUST00000037145.8 cadherin-related family member 2 (from RefSeq NM_001033364.3) B7ZP46 B9EJ32 CDHR2_MOUSE Cdhr2 E9Q7P9 ENSMUST00000037145.1 ENSMUST00000037145.2 ENSMUST00000037145.3 ENSMUST00000037145.4 ENSMUST00000037145.5 ENSMUST00000037145.6 ENSMUST00000037145.7 NM_001033364 Q3UN77 uc007qoz.1 uc007qoz.2 uc007qoz.3 uc007qoz.4 Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells. Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5. Interacts with MAST2 (By similarity). Interacts (via cytoplasmic domain) with USH1C and MYO7B; required for proper localization of CDHR2 to microvilli tips and its function in brush border differentiation (Probable). Apical cell membrane ; Single-pass type I membrane protein Cell projection, microvillus membrane ; Single-pass type I membrane protein Cell junction The cadherin 1 domain is required for binding to CDHR5. calcium ion binding plasma membrane integral component of plasma membrane brush border cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane apical plasma membrane cell junction cell differentiation epithelial cell differentiation brush border membrane microvillus membrane regulation of microvillus length cell projection spanning component of plasma membrane cell-cell adhesion mediated by cadherin cell adhesion molecule binding negative regulation of cell growth involved in contact inhibition intermicrovillar adhesion uc007qoz.1 uc007qoz.2 uc007qoz.3 uc007qoz.4 
ENSMUST00000037165.6 Lyl1 ENSMUST00000037165.6 lymphoblastomic leukemia 1 (from RefSeq NM_008535.2) ENSMUST00000037165.1 ENSMUST00000037165.2 ENSMUST00000037165.3 ENSMUST00000037165.4 ENSMUST00000037165.5 LYL1_MOUSE Lyl-1 NM_008535 P27792 Q4FK84 Q8BPE2 Q923F0 uc009mnb.1 uc009mnb.2 uc009mnb.3 uc009mnb.4 Efficient DNA binding requires dimerization with another bHLH protein. Nucleus RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding blood vessel maturation DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter B cell differentiation positive regulation of transcription, DNA-templated protein dimerization activity definitive hemopoiesis uc009mnb.1 uc009mnb.2 uc009mnb.3 uc009mnb.4 
ENSMUST00000037182.14 Hook3 ENSMUST00000037182.14 hook microtubule tethering protein 3 (from RefSeq NM_207659.3) ENSMUST00000037182.1 ENSMUST00000037182.10 ENSMUST00000037182.11 ENSMUST00000037182.12 ENSMUST00000037182.13 ENSMUST00000037182.2 ENSMUST00000037182.3 ENSMUST00000037182.4 ENSMUST00000037182.5 ENSMUST00000037182.6 ENSMUST00000037182.7 ENSMUST00000037182.8 ENSMUST00000037182.9 HOOK3_MOUSE NM_207659 Q540A0 Q8BUK6 Q8BV48 Q8BW57 Q8BY41 uc009lhj.1 uc009lhj.2 uc009lhj.3 Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. (Microbial infection) Serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. Self-associates (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3 (By similarity). May interact directly with AKTIP/FTS, HOOK1 and HOOK2 (By similarity). Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect (By similarity). Interacts with IIGP1 (PubMed:15075236). Interacts with MSR1, and this association is stimulated by ligand binding to MSR1 (PubMed:17237231). Interacts with microtubules. Part of a tripartite complex with dynein and dynactin, acts an adapter linking the dynein motor complex and dynactin (By similarity). Interacts with dynein intermediate chain and dynactin (DCTN1) (By similarity). Interacts with CCDC181 (PubMed:28283191). Interacts with LRGUK (PubMed:28003339). (Microbial infection) Interacts with Salmonella typhimurium spiC. Cytoplasm, cytoskeleton Golgi apparatus Note=Enriched at the cis-face of the Golgi complex (By similarity). Localizes to microtubule asters in prophase (By similarity). Localizes to the manchette in elongating spermatids (PubMed:28003339). Expressed in brain, cerebellum, heart, intestine, kidney, liver, lung, skeletal muscle, spleen and stomach (at protein level). Belongs to the hook family. pericentriolar material protein binding cytoplasm Golgi apparatus cis-Golgi network centrosome cytosol cytoskeleton microtubule endosome organization lysosome organization microtubule binding endosome to lysosome transport protein transport interkinetic nuclear migration cytoskeleton-dependent intracellular transport HOPS complex cytoplasmic microtubule organization centriolar satellite dynactin binding microtubule anchoring at centrosome identical protein binding early endosome to late endosome transport dynein light chain binding dynein intermediate chain binding negative regulation of neurogenesis Golgi localization dynein light intermediate chain binding FHF complex protein localization to centrosome neuronal stem cell population maintenance uc009lhj.1 uc009lhj.2 uc009lhj.3 
ENSMUST00000037190.15 Hpf1 ENSMUST00000037190.15 histone PARylation factor 1, transcript variant 11 (from RefSeq NR_166428.1) ENSMUST00000037190.1 ENSMUST00000037190.10 ENSMUST00000037190.11 ENSMUST00000037190.12 ENSMUST00000037190.13 ENSMUST00000037190.14 ENSMUST00000037190.2 ENSMUST00000037190.3 ENSMUST00000037190.4 ENSMUST00000037190.5 ENSMUST00000037190.6 ENSMUST00000037190.7 ENSMUST00000037190.8 ENSMUST00000037190.9 HPF1_MOUSE Hpf1 NR_166428 Q8CFE2 uc009lti.1 uc009lti.2 uc009lti.3 uc009lti.4 Cofactor for serine ADP-ribosylation that confers serine specificity on PARP1 and PARP2 and plays a key role in DNA damage response. Initiates the repair of double-strand DNA breaks: recruited to DNA damage sites by PARP1 and PARP2 and switches the amino acid specificity of PARP1 and PARP2 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins. Serine ADP-ribosylation of target proteins, such as histones, promotes decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. HPF1 acts by completing the active site of PARP1 and PARP2: forms a composite active site composed of residues from HPF1 and PARP1 or PARP2. While HPF1 promotes the initiation of serine ADP-ribosylation, it restricts the polymerase activity of PARP1 and PARP2 in order to limit the length of poly-ADP-ribose chains. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1. Interacts with PARP1 (via the PARP catalytic domain). Interacts with PARP2 (via the PARP catalytic domain). Interacts with core nucleosomes in a PARP1- and PARP2-dependent manner. Chromosome Nucleus Note=Localizes to DNA damage sites; chromatin localization is dependent on PARP1 and PARP2. Belongs to the HPF1 family. nucleus cellular response to DNA damage stimulus zinc ion binding regulation of protein ADP-ribosylation peptidyl-serine ADP-ribosylation histone binding poly-ADP-D-ribose binding uc009lti.1 uc009lti.2 uc009lti.3 uc009lti.4 
ENSMUST00000037198.10 Osgin2 ENSMUST00000037198.10 oxidative stress induced growth inhibitor family member 2, transcript variant 1 (from RefSeq NM_145950.5) BC010311 ENSMUST00000037198.1 ENSMUST00000037198.2 ENSMUST00000037198.3 ENSMUST00000037198.4 ENSMUST00000037198.5 ENSMUST00000037198.6 ENSMUST00000037198.7 ENSMUST00000037198.8 ENSMUST00000037198.9 NM_145950 Osgin2 Q3TEE9 Q3TEE9_MOUSE uc008sbp.1 uc008sbp.2 uc008sbp.3 cellular_component signal transduction growth factor activity negative regulation of cell growth uc008sbp.1 uc008sbp.2 uc008sbp.3 
ENSMUST00000037205.11 Mcee ENSMUST00000037205.11 methylmalonyl CoA epimerase, transcript variant 1 (from RefSeq NM_028626.2) ENSMUST00000037205.1 ENSMUST00000037205.10 ENSMUST00000037205.2 ENSMUST00000037205.3 ENSMUST00000037205.4 ENSMUST00000037205.5 ENSMUST00000037205.6 ENSMUST00000037205.7 ENSMUST00000037205.8 ENSMUST00000037205.9 MCEE_MOUSE Mcee NM_028626 Q9D1I5 uc009hgi.1 uc009hgi.2 uc009hgi.3 Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism. Reaction=(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA; Xref=Rhea:RHEA:20553, ChEBI:CHEBI:57326, ChEBI:CHEBI:57327; EC=5.1.99.1; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:20555; Evidence=; Mitochondrion Belongs to the methylmalonyl-CoA epimerase family. methylmalonyl-CoA epimerase activity mitochondrion isomerase activity L-methylmalonyl-CoA metabolic process metal ion binding uc009hgi.1 uc009hgi.2 uc009hgi.3 
ENSMUST00000037206.11 Agbl2 ENSMUST00000037206.11 ATP/GTP binding protein-like 2, transcript variant 2 (from RefSeq NM_001356533.1) A2AH35 Agbl2 CBPC2_MOUSE Ccp2 ENSMUST00000037206.1 ENSMUST00000037206.10 ENSMUST00000037206.2 ENSMUST00000037206.3 ENSMUST00000037206.4 ENSMUST00000037206.5 ENSMUST00000037206.6 ENSMUST00000037206.7 ENSMUST00000037206.8 ENSMUST00000037206.9 NM_001356533 Q09M08 Q09M09 Q09M10 Q09M11 Q09M12 Q8C529 Q8C9X4 Q8CDE6 Q8CDF6 Q8CDK2 Q8CDQ1 uc008ktj.1 uc008ktj.2 Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins (PubMed:25103237). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein (PubMed:25103237). Specifically cleaves tubulin long-side- chains, while it is not able to remove the branching point glutamate (PubMed:25103237). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK (PubMed:25103237). Reaction=(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L- glutamate; Xref=Rhea:RHEA:60004, Rhea:RHEA-COMP:15519, Rhea:RHEA- COMP:15675, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:143623; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60005; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Inhibited by RARRES1. Interacts with RARRES1, KIF11 and MAPRE1. Cytoplasm, cytosol Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body Note=Colocalizes with gamma-tubulin in the centrioles and with glutamylated tubulin in the basal bodies of ciliated cells. Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q8CDK2-1; Sequence=Displayed; Name=2; IsoId=Q8CDK2-2; Sequence=VSP_024366, VSP_024368; Name=3; IsoId=Q8CDK2-3; Sequence=VSP_024367, VSP_024369; Name=4; IsoId=Q8CDK2-4; Sequence=VSP_024365; Name=5; IsoId=Q8CDK2-5; Sequence=VSP_024364, VSP_024365; Name=6; IsoId=Q8CDK2-6; Sequence=VSP_024363, VSP_024366, VSP_024368; Name=7; IsoId=Q8CDK2-7; Sequence=VSP_024362, VSP_024367, VSP_024369; Widely expressed. Expressed in tissues with motile cilia such as testis, lung and trachea. Also detected in brain, eye, muscle, pancreas, intestine, stomach, pituitary, spleen, adrenal and kidney. Expressed in mitral and granular cells in brain. Up-regulated during ciliogenesis. AGBL2 and AGBL3 double mutants are viable and display no obvious phenotypic alterations. [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the peptidase M14 family. Was initially shown to catalyze the removal of carboxy- terminus tyrosine from alpha-tubulin (By similarity). However, later studies did not identified any detyrosinase or deglycylase activities from the carboxy-terminus of tubulin (PubMed:25103237). Was originally thought to have detyrosinating activity from C- terminal positions on tubulin. Sequence=ABI51945.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=ABI51946.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=ABI51947.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=ABI51948.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=ABI51949.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC37726.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAM20823.1; Type=Erroneous gene model prediction; Evidence=; carboxypeptidase activity metallocarboxypeptidase activity cytoplasm centriole cytosol cytoskeleton proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity protein side chain deglutamylation ciliary basal body cell projection metal ion binding uc008ktj.1 uc008ktj.2 
ENSMUST00000037210.9 Metap1d ENSMUST00000037210.9 methionyl aminopeptidase type 1D (mitochondrial), transcript variant 20 (from RefSeq NR_184774.1) ENSMUST00000037210.1 ENSMUST00000037210.2 ENSMUST00000037210.3 ENSMUST00000037210.4 ENSMUST00000037210.5 ENSMUST00000037210.6 ENSMUST00000037210.7 ENSMUST00000037210.8 MAP12_MOUSE Map1d Metapl1 Mnpepl NR_184774 Q80WB3 Q91YD2 Q9CPW9 uc008kas.1 uc008kas.2 uc008kas.3 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. Reaction=Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; EC=3.4.11.18; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site. ; Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CPW9-1; Sequence=Displayed; Name=2; IsoId=Q9CPW9-2; Sequence=VSP_030210; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. aminopeptidase activity mitochondrion proteolysis peptidase activity metalloexopeptidase activity hydrolase activity intracellular membrane-bounded organelle metal ion binding metalloaminopeptidase activity protein initiator methionine removal uc008kas.1 uc008kas.2 uc008kas.3 
ENSMUST00000037218.2 Rasl10a ENSMUST00000037218.2 RAS-like, family 10, member A, transcript variant 1 (from RefSeq NM_145216.4) ENSMUST00000037218.1 NM_145216 Q3KNN0 Q8K5A4 RSLAA_MOUSE Rrp22 uc007hvs.1 uc007hvs.2 uc007hvs.3 Potent inhibitor of cellular proliferation. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Cell membrane ; Lipid-anchor ; Cytoplasmic side Nucleus, nucleolus Note=May cycle in and out of the nucleolus in a GTP- dependent manner. Isoprenylation is essential for nucleolar localization, and the proliferation-inhibiting activity of RASL10A. Belongs to the small GTPase superfamily. Ras family. nucleotide binding GTPase activity GTP binding cellular_component nucleus nucleolus plasma membrane signal transduction biological_process membrane uc007hvs.1 uc007hvs.2 uc007hvs.3 
ENSMUST00000037220.5 1700028J19Rik ENSMUST00000037220.5 1700028J19Rik (from geneSymbol) 1700028J19Rik A0A0U1RNM7 A0A0U1RNM7_MOUSE AK006462 ENSMUST00000037220.1 ENSMUST00000037220.2 ENSMUST00000037220.3 ENSMUST00000037220.4 uc291pcw.1 uc291pcw.2 membrane integral component of membrane uc291pcw.1 uc291pcw.2 
ENSMUST00000037235.7 Xkr7 ENSMUST00000037235.7 X-linked Kx blood group related 7 (from RefSeq NM_001011732.1) A2ATH3 ENSMUST00000037235.1 ENSMUST00000037235.2 ENSMUST00000037235.3 ENSMUST00000037235.4 ENSMUST00000037235.5 ENSMUST00000037235.6 NM_001011732 Q5GH64 XKR7_MOUSE Xkr7 Xrg7 uc008nha.1 uc008nha.2 Cell membrane ; Multi-pass membrane protein Belongs to the XK family. molecular_function plasma membrane membrane integral component of membrane engulfment of apoptotic cell phosphatidylserine exposure on apoptotic cell surface apoptotic process involved in development uc008nha.1 uc008nha.2 
ENSMUST00000037240.3 Slc30a8 ENSMUST00000037240.3 solute carrier family 30 (zinc transporter), member 8 (from RefSeq NM_172816.4) ENSMUST00000037240.1 ENSMUST00000037240.2 NM_172816 Q8BGG0 Slc30a8 ZNT8_MOUSE Znt8 uc007vrf.1 uc007vrf.2 uc007vrf.3 Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion. Reaction=2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out); Xref=Rhea:RHEA:72627, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105; Evidence=; Homodimer. Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Associated with insulin and glucagon secretory granules. Expressed in endocrine pancreatic islet alpha and beta cells. Not detected in the brain. Knockout mice lacking Slc30a8 do not display overt developmental, morphological or behavioral phenotypes. However, a significant difference in plasma insulin concentration is observed. Each subunit of the homodimer independently transports zinc ions in a pH-dependent manner. The cytosolic pH promotes binding of zinc ions to the transporter binding site. Upon change into the organelle-facing conformation, the two histidines of the zinc-binding site get protonated at lumenal lower pH, triggering zinc release into the organelle. The transporter then moves back to the cytosolic-facing conformation where the two histidines get deprotonated at higher pH, resulting in a net antiport of 2 protons. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. Golgi membrane zinc ion transmembrane transporter activity plasma membrane ion transport cation transport zinc II ion transport cellular zinc ion homeostasis cation transmembrane transporter activity response to glucose response to zinc ion membrane integral component of membrane insulin secretion secretory granule transport vesicle membrane cytoplasmic vesicle positive regulation of insulin secretion sequestering of zinc ion response to interferon-gamma protein homodimerization activity transmembrane transport regulation of vesicle-mediated transport regulation of sequestering of zinc ion response to interleukin-1 zinc II ion transmembrane transport glucose homeostasis uc007vrf.1 uc007vrf.2 uc007vrf.3 
ENSMUST00000037246.7 Ccs ENSMUST00000037246.7 copper chaperone for superoxide dismutase, transcript variant 2 (from RefSeq NR_176927.1) CCS_MOUSE Ccs Ccsd ENSMUST00000037246.1 ENSMUST00000037246.2 ENSMUST00000037246.3 ENSMUST00000037246.4 ENSMUST00000037246.5 ENSMUST00000037246.6 NR_176927 Q9CRJ9 Q9WU84 uc008gba.1 uc008gba.2 uc008gba.3 Delivers copper to copper zinc superoxide dismutase (SOD1). Name=Cu(2+); Xref=ChEBI:CHEBI:29036; Evidence=; Note=Binds 2 copper ions per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Homodimer, and heterodimer with SOD1. Interacts with COMMD1. Interacts with XIAP/BIRC4. Interacts with SLC31A1(via C-terminal domain); this interaction is Cu(1+)-mediated. The heterodimer CCS:SOD1 interacts with SLC31A1; this heterotrimer is Cu(1+)-mediated and its maintenance is regulated through SOD1 activation. Cytoplasm Ubiquitous. Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241 (By similarity). In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. copper ion binding nucleus cytoplasm mitochondrial intermembrane space superoxide metabolic process superoxide dismutase copper chaperone activity removal of superoxide radicals enzyme binding metal ion transport metal ion binding positive regulation of oxidoreductase activity oxidation-reduction process superoxide dismutase activity uc008gba.1 uc008gba.2 uc008gba.3 
ENSMUST00000037248.10 Hirip3 ENSMUST00000037248.10 HIRA interacting protein 3, transcript variant 1 (from RefSeq NM_172746.4) ENSMUST00000037248.1 ENSMUST00000037248.2 ENSMUST00000037248.3 ENSMUST00000037248.4 ENSMUST00000037248.5 ENSMUST00000037248.6 ENSMUST00000037248.7 ENSMUST00000037248.8 ENSMUST00000037248.9 HIRP3_MOUSE Hirip3 NM_172746 Q3TSF3 Q8BLH7 uc012ftw.1 uc012ftw.2 uc012ftw.3 May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. Interacts with HIRA. Weak interaction with histones H2B and H3. Interacts with CK2 (By similarity). Nucleus Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis. Phosphorylated by CK2. molecular_function nucleus nucleolus biological_process uc012ftw.1 uc012ftw.2 uc012ftw.3 
ENSMUST00000037260.8 Zfp623 ENSMUST00000037260.8 zinc finger protein 623 (from RefSeq NM_030199.3) Bsg5 ENSMUST00000037260.1 ENSMUST00000037260.2 ENSMUST00000037260.3 ENSMUST00000037260.4 ENSMUST00000037260.5 ENSMUST00000037260.6 ENSMUST00000037260.7 NM_030199 Q9CY99 Q9CY99_MOUSE Zfp623 uc007whu.1 uc007whu.2 nucleic acid binding cellular_component uc007whu.1 uc007whu.2 
ENSMUST00000037261.4 Ptgdr2 ENSMUST00000037261.4 prostaglandin D2 receptor 2 (from RefSeq NM_009962.3) Crth2 ENSMUST00000037261.1 ENSMUST00000037261.2 ENSMUST00000037261.3 Gpr44 NM_009962 PD2R2_MOUSE Q54A00 Q9Z2J6 uc008gri.1 uc008gri.2 Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)- protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity). Cell membrane ; Multi-pass membrane protein Note=Internalized receptors colocalized with RAB11A. The 329-DSEL-332 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced internalization (By similarity). Thr-346 is a major site for PKC- induced internalization of the receptor (By similarity). Phosphorylated. Deficient mice are fertile and grew normally. Ear-swelling responses induced by hapten-specific IgE are less pronounced in deficient mice, giving 35-55% of the responses of normal mice. The reduction in cutaneous responses is associated with decreased infiltration of lymphocytes, eosinophils, and basophils and decreased production of macrophage-derived chemokine and RANTES at inflammatory sites. In models of chronic contact hypersensitivity induced by repeated hapten application, CRTH2-deficient mice result in a reduction by approximately half of skin responses and low levels (63% of control) of serum IgE production. Belongs to the G-protein coupled receptor 1 family. prostaglandin J receptor activity G-protein coupled receptor activity prostaglandin D receptor activity prostaglandin F receptor activity plasma membrane integral component of plasma membrane chemotaxis signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway neuropeptide signaling pathway membrane integral component of membrane calcium-mediated signaling peptide binding neuropeptide binding positive regulation of G-protein coupled receptor protein signaling pathway negative regulation of male germ cell proliferation uc008gri.1 uc008gri.2 
ENSMUST00000037268.6 Ccdc182 ENSMUST00000037268.6 coiled-coil domain containing 182 (from RefSeq NM_028859.1) CC182_MOUSE ENSMUST00000037268.1 ENSMUST00000037268.2 ENSMUST00000037268.3 ENSMUST00000037268.4 ENSMUST00000037268.5 NM_028859 Q9D9C6 uc011ych.1 uc011ych.2 uc011ych.3 molecular_function cellular_component biological_process female gonad development uc011ych.1 uc011ych.2 uc011ych.3 
ENSMUST00000037270.5 Fam91a1 ENSMUST00000037270.5 family with sequence similarity 91, member A1, transcript variant 1 (from RefSeq NM_145959.4) D15Ertd621e ENSMUST00000037270.1 ENSMUST00000037270.2 ENSMUST00000037270.3 ENSMUST00000037270.4 F91A1_MOUSE Kiaa0493 NM_145959 Q3UVG3 Q80TZ0 Q8K077 uc007vtn.1 uc007vtn.2 uc007vtn.3 uc007vtn.4 As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. Component of the complex WDR11 composed of C17orf75, FAM91A1 and WDR11; FAM91A1 and WDR11 are required for proper location of the complex (By similarity). Interacts with golgins GOLGA1 and GOLGA4 and with TBC1D23; interaction with golgins may be mediated by TBC1D23 and interaction with TBC1D23 recruits TBC1D23 to AP-1-derived vesicles (PubMed:29084197). Golgi apparatus, trans-Golgi network Cytoplasmic vesicle Note=Recruitment to the TGN requires the presence of GOLGA1, GOLGA4 and TBC1D23. Belongs to the FAM91 family. Sequence=AAH33609.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC65579.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function Golgi apparatus trans-Golgi network intracellular protein transport cytoplasmic vesicle vesicle tethering to Golgi uc007vtn.1 uc007vtn.2 uc007vtn.3 uc007vtn.4 
ENSMUST00000037275.6 Ccdc15 ENSMUST00000037275.6 Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8C9M2-1; Sequence=Displayed; Name=2; IsoId=Q8C9M2-2; Sequence=VSP_028797; Name=3; IsoId=Q8C9M2-3; Sequence=VSP_028797, VSP_028798, VSP_028799; Name=4; IsoId=Q8C9M2-4; Sequence=VSP_028798, VSP_028799; (from UniProt Q8C9M2) AK133297 CCD15_MOUSE ENSMUST00000037275.1 ENSMUST00000037275.2 ENSMUST00000037275.3 ENSMUST00000037275.4 ENSMUST00000037275.5 Q8BQB1 Q8BRD7 Q8C9M2 Q8CBK5 uc009oum.1 uc009oum.2 Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8C9M2-1; Sequence=Displayed; Name=2; IsoId=Q8C9M2-2; Sequence=VSP_028797; Name=3; IsoId=Q8C9M2-3; Sequence=VSP_028797, VSP_028798, VSP_028799; Name=4; IsoId=Q8C9M2-4; Sequence=VSP_028798, VSP_028799; molecular_function centrosome biological_process uc009oum.1 uc009oum.2 
ENSMUST00000037280.5 Vps18 ENSMUST00000037280.5 VPS18 CORVET/HOPS core subunit (from RefSeq NM_172269.3) ENSMUST00000037280.1 ENSMUST00000037280.2 ENSMUST00000037280.3 ENSMUST00000037280.4 NM_172269 Q8BGV6 Q8BZX6 Q8C126 Q8R307 VPS18_MOUSE uc008lto.1 uc008lto.2 uc008lto.3 Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:14517315, PubMed:22854957). Involved in dendrite development of Pukinje cells (PubMed:22699122). Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, which in HOPS further associates with VPS39 and VPS41 and in CORVET with VPS8 and TGFBRAP1. Interacts with RAB5C (PubMed:25266290). Interacts with HOOK1 (PubMed:14668490). Interacts with STX7, MON1B (By similarity). Associates with adaptor protein complex 3 (AP-3) and clathrin:AP-3 complexes (PubMed:21411634). Interacts with SYNPO2 (By similarity). Interacts with PLEKHM1 (By similarity). Q8R307; Q9H9C1: VIPAS39; Xeno; NbExp=5; IntAct=EBI-2527788, EBI-749080; Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Early endosome Cytoplasmic vesicle, autophagosome Cytoplasmic vesicle, clathrin-coated vesicle Note=Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes. Belongs to the VPS18 family. actin binding protein binding lysosome lysosomal membrane endosome early endosome late endosome autophagosome actin filament intracellular protein transport vesicle docking involved in exocytosis autophagy endosome organization vacuole organization lysosome organization endosome to lysosome transport protein transport membrane vesicle-mediated transport syntaxin binding clathrin-coated vesicle protein binding, bridging HOPS complex cytoplasmic vesicle late endosome membrane CORVET complex regulation of SNARE complex assembly viral entry into host cell metal ion binding presynapse glutamatergic synapse regulation of synaptic vesicle exocytosis AP-3 adaptor complex uc008lto.1 uc008lto.2 uc008lto.3 
ENSMUST00000037285.10 Git1 ENSMUST00000037285.10 GIT ArfGAP 1, transcript variant 1 (from RefSeq NM_001004144.1) ENSMUST00000037285.1 ENSMUST00000037285.2 ENSMUST00000037285.3 ENSMUST00000037285.4 ENSMUST00000037285.5 ENSMUST00000037285.6 ENSMUST00000037285.7 ENSMUST00000037285.8 ENSMUST00000037285.9 GIT1_MOUSE NM_001004144 Q68FF6 uc007kgy.1 uc007kgy.2 uc007kgy.3 GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase. Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (By similarity). May promote cell motility both by regulating focal complex dynamics and by the activation of RAC1 (By similarity). May act as scaffold for MAPK1/3 signal transduction, recruiting MAPK1/3 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (By similarity). Plays a role in brain development and function (PubMed:25792865, PubMed:33010377). Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (PubMed:20043896, PubMed:29554125). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (By similarity). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (PubMed:21499268). Required for successful bone regeneration during fracture healing (PubMed:25138700, PubMed:24586541, PubMed:32460388). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (PubMed:32460388). May play a role in angiogenesis during fracture healing (PubMed:24586541, PubMed:31502302). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (By similarity). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). Forms homodimers and possibly oligomers (By similarity). May forms heterooligomers with GIT2 (By similarity). Interacts with G protein-coupled receptor kinases, including GRK2, GRK3, GRK5 and GRK6 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA4 (By similarity). Interacts with GRIP1 and forms a ternary complex with PPFIA1 and GRIP1 (By similarity). Directly interacts with ARHGEF7/beta- PIX, forming in vitro a heptameric complex made of a GIT1 dimer and an ARHGEF7 trimer (By similarity). Directly interacts with PXN/paxillin; this interaction is enhanced in the presence of ARHGEF7 (By similarity). Directly interacts (via C-terminus) with TGFB1I1/Hic-5 (via LD motif 3) (PubMed:12153727). Directly interacts with PTK2/FAK1 (By similarity). May interact with PTK2B/PYK2; this interaction may be indirect (By similarity). Interacts with AMPA receptors GRIA2/3 (By similarity). Directly interacts with protein Piccolo/PCLO (By similarity). Forms a complex with Ephrin-B1/EFNB1 and NCK2/GRB4 (via SH2); this interaction is important for spine morphogenesis and synapse formation. Interaction with NCK2 is transient and depends upon GIT1 phosphorylation at Tyr-392 (PubMed:17310244). Interacts with GRIN3A/GluN3A (via C-terminus); this interaction competes with GIT1 interaction with ARHGEF7 and limits synaptic localization of GIT1 (PubMed:24297929). Interacts with IKBKG/NEMO in resting bone mesenchymal stem cells, as well as in TNF-stimulated cells; this interaction may increase IKBKG affinity for 'Lys-63'-linked polyubiquitin chains (By similarity). Interacts with GABA(A) receptors, including GABRB3 and GABRG2 (By similarity). Interacts with SCRIB (PubMed:15182672). Interacts (via N- and C-terminus) with ENTR1/SDCCAG3 (via N-terminus); this interaction is direct (PubMed:23108400). May form a tripartite complex with ENTR1 and PTPN13 (By similarity). Interacts with YWHAZ (PubMed:16959763). Interacts with PAK1 (By similarity). Interacts with PAK3 (By similarity). Directly interacts (via N-terminus) with gamma-tubulin (By similarity). Interacts with MAPK1 and MAPK3; this interaction is required for MAPK1/3 recruitment to focal adhesions (PubMed:15923189). Q68FF6; Q9ES28: Arhgef7; NbExp=2; IntAct=EBI-645933, EBI-642580; Cytoplasm Presynapse Postsynapse Postsynaptic density Cell junction, focal adhesion Cell projection, lamellipodium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Note=Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytosolic complexes, containing at least PXN/paxillin, ARHGEF7 and PAK1, and membrane protrusions. During cell migration, moves from the disassembling adhesions into the cytosol and towards the leading edge. In adherent cells, localizes to adhesions. Recruitment to adhesions may be mediated by RAC1 and active tyrosine- phosphorylated PXN (By similarity). May be present in both excitatory and inhibitory synapses. In hippocampal neurons, recruitment of GIT1 to synapses is regulated by ephrinB activation and ephrinB downstream effector GRB4/NCK2. In hippocampal neurons, partially colocalizes with PCLO (By similarity). Interaction with GRIN3A limits GIT1 synaptic localization (By similarity). Localization to the centrosome does not depend upon the presence of gamma-tubulin (By similarity). Expressed in the brain (at protein level) (PubMed:15182672, PubMed:16959763, PubMed:17310244, PubMed:19273721, PubMed:19383529, PubMed:21499268, PubMed:24297929). Also expressed at high levels in lung and heart (PubMed:19273721). In lung, expressed in endothelial cells, especially in capillaries; also expressed in smooth muscle and epithelial cells of bronchi (at protein level) (PubMed:19273721). Expressed in bone marrow mesenchymal stem cells, as well as in osteoclasts and bone marrow-derived macrophages (at protein level) (PubMed:25138700, PubMed:32460388). In lung, up-regulated from postnatal day 3 (P3). Expression levels decrease after P5 and at P25, they are similar to those observed at P0 (PubMed:19273721). During the fracture healing process, expression is strongly up-regulated in the healing callus 14 days after the lesion and remains highly expressed at day 21 (PubMed:24586541). Phosphorylated on tyrosine residues by PTK2/FAK1 and SRC in growing fibroblasts. Phosphorylation at Tyr-392 is induced by activation of Ephrin-B1/EFNB1 and catalyzed by SRC family kinases. It is required for the interaction with NCK2 and for GIT1 recruitment to synapses in hippocampal neurons. Knockout mice are born at the expected Mendelian ratio, but have decreased survival compared to wild-type littermates, with about 50% of mutant mice dying postnatally. Surviving animals develop normally and are fertile (PubMed:19273721, PubMed:19383529, PubMed:21499268, PubMed:33010377). They are however 60-70% smaller than wild-type littermates (PubMed:21499268). A major abnormality in knockout mice is impaired lung development, characterized by markedly reduced numbers of pulmonary blood vessels and increased alveolar spaces (PubMed:19273721). Although knockout mice show an unaltered brain gross morphology and neuronal density, they display microcephaly, with an overall brain size about 32% smaller compared to wild-type controls. This phenotype may be due to smaller neuronal size, rather than reduced neuron number, compared to wild-type littermates (PubMed:20043896, PubMed:25792865, PubMed:33010377). Mutant mice exhibit reduced dendritic length and spine density in the hippocampus and the cortex, which may lead to poor adaptation to new environments and impaired fear response (PubMed:19383529, PubMed:20043896, PubMed:25792865, PubMed:29554125). This effect on the brain is not uniform. Multiple brain regions suffer local atrophy, including extensive areas of the cortex, thalamus, and hippocampus, white matter tracts have a reduced volume, most notably in the anterior commissure, but also in the cerebral peduncle, fornix, and spinal trigeminal tract. On the other hand, local hypertrophy is detected in the basal ganglia, the accumbens, caudate putamen, and amygdala, as well as in the cortical layer IV, and cerebellum (PubMed:33010377). The analysis of a genetrap mouse strain lacking GIT1 showed phenotypic traits similar to attention deficit-hyperactivity disorder (ADHD), including hyperactivity, impaired learning and memory, and enhanced theta rhythms. These phenotypic traits could be reversed by amphetamines and methylphenidate (PubMed:21499268, PubMed:26113791). Abnormal thalamic oscillations, cortical theta rhythms and behavioral hyperactivity were also normalized by ethosuximide (PubMed:26113791). The abnormal behaviors decreased with age (PubMed:21499268). ADHD phenotype and response to amphetamines were not seen in other knockout mouse models (PubMed:29554125). Mutant animals show altered gait (PubMed:25792865). They exhibit defects in motor coordination and motor learning in rotarod test and abnormal spatial learning and memory (PubMed:25792865, PubMed:29554125). Knockout mice exhibit delayed bone fracture healing process. They display a persistence of cartilagenous callus and decreased chondrocyte proliferation and apoptosis, leading to their accumulation in the fracture area (PubMed:25138700, PubMed:24586541). The healing callus exhibits reduced blood vessel volume and number, as well as a reduced osteoclast number (PubMed:24586541, PubMed:31502302). immunological synapse formation GTPase activator activity protein binding cytoplasm endosome cytosol focal adhesion regulation of G-protein coupled receptor protein signaling pathway small GTPase binding negative regulation of ARF protein signal transduction regulation of cytokinesis protein homodimerization activity neuron projection positive regulation of GTPase activity calyx of Held macromolecular complex binding synapse metal ion binding ephrin receptor signaling pathway dendritic spine development cellular response to epidermal growth factor stimulus postsynapse structural constituent of postsynaptic specialization maintenance of postsynaptic specialization structure glutamatergic synapse GABA-ergic synapse neurotransmitter receptor localization to postsynaptic specialization membrane regulation of synaptic vesicle exocytosis positive regulation of receptor catabolic process uc007kgy.1 uc007kgy.2 uc007kgy.3 
ENSMUST00000037286.12 C1ql2 ENSMUST00000037286.12 complement component 1, q subcomponent-like 2 (from RefSeq NM_207233.1) C1QL2_MOUSE C1qtnf10 Ctrp10 ENSMUST00000037286.1 ENSMUST00000037286.10 ENSMUST00000037286.11 ENSMUST00000037286.2 ENSMUST00000037286.3 ENSMUST00000037286.4 ENSMUST00000037286.5 ENSMUST00000037286.6 ENSMUST00000037286.7 ENSMUST00000037286.8 ENSMUST00000037286.9 NM_207233 Q8CFR0 uc007cjk.1 uc007cjk.2 May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Forms homotrimers which can further assemble to form higher- order oligomeric complexes. Interacts with ADGRB3. May interact with ERFE. Forms heterooligomers with C1QL3 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion. Secreted Highest expression in eye, followed by placenta and brain, intermediate expression in adipose tissue and lowest expression in lymph node and testis. Glycosylated, but not with N-linked glycans. protein binding extracellular region collagen trimer macromolecular complex identical protein binding uc007cjk.1 uc007cjk.2 
ENSMUST00000037287.8 Cdkn1c ENSMUST00000037287.8 cyclin dependent kinase inhibitor 1C, transcript variant 2 (from RefSeq NM_009876.5) Cdkn1c ENSMUST00000037287.1 ENSMUST00000037287.2 ENSMUST00000037287.3 ENSMUST00000037287.4 ENSMUST00000037287.5 ENSMUST00000037287.6 ENSMUST00000037287.7 NM_009876 Q791X1 Q791X1_MOUSE p57Kip2 uc009kpd.1 uc009kpd.2 uc009kpd.3 uc009kpd.4 Nucleus Belongs to the CDI family. cyclin-dependent protein serine/threonine kinase inhibitor activity nucleus cell cycle arrest regulation of mitotic cell cycle kinase activity phosphorylation negative regulation of cyclin-dependent protein serine/threonine kinase activity uc009kpd.1 uc009kpd.2 uc009kpd.3 uc009kpd.4 
ENSMUST00000037290.12 Mars1 ENSMUST00000037290.12 methionine-tRNA synthetase 1, transcript variant 2 (from RefSeq NM_001003913.2) ENSMUST00000037290.1 ENSMUST00000037290.10 ENSMUST00000037290.11 ENSMUST00000037290.2 ENSMUST00000037290.3 ENSMUST00000037290.4 ENSMUST00000037290.5 ENSMUST00000037290.6 ENSMUST00000037290.7 ENSMUST00000037290.8 ENSMUST00000037290.9 Mars NM_001003913 Q68FL6 SYMC_MOUSE uc007hiz.1 uc007hiz.2 uc007hiz.3 The encoded protein belongs to the class I family of tRNA synthetases, a class of enzymes that charge tRNAs with their cognate amino acids. The related human gene product is essential for the translation initiation of mRNAs. This gene has an overlapping 3' UTR tail-to-tail arrangement with an adjacent gene on the opposite strand that encodes an inhibitor of the CCAAT/enhancer-binding protein's DNA binding activity. This arrangement, conserved in human and mouse, may be involved in mRNA stability and possible functional and regulatory interaction of these adjacent overlapping genes. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus. Reaction=ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L- methionyl-tRNA(Met); Xref=Rhea:RHEA:13481, Rhea:RHEA-COMP:9667, Rhea:RHEA-COMP:9698, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530, ChEBI:CHEBI:456215; EC=6.1.1.10; Evidence=; Monomer. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18. Forms a linear complex that contains MARS1, EEF1E1, EPRS1 and AIMP2 that is at the core of the multisubunit complex. Cytoplasm, cytosol Nucleus, nucleolus Note=Localizes to the nucleolus in proliferative cells but disappears in quiescent cells. Belongs to the class-I aminoacyl-tRNA synthetase family. tRNA binding nucleotide binding RNA binding aminoacyl-tRNA ligase activity methionine-tRNA ligase activity ATP binding nucleus nucleolus cytoplasm mitochondrion cytosol translation tRNA aminoacylation for protein translation methionyl-tRNA aminoacylation cellular response to starvation rRNA transcription ligase activity aminoacyl-tRNA synthetase multienzyme complex cellular response to insulin stimulus cellular response to platelet-derived growth factor stimulus cellular response to epidermal growth factor stimulus positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter uc007hiz.1 uc007hiz.2 uc007hiz.3 
ENSMUST00000037294.8 Tfap2d ENSMUST00000037294.8 transcription factor AP-2, delta, transcript variant 1 (from RefSeq NM_153154.3) A7MCU6 AP2D_MOUSE ENSMUST00000037294.1 ENSMUST00000037294.2 ENSMUST00000037294.3 ENSMUST00000037294.4 ENSMUST00000037294.5 ENSMUST00000037294.6 ENSMUST00000037294.7 NM_153154 Q91ZK0 Tcfap2d uc007akp.1 uc007akp.2 uc007akp.3 uc007akp.4 Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Q91ZK0; Q91X20: Ash2l; NbExp=4; IntAct=EBI-15703453, EBI-1556554; Nucleus Expressed in both embryonic and newborn brain. Expression is first detected at 9.5 dpc in the central nervous system and the developing heart. The signal detected in heart persists through to 10.5 dpc. Diffusely expressed in developing brain at 10.5 dpc to 11.5 dpc, but by 13.5 dpc expression is mostly confined to the midbrain and forebrain. Also expressed in the spinal cord at 10.5 dpc, and in retinal epithelium from 13.5 dpc to 16.5 dpc. No signals detected in tissues such as the neural crest, facial mesenchyme, and limbs where other Tfap2 genes are expressed. Belongs to the AP-2 family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter negative regulation of neuron apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter inferior colliculus development uc007akp.1 uc007akp.2 uc007akp.3 uc007akp.4 
ENSMUST00000037297.4 Ssxb1 ENSMUST00000037297.4 SSX member B1 (from RefSeq NM_026492.4) ENSMUST00000037297.1 ENSMUST00000037297.2 ENSMUST00000037297.3 NM_026492 Q9CPU1 Q9CPU1_MOUSE Ssxb1 uc009sox.1 uc009sox.2 Belongs to the SSX family. nucleic acid binding nucleus regulation of transcription, DNA-templated uc009sox.1 uc009sox.2 
ENSMUST00000037299.15 Ythdf1 ENSMUST00000037299.15 YTH N6-methyladenosine RNA binding protein 1 (from RefSeq NM_173761.3) ENSMUST00000037299.1 ENSMUST00000037299.10 ENSMUST00000037299.11 ENSMUST00000037299.12 ENSMUST00000037299.13 ENSMUST00000037299.14 ENSMUST00000037299.2 ENSMUST00000037299.3 ENSMUST00000037299.4 ENSMUST00000037299.5 ENSMUST00000037299.6 ENSMUST00000037299.7 ENSMUST00000037299.8 ENSMUST00000037299.9 NM_173761 P59326 Q3T9E2 YTHD1_MOUSE Ythdf1 uc008okd.1 uc008okd.2 uc008okd.3 Specifically recognizes and binds N6-methyladenosine (m6A)- containing mRNAs, and regulates their stability (PubMed:30401835, PubMed:32943573). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:30401835, PubMed:32943573). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (By similarity). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:32943573). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (PubMed:30401835). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (PubMed:30843071). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (PubMed:30728504). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (PubMed:30728504). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (By similarity). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (By similarity). Interacts with CNOT1; promoting recruitment of the CCR4-NOT complex (By similarity). Interacts with ribosomes (By similarity). Interacts with eIF3 (EIF3A or EIF3B). Interacts with YTHDF3 (By similarity). Cytoplasm Cytoplasm, P-body Cytoplasm, Stress granule In brain, preferentially expressed in the hippocampus. The disordered regions have the ability to interact with each other and to 'phase separate' into liquid droplets within the cytosol following binding to mRNAs containing multiple m6A-modified residues. This leads to the partition of m6A-containing mRNAs into membraneless compartments, where mRNAs may be stored, degraded or used to transport mRNAs to dendritic arbors in neurons. Mice are viable and were born at the expected Mendelian ratio (PubMed:32943573). They however display learning and memory defects (PubMed:30401835). Mice develop normally up to four months of age and have normal gross hippocampal histology (PubMed:30401835). They however show learning and memory defects as well as impaired hippocampal synaptic transmission and long-term potentiation (PubMed:30401835). Hippocampal CA1 neurons show reduced dendritic spine density but unaltered spine size (PubMed:30401835). Conditional deletion in spinal commissural neurons results in pre- crossing axon guidance defects (PubMed:30843071). Knockout mice show an improved tumor control associated with increased infiltration of the tumor by T-cells, due to elevated antigen-specific CD8(+) T-cell anti- tumor response (PubMed:30728504). Conditional deletion in myeloid dendritic cells causes increased cross-presentation of tumor antigens and the cross-priming of CD8(+) T-cells (PubMed:30728504). Mice lacking Ythdf1, Ythdf2 and Ythdf3 display early embryonic lethality and show defects in embryonic stem cell differentiation (PubMed:32943573). Belongs to the YTHDF family. YTHDF1 subfamily. Was initially reported to act as a regulator of mRNA translation efficiency by promoting ribosome loading to m6A-containing mRNAs and by interacting with translation initiation factors eIF3 (EIF3A or EIF3B), thereby facilitating translation initiation (PubMed:30401835, PubMed:30728504, PubMed:30843071). These studies suggested that the 3 different paralogs (YTHDF1, YTHDF2 and YTHDF3) have unique functions with limited redundancy (PubMed:30401835, PubMed:30728504, PubMed:30843071). However, later studies showed that YTHDF1, YTHDF2 and YTHDF3 paralogs have redundant functions to a profound extent and directly promote degradation of m6A-containing mRNAs (PubMed:32943573). The effect on translation efficiency observed earlier is probably indirect (PubMed:32943573). immune system process regulation of antigen processing and presentation RNA binding cellular_component cytoplasm learning memory ribosome binding positive regulation of translation positive regulation of translational initiation regulation of long-term synaptic potentiation regulation of axon guidance N6-methyladenosine-containing RNA binding uc008okd.1 uc008okd.2 uc008okd.3 
ENSMUST00000037302.6 Tbc1d12 ENSMUST00000037302.6 TBC1D12: TBC1 domain family, member 12, transcript variant 3 (from RefSeq NR_175806.1) E9QQ68 E9QQ68_MOUSE ENSMUST00000037302.1 ENSMUST00000037302.2 ENSMUST00000037302.3 ENSMUST00000037302.4 ENSMUST00000037302.5 NR_175806 Tbc1d12 uc008hjs.1 uc008hjs.2 uc008hjs.1 uc008hjs.2 
ENSMUST00000037315.13 Abhd2 ENSMUST00000037315.13 abhydrolase domain containing 2 (from RefSeq NM_018811.6) ABHD2_MOUSE ENSMUST00000037315.1 ENSMUST00000037315.10 ENSMUST00000037315.11 ENSMUST00000037315.12 ENSMUST00000037315.2 ENSMUST00000037315.3 ENSMUST00000037315.4 ENSMUST00000037315.5 ENSMUST00000037315.6 ENSMUST00000037315.7 ENSMUST00000037315.8 ENSMUST00000037315.9 Labh-2 Labh2 NM_018811 Q3U5E8 Q5FWC6 Q9D7Y8 Q9QXM0 uc009hyc.1 uc009hyc.2 uc009hyc.3 Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). Involved in acrosomal reaction (Probable). May also play a role in smooth muscle cells migration (PubMed:15721306). Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.; EC=3.1.1.23; Evidence=; Reaction=an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+); Xref=Rhea:RHEA:12957, ChEBI:CHEBI:2571, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:47622; EC=3.1.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12958; Evidence=; Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.79; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12045; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26133; Evidence=; Reaction=a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+); Xref=Rhea:RHEA:47348, ChEBI:CHEBI:2571, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:50477; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47349; Evidence=; Reaction=H2O + hexadecanoate ester = an aliphatic alcohol + H(+) + hexadecanoate; Xref=Rhea:RHEA:47392, ChEBI:CHEBI:2571, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25835; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47393; Evidence=; Acylglycerol lipase activity is activated upon binding to progesterone. Cell membrane ; Single-pass type II membrane protein Cytoplasmic vesicle, secretory vesicle, acrosome membrane Note=Absent from the sperm flagellum. Widely expressed with higher expression in testis. Expressed by vascular smooth muscle cells, non vascular smooth muscle cells and heart. Detected in embryos from 7 dpc to 17 dpc. Weakly expressed in heart at 9.5 dpc. Expression is detected in endothelial cells of the dorsal aorta at 10.5 dpc and disappear at 12.5 dpc. Expression in smooth muscle cells is first detected at 11.5 dpc. Strongly expressed in vitelline vessels at 12.5 dpc. Expressed in all smooth muscle cells at 16.5 dpc. Neointimal hyperplasia (PubMed:15721306). In lungs, decreased level of phosphatidylcholine in the bronchoalveolar lavage is observed (PubMed:19250629). Mice develop spontaneous gradual progression of emphysema (PubMed:19250629). Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. acrosomal vesicle acrosomal membrane steroid hormone receptor activity plasma membrane lipid metabolic process acrosome reaction acetylesterase activity response to wounding membrane integral component of membrane lipid catabolic process lipase activity hydrolase activity negative regulation of cell migration cytoplasmic vesicle response to progesterone hormone-sensitive lipase activity sperm flagellum hormone binding steroid hormone mediated signaling pathway cellular lipid metabolic process acylglycerol catabolic process acylglycerol lipase activity sperm capacitation carboxylic ester hydrolase activity sperm plasma membrane uc009hyc.1 uc009hyc.2 uc009hyc.3 
ENSMUST00000037321.8 Slc7a12 ENSMUST00000037321.8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 (from RefSeq NM_080852.3) ENSMUST00000037321.1 ENSMUST00000037321.2 ENSMUST00000037321.3 ENSMUST00000037321.4 ENSMUST00000037321.5 ENSMUST00000037321.6 ENSMUST00000037321.7 NM_080852 Q8R2J1 Q8VIE6 S7A12_MOUSE Slc7a12 uc008oqg.1 uc008oqg.2 uc008oqg.3 uc008oqg.4 Probably mediates sodium- and chloride-independent uptake of neutral amino acids. Probably forms multimers, perhaps with an unknown protein(s). Apical cell membrane ; Multi-pass membrane protein Basal cell membrane ; Multi-pass membrane protein Cytoplasm Expressed in kidney and red blood cells (at protein level) (PubMed:11591708). Expressed in kidney along the collecting ducts in the cortex, outer and inner medulla (PubMed:11591708, PubMed:11943479). May be expressed in placenta, lungs, spleen and skeletal muscles (PubMed:11591708). Expression in spleen is up-regulated in response to anemia. Inactive as a transporter when expressed alone or co- expressed with SLC3A1 or SLC3A2 (PubMed:11943479, PubMed:11591708). Functional as a transporter when fused (via the C-terminus) with SLC3A1 or SLC3A2 (PubMed:11591708). Belongs to the amino acid-polyamine-organocation (APC) superfamily. amino acid transmembrane transport cytoplasm plasma membrane amino acid transport amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity membrane integral component of membrane transmembrane transporter activity transmembrane transport L-alpha-amino acid transmembrane transport uc008oqg.1 uc008oqg.2 uc008oqg.3 uc008oqg.4 
ENSMUST00000037324.12 Skp1 ENSMUST00000037324.12 S-phase kinase-associated protein 1 (from RefSeq NM_011543.4) ENSMUST00000037324.1 ENSMUST00000037324.10 ENSMUST00000037324.11 ENSMUST00000037324.2 ENSMUST00000037324.3 ENSMUST00000037324.4 ENSMUST00000037324.5 ENSMUST00000037324.6 ENSMUST00000037324.7 ENSMUST00000037324.8 ENSMUST00000037324.9 NM_011543 Q8C5H6 Q9WTX5 SKP1_MOUSE Skp1 Skp1a uc007ivf.1 uc007ivf.2 uc007ivf.3 uc007ivf.4 Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1- RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2 (By similarity). Protein modification; protein ubiquitination. Interacts with KDM2B, forming heterodimers (By similarity). The KDM2B-SKP1 heterodimeric complex interacts with the PCGF1-BCORL heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1) (By similarity). Component of multiple SCF (SKP1- CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate- specific subunit. Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXw2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7. Component of the SCF(FBXW15) complex containing FBXW15 (PubMed:23319590). Interacts with CEP68 (By similarity). Interacts with FBXW15 (PubMed:23319590). Interacts with NOTCH2 (By similarity). The SKP1-KDM2A and SKP1-KDM2B complexes interact with UBB (By similarity). Q9WTX5; Q9QXW2: Fbxw5; NbExp=2; IntAct=EBI-1202363, EBI-16031930; Q9WTX5; P62137: Ppp1ca; NbExp=2; IntAct=EBI-1202363, EBI-357187; Q9WTX5; Q9CQJ4: Rnf2; NbExp=4; IntAct=EBI-1202363, EBI-927321; Q9WTX5; Q9UKT7: FBXL3; Xeno; NbExp=4; IntAct=EBI-1202363, EBI-2557269; Undergoes autophagy-mediated degradation in the liver in a time- dependent manner. Belongs to the SKP1 family. ubiquitin-protein transferase activity protein binding nucleus nucleoplasm cytoplasm centrosome cytosol ubiquitin-dependent protein catabolic process beta-catenin binding protein ubiquitination SCF ubiquitin ligase complex protein domain specific binding SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Cul7-RING ubiquitin ligase complex PcG protein complex histone H2A monoubiquitination maintenance of protein location in nucleus ubiquitin protein ligase activity cullin family protein binding uc007ivf.1 uc007ivf.2 uc007ivf.3 uc007ivf.4 
ENSMUST00000037330.5 Inha ENSMUST00000037330.5 inhibin alpha, transcript variant 1 (from RefSeq NM_010564.6) ENSMUST00000037330.1 ENSMUST00000037330.2 ENSMUST00000037330.3 ENSMUST00000037330.4 INHA_MOUSE NM_010564 Q04997 Q6GTG7 uc007bps.1 uc007bps.2 uc007bps.3 This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mice in which this gene has been ablated exhibit sex cord-stromal tumors and symptoms that mimic the human cancer cachexia syndrome. [provided by RefSeq, Aug 2016]. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Inhibin deficient mice are viable but are acutely sensitive to development of gonadal sex-cord stromal tumors. Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Secreted. Proteolytic processing yields a number of bioactive forms, consisting either solely of the mature alpha chain, of the most N- terminal propeptide linked through a disulfide bond to the mature alpha chain, or of the entire proprotein. Belongs to the TGF-beta family. ovarian follicle development photoreceptor outer segment photoreceptor inner segment receptor binding cytokine activity transforming growth factor beta receptor binding hormone activity extracellular region extracellular space cytoplasm growth factor activity male gonad development positive regulation of pathway-restricted SMAD protein phosphorylation inhibin-betaglycan-ActRII complex inhibin binding regulation of cell proliferation hemoglobin biosynthetic process regulation of apoptotic process neuronal cell body regulation of MAPK cascade inhibin A complex inhibin B complex negative regulation of follicle-stimulating hormone secretion protein heterodimerization activity cell development regulation of cell cycle SMAD protein signal transduction uc007bps.1 uc007bps.2 uc007bps.3 
ENSMUST00000037337.10 Tbc1d19 ENSMUST00000037337.10 TBC1 domain family, member 19 (from RefSeq NM_144517.4) ENSMUST00000037337.1 ENSMUST00000037337.2 ENSMUST00000037337.3 ENSMUST00000037337.4 ENSMUST00000037337.5 ENSMUST00000037337.6 ENSMUST00000037337.7 ENSMUST00000037337.8 ENSMUST00000037337.9 NM_144517 Q8VDV7 Q8VDV7_MOUSE Tbc1d19 uc008xln.1 uc008xln.2 uc008xln.3 uc008xln.4 molecular_function cellular_component biological_process uc008xln.1 uc008xln.2 uc008xln.3 uc008xln.4 
ENSMUST00000037353.10 Eda2r ENSMUST00000037353.10 ectodysplasin A2 receptor, transcript variant 2 (from RefSeq NM_175540.6) ENSMUST00000037353.1 ENSMUST00000037353.2 ENSMUST00000037353.3 ENSMUST00000037353.4 ENSMUST00000037353.5 ENSMUST00000037353.6 ENSMUST00000037353.7 ENSMUST00000037353.8 ENSMUST00000037353.9 NM_175540 Q8BM50 Q8BX35 TNR27_MOUSE Tnfrsf27 Xedar uc009tus.1 uc009tus.2 uc009tus.3 uc009tus.4 Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6 (By similarity). Associates with TRAF1, TRAF3 and TRAF6. Membrane ; Single-pass type III membrane protein plasma membrane integral component of plasma membrane multicellular organism development programmed cell death membrane integral component of membrane cell differentiation signaling receptor activity positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade positive regulation of NF-kappaB transcription factor activity intrinsic apoptotic signaling pathway by p53 class mediator uc009tus.1 uc009tus.2 uc009tus.3 uc009tus.4 
ENSMUST00000037359.9 Klhl35 ENSMUST00000037359.9 kelch-like 35 (from RefSeq NM_028145.1) E9QMG1 ENSMUST00000037359.1 ENSMUST00000037359.2 ENSMUST00000037359.3 ENSMUST00000037359.4 ENSMUST00000037359.5 ENSMUST00000037359.6 ENSMUST00000037359.7 ENSMUST00000037359.8 KLH35_MOUSE NM_028145 Q9CZ49 uc009ilq.1 uc009ilq.2 uc009ilq.3 uc009ilq.4 uc009ilq.1 uc009ilq.2 uc009ilq.3 uc009ilq.4 
ENSMUST00000037360.8 Rhov ENSMUST00000037360.8 ras homolog family member V (from RefSeq NM_145530.2) ENSMUST00000037360.1 ENSMUST00000037360.2 ENSMUST00000037360.3 ENSMUST00000037360.4 ENSMUST00000037360.5 ENSMUST00000037360.6 ENSMUST00000037360.7 NM_145530 Q8VDU1 RHOV_MOUSE Rhov uc008ltm.1 uc008ltm.2 uc008ltm.3 uc008ltm.4 Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with PAK2. Cell membrane ; Lipid-anchor ; Cytoplasmic side Endosome membrane ; Lipid-anchor ; Cytoplasmic side Note=Treatment with TNFA activates endosomal but not plasma membrane RHOV. Belongs to the small GTPase superfamily. Rho family. nucleotide binding GTPase activity GTP binding cytoplasm endosome plasma membrane cell cortex endocytosis actin filament organization establishment or maintenance of cell polarity signal transduction small GTPase mediated signal transduction Rho protein signal transduction regulation of cell shape endosome membrane membrane protein kinase binding cell projection assembly actin cytoskeleton organization Cdc42 protein signal transduction regulation of actin cytoskeleton organization cell projection metal ion binding uc008ltm.1 uc008ltm.2 uc008ltm.3 uc008ltm.4 
ENSMUST00000037361.9 Lefty1 ENSMUST00000037361.9 left right determination factor 1 (from RefSeq NM_010094.4) ENSMUST00000037361.1 ENSMUST00000037361.2 ENSMUST00000037361.3 ENSMUST00000037361.4 ENSMUST00000037361.5 ENSMUST00000037361.6 ENSMUST00000037361.7 ENSMUST00000037361.8 Ebaf LFTY1_MOUSE Lefty NM_010094 Q3V2A9 Q64280 Stra3 Tgfb4 uc007dww.1 uc007dww.2 uc007dww.3 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. Mice lacking a functional copy of this gene exhibit embryonic lethality and defects in left-right patterning. [provided by RefSeq, Aug 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050221.1, AK131943.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Required for left-right axis determination as a regulator of LEFTY2 and NODAL. Secreted. By 8.0 dpc, expressed exclusively on the left side of developing embryos with expression predominantly in the prospective floor plate (PFP). Weak expression in the lateral-plate mesoderm (LPM). The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner. Belongs to the TGF-beta family. negative regulation of transcription from RNA polymerase II promoter heart morphogenesis cytokine activity transforming growth factor beta receptor binding extracellular region extracellular space multicellular organism development determination of left/right symmetry growth factor activity negative regulation of cell proliferation anterior/posterior axis specification positive regulation of pathway-restricted SMAD protein phosphorylation BMP signaling pathway response to retinoic acid nodal binding cell migration involved in gastrulation regulation of apoptotic process regulation of MAPK cascade cell development SMAD protein signal transduction negative regulation of nodal signaling pathway negative regulation of nodal receptor complex assembly uc007dww.1 uc007dww.2 uc007dww.3 
ENSMUST00000037370.14 Sorcs2 ENSMUST00000037370.14 sortilin-related VPS10 domain containing receptor 2 (from RefSeq NM_030889.2) B2RSI2 B2RSI4 ENSMUST00000037370.1 ENSMUST00000037370.10 ENSMUST00000037370.11 ENSMUST00000037370.12 ENSMUST00000037370.13 ENSMUST00000037370.2 ENSMUST00000037370.3 ENSMUST00000037370.4 ENSMUST00000037370.5 ENSMUST00000037370.6 ENSMUST00000037370.7 ENSMUST00000037370.8 ENSMUST00000037370.9 NM_030889 Q9EPR5 SORC2_MOUSE uc008xek.1 uc008xek.2 uc008xek.3 uc008xek.4 The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487, PubMed:27457814, PubMed:29909994). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (PubMed:29909994). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814, PubMed:29909994). Plays a role in BDNF-dependent hippocampal synaptic plasticity (PubMed:29909994, PubMed:27457814). Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (By similarity). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes (PubMed:28469074). Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (PubMed:30840898). Homodimer (in vitro) (PubMed:30061605). Heterodimer with NGFR (PubMed:22155786, PubMed:24908487, PubMed:27457814). The extracellular domains of the heterodimer bind the precursor form of NGF (proNGF) (PubMed:22155786). Can also bind mature NGF and BDNF. Each chain in the receptor dimer interacts (via extracellular domain) with an NGF dimer (in vitro) (PubMed:30061605). Interacts with the precursor forms of BDNF (proBDNF) and NTF3 (proNT3) (By similarity). The cytoplasmic region of the heterodimer formed by NGFR and SORCS2 binds TRIO. ProNGF binding mediates dissociation of TRIO from the receptor complex (By similarity). Interacts with SLC1A1 (PubMed:30840898). Interacts with VPS35. Interacts (via extracellular domain) with NTRK2 (via extracellular domain) (PubMed:27457814). Interacts with VPS35. Interacts (via extracellular domain) with GRIN2A (PubMed:28469074). Q9EPR5; Q9Z0W1: Ngfr; NbExp=4; IntAct=EBI-9915438, EBI-4411273; Cell membrane ingle-pass type I membrane protein Cell projection Cytoplasmic vesicle membrane ; Single-pass type I membrane protein Early endosome membrane Recycling endosome membrane Synapse, synaptosome Perikaryon Cell projection, dendrite Cell projection, dendritic spine Synapse Postsynaptic density membrane Detected in Purkinje cells and pyramidal neurons in brain cortex, cerebellum, dentate gyrus, striatum and hippocampus, and in glia cells in dorsal root ganglia (DRG) (PubMed:24908487, PubMed:27457814, PubMed:28469074, PubMed:30840898). Not detected in neurons from the dorsal root ganglia (PubMed:24908487). Detected in hair cells and supporting cells in the organ of Corti, utricuar maculae and cristae (at protein level) (PubMed:28346477). Detected in brain, lung and testis (PubMed:11165493). Detected in the inner ear in neonates (PubMed:28346477). Expression is highest in developing brain. Transiently expressed in all 3 germ layers (PubMed:11165493). Detected in midbrain, spinal cord, heart and lung at 15.5 dpc (PubMed:24908487). Coexpressed with NGFR in neurons in the ventral part of the hippocampus CA1 region at 23 and 30 days after birth. The number of neurons that coexpress SORCS2 and NGFR is increased 30 days after birth. SORCS2 and NGFR are no longer coexpressed in hippocampus neurons in 60 day old adults (PubMed:29909994). N-glycosylated. Proteolytic cleavage removes a propeptide, giving rise to a 122 kDa chain that includes a cytoplasmic tail. Further cleavage gives rise to a 104 kDa chain that lacks the cytoplasmic tail, and a membrane- bound 18 kDa chain (PubMed:24908487). The 104 kDa chain remains bound to the 18 kDa chain (By similarity). Mice are viable and fertile and display no obvious phenotype, but their neurons do not display growth cone collapse in response to proBDNF (PubMed:24908487, PubMed:29909994). Cultured neurons from mutant mice display longer neurites than wild- type neurons, and the frontal cortex of 12 week old mice is hyperinnervated with fibers from tyrosine hydroxylase-positive neurons (PubMed:24908487, PubMed:29909994). Mutant mice display mildly increased spontaneous locomotor activity; contrary to wild-type, treatment with amphetamine decreases their locomotor activity. After sciatic nerve injury, 2 day old and adult mice show discreased Schwann cell apoptosis distal to the lesion (PubMed:24908487). Mutant mice show increased mortality after seizures caused by repeated treatments with the convulsant pentylenetetrazol (PTZ). Hippocampus neurons from mutant mice display increased levels of oxidative stress and increased apoptosis (PubMed:30840898). Mutant mice display subtle behavorial defects, with hyperactivity, altered acquisition of spatial memory, but a normal startle response to noise (PubMed:27457814). Heterozygous mice have normal body weight and motor skills, but combination with a mouse model for Huntington disease (HD) gives rise to increased severity of impaired motor skills (PubMed:28469074). After a cross of mice carrying a Cre construct under the control of the Tek promoter with mice carrying a floxed Nppc gene a subset of the offspring displayed behavorial defects, including hyperactivity and hanging from cage tops. A subset (11 out of 33 mice) displayed strongly reduced body weight and profound deafness, with defects in the organization of the outer and inner hair cell bundles in the organ of Corti. Analysis of the genomic DNA from deaf mice showed that in 13 cases, these mice had the Cre construct inserted into the first intron of the Sorcs2 gene, but in 21 cases, the insertion had occured in an Ig kappa locus (PubMed:28346477). SORCS2 expression is decreased after the onset of symptoms in mouse models for Huntington disease (HD). SORCS2 does not interact with wild-type HTT, but does interact with mutant HTT containing a long polyglutamine stretch. Belongs to the VPS10-related sortilin family. SORCS subfamily. Gene disruption gives rise to contradictory results (PubMed:24908487, PubMed:27457814, PubMed:28469074, PubMed:28346477, PubMed:30840898). The majority of studies report normal body weight, normal startle responses to noise and relatively minor behavorial defects (PubMed:24908487, PubMed:27457814, PubMed:28469074, PubMed:30840898). Another publication finds that gene disruption gives rise to mice with strongly reduced body weight and profound deafness. Gene disruption was due to random insertion of a Cre construct under the control of the TEK promoter. Analysis of the genomic DNA showed that in 21 cases the Cre construct had inserted in an Ig kappa locus, and in 13 cases the construct had inserted into the first intron of the SORCS2 gene, leading to strongly reduced SORCS2 expression (PubMed:28346477). The reasons for these discrepancies are not clear, but may be due to the way the experiments were done. The fact that an identical phenotype was found when the Cre construct under the control of the TEK promoter had inserted in an Ig kappa locus suggests that there are additional, unidentified causes that play a role in the observed defects. protein binding endosome plasma membrane integral component of plasma membrane intracellular protein transport postsynaptic density membrane integral component of membrane cell junction dendrite cytoplasmic vesicle membrane cytoplasmic vesicle early endosome membrane cell projection neuron projection dendritic spine perikaryon synapse postsynaptic membrane recycling endosome membrane long term synaptic depression uc008xek.1 uc008xek.2 uc008xek.3 uc008xek.4 
ENSMUST00000037374.11 Gab3 ENSMUST00000037374.11 growth factor receptor bound protein 2-associated protein 3 (from RefSeq NM_181584.4) ENSMUST00000037374.1 ENSMUST00000037374.10 ENSMUST00000037374.2 ENSMUST00000037374.3 ENSMUST00000037374.4 ENSMUST00000037374.5 ENSMUST00000037374.6 ENSMUST00000037374.7 ENSMUST00000037374.8 ENSMUST00000037374.9 GAB3_MOUSE NM_181584 Q684I9 Q8BSM5 Q8VH53 uc009tpn.1 uc009tpn.2 uc009tpn.3 uc009tpn.4 Interacts with PIK3R/p85, SHP2 and GRAP2/MONA. May interact with Grb2. Highly expressed in spleen and thymus and weakly in brain, heart, lung, kidney, uterus, and embryonic stem cells. Also expressed in myeloid and macrophage cell lines. Phosphorylated on tyrosine residue(s) after macrophage colony- stimulating factor (M-CSF) receptor stimulation. Belongs to the GAB family. protein binding cellular_component macrophage differentiation uc009tpn.1 uc009tpn.2 uc009tpn.3 uc009tpn.4 
ENSMUST00000037375.10 Eps8l3 ENSMUST00000037375.10 EPS8-like 3 (from RefSeq NM_133867.2) ENSMUST00000037375.1 ENSMUST00000037375.2 ENSMUST00000037375.3 ENSMUST00000037375.4 ENSMUST00000037375.5 ENSMUST00000037375.6 ENSMUST00000037375.7 ENSMUST00000037375.8 ENSMUST00000037375.9 ES8L3_MOUSE Eps8r3 NM_133867 Q3TJ14 Q91WL0 uc008qxo.1 uc008qxo.2 uc008qxo.3 uc008qxo.4 Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Interacts with FASLG (By similarity). Cytoplasm Detected in embryonic gut. Detected in adult testis, placenta, adrenal gland and intestine. Belongs to the EPS8 family. actin binding cytoplasm plasma membrane Rho protein signal transduction ruffle membrane regulation of Rho protein signal transduction regulation of hair cycle positive regulation of ruffle assembly Rac guanyl-nucleotide exchange factor activity uc008qxo.1 uc008qxo.2 uc008qxo.3 uc008qxo.4 
ENSMUST00000037376.14 Nagk ENSMUST00000037376.14 N-acetylglucosamine kinase, transcript variant 18 (from RefSeq NR_177204.1) ENSMUST00000037376.1 ENSMUST00000037376.10 ENSMUST00000037376.11 ENSMUST00000037376.12 ENSMUST00000037376.13 ENSMUST00000037376.2 ENSMUST00000037376.3 ENSMUST00000037376.4 ENSMUST00000037376.5 ENSMUST00000037376.6 ENSMUST00000037376.7 ENSMUST00000037376.8 ENSMUST00000037376.9 Gnk NAGK_MOUSE NR_177204 Q9QZ08 uc009coh.1 uc009coh.2 uc009coh.3 uc009coh.4 Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:10824116). Also has N-acetylmannosamine (ManNAc) kinase activity (PubMed:10824116). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (PubMed:22692205). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575). Reaction=ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D- glucosamine 6-phosphate; Xref=Rhea:RHEA:17417, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57513, ChEBI:CHEBI:456216, ChEBI:CHEBI:506227; EC=2.7.1.59; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17418; Evidence=; Reaction=ATP + N-acetyl-D-mannosamine = ADP + H(+) + N-acetyl-D- mannosamine 6-phosphate; Xref=Rhea:RHEA:25253, ChEBI:CHEBI:15378, ChEBI:CHEBI:17122, ChEBI:CHEBI:30616, ChEBI:CHEBI:58557, ChEBI:CHEBI:456216; EC=2.7.1.60; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25254; Evidence=; Reaction=ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine = 6-O- phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+); Xref=Rhea:RHEA:75935, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:155830, ChEBI:CHEBI:194492, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75936; Evidence=; Amino-sugar metabolism; N-acetylneuraminate degradation. Homodimer. Ubiquitous. No visible phenotype in absence of infection (PubMed:36002575). Macrophages are completely deficient in muramyl dipeptide (MDP) sensing (PubMed:36002575). Belongs to the eukaryotic-type N-acetylglucosamine kinase family. nucleotide binding ATP binding N-acetylglucosamine metabolic process N-acylmannosamine kinase activity kinase activity phosphorylation transferase activity N-acetylneuraminate catabolic process N-acetylglucosamine kinase activity carbohydrate phosphorylation uc009coh.1 uc009coh.2 uc009coh.3 uc009coh.4 
ENSMUST00000037378.6 1700020L24Rik ENSMUST00000037378.6 RIKEN cDNA 1700020L24 gene (from RefSeq NM_025492.3) A7MCU3 CQ050_MOUSE ENSMUST00000037378.1 ENSMUST00000037378.2 ENSMUST00000037378.3 ENSMUST00000037378.4 ENSMUST00000037378.5 NM_025492 Q8C1R3 Q9DAI8 uc007koz.1 uc007koz.2 uc007koz.3 uc007koz.4 molecular_function cellular_component biological_process uc007koz.1 uc007koz.2 uc007koz.3 uc007koz.4 
ENSMUST00000037383.13 Ldah ENSMUST00000037383.13 lipid droplet associated hydrolase, transcript variant 6 (from RefSeq NR_157106.1) A0A0F6AIX5 A0A0F6AIX5_MOUSE ENSMUST00000037383.1 ENSMUST00000037383.10 ENSMUST00000037383.11 ENSMUST00000037383.12 ENSMUST00000037383.2 ENSMUST00000037383.3 ENSMUST00000037383.4 ENSMUST00000037383.5 ENSMUST00000037383.6 ENSMUST00000037383.7 ENSMUST00000037383.8 ENSMUST00000037383.9 Ldah NR_157106 uc007mzh.1 uc007mzh.2 uc007mzh.3 Lipid droplet Belongs to the AB hydrolase superfamily. LDAH family. uc007mzh.1 uc007mzh.2 uc007mzh.3 
ENSMUST00000037397.8 Cep126 ENSMUST00000037397.8 centrosomal protein 126, transcript variant 2 (from RefSeq NM_001368148.1) CE126_MOUSE Cep126 ENSMUST00000037397.1 ENSMUST00000037397.2 ENSMUST00000037397.3 ENSMUST00000037397.4 ENSMUST00000037397.5 ENSMUST00000037397.6 ENSMUST00000037397.7 Kiaa1377 NM_001368148 Q0VBV7 Q6ZPS8 uc009odj.1 uc009odj.2 uc009odj.3 Participate in cytokinesis (By similarity). Necessary for microtubules and mitotic spindle organization (By similarity). Involved in primary cilium formation (By similarity). Interacts with DCTN1 (By similarity). Midbody Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton mitotic spindle organization midbody cytoplasmic microtubule organization cell projection cilium assembly ciliary base non-motile cilium assembly uc009odj.1 uc009odj.2 uc009odj.3 
ENSMUST00000037399.16 Blvrb ENSMUST00000037399.16 biliverdin reductase B, transcript variant 1 (from RefSeq NM_144923.3) BLVRB_MOUSE ENSMUST00000037399.1 ENSMUST00000037399.10 ENSMUST00000037399.11 ENSMUST00000037399.12 ENSMUST00000037399.13 ENSMUST00000037399.14 ENSMUST00000037399.15 ENSMUST00000037399.2 ENSMUST00000037399.3 ENSMUST00000037399.4 ENSMUST00000037399.5 ENSMUST00000037399.6 ENSMUST00000037399.7 ENSMUST00000037399.8 ENSMUST00000037399.9 NM_144923 Q923D2 uc009fwd.1 uc009fwd.2 uc009fwd.3 Broad specificity oxidoreductase that catalyzes the NADPH- dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. Reaction=NADP(+) + reduced riboflavin = 2 H(+) + NADPH + riboflavin; Xref=Rhea:RHEA:19377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17607, ChEBI:CHEBI:57783, ChEBI:CHEBI:57986, ChEBI:CHEBI:58349; EC=1.5.1.30; Evidence=; Reaction=bilirubin IXalpha + NAD(+) = biliverdin IXalpha + H(+) + NADH; Xref=Rhea:RHEA:15797, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57977, ChEBI:CHEBI:57991; EC=1.3.1.24; Evidence=; Reaction=bilirubin IXalpha + NADP(+) = biliverdin IXalpha + H(+) + NADPH; Xref=Rhea:RHEA:15793, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57977, ChEBI:CHEBI:57991, ChEBI:CHEBI:58349; EC=1.3.1.24; Evidence=; Monomer. Cytoplasm biliverdin reductase activity nucleoplasm cytoplasm cytosol plasma membrane oxidoreductase activity heme catabolic process riboflavin reductase (NADPH) activity terminal bouton oxidation-reduction process uc009fwd.1 uc009fwd.2 uc009fwd.3 
ENSMUST00000037401.10 Phf20 ENSMUST00000037401.10 PHD finger protein 20 (from RefSeq NM_172674.2) ENSMUST00000037401.1 ENSMUST00000037401.2 ENSMUST00000037401.3 ENSMUST00000037401.4 ENSMUST00000037401.5 ENSMUST00000037401.6 ENSMUST00000037401.7 ENSMUST00000037401.8 ENSMUST00000037401.9 Hca58 NM_172674 PHF20_MOUSE Q8BLG0 Q8BMA2 Q8BYR4 Q921N1 uc008nmy.1 uc008nmy.2 uc008nmy.3 Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage (By similarity). Methyllysine- binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Homodimer; disulfide-linked. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BLG0-1; Sequence=Displayed; Name=2; IsoId=Q8BLG0-2; Sequence=VSP_007762; The Tudor domain 2 mediates reading of dimethyl-lysine residues. The Tudor domain 1 doesn't bind dimethyl-lysine residues, due to an atypical and occluded aromatic cage. Ubiquitinated by TRIM26; leading to proteasomal degradation. Mice die shortly after birth and display a wide variety of phenotypes within the skeletal and hematopoietic systems. [Isoform 2]: Incomplete sequence. histone acetyltransferase complex nucleic acid binding DNA binding nucleus nucleoplasm cytosol chromatin organization regulation of transcription, DNA-templated nuclear membrane histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) metal ion binding histone acetyltransferase activity (H4-K16 specific) MLL1 complex uc008nmy.1 uc008nmy.2 uc008nmy.3 
ENSMUST00000037418.7 Tmed8 ENSMUST00000037418.7 transmembrane p24 trafficking protein 8 (from RefSeq NM_001033475.3) ENSMUST00000037418.1 ENSMUST00000037418.2 ENSMUST00000037418.3 ENSMUST00000037418.4 ENSMUST00000037418.5 ENSMUST00000037418.6 NM_001033475 Q3UHI4 TMED8_MOUSE uc007oin.1 uc007oin.2 uc007oin.3 molecular_function cellular_component biological_process uc007oin.1 uc007oin.2 uc007oin.3 
ENSMUST00000037419.4 Pramel1 ENSMUST00000037419.4 PRAME like 1 (from RefSeq NM_031377.2) ENSMUST00000037419.1 ENSMUST00000037419.2 ENSMUST00000037419.3 NM_031377 PRAL1_MOUSE Pramel1 Q99MW3 uc008vqc.1 uc008vqc.2 uc008vqc.3 uc008vqc.4 May play a role in acrosome development and also in sperm maturation and motility. Cytoplasm Cytoplasmic vesicle, secretory vesicle, acrosome Cell projection, cilium, flagellum Note=Located in the cytoplasm of spermatocytes and in the acrosomal vesicle region of round, elongating and elongated spermatids. Detected in the main piece of the flagellum in testicular spermatozoa. Detected also in the connecting piece, middle piece and cytoplasmic droplets of epididymal spermatozoa. Specifically expressed in testis (at protein level). Expressed in the spermatogenic cells during early spermatogenesis (at protein level). Expressed postnatally from week 1 onwards with a slight increase in expression levels until week 3 (at protein level). Belongs to the PRAME family. acrosomal vesicle molecular_function cytoplasm cilium biological_process positive regulation of cell proliferation cytoplasmic vesicle motile cilium cell projection negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vqc.1 uc008vqc.2 uc008vqc.3 uc008vqc.4 
ENSMUST00000037422.16 Rnf44 ENSMUST00000037422.16 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UHJ8-1; Sequence=Displayed; Name=2; IsoId=Q3UHJ8-2; Sequence=VSP_022550, VSP_022551; Name=3; IsoId=Q3UHJ8-3; Sequence=VSP_022550; (from UniProt Q3UHJ8) BC035548 ENSMUST00000037422.1 ENSMUST00000037422.10 ENSMUST00000037422.11 ENSMUST00000037422.12 ENSMUST00000037422.13 ENSMUST00000037422.14 ENSMUST00000037422.15 ENSMUST00000037422.2 ENSMUST00000037422.3 ENSMUST00000037422.4 ENSMUST00000037422.5 ENSMUST00000037422.6 ENSMUST00000037422.7 ENSMUST00000037422.8 ENSMUST00000037422.9 Kiaa1100 Q3TAC8 Q3TVH9 Q3UHJ8 Q6ZPX8 Q8VD22 RNF44_MOUSE uc007qox.1 uc007qox.2 uc007qox.3 uc007qox.4 uc007qox.5 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UHJ8-1; Sequence=Displayed; Name=2; IsoId=Q3UHJ8-2; Sequence=VSP_022550, VSP_022551; Name=3; IsoId=Q3UHJ8-3; Sequence=VSP_022550; Sequence=AAH17630.1; Type=Erroneous initiation; Evidence=; Sequence=AAH35548.1; Type=Erroneous initiation; Evidence=; Sequence=BAC98100.1; Type=Frameshift; Evidence=; metal ion binding uc007qox.1 uc007qox.2 uc007qox.3 uc007qox.4 uc007qox.5 
ENSMUST00000037423.4 Ovol2 ENSMUST00000037423.4 ovo like zinc finger 2, transcript variant A (from RefSeq NM_026924.3) ENSMUST00000037423.1 ENSMUST00000037423.2 ENSMUST00000037423.3 NM_026924 OVOL2_MOUSE Ovo2 Ovol2 Q505Q7 Q6F661 Q8CIV6 Q8CIV7 Q8K0D6 Q9D949 Zfp339 Znf339 uc008mqx.1 uc008mqx.2 uc008mqx.3 uc008mqx.4 Zinc-finger transcription repressor factor (PubMed:15225875, PubMed:23319585, PubMed:36228616). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (PubMed:24735878, PubMed:24735879). Positively regulates neuronal differentiation (PubMed:16423343, PubMed:23319585). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (By similarity). Important for the correct development of primordial germ cells in embryos (PubMed:28059165). Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (PubMed:36228616). Interacts (via zinc-finger domains) with CEBPA (via bZIP domain); the interaction inhibits the transcription factor activity of CEBPA and is required to repress adipogenesis. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=MOVO-A; IsoId=Q8CIV7-1; Sequence=Displayed; Name=2; Synonyms=MOVO-C; IsoId=Q8CIV7-2; Sequence=VSP_013577, VSP_013578; Name=3; Synonyms=MOVO-B; IsoId=Q8CIV7-3; Sequence=VSP_013576; Expressed highly in testis, specifically in spermatocytes. Expressed also in skin and at lower levels in the ovary (PubMed:12213202, PubMed:15225875, PubMed:9468311, PubMed:36228616). Expressed in adipose tissues. Expression is lower than in testis and a relatively higher expression level is detected in the stromal vascular fraction (SVF) than in fat cells themselves (PubMed:36228616). Expressed during early-mid embryogenesis, particularly in the inner cell mass at 3.5 dpc, in epiblast at 6.5 dpc, and at later stages in ectodermally derived tissues such as the rostral surface ectoderm (PubMed:16423343). Expressed in embryonic stem cells, epiblasts of 6.4 dpc embryos and primordial germ cells (PGCs) (PubMed:28059165). High expression levels in PGCs of 8.5 dpc embryos decrease over embryogenesis (PubMed:28059165). Up-regulated during prepupertal testis development (PubMed:15225875). Down-regulated during embryonic stem cell neural differentiation and up-regulated by BMP4. Mutant embryos are small and die at 9.5 dpc-10.5 dpc with an open neural tube, impaired extra-embryonic and embryonic vascularization, abnormal cardiogenesis and placental defects (PubMed:16423343). Reduced number of primordial germ cells in 8.0 dpc embryos (PubMed:28059165). [Isoform 3]: Major form in the testis. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis neural crest cell migration neural fold formation heart looping nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus multicellular organism development heart development negative regulation of cell proliferation epidermis development epidermal cell differentiation dorsal/ventral pattern formation positive regulation of gene expression negative regulation of gene expression negative regulation of epithelial to mesenchymal transition regulation of keratinocyte proliferation negative regulation of transcription by competitive promoter binding sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of keratinocyte differentiation positive regulation of keratinocyte differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding embryonic digestive tract morphogenesis regulation of cell cycle endocardium formation heart trabecula formation regulation of SMAD protein import into nucleus labyrinthine layer blood vessel development cellular response to transforming growth factor beta stimulus negative regulation of stem cell proliferation uc008mqx.1 uc008mqx.2 uc008mqx.3 uc008mqx.4 
ENSMUST00000037434.13 Cacna2d4 ENSMUST00000037434.13 Membrane ; Single- pass type I membrane protein (from UniProt F8VPL1) BC141091 Cacna2d4 ENSMUST00000037434.1 ENSMUST00000037434.10 ENSMUST00000037434.11 ENSMUST00000037434.12 ENSMUST00000037434.2 ENSMUST00000037434.3 ENSMUST00000037434.4 ENSMUST00000037434.5 ENSMUST00000037434.6 ENSMUST00000037434.7 ENSMUST00000037434.8 ENSMUST00000037434.9 F8VPL1 F8VPL1_MOUSE uc009dlz.1 uc009dlz.2 Membrane ; Single- pass type I membrane protein Belongs to the calcium channel subunit alpha-2/delta family. voltage-gated calcium channel activity voltage-gated calcium channel complex detection of light stimulus involved in visual perception calcium ion transmembrane transport uc009dlz.1 uc009dlz.2 
ENSMUST00000037453.5 Prss34 ENSMUST00000037453.5 serine protease 34 (from RefSeq NM_178372.2) ENSMUST00000037453.1 ENSMUST00000037453.2 ENSMUST00000037453.3 ENSMUST00000037453.4 Mcp11 NM_178372 Prss34 Q80UR4 Q80UR4_MOUSE uc008bam.1 uc008bam.2 uc008bam.3 uc008bam.4 serine-type endopeptidase activity glycosaminoglycan binding extracellular space proteolysis heparin binding peptidase activity serine-type peptidase activity peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan extracellular matrix uc008bam.1 uc008bam.2 uc008bam.3 uc008bam.4 
ENSMUST00000037473.6 Ap5m1 ENSMUST00000037473.6 adaptor-related protein complex 5, mu 1 subunit, transcript variant 1 (from RefSeq NM_144535.5) A0A0R4J0K9 A0A0R4J0K9_MOUSE Ap5m1 ENSMUST00000037473.1 ENSMUST00000037473.2 ENSMUST00000037473.3 ENSMUST00000037473.4 ENSMUST00000037473.5 NM_144535 uc007tjz.1 uc007tjz.2 uc007tjz.3 uc007tjz.4 Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the adaptor complexes medium subunit family. lysosome late endosome cytosol protein transport membrane endosomal transport AP-type membrane coat adaptor complex uc007tjz.1 uc007tjz.2 uc007tjz.3 uc007tjz.4 
ENSMUST00000037478.13 Slc18a1 ENSMUST00000037478.13 solute carrier family 18 (vesicular monoamine), member 1 (from RefSeq NM_153054.2) ENSMUST00000037478.1 ENSMUST00000037478.10 ENSMUST00000037478.11 ENSMUST00000037478.12 ENSMUST00000037478.2 ENSMUST00000037478.3 ENSMUST00000037478.4 ENSMUST00000037478.5 ENSMUST00000037478.6 ENSMUST00000037478.7 ENSMUST00000037478.8 ENSMUST00000037478.9 NM_153054 Q8R090 VMAT1_MOUSE Vmat1 uc009lwt.1 uc009lwt.2 uc009lwt.3 Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin (PubMed:21712771). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli (By similarity). Reaction=2 H(+)(out) + serotonin(in) = 2 H(+)(in) + serotonin(out); Xref=Rhea:RHEA:73743, ChEBI:CHEBI:15378, ChEBI:CHEBI:350546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73744; Evidence=; Reaction=(R)-noradrenaline(in) + 2 H(+)(out) = (R)-noradrenaline(out) + 2 H(+)(in); Xref=Rhea:RHEA:73747, ChEBI:CHEBI:15378, ChEBI:CHEBI:72587; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73748; Evidence=; Reaction=dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in); Xref=Rhea:RHEA:73739, ChEBI:CHEBI:15378, ChEBI:CHEBI:59905; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73740; Evidence=; Inhibited by reserpine, and the proton ionophore carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP). Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Detected in adrenal medulla, and brain (at protein level). In brain, specifically found in the medulla oblongata, pons, prefrontal cortex, striatum, dentate gyrus and hippocampus (at protein level). Increased apoptosis and reduced neurogenesis in the hippocampus. Spatial memory formation is mildly impaired. Belongs to the major facilitator superfamily. Vesicular transporter family. serotonin:sodium symporter activity cytoplasm integral component of plasma membrane neurotransmitter transport monoamine transmembrane transporter activity aminergic neurotransmitter loading into synaptic vesicle membrane integral component of membrane enzyme binding cell junction cytoplasmic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle positive regulation of dopamine secretion xenobiotic transport xenobiotic transporter activity terminal bouton synapse serotonin uptake negative regulation of serotonin uptake transmembrane transport uc009lwt.1 uc009lwt.2 uc009lwt.3 
ENSMUST00000037480.9 Wipf2 ENSMUST00000037480.9 WAS/WASL interacting protein family, member 2 (from RefSeq NM_197940.2) ENSMUST00000037480.1 ENSMUST00000037480.2 ENSMUST00000037480.3 ENSMUST00000037480.4 ENSMUST00000037480.5 ENSMUST00000037480.6 ENSMUST00000037480.7 ENSMUST00000037480.8 NM_197940 Q6PEV3 WIPF2_MOUSE Wire uc007lht.1 uc007lht.2 uc007lht.3 uc007lht.4 Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system (By similarity). Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions (By similarity). Cytoplasm, cytoskeleton Note=Localized to stress fibers and bundles of actin filaments. Belongs to the verprolin family. actin cortical patch assembly actin binding nucleoplasm cytoplasm cytoskeleton actin filament plasma membrane endocytosis actin filament-based movement actin cortical patch actin filament binding actin cortical patch localization uc007lht.1 uc007lht.2 uc007lht.3 uc007lht.4 
ENSMUST00000037481.10 Clec1a ENSMUST00000037481.10 C-type lectin domain family 1, member a, transcript variant 1 (from RefSeq NM_175526.3) CLC1A_MOUSE ENSMUST00000037481.1 ENSMUST00000037481.2 ENSMUST00000037481.3 ENSMUST00000037481.4 ENSMUST00000037481.5 ENSMUST00000037481.6 ENSMUST00000037481.7 ENSMUST00000037481.8 ENSMUST00000037481.9 NM_175526 Q7TPX7 Q8BMH5 Q8BWY2 uc009eft.1 uc009eft.2 uc009eft.3 uc009eft.4 Membrane ; Single-pass type II membrane protein cellular_component biological_process membrane integral component of membrane carbohydrate binding uc009eft.1 uc009eft.2 uc009eft.3 uc009eft.4 
ENSMUST00000037488.8 Dock4 ENSMUST00000037488.8 dedicator of cytokinesis 4 (from RefSeq NM_172803.2) B2RUG6 DOCK4_MOUSE ENSMUST00000037488.1 ENSMUST00000037488.2 ENSMUST00000037488.3 ENSMUST00000037488.4 ENSMUST00000037488.5 ENSMUST00000037488.6 ENSMUST00000037488.7 Kiaa0716 NM_172803 P59764 uc007nlh.1 uc007nlh.2 uc007nlh.3 uc007nlh.4 Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form. Involved in regulation of adherens junction between cells. Plays a role in cell migration. [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. Interacts with nucleotide-free Rap1; functions as a guanine nucleotide exchange factor (GEF) for Rap1. Interacts (via DOCKER domain) with RAC1; functions as a guanine nucleotide exchange factor (GEF) for RAC1. Interacts with the SH3 domain of CRK. Interacts with FASLG. Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2. Interacts with USH1C (via PDZ 1 domain). Cell membrane Cytoplasm, cytosol Note=Colocalizes with EPHA2, RHOG and CTTN/cortactin at the tip of protrusions in migrating cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P59764-1; Sequence=Displayed; Name=2; IsoId=P59764-2; Sequence=VSP_060556, VSP_060557; [Isoform 2]: Expressed in inner ear (at protein level). [Isoform 2]: Expressed in the utricular hair bundles at 14.5 dpc (at protein level) (PubMed:16464467). At P1 expressed in cochlear hair bundles of the sensory cells extending to the apical surface of the greater epithelial ridge and in the vestibule where it is restricted to hair bundles (at protein level) (PubMed:16464467). The DOCKER domain mediates interaction with small GTPases like RAC1 and is required for their activation. Belongs to the DOCK family. guanyl-nucleotide exchange factor activity GTPase activator activity nucleolus cytoplasm Golgi apparatus cytosol plasma membrane small GTPase mediated signal transduction membrane SH3 domain binding PDZ domain binding receptor tyrosine kinase binding stereocilium stereocilium bundle positive regulation of GTPase activity Rac GTPase binding cell chemotaxis negative regulation of vascular smooth muscle contraction positive regulation of vascular associated smooth muscle cell migration uc007nlh.1 uc007nlh.2 uc007nlh.3 uc007nlh.4 
ENSMUST00000037489.15 Agpat1 ENSMUST00000037489.15 1-acylglycerol-3-phosphate O-acyltransferase 1, transcript variant 9 (from RefSeq NM_001414242.1) A0A0R4J263 A0A0R4J263_MOUSE Agpat1 ENSMUST00000037489.1 ENSMUST00000037489.10 ENSMUST00000037489.11 ENSMUST00000037489.12 ENSMUST00000037489.13 ENSMUST00000037489.14 ENSMUST00000037489.2 ENSMUST00000037489.3 ENSMUST00000037489.4 ENSMUST00000037489.5 ENSMUST00000037489.6 ENSMUST00000037489.7 ENSMUST00000037489.8 ENSMUST00000037489.9 NM_001414242 uc008ccz.1 uc008ccz.2 uc008ccz.3 Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Reaction=(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3- phosphate + CoA; Xref=Rhea:RHEA:37603, ChEBI:CHEBI:57287, ChEBI:CHEBI:74544, ChEBI:CHEBI:75121, ChEBI:CHEBI:75122; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37604; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn- glycero-3-phosphate = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)- octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37179, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74581, ChEBI:CHEBI:74582; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37180; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn- glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)- octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37139, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74549, ChEBI:CHEBI:74550; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37140; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74544, ChEBI:CHEBI:74546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37132; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37183, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74583, ChEBI:CHEBI:74584; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37184; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:33187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57518, ChEBI:CHEBI:64839; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33188; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3- phosphate = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3- phosphate + CoA; Xref=Rhea:RHEA:37187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72683, ChEBI:CHEBI:74586; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37188; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero- 3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn- glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37159, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74544, ChEBI:CHEBI:74563; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37160; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37155, ChEBI:CHEBI:57287, ChEBI:CHEBI:74307, ChEBI:CHEBI:74544, ChEBI:CHEBI:74558; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37156; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37143, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74544, ChEBI:CHEBI:74551; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37144; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37175, ChEBI:CHEBI:57287, ChEBI:CHEBI:74309, ChEBI:CHEBI:74544, ChEBI:CHEBI:74578; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37176; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37171, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:74544, ChEBI:CHEBI:74579; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37172; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19710; Evidence=; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 2/3. The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. positive regulation of cytokine production 1-acylglycerol-3-phosphate O-acyltransferase activity endoplasmic reticulum lipid metabolic process phosphatidic acid biosynthetic process phospholipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups uc008ccz.1 uc008ccz.2 uc008ccz.3 
ENSMUST00000037499.6 Immp1l ENSMUST00000037499.6 IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) (from RefSeq NM_028260.3) ENSMUST00000037499.1 ENSMUST00000037499.2 ENSMUST00000037499.3 ENSMUST00000037499.4 ENSMUST00000037499.5 IMP1L_MOUSE NM_028260 Q3THN4 Q9CQU8 uc008lle.1 uc008lle.2 Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity). Heterodimer of 2 subunits, IMMPL1 and IMMPL2. Mitochondrion inner membrane Belongs to the peptidase S26 family. IMP1 subfamily. mitochondrion mitochondrial inner membrane proteolysis protein processing involved in protein targeting to mitochondrion peptidase activity serine-type peptidase activity membrane hydrolase activity mitochondrial inner membrane peptidase complex uc008lle.1 uc008lle.2 
ENSMUST00000037502.7 Fam117a ENSMUST00000037502.7 family with sequence similarity 117, member A (from RefSeq NM_172543.4) ENSMUST00000037502.1 ENSMUST00000037502.2 ENSMUST00000037502.3 ENSMUST00000037502.4 ENSMUST00000037502.5 ENSMUST00000037502.6 F117A_MOUSE NM_172543 Q3TJJ0 Q3TND5 Q7TNF9 Q8BJY9 uc007lag.1 uc007lag.2 uc007lag.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TNF9-1; Sequence=Displayed; Name=2; IsoId=Q7TNF9-2; Sequence=VSP_021901; Belongs to the FAM117 family. molecular_function biological_process uc007lag.1 uc007lag.2 uc007lag.3 
ENSMUST00000037526.11 Tanc1 ENSMUST00000037526.11 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1, transcript variant 1 (from RefSeq NM_198294.3) A2AUL4 A2AUL6 ENSMUST00000037526.1 ENSMUST00000037526.10 ENSMUST00000037526.2 ENSMUST00000037526.3 ENSMUST00000037526.4 ENSMUST00000037526.5 ENSMUST00000037526.6 ENSMUST00000037526.7 ENSMUST00000037526.8 ENSMUST00000037526.9 NM_198294 Q0VGY8 Q80VD2 Q8C0Q6 TANC1_MOUSE uc008jtj.1 uc008jtj.2 uc008jtj.3 uc008jtj.4 May be a scaffold component in the postsynaptic density. Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1. Interacts with TNIK and MINK1 (By similarity). Postsynaptic density Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0VGY8-1; Sequence=Displayed; Name=2; IsoId=Q0VGY8-2; Sequence=VSP_030829, VSP_030830, VSP_030831; Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A. Belongs to the TANC family. Sequence=CAM27490.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM27492.1; Type=Erroneous gene model prediction; Evidence=; molecular_function plasma membrane myoblast fusion visual learning postsynaptic density membrane cell junction dendrite neuronal cell body axon terminus synapse postsynaptic membrane dendritic spine maintenance glutamatergic synapse postsynaptic density, intracellular component uc008jtj.1 uc008jtj.2 uc008jtj.3 uc008jtj.4 
ENSMUST00000037528.10 Gdpd5 ENSMUST00000037528.10 glycerophosphodiester phosphodiesterase domain containing 5, transcript variant 1 (from RefSeq NM_201352.3) ENSMUST00000037528.1 ENSMUST00000037528.2 ENSMUST00000037528.3 ENSMUST00000037528.4 ENSMUST00000037528.5 ENSMUST00000037528.6 ENSMUST00000037528.7 ENSMUST00000037528.8 ENSMUST00000037528.9 GDPD5_MOUSE Gde2 Gdpd5 NM_201352 Q640M6 Q8R0T5 Q8R3N5 uc009ilo.1 uc009ilo.2 uc009ilo.3 Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (PubMed:17275818, PubMed:18667693). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (PubMed:18667693). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; Reaction=H2O + sn-glycerol 3-phosphocholine = choline + H(+) + sn- glycerol 3-phosphate; Xref=Rhea:RHEA:16061, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:57597; EC=3.1.4.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16062; Evidence=; Inhibited by high level of NaCl or urea. Interacts with PRDX1; forms a mixed-disulfide with PRDX1, leading to disrupt intramolecular disulfide bond between Cys-25 and Cys-571. Endomembrane system ulti-pass membrane protein Cytoplasm, perinuclear region ll projection, growth cone Detected in brain, lung, heart, kidney and testis. Up-regulated during neuronal differentiation by retinoic acid. Down regulated by high NaCl or urea (PubMed:18667693). Intramolecular disulfide bond between Cys-25 and Cys-571 is reduced by PRDX1. Belongs to the glycerophosphoryl diester phosphodiesterase family. Sequence=AAH26428.1; Type=Erroneous initiation; Evidence=; phosphatidylinositol phospholipase C activity cytoplasm endoplasmic reticulum membrane lipid metabolic process nervous system development phosphoric diester hydrolase activity glycerophosphodiester phosphodiesterase activity endomembrane system membrane integral component of membrane hydrolase activity spinal cord motor neuron differentiation cerebral cortex neuron differentiation axon growth cone neuron projection development cell projection neuronal cell body positive regulation of neuron differentiation negative regulation of Notch signaling pathway positive regulation of cell cycle glycerophosphocholine phosphodiesterase activity perinuclear region of cytoplasm regulation of timing of cell differentiation perinuclear endoplasmic reticulum uc009ilo.1 uc009ilo.2 uc009ilo.3 
ENSMUST00000037534.8 Rnf167 ENSMUST00000037534.8 ring finger protein 167, transcript variant 1 (from RefSeq NM_027445.3) ENSMUST00000037534.1 ENSMUST00000037534.2 ENSMUST00000037534.3 ENSMUST00000037534.4 ENSMUST00000037534.5 ENSMUST00000037534.6 ENSMUST00000037534.7 NM_027445 Q3U4S5 Q91XF4 RN167_MOUSE uc007jvt.1 uc007jvt.2 uc007jvt.3 uc007jvt.4 E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway. Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'- polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1. Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'- linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex. Also involved in protein trafficking and localization. Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2. Does not catalyze ubiquitination of GluA1/GRIA1. Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3. Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B. Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18. Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Lysosome membrane ; Single-pass type I membrane protein Endosome membrane ; Single-pass type I membrane protein Endomembrane system ; Single-pass membrane protein Cell membrane ; Single-pass type I membrane protein Note=Targeted to cytoplasmic membranes; mainly localizes to lysosomal membrane. A subpopulation localizes to the cell membrane of neurons. Autoubiquitinated in vitro in the presence of UBE2D1 and UBE2E1. Belongs to the Godzilla family. protein polyubiquitination ubiquitin-protein transferase activity cytoplasm ubiquitin-dependent protein catabolic process zinc ion binding endomembrane system membrane integral component of membrane protein ubiquitination transferase activity negative regulation of cell cycle metal ion binding ubiquitin protein ligase activity uc007jvt.1 uc007jvt.2 uc007jvt.3 uc007jvt.4 
ENSMUST00000037539.15 Eva1c ENSMUST00000037539.15 eva-1 homolog C, transcript variant 1 (from RefSeq NM_001199210.2) A2RSZ2 ENSMUST00000037539.1 ENSMUST00000037539.10 ENSMUST00000037539.11 ENSMUST00000037539.12 ENSMUST00000037539.13 ENSMUST00000037539.14 ENSMUST00000037539.2 ENSMUST00000037539.3 ENSMUST00000037539.4 ENSMUST00000037539.5 ENSMUST00000037539.6 ENSMUST00000037539.7 ENSMUST00000037539.8 ENSMUST00000037539.9 EVA1C_MOUSE Fam176c NM_001199210 P58659 Q497W3 Q9D4L3 uc007zwr.1 uc007zwr.2 uc007zwr.3 uc007zwr.4 uc007zwr.5 Binds heparin. Cell membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P58659-1; Sequence=Displayed; Name=2; IsoId=P58659-2; Sequence=VSP_026601; Name=3; IsoId=P58659-3; Sequence=VSP_026600; Ubiquitous. Belongs to the EVA1 family. extracellular region plasma membrane biological_process heparin binding membrane integral component of membrane carbohydrate binding uc007zwr.1 uc007zwr.2 uc007zwr.3 uc007zwr.4 uc007zwr.5 
ENSMUST00000037540.5 P2ry2 ENSMUST00000037540.5 purinergic receptor P2Y, G-protein coupled 2, transcript variant 1 (from RefSeq NM_008773.4) A0A0R4J289 A0A0R4J289_MOUSE ENSMUST00000037540.1 ENSMUST00000037540.2 ENSMUST00000037540.3 ENSMUST00000037540.4 NM_008773 P2ry2 uc009inz.1 uc009inz.2 uc009inz.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway membrane integral component of membrane G-protein coupled purinergic nucleotide receptor signaling pathway G-protein coupled purinergic nucleotide receptor activity positive regulation of mucus secretion regulation of blood vessel diameter uc009inz.1 uc009inz.2 uc009inz.3 
ENSMUST00000037541.9 Dgat2l6 ENSMUST00000037541.9 diacylglycerol O-acyltransferase 2-like 6 (from RefSeq NM_001114084.1) A2ADU8 DG2L6_MOUSE ENSMUST00000037541.1 ENSMUST00000037541.2 ENSMUST00000037541.3 ENSMUST00000037541.4 ENSMUST00000037541.5 ENSMUST00000037541.6 ENSMUST00000037541.7 ENSMUST00000037541.8 NM_001114084 uc012hmt.1 uc012hmt.2 uc012hmt.3 Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters. Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219, ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the diacylglycerol acyltransferase family. cellular_component endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process biological_process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups uc012hmt.1 uc012hmt.2 uc012hmt.3 
ENSMUST00000037547.9 Disp2 ENSMUST00000037547.9 dispatched RND transporter family member 2 (from RefSeq NM_170593.3) DISP2_MOUSE ENSMUST00000037547.1 ENSMUST00000037547.2 ENSMUST00000037547.3 ENSMUST00000037547.4 ENSMUST00000037547.5 ENSMUST00000037547.6 ENSMUST00000037547.7 ENSMUST00000037547.8 Kiaa1742 NM_170593 Q148A2 Q80T98 Q8CBA3 Q8CIP5 uc008lsr.1 uc008lsr.2 uc008lsr.3 uc008lsr.4 The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AY150699.1, SRR1660817.163056.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849379, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CIP5-1; Sequence=Displayed; Name=2; IsoId=Q8CIP5-2; Sequence=VSP_029324, VSP_029325; Belongs to the dispatched family. molecular_function cellular_component plasma membrane biological_process membrane integral component of membrane uc008lsr.1 uc008lsr.2 uc008lsr.3 uc008lsr.4 
ENSMUST00000037551.15 Ppp1r16a ENSMUST00000037551.15 protein phosphatase 1, regulatory subunit 16A, transcript variant 2 (from RefSeq NM_033371.3) ENSMUST00000037551.1 ENSMUST00000037551.10 ENSMUST00000037551.11 ENSMUST00000037551.12 ENSMUST00000037551.13 ENSMUST00000037551.14 ENSMUST00000037551.2 ENSMUST00000037551.3 ENSMUST00000037551.4 ENSMUST00000037551.5 ENSMUST00000037551.6 ENSMUST00000037551.7 ENSMUST00000037551.8 ENSMUST00000037551.9 Mypt3 NM_033371 PP16A_MOUSE Q4V9Z1 Q923M0 uc007wlo.1 uc007wlo.2 uc007wlo.3 Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. Binds PP1. Cell membrane ; Lipid-anchor Highly expressed in testis, followed by liver, heart, brain and lung. cytosol plasma membrane biological_process membrane protein phosphatase regulator activity regulation of phosphoprotein phosphatase activity uc007wlo.1 uc007wlo.2 uc007wlo.3 
ENSMUST00000037552.10 Lepr ENSMUST00000037552.10 leptin receptor, transcript variant 1 (from RefSeq NM_146146.3) Db ENSMUST00000037552.1 ENSMUST00000037552.2 ENSMUST00000037552.3 ENSMUST00000037552.4 ENSMUST00000037552.5 ENSMUST00000037552.6 ENSMUST00000037552.7 ENSMUST00000037552.8 ENSMUST00000037552.9 LEPR_MOUSE NM_146146 O35686 O54986 Obr P48356 Q61215 Q64309 Q9QWG3 Q9QWV5 uc008tvz.1 uc008tvz.2 uc008tvz.3 uc008tvz.4 Receptor for hormone LEP/leptin (Probable) (PubMed:11861497). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS (PubMed:10799542, PubMed:25383904, PubMed:11923481, PubMed:11861497). In the hypothalamus, LEP acts as an appetite- regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:10660043, PubMed:12594516). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25383904, PubMed:11923481). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis (PubMed:12594516). Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus (PubMed:25383904). Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (PubMed:9732873). [Isoform A]: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis (PubMed:17620316, PubMed:20223942). Does not induce phosphorylation of and activate STAT3 (PubMed:11923481, PubMed:20223942). [Isoform E]: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis. Present as a mixture of monomers and dimers (Probable). The phosphorylated receptor binds a number of SH2 domain-containing proteins such as JAK2, STAT3, PTPN11, and SOCS3 (By similarity) (PubMed:11018044, PubMed:11923481). Interaction with SOCS3 inhibits JAK/STAT signaling and MAPK cascade (PubMed:11018044). P48356; Q62120: Jak2; NbExp=3; IntAct=EBI-2257257, EBI-646604; P48356; P41160: Lep; NbExp=6; IntAct=EBI-2257257, EBI-16108810; P48356; Q91ZX7: Lrp1; NbExp=2; IntAct=EBI-2257257, EBI-300955; P48356; Q62077: Plcg1; NbExp=2; IntAct=EBI-2257257, EBI-300133; P48356-1; Q8NFJ9: BBS1; Xeno; NbExp=3; IntAct=EBI-6143588, EBI-1805484; Cell membrane ; Single-pass type I membrane protein Basolateral cell membrane [Isoform E]: Secreted Event=Alternative splicing; Named isoforms=5; Name=B; IsoId=P48356-1; Sequence=Displayed; Name=A; IsoId=P48356-2; Sequence=VSP_001697, VSP_001698; Name=C; IsoId=P48356-3; Sequence=VSP_001699, VSP_001700; Name=D; IsoId=P48356-4; Sequence=VSP_001701, VSP_001702; Name=E; IsoId=P48356-5; Sequence=VSP_001703, VSP_001704; Isoform A: highest level of expression in lung and kidney, also present in heart, brain, spleen, liver, muscle, choroid plexus and hypothalamus. Isoform B: highest levels of expression in hypothalamus and lower levels in brain, testes and adipose tissue. Expressed by neurons of the parabrachial nucleus (PubMed:25383904). Expressed by peripheral blood mononuclear cells and CD4(+) T-cells (PubMed:9732873). Isoform E: expressed in adipose tissue, liver, hypothalamus, cerebral microvessels, heart, and testes (PubMed:17620316). The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-985 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1138 is required for STAT3 binding/activation. Phosphorylation of Tyr-1077 has a more accessory role. Mutants are hyperphagic, obese, infertile, diabetic and have impaired growth (PubMed:12594516). Have wet brain weight significantly lower than controls. Brain uptake of leptin is also reduced (PubMed:11861497). Animals have an increased bone formation leading to high bone mass (PubMed:10660043). Have impaired T- cell immunity, Th2 responses are favoured in mutants (PubMed:9732873). Conditional knockout in parabrachial nucleus CCK-expressing neurons, treated with 2-deoxyglucose, have increased levels of glucagon, corticosterone and epinephrin concentrations compared to wild-types (PubMed:25383904). Belongs to the type I cytokine receptor family. Type 2 subfamily. angiogenesis transmembrane signaling receptor activity cytokine receptor activity protein binding extracellular region extracellular space plasma membrane integral component of plasma membrane glycogen metabolic process phagocytosis signal transduction cholesterol metabolic process external side of plasma membrane negative regulation of autophagy glial cell proliferation membrane integral component of membrane basolateral plasma membrane protein-hormone receptor activity peptide hormone binding regulation of metabolic process sexual reproduction cytokine binding T cell differentiation leptin-mediated signaling pathway positive regulation of insulin secretion involved in cellular response to glucose stimulus leptin receptor activity glucose homeostasis eating behavior identical protein binding receptor complex positive regulation of MAPK cascade response to leptin negative regulation of gluconeogenesis regulation of bone remodeling negative regulation of hydrolase activity regulation of feeding behavior energy homeostasis bone growth negative regulation of eating behavior negative regulation of locomotor rhythm uc008tvz.1 uc008tvz.2 uc008tvz.3 uc008tvz.4 
ENSMUST00000037553.6 Galp ENSMUST00000037553.6 galanin-like peptide (from RefSeq NM_178028.2) A5GXX4 ENSMUST00000037553.1 ENSMUST00000037553.2 ENSMUST00000037553.3 ENSMUST00000037553.4 ENSMUST00000037553.5 GALP_MOUSE NM_178028 Q810H5 uc009fax.1 uc009fax.2 [Isoform 1]: Hypothalamic neuropeptide which binds to the G- protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion. [Isoform 2]: Exhibits antimicrobial activity against Gram- negative bacterias, inducing bacterial membrane blebbing (By similarity). Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q810H5-1; Sequence=Displayed; Name=2; Synonyms=Alarin; IsoId=Q810H5-2; Sequence=VSP_030462; Isoform 2 is found in brain, thymus and skin. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells. [Isoform 2]: Cleavage of the signal peptide generates a peptide of 25 amino acids, termed alarin because of the N-terminal alanine and the C-terminal serine. Vasoactive peptide. Belongs to the galanin family. receptor binding hormone activity cellular_component extracellular region neuropeptide signaling pathway response to hormone regulation of appetite response to insulin modification of morphology or physiology of other organism behavioral response to starvation defense response to bacterium defense response to Gram-negative bacterium uc009fax.1 uc009fax.2 
ENSMUST00000037557.9 Mon2 ENSMUST00000037557.9 MON2 homolog, regulator of endosome to Golgi trafficking, transcript variant 3 (from RefSeq NM_153395.2) ENSMUST00000037557.1 ENSMUST00000037557.2 ENSMUST00000037557.3 ENSMUST00000037557.4 ENSMUST00000037557.5 ENSMUST00000037557.6 ENSMUST00000037557.7 ENSMUST00000037557.8 Kiaa1040 MON2_MOUSE NM_153395 Q3TRE3 Q80TL7 Q8BTA8 Q8K4V3 Sf21 uc007hgk.1 uc007hgk.2 uc007hgk.3 uc007hgk.4 Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer- mediated endosomal sorting of WLS away from lysosomal degradation. Homooligomer. Heterotrimer with ATP9A and DOP1B; this interaction is retromer-independent. Interacts with SNX3. Early endosome membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80TL7-1; Sequence=Displayed; Name=2; IsoId=Q80TL7-2; Sequence=VSP_027394, VSP_027395; Belongs to the MON2 family. Sequence=BAC25345.1; Type=Frameshift; Evidence=; Sequence=BAC65707.1; Type=Erroneous initiation; Evidence=; cytosol Golgi to endosome transport protein transport uc007hgk.1 uc007hgk.2 uc007hgk.3 uc007hgk.4 
ENSMUST00000037585.9 Dennd6a ENSMUST00000037585.9 DENN domain containing 6A, transcript variant 1 (from RefSeq NM_001134465.2) DEN6A_MOUSE ENSMUST00000037585.1 ENSMUST00000037585.2 ENSMUST00000037585.3 ENSMUST00000037585.4 ENSMUST00000037585.5 ENSMUST00000037585.6 ENSMUST00000037585.7 ENSMUST00000037585.8 NM_001134465 Q3UX21 Q6KAP4 Q8BH65 Q8BSG0 Q8C4Z7 Q8K2E8 Q8R136 uc007ssy.1 uc007ssy.2 uc007ssy.3 uc007ssy.4 uc007ssy.5 Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes (By similarity). Recycling endosome Cytoplasm Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BH65-1; Sequence=Displayed; Name=2; IsoId=Q8BH65-2; Sequence=VSP_025920, VSP_025921; Name=3; IsoId=Q8BH65-3; Sequence=VSP_025918; Name=4; IsoId=Q8BH65-4; Sequence=VSP_025918, VSP_025919; Belongs to the DENND6 family. Identified as having similarity to the core DENN family and referred to as DENN6A. Prediction methods do not indicate a DENN domain for this sequence and, the exact role of the DENN or the DENN-like domain in GEF activity needs to be clarified. Sequence=BAD21413.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; guanyl-nucleotide exchange factor activity cytoplasm endosome Rab guanyl-nucleotide exchange factor activity intracellular membrane-bounded organelle recycling endosome positive regulation of cell-cell adhesion mediated by cadherin uc007ssy.1 uc007ssy.2 uc007ssy.3 uc007ssy.4 uc007ssy.5 
ENSMUST00000037593.14 Ankrd13b ENSMUST00000037593.14 ankyrin repeat domain 13b, transcript variant 2 (from RefSeq NM_001373883.1) AN13B_MOUSE B9EKW8 ENSMUST00000037593.1 ENSMUST00000037593.10 ENSMUST00000037593.11 ENSMUST00000037593.12 ENSMUST00000037593.13 ENSMUST00000037593.2 ENSMUST00000037593.3 ENSMUST00000037593.4 ENSMUST00000037593.5 ENSMUST00000037593.6 ENSMUST00000037593.7 ENSMUST00000037593.8 ENSMUST00000037593.9 NM_001373883 Q5F259 Q6IR40 uc011xzw.1 uc011xzw.2 uc011xzw.3 Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). Interacts with EGFR (ubiquitinated); the interaction is direct and may regulate EGFR internalization. Cell membrane. Late endosome. Early endosome. Note=Interaction with EGFR may enhance association with the cell membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5F259-1; Sequence=Displayed; Name=2; IsoId=Q5F259-2; Sequence=VSP_019405; negative regulation of receptor internalization cytoplasm endosome early endosome late endosome plasma membrane membrane intracellular membrane-bounded organelle perinuclear region of cytoplasm uc011xzw.1 uc011xzw.2 uc011xzw.3 
ENSMUST00000037607.11 Map3k7 ENSMUST00000037607.11 mitogen-activated protein kinase kinase kinase 7, transcript variant B (from RefSeq NM_009316.1) ENSMUST00000037607.1 ENSMUST00000037607.10 ENSMUST00000037607.2 ENSMUST00000037607.3 ENSMUST00000037607.4 ENSMUST00000037607.5 ENSMUST00000037607.6 ENSMUST00000037607.7 ENSMUST00000037607.8 ENSMUST00000037607.9 Map3k7 NM_009316 Q923A8 Q923A8_MOUSE uc008seq.1 uc008seq.2 uc008seq.3 uc008seq.4 uc008seq.5 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation. Cytoplasm Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. nucleotide binding activation of MAPKK activity activation of MAPK activity magnesium ion binding positive regulation of T cell cytokine production protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity ATP binding Ada2/Gcn5/Ada3 transcription activator complex cytoplasm plasma membrane protein phosphorylation apoptotic process signal transduction activation of NF-kappaB-inducing kinase activity I-kappaB phosphorylation JNK cascade IkappaB kinase complex membrane kinase activity phosphorylation transferase activity receptor tyrosine kinase binding positive regulation of interleukin-2 production identical protein binding positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JUN kinase activity histone H3 acetylation metal ion binding stress-activated MAPK cascade scaffold protein binding uc008seq.1 uc008seq.2 uc008seq.3 uc008seq.4 uc008seq.5 
ENSMUST00000037609.8 Hgsnat ENSMUST00000037609.8 heparan-alpha-glucosaminide N-acetyltransferase (from RefSeq NM_029884.2) D8Ertd354e E9QNP9 ENSMUST00000037609.1 ENSMUST00000037609.2 ENSMUST00000037609.3 ENSMUST00000037609.4 ENSMUST00000037609.5 ENSMUST00000037609.6 ENSMUST00000037609.7 HGNAT_MOUSE NM_029884 Q3TWK5 Q3UDW8 Q8CBU7 Q8CIE1 Tmem76 uc009lhg.1 uc009lhg.2 uc009lhg.3 Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. Reaction=acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) = CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n); Xref=Rhea:RHEA:15125, Rhea:RHEA-COMP:9830, Rhea:RHEA-COMP:11585, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58388, ChEBI:CHEBI:70974; EC=2.3.1.78; Evidence=; Homooligomer. Homooligomerization is necessary for enzyme activity (By similarity). Lysosome membrane ; Multi-pass membrane protein Note=Colocalizes with the lysosomal marker LAMP2. The signal peptide is not cleaved upon translocation into the endoplasmic reticulum; the precursor is probably targeted to the lysosomes via the adapter protein complex-mediated pathway that involves tyrosine- and/or dileucine-based conserved amino acid motifs in the last C-terminus 16-amino acid domain (By similarity). Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=Q3UDW8-1; Sequence=Displayed; Name=2; IsoId=Q3UDW8-2; Sequence=VSP_040505; Expressed in the retina. Expressed in the developing eye as early as 14 dpc, with equal high expression levels after birth (postnatal day 1 (P1) and postnatal day 30 (P30)). Undergoes intralysosomal proteolytic cleavage; occurs within the end of the first and/or the beginning of the second luminal domain and is essential for the activation of the enzyme. Glycosylated. A signal sequence is predicted but has been shown not to be cleaved in the reticulum endoplasmic. Sequence=AAH24084.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC29006.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE31601.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE35261.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE35603.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; lysosome lysosomal membrane lysosomal transport heparan-alpha-glucosaminide N-acetyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring acyl groups protein oligomerization uc009lhg.1 uc009lhg.2 uc009lhg.3 
ENSMUST00000037615.7 Aldh5a1 ENSMUST00000037615.7 aldhehyde dehydrogenase family 5, subfamily A1 (from RefSeq NM_172532.3) ENSMUST00000037615.1 ENSMUST00000037615.2 ENSMUST00000037615.3 ENSMUST00000037615.4 ENSMUST00000037615.5 ENSMUST00000037615.6 NM_172532 Q5SZW1 Q8BWF0 SSDH_MOUSE uc007pwp.1 uc007pwp.2 uc007pwp.3 Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Reaction=H2O + NAD(+) + succinate semialdehyde = 2 H(+) + NADH + succinate; Xref=Rhea:RHEA:13217, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30031, ChEBI:CHEBI:57540, ChEBI:CHEBI:57706, ChEBI:CHEBI:57945; EC=1.2.1.24; Redox-regulated. Inhibited under oxydizing conditions (By similarity). Amino-acid degradation; 4-aminobutanoate degradation. Homotetramer. Mitochondrion Belongs to the aldehyde dehydrogenase family. succinate-semialdehyde dehydrogenase (NAD+) activity mitochondrion succinate metabolic process glutamate metabolic process central nervous system development succinate-semialdehyde dehydrogenase [NAD(P)+] activity gamma-aminobutyric acid metabolic process gamma-aminobutyric acid catabolic process post-embryonic development oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor carboxylic acid binding neurotransmitter catabolic process NAD binding protein homotetramerization oxidation-reduction process uc007pwp.1 uc007pwp.2 uc007pwp.3 
ENSMUST00000037620.14 Mospd3 ENSMUST00000037620.14 motile sperm domain containing 3, transcript variant 1 (from RefSeq NM_030037.2) ENSMUST00000037620.1 ENSMUST00000037620.10 ENSMUST00000037620.11 ENSMUST00000037620.12 ENSMUST00000037620.13 ENSMUST00000037620.2 ENSMUST00000037620.3 ENSMUST00000037620.4 ENSMUST00000037620.5 ENSMUST00000037620.6 ENSMUST00000037620.7 ENSMUST00000037620.8 ENSMUST00000037620.9 MSPD3_MOUSE NM_030037 Q8BGG6 uc009ada.1 uc009ada.2 uc009ada.3 uc009ada.4 uc009ada.5 Membrane ; Multi-pass membrane protein Detected in heart, kidney, liver, spleen and brain. Note=Defects in Mospd3 are a cause of defects of the right heart ventricle and of high mortality in newborns. endoplasmic reticulum membrane plasma membrane heart development membrane integral component of membrane FFAT motif binding endoplasmic reticulum-plasma membrane tethering endoplasmic reticulum membrane organization uc009ada.1 uc009ada.2 uc009ada.3 uc009ada.4 uc009ada.5 
ENSMUST00000037623.15 Nrn1 ENSMUST00000037623.15 neuritin 1, transcript variant 1 (from RefSeq NM_153529.2) Cpg15 ENSMUST00000037623.1 ENSMUST00000037623.10 ENSMUST00000037623.11 ENSMUST00000037623.12 ENSMUST00000037623.13 ENSMUST00000037623.14 ENSMUST00000037623.2 ENSMUST00000037623.3 ENSMUST00000037623.4 ENSMUST00000037623.5 ENSMUST00000037623.6 ENSMUST00000037623.7 ENSMUST00000037623.8 ENSMUST00000037623.9 NM_153529 NRN1_MOUSE Q7TSR9 Q8CFV4 uc007qcm.1 uc007qcm.2 uc007qcm.3 uc007qcm.4 uc007qcm.5 Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Cell membrane ; Lipid-anchor, GPI- anchor Synapse Expressed in the brain (at protein level). By synaptic activity through NMDA receptors and L-type voltage-sensitive calcium channels. By cAMP in active neurons. Belongs to the neuritin family. extracellular space plasma membrane nervous system development axonogenesis membrane cell junction anchored component of membrane AMPA glutamate receptor complex protein homodimerization activity synapse anchored component of plasma membrane protein heterodimerization activity glutamatergic synapse neuron projection extension regulation of synaptic vesicle exocytosis uc007qcm.1 uc007qcm.2 uc007qcm.3 uc007qcm.4 uc007qcm.5 
ENSMUST00000037633.16 Zc3h7a ENSMUST00000037633.16 zinc finger CCCH type containing 7 A, transcript variant 2 (from RefSeq NR_027502.1) E9PWW6 E9PWW6_MOUSE ENSMUST00000037633.1 ENSMUST00000037633.10 ENSMUST00000037633.11 ENSMUST00000037633.12 ENSMUST00000037633.13 ENSMUST00000037633.14 ENSMUST00000037633.15 ENSMUST00000037633.2 ENSMUST00000037633.3 ENSMUST00000037633.4 ENSMUST00000037633.5 ENSMUST00000037633.6 ENSMUST00000037633.7 ENSMUST00000037633.8 ENSMUST00000037633.9 NR_027502 Zc3h7a uc033gxp.1 uc033gxp.2 uc033gxp.3 nucleic acid binding cellular_component posttranscriptional regulation of gene expression production of miRNAs involved in gene silencing by miRNA miRNA binding metal ion binding uc033gxp.1 uc033gxp.2 uc033gxp.3 
ENSMUST00000037636.4 Ina ENSMUST00000037636.4 internexin neuronal intermediate filament protein, alpha (from RefSeq NM_146100.5) AINX_MOUSE ENSMUST00000037636.1 ENSMUST00000037636.2 ENSMUST00000037636.3 NM_146100 P46660 Q61958 Q8VCW5 uc008huk.1 uc008huk.2 uc008huk.3 uc008huk.4 Class-IV neuronal intermediate filament that is able to self- assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges (By similarity). May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (PubMed:22723690). Forms homodimers (in vitro) (By similarity). Forms heterodimers with NEFL, NEFM or NEFH (in vitro) (By similarity). O-glycosylated. Belongs to the intermediate filament family. protein binding nucleoplasm intermediate filament neurofilament multicellular organism development nervous system development cell differentiation nuclear membrane cytoplasmic ribonucleoprotein granule myelin sheath intermediate filament cytoskeleton organization intermediate filament cytoskeleton protein heterodimerization activity neurofilament cytoskeleton organization postsynapse structural constituent of postsynaptic actin cytoskeleton postsynaptic actin cytoskeleton organization glutamatergic synapse cellular response to leukemia inhibitory factor uc008huk.1 uc008huk.2 uc008huk.3 uc008huk.4 
ENSMUST00000037646.9 Prdm4 ENSMUST00000037646.9 PR domain containing 4, transcript variant 2 (from RefSeq NM_001302886.1) A0A1X7SB67 A0A1X7SB67_MOUSE ENSMUST00000037646.1 ENSMUST00000037646.2 ENSMUST00000037646.3 ENSMUST00000037646.4 ENSMUST00000037646.5 ENSMUST00000037646.6 ENSMUST00000037646.7 ENSMUST00000037646.8 NM_001302886 Prdm4 uc007gnf.1 uc007gnf.2 uc007gnf.3 uc007gnf.4 uc007gnf.5 This gene encodes a member of the PR/SET family of zinc finger proteins. This protein has been shown to bind DNA in a sequence-specific manner and has been implicated in neural stem cell proliferation and differentiation. Pseudogenes have been identified on chromosomes 14 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]. May function as a transcription factor involved in cell differentiation. Nucleus nucleic acid binding DNA binding nucleus transcription from RNA polymerase II promoter histone methyltransferase binding uc007gnf.1 uc007gnf.2 uc007gnf.3 uc007gnf.4 uc007gnf.5 
ENSMUST00000037649.6 Rab3gap1 ENSMUST00000037649.6 RAB3 GTPase activating protein subunit 1, transcript variant 2 (from RefSeq NM_178690.5) ENSMUST00000037649.1 ENSMUST00000037649.2 ENSMUST00000037649.3 ENSMUST00000037649.4 ENSMUST00000037649.5 Kiaa0066 NM_178690 Q3TPB6 Q6A0D7 Q80UJ7 Q8C4Y0 Q8C679 Q8C6A5 Q8K324 RB3GP_MOUSE Rab3gap uc007clc.1 uc007clc.2 uc007clc.3 uc007clc.4 Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of Rab3gap1 and Rab3gap2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (By similarity). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (By similarity). Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (By similarity). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). The Rab3 GTPase-activating complex is a heterodimer composed of Rab3gap1 and Rab3gap2 (By similarity). The Rab3 GTPase-activating complex interacts with DMXL2 (By similarity). Interacts with LMAN1 (By similarity). Cytoplasm Endoplasmic reticulum Note=In neurons, it is enriched in the synaptic soluble fraction. In the eye, it is highly expressed within the lens, particularly in the anterior lens epithelium and in a ring corresponding to the equatorial region where anterior cells are differentiating into lens fibers. Also highly expressed in the retina. From 10 dpc to 12 dpc, it is weakly expressed throughout the embryo. At 14.5 dpc, it is predominantly expressed in a number of organ systems, including the central and peripheral nervous systems. Belongs to the Rab3-GAP catalytic subunit family. Sequence=BAD32159.1; Type=Erroneous initiation; Evidence=; GTPase activator activity cytoplasm Golgi apparatus lipid particle brain development positive regulation of gene expression regulation of synaptic vesicle priming Rab guanyl-nucleotide exchange factor activity Rab GTPase binding hypothalamus development regulation of Rab protein signal transduction macromolecular complex lipid particle organization camera-type eye development regulation of GTPase activity positive regulation of GTPase activity regulation of short-term neuronal synaptic plasticity synaptic vesicle transport protein stabilization excitatory postsynaptic potential face morphogenesis positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization endoplasmic reticulum tubular network establishment of protein localization to endoplasmic reticulum membrane postsynapse positive regulation of protein lipidation regulation of calcium ion-dependent exocytosis of neurotransmitter positive regulation of endoplasmic reticulum tubular network organization positive regulation of autophagosome assembly uc007clc.1 uc007clc.2 uc007clc.3 uc007clc.4 
ENSMUST00000037666.6 Mfhas1 ENSMUST00000037666.6 malignant fibrous histiocytoma amplified sequence 1, transcript variant 3 (from RefSeq NR_157105.1) ENSMUST00000037666.1 ENSMUST00000037666.2 ENSMUST00000037666.3 ENSMUST00000037666.4 ENSMUST00000037666.5 MFHA1_MOUSE Mfhas1 NR_157105 Q3TAN2 Q3V1N1 Q8C4N5 uc009lla.1 uc009lla.2 Probable GTP-binding protein (By similarity). Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways (PubMed:20616063, PubMed:26599367). Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor (By similarity). Both inhibits and activates the TLR2-dependent signaling pathway (PubMed:26599367). Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro- inflammatory M1 phenotype. It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway. Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway (By similarity). Interacts with RAF1. Interacts with HSPD1. Interacts with PPP2CA; retains PPP2CA into the cytoplasm and excludes it from the nucleus. Interacts with PPP2R2A; the interaction is direct. Interacts with PJA2. Cytoplasm Up-regulated by lipopolysaccharides (LPS) (at protein level). Ubiquitinated. Ubiquitination by PJA2 does not lead MFHAS1 to proteasomal degradation but positively regulates its function in polarization of macrophages. nucleotide binding immune system process GTP binding cytoplasm defense response inflammatory response negative regulation of signal transduction erythrocyte differentiation ubiquitin protein ligase binding regulation of toll-like receptor signaling pathway negative regulation of toll-like receptor 2 signaling pathway positive regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 4 signaling pathway negative regulation of protein dephosphorylation regulation of macrophage activation innate immune response positive regulation of JNK cascade negative regulation of inflammatory response protein phosphatase 2A binding positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade negative regulation of protein localization to nucleus positive regulation of p38MAPK cascade uc009lla.1 uc009lla.2 
ENSMUST00000037682.3 Nmur2 ENSMUST00000037682.3 neuromedin U receptor 2 (from RefSeq NM_153079.4) ENSMUST00000037682.1 ENSMUST00000037682.2 NMUR2_MOUSE NM_153079 Q8BZ39 Q91Z76 uc007izq.1 uc007izq.2 uc007izq.3 Receptor for the neuromedin-U and neuromedin-S neuropeptides. Cell membrane; Multi-pass membrane protein. Expressed primarily in brain tissues, more specifically in medulla and spinal cord. Widespread distribution in peripheral tissues. Belongs to the G-protein coupled receptor 1 family. neuromedin U receptor activity reduction of food intake in response to dietary excess G-protein coupled receptor activity intracellular calcium activated chloride channel activity GTP binding plasma membrane calcium ion transport signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway central nervous system development grooming behavior neuropeptide receptor activity membrane integral component of membrane ion transmembrane transport neuromedin U binding activation of phospholipase A2 activity by calcium-mediated signaling inositol phosphate-mediated signaling response to pain arachidonic acid secretion regulation of sensory perception of pain uc007izq.1 uc007izq.2 uc007izq.3 
ENSMUST00000037685.9 Mucl2 ENSMUST00000037685.9 mucin-like 2 (from RefSeq NM_009267.2) ENSMUST00000037685.1 ENSMUST00000037685.2 ENSMUST00000037685.3 ENSMUST00000037685.4 ENSMUST00000037685.5 ENSMUST00000037685.6 ENSMUST00000037685.7 ENSMUST00000037685.8 MUCL2_MOUSE Mucl2 NM_009267 P02815 Q3KQK8 Q62263 Q9DA65 Spt-1 Spt1 uc029svn.1 uc029svn.2 uc029svn.3 Secreted, extracellular space Expressed in submandibular gland and lacrimal gland. Not detected in other tissues. molecular_function cellular_component extracellular region extracellular space biological_process uc029svn.1 uc029svn.2 uc029svn.3 
ENSMUST00000037687.8 Tmem35a ENSMUST00000037687.8 transmembrane protein 35A (from RefSeq NM_026239.2) ENSMUST00000037687.1 ENSMUST00000037687.2 ENSMUST00000037687.3 ENSMUST00000037687.4 ENSMUST00000037687.5 ENSMUST00000037687.6 ENSMUST00000037687.7 NACHO_MOUSE NM_026239 Nacho Q9D328 Q9DB64 Tmem35 Tmem35a uc009uft.1 uc009uft.2 Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622, PubMed:28445721, PubMed:32204458). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3- beta-2 and alpha-3-beta-4 receptors (PubMed:26875622, PubMed:28445721, PubMed:32204458). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (PubMed:32783947). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:28445721). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (By similarity). May interact with NGFR (By similarity). Interacts with RPN1, RPN2 and CANX (PubMed:32783947). Peroxisome membrane ; Multi-pass membrane protein Cytoplasmic vesicle Endoplasmic reticulum membrane ; Multi- pass membrane protein Note=Shedding may lead to a soluble peptide. Brain (at protein level) (PubMed:27170659, PubMed:26875622, PubMed:28445721). Expressed in the spinal cord dorsal horn (at protein level) (PubMed:33422618). Mice show a complete disruption of the assembly and function of the neuronal acetylcholine receptor (nAChR) subunit alpha-7 (CHRNA7) in the brain (PubMed:26875622, PubMed:32204458). Exhibit enhanced locomotor activity, profound abnormalities in spatial/working memory and a significant reduction of assembled nAChRs in the brain (PubMed:28445721). Display thermal hyperalgesia and mechanical allodynia accompanied by an increased number of microglia in the spinal cord dorsal horn (PubMed:33422618). Exhibit elevated basal serum corticosterone accompanied by increased anxiety-like behavior and an impairment of long-term memory (PubMed:27170659). Belongs to the DoxX family. molecular_function cellular_component peroxisome peroxisomal membrane biological_process membrane integral component of membrane cytoplasmic vesicle uc009uft.1 uc009uft.2 
ENSMUST00000037696.6 Aoc1l3 ENSMUST00000037696.6 amine oxidase copper containing 1-like 3 (from RefSeq NM_172888.3) Aoc1l3 ENSMUST00000037696.1 ENSMUST00000037696.2 ENSMUST00000037696.3 ENSMUST00000037696.4 ENSMUST00000037696.5 NM_172888 Q6WIZ7 Q6WIZ7_MOUSE Svs1 uc009bwe.1 uc009bwe.2 uc009bwe.3 uc009bwe.4 uc009bwe.5 Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Note=Contains 1 topaquinone per subunit. ; Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. Belongs to the copper/topaquinone oxidase family. copper ion binding plasma membrane primary amine oxidase activity amine metabolic process oxidoreductase activity response to antibiotic metal ion binding quinone binding diamine oxidase activity oxidation-reduction process uc009bwe.1 uc009bwe.2 uc009bwe.3 uc009bwe.4 uc009bwe.5 
ENSMUST00000037708.10 Asic4 ENSMUST00000037708.10 acid-sensing ion channel family member 4 (from RefSeq NM_183022.3) ASIC4_MOUSE Accn4 ENSMUST00000037708.1 ENSMUST00000037708.2 ENSMUST00000037708.3 ENSMUST00000037708.4 ENSMUST00000037708.5 ENSMUST00000037708.6 ENSMUST00000037708.7 ENSMUST00000037708.8 ENSMUST00000037708.9 NM_183022 Q7TNS7 Q80XK4 uc007bpg.1 uc007bpg.2 uc007bpg.3 Probable cation channel with high affinity for sodium. Homotrimer or heterotrimer with other ASIC proteins. Membrane ; Multi-pass membrane protein In vitro, has no proton-gated channel activity. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily. behavioral fear response sodium channel activity ion transport sodium ion transport membrane integral component of membrane sodium ion transmembrane transport uc007bpg.1 uc007bpg.2 uc007bpg.3 
ENSMUST00000037709.16 Tm7sf3 ENSMUST00000037709.16 transmembrane 7 superfamily member 3 (from RefSeq NM_026281.2) A0A0R4J0K4 A0A0R4J0K4_MOUSE ENSMUST00000037709.1 ENSMUST00000037709.10 ENSMUST00000037709.11 ENSMUST00000037709.12 ENSMUST00000037709.13 ENSMUST00000037709.14 ENSMUST00000037709.15 ENSMUST00000037709.2 ENSMUST00000037709.3 ENSMUST00000037709.4 ENSMUST00000037709.5 ENSMUST00000037709.6 ENSMUST00000037709.7 ENSMUST00000037709.8 ENSMUST00000037709.9 NM_026281 Tm7sf3 uc009ese.1 uc009ese.2 uc009ese.3 Membrane ; Multi- pass membrane protein plasma membrane membrane integral component of membrane positive regulation of insulin secretion cellular response to unfolded protein negative regulation of programmed cell death uc009ese.1 uc009ese.2 uc009ese.3 
ENSMUST00000037722.9 Banf2 ENSMUST00000037722.9 BANF family member 2, transcript variant 1 (from RefSeq NM_207275.2) BAFL_MOUSE Bafl ENSMUST00000037722.1 ENSMUST00000037722.2 ENSMUST00000037722.3 ENSMUST00000037722.4 ENSMUST00000037722.5 ENSMUST00000037722.6 ENSMUST00000037722.7 ENSMUST00000037722.8 NM_207275 Q8BVR0 uc008mqn.1 uc008mqn.2 uc008mqn.3 May play a role in BANF1 regulation and influence tissue- specific roles of BANF1. Homodimer. Heterodimerizes with BANF1 (By similarity). Nucleus. Cytoplasm DNA binding nucleus nucleoplasm cytoplasm chromosome segregation chromosome condensation uc008mqn.1 uc008mqn.2 uc008mqn.3 
ENSMUST00000037726.14 Tmtc4 ENSMUST00000037726.14 transmembrane and tetratricopeptide repeat containing 4, transcript variant 2 (from RefSeq NM_028651.3) ENSMUST00000037726.1 ENSMUST00000037726.10 ENSMUST00000037726.11 ENSMUST00000037726.12 ENSMUST00000037726.13 ENSMUST00000037726.2 ENSMUST00000037726.3 ENSMUST00000037726.4 ENSMUST00000037726.5 ENSMUST00000037726.6 ENSMUST00000037726.7 ENSMUST00000037726.8 ENSMUST00000037726.9 NM_028651 Q8BG19 Q8BT03 Q8C4D2 Q8CAC3 Q8K0I2 Q9CS83 Q9D5P3 TMTC4_MOUSE uc007vbk.1 uc007vbk.2 uc007vbk.3 Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3. Reaction=a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3- O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+); Xref=Rhea:RHEA:17377, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:13546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:137321; EC=2.4.1.109; Evidence=; Reaction=a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+); Xref=Rhea:RHEA:53396, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13547, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:137323; EC=2.4.1.109; Evidence=; Protein modification; protein glycosylation. Membrane ; Multi-pass membrane protein Endoplasmic reticulum Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BG19-1; Sequence=Displayed; Name=2; IsoId=Q8BG19-2; Sequence=VSP_023625, VSP_023626; Name=3; IsoId=Q8BG19-3; Sequence=VSP_023624; Belongs to the TMTC family. Sequence=AAH31368.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC30236.1; Type=Frameshift; Evidence=; Sequence=BAC38520.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; mannosyltransferase activity dolichyl-phosphate-mannose-protein mannosyltransferase activity cellular_component endoplasmic reticulum protein glycosylation membrane integral component of membrane transferase activity protein O-linked mannosylation uc007vbk.1 uc007vbk.2 uc007vbk.3 
ENSMUST00000037728.13 Nlrp4c ENSMUST00000037728.13 NLR family, pyrin domain containing 4C (from RefSeq NM_031389.2) ENSMUST00000037728.1 ENSMUST00000037728.10 ENSMUST00000037728.11 ENSMUST00000037728.12 ENSMUST00000037728.2 ENSMUST00000037728.3 ENSMUST00000037728.4 ENSMUST00000037728.5 ENSMUST00000037728.6 ENSMUST00000037728.7 ENSMUST00000037728.8 ENSMUST00000037728.9 NAL4C_MOUSE NM_031389 Nalp4c Q3TKR3 Q66X27 uc009fan.1 uc009fan.2 uc009fan.3 uc009fan.4 May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Belongs to the NLRP family. nucleotide binding molecular_function ATP binding inflammatory response biological_process uc009fan.1 uc009fan.2 uc009fan.3 uc009fan.4 
ENSMUST00000037739.8 Gnl3 ENSMUST00000037739.8 guanine nucleotide binding protein nucleolar 3, transcript variant 1 (from RefSeq NM_153547.6) ENSMUST00000037739.1 ENSMUST00000037739.2 ENSMUST00000037739.3 ENSMUST00000037739.4 ENSMUST00000037739.5 ENSMUST00000037739.6 ENSMUST00000037739.7 GNL3_MOUSE NM_153547 Ns Q811R9 Q811S8 Q8BK21 Q8CI11 uc007swi.1 uc007swi.2 uc007swi.3 uc007swi.4 uc007swi.5 May be required to maintain the proliferative capacity of stem cells (By similarity). Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation. Interacts with MDM2; this interaction stabilizes MDM2 (PubMed:21132010). Interaction with MDM2 occurs in the nucleoplasm and is triggered by a nucleolar release mechanism, such as mitosis-induced nucleolar disassembly (PubMed:21132010). Indirectly interacts with TP53, via MDM2-binding (By similarity). Interacts with TSC22D1 isoform 2 (By similarity). Nucleus Nucleus, nucleolus Note=Shuttles between the nucleus and nucleolus. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=Q8CI11-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q8CI11-2; Sequence=VSP_013412; Expressed in the adult bone marrow population that is enriched in hematopoietic stem cells. Expressed at 8.5 dpc and 10.5 dpc in the cerebral cortex; expression declines rapidly from this point. The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis (By similarity). In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern. Belongs to the TRAFAC class YlqF/YawG GTPase family. nucleotide binding protein binding GTP binding nucleus nucleoplasm nucleolus cell proliferation nuclear body stem cell division stem cell population maintenance positive regulation of telomere maintenance positive regulation of protein sumoylation regulation of cell proliferation mRNA 5'-UTR binding positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of protein localization to chromosome, telomeric region uc007swi.1 uc007swi.2 uc007swi.3 uc007swi.4 uc007swi.5 
ENSMUST00000037746.8 Tlx3 ENSMUST00000037746.8 T cell leukemia, homeobox 3 (from RefSeq NM_019916.2) ENSMUST00000037746.1 ENSMUST00000037746.2 ENSMUST00000037746.3 ENSMUST00000037746.4 ENSMUST00000037746.5 ENSMUST00000037746.6 ENSMUST00000037746.7 Hox11l2 NM_019916 O55144 Q5SQB4 Rnx TLX3_MOUSE Tlx1l2 uc007ikg.1 uc007ikg.2 uc007ikg.3 uc007ikg.4 Nucleus cell fate specification neuron migration regulation of respiratory gaseous exchange by neurological system process DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development central nervous system development respiratory gaseous exchange neuron differentiation sequence-specific DNA binding negative regulation of neuron differentiation neuron fate specification uc007ikg.1 uc007ikg.2 uc007ikg.3 uc007ikg.4 
ENSMUST00000037748.9 Hnrnpu ENSMUST00000037748.9 heterogeneous nuclear ribonucleoprotein U, transcript variant 1 (from RefSeq NM_016805.3) ENSMUST00000037748.1 ENSMUST00000037748.2 ENSMUST00000037748.3 ENSMUST00000037748.4 ENSMUST00000037748.5 ENSMUST00000037748.6 ENSMUST00000037748.7 ENSMUST00000037748.8 G3XA10 HNRPU_MOUSE Hnrnpu Hnrpu NM_016805 Q8VEK3 Q9R205 uc011wxl.1 uc011wxl.2 uc011wxl.3 DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:20833368, PubMed:21235343, PubMed:22162999, PubMed:26244333). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (By similarity). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (PubMed:20833368, PubMed:26244333). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:21235343, PubMed:22162999). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner. Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation. Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus. Negatively regulates glucocorticoid-mediated transcriptional activation (By similarity). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (PubMed:21235343). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (By similarity). Participates in the circadian regulation of the core clock component BMAL1 transcription (PubMed:18332112). Plays a role in the regulation of telomere length. Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis. Plays a role in mRNA stability. Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR). Plays a role in mitotic cell cycle regulation. Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression. Phosphorylation at Ser-58 by PLK1 is required for chromosome alignement and segregation and progression through mitosis. Contributes also to the targeting of AURKA to mitotic spindle MTs. Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides. Binds to chromatin-associated RNAs (caRNAs). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin- associated RNAs (caRNAs)-dependent manner (By similarity). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (PubMed:20833368, PubMed:26244333). Binds the long non-coding H19 RNA. Binds to SMN1/2 pre-mRNAs at G/U-rich regions. Binds to small nuclear RNAs (snRNAs). Binds to the 3'-UTR of TNFA mRNA (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (PubMed:21235343). Required for embryonic development (PubMed:16022389). Binds to brown fat long non- coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (PubMed:28784777). Oligomer (via ATPase domain and RNA-binding RGG-box region); oligomerization occurs upon ATP-binding in a chromatin-associated RNAs (caRNAs)- and transcription-dependent manner and is required for chromatin decompaction. ATP hydrolysis is required to cycle from an oligomeric to monomeric state to compact chromatin. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Associates with heterogeneous nuclear ribonucleoprotein (hnRNP) particles (By similarity). Associates (via middle region) with the C-terminal domain (CTD) RNA polymerase II (Pol II) holoenzyme; this association occurs in a RNA-independent manner (PubMed:21235343). Associates (via middle region) with the core-TFIIH basal transcription factor complex; this association inhibits the CTD phosphorylation of RNA polymerase II holoenzyme by down-regulating TFIIH kinase activity. Associates with the telomerase holoenzyme complex. Associates with spindle microtubules (MTs) in a TPX2-dependent manner. Interacts (via C-terminus) with actin; this interaction is direct and mediates association with the phosphorylated CTD of RNA polymerase II and is disrupted in presence of the long non-coding H19 RNA. Interacts with AURKA. Interacts (via C-terminus) with CBX5; this interaction is, at least in part, RNA-dependent. Interacts with CR2 (By similarity). Interacts with CRY1 (PubMed:19129230). Interacts (via C- terminus) with EP300; this interaction enhances DNA-binding to nuclear scaffold/matrix attachment region (S/MAR) elements. Interacts with ERBB4. Interacts with GEMIN5. Interacts with IGF2BP1. Interacts with IGF2BP2 and IGF2BP3. Interacts with NCL; this interaction occurs during mitosis. Interacts (via C-terminus) with NR3C1 (via C-terminus). Interacts with PLK1; this interaction induces phosphorylation of HNRNPU at Ser-58 in mitosis. Interacts with POU3F4 (By similarity). Interacts with SMARCA4; this interaction occurs in embryonic stem cells and stimulates global Pol II-mediated transcription (PubMed:22162999). Interacts (via C-terminus) with TOP2A; this interaction protects the topoisomerase TOP2A from degradation and positively regulates the relaxation of supercoiled DNA by TOP2A in a RNA-dependent manner. Interacts with TPX2; this interaction recruits HNRNPU to spindle microtubules (MTs). Interacts with UBQLN2 (By similarity). Interacts (via RNA-binding RGG-box region) with ZBTB7B; the interaction facilitates the recruitment of long non-coding RNA Blnc1 by ZBTB7B (PubMed:28784777). Interacts with ERCC6 (By similarity). Q8VEK3; Q3TKT4: Smarca4; NbExp=3; IntAct=EBI-529674, EBI-1210244; Nucleus cleus matrix Chromosome Nucleus speckle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Midbody Cytoplasm Cell surface Cytoplasmic granule Note=Localizes at inactive X chromosome (Xi) regions (PubMed:20833368). Localizes in the nucleus during interphase. At metaphase, localizes with mitotic spindle microtubules (MTs). At anaphase, localizes in the mitotic spindle midzone. Localizes in spindle MTs proximal to spindle poles in a TPX2- and AURKA-dependent manner. The Ser-58 phosphorylated form localizes to centrosomes during prophase and metaphase, to mitotic spindles in anaphase and to the midbody during cytokinesis (By similarity). Colocalizes with SMARCA4 in the nucleus (PubMed:22162999). Colocalizes with CBX5 in the nucleus. Colocalizes with NR3C1 in nuclear speckles. Localized in cytoplasmic ribonucleoprotein (RNP) granules containing untranslated mRNAs (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VEK3-1; Sequence=Displayed; Name=2; IsoId=Q8VEK3-2; Sequence=VSP_059004; The SAP domain is necessary for specific binding to nuclear scaffold/matrix attachment region (S/MAR) elements in DNA. The RNA- binding RGG-box region is necessary for its association with inactive X chromosome (Xi) regions and to chromatin-associated RNAs (caRNAs) (By similarity). Both the DNA-binding domain SAP and the RNA-binding RGG- box region are necessary for the localization of Xist RNA on the Xi (PubMed:20833368). The ATPase and RNA-binding RGG-box regions are necessary for oligomerization (By similarity). Cleaved at Asp-94 by CASP3 during T-cell apoptosis, resulting in a loss of DNA- and chromatin-binding activities. Extensively phosphorylated. Phosphorylated on Ser-58 by PLK1 and dephosphorylated by protein phosphatase 2A (PP2A) in mitosis. Arg-709 and Arg-715 are dimethylated, probably to asymmetric dimethylarginine. Citrullinated by PADI4. Mice exhibit early embryonic lethality between 9.5 and 11.5 dpc (PubMed:16022389). Mice show retarded development of embryonic ectoderm at 6.5 dpc and growth retardation beginning at 7.5 dpc (PubMed:16022389). negative regulation of transcription from RNA polymerase II promoter nucleotide binding nuclear chromosome regulation of alternative mRNA splicing, via spliceosome chromosome, centromeric region kinetochore condensed chromosome kinetochore spindle pole RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core binding TFIIH-class transcription factor binding DNA binding chromatin binding double-stranded DNA binding single-stranded DNA binding transcription corepressor activity RNA binding double-stranded RNA binding single-stranded RNA binding mRNA 3'-UTR binding actin binding protein binding ATP binding nucleus nucleoplasm spliceosomal complex chromosome telomerase holoenzyme complex cytoplasm centrosome microtubule organizing center spindle cytoskeleton chromatin organization mRNA processing cell cycle multicellular organism development regulation of mitotic cell cycle poly(A) binding RNA splicing dosage compensation by inactivation of X chromosome cell surface positive regulation of gene expression nuclear matrix nuclear speck snRNA binding poly(C) RNA binding cell differentiation midbody chromatin DNA binding negative regulation of telomere maintenance via telomerase dendrite cytoplasm circadian regulation of gene expression macromolecular complex negative regulation of kinase activity poly(G) binding negative regulation of transcription elongation from RNA polymerase II promoter pre-mRNA binding cytoplasmic ribonucleoprotein granule identical protein binding ribonucleoprotein complex binding sequence-specific DNA binding macromolecular complex binding positive regulation of transcription from RNA polymerase II promoter mRNA stabilization rhythmic process cell division maintenance of protein location in nucleus cardiac muscle cell development telomerase RNA binding CRD-mediated mRNA stabilization CRD-mediated mRNA stability complex catalytic step 2 spliceosome cellular response to glucocorticoid stimulus cellular response to dexamethasone stimulus mitotic spindle positive regulation of brown fat cell differentiation RNA polymerase II transcription factor complex inactive sex chromosome dendritic transport of messenger ribonucleoprotein complex RNA polymerase II C-terminal domain binding regulation of mitotic spindle assembly regulation of chromatin organization positive regulation of attachment of mitotic spindle microtubules to kinetochore protein localization to spindle microtubule mitotic spindle midzone RNA localization to chromatin mitotic spindle microtubule cellular response to leukemia inhibitory factor sequence-specific double-stranded DNA binding promoter-specific chromatin binding adaptive thermogenesis ribonucleoprotein complex positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity positive regulation of stem cell proliferation negative regulation of stem cell differentiation uc011wxl.1 uc011wxl.2 uc011wxl.3 
ENSMUST00000037763.11 Ythdc2 ENSMUST00000037763.11 YTH domain containing 2 (from RefSeq NM_001163013.2) B2RR83 ENSMUST00000037763.1 ENSMUST00000037763.10 ENSMUST00000037763.2 ENSMUST00000037763.3 ENSMUST00000037763.4 ENSMUST00000037763.5 ENSMUST00000037763.6 ENSMUST00000037763.7 ENSMUST00000037763.8 ENSMUST00000037763.9 NM_001163013 YTDC2_MOUSE Ythdc2 uc008evb.1 uc008evb.2 uc008evb.3 uc008evb.4 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:28380054, PubMed:28809393, PubMed:29033321, PubMed:29087293, PubMed:29360036, PubMed:32470506). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non- coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:29360036). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (PubMed:29033321). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (PubMed:28809393, PubMed:29033321). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Interacts with MEIOC; binds transcripts that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normally (PubMed:28380054, PubMed:29087293). Interacts (via ANK repeats) with XRN1 (By similarity). Interacts with ZCCHC4 (By similarity). Associates with the small ribosomal subunit (By similarity). Interacts with RBM46 (PubMed:36001654). B2RR83; A2AG06: Meioc; NbExp=4; IntAct=EBI-8572369, EBI-11664020; Cytoplasm toplasm, perinuclear region Present in male and female germ cells (at protein level) (PubMed:29033321, PubMed:32470506). Highly expressed in testis (PubMed:28809393, PubMed:29033321, PubMed:29087293, PubMed:29360036). Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (at protein level) (PubMed:29087293). Expression rises between 7 and 12 d.p.p. and remains steady through adulthood. The YTH domain mediates RNA-binding. It recognizes and binds N6-methyladenosine (m6A)-containing RNAs. Mice are viable and reach adulthood (PubMed:28809393, PubMed:29087293, PubMed:29033321). However, both male and female mice are infertile; male mice have smaller testes, and female mice have smaller ovaries and show progressive loss of germ cells (PubMed:28809393, PubMed:29087293, PubMed:29033321). Mutant germ cells enter meiosis but proceed prematurely to aberrant metaphase and apoptosis, and display defects in transitioning from spermatogonial to meiotic gene expression programs (PubMed:29087293, PubMed:29033321). Mutant testes reveal an up-regulation of N6-methyladenosine (m6A)- enriched transcripts (PubMed:29033321). 'Ketu' is a harbinger of misfortune in Vedic mythology (PubMed:29360036). Belongs to the DEAD box helicase family. DEAH subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity protein binding ATP binding nucleus cytoplasm endoplasmic reticulum spermatogenesis spermatid development RNA-dependent ATPase activity hydrolase activity cell differentiation 3'-5' RNA helicase activity response to tumor necrosis factor ribonucleoprotein granule positive regulation by host of viral genome replication oogenesis oocyte development meiotic cell cycle germline cell cycle switching, mitotic to meiotic cell cycle RNA polymerase binding response to interleukin-1 N6-methyladenosine-containing RNA binding uc008evb.1 uc008evb.2 uc008evb.3 uc008evb.4 
ENSMUST00000037783.7 Ccdc174 ENSMUST00000037783.7 coiled-coil domain containing 174 (from RefSeq NM_172730.2) A0A0R4J0L8 A0A0R4J0L8_MOUSE Ccdc174 ENSMUST00000037783.1 ENSMUST00000037783.2 ENSMUST00000037783.3 ENSMUST00000037783.4 ENSMUST00000037783.5 ENSMUST00000037783.6 NM_172730 uc009cyk.1 uc009cyk.2 uc009cyk.3 nucleus nucleoplasm uc009cyk.1 uc009cyk.2 uc009cyk.3 
ENSMUST00000037788.6 Pomt2 ENSMUST00000037788.6 protein-O-mannosyltransferase 2 (from RefSeq NM_153415.4) ENSMUST00000037788.1 ENSMUST00000037788.2 ENSMUST00000037788.3 ENSMUST00000037788.4 ENSMUST00000037788.5 NM_153415 POMT2_MOUSE Q8BGQ4 Q8R4Z0 uc007oij.1 uc007oij.2 uc007oij.3 This gene encodes an integral membrane protein that belongs to the dolichyl-phosphate-mannose-protein mannosyltransferase family. The encoded enzyme is found in the membrane of the endoplasmic reticulum. This protein is a component of the protein O-mannosyltransferase enzyme complex which is involved in modification of the protein alpha-dystroglycan. Mutations in the human gene are a cause of different forms of muscular dystrophy-dystroglycanopathy (MDDG), type A2 (also known as Walker-Warburg syndrome), type B2 and type C2 (also known as limb-girdle muscular dystrophy). [provided by RefSeq, Sep 2015]. ##Evidence-Data-START## Transcript exon combination :: AY090481.1, AY090482.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins. Reaction=a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3- O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+); Xref=Rhea:RHEA:17377, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:13546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:137321; EC=2.4.1.109; Reaction=a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+); Xref=Rhea:RHEA:53396, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13547, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:137323; EC=2.4.1.109; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BGQ4-1; Sequence=Displayed; Name=2; IsoId=Q8BGQ4-2; Sequence=VSP_007597, VSP_007598, VSP_007599; Name=3; IsoId=Q8BGQ4-3; Sequence=VSP_007597; Ubiquitous. Highly expressed in the acrosome of cap phase spermatids, in spermatocytes and liver. Isoform 1 seems to be testis-specific. N-glycosylated. [Isoform 3]: May be produced by use of an alternative promoter. Belongs to the glycosyltransferase 39 family. mannosyltransferase activity dolichyl-phosphate-mannose-protein mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation protein O-linked glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein O-linked mannosylation ER-associated misfolded protein catabolic process positive regulation of protein O-linked glycosylation uc007oij.1 uc007oij.2 uc007oij.3 
ENSMUST00000037796.14 Gmppa ENSMUST00000037796.14 GDP-mannose pyrophosphorylase A, transcript variant 1 (from RefSeq NM_133708.4) ENSMUST00000037796.1 ENSMUST00000037796.10 ENSMUST00000037796.11 ENSMUST00000037796.12 ENSMUST00000037796.13 ENSMUST00000037796.2 ENSMUST00000037796.3 ENSMUST00000037796.4 ENSMUST00000037796.5 ENSMUST00000037796.6 ENSMUST00000037796.7 ENSMUST00000037796.8 ENSMUST00000037796.9 GMPPA_MOUSE NM_133708 Q3UCM2 Q922H4 uc007bpd.1 uc007bpd.2 uc007bpd.3 May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. Associates with GMPPB. Cytoplasm Widely expressed. Belongs to the transferase hexapeptide repeat family. GMPPA is a close homolog of GMPPB, that has been shown to catalyze the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. It has been hypothesized that GMPPA might serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. Alignment of GMPPAs and GMPPBs from various species shows that GMPPAs are characterized by a 2 amino acid-insertion (residues 11-12) in a highly conserved motif that borders the catalytic pocket and binds the nucleotide substrate in homologous enzymes. This insertion might inactivate the ancestral catalytic site, converting it to an allosteric site (PubMed:24035193). molecular_function cellular_component cytoplasm biosynthetic process transferase activity nucleotidyltransferase activity uc007bpd.1 uc007bpd.2 uc007bpd.3 
ENSMUST00000037798.8 Slc24a1 ENSMUST00000037798.8 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1, transcript variant 1 (from RefSeq NM_144813.3) ENSMUST00000037798.1 ENSMUST00000037798.2 ENSMUST00000037798.3 ENSMUST00000037798.4 ENSMUST00000037798.5 ENSMUST00000037798.6 ENSMUST00000037798.7 NCKX1_MOUSE NM_144813 Nckx1 Q91WD8 Slc24a1 uc009qcl.1 uc009qcl.2 Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29108; Evidence=; Cell membrane ; Multi-pass membrane protein The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration and topology. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. calcium channel activity integral component of plasma membrane calcium ion transport cellular calcium ion homeostasis visual perception calcium, potassium:sodium antiporter activity membrane integral component of membrane intrinsic component of plasma membrane sodium ion transmembrane transport transmembrane transport long-term synaptic potentiation long term synaptic depression calcium ion transmembrane transport potassium ion transmembrane transport anion transmembrane transport uc009qcl.1 uc009qcl.2 
ENSMUST00000037807.3 Vax2 ENSMUST00000037807.3 ventral anterior homeobox 2 (from RefSeq NM_011912.4) ENSMUST00000037807.1 ENSMUST00000037807.2 NM_011912 Q9WTP9 VAX2_MOUSE Vex uc009cob.1 uc009cob.2 uc009cob.3 Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle. May be a regulator of axial polarization in the retina. Nucleus Expressed in the developing and mature retina. At 9.5 dpc, expressed solely in the ventral halves of the optic stalks and vesicles without proximo-distal restriction. Expression in the optic stalk diminishes after 11.5 dpc and becomes restricted to the inner layer of optic cup in its ventral half. Expression persists in the ventral halves of all neural retina layers (inner and outer nuclear layer) at 14.5 dpc and 16.5 dpc, and the ganglion cell layer, inner nuclear layer and photoreceptor layer in the adult. Belongs to the EMX homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development axonogenesis central nervous system development visual perception dorsal/ventral axis specification Wnt signaling pathway neuron differentiation forebrain development chromatin DNA binding camera-type eye development sequence-specific DNA binding embryonic eye morphogenesis retina development in camera-type eye uc009cob.1 uc009cob.2 uc009cob.3 
ENSMUST00000037811.13 Apob ENSMUST00000037811.13 apolipoprotein B (from RefSeq NM_009693.2) APOB_MOUSE E9Q414 ENSMUST00000037811.1 ENSMUST00000037811.10 ENSMUST00000037811.11 ENSMUST00000037811.12 ENSMUST00000037811.2 ENSMUST00000037811.3 ENSMUST00000037811.4 ENSMUST00000037811.5 ENSMUST00000037811.6 ENSMUST00000037811.7 ENSMUST00000037811.8 ENSMUST00000037811.9 NM_009693 Q3UH74 Q497D8 Q61314 Q61318 Q8CGG8 uc007mzf.1 uc007mzf.2 uc007mzf.3 uc007mzf.4 This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the mouse apoB-48 isoform is also found in mouse liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2179 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the reference strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous human and rat data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein undergoes RNA editing :: PMID: 16920700 ##RefSeq-Attributes-END## Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Interacts with PCSK9 (By similarity). Interacts with MTTP (By similarity). Interacts with AUP1 (By similarity). Interacts with CIDEB (PubMed:19187774, PubMed:23297397). Cytoplasm Secreted Lipid droplet Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle. Modified_positions=2179 ; Note=The stop codon (UAA) at position 2179 is created by an APOBEC1- containing mRNA editing complex. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL (By similarity). ; Sequence=AAI41358.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI41361.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE27983.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; in utero embryonic development lipid transporter activity phospholipid binding extracellular region extracellular space cytoplasm endoplasmic reticulum cytosol lipid metabolic process triglyceride mobilization lipid transport spermatogenesis nervous system development heparin binding steroid metabolic process cholesterol metabolic process fertilization response to virus response to carbohydrate post-embryonic development response to organic substance response to selenium ion positive regulation of gene expression positive regulation of macrophage derived foam cell differentiation positive regulation of lipid storage positive regulation of cholesterol storage vesicle membrane lipid catabolic process triglyceride catabolic process cholesterol transport flagellated sperm motility vesicle lumen response to estradiol response to lipopolysaccharide cholesterol efflux mature chylomicron very-low-density lipoprotein particle low-density lipoprotein particle intermediate-density lipoprotein particle high-density lipoprotein particle low-density lipoprotein particle remodeling low-density lipoprotein particle clearance lipase binding lipoprotein metabolic process lipoprotein biosynthetic process lipoprotein catabolic process chylomicron cholesterol homeostasis lipoprotein transport neuronal cell body intracellular membrane-bounded organelle regulation of cholesterol biosynthetic process artery morphogenesis low-density lipoprotein particle receptor binding endoplasmic reticulum exit site cellular response to tumor necrosis factor cellular response to prostaglandin stimulus uc007mzf.1 uc007mzf.2 uc007mzf.3 uc007mzf.4 
ENSMUST00000037813.5 Gnaz ENSMUST00000037813.5 guanine nucleotide binding protein, alpha z subunit, transcript variant 1 (from RefSeq NM_010311.4) ENSMUST00000037813.1 ENSMUST00000037813.2 ENSMUST00000037813.3 ENSMUST00000037813.4 Gnaz NM_010311 Q542R8 Q542R8_MOUSE uc007fpt.1 uc007fpt.2 uc007fpt.3 Belongs to the G-alpha family. G(i/o/t/z) subfamily. nucleotide binding GTPase activity GTP binding cytosol plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway guanyl nucleotide binding G-protein beta/gamma-subunit complex binding G-protein coupled serotonin receptor binding metal ion binding uc007fpt.1 uc007fpt.2 uc007fpt.3 
ENSMUST00000037814.8 Cmtm5 ENSMUST00000037814.8 CKLF-like MARVEL transmembrane domain containing 5, transcript variant 2 (from RefSeq NM_026066.2) CKLF5_MOUSE Cklfsf5 ENSMUST00000037814.1 ENSMUST00000037814.2 ENSMUST00000037814.3 ENSMUST00000037814.4 ENSMUST00000037814.5 ENSMUST00000037814.6 ENSMUST00000037814.7 NM_026066 Q9D6G9 Q9DB66 uc007txo.1 uc007txo.2 uc007txo.3 Membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D6G9-1; Sequence=Displayed; Name=2; IsoId=Q9D6G9-2; Sequence=VSP_008266; Belongs to the chemokine-like factor family. molecular_function cytokine activity extracellular space chemotaxis signal transduction membrane integral component of membrane negative regulation of myoblast differentiation uc007txo.1 uc007txo.2 uc007txo.3 
ENSMUST00000037820.3 Hdhd3 ENSMUST00000037820.3 haloacid dehalogenase-like hydrolase domain containing 3 (from RefSeq NM_024257.1) ENSMUST00000037820.1 ENSMUST00000037820.2 HDHD3_MOUSE NM_024257 Q9CYW4 uc008tey.1 uc008tey.2 uc008tey.3 Belongs to the HAD-like hydrolase superfamily. mitochondrion hydrolase activity uc008tey.1 uc008tey.2 uc008tey.3 
ENSMUST00000037824.6 Foxh1 ENSMUST00000037824.6 forkhead box H1 (from RefSeq NM_007989.4) ENSMUST00000037824.1 ENSMUST00000037824.2 ENSMUST00000037824.3 ENSMUST00000037824.4 ENSMUST00000037824.5 Foxh1 NM_007989 Q0VEP8 Q0VEP8_MOUSE uc007wlm.1 uc007wlm.2 uc007wlm.3 uc007wlm.4 Nucleus nuclear chromatin DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated protein domain specific binding activin responsive factor complex negative regulation of intracellular estrogen receptor signaling pathway bHLH transcription factor binding negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter SMAD binding androgen receptor binding negative regulation of androgen receptor signaling pathway co-SMAD binding R-SMAD binding cellular response to cytokine stimulus uc007wlm.1 uc007wlm.2 uc007wlm.3 uc007wlm.4 
ENSMUST00000037827.10 Slc45a1 ENSMUST00000037827.10 solute carrier family 45, member 1, transcript variant 1 (from RefSeq NM_173774.4) Dnb5 ENSMUST00000037827.1 ENSMUST00000037827.2 ENSMUST00000037827.3 ENSMUST00000037827.4 ENSMUST00000037827.5 ENSMUST00000037827.6 ENSMUST00000037827.7 ENSMUST00000037827.8 ENSMUST00000037827.9 NM_173774 Q3TZ98 Q8BIV7 S45A1_MOUSE Slc45a1 uc008vxt.1 uc008vxt.2 uc008vxt.3 Proton-associated glucose transporter in the brain. Reaction=D-galactose(in) + H(+)(in) = D-galactose(out) + H(+)(out); Xref=Rhea:RHEA:29019, ChEBI:CHEBI:4139, ChEBI:CHEBI:15378; Evidence=; Reaction=D-glucose(out) + H(+)(out) = D-glucose(in) + H(+)(in); Xref=Rhea:RHEA:69556, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. Sequence=AK082651; Type=Frameshift; Evidence=; glucose transmembrane transporter activity integral component of plasma membrane sucrose:proton symporter activity carbohydrate transport symporter activity sucrose transport membrane integral component of membrane transmembrane transport glucose transmembrane transport uc008vxt.1 uc008vxt.2 uc008vxt.3 
ENSMUST00000037828.8 Ldlrap1 ENSMUST00000037828.8 low density lipoprotein receptor adaptor protein 1 (from RefSeq NM_145554.2) ARH_MOUSE Arh ENSMUST00000037828.1 ENSMUST00000037828.2 ENSMUST00000037828.3 ENSMUST00000037828.4 ENSMUST00000037828.5 ENSMUST00000037828.6 ENSMUST00000037828.7 Ldlrap1 NM_145554 Q3TW86 Q6NWV6 Q8C142 Q8VDQ0 uc012dmx.1 uc012dmx.2 uc012dmx.3 Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non- polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity). Interacts (via PID domain) with LDLR (via NPXY motif). Binds to soluble clathrin trimers. Interacts with AP2B1; the interaction mediates the association with the AP-2 complex (By similarity). Interacts with VLDLR (PubMed:12746448). Interacts with LRP2 (By similarity). Cytoplasm The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1. The PID domain mediates interaction with the NPXY internalization motif of LDLR. Mice are extremely sensitive to cholesterol intake. LDLR are expressed at normal levels, but are sequestered at the hepatocyte surface. LDL internalization defect is caused by the inability of the LDLR to enter the endocytic cycle. Sequence=AAH21467.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; beta-amyloid binding phosphotyrosine binding receptor binding protein binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm early endosome cytosol neurofilament lipid metabolic process endocytosis receptor-mediated endocytosis steroid metabolic process cholesterol metabolic process cytoplasmic side of plasma membrane basal plasma membrane positive regulation of signal transduction receptor signaling complex scaffold activity clathrin binding axon receptor internalization low-density lipoprotein particle clearance signaling adaptor activity AP-2 adaptor complex binding clathrin adaptor activity AP-1 adaptor complex binding cholesterol homeostasis amyloid precursor protein metabolic process regulation of protein binding positive regulation of receptor-mediated endocytosis low-density lipoprotein particle receptor binding recycling endosome cellular response to cytokine stimulus receptor-mediated endocytosis involved in cholesterol transport regulation of protein localization to plasma membrane positive regulation of vascular smooth muscle cell proliferation positive regulation of low-density lipoprotein particle clearance positive regulation of receptor-mediated endocytosis involved in cholesterol transport uc012dmx.1 uc012dmx.2 uc012dmx.3 
ENSMUST00000037831.14 H1f8 ENSMUST00000037831.14 H1.8 linker histone, transcript variant 1 (from RefSeq NM_138311.3) ENSMUST00000037831.1 ENSMUST00000037831.10 ENSMUST00000037831.11 ENSMUST00000037831.12 ENSMUST00000037831.13 ENSMUST00000037831.2 ENSMUST00000037831.3 ENSMUST00000037831.4 ENSMUST00000037831.5 ENSMUST00000037831.6 ENSMUST00000037831.7 ENSMUST00000037831.8 ENSMUST00000037831.9 H1.8 H18_MOUSE H1f8 H1foo H1oo NM_138311 Q8VIK3 uc009djl.1 uc009djl.2 uc009djl.3 uc009djl.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes and the encoded protein is expressed only in oocytes. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK135944.1, AY007195.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein replication-independent histone :: PMID: 24781148 ##RefSeq-Attributes-END## May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling. Cytoplasm Nucleus. Chromosome. Note=In the germinal vesicle oocyte, localizes to the condensed chromosomes. In the 1-cell embryo found in condensed maternal metaphase chromatin but not in the sperm head. Following second polar body extrusion, detected in the swollen sperm head as well as in the second polar body. Reduced expression in the nucleus in 2-cell embryo is seen as compared to 1-cell embryo. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha; IsoId=Q8VIK3-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q8VIK3-2; Sequence=VSP_034593; Oocyte-specific. Expressed as early as the germinal vesicle (GV) stage oocyte, and persists into the metaphase II stage oocyte, the oocytic polar bodies, and the 2-cell embryo, and disappears at the 4- to 8-cell embryonic stage. Belongs to the histone H1/H5 family. nucleosome female germ cell nucleus DNA binding double-stranded DNA binding nucleus chromosome cytoplasm nucleosome assembly regulation of transcription, DNA-templated nucleosome positioning chromosome condensation nucleosomal DNA binding negative regulation of chromatin silencing regulation of DNA methylation negative regulation of DNA recombination meiotic cell cycle negative regulation of stem cell differentiation nucleolus uc009djl.1 uc009djl.2 uc009djl.3 uc009djl.4 
ENSMUST00000037839.12 Zfand1 ENSMUST00000037839.12 zinc finger, AN1-type domain 1, transcript variant 1 (from RefSeq NM_025512.4) ENSMUST00000037839.1 ENSMUST00000037839.10 ENSMUST00000037839.11 ENSMUST00000037839.2 ENSMUST00000037839.3 ENSMUST00000037839.4 ENSMUST00000037839.5 ENSMUST00000037839.6 ENSMUST00000037839.7 ENSMUST00000037839.8 ENSMUST00000037839.9 NM_025512 Q8BFR6 Q8R3Y6 Q9D7H5 ZFAN1_MOUSE Zfand1 uc008ops.1 uc008ops.2 uc008ops.3 Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress. Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome. This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy. Associates with the 26S proteasome; this association occurs upon exposure to arsenite and is reduced in the presence of ATP. Interacts (via AN1-type 1 and 2 zinc fingers) with PSMD1; this interaction is increased upon arsenite treatment and occurs in an ATP- independent manner. Interacts with PSMC4. Interacts with PSMA1. Interacts (via its ubiquitin-like region) with VCP; this interaction occurs in an arsenite-dependent manner and is necessary for the recruitment of the ubiquitin-selective ATPase VCP to stress granules (SGs). Cytoplasm, Stress granule Note=Colocalizes with TIA1, G3BP1, VCP and 26S proteasome in cytoplasmic stress granules (SGs) in response to arsenite-induced stress treatment in a VCP-independent manner. Not localized in SGs in response to other heat- oxidative- or osmotic- induced stress treatments. Colocalizes with VCP in cytoplasmic speckles. The ubiquitin-like region is necessary for its localization to stress granules (SGs) in a VCP-independent manner. The AN1-type 1 and 2 zinc finger domains are necessary for the recruitment of the 26S proteasome to SGs. Both the AN1-type 1 and 2 zinc finger domains and the ubiquitin-like region are necessary for efficient SGs clearance upon specific arsenite-induced responses. cytoplasm zinc ion binding cytoplasmic stress granule stress granule disassembly metal ion binding proteasome binding positive regulation of intracellular protein transport cellular response to arsenite ion uc008ops.1 uc008ops.2 uc008ops.3 
ENSMUST00000037843.7 Ubald1 ENSMUST00000037843.7 UBA-like domain containing 1 (from RefSeq NM_145359.2) ENSMUST00000037843.1 ENSMUST00000037843.2 ENSMUST00000037843.3 ENSMUST00000037843.4 ENSMUST00000037843.5 ENSMUST00000037843.6 Fam100a NM_145359 Q0P6G5 Q6P3B2 UBAD1_MOUSE uc007yao.1 uc007yao.2 uc007yao.3 uc007yao.4 Belongs to the UBALD family. molecular_function cellular_component biological_process uc007yao.1 uc007yao.2 uc007yao.3 uc007yao.4 
ENSMUST00000037849.3 Ly6g5c ENSMUST00000037849.3 lymphocyte antigen 6 family member G5C (from RefSeq NM_148947.2) ENSMUST00000037849.1 ENSMUST00000037849.2 LY65C_MOUSE NM_148947 Q0D2G4 Q8K1T5 uc008cfr.1 uc008cfr.2 uc008cfr.3 May have a role in hematopoietic cell differentiation. Forms oligomers. Secreted Detected in adult brain. N-glycosylated. extracellular region external side of plasma membrane macromolecular complex identical protein binding protein homooligomerization uc008cfr.1 uc008cfr.2 uc008cfr.3 
ENSMUST00000037850.7 Snx2 ENSMUST00000037850.7 sorting nexin 2, transcript variant 1 (from RefSeq NM_026386.2) ENSMUST00000037850.1 ENSMUST00000037850.2 ENSMUST00000037850.3 ENSMUST00000037850.4 ENSMUST00000037850.5 ENSMUST00000037850.6 NM_026386 Q3UKW3 Q9CQV0 Q9CWK8 SNX2_MOUSE uc008exr.1 uc008exr.2 uc008exr.3 Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle- to-membrane remodeling activity. Required for retrograde endosome-to- TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (By similarity). Predominantly forms heterodimers with BAR domain-containing sorting nexins SNX5, SNX6 and SNX32; can self-associate to form homodimers. The heterodimers are proposed to self-assemble into helical arrays on the membrane to stabilize and expand local membrane curvature underlying endosomal tubule formation. Thought to be a component of the originally described retromer complex (also called SNX-BAR retromer) which is a pentamer containing the heterotrimeric retromer cargo- selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. Interacts with SNX5, SNX6, SNX32, VPS26A, VPS29, VPS35, FNBP1, KALRN, RHOG (GDP-bound form) (By similarity). Early endosome membrane; Peripheral membrane protein; Cytoplasmic side Cell projection, lamellipodium. Note=Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles. Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (By similarity). The BAR domain is able to sense membrane curvature upon dimerization. Membrane remodeling seems to implicate insertion of a N- terminal amphipathic helix (AH) in the membrane (By similarity). No visible phenotype. Mice are born at the expected Mendelian ratio and are fertile. Mice lacking both Snx1 and Snx2 die during embryonic development, around 9.5 and 11.5 dpc. Belongs to the sorting nexin family. epidermal growth factor receptor binding insulin receptor binding cytoplasm lysosome endosome cytosol intracellular protein transport endocytosis lipid binding endosome membrane protein transport membrane lamellipodium retromer complex retromer, tubulation complex early endosome membrane macromolecular complex early endosome to Golgi transport phosphatidylinositol binding retrograde transport, endosome to Golgi protein homodimerization activity cell projection protein heterodimerization activity protein oligomerization lamellipodium morphogenesis transferrin receptor binding leptin receptor binding uc008exr.1 uc008exr.2 uc008exr.3 
ENSMUST00000037853.5 Poglut3 ENSMUST00000037853.5 protein O-glucosyltransferase 3 (from RefSeq NM_212445.2) ENSMUST00000037853.1 ENSMUST00000037853.2 ENSMUST00000037853.3 ENSMUST00000037853.4 G5E897 Kdelc2 NM_212445 PLGT3_MOUSE Q8C6F3 uc009pmb.1 uc009pmb.2 uc009pmb.3 Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway. Reaction=L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O- (beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:58116, Rhea:RHEA-COMP:14610, Rhea:RHEA-COMP:16010, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885, ChEBI:CHEBI:140576; Evidence=; Reaction=L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O- (beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:62016, Rhea:RHEA-COMP:16010, Rhea:RHEA-COMP:16011, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:132085; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum lumen Belongs to the KDELC family. molecular_function cellular_component endoplasmic reticulum endoplasmic reticulum lumen protein glycosylation biological_process transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via serine protein xylosyltransferase activity UDP-glucosyltransferase activity UDP-xylosyltransferase activity glucosyltransferase activity uc009pmb.1 uc009pmb.2 uc009pmb.3 
ENSMUST00000037854.15 Diaph2 ENSMUST00000037854.15 diaphanous related formin 2 (from RefSeq NM_172493.3) Diap2 Diaph2 ENSMUST00000037854.1 ENSMUST00000037854.10 ENSMUST00000037854.11 ENSMUST00000037854.12 ENSMUST00000037854.13 ENSMUST00000037854.14 ENSMUST00000037854.2 ENSMUST00000037854.3 ENSMUST00000037854.4 ENSMUST00000037854.5 ENSMUST00000037854.6 ENSMUST00000037854.7 ENSMUST00000037854.8 ENSMUST00000037854.9 NM_172493 Q6W4W7 Q6W4W7_MOUSE uc009uet.1 uc009uet.2 uc009uet.3 uc009uet.4 uc009uet.5 Belongs to the formin homology family. Diaphanous subfamily. actin binding nucleolus endoplasmic reticulum actin filament organization female gamete generation cellular component organization Rho GTPase binding actin cytoskeleton organization intracellular membrane-bounded organelle uc009uet.1 uc009uet.2 uc009uet.3 uc009uet.4 uc009uet.5 
ENSMUST00000037863.6 Il25 ENSMUST00000037863.6 interleukin 25 (from RefSeq NM_080729.3) ENSMUST00000037863.1 ENSMUST00000037863.2 ENSMUST00000037863.3 ENSMUST00000037863.4 ENSMUST00000037863.5 IL25_MOUSE Il17e NM_080729 Q8VHH8 uc007txn.1 uc007txn.2 uc007txn.3 uc007txn.4 Cytokine produced by various cells such as eosinophils, T- helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production (PubMed:35615348, PubMed:11754819). Promotes and augments T- helper type 2 responses locally or systemically (PubMed:35615348). Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction (PubMed:18768888). In turn, stimulates the JAK2- STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13. Induces also the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways. Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13. Secreted Mice display mitigated inflammatory responses and Th2 responses in house dust mite/HDM-induced asthma model. Belongs to the IL-17 family. inflammatory response to antigenic stimulus cytokine activity extracellular region inflammatory response signal transduction response to fungus response to nematode eosinophil differentiation interleukin-17E receptor binding interleukin-13 production interleukin-5 production positive regulation of transcription from RNA polymerase II promoter uc007txn.1 uc007txn.2 uc007txn.3 uc007txn.4 
ENSMUST00000037865.13 Atp6v0a2 ENSMUST00000037865.13 ATPase, H+ transporting, lysosomal V0 subunit A2 (from RefSeq NM_011596.5) A4FU82 Atp6n1b ENSMUST00000037865.1 ENSMUST00000037865.10 ENSMUST00000037865.11 ENSMUST00000037865.12 ENSMUST00000037865.2 ENSMUST00000037865.3 ENSMUST00000037865.4 ENSMUST00000037865.5 ENSMUST00000037865.6 ENSMUST00000037865.7 ENSMUST00000037865.8 ENSMUST00000037865.9 NM_011596 P15920 Q3U2X3 Q8VHU0 Q9JHJ2 Tj6 VPP2_MOUSE uc029voj.1 uc029voj.2 uc029voj.3 This gene encodes a subunit of vacuolar ATPase, a multimeric enzyme that localizes to intracellular vesicles and to the plasma membrane of specialized cells. The encoded protein is a component of the V(0) domain, which functions in proton translocation across membranes. Function of this gene is important in fetal-specific immune suppression during pregnancy. [provided by RefSeq, May 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC112905.1, SRR1660815.214226.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (PubMed:16415858). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Directly interacts with PSCD2 through its N-terminal cytosolic tail in an intra-endosomal acidification-dependent manner (PubMed:16415858). Disruption of this interaction results in the inhibition of endocytosis (PubMed:16415858). Interacts with SPAAR (By similarity). P15920; P63034: Cyth2; NbExp=5; IntAct=EBI-988456, EBI-988425; Cell membrane ; Multi-pass membrane protein Endosome membrane Note=In kidney proximal tubules, detected in subapical early endosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P15920-1; Sequence=Displayed; Name=2; IsoId=P15920-2; Sequence=VSP_032088; Relatively high expression in kidney and liver. Lower levels in the spleen, testis, and skeletal muscle. Also expressed in the thymus. Belongs to the V-ATPase 116 kDa subunit family. Sequence=AAL57303.1; Type=Erroneous initiation; Evidence=; vacuolar proton-transporting V-type ATPase, V0 domain acrosomal vesicle protein binding endosome plasma membrane ion transport cellular iron ion homeostasis vacuolar acidification endosome membrane hydrogen ion transmembrane transporter activity membrane integral component of membrane vacuolar proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V0 domain cellular response to increased oxygen levels intracellular organelle proton-transporting ATPase activity, rotational mechanism perinuclear region of cytoplasm ATPase binding hydrogen ion transmembrane transport uc029voj.1 uc029voj.2 uc029voj.3 
ENSMUST00000037875.6 Rrbp1 ENSMUST00000037875.6 ribosome binding protein 1, transcript variant 2 (from RefSeq NM_133626.2) A2AVJ8 ENSMUST00000037875.1 ENSMUST00000037875.2 ENSMUST00000037875.3 ENSMUST00000037875.4 ENSMUST00000037875.5 NM_133626 Q99PK5 Q99PK6 Q99PK7 Q99PK8 Q99PK9 Q99PL0 Q99PL1 Q99PL2 Q99PL3 Q99PL4 Q99PL5 Q9CS20 RRBP1_MOUSE uc008mqk.1 uc008mqk.2 uc008mqk.3 uc008mqk.4 Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. Endoplasmic reticulum membrane ; Single-pass type III membrane protein Event=Alternative splicing; Named isoforms=12; Comment=Additional isoforms seem to exist.; Name=3; IsoId=Q99PL5-1; Sequence=Displayed; Name=RRp61; Synonyms=p180; IsoId=Q99PL5-2; Sequence=VSP_003963, VSP_003964; Name=RRp47; IsoId=Q99PL5-3; Sequence=VSP_003959, VSP_003963, VSP_003964; Name=RRp41; IsoId=Q99PL5-4; Sequence=VSP_003961, VSP_003963, VSP_003964; Name=RRp16.8; IsoId=Q99PL5-5; Sequence=VSP_003954, VSP_003962, VSP_003963, VSP_003964; Name=RRp15a; IsoId=Q99PL5-6; Sequence=VSP_003958, VSP_003963, VSP_003964; Name=RRp15b; IsoId=Q99PL5-7; Sequence=VSP_003955, VSP_003963, VSP_003964; Name=RRp10; IsoId=Q99PL5-8; Sequence=VSP_003956, VSP_003963, VSP_003964; Name=RRp5.4; IsoId=Q99PL5-9; Sequence=VSP_003957, VSP_003963, VSP_003964; Name=RRp2; IsoId=Q99PL5-10; Sequence=VSP_003953, VSP_003963, VSP_003964; Name=RRp1.8; IsoId=Q99PL5-11; Sequence=VSP_003951, VSP_003963, VSP_003964; Name=RRp0; Synonyms=ES130; IsoId=Q99PL5-12; Sequence=VSP_003952, VSP_003963, VSP_003964; Widely expressed. protein binding endoplasmic reticulum endoplasmic reticulum membrane signal transduction protein transport membrane integral component of membrane integral component of endoplasmic reticulum membrane uc008mqk.1 uc008mqk.2 uc008mqk.3 uc008mqk.4 
ENSMUST00000037877.11 Tcfl5 ENSMUST00000037877.11 transcription factor-like 5 (basic helix-loop-helix), transcript variant 2 (from RefSeq NM_178254.4) ENSMUST00000037877.1 ENSMUST00000037877.10 ENSMUST00000037877.2 ENSMUST00000037877.3 ENSMUST00000037877.4 ENSMUST00000037877.5 ENSMUST00000037877.6 ENSMUST00000037877.7 ENSMUST00000037877.8 ENSMUST00000037877.9 NM_178254 Q32NY8 Q32NY8_MOUSE Tcfl5 uc008ojo.1 uc008ojo.2 uc008ojo.3 uc008ojo.4 uc008ojo.5 Nucleus negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding male germ cell nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated spermatogenesis regulation of cell proliferation regulation of cell differentiation protein dimerization activity uc008ojo.1 uc008ojo.2 uc008ojo.3 uc008ojo.4 uc008ojo.5 
ENSMUST00000037879.8 Heca ENSMUST00000037879.8 hdc homolog, cell cycle regulator (from RefSeq NM_001033432.4) ENSMUST00000037879.1 ENSMUST00000037879.2 ENSMUST00000037879.3 ENSMUST00000037879.4 ENSMUST00000037879.5 ENSMUST00000037879.6 ENSMUST00000037879.7 Heca NM_001033432 Q3V1N5 Q3V1N5_MOUSE uc007elw.1 uc007elw.2 uc007elw.3 molecular_function nucleus cytoplasm negative regulation of mitotic cell cycle uc007elw.1 uc007elw.2 uc007elw.3 
ENSMUST00000037882.8 Cd207 ENSMUST00000037882.8 CD207 antigen (from RefSeq NM_144943.3) CLC4K_MOUSE Clec4k ENSMUST00000037882.1 ENSMUST00000037882.2 ENSMUST00000037882.3 ENSMUST00000037882.4 ENSMUST00000037882.5 ENSMUST00000037882.6 ENSMUST00000037882.7 NM_144943 Q8R442 Q8VBX4 uc009cnw.1 uc009cnw.2 uc009cnw.3 uc009cnw.4 Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Homotrimer. Membrane; Single-pass type II membrane protein. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes. Expressed by Langerhans cells. Expressed in dendritic cells and by scattered cells in lymph nodes and spleen. Also detected in some non-lymphoid tissues such as lung, liver and heart. The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans. Name=Functional Glycomics Gateway - Glycan Binding; Note=Langerin; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_360"; integral component of plasma membrane membrane integral component of membrane carbohydrate binding defense response to virus uc009cnw.1 uc009cnw.2 uc009cnw.3 uc009cnw.4 
ENSMUST00000037900.9 Cpne7 ENSMUST00000037900.9 copine VII (from RefSeq NM_170684.2) CPNE7_MOUSE Cpne7 ENSMUST00000037900.1 ENSMUST00000037900.2 ENSMUST00000037900.3 ENSMUST00000037900.4 ENSMUST00000037900.5 ENSMUST00000037900.6 ENSMUST00000037900.7 ENSMUST00000037900.8 NM_170684 Q0VE82 uc009nuf.1 uc009nuf.2 uc009nuf.3 Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.288409.1, SRR1660811.104202.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Cytoplasm Nucleus Cell membrane Note=Translocates to the cell membrane in a calcium-dependent manner. The C2 domain 1 is not necessary for calcium-mediated translocation and association to the plasma membrane. The C2 domain 2 is necessary for calcium-mediated translocation and association to the plasma membrane. Belongs to the copine family. calcium-dependent phospholipid binding nucleus cytoplasm plasma membrane membrane cellular response to calcium ion uc009nuf.1 uc009nuf.2 uc009nuf.3 
ENSMUST00000037906.6 Tmem177 ENSMUST00000037906.6 transmembrane protein 177 (from RefSeq NM_175106.4) ENSMUST00000037906.1 ENSMUST00000037906.2 ENSMUST00000037906.3 ENSMUST00000037906.4 ENSMUST00000037906.5 NM_175106 Q8BPE4 TM177_MOUSE uc007cja.1 uc007cja.2 uc007cja.3 uc007cja.4 uc007cja.5 Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. Found in a complex with COX20, COA6, MT-CO2/COX2, COX18, SCO1 and SCO2. Interacts with COX20. Interacts with COX1, MT-CO2/COX2, SCO1 and SCO2 in a COX20-dependent manner. Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the TMEM177 family. molecular_function mitochondrion mitochondrial inner membrane biological_process membrane integral component of membrane integral component of mitochondrial inner membrane uc007cja.1 uc007cja.2 uc007cja.3 uc007cja.4 uc007cja.5 
ENSMUST00000037907.13 Rigi ENSMUST00000037907.13 RNA sensor RIG-I (from RefSeq NM_172689.3) A2AP28 Ddx58 ENSMUST00000037907.1 ENSMUST00000037907.10 ENSMUST00000037907.11 ENSMUST00000037907.12 ENSMUST00000037907.2 ENSMUST00000037907.3 ENSMUST00000037907.4 ENSMUST00000037907.5 ENSMUST00000037907.6 ENSMUST00000037907.7 ENSMUST00000037907.8 ENSMUST00000037907.9 NM_172689 Q6Q899 Q8C320 Q8C5I3 Q8C7T2 RIGI_MOUSE Rigi uc008shf.1 uc008shf.2 uc008shf.3 Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length- dependent manner through ubiquitination-dependent and -independent mechanisms. Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons. Ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Sendai virus (SeV), Rhabdoviridae and Flaviviridae. It also detects rotavirus and orthoreovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome. Detects dsRNA produced from non-self dsDNA by RNA polymerase III. May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Monomer; maintained as a monomer in an autoinhibited state. Upon binding of viral RNAs and conformational shift, homooligomerizes and forms filaments on these molecules. Interacts (via tandem CARD domain) with MAVS/IPS1 promoting its filamentation. Interacts with DHX58/LGP2, IKBKE, TBK1 and STING1. Interacts (via CARD domain) with TRIM25 (via SPRY domain). Interacts (double-stranded RNA-bound oligomeric form) with RNF135 (homodimer); involved in RNA length- dependent activation of the RIG-I signaling pathway. Interacts with CYLD. Interacts with NLRC5; blocks the interaction of MAVS/IPS1 to RIGI. Interacts with SRC. Interacts with DDX60. Interacts with ZC3HAV1 (via zinc-fingers) in an RNA-dependent manner. Interacts (via tandem CARD domain) with SEC14L1; the interaction is direct and impairs the interaction of RIGI with MAVS/IPS1. Interacts with VCP/p97; interaction is direct and allows the recruitment of RNF125 and subsequent ubiquitination and degradation. Interacts with NOP53; may regulate RIGI through USP15-mediated 'Lys-63'-linked deubiquitination (By similarity). Interacts with SIGLEC10, CBL and PTPN11; within a negative feedback loop leading to RIGI degradation (PubMed:23374343). Interacts with LRRC25. Interacts with ZCCHC3; leading to activation of RIGI. Interacts with RNF123 (By similarity). Interacts with UBE2D3 and UBE2N; E2 ubiquitin ligases involved in RNF135-mediated ubiquitination of RIGI and activation of the RIG-I signaling pathway (By similarity). Interacts with IFIT3 (By similarity). Interacts with DDX3X (By similarity). Interacts with RTN3 (By similarity). Interacts with ARL16; this interaction is GTP-dependent and induced upon viral infection; this interaction suppresses the RNA sensing activity of RIGI (By similarity). Interacts with DHX16; this interaction enhances RIGI- mediated antiviral response (By similarity). Interacts with Irgm1; promoting RIGI degradation (By similarity). Interacts with IFI6; this interaction inhibits RIGI activation (By similarity).Interacts with ECSIT; this interaction bridges RIGI to the MAVS complex at the mitochondrion (By similarity). Interacts with YWHAE; this interaction drives RIGI at the mitochondrion. Q6Q899; P22682: Cbl; NbExp=3; IntAct=EBI-6841237, EBI-640919; Q6Q899; Q80ZE3: Siglec10; NbExp=7; IntAct=EBI-6841237, EBI-6841023; Cytoplasm Cell projection, ruffle membrane Cytoplasm, cytoskeleton Cell junction, tight junction Note=Colocalized with TRIM25 at cytoplasmic perinuclear bodies. Associated with the actin cytoskeleton at membrane ruffles. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6Q899-1; Sequence=Displayed; Name=2; IsoId=Q6Q899-2; Sequence=VSP_016055, VSP_016060; Name=3; IsoId=Q6Q899-3; Sequence=VSP_016058, VSP_016059; Name=4; IsoId=Q6Q899-4; Sequence=VSP_016056, VSP_016057; By interferon (IFN). The RLR CTR domain controls homooligomerization and interaction with MAVS/IPS1. In the absence of viral infection, the protein is maintained as a monomer in an autoinhibited state with the CARD domains masked through intramolecular interactions with the RLR CTR domain. Upon binding to viral RNA and ubiquitination by RNF135, a conformational change releases the autoinhibition promoting further homooligomerization, interaction of the CARD domains with the adapter protein MAVS/IPS1 and activation of the downstream RIG-I signaling pathway. The helicase domain is responsible for dsRNA recognition. The 2 CARD domains are responsible for interaction with and signaling through MAVS/IPS1 and for association with the actin cytoskeleton. The second CARD domain is the primary site for 'Lys-63'-linked ubiquitination. Phosphorylated in resting cells and dephosphorylated in RNA virus- infected cells. Phosphorylation at Thr-771 results in inhibition of its activity while dephosphorylation at these sites results in its activation. ISGylated. Conjugated to ubiquitin-like protein ISG15 upon IFN- beta stimulation. ISGylation negatively regulates its function in antiviral signaling response. Sumoylated, probably by MUL1; inhibiting its polyubiquitination. Ubiquitinated. 'Lys-63' ubiquitination by RNF135, which occurs after RNA-binding and homodimerization, releases the autoinhibition of the CARD domains by the RLR CTR domain, an essential step in the activation of the RIG-I signaling pathway. Also ubiquitinated by TRIM4. Also undergoes 'Lys-48' ubiquitination by RNF125 that leads to proteasomal degradation. 'Lys-48' ubiquitination follows viral infection and is enhanced by 'Lys-63'-linked ubiquitination of the CARD domains that promotes interaction with VCP/p97 and subsequent recruitment of RNF125 (By similarity). Within a negative feedback loop involving SIGLEC10 and PTPN11, 'Lys-48' ubiquitination at Lys-813 by CBL also elicits the proteasomal degradation of RIGI (PubMed:23374343). Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'- linked ubiquitin chains. Also probably deubiquitinated by USP17L2/USP17 that cleaves 'Lys-48'- and 'Lys-63'-linked ubiquitin chains and positively regulates the receptor (By similarity). Ubiquitinated by TRIM40 via 'Lys-48'-linked ubiquitination; leading to proteasomal degradation (By similarity). Deubiquitinated by USP27X that cleaves 'Lys-63'-linked ubiquitin chains and inhibits the innate immune receptor activity (By similarity). Degraded via selective autophagy following interaction with Irgm1. Irgm1 promotes RIGI recruitment to autophagosome membranes, promoting its SQSTM1/p62-dependent autophagic degradation. Death between 12.5 dpc and 14 dpc due to liver apoptosis. Those who are born alive show growth retardation and die within 3 weeks. Belongs to the helicase family. RLR subfamily. nucleotide binding positive regulation of defense response to virus by host immune system process positive regulation of myeloid dendritic cell cytokine production DNA binding double-stranded DNA binding RNA binding RNA helicase activity double-stranded RNA binding single-stranded RNA binding helicase activity protein binding ATP binding cytoplasm cytosol cytoskeleton plasma membrane bicellular tight junction zinc ion binding detection of virus response to virus positive regulation of gene expression actin cytoskeleton membrane hydrolase activity cell junction regulation of cell migration ubiquitin protein ligase binding ruffle membrane positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of interferon-beta secretion RIG-I signaling pathway identical protein binding cell projection response to exogenous dsRNA innate immune response positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of sequence-specific DNA binding transcription factor activity defense response to virus positive regulation of response to cytokine stimulus cellular response to exogenous dsRNA positive regulation of interferon-alpha secretion positive regulation of tumor necrosis factor secretion positive regulation of interleukin-6 secretion uc008shf.1 uc008shf.2 uc008shf.3 
ENSMUST00000037912.12 Ssh2 ENSMUST00000037912.12 slingshot protein phosphatase 2, transcript variant 1 (from RefSeq NM_177710.4) B9EJ94 ENSMUST00000037912.1 ENSMUST00000037912.10 ENSMUST00000037912.11 ENSMUST00000037912.2 ENSMUST00000037912.3 ENSMUST00000037912.4 ENSMUST00000037912.5 ENSMUST00000037912.6 ENSMUST00000037912.7 ENSMUST00000037912.8 ENSMUST00000037912.9 Kiaa1725 NM_177710 Q3TDK8 Q3TYP8 Q3U2K3 Q5F268 Q5SW74 Q5SW75 Q69ZC3 Q76I78 SSH2_MOUSE Ssh2l uc007kgl.1 uc007kgl.2 uc007kgl.3 uc007kgl.4 uc007kgl.5 Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:14531860). Required for spermatogenesis (PubMed:36942942). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (PubMed:36942942). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Interacts with filamentous actin. Cytoplasm Cytoplasm, cytoskeleton Cell junction, focal adhesion Cytoplasmic vesicle, secretory vesicle, acrosome Note=Colocalizes with filamentous actin in the cytoplasm and the cell periphery. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5SW75-1; Sequence=Displayed; Name=2; IsoId=Q5SW75-2; Sequence=VSP_016326; Name=3; IsoId=Q5SW75-3; Sequence=VSP_016326, VSP_016328, VSP_016329; Name=4; IsoId=Q5SW75-4; Sequence=VSP_016327; Expressed in brain, heart, liver, skeletal muscle, testis and thymus. Also expressed at lower levels in kidney, small intestine and spleen (PubMed:14531860). Within testicular seminiferous tubules expressed in germ cells and spermatocytes, where it has a cytoplasmic localization, and round spermatids, where it concentrates in the acrosomal region next to the nucleus (PubMed:36942942). Expressed in the nervous system at 14.5 dpc (PubMed:14531860). Undetectable in testes at 7 days after birth (PubMed:36942942). Gradually increased expression between 14 and 35 days after birth followed by slightly decreased expression by 56 days after birth (at protein level) (PubMed:36942942). Complete male infertility but no effect on body weight or testis weight and size (PubMed:36942942). Impaired spermatogenesis devoid of spermatid elongation (arrested at stage II- III), resulting in accumulation of round spermatids with malformed acrosomal structures (PubMed:36942942). Spermatids and germ cells show increased levels of apoptosis via BCL2-caspase-3 pathway (PubMed:36942942). Actin cytoskeleton disorganization and actin filament aggregation in spermatids and germ cells, along with increased levels of cofilin phosphorylation (PubMed:36942942). Tyrosine phosphatase activity has not been demonstrated for this protein to date. Belongs to the protein-tyrosine phosphatase family. Sequence=BAE41593.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=CAI24907.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAI35940.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAI51882.1; Type=Erroneous gene model prediction; Evidence=; cell morphogenesis actin binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytoplasm cytoskeleton focal adhesion protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity actin cytoskeleton organization cell junction positive regulation of cell migration peptidyl-tyrosine dephosphorylation uc007kgl.1 uc007kgl.2 uc007kgl.3 uc007kgl.4 uc007kgl.5 
ENSMUST00000037913.9 Rmi2 ENSMUST00000037913.9 RecQ mediated genome instability 2 (from RefSeq NM_001162932.1) ENSMUST00000037913.1 ENSMUST00000037913.2 ENSMUST00000037913.3 ENSMUST00000037913.4 ENSMUST00000037913.5 ENSMUST00000037913.6 ENSMUST00000037913.7 ENSMUST00000037913.8 Gm929 NM_001162932 Q3UPE3 Q3V2Y5 RMI2_MOUSE uc007yek.1 uc007yek.2 uc007yek.3 uc007yek.4 Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM (By similarity). Nucleus Note=Colocalizes with BLM at nuclear DNA repair foci. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UPE3-1; Sequence=Displayed; Name=2; IsoId=Q3UPE3-2; Sequence=VSP_027288; Phosphorylated during mitosis. Belongs to the RMI2 family. molecular_function DNA binding nucleus cytosol DNA replication DNA repair nuclear speck regulation of sister chromatid segregation maintenance of rDNA negative regulation of double-strand break repair via homologous recombination uc007yek.1 uc007yek.2 uc007yek.3 uc007yek.4 
ENSMUST00000037915.9 Msl1 ENSMUST00000037915.9 male specific lethal 1, transcript variant 1 (from RefSeq NM_028722.3) A3KFP2 A3KFP4 ENSMUST00000037915.1 ENSMUST00000037915.2 ENSMUST00000037915.3 ENSMUST00000037915.4 ENSMUST00000037915.5 ENSMUST00000037915.6 ENSMUST00000037915.7 ENSMUST00000037915.8 MSL1_MOUSE Msl1l1 NM_028722 Q27QB3 Q3TTE5 Q6PDM1 Q80XS0 Q8BPN3 Q9CXF9 Q9D5C9 uc007lhj.1 uc007lhj.2 uc007lhj.3 uc007lhj.4 Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:24913909). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub) (By similarity). This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:21217699). Isoform 2, isoform 3, isoform 4 and isoform 5 can medite histone H4 acetylation at 'Lys- 16' (H4K16ac) (PubMed:24913909). Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3 (By similarity). Directly interacts with MSL2 via its coiled coil domain (By similarity). Directly interacts with NUPR1 (By similarity). Interacts with TP53BP1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity (By similarity). Forms a MSL heterotetrameric core with MSL2 (By similarity). Interacts with KAT8 and MSL3; both interactions are direct (PubMed:21217699, PubMed:17335777). Isoform 1 and isoform 3 interact with TTC4 (PubMed:17335777). Isoform 1 interacts with ECM2 and PIHD1 (PubMed:17335777). Nucleus [Isoform 1]: Nucleus Nucleus speckle [Isoform 2]: Nucleus Nucleus speckle [Isoform 3]: Nucleus Nucleus, nucleoplasm [Isoform 4]: Nucleus, nucleoplasm [Isoform 5]: Nucleus, nucleoplasm Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Hampin A ; IsoId=Q6PDM1-1; Sequence=Displayed; Name=2; Synonyms=Hampin B ; IsoId=Q6PDM1-2; Sequence=VSP_035241; Name=3; Synonyms=Hampin C ; IsoId=Q6PDM1-3; Sequence=VSP_035239, VSP_035240, VSP_035241; Name=4; Synonyms=Hampin D ; IsoId=Q6PDM1-4; Sequence=VSP_035242, VSP_035243; Name=5; Synonyms=Hampin E ; IsoId=Q6PDM1-5; Sequence=VSP_035239, VSP_035240, VSP_035242, VSP_035243; Name=6; IsoId=Q6PDM1-6; Sequence=VSP_035238, VSP_035242, VSP_035243; Isoform 3 and isoform 5 are testis-specific (PubMed:16119455). Isoform 1 and isoform 4 are ubiquitously expressed (PubMed:16119455). Isoform 2 is expressed at low levels in the testis and brain (PubMed:16119455). The coiled coil is formed by helices from two subunits in the MSL1 homodimer. Sumoylated with SUMO1. Belongs to the msl-1 family. Sequence=BAC35489.1; Type=Frameshift; Evidence=; chromatin binding protein binding nucleus nucleoplasm chromatin organization nuclear speck histone H4-K16 acetylation MSL complex uc007lhj.1 uc007lhj.2 uc007lhj.3 uc007lhj.4 
ENSMUST00000037918.12 Tmem33 ENSMUST00000037918.12 transmembrane protein 33, transcript variant 1 (from RefSeq NM_028975.4) Db83 ENSMUST00000037918.1 ENSMUST00000037918.10 ENSMUST00000037918.11 ENSMUST00000037918.2 ENSMUST00000037918.3 ENSMUST00000037918.4 ENSMUST00000037918.5 ENSMUST00000037918.6 ENSMUST00000037918.7 ENSMUST00000037918.8 ENSMUST00000037918.9 NM_028975 Q544Q3 Q9CR67 Q9D3M3 Q9DAV4 TMM33_MOUSE uc008xpq.1 uc008xpq.2 uc008xpq.3 Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (PubMed:31048699). Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling. Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (By similarity). Interacts with EIF2AK3 (By similarity). Interacts with RTN1, RTN2, RTN3, RTN4 and ARL6IP1 (By similarity). Interacts with RNF5. Interacts with RNF26 (By similarity). Interacts with PKD2 (PubMed:31048699). Endoplasmic reticulum membrane ; Multi-pass membrane protein Melanosome Nucleus envelope Note=Co-localizes with RTN4 at the ER sheets. Deletion mice show renal protection against acute kidney injury (AKI). Belongs to the PER33/POM33 family. protein binding nucleus nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane integral component of endoplasmic reticulum membrane response to endoplasmic reticulum stress melanosome regulation of endoplasmic reticulum tubular network organization positive regulation of IRE1-mediated unfolded protein response positive regulation of PERK-mediated unfolded protein response nuclear pore uc008xpq.1 uc008xpq.2 uc008xpq.3 
ENSMUST00000037923.5 Rbm24 ENSMUST00000037923.5 RNA binding motif protein 24 (from RefSeq NM_001081425.1) D3Z4I3 ENSMUST00000037923.1 ENSMUST00000037923.2 ENSMUST00000037923.3 ENSMUST00000037923.4 NM_001081425 RBM24_MOUSE Rbm24 uc007qhe.1 uc007qhe.2 uc007qhe.3 Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:25313962, PubMed:26844700). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:25313962, PubMed:26844700). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:25313962, PubMed:26844700). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (PubMed:25313962). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability. Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities. Involved in myogenic differentiation by regulating MYOG levels. Binds to multiple regions in the mRNA 3'-UTR of TP63, hence inducing its destabilization. Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence. Plays a role in the regulation of mRNA translation. Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation. Binds to a huge amount of mRNAs (By similarity). Required for embryonic heart development, sarcomer and M- band formation in striated muscles (PubMed:25313962, PubMed:29358667). Together with RBM20, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). Interacts with EIF4E; this interaction prevents EIF4E from binding to p53/TP53 mRNA and inhibits the assembly of translation initiation complex. Nucleus Cytoplasm Expressed strongly in heart and skeletal muscles (PubMed:25313962). Weakly expressed in intestine, aorta, liver, lung, kidney, uterus and bladder (PubMed:25313962). Expressed in embryonic heart at 11.5 and 13.5 dpc (PubMed:25313962). Expressed in MyoD-expressing myoblasts at 11.5 dpc (at protein level) (PubMed:25217815). Expressed in the early cardiac mesoderm at 7 dpc (PubMed:19658189). Expressed in the cardiac crescent at 8 dpc (PubMed:19658189). Expressed in the developing heart and somites from 9.5 to 12.5 dpc (PubMed:19658189, PubMed:25313962, PubMed:25217815). Expressed in the lens, otic vesicle, heart and weakly in the mesodermal core of the first and second branchial arches at 10.5 dpc (PubMed:25217815). Expressed in all appendicular muscle masses at the forelimb and hindlimb levels and in developing head muscles at 11.5 dpc (PubMed:25217815). Expressed in appendicular muscle masses, diaphragm muscle and developing head muscles at 12.5 dpc (PubMed:25217815). Up-regulated during embryonic stem cell (ESC) differentiation into cardiomyocytes (PubMed:26990106). Down-regulated by microRNA-222 (miR-222) in skeletal muscle cells, leading in inhibition of muscle-specific pre-mRNA alternative splicing events and myoblast fusion (PubMed:26844700). The RRM domain is necessary for mRNA stability and mRNA translation regulation. Mice die in utero between embryonic days 12.5 and 14.5 (PubMed:25313962, PubMed:29358667). Show multiple cardiac malformations, including defective endocardial cushion morphogenesis, ventricular septum defects, reduced trabeculation and compaction and dilated atria (PubMed:25313962, PubMed:29358667). Display loss of sarcomeres in cardiomyocytes (PubMed:25313962). Show aberrant pre-mRNA alternative splicing of key genes necessary for sarcomere formation and cardiogenesis (PubMed:25313962). regulation of alternative mRNA splicing, via spliceosome endocardial cushion development nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding nucleus nucleoplasm cytoplasm cytosol mRNA processing regulation of translation cellular response to DNA damage stimulus RNA splicing regulation of myotube differentiation positive regulation of myotube differentiation cell differentiation mRNA 3'-UTR AU-rich region binding regulation of mRNA stability positive regulation of myoblast differentiation mRNA stabilization mRNA destabilization 3'-UTR-mediated mRNA destabilization 3'-UTR-mediated mRNA stabilization pre-mRNA intronic binding positive regulation of skeletal muscle fiber differentiation mRNA CDS binding sequence-specific mRNA binding ribonucleoprotein complex positive regulation of stem cell differentiation negative regulation of cytoplasmic translation uc007qhe.1 uc007qhe.2 uc007qhe.3 
ENSMUST00000037941.10 Cd81 ENSMUST00000037941.10 CD81 antigen (from RefSeq NM_133655.2) CD81_MOUSE Cd81 ENSMUST00000037941.1 ENSMUST00000037941.2 ENSMUST00000037941.3 ENSMUST00000037941.4 ENSMUST00000037941.5 ENSMUST00000037941.6 ENSMUST00000037941.7 ENSMUST00000037941.8 ENSMUST00000037941.9 NM_133655 P35762 Q91V78 Tapa1 uc009kou.1 uc009kou.2 uc009kou.3 uc009kou.4 Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells (PubMed:23499492). Upon initial encounter with a microbial pathogen, enables the assembly of CD19-CR2 and B cell receptor complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and humoral immune response (By similarity). In T cells, associates with CD4 or CD8 coreceptors and defines the maturation state of antigen-induced synapses with B cells (By similarity). Facilitates localization of CD3 in these immune synapses, required for costimulation and sustained activation of T cells, preferentially triggering T helper type 2 immune response (PubMed:11046035). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. In myoblasts, associates with another tetraspanin CD9 in complex with PTGFRN and inhibits myotube fusion during muscle regeneration (PubMed:23575678). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption. Positively regulates sperm-egg fusion and may be involved in the acrosome reaction (PubMed:16380109, PubMed:17290409). Regulates protein trafficking in intracellular compartments. In T cells, associates with dNTPase SAMHD1 and defines its subcellular location, enabling its degradation by the proteasome and thereby controlling intracellular dNTP levels (By similarity). Also regulates integrin-dependent migration of macrophages, particularly relevant for inflammatory response in the lung (PubMed:18662991). (Microbial infection) Specifically required for Plasmodium yoelii infectivity of hepatocytes, controlling sporozoite entry in hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms. Homodimer (By similarity). Part of a complex composed of CD19, CR2/CD21, CD81 and IFITM1/CD225 in the membrane of mature B cells. Interacts (via the second extracellular domain) with CD19; this interaction is initiated early during biosynthesis in the ER and enables trafficking of only properly folded CD19 (By similarity). Part of a complex that includes MHC class II/HLA-DR molecules and IFITM1. Interacts with IFITM1 (By similarity). Interacts with IFITM2 and IFITM3 (PubMed:16395393). Part of integrin-tetraspanin complex composed of CD9, CD81, beta-1 and beta-2 integrins in the membrane of monocyte/macrophages (By similarity). Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (By similarity). Interacts with CD247/CD3 zeta, ICAM1 and CD9 at the immune synapse on T cell membrane (By similarity). Part of a GPCR-tetraspanin complex consisting at least of ADGRG1, CD81, possibly CD9, and GNA11 in which CD81 enhances the association of ADGRG1 with GNA11 (By similarity). Part of a complex composed of CD9, CD81, PTGFRN and IGSF8 (PubMed:23575678). Interacts directly with IGSF8 (PubMed:11673522). Interacts with CD53 and SCIMP (By similarity). Interacts with SAMHD1 (via its C-terminus) (By similarity). Interacts with glypican GPC3 and with the transcriptional repressor HHEX; binding to GPC3 decreases the availability of free CD81 for binding to HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (PubMed:23665349). Interacts with CLDN1 (By similarity). Interacts with CLDN6 and CLDN9 (By similarity). Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Note=Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. Expressed in oocytes (at protein level) (PubMed:16380109, PubMed:17290409, PubMed:23213457). Highly expressed in granulosa cells (PubMed:16380109). Expressed in skeletal muscle mainly in endothelial cells of endomysial capillaries, in satellite cells and myoblasts (at protein level) (PubMed:23575678). Expressed in hepatocytes (at protein level) (PubMed:12483205). Up-regulated in response to notexin-induced acute myoinjury. Binds cholesterol in a cavity lined by the transmembrane spans. Not glycosylated. Likely constitutively palmitoylated at low levels. Protein palmitoylation is up-regulated upon coligation of BCR and CD9-C2R-CD81 complexes in lipid rafts. Knockout mice exhibit reduced female fertitily and impaired egg-sperm fusion (PubMed:16380109, PubMed:17290409). In response to notexin-induced acute myoinjury, mutant mice display abnormal muscle regeneration characterized by typical giant distrophic myofibres (PubMed:23575678). Mutant mice show reduced allergen-induced lung inflammation, eosinophilia and mucin production (PubMed:11046035). These mice spontaneously develop multinucleated giant cells (MGCs) and show enhanced osteoclastogenesis when compared to wild-type littermates (PubMed:12796480). CD81 and CD9 double knockout mice develop pulmonary emphysema, reminiscent of chronic obstructive pulmonary disease in human (PubMed:18662991). (Microbial infection) Mutant mice are refractory to Plasmodium yoelii sporozoite infection. Belongs to the tetraspanin (TM4SF) family. activation of MAPK activity virus receptor activity immunological synapse formation immunological synapse adaptive immune response immune system process humoral immune response mediated by circulating immunoglobulin positive regulation of inflammatory response to antigenic stimulus integrin binding protein binding plasma membrane integral component of plasma membrane protein localization positive regulation of cell proliferation lipid binding myoblast fusion involved in skeletal muscle regeneration cholesterol binding membrane integral component of membrane basolateral plasma membrane apical plasma membrane positive regulation of cell growth positive regulation of B cell proliferation receptor internalization regulation of protein stability vesicle macrophage fusion CD4-positive, alpha-beta T cell costimulation regulation of cell proliferation MHC class II protein binding positive regulation of 1-phosphatidylinositol 4-kinase activity positive regulation of transcription from RNA polymerase II promoter viral entry into host cell positive regulation of peptidyl-tyrosine phosphorylation positive regulation of B cell receptor signaling pathway positive regulation of T cell receptor signaling pathway positive regulation of B cell activation protein localization to lysosome extracellular exosome positive regulation of protein exit from endoplasmic reticulum cellular response to low-density lipoprotein particle stimulus protein localization to plasma membrane osteoclast fusion tetraspanin-enriched microdomain positive regulation of receptor clustering positive regulation of protein catabolic process in the vacuole regulation of macrophage migration positive regulation of adaptive immune memory response transferrin receptor binding regulation of cell motility positive regulation of T-helper 2 cell cytokine production positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell uc009kou.1 uc009kou.2 uc009kou.3 uc009kou.4 
ENSMUST00000037958.14 Arhgap29 ENSMUST00000037958.14 Rho GTPase activating protein 29, transcript variant 1 (from RefSeq NM_172525.3) ENSMUST00000037958.1 ENSMUST00000037958.10 ENSMUST00000037958.11 ENSMUST00000037958.12 ENSMUST00000037958.13 ENSMUST00000037958.2 ENSMUST00000037958.3 ENSMUST00000037958.4 ENSMUST00000037958.5 ENSMUST00000037958.6 ENSMUST00000037958.7 ENSMUST00000037958.8 ENSMUST00000037958.9 NM_172525 Q3V135 Q7TMW2 Q8BLJ2 Q8BLR8 Q8CGF1 RHG29_MOUSE uc008reh.1 uc008reh.2 uc008reh.3 uc008reh.4 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. Interacts with PTPN13/PTPL1. Interacts with RAP2A via its coiled coil domain (By similarity). Interacts with RASIP1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CGF1-1; Sequence=Displayed; Name=2; IsoId=Q8CGF1-2; Sequence=VSP_031060; In embryos, present in the endothelial cells of the paired aortae during vasculogenesis (at protein level). GTPase activator activity protein binding cytoplasm signal transduction PDZ domain binding macromolecular complex intracellular signal transduction positive regulation of GTPase activity metal ion binding uc008reh.1 uc008reh.2 uc008reh.3 uc008reh.4 
ENSMUST00000037964.7 Txlnb ENSMUST00000037964.7 taxilin beta (from RefSeq NM_138628.3) B2RU93 ENSMUST00000037964.1 ENSMUST00000037964.2 ENSMUST00000037964.3 ENSMUST00000037964.4 ENSMUST00000037964.5 ENSMUST00000037964.6 Mdp77 NM_138628 Q3UVB8 Q8BUK2 Q8VBT1 TXLNB_MOUSE uc007elv.1 uc007elv.2 uc007elv.3 Promotes motor nerve regeneration. May be involved in intracellular vesicle traffic (By similarity). Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Has a preference for STX1A (By similarity). Specifically expressed in skeletal muscle. Belongs to the taxilin family. molecular_function cytoplasm biological_process syntaxin binding uc007elv.1 uc007elv.2 uc007elv.3 
ENSMUST00000037967.6 Slc10a3 ENSMUST00000037967.6 solute carrier family 10 (sodium/bile acid cotransporter family), member 3, transcript variant 1 (from RefSeq NM_145406.2) ENSMUST00000037967.1 ENSMUST00000037967.2 ENSMUST00000037967.3 ENSMUST00000037967.4 ENSMUST00000037967.5 NM_145406 P21129 P3 P3_MOUSE Q8QZR2 uc009tou.1 uc009tou.2 uc009tou.3 uc009tou.4 The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions. Membrane ; Multi-pass membrane protein Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. bile acid:sodium symporter activity response to organic substance symporter activity bile acid and bile salt transport membrane integral component of membrane response to retinoic acid transmembrane transport uc009tou.1 uc009tou.2 uc009tou.3 uc009tou.4 
ENSMUST00000037968.10 Uvrag ENSMUST00000037968.10 UV radiation resistance associated gene (from RefSeq NM_178635.3) ENSMUST00000037968.1 ENSMUST00000037968.2 ENSMUST00000037968.3 ENSMUST00000037968.4 ENSMUST00000037968.5 ENSMUST00000037968.6 ENSMUST00000037968.7 ENSMUST00000037968.8 ENSMUST00000037968.9 NM_178635 Q8BVI8 Q8C0K8 Q8K245 UVRAG_MOUSE Uvrag1 uc009ikz.1 uc009ikz.2 uc009ikz.3 uc009ikz.4 Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3- phosphate (PtdIns(3)P). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2. Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events. Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion. In case of negative- strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8- specific fusogenic SNARE complex assembly. Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ). Required for centrosome stability and proper chromosome segregation. Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex II (PI3KC3-C2) in which the core composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 is associated with UVRAG; in the complex interacts directly with BECN1 (By similarity). PI3KC3-C2 can associate with further regulatory subunits such as RUBCN and probably SH3GLB1/Bif-1 (By similarity). Interacts with SH3GLB1; UVRAG bridges the interaction to BECN1 indicative for an association with the PI3K complex PI3KC3-C2 (By similarity). Interacts with RINT1 (By similarity). Associates with the NRZ complex under basal conditions and dissociates from it under autophagy conditions to associate with the PI3K complex; these complex associations seem to be mutually exclusive (By similarity). Interacts with VPS16; VPS11; VPS18; VPS33 (VPS33A or VPS33B) and VPS39; indicative for an association with a class C Vps tethering complex (possibly the HOPS complex) (By similarity). Interacts with RAB7A; RAB7A competes with UVRAG for RUBCN binding (By similarity). Interacts with STX7, VTI1B, STX8 (By similarity). Interacts with PRKDC, XRCC6 and XRCC5; indicative for an association with the DNA-dependent protein kinase complex DNA-PK (By similarity). Interacts with CEP63 (By similarity). Directly interacts with FEZ1 and SCOC; the interaction with SCOC is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1 (By similarity). Interacts with BECN1P1/BECN2 (By similarity). Interacts with SLAMF1 (PubMed:22493499). Interacts with RUBCNL/PACER; promoting targeting of UVRAG to autophagosome (By similarity). Interacts with WNK1 (By similarity). Late endosome Lysosome Cytoplasmic vesicle, autophagosome Early endosome Endoplasmic reticulum Midbody Chromosome, centromere Note=Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial. Recruited to autophagosome following interaction with RUBCNL/PACER. Phosphorylated at Ser-497 by MTOR under basal conditions; increases the interaction with RUBCN implicated in inhibitory effect of RUBCN on PI3KC3 and decreases interaction with RAB7A, and VPS16 and VPS39 (indicative for a class C Vps complex, possibly the HOPS complex) (By similarity). SNARE binding autophagosome membrane chromosome, centromeric region protein binding chromosome lysosome endosome early endosome late endosome autophagosome endoplasmic reticulum centrosome DNA repair retrograde vesicle-mediated transport, Golgi to ER autophagy cellular response to DNA damage stimulus spindle organization chromosome segregation centrosome cycle SH3 domain binding midbody cytoplasmic vesicle regulation of cytokinesis receptor catabolic process macromolecular complex SNARE complex assembly phagocytic vesicle viral entry into host cell maintenance of Golgi location DNA-dependent protein kinase complex regulation of protein serine/threonine kinase activity autophagosome maturation double-strand break repair via classical nonhomologous end joining uc009ikz.1 uc009ikz.2 uc009ikz.3 uc009ikz.4 
ENSMUST00000037983.6 Ensa ENSMUST00000037983.6 endosulfine alpha, transcript variant 2 (from RefSeq NM_001026212.1) ENSA_MOUSE ENSMUST00000037983.1 ENSMUST00000037983.2 ENSMUST00000037983.3 ENSMUST00000037983.4 ENSMUST00000037983.5 NM_001026212 P60840 Q5D069 Q6PBG4 Q9CQZ9 Q9Z0G1 uc008qkj.1 uc008qkj.2 uc008qkj.3 Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity). Interacts (when phosphorylated at Ser-67) with PPP2R2D. Interacts with ABCC8. Interacts with SNCA; interaction is disrupted when phosphorylated at Ser-109 (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha; IsoId=P60840-1, Q9Z0G1-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=P60840-2, Q9Z0G1-2; Sequence=VSP_001444; Name=3; IsoId=P60840-3, Q9Z0G1-3; Sequence=VSP_037068, VSP_037069; Present in striatum (at protein level). Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA (By similarity). [Isoform 3]: May be due to an intron retention. Belongs to the endosulfine family. G2/M transition of mitotic cell cycle mitotic cell cycle protein phosphatase inhibitor activity receptor binding cytoplasm cell cycle response to glucose phosphatase inhibitor activity potassium channel inhibitor activity protein phosphatase regulator activity negative regulation of phosphoprotein phosphatase activity negative regulation of protein dephosphorylation negative regulation of catalytic activity regulation of phosphoprotein phosphatase activity regulation of insulin secretion cell division protein phosphatase 2A binding uc008qkj.1 uc008qkj.2 uc008qkj.3 
ENSMUST00000037991.12 Mical2 ENSMUST00000037991.12 microtubule associated monooxygenase, calponin and LIM domain containing 2, transcript variant A (from RefSeq NM_001193305.1) B1B545 ENSMUST00000037991.1 ENSMUST00000037991.10 ENSMUST00000037991.11 ENSMUST00000037991.2 ENSMUST00000037991.3 ENSMUST00000037991.4 ENSMUST00000037991.5 ENSMUST00000037991.6 ENSMUST00000037991.7 ENSMUST00000037991.8 ENSMUST00000037991.9 F6ZD54 F8WJF1 Kiaa0750 MICA2_MOUSE Mical2 Micalcl NM_001193305 Q14DP1 Q3TR48 Q3UPU6 Q5DU17 Q8BML1 Q8CID1 Q9D5U9 uc291unr.1 uc291unr.2 Methionine monooxygenase that promotes depolymerization of F- actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:23911929, PubMed:23927065). Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A- dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (By similarity). Reaction=H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl- (R)-S-oxide-[F-actin] + NADP(+); Xref=Rhea:RHEA:51308, Rhea:RHEA- COMP:12953, Rhea:RHEA-COMP:12956, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16044, ChEBI:CHEBI:45764, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.225; Evidence= Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Interacts with PLXNA4 (PubMed:12110185). Interacts with RAB1B (By similarity). Interacts with MAPK1/ERK2 (PubMed:18241670, PubMed:18590835). Interacts with RAB1B, RAB35, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B and RAB35 is of low affinity compared to other Rab proteins; binding to RAB1B and RAB35 is of low affinity compared to other Rab proteins; at least in case of RAB8A may bind 2 molecules of RAB8A simultaneously through a high and a low affinity binding site, respectively (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=7; Name=4; IsoId=Q8BML1-4; Sequence=Displayed; Name=1; IsoId=Q8BML1-1; Sequence=VSP_061301, VSP_061305, VSP_061309; Name=2; IsoId=Q8BML1-2; Sequence=VSP_061302, VSP_061306, VSP_061307; Name=3; IsoId=Q8BML1-3; Sequence=VSP_061301, VSP_061303, VSP_061304; Name=5; Synonyms=Ebitein1 ; IsoId=Q8BML1-5; Sequence=VSP_061310, VSP_061311, VSP_061314; Name=6; IsoId=Q8BML1-6; Sequence=VSP_061300, VSP_061308, VSP_061310, VSP_061311, VSP_061312, VSP_061313; Name=7; IsoId=Q8BML1-7; Sequence=VSP_061311; Expressed only in testis (at protein level). During spermatogenesis, first expressed after meiosis, gradually increases to a maximum at Oakberg's stage 9 and then decreases until it is undetectable when spermatozoa begin to generate flagella (at protein level). The C-terminal RAB-binding domain (RBD)(1796-1945), also described as bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms). Belongs to the Mical family. Sequence=BAB29617.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD90416.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAG12802.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; heart looping actin binding monooxygenase activity nucleus microtubule organizing center cytoskeleton organization heart development positive regulation of transcription via serum response element binding NAD(P)H oxidase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen sulfur oxidation actin cytoskeleton organization actin filament depolymerization filamentous actin NADPH:sulfur oxidoreductase activity metal ion binding oxidation-reduction process FAD binding uc291unr.1 uc291unr.2 
ENSMUST00000037992.16 Ssh3 ENSMUST00000037992.16 slingshot protein phosphatase 3, transcript variant 1 (from RefSeq NM_198113.3) ENSMUST00000037992.1 ENSMUST00000037992.10 ENSMUST00000037992.11 ENSMUST00000037992.12 ENSMUST00000037992.13 ENSMUST00000037992.14 ENSMUST00000037992.15 ENSMUST00000037992.2 ENSMUST00000037992.3 ENSMUST00000037992.4 ENSMUST00000037992.5 ENSMUST00000037992.6 ENSMUST00000037992.7 ENSMUST00000037992.8 ENSMUST00000037992.9 NM_198113 Q3UDX0 Q8K330 SSH3_MOUSE Ssh3l uc008fzo.1 uc008fzo.2 uc008fzo.3 uc008fzo.4 uc008fzo.5 Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Does not bind to, or colocalize with, filamentous actin. Cytoplasm, cytoskeleton Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K330-1; Sequence=Displayed; Name=2; IsoId=Q8K330-2; Sequence=VSP_016337; Expressed in brain, small intestine and testis. Also expressed at lower levels in heart, kidney, liver, spleen and thymus. Expressed in the nervous system and epithelial tissues of the trachea at 14.5 dpc. Tyrosine phosphatase activity has not been demonstrated for this protein to date. Belongs to the protein-tyrosine phosphatase family. cell morphogenesis actin binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm cytoskeleton protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc008fzo.1 uc008fzo.2 uc008fzo.3 uc008fzo.4 uc008fzo.5 
ENSMUST00000037994.8 Slfn1 ENSMUST00000037994.8 schlafen 1 (from RefSeq NM_011407.2) ENSMUST00000037994.1 ENSMUST00000037994.2 ENSMUST00000037994.3 ENSMUST00000037994.4 ENSMUST00000037994.5 ENSMUST00000037994.6 ENSMUST00000037994.7 NM_011407 Q9Z0I7 SLFN1_MOUSE Slfn1 uc007koi.1 uc007koi.2 uc007koi.3 Protein expressed in resting T-cells, which is required for maintaining T-cells in the quiescent state (PubMed:9846487, PubMed:15946944, PubMed:18373498). Acts by promoting cell-cycle arrest of T-cells through inhibiting the expression of cyclin-D1 (CCND1) (PubMed:15946944). Interacts with DNAJB6; promoting nuclear translocation and ability to promote cell-cycle arrest. Cytoplasm Nucleus Note=Translocates into the nucleus following interaction with DNAJB6. Mainly expressed in the thymus, lymph node and spleen (PubMed:9846487). Specifically expressed in T-lineage cells, but not in B-cells (PubMed:9846487). Strongly up-regulated during the differentiation from CD4(+)CD8(+) double-positive (DP) to CD4(+) or CD8(+) single-positive (SP) thymocytes (PubMed:9846487). Highly expressed in quiescent single-positive thymocytes and T-cells (PubMed:9846487). The expression substantially decreases after TCR (T- cell receptor)-mediated activation (PubMed:9846487). No visible phenotype. Belongs to the Schlafen family. negative regulation of transcription from RNA polymerase II promoter negative regulation of protein phosphorylation protein binding nucleus cytoplasm cell cycle arrest negative regulation of cell proliferation negative regulation of T cell proliferation negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter negative regulation of G1/S transition of mitotic cell cycle uc007koi.1 uc007koi.2 uc007koi.3 
ENSMUST00000037998.6 Tram2 ENSMUST00000037998.6 translocating chain-associating membrane protein 2 (from RefSeq NM_177409.3) ENSMUST00000037998.1 ENSMUST00000037998.2 ENSMUST00000037998.3 ENSMUST00000037998.4 ENSMUST00000037998.5 NM_177409 Q924Z5 TRAM2_MOUSE uc007alg.1 uc007alg.2 uc007alg.3 uc007alg.4 Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT). Interacts with COL1A1 (By similarity). Interacts with SERCA2B. Membrane ; Multi-pass membrane protein Belongs to the TRAM family. protein binding rough endoplasmic reticulum SRP-dependent cotranslational protein targeting to membrane, translocation protein transport membrane integral component of membrane collagen biosynthetic process protein insertion into ER membrane uc007alg.1 uc007alg.2 uc007alg.3 uc007alg.4 
ENSMUST00000038004.3 Krt25 ENSMUST00000038004.3 keratin 25 (from RefSeq NM_133730.2) ENSMUST00000038004.1 ENSMUST00000038004.2 K1C25_MOUSE Krt25 NM_133730 Q8VCW2 uc007lin.1 uc007lin.2 uc007lin.3 Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (PubMed:14996088, PubMed:17920809). Plays a role in the cytoskeleton organization (By similarity). Heterodimer of a type I and a type II keratin (PubMed:14996088). Heterodimer with type II keratin KRT5 leading to the formation of keratin intermediate filament (KIF) network. Interacts with KRT6A to form filaments (By similarity). Cytoplasm There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. structural molecule activity protein binding cytoplasm intermediate filament cytoskeleton organization aging hair follicle morphogenesis hair cycle intermediate filament organization protein heterodimerization activity uc007lin.1 uc007lin.2 uc007lin.3 
ENSMUST00000038006.8 Acmsd ENSMUST00000038006.8 amino carboxymuconate semialdehyde decarboxylase (from RefSeq NM_001033041.3) ACMSD_MOUSE B9EI97 ENSMUST00000038006.1 ENSMUST00000038006.2 ENSMUST00000038006.3 ENSMUST00000038006.4 ENSMUST00000038006.5 ENSMUST00000038006.6 ENSMUST00000038006.7 NM_001033041 Q3UNW3 Q8R519 uc007ckv.1 uc007ckv.2 uc007ckv.3 Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. Reaction=2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2- aminomuconate 6-semialdehyde + CO2; Xref=Rhea:RHEA:16557, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:77634, ChEBI:CHEBI:77803; EC=4.1.1.45; Secondary metabolite metabolism; quinolate metabolism. Monomer. Highest expression in kidney with lower levels in liver and brain. By streptozocin-induced diabetes. Repressed by low protein diet. Belongs to the metallo-dependent hydrolases superfamily. ACMSD family. aminocarboxymuconate-semialdehyde decarboxylase activity cytoplasm cytosol tryptophan catabolic process aging zinc ion binding hydrolase activity lyase activity carboxy-lyase activity metal ion binding quinolinate metabolic process protein oligomerization negative regulation of quinolinate biosynthetic process uc007ckv.1 uc007ckv.2 uc007ckv.3 
ENSMUST00000038010.5 Glt6d1 ENSMUST00000038010.5 glycosyltransferase 6 domain containing 1, transcript variant 5 (from RefSeq NR_184808.1) ENSMUST00000038010.1 ENSMUST00000038010.2 ENSMUST00000038010.3 ENSMUST00000038010.4 GL6D1_MOUSE NR_184808 Q2NKH9 uc008itl.1 uc008itl.2 uc008itl.3 Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mn(2+) ion per subunit. ; Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 6 family. Golgi apparatus carbohydrate metabolic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups lipid glycosylation vesicle uc008itl.1 uc008itl.2 uc008itl.3 
ENSMUST00000038014.11 Dnajc16 ENSMUST00000038014.11 DnaJ heat shock protein family (Hsp40) member C16 (from RefSeq NM_172338.2) DJC16_MOUSE ENSMUST00000038014.1 ENSMUST00000038014.10 ENSMUST00000038014.2 ENSMUST00000038014.3 ENSMUST00000038014.4 ENSMUST00000038014.5 ENSMUST00000038014.6 ENSMUST00000038014.7 ENSMUST00000038014.8 ENSMUST00000038014.9 Erdj8 Kiaa0962 NM_172338 Q80TN4 Q811G1 Q8BHI2 uc008vpf.1 uc008vpf.2 uc008vpf.3 Plays an important role in regulating the size of autophagosomes during the formation process. Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Sequence=AAH46424.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC65689.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cell biological_process membrane integral component of membrane cell redox homeostasis uc008vpf.1 uc008vpf.2 uc008vpf.3 
ENSMUST00000038027.6 Gpi1 ENSMUST00000038027.6 glucose-6-phosphate isomerase 1 (from RefSeq NM_008155.4) ENSMUST00000038027.1 ENSMUST00000038027.2 ENSMUST00000038027.3 ENSMUST00000038027.4 ENSMUST00000038027.5 G6PI_MOUSE Gpi Gpi1 NM_008155 O89062 P06745 Q3TEE7 Q3TW50 Q3UUX1 Q3UY84 Q3UZJ1 Q5RJI3 Q8C675 Q9JM07 uc009gix.1 uc009gix.2 uc009gix.3 uc009gix.4 uc009gix.5 This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Aug 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK031081.1, BC086640.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## multifunctional gene product(s) :: PMID: 3352745, 8674049 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:7277315, PubMed:2344351, PubMed:8417789). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (By similarity). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:3764429, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:3352745). Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate; Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225; EC=5.3.1.9; Evidence= Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 2/4. Homodimer in the catalytically active form, monomer in the secreted form. P06745; Q2EMV9: Parp14; NbExp=4; IntAct=EBI-1534927, EBI-1534943; Cytoplasm Secreted ISGylated. Embryonic lethality caused by impaired gastrulation (PubMed:8922529). During early development, the egg cylinder fails to be divided into the three cavities, suggesting a deficiency in extraembryonic mesoderm formation resulting in the failure to form the amnion or chorionic mesoderm (PubMed:8922529). Belongs to the GPI family. Sequence=BAC36335.1; Type=Erroneous initiation; Evidence=; in utero embryonic development mesoderm formation glucose-6-phosphate isomerase activity cytokine activity protein binding extracellular region extracellular space nucleoplasm cytoplasm cytosol plasma membrane carbohydrate metabolic process gluconeogenesis glycolytic process signal transduction learning or memory growth factor activity positive regulation of endothelial cell migration isomerase activity intramolecular transferase activity methylglyoxal biosynthetic process ubiquitin protein ligase binding response to estradiol response to progesterone response to testosterone erythrocyte homeostasis response to immobilization stress response to muscle stretch glucose homeostasis neuron projection negative regulation of cysteine-type endopeptidase activity involved in apoptotic process myelin sheath response to morphine negative regulation of neuron apoptotic process aldehyde catabolic process response to cadmium ion monosaccharide binding positive regulation of immunoglobulin secretion glucose 6-phosphate metabolic process ciliary membrane glycolytic process through glucose-6-phosphate canonical glycolysis uc009gix.1 uc009gix.2 uc009gix.3 uc009gix.4 uc009gix.5 
ENSMUST00000038032.7 5033430I15Rik ENSMUST00000038032.7 5033430I15Rik (from geneSymbol) AK017206 ENSMUST00000038032.1 ENSMUST00000038032.2 ENSMUST00000038032.3 ENSMUST00000038032.4 ENSMUST00000038032.5 ENSMUST00000038032.6 uc288mnq.1 uc288mnq.2 uc288mnq.3 uc288mnq.4 uc288mnq.1 uc288mnq.2 uc288mnq.3 uc288mnq.4 
ENSMUST00000038038.8 Slfn2 ENSMUST00000038038.8 schlafen 2 (from RefSeq NM_011408.1) ENSMUST00000038038.1 ENSMUST00000038038.2 ENSMUST00000038038.3 ENSMUST00000038038.4 ENSMUST00000038038.5 ENSMUST00000038038.6 ENSMUST00000038038.7 NM_011408 Q9Z0I6 SLFN2_MOUSE Slfn2 uc007kog.1 uc007kog.2 tRNA-binding protein involved in T-cell mediated immunity (PubMed:33986151). Plays a key role during the metabolic reprograming phase of activated T-cell, when T-cells produce reactive oxygen species (ROS): acts by binding tRNAs and protecting them from cleavage by the oxidative stress-activated ribonuclease angiogenin (ANG) (PubMed:33986151). Also required for T-cell quiescence maintenance (PubMed:20190759). Cytoplasm Mainly expressed in the thymus, lymph node and spleen. Upon interferon-alpha (IFN-alpha) treatment. Conditional deletion in T-cells leads to impaired T cell-mediated immunity (PubMed:33986151). T-cell show an accumulation of tRNA fragments, which inhibit translation and promote stress-granule formation (PubMed:33986151). Belongs to the Schlafen family. negative regulation of cell proliferation response to bacterium uc007kog.1 uc007kog.2 
ENSMUST00000038039.3 Tdp2 ENSMUST00000038039.3 tyrosyl-DNA phosphodiesterase 2 (from RefSeq NM_019551.2) A2RTH9 ENSMUST00000038039.1 ENSMUST00000038039.2 NM_019551 Q9JJX7 TYDP2_MOUSE Ttrap uc007pwl.1 uc007pwl.2 uc007pwl.3 uc007pwl.4 DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'- phosphate termini that are ready for ligation (PubMed:23104055, PubMed:24808172, PubMed:27099339, PubMed:27060144). Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2 (PubMed:22740648). Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single- stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6- TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stress (By similarity). Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 magnesium or manganese ion per subunit. Interacts with TRAF2, TRAF3, TRAF5, TRAF6, TNFRSF8/CD30, TNFRSF5/CD40, TNFRSF1B/TNF-R75, ETS1, ETS2, FLI1, SMAD3 and ACVR1B/ALK4. Nucleus Nucleus, PML body Nucleus, nucleolus Cytoplasm Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein. Widely expressed (PubMed:10764746). Expressed in whole brain, cerebellum, quiescent cortical astrocytes and cerebellar granule neurons (PubMed:24658003). Ubiquitinated by TRAF6. Can partially complement the absence of Tdp1 due to its weak 3'-tyrosyl DNA phosphodiesterase activity. Belongs to the CCR4/nocturin family. magnesium ion binding single-stranded DNA binding nuclease activity endonuclease activity nucleus nucleoplasm nucleolus cytoplasm DNA repair double-strand break repair cellular response to DNA damage stimulus phosphoric diester hydrolase activity aggresome nuclear body PML body hydrolase activity manganese ion binding tyrosyl-RNA phosphodiesterase activity metal ion binding neuron development 5'-tyrosyl-DNA phosphodiesterase activity nucleic acid phosphodiester bond hydrolysis uc007pwl.1 uc007pwl.2 uc007pwl.3 uc007pwl.4 
ENSMUST00000038053.14 Lpp ENSMUST00000038053.14 LIM domain containing preferred translocation partner in lipoma, transcript variant 1 (from RefSeq NM_178665.5) ENSMUST00000038053.1 ENSMUST00000038053.10 ENSMUST00000038053.11 ENSMUST00000038053.12 ENSMUST00000038053.13 ENSMUST00000038053.2 ENSMUST00000038053.3 ENSMUST00000038053.4 ENSMUST00000038053.5 ENSMUST00000038053.6 ENSMUST00000038053.7 ENSMUST00000038053.8 ENSMUST00000038053.9 LPP_MOUSE NM_178665 Q5U407 Q8BFW7 Q8BHI1 Q8BKI0 Q8BKN2 Q8BLF4 Q8BLG3 Q8C101 uc007yue.1 uc007yue.2 uc007yue.3 uc007yue.4 May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus (By similarity). Interacts with VASP, with PDZ domains of SCRIB and with ACTN1/alpha-actinin. Nucleus Cytoplasm Cell junction Note=Found in the nucleus, in the cytoplasm and at cell adhesion sites. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8BFW7-1; Sequence=Displayed; Name=2; IsoId=Q8BFW7-2; Sequence=VSP_016353, VSP_016354; Name=3; IsoId=Q8BFW7-3; Sequence=VSP_016351, VSP_016353, VSP_016354; Name=4; IsoId=Q8BFW7-4; Sequence=VSP_016350, VSP_016352; Name=5; IsoId=Q8BFW7-5; Sequence=VSP_016355, VSP_016356; Fusion protein carrying the DNA-binding domains of HMGA2/HMGIC and the LIM domain of LPP causes malignant transformation of NIH3T3 cells. Belongs to the zyxin/ajuba family. stress fiber protein binding nucleus cytoplasm cytosol focal adhesion cell adhesion cell junction metal ion binding cell-cell adhesion uc007yue.1 uc007yue.2 uc007yue.3 uc007yue.4 
ENSMUST00000038069.9 Ceacam10 ENSMUST00000038069.9 CEA cell adhesion molecule 10, transcript variant 1 (from RefSeq NM_007675.4) A0A0R4J0G1 A0A0R4J0G1_MOUSE Ceacam10 ENSMUST00000038069.1 ENSMUST00000038069.2 ENSMUST00000038069.3 ENSMUST00000038069.4 ENSMUST00000038069.5 ENSMUST00000038069.6 ENSMUST00000038069.7 ENSMUST00000038069.8 NM_007675 uc009fqm.1 uc009fqm.2 uc009fqm.3 uc009fqm.4 uc009fqm.5 Belongs to the immunoglobulin superfamily. CEA family. uc009fqm.1 uc009fqm.2 uc009fqm.3 uc009fqm.4 uc009fqm.5 
ENSMUST00000038073.5 Catsper2 ENSMUST00000038073.5 cation channel, sperm associated 2 (from RefSeq NM_153075.3) A0A0A0MQ85 A0A0A0MQ85_MOUSE Catsper2 ENSMUST00000038073.1 ENSMUST00000038073.2 ENSMUST00000038073.3 ENSMUST00000038073.4 NM_153075 uc012ccq.1 uc012ccq.2 uc012ccq.3 ion channel activity calcium activated cation channel activity ion transport membrane integral component of membrane flagellated sperm motility ion transmembrane transport CatSper complex transmembrane transport uc012ccq.1 uc012ccq.2 uc012ccq.3 
ENSMUST00000038075.12 Ggact ENSMUST00000038075.12 gamma-glutamylamine cyclotransferase, transcript variant 4 (from RefSeq NM_145466.3) A2ld1 ENSMUST00000038075.1 ENSMUST00000038075.10 ENSMUST00000038075.11 ENSMUST00000038075.2 ENSMUST00000038075.3 ENSMUST00000038075.4 ENSMUST00000038075.5 ENSMUST00000038075.6 ENSMUST00000038075.7 ENSMUST00000038075.8 ENSMUST00000038075.9 GGACT_MOUSE NM_145466 Q66JP0 Q923B0 uc011zqm.1 uc011zqm.2 uc011zqm.3 Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl- alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine. Reaction=epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L- lysine; Xref=Rhea:RHEA:16961, ChEBI:CHEBI:32551, ChEBI:CHEBI:58402, ChEBI:CHEBI:133752; EC=4.3.2.8; Evidence=; Monomer. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q923B0-1; Sequence=Displayed; Name=2; IsoId=Q923B0-2; Sequence=VSP_031641, VSP_031642; Belongs to the gamma-glutamylcyclotransferase family. cytosol lyase activity cellular modified amino acid catabolic process uc011zqm.1 uc011zqm.2 uc011zqm.3 
ENSMUST00000038091.8 Sde2 ENSMUST00000038091.8 SDE2 telomere maintenance homolog (S. pombe) (from RefSeq NM_145943.1) ENSMUST00000038091.1 ENSMUST00000038091.2 ENSMUST00000038091.3 ENSMUST00000038091.4 ENSMUST00000038091.5 ENSMUST00000038091.6 ENSMUST00000038091.7 NM_145943 Q8BJX1 Q8K1J5 SDE2_MOUSE uc007dwt.1 uc007dwt.2 uc007dwt.3 uc007dwt.4 Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (By similarity). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (By similarity). Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (By similarity). May recruit CACTIN to the spliceosome (By similarity). Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (By similarity). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (By similarity). Interacts (via PIP-box) with PCNA; the interaction is direct and prevents ultraviolet light induced monoubiquitination of PCNA (By similarity). Interacts with FBL/fibrillarin (By similarity). Interacts with CACTIN (By similarity). Interacts with SF3B1 (By similarity). Interacts with U2AF1 (By similarity). Nucleus Cytoplasm The PIP-box (PCNA interacting peptide) motif mediates both the interaction with PCNA and cleavage of the SDE2 precursor by a deubiquitinating enzyme. The SAP domain is necessary for specific binding to DNA. The propeptide displays a ubiquitin-like fold. Upon binding to PCNA, the N-terminal UBL (ubiquitin-like) propeptide is cleaved at Gly-77 by an unidentified deubiquitinating enzyme; the resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Both SDE2-UBL and the mature SDE2 are polyubiquitinated. Belongs to the SDE2 family. DNA binding damaged DNA binding nucleus DNA replication cell cycle protein processing protein ubiquitination cellular response to UV cell division regulation of cell cycle arrest uc007dwt.1 uc007dwt.2 uc007dwt.3 uc007dwt.4 
ENSMUST00000038096.8 Fn3krp ENSMUST00000038096.8 fructosamine 3 kinase related protein (from RefSeq NM_181420.3) B1ATT5 ENSMUST00000038096.1 ENSMUST00000038096.2 ENSMUST00000038096.3 ENSMUST00000038096.4 ENSMUST00000038096.5 ENSMUST00000038096.6 ENSMUST00000038096.7 Fn3krp KT3K_MOUSE NM_181420 Q8K274 uc007mvv.1 uc007mvv.2 uc007mvv.3 uc007mvv.4 Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosphate and psicoselysine-3 phosphate, respectively (PubMed:14633848). Ribuloselysine-3 phosphate and psicoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:14633848). Not able to phosphorylate fructoselysine (PubMed:14633848). Reaction=ATP + N(6)-D-ribulosyl-L-lysyl-[protein] = ADP + H(+) + N(6)- (3-O-phospho-D-ribulosyl)-L-lysyl-[protein]; Xref=Rhea:RHEA:48432, Rhea:RHEA-COMP:12103, Rhea:RHEA-COMP:12104, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:90418, ChEBI:CHEBI:90420, ChEBI:CHEBI:456216; EC=2.7.1.172; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48433; Evidence=; Reaction=ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)- (3-O-phospho-D-psicosyl)-L-lysyl-[protein]; Xref=Rhea:RHEA:61392, Rhea:RHEA-COMP:15796, Rhea:RHEA-COMP:15797, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:144621, ChEBI:CHEBI:144622, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61393; Evidence=; The ATP-binding domain is structurally related to aminoglycoside phosphotransferase family. Belongs to the fructosamine kinase family. cellular_component kinase activity phosphorylation transferase activity uc007mvv.1 uc007mvv.2 uc007mvv.3 uc007mvv.4 
ENSMUST00000038104.12 Bdp1 ENSMUST00000038104.12 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB (from RefSeq NM_001081061.1) BDP1_MOUSE ENSMUST00000038104.1 ENSMUST00000038104.10 ENSMUST00000038104.11 ENSMUST00000038104.2 ENSMUST00000038104.3 ENSMUST00000038104.4 ENSMUST00000038104.5 ENSMUST00000038104.6 ENSMUST00000038104.7 ENSMUST00000038104.8 ENSMUST00000038104.9 Kiaa1241 NM_001081061 Q571C7 Q8BTI4 Q8K0U7 Tfnr uc007rqc.1 uc007rqc.2 General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site (By similarity). Component of TFIIIB complex. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha and TFIIIB-beta activities are required for transcription of genes with TFIIIC-bound internal promoters and PSE transcription factor-bound external promoters, respectively. The TFIIIB-alpha activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated proteins; YY1 facilitates the formation of TFIIIB-alpha activity complex. The TFIIIB-beta activity complex is composed of TBP, BDP1, and BRF1. Interacts with BRF1; this interaction diminishes during mitosis resulting in the release of BDP1 from chromosomal templates. Component of TFIIIC complex. The TFIIIC complex has two activities, C1 and C2. The TFIIIC2 activity complex is only required for transcription of the 'classical' pol III genes whereas the TFIIIC1 activity complex is required for transcription of all pol III genes. The TFIIIC1 activity complex is composed at least of BDP1. Interacts with ZBTB43 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q571C7-1; Sequence=Displayed; Name=2; IsoId=Q571C7-2; Sequence=VSP_033583; Expressed in the cochlea, particularly in the spiral ligament, the capillaries of the stria vascularis and the basilar membrane. Phosphorylated by CSNK2A1 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. Sequence=AAH30359.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; transcription factor TFIIIB complex TFIIIC-class transcription factor binding DNA binding nucleus regulation of transcription, DNA-templated RNA polymerase III transcriptional preinitiation complex assembly uc007rqc.1 uc007rqc.2 
ENSMUST00000038107.9 Cited2 ENSMUST00000038107.9 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 (from RefSeq NM_010828.3) CITE2_MOUSE ENSMUST00000038107.1 ENSMUST00000038107.2 ENSMUST00000038107.3 ENSMUST00000038107.4 ENSMUST00000038107.5 ENSMUST00000038107.6 ENSMUST00000038107.7 ENSMUST00000038107.8 Mrg1 Msg2 NM_010828 O35740 O35741 O35742 O35743 O55198 Q6PGA9 uc007elt.1 uc007elt.2 uc007elt.3 uc007elt.4 Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. Interacts (via C-terminus) with EP300 (via CH1 domain); the interaction is stimulated in response to hypoxia. Interacts with PPARA. Interacts (via C-terminus) with TFAP2A, TFAP2B and TFAP2C (By similarity). Interacts (via C-terminus) with SMAD2. Interacts (via C- terminus) with SMAD3 (via MH2 domain). Interacts with LHX2 (via LIM domains). Interacts with WT1 isoform 1 and isoform 3. Nucleus. Note=Colocalizes with EP300 in dot-like structures. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O35740-1; Sequence=Displayed; Name=2; IsoId=O35740-2; Sequence=VSP_001090; Name=3; IsoId=O35740-3; Sequence=VSP_001091; Name=4; IsoId=O35740-4; Sequence=VSP_001092; Ubiquitous. Expressed in the embryonic heart. Expressed in the ventral node, cardiac crescent and blood islands at 7.5 dpc. Expressed in the cardiac crescent, anterior lateral mesoderm and in trunk paraxial mesoderm at 8 dpc. Expressed in forebrain-midbrain boundary, branchial arches 1 and 2, heart and somites at 9.5 dpc (at protein level). Expressed in the coelomic epithelium and in cells in the underlying nephrogenic mesenchyme of the genital ridge at 10 dpc. Expressed in the genital ridge and the presumptive adrenal area at 10.5 dpc. Expressed in the gonad and in the adrenal anlagen at 12 dpc. Expressed in the cells of the adrenal cortex at 14 dpc. Expressed throughout the embryonic heart, as well as in the node and the lateral plate mesoderm (LPM), that are responsible for initiating and maintaining left-right patterning. Expressed in the crown cells of the node. Mice embryos die during gestation with left-right patterning defects and severe developmental abnormalities, including cardiac malformations, exencephaly and adrenal agenesis. Show also impaired mesonephric tubules and adrenal cortex development in embryos. Belongs to the CITED family. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II activating transcription factor binding blood vessel development vasculogenesis response to hypoxia in utero embryonic development trophectodermal cell differentiation neural tube formation neural tube closure liver development embryonic placenta development vasculature development heart looping lens morphogenesis in camera-type eye hematopoietic progenitor cell differentiation leukocyte differentiation outflow tract morphogenesis regulation of animal organ formation endocardial cushion development ventricular septum development chromatin binding transcription factor activity, sequence-specific DNA binding transcription cofactor activity transcription coactivator activity transcription corepressor activity protein binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway multicellular organism development determination of left/right symmetry central nervous system development peripheral nervous system development heart development sex determination cell aging cell proliferation male gonad development response to mechanical stimulus positive regulation of gene expression negative regulation of gene expression protein domain specific binding cranial nerve morphogenesis positive regulation of cell-cell adhesion cell differentiation adrenal gland development negative regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway granulocyte differentiation macromolecular complex response to fluid shear stress histone acetyltransferase binding positive regulation of peroxisome proliferator activated receptor signaling pathway adrenal cortex formation skeletal muscle cell differentiation negative regulation of apoptotic process response to estrogen positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter SMAD binding decidualization spleen development thymus development embryonic camera-type eye morphogenesis erythrocyte development LBD domain binding negative regulation of cardiac muscle cell proliferation embryonic process involved in female pregnancy bone morphogenesis cardiac septum morphogenesis ventricular septum morphogenesis embryonic heart tube left/right pattern formation pulmonary artery morphogenesis cardiac neural crest cell development involved in heart development determination of heart left/right asymmetry negative regulation of transcription from RNA polymerase II promoter in response to hypoxia left/right axis specification cellular response to growth factor stimulus nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry positive regulation of nucleic acid-templated transcription positive regulation of male gonad development branching involved in ureteric bud morphogenesis kidney development morphogenesis of an epithelium uc007elt.1 uc007elt.2 uc007elt.3 uc007elt.4 
ENSMUST00000038108.12 Ndufc1 ENSMUST00000038108.12 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (from UniProt Q9CQY9) AK028011 ENSMUST00000038108.1 ENSMUST00000038108.10 ENSMUST00000038108.11 ENSMUST00000038108.2 ENSMUST00000038108.3 ENSMUST00000038108.4 ENSMUST00000038108.5 ENSMUST00000038108.6 ENSMUST00000038108.7 ENSMUST00000038108.8 ENSMUST00000038108.9 NDUC1_MOUSE Q58DY9 Q9CQY9 uc008pdy.1 uc008pdy.2 uc008pdy.3 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side Belongs to the complex I NDUFC1 subunit family. molecular_function mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I membrane integral component of membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc008pdy.1 uc008pdy.2 uc008pdy.3 
ENSMUST00000038116.13 Ankrd12 ENSMUST00000038116.13 ankyrin repeat domain 12 (from RefSeq NM_001025572.1) Ankrd12 ENSMUST00000038116.1 ENSMUST00000038116.10 ENSMUST00000038116.11 ENSMUST00000038116.12 ENSMUST00000038116.2 ENSMUST00000038116.3 ENSMUST00000038116.4 ENSMUST00000038116.5 ENSMUST00000038116.6 ENSMUST00000038116.7 ENSMUST00000038116.8 ENSMUST00000038116.9 G5E893 G5E893_MOUSE NM_001025572 uc008dgs.1 uc008dgs.2 uc008dgs.3 molecular_function nucleoplasm cytosol biological_process uc008dgs.1 uc008dgs.2 uc008dgs.3 
ENSMUST00000038128.15 Tmem109 ENSMUST00000038128.15 transmembrane protein 109 (from RefSeq NM_134142.1) ENSMUST00000038128.1 ENSMUST00000038128.10 ENSMUST00000038128.11 ENSMUST00000038128.12 ENSMUST00000038128.13 ENSMUST00000038128.14 ENSMUST00000038128.2 ENSMUST00000038128.3 ENSMUST00000038128.4 ENSMUST00000038128.5 ENSMUST00000038128.6 ENSMUST00000038128.7 ENSMUST00000038128.8 ENSMUST00000038128.9 NM_134142 Q3UBX0 Q8R006 TM109_MOUSE Tmem109 uc008gre.1 uc008gre.2 uc008gre.3 uc008gre.4 uc008gre.5 Functions as a voltage-gated monoatomic cation channel permeable to both potassium and calcium (By similarity). Plays a role in the cellular response to DNA damage (PubMed:20060811). Reaction=K(+)(in) = K(+)(out); Xref=Rhea:RHEA:29463, ChEBI:CHEBI:29103; Evidence=; Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671, ChEBI:CHEBI:29108; Evidence=; Homooligomer. Interacts with CRYAB; in the cellular response to DNA damage. Q3UBX0; P02511: CRYAB; Xeno; NbExp=2; IntAct=EBI-2366300, EBI-739060; Nucleus outer membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Sarcoplasmic reticulum membrane ; Multi-pass membrane protein Viable and normal in appearance. voltage-gated ion channel activity protein binding nucleus nuclear outer membrane endoplasmic reticulum endoplasmic reticulum membrane ion transport membrane integral component of membrane sarcoplasmic reticulum nuclear membrane sarcoplasmic reticulum membrane ion transmembrane transport regulation of ion transmembrane transport intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of cell death cellular response to gamma radiation uc008gre.1 uc008gre.2 uc008gre.3 uc008gre.4 uc008gre.5 
ENSMUST00000038131.10 Rfc3 ENSMUST00000038131.10 replication factor C (activator 1) 3, transcript variant 1 (from RefSeq NM_027009.3) ENSMUST00000038131.1 ENSMUST00000038131.2 ENSMUST00000038131.3 ENSMUST00000038131.4 ENSMUST00000038131.5 ENSMUST00000038131.6 ENSMUST00000038131.7 ENSMUST00000038131.8 ENSMUST00000038131.9 NM_027009 Q8R323 RFC3_MOUSE uc009aus.1 uc009aus.2 uc009aus.3 The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA (By similarity). Interacts with CNTD1; this interaction facilitates crossover formation (PubMed:32640224). Nucleus Belongs to the activator 1 small subunits family. DNA binding DNA clamp loader activity nucleus DNA replication factor C complex DNA replication DNA-dependent DNA replication ATPase activity single-stranded DNA-dependent ATP-dependent DNA helicase activity Ctf18 RFC-like complex DNA duplex unwinding response to organophosphorus positive regulation of DNA-directed DNA polymerase activity uc009aus.1 uc009aus.2 uc009aus.3 
ENSMUST00000038141.15 Slfn8 ENSMUST00000038141.15 schlafen 8, transcript variant 1 (from RefSeq NM_181545.4) A0A0A0MQG0 B1ARD8 ENSMUST00000038141.1 ENSMUST00000038141.10 ENSMUST00000038141.11 ENSMUST00000038141.12 ENSMUST00000038141.13 ENSMUST00000038141.14 ENSMUST00000038141.2 ENSMUST00000038141.3 ENSMUST00000038141.4 ENSMUST00000038141.5 ENSMUST00000038141.6 ENSMUST00000038141.7 ENSMUST00000038141.8 ENSMUST00000038141.9 F6RTS1 NM_181545 Q3UBN9 Q7TMF1 SLFN8_MOUSE Slfn8 uc007kod.1 uc007kod.2 uc007kod.3 Endoribonuclease that cleaves tRNAs and rRNAs (PubMed:29563550). Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem (PubMed:29563550). May be involved in immune system via regulation of inflammation (PubMed:29528433). Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Can also use Mn(2+). ; Cytoplasm In T-cells, expressed at relatively constant levels during development: expressed in immature CD3(-)CD4(-)CD8(-) T-cells (DN stage), in CD4(+)CD8(+) double-positive stage (DP) and mature CD4(+) or CD8(+) thymocytes. Expression is slightly reduced at the DP stage. Induced following infection. Shows a pseudo-dimeric U-pillow-shaped architecture of the SLFN13 N'-domain that may clamp base-paired RNAs. No visible phenotype in normal conditions. Mice are resistant in experimental autoimmune encephalomyelitis (EAE) model, a T-cell-mediated autoimmune model. The expression of pro-inflammatory mediators is severely reduced in EAE. No dysfunction of T-cells, or other leukocytes is detected. Belongs to the Schlafen family. Subgroup III subfamily. tRNA binding nucleotide binding immune system process nuclease activity endonuclease activity endoribonuclease activity ATP binding cytoplasm zinc ion binding rRNA catabolic process tRNA catabolic process hydrolase activity metal ion binding defense response to virus nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc007kod.1 uc007kod.2 uc007kod.3 
ENSMUST00000038144.9 Esm1 ENSMUST00000038144.9 endothelial cell-specific molecule 1 (from RefSeq NM_023612.3) ENSMUST00000038144.1 ENSMUST00000038144.2 ENSMUST00000038144.3 ENSMUST00000038144.4 ENSMUST00000038144.5 ENSMUST00000038144.6 ENSMUST00000038144.7 ENSMUST00000038144.8 ESM1_MOUSE NM_023612 Q9QYY7 uc007rxe.1 uc007rxe.2 uc007rxe.3 Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions (By similarity). Secreted O-glycosylated; contains chondroitin sulfate and dermatan sulfate. angiogenesis sprouting angiogenesis hepatocyte growth factor receptor binding integrin binding insulin-like growth factor binding cellular_component extracellular region positive regulation of cell proliferation positive regulation of hepatocyte growth factor receptor signaling pathway uc007rxe.1 uc007rxe.2 uc007rxe.3 
ENSMUST00000038149.13 Pbx2 ENSMUST00000038149.13 pre B cell leukemia homeobox 2 (from RefSeq NM_017463.3) ENSMUST00000038149.1 ENSMUST00000038149.10 ENSMUST00000038149.11 ENSMUST00000038149.12 ENSMUST00000038149.2 ENSMUST00000038149.3 ENSMUST00000038149.4 ENSMUST00000038149.5 ENSMUST00000038149.6 ENSMUST00000038149.7 ENSMUST00000038149.8 ENSMUST00000038149.9 NM_017463 Pbx2 Q4FJL3 Q4FJL3_MOUSE uc008ccv.1 uc008ccv.2 uc008ccv.3 Nucleus Belongs to the TALE/PBX homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated transcription factor binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc008ccv.1 uc008ccv.2 uc008ccv.3 
ENSMUST00000038154.12 Mgarp ENSMUST00000038154.12 mitochondria localized glutamic acid rich protein, transcript variant 1 (from RefSeq NM_026358.3) Cesp1 ENSMUST00000038154.1 ENSMUST00000038154.10 ENSMUST00000038154.11 ENSMUST00000038154.2 ENSMUST00000038154.3 ENSMUST00000038154.4 ENSMUST00000038154.5 ENSMUST00000038154.6 ENSMUST00000038154.7 ENSMUST00000038154.8 ENSMUST00000038154.9 HUMMR_MOUSE Hummr NM_026358 Osap Q8VI64 Q96EB2 Q9D9Y5 uc008pdx.1 uc008pdx.2 uc008pdx.3 uc008pdx.4 uc008pdx.5 Plays a role in the trafficking of mitochondria along microtubules (PubMed:19325000). Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia (PubMed:19325000). Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion (PubMed:19325000). Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (PubMed:19528298). Plays an inhibitory role during neocortex development by regulating mitochondrial morphology, distribution and motility in neocortical neurons (PubMed:24323429). Interacts with RHOT1/Miro-1, RHOT2/Miro-2, TRAK1/OIP106 and TRAK2/GRIF1. Mitochondrion tochondrion outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side Mitochondrion inner membrane ; Single-pass type IV membrane protein ; Cytoplasmic side Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion. Expressed in the ovary, testis, brain, adrenal glands and the compartments of the visual nervous system. Expressed in corneal endothelium (CE) (at protein level). Expressed in steroidogenic tissues with the highest level of expression observed in the adrenal gland. Weakly expressed in placenta. Weakly expressed in astrocytes and neurons under normoxia. Strongly expressed in astrocytes and neurons under hypoxia. Expressed in each layer of the retina, with particularly higher staining in the inner segment of the photoreceptor (IS), the outer plexiform layer (OPL) and the ganglion cell layer (GCL). Up-regulated by chorionic gonadotropin in ovary. Up- regulated by hypoxia in a HIF-1A-dependent manner in neurons and astrocytes. Up-regulated during gonad development after birth, probably under the regulation of hormones derived from the hypothalamic- pituitary-gonadal (HPG) axis. Reduction of mitochondrial motion in the anterograde direction and increase of mitochondrial motion in the retrograde direction in response to hypoxia (PubMed:19528298). The number of motile mitochondria is not altered (PubMed:19528298). Neocortical neurons exhibit a remarkable increase of the dendritic number and the axon length (PubMed:24323429). Neuronal cells show an increase in the percentage of round mitochondria and a decrease in the percentage of rod or tubular mitochondria (PubMed:24323429). protein binding mitochondrion mitochondrial outer membrane protein targeting to mitochondrion anterograde axonal transport retrograde axonal transport positive regulation of mitochondrion organization membrane integral component of membrane axonal transport of mitochondrion integral component of mitochondrial outer membrane cellular response to steroid hormone stimulus cellular response to hypoxia cellular response to gonadotropin-releasing hormone axon cytoplasm uc008pdx.1 uc008pdx.2 uc008pdx.3 uc008pdx.4 uc008pdx.5 
ENSMUST00000038160.6 Lum ENSMUST00000038160.6 lumican (from RefSeq NM_008524.2) ENSMUST00000038160.1 ENSMUST00000038160.2 ENSMUST00000038160.3 ENSMUST00000038160.4 ENSMUST00000038160.5 LUM_MOUSE Lcn Ldc NM_008524 P51885 Q3TP25 Q99JZ3 Q9CXK0 uc007gwz.1 uc007gwz.2 uc007gwz.3 uc007gwz.4 Binds to laminin. Secreted, extracellular space, extracellular matrix Cornea and other tissues. Contains keratan sulfate. Cys-37, Cys-41, Cys-43 and Cys-53 are involved in disulfide bonds. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. collagen binding extracellular region fibrillar collagen trimer extracellular space visual perception response to organic cyclic compound extracellular matrix structural constituent conferring compression resistance collagen fibril organization extracellular matrix positive regulation of transforming growth factor beta1 production positive regulation of transcription from RNA polymerase II promoter cartilage development response to growth factor uc007gwz.1 uc007gwz.2 uc007gwz.3 uc007gwz.4 
ENSMUST00000038161.5 Agmat ENSMUST00000038161.5 agmatinase, transcript variant 1 (from RefSeq NM_001378862.1) A2AS89 ENSMUST00000038161.1 ENSMUST00000038161.2 ENSMUST00000038161.3 ENSMUST00000038161.4 GDAH_MOUSE Gdah NM_001378862 Q14BN7 uc008vpe.1 uc008vpe.2 uc008vpe.3 Hydrolyzes linear guanidino acids to form urea and the corresponding amines. Displays specificity for substrates having a negatively charged head group and short chains including taurocyamine, guanidino propanoic and butanoic acids. May protect cells by detoxifying potentially harmful amounts of guanidino acids. Metabolizes L-arginine with low efficiency. Reaction=3-guanidinopropanoate + H2O = beta-alanine + urea; Xref=Rhea:RHEA:16029, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:57593, ChEBI:CHEBI:57966; EC=3.5.3.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16030; Evidence=; Reaction=4-guanidinobutanoate + H2O = 4-aminobutanoate + urea; Xref=Rhea:RHEA:19501, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:57486, ChEBI:CHEBI:59888; EC=3.5.3.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19502; Evidence=; Reaction=H2O + taurocyamine = taurine + urea; Xref=Rhea:RHEA:75931, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:58064, ChEBI:CHEBI:507393; EC=3.5.3.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75932; Evidence=; Reaction=H2O + L-arginine = L-ornithine + urea; Xref=Rhea:RHEA:20569, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:32682, ChEBI:CHEBI:46911; EC=3.5.3.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20570; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Nitrogen metabolism; urea cycle; L-ornithine and urea from L- arginine: step 1/1. Mitochondrion Detected only in liver. Belongs to the arginase family. Agmatinase subfamily. May have little or no activity due to the lack of several residues essential for manganese binding and catalytic activity. mitochondrion spermidine biosynthetic process agmatinase activity putrescine biosynthetic process hydrolase activity putrescine biosynthetic process from arginine putrescine biosynthetic process from arginine, using agmatinase metal ion binding uc008vpe.1 uc008vpe.2 uc008vpe.3 
ENSMUST00000038163.8 Pnma8a ENSMUST00000038163.8 PNMA family member 8A (from RefSeq NM_001007569.2) ENSMUST00000038163.1 ENSMUST00000038163.2 ENSMUST00000038163.3 ENSMUST00000038163.4 ENSMUST00000038163.5 ENSMUST00000038163.6 ENSMUST00000038163.7 NM_001007569 PNM8A_MOUSE Pnma8a Pnmal1 Q80VM8 Q8C533 uc009fip.1 uc009fip.2 uc009fip.3 Belongs to the PNMA family. molecular_function cellular_component biological_process uc009fip.1 uc009fip.2 uc009fip.3 
ENSMUST00000038169.8 Mif ENSMUST00000038169.8 macrophage migration inhibitory factor (glycosylation-inhibiting factor) (from RefSeq NM_010798.3) ENSMUST00000038169.1 ENSMUST00000038169.2 ENSMUST00000038169.3 ENSMUST00000038169.4 ENSMUST00000038169.5 ENSMUST00000038169.6 ENSMUST00000038169.7 Mif NM_010798 Q545F0 Q545F0_MOUSE uc007ftc.1 uc007ftc.2 uc007ftc.3 Reaction=3-phenylpyruvate = enol-phenylpyruvate; Xref=Rhea:RHEA:17097, ChEBI:CHEBI:16815, ChEBI:CHEBI:18005; EC=5.3.2.1; Evidence=; Reaction=L-dopachrome = 5,6-dihydroxyindole-2-carboxylate; Xref=Rhea:RHEA:13041, ChEBI:CHEBI:16875, ChEBI:CHEBI:57509; EC=5.3.3.12; Evidence=; Secreted Belongs to the MIF family. prostaglandin biosynthetic process dopachrome isomerase activity receptor binding cytokine activity cytokine receptor binding extracellular region extracellular space nucleoplasm cytoplasm cytosol plasma membrane cell surface receptor signaling pathway cell proliferation cell surface negative regulation of gene expression positive regulation of protein kinase A signaling negative regulation of macrophage chemotaxis carboxylic acid metabolic process negative regulation of cell migration positive regulation of B cell proliferation positive regulation of tumor necrosis factor production positive regulation of peptidyl-serine phosphorylation chemoattractant activity positive regulation of phosphorylation identical protein binding negative regulation of apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of fibroblast proliferation phenylpyruvate tautomerase activity positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation positive chemotaxis protein homotrimerization positive regulation of ERK1 and ERK2 cascade negative regulation of cell cycle arrest negative regulation of cell aging negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator uc007ftc.1 uc007ftc.2 uc007ftc.3 
ENSMUST00000038172.16 Mtmr12 ENSMUST00000038172.16 myotubularin related protein 12, transcript variant 1 (from RefSeq NM_172958.4) ENSMUST00000038172.1 ENSMUST00000038172.10 ENSMUST00000038172.11 ENSMUST00000038172.12 ENSMUST00000038172.13 ENSMUST00000038172.14 ENSMUST00000038172.15 ENSMUST00000038172.2 ENSMUST00000038172.3 ENSMUST00000038172.4 ENSMUST00000038172.5 ENSMUST00000038172.6 ENSMUST00000038172.7 ENSMUST00000038172.8 ENSMUST00000038172.9 Kiaa1682 MTMRC_MOUSE NM_172958 Q80TA6 Q8BVX4 Q8C0P1 uc007vhl.1 uc007vhl.2 uc007vhl.3 Acts as an adapter for the myotubularin-related phosphatases (PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (PubMed:23818870). Heterodimer with lipid phosphatase MTM1 (PubMed:23818870). Heterodimer with lipid phosphatase MTMR2 (By similarity). Cytoplasm Sarcoplasmic reticulum Cytoplasm, myofibril, sarcomere Note=Localizes to punctate vesicles when associated with MTM1 (By similarity). Localizes to triads, a structure formed by a T tubule and two sarcoplasmic reticulum terminal cisterna (PubMed:23818870). In skeletal muscles, co- localizes with MTM1 in the sarcomere (PubMed:23818870). Partially localizes to the sarcoplasmic reticulum in skeletal muscles (PubMed:23818870). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80TA6-1; Sequence=Displayed; Name=2; IsoId=Q80TA6-2; Sequence=VSP_030723; Expressed in skeletal muscles (at protein level). Expression increases during skeletal muscle cell differentiation followed by a decrease at later stages of differentiation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 391 in the dsPTPase catalytic loop and does not have phosphatase activity. Sequence=BAC36227.1; Type=Erroneous initiation; Evidence=; Sequence=BAC65821.1; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm sarcoplasmic reticulum phosphatase regulator activity sarcomere regulation of catalytic activity toxin transport uc007vhl.1 uc007vhl.2 uc007vhl.3 
ENSMUST00000038174.8 Got1l1 ENSMUST00000038174.8 glutamic-oxaloacetic transaminase 1-like 1 (from RefSeq NM_029674.1) AATC2_MOUSE ENSMUST00000038174.1 ENSMUST00000038174.2 ENSMUST00000038174.3 ENSMUST00000038174.4 ENSMUST00000038174.5 ENSMUST00000038174.6 ENSMUST00000038174.7 NM_029674 Q7TSV6 Q9D9F3 uc009lic.1 uc009lic.2 Reaction=2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate; Xref=Rhea:RHEA:21824, ChEBI:CHEBI:16452, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:29991; EC=2.6.1.1; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Homodimer. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TSV6-1; Sequence=Displayed; Name=2; IsoId=Q7TSV6-2; Sequence=VSP_033430; In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. The residues that bind the substrate in other aspartate aminotransferases are not conserved. catalytic activity L-aspartate:2-oxoglutarate aminotransferase activity cytoplasm cytosol cellular amino acid metabolic process aspartate biosynthetic process transaminase activity biosynthetic process transferase activity pyridoxal phosphate binding uc009lic.1 uc009lic.2 
ENSMUST00000038176.15 Lilra6 ENSMUST00000038176.15 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6, transcript variant 1 (from RefSeq NM_011090.2) A0A0B4J1F3 A0A0B4J1F3_MOUSE ENSMUST00000038176.1 ENSMUST00000038176.10 ENSMUST00000038176.11 ENSMUST00000038176.12 ENSMUST00000038176.13 ENSMUST00000038176.14 ENSMUST00000038176.2 ENSMUST00000038176.3 ENSMUST00000038176.4 ENSMUST00000038176.5 ENSMUST00000038176.6 ENSMUST00000038176.7 ENSMUST00000038176.8 ENSMUST00000038176.9 Lilra6 NM_011090 uc009ewp.1 uc009ewp.2 uc009ewp.3 uc009ewp.4 molecular_function cellular_component biological_process uc009ewp.1 uc009ewp.2 uc009ewp.3 uc009ewp.4 
ENSMUST00000038185.10 Exd2 ENSMUST00000038185.10 exonuclease 3'-5' domain containing 2 (from RefSeq NM_133798.3) ENSMUST00000038185.1 ENSMUST00000038185.2 ENSMUST00000038185.3 ENSMUST00000038185.4 ENSMUST00000038185.5 ENSMUST00000038185.6 ENSMUST00000038185.7 ENSMUST00000038185.8 ENSMUST00000038185.9 EXD2_MOUSE Exd2 Exdl2 F8WID1 NM_133798 Q3TPJ5 Q3TS84 Q8VEG4 uc007oas.1 uc007oas.2 uc007oas.3 uc007oas.4 Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor. In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation. Also involved in the response to DNA damage. Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'- 5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks. Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation. Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Divalent metal cations; Mg(2+) or Mn(2+). Acts as a 3'-5' exoribonuclease in presence of Mg(2+), while it has no 3'-5' exodeoxyribonuclease activity. Has both as a 3'-5' exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+). ; Homodimer. Interacts with RBBP8, MRE11 and BRCA1. Mitochondrion outer membrane ; Single-pass membrane protein Mitochondrion matrix Nucleus Chromosome Note=Mainly localizes to the mitochondrial outer membrane. May translocate to the nucleus in response to DNA damage; however mechanism that explain nuclear localization are unknown and require experimental evidences. Recruited to replication forks following replication stress. Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=Q8VEG4-1; Sequence=Displayed; Name=2; IsoId=Q8VEG4-2; Sequence=VSP_058326; Belongs to the EXD2 family. double-strand break repair via homologous recombination DNA double-strand break processing nucleic acid binding nuclease activity exonuclease activity nucleus cytoplasm nucleobase-containing compound metabolic process double-strand break repair single-stranded DNA 3'-5' exodeoxyribonuclease activity 3'-5' exonuclease activity exodeoxyribonuclease I activity hydrolase activity nucleic acid phosphodiester bond hydrolysis uc007oas.1 uc007oas.2 uc007oas.3 uc007oas.4 
ENSMUST00000038193.15 Wdr59 ENSMUST00000038193.15 WD repeat domain 59, transcript variant 6 (from RefSeq NR_175299.1) Cdw12 ENSMUST00000038193.1 ENSMUST00000038193.10 ENSMUST00000038193.11 ENSMUST00000038193.12 ENSMUST00000038193.13 ENSMUST00000038193.14 ENSMUST00000038193.2 ENSMUST00000038193.3 ENSMUST00000038193.4 ENSMUST00000038193.5 ENSMUST00000038193.6 ENSMUST00000038193.7 ENSMUST00000038193.8 ENSMUST00000038193.9 Kiaa1923 NR_175299 Q3TC49 Q3UWJ3 Q69Z65 Q6NZK7 Q8BLZ2 Q8BWK9 Q8C0M0 WDR59_MOUSE Wdr59 uc009nmj.1 uc009nmj.2 uc009nmj.3 uc009nmj.4 As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids. In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated. Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids (By similarity). Interacts with DDB1-CUL4A/B E3 ligase complexes (PubMed:17041588). Lysosome membrane Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C0M0-1; Sequence=Displayed; Name=2; IsoId=Q8C0M0-2; Sequence=VSP_023886; Name=3; IsoId=Q8C0M0-3; Sequence=VSP_023885, VSP_023886; Belongs to the WD repeat WDR59 family. Sequence=BAC30708.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32579.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE42108.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; molecular_function lysosome lysosomal membrane membrane positive regulation of TOR signaling cellular response to amino acid starvation GATOR2 complex uc009nmj.1 uc009nmj.2 uc009nmj.3 uc009nmj.4 
ENSMUST00000038196.7 Mks1 ENSMUST00000038196.7 MKS transition zone complex subunit 1 (from RefSeq NM_001039684.3) ENSMUST00000038196.1 ENSMUST00000038196.2 ENSMUST00000038196.3 ENSMUST00000038196.4 ENSMUST00000038196.5 ENSMUST00000038196.6 MKS1_MOUSE NM_001039684 Q3V3W3 Q5SW45 uc007kuu.1 uc007kuu.2 uc007kuu.3 Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Part of the tectonic-like complex (also named B9 complex) (PubMed:22179047, PubMed:21725307). Interacts with TMEM107 (By similarity). Interacts with TCTN3, AHI1, TCTN1, TCTN2, CC2D2A (PubMed:21565611). Interacts with FLNA. Interacts with TMEM67 (By similarity). Interacts with B9D1 and B9D2 (PubMed:21763481, PubMed:21565611). Q5SW45; Q9R1S0: B9d1; NbExp=4; IntAct=EBI-4281059, EBI-5652050; Q5SW45; Q3UK10: B9d2; NbExp=3; IntAct=EBI-4281059, EBI-5652008; Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Widely expressed in embryo at 15.5 dpc, with a relatively strong expression in brain, liver, kidney and digits of the upper limbs. Highly expressed in bronchiolar epithelium. neural tube closure smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation cardiac septum development protein binding cytoplasm centrosome centriole microtubule organizing center cytoskeleton cilium smoothened signaling pathway determination of left/right symmetry regulation of smoothened signaling pathway epithelial structure maintenance membrane cell projection organization ciliary transition zone MKS complex ciliary basal body embryonic digit morphogenesis cell projection motile cilium assembly embryonic skeletal system development branching morphogenesis of an epithelial tube inner ear receptor stereocilium organization cilium assembly head development cardiac septum morphogenesis regulation of canonical Wnt signaling pathway common bile duct development regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning non-motile cilium assembly embryonic brain development regulation of Wnt signaling pathway, planar cell polarity pathway uc007kuu.1 uc007kuu.2 uc007kuu.3 
ENSMUST00000038197.3 Mrap ENSMUST00000038197.3 melanocortin 2 receptor accessory protein, transcript variant 2 (from RefSeq NR_155757.1) ENSMUST00000038197.1 ENSMUST00000038197.2 Falp MRAP_MOUSE NR_155757 Q3TZ49 Q8R439 Q9D159 uc007zwl.1 uc007zwl.2 uc007zwl.3 Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity). Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP2. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R (By similarity). Cell membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha; IsoId=Q9D159-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q9D159-2; Sequence=VSP_003865, VSP_003866; Largely restricted to fat tissues. Predominantly expressed in mouse epididymal (white adipose tissue) and interscapular (brown adipose tissue) fat pads. Expression is weak or absent in lung, spleen, intestine, kidney, heart and skeletal muscle. Expressed during adipocyte differentiation. Expression appears 2 days following induction of adipose conversion, reaching a peak after 6 days. Belongs to the MRAP family. endoplasmic reticulum endoplasmic reticulum membrane plasma membrane membrane integral component of membrane corticotropin hormone receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding type 5 melanocortin receptor binding identical protein binding brown fat cell differentiation type 1 melanocortin receptor binding protein localization to plasma membrane negative regulation of protein localization to plasma membrane uc007zwl.1 uc007zwl.2 uc007zwl.3 
ENSMUST00000038211.13 Slfn9 ENSMUST00000038211.13 schlafen 9 (from RefSeq NM_172796.2) A0A0A0MQG6 B1ARD6 ENSMUST00000038211.1 ENSMUST00000038211.10 ENSMUST00000038211.11 ENSMUST00000038211.12 ENSMUST00000038211.2 ENSMUST00000038211.3 ENSMUST00000038211.4 ENSMUST00000038211.5 ENSMUST00000038211.6 ENSMUST00000038211.7 ENSMUST00000038211.8 ENSMUST00000038211.9 NM_172796 Q7TME8 Q7TME9 Q80VG8 Q8C7F7 Q8CB82 SLFN9_MOUSE Slfn9 uc007kob.1 uc007kob.2 uc007kob.3 Endoribonuclease that cleaves tRNAs and rRNAs. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Can also use Mn(2+). ; Cytoplasm In T-cells, expressed at relatively constant levels during development: expressed in immature CD3(-)CD4(-)CD8(-) T-cells (DN stage), in CD4(+)CD8(+) double-positive stage (DP) and mature CD4(+) or CD8(+) thymocytes. Expression is slightly reduced at the DP stage. Induced following infection. Induced in response to LPS and interferon. Shows a pseudo-dimeric U-pillow-shaped architecture of the SLFN13 N'-domain that may clamp base-paired RNAs. Belongs to the Schlafen family. Subgroup III subfamily. Sequence=AL603745; Type=Erroneous gene model prediction; Evidence=; tRNA binding nucleotide binding nuclease activity endonuclease activity endoribonuclease activity ATP binding nucleus cytoplasm zinc ion binding hydrolase activity metal ion binding defense response to virus nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc007kob.1 uc007kob.2 uc007kob.3 
ENSMUST00000038212.14 Gzmk ENSMUST00000038212.14 granzyme K (from RefSeq NM_008196.2) ENSMUST00000038212.1 ENSMUST00000038212.10 ENSMUST00000038212.11 ENSMUST00000038212.12 ENSMUST00000038212.13 ENSMUST00000038212.2 ENSMUST00000038212.3 ENSMUST00000038212.4 ENSMUST00000038212.5 ENSMUST00000038212.6 ENSMUST00000038212.7 ENSMUST00000038212.8 ENSMUST00000038212.9 GRAK_MOUSE NM_008196 O35205 uc007rxd.1 uc007rxd.2 uc007rxd.3 Cytoplasmic granule. Belongs to the peptidase S1 family. Granzyme subfamily. serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity positive regulation of apoptotic process negative regulation of oxidoreductase activity uc007rxd.1 uc007rxd.2 uc007rxd.3 
ENSMUST00000038217.14 Dtx3 ENSMUST00000038217.14 deltex 3, E3 ubiquitin ligase, transcript variant 1 (from RefSeq NM_030714.2) DTX3_MOUSE ENSMUST00000038217.1 ENSMUST00000038217.10 ENSMUST00000038217.11 ENSMUST00000038217.12 ENSMUST00000038217.13 ENSMUST00000038217.2 ENSMUST00000038217.3 ENSMUST00000038217.4 ENSMUST00000038217.5 ENSMUST00000038217.6 ENSMUST00000038217.7 ENSMUST00000038217.8 ENSMUST00000038217.9 NM_030714 Q4FZD3 Q80V91 Q9ER06 uc007hil.1 uc007hil.2 Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1. Cytoplasm Strongly expressed in testis and brain. Weakly expressed in kidney. In the CNS, it is expressed in the developing neural tube starting from 10.5 dpc in the spinal cord and around 11.5 dpc in the telencephalon. Expressed ubiquitously throughout the spinal cord and telencephalon during neurogenesis. Expressed throughout the developing retina at 15.5 dpc. Not expressed in the somite or presomite during somitogenesis. Expressed slightly later that Dtx2. Belongs to the Deltex family. cellular_component cytoplasm Notch signaling pathway protein ubiquitination transferase activity metal ion binding uc007hil.1 uc007hil.2 
ENSMUST00000038223.8 Zswim2 ENSMUST00000038223.8 zinc finger SWIM-type containing 2, transcript variant 1 (from RefSeq NM_027964.3) ENSMUST00000038223.1 ENSMUST00000038223.2 ENSMUST00000038223.3 ENSMUST00000038223.4 ENSMUST00000038223.5 ENSMUST00000038223.6 ENSMUST00000038223.7 NM_027964 Q9D9X6 ZSWM2_MOUSE uc008kif.1 uc008kif.2 E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Dimer. Interacts with UBE2D1. Expressed only in testis. The SWIM-type zinc finger is required for ubiquitination activity. Polyubiquitinated. Polyubiquitination is followed by degradation via the proteasome. protein polyubiquitination ubiquitin-protein transferase activity protein binding cellular_component apoptotic process zinc ion binding transferase activity protein self-association metal ion binding ubiquitin protein ligase activity positive regulation of extrinsic apoptotic signaling pathway via death domain receptors uc008kif.1 uc008kif.2 
ENSMUST00000038227.6 Ackr1 ENSMUST00000038227.6 atypical chemokine receptor 1 (Duffy blood group) (from RefSeq NM_010045.3) A0A0R4J0J4 A0A0R4J0J4_MOUSE Ackr1 ENSMUST00000038227.1 ENSMUST00000038227.2 ENSMUST00000038227.3 ENSMUST00000038227.4 ENSMUST00000038227.5 NM_010045 uc007drg.1 uc007drg.2 uc007drg.3 Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. Early endosome Membrane ulti-pass membrane protein Recycling endosome Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily. inflammatory response membrane integral component of membrane chemokine binding C-C chemokine binding chemokine-mediated signaling pathway uc007drg.1 uc007drg.2 uc007drg.3 
ENSMUST00000038228.11 Tmx4 ENSMUST00000038228.11 thioredoxin-related transmembrane protein 4 (from RefSeq NM_029148.1) D2Bwg1356e ENSMUST00000038228.1 ENSMUST00000038228.10 ENSMUST00000038228.2 ENSMUST00000038228.3 ENSMUST00000038228.4 ENSMUST00000038228.5 ENSMUST00000038228.6 ENSMUST00000038228.7 ENSMUST00000038228.8 ENSMUST00000038228.9 Kiaa1162 NM_029148 Q3UHC6 Q6ZPW7 Q80X49 Q8C0L0 TMX4_MOUSE Txndc13 uc008mnt.1 uc008mnt.2 uc008mnt.3 uc008mnt.4 uc008mnt.5 Nucleus inner membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Sequence=AAH50918.1; Type=Erroneous initiation; Evidence=; Sequence=BAC98111.1; Type=Erroneous initiation; Evidence=; nuclear inner membrane membrane integral component of membrane cell redox homeostasis oxidation-reduction process uc008mnt.1 uc008mnt.2 uc008mnt.3 uc008mnt.4 uc008mnt.5 
ENSMUST00000038229.5 Neil2 ENSMUST00000038229.5 nei like 2 (E. coli) (from RefSeq NM_201610.2) ENSMUST00000038229.1 ENSMUST00000038229.2 ENSMUST00000038229.3 ENSMUST00000038229.4 G3X969 Gm1212 NEIL2_MOUSE NM_201610 Q6R2P8 uc007uhk.1 uc007uhk.2 uc007uhk.3 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5- hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity). Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA- COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695, ChEBI:CHEBI:167181; EC=4.2.99.18; Evidence= Acetylation of Lys-50 leads to loss of DNA nicking activity. Binds EP300. Nucleus The zinc-finger domain is important for DNA binding. Belongs to the FPG family. nucleic acid binding DNA binding damaged DNA binding catalytic activity DNA-(apurinic or apyrimidinic site) lyase activity nucleus nucleoplasm cytoplasm DNA repair base-excision repair nucleotide-excision repair cellular response to DNA damage stimulus microtubule binding metabolic process zinc ion binding microtubule cytoskeleton hydrolase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing N-glycosyl compounds lyase activity DNA N-glycosylase activity intracellular membrane-bounded organelle metal ion binding spindle microtubule uc007uhk.1 uc007uhk.2 uc007uhk.3 
ENSMUST00000038237.8 Thoc5 ENSMUST00000038237.8 THO complex 5, transcript variant 1 (from RefSeq NM_172438.4) A0A0R4J0J6 A0A0R4J0J6_MOUSE ENSMUST00000038237.1 ENSMUST00000038237.2 ENSMUST00000038237.3 ENSMUST00000038237.4 ENSMUST00000038237.5 ENSMUST00000038237.6 ENSMUST00000038237.7 NM_172438 Thoc5 uc007hvl.1 uc007hvl.2 Nucleus Belongs to the THOC5 family. transcription export complex THO complex THO complex part of transcription export complex nuclear chromosome, telomeric region nucleus nucleoplasm mRNA export from nucleus monocyte differentiation positive regulation of DNA-templated transcription, elongation viral mRNA export from host cell nucleus negative regulation of DNA damage checkpoint uc007hvl.1 uc007hvl.2 
ENSMUST00000038244.15 Gpsm3 ENSMUST00000038244.15 G-protein signalling modulator 3 (AGS3-like, C. elegans) (from RefSeq NM_134116.5) ENSMUST00000038244.1 ENSMUST00000038244.10 ENSMUST00000038244.11 ENSMUST00000038244.12 ENSMUST00000038244.13 ENSMUST00000038244.14 ENSMUST00000038244.2 ENSMUST00000038244.3 ENSMUST00000038244.4 ENSMUST00000038244.5 ENSMUST00000038244.6 ENSMUST00000038244.7 ENSMUST00000038244.8 ENSMUST00000038244.9 GPSM3_MOUSE NM_134116 Q3U1M8 Q3U1Z5 Q3UJZ5 Q8VDF9 uc012aqd.1 uc012aqd.2 Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U1Z5-1; Sequence=Displayed; Name=2; IsoId=Q3U1Z5-2; Sequence=VSP_018153, VSP_018154; The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity towards GDP-bound G(i) alpha protein, but not the GoLoco 2 domain. Sequence=BAE27009.1; Type=Frameshift; Evidence=; positive regulation of leukocyte chemotaxis cytoplasm plasma membrane GTPase regulator activity positive regulation of inflammatory response regulation of catalytic activity positive regulation of cytokine production involved in inflammatory response uc012aqd.1 uc012aqd.2 
ENSMUST00000038252.4 B3galt2 ENSMUST00000038252.4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 (from RefSeq NM_020025.4) B3GT2_MOUSE B3galt2 ENSMUST00000038252.1 ENSMUST00000038252.2 ENSMUST00000038252.3 NM_020025 O54905 Q8BH19 Q8CBX4 Q91V19 Q91V58 Q91VE9 Q920V3 Q920V4 uc007cwy.1 uc007cwy.2 uc007cwy.3 uc007cwy.4 Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Reaction=an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D- galactose = a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:53432, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:61631, ChEBI:CHEBI:66914, ChEBI:CHEBI:133506; EC=2.4.1.86; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53433; Evidence=; Reaction=a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)- Cer(d18:1(4E)) + UDP-alpha-D-galactose = a beta-D-Gal-(1->3)-beta-D- GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:16045, ChEBI:CHEBI:15378, ChEBI:CHEBI:17103, ChEBI:CHEBI:17292, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914; EC=2.4.1.86; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16046; Evidence=; Reaction=a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP- alpha-D-galactose = a neolactoside IV(3)-beta-[Gal-beta-(1->3)- GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:41936, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:78565, ChEBI:CHEBI:142448; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41937; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Kinetic parameters: KM=0.6 mM for UDP-alpha-D-galactose ; KM=38.3 mM for GlcNAc-beta-pNP ; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Detected in brain and heart. Belongs to the glycosyltransferase 31 family. Name=Functional Glycomics Gateway - GTase; Note=b3GalT2; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_455"; Golgi membrane endoplasmic reticulum Golgi apparatus protein glycosylation protein N-linked glycosylation protein O-linked glycosylation galactosylceramide biosynthetic process acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity oligosaccharide biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity uc007cwy.1 uc007cwy.2 uc007cwy.3 uc007cwy.4 
ENSMUST00000038259.13 Slco4a1 ENSMUST00000038259.13 solute carrier organic anion transporter family, member 4a1, transcript variant 2 (from RefSeq NM_001355218.1) ENSMUST00000038259.1 ENSMUST00000038259.10 ENSMUST00000038259.11 ENSMUST00000038259.12 ENSMUST00000038259.2 ENSMUST00000038259.3 ENSMUST00000038259.4 ENSMUST00000038259.5 ENSMUST00000038259.6 ENSMUST00000038259.7 ENSMUST00000038259.8 ENSMUST00000038259.9 NM_001355218 Oatp4a1 Oatpe Q8BZT4 Q8K078 SO4A1_MOUSE Slc21a12 uc008ojc.1 uc008ojc.2 uc008ojc.3 uc008ojc.4 uc008ojc.5 Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo- L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue- specific manner (By similarity). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (By similarity). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). Reaction=3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) = 3,3',5- triiodo-L-thyronine(in) + L-glutamate(out); Xref=Rhea:RHEA:72299, ChEBI:CHEBI:29985, ChEBI:CHEBI:533015; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72300; Evidence=; Reaction=L-glutamate(in) + L-thyroxine(out) = L-glutamate(out) + L- thyroxine(in); Xref=Rhea:RHEA:72303, ChEBI:CHEBI:29985, ChEBI:CHEBI:58448; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72304; Evidence=; Reaction=estrone 3-sulfate(out) + L-glutamate(in) = estrone 3- sulfate(in) + L-glutamate(out); Xref=Rhea:RHEA:72239, ChEBI:CHEBI:29985, ChEBI:CHEBI:60050; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72240; Evidence=; Reaction=L-glutamate(in) + taurocholate(out) = L-glutamate(out) + taurocholate(in); Xref=Rhea:RHEA:72307, ChEBI:CHEBI:29985, ChEBI:CHEBI:36257; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72308; Evidence=; Reaction=3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L- thyronine(in); Xref=Rhea:RHEA:71811, ChEBI:CHEBI:533015; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71812; Evidence=; Reaction=L-thyroxine(out) = L-thyroxine(in); Xref=Rhea:RHEA:71819, ChEBI:CHEBI:58448; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71820; Evidence=; Reaction=3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L- thyronine(in); Xref=Rhea:RHEA:71815, ChEBI:CHEBI:57261; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71816; Evidence=; Reaction=estrone 3-sulfate(out) = estrone 3-sulfate(in); Xref=Rhea:RHEA:71835, ChEBI:CHEBI:60050; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71836; Evidence=; Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(out) = 17beta- estradiol 17-O-(beta-D-glucuronate)(in); Xref=Rhea:RHEA:72691, ChEBI:CHEBI:82961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72692; Evidence=; Reaction=taurocholate(out) = taurocholate(in); Xref=Rhea:RHEA:71703, ChEBI:CHEBI:36257; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71704; Evidence=; Reaction=prostaglandin E2(out) = prostaglandin E2(in); Xref=Rhea:RHEA:50984, ChEBI:CHEBI:606564; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50985; Evidence=; Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K078-1; Sequence=Displayed; Name=2; IsoId=Q8K078-2; Sequence=VSP_006157, VSP_006158; A conserved histidine residue in the third TMD (His-190) may play an essential role in the pH sensitivity of SLCO4A1/OATP4A1- mediated substrate transport. Belongs to the organo anion transporter (TC 2.A.60) family. Sequence=AAH33602.1; Type=Erroneous initiation; Evidence=; plasma membrane integral component of plasma membrane ion transport organic anion transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity thyroid hormone transmembrane transporter activity organic anion transport membrane integral component of membrane thyroid hormone metabolic process sodium-independent organic anion transport transmembrane transport thyroid hormone transport uc008ojc.1 uc008ojc.2 uc008ojc.3 uc008ojc.4 uc008ojc.5 
ENSMUST00000038275.11 Mylip ENSMUST00000038275.11 myosin regulatory light chain interacting protein (from RefSeq NM_153789.3) ENSMUST00000038275.1 ENSMUST00000038275.10 ENSMUST00000038275.2 ENSMUST00000038275.3 ENSMUST00000038275.4 ENSMUST00000038275.5 ENSMUST00000038275.6 ENSMUST00000038275.7 ENSMUST00000038275.8 ENSMUST00000038275.9 MYLIP_MOUSE NM_153789 Q3TX01 Q8BLY9 Q8BM54 Q91Z47 uc007qgz.1 uc007qgz.2 uc007qgz.3 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Can bind 1 iron ion per dimer. Iron binding seems to decrease LDLR degradation activity. Protein modification; protein ubiquitination. Homodimer. Interacts with the E2 ubiquitin-conjugating enzyme, UBE2D1 (via RING-type zinc finger). Interacts with myosin regulatory light chain (MRLC) and TMEM4. Cytoplasm Cell membrane ; Peripheral membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BM54-1; Sequence=Displayed; Name=2; IsoId=Q8BM54-2; Sequence=VSP_011830; Expressed in liver, spleen, intestine and adrenals. The RING domain mediates ubiquitination and the neurite outgrowth inhibitory activity. The FERM domain binds phospholipids and mediates lipoprotein receptors recognition at the plasma membrane through their cytoplasmic tails. The RING-type zinc finger mediates the interaction with UBE2D E2 enzymes. Autoubiquitinated. ubiquitin-protein transferase activity cytoplasm cytoskeleton plasma membrane ubiquitin-dependent protein catabolic process nervous system development cytoskeletal protein binding negative regulation of neuron projection development negative regulation of low-density lipoprotein particle clearance membrane protein ubiquitination transferase activity protein destabilization regulation of low-density lipoprotein particle receptor catabolic process cholesterol homeostasis positive regulation of protein catabolic process metal ion binding ubiquitin protein ligase activity cellular response to low-density lipoprotein particle stimulus uc007qgz.1 uc007qgz.2 uc007qgz.3 
ENSMUST00000038280.5 Fermt1 ENSMUST00000038280.5 fermitin family member 1 (from RefSeq NM_198029.2) A2ANX1 ENSMUST00000038280.1 ENSMUST00000038280.2 ENSMUST00000038280.3 ENSMUST00000038280.4 FERM1_MOUSE Kind1 NM_198029 P59113 Q8BQG6 Urp1 uc008mno.1 uc008mno.2 uc008mno.3 Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites (By similarity). Interacts with the cytoplasmic domain of integrins ITGB1 and ITGB3. Cytoplasm, cytoskeleton Cell junction, focal adhesion Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Colocalizes with filamentous actin. Constituent of focal adhesions (By similarity). Localized at the basal aspect of skin keratinocytes, close to the cell membrane (By similarity). Upon TGFB1 treatment, it localizes to membrane ruffles (By similarity). The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. The FERM domain contains the subdomains F1, F2 and F3. It is preceded by a F0 domain with a ubiquitin-like fold. The F0 domain is required for integrin activation and for localization at focal adhesions (By similarity). Mice are born with the expected Mendelian distribution and appear normal at birth, but fail to thrive, become dehydrated and die after three to five days. They develop skin atrophy and die due to a lethal intestinal epithelial dysfunction. The colon is shortened and swollen and presents signs of acute inflammation. At the time of death, about 80% of the colonic epithelium is detached. Belongs to the kindlin family. Sequence=AAH29093.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; positive regulation of cell-matrix adhesion cytoplasm cytosol cytoskeleton plasma membrane focal adhesion cell adhesion integrin-mediated signaling pathway negative regulation of gene expression membrane cell junction positive regulation of transforming growth factor beta receptor signaling pathway ruffle membrane positive regulation of cell adhesion mediated by integrin negative regulation of protein import into nucleus cell projection keratinocyte proliferation actin filament binding keratinocyte migration negative regulation of anagen basement membrane organization negative regulation of canonical Wnt signaling pathway establishment of epithelial cell polarity negative regulation of stem cell proliferation positive regulation of transforming growth factor-beta secretion uc008mno.1 uc008mno.2 uc008mno.3 
ENSMUST00000038287.7 Dusp5 ENSMUST00000038287.7 dual specificity phosphatase 5 (from RefSeq NM_001085390.2) Dusp5 ENSMUST00000038287.1 ENSMUST00000038287.2 ENSMUST00000038287.3 ENSMUST00000038287.4 ENSMUST00000038287.5 ENSMUST00000038287.6 NM_001085390 Q1HL35 Q1HL35_MOUSE uc008hwx.1 uc008hwx.2 uc008hwx.3 Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Nucleus Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. inactivation of MAPK activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity peptidyl-tyrosine dephosphorylation peptidyl-threonine dephosphorylation negative regulation of transcription, DNA-templated negative regulation of vasoconstriction uc008hwx.1 uc008hwx.2 uc008hwx.3 
ENSMUST00000038332.9 Ctu1 ENSMUST00000038332.9 cytosolic thiouridylase subunit 1 (from RefSeq NM_145582.1) Atpbd3 CTU1_MOUSE ENSMUST00000038332.1 ENSMUST00000038332.2 ENSMUST00000038332.3 ENSMUST00000038332.4 ENSMUST00000038332.5 ENSMUST00000038332.6 ENSMUST00000038332.7 ENSMUST00000038332.8 NM_145582 Ncs6 Q99J10 uc009gnh.1 uc009gnh.2 uc009gnh.3 uc009gnh.4 Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2. Cytoplasm Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily. tRNA binding tRNA wobble uridine modification tRNA wobble position uridine thiolation cytosolic tRNA wobble base thiouridylase complex RNA binding cytoplasm mitochondrion cytosol tRNA processing transferase activity nucleotidyltransferase activity protein urmylation tRNA thio-modification uc009gnh.1 uc009gnh.2 uc009gnh.3 uc009gnh.4 
ENSMUST00000038341.8 Bub1b ENSMUST00000038341.8 BUB1B, mitotic checkpoint serine/threonine kinase (from RefSeq NM_009773.3) A2ARS1 BUB1B_MOUSE ENSMUST00000038341.1 ENSMUST00000038341.2 ENSMUST00000038341.3 ENSMUST00000038341.4 ENSMUST00000038341.5 ENSMUST00000038341.6 ENSMUST00000038341.7 Mad3l NM_009773 Q9Z1S0 uc008lse.1 uc008lse.2 uc008lse.3 uc008lse.4 Essential component of the mitotic checkpoint. Required for normal mitosis progression and tumor suppression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. Essential for tumor suppression. May play a role in regulating aging and fertility (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Kinase activity stimulated by CENPE. Interacts with CENPE (PubMed:12925705). Interacts with PLK1 (By similarity). Part of a complex containing BUB3, CDC20 and BUB1B (By similarity). Interacts with anaphase-promoting complex/cyclosome (APC/C) (By similarity). Interacts with KNL1 (By similarity). Interacts with KAT2B (By similarity). Interacts with RIPK3 (By similarity). Interacts with the closed conformation form of MAD2L1 (By similarity). Interacts with CDC20 (By similarity). Cytoplasm Nucleus Chromosome, centromere, kinetochore te=Cytoplasmic in interphase cells (By similarity). Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and KNL1 (By similarity). Highly expressed in thymus followed by spleen. The D-box targets the protein for rapid degradation by ubiquitin-dependent proteolysis during the transition from mitosis to interphase. The BUB1 N-terminal domain directs kinetochore localization and binding to BUB3. Proteolytically cleaved by caspase-3 in a cell cycle specific manner. The cleavage might be involved in the durability of the cell cycle delay. Acetylation at Lys-243 regulates its degradation and timing in anaphase entry. Ubiquitinated. Degraded by the proteasome (By similarity). Sumoylated with SUMO2 and SUMO3. The sumoylation mediates the association with CENPE at the kinetochore (By similarity). Autophosphorylated in vitro. Intramolecular autophosphorylation stimulated by CENPE. Phosphorylated during mitosis and hyperphosphorylated in mitotically arrested cells. Phosphorylation at Ser-659 and Ser-1033 occurs at kinetochores upon mitotic entry with dephosphorylation at the onset of anaphase. Note=Defects in Bub1b are involved in the development of lung and intestinal adenocarcinomas after exposure to a carcinogen. Mice die in utero. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily. nucleotide binding chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed nuclear chromosome kinetochore condensed chromosome outer kinetochore protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus chromosome cytoplasm spindle cytosol protein phosphorylation apoptotic process cell cycle metaphase/anaphase transition of mitotic cell cycle mitotic spindle assembly checkpoint kinase activity phosphorylation transferase activity perinuclear region of cytoplasm cell division meiotic sister chromatid cohesion, centromeric protein localization to chromosome, centromeric region uc008lse.1 uc008lse.2 uc008lse.3 uc008lse.4 
ENSMUST00000038343.7 B4galnt2 ENSMUST00000038343.7 beta-1,4-N-acetyl-galactosaminyl transferase 2 (from RefSeq NM_008081.3) B4GN2_MOUSE ENSMUST00000038343.1 ENSMUST00000038343.2 ENSMUST00000038343.3 ENSMUST00000038343.4 ENSMUST00000038343.5 ENSMUST00000038343.6 Galgt2 Ggm3 NM_008081 Q09199 uc007lax.1 uc007lax.2 uc007lax.3 Responsible for synthesis of murine T-lymphocyte CT antigen. Can transfer N-acetylgalactosamine moiety from UDP-GalNAc to the low molecular weight acceptor 3'-sialyl-N-acetyllactosamine, to form a non- reducing terminal tetrasaccharide Sda blood group structure. Protein modification; protein glycosylation. Golgi apparatus membrane; Single-pass type II membrane protein. Belongs to the glycosyltransferase 2 family. Golgi membrane Golgi apparatus UDP-N-acetylglucosamine metabolic process protein glycosylation acetylgalactosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups UDP-N-acetylgalactosamine metabolic process negative regulation of cell-cell adhesion integral component of Golgi membrane lipid glycosylation uc007lax.1 uc007lax.2 uc007lax.3 
ENSMUST00000038356.13 Ube2q1 ENSMUST00000038356.13 ubiquitin-conjugating enzyme E2Q family member 1 (from RefSeq NM_027315.4) ENSMUST00000038356.1 ENSMUST00000038356.10 ENSMUST00000038356.11 ENSMUST00000038356.12 ENSMUST00000038356.2 ENSMUST00000038356.3 ENSMUST00000038356.4 ENSMUST00000038356.5 ENSMUST00000038356.6 ENSMUST00000038356.7 ENSMUST00000038356.8 ENSMUST00000038356.9 NM_027315 Q29ST1 Q3UIY3 Q6P913 Q7TSS2 Q80UT5 Q8K2T0 Q9D7E1 UB2Q1_MOUSE Ube2q uc008qad.1 uc008qad.2 uc008qad.3 uc008qad.4 Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Involved in female fertility and embryo implantation (PubMed:23108111). May be involved in hormonal homeostasis in females (PubMed:23108111). Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (PubMed:18511602). Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence=; Protein modification; protein ubiquitination. Monomer and homodimer. Only the homodimer is linked to ubiquitin through thiolester activation. Interacts (via N-terminus) with B4GALT1 (via N-terminal cytoplasmic domain); the interaction is direct. Nucleus Cell projection, filopodium Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TSS2-1; Sequence=Displayed; Name=2; IsoId=Q7TSS2-2; Sequence=VSP_017297; Expressed in liver, brain, heart, spleen, lung, kidney, muscle, ovary, epididymis, testis and placenta (PubMed:23108111). Also expressed in thymus and ES cells (PubMed:18511602). Only expressed in the uterus during pregnancy (PubMed:23108111). Expressed in oocytes and during subsequent embryonic development stages (4-cell stage, blastocyst, 8.5 dpc, 13.5 dpc, 16.5 dpc and 18.5 dpc) (PubMed:23108111). Autoubiquitinated in vitro in the presence of NEDD4L. No reproductive defects in males but females have reduced litter size due to embryo implantation failure, normal ovulation but a longer estrus cycle, reduced levels of serum prolactin at the beginning of lactation, abnormal sexual behavior and show reduced offspring care. Belongs to the ubiquitin-conjugating enzyme family. Sequence=AAH51487.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB26217.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding suckling behavior ATP binding nucleus cytoplasm cytosol embryo implantation mating behavior fertilization protein ubiquitination transferase activity filopodium cell projection reproductive system development ubiquitin conjugating enzyme activity prolactin secretion uc008qad.1 uc008qad.2 uc008qad.3 uc008qad.4 
ENSMUST00000038361.11 Mgat5 ENSMUST00000038361.11 mannoside acetylglucosaminyltransferase 5 (from RefSeq NM_145128.3) ENSMUST00000038361.1 ENSMUST00000038361.10 ENSMUST00000038361.2 ENSMUST00000038361.3 ENSMUST00000038361.4 ENSMUST00000038361.5 ENSMUST00000038361.6 ENSMUST00000038361.7 ENSMUST00000038361.8 ENSMUST00000038361.9 MGT5A_MOUSE NM_145128 Q8R4G6 uc007ckt.1 uc007ckt.2 uc007ckt.3 uc007ckt.4 uc007ckt.5 Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:10700233, PubMed:14561752, PubMed:22715095). Catalyzes an important step in the biosynthesis of branched, complex- type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2 (PubMed:12122020, PubMed:10700233, PubMed:14561752, PubMed:15459394, PubMed:22715095). Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration (PubMed:10700233, PubMed:14561752, PubMed:15459394). MGAT5-dependent EGFR N-glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling (PubMed:15459394). Required for efficient interaction between TGFB1 and its receptor (PubMed:15459394). Enhances activation of intracellular signaling pathways by several types of growth factors, including FGF2, PDGF, IGF, TGFB1 and EGF (PubMed:15459394). MGAT5-dependent CDH2 N-glycosylation inhibits CDH2-mediated homotypic cell-cell adhesion and contributes to the regulation of downstream signaling pathways (PubMed:14561752). Promotes cell migration (PubMed:14561752, PubMed:15459394). Contributes to the regulation of the inflammatory response (PubMed:11217864, PubMed:15459394). MGAT5-dependent TCR N-glycosylation enhances the interaction between TCR and LGALS3, limits agonist-induced TCR clustering, and thereby dampens TCR-mediated responses to antigens (PubMed:11217864). Required for normal leukocyte evasation and accumulation at sites of inflammation (PubMed:15459394). Inhibits attachment of monocytes to the vascular endothelium and subsequent monocyte diapedesis (By similarity). [Secreted alpha-1,6-mannosylglycoprotein 6-beta-N- acetylglucosaminyltransferase A]: Promotes proliferation of umbilical vein endothelial cells and angiogenesis, at least in part by promoting the release of the growth factor FGF2 from the extracellular matrix. Reaction=N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man- (1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N- acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta- D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D- GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc- (1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:16921, Rhea:RHEA-COMP:14374, Rhea:RHEA-COMP:14377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:139507, ChEBI:CHEBI:139510; EC=2.4.1.155; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein Perikaryon [Secreted alpha-1,6-mannosylglycoprotein 6-beta- N-acetylglucosaminyltransferase A]: Secreted Detected in cerebellum. N-glycosylated. A secreted form is released from the membrane after cleavage by gamma-secretase. Mice are born at the expected Mendelian rate and have no visible phenotype at birth. Adult mice display abnormal leukocyte recruitment to inflamed tissues, hypersensitivity of T cells to agonists that activate T cell receptors, an age-related decrease in the cellularity of kidney glomeruli and a tendency to develop proliferative glomerulonephritis, plus defective nurturing behavior (PubMed:10700233, PubMed:11217864). Mutant mice show increased responsiveness to treatments that cause delayed-type hypersensitivity (PubMed:11217864). Mice show increased incidence of autoimmune encephalomyelitis in response to injections with MBP (PubMed:11217864). Transgenic mice that express polyomavirus middle T antigen develop mammary tumors; 50% of female wild-type mice have detectable tumors after 16 weeks, but it takes 24 weeks until 50% of the female mice that lack Mgat5 develop mammary tumors. Male mice that express polyomavirus middle T antigen develop mammary tumors after 6 to 9 months; males that lack Mgat5 develop tumors after 10 to 13 months. Formation of lung metastases is about 5% of wild-type (PubMed:10700233). Tumor initiation is not decreased in mice that lack Mgat5, but tumor growth is strongly decreased (PubMed:10700233). Tumor cells from mutant mice show impaired membrane ruffling, probably due to decreased activation of phosphoinositide-3-kinase (PI3K) (PubMed:10700233). Embryonic fibroblasts from Mgat5-deficient mice display increased Cdh2-mediated cell-cell adhesion (PubMed:14561752). Mutant mice that lack both Mgat5 and Mgat5b display no visible changes in brain anatomy, but their brains display defective biosynthesis of both O-mannosyl glycans and N- linked glycans (PubMed:22715095). Belongs to the glycosyltransferase 18 family. Golgi membrane protein phosphatase inhibitor activity extracellular region Golgi apparatus protein glycosylation protein N-linked glycosylation acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein N-linked glycosylation via asparagine alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity manganese ion binding positive regulation of cell migration perikaryon negative regulation of protein tyrosine phosphatase activity positive regulation of STAT cascade uc007ckt.1 uc007ckt.2 uc007ckt.3 uc007ckt.4 uc007ckt.5 
ENSMUST00000038364.15 Fstl5 ENSMUST00000038364.15 follistatin-like 5, transcript variant 1 (from RefSeq NM_178673.4) ENSMUST00000038364.1 ENSMUST00000038364.10 ENSMUST00000038364.11 ENSMUST00000038364.12 ENSMUST00000038364.13 ENSMUST00000038364.14 ENSMUST00000038364.2 ENSMUST00000038364.3 ENSMUST00000038364.4 ENSMUST00000038364.5 ENSMUST00000038364.6 ENSMUST00000038364.7 ENSMUST00000038364.8 ENSMUST00000038364.9 FSTL5_MOUSE Kiaa1263 NM_178673 Q80TG3 Q8BFR2 Q8C4T3 uc008pnj.1 uc008pnj.2 uc008pnj.3 uc008pnj.4 Secreted calcium ion binding extracellular region multicellular organism development cell differentiation metal ion binding uc008pnj.1 uc008pnj.2 uc008pnj.3 uc008pnj.4 
ENSMUST00000038368.9 Id1 ENSMUST00000038368.9 inhibitor of DNA binding 1, HLH protein, transcript variant 2 (from RefSeq NM_010495.3) ENSMUST00000038368.1 ENSMUST00000038368.2 ENSMUST00000038368.3 ENSMUST00000038368.4 ENSMUST00000038368.5 ENSMUST00000038368.6 ENSMUST00000038368.7 ENSMUST00000038368.8 Id1 Idb1 NM_010495 Q6GTZ3 Q6GTZ3_MOUSE uc008ngf.1 uc008ngf.2 uc008ngf.3 Nucleus negative regulation of transcription from RNA polymerase II promoter nucleus nucleoplasm cytoplasm Golgi apparatus centrosome brain development protein C-terminus binding transcription factor binding positive regulation of gene expression response to organic cyclic compound neuron differentiation negative regulation of protein binding positive regulation of actin filament bundle assembly cell-abiotic substrate adhesion protein homodimerization activity negative regulation of apoptotic process negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of endothelial cell differentiation negative regulation of transcription, DNA-templated protein dimerization activity protein N-terminus binding positive regulation of epithelial cell proliferation negative regulation of dendrite morphogenesis proteasome binding cellular response to epidermal growth factor stimulus cellular response to transforming growth factor beta stimulus regulation of vasculature development cellular response to peptide cellular response to dopamine cellular response to nerve growth factor stimulus uc008ngf.1 uc008ngf.2 uc008ngf.3 
ENSMUST00000038374.13 Pcca ENSMUST00000038374.13 propionyl-Coenzyme A carboxylase, alpha polypeptide, transcript variant 9 (from RefSeq NR_189332.1) ENSMUST00000038374.1 ENSMUST00000038374.10 ENSMUST00000038374.11 ENSMUST00000038374.12 ENSMUST00000038374.2 ENSMUST00000038374.3 ENSMUST00000038374.4 ENSMUST00000038374.5 ENSMUST00000038374.6 ENSMUST00000038374.7 ENSMUST00000038374.8 ENSMUST00000038374.9 NR_189332 PCCA_MOUSE Pcca Q80VU5 Q91ZA3 Q922N3 uc007vbe.1 uc007vbe.2 uc007vbe.3 uc007vbe.4 This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl- CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)- ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). Reaction=ATP + hydrogencarbonate + propanoyl-CoA = (S)-methylmalonyl- CoA + ADP + H(+) + phosphate; Xref=Rhea:RHEA:23720, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57327, ChEBI:CHEBI:57392, ChEBI:CHEBI:456216; EC=6.4.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23721; Evidence=; Reaction=ATP + butanoyl-CoA + hydrogencarbonate = (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate; Xref=Rhea:RHEA:59520, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57371, ChEBI:CHEBI:60909, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59521; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit. ; Name=biotin; Xref=ChEBI:CHEBI:57586; Evidence=; Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3. The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits (By similarity). Interacts (via the biotin carboxylation domain) with SIRT4 (PubMed:23438705). Interacts with SIRT3 and SIRT5 (PubMed:23438705). Mitochondrion matrix Consists of an N-terminal biotin carboxylation/carboxylase (BC) domain that catalyzes the transient carboxylation of the biotin covalently attached to the C-terminal biotinyl-binding/biotin carboxyl carrier (BCC) domain. Acetylated. The biotin cofactor is covalently attached to the C-terminal biotinyl-binding domain and is required for the catalytic activity. Biotinylation is catalyzed by HLCS. Note=Propionic acidemia due to recessively inherited deficiency of PCCase activity often causes life-threatening ketosis and acidosis. nucleotide binding propionyl-CoA carboxylase activity ATP binding mitochondrion mitochondrial matrix ligase activity enzyme binding metal ion binding uc007vbe.1 uc007vbe.2 uc007vbe.3 uc007vbe.4 
ENSMUST00000038377.9 Btg1 ENSMUST00000038377.9 BTG anti-proliferation factor 1 (from RefSeq NM_007569.2) Btg1 ENSMUST00000038377.1 ENSMUST00000038377.2 ENSMUST00000038377.3 ENSMUST00000038377.4 ENSMUST00000038377.5 ENSMUST00000038377.6 ENSMUST00000038377.7 ENSMUST00000038377.8 NM_007569 Q3UEG0 Q3UEG0_MOUSE uc007gww.1 uc007gww.2 uc007gww.3 uc007gww.4 uc007gww.5 Anti-proliferative protein. Belongs to the BTG family. nucleus cytoplasm response to oxidative stress spermatogenesis negative regulation of cell proliferation enzyme binding response to peptide hormone positive regulation of endothelial cell differentiation positive regulation of myoblast differentiation positive regulation of angiogenesis positive regulation of fibroblast apoptotic process uc007gww.1 uc007gww.2 uc007gww.3 uc007gww.4 uc007gww.5 
ENSMUST00000038379.5 Cpsf7 ENSMUST00000038379.5 cleavage and polyadenylation specific factor 7, transcript variant 1 (from RefSeq NM_172302.4) CPSF7_MOUSE Cpsf7 ENSMUST00000038379.1 ENSMUST00000038379.2 ENSMUST00000038379.3 ENSMUST00000038379.4 NM_172302 Q3TNF1 Q8BKE7 Q8BTV2 Q8CFS8 uc008gpy.1 uc008gpy.2 uc008gpy.3 uc008gpy.4 Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA- 3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates. Component of the cleavage factor Im (CFIm) complex which is a heterotetramer composed of two subunits of NUDT21/CPSF5 and two subunits of CPSF6 or CPSF7 or a heterodimer of CPSF6 and CPSF7. The cleavage factor Im (CFIm) complex associates with the CPSF and CSTF complexes to promote the assembly of the core mRNA 3'-processing machinery. Interacts with NUDT21/CPSF5. Interacts (via Arg/Ser-rich domain) with FIP1L1 (preferentially via unphosphorylated form and Arg/Glu/Asp-rich region); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF7 hyper-phosphorylation. Nucleus Cytoplasm Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BTV2-1; Sequence=Displayed; Name=2; IsoId=Q8BTV2-2; Sequence=VSP_017196; Name=3; IsoId=Q8BTV2-3; Sequence=VSP_017195; Contains an Arg/Ser-rich domain composed of arginine-serine dipeptide repeats within the C-terminal region that is necessary and sufficient for activating mRNA 3'-processing. Phosphorylated. Asymmetrically dimethylated on arginine residues by PRMT1. Belongs to the RRM CPSF6/7 family. nucleic acid binding RNA binding nucleus cytoplasm mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex mRNA processing protein tetramerization protein heterotetramerization pre-mRNA cleavage required for polyadenylation messenger ribonucleoprotein complex assembly uc008gpy.1 uc008gpy.2 uc008gpy.3 uc008gpy.4 
ENSMUST00000038382.5 Jph1 ENSMUST00000038382.5 junctophilin 1 (from RefSeq NM_020604.2) ENSMUST00000038382.1 ENSMUST00000038382.2 ENSMUST00000038382.3 ENSMUST00000038382.4 JPH1_MOUSE Jp1 NM_020604 Q0VB08 Q9EQZ3 Q9ET80 uc007aka.1 uc007aka.2 uc007aka.3 uc007aka.4 Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N- terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands. Specifically expressed in skeletal muscle. Weakly expressed in embryos and neonates. Abundant in young adult muscles. The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids. Mice are unable to suckle probably due to defective E-C coupling in jaw muscles, and die shortly after birth. In skeletal muscles, triad junctions are reduced in number. Mutant mice developed less contractile force and abnormal sensitivities to extracellular Ca(2+) were observed. Sarcoplasmic reticulum is often structurally abnormal. Belongs to the junctophilin family. nucleus nucleoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane muscle organ development structural constituent of muscle junctional sarcoplasmic reticulum membrane calcium-release channel activity membrane integral component of membrane sarcoplasmic reticulum Z disc junctional membrane complex sarcoplasmic reticulum membrane release of sequestered calcium ion into cytosol uc007aka.1 uc007aka.2 uc007aka.3 uc007aka.4 
ENSMUST00000038383.14 Akr1b10 ENSMUST00000038383.14 aldo-keto reductase family 1, member B10, transcript variant 1 (from RefSeq NM_172398.3) Akr1b10 ENSMUST00000038383.1 ENSMUST00000038383.10 ENSMUST00000038383.11 ENSMUST00000038383.12 ENSMUST00000038383.13 ENSMUST00000038383.2 ENSMUST00000038383.3 ENSMUST00000038383.4 ENSMUST00000038383.5 ENSMUST00000038383.6 ENSMUST00000038383.7 ENSMUST00000038383.8 ENSMUST00000038383.9 G5E895 G5E895_MOUSE NM_172398 uc009bhb.1 uc009bhb.2 uc009bhb.3 Belongs to the aldo/keto reductase family. alditol:NADP+ 1-oxidoreductase activity mitochondrion cytosol alcohol dehydrogenase (NADP+) activity oxidoreductase activity retinal binding retinol metabolic process NADP-retinol dehydrogenase activity oxidation-reduction process NADP+ binding NADPH binding uc009bhb.1 uc009bhb.2 uc009bhb.3 
ENSMUST00000038384.8 Ythdc1 ENSMUST00000038384.8 YTH domain containing 1, transcript variant 1 (from RefSeq NM_177680.4) E9PW44 E9Q5K9 E9Q7Z8 ENSMUST00000038384.1 ENSMUST00000038384.2 ENSMUST00000038384.3 ENSMUST00000038384.4 ENSMUST00000038384.5 ENSMUST00000038384.6 ENSMUST00000038384.7 Kiaa1966 NM_177680 Q69Z54 Q80V25 Q8R5E6 YTDC1_MOUSE Ythdc1 uc008xxw.1 uc008xxw.2 uc008xxw.3 Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:29262316, PubMed:29799838). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:29799838). Acts as a key regulator of exon-inclusion or exon- skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (By similarity). Specifically binds m6A- containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (By similarity). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (By similarity). May also regulate alternative splice site selection (By similarity). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (By similarity). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (PubMed:29262316). Also recognizes and binds m6A on other RNA molecules (By similarity). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (By similarity). Also recognizes and binds m6A-containing single-stranded DNA (By similarity). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (PubMed:29799838). Interacts with SRSF1. Interacts with SRSF2 (By similarity). Interacts with SRSF3 (PubMed:29799838). Interacts with SRSF7 (PubMed:29799838). Interacts with SRSF10 (By similarity). Interacts with CPSF6 (PubMed:29799838). Interacts with KHDRBS1/SAM68.: Interacts with TRA2B. Interacts with KHDRBS3 (By similarity). Interacts with EMD (By similarity). Interacts with RBMX (By similarity). Interacts with ZCCHC8 (By similarity). E9Q5K9; O88974: Setdb1; NbExp=2; IntAct=EBI-647644, EBI-79658; Nucleus Nucleus speckle Note=Localizes to a novel subnuclear structure, the YT bodies. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=E9Q5K9-1; Sequence=Displayed; Name=2; IsoId=E9Q5K9-2; Sequence=VSP_053720; Name=3; IsoId=E9Q5K9-3; Sequence=VSP_053719, VSP_053720; The YTH domain mediates RNA-binding. Tyrosine phosphorylated. Embryonic lethality (PubMed:29799838). Conditional deletion in germ cells leads to infertility in both males and females: mice are viable and grossly normal but male mice lack any germ cells including mitotic spermatogonia, while female oocyte maturation is arrested at the primary follicle stage (PubMed:29799838). Ythdc1-deficient oocytes contain large cytoplasmic RNA granules, show extensive alternative polyadenylation, thereby altering 3'-UTR length, and massive alternative splicing defects (PubMed:29799838). Sequence=AAH48817.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome male germ cell nucleus RNA binding nucleus nucleoplasm plasma membrane mRNA splice site selection mRNA processing mRNA export from nucleus spermatogenesis RNA splicing dosage compensation by inactivation of X chromosome posttranscriptional regulation of gene expression nuclear body nuclear speck regulation of mRNA splicing, via spliceosome primary follicle stage N6-methyladenosine-containing RNA binding uc008xxw.1 uc008xxw.2 uc008xxw.3 
ENSMUST00000038388.7 Washc4 ENSMUST00000038388.7 WASH complex subunit 4 (from RefSeq NM_001033375.2) ENSMUST00000038388.1 ENSMUST00000038388.2 ENSMUST00000038388.3 ENSMUST00000038388.4 ENSMUST00000038388.5 ENSMUST00000038388.6 Kiaa1033 NM_001033375 Q3TTQ9 Q3UMB9 Q6ZPZ7 Q8CAK8 Q8CGK0 WASC4_MOUSE Washc4 uc007gkj.1 uc007gkj.2 Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASH (WASHC1, WASH2P or WASH3P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. The WASH core complex associates via WASHC2 with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex (By similarity). Early endosome Belongs to the SWIP family. Sequence=AAH20314.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH20314.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAE36266.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleoplasm endosome early endosome endosome organization protein transport endosomal transport WASH complex BLOC-1 complex uc007gkj.1 uc007gkj.2 
ENSMUST00000038389.15 Strc ENSMUST00000038389.15 stereocilin (from RefSeq NM_080459.2) A2ARP7 ENSMUST00000038389.1 ENSMUST00000038389.10 ENSMUST00000038389.11 ENSMUST00000038389.12 ENSMUST00000038389.13 ENSMUST00000038389.14 ENSMUST00000038389.2 ENSMUST00000038389.3 ENSMUST00000038389.4 ENSMUST00000038389.5 ENSMUST00000038389.6 ENSMUST00000038389.7 ENSMUST00000038389.8 ENSMUST00000038389.9 NM_080459 Q8VIM6 STRC_MOUSE uc008lyw.1 uc008lyw.2 uc008lyw.3 Essential to the formation of horizontal top connectors between outer hair cell stereocilia. Cell surface. Cell projection, kinocilium. Cell projection, stereocilium. Strongly expressed in the inner ear, detected in the testis, and barely detected in the eye. Detected in the six sensory areas of the inner ear by immunofluorescence. Expressed only in the sensory hair cells and associated with the stereocilia, the stiff microvilli forming the structure for mechanoreception of sound stimulation. Belongs to the stereocilin family. molecular_function cilium cell-matrix adhesion sensory perception of sound cell surface stereocilium stereocilium tip cell projection detection of mechanical stimulus involved in sensory perception of sound auditory receptor cell stereocilium organization kinocilium uc008lyw.1 uc008lyw.2 uc008lyw.3 
ENSMUST00000038398.7 Parp12 ENSMUST00000038398.7 poly (ADP-ribose) polymerase family, member 12 (from RefSeq NM_172893.3) ENSMUST00000038398.1 ENSMUST00000038398.2 ENSMUST00000038398.3 ENSMUST00000038398.4 ENSMUST00000038398.5 ENSMUST00000038398.6 NM_172893 PAR12_MOUSE Parp12 Q0VB94 Q80VL6 Q8BZ20 Q8K333 Q8R3U2 Zc3hdc1 uc009blg.1 uc009blg.2 uc009blg.3 uc009blg.4 Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins. Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA- COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=; Reaction=L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP- D-ribosyl)-L-cysteinyl-[protein]; Xref=Rhea:RHEA:56612, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:14624, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29950, ChEBI:CHEBI:57540, ChEBI:CHEBI:140607; Evidence=; Nucleus Auto-mono-ADP-ribosylated. Belongs to the ARTD/PARP family. NAD+ ADP-ribosyltransferase activity cellular_component nucleus transferase activity metal ion binding protein auto-ADP-ribosylation protein ADP-ribosylase activity uc009blg.1 uc009blg.2 uc009blg.3 uc009blg.4 
ENSMUST00000038403.12 Ica1 ENSMUST00000038403.12 islet cell autoantigen 1, transcript variant 1 (from RefSeq NM_010492.4) E9QLS3 ENSMUST00000038403.1 ENSMUST00000038403.10 ENSMUST00000038403.11 ENSMUST00000038403.2 ENSMUST00000038403.3 ENSMUST00000038403.4 ENSMUST00000038403.5 ENSMUST00000038403.6 ENSMUST00000038403.7 ENSMUST00000038403.8 ENSMUST00000038403.9 ICA69_MOUSE Ica1 Icap69 NM_010492 P97362 P97411 P97954 Q99M40 Q9R2C4 uc009axy.1 uc009axy.2 May play a role in neurotransmitter secretion. P97411; Q62083: Pick1; NbExp=2; IntAct=EBI-16056188, EBI-77550; Cytoplasm, cytosol Golgi apparatus membrane ; Peripheral membrane protein Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules. Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1 ; Synonyms=Alpha ; IsoId=P97411-1; Sequence=Displayed; Name=2 ; Synonyms=Beta ; IsoId=P97411-2; Sequence=VSP_050425, VSP_050426; Predominantly expressed in brain, pancreas and stomach mucosa. High expression also found in stomach muscle and testis. 129/SvJ mice lacking Ica1 do not display an obvious phenotype and age normally, while NOD mice without Ica1 develop diabetes and display sudden mid-life lethality but are resistant to cyclophosphamide-induced disease acceleration. Golgi membrane molecular_function protein binding cytoplasm Golgi apparatus Golgi stack cytosol neurotransmitter transport membrane protein domain specific binding cell junction dendrite transport vesicle membrane secretory granule membrane synaptic vesicle membrane cytoplasmic vesicle intracellular membrane-bounded organelle regulation of protein homodimerization activity synapse regulation of neurotransmitter secretion perinuclear region of cytoplasm regulation of insulin secretion uc009axy.1 uc009axy.2 
ENSMUST00000038404.6 Ccno ENSMUST00000038404.6 cyclin O (from RefSeq NM_001081062.2) CCNO_MOUSE Ccno ENSMUST00000038404.1 ENSMUST00000038404.2 ENSMUST00000038404.3 ENSMUST00000038404.4 ENSMUST00000038404.5 NM_001081062 P0C242 uc007rwz.1 uc007rwz.2 uc007rwz.3 Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking (By similarity). May be involved in apoptosis in lymphoid cells; however, this result requires additional evidences in vivo. May be involved in oocyte meiotic resumption in oocytes. Cytoplasm cleus, nucleolus Note=Localizes to the apical part of cytoplasm. Present in respiratory cells (at protein level). Expressed in multiciliated tissue in brain and fallopian tube (at protein level) (PubMed:26777464). Highly expressed in oocytes. Expressed in ependymal cells of the embryonic brain, but almost absent in the adult brain. Belongs to the cyclin family. Sequence=AK086507; Type=Frameshift; Evidence=; regulation of cyclin-dependent protein serine/threonine kinase activity mitotic cell cycle cyclin-dependent protein kinase holoenzyme complex nucleus cytoplasm centrosome protein phosphorylation cell cycle cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding cell projection organization response to drug mitotic cell cycle phase transition cell division cilium assembly multi-ciliated epithelial cell differentiation protein kinase activity uc007rwz.1 uc007rwz.2 uc007rwz.3 
ENSMUST00000038406.7 Akr1b8 ENSMUST00000038406.7 aldo-keto reductase family 1, member B8 (from RefSeq NM_008012.2) ALD2_MOUSE ENSMUST00000038406.1 ENSMUST00000038406.2 ENSMUST00000038406.3 ENSMUST00000038406.4 ENSMUST00000038406.5 ENSMUST00000038406.6 Fgfrp NM_008012 P45377 Q99JN4 uc009bgz.1 uc009bgz.2 uc009bgz.3 Reaction=an alditol + NAD(+) = an aldose + H(+) + NADH; Xref=Rhea:RHEA:12785, Rhea:RHEA-COMP:9554, Rhea:RHEA-COMP:9555, ChEBI:CHEBI:15378, ChEBI:CHEBI:15693, ChEBI:CHEBI:17522, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.21; Reaction=an alditol + NADP(+) = an aldose + H(+) + NADPH; Xref=Rhea:RHEA:12789, Rhea:RHEA-COMP:9554, Rhea:RHEA-COMP:9555, ChEBI:CHEBI:15378, ChEBI:CHEBI:15693, ChEBI:CHEBI:17522, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.21; Monomer. Cytoplasm By FGF-1. Belongs to the aldo/keto reductase family. retinoid metabolic process retinal dehydrogenase activity alditol:NADP+ 1-oxidoreductase activity cytoplasm mitochondrion cytosol alcohol dehydrogenase (NADP+) activity farnesol catabolic process oxidoreductase activity retinol metabolic process daunorubicin metabolic process doxorubicin metabolic process geranylgeranyl reductase activity indanol dehydrogenase activity NADP-retinol dehydrogenase activity oxidation-reduction process uc009bgz.1 uc009bgz.2 uc009bgz.3 
ENSMUST00000038407.6 Larp6 ENSMUST00000038407.6 La ribonucleoprotein 6, translational regulator (from RefSeq NM_026235.4) ENSMUST00000038407.1 ENSMUST00000038407.2 ENSMUST00000038407.3 ENSMUST00000038407.4 ENSMUST00000038407.5 LARP6_MOUSE NM_026235 Q8BN59 Q8C9A3 Q8CA51 Q9CTN3 Q9D3J0 uc009pzh.1 uc009pzh.2 uc009pzh.3 Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9 (By similarity). Interacts (via the HTH domain) with VIM/vimentin. Interacts (via C-terminus) with non-muscle myosin MYH10. Interacts (via C- terminus) with DHX9 (By similarity). Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Expressed in numerous tissues. Highest expression in heart and brain, intermediate in kidney, skeletal muscle and testis, lowest expression in testis (at protein level). The RRM domain mediates the association with collagen mRNAs stem-loops. nucleic acid binding RNA binding protein binding nucleus cytoplasm polysome RNA processing regulation of translation myosin binding positive regulation of collagen biosynthetic process RNA stem-loop binding positive regulation of translation mRNA 5'-UTR binding positive regulation of mRNA binding sequence-specific mRNA binding ribonucleoprotein complex uc009pzh.1 uc009pzh.2 uc009pzh.3 
ENSMUST00000038411.5 Adat3 ENSMUST00000038411.5 adenosine deaminase, tRNA-specific 3 (from RefSeq NM_001100606.1) ADAT3_MOUSE ENSMUST00000038411.1 ENSMUST00000038411.2 ENSMUST00000038411.3 ENSMUST00000038411.4 NM_001100606 Q6PAT0 uc007gdx.1 uc007gdx.2 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily. Val-225 is present instead of the conserved Glu which is an active site in the cytidine and deoxycytidylate deaminase family of enzymes. It is suggested that this protein may act as a regulatory subunit. tRNA wobble adenosine to inosine editing catalytic activity tRNA processing metal ion binding tRNA-specific adenosine-34 deaminase activity tRNA-specific adenosine-34 deaminase complex uc007gdx.1 uc007gdx.2 
ENSMUST00000038421.8 Lsm1 ENSMUST00000038421.8 LSM1 homolog, mRNA degradation associated (from RefSeq NM_026032.1) ENSMUST00000038421.1 ENSMUST00000038421.2 ENSMUST00000038421.3 ENSMUST00000038421.4 ENSMUST00000038421.5 ENSMUST00000038421.6 ENSMUST00000038421.7 LSM1_MOUSE NM_026032 Q8VC85 uc009lha.1 uc009lha.2 uc009lha.3 Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase (By similarity). LSm subunits form a heteromer with a donut shape (By similarity). Q8VC85; Q7TMF2: Eri1; NbExp=3; IntAct=EBI-16026183, EBI-16026214; Cytoplasm Cytoplasm, P-body Belongs to the snRNP Sm proteins family. deadenylation-dependent decapping of nuclear-transcribed mRNA RNA cap binding P-body nuclear-transcribed mRNA catabolic process RNA binding mRNA binding protein binding nucleus cytoplasm mRNA processing RNA splicing RNA metabolic process stem cell population maintenance axon dendrite pre-mRNA binding neuronal cell body negative regulation of neuron differentiation histone mRNA catabolic process messenger ribonucleoprotein complex Lsm1-7-Pat1 complex uc009lha.1 uc009lha.2 uc009lha.3 
ENSMUST00000038422.8 Irf2bpl ENSMUST00000038422.8 interferon regulatory factor 2 binding protein-like (from RefSeq NM_145836.2) ENSMUST00000038422.1 ENSMUST00000038422.2 ENSMUST00000038422.3 ENSMUST00000038422.4 ENSMUST00000038422.5 ENSMUST00000038422.6 ENSMUST00000038422.7 Eap1 I2BPL_MOUSE Kiaa1865 NM_145836 Q3TBU9 Q3U483 Q3USE5 Q69Z84 Q8BUS1 Q8C011 Q8K3X4 uc007oia.1 uc007oia.2 uc007oia.3 uc007oia.4 Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with CTNNB1. Nucleus Belongs to the IRF2BP family. Sequence=BAD32560.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleus nucleoplasm nervous system development protein ubiquitination transferase activity positive regulation of transcription from RNA polymerase II promoter development of secondary female sexual characteristics metal ion binding ubiquitin protein ligase activity uc007oia.1 uc007oia.2 uc007oia.3 uc007oia.4 
ENSMUST00000038424.14 Txndc11 ENSMUST00000038424.14 thioredoxin domain containing 11, transcript variant 1 (from RefSeq NM_029582.2) ENSMUST00000038424.1 ENSMUST00000038424.10 ENSMUST00000038424.11 ENSMUST00000038424.12 ENSMUST00000038424.13 ENSMUST00000038424.2 ENSMUST00000038424.3 ENSMUST00000038424.4 ENSMUST00000038424.5 ENSMUST00000038424.6 ENSMUST00000038424.7 ENSMUST00000038424.8 ENSMUST00000038424.9 NM_029582 Q8BMR8 Q8K2W3 Q8VCK9 TXD11_MOUSE uc007yet.1 uc007yet.2 uc007yet.3 May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation (By similarity). Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA (By similarity). Endoplasmic reticulum membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2W3-1; Sequence=Displayed; Name=2; IsoId=Q8K2W3-2; Sequence=VSP_014338, VSP_014339; Belongs to the protein disulfide isomerase family. Sequence=AAH19564.1; Type=Erroneous initiation; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane cell redox homeostasis uc007yet.1 uc007yet.2 uc007yet.3 
ENSMUST00000038431.8 Pdk2 ENSMUST00000038431.8 pyruvate dehydrogenase kinase, isoenzyme 2, transcript variant 1 (from RefSeq NM_133667.2) ENSMUST00000038431.1 ENSMUST00000038431.2 ENSMUST00000038431.3 ENSMUST00000038431.4 ENSMUST00000038431.5 ENSMUST00000038431.6 ENSMUST00000038431.7 NM_133667 PDK2_MOUSE Q8VC63 Q9JK42 uc007kzu.1 uc007kzu.2 uc007kzu.3 uc007kzu.4 Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:22360721). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. Reaction=ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]; Xref=Rhea:RHEA:23052, Rhea:RHEA-COMP:13689, Rhea:RHEA-COMP:13690, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23053; Evidence=; Homodimer, and heterodimer with PDK1. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). Q9JK42; O08908: Pik3r2; NbExp=3; IntAct=EBI-643530, EBI-643570; Mitochondrion matrix Detected in heart (at protein level). Up-regulated by glucose and palmitic acid. Up-regulated by PPARD. No visible phenotype, due to the fact that PDK2- deficient mice have increased PDK1 levels (PubMed:21411764). Mice have lower blood glucose levels in the fed state, but not after fasting. Likewise, they display increased pyruvate dehydrogenase activity in liver and skeletal muscle in the fed state, but not after fasting. Fasting mice lacking both PDK2 and PDK4 show strongly decreased blood glucose levels, increased circulating ketone body levels leading to ketoacidosis with dangerously low blood pH levels, hypothermia, and ultimately death (PubMed:22360721). Belongs to the PDK/BCKDK protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity pyruvate dehydrogenase (acetyl-transferring) kinase activity protein binding ATP binding nucleoplasm mitochondrion mitochondrial matrix cytosol mitochondrial pyruvate dehydrogenase complex carbohydrate metabolic process glucose metabolic process regulation of gluconeogenesis protein phosphorylation regulation of pH insulin receptor signaling pathway regulation of acetyl-CoA biosynthetic process from pyruvate regulation of cellular ketone metabolic process regulation of glucose metabolic process kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation cellular response to nutrient cellular response to reactive oxygen species glucose homeostasis protein homodimerization activity macromolecular complex binding pyruvate dehydrogenase complex protein heterodimerization activity regulation of calcium-mediated signaling intrinsic apoptotic signaling pathway by p53 class mediator uc007kzu.1 uc007kzu.2 uc007kzu.3 uc007kzu.4 
ENSMUST00000038434.4 Rpp25l ENSMUST00000038434.4 ribonuclease P/MRP 25 subunit-like (from RefSeq NM_027278.3) ENSMUST00000038434.1 ENSMUST00000038434.2 ENSMUST00000038434.3 NM_027278 Q99JH1 Q9CYX4 RP25L_MOUSE uc008sjh.1 uc008sjh.2 uc008sjh.3 uc008sjh.4 May be a component of ribonuclease P or MRP. Nucleus Belongs to the histone-like Alba family. nucleic acid binding cellular_component nucleus biological_process uc008sjh.1 uc008sjh.2 uc008sjh.3 uc008sjh.4 
ENSMUST00000038439.4 Dnajc17 ENSMUST00000038439.4 DnaJ heat shock protein family (Hsp40) member C17 (from RefSeq NM_139139.2) A3KGH2 DJC17_MOUSE ENSMUST00000038439.1 ENSMUST00000038439.2 ENSMUST00000038439.3 NM_139139 Q8C5R1 Q91WT4 uc008ltg.1 uc008ltg.2 uc008ltg.3 May negatively affect PAX8-induced thyroglobulin/TG transcription. Cytoplasm Nucleus Note=Predominantly nuclear. Expressed in the thyroid gland. Embryonic lethal after the morula stage. negative regulation of transcription from RNA polymerase II promoter nucleic acid binding RNA binding nucleus cytoplasm toxin transport uc008ltg.1 uc008ltg.2 uc008ltg.3 
ENSMUST00000038445.13 Mybph ENSMUST00000038445.13 myosin binding protein H, transcript variant 1 (from RefSeq NM_016749.2) E9QKH7 ENSMUST00000038445.1 ENSMUST00000038445.10 ENSMUST00000038445.11 ENSMUST00000038445.12 ENSMUST00000038445.2 ENSMUST00000038445.3 ENSMUST00000038445.4 ENSMUST00000038445.5 ENSMUST00000038445.6 ENSMUST00000038445.7 ENSMUST00000038445.8 ENSMUST00000038445.9 MYBPH_MOUSE NM_016749 P70402 uc007cri.1 uc007cri.2 uc007cri.3 Binds to myosin; probably involved in interaction with thick myofilaments in the A-band. Skeletal muscle. Expressed at low levels in heart ventricles. Belongs to the immunoglobulin superfamily. MyBP family. cell adhesion myosin filament uc007cri.1 uc007cri.2 uc007cri.3 
ENSMUST00000038446.10 Myl12b ENSMUST00000038446.10 myosin, light chain 12B, regulatory (from RefSeq NM_023402.2) ENSMUST00000038446.1 ENSMUST00000038446.2 ENSMUST00000038446.3 ENSMUST00000038446.4 ENSMUST00000038446.5 ENSMUST00000038446.6 ENSMUST00000038446.7 ENSMUST00000038446.8 ENSMUST00000038446.9 ML12B_MOUSE Mrlc2 Mylc2b NM_023402 Q3THE2 Q3TVH2 Q9CQL8 uc008dlv.1 uc008dlv.2 uc008dlv.3 Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin heavy chain MYO19. Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment. This chain binds calcium. Sequence=BAE35646.1; Type=Frameshift; Evidence=; stress fiber calcium ion binding brush border regulation of cell shape myosin complex myosin II complex Z disc myosin heavy chain binding macromolecular complex apical part of cell metal ion binding cell cortex region uc008dlv.1 uc008dlv.2 uc008dlv.3 
ENSMUST00000038447.6 Efhc1 ENSMUST00000038447.6 EF-hand domain (C-terminal) containing 1 (from RefSeq NM_027974.1) B2CKC6 B2CKC6_MOUSE ENSMUST00000038447.1 ENSMUST00000038447.2 ENSMUST00000038447.3 ENSMUST00000038447.4 ENSMUST00000038447.5 Efhc1 NM_027974 uc007alf.1 uc007alf.2 uc007alf.3 uc007alf.4 Cytoplasm, cytoskeleton, cilium axoneme mitotic cytokinesis spindle pole calcium ion binding centrosome mitotic spindle organization cerebral cortex cell migration alpha-tubulin binding regulation of cell division mitotic spindle uc007alf.1 uc007alf.2 uc007alf.3 uc007alf.4 
ENSMUST00000038448.7 Tmprss11b ENSMUST00000038448.7 transmembrane protease, serine 11B (from RefSeq NM_177024.5) ENSMUST00000038448.1 ENSMUST00000038448.2 ENSMUST00000038448.3 ENSMUST00000038448.4 ENSMUST00000038448.5 ENSMUST00000038448.6 Hatl5 NM_177024 Q14C59 Q8BZ13 Q8BZ30 TM11B_MOUSE Tmprss11bnl uc008xxu.1 uc008xxu.2 uc008xxu.3 Serine protease. Inhibited by aprotinin, leupeptin, benzamidine, SERPINA1, SPINT1 and SPINT2. Cell membrane ; Single-pass type II membrane protein Expressed in esophagus, cervix, tongue, and testes. Belongs to the peptidase S1 family. serine-type endopeptidase activity extracellular region plasma membrane integral component of plasma membrane proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc008xxu.1 uc008xxu.2 uc008xxu.3 
ENSMUST00000038450.2 4632404H12Rik ENSMUST00000038450.2 RIKEN cDNA 4632404H12 gene (from RefSeq NR_130957.1) ENSMUST00000038450.1 NR_130957 uc008qab.1 uc008qab.2 uc008qab.3 uc008qab.4 uc008qab.1 uc008qab.2 uc008qab.3 uc008qab.4 
ENSMUST00000038474.14 Exosc2 ENSMUST00000038474.14 exosome component 2 (from RefSeq NM_144886.3) ENSMUST00000038474.1 ENSMUST00000038474.10 ENSMUST00000038474.11 ENSMUST00000038474.12 ENSMUST00000038474.13 ENSMUST00000038474.2 ENSMUST00000038474.3 ENSMUST00000038474.4 ENSMUST00000038474.5 ENSMUST00000038474.6 ENSMUST00000038474.7 ENSMUST00000038474.8 ENSMUST00000038474.9 EXOS2_MOUSE NM_144886 Q8VBV3 Rrp4 uc008jdy.1 uc008jdy.2 uc008jdy.3 uc008jdy.4 Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7 (By similarity). Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with DIS3. Interacts with GTPBP1. Interacts with ZFP36L1 (via N-terminus). Cytoplasm Nucleus, nucleolus Nucleus Belongs to the RRP4 family. nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA binding nucleus nucleolus cytoplasm rRNA processing positive regulation of cell growth nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U4 snRNA 3'-end processing exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay CUT catabolic process nuclear polyadenylation-dependent rRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription polyadenylation-dependent snoRNA 3'-end processing uc008jdy.1 uc008jdy.2 uc008jdy.3 uc008jdy.4 
ENSMUST00000038475.9 Fa2h ENSMUST00000038475.9 fatty acid 2-hydroxylase (from RefSeq NM_178086.3) ENSMUST00000038475.1 ENSMUST00000038475.2 ENSMUST00000038475.3 ENSMUST00000038475.4 ENSMUST00000038475.5 ENSMUST00000038475.6 ENSMUST00000038475.7 ENSMUST00000038475.8 FA2H_MOUSE Fa2h Faah NM_178086 Q2M2M0 Q5MPP0 Q5RL53 Q8BTH1 Q8R0M0 Q8R0V1 uc009nmf.1 uc009nmf.2 uc009nmf.3 uc009nmf.4 Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:15658937, PubMed:16998236, PubMed:22517924). FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (PubMed:22517924). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (PubMed:15658937, PubMed:18815260). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (By similarity). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (PubMed:21628453). Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (PubMed:22517924). Reaction=a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O; Xref=Rhea:RHEA:38855, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:76177, ChEBI:CHEBI:83955; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38856; Evidence=; Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 = (R)- 2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O; Xref=Rhea:RHEA:38551, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:75927; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38552; Evidence=; Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate = (R)- 2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O; Xref=Rhea:RHEA:39815, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:25629, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57562; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39816; Evidence=; Reaction=docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2- hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O; Xref=Rhea:RHEA:39819, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:23858, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:76722; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39820; Evidence=; Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate = (R)- 2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O; Xref=Rhea:RHEA:38559, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:31014, ChEBI:CHEBI:75935; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38560; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center. ; Sphingolipid metabolism; galactosylceramide biosynthesis. Lipid metabolism; fatty acid metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Microsome membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5MPP0-1; Sequence=Displayed; Name=2; IsoId=Q5MPP0-2; Sequence=VSP_029838; Name=3; IsoId=Q5MPP0-3; Sequence=VSP_029837; Expressed in brain (at protein level) (PubMed:16998236). Detected in cerebellum and forebrain (PubMed:18815260, PubMed:15658937). Expression in the white matter is mainly restricted in oligodendrocytes (PubMed:15658937). Expressed in stomach, kidney, skin and testis (PubMed:15658937). Expressed in sebaceous gland (PubMed:21628453). Levels increase rapidly in brains from newborns, in parallel with myelination in the central nervous system. Present at very low levels in newborns. Levels are highest at 2 to 3 weeks, and then decrease slightly to reach an constant, intermediate level after 4 months. Constitutively expressed at an intermediate level throughout adult life. The histidine box domains may contain the active site and/or be involved in metal ion binding. The N-terminal cytochrome b5 heme-binding domain is essential for catalytic activity. Knockout mice have normal oligodentrocyte differentiation and develope structural and functional normal myelin up to early adulthood. However, aged knockout mice show a massive axon and myelin sheath degeneration in the spinal cord (PubMed:18815260). Knockout mice show delayed fur development and a cyclic alopecia (PubMed:21628453). Belongs to the sterol desaturase family. SCS7 subfamily. Sequence=AAH46985.1; Type=Frameshift; Evidence=; Sequence=AAI11913.1; Type=Erroneous initiation; Evidence=; sebaceous gland cell differentiation iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process glucosylceramide biosynthetic process galactosylceramide biosynthetic process lipid biosynthetic process membrane integral component of membrane oxidoreductase activity heme binding lipid modification organelle membrane central nervous system myelin maintenance peripheral nervous system myelin maintenance regulation of cell proliferation regulation of hair cycle intracellular membrane-bounded organelle plasma membrane raft organization ceramide biosynthetic process metal ion binding oxidation-reduction process establishment of skin barrier fatty acid alpha-hydroxylase activity uc009nmf.1 uc009nmf.2 uc009nmf.3 uc009nmf.4 
ENSMUST00000038482.7 Lcn8 ENSMUST00000038482.7 lipocalin 8 (from RefSeq NM_033145.1) ENSMUST00000038482.1 ENSMUST00000038482.2 ENSMUST00000038482.3 ENSMUST00000038482.4 ENSMUST00000038482.5 ENSMUST00000038482.6 LCN8_MOUSE NM_033145 Q924P3 uc008ita.1 uc008ita.2 uc008ita.3 uc008ita.4 May play a role in male fertility. May act as a retinoid carrier protein within the epididymis. Secreted Predominantly expressed in epididymis. Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component extracellular region response to hormone small molecule binding uc008ita.1 uc008ita.2 uc008ita.3 uc008ita.4 
ENSMUST00000038488.17 Sidt2 ENSMUST00000038488.17 SID1 transmembrane family, member 2, transcript variant 2 (from RefSeq NM_172257.4) ENSMUST00000038488.1 ENSMUST00000038488.10 ENSMUST00000038488.11 ENSMUST00000038488.12 ENSMUST00000038488.13 ENSMUST00000038488.14 ENSMUST00000038488.15 ENSMUST00000038488.16 ENSMUST00000038488.2 ENSMUST00000038488.3 ENSMUST00000038488.4 ENSMUST00000038488.5 ENSMUST00000038488.6 ENSMUST00000038488.7 ENSMUST00000038488.8 ENSMUST00000038488.9 NM_172257 Q80XD7 Q8CIF6 Q922R2 SIDT2_MOUSE uc009pgt.1 uc009pgt.2 uc009pgt.3 uc009pgt.4 Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA and DNA is directly imported into lysosomes in an ATP- dependent manner, and degraded (PubMed:27046251, PubMed:27846365, PubMed:28724756). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA (PubMed:27846365). Binds long double- stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (PubMed:26067272). Interacts with adapter protein complex 1 (AP-1) and AP-2, but not AP-3 and AP-4 (PubMed:28724756). Interacts with LAMP2 (PubMed:27046251). Lysosome membrane ulti-pass membrane protein Cell membrane Note=Mainly localizes to lysosomes and only partly to the plasma membrane (By similarity). Lysosomal localization is required for SIDT2-mediated intracellular degradation of endogenous RNA (PubMed:28724756). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CIF6-1; Sequence=Displayed; Name=2; IsoId=Q8CIF6-2; Sequence=VSP_013525; Widely expressed, including in the liver, brain and kidney (at protein level). Glycosylated. Knockout mice demonstrate a statistically significant departure from Mendel's law, but there is no significant differences in their weights or appearance as compared to wild-type controls as newborns. At 5 weeks of age, male mice show reduced weight and size as compared to control animals. This phenotype is not observed in females. Mutant animals exhibit increased fasting glucose levels and impaired glucose tolerance, probably due to impaired insulin granule exocytosis by pancreatic islet cells (PubMed:23776622). At 3 months of age, serum triglyceride and free fatty acid levels increase in knockout mice fed on normal chow. Mice gradually develop hepatic steatosis, with varying degrees of inflammatory changes (PubMed:27233614). Belongs to the SID1 family. cell morphogenesis type B pancreatic cell development DNA binding RNA binding double-stranded RNA binding protein binding lysosome lysosomal membrane plasma membrane RNA catabolic process response to glucose membrane integral component of membrane dsRNA transport AP-2 adaptor complex binding AP-1 adaptor complex binding glucose homeostasis type B pancreatic cell proliferation RNA transport nucleic acid transmembrane transporter activity RNA transmembrane transporter activity regulation of insulin secretion involved in cellular response to glucose stimulus uc009pgt.1 uc009pgt.2 uc009pgt.3 uc009pgt.4 
ENSMUST00000038489.6 Pygo1 ENSMUST00000038489.6 pygopus 1 (from RefSeq NM_028116.3) ENSMUST00000038489.1 ENSMUST00000038489.2 ENSMUST00000038489.3 ENSMUST00000038489.4 ENSMUST00000038489.5 NM_028116 PYGO1_MOUSE Q9D0P5 uc009qqi.1 uc009qqi.2 uc009qqi.3 Involved in signal transduction through the Wnt pathway. Interacts with BCL9 via The PHD-type zinc finger motiv, and thereby becomes part of the nuclear beta-catenin/TCF complex. Found in a complex with BCL9L, CDC73, CTNNB1 and PYGO1. Interacts with histone H3 mono-, di- or tri-methylated at 'Lys4' (H3K4me1, H3K4me2, H3K4me3); the interaction is enhanced by the interaction with BCL9 (By similarity). Q9D0P5; Q9W0N9: ebd1; Xeno; NbExp=3; IntAct=EBI-8607760, EBI-141287; Nucleus kidney development hematopoietic progenitor cell differentiation protein binding nucleus spermatid development spermatid nucleus differentiation post-embryonic development Wnt signaling pathway protein localization to nucleus methylated histone binding positive regulation of transcription from RNA polymerase II promoter metal ion binding canonical Wnt signaling pathway uc009qqi.1 uc009qqi.2 uc009qqi.3 
ENSMUST00000038495.5 Crp ENSMUST00000038495.5 C-reactive protein, pentraxin-related (from RefSeq NM_007768.4) CRP_MOUSE E9PZ20 ENSMUST00000038495.1 ENSMUST00000038495.2 ENSMUST00000038495.3 ENSMUST00000038495.4 NM_007768 P14847 Ptx1 uc011wwq.1 uc011wwq.2 uc011wwq.3 Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 calcium ions per subunit. ; Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 (By similarity). Secreted. Found in plasma. The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. Belongs to the pentraxin family. Name=Protein Spotlight; Note=No more Christmas pudding? - Issue 30 of January 2003; URL="https://web.expasy.org/spotlight/back_issues/030"; complement component C1q binding calcium ion binding extracellular region extracellular space acute-phase response complement activation, classical pathway positive regulation of gene expression negative regulation of macrophage derived foam cell differentiation negative regulation of lipid storage regulation of low-density lipoprotein particle clearance cholesterol binding low-density lipoprotein particle binding filopodium growth cone negative regulation of superoxide anion generation positive regulation of superoxide anion generation wound healing identical protein binding protein homodimerization activity innate immune response positive regulation of nitric oxide biosynthetic process metal ion binding low-density lipoprotein particle receptor binding protein polymerization cellular response to calcium ion positive regulation of dendrite development regulation of interleukin-8 secretion uc011wwq.1 uc011wwq.2 uc011wwq.3 
ENSMUST00000038498.10 Bag4 ENSMUST00000038498.10 BCL2-associated athanogene 4 (from RefSeq NM_026121.3) BAG4_MOUSE ENSMUST00000038498.1 ENSMUST00000038498.2 ENSMUST00000038498.3 ENSMUST00000038498.4 ENSMUST00000038498.5 ENSMUST00000038498.6 ENSMUST00000038498.7 ENSMUST00000038498.8 ENSMUST00000038498.9 NM_026121 Q3TRL9 Q8CI61 Q91VT5 Q9CWG2 Sodd uc009lgy.1 uc009lgy.2 uc009lgy.3 uc009lgy.4 Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling (By similarity). Negative regulator of PRKN translocation to damaged mitochondria (By similarity). Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to the death domain of TNFRSF12 (By similarity). Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Interacts with PRKN (By similarity). Cytoplasm. Sequence=AAH37239.1; Type=Erroneous initiation; Evidence=; protein binding nucleus cytoplasm cytosol plasma membrane apoptotic process positive regulation of fibroblast migration positive regulation of actin filament polymerization ubiquitin protein ligase binding positive regulation of peptidyl-serine phosphorylation regulation of apoptotic process positive regulation of cell adhesion chaperone binding protein heterooligomerization positive regulation of stress fiber assembly positive regulation of protein kinase B signaling cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus protein localization to plasma membrane negative regulation of mRNA modification ruffle assembly negative regulation of protein targeting to mitochondrion negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity uc009lgy.1 uc009lgy.2 uc009lgy.3 uc009lgy.4 
ENSMUST00000038507.7 Ly6g6f ENSMUST00000038507.7 lymphocyte antigen 6 family member G6F (from RefSeq NM_001163192.1) B2RXM6 B2RXM6_MOUSE E9Q7V4 ENSMUST00000038507.1 ENSMUST00000038507.2 ENSMUST00000038507.3 ENSMUST00000038507.4 ENSMUST00000038507.5 ENSMUST00000038507.6 Ly6g6f NM_001163192 uc012aqz.1 uc012aqz.2 uc012aqz.3 uc012aqz.4 molecular_function cellular_component biological_process membrane integral component of membrane uc012aqz.1 uc012aqz.2 uc012aqz.3 uc012aqz.4 
ENSMUST00000038514.15 Nup54 ENSMUST00000038514.15 nucleoporin 54, transcript variant 2 (from RefSeq NM_183392.2) ENSMUST00000038514.1 ENSMUST00000038514.10 ENSMUST00000038514.11 ENSMUST00000038514.12 ENSMUST00000038514.13 ENSMUST00000038514.14 ENSMUST00000038514.2 ENSMUST00000038514.3 ENSMUST00000038514.4 ENSMUST00000038514.5 ENSMUST00000038514.6 ENSMUST00000038514.7 ENSMUST00000038514.8 ENSMUST00000038514.9 NM_183392 NUP54_MOUSE Q3TSI2 Q8BTS4 Q8BU42 uc008ydk.1 uc008ydk.2 uc008ydk.3 Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUP58. Interacts with NUTF2. Nucleus, nuclear pore complex Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter. Contains FG repeats. O-glycosylated. Belongs to the NUP54 family. nucleus nuclear envelope nuclear pore protein targeting NLS-bearing protein import into nucleus nucleocytoplasmic transport nuclear pore organization protein transport membrane structural constituent of nuclear pore nuclear membrane macromolecular complex protein targeting to nuclear inner membrane regulation of protein import into nucleus nuclear pore central transport channel mRNA transport protein homooligomerization protein heterotetramerization protein heterooligomerization protein heterotrimerization uc008ydk.1 uc008ydk.2 uc008ydk.3 
ENSMUST00000038523.15 Ric8b ENSMUST00000038523.15 RIC8 guanine nucleotide exchange factor B, transcript variant 2 (from RefSeq NM_183172.2) ENSMUST00000038523.1 ENSMUST00000038523.10 ENSMUST00000038523.11 ENSMUST00000038523.12 ENSMUST00000038523.13 ENSMUST00000038523.14 ENSMUST00000038523.2 ENSMUST00000038523.3 ENSMUST00000038523.4 ENSMUST00000038523.5 ENSMUST00000038523.6 ENSMUST00000038523.7 ENSMUST00000038523.8 ENSMUST00000038523.9 NM_183172 Q58L65 Q80XE1 RIC8B_MOUSE uc007gkx.1 uc007gkx.2 uc007gkx.3 uc007gkx.4 Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP (By similarity). Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction. Interacts with GDP-bound G alpha proteins GNAI1, GNAL, GNAS and GNAQ. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Cytoplasm, cell cortex Note=Localizes to the cell cortex. Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q80XE1-2; Sequence=Displayed; Name=1; IsoId=Q80XE1-1; Sequence=VSP_039867; Predominantly expressed in the mature olfactory sensory neurons and also in a few regions in the brain. Belongs to the synembryn family. G-protein alpha-subunit binding guanyl-nucleotide exchange factor activity GTPase activator activity cytoplasm centrosome cytosol plasma membrane cell cortex G-protein coupled receptor signaling pathway positive regulation of GTPase activity uc007gkx.1 uc007gkx.2 uc007gkx.3 uc007gkx.4 
ENSMUST00000038529.2 Rbbp8nl ENSMUST00000038529.2 RBBP8 N-terminal like (from RefSeq NM_173031.3) A2ABX0 A2ABX0_MOUSE BC066135 ENSMUST00000038529.1 NM_173031 Rbbp8nl uc008oiw.1 uc008oiw.2 molecular_function biological_process uc008oiw.1 uc008oiw.2 
ENSMUST00000038532.2 Mc3r ENSMUST00000038532.2 melanocortin 3 receptor (from RefSeq NM_008561.3) ENSMUST00000038532.1 Mc3r NM_008561 Q544G7 Q544G7_MOUSE uc008ocl.1 uc008ocl.2 This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis and adaptation to food restriction. Disruption of this gene results in an increased ratio of weight gain to food intake, increased fat mass, and decreased lean mass, without having a large effect on insulin sensitivity or glucose metabolism. [provided by RefSeq, Dec 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK038677.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. regulation of heart rate G-protein coupled receptor activity melanocortin receptor activity melanocyte-stimulating hormone receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway regulation of blood pressure membrane integral component of membrane peptide hormone binding homoiothermy neuropeptide binding sodium ion homeostasis uc008ocl.1 uc008ocl.2 
ENSMUST00000038537.9 Wtip ENSMUST00000038537.9 WT1 interacting protein (from RefSeq NM_207212.3) ENSMUST00000038537.1 ENSMUST00000038537.2 ENSMUST00000038537.3 ENSMUST00000038537.4 ENSMUST00000038537.5 ENSMUST00000038537.6 ENSMUST00000038537.7 ENSMUST00000038537.8 NM_207212 Q7TQJ8 Q8CG89 WTIP_MOUSE uc009gis.1 uc009gis.2 uc009gis.3 uc009gis.4 uc009gis.5 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture. In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1- dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Forms homodimers. Interacts with EIF4E, AGO1, AGO2, DCP2, DDX6, LATS1, LATS2, SAV1, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM domains) with VHL (By similarity). Interacts with CD2AP and WT1. Interacts (via LIM domains) with SNAI1 (via SNAG domain), SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain). Interacts with ROR2. Following treatment with bacterial lipopolysaccharide (LPS), forms a complex with MAPK8IP3 and dynein intermediate chain. Interacts with PRICKLE3 (By similarity). Cell junction, focal adhesion. Cell junction, adherens junction. Nucleus. Cytoplasm, cytosol. Cell membrane. Note=In adherent but isolated podocytes, targets to focal adhesions and then shifts to adherens junctions after cells make homotypic contacts. Following podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide, translocates from sites of cell-cell contacts into the cytosol and nucleus. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear translocation requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell contacts several hours after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane. Expressed in kidney, lung, eye and ovary. In kidney, restricted to podocytes. From 9.5 to 11.5 dpc, expressed in the branchial arches, otic vesicle, limb buds, somites, craniofacial mesenchyme and tail buds. At 14.5 dpc, expressed in the developing tongue, nasal cavity, palate, adrenal gland, in the forebrain, dorsal root ganglia and in the somites. At 14.5 dpc, also detected in lung, rib cartilage, kidney and intestine (at protein level). In the kidney, expression peaks at 15 to 16 dpc and decreases thereafter, but persists in adulthood. Belongs to the zyxin/ajuba family. P-body response to hypoxia transcription corepressor activity protein binding nucleus transcription factor complex cytoplasm cytosol plasma membrane cell-cell junction adherens junction focal adhesion cytoskeleton organization membrane regulation of cell morphogenesis cell projection organization cell junction gene silencing by RNA gene silencing by miRNA negative regulation of hippo signaling metal ion binding negative regulation of nucleic acid-templated transcription positive regulation of gene silencing by miRNA uc009gis.1 uc009gis.2 uc009gis.3 uc009gis.4 uc009gis.5 
ENSMUST00000038539.8 1700123O20Rik ENSMUST00000038539.8 RIKEN cDNA 1700123O20 gene (from RefSeq NM_021437.2) CN119_MOUSE ENSMUST00000038539.1 ENSMUST00000038539.2 ENSMUST00000038539.3 ENSMUST00000038539.4 ENSMUST00000038539.5 ENSMUST00000038539.6 ENSMUST00000038539.7 MNCb-2990 NM_021437 Q921Q2 Q9JJ93 uc007twy.1 uc007twy.2 uc007twy.3 uc007twy.4 Mitochondrion molecular_function mitochondrion cytosol biological_process uc007twy.1 uc007twy.2 uc007twy.3 uc007twy.4 
ENSMUST00000038551.8 Ppp1r21 ENSMUST00000038551.8 protein phosphatase 1, regulatory subunit 21 (from RefSeq NM_028658.4) B2RPZ6 Ccdc128 ENSMUST00000038551.1 ENSMUST00000038551.2 ENSMUST00000038551.3 ENSMUST00000038551.4 ENSMUST00000038551.5 ENSMUST00000038551.6 ENSMUST00000038551.7 Klraq1 NM_028658 PPR21_MOUSE Q3KQN7 Q3TDD9 Q3U2U9 Q8BHS9 Q9D1A1 uc008dvo.1 uc008dvo.2 uc008dvo.3 uc008dvo.4 Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway. Interacts with PPP1CA. Early endosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TDD9-1; Sequence=Displayed; Name=2; IsoId=Q3TDD9-2; Sequence=VSP_024988, VSP_024990; Expressed at 16 dpc in the cortex (at protein level). [Isoform 2]: May be due to intron retention. Sequence=AAI06119.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; early endosome biological_process uc008dvo.1 uc008dvo.2 uc008dvo.3 uc008dvo.4 
ENSMUST00000038552.13 Coro7 ENSMUST00000038552.13 coronin 7 (from RefSeq NM_030205.4) CORO7_MOUSE ENSMUST00000038552.1 ENSMUST00000038552.10 ENSMUST00000038552.11 ENSMUST00000038552.12 ENSMUST00000038552.2 ENSMUST00000038552.3 ENSMUST00000038552.4 ENSMUST00000038552.5 ENSMUST00000038552.6 ENSMUST00000038552.7 ENSMUST00000038552.8 ENSMUST00000038552.9 NM_030205 Q3UDJ4 Q6P8Y8 Q8C9V7 Q9D2V7 uc007xzy.1 uc007xzy.2 uc007xzy.3 F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity). Interacts with clathrin adapter AP1 complex. This interaction takes place at Golgi membranes and not AP1-positive endosomal membranes. Interacts (when ubiquitinated at Lys-469) with EPS15 (By similarity). Golgi apparatus membrane Golgi apparatus, trans-Golgi network Cytoplasmic vesicle Cytoplasm, cytosol Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments. In the adult, widely expressed with highest levels in brain, thymus and kidney and low levels in skeletal and heart muscle. Not expressed in lung. In the eye, strongly expressed in the outer plexiform layer of the retina. In the intestine, expressed both in terminally differentiated epithelial cells and in crypt epithelium. In the embryo, strongest expression is seen in brain, thymus, intestine, apical epidermal layers of the skin and developing lens fibers of the eye. In the embryo, expressed from 5 dpc and levels increase strongly until 15 dpc. The membrane-associated form is phosphorylated on tyrosine residues. Ubiquitinated via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex: 'Lys-33'-linked ubiquitination promotes interaction with EPS15 and facilitates actin polymerization at the trans-Golgi network, thereby facilitating post-Golgi trafficking. Deubiquitinated by ZRANB1/TRABID (By similarity). Belongs to the WD repeat coronin family. Golgi membrane actin binding cytoplasm Golgi apparatus trans-Golgi network cytosol Golgi to endosome transport actin filament organization Golgi organization protein transport membrane integral component of membrane cell migration establishment of cell polarity actin filament polymerization cytoplasmic vesicle actin filament binding uc007xzy.1 uc007xzy.2 uc007xzy.3 
ENSMUST00000038558.9 Klf16 ENSMUST00000038558.9 Kruppel-like transcription factor 16 (from RefSeq NM_078477.2) Bteb4 Drrf ENSMUST00000038558.1 ENSMUST00000038558.2 ENSMUST00000038558.3 ENSMUST00000038558.4 ENSMUST00000038558.5 ENSMUST00000038558.6 ENSMUST00000038558.7 ENSMUST00000038558.8 KLF16_MOUSE NM_078477 P58334 Q3U3Y4 Q8C8S2 uc007gdt.1 uc007gdt.2 uc007gdt.3 Transcription factor that binds GC and GT boxes in the D1A, D2 and D3 dopamine receptor promoters and displaces Sp1 and Sp3 from these sequences. It modulates dopaminergic transmission in the brain by repressing or activating transcription from several different promoters depending on cellular context. Nucleus. High expression in brain; olfactory tubercle, olfactory bulb, nucleus accumbens, striatum, hippocampal CA1 region, amygdala, dentate gyrus and frontal cortex. Moderate expression in hippocampal CA2-3 regions, piriform cortex, septum, and distinct thalamic nuclei. Low expression in the cerebellum. The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions. Belongs to the Sp1 C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription from RNA polymerase II promoter dopamine receptor signaling pathway metal ion binding uc007gdt.1 uc007gdt.2 uc007gdt.3 
ENSMUST00000038562.9 Spsb1 ENSMUST00000038562.9 splA/ryanodine receptor domain and SOCS box containing 1, transcript variant 1 (from RefSeq NM_029035.3) ENSMUST00000038562.1 ENSMUST00000038562.2 ENSMUST00000038562.3 ENSMUST00000038562.4 ENSMUST00000038562.5 ENSMUST00000038562.6 ENSMUST00000038562.7 ENSMUST00000038562.8 NM_029035 Q5FWI0 Q8BJA4 Q9D5L7 SPSB1_MOUSE Ssb1 uc008vxg.1 uc008vxg.2 uc008vxg.3 uc008vxg.4 Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links the NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). Protein modification; protein ubiquitination. Component of the probable ECS(SPSB1) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB1 (By similarity). Interacts with CUL5, RNF7, ELOB and ELOC (By similarity). Directly interacts with MET tyrosine kinase domain in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction (PubMed:16369487). When phosphorylated, interacts with RASA1 without affecting its stability (By similarity). Interacts (via B30.2/SPRY domain) with PAWR; this interaction is direct and occurs in association with the Elongin BC complex (PubMed:16369487, PubMed:16498413, PubMed:20561531).Interacts with EPHB2 (By similarity). Interacts with NOS2 (PubMed:20603330). Q9D5L7; Q96IZ0: PAWR; Xeno; NbExp=2; IntAct=EBI-8821912, EBI-595869; Cytoplasm Cytoplasm, cytosol Note=Exhibits a diffuse cytosolic localization. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D5L7-1; Sequence=Displayed; Name=2; IsoId=Q9D5L7-2; Sequence=VSP_018612; The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). Essential for its ability to link NOS2 and the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). The B30.2/SPRY domain is involved in MET and PAWR binding. Belongs to the SPSB family. protein binding cytoplasm cytosol ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex proteasome-mediated ubiquitin-dependent protein catabolic process protein binding, bridging involved in substrate recognition for ubiquitination uc008vxg.1 uc008vxg.2 uc008vxg.3 uc008vxg.4 
ENSMUST00000038570.9 Nipsnap1 ENSMUST00000038570.9 nipsnap homolog 1 (from RefSeq NM_008698.3) ENSMUST00000038570.1 ENSMUST00000038570.2 ENSMUST00000038570.3 ENSMUST00000038570.4 ENSMUST00000038570.5 ENSMUST00000038570.6 ENSMUST00000038570.7 ENSMUST00000038570.8 NM_008698 Nipsnap1 Q5SVF7 Q5SVF7_MOUSE uc007hvk.1 uc007hvk.2 uc007hvk.3 Belongs to the NipSnap family. uc007hvk.1 uc007hvk.2 uc007hvk.3 
ENSMUST00000038574.7 Dhx29 ENSMUST00000038574.7 DExH-box helicase 29 (from RefSeq NM_172594.3) DHX29_MOUSE Dhx29 ENSMUST00000038574.1 ENSMUST00000038574.2 ENSMUST00000038574.3 ENSMUST00000038574.4 ENSMUST00000038574.5 ENSMUST00000038574.6 NM_172594 Q6PGC1 Q8BQJ4 Q8BT01 Q8C9B7 Q8C9H9 uc007rwx.1 uc007rwx.2 uc007rwx.3 ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit. Cytoplasm Belongs to the DEAD box helicase family. DEAH subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity translation initiation factor activity helicase activity ATP binding cytoplasm mitochondrion translation translational initiation eukaryotic 43S preinitiation complex hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ribosomal small subunit binding positive regulation of translational initiation uc007rwx.1 uc007rwx.2 uc007rwx.3 
ENSMUST00000038580.7 H2-M3 ENSMUST00000038580.7 histocompatibility 2, M region locus 3 (from RefSeq NM_013819.3) ENSMUST00000038580.1 ENSMUST00000038580.2 ENSMUST00000038580.3 ENSMUST00000038580.4 ENSMUST00000038580.5 ENSMUST00000038580.6 H-2M3 H2-M3 NM_013819 Q31093 Q31093_MOUSE uc008cmo.1 uc008cmo.2 uc008cmo.3 Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. negative regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity response to molecule of bacterial origin alpha-beta T cell activation involved in immune response peripheral B cell tolerance induction antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent positive regulation of tolerance induction positive regulation of T cell tolerance induction positive regulation of natural killer cell cytokine production immune response-inhibiting cell surface receptor signaling pathway receptor binding extracellular space early endosome plasma membrane immune response external side of plasma membrane membrane integral component of membrane negative regulation of angiogenesis MHC class Ib protein complex positive regulation of interferon-gamma production positive regulation of interleukin-12 production cis-Golgi network membrane negative regulation of T cell proliferation protection from natural killer cell mediated cytotoxicity peptide antigen binding CD8 receptor binding defense response to bacterium identical protein binding protein homodimerization activity positive regulation of nitric oxide biosynthetic process positive regulation of regulatory T cell differentiation negative regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity negative regulation of protein kinase B signaling positive regulation of macrophage cytokine production protein homotrimerization negative regulation of G0 to G1 transition positive regulation of endothelial cell apoptotic process positive regulation of cellular senescence negative regulation of dendritic cell differentiation uc008cmo.1 uc008cmo.2 uc008cmo.3 
ENSMUST00000038584.9 Tlk1 ENSMUST00000038584.9 tousled-like kinase 1, transcript variant 1 (from RefSeq NM_172664.3) ENSMUST00000038584.1 ENSMUST00000038584.2 ENSMUST00000038584.3 ENSMUST00000038584.4 ENSMUST00000038584.5 ENSMUST00000038584.6 ENSMUST00000038584.7 ENSMUST00000038584.8 NM_172664 Q8C0V0 TLK1_MOUSE uc008jzt.1 uc008jzt.2 uc008jzt.3 uc008jzt.4 Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity). Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation at Ser-743, potentially by CHEK1 (By similarity). Heterodimer with TLK2. Nucleus Ubiquitously expressed in all tissues examined. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Sequence=AAH51641.1; Type=Erroneous initiation; Evidence=; nucleotide binding regulation of chromatin assembly or disassembly protein kinase activity protein serine/threonine kinase activity ATP binding nucleus chromatin organization protein phosphorylation intracellular protein transport cellular response to DNA damage stimulus cell cycle chromosome segregation kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction uc008jzt.1 uc008jzt.2 uc008jzt.3 uc008jzt.4 
ENSMUST00000038598.3 Idi2 ENSMUST00000038598.3 isopentenyl-diphosphate delta isomerase 2 (from RefSeq NM_177197.5) ENSMUST00000038598.1 ENSMUST00000038598.2 Gm9745 IDI2_MOUSE NM_177197 Q4FZF0 Q8BFZ6 uc007pko.1 uc007pko.2 uc007pko.3 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Reaction=isopentenyl diphosphate = dimethylallyl diphosphate; Xref=Rhea:RHEA:23284, ChEBI:CHEBI:57623, ChEBI:CHEBI:128769; EC=5.3.3.2; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1. Peroxisome Belongs to the IPP isomerase type 1 family. isopentenyl-diphosphate delta-isomerase activity peroxisome lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process steroid metabolic process cholesterol metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process sterol biosynthetic process hydrolase activity isomerase activity negative regulation of cholesterol biosynthetic process isopentenyl diphosphate metabolic process metal ion binding dimethylallyl diphosphate biosynthetic process uc007pko.1 uc007pko.2 uc007pko.3 
ENSMUST00000038600.4 Mrps2 ENSMUST00000038600.4 mitochondrial ribosomal protein S2, transcript variant 1 (from RefSeq NM_080452.3) A2AK29 ENSMUST00000038600.1 ENSMUST00000038600.2 ENSMUST00000038600.3 NM_080452 Q3TMF8 Q924T2 RT02_MOUSE uc008iyi.1 uc008iyi.2 uc008iyi.3 Required for mitoribosome formation and stability, and mitochondrial translation. Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uS2 family. structural constituent of ribosome mitochondrion mitochondrial small ribosomal subunit ribosome translation small ribosomal subunit mitochondrial translation mitochondrial ribosome assembly uc008iyi.1 uc008iyi.2 uc008iyi.3 
ENSMUST00000038608.14 Mboat7 ENSMUST00000038608.14 membrane bound O-acyltransferase domain containing 7 (from RefSeq NM_029934.4) Bb1 ENSMUST00000038608.1 ENSMUST00000038608.10 ENSMUST00000038608.11 ENSMUST00000038608.12 ENSMUST00000038608.13 ENSMUST00000038608.2 ENSMUST00000038608.3 ENSMUST00000038608.4 ENSMUST00000038608.5 ENSMUST00000038608.6 ENSMUST00000038608.7 ENSMUST00000038608.8 ENSMUST00000038608.9 Leng4 Lpiat1 MBOA7_MOUSE Mboat7 NM_029934 Oact7 Q3UDM6 Q8CHK3 Q8R1P9 Q9CY76 uc009evq.1 uc009evq.2 uc009evq.3 Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1- acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:23097495, PubMed:23472195, PubMed:32253259). Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell (PubMed:23097495, PubMed:23472195). In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation (PubMed:32253259). Reaction=a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:33195, ChEBI:CHEBI:57287, ChEBI:CHEBI:57880, ChEBI:CHEBI:58342, ChEBI:CHEBI:64771; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33196; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn- glycero-3-phospho-(1D-myo-inositol) = 1-octadecanoyl-2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo- inositol) + CoA; Xref=Rhea:RHEA:36835, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74243, ChEBI:CHEBI:133606; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36836; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3- phospho-(1D-myo-inositol) = a 1-acyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:37015, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:64771, ChEBI:CHEBI:75243; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37016; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn- glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35999, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36000; Evidence=; Lipid metabolism; phospholipid metabolism. Interacts with SPTSSA; the interaction facilitates MBOAT7 location to mitochondria-associated membranes (MAMs). Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Localized in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Knockout mice die within a month and show atrophy of the cerebral cortex and hippocampus. Embryos at 18.5 dpc have a forebrain smaller in size and show disordered cortical lamination and delayed neuronal migration in the cortex (PubMed:23097495, PubMed:23472195). Mice with conditional knockout in hepatocyte develop hepatic steatosis spontaneously, and hepatic fibrosis on high fat diet feeding (PubMed:32253259). Belongs to the membrane-bound acyltransferase family. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phospholipid metabolic process phospholipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups ventricular system development layer formation in cerebral cortex ER-mitochondrion membrane contact site phosphatidylinositol metabolic process lysophospholipid acyltransferase activity uc009evq.1 uc009evq.2 uc009evq.3 
ENSMUST00000038614.12 Ypel3 ENSMUST00000038614.12 yippee like 3, transcript variant 2 (from RefSeq NM_025347.3) ENSMUST00000038614.1 ENSMUST00000038614.10 ENSMUST00000038614.11 ENSMUST00000038614.2 ENSMUST00000038614.3 ENSMUST00000038614.4 ENSMUST00000038614.5 ENSMUST00000038614.6 ENSMUST00000038614.7 ENSMUST00000038614.8 ENSMUST00000038614.9 NM_025347 P61237 Q71E85 Q9BSJ4 Q9CQB6 Q9D0U3 Suap YPEL3_MOUSE uc009jsp.1 uc009jsp.2 uc009jsp.3 Involved in proliferation and apoptosis in myeloid precursor cells. Nucleus, nucleolus Widely expressed. Strongly expressed in heart, brain, testis, lung, spleen, liver, kidney and myeloid cells. Up-regulated after the removal of interleukin 3 and exposure to granulocyte colony stimulating factor. Probably ubiquitinated leading to its degradation by the proteasome. Belongs to the yippee family. Sequence=AAH09171.4; Type=Erroneous initiation; Evidence=; molecular_function cellular_component nucleus nucleolus apoptotic process metal ion binding positive regulation of cellular senescence uc009jsp.1 uc009jsp.2 uc009jsp.3 
ENSMUST00000038618.13 Ltbp4 ENSMUST00000038618.13 latent transforming growth factor beta binding protein 4, transcript variant 1 (from RefSeq NM_175641.2) E9QPD9 ENSMUST00000038618.1 ENSMUST00000038618.10 ENSMUST00000038618.11 ENSMUST00000038618.12 ENSMUST00000038618.2 ENSMUST00000038618.3 ENSMUST00000038618.4 ENSMUST00000038618.5 ENSMUST00000038618.6 ENSMUST00000038618.7 ENSMUST00000038618.8 ENSMUST00000038618.9 LTBP4_MOUSE NM_175641 Q8K4G0 Q8K4G1 uc009fvt.1 uc009fvt.2 uc009fvt.3 uc009fvt.4 Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex. Interacts with LTBP1 and TGFB1. Interacts with EFEMP2; this interaction promotes fibrillar deposition of EFEMP2 (PubMed:25713297). Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=LTBP4L; IsoId=Q8K4G1-1; Sequence=Displayed; Name=2; Synonyms=LTBP4S; IsoId=Q8K4G1-2; Sequence=VSP_009248, VSP_009250; Name=3; IsoId=Q8K4G1-3; Sequence=VSP_009249; Contains hydroxylated asparagine residues. Mice reveal significant disruption of elastic fibers in multiple tissues. They develop pulmonary septation defects, rectal prolapse, colorectal adenomas, and dilated cardiomyopathy. They survive up to six months (mid-adult age) without major clinical symptoms. [Isoform 3]: Sequence incomplete. Belongs to the LTBP family. extracellular matrix structural constituent calcium ion binding extracellular region extracellular space transforming growth factor beta receptor signaling pathway growth factor binding regulation of proteolysis extracellular matrix hormone secretion transforming growth factor beta binding uc009fvt.1 uc009fvt.2 uc009fvt.3 uc009fvt.4 
ENSMUST00000038626.10 Mpv17l2 ENSMUST00000038626.10 MPV17 mitochondrial membrane protein-like 2 (from RefSeq NM_183170.2) ENSMUST00000038626.1 ENSMUST00000038626.2 ENSMUST00000038626.3 ENSMUST00000038626.4 ENSMUST00000038626.5 ENSMUST00000038626.6 ENSMUST00000038626.7 ENSMUST00000038626.8 ENSMUST00000038626.9 Fksg24 M17L2_MOUSE NM_183170 Q3THH2 Q80UR1 Q8VIK2 uc009mbl.1 uc009mbl.2 uc009mbl.3 Required for the assembly and stability of the mitochondrial ribosome (By similarity). Is a positive regulator of mitochondrial protein synthesis (By similarity). Interacts with the large mitochondrial ribosomal subunit. Membrane ; Multi-pass membrane protein Mitochondrion inner membrane Belongs to the peroxisomal membrane protein PXMP2/4 family. molecular_function cytoplasm mitochondrion mitochondrial inner membrane mitochondrial large ribosomal subunit membrane integral component of membrane mitochondrial ribosome assembly positive regulation of mitochondrial translation uc009mbl.1 uc009mbl.2 uc009mbl.3 
ENSMUST00000038627.9 Zfp91 ENSMUST00000038627.9 zinc finger protein 91 (from RefSeq NM_053009.3) ENSMUST00000038627.1 ENSMUST00000038627.2 ENSMUST00000038627.3 ENSMUST00000038627.4 ENSMUST00000038627.5 ENSMUST00000038627.6 ENSMUST00000038627.7 ENSMUST00000038627.8 NM_053009 Pzf Q3TEQ3 Q3UH61 Q62509 Q62511 Q6P219 Q6PG06 Q8BPY3 Q8C2B4 Q8CDZ3 ZFP91_MOUSE uc008gup.1 uc008gup.2 uc008gup.3 uc008gup.4 The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. The homologous human protein has been shown to function as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. A read-through transcript variant composed of Zfp91 and the downstream Cntf gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. A Zfp91-related pseudogene has also been identified on chromosome 17. [provided by RefSeq, Oct 2010]. ##Evidence-Data-START## Transcript exon combination :: AK147560.1, AK147502.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF- kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with MAP3K14/NIK. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q62511-1; Sequence=Displayed; Name=2; IsoId=Q62511-2; Sequence=VSP_025759, VSP_025760; Found in all the examined tissues including brain, heart, kidney, lung, liver, spleen, thymus, skeletal muscle, ovary and testis. In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC26394.1; Type=Frameshift; Evidence=; Sequence=BAC34808.1; Type=Erroneous initiation; Evidence=; Sequence=BAC40660.1; Type=Frameshift; Evidence=; RNA polymerase II core promoter sequence-specific DNA binding nucleic acid binding ubiquitin-protein transferase activity nucleus nucleolus activation of NF-kappaB-inducing kinase activity regulation of gene expression protein ubiquitination transferase activity metal ion binding protein K63-linked ubiquitination histone methyltransferase complex uc008gup.1 uc008gup.2 uc008gup.3 uc008gup.4 
ENSMUST00000038644.5 Rangrf ENSMUST00000038644.5 RAN guanine nucleotide release factor, transcript variant 2 (from RefSeq NM_021329.3) ENSMUST00000038644.1 ENSMUST00000038644.2 ENSMUST00000038644.3 ENSMUST00000038644.4 MOG1_MOUSE Mog1 NM_021329 Q9CWZ0 Q9JIB0 Rangnrf uc007jor.1 uc007jor.2 uc007jor.3 uc007jor.4 May regulate the intracellular trafficking of RAN (PubMed:10811801, PubMed:11733047). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:10811801, PubMed:11733047). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (By similarity). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830). Monomer (Probable). Interacts with RAN, both RAN-GTP and RAN- GDP (PubMed:10811801). Competes with RCC1 for a common binding site on RAN and thereby inhibits RCC1-mediated nucleotide exchange (By similarity). Forms a complex with RAN-GTP and RANBP1 (PubMed:10811801). Interacts with the cytoplasmic loop 2 of SCN5A (PubMed:18184654). Nucleus toplasm, perinuclear region Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Shuttles between the nucleus and cytoplasm. Highgly abundant in cardiac cells. Expressed in testis during prepubertal development. Down-regulated in mice lacking Ovol1. Belongs to the MOG1 family. regulation of membrane depolarization guanyl-nucleotide exchange factor activity Ran guanyl-nucleotide exchange factor activity nucleus nucleoplasm cytoplasm rough endoplasmic reticulum cytosol plasma membrane caveola ER to Golgi vesicle-mediated transport nucleocytoplasmic transport Ran GTPase binding intercalated disc protein transport membrane sodium channel regulator activity protein exit from endoplasmic reticulum regulation of membrane potential ion channel binding perinuclear region of cytoplasm regulation of microtubule nucleation by Ran protein signal transduction regulation of bundle of His cell action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of membrane depolarization during cardiac muscle cell action potential regulation of sodium ion transmembrane transport positive regulation of protein localization to plasma membrane positive regulation of protein localization to cell surface regulation of sodium ion transmembrane transporter activity uc007jor.1 uc007jor.2 uc007jor.3 uc007jor.4 
ENSMUST00000038648.11 Nek11 ENSMUST00000038648.11 NIMA (never in mitosis gene a)-related expressed kinase 11 (from RefSeq NM_172461.4) E9QNC3 ENSMUST00000038648.1 ENSMUST00000038648.10 ENSMUST00000038648.2 ENSMUST00000038648.3 ENSMUST00000038648.4 ENSMUST00000038648.5 ENSMUST00000038648.6 ENSMUST00000038648.7 ENSMUST00000038648.8 ENSMUST00000038648.9 NEK11_MOUSE NM_172461 Nek11 Q8BLS6 Q8BW62 Q8C0Q4 uc009rhy.1 uc009rhy.2 uc009rhy.3 uc009rhy.4 Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Autorepressed by intramolecular binding of the C- terminus which dissociates following phosphorylation by NEK2. Activated in response to DNA damage. Inhibited by zinc. Interacts with NEK2. Nucleus Nucleus, nucleolus Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells. Phosphorylated by NEK2. Phosphorylation at Ser-274 is important for its activation. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleoplasm nucleolus cytoplasm centrosome protein phosphorylation cell cycle chromosome segregation kinase activity phosphorylation histone phosphorylation transferase activity intra-S DNA damage checkpoint intracellular signal transduction mitotic cell cycle phase transition metal ion binding regulation of mitotic cell cycle phase transition uc009rhy.1 uc009rhy.2 uc009rhy.3 uc009rhy.4 
ENSMUST00000038661.8 Slc25a34 ENSMUST00000038661.8 solute carrier family 25, member 34 (from RefSeq NM_001013780.1) A2ADF7 ENSMUST00000038661.1 ENSMUST00000038661.2 ENSMUST00000038661.3 ENSMUST00000038661.4 ENSMUST00000038661.5 ENSMUST00000038661.6 ENSMUST00000038661.7 Gm1369 NM_001013780 Q5FW51 S2534_MOUSE uc008vox.1 uc008vox.2 uc008vox.3 uc008vox.4 Putative antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria. Reaction=a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in); Xref=Rhea:RHEA:76595, ChEBI:CHEBI:16189, ChEBI:CHEBI:28965; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2ADF7-1; Sequence=Displayed; Name=2; IsoId=A2ADF7-2; Sequence=VSP_026235, VSP_026236; Belongs to the mitochondrial carrier (TC 2.A.29) family. blastocyst hatching mitochondrion mitochondrial inner membrane membrane integral component of membrane uc008vox.1 uc008vox.2 uc008vox.3 uc008vox.4 
ENSMUST00000038665.6 Ptchd1 ENSMUST00000038665.6 patched domain containing 1 (from RefSeq NM_001093750.1) B1AZU9 ENSMUST00000038665.1 ENSMUST00000038665.2 ENSMUST00000038665.3 ENSMUST00000038665.4 ENSMUST00000038665.5 NM_001093750 PTHD1_MOUSE Q14B62 Q14B63 Q8BZA5 ptchd1 uc009urw.1 uc009urw.2 uc009urw.3 Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, generation of sleep rhythms, sensorimotor processing and attention. Q14B62; Q62108: Dlg4; NbExp=8; IntAct=EBI-27105784, EBI-300895; Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14B62-1; Sequence=Displayed; Name=2; IsoId=Q14B62-2; Sequence=VSP_023514; Broadly expressed in the brain (PubMed:20844286). Selectively expressed in the thalamic reticular nucleus (TRN) in early development and continues to be enriched in this structure throughout adult life (PubMed:27007844). Widely expressed in the developing brain from 9.5 day post coitum (dpc) to postnatal day 1 (P1) (PubMed:20844286). Specifically expressed in the thalamic reticular nucleus (TRN) at birth. Expressed in the striatum, cortex and cerebellum by P15 onwards (PubMed:27007844). Mice show decreased spindles and sleep fragmentation, learning defects, hyper-aggressive behavior and motor defects. Selective deletion in the thalamic reticular nucleus (TRN) leads to attention deficits and hyperactivity. Defects are probably due to dcreased TRN activity through mechanisms involving small conductance calcium-dependent potassium currents (SK). Belongs to the patched family. molecular_function plasma membrane smoothened signaling pathway membrane integral component of membrane thalamus development social behavior cognition uc009urw.1 uc009urw.2 uc009urw.3 
ENSMUST00000038671.10 Kri1 ENSMUST00000038671.10 KRI1 homolog (from RefSeq NM_145416.3) ENSMUST00000038671.1 ENSMUST00000038671.2 ENSMUST00000038671.3 ENSMUST00000038671.4 ENSMUST00000038671.5 ENSMUST00000038671.6 ENSMUST00000038671.7 ENSMUST00000038671.8 ENSMUST00000038671.9 F6WIU1 F6WIU1_MOUSE Kri1 NM_145416 uc012gpc.1 uc012gpc.2 Belongs to the KRI1 family. uc012gpc.1 uc012gpc.2 
ENSMUST00000038675.7 Mrpl23 ENSMUST00000038675.7 mitochondrial ribosomal protein L23, transcript variant 2 (from RefSeq NM_011288.3) ENSMUST00000038675.1 ENSMUST00000038675.2 ENSMUST00000038675.3 ENSMUST00000038675.4 ENSMUST00000038675.5 ENSMUST00000038675.6 L23mrp NM_011288 O35972 Q78E46 RM23_MOUSE uc009kny.1 uc009kny.2 uc009kny.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uL23 family. fibrillar center structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation mitochondrial translation uc009kny.1 uc009kny.2 uc009kny.3 
ENSMUST00000038676.7 Cpz ENSMUST00000038676.7 carboxypeptidase Z (from RefSeq NM_153107.2) CBPZ_MOUSE ENSMUST00000038676.1 ENSMUST00000038676.2 ENSMUST00000038676.3 ENSMUST00000038676.4 ENSMUST00000038676.5 ENSMUST00000038676.6 G3X945 NM_153107 Q8R4V4 uc008xdt.1 uc008xdt.2 uc008xdt.3 Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Inhibited by 2-mercaptomethyl-3- guanidinoethylthiopropanoic acid (MGTA) and guanidinoethylmercaptosuccinic acid (GEMSA). Inhibited by chelating agents such as EDTA and EGTA (By similarity). Secreted, extracellular space, extracellular matrix Belongs to the peptidase M14 family. carboxypeptidase activity metallocarboxypeptidase activity extracellular region extracellular space proteolysis peptide metabolic process peptidase activity metallopeptidase activity zinc ion binding Wnt signaling pathway protein processing hydrolase activity extracellular matrix metal ion binding uc008xdt.1 uc008xdt.2 uc008xdt.3 
ENSMUST00000038677.5 Rrp12 ENSMUST00000038677.5 ribosomal RNA processing 12 homolog (from RefSeq NM_199447.2) ENSMUST00000038677.1 ENSMUST00000038677.2 ENSMUST00000038677.3 ENSMUST00000038677.4 Kiaa0690 NM_199447 Q6P5B0 Q7TMI5 Q80TU2 RRP12_MOUSE uc008hmk.1 uc008hmk.2 uc008hmk.3 uc008hmk.4 Nucleus, nucleolus Nucleus membrane ; Single-pass membrane protein Belongs to the RRP12 family. Sequence=BAC65628.3; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; nucleus nucleolus biological_process membrane integral component of membrane nuclear membrane uc008hmk.1 uc008hmk.2 uc008hmk.3 uc008hmk.4 
ENSMUST00000038684.6 Fhl3 ENSMUST00000038684.6 four and a half LIM domains 3, transcript variant 7 (from RefSeq NR_184997.1) A6H6N4 ENSMUST00000038684.1 ENSMUST00000038684.2 ENSMUST00000038684.3 ENSMUST00000038684.4 ENSMUST00000038684.5 FHL3_MOUSE NR_184997 Q9JLP5 Q9R059 Q9WUH3 uc008uqv.1 uc008uqv.2 uc008uqv.3 uc008uqv.4 Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. Interacts with SOX15; the interaction recruits FHL3 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. Q9R059; P43267: Sox15; NbExp=7; IntAct=EBI-7332617, EBI-7332587; Nucleus Cytoplasm Expressed in myogenic progenitor cells (at protein level) (PubMed:17363903). Expressed in skeletal striated muscle and the heart (PubMed:10906474, PubMed:17363903). Expressed to a lesser extent, in lung, and kidney (PubMed:10906474). Expressed in skin and skeletal muscles such as the masseter, tongue, tibialis anterior and plantar muscles (PubMed:10049693). Expressed ubiquitously at low levels during embryonic development. stress fiber actin binding protein binding nucleus Z disc actin cytoskeleton organization metal ion binding uc008uqv.1 uc008uqv.2 uc008uqv.3 uc008uqv.4 
ENSMUST00000038690.6 AW209491 ENSMUST00000038690.6 expressed sequence AW209491, transcript variant 1 (from RefSeq NM_134067.4) CG025_MOUSE ENSMUST00000038690.1 ENSMUST00000038690.2 ENSMUST00000038690.3 ENSMUST00000038690.4 ENSMUST00000038690.5 NM_134067 Q8BP59 Q8BSU5 Q91WD4 uc007pnn.1 uc007pnn.2 uc007pnn.3 uc007pnn.4 Belongs to the UPF0415 family. Sequence=BAC36926.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc007pnn.1 uc007pnn.2 uc007pnn.3 uc007pnn.4 
ENSMUST00000038692.6 Mgat4d ENSMUST00000038692.6 MGAT4 family, member C (from RefSeq NM_026233.2) E2F697 E9QM08 ENSMUST00000038692.1 ENSMUST00000038692.2 ENSMUST00000038692.3 ENSMUST00000038692.4 ENSMUST00000038692.5 MGT4D_MOUSE Mgat4d NM_026233 Q9D4R2 uc009mkb.1 uc009mkb.2 uc009mkb.3 [Isoform 2]: May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis. Isoform 2 self-associates; specifically in the endoplasmic reticulum prior to its translocation to the Golgi. Isoform 1 and isoform 2 interact with MGAT1, MGAT3 and MAN2A2; isoform 2 interacts specifically with MGAT1 in the Golgi. [Isoform 2]: Endoplasmic reticulum membrane ; Single-pass type II membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type II membrane protein Golgi apparatus membrane ; Single-pass type II membrane protein [Isoform 1]: Golgi apparatus membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=GnT1IP-S; IsoId=Q9D4R2-1; Sequence=Displayed; Name=2; Synonyms=GnT1IP-L; IsoId=Q9D4R2-2; Sequence=VSP_058925; Isoform 1 and isoform 2 are specifically expressed in testis. Isoform 2 is expressed in spermatocytes but not in spermatids. Isoform 1 is expressed in spermatids. Expression of isoform 1 and isoform 2 is up- regulated in testis at postnatal day 17; isoform 1 maintains similar expression levels until the adult; expression of isoform 2 peaks at postnatal day 22 and is barely detected in the adult. Isoform 2 is N-glycosylated; consisting of high-mannose and/or hybrid glycans. For isoform 1 inhibition of MGAT1 activity is demonstrated in vitro upon forced membrane-association. Its rat ortholog is the most abundant protein in testis Golgi preparations. Belongs to the glycosyltransferase 54 family. Name=Functional Glycomics Gateway - GTase; Note=GlcNAcT VI; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_582"; Golgi membrane endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus Golgi stack protein N-linked glycosylation spermatogenesis acetylglucosaminyltransferase activity membrane integral component of membrane cell differentiation endoplasmic reticulum-Golgi intermediate compartment membrane negative regulation of protein glycosylation uc009mkb.1 uc009mkb.2 uc009mkb.3 
ENSMUST00000038693.8 Cldn22 ENSMUST00000038693.8 claudin 22 (from RefSeq NM_029383.2) CLD22_MOUSE ENSMUST00000038693.1 ENSMUST00000038693.2 ENSMUST00000038693.3 ENSMUST00000038693.4 ENSMUST00000038693.5 ENSMUST00000038693.6 ENSMUST00000038693.7 NM_029383 Q9D7U6 uc012gdq.1 uc012gdq.2 uc012gdq.3 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the Wwc2 gene (GeneID: 52357) on the opposite strand. [provided by RefSeq, Aug 2010]. ##Evidence-Data-START## Transcript is intronless :: AK008821.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Belongs to the claudin family. molecular_function structural molecule activity cellular_component plasma membrane bicellular tight junction biological_process membrane integral component of membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding uc012gdq.1 uc012gdq.2 uc012gdq.3 
ENSMUST00000038695.6 Kcna2 ENSMUST00000038695.6 potassium voltage-gated channel, shaker-related subfamily, member 2 (from RefSeq NM_008417.5) B2RS05 ENSMUST00000038695.1 ENSMUST00000038695.2 ENSMUST00000038695.3 ENSMUST00000038695.4 ENSMUST00000038695.5 KCNA2_MOUSE NM_008417 P15386 P63141 Q02010 Q8C8W4 uc008qws.1 uc008qws.2 uc008qws.3 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:12527813, PubMed:21233214). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:20696761). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:23864368). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:23864368). Contributes to the regulation of action potentials in neurons (PubMed:12527813, PubMed:17925011). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (PubMed:17634333, PubMed:17925011). Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity). KCNA2-containing channels play a role in GABAergic transmission from basket cells to Purkinje cells in the cerebellum, and thereby play an import role in motor coordination (PubMed:20696761). Plays a role in the induction of long- term potentiation of neuron excitability in the CA3 layer of the hippocampus (PubMed:23981714). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (PubMed:21233214). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (PubMed:17925011). Inhibited by 4-aminopyridine (4-AP), dendrotoxin (DTX) and charybdotoxin (CTX), but not by tetraethylammonium (TEA) (By similarity). Inhibited by tityustoxin-K alpha (TsTX-Kalpha), a toxin that is highly specific for KCNA2 (By similarity). Inhibited by maurotoxin (PubMed:12527813). Inhibited by kappaM conotoxins kappaM- RIIIJ and kappaM-RIIIK (By similarity). Kinetic parameters: Note=Homotetrameric channels activate rapidly, i.e within a few msec, but inactivation is very slow, with only a marginal decrease in conductance over several seconds. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system, post-translational modifications and the presence or absence of ancillary subunits. For the activation of homotetrameric channels expressed in Chinese hamster ovary (CHO) cells, the voltage at half- maximal amplitude is about -37 mV. ; Homotetramer and heterotetramer with other channel-forming alpha subunits, such as KCNA1, KCNA4, KCNA5, KCNA6 and KCNA7 (PubMed:8361541, PubMed:9852577, PubMed:23864368). Channel activity is regulated by interaction with beta subunits, including KCNAB1 and KCNAB2 (By similarity). Identified in a complex with KCNA1 and KCNAB2 (By similarity). Identified in a complex with KCNA5 and KCNAB1 (By similarity). Identified in a complex with KCNA4 and FYN (By similarity). Interacts with PTK2B (By similarity). Interacts (via C- terminus) with CTTN (By similarity). Interacts with ADAM22 (By similarity). Interacts with CNTNAP2 (By similarity). Interacts (via C- terminus) with the PDZ domains of DLG1, DLG2 and DLG4 (By similarity). Interacts (via N-terminal cytoplasmic domain) with RHOA (GTP-bound form); this regulates channel activity by reducing location at the cell surface in response to CHRM1 activation (PubMed:9635436). Interacts with DRD2 (PubMed:21233214). Interacts with SIGMAR1; cocaine consumption leads to increased interaction (PubMed:23332758). Interacts with ADAM11 (PubMed:26269648). P63141; Q60598: Cttn; NbExp=3; IntAct=EBI-644033, EBI-397955; P63141; O55242: Sigmar1; NbExp=3; IntAct=EBI-644033, EBI-1557700; P63141; Q9R0C9: Sigmar1; Xeno; NbExp=3; IntAct=EBI-644033, EBI-1557826; Cell membrane ulti-pass membrane protein Membrane ll projection, axon napse Endoplasmic reticulum membrane Cell projection, lamellipodium membrane Synapse, synaptosome Presynaptic cell membrane Cell projection, dendrite Perikaryon ll junction, paranodal septate junction Note=KCNA2 by itself is detected both at the endoplasmic reticulum and at the cell membrane. Coexpression with KCNA4 or with beta subunits promotes expression at the cell membrane. Coexpression with KCNA1 inhibits cell surface expression (By similarity). Cocaine-induced interaction with SIGMAR1 increases expression at the cell surface (PubMed:23332758). In myelinated peripheral axons, clustered in the juxtaparadonal region and at an internodal line located along the mesaxon and below the Schmidt- Lanterman incisures (PubMed:25378149). Detected in brain (PubMed:17634333). Detected in cerebellum (PubMed:20696761). Detected in mitral cells in the olfactory bulb (PubMed:8046438). Detected in cochlea (PubMed:23864368). Detected in cerebellum, particularly in the basket cell axon plexus and in the terminal regions around Purkinje cells (at protein level) (PubMed:8361541, PubMed:8046438, PubMed:18760366, PubMed:26269648). Detected in juxtaparanodal regions in sciatic nerve (PubMed:22649228). Detected in Schwann cells from sciatic nerve (PubMed:9852577). Detected in dopamine neurons in substantia nigra (PubMed:21233214). Detected in large myelinated fibers in juxtaparanodes in the CA3 and CA1 areas of the hippocampus (PubMed:8046438, PubMed:18760366). Detected in brain, in punctae on fiber tracts in brain stem and spinal cord, and on axons in the juxtaparanodal regions of the node of Ranvier (at protein level) (PubMed:8361541). Detected in dopamine neurons in the midbrain (PubMed:21233214). Detected at low levels in brainstem from neonates; increases tenfold during the first 29 days after birth. The cytoplasmic N-terminus is important for tetramerization. Interactions between the different subunits modulate the gating characteristics (By similarity). Besides, the cytoplasmic N-terminal domain mediates interaction with RHOA and thus is required for RHOA- mediated endocytosis (By similarity). The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. Phosphorylated on tyrosine residues; phosphorylation increases in response to ischemia (By similarity). Phosphorylated on tyrosine residues by activated PTK2B/PYK2 (By similarity). Phosphorylation on tyrosine residues suppresses ion channel activity (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation; this abolishes interaction with CTTN. This is probably due to endocytosis of the phosphorylated channel subunits (By similarity). Phosphorylated on serine residues in response to increased cAMP levels; phosphorylation is apparently not catalyzed by PKA (By similarity). N-glycosylated, with complex, sialylated N-glycans. Pups are born at the expected Mendelian rate and appear normal during the first 14 days after birth. Starting at 14 to 17 days after birth, mice exhibit susceptibility to generalized seizures, followed by full tonic extension, which in mice often results in fatal apne. The average lifespan is 17 days; none survive more than 28 days (PubMed:17925011, PubMed:17634333). At P17 seizures are very rare and abnormal electroencephalograph activity is only present during the seizure. P17 pups have significantly less non-rapid eye movement (NREM) sleep (-23%) and significantly more waking (+21%) than wild-type siblings with no change in rapid eye movement (REM) sleep time. The decrease in NREM sleep is due to an increase in the number of waking episodes, with no change in number or duration of sleep episodes (PubMed:17925011). Auditory neurons from the medial nucleus of the trapezoid body in brain stem are hypoexcitable and fire fewer action potentials than wild-type neurons with significantly smaller threshold current amplitudes (PubMed:17634333). In the inner ear, spiral ganglion neurons display a hyperpolarized resting membrane potential, increased excitability and increased outward potassium currents; this might be because normally channels there are heterotetramers formed by KCNA2 and KCNA4, so the loss of KCNA2 changes channel characteristics (PubMed:23864368). Mutagenesis with N-ethyl-N-nitrosourea (ENU) lead to the discovery of the Pingu (Pgu) phenotype. At P21, heterozygous mice are clearly smaller than wild-type and have abnormal gait with a higher stance and splayed hind limbs. Homozygous mice are even smaller, and about half of them die between P15 and P35. Mutant mice have difficulty staing on a rotating rod and perform poorly in a beam-walking test, where they display flattened posture, severe tremors, myoclonic jerks and ataxic movement. These symptoms are alleviated by a drug used to treat cerebellar ataxia. Measurements with Purkinje cells from cerebellar brain slices show increased frequency and amplitude of spontaneous inhibitory postsynaptic currents. The delay or D-type current observed in hippocampus pyramidal neurons is probably mediated by potassium channels containing KCNA2 plus KCNA1 or other family members. It is activated at about -50 mV, i.e. below the action potential threshold, and is characterized by slow inactivation, extremely slow recovery from inactivation, sensitivity to dendrotoxin (DTX) and to 4-aminopyridine (4-AP). Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity protein binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex regulation of dopamine secretion outward rectifier potassium channel activity membrane integral component of membrane neuronal action potential sensory perception of pain kinesin binding optic nerve structural organization lamellipodium cell junction axon dendrite lamellipodium membrane neuronal cell body membrane paranodal junction potassium channel complex regulation of ion transmembrane transport presynaptic membrane cell projection neuron projection perikaryon axon terminus juxtaparanode region of axon calyx of Held regulation of circadian sleep/wake cycle, non-REM sleep synapse protein oligomerization protein homooligomerization transmembrane transport potassium ion transmembrane transport integral component of presynaptic membrane uc008qws.1 uc008qws.2 uc008qws.3 
ENSMUST00000038696.12 Ppp1r9b ENSMUST00000038696.12 protein phosphatase 1, regulatory subunit 9B (from RefSeq NM_172261.3) ENSMUST00000038696.1 ENSMUST00000038696.10 ENSMUST00000038696.11 ENSMUST00000038696.2 ENSMUST00000038696.3 ENSMUST00000038696.4 ENSMUST00000038696.5 ENSMUST00000038696.6 ENSMUST00000038696.7 ENSMUST00000038696.8 ENSMUST00000038696.9 NEB2_MOUSE NM_172261 Q6R891 Q8K0X7 uc007kzr.1 uc007kzr.2 uc007kzr.3 uc007kzr.4 Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross- linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G- protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1. Required for hepatocyte growth factor (HGF)-induced cell migration (By similarity). Possibly exists as a homodimer, homotrimer or a homotetramer. Interacts with F-actin, PPP1CA, neurabin-1, TGN38 and D(2) dopamine receptor. Interacts with RGS1, RGS2, RGS4, RGS19 and ADRA1B, ADRA2A, ADRA2B, ADRA2C, CDKN2A, PPP1R2, RASGFR1 and TIAM1. Interacts (via C- terminus) with SPATA13 (via C-terminal tail) (By similarity). Interacts with DCLK2. Interacts with ADRA2B (By similarity). Cytoplasm, cytoskeleton Nucleus Postsynaptic density Cell junction, adherens junction Cell projection, dendritic spine Cytoplasm Cell membrane Cell projection, lamellipodium Cell projection, filopodium Cell projection, ruffle membrane Note=Enriched at synapse and cadherin-based cell-cell adhesion sites. In neurons, both cytosolic and membrane-associated, and highly enriched in the postsynaptic density apposed to exitatory synapses (By similarity). Colocalizes with PPP1R2 at actin-rich adherens junctions in epithelial cells and in dendritic spines. Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6R891-1; Sequence=Displayed; Name=2; IsoId=Q6R891-2; Sequence=VSP_017674, VSP_017675; The PP1 binding region is natively unstructured, upon PP1 binding, it acquires structure, blocks a substrate-binding site, and restricts PP1 phosphatase specificity to a subset of substrates. Stimulation of D1 (but not D2) dopamine receptors induces Ser-94 phosphorylation. Dephosphorylation of Ser-94 is mediated mainly by PP1 and to a lesser extent by PP2A. Phosphorylation of spinophilin disrupts its association with F-actin, but does not affect its binding to PP1 (By similarity). regulation of protein phosphorylation response to amphetamine developmental process involved in reproduction actin binding protein kinase activity protein phosphatase inhibitor activity protein binding nucleus nucleoplasm cytoplasm cytoskeleton plasma membrane adherens junction protein phosphorylation actin filament organization multicellular organism development nervous system development aging learning protein C-terminus binding protein phosphatase 1 binding response to organonitrogen compound postsynaptic density response to organic cyclic compound actin cytoskeleton membrane dendrite development cell migration calcium-mediated signaling kinase binding hippocampus development cerebral cortex development lamellipodium actin cytoskeleton organization actin filament depolymerization cell junction cell differentiation filopodium negative regulation of cell growth dendrite growth cone cortical actin cytoskeleton neuron projection development D2 dopamine receptor binding response to estradiol negative regulation of phosphoprotein phosphatase activity ruffle membrane dendritic spine membrane response to prostaglandin E response to nicotine cellular response to drug response to immobilization stress regulation of cell proliferation response to drug cell projection neuron projection neuronal cell body dendritic spine response to amino acid ion channel binding dendritic spine neck dendritic spine head macromolecular complex binding synapse filopodium assembly response to steroid hormone modulation of synaptic transmission actin filament binding male mating behavior reproductive system development cellular response to morphine cellular response to epidermal growth factor stimulus cellular response to estradiol stimulus cellular response to organic cyclic compound response to clozapine cellular response to peptide positive regulation of protein localization to plasma membrane protein localization to actin cytoskeleton positive regulation of cellular protein localization positive regulation of protein localization to actin cortical patch response to kainic acid response to L-phenylalanine derivative protein localization to cell periphery cytoplasmic side of dendritic spine plasma membrane regulation of opioid receptor signaling pathway uc007kzr.1 uc007kzr.2 uc007kzr.3 uc007kzr.4 
ENSMUST00000038699.13 Ap5z1 ENSMUST00000038699.13 adaptor-related protein complex 5, zeta 1 subunit (from RefSeq NM_172725.2) AP5Z1_MOUSE ENSMUST00000038699.1 ENSMUST00000038699.10 ENSMUST00000038699.11 ENSMUST00000038699.12 ENSMUST00000038699.2 ENSMUST00000038699.3 ENSMUST00000038699.4 ENSMUST00000038699.5 ENSMUST00000038699.6 ENSMUST00000038699.7 ENSMUST00000038699.8 ENSMUST00000038699.9 Kiaa0415 NM_172725 Q3U829 Q3UJJ0 Q63ZW8 Q8BS06 Q8C488 uc009aiq.1 uc009aiq.2 uc009aiq.3 As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Interacts with ZFYVE26 and SPG11 (By similarity). Cytoplasm Nucleus Sequence=BAC30747.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; double-strand break repair via homologous recombination molecular_function nucleus nucleoplasm cytoplasm DNA repair cellular response to DNA damage stimulus protein transport endosomal transport nuclear speck AP-5 adaptor complex uc009aiq.1 uc009aiq.2 uc009aiq.3 
ENSMUST00000038701.8 Zfp324 ENSMUST00000038701.8 zinc finger protein 324, transcript variant 1 (from RefSeq NM_178732.4) ENSMUST00000038701.1 ENSMUST00000038701.2 ENSMUST00000038701.3 ENSMUST00000038701.4 ENSMUST00000038701.5 ENSMUST00000038701.6 ENSMUST00000038701.7 NM_178732 Q78F42 Q78F42_MOUSE Zfp324 uc009fer.1 uc009fer.2 uc009fer.3 Nucleus molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc009fer.1 uc009fer.2 uc009fer.3 
ENSMUST00000038709.14 Cybc1 ENSMUST00000038709.14 cytochrome b 245 chaperone 1, transcript variant 1 (from RefSeq NM_144832.2) A2AN24 A2AN25 CYBC1_MOUSE Cybc1 ENSMUST00000038709.1 ENSMUST00000038709.10 ENSMUST00000038709.11 ENSMUST00000038709.12 ENSMUST00000038709.13 ENSMUST00000038709.2 ENSMUST00000038709.3 ENSMUST00000038709.4 ENSMUST00000038709.5 ENSMUST00000038709.6 ENSMUST00000038709.7 ENSMUST00000038709.8 ENSMUST00000038709.9 Eros NM_144832 Q3TYS2 Q8VD13 uc007mvn.1 uc007mvn.2 uc007mvn.3 uc007mvn.4 Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (By similarity). Controls the phagocyte respiratory burst and is essential for innate immunity (PubMed:28351984). Interacts with CYBB; CYBC1 may act as a chaperone stabilizing Cytochrome b-245 heterodimer. Endoplasmic reticulum membrane ; Single-pass membrane protein Mutants are highly susceptible to Salmonella and Listeria infection and are impaired in their ability to control replication of either pathogen (PubMed:28351984). Mutant neutrophiles have a highly impaired superoxide burst (PubMed:28351984). Mice are very susceptible to Listeria monocytogenes and die within 5 days of infection, fail to form neutrophil extracellular traps but are resistant to melanoma metastasis (PubMed:28351984). Belongs to the CYBC1 family. immune system process molecular_function endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane innate immune response respiratory burst after phagocytosis uc007mvn.1 uc007mvn.2 uc007mvn.3 uc007mvn.4 
ENSMUST00000038720.8 Odad1 ENSMUST00000038720.8 Component of the outer dynein arm-docking complex that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). (from UniProt Q3UX62) AK135860 Ccdc114 ENSMUST00000038720.1 ENSMUST00000038720.2 ENSMUST00000038720.3 ENSMUST00000038720.4 ENSMUST00000038720.5 ENSMUST00000038720.6 ENSMUST00000038720.7 ODAD1_MOUSE Q3UX62 Q91WT0 uc009gxz.1 uc009gxz.2 uc009gxz.3 uc009gxz.4 Component of the outer dynein arm-docking complex that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). Component of the outer dynein arm-docking complex along with ODAD2, ODAD3, ODAD4 and CLXN. Interacts with ODAD3. Interacts with ODAD4; this interaction may facilitate the recruitment and/or attachment of outer dynein arm docking complex proteins including ODAD1, ODAD3, and ODAD4 to ciliary axonemes. Interacts with DNAH9. Interacts with MNS1 (By similarity). Interacts with PIERCE1 and PIERCE2; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme (By similarity). Cytoplasm, cytoskeleton, cilium axoneme Expressed in motile ciliated tissues. Belongs to the ODA1/DCC2 family. cilium movement molecular_function cilium axoneme outer dynein arm outer dynein arm assembly cell projection uc009gxz.1 uc009gxz.2 uc009gxz.3 uc009gxz.4 
ENSMUST00000038730.7 Rtp1 ENSMUST00000038730.7 receptor transporter protein 1 (from RefSeq NM_001004151.2) ENSMUST00000038730.1 ENSMUST00000038730.2 ENSMUST00000038730.3 ENSMUST00000038730.4 ENSMUST00000038730.5 ENSMUST00000038730.6 Gm604 NM_001004151 Q8C8C1 RTP1_MOUSE uc007ytq.1 uc007ytq.2 Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs. Interacts with olfactory receptors. Cell membrane ; Single-pass type III membrane protein Note=Effective cell surface expression depends upon interaction with olfactory receptors. Predominantly expressed in olfactory and vomeronasal organs, in mature olfactory sensory neurons. Belongs to the TMEM7 family. detection of chemical stimulus involved in sensory perception of bitter taste plasma membrane protein targeting to membrane cell surface membrane integral component of membrane olfactory receptor binding protein insertion into membrane uc007ytq.1 uc007ytq.2 
ENSMUST00000038738.7 Cdkn2aip ENSMUST00000038738.7 CDKN2A interacting protein, transcript variant 2 (from RefSeq NM_001359133.1) A0A1I7Q4A1 A0A1I7Q4A1_MOUSE Cdkn2aip ENSMUST00000038738.1 ENSMUST00000038738.2 ENSMUST00000038738.3 ENSMUST00000038738.4 ENSMUST00000038738.5 ENSMUST00000038738.6 NM_001359133 uc009lri.1 uc009lri.2 uc009lri.3 uc009lri.4 Nucleus, nucleoplasm Belongs to the CARF family. uc009lri.1 uc009lri.2 uc009lri.3 uc009lri.4 
ENSMUST00000038739.5 Rfwd3 ENSMUST00000038739.5 ring finger and WD repeat domain 3 (from RefSeq NM_146218.4) ENSMUST00000038739.1 ENSMUST00000038739.2 ENSMUST00000038739.3 ENSMUST00000038739.4 NM_146218 Q3UV90 Q6PJA8 Q8CIK8 Q8R2T9 Q8R351 RFWD3_MOUSE Rnf201 uc009nmb.1 uc009nmb.2 E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination. Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with MDM2 and p53/TP53. Binds to the RPA complex via direct interaction with RPA2. Interacts with RAD51. Nucleus Nucleus, PML body Cytoplasm Note=In undamaged cells, found both in the cytoplasm and in the nucleus, partially associated with PML nuclear bodies. In response to replication block, such as that caused by hydroxyurea treatment, or to DNA damage caused by ionizing radiations or doxorubicin, recruited to the nucleus, to stalled replication forks or to sites of DNA repair. This recruitment depends upon RPA2. The coiled coil domain may be involved in RPA2-binding. Phosphorylated at Ser-59 and Ser-75 upon DNA damage by ATM or ATR. ATM phosphorylation occurs at early times upon DNA damage, while ATR is the major kinase at later times. Phosphorylation by ATM and ATR is required to stabilize p53/TP53. Part of the phosphorylation depends upon RPA2 presence. Mice are viable and do not show overt phenotypic abnormalities, although there is some evidence for increased embryonic lethality, earlier death, and subfertility, associated with testicular and ovarian atrophy in mutant. Mutant mice embryonic fibroblasts are hypersensitive to DNA cross-linking agents and show increased chromosomal breakage compared to controls. Sequence=AAH27246.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; double-strand break repair via homologous recombination p53 binding ubiquitin-protein transferase activity nucleus nucleoplasm cytoplasm DNA repair cellular response to DNA damage stimulus response to ionizing radiation protein ubiquitination PML body transferase activity chromosome breakage replication fork processing mitotic G1 DNA damage checkpoint site of double-strand break interstrand cross-link repair metal ion binding MDM2/MDM4 family protein binding regulation of DNA damage checkpoint uc009nmb.1 uc009nmb.2 
ENSMUST00000038749.11 Padi6 ENSMUST00000038749.11 peptidyl arginine deiminase, type VI (from RefSeq NM_153106.2) ENSMUST00000038749.1 ENSMUST00000038749.10 ENSMUST00000038749.2 ENSMUST00000038749.3 ENSMUST00000038749.4 ENSMUST00000038749.5 ENSMUST00000038749.6 ENSMUST00000038749.7 ENSMUST00000038749.8 ENSMUST00000038749.9 NM_153106 PADI6_MOUSE Pad6 Padi5 Q75WC6 Q8K3V4 uc008vnc.1 uc008vnc.2 Catalyzes the deimination of arginine residues of proteins (By similarity). In oocytes, is released during cortical reaction and plays a role in preimplantation cleavage and early embryonic development (PubMed:16137333). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:17587491). Reaction=H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+); Xref=Rhea:RHEA:18089, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:10588, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29965, ChEBI:CHEBI:83397; EC=3.5.3.15; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Cytoplasm Nucleus Cytoplasmic vesicle, secretory vesicle, Cortical granule Note=Predominantly cytoplasmic (oocyte cytoplasmic sheets), also nuclear. Released extracellularly during the cortical reaction, and remains associated with the blastomeres surfaces as a peripheral membrane protein until the blastocyst stage of development (PubMed:16137333). Expressed at very high levels in oocytes. Weakly expressed in testis. Expressed in primordial, primary, secondary and Graafian follicles, and in immature oocytes, mature eggs and blastocyst (at protein level). Detected in developing oocytes and early embryo. Detected in immature-germinal vesicle-stage oocytes, mature metaphase II arrested eggs and pronuclear zygotes, 2-cell, 4-cell and morula stages. Expression decreases in blastocyst stage. Phosphorylation at Ser-2, possibly by RSK-type kinases, and Ser- 434 creates binding sites for 14-3-3 proteins. Knockout aninmals are viable and present at the expected Mendelian ratio. They do not exhibit any overt abnormalities. Female mice exhibit dispersal of the cytoskeletal sheets in oocytes that lead to a failure of zygotes to progress beyond the 2-cell stage and infertility (PubMed:17587491). Male fertility is not affected (PubMed:17587491). Belongs to the protein arginine deiminase family. protein-arginine deiminase activity calcium ion binding protein binding nucleus cytoplasm cytoskeleton organization cytoplasm organization hydrolase activity protein citrullination cellular protein localization histone citrullination regulation of translation by machinery localization intermediate filament cytoskeleton uc008vnc.1 uc008vnc.2 
ENSMUST00000038750.7 Tas2r108 ENSMUST00000038750.7 taste receptor, type 2, member 108 (from RefSeq NM_020502.1) ENSMUST00000038750.1 ENSMUST00000038750.2 ENSMUST00000038750.3 ENSMUST00000038750.4 ENSMUST00000038750.5 ENSMUST00000038750.6 NM_020502 Q53Z44 Q9JKT3 TA2R4_MOUSE Tas2r4 Tas2r8 uc009bmw.1 uc009bmw.2 uc009bmw.3 Gustducin-coupled receptor for denatonium and N(6)-propyl-2- thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity). Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia. Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity plasma membrane cilium signal transduction G-protein coupled receptor signaling pathway respiratory gaseous exchange taste receptor activity membrane integral component of membrane bitter taste receptor activity cell projection response to stimulus sensory perception of taste ciliary membrane uc009bmw.1 uc009bmw.2 uc009bmw.3 
ENSMUST00000038753.6 Sh3pxd2b ENSMUST00000038753.6 SH3 and PX domains 2B (from RefSeq NM_177364.4) A2AAY5 B6F0V1 ENSMUST00000038753.1 ENSMUST00000038753.2 ENSMUST00000038753.3 ENSMUST00000038753.4 ENSMUST00000038753.5 Fad49 NM_177364 Q1LZL8 Q1LZM5 Q3TB89 Q8BIC6 SPD2B_MOUSE Tks4 uc007ijq.1 uc007ijq.2 uc007ijq.3 Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation. Interacts with NOXO1 (By similarity). Interacts (via SH3 domains) with NOXA1; the interaction is direct (By similarity). Interacts with ADAM15. Interacts with FASLG (By similarity). Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC- transformed cells. Highly expressed in the stromal-vascular fraction of white adipose tissue with moderate expression in heart, skeletal muscle and the mature adipocyte fraction of white adipose tissue. Also expressed in brain, spleen, kidney and liver. Expressed in white and brown adipose tissues, eye, lung, heart, brain, spleen, stomach, liver and skeletal muscle (at protein level). Not expressed in kidney or bone marrow. Expression increases quickly after induction of adipocyte differentiation, reaches a maximum after 3 hours and decreases by 12 hours. Expressed from embryonic day 10.5 dpc in heart and hindbrain, followed by an increased expression at 12.5 dpc that also involves a subset of cells on the luminal side of the left ventricular wall in the case of the heart and neuroepithelium in the case of the brain. At 14.5 dpc, expression is present in developing bones (proximal ribs, lower jaw and clavicle), but the expression in the heart is no longer detectable. At stages 16.5 dpc and 18.5 dpc, strong expression is seen in the long bones of the limbs, particularly in the growth plates, as well as in the facial and cranial bones and the primordial incisor. Expression in the ribs is seen in the proximal regions in those areas where the transition from cartilage to bone is expected to occur. Expression in the eye at 16.5 dpc is highly specific for the ganglion cell layer. The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain (By similarity). Phosphorylated in SRC-transformed cells. Exhibit skeletal, cardiac and eye phenotypes. Mice have glaucoma and suffer growth retardation as well as craniofacial defects. Skeletons show marked kyphosis, poorly aligned teeth, anomalies in the iliac crest, and a prominent xiphisternum. Mice show loss of adipose tissue as well as cardiac deficiencies, such as dysmorphic ventricular chambers, thin mitral valves and immature and disarrayed trabeculae with frequent apical indentation. Mice show loss of ROS formation. Belongs to the SH3PXD2 family. Sequence=BAC40843.1; Type=Frameshift; Evidence=; skeletal system development eye development osteoblast fate commitment podosome cytoplasm superoxide metabolic process heart development phosphatidylinositol-5-phosphate binding positive regulation of gene expression superoxide-generating NADPH oxidase activator activity extracellular matrix disassembly cell junction cell differentiation phosphatidylinositol-3-phosphate binding phosphatidylinositol binding positive regulation of multicellular organism growth SH2 domain binding cell projection positive regulation of catalytic activity positive regulation of fat cell differentiation skeletal system morphogenesis positive regulation of stress fiber assembly bone development regulation of brood size adipose tissue development phosphatidylinositol-4-phosphate binding podosome assembly protein localization to membrane phosphatidylinositol-3,5-bisphosphate binding positive regulation of adipose tissue development cranial skeletal system development uc007ijq.1 uc007ijq.2 uc007ijq.3 
ENSMUST00000038757.8 Csdc2 ENSMUST00000038757.8 cold shock domain containing C2, RNA binding (from RefSeq NM_145473.3) CSDC2_MOUSE ENSMUST00000038757.1 ENSMUST00000038757.2 ENSMUST00000038757.3 ENSMUST00000038757.4 ENSMUST00000038757.5 ENSMUST00000038757.6 ENSMUST00000038757.7 NM_145473 Pippin Q3V1F0 Q91YQ3 uc007wxs.1 uc007wxs.2 uc007wxs.3 RNA-binding factor which binds specifically to the very 3'- UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). Nucleus Cytoplasm Note=PIPPin-RNA complexes are located to the nucleus. nucleic acid binding RNA binding mRNA 3'-UTR binding nucleus cytoplasm mRNA processing transcription factor binding regulation of mRNA stability uc007wxs.1 uc007wxs.2 uc007wxs.3 
ENSMUST00000038760.10 Lad1 ENSMUST00000038760.10 ladinin (from RefSeq NM_133664.3) ENSMUST00000038760.1 ENSMUST00000038760.2 ENSMUST00000038760.3 ENSMUST00000038760.4 ENSMUST00000038760.5 ENSMUST00000038760.6 ENSMUST00000038760.7 ENSMUST00000038760.8 ENSMUST00000038760.9 LAD1_MOUSE NM_133664 P57016 uc007ctt.1 uc007ctt.2 uc007ctt.3 Anchoring filament protein which is a component of the basement membrane zone. Secreted, extracellular space, extracellular matrix, basement membrane Expressed in kidney, lung and keratinocytes followed by liver, spleen and brain. Not expressed in testis, skeletal and heart muscle and in fibroblasts. structural molecule activity extracellular region basement membrane actin cytoskeleton uc007ctt.1 uc007ctt.2 uc007ctt.3 
ENSMUST00000038765.6 Inhbb ENSMUST00000038765.6 inhibin beta-B (from RefSeq NM_008381.4) ENSMUST00000038765.1 ENSMUST00000038765.2 ENSMUST00000038765.3 ENSMUST00000038765.4 ENSMUST00000038765.5 INHBB_MOUSE NM_008381 Q04999 Q3V1N0 Q61277 Q80VC4 uc007cir.1 uc007cir.2 This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Homozygous knockout mice for this gene exhibit eyelid defects. [provided by RefSeq, Aug 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC048845.1, AK132352.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Homo- or heterodimer; disulfide-linked. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 (By similarity). Secreted. Uterus, testis, ovary, lung, kidney, brain, CJ7 embryonic stem cells, and possibly in liver. Belongs to the TGF-beta family. eye development cytokine activity transforming growth factor beta receptor binding hormone activity extracellular region extracellular space growth factor activity cellular response to starvation response to wounding positive regulation of pathway-restricted SMAD protein phosphorylation cellular response to insulin stimulus activin receptor signaling pathway inhibin binding protein homodimerization activity regulation of apoptotic process regulation of MAPK cascade inhibin B complex cellular response to leptin stimulus fat cell differentiation negative regulation of insulin secretion positive regulation of follicle-stimulating hormone secretion negative regulation of follicle-stimulating hormone secretion protein heterodimerization activity negative regulation of hepatocyte growth factor biosynthetic process cell development perinuclear region of cytoplasm oocyte development positive regulation of ovulation SMAD protein signal transduction cellular response to cholesterol cell periphery positive regulation of apoptotic signaling pathway uc007cir.1 uc007cir.2 
ENSMUST00000038769.3 S100g ENSMUST00000038769.3 S100 calcium binding protein G (from RefSeq NM_009789.2) Calb3 ENSMUST00000038769.1 ENSMUST00000038769.2 NM_009789 Q5VM59 Q5VM59_MOUSE S100g uc009uus.1 uc009uus.2 Belongs to the S-100 family. calcium ion binding metal ion binding transition metal ion binding uc009uus.1 uc009uus.2 
ENSMUST00000038770.4 Vasn ENSMUST00000038770.4 vasorin (from RefSeq NM_139307.3) ENSMUST00000038770.1 ENSMUST00000038770.2 ENSMUST00000038770.3 NM_139307 Q8BJJ0 Q8R2G5 Q9CZT5 Slitl2 VASN_MOUSE uc007xzz.1 uc007xzz.2 uc007xzz.3 uc007xzz.4 May act as an inhibitor of TGF-beta signaling. Interacts with TGFB1, TGFB2 and TGFB3. Membrane ; Single-pass type I membrane protein Expression begins at 10.5 dpc and increases as development progresses to 17.5 dpc. Expression rises in parallel with the differentiation of vascular smooth muscle cells (VSMCs) of the aorta. Upon retinoic acid-induced differentiation of smooth muscle cells in vitro. N-glycosylated. protein binding extracellular space mitochondrion plasma membrane cell surface negative regulation of epithelial to mesenchymal transition membrane integral component of membrane negative regulation of transforming growth factor beta receptor signaling pathway extracellular matrix transforming growth factor beta binding extracellular exosome cellular response to hypoxia cellular response to redox state uc007xzz.1 uc007xzz.2 uc007xzz.3 uc007xzz.4 
ENSMUST00000038775.6 Ndn ENSMUST00000038775.6 necdin, MAGE family member (from RefSeq NM_010882.3) B9EJJ5 ENSMUST00000038775.1 ENSMUST00000038775.2 ENSMUST00000038775.3 ENSMUST00000038775.4 ENSMUST00000038775.5 NECD_MOUSE NM_010882 P25233 Q542W7 Q61951 uc009hff.1 uc009hff.2 uc009hff.3 uc009hff.4 Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences. Binds to the transactivation domains of E2F1 and p53. Binds also SV40 large T antigen and adenovirus E1A. Interacts with nucleobindin 1 and 2. P25233; Q61501: E2f1; NbExp=6; IntAct=EBI-1801080, EBI-1025536; P25233; Q9QYH6: Maged1; NbExp=7; IntAct=EBI-1801080, EBI-1801274; P25233; P13297: Msx1; NbExp=2; IntAct=EBI-1801080, EBI-903969; P25233; Q03358: Msx2; NbExp=3; IntAct=EBI-1801080, EBI-1801354; P25233; Q9Y6B2: EID1; Xeno; NbExp=5; IntAct=EBI-1801080, EBI-1049975; P25233; P08138: NGFR; Xeno; NbExp=3; IntAct=EBI-1801080, EBI-1387782; Cytoplasm Nucleus, nucleoplasm Nucleus matrix Note=Mainly cytoplasmic. Translocates to the nucleus where it is found associated with the nuclear matrix. Brain specific. Not detected in other tissues. Expressed in postmitotic neurons. In adult brain the highest expression is in hypothalamus. Highly expressed in thalamus and midbrain. Relatively low levels are in cerebral cortex, hippocampus, striatum, olfactory bulb, cerebellum, pons and spinal cord. Also detected in neurally differentiated embryonal carcinoma cells. Expression levels were high during embryonic and neonatal periods (14 dpc to P7) and decreased thereafter. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding neuron migration respiratory system process DNA binding protein binding nucleus nucleoplasm cytoplasm centrosome cytosol regulation of transcription, DNA-templated axonogenesis axonal fasciculation central nervous system development respiratory gaseous exchange negative regulation of cell proliferation glial cell migration post-embryonic development nuclear matrix sensory perception of pain regulation of growth cell projection gamma-tubulin binding positive regulation of transcription from RNA polymerase II promoter neurotrophin TRK receptor signaling pathway neuron development axon extension multicellular organismal homeostasis genetic imprinting uc009hff.1 uc009hff.2 uc009hff.3 uc009hff.4 
ENSMUST00000038782.4 Mael ENSMUST00000038782.4 maelstrom spermatogenic transposon silencer (from RefSeq NM_175296.4) ENSMUST00000038782.1 ENSMUST00000038782.2 ENSMUST00000038782.3 MAEL_MOUSE Mael NM_175296 Q8BVN9 uc007dkk.1 uc007dkk.2 Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage. Interacts with SMARCB1, SIN3B and DDX4. Interacts with piRNA- associated proteins TDRD1, PIWIL1 and PIWIL2. Interacts with Tex19.1 and, probably, Tex19.2 (PubMed:28254886). Cytoplasm cleus te=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Recruited to perinuclear nuage during spermatogenesis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies. PubMed:16787967, reported an association with the nuclear XY body, however, PubMed:18694567 showed that it is not the case because the antibody used by PubMed:16787967 still stains the nuclear XY body in spermatocytes lacking Mael. Moreover other antibodies raized against the same epitope used in PubMed:16787967 do not recognize any epitopes on XY chromosomes but show a clear localization to the meiotic nuage. Testis-specific. Present in spermatocytes and round and early elongating spermatids. Present from 12.5 dpc, although at this stage, protein levels are low. In the male, from 12.5 until 14.5 cpc, it localizes to the cytoplasm of germ cells, but from 15.5-16.5 dpc, it localizes to the nucleus as well. In the female, it is cytoplasmic in germ cells throughout embryonic gonad development (at protein level). In testis, low levels are observed in the early stages of meiotic prophase I (leptonema to midpachynema). Starts to accumulate throughout the cytoplasm and in prominent perinuclear nuage in late pachytene and diplotene spermatocytes. Meiotic metaphases and secondary spermatocytes show a high level in the cytoplasm as well as in nuage. Present in the chromatoid body and in a second smaller nuage in round spermatids (at protein level). Mice are viable but show profound defect in synapsis of homologous chromosomes in male meiosis, piRNA production defects, DNA demethylation of LINE-1 (L1) transposable elements and a 100-fold increase in L1 expression in the adult testis. In the adult testes, L1 transposon derepression occurs at the onset of meiosis. As a result, spermatocytes are flooded with L1 ribonucleoproteins (RNPs) that accumulates in large cytoplasmic enclaves and nuclei. Spermatocytes with nuclear L1 RNPs exhibit massive DNA damage and severe chromosome asynapsis. In gonocytes, PIWIL4, TDRD9, and DDX4 are lost from piP-bodies, whereas no effects on pi-body composition are observed. Belongs to the maelstrom family. negative regulation of transcription from RNA polymerase II promoter chromatin cell morphogenesis XY body DNA binding RNA binding protein binding nucleus nucleoplasm cytoplasm cytosol cellular response to DNA damage stimulus synapsis male meiosis multicellular organism development spermatogenesis intrinsic apoptotic signaling pathway in response to DNA damage fertilization negative regulation of gene expression cell differentiation autosome gene silencing by RNA chromatoid body piRNA metabolic process DNA methylation involved in gamete generation negative regulation of apoptotic process P granule sequence-specific DNA binding negative regulation of transcription, DNA-templated regulation of organ growth perinuclear region of cytoplasm meiotic cell cycle regulation of gene silencing by miRNA piP-body uc007dkk.1 uc007dkk.2 
ENSMUST00000038791.15 Gde1 ENSMUST00000038791.15 glycerophosphodiester phosphodiesterase 1 (from RefSeq NM_019580.4) ENSMUST00000038791.1 ENSMUST00000038791.10 ENSMUST00000038791.11 ENSMUST00000038791.12 ENSMUST00000038791.13 ENSMUST00000038791.14 ENSMUST00000038791.2 ENSMUST00000038791.3 ENSMUST00000038791.4 ENSMUST00000038791.5 ENSMUST00000038791.6 ENSMUST00000038791.7 ENSMUST00000038791.8 ENSMUST00000038791.9 GDE1_MOUSE Gde1 Mir16 NM_019580 Q3UBU4 Q9JL56 uc009jki.1 uc009jki.2 uc009jki.3 Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (PubMed:18227059, PubMed:21801852, PubMed:25596343). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti- inflammatory), and N-oleoylethanolamine (an anorexic) (PubMed:18227059). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N- acylethanolamine (PubMed:21801852, PubMed:25596343). However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (PubMed:21801852, PubMed:25596343). Has little or no activity towards glycerophosphocholine (By similarity). Reaction=H2O + sn-glycero-3-phospho-1D-myo-inositol = H(+) + myo- inositol + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:16501, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268, ChEBI:CHEBI:57597, ChEBI:CHEBI:58444; EC=3.1.4.44; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16502; Evidence=; Reaction=1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z- eicosatetraenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn- glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)- ethanolamine; Xref=Rhea:RHEA:53192, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:137016, ChEBI:CHEBI:137017; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53193; Evidence=; Reaction=1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)- ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine; Xref=Rhea:RHEA:53188, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71466, ChEBI:CHEBI:137010, ChEBI:CHEBI:137017; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53189; Evidence=; Reaction=1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl- ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine; Xref=Rhea:RHEA:53184, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71464, ChEBI:CHEBI:137009, ChEBI:CHEBI:137017; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53185; Evidence=; Reaction=H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3- phosphoethanolamine = H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)- docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:45444, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597, ChEBI:CHEBI:85250, ChEBI:CHEBI:85252; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45445; Evidence=; Reaction=H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:45440, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597, ChEBI:CHEBI:85228, ChEBI:CHEBI:85253; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45441; Evidence=; Reaction=H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:45436, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597, ChEBI:CHEBI:71464, ChEBI:CHEBI:85226; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45437; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:45432, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597, ChEBI:CHEBI:71466, ChEBI:CHEBI:85229; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45433; Evidence=; Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3- phosphoethanolamine = H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)- ethanolamine + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:45428, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597, ChEBI:CHEBI:85230; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45429; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by EDTA, calcium chloride, and zinc chloride (PubMed:18227059, PubMed:25596343). Enhanced by magnesium chloride (PubMed:18227059, PubMed:25596343). Glycerophosphodiester phosphodiesterase activity can be modulated by G-protein signaling pathways (By similarity). pH dependence: Optimum pH is 7.4. Interacts with PRAF2 (By similarity). Interacts with RGS16 (By similarity). Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Note=Perinuclear vesicles and cell membrane. Widely expressed (PubMed:10760272). Highly expressed in the brain and spinal cord, followed by kidney, liver, and testis. In contrast, little or no expression is detected in the heart or spleen (PubMed:18227059). N-glycosylated. Belongs to the glycerophosphoryl diester phosphodiesterase family. lysophospholipase activity plasma membrane integral component of plasma membrane lipid metabolic process phospholipid metabolic process G-protein coupled receptor signaling pathway phosphoric diester hydrolase activity glycerophosphodiester phosphodiesterase activity membrane integral component of membrane hydrolase activity cytoplasmic vesicle membrane cytoplasmic vesicle metal ion binding glycerophosphoinositol glycerophosphodiesterase activity N-acylethanolamine metabolic process uc009jki.1 uc009jki.2 uc009jki.3 
ENSMUST00000038794.6 Dpp9 ENSMUST00000038794.6 dipeptidylpeptidase 9, transcript variant 2 (from RefSeq NM_172624.3) DPP9_MOUSE Dpp9 ENSMUST00000038794.1 ENSMUST00000038794.2 ENSMUST00000038794.3 ENSMUST00000038794.4 ENSMUST00000038794.5 NM_172624 Q6KAM9 Q8BVG4 Q8BWT9 uc008dbh.1 uc008dbh.2 uc008dbh.3 uc008dbh.4 Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:24223149). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29396289). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (By similarity). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity). Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.; EC=3.4.14.5; Evidence=; Inhibited by the serine proteinase inhibitor 4-(2- aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di- isopropylfluorophosphate (By similarity). Inhibited by Val-boroPro (Talabostat, PT-100), a non-selective inhibitor, which triggers pyroptosis in monocytes and macrophages (PubMed:27820798, PubMed:29396289). Val-boroPro inhibits activity by binding to the active site, mimicking a substrate-bound state, thereby displacing the C-terminal fragment of NLRP1, leading to activation of the NLRP1 inflammasome. In contrast, Val-boroPro does not directly displaces CARD8: it acts by promoting degradation of the N-terminal part of CARD8, leading to indirect disruption of the ternary complex (By similarity). Homodimer. Forms a ternary complex with NLRP1, composed of a DPP9 homodimer, one full-length NLRP1 protein, and one cleaved C- terminus of NLRP1 (NACHT, LRR and PYD domains-containing protein 1, C- terminus). Forms a ternary complex with CARD8, composed of a DPP9 homodimer, one full-length NLRP1 protein, and one cleaved C-terminus of CARD8 (Caspase recruitment domain-containing protein 8, C-terminus). In the ternary complex, only one subunit of the DPP9 homodimer is bound to NLRP1 or CARD8. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BVG4-1; Sequence=Displayed; Name=2; IsoId=Q8BVG4-2; Sequence=VSP_013870, VSP_013871, VSP_013872; Detected in kidney, skin, brain, thymus and liver (at protein level). Detected in hypoglossal cord and first branchial arch at 10.75 dpc (at protein level). Belongs to the peptidase S9B family. DPPIV subfamily. Sequence=BAD21428.1; Type=Frameshift; Evidence=; aminopeptidase activity cytoplasm cytosol proteolysis peptidase activity serine-type peptidase activity hydrolase activity identical protein binding uc008dbh.1 uc008dbh.2 uc008dbh.3 uc008dbh.4 
ENSMUST00000038815.14 Sox5 ENSMUST00000038815.14 SRY (sex determining region Y)-box 5, transcript variant 1 (from RefSeq NM_011444.3) B2KFM9 B2KFM9_MOUSE ENSMUST00000038815.1 ENSMUST00000038815.10 ENSMUST00000038815.11 ENSMUST00000038815.12 ENSMUST00000038815.13 ENSMUST00000038815.2 ENSMUST00000038815.3 ENSMUST00000038815.4 ENSMUST00000038815.5 ENSMUST00000038815.6 ENSMUST00000038815.7 ENSMUST00000038815.8 ENSMUST00000038815.9 NM_011444 Sox5 uc009eqk.1 uc009eqk.2 uc009eqk.3 uc009eqk.4 uc009eqk.5 Nucleus DNA binding nucleus regulation of transcription, DNA-templated positive regulation of chondrocyte differentiation asymmetric neuroblast division positive regulation of cartilage development cellular response to transforming growth factor beta stimulus positive regulation of mesenchymal stem cell differentiation uc009eqk.1 uc009eqk.2 uc009eqk.3 uc009eqk.4 uc009eqk.5 
ENSMUST00000038816.13 Cxcl10 ENSMUST00000038816.13 C-X-C motif chemokine ligand 10 (from RefSeq NM_021274.2) Cxcl10 ENSMUST00000038816.1 ENSMUST00000038816.10 ENSMUST00000038816.11 ENSMUST00000038816.12 ENSMUST00000038816.2 ENSMUST00000038816.3 ENSMUST00000038816.4 ENSMUST00000038816.5 ENSMUST00000038816.6 ENSMUST00000038816.7 ENSMUST00000038816.8 ENSMUST00000038816.9 NM_021274 Q548V9 Q548V9_MOUSE Scyb10 uc008ycz.1 uc008ycz.2 uc008ycz.3 uc008ycz.4 uc008ycz.5 Secreted Belongs to the intercrine alpha (chemokine CxC) family. cytokine activity extracellular region extracellular space cell chemotaxis defense response immune response G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway chemokine activity heparin binding T cell chemotaxis regulation of T cell chemotaxis negative regulation of angiogenesis chemoattractant activity endothelial cell activation regulation of cell proliferation regulation of apoptotic process CXCR3 chemokine receptor binding positive chemotaxis positive regulation of release of sequestered calcium ion into cytosol chemokine-mediated signaling pathway cellular response to lipopolysaccharide positive regulation of monocyte chemotaxis regulation of endothelial tube morphogenesis positive regulation of T cell migration uc008ycz.1 uc008ycz.2 uc008ycz.3 uc008ycz.4 uc008ycz.5 
ENSMUST00000038824.6 Cyp24a1 ENSMUST00000038824.6 cytochrome P450, family 24, subfamily a, polypeptide 1 (from RefSeq NM_009996.4) CP24A_MOUSE Cyp-24 Cyp24 Cyp24a1 ENSMUST00000038824.1 ENSMUST00000038824.2 ENSMUST00000038824.3 ENSMUST00000038824.4 ENSMUST00000038824.5 NM_009996 Q64441 uc008ocb.1 uc008ocb.2 uc008ocb.3 uc008ocb.4 The protein encoded by this gene localizes to the mitochondrion, where it degrades calcitriol to calcitetrol. This gene is upregulated by binding of calcitriol to the upstream regulatory region and to a downstream enhancer region, thereby allowing calcitriol to autoregulate its concentration in the cell. The encoded protein may also play a role in calcium homeostasis. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK159109.1, AK159852.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24-oxidation pathway, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25- dihydroxyvitamin D(3)). With initial hydroxylation at C-24 (via C24- oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid. Hydroxylates at C-24 or C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S- hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin. Reaction=calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitetrol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:24964, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17823, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:47799; EC=1.14.15.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24965; Evidence=; Reaction=calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)- 1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:24972, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:47799, ChEBI:CHEBI:47812; EC=1.14.15.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24973; Evidence=; Reaction=(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:24976, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:47812, ChEBI:CHEBI:47813; EC=1.14.15.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24977; Evidence=; Reaction=(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1-hydroxy-23-oxo-24,25,26,27- tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:24984, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:47818, ChEBI:CHEBI:47820; EC=1.14.15.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24985; Evidence=; Reaction=(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] = calcitroate + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:24988, Rhea:RHEA-COMP:9998, Rhea:RHEA- COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:47820, ChEBI:CHEBI:58715; EC=1.14.15.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24989; Evidence=; Reaction=calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = H2O + 2 oxidized [adrenodoxin] + secalciferol; Xref=Rhea:RHEA:24968, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17933, ChEBI:CHEBI:28818, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; EC=1.14.15.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24969; Evidence=; Reaction=2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = 25- hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:49196, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:28818, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:47805; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49197; Evidence=; Reaction=25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:49268, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:47805, ChEBI:CHEBI:90980; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49269; Evidence=; Reaction=20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:49396, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:91306, ChEBI:CHEBI:91308; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49397; Evidence=; Reaction=20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:49392, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:91306, ChEBI:CHEBI:91307; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49393; Evidence=; Reaction=20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:49212, Rhea:RHEA-COMP:9998, Rhea:RHEA- COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:90983, ChEBI:CHEBI:90984; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49213; Evidence=; Reaction=20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:49208, Rhea:RHEA-COMP:9998, Rhea:RHEA- COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:90983, ChEBI:CHEBI:90986; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49209; Evidence=; Reaction=20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:49204, Rhea:RHEA-COMP:9998, Rhea:RHEA- COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:90983, ChEBI:CHEBI:90985; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49205; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Mitochondrion By 1,25-dihydroxyvitamin D(3) in kidney. Belongs to the cytochrome P450 family. osteoblast differentiation monooxygenase activity iron ion binding nucleus nucleoplasm mitochondrion plasma membrane 25-hydroxycholecalciferol-24-hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity response to vitamin D vitamin D metabolic process metal ion binding oxidation-reduction process uc008ocb.1 uc008ocb.2 uc008ocb.3 uc008ocb.4 
ENSMUST00000038829.7 Fcmr ENSMUST00000038829.7 Fc fragment of IgM receptor, transcript variant 1 (from RefSeq NM_026976.4) A0A0G2LB91 A0A0G2LB91_MOUSE ENSMUST00000038829.1 ENSMUST00000038829.2 ENSMUST00000038829.3 ENSMUST00000038829.4 ENSMUST00000038829.5 ENSMUST00000038829.6 Fcmr NM_026976 uc007cmn.1 uc007cmn.2 uc007cmn.3 membrane integral component of membrane uc007cmn.1 uc007cmn.2 uc007cmn.3 
ENSMUST00000038830.10 1110059E24Rik ENSMUST00000038830.10 RIKEN cDNA 1110059E24 gene (from RefSeq NM_025423.2) CI085_MOUSE ENSMUST00000038830.1 ENSMUST00000038830.2 ENSMUST00000038830.3 ENSMUST00000038830.4 ENSMUST00000038830.5 ENSMUST00000038830.6 ENSMUST00000038830.7 ENSMUST00000038830.8 ENSMUST00000038830.9 NM_025423 Q9CQ90 uc008gyz.1 uc008gyz.2 uc008gyz.3 molecular_function cellular_component biological_process uc008gyz.1 uc008gyz.2 uc008gyz.3 
ENSMUST00000038835.5 Scgb2b2 ENSMUST00000038835.5 secretoglobin, family 2B, member 2 (from RefSeq NM_207262.2) Abpe ENSMUST00000038835.1 ENSMUST00000038835.2 ENSMUST00000038835.3 ENSMUST00000038835.4 G5E8B4 G5E8B4_MOUSE NM_207262 Scgb2b2 uc009gij.1 uc009gij.2 uc009gij.3 Secreted Belongs to the secretoglobin family. extracellular space uc009gij.1 uc009gij.2 uc009gij.3 
ENSMUST00000038841.14 Clvs1 ENSMUST00000038841.14 clavesin 1, transcript variant 1 (from RefSeq NM_028940.2) CLVS1_MOUSE ENSMUST00000038841.1 ENSMUST00000038841.10 ENSMUST00000038841.11 ENSMUST00000038841.12 ENSMUST00000038841.13 ENSMUST00000038841.2 ENSMUST00000038841.3 ENSMUST00000038841.4 ENSMUST00000038841.5 ENSMUST00000038841.6 ENSMUST00000038841.7 ENSMUST00000038841.8 ENSMUST00000038841.9 NM_028940 Q3UWV3 Q497H3 Q8BJE8 Q8BXX0 Q9D4C9 Rlbp1l1 uc008rye.1 uc008rye.2 uc008rye.3 Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Forms a complex with clathrin heavy chain and gamma-adaptin. Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Early endosome membrane ; Peripheral membrane protein Cytoplasmic vesicle, clathrin-coated vesicle Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D4C9-1; Sequence=Displayed; Name=2; IsoId=Q9D4C9-2; Sequence=VSP_027331; Name=3; IsoId=Q9D4C9-3; Sequence=VSP_027330; The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2. Binding to PtdIns(3,5)P2 is not required for localization. Sequence=BAE22811.1; Type=Erroneous initiation; Evidence=; endosome Golgi apparatus trans-Golgi network lysosome organization lipid binding membrane clathrin-coated vesicle cytoplasmic vesicle early endosome membrane phosphatidylinositol-3,5-bisphosphate binding uc008rye.1 uc008rye.2 uc008rye.3 
ENSMUST00000038844.7 Ubd ENSMUST00000038844.7 ubiquitin D (from RefSeq NM_023137.3) ENSMUST00000038844.1 ENSMUST00000038844.2 ENSMUST00000038844.3 ENSMUST00000038844.4 ENSMUST00000038844.5 ENSMUST00000038844.6 Fat10 NM_023137 P63072 Q4FJZ5 Q9WV10 UBD_MOUSE uc008cmi.1 uc008cmi.2 uc008cmi.3 uc008cmi.4 Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated- I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen- presenting cells that initiate T-cell responses. Mediates mitotic non- disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase- dependent manner, especially in renal epithelium and tubular cells during renal diseases. Interacts directly with the 26S proteasome. The interaction with NUB1 via the N-terminal ubiquitin domain facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates its own degradation and that of its conjugates. Interacts (via ubiquitin-like 1 domain) with the spindle checkpoint protein MAD2L1 during mitosis. Present in aggresomes of proteasome inhibited cells. Interacts with HDAC6 under proteasome impairment conditions (By similarity). Forms a thioester with UBA6 in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg) (PubMed:17889673). Interacts with SQSTM1 and TP53/p53 (By similarity). Nucleus Cytoplasm Note=Accumulates in aggresomes under proteasome inhibition conditions. Mostly expressed in thymus and intestine. Rapidly degraded by the proteasome. Cell-cycle regulation with highest expression during the S-phase (at protein level). Over expressed in hepatocytes by drug injury (e.g. DDC; diethyl 1,4-dihydro- 2,4,6-trimethyl-3,5-pyridinedicarboxylate). Inducible by the pro- inflammatory cytokines tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg). Can be acetylated. Spontaneous sporadic apoptotic death. Higher sensitivity toward endotoxin challenge. Abrogated TNF-alpha-induced NF- kappa-B activation and reduced induction of NF-kappa-B-regulated genes. Impaired TNF-alpha-induced I-kappa-B-alpha degradation and nuclear translocation of p65 in RTECs. Reduced expression of LMP2. fibrillar center protein binding nucleus cytoplasm ubiquitin-dependent protein catabolic process aggresome protein ubiquitination protein modification by small protein conjugation response to interferon-gamma response to tumor necrosis factor myeloid dendritic cell differentiation positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome binding aggresome assembly regulation of mitotic cell cycle phase transition uc008cmi.1 uc008cmi.2 uc008cmi.3 uc008cmi.4 
ENSMUST00000038845.10 Cd53 ENSMUST00000038845.10 CD53 antigen (from RefSeq NM_007651.3) CD53_MOUSE ENSMUST00000038845.1 ENSMUST00000038845.2 ENSMUST00000038845.3 ENSMUST00000038845.4 ENSMUST00000038845.5 ENSMUST00000038845.6 ENSMUST00000038845.7 ENSMUST00000038845.8 ENSMUST00000038845.9 NM_007651 Q61451 Q61721 uc008qwm.1 uc008qwm.2 uc008qwm.3 uc008qwm.4 Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells. Interacts with SCIMP. Cell membrane Cell junction Membrane ; Multi-pass membrane protein Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes. Belongs to the tetraspanin (TM4SF) family. immunological synapse plasma membrane integral component of plasma membrane cell-cell junction cell surface membrane integral component of membrane cell junction positive regulation of myoblast fusion regulation of myoblast differentiation cell-cell adhesion uc008qwm.1 uc008qwm.2 uc008qwm.3 uc008qwm.4 
ENSMUST00000038856.14 Trhr ENSMUST00000038856.14 thyrotropin releasing hormone receptor (from RefSeq NM_013696.2) ENSMUST00000038856.1 ENSMUST00000038856.10 ENSMUST00000038856.11 ENSMUST00000038856.12 ENSMUST00000038856.13 ENSMUST00000038856.2 ENSMUST00000038856.3 ENSMUST00000038856.4 ENSMUST00000038856.5 ENSMUST00000038856.6 ENSMUST00000038856.7 ENSMUST00000038856.8 ENSMUST00000038856.9 NM_013696 Q32MS1 Q32MS1_MOUSE Trhr uc007vpo.1 uc007vpo.2 uc007vpo.3 Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity thyrotropin-releasing hormone receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc007vpo.1 uc007vpo.2 uc007vpo.3 
ENSMUST00000038859.14 Pik3cd ENSMUST00000038859.14 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta, transcript variant 5 (from RefSeq NM_001164050.1) ENSMUST00000038859.1 ENSMUST00000038859.10 ENSMUST00000038859.11 ENSMUST00000038859.12 ENSMUST00000038859.13 ENSMUST00000038859.2 ENSMUST00000038859.3 ENSMUST00000038859.4 ENSMUST00000038859.5 ENSMUST00000038859.6 ENSMUST00000038859.7 ENSMUST00000038859.8 ENSMUST00000038859.9 NM_001164050 Pik3cd Q8CI98 Q8CI98_MOUSE uc008vwu.1 uc008vwu.2 uc008vwu.3 uc008vwu.4 Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+); Xref=Rhea:RHEA:21292, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57836, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.153; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21293; Evidence=; Lipid metabolism. Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. nucleotide binding ATP binding phosphatidylinositol 3-kinase signaling kinase activity 1-phosphatidylinositol-3-kinase activity phosphorylation transferase activity phosphatidylinositol 3-kinase activity phosphatidylinositol-3-phosphate biosynthetic process phosphatidylinositol phosphorylation phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphatidylinositol-mediated signaling phosphatidylinositol-3,4-bisphosphate 5-kinase activity uc008vwu.1 uc008vwu.2 uc008vwu.3 uc008vwu.4 
ENSMUST00000038860.12 Spag4 ENSMUST00000038860.12 sperm associated antigen 4 (from RefSeq NM_139151.4) A3KGK4 ENSMUST00000038860.1 ENSMUST00000038860.10 ENSMUST00000038860.11 ENSMUST00000038860.2 ENSMUST00000038860.3 ENSMUST00000038860.4 ENSMUST00000038860.5 ENSMUST00000038860.6 ENSMUST00000038860.7 ENSMUST00000038860.8 ENSMUST00000038860.9 MNCb-0953 NM_139151 Q9JJF2 SPAG4_MOUSE Sun4 uc008nmd.1 uc008nmd.2 uc008nmd.3 Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail. Self-associates. Interacts with ODF1. May associate with microtubules (By similarity). Interacts with SUN3 and SYNE1; suggesting the formation of a spermatogenesis-specific LINC complex; a SUN domain- based heterotrimer of SPAG4 and SUN3 may associate with SYNE1 (PubMed:26621829). Interacts with SEPT12 and LMNB1; during spermatogenesis (By similarity). Membrane ; Multi-pass membrane protein Cytoplasm, cytoskeleton [Isoform 1]: Membrane ; Multi-pass membrane protein Cytoplasm, cytoskeleton Nucleus envelope Nucleus inner membrane Cytoplasm, cytoskeleton, flagellum axoneme Note=In spermatids, isoform 1 is localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm (By similarity). Conflictingly is not found in axoneme but only associated with the manchette where cytoplasmic microtubules contact the nuclear envelope. Localizes at the posterior lateral side of round and elongating spermatids (PubMed:26621829). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JJF2-1; Sequence=Displayed; Name=2; IsoId=Q9JJF2-2; Sequence=VSP_005958, VSP_005959; Isoform 1 is testis specific and is exclusively expressed in spermatids. Weakly expressed at day 18 p.p. and increased expression at day 21-25 p.p. with increasing spermatid numbers. Male infertility with severe defects in sperm head formation and globozoospermia-like phenotype. Although transmembrane domains are strongly predicted, they may rather represent hydrophobic globular domains associated with microtubules. nucleus nuclear envelope nuclear inner membrane cytoplasm cytoskeleton microtubule cilium nuclear envelope organization spermatogenesis membrane integral component of membrane cell differentiation motile cilium LINC complex identical protein binding cell projection protein anchor cytoskeletal anchoring at nuclear membrane uc008nmd.1 uc008nmd.2 uc008nmd.3 
ENSMUST00000038863.9 Lars2 ENSMUST00000038863.9 leucyl-tRNA synthetase, mitochondrial, transcript variant 1 (from RefSeq NM_153168.4) A6H6S4 ENSMUST00000038863.1 ENSMUST00000038863.2 ENSMUST00000038863.3 ENSMUST00000038863.4 ENSMUST00000038863.5 ENSMUST00000038863.6 ENSMUST00000038863.7 ENSMUST00000038863.8 NM_153168 Q8VDC0 SYLM_MOUSE uc009sgd.1 uc009sgd.2 uc009sgd.3 Reaction=ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl- tRNA(Leu); Xref=Rhea:RHEA:11688, Rhea:RHEA-COMP:9613, Rhea:RHEA- COMP:9622, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57427, ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:456215; EC=6.1.1.4; Mitochondrion matrix Belongs to the class-I aminoacyl-tRNA synthetase family. nucleotide binding aminoacyl-tRNA editing activity aminoacyl-tRNA ligase activity leucine-tRNA ligase activity ATP binding mitochondrion mitochondrial matrix translation tRNA aminoacylation for protein translation leucyl-tRNA aminoacylation ligase activity mitochondrial translation uc009sgd.1 uc009sgd.2 uc009sgd.3 
ENSMUST00000038868.14 Spata6 ENSMUST00000038868.14 spermatogenesis associated 6, transcript variant 1 (from RefSeq NM_026470.3) A2AED7 ENSMUST00000038868.1 ENSMUST00000038868.10 ENSMUST00000038868.11 ENSMUST00000038868.12 ENSMUST00000038868.13 ENSMUST00000038868.2 ENSMUST00000038868.3 ENSMUST00000038868.4 ENSMUST00000038868.5 ENSMUST00000038868.6 ENSMUST00000038868.7 ENSMUST00000038868.8 ENSMUST00000038868.9 Hash NM_026470 Q3U6K5 Q3V104 Q8BW97 Q99MU6 Q9D9J1 Q9DAI3 SPAT6_MOUSE Spata6 uc008udh.1 uc008udh.2 uc008udh.3 uc008udh.4 Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis (PubMed:12771232, PubMed:25605924). May be involved in myosin-based microfilament transport through interaction with myosin subunits (PubMed:25605924). Interacts with MYL6. Secreted Cell projection, cilium, flagellum Note=Specifically localizes to the segmented columns and the capitulum of the sperm connecting piece. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U6K5-1; Sequence=Displayed; Name=2; IsoId=Q3U6K5-2; Sequence=VSP_023278; Name=3; IsoId=Q3U6K5-3; Sequence=VSP_023279, VSP_023280; Specifically expressed in developing spermatids and mature spermatozoa (at protein level) (PubMed:25605924). Isoform 1 is weakly expressed in testis, ovary, thymus and placenta. Isoform 2 and isoform 3 are testis-specific. Expression isw higher in spermatids than in spermatocytes and spermatogonia (PubMed:12771232). Weak expression of isoform 1 is seen throughout testicular development. Isoform 2 and isoform 3 could not be detected until postnatal day 15. Expressed from postnatal day 20, and thereafter increased. Expressed in blastocysts and in embryos from 8.5 dpc-12.5 dpc. After 13.5 dpc, the level of expression decreases. Expressed at 9.5-10.5 dpc in the neural tube, in somites and limb buds. Male are sterile due to disruption of sperm connecting piece formation, leading to acephalic spermatozoa in the epididymis and ejaculates. Belongs to the SPATA6 family. Knockout experiments to inactivate Spata6 were first attempted but were unsuccessful, because chimeras did not transmit the targeted allele to their progeny, generating high-percentage of lethality for chimeric embryos (PubMed:12771232). This suggests that genes other than Spata6 may have been targeted or affected in this study (PubMed:25605924). Sequence=AAK20995.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; extracellular region cilium multicellular organism development spermatogenesis cell differentiation motile cilium myosin light chain binding cell projection motile cilium assembly sperm connecting piece uc008udh.1 uc008udh.2 uc008udh.3 uc008udh.4 
ENSMUST00000038874.12 Scai ENSMUST00000038874.12 suppressor of cancer cell invasion, transcript variant 1 (from RefSeq NM_178778.4) A2RTF5 A3KGQ2 ENSMUST00000038874.1 ENSMUST00000038874.10 ENSMUST00000038874.11 ENSMUST00000038874.2 ENSMUST00000038874.3 ENSMUST00000038874.4 ENSMUST00000038874.5 ENSMUST00000038874.6 ENSMUST00000038874.7 ENSMUST00000038874.8 ENSMUST00000038874.9 NM_178778 Q8C409 Q8C8K2 Q8C8N2 SCAI_MOUSE uc008jof.1 uc008jof.2 uc008jof.3 uc008jof.4 Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. Interacts with DIAPH1. Forms a nuclear ternary complex with MRTFA and SRF. Membrane ; Single-pass membrane protein Nucleus Cytoplasm Note=Nuclear localization is required for inhibition of MRTFA. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C8N2-1; Sequence=Displayed; Name=2; IsoId=Q8C8N2-2; Sequence=VSP_015121, VSP_015122; Expressed in most tissues tested with higher expression levels in brain, spleen and thymus. Belongs to the SCAI family. Sequence=BAC32904.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; transcription corepressor activity protein binding nucleus cytoplasm transcription, DNA-templated negative regulation of signal transduction membrane integral component of membrane negative regulation of cell migration nuclear membrane negative regulation of Rho protein signal transduction negative regulation of nucleic acid-templated transcription uc008jof.1 uc008jof.2 uc008jof.3 uc008jof.4 
ENSMUST00000038876.13 Emp3 ENSMUST00000038876.13 epithelial membrane protein 3, transcript variant 1 (from RefSeq NM_010129.2) EMP3_MOUSE ENSMUST00000038876.1 ENSMUST00000038876.10 ENSMUST00000038876.11 ENSMUST00000038876.12 ENSMUST00000038876.2 ENSMUST00000038876.3 ENSMUST00000038876.4 ENSMUST00000038876.5 ENSMUST00000038876.6 ENSMUST00000038876.7 ENSMUST00000038876.8 ENSMUST00000038876.9 NM_010129 O35912 O88333 Q3UIF8 Ymp uc009gxw.1 uc009gxw.2 uc009gxw.3 uc009gxw.4 Probably involved in cell proliferation and cell-cell interactions. Membrane; Multi-pass membrane protein. Belongs to the PMP-22/EMP/MP20 family. plasma membrane cell death membrane integral component of membrane bleb assembly uc009gxw.1 uc009gxw.2 uc009gxw.3 uc009gxw.4 
ENSMUST00000038886.3 Csf3 ENSMUST00000038886.3 colony stimulating factor 3 (granulocyte) (from RefSeq NM_009971.1) Csf3 ENSMUST00000038886.1 ENSMUST00000038886.2 NM_009971 Q0VB73 Q0VB73_MOUSE uc007lgy.1 uc007lgy.2 uc007lgy.3 Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Secreted Belongs to the IL-6 superfamily. cytokine activity extracellular region immune response signal transduction positive regulation of phosphatidylinositol 3-kinase signaling enzyme binding positive regulation of actin filament polymerization positive regulation of protein binding positive regulation of peptidyl-serine phosphorylation positive regulation of myeloid cell differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of peptidyl-tyrosine phosphorylation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of protein kinase B signaling cellular response to cytokine stimulus positive regulation of actin cytoskeleton reorganization uc007lgy.1 uc007lgy.2 uc007lgy.3 
ENSMUST00000038890.6 Dennd4a ENSMUST00000038890.6 DENN domain containing 4A (from RefSeq NM_001162917.2) Dennd4a E9Q8V6 E9Q8V6_MOUSE ENSMUST00000038890.1 ENSMUST00000038890.2 ENSMUST00000038890.3 ENSMUST00000038890.4 ENSMUST00000038890.5 NM_001162917 uc292idl.1 uc292idl.2 cellular_component Rab guanyl-nucleotide exchange factor activity uc292idl.1 uc292idl.2 
ENSMUST00000038896.8 Lcat ENSMUST00000038896.8 lecithin cholesterol acyltransferase (from RefSeq NM_008490.2) ENSMUST00000038896.1 ENSMUST00000038896.2 ENSMUST00000038896.3 ENSMUST00000038896.4 ENSMUST00000038896.5 ENSMUST00000038896.6 ENSMUST00000038896.7 LCAT_MOUSE NM_008490 P16301 Q8K139 uc009neq.1 uc009neq.2 uc009neq.3 uc009neq.4 Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:19065001). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels (PubMed:19065001). Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins (PubMed:19065001). Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:19065001). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn- glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O- alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:10393212). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl- sn-glycero-3-phosphocholine forming lyso-PAF (By similarity). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1- acyl-sn-glycero-3-phosphocholine + a sterol ester; Xref=Rhea:RHEA:21204, ChEBI:CHEBI:15889, ChEBI:CHEBI:35915, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=2.3.1.43; Evidence= Reaction=a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O- alkyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:17777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707; EC=3.1.1.47; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17778; Evidence=; Reaction=(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3- phosphocholine = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl- sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:43216, ChEBI:CHEBI:34310, ChEBI:CHEBI:72998, ChEBI:CHEBI:77369, ChEBI:CHEBI:82869; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43217; Evidence=; Reaction=(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)- hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine; Xref=Rhea:RHEA:43224, ChEBI:CHEBI:34310, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002, ChEBI:CHEBI:82875; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43225; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3- phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:53448, ChEBI:CHEBI:16113, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003, ChEBI:CHEBI:82751; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53449; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate); Xref=Rhea:RHEA:53456, ChEBI:CHEBI:16113, ChEBI:CHEBI:46898, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53457; Evidence=; Reaction=1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3- phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3- phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:53464, ChEBI:CHEBI:16113, ChEBI:CHEBI:72998, ChEBI:CHEBI:84346, ChEBI:CHEBI:86121; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53465; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3- phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3- phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:53460, ChEBI:CHEBI:16113, ChEBI:CHEBI:72998, ChEBI:CHEBI:86119, ChEBI:CHEBI:88752; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53461; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn- glycero-3-phosphocholine + cholesterol = (5Z,8Z,11Z,14Z,17Z- eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3- phosphocholine; Xref=Rhea:RHEA:53468, ChEBI:CHEBI:16113, ChEBI:CHEBI:72998, ChEBI:CHEBI:84969, ChEBI:CHEBI:86137; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53469; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3- phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate; Xref=Rhea:RHEA:53472, ChEBI:CHEBI:16113, ChEBI:CHEBI:41509, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53473; Evidence=; Reaction=1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3- phosphocholine + cholesterol = (6Z,9Z,12Z-octadecatrienoyl)- cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:53476, ChEBI:CHEBI:16113, ChEBI:CHEBI:72998, ChEBI:CHEBI:84786, ChEBI:CHEBI:88756; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53477; Evidence=; Reaction=1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3- phosphocholine + cholesterol = (11Z,14Z,17Z-eicosatrienoyl)- cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:53516, ChEBI:CHEBI:16113, ChEBI:CHEBI:72998, ChEBI:CHEBI:137411, ChEBI:CHEBI:137412; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53517; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3- phosphocholine + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)- cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:53520, ChEBI:CHEBI:16113, ChEBI:CHEBI:72998, ChEBI:CHEBI:84341, ChEBI:CHEBI:84789; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53521; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn- glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40812; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2- acetyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn- glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:53636, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707, ChEBI:CHEBI:72998, ChEBI:CHEBI:75219; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53637; Evidence=; APOA1 is the most potent activator in plasma. Also activated by APOE, APOC1 and APOA4. Secreted te=Secreted into blood plasma (PubMed:8820107). Produced in astrocytes and secreted into cerebral spinal fluid (CSF) (By similarity). Detected in blood plasma (PubMed:8820107). Produced and secreted by astrocytes (at protein level) (PubMed:19065001). Abundantly expressed in liver, brain and testis with highest levels in liver. In the brain, found in cerebellum, cerebral cortex, hippocampus and brain stem. Located to neurons and neuroglia. In the testis, expressed days 4,8, 14, and 35 of postnatal life with highest levels at day 35. In the brain, expressed in fetal stages and levels begin to rise after day 4 after birth and continue to increase through suckling and weaning reaching a peak at postnatal day 24. In the liver, expressed in fetal life from day 16-21 of gestation with a 3-fold increase in the four final days of gestation. Null mice exhibit a 7-fold increase in the cholesteryl ester fatty acid CEFA ratio of APOB lipoprotein CEs. There is also a 3.6 increase in vascular ring O(2) production and plasma phospholipid (PL)-bound-F2-isoprostane levels. This effect is paradoxically reversed in the APOE knockout background (PubMed:11809774, PubMed:11893779). Mice show a significant reduction in total cholesterol, HDL-cholesterol, apoA-I, serum paraoxonase and PAF acetylhydrolase enzyme activities and show a modest (36%) but significant increase in apoJ levels (PubMed:10393212). Belongs to the AB hydrolase superfamily. Lipase family. phosphatidylcholine-sterol O-acyltransferase activity phospholipase A2 activity extracellular region extracellular space lipid metabolic process phospholipid metabolic process phosphatidylcholine biosynthetic process steroid metabolic process cholesterol metabolic process O-acyltransferase activity transferase activity transferase activity, transferring acyl groups cholesterol transport apolipoprotein A-I binding high-density lipoprotein particle very-low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling cholesterol esterification lipoprotein metabolic process lipoprotein biosynthetic process cholesterol homeostasis reverse cholesterol transport phosphatidylcholine metabolic process response to copper ion response to glucocorticoid regulation of high-density lipoprotein particle assembly uc009neq.1 uc009neq.2 uc009neq.3 uc009neq.4 
ENSMUST00000038907.9 Wee2 ENSMUST00000038907.9 WEE1 homolog 2 (S. pombe) (from RefSeq NM_201370.2) ENSMUST00000038907.1 ENSMUST00000038907.2 ENSMUST00000038907.3 ENSMUST00000038907.4 ENSMUST00000038907.5 ENSMUST00000038907.6 ENSMUST00000038907.7 ENSMUST00000038907.8 NM_201370 Q4U4S4 Q66JT0 Q7TPV9 WEE2_MOUSE Wee1b uc009bmq.1 uc009bmq.2 uc009bmq.3 uc009bmq.4 Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Cytoplasm. Nucleus. Note=Localizes mainly in the nucleus. Exported from the nucleus to the cytoplasm before germinal vesicle breakdown (GVBD), allowing meiosis resumption. Ovary-specific. Detected only in the oocytes at all developmental stages of the follicle including primary, secondary, preantral, and antral follicles with an increase in signal during development. Readily detectable at the mature oocyte, but disappears at 2.5 dpc. Detected in germinal vesicle (GV) and metaphase II-stage oocyte (at protein level). Phosphorylated by PKA at Ser-15 in vitro, leading to activate kinase activity. Phosphorylation at Ser-15 by CaMK2, leading to increase its activity and promote metaphase II exit during egg activation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. nucleotide binding mitotic cell cycle magnesium ion binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity ATP binding nucleus nucleoplasm cytoplasm cytosol protein phosphorylation mitotic cell cycle checkpoint female meiotic division kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation female pronucleus assembly positive regulation of phosphorylation negative regulation of cyclin-dependent protein serine/threonine kinase activity metal ion binding meiotic cell cycle regulation of meiosis I regulation of fertilization negative regulation of oocyte maturation uc009bmq.1 uc009bmq.2 uc009bmq.3 uc009bmq.4 
ENSMUST00000038913.16 Cnot3 ENSMUST00000038913.16 CCR4-NOT transcription complex, subunit 3 (from RefSeq NM_146176.3) B2RUA7 CNOT3_MOUSE ENSMUST00000038913.1 ENSMUST00000038913.10 ENSMUST00000038913.11 ENSMUST00000038913.12 ENSMUST00000038913.13 ENSMUST00000038913.14 ENSMUST00000038913.15 ENSMUST00000038913.2 ENSMUST00000038913.3 ENSMUST00000038913.4 ENSMUST00000038913.5 ENSMUST00000038913.6 ENSMUST00000038913.7 ENSMUST00000038913.8 ENSMUST00000038913.9 NM_146176 Not3 Q8K0V4 uc009evl.1 uc009evl.2 uc009evl.3 uc009evl.4 Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT2. Interacts with TIP120B and NANOS2 (PubMed:20133598). Interacts with EBF1 (By similarity). Nucleus Cytoplasm, P-body Note=NANOS2 promotes its localization to P-body. Expressed in embryonic stem (ES) cells and in inner cell mass (ICM) of the blastocyst. Decreased levels in liver and white adipose tissues upon fasting,. Belongs to the CNOT2/3/5 family. P-body trophectodermal cell differentiation protein binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of translation multicellular organism development negative regulation of translation CCR4-NOT complex CCR4-NOT core complex gene silencing by RNA negative regulation of intracellular estrogen receptor signaling pathway regulation of stem cell population maintenance uc009evl.1 uc009evl.2 uc009evl.3 uc009evl.4 
ENSMUST00000038920.2 Gpr63 ENSMUST00000038920.2 G protein-coupled receptor 63, transcript variant 1 (from RefSeq NM_030733.4) ENSMUST00000038920.1 GPR63_MOUSE NM_030733 Q8BZ93 Q9EQQ3 uc008see.1 uc008see.2 Orphan receptor. May play a role in brain function. Cell membrane; Multi-pass membrane protein. Brain specific. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity nucleus cytosol plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane receptor complex uc008see.1 uc008see.2 
ENSMUST00000038928.7 H1f9 ENSMUST00000038928.7 H1.9 linker histone (from RefSeq NM_018792.2) ENSMUST00000038928.1 ENSMUST00000038928.2 ENSMUST00000038928.3 ENSMUST00000038928.4 ENSMUST00000038928.5 ENSMUST00000038928.6 H1-9 H1-9p H1f9 HILS1_MOUSE Hils1 NM_018792 Q9QYL0 uc007kzq.1 uc007kzq.2 uc007kzq.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is expressed in nuclei of late maturing spermatids. [provided by RefSeq, Nov 2015]. ##Evidence-Data-START## Transcript is intronless :: BC061119.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 22650316 ##RefSeq-Attributes-END## DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa. Nucleus romosome Expressed exclusively in the testis by haploid germ cells (at protein level). Expression initiated at step 9 of spermatid development and peaked between steps 10-13. Expression decreased abruptly at step 14 and was undetectable after step 15. Belongs to the histone H1/H5 family. nucleosome nuclear chromatin DNA binding double-stranded DNA binding nucleus chromosome nuclear euchromatin chromatin organization nucleosome assembly regulation of transcription, DNA-templated multicellular organism development spermatogenesis nucleosome positioning cell differentiation chromosome condensation nucleosomal DNA binding negative regulation of chromatin silencing negative regulation of DNA recombination uc007kzq.1 uc007kzq.2 uc007kzq.3 
ENSMUST00000038932.14 Odf4 ENSMUST00000038932.14 outer dense fiber of sperm tails 4 (from RefSeq NM_145746.2) ENSMUST00000038932.1 ENSMUST00000038932.10 ENSMUST00000038932.11 ENSMUST00000038932.12 ENSMUST00000038932.13 ENSMUST00000038932.2 ENSMUST00000038932.3 ENSMUST00000038932.4 ENSMUST00000038932.5 ENSMUST00000038932.6 ENSMUST00000038932.7 ENSMUST00000038932.8 ENSMUST00000038932.9 NM_145746 ODFP4_MOUSE Oppo1 Q6P8Z7 Q8VI88 uc007joj.1 uc007joj.2 uc007joj.3 uc007joj.4 Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VI88-1; Sequence=Displayed; Name=2; IsoId=Q8VI88-2; Sequence=VSP_028117, VSP_028118; Expressed in testis. Expressed from late pachytene stage and expression persists during embryonic development. outer dense fiber molecular_function plasma membrane multicellular organism development spermatogenesis biological_process membrane integral component of membrane cell differentiation motile cilium uc007joj.1 uc007joj.2 uc007joj.3 uc007joj.4 
ENSMUST00000038942.10 Pbxip1 ENSMUST00000038942.10 pre B cell leukemia transcription factor interacting protein 1 (from RefSeq NM_146131.2) ENSMUST00000038942.1 ENSMUST00000038942.2 ENSMUST00000038942.3 ENSMUST00000038942.4 ENSMUST00000038942.5 ENSMUST00000038942.6 ENSMUST00000038942.7 ENSMUST00000038942.8 ENSMUST00000038942.9 Hpip NM_146131 PBIP1_MOUSE Q3TD91 Q3TVI8 Q3TWL9 Q8R319 uc008pzr.1 uc008pzr.2 uc008pzr.3 uc008pzr.4 Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor- alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity). Interacts with ESR1, PBX1, PBX2 and PBX3 (By similarity). Interacts with TEX11. Cytoplasm, cytoskeleton Nucleus Note=Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus. The C-terminal domain (AA 443-731) contains a nuclear export signal. Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218). molecular_function transcription corepressor activity nucleus cytoplasm cytoskeleton microtubule membrane cell differentiation negative regulation of transcription, DNA-templated regulation of Rho guanyl-nucleotide exchange factor activity uc008pzr.1 uc008pzr.2 uc008pzr.3 uc008pzr.4 
ENSMUST00000038945.6 Phlda3 ENSMUST00000038945.6 pleckstrin homology like domain, family A, member 3 (from RefSeq NM_013750.2) ENSMUST00000038945.1 ENSMUST00000038945.2 ENSMUST00000038945.3 ENSMUST00000038945.4 ENSMUST00000038945.5 NM_013750 PHLA3_MOUSE Q9WV95 Tih1 uc007ctq.1 uc007ctq.2 uc007ctq.3 uc007ctq.4 p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor (By similarity). Cytoplasm Membrane ; Peripheral membrane protein Widely expressed in fetal tissues, with the exception of liver. Strongly expressed in adult skeletal muscle and lung. Widely expressed at lower levels in other adult tissues, with weakest expression in liver and spleen. Expressed in extraembryonic tissues and placenta at 11.5 and 18.5 dpc (at protein level). Expression continues throughout gestation and is strong in adult lung (at protein level). The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling (By similarity). Mice are viable and fertile, and show normal placenta and embryonic weights. Belongs to the PHLDA3 family. phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm plasma membrane apoptotic process phosphatidylinositol-5-phosphate binding membrane phosphatidylinositol-3-phosphate binding intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic process phosphatidylinositol-3,4-bisphosphate binding negative regulation of protein kinase B signaling phosphatidylinositol-3,5-bisphosphate binding uc007ctq.1 uc007ctq.2 uc007ctq.3 uc007ctq.4 
ENSMUST00000038946.9 Lsp1 ENSMUST00000038946.9 lymphocyte specific 1, transcript variant 2 (from RefSeq NM_019391.4) A2A6J5 A2A6J6 ENSMUST00000038946.1 ENSMUST00000038946.2 ENSMUST00000038946.3 ENSMUST00000038946.4 ENSMUST00000038946.5 ENSMUST00000038946.6 ENSMUST00000038946.7 ENSMUST00000038946.8 LSP1_MOUSE NM_019391 P19973 P97339 Pp52 Q04950 Q62022 Q62023 Q62024 Q8CD28 Q99L65 S37 Wp34 uc009knf.1 uc009knf.2 uc009knf.3 uc009knf.4 May play a role in mediating neutrophil activation and chemotaxis. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P19973-1; Sequence=Displayed; Name=2; IsoId=P19973-2; Sequence=VSP_004313; Isoform 1 is expressed in normal mouse B and T- lymphocytes and in transformed B-cells but not (or in smaller amounts) in nine T-lymphoma lines tested. Isoform 2 is expressed in non-lymphoid cell lines (myocytes, stromal cells, fibroblasts). Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis. actin binding plasma membrane apoptotic process chemotaxis defense response cytoskeleton organization signal transduction membrane cellular response to interleukin-7 uc009knf.1 uc009knf.2 uc009knf.3 uc009knf.4 
ENSMUST00000038949.6 Adrb1 ENSMUST00000038949.6 adrenergic receptor, beta 1 (from RefSeq NM_007419.3) ADRB1_MOUSE Adrb1r B2RVY4 ENSMUST00000038949.1 ENSMUST00000038949.2 ENSMUST00000038949.3 ENSMUST00000038949.4 ENSMUST00000038949.5 NM_007419 P34971 uc008hze.1 uc008hze.2 uc008hze.3 uc008hze.4 Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (PubMed:31473062). Interacts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct. Interacts with GOPC, MAGI3 and DLG4 (By similarity). P34971; P18762: Adrb2; NbExp=2; IntAct=EBI-7764182, EBI-491143; P34971; Q01063: Pde4d; NbExp=3; IntAct=EBI-7764182, EBI-7764239; Cell membrane ; Multi-pass membrane protein Early endosome Note=Colocalizes with RAPGEF2 at the plasma membrane. Found in the Golgi upon GOPC overexpression (By similarity). In brain, expressed by glutamatergic and GABAergic neurons of the dorsal pons (at protein level). The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily. positive regulation of heart rate by epinephrine-norepinephrine positive regulation of the force of heart contraction by epinephrine-norepinephrine diet induced thermogenesis vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure positive regulation of the force of heart contraction by norepinephrine positive regulation of systemic arterial blood pressure G-protein coupled receptor activity adrenergic receptor activity beta1-adrenergic receptor activity Ras guanyl-nucleotide exchange factor activity protein binding nucleus cytoplasm endosome early endosome plasma membrane integral component of plasma membrane glycogen catabolic process apoptotic process signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway Rho protein signal transduction memory drug binding response to cold positive regulation of heart rate membrane integral component of membrane sensory perception of pain PDZ domain binding heat generation alpha-2A adrenergic receptor binding protein localization to organelle dopamine binding negative regulation of urine volume negative regulation of multicellular organism growth wound healing fear response positive regulation of apoptotic process intracellular membrane-bounded organelle positive regulation of GTPase activity positive regulation of adenylate cyclase activity positive regulation of heart contraction negative regulation of smooth muscle contraction positive regulation of saliva secretion protein heterodimerization activity brown fat cell differentiation epinephrine binding norepinephrine binding regulation of calcium ion transport lipid homeostasis inhibitory postsynaptic potential positive regulation of cell growth involved in cardiac muscle cell development adenylate cyclase-activating adrenergic receptor signaling pathway regulation of cardiac muscle cell contraction postsynapse G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential positive regulation of renin secretion into blood stream positive regulation of long-term synaptic potentiation positive regulation of calcium ion import across plasma membrane positive regulation of cation channel activity uc008hze.1 uc008hze.2 uc008hze.3 uc008hze.4 
ENSMUST00000038973.7 Gnptg ENSMUST00000038973.7 N-acetylglucosamine-1-phosphotransferase, gamma subunit, transcript variant 1 (from RefSeq NM_172529.3) A0A0R4J0H5 A0A0R4J0H5_MOUSE ENSMUST00000038973.1 ENSMUST00000038973.2 ENSMUST00000038973.3 ENSMUST00000038973.4 ENSMUST00000038973.5 ENSMUST00000038973.6 Gnptg NM_172529 uc008bab.1 uc008bab.2 uc008bab.3 uc008bab.4 Golgi membrane UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity membrane intracellular membrane-bounded organelle carbohydrate phosphorylation uc008bab.1 uc008bab.2 uc008bab.3 uc008bab.4 
ENSMUST00000039007.7 Trp53rka ENSMUST00000039007.7 transformation related protein 53 regulating kinase A (from RefSeq NM_001007581.2) 2810408M09Rik ENSMUST00000039007.1 ENSMUST00000039007.2 ENSMUST00000039007.3 ENSMUST00000039007.4 ENSMUST00000039007.5 ENSMUST00000039007.6 NM_001007581 Q5U452 Q5U452_MOUSE Trp53rka uc008nxu.1 uc008nxu.2 uc008nxu.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. BUD32 family. EKC/KEOPS complex p53 binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation tRNA threonylcarbamoyladenosine metabolic process uc008nxu.1 uc008nxu.2 uc008nxu.3 
ENSMUST00000039011.4 Uchl4 ENSMUST00000039011.4 ubiquitin carboxyl-terminal esterase L4 (from RefSeq NM_033607.1) ENSMUST00000039011.1 ENSMUST00000039011.2 ENSMUST00000039011.3 NM_033607 P58321 UCHL4_MOUSE uc009qbq.1 uc009qbq.2 Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Cytoplasm Expressed in various tissues at low level. Belongs to the peptidase C12 family. thiol-dependent ubiquitin-specific protease activity cytoplasm proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity uc009qbq.1 uc009qbq.2 
ENSMUST00000039013.15 Abca3 ENSMUST00000039013.15 ATP-binding cassette, sub-family A member 3, transcript variant 1 (from RefSeq NM_013855.3) ABCA3_MOUSE ENSMUST00000039013.1 ENSMUST00000039013.10 ENSMUST00000039013.11 ENSMUST00000039013.12 ENSMUST00000039013.13 ENSMUST00000039013.14 ENSMUST00000039013.2 ENSMUST00000039013.3 ENSMUST00000039013.4 ENSMUST00000039013.5 ENSMUST00000039013.6 ENSMUST00000039013.7 ENSMUST00000039013.8 ENSMUST00000039013.9 NM_013855 Q3U3L4 Q8R420 uc008avo.1 uc008avo.2 uc008avo.3 uc008avo.4 Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:17577581, PubMed:17540762, PubMed:17267394, PubMed:17142808, PubMed:20190032, PubMed:28034695). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:17142808). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (By similarity). Reaction=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:66344, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:64716, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66345; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:66272, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57643, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66273; Evidence=; Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence=; Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.; EC=7.6.2.2; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:66340, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:72999, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66341; Evidence=; Reaction=ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate; Xref=Rhea:RHEA:39051, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39052; Evidence=; Homooligomer; disulfide-linked. Endosome, multivesicular body membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane Late endosome membrane Lysosome membrane Note=Localized in the limiting membrane of lamellar bodies in lung alveolar type II cells (PubMed:11940594). Trafficks via the Golgi, sorting vesicles (SVs) and late endosome/multivesicular body network directly to the outer membrane of lamellar bodies in AT2 lung epithelial cells or to lysosomes and lysosomal-related organelles (LROs) in other cells where undergoes proteolytic cleavage and oligosaccharide processing from high mannose type to complex type. Oligomers formation takes place in a post- endoplasmic reticulum compartment (By similarity). Highly expressed in the lung and moderately expressed in the kidney, adipose, macrophage, and spleen. Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. N-glycosylated. Localization at intracellular vesicles is accompanied by processing of oligosaccharide from high mannose type to complex type. N-linked glycosylation at Asn-124 and Asn-140 is required for stability and efficient anterograde trafficking and prevents from proteasomal degradation. Proteolytically cleaved by CTSL and to a lower extent by CTSB within multivesicular bodies (MVB) and lamellar bodies (LB) leading to a mature form of 150 kDa. Homozygous knockout mice for ABCA3 are die within one hour after birth (PubMed:17577581, PubMed:17540762, PubMed:17267394). Mice develop respiratory failure immediately after birth with clinical signs such as gasping, cyanosis, failure to achieve inflation of the lung as visible through the skin and reduced motor activity and (PubMed:17577581, PubMed:17142808, PubMed:17267394). Conditional knockout mice in which ABCA3 is deleted in alveolar type II cells die shortly after birth from respiratory distress related to surfactant deficiency but approximately 30% of these mice survive after birth and develop emphysema in the absence of significant pulmonary inflammation (PubMed:20190032). Belongs to the ABC transporter superfamily. ABCA family. nucleotide binding lipid transporter activity ATP binding plasma membrane lipid transport membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances intracellular membrane-bounded organelle response to glucocorticoid transmembrane transport alveolar lamellar body alveolar lamellar body membrane uc008avo.1 uc008avo.2 uc008avo.3 uc008avo.4 
ENSMUST00000039016.14 Lzts2 ENSMUST00000039016.14 Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (from UniProt Q91YU6) AK169936 E9QKK6 ENSMUST00000039016.1 ENSMUST00000039016.10 ENSMUST00000039016.11 ENSMUST00000039016.12 ENSMUST00000039016.13 ENSMUST00000039016.2 ENSMUST00000039016.3 ENSMUST00000039016.4 ENSMUST00000039016.5 ENSMUST00000039016.6 ENSMUST00000039016.7 ENSMUST00000039016.8 ENSMUST00000039016.9 Kiaa1813 LZTS2_MOUSE Lapser1 Q569X6 Q91YU6 uc008hqn.1 uc008hqn.2 uc008hqn.3 uc008hqn.4 Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. Interacts with KATNB1. Also interacts with CTNNB1, gamma- tubulin and KIF23. Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis. Belongs to the LZTS2 family. Sequence=BAC98256.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; mitotic cytokinesis kidney development cytoplasm centrosome microtubule organizing center cytosol cytoskeleton microtubule plasma membrane cell cycle negative regulation of cell proliferation positive regulation of cell death Wnt signaling pathway negative regulation of Wnt signaling pathway midbody vesicle microtubule severing nuclear export spindle midzone assembly cell division primary ureteric bud growth ureter morphogenesis negative regulation of canonical Wnt signaling pathway negative regulation of protein localization to nucleus uc008hqn.1 uc008hqn.2 uc008hqn.3 uc008hqn.4 
ENSMUST00000039026.8 Apln ENSMUST00000039026.8 apelin (from RefSeq NM_013912.4) APEL_MOUSE Apel ENSMUST00000039026.1 ENSMUST00000039026.2 ENSMUST00000039026.3 ENSMUST00000039026.4 ENSMUST00000039026.5 ENSMUST00000039026.6 ENSMUST00000039026.7 NM_013912 Q9R0R4 uc009tbu.1 uc009tbu.2 uc009tbu.3 This gene encodes the neuropeptide Apelin, an endogenous ligand of the G protein-coupled receptor APJ. This gene is highly expressed in the central nervous system and peripheral tissues and the encoded preproprotein undergoes proteolytic processing to generate mature peptides of different sizes that are secreted into the plasma. These peptides play important roles in a broad range of physiological processes such as cardiac contractility, blood pressure, blood vessel growth, appetite and drink behavior, and pituitary hormone secretion. Mice lacking the encoded protein develop progressive heart failure and exhibit a shorter bleeding time, prothrombotic profile and increased bone mass. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ832282.1, SRR1660813.203415.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Endogenous ligand for the apelin receptor (APLNR). Drives internalization of APLNR (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross- linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (PubMed:10525157). Plays a role in early coronary blood vessels formation (PubMed:28890073). Mediates myocardial contractility in an ERK1/2- dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (PubMed:11359874). Secreted Secreted, extracellular space Note=Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk. Expressed in extraembryonic visceral endoderm and in the primitive streak at 6.5 and 7.5 dpc (PubMed:28854362). Expressed in the anterior visceral yolk sac at 8.25 dpc (PubMed:28854362). Expressed weakly in the embryonic heart at 11.5 dpc (PubMed:26611206). Expressed in the adult heart (PubMed:26611206). Expressed in endothelial cells and cardiomyocytes and weakly expressed in fibroblasts (PubMed:26611206). Not up-regulated following myocardial infarction (MI) (at protein level) (PubMed:26611206). Several active peptides may be produced by proteolytic processing of the peptide precursor. Mice heart of embryos show increased coronary vessel growth at 13.5 dpc and 15.5 dpc (PubMed:28890073). Double knockout mice of APELA and APLN genes exhibit the same penetrance, embryonic lethality and cardiovascular malformations as single APELA knockout mice (PubMed:28854362). Belongs to the apelin family. angiogenesis regulation of the force of heart contraction receptor binding hormone activity extracellular region extracellular space signal transduction G-protein coupled receptor signaling pathway multicellular organism development gastrulation feeding behavior positive regulation of cell proliferation negative regulation of gene expression positive regulation of heat generation apelin receptor binding negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of phosphorylation drinking behavior protein homodimerization activity regulation of respiratory gaseous exchange negative regulation of blood pressure positive regulation of heart contraction negative regulation of vasoconstriction perinuclear region of cytoplasm regulation of body fluid levels positive regulation of corticotropin secretion positive regulation of corticotropin-releasing hormone secretion apelin receptor signaling pathway coronary vasculature development positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of G-protein coupled receptor internalization negative regulation of vascular smooth muscle cell proliferation positive regulation of vascular endothelial cell proliferation uc009tbu.1 uc009tbu.2 uc009tbu.3 
ENSMUST00000039044.2 Uts2r ENSMUST00000039044.2 urotensin 2 receptor (from RefSeq NM_145440.1) ENSMUST00000039044.1 Gpr14 NM_145440 Q8VIH9 UR2R_MOUSE uc007mvj.1 uc007mvj.2 High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. urotensin II receptor activity negative regulation of glomerular filtration G-protein coupled receptor activity early endosome plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway regulation of blood pressure G-protein coupled peptide receptor activity positive regulation of circadian sleep/wake cycle, wakefulness membrane integral component of membrane positive regulation of cell growth negative regulation of urine volume negative regulation of renal sodium excretion positive regulation of angiogenesis negative regulation of blood pressure positive regulation of blood pressure positive regulation of vasoconstriction positive regulation of circadian sleep/wake cycle, REM sleep positive regulation of fibroblast proliferation recycling endosome regulation of blood vessel diameter uc007mvj.1 uc007mvj.2 
ENSMUST00000039046.10 Il17f ENSMUST00000039046.10 interleukin 17F (from RefSeq NM_145856.2) ENSMUST00000039046.1 ENSMUST00000039046.2 ENSMUST00000039046.3 ENSMUST00000039046.4 ENSMUST00000039046.5 ENSMUST00000039046.6 ENSMUST00000039046.7 ENSMUST00000039046.8 ENSMUST00000039046.9 IL17F_MOUSE NM_145856 Q7TNI7 Q8K4C3 uc007ala.1 uc007ala.2 uc007ala.3 Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:23255360, PubMed:18025225, PubMed:19144317). IL17A- IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6- mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:17911633, PubMed:15477493, PubMed:18025225). IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation (PubMed:18025225, PubMed:23255360). As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (PubMed:18025225). Stimulates the production of antimicrobial beta- defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317). IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF- kappa-B signaling pathway (PubMed:28813677). Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (PubMed:28813677). Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (PubMed:32076265). Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes (PubMed:29915298). Homodimer; disulfide-linked (By similarity). Heterodimer with IL17A (IL17A-IL17F) (PubMed:18025225). Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule (By similarity). IL17F homodimer forms predominantly complexes with IL17RC homodimer, whereas IL17A-IL17F favors complexes with IL17RA-IL17RC (By similarity). IL17RA and IL17RC chains cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (By similarity). Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TNI7-1; Sequence=Displayed; Name=2; IsoId=Q7TNI7-2; Sequence=VSP_037499; Expressed by T-helper 17 cells (Th17) (at protein level). The expression pattern reflects the differentiation state. In fully differentiated Th17 cells, IL17A-IL17F heterodimers are produced at higher levels than IL17A-IL17A and IL17F-IL17F dimers (PubMed:18025225). Dominantly secreted in intestine (PubMed:29915298). Expressed by resident cells of the lamina propria, both epithelial cells and immune cell subsets including natural killer cells, dendritic cells, macrophages and various T and B cell subsets (PubMed:29915298, PubMed:16990136). Expressed by epithelial cells and innate immune cells in the colon (PubMed:19144317). Expressed in group 3 innate lymphoid cells (PubMed:23255360, PubMed:29915298). Induced upon antigen receptor binding in the presence of IL6 and TGB1 (PubMed:16990136, PubMed:18025225). Up-regulated by IL23A- IL12B, IL1B and TNF and inhibited by IFNG and IL4 in CD4-positive T cells (PubMed:18025225). Induced upon fungal infection in innate lymphoid cells (PubMed:23255360). Induced in lung epithelial cells upon bacterial and fungal infection (PubMed:28813677). Induced in brown adipose tissue upon cold exposure (PubMed:32076265). Mutant mice are born healthy at the expected Mendelian ratio, are fertile, and have no apparent phenotypic abnormalities (PubMed:19144317). They show increased susceptibility to S.aureus upper respiratory infection (PubMed:28813677). Mutant mice are protected from chemically induced colitis, a model of human inflammatory bowel disease (PubMed:29915298). Belongs to the IL-17 family. cytokine activity cytokine receptor binding extracellular region extracellular space inflammatory response signal transduction negative regulation of angiogenesis regulation of transforming growth factor beta receptor signaling pathway cytokine binding cytokine biosynthetic process lymphotoxin A biosynthetic process protein homodimerization activity regulation of interleukin-2 biosynthetic process regulation of interleukin-6 biosynthetic process regulation of interleukin-8 biosynthetic process regulation of granulocyte macrophage colony-stimulating factor biosynthetic process positive regulation of transcription from RNA polymerase II promoter cartilage development positive regulation of cytokine production involved in inflammatory response positive regulation of interleukin-6 secretion uc007ala.1 uc007ala.2 uc007ala.3 
ENSMUST00000039047.5 Serpini2 ENSMUST00000039047.5 serine (or cysteine) peptidase inhibitor, clade I, member 2 (from RefSeq NM_026460.3) ENSMUST00000039047.1 ENSMUST00000039047.2 ENSMUST00000039047.3 ENSMUST00000039047.4 NM_026460 Q9D8Z3 Q9D955 Q9JK88 SPI2_MOUSE Spi14 uc008pna.1 uc008pna.2 uc008pna.3 uc008pna.4 Secreted Expressed in pancreas. Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular region extracellular space negative regulation of peptidase activity negative regulation of endopeptidase activity regulation of cell adhesion peptidase inhibitor activity uc008pna.1 uc008pna.2 uc008pna.3 uc008pna.4 
ENSMUST00000039048.2 1810055G02Rik ENSMUST00000039048.2 RIKEN cDNA 1810055G02 gene, transcript variant 1 (from RefSeq NM_028077.4) CK024_MOUSE ENSMUST00000039048.1 NM_028077 Q8VCP2 Q9D8N1 uc008fwt.1 uc008fwt.2 Cell membrane ; Single-pass type I membrane protein Golgi apparatus, trans-Golgi network membrane ; Single-pass type I membrane protein Note=Cycles to the plasma membrane via endosomes in a pH sensitive manner. Associated with Rab6-positive vesicles (By similarity). molecular_function cellular_component Golgi apparatus plasma membrane biological_process membrane integral component of membrane uc008fwt.1 uc008fwt.2 
ENSMUST00000039049.16 Syngr4 ENSMUST00000039049.16 synaptogyrin 4, transcript variant 1 (from RefSeq NM_021482.2) A0A0R4J0K3 A0A0R4J0K3_MOUSE ENSMUST00000039049.1 ENSMUST00000039049.10 ENSMUST00000039049.11 ENSMUST00000039049.12 ENSMUST00000039049.13 ENSMUST00000039049.14 ENSMUST00000039049.15 ENSMUST00000039049.2 ENSMUST00000039049.3 ENSMUST00000039049.4 ENSMUST00000039049.5 ENSMUST00000039049.6 ENSMUST00000039049.7 ENSMUST00000039049.8 ENSMUST00000039049.9 NM_021482 Syngr4 uc009gxp.1 uc009gxp.2 uc009gxp.3 Membrane ulti-pass membrane protein Belongs to the synaptogyrin family. membrane integral component of membrane uc009gxp.1 uc009gxp.2 uc009gxp.3 
ENSMUST00000039059.8 Pcsk7 ENSMUST00000039059.8 proprotein convertase subtilisin/kexin type 7, transcript variant 2 (from RefSeq NM_008794.2) ENSMUST00000039059.1 ENSMUST00000039059.2 ENSMUST00000039059.3 ENSMUST00000039059.4 ENSMUST00000039059.5 ENSMUST00000039059.6 ENSMUST00000039059.7 NM_008794 O08577 PCSK7_MOUSE Pc7 Q61139 Q922W4 uc009pgp.1 uc009pgp.2 uc009pgp.3 uc009pgp.4 Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Inhibited by zinc and copper. Golgi apparatus, trans-Golgi network membrane ; Single-pass type I membrane protein Note=Seems to be localized intracellularly to the trans Golgi network. Widely expressed. Expressed in brain, lung, muscle, heart, liver, kidney, spleen and thymus. Ubiquitously expressed at constitutive levels during embryogenesis. Belongs to the peptidase S8 family. serine-type endopeptidase activity endoplasmic reticulum lumen Golgi apparatus trans-Golgi network proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane protein processing hydrolase activity integral component of Golgi membrane uc009pgp.1 uc009pgp.2 uc009pgp.3 uc009pgp.4 
ENSMUST00000039061.15 Trappc11 ENSMUST00000039061.15 trafficking protein particle complex 11 (from RefSeq NM_177240.3) B2RXC1 B9EJS1 ENSMUST00000039061.1 ENSMUST00000039061.10 ENSMUST00000039061.11 ENSMUST00000039061.12 ENSMUST00000039061.13 ENSMUST00000039061.14 ENSMUST00000039061.2 ENSMUST00000039061.3 ENSMUST00000039061.4 ENSMUST00000039061.5 ENSMUST00000039061.6 ENSMUST00000039061.7 ENSMUST00000039061.8 ENSMUST00000039061.9 NM_177240 Q52KP8 Q8BXY8 TPC11_MOUSE uc009lra.1 uc009lra.2 uc009lra.3 Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Golgi apparatus Golgi apparatus, cis-Golgi network Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B2RXC1-1; Sequence=Displayed; Name=2; IsoId=B2RXC1-2; Sequence=VSP_035100, VSP_035101, VSP_035102; Belongs to the TRAPPC11 family. molecular_function Golgi apparatus ER to Golgi vesicle-mediated transport Golgi organization vesicle-mediated transport TRAPP complex protein oligomerization regulation of protein complex stability uc009lra.1 uc009lra.2 uc009lra.3 
ENSMUST00000039064.8 Fam124a ENSMUST00000039064.8 family with sequence similarity 124, member A (from RefSeq NM_001243857.1) D3Z5V4 D3Z5V4_MOUSE ENSMUST00000039064.1 ENSMUST00000039064.2 ENSMUST00000039064.3 ENSMUST00000039064.4 ENSMUST00000039064.5 ENSMUST00000039064.6 ENSMUST00000039064.7 Fam124a NM_001243857 uc029skq.1 uc029skq.2 uc029skq.3 Belongs to the FAM124 family. molecular_function cellular_component biological_process uc029skq.1 uc029skq.2 uc029skq.3 
ENSMUST00000039071.3 Cacng5 ENSMUST00000039071.3 calcium channel, voltage-dependent, gamma subunit 5, transcript variant 1 (from RefSeq NM_001199301.1) CCG5_MOUSE ENSMUST00000039071.1 ENSMUST00000039071.2 NM_001199301 Q8VHW4 uc007mbc.1 uc007mbc.2 uc007mbc.3 Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By similarity). Membrane ; Multi-pass membrane protein Postsynaptic density membrane Brain. Enriched in Bergman glia, as well as a variety of neuronal populations including locus coeruleus, olfactory bulb, lateral septal nucleus, interpeduncular nucleus, and the CA2 and rostral/medial CA1 regions of hippocampus. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. voltage-gated ion channel activity calcium channel activity plasma membrane ion transport calcium ion transport postsynaptic density membrane integral component of membrane cell junction AMPA glutamate receptor complex regulation of ion transmembrane transport synapse postsynaptic membrane calcium ion transmembrane transport regulation of postsynaptic neurotransmitter receptor activity glutamatergic synapse integral component of postsynaptic membrane regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc007mbc.1 uc007mbc.2 uc007mbc.3 
ENSMUST00000039075.8 Spag11b ENSMUST00000039075.8 sperm associated antigen 11B, transcript variant 1 (from RefSeq NM_001286493.1) ENSMUST00000039075.1 ENSMUST00000039075.2 ENSMUST00000039075.3 ENSMUST00000039075.4 ENSMUST00000039075.5 ENSMUST00000039075.6 ENSMUST00000039075.7 Ep2 Ep2c/h NM_001286493 Q2HPE2 Q3UW43 SG11B_MOUSE Spag11b Spag11c uc009lae.1 uc009lae.2 uc009lae.3 uc009lae.4 uc009lae.5 Has antimicrobial activity against E.coli (By similarity). Plays a role in the defense response in the male reproductive tract, contributing to sperm maturation, storage and protection (By similarity). Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UW43-1; Sequence=Displayed; Name=2; IsoId=Q3UW43-2; Sequence=VSP_061386, VSP_061387, VSP_061388; Belongs to the beta-defensin family. molecular_function cellular_component extracellular region cytolysis in other organism uc009lae.1 uc009lae.2 uc009lae.3 uc009lae.4 uc009lae.5 
ENSMUST00000039080.4 8430432A02Rik ENSMUST00000039080.4 8430432A02Rik (from geneSymbol) AK018453 ENSMUST00000039080.1 ENSMUST00000039080.2 ENSMUST00000039080.3 uc287hrx.1 uc287hrx.2 uc287hrx.1 uc287hrx.2 
ENSMUST00000039088.9 Tex19.1 ENSMUST00000039088.9 testis expressed gene 19.1 (from RefSeq NM_028602.3) ENSMUST00000039088.1 ENSMUST00000039088.2 ENSMUST00000039088.3 ENSMUST00000039088.4 ENSMUST00000039088.5 ENSMUST00000039088.6 ENSMUST00000039088.7 ENSMUST00000039088.8 NM_028602 Q7TPF0 Q99MV2 TX19A_MOUSE Tex19 Tex19.1 Tex19a uc007mvi.1 uc007mvi.2 uc007mvi.3 uc007mvi.4 Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and preventing their mobilization (PubMed:18802469, PubMed:21103378, PubMed:23364048, PubMed:23674551, PubMed:28254886). With its paralog, Tex19.2, collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:28254886). Also during spermatogenesis, promotes, with UBR2, SPO11-dependent meiotic recombination (PubMed:28708824). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE- 1 retrotransposon mobilization (PubMed:28806172). Interacts with UBR2; does not lead to Tex19.1 degradation and stabilizes it (PubMed:21103378). Interacts with piRNA-associated proteins DDX4, EDC4, MAEL, PIWIL1, PIWIL2, RANBP9 and TDRD6 (PubMed:28254886). Interacts with L1RE1 (PubMed:28806172). Cytoplasm Note=Was initially reported to localize in the nucleus (PubMed:18096721). However, it was later shown to localize in cytoplasm only (PubMed:18802469). Cytoplasmic localization is distinct from the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (PubMed:18802469). Expressed in testis, placenta and ovary. Expressed in pluripotent stem cells. In testis, expression is highest in mitotic spermatogonia, decreases as spermatocytes progress through meiosis, and is present at low levels in round spermatids (at protein level). Expressed in early embryo and is later limited to the germ line. Expressed in the ectoderm and then in primordial germ cells (PGCs). Expressed in testis from 13.5 dpc to adulthood in gonocytes and spermatocytes. Also present in the developing and adult ovary as well as in the placenta and its precursor tissue, the ectoplacental cone. Expression is down-regulated by DAZL protein, which binds to 3'UTR of Tex19.1 mRNAs and probably represses its translation. Mutant embryos exhibit intra-uterine growth retardation and have small placentas due to a reduction in the number of spongiotrophoblast, glycogen trophoblast and sinusoidal trophoblast giant cells. They show an incomplete penetrance of embryonic lethality preferentially affecting females. Knockout have heterogeneous spermatogenic defects and testicular degeneration leading to infertility in the most severe cases. During spermatogenesis, mutants show impaired recombination during leptotene stage of meiotic prophase leading to chromosome asynapsis. Knockout females are fertile (PubMed:23364048, PubMed:23674551, PubMed:18802469, PubMed:21103378, PubMed:28708824). Males deficient for both Tex19.1 and Tex19.2 have impaired spermatogenesis, small testes and are infertile. They show vacuolization and seminiferous epithelium degeneration as early as P16. They have defects in meiotic chromosome synapsis, persistence of DNA double-strand breaks during meiosis, lack of post-meiotic germ cell and up-regulation of MMERVK10C retrotransposon expression. Number of females deficient for both for Tex19.1 and Tex19.2 that survive 2 weeks or more is reduced compared to males. Females display normal fertility. Surviving mutants do not present gross somatic abnormalities (PubMed:28254886). in utero embryonic development placenta development RNA binding protein binding nucleus cytoplasm synapsis reciprocal meiotic recombination male meiosis spermatogenesis male gonad development negative regulation of transposition posttranscriptional regulation of gene expression sexual reproduction cell differentiation piRNA binding meiotic cell cycle spongiotrophoblast cell proliferation cell proliferation involved in embryonic placenta development uc007mvi.1 uc007mvi.2 uc007mvi.3 uc007mvi.4 
ENSMUST00000039093.10 Zmynd15 ENSMUST00000039093.10 zinc finger, MYND-type containing 15, transcript variant 1 (from RefSeq NM_001029929.3) ENSMUST00000039093.1 ENSMUST00000039093.2 ENSMUST00000039093.3 ENSMUST00000039093.4 ENSMUST00000039093.5 ENSMUST00000039093.6 ENSMUST00000039093.7 ENSMUST00000039093.8 ENSMUST00000039093.9 NM_001029929 Q3TAD1 Q8C0R7 ZMY15_MOUSE uc007juy.1 uc007juy.2 uc007juy.3 Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May regulate haploid genes important for spermiogenesis. Interacts with HDAC1, HDAC3, HDAC6 and, to a lesser extent, with HDAC7. Nucleus Cytoplasm Note=In step 9-11 spermatids, shifts from nucleus to cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C0R7-1; Sequence=Displayed; Name=2; IsoId=Q8C0R7-2; Sequence=VSP_042145, VSP_042146; Testis-specific. Expressed in pachytene spermatocytes and all developing spermatids, but not in Sertoli, nor Leydig cells (at protein level). At the mRNA level, first detected in early pachytene spermatocytes. At the protein level, first detected in step 2 round spermatids. Expression continuously increases thereafter and peaks in spermatids at steps 7-9 (at protein level). Levels start to decrease after step 9 and in step 9-11 elongating spermatids (at protein level). Since CXCL16 and ZMYND15 genes overlap in their 5'UTRs, CXCL16 knockout also disrupts the ZMYND15 gene. The double knockout mice display severe depletion of late spermatids and are thus infertile. This phenotype is probably due to ZMYND15, rather than CXCL16, deficiency. nucleus cytoplasm spermatogenesis spermatid development cell differentiation histone deacetylase binding negative regulation of transcription, DNA-templated metal ion binding uc007juy.1 uc007juy.2 uc007juy.3 
ENSMUST00000039101.12 Rwdd2b ENSMUST00000039101.12 RWD domain containing 2B (from RefSeq NM_016924.2) ENSMUST00000039101.1 ENSMUST00000039101.10 ENSMUST00000039101.11 ENSMUST00000039101.2 ENSMUST00000039101.3 ENSMUST00000039101.4 ENSMUST00000039101.5 ENSMUST00000039101.6 ENSMUST00000039101.7 ENSMUST00000039101.8 ENSMUST00000039101.9 NM_016924 ORF5 Q99M03 Q9JLH4 RWD2B_MOUSE uc007zui.1 uc007zui.2 uc007zui.3 molecular_function cellular_component biological_process uc007zui.1 uc007zui.2 uc007zui.3 
ENSMUST00000039113.14 Pdia2 ENSMUST00000039113.14 protein disulfide isomerase associated 2 (from RefSeq NM_001081070.1) D3Z6P0 ENSMUST00000039113.1 ENSMUST00000039113.10 ENSMUST00000039113.11 ENSMUST00000039113.12 ENSMUST00000039113.13 ENSMUST00000039113.2 ENSMUST00000039113.3 ENSMUST00000039113.4 ENSMUST00000039113.5 ENSMUST00000039113.6 ENSMUST00000039113.7 ENSMUST00000039113.8 ENSMUST00000039113.9 NM_001081070 PDIA2_MOUSE Pdia2 Pdip Q14AV9 uc008bdo.1 uc008bdo.2 Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity). Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; Evidence=; Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Endoplasmic reticulum lumen Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=D3Z6P0-1; Sequence=Displayed; Name=2 ; IsoId=D3Z6P0-2; Sequence=VSP_039293; Highly expressed in pancreas. Glycosylated. Belongs to the protein disulfide isomerase family. protein disulfide isomerase activity steroid binding endoplasmic reticulum endoplasmic reticulum lumen protein folding lipid binding peptide disulfide oxidoreductase activity isomerase activity response to endoplasmic reticulum stress cell redox homeostasis oxidation-reduction process uc008bdo.1 uc008bdo.2 
ENSMUST00000039118.7 Zic5 ENSMUST00000039118.7 zinc finger protein of the cerebellum 5 (from RefSeq NM_022987.3) A0A0R4J0E2 A0A0R4J0E2_MOUSE ENSMUST00000039118.1 ENSMUST00000039118.2 ENSMUST00000039118.3 ENSMUST00000039118.4 ENSMUST00000039118.5 ENSMUST00000039118.6 NM_022987 Zic5 uc007vbb.1 uc007vbb.2 uc007vbb.3 uc007vbb.4 Belongs to the GLI C2H2-type zinc-finger protein family. nucleic acid binding uc007vbb.1 uc007vbb.2 uc007vbb.3 uc007vbb.4 
ENSMUST00000039121.4 Fam170a ENSMUST00000039121.4 family with sequence similarity 170, member A, transcript variant 1 (from RefSeq NM_001004061.2) B2RW56 ENSMUST00000039121.1 ENSMUST00000039121.2 ENSMUST00000039121.3 F170A_MOUSE Gm93 NM_001004061 Q66LM6 Q66LM7 Znfd uc008ewx.1 uc008ewx.2 uc008ewx.3 Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=b; IsoId=Q66LM6-1; Sequence=Displayed; Name=2; Synonyms=a; IsoId=Q66LM6-2; Sequence=VSP_032558; Testis-specific. The N-terminus is necessary for nuclear localization. The C- terminus is necessary for transcriptional activity (By similarity). Belongs to the FAM170 family. DNA binding nucleus transcription from RNA polymerase II promoter positive regulation of transcription, DNA-templated metal ion binding uc008ewx.1 uc008ewx.2 uc008ewx.3 
ENSMUST00000039132.9 Zfp472 ENSMUST00000039132.9 zinc finger protein 472 (from RefSeq NM_153063.3) B0V2W5 B0V2W5_MOUSE ENSMUST00000039132.1 ENSMUST00000039132.2 ENSMUST00000039132.3 ENSMUST00000039132.4 ENSMUST00000039132.5 ENSMUST00000039132.6 ENSMUST00000039132.7 ENSMUST00000039132.8 NM_153063 Zfp472 uc008bxv.1 uc008bxv.2 uc008bxv.3 uc008bxv.4 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc008bxv.1 uc008bxv.2 uc008bxv.3 uc008bxv.4 
ENSMUST00000039135.6 Dock5 ENSMUST00000039135.6 dedicator of cytokinesis 5 (from RefSeq NM_177780.3) B2RY04 DOCK5_MOUSE Dock5 E9QLI4 ENSMUST00000039135.1 ENSMUST00000039135.2 ENSMUST00000039135.3 ENSMUST00000039135.4 ENSMUST00000039135.5 Lr2 NM_177780 Rlc uc007ull.1 uc007ull.2 uc007ull.3 Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (PubMed:18396277). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (By similarity). Interacts with CRK and CRKL (By similarity). Interacts (via N- terminus) with tensin TNS3 (via N-terminus); the interaction increases DOCK5 guanine nucleotide exchange activity towards Rac (PubMed:27505886). Interacts with ELMO1 (PubMed:27505886). Cytoplasm Cell membrane Cell projection, podosome Note=Associated with the edge of the plasma membrane in intestinal epithelial cells spreading on type IV collagen. Highly expressed in lens, where it predominantly localizes to anterior epithelial cells, and is weakly expressed in lens fiber (at protein level). Expressed in brain, eye, lung, spleen and kidney, but not in thymus or peripheral blood leukocytes. In the lens, expressed from 15.5 dpc to maturity (PubMed:18396277). Expression increases during osteoclast differentiation (PubMed:27505886). The DOCKER domain may mediate some GEF activity. Note=Defects in Dock5 are the cause of rupture of lens cataract. It affects both eyes and is inherited as an autosomal recessive trait. Homozygotes spontaneously develop opacity of the lens at 35-60 days of age. The initial pathological changes appear at about 35 days of age in the deep layer of the posterior cortex as irregular swelling, condensation, degeneration and fragmentation of the lens fibers, leading to rupture of the lens capsule at the posterior pole at 45-100 days of age. Following rupture, the lens nucleus becomes dislocated behind the lens or occasionally in the anterior chamber. Belongs to the DOCK family. guanyl-nucleotide exchange factor activity GTPase activator activity cytoplasm cytosol plasma membrane small GTPase mediated signal transduction positive regulation of epithelial cell migration membrane cell migration positive regulation of GTPase activity positive regulation of substrate adhesion-dependent cell spreading negative regulation of vascular smooth muscle contraction positive regulation of vascular associated smooth muscle cell migration uc007ull.1 uc007ull.2 uc007ull.3 
ENSMUST00000039144.7 Clstn1 ENSMUST00000039144.7 calsyntenin 1, transcript variant 1 (from RefSeq NM_023051.5) A2A800 B2KFP1 B2KFP2 CSTN1_MOUSE Clstn1 Cs1 Cstn1 ENSMUST00000039144.1 ENSMUST00000039144.2 ENSMUST00000039144.3 ENSMUST00000039144.4 ENSMUST00000039144.5 ENSMUST00000039144.6 Kiaa0911 NM_023051 Q69ZV9 Q7TS67 Q8K103 Q9EPL2 uc008vwo.1 uc008vwo.2 uc008vwo.3 uc008vwo.4 Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (PubMed:11161476, PubMed:24613359). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles (PubMed:17332754). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (PubMed:11161476, PubMed:12972431). [Soluble Alc-alpha]: As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. [CTF1-alpha]: In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. Directly interacts with APBA2 (PubMed:12972431). Forms a tripartite complex with APBA2 and APP (PubMed:12972431). The CTF1 chain interacts with PSEN1. Interacts with KLC1 and APBB1 (PubMed:16760430, PubMed:17332754). [Soluble Alc-alpha]: Interacts with APBB1; this interaction stabilizes AlcICD metabolism. [CTF1-alpha]: Interacts with PSEN1. Q9EPL2; Q8CD76: Klc1; NbExp=3; IntAct=EBI-2013142, EBI-6271950; Postsynaptic cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane ; Single-pass type I membrane protein Cell projection, neuron projection Vesicle Note=Localized in the postsynaptic membrane of both excitatory and inhibitory synapses. [Soluble Alc-alpha]: Nucleus Note=The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EPL2-1; Sequence=Displayed; Name=2; IsoId=Q9EPL2-2; Sequence=VSP_032036; Highly expressed in the brain (at protein level), with over 90% of the neurons expressing detectable amounts. In the brain, relatively high levels in the cerebral cortex, striatum, hippocampus and thalamus. Moderate levels in the cerebellum. Low levels in the olfactory bulb, midbrain and pons (at protein level). Not detected in Purkinje cells. Expressed at low levels in the lung (at protein level). At the mRNA level, weakly detected in the kidney, lung, skeletal muscle, heart and testis. Not expressed in the sciatic nerve fiber. Expression in the brain gradually increases during the first postnatal week, reaching a peak at P7. In the gray matter, highly expressed in both developing and adult brain. In the white matter, at P6 highly expressed in all major fiber tracts, including the anterior commissure and the corpus callosum, as well as the external and internal capsules, while in the adult, axonal expression in fiber tracts is only faint (at protein level). The cytoplasmic domain binds synaptic Ca(2+). Proteolytically processed under normal cellular conditions (PubMed:11161476, PubMed:15037614). A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C- terminal transmembrane fragment (CTF1) (PubMed:11161476, PubMed:15037614). A secondary cleavage catalyzed by presenilin gamma- secretase within the transmembrane domain releases the beta-Alc-alpha chain in the extracellular milieu and produces an intracellular fragment (AlcICD) (PubMed:11161476, PubMed:15037614). Beta-Alc-alpha secretion is largely dependent upon PSEN1 and PSEN2 (PubMed:11161476, PubMed:15037614). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1 (PubMed:11161476, PubMed:15037614). Mice lacking Clstn1, Clstn2 and Clstn3 display behavior disorders, characterized by hyperactivity in normal environment, hypersensitivity to stress, and show tendency to freeze in novel environments. Belongs to the calsyntenin family. Sequence=BAD32337.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane beta-amyloid binding regulation of cell growth calcium ion binding protein binding extracellular region extracellular space nucleus endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane cellular calcium ion homeostasis cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules chemical synaptic transmission cell surface postsynaptic density membrane integral component of membrane kinesin binding cell junction X11-like protein binding cell projection synapse postsynaptic membrane positive regulation of synaptic transmission positive regulation of synapse assembly regulation of synapse maturation postsynaptic endosome neurotransmitter receptor transport to postsynaptic membrane glutamatergic synapse GABA-ergic synapse vesicle-mediated transport in synapse integral component of postsynaptic density membrane integral component of spine apparatus membrane uc008vwo.1 uc008vwo.2 uc008vwo.3 uc008vwo.4 
ENSMUST00000039146.4 Tex19.2 ENSMUST00000039146.4 testis expressed gene 19.2 (from RefSeq NM_027622.3) ENSMUST00000039146.1 ENSMUST00000039146.2 ENSMUST00000039146.3 NM_027622 Q9D5S1 TX19B_MOUSE Tex19b uc007mvh.1 uc007mvh.2 uc007mvh.3 May be required during spermatogenesis, probably by participating in the repression of retrotransposable elements and prevent their mobilization (Probable). With its paralog, Tex19.1, collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:28254886). Interacts with UBR2 (PubMed:21103378). Interacts with piRNA- associated proteins DDX4, EDC4, MAEL, PIWIL1, PIWIL2, RANBP9 and TDRD6 (Probable). Cytoplasm Note=Was initially reported to localize in the nucleus. Specifically expressed in somatic cells of male gonad lineage. Expressed in the ectoderm and then in primordial germ cells (PGCs). Expressed in testis from embryos (13.5 dpc) to adulthood in gonocytes and spermatocytes. Males deficient for both for Tex19.1 and Tex19.2 have impaired spermatogenesis, small testes and are infertile. They show vacuolization and seminiferous epithelium degeneration as early as P16. They have defects in meiotic chromosome synapsis, persistence of DNA double-strand breaks during meiosis, lack of post-meiotic germ cell and up-regulation of MMERVK10C retrotransposon expression. Number of females double knockout for Tex19.1 and Tex19.2 surviving 2 weeks or more is reduced compared to males. Females display normal fertility. Surviving mutants do not present gross somatic abnormalities. placenta development RNA binding protein binding nucleus cytoplasm male meiosis spermatogenesis male gonad development negative regulation of transposition cell differentiation piRNA binding meiotic cell cycle uc007mvh.1 uc007mvh.2 uc007mvh.3 
ENSMUST00000039152.14 Dhx8 ENSMUST00000039152.14 DEAH-box helicase 8 (from RefSeq NM_144831.2) A2A4P0 DHX8_MOUSE ENSMUST00000039152.1 ENSMUST00000039152.10 ENSMUST00000039152.11 ENSMUST00000039152.12 ENSMUST00000039152.13 ENSMUST00000039152.2 ENSMUST00000039152.3 ENSMUST00000039152.4 ENSMUST00000039152.5 ENSMUST00000039152.6 ENSMUST00000039152.7 ENSMUST00000039152.8 ENSMUST00000039152.9 NM_144831 uc007lpr.1 uc007lpr.2 uc007lpr.3 uc007lpr.4 Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Identified in the spliceosome C complex. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with SRRM2. Interacts with CACTIN. Nucleus The RS domain confers a nuclear localization signal, and appears to facilitate the interaction with the spliceosome. Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily. nucleotide binding spliceosomal complex disassembly mRNA splicing, via spliceosome nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus nucleoplasm spliceosomal complex mRNA processing RNA splicing nuclear body hydrolase activity identical protein binding U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome uc007lpr.1 uc007lpr.2 uc007lpr.3 uc007lpr.4 
ENSMUST00000039156.7 Phpt1 ENSMUST00000039156.7 phosphohistidine phosphatase 1, transcript variant 7 (from RefSeq NR_184826.1) ENSMUST00000039156.1 ENSMUST00000039156.2 ENSMUST00000039156.3 ENSMUST00000039156.4 ENSMUST00000039156.5 ENSMUST00000039156.6 NR_184826 PHP14_MOUSE Php14 Q9DAK9 uc008isp.1 uc008isp.2 uc008isp.3 Exhibits phosphohistidine phosphatase activity. Reaction=H2O + N(pros)-phospho-L-histidyl-[protein] = L-histidyl- [protein] + phosphate; Xref=Rhea:RHEA:47964, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:9746, ChEBI:CHEBI:15377, ChEBI:CHEBI:29979, ChEBI:CHEBI:43474, ChEBI:CHEBI:64837; EC=3.9.1.3; Evidence=; Reaction=H2O + N(tele)-phospho-L-histidyl-[protein] = L-histidyl- [protein] + phosphate; Xref=Rhea:RHEA:47960, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:10719, ChEBI:CHEBI:15377, ChEBI:CHEBI:29979, ChEBI:CHEBI:43474, ChEBI:CHEBI:83586; EC=3.9.1.3; Evidence=; Monomer. Cytoplasm Belongs to the janus family. phosphoprotein phosphatase activity cytoplasm cytosol protein dephosphorylation hydrolase activity calcium channel inhibitor activity positive regulation of insulin secretion involved in cellular response to glucose stimulus peptidyl-histidine dephosphorylation ion channel binding negative regulation of T cell receptor signaling pathway negative regulation of lyase activity protein histidine phosphatase activity positive regulation of cell motility regulation of actin cytoskeleton reorganization negative regulation of ATP citrate synthase activity uc008isp.1 uc008isp.2 uc008isp.3 
ENSMUST00000039160.3 Gpr176 ENSMUST00000039160.3 G protein-coupled receptor 176 (from RefSeq NM_201367.3) Agr9 ENSMUST00000039160.1 ENSMUST00000039160.2 GP176_MOUSE Gm1012 NM_201367 Q80UC4 Q80WT4 uc008lru.1 uc008lru.2 uc008lru.3 uc008lru.4 Orphan receptor involved in normal circadian rhythm behavior (PubMed:26882873). Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production (PubMed:26882873). Cell membrane ; Multi-pass membrane protein Expressed mainly in the brain, with prominent expression in the SCN (at protein level) (PubMed:26882873). Fluctuates in a circadian fashion, with highest level in night and lowest in the morning (at protein level). Deficient mice exhibit a significantly shorter circadian period. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway membrane integral component of membrane rhythmic process circadian behavior uc008lru.1 uc008lru.2 uc008lru.3 uc008lru.4 
ENSMUST00000039164.4 Lpar3 ENSMUST00000039164.4 lysophosphatidic acid receptor 3 (from RefSeq NM_022983.4) ENSMUST00000039164.1 ENSMUST00000039164.2 ENSMUST00000039164.3 Edg7 LPAR3_MOUSE Lpa3 NM_022983 Q9EQ31 uc008rra.1 uc008rra.2 uc008rra.3 uc008rra.4 Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. Cell membrane; Multi-pass membrane protein. Most abundantly expressed in testes, kidney, and lung, with moderate levels in small intestine, and low levels in heart, stomach, spleen, and adult and perinatal brain. Little or no expression in embryonic brain, liver, or thymus. Belongs to the G-protein coupled receptor 1 family. activation of MAPK activity G-protein alpha-subunit binding G-protein coupled receptor activity phospholipid binding plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane axon bleb assembly positive regulation of MAPK cascade positive regulation of collateral sprouting positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway positive regulation of calcium ion transport lysophosphatidic acid receptor activity uc008rra.1 uc008rra.2 uc008rra.3 uc008rra.4 
ENSMUST00000039165.15 Golga1 ENSMUST00000039165.15 golgin A1, transcript variant 3 (from RefSeq NR_110968.1) A3KGQ9 ENSMUST00000039165.1 ENSMUST00000039165.10 ENSMUST00000039165.11 ENSMUST00000039165.12 ENSMUST00000039165.13 ENSMUST00000039165.14 ENSMUST00000039165.2 ENSMUST00000039165.3 ENSMUST00000039165.4 ENSMUST00000039165.5 ENSMUST00000039165.6 ENSMUST00000039165.7 ENSMUST00000039165.8 ENSMUST00000039165.9 GOGA1_MOUSE NR_110968 Q80YB0 Q9CW79 uc008job.1 uc008job.2 uc008job.3 uc008job.4 Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Interacts with RAB6A (By similarity). Directly interacts with TBC1D23 (PubMed:29084197). Interacts with FAM91A1; this interaction may be mediated by TBC1D23 (Probable). Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Cytoplasmic vesicle, secretory vesicle, acrosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CW79-1; Sequence=Displayed; Name=2; IsoId=Q9CW79-2; Sequence=VSP_007726; Present in the acrosome of spermatids up to the late cap-stage, but not in mature spermatozoa. Extended rod-like protein with coiled-coil domains. acrosomal vesicle protein binding Golgi apparatus trans-Golgi network biological_process membrane cytoplasmic vesicle perinuclear region of cytoplasm uc008job.1 uc008job.2 uc008job.3 uc008job.4 
ENSMUST00000039171.9 Ccr3 ENSMUST00000039171.9 C-C motif chemokine receptor 3 (from RefSeq NM_009914.4) CCR3_MOUSE Cmkbr1l2 Cmkbr3 ENSMUST00000039171.1 ENSMUST00000039171.2 ENSMUST00000039171.3 ENSMUST00000039171.4 ENSMUST00000039171.5 ENSMUST00000039171.6 ENSMUST00000039171.7 ENSMUST00000039171.8 NM_009914 P51678 Q8K3M7 uc009sha.1 uc009sha.2 uc009sha.3 uc009sha.4 Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. Cell membrane; Multi-pass membrane protein Detected in skeletal muscle and in trace amounts in leukocytes. Deficient mice with induced pulmonary inflammation exhibit reduced trafficking of eosinophils from the blood into the lung parenchyma and increased numbers of intraepithelial mast cells in the trachea. Cholinergic stimulation resulted in airway hyperresponsiveness. Belongs to the G-protein coupled receptor 1 family. positive regulation of endothelial cell proliferation mast cell chemotaxis G-protein coupled receptor activity chemokine receptor activity protein binding extracellular space cytoplasm endosome plasma membrane chemotaxis inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration external side of plasma membrane membrane integral component of membrane C-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding angioblast cell migration positive regulation of angiogenesis eosinophil chemotaxis cell chemotaxis chemokine-mediated signaling pathway ERK1 and ERK2 cascade uc009sha.1 uc009sha.2 uc009sha.3 uc009sha.4 
ENSMUST00000039173.13 Relch ENSMUST00000039173.13 RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing, transcript variant 1 (from RefSeq NM_173187.4) 2310035C23Rik E9QM90 E9QM90_MOUSE ENSMUST00000039173.1 ENSMUST00000039173.10 ENSMUST00000039173.11 ENSMUST00000039173.12 ENSMUST00000039173.2 ENSMUST00000039173.3 ENSMUST00000039173.4 ENSMUST00000039173.5 ENSMUST00000039173.6 ENSMUST00000039173.7 ENSMUST00000039173.8 ENSMUST00000039173.9 NM_173187 Relch uc007cgk.1 uc007cgk.2 uc007cgk.3 uc007cgk.4 trans-Golgi network intracellular cholesterol transport recycling endosome uc007cgk.1 uc007cgk.2 uc007cgk.3 uc007cgk.4 
ENSMUST00000039177.12 Dpyd ENSMUST00000039177.12 dihydropyrimidine dehydrogenase (from RefSeq NM_170778.3) DPYD_MOUSE Dpyd ENSMUST00000039177.1 ENSMUST00000039177.10 ENSMUST00000039177.11 ENSMUST00000039177.2 ENSMUST00000039177.3 ENSMUST00000039177.4 ENSMUST00000039177.5 ENSMUST00000039177.6 ENSMUST00000039177.7 ENSMUST00000039177.8 ENSMUST00000039177.9 NM_170778 Q8CHR6 uc008rdh.1 uc008rdh.2 uc008rdh.3 Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. Reaction=5,6-dihydrouracil + NADP(+) = H(+) + NADPH + uracil; Xref=Rhea:RHEA:18093, ChEBI:CHEBI:15378, ChEBI:CHEBI:15901, ChEBI:CHEBI:17568, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.2; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18095; Evidence=; Reaction=5,6-dihydrothymine + NADP(+) = H(+) + NADPH + thymine; Xref=Rhea:RHEA:58284, ChEBI:CHEBI:15378, ChEBI:CHEBI:17821, ChEBI:CHEBI:27468, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.2; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:58286; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 2 FAD. ; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Note=Binds 2 FMN. ; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit. ; Inactivated by 5-iodouracil. Amino-acid biosynthesis; beta-alanine biosynthesis. Homodimer. Cytoplasm Belongs to the dihydropyrimidine dehydrogenase family. nucleotide binding uracil binding catalytic activity dihydrouracil dehydrogenase (NAD+) activity iron ion binding cytoplasm cytosol purine nucleobase catabolic process pyrimidine nucleobase catabolic process thymine catabolic process uracil catabolic process thymidine catabolic process response to nutrient circadian rhythm response to organic cyclic compound oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors dihydropyrimidine dehydrogenase (NADP+) activity beta-alanine biosynthetic process uracil metabolic process response to drug protein homodimerization activity metal ion binding NADP binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding oxidation-reduction process FAD binding uc008rdh.1 uc008rdh.2 uc008rdh.3 
ENSMUST00000039178.12 Tnn ENSMUST00000039178.12 tenascin N (from RefSeq NM_177839.3) B9EHR3 ENSMUST00000039178.1 ENSMUST00000039178.10 ENSMUST00000039178.11 ENSMUST00000039178.2 ENSMUST00000039178.3 ENSMUST00000039178.4 ENSMUST00000039178.5 ENSMUST00000039178.6 ENSMUST00000039178.7 ENSMUST00000039178.8 ENSMUST00000039178.9 NM_177839 Q70HX0 Q80Z71 TENN_MOUSE Tnn Tnw uc007dee.1 uc007dee.2 uc007dee.3 uc007dee.4 uc007dee.5 Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:14709716). Involved in neurite outgrowth and cell migration in hippocampal explants (PubMed:12812753). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (PubMed:17395156). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:15592496). Homohexamer. Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Comment=A number of isoforms are produced. ; Name=1; IsoId=Q80Z71-1; Sequence=Displayed; Name=2; IsoId=Q80Z71-2; Sequence=VSP_058850; Highest expression in kidney followed by spleen and brain. In brain, highest expression is found in hippocampus, cerebellum and olfactory bulb. Expressed in aortic valve, corneal limbus (PubMed:14709716). Expressed in ribs periosteum. During a fracture repair process, expression increases in cells of newly formed perichondrium/peristeum surrounding the cartalaginous callus (PubMed:14709716, PubMed:17395156). Hardly detectable at embryonic day (E) 14, then increases until postnatal day 17 and remains detectable in the adult (PubMed:12812753). Expressed as early as 11.5 dpc in the maxillary process until 16.5 dpc when is expressed in the newly formed mandible. At 14.5 dpc is detected in smooth muscle cells of the stomach and intestine and at 15.5, in the periosteum of the ribs. At 16.5 dpc the expression is restricted to mandible, palate and teeth (PubMed:14709716). During endochondral bone formation, first expressed at 13.5 dpc in the perichondrium. At E 16.5, detected in perichondrium and periosteum (PubMed:17395156). Belongs to the tenascin family. neuron migration osteoblast development integrin binding extracellular region cell-matrix adhesion axonogenesis cell surface extracellular matrix negative regulation of osteoblast proliferation identical protein binding neuron projection neuronal cell body negative regulation of osteoblast differentiation dendrite self-avoidance CA3 pyramidal cell dendrite negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation hippocampal mossy fiber expansion neuron projection extension negative regulation of neuron migration uc007dee.1 uc007dee.2 uc007dee.3 uc007dee.4 uc007dee.5 
ENSMUST00000039191.8 Tmem273 ENSMUST00000039191.8 transmembrane protein 273 (from RefSeq NM_001163616.1) E9PVZ2 E9PVZ2_MOUSE ENSMUST00000039191.1 ENSMUST00000039191.2 ENSMUST00000039191.3 ENSMUST00000039191.4 ENSMUST00000039191.5 ENSMUST00000039191.6 ENSMUST00000039191.7 NM_001163616 Tmem273 uc007szh.1 uc007szh.2 uc007szh.3 molecular_function cellular_component biological_process membrane integral component of membrane uc007szh.1 uc007szh.2 uc007szh.3 
ENSMUST00000039197.9 Slc44a3 ENSMUST00000039197.9 solute carrier family 44, member 3 (from RefSeq NM_145394.3) CTL3_MOUSE Ctl3 ENSMUST00000039197.1 ENSMUST00000039197.2 ENSMUST00000039197.3 ENSMUST00000039197.4 ENSMUST00000039197.5 ENSMUST00000039197.6 ENSMUST00000039197.7 ENSMUST00000039197.8 G5E8A3 NM_145394 Q921V7 uc008rdz.1 uc008rdz.2 uc008rdz.3 uc008rdz.4 Membrane ; Multi-pass membrane protein Belongs to the CTL (choline transporter-like) family. molecular_function cellular_component biological_process membrane integral component of membrane uc008rdz.1 uc008rdz.2 uc008rdz.3 uc008rdz.4 
ENSMUST00000039205.11 Galm ENSMUST00000039205.11 galactose mutarotase (from RefSeq NM_176963.4) ENSMUST00000039205.1 ENSMUST00000039205.10 ENSMUST00000039205.2 ENSMUST00000039205.3 ENSMUST00000039205.4 ENSMUST00000039205.5 ENSMUST00000039205.6 ENSMUST00000039205.7 ENSMUST00000039205.8 ENSMUST00000039205.9 GALM_MOUSE Galm NM_176963 Q8K157 uc008dqo.1 uc008dqo.2 uc008dqo.3 Mutarotase that catalyzes the interconversion of beta-D- galactose and alpha-D-galactose during galactose metabolism. Beta-D- galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1- phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose. Reaction=alpha-D-galactose = beta-D-galactose; Xref=Rhea:RHEA:28675, ChEBI:CHEBI:27667, ChEBI:CHEBI:28061; EC=5.1.3.3; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28677; Evidence=; Reaction=alpha-D-glucose = beta-D-glucose; Xref=Rhea:RHEA:10264, ChEBI:CHEBI:15903, ChEBI:CHEBI:17925; EC=5.1.3.3; Evidence=; Carbohydrate metabolism; hexose metabolism. Carbohydrate metabolism; galactose metabolism. Monomer. Cytoplasm Belongs to the aldose epimerase family. catalytic activity aldose 1-epimerase activity cytoplasm carbohydrate metabolic process glucose metabolic process galactose metabolic process isomerase activity hexose metabolic process carbohydrate binding galactose catabolic process via UDP-galactose protein homodimerization activity uc008dqo.1 uc008dqo.2 uc008dqo.3 
ENSMUST00000039213.15 Ibtk ENSMUST00000039213.15 inhibitor of Bruton agammaglobulinemia tyrosine kinase, transcript variant 2 (from RefSeq NM_175371.3) B9EHE9 ENSMUST00000039213.1 ENSMUST00000039213.10 ENSMUST00000039213.11 ENSMUST00000039213.12 ENSMUST00000039213.13 ENSMUST00000039213.14 ENSMUST00000039213.2 ENSMUST00000039213.3 ENSMUST00000039213.4 ENSMUST00000039213.5 ENSMUST00000039213.6 ENSMUST00000039213.7 ENSMUST00000039213.8 ENSMUST00000039213.9 IBTK_MOUSE Kiaa1417 NM_175371 Q3V3X0 Q6ZPR6 Q8BVL7 uc009qwx.1 uc009qwx.2 uc009qwx.3 Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity). Interacts with the PH domain of BTK. Cytoplasm Membrane ; Peripheral membrane protein Note=Translocates to the plasma membrane upon IgM stimulation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZPR6-1; Sequence=Displayed; Name=2; IsoId=Q6ZPR6-2; Sequence=VSP_023605; Sequence=BAC36779.1; Type=Frameshift; Evidence=; negative regulation of protein phosphorylation nucleoplasm cytoplasm membrane protein kinase binding protein tyrosine kinase inhibitor activity release of sequestered calcium ion into cytosol negative regulation of protein tyrosine kinase activity uc009qwx.1 uc009qwx.2 uc009qwx.3 
ENSMUST00000039229.8 Cdcp1 ENSMUST00000039229.8 CUB domain containing protein 1 (from RefSeq NM_133974.3) CDCP1_MOUSE ENSMUST00000039229.1 ENSMUST00000039229.2 ENSMUST00000039229.3 ENSMUST00000039229.4 ENSMUST00000039229.5 ENSMUST00000039229.6 ENSMUST00000039229.7 NM_133974 Q5U462 Q810J0 Q921M9 uc009sfz.1 uc009sfz.2 uc009sfz.3 May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. Interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. Also interacts SRC and PRKCG/protein kinase C gamma (By similarity). Cell membrane ; Single-pass membrane protein Note=Its shedding may lead to a soluble peptide. Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5 (By similarity). N-glycosylated. A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on the N-terminal side. Converted to p80 by plasmin, a trypsin-like protease (By similarity). cellular_component plasma membrane biological_process membrane integral component of membrane uc009sfz.1 uc009sfz.2 uc009sfz.3 
ENSMUST00000039234.10 Fbxl4 ENSMUST00000039234.10 F-box and leucine-rich repeat protein 4, transcript variant 1 (from RefSeq NM_172988.5) ENSMUST00000039234.1 ENSMUST00000039234.2 ENSMUST00000039234.3 ENSMUST00000039234.4 ENSMUST00000039234.5 ENSMUST00000039234.6 ENSMUST00000039234.7 ENSMUST00000039234.8 ENSMUST00000039234.9 FBXL4_MOUSE NM_172988 Q8BH70 uc008sdo.1 uc008sdo.2 uc008sdo.3 Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Cytoplasm Nucleus Mitochondrion nucleus cytoplasm mitochondrion mitochondrial intermembrane space ubiquitin-dependent protein catabolic process protein ubiquitination nuclear speck SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein transferase activity uc008sdo.1 uc008sdo.2 uc008sdo.3 
ENSMUST00000039271.7 2610008E11Rik ENSMUST00000039271.7 RIKEN cDNA 2610008E11 gene, transcript variant 3 (from RefSeq NM_001359717.1) 2610008E11Rik ENSMUST00000039271.1 ENSMUST00000039271.2 ENSMUST00000039271.3 ENSMUST00000039271.4 ENSMUST00000039271.5 ENSMUST00000039271.6 G3X964 G3X964_MOUSE NM_001359717 uc007fyo.1 uc007fyo.2 uc007fyo.3 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc007fyo.1 uc007fyo.2 uc007fyo.3 
ENSMUST00000039280.9 Scaf4 ENSMUST00000039280.9 SR-related CTD-associated factor 4, transcript variant 1 (from RefSeq NM_178923.5) A0A338P6Z6 ENSMUST00000039280.1 ENSMUST00000039280.2 ENSMUST00000039280.3 ENSMUST00000039280.4 ENSMUST00000039280.5 ENSMUST00000039280.6 ENSMUST00000039280.7 ENSMUST00000039280.8 Kiaa1172 NM_178923 Q69ZP8 Q6PFF0 Q7TSH6 Q8R1B3 SCAF4_MOUSE Scaf4 Srsf15 uc007zwb.1 uc007zwb.2 uc007zwb.3 uc007zwb.4 uc007zwb.5 Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough. Interacts with POLR2A; via C-terminal heptapeptide repeat domain (CTD) phosphorylated at 'Ser-2' and 'Ser-5'. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7TSH6-1; Sequence=Displayed; Name=2; IsoId=Q7TSH6-2; Sequence=VSP_060218; Name=3; IsoId=Q7TSH6-3; Sequence=VSP_060219, VSP_060220; Sequence=AAH24860.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAD32398.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleic acid binding RNA binding nucleus nucleoplasm mRNA processing protein C-terminus binding RNA polymerase II C-terminal domain phosphoserine binding negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled uc007zwb.1 uc007zwb.2 uc007zwb.3 uc007zwb.4 uc007zwb.5 
ENSMUST00000039286.5 Atg5 ENSMUST00000039286.5 autophagy related 5, transcript variant 1 (from RefSeq NM_053069.6) ATG5_MOUSE Apg5l ENSMUST00000039286.1 ENSMUST00000039286.2 ENSMUST00000039286.3 ENSMUST00000039286.4 NM_053069 Q99J83 uc007ezt.1 uc007ezt.2 uc007ezt.3 uc007ezt.4 The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD (By similarity). (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection. Forms a conjugate with ATG12 (PubMed:11266458, PubMed:12890687, PubMed:12665549, PubMed:18768753, PubMed:19417210). The ATG5-ATG12 conjugate forms a complex with several units of ATG16L1 (PubMed:12665549). Forms an 800-kDa complex composed of ATG12-ATG5 and ATG16L2 (PubMed:22082872). Interacts with TECPR1; the interaction is direct and does not take place when ATG16L1 is associated with the ATG5-ATG12 conjugate (By similarity). Interacts with DHX58/RIG-1, IFIH1/MDA5 and MAVS/IPS-1 in monomeric form as well as in ATG12-ATG5 conjugate form. The interaction with MAVS is further enhanced upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Interacts with ATG3 (By similarity). Interacts with ATG7 and ATG10 (PubMed:12482611). Interacts with FADD (By similarity). Interacts with Bassoon/BSN; this interaction is important for the regulation of presynaptic autophagy. Interacts with ATG16L2 (PubMed:22082872). Q99J83; Q9CQY1: Atg12; NbExp=4; IntAct=EBI-2911848, EBI-2911788; Q99J83; Q8C0J2: Atg16l1; NbExp=4; IntAct=EBI-2911848, EBI-769195; Cytoplasm Preautophagosomal structure membrane ; Peripheral membrane protein Note=The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. Ubiquitous. Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane. Acetylated by EP300. Belongs to the ATG5 family. autophagosome assembly mitophagy blood vessel remodeling immune system process regulation of cytokine secretion involved in immune response protein binding cytoplasm autophagosome cytosol axoneme C-terminal protein lipidation autophagy apoptotic process cellular response to nitrogen starvation cellular response to starvation response to fungus membrane macroautophagy cellular homeostasis antigen processing and presentation of endogenous antigen negative regulation of protein ubiquitination pre-autophagosomal structure membrane Atg12-Atg5-Atg16 complex aggrephagy negative stranded viral RNA replication vasodilation response to drug negative regulation of apoptotic process post-translational protein modification ER-mitochondrion membrane contact site negative thymic T cell selection otolith development negative regulation of phagocytosis regulation of release of sequestered calcium ion into cytosol ventricular cardiac muscle cell development heart contraction negative regulation of cell death protein lipidation involved in autophagosome assembly positive regulation of mucus secretion cellular response to nitrosative stress autophagy of host cells involved in interaction with symbiont regulation of cilium assembly regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process negative regulation of histone H4-K16 acetylation Atg8 ligase activity uc007ezt.1 uc007ezt.2 uc007ezt.3 uc007ezt.4 
ENSMUST00000039303.7 Npy1r ENSMUST00000039303.7 neuropeptide Y receptor Y1, transcript variant 1 (from RefSeq NM_010934.4) ENSMUST00000039303.1 ENSMUST00000039303.2 ENSMUST00000039303.3 ENSMUST00000039303.4 ENSMUST00000039303.5 ENSMUST00000039303.6 NM_010934 Npy1r Q3V1K5 Q3V1K5_MOUSE uc009lvt.1 uc009lvt.2 uc009lvt.3 uc009lvt.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. outflow tract morphogenesis G-protein coupled receptor activity neuropeptide Y receptor activity signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway membrane integral component of membrane uc009lvt.1 uc009lvt.2 uc009lvt.3 uc009lvt.4 
ENSMUST00000039305.6 Slc36a2 ENSMUST00000039305.6 solute carrier family 36 (proton/amino acid symporter), member 2 (from RefSeq NM_153170.3) ENSMUST00000039305.1 ENSMUST00000039305.2 ENSMUST00000039305.3 ENSMUST00000039305.4 ENSMUST00000039305.5 NM_153170 Pat2 Q8BHK3 Q8BUB0 Q8JZP1 S36A2_MOUSE Slc36a2 Tramd1 uc007iyz.1 uc007iyz.2 uc007iyz.3 uc007iyz.4 Electrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. Extension of the backbone length, as in beta-alanine and 4-aminobutanoate or methylation of the amino group, as in sarcosine and N,N- dimethylglycine, are also tolerated but decrease transport efficiency. A free carboxyl group is preferred. Reaction=glycine(in) + H(+)(in) = glycine(out) + H(+)(out); Xref=Rhea:RHEA:28899, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305; Evidence= Reaction=H(+)(in) + L-alanine(in) = H(+)(out) + L-alanine(out); Xref=Rhea:RHEA:29443, ChEBI:CHEBI:15378, ChEBI:CHEBI:57972; Evidence=; Reaction=D-alanine(in) + H(+)(in) = D-alanine(out) + H(+)(out); Xref=Rhea:RHEA:28903, ChEBI:CHEBI:15378, ChEBI:CHEBI:57416; Evidence=; Reaction=H(+)(out) + L-proline(out) = H(+)(in) + L-proline(in); Xref=Rhea:RHEA:28963, ChEBI:CHEBI:15378, ChEBI:CHEBI:60039; Evidence= Reaction=D-proline(out) + H(+)(out) = D-proline(in) + H(+)(in); Xref=Rhea:RHEA:70643, ChEBI:CHEBI:15378, ChEBI:CHEBI:57726; Evidence=; Reaction=4-hydroxy-L-proline(in) + H(+)(in) = 4-hydroxy-L-proline(out) + H(+)(out); Xref=Rhea:RHEA:70663, ChEBI:CHEBI:15378, ChEBI:CHEBI:58419; Evidence=; Reaction=H(+)(in) + L-serine(in) = H(+)(out) + L-serine(out); Xref=Rhea:RHEA:28887, ChEBI:CHEBI:15378, ChEBI:CHEBI:33384; Evidence=; Reaction=D-serine(out) + H(+)(out) = D-serine(in) + H(+)(in); Xref=Rhea:RHEA:70647, ChEBI:CHEBI:15378, ChEBI:CHEBI:35247; Evidence=; Reaction=beta-alanine(in) + H(+)(in) = beta-alanine(out) + H(+)(out); Xref=Rhea:RHEA:29459, ChEBI:CHEBI:15378, ChEBI:CHEBI:57966; Evidence=; Reaction=4-aminobutanoate(in) + H(+)(in) = 4-aminobutanoate(out) + H(+)(out); Xref=Rhea:RHEA:28915, ChEBI:CHEBI:15378, ChEBI:CHEBI:59888; Evidence= Reaction=H(+)(in) + sarcosine(in) = H(+)(out) + sarcosine(out); Xref=Rhea:RHEA:70655, ChEBI:CHEBI:15378, ChEBI:CHEBI:57433; Evidence=; Reaction=H(+)(in) + N,N-dimethylglycine(in) = H(+)(out) + N,N- dimethylglycine(out); Xref=Rhea:RHEA:70659, ChEBI:CHEBI:15378, ChEBI:CHEBI:58251; Evidence=; Kinetic parameters: KM=0.59 mM for glycine ; KM=0.26 mM for L-alanine ; KM=0.12 mM for L-proline ; KM=43 mM for L-serine ; KM=6.5 mM for D-alanine ; KM=30.9 mM for 4-aminobutanoate/GABA ; Cell membrane ulti-pass membrane protein Endoplasmic reticulum membrane Recycling endosome membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BHK3-1; Sequence=Displayed; Name=2; IsoId=Q8BHK3-2; Sequence=VSP_032374, VSP_032375; Expressed in spinal cord, brain, testis, lung, heart, colon, spleen, kidney and muscle. Found in neuronal cell bodies in the anterior horn, in spinal cord brain stem, cerebellum, hippocampus, hypothalamus, rhinencephalon, cerebral cortex, and olfactory bulb in the brain. Also expressed in bone and fat tissues. Belongs to the amino acid/polyamine transporter 2 family. amino acid transmembrane transport hydrogen:amino acid symporter activity cytoplasm plasma membrane regulation of proton transport hydrogen ion transmembrane transporter activity amino acid transmembrane transporter activity L-alanine transmembrane transporter activity glycine transmembrane transporter activity L-proline transmembrane transporter activity L-alanine transport glycine transport proline transport tyrosine transport membrane integral component of membrane amino acid export proline transmembrane transport regulation of proline transport positive regulation of glycine import hydrogen ion transmembrane transport L-tyrosine transmembrane transporter activity uc007iyz.1 uc007iyz.2 uc007iyz.3 uc007iyz.4 
ENSMUST00000039309.12 Sectm1b ENSMUST00000039309.12 secreted and transmembrane 1B, transcript variant 1 (from RefSeq NM_026907.4) ENSMUST00000039309.1 ENSMUST00000039309.10 ENSMUST00000039309.11 ENSMUST00000039309.2 ENSMUST00000039309.3 ENSMUST00000039309.4 ENSMUST00000039309.5 ENSMUST00000039309.6 ENSMUST00000039309.7 ENSMUST00000039309.8 ENSMUST00000039309.9 NM_026907 Q9D966 Q9D966_MOUSE Sectm1 Sectm1b uc007mvd.1 uc007mvd.2 uc007mvd.3 cytokine activity immune response signal transduction membrane integral component of membrane uc007mvd.1 uc007mvd.2 uc007mvd.3 
ENSMUST00000039323.8 AA986860 ENSMUST00000039323.8 expressed sequence AA986860, transcript variant 1 (from RefSeq NM_177604.4) A2VDH0 ENSMUST00000039323.1 ENSMUST00000039323.2 ENSMUST00000039323.3 ENSMUST00000039323.4 ENSMUST00000039323.5 ENSMUST00000039323.6 ENSMUST00000039323.7 NM_177604 Q4FZK7 Q8BHU5 Q8BI29 SARG_MOUSE Sarg uc007cmi.1 uc007cmi.2 uc007cmi.3 Putative androgen-specific receptor. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BI29-1; Sequence=Displayed; Name=2; IsoId=Q8BI29-2; Sequence=VSP_031229; Belongs to the SARG family. molecular_function cytoplasm cytosol plasma membrane biological_process uc007cmi.1 uc007cmi.2 uc007cmi.3 
ENSMUST00000039327.11 Dagla ENSMUST00000039327.11 diacylglycerol lipase, alpha (from RefSeq NM_198114.2) A8WFL4 DGLA_MOUSE ENSMUST00000039327.1 ENSMUST00000039327.10 ENSMUST00000039327.2 ENSMUST00000039327.3 ENSMUST00000039327.4 ENSMUST00000039327.5 ENSMUST00000039327.6 ENSMUST00000039327.7 ENSMUST00000039327.8 ENSMUST00000039327.9 Kiaa0659 NM_198114 Nsddr Q6WQJ1 Q6ZQ76 uc008gpm.1 uc008gpm.2 Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid (eCB), 2-arachidonoylglycerol (2-AG) (PubMed:17584991, PubMed:23103940). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG. Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:17584991). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS) (PubMed:20159446, PubMed:20147530, PubMed:25466252, PubMed:26668358, PubMed:26779719). Controls the activity of 2-AG as a retrograde messenger at neuronal synapses (PubMed:20159446, PubMed:20147530, PubMed:26668358). Supports axonal growth during development and adult neurogenesis (PubMed:20147530). Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors (PubMed:25466252). Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (PubMed:26779719). Reaction=a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:33275, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17389, ChEBI:CHEBI:17815, ChEBI:CHEBI:28868; EC=3.1.1.116; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33276; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate; Xref=Rhea:RHEA:38507, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:52392, ChEBI:CHEBI:75728; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38508; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)- octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38511, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52333, ChEBI:CHEBI:73990; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38512; Evidence=; Reaction=1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn- glycerol + H2O = (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38515, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52392, ChEBI:CHEBI:75449; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38516; Evidence=; Reaction=1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = (9Z)- octadecenoate + 2-octadecanoylglycerol + H(+); Xref=Rhea:RHEA:38519, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75448, ChEBI:CHEBI:75456; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38520; Evidence=; Reaction=1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+); Xref=Rhea:RHEA:38523, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75450, ChEBI:CHEBI:75457; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38524; Evidence=; Reaction=1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn- glycerol + H2O = (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)- eicosatetraenylglycerol + H(+); Xref=Rhea:RHEA:38527, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75913, ChEBI:CHEBI:75914; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38528; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Inhibited by 1,2,3-triazole urea covalent inhibitor KT172, DH376 and DO34 (PubMed:23103940, PubMed:26668358). Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267. Diacylglycerol lipase activity is inhibited by the phosphorylation of Ser-784 and Ser-810 by CAMK2A (By similarity). Interacts (via C-terminal) with CAMK2A; leading to the phosphorylation and inhibition of DAGLA enzymatic activity (PubMed:23502535). Interacts (via PPXXF motif) with HOMER1 and HOMER2; this interaction is required for DAGLA membrane localization (PubMed:17584991). Cell membrane ; Multi-pass membrane protein Cell projection, dendritic spine membrane ; Multi-pass membrane protein Postsynaptic density membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Note=Cycles between the cell surface and an intracellular endosomal compartment. Internalized by early endosomes via a clathrin-independent pathway before transport back to the postsynaptic membrane surface in a PKC-dependent manner. Highly expressed by principal cells in the hippocampus. In embryonic brains, it is present in axonal tracts, while in adults it localizes to dendritic fields, correlating with the developmental change in requirement for 2-AG synthesis from the pre- to the postsynaptic compartment. Concentrated in heads of dendritic spines throughout the hippocampal formation. Highly compartmentalized into a wide perisynaptic annulus around the postsynaptic density of axospinous contacts but not intrasynaptically (at protein level). Phosphorylated at Ser-784 and Ser-810 by CAMK2A; phosphorylation by CAMK2A inhibits diacylglycerol lipase activity. Deficient mice are viable, fertile and display normal physiological behaviors (PubMed:20159446, PubMed:20147530). Deficient mice show 80-90% reductions in brain 2-AG as well as the downstream product arachidonic acid (AA), in particular in neurons and astrocytes (PubMed:20159446, PubMed:20147530, PubMed:26779719, PubMed:25466252). The endocannabinoid-mediated retrograde synaptic suppression of neurotransmitter release is absent in the cerebellum, hippocampus, and striatum of knockout mice (PubMed:20159446, PubMed:20147530). In addition, reduction in adult neurogenesis is observed in deficient mice in both the hippocampus and the subventricular zone (PubMed:20147530). DAGLA deletion increases anxiety-like and depressive behaviors (PubMed:25466252). Reduction in LPS-stimulated neuroinflammation is also observed in knockout mice (PubMed:26779719). Belongs to the AB hydrolase superfamily. Lipase family. plasma membrane lipid metabolic process G-protein coupled glutamate receptor signaling pathway neuroblast proliferation membrane integral component of membrane lipid catabolic process hydrolase activity arachidonic acid metabolic process neurogenesis neurotransmitter biosynthetic process varicosity postsynaptic membrane diacylglycerol catabolic process metal ion binding endocannabinoid signaling pathway retrograde trans-synaptic signaling by endocannabinoid integral component of postsynaptic membrane uc008gpm.1 uc008gpm.2 
ENSMUST00000039331.9 Igsf21 ENSMUST00000039331.9 immunoglobulin superfamily, member 21 (from RefSeq NM_198610.2) ENSMUST00000039331.1 ENSMUST00000039331.2 ENSMUST00000039331.3 ENSMUST00000039331.4 ENSMUST00000039331.5 ENSMUST00000039331.6 ENSMUST00000039331.7 ENSMUST00000039331.8 IGS21_MOUSE NM_198610 Q7TNR6 uc008vmu.1 uc008vmu.2 uc008vmu.3 uc008vmu.4 Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2. Interacts (Ig-like 1 domain) with NRXN2 (via Laminin G-like 1 domain) in a trans-interaction manner. Postsynaptic cell membrane ; Lipid-anchor, GPI-anchor Expressed in brain (at protein levels) (PubMed:28864826). Highly expressed in the pyramidal cell layer of the dorsal and ventral hippocampal CA1 and CA3 regions, layers 5 and 6 of the cortex, the thalamus and the pons and weakly expressed in the cerebellum (PubMed:28864826). Expressed in neurons but not in glia (PubMed:28864826). Expressed in the brain at both embryonic and postnatal stages including the adult stage. The period of highest expression of the long isoform is at around two postnatal weeks, coinciding with the peak period of synaptogenesis. Ig-like 1 domain is indispensable for synaptogenic activity whereas Ig-like 2 domain is secondarily responsible for the activity. Mutants grow normally. They show an impaired sensorimotor gating with no effect on motor activity and coordination. protein binding plasma membrane cell-cell adherens junction homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules membrane cell junction anchored component of membrane anchored component of external side of plasma membrane signaling receptor activity presynaptic membrane protein homodimerization activity synapse postsynaptic membrane cell adhesion molecule binding synapse maturation inhibitory synapse uc008vmu.1 uc008vmu.2 uc008vmu.3 uc008vmu.4 
ENSMUST00000039333.10 Pdpr ENSMUST00000039333.10 pyruvate dehydrogenase phosphatase regulatory subunit (from RefSeq NM_198308.1) ENSMUST00000039333.1 ENSMUST00000039333.2 ENSMUST00000039333.3 ENSMUST00000039333.4 ENSMUST00000039333.5 ENSMUST00000039333.6 ENSMUST00000039333.7 ENSMUST00000039333.8 ENSMUST00000039333.9 Kiaa1990 NM_198308 PDPR_MOUSE Q6ZPF5 Q7TSQ8 uc009nlw.1 uc009nlw.2 uc009nlw.3 Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine. Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit. Mitochondrion matrix Belongs to the GcvT family. Sequence=BAC98282.1; Type=Erroneous initiation; Evidence=; cytoplasm mitochondrion mitochondrial matrix oxidoreductase activity oxidation-reduction process uc009nlw.1 uc009nlw.2 uc009nlw.3 
ENSMUST00000039349.8 Dync2i1 ENSMUST00000039349.8 dynein 2 intermediate chain 1 (from RefSeq NM_146039.3) DC2I1_MOUSE ENSMUST00000039349.1 ENSMUST00000039349.2 ENSMUST00000039349.3 ENSMUST00000039349.4 ENSMUST00000039349.5 ENSMUST00000039349.6 ENSMUST00000039349.7 NM_146039 Q3UNM4 Q8C761 Wdr60 uc007phj.1 uc007phj.2 uc007phj.3 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella. Requires also to maintain a functional transition zone. Intermediate chain of the cytoplasmic dynein complex 2, a multisubunit complex, composed at least of eleven different proteins. The cytoplasmic dynein 2 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs). Among them, a heavy chain (DYNC2H1), two intermediate chains (DYNC2I2 and DYNC2I1), a light intermediate chain (DYNC2LI1), and a light chain (DYNLT2B) are unique to the cytoplasmic dynein complex 2, but a subset of the light chains are also shared by dynein-1 and dynein-2 complexes. Interacts with DYNC2I2; their C-terminal domains each bind a copy of the heavy chain, and their extended N-terminal regions are held together by an array of light chain dimers. Interacts with DYNLT2B. Interacts (via the N-terminal half) with DYNLT2B-DYNLT1 dimer or with DYNLT2B-DYNLT3 dimer; this interaction is crucial for retrograde trafficking of ciliary proteins. Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Located at the base of the primary cilium in serum-starved fibroblasts. Belongs to the dynein light intermediate chain family. pericentriolar material spindle pole centrosome cytoplasmic dynein complex cilium microtubule-based movement cell projection organization interphase microtubule organizing center cell projection dynein light chain binding dynein heavy chain binding embryonic skeletal system morphogenesis cilium assembly ciliary base positive regulation of ATP-dependent microtubule motor activity, plus-end-directed ATP-dependent microtubule motor activity, plus-end-directed uc007phj.1 uc007phj.2 uc007phj.3 
ENSMUST00000039366.11 Kcnh8 ENSMUST00000039366.11 potassium voltage-gated channel, subfamily H (eag-related), member 8 (from RefSeq NM_001031811.2) ENSMUST00000039366.1 ENSMUST00000039366.10 ENSMUST00000039366.2 ENSMUST00000039366.3 ENSMUST00000039366.4 ENSMUST00000039366.5 ENSMUST00000039366.6 ENSMUST00000039366.7 ENSMUST00000039366.8 ENSMUST00000039366.9 F6TUN6 F6TUN6_MOUSE Kcnh8 NM_001031811 uc029tiu.1 uc029tiu.2 uc029tiu.3 The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Membrane ; Multi- pass membrane protein ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity plasma membrane ion transport potassium ion transport membrane integral component of membrane regulation of ion transmembrane transport transmembrane transport potassium ion transmembrane transport uc029tiu.1 uc029tiu.2 uc029tiu.3 
ENSMUST00000039370.14 Cacna2d1 ENSMUST00000039370.14 calcium channel, voltage-dependent, alpha2/delta subunit 1, transcript variant a (from RefSeq NM_001110843.1) CA2D1_MOUSE Cacna2 ENSMUST00000039370.1 ENSMUST00000039370.10 ENSMUST00000039370.11 ENSMUST00000039370.12 ENSMUST00000039370.13 ENSMUST00000039370.2 ENSMUST00000039370.3 ENSMUST00000039370.4 ENSMUST00000039370.5 ENSMUST00000039370.6 ENSMUST00000039370.7 ENSMUST00000039370.8 ENSMUST00000039370.9 NM_001110843 O08532 O08533 O08534 O08535 O08536 uc008wna.1 uc008wna.2 uc008wna.3 uc008wna.4 This gene encodes a regulatory component of the voltage-dependent calcium channel complex. The product of this gene is a proprotein that is proteolytically processed into alpha-2 and delta subunits, which are linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (By similarity). Plays an important role in excitation-contraction coupling (By similarity). Dimer formed of alpha-2-1 and delta-1 chains; disulfide- linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity). O08532; P04925: Prnp; NbExp=3; IntAct=EBI-770939, EBI-768613; Membrane ; Single-pass type I membrane protein Cell membrane Event=Alternative splicing; Named isoforms=5; Name=2A; IsoId=O08532-1; Sequence=Displayed; Name=2B; IsoId=O08532-2; Sequence=VSP_050444; Name=2C; IsoId=O08532-3; Sequence=VSP_050445; Name=2D; IsoId=O08532-4; Sequence=VSP_050445, VSP_050446; Name=2E; IsoId=O08532-5; Sequence=VSP_050444, VSP_050446; Isoform 2A is expressed in skeletal muscle and aorta. Isoform 2B is expressed in brain. Isoform 2C is expressed in heart. Isoform 2D is expressed in heart and smooth muscle. Isoform 2E is expressed in smooth muscle. All five isoforms are expressed in the cardiovascular system. The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked. Binds gabapentin, an antiepileptic drug. Belongs to the calcium channel subunit alpha-2/delta family. voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity protein binding voltage-gated calcium channel complex ion transport calcium ion transport membrane integral component of membrane sarcoplasmic reticulum T-tubule regulation of ion transmembrane transport metal ion binding regulation of calcium ion transport regulation of ventricular cardiac muscle cell membrane repolarization calcium ion transport into cytosol calcium ion transmembrane transport via high voltage-gated calcium channel calcium ion transmembrane transport cardiac muscle cell action potential involved in contraction membrane depolarization during bundle of His cell action potential voltage-gated calcium channel activity involved in bundle of His cell action potential regulation of heart rate by cardiac conduction regulation of membrane repolarization during action potential glutamatergic synapse anchored component of postsynaptic membrane anchored component of presynaptic active zone membrane positive regulation of voltage-gated calcium channel activity positive regulation of high voltage-gated calcium channel activity regulation of calcium ion transmembrane transport via high voltage-gated calcium channel cellular response to beta-amyloid L-type voltage-gated calcium channel complex uc008wna.1 uc008wna.2 uc008wna.3 uc008wna.4 
ENSMUST00000039374.9 Ints6l ENSMUST00000039374.9 integrator complex subunit 6 like, transcript variant 3 (from RefSeq NM_172779.5) Ddx26b ENSMUST00000039374.1 ENSMUST00000039374.2 ENSMUST00000039374.3 ENSMUST00000039374.4 ENSMUST00000039374.5 ENSMUST00000039374.6 ENSMUST00000039374.7 ENSMUST00000039374.8 INT6L_MOUSE NM_172779 Q8BND4 uc009tgg.1 uc009tgg.2 uc009tgg.3 uc009tgg.4 molecular_function integrator complex snRNA 3'-end processing uc009tgg.1 uc009tgg.2 uc009tgg.3 uc009tgg.4 
ENSMUST00000039380.9 Gjb6 ENSMUST00000039380.9 gap junction protein, beta 6, transcript variant 6 (from RefSeq NM_001424450.1) Cxnf ENSMUST00000039380.1 ENSMUST00000039380.2 ENSMUST00000039380.3 ENSMUST00000039380.4 ENSMUST00000039380.5 ENSMUST00000039380.6 ENSMUST00000039380.7 ENSMUST00000039380.8 Gjb6 NM_001424450 Q3URC5 Q3URC5_MOUSE uc007ucy.1 uc007ucy.2 uc007ucy.3 uc007ucy.4 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Cell junction, gap junction Cell membrane ; Multi- pass membrane protein mbrane ; Multi-pass membrane protein Belongs to the connexin family. gap junction channel activity cytosol actin filament plasma membrane gap junction connexin complex apoptotic process cell communication aging microtubule binding negative regulation of cell proliferation cell communication by electrical coupling membrane integral component of membrane gap junction assembly apical plasma membrane cell junction response to lipopolysaccharide beta-tubulin binding inner ear development actin filament binding response to electrical stimulus transmembrane transport cellular response to glucose stimulus gap junction channel activity involved in cell communication by electrical coupling gap junction-mediated intercellular transport uc007ucy.1 uc007ucy.2 uc007ucy.3 uc007ucy.4 
ENSMUST00000039388.3 Arl4d ENSMUST00000039388.3 ADP-ribosylation factor-like 4D (from RefSeq NM_025404.3) ARL4D_MOUSE Arf4l Arl5 ENSMUST00000039388.1 ENSMUST00000039388.2 NM_025404 Q99PE9 Q9CQB1 uc007lpq.1 uc007lpq.2 uc007lpq.3 Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity). Interacts with CYTH2; the interaction is direct and ARL4D GTP- dependent. Does not interact with ARL4D (By similarity). Nucleus, nucleolus Cell membrane Nucleus Cytoplasm Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTP binding nucleus nucleolus cytoplasm plasma membrane intracellular protein transport membrane vesicle-mediated transport uc007lpq.1 uc007lpq.2 uc007lpq.3 
ENSMUST00000039390.6 Ky ENSMUST00000039390.6 kyphoscoliosis peptidase (from RefSeq NM_024291.4) ENSMUST00000039390.1 ENSMUST00000039390.2 ENSMUST00000039390.3 ENSMUST00000039390.4 ENSMUST00000039390.5 F8VQF8 F8VQF8_MOUSE Ky NM_024291 uc009rfp.1 uc009rfp.2 uc009rfp.3 uc009rfp.1 uc009rfp.2 uc009rfp.3 
ENSMUST00000039408.3 Pkp2 ENSMUST00000039408.3 plakophilin 2 (from RefSeq NM_026163.2) ENSMUST00000039408.1 ENSMUST00000039408.2 NM_026163 PKP2_MOUSE Pkp2 Q3TIY5 Q9CQ73 uc007yid.1 uc007yid.2 uc007yid.3 Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (By similarity). Required to maintain gingival epithelial barrier function (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes (By similarity). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (PubMed:15479741). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (PubMed:15479741). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). May play a role in junctional plaques (By similarity). Interacts with DSC2 (By similarity). Interacts with JUP (By similarity). Interacts with KRT5/CK5, KRT8/CK8, KRT14/CK14, KRT18/CK18 and VIM (By similarity). Interacts (via N-terminus) with MARK3/C-TAK1 (By similarity). Interacts with DSP (By similarity). Interacts with DSG1, DSG2 and DSG3 (By similarity). Interacts (via N-terminus) with CTNNB1 (By similarity). Interacts with CDH1 (By similarity). Interacts with the RNA polymerase III (Pol III) complex proteins POLR3A/RPC155, POLR3F/RPC39 and POLR3C/RPC82 (By similarity). Interacts with CTNNA3 (By similarity). Interacts (via N-terminus) with SCN5A/Nav1.5 (By similarity). Nucleus Cell junction, desmosome Cell junction Cytoplasm Note=Colocalizes with CTNNA3 and SCN5A/Nav1.5 at intercalated disks in the heart. Expressed in heart (at protein level). Expressed in cardiomyocytes of the atrium and ventricle of the heart in embryos at 10.75 and 13.75 dpc. Knockout mice die during embryogenesis (PubMed:15479741). Embryos show accumulation of blood in the pericardial and peritoneal cavities, and absence in the head, dorsal trunk and yolk sac at 10.75 dpc followed by a significant decrease in viable embryos at 11.5 dpc (PubMed:15479741). Embryonic heart formation is abnormal showing reduced trabeculation in the heart ventricles and thinning of the atria walls (PubMed:15479741). Loss of DSP and DSG2 localization at cell-cell junctions in cardiomyocytes, DSP localizes to granular aggregates in the cytoplasm which are surrounded by disordered swirls of intermediate filaments (PubMed:15479741). Loss of fascia adherens-like and desmosome-like cell junctions at the intercalated disks (PubMed:15479741). Belongs to the beta-catenin family. desmosome assembly protein kinase C binding protein binding nucleus nucleoplasm cytoplasm intermediate filament plasma membrane cell-cell junction adherens junction cell-cell adherens junction cell-cell junction assembly heart development negative regulation of cell proliferation intercalated disc gap junction assembly intermediate filament binding cell junction desmosome negative regulation of cell migration adherens junction maintenance intermediate filament bundle assembly alpha-catenin binding cadherin binding maintenance of animal organ identity ventricular cardiac muscle tissue morphogenesis lipid homeostasis binding, bridging protein localization to plasma membrane cardiac muscle cell action potential cardiac muscle cell action potential involved in contraction ventricular cardiac muscle cell action potential cell-cell signaling involved in cardiac conduction bundle of His cell-Purkinje myocyte adhesion involved in cell communication regulation of heart rate by cardiac conduction cell-cell adhesion regulation of ventricular cardiac muscle cell action potential regulation of bicellular tight junction assembly uc007yid.1 uc007yid.2 uc007yid.3 
ENSMUST00000039412.15 Mcph1 ENSMUST00000039412.15 microcephaly, primary autosomal recessive 1, transcript variant 3 (from RefSeq NM_173189.4) ENSMUST00000039412.1 ENSMUST00000039412.10 ENSMUST00000039412.11 ENSMUST00000039412.12 ENSMUST00000039412.13 ENSMUST00000039412.14 ENSMUST00000039412.2 ENSMUST00000039412.3 ENSMUST00000039412.4 ENSMUST00000039412.5 ENSMUST00000039412.6 ENSMUST00000039412.7 ENSMUST00000039412.8 ENSMUST00000039412.9 MCPH1_MOUSE Mcph1 NM_173189 Q7TT79 Q8BNI9 Q8C9I7 uc009kzt.1 uc009kzt.2 uc009kzt.3 uc009kzt.4 Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity). Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome High levels of expression are found in the developing forebrain and, in particular, in the walls of the lateral ventricles. BRCT domain 1 is required to prevent abnormal chromosome condensation. It binds directly to the SWI-SNF chromatin remodeling complex (By similarity). BRCT domains 2 and 3 recognize phosphoserine/phosphothreonine marks on proteins with high selectivity, and mediate interaction with phosphorylated CDC27. They also mediate the dual recognition of phosphoserine and phosphotyrosine in the C-terminal tail of histone H2AX (By similarity). Sequence=BAC31136.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter establishment of mitotic spindle orientation cytoplasm microtubule organizing center cytoskeleton regulation of gene expression cerebral cortex development identical protein binding regulation of kinase activity regulation of centrosome cycle regulation of inflammatory response bone development regulation of chromosome condensation protein localization to centrosome mitotic cell cycle arrest neuronal stem cell population maintenance uc009kzt.1 uc009kzt.2 uc009kzt.3 uc009kzt.4 
ENSMUST00000039419.12 Igsf10 ENSMUST00000039419.12 immunoglobulin superfamily, member 10 (from RefSeq NM_001162884.1) ENSMUST00000039419.1 ENSMUST00000039419.10 ENSMUST00000039419.11 ENSMUST00000039419.2 ENSMUST00000039419.3 ENSMUST00000039419.4 ENSMUST00000039419.5 ENSMUST00000039419.6 ENSMUST00000039419.7 ENSMUST00000039419.8 ENSMUST00000039419.9 IGS10_MOUSE NM_001162884 Q3UPM4 Q3V1M1 uc008piu.1 uc008piu.2 uc008piu.3 Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (PubMed:27137492). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity). Secreted In the embryo, expressed in the nasal mesenchyme. Sequence=AK081990; Type=Frameshift; Evidence=; ossification molecular_function extracellular region tissue regeneration regulation of neuron migration uc008piu.1 uc008piu.2 uc008piu.3 
ENSMUST00000039431.14 Ntrk3 ENSMUST00000039431.14 neurotrophic tyrosine kinase, receptor, type 3, transcript variant 1 (from RefSeq NM_008746.5) A4QPD0 ENSMUST00000039431.1 ENSMUST00000039431.10 ENSMUST00000039431.11 ENSMUST00000039431.12 ENSMUST00000039431.13 ENSMUST00000039431.2 ENSMUST00000039431.3 ENSMUST00000039431.4 ENSMUST00000039431.5 ENSMUST00000039431.6 ENSMUST00000039431.7 ENSMUST00000039431.8 ENSMUST00000039431.9 NM_008746 NTRK3_MOUSE Q6VNS1 Q9Z2P9 Q9Z2Q0 TrkC uc009hxf.1 uc009hxf.2 uc009hxf.3 uc009hxf.4 Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts with PTPRS (PubMed:25385546).Interacts with MAPK8IP3/JIP3 (By similarity). Q6VNS1; Q2MHE5: Dok6; NbExp=3; IntAct=EBI-16744951, EBI-20585476; Q6VNS1; P16056: Met; NbExp=5; IntAct=EBI-16744951, EBI-1798780; Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6VNS1-1; Sequence=Displayed; Name=2; Synonyms=TrkC NC1; IsoId=Q6VNS1-2; Sequence=VSP_021596, VSP_021597; Name=3; Synonyms=TrkC NC2; IsoId=Q6VNS1-3; Sequence=VSP_021598, VSP_021599; Isoform 2 expression is restricted to specific areas in adult brain. Isoform 3 transcripts are readily detected early during embryogenesis and are expressed predominantly in adult brain and gonads. Expression oscillates in a circadian manner in the liver. Ligand-mediated auto-phosphorylation. [Isoform 2]: Non-catalytic. [Isoform 3]: Non-catalytic. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. nucleotide binding activation of MAPK activity neuron migration negative regulation of protein phosphorylation p53 binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin receptor activity protein binding ATP binding cytoplasm mitochondrial outer membrane cytosol plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development heart development circadian rhythm positive regulation of cell proliferation positive regulation of gene expression positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation modulation by virus of host transcription neuronal action potential propagation myelination in peripheral nervous system cell differentiation positive regulation of cell migration axon activation of protein kinase B activity positive regulation of peptidyl-serine phosphorylation neurotrophin signaling pathway mechanoreceptor differentiation positive regulation of apoptotic process neurotrophin binding receptor complex regulation of MAPK cascade positive regulation of MAPK cascade response to ethanol ephrin receptor signaling pathway neuron fate specification response to axon injury positive regulation of axon extension involved in regeneration negative regulation of astrocyte differentiation positive regulation of positive chemotaxis response to corticosterone regulation of protein kinase B signaling positive regulation of synapse assembly negative regulation of cell death lens fiber cell differentiation cellular response to retinoic acid cochlea development activation of GTPase activity glutamatergic synapse integral component of postsynaptic membrane regulation of presynapse assembly cellular response to nerve growth factor stimulus positive regulation of actin cytoskeleton reorganization positive regulation of ERK1 and ERK2 cascade uc009hxf.1 uc009hxf.2 uc009hxf.3 uc009hxf.4 
ENSMUST00000039442.12 Alg14 ENSMUST00000039442.12 asparagine-linked glycosylation 14, transcript variant 2 (from RefSeq NR_155539.1) ALG14_MOUSE ENSMUST00000039442.1 ENSMUST00000039442.10 ENSMUST00000039442.11 ENSMUST00000039442.2 ENSMUST00000039442.3 ENSMUST00000039442.4 ENSMUST00000039442.5 ENSMUST00000039442.6 ENSMUST00000039442.7 ENSMUST00000039442.8 ENSMUST00000039442.9 NR_155539 Q8CEP2 Q9D081 uc008rdx.1 uc008rdx.2 uc008rdx.3 Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity). Heterodimer with ALG13 to form a functional enzyme. Endoplasmic reticulum membrane ; Single-pass membrane protein Nucleus membrane ; Single- pass membrane protein Belongs to the ALG14 family. nucleus endoplasmic reticulum endoplasmic reticulum membrane dolichol-linked oligosaccharide biosynthetic process membrane integral component of membrane nuclear membrane UDP-N-acetylglucosamine transferase complex N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity uc008rdx.1 uc008rdx.2 uc008rdx.3 
ENSMUST00000039447.14 Fndc3c1 ENSMUST00000039447.14 fibronectin type III domain containing 3C1 (from RefSeq NM_001007580.1) ENSMUST00000039447.1 ENSMUST00000039447.10 ENSMUST00000039447.11 ENSMUST00000039447.12 ENSMUST00000039447.13 ENSMUST00000039447.2 ENSMUST00000039447.3 ENSMUST00000039447.4 ENSMUST00000039447.5 ENSMUST00000039447.6 ENSMUST00000039447.7 ENSMUST00000039447.8 ENSMUST00000039447.9 FN3C1_MOUSE Fndc3c Gm784 NM_001007580 Q6DFV6 uc009ubs.1 uc009ubs.2 uc009ubs.3 uc009ubs.4 Membrane ; Single-pass membrane protein Belongs to the FNDC3 family. molecular_function cellular_component biological_process membrane integral component of membrane uc009ubs.1 uc009ubs.2 uc009ubs.3 uc009ubs.4 
ENSMUST00000039449.9 Ltn1 ENSMUST00000039449.9 listerin E3 ubiquitin protein ligase 1, transcript variant 2 (from RefSeq NM_001416035.1) E9QN94 ENSMUST00000039449.1 ENSMUST00000039449.2 ENSMUST00000039449.3 ENSMUST00000039449.4 ENSMUST00000039449.5 ENSMUST00000039449.6 ENSMUST00000039449.7 ENSMUST00000039449.8 Kiaa0714 LTN1_MOUSE Lister NM_001416035 Q6A009 Q6PIW6 Q8BZ44 Rnf160 Zfp294 Znf294 uc033gzo.1 uc033gzo.2 uc033gzo.3 E3 ubiquitin-protein ligase (PubMed:19196968). component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (By similarity). Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains (By similarity). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Component of the ribosome quality control complex (RQC), composed of at least the E3 ubiquitin ligase LTN1 and NEMF associated with the 60S ribosomal subunit. The complex probably also contains TCF25 as well as VCP/p97 and its ubiquitin-binding cofactors. Cytoplasm, cytosol Widely expressed, including in the brain and spinal cord. Autoubiquitinated. Embryonic lethality. Mice with a milder mutant caused by an internal in-frame deletion of exon 11, producing a 14- amino acid deletion prior to the RING-type zinc finger, display profound early-onset and progressive neurological and motor dysfunction. Was named listerin because of the 'tilting' or 'listing' phenotype observed in mutant mice. Belongs to the LTN1 family. Sequence=AAH27795.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAD32287.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; ubiquitin-protein transferase activity cytosol zinc ion binding protein ubiquitination transferase activity ribosomal large subunit binding proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding protein autoubiquitination ubiquitin protein ligase activity rescue of stalled ribosome RQC complex ribosome-associated ubiquitin-dependent protein catabolic process uc033gzo.1 uc033gzo.2 uc033gzo.3 
ENSMUST00000039450.5 Mcoln3 ENSMUST00000039450.5 mucolipin 3 (from RefSeq NM_134160.1) ENSMUST00000039450.1 ENSMUST00000039450.2 ENSMUST00000039450.3 ENSMUST00000039450.4 MCLN3_MOUSE NM_134160 Q8BS73 Q8BSG1 Q8CDB2 Q8R4F0 uc008rqx.1 uc008rqx.2 uc008rqx.3 Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:17989217). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (PubMed:18801844). Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (PubMed:24269818). Through a possible and probably tissue- specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (By similarity). Inhibited by lumenal H(+) and Na(+). The channel pore shows dynamic behavior and undergoes spontaneous, Ca(2+)-dependent modulation when conducting Ca(2+). Homotetramer. Can heterooligomerize with MCOLN1; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific. May heterooligomerize with TRPV5 to form a functional distinct ion channel (By similarity). Interacts with GABARAPL2 (PubMed:24269818). Early endosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein Cell projection, stereocilium membrane ; Multi-pass membrane protein Note=Recycles between the plasma membrane and intracellular compartments by a dynamin-dependent endocytic pathway (By similarity). In the cochlea located at the base of stereocilia near the position of the ankle links. Expressed in the cochlea; particularly in the inner and outer hair cells (at protein level). The most N-terminal extracellular/lumenal domain (referred to as I-II linker or polycystin-mucolipin domain) contributes to a structure with a four-fold rotational symmetry in a tetrameric assembly; the structure contains a central highly electronegative pore with a 14 A diameter. The pore is critical for Ca(2+) and pH regulation. The protruding structure formed by the I-II linkers may contain all the interaction sites with lipids and proteins in the endolysosomal lumen. N-glycosylated. Note=Defects in Mcoln3 are the cause of the varitin-waddler (Va) phenotype. Classical Va mice exhibit early-onset hearing loss, vestibular defects, pigmentation abnormalities and perinatal lethality. The phenotype varitin-waddler Jackcon (Va-J), which arose in a cross segregating for Va, is similar but less severe. No severe auditory and vestibular phenotype; does not lead to circling behavior, balance impairment or hearing loss. Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN3 sub-subfamily. Sequence=BAC27146.1; Type=Erroneous initiation; Evidence=; Sequence=BAC28123.1; Type=Erroneous initiation; Evidence=; Sequence=BAC28916.1; Type=Erroneous initiation; Evidence=; autophagosome membrane cation channel activity cytoplasm lysosomal membrane endosome plasma membrane ion transport locomotory behavior lipid binding membrane integral component of membrane cytoplasmic vesicle early endosome membrane late endosome membrane ion transmembrane transport auditory receptor cell differentiation cell projection release of sequestered calcium ion into cytosol stereocilium membrane NAADP-sensitive calcium-release channel activity cation transmembrane transport uc008rqx.1 uc008rqx.2 uc008rqx.3 
ENSMUST00000039476.15 Arhgef11 ENSMUST00000039476.15 Rho guanine nucleotide exchange factor 11, transcript variant 3 (from RefSeq NM_001360197.2) Arhgef11 ENSMUST00000039476.1 ENSMUST00000039476.10 ENSMUST00000039476.11 ENSMUST00000039476.12 ENSMUST00000039476.13 ENSMUST00000039476.14 ENSMUST00000039476.2 ENSMUST00000039476.3 ENSMUST00000039476.4 ENSMUST00000039476.5 ENSMUST00000039476.6 ENSMUST00000039476.7 ENSMUST00000039476.8 ENSMUST00000039476.9 NM_001360197 Q68FM7 Q68FM7_MOUSE uc008psm.1 uc008psm.2 uc008psm.3 Cytoplasm Membrane G-protein coupled receptor binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding cytoplasm G-protein coupled receptor signaling pathway Rho protein signal transduction regulation of Rho protein signal transduction intracellular signal transduction positive regulation of transcription, DNA-templated uc008psm.1 uc008psm.2 uc008psm.3 
ENSMUST00000039480.7 Zswim4 ENSMUST00000039480.7 zinc finger SWIM-type containing 4 (from RefSeq NM_172503.3) ENSMUST00000039480.1 ENSMUST00000039480.2 ENSMUST00000039480.3 ENSMUST00000039480.4 ENSMUST00000039480.5 ENSMUST00000039480.6 NM_172503 Q8BPN9 Q8C7B8 ZSWM4_MOUSE uc009mmg.1 uc009mmg.2 uc009mmg.3 Q8C7B8; Q61545: Ewsr1; NbExp=2; IntAct=EBI-26673088, EBI-1606991; Sequence=BAC35466.1; Type=Erroneous initiation; Evidence=; molecular_function zinc ion binding Cul2-RING ubiquitin ligase complex metal ion binding regulation of axon guidance uc009mmg.1 uc009mmg.2 uc009mmg.3 
ENSMUST00000039484.6 Zc3h12d ENSMUST00000039484.6 zinc finger CCCH type containing 12D (from RefSeq NM_172785.3) E9QNR7 E9QNR7_MOUSE ENSMUST00000039484.1 ENSMUST00000039484.2 ENSMUST00000039484.3 ENSMUST00000039484.4 ENSMUST00000039484.5 NM_172785 Zc3h12d uc007eiq.1 uc007eiq.2 uc007eiq.3 uc007eiq.4 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the ZC3H12 family. P-body nucleoplasm cytoplasmic ribonucleoprotein granule metal ion binding uc007eiq.1 uc007eiq.2 uc007eiq.3 uc007eiq.4 
ENSMUST00000039487.10 Gtf2h5 ENSMUST00000039487.10 general transcription factor IIH, polypeptide 5, transcript variant 1 (from RefSeq NM_181392.3) D17Wsu155e ENSMUST00000039487.1 ENSMUST00000039487.2 ENSMUST00000039487.3 ENSMUST00000039487.4 ENSMUST00000039487.5 ENSMUST00000039487.6 ENSMUST00000039487.7 ENSMUST00000039487.8 ENSMUST00000039487.9 Gtf2h5 NM_181392 Q8BT75 Q8K2X8 TF2H5_MOUSE uc008aga.1 uc008aga.2 uc008aga.3 uc008aga.4 uc008aga.5 Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK- activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. (Microbial infection) Interacts with the vesicular stomatitis virus matrix protein/M; this interaction may lead to transcription inhibition. Nucleus Cytoplasm Belongs to the TFB5 family. core TFIIH complex maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleus transcription factor TFIID complex holo TFIIH complex nucleolus DNA repair nucleotide-excision repair nucleotide-excision repair, preincision complex assembly regulation of transcription, DNA-templated transcription elongation from RNA polymerase I promoter transcription from RNA polymerase II promoter cellular response to DNA damage stimulus phosphorylation of RNA polymerase II C-terminal domain cellular response to gamma radiation uc008aga.1 uc008aga.2 uc008aga.3 uc008aga.4 uc008aga.5 
ENSMUST00000039490.9 Tnfsf9 ENSMUST00000039490.9 tumor necrosis factor (ligand) superfamily, member 9 (from RefSeq NM_009404.3) ENSMUST00000039490.1 ENSMUST00000039490.2 ENSMUST00000039490.3 ENSMUST00000039490.4 ENSMUST00000039490.5 ENSMUST00000039490.6 ENSMUST00000039490.7 ENSMUST00000039490.8 NM_009404 Q3U1Z9 Q3U1Z9_MOUSE Tnfsf9 uc008ded.1 uc008ded.2 uc008ded.3 Belongs to the tumor necrosis factor family. cytokine activity tumor necrosis factor receptor binding extracellular space immune response signal transduction membrane integral component of membrane tumor necrosis factor receptor superfamily binding uc008ded.1 uc008ded.2 uc008ded.3 
ENSMUST00000039492.14 Kng1 ENSMUST00000039492.14 kininogen 1, transcript variant 2 (from RefSeq NM_023125.3) ENSMUST00000039492.1 ENSMUST00000039492.10 ENSMUST00000039492.11 ENSMUST00000039492.12 ENSMUST00000039492.13 ENSMUST00000039492.2 ENSMUST00000039492.3 ENSMUST00000039492.4 ENSMUST00000039492.5 ENSMUST00000039492.6 ENSMUST00000039492.7 ENSMUST00000039492.8 ENSMUST00000039492.9 KNG1_MOUSE Kng NM_023125 O08676 O08677 Q32MX7 Q6S9I1 Q91XK5 uc007ytc.1 uc007ytc.2 uc007ytc.3 Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. [Bradykinin]: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action). Isoform LMW interacts with CRISP3. Secreted, extracellular space. Event=Alternative splicing; Named isoforms=3; Name=HMW; IsoId=O08677-1; Sequence=Displayed; Name=LMW; IsoId=O08677-2; Sequence=VSP_001263, VSP_001264; Name=3; IsoId=O08677-3; Sequence=VSP_037159; Plasma. Bradykinin is released from kininogen by plasma kallikrein. Phosphorylated by FAM20C in the extracellular medium. [Bradykinin]: Bradykinin is inactivated by ACE, which removes the dipeptide Arg-Phe from its C-terminus. cysteine-type endopeptidase inhibitor activity receptor binding extracellular region extracellular space cell inflammatory response positive regulation of cytosolic calcium ion concentration blood coagulation hemostasis negative regulation of peptidase activity negative regulation of endopeptidase activity negative regulation of blood coagulation peptidase inhibitor activity vasodilation uc007ytc.1 uc007ytc.2 uc007ytc.3 
ENSMUST00000039500.4 Tmc1 ENSMUST00000039500.4 transmembrane channel-like gene family 1 (from RefSeq NM_028953.2) Bth ENSMUST00000039500.1 ENSMUST00000039500.2 ENSMUST00000039500.3 NM_028953 Q7TQB2 Q8R4P5 Q9D435 TMC1_MOUSE dn uc008gyp.1 uc008gyp.2 Probable ion channel required for the normal function of cochlear hair cells. Interacts with TOMT (PubMed:28504928, PubMed:28534737). The interaction of TMC1 and TMC2 with TOMT is required for the transportation of TMC1/2 into the stereocilia of hair cells (PubMed:28504928, PubMed:28534737). Interacts (via N-terminus) with both isoforms CD1 and CD3 of PCDH15 (PubMed:25114259). Interacts with CIB2 (PubMed:28663585, PubMed:34089643). Interacts with CIB3 (PubMed:34089643). Cell membrane ulti-pass membrane protein Note=Localized to the stereocilia of the cochlear hair cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R4P5-1; Sequence=Displayed; Name=2; IsoId=Q8R4P5-2; Sequence=VSP_006435, VSP_006436, VSP_006437; Detected in cochlear inner and outer hair cells and in neurosensory epithelia of the vestibular end organs. Also expressed in cortex, cerebellum, eye, colon, ovary and testis. Expressed at low, constant levels in temporal bone from embryonic day 14 to day 1 after birth. Increases by 8 to 16-fold at day 5, 10 and 20 and continues to be expressed up to day 90. Note=Defects in Tmc1 are the cause of the dominant deaf mutant Beethoven (BTH). Heterozygotes show progressive hair-cell degeneration from day 20 onwards, leading to severe depletion of inner hair cells and scattered loss of outer hair cells, and progressive loss of the Preyer reflex from around day 30. Homozygotes show almost complete degeneration of inner hair cells, and little or no Preyer reflex at any age. Note=Defects in Tmc1 are the cause of recessive deaf mutant dn. The dn mutant shows profound deafness with degeneration of the organ of Corti, stria vascularis, and occasionally the saccular macula, starting at about 10 days after birth (PubMed:11850618). Belongs to the TMC family. ion channel activity voltage-gated calcium channel activity protein binding plasma membrane integral component of plasma membrane ion transport sensory perception of sound mechanically-gated ion channel activity external side of plasma membrane membrane integral component of membrane stereocilium tip detection of mechanical stimulus involved in sensory perception of sound vestibular reflex auditory receptor cell development calcium ion transmembrane transport regulation of calcium ion transmembrane transport uc008gyp.1 uc008gyp.2 
ENSMUST00000039507.15 Oscar ENSMUST00000039507.15 osteoclast associated receptor, transcript variant 1 (from RefSeq NM_175632.3) ENSMUST00000039507.1 ENSMUST00000039507.10 ENSMUST00000039507.11 ENSMUST00000039507.12 ENSMUST00000039507.13 ENSMUST00000039507.14 ENSMUST00000039507.2 ENSMUST00000039507.3 ENSMUST00000039507.4 ENSMUST00000039507.5 ENSMUST00000039507.6 ENSMUST00000039507.7 ENSMUST00000039507.8 ENSMUST00000039507.9 NM_175632 OSCAR_MOUSE Q8VBT3 Q8VHT9 uc009evb.1 uc009evb.2 uc009evb.3 uc009evb.4 uc009evb.5 Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=OSCAR-M2; IsoId=Q8VBT3-1; Sequence=Displayed; Name=2; Synonyms=OSCAR-M3; IsoId=Q8VBT3-2; Sequence=VSP_029356; Specifically expressed in preosteoclasts or mature osteoclasts. Belongs to the leukocyte receptor complex/polymeric immunoglobulin receptor (PIR/LRC) family. protein binding plasma membrane cell surface membrane integral component of membrane osteoclast differentiation interleukin-2 production collagen receptor activity collagen-activated signaling pathway Fc-gamma receptor signaling pathway positive regulation of bone resorption multinuclear osteoclast differentiation uc009evb.1 uc009evb.2 uc009evb.3 uc009evb.4 uc009evb.5 
ENSMUST00000039516.4 Egln3 ENSMUST00000039516.4 egl-9 family hypoxia-inducible factor 3 (from RefSeq NM_028133.2) A0A0R4J0H9 A0A0R4J0H9_MOUSE ENSMUST00000039516.1 ENSMUST00000039516.2 ENSMUST00000039516.3 Egln3 NM_028133 uc007nns.1 uc007nns.2 uc007nns.3 uc007nns.4 Reaction=2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia- inducible factor alpha subunit]; Xref=Rhea:RHEA:48400, Rhea:RHEA- COMP:12093, Rhea:RHEA-COMP:12094, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50342, ChEBI:CHEBI:61965; EC=1.14.11.29; Evidence=; Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; response to hypoxia iron ion binding nucleus cytoplasm cytosol apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors protein hydroxylation peptidyl-proline hydroxylation to 4-hydroxy-L-proline L-ascorbic acid binding peptidyl-proline 4-dioxygenase activity regulation of cell proliferation oxidation-reduction process uc007nns.1 uc007nns.2 uc007nns.3 uc007nns.4 
ENSMUST00000039522.8 Apobr ENSMUST00000039522.8 apolipoprotein B receptor (from RefSeq NM_138310.1) APOBR_MOUSE Apob48r Apobr ENSMUST00000039522.1 ENSMUST00000039522.2 ENSMUST00000039522.3 ENSMUST00000039522.4 ENSMUST00000039522.5 ENSMUST00000039522.6 ENSMUST00000039522.7 NM_138310 Q8VBT6 uc009jsb.1 uc009jsb.2 uc009jsb.3 uc009jsb.4 Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. Homodimer. Cell membrane ; Peripheral membrane protein Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein (By similarity). Highly expressed in spleen, lung and skeletal muscle, and weakly in brain, heart, kidney, and testis. Finds at the highest levels in 7 dpc, then progressively lower at 11 dpc and 15 dpc, and finally very diminished at the 17 dpc. Increased in high-fat diet ATM (adipose tissue macrophages). There are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R). plasma membrane lipid metabolic process triglyceride metabolic process lipid transport endocytosis steroid metabolic process cholesterol metabolic process membrane lipoprotein particle receptor activity very-low-density lipoprotein particle receptor activity very-low-density lipoprotein particle low-density lipoprotein particle chylomicron uc009jsb.1 uc009jsb.2 uc009jsb.3 uc009jsb.4 
ENSMUST00000039534.11 Resp18 ENSMUST00000039534.11 regulated endocrine-specific protein 18, transcript variant 2 (from RefSeq NR_138251.1) ENSMUST00000039534.1 ENSMUST00000039534.10 ENSMUST00000039534.2 ENSMUST00000039534.3 ENSMUST00000039534.4 ENSMUST00000039534.5 ENSMUST00000039534.6 ENSMUST00000039534.7 ENSMUST00000039534.8 ENSMUST00000039534.9 NR_138251 P47939 RES18_MOUSE uc007bos.1 uc007bos.2 uc007bos.3 This gene encodes a secreted protein that is expressed mainly in the peripheral endocrine and neuroendocrine tissues and is regulated by physiological factors that include blood glucose and dopaminergic drugs. The encoded protein is found in the lumen of the endoplasmic reticulum and is degraded in the post-ER pre-Golgi compartment. Gene knockout experiments in mice demonstrate that this gene is essential for embryonic development with embryonic lethality occurring before embryonic day 9.5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]. May play an important regulatory role in corticotrophs. Endoplasmic reticulum Golgi apparatus Cytoplasmic vesicle, secretory vesicle lumen Note=Found in the lumen of secretory vesicles (dense core vesicles, DCV) (By similarity). However, seems to be retained intracellularly and not secreted (PubMed:7988462). Pituitary, hypothalamus and pancreas. Highest levels are found in somatotrophes, mammotrophes, and gonadotrophes, and lower levels are found in corticotrophs and thyrotropes. Up-regulated by high levels of glucose. Belongs to the RESP18 family. in utero embryonic development molecular_function endoplasmic reticulum Golgi apparatus secretory granule cytoplasmic vesicle perikaryon rough endoplasmic reticulum lumen uc007bos.1 uc007bos.2 uc007bos.3 
ENSMUST00000039551.9 Polr3k ENSMUST00000039551.9 polymerase (RNA) III (DNA directed) polypeptide K (from RefSeq NM_025901.3) ENSMUST00000039551.1 ENSMUST00000039551.2 ENSMUST00000039551.3 ENSMUST00000039551.4 ENSMUST00000039551.5 ENSMUST00000039551.6 ENSMUST00000039551.7 ENSMUST00000039551.8 NM_025901 Polr3k Q9CQZ7 Q9D1U1 RPC10_MOUSE uc008onw.1 uc008onw.2 uc008onw.3 uc008onw.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (By similarity). Pol III-mediated transcription proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol III is recruited to DNA promoters type I, II or III with the help of general transcription factors and other specific initiation factors. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity). POLR3K/RPC10 anchors to the Pol III active site to constantly monitor the fidelity of Pol III transcription, catalyzes the cleavage of backtracked mis-incorporated nucleotides and restarts the transcription process. Once Pol III reaches poly(dT) termination signal, can induce Pol III clamp opening and transcription termination (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity). Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3- POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Nucleus Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. immune system process nucleic acid binding DNA-directed 5'-3' RNA polymerase activity nucleus DNA-directed RNA polymerase III complex nucleolus transcription, DNA-templated termination of RNA polymerase III transcription zinc ion binding tRNA 3'-trailer cleavage innate immune response metal ion binding defense response to virus RNA polymerase III activity uc008onw.1 uc008onw.2 uc008onw.3 uc008onw.4 
ENSMUST00000039554.7 Trmt6 ENSMUST00000039554.7 tRNA methyltransferase 6, transcript variant 1 (from RefSeq NM_175113.3) ENSMUST00000039554.1 ENSMUST00000039554.2 ENSMUST00000039554.3 ENSMUST00000039554.4 ENSMUST00000039554.5 ENSMUST00000039554.6 Kiaa1153 NM_175113 Q3TJZ8 Q3TME7 Q6ZPW8 Q80Y59 Q8CE96 Q8CEU0 TRM6_MOUSE Trm6 uc008mng.1 uc008mng.2 uc008mng.3 Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries. Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CE96-1; Sequence=Displayed; Name=3; IsoId=Q8CE96-3; Sequence=VSP_018026; Name=4; IsoId=Q8CE96-4; Sequence=VSP_018026, VSP_018027, VSP_018028; Belongs to the TRM6/GCD10 family. Sequence=BAC98110.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC98110.1; Type=Frameshift; Evidence=; nucleus tRNA processing tRNA methylation tRNA (m1A) methyltransferase complex mRNA methylation tRNA (adenine-N1-)-methyltransferase activity uc008mng.1 uc008mng.2 uc008mng.3 
ENSMUST00000039557.9 Arhgap18 ENSMUST00000039557.9 Rho GTPase activating protein 18 (from RefSeq NM_176837.2) Arhgap18 ENSMUST00000039557.1 ENSMUST00000039557.2 ENSMUST00000039557.3 ENSMUST00000039557.4 ENSMUST00000039557.5 ENSMUST00000039557.6 ENSMUST00000039557.7 ENSMUST00000039557.8 NM_176837 Q8BP03 Q8K0Q5 Q8R196 RHG18_MOUSE uc007ese.1 uc007ese.2 uc007ese.3 Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1. Regulates cell shape, spreading, and migration (By similarity). Interacts with MPHOSPH6. Cytoplasm Widely expressed: expressed in most organs, except small intestine. GTPase activator activity cytoplasm cytosol plasma membrane signal transduction small GTPase mediated signal transduction regulation of cell shape nuclear speck regulation of actin filament polymerization regulation of actin cytoskeleton organization positive regulation of GTPase activity regulation of small GTPase mediated signal transduction regulation of cell motility uc007ese.1 uc007ese.2 uc007ese.3 
ENSMUST00000039559.9 Thbs1 ENSMUST00000039559.9 thrombospondin 1, transcript variant 1 (from RefSeq NM_011580.4) ENSMUST00000039559.1 ENSMUST00000039559.2 ENSMUST00000039559.3 ENSMUST00000039559.4 ENSMUST00000039559.5 ENSMUST00000039559.6 ENSMUST00000039559.7 ENSMUST00000039559.8 NM_011580 Q80YQ1 Q80YQ1_MOUSE Thbs1 uc008lrq.1 uc008lrq.2 uc008lrq.3 The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. Belongs to the thrombospondin family. Lacks conserved residue(s) required for the propagation of feature annotation. activation of MAPK activity phosphatidylserine binding negative regulation of endothelial cell proliferation negative regulation of cell-matrix adhesion fibronectin binding sprouting angiogenesis chronic inflammatory response negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of dendritic cell antigen processing and presentation integrin binding calcium ion binding extracellular region fibrinogen complex extracellular space cytoplasm inflammatory response immune response cell cycle arrest cell adhesion heparin binding positive regulation of cell proliferation response to mechanical stimulus response to glucose external side of plasma membrane cell surface positive regulation of endothelial cell migration negative regulation of endothelial cell migration negative regulation of plasma membrane long-chain fatty acid transport negative regulation of nitric oxide mediated signal transduction negative regulation of cGMP-mediated signaling negative regulation of plasminogen activation positive regulation of fibroblast migration cell migration negative regulation of angiogenesis fibroblast growth factor binding peptide cross-linking secretory granule low-density lipoprotein particle binding positive regulation of blood coagulation positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway extracellular matrix platelet alpha granule response to magnesium ion negative regulation of interleukin-12 production response to testosterone negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of phosphorylation response to drug positive regulation of tumor necrosis factor biosynthetic process positive regulation of macrophage activation negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process laminin binding positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration engulfment of apoptotic cell positive regulation of translation positive regulation of angiogenesis positive regulation of smooth muscle cell proliferation transforming growth factor beta binding extracellular matrix binding positive regulation of chemotaxis response to calcium ion positive regulation of protein kinase B signaling negative regulation of fibrinolysis fibrinogen binding collagen V binding cellular response to tumor necrosis factor cellular response to growth factor stimulus positive regulation of transforming growth factor beta production negative regulation of cell migration involved in sprouting angiogenesis positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of sprouting angiogenesis positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process negative regulation of endothelial cell chemotaxis uc008lrq.1 uc008lrq.2 uc008lrq.3 
ENSMUST00000039568.11 Pcdh8 ENSMUST00000039568.11 protocadherin 8, transcript variant 1 (from RefSeq NM_021543.5) ENSMUST00000039568.1 ENSMUST00000039568.10 ENSMUST00000039568.2 ENSMUST00000039568.3 ENSMUST00000039568.4 ENSMUST00000039568.5 ENSMUST00000039568.6 ENSMUST00000039568.7 ENSMUST00000039568.8 ENSMUST00000039568.9 NM_021543 PCDH8_MOUSE Papc Q05BD0 Q7TSK3 Q8C824 Q9JKP3 uc007uti.1 uc007uti.2 uc007uti.3 uc007uti.4 uc007uti.5 This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a type I transmembrane protein composed of an extracellular domain including 6 cadherin ectodomains, a single-pass transmembrane domain and a cytoplasmic tail. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons with the first large exon encoding the extracellular and transmembrane region. Although this gene product is capable of homophilic interaction, it appears to affect cell-cell adhesion indirectly by initiating signaling events that regulate classical cadherin-mediated adhesion. Based on studies on this protein and its orthologs, this protocadherin mainly functions in developing embryos and the central nervous system, but can also function as a tumor suppressor. Alternative splicing yielding isoforms with unique cytoplasmic tails has been reported. [provided by RefSeq, Sep 2009]. Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway (By similarity). In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis. The N-terminal extracellular domain forms homophilic interactions; these interactions activate p38 MAPK via TAOK2 and trigger endocytosis. Interacts with CDH2; this interaction may lead to CDH2 cointernalization. Interacts with CDH11. Interacts with TAOK2. Cell membrane ; Single-pass type I membrane protein Cell projection, dendrite Presynaptic cell membrane. Postsynaptic cell membrane Note=Expressed in neuronal cell bodies and dendrites. Localized to excitatory, but not with inhibitory, synapses. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7TSK3-1; Sequence=Displayed; Name=2; IsoId=Q7TSK3-2; Sequence=VSP_040562; Name=3; IsoId=Q7TSK3-3; Sequence=VSP_040563, VSP_040564; [Isoform 3]: Due to intron retention. somitogenesis calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules chemical synaptic transmission membrane integral component of membrane morphogenesis of embryonic epithelium cell junction dendrite presynaptic membrane cell projection synapse postsynaptic membrane modulation of synaptic transmission glutamatergic synapse integral component of postsynaptic membrane uc007uti.1 uc007uti.2 uc007uti.3 uc007uti.4 uc007uti.5 
ENSMUST00000039571.14 2410004B18Rik ENSMUST00000039571.14 RIKEN cDNA 2410004B18 gene, transcript variant 1 (from RefSeq NM_025555.5) CA052_MOUSE ENSMUST00000039571.1 ENSMUST00000039571.10 ENSMUST00000039571.11 ENSMUST00000039571.12 ENSMUST00000039571.13 ENSMUST00000039571.2 ENSMUST00000039571.3 ENSMUST00000039571.4 ENSMUST00000039571.5 ENSMUST00000039571.6 ENSMUST00000039571.7 ENSMUST00000039571.8 ENSMUST00000039571.9 NM_025555 Q9CRP5 Q9CWU4 uc008rqt.1 uc008rqt.2 uc008rqt.3 Belongs to the UPF0690 family. Sequence=BAB31704.1; Type=Erroneous initiation; Evidence=; nucleus biological_process uc008rqt.1 uc008rqt.2 uc008rqt.3 
ENSMUST00000039577.8 Zfp51 ENSMUST00000039577.8 zinc finger protein 51, transcript variant 1 (from RefSeq NM_009558.4) ENSMUST00000039577.1 ENSMUST00000039577.2 ENSMUST00000039577.3 ENSMUST00000039577.4 ENSMUST00000039577.5 ENSMUST00000039577.6 ENSMUST00000039577.7 NM_009558 Q3U4L8 Q3U4L8_MOUSE Zfp51 uc008aqv.1 uc008aqv.2 uc008aqv.3 uc008aqv.4 uc008aqv.5 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc008aqv.1 uc008aqv.2 uc008aqv.3 uc008aqv.4 uc008aqv.5 
ENSMUST00000039597.14 Clec18a ENSMUST00000039597.14 Secreted (from UniProt Q7TSQ1) AK132888 CL18A_MOUSE ENSMUST00000039597.1 ENSMUST00000039597.10 ENSMUST00000039597.11 ENSMUST00000039597.12 ENSMUST00000039597.13 ENSMUST00000039597.2 ENSMUST00000039597.3 ENSMUST00000039597.4 ENSMUST00000039597.5 ENSMUST00000039597.6 ENSMUST00000039597.7 ENSMUST00000039597.8 ENSMUST00000039597.9 Mrcl Mrlp Q7TMA7 Q7TSP9 Q7TSQ0 Q7TSQ1 Q7TSQ7 uc292dgd.1 uc292dgd.2 Secreted Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Form 2; IsoId=Q7TSQ1-1; Sequence=Displayed; Name=2; Synonyms=Form 4; IsoId=Q7TSQ1-2; Sequence=VSP_032209; Name=3; IsoId=Q7TSQ1-3; Sequence=VSP_032211; Name=4; Synonyms=Form 6; IsoId=Q7TSQ1-4; Sequence=VSP_032210; Name=5; Synonyms=Form 3; IsoId=Q7TSQ1-5; Sequence=VSP_032208; extracellular region extracellular space biological_process carbohydrate binding polysaccharide binding uc292dgd.1 uc292dgd.2 
ENSMUST00000039601.10 Snrnp25 ENSMUST00000039601.10 small nuclear ribonucleoprotein 25 (U11/U12) (from RefSeq NM_030093.3) ENSMUST00000039601.1 ENSMUST00000039601.2 ENSMUST00000039601.3 ENSMUST00000039601.4 ENSMUST00000039601.5 ENSMUST00000039601.6 ENSMUST00000039601.7 ENSMUST00000039601.8 ENSMUST00000039601.9 NM_030093 Q8VIK1 Q9CX75 SNR25_MOUSE uc007ija.1 uc007ija.2 uc007ija.3 uc007ija.4 uc007ija.5 Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Nucleus mRNA splicing, via spliceosome molecular_function nucleus nucleoplasm spliceosomal complex U12-type spliceosomal complex cytosol mRNA processing biological_process RNA splicing intercellular bridge uc007ija.1 uc007ija.2 uc007ija.3 uc007ija.4 uc007ija.5 
ENSMUST00000039605.8 Fam50b ENSMUST00000039605.8 family with sequence similarity 50, member B, transcript variant 2 (from RefSeq NM_001382856.1) D0H6S2654E ENSMUST00000039605.1 ENSMUST00000039605.2 ENSMUST00000039605.3 ENSMUST00000039605.4 ENSMUST00000039605.5 ENSMUST00000039605.6 ENSMUST00000039605.7 FA50B_MOUSE NM_001382856 Q80X84 Q9D993 Q9WTJ8 X5l uc007qbl.1 uc007qbl.2 uc007qbl.3 Widely expressed. Abundant in testis, where it is expressed in seminiferous tubules, not in the interstitium. At the cellular level, expressed in primary spermatocytes and round spermatids, but not detectable in spermatogonia, elongating spermatids, mature spermatozoa, Sertoli cells or Leydig cells. Belongs to the FAM50 family. Sequence=AK007247; Type=Frameshift; Evidence=; nucleus nucleoplasm intercellular bridge uc007qbl.1 uc007qbl.2 uc007qbl.3 
ENSMUST00000039608.9 Dym ENSMUST00000039608.9 dymeclin, transcript variant 2 (from RefSeq NM_027727.3) DYM_MOUSE ENSMUST00000039608.1 ENSMUST00000039608.2 ENSMUST00000039608.3 ENSMUST00000039608.4 ENSMUST00000039608.5 ENSMUST00000039608.6 ENSMUST00000039608.7 ENSMUST00000039608.8 NM_027727 Q3U3F3 Q3UDW2 Q569W1 Q8C7M2 Q8CHY3 Q8VCZ4 uc008fpz.1 uc008fpz.2 uc008fpz.3 Necessary for correct organization of Golgi apparatus. Involved in bone development. Interacts with GOLM1 and PPIB. Cytoplasm. Golgi apparatus Membrane ; Lipid-anchor Note=Sequence analysis programs predict 1 transmembrane region. However, it has been shown in human that it is not a stably anchored transmembrane protein but it weakly associates with the Golgi apparatus and shuttles between the Golgi and the cytosol (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CHY3-1; Sequence=Displayed; Name=2; IsoId=Q8CHY3-2; Sequence=VSP_036444, VSP_036445; Myristoylated in vitro; myristoylation is not essential for protein targeting to Golgi compartment. Belongs to the dymeclin family. Sequence=AAH18220.1; Type=Erroneous initiation; Evidence=; Sequence=BAC33983.1; Type=Erroneous initiation; Evidence=; Sequence=BAE32833.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; cytoplasm Golgi apparatus Golgi organization membrane enzyme binding bone development uc008fpz.1 uc008fpz.2 uc008fpz.3 
ENSMUST00000039610.10 Xylb ENSMUST00000039610.10 xylulokinase homolog (H. influenzae), transcript variant 3 (from RefSeq NM_001359699.1) B2RR66 ENSMUST00000039610.1 ENSMUST00000039610.2 ENSMUST00000039610.3 ENSMUST00000039610.4 ENSMUST00000039610.5 ENSMUST00000039610.6 ENSMUST00000039610.7 ENSMUST00000039610.8 ENSMUST00000039610.9 NM_001359699 Q3TNA1 Q8R156 XYLB_MOUSE uc009sat.1 uc009sat.2 uc009sat.3 uc009sat.4 Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. Reaction=ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+); Xref=Rhea:RHEA:10964, ChEBI:CHEBI:15378, ChEBI:CHEBI:17140, ChEBI:CHEBI:30616, ChEBI:CHEBI:57737, ChEBI:CHEBI:456216; EC=2.7.1.17; Monomer. Belongs to the FGGY kinase family. Sequence=AAH25442.1; Type=Erroneous initiation; Evidence=; nucleotide binding xylulokinase activity ATP binding cytosol carbohydrate metabolic process xylulose metabolic process kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor D-xylose metabolic process carbohydrate phosphorylation uc009sat.1 uc009sat.2 uc009sat.3 uc009sat.4 
ENSMUST00000039620.7 Cbr3 ENSMUST00000039620.7 carbonyl reductase 3 (from RefSeq NM_173047.3) CBR3_MOUSE ENSMUST00000039620.1 ENSMUST00000039620.2 ENSMUST00000039620.3 ENSMUST00000039620.4 ENSMUST00000039620.5 ENSMUST00000039620.6 NM_173047 Q8K354 uc007zzs.1 uc007zzs.2 uc007zzs.3 uc007zzs.4 Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, as well as on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified. Reaction=a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH; Xref=Rhea:RHEA:19257, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.184; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19258; Evidence=; Reaction=a quinone + H(+) + NADPH = a quinol + NADP(+); Xref=Rhea:RHEA:46164, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132124; EC=1.6.5.10; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46165; Evidence=; Cytoplasm Belongs to the short-chain dehydrogenases/reductases (SDR) family. 3-keto sterol reductase activity carbonyl reductase (NADPH) activity nucleoplasm cytoplasm cytosol oxidoreductase activity phylloquinone catabolic process cognition oxidation-reduction process NADPH binding uc007zzs.1 uc007zzs.2 uc007zzs.3 uc007zzs.4 
ENSMUST00000039630.6 Ror1 ENSMUST00000039630.6 receptor tyrosine kinase-like orphan receptor 1, transcript variant 1 (from RefSeq NM_013845.5) ENSMUST00000039630.1 ENSMUST00000039630.2 ENSMUST00000039630.3 ENSMUST00000039630.4 ENSMUST00000039630.5 NM_013845 Ntrkr1 Q8BG10 Q9Z139 ROR1_MOUSE uc008tvd.1 uc008tvd.2 uc008tvd.3 uc008tvd.4 This gene encodes a receptor tyrosine kinase that has been implicated in nervous system development, specifically in the maintenance of neural progenitor cell fate, neurite extension and synapse formation. The encoded protein, likely a pseudokinase that lacks catalytic activity, may also regulate adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (By similarity). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Membrane ; Single- pass type I membrane protein. Cell projection, axon At postnatal P0, expressed in heart, lung, liver, kidney, spleen and inner ear. At postnatal P0, expressed in heart, lung, liver, kidney, spleen and inner ear (PubMed:27162350). In the inner ear, at 14.5 dpc, detected in spiral ganglia, the cochlear epithelium and the vesitbule. At 17.5 dpc, expression increases in spiral ganglion neurons axon terminals adjacent to auditory hair cells. In the differentiating cochlear epithelium, the expression is intense in the stria vascularis. By P0, expression in the stria vascularis is weakened (PubMed:27162350). Mutant mice are severely deaf, with preserved otoacoustic emissions. They have malformed cochleae with fasciculation defects in axons of spiral ganglion neurons. Type I neurons show impaired synapses with inner hair cells and type II neurons display aberrant projections through the cochlear sensory epithelium. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. nucleotide binding stress fiber protein kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding cytoplasm plasma membrane integral component of plasma membrane protein phosphorylation nervous system development sensory perception of sound cell surface positive regulation of neuron projection development astrocyte development positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane Wnt signaling pathway Wnt-protein binding peptidyl-tyrosine phosphorylation axon Wnt-activated receptor activity cell projection positive regulation of I-kappaB kinase/NF-kappaB signaling receptor complex regulation of MAPK cascade positive regulation of MAPK cascade axon terminus inner ear development anatomical structure development positive regulation of NF-kappaB transcription factor activity transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of ERK1 and ERK2 cascade uc008tvd.1 uc008tvd.2 uc008tvd.3 uc008tvd.4 
ENSMUST00000039631.10 Acta2 ENSMUST00000039631.10 actin alpha 2, smooth muscle, aorta (from RefSeq NM_007392.3) ACTA_MOUSE Actsa Actvs ENSMUST00000039631.1 ENSMUST00000039631.2 ENSMUST00000039631.3 ENSMUST00000039631.4 ENSMUST00000039631.5 ENSMUST00000039631.6 ENSMUST00000039631.7 ENSMUST00000039631.8 ENSMUST00000039631.9 NM_007392 P03996 P04108 P62737 uc008hgg.1 uc008hgg.2 uc008hgg.3 uc008hgg.4 uc008hgg.5 The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK156331.1, AK017374.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Cytoplasm, cytoskeleton. Expressed in the liver (at protein level). Expressed in mesentery venous vessels at 17.5 dpc. Induced by S.japonicum egg-mediated liver fibrosis at the site of egg granulomas; expression peakes at 12 weeks post infection with expression decreasing thereafter. Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization. Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity). Methylated at His-75 by SETD3. [Actin, aortic smooth muscle, intermediate form]: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP. In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Belongs to the actin family. nucleotide binding stress fiber protein binding ATP binding cytoplasm cytoskeleton muscle contraction regulation of blood pressure response to virus positive regulation of gene expression vascular smooth muscle contraction actin cytoskeleton protein kinase binding lamellipodium filopodium smooth muscle contractile fiber macromolecular complex cell body regulation of wound healing positive regulation of ERK1 and ERK2 cascade glomerular mesangial cell development mesenchyme migration positive regulation of hepatic stellate cell activation uc008hgg.1 uc008hgg.2 uc008hgg.3 uc008hgg.4 uc008hgg.5 
ENSMUST00000039652.6 Ins1 ENSMUST00000039652.6 insulin I (from RefSeq NM_008386.4) ENSMUST00000039652.1 ENSMUST00000039652.2 ENSMUST00000039652.3 ENSMUST00000039652.4 ENSMUST00000039652.5 INS1_MOUSE Ins-1 NM_008386 P01325 Q545I7 Q9D907 uc008hwd.1 uc008hwd.2 uc008hwd.3 uc008hwd.4 uc008hwd.5 uc008hwd.6 This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP773571.1, BP776899.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds. Secreted. Belongs to the insulin family. activation of MAPK activity protease binding insulin receptor binding hormone activity extracellular region extracellular space cytoplasm cytosol carbohydrate metabolic process glucose metabolic process signal transduction response to organic substance regulation of gene expression secretory granule endocrine pancreas development response to cytokine secretory granule lumen glucose homeostasis response to peptide hormone positive regulation of peptidyl-tyrosine phosphorylation chaperone binding response to cAMP glucose transmembrane transport uc008hwd.1 uc008hwd.2 uc008hwd.3 uc008hwd.4 uc008hwd.5 uc008hwd.6 
ENSMUST00000039655.3 Tulp4 ENSMUST00000039655.3 TUB like protein 4, transcript variant 1 (from RefSeq NM_054040.3) B2RQP8 ENSMUST00000039655.1 ENSMUST00000039655.2 NM_054040 Q8CA75 Q922C2 Q9JIL5 TULP4_MOUSE Tusp uc008agh.1 uc008agh.2 uc008agh.3 uc008agh.4 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Cytoplasm. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. Belongs to the TUB family. cytoplasm protein ubiquitination uc008agh.1 uc008agh.2 uc008agh.3 uc008agh.4 
ENSMUST00000039659.9 Cbr1 ENSMUST00000039659.9 carbonyl reductase 1 (from RefSeq NM_007620.3) CBR1_MOUSE Cbr Cbr1 ENSMUST00000039659.1 ENSMUST00000039659.2 ENSMUST00000039659.3 ENSMUST00000039659.4 ENSMUST00000039659.5 ENSMUST00000039659.6 ENSMUST00000039659.7 ENSMUST00000039659.8 NM_007620 P48758 Q91X28 uc007zzr.1 uc007zzr.2 uc007zzr.3 NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH- dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267, PubMed:33785425). Reaction=a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH; Xref=Rhea:RHEA:19257, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.184; Evidence=; Reaction=NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin E2; Xref=Rhea:RHEA:24508, ChEBI:CHEBI:15378, ChEBI:CHEBI:57404, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:606564; EC=1.1.1.189; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:24510; Evidence=; Reaction=NADP(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:11636, ChEBI:CHEBI:15378, ChEBI:CHEBI:57397, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.197; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11637; Evidence=; Reaction=H(+) + menadione + NADPH = menadiol + NADP(+); Xref=Rhea:RHEA:63492, ChEBI:CHEBI:6746, ChEBI:CHEBI:15378, ChEBI:CHEBI:28869, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Reaction=NADP(+) + prostaglandin D2 = 15-oxoprostaglandin D2 + H(+) + NADPH; Xref=Rhea:RHEA:20744, ChEBI:CHEBI:15378, ChEBI:CHEBI:57406, ChEBI:CHEBI:57408, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.196; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20745; Evidence=; Reaction=NADP(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADPH; Xref=Rhea:RHEA:63476, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:606564; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63477; Evidence=; Reaction=NADP(+) + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:63480, ChEBI:CHEBI:15378, ChEBI:CHEBI:57404, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133409; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63481; Evidence=; Reaction=daunorubicin + H(+) + NADPH = 13-dihydrodaunorubicin + NADP(+); Xref=Rhea:RHEA:63504, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:64677, ChEBI:CHEBI:75296; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63505; Evidence=; Reaction=H(+) + NADPH + S-nitrosoglutathione = NADP(+) + sulfinamide glutathione; Xref=Rhea:RHEA:63500, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:145544, ChEBI:CHEBI:145547; Evidence=; Reaction=corticosterone + H(+) + NADPH = 20beta-dihydrocorticosterone + NADP(+); Xref=Rhea:RHEA:70219, ChEBI:CHEBI:15378, ChEBI:CHEBI:16827, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:189050; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70220; Evidence=; Reaction=a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH; Xref=Rhea:RHEA:15937, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:17478, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.71; Evidence=; Reaction=cortisol + H(+) + NADPH = 20beta-dihydrocortisol + NADP(+); Xref=Rhea:RHEA:70215, ChEBI:CHEBI:15378, ChEBI:CHEBI:17650, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:139311; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70216; Evidence=; Monomer. Cytoplasm Embryonic lethal. Belongs to the short-chain dehydrogenases/reductases (SDR) family. carbonyl reductase (NADPH) activity nucleus cytoplasm plasma membrane microvillus oxidoreductase activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor drug metabolic process vitamin K metabolic process intracellular membrane-bounded organelle 15-hydroxyprostaglandin dehydrogenase (NADP+) activity prostaglandin-E2 9-reductase activity oxidation-reduction process uc007zzr.1 uc007zzr.2 uc007zzr.3 
ENSMUST00000039666.8 Plekhs1 ENSMUST00000039666.8 pleckstrin homology domain containing, family S member 1, transcript variant 1 (from RefSeq NM_172641.3) E9QMW0 ENSMUST00000039666.1 ENSMUST00000039666.2 ENSMUST00000039666.3 ENSMUST00000039666.4 ENSMUST00000039666.5 ENSMUST00000039666.6 ENSMUST00000039666.7 NM_172641 PKHS1_MOUSE Plekhs1 Q5EAT4 Q8BW88 Q8BZ18 Q8R5A9 uc008hyy.1 uc008hyy.2 uc008hyy.3 uc008hyy.4 Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BW88-1; Sequence=Displayed; Name=2; IsoId=Q8BW88-2; Sequence=VSP_031732, VSP_031735, VSP_031736; Name=3; IsoId=Q8BW88-3; Sequence=VSP_031732, VSP_031733; Name=4; IsoId=Q8BW88-4; Sequence=VSP_031734; Sequence=BAC29634.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process uc008hyy.1 uc008hyy.2 uc008hyy.3 uc008hyy.4 
ENSMUST00000039672.6 Mfsd9 ENSMUST00000039672.6 major facilitator superfamily domain containing 9 (from RefSeq NM_172499.2) ENSMUST00000039672.1 ENSMUST00000039672.2 ENSMUST00000039672.3 ENSMUST00000039672.4 ENSMUST00000039672.5 MFSD9_MOUSE NM_172499 Q8C0T7 uc007auo.1 uc007auo.2 uc007auo.3 Membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. integral component of plasma membrane membrane integral component of membrane transmembrane transporter activity transmembrane transport uc007auo.1 uc007auo.2 uc007auo.3 
ENSMUST00000039674.13 Pknox2 ENSMUST00000039674.13 Pbx/knotted 1 homeobox 2, transcript variant 7 (from RefSeq NM_001424689.1) ENSMUST00000039674.1 ENSMUST00000039674.10 ENSMUST00000039674.11 ENSMUST00000039674.12 ENSMUST00000039674.2 ENSMUST00000039674.3 ENSMUST00000039674.4 ENSMUST00000039674.5 ENSMUST00000039674.6 ENSMUST00000039674.7 ENSMUST00000039674.8 ENSMUST00000039674.9 NM_001424689 PKNX2_MOUSE Prep2 Q8BG99 Q8R4B0 uc009oue.1 uc009oue.2 uc009oue.3 uc009oue.4 uc009oue.5 Nucleus Belongs to the TALE/MEIS homeobox family. Sequence=AAM18702.1; Type=Erroneous initiation; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding actin monomer binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter actin cytoskeleton microtubule cytoskeleton sequence-specific DNA binding intercellular bridge actin filament binding uc009oue.1 uc009oue.2 uc009oue.3 uc009oue.4 uc009oue.5 
ENSMUST00000039680.7 Parp11 ENSMUST00000039680.7 poly (ADP-ribose) polymerase family, member 11, transcript variant 1 (from RefSeq NM_181402.4) ENSMUST00000039680.1 ENSMUST00000039680.2 ENSMUST00000039680.3 ENSMUST00000039680.4 ENSMUST00000039680.5 ENSMUST00000039680.6 NM_181402 PAR11_MOUSE Parp11 Q3UAF2 Q3UZR7 Q8CFF0 uc009dvy.1 uc009dvy.2 uc009dvy.3 Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins (By similarity). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (PubMed:25673562). Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA- COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=; Reaction=L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP- D-ribosyl)-L-cysteinyl-[protein]; Xref=Rhea:RHEA:56612, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:14624, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29950, ChEBI:CHEBI:57540, ChEBI:CHEBI:140607; Evidence=; Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence=; Reaction=L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L- lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58220, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:15088, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:142515; Evidence=; Nucleus, nuclear pore complex Note=Colocalizes with NUP153 at nuclear pores. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CFF0-1; Sequence=Displayed; Name=2; IsoId=Q8CFF0-2; Sequence=VSP_022557; Name=3; IsoId=Q8CFF0-3; Sequence=VSP_022558; Predominantly expressed in testis, preferentially in postmeiotic germ cells. Also detectable in other tissues, including liver, lung, spleen, thymus and brain. Undetectable in testis until postnatal day 18. Sharply up-regulated from postnatal days 18 to 21. This timeframe corresponds to the appearance of the first spermatids of the first wave of spermatogenesis just before initiation of elongation. Remains elevated in adult animals. Auto-mono-ADP-ribosylated. Knockout mice are viable and are born in normal Mendelian ratios. Knockout males, but not females, exhibit a striking fertility defect, with the majority of males being sterile and a minority producing infrequent and small litters. Sperm from mutant mice exhibits mild to severe teratozoospermia, with structural defects in elongating spermatid nuclear envelope and chromatin detachment associated with abnormal nuclear shaping. Belongs to the ARTD/PARP family. NAD+ ADP-ribosyltransferase activity nucleus nuclear envelope nuclear pore nuclear envelope organization spermatogenesis protein transport transferase activity transferase activity, transferring glycosyl groups cell differentiation mRNA transport protein auto-ADP-ribosylation protein ADP-ribosylase activity uc009dvy.1 uc009dvy.2 uc009dvy.3 
ENSMUST00000039694.13 Stard3nl ENSMUST00000039694.13 STARD3 N-terminal like, transcript variant 1 (from RefSeq NM_024270.3) ENSMUST00000039694.1 ENSMUST00000039694.10 ENSMUST00000039694.11 ENSMUST00000039694.12 ENSMUST00000039694.2 ENSMUST00000039694.3 ENSMUST00000039694.4 ENSMUST00000039694.5 ENSMUST00000039694.6 ENSMUST00000039694.7 ENSMUST00000039694.8 ENSMUST00000039694.9 Mentho NM_024270 Q3U8Q7 Q99J63 Q9D356 Q9DCI3 STR3N_MOUSE Stard3nl uc007ppa.1 uc007ppa.2 uc007ppa.3 uc007ppa.4 Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB. Homodimer. Interacts (via the MENTAL domain) with STARD3NL. Interacts (via FFAT motif) with VAPA. Interacts (via FFAT motif) with VAPB. Interacts (via FFAT motif) with MOSPD2 (via MSP domain). Late endosome membrane ; Multi-pass membrane protein Note=Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA, VAPB or MOSPD2. The FFAT motif mediates interaction with VAPA, VAPB and MOSPD2. The MENTAL domain anchors the protein in endosome membranes and exposes the START domain in the cytosol (By similarity). It binds cholesterol and mediates homotypic as well as heterotypic interactions between STARD3 and STARD3NL (By similarity). Belongs to the STARD3 family. endosome cholesterol binding membrane integral component of membrane late endosome membrane protein homodimerization activity intracellular membrane-bounded organelle organelle membrane contact site vesicle tethering to endoplasmic reticulum endoplasmic reticulum membrane uc007ppa.1 uc007ppa.2 uc007ppa.3 uc007ppa.4 
ENSMUST00000039695.7 Frem3 ENSMUST00000039695.7 Fras1 related extracellular matrix protein 3 (from RefSeq NM_001167898.1) ENSMUST00000039695.1 ENSMUST00000039695.2 ENSMUST00000039695.3 ENSMUST00000039695.4 ENSMUST00000039695.5 ENSMUST00000039695.6 F8WHZ0 F8WHZ0_MOUSE Frem3 NM_001167898 uc012ggm.1 uc012ggm.2 uc012ggm.3 Belongs to the FRAS1 family. basement membrane cell communication integral component of membrane uc012ggm.1 uc012ggm.2 uc012ggm.3 
ENSMUST00000039697.14 Gabrb3 ENSMUST00000039697.14 GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3, transcript variant 1 (from RefSeq NM_008071.3) ENSMUST00000039697.1 ENSMUST00000039697.10 ENSMUST00000039697.11 ENSMUST00000039697.12 ENSMUST00000039697.13 ENSMUST00000039697.2 ENSMUST00000039697.3 ENSMUST00000039697.4 ENSMUST00000039697.5 ENSMUST00000039697.6 ENSMUST00000039697.7 ENSMUST00000039697.8 ENSMUST00000039697.9 GBRB3_MOUSE Gabrb-3 NM_008071 P15433 P63080 Q3UHR3 uc009hee.1 uc009hee.2 uc009hee.3 uc009hee.4 Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:9108119). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA- gated ion channel (PubMed:27129275). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275). The alpha1/beta3/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (PubMed:27129275). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Plays an important role in somatosensation and in the production of antinociception (PubMed:10670447). Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (By similarity). Can form functional homopentamers (in vitro) (By similarity). Interacts with UBQLN1 (By similarity). May interact with KIF21B (By similarity). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Interacts with LHFPL4 (PubMed:28978485). Interacts with GIT1; this interaction is required for synaptic GABRB3 surface stability and inhibitory synapse strength (By similarity). Postsynaptic cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane Important perinatal lethality. About 57% of the pups have a cleft palate. About 90% of the pups die within 24 hours after birth, including 30% of those that do not have a cleft palate. Surviving mice are runted until weaning, but attain normal body weight in adulthood. They are hyperactive and display behavorial abnormalities. They do not display jerky gait, but have difficulty with swimming, walking on grids, and avoiding to fall from rotarods. Mutant mice are fertile, but females do not display normal nurturing behavior. Mutant mice have abnormal electroencephalograms (EEGs) and tend to suffer from seizures. Brains from mutant mice show strongly reduced numbers of GABA and benzodiazepine receptors. Neurons from dorsal root ganglion show a decrease of about 80% of GABA-induced chloride currents. In addition, mutant mice have an average lifespan of about 18 weeks, instead of the expected 127 weeks (PubMed:9108119). Mutant mice display a lowered threshold to nociception and are abnormally sensitive to touch and heat stimuli. GABA receptor agonists have decreased antinociceptive effects in mutant mice (PubMed:10670447). Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub- subfamily. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity chloride channel activity protein binding plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction gamma-aminobutyric acid signaling pathway chemical synaptic transmission sensory perception of sound membrane integral component of membrane GABA-gated chloride ion channel activity cell junction cytoplasmic vesicle membrane cytoplasmic vesicle ion transmembrane transport chloride channel complex AP-2 adaptor complex binding regulation of membrane potential identical protein binding neuron projection terminal bouton regulation of neuron apoptotic process negative regulation of neuron apoptotic process synapse postsynaptic membrane neuron development neurological system process synaptic transmission, GABAergic palate development inhibitory synapse inhibitory postsynaptic potential inner ear receptor cell development innervation cellular response to histamine cochlea development GABA-ergic synapse integral component of postsynaptic membrane integral component of postsynaptic specialization membrane negative regulation of neuron death chloride transmembrane transport GABA-A receptor complex transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential inhibitory synapse assembly uc009hee.1 uc009hee.2 uc009hee.3 uc009hee.4 
ENSMUST00000039720.11 Rragb ENSMUST00000039720.11 Ras-related GTP binding B (from RefSeq NM_001004154.2) B1AVD6 ENSMUST00000039720.1 ENSMUST00000039720.10 ENSMUST00000039720.2 ENSMUST00000039720.3 ENSMUST00000039720.4 ENSMUST00000039720.5 ENSMUST00000039720.6 ENSMUST00000039720.7 ENSMUST00000039720.8 ENSMUST00000039720.9 NM_001004154 Q6NTA4 RRAGB_MOUSE Rragb uc012hqx.1 uc012hqx.2 uc012hqx.3 Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagB/RRAGB is in its active form when GTP- bound RagB/RRAGB forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagB/RRAGB heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD). In its GTP- bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; The activation of GTP-binding proteins is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). The Ragulator complex functions as a GEF and promotes the active GTP-bound form. The GATOR1 complex functions as a GAP and stimulates RRAGB GTPase activity to turn it into its inactive GDP-bound form, preventing mTORC1 recruitment and activation. Interacts with RRAGC and RRAGD; heterodimerization stabilizes RRAG proteins (By similarity). The GTP-bound form of RRAGB (in complex with the GDP-bound form of RRAGC or RRAGD) interacts with RPTOR, thereby promoting recruitment of mTORC1 to the lysosomes (By similarity). Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator (By similarity). Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR (By similarity). Interacts with the GATOR1 complex; inactivates RRAGB (By similarity). The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor. Interacts with SESN1, SESN2 and SESN3 (PubMed:25259925). Cytoplasm Lysosome membrane Note=Recruited to the lysosome surface by the Ragulator complex. Belongs to the GTR/RAG GTP-binding protein family. nucleotide binding GTPase activity GTP binding nucleus cytoplasm lysosome cellular response to starvation regulation of autophagy regulation of TOR signaling positive regulation of TOR signaling guanyl ribonucleotide binding cellular response to amino acid starvation EGO complex cellular protein localization protein heterodimerization activity GTPase binding cellular response to amino acid stimulus positive regulation of TORC1 signaling Gtr1-Gtr2 GTPase complex cellular response to leucine starvation uc012hqx.1 uc012hqx.2 uc012hqx.3 
ENSMUST00000039721.14 Slc17a3 ENSMUST00000039721.14 solute carrier family 17 (sodium phosphate), member 3, transcript variant 1 (from RefSeq NM_134069.3) ENSMUST00000039721.1 ENSMUST00000039721.10 ENSMUST00000039721.11 ENSMUST00000039721.12 ENSMUST00000039721.13 ENSMUST00000039721.2 ENSMUST00000039721.3 ENSMUST00000039721.4 ENSMUST00000039721.5 ENSMUST00000039721.6 ENSMUST00000039721.7 ENSMUST00000039721.8 ENSMUST00000039721.9 G3UWD9 G3UWD9_MOUSE G5E894 NM_134069 Slc17a3 uc007pvd.1 uc007pvd.2 uc007pvd.3 Membrane ; Multi- pass membrane protein cytoplasm endoplasmic reticulum membrane integral component of plasma membrane voltage-gated anion channel activity organic anion transmembrane transporter activity urate transmembrane transporter activity efflux transmembrane transporter activity inorganic anion transport organic anion transport urate transport membrane integral component of membrane apical plasma membrane toxin transporter activity xenobiotic transporter activity urate metabolic process perinuclear region of cytoplasm transmembrane transport toxin transport drug transmembrane export uc007pvd.1 uc007pvd.2 uc007pvd.3 
ENSMUST00000039725.12 Exo1 ENSMUST00000039725.12 exonuclease 1 (from RefSeq NM_012012.4) ENSMUST00000039725.1 ENSMUST00000039725.10 ENSMUST00000039725.11 ENSMUST00000039725.2 ENSMUST00000039725.3 ENSMUST00000039725.4 ENSMUST00000039725.5 ENSMUST00000039725.6 ENSMUST00000039725.7 ENSMUST00000039725.8 ENSMUST00000039725.9 EXO1_MOUSE NM_012012 Q3TLM4 Q923A5 Q9QZ11 uc007dtu.1 uc007dtu.2 uc007dtu.3 uc007dtu.4 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding. ; Interacts with the MLH1-PMS2 heterodimer via MLH1. Interacts with MSH3. Interacts with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'->3' exonuclease activity. Interacts with PCNA, and this interaction may both stimulate the cryptic 3'->5' exonuclease activity and suppress the 5'->3' exonuclease activity. Interacts with WRN, and this interaction stimulates both the 5'->3' exonuclease activity and cleavage of 5'- overhanging flap structures. Interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5'-overhanging flap structures. Interacts with DNA helicase ZGRF1; the interaction is increased following DNA damage induction. Nucleus Note=Colocalizes with PCNA to discrete nuclear foci in S-phase. Highly expressed in the spleen and testis. Also expressed in the bone marrow, brain, lung, lymph node and thymus. Postnatal expression in the testis is elevated at the onset of pachytene (day 14). Phosphorylated upon DNA damage and in response to agents stalling DNA replication, probably by ATM or ATR. Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily. immune system process humoral immune response mediated by circulating immunoglobulin DNA binding chromatin binding catalytic activity nuclease activity endonuclease activity exonuclease activity nucleus nucleoplasm plasma membrane nucleobase-containing compound metabolic process DNA repair mismatch repair DNA recombination cellular response to DNA damage stimulus 5'-3' exonuclease activity somatic hypermutation of immunoglobulin genes nuclear body hydrolase activity hydrolase activity, acting on ester bonds 5'-flap endonuclease activity 5'-3' exodeoxyribonuclease activity single-stranded DNA 5'-3' exodeoxyribonuclease activity isotype switching metal ion binding flap endonuclease activity meiotic cell cycle double-stranded DNA 5'-3' exodeoxyribonuclease activity nucleic acid phosphodiester bond hydrolysis uc007dtu.1 uc007dtu.2 uc007dtu.3 uc007dtu.4 
ENSMUST00000039729.5 Etfrf1 ENSMUST00000039729.5 electron transfer flavoprotein regulatory factor 1, transcript variant 8 (from RefSeq NM_001362058.1) B2KFC1 ENSMUST00000039729.1 ENSMUST00000039729.2 ENSMUST00000039729.3 ENSMUST00000039729.4 ETFR1_MOUSE Etfrf1 Lyrm5 NM_001362058 Q675B1 Q8VDL7 Q91V16 uc291kee.1 uc291kee.2 Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). homotetramer. Interacts with NDUFAB1. Interacts with ETFA. Interacts with ETFB. Mitochondrion Belongs to the complex I LYR family. molecular_function mitochondrion respiratory electron transport chain uc291kee.1 uc291kee.2 
ENSMUST00000039733.10 Osbpl11 ENSMUST00000039733.10 oxysterol binding protein-like 11 (from RefSeq NM_176840.3) ENSMUST00000039733.1 ENSMUST00000039733.2 ENSMUST00000039733.3 ENSMUST00000039733.4 ENSMUST00000039733.5 ENSMUST00000039733.6 ENSMUST00000039733.7 ENSMUST00000039733.8 ENSMUST00000039733.9 G5E8A0 G5E8A0_MOUSE NM_176840 Osbpl11 uc007yzy.1 uc007yzy.2 uc007yzy.3 Belongs to the OSBP family. nucleoplasm Golgi apparatus lipid transport positive regulation of sequestering of triglyceride fat cell differentiation uc007yzy.1 uc007yzy.2 uc007yzy.3 
ENSMUST00000039734.12 Unkl ENSMUST00000039734.12 unkempt family like zinc finger, transcript variant 4 (from RefSeq NM_001357876.1) ENSMUST00000039734.1 ENSMUST00000039734.10 ENSMUST00000039734.11 ENSMUST00000039734.2 ENSMUST00000039734.3 ENSMUST00000039734.4 ENSMUST00000039734.5 ENSMUST00000039734.6 ENSMUST00000039734.7 ENSMUST00000039734.8 ENSMUST00000039734.9 NM_001357876 Q5FWH2 Q6RUT6 Q9DBK4 UNKL_MOUSE uc012ana.1 uc012ana.2 uc012ana.3 uc012ana.4 May participate in a protein complex showing an E3 ligase activity regulated by Rac1. Ubiquitination is directed towards itself and possibly other substrates, such as Baf60b/Smarcd2. Intrinsic E3 ligase activity has not been proven. Protein modification; protein ubiquitination. Interacts with the GTP-bound form of Rac1. Interacts with Baf60b/Smarcd2 (By similarity). Cytoplasm Nucleus Note=Primarily localized in the cytoplasm but has the ability to shuttle between the nucleus and the cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q5FWH2-3; Sequence=Displayed; Name=1; IsoId=Q5FWH2-1; Sequence=VSP_039444; Name=2; IsoId=Q5FWH2-2; Sequence=VSP_039445, VSP_039446, VSP_039447; Ubiquitous. Although this protein contains a RING domain, intrinsic E3 ligase activity has not been proven. Ubiquitination is enhanced by activated Rac1. The presence of the RING finger domain is not essential for ubiquitination to occur (By similarity). Belongs to the unkempt family. nucleus cytoplasm cytosol biological_process protein ubiquitination transferase activity metal ion binding uc012ana.1 uc012ana.2 uc012ana.3 uc012ana.4 
ENSMUST00000039742.8 Hykk ENSMUST00000039742.8 hydroxylysine kinase 1 (from RefSeq NM_177351.4) Agphd1 ENSMUST00000039742.1 ENSMUST00000039742.2 ENSMUST00000039742.3 ENSMUST00000039742.4 ENSMUST00000039742.5 ENSMUST00000039742.6 ENSMUST00000039742.7 HYKK_MOUSE NM_177351 Q3TQ48 Q3TRW8 Q3UU28 Q5U5V2 Q8C3L8 uc009prs.1 uc009prs.2 uc009prs.3 uc009prs.4 Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L- lysine. Reaction=(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+); Xref=Rhea:RHEA:19049, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:57882, ChEBI:CHEBI:58189, ChEBI:CHEBI:58357; EC=2.7.1.81; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5U5V2-1; Sequence=Displayed; Name=2; IsoId=Q5U5V2-2; Sequence=VSP_032521, VSP_032522; Belongs to the aminoglycoside phosphotransferase family. cellular_component cytoplasm kinase activity phosphorylation transferase activity hydroxylysine kinase activity uc009prs.1 uc009prs.2 uc009prs.3 uc009prs.4 
ENSMUST00000039752.4 Slc16a8 ENSMUST00000039752.4 solute carrier family 16 (monocarboxylic acid transporters), member 8 (from RefSeq NM_020516.2) ENSMUST00000039752.1 ENSMUST00000039752.2 ENSMUST00000039752.3 NM_020516 Q5UB50 Q5UB50_MOUSE Slc16a8 uc007wta.1 uc007wta.2 uc007wta.3 Basolateral cell membrane ; Multi-pass membrane protein Lateral cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein integral component of plasma membrane monocarboxylic acid transmembrane transporter activity lactate transmembrane transporter activity monocarboxylic acid transport membrane integral component of membrane lactate transmembrane transport transmembrane transport uc007wta.1 uc007wta.2 uc007wta.3 
ENSMUST00000039758.6 Cox8a ENSMUST00000039758.6 cytochrome c oxidase subunit 8A (from RefSeq NM_007750.2) COX8A_MOUSE Cox8 Cox8l ENSMUST00000039758.1 ENSMUST00000039758.2 ENSMUST00000039758.3 ENSMUST00000039758.4 ENSMUST00000039758.5 NM_007750 Q0VBB1 Q545I2 Q64445 uc008gkj.1 uc008gkj.2 uc008gkj.3 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Energy metabolism; oxidative phosphorylation. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the cytochrome c oxidase VIII family. cytochrome-c oxidase activity mitochondrion mitochondrial inner membrane membrane integral component of membrane electron transport chain respiratory chain complex IV hydrogen ion transmembrane transport uc008gkj.1 uc008gkj.2 uc008gkj.3 
ENSMUST00000039763.14 Ginm1 ENSMUST00000039763.14 glycoprotein integral membrane 1, transcript variant 1 (from RefSeq NM_145418.4) ENSMUST00000039763.1 ENSMUST00000039763.10 ENSMUST00000039763.11 ENSMUST00000039763.12 ENSMUST00000039763.13 ENSMUST00000039763.2 ENSMUST00000039763.3 ENSMUST00000039763.4 ENSMUST00000039763.5 ENSMUST00000039763.6 ENSMUST00000039763.7 ENSMUST00000039763.8 ENSMUST00000039763.9 GINM1_MOUSE NM_145418 Q91WR6 uc011wzz.1 uc011wzz.2 Membrane ; Single-pass type I membrane protein molecular_function biological_process membrane integral component of membrane uc011wzz.1 uc011wzz.2 
ENSMUST00000039769.13 Sntb1 ENSMUST00000039769.13 syntrophin, basic 1, transcript variant 1 (from RefSeq NM_016667.4) ENSMUST00000039769.1 ENSMUST00000039769.10 ENSMUST00000039769.11 ENSMUST00000039769.12 ENSMUST00000039769.2 ENSMUST00000039769.3 ENSMUST00000039769.4 ENSMUST00000039769.5 ENSMUST00000039769.6 ENSMUST00000039769.7 ENSMUST00000039769.8 ENSMUST00000039769.9 NM_016667 O35925 Q99L88 SNTB1_MOUSE Snt2b1 uc007vsk.1 uc007vsk.2 uc007vsk.3 Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. Monomer and homodimer (Probable). Interacts with the viral HTLV-1 TAX protein and other members of the syntrophin family: SNTA1 and SNTB2 (By similarity). Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN and with the sodium channel proteins SCN4A and SCN5A. Interacts with DTNB (PubMed:10893187). Q99L88; P25100: ADRA1D; Xeno; NbExp=2; IntAct=EBI-295943, EBI-489993; Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side Cell junction Cytoplasm, cytoskeleton Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99L88-1; Sequence=Displayed; Name=2; IsoId=Q99L88-2; Sequence=VSP_006356, VSP_006357; Ubiquitous. Expressed at high levels in the liver. The PH 1 domain mediates the oligomerization in a calcium dependent manner. The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity). The SU domain binds calmodulin in a calcium-dependent manner. Phosphorylated by CaM-kinase II. Belongs to the syntrophin family. actin binding structural molecule activity protein binding calmodulin binding cytoplasm cytoskeleton plasma membrane dystrophin-associated glycoprotein complex membrane cell junction PDZ domain binding macromolecular complex sarcolemma synapse uc007vsk.1 uc007vsk.2 uc007vsk.3 
ENSMUST00000039775.9 Lgi4 ENSMUST00000039775.9 leucine-rich repeat LGI family, member 4, transcript variant 1 (from RefSeq NM_144556.3) ENSMUST00000039775.1 ENSMUST00000039775.2 ENSMUST00000039775.3 ENSMUST00000039775.4 ENSMUST00000039775.5 ENSMUST00000039775.6 ENSMUST00000039775.7 ENSMUST00000039775.8 LGI4_MOUSE Lgil3 NM_144556 Q8K1S1 Q8K4Y8 uc009ghz.1 uc009ghz.2 uc009ghz.3 Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation. Can bind to ADAM11, ADAM22 and ADAM23. Secreted Brain. Expressed in the entire developing peripheral nerves. Strongly expressed in the trigeminal nerve and ganglion and particularly abundant in the boundary cap cells - a transient population of cells that contributes to the Schwann cell population of the dorsal root nerve. Expressed at 14 dpc. Note=Defects in Lgi4 are the cause of the claw paw (clp) phenotype. Mice are characterized by limb posture abnormalities and peripheral hypomyelination, with no sign of dysmyelination in the CNS. protein binding extracellular region extracellular space adult locomotory behavior glial cell proliferation Schwann cell development glial cell development myelination in peripheral nervous system regulation of myelination gliogenesis neuron maturation myelination uc009ghz.1 uc009ghz.2 uc009ghz.3 
ENSMUST00000039782.14 Chd6 ENSMUST00000039782.14 chromodomain helicase DNA binding protein 6, transcript variant 2 (from RefSeq NR_126509.1) A3KFM7 B9EKA7 CHD6_MOUSE ENSMUST00000039782.1 ENSMUST00000039782.10 ENSMUST00000039782.11 ENSMUST00000039782.12 ENSMUST00000039782.13 ENSMUST00000039782.2 ENSMUST00000039782.3 ENSMUST00000039782.4 ENSMUST00000039782.5 ENSMUST00000039782.6 ENSMUST00000039782.7 ENSMUST00000039782.8 ENSMUST00000039782.9 Kiaa1335 NR_126509 Q3UQS6 Q80TE9 uc008nrn.1 uc008nrn.2 uc008nrn.3 uc008nrn.4 This gene encodes a member of the chromodomain/helicase/DNA-binding domain family of chromatin remodeling enzymes. This protein has been found to be specifically involved in transcription initiation and elongation. Homozygous knockout mice exhibit impaired motor coordination. A pseudogene has been identified on chromosome 8. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]. DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Interacts with NFE2L2; involved in activation of the transcription. Nucleus, nucleoplasm Note=Enriched at sites of mRNA synthesis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A3KFM7-1; Sequence=Displayed; Name=2; IsoId=A3KFM7-2; Sequence=VSP_054901; Widely expressed. Mice with targeted deletion of exon 12 lacking part of the Helicase ATP-binding domain are born in normal Mendelian ratios and are viable. They are fertile and exhibit no obvious morphological or histological difference. However, they display a coordination deficiency which is not due to muscle weakness or bradykinesia. Belongs to the SNF2/RAD54 helicase family. Sequence=BAC65778.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC65778.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Spurious priming from an intronic poly-A tract.; Evidence=; nucleotide binding transcription cofactor binding DNA binding DNA helicase activity helicase activity ATP binding nucleus nucleoplasm chromatin organization DNA-dependent ATPase activity hydrolase activity hydrolase activity, acting on acid anhydrides DNA duplex unwinding positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress uc008nrn.1 uc008nrn.2 uc008nrn.3 uc008nrn.4 
ENSMUST00000039784.12 Acaa1a ENSMUST00000039784.12 acetyl-Coenzyme A acyltransferase 1A, transcript variant 1 (from RefSeq NM_130864.3) Acaa1 Acaa1a ENSMUST00000039784.1 ENSMUST00000039784.10 ENSMUST00000039784.11 ENSMUST00000039784.2 ENSMUST00000039784.3 ENSMUST00000039784.4 ENSMUST00000039784.5 ENSMUST00000039784.6 ENSMUST00000039784.7 ENSMUST00000039784.8 ENSMUST00000039784.9 NM_130864 Q921H8 THIKA_MOUSE uc009sas.1 uc009sas.2 uc009sas.3 Responsible for the thiolytic cleavage of straight chain 3- keto fatty acyl-CoAs (3-oxoacyl-CoAs) (Probable). Plays an important role in fatty acid peroxisomal beta-oxidation (Probable). Catalyzes the cleavage of short, medium, long, and very long straight chain 3- oxoacyl-CoAs (By similarity). Reaction=acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA; Xref=Rhea:RHEA:21564, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58342, ChEBI:CHEBI:90726; EC=2.3.1.16; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21566; Evidence=; Reaction=2 acetyl-CoA = acetoacetyl-CoA + CoA; Xref=Rhea:RHEA:21036, ChEBI:CHEBI:57286, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.9; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21038; Evidence=; Reaction=acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA; Xref=Rhea:RHEA:18161, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57349, ChEBI:CHEBI:57385; EC=2.3.1.155; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18163; Evidence=; Reaction=acetyl-CoA + hexanoyl-CoA = 3-oxooctanoyl-CoA + CoA; Xref=Rhea:RHEA:31203, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:62619, ChEBI:CHEBI:62620; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31205; Evidence=; Reaction=3-oxohexadecanedioyl-CoA + CoA = acetyl-CoA + tetradecanedioyl-CoA; Xref=Rhea:RHEA:40343, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:77081, ChEBI:CHEBI:77084; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40344; Evidence=; Reaction=3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA; Xref=Rhea:RHEA:39131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74298, ChEBI:CHEBI:74304; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39132; Evidence=; Lipid metabolism; peroxisomal fatty acid beta-oxidation. Homodimer. Interacts (via PTS2-type peroxisomal targeting signal region) with PEX7; leading to its translocation into peroxisomes. Peroxisome Note=Transported into peroxisomes following association with PEX7. Mainly expressed in liver and intestine. The PTS2-type peroxisomal targeting signal, which mediates interaction with PEX7 and localization to peroxisomes, is cleaved following import into peroxisomes. Belongs to the thiolase-like superfamily. Thiolase family. very long-chain fatty acid metabolic process catalytic activity acetyl-CoA C-acetyltransferase activity acetyl-CoA C-acyltransferase activity mitochondrion peroxisome peroxisomal matrix lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation bile acid metabolic process acetate CoA-transferase activity phenylacetate catabolic process palmitoyl-CoA oxidase activity transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups intracellular membrane-bounded organelle uc009sas.1 uc009sas.2 uc009sas.3 
ENSMUST00000039796.14 Gucd1 ENSMUST00000039796.14 guanylyl cyclase domain containing 1, transcript variant 1 (from RefSeq NM_175133.2) ENSMUST00000039796.1 ENSMUST00000039796.10 ENSMUST00000039796.11 ENSMUST00000039796.12 ENSMUST00000039796.13 ENSMUST00000039796.2 ENSMUST00000039796.3 ENSMUST00000039796.4 ENSMUST00000039796.5 ENSMUST00000039796.6 ENSMUST00000039796.7 ENSMUST00000039796.8 ENSMUST00000039796.9 GUCD1_MOUSE NM_175133 Q147V8 Q3TZX7 Q80XN8 Q8BLZ0 Q8BZI6 uc007fqk.1 uc007fqk.2 uc007fqk.3 Sequence=BAC28736.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process uc007fqk.1 uc007fqk.2 uc007fqk.3 
ENSMUST00000039798.16 Bbs9 ENSMUST00000039798.16 Bardet-Biedl syndrome 9, transcript variant 2 (from RefSeq NM_181316.4) ENSMUST00000039798.1 ENSMUST00000039798.10 ENSMUST00000039798.11 ENSMUST00000039798.12 ENSMUST00000039798.13 ENSMUST00000039798.14 ENSMUST00000039798.15 ENSMUST00000039798.2 ENSMUST00000039798.3 ENSMUST00000039798.4 ENSMUST00000039798.5 ENSMUST00000039798.6 ENSMUST00000039798.7 ENSMUST00000039798.8 ENSMUST00000039798.9 NM_181316 P97498 PTHB1_MOUSE Pthb1 Q3UMR2 Q7TQH9 Q811G0 Q8BKD7 Q8K0T5 uc009oor.1 uc009oor.2 The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization (By similarity). Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts with LZTL1; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. Cell projection, cilium membrane Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q811G0-1; Sequence=Displayed; Name=2; IsoId=Q811G0-2; Sequence=VSP_018430; Name=3; IsoId=Q811G0-3; Sequence=VSP_018429, VSP_018431, VSP_018432; Name=4; IsoId=Q811G0-4; Sequence=VSP_018429; Sequence=AAH30419.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; pericentriolar material protein binding cytoplasm microtubule organizing center cytoskeleton plasma membrane cilium protein transport membrane cell projection organization centriolar satellite BBSome ciliary transition zone ciliary basal body cell projection fat cell differentiation ciliary membrane cilium assembly protein localization to cilium uc009oor.1 uc009oor.2 
ENSMUST00000039803.7 Ubac2 ENSMUST00000039803.7 ubiquitin associated domain containing 2 (from RefSeq NM_026861.2) ENSMUST00000039803.1 ENSMUST00000039803.2 ENSMUST00000039803.3 ENSMUST00000039803.4 ENSMUST00000039803.5 ENSMUST00000039803.6 NM_026861 Phgdhl1 Q3TWC0 Q8R1K1 UBAC2_MOUSE uc007vao.1 uc007vao.2 uc007vao.3 Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (By similarity). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin- mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). Interacts with LMBR1L, FAF2, AMFR and VCP. Endoplasmic reticulum membrane ; Multi-pass membrane protein endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane protein localization to endoplasmic reticulum negative regulation of retrograde protein transport, ER to cytosol uc007vao.1 uc007vao.2 uc007vao.3 
ENSMUST00000039812.16 Zmym5 ENSMUST00000039812.16 zinc finger, MYM-type 5, transcript variant 2 (from RefSeq NM_001253752.1) ENSMUST00000039812.1 ENSMUST00000039812.10 ENSMUST00000039812.11 ENSMUST00000039812.12 ENSMUST00000039812.13 ENSMUST00000039812.14 ENSMUST00000039812.15 ENSMUST00000039812.2 ENSMUST00000039812.3 ENSMUST00000039812.4 ENSMUST00000039812.5 ENSMUST00000039812.6 ENSMUST00000039812.7 ENSMUST00000039812.8 ENSMUST00000039812.9 NM_001253752 Q3U2E2 Q8R1W3 ZMYM5_MOUSE uc007ucn.1 uc007ucn.2 uc007ucn.3 Functions as a transcriptional regulator. Interacts (via N-terminal 120 amino acid region) with ETV5 (via C-terminal). Nucleus Sequence=BC023007; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence=; RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription from RNA polymerase II promoter zinc ion binding regulation of cell morphogenesis metal ion binding uc007ucn.1 uc007ucn.2 uc007ucn.3 
ENSMUST00000039818.10 Aldh4a1 ENSMUST00000039818.10 aldehyde dehydrogenase 4 family, member A1 (from RefSeq NM_175438.4) AL4A1_MOUSE B1AXW8 ENSMUST00000039818.1 ENSMUST00000039818.2 ENSMUST00000039818.3 ENSMUST00000039818.4 ENSMUST00000039818.5 ENSMUST00000039818.6 ENSMUST00000039818.7 ENSMUST00000039818.8 ENSMUST00000039818.9 NM_175438 Q7TND0 Q8BXM3 Q8CHT0 Q8R0N1 Q8R1S2 uc012dnu.1 uc012dnu.2 uc012dnu.3 Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). Reaction=H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L- glutamate + NADH; Xref=Rhea:RHEA:30235, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58066; EC=1.2.1.88; Amino-acid degradation; L-proline degradation into L- glutamate; L-glutamate from L-proline: step 2/2. Homodimer. Mitochondrion matrix Acetylation of Lys-98, Lys-113 and Lys-401 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the aldehyde dehydrogenase family. 1-pyrroline-5-carboxylate dehydrogenase activity aldehyde dehydrogenase (NAD) activity mitochondrion mitochondrial matrix proline metabolic process proline catabolic process to glutamate oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor identical protein binding oxidation-reduction process uc012dnu.1 uc012dnu.2 uc012dnu.3 
ENSMUST00000039840.15 Enpp6 ENSMUST00000039840.15 ectonucleotide pyrophosphatase/phosphodiesterase 6 (from RefSeq NM_177304.4) ENPP6_MOUSE ENSMUST00000039840.1 ENSMUST00000039840.10 ENSMUST00000039840.11 ENSMUST00000039840.12 ENSMUST00000039840.13 ENSMUST00000039840.14 ENSMUST00000039840.2 ENSMUST00000039840.3 ENSMUST00000039840.4 ENSMUST00000039840.5 ENSMUST00000039840.6 ENSMUST00000039840.7 ENSMUST00000039840.8 ENSMUST00000039840.9 Enpp6 NM_177304 Q4VAH5 Q8BGN3 uc009lqr.1 uc009lqr.2 uc009lqr.3 This gene encodes a member of the nucleotide pyrophosphatase/phosphodiesterase family of enzymes that play an important role in regulating extracellular nucleotide metabolism. The encoded preproprotein undergoes proteolytic processing to generate a glycosylphosphatidylinositol (GPI)-anchored membrane protein that hydrolyzes choline-containing lysophospholipids such as glycerophosphocholine. Mice lacking the encoded protein develop fatty liver and myelin sheath abnormalities. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK046797.1, AK046881.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:15788404, PubMed:26888014). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids (PubMed:15788404). In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids (PubMed:15788404). Reaction=H2O + sn-glycerol 3-phosphocholine = glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:19545, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:17754, ChEBI:CHEBI:295975; EC=3.1.4.38; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19546; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:44720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58168, ChEBI:CHEBI:64683, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44721; Evidence=; Reaction=1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn- glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:36083, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15850, ChEBI:CHEBI:30909, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36084; Evidence=; Reaction=1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl- sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41127, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74966, ChEBI:CHEBI:75529, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41128; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:75542, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41120; Evidence=; Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41003, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:34071, ChEBI:CHEBI:74344, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41004; Evidence=; Reaction=1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1- tetradecanoyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:40999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64489, ChEBI:CHEBI:75536, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41000; Evidence=; Reaction=H2O + sphing-4-enine-phosphocholine = H(+) + phosphocholine + sphing-4-enine; Xref=Rhea:RHEA:41095, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57756, ChEBI:CHEBI:58906, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41096; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z- octadecenoyl)-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41091, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:75757, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41092; Evidence=; Reaction=1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41115, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28733, ChEBI:CHEBI:75561, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41116; Evidence=; Reaction=glycero-2-phosphocholine + H2O = glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:61684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:144950, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61685; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Inhibited by EDTA and EGTA in vitro. Homodimer; disulfide-linked (PubMed:26888014). Homotetramer (PubMed:26888014). Cell membrane ; Lipid-anchor, GPI- anchor Predominantly expressed in kidney with a lesser expression in brain and heart (PubMed:15788404, PubMed:26888014). In the brain and spinal cord, mainly expressed in the white matter. In oligodendrocytes, is predominantly detected in the myelin sheath. In the kidney, is predominantly expressed in the luminal side of the renal tubule in the cortex and in the proximal renal tubules. It is expressed in liver sinusoidal endothelial cells (PubMed:26888014). At postnatal day 2 (P2) and P4, is detected in immature oligodendrocytes, where it was predominantly found both in the processes and cell bodies. In contrast, at P12 and P14, it is found mainly in myelin sheaths. Enpp6 knockout mice give birth according to the Mendelian rule and are apparently normal. Mice exhibit mild symptoms of fatty liver and are more susceptible to a choline-deficient diet and exhibit severe fatty liver phenotypes at the early stage. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. catalytic activity extracellular region plasma membrane lipid metabolic process phosphoric diester hydrolase activity glycerophosphodiester phosphodiesterase activity membrane lipid catabolic process hydrolase activity choline metabolic process anchored component of membrane glycerophosphocholine cholinephosphodiesterase activity uc009lqr.1 uc009lqr.2 uc009lqr.3 
ENSMUST00000039861.7 Cd33 ENSMUST00000039861.7 Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (By similarity). Preferentially binds sialic acid to the short O-linked glycans of certain mucins (PubMed:12773563). (from UniProt Q63994) A2RT59 AK046303 CD33_MOUSE ENSMUST00000039861.1 ENSMUST00000039861.2 ENSMUST00000039861.3 ENSMUST00000039861.4 ENSMUST00000039861.5 ENSMUST00000039861.6 Q63994 Q63997 Siglec3 uc291pak.1 uc291pak.2 Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (By similarity). Preferentially binds sialic acid to the short O-linked glycans of certain mucins (PubMed:12773563). Homodimer; disulfide-linked. Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. Interacts with C1QA (via C- terminus); this interaction activates CD33 inhibitory motifs. Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=33-B; IsoId=Q63994-1; Sequence=Displayed; Name=33-A; IsoId=Q63994-2; Sequence=VSP_002534; Expressed on myeloid precursors in the bone marrow. In the peripheral blood, mostly expressed on granulocytes. Glycosylated. Phosphorylation is involved in binding to PTPN6 and PTPN11. CD33-deficient mice are viable and fertile in a pathogen-free environment without any obvious deficiency in overall organ development and growth. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Name=Functional Glycomics Gateway - Glycan Binding; Note=Siglec-3; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Itlect_195"; plasma membrane cell adhesion external side of plasma membrane membrane integral component of membrane carbohydrate binding uc291pak.1 uc291pak.2 
ENSMUST00000039862.11 Zp3r ENSMUST00000039862.11 zona pellucida 3 receptor, transcript variant 2 (from RefSeq NM_009581.3) ENSMUST00000039862.1 ENSMUST00000039862.10 ENSMUST00000039862.2 ENSMUST00000039862.3 ENSMUST00000039862.4 ENSMUST00000039862.5 ENSMUST00000039862.6 ENSMUST00000039862.7 ENSMUST00000039862.8 ENSMUST00000039862.9 G3X970 G3X970_MOUSE NM_009581 Zp3r uc007cmb.1 uc007cmb.2 uc007cmb.3 uc007cmb.4 Lacks conserved residue(s) required for the propagation of feature annotation. uc007cmb.1 uc007cmb.2 uc007cmb.3 uc007cmb.4 
ENSMUST00000039867.10 Zbtb41 ENSMUST00000039867.10 zinc finger and BTB domain containing 41, transcript variant 2 (from RefSeq NM_172643.6) A2A706 ENSMUST00000039867.1 ENSMUST00000039867.2 ENSMUST00000039867.3 ENSMUST00000039867.4 ENSMUST00000039867.5 ENSMUST00000039867.6 ENSMUST00000039867.7 ENSMUST00000039867.8 ENSMUST00000039867.9 NM_172643 Q811F1 Q8BI96 Q8BV67 Q8BYV8 ZBT41_MOUSE uc007cwg.1 uc007cwg.2 uc007cwg.3 uc007cwg.4 May be involved in transcriptional regulation. Nucleus Sequence=BAC29469.1; Type=Frameshift; Evidence=; Sequence=BAC37731.1; Type=Frameshift; Evidence=; Sequence=BAE37287.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc007cwg.1 uc007cwg.2 uc007cwg.3 uc007cwg.4 
ENSMUST00000039887.4 Pof1b ENSMUST00000039887.4 premature ovarian failure 1B (from RefSeq NM_181579.1) A2ANY1 ENSMUST00000039887.1 ENSMUST00000039887.2 ENSMUST00000039887.3 NM_181579 POF1B_MOUSE Q8C3A2 Q8K4L4 Q8R4R8 uc009udm.1 uc009udm.2 uc009udm.3 Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development (By similarity). Interacts with nonmuscle actin. Cell junction, tight junction Expression absent in adult ovary. Expressed in ovary between 16.5 dpc and P5. It is uncertain whether Met-1 or Met-2 is the initiator. The first methionine is not conserved among other organisms, but rat. It could be rodent-specific. epithelial cell morphogenesis actin binding actin filament adherens junction bicellular tight junction actin filament organization actin cytoskeleton organization cell junction desmosome actin filament binding bicellular tight junction assembly uc009udm.1 uc009udm.2 uc009udm.3 
ENSMUST00000039894.13 Tbce ENSMUST00000039894.13 tubulin-specific chaperone E, transcript variant 1 (from RefSeq NM_178337.3) ENSMUST00000039894.1 ENSMUST00000039894.10 ENSMUST00000039894.11 ENSMUST00000039894.12 ENSMUST00000039894.2 ENSMUST00000039894.3 ENSMUST00000039894.4 ENSMUST00000039894.5 ENSMUST00000039894.6 ENSMUST00000039894.7 ENSMUST00000039894.8 ENSMUST00000039894.9 NM_178337 Q8CIV8 TBCE_MOUSE uc007pmq.1 uc007pmq.2 uc007pmq.3 uc007pmq.4 This gene encodes a tubulin binding cofactor that participates in microtubule dynamics. A mouse model of progressive motor neuropathy (pmn) was discovered to harbor a single amino acid deletion in this gene. Mice that are homozygous for pmn allele exhibit progressive atrophy and premature death due to respiratory failure. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]. Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation (PubMed:12389029, PubMed:17184771). Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network (By similarity). Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers. Interacts with TBCD (By similarity). Cytoplasm Cytoplasm, cytoskeleton Ubiquitously expressed. Belongs to the TBCE family. microtubule cytoskeleton organization cytoplasm cytoskeleton protein folding tubulin complex assembly post-chaperonin tubulin folding pathway mitotic spindle organization axonogenesis adult locomotory behavior post-embryonic development muscle atrophy alpha-tubulin binding developmental growth peripheral nervous system neuron axonogenesis unfolded protein binding uc007pmq.1 uc007pmq.2 uc007pmq.3 uc007pmq.4 
ENSMUST00000039900.4 Prorsd1 ENSMUST00000039900.4 prolyl-tRNA synthetase domain containing 1, transcript variant 2 (from RefSeq NM_026465.3) ENSMUST00000039900.1 ENSMUST00000039900.2 ENSMUST00000039900.3 NM_026465 PRXD1_MOUSE Prdxdd1 Q8BFX7 Q9D820 uc007igz.1 uc007igz.2 uc007igz.3 uc007igz.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D820-1; Sequence=Displayed; Name=2; IsoId=Q9D820-2; Sequence=VSP_032962; Belongs to the PRORSD1 family. Sequence=CAI36003.2; Type=Erroneous gene model prediction; Evidence=; aminoacyl-tRNA editing activity molecular_function cellular_component biological_process uc007igz.1 uc007igz.2 uc007igz.3 uc007igz.4 
ENSMUST00000039913.9 Tigar ENSMUST00000039913.9 Trp53 induced glycolysis regulatory phosphatase (from RefSeq NM_177003.5) ENSMUST00000039913.1 ENSMUST00000039913.2 ENSMUST00000039913.3 ENSMUST00000039913.4 ENSMUST00000039913.5 ENSMUST00000039913.6 ENSMUST00000039913.7 ENSMUST00000039913.8 NM_177003 Q8BZA9 TIGAR_MOUSE Tigar uc009dvq.1 uc009dvq.2 uc009dvq.3 uc009dvq.4 Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (By similarity). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:23726973). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:23726973). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (By similarity). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3 (PubMed:22044588). Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (PubMed:22044588). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (PubMed:24872551). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner. Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (By similarity). Involved in intestinal tumor progression (PubMed:23726973). Reaction=beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate; Xref=Rhea:RHEA:17289, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634, ChEBI:CHEBI:58579; EC=3.1.3.46; Evidence=; Interacts with HK2; the interaction increases hexokinase HK2 activity in a hypoxia- and HIF1A-dependent manner, resulting in the regulation of mitochondrial membrane potential, thus increasing NADPH production and decreasing intracellular ROS levels. Cytoplasm Nucleus Mitochondrion Note=Translocated to the mitochondria during hypoxia in a HIF1A-dependent manner. Colocalizes with HK2 in the mitochondria during hypoxia. Translocated to the nucleus during hypoxia and/or genome stress-induced DNA damage responses in cancer cells (By similarity). Translocation to the mitochondria is enhanced in ischemic cortex after reperfusion and/or during oxygen and glucose deprivation (OGD)/reoxygenation insult in primary neurons (PubMed:24872551). Expressed in olfactory bulb, cerebellum, and cortex (PubMed:24872551). Expressed in neurons and astrocytes (PubMed:24872551) (at protein level). Expressed in intestinal crypt (PubMed:23726973). Up-regulated by hypoxia in cardiac myocytes in a p53/TP53- dependent manner (PubMed:20935145). Up-regulated in ischemic cortex after reperfusion in a p53/TP5-independent manner (PubMed:24872551). Up-regulated in primary neurons by oxygen and glucose deprivation (OGD)/reoxygenation insult in a p53/TP5-independent manner (at protein level) (PubMed:24872551). Up-regulated in ischemic myocardium in a p53/TP5-dependent manner (PubMed:22044588). Up-regulated in small intestine after gamma irradiation damage (PubMed:23726973). Mice are viable and fertile and show no obvious developmental defects (PubMed:23726973). Following intestine ablation by gamma irradiation, adult mice display a reduction in the size and number of proliferating intestinal crypts and an increase in cell death (PubMed:23726973). Mice display reduced intestinal tumor progression compared to wild-type mice (PubMed:23726973). In response to ischemic myocardium injury, display an increase in the ability to stimulate myocyte mitophagy in ischemic border zones through a ROS-induced and BNIP3 activation dependent manner leading to a reduction of defective mitochondria and myocyte cell death, and hence a better recovery of cardiac function (PubMed:22044588). Belongs to the phosphoglycerate mutase family. Not expected to have any kinase activity. response to ischemia catalytic activity bisphosphoglycerate 2-phosphatase activity fructose-2,6-bisphosphate 2-phosphatase activity nucleus cytoplasm mitochondrion mitochondrial outer membrane cytosol fructose 2,6-bisphosphate metabolic process autophagy apoptotic process cellular response to DNA damage stimulus response to xenobiotic stimulus response to gamma radiation positive regulation of cardiac muscle cell apoptotic process dephosphorylation hydrolase activity fructose 1,6-bisphosphate metabolic process negative regulation of kinase activity negative regulation of programmed cell death regulation of pentose-phosphate shunt positive regulation of DNA repair negative regulation of glycolytic process intestinal epithelial cell development cellular response to cobalt ion cellular response to hypoxia negative regulation of neuron death negative regulation of macromitophagy regulation of response to DNA damage checkpoint signaling positive regulation of hexokinase activity negative regulation of glucose catabolic process to lactate via pyruvate negative regulation of reactive oxygen species metabolic process uc009dvq.1 uc009dvq.2 uc009dvq.3 uc009dvq.4 
ENSMUST00000039922.13 Sufu ENSMUST00000039922.13 SUFU negative regulator of hedgehog signaling, transcript variant 2 (from RefSeq NM_001025391.2) ENSMUST00000039922.1 ENSMUST00000039922.10 ENSMUST00000039922.11 ENSMUST00000039922.12 ENSMUST00000039922.2 ENSMUST00000039922.3 ENSMUST00000039922.4 ENSMUST00000039922.5 ENSMUST00000039922.6 ENSMUST00000039922.7 ENSMUST00000039922.8 ENSMUST00000039922.9 NM_001025391 Q8C8B4 Q99JG0 Q9D521 Q9JLU1 Q9Z0P7 SUFU_MOUSE Sufu uc008htq.1 uc008htq.2 uc008htq.3 Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:16155214, PubMed:16459298). Down-regulates GLI1- mediated transactivation of target genes (PubMed:11960000). Part of a corepressor complex that acts on DNA-bound GLI1 (PubMed:11960000). May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (By similarity). Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10531011, PubMed:16459298). Negative regulator of beta-catenin signaling (PubMed:11477086). Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL) (PubMed:10531011, PubMed:20360384). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state (PubMed:10531011, PubMed:20360384). Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R (PubMed:10531011, PubMed:20360384). When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A) (PubMed:10531011, PubMed:20360384). Required for normal embryonic development (PubMed:16155214, PubMed:16459298). Required for the proper formation of hair follicles and the control of epidermal differentiation (PubMed:16155214, PubMed:16459298, PubMed:23034632). May form homodimers (By similarity). Interacts with ULK3; inactivating the protein kinase activity of ULK3. Interacts with RAB23 (By similarity). Part of a DNA-bound corepressor complex containing SAP18, GLI1 and SIN3 (PubMed:11960000). Part of a complex containing CTNNB1 (PubMed:11477086). Binds BTRC, GLI2, GLI3, SAP18 and STK36 (PubMed:20360384, PubMed:23034632). Binds both free and DNA-bound GLI1 (PubMed:10531011). Interacts with KIF7 (PubMed:19592253). Interacts with GLI3FL and this interaction regulates the formation of either repressor or activator forms of GLI3 (PubMed:20360384). Its association with GLI3FL is regulated by Hh signaling and dissociation of the SUFU- GLI3 interaction requires the presence of the ciliary motor KIF3A (PubMed:20360384). Q9Z0P7; P16110: Lgals3; NbExp=5; IntAct=EBI-3508336, EBI-3508325; Q9Z0P7; O88907: Pias1; NbExp=3; IntAct=EBI-3508336, EBI-3508327; Q9Z0P7; P50636: Rnf19a; NbExp=3; IntAct=EBI-3508336, EBI-3508340; Q9Z0P7; O55128: Sap18; NbExp=6; IntAct=EBI-3508336, EBI-3508332; Cytoplasm cleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Z0P7-1; Sequence=Displayed; Name=2; IsoId=Q9Z0P7-2; Sequence=VSP_013281, VSP_013282; Name=3; IsoId=Q9Z0P7-3; Sequence=VSP_013282, VSP_013283; Name=4; Synonyms=SU(FU)-XL; IsoId=Q9Z0P7-4; Sequence=VSP_013282; Widely expressed in adult and fetal tissues. Polyubiquitinated at Lys-257 by the SCF(FBXL17) complex, leading to its subsequent degradation and allowing the release of GLI1 for proper hedgehog/smoothened signal transduction. Ubiquitination is impaired by phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353. Phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353 prevents ubiquitination by the SCF(FBXL17) complex. Complete embryonic lethality at about 10.5 dpc due to defects in neural tube closure, abnormal somites and abnormal heart looping (PubMed:16155214, PubMed:16459298). Heterozygous mice are born at the expected Mendelian rate and are fertile. After 1.5 years, they develop a skin phenotype characterized by ventral alopecia, increased pigmentation, with papules and nodules on paws and tail (PubMed:16459298). Belongs to the SUFU family. negative regulation of transcription from RNA polymerase II promoter neural tube closure heart looping ventricular septum development protein binding nucleus cytoplasm cytosol cilium multicellular organism development determination of left/right symmetry beta-catenin binding transcription factor binding protein kinase binding spinal cord dorsal/ventral patterning smoothened signaling pathway involved in ventral spinal cord interneuron specification smoothened signaling pathway involved in spinal cord motor neuron cell fate specification aorta development cytoplasmic sequestering of transcription factor negative regulation of sequence-specific DNA binding transcription factor activity skin development negative regulation of smoothened signaling pathway coronary vasculature development negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc008htq.1 uc008htq.2 uc008htq.3 
ENSMUST00000039925.8 Upb1 ENSMUST00000039925.8 ureidopropionase, beta (from RefSeq NM_133995.4) BUP1_MOUSE ENSMUST00000039925.1 ENSMUST00000039925.2 ENSMUST00000039925.3 ENSMUST00000039925.4 ENSMUST00000039925.5 ENSMUST00000039925.6 ENSMUST00000039925.7 NM_133995 Q8R1K8 Q8VC97 uc007fqj.1 uc007fqj.2 uc007fqj.3 This gene encodes an enzyme that catalyzes the conversion of N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid or beta-alanine. Mutations in the related gene in human have been associated with beta-ureidopropionase deficiency. [provided by RefSeq, Dec 2013]. ##Evidence-Data-START## Transcript exon combination :: AK149480.1, AK149373.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Catalyzes a late step in pyrimidine degradation. Converts N- carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta- aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide. Reaction=3-(carbamoylamino)propanoate + 2 H(+) + H2O = beta-alanine + CO2 + NH4(+); Xref=Rhea:RHEA:11184, ChEBI:CHEBI:11892, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:28938, ChEBI:CHEBI:57966; EC=3.5.1.6; Evidence=; Reaction=3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O = (R)-3- amino-2-methylpropanoate + CO2 + NH4(+); Xref=Rhea:RHEA:37339, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:28938, ChEBI:CHEBI:57731, ChEBI:CHEBI:74414; EC=3.5.1.6; Evidence=; Amino-acid biosynthesis; beta-alanine biosynthesis. Homodimer, homotetramer, homooctamer; can also form higher homooligomers. Cytoplasm Belongs to the carbon-nitrogen hydrolase superfamily. BUP family. liver development catalytic activity beta-ureidopropionase activity cytoplasm nitrogen compound metabolic process metabolic process zinc ion binding hydrolase activity beta-alanine metabolic process beta-alanine biosynthetic process beta-alanine biosynthetic process via 3-ureidopropionate protein homodimerization activity pyrimidine nucleoside catabolic process protein homooligomerization protein homotetramerization uc007fqj.1 uc007fqj.2 uc007fqj.3 
ENSMUST00000039926.10 Dusp8 ENSMUST00000039926.10 dual specificity phosphatase 8 (from RefSeq NM_008748.3) DUS8_MOUSE ENSMUST00000039926.1 ENSMUST00000039926.2 ENSMUST00000039926.3 ENSMUST00000039926.4 ENSMUST00000039926.5 ENSMUST00000039926.6 ENSMUST00000039926.7 ENSMUST00000039926.8 ENSMUST00000039926.9 NM_008748 Nttp1 O09112 uc009kmo.1 uc009kmo.2 uc009kmo.3 uc009kmo.4 Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation (PubMed:7561881). Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues (Probable). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Monomer. Cytoplasm Nucleus Expressed predominantly in brain and lung. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. inactivation of MAPK activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity peptidyl-tyrosine dephosphorylation uc009kmo.1 uc009kmo.2 uc009kmo.3 uc009kmo.4 
ENSMUST00000039928.7 Plekhh1 ENSMUST00000039928.7 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 (from RefSeq NM_181073.3) ENSMUST00000039928.1 ENSMUST00000039928.2 ENSMUST00000039928.3 ENSMUST00000039928.4 ENSMUST00000039928.5 ENSMUST00000039928.6 Kiaa1200 NM_181073 PKHH1_MOUSE Q3UPN4 Q80TI1 Q8BWF3 Q8K334 Q99JL2 uc007nzr.1 uc007nzr.2 uc007nzr.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80TI1-1; Sequence=Displayed; Name=2; IsoId=Q80TI1-2; Sequence=VSP_029350, VSP_029351; Sequence=BAC65746.1; Type=Erroneous initiation; Evidence=; molecular_function cytoskeleton biological_process uc007nzr.1 uc007nzr.2 uc007nzr.3 
ENSMUST00000039949.5 Eme1 ENSMUST00000039949.5 essential meiotic structure-specific endonuclease 1, transcript variant 2 (from RefSeq NM_177752.5) EME1_MOUSE ENSMUST00000039949.1 ENSMUST00000039949.2 ENSMUST00000039949.3 ENSMUST00000039949.4 NM_177752 Q8BJW7 uc007kzf.1 uc007kzf.2 uc007kzf.3 Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; May self-associate (By similarity). Interacts with MUS81. Nucleus, nucleolus. Note=Recruited to regions of DNA damage in S-phase cells. Weakly expressed in brain, heart, kidney, liver, lung, muscle, skin, small intestine, spleen, stomach, testis and thymus (PubMed:14609959, PubMed:27010503). Expressed in bone marrow (PubMed:27010503). Also expressed in embryonic stem cells (ES cells) (PubMed:14609959). Belongs to the EME1/MMS4 family. resolution of meiotic recombination intermediates nuclear chromatin DNA binding nuclease activity endonuclease activity protein binding nucleus nuclear heterochromatin nucleolus DNA repair double-strand break repair DNA recombination cellular response to DNA damage stimulus hydrolase activity replication fork processing intra-S DNA damage checkpoint metal ion binding Holliday junction resolvase complex response to intra-S DNA damage checkpoint signaling nucleic acid phosphodiester bond hydrolysis crossover junction endodeoxyribonuclease activity uc007kzf.1 uc007kzf.2 uc007kzf.3 
ENSMUST00000039956.6 Slc41a2 ENSMUST00000039956.6 solute carrier family 41, member 2 (from RefSeq NM_177388.3) ENSMUST00000039956.1 ENSMUST00000039956.2 ENSMUST00000039956.3 ENSMUST00000039956.4 ENSMUST00000039956.5 NM_177388 Q8BYR8 S41A2_MOUSE uc007gkf.1 uc007gkf.2 uc007gkf.3 Acts as a plasma-membrane magnesium transporter (PubMed:15809054). Can also mediate the transport of other divalent metal cations in an order of Ba(2+) > Ni(2+) > Co(2+) > Fe(2+) > Mn(2+) (PubMed:15809054). Reaction=Mg(2+)(in) = Mg(2+)(out); Xref=Rhea:RHEA:29827, ChEBI:CHEBI:18420; Evidence=; Reaction=Mn(2+)(in) = Mn(2+)(out); Xref=Rhea:RHEA:28699, ChEBI:CHEBI:29035; Evidence=; Reaction=Co(2+)(in) = Co(2+)(out); Xref=Rhea:RHEA:28578, ChEBI:CHEBI:48828; Evidence=; Reaction=Ni(2+)(in) = Ni(2+)(out); Xref=Rhea:RHEA:29831, ChEBI:CHEBI:49786; Evidence=; Reaction=Fe(2+)(in) = Fe(2+)(out); Xref=Rhea:RHEA:28486, ChEBI:CHEBI:29033; Evidence=; Kinetic parameters: KM=0.34 mM for Mg(2+) ; Cell membrane ; Multi-pass membrane protein Belongs to the SLC41A transporter family. plasma membrane ion transport cation transport cation transmembrane transporter activity membrane integral component of membrane divalent metal ion transport divalent inorganic cation transmembrane transporter activity cation transmembrane transport uc007gkf.1 uc007gkf.2 uc007gkf.3 
ENSMUST00000039961.12 6820408C15Rik ENSMUST00000039961.12 RIKEN cDNA 6820408C15 gene, transcript variant 4 (from RefSeq NR_110368.1) 6820408C15Rik ENSMUST00000039961.1 ENSMUST00000039961.10 ENSMUST00000039961.11 ENSMUST00000039961.2 ENSMUST00000039961.3 ENSMUST00000039961.4 ENSMUST00000039961.5 ENSMUST00000039961.6 ENSMUST00000039961.7 ENSMUST00000039961.8 ENSMUST00000039961.9 NR_110368 Q8BJX2 Q8BJX2_MOUSE uc008nfk.1 uc008nfk.2 uc008nfk.3 molecular_function cellular_component biological_process uc008nfk.1 uc008nfk.2 uc008nfk.3 
ENSMUST00000039987.4 Tox ENSMUST00000039987.4 thymocyte selection-associated high mobility group box, transcript variant 1 (from RefSeq NM_145711.5) ENSMUST00000039987.1 ENSMUST00000039987.2 ENSMUST00000039987.3 NM_145711 Q66JW3 Q8BKH9 Q8BYQ5 Q8R4H0 TOX_MOUSE Tox uc008rxs.1 uc008rxs.2 uc008rxs.3 uc008rxs.4 Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (PubMed:25527292, PubMed:20818394, PubMed:11850626, PubMed:18195075, PubMed:15078895, PubMed:25915732). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA (PubMed:25527292, PubMed:31207603, PubMed:31207604). During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (PubMed:25527292). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches (PubMed:20818394). Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment (PubMed:11850626, PubMed:18195075). Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells (PubMed:18195075, PubMed:15078895). Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage (PubMed:25915732). Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (PubMed:20818394). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (PubMed:31207603, PubMed:31207604). Interacts with HBO1 complex composed at least of KAT7/HBO1, ING4, MEAF6, and JADE2; this complex is involved in histone acetylation. Interacts with DNMT1, LEO1, PAF1, SAP130 and SIN3A; these interactors regulate chromatin remodeling. Interacts with an array of proteins involved in RNA processing and translation and DNA replication. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q66JW3-1; Sequence=Displayed; Name=2; IsoId=Q66JW3-2; Sequence=VSP_019598, VSP_019599; Expressed in neurons of the subventricular zone (at protein level) (PubMed:25527292). Expressed in distinct subpopulations of thymocytes undergoing positive selection: double CD4-positive CD8- positive (DP) cells, CD4-positive CD8-low transitional cells and in single CD4-positive and CD8-positive cells (at protein level) (PubMed:11850626, PubMed:15078895). Expressed in ILC progenitors and mature ILC subsets: ILC1, ILC2 and ILC3 (at protein level) (PubMed:25915732). Expressed in lymphoid tissue-inducer cells and bone marrow NK cell subsets (PubMed:20818394). Abundant in thymus, liver and brain. Also detected in small intestine, spleen, stomach and testis (PubMed:11850626). Highly expressed in tumor-infiltrating CD8-positive T cells (at protein level) (PubMed:31207604). In the developing brain, expressed at embryonic day 9.5 dpc in neuroepithelium, displaying a rostral-high/ caudal-low and lateral-high/medial-low expression pattern. Abundant at 15.5 dpc in progenitors of the ventricular zone and differentiated neurons in the cortical plate. The lateral-medial gradient spread further in all cells of the ventricular zone of the lateral cortex by 18.5 dpc (at protein level). Transiently up-regulated during key developmental transition of immune cell subsets, likely marking a developmental checkpoint. Up- regulated during beta and positive selection of developing thymocytes, upon activation of pre-T cell receptor or T cell receptor in a calcineurin-dependent manner (PubMed:11850626, PubMed:15078895). Low expression is detected in precursor bone marrow NK cells, then is up- regulated in immature and mature bone marrow NK cells and later down- regulated in splenic mature NK cells (PubMed:20818394). (Microbial infection) Up-regulated in LCMV-specific CD8- positive T cells. Expressed at high levels in exhausted T cells during chronic infection. The HMG box is critical for TOX-dependent CD4-positive T cell lineage commitment. Mutant mice lack lymph nodes. The development of Peyer's patches is compromised, detectable only in some mutants. Peyer's patches are much smaller in size less abundant when compared to wild-type littermates. T cell lymphopenia is a hallmark phenotype of TOX-deficient mice. Belongs to the high motility group (HMG) box superfamily. DNA binding nucleus lymphocyte differentiation positive regulation of natural killer cell differentiation lymph node development Peyer's patch development uc008rxs.1 uc008rxs.2 uc008rxs.3 uc008rxs.4 
ENSMUST00000039990.6 P3h2 ENSMUST00000039990.6 prolyl 3-hydroxylase 2 (from RefSeq NM_173379.3) ENSMUST00000039990.1 ENSMUST00000039990.2 ENSMUST00000039990.3 ENSMUST00000039990.4 ENSMUST00000039990.5 Leprel1 NM_173379 P3H2_MOUSE P3h2 Q8C673 Q8CG71 uc007yuy.1 uc007yuy.2 uc007yuy.3 Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (PubMed:24368846, PubMed:25645914). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (PubMed:25645914). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that have proline instead of 4-hydroxyproline in the third position (By similarity). Reaction=2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]; Xref=Rhea:RHEA:22872, Rhea:RHEA- COMP:11676, Rhea:RHEA-COMP:11678, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50342, ChEBI:CHEBI:85428; EC=1.14.11.7; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Endoplasmic reticulum Sarcoplasmic reticulum Golgi apparatus Detected in kidney (PubMed:25645914). Detected on kidney tubular cells, pancreas acinar cells, Schwann cells of the peripheral nerve in the pinna, and in tunica adventitia, the smooth muscle layer of the aortic wall (at protein level) (PubMed:18487197). Detected in lung, skeletal muscle and kidney (PubMed:18487197). Detected in kidney glomeruli and in prehypertrophic regions of long bone from neonates (PubMed:25645914). In the eye, detected in the epithelial layer of the cornea and at lower levels in the sclera at the posterior end of the eye (PubMed:25645914). Contradictory results have been described and may be due to differences in the methods used for gene disruption (PubMed:24368846, PubMed:25645914). No visible phenotype, but decreased 3-hydroxyproline formation in collagen COL4A1 and COL1A1 (PubMed:25645914). Full embryonic lethality; the vast majority die before 8.5 dpc (PubMed:24368846). The embryos appear normal, but are surrounded by maternal platelet aggregates and blood clots that form at about 6.5 dpc, resulting in embryonic death (PubMed:24368846). Maternal platelet aggregation is triggered by interaction between maternal Gp6 and embryonic type IV collagen that lacks 3-hydroxyproline (PubMed:24368846). Likewise, pregnant females deficient for Gp6 and P3h2 that bear embryos deficient in P3h2 and heterozygous for Gp6 do not produce any live offspring (PubMed:24368846). In contrast, mutant mice deficient in Gp6 and P3h2 are born at the expected Mendelian rate and have no visible phenotype (PubMed:24368846). Belongs to the leprecan family. iron ion binding basement membrane endoplasmic reticulum Golgi apparatus negative regulation of cell proliferation oxidoreductase activity sarcoplasmic reticulum oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen peptidyl-proline hydroxylation procollagen-proline 3-dioxygenase activity L-ascorbic acid binding collagen metabolic process metal ion binding dioxygenase activity oxidation-reduction process uc007yuy.1 uc007yuy.2 uc007yuy.3 
ENSMUST00000039991.14 Slc12a9 ENSMUST00000039991.14 solute carrier family 12 (potassium/chloride transporters), member 9, transcript variant 2 (from RefSeq NM_031406.3) Cip1 E9QNN4 ENSMUST00000039991.1 ENSMUST00000039991.10 ENSMUST00000039991.11 ENSMUST00000039991.12 ENSMUST00000039991.13 ENSMUST00000039991.2 ENSMUST00000039991.3 ENSMUST00000039991.4 ENSMUST00000039991.5 ENSMUST00000039991.6 ENSMUST00000039991.7 ENSMUST00000039991.8 ENSMUST00000039991.9 NM_031406 Q99MR3 S12A9_MOUSE Slc12a8 uc009ace.1 uc009ace.2 uc009ace.3 uc009ace.4 May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function (By similarity). Interacts with SLC12A1. Cell membrane ; Multi-pass membrane protein Belongs to the SLC12A transporter family. plasma membrane ion transport cell volume homeostasis potassium:chloride symporter activity membrane integral component of membrane transmembrane transporter activity chloride ion homeostasis potassium ion homeostasis transmembrane transport chloride transmembrane transport potassium ion import across plasma membrane uc009ace.1 uc009ace.2 uc009ace.3 uc009ace.4 
ENSMUST00000040001.14 Galnt9 ENSMUST00000040001.14 polypeptide N-acetylgalactosaminyltransferase 9, transcript variant D (from RefSeq NR_185192.1) ENSMUST00000040001.1 ENSMUST00000040001.10 ENSMUST00000040001.11 ENSMUST00000040001.12 ENSMUST00000040001.13 ENSMUST00000040001.2 ENSMUST00000040001.3 ENSMUST00000040001.4 ENSMUST00000040001.5 ENSMUST00000040001.6 ENSMUST00000040001.7 ENSMUST00000040001.8 ENSMUST00000040001.9 G3X942 G3X942_MOUSE Galnt9 NR_185192 uc008yqz.1 uc008yqz.2 uc008yqz.3 uc008yqz.4 uc008yqz.5 Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Golgi membrane molecular_function Golgi apparatus protein glycosylation biological_process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups carbohydrate binding uc008yqz.1 uc008yqz.2 uc008yqz.3 uc008yqz.4 uc008yqz.5 
ENSMUST00000040002.4 Prr32 ENSMUST00000040002.4 proline rich 32 (from RefSeq NM_026841.2) A2AFE9 ENSMUST00000040002.1 ENSMUST00000040002.2 ENSMUST00000040002.3 NM_026841 PRR32_MOUSE Q9D0W7 uc009tbi.1 uc009tbi.2 uc009tbi.3 Sequence=BAB23262.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc009tbi.1 uc009tbi.2 uc009tbi.3 
ENSMUST00000040005.13 Alkbh3 ENSMUST00000040005.13 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase, transcript variant 20 (from RefSeq NR_184800.1) ALKB3_MOUSE Abh3 Alkbh3 ENSMUST00000040005.1 ENSMUST00000040005.10 ENSMUST00000040005.11 ENSMUST00000040005.12 ENSMUST00000040005.2 ENSMUST00000040005.3 ENSMUST00000040005.4 ENSMUST00000040005.5 ENSMUST00000040005.6 ENSMUST00000040005.7 ENSMUST00000040005.8 ENSMUST00000040005.9 NR_184800 Q8K1E6 uc008lgn.1 uc008lgn.2 uc008lgn.3 Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (By similarity). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PubMed:16174769). Has a strong preference for single-stranded DNA (PubMed:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Can repair exocyclic 3,N4-ethenocytosine adducs in single- stranded DNA. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha- ketoglutarate and iron (By similarity). Reaction=2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:49516, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12415, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=1.14.11.54; Evidence=; Reaction=2-oxoglutarate + a methylated nucleobase within DNA + O2 = a nucleobase within DNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:30299, Rhea:RHEA-COMP:12192, Rhea:RHEA-COMP:12193, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:32875, ChEBI:CHEBI:64428; EC=1.14.11.33; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30300; Evidence=; Reaction=2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single- stranded DNA + O2 = a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate; Xref=Rhea:RHEA:70447, Rhea:RHEA- COMP:17895, Rhea:RHEA-COMP:17896, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:90615, ChEBI:CHEBI:139096; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70448; Evidence=; Reaction=2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single- stranded DNA + O2 = a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate; Xref=Rhea:RHEA:70435, Rhea:RHEA- COMP:12846, Rhea:RHEA-COMP:17894, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:85452, ChEBI:CHEBI:139075; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70436; Evidence=; Reaction=2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single- stranded DNA + H2O + O2 = a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate; Xref=Rhea:RHEA:70471, Rhea:RHEA- COMP:12846, Rhea:RHEA-COMP:17906, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:34779, ChEBI:CHEBI:85452, ChEBI:CHEBI:189585; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70472; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Activated by ascorbate. Interacts with the ASCC complex composed of ASCC1, ASCC2 and ASCC3. Interacts directly with ASCC3, and is thereby recruited to the ASCC complex. Interacts with OTUD4; the interaction is direct. Interacts with USP7 and USP9X. Nucleus Cytoplasm Note=Colocalizes with ASCC2 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Predominantly localizes to the nucleus. Detected in testis, kidney, liver and heart. Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination. OTUD4 promotes USP7 and USP9X-dependent deubiquitination of 'Lys-48'- polyubiquitinated ALKBH3 promoting the repair of alkylated DNA lesions. No visible phenotype. Belongs to the alkB family. nucleus nucleoplasm cytoplasm mitochondrion cytosol DNA repair DNA dealkylation involved in DNA repair cellular response to DNA damage stimulus ferrous iron binding cell proliferation oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors oxidative single-stranded DNA demethylation oxidative single-stranded RNA demethylation DNA-N1-methyladenine dioxygenase activity metal ion binding dioxygenase activity cytosine C-5 DNA demethylase activity oxidation-reduction process nucleic acid phosphodiester bond hydrolysis RNA N1-methyladenosine dioxygenase activity endonuclease activity exonuclease activity uc008lgn.1 uc008lgn.2 uc008lgn.3 
ENSMUST00000040008.4 Ube2r2 ENSMUST00000040008.4 ubiquitin-conjugating enzyme E2R 2 (from RefSeq NM_026275.4) Cdc34b ENSMUST00000040008.1 ENSMUST00000040008.2 ENSMUST00000040008.3 NM_026275 Q6ZWZ2 Q8BW18 Q8VDE5 UB2R2_MOUSE Ubc3b uc008sij.1 uc008sij.2 uc008sij.3 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence= Protein modification; protein ubiquitination. When phosphorylated, interacts with beta-TrCP (BTRC). Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding ubiquitin-protein transferase activity ATP binding protein monoubiquitination protein ubiquitination transferase activity ubiquitin conjugating enzyme activity protein K48-linked ubiquitination uc008sij.1 uc008sij.2 uc008sij.3 
ENSMUST00000040017.8 Mios ENSMUST00000040017.8 meiosis regulator for oocyte development (from RefSeq NM_145374.2) E9QM00 ENSMUST00000040017.1 ENSMUST00000040017.2 ENSMUST00000040017.3 ENSMUST00000040017.4 ENSMUST00000040017.5 ENSMUST00000040017.6 ENSMUST00000040017.7 MIOS_MOUSE Mios NM_145374 Q8VE19 uc009axk.1 uc009axk.2 uc009axk.3 uc009axk.4 uc009axk.5 As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:35022234). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (By similarity). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (By similarity). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (By similarity). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (By similarity). Within the GATOR2 complex, MIOS is required to prevent autoubiquitination of WDR24, the catalytic subunit of the complex (By similarity). The GATOR2 complex is required for brain myelination (PubMed:35022234). The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids. In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated. Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine. CASTOR1 and CASTOR2 convey leucine availability via direct interaction with MIOS. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids. Lysosome membrane Widely expressed (PubMed:35022234). In brain, expressed in neurons and glia (oligodendrocytes and astrocytes), with more abundance in neurons (PubMed:35022234). Embryonic lethality around 9 dpc (PubMed:35022234). Conditional deletion in neural stem cells specifically impairs the formation of myelinating oligodendrocytes, thus brain myelination, without effecting the formation of neurons and astrocytes (PubMed:35022234). Belongs to the WD repeat mio family. molecular_function nucleus nucleoplasm cytoplasm lysosome lysosomal membrane cytosol membrane cell junction positive regulation of TOR signaling cellular response to amino acid starvation cellular protein complex localization GATOR2 complex uc009axk.1 uc009axk.2 uc009axk.3 uc009axk.4 uc009axk.5 
ENSMUST00000040021.12 Ptpn23 ENSMUST00000040021.12 protein tyrosine phosphatase, non-receptor type 23 (from RefSeq NM_001081043.1) ENSMUST00000040021.1 ENSMUST00000040021.10 ENSMUST00000040021.11 ENSMUST00000040021.2 ENSMUST00000040021.3 ENSMUST00000040021.4 ENSMUST00000040021.5 ENSMUST00000040021.6 ENSMUST00000040021.7 ENSMUST00000040021.8 ENSMUST00000040021.9 Kiaa1471 NM_001081043 PTN23_MOUSE Q69ZJ0 Q6PB44 Q8R1Z5 Q923E6 uc009rty.1 uc009rty.2 uc009rty.3 Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B (By similarity). Q6PB44; Q8BR07: Bicd1; NbExp=7; IntAct=EBI-4284816, EBI-11569902; Q6PB44; O89100: Grap2; NbExp=3; IntAct=EBI-4284816, EBI-642151; Nucleus Cytoplasm Cytoplasmic vesicle Endosome Cytoplasm, cytoskeleton, cilium basal body Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PB44-1; Sequence=Displayed; Name=2; IsoId=Q6PB44-2; Sequence=VSP_014195; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. Sequence=BAD32456.1; Type=Erroneous initiation; Evidence=; phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding nucleus nucleoplasm cytoplasm endosome early endosome cytosol cytoskeleton cilium protein dephosphorylation negative regulation of epithelial cell migration protein transport dephosphorylation nuclear body hydrolase activity phosphatase activity protein kinase binding cell projection organization cytoplasmic vesicle endocytic recycling peptidyl-tyrosine dephosphorylation ciliary basal body cell projection ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway early endosome to late endosome transport cilium assembly positive regulation of Wnt protein secretion positive regulation of homophilic cell adhesion positive regulation of adherens junction organization positive regulation of early endosome to late endosome transport uc009rty.1 uc009rty.2 uc009rty.3 
ENSMUST00000040025.14 Tln2 ENSMUST00000040025.14 talin 2, transcript variant 2 (from RefSeq NM_001408298.1) E9PUM4 E9PUM4_MOUSE ENSMUST00000040025.1 ENSMUST00000040025.10 ENSMUST00000040025.11 ENSMUST00000040025.12 ENSMUST00000040025.13 ENSMUST00000040025.2 ENSMUST00000040025.3 ENSMUST00000040025.4 ENSMUST00000040025.5 ENSMUST00000040025.6 ENSMUST00000040025.7 ENSMUST00000040025.8 ENSMUST00000040025.9 NM_001408298 Tln2 uc012gwa.1 uc012gwa.2 uc012gwa.3 ruffle actin binding structural constituent of cytoskeleton cytoskeleton focal adhesion cytoskeletal anchoring at plasma membrane cell adhesion actin filament binding uc012gwa.1 uc012gwa.2 uc012gwa.3 
ENSMUST00000040042.11 C8g ENSMUST00000040042.11 complement component 8, gamma polypeptide, transcript variant 1 (from RefSeq NM_027062.3) CO8G_MOUSE ENSMUST00000040042.1 ENSMUST00000040042.10 ENSMUST00000040042.2 ENSMUST00000040042.3 ENSMUST00000040042.4 ENSMUST00000040042.5 ENSMUST00000040042.6 ENSMUST00000040042.7 ENSMUST00000040042.8 ENSMUST00000040042.9 NM_027062 Q8VCG4 uc008isi.1 uc008isi.2 uc008isi.3 uc008isi.4 This gene encodes a secreted protein that is a core component of the complement 8 (C8) complex. C8 is part of the membrane attack complex which participates in the innate immune response against bacterial pathogens. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]. C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol (By similarity). C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded (By similarity). Secreted. Belongs to the calycin superfamily. Lipocalin family. complement binding immune system process extracellular region membrane attack complex extracellular space complement activation, alternative pathway complement activation, classical pathway cytolysis retinol binding macromolecular complex binding innate immune response uc008isi.1 uc008isi.2 uc008isi.3 uc008isi.4 
ENSMUST00000040056.15 Ppfibp2 ENSMUST00000040056.15 PTPRF interacting protein, binding protein 2 (liprin beta 2), transcript variant 1 (from RefSeq NM_008905.3) ENSMUST00000040056.1 ENSMUST00000040056.10 ENSMUST00000040056.11 ENSMUST00000040056.12 ENSMUST00000040056.13 ENSMUST00000040056.14 ENSMUST00000040056.2 ENSMUST00000040056.3 ENSMUST00000040056.4 ENSMUST00000040056.5 ENSMUST00000040056.6 ENSMUST00000040056.7 ENSMUST00000040056.8 ENSMUST00000040056.9 G3X957 G3X957_MOUSE NM_008905 Ppfibp2 uc009jbe.1 uc009jbe.2 uc009jbe.3 uc009jbe.4 uc009jbe.5 Belongs to the liprin family. Liprin-beta subfamily. uc009jbe.1 uc009jbe.2 uc009jbe.3 uc009jbe.4 uc009jbe.5 
ENSMUST00000040059.9 Hyal3 ENSMUST00000040059.9 hyaluronoglucosaminidase 3 (from RefSeq NM_178020.3) B1AV95 ENSMUST00000040059.1 ENSMUST00000040059.2 ENSMUST00000040059.3 ENSMUST00000040059.4 ENSMUST00000040059.5 ENSMUST00000040059.6 ENSMUST00000040059.7 ENSMUST00000040059.8 HYAL3_MOUSE Hyl3 NM_178020 Q8VBX7 Q8VEI3 Q8VI77 uc009rmc.1 uc009rmc.2 uc009rmc.3 Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm (PubMed:20586096). Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage (PubMed:18653706). Has no hyaluronidase activity in embryonic fibroblasts in vitro (PubMed:18234732). Has no hyaluronidase activity in granulosa cells in vitro (PubMed:18653706). Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D- glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35; Evidence=; pH dependence: Optimum pH is 7. Higher activity at pH 4 than at pH 7 in sperm. ; Secreted Cell membrane Cytoplasmic vesicle, secretory vesicle, acrosome Endoplasmic reticulum Early endosome Note=Mostly present in low-density vesicles. Low levels in higher density vesicles of late endosomes and lysosomes. Localized in punctate cytoplasmic vesicles and in perinuclear structures, but does not colocalize with LAMP1 (PubMed:18234732). Localized on the plasma membrane over the acrosome and on the surface of the midpiece of the sperm tail (PubMed:20586096). Expressed in testis, epididymal tissue, epididymal luminal fluid (ELF), acrosome-intact (AI) sperm and caput (CAP), corpus (COR) and caudal (CAU) sperm. Higher expression in sperm than testis (at protein level) (PubMed:20586096). Liver, kidney, skin, brain, stomach and testis (PubMed:11929860). Expressed mainly in granulosa cells of the ovaries. Expressed in small and large antral follicles. Not present in theca or stroma cells (PubMed:18653706). Expressed in testis and liver (PubMed:18762256). Expressed in testis and CAP, COR, and CAU epididymis tissue (PubMed:20586096). Up-regulated expression in apoptotic granulosa cells and in atretic follicles of the ovaries (PubMed:18653706). N-glycosylated. No visible phenotype. Both male and female mice are viable. Skeletal features, joints, whole-body weights, organ weights, organ morphologies and the serum hyaluronic acid (HA) levels are normal. No evidence of glycosaminoglycan accumulation, including vacuolization, in tissues analyzed including liver, lung, kidney, spleen, skin, fat, testes and seminal vesicles at 12-14 months of age. No difference in tissue organization or connective tissue thickness. Only a subtle change in the alveolar structure and extracellular matrix thickness in lung tissue sections at 12-14 months of age. Lungs have larger alveoli and more areas of thickened interstitium. Lung tissues from 6 months old mice show more immature alveoli compared to wild-type (PubMed:18762256). Mice are fully fertile (PubMed:18762256, PubMed:20586096). Sperm show delayed cumulus penetration and reduced acrosomal exocytosis (PubMed:20586096). Belongs to the glycosyl hydrolase 56 family. ovarian follicle atresia acrosomal vesicle acrosomal membrane catalytic activity hyalurononglucosaminidase activity extracellular region lysosome endosome early endosome endoplasmic reticulum plasma membrane carbohydrate metabolic process inflammatory response cell adhesion single fertilization penetration of zona pellucida metabolic process response to virus membrane hydrolase activity hydrolase activity, acting on glycosyl bonds hyaluronan catabolic process cytoplasmic vesicle hyaluronoglucuronidase activity response to antibiotic viral entry into host cell cartilage development cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to UV-B sperm midpiece negative regulation of ovarian follicle development positive regulation of acrosomal vesicle exocytosis virus receptor activity uc009rmc.1 uc009rmc.2 uc009rmc.3 
ENSMUST00000040065.4 Tlr13 ENSMUST00000040065.4 toll-like receptor 13 (from RefSeq NM_205820.1) ENSMUST00000040065.1 ENSMUST00000040065.2 ENSMUST00000040065.3 NM_205820 Q148Y7 Q3TDS2 Q6R5N8 TLR13_MOUSE uc009ubn.1 uc009ubn.2 uc009ubn.3 Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences. Binds MYD88 via their respective TIR domains (By similarity). Interacts with UNC93B1. Q6R5N8; Q6R5N8: Tlr13; NbExp=4; IntAct=EBI-16173901, EBI-16173901; Endosome membrane ; Single-pass type I membrane protein The sequence 23S rRNA from clinical isolates of erythromycin-resistant S.aureus is methylated and is not recognized by Tlr13 anymore, suggesting a link between antibiotic resistance and evasion from Tlr13 recognition. 23S rRNA modifications generating resistance toward MLS antibiotics preventing recognition of bacteria from Tlr13. These data may also explain why Tlr13 is not conserved in human: human may instead possess a related rRNA-sensing pattern recognition receptor that has evolved to recognize species that can hide from Tlr13 owing to rRNA modifications (PubMed:22821982). Belongs to the Toll-like receptor family. In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity. Sequence=BAE41528.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; toll-like receptor signaling pathway immune system process MyD88-dependent toll-like receptor signaling pathway RNA binding protein binding cytoplasm endosome integral component of plasma membrane inflammatory response signal transduction response to virus endosome membrane membrane integral component of membrane rRNA binding toll-like receptor 13 signaling pathway identical protein binding protein homodimerization activity regulation of MAPK cascade innate immune response uc009ubn.1 uc009ubn.2 uc009ubn.3 
ENSMUST00000040084.10 Lhfpl1 ENSMUST00000040084.10 lipoma HMGIC fusion partner-like 1 (from RefSeq NM_178358.4) ENSMUST00000040084.1 ENSMUST00000040084.2 ENSMUST00000040084.3 ENSMUST00000040084.4 ENSMUST00000040084.5 ENSMUST00000040084.6 ENSMUST00000040084.7 ENSMUST00000040084.8 ENSMUST00000040084.9 LHPL1_MOUSE Lhfpl Lhfpl1 NM_178358 Q80SV1 uc009umz.1 uc009umz.2 uc009umz.3 Membrane ; Multi-pass membrane protein Widely expressed (PubMed:26964900). Strongly expressed in vagina and ovary. Weakly expressed in spleen, kidney, thymus, testis, brain, lung, intestine and uterus (PubMed:26964900). Belongs to the LHFP family. molecular_function cellular_component biological_process membrane integral component of membrane uc009umz.1 uc009umz.2 uc009umz.3 
ENSMUST00000040090.16 Nubpl ENSMUST00000040090.16 nucleotide binding protein-like (from RefSeq NM_029760.2) ENSMUST00000040090.1 ENSMUST00000040090.10 ENSMUST00000040090.11 ENSMUST00000040090.12 ENSMUST00000040090.13 ENSMUST00000040090.14 ENSMUST00000040090.15 ENSMUST00000040090.2 ENSMUST00000040090.3 ENSMUST00000040090.4 ENSMUST00000040090.5 ENSMUST00000040090.6 ENSMUST00000040090.7 ENSMUST00000040090.8 ENSMUST00000040090.9 NM_029760 NUBPL_MOUSE Q6P6K2 Q9CWD8 uc007nnh.1 uc007nnh.2 uc007nnh.3 uc007nnh.4 Iron-sulfur cluster transfer protein involved in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (By similarity). May deliver one or more Fe-S clusters to complex I subunits (By similarity). Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Mitochondrion Belongs to the Mrp/NBP35 ATP-binding proteins family. nucleotide binding ATP binding mitochondrion plasma membrane iron-sulfur cluster assembly mitochondrial respiratory chain complex I assembly metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding mitochondrion morphogenesis uc007nnh.1 uc007nnh.2 uc007nnh.3 uc007nnh.4 
ENSMUST00000040097.14 Palmd ENSMUST00000040097.14 palmdelphin (from RefSeq NM_023245.3) A0A0R4J0J0 A0A0R4J0J0_MOUSE ENSMUST00000040097.1 ENSMUST00000040097.10 ENSMUST00000040097.11 ENSMUST00000040097.12 ENSMUST00000040097.13 ENSMUST00000040097.2 ENSMUST00000040097.3 ENSMUST00000040097.4 ENSMUST00000040097.5 ENSMUST00000040097.6 ENSMUST00000040097.7 ENSMUST00000040097.8 ENSMUST00000040097.9 NM_023245 Palmd uc008rcx.1 uc008rcx.2 uc008rcx.3 Cell projection, dendritic spine Cytoplasm Belongs to the paralemmin family. regulation of cell shape membrane uc008rcx.1 uc008rcx.2 uc008rcx.3 
ENSMUST00000040104.5 Hand2 ENSMUST00000040104.5 heart and neural crest derivatives expressed 2 (from RefSeq NM_010402.4) Dhand ENSMUST00000040104.1 ENSMUST00000040104.2 ENSMUST00000040104.3 ENSMUST00000040104.4 HAND2_MOUSE Hed NM_010402 Q61039 Q61100 Thing2 uc009lss.1 uc009lss.2 uc009lss.3 uc009lss.4 Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior- posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG- 3'. Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND1 and HEY1, HEY2 and HEYL (hairy-related transcription factors). Q61039; Q64279: Hand1; NbExp=3; IntAct=EBI-81388, EBI-81361; Q61039; Q99N72: Mcf2; NbExp=3; IntAct=EBI-81388, EBI-641874; Q61039; P15806: Tcf3; NbExp=2; IntAct=EBI-81388, EBI-81370; Nucleus Heart and aorta. High extraembryonic expression is detected at 7.5 dpc in the maternally derived deciduum. Also detected along the yolk sac vessels during the process of remodeling at 9.5-10.0 dpc. Within the embryo, detected at 7.5 dpc in the lateral mesoderm including the precardiac mesoderm. On day 8.5 pc expressed throughout the straight heart tube. In the caudal region of the embryo, expressed in the lateral mesoderm at the level of separation of the somatic and splanchnic mesoderm. On day 9.5 pc expressed throughout the developing cardiovascular region, most abundant in the outflow tract and in the first and second aortic arch arteries, and in pharyngeal arches. As the heart loops, the expression becomes restricted to the conotruncus and future right ventricle (endocardium and myocardium). At 10.5 dpc, highly expressed in the branchial arches, as well as in the truncus arteriosus, aortic sac, and the vascular mesenchyme between the third and fourth aortic arch arteries, which later gives rise to vascular smooth muscle cells and to the mesenchyme of the pharyngeal arch. At 13.5 dpc, barely detectable in the heart, but apparent in the neural crest-derived sympathetic trunk and adrenal medulla, a pattern similar to that of HAND1. In the developing limbs, expression is detected in the posterior mesoderm of the buds at 9.5 dpc. It is then progressively down-regulated at the anterior of the limb buds so that a gradient expression along the anterior-posterior axis of the bud is established with higher expression at the posterior border. At later stages of limb development, expression is restricted to the posterior border of the zeugopod and to the posterior autopod. In the autopod, dynamic expression of HAND2 affects the interdigital regions, the lateral borders of the digits and eventually the developing ventral tendons. After 16 dpc, expression decreases throughout the embryo. Sequence=AAA86274.1; Type=Frameshift; Evidence=; Sequence=AAC52338.1; Type=Frameshift; Evidence=; nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis in utero embryonic development heart looping suckling behavior heart morphogenesis cardiac right ventricle formation cardiac neural crest cell migration involved in outflow tract morphogenesis regulation of secondary heart field cardioblast proliferation apoptotic process involved in heart morphogenesis DNA binding AT DNA binding protein binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated multicellular organism development heart development adult heart development transcription factor binding mesenchymal cell proliferation positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression negative regulation of cardiac muscle cell apoptotic process neural crest cell development cell differentiation macromolecular complex activating transcription factor binding regulation of tissue remodeling odontogenesis of dentin-containing tooth embryonic digit morphogenesis protein homodimerization activity negative regulation of apoptotic process negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding tongue development negative regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity sympathetic nervous system development thymus development peripheral nervous system neuron development palate development mesenchyme development cartilage morphogenesis coronary artery morphogenesis visceral serous pericardium development cardiac neural crest cell development involved in outflow tract morphogenesis cell proliferation involved in outflow tract morphogenesis determination of heart left/right asymmetry positive regulation of ERK1 and ERK2 cascade E-box binding positive regulation of p38MAPK cascade primary palate development positive regulation of transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis transcription regulatory region DNA binding uc009lss.1 uc009lss.2 uc009lss.3 uc009lss.4 
ENSMUST00000040106.9 Fam151b ENSMUST00000040106.9 family with sequence similarity 151, member B (from RefSeq NM_001163627.1) D3YUE4 ENSMUST00000040106.1 ENSMUST00000040106.2 ENSMUST00000040106.3 ENSMUST00000040106.4 ENSMUST00000040106.5 ENSMUST00000040106.6 ENSMUST00000040106.7 ENSMUST00000040106.8 F151B_MOUSE NM_001163627 uc007rkp.1 uc007rkp.2 uc007rkp.3 uc007rkp.4 Essential for survival of retinal photoreceptor cells. Mice show a degenerative retinal phenotype at week 15, characterized by patchy pigmentation of the retina. They have no photoreceptor function from eye opening. During development of the eye the correct number of cells are produced and the layers of the retina differentiate normally. However, after eye opening at P14, eyes exhibit signs of retinal stress and rapidly lose photoreceptor cells. Belongs to the FAM151 family. molecular_function cellular_component biological_process uc007rkp.1 uc007rkp.2 uc007rkp.3 uc007rkp.4 
ENSMUST00000040110.8 Chst11 ENSMUST00000040110.8 carbohydrate sulfotransferase 11 (from RefSeq NM_021439.3) CHSTB_MOUSE ENSMUST00000040110.1 ENSMUST00000040110.2 ENSMUST00000040110.3 ENSMUST00000040110.4 ENSMUST00000040110.5 ENSMUST00000040110.6 ENSMUST00000040110.7 NM_021439 Q9JJS2 Q9JME2 uc007gke.1 uc007gke.2 uc007gke.3 uc007gke.4 Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. Reaction=n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+); Xref=Rhea:RHEA:16101, Rhea:RHEA-COMP:9827, Rhea:RHEA-COMP:9829, ChEBI:CHEBI:15378, ChEBI:CHEBI:57652, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58422; EC=2.8.2.5; Evidence=; Golgi apparatus membrane ; Single- pass type II membrane protein Predominantly expressed in brain and kidney. Also expressed at weaker level in heart, spleen and lung. Expressed in developing chondrocytes. First expressed at day 9.75 of embryogenesis in the apical ectodermal ridge (AER) of the developing limb buds and at the edges of branchial arches 1 and 2. Also expressed in the ventral neural tube, notochord and sympathetic ganglia and the mesonephric tubules of the developing kidneys. In the heart, it is expressed in the myocardium of the atrium and in the endocardial cushions of both the developing inflow tract and the atrioventricular valves. At day 15, it is expressed in the cartilage of developing bones, in vertebrae and cartilage of the trachea as well as in the thymus. In the forelimb, it is expressed in all developing bones, but absent from developing joint regions and was down-regulated in chondrocytes beginning to undergo mineralization, such as in the center of the ulna. At day 15, no expression in the neural tube is observed. In the heart at day 15, it is still expressed in the atrial valve, the atrioventricular valves and in the myocardium of the atrium, while in the kidney, it is expressed in the collecting tubules as well as in Bowman capsule. Interestingly, the liver displays a punctate expression at day 15. Also expressed in tooth primordia, hair follicles and mammary glands. By BMP2, suggesting it is a target of BMP signaling. N-glycosylated; required for activity and stability. Belongs to the sulfotransferase 2 family. Golgi membrane N-acetylgalactosamine 4-O-sulfotransferase activity in utero embryonic development chondrocyte development Golgi apparatus carbohydrate metabolic process respiratory gaseous exchange sulfotransferase activity post-embryonic development membrane integral component of membrane carbohydrate biosynthetic process transferase activity proteoglycan biosynthetic process chondroitin sulfate metabolic process chondroitin sulfate biosynthetic process embryonic limb morphogenesis negative regulation of transforming growth factor beta receptor signaling pathway polysaccharide localization post-anal tail morphogenesis regulation of cell proliferation embryonic digit morphogenesis negative regulation of apoptotic process chondroitin 4-sulfotransferase activity developmental growth embryonic viscerocranium morphogenesis embryonic skeletal system morphogenesis N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity cartilage development uc007gke.1 uc007gke.2 uc007gke.3 uc007gke.4 
ENSMUST00000040117.15 Secisbp2 ENSMUST00000040117.15 SECIS binding protein 2, transcript variant 1 (from RefSeq NM_029279.2) ENSMUST00000040117.1 ENSMUST00000040117.10 ENSMUST00000040117.11 ENSMUST00000040117.12 ENSMUST00000040117.13 ENSMUST00000040117.14 ENSMUST00000040117.2 ENSMUST00000040117.3 ENSMUST00000040117.4 ENSMUST00000040117.5 ENSMUST00000040117.6 ENSMUST00000040117.7 ENSMUST00000040117.8 ENSMUST00000040117.9 NM_029279 Q3U1C4 Q3U1C4_MOUSE Secisbp2 uc007qml.1 uc007qml.2 uc007qml.3 uc007qml.4 The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in a similar gene in human have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. selenocysteine incorporation RNA binding mRNA 3'-UTR binding protein binding mitochondrion striatum development selenocysteine insertion sequence binding ribonucleoprotein complex binding neuron development positive regulation of selenocysteine incorporation ribonucleoprotein complex negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay uc007qml.1 uc007qml.2 uc007qml.3 uc007qml.4 
ENSMUST00000040128.12 Atp8b4 ENSMUST00000040128.12 ATPase, class I, type 8B, member 4, transcript variant 1 (from RefSeq NM_001359975.1) A2ANX3 A2ANX3_MOUSE Atp8b4 ENSMUST00000040128.1 ENSMUST00000040128.10 ENSMUST00000040128.11 ENSMUST00000040128.2 ENSMUST00000040128.3 ENSMUST00000040128.4 ENSMUST00000040128.5 ENSMUST00000040128.6 ENSMUST00000040128.7 ENSMUST00000040128.8 ENSMUST00000040128.9 NM_001359975 uc290adl.1 uc290adl.2 Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Membrane ulti-pass membrane protein Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. nucleotide binding magnesium ion binding ATP binding Golgi apparatus plasma membrane Golgi organization phospholipid transport membrane integral component of membrane phospholipid translocation uc290adl.1 uc290adl.2 
ENSMUST00000040131.13 Elf1 ENSMUST00000040131.13 E74 like ETS transcription factor 1, transcript variant 1 (from RefSeq NM_007920.5) ELF1_MOUSE ENSMUST00000040131.1 ENSMUST00000040131.10 ENSMUST00000040131.11 ENSMUST00000040131.12 ENSMUST00000040131.2 ENSMUST00000040131.3 ENSMUST00000040131.4 ENSMUST00000040131.5 ENSMUST00000040131.6 ENSMUST00000040131.7 ENSMUST00000040131.8 ENSMUST00000040131.9 NM_007920 Q60775 uc007utb.1 uc007utb.2 uc007utb.3 uc007utb.4 Transcription factor that activates the LYN and BLK promoters. Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes. Interacts with RUNX1. Interacts with SP1; the interaction is inhibited by glycosylation of SP1 (By similarity). Nucleus. Predominantly found in hematopoietic cells. Detected in other cell types such as fibroblasts. Belongs to the ETS family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding regulation of cytokine production DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell differentiation sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of T cell receptor signaling pathway uc007utb.1 uc007utb.2 uc007utb.3 uc007utb.4 
ENSMUST00000040134.8 Ndp ENSMUST00000040134.8 Norrie disease (pseudoglioma) (human) (from RefSeq NM_010883.3) ENSMUST00000040134.1 ENSMUST00000040134.2 ENSMUST00000040134.3 ENSMUST00000040134.4 ENSMUST00000040134.5 ENSMUST00000040134.6 ENSMUST00000040134.7 NDP_MOUSE NM_010883 Ndph P48744 Q5CZY6 uc009ssc.1 uc009ssc.2 uc009ssc.3 This gene encodes a secreted protein that acts a ligand for multiple different receptors and participates in both Wnt and Wnt-independant signalling. Its activity is important in vascular development of the eye and inner ear. Mutation of the related gene in humans causes Norrie syndrome. [provided by RefSeq, May 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC090623.1, X92397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. Homodimer; disulfide-linked (By similarity). Component of a complex, at least composed of TSPAN12, FZD4, LRP5/6 and norrin (NDP). Binds FZD4 with high affinity. Interacts with LRP6 (via Beta-propellers 1 and 2). Secreted Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina. placenta development frizzled binding cytokine activity extracellular region extracellular space cell surface Wnt signaling pathway extracellular matrix-cell signaling protein homodimerization activity positive regulation of transcription, DNA-templated positive regulation of sequence-specific DNA binding transcription factor activity retina vasculature morphogenesis in camera-type eye uc009ssc.1 uc009ssc.2 uc009ssc.3 
ENSMUST00000040135.9 Nup43 ENSMUST00000040135.9 nucleoporin 43 (from RefSeq NM_145706.2) E9QPN3 ENSMUST00000040135.1 ENSMUST00000040135.2 ENSMUST00000040135.3 ENSMUST00000040135.4 ENSMUST00000040135.5 ENSMUST00000040135.6 ENSMUST00000040135.7 ENSMUST00000040135.8 NM_145706 NUP43_MOUSE P59235 uc007eid.1 uc007eid.2 uc007eid.3 uc007eid.4 Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation (By similarity). Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13 (By similarity). Chromosome, centromere, kinetochore Nucleus, nuclear pore complex chromosome, centromeric region kinetochore condensed chromosome kinetochore molecular_function nucleus nuclear pore chromosome cell cycle chromosome segregation protein transport nuclear pore outer ring mRNA transport cell division uc007eid.1 uc007eid.2 uc007eid.3 uc007eid.4 
ENSMUST00000040151.9 Sapcd1 ENSMUST00000040151.9 suppressor APC domain containing 1, transcript variant 1 (from RefSeq NM_023893.4) B2RWH1 ENSMUST00000040151.1 ENSMUST00000040151.2 ENSMUST00000040151.3 ENSMUST00000040151.4 ENSMUST00000040151.5 ENSMUST00000040151.6 ENSMUST00000040151.7 ENSMUST00000040151.8 G7d NM_023893 Ng23 Q9CY86 Q9Z1Q7 SAPC1_MOUSE uc008cfb.1 uc008cfb.2 uc008cfb.3 uc008cfb.4 uc008cfb.5 uc008cfb.6 molecular_function cellular_component biological_process uc008cfb.1 uc008cfb.2 uc008cfb.3 uc008cfb.4 uc008cfb.5 uc008cfb.6 
ENSMUST00000040154.10 Cox6a1 ENSMUST00000040154.10 cytochrome c oxidase subunit 6A1 (from RefSeq NM_007748.5) Cox6a1 ENSMUST00000040154.1 ENSMUST00000040154.2 ENSMUST00000040154.3 ENSMUST00000040154.4 ENSMUST00000040154.5 ENSMUST00000040154.6 ENSMUST00000040154.7 ENSMUST00000040154.8 ENSMUST00000040154.9 NM_007748 Q9DCW5 Q9DCW5_MOUSE uc008zdt.1 uc008zdt.2 uc008zdt.3 uc008zdt.4 Energy metabolism; oxidative phosphorylation. Membrane ; Single- pass membrane protein Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the cytochrome c oxidase subunit 6A family. cytochrome-c oxidase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex IV membrane integral component of membrane electron transport chain hydrogen ion transmembrane transport uc008zdt.1 uc008zdt.2 uc008zdt.3 uc008zdt.4 
ENSMUST00000040159.6 C1galt1 ENSMUST00000040159.6 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 (from RefSeq NM_052993.3) C1GLT_MOUSE ENSMUST00000040159.1 ENSMUST00000040159.2 ENSMUST00000040159.3 ENSMUST00000040159.4 ENSMUST00000040159.5 NM_052993 Plt1 Q6P218 Q8R0Z7 Q9JJ06 uc009axg.1 uc009axg.2 uc009axg.3 uc009axg.4 Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development. Reaction=an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D- galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:15621, ChEBI:CHEBI:15378, ChEBI:CHEBI:28257, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:133470; EC=2.4.1.122; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Protein modification; protein glycosylation. Homodimer; disulfide-linked. Interacts with the C1GALT1C1 chaperone; required for galactosyltransferase activity (By similarity). Membrane; Single-pass type II membrane protein. Primarily expressed in endothelial, hematopoietic and epithelial cells during development. Mice develop brain hemorrhage that cause death at 14 dpc during development. They express the nonsialylated Tn antigen and brains form a chaotic microvascular network with distorted capillary lumens and defective association of endothelial cells with pericytes and extracellular matrix. Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. angiogenesis kidney development protein glycosylation protein O-linked glycosylation multicellular organism development galactosyltransferase activity membrane integral component of membrane glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity O-glycan processing O-glycan processing, core 1 transferase activity transferase activity, transferring glycosyl groups cell differentiation metal ion binding intestinal epithelial cell development uc009axg.1 uc009axg.2 uc009axg.3 uc009axg.4 
ENSMUST00000040161.5 Gpr33 ENSMUST00000040161.5 G protein-coupled receptor 33 (from RefSeq NM_008159.3) ENSMUST00000040161.1 ENSMUST00000040161.2 ENSMUST00000040161.3 ENSMUST00000040161.4 GPR33_MOUSE NM_008159 O88416 uc007nnf.1 uc007nnf.2 uc007nnf.3 Orphan receptor; could be a chemoattractant receptor. Cell membrane; Multi-pass membrane protein. Expressed predominantly in lung, spleen and testis. Belongs to the G-protein coupled receptor 1 family. complement receptor mediated signaling pathway G-protein coupled receptor activity plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane uc007nnf.1 uc007nnf.2 uc007nnf.3 
ENSMUST00000040162.3 Gdf5 ENSMUST00000040162.3 growth differentiation factor 5 (from RefSeq NM_008109.4) A2ARK2 Bmp14 Bp ENSMUST00000040162.1 ENSMUST00000040162.2 GDF5_MOUSE Gdf-5 NM_008109 P43027 uc012chg.1 uc012chg.2 uc012chg.3 uc012chg.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mice with a mutation in this gene exhibit enhanced tooth enamel formation. [provided by RefSeq, Aug 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U08337.1, AB259648.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (By similarity). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (By similarity). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (PubMed:24076600). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Homodimer; disulfide-linked (By similarity). Interacts with serine proteases, HTRA1 and HTRA3 (PubMed:15206957, PubMed:14973287). Following LPS binding, may form a complex with CXCR4, HSP90AA1 and HSPA8 (By similarity). Interacts with high affinity with NOG; inhibits chondrogenesis (By similarity). Interacts with high affinity with BMPR1B and lower affinity with BMPR1A; positively regulates chondrocyte differentiation and induces SMAD-dependent signaling. Interacts with FBN1 (via N-terminal domain) and FBN2 (By similarity). Secreted Cell membrane Induced over 300-fold in tibialis anterior muscles 3 days following denervation. High expression is maintained at least until 10 days after denervation. Note=Defects in Gdf5 are the cause of brachypodism (bp) which alters the length and numbers of bones in the limbs but spares the axial skeleton. Belongs to the TGF-beta family. receptor binding cytokine activity transforming growth factor beta receptor binding protein binding extracellular region extracellular space plasma membrane transmembrane receptor protein serine/threonine kinase signaling pathway growth factor activity response to mechanical stimulus positive regulation of pathway-restricted SMAD protein phosphorylation membrane embryonic limb morphogenesis BMP signaling pathway positive regulation of BMP signaling pathway negative regulation of chondrocyte differentiation positive regulation of chondrocyte differentiation forelimb morphogenesis hindlimb morphogenesis BMP binding regulation of multicellular organism growth identical protein binding regulation of apoptotic process regulation of MAPK cascade negative regulation of neuron apoptotic process ossification involved in bone remodeling positive regulation of neuron differentiation cell development negative regulation of epithelial cell proliferation cartilage development regulation of SMAD protein import into nucleus SMAD protein signal transduction chondroblast differentiation negative regulation of mesenchymal cell apoptotic process uc012chg.1 uc012chg.2 uc012chg.3 uc012chg.4 
ENSMUST00000040166.14 Susd1 ENSMUST00000040166.14 sushi domain containing 1 (from RefSeq NM_001163288.3) E9Q3H4 E9Q3H4_MOUSE ENSMUST00000040166.1 ENSMUST00000040166.10 ENSMUST00000040166.11 ENSMUST00000040166.12 ENSMUST00000040166.13 ENSMUST00000040166.2 ENSMUST00000040166.3 ENSMUST00000040166.4 ENSMUST00000040166.5 ENSMUST00000040166.6 ENSMUST00000040166.7 ENSMUST00000040166.8 ENSMUST00000040166.9 NM_001163288 Susd1 uc012dew.1 uc012dew.2 Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function calcium ion binding cellular_component biological_process membrane integral component of membrane uc012dew.1 uc012dew.2 
ENSMUST00000040167.11 Mat2b ENSMUST00000040167.11 methionine adenosyltransferase 2 non-catalytic beta subunit methionine, transcript variant 1 (from RefSeq NM_134017.2) ENSMUST00000040167.1 ENSMUST00000040167.10 ENSMUST00000040167.2 ENSMUST00000040167.3 ENSMUST00000040167.4 ENSMUST00000040167.5 ENSMUST00000040167.6 ENSMUST00000040167.7 ENSMUST00000040167.8 ENSMUST00000040167.9 MAT2B_MOUSE NM_134017 Q5NC89 Q76LX2 Q8BVX6 Q8BYT9 Q99LB6 uc007ilp.1 uc007ilp.2 uc007ilp.3 uc007ilp.4 Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro). Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99LB6-1; Sequence=Displayed; Name=2; IsoId=Q99LB6-2; Sequence=VSP_025541; Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily. Sequence=BAC29963.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=CAI25424.1; Type=Erroneous gene model prediction; Evidence=; nucleus mitochondrion S-adenosylmethionine biosynthetic process one-carbon metabolic process enzyme binding methionine adenosyltransferase complex methionine adenosyltransferase regulator activity regulation of catalytic activity uc007ilp.1 uc007ilp.2 uc007ilp.3 uc007ilp.4 
ENSMUST00000040177.8 Polr1has ENSMUST00000040177.8 RNA polymerase I subunit H, antisense, transcript variant 1 (from RefSeq NM_029602.1) ENSMUST00000040177.1 ENSMUST00000040177.2 ENSMUST00000040177.3 ENSMUST00000040177.4 ENSMUST00000040177.5 ENSMUST00000040177.6 ENSMUST00000040177.7 NM_029602 Q8R0E5 Q9DA28 Tctex4 ZRAS1_MOUSE Znrd1-as Znrd1as uc008clq.1 uc008clq.2 uc008clq.3 uc008clq.4 May be involved in male sterility. Specifically expressed in testis. Sequence=AAH27007.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB24473.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB24473.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc008clq.1 uc008clq.2 uc008clq.3 uc008clq.4 
ENSMUST00000040179.14 Ttll5 ENSMUST00000040179.14 tubulin tyrosine ligase-like family, member 5, transcript variant 7 (from RefSeq NM_001364628.1) A4Q9E7 ENSMUST00000040179.1 ENSMUST00000040179.10 ENSMUST00000040179.11 ENSMUST00000040179.12 ENSMUST00000040179.13 ENSMUST00000040179.2 ENSMUST00000040179.3 ENSMUST00000040179.4 ENSMUST00000040179.5 ENSMUST00000040179.6 ENSMUST00000040179.7 ENSMUST00000040179.8 ENSMUST00000040179.9 Kiaa0998 NM_001364628 Q3V468 Q8C1F0 Q8CFV5 Q8CHB8 Q9CVS6 TTLL5_MOUSE Ttll5 uc007ohj.1 uc007ohj.2 uc007ohj.3 uc007ohj.4 Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:17499049). Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step (PubMed:17499049). Preferentially modifies the alpha-tubulin tail over a beta-tail (PubMed:17499049). Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules (By similarity). Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (By similarity). Reaction=ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L- glutamyl-L-glutamyl-[protein] + H(+) + phosphate; Xref=Rhea:RHEA:60144, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15517, ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143622, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60145; Evidence=; Reaction=(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60148, Rhea:RHEA-COMP:15519, Rhea:RHEA-COMP:15675, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143623, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60149; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with the transcriptional coactivators NCOA1/SRC-1 and NCOA2/TIF2. Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Nucleus Cytoplasm te=In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid (By similarity). Localized to the base of the connecting cilium between the basal body and the adjacent daughter centriole of the cilium. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CHB8-1; Sequence=Displayed; Name=2; IsoId=Q8CHB8-2; Sequence=VSP_041931; Highly expressed in brain, kidney, liver, spleen and testis (PubMed:17499049). Expressed in heart, lung, muscle and trachea (PubMed:17499049). The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding. Arg-186 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate- chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the tubulin--tyrosine ligase family. Sequence=AAH35276.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC41462.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE43213.1; Type=Frameshift; Evidence=; nucleotide binding molecular_function ATP binding nucleus cytoplasm centrosome cytosol cytoskeleton microtubule plasma membrane cilium cellular protein modification process spermatogenesis sperm axoneme assembly fertilization ligase activity protein polyglutamylation flagellated sperm motility cell projection retina development in camera-type eye uc007ohj.1 uc007ohj.2 uc007ohj.3 uc007ohj.4 
ENSMUST00000040182.13 Ccdc88a ENSMUST00000040182.13 coiled coil domain containing 88A, transcript variant 3 (from RefSeq NM_176841.5) ENSMUST00000040182.1 ENSMUST00000040182.10 ENSMUST00000040182.11 ENSMUST00000040182.12 ENSMUST00000040182.2 ENSMUST00000040182.3 ENSMUST00000040182.4 ENSMUST00000040182.5 ENSMUST00000040182.6 ENSMUST00000040182.7 ENSMUST00000040182.8 ENSMUST00000040182.9 GRDN_MOUSE Grdn Kiaa1212 NM_176841 Q5M6X2 Q5M6X4 Q5M6X5 Q5SNZ0 Q5SNZ1 Q8C486 Q8CFU7 uc007igw.1 uc007igw.2 uc007igw.3 uc007igw.4 Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (By similarity). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (By similarity). Essential for cell migration (By similarity). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (By similarity). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (By similarity). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (PubMed:15753085). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (By similarity). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (PubMed:19778506). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton (By similarity). Required for formation of actin stress fibers and lamellipodia (By similarity). May be involved in membrane sorting in the early endosome (By similarity). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (By similarity). Homodimer (By similarity). Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunits GNAI1, GNAI2 and GNAI3 (By similarity). Also interacts (via GNA motif) with guanine nucleotide-binding protein G(s) alpha subunit GNAS (By similarity). Interaction with G(i) alpha subunits occurs before interaction with GNAS and is regulated by phosphorylation; phosphorylation at Ser-1677 enhances binding to G(i) alpha subunits while phosphorylation at Ser- 1692 abolishes G(i) alpha subunit binding, promoting binding to GNAS (By similarity). Interacts (via C-terminal SH2-like region) with growth factor receptors EGFR, INSR and KDR/VEGFR2 (via their autophosphorylated cytoplasmic tails) (By similarity). Forms a complex with EGFR and GNAI3 which leads to enhanced EGFR signaling and triggering of cell migration; ligand stimulation is required for recruitment of GNAI3 to the complex (By similarity). Interacts (tyrosine-phosphorylated form) with phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1/p85a (via SH2 domains); the interaction enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (By similarity). Interacts with serine/threonine-protein kinase PRKCQ; the interaction leads to phosphorylation of CCDC88A and inhibition of its guanine nucleotide exchange factor activity (By similarity). Interacts (via C-terminus) with DISC1; the interaction is direct (PubMed:19778506). Interacts with AKT proteins; the interaction is inhibited in the presence of DISC1 (PubMed:19778506). Interacts with AKT1/PKB (via C-terminus) (PubMed:15753085). The non-phosphorylated form interacts with phosphatidylinositol 4-phosphate [Pi(4)P] and weakly with phosphatidylinositol 3-phosphate [Pi(3)P] (By similarity). Interacts with microtubules (PubMed:15882442). Interacts with actin (By similarity). Cell membrane ; Peripheral membrane protein Cytoplasm, cytosol Cytoplasmic vesicle Cell projection, lamellipodium Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localizes to the cytosol in unstimulated cells while EGF stimulation promotes membrane localization and guanine nucleotide exchange factor activity (By similarity). Localizes to the cell membrane through interaction with phosphoinositides (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5SNZ0-1; Sequence=Displayed; Name=2 ; IsoId=Q5SNZ0-2; Sequence=VSP_052411; Name=3; IsoId=Q5SNZ0-3; Sequence=VSP_052410, VSP_052411; Expressed in the dentate gyrus, pyramidal cell layer of hippocampal regions CA1 and CA3 at postnatal 15. Expressed highly in neurons. Weakly in neuron progenitors (at protein level). Expressed in the dentate granule cell layer of the hippocampus. Expressed highly in the adult testis, moderately in the brain and at a low level in the spleen, lungs and fat. Temporally and spatially restricted during embryogenesis. At 10.5 dpc, expressed in the branchial arches, nasal processes, limbs, somites and dorsal root ganglia. At 11.5 dpc, expression persists at these sites in addition to the eye and fore-, mid- and hindbrain. By 12.5 dpc, expressed in the interdigital mesenchyme of the limbs. At 13.5 dpc, expression in the limbs flanks the digits and also appears in a subset of tendons in the hind- and forelimbs. The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins). In the presence of tyrosine-autophosphorylated growth factor receptors, the C-terminus folds into an SH2-like region which promotes the stable recruitment of CCDC88A to the growth factor receptors. The SH2-like region is phosphorylated by the growth factor receptors prior to completion of folding. Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner (By similarity). Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration (By similarity). Phosphorylated on tyrosine residues which promotes binding to phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1/p85a and enhances PI3K activity (By similarity). Tyrosine-phosphorylated by both receptor and non-receptor tyrosine kinases in vitro (By similarity). Tyrosine phosphorylation is required for AKT1-dependent phosphorylation of Ser-1417 (By similarity). Phosphorylation at Ser-1692 by PRKCQ disrupts interaction with GNAI3 and inhibits guanine nucleotide exchange factor activity (By similarity). CCDC88A knockout mice display mesial-temporal lobe epilepsy and early demise, and structural brain developmental defects affecting the corpus callosum and cerebrum. Belongs to the CCDC88 family. Sequence=AAH37020.1; Type=Erroneous initiation; Evidence=; Sequence=CAI24877.1; Type=Erroneous gene model prediction; Evidence=; regulation of protein phosphorylation actin binding protein binding cytoplasm endoplasmic reticulum Golgi apparatus centrosome centriole cytosol cytoskeleton plasma membrane DNA replication regulation of DNA replication nervous system development microtubule binding regulation of neuron projection development membrane cell migration lamellipodium cell projection organization lamellipodium assembly Golgi to ER transport vesicle cytoskeleton-dependent intracellular transport cytoplasmic microtubule organization cell leading edge cytoplasmic vesicle G-protein gamma-subunit binding TOR signaling activation of protein kinase B activity regulation of actin cytoskeleton organization phosphatidylinositol binding ciliary basal body regulation of cell proliferation protein homodimerization activity cell projection protein kinase B binding positive regulation of cilium assembly dynein light intermediate chain binding membrane organization positive regulation of protein localization to cilium uc007igw.1 uc007igw.2 uc007igw.3 uc007igw.4 
ENSMUST00000040184.4 Trpc5 ENSMUST00000040184.4 transient receptor potential cation channel, subfamily C, member 5 (from RefSeq NM_009428.3) ENSMUST00000040184.1 ENSMUST00000040184.2 ENSMUST00000040184.3 NM_009428 Q61059 Q9QWT1 Q9QX29 Q9R0D4 TRPC5_MOUSE Trp5 Trrp5 uc009umv.1 uc009umv.2 uc009umv.3 uc009umv.4 Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion (By similarity). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (PubMed:32110987). Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane. Homotetramer and heterotetramer with TRPC1 and/or TRPC4 (By similarity). Interacts (via C-terminus) with CABP1 (PubMed:15895247). Interacts with SLC9A3R1/NHERF (PubMed:10980202). Interacts with MX1 and RNF24 (By similarity). Interacts with SESTD1 (via the spectrin 1 repeat) (By similarity). Interacts with TRPC4AP (PubMed:20458742). Interacts with PLSCR1 (PubMed:32110987). Cell membrane ; Multi-pass membrane protein Expressed almost exclusively in brain, in mitral cells of the olfactory bulb, in lateral cerebellar nuclei and in pyramidal neurons of the hippocampus. Very low levels detected in liver kidney, testis, and uterus. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily. actin binding ion channel activity calcium channel activity protein binding cytoplasm plasma membrane integral component of plasma membrane ion transport calcium ion transport manganese ion transport positive regulation of cytosolic calcium ion concentration positive regulation of cell proliferation positive regulation of peptidyl-threonine phosphorylation store-operated calcium channel activity membrane integral component of membrane neuron differentiation clathrin binding dendrite growth cone cation channel complex calcium channel complex actinin binding neuronal cell body membrane raft positive regulation of neuron differentiation positive regulation of axon extension negative regulation of dendrite morphogenesis ATPase binding regulation of cytosolic calcium ion concentration transmembrane transport calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding regulation of membrane hyperpolarization uc009umv.1 uc009umv.2 uc009umv.3 uc009umv.4 
ENSMUST00000040202.15 Atxn2l ENSMUST00000040202.15 ataxin 2-like, transcript variant 1 (from RefSeq NM_183020.3) A2lp ATX2L_MOUSE ENSMUST00000040202.1 ENSMUST00000040202.10 ENSMUST00000040202.11 ENSMUST00000040202.12 ENSMUST00000040202.13 ENSMUST00000040202.14 ENSMUST00000040202.2 ENSMUST00000040202.3 ENSMUST00000040202.4 ENSMUST00000040202.5 ENSMUST00000040202.6 ENSMUST00000040202.7 ENSMUST00000040202.8 ENSMUST00000040202.9 NM_183020 Q7TQH0 Q80XN9 Q8K059 uc009jrs.1 uc009jrs.2 uc009jrs.3 Involved in the regulation of stress granule and P-body formation. Interacts with MPL/TPOR and EPOR and dissociates after ligand stimulation. Interacts with DDX6, G3BP, and ATXN2. Interacts with PRMT1 (By similarity). Interacts with CIC and ATXN1 (PubMed:17322884). Membrane ; Peripheral membrane protein Cytoplasm Nucleus speckle Cytoplasmic granule Note=Predominantly cytoplasmic but is also detected in nuclear speckles. Component of cytoplasmic stress granules. Inhibition of methylation alters nuclear localization. Methylation does not seem to be required for localization to stress granules under stress conditions. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7TQH0-1; Sequence=Displayed; Name=2; IsoId=Q7TQH0-2; Sequence=VSP_011595, VSP_011596; Name=3; IsoId=Q7TQH0-3; Sequence=VSP_011595; Expressed in cerebellum. Thrombopoietin triggers the phosphorylation on tyrosine residues in a way that is dependent on MPL C-terminal domain. Asymmetrically dimethylated. Probably methylated by PRMT1. Belongs to the ataxin-2 family. nucleus cytoplasm cytosol cytoplasmic stress granule regulation of cytoplasmic mRNA processing body assembly membrane nuclear speck stress granule assembly uc009jrs.1 uc009jrs.2 uc009jrs.3 
ENSMUST00000040213.13 Tyw1 ENSMUST00000040213.13 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae), transcript variant 12 (from RefSeq NR_188930.1) ENSMUST00000040213.1 ENSMUST00000040213.10 ENSMUST00000040213.11 ENSMUST00000040213.12 ENSMUST00000040213.2 ENSMUST00000040213.3 ENSMUST00000040213.4 ENSMUST00000040213.5 ENSMUST00000040213.6 ENSMUST00000040213.7 ENSMUST00000040213.8 ENSMUST00000040213.9 NR_188930 Q3TRC5 Q8BJM7 Q8BLG4 Q8R0C7 Rsafd1 TYW1_MOUSE uc008zul.1 uc008zul.2 uc008zul.3 uc008zul.4 Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity). Reaction=N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl- L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine; Xref=Rhea:RHEA:36347, Rhea:RHEA- COMP:10164, Rhea:RHEA-COMP:10165, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:16526, ChEBI:CHEBI:17319, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:64315, ChEBI:CHEBI:73542; EC=4.1.3.44; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. ; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BJM7-1; Sequence=Displayed; Name=2; IsoId=Q8BJM7-3; Sequence=VSP_024068, VSP_024070; Belongs to the TYW1 family. Sequence=BAC32293.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; nucleotide binding catalytic activity tRNA processing biological_process FMN binding lyase activity metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding oxidation-reduction process uc008zul.1 uc008zul.2 uc008zul.3 uc008zul.4 
ENSMUST00000040217.6 Tbc1d21 ENSMUST00000040217.6 TBC1 domain family, member 21, transcript variant 3 (from RefSeq NR_151687.1) B7ZNH3 ENSMUST00000040217.1 ENSMUST00000040217.2 ENSMUST00000040217.3 ENSMUST00000040217.4 ENSMUST00000040217.5 MgcRabGAP NR_151687 Q9D9D3 TBC21_MOUSE Tbc1d21 uc009pww.1 uc009pww.2 uc009pww.3 Acts as a GTPase-activating protein for Rab family protein (s) (PubMed:30360518). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function (PubMed:32976492). Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail (PubMed:32976492). Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3 (PubMed:33536340). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978). Interacts with ACTB (PubMed:21128978). Interacts with ARMC12 (PubMed:33536340). Interacts with TOMM20 and DNAH7 (PubMed:32976492). Interacts with RAP1A (PubMed:30360518). Interacts with RAB10 (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasm, cytoskeleton Note=Located at the edge of the acrosomal region, neck and annulus during spermiogenesis. Colocalizes with RAB3A at the acrosome-acroplaxome and neck regions of spermatids. Colocalizes with ACTB at the neck region in elongated spermatids. Expressed in testis, specifically in elongating and elongated spermatids (at protein level) (PubMed:21128978, PubMed:30360518, PubMed:33536340). Expressed in the sperm midpiece (at protein level) (PubMed:32976492, PubMed:33536340). Detected from postnatal day 35 onward. Male mice are sterile, characterized by defects in sperm tail structure and diminished sperm motility (PubMed:32976492, PubMed:33536340). The mitochondria of the sperm-tail has an abnormal irregular arrangement, abnormal diameter, and structural defects and the axoneme structure of sperm tails is severely disturbed (PubMed:32976492). Sperm mitochondria cannot form a proper mitochondrial sheath at the subsequent mitochondrial compaction step, although they can coil around the flagellum (PubMed:33536340). acrosomal vesicle actin binding GTPase activator activity cytoplasm cytoskeleton intracellular protein transport spermatogenesis Rab GTPase binding cell differentiation cytoplasmic vesicle activation of GTPase activity uc009pww.1 uc009pww.2 uc009pww.3 
ENSMUST00000040218.13 Fbxo8 ENSMUST00000040218.13 F-box protein 8, transcript variant 1 (from RefSeq NM_015791.4) ENSMUST00000040218.1 ENSMUST00000040218.10 ENSMUST00000040218.11 ENSMUST00000040218.12 ENSMUST00000040218.2 ENSMUST00000040218.3 ENSMUST00000040218.4 ENSMUST00000040218.5 ENSMUST00000040218.6 ENSMUST00000040218.7 ENSMUST00000040218.8 ENSMUST00000040218.9 FBX8_MOUSE Fbx8 NM_015791 Q8JZY7 Q9QZN3 uc009lsr.1 uc009lsr.2 uc009lsr.3 May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential). High expression in brain, heart, kidney, liver, lung, skeletal muscle, testis, and day-7 embryos. ubiquitin ligase complex guanyl-nucleotide exchange factor activity ARF guanyl-nucleotide exchange factor activity ubiquitin-dependent protein catabolic process regulation of ARF protein signal transduction uc009lsr.1 uc009lsr.2 uc009lsr.3 
ENSMUST00000040227.3 Cldnd2 ENSMUST00000040227.3 claudin domain containing 2, transcript variant 1 (from RefSeq NM_028849.2) CLDN2_MOUSE ENSMUST00000040227.1 ENSMUST00000040227.2 NM_028849 Q9D9H2 uc009gms.1 uc009gms.2 uc009gms.3 Membrane ; Multi-pass membrane protein Belongs to the PMP-22/EMP/MP20 family. molecular_function plasma membrane biological_process membrane integral component of membrane uc009gms.1 uc009gms.2 uc009gms.3 
ENSMUST00000040234.9 Tsen2 ENSMUST00000040234.9 tRNA splicing endonuclease subunit 2, transcript variant 1 (from RefSeq NM_199033.3) ENSMUST00000040234.1 ENSMUST00000040234.2 ENSMUST00000040234.3 ENSMUST00000040234.4 ENSMUST00000040234.5 ENSMUST00000040234.6 ENSMUST00000040234.7 ENSMUST00000040234.8 NM_199033 Q3UYG6 Q6P7W5 SEN2_MOUSE Sen2 uc009diu.1 uc009diu.2 uc009diu.3 Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity). Reaction=pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'- half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.; EC=4.6.1.16; tRNA splicing endonuclease is a heterotetramer composed of TSEN2, TSEN15, TSEN34/LENG5 and TSEN54. tRNA splicing endonuclease complex also contains proteins of the pre-mRNA 3'-end processing machinery such as CLP1, CPSF1, CPSF4 and CSTF2 (By similarity). Nucleus Nucleus, nucleolus Note=May be transiently localized in the nucleolus. Belongs to the tRNA-intron endonuclease family. tRNA-intron endonuclease activity tRNA-intron endonuclease complex tRNA-type intron splice site recognition and cleavage nucleic acid binding nuclease activity nucleus nucleoplasm nucleolus centrosome cytosol tRNA splicing, via endonucleolytic cleavage and ligation mRNA processing tRNA processing lyase activity nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc009diu.1 uc009diu.2 uc009diu.3 
ENSMUST00000040241.15 Ddx19b ENSMUST00000040241.15 DEAD box helicase 19b, transcript variant 2 (from RefSeq NM_172284.5) Ddx19b ENSMUST00000040241.1 ENSMUST00000040241.10 ENSMUST00000040241.11 ENSMUST00000040241.12 ENSMUST00000040241.13 ENSMUST00000040241.14 ENSMUST00000040241.2 ENSMUST00000040241.3 ENSMUST00000040241.4 ENSMUST00000040241.5 ENSMUST00000040241.6 ENSMUST00000040241.7 ENSMUST00000040241.8 ENSMUST00000040241.9 NM_172284 Q8R3C7 Q8R3C7_MOUSE uc009nlm.1 uc009nlm.2 uc009nlm.3 uc009nlm.4 nucleic acid binding RNA binding ATP binding nucleus nuclear envelope cytoplasmic stress granule poly(A)+ mRNA export from nucleus uc009nlm.1 uc009nlm.2 uc009nlm.3 uc009nlm.4 
ENSMUST00000040248.9 Spidr ENSMUST00000040248.9 scaffolding protein involved in DNA repair, transcript variant 1 (from RefSeq NM_146068.4) ENSMUST00000040248.1 ENSMUST00000040248.2 ENSMUST00000040248.3 ENSMUST00000040248.4 ENSMUST00000040248.5 ENSMUST00000040248.6 ENSMUST00000040248.7 ENSMUST00000040248.8 Kiaa0146 NM_146068 Q3TCD0 Q5U457 Q6A0B6 Q6IS60 Q811E1 Q8BGX7 Q8BWD6 Q8R305 SPIDR_MOUSE uc007yhz.1 uc007yhz.2 uc007yhz.3 uc007yhz.4 Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity (By similarity). Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts (via C-terminal region) with BLM; the interaction is direct. Interacts with RAD51; the interaction is direct. Interacts (via the C-terminal region) with FIGNL1 (via N-terminal one-half region); the interaction is direct (By similarity). Nucleus Note=Together with BLM, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BGX7-1; Sequence=Displayed; Name=2; IsoId=Q8BGX7-2; Sequence=VSP_020769; Name=3; IsoId=Q8BGX7-3; Sequence=VSP_020767, VSP_020768; Sequence=AAH26877.1; Type=Frameshift; Evidence=; Sequence=BAC35167.1; Type=Frameshift; Evidence=; Sequence=BAD32180.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nuclear chromosome double-strand break repair via homologous recombination molecular_function nucleus nucleoplasm DNA repair DNA recombination cellular response to DNA damage stimulus regulation of double-strand break repair via homologous recombination positive regulation of protein complex assembly regulation of establishment of protein localization to chromosome cellular response to ionizing radiation cellular response to hydroxyurea cellular response to camptothecin positive regulation of double-strand break repair uc007yhz.1 uc007yhz.2 uc007yhz.3 uc007yhz.4 
ENSMUST00000040250.15 Kmo ENSMUST00000040250.15 kynurenine 3-monooxygenase (from RefSeq NM_133809.1) ENSMUST00000040250.1 ENSMUST00000040250.10 ENSMUST00000040250.11 ENSMUST00000040250.12 ENSMUST00000040250.13 ENSMUST00000040250.14 ENSMUST00000040250.2 ENSMUST00000040250.3 ENSMUST00000040250.4 ENSMUST00000040250.5 ENSMUST00000040250.6 ENSMUST00000040250.7 ENSMUST00000040250.8 ENSMUST00000040250.9 KMO_MOUSE Kmo NM_133809 Q91WN4 uc007dtp.1 uc007dtp.2 uc007dtp.3 Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Reaction=H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+); Xref=Rhea:RHEA:20545, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:57959, ChEBI:CHEBI:58125, ChEBI:CHEBI:58349; EC=1.14.13.9; Evidence= Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. Mitochondrion outer membrane ulti-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q91WN4-1; Sequence=Displayed; Name=2 ; IsoId=Q91WN4-2; Sequence=VSP_051974; Expressed by organs containing secondary lymphoid tissue, such as the lung, spleen, mesenteric lymph node, thymus and peripheral lymph nodes. Transmembrane domains are required for enzymatic activity. Mutants show normal fecundity, fertility and longevity up tp 2 year. They have reduced serum 3-hydroxy-L-kynurenine concentrations. They are protected against extrapancreatic tissue injury to the lung, kidney and liver produced by acute pancreatitis- induced multiple organ dysfunction syndrome. Belongs to the aromatic-ring hydroxylase family. KMO subfamily. monooxygenase activity kynurenine 3-monooxygenase activity extracellular space mitochondrion mitochondrial outer membrane mitochondrial inner membrane tryptophan catabolic process aging NAD biosynthetic process response to salt stress positive regulation of glutamate secretion membrane integral component of membrane NAD(P)H oxidase activity oxidoreductase activity pyridine nucleotide biosynthetic process NAD metabolic process quinolinate biosynthetic process mitochondrial membrane response to lipopolysaccharide kynurenic acid biosynthetic process 'de novo' NAD biosynthetic process from tryptophan anthranilate metabolic process flavin adenine dinucleotide binding oxidation-reduction process kynurenine metabolic process cellular response to lipopolysaccharide cellular response to interleukin-1 FAD binding L-kynurenine metabolic process positive regulation of neuron death positive regulation of glutamate secretion, neurotransmission uc007dtp.1 uc007dtp.2 uc007dtp.3 
ENSMUST00000040254.16 Edc4 ENSMUST00000040254.16 enhancer of mRNA decapping 4, transcript variant 4 (from RefSeq NM_001404071.1) ENSMUST00000040254.1 ENSMUST00000040254.10 ENSMUST00000040254.11 ENSMUST00000040254.12 ENSMUST00000040254.13 ENSMUST00000040254.14 ENSMUST00000040254.15 ENSMUST00000040254.2 ENSMUST00000040254.3 ENSMUST00000040254.4 ENSMUST00000040254.5 ENSMUST00000040254.6 ENSMUST00000040254.7 ENSMUST00000040254.8 ENSMUST00000040254.9 Edc4 G5E896 G5E896_MOUSE NM_001404071 uc009nel.1 uc009nel.2 uc009nel.3 Cytoplasm, P-body Belongs to the WD repeat EDC4 family. P-body nucleus nucleoplasm cytoplasmic ribonucleoprotein granule uc009nel.1 uc009nel.2 uc009nel.3 
ENSMUST00000040259.8 Atp6v0a4 ENSMUST00000040259.8 ATPase, H+ transporting, lysosomal V0 subunit A4 (from RefSeq NM_080467.3) Atp6n1b ENSMUST00000040259.1 ENSMUST00000040259.2 ENSMUST00000040259.3 ENSMUST00000040259.4 ENSMUST00000040259.5 ENSMUST00000040259.6 ENSMUST00000040259.7 NM_080467 Q8CJ79 Q920B5 Q920R6 VPP4_MOUSE uc009bjp.1 uc009bjp.2 uc009bjp.3 Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Involved in normal vectorial acid transport into the urine by the kidney (By similarity). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with the V1 complex V-ATPase subunit A ATP6V1A (PubMed:11498539). Interacts with the V0 complex V-ATPase subunit c ATP6V0C (PubMed:11498539). Apical cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Note=Localizes to the apical surface of alpha-intercalated cells in the cortical collecting ducts of the distal nephron (PubMed:11498539, PubMed:11495928). Localizes to the basolateral surface of beta-intercalated cells in the cortical collecting ducts of the distal nephron (PubMed:11498539, PubMed:11495928). Specifically expressed in kidney, but not in the heart, brain, spleen, lung, liver, muscle, or testis. Distribution within the kidney appears more widespread than that seen in man. High intensity staining at the surface of intercalated cells, with additional expression in the proximal tubule. Belongs to the V-ATPase 116 kDa subunit family. vacuolar proton-transporting V-type ATPase, V0 domain ossification endosome plasma membrane brush border ion transport regulation of pH vacuolar acidification excretion sensory perception of sound hydrogen-exporting ATPase activity, phosphorylative mechanism hydrogen ion transmembrane transporter activity membrane integral component of membrane apical plasma membrane vacuolar proton-transporting V-type ATPase complex brush border membrane proton-transporting V-type ATPase, V0 domain apical part of cell proton-transporting ATPase activity, rotational mechanism ATPase binding hydrogen ion transmembrane transport uc009bjp.1 uc009bjp.2 uc009bjp.3 
ENSMUST00000040260.11 Frrs1 ENSMUST00000040260.11 ferric-chelate reductase 1, transcript variant 1 (from RefSeq NM_001113478.2) A0A0G2JFP4 A0A0G2JFP4_MOUSE ENSMUST00000040260.1 ENSMUST00000040260.10 ENSMUST00000040260.2 ENSMUST00000040260.3 ENSMUST00000040260.4 ENSMUST00000040260.5 ENSMUST00000040260.6 ENSMUST00000040260.7 ENSMUST00000040260.8 ENSMUST00000040260.9 Frrs1 NM_001113478 uc008rcv.1 uc008rcv.2 uc008rcv.3 uc008rcv.4 Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the FRRS1 family. membrane integral component of membrane oxidation-reduction process uc008rcv.1 uc008rcv.2 uc008rcv.3 uc008rcv.4 
ENSMUST00000040261.7 Macrod1 ENSMUST00000040261.7 mono-ADP ribosylhydrolase 1, transcript variant 1 (from RefSeq NM_134147.5) ENSMUST00000040261.1 ENSMUST00000040261.2 ENSMUST00000040261.3 ENSMUST00000040261.4 ENSMUST00000040261.5 ENSMUST00000040261.6 Lrp16 MACD1_MOUSE Macrod1 NM_134147 Q922B1 uc008gkg.1 uc008gkg.2 uc008gkg.3 uc008gkg.4 uc008gkg.5 Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed- forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down- regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. Reaction=3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+); Xref=Rhea:RHEA:59244, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:142723; EC=3.1.1.106; Evidence=; Reaction=2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+); Xref=Rhea:RHEA:57060, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:83767; EC=3.1.1.106; Evidence=; Reaction=4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose + H(+) + L-aspartyl-[protein]; Xref=Rhea:RHEA:54428, Rhea:RHEA- COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29961, ChEBI:CHEBI:57967, ChEBI:CHEBI:138102; Evidence=; Reaction=5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = ADP-D-ribose + H(+) + L-glutamyl-[protein]; Xref=Rhea:RHEA:58248, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:57967, ChEBI:CHEBI:142540; Evidence=; Reaction=alpha-NAD(+) + H2O = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:68792, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57967, ChEBI:CHEBI:77017; Evidence=; Subject to competitive inhibition by the product ADP-ribose. Interacts with ESR1; Interacts in a manner that is estrogen independent but is enhanced by estrogen. Interacts (via macro domain) with AR. Nucleus Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. Sequence=AAH08653.1; Type=Erroneous initiation; Evidence=; Sequence=BAC35234.1; Type=Erroneous initiation; Evidence=; nucleus nucleoplasm mitochondrion cellular response to DNA damage stimulus hydrolase activity hydrolase activity, acting on glycosyl bonds deacetylase activity purine nucleoside metabolic process protein de-ADP-ribosylation uc008gkg.1 uc008gkg.2 uc008gkg.3 uc008gkg.4 uc008gkg.5 
ENSMUST00000040270.6 Actr1a ENSMUST00000040270.6 ARP1 actin-related protein 1A, centractin alpha, transcript variant 1 (from RefSeq NM_016860.2) ACTZ_MOUSE Ctrn1 ENSMUST00000040270.1 ENSMUST00000040270.2 ENSMUST00000040270.3 ENSMUST00000040270.4 ENSMUST00000040270.5 NM_016860 P42024 P61164 Q3TJF9 uc008htm.1 uc008htm.2 uc008htm.3 Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The filament contains 8 copies of ACTR1A and 1 ACTB. Interacts with dynein and adapters such as BICD2 (By similarity). Interacts with BCCIP (isoform 2/alpha) (By similarity). Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cell cortex Belongs to the actin family. ARP1 subfamily. establishment of mitotic spindle orientation nucleotide binding manchette ATP binding cytoplasm centrosome centriole microtubule organizing center cytoskeleton dynactin complex cell cortex spermatogenesis microtubule cytoskeleton COPI-coated vesicle nuclear migration along microtubule myelin sheath cell cortex region uc008htm.1 uc008htm.2 uc008htm.3 
ENSMUST00000040271.12 Cep85 ENSMUST00000040271.12 centrosomal protein 85 (from RefSeq NM_144527.3) CEP85_MOUSE Ccdc21 ENSMUST00000040271.1 ENSMUST00000040271.10 ENSMUST00000040271.11 ENSMUST00000040271.2 ENSMUST00000040271.3 ENSMUST00000040271.4 ENSMUST00000040271.5 ENSMUST00000040271.6 ENSMUST00000040271.7 ENSMUST00000040271.8 ENSMUST00000040271.9 NM_144527 Q8BMK0 Q8BUF1 Q8K0E6 uc008ved.1 uc008ved.2 uc008ved.3 uc008ved.4 Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility. Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity. Homodimer. Interacts with STIL (via N-terminus); this interaction is essential for robust PLK4 activation and efficient centriole assembly and for PLK4-dependent cell migration. Interacts with PLK4; required for CEP85 to be able to drive centriole duplication and cell migration. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Nucleus, nucleolus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cell cortex Note=Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus and accumulates at spindle poles. Associated with the pericentriolar material. Localizes to centrosomes at a low level in G1 phase and a slightly increased level in S phase, with gradually elevated levels during G2 phase. The levels at centrosomes further increase at G2/M, reaching a peak at spindle poles at early mitotic stages and remain high until the end of anaphase. Localizes at the leading edge. Belongs to the CEP85 family. pericentriolar material spindle pole molecular_function nucleus nucleolus cytoplasm mitochondrion Golgi apparatus centrosome microtubule organizing center cytosol cytoskeleton negative regulation of protein kinase activity chromosome segregation regulation of mitotic centrosome separation uc008ved.1 uc008ved.2 uc008ved.3 uc008ved.4 
ENSMUST00000040275.9 Sobp ENSMUST00000040275.9 sine oculis binding protein (from RefSeq NM_175407.3) ENSMUST00000040275.1 ENSMUST00000040275.2 ENSMUST00000040275.3 ENSMUST00000040275.4 ENSMUST00000040275.5 ENSMUST00000040275.6 ENSMUST00000040275.7 ENSMUST00000040275.8 Jxc1 NM_175407 Q0P5V2 SOBP_MOUSE Sobp uc007ezf.1 uc007ezf.2 Implicated in development of the cochlea. Interacts (via SIM domains) with SUMO1 and SUMO2. Present at 14.5 dpc throughout the developing brain, with high expression in the cortical plate. During postnatal development, detected in all neurons, with an intense expression in the limbic system, with highest levels throughout layer V neurons in the cortex, the hippocampus, the pyriform cortex, the dorsomedial nucleus of the thalamus, the amygdala, and the hypothalamus. Cortical expression is strong throughout development, with no clear dorsoventral or rostrocaudal gradient, highest levels at P10 in layers II/III and V and in the subplate. Relatively strong expression in the mitral cells layer and anterior olfactory bulb, as well as in the Purkinje cell layer in the cerebellum. Expression in the limbic system postnatally corresponds to the time window of active synaptogenesis. Belongs to the SOBP family. nucleus sensory perception of sound locomotory behavior SUMO polymer binding inner ear morphogenesis metal ion binding cognition cochlea development uc007ezf.1 uc007ezf.2 
ENSMUST00000040280.14 Slc25a23 ENSMUST00000040280.14 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23, transcript variant 1 (from RefSeq NM_025877.4) ENSMUST00000040280.1 ENSMUST00000040280.10 ENSMUST00000040280.11 ENSMUST00000040280.12 ENSMUST00000040280.13 ENSMUST00000040280.2 ENSMUST00000040280.3 ENSMUST00000040280.4 ENSMUST00000040280.5 ENSMUST00000040280.6 ENSMUST00000040280.7 ENSMUST00000040280.8 ENSMUST00000040280.9 NM_025877 Q6GQS1 SCMC3_MOUSE Scamc3 Slc25a23 uc008ddu.1 uc008ddu.2 uc008ddu.3 Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways. Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP. In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides. Reaction=ATP(out) + Mg(2+)(out) + phosphate(in) = ATP(in) + Mg(2+)(in) + phosphate(out); Xref=Rhea:RHEA:65840, ChEBI:CHEBI:18420, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474; Evidence=; Reaction=ADP(out) + H(+)(out) + phosphate(in) = ADP(in) + H(+)(in) + phosphate(out); Xref=Rhea:RHEA:65844, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Reaction=AMP(out) + phosphate(in) = AMP(in) + phosphate(out); Xref=Rhea:RHEA:70259, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; Evidence=; Reaction=ATP(out) + 2 H(+)(out) + phosphate(in) = ATP(in) + 2 H(+)(in) + phosphate(out); Xref=Rhea:RHEA:72035, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474; Evidence=; Reaction=ADP(out) + dADP(in) = ADP(in) + dADP(out); Xref=Rhea:RHEA:72855, ChEBI:CHEBI:57667, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(out) + ATP(in) + H(+)(out) + Mg(2+)(in) = ADP(in) + ATP(out) + H(+)(in) + Mg(2+)(out); Xref=Rhea:RHEA:73659, ChEBI:CHEBI:15378, ChEBI:CHEBI:18420, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(out) + diphosphate(in) = ADP(in) + diphosphate(out); Xref=Rhea:RHEA:73671, ChEBI:CHEBI:33019, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(out) + dAMP(in) + H(+)(out) = ADP(in) + dAMP(out) + H(+)(in); Xref=Rhea:RHEA:73675, ChEBI:CHEBI:15378, ChEBI:CHEBI:58245, ChEBI:CHEBI:456216; Evidence=; Reaction=3'-AMP(in) + ADP(out) + H(+)(out) = 3'-AMP(out) + ADP(in) + H(+)(in); Xref=Rhea:RHEA:73679, ChEBI:CHEBI:15378, ChEBI:CHEBI:60880, ChEBI:CHEBI:456216; Evidence=; Reaction=dAMP(out) + phosphate(in) = dAMP(in) + phosphate(out); Xref=Rhea:RHEA:73687, ChEBI:CHEBI:43474, ChEBI:CHEBI:58245; Evidence=; Reaction=3'-AMP(out) + phosphate(in) = 3'-AMP(in) + phosphate(out); Xref=Rhea:RHEA:73691, ChEBI:CHEBI:43474, ChEBI:CHEBI:60880; Evidence=; Reaction=dADP(out) + H(+)(out) + phosphate(in) = dADP(in) + H(+)(in) + phosphate(out); Xref=Rhea:RHEA:73695, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57667; Evidence=; Activated by an increase in cytosolic calcium levels that induce a conformational change of the N-terminal regulatory domain, uncapping the channel and allowing transport. Interacts with MCU. Interacts with MICU1. Mitochondrion inner membrane ; Multi-pass membrane protein The regulatory N-terminal domain/NTD, binds calcium in the mitochondrial intermembrane space and regulates the antiporter activity of the transmembrane domain/TMD. In absence of calcium, the apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, inhibiting the transporter activity. Binding of calcium leads to a major conformational change and abolishes the interaction with the transmembrane domain and the inhibition of the transporter activity. The C-terminal mitochondrial carrier domain/transmembrane domain/TMD bears the transmembrane transporter activity. Linker region/H9 could directly block the transport of substrates across the transporter. Belongs to the mitochondrial carrier (TC 2.A.29) family. regulation of oxidative phosphorylation ATP transmembrane transporter activity calcium ion binding mitochondrion mitochondrial inner membrane mitochondrial calcium ion transport ATP transport membrane integral component of membrane transmembrane transporter activity mitochondrial calcium uptake regulation of cellular respiration metal ion binding regulation of sequestering of calcium ion adenine nucleotide transport positive regulation of mitochondrial calcium ion concentration transmembrane transport cellular response to calcium ion urea homeostasis regulation of cellular hyperosmotic salinity response uc008ddu.1 uc008ddu.2 uc008ddu.3 
ENSMUST00000040307.6 Marchf9 ENSMUST00000040307.6 membrane associated ring-CH-type finger 9 (from RefSeq NM_001033262.2) ENSMUST00000040307.1 ENSMUST00000040307.2 ENSMUST00000040307.3 ENSMUST00000040307.4 ENSMUST00000040307.5 MARH9_MOUSE March9 NM_001033262 Q3TZ87 Q8VCL1 uc007hhu.1 uc007hhu.2 uc007hhu.3 E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Homodimer. Golgi apparatus membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein The RING-CH-type zinc finger domain is required for E3 ligase activity. Sequence=AAH19560.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane molecular_function lysosome lysosomal membrane Golgi apparatus Golgi stack trans-Golgi network biological_process zinc ion binding membrane integral component of membrane protein ubiquitination transferase activity metal ion binding uc007hhu.1 uc007hhu.2 uc007hhu.3 
ENSMUST00000040312.7 Trib3 ENSMUST00000040312.7 tribbles pseudokinase 3 (from RefSeq NM_175093.2) ENSMUST00000040312.1 ENSMUST00000040312.2 ENSMUST00000040312.3 ENSMUST00000040312.4 ENSMUST00000040312.5 ENSMUST00000040312.6 NM_175093 Nipk Q3UMQ0 Q8K4K2 Q921E7 TRIB3_MOUSE Trb3 uc008nff.1 uc008nff.2 uc008nff.3 Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:17369260). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (By similarity). May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (By similarity). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (PubMed:12749859, PubMed:17369260). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (PubMed:12791994). May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (PubMed:12791994). Interacts with the NF- kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases (By similarity). Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230). Interacts with AKT1, AKT2, MAP2K1 and MAP2K7 (PubMed:12791994). Interacts with ATF4 (PubMed:12749859, PubMed:17369260). Interacts with DDIT3/CHOP and inhibits its interaction with EP300/P300 (By similarity). Interacts with APOBEC3C (By similarity). Interacts (via N-terminus) with APOBEC3A (PubMed:22977230). Interacts with RELA (By similarity). Q8K4K2; P31750: Akt1; NbExp=5; IntAct=EBI-448962, EBI-298707; Q8K4K2; Q06507: Atf4; NbExp=3; IntAct=EBI-448962, EBI-77383; Nucleus Highly expressed in liver. Not detected in heart, brain, spleen, lung, skeletal muscle, kidney or testis. In liver under fasting conditions and by thapsigargin (PubMed:12749859, PubMed:12791994). Expression is activated by ATF4 in response to stress (PubMed:17369260). The protein kinase domain is predicted to be catalytically inactive. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. The role of this protein in Akt activation has been demonstrated in PubMed:12749859 but Iynedjian has not been able to reproduce the result in rat hepatocytes. negative regulation of transcription from RNA polymerase II promoter transcription corepressor activity protein kinase inhibitor activity protein binding ATP binding nucleus nucleolus protein phosphorylation negative regulation of protein kinase activity apoptotic process regulation of autophagy regulation of glucose transport enzyme binding protein kinase binding mitogen-activated protein kinase kinase binding ubiquitin protein ligase binding nuclear membrane positive regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to insulin stimulus response to endoplasmic reticulum stress regulation of MAP kinase activity negative regulation of fat cell differentiation negative regulation of fatty acid biosynthetic process positive regulation of protein catabolic process negative regulation of transcription, DNA-templated positive regulation of ubiquitin-protein transferase activity ubiquitin-protein transferase regulator activity intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress kinase activity uc008nff.1 uc008nff.2 uc008nff.3 
ENSMUST00000040313.6 Bcdin3d ENSMUST00000040313.6 BCDIN3 domain containing (from RefSeq NM_029236.2) BN3D2_MOUSE Bcdin3d ENSMUST00000040313.1 ENSMUST00000040313.2 ENSMUST00000040313.3 ENSMUST00000040313.4 ENSMUST00000040313.5 NM_029236 Q91YP1 Q9D4U5 uc007xpo.1 uc007xpo.2 uc007xpo.3 uc007xpo.4 O-methyltransferase that specifically monomethylates 5'- monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre- miR-145. Reaction=a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L- methionine = a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S- adenosyl-L-homocysteine; Xref=Rhea:RHEA:58656, Rhea:RHEA-COMP:15179, Rhea:RHEA-COMP:15181, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138282, ChEBI:CHEBI:142776; Evidence=; Reaction=a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L- methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S- adenosyl-L-homocysteine; Xref=Rhea:RHEA:58640, Rhea:RHEA-COMP:15179, Rhea:RHEA-COMP:15182, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138282, ChEBI:CHEBI:142777; Evidence=; Interacts with DICER1; the interaction may be mediated by RNA. Cytoplasm Belongs to the methyltransferase superfamily. RNA methylation nucleus cytoplasm cytosol methyltransferase activity O-methyltransferase activity RNA methyltransferase activity tRNA methyltransferase activity miRNA metabolic process transferase activity tRNA methylation methylation miRNA 2'-O-methylation negative regulation of pre-miRNA processing uc007xpo.1 uc007xpo.2 uc007xpo.3 uc007xpo.4 
ENSMUST00000040314.12 Rbm17 ENSMUST00000040314.12 RNA binding motif protein 17, transcript variant 1 (from RefSeq NM_152824.2) A2AP41 ENSMUST00000040314.1 ENSMUST00000040314.10 ENSMUST00000040314.11 ENSMUST00000040314.2 ENSMUST00000040314.3 ENSMUST00000040314.4 ENSMUST00000040314.5 ENSMUST00000040314.6 ENSMUST00000040314.7 ENSMUST00000040314.8 ENSMUST00000040314.9 NM_152824 O75939 Q8JZX4 SPF45_MOUSE Spf45 uc008iio.1 uc008iio.2 uc008iio.3 Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites (By similarity). Binds SXL. Associates with the spliceosome. Interacts with SF3B1, SF1 and U2AF2 (By similarity). Nucleus RNA splicing, via transesterification reactions alternative mRNA splicing, via spliceosome regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding protein binding nucleus nucleoplasm spliceosomal complex DNA repair mRNA processing RNA splicing macromolecular complex regulation of RNA splicing uc008iio.1 uc008iio.2 uc008iio.3 
ENSMUST00000040320.10 Micall1 ENSMUST00000040320.10 microtubule associated monooxygenase, calponin and LIM domain containing -like 1 (from RefSeq NM_177461.2) D15Mit260 E9QKJ4 ENSMUST00000040320.1 ENSMUST00000040320.2 ENSMUST00000040320.3 ENSMUST00000040320.4 ENSMUST00000040320.5 ENSMUST00000040320.6 ENSMUST00000040320.7 ENSMUST00000040320.8 ENSMUST00000040320.9 Kiaa1668 MILK1_MOUSE Mirab13 NM_177461 Q8BGT6 Q8BJ60 uc007wso.1 uc007wso.2 uc007wso.3 uc007wso.4 uc007wso.5 Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth. Homooligomer (Probable). Interacts (via NPF1 motif) with EHD1 (via EH domain); the interaction is direct and probably recruits EHD1 to membranes. Interacts with EHD3 (via EH domain). Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits MICALL1 to membranes. Interacts with ACAP2; the interaction is indirect through RAB35. Interacts with RAB8A (GTP-bound form); regulates RAB8A association with recycling endosomes. Interacts with RAB13 (GTP-bound form). Interacts with ARF6 (GTP-bound form). Interacts with PACSIN2 (via the SH3 domain). Interacts with DPYSL2. Recycling endosome membrane ; Peripheral membrane protein Late endosome membrane Note=Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6 (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BGT6-1; Sequence=Displayed; Name=2; IsoId=Q8BGT6-2; Sequence=VSP_009851; Name=3; IsoId=Q8BGT6-3; Sequence=VSP_009852, VSP_009853; Probably exists in a closed and an opened conformation due to interaction of the C-terminal RAB-binding domain (RBD), also described as bivalent Mical/EHBP Rab binding (bMERB) domain, with the N-terminal calponin-homology (CH) domain. The conformational change is regulated by RAB13 and may modulate MICALL1 interactions with functional partners (By similarity). Sequence=BAC98229.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding endosome late endosome microtubule organizing center protein targeting to membrane endocytosis receptor-mediated endocytosis endosome membrane protein transport membrane Rab GTPase binding extrinsic component of membrane actin cytoskeleton organization neuron projection development late endosome membrane filamentous actin endocytic recycling slow endocytic recycling protein localization to endosome identical protein binding metal ion binding recycling endosome membrane phosphatidic acid binding plasma membrane tubulation cellular response to nerve growth factor stimulus retrograde transport, endosome to plasma membrane uc007wso.1 uc007wso.2 uc007wso.3 uc007wso.4 uc007wso.5 
ENSMUST00000040321.13 Trmt10a ENSMUST00000040321.13 tRNA methyltransferase 10A, transcript variant 1 (from RefSeq NM_175389.6) A0A0R4J205 A0A0R4J205_MOUSE ENSMUST00000040321.1 ENSMUST00000040321.10 ENSMUST00000040321.11 ENSMUST00000040321.12 ENSMUST00000040321.2 ENSMUST00000040321.3 ENSMUST00000040321.4 ENSMUST00000040321.5 ENSMUST00000040321.6 ENSMUST00000040321.7 ENSMUST00000040321.8 ENSMUST00000040321.9 NM_175389 Trmt10a uc008rna.1 uc008rna.2 uc008rna.3 uc008rna.4 Reaction=guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)- methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43156, Rhea:RHEA-COMP:10367, Rhea:RHEA-COMP:10368, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.221; Evidence=; tRNA binding nucleus nucleoplasm nucleolus cytosol methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity actin cytoskeleton tRNA methylation uc008rna.1 uc008rna.2 uc008rna.3 uc008rna.4 
ENSMUST00000040324.14 Ppp1r26 ENSMUST00000040324.14 protein phosphatase 1, regulatory subunit 26, transcript variant 10 (from RefSeq NM_001411201.1) ENSMUST00000040324.1 ENSMUST00000040324.10 ENSMUST00000040324.11 ENSMUST00000040324.12 ENSMUST00000040324.13 ENSMUST00000040324.2 ENSMUST00000040324.3 ENSMUST00000040324.4 ENSMUST00000040324.5 ENSMUST00000040324.6 ENSMUST00000040324.7 ENSMUST00000040324.8 ENSMUST00000040324.9 Gm347 Kiaa0649 NM_001411201 PPR26_MOUSE Q6A025 Q6NS64 uc008iye.1 uc008iye.2 Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation. Interacts with UTP20 and PPP1CA. Nucleus, nucleolus Nude mice injected with Ppp1r26-expressing cells develop tumors within 2 weeks. Sequence=BAD32271.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein phosphatase inhibitor activity nucleus nucleolus negative regulation of phosphatase activity negative regulation of phosphoprotein phosphatase activity uc008iye.1 uc008iye.2 
ENSMUST00000040330.15 Cep44 ENSMUST00000040330.15 centrosomal protein 44 (from RefSeq NM_001009951.1) CEP44_MOUSE ENSMUST00000040330.1 ENSMUST00000040330.10 ENSMUST00000040330.11 ENSMUST00000040330.12 ENSMUST00000040330.13 ENSMUST00000040330.14 ENSMUST00000040330.2 ENSMUST00000040330.3 ENSMUST00000040330.4 ENSMUST00000040330.5 ENSMUST00000040330.6 ENSMUST00000040330.7 ENSMUST00000040330.8 ENSMUST00000040330.9 Kiaa1712 NM_001009951 Q5DTV5 Q5HZK1 uc009lsp.1 uc009lsp.2 uc009lsp.3 Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome. Interacts with CROCC. Interacts with POC1B; the interaction is direct and recruits POC1B to centriolar microtubules. Binds to centriolar microtubules. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle pole Midbody Note=Localizes to the proximal end of mother and daughter centrioles. spindle pole molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton biological_process midbody uc009lsp.1 uc009lsp.2 uc009lsp.3 
ENSMUST00000040336.12 Slc22a23 ENSMUST00000040336.12 solute carrier family 22, member 23, transcript variant 1 (from RefSeq NM_001033167.3) ENSMUST00000040336.1 ENSMUST00000040336.10 ENSMUST00000040336.11 ENSMUST00000040336.2 ENSMUST00000040336.3 ENSMUST00000040336.4 ENSMUST00000040336.5 ENSMUST00000040336.6 ENSMUST00000040336.7 ENSMUST00000040336.8 ENSMUST00000040336.9 NM_001033167 Q3UHH2 Q7TPT5 S22AN_MOUSE uc007qbh.1 uc007qbh.2 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UHH2-1; Sequence=Displayed; Name=2; IsoId=Q3UHH2-2; Sequence=VSP_028957, VSP_028958; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. ion transport membrane integral component of membrane transmembrane transporter activity transmembrane transport uc007qbh.1 uc007qbh.2 
ENSMUST00000040340.16 Fcho2 ENSMUST00000040340.16 FCH domain only 2 (from RefSeq NM_172591.3) ENSMUST00000040340.1 ENSMUST00000040340.10 ENSMUST00000040340.11 ENSMUST00000040340.12 ENSMUST00000040340.13 ENSMUST00000040340.14 ENSMUST00000040340.15 ENSMUST00000040340.2 ENSMUST00000040340.3 ENSMUST00000040340.4 ENSMUST00000040340.5 ENSMUST00000040340.6 ENSMUST00000040340.7 ENSMUST00000040340.8 ENSMUST00000040340.9 FCHO2_MOUSE NM_172591 Q3UJ91 Q3UQN2 Q7TMS9 Q8C0I2 uc033gnc.1 uc033gnc.2 uc033gnc.3 Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2- dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. Homodimer; disulfide-linked (By similarity). May form homotetramer. Interacts with AP2A1. Interacts with EPS15, EPS15R, ITSN1 and ITSN2; recruit those scaffolding proteins which in turn may interact with the adaptor protein complex AP-2 at the plasma membrane. Interacts with DAB2 (via DPF motifs); mediates LDL receptor/LDLR endocytosis. Q3UQN2; Q3UQN2: Fcho2; NbExp=5; IntAct=EBI-6094986, EBI-6094986; Q3UQN2; A7BFV9: Eps15; Xeno; NbExp=2; IntAct=EBI-6094986, EBI-6095043; Q3UQN2; P42566: EPS15; Xeno; NbExp=3; IntAct=EBI-6094986, EBI-396684; Q3UQN2; Q15811: ITSN1; Xeno; NbExp=3; IntAct=EBI-6094986, EBI-602041; Membrane, clathrin-coated pit ; Peripheral membrane protein ytoplasmic side Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UQN2-1; Sequence=Displayed; Name=2; IsoId=Q3UQN2-2; Sequence=VSP_021912, VSP_021913; Name=3; IsoId=Q3UQN2-3; Sequence=VSP_021914, VSP_021915; Ubiquitously expressed (at protein level). Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination. Belongs to the FCHO family. Sequence=AAH52456.1; Type=Erroneous initiation; Evidence=; Sequence=AAH53718.1; Type=Erroneous initiation; Evidence=; Sequence=BAC27226.1; Type=Erroneous initiation; Evidence=; Sequence=BAC27226.1; Type=Frameshift; Evidence=; phosphatidylserine binding protein binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm cytoskeleton plasma membrane clathrin-coated pit endocytosis cytoskeletal protein binding membrane invagination membrane clathrin-coated vesicle phosphatidylinositol binding identical protein binding clathrin coat assembly synaptic vesicle endocytosis clathrin-dependent endocytosis protein localization to plasma membrane presynaptic endocytic zone membrane uc033gnc.1 uc033gnc.2 uc033gnc.3 
ENSMUST00000040344.7 Gns ENSMUST00000040344.7 glucosamine (N-acetyl)-6-sulfatase, transcript variant 1 (from RefSeq NM_029364.4) ENSMUST00000040344.1 ENSMUST00000040344.2 ENSMUST00000040344.3 ENSMUST00000040344.4 ENSMUST00000040344.5 ENSMUST00000040344.6 GNS_MOUSE NM_029364 Q3TWT0 Q8BFR4 Q8BJJ7 Q8BK91 uc007hfo.1 uc007hfo.2 Reaction=Hydrolysis of the 6-sulfate groups of the N-acetyl-D- glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.; EC=3.1.6.14; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Lysosome The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. Belongs to the sulfatase family. catalytic activity glycosaminoglycan binding lysosome N-acetylglucosamine-6-sulfatase activity sulfuric ester hydrolase activity hydrolase activity glycosaminoglycan metabolic process sulfate binding metal ion binding uc007hfo.1 uc007hfo.2 
ENSMUST00000040359.6 Arsi ENSMUST00000040359.6 arylsulfatase i (from RefSeq NM_001038499.2) ARSI_MOUSE ENSMUST00000040359.1 ENSMUST00000040359.2 ENSMUST00000040359.3 ENSMUST00000040359.4 ENSMUST00000040359.5 NM_001038499 Q32KI9 uc008fbe.1 uc008fbe.2 uc008fbe.3 Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Secreted Endoplasmic reticulum Note=Localized in the intracellular granular structures. The oxidation of Cys-93 residue to 3-oxoalanine (also known as C(alpha)-formylglycine) by SUMF1/Sulfatase-modifying factor 1, seems critical for catalytic activity. Belongs to the sulfatase family. catalytic activity cellular_component extracellular region endoplasmic reticulum sulfuric ester hydrolase activity hydrolase activity metal ion binding uc008fbe.1 uc008fbe.2 uc008fbe.3 
ENSMUST00000040361.8 Atp6v0e2 ENSMUST00000040361.8 ATPase, H+ transporting, lysosomal V0 subunit E2, transcript variant 1 (from RefSeq NM_133764.3) ENSMUST00000040361.1 ENSMUST00000040361.2 ENSMUST00000040361.3 ENSMUST00000040361.4 ENSMUST00000040361.5 ENSMUST00000040361.6 ENSMUST00000040361.7 NM_133764 Q91XE7 VA0E2_MOUSE uc009bup.1 uc009bup.2 uc009bup.3 uc009bup.4 uc009bup.5 Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Membrane ; Multi-pass membrane protein Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Belongs to the V-ATPase e1/e2 subunit family. ion transport hydrogen ion transmembrane transporter activity membrane integral component of membrane hydrolase activity proton-transporting V-type ATPase, V0 domain proton-transporting ATPase activity, rotational mechanism transmembrane transport hydrogen ion transmembrane transport uc009bup.1 uc009bup.2 uc009bup.3 uc009bup.4 uc009bup.5 
ENSMUST00000040368.3 Rmdn2 ENSMUST00000040368.3 regulator of microtubule dynamics 2, transcript variant 1 (from RefSeq NM_201361.3) A9UN02 ENSMUST00000040368.1 ENSMUST00000040368.2 Fam82a Fam82a1 NM_201361 Q8BSE0 Q8CIF1 RMD2_MOUSE uc008dpy.1 uc008dpy.2 Interacts with microtubules. Membrane ; Single-pass membrane protein Cytoplasm. Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Also detected as large dots in the perinuclear region (By similarity). Belongs to the RMDN family. Sequence=AAH24059.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; spindle pole molecular_function cytoplasm mitochondrion Golgi apparatus spindle cytosol cytoskeleton microtubule biological_process membrane integral component of membrane mitotic spindle uc008dpy.1 uc008dpy.2 
ENSMUST00000040372.14 Tmem258 ENSMUST00000040372.14 transmembrane protein 258, transcript variant 1 (from RefSeq NM_026919.1) 1810006K21Rik ENSMUST00000040372.1 ENSMUST00000040372.10 ENSMUST00000040372.11 ENSMUST00000040372.12 ENSMUST00000040372.13 ENSMUST00000040372.2 ENSMUST00000040372.3 ENSMUST00000040372.4 ENSMUST00000040372.5 ENSMUST00000040372.6 ENSMUST00000040372.7 ENSMUST00000040372.8 ENSMUST00000040372.9 NM_026919 Q60FD1 Q60FD1_MOUSE Tmem258 uc008gpi.1 uc008gpi.2 uc008gpi.3 uc008gpi.4 Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Component of the oligosaccharyltransferase (OST) complex. Membrane ulti-pass membrane protein Belongs to the OST5 family. endoplasmic reticulum protein N-linked glycosylation membrane integral component of membrane oligosaccharyltransferase I complex uc008gpi.1 uc008gpi.2 uc008gpi.3 uc008gpi.4 
ENSMUST00000040374.6 A930018P22Rik ENSMUST00000040374.6 RIKEN cDNA A930018P22 gene (from RefSeq NM_026634.2) CK091_MOUSE ENSMUST00000040374.1 ENSMUST00000040374.2 ENSMUST00000040374.3 ENSMUST00000040374.4 ENSMUST00000040374.5 NM_026634 Q9D1Z2 uc008ljp.1 uc008ljp.2 uc008ljp.3 molecular_function biological_process uc008ljp.1 uc008ljp.2 uc008ljp.3 
ENSMUST00000040381.15 Ncoa5 ENSMUST00000040381.15 nuclear receptor coactivator 5 (from RefSeq NM_144892.1) A2A5L2 ENSMUST00000040381.1 ENSMUST00000040381.10 ENSMUST00000040381.11 ENSMUST00000040381.12 ENSMUST00000040381.13 ENSMUST00000040381.14 ENSMUST00000040381.2 ENSMUST00000040381.3 ENSMUST00000040381.4 ENSMUST00000040381.5 ENSMUST00000040381.6 ENSMUST00000040381.7 ENSMUST00000040381.8 ENSMUST00000040381.9 NCOA5_MOUSE NM_144892 Q91W39 uc008nwv.1 uc008nwv.2 uc008nwv.3 Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2) (By similarity). Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA (By similarity). Nucleus Expressed in both unfertilized and fertilized eggs during preimplantation development (at protein level) (PubMed:24268775). Detected in all blastmeres of morulae at 3 days post-coitum (dpc) (at protein level) (PubMed:24268775). Localizes to the pluripotent inner cell mass (ICM) of blastocysts at 4 dpc (at protein level) (PubMed:24268775). Expressed in many fetal tissues (PubMed:11113208). High expression in fetal heart and kidney (PubMed:11113208). Weak expression in fetal liver (PubMed:11113208). Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors. chromatin binding nucleus actin cytoskeleton glucose homeostasis negative regulation of insulin receptor signaling pathway uc008nwv.1 uc008nwv.2 uc008nwv.3 
ENSMUST00000040383.9 Cc2d1a ENSMUST00000040383.9 coiled-coil and C2 domain containing 1A, transcript variant 1 (from RefSeq NM_145970.2) C2D1A_MOUSE ENSMUST00000040383.1 ENSMUST00000040383.2 ENSMUST00000040383.3 ENSMUST00000040383.4 ENSMUST00000040383.5 ENSMUST00000040383.6 ENSMUST00000040383.7 ENSMUST00000040383.8 NM_145970 Q2MJB5 Q8K1A6 Q8R3Z4 uc009mma.1 uc009mma.2 uc009mma.3 Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Cytoplasm Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Highly expressed in brain, expression is enriched in the gray matter and strongest in the olfactory bulb. Expressed at 12 dpc throughout the ventricular zone and developing cortical plate and ganglionic eminences. At 16 dpc detected throughout the brain but most strongly in the cortical plate. At postnatal day 3 expressed widely with strong expression in cerebral cortex and hippocampus. The C2 domain is required for the repression. Knockout mice die soon after birth, apparently because of their inability to breathe. Belongs to the CC2D1 family. Sequence=AAH16188.1; Type=Erroneous initiation; Evidence=; Sequence=AAH27028.1; Type=Erroneous initiation; Evidence=; Sequence=ABC56419.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding fibrillar center DNA binding nucleus cytoplasm microtubule organizing center cytosol cytoskeleton plasma membrane uc009mma.1 uc009mma.2 uc009mma.3 
ENSMUST00000040402.14 Ppp1r11 ENSMUST00000040402.14 protein phosphatase 1, regulatory inhibitor subunit 11 (from RefSeq NM_029632.3) A5A4Y9 A5A4Y9_MOUSE ENSMUST00000040402.1 ENSMUST00000040402.10 ENSMUST00000040402.11 ENSMUST00000040402.12 ENSMUST00000040402.13 ENSMUST00000040402.2 ENSMUST00000040402.3 ENSMUST00000040402.4 ENSMUST00000040402.5 ENSMUST00000040402.6 ENSMUST00000040402.7 ENSMUST00000040402.8 ENSMUST00000040402.9 NM_029632 Ppp1r11 uc008cln.1 uc008cln.2 uc008cln.3 uc008cln.4 Interacts with TLR2 and UBE2D2. protein serine/threonine phosphatase inhibitor activity ubiquitin-dependent protein catabolic process protein ubiquitination negative regulation of phosphoprotein phosphatase activity ubiquitin protein ligase activity uc008cln.1 uc008cln.2 uc008cln.3 uc008cln.4 
ENSMUST00000040404.8 Ly6d ENSMUST00000040404.8 lymphocyte antigen 6 family member D (from RefSeq NM_010742.1) ENSMUST00000040404.1 ENSMUST00000040404.2 ENSMUST00000040404.3 ENSMUST00000040404.4 ENSMUST00000040404.5 ENSMUST00000040404.6 ENSMUST00000040404.7 LY6D_MOUSE Ly61 NM_010742 P35459 Thb uc007wfx.1 uc007wfx.2 uc007wfx.3 May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. Cell membrane ; Lipid-anchor, GPI- anchor Lymphoid cells lacking Ly6d, called ALP (all- lymphoid progenitor), retain full lymphoid potential and early thymic seeding activity, whereas cells containing Ly6d, called BLP (B-cell- biased lymphoid progenitor), up-regulate the B-cell specifying factors Ebf1 and Pax5 and behave essentially as B-cell progenitors (at protein level). Thymocytes and B-cells. Sequence=AAA79249.1; Type=Erroneous initiation; Evidence=; plasma membrane cell surface membrane lymphocyte differentiation anchored component of membrane response to stilbenoid uc007wfx.1 uc007wfx.2 uc007wfx.3 
ENSMUST00000040411.7 Rab42 ENSMUST00000040411.7 RAB42, member RAS oncogene family (from RefSeq NM_001081651.1) ENSMUST00000040411.1 ENSMUST00000040411.2 ENSMUST00000040411.3 ENSMUST00000040411.4 ENSMUST00000040411.5 ENSMUST00000040411.6 NM_001081651 Q0PD08 RAB42_MOUSE Rab42 Rab43 uc008vay.1 uc008vay.2 uc008vay.3 Membrane ; Lipid- anchor Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity GTP binding cell intracellular protein transport membrane Rab protein signal transduction uc008vay.1 uc008vay.2 uc008vay.3 
ENSMUST00000040416.8 Ddx19a ENSMUST00000040416.8 DEAD box helicase 19a, transcript variant 1 (from RefSeq NM_007916.2) DD19A_MOUSE Ddx19 ENSMUST00000040416.1 ENSMUST00000040416.2 ENSMUST00000040416.3 ENSMUST00000040416.4 ENSMUST00000040416.5 ENSMUST00000040416.6 ENSMUST00000040416.7 Eif4a-rs1 NM_007916 Q543M2 Q61655 Q921R0 uc009nll.1 uc009nll.2 uc009nll.3 uc009nll.4 ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Cytoplasm Nucleus, nucleoplasm Note=Associates with the nuclear pore complex cytoplasmic fibrils. Found in testis, heart, brain, liver, skeletal muscle, and kidney. The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis. Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus nuclear pore cytoplasm cytoplasmic stress granule protein transport membrane hydrolase activity poly(A)+ mRNA export from nucleus nuclear membrane positive regulation of apoptotic process mRNA transport uc009nll.1 uc009nll.2 uc009nll.3 uc009nll.4 
ENSMUST00000040418.9 Chad ENSMUST00000040418.9 chondroadherin (from RefSeq NM_007689.5) Chad ENSMUST00000040418.1 ENSMUST00000040418.2 ENSMUST00000040418.3 ENSMUST00000040418.4 ENSMUST00000040418.5 ENSMUST00000040418.6 ENSMUST00000040418.7 ENSMUST00000040418.8 NM_007689 Q3TYW1 Q3TYW1_MOUSE uc007kzd.1 uc007kzd.2 uc007kzd.3 uc007kzd.1 uc007kzd.2 uc007kzd.3 
ENSMUST00000040421.11 Coq5 ENSMUST00000040421.11 coenzyme Q5 methyltransferase, transcript variant 2 (from RefSeq NR_184540.1) COQ5_MOUSE Coq5 D5Ertd33e ENSMUST00000040421.1 ENSMUST00000040421.10 ENSMUST00000040421.2 ENSMUST00000040421.3 ENSMUST00000040421.4 ENSMUST00000040421.5 ENSMUST00000040421.6 ENSMUST00000040421.7 ENSMUST00000040421.8 ENSMUST00000040421.9 NR_184540 Q9CXI0 Q9D6Y6 Q9D900 uc008zdo.1 uc008zdo.2 uc008zdo.3 Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). Reaction=a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S- adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl- 1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:28286, Rhea:RHEA-COMP:10858, Rhea:RHEA-COMP:10859, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:84166, ChEBI:CHEBI:84167; EC=2.1.1.201; Evidence=; Cofactor biosynthesis; ubiquinone biosynthesis. Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with PYURF; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex (By similarity). Mitochondrion inner membrane eripheral membrane protein atrix side Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family. Sequence=BAB26525.1; Type=Frameshift; Evidence=; mitochondrion mitochondrial inner membrane mitochondrial matrix ubiquinone biosynthetic process methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity membrane transferase activity extrinsic component of mitochondrial inner membrane methylation macromolecular complex 2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity uc008zdo.1 uc008zdo.2 uc008zdo.3 
ENSMUST00000040423.12 Cd59a ENSMUST00000040423.12 CD59a antigen, transcript variant 2 (from RefSeq NM_007652.6) CD59A_MOUSE Cd59 ENSMUST00000040423.1 ENSMUST00000040423.10 ENSMUST00000040423.11 ENSMUST00000040423.2 ENSMUST00000040423.3 ENSMUST00000040423.4 ENSMUST00000040423.5 ENSMUST00000040423.6 ENSMUST00000040423.7 ENSMUST00000040423.8 ENSMUST00000040423.9 NM_007652 O55186 Q542R7 uc008ljo.1 uc008ljo.2 uc008ljo.3 uc008ljo.4 uc008ljo.5 Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity). Cell membrane; Lipid-anchor, GPI-anchor. Expressed in all tissues examined (liver, kidney, spleen, thymus, brain and heart). Low levels in thymus. Also expressed in mononuclear cells, erythrocytes and platelets. Barely detected in neutrophils. complement binding negative regulation of activation of membrane attack complex plasma membrane external side of plasma membrane cell surface membrane negative regulation of angiogenesis regulation of complement activation negative regulation of vascular endothelial growth factor receptor signaling pathway anchored component of membrane negative regulation of complement activation negative regulation of fibroblast growth factor production regulation of complement-dependent cytotoxicity uc008ljo.1 uc008ljo.2 uc008ljo.3 uc008ljo.4 uc008ljo.5 
ENSMUST00000040428.4 Rnasek ENSMUST00000040428.4 ribonuclease, RNase K (from RefSeq NM_173742.3) D11Bwg0434e ENSMUST00000040428.1 ENSMUST00000040428.2 ENSMUST00000040428.3 NM_173742 Q3TAB4 Q8K3C0 RNK_MOUSE uc007jui.1 uc007jui.2 uc007jui.3 uc007jui.4 Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate (By similarity). Regulates the activity of vacuolar (H+)-ATPase (V-ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity). Required at an early stage of receptor-mediated endocytosis (By similarity). Interacts with the proton translocation complex V0 of the V- ATPase (By similarity). Interacts with ATP6AP1 (By similarity). Endomembrane system ; Multi-pass membrane protein Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Multi-pass membrane protein Belongs to the RNase K family. nuclease activity endonuclease activity endoribonuclease activity cellular_component membrane integral component of membrane hydrolase activity nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc007jui.1 uc007jui.2 uc007jui.3 uc007jui.4 
ENSMUST00000040430.8 Vat1 ENSMUST00000040430.8 vesicle amine transport 1 (from RefSeq NM_012037.2) ENSMUST00000040430.1 ENSMUST00000040430.2 ENSMUST00000040430.3 ENSMUST00000040430.4 ENSMUST00000040430.5 ENSMUST00000040430.6 ENSMUST00000040430.7 NM_012037 Q62465 Q8R3G0 Q8R3T8 VAT1_MOUSE Vat-1 uc007loz.1 uc007loz.2 uc007loz.3 Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (By similarity). Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is localized in the cytoplasm a small amount is associated with mitochondria. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. cytoplasm mitochondrion mitochondrial outer membrane zinc ion binding negative regulation of mitochondrial fusion membrane oxidoreductase activity oxidation-reduction process uc007loz.1 uc007loz.2 uc007loz.3 
ENSMUST00000040434.9 Tbcc ENSMUST00000040434.9 tubulin-specific chaperone C (from RefSeq NM_178385.3) A0A0R4J0M1 A0A0R4J0M1_MOUSE ENSMUST00000040434.1 ENSMUST00000040434.2 ENSMUST00000040434.3 ENSMUST00000040434.4 ENSMUST00000040434.5 ENSMUST00000040434.6 ENSMUST00000040434.7 ENSMUST00000040434.8 NM_178385 Tbcc uc008cum.1 uc008cum.2 uc008cum.3 Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cytoplasm Belongs to the TBCC family. nucleotide binding cell morphogenesis GTPase activity GTP binding cytoplasm cytosol post-chaperonin tubulin folding pathway tubulin binding photoreceptor connecting cilium uc008cum.1 uc008cum.2 uc008cum.3 
ENSMUST00000040437.6 Spaca5 ENSMUST00000040437.6 sperm acrosome associated 5 (from RefSeq NM_001085393.3) A2AE20 ENSMUST00000040437.1 ENSMUST00000040437.2 ENSMUST00000040437.3 ENSMUST00000040437.4 ENSMUST00000040437.5 Gm718 LYZL5_MOUSE Lyzl5 NM_001085393 uc009sul.1 uc009sul.2 uc009sul.3 uc009sul.4 Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17; Secreted Belongs to the glycosyl hydrolase 22 family. lysozyme activity extracellular region metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds defense response to Gram-negative bacterium defense response to Gram-positive bacterium uc009sul.1 uc009sul.2 uc009sul.3 uc009sul.4 
ENSMUST00000040440.7 Calm2 ENSMUST00000040440.7 calmodulin 2, transcript variant 1 (from RefSeq NM_007589.5) CALM3_MOUSE Calm3 Cam3 Camc ENSMUST00000040440.1 ENSMUST00000040440.2 ENSMUST00000040440.3 ENSMUST00000040440.4 ENSMUST00000040440.5 ENSMUST00000040440.6 NM_007589 P02593 P0DP28 P62204 P70667 P99014 Q3TEH7 Q3THK5 Q3U6Z5 Q3U7C7 Q498A3 Q61379 Q61380 Q8BNC9 Q91VQ9 Q9D6G4 uc008dux.1 uc008dux.2 uc008dux.3 uc008dux.4 Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin- dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Interacts with CEP97, CCP110, MYO1C, TTN/titin and SRY. Interacts with MYO10. Interacts with RRAD (By similarity). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2. Interacts with SCN5A (By similarity). Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with RYR1 (PubMed:18650434). Interacts with MYO5A (By similarity). Interacts with IQCF1 (PubMed:25380116). Interacts with SYT7 (PubMed:24569478). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity). Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:18650434). Interacts with PCP4; regulates calmodulin calcium- binding (By similarity). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel (By similarity). Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. Ubiquitination results in a strongly decreased activity. Phosphorylation results in a decreased activity. This protein has four functional calcium-binding sites. Belongs to the calmodulin family. Sequence=BAC39089.2; Type=Erroneous translation; Note=Wrong CDS prediction.; Evidence=; G2/M transition of mitotic cell cycle spindle pole response to amphetamine regulation of heart rate calcium ion binding detection of calcium ion nucleus cytoplasm centrosome spindle cytoskeleton spindle microtubule plasma membrane activation of adenylate cyclase activity voltage-gated potassium channel complex adenylate cyclase binding adenylate cyclase activator activity regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum calcium-mediated signaling protein kinase binding protein domain specific binding sarcomere nitric-oxide synthase regulator activity growth cone synaptic vesicle membrane titin binding type 3 metabotropic glutamate receptor binding mitochondrial membrane N-terminal myristoylation domain binding regulation of cytokinesis positive regulation of phosphoprotein phosphatase activity macromolecular complex calcium channel complex positive regulation of protein dephosphorylation neuron projection myelin sheath phosphatidylinositol 3-kinase binding ion channel binding metal ion binding protein N-terminus binding calcium-dependent protein binding nitric-oxide synthase binding positive regulation of nitric-oxide synthase activity positive regulation of cyclic-nucleotide phosphodiesterase activity response to corticosterone response to calcium ion regulation of cardiac muscle contraction regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity protein phosphatase activator activity positive regulation by host of symbiont cAMP-mediated signal transduction establishment of protein localization to membrane establishment of protein localization to mitochondrial membrane disordered domain specific binding regulation of synaptic vesicle endocytosis regulation of high voltage-gated calcium channel activity catalytic complex regulation of synaptic vesicle exocytosis uc008dux.1 uc008dux.2 uc008dux.3 uc008dux.4 
ENSMUST00000040442.6 Aox4 ENSMUST00000040442.6 aldehyde oxidase 4 (from RefSeq NM_023631.2) AOXD_MOUSE Aoh2 ENSMUST00000040442.1 ENSMUST00000040442.2 ENSMUST00000040442.3 ENSMUST00000040442.4 ENSMUST00000040442.5 NM_023631 Q3TYQ9 Q8VI17 uc007bbo.1 uc007bbo.2 uc007bbo.3 Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Is responsible for the major all-trans- retinaldehyde-metabolizing activity in the Harderian gland, and contributes a significant amount of the same activity in the skin. Is devoid of pyridoxal-oxidizing activity, in contrast to the other aldehyde oxidases. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles. Reaction=an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2; Xref=Rhea:RHEA:16829, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067; EC=1.2.3.1; Evidence=; Reaction=H2O + O2 + retinal = H(+) + H2O2 + retinoate; Xref=Rhea:RHEA:56736, ChEBI:CHEBI:15035, ChEBI:CHEBI:15036, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; Evidence=; Reaction=all-trans-retinal + H2O + O2 = all-trans-retinoate + H(+) + H2O2; Xref=Rhea:RHEA:22520, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291; EC=1.2.3.1; Evidence=; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 2 [2Fe-2S] clusters per subunit. ; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Evidence=; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. ; Kinetic parameters: KM=4.8 uM for all-trans-retinal (at 37 degrees Celsius and pH 7.4) ; Vmax=0.06 umol/min/mg enzyme with all-trans-retinal as substrate (at 37 degrees Celsius and pH 7.4) ; Homodimer. Cytoplasm Highly expressed in Harderian glands and sebaceous glands with detectable levels in the epidermis and other keratinized epithelia (at protein level). Detected in testis. The expression is 3 times greater in females than in males. Repressed by testosterone in Harderian glands. In skin, induced by UVB light. Mice are viable, fertile and born at the expected Mendelian rate. However, they show a deficiency of retinoic acid synthesis in both the Harderian gland and skin. The Harderian gland's transcriptome of knockout mice demonstrates overall down-regulation of direct retinoid-dependent genes as well as perturbations in pathways controlling lipid homeostasis and cellular secretion, particularly in sexually immature animals. The skin is characterized by thickening of the epidermis in basal conditions and after UVB light exposure. AOX genes evolved from a xanthine oxidoreductase ancestral precursor via a series of gene duplication and suppression/deletion events. Different animal species contain a different complement of AOX genes encoding an equivalent number of AOX isoenzymes. In mammals, the two extremes are represented by certain rodents such as mice and rats, which are endowed with 4 AOX genes, and by humans, whose genome is characterized by a single active gene (PubMed:23263164). Belongs to the xanthine dehydrogenase family. aldehyde oxidase activity xanthine dehydrogenase activity iron ion binding cytoplasm cytosol electron carrier activity xanthine catabolic process oxidoreductase activity drug metabolic process electron transport chain molybdenum ion binding protein homodimerization activity molybdopterin cofactor binding metal ion binding retinal oxidase activity flavin adenine dinucleotide binding NAD binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding oxidation-reduction process FAD binding uc007bbo.1 uc007bbo.2 uc007bbo.3 
ENSMUST00000040445.9 Thap11 ENSMUST00000040445.9 THAP domain containing 11 (from RefSeq NM_021513.2) ENSMUST00000040445.1 ENSMUST00000040445.2 ENSMUST00000040445.3 ENSMUST00000040445.4 ENSMUST00000040445.5 ENSMUST00000040445.6 ENSMUST00000040445.7 ENSMUST00000040445.8 MNCb-2032 NM_021513 Q3TCZ5 Q99KZ0 Q9JJD0 THA11_MOUSE uc009nei.1 uc009nei.2 uc009nei.3 uc009nei.4 Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers. Interacts (via coiled coil domain) with HCFC1. Nucleus Cytoplasm Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus. Mainly restricted to pluripotent cells of the developing embryo, to oocytes, and to certain regions of the adult brain. First appears at the 2-cell stage, intensifies during the 8-cell and compact morula stages, but subsides in the blastocyst. Mice show periimplantational lethality and have defects in the inner cell mass. Conditional knockout prevents the growth of ES cells while forced expression allows ES cells to proliferate without differentiation under conditions that normally do not promote self-renewal. Was named 'Ronin' (a masterless Japanese samurai) by PubMed:18585351 because of its lack of apparent relationship to known 'master' regulator of pluripotency. Belongs to the THAP11 family. Sequence=AAH03949.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus nucleoplasm cytoplasm zinc ion binding intercellular bridge metal ion binding uc009nei.1 uc009nei.2 uc009nei.3 uc009nei.4 
ENSMUST00000040454.5 Bbs10 ENSMUST00000040454.5 Bardet-Biedl syndrome 10 (from RefSeq NM_027914.1) BBS10_MOUSE ENSMUST00000040454.1 ENSMUST00000040454.2 ENSMUST00000040454.3 ENSMUST00000040454.4 NM_027914 Q9DBI2 uc011xnf.1 uc011xnf.2 uc011xnf.3 Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation. Component of a complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 and CCT8. Cell projection, cilium Note=Located within the basal body of the primary cilium of differentiating preadipocytes. Belongs to the TCP-1 chaperonin family. Sequence=BAB23682.1; Type=Miscellaneous discrepancy; Note=Intron retention. Several introns.; Evidence=; nucleotide binding RNA polymerase II repressing transcription factor binding retina homeostasis ATP binding cellular_component cilium cell projection regulation of protein complex assembly photoreceptor cell maintenance chaperone-mediated protein complex assembly non-motile cilium assembly uc011xnf.1 uc011xnf.2 uc011xnf.3 
ENSMUST00000040455.5 Hif1an ENSMUST00000040455.5 hypoxia-inducible factor 1, alpha subunit inhibitor (from RefSeq NM_176958.3) A1L3B7 ENSMUST00000040455.1 ENSMUST00000040455.2 ENSMUST00000040455.3 ENSMUST00000040455.4 HIF1N_MOUSE NM_176958 Q3U3G4 Q8BLR9 uc008hpy.1 uc008hpy.2 uc008hpy.3 Hydroxylates HIF-1 alpha at 'Asn-799' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation (By similarity). Positively regulates ASB4 activity, promoting vascular differentiation. Reaction=2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 = (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate; Xref=Rhea:RHEA:54268, Rhea:RHEA-COMP:13833, Rhea:RHEA-COMP:13834, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50347, ChEBI:CHEBI:138107; EC=1.14.11.30; Reaction=2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate; Xref=Rhea:RHEA:54264, Rhea:RHEA-COMP:13836, Rhea:RHEA- COMP:13837, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29979, ChEBI:CHEBI:30031, ChEBI:CHEBI:138021; EC=1.14.11.n4; Reaction=2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate; Xref=Rhea:RHEA:54272, Rhea:RHEA-COMP:13838, Rhea:RHEA-COMP:13839, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50347, ChEBI:CHEBI:138107; EC=1.14.11.n4; Reaction=2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate; Xref=Rhea:RHEA:54280, Rhea:RHEA-COMP:13843, Rhea:RHEA- COMP:13844, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29961, ChEBI:CHEBI:30031, ChEBI:CHEBI:138111; EC=1.14.11.n4; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Homodimer; homodimerization is essential for catalytic activity. Interacts with VHL and HIF1A. Part of a complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA. Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4. Interacts with ABPA3. Interacts with TNKS2. Interacts with PPP1R12A (By similarity). Interacts with UBE3A (By similarity). Interacts with ASB4. Interacts with ANKS3 (PubMed:25671767). Interacts with NECAB3; the interaction is indirect and seems to be mediated by APBA3 (By similarity). Nucleus Cytoplasm Cytoplasm, perinuclear region Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BLR9-1; Sequence=Displayed; Name=2; IsoId=Q8BLR9-2; Sequence=VSP_017537, VSP_017538; Notch binding iron ion binding protein binding nucleus nucleoplasm cytoplasm cytosol zinc ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors carboxylic acid binding peptidyl-histidine hydroxylation peptidyl-histidine dioxygenase activity peptidyl-asparagine 3-dioxygenase activity peptidyl-aspartic acid hydroxylation peptidyl-asparagine hydroxylation protein homodimerization activity positive regulation of myoblast differentiation negative regulation of Notch signaling pathway metal ion binding cofactor binding perinuclear region of cytoplasm NF-kappaB binding dioxygenase activity oxidation-reduction process negative regulation of transcription from RNA polymerase II promoter in response to hypoxia ankyrin repeat binding uc008hpy.1 uc008hpy.2 uc008hpy.3 
ENSMUST00000040461.4 Flvcr2 ENSMUST00000040461.4 feline leukemia virus subgroup C cellular receptor 2 (from RefSeq NM_145447.2) A0A0R4J0E9 A0A0R4J0E9_MOUSE ENSMUST00000040461.1 ENSMUST00000040461.2 ENSMUST00000040461.3 Flvcr2 Mfsd7c NM_145447 uc007ohe.1 uc007ohe.2 Membrane ; Multi- pass membrane protein integral component of plasma membrane heme transporter activity heme transport membrane integral component of membrane heme binding transmembrane transport uc007ohe.1 uc007ohe.2 
ENSMUST00000040465.11 Clca2 ENSMUST00000040465.11 chloride channel accessory 2, transcript variant 1 (from RefSeq NM_178697.6) CLCA2_MOUSE Clca5 ENSMUST00000040465.1 ENSMUST00000040465.10 ENSMUST00000040465.2 ENSMUST00000040465.3 ENSMUST00000040465.4 ENSMUST00000040465.5 ENSMUST00000040465.6 ENSMUST00000040465.7 ENSMUST00000040465.8 ENSMUST00000040465.9 NM_178697 Q8BG22 Q8BZF7 uc008rqg.1 uc008rqg.2 uc008rqg.3 This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. Mice lacking a functional copy of this gene exhibit increased liver weight and hepatocyte hypertrophy. [provided by RefSeq, Sep 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC096379.1, AK028704.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. Cell membrane ; Single-pass type I membrane protein Basal cell membrane ; Single-pass type I membrane protein Cell junction Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BG22-1; Sequence=Displayed; Name=2; IsoId=Q8BG22-2; Sequence=VSP_033515; Highly expressed in eye, spleen, lung, kidney, uterus, and endothelial cells. Weakly expressed in heart and throughout the gastrointestinal tract. Highly expressed in mammary cell lines. Its expression in immortalized cell line HC11 correlates with slow or arrested growth. Re-expression in mammary tumor cells reduces colony survival. By 30-fold when cells are deprived of growth factors or anchorage in mammary epithelial cell. Down-regulated in metastatic mammary tumor cell lines. The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates. The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N-terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. N-glycosylated. Belongs to the CLCR family. intracellular calcium activated chloride channel activity chloride channel activity nucleus cytosol plasma membrane integral component of plasma membrane proteolysis ion transport chloride transport cell adhesion peptidase activity metallopeptidase activity basal plasma membrane ligand-gated ion channel activity membrane integral component of membrane hydrolase activity cell junction nuclear membrane ion transmembrane transport metal ion binding chloride transmembrane transport uc008rqg.1 uc008rqg.2 uc008rqg.3 
ENSMUST00000040467.15 H2-T5 ENSMUST00000040467.15 histocompatibility 2, T region locus 26 (from RefSeq NM_001081032.3) A7VMS6 A7VMS6_MOUSE EG667977 ENSMUST00000040467.1 ENSMUST00000040467.10 ENSMUST00000040467.11 ENSMUST00000040467.12 ENSMUST00000040467.13 ENSMUST00000040467.14 ENSMUST00000040467.2 ENSMUST00000040467.3 ENSMUST00000040467.4 ENSMUST00000040467.5 ENSMUST00000040467.6 ENSMUST00000040467.7 ENSMUST00000040467.8 ENSMUST00000040467.9 Gm8909 H2-T26 H2-T5 NM_001081032 uc012asn.1 uc012asn.2 uc012asn.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc012asn.1 uc012asn.2 uc012asn.3 
ENSMUST00000040468.16 Primpol ENSMUST00000040468.16 primase and polymerase (DNA-directed), transcript variant 1 (from RefSeq NM_001001184.2) ENSMUST00000040468.1 ENSMUST00000040468.10 ENSMUST00000040468.11 ENSMUST00000040468.12 ENSMUST00000040468.13 ENSMUST00000040468.14 ENSMUST00000040468.15 ENSMUST00000040468.2 ENSMUST00000040468.3 ENSMUST00000040468.4 ENSMUST00000040468.5 ENSMUST00000040468.6 ENSMUST00000040468.7 ENSMUST00000040468.8 ENSMUST00000040468.9 NM_001001184 PRIPO_MOUSE Primpol Q6P1E7 Q8BSR3 uc291zso.1 uc291zso.2 DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them (PubMed:26926109, PubMed:29073063). Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions (By similarity). Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (By similarity). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesions, such as ultraviolet (UV) lesions, R-loops and G- quadruplexes, to allow DNA replication to continue (By similarity). Can also realign primers ahead of 'unreadable lesions' such as abasic sites and 6-4 photoproduct (6-4 pyrimidine-pyrimidinone), thereby skipping the lesion (By similarity). Also able to incorporate nucleotides opposite DNA lesions such as 8oxoG, like a regular translesion synthesis DNA polymerase (By similarity). Also required for reinitiating stalled forks after UV damage during nuclear DNA replication (By similarity). Required for mitochondrial DNA (mtDNA) synthesis and replication, by reinitiating synthesis after UV damage or in the presence of chain-terminating nucleotides (PubMed:29073063). Prevents APOBEC family-mediated DNA mutagenesis by repriming downstream of abasic site to prohibit error-prone translesion synthesis (PubMed:26926109). Has non-overlapping function with POLH (By similarity). In addition to its role in DNA damage response, also required to maintain efficient nuclear and mitochondrial DNA replication in unperturbed cells (By similarity). Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Can act both with Mn(2+) and Mg(2+) as cofactor in vitro, but Mn(2+) is the preferred cofactor in vivo. The polymerase activity incorporates correct dNTPs with much higher efficiency with Mn(2+) than with Mg(2+). The fidelity is slightly more accurate when Mg(2+) is the cofactor compared to Mn(2+). In the presence of Mn(2+), a conformational transition step from non-productive to productive PRIMPOL:DNA complexes limits the enzymatic turnover, whereas in the presence of Mg(2+), the chemical step becomes rate limiting. ; Interacts with RPA1; leading to recruitment to chromatin and stimulate DNA primase activity. Interacts with SSBP1. Interacts with POLDIP2; leading to enhance DNA polymerase activity. Nucleus Mitochondrion matrix Chromosome Note=Present in the nucleus, but a larger fraction is localized inside mitochondria. Associates with nuclear chromatin during the G1 and S phases of unperturbed cell cycles. Recruited to stalled replication forks following interaction with RPA1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P1E7-1; Sequence=Displayed; Name=2; IsoId=Q6P1E7-2; Sequence=VSP_023420, VSP_023421; The zinc knuckle motif binds zinc and is required for the DNA primase activity. It facilitates the binding and selection of the 5'- nucleotide of the newly synthesized primer and the recognition of preferred initiation sites. The RPA1-binding motifs (RBM) mediate interaction with RPA1 and are essential for recruitment to chromatin. The interaction is primarily mediated by RPA1-binding motif 1, which binds to the basic cleft of RPA1, with motif 2 plays a supporting role in RPA1-binding. The presence of an Asp-Aaa-Glu (DxE) motif in the metal-binding active site favors the use of Mn(2+) ions to achieve optimal incoming nucleotide stabilization, especially required during primer synthesis. Glu-116 is required to stabilize the incoming nucleotide at the 3'- site. Mice are viable but show defects in mitochondrial DNA synthesis. Belongs to the eukaryotic-type primase small subunit family. chromatin binding DNA-directed DNA polymerase activity DNA primase activity DNA-directed 5'-3' RNA polymerase activity nucleus mitochondrion mitochondrial matrix mitochondrial DNA replication DNA replication, synthesis of RNA primer DNA repair cellular response to DNA damage stimulus response to UV transferase activity nucleotidyltransferase activity translesion synthesis replication fork processing RNA biosynthetic process uc291zso.1 uc291zso.2 
ENSMUST00000040477.4 Gsx2 ENSMUST00000040477.4 GS homeobox 2 (from RefSeq NM_133256.2) ENSMUST00000040477.1 ENSMUST00000040477.2 ENSMUST00000040477.3 GSX2_MOUSE Gsh-2 Gsh2 NM_133256 P31316 uc008xtx.1 uc008xtx.2 Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development (PubMed:7619729). During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (PubMed:19709628). Nucleus. At 10.0 dpc, expressed in a band of primitive neuroepithelial cells in the neural tube, mesencephalon and telencephalon. At 11.5-13.5 dpc, expression is symmetrical, but tightly limited in areas of the forebrain, midbrain and hindbrain (PubMed:7619729). At 11 dpc, in the developing telencephalon, expressed at high levels in cells throughout the presumptive lateral ganglionic eminence (LGE), with an apparent ventral-to-dorsal gradient in expressing cell numbers. Positive cells are also scattered somewhat uniformly throughout the adjacent medial ganglionic eminence. At 12.5 dpc onward, exhibits a clear graded pattern of expression, with low levels found in cells located ventrally and the highest levels confined to those in the most dorsal portion of the LGE (at protein level) (PubMed:19709628). Expression decreases from 14.5 dpc on and becomes undetectable at 16.5 dpc (PubMed:7619729). Belongs to the Antp homeobox family. regulation of respiratory gaseous exchange by neurological system process DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development pattern specification process central nervous system development brain development spinal cord association neuron differentiation subpallium development hindbrain morphogenesis forebrain dorsal/ventral pattern formation olfactory bulb interneuron differentiation telencephalon regionalization regulation of cell migration sequence-specific DNA binding positive regulation of Notch signaling pathway neuron fate commitment neuron fate specification positive regulation of oligodendrocyte differentiation forebrain morphogenesis subpallium neuron fate commitment uc008xtx.1 uc008xtx.2 
ENSMUST00000040481.4 Slc38a7 ENSMUST00000040481.4 solute carrier family 38, member 7, transcript variant 1 (from RefSeq NM_172758.5) ENSMUST00000040481.1 ENSMUST00000040481.2 ENSMUST00000040481.3 NM_172758 Q3TBN9 Q8BWH0 Q8K2B1 S38A7_MOUSE Slc38a7 Snat7 uc009mzg.1 uc009mzg.2 uc009mzg.3 Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation (PubMed:21511949, PubMed:28416685). The transport activity requires an acidic lysosomal lumen (By similarity). Reaction=L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out); Xref=Rhea:RHEA:68236, ChEBI:CHEBI:29101, ChEBI:CHEBI:58359; Evidence=; Reaction=L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out); Xref=Rhea:RHEA:71383, ChEBI:CHEBI:29101, ChEBI:CHEBI:58048; Evidence=; Interacts with the mTORC1 complex; this interaction mediates the recruitment of mTORC1 to the lysosome and its subsequent activation. Lysosome membrane ; Multi-pass membrane protein Cell projection, axon Note=In neurons, located in soma. Highly expressed in the brain, including the hippocampus, especially in the granular layer of dentate gyrus cells and the pyramidal cell layer of the hippocampus, amygdala, thalamus, hypothalamus, in the layer of Purkinje cells in the cerebellum and the layers of cortex (PubMed:21511949). Particularly strong expression in neurons of the ventromedial hypothalamus, basolateral amygdala, ventral tegmental area, and locus coeruleus (PubMed:21511949). Not detected in glial cells, including astrocytes (PubMed:21511949). In addition to brain, also expressed in the spinal cord (at protein level) (PubMed:21511949). Belongs to the amino acid/polyamine transporter 2 family. amino acid transmembrane transport L-histidine transmembrane transporter activity L-glutamate transmembrane transporter activity ion transport sodium ion transport amino acid transport asparagine transport glutamine transport amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity L-alanine transmembrane transporter activity L-asparagine transmembrane transporter activity L-aspartate transmembrane transporter activity L-glutamine transmembrane transporter activity L-leucine transmembrane transporter activity L-methionine transmembrane transporter activity L-serine transmembrane transporter activity branched-chain amino acid transport neutral amino acid transport L-alanine transport L-glutamate transport methionine transport L-serine transport membrane integral component of membrane axon neuronal cell body L-aspartate transport L-histidine transmembrane transport cation transmembrane transport L-alpha-amino acid transmembrane transport uc009mzg.1 uc009mzg.2 uc009mzg.3 
ENSMUST00000040484.6 Gcsh ENSMUST00000040484.6 glycine cleavage system protein H (aminomethyl carrier), transcript variant 2 (from RefSeq NR_157137.1) ENSMUST00000040484.1 ENSMUST00000040484.2 ENSMUST00000040484.3 ENSMUST00000040484.4 ENSMUST00000040484.5 GCSH_MOUSE Gcsh NR_157137 Q91WK5 Q9CY75 Q9D197 uc009not.1 uc009not.2 uc009not.3 The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST). Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence=; Note=Binds 1 lipoyl cofactor covalently. ; The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH). Interacts with GLDC (By similarity). Mitochondrion Belongs to the GcvH family. aminomethyltransferase activity mitochondrion glycine cleavage complex protein lipoylation glycine decarboxylation via glycine cleavage system enzyme binding methylation uc009not.1 uc009not.2 uc009not.3 
ENSMUST00000040487.4 Rsad1 ENSMUST00000040487.4 radical S-adenosyl methionine domain containing 1 (from RefSeq NM_001013381.2) B2RTE1 ENSMUST00000040487.1 ENSMUST00000040487.2 ENSMUST00000040487.3 NM_001013381 Q5SUV1 Q6PHM8 RSAD1_MOUSE uc007kza.1 uc007kza.2 uc007kza.3 uc007kza.4 May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl- L-methionine (By similarity). Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Mitochondrion Might carry two S-adenosyl-L-methionine binding sites with only one binding to the iron-sulfur cluster. Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily. catalytic activity coproporphyrinogen oxidase activity cytoplasm mitochondrion porphyrin-containing compound biosynthetic process metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding oxidation-reduction process uc007kza.1 uc007kza.2 uc007kza.3 uc007kza.4 
ENSMUST00000040489.9 Trpm6 ENSMUST00000040489.9 transient receptor potential cation channel, subfamily M, member 6, transcript variant 2 (from RefSeq NR_157571.1) ENSMUST00000040489.1 ENSMUST00000040489.2 ENSMUST00000040489.3 ENSMUST00000040489.4 ENSMUST00000040489.5 ENSMUST00000040489.6 ENSMUST00000040489.7 ENSMUST00000040489.8 NR_157571 Q8CIR4 TRPM6_MOUSE uc008gya.1 uc008gya.2 uc008gya.3 uc008gya.4 Essential ion channel and kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Forms heterodimers with TRPM7. Interacts (via kinase domain) with RACK1 (By similarity). Cell membrane ; Multi-pass membrane protein. In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily. nucleotide binding protein serine/threonine kinase activity ion channel activity cation channel activity calcium channel activity ATP binding plasma membrane protein phosphorylation ion transport cation transport calcium ion transport response to toxic substance membrane integral component of membrane kinase activity phosphorylation apical plasma membrane transferase activity metal ion transport brush border membrane metal ion binding protein tetramerization transmembrane transport calcium ion transmembrane transport uc008gya.1 uc008gya.2 uc008gya.3 uc008gya.4 
ENSMUST00000040498.12 Rnf39 ENSMUST00000040498.12 ring finger protein 39 (from RefSeq NM_001099632.1) A2RT81 A2RT81_MOUSE ENSMUST00000040498.1 ENSMUST00000040498.10 ENSMUST00000040498.11 ENSMUST00000040498.2 ENSMUST00000040498.3 ENSMUST00000040498.4 ENSMUST00000040498.5 ENSMUST00000040498.6 ENSMUST00000040498.7 ENSMUST00000040498.8 ENSMUST00000040498.9 NM_001099632 Rnf39 uc008clm.1 uc008clm.2 uc008clm.3 metal ion binding uc008clm.1 uc008clm.2 uc008clm.3 
ENSMUST00000040500.9 Dgkb ENSMUST00000040500.9 diacylglycerol kinase, beta, transcript variant 2 (from RefSeq NM_178681.5) DGKB_MOUSE ENSMUST00000040500.1 ENSMUST00000040500.2 ENSMUST00000040500.3 ENSMUST00000040500.4 ENSMUST00000040500.5 ENSMUST00000040500.6 ENSMUST00000040500.7 ENSMUST00000040500.8 Kiaa0718 NM_178681 Q6NS52 Q80TT5 uc007nkl.1 uc007nkl.2 uc007nkl.3 Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:20657643). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (PubMed:20657643). Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10273; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40339, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77097, ChEBI:CHEBI:77098, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40340; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40324; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328; Evidence=; Reaction=1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43428, ChEBI:CHEBI:15378, ChEBI:CHEBI:18155, ChEBI:CHEBI:30616, ChEBI:CHEBI:78227, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43429; Evidence=; Activated by calcium. Lipid metabolism; glycerolipid metabolism. Postsynaptic cell membrane ; Peripheral membrane protein Cell membrane ; Peripheral membrane protein Cytoplasm Note=Translocation to the plasma membrane is induced by phorbol esters. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NS52-1; Sequence=Displayed; Name=2; IsoId=Q6NS52-2; Sequence=VSP_021900; Expressed in hippocampus, cerebral cortex, and caudate putamen (at protein level). Homozygous knockout mice are viable and fertile with no significant difference in weight (PubMed:20657643). However, long-term potentiation (LTP) and cognitive functions including spatial and long-term memory are affected in these mice (PubMed:20657643). A decrease in the total length of neurites and branches together with a reduced number of neurite spines are observed (PubMed:20657643). Belongs to the eukaryotic diacylglycerol kinase family. nucleotide binding NAD+ kinase activity diacylglycerol kinase activity calcium ion binding ATP binding cytoplasm cytosol plasma membrane signal transduction protein kinase C-activating G-protein coupled receptor signaling pathway response to bacterium membrane kinase activity phosphorylation transferase activity intracellular signal transduction diacylglycerol metabolic process glycerolipid metabolic process lipid phosphorylation metal ion binding modulation of synaptic transmission glutamatergic synapse uc007nkl.1 uc007nkl.2 uc007nkl.3 
ENSMUST00000040504.12 Klhl4 ENSMUST00000040504.12 kelch-like 4, transcript variant 1 (from RefSeq NM_172781.2) B1AZR0 B1AZR0_MOUSE ENSMUST00000040504.1 ENSMUST00000040504.10 ENSMUST00000040504.11 ENSMUST00000040504.2 ENSMUST00000040504.3 ENSMUST00000040504.4 ENSMUST00000040504.5 ENSMUST00000040504.6 ENSMUST00000040504.7 ENSMUST00000040504.8 ENSMUST00000040504.9 Klhl4 NM_172781 uc009udv.1 uc009udv.2 uc009udv.3 uc009udv.4 uc009udv.5 molecular_function cellular_component microtubule organizing center biological_process microtubule cytoskeleton uc009udv.1 uc009udv.2 uc009udv.3 uc009udv.4 uc009udv.5 
ENSMUST00000040506.8 Fam13b ENSMUST00000040506.8 family with sequence similarity 13, member B, transcript variant 1 (from RefSeq NM_146084.2) ENSMUST00000040506.1 ENSMUST00000040506.2 ENSMUST00000040506.3 ENSMUST00000040506.4 ENSMUST00000040506.5 ENSMUST00000040506.6 ENSMUST00000040506.7 FA13B_MOUSE Fam13b1 NM_146084 Q8K2H3 uc008eko.1 uc008eko.2 uc008eko.3 uc008eko.4 Belongs to the FAM13 family. molecular_function GTPase activator activity signal transduction positive regulation of GTPase activity uc008eko.1 uc008eko.2 uc008eko.3 uc008eko.4 
ENSMUST00000040514.8 Irs2 ENSMUST00000040514.8 insulin receptor substrate 2 (from RefSeq NM_001081212.2) B9EJW3 ENSMUST00000040514.1 ENSMUST00000040514.2 ENSMUST00000040514.3 ENSMUST00000040514.4 ENSMUST00000040514.5 ENSMUST00000040514.6 ENSMUST00000040514.7 IRS2_MOUSE NM_001081212 P81122 uc009kuz.1 uc009kuz.2 uc009kuz.3 uc009kuz.4 May mediate the control of various cellular processes by insulin. Interacts with PHIP. P81122; Q923E4: Sirt1; NbExp=2; IntAct=EBI-1369862, EBI-1802585; P81122; P06213-1: INSR; Xeno; NbExp=8; IntAct=EBI-1369862, EBI-15558981; Cytoplasm, cytosol Skeletal muscle, lung, brain, liver, kidney, heart and spleen. positive regulation of mesenchymal cell proliferation negative regulation of B cell apoptotic process insulin receptor binding protein binding cytoplasm cytosol plasma membrane signal transduction brain development positive regulation of cell proliferation insulin receptor signaling pathway response to glucose negative regulation of plasma membrane long-chain fatty acid transport positive regulation of glucose metabolic process protein kinase binding protein phosphatase binding protein domain specific binding positive regulation of cell migration mammary gland development positive regulation of B cell proliferation positive regulation of fatty acid beta-oxidation positive regulation of insulin secretion cellular response to insulin stimulus macromolecular complex negative regulation of kinase activity phosphatidylinositol 3-kinase binding positive regulation of glycogen biosynthetic process positive regulation of glucose import cellular response to glucose stimulus 14-3-3 protein binding cellular response to peptide uc009kuz.1 uc009kuz.2 uc009kuz.3 uc009kuz.4 
ENSMUST00000040518.6 Eif3l ENSMUST00000040518.6 eukaryotic translation initiation factor 3, subunit L (from RefSeq NM_145139.2) EIF3L_MOUSE ENSMUST00000040518.1 ENSMUST00000040518.2 ENSMUST00000040518.3 ENSMUST00000040518.4 ENSMUST00000040518.5 Eif3eip Eif3s6ip NM_145139 Paf67 Q3THF8 Q3TJ04 Q8QZY1 Q91YE4 uc007wsk.1 uc007wsk.2 uc007wsk.3 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3. Cytoplasm Belongs to the eIF-3 subunit L family. fibrillar center formation of cytoplasmic translation initiation complex cytoplasmic translational initiation translation initiation factor activity nucleoplasm nucleolus cytoplasm eukaryotic translation initiation factor 3 complex translation translational initiation eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex viral translational termination-reinitiation uc007wsk.1 uc007wsk.2 uc007wsk.3 
ENSMUST00000040519.12 Coa8 ENSMUST00000040519.12 cytochrome c oxidase assembly factor 8, transcript variant 2 (from RefSeq NM_026511.2) Apop1 Apopt1 COA8_MOUSE ENSMUST00000040519.1 ENSMUST00000040519.10 ENSMUST00000040519.11 ENSMUST00000040519.2 ENSMUST00000040519.3 ENSMUST00000040519.4 ENSMUST00000040519.5 ENSMUST00000040519.6 ENSMUST00000040519.7 ENSMUST00000040519.8 ENSMUST00000040519.9 NM_026511 Q9CQW7 uc007pdu.1 uc007pdu.2 uc007pdu.3 uc007pdu.4 Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Apop-2; IsoId=Q9CQW7-1; Sequence=Displayed; Name=2; Synonyms=Apop-1; IsoId=Q9CQW7-2; Sequence=VSP_041973; Expressed in atherosclerotic smooth muscle cells (at protein level). Expressed in aorta, brain, heart, kidney, liver, lung and spleen. Isoform 1 is strongly expressed in Kidney. Isoform 2 is strongly expressed in brain. In conditions of increased oxidative stress, the protein is stabilized, increasing its mature intramitochondrial form and thereby protecting COX from oxidatively induced degradation. N-terminal mitochondrial targeting sequence is cleaved from the mature protein once in the mitochondrion. In normal conditions, the cytoplasmic precursor protein is rapidly degraded by the ubiquitination-proteasome system (UPS). Oxidative stress induces protein stabilization and import into mitochondria where it protects COX from degradation. Mutant mice generated by CRISPR-Cas9-mediated gene editing are born at the expected Mendelian rate. They show impaired motor skills, with decreased motor coordination and endurance. Mutant show global COX deficiency with reduced enzymatic activity, low steady-state levels of structural subunits and defective assembly in all the tested tissues. Belongs to the COA8 family. First thought to play a role in the regulation of apoptosis, mediating mitochondria-induced cell death in vascular smooth muscle cells through the release of cytochrome c (COX) from mitochondria and the activation of the caspase cascade (PubMed:16782708, PubMed:18977203). However, recent studies show that it is not directly involved in apoptosis regulation but in the protection of COX from oxidatively induced degradation (PubMed:30552096). response to reactive oxygen species molecular_function mitochondrion apoptotic process mitochondrial respiratory chain complex IV assembly positive regulation of smooth muscle cell apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein stabilization positive regulation of release of cytochrome c from mitochondria intrinsic apoptotic signaling pathway matrix side of mitochondrial inner membrane negative regulation of reactive oxygen species biosynthetic process positive regulation of cytochrome-c oxidase activity uc007pdu.1 uc007pdu.2 uc007pdu.3 uc007pdu.4 
ENSMUST00000040523.9 Adamts2 ENSMUST00000040523.9 ADAM metallopeptidase with thrombospondin type 1 motif 2 (from RefSeq NM_175643.3) ATS2_MOUSE ENSMUST00000040523.1 ENSMUST00000040523.2 ENSMUST00000040523.3 ENSMUST00000040523.4 ENSMUST00000040523.5 ENSMUST00000040523.6 ENSMUST00000040523.7 ENSMUST00000040523.8 NM_175643 Q8C9W3 uc007iso.1 uc007iso.2 uc007iso.3 uc007iso.4 This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The encoded protein precursor is proteolytically processed to generate a mature, zinc-dependent enzyme. Mice lacking the encoded protein develop abnormal lungs, fragile skin and male sterility. [provided by RefSeq, Aug 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC046456.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity). Reaction=Cleaves the N-propeptide of collagen chain alpha1(I) at Pro-|- Gln and of alpha1(II) and alpha2(I) at Ala-|-Gln.; EC=3.4.24.14; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; May belong to a multimeric complex. Binds specifically to collagen type XIV (By similarity). Secreted, extracellular space, extracellular matrix The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2- G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3- glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). metalloendopeptidase activity extracellular region extracellular space proteolysis spermatogenesis peptidase activity metallopeptidase activity zinc ion binding protein processing hydrolase activity collagen fibril organization lung development collagen catabolic process extracellular matrix skin development metal ion binding uc007iso.1 uc007iso.2 uc007iso.3 uc007iso.4 
ENSMUST00000040536.6 Batf ENSMUST00000040536.6 basic leucine zipper transcription factor, ATF-like (from RefSeq NM_016767.2) A2RT86 BATF_MOUSE ENSMUST00000040536.1 ENSMUST00000040536.2 ENSMUST00000040536.3 ENSMUST00000040536.4 ENSMUST00000040536.5 NM_016767 O35284 uc007ohd.1 uc007ohd.2 uc007ohd.3 AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class- switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'- TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'- TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs. Heterodimer; mainly heterodimerizes with JUNB. The BATF-JUNB heterodimer interacts with IRF4 and IRF8. Interacts (via bZIP domain) with IRF4 and IRF8; the interaction is direct. Also forms heterodimers with JUN and JUND. Interacts with IFI35. O35284; Q64287: Irf4; NbExp=7; IntAct=EBI-6398523, EBI-6398485; Nucleus. Cytoplasm. Note=Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells. Detected in postnatal and adult lymphoid tissues such as thymus, spleen and lymph nodes. In thymus most concentrated expression is found in the immediate cortical layer. Differentially expressed during T-cell development in thymus. Highly expressed in Th17, Th1 and Th2 cells and in activated B-cells. Up-regulated by STAT3 in response to DNA damage. Induces by IL12 at late effector stage. Down-regulated by STAT5 in follicular T- helper cells (TfH). Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription. Mice are fertile and healthy. They display a normal thymus, spleen and lymph node development, and normal CD4(+) and CD8(+) T-cell development. They also show normal development of natural killer T-cells, B-cells, and conventional and plasmacytoid dendritic cells. They however show defects in T-helper 17 cells (Th17) differentiation and are resistant to experimental autoimmune encephalomyelitis. Loss of follicular T-helper cells (TfH), as well as less production of antibodies with switched isotypes in B-cells is also observed. Belongs to the bZIP family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cytokine production lymphoid progenitor cell differentiation DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus cell differentiation DNA damage response, signal transduction by p53 class mediator defense response to protozoan myeloid dendritic cell differentiation sequence-specific DNA binding T-helper 2 cell differentiation isotype switching positive regulation of transcription from RNA polymerase II promoter hematopoietic stem cell differentiation T-helper 17 cell differentiation T-helper 17 cell lineage commitment uc007ohd.1 uc007ohd.2 uc007ohd.3 
ENSMUST00000040538.10 Sccpdh ENSMUST00000040538.10 saccharopine dehydrogenase (putative), transcript variant 4 (from RefSeq NR_184455.1) ENSMUST00000040538.1 ENSMUST00000040538.2 ENSMUST00000040538.3 ENSMUST00000040538.4 ENSMUST00000040538.5 ENSMUST00000040538.6 ENSMUST00000040538.7 ENSMUST00000040538.8 ENSMUST00000040538.9 NR_184455 Q3TMB9 Q8R127 SCPDL_MOUSE uc007dvp.1 uc007dvp.2 uc007dvp.3 Belongs to the saccharopine dehydrogenase family. molecular_function mitochondrion lipid particle plasma membrane glycolipid biosynthetic process oxidoreductase activity midbody oxidation-reduction process uc007dvp.1 uc007dvp.2 uc007dvp.3 
ENSMUST00000040560.11 Tsfm ENSMUST00000040560.11 Ts translation elongation factor, mitochondrial (from RefSeq NM_025537.3) EFTS_MOUSE ENSMUST00000040560.1 ENSMUST00000040560.10 ENSMUST00000040560.2 ENSMUST00000040560.3 ENSMUST00000040560.4 ENSMUST00000040560.5 ENSMUST00000040560.6 ENSMUST00000040560.7 ENSMUST00000040560.8 ENSMUST00000040560.9 NM_025537 Q3TFF5 Q9CZR8 uc007hhm.1 uc007hhm.2 uc007hhm.3 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Mitochondrion Belongs to the EF-Ts family. translation elongation factor activity nucleus mitochondrion mitochondrial matrix translation translational elongation mitochondrial translational elongation regulation of mitochondrial translation uc007hhm.1 uc007hhm.2 uc007hhm.3 
ENSMUST00000040561.6 Rundc1 ENSMUST00000040561.6 RUN domain containing 1 (from RefSeq NM_172566.4) ENSMUST00000040561.1 ENSMUST00000040561.2 ENSMUST00000040561.3 ENSMUST00000040561.4 ENSMUST00000040561.5 NM_172566 Q0VDN6 Q0VDN7 Q3U072 Q8C3C0 RUND1_MOUSE uc007lov.1 uc007lov.2 uc007lov.3 uc007lov.4 uc007lov.5 May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. in utero embryonic development GTPase activator activity cell intracellular protein transport Rab GTPase binding activation of GTPase activity uc007lov.1 uc007lov.2 uc007lov.3 uc007lov.4 uc007lov.5 
ENSMUST00000040572.10 Zc3h10 ENSMUST00000040572.10 zinc finger CCCH type containing 10 (from RefSeq NM_134003.2) ENSMUST00000040572.1 ENSMUST00000040572.2 ENSMUST00000040572.3 ENSMUST00000040572.4 ENSMUST00000040572.5 ENSMUST00000040572.6 ENSMUST00000040572.7 ENSMUST00000040572.8 ENSMUST00000040572.9 NM_134003 Q8R205 ZC3HA_MOUSE uc007hni.1 uc007hni.2 uc007hni.3 uc007hni.4 Specific regulator of miRNA biogenesis. Binds, via the C3H1- type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA. Nucleus regulation of alternative mRNA splicing, via spliceosome RNA binding nucleus nucleoplasm cytoplasm posttranscriptional regulation of gene expression miRNA binding metal ion binding negative regulation of production of miRNAs involved in gene silencing by miRNA uc007hni.1 uc007hni.2 uc007hni.3 uc007hni.4 
ENSMUST00000040576.10 Parm1 ENSMUST00000040576.10 prostate androgen-regulated mucin-like protein 1 (from RefSeq NM_145562.2) A5JSU4 ENSMUST00000040576.1 ENSMUST00000040576.2 ENSMUST00000040576.3 ENSMUST00000040576.4 ENSMUST00000040576.5 ENSMUST00000040576.6 ENSMUST00000040576.7 ENSMUST00000040576.8 ENSMUST00000040576.9 NM_145562 PARM1_MOUSE Q3TTV0 Q3UFU4 Q923D3 uc008ybw.1 uc008ybw.2 uc008ybw.3 uc008ybw.4 May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. Cell membrane ; Single-pass type I membrane protein Golgi apparatus membrane ; Single-pass type I membrane protein Endosome membrane ; Single-pass type I membrane protein Highly N-glycosylated and O-glycosylated. Belongs to the PARM family. Golgi membrane molecular_function nucleus endosome early endosome late endosome Golgi apparatus cytosol plasma membrane endosome membrane membrane integral component of membrane intracellular membrane-bounded organelle positive regulation of telomerase activity uc008ybw.1 uc008ybw.2 uc008ybw.3 uc008ybw.4 
ENSMUST00000040577.5 Mrm3 ENSMUST00000040577.5 mitochondrial rRNA methyltransferase 3 (from RefSeq NM_183263.5) A4FUR4 ENSMUST00000040577.1 ENSMUST00000040577.2 ENSMUST00000040577.3 ENSMUST00000040577.4 MRM3_MOUSE Mrm3 NM_183263 Q3UGQ7 Q5ND52 Q5U5W2 Q8C1J9 Rnmtl1 uc007kfn.1 uc007kfn.2 uc007kfn.3 uc007kfn.4 S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Reaction=guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine = 2'-O- methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:47756, Rhea:RHEA-COMP:11899, Rhea:RHEA-COMP:11900, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74445; Evidence=; Mitochondrion Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. Sequence=AAH38288.1; Type=Erroneous initiation; Evidence=; Sequence=AAH90975.2; Type=Erroneous initiation; Evidence=; Sequence=AAI15623.1; Type=Erroneous initiation; Evidence=; Sequence=AAI15624.1; Type=Erroneous initiation; Evidence=; Sequence=BAC25446.1; Type=Frameshift; Evidence=; rRNA 2'-O-methylation RNA methylation RNA binding mitochondrion rRNA processing RNA processing methyltransferase activity RNA methyltransferase activity transferase activity methylation rRNA (guanosine-2'-O-)-methyltransferase activity uc007kfn.1 uc007kfn.2 uc007kfn.3 uc007kfn.4 
ENSMUST00000040580.7 Syde1 ENSMUST00000040580.7 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) (from RefSeq NM_027875.1) ENSMUST00000040580.1 ENSMUST00000040580.2 ENSMUST00000040580.3 ENSMUST00000040580.4 ENSMUST00000040580.5 ENSMUST00000040580.6 G3X960 G3X960_MOUSE NM_027875 Syde1 uc007fyb.1 uc007fyb.2 uc007fyb.3 signal transduction regulation of cytoskeleton organization positive regulation of trophoblast cell migration uc007fyb.1 uc007fyb.2 uc007fyb.3 
ENSMUST00000040583.7 Heatr5a ENSMUST00000040583.7 HEAT repeat containing 5A (from RefSeq NM_177171.4) E9QPI0 ENSMUST00000040583.1 ENSMUST00000040583.2 ENSMUST00000040583.3 ENSMUST00000040583.4 ENSMUST00000040583.5 ENSMUST00000040583.6 HTR5A_MOUSE Kiaa1316 NM_177171 Q3TT84 Q3V311 Q5PRF0 Q6P4S9 Q80TF2 Q8C8F7 uc007nnb.1 uc007nnb.2 uc007nnb.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5PRF0-1; Sequence=Displayed; Name=2; IsoId=Q5PRF0-2; Sequence=VSP_029687; Belongs to the HEATR5 family. Sequence=BAC32998.1; Type=Frameshift; Evidence=; Sequence=BAE43352.1; Type=Frameshift; Evidence=; molecular_function cytosol endocytosis protein localization endocytic vesicle retrograde transport, endosome to Golgi uc007nnb.1 uc007nnb.2 uc007nnb.3 
ENSMUST00000040592.6 Crygs ENSMUST00000040592.6 crystallin, gamma S (from RefSeq NM_009967.2) Crygs ENSMUST00000040592.1 ENSMUST00000040592.2 ENSMUST00000040592.3 ENSMUST00000040592.4 ENSMUST00000040592.5 NM_009967 Q3UPY3 Q3UPY3_MOUSE uc007ysj.1 uc007ysj.2 uc007ysj.3 uc007ysj.4 Crystallins are the dominant structural components of the vertebrate eye lens. Belongs to the beta/gamma-crystallin family. uc007ysj.1 uc007ysj.2 uc007ysj.3 uc007ysj.4 
ENSMUST00000040603.14 Agl ENSMUST00000040603.14 amylo-1,6-glucosidase, 4-alpha-glucanotransferase, transcript variant 1 (from RefSeq NM_001081326.1) Agl ENSMUST00000040603.1 ENSMUST00000040603.10 ENSMUST00000040603.11 ENSMUST00000040603.12 ENSMUST00000040603.13 ENSMUST00000040603.2 ENSMUST00000040603.3 ENSMUST00000040603.4 ENSMUST00000040603.5 ENSMUST00000040603.6 ENSMUST00000040603.7 ENSMUST00000040603.8 ENSMUST00000040603.9 F8VPN4 F8VPN4_MOUSE NM_001081326 uc008rcq.1 uc008rcq.2 Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. Reaction=Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.; EC=3.2.1.33; Evidence=; Reaction=Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D- glucan.; EC=2.4.1.25; Evidence=; Cytoplasm Belongs to the glycogen debranching enzyme family. catalytic activity glycogen debranching enzyme activity 4-alpha-glucanotransferase activity amylo-alpha-1,6-glucosidase activity protein binding nucleus cytoplasm glycogen metabolic process glycogen biosynthetic process glycogen catabolic process response to nutrient response to hormone inclusion body sarcoplasmic reticulum carbohydrate binding polysaccharide binding polyubiquitin binding response to glucocorticoid uc008rcq.1 uc008rcq.2 
ENSMUST00000040607.6 Lsm3 ENSMUST00000040607.6 Plays a role in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (from UniProt P62311) AK003125 ENSMUST00000040607.1 ENSMUST00000040607.2 ENSMUST00000040607.3 ENSMUST00000040607.4 ENSMUST00000040607.5 LSM3_MOUSE P62311 Q9Y4Z1 uc009cye.1 uc009cye.2 uc009cye.3 Plays a role in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Nucleus Belongs to the snRNP Sm proteins family. mRNA splicing, via spliceosome P-body nuclear-transcribed mRNA catabolic process RNA binding nucleus spliceosomal complex U6 snRNP mRNA processing RNA splicing U6 snRNA 3'-end binding cytoplasmic mRNA processing body assembly U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome catalytic step 2 spliceosome Lsm1-7-Pat1 complex uc009cye.1 uc009cye.2 uc009cye.3 
ENSMUST00000040609.9 Stpg4 ENSMUST00000040609.9 sperm tail PG rich repeat containing 4 (from RefSeq NM_029298.1) ENSMUST00000040609.1 ENSMUST00000040609.2 ENSMUST00000040609.3 ENSMUST00000040609.4 ENSMUST00000040609.5 ENSMUST00000040609.6 ENSMUST00000040609.7 ENSMUST00000040609.8 NM_029298 Q9DAG5 STPG4_MOUSE Stpg4 uc008duw.1 uc008duw.2 uc008duw.3 Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote (PubMed:23560077, PubMed:28930672). Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) (PubMed:23560077, PubMed:28930672). Interacts with histone H3 (PubMed:23560077). Interacts with histone H4 (PubMed:23560077). Interacts with METTL23 (PubMed:28930672). Cytoplasm Nucleus Note=Localizes in female and male zygote pronucleus (PubMed:23560077, PubMed:16571911). Associates preferentially with the paternal chromatin during zygote development (PubMed:23560077). Expressed in ovary and testis (PubMed:16571911). Expressed in spermatocytes I in the pachytene stage, round spermatids, and elongated spermatids (PubMed:16571911). Expressed in the germinal vesicle (GV) stage and stage 2 meiosis (MII) oocytes and pre- implantation embryos until blastocyst stage (at protein level) (PubMed:16571911, PubMed:23560077). No visible phenotype (PubMed:28930672). Mice were born at the expected Mendelian ratio and show no overt phenotype (PubMed:28930672). Zygotes however display strongly reduced levels of 5-hydroxymethylcytosine (5hmC) (PubMed:28930672). female pronucleus male pronucleus chromatin binding nucleus cytoplasm chromatin organization multicellular organism development histone binding germinal vesicle DNA demethylation of male pronucleus C-5 methylation of cytosine positive regulation of DNA demethylation uc008duw.1 uc008duw.2 uc008duw.3 
ENSMUST00000040616.9 Kctd7 ENSMUST00000040616.9 potassium channel tetramerisation domain containing 7 (from RefSeq NM_172509.4) B2RSZ3 ENSMUST00000040616.1 ENSMUST00000040616.2 ENSMUST00000040616.3 ENSMUST00000040616.4 ENSMUST00000040616.5 ENSMUST00000040616.6 ENSMUST00000040616.7 ENSMUST00000040616.8 KCTD7_MOUSE NM_172509 Q3USA6 Q80WW8 Q8BJK1 Q8C0S7 uc008zue.1 uc008zue.2 uc008zue.3 May be involved in the control of excitability of cortical neurons. Interacts with CUL3. Cell membrane Cytoplasm, cytosol High expression in brain, particularly in post- mitotic neurons. Expressed in the mitral cells of the olfactory bulbs, the hippocampus, the deep layers of the cerebral cortex and Purkinje cells of the cerebellum. Not detected in astrocytes or microglial cells. Also expressed in heart, liver, spleen and kidney. Sequence=BAC26691.1; Type=Frameshift; Evidence=; molecular_function cytoplasm cytosol plasma membrane membrane cellular potassium ion homeostasis positive regulation of transporter activity protein homooligomerization membrane hyperpolarization glutamate homeostasis uc008zue.1 uc008zue.2 uc008zue.3 
ENSMUST00000040622.3 P2ry13 ENSMUST00000040622.3 purinergic receptor P2Y, G-protein coupled 13 (from RefSeq NM_028808.3) ENSMUST00000040622.1 ENSMUST00000040622.2 Gpr86 NM_028808 P2Y13_MOUSE Q0VF10 Q8C412 Q8CAL2 Q9D8I2 uc008piq.1 uc008piq.2 uc008piq.3 uc008piq.4 uc008piq.5 Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity endoplasmic reticulum plasma membrane signal transduction G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity membrane integral component of membrane G-protein coupled purinergic nucleotide receptor signaling pathway G-protein coupled purinergic nucleotide receptor activity cellular response to organic cyclic compound uc008piq.1 uc008piq.2 uc008piq.3 uc008piq.4 uc008piq.5 
ENSMUST00000040624.7 Bicral ENSMUST00000040624.7 Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP- dependent manner. (from UniProt Q8CHH5) AB093219 BICRL_MOUSE Bicral ENSMUST00000040624.1 ENSMUST00000040624.2 ENSMUST00000040624.3 ENSMUST00000040624.4 ENSMUST00000040624.5 ENSMUST00000040624.6 Gltscr1l Kiaa0240 Q8CHH5 uc012aur.1 uc012aur.2 uc012aur.3 Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP- dependent manner. Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A. Sequence=AK029927; Type=Frameshift; Evidence=; molecular_function biological_process SWI/SNF complex uc012aur.1 uc012aur.2 uc012aur.3 
ENSMUST00000040636.9 Sec1 ENSMUST00000040636.9 secretory blood group 1, transcript variant 1 (from RefSeq NM_001405895.1) ENSMUST00000040636.1 ENSMUST00000040636.2 ENSMUST00000040636.3 ENSMUST00000040636.4 ENSMUST00000040636.5 ENSMUST00000040636.6 ENSMUST00000040636.7 ENSMUST00000040636.8 NM_001405895 Q8CDC9 Q8CDC9_MOUSE Sec1 uc009gwo.1 uc009gwo.2 uc009gwo.3 Reaction=a ganglioside GM1 + GDP-beta-L-fucose = a ganglioside Fuc-GM1 + GDP + H(+); Xref=Rhea:RHEA:48292, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:82639, ChEBI:CHEBI:90189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48293; Evidence=; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 11 family. Golgi apparatus carbohydrate metabolic process protein glycosylation galactoside 2-alpha-L-fucosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups Golgi cisterna membrane fucosylation uc009gwo.1 uc009gwo.2 uc009gwo.3 
ENSMUST00000040647.11 Fgf1 ENSMUST00000040647.11 fibroblast growth factor 1 (from RefSeq NM_010197.3) ENSMUST00000040647.1 ENSMUST00000040647.10 ENSMUST00000040647.2 ENSMUST00000040647.3 ENSMUST00000040647.4 ENSMUST00000040647.5 ENSMUST00000040647.6 ENSMUST00000040647.7 ENSMUST00000040647.8 ENSMUST00000040647.9 Fgf1 Fgf2b NM_010197 Q6ZWS1 Q6ZWS1_MOUSE uc008eso.1 uc008eso.2 uc008eso.3 Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling. Cytoplasm, cell cortex Secreted Cytoplasm Cytoplasm, cytosol Nucleus Belongs to the heparin-binding growth factors family. activation of MAPK activity angiogenesis fibroblast growth factor receptor binding integrin binding extracellular region extracellular space nucleus nucleolus cytoplasm cytosol cell cortex multicellular organism development growth factor activity heparin binding cell proliferation positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway positive regulation of endothelial cell migration cell differentiation positive regulation of cell migration Hsp70 protein binding activation of protein kinase B activity cellular response to heat positive regulation of MAP kinase activity S100 protein binding positive regulation of cholesterol biosynthetic process positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter positive regulation of cell division branch elongation involved in ureteric bud branching mesonephric epithelium development regulation of endothelial tube morphogenesis positive regulation of intracellular signal transduction positive regulation of sprouting angiogenesis regulation of endothelial cell chemotaxis to fibroblast growth factor uc008eso.1 uc008eso.2 uc008eso.3 
ENSMUST00000040655.14 H2-Aa ENSMUST00000040655.14 histocompatibility 2, class II antigen A, alpha (from RefSeq NM_010378.3) ENSMUST00000040655.1 ENSMUST00000040655.10 ENSMUST00000040655.11 ENSMUST00000040655.12 ENSMUST00000040655.13 ENSMUST00000040655.2 ENSMUST00000040655.3 ENSMUST00000040655.4 ENSMUST00000040655.5 ENSMUST00000040655.6 ENSMUST00000040655.7 ENSMUST00000040655.8 ENSMUST00000040655.9 HA2B_MOUSE NM_010378 O78195 P14434 uc008ccd.1 uc008ccd.2 uc008ccd.3 uc008ccd.4 Membrane ; Single-pass type I membrane protein Belongs to the MHC class II family. adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II protein binding lysosome plasma membrane immune response external side of plasma membrane membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II response to interferon-gamma negative regulation of T cell proliferation peptide antigen binding MHC class II protein complex positive regulation of T cell differentiation protein heterodimerization activity antigen processing and presentation of peptide antigen uc008ccd.1 uc008ccd.2 uc008ccd.3 uc008ccd.4 
ENSMUST00000040656.8 Bphl ENSMUST00000040656.8 biphenyl hydrolase like, transcript variant 1 (from RefSeq NM_026512.2) BPHL_MOUSE ENSMUST00000040656.1 ENSMUST00000040656.2 ENSMUST00000040656.3 ENSMUST00000040656.4 ENSMUST00000040656.5 ENSMUST00000040656.6 ENSMUST00000040656.7 NM_026512 Q8BVH2 Q8R164 Q8R589 Q9DCC6 uc007qba.1 uc007qba.2 uc007qba.3 Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol (By similarity). Monomer. May also form homodimers (By similarity). Cytoplasm Belongs to the AB hydrolase superfamily. Lipase family. Sequence=BAC37185.1; Type=Erroneous initiation; Evidence=; cytoplasm mitochondrion hydrolase activity uc007qba.1 uc007qba.2 uc007qba.3 
ENSMUST00000040667.13 Zfp300 ENSMUST00000040667.13 zinc finger protein 300, transcript variant 2 (from RefSeq NM_183185.3) A2AE21 A2AE21_MOUSE ENSMUST00000040667.1 ENSMUST00000040667.10 ENSMUST00000040667.11 ENSMUST00000040667.12 ENSMUST00000040667.2 ENSMUST00000040667.3 ENSMUST00000040667.4 ENSMUST00000040667.5 ENSMUST00000040667.6 ENSMUST00000040667.7 ENSMUST00000040667.8 ENSMUST00000040667.9 NM_183185 Zfp300 uc009sum.1 uc009sum.2 uc009sum.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc009sum.1 uc009sum.2 uc009sum.3 
ENSMUST00000040668.9 Osbpl2 ENSMUST00000040668.9 oxysterol binding protein-like 2 (from RefSeq NM_144500.4) ENSMUST00000040668.1 ENSMUST00000040668.2 ENSMUST00000040668.3 ENSMUST00000040668.4 ENSMUST00000040668.5 ENSMUST00000040668.6 ENSMUST00000040668.7 ENSMUST00000040668.8 NM_144500 OSBL2_MOUSE Q3TCK8 Q8BX94 Q8R0H8 uc008oil.1 uc008oil.2 uc008oil.3 Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5- bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro). Monomer. Homotetramer; phosphatidylinositol-4,5-bisphosphate binding promotes formation of stable tetramers. Interacts with DIAPH1. Cytoplasm, cytosol Lipid droplet Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Detected on the surface of cytosolic lipid droplets. Recruited to the cell membrane by phosphatidylinositol-phosphate binding. Detected in cochlea, in inner and outer hair cells in the organ of Corti (at protein level). Belongs to the OSBP family. phosphatidylinositol-4,5-bisphosphate binding cytoplasm lipid particle cytosol plasma membrane lipid transport plasma membrane organization lipid binding phosphatidylinositol transporter activity cholesterol binding phospholipid transport membrane cholesterol transport extrinsic component of cytoplasmic side of plasma membrane intracellular cholesterol transport sterol binding intracellular membrane-bounded organelle protein homotetramerization uc008oil.1 uc008oil.2 uc008oil.3 
ENSMUST00000040676.11 Ankrd54 ENSMUST00000040676.11 ankyrin repeat domain 54, transcript variant 1 (from RefSeq NM_144849.1) ANR54_MOUSE ENSMUST00000040676.1 ENSMUST00000040676.10 ENSMUST00000040676.2 ENSMUST00000040676.3 ENSMUST00000040676.4 ENSMUST00000040676.5 ENSMUST00000040676.6 ENSMUST00000040676.7 ENSMUST00000040676.8 ENSMUST00000040676.9 Liar NM_144849 Q3UPC5 Q3UZL7 Q91WK7 uc007wsi.1 uc007wsi.2 uc007wsi.3 Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation. Interacts (via ankyrin repeat region) with LYN (via SH3- domain) in an activation-independent status of LYN. Forms a multiprotein complex with LYN and HCLS1. Interacts with TSN2, VAV1, DBNL and LASP1. Nucleus Cytoplasm Midbody Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation. Expressed in a variety of hemopoietic cell lines and tissue with high levels in testis. Highly expressed in ciliated cells. Expressed in brachial arches, maxillary process, fore and hind limb buds and in the developing gastrointestinal tract of day 10 embryos. Sequence=BAE25471.1; Type=Frameshift; Evidence=; protein binding nucleus cytoplasm nucleocytoplasmic transport protein kinase regulator activity midbody macromolecular complex binding positive regulation of erythrocyte differentiation regulation of protein kinase activity regulation of intracellular signal transduction uc007wsi.1 uc007wsi.2 uc007wsi.3 
ENSMUST00000040677.6 Eepd1 ENSMUST00000040677.6 endonuclease/exonuclease/phosphatase family domain containing 1 (from RefSeq NM_026189.3) EEPD1_MOUSE ENSMUST00000040677.1 ENSMUST00000040677.2 ENSMUST00000040677.3 ENSMUST00000040677.4 ENSMUST00000040677.5 Kiaa1706 NM_026189 Q3TGW2 Q69ZC7 Q8K3B5 Q9D7J3 uc009opn.1 uc009opn.2 uc009opn.3 Sequence=BAD32517.1; Type=Erroneous initiation; Evidence=; DNA binding cellular_component DNA repair biological_process uc009opn.1 uc009opn.2 uc009opn.3 
ENSMUST00000040687.12 Tax1bp3 ENSMUST00000040687.12 Tax1 (human T cell leukemia virus type I) binding protein 3 (from RefSeq NM_029564.2) ENSMUST00000040687.1 ENSMUST00000040687.10 ENSMUST00000040687.11 ENSMUST00000040687.2 ENSMUST00000040687.3 ENSMUST00000040687.4 ENSMUST00000040687.5 ENSMUST00000040687.6 ENSMUST00000040687.7 ENSMUST00000040687.8 ENSMUST00000040687.9 NM_029564 Q9DBG9 TX1B3_MOUSE Tax1bp3 uc007kac.1 uc007kac.2 uc007kac.3 May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway (By similarity). Interacts (via its PDZ domain) with GLS2. Interacts (via its PDZ domain) with RTKN (via the C-terminal region); this interaction facilitates Rho-mediated activation of the FOS serum response element (SRE). Interacts (via PDZ domain) with ARHGEF16. Interacts (via PDZ domain) with KCNJ4 (via C-terminus). Competes with LIN7A for KCNJ4 binding (By similarity). Interacts (via its PDZ domain) with CTNNB1; this interaction inhibits the transcriptional activity of CTNNB1. Interacts with ADGRB2 (By similarity). Q9DBG9; Q02248: Ctnnb1; NbExp=6; IntAct=EBI-1161647, EBI-397872; Q9DBG9; P35222: CTNNB1; Xeno; NbExp=3; IntAct=EBI-1161647, EBI-491549; Cytoplasm Nucleus Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Recruited to the cell membrane by interaction with membrane proteins. fibrillar center protein binding nucleus cytoplasm plasma membrane Rho protein signal transduction beta-catenin binding protein C-terminus binding negative regulation of cell proliferation actin cytoskeleton membrane Wnt signaling pathway negative regulation of Wnt signaling pathway intracellular membrane-bounded organelle activation of GTPase activity negative regulation of protein localization to cell surface uc007kac.1 uc007kac.2 uc007kac.3 
ENSMUST00000040695.5 Sbspon ENSMUST00000040695.5 somatomedin B and thrombospondin, type 1 domain containing (from RefSeq NM_001033288.3) B2RVH7 ENSMUST00000040695.1 ENSMUST00000040695.2 ENSMUST00000040695.3 ENSMUST00000040695.4 Gm106 NM_001033288 Q3UPR9 Rpesp SBSPO_MOUSE uc007ajj.1 uc007ajj.2 Secreted, extracellular space, extracellular matrix Belongs to the thrombospondin family. molecular_function scavenger receptor activity extracellular region endocytosis immune response biological_process polysaccharide binding uc007ajj.1 uc007ajj.2 
ENSMUST00000040706.9 Cnst ENSMUST00000040706.9 consortin, connexin sorting protein (from RefSeq NM_146105.3) CNST_MOUSE ENSMUST00000040706.1 ENSMUST00000040706.2 ENSMUST00000040706.3 ENSMUST00000040706.4 ENSMUST00000040706.5 ENSMUST00000040706.6 ENSMUST00000040706.7 ENSMUST00000040706.8 NM_146105 Q8BFS5 Q8CBC4 Q8K053 uc007dvo.1 uc007dvo.2 uc007dvo.3 Required for targeting of connexins to the plasma membrane. Interacts with connexins GJA1/CX43, GJB1/CX32, GJB2/CX26, GJB3/CX31, GJB6/CX30 and GJC1/CX45. Also interacts with GGA1 and GGA2. Does not interact with PANX1. Q8CBC4-3; Q8R0H9: Gga1; NbExp=2; IntAct=EBI-2615407, EBI-2616212; Q8CBC4-3; Q6P5E6: Gga2; NbExp=2; IntAct=EBI-2615407, EBI-2616239; Q8CBC4-3; P21994: Gjb2; Xeno; NbExp=2; IntAct=EBI-2615407, EBI-2616119; Cell membrane ; Single-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle Note=Located predominantly in the trans-Golgi network. Probably trafficks between the trans-Golgi network and the cell membrane via the secretory pathway (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CBC4-1; Sequence=Displayed; Name=2; IsoId=Q8CBC4-2; Sequence=VSP_025821, VSP_025822; Name=3; IsoId=Q8CBC4-3; Sequence=VSP_038657; Belongs to the CNST family. protein binding Golgi apparatus trans-Golgi network plasma membrane negative regulation of phosphatase activity membrane integral component of membrane phosphatase binding transport vesicle cytoplasmic vesicle macromolecular complex positive regulation of Golgi to plasma membrane protein transport intracellular membrane-bounded organelle connexin binding uc007dvo.1 uc007dvo.2 uc007dvo.3 
ENSMUST00000040715.8 Mustn1 ENSMUST00000040715.8 musculoskeletal, embryonic nuclear protein 1 (from RefSeq NM_181390.3) ENSMUST00000040715.1 ENSMUST00000040715.2 ENSMUST00000040715.3 ENSMUST00000040715.4 ENSMUST00000040715.5 ENSMUST00000040715.6 ENSMUST00000040715.7 MSTN1_MOUSE NM_181390 Q99JI1 uc007svu.1 uc007svu.2 uc007svu.3 uc007svu.4 May be involved in the development and regeneration of the musculoskeletal system. Nucleus Belongs to the MUSTANG family. chondrocyte differentiation molecular_function nucleus nucleoplasm positive regulation of gene expression embryonic limb morphogenesis positive regulation of chondrocyte differentiation chondrocyte proliferation wound healing tissue regeneration positive regulation of proteoglycan biosynthetic process positive regulation of chondrocyte proliferation uc007svu.1 uc007svu.2 uc007svu.3 uc007svu.4 
ENSMUST00000040717.7 Kif15 ENSMUST00000040717.7 kinesin family member 15 (from RefSeq NM_010620.1) ENSMUST00000040717.1 ENSMUST00000040717.2 ENSMUST00000040717.3 ENSMUST00000040717.4 ENSMUST00000040717.5 ENSMUST00000040717.6 KIF15_MOUSE Klp2 Knsl7 NM_010620 O35065 Q6P9L6 Q70MX5 uc009sfl.1 uc009sfl.2 uc009sfl.3 Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. Interacts with MKI67 and TPX2. Cytoplasm Cytoplasm, cytoskeleton, spindle Note=Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Localizes at the spindle poles and microtubules prior to anaphase. Localizes at the central spindle at anaphase. Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells. Colocalizes with actin in interphase. Colocalizes in dendrites and in growth cone of axons with microtubules. Colocalizes with TPX2 in mitosis (By similarity). Expressed in brain (neurons in the external germinal layer of the cerebellum and in ventricular zones) (at protein level). Expressed in spleen and testis. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily. nucleotide binding microtubule motor activity ATP binding cytoplasm spindle cytoskeleton kinesin complex microtubule microtubule-based movement microtubule binding ATPase activity uc009sfl.1 uc009sfl.2 uc009sfl.3 
ENSMUST00000040718.6 Ostm1 ENSMUST00000040718.6 osteopetrosis associated transmembrane protein 1 (from RefSeq NM_172416.3) ENSMUST00000040718.1 ENSMUST00000040718.2 ENSMUST00000040718.3 ENSMUST00000040718.4 ENSMUST00000040718.5 Gl NM_172416 OSTM1_MOUSE Q8BGT0 uc007eyv.1 uc007eyv.2 uc007eyv.3 uc007eyv.4 Required for osteoclast and melanocyte maturation and function. Chloride channel 7 are heteromers of alpha (CLCN7) and beta (OSTM1) subunits. Q8BGT0; O70496: Clcn7; NbExp=7; IntAct=EBI-987431, EBI-987482; Lysosome membrane ingle-pass type I membrane protein Note=Requires CLCN7 to travel to lysosomes. Expressed primarily in osteoclasts and melanocytes as well as brain, kidney and spleen. Found at lower levels in the thymus, testis, heart and liver. Expression was detected in fetal liver neuronal and bone tissues (12.5 dpc and 15.5 dpc). High expression was detected in thymus and gut at 18.5 dpc and continued postnatally. Expression in bone (mandible and vertebrae) and brain tissues (cerebellum, hippocampus and cortex) remained high after birth. In addition high expression was detected in kidney, spleen and skin at P5 and P10. Undergoes proteolytic cleavage in the luminal domain, the cleaved fragments might be linked by disulfide bonds with the remnant of the protein. Highly N-glycosylated. Note=Defects in Ostm1 are the cause of the spontaneous gray- lethal (gl) mutant, which is responsible for a coat color defect and for the development of the most severe autosomal recessive form of osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Belongs to the OSTM1 family. protein binding lysosome lysosomal membrane cytosol membrane integral component of membrane osteoclast differentiation uc007eyv.1 uc007eyv.2 uc007eyv.3 uc007eyv.4 
ENSMUST00000040729.9 Clcn7 ENSMUST00000040729.9 chloride channel, voltage-sensitive 7, transcript variant 1 (from RefSeq NM_011930.4) Clcn7 ENSMUST00000040729.1 ENSMUST00000040729.2 ENSMUST00000040729.3 ENSMUST00000040729.4 ENSMUST00000040729.5 ENSMUST00000040729.6 ENSMUST00000040729.7 ENSMUST00000040729.8 NM_011930 Q6RUT9 Q6RUT9_MOUSE uc008azv.1 uc008azv.2 uc008azv.3 uc008azv.4 Membrane ulti-pass membrane protein Belongs to the chloride channel (TC 2.A.49) family. voltage-gated chloride channel activity nucleoplasm ion transport chloride transport response to pH membrane integral component of membrane cytoplasmic vesicle transmembrane transport chloride transmembrane transport uc008azv.1 uc008azv.2 uc008azv.3 uc008azv.4 
ENSMUST00000040735.12 Amdhd2 ENSMUST00000040735.12 amidohydrolase domain containing 2 (from RefSeq NM_172935.4) ENSMUST00000040735.1 ENSMUST00000040735.10 ENSMUST00000040735.11 ENSMUST00000040735.2 ENSMUST00000040735.3 ENSMUST00000040735.4 ENSMUST00000040735.5 ENSMUST00000040735.6 ENSMUST00000040735.7 ENSMUST00000040735.8 ENSMUST00000040735.9 NAGA_MOUSE NM_172935 Q8BK10 Q8JZV7 uc008aum.1 uc008aum.2 uc008aum.3 Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Reaction=H2O + N-acetyl-D-glucosamine 6-phosphate = acetate + D- glucosamine 6-phosphate; Xref=Rhea:RHEA:22936, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:57513, ChEBI:CHEBI:58725; EC=3.5.1.25; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 1 divalent metal cation per subunit. ; Amino-sugar metabolism; N-acetylneuraminate degradation. Belongs to the metallo-dependent hydrolases superfamily. NagA family. carbohydrate metabolic process N-acetylglucosamine metabolic process N-acetylglucosamine catabolic process N-acetylglucosamine-6-phosphate deacetylase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds N-acetylneuraminate catabolic process metal ion binding N-acetylgalactosamine-6-phosphate deacetylase activity uc008aum.1 uc008aum.2 uc008aum.3 
ENSMUST00000040746.8 Dynlt2a1 ENSMUST00000040746.8 dynein light chain Tctex-type 2A1, transcript variant 1 (from RefSeq NM_011560.3) A0A0R4J284 A0A0R4J284_MOUSE Dynlt2a1 Dynlt2a2 ENSMUST00000040746.1 ENSMUST00000040746.2 ENSMUST00000040746.3 ENSMUST00000040746.4 ENSMUST00000040746.5 ENSMUST00000040746.6 ENSMUST00000040746.7 NM_011560 uc008anz.1 uc008anz.2 uc008anz.3 uc008anz.4 uc008anz.5 This gene is one of three genes with a very high degree of similarity to each other within a 77 kb genomic span on Chromosome 17 A2. This gene is the most distal copy of the three genes. [provided by RefSeq, Jul 2008]. Belongs to the dynein light chain Tctex-type family. molecular_function cellular_component biological_process uc008anz.1 uc008anz.2 uc008anz.3 uc008anz.4 uc008anz.5 
ENSMUST00000040766.9 Tmed10 ENSMUST00000040766.9 transmembrane p24 trafficking protein 10 (from RefSeq NM_026775.4) ENSMUST00000040766.1 ENSMUST00000040766.2 ENSMUST00000040766.3 ENSMUST00000040766.4 ENSMUST00000040766.5 ENSMUST00000040766.6 ENSMUST00000040766.7 ENSMUST00000040766.8 NM_026775 Q3U7I7 Q6P227 Q922U8 Q9D1D4 TMEDA_MOUSE Tmed10 Tmp21 uc007ogz.1 uc007ogz.2 uc007ogz.3 Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi. The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes. Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side. Mainly functions in the early secretory pathway and cycles between the ER, ER- Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles. In COPII vesicle- mediated anterograde transport, involved in the transport of GPI- anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER (By similarity). Recognizes GPI anchors structural remodeled in the ER by the GPI inositol-deacylase/PGAP1 and the metallophosphoesterase MPPE1/PGAP5 (By similarity). In COPI vesicle-mediated retrograde transport, involved in the biogenesis of COPI vesicles and vesicle coat recruitment. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent from the modulation of gamma- secretase activity) (By similarity). Involved in the KDELR2-mediated retrograde transport of the toxin A subunit (CTX-A-K63)together with COPI and the COOH terminus of KDELR2 (By similarity). On Golgi membranes, acts as a primary receptor for ARF1-GDP, a GTP-binding protein involved in COPI-vesicle formation. Increases coatomer- dependent GTPase-activating activity of ARFGAP2 which mediates the hydrolysis of ARF1-bound GTP and therefore modulates protein trafficking from the Golgi apparatus. Involved in the exocytic trafficking of G protein-coupled receptors F2LR1/PAR2 (trypsin and tryspin-like enzyme receptor), OPRM1 (opioid receptor) and P2RY4 (UTD and UDP receptor) from the Golgi to the plasma membrane, thus contributing to receptor resensitization. In addition to its cargo receptor activity, may also act as a protein channel after oligomerization, facilitating the post-translational entry of leaderless cytoplasmic cargo into the ERGIC. Involved in the translocation into ERGIC, the vesicle entry and the secretion of leaderless cargos (lacking the secretion signal sequence), including the mature form of interleukin 1/IL-1 family members, the alpha- crystallin B chain HSPB5, the carbohydrate-binding proteins galectin- 1/LGALS1 and galectin-3/LGALS3, the microtubule-associated protein Tau/MAPT, and the annexin A1/ANXA1; the translocation process is dependent on cargo protein unfolding and enhanced by chaperones HSP90AB1 and HSP90B1/GRP9. Could also associates with the presenilin- dependent gamma-secretase complex in order to regulate gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40/Abeta40 (By similarity). Predominantly dimeric and to a lesser extent monomeric in the ER. Monomer and dimer in ERGIC and cis-Golgi network. Forms homooligomer (via GOLD domain); the assembly is promoted by direct binding with leaderless cargos and may form a protein channel that facilitates cargo entry into the ERGIC. Forms heterooligomeric complexes with other members of the p24 family such as TMED2, TMED7 and TMED9. Interacts (via GOLD domain) with TMED2 (via GOLD domain); the complex is required for export of TMED10 from the ER to the cis-Golgi network; the complex is proposed to be involved in cis-Golgi network dynamics and / or biogenesis. Associates with the COPI vesicle coat subunits (coatomer) (By similarity). Tetramerization of the cytoplasmic domain at the Golgi membrane in vitro; the complex is proposed to interact with COPI coatomer and induce budding of the vesicles (By similarity). Interacts with COPG1; the interaction involves TMED10 homodimer. Interacts with ARF1 (GDP-bound); the interaction probably involves a TMED10 oligomer. Interacts with SEC23A, SEC24B, SEC24C and SEC24D components of the coat protein complex II/COPII, indicative of an association of TMED10 with the COPII vesicle coat. Interacts with CD59. Interacts with MPPE1/PGAP5; the complex might recruit and sort GPI-anchored proteins to the ER-exit site, or the interaction might lead to recycling of PGAP5 between the ER and the Golgi. Interacts with F2LR1/PAR2 (By similarity). Interacts with KDELR2/ERD2; the interaction is disrupted by KDELR2 ligand (By similarity). Found in a complex composed at least of SURF4, TMED2 and TMED10. Associates with the presenilin-dependent gamma-secretase complex. Interacts with STX17; the interaction is direct. Interacts with IL-1; the interaction is direct. Interacts with RAB21 (active GTP-bound form); the interaction is indirect and regulates TMED10 abundance and localization at the Golgi (By similarity). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein Golgi apparatus membrane ; Single-pass type I membrane protein Golgi apparatus, cis-Golgi network membrane ; Single-pass type I membrane protein Golgi apparatus, trans-Golgi network membrane ; Single-pass type I membrane protein Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass type I membrane protein Cell membrane ; Single- pass type I membrane protein Melanosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D1D4-1; Sequence=Displayed; Name=2; IsoId=Q9D1D4-2; Sequence=VSP_013582; The GOLD domain is required for proper p24 heterooligomeric complex formation and efficient transport of GPI-anchored proteins. The lumenal domain mediates localization to the plasma membrane by partially overriding the ER retention by the cytoplasmic domain. Early embryonic lethal. Decreases the protein but not the mRNA level of Tmed3 and Tmed9. Heterozygous Tmed10 +/- mice are viable but show structural deficits in the Golgi morphology, such as the formation of dilated saccules (PubMed:10660306). Conditional knockout mice show a increase in serum interleukin-1 beta (IL1B) and inflammation levels (PubMed:32272059). Ectopic expression of TMED10 alone does not result in its proper cis-Golgi network localization. Interaction of TMED10 with TMED2 is both necessary and sufficient for transport of the couple to the cis-Golgi network, and TMED3 and/or TMED9 contribute to facilitating the process. Belongs to the EMP24/GP25L family. Golgi membrane kidney development endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cis-Golgi network plasma membrane intracellular protein transport ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER Golgi organization protein transport membrane integral component of membrane vesicle-mediated transport syntaxin binding ER to Golgi transport vesicle COPI-coated vesicle trans-Golgi network transport vesicle transport vesicle membrane secretory granule membrane cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment membrane COPI-coated vesicle budding melanosome zymogen granule membrane intracellular membrane-bounded organelle response to alkaloid macromolecular complex binding regulated exocytosis vesicle targeting, to, from or within Golgi protein oligomerization gamma-secretase complex regulation of beta-amyloid formation uc007ogz.1 uc007ogz.2 uc007ogz.3 
ENSMUST00000040772.9 Fermt3 ENSMUST00000040772.9 fermitin family member 3, transcript variant 1 (from RefSeq NM_153795.2) ENSMUST00000040772.1 ENSMUST00000040772.2 ENSMUST00000040772.3 ENSMUST00000040772.4 ENSMUST00000040772.5 ENSMUST00000040772.6 ENSMUST00000040772.7 ENSMUST00000040772.8 Kind3 NM_153795 Q8K1B8 URP2_MOUSE Urp2 uc008gkd.1 uc008gkd.2 uc008gkd.3 Plays a central role in cell adhesion in hematopoietic cells (By similarity). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (PubMed:18278053). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234461). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (PubMed:18278053). Interacts with ITGB1, ITGB2 and ITGB3 (via cytoplasmic tails). Cell projection, podosome Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells. Specifically expressed in hematopoietic cells. The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. Mice suffer from fatal anemia, caused by severe bleeding and erythrocytopenia. Mice also show markedly reduced size and cellularity. Platelets cannot activate integrins despite normal Talin (Tln1) expression. Belongs to the kindlin family. podosome integrin binding protein binding cell adhesion leukocyte cell-cell adhesion integrin-mediated signaling pathway cell junction positive regulation of cell migration integrin activation regulation of cell-cell adhesion mediated by integrin substrate adhesion-dependent cell spreading cell projection platelet aggregation uc008gkd.1 uc008gkd.2 uc008gkd.3 
ENSMUST00000040776.6 Cenpt ENSMUST00000040776.6 centromere protein T (from RefSeq NM_177150.2) CENPT_MOUSE ENSMUST00000040776.1 ENSMUST00000040776.2 ENSMUST00000040776.3 ENSMUST00000040776.4 ENSMUST00000040776.5 NM_177150 Q3TJM4 Q3TPY6 Q3UPD2 Q8BTH0 Q8BTP2 Q8R5E9 uc009nef.1 uc009nef.2 uc009nef.3 Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3- containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Identified in a centromeric complex containing histones H2A, H2B, H3 and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1. Interacts (via N-terminus) with the NDC80 complex. Heterodimer with CENPW; this dimer coassembles with CENPS-CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex. Nucleus Chromosome, centromere Chromosome, centromere, kinetochore Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may connect it to the outer kinetochore via its N-terminus. The largest part of the sequence forms an elongated and flexible stalk structure that is connected to a C-terminal globular domain with a histone-type fold. Dynamically phosphorylated during the cell cycle. Phosphorylated during G2 phase, metaphase and anaphase, but not during telophase or G1 phase. Belongs to the CENP-T/CNN1 family. Sequence=BAC40776.1; Type=Frameshift; Evidence=; mitotic cell cycle chromosome, centromeric region kinetochore condensed chromosome kinetochore DNA binding nucleus chromosome cell cycle chromosome segregation nuclear body protein heterodimerization activity chromosome organization cell division kinetochore assembly uc009nef.1 uc009nef.2 uc009nef.3 
ENSMUST00000040787.13 Ankrd13c ENSMUST00000040787.13 ankyrin repeat domain 13c, transcript variant 2 (from RefSeq NM_001359909.1) AN13C_MOUSE B2RST2 ENSMUST00000040787.1 ENSMUST00000040787.10 ENSMUST00000040787.11 ENSMUST00000040787.12 ENSMUST00000040787.2 ENSMUST00000040787.3 ENSMUST00000040787.4 ENSMUST00000040787.5 ENSMUST00000040787.6 ENSMUST00000040787.7 ENSMUST00000040787.8 ENSMUST00000040787.9 NM_001359909 Q3UX43 Q6P1G4 uc008rvk.1 uc008rvk.2 uc008rvk.3 Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER. Endoplasmic reticulum membrane Note=Associated with the cytosolic side. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UX43-1; Sequence=Displayed; Name=2; IsoId=Q3UX43-2; Sequence=VSP_019409, VSP_019410; receptor binding endoplasmic reticulum endoplasmic reticulum membrane protein retention in ER lumen regulation of receptor biosynthetic process membrane perinuclear region of cytoplasm regulation of anoikis uc008rvk.1 uc008rvk.2 uc008rvk.3 
ENSMUST00000040789.6 Qpct ENSMUST00000040789.6 glutaminyl-peptide cyclotransferase (glutaminyl cyclase), transcript variant 1 (from RefSeq NM_027455.3) A0A0R4J0G6 A0A0R4J0G6_MOUSE ENSMUST00000040789.1 ENSMUST00000040789.2 ENSMUST00000040789.3 ENSMUST00000040789.4 ENSMUST00000040789.5 NM_027455 Qpct uc008dpv.1 uc008dpv.2 uc008dpv.3 Reaction=N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl- [peptide] + NH4(+); Xref=Rhea:RHEA:23652, Rhea:RHEA-COMP:11736, Rhea:RHEA-COMP:11846, ChEBI:CHEBI:28938, ChEBI:CHEBI:64722, ChEBI:CHEBI:87215; EC=2.3.2.5; Evidence=; Secreted Belongs to the glutaminyl-peptide cyclotransferase family. zinc ion binding glutaminyl-peptide cyclotransferase activity peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase uc008dpv.1 uc008dpv.2 uc008dpv.3 
ENSMUST00000040790.14 Slx4 ENSMUST00000040790.14 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae), transcript variant 10 (from RefSeq NR_175318.1) Btbd12 ENSMUST00000040790.1 ENSMUST00000040790.10 ENSMUST00000040790.11 ENSMUST00000040790.12 ENSMUST00000040790.13 ENSMUST00000040790.2 ENSMUST00000040790.3 ENSMUST00000040790.4 ENSMUST00000040790.5 ENSMUST00000040790.6 ENSMUST00000040790.7 ENSMUST00000040790.8 ENSMUST00000040790.9 NR_175318 Q6P1D7 SLX4_MOUSE uc007xzg.1 uc007xzg.2 uc007xzg.3 uc007xzg.4 uc007xzg.5 Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1- SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks (By similarity). Forms a heterodimer with SLX1A/GIYD1. Interacts with ERCC4/XPF; catalytic subunit of the ERCC4-ERCC1 endonuclease. Interacts with MUS81; catalytic subunit of the MUS81-EME1 endonuclease. Interacts with MSH2; component of the MSH2-MSH3 mismatch repair complex. Interacts with TERF2-TERF2IP. Interacts with PLK1 and SLX4IP (By similarity). Nucleus Note=Localizes to sites of DNA damage. Highly expressed in testis. Expressed in bone marrow, brain, thymus and weakly in heart, kidney and spleen. Belongs to the SLX4 family. meiotic DNA double-strand break processing resolution of meiotic recombination intermediates double-strand break repair via homologous recombination chromosome, telomeric region nuclear chromosome, telomeric region nuclear chromatin nucleus nucleoplasm cytosol DNA replication DNA repair nucleotide-excision repair DNA recombination cellular response to DNA damage stimulus enzyme activator activity crossover junction endodeoxyribonuclease activity DNA double-strand break processing involved in repair via single-strand annealing 5'-flap endonuclease activity cell junction Slx1-Slx4 complex interstrand cross-link repair positive regulation of catalytic activity 3'-flap endonuclease activity Holliday junction resolvase complex telomeric D-loop disassembly ERCC4-ERCC1 complex response to intra-S DNA damage checkpoint signaling t-circle formation negative regulation of telomere maintenance via telomere lengthening positive regulation of t-circle formation uc007xzg.1 uc007xzg.2 uc007xzg.3 uc007xzg.4 uc007xzg.5 
ENSMUST00000040791.9 Nipal2 ENSMUST00000040791.9 NIPA-like domain containing 2 (from RefSeq NM_145469.5) A0A0R4J0G3 A0A0R4J0G3_MOUSE ENSMUST00000040791.1 ENSMUST00000040791.2 ENSMUST00000040791.3 ENSMUST00000040791.4 ENSMUST00000040791.5 ENSMUST00000040791.6 ENSMUST00000040791.7 ENSMUST00000040791.8 NM_145469 Nipal2 uc007vlw.1 uc007vlw.2 uc007vlw.3 Membrane ; Multi- pass membrane protein Belongs to the NIPA family. magnesium ion transmembrane transporter activity magnesium ion transport membrane integral component of membrane magnesium ion transmembrane transport uc007vlw.1 uc007vlw.2 uc007vlw.3 
ENSMUST00000040806.5 Dbil5 ENSMUST00000040806.5 diazepam binding inhibitor-like 5 (from RefSeq NM_021294.2) Dbil5 ENSMUST00000040806.1 ENSMUST00000040806.2 ENSMUST00000040806.3 ENSMUST00000040806.4 NM_021294 Q545L5 Q545L5_MOUSE uc007kfk.1 uc007kfk.2 uc007kfk.3 fatty-acyl-CoA binding spermatogenesis uc007kfk.1 uc007kfk.2 uc007kfk.3 
ENSMUST00000040820.13 Maob ENSMUST00000040820.13 monoamine oxidase B (from RefSeq NM_172778.2) AOFB_MOUSE ENSMUST00000040820.1 ENSMUST00000040820.10 ENSMUST00000040820.11 ENSMUST00000040820.12 ENSMUST00000040820.2 ENSMUST00000040820.3 ENSMUST00000040820.4 ENSMUST00000040820.5 ENSMUST00000040820.6 ENSMUST00000040820.7 ENSMUST00000040820.8 ENSMUST00000040820.9 Maob NM_172778 Q14CG9 Q8BW75 Q8C0B2 uc009ssb.1 uc009ssb.2 uc009ssb.3 uc009ssb.4 Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:4156831). Preferentially degrades benzylamine and phenylethylamine (By similarity). Reaction=a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2; Xref=Rhea:RHEA:26414, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478, ChEBI:CHEBI:58855, ChEBI:CHEBI:65296; EC=1.4.3.4; Evidence=; Reaction=(R)-adrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine; Xref=Rhea:RHEA:51168, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:59338, ChEBI:CHEBI:71406, ChEBI:CHEBI:180943; Evidence=; Reaction=an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:16153, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478, ChEBI:CHEBI:28938, ChEBI:CHEBI:58001; EC=1.4.3.21; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16154; Evidence=; Reaction=benzylamine + H2O + O2 = benzaldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:59424, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17169, ChEBI:CHEBI:28938, ChEBI:CHEBI:225238; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59425; Evidence=; Reaction=dopamine + H2O + O2 = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:27946, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:27978, ChEBI:CHEBI:28938, ChEBI:CHEBI:59905; Evidence=; Reaction=H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:30591, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:15621, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:327995; Evidence=; Reaction=(R)-noradrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:69076, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:72587, ChEBI:CHEBI:180943; Evidence=; Reaction=2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:25265, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:16424, ChEBI:CHEBI:28938, ChEBI:CHEBI:225237; Evidence=; Reaction=H2O + N-acetylputrescine + O2 = 4-acetamidobutanal + H2O2 + NH4(+); Xref=Rhea:RHEA:70283, ChEBI:CHEBI:7386, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:58263; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70284; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity). Mitochondrion outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side Belongs to the flavin monoamine oxidase family. mitochondrion mitochondrial outer membrane mitochondrial inner membrane primary amine oxidase activity response to toxic substance response to aluminum ion response to selenium ion negative regulation of serotonin secretion membrane integral component of membrane oxidoreductase activity response to lipopolysaccharide neurotransmitter catabolic process response to drug protein homodimerization activity response to ethanol positive regulation of dopamine metabolic process response to steroid hormone flavin adenine dinucleotide binding response to corticosterone oxidation-reduction process uc009ssb.1 uc009ssb.2 uc009ssb.3 uc009ssb.4 
ENSMUST00000040821.5 Heyl ENSMUST00000040821.5 hairy/enhancer-of-split related with YRPW motif-like (from RefSeq NM_013905.3) ENSMUST00000040821.1 ENSMUST00000040821.2 ENSMUST00000040821.3 ENSMUST00000040821.4 HEYL_MOUSE Hesr3 Hrt3 NM_013905 Q9DBX7 Q9JJV6 Q9QXW8 uc008uoz.1 uc008uoz.2 uc008uoz.3 Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Interacts with HES1, HDAC1, NCOR1 and SIN3A (By similarity). Self-associates. Interacts with GATA4, GATA6, HEY1 and HEY2. Nucleus Expressed in heart and at lower levels in brain, lung, muscle, ovary and testis. Expressed in the presmitic mesoderm, the somites, the developing peripheral nervous system and arterial smooth muscle. Expressed in atrioventricular cushions from 9.5 dpc to 12.5 dpc. Also expressed in developing retina. By activation of the Notch signaling pathway. Expression in nascent somites is reduced in mice lacking Notch signaling. Belongs to the HEY family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding outflow tract morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis cardiac ventricle morphogenesis DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus nucleoplasm transcription factor complex cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Notch signaling pathway multicellular organism development peripheral nervous system development anterior/posterior pattern specification negative regulation of gene expression mesenchymal cell development cell differentiation glomerulus development skeletal muscle cell differentiation protein homodimerization activity negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding positive regulation of neuron differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity AF-1 domain binding regulation of neurogenesis cardiac epithelial to mesenchymal transition ventricular septum morphogenesis negative regulation of androgen receptor signaling pathway cellular response to BMP stimulus proximal tubule development circulatory system development uc008uoz.1 uc008uoz.2 uc008uoz.3 
ENSMUST00000040826.6 Sdhaf3 ENSMUST00000040826.6 succinate dehydrogenase complex assembly factor 3, transcript variant 2 (from RefSeq NM_001077713.2) Acn9 ENSMUST00000040826.1 ENSMUST00000040826.2 ENSMUST00000040826.3 ENSMUST00000040826.4 ENSMUST00000040826.5 NM_001077713 Q8BQU3 Q8BT21 SDHF3_MOUSE Sdhaf3 uc009axa.1 uc009axa.2 uc009axa.3 Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. Interacts with Sdhb within an Sdha-Sdhb subcomplex. Mitochondrion matrix Belongs to the complex I LYR family. SDHAF3 subfamily. molecular_function mitochondrion mitochondrial intermembrane space mitochondrial matrix succinate metabolic process mitochondrial respiratory chain complex II assembly uc009axa.1 uc009axa.2 uc009axa.3 
ENSMUST00000040828.7 H2-Ab1 ENSMUST00000040828.7 histocompatibility 2, class II antigen A, beta 1 (from RefSeq NM_207105.3) ENSMUST00000040828.1 ENSMUST00000040828.2 ENSMUST00000040828.3 ENSMUST00000040828.4 ENSMUST00000040828.5 ENSMUST00000040828.6 H2-Ab1 NM_207105 Q3TD53 Q3TD53_MOUSE Rmcs1 uc008ccb.1 uc008ccb.2 uc008ccb.3 uc008ccb.4 uc008ccb.5 Membrane ; Single- pass type I membrane protein Belongs to the MHC class II family. adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune response membrane integral component of membrane antigen processing and presentation MHC class II protein complex uc008ccb.1 uc008ccb.2 uc008ccb.3 uc008ccb.4 uc008ccb.5 
ENSMUST00000040833.5 Edem2 ENSMUST00000040833.5 ER degradation enhancer, mannosidase alpha-like 2 (from RefSeq NM_145537.2) EDEM2_MOUSE ENSMUST00000040833.1 ENSMUST00000040833.2 ENSMUST00000040833.3 ENSMUST00000040833.4 Edem2 NM_145537 Q8BJR2 Q8BJT9 Q8BK85 Q91VV3 uc008nlg.1 uc008nlg.2 uc008nlg.3 uc008nlg.4 Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15579471, PubMed:25655076). May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (By similarity). Seems to recognize and bind to exposed hydrophobic regions in target proteins (PubMed:25655076). Endoplasmic reticulum lumen Up-regulated by the unfolded protein response (UPR) via the XBP1 transcription factor. N-glycosylated. Belongs to the glycosyl hydrolase 47 family. Has similarity to alpha 1,2-mannosidases, but the catalytic activity of this protein is controversial. One study shows that it is important for a specific oligosaccharide trimming step from Man9GlcNAc2 to Man8GlcNAc2, suggesting activity as a mannosidase. However, another study reports that this protein has no mannosidase activity. catalytic activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity calcium ion binding protein binding endoplasmic reticulum endoplasmic reticulum lumen response to unfolded protein membrane trimming of terminal mannose on B branch endoplasmic reticulum quality control compartment glycoprotein ERAD pathway positive regulation of retrograde protein transport, ER to cytosol mannose trimming involved in glycoprotein ERAD pathway uc008nlg.1 uc008nlg.2 uc008nlg.3 uc008nlg.4 
ENSMUST00000040835.9 Chchd4 ENSMUST00000040835.9 coiled-coil-helix-coiled-coil-helix domain containing 4 (from RefSeq NM_133928.2) ENSMUST00000040835.1 ENSMUST00000040835.2 ENSMUST00000040835.3 ENSMUST00000040835.4 ENSMUST00000040835.5 ENSMUST00000040835.6 ENSMUST00000040835.7 ENSMUST00000040835.8 MIA40_MOUSE Mia40 NM_133928 Q8VEA4 uc009cyb.1 uc009cyb.2 uc009cyb.3 Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (PubMed:26004228). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake. Monomer. Can form homooligomers. Interacts with GFER and forms transient disulfide bonds with GFER. Interacts with MICU1. Interacts with COX19 forming transient intermolecular disulfide bridges. Interacts with COA7 through transient intermolecular disulfide bonds. Interacts with AIFM1; the interaction increases in presence of NADH. Interacts with NDUFB10. Mitochondrion intermembrane space Widely expressed. Present at high level in liver and kidney, followed by lung, brain, heart and spleen (at protein level). The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria. Forms intrachain disulfide bridges, but exists in different redox states. Mutants have a developmental arrest coupled with embryonic lethality at 8.5 dpc. They show a major defect in the expression of respiratory chain complex I subunit NDUFS7/CI-20. protein binding mitochondrion mitochondrial intermembrane space protein transport protein disulfide oxidoreductase activity oxidoreductase activity peptidyl-cysteine oxidation protein maturation by protein folding cellular response to oxidative stress mitochondrial DNA repair protein import into mitochondrial intermembrane space regulation of protein export from nucleus 'de novo' posttranslational protein folding oxidation-reduction process establishment of protein localization to mitochondrion positive regulation of cellular respiration cellular response to leukemia inhibitory factor uc009cyb.1 uc009cyb.2 uc009cyb.3 
ENSMUST00000040844.16 Ankrd27 ENSMUST00000040844.16 ankyrin repeat domain 27, transcript variant 4 (from RefSeq NR_152519.1) ANR27_MOUSE ENSMUST00000040844.1 ENSMUST00000040844.10 ENSMUST00000040844.11 ENSMUST00000040844.12 ENSMUST00000040844.13 ENSMUST00000040844.14 ENSMUST00000040844.15 ENSMUST00000040844.2 ENSMUST00000040844.3 ENSMUST00000040844.4 ENSMUST00000040844.5 ENSMUST00000040844.6 ENSMUST00000040844.7 ENSMUST00000040844.8 ENSMUST00000040844.9 NR_152519 Q3UMR0 Q6KAU0 Q6P1F9 Q7TNY8 Q8BUD2 Q91W65 Varp uc009gkd.1 uc009gkd.2 uc009gkd.3 May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (By similarity). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (By similarity). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (PubMed:19403694, PubMed:21187289). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (PubMed:19745841, PubMed:22171327). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1. Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (By similarity). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (By similarity). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560). Interacts with RAB21 (GDP-bound form), VPS29, KIF5A, KIF5C, GOLGA4 (By similarity). Interacts with RAB32 (GTP-bound form), RAB38 (GTP-bound form), VAMP7 (PubMed:19403694, PubMed:21187289). Interacts with low affinity with RAB5 (By similarity). ANKRD27:RAB32 heterodimers can homodimerize to form tetramers (By similarity). Can interact with RAB38 or RAB32, VPS29 and VAMP7 simultaneously (By similarity). A decreased interaction with RAB32 seen in the presence of SGSM2 (By similarity). Q3UMR0; Q8QZZ8: Rab38; NbExp=5; IntAct=EBI-1993429, EBI-1993463; Early endosome Late endosome Cytoplasmic vesicle membrane Lysosome Cell membrane Melanosome Cytoplasmic vesicle Note=Colocalizes with VAMP7 in transport vesicles in the shaft of hippocampal neurons. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UMR0-1; Sequence=Displayed; Name=2; IsoId=Q3UMR0-2; Sequence=VSP_022792; Name=3; IsoId=Q3UMR0-3; Sequence=VSP_022791; Sequence=AAP94281.1; Type=Frameshift; Evidence=; SNARE binding guanyl-nucleotide exchange factor activity GTPase activator activity protein binding lysosome endosome early endosome late endosome cytosol plasma membrane positive regulation of neuron projection development protein transport membrane Rab GTPase binding transport vesicle cytoplasmic vesicle membrane cytoplasmic vesicle negative regulation of SNARE complex assembly endosome to melanosome transport melanosome neuron projection positive regulation of GTPase activity early endosome to late endosome transport neuron projection morphogenesis positive regulation of dendrite morphogenesis tubular endosome retrograde transport, endosome to plasma membrane uc009gkd.1 uc009gkd.2 uc009gkd.3 
ENSMUST00000040853.11 Oxsr1 ENSMUST00000040853.11 oxidative-stress responsive 1, transcript variant 2 (from RefSeq NR_045693.1) ENSMUST00000040853.1 ENSMUST00000040853.10 ENSMUST00000040853.2 ENSMUST00000040853.3 ENSMUST00000040853.4 ENSMUST00000040853.5 ENSMUST00000040853.6 ENSMUST00000040853.7 ENSMUST00000040853.8 ENSMUST00000040853.9 NR_045693 OXSR1_MOUSE Osr1 Oxsr1 Q6P9R2 Q8BVZ9 Q8C0B9 uc009saq.1 uc009saq.2 uc009saq.3 uc009saq.4 Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:17488636, PubMed:19633012, PubMed:21486947). Specifically recognizes and binds proteins with a RFXV motif (By similarity). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:12386165, PubMed:16382158, PubMed:17488636, PubMed:19633012, PubMed:21486947). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16382158, PubMed:21972418). Phosphorylation of Na- K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16382158). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:17488636, PubMed:19633012). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:21972418). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (By similarity). Phosphorylates RELL1, RELL2, RELT and PAK1 (By similarity). Phosphorylates PLSCR1 in the presence of RELT (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated following phosphorylation at Thr-185 by WNK kinases (WNK1, WNK2, WNK3 or WNK4). Cytoplasm Ubiquitously expressed in all tissues examined, except thymus. Phosphorylation at Thr-185 by WNK kinases (WNK1, WNK2, WNK3 or WNK4) is required for activation (PubMed:21486947). Autophosphorylated; promoting its activity (By similarity). Embryonic lethality caused by angiogenesis and cardiac defects beginning at 10.5 dpc (PubMed:23386621). Conditional deletion in endothelial cells leads to cardiovascular developmental defects, leading to embryonic lethality (PubMed:23386621). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Sequence=BAC27551.1; Type=Erroneous initiation; Evidence=; Sequence=BAC35996.1; Type=Erroneous initiation; Evidence=; nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm cytosol protein phosphorylation response to oxidative stress osmosensory signaling pathway positive regulation of T cell chemotaxis kinase activity phosphorylation transferase activity peptidyl-threonine phosphorylation protein kinase binding signal transduction by protein phosphorylation signal transduction by trans-phosphorylation activation of protein kinase activity intracellular signal transduction chemokine (C-C motif) ligand 21 signaling pathway chemokine (C-X-C motif) ligand 12 signaling pathway identical protein binding protein autophosphorylation metal ion binding cellular hypotonic response negative regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transport cellular response to chemokine uc009saq.1 uc009saq.2 uc009saq.3 uc009saq.4 
ENSMUST00000040856.3 Tmco5b ENSMUST00000040856.3 transmembrane and coiled-coil domains 5B (from RefSeq NM_029232.2) ENSMUST00000040856.1 ENSMUST00000040856.2 NM_029232 Q80X59 Q9D4S7 TMC5B_MOUSE uc008lpj.1 uc008lpj.2 Membrane ; Single-pass membrane protein Belongs to the TMCO5 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008lpj.1 uc008lpj.2 
ENSMUST00000040860.3 Psma8 ENSMUST00000040860.3 proteasome subunit alpha 8, transcript variant 1 (from RefSeq NM_001163609.1) ENSMUST00000040860.1 ENSMUST00000040860.2 NM_001163609 PSMA8_MOUSE Psma7l Psma8 Q14A44 Q9CWH6 uc008edj.1 uc008edj.2 uc008edj.3 uc008edj.4 Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis (PubMed:23706739, PubMed:31358751, PubMed:31437213). The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds (Probable). Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis (PubMed:31358751). Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I (PubMed:31437213). Component of the outer alpha-ring of the 20S proteasome core which is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure (PubMed:23706739, PubMed:31358751). The catalytic chamber with the active sites is on the inside of the barrel (Probable). Interacts with canonical subunits of the spermatoproteasome, including proteasome activators PSME4 (also called PA200) and PSME3 (also called PA28-gamma) (PubMed:31437213). Interacts with proteasome-interacting proteins chaperones including CCT6B and CCT2, ubiquitin ligases (TRIP12, NEDD4, TRIM36 and RAD18), and ubiquitin specific proteases such as USP9X, USP34, USP5 and USP47 (PubMed:31437213). Interacts with meiotic proteins cyclin dependent kinase CDK1 and the ATPase TRIP13 as well as proteins of the synaptonemal complex SIX6OS1 and SYCE3 (PubMed:31437213). Nucleus Note=Localizes to the central region of the synaptonemal complex. In testes, expressed in spermatocytes at the pachytene stage (weakly in early pachynema and strongly in late pachynema), and its expression persisted thereafter throughout spermatogenesis. Knockout mice were obtained according to the expected Mendelian ratios and showed no obvious phenotypes with respect to viability and development; however males show infertility (PubMed:31358751, PubMed:31437213). PSMA8-null spermatocytes exhibit delayed M-phase entry and are finally arrested at this stage, resulting in male infertility (PubMed:31358751, PubMed:31437213). Belongs to the peptidase T1A family. Predicted to have endopeptidase activity (By similarity). However, as it is located in the outer alpha-ring, it is suggested to lack catalytic activity and preferentially interact with regulatory complexes such as PSME4/PA200. proteasome complex endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteolysis ubiquitin-dependent protein catabolic process peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, alpha-subunit complex proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process spermatoproteasome complex uc008edj.1 uc008edj.2 uc008edj.3 uc008edj.4 
ENSMUST00000040865.9 Tmem98 ENSMUST00000040865.9 transmembrane protein 98 (from RefSeq NM_029537.2) ENSMUST00000040865.1 ENSMUST00000040865.2 ENSMUST00000040865.3 ENSMUST00000040865.4 ENSMUST00000040865.5 ENSMUST00000040865.6 ENSMUST00000040865.7 ENSMUST00000040865.8 NM_029537 Q91X86 TMM98_MOUSE uc007kmj.1 uc007kmj.2 uc007kmj.3 Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation (PubMed:25946230). The secreted form promotes differentiation of T helper 1 cells (Th1) (PubMed:25946230). Interacts (via N-terminal region) with MYRF; the interaction inhibits MYRF self-cleavage. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Cell membrane ; Single-pass type II membrane protein Secreted Secreted, extracellular exosome Note=Secreted by exosomes through a non-classical pathway. Expressed in differentiated oligodendrocytes in early postanatal central nervous system tissues (PubMed:30249802). Expressed by CD4(+) T cells, the expression increases upon activation (at protein level) (PubMed:25946230). In the spinal cord region, expression is initially detected in the ventral white matter at 18.5 dpc, up-regulates rapidly afterward, and peaks at early postnatal stages from P4 to P7. At P15, expression starts to be detected in the gray matter of spinal cord but gradually disappears thereafter. Also observed in corpus callosum and the white matter of cerebellum at P15 stages. Belongs to the TMEM98 family. protein binding extracellular region extracellular space endoplasmic reticulum endoplasmic reticulum membrane plasma membrane negative regulation of protein processing membrane integral component of membrane negative regulation of myelination T-helper 1 cell differentiation negative regulation of oligodendrocyte differentiation extracellular exosome negative regulation of protein localization to nucleus uc007kmj.1 uc007kmj.2 uc007kmj.3 
ENSMUST00000040876.7 Ak7 ENSMUST00000040876.7 adenylate kinase 7 (from RefSeq NM_030187.1) Ak7 ENSMUST00000040876.1 ENSMUST00000040876.2 ENSMUST00000040876.3 ENSMUST00000040876.4 ENSMUST00000040876.5 ENSMUST00000040876.6 F8WIC0 F8WIC0_MOUSE NM_030187 uc007oyt.1 uc007oyt.2 uc007oyt.3 adenylate kinase activity cytidylate kinase activity nucleoside diphosphate kinase activity ATP binding nucleobase-containing compound metabolic process nucleoside diphosphate phosphorylation nucleoside triphosphate biosynthetic process nucleobase-containing compound kinase activity nucleoside monophosphate phosphorylation uc007oyt.1 uc007oyt.2 uc007oyt.3 
ENSMUST00000040880.9 Map6d1 ENSMUST00000040880.9 MAP6 domain containing 1 (from RefSeq NM_198599.2) ENSMUST00000040880.1 ENSMUST00000040880.2 ENSMUST00000040880.3 ENSMUST00000040880.4 ENSMUST00000040880.5 ENSMUST00000040880.6 ENSMUST00000040880.7 ENSMUST00000040880.8 MA6D1_MOUSE NM_198599 Q14BB9 Q3TQE2 Q8C540 uc007ypk.1 uc007ypk.2 uc007ypk.3 May have microtubule-stabilizing activity. Interacts with calmodulin. Golgi apparatus Cytoplasm, cytoskeleton Note=According to PubMed:16837464, it colocalizes with microtubules. Expressed in brain. Found in neurons in primary cultures, but absent in glial cells. Palmitoylated. Palmitoylation enhances association with microtubules (By similarity). Belongs to the STOP family. Sequence=BAC37698.1; Type=Frameshift; Evidence=; Sequence=BAE37442.1; Type=Erroneous initiation; Evidence=; Sequence=BAE37442.1; Type=Frameshift; Evidence=; microtubule cytoskeleton organization calmodulin binding cytoplasm Golgi apparatus Golgi-associated vesicle cis-Golgi network cytoskeleton microtubule negative regulation of microtubule depolymerization microtubule binding N-terminal peptidyl-L-cysteine N-palmitoylation cytoskeleton-dependent intracellular transport regulation of microtubule cytoskeleton organization uc007ypk.1 uc007ypk.2 uc007ypk.3 
ENSMUST00000040881.14 Cluap1 ENSMUST00000040881.14 clusterin associated protein 1, transcript variant 14 (from RefSeq NR_185002.1) CLUA1_MOUSE ENSMUST00000040881.1 ENSMUST00000040881.10 ENSMUST00000040881.11 ENSMUST00000040881.12 ENSMUST00000040881.13 ENSMUST00000040881.2 ENSMUST00000040881.3 ENSMUST00000040881.4 ENSMUST00000040881.5 ENSMUST00000040881.6 ENSMUST00000040881.7 ENSMUST00000040881.8 ENSMUST00000040881.9 NR_185002 Q6P3Y8 Q8R3P7 uc007xzb.1 uc007xzb.2 uc007xzb.3 Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. Interacts with CLU/clusterin. Interacts with UBXN10; the interaction is direct. Cell projection, cilium Nucleus Expressed in all tissues tested including heart, kidney, skeletal muscle, eye, liver, ovary, oviduct, testes, lung and brain. Elevated levels in multiciliated cells such as the bronchioles of the lungs, ependymal cells of the brain and cells with a single primary cilia of heart and kidney. E9.5 embryos are still viable but die thereafter. Mutant embryos are runted, have exhibit enlarged pericardial sacs, and defects in neural tube development. There is a complete absence of cilia in E9.5 embryos. Sonic hedgehog (SHH) signaling is severely disrupted with down-regulation of PTCH1 and GLI1. Belongs to the CLUAP1 family. neural tube closure heart looping molecular_function nucleus nucleoplasm centrosome cilium smoothened signaling pathway floor plate formation cell projection organization intraciliary transport particle B axoneme assembly intraciliary transport cell projection intracellular membrane-bounded organelle cilium assembly left/right pattern formation ciliary tip ciliary base axoneme uc007xzb.1 uc007xzb.2 uc007xzb.3 
ENSMUST00000040888.12 Krtcap2 ENSMUST00000040888.12 keratinocyte associated protein 2, transcript variant 1 (from RefSeq NM_025327.3) ENSMUST00000040888.1 ENSMUST00000040888.10 ENSMUST00000040888.11 ENSMUST00000040888.2 ENSMUST00000040888.3 ENSMUST00000040888.4 ENSMUST00000040888.5 ENSMUST00000040888.6 ENSMUST00000040888.7 ENSMUST00000040888.8 ENSMUST00000040888.9 KTAP2_MOUSE NM_025327 Q5RL79 Q9CQK5 uc008pyl.1 uc008pyl.2 uc008pyl.3 uc008pyl.4 Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid- beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. Protein modification; protein glycosylation. Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Interacts with PSEN1 and NCSTN; indicative for an association with the gamma-secretase complex (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the KRTCAP2 family. Sequence=AAH43030.1; Type=Erroneous initiation; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation membrane integral component of membrane protein N-linked glycosylation via asparagine protein N-linked glycosylation via arginine oligosaccharyltransferase complex dolichyl-diphosphooligosaccharide-protein glycotransferase activity uc008pyl.1 uc008pyl.2 uc008pyl.3 uc008pyl.4 
ENSMUST00000040907.8 Decr2 ENSMUST00000040907.8 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal, transcript variant 13 (from RefSeq NR_177215.1) DECR2_MOUSE ENSMUST00000040907.1 ENSMUST00000040907.2 ENSMUST00000040907.3 ENSMUST00000040907.4 ENSMUST00000040907.5 ENSMUST00000040907.6 ENSMUST00000040907.7 NR_177215 Pdcr Q9WV68 uc008bdg.1 uc008bdg.2 uc008bdg.3 uc008bdg.4 Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. Reaction=a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)- enoyl-CoA + NADP(+); Xref=Rhea:RHEA:61892, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:85099, ChEBI:CHEBI:85493; EC=1.3.1.124; Evidence=; Reaction=a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)- enoyl-CoA + NADP(+); Xref=Rhea:RHEA:45912, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:85101, ChEBI:CHEBI:85493; EC=1.3.1.124; Evidence=; Reaction=(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (3E)-hexenoyl-CoA + NADP(+); Xref=Rhea:RHEA:44912, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:84788, ChEBI:CHEBI:84790; Evidence=; Reaction=(2E,4E)-decadienoyl-CoA + H(+) + NADPH = (3E)-decenoyl-CoA + NADP(+); Xref=Rhea:RHEA:44916, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62244, ChEBI:CHEBI:84793; Evidence=; Reaction=(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+); Xref=Rhea:RHEA:44920, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:77559, ChEBI:CHEBI:84791; Evidence=; Kinetic parameters: KM=108 uM for 2,4-hexadienoyl-CoA ; KM=6 uM for 2,4-decadienoyl-CoA ; KM=155 uM for 2,4,7,10,13,16,19-docosaheptaenoyl-CoA ; Vmax=8 nmol/min/mg enzyme with 2,4-hexadienoyl-CoA as substrate ; Vmax=20 nmol/min/mg enzyme with 2,4-decadienoyl-CoA as substrate ; Vmax=5 nmol/min/mg enzyme with 2,4,7,10,13,16,19-docosaheptaenoyl-CoA as substrate ; Monomer, dimer and oligomer. Peroxisome Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily. peroxisome peroxisomal membrane lipid metabolic process fatty acid metabolic process unsaturated fatty acid biosynthetic process 2,4-dienoyl-CoA reductase (NADPH) activity oxidoreductase activity trans-2-enoyl-CoA reductase (NADPH) activity oxidation-reduction process uc008bdg.1 uc008bdg.2 uc008bdg.3 uc008bdg.4 
ENSMUST00000040912.9 Anln ENSMUST00000040912.9 anillin, actin binding protein, transcript variant 2 (from RefSeq NM_028390.4) ANLN_MOUSE ENSMUST00000040912.1 ENSMUST00000040912.2 ENSMUST00000040912.3 ENSMUST00000040912.4 ENSMUST00000040912.5 ENSMUST00000040912.6 ENSMUST00000040912.7 ENSMUST00000040912.8 NM_028390 Q8BL79 Q8BLB3 Q8K298 Q8K2N0 Q9CUY0 uc009ook.1 uc009ook.2 uc009ook.3 uc009ook.4 Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration. Interacts with F-actin. Interacts with CD2AP. May interact with RHOA. Interacts with FZR1/CDH1 during mitotic exit. Nucleus Cytoplasm, cytoskeleton Cytoplasm, cell cortex Cell projection, bleb Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody. Phosphorylated during mitosis. Ubiquitinated, and this requires FZR1/CDH1. Sequence=AAH30489.1; Type=Erroneous initiation; Evidence=; Sequence=BAC32605.1; Type=Erroneous initiation; Evidence=; mitotic cytokinesis actomyosin contractile ring assembly hematopoietic progenitor cell differentiation actin binding nucleus nucleoplasm cytoplasm actomyosin contractile ring cytoskeleton cell cortex cell cycle actin cytoskeleton GTP-Rho binding midbody cortical cytoskeleton organization septin ring organization bleb cell projection cell division glomerular visceral epithelial cell migration cell cortex region positive regulation of bleb assembly protein localization to actomyosin contractile ring involved in mitotic cytokinesis uc009ook.1 uc009ook.2 uc009ook.3 uc009ook.4 
ENSMUST00000040914.3 H1f2 ENSMUST00000040914.3 H1.2 linker histone, cluster member (from RefSeq NM_015786.3) ENSMUST00000040914.1 ENSMUST00000040914.2 H1f2 Hist1h1c NM_015786 Q5SZA3 Q5SZA3_MOUSE uc007puq.1 uc007puq.2 uc007puq.3 uc007puq.4 uc007puq.5 Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Feb 2014]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: CA468737.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Chromosome Nucleus Belongs to the histone H1/H5 family. nucleosome DNA binding nucleus chromosome nuclear euchromatin nucleosome assembly chromatin DNA binding uc007puq.1 uc007puq.2 uc007puq.3 uc007puq.4 uc007puq.5 
ENSMUST00000040917.14 Rps27l ENSMUST00000040917.14 ribosomal protein S27-like, transcript variant 2 (from RefSeq NM_026467.5) ENSMUST00000040917.1 ENSMUST00000040917.10 ENSMUST00000040917.11 ENSMUST00000040917.12 ENSMUST00000040917.13 ENSMUST00000040917.2 ENSMUST00000040917.3 ENSMUST00000040917.4 ENSMUST00000040917.5 ENSMUST00000040917.6 ENSMUST00000040917.7 ENSMUST00000040917.8 ENSMUST00000040917.9 NM_026467 Q3UB68 Q6ZWY3 RS27L_MOUSE Rps27l uc009qfm.1 uc009qfm.2 uc009qfm.3 uc009qfm.4 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Belongs to the eukaryotic ribosomal protein eS27 family. ribosomal small subunit assembly structural constituent of ribosome nucleus ribosome translation activation of cysteine-type endopeptidase activity involved in apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator translation activator activity cysteine-type endopeptidase activator activity involved in apoptotic process cytosolic small ribosomal subunit mitotic G1 DNA damage checkpoint intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of translation metal ion binding uc009qfm.1 uc009qfm.2 uc009qfm.3 uc009qfm.4 
ENSMUST00000040925.4 Sdr16c5 ENSMUST00000040925.4 short chain dehydrogenase/reductase family 16C, member 5 (from RefSeq NM_181989.1) ENSMUST00000040925.1 ENSMUST00000040925.2 ENSMUST00000040925.3 NM_181989 Q7TQA3 RDHE2_MOUSE Rdhe2 Scdr9 Sdr16c5 uc008rwx.1 uc008rwx.2 uc008rwx.3 Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH. Reaction=all-trans-retinol--[retinol-binding protein] + NAD(+) = all- trans-retinal--[retinol-binding protein] + H(+) + NADH; Xref=Rhea:RHEA:48488, Rhea:RHEA-COMP:14428, Rhea:RHEA-COMP:14430, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83228; EC=1.1.1.105; Evidence=; Cofactor metabolism; retinol metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the short-chain dehydrogenases/reductases (SDR) family. negative regulation of transcription from RNA polymerase II promoter transcription corepressor activity retinol dehydrogenase activity nucleus endoplasmic reticulum endoplasmic reticulum membrane lipid particle transcription factor binding membrane integral component of membrane oxidoreductase activity transcriptional repressor complex positive regulation of histone deacetylation activating transcription factor binding negative regulation of histone acetylation retinol metabolic process retinal metabolic process keratinocyte proliferation oxidation-reduction process chromatin plasma membrane uc008rwx.1 uc008rwx.2 uc008rwx.3 
ENSMUST00000040941.3 Erv3 ENSMUST00000040941.3 endogenous retroviral sequence 3 (from RefSeq NM_001166206.1) ENSMUST00000040941.1 ENSMUST00000040941.2 Erv3 NM_001166206 Q9DAX3 Q9DAX3_MOUSE uc008mlx.1 uc008mlx.2 uc008mlx.3 molecular_function cellular_component biological_process uc008mlx.1 uc008mlx.2 uc008mlx.3 
ENSMUST00000040944.9 Cyp2g1 ENSMUST00000040944.9 cytochrome P450, family 2, subfamily g, polypeptide 1 (from RefSeq NM_013809.1) Cyp2g1 ENSMUST00000040944.1 ENSMUST00000040944.2 ENSMUST00000040944.3 ENSMUST00000040944.4 ENSMUST00000040944.5 ENSMUST00000040944.6 ENSMUST00000040944.7 ENSMUST00000040944.8 NM_013809 Q9WV19 Q9WV19_MOUSE uc009fuu.1 uc009fuu.2 uc009fuu.3 Cytochromes P450 are a group of heme-thiolate monooxygenases. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane Microsome membrane Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding protein binding cytoplasm organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc009fuu.1 uc009fuu.2 uc009fuu.3 
ENSMUST00000040960.13 Slc6a20a ENSMUST00000040960.13 solute carrier family 6 (neurotransmitter transporter), member 20A (from RefSeq NM_139142.2) ENSMUST00000040960.1 ENSMUST00000040960.10 ENSMUST00000040960.11 ENSMUST00000040960.12 ENSMUST00000040960.2 ENSMUST00000040960.3 ENSMUST00000040960.4 ENSMUST00000040960.5 ENSMUST00000040960.6 ENSMUST00000040960.7 ENSMUST00000040960.8 ENSMUST00000040960.9 NM_139142 Q3USE2 Q8VDB9 S620A_MOUSE Slc6a20 Slc6a20a Xt3s1 Xtm3s1 Xtrp3s1 uc009sgk.1 uc009sgk.2 uc009sgk.3 Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids (PubMed:15689184). Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents (PubMed:33428810). Reaction=chloride(out) + L-proline(out) + 2 Na(+)(out) = chloride(in) + L-proline(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71263, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:60039; Evidence=; Reaction=4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) = 4- hydroxy-L-proline + chloride(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72223, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:58419; Evidence=; Reaction=2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) = 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72235, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:192077; Evidence=; Reaction=chloride(out) + L-pipecolate(out) + 2 Na(+)(out) = chloride(in) + L-pipecolate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71267, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:61185; Evidence=; Reaction=chloride(out) + glycine betaine(out) + 2 Na(+)(out) = chloride(in) + glycine betaine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70735, ChEBI:CHEBI:17750, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101; Evidence=; Reaction=chloride(out) + glycine(out) + 2 Na(+)(out) = chloride(in) + glycine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70691, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57305; Evidence=; Kinetic parameters: KM=19.64 uM for proline ; KM=63.16 uM for glycine ; Apical cell membrane ; Multi-pass membrane protein Note=Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi. Expressed in brain, kidney, small intestine, thymus, spleen and lung. In the brain, expressed in cerebellum, cortex and brain stem. Not detected in liver, muscle or heart (PubMed:15689184). In brain, widespread in various regions, including the meninges, choroid plexus, cortex, hippocampus and thalamus (PubMed:33428810). Expression in kidney is highly induced 3 days after birth. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily. neurotransmitter:sodium symporter activity plasma membrane integral component of plasma membrane amino acid transport amino acid transmembrane transporter activity L-proline transmembrane transporter activity symporter activity glycine transport proline transport amino-acid betaine transport membrane integral component of membrane apical plasma membrane proline transmembrane transport uc009sgk.1 uc009sgk.2 uc009sgk.3 
ENSMUST00000040961.3 Pabpc5 ENSMUST00000040961.3 poly(A) binding protein, cytoplasmic 5 (from RefSeq NM_053114.2) ENSMUST00000040961.1 ENSMUST00000040961.2 NM_053114 Pabpc5 Q8C7D3 Q8C7D3_MOUSE uc009ued.1 uc009ued.2 Nucleus nucleic acid binding RNA binding mRNA 3'-UTR binding nucleus cytoplasm cytosol poly(A) binding biological_process poly(U) RNA binding cytoplasmic stress granule ribonucleoprotein complex uc009ued.1 uc009ued.2 
ENSMUST00000040962.6 Nudt19 ENSMUST00000040962.6 nudix hydrolase 19 (from RefSeq NM_033080.2) B2RS21 D7Rp2e ENSMUST00000040962.1 ENSMUST00000040962.2 ENSMUST00000040962.3 ENSMUST00000040962.4 ENSMUST00000040962.5 NM_033080 NUD19_MOUSE P11930 uc009gka.1 uc009gka.2 uc009gka.3 Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'- bisphosphate (PubMed:16185196, PubMed:29378847). Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (PubMed:16185196, PubMed:29378847). Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (PubMed:16185196). Exhibits decapping activity towards dpCoA- capped RNAs in vitro (PubMed:32432673). Reaction=an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'- phosphopantetheine + 2 H(+); Xref=Rhea:RHEA:50044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58342, ChEBI:CHEBI:58343, ChEBI:CHEBI:132023; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50045; Evidence=; Reaction=CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'- bisphosphate + 2 H(+); Xref=Rhea:RHEA:64988, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58343, ChEBI:CHEBI:61723; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64989; Evidence=; Reaction=H2O + hexanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:49980, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58343, ChEBI:CHEBI:62620, ChEBI:CHEBI:132012; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49981; Evidence=; Reaction=H2O + octanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50016, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57386, ChEBI:CHEBI:58343, ChEBI:CHEBI:132013; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50017; Evidence=; Reaction=butanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:49976, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57371, ChEBI:CHEBI:58343, ChEBI:CHEBI:132011; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49977; Evidence=; Reaction=H2O + propanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:67464, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57392, ChEBI:CHEBI:58343, ChEBI:CHEBI:172362; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67465; Evidence=; Reaction=H2O + malonyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine; Xref=Rhea:RHEA:67468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57384, ChEBI:CHEBI:58343, ChEBI:CHEBI:172363; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67469; Evidence=; Reaction=H2O + succinyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine; Xref=Rhea:RHEA:67472, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57292, ChEBI:CHEBI:58343, ChEBI:CHEBI:172364; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67473; Evidence=; Reaction=choloyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S- choloyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50036, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57373, ChEBI:CHEBI:58343, ChEBI:CHEBI:132020; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50037; Evidence=; Reaction=4,8-dimethylnonanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine; Xref=Rhea:RHEA:67524, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58343, ChEBI:CHEBI:77061, ChEBI:CHEBI:172385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67525; Evidence=; Reaction=(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = adenosine 3',5'- bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'- phosphopantetheine; Xref=Rhea:RHEA:67532, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58343, ChEBI:CHEBI:74034, ChEBI:CHEBI:172386; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67533; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + H2O = adenosine 3',5'- bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'- phosphopantetheine; Xref=Rhea:RHEA:67536, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57383, ChEBI:CHEBI:58343, ChEBI:CHEBI:172387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67537; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine; Xref=Rhea:RHEA:67540, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58343, ChEBI:CHEBI:61540, ChEBI:CHEBI:172388; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67541; Evidence=; Reaction=(9Z)-tetradecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine; Xref=Rhea:RHEA:67544, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58343, ChEBI:CHEBI:65060, ChEBI:CHEBI:172389; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67545; Evidence=; Reaction=(6Z)-octenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine; Xref=Rhea:RHEA:67528, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58343, ChEBI:CHEBI:172383, ChEBI:CHEBI:172384; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67529; Evidence=; Reaction=H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50032, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57379, ChEBI:CHEBI:58343, ChEBI:CHEBI:132018; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50033; Evidence=; Reaction=H2O + tetradecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50028, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57385, ChEBI:CHEBI:58343, ChEBI:CHEBI:132017; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50029; Evidence=; Reaction=dodecanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50024, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57375, ChEBI:CHEBI:58343, ChEBI:CHEBI:132015; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50025; Evidence=; Reaction=a 5'-end CoA-ribonucleoside in mRNA + H2O = (R)-4'- phosphopantetheine + a 5'-end phospho-adenosine-phospho- ribonucleoside in mRNA + 2 H(+); Xref=Rhea:RHEA:67592, Rhea:RHEA- COMP:15719, Rhea:RHEA-COMP:17276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:61723, ChEBI:CHEBI:144051, ChEBI:CHEBI:172371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67593; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Inhibited by chenodeoxycholic acid (CDCA) and its conjugated derivatives, taurochenodeoxycholic acid and glycochenodeoxycholic acid (PubMed:29378847). Inhibited by fluoride (PubMed:16185196). Kinetic parameters: KM=0.6 mM for CoA ; KM=0.58 mM for oxidized CoA ; KM=0.08 mM for lauroyl-CoA ; KM=0.01 mM for palmitoyl-CoA ; KM=0.1 mM for choloyl-CoA ; KM=0.1 mM for pristanoyl-CoA ; KM=300 uM for CoA ; Vmax=0.56 umol/min/mg enzyme with CoA as substrate ; Vmax=0.012 umol/min/mg enzyme with oxidized CoA as substrate ; Vmax=0.2 umol/min/mg enzyme with lauroyl-CoA as substrate ; Vmax=0.013 umol/min/mg enzyme with palmitoyl-CoA as substrate ; Vmax=0.17 umol/min/mg enzyme with choloyl-CoA as substrate ; Vmax=0.009 umol/min/mg enzyme with pristanoyl-CoA as substrate ; pH dependence: Optimum pH is 9.0. ; Monomer. Peroxisome Highly expressed in the kidneys, with lower levels in skeletal muscle and brain (at protein level). By testosterone. Mice exhibit a significant 20% increase in total CoA levels in kidney. Belongs to the Nudix hydrolase family. mitochondrion peroxisome hydrolase activity metal ion binding uc009gka.1 uc009gka.2 uc009gka.3 
ENSMUST00000040967.9 Vps37b ENSMUST00000040967.9 vacuolar protein sorting 37B (from RefSeq NM_177876.4) ENSMUST00000040967.1 ENSMUST00000040967.2 ENSMUST00000040967.3 ENSMUST00000040967.4 ENSMUST00000040967.5 ENSMUST00000040967.6 ENSMUST00000040967.7 ENSMUST00000040967.8 NM_177876 Q3TLR2 Q3UDW1 Q8R0J7 VP37B_MOUSE uc008zot.1 uc008zot.2 uc008zot.3 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity). Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with CEP55. Interacts with IST1 (By similarity). Late endosome membrane ; Peripheral membrane protein Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion. Belongs to the VPS37 family. ESCRT I complex cytoplasm endosome plasma membrane protein targeting to membrane protein targeting to vacuole endosome membrane protein transport membrane midbody late endosome membrane endosome transport via multivesicular body sorting pathway ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway intracellular membrane-bounded organelle calcium-dependent protein binding positive regulation of viral release from host cell positive regulation of viral budding via host ESCRT complex uc008zot.1 uc008zot.2 uc008zot.3 
ENSMUST00000040971.14 Capn5 ENSMUST00000040971.14 calpain 5, transcript variant 1 (from RefSeq NM_007602.4) Capn5 ENSMUST00000040971.1 ENSMUST00000040971.10 ENSMUST00000040971.11 ENSMUST00000040971.12 ENSMUST00000040971.13 ENSMUST00000040971.2 ENSMUST00000040971.3 ENSMUST00000040971.4 ENSMUST00000040971.5 ENSMUST00000040971.6 ENSMUST00000040971.7 ENSMUST00000040971.8 ENSMUST00000040971.9 NM_007602 Q3TPL4 Q3TPL4_MOUSE uc009ikd.1 uc009ikd.2 uc009ikd.3 The protein encoded by this gene is a member of the calpain family of proteins. Unlike many members of the calpain gene family, this gene lacks a calmodulin-like domain, required for calcium binding. Mouse models for Huntington's disease displayed increased levels of the protein encoded by this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. Belongs to the peptidase C2 family. calcium-dependent cysteine-type endopeptidase activity proteolysis peptidase activity cysteine-type peptidase activity cell surface hydrolase activity uc009ikd.1 uc009ikd.2 uc009ikd.3 
ENSMUST00000040972.4 Utp15 ENSMUST00000040972.4 UTP15 small subunit processome component (from RefSeq NM_178918.3) ENSMUST00000040972.1 ENSMUST00000040972.2 ENSMUST00000040972.3 NM_178918 Q3TRG8 Q8C7V3 Q8K231 UTP15_MOUSE uc007rom.1 uc007rom.2 uc007rom.3 Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75. Interacts directly with UTP4 and WDR43. Nucleus, nucleolus Note=Found predominantly at the fibrillar center. Sequence=AAH34372.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; fibrillar center nucleus nucleolus cytoplasm endoplasmic reticulum rRNA processing ribosome biogenesis positive regulation of transcription from RNA polymerase I promoter positive regulation of rRNA processing uc007rom.1 uc007rom.2 uc007rom.3 
ENSMUST00000040986.15 Rubcn ENSMUST00000040986.15 RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein, transcript variant 2 (from RefSeq NM_172615.4) ENSMUST00000040986.1 ENSMUST00000040986.10 ENSMUST00000040986.11 ENSMUST00000040986.12 ENSMUST00000040986.13 ENSMUST00000040986.14 ENSMUST00000040986.2 ENSMUST00000040986.3 ENSMUST00000040986.4 ENSMUST00000040986.5 ENSMUST00000040986.6 ENSMUST00000040986.7 ENSMUST00000040986.8 ENSMUST00000040986.9 Kiaa0226 NM_172615 Q3TAX3 Q3TD96 Q3TDF7 Q3TDU2 Q6NWW8 Q6P9T7 Q6PG18 Q80U62 Q8BMP7 Q8BY22 RUBIC_MOUSE Rubcn uc007yzl.1 uc007yzl.2 uc007yzl.3 uc007yzl.4 Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process (PubMed:19270693). Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (By similarity). Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines. Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (By similarity). Associates with PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex II (PI3KC3-C2) in which the core composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 is associated with UVRAG; in the complex interacts directly with PI3KC3 and UVRAG (PubMed:19270693). Interacts with Rab7 (RAB7A or RAB7B) (GTP-bound form); Rab7 and UVRAG compete for RUBCN binding; can interact simultaneously with Rab7 and the PI3K complex. Interacts with CYBA and CYBB; indicative for the association with the CYBA:CYBB NADPH oxidase heterodimer. Interacts with NOX4 and probably associates with the CYBA:NOX4 complex. Interacts with YWHAB and CARD9 in a competitive and stimulation-dependent manner; RUBCN exchanges interaction from YWHAB to CARD9 upon stimulation with beta-1,3-glucan (By similarity). Q80U62; P00533: EGFR; Xeno; NbExp=2; IntAct=EBI-3506572, EBI-297353; Late endosome Lysosome Early endosome Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80U62-1; Sequence=Displayed; Name=2; IsoId=Q80U62-2; Sequence=VSP_017111; Name=3; IsoId=Q80U62-3; Sequence=VSP_017110, VSP_017111; Name=4; IsoId=Q80U62-4; Sequence=VSP_039474, VSP_017110, VSP_017111; Sequence=AAH57307.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC65503.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; immune system process protein binding nucleoplasm lysosome endosome early endosome late endosome cytosol endocytosis autophagy negative regulation of autophagy intracellular membrane-bounded organelle negative regulation of phosphatidylinositol 3-kinase activity negative regulation of endocytosis negative regulation of autophagosome maturation uc007yzl.1 uc007yzl.2 uc007yzl.3 uc007yzl.4 
ENSMUST00000040987.11 Akr1d1 ENSMUST00000040987.11 aldo-keto reductase family 1, member D1 (from RefSeq NM_145364.2) AK1D1_MOUSE ENSMUST00000040987.1 ENSMUST00000040987.10 ENSMUST00000040987.2 ENSMUST00000040987.3 ENSMUST00000040987.4 ENSMUST00000040987.5 ENSMUST00000040987.6 ENSMUST00000040987.7 ENSMUST00000040987.8 ENSMUST00000040987.9 NM_145364 Q8VCX1 uc009bjg.1 uc009bjg.2 uc009bjg.3 Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). Reaction=5beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH; Xref=Rhea:RHEA:11524, ChEBI:CHEBI:15378, ChEBI:CHEBI:16074, ChEBI:CHEBI:16175, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.3; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:11526; Evidence=; Reaction=4,5beta-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH; Xref=Rhea:RHEA:14037, ChEBI:CHEBI:15378, ChEBI:CHEBI:16962, ChEBI:CHEBI:18093, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.3; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:14039; Evidence=; Reaction=cortisol + H(+) + NADPH = 5beta-dihydrocortisol + NADP(+); Xref=Rhea:RHEA:46644, ChEBI:CHEBI:732, ChEBI:CHEBI:15378, ChEBI:CHEBI:17650, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46645; Evidence=; Reaction=corticosterone + H(+) + NADPH = 5beta-dihydrocorticosterone + NADP(+); Xref=Rhea:RHEA:46664, ChEBI:CHEBI:15378, ChEBI:CHEBI:16827, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:86381; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46665; Evidence=; Reaction=7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+); Xref=Rhea:RHEA:46632, ChEBI:CHEBI:2288, ChEBI:CHEBI:15378, ChEBI:CHEBI:28477, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46633; Evidence=; Reaction=7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha- hydroxy-5beta-cholestan-3-one + NADP(+); Xref=Rhea:RHEA:46640, ChEBI:CHEBI:2290, ChEBI:CHEBI:15378, ChEBI:CHEBI:17899, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46641; Evidence=; Reaction=epitestosterone + H(+) + NADPH = 5beta-dihydroepitestosterone + NADP(+); Xref=Rhea:RHEA:46652, ChEBI:CHEBI:15378, ChEBI:CHEBI:42534, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:86377; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46653; Evidence=; Reaction=androst-4-ene-3,17-dione + H(+) + NADPH = 5beta-androstane- 3,17-dione + NADP(+); Xref=Rhea:RHEA:46656, ChEBI:CHEBI:15378, ChEBI:CHEBI:16422, ChEBI:CHEBI:16985, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46657; Evidence=; Reaction=H(+) + NADPH + progesterone = 5beta-pregnan-3,20-dione + NADP(+); Xref=Rhea:RHEA:46660, ChEBI:CHEBI:15378, ChEBI:CHEBI:17026, ChEBI:CHEBI:30154, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46661; Evidence=; Reaction=21-hydroxyprogesterone + H(+) + NADPH = 5beta- dihydrodeoxycorticosterone + NADP(+); Xref=Rhea:RHEA:46668, ChEBI:CHEBI:15378, ChEBI:CHEBI:16973, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:86384; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46669; Evidence=; Reaction=aldosterone + H(+) + NADPH = 5beta-dihydroaldosterone + NADP(+); Xref=Rhea:RHEA:46672, ChEBI:CHEBI:15378, ChEBI:CHEBI:27584, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:86389; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46673; Evidence=; Reaction=17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH = 17beta- hydroxy-5beta-androst-1-en-3-one + NADP(+); Xref=Rhea:RHEA:47076, ChEBI:CHEBI:15378, ChEBI:CHEBI:34584, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:87331; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47077; Evidence=; Reaction=17beta-hydroxyestr-4-en-3-one + H(+) + NADPH = 17beta-hydroxy- 5beta-estran-3-one + NADP(+); Xref=Rhea:RHEA:47080, ChEBI:CHEBI:7466, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:87333; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47081; Evidence=; Reaction=5beta-dihydrotestosterone + NADP(+) = H(+) + NADPH + testosterone; Xref=Rhea:RHEA:46636, ChEBI:CHEBI:2150, ChEBI:CHEBI:15378, ChEBI:CHEBI:17347, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46637; Evidence=; Reaction=androst-4-ene-3,11,17-trione + H(+) + NADPH = 17beta- hydroxyandrost-4-ene-3,11-dione + NADP(+); Xref=Rhea:RHEA:53484, ChEBI:CHEBI:2495, ChEBI:CHEBI:15378, ChEBI:CHEBI:34133, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53485; Evidence=; Subject to inhibition by high substrate concentrations. Inhibited by testosterone concentrations above 10 uM. Inhibited by the primary and secondary bile acids chenodeoxycholic acid and ursodeoxycholic acid. Cytoplasm Belongs to the aldo/keto reductase family. alditol:NADP+ 1-oxidoreductase activity cytoplasm cytosol lipid metabolic process bile acid biosynthetic process cholesterol catabolic process digestion alcohol dehydrogenase (NADP+) activity steroid metabolic process C21-steroid hormone metabolic process androgen metabolic process lipid catabolic process steroid dehydrogenase activity oxidoreductase activity bile acid catabolic process ketosteroid monooxygenase activity 3-oxo-5-beta-steroid 4-dehydrogenase activity delta4-3-oxosteroid 5beta-reductase activity oxidation-reduction process uc009bjg.1 uc009bjg.2 uc009bjg.3 
ENSMUST00000040990.7 Vwa8 ENSMUST00000040990.7 von Willebrand factor A domain containing 8, transcript variant 1 (from RefSeq NM_027906.1) ENSMUST00000040990.1 ENSMUST00000040990.2 ENSMUST00000040990.3 ENSMUST00000040990.4 ENSMUST00000040990.5 ENSMUST00000040990.6 Kiaa0564 NM_027906 Q3U4P9 Q6ZQ94 Q8CC88 Q8CDH8 Q8VCU3 VWA8_MOUSE uc007usq.1 uc007usq.2 uc007usq.3 uc007usq.4 Exhibits ATPase activity in vitro. Monomer (By similarity). Interacts with PEX7. Interacts with PEX5 in a PEX7-dependent manner (By similarity). Mitochondrion Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=VWA8a ; IsoId=Q8CC88-1; Sequence=Displayed; Name=2; Synonyms=VWA8b ; IsoId=Q8CC88-2; Sequence=VSP_034708; Name=3; IsoId=Q8CC88-3; Sequence=VSP_034707; Isoform 1 is predominantly expressed in liver, kidney, pancreas, heart, and skeletal muscle (at protein level). Up-regulated by high fat diet (at protein level). nucleotide binding ATP binding mitochondrion peroxisome biological_process ATPase activity uc007usq.1 uc007usq.2 uc007usq.3 uc007usq.4 
ENSMUST00000040992.8 Nek9 ENSMUST00000040992.8 NIMA (never in mitosis gene a)-related expressed kinase 9 (from RefSeq NM_145138.2) ENSMUST00000040992.1 ENSMUST00000040992.2 ENSMUST00000040992.3 ENSMUST00000040992.4 ENSMUST00000040992.5 ENSMUST00000040992.6 ENSMUST00000040992.7 NEK9_MOUSE NM_145138 Nek9 Nercc Q148U2 Q8K1R7 Q8R3P1 uc007ogx.1 uc007ogx.2 uc007ogx.3 Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr- 97 respectively. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated during mitosis by intramolecular autophosphorylation. Activity and autophosphorylation is activated by manganese >> magnesium ions. It is not cell-cycle regulated but activity is higher in G0-arrested cells. Homodimer; homodimerization is required to activate NEK7. Binds to Ran GTPase. Has a greater affinity for Ran-GDP over Ran-GTP. Interacts with SSRP1 and SUPT16H, the 2 subunits of the FACT complex. Interacts with DYNLL1; phosphorylation at Ser-949 strongly reduces DYNLL1 binding. Cytoplasm Nucleus Dimerizes through its coiled-coil domain. Autophosphorylated on serine and threonine residues. When complexed with FACT, exhibits markedly elevated phosphorylation on Thr- 210. During mitosis, not phosphorylated on Thr-210. Phosphorylated by CDK1 in vitro. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Sequence=AAH24926.1; Type=Erroneous initiation; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm centrosome protein phosphorylation cell cycle kinase activity phosphorylation transferase activity protein kinase binding metal ion binding cell division uc007ogx.1 uc007ogx.2 uc007ogx.3 
ENSMUST00000040999.14 Aox3 ENSMUST00000040999.14 aldehyde oxidase 3 (from RefSeq NM_023617.2) AOXC_MOUSE Aoh1 B2RSI5 ENSMUST00000040999.1 ENSMUST00000040999.10 ENSMUST00000040999.11 ENSMUST00000040999.12 ENSMUST00000040999.13 ENSMUST00000040999.2 ENSMUST00000040999.3 ENSMUST00000040999.4 ENSMUST00000040999.5 ENSMUST00000040999.6 ENSMUST00000040999.7 ENSMUST00000040999.8 ENSMUST00000040999.9 G3X982 NM_023617 Q8VI15 uc007bbm.1 uc007bbm.2 uc007bbm.3 Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. Reaction=an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2; Xref=Rhea:RHEA:16829, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067; EC=1.2.3.1; Evidence= Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 2 [2Fe-2S] clusters per subunit. ; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Evidence=; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. ; Inhibited by potassium cyanide, menadione, benzamidine, raloxifene and norharmane. Kinetic parameters: KM=2.3 uM for phthalazine KM=1.4 uM for phthalazine (at 37 degrees Celsius and pH 8) KM=2.5 uM for benzaldehyde (at 37 degrees Celsius and pH 8) KM=128.5 uM for N1-methylnicotinamide (at 37 degrees Celsius and pH 8) KM=32.3 uM for phenanthridine (at 37 degrees Celsius and pH 8) KM=13 uM for benzaldehyde (at 37 degrees Celsius and pH 7.4) KM=29 uM for butyraldehyde (at 37 degrees Celsius and pH 8) KM=173 uM for 2-OH-pyrimidine (at 37 degrees Celsius and pH 8) Note=kcat is 4 sec(-1) for phthalazine oxidation (PubMed:11562361). kcat is 130 min(-1) for benzaldehyde oxidation, 384 min(-1) for butyraldehyde oxidation and 1279 min(-1) for 2-OH-pyrimidine oxidation (PubMed:21705476). kcat is 41.1 min(-1) for phthalazine oxidation, 41.9 min(-1) for benzaldehyde oxidation, 14.7 min(-1) for N1-methylnicotinamide oxidation and 51.7 min(-1) for phenanthridine oxidation (PubMed:23019336). Homodimer. Cytoplasm Highly expressed in liver (at protein level). In liver, the expression is greater in males than females. Induced by testosterone. AOX genes evolved from a xanthine oxidoreductase ancestral precursor via a series of gene duplication and suppression/deletion events. Different animal species contain a different complement of AOX genes encoding an equivalent number of AOX isoenzymes. In mammals, the two extremes are represented by certain rodents such as mice and rats, which are endowed with 4 AOX genes, and by humans, whose genome is characterized by a single active gene (PubMed:23263164). Belongs to the xanthine dehydrogenase family. aldehyde oxidase activity xanthine dehydrogenase activity iron ion binding cytoplasm cytosol electron carrier activity xanthine catabolic process oxidoreductase activity drug metabolic process electron transport chain molybdenum ion binding protein homodimerization activity molybdopterin cofactor binding metal ion binding retinal oxidase activity flavin adenine dinucleotide binding NAD binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding oxidation-reduction process FAD binding uc007bbm.1 uc007bbm.2 uc007bbm.3 
ENSMUST00000041003.8 Tfb1m ENSMUST00000041003.8 transcription factor B1, mitochondrial (from RefSeq NM_146074.3) ENSMUST00000041003.1 ENSMUST00000041003.2 ENSMUST00000041003.3 ENSMUST00000041003.4 ENSMUST00000041003.5 ENSMUST00000041003.6 ENSMUST00000041003.7 NM_146074 Q8JZM0 TFB1M_MOUSE uc008aes.1 uc008aes.2 uc008aes.3 S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity). Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM (By similarity). Mitochondrion Ubiquitously expressed. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily. rRNA modification rRNA (adenine-N6,N6-)-dimethyltransferase activity DNA binding RNA binding mitochondrion rRNA processing methyltransferase activity rRNA methyltransferase activity transferase activity rRNA methylation methylation mitochondrial nucleoid uc008aes.1 uc008aes.2 uc008aes.3 
ENSMUST00000041005.6 Fxyd2 ENSMUST00000041005.6 FXYD domain-containing ion transport regulator 2, transcript variant b (from RefSeq NM_052823.3) ENSMUST00000041005.1 ENSMUST00000041005.2 ENSMUST00000041005.3 ENSMUST00000041005.4 ENSMUST00000041005.5 Fxyd2 NM_052823 Q6ITT1 Q6ITT1_MOUSE uc009pfu.1 uc009pfu.2 This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Multiple transcript variants have been described for this gene that are expressed in tissue-specific and developmental stage-specific patterns and encode proteins that differ at the N-terminus. [provided by RefSeq, Sep 2009]. May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non- catalytic beta subunit and an additional regulatory subunit. Membrane ; Single- pass type III membrane protein Belongs to the FXYD family. plasma membrane sodium:potassium-exchanging ATPase complex ion transport negative regulation of cell proliferation monovalent inorganic cation transport membrane integral component of membrane basolateral plasma membrane intracellular membrane-bounded organelle regulation of ion transport cellular hyperosmotic salinity response ion channel regulator activity regulation of sodium:potassium-exchanging ATPase activity negative regulation of sodium:potassium-exchanging ATPase activity uc009pfu.1 uc009pfu.2 
ENSMUST00000041007.4 Gjd4 ENSMUST00000041007.4 gap junction protein, delta 4 (from RefSeq NM_153086.6) B2RQL7 CXD4_MOUSE ENSMUST00000041007.1 ENSMUST00000041007.2 ENSMUST00000041007.3 NM_153086 Q8BSD4 Q8C6W6 Q91YD0 uc008eah.1 uc008eah.2 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Cell membrane ; Multi-pass membrane protein Cell junction, gap junction Belongs to the connexin family. Delta-type subfamily. molecular_function plasma membrane gap junction connexin complex cell communication regulation of satellite cell activation involved in skeletal muscle regeneration membrane integral component of membrane cell junction uc008eah.1 uc008eah.2 
ENSMUST00000041011.4 Gm9767 ENSMUST00000041011.4 predicted gene 9767 (from RefSeq NR_028030.2) ENSMUST00000041011.1 ENSMUST00000041011.2 ENSMUST00000041011.3 NR_028030 uc011xbw.1 uc011xbw.2 uc011xbw.1 uc011xbw.2 
ENSMUST00000041012.10 Ptcra ENSMUST00000041012.10 pre T cell antigen receptor alpha (from RefSeq NM_011195.3) ENSMUST00000041012.1 ENSMUST00000041012.2 ENSMUST00000041012.3 ENSMUST00000041012.4 ENSMUST00000041012.5 ENSMUST00000041012.6 ENSMUST00000041012.7 ENSMUST00000041012.8 ENSMUST00000041012.9 NM_011195 P0C6B2 PTCRA_MOUSE uc008cuh.1 uc008cuh.2 uc008cuh.3 The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. Isoform 1 acts to retain most TCRB intracellularly, while isoform 2 permits higher levels of cell surface TCRB expression and facilitates signaling from the CD3- TCRB complex. Interacts with RHBDD1 (By similarity). Heterodimer with TCRB; disulfide linked. This heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=pTalpha-a; IsoId=P0C6B2-1; Sequence=Displayed; Name=2; Synonyms=pTalpha-b; IsoId=P0C6B2-2; Sequence=VSP_031447; Isoform 1 is expressed at higher levels than isoform 2 in the thymus while only isoform 2 is expressed in polyclonal beta-only cells. Isoform 1 shows a predominant expression in immature thymocytes. Sequence=AAA58963.1; Type=Erroneous initiation; Evidence=; Sequence=AAI19063.1; Type=Erroneous initiation; Evidence=; Sequence=AAI20747.1; Type=Erroneous initiation; Evidence=; plasma membrane membrane integral component of membrane negative regulation of thymocyte apoptotic process uc008cuh.1 uc008cuh.2 uc008cuh.3 
ENSMUST00000041022.15 Trim46 ENSMUST00000041022.15 tripartite motif-containing 46, transcript variant 2 (from RefSeq NM_183037.2) ENSMUST00000041022.1 ENSMUST00000041022.10 ENSMUST00000041022.11 ENSMUST00000041022.12 ENSMUST00000041022.13 ENSMUST00000041022.14 ENSMUST00000041022.2 ENSMUST00000041022.3 ENSMUST00000041022.4 ENSMUST00000041022.5 ENSMUST00000041022.6 ENSMUST00000041022.7 ENSMUST00000041022.8 ENSMUST00000041022.9 NM_183037 Q60717 Q6P1I9 Q7TNM2 TRI46_MOUSE Trific uc008pyk.1 uc008pyk.2 Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon formation, the establishment of neuronal polarity and proper neuronal migration. Interacts with TUBB3 and TUBA4A. Cell projection, axon Cytoplasm, cytoskeleton Note=Microtubule-associated. Localizes to the proximal part of the axon. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TNM2-1; Sequence=Displayed; Name=2; IsoId=Q7TNM2-2; Sequence=VSP_011985, VSP_011986, VSP_011987; Expressed in the central nervous system, including pyramidal neurons and interneurons in the cortex and hippocampus and all neuronal cell types in the cerebral and cerebellar cortex, and in the peripheral nervous system, including the dorsal root ganglion neurons. Belongs to the TRIM/RBCC family. microtubule cytoskeleton organization microtubule bundle formation neuron migration cytoplasm cytoskeleton axonogenesis microtubule binding zinc ion binding microtubule cytoskeleton axon negative regulation of axon extension cell projection axon initial segment main axon metal ion binding anterograde synaptic vesicle transport protein localization to axon positive regulation of anterograde dense core granule transport regulation of cellular protein localization axon cytoplasm proximal neuron projection uc008pyk.1 uc008pyk.2 
ENSMUST00000041023.14 Ipo9 ENSMUST00000041023.14 importin 9, transcript variant 1 (from RefSeq NM_153774.1) E9QKZ2 E9QKZ2_MOUSE ENSMUST00000041023.1 ENSMUST00000041023.10 ENSMUST00000041023.11 ENSMUST00000041023.12 ENSMUST00000041023.13 ENSMUST00000041023.2 ENSMUST00000041023.3 ENSMUST00000041023.4 ENSMUST00000041023.5 ENSMUST00000041023.6 ENSMUST00000041023.7 ENSMUST00000041023.8 ENSMUST00000041023.9 Ipo9 NM_153774 uc007cte.1 uc007cte.2 uc007cte.3 Cytoplasm nucleus cytoplasm protein import into nucleus intracellular protein transport Ran GTPase binding nuclear import signal receptor activity uc007cte.1 uc007cte.2 uc007cte.3 
ENSMUST00000041024.15 Afg1l ENSMUST00000041024.15 AFG1 like ATPase, transcript variant 1 (from RefSeq NM_145743.2) AFG1L_MOUSE Afg1l ENSMUST00000041024.1 ENSMUST00000041024.10 ENSMUST00000041024.11 ENSMUST00000041024.12 ENSMUST00000041024.13 ENSMUST00000041024.14 ENSMUST00000041024.2 ENSMUST00000041024.3 ENSMUST00000041024.4 ENSMUST00000041024.5 ENSMUST00000041024.6 ENSMUST00000041024.7 ENSMUST00000041024.8 ENSMUST00000041024.9 Lace1 NM_145743 Q3V384 Q5EBH5 Q8K1E9 uc007eyq.1 uc007eyq.2 Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress. Found in several complexes of 140-500 kDa. Interacts with YME1L1. Interacts with COX4I1. Interacts with COX5A. Interacts with TP53; mediates mitochondrial translocation of TP53 in response to genotoxic stress such as mitomycin C treatment. Mitochondrion membrane Highly expressed in heart, kidney, and lactating breast. Present at reduced levels in virgin, pregnant, and involuting breast. Expression is elevated during lactation. Belongs to the AFG1 ATPase family. nucleotide binding ATP binding cytoplasm mitochondrion mitochondrial electron transport, cytochrome c to oxygen mitochondrion organization membrane hydrolase activity ATPase activity mitochondrial membrane mitochondrial protein catabolic process uc007eyq.1 uc007eyq.2 
ENSMUST00000041029.6 Smad6 ENSMUST00000041029.6 SMAD family member 6 (from RefSeq NM_008542.3) ENSMUST00000041029.1 ENSMUST00000041029.2 ENSMUST00000041029.3 ENSMUST00000041029.4 ENSMUST00000041029.5 Madh6 Madh7 Msmad6 NM_008542 O35182 Q9CW62 SMAD6_MOUSE uc009qbk.1 uc009qbk.2 uc009qbk.3 Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta (By similarity). Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of pro-inflammatory genes (PubMed:16951688). Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions (By similarity). Interacts with NEDD4L. Interacts with WWP1. Interacts with STAMBP and PRKX (By similarity). Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, including ACVR1B, BMPR1B and TGFBR1. In response to BMP2 treatment, interacts with SMAD1; this interaction may inhibit SMAD1-binding to SMAD4. Interacts with HOXC8 and HOXC9 (By similarity). Interacts with PELI1; this interaction interferes with PELI1 complex formation with TRAF6, IRAK1, IRAK4 and MYD88 in response to IL1B and hence negatively regulates IL1R-TLR signaling. Interacts with TSC22D1/TSC-22 (By similarity). O35182; O35625: Axin1; NbExp=2; IntAct=EBI-4321242, EBI-2365912; O35182; P36898: Bmpr1b; NbExp=2; IntAct=EBI-4321242, EBI-7107883; O35182; Q9JIF0: Prmt1; NbExp=3; IntAct=EBI-4321242, EBI-519055; O35182; Q9C0C9: UBE2O; Xeno; NbExp=4; IntAct=EBI-4321242, EBI-2339946; Nucleus Ubiquitous in various organs, with higher levels in lung. By TGF-beta and BMP4. Monoubiquitinated at Lys-174 by the E2/E3 hybrid ubiquitin-protein ligase UBE2O, leading to reduced binding affinity for the activated BMP type I receptor ACVR1/ALK2, thereby enhancing BMP7 and regulating adipocyte differentiation (By similarity). Ubiquitinated by WWP1 (PubMed:15221015). Ubiquitinated by ARK2C, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling (PubMed:23610558). Arginine methylation by PRMT1, which is recruited by BMPR2, initiates BMP-Induced signaling and induces dissociation from the BMPR1B receptor at the cell surface leading to derepress downstream Smad1/Smad5 signaling. Phosphorylated by BMP type 1 receptor kinase and by PRKX. Belongs to the dwarfin/SMAD family. RNA polymerase II core promoter proximal region sequence-specific DNA binding ureteric bud development outflow tract septum morphogenesis heart valve development aortic valve morphogenesis mitral valve morphogenesis pulmonary valve morphogenesis ventricular septum development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex Golgi apparatus cytosol regulation of transcription, DNA-templated immune response transforming growth factor beta receptor signaling pathway zygotic specification of dorsal/ventral axis negative regulation of cell proliferation negative regulation of SMAD protein complex assembly nuclear body negative regulation of ossification BMP signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity cell-substrate adhesion ubiquitin protein ligase binding response to lipopolysaccharide macromolecular complex response to laminar fluid shear stress type I transforming growth factor beta receptor binding aorta development identical protein binding negative regulation of apoptotic process response to estrogen transcription regulatory region DNA binding fat cell differentiation negative regulation of osteoblast differentiation positive regulation of vasoconstriction metal ion binding negative regulation of pathway-restricted SMAD protein phosphorylation cardiac vascular smooth muscle cell development coronary vasculature development coronary vasculature morphogenesis co-SMAD binding I-SMAD binding R-SMAD binding type I activin receptor binding positive regulation of pri-miRNA transcription from RNA polymerase II promoter uc009qbk.1 uc009qbk.2 uc009qbk.3 
ENSMUST00000041045.14 H2az1 ENSMUST00000041045.14 H2A.Z variant histone 1, transcript variant 1 (from RefSeq NM_016750.3) B2RXZ3 ENSMUST00000041045.1 ENSMUST00000041045.10 ENSMUST00000041045.11 ENSMUST00000041045.12 ENSMUST00000041045.13 ENSMUST00000041045.2 ENSMUST00000041045.3 ENSMUST00000041045.4 ENSMUST00000041045.5 ENSMUST00000041045.6 ENSMUST00000041045.7 ENSMUST00000041045.8 ENSMUST00000041045.9 H2AZ_MOUSE H2afz H2az H2az1 NM_016750 P0C0S6 P17317 Q3UA55 Q3UK43 Q68FD2 uc008rmo.1 uc008rmo.2 uc008rmo.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Essential for early development. Interacts (via M6 cassette) with ANP32E; leading to removal of H2A.Z/H2AZ1 from the nucleosome (By similarity). The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ1 forms a heterodimer with H2B (By similarity). Interacts with INCENP (PubMed:12660166). Interacts with VPS72 (via N-terminal domain); the interaction is enhanced by VPS72 phosphorylation which is promoted by ZNHIT1 (PubMed:30842416). Interacts with PWWP2A (By similarity). Interacts with FH (when phosphorylated by PRKDC) (By similarity). Interacts with ZNHIT1; the interaction results in recruitment of H2AZ1 to the MYOG promoter region which is required for muscle-specific gene expression (By similarity). Nucleus Chromosome Note=Enriched in constitutive heterochromatin (PubMed:12660166, PubMed:15195148). Absent from facultative heterochromatin of the inactive X chromosome (PubMed:12660166). Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression. Acetylated on Lys-5, Lys-8, Lys-12 and Lys-14 by KAT2A; KAT2A is recruited by the XPC complex in absence of DNA damage (By similarity). Acetylated on Lys-5, Lys-8 and Lys-12 during interphase; acetylation disappears at mitosis (PubMed:16204459, PubMed:7217105). Acetylation by the NuA4 histone acetyltransferase complex is required for hematopoietic stem cell maintenance (PubMed:32542325). Not phosphorylated. Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Down-regulation of H2az1 by RNA interference leads to death at early embryonic stages. Belongs to the histone H2A family. nucleosome nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding DNA binding nucleus chromosome nuclear euchromatin nuclear heterochromatin chromatin organization multicellular organism development chromatin DNA binding nucleosomal DNA binding cellular response to insulin stimulus positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity cellular response to estradiol stimulus Barr body uc008rmo.1 uc008rmo.2 uc008rmo.3 
ENSMUST00000041047.4 Lnpep ENSMUST00000041047.4 leucyl/cystinyl aminopeptidase (from RefSeq NM_172827.3) ENSMUST00000041047.1 ENSMUST00000041047.2 ENSMUST00000041047.3 LCAP_MOUSE NM_172827 Q8C129 uc008apk.1 uc008apk.2 uc008apk.3 Release of an N-terminal amino acid, cleave before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain (By similarity). Reaction=Release of an N-terminal amino acid, Cys-|-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.; EC=3.4.11.3; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Homodimer. Binds tankyrases 1 and 2 (By similarity). Cell membrane ; Single-pass type II membrane protein Endomembrane system ; Single-pass type II membrane protein Note=Localized mainly in intracellular vesicles together with GLUT4. Relocalizes to the plasma membrane in response to insulin. The dileucine internalization motif and/or the interaction with tankyrases may be involved in intracellular sequestration (By similarity). Belongs to the peptidase M1 family. aminopeptidase activity protein binding cytoplasm plasma membrane integral component of plasma membrane proteolysis peptidase activity metallopeptidase activity zinc ion binding endomembrane system membrane integral component of membrane hydrolase activity protein catabolic process cytoplasmic vesicle membrane peptide binding peptide catabolic process metal ion binding perinuclear region of cytoplasm SMAD protein signal transduction metalloaminopeptidase activity uc008apk.1 uc008apk.2 uc008apk.3 
ENSMUST00000041048.6 Orai2 ENSMUST00000041048.6 ORAI calcium release-activated calcium modulator 2 (from RefSeq NM_178751.3) ENSMUST00000041048.1 ENSMUST00000041048.2 ENSMUST00000041048.3 ENSMUST00000041048.4 ENSMUST00000041048.5 NM_178751 ORAI2_MOUSE Q8BH10 Q8C953 Tmem142b uc009aad.1 uc009aad.2 uc009aad.3 uc009aad.4 uc009aad.5 Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1. Interacts with CRACR2A/EFCAB4B. Membrane ; Multi-pass membrane protein Belongs to the Orai family. Sequence=BAC31410.1; Type=Frameshift; Evidence=; store-operated calcium entry store-operated calcium channel activity membrane integral component of membrane growth cone calcium ion transmembrane transport uc009aad.1 uc009aad.2 uc009aad.3 uc009aad.4 uc009aad.5 
ENSMUST00000041052.5 H1f6 ENSMUST00000041052.5 H1.6 linker histone, cluster member (from RefSeq NM_010377.3) ENSMUST00000041052.1 ENSMUST00000041052.2 ENSMUST00000041052.3 ENSMUST00000041052.4 H1f6 Hist1h1t I7HFT9 I7HFT9_MOUSE NM_010377 uc007pun.1 uc007pun.2 uc007pun.3 uc007pun.4 Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Nucleus Belongs to the histone H1/H5 family. nucleosome DNA binding nucleus chromosome nucleosome assembly spermatogenesis uc007pun.1 uc007pun.2 uc007pun.3 uc007pun.4 
ENSMUST00000041053.11 Acaa2 ENSMUST00000041053.11 acetyl-CoA acyltransferase 2 (from RefSeq NM_177470.3) ENSMUST00000041053.1 ENSMUST00000041053.10 ENSMUST00000041053.2 ENSMUST00000041053.3 ENSMUST00000041053.4 ENSMUST00000041053.5 ENSMUST00000041053.6 ENSMUST00000041053.7 ENSMUST00000041053.8 ENSMUST00000041053.9 NM_177470 Q3TIT9 Q8BWT1 Q8JZR8 THIM_MOUSE uc008fpt.1 uc008fpt.2 uc008fpt.3 uc008fpt.4 In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta- oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activity on various fatty acyl-CoAs (By similarity). Thereby, could be responsible for the production of acetate in a side reaction to beta- oxidation (By similarity). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (By similarity). Reaction=acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA; Xref=Rhea:RHEA:21564, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58342, ChEBI:CHEBI:90726; EC=2.3.1.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21565; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21566; Evidence=; Reaction=2 acetyl-CoA = acetoacetyl-CoA + CoA; Xref=Rhea:RHEA:21036, ChEBI:CHEBI:57286, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21037; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21038; Evidence=; Reaction=acetyl-CoA + H2O = acetate + CoA + H(+); Xref=Rhea:RHEA:20289, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=3.1.2.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20290; Evidence=; Reaction=H2O + propanoyl-CoA = CoA + H(+) + propanoate; Xref=Rhea:RHEA:40103, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17272, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40104; Evidence=; Reaction=butanoyl-CoA + H2O = butanoate + CoA + H(+); Xref=Rhea:RHEA:40111, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40112; Evidence=; Reaction=H2O + hexanoyl-CoA = CoA + H(+) + hexanoate; Xref=Rhea:RHEA:40115, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57287, ChEBI:CHEBI:62620; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40116; Evidence=; Reaction=H2O + octanoyl-CoA = CoA + H(+) + octanoate; Xref=Rhea:RHEA:30143, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30144; Evidence=; Reaction=decanoyl-CoA + H2O = CoA + decanoate + H(+); Xref=Rhea:RHEA:40059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40060; Evidence=; Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence=; Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=; Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence=; Lipid metabolism; fatty acid beta-oxidation. Homotetramer. Interacts with BNIP3. Mitochondrion Belongs to the thiolase-like superfamily. Thiolase family. catalytic activity acetyl-CoA C-acetyltransferase activity acetyl-CoA hydrolase activity acetyl-CoA C-acyltransferase activity mitochondrion mitochondrial inner membrane mitochondrial matrix acetyl-CoA metabolic process lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation palmitoyl-CoA hydrolase activity transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups hydrolase activity acyl-CoA hydrolase activity cellular response to hypoxia negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway negative regulation of mitochondrial membrane permeability involved in apoptotic process uc008fpt.1 uc008fpt.2 uc008fpt.3 uc008fpt.4 
ENSMUST00000041055.9 Atg2b ENSMUST00000041055.9 autophagy related 2B, transcript variant 1 (from RefSeq NM_029654.5) A0PJL7 ATG2B_MOUSE Atg2b ENSMUST00000041055.1 ENSMUST00000041055.2 ENSMUST00000041055.3 ENSMUST00000041055.4 ENSMUST00000041055.5 ENSMUST00000041055.6 ENSMUST00000041055.7 ENSMUST00000041055.8 NM_029654 Q80XK6 Q8BIQ4 Q8BIV0 Q8R1H5 Q9CWK6 uc007oyp.1 uc007oyp.2 uc007oyp.3 uc007oyp.4 uc007oyp.5 Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (By similarity). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)- containing membranes (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2- diacyl-sn-glycero-3-phosphoethanolamine(out); Xref=Rhea:RHEA:38895, ChEBI:CHEBI:64612; Evidence=; Interacts with WDR45/WIPI4. Q80XK6; O07177: mak; Xeno; NbExp=3; IntAct=EBI-11566520, EBI-25767633; Q80XK6; O07422: Rv0178; Xeno; NbExp=3; IntAct=EBI-11566520, EBI-25767563; Q80XK6; I6Y946: Rv0925c; Xeno; NbExp=3; IntAct=EBI-11566520, EBI-25767727; Q80XK6; P9WIT1: Rv2280; Xeno; NbExp=3; IntAct=EBI-11566520, EBI-25767539; Preautophagosomal structure membrane ; Peripheral membrane protein Lipid droplet Endoplasmic reticulum membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80XK6-2; Sequence=Displayed; Name=2; IsoId=Q80XK6-4; Sequence=VSP_035038; Name=3; IsoId=Q80XK6-5; Sequence=VSP_035039; The chorein N-terminal domain mediates lipid transfer activity. Belongs to the ATG2 family. Sequence=AAH46427.3; Type=Erroneous initiation; Evidence=; Sequence=AK085790; Type=Frameshift; Evidence=; Sequence=BAC28052.1; Type=Erroneous initiation; Evidence=; autophagosome assembly pre-autophagosomal structure mitophagy molecular_function nucleoplasm lipid particle autophagy membrane extrinsic component of membrane pre-autophagosomal structure membrane uc007oyp.1 uc007oyp.2 uc007oyp.3 uc007oyp.4 uc007oyp.5 
ENSMUST00000041059.12 Trpc4ap ENSMUST00000041059.12 transient receptor potential cation channel, subfamily C, member 4 associated protein, transcript variant 1 (from RefSeq NM_001163452.1) ENSMUST00000041059.1 ENSMUST00000041059.10 ENSMUST00000041059.11 ENSMUST00000041059.2 ENSMUST00000041059.3 ENSMUST00000041059.4 ENSMUST00000041059.5 ENSMUST00000041059.6 ENSMUST00000041059.7 ENSMUST00000041059.8 ENSMUST00000041059.9 NM_001163452 Q920J6 Q99L03 Q9JLV2 TP4AP_MOUSE Trpc4ap Trrp4ap uc008nlc.1 uc008nlc.2 uc008nlc.3 uc008nlc.4 Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation (By similarity). Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (PubMed:14585990). Involved in JNK activation via its interaction with TRAF2 (PubMed:16876162). Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1 (PubMed:20458742). Protein modification; protein ubiquitination. Component of the DCX(TRPC4AP) E3 ubiquitin ligase complex, at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1 (By similarity). Interacts with MYC (By similarity). Constitutively associated with TNFRSF1A (PubMed:14585990). Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG (PubMed:16876162, PubMed:14585990). Interacts with TRPC1, TRPC4 and TRPC5 (PubMed:20458742). Cytoplasm, perinuclear region Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JLV2-1; Sequence=Displayed; Name=2; IsoId=Q9JLV2-2; Sequence=VSP_003983; Widely expressed, with high levels in heart, liver and testis. Phosphorylated by GSK3B; phosphorylation is required for ubiquitination. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin- protein ligase containing SKP2, leading to its degradation. Phosphorylation by GSK3B is required for ubiquitination. Sequence=AAL08422.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ubiquitin-dependent protein catabolic process protein ubiquitination phosphatase binding Cul4A-RING E3 ubiquitin ligase complex hair follicle maturation uc008nlc.1 uc008nlc.2 uc008nlc.3 uc008nlc.4 
ENSMUST00000041065.14 Myo1d ENSMUST00000041065.14 myosin ID (from RefSeq NM_177390.3) ENSMUST00000041065.1 ENSMUST00000041065.10 ENSMUST00000041065.11 ENSMUST00000041065.12 ENSMUST00000041065.13 ENSMUST00000041065.2 ENSMUST00000041065.3 ENSMUST00000041065.4 ENSMUST00000041065.5 ENSMUST00000041065.6 ENSMUST00000041065.7 ENSMUST00000041065.8 ENSMUST00000041065.9 MYO1D_MOUSE Myo1d NM_177390 Q5SSK7 Q5SYD0 Q8BWY5 uc007kmh.1 uc007kmh.2 uc007kmh.3 Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). Interacts (via the two IQ motifs) with calmodulin. Binds an additional calmodulin chain via a third, C-terminal region. Interacts with F-actin. Cytoplasm Perikaryon Cell projection, dendrite Early endosome Cytoplasm, cell cortex Basolateral cell membrane Note=Colocalizes with the actin cytoskeleton in the cell cortex close to the basolateral cell membrane (PubMed:20089841). Colocalizes with the actin cytoskeleton in the cell cortex close to the apical cell membrane (PubMed:20089841). Colocalizes with cytoplasmic puncta that are reminiscent of transport vesicles (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SYD0-1; Sequence=Displayed; Name=2 ; IsoId=Q5SYD0-2; Sequence=VSP_051938, VSP_051939; Detected in enterocytes at the intestinal brush border membrane. Detected at the tip of intestinal microvilli (at protein level). Binds a calmodulin chain via each of the two IQ domains. IQ domain 1 mediates interaction with calmodulin both in the presence and in the absence of Ca(2+). IQ domain 2 mediates interaction with calmodulin in the presence of Ca(2+). The TH1 domain is required for activity in complementing zebrafish defects in Kupffer's vesicle lumen size. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1). Contrary to the situation in zebrafish, xenopus and drosophila, mammalian MYO1D defects have no effects on left-right body asymmetry. Sequence=BAC33719.1; Type=Frameshift; Evidence=; microfilament motor activity nucleotide binding motor activity actin binding protein binding calmodulin binding ATP binding cytoplasm endosome early endosome smooth endoplasmic reticulum cytosol plasma membrane brush border cell cortex negative regulation of phosphatase activity protein transport membrane basolateral plasma membrane myosin complex protein domain specific binding axon dendrite axolemma actin-dependent ATPase activity forebrain development cytoplasmic vesicle cell projection neuron projection neuronal cell body perikaryon myelin sheath plasma membrane raft calcium-dependent protein binding actin filament binding cellular localization early endosome to recycling endosome transport apical dendrite uc007kmh.1 uc007kmh.2 uc007kmh.3 
ENSMUST00000041080.7 Fzd8 ENSMUST00000041080.7 frizzled class receptor 8 (from RefSeq NM_008058.2) A2RTK9 ENSMUST00000041080.1 ENSMUST00000041080.2 ENSMUST00000041080.3 ENSMUST00000041080.4 ENSMUST00000041080.5 ENSMUST00000041080.6 FZD8_MOUSE NM_008058 Q61091 uc008eag.1 uc008eag.2 uc008eag.3 uc008eag.4 Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (By similarity). The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by DKK1 (By similarity). Interacts (via the PDZ-binding motif) with GPOC (via its PDZ domain). Interacts with RSPO1 and RSPO3. Interacts with glypican GPC3 (By similarity). Q61091; Q8BH60: Gopc; NbExp=3; IntAct=EBI-6171689, EBI-296357; Q61091; P47879: Igfbp4; NbExp=3; IntAct=EBI-6171689, EBI-15706768; Q61091; P27467: Wnt3a; NbExp=7; IntAct=EBI-6171689, EBI-2899665; Q61091; O75581: LRP6; Xeno; NbExp=4; IntAct=EBI-6171689, EBI-910915; Q61091; P56703: WNT3; Xeno; NbExp=2; IntAct=EBI-6171689, EBI-3644922; Q61091; P28026: wnt8; Xeno; NbExp=3; IntAct=EBI-6171689, EBI-6257743; Membrane; Multi-pass membrane protein. Golgi apparatus. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with GOPC at the Golgi apparatus. Expressed in chondrocytes. Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. The FZ domain is involved in binding with Wnt ligands. Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. Belongs to the G-protein coupled receptor Fz/Smo family. angiogenesis positive regulation of protein phosphorylation transmembrane signaling receptor activity G-protein coupled receptor activity receptor binding protein binding extracellular region Golgi apparatus plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway multicellular organism development membrane integral component of membrane Wnt signaling pathway Wnt-protein binding PDZ domain binding ubiquitin protein ligase binding T cell differentiation in thymus non-canonical Wnt signaling pathway Wnt-activated receptor activity positive regulation of JUN kinase activity canonical Wnt signaling pathway Wnt-Frizzled-LRP5/6 complex uc008eag.1 uc008eag.2 uc008eag.3 uc008eag.4 
ENSMUST00000041093.6 Creb3l2 ENSMUST00000041093.6 cAMP responsive element binding protein 3-like 2 (from RefSeq NM_178661.4) B2RRL0 Bbf2h7 CR3L2_MOUSE ENSMUST00000041093.1 ENSMUST00000041093.2 ENSMUST00000041093.3 ENSMUST00000041093.4 ENSMUST00000041093.5 NM_178661 Q8BH52 Q8CB61 Q8CBN2 uc009bje.1 uc009bje.2 uc009bje.3 uc009bje.4 Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (PubMed:19767744). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). Binds DNA as a dimer. Endoplasmic reticulum membrane ; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus Note=Upon ER stress, translocated into the nucleus. Widely expressed, including in lung, bladder, ovary, testis and spleen (PubMed:17178827). Highly expressed in chondrocytes (PubMed:19767744). Up-regulated by ER stress at the transcript and protein levels, the increase at the protein level is much higher than at the transcript level. This induction is accompanied by increased proteolytic cleavage that releases the N-terminal transcription factor domain. Up-regulated in brain areas undergoing ischemic injury, in neurons, but not astrocytes. Up-regulated by SOX9 during chondrocyte differentiation, possibly through SOX9-induced mild ER stress (PubMed:19767744). Upon ER stress, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2). N-glycosylated. Ubiquitinated by HRD1/SYVN1; undergoes 'Lys-48'-linked ubiquitination, followed by rapid proteasomal degradation under normal conditions. Upon ER stress, SYVN1 E3 ubiquitin-protein ligase dissociates from its substrate, ubiquitination does not occur and CREB3L2 is stabilized. Mutant mice are born at the expected Mendelian rate, but die by suffocation shortly after birth because of an immature chest cavity. They exhibit severe chondrodysplasia. The cartilage shows a lack of typical columnar structure in the proliferating zone and a decrease in the size of the hypertrophic zone, resulting in a significant reduction of extracellular matrix proteins. Proliferating chondrocytes show abnormally expanded ER, containing aggregated type II collagen and cartilage oligomeric matrix protein (COMP). Displays significant decrease in Sec23a levels. Belongs to the bZIP family. ATF subfamily. Golgi membrane chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding chondrocyte differentiation DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol regulation of transcription, DNA-templated ER to Golgi vesicle-mediated transport response to unfolded protein multicellular organism development response to wounding positive regulation of gene expression positive regulation of neuron projection development membrane integral component of membrane endoplasmic reticulum unfolded protein response response to endoplasmic reticulum stress cAMP response element binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cartilage development perinuclear endoplasmic reticulum uc009bje.1 uc009bje.2 uc009bje.3 uc009bje.4 
ENSMUST00000041095.14 Aoc2 ENSMUST00000041095.14 amine oxidase copper containing 2 (from RefSeq NM_178932.1) A2A4J0 AOC2_MOUSE ENSMUST00000041095.1 ENSMUST00000041095.10 ENSMUST00000041095.11 ENSMUST00000041095.12 ENSMUST00000041095.13 ENSMUST00000041095.2 ENSMUST00000041095.3 ENSMUST00000041095.4 ENSMUST00000041095.5 ENSMUST00000041095.6 ENSMUST00000041095.7 ENSMUST00000041095.8 ENSMUST00000041095.9 NM_178932 Q80WP3 Q812C9 uc007loo.1 uc007loo.2 uc007loo.3 uc007loo.4 Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina (By similarity). Reaction=an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:16153, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478, ChEBI:CHEBI:28938, ChEBI:CHEBI:58001; EC=1.4.3.21; Evidence=; Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Note=Binds 1 copper ion per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 calcium ions per subunit. ; Name=L-topaquinone; Xref=ChEBI:CHEBI:79027; Evidence=; Note=Contains 1 topaquinone per subunit. ; Homodimer; disulfide-linked (By similarity). Forms a heterodimer with AOC3 (By similarity). Significantly much highly expressed in retina. Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. Belongs to the copper/topaquinone oxidase family. copper ion binding plasma membrane catecholamine metabolic process visual perception primary amine oxidase activity amine metabolic process oxidoreductase activity metal ion binding quinone binding tryptamine:oxygen oxidoreductase (deaminating) activity aminoacetone:oxygen oxidoreductase(deaminating) activity aliphatic-amine oxidase activity phenethylamine:oxygen oxidoreductase (deaminating) activity oxidation-reduction process uc007loo.1 uc007loo.2 uc007loo.3 uc007loo.4 
ENSMUST00000041096.4 Pcsk1n ENSMUST00000041096.4 proprotein convertase subtilisin/kexin type 1 inhibitor (from RefSeq NM_013892.3) ENSMUST00000041096.1 ENSMUST00000041096.2 ENSMUST00000041096.3 NM_013892 PCS1N_MOUSE Q91W26 Q9QXV0 uc009snf.1 uc009snf.2 uc009snf.3 May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. [Big LEN]: Endogenous ligand for GPR171 (PubMed:24043826). Neuropeptide involved in the regulation of feeding (PubMed:24043826). [PEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. Interacts via the C-terminal inhibitory domain with PCSK1 66 kDa form. Secreted lgi apparatus, trans-Golgi network Expressed in brain (mostly hypothalamus and pituitary) and gut. Expressed in trigeminal ganglia and neuroendocrine cell lines. [PEN]: Expressed in pancreas, spinal cord and brain (most abundant in striatum, hippocampus, pons and medulla, and cortex) (at protein level). Broadly expressed from 9 dpc to 11 dpc, with some enrichment in neural tube-derived tissues. By 15 dpc, the expression is largely restricted to neuroendocrine tissues. ProSAAS(1-180) increases secretion of enzymatically inactive PCSK1. The C-terminal inhibitory domain is involved in inhibition of PCSK1. It corresponds to the probable processing intermediate Big PEN- LEN, binds to PCSK1 in vitro and contains the hexapeptide L-L-R-V-K-R, which, as a synthetic peptide, is sufficient for PCSK1 inhibition. [Big LEN]: The four C-terminal amino acids of Big LEN are sufficient to bind and activate GPR171. Proteolytically cleaved in the Golgi. Little SAAS, PEN, PEN-20 and Big LEN are the major processed peptides in proSAAS-overexpressing AtT- 20 pituitary corticotropic cell line. response to dietary excess endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity extracellular region extracellular space Golgi apparatus trans-Golgi network neuropeptide signaling pathway response to cold negative regulation of endopeptidase activity peptide hormone processing secretory granule uc009snf.1 uc009snf.2 uc009snf.3 
ENSMUST00000041097.13 Ppp2r2d ENSMUST00000041097.13 protein phosphatase 2, regulatory subunit B, delta, transcript variant 1 (from RefSeq NM_026391.2) 2ABD_MOUSE D7Ertd753e ENSMUST00000041097.1 ENSMUST00000041097.10 ENSMUST00000041097.11 ENSMUST00000041097.12 ENSMUST00000041097.2 ENSMUST00000041097.3 ENSMUST00000041097.4 ENSMUST00000041097.5 ENSMUST00000041097.6 ENSMUST00000041097.7 ENSMUST00000041097.8 ENSMUST00000041097.9 Kiaa1541 NM_026391 Q6ZPN5 Q925E7 uc009kfe.1 uc009kfe.2 uc009kfe.3 uc009kfe.4 B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at 'Ser-67') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By similarity). Interacts with IER5 (By similarity). Cytoplasm Belongs to the phosphatase 2A regulatory subunit B family. Sequence=BAC98196.2; Type=Erroneous initiation; Evidence=; protein phosphatase type 2A complex mitotic cell cycle cytoplasm cytosol cell cycle exit from mitosis protein phosphatase regulator activity regulation of phosphoprotein phosphatase activity cell division peptidyl-serine dephosphorylation protein serine/threonine phosphatase activity uc009kfe.1 uc009kfe.2 uc009kfe.3 uc009kfe.4 
ENSMUST00000041099.5 Neurod1 ENSMUST00000041099.5 neurogenic differentiation 1 (from RefSeq NM_010894.3) ENSMUST00000041099.1 ENSMUST00000041099.2 ENSMUST00000041099.3 ENSMUST00000041099.4 NDF1_MOUSE NM_010894 Neurod Q545N9 Q60867 Q60897 uc008kgt.1 uc008kgt.2 uc008kgt.3 Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. Efficient DNA-binding requires dimerization with another bHLH protein (PubMed:12810726, PubMed:18069799). Heterodimer with TCF3/E47; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E- box element (PubMed:18069799, PubMed:23395635). Interacts with EP300; the interaction is inhibited by NR0B2 (PubMed:9512516). Interacts with RREB1 (By similarity). Interacts with ATOH8 (PubMed:18560595). Q60867; O95273: CCNDBP1; Xeno; NbExp=4; IntAct=EBI-309315, EBI-748961; Cytoplasm Nucleus Note=In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation. Colocalizes with NR0B2 in the nucleus (By similarity). Expressed in pancreatic beta cells, pulmonary neuroendocrine cells and retinal interneurons amacrine cells (at protein level). Expressed in endocrine cells of the pancreas. Expressed in the inner layer of cerebellar external granular layer (EGL). Expressed in the Ammon's horn (AH), which includes the CA1-CA3 pyramidal layer and in granule cells of the dentate gyrus (DG). Expressed in photoreceptors of the outer nuclear layer (ONL), in a subset of cells in the lower half of the inner nuclear layer (INL), and in a subset of cells in the ganglion cell layer (GCL) of the retina. Expressed in cholinergic and AII amacrine cell types. Expressed in differentiating neurons of both the central and peripheral nervous systems. Expressed in glucagon- and ghrelin-producing cells of the pancreas at 14.5 dpc. Expressed in each of the hormone-producing cells population of the pancreas, except somatostatin-producing cells at 16.5 dpc (at protein level). Expressed during embryonic development. Expressed in the earliest islet precursor cells of the pancreas at 9.5 dpc. Expressed in neuronal cells in the inner ear between 9.5 and 12.5 dpc. Expressed within the otic epithelium and among the delaminating cells migrating away from the ear to form sensory neurons at 10.5 dpc. Expressed in the upper blade of the nascent dentate gyrus at 16.5 dpc. Up-regulated by NKX2-2 and NEUROG3. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-336; which promotes dendritic growth (By similarity). Phosphorylated by MAPK1; phosphorylation regulates heterodimerization and DNA-binding activities. Phosphorylation on Ser-266 and Ser-274 increases transactivation on the insulin promoter in glucose-stimulated insulinoma cells. Mice are deaf and die shortly after birth due to neonatal diabetes that results from developmental and functional defects of the pancreatic endocrine cells. Show a loss of enteroendocrine cells in the small intestine, airway and alveolar epithelial cells in the lung, granular neuronal cells in the cerebellum, hippocampal dentate gyrus and sensory neurons in the inner ear due to extensive cell death that occurs during the early stages of differentiation. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding pancreatic A cell fate commitment pancreatic PP cell fate commitment DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated nucleocytoplasmic transport nitric oxide mediated signal transduction multicellular organism development nervous system development transcription factor binding response to glucose anterior/posterior pattern specification dentate gyrus development cerebellum development signal transduction involved in regulation of gene expression insulin secretion cell differentiation hindbrain development endocrine pancreas development amacrine cell differentiation enteroendocrine cell differentiation response to drug glucose homeostasis camera-type eye development positive regulation of apoptotic process sequence-specific DNA binding cell fate commitment positive regulation of cell differentiation regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JAK-STAT cascade protein heterodimerization activity protein dimerization activity embryonic organ morphogenesis neuron development inner ear development positive regulation of sequence-specific DNA binding transcription factor activity regulation of intestinal epithelial structure maintenance E-box binding regulation of cell cycle arrest cellular response to glucose stimulus RNA polymerase II transcription factor complex negative regulation of type B pancreatic cell apoptotic process positive regulation of transcription regulatory region DNA binding uc008kgt.1 uc008kgt.2 uc008kgt.3 
ENSMUST00000041100.4 Alkbh4 ENSMUST00000041100.4 alkB homolog 4, lysine demethylase, transcript variant 6 (from RefSeq NM_001359417.1) ALKB4_MOUSE Alkbh4 ENSMUST00000041100.1 ENSMUST00000041100.2 ENSMUST00000041100.3 NM_001359417 Q8R1Y9 Q9D8F1 uc009aab.1 uc009aab.2 uc009aab.3 uc009aab.4 Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (By similarity). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (PubMed:30982744). Reaction=2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:49524, Rhea:RHEA-COMP:12418, Rhea:RHEA-COMP:12419, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=1.14.11.51; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49525; Evidence=; Reaction=2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + L-lysyl-[protein] + succinate; Xref=Rhea:RHEA:60924, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13053, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60925; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Interacts with ZFHX3, MLLT3, MLLT1, HSF4, EP300, TES, EIF3C, MTMR6 and PSMA6. Cytoplasm Nucleus Nucleus, nucleolus Midbody Note=Associates with the contractile ring and midbody. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D8F1-1; Sequence=Displayed; Name=2; IsoId=Q9D8F1-2; Sequence=VSP_019129; Embryonic lethality (PubMed:23673617). Conditional deletion in developing juvenile mice leads to spermatogenic defects (PubMed:25153837). Belongs to the alkB family. actin binding nucleus cytoplasm protein demethylation oxidoreductase activity midbody actomyosin structure organization demethylase activity cleavage furrow ingression metal ion binding dioxygenase activity oxidation-reduction process contractile ring demethylation oxidative demethylation oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors uc009aab.1 uc009aab.2 uc009aab.3 uc009aab.4 
ENSMUST00000041110.12 Ttc7 ENSMUST00000041110.12 tetratricopeptide repeat domain 7, transcript variant 2 (from RefSeq NM_028639.4) ENSMUST00000041110.1 ENSMUST00000041110.10 ENSMUST00000041110.11 ENSMUST00000041110.2 ENSMUST00000041110.3 ENSMUST00000041110.4 ENSMUST00000041110.5 ENSMUST00000041110.6 ENSMUST00000041110.7 ENSMUST00000041110.8 ENSMUST00000041110.9 NM_028639 Q80XT5 Q8BGB2 TTC7A_MOUSE Ttc7a uc008duv.1 uc008duv.2 uc008duv.3 uc008duv.4 Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (By similarity). In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity). Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2) (By similarity). Interacts with PI4KA, interaction is direct (By similarity). Interacts with EFR3 (EFR3A or EFR3B), interaction is direct (By similarity). Interacts with HYCC (HYCC1 or HYCC2), interaction is direct (By similarity). Association with the PI4K complex is strongly reduced by TMEM150A (By similarity). Cytoplasm Cell membrane Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with EFR3 (EFR3A or EFR3B). cytoplasm plasma membrane cellular iron ion homeostasis membrane hemopoiesis phosphatidylinositol phosphorylation protein localization to plasma membrane uc008duv.1 uc008duv.2 uc008duv.3 uc008duv.4 
ENSMUST00000041111.10 Sem1 ENSMUST00000041111.10 SEM1, 26S proteasome complex subunit (from RefSeq NM_009169.2) ENSMUST00000041111.1 ENSMUST00000041111.2 ENSMUST00000041111.3 ENSMUST00000041111.4 ENSMUST00000041111.5 ENSMUST00000041111.6 ENSMUST00000041111.7 ENSMUST00000041111.8 ENSMUST00000041111.9 NM_009169 Q3TV35 Q3TV35_MOUSE Sem1 Shfm1 uc009aws.1 uc009aws.2 uc009aws.3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. Nucleus Belongs to the DSS1/SEM1 family. proteasome complex mRNA export from nucleus proteasome regulatory particle, lid subcomplex proteasome assembly uc009aws.1 uc009aws.2 uc009aws.3 
ENSMUST00000041115.7 Erich6 ENSMUST00000041115.7 glutamate rich 6 (from RefSeq NM_001081262.1) D3Z6S9 ENSMUST00000041115.1 ENSMUST00000041115.2 ENSMUST00000041115.3 ENSMUST00000041115.4 ENSMUST00000041115.5 ENSMUST00000041115.6 ERIP6_MOUSE Fam194a NM_001081262 uc008phy.1 uc008phy.2 Belongs to the ERICH6 family. molecular_function cellular_component biological_process uc008phy.1 uc008phy.2 
ENSMUST00000041124.13 Zfp704 ENSMUST00000041124.13 zinc finger protein 704 (from RefSeq NM_133218.2) ENSMUST00000041124.1 ENSMUST00000041124.10 ENSMUST00000041124.11 ENSMUST00000041124.12 ENSMUST00000041124.2 ENSMUST00000041124.3 ENSMUST00000041124.4 ENSMUST00000041124.5 ENSMUST00000041124.6 ENSMUST00000041124.7 ENSMUST00000041124.8 ENSMUST00000041124.9 Gig1 NM_133218 Q7TQL8 Q8BJW9 Q9ERQ3 ZN704_MOUSE Zfp704 Znf704 uc012cnh.1 uc012cnh.2 uc012cnh.3 Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. Nucleus Expressed from embryonic stage 9.5 dpc to 14.5 dpc. Detected in tissues from all three germ layers, with particularly strong expression in mesodermal derivatives. Strongly expressed in somites and also detected in limb bud mesenchyme, apical epidermal ridge (AER), otic vesicle, and nephrogenic mesenchyme. Expression in somites follows an anterior-to-posterior gradient of activation and localizes to somite myotomes. In limbs, first detected at stage 10.5 dpc, probably in a subset of muscle precursor cells. Expression in developing muscles continues during stage 14.5 dpc. Found in a subset of tendon precursors, particularly in the distal region of the limb. Also detected in ectoderm at the digit tips. Other notable sites of expression at stage 11.5 dpc include skin epithelium in the posterior embryo, thyroid rudiment, ventral neural tube, roof plate, floor plate, dorsal aorta, sympathetic chain ganglia, endolymphatic duct, otic vesicle epithelium and vascular wall. The CR1 and CR2 motifs mediate sequence-specific DNA binding, and are important for binding to the MYOD1 enhancer. No visible phenotype. enhancer sequence-specific DNA binding nucleic acid binding DNA binding nucleus regulation of transcription from RNA polymerase II promoter metal ion binding uc012cnh.1 uc012cnh.2 uc012cnh.3 
ENSMUST00000041126.9 Ss18l1 ENSMUST00000041126.9 SS18, nBAF chromatin remodeling complex subunit like 1 (from RefSeq NM_178750.5) CREST_MOUSE Crest ENSMUST00000041126.1 ENSMUST00000041126.2 ENSMUST00000041126.3 ENSMUST00000041126.4 ENSMUST00000041126.5 ENSMUST00000041126.6 ENSMUST00000041126.7 ENSMUST00000041126.8 Kiaa0693 NM_178750 Q6A014 Q7TQF3 Q8BW22 Q8BYQ7 uc008oic.1 uc008oic.2 uc008oic.3 uc008oic.4 Transcriptional activator which is required for calcium- dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Homodimer. Dimerization may be necessary for its function in neuronal dendritic development. Interacts (via C-terminus) with CREBBP (via N-terminus), EP300 and SMARCA4/BRG1. Interacts with the nBAF complex. Association with CREBBP facilitates transcription while the association with SMARCA4/BRG1 suppresses CREST-mediated transcription in resting neurons (By similarity). Nucleus Chromosome, centromere, kinetochore Note=Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity). The MFD (multi-functional domain) domain is involved in transcription transactivation, nuclear body targeting and dimerization. Mice are smaller than littermates and show coordination defects. There is increased mortality in beginning at about P14, and about 80% die by P28. Less than 20% survive to adulthood, and they are infertile. Belongs to the SS18 family. chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed nuclear chromosome, centromeric region DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity nucleus chromosome cytosol chromatin organization regulation of transcription, DNA-templated dendrite development nuclear body positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of dendrite development positive regulation of dendrite morphogenesis nBAF complex uc008oic.1 uc008oic.2 uc008oic.3 uc008oic.4 
ENSMUST00000041133.10 Fam110c ENSMUST00000041133.10 family with sequence similarity 110, member C (from RefSeq NM_027828.2) ENSMUST00000041133.1 ENSMUST00000041133.2 ENSMUST00000041133.3 ENSMUST00000041133.4 ENSMUST00000041133.5 ENSMUST00000041133.6 ENSMUST00000041133.7 ENSMUST00000041133.8 ENSMUST00000041133.9 F110C_MOUSE NM_027828 Q8VE94 Q9D322 uc007nhb.1 uc007nhb.2 uc007nhb.3 May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. Interacts with AKT1; the interaction is transient and follows AKT1 activation. Interacts with PPP2CA and alpha-tubulin. Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Nucleus Note=Colocalizes with microtubules during interphase. Detected at the mitotic spindle poles. Colocalizes with AKT1 at the cell cortex. Belongs to the FAM110 family. spindle pole nucleus cytoplasm microtubule organizing center cytoskeleton microtubule cell cortex positive regulation of cell migration alpha-tubulin binding positive regulation of protein kinase B signaling regulation of cell projection assembly uc007nhb.1 uc007nhb.2 uc007nhb.3 
ENSMUST00000041138.3 Elac1 ENSMUST00000041138.3 elaC ribonuclease Z 1 (from RefSeq NM_053255.3) ENSMUST00000041138.1 ENSMUST00000041138.2 NM_053255 Q8VEB6 Q9CXB1 Q9ERF4 RNZ1_MOUSE uc008fow.1 uc008fow.2 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Specifically involved in tRNA repair: acts downstream of the ribosome-associated quality control (RQC) pathway by removing a 2',3'-cyclic phosphate from tRNAs following cleavage by ANKZF1. tRNAs are then processed by TRNT1. Reaction=Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.; EC=3.1.26.11; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions. ; Homodimer. Cytoplasm, cytosol Nucleus Note=Mainly cytosolic. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VEB6-1; Sequence=Displayed; Name=2; IsoId=Q8VEB6-2; Sequence=VSP_009167; Belongs to the RNase Z family. nuclease activity endonuclease activity nucleus cytoplasm cytosol tRNA processing hydrolase activity endoribonuclease activity, producing 5'-phosphomonoesters tRNA 3'-trailer cleavage, endonucleolytic tRNA 3'-trailer cleavage 3'-tRNA processing endoribonuclease activity metal ion binding RNA phosphodiester bond hydrolysis, endonucleolytic uc008fow.1 uc008fow.2 
ENSMUST00000041139.9 Rab8b ENSMUST00000041139.9 RAB8B, member RAS oncogene family (from RefSeq NM_173413.3) ENSMUST00000041139.1 ENSMUST00000041139.2 ENSMUST00000041139.3 ENSMUST00000041139.4 ENSMUST00000041139.5 ENSMUST00000041139.6 ENSMUST00000041139.7 ENSMUST00000041139.8 NM_173413 Q0PD49 Q0PD49_MOUSE Rab8B Rab8b uc009qfk.1 uc009qfk.2 uc009qfk.3 uc009qfk.4 Cell membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side Membrane ; Lipid-anchor ; Cytoplasmic side Belongs to the small GTPase superfamily. Rab family. GTPase activity receptor binding GTP binding nucleoplasm peroxisomal membrane plasma membrane nuclear body GDP binding antigen processing and presentation TPR domain binding positive regulation of cell projection organization cytoplasmic vesicle adherens junction organization intracellular membrane-bounded organelle protein import into peroxisome membrane phagocytic vesicle perinuclear region of cytoplasm cell tip positive regulation of corticotropin secretion presynapse uc009qfk.1 uc009qfk.2 uc009qfk.3 uc009qfk.4 
ENSMUST00000041142.4 Muc1 ENSMUST00000041142.4 mucin 1, transmembrane (from RefSeq NM_013605.2) A0A0R4J0H1 A0A0R4J0H1_MOUSE ENSMUST00000041142.1 ENSMUST00000041142.2 ENSMUST00000041142.3 Muc1 NM_013605 uc008pyh.1 uc008pyh.2 uc008pyh.3 uc008pyh.4 Apical cell membrane ; Single-pass type I membrane protein Cell membrane ; Single-pass type I membrane protein Cytoplasm Membrane ; Single-pass type I membrane protein Nucleus membrane integral component of membrane uc008pyh.1 uc008pyh.2 uc008pyh.3 uc008pyh.4 
ENSMUST00000041160.13 Gng10 ENSMUST00000041160.13 guanine nucleotide binding protein (G protein), gamma 10 (from RefSeq NM_025277.3) A2ALW6 ENSMUST00000041160.1 ENSMUST00000041160.10 ENSMUST00000041160.11 ENSMUST00000041160.12 ENSMUST00000041160.2 ENSMUST00000041160.3 ENSMUST00000041160.4 ENSMUST00000041160.5 ENSMUST00000041160.6 ENSMUST00000041160.7 ENSMUST00000041160.8 ENSMUST00000041160.9 GBG10_MOUSE NM_025277 Q56A84 Q9CXP8 uc008szp.1 uc008szp.2 uc008szp.3 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3 (By similarity). G proteins are composed of 3 units, alpha, beta and gamma. Cell membrane ; Lipid-anchor ; Cytoplasmic side Belongs to the G protein gamma family. GTPase activity heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane G-protein beta/gamma-subunit complex G-protein beta-subunit binding uc008szp.1 uc008szp.2 uc008szp.3 
ENSMUST00000041163.5 Wnt8b ENSMUST00000041163.5 wingless-type MMTV integration site family, member 8B (from RefSeq NM_011720.4) ENSMUST00000041163.1 ENSMUST00000041163.2 ENSMUST00000041163.3 ENSMUST00000041163.4 NM_011720 Q8BQD1 Q8BQD1_MOUSE Wnt8b uc008hpt.1 uc008hpt.2 uc008hpt.3 Ligand for members of the frizzled family of seven transmembrane receptors. Secreted, extracellular space, extracellular matrix Belongs to the Wnt family. receptor binding extracellular region multicellular organism development Wnt signaling pathway receptor agonist activity canonical Wnt signaling pathway uc008hpt.1 uc008hpt.2 uc008hpt.3 
ENSMUST00000041180.7 Taar9 ENSMUST00000041180.7 trace amine-associated receptor 9 (from RefSeq NM_001010831.1) B2RT07 ENSMUST00000041180.1 ENSMUST00000041180.2 ENSMUST00000041180.3 ENSMUST00000041180.4 ENSMUST00000041180.5 ENSMUST00000041180.6 NM_001010831 Q5QD04 TAAR9_MOUSE uc007eqr.1 uc007eqr.2 Orphan olfactory receptor specific for trace amines. Cell membrane ; Multi-pass membrane protein Specifically expressed in neurons of the olfactory epithelium. Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2- phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled amine receptor activity membrane integral component of membrane uc007eqr.1 uc007eqr.2 
ENSMUST00000041183.7 Meox2 ENSMUST00000041183.7 mesenchyme homeobox 2 (from RefSeq NM_008584.4) ENSMUST00000041183.1 ENSMUST00000041183.2 ENSMUST00000041183.3 ENSMUST00000041183.4 ENSMUST00000041183.5 ENSMUST00000041183.6 Gax MEOX2_MOUSE Meox2 Mox-2 Mox2 NM_008584 P32443 Q544T6 uc007nkf.1 uc007nkf.2 uc007nkf.3 Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (PubMed:12925591, PubMed:10403250, PubMed:1363541). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (PubMed:10403250). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed:16116430). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (By similarity). While it activates CDKN1A in a DNA- dependent manner, it activates CDKN2A in a DNA-independent manner (By similarity). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (PubMed:25561514). Interacts with RNF10 (By similarity). Interacts with TCF15 (PubMed:25561514). Nucleus Nucleus speckle It is not expressed before 8-8.5 dpc (PubMed:1363541). At 8-8.5 dpc it is found on the entire epithelium of the somite (PubMed:1363541). At 9.5 dpc its expression is restricted to the sclerotome (PubMed:1363541). At 10.5 dpc it is found in sclerotomally derived cells including the vertebral and costal precursors (PubMed:1363541). The polyhistidine repeat may act as a targeting signal to nuclear speckles. Mice display defective differentiation and morphogenesis of the limb muscles, characterized by an overall reduction in muscle mass and elimination of specific muscles (PubMed:10403250, PubMed:12925591). Embryos also display a cleft palate phenotype at 15.5 dpc (PubMed:16284941). Mice lacking Meox1 and Meox2 show extremely disrupted somite morphogenesis, patterning and differentiation (PubMed:12925591). They lack an axial skeleton and skeletal muscles are severely deficient (PubMed:12925591). RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis somite specification DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated multicellular organism development skeletal muscle tissue development nuclear speck sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter palate development limb development somite development negative regulation of cell migration involved in sprouting angiogenesis uc007nkf.1 uc007nkf.2 uc007nkf.3 
ENSMUST00000041190.17 Mcrs1 ENSMUST00000041190.17 microspherule protein 1, transcript variant 1 (from RefSeq NM_016766.4) ENSMUST00000041190.1 ENSMUST00000041190.10 ENSMUST00000041190.11 ENSMUST00000041190.12 ENSMUST00000041190.13 ENSMUST00000041190.14 ENSMUST00000041190.15 ENSMUST00000041190.16 ENSMUST00000041190.2 ENSMUST00000041190.3 ENSMUST00000041190.4 ENSMUST00000041190.5 ENSMUST00000041190.6 ENSMUST00000041190.7 ENSMUST00000041190.8 ENSMUST00000041190.9 MCRS1_MOUSE Msp58 NM_016766 O35255 Q32P11 Q99L90 uc007xpb.1 uc007xpb.2 uc007xpb.3 Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homomer poly(G) and poly(U). Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with NOP2. Interacts with PINX1. Interacts with TERT. Interacts with CCDC85B. Interacts with DAXX. Interacts (via N-terminus) with FMR1 (via phosphorylated form). Interacts with FXR1 and FXR2. Nucleus Nucleus, nucleolus Cytoplasm Note=In microspherules in the nucleolus. histone acetyltransferase complex G-quadruplex RNA binding nucleus nucleoplasm nucleolus cytoplasm endoplasmic reticulum polysome DNA repair DNA recombination chromatin organization cellular response to DNA damage stimulus poly(U) RNA binding telomerase inhibitor activity dendrite Ino80 complex poly(G) binding perikaryon histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) NSL complex positive regulation of transcription from RNA polymerase II promoter histone acetyltransferase activity (H4-K16 specific) negative regulation of telomerase activity MLL1 complex negative regulation of telomere maintenance via telomere lengthening positive regulation of protein localization to nucleolus uc007xpb.1 uc007xpb.2 uc007xpb.3 
ENSMUST00000041195.6 Ccdc81 ENSMUST00000041195.6 coiled-coil domain containing 81 (from RefSeq NM_001162979.1) A1L0U4 CCD81_MOUSE ENSMUST00000041195.1 ENSMUST00000041195.2 ENSMUST00000041195.3 ENSMUST00000041195.4 ENSMUST00000041195.5 NM_001162979 Q9D5W4 uc009igg.1 uc009igg.2 uc009igg.3 uc009igg.4 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton biological_process uc009igg.1 uc009igg.2 uc009igg.3 uc009igg.4 
ENSMUST00000041203.6 Cpne9 ENSMUST00000041203.6 copine family member IX (from RefSeq NM_170673.3) A0A0R4J0J1 A0A0R4J0J1_MOUSE Cpne9 ENSMUST00000041203.1 ENSMUST00000041203.2 ENSMUST00000041203.3 ENSMUST00000041203.4 ENSMUST00000041203.5 NM_170673 uc033itx.1 uc033itx.2 uc033itx.3 Belongs to the copine family. positive regulation of dendrite extension uc033itx.1 uc033itx.2 uc033itx.3 
ENSMUST00000041208.9 Aaas ENSMUST00000041208.9 achalasia, adrenocortical insufficiency, alacrimia (from RefSeq NM_153416.2) AAAS_MOUSE ENSMUST00000041208.1 ENSMUST00000041208.2 ENSMUST00000041208.3 ENSMUST00000041208.4 ENSMUST00000041208.5 ENSMUST00000041208.6 ENSMUST00000041208.7 ENSMUST00000041208.8 NM_153416 P58742 Q544M6 uc007xvl.1 uc007xvl.2 uc007xvl.3 uc007xvl.4 Plays a role in the normal development of the peripheral and central nervous system. Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment. Interacts with NDC1, the interaction is required for nuclear pore localization. Interacts with the inactive form aurora kinase AURKA. Interacts with PGRMC2 (By similarity). Nucleus, nuclear pore complex Cytoplasm, cytoskeleton, spindle pole Nucleus envelope Note=In metaphase cells localizes within the spindle with some accumulation around spindle poles, with the highest concentration between the centrosome and metaphase plate. The localization to the spindle is microtubule-mediated. Widely expressed. Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung. Female mutants are sterile due to delayed oocyte maturation and meiotic spindle assembly. spindle pole microtubule bundle formation molecular_function nucleus nuclear pore nucleoplasm cytoplasm centrosome cytosol cytoskeleton nucleocytoplasmic transport learning fertilization protein transport nuclear membrane mRNA transport mitotic spindle mitotic spindle assembly uc007xvl.1 uc007xvl.2 uc007xvl.3 uc007xvl.4 
ENSMUST00000041226.11 Muc17 ENSMUST00000041226.11 mucin 17, cell surface associated (from RefSeq NM_010843.2) E9PWP7 E9PWP7_MOUSE ENSMUST00000041226.1 ENSMUST00000041226.10 ENSMUST00000041226.2 ENSMUST00000041226.3 ENSMUST00000041226.4 ENSMUST00000041226.5 ENSMUST00000041226.6 ENSMUST00000041226.7 ENSMUST00000041226.8 ENSMUST00000041226.9 Muc17 NM_010843 uc029vpi.1 uc029vpi.2 uc029vpi.3 cytoplasm microvillus biological_process membrane integral component of membrane apical plasma membrane uc029vpi.1 uc029vpi.2 uc029vpi.3 
ENSMUST00000041231.14 Psme4 ENSMUST00000041231.14 proteasome (prosome, macropain) activator subunit 4 (from RefSeq NM_134013.3) C4IXU5 ENSMUST00000041231.1 ENSMUST00000041231.10 ENSMUST00000041231.11 ENSMUST00000041231.12 ENSMUST00000041231.13 ENSMUST00000041231.2 ENSMUST00000041231.3 ENSMUST00000041231.4 ENSMUST00000041231.5 ENSMUST00000041231.6 ENSMUST00000041231.7 ENSMUST00000041231.8 ENSMUST00000041231.9 Kiaa0077 NM_134013 PSME4_MOUSE Q3TER7 Q3V2B7 Q5SSW2 Q6ZQJ7 Q7TMY9 Q8K0K0 Q99KM2 Q9ESY1 uc007ihx.1 uc007ihx.2 uc007ihx.3 Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. Homodimer. Interacts with the 20S and 26S proteasomes. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Cytoplasm, cytosol. Nucleus. Nucleus speckle Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SSW2-1; Sequence=Displayed; Name=2; IsoId=Q5SSW2-2; Sequence=VSP_023880; Broadly expressed. Present in heart (at protein level). The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones. Phosphorylated. Mice are viable and show no obvious developmental abnormalities. They have reduced male fertility due to defects in spermatogenesis in meiotic spermatocytes and during the maturation of postmeiotic haploid spermatids. Testes are defective in core histone replacement. Belongs to the BLM10 family. Sequence=AAG09060.1; Type=Frameshift; Evidence=; Sequence=BAC97859.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; proteasome complex nucleus nucleoplasm cytoplasm cytosol DNA repair cellular response to DNA damage stimulus multicellular organism development spermatogenesis proteasomal ubiquitin-independent protein catabolic process positive regulation of peptidase activity peptidase activator activity nuclear speck cell differentiation spermatogenesis, exchange of chromosomal proteins lysine-acetylated histone binding proteasome binding spermatoproteasome complex uc007ihx.1 uc007ihx.2 uc007ihx.3 
ENSMUST00000041240.4 Shisa4 ENSMUST00000041240.4 shisa family member 4 (from RefSeq NM_175259.5) ENSMUST00000041240.1 ENSMUST00000041240.2 ENSMUST00000041240.3 NM_175259 Q8CA71 SHSA4_MOUSE Tmem58 uc007ctc.1 uc007ctc.2 uc007ctc.3 Membrane ; Single-pass type I membrane protein Belongs to the shisa family. membrane integral component of membrane uc007ctc.1 uc007ctc.2 uc007ctc.3 
ENSMUST00000041252.13 Acad12 ENSMUST00000041252.13 acyl-Coenzyme A dehydrogenase family, member 12 (from RefSeq NM_178799.3) Acad12 D3Z7X0 D3Z7X0_MOUSE ENSMUST00000041252.1 ENSMUST00000041252.10 ENSMUST00000041252.11 ENSMUST00000041252.12 ENSMUST00000041252.2 ENSMUST00000041252.3 ENSMUST00000041252.4 ENSMUST00000041252.5 ENSMUST00000041252.6 ENSMUST00000041252.7 ENSMUST00000041252.8 ENSMUST00000041252.9 NM_178799 uc008zjv.1 uc008zjv.2 uc008zjv.3 uc008zjv.4 Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Belongs to the acyl-CoA dehydrogenase family. mitochondrion oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors flavin adenine dinucleotide binding oxidation-reduction process uc008zjv.1 uc008zjv.2 uc008zjv.3 uc008zjv.4 
ENSMUST00000041262.14 Churc1 ENSMUST00000041262.14 churchill domain containing 1, transcript variant 1 (from RefSeq NM_206534.2) CHUR_MOUSE ENSMUST00000041262.1 ENSMUST00000041262.10 ENSMUST00000041262.11 ENSMUST00000041262.12 ENSMUST00000041262.13 ENSMUST00000041262.2 ENSMUST00000041262.3 ENSMUST00000041262.4 ENSMUST00000041262.5 ENSMUST00000041262.6 ENSMUST00000041262.7 ENSMUST00000041262.8 ENSMUST00000041262.9 NM_206534 Q6DG52 Q8VCP1 uc007nyq.1 uc007nyq.2 uc007nyq.3 uc007nyq.4 Transcriptional activator that mediates FGF signaling during neural development (By similarity). Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6DG52-1; Sequence=Displayed; Name=2; IsoId=Q6DG52-2; Sequence=VSP_013378, VSP_013379; Belongs to the Churchill family. DNA binding nucleus multicellular organism development mesoderm development zinc ion binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding uc007nyq.1 uc007nyq.2 uc007nyq.3 uc007nyq.4 
ENSMUST00000041264.15 Zfp938 ENSMUST00000041264.15 zinc finger protein 938, transcript variant 3 (from RefSeq NM_001379438.1) E9Q9G3 E9Q9G3_MOUSE ENSMUST00000041264.1 ENSMUST00000041264.10 ENSMUST00000041264.11 ENSMUST00000041264.12 ENSMUST00000041264.13 ENSMUST00000041264.14 ENSMUST00000041264.2 ENSMUST00000041264.3 ENSMUST00000041264.4 ENSMUST00000041264.5 ENSMUST00000041264.6 ENSMUST00000041264.7 ENSMUST00000041264.8 ENSMUST00000041264.9 NM_001379438 Zfp938 uc007gjm.1 uc007gjm.2 uc007gjm.3 uc007gjm.4 uc007gjm.5 molecular_function nucleic acid binding nucleus regulation of transcription, DNA-templated metal ion binding uc007gjm.1 uc007gjm.2 uc007gjm.3 uc007gjm.4 uc007gjm.5 
ENSMUST00000041265.4 Lbx2 ENSMUST00000041265.4 ladybird homeobox 2 (from RefSeq NM_010692.4) ENSMUST00000041265.1 ENSMUST00000041265.2 ENSMUST00000041265.3 LBX2_MOUSE Lbx2h NM_010692 Q32M12 Q9WUN8 uc009cmi.1 uc009cmi.2 uc009cmi.3 Transcription factor. Nucleus Expressed in the developing urogenital system, eye and brain. First detected at 10.5 dpc in the gonadal component of the urogenital ridge. Expression dramatically increases by 11.5 dpc in the urogenital ridges and in the cranial surface ectoderm. At this time, it is also expressed in the trigeminal ganglion and nodose ganglion. At later stages, it is expressed in the brain and organs derived from the urogenital ridge, including the gonadal tubercle, kidneys, and adrenal glands. From 14.5 dpc to birth, expression is evident in the developing retinal neuroepithelium and the vibrissa. By PAX3 which regulates its expression. Mice are healthy and fertile and do not display any abnormal phenotype. DNA binding nucleus biological_process uc009cmi.1 uc009cmi.2 uc009cmi.3 
ENSMUST00000041272.10 Plekhm1 ENSMUST00000041272.10 pleckstrin homology domain containing, family M (with RUN domain) member 1 (from RefSeq NM_183034.2) ENSMUST00000041272.1 ENSMUST00000041272.2 ENSMUST00000041272.3 ENSMUST00000041272.4 ENSMUST00000041272.5 ENSMUST00000041272.6 ENSMUST00000041272.7 ENSMUST00000041272.8 ENSMUST00000041272.9 NM_183034 PKHM1_MOUSE Plekhm1 Q3U3L2 Q7TSI1 Q8CHU5 uc007lug.1 uc007lug.2 uc007lug.3 Acts as a multivalent adapter protein that regulates Rab7- dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7. May have a role in sialyl-lex-mediated transduction of apoptotic signals (By similarity). Involved in bone resorption (PubMed:27777970). Interacts (via N- and C-terminus) with RAB7A (GTP-bound form). Simultaneously interacts with RAB7A and ARL8B; bringing about clustering and fusion of late endosomes and lysosomes. Interacts (via RUN domain) with ARL8B (GTP-bound form); the interaction is required for PLEKHM1 localization to lysosomes and for ARL8B function in delivery and degradation of endocytic and autophagic cargo in lysosomes. PLEKHM1 and PLEKHM2 compete for interaction with ARL8B. Interacts with ARL8A; the interaction is weaker than with ARL8B. Interacts with VPS41, VPS11, VPS18, VPS33A and VPS39; indicative for an association with the HOPS complex; the interactions with, at least, VPS41, VPS11, VPS18 and VPS33A require ARL8B (By similarity). Interacts with GABARAP, GABARAPL, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C (By similarity). Interacts with PAFAH1B (PubMed:22073305). Interacts (via N- and C-terminus) with NDEL1 (PubMed:27777970). Interacts (via C- terminus) with MAP3K7 (PubMed:27777970). Interacts (via N- and C- terminus) with FAM98A (PubMed:27777970). Interacts (via C-terminus) with DEF8; this interaction is weak but increased in a RAB7A-dependent manner (PubMed:27777970). May interact with sialyl-lex-positive protein (By similarity). Autolysosome membrane Endosome membrane Late endosome membrane Lysosome membrane Note=In case of infection colocalizes with Salmonella typhimurium sifA in proximity of Salmonella-containing vacuole (SCV). The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins GABARAP, GABARAPL, GABARAPL2, and LC3A/B/C. Osteoclast-specific conditional knockout mice show normal tooth eruption, developed normally and are fertile, but trabecular bone mass in long bones and vertebrae is increased (PubMed:27777970). Osteoclast differentiation and number are normal, but bone resorption is decreased (PubMed:27777970). Show mislocalization of osteoclast lysosomes at the perinuclear area, instead at the cell periphery, and decreased ruffled border formation (PubMed:27777970). Sialyl-lex is a carcinoma associated antigen. protein binding nucleolus cytoplasm lysosome lysosomal membrane endosome autophagy endosome membrane protein transport membrane lysosome localization intracellular signal transduction intracellular membrane-bounded organelle positive regulation of bone resorption metal ion binding positive regulation of ruffle assembly uc007lug.1 uc007lug.2 uc007lug.3 
ENSMUST00000041282.13 Trim37 ENSMUST00000041282.13 tripartite motif-containing 37, transcript variant 2 (from RefSeq NM_197987.2) ENSMUST00000041282.1 ENSMUST00000041282.10 ENSMUST00000041282.11 ENSMUST00000041282.12 ENSMUST00000041282.2 ENSMUST00000041282.3 ENSMUST00000041282.4 ENSMUST00000041282.5 ENSMUST00000041282.6 ENSMUST00000041282.7 ENSMUST00000041282.8 ENSMUST00000041282.9 Kiaa0898 NM_197987 Q5SX31 Q6PCX9 Q8CHC5 TRI37_MOUSE Trim37 uc007ktm.1 uc007ktm.2 uc007ktm.3 uc007ktm.4 The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which is typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. In mouse this protein is proposed to oligomerize through its coiled coil domain and has been reported to be expressed in neural crest-derived tissues as well as in tissues whose development is regulated by mesenchymal-epithelial interactions. In humans, mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder characterized by prenatal onset growth failure, cardiomyopathy and dysmorphic features. [provided by RefSeq, Jan 2013]. ##Evidence-Data-START## Transcript exon combination :: AK140822.1, BC058678.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## E3 ubiquitin-protein ligase required to prevent centriole reduplication (By similarity). Probably acts by ubiquitinating positive regulators of centriole reduplication (By similarity). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Associates with the PRC2/EED-EZH2 complex. Chromosome Cytoplasm, perinuclear region Peroxisome membrane ; Peripheral membrane protein Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. Highly expressed in testis and brain. In embryonic tissues, expressed in epithelia, including ducts of the developing pancreas, epithelium of the midgut and nasal epithelium. In adult, detected in the central and peripheral nervous systems, including enteric ganglia, retina and the adrenal medulla (at protein level). Auto-ubiquitinated. Belongs to the TRIM/RBCC family. Sequence=BAC41455.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter chromatin binding ubiquitin-protein transferase activity tumor necrosis factor receptor binding cytoplasm peroxisome cytosol zinc ion binding aggresome protein ubiquitination transferase activity ubiquitin protein ligase binding negative regulation of NF-kappaB transcription factor activity ESC/E(Z) complex histone H2A monoubiquitination histone H2A-K119 monoubiquitination protein homodimerization activity negative regulation of centriole replication metal ion binding perinuclear region of cytoplasm positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein autoubiquitination ubiquitin protein ligase activity aggresome assembly uc007ktm.1 uc007ktm.2 uc007ktm.3 uc007ktm.4 
ENSMUST00000041284.10 Patj ENSMUST00000041284.10 PATJ, crumbs cell polarity complex component, transcript variant 1 (from RefSeq NM_172696.2) A2ADS7 Cipp ENSMUST00000041284.1 ENSMUST00000041284.2 ENSMUST00000041284.3 ENSMUST00000041284.4 ENSMUST00000041284.5 ENSMUST00000041284.6 ENSMUST00000041284.7 ENSMUST00000041284.8 ENSMUST00000041284.9 INADL_MOUSE Inadl NM_172696 O70471 Patj Q5PRG3 Q63ZW7 Q6P6J1 Q80YR8 Q8BPB9 uc008tuc.1 uc008tuc.2 uc008tuc.3 This gene encodes a multivalent PDZ domain protein, which is expressed exclusively in brain and kidney. This protein selectively interacts with inward rectifier K+ (Kir) family members, N-methyl-D-aspartate receptor subunits, neurexins and neuroligins, as well as cell surface molecules enriched in synaptic membranes. Thus, this protein may serve as a scaffold that brings structurally diverse but functionally connected proteins into close proximity at the synapse. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11872753). Required for the correct formation of tight junctions and epithelial apico-basal polarity (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (PubMed:11872753). May recruit ARHGEF18 to apical cell-cell boundaries (By similarity). Forms a ternary complex with PALS1 and CRB1 (By similarity). Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, INADL/PATJ and PARD3/PAR3 (By similarity). Forms a heterotrimeric complex composed of MMP5, LIN7B and PATJ; the N-terminal L27 domain of PALS1 interacts with the L27 domain of PATJ and the C-terminal L27 domain of PALS1 interacts with the L27 domain of LIN7B (By similarity). Component of a complex composed of CRB3, PALS1 and PATJ (By similarity). Interacts (via N-terminus) with PALS1/PALS (via PDZ domain) (PubMed:12527193, PubMed:20399730). Interacts with TJP3/ZO-3 and CLDN1/claudin-1 (By similarity). Interacts with ASIC3, KCNJ10, KCNJ15, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NLGN2, and HTR2A (PubMed:9647694, PubMed:11872753, PubMed:14988405). Interacts with MPP7 (By similarity). Directly interacts with HTR4 (PubMed:15466885). Interacts (via PDZ domain 8) with WWC1 (via the ADDV motif) (By similarity). Interacts with SLC6A4 (PubMed:17452640). Interacts (via C- terminus) with ARHGEF18 (By similarity). Interacts with NPHP1 (By similarity). Interacts with PARD3/PAR3 (By similarity). [Isoform 2]: Interacts with NRXN2. Q63ZW7; P35436: Grin2a; NbExp=4; IntAct=EBI-8366894, EBI-400115; Q63ZW7; Q00960: Grin2b; Xeno; NbExp=4; IntAct=EBI-8366894, EBI-396905; Q63ZW7; Q00961: Grin2c; Xeno; NbExp=2; IntAct=EBI-8366894, EBI-631045; Q63ZW7; Q62645: Grin2d; Xeno; NbExp=3; IntAct=EBI-8366894, EBI-631067; Q63ZW7; Q99712: KCNJ15; Xeno; NbExp=4; IntAct=EBI-8366894, EBI-7082607; Q63ZW7-3; O35240: Asic3; Xeno; NbExp=2; IntAct=EBI-8158524, EBI-982374; Cell junction, tight junction Apical cell membrane ; Peripheral membrane protein Cytoplasm, perinuclear region Note=Localizes to the apical region at the start of epithelial cell polarization then locates to tight junctions as polarization is completed (By similarity). Localized in the paranodal region of myelinating Schwann cells (PubMed:12403818). Localized to the leading edge of the actin cortex of migrating epithelia cells (By similarity). [Isoform 3]: Cytoplasm. Cytoplasm, perinuclear region. Note=Concentrates around the nucleus upon HTR2A coexpression. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q63ZW7-1; Sequence=Displayed; Name=2; IsoId=Q63ZW7-2; Sequence=VSP_014211; Name=3; IsoId=Q63ZW7-3; Sequence=VSP_014210, VSP_014216; Name=4; IsoId=Q63ZW7-4; Sequence=VSP_014210, VSP_014216, VSP_014217, VSP_014218; Name=5; IsoId=Q63ZW7-5; Sequence=VSP_014212, VSP_014213; Name=6; IsoId=Q63ZW7-6; Sequence=VSP_014214, VSP_014215; [Isoform 1]: Expressed in the kidney. [Isoform 3]: Expressed in the brain, high levels are detected in the cerebellum, inferior colliculus, vestibular nucleus, facial nucleus and thalamus (PubMed:9647694). Also detected in deep cerebellar nuclei, superior colliculus, dorsal transition zone, brain stem, as well as the glomerular and mitral cell layers of the olfactory bulb (PubMed:9647694). Within the cerebellum it is expressed in both Purkinje and granule cell layers (PubMed:9647694). Expressed apically in the cortical neuroepithelium along the ventricular surface at 14.5 dpc. The L27 domain (also called Maguk recruitment domain) is required for interaction with PALS1 and CRB3, and PALS1 localization to tight junctions. The PDZ domain 6 mediates interaction with the C-terminus of TJP3 and is crucial for localization to the tight junctions. The PDZ domain 8 interacts with CLDN1 but is not required for proper localization (By similarity). The PDZ domain 2 of isoform 3 mediates interactions with KCNJ10, KCNJ15, GRIN2B and NLGN2. The PDZ domain 3 of isoform 3 mediates interactions with KCNJ15, GRIN2A, GRIN2B, GRIN2C, GRIN2D and NRXN2. The PDZ domain 4 of isoform 3 mediates interaction with ASIC3. protein binding cytoplasm centrosome microtubule organizing center cytosol plasma membrane bicellular tight junction membrane apical plasma membrane cell junction macromolecular complex apical part of cell perinuclear region of cytoplasm uc008tuc.1 uc008tuc.2 uc008tuc.3 
ENSMUST00000041297.15 Zbed4 ENSMUST00000041297.15 zinc finger, BED type containing 4 (from RefSeq NM_181412.4) ENSMUST00000041297.1 ENSMUST00000041297.10 ENSMUST00000041297.11 ENSMUST00000041297.12 ENSMUST00000041297.13 ENSMUST00000041297.14 ENSMUST00000041297.2 ENSMUST00000041297.3 ENSMUST00000041297.4 ENSMUST00000041297.5 ENSMUST00000041297.6 ENSMUST00000041297.7 ENSMUST00000041297.8 ENSMUST00000041297.9 Kiaa0637 NM_181412 Q3UPJ9 Q80TV3 Q80WQ9 Q8R329 ZBED4_MOUSE uc007xem.1 uc007xem.2 uc007xem.3 Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (PubMed:22693546). Homodimer; via C-terminus (By similarity). Interacts with MYH9 (By similarity). Interacts with SAFB/SAFB1 (By similarity). Cytoplasm Nucleus Photoreceptor inner segment Expressed in the thymus (PubMed:19369242). In the retina, expressed in the cone photoreceptors (PubMed:19369242, PubMed:22693546). Sequence=BAC65617.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence=; DNA binding nucleus nucleoplasm cytoplasm metal ion binding protein dimerization activity uc007xem.1 uc007xem.2 uc007xem.3 
ENSMUST00000041301.8 Pnmt ENSMUST00000041301.8 phenylethanolamine-N-methyltransferase (from RefSeq NM_008890.3) ENSMUST00000041301.1 ENSMUST00000041301.2 ENSMUST00000041301.3 ENSMUST00000041301.4 ENSMUST00000041301.5 ENSMUST00000041301.6 ENSMUST00000041301.7 NM_008890 Pnmt Q0VB50 Q0VB50_MOUSE uc007lgg.1 uc007lgg.2 uc007lgg.3 Reaction=(R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:25269, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:71406, ChEBI:CHEBI:72587; EC=2.1.1.28; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25270; Evidence=; Reaction=(R)-normetanephrine + S-adenosyl-L-methionine = (R)- metanephrine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:70683, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:189645, ChEBI:CHEBI:189646; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70684; Evidence=; Reaction=(R)-octopamine + S-adenosyl-L-methionine = (R)-synephrine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:70519, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:63694, ChEBI:CHEBI:141486; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70520; Evidence=; Reaction=phenylethanolamine + S-adenosyl-L-methionine = H(+) + N- methylphenylethanolamine + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:12176, ChEBI:CHEBI:15378, ChEBI:CHEBI:57741, ChEBI:CHEBI:57856, ChEBI:CHEBI:57946, ChEBI:CHEBI:59789; EC=2.1.1.28; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12177; Evidence=; Catecholamine biosynthesis; (R)-adrenaline biosynthesis; (R)- adrenaline from (R)-noradrenaline: step 1/1. Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. methyltransferase activity transferase activity methylation uc007lgg.1 uc007lgg.2 uc007lgg.3 
ENSMUST00000041314.17 Paip2 ENSMUST00000041314.17 polyadenylate-binding protein-interacting protein 2, transcript variant 1 (from RefSeq NM_026420.3) ENSMUST00000041314.1 ENSMUST00000041314.10 ENSMUST00000041314.11 ENSMUST00000041314.12 ENSMUST00000041314.13 ENSMUST00000041314.14 ENSMUST00000041314.15 ENSMUST00000041314.16 ENSMUST00000041314.2 ENSMUST00000041314.3 ENSMUST00000041314.4 ENSMUST00000041314.5 ENSMUST00000041314.6 ENSMUST00000041314.7 ENSMUST00000041314.8 ENSMUST00000041314.9 NM_026420 PAIP2_MOUSE Q3UBH5 Q9D6V8 Q9DAW7 uc008emj.1 uc008emj.2 uc008emj.3 uc008emj.4 Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity). Interacts with the second and third RRM domains and C-terminus regions of PABPC1 in a 2:1 stoichiometry. Cytoplasm Expressed at high levels in testis with expression also detected in heart, brain, lung, liver, kidney, pancreas and small intestine (at protein level). Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation. Ubiquitinated, leading to its degradation by the proteasome. Belongs to the PAIP2 family. translation repressor activity, nucleic acid binding mRNA binding cytoplasm regulation of translation spermatogenesis memory poly(A) binding negative regulation of translation translation repressor activity negative regulation of translational initiation regulation of long-term synaptic potentiation uc008emj.1 uc008emj.2 uc008emj.3 uc008emj.4 
ENSMUST00000041316.15 Tcl1 ENSMUST00000041316.15 T cell lymphoma breakpoint 1, transcript variant 3 (from RefSeq NR_110339.1) ENSMUST00000041316.1 ENSMUST00000041316.10 ENSMUST00000041316.11 ENSMUST00000041316.12 ENSMUST00000041316.13 ENSMUST00000041316.14 ENSMUST00000041316.2 ENSMUST00000041316.3 ENSMUST00000041316.4 ENSMUST00000041316.5 ENSMUST00000041316.6 ENSMUST00000041316.7 ENSMUST00000041316.8 ENSMUST00000041316.9 NR_110339 P56280 TCL1A_MOUSE Tcl1a uc007oyd.1 uc007oyd.2 uc007oyd.3 uc007oyd.4 uc007oyd.5 Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (By similarity). Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity (By similarity). Cytoplasm Nucleus Microsome Endoplasmic reticulum Note=Microsomal fraction. Belongs to the TCL1 family. nucleus cytoplasm endoplasmic reticulum cell cortex positive regulation of cell proliferation negative regulation of gene expression positive regulation of mitochondrial membrane potential stem cell population maintenance protein kinase binding positive regulation of protein oligomerization macromolecular complex positive regulation of peptidyl-serine phosphorylation identical protein binding negative regulation of apoptotic process intracellular membrane-bounded organelle protein serine/threonine kinase activator activity pronucleus protein homotrimerization cellular response to tumor necrosis factor positive regulation of protein serine/threonine kinase activity regulation of stem cell population maintenance uc007oyd.1 uc007oyd.2 uc007oyd.3 uc007oyd.4 uc007oyd.5 
ENSMUST00000041317.3 Ammecr1 ENSMUST00000041317.3 AMMECR nuclear protein 1 (from RefSeq NM_019496.4) AMMR1_MOUSE ENSMUST00000041317.1 ENSMUST00000041317.2 NM_019496 Q9JHT5 uc009umc.1 uc009umc.2 uc009umc.3 Nucleus molecular_function nucleus biological_process uc009umc.1 uc009umc.2 uc009umc.3 
ENSMUST00000041331.4 Scd1 ENSMUST00000041331.4 stearoyl-Coenzyme A desaturase 1 (from RefSeq NM_009127.4) ENSMUST00000041331.1 ENSMUST00000041331.2 ENSMUST00000041331.3 NM_009127 Q547C4 Q547C4_MOUSE Scd1 uc008hpr.1 uc008hpr.2 uc008hpr.3 uc008hpr.4 uc008hpr.5 Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence= Membrane ; Multi- pass membrane protein Microsome membrane The histidine box domains are involved in binding the catalytic metal ions. Belongs to the fatty acid desaturase type 1 family. stearoyl-CoA 9-desaturase activity iron ion binding lipid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process lipid biosynthetic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water intracellular membrane-bounded organelle oxidation-reduction process response to fatty acid uc008hpr.1 uc008hpr.2 uc008hpr.3 uc008hpr.4 uc008hpr.5 
ENSMUST00000041342.12 Cacna1b ENSMUST00000041342.12 calcium channel, voltage-dependent, N type, alpha 1B subunit, transcript variant 1 (from RefSeq NM_001042528.3) CAC1B_MOUSE Cach5 Cacnl1a5 Cchn1a ENSMUST00000041342.1 ENSMUST00000041342.10 ENSMUST00000041342.11 ENSMUST00000041342.2 ENSMUST00000041342.3 ENSMUST00000041342.4 ENSMUST00000041342.5 ENSMUST00000041342.6 ENSMUST00000041342.7 ENSMUST00000041342.8 ENSMUST00000041342.9 NM_001042528 O55017 Q60609 uc008ipe.1 uc008ipe.2 uc008ipe.3 uc008ipe.4 uc008ipe.5 Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Is specifically blocked by omega-conotoxin GVIA (By similarity). Is specifically blocked by omega-conotoxin MVIIA (ziconotide) (By similarity). Is insensitive to dihydropyridines (DHP). Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1 (PubMed:11438518). Interacts with FMR1 (via C-terminus); this interaction induces a decrease in the number of presynaptic functional CACNA1B channels at the cell surface (PubMed:24709664). Membrane ; Multi- pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=NB1; IsoId=O55017-1; Sequence=Displayed; Name=NB2; IsoId=O55017-2; Sequence=VSP_000883; Widespread expression throughout the brain. Highest levels in pyramidal cell layers C1, C2 and C3 of the hippocampus, in the dentate gyrus, in the cortex layers 2 et 4, in the subiculum and the habenula. Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage- sensor and are characterized by a series of positively charged amino acids at every third position. Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily. Sequence=AAB60437.1; Type=Frameshift; Evidence=; nucleotide binding positive regulation of neurotransmitter secretion ion channel activity voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity calcium ion binding protein binding ATP binding plasma membrane voltage-gated calcium channel complex ion transport calcium ion transport chemical synaptic transmission neurotransmitter secretion locomotory behavior regulation of heart contraction protein C-terminus binding regulation of blood pressure high voltage-gated calcium channel activity response to organic cyclic compound membrane integral component of membrane sensory perception of pain dendrite macromolecular complex response to testosterone regulation of ion transmembrane transport neuron projection neuronal cell body dendritic shaft axon terminus metal ion binding response to pain modulation of synaptic transmission protein phosphatase 2A binding regulation of calcium ion transport transmembrane transport calcium ion import calcium ion transmembrane transport glutamatergic synapse positive regulation of presynaptic cytosolic calcium concentration voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration response to beta-amyloid uc008ipe.1 uc008ipe.2 uc008ipe.3 uc008ipe.4 uc008ipe.5 
ENSMUST00000041357.9 Lrg1 ENSMUST00000041357.9 leucine-rich alpha-2-glycoprotein 1 (from RefSeq NM_029796.2) ENSMUST00000041357.1 ENSMUST00000041357.2 ENSMUST00000041357.3 ENSMUST00000041357.4 ENSMUST00000041357.5 ENSMUST00000041357.6 ENSMUST00000041357.7 ENSMUST00000041357.8 Lrg Lrg1 NM_029796 Q91XL1 Q91XL1_MOUSE lrhg uc008dbb.1 uc008dbb.2 uc008dbb.3 positive regulation of endothelial cell proliferation transforming growth factor beta receptor binding extracellular space response to bacterium positive regulation of transforming growth factor beta receptor signaling pathway intracellular membrane-bounded organelle positive regulation of angiogenesis brown fat cell differentiation uc008dbb.1 uc008dbb.2 uc008dbb.3 
ENSMUST00000041361.14 Zfp335 ENSMUST00000041361.14 zinc finger protein 335 (from RefSeq NM_199027.2) A2A5K6 B2RXR9 ENSMUST00000041361.1 ENSMUST00000041361.10 ENSMUST00000041361.11 ENSMUST00000041361.12 ENSMUST00000041361.13 ENSMUST00000041361.2 ENSMUST00000041361.3 ENSMUST00000041361.4 ENSMUST00000041361.5 ENSMUST00000041361.6 ENSMUST00000041361.7 ENSMUST00000041361.8 ENSMUST00000041361.9 NM_199027 Q3TZT1 ZN335_MOUSE Znf335 uc008nwr.1 uc008nwr.2 uc008nwr.3 Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (By similarity). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (By similarity). Interacts with NCOA6; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). Interacts with CNOT6 (By similarity). Interacts with CNOT9; the interaction is direct (By similarity). Component of a nuclear receptor-mediated transcription complex composed of at least ZNF335, CCAR2 and EMSY; the complex stimulates the transcription of nuclear receptor target genes such as SOX9 and HOXA1 (By similarity). Within the complex interacts with EMSY and interacts (via C-terminus) with CCAR2 (By similarity). Interacts with members of histone H3'Lys4'(H3K4) methyltransferase complexes ASH2L, CXXC1, KMT2A/MLL1, RBBP5, SETD1A and WDR5 (PubMed:23178126). Component of a histone methylation complex composed of at least ZNF335, RBBP5, ASH2L and WDR5; the complex may have histone H3-specific methyltransferase activity, however does not have specificity for 'Lys-4' of histone H3 (By similarity). Interacts with RBBP5 and WDR5 (PubMed:23178126). Interacts with ASHL2 (By similarity). Components of this complex may associate with components of the ZNF335-CCAR2-EMSY nuclear receptor-mediated transcription complex to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5 (By similarity). Within this complex also interacts with HCFC1 and MKI67 (By similarity). Nucleus Expressed at low levels in cerebral cortex, hippocampus and cerebellum (at protein level). In brain, expression peaks at 13-15 dpc, during cortical neurogenesis. At 8.5 dpc, expressed in forebrain and midbrain. At 14.5 dpc, expressed in ventricular zone, subventricular zone and cortical plate. Loss leads to embryonic lethality as early as 7.5 dpc. Brain-specific conditional knockout produces a brain with an essentially absent cortex lacking all cortical neurons. Belongs to the krueppel C2H2-type zinc-finger protein family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding in utero embryonic development positive regulation of neuroblast proliferation nucleic acid binding DNA binding protein binding nucleus nucleoplasm multicellular organism development brain development regulation of gene expression cerebral cortex neuron differentiation histone methyltransferase complex regulation of gene expression, epigenetic transcription regulatory region DNA binding metal ion binding neuron projection morphogenesis brain morphogenesis positive regulation of lymphocyte proliferation regulation of neurogenesis positive regulation of neurogenesis regulation of histone H3-K4 methylation histone H3-K4 trimethylation uc008nwr.1 uc008nwr.2 uc008nwr.3 
ENSMUST00000041362.12 Mavs ENSMUST00000041362.12 mitochondrial antiviral signaling protein, transcript variant 2 (from RefSeq NM_001206385.1) ENSMUST00000041362.1 ENSMUST00000041362.10 ENSMUST00000041362.11 ENSMUST00000041362.2 ENSMUST00000041362.3 ENSMUST00000041362.4 ENSMUST00000041362.5 ENSMUST00000041362.6 ENSMUST00000041362.7 ENSMUST00000041362.8 ENSMUST00000041362.9 Ips1 MAVS_MOUSE Mavs NM_001206385 Q8VCF0 Visa uc008mle.1 uc008mle.2 uc008mle.3 uc008mle.4 uc008mle.5 Adapter required for innate immune defense against viruses (PubMed:24037184). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5) (PubMed:24037184). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (By similarity). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (By similarity). May activate the same pathways following detection of extracellular dsRNA by TLR3 (By similarity). May protect cells from apoptosis (By similarity). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). Self-associates and polymerizes (via CARD domains) to form 400 nM long three-stranded helical filaments on mitochondria, filament nucleation requires interaction with RIGI whose CARD domains act as a template for filament assembly (By similarity). Interacts with RIGI, IFIH1/MDA5, TRAF2, TRAF6 and C1QBP (By similarity). May interact with FADD, RIPK1, IKBKE, CHUK and IKBKB (By similarity). Interacts (when phosphorylated) with IRF3; following activation and phosphorylation on the pLxIS motif by TBK1, recruits IRF3 (By similarity). Interacts with NLRX1 (By similarity). Interaction with NLRX1 requires the CARD domain (By similarity). Interacts with PSMA7 (By similarity). Interacts with TRAFD1 (PubMed:18849341). Interacts (via C-terminus) with PCBP2 in a complex containing MAVS/IPS1, PCBP2 and ITCH (By similarity). Interacts with CYLD (By similarity). Interacts with SRC (By similarity). Interacts with DHX58/LGP2 and IKBKE (By similarity). Interacts with STING1 (By similarity). Interacts with IFIT3 (via N-terminus) (By similarity). Interacts with TBK1 only in the presence of IFIT3 (By similarity). Interacts with TTLL12; the interaction prevents MAVS binding to TBK1 and IKBKE (By similarity). Interacts with MUL1 (By similarity). Interacts with ANKRD17 (By similarity). Interacts with NDFIP1 (By similarity). Interacts with SMURF1; the interaction is mediated by NDFIP1 and leads to MAVS ubiquitination and degradation (PubMed:23087404). Interacts (via C-terminus) with GPATCH3; the interaction is markedly increased upon viral infection (By similarity). Directly interacts (via CARD domain) with ATG5 and ATG12, either as ATG5 and ATG12 monomers or as ATG12-ATG5 conjugates (By similarity). Interacts with DHX33 (via the helicase C-terminal domain) (PubMed:24037184). Interacts with DDX3X (via C-terminus); this interaction may occur rapidly, but transiently after viral infection (By similarity). The interaction with DDX3X potentiates MAVS-mediated IFNB induction (By similarity). Conversely inhibition of this interaction prevents MAVS-mediated IFNB induction (By similarity). Transiently interacts with TRAF3 early during viral infection (By similarity). Interacts with CLPB (By similarity). Interacts with TRAF3IP3 (By similarity). Interacts with TOMM70; the interaction is enhanced by virus infection (By similarity). Interacts with ZNFX1 (PubMed:31685995). Interacts with DHX15 (By similarity). Interacts with N4BP3; this interaction promotes the polyubiquitination of MAVS (By similarity). Interacts with TAX1BP1; this interaction induces MAVS polyubiquitination (By similarity). Interacts with NLRP3; promoting NLRP3 recruitment to mitochondria and activation of the NLRP3 inflammasome (PubMed:23582325). Interacts with ECSIT; this interaction bridges RIGI to the MAVS complex at the mitochondrion (By similarity). Interacts with UBL7; this interaction promotes MAVS 'Lys-27'-linked ubiquitination leading to type I interferon production (By similarity). Interacts (via transmembrane domain) with SMIM30/MAVI1 (via transmembrane domain); the interaction disrupts MAVS interaction with RIGI and inhibits MAVS aggregation, resulting in the repression of type I interferon signaling and innate immune responses (By similarity). Q8VCF0; Q60803: Traf3; NbExp=4; IntAct=EBI-3862816, EBI-520135; Mitochondrion outer membrane ; Single-pass membrane protein Mitochondrion Peroxisome Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with RIGI and IFIH1/MDA5 (By similarity). The transmembrane domain and residues 285-420 are essential for its interaction with DHX58/LGP2. The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of MAVS recruits IRF3. IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and other cytokines. Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with RIGI and IFIH1/MDA5. The transmembrane domain and residues 300-444 are essential for its interaction with DHX58/LGP2. Following activation, phosphorylated by TBK1 at Ser-418 in the pLxIS motif. The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines. Ubiquitinated. Undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS/IPS1 proteasomal degradation. Ubiquitinated by RNF125, leading to its degradation by the proteasome. Undergoes 'Lys-48'-linked ubiquitination catalyzed by SMURF1. Ubiquitinated via 'Lys-63'-linked ubiquitination at Lys-10 by TRIM31, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria. Undergoes 'Lys-63'-linked ubiquitination leading to enhanced interaction between MAVS and TRAF2. Undergoes 'Lys- 27'-linked ubiquitination by UBE2N and TRIM21 leading to enhanced interaction between MAVS and TBK1 (By similarity). Deubiquitinated by USP10 leading to attenuation of RIGI-mediated MAVS aggregation and production of type I interferon (By similarity). Proteolytically cleaved by apoptotic caspases during apoptosis, leading to its inactivation. Cleavage by CASP3 during virus-induced apoptosis inactivates it, preventing cytokine overproduction. positive regulation of protein phosphorylation activation of innate immune response positive regulation of defense response to virus by host immune system process positive regulation of myeloid dendritic cell cytokine production protein binding mitochondrion mitochondrial outer membrane peroxisome peroxisomal membrane signal transduction membrane integral component of membrane protein kinase binding mitochondrial membrane positive regulation of type I interferon production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of interferon-beta secretion signaling adaptor activity RIG-I signaling pathway positive regulation of protein import into nucleus defense response to bacterium negative regulation of viral genome replication innate immune response positive regulation of transcription from RNA polymerase II promoter CARD domain binding positive regulation of sequence-specific DNA binding transcription factor activity defense response to virus positive regulation of type I interferon-mediated signaling pathway positive regulation of response to cytokine stimulus cellular response to exogenous dsRNA positive regulation of chemokine (C-C motif) ligand 5 production positive regulation of IP-10 production regulation of peroxisome organization positive regulation of interferon-alpha secretion positive regulation of tumor necrosis factor secretion positive regulation of interleukin-6 secretion uc008mle.1 uc008mle.2 uc008mle.3 uc008mle.4 uc008mle.5 
ENSMUST00000041364.13 Nop14 ENSMUST00000041364.13 NOP14 nucleolar protein (from RefSeq NM_029278.3) ENSMUST00000041364.1 ENSMUST00000041364.10 ENSMUST00000041364.11 ENSMUST00000041364.12 ENSMUST00000041364.2 ENSMUST00000041364.3 ENSMUST00000041364.4 ENSMUST00000041364.5 ENSMUST00000041364.6 ENSMUST00000041364.7 ENSMUST00000041364.8 ENSMUST00000041364.9 NM_029278 NOP14_MOUSE Nol14 Q5RL78 Q8R3N1 uc008xcx.1 uc008xcx.2 Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). Component of the ribosomal small subunit (SSU) processome. Nucleus, nucleolus Belongs to the NOP14 family. nucleus nucleolus rRNA processing enzyme binding snoRNA binding Noc4p-Nop14p complex small-subunit processome ribosome biogenesis ribosomal small subunit biogenesis uc008xcx.1 uc008xcx.2 
ENSMUST00000041366.14 Polr2j ENSMUST00000041366.14 polymerase (RNA) II (DNA directed) polypeptide J (from RefSeq NM_011293.2) ENSMUST00000041366.1 ENSMUST00000041366.10 ENSMUST00000041366.11 ENSMUST00000041366.12 ENSMUST00000041366.13 ENSMUST00000041366.2 ENSMUST00000041366.3 ENSMUST00000041366.4 ENSMUST00000041366.5 ENSMUST00000041366.6 ENSMUST00000041366.7 ENSMUST00000041366.8 ENSMUST00000041366.9 NM_011293 Polr2j Q6PI63 Q6PI63_MOUSE uc008zzw.1 uc008zzw.2 uc008zzw.3 uc008zzw.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft. Nucleus Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family. RNA polymerase II activity DNA binding DNA-directed 5'-3' RNA polymerase activity nucleus DNA-directed RNA polymerase II, core complex transcription, DNA-templated transcription from RNA polymerase II promoter LRR domain binding protein dimerization activity uc008zzw.1 uc008zzw.2 uc008zzw.3 uc008zzw.4 
ENSMUST00000041369.8 Socs5 ENSMUST00000041369.8 suppressor of cytokine signaling 5 (from RefSeq NM_019654.2) Cish5 ENSMUST00000041369.1 ENSMUST00000041369.2 ENSMUST00000041369.3 ENSMUST00000041369.4 ENSMUST00000041369.5 ENSMUST00000041369.6 ENSMUST00000041369.7 NM_019654 O54928 Q7TSK1 SOCS5_MOUSE uc008dup.1 uc008dup.2 uc008dup.3 uc008dup.4 uc008dup.5 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T- helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. Protein modification; protein ubiquitination. Interacts with EGFR. Interacts with ELOB and ELOC; mediates EGFR ubiquitination and degradation (By similarity). Interacts with IL4R; inhibits IL4 signaling. Widely expressed. Expressed in TH1 but not TH2 cells. During embryonic development, expressed from mid- to-late gestation and in yolk sac. By a subset of cytokines including IL6 and LIF. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. Phosphorylated. Phosphorylation is induced by EGF (By similarity). epidermal growth factor receptor binding protein binding cytoplasm phosphatidylinositol 3-kinase complex epidermal growth factor receptor signaling pathway negative regulation of epidermal growth factor-activated receptor activity JAK-STAT cascade negative regulation of signal transduction protein ubiquitination kinase inhibitor activity cytokine-mediated signaling pathway receptor tyrosine kinase binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of interleukin-6 production intracellular signal transduction regulation of growth regulation of phosphatidylinositol 3-kinase activity positive regulation of T-helper 1 cell differentiation negative regulation of T-helper 2 cell differentiation phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity negative regulation of inflammatory response cellular response to low-density lipoprotein particle stimulus negative regulation of monocyte chemotactic protein-1 production vascular endothelial cell response to fluid shear stress negative regulation of endothelial cell activation uc008dup.1 uc008dup.2 uc008dup.3 uc008dup.4 uc008dup.5 
ENSMUST00000041370.11 Txlng ENSMUST00000041370.11 taxilin gamma, transcript variant 1 (from RefSeq NM_178935.5) A2AFJ5 ENSMUST00000041370.1 ENSMUST00000041370.10 ENSMUST00000041370.2 ENSMUST00000041370.3 ENSMUST00000041370.4 ENSMUST00000041370.5 ENSMUST00000041370.6 ENSMUST00000041370.7 ENSMUST00000041370.8 ENSMUST00000041370.9 Lrg NM_178935 Q148Z8 Q2LGB1 Q2PMX1 Q8BHN1 Q8BP11 TXLNG_MOUSE uc009uuh.1 uc009uuh.2 uc009uuh.3 uc009uuh.4 May be involved in intracellular vesicle traffic (By similarity). Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A (By similarity). Forms a heterodimer with ATF4 in osteoblasts. Q8BHN1; Q9UHD2: TBK1; Xeno; NbExp=2; IntAct=EBI-6116854, EBI-356402; Nucleus membrane Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=LrgW; IsoId=Q8BHN1-1; Sequence=Displayed; Name=2; IsoId=Q8BHN1-2; Sequence=VSP_011835, VSP_011836, VSP_011837; Name=3; Synonyms=LrgS; IsoId=Q8BHN1-3; Sequence=VSP_011835; At 16.5 dpc, expressed in osteoblasts surrounding newly formed trabecular bone. At postnatal day 2, detected in most osteoblasts and lining cells, and also strongly expressed in osteocytes. By postnatal week 4, strongly expressed in osteocytes (at protein level). By LPS. Belongs to the taxilin family. Sequence=ABC47035.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=ABC47035.1; Type=Frameshift; Evidence=; Sequence=ABC60327.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=ABC60327.1; Type=Frameshift; Evidence=; protein binding nucleus cytoplasm cytosol cell cycle regulation of cell cycle process membrane syntaxin binding regulation of bone mineralization nuclear membrane protein heterodimerization activity regulation of cell cycle uc009uuh.1 uc009uuh.2 uc009uuh.3 uc009uuh.4 
ENSMUST00000041374.8 Manea ENSMUST00000041374.8 mannosidase, endo-alpha, transcript variant 1 (from RefSeq NM_172865.3) ENSMUST00000041374.1 ENSMUST00000041374.2 ENSMUST00000041374.3 ENSMUST00000041374.4 ENSMUST00000041374.5 ENSMUST00000041374.6 ENSMUST00000041374.7 MANEA_MOUSE NM_172865 Q6NXH2 Q8C0N9 uc008sej.1 uc008sej.2 uc008sej.3 Reaction=H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)- alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man- (1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta- GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] = alpha-D- glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- (1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2); Xref=Rhea:RHEA:54824, Rhea:RHEA- COMP:14010, Rhea:RHEA-COMP:14011, ChEBI:CHEBI:15377, ChEBI:CHEBI:52996, ChEBI:CHEBI:59080, ChEBI:CHEBI:60627; EC=3.2.1.130; Evidence=; Golgi apparatus membrane ; Single-pass type II membrane protein Undergoes proteolytic cleavage in the C-terminal region. Belongs to the glycosyl hydrolase 99 family. Golgi membrane alpha-mannosidase activity glycoprotein endo-alpha-1,2-mannosidase activity Golgi apparatus membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds uc008sej.1 uc008sej.2 uc008sej.3 
ENSMUST00000041377.13 Lyn ENSMUST00000041377.13 LYN proto-oncogene, Src family tyrosine kinase, transcript variant 3 (from RefSeq NR_185264.1) ENSMUST00000041377.1 ENSMUST00000041377.10 ENSMUST00000041377.11 ENSMUST00000041377.12 ENSMUST00000041377.2 ENSMUST00000041377.3 ENSMUST00000041377.4 ENSMUST00000041377.5 ENSMUST00000041377.6 ENSMUST00000041377.7 ENSMUST00000041377.8 ENSMUST00000041377.9 Lyn NR_185264 Q3TCS3 Q3TCS3_MOUSE uc008rwm.1 uc008rwm.2 uc008rwm.3 uc008rwm.4 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Belongs to the protein kinase superfamily. Tyr protein kinase family. nucleotide binding positive regulation of protein phosphorylation histamine secretion by mast cell protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding platelet-derived growth factor receptor binding integrin binding ATP binding nucleus mitochondrial intermembrane space Golgi apparatus plasma membrane cell-cell adherens junction protein phosphorylation cellular response to DNA damage stimulus response to sterol depletion transmembrane receptor protein tyrosine kinase signaling pathway negative regulation of cell proliferation response to toxic substance response to carbohydrate positive regulation of neuron projection development oligodendrocyte development postsynaptic density response to organic cyclic compound membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation enzyme binding mitochondrial crista ubiquitin protein ligase binding cellular response to extracellular stimulus mitochondrial membrane response to insulin regulation of cell adhesion mediated by integrin cellular response to heat integrin alpha2-beta1 complex positive regulation of phosphorylation response to drug mast cell granule gamma-tubulin binding response to amino acid glycosphingolipid binding intracellular membrane-bounded organelle response to peptide hormone ion channel binding macromolecular complex binding membrane raft protein autophosphorylation ephrin receptor binding perinuclear region of cytoplasm response to axon injury cytokine secretion phosphoprotein binding positive regulation of cellular component movement regulation of release of sequestered calcium ion into cytosol positive regulation of glial cell proliferation positive regulation of Fc receptor mediated stimulatory signaling pathway positive regulation of stress-activated protein kinase signaling cascade positive regulation of oligodendrocyte progenitor proliferation positive regulation of mast cell proliferation cellular response to retinoic acid regulation of monocyte chemotaxis glutamatergic synapse postsynaptic specialization, intracellular component positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process uc008rwm.1 uc008rwm.2 uc008rwm.3 uc008rwm.4 
ENSMUST00000041382.7 Fcsk ENSMUST00000041382.7 fucose kinase, transcript variant 1 (from RefSeq NM_172283.3) ENSMUST00000041382.1 ENSMUST00000041382.2 ENSMUST00000041382.3 ENSMUST00000041382.4 ENSMUST00000041382.5 ENSMUST00000041382.6 FCSK_MOUSE Fuk NM_172283 Q7TMC8 Q7TSB1 Q8C7W3 Q8CI18 uc009nlg.1 uc009nlg.2 uc009nlg.3 uc009nlg.4 Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides. [Isoform 1]: Has strong fucokinase activity. [Isoform 2]: Has very weak fucokinase activity. Reaction=ATP + L-fucose = ADP + beta-L-fucose 1-phosphate + H(+); Xref=Rhea:RHEA:13241, ChEBI:CHEBI:2181, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57268, ChEBI:CHEBI:456216; EC=2.7.1.52; Evidence=; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TMC8-1; Sequence=Displayed; Name=2; IsoId=Q7TMC8-2; Sequence=VSP_058365; Isoform 1: Expressed strongly in brain, ovary and testis, moderately in kidney and liver, and weakly in lung, spleen and heart. Isoform 2: Expressed very strongly in brain, strongly in ovary, testis and kidney, moderately in lung and liver, and weakly in heart and spleen. Belongs to the GHMP kinase family. Sequence=AAH37698.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding ATP binding cellular_component kinase activity phosphorylation transferase activity transferase activity, transferring phosphorus-containing groups GDP-L-fucose salvage carbohydrate phosphorylation fucokinase activity response to dopamine uc009nlg.1 uc009nlg.2 uc009nlg.3 uc009nlg.4 
ENSMUST00000041385.14 Arhgap27 ENSMUST00000041385.14 Rho GTPase activating protein 27, transcript variant 2 (from RefSeq NM_133715.5) A2AB59 Camgap1 ENSMUST00000041385.1 ENSMUST00000041385.10 ENSMUST00000041385.11 ENSMUST00000041385.12 ENSMUST00000041385.13 ENSMUST00000041385.2 ENSMUST00000041385.3 ENSMUST00000041385.4 ENSMUST00000041385.5 ENSMUST00000041385.6 ENSMUST00000041385.7 ENSMUST00000041385.8 ENSMUST00000041385.9 NM_133715 Q3V366 Q4V9V5 RHG27_MOUSE uc007lud.1 uc007lud.2 uc007lud.3 uc007lud.4 Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). Interacts with SH3KBP1/CIN85. Cytoplasm Membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AB59-1; Sequence=Displayed; Name=2; IsoId=A2AB59-2; Sequence=VSP_031057; Widely expressed. Highly expressed in kidney, lung, small intestine and thymus. Sequence=AAH96671.1; Type=Erroneous initiation; Evidence=; GTPase activator activity nucleus nucleoplasm cytoplasm endosome cytosol endocytosis receptor-mediated endocytosis signal transduction membrane SH3 domain binding regulation of GTPase activity positive regulation of GTPase activity uc007lud.1 uc007lud.2 uc007lud.3 uc007lud.4 
ENSMUST00000041388.11 Serpine1 ENSMUST00000041388.11 serine (or cysteine) peptidase inhibitor, clade E, member 1 (from RefSeq NM_008871.2) ENSMUST00000041388.1 ENSMUST00000041388.10 ENSMUST00000041388.2 ENSMUST00000041388.3 ENSMUST00000041388.4 ENSMUST00000041388.5 ENSMUST00000041388.6 ENSMUST00000041388.7 ENSMUST00000041388.8 ENSMUST00000041388.9 G5E899 G5E899_MOUSE NM_008871 Serpine1 uc009abn.1 uc009abn.2 uc009abn.3 uc009abn.4 uc009abn.5 Belongs to the serpin family. chronological cell aging angiogenesis protease binding serine-type endopeptidase inhibitor activity receptor binding extracellular region extracellular space regulation of receptor activity negative regulation of plasminogen activation negative regulation of endopeptidase activity negative regulation of smooth muscle cell migration positive regulation of blood coagulation negative regulation of cell migration positive regulation of interleukin-8 production negative regulation of cell adhesion mediated by integrin positive regulation of leukotriene production involved in inflammatory response positive regulation of angiogenesis positive regulation of receptor-mediated endocytosis positive regulation of inflammatory response defense response to Gram-negative bacterium negative regulation of fibrinolysis negative regulation of vascular wound healing extracellular exosome cellular response to lipopolysaccharide positive regulation of monocyte chemotaxis replicative senescence dentinogenesis positive regulation of odontoblast differentiation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of smooth muscle cell-matrix adhesion negative regulation of endothelial cell apoptotic process uc009abn.1 uc009abn.2 uc009abn.3 uc009abn.4 uc009abn.5 
ENSMUST00000041391.5 Psd ENSMUST00000041391.5 pleckstrin and Sec7 domain containing, transcript variant 1 (from RefSeq NM_028627.2) B2RS07 B7ZNN7 ENSMUST00000041391.1 ENSMUST00000041391.2 ENSMUST00000041391.3 ENSMUST00000041391.4 Efa6a Kiaa2011 NM_028627 PSD1_MOUSE Psd1 Q3TY69 Q5DTT2 Q6PE10 uc008htd.1 uc008htd.2 Guanine nucleotide exchange factor for ARF6 (By similarity). Isoform 2 and isoform 3 induce cytoskeletal remodeling, but lead to distinct morphological changes in HeLa cells: isoform 2 induces cell elongation and formation of actin-rich protrusions, whereas isoform 3 promotes the formation of membrane ruffles and loss of stress fibers (PubMed:19494129). Interacts with ACTN1 (PubMed:17298598). Interacts (ARF6-bound form) with KCNK1; does not interact with KCNK1 in the absence of ARF6 (PubMed:15540117). [Isoform 1]: Cell membrane Cell projection, ruffle te=Colocalizes with ACTN1 in membrane ruffles and central reticular structures. [Isoform 2]: Cell membrane Cell projection Note=Accumulates in microvilli-like protrusions. [Isoform 3]: Cell membrane Cell projection, ruffle te=Colocalizes with F-actin in membrane ruffles. Cell membrane Cell projection, ruffle membrane Cleavage furrow Note=Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In later cytokinesis phases, fades away from the cleavage furrow and becomes uniformly distributed throughout the plasma membrane. Event=Alternative promoter usage, Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5DTT2-1; Sequence=Displayed; Name=2; Synonyms=EFA6As; IsoId=Q5DTT2-2; Sequence=VSP_033637, VSP_033638; Name=3; Synonyms=EFA6A; IsoId=Q5DTT2-3; Sequence=VSP_041569; Highest expression detected in brain and some expression detected also in uterus, stomach, ovary and intestine, with isoform 2 being expressed at the highest levels. In the brain, isoform 1 is highly expressed in the strata oriens, radiatum, lacunosum- moleculare of the hippocampal CA1-3 regions and the dentate molecular layer of the hippocampal formation, with lower levels detected in the neuronal cell layers and the stratum lucidum (at protein level). Not detected in tongue, thymus, spleen, lung, heart, liver and kidney. Expressed in embryonic, early postnatal and adult brain, with expression up-regulated at postnatal day 4-8 and down- regulated in adults. Isoform 2 expression is up-regulated in adults. [Isoform 2]: Produced by alternative promoter usage. [Isoform 3]: Produced by alternative splicing of isoform 1. Belongs to the PSD family. ruffle guanyl-nucleotide exchange factor activity ARF guanyl-nucleotide exchange factor activity protein binding phospholipid binding plasma membrane postsynaptic density membrane integral component of membrane neuron projection development regulation of ARF protein signal transduction cleavage furrow ruffle membrane cell projection dendritic spine extrinsic component of postsynaptic endosome membrane postsynaptic density, intracellular component uc008htd.1 uc008htd.2 
ENSMUST00000041398.5 H2-M10.6 ENSMUST00000041398.5 histocompatibility 2, M region locus 10.6 (from RefSeq NM_201611.2) ENSMUST00000041398.1 ENSMUST00000041398.2 ENSMUST00000041398.3 ENSMUST00000041398.4 H2-M10.6 NM_201611 Q85ZW5 Q85ZW5_MOUSE uc008clf.1 uc008clf.2 uc008clf.3 uc008clf.4 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc008clf.1 uc008clf.2 uc008clf.3 uc008clf.4 
ENSMUST00000041401.11 Herc3 ENSMUST00000041401.11 hect domain and RLD 3, transcript variant 2 (from RefSeq NM_028705.3) A6H6S0 A6H6S0_MOUSE ENSMUST00000041401.1 ENSMUST00000041401.10 ENSMUST00000041401.2 ENSMUST00000041401.3 ENSMUST00000041401.4 ENSMUST00000041401.5 ENSMUST00000041401.6 ENSMUST00000041401.7 ENSMUST00000041401.8 ENSMUST00000041401.9 Herc3 NM_028705 uc009cdf.1 uc009cdf.2 uc009cdf.3 ubiquitin-protein transferase activity cytosol protein ubiquitination transferase activity uc009cdf.1 uc009cdf.2 uc009cdf.3 
ENSMUST00000041407.7 Sostdc1 ENSMUST00000041407.7 sclerostin domain containing 1 (from RefSeq NM_025312.3) ENSMUST00000041407.1 ENSMUST00000041407.2 ENSMUST00000041407.3 ENSMUST00000041407.4 ENSMUST00000041407.5 ENSMUST00000041407.6 NM_025312 Q8CF09 Q9CQN4 SOSD1_MOUSE Sostl Usag1 uc007njx.1 uc007njx.2 uc007njx.3 uc007njx.4 May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. Interacts with BMP2, BMP4, BMP6 and BMP7 with high affinity. Secreted Highly expressed in kidney at renal collecting ducts level and weakly in brain. Expression was first detected at 11 dpc throughout the surface of the embryo, and it was most intense in the head region on the surfaces of the mandibular, maxillary, and frontonasal processes. At 11.5 dpc expression is detected in the first and second branchial arches, pharynx and metanephros. At 12 dpc-14 dpc, expression was intense and strikingly confined to developing ectodermal organs. The vibrissae, tylotrich hair follicles, tongue papillae, and tooth germs as well as the ear auricle. Also expressed intensely in kidney epithelium in the stalk and tips of ureter as well as in the spermatic ducts in the testis. At 17.5 dpc strong expression was restricted to kidney tubules and ameloblasts in teeth, and moderate expression was observed in hair follicles, choroids plexus of the fourth cerebral ventricle of the brain. First detected on 12.5 dpc in interstitial cell of the testis and increased towards 14.5 dpc. On 8 dpp (day post partum) highly expression was detected in kidney and weakly in skin. Up-regulated by BMP2 and BMP7. Down-regulated by FGF4 and SHH. Belongs to the sclerostin family. protein binding extracellular region extracellular space pattern specification process negative regulation of cell fate commitment Wnt signaling pathway negative regulation of Wnt signaling pathway BMP signaling pathway negative regulation of BMP signaling pathway hair follicle morphogenesis BMP binding odontogenesis of dentin-containing tooth negative regulation of myoblast differentiation mammary gland bud morphogenesis negative regulation of canonical Wnt signaling pathway BMP receptor activity negative regulation of determination of dorsal identity uc007njx.1 uc007njx.2 uc007njx.3 uc007njx.4 
ENSMUST00000041415.5 Kcnh3 ENSMUST00000041415.5 potassium voltage-gated channel, subfamily H (eag-related), member 3 (from RefSeq NM_010601.4) B2RU85 E9QMZ8 ENSMUST00000041415.1 ENSMUST00000041415.2 ENSMUST00000041415.3 ENSMUST00000041415.4 Elk2 KCNH3_MOUSE NM_010601 Q6U1M1 Q9WVJ0 uc011zzc.1 uc011zzc.2 uc011zzc.3 The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. An increase in cognitive function was observed when this gene was knocked out, while deletion of the gene resulted in hippocampal hyperexcitability and epilepsy. [provided by RefSeq, Sep 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC141013.1, SRR1660813.131441.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Membrane; Multi-pass membrane protein. Detected in brain, but not in other tissues. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity integral component of plasma membrane ion transport potassium ion transport membrane integral component of membrane regulation of ion transmembrane transport regulation of membrane potential transmembrane transport potassium ion transmembrane transport uc011zzc.1 uc011zzc.2 uc011zzc.3 
ENSMUST00000041416.8 Vnn1 ENSMUST00000041416.8 vanin 1 (from RefSeq NM_011704.3) ENSMUST00000041416.1 ENSMUST00000041416.2 ENSMUST00000041416.3 ENSMUST00000041416.4 ENSMUST00000041416.5 ENSMUST00000041416.6 ENSMUST00000041416.7 NM_011704 Q3TJI0 Q8VCT1 Q9DCH8 Q9Z0K8 VNN1_MOUSE uc007eqc.1 uc007eqc.2 uc007eqc.3 Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Reaction=(R)-pantetheine + H2O = (R)-pantothenate + cysteamine; Xref=Rhea:RHEA:13445, ChEBI:CHEBI:15377, ChEBI:CHEBI:16753, ChEBI:CHEBI:29032, ChEBI:CHEBI:58029; EC=3.5.1.92; Evidence=; Monomer. Cell membrane ipid-anchor, GPI-anchor Detected in kidney (at protein level). Ubiquitous. N-glycosylated. No visible phenotype. Mice lack detectable levels of cysteamine in liver and kidney. Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. acute inflammatory response chronic inflammatory response plasma membrane nitrogen compound metabolic process inflammatory response pantothenate metabolic process membrane integral component of membrane hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides pantetheine hydrolase activity anchored component of membrane positive regulation of T cell differentiation in thymus GPI anchor binding innate immune response cell-cell adhesion negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway extracellular space uc007eqc.1 uc007eqc.2 uc007eqc.3 
ENSMUST00000041438.7 Sesn1 ENSMUST00000041438.7 sestrin 1, transcript variant 2 (from RefSeq NM_001013370.2) E9QPK0 ENSMUST00000041438.1 ENSMUST00000041438.2 ENSMUST00000041438.3 ENSMUST00000041438.4 ENSMUST00000041438.5 ENSMUST00000041438.6 NM_001013370 P58006 Pa26 Q7TNF3 SESN1_MOUSE Sesn1 Sest1 uc007eyf.1 uc007eyf.2 uc007eyf.3 uc007eyf.4 Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25259925). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed (By similarity). Reaction=a hydroperoxide + L-cysteinyl-[protein] = an alcohol + S- hydroxy-L-cysteinyl-[protein]; Xref=Rhea:RHEA:67124, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:17193, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:61973; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67125; Evidence=; Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by leucine (By similarity). Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them (PubMed:25259925). Interacts with KEAP1, RBX1 and SQSTM1; in the SQSTM1-dependent autophagic degradation of KEAP1. May interact with PRDX1 (By similarity). Nucleus Cytoplasm Highly expressed in heart and also detected in liver and skeletal muscles (at protein level). The N-terminal domain may have an alkylhydroperoxide reductase activity. The C-terminal domain mediates interaction with GATOR2 through which it regulates TORC1 signaling. Triple knockout mice lacking Sesn1, Sesn2 and Sesn3 do not display an embryonic lethal phenotype since they are born at an expected Mendelian ratio. Moreover, they are not distinguishable from their wild-type littermates. However, their survival at 10 days is dramatically affected. This is associated with a constitutive activation of TORC1 signaling in the liver, heart and skeletal muscle during postnatal fasting, that occurs between birth and suckling. Belongs to the sestrin family. fibrillar center protein binding nucleus cytoplasm positive regulation of macroautophagy oxidoreductase activity oxidoreductase activity, acting on peroxide as acceptor negative regulation of cell growth cellular response to amino acid starvation cellular response to glucose starvation regulation of protein kinase B signaling peroxiredoxin activity oxidation-reduction process leucine binding cellular response to amino acid stimulus cellular response to leucine reactive oxygen species metabolic process cellular oxidant detoxification regulation of response to reactive oxygen species negative regulation of TORC1 signaling cellular response to leucine starvation TORC2 complex GATOR2 complex uc007eyf.1 uc007eyf.2 uc007eyf.3 uc007eyf.4 
ENSMUST00000041447.5 Trpa1 ENSMUST00000041447.5 transient receptor potential cation channel, subfamily A, member 1, transcript variant 1 (from RefSeq NM_177781.5) Anktm1 ENSMUST00000041447.1 ENSMUST00000041447.2 ENSMUST00000041447.3 ENSMUST00000041447.4 NM_177781 Q0VBN5 Q8BLA8 TRPA1_MOUSE Trpa1 uc007ajc.1 uc007ajc.2 Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:24140646). Shows 8-fold preference for divalent over monovalent cations. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of irritants, such as allylthiocyanate (AITC) found in mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an irritant from tears gas and vehicle exhaust fumes (PubMed:16564016). Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. A cytosolic factor (probably pyrophosphate, polytriphosphate, polyP4, polyP25, polyP45, and/or polyP65) is necessary for TRPA1 activation by irritants (PubMed:17567811). Such factor acts by keeping TRPA1 in a agonist-sensitive state (PubMed:17567811). Inhibited by the potent blocker of TRPV channels ruthenium red, A-967079 (PubMed:15843607, PubMed:29703838, PubMed:31447178). Activated by icilin, sulfhydryl reactive agent MTSEA, N-methyl maleimide (NMM), and PF-4840154 (PubMed:17237762, PubMed:29703838). Homotetramer (PubMed:21908607). Interacts with TMEM100 (PubMed:25640077). Interacts with EGLN1 (PubMed:21873995). Interacts with the scorpion wasabi receptor toxin at the same site that electrophiles but in a non-covalent manner (By similarity). Cell membrane ulti-pass membrane protein Expressed in inner ear (at protein level). Specifically expressed in a subset of nociceptive neurons. Expressed in the same neurons that TRPV1. In contrast, it is not expressed in neurons expressing TRPM8. Expressed in the superior cervical ganglion of vagus nerve. Expressed in the inferior ganglion (nodose ganglion) of vagus nerve (PubMed:21873995). Expressed in dorsal root ganglia neurons (PubMed:21873995). During utricle development, it is first expressed at 15 dpc and 16 dpc and peaks at 17 dpc. It drops at 18 dpc but increases again at 19 dpc, possibly corresponding to a second wave of hair cells that are generated at 15 dpc. C-terminal helices from the four subunits associate to form atypical coiled coil structure; this region is probably involved in binding the inositol polyphosphates that are required for optimal channel activity (in vitro). The ANK repeat domain consists of a convex stem structure followed by a crescent-shaped structure that surrounds the protein core. TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the N-terminal cytoplasmic domain (PubMed:17237762, PubMed:22207754). Hydroxylation is required for TRPA1 activity inhibition in normoxia. In hypoxia, the decrease in oxygen concentration diminishes the activity of the hydroxylase EGLN1, thus relieving TRPA1 from inhibition and ultimately leading to channel activation. Oxidation of Cys-634 and Cys-859 in hyperoxia may override the hydroxylase EGLN1-mediated inhibition, causing TRPA1 activation. Mice display normal cold sensitivity and unimpaired auditory function, suggesting that this channel is not required for the initial detection of noxious cold or sound. However, they exhibit pronounced deficits in bradykinin-evoked nociceptor excitation and pain hypersensitivity. Belongs to the transient receptor (TC 1.A.4) family. Name=Protein Spotlight; Note=The power behind pain - Issue 82 of May 2007; URL="https://web.expasy.org/spotlight/back_issues/082"; ion channel activity voltage-gated calcium channel activity calcium channel activity protein binding plasma membrane integral component of plasma membrane ion transport calcium ion transport cell surface receptor signaling pathway response to cold response to organic substance response to organic cyclic compound urinary bladder smooth muscle contraction channel activity calcium-release channel activity membrane integral component of membrane apical plasma membrane sensory perception of pain axon stereocilium bundle cellular response to heat positive regulation of insulin secretion involved in cellular response to glucose stimulus response to drug response to hydrogen peroxide identical protein binding response to pain response to stimulus thermoception detection of mechanical stimulus involved in sensory perception of pain detection of chemical stimulus involved in sensory perception of pain release of sequestered calcium ion into cytosol protein homotetramerization transmembrane transport cellular response to cold calcium ion transmembrane transport cellular response to carbon dioxide calcium ion transmembrane import into cytosol temperature-gated cation channel activity regulation of neuronal action potential regulation of blood circulation positive regulation of anion transport positive regulation of sensory perception of pain osmolarity-sensing cation channel activity uc007ajc.1 uc007ajc.2 
ENSMUST00000041459.9 Cyb561d2 ENSMUST00000041459.9 cytochrome b-561 domain containing 2, transcript variant 1 (from RefSeq NM_019720.4) 101f6 C56D2_MOUSE Cyb561d2 ENSMUST00000041459.1 ENSMUST00000041459.2 ENSMUST00000041459.3 ENSMUST00000041459.4 ENSMUST00000041459.5 ENSMUST00000041459.6 ENSMUST00000041459.7 ENSMUST00000041459.8 NM_019720 Q3TRQ1 Q9WUE3 uc009rll.1 uc009rll.2 uc009rll.3 Transmembrane reductase that may use ascorbate as an electron donor in the cytoplasm and transfer electrons across endoplasmic reticulum membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in the lumen of that compartment. Reaction=L-ascorbate(in) + monodehydro-L-ascorbate radical(out) = L- ascorbate(out) + monodehydro-L-ascorbate radical(in); Xref=Rhea:RHEA:66524, ChEBI:CHEBI:38290, ChEBI:CHEBI:59513; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66525; Evidence=; Reaction=Fe(3+)(out) + L-ascorbate(in) = Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in); Xref=Rhea:RHEA:30403, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:38290, ChEBI:CHEBI:59513; EC=7.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30404; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 2 heme b groups non-covalently. ; Redox potential: E(0) is +141 +/-9 mV for the high potential heme and +43 +/-9 mV for the low potential heme. ; Endoplasmic reticulum membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Highly expressed in the brain, lung, liver, and kidney (PubMed:17938141). Moderately expressed in the heart, placenta, skeletal muscle, and pancreas (PubMed:17938141). ferroxidase activity endoplasmic reticulum endoplasmic reticulum membrane biological_process membrane integral component of membrane heme binding cytoplasmic vesicle membrane cytoplasmic vesicle vesicle metal ion binding oxidation-reduction process uc009rll.1 uc009rll.2 uc009rll.3 
ENSMUST00000041463.7 Pacrg ENSMUST00000041463.7 PARK2 co-regulated (from RefSeq NM_027032.2) ENSMUST00000041463.1 ENSMUST00000041463.2 ENSMUST00000041463.3 ENSMUST00000041463.4 ENSMUST00000041463.5 ENSMUST00000041463.6 NM_027032 PACRG_MOUSE Q7TPF9 Q8CG20 Q9DAK2 uc008akg.1 uc008akg.2 uc008akg.3 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease (By similarity). Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components. Interacts with STIP1, PRKN, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7 and CCT8 (By similarity). Interacts with MEIG1. Q9DAK2; Q61845: Meig1; NbExp=3; IntAct=EBI-8572392, EBI-15805257; Cytoplasm, cytoskeleton, cilium axoneme G-protein coupled receptor binding actin binding protein binding mitochondrion cytosol cilium spermatid development Hsp70 protein binding heat shock protein binding ubiquitin protein ligase binding vesicle cellular response to unfolded protein neuron projection alpha-tubulin binding cell body beta-tubulin binding chaperone binding Hsp90 protein binding negative regulation of cell death sperm midpiece uc008akg.1 uc008akg.2 uc008akg.3 
ENSMUST00000041466.14 Zbed5 ENSMUST00000041466.14 zinc finger BED-type containing 5, transcript variant 1 (from RefSeq NM_183088.2) 2410018M08Rik B2RPU8 B2RPU8_MOUSE Chchd2l ENSMUST00000041466.1 ENSMUST00000041466.10 ENSMUST00000041466.11 ENSMUST00000041466.12 ENSMUST00000041466.13 ENSMUST00000041466.2 ENSMUST00000041466.3 ENSMUST00000041466.4 ENSMUST00000041466.5 ENSMUST00000041466.6 ENSMUST00000041466.7 ENSMUST00000041466.8 ENSMUST00000041466.9 NM_183088 Scand3 Zbed5 uc008zto.1 uc008zto.2 uc008zto.3 nucleoplasm mitochondrion biological_process uc008zto.1 uc008zto.2 uc008zto.3 
ENSMUST00000041477.15 Islr ENSMUST00000041477.15 immunoglobulin superfamily containing leucine-rich repeat, transcript variant 1 (from RefSeq NM_012043.4) ENSMUST00000041477.1 ENSMUST00000041477.10 ENSMUST00000041477.11 ENSMUST00000041477.12 ENSMUST00000041477.13 ENSMUST00000041477.14 ENSMUST00000041477.2 ENSMUST00000041477.3 ENSMUST00000041477.4 ENSMUST00000041477.5 ENSMUST00000041477.6 ENSMUST00000041477.7 ENSMUST00000041477.8 ENSMUST00000041477.9 ISLR_MOUSE NM_012043 Q6GU68 uc009pwk.1 uc009pwk.2 uc009pwk.3 uc009pwk.4 Secreted Detected in thyroid, heart, retina and spinal cord. Detected at all stages of development and more abundant in the latter period. extracellular region extracellular space uc009pwk.1 uc009pwk.2 uc009pwk.3 uc009pwk.4 
ENSMUST00000041500.8 Srxn1 ENSMUST00000041500.8 sulfiredoxin 1 homolog (S. cerevisiae) (from RefSeq NM_029688.5) A2AQU8 A2AQU8_MOUSE ENSMUST00000041500.1 ENSMUST00000041500.2 ENSMUST00000041500.3 ENSMUST00000041500.4 ENSMUST00000041500.5 ENSMUST00000041500.6 ENSMUST00000041500.7 NM_029688 Srxn1 uc008new.1 uc008new.2 uc008new.3 Reaction=[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl- [peroxiredoxin] = [protein]-disulfide + ADP + phosphate + S-hydroxy- L-cysteinyl-[peroxiredoxin]; Xref=Rhea:RHEA:17545, Rhea:RHEA- COMP:10593, Rhea:RHEA-COMP:10594, Rhea:RHEA-COMP:13681, Rhea:RHEA- COMP:17976, ChEBI:CHEBI:29950, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:50058, ChEBI:CHEBI:61973, ChEBI:CHEBI:61974, ChEBI:CHEBI:456216; EC=1.8.98.2; Evidence=; Belongs to the sulfiredoxin family. nucleotide binding ATP binding cytosol response to oxidative stress antioxidant activity oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors sulfiredoxin activity oxidation-reduction process cellular oxidant detoxification uc008new.1 uc008new.2 uc008new.3 
ENSMUST00000041516.9 Epgn ENSMUST00000041516.9 epithelial mitogen (from RefSeq NM_053087.2) ENSMUST00000041516.1 ENSMUST00000041516.2 ENSMUST00000041516.3 ENSMUST00000041516.4 ENSMUST00000041516.5 ENSMUST00000041516.6 ENSMUST00000041516.7 ENSMUST00000041516.8 EPGN_MOUSE NM_053087 Q8CEX5 Q924X1 uc008ybq.1 uc008ybq.2 uc008ybq.3 Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. Membrane ; Single-pass type I membrane protein Expressed at low levels in testis, heart and liver. MAPK cascade activation of MAPK activity angiogenesis epidermal growth factor receptor binding extracellular space integral component of plasma membrane epidermal growth factor receptor signaling pathway growth factor activity positive regulation of cell proliferation membrane integral component of membrane positive regulation of MAP kinase activity positive regulation of epidermal growth factor-activated receptor activity positive regulation of mitotic nuclear division positive regulation of epithelial cell proliferation uc008ybq.1 uc008ybq.2 uc008ybq.3 
ENSMUST00000041524.11 Trmt13 ENSMUST00000041524.11 tRNA methyltransferase 13, transcript variant 1 (from RefSeq NM_030016.3) Ccdc76 ENSMUST00000041524.1 ENSMUST00000041524.10 ENSMUST00000041524.2 ENSMUST00000041524.3 ENSMUST00000041524.4 ENSMUST00000041524.5 ENSMUST00000041524.6 ENSMUST00000041524.7 ENSMUST00000041524.8 ENSMUST00000041524.9 NM_030016 Q8BYH3 TRM13_MOUSE uc008rck.1 uc008rck.2 uc008rck.3 tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). Reaction=cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O- methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:32767, Rhea:RHEA-COMP:10397, Rhea:RHEA-COMP:10398, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74495, ChEBI:CHEBI:82748; EC=2.1.1.225; Evidence=; Reaction=cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'- O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:43192, Rhea:RHEA-COMP:10399, Rhea:RHEA- COMP:10400, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74495, ChEBI:CHEBI:82748; EC=2.1.1.225; Evidence=; Reaction=adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O- methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43196, Rhea:RHEA-COMP:10401, Rhea:RHEA-COMP:10402, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74477; EC=2.1.1.225; Evidence=; Belongs to the methyltransferase TRM13 family. cellular_component tRNA processing methyltransferase activity transferase activity tRNA methylation methylation metal ion binding uc008rck.1 uc008rck.2 uc008rck.3 
ENSMUST00000041531.7 H2-M10.5 ENSMUST00000041531.7 histocompatibility 2, M region locus 10.5 (from RefSeq NM_177637.3) ENSMUST00000041531.1 ENSMUST00000041531.2 ENSMUST00000041531.3 ENSMUST00000041531.4 ENSMUST00000041531.5 ENSMUST00000041531.6 H2-M10.5 NM_177637 Q85ZW7 Q85ZW7_MOUSE uc008cle.1 uc008cle.2 uc008cle.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc008cle.1 uc008cle.2 uc008cle.3 
ENSMUST00000041537.7 Pate12 ENSMUST00000041537.7 prostate and testis expressed 12 (from RefSeq NM_001167586.2) D3YX25 D3YX25_MOUSE ENSMUST00000041537.1 ENSMUST00000041537.2 ENSMUST00000041537.3 ENSMUST00000041537.4 ENSMUST00000041537.5 ENSMUST00000041537.6 Gm7257 NM_001167586 Pate12 uc012gqu.1 uc012gqu.2 molecular_function cellular_component biological_process uc012gqu.1 uc012gqu.2 
ENSMUST00000041544.8 Fbln2 ENSMUST00000041544.8 fibulin 2, transcript variant 1 (from RefSeq NM_007992.3) ENSMUST00000041544.1 ENSMUST00000041544.2 ENSMUST00000041544.3 ENSMUST00000041544.4 ENSMUST00000041544.5 ENSMUST00000041544.6 ENSMUST00000041544.7 FBLN2_MOUSE G5E8B3 NM_007992 P37889 Q9WUI2 uc009cxw.1 uc009cxw.2 uc009cxw.3 Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN. Homotrimer; disulfide-linked. Interacts with LAMA2 (PubMed:10022829). Interacts with FBN1 (via N-terminal domain). Forms a ternary complex with ELN and FBN1 (By similarity). P37889-1; Q62406-1: Irak1; NbExp=10; IntAct=EBI-645953, EBI-488313; Secreted, extracellular space, extracellular matrix. Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P37889-1; Sequence=Displayed; Name=2; Synonyms=EGF3-less; IsoId=P37889-2; Sequence=VSP_001391; Component of both basement membranes and other connective tissues. The differential expression of the fibulin family contributes to the formation of molecularly distinct extracellular matrices already during early developmental stages of a large number of tissues. Glucocorticoids suppressed mRNA expression and protein synthesis. Belongs to the fibulin family. extracellular matrix structural constituent calcium ion binding protein binding extracellular region extracellular space positive regulation of cell-substrate adhesion extracellular matrix organization extracellular matrix binding uc009cxw.1 uc009cxw.2 uc009cxw.3 
ENSMUST00000041550.12 Mgl2 ENSMUST00000041550.12 macrophage galactose N-acetyl-galactosamine specific lectin 2 (from RefSeq NM_145137.2) ENSMUST00000041550.1 ENSMUST00000041550.10 ENSMUST00000041550.11 ENSMUST00000041550.2 ENSMUST00000041550.3 ENSMUST00000041550.4 ENSMUST00000041550.5 ENSMUST00000041550.6 ENSMUST00000041550.7 ENSMUST00000041550.8 ENSMUST00000041550.9 Mgl2 NM_145137 Q8JZN1 Q8JZN1_MOUSE uc007jtu.1 uc007jtu.2 uc007jtu.3 membrane integral component of membrane carbohydrate binding uc007jtu.1 uc007jtu.2 uc007jtu.3 
ENSMUST00000041551.9 Aagab ENSMUST00000041551.9 alpha- and gamma-adaptin binding protein, transcript variant 3 (from RefSeq NR_151671.1) AAGAB_MOUSE ENSMUST00000041551.1 ENSMUST00000041551.2 ENSMUST00000041551.3 ENSMUST00000041551.4 ENSMUST00000041551.5 ENSMUST00000041551.6 ENSMUST00000041551.7 ENSMUST00000041551.8 NR_151671 Q3TW04 Q8R2R3 Q9CV78 uc009qbf.1 uc009qbf.2 uc009qbf.3 May be involved in endocytic recycling of growth factor receptors such as EGFR. Associated with AP-1 and AP-2 complexes. Cytoplasm, cytosol molecular_function cytoplasm cytosol biological_process protein transport nuclear speck uc009qbf.1 uc009qbf.2 uc009qbf.3 
ENSMUST00000041555.10 Mvb12b ENSMUST00000041555.10 multivesicular body subunit 12B (from RefSeq NM_175184.4) A2ARF1 ENSMUST00000041555.1 ENSMUST00000041555.2 ENSMUST00000041555.3 ENSMUST00000041555.4 ENSMUST00000041555.5 ENSMUST00000041555.6 ENSMUST00000041555.7 ENSMUST00000041555.8 ENSMUST00000041555.9 Fam125b MB12B_MOUSE NM_175184 Q6KAU4 Q6PB42 uc008jib.1 uc008jib.2 uc008jib.3 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity). Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS28. Interacts with VPS37B; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37C; the association appears to be mediated by the TSG101-VPS37 binary subcomplex (By similarity). Endosome Late endosome membrane ; Peripheral membrane protein Belongs to the MVB12 family. Sequence=BAD21363.1; Type=Erroneous initiation; Evidence=; ESCRT I complex nucleus endosome early endosome late endosome cytosol plasma membrane lipid binding protein transport membrane virus maturation late endosome membrane vesicle regulation of epidermal growth factor receptor signaling pathway viral budding uc008jib.1 uc008jib.2 uc008jib.3 
ENSMUST00000041558.15 Ep400 ENSMUST00000041558.15 E1A binding protein p400, transcript variant 1 (from RefSeq NM_029337.2) E9QKV1 ENSMUST00000041558.1 ENSMUST00000041558.10 ENSMUST00000041558.11 ENSMUST00000041558.12 ENSMUST00000041558.13 ENSMUST00000041558.14 ENSMUST00000041558.2 ENSMUST00000041558.3 ENSMUST00000041558.4 ENSMUST00000041558.5 ENSMUST00000041558.6 ENSMUST00000041558.7 ENSMUST00000041558.8 ENSMUST00000041558.9 EP400_MOUSE Kiaa1498 NM_029337 Q3TPY1 Q5RKN8 Q80TC8 Q8BXI5 Q8BYW3 Q8C0P6 Q8CHI7 Q8CHI8 Q8VDF4 Q9DA54 uc008yrg.1 uc008yrg.2 uc008yrg.3 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Regulates transcriptional activity of ZNF42. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. May also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. The NuA4 complex interacts with MYC. EP400 interacts with TRRAP, RUVBL1 and RUVBL2. Component of a SWR1-like complex (By similarity). Interacts with ZNF42. Interacts with PHF5A. Nucleus Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8CHI8-1; Sequence=Displayed; Name=2; IsoId=Q8CHI8-2; Sequence=VSP_011996; Name=3; IsoId=Q8CHI8-3; Sequence=VSP_011996, VSP_011997; Name=4; IsoId=Q8CHI8-4; Sequence=VSP_011998; Name=5; IsoId=Q8CHI8-5; Sequence=VSP_017127, VSP_011998; Expressed in brain, thymus, lung, liver, spleen, kidney, colon and bone marrow. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. Sequence=BAB24439.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAC26781.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAC32913.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding Swr1 complex DNA binding chromatin binding helicase activity protein binding ATP binding nucleus chromatin organization nuclear speck hydrolase activity NuA4 histone acetyltransferase complex histone H4 acetylation histone H2A acetylation protein antigen binding uc008yrg.1 uc008yrg.2 uc008yrg.3 
ENSMUST00000041565.11 Ift172 ENSMUST00000041565.11 intraflagellar transport 172 (from RefSeq NM_026298.5) ENSMUST00000041565.1 ENSMUST00000041565.10 ENSMUST00000041565.2 ENSMUST00000041565.3 ENSMUST00000041565.4 ENSMUST00000041565.5 ENSMUST00000041565.6 ENSMUST00000041565.7 ENSMUST00000041565.8 ENSMUST00000041565.9 IF172_MOUSE Kiaa1179 NM_026298 Q6NZK1 Q6VH22 Q80TI4 Q80W19 Q9DAB0 Wim uc008wyb.1 uc008wyb.2 uc008wyb.3 Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway. Interacts with IFT88 (PubMed:11062270). Interacts with IFT57 (PubMed:23810713). Interacts with RABL2/RABL2A; binds preferentially to GDP-bound RABL2 (PubMed:23055941). Cell projection, cilium Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6VH22-1; Sequence=Displayed; Name=2; IsoId=Q6VH22-2; Sequence=VSP_032850; Co-localizes with RABL2/RABL2A in the midpiece of elongated spermatids within the testis (at protein level). Expressed in the flagellum of elongated spermatids and sperm in the testis lumen (at protein level) (PubMed:24339785). Belongs to the IFT172 family. Sequence=BAC65743.3; Type=Miscellaneous discrepancy; Note=Intron retention. The sequence is a pre-RNA and intronic sequences remain.; Evidence=; negative regulation of transcription from RNA polymerase II promoter neural tube formation neural tube closure heart looping protein binding nucleus cilium axoneme Notch signaling pathway smoothened signaling pathway multicellular organism development determination of left/right symmetry brain development heart development transcription factor binding epidermis development regulation of smoothened signaling pathway dorsal/ventral pattern formation protein processing spinal cord motor neuron differentiation neural tube development intraciliary transport particle B cytoplasmic microtubule organization motile cilium ciliary basal body intraciliary transport cell projection positive regulation of smoothened signaling pathway negative regulation of epithelial cell proliferation palate development limb development cilium assembly bone development hindgut development left/right axis specification sperm midpiece sperm principal piece sperm cytoplasmic droplet non-motile cilium assembly uc008wyb.1 uc008wyb.2 uc008wyb.3 
ENSMUST00000041569.5 Ccdc113 ENSMUST00000041569.5 coiled-coil domain containing 113 (from RefSeq NM_172914.2) CC113_MOUSE ENSMUST00000041569.1 ENSMUST00000041569.2 ENSMUST00000041569.3 ENSMUST00000041569.4 NM_172914 Q8C5T8 uc009myn.1 uc009myn.2 uc009myn.3 Component of centriolar satellites contributing to primary cilium formation. Interacts with HAP1 and PCM1. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Note=Colocalized with HAP1 at centriolar satellites. Centriolar satellite localization requires PCM1. molecular_function nucleoplasm cytoplasm microtubule organizing center cytosol cytoskeleton cell projection organization macromolecular complex centriolar satellite cilium assembly uc009myn.1 uc009myn.2 uc009myn.3 
ENSMUST00000041577.13 Bank1 ENSMUST00000041577.13 B cell scaffold protein with ankyrin repeats 1, transcript variant 1 (from RefSeq NM_001033350.3) BANK1_MOUSE E9QMV3 ENSMUST00000041577.1 ENSMUST00000041577.10 ENSMUST00000041577.11 ENSMUST00000041577.12 ENSMUST00000041577.2 ENSMUST00000041577.3 ENSMUST00000041577.4 ENSMUST00000041577.5 ENSMUST00000041577.6 ENSMUST00000041577.7 ENSMUST00000041577.8 ENSMUST00000041577.9 NM_001033350 Q3U178 Q80VH0 Q8BRV6 Q8BRY8 uc008rmd.1 uc008rmd.2 uc008rmd.3 uc008rmd.4 Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2 (By similarity). Interacts with LYN, ITPR1 and ITPR2. Q80VH0; P42227: Stat3; NbExp=4; IntAct=EBI-646949, EBI-602878; Specifically expressed in spleen. Highly expressed in immature B-cells and recirculating B-cells, and at low levels in pro-B and pre-B cells. Phosphorylated on tyrosines upon BCR activation. Sequence=AAO13613.1; Type=Erroneous initiation; Evidence=; Sequence=BAE33622.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAE33622.1; Type=Frameshift; Evidence=; receptor binding protein binding cellular_component response to bacterium B cell activation positive regulation of MAPK cascade negative regulation of translational initiation positive regulation of peptidyl-tyrosine phosphorylation negative regulation of B cell activation negative regulation of protein kinase B signaling negative regulation of interleukin-6 secretion protein tyrosine kinase binding uc008rmd.1 uc008rmd.2 uc008rmd.3 uc008rmd.4 
ENSMUST00000041582.15 Snx25 ENSMUST00000041582.15 sorting nexin 25, transcript variant 3 (from RefSeq NM_207213.3) E9QMG5 ENSMUST00000041582.1 ENSMUST00000041582.10 ENSMUST00000041582.11 ENSMUST00000041582.12 ENSMUST00000041582.13 ENSMUST00000041582.14 ENSMUST00000041582.2 ENSMUST00000041582.3 ENSMUST00000041582.4 ENSMUST00000041582.5 ENSMUST00000041582.6 ENSMUST00000041582.7 ENSMUST00000041582.8 ENSMUST00000041582.9 NM_207213 Q3ZT31 Q6PGF1 SNX25_MOUSE uc291zqz.1 uc291zqz.2 May be involved in several stages of intracellular trafficking. Endosome membrane ; Peripheral membrane protein Belongs to the sorting nexin family. Sequence=AAT98626.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; endosome endosome membrane protein transport membrane negative regulation of transforming growth factor beta receptor signaling pathway receptor catabolic process type I transforming growth factor beta receptor binding phosphatidylinositol binding intracellular membrane-bounded organelle negative regulation of pathway-restricted SMAD protein phosphorylation uc291zqz.1 uc291zqz.2 
ENSMUST00000041587.8 Gga1 ENSMUST00000041587.8 golgi associated, gamma adaptin ear containing, ARF binding protein 1 (from RefSeq NM_145929.2) ENSMUST00000041587.1 ENSMUST00000041587.2 ENSMUST00000041587.3 ENSMUST00000041587.4 ENSMUST00000041587.5 ENSMUST00000041587.6 ENSMUST00000041587.7 GGA1_MOUSE NM_145929 Q3U2N1 Q8R0H9 uc007wrn.1 uc007wrn.2 uc007wrn.3 Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes (PubMed:25405894). Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface (By similarity). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (PubMed:25405894). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (By similarity). Monomer. Interacts with GGA2 and GGA3 (By similarity). Binds to clathrin and activated ARFs, including ARF1, ARF5 and ARF6 (PubMed:22522702, PubMed:11950392). Interacts with RABEP1 and RABGEF1 (PubMed:25405894). Interacts with the type-I membrane proteins LRP3, M6PR/CD-MPR and IGF2R/CI-MPR. Interacts (via N-terminal VHS domain) with SORL1/sorLA and SORT1 (via C-terminal cytosolic domain) (By similarity). Interacts with EPN4. Interacts with CCDC91 (By similarity). Interacts with HEATR5B/p200a (By similarity). Interacts with SYNRG/gamma-synergin (By similarity). Interacts (via GAE doamin) with NECAP1 and NECAP2 (By similarity). Interacts (via GAE domain) with AFTPH/aftiphilin (By similarity). Interacts with TSG101 and UBC. Interacts with RNF11. Interacts (via VHS domain) with BACE1 (via DXXLL motif); the interaction highly increases when BACE1 is phosphorylated at 'Ser-498' (By similarity). Interacts with CNST (PubMed:19864490). Interacts with ADRA2B (By similarity). Interacts with ARL3; the interaction recruits, in collaboration with RABEP1, PKD1:PKD2 complex to trans-Golgi network and is required for ciliary targeting (PubMed:25405894). Q8R0H9; Q8CBC4-3: Cnst; NbExp=2; IntAct=EBI-2616212, EBI-2615407; Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Early endosome membrane ; Peripheral membrane protein The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (DXXLL motif). The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis. The unstructured hinge region contains clathrin-binding but no autoinhibitory (DXXLL) motifs. The GAE domain binds accessory proteins regulating GGAs function. Phosphorylated by CK2 and dephosphorylated by PP2A. Phosphorylation of GGA1 allows the internal DXXLL motif to bind the VHS domain and to inhibit the recognition of cargo signals. Ubiquitinated. Belongs to the GGA protein family. protein binding nucleoplasm endosome early endosome Golgi apparatus cytosol intracellular protein transport Golgi to plasma membrane transport protein localization endosome membrane protein transport membrane vesicle-mediated transport ADP-ribosylation factor binding early endosome membrane macromolecular complex protein localization to cell surface retrograde transport, endosome to Golgi Golgi to plasma membrane protein transport intracellular membrane-bounded organelle positive regulation of protein catabolic process protein heterodimerization activity toxin transport protein localization to ciliary membrane uc007wrn.1 uc007wrn.2 uc007wrn.3 
ENSMUST00000041588.13 Brat1 ENSMUST00000041588.13 BRCA1-associated ATM activator 1, transcript variant 2 (from RefSeq NM_181066.4) BRAT1_MOUSE Baat1 ENSMUST00000041588.1 ENSMUST00000041588.10 ENSMUST00000041588.11 ENSMUST00000041588.12 ENSMUST00000041588.2 ENSMUST00000041588.3 ENSMUST00000041588.4 ENSMUST00000041588.5 ENSMUST00000041588.6 ENSMUST00000041588.7 ENSMUST00000041588.8 ENSMUST00000041588.9 NM_181066 Q3TDC8 Q3U442 Q6NV65 Q8C3R1 Q8C3T3 Q9JKU7 uc009aic.1 uc009aic.2 uc009aic.3 uc009aic.4 A similar gene in human encodes a Breast Cancer 1 (BRCA1) interacting protein that is involved in cell cycle checkpoint signaling. The similar human protein is localized to DNA double strand breaks caused by ionizing radiation, and regulates cellular DNA damage response through interactions with Ataxia Telangiectasia Mutated (ATM) and DNA-dependent Protein Kinase. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation (By similarity). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). Interacts with BRCA1 and ATM. Interacts with MTOR, RPTOR, NDFIP1, SMC1A and PRKDC. Nucleus Cytoplasm Note=Present at double strand breaks (DSBs) following ionizing radiation treatment (By similarity). The ubiquitinated form localizes in the nucleus in a NDFIP1-dependent manner. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C3R1-1; Sequence=Displayed; Name=2; IsoId=Q8C3R1-2; Sequence=VSP_039548, VSP_039549; High levels detected in the cortex and much lower levels detected in the cerebellum, spinal cord and lung (at protein level). Ubiquitinated by NEDD4, NEDD4L and ITCH; mono- and polyubiquitinated forms are detected. Sequence=AAF43013.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE41674.1; Type=Frameshift; Evidence=; positive regulation of protein phosphorylation nucleus nucleoplasm cytoplasm glucose metabolic process apoptotic process cellular response to DNA damage stimulus cell proliferation response to ionizing radiation cell migration positive regulation of cell growth mitochondrion localization uc009aic.1 uc009aic.2 uc009aic.3 uc009aic.4 
ENSMUST00000041589.6 Tob1 ENSMUST00000041589.6 transducer of ErbB-2.1 (from RefSeq NM_009427.2) ENSMUST00000041589.1 ENSMUST00000041589.2 ENSMUST00000041589.3 ENSMUST00000041589.4 ENSMUST00000041589.5 NM_009427 Q61471 Q640M3 TOB1_MOUSE Tob Trob uc007kyf.1 uc007kyf.2 uc007kyf.3 Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay. Interacts with ERBB2. Interacts with CNOT7. Interacts with CPEB3 (via C-terminal RNA-binding region); recruits CNOT7 to CPEB3 to form a ternary complex required for mRNA deadenylation and decay. Interacts with CNOT8. Interacts with CPEB4. Q61471; P57737: CORO7; Xeno; NbExp=3; IntAct=EBI-8527498, EBI-6916167; Cytoplasm Nucleus Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. Ubiquitous. Phosphorylated on Ser and Thr residues. Belongs to the BTG family. transcription corepressor activity protein binding nucleus cytoplasm negative regulation of cell proliferation regulation of gene expression negative regulation of translation CCR4-NOT complex negative regulation of BMP signaling pathway receptor tyrosine kinase binding negative regulation of osteoblast differentiation SMAD binding negative regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of nuclear-transcribed mRNA poly(A) tail shortening regulation of SMAD protein import into nucleus positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of nucleic acid-templated transcription uc007kyf.1 uc007kyf.2 uc007kyf.3 
ENSMUST00000041591.16 Enpp2 ENSMUST00000041591.16 ectonucleotide pyrophosphatase/phosphodiesterase 2, transcript variant 2 (from RefSeq NM_015744.4) A8UH85 A8UH93 B2ZP54 ENPP2_MOUSE ENSMUST00000041591.1 ENSMUST00000041591.10 ENSMUST00000041591.11 ENSMUST00000041591.12 ENSMUST00000041591.13 ENSMUST00000041591.14 ENSMUST00000041591.15 ENSMUST00000041591.2 ENSMUST00000041591.3 ENSMUST00000041591.4 ENSMUST00000041591.5 ENSMUST00000041591.6 ENSMUST00000041591.7 ENSMUST00000041591.8 ENSMUST00000041591.9 NM_015744 Npps2 Pdnp2 Q6PDE0 Q99LG9 Q9R1E6 uc007vro.1 uc007vro.2 uc007vro.3 uc007vro.4 uc007vro.5 uc007vro.6 This gene encodes a member of the phosphodiesterase and nucleotide pyrophosphatase family of bifunctional enzymes that hydrolize phosphodiester bonds of various nucleotides. The encoded protein undergoes proteolytic processing to generate a mature protein with lysophospholipase D activity, catalyzing the cleavage of the choline group from lysophosphatidylcholine to produce lysophosphatidic acid. This gene is expressed in numerous tissues and participates in neural development, obesity, inflammation and oncogenesis. A complete lack of the encoded protein in mice results in aberrant vascular and neuronal development leading to embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]. Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:17208043, PubMed:28414242, PubMed:27780639). Major substrate is lysophosphatidylcholine (PubMed:17208043, PubMed:27780639). Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:18175805). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition (By similarity). Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor. Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn- 1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity). Reaction=1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-alkyl- sn-glycero-3-phosphate + ethanolamine + H(+); Xref=Rhea:RHEA:15965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57603, ChEBI:CHEBI:58014, ChEBI:CHEBI:76168; EC=3.1.4.39; Evidence= Reaction=1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O = 1-O- (9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:41684, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64396, ChEBI:CHEBI:78402; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41685; Evidence=; Reaction=a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn- glycerol 3-phosphate + choline + H(+); Xref=Rhea:RHEA:41712, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57875, ChEBI:CHEBI:64982; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41713; Evidence=; Reaction=a 2-acyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn- glycerol 3-phosphate + H(+) + L-serine; Xref=Rhea:RHEA:41716, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33384, ChEBI:CHEBI:64982, ChEBI:CHEBI:65214; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41717; Evidence=; Reaction=1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl- sn-glycerol 3-phosphate + choline + H(+); Xref=Rhea:RHEA:38991, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72682, ChEBI:CHEBI:74966; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38992; Evidence=; Reaction=H2O + sphing-4-enine-phosphocholine = choline + H(+) + sphing- 4-enine 1-phosphate; Xref=Rhea:RHEA:38919, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58906, ChEBI:CHEBI:60119; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38920; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z- octadecenoyl)-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:38915, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:74544; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38916; Evidence=; Reaction=1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1- tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+); Xref=Rhea:RHEA:38983, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64489, ChEBI:CHEBI:72683; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38984; Evidence=; Reaction=1-decanoyl-sn-glycero-3-phosphocholine + H2O = 1-decanoyl-sn- glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:41131, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:77724, ChEBI:CHEBI:77726; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41132; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:38975, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57518, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38976; Evidence=; Reaction=1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- octadecanoyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:38979, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73858, ChEBI:CHEBI:74565; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38980; Evidence=; Reaction=1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:41135, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28733, ChEBI:CHEBI:74547; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41136; Evidence=; Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:41139, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74344, ChEBI:CHEBI:74938; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41140; Evidence=; Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O- hexadecyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:41143, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64496, ChEBI:CHEBI:77580; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41144; Evidence=; Reaction=1-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn- glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:41400, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:78215, ChEBI:CHEBI:78223; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41401; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O = 1,2- dioctanoyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:41416, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:78228, ChEBI:CHEBI:78229; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41417; Evidence=; Reaction=1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2- didecanoyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:41412, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:78226, ChEBI:CHEBI:78227; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41413; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z- alkenyl)-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:41588, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:77283, ChEBI:CHEBI:77287; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41589; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+); Xref=Rhea:RHEA:38927, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57603, ChEBI:CHEBI:74544, ChEBI:CHEBI:74971; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38928; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 1- (9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine; Xref=Rhea:RHEA:38931, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33384, ChEBI:CHEBI:74544, ChEBI:CHEBI:74617; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38932; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Note=Binds 2 Zn(2+) ions per subunit. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= Note=Binds 1 Ca(2+) ion per subunit. Inhibited by EDTA and EGTA. Kinetic parameters: KM=12.9 mM for pNppp (isoform 1) ; KM=4.4 mM for pNppp (isoform 2) ; KM=11.8 mM for pNppp (isoform 3) ; Vmax=1.9 nmol/min/ug enzyme with pNppp as substrate (isoform 1) ; Vmax=0.35 nmol/min/ug enzyme with pNppp as substrate (isoform 2) ; Vmax=1.8 nmol/min/ug enzyme with pNppp as substrate (isoform 3) ; pH dependence: Optimum pH is 8.0 for isoforms 1, 2 and 3. ; Temperature dependence: Isoforms 1 and 3 have maximum activity from 45 to 55 degrees Celsius. ; Secreted Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Beta; IsoId=Q9R1E6-1; Sequence=Displayed; Name=2; Synonyms=Alpha; IsoId=Q9R1E6-2; Sequence=VSP_036396; Name=3; Synonyms=Gamma; IsoId=Q9R1E6-3; Sequence=VSP_036397; Expressed in brain and adipose tissue. Up-regulated in adipocytes of obese-diabetic db/db mice. N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity. Secretion requires simultaneous glycosylation on Asn-53 and Asn-410, while probable glycosylation of Asn-410 has a preferential role on lysoPLD activity. Not O- glycosylated. The interdomain disulfide bond between Cys-413 and Cys-805 is essential for catalytic activity. Note=May contribute to obesity (PubMed:15700135). Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. negative regulation of cell-matrix adhesion nucleic acid binding catalytic activity phosphodiesterase I activity nucleotide diphosphatase activity lysophospholipase activity scavenger receptor activity calcium ion binding extracellular region extracellular space cytoplasm Golgi apparatus integral component of plasma membrane lipid metabolic process phospholipid metabolic process endocytosis chemotaxis immune response zinc ion binding positive regulation of cell proliferation phospholipid catabolic process positive regulation of epithelial cell migration lipid catabolic process hydrolase activity polysaccharide binding regulation of cell migration phosphatidylcholine catabolic process estrous cycle regulation of angiogenesis metal ion binding alkylglycerophosphoethanolamine phosphodiesterase activity positive regulation of oligodendrocyte differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of focal adhesion assembly cell chemotaxis nucleic acid phosphodiester bond hydrolysis positive regulation of substrate adhesion-dependent cell spreading positive regulation of lamellipodium morphogenesis uc007vro.1 uc007vro.2 uc007vro.3 uc007vro.4 uc007vro.5 uc007vro.6 
ENSMUST00000041606.14 Necab1 ENSMUST00000041606.14 N-terminal EF-hand calcium binding protein 1 (from RefSeq NM_178617.4) ENSMUST00000041606.1 ENSMUST00000041606.10 ENSMUST00000041606.11 ENSMUST00000041606.12 ENSMUST00000041606.13 ENSMUST00000041606.2 ENSMUST00000041606.3 ENSMUST00000041606.4 ENSMUST00000041606.5 ENSMUST00000041606.6 ENSMUST00000041606.7 ENSMUST00000041606.8 ENSMUST00000041606.9 Efcbp1 NECA1_MOUSE NM_178617 Q80W91 Q8BG18 uc008sbi.1 uc008sbi.2 uc008sbi.3 Interacts with STX1. May interact with CPNE6. Cytoplasm Expressed in brain (at protein level). Expressed in the cerebral cortex only in layer 4, thalamic nuclei (the mediodorsal nucleus), hippocampus (a small band of pyramidal neurons at the boundary between CA1 and CA3), interneurons interspersed throughout the hippocampus proper, interneurons in the hilus, bodies of the neurons but also their dendritic projections (at protein level). blastocyst hatching calcium ion binding nucleus nucleoplasm cytoplasm cytosol regulation of amyloid precursor protein biosynthetic process metal ion binding uc008sbi.1 uc008sbi.2 uc008sbi.3 
ENSMUST00000041616.15 Pdxk ENSMUST00000041616.15 pyridoxal (pyridoxine, vitamin B6) kinase (from RefSeq NM_172134.2) ENSMUST00000041616.1 ENSMUST00000041616.10 ENSMUST00000041616.11 ENSMUST00000041616.12 ENSMUST00000041616.13 ENSMUST00000041616.14 ENSMUST00000041616.2 ENSMUST00000041616.3 ENSMUST00000041616.4 ENSMUST00000041616.5 ENSMUST00000041616.6 ENSMUST00000041616.7 ENSMUST00000041616.8 ENSMUST00000041616.9 NM_172134 PDXK_MOUSE Pdxk Pkh Q3TM83 Q8BJQ5 Q8K183 uc007fxu.1 uc007fxu.2 uc007fxu.3 uc007fxu.4 Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (By similarity). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity). Reaction=ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate; Xref=Rhea:RHEA:10224, ChEBI:CHEBI:15378, ChEBI:CHEBI:17310, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216, ChEBI:CHEBI:597326; EC=2.7.1.35; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10225; Evidence=; Reaction=ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate; Xref=Rhea:RHEA:25104, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57761, ChEBI:CHEBI:58451, ChEBI:CHEBI:456216; EC=2.7.1.35; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25105; Evidence=; Reaction=ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate; Xref=Rhea:RHEA:25108, ChEBI:CHEBI:15378, ChEBI:CHEBI:16709, ChEBI:CHEBI:30616, ChEBI:CHEBI:58589, ChEBI:CHEBI:456216; EC=2.7.1.35; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25109; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activity is increased in the presence of K(+)or Na(+). Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1. Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1. Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1. Homodimer. Cytoplasm, cytosol Belongs to the pyridoxine kinase family. nucleotide binding magnesium ion binding ATP binding nucleoplasm cytoplasm cytosol drug binding zinc ion binding cell proliferation pyridoxal kinase activity pyridoxal 5'-phosphate salvage kinase activity phosphorylation transferase activity pyridoxal phosphate binding potassium ion binding sodium ion binding lithium ion binding protein homodimerization activity pyridoxal phosphate biosynthetic process negative regulation of apoptotic process metal ion binding pyridoxal binding uc007fxu.1 uc007fxu.2 uc007fxu.3 uc007fxu.4 
ENSMUST00000041618.13 Taf4 ENSMUST00000041618.13 TATA-box binding protein associated factor 4 (from RefSeq NM_001081092.2) E9QAP7 E9QAP7_MOUSE ENSMUST00000041618.1 ENSMUST00000041618.10 ENSMUST00000041618.11 ENSMUST00000041618.12 ENSMUST00000041618.2 ENSMUST00000041618.3 ENSMUST00000041618.4 ENSMUST00000041618.5 ENSMUST00000041618.6 ENSMUST00000041618.7 ENSMUST00000041618.8 ENSMUST00000041618.9 NM_001081092 Taf4 Taf4a uc008ohw.1 uc008ohw.2 uc008ohw.3 Nucleus Belongs to the TAF4 family. nuclear chromatin ovarian follicle development DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor TFIID complex cytosol DNA-templated transcription, initiation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter transcription factor binding aryl hydrocarbon receptor binding macromolecular complex transcription factor TFTC complex positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity MLL1 complex uc008ohw.1 uc008ohw.2 uc008ohw.3 
ENSMUST00000041621.5 Lipt1 ENSMUST00000041621.5 lipoyltransferase 1, transcript variant 7 (from RefSeq NM_001377034.1) ENSMUST00000041621.1 ENSMUST00000041621.2 ENSMUST00000041621.3 ENSMUST00000041621.4 LIPT_MOUSE Lipt1 NM_001377034 Q8VCM4 uc007ash.1 uc007ash.2 uc007ash.3 uc007ash.4 Lipoyl amidotransferase that catalyzes the transfer of lipoyl moieties from lipoyl-protein H of the glycine cleavage system (lipoyl- GCSH) to E2 subunits of the pyruvate dehydrogenase complex (PDCE2). Unable to catalyze the transfer of octanoyl from octanoyl-GCSH to PDCE2 (By similarity). In vitro, it is also able to catalyze the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes but this reaction may not be physiologically relevant (By similarity). Reaction=(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = AMP + 2 H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]; Xref=Rhea:RHEA:20473, Rhea:RHEA-COMP:10500, Rhea:RHEA-COMP:10502, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:83091, ChEBI:CHEBI:83099, ChEBI:CHEBI:456215; Evidence=; Reaction=L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-lipoyl]-L-lysyl- [glycine-cleavage complex H protein] = L-lysyl-[glycine-cleavage complex H protein] + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]; Xref=Rhea:RHEA:16413, Rhea:RHEA-COMP:10494, Rhea:RHEA- COMP:10500, Rhea:RHEA-COMP:10501, Rhea:RHEA-COMP:10502, ChEBI:CHEBI:29969, ChEBI:CHEBI:83099; EC=2.3.1.200; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16414; Evidence=; Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2. Mitochondrion Belongs to the LplA family. mitochondrion cellular protein modification process protein lipoylation transferase activity transferase activity, transferring acyl groups uc007ash.1 uc007ash.2 uc007ash.3 uc007ash.4 
ENSMUST00000041623.9 Enc1 ENSMUST00000041623.9 ectodermal-neural cortex 1 (from RefSeq NM_007930.4) ENC1_MOUSE ENSMUST00000041623.1 ENSMUST00000041623.2 ENSMUST00000041623.3 ENSMUST00000041623.4 ENSMUST00000041623.5 ENSMUST00000041623.6 ENSMUST00000041623.7 ENSMUST00000041623.8 Enc-1 NM_007930 O35709 Q8C7V2 uc007rod.1 uc007rod.2 uc007rod.3 uc007rod.4 Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down- regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism (By similarity). Binds to RB1. Hypophosphorylated RB1 associates with ENC1 during neuronal differentiation, while hyperphosphorylated RB1 associates with ENC1 in undifferentiating cells. Part of a complex that contains CUL3, RBX1 and ENC1 (By similarity). Interacts indirectly with KEAP1 (By similarity). Nucleus matrix Cytoplasm. Cytoplasm, cytoskeleton. Note=Interacts with the actin cytoskeleton. Primarily expressed in the nervous system. Expression is highly dynamic but mostly restricted to the nervous system. Outside the nervous system, expression is detected in the rostral-most somitomere of the presomitic mesoderm, at the times corresponding to the epithelialization that precedes somite formation. First detected in the brain and spinal cord of 12 PC embryos. Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination (By similarity). nuclear chromatin actin binding nucleus nucleoplasm nucleolus cytoplasm cytoskeleton multicellular organism development nervous system development proteasomal ubiquitin-independent protein catabolic process positive regulation of neuron projection development nuclear matrix protein ubiquitination negative regulation of translation Cul3-RING ubiquitin ligase complex neuronal cell body uc007rod.1 uc007rod.2 uc007rod.3 uc007rod.4 
ENSMUST00000041627.14 Sdk2 ENSMUST00000041627.14 sidekick cell adhesion molecule 2 (from RefSeq NM_172800.3) ENSMUST00000041627.1 ENSMUST00000041627.10 ENSMUST00000041627.11 ENSMUST00000041627.12 ENSMUST00000041627.13 ENSMUST00000041627.2 ENSMUST00000041627.3 ENSMUST00000041627.4 ENSMUST00000041627.5 ENSMUST00000041627.6 ENSMUST00000041627.7 ENSMUST00000041627.8 ENSMUST00000041627.9 Kiaa1514 NM_172800 Q3TTK1 Q5U5W7 Q6V4S5 Q6ZPP2 SDK2_MOUSE Sdk2 uc007mfe.1 uc007mfe.2 uc007mfe.3 Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion (PubMed:26287463). Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion (PubMed:26287463). Promotes synaptic connectivity via homophilic interactions (PubMed:26287463). Homodimer; mediates homophilic interactions to promote cell adhesion (PubMed:15703275, PubMed:26287463). Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4 (PubMed:20219992). Cell membrane ; Single-pass type I membrane protein Synapse Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6V4S5-1; Sequence=Displayed; Name=2; IsoId=Q6V4S5-2; Sequence=VSP_017526; Name=3; IsoId=Q6V4S5-3; Sequence=VSP_017527, VSP_017528; Expressed in retinal ganglion cells (RGCs) that form synapses in distinct inner plexiform layer (IPL) sublaminae. Specifically expressed in specific subsets of retinal ganglion cells (RGCs), named W3B-RGCs, that specifically respond when the timing of the movement of a small object differs from that of the background, but not when they coincide (at protein level). Also present in excitatory amacrine cell type called VG3-ACs, that provide strong and selective input W3B-RGCs (at protein level) (PubMed:26287463). Expressed at low levels in the glomeruli (PubMed:15213259). Highly expressed in many fetal tissues, inlcuding kidney but shows markedly lower expression in adult organs. Expression in kidney is high throughout development with maximal expression occurring near birth. the PDZ-binding motif mediates interaction with PDZ domain- containing proteins MAGI1, MAGI2, DLG2, DLG3 and DLG4 and is required for is required for synaptic localization in photoreceptors. Mice are viable and fertile but show decreased synaptic connectivity between the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. [Isoform 3]: Due to intron retention. Belongs to the sidekick family. Name=Protein Spotlight; Note=Discerning change - Issue 176 of February 2016; URL="https://web.expasy.org/spotlight/back_issues/176/"; molecular_function plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly retina layer formation membrane integral component of membrane cell junction synapse camera-type eye photoreceptor cell differentiation uc007mfe.1 uc007mfe.2 uc007mfe.3 
ENSMUST00000041638.8 Gtf3c3 ENSMUST00000041638.8 general transcription factor IIIC, polypeptide 3 (from RefSeq NM_001033194.3) AL022818 ENSMUST00000041638.1 ENSMUST00000041638.2 ENSMUST00000041638.3 ENSMUST00000041638.4 ENSMUST00000041638.5 ENSMUST00000041638.6 ENSMUST00000041638.7 Gtf3c3 NM_001033194 Q3TMP1 Q3TMP1_MOUSE uc007azp.1 uc007azp.2 uc007azp.3 uc007azp.4 transcription factor TFIIIC complex transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting nucleus nucleolus transcription from RNA polymerase III promoter nuclear membrane RNA polymerase III transcriptional preinitiation complex assembly transcription factor activity, core RNA polymerase III binding uc007azp.1 uc007azp.2 uc007azp.3 uc007azp.4 
ENSMUST00000041640.5 Ankmy2 ENSMUST00000041640.5 ankyrin repeat and MYND domain containing 2 (from RefSeq NM_146033.3) ANKY2_MOUSE ENSMUST00000041640.1 ENSMUST00000041640.2 ENSMUST00000041640.3 ENSMUST00000041640.4 NM_146033 Q3TPE9 Q8BK14 Q8BYW5 Q8R3N4 Q921J1 uc007njt.1 uc007njt.2 uc007njt.3 uc007njt.4 May be involved in the trafficking of signaling proteins to the cilia. Interacts with the retinal-specific guanylyl cyclase GC1. Cell projection, cilium Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TPE9-1; Sequence=Displayed; Name=2; IsoId=Q3TPE9-2; Sequence=VSP_019937, VSP_019938; Sequence=BAC29839.1; Type=Frameshift; Evidence=; cellular_component cilium enzyme binding cell projection metal ion binding uc007njt.1 uc007njt.2 uc007njt.3 uc007njt.4 
ENSMUST00000041643.5 Pcif1 ENSMUST00000041643.5 phosphorylated CTD interacting factor 1, transcript variant 4 (from RefSeq NM_146129.3) ENSMUST00000041643.1 ENSMUST00000041643.2 ENSMUST00000041643.3 ENSMUST00000041643.4 NM_146129 Pcif1 Q542C3 Q542C3_MOUSE uc008nwp.1 uc008nwp.2 uc008nwp.3 uc008nwp.4 nucleus nucleoplasm negative regulation of phosphatase activity microtubule cytoskeleton mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity intercellular bridge positive regulation of translation mRNA methylation RNA polymerase II C-terminal domain binding S-adenosyl-L-methionine binding uc008nwp.1 uc008nwp.2 uc008nwp.3 uc008nwp.4 
ENSMUST00000041646.4 Drd5 ENSMUST00000041646.4 dopamine receptor D5 (from RefSeq NM_013503.4) DRD5_MOUSE ENSMUST00000041646.1 ENSMUST00000041646.2 ENSMUST00000041646.3 NM_013503 Q61439 Q80UB7 Q8BLD9 uc008xgn.1 uc008xgn.2 uc008xgn.3 uc008xgn.4 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. dopamine neurotransmitter receptor activity, coupled via Gs synaptic transmission, dopaminergic G-protein alpha-subunit binding response to amphetamine regulation of systemic arterial blood pressure by vasopressin norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure G-protein coupled receptor activity adrenergic receptor activity dopamine neurotransmitter receptor activity plasma membrane integral component of plasma membrane cilium negative regulation of protein kinase activity signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway dopamine receptor signaling pathway mating behavior drug binding associative learning visual learning membrane integral component of membrane transmission of nerve impulse negative regulation of cell migration axon dendrite brush border membrane negative regulation of NAD(P)H oxidase activity dopamine binding wound healing response to cocaine neuronal cell body dendritic spine negative regulation of blood pressure regulation of female receptivity sensitization regulation of long-term neuronal synaptic plasticity ciliary membrane long term synaptic depression cellular response to catecholamine stimulus adenylate cyclase-activating adrenergic receptor signaling pathway reactive oxygen species metabolic process non-motile cilium glutamatergic synapse integral component of postsynaptic density membrane regulation of postsynaptic specialization membrane neurotransmitter receptor levels uc008xgn.1 uc008xgn.2 uc008xgn.3 uc008xgn.4 
ENSMUST00000041649.8 Prss22 ENSMUST00000041649.8 serine protease 22 (from RefSeq NM_133731.2) BSSP4_MOUSE Bssp4 ENSMUST00000041649.1 ENSMUST00000041649.2 ENSMUST00000041649.3 ENSMUST00000041649.4 ENSMUST00000041649.5 ENSMUST00000041649.6 ENSMUST00000041649.7 NM_133731 Prss26 Q7TML0 Q9ER10 uc012amb.1 uc012amb.2 Belongs to the peptidase S1 family. serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc012amb.1 uc012amb.2 
ENSMUST00000041659.7 Prrx2 ENSMUST00000041659.7 paired related homeobox 2 (from RefSeq NM_009116.3) A2APZ7 A2APZ7_MOUSE ENSMUST00000041659.1 ENSMUST00000041659.2 ENSMUST00000041659.3 ENSMUST00000041659.4 ENSMUST00000041659.5 ENSMUST00000041659.6 NM_009116 Prrx2 uc008jcy.1 uc008jcy.2 uc008jcy.3 uc008jcy.4 Nucleus Belongs to the paired homeobox family. DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development sequence-specific DNA binding uc008jcy.1 uc008jcy.2 uc008jcy.3 uc008jcy.4 
ENSMUST00000041662.3 H2-M1 ENSMUST00000041662.3 histocompatibility 2, M region locus 1 (from RefSeq NM_177636.2) ENSMUST00000041662.1 ENSMUST00000041662.2 H2-M1 NM_177636 Q31200 Q31200_MOUSE uc008cld.1 uc008cld.2 uc008cld.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc008cld.1 uc008cld.2 uc008cld.3 
ENSMUST00000041674.14 Btn1a1 ENSMUST00000041674.14 butyrophilin, subfamily 1, member A1 (from RefSeq NM_013483.3) BT1A1_MOUSE Btn ENSMUST00000041674.1 ENSMUST00000041674.10 ENSMUST00000041674.11 ENSMUST00000041674.12 ENSMUST00000041674.13 ENSMUST00000041674.2 ENSMUST00000041674.3 ENSMUST00000041674.4 ENSMUST00000041674.5 ENSMUST00000041674.6 ENSMUST00000041674.7 ENSMUST00000041674.8 ENSMUST00000041674.9 NM_013483 P97392 Q62556 Q8K2H7 Q921K7 uc007ptr.1 uc007ptr.2 uc007ptr.3 uc007ptr.4 uc007ptr.5 May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Seems to associate with xanthine dehydrogenase/oxidase. Membrane; Single-pass type I membrane protein. Note=Secreted in association with the milk-fat-globule membrane during lactation. Strongly expressed in lactating mammary tissue (at protein level). About 100-fold lower levels in virgin mammary tissue. Also detected in spleen and thymus at 10-20 times lower levels compared to those detected in virgin mammary gland. Very low levels in several other tissues, including brain, heart, kidney, lymph node, lung and small intestine. In the thymus, detected in the stroma, in epithelial cells (at protein level). Most prominent in medullary areas of the thymus and at the corticomedullary junction (at protein level). Expression increases during the last half of pregnancy and is maximal during lactation. N-glycosylated. Belongs to the immunoglobulin superfamily. BTN/MOG family. Sequence=AAB35893.1; Type=Frameshift; Evidence=; receptor binding protein binding external side of plasma membrane membrane integral component of membrane regulation of immune response T cell receptor signaling pathway uc007ptr.1 uc007ptr.2 uc007ptr.3 uc007ptr.4 uc007ptr.5 
ENSMUST00000041676.3 Hrh4 ENSMUST00000041676.3 histamine receptor H4 (from RefSeq NM_153087.2) ENSMUST00000041676.1 ENSMUST00000041676.2 HRH4_MOUSE NM_153087 Q91ZY2 uc008edb.1 uc008edb.2 The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist) (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity histamine receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway positive regulation of cytosolic calcium ion concentration chemical synaptic transmission membrane integral component of membrane G-protein coupled acetylcholine receptor activity dendrite neurotransmitter receptor activity regulation of MAPK cascade uc008edb.1 uc008edb.2 
ENSMUST00000041683.9 Usp22 ENSMUST00000041683.9 ubiquitin specific peptidase 22 (from RefSeq NM_001004143.4) ENSMUST00000041683.1 ENSMUST00000041683.2 ENSMUST00000041683.3 ENSMUST00000041683.4 ENSMUST00000041683.5 ENSMUST00000041683.6 ENSMUST00000041683.7 ENSMUST00000041683.8 Kiaa1063 NM_001004143 Q3TU34 Q3U2W4 Q5DU02 Q5SU81 Q66JV8 Q6PDX3 Q8BJG3 UBP22_MOUSE uc007jhc.1 uc007jhc.2 uc007jhc.3 uc007jhc.4 Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recruitment to the SAGA complex. Interacts with ATXN7L3 and weakly with ATXN7L3B. Nucleus Highly expressed in brain and weakly in other organs. Highly expressed between 10.5 dpc and 12.5 dpc. Expressed in the midbrain, forebrain, hindbrain and dorsal root ganglia of embryos at 12.5 dpc. Belongs to the peptidase C19 family. UBP8 subfamily. Sequence=BAD90248.1; Type=Erroneous initiation; Evidence=; SAGA complex transcription coactivator activity thiol-dependent ubiquitin-specific protease activity nucleus chromatin organization proteolysis ubiquitin-dependent protein catabolic process cell cycle peptidase activity cysteine-type peptidase activity zinc ion binding H4 histone acetyltransferase activity histone ubiquitination histone deubiquitination protein deubiquitination nuclear speck hydrolase activity enzyme binding ligand-dependent nuclear receptor transcription coactivator activity thiol-dependent ubiquitinyl hydrolase activity histone H4 acetylation positive regulation of transcription, DNA-templated positive regulation of mitotic cell cycle metal ion binding SAGA-type complex uc007jhc.1 uc007jhc.2 uc007jhc.3 uc007jhc.4 
ENSMUST00000041684.11 Caskin2 ENSMUST00000041684.11 CASK-interacting protein 2 (from RefSeq NM_080643.2) B1ATA2 CSKI2_MOUSE ENSMUST00000041684.1 ENSMUST00000041684.10 ENSMUST00000041684.2 ENSMUST00000041684.3 ENSMUST00000041684.4 ENSMUST00000041684.5 ENSMUST00000041684.6 ENSMUST00000041684.7 ENSMUST00000041684.8 ENSMUST00000041684.9 Kiaa1139 NM_080643 Q6ZPX1 Q7TS77 Q8VHK1 uc007mip.1 uc007mip.2 uc007mip.3 May not bind CASK. Cytoplasm Sequence=BAC98107.1; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm membrane uc007mip.1 uc007mip.2 uc007mip.3 
ENSMUST00000041685.7 Neurod2 ENSMUST00000041685.7 neurogenic differentiation 2 (from RefSeq NM_010895.3) ENSMUST00000041685.1 ENSMUST00000041685.2 ENSMUST00000041685.3 ENSMUST00000041685.4 ENSMUST00000041685.5 ENSMUST00000041685.6 NDF2_MOUSE NM_010895 Ndrf Q61952 Q62414 Q925V5 uc009vai.1 uc009vai.2 uc009vai.3 Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down- regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter. Interacts with TCF3, TCF4 and TCF12. Interacts with CDC20. Efficient DNA-binding and transcription activation require dimerization with another bHLH protein. Nucleus Expressed in the external germinal layer (EGL) and internal granular layer (IGL) of the cerebellum (at protein level). Expressed in layers V and VI of the neocortex at postnatal day 1. Expressed in all layers of the neocortex at postnatal day 4. Strongly expressed in layer IV of the neocortex, particularly in the barrel cortex at postnatal day 7. Expressed in the CA1, CA2 and CA3 and dentate gyrus of the hippocampus and many nuclei such as the habenular thalamic nuclei, paraventricular hypothalamic nuclei, amygdala nuclei, and pyramidal nucleus. Expressed in granule cells, molecular layer neurons, and deep cerebella nuclei of the cerebellum. Expressed in brainstem neurons in the external cuneate nucleus and central gray. Expressed in dorsal and ventral parts of the lateral, basolateral and basomedial amygdala at 17 and 18 dpc (at protein level). Initially expressed in embryo at 11 dpc, with persistent expression in the nervous system until birth. The C-terminal region is necessary for depolarization-induced and calcium-dependent transcription activation. Ubiquitinated by the APC/C complex; leading to its degradation in neurons. The CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. Mice exhibit small brains, ataxia, reduced seizure threshold, growth failure, and postnatal premature death. Show excessive apoptosis in central nervous system. Lacks nuclei of the lateral and basolateral amygdala. Organization of cortical neurons into barrel structures is disrupted; thalamocortical axon terminals fail to segregate in the somatosensory cortex. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding behavioral fear response DNA binding transcription corepressor activity protein binding nucleus regulation of transcription, DNA-templated multicellular organism development nervous system development associative learning protein ubiquitination cerebellar cortex development cell differentiation positive regulation of synaptic plasticity regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity neuron development positive regulation of calcium-mediated signaling positive regulation of sequence-specific DNA binding transcription factor activity E-box binding cellular response to electrical stimulus cellular response to calcium ion regulation of synapse maturation positive regulation of synapse maturation negative regulation of nucleic acid-templated transcription negative regulation of synapse maturation uc009vai.1 uc009vai.2 uc009vai.3 
ENSMUST00000041705.8 Spata20 ENSMUST00000041705.8 spermatogenesis associated 20 (from RefSeq NM_144827.4) ENSMUST00000041705.1 ENSMUST00000041705.2 ENSMUST00000041705.3 ENSMUST00000041705.4 ENSMUST00000041705.5 ENSMUST00000041705.6 ENSMUST00000041705.7 NM_144827 Q80YT5 SPT20_MOUSE Tisp78 uc007kyt.1 uc007kyt.2 uc007kyt.3 May play a role in fertility regulation. Secreted Detected in 28- and 75-day-old mouse testes. No expression detected at 21 days. catalytic activity protein binding extracellular region multicellular organism development spermatogenesis cell differentiation uc007kyt.1 uc007kyt.2 uc007kyt.3 
ENSMUST00000041708.10 Gpr34 ENSMUST00000041708.10 G protein-coupled receptor 34 (from RefSeq NM_011823.5) ENSMUST00000041708.1 ENSMUST00000041708.2 ENSMUST00000041708.3 ENSMUST00000041708.4 ENSMUST00000041708.5 ENSMUST00000041708.6 ENSMUST00000041708.7 ENSMUST00000041708.8 ENSMUST00000041708.9 GPR34_MOUSE NM_011823 Q9R1K6 uc009srt.1 uc009srt.2 uc009srt.3 G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:21097509, PubMed:26851221, PubMed:34107271). Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils. Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production (PubMed:34107271). Plays an important role in microglial function, controlling morphology and phagocytosis (PubMed:25142016). Cell membrane ; Multi-pass membrane protein Highly expressed in glial cells such as astrocytes and microglia. MAPKs and NF-kappa-B reduce GPR34 mRNA expression independent of TLRs and TLR stimulation also reduced GPR34 mRNA levels. GPR34-deficiency mice show no difference in microglial motility but display a significantly reduced phagocytosis activity (PubMed:25142016). In addition, they are more susceptible towards disseminating Cryptococcus neoformans infection with higher pathogen burden in extrapulmonary tissues after pulmonary infection (PubMed:21097509). GPR34-deficient dendritic cells show a commitment to apoptosis, which could result in an altered immune response (PubMed:26851221). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane G-protein coupled purinergic nucleotide receptor signaling pathway G-protein coupled purinergic nucleotide receptor activity uc009srt.1 uc009srt.2 uc009srt.3 
ENSMUST00000041723.15 Zdhhc17 ENSMUST00000041723.15 zinc finger, DHHC domain containing 17, transcript variant 1 (from RefSeq NM_172554.2) ENSMUST00000041723.1 ENSMUST00000041723.10 ENSMUST00000041723.11 ENSMUST00000041723.12 ENSMUST00000041723.13 ENSMUST00000041723.14 ENSMUST00000041723.2 ENSMUST00000041723.3 ENSMUST00000041723.4 ENSMUST00000041723.5 ENSMUST00000041723.6 ENSMUST00000041723.7 ENSMUST00000041723.8 ENSMUST00000041723.9 Hip14 Kiaa0946 NM_172554 Q80TN5 Q8BJ08 Q8BYQ2 Q8BYQ6 ZDH17_MOUSE Zdhhc17 uc033fsq.1 uc033fsq.2 uc033fsq.3 uc033fsq.4 Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:15489887, PubMed:15603741, PubMed:25253725, PubMed:27911442). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (PubMed:28167757). Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15489887, PubMed:15603741, PubMed:25253725). Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (By similarity). Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (PubMed:26232532). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (By similarity). May play a role in Mg(2+) transport (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (PubMed:18596047). Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation (PubMed:27911442). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence= Reaction=L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S- tetradecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59736, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:15433, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:143199; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59737; Evidence=; Reaction=L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S- octadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59740, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:15434, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:143200; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59741; Evidence=; Interacts (via ANK repeats) with numerous proteins (via the consensus sequence motif [VIAP]-[VIT]-x-x-Q-P) (By similarity). Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with HTT (PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (PubMed:26198635). Interacts (via ANK repeats) with SNAP25 (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with EVL (By similarity). Interacts with SPRED1 and SPRED3 (PubMed:24705354). Interacts with GPM6A and OPTN (By similarity). May interact (via ANK repeats) with SPRED2 (PubMed:28882895). May interact with NTRK1; may regulate its localization and function (PubMed:26232532). Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Presynaptic cell membrane ; Multi-pass membrane protein Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80TN5-1; Sequence=Displayed; Name=2; IsoId=Q80TN5-2; Sequence=VSP_010026, VSP_010027; Expressed in liver, testis, kidney, heart, pancreas and brain. Highest expression was seen in the brain. Localized predominantly in the perinuclear regions of neurons from the cortex, striatum and hippocampus. Colocalized with HTT in the medium spiny neurons of the striatum and the spiny neurons that project into the globus pallidus. Highly expressed in neurons during their differentiation. Up-regulated by low extracellular Mg(2+). The DHHC domain is required for palmitoyltransferase activity. Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. Sequence=AAH58772.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC30090.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC30097.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC32912.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC65688.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi membrane protein binding Golgi apparatus plasma membrane magnesium ion transmembrane transporter activity membrane integral component of membrane aggresome palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups protein palmitoylation protein-cysteine S-palmitoyltransferase activity cell junction cytoplasmic vesicle membrane Golgi-associated vesicle membrane cytoplasmic vesicle presynaptic membrane identical protein binding lipoprotein transport intracellular membrane-bounded organelle synapse magnesium ion transmembrane transport uc033fsq.1 uc033fsq.2 uc033fsq.3 uc033fsq.4 
ENSMUST00000041725.14 Mgat4b ENSMUST00000041725.14 mannoside acetylglucosaminyltransferase 4, isoenzyme B (from RefSeq NM_145926.3) ENSMUST00000041725.1 ENSMUST00000041725.10 ENSMUST00000041725.11 ENSMUST00000041725.12 ENSMUST00000041725.13 ENSMUST00000041725.2 ENSMUST00000041725.3 ENSMUST00000041725.4 ENSMUST00000041725.5 ENSMUST00000041725.6 ENSMUST00000041725.7 ENSMUST00000041725.8 ENSMUST00000041725.9 MGT4B_MOUSE Mgat4b NM_145926 Q3U2D9 Q812F8 Q812F9 Q8R0L4 uc007iry.1 uc007iry.2 uc007iry.3 Glycosyltransferase that catalyzes the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains. Prefers complex-type N-glycans over hybrid-types. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N- glycan biosynthesis. Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc- (1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D- glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc- (1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]- beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl- [protein] + UDP; Xref=Rhea:RHEA:16057, Rhea:RHEA-COMP:13526, Rhea:RHEA-COMP:14374, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:60651, ChEBI:CHEBI:139507; EC=2.4.1.145; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16058; Evidence=; Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- (1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L- asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)- [alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D- GlcNAc}-L-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:69615, Rhea:RHEA-COMP:14369, Rhea:RHEA-COMP:17732, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:60615, ChEBI:CHEBI:187873; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69616; Evidence=; Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc- (1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N- acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta- D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D- GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc- (1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:69619, Rhea:RHEA-COMP:17733, Rhea:RHEA-COMP:17734, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:187874, ChEBI:CHEBI:187875; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69620; Evidence=; Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc- (1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- [alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N- acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta- D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D- Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc- (1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:69623, Rhea:RHEA-COMP:13532, Rhea:RHEA-COMP:18198, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:137207, ChEBI:CHEBI:187877; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69624; Evidence=; Reaction=N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man- (1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N- acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D- GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D- GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc- (1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:69627, Rhea:RHEA-COMP:17737, Rhea:RHEA-COMP:17738, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:187878, ChEBI:CHEBI:187879; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69628; Evidence=; Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- (1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N- acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta- D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man- (1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc}-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:69631, Rhea:RHEA-COMP:17739, Rhea:RHEA-COMP:17740, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:187880, ChEBI:CHEBI:187881; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69632; Evidence=; Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man- (1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)- [beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D- GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:69635, Rhea:RHEA-COMP:17741, Rhea:RHEA-COMP:17742, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:187882, ChEBI:CHEBI:187883; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69636; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Protein modification; protein glycosylation. Interacts with SLC35A3. Golgi apparatus membrane ; Single-pass type II membrane protein Note=A processed soluble form also exists. N-glycosylated. Belongs to the glycosyltransferase 54 family. Sequence=AAH26638.1; Type=Erroneous initiation; Evidence=; Sequence=AAH31613.1; Type=Erroneous initiation; Evidence=; Golgi membrane endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus Golgi stack protein glycosylation protein N-linked glycosylation acetylglucosaminyltransferase activity alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups metal ion binding uc007iry.1 uc007iry.2 uc007iry.3 
ENSMUST00000041726.4 Asb6 ENSMUST00000041726.4 ankyrin repeat and SOCS box-containing 6 (from RefSeq NM_133346.2) ASB6_MOUSE ENSMUST00000041726.1 ENSMUST00000041726.2 ENSMUST00000041726.3 NM_133346 Q8VEC6 Q91ZU1 uc008jcx.1 uc008jcx.2 uc008jcx.3 uc008jcx.4 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Binds APS. Identified in a complex with ELOB and ELOC. Interacts with CUL5 and RNF7 (By similarity). Cytoplasm Detected in adipocytes. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Belongs to the ankyrin SOCS box (ASB) family. molecular_function cellular_component cytoplasm biological_process protein ubiquitination intracellular signal transduction uc008jcx.1 uc008jcx.2 uc008jcx.3 uc008jcx.4 
ENSMUST00000041730.12 Lmx1b ENSMUST00000041730.12 LIM homeobox transcription factor 1 beta (from RefSeq NM_010725.3) A0A0R4J0I7 A0A0R4J0I7_MOUSE ENSMUST00000041730.1 ENSMUST00000041730.10 ENSMUST00000041730.11 ENSMUST00000041730.2 ENSMUST00000041730.3 ENSMUST00000041730.4 ENSMUST00000041730.5 ENSMUST00000041730.6 ENSMUST00000041730.7 ENSMUST00000041730.8 ENSMUST00000041730.9 Lmx1b NM_010725 uc008jhy.1 uc008jhy.2 uc008jhy.3 uc008jhy.4 Nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc008jhy.1 uc008jhy.2 uc008jhy.3 uc008jhy.4 
ENSMUST00000041732.9 Kirrel1 ENSMUST00000041732.9 Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:11416156). Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. (from UniProt Q80W68) BC023765 ENSMUST00000041732.1 ENSMUST00000041732.2 ENSMUST00000041732.3 ENSMUST00000041732.4 ENSMUST00000041732.5 ENSMUST00000041732.6 ENSMUST00000041732.7 ENSMUST00000041732.8 KIRR1_MOUSE Kirrel Neph1 Q80W68 Q8CIJ4 Q8CJ59 Q923L4 uc008prx.1 uc008prx.2 uc008prx.3 uc008prx.4 Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:11416156). Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C- terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL1 glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylated with GRB2 (By similarity). Cell membrane ; Single-pass type I membrane protein Note=Predominantly located at podocyte slit diaphragm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80W68-1; Sequence=Displayed; Name=2; IsoId=Q80W68-2; Sequence=VSP_011736, VSP_011737; Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. Phosphorylation probably regulates the interaction with NPHS2. Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding (By similarity). N-glycosylated. Knockout of this gene results in perinatal lethality accompanied by proteinuria, and effacement of glomerular podocytes. Belongs to the immunoglobulin superfamily. Sequence=AAK00528.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAK00528.1; Type=Frameshift; Evidence=; negative regulation of protein phosphorylation protein binding plasma membrane cell-cell junction excretion membrane integral component of membrane myosin binding positive regulation of actin filament polymerization cell projection membrane dendritic shaft membrane raft perinuclear region of cytoplasm cell-cell adhesion uc008prx.1 uc008prx.2 uc008prx.3 uc008prx.4 
ENSMUST00000041733.9 Taf2 ENSMUST00000041733.9 TATA-box binding protein associated factor 2 (from RefSeq NM_001081288.1) B9EJX5 B9EJX5_MOUSE ENSMUST00000041733.1 ENSMUST00000041733.2 ENSMUST00000041733.3 ENSMUST00000041733.4 ENSMUST00000041733.5 ENSMUST00000041733.6 ENSMUST00000041733.7 ENSMUST00000041733.8 NM_001081288 Taf2 uc007vrt.1 uc007vrt.2 uc007vrt.3 Nucleus Belongs to the TAF2 family. G2/M transition of mitotic cell cycle TFIID-class transcription factor binding transcription factor TFIID complex transcription initiation from RNA polymerase II promoter response to organic cyclic compound transcription factor TFTC complex transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter uc007vrt.1 uc007vrt.2 uc007vrt.3 
ENSMUST00000041736.11 Hdac11 ENSMUST00000041736.11 histone deacetylase 11 (from RefSeq NM_144919.2) ENSMUST00000041736.1 ENSMUST00000041736.10 ENSMUST00000041736.2 ENSMUST00000041736.3 ENSMUST00000041736.4 ENSMUST00000041736.5 ENSMUST00000041736.6 ENSMUST00000041736.7 ENSMUST00000041736.8 ENSMUST00000041736.9 HDA11_MOUSE NM_144919 Q91WA3 uc009cxv.1 uc009cxv.2 uc009cxv.3 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA- COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; Interacts with HDAC6. Nucleus Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor. Belongs to the histone deacetylase family. histone deacetylase complex histone deacetylase activity protein binding nucleus cytoplasm plasma membrane chromatin organization transcription factor binding oligodendrocyte development histone deacetylation hydrolase activity NAD-dependent histone deacetylase activity (H3-K14 specific) histone H3 deacetylation uc009cxv.1 uc009cxv.2 uc009cxv.3 
ENSMUST00000041758.5 Cypt2 ENSMUST00000041758.5 cysteine-rich perinuclear theca 2 (from RefSeq NM_173436.2) Ckt1 Cypt2 Cypt2-ps ENSMUST00000041758.1 ENSMUST00000041758.2 ENSMUST00000041758.3 ENSMUST00000041758.4 NM_173436 Q6P924 Q6P924_MOUSE uc009uaz.1 uc009uaz.2 uc009uaz.3 uc009uaz.4 molecular_function cellular_component biological_process uc009uaz.1 uc009uaz.2 uc009uaz.3 uc009uaz.4 
ENSMUST00000041759.14 Hmgxb4 ENSMUST00000041759.14 HMG box domain containing 4, transcript variant 1 (from RefSeq NM_178017.3) ENSMUST00000041759.1 ENSMUST00000041759.10 ENSMUST00000041759.11 ENSMUST00000041759.12 ENSMUST00000041759.13 ENSMUST00000041759.2 ENSMUST00000041759.3 ENSMUST00000041759.4 ENSMUST00000041759.5 ENSMUST00000041759.6 ENSMUST00000041759.7 ENSMUST00000041759.8 ENSMUST00000041759.9 Hmgxb4 NM_178017 Q80Y32 Q80Y32_MOUSE uc009mgx.1 uc009mgx.2 uc009mgx.3 uc009mgx.4 DNA binding nucleus NURF complex uc009mgx.1 uc009mgx.2 uc009mgx.3 uc009mgx.4 
ENSMUST00000041763.14 4930505A04Rik ENSMUST00000041763.14 RIKEN cDNA 4930505A04 gene (from RefSeq NM_001100394.1) CB073_MOUSE ENSMUST00000041763.1 ENSMUST00000041763.10 ENSMUST00000041763.11 ENSMUST00000041763.12 ENSMUST00000041763.13 ENSMUST00000041763.2 ENSMUST00000041763.3 ENSMUST00000041763.4 ENSMUST00000041763.5 ENSMUST00000041763.6 ENSMUST00000041763.7 ENSMUST00000041763.8 ENSMUST00000041763.9 NM_001100394 Q5SPV6 Q810N4 Q9D580 uc007ihv.1 uc007ihv.2 uc007ihv.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SPV6-1; Sequence=Displayed; Name=2; IsoId=Q5SPV6-2; Sequence=VSP_033354; molecular_function cellular_component biological_process uc007ihv.1 uc007ihv.2 uc007ihv.3 
ENSMUST00000041767.14 Tbc1d2b ENSMUST00000041767.14 TBC1 domain family, member 2B, transcript variant 1 (from RefSeq NM_194334.3) ENSMUST00000041767.1 ENSMUST00000041767.10 ENSMUST00000041767.11 ENSMUST00000041767.12 ENSMUST00000041767.13 ENSMUST00000041767.2 ENSMUST00000041767.3 ENSMUST00000041767.4 ENSMUST00000041767.5 ENSMUST00000041767.6 ENSMUST00000041767.7 ENSMUST00000041767.8 ENSMUST00000041767.9 Kiaa1055 NM_194334 Q2VPQ4 Q3U0J8 Q6PHN8 Q6ZPZ5 TBD2B_MOUSE uc009rac.1 uc009rac.2 uc009rac.3 uc009rac.4 GTPase-activating protein that plays a role in the early steps of endocytosis. Early endosome Sequence=BAC98083.1; Type=Erroneous initiation; Evidence=; GTPase activator activity cytosol intracellular protein transport Rab GTPase binding activation of GTPase activity uc009rac.1 uc009rac.2 uc009rac.3 uc009rac.4 
ENSMUST00000041769.8 Dync1li2 ENSMUST00000041769.8 dynein, cytoplasmic 1 light intermediate chain 2 (from RefSeq NM_001013380.2) DC1L2_MOUSE Dncli2 Dnclic2 ENSMUST00000041769.1 ENSMUST00000041769.2 ENSMUST00000041769.3 ENSMUST00000041769.4 ENSMUST00000041769.5 ENSMUST00000041769.6 ENSMUST00000041769.7 NM_001013380 Q3UGJ3 Q6PDL0 uc009nao.1 uc009nao.2 uc009nao.3 uc009nao.4 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non- catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H. Cytoplasm, cytoskeleton Belongs to the dynein light intermediate chain family. nucleotide binding microtubule cytoskeleton organization kinetochore motor activity microtubule motor activity protein binding ATP binding cytoplasm lysosome late endosome centrosome cytoskeleton cytoplasmic dynein complex microtubule microtubule-based movement dynein complex dynein heavy chain binding protein homooligomerization centrosome localization cellular response to nerve growth factor stimulus uc009nao.1 uc009nao.2 uc009nao.3 uc009nao.4 
ENSMUST00000041776.12 Rgs8 ENSMUST00000041776.12 regulator of G-protein signaling 8, transcript variant 1 (from RefSeq NM_026380.3) ENSMUST00000041776.1 ENSMUST00000041776.10 ENSMUST00000041776.11 ENSMUST00000041776.2 ENSMUST00000041776.3 ENSMUST00000041776.4 ENSMUST00000041776.5 ENSMUST00000041776.6 ENSMUST00000041776.7 ENSMUST00000041776.8 ENSMUST00000041776.9 NM_026380 Q505F2 Q8BXT1 RGS8_MOUSE uc007dad.1 uc007dad.2 uc007dad.3 Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling. Interacts with GNAO1 and GNAI3. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane ; Peripheral membrane protein ; Cytoplasmic side Perikaryon Cell projection, dendrite Nucleus Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1. G-protein alpha-subunit binding GTPase activator activity nucleus plasma membrane G-protein coupled receptor signaling pathway G-protein coupled acetylcholine receptor signaling pathway negative regulation of signal transduction membrane dendrite extrinsic component of cytoplasmic side of plasma membrane neuronal cell body membrane cell projection perikaryon positive regulation of GTPase activity regulation of dopamine receptor signaling pathway uc007dad.1 uc007dad.2 uc007dad.3 
ENSMUST00000041778.8 Zfp174 ENSMUST00000041778.8 zinc finger protein 174, transcript variant 1 (from RefSeq NM_001081217.2) B9EJW5 B9EJW5_MOUSE ENSMUST00000041778.1 ENSMUST00000041778.2 ENSMUST00000041778.3 ENSMUST00000041778.4 ENSMUST00000041778.5 ENSMUST00000041778.6 ENSMUST00000041778.7 NM_001081217 Zfp174 uc007xyt.1 uc007xyt.2 uc007xyt.3 Nucleus negative regulation of transcription from RNA polymerase II promoter nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytoplasm cytosol plasma membrane regulation of transcription, DNA-templated actin cytoskeleton protein homodimerization activity sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated metal ion binding uc007xyt.1 uc007xyt.2 uc007xyt.3 
ENSMUST00000041779.13 Clec4a2 ENSMUST00000041779.13 C-type lectin domain family 4, member a2, transcript variant 2 (from RefSeq NM_011999.5) CLC4A_MOUSE Clec4a Clecsf6 Dcir ENSMUST00000041779.1 ENSMUST00000041779.10 ENSMUST00000041779.11 ENSMUST00000041779.12 ENSMUST00000041779.2 ENSMUST00000041779.3 ENSMUST00000041779.4 ENSMUST00000041779.5 ENSMUST00000041779.6 ENSMUST00000041779.7 ENSMUST00000041779.8 ENSMUST00000041779.9 NM_011999 Q4VA33 Q9QZ15 uc009dqb.1 uc009dqb.2 uc009dqb.3 May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production (By similarity). May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation (PubMed:11841542). May interact with PTPN6 via its ITIM site. Cell membrane ; Single-pass type II membrane protein ; Extracellular side Expressed in splenic antigen-presenting cells including B-cells, monocytes/macrophages, and dendritic cells (at protein level). Expressed in spleen and lymph node and slightly increased with dendritic cell maturation. Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Name=Functional Glycomics Gateway - Glycan Binding; Note=DCIR1; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_160"; negative regulation of cytokine production adaptive immune response immune system process plasmacytoid dendritic cell antigen processing and presentation calcium ion binding mannose binding plasma membrane membrane integral component of membrane carbohydrate binding negative regulation of tumor necrosis factor production CD8-positive, alpha-beta T cell activation antigen processing and presentation of exogenous peptide antigen via MHC class I innate immune response metal ion binding uc009dqb.1 uc009dqb.2 uc009dqb.3 
ENSMUST00000041782.4 Abt1 ENSMUST00000041782.4 activator of basal transcription 1 (from RefSeq NM_013924.3) ABT1_MOUSE ENSMUST00000041782.1 ENSMUST00000041782.2 ENSMUST00000041782.3 NM_013924 Q0VGU7 Q9D762 Q9QYL7 uc007pto.1 uc007pto.2 Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes. Interacts with ESF1/ABTAP. Interacts with IGHMBP2. Nucleus Nucleus, nucleolus Ubiquitously expressed. Belongs to the ESF2/ABP1 family. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleic acid binding DNA binding RNA binding nucleus transcription factor complex nucleolus regulation of transcription from RNA polymerase II promoter spinal cord motor neuron differentiation small-subunit processome assembly uc007pto.1 uc007pto.2 
ENSMUST00000041783.14 Iqce ENSMUST00000041783.14 IQ motif containing E, transcript variant 1 (from RefSeq NM_028833.3) ENSMUST00000041783.1 ENSMUST00000041783.10 ENSMUST00000041783.11 ENSMUST00000041783.12 ENSMUST00000041783.13 ENSMUST00000041783.2 ENSMUST00000041783.3 ENSMUST00000041783.4 ENSMUST00000041783.5 ENSMUST00000041783.6 ENSMUST00000041783.7 ENSMUST00000041783.8 ENSMUST00000041783.9 IQCE_MOUSE NM_028833 Q6PCQ0 Q8CDZ1 Q9D9U3 uc009ahx.1 uc009ahx.2 uc009ahx.3 Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:24582806). Required for proper limb morphogenesis (By similarity). Component of the EvC complex composed of EFCAB7, IQCE, EVC2 and EVC; built from two subcomplexes, EVC2:EVC and EFCAB7:IQCE (PubMed:24582806). Interacts (via N-terminus) with EFCAB7 (via EF-hands 1 and 2); this interaction anchors the EVC-EVC2 complex in a signaling microdomain at the base of cilia and stimulates the Hedgehog (Hh) pathway. Interacts with EVC2 (via N-terminal end) (PubMed:24582806). Interacts with EVC (PubMed:24582806). Cell projection, cilium membrane ; Peripheral membrane protein ; Cytoplasmic side Note=The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner (PubMed:24582806). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PCQ0-1; Sequence=Displayed; Name=2; IsoId=Q6PCQ0-2; Sequence=VSP_024436, VSP_024439; Name=3; IsoId=Q6PCQ0-3; Sequence=VSP_024436, VSP_024437, VSP_024438; protein binding mitochondrion plasma membrane membrane extrinsic component of membrane limb morphogenesis cell projection positive regulation of transcription from RNA polymerase II promoter ciliary membrane plasma membrane protein complex uc009ahx.1 uc009ahx.2 uc009ahx.3 
ENSMUST00000041804.8 Lmtk2 ENSMUST00000041804.8 lemur tyrosine kinase 2 (from RefSeq NM_001081109.2) A6BLY9 Brek ENSMUST00000041804.1 ENSMUST00000041804.2 ENSMUST00000041804.3 ENSMUST00000041804.4 ENSMUST00000041804.5 ENSMUST00000041804.6 ENSMUST00000041804.7 Kiaa1079 LMTK2_MOUSE NM_001081109 Q3TYD6 Q6PDK6 Q6ZPY9 Q8CA34 uc009alg.1 uc009alg.2 Phosphorylates PPP1C, phosphorylase b and CFTR. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts with PPP1C and inhibitor-2. Membrane ; Multi-pass membrane protein. Mainly expressed in brain, especially in the olfactory bulb, olfactory tubercle, hippocampus, striatum, cerebellum and cerebral cortex. Weakly expressed in skeletal muscle and not expressed in liver. Expression observed during all tested stages from 18 dpc to postnatal week 6, but it was especially high during the early postnatal stage (postnatal weeks 0-2). Autophosphorylated. Phosphorylated (By similarity). Belongs to the protein kinase superfamily. Tyr protein kinase family. nucleotide binding receptor recycling protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein tyrosine kinase activity protein phosphatase inhibitor activity ATP binding cytoplasm early endosome Golgi apparatus cytosol integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway nervous system development axon guidance membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation growth cone endocytic recycling negative regulation of phosphoprotein phosphatase activity transferrin transport neuronal cell body receptor complex early endosome to late endosome transport protein autophosphorylation neurotrophin TRK receptor signaling pathway perinuclear region of cytoplasm recycling endosome myosin VI binding uc009alg.1 uc009alg.2 
ENSMUST00000041806.13 Psen1 ENSMUST00000041806.13 presenilin 1 (from RefSeq NM_001362271.1) ENSMUST00000041806.1 ENSMUST00000041806.10 ENSMUST00000041806.11 ENSMUST00000041806.12 ENSMUST00000041806.2 ENSMUST00000041806.3 ENSMUST00000041806.4 ENSMUST00000041806.5 ENSMUST00000041806.6 ENSMUST00000041806.7 ENSMUST00000041806.8 ENSMUST00000041806.9 NM_001362271 Psen1 Q3UYK2 Q3UYK2_MOUSE uc007odp.1 uc007odp.2 uc007odp.3 Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Homodimer. Cell projection, axon Cell projection, neuron projection Cytoplasmic granule Early endosome membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Synapse The PAL motif is required for normal active site conformation. Belongs to the peptidase A22A family. negative regulation of transcription from RNA polymerase II promoter Golgi membrane kinetochore astrocyte activation involved in immune response neural retina development endopeptidase activity aspartic-type endopeptidase activity calcium channel activity nucleus nuclear outer membrane cytoplasm mitochondrion mitochondrial inner membrane lysosomal membrane early endosome endoplasmic reticulum endoplasmic reticulum membrane smooth endoplasmic reticulum rough endoplasmic reticulum Golgi apparatus centrosome plasma membrane integral component of plasma membrane proteolysis membrane protein ectodomain proteolysis Notch signaling pathway learning or memory memory beta-catenin binding synaptic vesicle peptidase activity cell surface positive regulation of gene expression negative regulation of gene expression regulation of neuron projection development membrane integral component of membrane aggresome protein processing hydrolase activity cerebellum development cell junction PDZ domain binding growth cone neuromuscular junction nuclear membrane positive regulation of protein binding endoplasmic reticulum calcium ion homeostasis macromolecular complex beta-amyloid formation intracellular signal transduction positive regulation of protein import into nucleus regulation of phosphorylation positive regulation of phosphorylation sarcolemma aspartic endopeptidase activity, intramembrane cleaving positive regulation of tumor necrosis factor biosynthetic process amyloid precursor protein metabolic process amyloid precursor protein catabolic process neuron projection negative regulation of apoptotic process positive regulation of catalytic activity negative regulation of neuron apoptotic process membrane raft synapse positive regulation of glycolytic process positive regulation of transcription, DNA-templated astrocyte activation synapse organization positive regulation of dendritic spine development calcium ion transmembrane transport gamma-secretase complex modulation of age-related behavioral decline synaptic membrane cell-cell adhesion integral component of presynaptic membrane cellular response to beta-amyloid negative regulation of core promoter binding neuron projection maintenance uc007odp.1 uc007odp.2 uc007odp.3 
ENSMUST00000041815.15 Tsga10 ENSMUST00000041815.15 testis specific 10, transcript variant 1 (from RefSeq NM_207228.3) ENSMUST00000041815.1 ENSMUST00000041815.10 ENSMUST00000041815.11 ENSMUST00000041815.12 ENSMUST00000041815.13 ENSMUST00000041815.14 ENSMUST00000041815.2 ENSMUST00000041815.3 ENSMUST00000041815.4 ENSMUST00000041815.5 ENSMUST00000041815.6 ENSMUST00000041815.7 ENSMUST00000041815.8 ENSMUST00000041815.9 NM_207228 Q68RJ4 Q6NY15 Q8K3V2 TSG10_MOUSE uc007arz.1 uc007arz.2 uc007arz.3 uc007arz.4 Plays a role in spermatogenesis (PubMed:14585816). When overexpressed, prevents nuclear localization of HIF1A (PubMed:16777103). Interacts with HIF1A. Q6NY15; Q61221-1: Hif1a; NbExp=2; IntAct=EBI-8549230, EBI-8549331; Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=In mature spermatozoa, localizes to the centriole and midpiece (By similarity). The 27-kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail, while the 55-kDa peptide localizes to the midpiece (PubMed:16643851, PubMed:16777103). Detected in the cytoplasm of almost all spermatogonial cells within the seminiferous tubules (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6NY15-1; Sequence=Displayed; Name=2; IsoId=Q6NY15-2; Sequence=VSP_028580; Name=3; IsoId=Q6NY15-3; Sequence=VSP_028579, VSP_028580; Predominantly expressed in testis, in spermatozoa (at protein level) (PubMed:14585816, PubMed:16643851). Not detected in Leydig cells (PubMed:16643851). The N-terminal 27-kDa fragment is also detected in liver, while the C-terminal 55-kDa fragment is also found retina, brain and kidney (at protein level) (PubMed:16643851). First detected at 7.5 dpc (PubMed:16643851). Tends to be expressed weakly during the early stages of embryogenesis. Expression increases over time in different growing and differentiating tissues, including brain (11.5 dpc), vertebrae (14.5 dpc), primordia of vibrissae follicle (15.5 dpc), intestinal sub-endothelium (16.5 dpc), pancreas (16.5 dpc), eyeball (16.5 dpc), liver (16.5 dpc), telencephalon (18.5 dpc) (PubMed:16643851). In the developing neural tube at 8.5-9.0 dpc, preferentially expressed in cells with one or more neuronal extensions (PubMed:16643851). During spermatogenesis, weakly detected in primary spermatocytes, but expression increases, reaching strong levels in elongated spermatids (stage V) and mature sperm (at protein level) (PubMed:16643851). Processed into N-terminal 27-kDa and C-terminal 55-kDa fragments. Belongs to the CEP135/TSGA10 family. structural molecule activity protein binding cytoplasm centriole cytoskeleton spermatogenesis cell projection assembly motile cilium sperm fibrous sheath neuron projection sperm principal piece uc007arz.1 uc007arz.2 uc007arz.3 uc007arz.4 
ENSMUST00000041826.14 Rnf13 ENSMUST00000041826.14 ring finger protein 13, transcript variant 6 (from RefSeq NM_001357080.1) ENSMUST00000041826.1 ENSMUST00000041826.10 ENSMUST00000041826.11 ENSMUST00000041826.12 ENSMUST00000041826.13 ENSMUST00000041826.2 ENSMUST00000041826.3 ENSMUST00000041826.4 ENSMUST00000041826.5 ENSMUST00000041826.6 ENSMUST00000041826.7 ENSMUST00000041826.8 ENSMUST00000041826.9 NM_001357080 O54965 O54966 Q6PEA8 RNF13_MOUSE Rzf uc008phj.1 uc008phj.2 uc008phj.3 uc008phj.4 uc008phj.5 This gene encodes a member of the PA-TM-RING family of proteins that contain a protease associated (PA) domain and a RING finger domain separated by a transmembrane (TM) domain. The encoded protein is an E3 ubiquitin ligase localized to the endosomal-lysosomal vesicles and inner nuclear membrane. Mice lacking the encoded protein have impaired learning abilities associated with a decreased synaptic vesicle density and dysregulated SNARE complex assembly. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on the X chromosome. [provided by RefSeq, Jan 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.149878.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:19292867). Involved in apoptosis regulation (By similarity). Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (By similarity). Also involved in protein trafficking and localization (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with ERN1. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Late endosome membrane ; Single-pass type I membrane protein Lysosome membrane ; Single-pass type I membrane protein Nucleus inner membrane ; Single-pass type I membrane protein Note=The mature protein is subjected to extensive proteolysis that leads to the shedding of the ectodomain into the lumen of vesicles and the release of the C-terminal fragment into the cytosol (PubMed:20230530). Not detected in early endosomes (PubMed:20230530). Treatment of the cells with either PMA or ionomycin stabilizes the full-length protein which relocalizes to recycling endosomes and to the inner nuclear membrane (PubMed:20230530). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O54965-1; Sequence=Displayed; Name=2; IsoId=O54965-2; Sequence=VSP_005749, VSP_005750; Expressed in the brain, heart, kidney, liver and spleen. Higher expression in adult tissues compared to the embryonic counterparts. The RING-type zinc finger domain is required for E3 ligase activity and for promoting ER stress-induced JNK activation and apoptosis. Autoubiquitinated. N-glycosylated and also modified with chondroitin sulfate. ubiquitin-protein transferase activity nucleus nuclear inner membrane nucleoplasm cytoplasm lysosome lysosomal membrane endosome endoplasmic reticulum cytosol ubiquitin-dependent protein catabolic process JUN kinase binding membrane integral component of membrane protein ubiquitination transferase activity late endosome membrane intracellular membrane-bounded organelle metal ion binding protein autoubiquitination ubiquitin protein ligase activity positive regulation of stress-activated protein kinase signaling cascade uc008phj.1 uc008phj.2 uc008phj.3 uc008phj.4 uc008phj.5 
ENSMUST00000041827.8 Slc22a20 ENSMUST00000041827.8 solute carrier family 22 (organic anion transporter), member 20 (from RefSeq NM_198650.2) ENSMUST00000041827.1 ENSMUST00000041827.2 ENSMUST00000041827.3 ENSMUST00000041827.4 ENSMUST00000041827.5 ENSMUST00000041827.6 ENSMUST00000041827.7 Gm963 NM_198650 Oat6 Q5JBT1 Q80UJ1 S22AK_MOUSE uc008ggh.1 uc008ggh.2 Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2-methylbutyrate, 3- methylbutyrate, benzoate, heptanoate and 2-ethylhaxanoate. May act as an odorant transporter. Kinetic parameters: KM=109.8 uM for estrone sulfate Vmax=40 pmol/h/mg enzyme for ES uptake Vmax=4.6 pmol/h/mg enzyme for PAH uptake Vmax=0.9 pmol/h/mg enzyme for prostaglandin E2 uptake Vmax=0.28 pmol/h/mg enzyme for ibuprofen uptake Vmax=4.8 pmol/h/mg enzyme for ochratoxin A uptake Vmax=5.1 pmol/h/mg enzyme for fluorescein uptake Vmax=2.1 pmol/h/mg enzyme for 2-carboxyfluorescein-DM uptake Vmax=3.9 pmol/h/mg enzyme for eosin-Y uptake Membrane ; Multi-pass membrane protein Highly expressed in olfactory mucosa. Weakly expressed in testis. Not detected in heart, spleen, lung, kidney or brain. Expressed at embryonic day 7, but not later in embryogenesis. Expressed in adult. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. ion transport organic anion transmembrane transporter activity organic anion transport membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008ggh.1 uc008ggh.2 
ENSMUST00000041830.10 Ntmt1 ENSMUST00000041830.10 N-terminal Xaa-Pro-Lys N-methyltransferase 1, transcript variant 1 (from RefSeq NM_170592.3) A2APZ4 ENSMUST00000041830.1 ENSMUST00000041830.2 ENSMUST00000041830.3 ENSMUST00000041830.4 ENSMUST00000041830.5 ENSMUST00000041830.6 ENSMUST00000041830.7 ENSMUST00000041830.8 ENSMUST00000041830.9 Mettl11a NM_170592 NTM1A_MOUSE Q8R2U4 uc008jcv.1 uc008jcv.2 uc008jcv.3 Distributive alpha-N-methyltransferase that methylates the N- terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]- Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (PubMed:20668449). Some of the substrates may be primed by NTMT2- mediated monomethylation. Catalyzes the trimethylation of the N- terminal Gly in CENPA (after removal of Met-1) (By similarity). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1 (PubMed:20668449). Reaction=N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl- L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl- L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54712, Rhea:RHEA-COMP:13785, Rhea:RHEA-COMP:13971, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138057, ChEBI:CHEBI:138315; EC=2.1.1.244; Evidence=; Reaction=N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl- L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl- L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54724, Rhea:RHEA-COMP:13789, Rhea:RHEA-COMP:13973, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138061, ChEBI:CHEBI:138317; EC=2.1.1.244; Evidence=; Reaction=N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl- L-methionine = 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L- lysyl-[protein] + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54736, Rhea:RHEA-COMP:13787, Rhea:RHEA-COMP:13974, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138059, ChEBI:CHEBI:138318; EC=2.1.1.244; Evidence=; Nucleus Note=Predominantly nuclear. Belongs to the methyltransferase superfamily. NTM1 family. nucleus nucleoplasm cytoplasm cytosol N-terminal protein amino acid methylation spindle organization chromosome segregation methyltransferase activity protein methyltransferase activity histone methylation transferase activity N-terminal peptidyl-alanine trimethylation N-terminal peptidyl-glycine methylation N-terminal peptidyl-proline dimethylation methylation N-terminal peptidyl-serine dimethylation N-terminal peptidyl-serine trimethylation histone methyltransferase activity N-terminal protein N-methyltransferase activity uc008jcv.1 uc008jcv.2 uc008jcv.3 
ENSMUST00000041840.14 Spef2 ENSMUST00000041840.14 sperm flagellar 2, transcript variant 2 (from RefSeq NM_177123.4) A2RSG5 E0CYG3 ENSMUST00000041840.1 ENSMUST00000041840.10 ENSMUST00000041840.11 ENSMUST00000041840.12 ENSMUST00000041840.13 ENSMUST00000041840.2 ENSMUST00000041840.3 ENSMUST00000041840.4 ENSMUST00000041840.5 ENSMUST00000041840.6 ENSMUST00000041840.7 ENSMUST00000041840.8 ENSMUST00000041840.9 G0Z098 Kpl2 NM_177123 Q8C9J3 SPEF2_MOUSE uc007vfq.1 uc007vfq.2 uc007vfq.3 Required for correct axoneme development in spermatozoa (PubMed:21715716, PubMed:28619825). Important for normal development of the manchette and sperm head morphology (PubMed:28619825). Essential for male fertility (PubMed:21715716, PubMed:28619825). Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation (PubMed:28619825). Interacts (via C-terminus) with IFT20 (PubMed:19889948). Interacts with DYNC1I2 (PubMed:28619825). Cell projection, cilium, flagellum Cytoplasm Cytoplasm, cytoskeleton Golgi apparatus Note=Shows dynamic localization in developing spermatozoa (PubMed:19889948). Localizes to the manchette in step 10-12 elongating spermatids, where it is mainly found on the basal side below the perinuclear ring (PubMed:19889948, PubMed:28619825). Detected in the basal body and neck area of step 13- 14 spermatids (PubMed:19889948). Localizes to the midpiece of the sperm tail in step 15-16 spermatids (PubMed:19889948). During the epididymal transport of spermatozoa, expression in the sperm tail reduces and becomes concentrated at the distal part of the midpiece (PubMed:19889948). Detected in the Golgi apparatus of late spermatocytes and round spermatids (PubMed:19889948). Detected in the cytoplasm of Sertoli cells (PubMed:19889948). Event=Alternative splicing; Named isoforms=4; Comment=A number of isoforms are produced. ; Name=1; IsoId=Q8C9J3-1; Sequence=Displayed; Name=2; IsoId=Q8C9J3-2; Sequence=VSP_027528, VSP_027529; Name=3; IsoId=Q8C9J3-3; Sequence=VSP_027526, VSP_027527; Name=4; IsoId=Q8C9J3-4; Sequence=VSP_059848, VSP_059849; Highly expressed in testis, where it primarily localizes to late spermatocytes, round spermatids and elongating spermatids (at protein level) (PubMed:19889948, PubMed:29339787). Found in Sertoli cells of the testis (at protein level) (PubMed:19889948). Expressed at lower levels in epididymis (at protein level) (PubMed:19889948, PubMed:29339787). Detected in lung, brain, liver and kidney (PubMed:19889948, PubMed:29339787). Also detected in bone, cartilage, trachea, pituitary gland and eye (PubMed:29339787). Expressed in osteoblasts and chondrocytes (PubMed:29339787). Shows increasing expression levels in testis during postnatal stages, reaching highest levels by postnatal day 50. In testis, first detected in pachytene spermatocytes (stage VII), reaching peak expression in meitotically dividing spermatocytes (stage XII). Lethality occurs at approximately 3 weeks of age, accompanied by severe hydrocephaly. Weight at birth is similar to wild type but subsequently there is significant growth retardation. Bone mineralization is reduced in the vertebral column and hindlimbs, associated with decreased bone strength. Bone length and skull thickness is also slightly reduced. Trabecular bone density is reduced, along with reduced trabecular number and increased open porosity. Expression of the osteoblast marker genes RUNX2, BGLAP/OCN and COL1A1/COL1 is reduced in bone tissue. Expression of SP7/OSX and ALPL is also reduced in cultured calvarial osteoblasts. Osteoclast differentiation does not appear to be affected. No obvious effects on cilia length or axonemal structure. manchette epithelial cilium movement protein binding extracellular region cytoplasm Golgi apparatus cytoskeleton spermatogenesis sperm axoneme assembly cell differentiation skeletal system morphogenesis brain morphogenesis respiratory system development sperm midpiece uc007vfq.1 uc007vfq.2 uc007vfq.3 
ENSMUST00000041852.8 Pyroxd1 ENSMUST00000041852.8 pyridine nucleotide-disulphide oxidoreductase domain 1, transcript variant 7 (from RefSeq NR_177441.1) ENSMUST00000041852.1 ENSMUST00000041852.2 ENSMUST00000041852.3 ENSMUST00000041852.4 ENSMUST00000041852.5 ENSMUST00000041852.6 ENSMUST00000041852.7 NR_177441 PYRD1_MOUSE Q3TMV7 Q3UFM2 Q8R2X5 uc009epc.1 uc009epc.2 uc009epc.3 Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (By similarity). Required for normal sarcomere structure and muscle fiber integrity (By similarity). Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Nucleus Cytoplasm Cytoplasm, myofibril, sarcomere Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily. molecular_function nucleus cytoplasm oxidoreductase activity sarcomere cellular response to oxidative stress oxidation-reduction process uc009epc.1 uc009epc.2 uc009epc.3 
ENSMUST00000041859.9 Gmds ENSMUST00000041859.9 GDP-mannose 4, 6-dehydratase (from RefSeq NM_146041.2) ENSMUST00000041859.1 ENSMUST00000041859.2 ENSMUST00000041859.3 ENSMUST00000041859.4 ENSMUST00000041859.5 ENSMUST00000041859.6 ENSMUST00000041859.7 ENSMUST00000041859.8 GMDS_MOUSE NM_146041 Q8K0C9 uc007pzq.1 uc007pzq.2 uc007pzq.3 Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. Reaction=GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O; Xref=Rhea:RHEA:23820, ChEBI:CHEBI:15377, ChEBI:CHEBI:57527, ChEBI:CHEBI:57964; EC=4.2.1.47; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23821; Evidence=; Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence=; Inhibited by GDP-fucose. Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2. Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. cytoplasm Notch signaling pathway GDP-mannose 4,6-dehydratase activity lyase activity GDP-mannose metabolic process 'de novo' GDP-L-fucose biosynthetic process identical protein binding NADP+ binding uc007pzq.1 uc007pzq.2 uc007pzq.3 
ENSMUST00000041860.13 Gdpd4 ENSMUST00000041860.13 glycerophosphodiester phosphodiesterase domain containing 4 (from RefSeq NM_177696.3) ENSMUST00000041860.1 ENSMUST00000041860.10 ENSMUST00000041860.11 ENSMUST00000041860.12 ENSMUST00000041860.2 ENSMUST00000041860.3 ENSMUST00000041860.4 ENSMUST00000041860.5 ENSMUST00000041860.6 ENSMUST00000041860.7 ENSMUST00000041860.8 ENSMUST00000041860.9 GDPD4_MOUSE Gde6 NM_177696 Q3TT99 Q8BI25 uc012fpl.1 uc012fpl.2 uc012fpl.3 Cytoplasm Membrane ; Multi-pass membrane protein Detected in testis, in particular in spermatocytes. Belongs to the glycerophosphoryl diester phosphodiesterase family. Sequence=BAC26496.1; Type=Frameshift; Evidence=; molecular_function cellular_component cytoplasm lipid metabolic process phosphoric diester hydrolase activity biological_process membrane integral component of membrane hydrolase activity metal ion binding uc012fpl.1 uc012fpl.2 uc012fpl.3 
ENSMUST00000041865.8 Nostrin ENSMUST00000041865.8 nitric oxide synthase trafficker (from RefSeq NM_181547.3) Daip2 ENSMUST00000041865.1 ENSMUST00000041865.2 ENSMUST00000041865.3 ENSMUST00000041865.4 ENSMUST00000041865.5 ENSMUST00000041865.6 ENSMUST00000041865.7 NM_181547 NOSTN_MOUSE Nostrin Q6WKZ7 Q7TSK5 Q8BWC2 uc008jxt.1 uc008jxt.2 uc008jxt.3 uc008jxt.4 Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. Homotrimer. Interacts with NOS3, DNM2, WASL and CAV1 (By similarity). Interacts with DAB2. Interacts (via SH3 domain) with DNM2; this interaction allows the recruitment of NOS3 to dynamin-positive structures (By similarity). Q6WKZ7; P98078: Dab2; NbExp=2; IntAct=EBI-1391878, EBI-1391846; Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle Cytoplasm, cytoskeleton Cytoplasm Nucleus Note=Enriched in selected actin structures. In F9 cells, by retinoic acid (at protein level). The SH3 domain mediates interaction with NOS3, DNM2 and WASL. The F-BAR domain is necessary for membrane targeting. Seems to repress its own transcription. DNA binding protein binding nucleus cytoplasm cytoskeleton plasma membrane endocytosis membrane nuclear speck cytoplasmic vesicle negative regulation of transcription, DNA-templated uc008jxt.1 uc008jxt.2 uc008jxt.3 uc008jxt.4 
ENSMUST00000041871.9 Tbx10 ENSMUST00000041871.9 T-box 10, transcript variant 2 (from RefSeq NM_011533.2) ENSMUST00000041871.1 ENSMUST00000041871.2 ENSMUST00000041871.3 ENSMUST00000041871.4 ENSMUST00000041871.5 ENSMUST00000041871.6 ENSMUST00000041871.7 ENSMUST00000041871.8 NM_011533 O54841 Q32MF8 Q6QH75 Q810F8 TBX10_MOUSE Tbx13 Tbx7 uc008fya.1 uc008fya.2 uc008fya.3 uc008fya.4 Probable transcriptional regulator involved in developmental processes. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q810F8-1; Sequence=Displayed; Name=2; IsoId=Q810F8-2; Sequence=VSP_011305; Note=Defects in Tbx10 are the cause of a cleft lip and palate (CL/P) phenotype called Dancer (Dc). The defect is caused by a gain of function. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cell fate specification DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc008fya.1 uc008fya.2 uc008fya.3 uc008fya.4 
ENSMUST00000041874.9 Npl ENSMUST00000041874.9 N-acetylneuraminate pyruvate lyase (from RefSeq NM_028749.1) ENSMUST00000041874.1 ENSMUST00000041874.2 ENSMUST00000041874.3 ENSMUST00000041874.4 ENSMUST00000041874.5 ENSMUST00000041874.6 ENSMUST00000041874.7 ENSMUST00000041874.8 NM_028749 NPL_MOUSE Npl Q9DCJ9 uc007dac.1 uc007dac.2 uc007dac.3 Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Reaction=aceneuramate = N-acetyl-D-mannosamine + pyruvate; Xref=Rhea:RHEA:23296, ChEBI:CHEBI:15361, ChEBI:CHEBI:17122, ChEBI:CHEBI:173083; EC=4.1.3.3; Evidence=; Amino-sugar metabolism; N-acetylneuraminate degradation. Homotetramer. Cytoplasm Belongs to the DapA family. NanA subfamily. catalytic activity cellular_component cytoplasm carbohydrate metabolic process N-acetylneuraminate lyase activity lyase activity N-acetylneuraminate catabolic process identical protein binding uc007dac.1 uc007dac.2 uc007dac.3 
ENSMUST00000041882.7 Fam174c ENSMUST00000041882.7 family with sequence similarity 174, member C (from RefSeq NM_027207.2) ENSMUST00000041882.1 ENSMUST00000041882.2 ENSMUST00000041882.3 ENSMUST00000041882.4 ENSMUST00000041882.5 ENSMUST00000041882.6 F174C_MOUSE NM_027207 Q3THR0 Q9DAZ5 uc007gcf.1 uc007gcf.2 uc007gcf.3 Membrane ; Single-pass type I membrane protein Belongs to the FAM174 family. molecular_function extracellular region cytoplasm biological_process membrane integral component of membrane uc007gcf.1 uc007gcf.2 uc007gcf.3 
ENSMUST00000041890.8 Tm6sf1 ENSMUST00000041890.8 transmembrane 6 superfamily member 1, transcript variant 1 (from RefSeq NM_145375.4) ENSMUST00000041890.1 ENSMUST00000041890.2 ENSMUST00000041890.3 ENSMUST00000041890.4 ENSMUST00000041890.5 ENSMUST00000041890.6 ENSMUST00000041890.7 NM_145375 P58749 Q8BUN7 TM6S1_MOUSE uc009icp.1 uc009icp.2 uc009icp.3 uc009icp.4 uc009icp.5 May function as sterol isomerase. Lysosome membrane ; Multi-pass membrane protein Broad expression. Belongs to the TM6SF family. lysosome lysosomal membrane membrane integral component of membrane uc009icp.1 uc009icp.2 uc009icp.3 uc009icp.4 uc009icp.5 
ENSMUST00000041892.13 Wdr19 ENSMUST00000041892.13 WD repeat domain 19, transcript variant 2 (from RefSeq NM_153391.2) ENSMUST00000041892.1 ENSMUST00000041892.10 ENSMUST00000041892.11 ENSMUST00000041892.12 ENSMUST00000041892.2 ENSMUST00000041892.3 ENSMUST00000041892.4 ENSMUST00000041892.5 ENSMUST00000041892.6 ENSMUST00000041892.7 ENSMUST00000041892.8 ENSMUST00000041892.9 Ift144 Kiaa1638 NM_153391 Q3UGF1 Q6ZPK8 Q80VQ6 Q8C794 Q8K3R5 WDR19_MOUSE Wdr19 uc008xnh.1 uc008xnh.2 uc008xnh.3 As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in cilia function and/or assembly (Probable). Essential for functional IFT-A assembly and ciliary entry of GPCRs (By similarity). Associates with the BBSome complex to mediate ciliary transport (PubMed:22922713). Component of the IFT complex A (IFT-A) complex. IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B (By similarity). Interacts (via C-terminal region) with IFT122 (via C-terminal region) (By similarity). Interacts with BBS1 (PubMed:22922713). Interacts with TTC25 (PubMed:25860617). Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Cell projection, cilium, photoreceptor outer segment Cell projection, cilium, flagellum Note=Localizes to photoreceptor connecting cilia, to the base of motile cilia in brain ependymal cells and to the base of and along primary cilia in cultured kidney inner mnedullary collecting duct (IMCD) cells. Localizes at the sperm neck and flagellum (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UGF1-1; Sequence=Displayed; Name=2; IsoId=Q3UGF1-2; Sequence=VSP_018075; Name=3; IsoId=Q3UGF1-3; Sequence=VSP_018076, VSP_018077; Tissue-specific expression of isoforms (PubMed:12906858). Expressed in the prostate, testis, epididymis, submaxillary and salivary glands (PubMed:12906858). Expressed in ependymal cells lining brain ventricles (at protein level) (PubMed:16957054). Sequence=AAH46432.1; Type=Frameshift; Evidence=; cell morphogenesis in utero embryonic development photoreceptor outer segment molecular_function nucleoplasm cytoplasm cytoskeleton cilium smoothened signaling pathway gonad development nuclear body cell projection organization embryonic limb morphogenesis intraciliary transport particle A embryonic camera-type eye development motile cilium photoreceptor connecting cilium intraciliary retrograde transport ear morphogenesis cell projection embryonic cranial skeleton morphogenesis neurological system process digestive system development cilium assembly ciliary receptor clustering involved in smoothened signaling pathway smoothened signaling pathway involved in dorsal/ventral neural tube patterning myotome development protein localization to cilium macromolecular complex assembly non-motile cilium protein localization to ciliary membrane uc008xnh.1 uc008xnh.2 uc008xnh.3 
ENSMUST00000041901.7 Cib2 ENSMUST00000041901.7 calcium and integrin binding family member 2 (from RefSeq NM_019686.6) CIB2_MOUSE ENSMUST00000041901.1 ENSMUST00000041901.2 ENSMUST00000041901.3 ENSMUST00000041901.4 ENSMUST00000041901.5 ENSMUST00000041901.6 Kip2 NM_019686 Q9Z309 uc009prf.1 uc009prf.2 uc009prf.3 Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis (PubMed:23023331, PubMed:29084757, PubMed:29255404, PubMed:28663585, PubMed:34089643). Acts as an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells (PubMed:34089643). Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing (PubMed:29084757, PubMed:29255404, PubMed:28663585). Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells (PubMed:34089643). Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (PubMed:29084757, PubMed:29255404, PubMed:28663585). Critical for proper photoreceptor cell maintenance and function (PubMed:23023331). Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release (PubMed:23023331). Seems to be dispensable for vestibular functions (PubMed:29084757). Monomer (By similarity). Homodimer (By similarity). Interacts with WHRN and MYO7A (By similarity). Interacts with ITGA2B (via C- terminus cytoplasmic tail region); this interaction is stabilized/increased in a calcium and magnesium-dependent manner (PubMed:18611855). Interacts with ITGA7 (via C-terminus cytoplasmic tail region); this interaction is stabilized/increased in a calcium and magnesium-dependent manner (PubMed:18989529). Interacts with TMC1 (PubMed:28663585, PubMed:34089643). Interacts with TMC2 (PubMed:28663585). Cytoplasm Cell projection, stereocilium otoreceptor inner segment Cell projection, cilium, photoreceptor outer segment Cell membrane, sarcolemma Note=Colocalizes with ITGA7 at the myotendinous junctions (MTJ) and at the neuromuscular junctions (NMJ) (PubMed:18611855). Located mainly in stereocilia and at the apical surface of hair cells of the cochlea (PubMed:29084757). Localizes in the cuticular plate along and at the tip of the stereocilia of vestibular sensory hair cells (By similarity). Expressed in inner and outer segments of photoreceptor cells, as well as in the pigmented epithelium. Also observed in the inner and outer plexiform layers and in the ganglion cell layer (at protein level) (PubMed:23023331). Expressed in sensory hair cell stereocilia, with expression mainly at the basal body of the kinocilium and in the hair bundle stereocilia; and the apical surface of hair cells (at protein level) (PubMed:29084757). Located in the tip region of the stereocilia and at the apical surface of hair cells around the cuticular plate (at protein level) (PubMed:29084757). Not expressed in the hair bundles of the vestibular hair cells (PubMed:29084757). Strongly expressed in skeletal muscles, brain, kidney and liver (PubMed:23023331, PubMed:29255404). Expressed in the skeletal muscle, retina and cochlea (PubMed:18611855, PubMed:23023331). Expressed in megakaryocytes and endothelial cells (PubMed:18989529). Expressed in heart, spleen, lung, and inner ear (PubMed:29255404). In the inner ear, expressed in the vestibule, basilar membrane and spiral ganglion cells (PubMed:29255404). Expressed in the supporting cells in both the organ of Corti and the vestibular sensory epithelia (PubMed:23023331). Expressed in the central nervous system and in muscle at 16 dpc and onward (PubMed:18611855). Expressed in the inner ear and retina at 15.5 and 17.5 dpc (PubMed:23023331). Detected in stereocilia of cochlear hair cells at P12 and as early as P5 (at protein level) (PubMed:28663585). At P12, expressed in stereocilia and at the tips of surrounding microvilli of the auditory hair cells (at protein level) (PubMed:28663585). At P12 in the inner hair cells, distributed along the length of stereocilia and accumulated at the tips of the shortest, but still mechanotransducing, stereocili (at protein level) (PubMed:28663585). At P12 in the outer hair cells (OHCs), punctate labeling along the length of stereocilia, including labeling at the very tips of OHC stereocilia (at protein level) (PubMed:28663585). Causes profound hearing loss, whereas balance and retinal functions appear normal (PubMed:29255404, PubMed:29084757). Impaired stereocilia development in hair cells (PubMed:29255404). Abolished mechanoelectrical transduction (MET) currents in auditory hair cells; while unchanged in vestibular hair cells (PubMed:29255404). Hair bundle morphological abnormalities begin after birth, with regression of the stereocilia and rapid hair-cell death (PubMed:29084757). At P6-P7, the rounded horseshoe-shape bundles at the base of the cochlea lack their typical V-shape (PubMed:29084757). At P7, disorganization of stereocilia in outer hair cells (OHC), with fragmentation in some stereocilia bundles and stereocilia in the shortest row are heterogeneous in length (PubMed:29255404, PubMed:29084757). The inner hair cell (IHC) hair bundles at the cochlear base exhibit an abnormal wavy shape, but, unlike OHCs, all the stereocilia within the same row are of the same length (PubMed:29084757). At P8, the second row of OHC stereocilia are over- grown to the height close to the first row, whereas the third row are largely retracted, resulting in the loss of their staircase architecture (PubMed:29255404). In IHC, the kinocilium is not retracted properly at P8 (PubMed:29255404). On P9, most OHCs have discontinuous horseshoe-like shaped hair bundles, due to the loss of the centrally located stereocilia at the vertex of the bundle (PubMed:29084757). Many IHC bundles at this terminal mature stage still retain their kinocilia, whereas the wild-type IHCs loose this structure at post-hearing onset (beyond P14) stages (PubMed:29084757). On P18, the short row stereocilia have almost entirely disappeared in both IHC and OHC hair bundles, whereas those in the middle row are much shorter than usual, with some missing entirely (PubMed:29084757). At P20, apoptotic hair cells in the cochlea are detected (PubMed:29084757). At P30, disorganization of stereocilia is increased, with complete loss of stereocilia in some animals and other morphological abnormalities, such as stereocilia fusion (PubMed:29255404). On P90 and P120, only sporadic fused stereocilia or residual knoblike protrusions are observed on some of the remaining IHC stereociliary bundles of the mid-basal cochlea (PubMed:29084757). Near-complete loss of IHC and OHC bundles on P120 (PubMed:29084757). The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo- CIB (calcium- and magnesium-free form). magnesium ion binding photoreceptor outer segment photoreceptor inner segment integrin binding calcium ion binding cytoplasm plasma membrane muscle tendon junction positive regulation of cytosolic calcium ion concentration membrane neuromuscular junction stereocilium cuticular plate sarcolemma protein homodimerization activity cell projection macromolecular complex binding photoreceptor cell maintenance metal ion binding calcium ion homeostasis cellular response to ATP uc009prf.1 uc009prf.2 uc009prf.3 
ENSMUST00000041905.8 Gm49336 ENSMUST00000041905.8 nucleoporin 58, transcript variant 1 (from RefSeq NM_170591.2) ENSMUST00000041905.1 ENSMUST00000041905.2 ENSMUST00000041905.3 ENSMUST00000041905.4 ENSMUST00000041905.5 ENSMUST00000041905.6 ENSMUST00000041905.7 NM_170591 NUP58_MOUSE Nup58 Nupl1 Q3UJF4 Q8BUA7 Q8BVG7 Q8C0W3 Q8R332 uc007uez.1 uc007uez.2 uc007uez.3 Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58. Interacts with NUTF2. Interacts with SRP1- alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone (By similarity). Q8R332-1; P63085: Mapk1; NbExp=3; IntAct=EBI-646962, EBI-397697; Nucleus, nuclear pore complex Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=p58; IsoId=Q8R332-1; Sequence=Displayed; Name=2; IsoId=Q8R332-2; Sequence=VSP_008573; Name=3; IsoId=Q8R332-3; Sequence=VSP_008574; Name=4; IsoId=Q8R332-4; Sequence=VSP_008575; Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. O-glycosylated. In rat, the p62 complex contains two different isoforms of NUP58. Isoform p45 has however not been isolated in mouse so far. Belongs to the NUP58 family. protein binding nucleus nuclear envelope nuclear pore nucleocytoplasmic transport nuclear localization sequence binding protein transport membrane structural constituent of nuclear pore nuclear membrane macromolecular complex regulation of protein import into nucleus mRNA transport protein homooligomerization protein heterotetramerization protein heterooligomerization protein heterotrimerization uc007uez.1 uc007uez.2 uc007uez.3 
ENSMUST00000041913.13 Entrep3 ENSMUST00000041913.13 endosomal transmembrane epsin interactor 3, transcript variant 1 (from RefSeq NM_001014995.2) ENSMUST00000041913.1 ENSMUST00000041913.10 ENSMUST00000041913.11 ENSMUST00000041913.12 ENSMUST00000041913.2 ENSMUST00000041913.3 ENSMUST00000041913.4 ENSMUST00000041913.5 ENSMUST00000041913.6 ENSMUST00000041913.7 ENSMUST00000041913.8 ENSMUST00000041913.9 EREP3_MOUSE Entrep3 Fam189b NM_001014995 Q5HZJ5 uc008pxy.1 uc008pxy.2 uc008pxy.3 May interact with WWOX. Membrane ; Multi-pass membrane protein Belongs to the ENTREP family. cellular_component biological_process membrane integral component of membrane WW domain binding uc008pxy.1 uc008pxy.2 uc008pxy.3 
ENSMUST00000041956.14 Spag9 ENSMUST00000041956.14 sperm associated antigen 9, transcript variant 1 (from RefSeq NM_027569.3) ENSMUST00000041956.1 ENSMUST00000041956.10 ENSMUST00000041956.11 ENSMUST00000041956.12 ENSMUST00000041956.13 ENSMUST00000041956.2 ENSMUST00000041956.3 ENSMUST00000041956.4 ENSMUST00000041956.5 ENSMUST00000041956.6 ENSMUST00000041956.7 ENSMUST00000041956.8 ENSMUST00000041956.9 JIP4_MOUSE Jip4 Jsap2 Kiaa0516 Mapk8ip4 NM_027569 Q3UH77 Q3UHF0 Q58A65 Q58VQ4 Q5NC70 Q5NC78 Q6A057 Q6PAS3 Q8CJC2 Spag9 uc007kxx.1 uc007kxx.2 uc007kxx.3 uc007kxx.4 The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12391307, PubMed:15767678). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (By similarity). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (PubMed:19056739). Homodimer (By similarity). The homodimer interacts with ARF6, forming a heterotetramer (By similarity). Homooligomer (By similarity). Interacts with MAX, MAPK8, MAPK14, MAP3K3, MYC, and MAP2K4 (PubMed:12391307). Interacts with KNS2 (PubMed:15987681). Interaction with KNS2 is important in the formation of ternary complex with MAPK8 (PubMed:15767678). Interacts with PIP4P1 (By similarity). Interacts with PIKFYVE (PubMed:19056739). Q58A65; P62331: Arf6; NbExp=10; IntAct=EBI-6530207, EBI-988682; Q58A65; Q5S007: LRRK2; Xeno; NbExp=2; IntAct=EBI-6530207, EBI-5323863; Cytoplasm toplasm, perinuclear region sosome membrane Note=Perinuclear distribution in response to stress signals such as UV radiation. Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=JLP(L) ; IsoId=Q58A65-1; Sequence=Displayed; Name=2; IsoId=Q58A65-2; Sequence=VSP_018228; Name=3; IsoId=Q58A65-3; Sequence=VSP_018226, VSP_018227, VSP_018228, VSP_018229; Name=4; IsoId=Q58A65-4; Sequence=VSP_018226, VSP_018227, VSP_018228, VSP_018230; Name=5; IsoId=Q58A65-5; Sequence=VSP_018227, VSP_018228; Name=6; IsoId=Q58A65-6; Sequence=VSP_018225, VSP_018228; [Isoform 6]: Highly expressed in brain, kidney, liver, heart. Up-regulated during neuronal differentiation. Phosphorylated by MAPK8 and MAPK14. Belongs to the JIP scaffold family. Sequence=BAD32239.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAI35376.1; Type=Erroneous gene model prediction; Evidence=; activation of MAPK activity MAP-kinase scaffold activity protein binding cytoplasm lysosome lysosomal membrane microtubule organizing center cytosol activation of JUN kinase activity JUN kinase binding membrane vesicle-mediated transport kinesin binding receptor signaling complex scaffold activity positive regulation of cell migration lysosome localization retrograde transport, endosome to Golgi identical protein binding positive regulation of MAPK cascade positive regulation of neuron differentiation mitogen-activated protein kinase p38 binding perinuclear region of cytoplasm striated muscle cell differentiation uc007kxx.1 uc007kxx.2 uc007kxx.3 uc007kxx.4 
ENSMUST00000041964.7 H2-M11 ENSMUST00000041964.7 histocompatibility 2, M region locus 11 (from RefSeq NM_177635.2) ENSMUST00000041964.1 ENSMUST00000041964.2 ENSMUST00000041964.3 ENSMUST00000041964.4 ENSMUST00000041964.5 ENSMUST00000041964.6 F6U8V3 F6U8V3_MOUSE H2-M11 NM_177635 uc289kvh.1 uc289kvh.2 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc289kvh.1 uc289kvh.2 
ENSMUST00000041965.5 Cdc42bpb ENSMUST00000041965.5 CDC42 binding protein kinase beta (from RefSeq NM_183016.2) Cdc42bpb E9QK15 ENSMUST00000041965.1 ENSMUST00000041965.2 ENSMUST00000041965.3 ENSMUST00000041965.4 Kiaa1124 MRCKB_MOUSE NM_183016 Q69ZR5 Q7TT50 Q80W33 uc007pct.1 uc007pct.2 uc007pct.3 uc007pct.4 Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A (By similarity). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (PubMed:25107909). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation. Inhibited by chelerythrine chloride (By similarity). Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42. Interacts with TJP1; this interaction requires the presence of catalytically active CDC42. Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPB and MYO18A. LURAP1 binding results in activation of CDC42BPB by abolition of its negative autoregulation. Interacts with STRIP1, STRN3 and SIKE1 (By similarity). Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Interacts with LURAP1 (By similarity). Interacts (via AGC-kinase C-terminal domain) with FAM89B/LRAP25 (via LRR repeat)(PubMed:25107909). Forms a tripartite complex with FAM89B/LRAP25 and LIMK1 (PubMed:25107909). Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell junction Cell projection, lamellipodium Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent. Detected at the leading edge of migrating and wounded cells; this localization requires the presence of catalytically active CDC42. Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner. Proteolytically cleaved by caspases upon apoptosis induction. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm cytoskeleton plasma membrane cell-cell junction protein phosphorylation membrane kinase activity phosphorylation cell migration transferase activity Rho GTPase binding peptidyl-threonine phosphorylation lamellipodium actin cytoskeleton organization cell junction actomyosin structure organization cell leading edge actin cytoskeleton reorganization intracellular signal transduction actomyosin cell projection macromolecular complex binding metal ion binding uc007pct.1 uc007pct.2 uc007pct.3 uc007pct.4 
ENSMUST00000041968.11 Tmem135 ENSMUST00000041968.11 transmembrane protein 135, transcript variant 1 (from RefSeq NM_028343.5) ENSMUST00000041968.1 ENSMUST00000041968.10 ENSMUST00000041968.2 ENSMUST00000041968.3 ENSMUST00000041968.4 ENSMUST00000041968.5 ENSMUST00000041968.6 ENSMUST00000041968.7 ENSMUST00000041968.8 ENSMUST00000041968.9 NM_028343 Q8BSY5 Q8CCZ6 Q8CE78 Q9CYV5 TM135_MOUSE Tmem135 uc009ifw.1 uc009ifw.2 uc009ifw.3 uc009ifw.4 Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission (PubMed:27863209). May act as a regulator of mitochondrial fission that promotes DNM1L- dependent fission through activation of DNM1L (PubMed:27863209). May be involved in peroxisome organization (By similarity). Mitochondrion membrane ; Multi-pass membrane protein Peroxisome membrane ; Multi-pass membrane protein Up-regulated following cold exposure and upon fasting. Age-dependent pathologies, characterized by accelerated aging in the retina similar to macular degeneration of the retina (PubMed:27863209). Retina show higher sensitivity to oxidative stress (PubMed:27863209). Defects are caused by impaired balance between mitochondrial fusion and fission (PubMed:27863209). Belongs to the TMEM135 family. molecular_function cytoplasm mitochondrion peroxisome peroxisomal membrane lipid particle peroxisome organization determination of adult lifespan response to cold positive regulation of gene expression positive regulation of lipid storage positive regulation of mitochondrial membrane potential membrane integral component of membrane mitochondrial membrane response to food regulation of mitochondrial fission uc009ifw.1 uc009ifw.2 uc009ifw.3 uc009ifw.4 
ENSMUST00000041973.7 Cmtm2b ENSMUST00000041973.7 CKLF-like MARVEL transmembrane domain containing 2B (from RefSeq NM_028524.3) CLF2B_MOUSE Cklfsf2b ENSMUST00000041973.1 ENSMUST00000041973.2 ENSMUST00000041973.3 ENSMUST00000041973.4 ENSMUST00000041973.5 ENSMUST00000041973.6 NM_028524 Q9DAC0 uc009nal.1 uc009nal.2 uc009nal.3 uc009nal.4 Membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=4; Name=4; IsoId=Q9DAC0-1; Sequence=Displayed; Name=1; Synonyms=1b; IsoId=Q9DAR1-1; Sequence=External; Name=2; IsoId=Q9DAR1-2; Sequence=External; Name=3; Synonyms=1a; IsoId=Q9DAR1-3; Sequence=External; Belongs to the chemokine-like factor family. cytokine activity extracellular space chemotaxis signal transduction membrane integral component of membrane uc009nal.1 uc009nal.2 uc009nal.3 uc009nal.4 
ENSMUST00000041982.9 H2-DMb2 ENSMUST00000041982.9 histocompatibility 2, class II, locus Mb2, transcript variant 1 (from RefSeq NM_010388.5) ENSMUST00000041982.1 ENSMUST00000041982.2 ENSMUST00000041982.3 ENSMUST00000041982.4 ENSMUST00000041982.5 ENSMUST00000041982.6 ENSMUST00000041982.7 ENSMUST00000041982.8 H2-DMb2 H2-M beta2 H2-Mb2 NM_010388 Q31099 Q31099_MOUSE Q31609 Q60975 uc008cbn.1 uc008cbn.2 uc008cbn.3 uc008cbn.4 Membrane ; Single- pass type I membrane protein Belongs to the MHC class II family. adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II protein binding lysosome lysosomal membrane late endosome multivesicular body immune response endosome membrane membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II MHC class II protein complex binding MHC class II protein complex chaperone mediated protein folding requiring cofactor uc008cbn.1 uc008cbn.2 uc008cbn.3 uc008cbn.4 
ENSMUST00000041984.14 Akap7 ENSMUST00000041984.14 A kinase anchor protein 7, transcript variant 1 (from RefSeq NM_018747.5) AKA7G_MOUSE Akap18 Akap7 ENSMUST00000041984.1 ENSMUST00000041984.10 ENSMUST00000041984.11 ENSMUST00000041984.12 ENSMUST00000041984.13 ENSMUST00000041984.2 ENSMUST00000041984.3 ENSMUST00000041984.4 ENSMUST00000041984.5 ENSMUST00000041984.6 ENSMUST00000041984.7 ENSMUST00000041984.8 ENSMUST00000041984.9 F8VQ58 NM_018747 Q7TN79 uc007eri.1 uc007eri.2 uc007eri.3 Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity). Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA (By similarity). Nucleus Cytoplasm Note=In oocytes, localizes to the nucleus, to germinal vesicles and throughout the cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=Gamma ; IsoId=Q7TN79-1; Sequence=Displayed; Name=Alpha ; IsoId=O55074-1; Sequence=External; Expressed in oocytes. nucleotide binding protein binding nucleus cytoplasm cytosol transmembrane receptor protein serine/threonine kinase signaling pathway protein C-terminus binding protein localization regulation of protein kinase A signaling membrane AMP binding apical plasma membrane lateral plasma membrane sarcoplasmic reticulum protein kinase binding protein domain specific binding T-tubule macromolecular complex protein kinase A regulatory subunit binding modulation of synaptic transmission protein kinase A binding regulation of membrane repolarization exocytic vesicle cellular response to cAMP positive regulation of potassium ion transmembrane transport positive regulation of delayed rectifier potassium channel activity uc007eri.1 uc007eri.2 uc007eri.3 
ENSMUST00000041987.8 Dicer1 ENSMUST00000041987.8 dicer 1, ribonuclease type III, transcript variant 1 (from RefSeq NM_001411829.1) Dicer1 ENSMUST00000041987.1 ENSMUST00000041987.2 ENSMUST00000041987.3 ENSMUST00000041987.4 ENSMUST00000041987.5 ENSMUST00000041987.6 ENSMUST00000041987.7 F8VQ54 F8VQ54_MOUSE NM_001411829 uc007oxi.1 uc007oxi.2 uc007oxi.3 Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.3; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Belongs to the helicase family. Dicer subfamily. DNA binding RNA binding double-stranded RNA binding endoribonuclease activity ribonuclease III activity ATP binding endoplasmic reticulum-Golgi intermediate compartment RNA processing negative regulation of gene expression rRNA catabolic process RISC complex hydrolase activity endoribonuclease activity, producing 5'-phosphomonoesters protein domain specific binding production of siRNA involved in RNA interference targeting of mRNA for destruction involved in RNA interference axon dendrite growth cone gene silencing by RNA pre-miRNA processing negative regulation of tumor necrosis factor production conversion of ds siRNA to ss siRNA involved in RNA interference siRNA loading onto RISC involved in RNA interference tube formation production of miRNAs involved in gene silencing by miRNA siRNA binding miRNA loading onto RISC involved in gene silencing by miRNA conversion of ds siRNA to ss siRNA NIK/NF-kappaB signaling extracellular exosome RISC-loading complex pre-miRNA binding RNA phosphodiester bond hydrolysis, endonucleolytic uc007oxi.1 uc007oxi.2 uc007oxi.3 
ENSMUST00000041993.3 Iapp ENSMUST00000041993.3 islet amyloid polypeptide (from RefSeq NM_010491.2) ENSMUST00000041993.1 ENSMUST00000041993.2 IAPP_MOUSE NM_010491 P12968 uc009epb.1 uc009epb.2 uc009epb.3 uc009epb.4 uc009epb.5 Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Interacts with IDE and INS. Secreted. The mature protein is largely unstructured in the absence of a cognate ligand, but contrary to the human protein, it does not easily form fibrillar aggregates. Belongs to the calcitonin family. hormone activity extracellular region extracellular space cytosol adenylate cyclase-activating G-protein coupled receptor signaling pathway negative regulation of cell proliferation positive regulation of gene expression positive regulation of protein kinase A signaling positive regulation of cell death inclusion body sensory perception of pain endocrine pancreas development protein destabilization positive regulation of peptidyl-serine phosphorylation eating behavior identical protein binding neuronal cell body negative regulation of cell differentiation negative regulation of bone resorption protein homooligomerization positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade amylin receptor signaling pathway positive regulation of calcium ion import across plasma membrane amyloid fibril formation uc009epb.1 uc009epb.2 uc009epb.3 uc009epb.4 uc009epb.5 
ENSMUST00000041998.4 4930591A17Rik ENSMUST00000041998.4 4930591A17Rik (from geneSymbol) AK019837 ENSMUST00000041998.1 ENSMUST00000041998.2 ENSMUST00000041998.3 uc029uje.1 uc029uje.2 uc029uje.3 uc029uje.4 uc029uje.5 uc029uje.1 uc029uje.2 uc029uje.3 uc029uje.4 uc029uje.5 
ENSMUST00000042012.7 Sf3b3 ENSMUST00000042012.7 splicing factor 3b, subunit 3 (from RefSeq NM_133953.2) ENSMUST00000042012.1 ENSMUST00000042012.2 ENSMUST00000042012.3 ENSMUST00000042012.4 ENSMUST00000042012.5 ENSMUST00000042012.6 Kiaa0017 NM_133953 Q3UGI3 Q6ZQL0 Q8BUD9 Q8K2J8 Q921M3 SF3B3_MOUSE uc009nlb.1 uc009nlb.2 uc009nlb.3 Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre- mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B3 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs. Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Part of the SF3B subcomplex of the 17S U2 SnRNP complex. SF3B associates with the splicing subcomplex SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Within the SF3B subcomplex, interacts directly with SF3B1 (via HEAT domain), SF3B5 and PHF5A. Identified in the spliceosome A complex; remains associated with the spliceosome throughout the splicing process. Component of the spliceosome B complex. Identified in the spliceosome C complex. Identified in the spliceosome E complex. Component of the minor (U12-type spliceosome) spliceosome. Within this complex, interacts with SCNM1. Associates with the STAGA transcription coactivator-HAT complex. Interacts with SUPT3H. Interacts with TAF3. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q921M3-1; Sequence=Displayed; Name=2; IsoId=Q921M3-2; Sequence=VSP_022980; The core of the protein consists of three beta-propeller domains. Belongs to the RSE1 family. mRNA splicing, via spliceosome nucleic acid binding nucleus spliceosomal complex U12-type spliceosomal complex nucleolus mRNA processing RNA splicing negative regulation of protein catabolic process macromolecular complex binding U2-type precatalytic spliceosome catalytic step 2 spliceosome uc009nlb.1 uc009nlb.2 uc009nlb.3 
ENSMUST00000042021.5 Tspyl5 ENSMUST00000042021.5 testis-specific protein, Y-encoded-like 5 (from RefSeq NM_001085421.1) ENSMUST00000042021.1 ENSMUST00000042021.2 ENSMUST00000042021.3 ENSMUST00000042021.4 Kiaa1750 NM_001085421 Q69ZB3 TSYL5_MOUSE uc007vld.1 uc007vld.2 uc007vld.3 Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7 (By similarity). Interacts with USP7. Belongs to the nucleosome assembly protein (NAP) family. Sequence=BAD32531.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component nucleus nucleosome assembly positive regulation of cell proliferation positive regulation of protein ubiquitination regulation of growth positive regulation of protein kinase B signaling cellular response to gamma radiation uc007vld.1 uc007vld.2 uc007vld.3 
ENSMUST00000042025.12 Antxr1 ENSMUST00000042025.12 anthrax toxin receptor 1 (from RefSeq NM_054041.2) ANTR1_MOUSE Atr ENSMUST00000042025.1 ENSMUST00000042025.10 ENSMUST00000042025.11 ENSMUST00000042025.2 ENSMUST00000042025.3 ENSMUST00000042025.4 ENSMUST00000042025.5 ENSMUST00000042025.6 ENSMUST00000042025.7 ENSMUST00000042025.8 ENSMUST00000042025.9 NM_054041 Q505H2 Q9CZ52 Tem8 uc009cte.1 uc009cte.2 uc009cte.3 Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton. Cell membrane ; Single-pass type I membrane protein Cell projection, lamellipodium membrane ; Single-pass type I membrane protein Cell projection, filopodium membrane ; Single-pass type I membrane protein Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZ52-1; Sequence=Displayed; Name=2; IsoId=Q9CZ52-2; Sequence=VSP_000450; Belongs to the ATR family. Sequence=BAB28591.1; Type=Erroneous initiation; Evidence=; blood vessel development transmembrane signaling receptor activity collagen binding plasma membrane external side of plasma membrane cell surface membrane integral component of membrane reproductive process lamellipodium membrane filopodium membrane actin cytoskeleton reorganization substrate adhesion-dependent cell spreading signaling receptor activity cell projection metal ion binding actin filament binding negative regulation of extracellular matrix assembly toxin transport positive regulation of metallopeptidase activity uc009cte.1 uc009cte.2 uc009cte.3 
ENSMUST00000042026.5 Pkd2l1 ENSMUST00000042026.5 polycystic kidney disease 2-like 1 (from RefSeq NM_181422.3) A2A259 ENSMUST00000042026.1 ENSMUST00000042026.2 ENSMUST00000042026.3 ENSMUST00000042026.4 NM_181422 PK2L1_MOUSE Q14B55 Q14B73 Q80ZH4 Trpp3 uc008hpm.1 uc008hpm.2 uc008hpm.3 Pore-forming subunit of a heteromeric, non-selective cation channel that is permeable to Ca(2+) (PubMed:16891422, PubMed:15548533, PubMed:19464260, PubMed:20538909, PubMed:21185261, PubMed:22420714, PubMed:25820328, PubMed:28904867, PubMed:29567962). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration (PubMed:24336288, PubMed:24336289). The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336288). Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells (PubMed:16891422, PubMed:16929298, PubMed:20406802, PubMed:21098668, PubMed:21625513). The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again (PubMed:18535624, PubMed:19464260, PubMed:20538909, PubMed:20406802, PubMed:22420714, PubMed:28904867, PubMed:29567962). May play a role in the perception of carbonation taste (PubMed:19833970). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (PubMed:28553944). The ion channel is gated following an off-response property by acid: gated open after the removal of acid stimulus, but not during acid application (PubMed:18535624, PubMed:19464260, PubMed:20406802, PubMed:22420714, PubMed:28904867, PubMed:29567962). Responses to acid stimulus are inhibited by capsaicin (PubMed:22420714). Homotetramer (PubMed:25820328, PubMed:29567962). Heterotetramer with either PKD1L1, PKD1L3 or PKD1; the heterotetrameric complex probably contains 3 PKD1L2 chains plus one chain from another family member (PubMed:16891422, PubMed:15548533, PubMed:25820328, PubMed:29567962). Interacts with PKD1L1, forming a ciliary calcium channel (PubMed:24336289). Interacts with PKD1L3, forming a cation channel that is activated by low extracellular pH (PubMed:16891422, PubMed:18535624, PubMed:19464260, PubMed:20538909, PubMed:20406802, PubMed:22420714, PubMed:25820328, PubMed:29567962). Interacts with PKD1 (PubMed:15548533). Interacts with RACK1; inhibits the channel activity possibly by impairing localization to the cell membrane (By similarity). A2A259; Q2EG98: Pkd1l3; NbExp=2; IntAct=EBI-15594711, EBI-15594779; A2A259; A2A259: Pkd2l1; NbExp=2; IntAct=EBI-15594711, EBI-15594711; Cell projection, cilium membrane ; Multi-pass membrane protein Cell membrane ulti-pass membrane protein Cytoplasmic vesicle Note=Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane. Detected in kidney, testis and brain, (PubMed:25820328). Expressed in all 4 taste areas in taste buds. Detected in the taste pore region of circumvallate papillae, foliate papillae, fungiform papillae and palate (PubMed:16891422, PubMed:16929298, PubMed:20538909, PubMed:21625513). Expressed in cells distinct from those mediating sweet, umami and bitter taste (at protein level) (PubMed:16891422). Expressed in type III taste cells (at protein level) (PubMed:18156604). Ubiquitous (PubMed:15548533). Detected in circumvallate, foliate, fungiform and palate taste buds, in cells distinct from those mediating sweet, umami and bitter taste (PubMed:16929298, PubMed:21625513). Detected in taste tissues and testis (PubMed:16891422). The EF-hand domain probably mediates calcium-binding. It is not required for channel activation. Interaction of the cytoplasmic N- and C-terminal domains is important for channel activity. Palmitoylation is important for expression at the cell membrane and for channel activity. Intestinal malrotation in 50% of animals, while other organs do not show major organ laterality defects. Intestinal malformations are associated with SHH pathway defects during early development (PubMed:24336288). Partial reduction of chorda tympani nerve response to sour stimuli, without affecting sweet, salty, bitter, and umami perception (PubMed:21625513). Belongs to the polycystin family. The active channel complex is an obligate tetramer (PubMed:29567962). In contrast, the isolated cytoplasmic C-terminal domain forms homotrimers in vitro (PubMed:25820328). Likewise, photobleaching experiments suggest formation of homotrimers in the membrane (By similarity). Pkd1l3 and Pkd2l1 have been defined as sour taste receptor in gustatory cells based on a number of indirect evidences: Pkd2l1 is expressed in a subset of taste receptor cells distinct from those responsible for sweet, bitter and unami taste and genetic elimination of cells expressing Pkd2l1 reduces gustatory nerve responses to sour taste stimuli (PubMed:16891422, PubMed:16929298). However, a number of experiments have recently shown that the sour taste receptor activity is probably indirect: mice lacking Pkd2l1 only show partial defects in sour taste perception (PubMed:21625513). Moreover, the PKD1L3-PKD2L1 heteromer, when expressed in cells does not respond to acid stimuli used to evoke proton currents in taste cells (PubMed:21098668). detection of chemical stimulus involved in sensory perception of sour taste calcium activated cation channel activity cation channel activity calcium channel activity sodium channel activity calcium ion binding protein binding endoplasmic reticulum plasma membrane integral component of plasma membrane cilium ion transport cation transport calcium ion transport smoothened signaling pathway cytoskeletal protein binding response to water calcium-activated potassium channel activity membrane integral component of membrane cytoplasmic vesicle cation channel complex calcium channel complex sodium ion transmembrane transport identical protein binding cell projection intracellular membrane-bounded organelle receptor complex detection of chemical stimulus involved in sensory perception of taste sensory perception of sour taste detection of mechanical stimulus protein tetramerization protein homotetramerization muscle alpha-actinin binding alpha-actinin binding ciliary membrane calcium ion transmembrane transport cellular response to pH cellular response to acidic pH potassium ion transmembrane transport non-motile cilium inorganic cation transmembrane transport cell surface cation transmembrane transporter activity sour taste receptor activity uc008hpm.1 uc008hpm.2 uc008hpm.3 
ENSMUST00000042035.16 Adgrb1 ENSMUST00000042035.16 adhesion G protein-coupled receptor B1, transcript variant 1 (from RefSeq NM_174991.3) AGRB1_MOUSE Adgrb1 Bai1 ENSMUST00000042035.1 ENSMUST00000042035.10 ENSMUST00000042035.11 ENSMUST00000042035.12 ENSMUST00000042035.13 ENSMUST00000042035.14 ENSMUST00000042035.15 ENSMUST00000042035.2 ENSMUST00000042035.3 ENSMUST00000042035.4 ENSMUST00000042035.5 ENSMUST00000042035.6 ENSMUST00000042035.7 ENSMUST00000042035.8 ENSMUST00000042035.9 NM_174991 Q3UH36 Q3UHD1 Q8CGM0 uc007wco.1 uc007wco.2 uc007wco.3 Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:17960134). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:21245295, PubMed:26838550, PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (By similarity). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (By similarity). Promotes myoblast fusion (PubMed:23615608). Activates the Rho pathway in a G-protein-dependent manner (By similarity). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (PubMed:25751059). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (By similarity). [Vasculostatin-120]: Inhibits angiogenesis in a CD36- dependent manner. [Vasculostatin-40]: Inhibits angiogenesis. Interacts with ELMO1 and DOCK1 (PubMed:17960134). When bound to ELMO1 and DOCK1, acts as a module to promote apoptotic cell engulfment (PubMed:17960134). Interacts with MDM2; the interaction results in inhibition of MDM2-mediated ubiquitination and degradation of DLG4/PSD95 (PubMed:25751059). Interacts with PARD3 and TIAM1; the interaction is required for correct dendritic localization of PARD3 and TIAM1 and for dendritic spine formation (By similarity). Interacts with MAGI1, MAGI3 and BAIAP2 (By similarity). Interacts with PHYHIP (PubMed:11245925). Interacts with DLG4 (via PDZ domain) (By similarity). Vasculostatin-120: Interacts with CD36 (By similarity). Vasculostatin-120: Interacts with ARRB2 (By similarity). Interacts with BAIAP3; this interaction is direct (By similarity). Q3UHD1; Q92556-1: ELMO1; Xeno; NbExp=9; IntAct=EBI-911280, EBI-15668002; Cell membrane ulti-pass membrane protein Cell projection, phagocytic cup Cell junction, focal adhesion Cell projection, dendritic spine Postsynaptic density [Vasculostatin-120]: Secreted [Vasculostatin-40]: Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UHD1-1; Sequence=Displayed; Name=2; IsoId=Q3UHD1-2; Sequence=Not described; In brain, widespread expression in all neuropil- rich zones including spinal cord gray matter, cerebellar molecular layer, cerebral cortex, thalamic nuclei and basal ganglia with no expression in white matter (at protein level) (PubMed:20888903). In the cerebellar molecular layer, highly expressed in interneuron processes whereas Purkinje cells and their dendrites show weaker expression (at protein level) (PubMed:20888903). In the olfactory bulb, highly expressed in glomeruli (at protein level) (PubMed:20888903). In the retina, highly concentrated in the outer and inner plexiform layers (at protein level) (PubMed:20888903). Expressed in brain (PubMed:11245925). Enriched in hippocampus and cortex (PubMed:23595754). Also detected in other tissues including bone marrow and spleen (PubMed:17960134). The TSP type-1 repeats in the extracellular domain mediate binding to phosphatidylserine (PubMed:17960134). They are also required for bacterial recognition and binding to bacterial outer membrane lipopolysaccharide (PubMed:21245295). Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120. Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 321 and 329 with cleavage likely to be between Ser-326 and Leu-327. Ubiquitinated. Viable and fertile with normal brain anatomy but mutants display severe deficits in hippocampus-dependent spatial learning and memory that are accompanied by enhanced long-term potentiation, impaired long-term depression, a thinning of the postsynaptic density at hippocampal synapses, reduced protein levels of Dlg4 and increased Dlg4 polyubiquitination (PubMed:25751059). Smaller myofibers than wild-type animals and impaired muscle regeneration after injury (PubMed:23615608). Impaired bacterial clearance following E.coli infection (PubMed:26838550). RNAi-mediated knockdown in embryos results in greatly reduced dendritic spine density and small but significant increases in spine length and decreases in spine diameter (PubMed:23595754). [Isoform 2]: Observed very weakly in the kidney, skeletal muscle, skin, stomach, thymus and brain from embryonic day 18. By neonatal day 1, the expression is targeted only to the brain. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. lipopolysaccharide binding phosphatidylserine binding phagocytic cup immune system process transmembrane signaling receptor activity G-protein coupled receptor activity protein binding extracellular region extracellular space plasma membrane integral component of plasma membrane focal adhesion phagocytosis phagocytosis, recognition phagocytosis, engulfment signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway nervous system development muscle organ development negative regulation of endothelial cell migration postsynaptic density membrane integral component of membrane negative regulation of angiogenesis cell junction PDZ domain binding dendrite negative regulation of protein ubiquitination negative regulation of protein catabolic process cell projection dendritic spine apoptotic cell clearance engulfment of apoptotic cell innate immune response synapse postsynaptic membrane regulation of synaptic plasticity perinuclear region of cytoplasm defense response to Gram-negative bacterium regulation of synapse assembly positive regulation of synapse assembly postsynaptic actin cytoskeleton organization glutamatergic synapse integral component of postsynaptic membrane positive regulation of myoblast fusion positive regulation of reactive oxygen species biosynthetic process uc007wco.1 uc007wco.2 uc007wco.3 
ENSMUST00000042042.9 Slc51a ENSMUST00000042042.9 solute carrier family 51, alpha subunit (from RefSeq NM_145932.3) ENSMUST00000042042.1 ENSMUST00000042042.2 ENSMUST00000042042.3 ENSMUST00000042042.4 ENSMUST00000042042.5 ENSMUST00000042042.6 ENSMUST00000042042.7 ENSMUST00000042042.8 NM_145932 OSTA_MOUSE Osta Q8R000 uc007yyx.1 uc007yyx.2 uc007yyx.3 Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:15563450, PubMed:16317684, PubMed:17650074, PubMed:18292224, PubMed:22535958). Efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684, PubMed:17650074, PubMed:18292224, PubMed:22535958). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine- conjugated bile acids (PubMed:16317684). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (By similarity). Able to transport eicosanoids such as prostaglandin E2 (By similarity). Reaction=taurocholate(out) = taurocholate(in); Xref=Rhea:RHEA:71703, ChEBI:CHEBI:36257; Evidence= Reaction=tauroursodeoxycholate(out) = tauroursodeoxycholate(in); Xref=Rhea:RHEA:71843, ChEBI:CHEBI:132028; Evidence=; Reaction=glycoursodeoxycholate(out) = glycoursodeoxycholate(in); Xref=Rhea:RHEA:71847, ChEBI:CHEBI:132030; Evidence=; Reaction=glycocholate(out) = glycocholate(in); Xref=Rhea:RHEA:71851, ChEBI:CHEBI:29746; Evidence=; Reaction=taurochenodeoxycholate(out) = taurochenodeoxycholate(in); Xref=Rhea:RHEA:71855, ChEBI:CHEBI:9407; Evidence=; Reaction=glycochenodeoxycholate(out) = glycochenodeoxycholate(in); Xref=Rhea:RHEA:71859, ChEBI:CHEBI:36252; Evidence=; Reaction=taurodeoxycholate(out) = taurodeoxycholate(in); Xref=Rhea:RHEA:71863, ChEBI:CHEBI:36261; Evidence=; Reaction=glycodeoxycholate(out) = glycodeoxycholate(in); Xref=Rhea:RHEA:71867, ChEBI:CHEBI:82982; Evidence=; Reaction=prostaglandin E2(out) = prostaglandin E2(in); Xref=Rhea:RHEA:50984, ChEBI:CHEBI:606564; Evidence=; Reaction=estrone 3-sulfate(out) = estrone 3-sulfate(in); Xref=Rhea:RHEA:71835, ChEBI:CHEBI:60050; Evidence=; Reaction=dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 3-sulfate(in); Xref=Rhea:RHEA:71839, ChEBI:CHEBI:57905; Evidence=; Interacts with SLC51B. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes. Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B. Present at high levels in ileum. In ileum, it is restricted to the apical domain on the mature villus enterocytes with little detectable expression in the goblet cells or crypt enterocytes (at protein level). Expressed in kidney but not in heart, brain, liver, spleen, embryo, lung, thymus, ovary nor testis. Positively regulated via the bile acid-activated nuclear receptor farnesoid X receptor (NR1H4/FXR). Up-regulated in mice lacking Mrp4, but it is unable to compensate for the absence of Mrp4. N-glycosylated. Mice are physically indistinguishable from wild- type mice but display strongly reduced transileal transport of taurocholate. Moreover, the bile acid pool size is significantly reduced, but fecal bile acid excretion is not elevated. Belongs to the OST-alpha family. protein binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane bile acid transmembrane transporter activity bile acid and bile salt transport membrane integral component of membrane basolateral plasma membrane transmembrane transporter activity bile acid secretion macromolecular complex protein homodimerization activity protein heterodimerization activity transmembrane transport organic substance transport uc007yyx.1 uc007yyx.2 uc007yyx.3 
ENSMUST00000042046.5 Scara3 ENSMUST00000042046.5 scavenger receptor class A, member 3 (from RefSeq NM_172604.3) ENSMUST00000042046.1 ENSMUST00000042046.2 ENSMUST00000042046.3 ENSMUST00000042046.4 NM_172604 Q8C6N1 Q8C850 SCAR3_MOUSE uc007ujr.1 uc007ujr.2 uc007ujr.3 Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Golgi apparatus membrane ; Single-pass type II membrane protein Note=Endoplasmic reticulum and/or Golgi. Golgi membrane extracellular matrix structural constituent collagen trimer collagen type IX trimer extracellular space endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus membrane integral component of membrane extracellular matrix organization extracellular matrix uc007ujr.1 uc007ujr.2 uc007ujr.3 
ENSMUST00000042052.9 Hectd1 ENSMUST00000042052.9 HECT domain E3 ubiquitin protein ligase 1, transcript variant 1 (from RefSeq NM_144788.3) ENSMUST00000042052.1 ENSMUST00000042052.2 ENSMUST00000042052.3 ENSMUST00000042052.4 ENSMUST00000042052.5 ENSMUST00000042052.6 ENSMUST00000042052.7 ENSMUST00000042052.8 F8WIE5 F8WIE5_MOUSE Hectd1 NM_144788 uc007nmz.1 uc007nmz.2 uc007nmz.3 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence= Protein modification; protein ubiquitination. Belongs to the UPL family. K-HECT subfamily. ubiquitin-protein transferase activity protein ubiquitination transferase activity metal ion binding uc007nmz.1 uc007nmz.2 uc007nmz.3 
ENSMUST00000042054.3 Foxf2 ENSMUST00000042054.3 forkhead box F2 (from RefSeq NM_010225.3) B2RQI5 ENSMUST00000042054.1 ENSMUST00000042054.2 FOXF2_MOUSE Lun NM_010225 O54743 Q3V1L3 Q78DW1 uc007pzo.1 uc007pzo.2 uc007pzo.3 uc007pzo.4 Probable transcription activator for a number of lung- specific genes (PubMed:9676429). Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (By similarity). Interacts with the transcription factors TBP and TFIIB. Nucleus Uniquely expressed in the bronchiolar epithelium and in type II pneumocytes. Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated transcription factor binding extracellular matrix organization regulation of proteasomal ubiquitin-dependent protein catabolic process establishment of planar polarity of embryonic epithelium sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic digestive tract development embryonic camera-type eye morphogenesis genitalia development palate development regulation of protein polyubiquitination uc007pzo.1 uc007pzo.2 uc007pzo.3 uc007pzo.4 
ENSMUST00000042055.10 Ptpa ENSMUST00000042055.10 protein phosphatase 2 protein activator, transcript variant 2 (from RefSeq NM_138748.5) ENSMUST00000042055.1 ENSMUST00000042055.2 ENSMUST00000042055.3 ENSMUST00000042055.4 ENSMUST00000042055.5 ENSMUST00000042055.6 ENSMUST00000042055.7 ENSMUST00000042055.8 ENSMUST00000042055.9 NM_138748 Ppp2r4 Ptpa Q543N6 Q543N6_MOUSE uc008jcn.1 uc008jcn.2 uc008jcn.3 uc008jcn.4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence= Cytoplasm Belongs to the PTPA-type PPIase family. protein phosphatase type 2A complex protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity receptor binding ATP binding nucleus nucleoplasm cytoplasm protein tyrosine phosphatase activator activity isomerase activity ATPase activity phosphatase activator activity protein phosphatase regulator activity negative regulation of phosphoprotein phosphatase activity positive regulation of phosphoprotein phosphatase activity calcium channel complex positive regulation of protein dephosphorylation negative regulation of protein dephosphorylation protein homodimerization activity positive regulation of apoptotic process regulation of phosphoprotein phosphatase activity protein phosphatase 2A binding uc008jcn.1 uc008jcn.2 uc008jcn.3 uc008jcn.4 
ENSMUST00000042057.12 Midn ENSMUST00000042057.12 midnolin, transcript variant 1 (from RefSeq NM_021565.2) ENSMUST00000042057.1 ENSMUST00000042057.10 ENSMUST00000042057.11 ENSMUST00000042057.2 ENSMUST00000042057.3 ENSMUST00000042057.4 ENSMUST00000042057.5 ENSMUST00000042057.6 ENSMUST00000042057.7 ENSMUST00000042057.8 ENSMUST00000042057.9 MIDN_MOUSE NM_021565 Q3TPJ7 Q3U3X5 Q9JJJ6 uc007gca.1 uc007gca.2 uc007gca.3 This gene encodes a protein that contains an ubiquitin-like domain. This protein may be involved in the regulation of brain development as inferred by its high expression level in the embryonic midbrain. This protein has been found to negatively regulate glucokinase activity and insulin secretion in pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (By similarity). Promotes also the degradation of other substrates such as CBX4 (PubMed:27326929). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (By similarity). Interacts with GCK; the interaction occurs preferentially at low glucose levels. Interacts with the proteasome. Nucleus toplasm, cytosol Nucleus, nucleolus Note=Detected in the nucleus and nucleolus with no expression in the cytoplasm (PubMed:10974535). However, a later study finds expression in the nucleus and cytoplasm with no expression in the nucleolus (PubMed:24187134). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TPJ7-1; Sequence=Displayed; Name=2; IsoId=Q3TPJ7-2; Sequence=VSP_025552; Name=3; IsoId=Q3TPJ7-3; Sequence=VSP_025552, VSP_025553; Expressed at high levels in brain and liver with significantly lower levels in muscle. Strongly expressed at the mesencephalon (midbrain) of 12.5 dpc embryos. nucleus nucleolus cytoplasm cytosol kinase binding negative regulation of glucokinase activity negative regulation of insulin secretion uc007gca.1 uc007gca.2 uc007gca.3 
ENSMUST00000042070.6 Zdhhc15 ENSMUST00000042070.6 zinc finger, DHHC domain containing 15 (from RefSeq NM_175358.4) ENSMUST00000042070.1 ENSMUST00000042070.2 ENSMUST00000042070.3 ENSMUST00000042070.4 ENSMUST00000042070.5 NM_175358 Q3TV63 Q8BGJ0 Q8BMB7 ZDH15_MOUSE Zdhhc15 uc009uaj.1 uc009uaj.2 uc009uaj.3 uc009uaj.4 Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:15603741, PubMed:17012030, PubMed:28167757). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable). Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (By similarity). Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (By similarity). In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis (PubMed:15603741). Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon (By similarity). Could also catalyze the palmitoylation of GAP43 (PubMed:15603741, PubMed:17012030). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (PubMed:18596047). Could also palmitoylate FYN as shown in vitro (By similarity). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Reaction=L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S- tetradecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59736, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:15433, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:143199; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59737; Evidence=; Reaction=L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S- octadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59740, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:15434, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:143200; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59741; Evidence=; Inhibited by 2-bromopalmitate. Golgi apparatus membrane ; Multi-pass membrane protein Postsynaptic density Expressed mainly in brain. The DHHC domain is required for palmitoyltransferase activity. Autopalmitoylated (in vitro). Belongs to the DHHC palmitoyltransferase family. Golgi membrane endoplasmic reticulum Golgi apparatus protein targeting to membrane membrane integral component of membrane synaptic vesicle maturation palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity establishment of protein localization metal ion binding uc009uaj.1 uc009uaj.2 uc009uaj.3 uc009uaj.4 
ENSMUST00000042078.10 Alx4 ENSMUST00000042078.10 aristaless-like homeobox 4 (from RefSeq NM_007442.3) ALX4_MOUSE ENSMUST00000042078.1 ENSMUST00000042078.2 ENSMUST00000042078.3 ENSMUST00000042078.4 ENSMUST00000042078.5 ENSMUST00000042078.6 ENSMUST00000042078.7 ENSMUST00000042078.8 ENSMUST00000042078.9 NM_007442 O35137 uc012bzt.1 uc012bzt.2 uc012bzt.3 Transcription factor involved in skull and limb development. Binds DNA. Nucleus. Expressed in osteoblasts. Not expressed in brain, heart, intestine, kidney, liver, muscle, spleen and testis. Expressed from 8.25 dpc and confined to mesenchymal cells throughout the embryo development. Expression is seen at several sites including craniofacial region, first branchial arch and anterior aspect of the limb bud. Note=Defects in Alx4 are the cause of Strong luxoid (lst) phenotype. At heterozygosity lst is characterized by preaxial abnormalities of the hindfeet and, very rarely, of the forefeet. Homozygotes show preaxial polydactyly of all four limbs, reductions and duplications of the radius, absence of the tibia, craniofacial defects, reduction of the pubis, and dorsal alopecia. Belongs to the paired homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding hair follicle development DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development pattern specification process muscle organ development post-embryonic development anterior/posterior pattern specification limb morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic digit morphogenesis regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity digestive tract development embryonic skeletal system morphogenesis skeletal system morphogenesis palate development HMG box domain binding uc012bzt.1 uc012bzt.2 uc012bzt.3 
ENSMUST00000042081.9 C3ar1 ENSMUST00000042081.9 complement component 3a receptor 1 (from RefSeq NM_009779.2) C3ar1 ENSMUST00000042081.1 ENSMUST00000042081.2 ENSMUST00000042081.3 ENSMUST00000042081.4 ENSMUST00000042081.5 ENSMUST00000042081.6 ENSMUST00000042081.7 ENSMUST00000042081.8 NM_009779 Q5U7A4 Q5U7A4_MOUSE uc009dps.1 uc009dps.2 uc009dps.3 Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. Interacts with VGF-derived peptide TLQP-21. Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. Belongs to the chemokine-like receptor (CMKLR) family. complement receptor mediated signaling pathway complement receptor activity complement component C3a receptor activity G-protein coupled receptor activity cell chemotaxis signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway uc009dps.1 uc009dps.2 uc009dps.3 
ENSMUST00000042090.8 Vmn2r107 ENSMUST00000042090.8 vomeronasal 2, receptor 107 (from RefSeq NM_001104569.1) E9PZJ7 E9PZJ7_MOUSE ENSMUST00000042090.1 ENSMUST00000042090.2 ENSMUST00000042090.3 ENSMUST00000042090.4 ENSMUST00000042090.5 ENSMUST00000042090.6 ENSMUST00000042090.7 NM_001104569 Vmn2r107 uc008apz.1 uc008apz.2 uc008apz.3 uc008apz.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc008apz.1 uc008apz.2 uc008apz.3 uc008apz.4 
ENSMUST00000042092.9 Cdh26 ENSMUST00000042092.9 cadherin-like 26, transcript variant 1 (from RefSeq NM_198656.3) CAD26_MOUSE ENSMUST00000042092.1 ENSMUST00000042092.2 ENSMUST00000042092.3 ENSMUST00000042092.4 ENSMUST00000042092.5 ENSMUST00000042092.6 ENSMUST00000042092.7 ENSMUST00000042092.8 Gm1010 NM_198656 P59862 uc008ohr.1 uc008ohr.2 uc008ohr.3 uc008ohr.4 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation. Homodimer. Component of a cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha- catenin/CTNNA1 and p120 catenin/CTNND1. Cell membrane ; Single-pass type I membrane protein Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. N-glycosylated. cell morphogenesis integrin binding calcium ion binding plasma membrane cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules beta-catenin binding cytoskeletal protein binding cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex adherens junction organization CD4-positive, alpha-beta T cell activation protein homodimerization activity cell-cell adhesion mediated by cadherin alpha-catenin binding cadherin binding metal ion binding delta-catenin binding cell-cell adhesion uc008ohr.1 uc008ohr.2 uc008ohr.3 uc008ohr.4 
ENSMUST00000042096.15 Emc1 ENSMUST00000042096.15 ER membrane protein complex subunit 1, transcript variant 2 (from RefSeq NM_001039200.2) B2RTJ5 EMC1_MOUSE ENSMUST00000042096.1 ENSMUST00000042096.10 ENSMUST00000042096.11 ENSMUST00000042096.12 ENSMUST00000042096.13 ENSMUST00000042096.14 ENSMUST00000042096.2 ENSMUST00000042096.3 ENSMUST00000042096.4 ENSMUST00000042096.5 ENSMUST00000042096.6 ENSMUST00000042096.7 ENSMUST00000042096.8 ENSMUST00000042096.9 Kiaa0090 NM_001039200 Q3TCG4 Q6ZQJ4 Q8C7X2 Q8K3W8 uc008vmh.1 uc008vmh.2 uc008vmh.3 uc008vmh.4 Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N- exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Component of the ER membrane protein complex (EMC). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C7X2-1; Sequence=Displayed; Name=2; IsoId=Q8C7X2-2; Sequence=VSP_020331; Name=3; IsoId=Q8C7X2-3; Sequence=VSP_020330; Belongs to the EMC1 family. molecular_function endoplasmic reticulum membrane integral component of membrane macromolecular complex ER membrane protein complex uc008vmh.1 uc008vmh.2 uc008vmh.3 uc008vmh.4 
ENSMUST00000042101.5 Agr3 ENSMUST00000042101.5 anterior gradient 3 (from RefSeq NM_207531.3) A7NSI1 AGR3_MOUSE Agr3 ENSMUST00000042101.1 ENSMUST00000042101.2 ENSMUST00000042101.3 ENSMUST00000042101.4 NM_207531 Q8BW95 Q8R3W7 uc007njl.1 uc007njl.2 uc007njl.3 uc007njl.4 Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells. Interacts with LYPD3 and DAG1 (alphaDAG1). Endoplasmic reticulum Cytoplasm Expressed in the ciliated cells of the airway epithelium. Not detected in the mucous cells. Knockout mice develop ciliated cells with normal- appearing cilia and histology. However, ciliary beat frequency was lower in airways from knockout mice compared with control mice in presence of calcium (20% lower in the absence of stimulation, 35% lower after ATP stimulation). Knockout mice show reduced mucociliary clearance. Knockout mice do not seem to show endoplasmic reticulum stress response. Belongs to the AGR family. dystroglycan binding cytoplasm endoplasmic reticulum intracellular membrane-bounded organelle negative regulation of cell death uc007njl.1 uc007njl.2 uc007njl.3 uc007njl.4 
ENSMUST00000042105.11 Ppp1r15a ENSMUST00000042105.11 protein phosphatase 1, regulatory subunit 15A (from RefSeq NM_008654.2) ENSMUST00000042105.1 ENSMUST00000042105.10 ENSMUST00000042105.2 ENSMUST00000042105.3 ENSMUST00000042105.4 ENSMUST00000042105.5 ENSMUST00000042105.6 ENSMUST00000042105.7 ENSMUST00000042105.8 ENSMUST00000042105.9 Gadd34 Myd116 NM_008654 P17564 PR15A_MOUSE Q3TJS6 Q3U3L5 Q8C579 uc009gvu.1 uc009gvu.2 uc009gvu.3 uc009gvu.4 Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress (PubMed:11381086, PubMed:12824288). Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1 (By similarity). May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15' (By similarity). Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (By similarity). Acts also a viral restriction factor by attenuating vesicular stomatitis virus (VSV) replication (PubMed:17670836). Interacts with PPP1CA (PubMed:9023344, PubMed:11381086). Interacts with EIF2S1 (By similarity). Interacts with PCNA (PubMed:9371605). Interacts with LYN and KMT2A/MLL1 (PubMed:11517336). Interacts with PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1. Interacts with NOX4 (By similarity). Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side Note=Associates with membranes via an N-terminal amphipathic intramembrane region. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P17564-1; Sequence=Displayed; Name=2; IsoId=P17564-2; Sequence=VSP_031651; Expressed strongly in spleen and lung, moderately in thymus and muscle, and weakly in brain. Expression starts at 8.5 dpc, and decreases to undetectable levels at 10.5 dpc and 11.5 dpc. Expression is strongly up-regulated at 12.5 dpc, decreases at 16.5 dpc and reappears at 18.5 dpc. At 12.5 dpc, ubiquitously expressed, with high levels in brain, spinal cord, tongue, lung and genital tubercle. Specifically produced in response to stress: in absence of stress, some upstream open reading frame (uORF) of this transcript is translated, thereby preventing its translation (PubMed:19131336). By IL6 and various endoplasmic stresses such as methyl methanesulfonate (PubMed:12606582, PubMed:12824288, PubMed:8139541). (Microbial infection) By infection with various viruses such as vesicular stomatitis virus (VSV). Phosphorylated at multiple Ser/Thr residues. Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity. Phosphorylation at Tyr-239 enhances proteasomal degradation, this position is dephosphorylated by PTPN2. Polyubiquitinated. Exhibits a rapid proteasomal degradation with a half-life under 1 hour, ubiquitination depends on endoplasmic reticulum association. Mice display abnormal erythrocytes and reduced hemoglobin content due to defects in hemoglobin synthesis. Belongs to the PPP1R15 family. protein phosphatase type 1 complex cytoplasm mitochondrion mitochondrial outer membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus regulation of translation apoptotic process protein phosphatase 1 binding positive regulation of gene expression membrane protein phosphatase regulator activity protein kinase binding protein phosphatase binding endoplasmic reticulum unfolded protein response negative regulation of phosphoprotein phosphatase activity positive regulation of phosphoprotein phosphatase activity positive regulation of peptidyl-serine phosphorylation response to endoplasmic reticulum stress negative regulation of protein dephosphorylation regulation of translational initiation by eIF2 alpha dephosphorylation positive regulation of transcription from RNA polymerase I promoter regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation peptidyl-serine dephosphorylation protein localization to endoplasmic reticulum positive regulation of peptidyl-serine dephosphorylation negative regulation of response to endoplasmic reticulum stress negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress uc009gvu.1 uc009gvu.2 uc009gvu.3 uc009gvu.4 
ENSMUST00000042118.11 Foxq1 ENSMUST00000042118.11 forkhead box Q1 (from RefSeq NM_008239.4) ENSMUST00000042118.1 ENSMUST00000042118.10 ENSMUST00000042118.2 ENSMUST00000042118.3 ENSMUST00000042118.4 ENSMUST00000042118.5 ENSMUST00000042118.6 ENSMUST00000042118.7 ENSMUST00000042118.8 ENSMUST00000042118.9 FOXQ1_MOUSE Hfh1 Hfh1l NM_008239 O70220 Q9JJ18 uc007pzj.1 uc007pzj.2 uc007pzj.3 uc007pzj.4 uc007pzj.5 Plays a role in hair follicle differentiation. Nucleus Expressed in kidney and stomach. Expression in the outer medulla of the kidney and the transitional epithelium. Expressed in the hair follicle medulla. Note=Defects in Foxq1 are the cause of the satin (sa) phenotype and results in a silky coat with high sheen arising from structurally abnormal medulla cells and defects in differentiation of the hair shaft. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter anatomical structure morphogenesis cell differentiation hair follicle morphogenesis negative regulation of neuron apoptotic process sequence-specific DNA binding uc007pzj.1 uc007pzj.2 uc007pzj.3 uc007pzj.4 uc007pzj.5 
ENSMUST00000042119.6 Slco1a1 ENSMUST00000042119.6 solute carrier organic anion transporter family, member 1a1 (from RefSeq NM_013797.5) ENSMUST00000042119.1 ENSMUST00000042119.2 ENSMUST00000042119.3 ENSMUST00000042119.4 ENSMUST00000042119.5 NM_013797 Oatp1a1 Q9QXZ6 SO1A1_MOUSE Slc21a1 Slco1a1 uc009eot.1 uc009eot.2 uc009eot.3 uc009eot.4 Mediates the Na(+)-independent transport of organic anions such as steroid sulfate conjugates (dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate), conjugated (taurocholate) and unconjugated (cholate) bile acids, prostaglandin E2 (PGE2) and L-thyroxine T4 (PubMed:10600646, PubMed:11267661). Also capable of transporting sulfobromophthalein (BSP), ouabain and gadoxetate (PubMed:10600646). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (By similarity). Reaction=estrone 3-sulfate(out) + hydrogencarbonate(in) = estrone 3- sulfate(in) + hydrogencarbonate(out); Xref=Rhea:RHEA:73055, ChEBI:CHEBI:17544, ChEBI:CHEBI:60050; Evidence=; Reaction=hydrogencarbonate(in) + taurocholate(out) = hydrogencarbonate(out) + taurocholate(in); Xref=Rhea:RHEA:73051, ChEBI:CHEBI:17544, ChEBI:CHEBI:36257; Evidence=; Reaction=L-thyroxine(out) = L-thyroxine(in); Xref=Rhea:RHEA:71819, ChEBI:CHEBI:58448; Evidence=; Reaction=prostaglandin E2(out) = prostaglandin E2(in); Xref=Rhea:RHEA:50984, ChEBI:CHEBI:606564; Evidence=; Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(out) = 17beta- estradiol 17-O-(beta-D-glucuronate)(in); Xref=Rhea:RHEA:72691, ChEBI:CHEBI:82961; Evidence=; Reaction=dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 3-sulfate(in); Xref=Rhea:RHEA:71839, ChEBI:CHEBI:57905; Evidence=; Kinetic parameters: KM=5 uM for estrone-3-sulfate (at pH 7.5) ; KM=12 uM for taurocholate (at pH 7.5) ; KM=8.2 uM for dehydroepiandrosterone sulfate (at pH 7.5) ; KM=4.9 uM for 17-beta-glucuronosyl estradiol (at pH 7.5) ; Binds to PDZK1. Interaction with PDZK1 is required for expression on hepatocyte surface (By similarity). Basolateral cell membrane ; Multi-pass membrane protein Highly expressed in liver, and at lower levels in kidney (PubMed:10600646, PubMed:11267661). Not detected in other tissues (PubMed:10600646). Belongs to the organo anion transporter (TC 2.A.60) family. plasma membrane integral component of plasma membrane ion transport organic anion transmembrane transporter activity bile acid transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity organic anion transport bile acid and bile salt transport membrane integral component of membrane basolateral plasma membrane response to testosterone response to stilbenoid sodium-independent organic anion transport transmembrane transport uc009eot.1 uc009eot.2 uc009eot.3 uc009eot.4 
ENSMUST00000042121.11 H2-DMa ENSMUST00000042121.11 histocompatibility 2, class II, locus DMa, transcript variant 2 (from RefSeq NM_010386.4) ENSMUST00000042121.1 ENSMUST00000042121.10 ENSMUST00000042121.2 ENSMUST00000042121.3 ENSMUST00000042121.4 ENSMUST00000042121.5 ENSMUST00000042121.6 ENSMUST00000042121.7 ENSMUST00000042121.8 ENSMUST00000042121.9 H2-DMa H2-M alpha H2-Ma MAq1 MAq2 MAq3 MAq4 MAq5 MAq6 MMMAq6 NM_010386 Q31621 Q31621_MOUSE Q9QWV0 uc289kbr.1 uc289kbr.2 uc289kbr.3 Membrane ; Single- pass type I membrane protein Belongs to the MHC class II family. adaptive immune response immune system process peptide antigen assembly with MHC class II protein complex antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune response cell surface membrane integral component of membrane antigen processing and presentation MHC class II protein complex binding MHC class II protein complex intracellular membrane-bounded organelle uc289kbr.1 uc289kbr.2 uc289kbr.3 
ENSMUST00000042125.15 Ttll4 ENSMUST00000042125.15 tubulin tyrosine ligase-like family, member 4 (from RefSeq NM_001014974.2) A4Q9E6 ENSMUST00000042125.1 ENSMUST00000042125.10 ENSMUST00000042125.11 ENSMUST00000042125.12 ENSMUST00000042125.13 ENSMUST00000042125.14 ENSMUST00000042125.2 ENSMUST00000042125.3 ENSMUST00000042125.4 ENSMUST00000042125.5 ENSMUST00000042125.6 ENSMUST00000042125.7 ENSMUST00000042125.8 ENSMUST00000042125.9 Kiaa0173 NM_001014974 Q5U4C4 Q80UG8 TTLL4_MOUSE Ttll4 uc007bmy.1 uc007bmy.2 uc007bmy.3 Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins (PubMed:17499049, PubMed:21074048, PubMed:20530212, PubMed:26829768). Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step (PubMed:17499049, PubMed:21074048). Preferentially modifies beta-tail tubulin over the alpha-tubulin (PubMed:17499049). Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4 (PubMed:17499049). Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function (PubMed:26829768). Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis (PubMed:29593216). Reaction=ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L- glutamyl-L-glutamyl-[protein] + H(+) + phosphate; Xref=Rhea:RHEA:60144, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15517, ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143622, ChEBI:CHEBI:456216; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60145; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Note=Located in cilia. In some cells, also found in basal bodies. Highly expressed in testis (PubMed:17499049). Expressed in brain, heart, kidney, liver, lung, muscle and spleen (PubMed:17499049). In the brain, expressed in ependymal cilia, the cortex and the striatum (PubMed:23897886). Expressed in blastomere (PubMed:29593216). The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding. Arg-722 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate- chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation. Knockout mice show hypoglutamylation of KLF4 resulting in KLF4 proteasome-mediated degradation in early-stage embryos and impaired early embryonic development. Belongs to the tubulin--tyrosine ligase family. nucleotide binding protein binding ATP binding cellular_component cytoplasm cytoskeleton microtubule cilium cellular protein modification process tubulin binding ligase activity protein polyglutamylation peptidyl-glutamic acid modification cell projection protein-glutamic acid ligase activity uc007bmy.1 uc007bmy.2 uc007bmy.3 
ENSMUST00000042135.14 Rasa4 ENSMUST00000042135.14 RAS p21 protein activator 4, transcript variant 3 (from RefSeq NR_189324.1) Capri ENSMUST00000042135.1 ENSMUST00000042135.10 ENSMUST00000042135.11 ENSMUST00000042135.12 ENSMUST00000042135.13 ENSMUST00000042135.2 ENSMUST00000042135.3 ENSMUST00000042135.4 ENSMUST00000042135.5 ENSMUST00000042135.6 ENSMUST00000042135.7 ENSMUST00000042135.8 ENSMUST00000042135.9 Kiaa0538 NR_189324 Q2PMI6 Q3U2R4 Q571H1 Q58DY7 Q6PFQ7 RASL2_MOUSE uc008zzt.1 uc008zzt.2 uc008zzt.3 uc008zzt.4 Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. Isoform 2 activates the Ras pathway and promotes RANKL shedding by modulating the expression of MMP14. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per C2 domain. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PFQ7-1; Sequence=Displayed; Name=2; Synonyms=deltaCAPRI; IsoId=Q6PFQ7-2; Sequence=VSP_032042; Isoform 2 is expressed in osteoblasts. The PH domain does not bind phosphatidylinositol 4,5- bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-591, compared to Arg found in other family members (By similarity). Sequence=BAD90143.1; Type=Erroneous initiation; Evidence=; GTPase activator activity phospholipid binding cytoplasm cytosol plasma membrane signal transduction membrane negative regulation of GTPase activity intracellular signal transduction regulation of GTPase activity positive regulation of GTPase activity negative regulation of Ras protein signal transduction metal ion binding cellular response to calcium ion uc008zzt.1 uc008zzt.2 uc008zzt.3 uc008zzt.4 
ENSMUST00000042147.6 Noc4l ENSMUST00000042147.6 NOC4 like (from RefSeq NM_153570.2) ENSMUST00000042147.1 ENSMUST00000042147.2 ENSMUST00000042147.3 ENSMUST00000042147.4 ENSMUST00000042147.5 NM_153570 NOC4L_MOUSE Q8BHY2 Q8R1F7 uc008yrd.1 uc008yrd.2 uc008yrd.3 Nucleus membrane ; Multi-pass membrane protein Nucleus, nucleolus Belongs to the CBF/MAK21 family. nucleus nucleolus membrane integral component of membrane Noc4p-Nop14p complex nuclear membrane small-subunit processome ribosome biogenesis uc008yrd.1 uc008yrd.2 uc008yrd.3 
ENSMUST00000042148.6 Mrps28 ENSMUST00000042148.6 mitochondrial ribosomal protein S28 (from RefSeq NM_025434.3) ENSMUST00000042148.1 ENSMUST00000042148.2 ENSMUST00000042148.3 ENSMUST00000042148.4 ENSMUST00000042148.5 NM_025434 Q8R2K6 Q9CY16 RT28_MOUSE uc008ooq.1 uc008ooq.2 uc008ooq.3 uc008ooq.4 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the bacterial ribosomal protein bS1 family. mitochondrion mitochondrial small ribosomal subunit ribosome biological_process uc008ooq.1 uc008ooq.2 uc008ooq.3 uc008ooq.4 
ENSMUST00000042158.13 Esyt3 ENSMUST00000042158.13 extended synaptotagmin-like protein 3 (from RefSeq NM_177775.3) D9Ertd280e ENSMUST00000042158.1 ENSMUST00000042158.10 ENSMUST00000042158.11 ENSMUST00000042158.12 ENSMUST00000042158.2 ENSMUST00000042158.3 ENSMUST00000042158.4 ENSMUST00000042158.5 ENSMUST00000042158.6 ENSMUST00000042158.7 ENSMUST00000042158.8 ENSMUST00000042158.9 ESYT3_MOUSE Fam62c Kiaa4186 NM_177775 Q0VF61 Q5DTI8 Q8C3B9 uc009reb.1 uc009reb.2 uc009reb.3 Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Cell membrane ; Peripheral membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Recruited to the cell membrane via the third C2 domain (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5DTI8-1; Sequence=Displayed; Name=2; IsoId=Q5DTI8-2; Sequence=VSP_030426; The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior (By similarity). Belongs to the extended synaptotagmin family. Sequence=BAC39655.1; Type=Frameshift; Evidence=; Sequence=BAD90311.1; Type=Erroneous initiation; Evidence=; calcium ion binding calcium-dependent phospholipid binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane lipid transport biological_process lipid binding phosphatidylethanolamine binding membrane integral component of membrane phosphatidylcholine binding intrinsic component of endoplasmic reticulum membrane extrinsic component of cytoplasmic side of plasma membrane phosphatidylinositol binding organelle membrane contact site metal ion binding endoplasmic reticulum-plasma membrane tethering uc009reb.1 uc009reb.2 uc009reb.3 
ENSMUST00000042163.15 Naa25 ENSMUST00000042163.15 N(alpha)-acetyltransferase 25, NatB auxiliary subunit (from RefSeq NM_172722.4) A1A4B7 ENSMUST00000042163.1 ENSMUST00000042163.10 ENSMUST00000042163.11 ENSMUST00000042163.12 ENSMUST00000042163.13 ENSMUST00000042163.14 ENSMUST00000042163.2 ENSMUST00000042163.3 ENSMUST00000042163.4 ENSMUST00000042163.5 ENSMUST00000042163.6 ENSMUST00000042163.7 ENSMUST00000042163.8 ENSMUST00000042163.9 Mdm20 NAA25_MOUSE NM_172722 Q3KQI7 Q3TJC6 Q7TMM2 Q8BWZ3 uc008zjc.1 uc008zjc.2 uc008zjc.3 Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. May play a role in normal cell-cycle progression. Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BWZ3-1; Sequence=Displayed; Name=2; IsoId=Q8BWZ3-2; Sequence=VSP_026631; Belongs to the MDM20/NAA25 family. cytoplasm Golgi apparatus cytosol N-terminal peptidyl-methionine acetylation NatB complex peptide alpha-N-acetyltransferase activity uc008zjc.1 uc008zjc.2 uc008zjc.3 
ENSMUST00000042166.11 Ramac ENSMUST00000042166.11 RNA guanine-7 methyltransferase activating subunit (from RefSeq NM_025997.2) ENSMUST00000042166.1 ENSMUST00000042166.10 ENSMUST00000042166.2 ENSMUST00000042166.3 ENSMUST00000042166.4 ENSMUST00000042166.5 ENSMUST00000042166.6 ENSMUST00000042166.7 ENSMUST00000042166.8 ENSMUST00000042166.9 Fam103a1 NM_025997 Q3TV69 Q9CQY2 Q9CWI1 RAMAC_MOUSE Rammet uc009icl.1 uc009icl.2 uc009icl.3 Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT. Regulates RNMT expression by a post-transcriptional stabilizing mechanism. Binds RNA. Interacts with RNMT; this interaction enhances mRNA binding and cap methyltransferase activity. Nucleus Belongs to the RAM family. RNA binding nucleus nucleoplasm mRNA cap binding complex 7-methylguanosine mRNA capping mRNA processing mRNA cap methyltransferase complex methylation recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex mRNA (guanine-N7-)-methyltransferase activity uc009icl.1 uc009icl.2 uc009icl.3 
ENSMUST00000042167.10 Cpq ENSMUST00000042167.10 carboxypeptidase Q, transcript variant 2 (from RefSeq NM_176073.4) CBPQ_MOUSE ENSMUST00000042167.1 ENSMUST00000042167.2 ENSMUST00000042167.3 ENSMUST00000042167.4 ENSMUST00000042167.5 ENSMUST00000042167.6 ENSMUST00000042167.7 ENSMUST00000042167.8 ENSMUST00000042167.9 Hls2 NM_176073 O70216 Pgcp Q3U8N9 Q9WVJ3 uc007vlb.1 uc007vlb.2 Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor (By similarity). Homodimer. The monomeric form is inactive while the homodimer is active (By similarity). Endoplasmic reticulum Golgi apparatus Lysosome Secreted Note=Secretion is stimulated by TSH/thyroid-stimulating hormone, INS/insulin and SST/somatostatin. N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide chains. Belongs to the peptidase M28 family. Sequence=AAC17945.1; Type=Frameshift; Evidence=; Sequence=AAC17945.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; carboxypeptidase activity extracellular region extracellular space cytoplasm lysosome endoplasmic reticulum Golgi apparatus proteolysis thyroid hormone generation peptidase activity metallopeptidase activity hydrolase activity tissue regeneration protein homodimerization activity peptide catabolic process intracellular membrane-bounded organelle metal ion binding metallodipeptidase activity uc007vlb.1 uc007vlb.2 
ENSMUST00000042172.7 Tmem247 ENSMUST00000042172.7 transmembrane protein 247, transcript variant 1 (from RefSeq NM_030104.1) ENSMUST00000042172.1 ENSMUST00000042172.2 ENSMUST00000042172.3 ENSMUST00000042172.4 ENSMUST00000042172.5 ENSMUST00000042172.6 NM_030104 Q497K7 Q8BVQ7 Q9CU05 TM247_MOUSE uc008duk.1 uc008duk.2 uc008duk.3 uc008duk.4 uc008duk.5 Membrane ; Multi-pass membrane protein Sequence=AAI00487.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function endoplasmic reticulum biological_process membrane integral component of membrane uc008duk.1 uc008duk.2 uc008duk.3 uc008duk.4 uc008duk.5 
ENSMUST00000042194.10 Trpm4 ENSMUST00000042194.10 transient receptor potential cation channel, subfamily M, member 4 (from RefSeq NM_175130.4) ENSMUST00000042194.1 ENSMUST00000042194.2 ENSMUST00000042194.3 ENSMUST00000042194.4 ENSMUST00000042194.5 ENSMUST00000042194.6 ENSMUST00000042194.7 ENSMUST00000042194.8 ENSMUST00000042194.9 Ltrpc4 NM_175130 Q6PDM0 Q769E2 Q769E4 Q7TN37 Q80Y94 Q80YB3 Q811E2 TRPM4_MOUSE uc009gup.1 uc009gup.2 uc009gup.3 uc009gup.4 Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:17188667, PubMed:29211714). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway (By similarity). Essential for the migration but not the maturation of dendritic cells (PubMed:18758465). Plays a role in keratinocyte differentiation (By similarity). Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca(2+) sensitivity. ATP is able to restore Ca(2+) sensitivity after desensitization. Phosphatidylinositol 4,5-bisphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca(2+) sensitivity and shifting its voltage dependence of activation towards negative potentials. Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2) (By similarity). Inhibited by flufenamic acid and glibenclamide (PubMed:17188667). Homotetramer. Cell membrane ulti-pass membrane protein Endoplasmic reticulum Golgi apparatus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7TN37-1; Sequence=Displayed; Name=2; Synonyms=A; IsoId=Q7TN37-2; Sequence=VSP_021444; Name=3; Synonyms=B; IsoId=Q7TN37-3; Sequence=VSP_021444, VSP_021445; Sino-atrial nodes (at protein level). Widely expressed. Phosphorylation by PKC leads to increase the sensitivity to Ca(2+). Sumoylated. Desumoylated by SENP1. Mice have fewer dendritic cells in lymphoid organs and impaired migration of dendritic cells is seen. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily. nucleotide binding adaptive immune response immune system process dendritic cell chemotaxis regulation of T cell cytokine production ion channel activity calcium activated cation channel activity voltage-gated ion channel activity calcium channel activity calcium ion binding calmodulin binding ATP binding nucleoplasm endoplasmic reticulum Golgi apparatus cytosol plasma membrane ion transport cation transport calcium ion transport positive regulation of cytosolic calcium ion concentration positive regulation of cell proliferation positive regulation of heart rate membrane integral component of membrane protein sumoylation calcium-mediated signaling negative regulation of bone mineralization ion transmembrane transport sodium channel complex positive regulation of insulin secretion involved in cellular response to glucose stimulus vasoconstriction regulation of membrane potential neuronal cell body spanning component of plasma membrane positive regulation of fat cell differentiation negative regulation of osteoblast differentiation positive regulation of vasoconstriction metal ion binding protein homotetramerization transmembrane transport cardiac conduction calcium ion transmembrane transport cellular response to ATP membrane depolarization during AV node cell action potential membrane depolarization during Purkinje myocyte cell action potential membrane depolarization during bundle of His cell action potential regulation of heart rate by cardiac conduction spanning component of membrane positive regulation of canonical Wnt signaling pathway inorganic cation transmembrane transport sodium ion import across plasma membrane regulation of ventricular cardiac muscle cell action potential positive regulation of atrial cardiac muscle cell action potential positive regulation of adipose tissue development positive regulation of regulation of vascular smooth muscle cell membrane depolarization uc009gup.1 uc009gup.2 uc009gup.3 uc009gup.4 
ENSMUST00000042196.4 Vwa1 ENSMUST00000042196.4 von Willebrand factor A domain containing 1 (from RefSeq NM_147776.4) ENSMUST00000042196.1 ENSMUST00000042196.2 ENSMUST00000042196.3 NM_147776 Q8C0Q7 Q8R2Z5 Q8VDV9 Q923K3 VWA1_MOUSE Warp uc008weq.1 uc008weq.2 uc008weq.3 uc008weq.4 Promotes matrix assembly (PubMed:18757743). Involved in the organization of skeletal muscles and in the formation of neuromuscular junctions (By similarity). Homodimer or homomultimer; disulfide-linked. Interacts with HSPG2. Secreted, extracellular space, extracellular matrix, basement membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R2Z5-1; Sequence=Displayed; Name=2; IsoId=Q8R2Z5-2; Sequence=VSP_028618; Expressed at high levels in the chondrocytes. Detected in the vasculature of neural tissues, in basement membrane structures of the peripheral nervous system, in the apical ectodermal ridge of developing limb buds, and in skeletal and cardiac muscle (at protein level). Restricted to the presumptive articular cartilage zone prior to joint cavitation and to the articular cartilage and fibrocartilaginous elements in the joint, spine and sternum during embryonic development. Detected from 9.5 dpc in the vasculature of the central nervous system. At 16.5 dpc, present in intervertebral disks of the spinal cord, lip epithelium and developing oral and tooth germ epithelia (at protein level). N-glycosylated. growth plate cartilage chondrocyte morphogenesis extracellular matrix structural constituent protein binding extracellular region basement membrane interstitial matrix extracellular space extracellular matrix organization extracellular matrix identical protein binding behavioral response to pain uc008weq.1 uc008weq.2 uc008weq.3 uc008weq.4 
ENSMUST00000042203.10 Wdr5b ENSMUST00000042203.10 WD repeat domain 5B (from RefSeq NM_027113.2) ENSMUST00000042203.1 ENSMUST00000042203.2 ENSMUST00000042203.3 ENSMUST00000042203.4 ENSMUST00000042203.5 ENSMUST00000042203.6 ENSMUST00000042203.7 ENSMUST00000042203.8 ENSMUST00000042203.9 NM_027113 Q9D7H2 WDR5B_MOUSE uc007zcc.1 uc007zcc.2 uc007zcc.3 May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex. Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1. Belongs to the WD repeat WDR5/wds family. nucleus histone binding Set1C/COMPASS complex histone H3-K4 methylation uc007zcc.1 uc007zcc.2 uc007zcc.3 
ENSMUST00000042217.4 Rspo4 ENSMUST00000042217.4 R-spondin 4 (from RefSeq NM_001040689.1) ENSMUST00000042217.1 ENSMUST00000042217.2 ENSMUST00000042217.3 NM_001040689 Q8BJ73 RSPO4_MOUSE uc008nep.1 uc008nep.2 Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Binds heparin (By similarity). Interacts with LGR4, LGR5 and LGR6. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BJ73-1; Sequence=Displayed; Name=2; IsoId=Q8BJ73-2; Sequence=VSP_018326, VSP_018327; The FU repeat is required for activation and stabilization of beta-catenin. Belongs to the R-spondin family. Sequence=BAC25643.1; Type=Frameshift; Evidence=; extracellular region heparin binding Wnt signaling pathway positive regulation of Wnt signaling pathway nail development response to stimulus uc008nep.1 uc008nep.2 
ENSMUST00000042219.6 Calm4 ENSMUST00000042219.6 calmodulin 4 (from RefSeq NM_020036.4) CALM4_MOUSE Dd112 ENSMUST00000042219.1 ENSMUST00000042219.2 ENSMUST00000042219.3 ENSMUST00000042219.4 ENSMUST00000042219.5 NM_020036 Q9CR31 Q9D1E9 Q9JM83 uc007pjb.1 uc007pjb.2 uc007pjb.3 Implicated in the early stage of ectopic ossification. calcium ion binding calcium-mediated signaling metal ion binding cellular response to leukemia inhibitory factor uc007pjb.1 uc007pjb.2 uc007pjb.3 
ENSMUST00000042221.14 Slc26a7 ENSMUST00000042221.14 solute carrier family 26, member 7 (from RefSeq NM_145947.2) A2AJZ4 B1AWS0 ENSMUST00000042221.1 ENSMUST00000042221.10 ENSMUST00000042221.11 ENSMUST00000042221.12 ENSMUST00000042221.13 ENSMUST00000042221.2 ENSMUST00000042221.3 ENSMUST00000042221.4 ENSMUST00000042221.5 ENSMUST00000042221.6 ENSMUST00000042221.7 ENSMUST00000042221.8 ENSMUST00000042221.9 NM_145947 Q8R2Z3 S26A7_MOUSE Slc26a7 uc008saz.1 uc008saz.2 uc008saz.3 uc008saz.4 Acts as an anion channel mediating the transport of chloride, bromide, iodide, nitrate, sulfate, gluconate, thiocyanate and bicarbonate ions (PubMed:15591059, PubMed:24810589, PubMed:30333321, PubMed:32726161, PubMed:35788623). Its permeability towards bicarbonate is weak and increases when pH is above 7 (PubMed:15591059). Mediates oxalate transport (By similarity). Mediates thiocyanate transport in retinal pigment epithelium cells (PubMed:32726161). Mediates iodide transport in the thyroid gland, playing an important role in the synthesis of thyroid hormones and the maintenance of thyroid function (PubMed:30333321, PubMed:35788623). Although it is an anion channel, according to PubMed:12736153 and PubMed:19723628 it has been shown to exhibit chloride-bicarbonate exchanger activity. Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence= Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324, ChEBI:CHEBI:16382; Evidence= PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:66326; Evidence=; Reaction=bromide(in) = bromide(out); Xref=Rhea:RHEA:75383, ChEBI:CHEBI:15858; Evidence=; Reaction=oxalate(in) = oxalate(out); Xref=Rhea:RHEA:76199, ChEBI:CHEBI:30623; Evidence=; Reaction=nitrate(in) = nitrate(out); Xref=Rhea:RHEA:34923, ChEBI:CHEBI:17632; Evidence= Reaction=sulfate(in) = sulfate(out); Xref=Rhea:RHEA:34983, ChEBI:CHEBI:16189; Evidence=; Reaction=hydrogencarbonate(in) = hydrogencarbonate(out); Xref=Rhea:RHEA:28695, ChEBI:CHEBI:17544; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28697; Evidence=; Reaction=D-gluconate(in) = D-gluconate(out); Xref=Rhea:RHEA:76139, ChEBI:CHEBI:18391; Evidence=; Reaction=thiocyanate(in) = thiocyanate(out); Xref=Rhea:RHEA:75347, ChEBI:CHEBI:18022; Evidence=; Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) + hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996; Evidence= Regulated by pH. Activity inhibited by all inhibitors of several anion channels and transporters, including 4,4'- Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS), diphenylamine-2- carboxylic acid, glybenclamide and 5-Nitro-2-(3-phenylpropyl- amino)benzoic acid. Basolateral cell membrane ulti-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Lateral cell membrane ; Multi-pass membrane protein Note=Expressed on the basolateral membrane of acid- secreting gastric parietal cells, distal nephron segments and apical domains of proximal tubules and in the glomerulus. Expressed in the cytoplasm in recycling endosomes of kidney outer medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. Expressed in the Reissner's membrane epithelial cells in the cochlea (at protein level) (PubMed:24810589). Expressed in the retinal pigment epithelium (at protein level) (PubMed:32726161). Abundantly expressed in parietal cells on the glandular portion of the stomach. Lower levels are observed in the kidney, with expression in the proximal tubule and thick ascending limb of the loop of Henle. Also expressed in distal segments of nephron, in extraglomerular mesagial cells and a subpopulation of intercalated cells of outer medullary collecting ducts. Expressed in the thyroid gland. Mice develop goitrous congenital hypothyroidism, with enlarged thyroid gland and severely reduced T4 than T3 in the serum and thyroid gland (PubMed:30333321, PubMed:35788623). Animals fed a low iodine diet show more severe growth failure than those fed a normal diet (PubMed:35788623). Develop distal renal tubular acidosis, manifested by metabolic acidosis and alkaline urine pH and in the stomach, stimulated acid secretion is significantly impaired (PubMed:19723628). Retinal pigment epithelium cells (RPE) from Slc26a7 KO mice have a dramatically smaller whole cell SCN (-) conductance compared with wild-type RPE cells (PubMed:32726161). Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Although it is an anion channel, according to PubMed:12736153 and PubMed:19723628 it has been shown to exhibit chloride-bicarbonate exchanger activity. gastric acid secretion anion channel activity chloride channel activity cytoplasm endosome plasma membrane integral component of plasma membrane ion transport anion transport chloride transport secondary active sulfate transmembrane transporter activity sulfate transport anion transmembrane transporter activity bicarbonate transmembrane transporter activity chloride transmembrane transporter activity sulfate transmembrane transporter activity anion:anion antiporter activity bicarbonate transport membrane integral component of membrane basolateral plasma membrane oxalate transmembrane transporter activity oxalate transport recycling endosome membrane transmembrane transport anion transmembrane transport sulfate transmembrane transport chloride transmembrane transport uc008saz.1 uc008saz.2 uc008saz.3 uc008saz.4 
ENSMUST00000042227.15 Mtnap1 ENSMUST00000042227.15 mitochondrial nucleoid associated protein 1, transcript variant 1 (from RefSeq NM_177777.6) CQ080_MOUSE D11Wsu47e ENSMUST00000042227.1 ENSMUST00000042227.10 ENSMUST00000042227.11 ENSMUST00000042227.12 ENSMUST00000042227.13 ENSMUST00000042227.14 ENSMUST00000042227.2 ENSMUST00000042227.3 ENSMUST00000042227.4 ENSMUST00000042227.5 ENSMUST00000042227.6 ENSMUST00000042227.7 ENSMUST00000042227.8 ENSMUST00000042227.9 NM_177777 Q3UTJ1 Q6PIX9 Q80UV5 Q9CYN0 uc007mex.1 uc007mex.2 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PIX9-1; Sequence=Displayed; Name=2; IsoId=Q6PIX9-2; Sequence=VSP_024575; Sequence=BAB30780.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; molecular_function biological_process membrane integral component of membrane uc007mex.1 uc007mex.2 
ENSMUST00000042235.15 Eef1a1 ENSMUST00000042235.15 eukaryotic translation elongation factor 1 alpha 1 (from RefSeq NM_010106.2) ENSMUST00000042235.1 ENSMUST00000042235.10 ENSMUST00000042235.11 ENSMUST00000042235.12 ENSMUST00000042235.13 ENSMUST00000042235.14 ENSMUST00000042235.2 ENSMUST00000042235.3 ENSMUST00000042235.4 ENSMUST00000042235.5 ENSMUST00000042235.6 ENSMUST00000042235.7 ENSMUST00000042235.8 ENSMUST00000042235.9 Eef1a1 NM_010106 Q58E64 Q58E64_MOUSE uc009qun.1 uc009qun.2 uc009qun.3 uc009qun.4 This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. tRNA binding nucleotide binding mRNA binding translation elongation factor activity GTPase activity GTP binding nucleus nucleolus cytoplasm cytosol plasma membrane translational elongation aging drug binding positive regulation of cell death positive regulation of neuron projection development kinase binding protein kinase binding cortical actin cytoskeleton ruffle membrane cellular response to drug protein homooligomerization cellular response to epidermal growth factor stimulus regulation of D-erythro-sphingosine kinase activity negative regulation of reactive oxygen species biosynthetic process cellular response to nerve growth factor stimulus uc009qun.1 uc009qun.2 uc009qun.3 uc009qun.4 
ENSMUST00000042246.14 Shc4 ENSMUST00000042246.14 SHC (Src homology 2 domain containing) family, member 4 (from RefSeq NM_199022.3) ENSMUST00000042246.1 ENSMUST00000042246.10 ENSMUST00000042246.11 ENSMUST00000042246.12 ENSMUST00000042246.13 ENSMUST00000042246.2 ENSMUST00000042246.3 ENSMUST00000042246.4 ENSMUST00000042246.5 ENSMUST00000042246.6 ENSMUST00000042246.7 ENSMUST00000042246.8 ENSMUST00000042246.9 NM_199022 Q6S5L9 SHC4_MOUSE Shcd uc008mcv.1 uc008mcv.2 uc008mcv.3 Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. Interacts (via PID domain) with phosphorylated MUSK (via NPXY motif); undergoes tyrosine phosphorylation downstream of activated MUSK. Interacts with GRB2; the interaction is dependent of Tyr-422 phosphorylation and increased by EGF (By similarity). Postsynaptic cell membrane Note=Colocalized with MUSK at the neuromuscular junction. Expressed in both brain and skeletal muscle; widely expressed in brain namely olfactory bulb, cortex, hippocampus, striatum, thalamus, and brain stem (at protein level). Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential. Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-422 is required for the interaction with GRB2 (By similarity). plasma membrane apoptotic process positive regulation of cell proliferation regulation of gene expression membrane protein kinase binding protein domain specific binding cell junction receptor tyrosine kinase binding intracellular signal transduction synapse postsynaptic membrane stem cell differentiation uc008mcv.1 uc008mcv.2 uc008mcv.3 
ENSMUST00000042251.11 Rmnd1 ENSMUST00000042251.11 required for meiotic nuclear division 1 homolog, transcript variant 1 (from RefSeq NM_025343.6) ENSMUST00000042251.1 ENSMUST00000042251.10 ENSMUST00000042251.2 ENSMUST00000042251.3 ENSMUST00000042251.4 ENSMUST00000042251.5 ENSMUST00000042251.6 ENSMUST00000042251.7 ENSMUST00000042251.8 ENSMUST00000042251.9 NM_025343 Q3TQK1 Q8BW19 Q8CI78 Q8R2S0 Q8VCK4 Q9CV49 Q9CVN0 RMND1_MOUSE uc007ehd.1 uc007ehd.2 uc007ehd.3 uc007ehd.4 Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome. Homooligomer. Mitochondrion Note=May be localized in mitochondrial RNA granules. Belongs to the RMD1/sif2 family. molecular_function mitochondrion translation positive regulation of mitochondrial translation uc007ehd.1 uc007ehd.2 uc007ehd.3 uc007ehd.4 
ENSMUST00000042261.5 Slc2a12 ENSMUST00000042261.5 solute carrier family 2 (facilitated glucose transporter), member 12 (from RefSeq NM_178934.4) ENSMUST00000042261.1 ENSMUST00000042261.2 ENSMUST00000042261.3 ENSMUST00000042261.4 GTR12_MOUSE Glut12 NM_178934 Q14B60 Q3UPR6 Q8BFW9 Q8BZB7 Slc2a12 uc007epo.1 uc007epo.2 uc007epo.3 uc007epo.4 Insulin-independent facilitative glucose transporter. Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, ChEBI:CHEBI:4167; Evidence=; Cell membrane ; Multi-pass membrane protein Endomembrane system ; Multi-pass membrane protein Cytoplasm, perinuclear region Note=Localizes primarily perinuclear region in the absence of insulin. Expressed in skeletal muscle, heart, brain, kidney, spleen, adipose tissues and to a lesser extent in small intestine and lung. Expression is clearly detected in ovulated oocytes and 2-cells embryos but decline day 3 morulae. Remains at very low levels between 2 dpc and 11 dpc. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. sugar:proton symporter activity protein binding cytoplasm plasma membrane integral component of plasma membrane carbohydrate transport endomembrane system membrane integral component of membrane transmembrane transporter activity perinuclear region of cytoplasm transmembrane transport hydrogen ion transmembrane transport glucose transmembrane transport uc007epo.1 uc007epo.2 uc007epo.3 uc007epo.4 
ENSMUST00000042286.12 Fmnl1 ENSMUST00000042286.12 formin-like 1, transcript variant 9 (from RefSeq NM_001403618.1) ENSMUST00000042286.1 ENSMUST00000042286.10 ENSMUST00000042286.11 ENSMUST00000042286.2 ENSMUST00000042286.3 ENSMUST00000042286.4 ENSMUST00000042286.5 ENSMUST00000042286.6 ENSMUST00000042286.7 ENSMUST00000042286.8 ENSMUST00000042286.9 FMNL1_MOUSE Frl Frl1 NM_001403618 Q6KAN4 Q9JL26 Q9Z2V7 uc007ltv.1 uc007ltv.2 uc007ltv.3 Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. May play a role in the control of cell motility and survival of macrophages. Interacts with RAC1, PFN1 and PFN2. Interacts (activated by RAC1) with SRGAP2 (via SH3 domain); regulates the actin filament severing activity of FMNL1. Q9JL26; D0ZIB5: steC; Xeno; NbExp=6; IntAct=EBI-772250, EBI-27033646; Cytoplasm Cell membrane; Lipid- anchor. Cytoplasmic vesicle, phagosome. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Frlalpha; IsoId=Q9JL26-1; Sequence=Displayed; Name=2; Synonyms=Frlbeta; IsoId=Q9JL26-2; Sequence=VSP_013978, VSP_013979, VSP_013980; Highly expressed in the spleen, lymph node and bone marrow cells. The DAD domain regulates activation via by an autoinhibitory interaction with the N-terminus. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity). Myristoylation mediates membrane localization. Belongs to the formin homology family. actin binding profilin binding cytoplasm cytosol plasma membrane substrate-dependent cell migration cytoskeleton organization regulation of cell shape cellular process membrane cellular component organization Rho GTPase binding actin cytoskeleton organization cortical actin cytoskeleton organization cytoplasmic vesicle GTPase activating protein binding phagocytic vesicle Rac GTPase binding actin filament severing actin filament binding uc007ltv.1 uc007ltv.2 uc007ltv.3 
ENSMUST00000042288.8 Asb13 ENSMUST00000042288.8 ankyrin repeat and SOCS box-containing 13, transcript variant 1 (from RefSeq NM_178283.4) ASB13_MOUSE ENSMUST00000042288.1 ENSMUST00000042288.2 ENSMUST00000042288.3 ENSMUST00000042288.4 ENSMUST00000042288.5 ENSMUST00000042288.6 ENSMUST00000042288.7 NM_178283 Q8VBX0 uc007piz.1 uc007piz.2 uc007piz.3 uc007piz.4 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Belongs to the ankyrin SOCS box (ASB) family. molecular_function cellular_component biological_process protein ubiquitination intracellular signal transduction uc007piz.1 uc007piz.2 uc007piz.3 uc007piz.4 
ENSMUST00000042290.14 Itih2 ENSMUST00000042290.14 inter-alpha trypsin inhibitor, heavy chain 2 (from RefSeq NM_010582.4) A2AKU6 ENSMUST00000042290.1 ENSMUST00000042290.10 ENSMUST00000042290.11 ENSMUST00000042290.12 ENSMUST00000042290.13 ENSMUST00000042290.2 ENSMUST00000042290.3 ENSMUST00000042290.4 ENSMUST00000042290.5 ENSMUST00000042290.6 ENSMUST00000042290.7 ENSMUST00000042290.8 ENSMUST00000042290.9 ITIH2_MOUSE NM_010582 Q3UZM0 Q61703 uc008ihq.1 uc008ihq.2 uc008ihq.3 uc008ihq.4 May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha- inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin. Secreted. Expressed in both liver and brain. Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage. Phosphorylated by FAM20C in the extracellular medium. Belongs to the ITIH family. Sequence=BAE21837.1; Type=Erroneous initiation; Evidence=; serine-type endopeptidase inhibitor activity extracellular region extracellular space negative regulation of peptidase activity negative regulation of endopeptidase activity hyaluronan metabolic process peptidase inhibitor activity uc008ihq.1 uc008ihq.2 uc008ihq.3 uc008ihq.4 
ENSMUST00000042299.4 Kcnh5 ENSMUST00000042299.4 potassium voltage-gated channel, subfamily H (eag-related), member 5 (from RefSeq NM_172805.3) E9QPM0 ENSMUST00000042299.1 ENSMUST00000042299.2 ENSMUST00000042299.3 Eag2 KCNH5_MOUSE NM_172805 Q8C035 Q920E3 uc007nwz.1 uc007nwz.2 uc007nwz.3 uc007nwz.4 Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG (By similarity). Membrane; Multi-pass membrane protein. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity calmodulin binding integral component of plasma membrane ion transport potassium ion transport cell surface regulation of G2/M transition of mitotic cell cycle membrane integral component of membrane regulation of ion transmembrane transport regulation of membrane potential ion channel binding protein heterodimerization activity transmembrane transport potassium ion transmembrane transport uc007nwz.1 uc007nwz.2 uc007nwz.3 uc007nwz.4 
ENSMUST00000042312.14 Trafd1 ENSMUST00000042312.14 TRAF type zinc finger domain containing 1, transcript variant 1 (from RefSeq NM_001163470.1) ENSMUST00000042312.1 ENSMUST00000042312.10 ENSMUST00000042312.11 ENSMUST00000042312.12 ENSMUST00000042312.13 ENSMUST00000042312.2 ENSMUST00000042312.3 ENSMUST00000042312.4 ENSMUST00000042312.5 ENSMUST00000042312.6 ENSMUST00000042312.7 ENSMUST00000042312.8 ENSMUST00000042312.9 Fln29 NM_001163470 Q3UDK1 Q8CFI8 TRAD1_MOUSE uc008ziz.1 uc008ziz.2 uc008ziz.3 uc008ziz.4 Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3. Interacts with MAVS, TICAM1, TRAF1, TRAF2, TRAF3 and TRAF6. Q3UDK1; P70196: Traf6; NbExp=2; IntAct=EBI-1396948, EBI-448028; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UDK1-1; Sequence=Displayed; Name=2; IsoId=Q3UDK1-2; Sequence=VSP_023294; Expressed in skeletal muscle, brain, liver, kidney, spleen and bone marrow. Expression depends on STAT1. By lipopolysaccharide (LPS), IFNB1 and IFNG, IFNB1 being most rapid and potent inducer (at protein level). Not induced by anti- inflammatory cytokines, such as IL4 and IL10, which also inhibit LPS induction of TRAFD1. Mice show no gross developmental abnormalities, but exhibit an increased susceptibility to LPS-induced septic shock and are more sensitive to poly(I:C) shock, suffering more severe hepatic damage than wild-type animals. In response to LPS-stimulation, bone marrow-derived dendritic cells display an increased production of pro- inflammatory cytokines, such as IL6, TNF and IL12, as well as elevated IKK and JNK activation, compared to wild-type mice. Mutant embryonic fibroblasts are more resistant to vesicular stomatitis virus (VSV)- induced cytopathic effect. protein binding cellular_component zinc ion binding negative regulation of innate immune response metal ion binding uc008ziz.1 uc008ziz.2 uc008ziz.3 uc008ziz.4 
ENSMUST00000042318.6 Fsd2 ENSMUST00000042318.6 fibronectin type III and SPRY domain containing 2 (from RefSeq NM_172904.2) A0A140T8J1 E9QMV0 ENSMUST00000042318.1 ENSMUST00000042318.2 ENSMUST00000042318.3 ENSMUST00000042318.4 ENSMUST00000042318.5 FSD2_MOUSE NM_172904 Q8BZ52 Spryd1 uc009icd.1 uc009icd.2 uc009icd.3 Interacts with CMYA5 (PubMed:28740084). In cardiac muscles, identified in a complex composed of FSD2, CMYA5 and RYR2 (PubMed:28740084). Nucleus Sarcoplasmic reticulum Cytoplasm, perinuclear region Note=In skeletal muscles and striated muscles flanks Z-disks. Partially colocalizes with RYR2 in the sarcoplasmic reticulum. Expressed predominantly in heart and skeletal muscle (at protein level). Sequence=BAC29530.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding nucleus cytoplasm biological_process sarcoplasmic reticulum perinuclear region of cytoplasm uc009icd.1 uc009icd.2 uc009icd.3 
ENSMUST00000042329.12 Nxt2 ENSMUST00000042329.12 nuclear transport factor 2-like export factor 2, transcript variant 2 (from RefSeq NM_001161430.2) B1AVX3 B1AVX5 ENSMUST00000042329.1 ENSMUST00000042329.10 ENSMUST00000042329.11 ENSMUST00000042329.2 ENSMUST00000042329.3 ENSMUST00000042329.4 ENSMUST00000042329.5 ENSMUST00000042329.6 ENSMUST00000042329.7 ENSMUST00000042329.8 ENSMUST00000042329.9 NM_001161430 NXT2_MOUSE Q3UNA4 Q505F8 Q6NVE1 Q8C070 uc012hpq.1 uc012hpq.2 uc012hpq.3 uc012hpq.4 Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (By similarity). Associates with NXF1, NXF2, NXF3 and NXF5. Nucleus Cytoplasm Note=Shuttles between the nucleus and the cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UNA4-1; Sequence=Displayed; Name=2; IsoId=Q3UNA4-2; Sequence=VSP_037529; Name=3; IsoId=Q3UNA4-3; Sequence=VSP_037528; protein binding nucleus nucleoplasm cytoplasm cytosol protein import into nucleus nucleocytoplasmic transport protein transport nuclear pore central transport channel perinuclear region of cytoplasm mRNA transport uc012hpq.1 uc012hpq.2 uc012hpq.3 uc012hpq.4 
ENSMUST00000042334.16 Rpl10a ENSMUST00000042334.16 ribosomal protein L10A, transcript variant 1 (from RefSeq NM_011287.3) ENSMUST00000042334.1 ENSMUST00000042334.10 ENSMUST00000042334.11 ENSMUST00000042334.12 ENSMUST00000042334.13 ENSMUST00000042334.14 ENSMUST00000042334.15 ENSMUST00000042334.2 ENSMUST00000042334.3 ENSMUST00000042334.4 ENSMUST00000042334.5 ENSMUST00000042334.6 ENSMUST00000042334.7 ENSMUST00000042334.8 ENSMUST00000042334.9 NM_011287 Q5XJF6 Q5XJF6_MOUSE Rpl10a uc008bqp.1 uc008bqp.2 uc008bqp.3 Belongs to the universal ribosomal protein uL1 family. cytoplasmic translation RNA binding structural constituent of ribosome ribosome translation large ribosomal subunit cytosolic large ribosomal subunit polysomal ribosome uc008bqp.1 uc008bqp.2 uc008bqp.3 
ENSMUST00000042344.2 4930556J24Rik ENSMUST00000042344.2 4930556J24Rik (from geneSymbol) 4930556J24Rik AK016148 ENSMUST00000042344.1 Q9D4U7 Q9D4U7_MOUSE uc287wft.1 uc287wft.2 molecular_function cellular_component biological_process uc287wft.1 uc287wft.2 
ENSMUST00000042345.8 Ctnna1 ENSMUST00000042345.8 catenin alpha 1 (from RefSeq NM_009818.1) Ctnna1 ENSMUST00000042345.1 ENSMUST00000042345.2 ENSMUST00000042345.3 ENSMUST00000042345.4 ENSMUST00000042345.5 ENSMUST00000042345.6 ENSMUST00000042345.7 NM_009818 Q545R0 Q545R0_MOUSE uc008ely.1 uc008ely.2 uc008ely.3 uc008ely.4 Cell junction, adherens junction Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the vinculin/alpha-catenin family. ovarian follicle development acrosomal vesicle structural molecule activity cytoplasm Golgi apparatus plasma membrane cell-cell junction cell-cell adherens junction cell adhesion aging beta-catenin binding male gonad development response to organic cyclic compound actin cytoskeleton gap junction assembly catenin complex vinculin binding cell junction axon regeneration odontogenesis of dentin-containing tooth identical protein binding intracellular membrane-bounded organelle response to estrogen gamma-catenin binding cadherin binding actin filament binding protein heterooligomerization cellular response to indole-3-methanol uc008ely.1 uc008ely.2 uc008ely.3 uc008ely.4 
ENSMUST00000042352.11 Zmat4 ENSMUST00000042352.11 zinc finger, matrin type 4, transcript variant 1 (from RefSeq NM_177086.4) ENSMUST00000042352.1 ENSMUST00000042352.10 ENSMUST00000042352.2 ENSMUST00000042352.3 ENSMUST00000042352.4 ENSMUST00000042352.5 ENSMUST00000042352.6 ENSMUST00000042352.7 ENSMUST00000042352.8 ENSMUST00000042352.9 NM_177086 Q3USG2 Q6AXC5 Q8BZ94 ZMAT4_MOUSE uc009lew.1 uc009lew.2 uc009lew.3 uc009lew.4 uc009lew.5 uc009lew.6 Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BZ94-1; Sequence=Displayed; Name=2; IsoId=Q8BZ94-2; Sequence=VSP_027477; Name=3; IsoId=Q8BZ94-3; Sequence=VSP_027478; nucleic acid binding DNA binding nucleus zinc ion binding metal ion binding uc009lew.1 uc009lew.2 uc009lew.3 uc009lew.4 uc009lew.5 uc009lew.6 
ENSMUST00000042360.5 Capsl ENSMUST00000042360.5 calcyphosine-like, transcript variant 1 (from RefSeq NM_029341.2) CAPSL_MOUSE ENSMUST00000042360.1 ENSMUST00000042360.2 ENSMUST00000042360.3 ENSMUST00000042360.4 NM_029341 Q5U5X2 Q6P8Y1 Q9D9U6 uc007vfn.1 uc007vfn.2 uc007vfn.3 Cytoplasm Sequence=AAH37621.1; Type=Erroneous initiation; Evidence=; Sequence=BAB24601.1; Type=Erroneous initiation; Evidence=; calcium ion binding cellular_component cytoplasm biological_process metal ion binding uc007vfn.1 uc007vfn.2 uc007vfn.3 
ENSMUST00000042365.9 Cdk13 ENSMUST00000042365.9 cyclin dependent kinase 13, transcript variant 1 (from RefSeq NM_001081058.2) CDK13_MOUSE Cdc2l5 E9QKZ6 ENSMUST00000042365.1 ENSMUST00000042365.2 ENSMUST00000042365.3 ENSMUST00000042365.4 ENSMUST00000042365.5 ENSMUST00000042365.6 ENSMUST00000042365.7 ENSMUST00000042365.8 Kiaa1791 NM_001081058 Q69ZA1 Q80V11 Q8BZG1 Q8K0A4 uc007poc.1 uc007poc.2 uc007poc.3 uc007poc.4 Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. Reaction=[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho- [DNA-directed RNA polymerase]; Xref=Rhea:RHEA:10216, Rhea:RHEA- COMP:11321, Rhea:RHEA-COMP:11322, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.23; Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Interacts with C1QBP (By similarity). Interacts with CCNK, CCNL1 and CCNL2. Nucleus speckle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69ZA1-1; Sequence=Displayed; Name=2; IsoId=Q69ZA1-2; Sequence=VSP_013580; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Sequence=AAH32179.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC29077.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC29077.1; Type=Frameshift; Evidence=; Sequence=BAD32543.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding cyclin-dependent protein kinase holoenzyme complex alternative mRNA splicing, via spliceosome nuclear chromatin cyclin K-CDK13 complex protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus chromosome Golgi apparatus cytosol transcription elongation from RNA polymerase II promoter mRNA processing protein phosphorylation cyclin/CDK positive transcription elongation factor complex transcription factor binding RNA polymerase II carboxy-terminal domain kinase activity RNA splicing kinase activity phosphorylation nuclear speck transferase activity protein kinase binding nuclear cyclin-dependent protein kinase holoenzyme complex hemopoiesis cyclin binding positive regulation of transcription elongation from RNA polymerase II promoter transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter regulation of cell cycle phosphorylation of RNA polymerase II C-terminal domain negative regulation of stem cell differentiation uc007poc.1 uc007poc.2 uc007poc.3 uc007poc.4 
ENSMUST00000042373.12 Shcbp1l ENSMUST00000042373.12 Shc SH2-domain binding protein 1-like (from RefSeq NM_001033162.2) ENSMUST00000042373.1 ENSMUST00000042373.10 ENSMUST00000042373.11 ENSMUST00000042373.2 ENSMUST00000042373.3 ENSMUST00000042373.4 ENSMUST00000042373.5 ENSMUST00000042373.6 ENSMUST00000042373.7 ENSMUST00000042373.8 ENSMUST00000042373.9 NM_001033162 Q3TTP0 SHP1L_MOUSE Shcbp1l uc007czx.1 uc007czx.2 uc007czx.3 Testis-specific spindle-associated factor that plays a role in spermatogenesis (PubMed:24557841). In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells (PubMed:24557841). Interacts with HSPA2; this interaction may promote the recruitment of HSPA2 to the spindle (PubMed:24557841). Cytoplasm, cytoskeleton, spindle Note=Colocalizes with alpha tubulin during meiosis (PubMed:24557841). Colocalizes with HSPA2 at spindle during the meiosis process (PubMed:24557841). Expressed in pachytene spermatocytes and elongating spermatids inside the seminiferous tubules (PubMed:24557841). Not detected in ovary (at protein level) (PubMed:24557841). Testis-specific (PubMed:24557841). Male mice exhibit decreased fertility and produce reduced epididymal sperm content, but do not influence the rates of motility, capacitation and acrosome reaction of sperm (PubMed:24557841). Meiosis-arrested spermatocytes are increased in the early stages of meiosis and undergo programmed cell death (PubMed:24557841). Display a diminution of the HSPA2 signal at the spindle and disordered chromosomes during male meiosis (PubMed:24557841). protein binding cytoplasm spindle cytoskeleton male meiosis cytokinesis spermatogenesis cell differentiation meiotic spindle positive regulation of chromosome organization uc007czx.1 uc007czx.2 uc007czx.3 
ENSMUST00000042390.5 Man1b1 ENSMUST00000042390.5 mannosidase, alpha, class 1B, member 1 (from RefSeq NM_001029983.2) A2AJ15 ENSMUST00000042390.1 ENSMUST00000042390.2 ENSMUST00000042390.3 ENSMUST00000042390.4 MA1B1_MOUSE NM_001029983 uc008irp.1 uc008irp.2 uc008irp.3 uc008irp.4 Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) (By similarity). Reaction=4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- (1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = 4 beta-D-mannose + N(4)-(alpha-D-Man- (1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]- beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl- [protein] (N-glucan mannose isomer 5A1,2); Xref=Rhea:RHEA:56008, Rhea:RHEA-COMP:14356, Rhea:RHEA-COMP:14367, ChEBI:CHEBI:15377, ChEBI:CHEBI:28563, ChEBI:CHEBI:59087, ChEBI:CHEBI:139493; EC=3.2.1.113; Evidence=; Reaction=3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man- (1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D- Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man- (1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2); Xref=Rhea:RHEA:56028, Rhea:RHEA- COMP:14358, Rhea:RHEA-COMP:14367, ChEBI:CHEBI:15377, ChEBI:CHEBI:28563, ChEBI:CHEBI:59087, ChEBI:CHEBI:60628; EC=3.2.1.113; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Belongs to the glycosyl hydrolase 47 family. catalytic activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity calcium ion binding endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation N-glycan processing metabolic process membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds ER-associated ubiquitin-dependent protein catabolic process protein alpha-1,2-demannosylation trimming of terminal mannose on B branch endoplasmic reticulum quality control compartment metal ion binding endoplasmic reticulum mannose trimming mannose trimming involved in glycoprotein ERAD pathway uc008irp.1 uc008irp.2 uc008irp.3 uc008irp.4 
ENSMUST00000042391.13 Fdxacb1 ENSMUST00000042391.13 ferredoxin-fold anticodon binding domain containing 1 (from RefSeq NM_198675.2) ENSMUST00000042391.1 ENSMUST00000042391.10 ENSMUST00000042391.11 ENSMUST00000042391.12 ENSMUST00000042391.2 ENSMUST00000042391.3 ENSMUST00000042391.4 ENSMUST00000042391.5 ENSMUST00000042391.6 ENSMUST00000042391.7 ENSMUST00000042391.8 ENSMUST00000042391.9 FDXA1_MOUSE NM_198675 Q14B93 Q3UY23 Q8BUG6 Q8BZH7 uc009pkq.1 uc009pkq.2 uc009pkq.3 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UY23-1; Sequence=Displayed; Name=2; IsoId=Q3UY23-2; Sequence=VSP_032500, VSP_032501; Name=3; IsoId=Q3UY23-3; Sequence=VSP_032499; cytoplasm rRNA (uridine-N3-)-methyltransferase activity rRNA base methylation uc009pkq.1 uc009pkq.2 uc009pkq.3 
ENSMUST00000042405.8 Fbl ENSMUST00000042405.8 fibrillarin, transcript variant 1 (from RefSeq NM_007991.4) ENSMUST00000042405.1 ENSMUST00000042405.2 ENSMUST00000042405.3 ENSMUST00000042405.4 ENSMUST00000042405.5 ENSMUST00000042405.6 ENSMUST00000042405.7 FBRL_MOUSE Fbl NM_007991 P35550 Q99L58 uc009fxy.1 uc009fxy.2 uc009fxy.3 S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (PubMed:32017896). Involved in pre-rRNA processing by catalyzing the site-specific 2'- hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity). Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes (PubMed:32017896). U6 snRNA 2'-O- methylation is required for mRNA splicing fidelity (PubMed:32017896). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Reaction=L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:50904, Rhea:RHEA-COMP:12837, Rhea:RHEA-COMP:12839, ChEBI:CHEBI:15378, ChEBI:CHEBI:30011, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61891; Evidence=; Reaction=a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O- methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48628, Rhea:RHEA-COMP:12164, Rhea:RHEA-COMP:12165, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90675, ChEBI:CHEBI:90676; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48629; Evidence=; Reaction=a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine = a 2'- O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:63088, Rhea:RHEA-COMP:16262, Rhea:RHEA- COMP:16263, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90675, ChEBI:CHEBI:90676; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63089; Evidence=; Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles that contain SNU13, FBL, NOP5 and NOP56, plus a guide RNA. It is associated with the U3, U8, U13, X and Y small nuclear RNAs. Component of several ribosomal and nucleolar protein complexes. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Interacts with PRMT5 and UTP20. Interacts with DDX5 and C1QBP. Interacts with NOL11. Interacts with PIH1D1. Interacts with RRP1B (By similarity). Interacts with NOLC1 (By similarity). Interacts with SDE2 (By similarity). Nucleus, nucleolus Nucleus, nucleoplasm Note=Fibrillar region of the nucleolus. By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA). Ubiquitinated. Ubiquitination leads to proteasomal degradation. Deubiquitinated by USP36. Acetylated by CREBBP/CBP, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me), without affecting rRNA methylation. Deacetylation by SIRT7 restores methylation of 'Gln-105' of histone H2A (H2AQ104me). Belongs to the methyltransferase superfamily. Fibrillarin family. box C/D snoRNA 3'-end processing TFIID-class transcription factor binding fibrillar center dense fibrillar component granular component RNA binding nucleus nucleoplasm chromosome nucleolus rRNA processing methyltransferase activity rRNA methyltransferase activity Cajal body snoRNA metabolic process transferase activity rRNA methylation box C/D snoRNP complex small-subunit processome methylation snoRNA localization ATPase binding histone glutamine methylation histone-glutamine methyltransferase activity uc009fxy.1 uc009fxy.2 uc009fxy.3 
ENSMUST00000042412.5 Hey1 ENSMUST00000042412.5 hairy/enhancer-of-split related with YRPW motif 1 (from RefSeq NM_010423.2) ENSMUST00000042412.1 ENSMUST00000042412.2 ENSMUST00000042412.3 ENSMUST00000042412.4 Hey1 Hrt1 NM_010423 Q9QUM5 Q9QUM5_MOUSE uc008oop.1 uc008oop.2 uc008oop.3 Nucleus Belongs to the HEY family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding angiogenesis DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated Notch signaling pathway negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated protein dimerization activity negative regulation of transcription regulatory region DNA binding negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation uc008oop.1 uc008oop.2 uc008oop.3 
ENSMUST00000042444.7 Arhgap36 ENSMUST00000042444.7 Arhgap36 (from geneSymbol) AK048167 Arhgap36 ENSMUST00000042444.1 ENSMUST00000042444.2 ENSMUST00000042444.3 ENSMUST00000042444.4 ENSMUST00000042444.5 ENSMUST00000042444.6 Z4YJK0 Z4YJK0_MOUSE uc292obj.1 uc292obj.2 signal transduction uc292obj.1 uc292obj.2 
ENSMUST00000042456.4 B3galt1 ENSMUST00000042456.4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1, transcript variant 7 (from RefSeq NM_020283.4) B3galt1 ENSMUST00000042456.1 ENSMUST00000042456.2 ENSMUST00000042456.3 NM_020283 Q505A3 Q505A3_MOUSE RP23-27J1.2-001 uc033hnj.1 uc033hnj.2 uc033hnj.3 Reaction=a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)- Cer(d18:1(4E)) + UDP-alpha-D-galactose = a beta-D-Gal-(1->3)-beta-D- GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:16045, ChEBI:CHEBI:15378, ChEBI:CHEBI:17103, ChEBI:CHEBI:17292, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914; EC=2.4.1.86; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16046; Evidence=; Reaction=an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D- galactose = a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:53432, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:61631, ChEBI:CHEBI:66914, ChEBI:CHEBI:133506; EC=2.4.1.86; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53433; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein mbrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 31 family. Golgi membrane Golgi apparatus protein glycosylation galactosylceramide biosynthetic process galactosyltransferase activity UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity oligosaccharide biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups lipid glycosylation uc033hnj.1 uc033hnj.2 uc033hnj.3 
ENSMUST00000042468.9 Cfap68 ENSMUST00000042468.9 cilia and flagella associated protein 68, transcript variant 1 (from RefSeq NM_023483.4) CFA68_MOUSE ENSMUST00000042468.1 ENSMUST00000042468.2 ENSMUST00000042468.3 ENSMUST00000042468.4 ENSMUST00000042468.5 ENSMUST00000042468.6 ENSMUST00000042468.7 ENSMUST00000042468.8 NM_023483 Q3TM17 Q3TYP3 Q4FK47 Q8K0A6 Q9D131 Q9D589 Q9JHT0 uc009pkp.1 uc009pkp.2 uc009pkp.3 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Nucleus Cytoplasm, cytoskeleton, cilium axoneme Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D131-1; Sequence=Displayed; Name=2; IsoId=Q9D131-2; Sequence=VSP_027584; Belongs to the CFAP68 family. molecular_function nucleus nucleoplasm biological_process uc009pkp.1 uc009pkp.2 uc009pkp.3 
ENSMUST00000042470.14 Zkscan2 ENSMUST00000042470.14 zinc finger with KRAB and SCAN domains 2 (from RefSeq NM_001081329.2) ENSMUST00000042470.1 ENSMUST00000042470.10 ENSMUST00000042470.11 ENSMUST00000042470.12 ENSMUST00000042470.13 ENSMUST00000042470.2 ENSMUST00000042470.3 ENSMUST00000042470.4 ENSMUST00000042470.5 ENSMUST00000042470.6 ENSMUST00000042470.7 ENSMUST00000042470.8 ENSMUST00000042470.9 G3X952 G3X952_MOUSE NM_001081329 Zkscan2 uc009jps.1 uc009jps.2 uc009jps.3 uc009jps.4 uc009jps.5 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009jps.1 uc009jps.2 uc009jps.3 uc009jps.4 uc009jps.5 
ENSMUST00000042471.11 Dis3 ENSMUST00000042471.11 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease, transcript variant 1 (from RefSeq NM_028315.2) ENSMUST00000042471.1 ENSMUST00000042471.10 ENSMUST00000042471.2 ENSMUST00000042471.3 ENSMUST00000042471.4 ENSMUST00000042471.5 ENSMUST00000042471.6 ENSMUST00000042471.7 ENSMUST00000042471.8 ENSMUST00000042471.9 Kiaa1008 NM_028315 Q6ZQ07 Q8C074 Q9CSH3 RRP44_MOUSE Rrp44 uc007uuw.1 uc007uuw.2 uc007uuw.3 Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Component of the RNA exosome complex (By similarity). The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms (By similarity). Interacts with DHX34; the interaction is RNA-independent (By similarity). Cytoplasm Nucleus, nucleolus Nucleus, nucleoplasm Nucleus Note=Predominantly located in the nucleus. According to, found in the nucleolus. According to, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3. Belongs to the RNR ribonuclease family. Sequence=BAC98069.1; Type=Miscellaneous discrepancy; Note=Incompletely spliced mRNA.; Evidence=; 3'-5'-exoribonuclease activity nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) RNA binding nuclease activity endonuclease activity exonuclease activity ribonuclease activity guanyl-nucleotide exchange factor activity nucleus nucleoplasm nucleolus cytoplasm cytosol rRNA processing rRNA catabolic process hydrolase activity CUT catabolic process nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic uc007uuw.1 uc007uuw.2 uc007uuw.3 
ENSMUST00000042477.13 Vps25 ENSMUST00000042477.13 vacuolar protein sorting 25, transcript variant 2 (from RefSeq NM_026776.5) A2A4J9 A2A4K1 D11Wsu68e ENSMUST00000042477.1 ENSMUST00000042477.10 ENSMUST00000042477.11 ENSMUST00000042477.12 ENSMUST00000042477.2 ENSMUST00000042477.3 ENSMUST00000042477.4 ENSMUST00000042477.5 ENSMUST00000042477.6 ENSMUST00000042477.7 ENSMUST00000042477.8 ENSMUST00000042477.9 NM_026776 Q3UBT0 Q9CQ80 Q9D167 VPS25_MOUSE uc007lod.1 uc007lod.2 uc007lod.3 uc007lod.4 Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL (By similarity). Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS36 and 2 copies of VPS25. Interacts with CFTR; the interaction requires misfolded CFTR. Interacts (via C-terminal half) with the ESCRT-III subunit CHMP6 (via N-terminal half) (By similarity). Cytoplasm Endosome membrane Nucleus Note=Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQ80-1; Sequence=Displayed; Name=2; IsoId=Q9CQ80-2; Sequence=VSP_015341; Belongs to the VPS25 family. ESCRT II complex structural molecule activity nucleus cytoplasm mitochondrion endosome cytosol negative regulation of epidermal growth factor-activated receptor activity endosome membrane protein transport membrane protein homodimerization activity protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein N-terminus binding multivesicular body sorting pathway uc007lod.1 uc007lod.2 uc007lod.3 uc007lod.4 
ENSMUST00000042485.11 AW551984 ENSMUST00000042485.11 expressed sequence AW551984, transcript variant 2 (from RefSeq NM_178737.5) AW551984 ENSMUST00000042485.1 ENSMUST00000042485.10 ENSMUST00000042485.2 ENSMUST00000042485.3 ENSMUST00000042485.4 ENSMUST00000042485.5 ENSMUST00000042485.6 ENSMUST00000042485.7 ENSMUST00000042485.8 ENSMUST00000042485.9 NM_178737 Q8BGF0 Q8BGF0_MOUSE uc009oyf.1 uc009oyf.2 molecular_function cellular_component cardiac muscle cell differentiation cardiac muscle cell fate commitment uc009oyf.1 uc009oyf.2 
ENSMUST00000042493.10 Ccdc115 ENSMUST00000042493.10 coiled-coil domain containing 115 (from RefSeq NM_027159.2) CC115_MOUSE ENSMUST00000042493.1 ENSMUST00000042493.2 ENSMUST00000042493.3 ENSMUST00000042493.4 ENSMUST00000042493.5 ENSMUST00000042493.6 ENSMUST00000042493.7 ENSMUST00000042493.8 ENSMUST00000042493.9 NM_027159 Q3TS67 Q8VE99 uc011wja.1 uc011wja.2 Accessory component of the proton-transporting vacuolar (V)- ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity). Accessory component of the multisubunit proton-transporting vacuolar (V)-ATPase protein pump. Endosome Lysosome Endoplasmic reticulum-Golgi intermediate compartment Cytoplasmic vesicle, COPI- coated vesicle Endoplasmic reticulum Note=Seems not to be associated with recycling endosomes. Predominantly expressed in the heart, liver, kidney and testis and at lower levels in the brain and lung. Undetectable in the spleen and muscles. Strongly expressed at 13.5 dpc in a ventro-lateral area of striatum and piriform cortex. At 14.5 dpc, some of the positive cells shift toward the cortical plate. At this stage, strongly observed at the superficial layer of dorsal cortex, whereas that of ventral cortex decreases in its intensity. Expression extended further dorsally at 16.5 dpc. In the dorsal cortex, expressed in the ventricular zone at 13.5 dpc. At later stages, expression shifts to the cortical plate. At 15.5 dpc, localizes to both ventricular zone and cortical plate. At 16.5 dpc, almost all expression is in the deeper cortical plate, although some expressing cells are still detectable in the ventricular zone. In the lateral cortex, weak expression in the lateral ganglionic eminence at 13.5 dpc. At 15.5 dpc, strongly detected in the progenitor zones of the lateral ganglionic eminence and medial ganglionic eminence, as well as in tangentially migrating cells in the superficial area of lateral cortex. In the striatum and ventro-lateral cortex, expressed at both 13.5 dpc and 15.5 dpc. Modestly up-regulated by FGF2. lysosome endosome endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment cellular iron ion homeostasis lysosomal lumen acidification vacuolar proton-transporting V-type ATPase complex COPI-coated vesicle cytoplasmic vesicle cellular response to increased oxygen levels extrinsic component of endoplasmic reticulum membrane unfolded protein binding vacuolar proton-transporting V-type ATPase complex assembly lysosomal protein catabolic process uc011wja.1 uc011wja.2 
ENSMUST00000042497.14 Ndufv1 ENSMUST00000042497.14 NADH:ubiquinone oxidoreductase core subunit V1 (from RefSeq NM_133666.3) ENSMUST00000042497.1 ENSMUST00000042497.10 ENSMUST00000042497.11 ENSMUST00000042497.12 ENSMUST00000042497.13 ENSMUST00000042497.2 ENSMUST00000042497.3 ENSMUST00000042497.4 ENSMUST00000042497.5 ENSMUST00000042497.6 ENSMUST00000042497.7 ENSMUST00000042497.8 ENSMUST00000042497.9 NDUV1_MOUSE NM_133666 Ndufv1 Q91YT0 uc008fye.1 uc008fye.2 uc008fye.3 uc008fye.4 This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The human ortholog of this protein has been characterized. It has consensus motifs for NADH, flavin mononucleotide, and iron-sulfur binding sites and participates in the oxidation of NADH as part of the dehydrogenase module of complex I. In humans, deficiencies in complex I are associated with myopathies, encephalomyopathies, and neurodegenerative disorders. [provided by RefSeq, Jun 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014818.1, AK005021.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 23038253; reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains FMN, which is the initial electron acceptor as well as one iron-sulfur cluster. Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29092; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Note=Binds 1 FMN. ; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (PubMed:29915388). This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (PubMed:29915388). Interacts with RAB5IF (PubMed:31536960). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the complex I 51 kDa subunit family. NADH dehydrogenase activity protein binding mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I cytosol mitochondrial electron transport, NADH to ubiquinone NADH dehydrogenase (ubiquinone) activity FMN binding membrane oxidoreductase activity oxidoreductase activity, acting on NAD(P)H mitochondrial ATP synthesis coupled electron transport metal ion binding NAD binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding oxidation-reduction process respiratory chain uc008fye.1 uc008fye.2 uc008fye.3 uc008fye.4 
ENSMUST00000042512.8 Kin ENSMUST00000042512.8 Kin17 DNA and RNA binding protein, transcript variant 1 (from RefSeq NM_025280.3) Btcd ENSMUST00000042512.1 ENSMUST00000042512.2 ENSMUST00000042512.3 ENSMUST00000042512.4 ENSMUST00000042512.5 ENSMUST00000042512.6 ENSMUST00000042512.7 KIN17_MOUSE Kin Kin17 NM_025280 Q8K339 Q9CV58 uc008ihp.1 uc008ihp.2 uc008ihp.3 Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C- terminal domain to RNA in vitro. Associated with DNA polymerase alpha, RFC1 and cyclin A, in multiprotein DNA replication complexes. Also associates with replication origins at the G1/S phase boundary and throughout the S phase in vivo (By similarity). Nucleus Cytoplasm Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. Highly expressed in transformed mouse AtT20 neuroendocrine cells. Expressed at a lower level in testis, kidney, skeletal muscle, liver, lung, spleen, brain and heart and kidney. In testis, expressed at much higher levels in proliferating cells than in differentiating cells. Not detected in embryo. In testis, expression almost doubled from day 5 to days 17-22 postpartum (dpp) and then decreased by 28 dpp to reach a stable level in adult testis. The C-terminal domain (268-393) is organized into 2 subdomains that bear structural similarities to SH3-like domains. Both subdomains adopt a similar 5-stranded beta-barrel-like fold and are connected to each other by a short linker of 5 residues. The 5 beta-sheets are packed at approximately right angles against each other. A highly conserved groove formed at the interface between the 2 subdomains, comprised of Lys residues 302 and 391 and other positively charged residues, may possibly be the site of RNA-binding (By similarity). Recognized by antibodies directed against the RecA protein. Belongs to the KIN17 family. DNA binding double-stranded DNA binding RNA binding nucleus cytoplasm DNA replication DNA repair DNA recombination mRNA processing cellular response to DNA damage stimulus nuclear matrix macromolecular complex intracellular membrane-bounded organelle metal ion binding uc008ihp.1 uc008ihp.2 uc008ihp.3 
ENSMUST00000042530.4 Gucy2f ENSMUST00000042530.4 guanylate cyclase 2f (from RefSeq NM_001007576.2) ENSMUST00000042530.1 ENSMUST00000042530.2 ENSMUST00000042530.3 GUC2F_MOUSE Gucy2f NM_001007576 Q5SDA5 Q8BLL8 uc033jum.1 uc033jum.2 uc033jum.3 uc033jum.4 Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (By similarity). Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (PubMed:17255100). Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2; Evidence=; Activated by GUCA1B when free calcium ions concentration is low, and inhibited by GUCA1B when free calcium ions concentration is high (By similarity). Inhibited by RD3 (By similarity). Homodimer (By similarity). Interacts with RD3; promotes the exit of GUCY2F from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (PubMed:21078983). Membrane ; Single- pass type I membrane protein Photoreceptor outer segment membrane ; Single-pass type I membrane protein Retina. The protein kinase domain is predicted to be catalytically inactive. There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds. Deficient mice exhibit normal retinal morphology. Electroretinography shows slower recovery of rod from intense illumination. GUCY2F and GUCY2E double knockout mice does not show any photoresponse at 4 weeks of age, rods and cones degenerate at about 2 month of age and the intracellular transport of some phototransduction proteins is impaired. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding peptide receptor activity guanylate cyclase activity protein kinase activity ATP binding GTP binding plasma membrane cGMP biosynthetic process protein phosphorylation signal transduction receptor guanylyl cyclase signaling pathway visual perception cyclic nucleotide biosynthetic process membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity natriuretic peptide receptor activity peptide hormone binding cGMP-mediated signaling intracellular signal transduction protein homodimerization activity protein heterodimerization activity response to stimulus detection of light stimulus involved in visual perception uc033jum.1 uc033jum.2 uc033jum.3 uc033jum.4 
ENSMUST00000042546.4 Ano10 ENSMUST00000042546.4 anoctamin 10, transcript variant 1 (from RefSeq NM_133979.4) ANO10_MOUSE ENSMUST00000042546.1 ENSMUST00000042546.2 ENSMUST00000042546.3 NM_133979 Q4FZD2 Q8BH79 Q8BMS8 Q8BV74 Q8BW67 Q8R0U0 Q99LP0 Tmem16k uc009ser.1 uc009ser.2 uc009ser.3 This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to inhibit anion conductance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]. Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1 (By similarity). Cell membrane ; Multi-pass membrane protein Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BH79-1; Sequence=Displayed; Name=2; IsoId=Q8BH79-2; Sequence=VSP_026034; Name=3; IsoId=Q8BH79-3; Sequence=VSP_026035, VSP_026036; Name=4; IsoId=Q8BH79-4; Sequence=VSP_026037; Predominant expression seen in epithelial tissues. Detected in the mantle layer of the neural tube and in the dorsal root ganglia at 14.5 dpc. The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. Belongs to the anoctamin family. Sequence=AAH26421.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence=; Sequence=BAC25927.1; Type=Frameshift; Evidence=; Sequence=BAC37706.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; calcium activated cation channel activity intracellular calcium activated chloride channel activity plasma membrane cation transport chloride transport membrane integral component of membrane ion transmembrane transport uc009ser.1 uc009ser.2 uc009ser.3 
ENSMUST00000042553.8 A4gnt ENSMUST00000042553.8 alpha-1,4-N-acetylglucosaminyltransferase (from RefSeq NM_001077424.2) A4GCT_MOUSE A4gnt ENSMUST00000042553.1 ENSMUST00000042553.2 ENSMUST00000042553.3 ENSMUST00000042553.4 ENSMUST00000042553.5 ENSMUST00000042553.6 ENSMUST00000042553.7 NM_001077424 Q14BT6 uc009rej.1 uc009rej.2 uc009rej.3 This gene encodes a protein from the glycosyltransferase 32 family. The encoded enzyme catalyzes the transfer of N-acetylglucosamine to alpha-1,4-linked beta-galactose residues. This enzyme is required for type III mucin synthesis and it is largely associated with the Golgi apparatus membrane. The encoded protein appears to be expressed in adenocarcinoma cells of pancreatic, biliary tract and gastric cancers.[provided by RefSeq, Jan 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK136425.1, BY708771.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct. May protect against inflammation-associated gastric adenocarcinoma. Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein The conserved DXD motif is involved in enzyme activity. Viable with no gross defects. Gastric mucosa cells and duodenal Brunner's glands have an altered O-linked glycosylation profile with complete loss of terminal alpha-1,4-linked N-acetylglucosamine residues (alpha-GlcNAc). Animals develop spontaneous gastric adenocarcinomas, with all individuals affected by 60 weeks of age. Hyperplasia of surface mucous cells and pyloric gland cells is observed as early as 5 weeks of age, associated with increased inflammatory responses in the gastric mucosa. Belongs to the glycosyltransferase 32 family. Golgi membrane cellular_component Golgi apparatus protein glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity glycoprotein biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups negative regulation of epithelial cell proliferation uc009rej.1 uc009rej.2 uc009rej.3 
ENSMUST00000042556.11 Pwp2 ENSMUST00000042556.11 PWP2 periodic tryptophan protein homolog (yeast) (from RefSeq NM_029546.2) ENSMUST00000042556.1 ENSMUST00000042556.10 ENSMUST00000042556.2 ENSMUST00000042556.3 ENSMUST00000042556.4 ENSMUST00000042556.5 ENSMUST00000042556.6 ENSMUST00000042556.7 ENSMUST00000042556.8 ENSMUST00000042556.9 NM_029546 PWP2_MOUSE Pwp2h Q8BTR0 Q8BU03 uc007fxk.1 uc007fxk.2 uc007fxk.3 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus Belongs to the WD repeat PWP2 family. ribosomal small subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleus nucleolus small-subunit processome Pwp2p-containing subcomplex of 90S preribosome uc007fxk.1 uc007fxk.2 uc007fxk.3 
ENSMUST00000042561.14 Slc43a2 ENSMUST00000042561.14 solute carrier family 43, member 2, transcript variant 3 (from RefSeq NM_173388.2) ENSMUST00000042561.1 ENSMUST00000042561.10 ENSMUST00000042561.11 ENSMUST00000042561.12 ENSMUST00000042561.13 ENSMUST00000042561.2 ENSMUST00000042561.3 ENSMUST00000042561.4 ENSMUST00000042561.5 ENSMUST00000042561.6 ENSMUST00000042561.7 ENSMUST00000042561.8 ENSMUST00000042561.9 LAT4_MOUSE Lat4 NM_173388 Q5CD76 Q8CGA3 Slc43a2 uc007kec.1 uc007kec.2 uc007kec.3 uc007kec.4 Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine (PubMed:25480797, PubMed:15659399). Transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent (PubMed:25480797). Reaction=L-phenylalanine(in) = L-phenylalanine(out); Xref=Rhea:RHEA:27950, ChEBI:CHEBI:58095; Evidence=; Reaction=L-leucine(in) = L-leucine(out); Xref=Rhea:RHEA:73011, ChEBI:CHEBI:57427; Evidence=; Reaction=L-isoleucine(in) = L-isoleucine(out); Xref=Rhea:RHEA:70943, ChEBI:CHEBI:58045; Evidence=; Reaction=L-methionine(in) = L-methionine(out); Xref=Rhea:RHEA:70939, ChEBI:CHEBI:57844; Evidence=; Affinity and transport activity are regulated by a phosphorylation switch state at Ser-274 and Ser-297; increasing of affinity and amino acid transport activity via dephosphorylation at Ser-274 and phosphorylation at Ser-297. Cell membrane ; Multi-pass membrane protein Basolateral cell membrane Note=Located at the basolateral membrane in the small intestine enterocytes, kidney proximal tubule, thick ascending limb and, to a minor extent, of distal convoluted tubule epithelial cells. Expressed in intestine, kidney, brain and adipose tissue, heart and testis (PubMed:15659399). In the kidney, is detected in epithelial cells of the distal tubule and collecting duct (PubMed:15659399). In the intestine, is expressed mainly in crypt cells of the intestinal microvilli and epithelial cells in the base of the villus (PubMed:15659399). Expressed in small intestine enterocytes, the kidney proximal tubule, thick ascending limb and, to a minor extent, of distal convoluted tubule epithelial cells (PubMed:25480797). Regulated by protein diet. Glycosylated. Dephosphorylation at Ser-274 and phosphorylation at Ser-297 increase affinity and amino acid transport activity (PubMed:30379325). Phosphorylation-dephosphorylation cycle is regulated by food-entrained diurnal rhythm and dietary proteins (PubMed:32470053). Homozygous knockout fetuses mice for SLC43A2 display a reduced intrauterine growth not leading to a prenatal lethality. In addition, fetuses mice show a marked reduction in the concentration of almost all amino acids in the amniotic fluid (PubMed:25480797). Pups show growth defect, metabolic alterations and early postnatal lethality (PubMed:25480797). Belongs to the SLC43A transporter (TC 2.A.1.44) family. plasma membrane integral component of plasma membrane neutral amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity neutral amino acid transport L-amino acid transport membrane integral component of membrane transmembrane transport L-alpha-amino acid transmembrane transport uc007kec.1 uc007kec.2 uc007kec.3 uc007kec.4 
ENSMUST00000042575.7 Topors ENSMUST00000042575.7 topoisomerase I binding, arginine/serine-rich, transcript variant 1 (from RefSeq NM_134097.3) ENSMUST00000042575.1 ENSMUST00000042575.2 ENSMUST00000042575.3 ENSMUST00000042575.4 ENSMUST00000042575.5 ENSMUST00000042575.6 NM_134097 Q3U5B5 Q3UPZ1 Q3USN3 Q3UZ55 Q80Z37 Q8BXP2 Q8CFF5 Q8CGC8 Q920L3 TOPRS_MOUSE uc008shi.1 uc008shi.2 uc008shi.3 Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Interacts with TOP1. Interacts with the SUMO1 conjugating enzyme UBE2I. Interacts with SUMO1. Interacts with NKX3-1; polyubiquitinates NKX3-1 and induces its proteasomal degradation. Interacts with SIN3A; sumoylates SIN3A. Interacts with IKBKE; induced by DNA damage (By similarity). Interacts with p53/TP53. Interacts with PARK7/DJ-1. Nucleus cleus, PML body Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage. By genotoxic agents such as cisplatin and camptothecin. Phosphorylation at Ser-99 regulates the E3 ubiquitin-protein ligase activity but not the SUMO1-protein ligase activity. Phosphorylation at Ser-718 increases the E3 ubiquitin-protein ligase activity versus the E3 SUMO1-protein ligase activity resulting in increased p53/TP53 ubiquitination and degradation. Sumoylated. Sequence=AAH37141.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; ubiquitin ligase complex protein polyubiquitination spindle pole gamma-tubulin complex DNA binding antigen binding ubiquitin-protein transferase activity protein binding nucleus nucleoplasm centriole ubiquitin-dependent protein catabolic process protein monoubiquitination cellular response to DNA damage stimulus intrinsic apoptotic signaling pathway in response to DNA damage PML body nuclear speck transferase activity protein sumoylation SUMO transferase activity photoreceptor connecting cilium protein localization to nucleus ciliary basal body regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator proteasome-mediated ubiquitin-dependent protein catabolic process DNA topoisomerase binding positive regulation of transcription, DNA-templated metal ion binding positive regulation of ubiquitin-protein transferase activity maintenance of protein location in nucleus ubiquitin protein ligase activity protein K48-linked ubiquitination uc008shi.1 uc008shi.2 uc008shi.3 
ENSMUST00000042581.4 6430571L13Rik ENSMUST00000042581.4 RIKEN cDNA 6430571L13 gene (from RefSeq NM_175486.3) CC018_MOUSE ENSMUST00000042581.1 ENSMUST00000042581.2 ENSMUST00000042581.3 NM_175486 Q8BGK9 Q8BUH0 uc009rlg.1 uc009rlg.2 uc009rlg.3 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009rlg.1 uc009rlg.2 uc009rlg.3 
ENSMUST00000042586.10 Tespa1 ENSMUST00000042586.10 thymocyte expressed, positive selection associated 1 (from RefSeq NM_183264.4) ENSMUST00000042586.1 ENSMUST00000042586.2 ENSMUST00000042586.3 ENSMUST00000042586.4 ENSMUST00000042586.5 ENSMUST00000042586.6 ENSMUST00000042586.7 ENSMUST00000042586.8 ENSMUST00000042586.9 NM_183264 Q3TR68 Q3U132 Q8CEN9 TESP1_MOUSE uc007hrj.1 uc007hrj.2 uc007hrj.3 uc007hrj.4 uc007hrj.5 May play a role in the regulation of inositol 1,4,5- trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment (By similarity). Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. Interacts with PLCG1 and GRB2; the association is increased with prolonged stimulation of the TCR and may facilitate the assembly of the LAT signalosome (By similarity). Interacts with ITPR1 and ITPR3. Interacts with HSPA9 (By similarity). Cytoplasm Endoplasmic reticulum membrane Note=May localize to mitochondria-associated endoplasmic reticulum membrane (MAM). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U132-1; Sequence=Displayed; Name=2; IsoId=Q3U132-2; Sequence=VSP_030491, VSP_030492; Name=3; IsoId=Q3U132-3; Sequence=VSP_030490; Expressed in lymphoid tissues, with highest expression levels detected in thymus and lower levels in spleen and lymph nodes (at protein level). Detected in CD4(+) and CD8(+) T-cells, B-cells and mast cells. Not detected in monocytes/macrophages. Present in fetal thymus at 14.5 dpc. Expressed during thymocyte maturation, the expression being highest in CD4(+)CD8(+) thymocytes and decreasing with maturation. May be phosphorylated in response to store-operated Ca(+2) entry. Mutant mice display defective T-cell development, resulting in notably fewer mature CD4(+) and CD8(+) cells in the thymus. The architecture of the thymus is altered, as characterized by smaller areas of the medulla. Mice also have fewer peripheral T-cells in spleen and display diminished T-cell antigen receptor (TCR)-mediated responses. Sequence=AAH64065.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC25532.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function receptor binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane COP9 signalosome COP9 signalosome assembly membrane positive regulation of T cell differentiation in thymus positive regulation of T cell receptor signaling pathway uc007hrj.1 uc007hrj.2 uc007hrj.3 uc007hrj.4 uc007hrj.5 
ENSMUST00000042594.13 Mlc1 ENSMUST00000042594.13 megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human), transcript variant 1 (from RefSeq NM_133241.2) ENSMUST00000042594.1 ENSMUST00000042594.10 ENSMUST00000042594.11 ENSMUST00000042594.12 ENSMUST00000042594.2 ENSMUST00000042594.3 ENSMUST00000042594.4 ENSMUST00000042594.5 ENSMUST00000042594.6 ENSMUST00000042594.7 ENSMUST00000042594.8 ENSMUST00000042594.9 MLC1_MOUSE NM_133241 Q8VHK5 uc007xev.1 uc007xev.2 uc007xev.3 Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. Interacts with ATP1B1. Part of a complex containing ATP1B1, TRPV4, AQP4 and HEPACAM. Membrane ; Multi-pass membrane protein Cell membrane Cytoplasm, perinuclear region Endoplasmic reticulum protein binding cytoplasm lysosome endosome early endosome endoplasmic reticulum plasma membrane caveola cell-cell junction ion transport protein transport membrane integral component of membrane vesicle-mediated transport basolateral plasma membrane apical plasma membrane cytoplasmic vesicle positive regulation of intracellular transport ion transmembrane transport macromolecular complex binding membrane raft regulation of response to osmotic stress perinuclear region of cytoplasm protein oligomerization recycling endosome cellular response to cholesterol caveolin-mediated endocytosis ion channel activity uc007xev.1 uc007xev.2 uc007xev.3 
ENSMUST00000042601.9 Dhx38 ENSMUST00000042601.9 DEAH-box helicase 38, transcript variant 2 (from RefSeq NR_151644.1) Dhx38 ENSMUST00000042601.1 ENSMUST00000042601.2 ENSMUST00000042601.3 ENSMUST00000042601.4 ENSMUST00000042601.5 ENSMUST00000042601.6 ENSMUST00000042601.7 ENSMUST00000042601.8 NR_151644 Q80X98 Q80X98_MOUSE uc009nij.1 uc009nij.2 uc009nij.3 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily. nucleotide binding mRNA splicing, via spliceosome nucleic acid binding RNA binding helicase activity ATP binding hydrolase activity catalytic step 2 spliceosome uc009nij.1 uc009nij.2 uc009nij.3 
ENSMUST00000042603.14 Inhba ENSMUST00000042603.14 inhibin beta-A (from RefSeq NM_008380.2) ENSMUST00000042603.1 ENSMUST00000042603.10 ENSMUST00000042603.11 ENSMUST00000042603.12 ENSMUST00000042603.13 ENSMUST00000042603.2 ENSMUST00000042603.3 ENSMUST00000042603.4 ENSMUST00000042603.5 ENSMUST00000042603.6 ENSMUST00000042603.7 ENSMUST00000042603.8 ENSMUST00000042603.9 Inhba NM_008380 Q3UY39 Q3UY39_MOUSE uc057kpo.1 uc057kpo.2 uc057kpo.3 This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Homozygous knockout mice for this gene lack whiskers and exhibit tooth and palate defects, leading to neonatal lethality. [provided by RefSeq, Aug 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK134991.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Secreted Belongs to the TGF-beta family. G1/S transition of mitotic cell cycle ovarian follicle development hair follicle development hematopoietic progenitor cell differentiation cytokine activity hormone activity extracellular region extracellular space regulation of transcription from RNA polymerase II promoter cell cycle arrest growth factor activity negative regulation of cell proliferation male gonad development positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation peptide hormone binding striatal medium spiny neuron differentiation negative regulation of cell growth positive regulation of cellular protein metabolic process activin receptor signaling pathway inhibin binding endodermal cell differentiation odontogenesis response to drug hemoglobin biosynthetic process progesterone secretion identical protein binding activin A complex inhibin A complex positive regulation of erythrocyte differentiation negative regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of follicle-stimulating hormone secretion protein heterodimerization activity negative regulation of hair follicle development palate development type II activin receptor binding cellular response to follicle-stimulating hormone stimulus cellular response to cholesterol GABAergic neuron differentiation extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway in absence of ligand uc057kpo.1 uc057kpo.2 uc057kpo.3 
ENSMUST00000042608.8 Acd ENSMUST00000042608.8 adrenocortical dysplasia, transcript variant 2 (from RefSeq NM_001348349.2) ACD_MOUSE Acd ENSMUST00000042608.1 ENSMUST00000042608.2 ENSMUST00000042608.3 ENSMUST00000042608.4 ENSMUST00000042608.5 ENSMUST00000042608.6 ENSMUST00000042608.7 NM_001348349 Q3TBB1 Q3TUR7 Q3UKL6 Q3V3Y1 Q5EE38 Q99KF8 uc009ndq.1 uc009ndq.2 uc009ndq.3 Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity (By similarity). May play a role in organogenesis (PubMed:15537664). Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers with POT1. Identified in a complex with POT1 and single-stranded telomeric DNA. Interacts with STN1 and TINF2. Q5EE38; Q8K2X3: Stn1; NbExp=2; IntAct=EBI-6258642, EBI-2553883; Q5EE38-1; Q91WC1: Pot1; NbExp=2; IntAct=EBI-15647355, EBI-7051001; Q5EE38-1; Q3TNS5: Pot1b; NbExp=2; IntAct=EBI-15647355, EBI-15647404; Nucleus Chromosome, telomere Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q5EE38-1; Sequence=Displayed; Name=2; IsoId=Q5EE38-2; Sequence=VSP_019070, VSP_019071; Name=3; IsoId=Q5EE38-3; Sequence=VSP_019068, VSP_019073; Name=4; IsoId=Q5EE38-4; Sequence=VSP_019067; Name=5; IsoId=Q5EE38-5; Sequence=VSP_019069, VSP_019072, VSP_019074, VSP_019075; Ubiquitous. Expressed from 7 dpc to 18 dpc throughout development. Note=Defects in Acd are the cause of adrenocortical dysplasia (ACD). ACD is a spontaneous autosomal recessive mouse mutant resulting from spontaneous splicing mutation of acd. ACD mice are characterized by developmental defects in organs derived from the urogenital ridge, reduced survival, poor growth, skin hyperpigmentation and adrenal insufficiency. Forty percent of the mutants died within 24 hours. Analysis of 14.5 dpc to 17.5 dpc embryos revealed reduced formation of caudal structure as well as limb defects. Adrenocortical dysplasia mouse was initially reported as a model of human congenital adrenal hypoplasia (AHC). telomere maintenance chromosome, telomeric region nuclear telomere cap complex nuclear chromosome, telomeric region skeletal system development urogenital system development DNA binding protein binding nucleus nucleoplasm chromosome intracellular protein transport telomere capping nuclear body embryonic limb morphogenesis protection from non-homologous end joining at telomere telomere assembly negative regulation of telomere maintenance via telomerase positive regulation of telomere maintenance via telomerase segmentation telomeric DNA binding macromolecular complex binding positive regulation of telomerase activity positive regulation of single-stranded telomeric DNA binding DNA polymerase binding telosome protein localization to chromosome, telomeric region establishment of protein localization to telomere uc009ndq.1 uc009ndq.2 uc009ndq.3 
ENSMUST00000042614.13 Hectd4 ENSMUST00000042614.13 HECT domain E3 ubiquitin protein ligase 4 (from RefSeq NM_181421.5) E9Q2E4 E9Q2E4_MOUSE ENSMUST00000042614.1 ENSMUST00000042614.10 ENSMUST00000042614.11 ENSMUST00000042614.12 ENSMUST00000042614.2 ENSMUST00000042614.3 ENSMUST00000042614.4 ENSMUST00000042614.5 ENSMUST00000042614.6 ENSMUST00000042614.7 ENSMUST00000042614.8 ENSMUST00000042614.9 Hectd4 NM_181421 uc008ziv.1 uc008ziv.2 uc008ziv.3 ubiquitin-protein transferase activity glucose metabolic process protein ubiquitination transferase activity glucose homeostasis uc008ziv.1 uc008ziv.2 uc008ziv.3 
ENSMUST00000042617.14 Clcnka ENSMUST00000042617.14 chloride channel, voltage-sensitive Ka, transcript variant 1 (from RefSeq NM_024412.3) A2ADB3 CLCKA_MOUSE Clcnk1 ENSMUST00000042617.1 ENSMUST00000042617.10 ENSMUST00000042617.11 ENSMUST00000042617.12 ENSMUST00000042617.13 ENSMUST00000042617.2 ENSMUST00000042617.3 ENSMUST00000042617.4 ENSMUST00000042617.5 ENSMUST00000042617.6 ENSMUST00000042617.7 ENSMUST00000042617.8 ENSMUST00000042617.9 NM_024412 Q6UB69 Q8JZU7 Q9WUB7 uc008vof.1 uc008vof.2 uc008vof.3 uc008vof.4 This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 4. This gene is syntenic with human CLCNKB (geneID:1188). Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Sep 2009]. Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. May be the basolateral chloride channel mediating net chloride absorption in CTAL cells. Homodimer (By similarity). Interacts with BSND. Forms heteromers with BSND in the thin ascending limb of Henle. Membrane ; Multi- pass membrane protein Specifically expressed in the kidney. All nephron segments expressing BSND also express CLCNK proreins. Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. voltage-gated ion channel activity voltage-gated chloride channel activity chloride channel activity protein binding endoplasmic reticulum integral component of plasma membrane ion transport chloride transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane ion transmembrane transport chloride channel complex regulation of ion transmembrane transport metal ion binding regulation of body fluid levels transmembrane transport renal inner medulla development chloride transmembrane transport uc008vof.1 uc008vof.2 uc008vof.3 uc008vof.4 
ENSMUST00000042646.8 Atoh8 ENSMUST00000042646.8 atonal bHLH transcription factor 8 (from RefSeq NM_153778.3) ATOH8_MOUSE Ath6 Atoh8 ENSMUST00000042646.1 ENSMUST00000042646.2 ENSMUST00000042646.3 ENSMUST00000042646.4 ENSMUST00000042646.5 ENSMUST00000042646.6 ENSMUST00000042646.7 NM_153778 Q8C1I7 Q99NA2 uc009cic.1 uc009cic.2 uc009cic.3 Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). Regulates endothelial cell proliferation, migration and tube-like structures formation (By similarity). Modulates endothelial cell differentiation through NOS3 (By similarity). May be implicated in specification and differentiation of neuronal cell lineages in the brain (PubMed:11733035). May participate in kidney development and may be involved in podocyte differentiation (PubMed:16937370). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (PubMed:18560595). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (PubMed:24186058). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (By similarity). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (PubMed:23938248). Efficient DNA binding requires dimerization with another bHLH protein. Interacts with NEUROG3 and NEUROD1. Interacts with ZFPM2; mediates indirect interaction with GATA4. Forms a heterodimer with TCF3; repress transcription of TCF3 and TCF3/NEUROG3 dimer-induced transactivation of E box-dependent promoters. Nucleus Nucleus speckle Cytoplasm Expressed by subsets of mature neurons (PubMed:11733035). Expressed in kidney (podocytes) (PubMed:16937370). Expression is restricted to the atria, lung mesenchyme, and vascular smooth muscle (PubMed:23836893). Expressed at high levels at 8.5 dpc and its expression level gradually decreases during embryogenesis. At 12.5 dpc, is expressed throughout the developing nervous system. It is expressed in both the ventricular zone and the mantle layer of the developing brain. At 14.5 dpc, expressed in the cortical plate as well as in other regions of the brain. Also expressed at a high level in the spinal cord and dorsal root ganglia. Expressed by almost all cells in the spinal cord and dorsal root ganglia at this stage. At later stages, expression is gradually restricted to several regions such as the hippocampus, cerebellum and retina. In the hippocampus, a high level of expression continues during embryogenesis until adulthood. Expressed in the CA1- CA3 regions and the dentate gyrus. At 18.5 dpc, expressed in cerebellum by Purkinje cells and granule cell precursors in the external granular layer (EGL). By postnatal day 4, expressed by aligned Purkinje cells and by the EGL and internal granular layer (IGL) cells. In the adult cerebellum, expressed at a high level by Purkinje cells and weakly by granule cells in the IGL. In developing retina, expressed in both the ganglion cell layer and the ventricular zone at 11.5 dpc and 17.5 dpc. Expression becomes very weak in the adult retina. Early in metanephric development, expressed in metanephric mesenchyme but not ureteric bud- derived cells, with overall expression being most abundant in the nephrogenic zone. From 14.5 dpc to birth, expressed at constant levels. By day 13, corresponding to the end of new nephron induction, expression levels begin to decline. By day 19, expression returned to fetal levels, and by day 40, the low level of expression that persisted into adulthood is established. In adult kidney, expression is restricted to podocytes. Expressed in pancreatic tissue from 12.5 dpc until 17.5 dpc. Is still detectable at low level,at postnatal day 1 and in isolated pancreatic islets in adult (PubMed:18560595). Specifically activated by bHLH factors. The bHLH domain mediates transcriptional repression by inhibiting TCF3 transcriptional activity through heterodimerization. Mice heterozygous survive to adulthood and present no phenotype (PubMed:18560595). The homozygous knockout of Atoh8 is embryonic lethal (PubMed:18560595). Contains a degenerate basic motif not likely to bind DNA. formation of primary germ layer negative regulation of endothelial cell proliferation DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated multicellular organism development nervous system development transcription factor binding positive regulation of endothelial cell migration negative regulation of gene expression nuclear speck cell differentiation activating transcription factor binding tube formation positive regulation of endothelial cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated protein dimerization activity myoblast proliferation SMAD protein signal transduction E-box binding positive regulation of pri-miRNA transcription from RNA polymerase II promoter uc009cic.1 uc009cic.2 uc009cic.3 
ENSMUST00000042647.7 Plekhg6 ENSMUST00000042647.7 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 (from RefSeq NM_198604.2) E9QJZ0 ENSMUST00000042647.1 ENSMUST00000042647.2 ENSMUST00000042647.3 ENSMUST00000042647.4 ENSMUST00000042647.5 ENSMUST00000042647.6 NM_198604 PKHG6_MOUSE Q8R0J1 uc009dum.1 uc009dum.2 uc009dum.3 Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis (By similarity). Interacts with MYH10. Interacts with ELMO1 and EZR (in an open conformation). Interacts with CSPP1 (By similarity). Cell projection, microvillus Cytoplasm, cytoskeleton, spindle Cleavage furrow Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR where it participates in macropinocytosis. Rho guanyl-nucleotide exchange factor activity GTPase activator activity cytoplasm centrosome spindle cytoskeleton microvillus biological_process cell junction cleavage furrow regulation of Rho protein signal transduction cell projection positive regulation of GTPase activity uc009dum.1 uc009dum.2 uc009dum.3 
ENSMUST00000042658.5 Echdc3 ENSMUST00000042658.5 enoyl Coenzyme A hydratase domain containing 3 (from RefSeq NM_024208.4) ECHD3_MOUSE ENSMUST00000042658.1 ENSMUST00000042658.2 ENSMUST00000042658.3 ENSMUST00000042658.4 Echdc3 NM_024208 Q99LV0 Q9D7J9 uc008igi.1 uc008igi.2 uc008igi.3 May play a role in fatty acid biosynthesis and insulin sensitivity. Mitochondrion Belongs to the enoyl-CoA hydratase/isomerase family. molecular_function catalytic activity mitochondrion biological_process uc008igi.1 uc008igi.2 uc008igi.3 
ENSMUST00000042661.8 Ttyh3 ENSMUST00000042661.8 tweety family member 3, transcript variant 2 (from RefSeq NM_175274.5) ENSMUST00000042661.1 ENSMUST00000042661.2 ENSMUST00000042661.3 ENSMUST00000042661.4 ENSMUST00000042661.5 ENSMUST00000042661.6 ENSMUST00000042661.7 Kiaa1691 NM_175274 Q69ZD3 Q6P5F7 Q6PCX0 Q8C789 TTYH3_MOUSE uc009ahw.1 uc009ahw.2 uc009ahw.3 uc009ahw.4 uc009ahw.5 Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction (By similarity). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P5F7-1; Sequence=Displayed; Name=2; IsoId=Q6P5F7-2; Sequence=VSP_029771, VSP_029772; Expressed in excitable tissues. Expressed in the brain, heart, skeletal muscle, colon, spleen, kidney and peripheral blood leukocytes. Also expressed in fat, the pancreas, thymus, and uterus. N-glycosylated. Belongs to the tweety family. Sequence=AAH59083.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; intracellular calcium activated chloride channel activity chloride channel activity plasma membrane ion transport chloride transport membrane integral component of membrane ion transmembrane transport chloride channel complex volume-sensitive chloride channel activity chloride transmembrane transport uc009ahw.1 uc009ahw.2 uc009ahw.3 uc009ahw.4 uc009ahw.5 
ENSMUST00000042662.10 Mzt1 ENSMUST00000042662.10 mitotic spindle organizing protein 1 (from RefSeq NM_175245.4) ENSMUST00000042662.1 ENSMUST00000042662.2 ENSMUST00000042662.3 ENSMUST00000042662.4 ENSMUST00000042662.5 ENSMUST00000042662.6 ENSMUST00000042662.7 ENSMUST00000042662.8 ENSMUST00000042662.9 MZT1_MOUSE Mozart1 NM_175245 Q8BUR9 uc007uuu.1 uc007uuu.2 uc007uuu.3 uc007uuu.4 Required for gamma-tubulin complex recruitment to the centrosome. Part of the gamma-tubulin complex. Interacts with TUBG1. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Belongs to the MOZART1 family. cytoplasm centrosome microtubule organizing center spindle cytoskeleton gamma-tubulin ring complex interphase microtubule organizing center gamma-tubulin complex localization interphase microtubule nucleation by interphase microtubule organizing center mitotic spindle assembly uc007uuu.1 uc007uuu.2 uc007uuu.3 uc007uuu.4 
ENSMUST00000042664.10 Slc16a2 ENSMUST00000042664.10 solute carrier family 16 (monocarboxylic acid transporters), member 2 (from RefSeq NM_009197.2) ENSMUST00000042664.1 ENSMUST00000042664.2 ENSMUST00000042664.3 ENSMUST00000042664.4 ENSMUST00000042664.5 ENSMUST00000042664.6 ENSMUST00000042664.7 ENSMUST00000042664.8 ENSMUST00000042664.9 NM_009197 Q05BA2 Q05BA2_MOUSE Slc16a2 slc16a2 uc009tzy.1 uc009tzy.2 uc009tzy.3 Membrane ; Multi- pass membrane protein plasma membrane integral component of plasma membrane thyroid hormone transmembrane transporter activity membrane integral component of membrane transmembrane transport thyroid hormone transport uc009tzy.1 uc009tzy.2 uc009tzy.3 
ENSMUST00000042665.9 Parp14 ENSMUST00000042665.9 poly (ADP-ribose) polymerase family, member 14 (from RefSeq NM_001039530.3) E9QP48 ENSMUST00000042665.1 ENSMUST00000042665.2 ENSMUST00000042665.3 ENSMUST00000042665.4 ENSMUST00000042665.5 ENSMUST00000042665.6 ENSMUST00000042665.7 ENSMUST00000042665.8 Kiaa1268 NM_001039530 PAR14_MOUSE Parp14 Q2EMV9 Q571C6 Q8BN35 Q8VDT6 uc007zbs.1 uc007zbs.2 uc007zbs.3 uc007zbs.4 ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:27796300). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Catalyzes mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6- dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (By similarity). Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58225; Evidence=; Interacts with STAT6 (PubMed:16537510). Interacts with PARP10 (By similarity). Interacts with PARP9 in IFNG-stimulated macrophages; the interaction prevents PARP14-mediated STAT1 and STAT6 ADP- riboslylation (By similarity). Q2EMV9; P06745: Gpi; NbExp=4; IntAct=EBI-1534943, EBI-1534927; Q2EMV9; P52633: Stat6; NbExp=3; IntAct=EBI-1534943, EBI-647085; Nucleus Cytoplasm Note=In steady state cells the protein is mostly nuclear (PubMed:16537510). A minor proportion is detected in the cytoplasm (PubMed:16537510). In macrophages, mainly localizes to the cytoplasm (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2EMV9-1; Sequence=Displayed; Name=2; IsoId=Q2EMV9-2; Sequence=VSP_020020; Weakly expressed in the thymus during development and in adulthood (PubMed:18069692). Expressed in macrophages (PubMed:27796300). Up-regulated by IFNG in macrophages. Down-regulated by IL4 in macrophages. Auto-ADP-ribosylated. Belongs to the ARTD/PARP family. The role of PARP14-mediated ADP-ribosylation of STAT1 in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703'. Sequence=AAH21340.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH21340.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; immune system process NAD+ ADP-ribosyltransferase activity protein binding nucleus cytoplasm cytosol protein ADP-ribosylation negative regulation of gene expression transferase activity transferase activity, transferring glycosyl groups enzyme binding positive regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein innate immune response negative regulation of interferon-gamma-mediated signaling pathway protein poly-ADP-ribosylation NAD+ binding positive regulation of interleukin-4-mediated signaling pathway protein ADP-ribosylase activity uc007zbs.1 uc007zbs.2 uc007zbs.3 uc007zbs.4 
ENSMUST00000042666.13 Slc39a5 ENSMUST00000042666.13 solute carrier family 39 (metal ion transporter), member 5, transcript variant 3 (from RefSeq NM_001136237.1) ENSMUST00000042666.1 ENSMUST00000042666.10 ENSMUST00000042666.11 ENSMUST00000042666.12 ENSMUST00000042666.2 ENSMUST00000042666.3 ENSMUST00000042666.4 ENSMUST00000042666.5 ENSMUST00000042666.6 ENSMUST00000042666.7 ENSMUST00000042666.8 ENSMUST00000042666.9 NM_001136237 Q9D856 Q9D909 S39A5_MOUSE Slc39a5 Zip5 uc007hmp.1 uc007hmp.2 uc007hmp.3 uc007hmp.4 uc007hmp.5 Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine by the uptake of zinc from the blood into the intestine (PubMed:15322118, PubMed:24303081). The transport mechanism is temperature- and concentration-dependent and saturable (PubMed:15322118). In addition, is also a high affinity copper transporter in vitro (By similarity). Also may regulate glucose- stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis (PubMed:30324491). Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (By similarity). Plays a role in eye development (By similarity). Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence= Kinetic parameters: KM=1.7 uM for Zn(2+) (in HEK293 cells transfected) ; KM=2.1 uM for Zn(2+) (in the endogenous system in HEK293 cells) ; Vmax=13.2 pmol/min/mg protein towards Zn(2+) (in HEK293 cells transfected) ; Vmax=4.1 pmol/min/mg protein towards Zn(2+) (in the endogenous system in HEK293 cells) ; Homodimer. Basolateral cell membrane ulti-pass membrane protein Note=Localized to the basolateral surfaces of enterocytes, pancreatic acinar and endoderm cells (PubMed:15358787). During zinc deficiency diet, the basolateral cell membrane localization is lost in the intestine, the visceral yolk sac and acinar cell (PubMed:15358787). During zinc repletion, is relocalized to the basolateral membrane of enterocytes, visceral endoderm cells and pancreatic acinar cells (PubMed:18020946). Zinc can regulate the turnover of protein at the membrane (PubMed:18020946). During zinc deficiency, is internalized and degraded in enterocytes, acinar cells and endoderm cells (PubMed:18020946). Endocytosed through the endolysosomal degradation pathway RAB5A pathway (PubMed:24039764). Expressed in all stages of eye development and primarily in the sclera and several layers of the retina, including the inner segment, outer plexiform layer and ganglion cell layer (PubMed:24891338). Expressed in pancreas, kidney and the proximal and distal small intestine as well as in the embryonic visceral yolk sac (PubMed:15358787). In the proximal intestine, expression is predominant in the crypts but diminishes toward the apical regions of the villi (PubMed:15358787). Expressed at 10 dpc, postnatal day P0, P13 and adult. Induced in a zinc-responsive manner (PubMed:18020946). During zinc deficiency, the transcript remains associated with polysomes and is rapidly resynthesized and targeted to the basolateral membranes of these cell types after zinc-repletion (PubMed:18020946). N-Glycosylated. Methylated at His-371 by METTL9. Homozygous knockout mice lacking Slc39a5 display normal fecondity and seem normal. Belongs to the ZIP transporter (TC 2.A.5) family. eye development zinc ion transmembrane transporter activity plasma membrane integral component of plasma membrane ion transport zinc II ion transport cellular zinc ion homeostasis membrane integral component of membrane basolateral plasma membrane metal ion transport BMP signaling pathway cellular response to zinc ion starvation metal ion transmembrane transporter activity positive regulation of mRNA splicing, via spliceosome transmembrane transport zinc II ion transmembrane import uc007hmp.1 uc007hmp.2 uc007hmp.3 uc007hmp.4 uc007hmp.5 
ENSMUST00000042676.6 Or56a41 ENSMUST00000042676.6 Membrane ; Multi- pass membrane protein (from UniProt A0A2I3BS13) A0A2I3BS13 A0A2I3BS13_MOUSE ENSMUST00000042676.1 ENSMUST00000042676.2 ENSMUST00000042676.3 ENSMUST00000042676.4 ENSMUST00000042676.5 Olfr680 Or56a41 uc291twl.1 uc291twl.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291twl.1 uc291twl.2 
ENSMUST00000042699.14 Aldh8a1 ENSMUST00000042699.14 aldehyde dehydrogenase 8 family, member A1 (from RefSeq NM_178713.4) AL8A1_MOUSE ENSMUST00000042699.1 ENSMUST00000042699.10 ENSMUST00000042699.11 ENSMUST00000042699.12 ENSMUST00000042699.13 ENSMUST00000042699.2 ENSMUST00000042699.3 ENSMUST00000042699.4 ENSMUST00000042699.5 ENSMUST00000042699.6 ENSMUST00000042699.7 ENSMUST00000042699.8 ENSMUST00000042699.9 NM_178713 Q8BH00 Q91WS6 Raldh4 uc007eoq.1 uc007eoq.2 uc007eoq.3 Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. Reaction=2-aminomuconate 6-semialdehyde + H2O + NAD(+) = (2Z,4E)-2- aminomuconate + 2 H(+) + NADH; Xref=Rhea:RHEA:14469, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:77634, ChEBI:CHEBI:77859; EC=1.2.1.32; Evidence=; Kinetic parameters: KM=2.3 uM for 9-cis-retinal ; Vmax=3.4 nmol/min/mg enzyme ; Note=Activity was measured with total soluble protein.; Amino-acid degradation; L-kynurenine degradation. Cytoplasm Detected in hepatocytes and in proximal and distal convoluted tubules in kidney cortex (at protein level). Highly expressed in adult liver and in kidney cortex. First detected in embryonic liver after 15 days of development. Belongs to the aldehyde dehydrogenase family. retinal dehydrogenase activity cytoplasm oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor retinoic acid metabolic process retinal metabolic process 9-cis-retinoic acid biosynthetic process aminomuconate-semialdehyde dehydrogenase activity oxidation-reduction process L-kynurenine catabolic process uc007eoq.1 uc007eoq.2 uc007eoq.3 
ENSMUST00000042700.12 Gstp2 ENSMUST00000042700.12 glutathione S-transferase, pi 2 (from RefSeq NM_181796.2) ENSMUST00000042700.1 ENSMUST00000042700.10 ENSMUST00000042700.11 ENSMUST00000042700.2 ENSMUST00000042700.3 ENSMUST00000042700.4 ENSMUST00000042700.5 ENSMUST00000042700.6 ENSMUST00000042700.7 ENSMUST00000042700.8 ENSMUST00000042700.9 GSTP2_MOUSE Gstpia NM_181796 P46425 Q505C3 uc008fyg.1 uc008fyg.2 uc008fyg.3 uc008fyg.4 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cannot metabolize 1-chloro-2,4-dinitrobenzene. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Homodimer. Selectively expressed in gall bladder, colon, heart, and skeletal muscle. Belongs to the GST superfamily. Pi family. glutathione transferase activity glutathione peroxidase activity nucleus cytoplasm mitochondrion cytosol plasma membrane glutathione metabolic process drug binding transferase activity protein kinase binding S-nitrosoglutathione binding dinitrosyl-iron complex binding glutathione binding TRAF2-GSTP1 complex cellular oxidant detoxification uc008fyg.1 uc008fyg.2 uc008fyg.3 uc008fyg.4 
ENSMUST00000042701.13 Mxd4 ENSMUST00000042701.13 Max dimerization protein 4 (from RefSeq NM_010753.3) ENSMUST00000042701.1 ENSMUST00000042701.10 ENSMUST00000042701.11 ENSMUST00000042701.12 ENSMUST00000042701.2 ENSMUST00000042701.3 ENSMUST00000042701.4 ENSMUST00000042701.5 ENSMUST00000042701.6 ENSMUST00000042701.7 ENSMUST00000042701.8 ENSMUST00000042701.9 Mxd4 NM_010753 Q91VN7 Q91VN7_MOUSE uc008xby.1 uc008xby.2 uc008xby.3 Nucleus protein dimerization activity uc008xby.1 uc008xby.2 uc008xby.3 
ENSMUST00000042702.7 Atpsckmt ENSMUST00000042702.7 ATP synthase C subunit lysine N-methyltransferase, transcript variant 1 (from RefSeq NM_026546.3) ACKMT_MOUSE Atpsckmt ENSMUST00000042702.1 ENSMUST00000042702.2 ENSMUST00000042702.3 ENSMUST00000042702.4 ENSMUST00000042702.5 ENSMUST00000042702.6 Fam173b NM_026546 Q8K2S1 Q9D1Z3 uc007vkk.1 uc007vkk.2 uc007vkk.3 Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090). Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54193; Evidence=; Mitochondrion membrane ; Single-pass membrane protein Note=Localizes to mitochondrial cristae. Ubiquitously expressed. Expression is up-regulated in dorsal root ganglia (DRG) during chronic inflammatory pain. Contains an atypical, non-cleavable mitochondrial targeting sequence responsible for its localization to mitochondria. Belongs to the ANT/ATPSC lysine N-methyltransferase family. mitochondrion methyltransferase activity membrane integral component of membrane protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine methylation peptidyl-lysine trimethylation mitochondrial crista mitochondrial membrane methylation positive regulation of sensory perception of pain positive regulation of proton-transporting ATP synthase activity, rotational mechanism regulation of mitochondrial ATP synthesis coupled proton transport uc007vkk.1 uc007vkk.2 uc007vkk.3 
ENSMUST00000042706.3 Nr0b2 ENSMUST00000042706.3 nuclear receptor subfamily 0, group B, member 2 (from RefSeq NM_011850.3) ENSMUST00000042706.1 ENSMUST00000042706.2 NM_011850 NR0B2_MOUSE Q53Z53 Q62227 Shp uc008vcz.1 uc008vcz.2 uc008vcz.3 uc008vcz.4 This gene encodes a member of the nuclear hormone receptor family of proteins. The encoded orphan receptor lacks a DNA binding domain but modulates gene expression by interacting with other hormone receptors to competitively inhibit binding of coactivators while also acting as a transcriptional corepressor. The encoded receptor may regulate bile acid synthesis and sexual maturation in males. Homozygous knockout mice exhibit accumulation of bile acids, reduced levels of low density lipoprotein cholesterol (LDL-C), and in male mice, earlier testicular maturation. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK004930.1, BC019540.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (PubMed:8650544). Specifically inhibits transactivation of the nuclear receptor with which it interacts (PubMed:8650544). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (By similarity). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2- mediated hepatic lipid metabolism (PubMed:25212631). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (PubMed:30555544). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (PubMed:30555544). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (By similarity). Interacts (via N-terminus) with NEUROD1 (via N-terminus and C-terminus) (By similarity). Interacts with ID2 (By similarity). Interacts with NR5A2, PPARA and PPARG (By similarity). Interacts with RARA, RXRA, THRB, NR5A1 and NR1I3 (PubMed:8650544). Interacts with EID1 (PubMed:11964378). Interacts with NR1D1 (PubMed:25212631, PubMed:30555544). Interacts with RORG (PubMed:25212631). Interacts with NFIL3 and BHLHE41 (PubMed:30555544). Interacts with HNF4A; the resulting heterodimer is transcriptionally inactive (By similarity). Interacts with DDX3X; this interaction disrupts the interaction between HNF4 and NR0B2/SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers (By similarity). Q62227; Q04207: Rela; NbExp=3; IntAct=EBI-4310440, EBI-644400; Q62227; Q923E4: Sirt1; NbExp=2; IntAct=EBI-4310440, EBI-1802585; Q62227; P70196: Traf6; NbExp=5; IntAct=EBI-4310440, EBI-448028; Cytoplasm Nucleus Note=Colocalizes with NEUROD1 in the nucleus. Expressed in islets of Langerhans (at protein level) (PubMed:14752053). Expressed in a circadian manner in the liver (PubMed:25212631). Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors. Mice exhibit a significant disruption in the circadian rhythm of several important hepatic genes involved in the metabolism of lipid, cholesterol, fatty acid and bile acid. Belongs to the nuclear hormone receptor family. NR0 subfamily. negative regulation of transcription from RNA polymerase II promoter DNA binding steroid hormone receptor activity transcription corepressor activity protein binding nucleus cytoplasm regulation of transcription, DNA-templated Notch signaling pathway circadian rhythm transcription factor binding response to glucose positive regulation of gene expression negative regulation of gene expression protein domain specific binding animal organ regeneration positive regulation of insulin secretion circadian regulation of gene expression macromolecular complex protein homodimerization activity retinoic acid receptor binding peroxisome proliferator activated receptor binding steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity macromolecular complex binding negative regulation of transcription, DNA-templated retinoid X receptor binding thyroid hormone receptor binding rhythmic process uc008vcz.1 uc008vcz.2 uc008vcz.3 uc008vcz.4 
ENSMUST00000042710.8 Smim3 ENSMUST00000042710.8 small integral membrane protein 3 (from RefSeq NM_134133.2) ENSMUST00000042710.1 ENSMUST00000042710.2 ENSMUST00000042710.3 ENSMUST00000042710.4 ENSMUST00000042710.5 ENSMUST00000042710.6 ENSMUST00000042710.7 NM_134133 Nid67 Q921E9 Q99PE5 SMIM3_MOUSE uc008fag.1 uc008fag.2 uc008fag.3 uc008fag.4 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc008fag.1 uc008fag.2 uc008fag.3 uc008fag.4 
ENSMUST00000042717.13 Trim39 ENSMUST00000042717.13 tripartite motif-containing 39, transcript variant 1 (from RefSeq NM_024468.2) E9QLN4 E9QLN4_MOUSE ENSMUST00000042717.1 ENSMUST00000042717.10 ENSMUST00000042717.11 ENSMUST00000042717.12 ENSMUST00000042717.2 ENSMUST00000042717.3 ENSMUST00000042717.4 ENSMUST00000042717.5 ENSMUST00000042717.6 ENSMUST00000042717.7 ENSMUST00000042717.8 ENSMUST00000042717.9 NM_024468 Trim39 uc008ckt.1 uc008ckt.2 uc008ckt.3 mitochondrion cytosol zinc ion binding identical protein binding metal ion binding negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of apoptotic signaling pathway uc008ckt.1 uc008ckt.2 uc008ckt.3 
ENSMUST00000042724.8 Usp38 ENSMUST00000042724.8 ubiquitin specific peptidase 38 (from RefSeq NM_027554.2) ENSMUST00000042724.1 ENSMUST00000042724.2 ENSMUST00000042724.3 ENSMUST00000042724.4 ENSMUST00000042724.5 ENSMUST00000042724.6 ENSMUST00000042724.7 NM_027554 Q8BW70 Q8BWL1 Q8BX03 UBP38_MOUSE uc009mjd.1 uc009mjd.2 uc009mjd.3 Deubiquitinating enzyme that plays a role in various cellular processes, including DNA repair, cell cycle regulation, and immune response (PubMed:27692986, PubMed:35238669). Plays a role in the inhibition of type I interferon signaling by mediating the 'Lys-33' to 'Lys-48' ubiquitination transition of TBK1 leading to its degradation. Cleaves the ubiquitin chain from the histone demethylase LSD1/KDM1A and prevents it from degradation by the 26S proteasome, thus maintaining LSD1 protein level in cells. Plays a role in the DNA damage response by regulating the deacetylase activity of HDAC1. Mechanistically, removes the 'Lys-63'-linked ubiquitin chain promoting the deacetylase activity of HDAC1 in response to DNA damage. Acts also as a specific deubiquitinase of histone deacetylase 3/HDAC3 and cleaves its 'Lys-63'- linked ubiquitin chains to lower its histone deacetylase activity. Regulates MYC levels and cell proliferation via antagonizing ubiquitin E3 ligase FBXW7 thereby preventing MYC 'Lys-48'-linked ubiquitination and degradation. Participates in antiviral response by removing both 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of Zika virus envelope protein E. Constitutively associated with IL-33R/IL1RL1, deconjugates its 'Lys-27'-linked polyubiquitination resulting in its autophagic degradation. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with isoform 1 of FBXW7; this interaction prevents FBXW7-mediated degradation of MYC. Cytoplasm Nucleus Note=In response to DNA damage, recruited to DNA damage sites in the nucleus. USP38-deletion mice produce higher levels of IFN- beta, TNF-alpha, and IL-6 than WT mice in response to viral infection (PubMed:27692986). They are also more susceptible to inflammatory damage and death and developed more serious pulmonary fibrosis after bleomycin treatment (PubMed:35238669). Belongs to the peptidase C19 family. cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity uc009mjd.1 uc009mjd.2 uc009mjd.3 
ENSMUST00000042726.14 Rbm42 ENSMUST00000042726.14 RNA binding motif protein 42 (from RefSeq NM_133693.2) ENSMUST00000042726.1 ENSMUST00000042726.10 ENSMUST00000042726.11 ENSMUST00000042726.12 ENSMUST00000042726.13 ENSMUST00000042726.2 ENSMUST00000042726.3 ENSMUST00000042726.4 ENSMUST00000042726.5 ENSMUST00000042726.6 ENSMUST00000042726.7 ENSMUST00000042726.8 ENSMUST00000042726.9 NM_133693 Q3UBE0 Q91V81 RBM42_MOUSE uc009gfn.1 uc009gfn.2 uc009gfn.3 uc009gfn.4 Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. Interacts with HNRNPK. Nucleus Cytoplasm Note=Upon stress response, localizes with HNRNPK in cytoplasmic aggregates of stalled translational preinitiation complexes called stress granules. Expressed in cell lines (at protein level). Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Belongs to the RRM RBM42 family. Sequence=AAH09148.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH11286.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH27372.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH57928.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleic acid binding RNA binding nucleus cytoplasm negative regulation of mRNA splicing, via spliceosome ribonucleoprotein complex uc009gfn.1 uc009gfn.2 uc009gfn.3 uc009gfn.4 
ENSMUST00000042732.6 Fbxo45 ENSMUST00000042732.6 F-box protein 45 (from RefSeq NM_173439.2) ENSMUST00000042732.1 ENSMUST00000042732.2 ENSMUST00000042732.3 ENSMUST00000042732.4 ENSMUST00000042732.5 FBSP1_MOUSE Fbxo45 NM_173439 Q5M7B1 Q8K3B1 uc007yyl.1 uc007yyl.2 uc007yyl.3 Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1. Functions in substrate recognition but plays also an important role in assembly of the complex (By similarity). Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (PubMed:32341084). Regulates neuron migration during brain development through interaction with N-cadherin/CDH2 after secretion via a non-classical mechanism (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. Polyubiquitinates NMNAT2, an adenylyltransferase that acts as an axon maintenance factor, and regulates its stability and degradation by the proteasome. Acts also by ubiquitinating FBXW7 during prolonged mitotic arrest and promotes FBXW7 proteasomal degradation. Induces subsequently an increase in mitotic slippage and prevents mitotic cell death. In response to influenza infection, mediates interferon-lambda receptor IFNLR1 polyubiquitination and degradation through the ubiquitin- proteasome system by docking with its intracellular receptor domain (By similarity). Protein modification; protein ubiquitination. Forms a complex with MYCBP2 and SKP1 (PubMed:19398581). Interacts with HEY1; leading to FBXO45 nuclear translocation. Interacts (via SPRY domain) with CDH2. Secreted Postsynaptic cell membrane Presynaptic cell membrane Nucleus Note=Secreted by a non-classical mechanism. Expressed speciffically in the central nervous system, including cerebellum, medulla oblongata, olfactory bulb, hippocampus, cortex and brain stem. Homozygous animals die soon after birth due to respiratory distress. Embryos show abnormal innervation of the diaphragm, impaired synapse formation at neuromuscular junctions, and aberrant development of axon fiber tracts in the brain. Belongs to the FBXO45/Fsn family. neuron migration protein binding plasma membrane ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus multicellular organism development nervous system development postsynaptic density membrane protein ubiquitination SCF ubiquitin ligase complex cerebral cortex radially oriented cell migration cerebral cortex tangential migration corticospinal tract morphogenesis anterior commissure morphogenesis cell junction presynaptic membrane proteasome-mediated ubiquitin-dependent protein catabolic process synapse postsynaptic membrane innervation synapse assembly involved in innervation presynapse glutamatergic synapse presynaptic cytosol postsynaptic cytosol uc007yyl.1 uc007yyl.2 uc007yyl.3 
ENSMUST00000042734.3 1700066M21Rik ENSMUST00000042734.3 RIKEN cDNA 1700066M21 gene (from RefSeq NM_028546.1) CB069_MOUSE E9QNR4 ENSMUST00000042734.1 ENSMUST00000042734.2 NM_028546 Q9D9H8 uc007bay.1 uc007bay.2 uc007bay.3 uc007bay.4 May play a role in the respiratory chain. Mitochondrion matrix Belongs to the C2orf69 family. Sequence=BAB24787.1; Type=Frameshift; Evidence=; molecular_function cellular_component extracellular region biological_process uc007bay.1 uc007bay.2 uc007bay.3 uc007bay.4 
ENSMUST00000042740.13 Abca13 ENSMUST00000042740.13 ATP-binding cassette, sub-family A member 13 (from RefSeq NM_178259.3) ABCAD_MOUSE Abca13 ENSMUST00000042740.1 ENSMUST00000042740.10 ENSMUST00000042740.11 ENSMUST00000042740.12 ENSMUST00000042740.2 ENSMUST00000042740.3 ENSMUST00000042740.4 ENSMUST00000042740.5 ENSMUST00000042740.6 ENSMUST00000042740.7 ENSMUST00000042740.8 ENSMUST00000042740.9 NM_178259 Q5SSE9 Q80T20 Q8BHZ2 Q8CB91 uc007iaa.1 uc007iaa.2 May mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons. Reaction=ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate; Xref=Rhea:RHEA:39051, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Cytoplasmic vesicle membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5SSE9-1; Sequence=Displayed; Name=2; IsoId=Q5SSE9-2; Sequence=VSP_021073, VSP_021074; Name=3; IsoId=Q5SSE9-3; Sequence=VSP_021071, VSP_021072; Ubiquitously expressed. May be primarily expressed in kidney. Homozygous knockout mice for Abca13 are born normally and seem to have normal appearance and life span but show sensorimotor gating deficits. Belongs to the ABC transporter superfamily. Sequence=AAO18684.1; Type=Erroneous initiation; Evidence=; nucleotide binding lipid transporter activity ATP binding lipid transport membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances intracellular membrane-bounded organelle transmembrane transport uc007iaa.1 uc007iaa.2 
ENSMUST00000042747.4 Npy6r ENSMUST00000042747.4 neuropeptide Y receptor Y6 (from RefSeq NM_010935.4) ENSMUST00000042747.1 ENSMUST00000042747.2 ENSMUST00000042747.3 NM_010935 NPY6R_MOUSE Npy5r Ppyr2 Q3ZAW3 Q61212 Y2b uc008euv.1 uc008euv.2 Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY = PYY >= NPY (2-36) = [Leu-31, Pro-34] NPY > NPY (13-36) > PP. The activity of this receptor is mediated by G proteins that inhibits adenylate cyclase activity. Cell membrane; Multi-pass membrane protein. Kidney and discrete regions of the hypothalamus including the suprachiasmatic nucleus, anterior hypothalamus, bed nucleus stria terminalis, and the ventromedial nucleus. Expressed in embryo at 7 dpc. Belongs to the G-protein coupled receptor 1 family. Was originally called NPY5-R. peptide YY receptor activity pancreatic polypeptide receptor activity G-protein coupled receptor activity neuropeptide Y receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway membrane integral component of membrane uc008euv.1 uc008euv.2 
ENSMUST00000042750.3 Pgap4 ENSMUST00000042750.3 post-GPI attachment to proteins GalNAc transferase 4, transcript variant 1 (from RefSeq NM_025944.4) ENSMUST00000042750.1 ENSMUST00000042750.2 NM_025944 PGAP4_MOUSE Pgap4 Q3TN50 Q91YV9 Q9CYX3 Tmem246 uc008svx.1 uc008svx.2 uc008svx.3 uc008svx.4 Golgi-resident glycosylphosphatidylinositol (GPI)-N- acetylgalactosamine transferase involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI- anchors proteins. Required for the initial step of GPI-GalNAc biosynthesis, transfers GalNAc to GPI in the Golgi after fatty acid remodeling by PGAP2. Golgi apparatus membrane ; Multi-pass membrane protein Contains three transmembrane domains, including a tandem transmembrane domain insertion into its glycosyltransferase-A fold. Transmembrane domain 1 functions as a signal for Golgi targeting. The conserved DXD motif is involved in enzyme activity. Belongs to the PGAP4 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008svx.1 uc008svx.2 uc008svx.3 uc008svx.4 
ENSMUST00000042753.14 Rbm48 ENSMUST00000042753.14 RNA binding motif protein 48, transcript variant 1 (from RefSeq NM_172991.5) ENSMUST00000042753.1 ENSMUST00000042753.10 ENSMUST00000042753.11 ENSMUST00000042753.12 ENSMUST00000042753.13 ENSMUST00000042753.2 ENSMUST00000042753.3 ENSMUST00000042753.4 ENSMUST00000042753.5 ENSMUST00000042753.6 ENSMUST00000042753.7 ENSMUST00000042753.8 ENSMUST00000042753.9 NM_172991 Q8BQM1 Q8C9L5 Q8K2X2 RBM48_MOUSE uc008whc.1 uc008whc.2 uc008whc.3 uc008whc.4 As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Component of the minor spliceosome. Within this complex, interacts with ARMC7 and PRPF8/PRP8. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2X2-1; Sequence=Displayed; Name=2; IsoId=Q8K2X2-2; Sequence=VSP_031785; Belongs to the RBM48 family. molecular_function nucleic acid binding RNA binding nucleoplasm biological_process uc008whc.1 uc008whc.2 uc008whc.3 uc008whc.4 
ENSMUST00000042754.7 Pth2 ENSMUST00000042754.7 parathyroid hormone 2 (from RefSeq NM_053256.2) ENSMUST00000042754.1 ENSMUST00000042754.2 ENSMUST00000042754.3 ENSMUST00000042754.4 ENSMUST00000042754.5 ENSMUST00000042754.6 NM_053256 Q91W27 Q91ZA0 TIP39_MOUSE Tip39 Tipf39 uc009gtz.1 uc009gtz.2 uc009gtz.3 This gene encodes the precursor of a peptide hormone that shares sequence similarity with the parathyroid hormone. This gene is expressed in various regions of the brain where it plays a role in the release of pituitary hormones, anxiety and nociception. The encoded precursor protein is proteolytically processed to generate the biologically active neuropeptide. Mice lacking the encoded protein display increased fear and anxiety after exposure to stressful events, and decreased sensitivity to pain. [provided by RefSeq, Aug 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY048587.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. Ligand of high affinity for the PTH2 receptor (PTH2R). Secreted. Expressed in testis and, less abundantly, in liver and kidney. Expressed in seminiferous tubuli and several brain regions, including nucleus ruber, caudal paralemniscal nucleus, nucleus centralis pontis, and nucleus subparafascicularis thalami. Expressed in neurons of cerebral cortex and subcortical areas. Expressed in Purkinje cells of cerebellum. The N-terminal truncation of tuberoinfundibular peptide of 39 residues [TIP39(7-39)] reverses PTH2R/PTHR1 binding selectivity, then is a highly potent and selective antagonist for PTHR1. Belongs to the parathyroid hormone family. receptor binding extracellular region cAMP biosynthetic process neuropeptide signaling pathway uc009gtz.1 uc009gtz.2 uc009gtz.3 
ENSMUST00000042755.7 Afp ENSMUST00000042755.7 alpha fetoprotein (from RefSeq NM_007423.4) ENSMUST00000042755.1 ENSMUST00000042755.2 ENSMUST00000042755.3 ENSMUST00000042755.4 ENSMUST00000042755.5 ENSMUST00000042755.6 FETA_MOUSE NM_007423 P02772 Q3UJD0 uc008yba.1 uc008yba.2 uc008yba.3 uc008yba.4 Binds estrogens, fatty acids and metals. Secreted. Plasma. Glycosylated; contains two glycans. Sulfated. Belongs to the ALB/AFP/VDB family. ovulation from ovarian follicle fatty acid binding extracellular region extracellular space cytoplasm zinc ion binding sexual reproduction progesterone metabolic process metal ion binding SMAD protein signal transduction uc008yba.1 uc008yba.2 uc008yba.3 uc008yba.4 
ENSMUST00000042766.6 Ppm1k ENSMUST00000042766.6 protein phosphatase 1K (PP2C domain containing), transcript variant 5 (from RefSeq NR_156746.1) ENSMUST00000042766.1 ENSMUST00000042766.2 ENSMUST00000042766.3 ENSMUST00000042766.4 ENSMUST00000042766.5 NR_156746 PPM1K_MOUSE Pp2cm Ppm1k Q8BXN7 uc009cch.1 uc009cch.2 Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (By similarity). At high levels of branched-chain ketoacids, dephosphorylates and activates mitochondrial BCKDH complex, a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Tightly associates with the E2 component of BCKDH complex and dephosphorylates BCKDHA on Ser-334 (By similarity). Regulates the reversible phosphorylation of ACLY in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. At fasting state, appears to dephosphorylate ACLY on Ser-455 and inactivate it. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). Recognizes phosphosites having SxS or RxxS motifs and strictly depends on Mn(2+) ions for the phosphatase activity (By similarity). Regulates Ca(2+)-induced opening of mitochondrial transition pore and apoptotic cell death (PubMed:17374715, PubMed:19411760) (By similarity). Reaction=H2O + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate; Xref=Rhea:RHEA:77247, Rhea:RHEA-COMP:13695, Rhea:RHEA- COMP:13696, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.52; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77248; Evidence=; Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20630; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 Mn(2+) ions per subunit. ; Protein modification. Monomer. Interacts with E1 and E2 components of the branched- chain alpha-ketoacid dehydrogenase (BCKDH) complex; this interaction requires colocalization in mitochondria. Interacts with BCKDHA but not with BCKDHB of the E1 component. Interacts with the 24-meric E2 core composed of DBT monomers with a 24:1 stoichiometry; the N-terminal region (residues 49-61) of PPM1K and C-terminal linker of the lipoyl domain of DBT (residues 145-160) are critical for this interaction, whereas the lipoyl prosthetic group is dispensable. Competes with BCKDK for binding to the E2 core; this interaction is modulated by branched- chain alpha-keto acids. At steady state, BCKDH holoenzyme preferentially binds BCKDK and BCKDHA is phosphorylated. In response to high levels of branched-chain alpha-keto acids, the inhibitory BCKDK is replaced by activating PPM1K leading to BCKDHA dephosphorylation and BCAA degradation. Mitochondrion matrix Note=Detected in the cytosolic compartment of liver cells. Highly expressed in the heart, kidney, brain and liver and to a lesser extent in testis, lung, spleen and adipose tissue. Very low amount in muscle (at protein level). Also expressed in the thymus (at protein level) and the diaphragm. Significantly reduced in hypertrophied hearts. In the developing embryos detected in heart and brain structures as early as 10.5 dpc and in liver at 14.5 dpc. Transcriptionally regulated by nutrient level of BCAAs. Mice are born at the expected Mendelian ratio and display no developmental abnormalities if fed normal diet. However high-protein diet, either during pregnancy or during the postnatal period, results in increased plasma BCAA levels and premature mortality in neonates. Belongs to the PP2C family. catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity mitochondrion mitochondrial matrix protein dephosphorylation hydrolase activity cation binding metal ion binding uc009cch.1 uc009cch.2 
ENSMUST00000042767.9 Slitrk5 ENSMUST00000042767.9 SLIT and NTRK-like family, member 5, transcript variant 1 (from RefSeq NM_198865.1) ENSMUST00000042767.1 ENSMUST00000042767.2 ENSMUST00000042767.3 ENSMUST00000042767.4 ENSMUST00000042767.5 ENSMUST00000042767.6 ENSMUST00000042767.7 ENSMUST00000042767.8 NM_198865 Q810B7 Q9CT21 SLIK5_MOUSE uc011zpr.1 uc011zpr.2 uc011zpr.3 Suppresses neurite outgrowth. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q810B7-1; Sequence=Displayed; Name=2 ; IsoId=Q810B7-2; Sequence=VSP_050708, VSP_050709, VSP_050710; In the adult, significant expression is detected only in the brain. In the embryo, expressed in the subventricular zone, cortical plate, pyramidal layer of hippocampus, thalamus and hypothalamus. Belongs to the SLITRK family. Sequence=AK011457; Type=Frameshift; Evidence=; molecular_function chemical synaptic transmission axonogenesis grooming behavior response to xenobiotic stimulus membrane integral component of membrane striatum development adult behavior receptor complex skin development dendrite morphogenesis positive regulation of synapse assembly cardiovascular system development uc011zpr.1 uc011zpr.2 uc011zpr.3 
ENSMUST00000042775.5 Neurl2 ENSMUST00000042775.5 neuralized E3 ubiquitin protein ligase 2 (from RefSeq NM_001082974.2) A2A5J5 A2A5J5_MOUSE ENSMUST00000042775.1 ENSMUST00000042775.2 ENSMUST00000042775.3 ENSMUST00000042775.4 NM_001082974 Neurl2 uc008nwk.1 uc008nwk.2 uc008nwk.3 uc008nwk.4 Protein modification; protein ubiquitination. protein ubiquitination intracellular signal transduction uc008nwk.1 uc008nwk.2 uc008nwk.3 uc008nwk.4 
ENSMUST00000042779.4 Zbtb1 ENSMUST00000042779.4 zinc finger and BTB domain containing 1, transcript variant 1 (from RefSeq NM_178744.3) ENSMUST00000042779.1 ENSMUST00000042779.2 ENSMUST00000042779.3 NM_178744 Q8CDP7 Q91VL9 Q99LD2 ZBTB1_MOUSE uc007nyd.1 uc007nyd.2 uc007nyd.3 uc007nyd.4 Acts as a transcriptional repressor (By similarity). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (By similarity). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (By similarity). Plays a key role in the transcriptional regulation of T lymphocyte development (PubMed:22201126, PubMed:22753936). Homodimer (By similarity). Homodimer (PubMed:22753936). Interacts (via BTB domain) with TRIM28 (unphosphorylated or phosphorylated form) (By similarity). Nucleus Nucleus, nucleoplasm Note=Localized in dot-like structures in the nucleus. Colocalized with SMRT in nuclear bodies. The sumoylated form is preferentially located in the nucleoplasm outside the nuclear bodies (By similarity). Expressed strongly in thymus and spleen, less in lymph nodes and peripheral blood mononuclear cells (PBMCs) and weakly in bone marrow. Strongly expressed in immature, but weakly in mature bone marrow-lymphocyte B. Both the BTB domain and C2H2-type motifs are necessary for transcriptional repression activity. The BTB domain is also necessary for oligomerization and efficient sumoylation. The hydrophobic cluster preceding Lys-328 enhanced sumoylation efficiency (By similarity). The UBZ-type zinc finger domain is required for targeting ZBTB1 to UV damage sites and for PCNA monoubiquitination. UBZ-type zinc finger domain mediates binding to 'Lys-63'-linked polyubiquitin chains (in vitro). Sumoylated with SUMO2 at Lys-328 and to a lesser extent at Lys- 266. Sumoylation inhibits its transcriptional repression activity and regulates its subcellular localization (By similarity). Thymus of embryos show a small number of T-cell progenitors that are unable to progress through thymic differentiation. Adult mice show vestigial thymus and lymph nodes and a reduced spleen size. In the periphery and in the spleen, display an absence of mature T-cells, a reduced number of NK cells, but a normal number of mature B- cells. negative regulation of transcription from RNA polymerase II promoter immune system process positive regulation of T cell mediated immunity nucleic acid binding DNA binding protein binding nucleus nucleoplasm DNA repair chromatin remodeling cellular response to DNA damage stimulus nuclear body translesion synthesis cell differentiation B cell differentiation nuclear membrane positive regulation of natural killer cell differentiation T cell differentiation in thymus cellular response to UV mRNA transcription from RNA polymerase II promoter protein homodimerization activity innate immune response positive regulation of T cell differentiation metal ion binding protein heterodimerization activity thymus development protein homooligomerization K63-linked polyubiquitin binding positive regulation of pro-T cell differentiation uc007nyd.1 uc007nyd.2 uc007nyd.3 uc007nyd.4 
ENSMUST00000042780.14 Tex2 ENSMUST00000042780.14 testis expressed gene 2 (from RefSeq NM_198292.3) B1ATR1 ENSMUST00000042780.1 ENSMUST00000042780.10 ENSMUST00000042780.11 ENSMUST00000042780.12 ENSMUST00000042780.13 ENSMUST00000042780.2 ENSMUST00000042780.3 ENSMUST00000042780.4 ENSMUST00000042780.5 ENSMUST00000042780.6 ENSMUST00000042780.7 ENSMUST00000042780.8 ENSMUST00000042780.9 Kiaa1738 NM_198292 Q6ZPJ0 TEX2_MOUSE uc007lzc.1 uc007lzc.2 uc007lzc.3 During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. Endoplasmic reticulum membrane ; Multi-pass membrane protein Nucleus membrane ; Multi- pass membrane protein Note=Enriched at the nucleus- vacuole junction (By similarity). During endoplasmic reticulum (ER) stress, localizes to ER-Golgi contacts (By similarity). The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers. Sequence=BAC98244.1; Type=Erroneous initiation; Evidence=; endoplasmic reticulum lipid transport biological_process lipid binding membrane integral component of membrane uc007lzc.1 uc007lzc.2 uc007lzc.3 
ENSMUST00000042790.5 Hspb2 ENSMUST00000042790.5 heat shock protein 2, transcript variant 1 (from RefSeq NM_024441.3) E9QKE3 ENSMUST00000042790.1 ENSMUST00000042790.2 ENSMUST00000042790.3 ENSMUST00000042790.4 HSPB2_MOUSE NM_024441 Q99PR8 Q9CZC2 uc009pkj.1 uc009pkj.2 uc009pkj.3 uc009pkj.4 May regulate the kinase DMPK. Interacts with DMPK; may enhance its kinase activity. Cytoplasm Nucleus Note=Localizes to nuclear foci. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99PR8-1; Sequence=Displayed; Name=2; IsoId=Q99PR8-2; Sequence=VSP_010160; Belongs to the small heat shock protein (HSP20) family. structural constituent of eye lens nucleus cytoplasm somatic muscle development response to heat uc009pkj.1 uc009pkj.2 uc009pkj.3 uc009pkj.4 
ENSMUST00000042792.7 Scn7a ENSMUST00000042792.7 sodium channel, voltage-gated, type VII, alpha (from RefSeq NM_009135.2) B1AYL1 B1AYL1_MOUSE ENSMUST00000042792.1 ENSMUST00000042792.2 ENSMUST00000042792.3 ENSMUST00000042792.4 ENSMUST00000042792.5 ENSMUST00000042792.6 NM_009135 Scn7a uc008jxf.1 uc008jxf.2 uc008jxf.3 uc008jxf.4 Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. B1AYL1; Q62696: Dlg1; Xeno; NbExp=3; IntAct=EBI-8068354, EBI-389325; Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the sodium channel (TC 1.A.1.10) family. Lacks conserved residue(s) required for the propagation of feature annotation. voltage-gated sodium channel complex ion channel activity voltage-gated ion channel activity voltage-gated sodium channel activity sodium channel activity protein binding plasma membrane ion transport sodium ion transport muscle contraction response to bacterium membrane integral component of membrane neuronal action potential axon regulation of ion transmembrane transport sodium ion transmembrane transport sodium ion homeostasis transmembrane transport membrane depolarization during action potential glial cell projection uc008jxf.1 uc008jxf.2 uc008jxf.3 uc008jxf.4 
ENSMUST00000042808.13 Scarf1 ENSMUST00000042808.13 scavenger receptor class F, member 1 (from RefSeq NM_001004157.2) ENSMUST00000042808.1 ENSMUST00000042808.10 ENSMUST00000042808.11 ENSMUST00000042808.12 ENSMUST00000042808.2 ENSMUST00000042808.3 ENSMUST00000042808.4 ENSMUST00000042808.5 ENSMUST00000042808.6 ENSMUST00000042808.7 ENSMUST00000042808.8 ENSMUST00000042808.9 Kiaa0149 NM_001004157 Q3V029 Q571H4 Q5ND28 SREC_MOUSE Srec uc007kea.1 uc007kea.2 uc007kea.3 Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein (By similarity). Plays a role in the regulation of neurite-like outgrowth. Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL (By similarity). Interacts with AVIL; the interaction occurs in embryonic dorsal root ganglions at 18 dpc and induces neurite-like outgrowth. Membrane ; Single-pass type I membrane protein Expressed weakly in brain, spinal cord and dorsal root ganglions. Expressed strongly in brain, spinal cord and dorsal root ganglions at 18 dpc. The cytoplasmic domain is necessary for the regulation of neurite-like outgrowth. Sequence=BAD90140.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; scavenger receptor activity protein binding plasma membrane receptor-mediated endocytosis cell adhesion positive regulation of neuron projection development membrane integral component of membrane neuron remodeling dendrite development low-density lipoprotein particle binding positive regulation of axon regeneration uc007kea.1 uc007kea.2 uc007kea.3 
ENSMUST00000042812.9 Slco1b2 ENSMUST00000042812.9 solute carrier organic anion transporter family, member 1b2 (from RefSeq NM_020495.2) ENSMUST00000042812.1 ENSMUST00000042812.2 ENSMUST00000042812.3 ENSMUST00000042812.4 ENSMUST00000042812.5 ENSMUST00000042812.6 ENSMUST00000042812.7 ENSMUST00000042812.8 NM_020495 Oatp1b2 Q9JI79 Q9JJJ1 Q9JJL3 SO1B2_MOUSE Slc21a10 uc009eoq.1 uc009eoq.2 uc009eoq.3 Mediates the Na(+)-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates (estrone 3- sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate). Also transports prostaglandin E2 and L-thyroxine (T4). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions. Reaction=estrone 3-sulfate(out) = estrone 3-sulfate(in); Xref=Rhea:RHEA:71835, ChEBI:CHEBI:60050; Evidence=; Reaction=taurocholate(out) = taurocholate(in); Xref=Rhea:RHEA:71703, ChEBI:CHEBI:36257; Evidence=; Reaction=prostaglandin E2(out) = prostaglandin E2(in); Xref=Rhea:RHEA:50984, ChEBI:CHEBI:606564; Evidence=; Reaction=L-thyroxine(out) = L-thyroxine(in); Xref=Rhea:RHEA:71819, ChEBI:CHEBI:58448; Evidence=; Cell membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JJL3-1; Sequence=Displayed; Name=2; IsoId=Q9JJL3-2; Sequence=VSP_006149; Liver specific. A conserved histidine residue in the third TMD (His-113) may play an essential role in the pH sensitivity of SLCO1B2/OATP1B2- mediated substrate transport. Belongs to the organo anion transporter (TC 2.A.60) family. liver development plasma membrane integral component of plasma membrane ion transport oligopeptide transport organic anion transmembrane transporter activity bile acid transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity bile acid and bile salt transport drug transport membrane integral component of membrane basolateral plasma membrane response to lipopolysaccharide response to lipid response to cytokine oligopeptide transmembrane transport oligopeptide transmembrane transporter activity response to drug sodium-independent organic anion transport response to peptide hormone response to antibiotic response to glucocorticoid transmembrane transport uc009eoq.1 uc009eoq.2 uc009eoq.3 
ENSMUST00000042818.11 Pim3 ENSMUST00000042818.11 proviral integration site 3 (from RefSeq NM_145478.2) ENSMUST00000042818.1 ENSMUST00000042818.10 ENSMUST00000042818.2 ENSMUST00000042818.3 ENSMUST00000042818.4 ENSMUST00000042818.5 ENSMUST00000042818.6 ENSMUST00000042818.7 ENSMUST00000042818.8 ENSMUST00000042818.9 NM_145478 Pim3 Q3TX64 Q3TX64_MOUSE uc007xeq.1 uc007xeq.2 uc007xeq.3 Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Cytoplasm Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm cytosol protein phosphorylation regulation of mitotic cell cycle kinase activity phosphorylation transferase activity negative regulation of apoptotic process uc007xeq.1 uc007xeq.2 uc007xeq.3 
ENSMUST00000042824.13 Herc1 ENSMUST00000042824.13 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (from RefSeq NM_145617.3) E9PZP8 E9PZP8_MOUSE ENSMUST00000042824.1 ENSMUST00000042824.10 ENSMUST00000042824.11 ENSMUST00000042824.12 ENSMUST00000042824.2 ENSMUST00000042824.3 ENSMUST00000042824.4 ENSMUST00000042824.5 ENSMUST00000042824.6 ENSMUST00000042824.7 ENSMUST00000042824.8 ENSMUST00000042824.9 Herc1 NM_145617 uc009qev.1 uc009qev.2 uc009qev.3 uc009qev.4 molecular_function ubiquitin-protein transferase activity cellular_component negative regulation of autophagy protein ubiquitination transferase activity cerebellar Purkinje cell differentiation neuron projection development neuromuscular process controlling balance uc009qev.1 uc009qev.2 uc009qev.3 uc009qev.4 
ENSMUST00000042834.4 Uqcrfs1 ENSMUST00000042834.4 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 (from RefSeq NM_025710.2) ENSMUST00000042834.1 ENSMUST00000042834.2 ENSMUST00000042834.3 NM_025710 Q5SVV1 Q9CR68 UCRI_MOUSE Uqcrfs1 uc007pyv.1 uc007pyv.2 uc007pyv.3 uc007pyv.4 [Cytochrome b-c1 complex subunit Rieske, mitochondrial]: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b- c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity). [Cytochrome b-c1 complex subunit 9]: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer. One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1- derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function. Reaction=a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out); Xref=Rhea:RHEA:11484, Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:132124; EC=7.1.1.8; Evidence=; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 1 [2Fe-2S] cluster per subunit. Fe-S cluster delivery to the Rieske protein is mediated by components of the iron sulfur (Fe-S) cluster assembly machinery that reside in the mitochondrial matrix (including HSC20 and LYRM7) (By similarity). ; [Cytochrome b-c1 complex subunit Rieske, mitochondrial]: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH- ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:19026783). Incorporation of the Rieske protein UQCRFS1 is the penultimate step in complex III assembly (By similarity). Interacts with TTC19, which is involved in the clearance of UQCRFS1 fragments (PubMed:28673544). [Cytochrome b-c1 complex subunit 9]: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). Subunit 9 corresponds to the mitochondrial targeting sequence (MTS) of Rieske protein UQCRFS1. It is retained after processing and incorporated inside complex III, where it remains bound to the complex and localizes between the 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2. Mitochondrion inner membrane ; Single-pass membrane protein Proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer. Several fragments are generated during UQCRFS1 insertion, most probably due to the endogenous matrix- processing peptidase (MPP) activity of the 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, which are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha- MPP respectively. The action of the protease is also necessary for the clearance of the UQCRFS1 fragments. The Rieske protein is a high potential 2Fe-2S protein. Belongs to the Rieske iron-sulfur protein family. Several peptides are generated during UQCRFS1 insertion (PubMed:28673544). According to some authors, the identification of the transit peptide as the subunit 9, does not necessary imply that it must be considered as a structural subunit of the complex III dimer as additional fragments from UQCRFS1 are also present (PubMed:28673544). protein binding mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex III mitochondrial respiratory chain complex IV plasma membrane ubiquinol-cytochrome-c reductase activity response to hormone membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on diphenols and related substances as donors electron transport chain mitochondrial membrane response to drug myelin sheath macromolecular complex binding response to antibiotic metal ion binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding oxidation-reduction process respiratory chain uc007pyv.1 uc007pyv.2 uc007pyv.3 uc007pyv.4 
ENSMUST00000042844.7 Nbl1 ENSMUST00000042844.7 NBL1, DAN family BMP antagonist (from RefSeq NM_008675.2) Dan Dana ENSMUST00000042844.1 ENSMUST00000042844.2 ENSMUST00000042844.3 ENSMUST00000042844.4 ENSMUST00000042844.5 ENSMUST00000042844.6 NBL1_MOUSE NM_008675 Q499K5 Q61477 uc008vls.1 uc008vls.2 uc008vls.3 Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. Homodimer. Secreted Belongs to the DAN family. protein binding extracellular region extracellular space signal transduction nervous system development morphogen activity negative regulation of BMP signaling pathway sequestering of BMP in extracellular matrix BMP binding sequestering of BMP from receptor via BMP binding protein homodimerization activity positive regulation of neuron differentiation determination of dorsal identity neuron projection morphogenesis negative regulation of monocyte chemotaxis uc008vls.1 uc008vls.2 uc008vls.3 
ENSMUST00000042850.9 Svep1 ENSMUST00000042850.9 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (from RefSeq NM_022814.2) A2AVA0 ENSMUST00000042850.1 ENSMUST00000042850.2 ENSMUST00000042850.3 ENSMUST00000042850.4 ENSMUST00000042850.5 ENSMUST00000042850.6 ENSMUST00000042850.7 ENSMUST00000042850.8 NM_022814 Q8C720 Q8CBT2 Q922H0 Q9CUT3 Q9ES77 SVEP1_MOUSE uc008syr.1 uc008syr.2 uc008syr.3 Required for morphological development, cell alignment and migration of lymphatic endothelial cells during embryonic development, potentially via modulation of ANGPT2-TIE1 signaling and subsequent activation of FOXC2 transcription (PubMed:28179430). Required for embryonic lymphatic vascular development, via mediating the correct formation of the first lymphovenous contact site and tight association of the lymphatic endothelium with the venous endothelium (PubMed:28179432). Represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells, via its interaction with integrins, thereby inhibiting vasocontraction (PubMed:35802072). Promotes platelet activation, via its interaction with PEAR1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). Plays a role in epidermal development and keratinocyte differentiation, independent of cell-cell adhesion (PubMed:27892606). May play a role in initial cell attachment of stromal osteogenic cells (PubMed:16206243). May promote myoblast cell adhesion when in the presence of integrin ITGA9:ITGB1 (PubMed:22654117). Interacts (via Sushi domain 21) with ITGA9:ITGB1; thereby inhibits Ca(2+) intracellular signaling and as a result represses vasocontraction (PubMed:22654117, PubMed:28179430). Interacts (via Sushi domain 21) with ITGA4:ITGB1; thereby inhibits Ca(2+) intracellular signaling and as a result represses vasocontraction (By similarity). Interacts with ANGPT1 and ANGPT2 (PubMed:28179430). Interacts with PEAR1 (via extracellular domain) (By similarity). Interacts with HSPG2, TLN1, FN1, COPA, CCT2, IQGAP1, LAMC1 and NID1 (PubMed:36792666). Interacts (via C-terminus) with TIE1 (By similarity). Secreted Nucleus Cytoplasm Membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AVA0-1; Sequence=Displayed; Name=2; IsoId=A2AVA0-2; Sequence=VSP_031629, VSP_031630; Expressed in the media layer of the arterial wall (at protein level) (PubMed:35802072). Highly expressed in lung and placenta, weakly expressed in the kidney, heart, brain and spleen (PubMed:11062057). Also expressed in bone and periosteum, but not in cartilage and skeletal muscle (PubMed:16206243). Expressed from 11 dpc to 17.5 dpc in embryos (PubMed:11062057, PubMed:22654117). Expressed by mesenchymal stem cells around the primordial thoracic duct at 12.5 dpc (at protein level) (PubMed:28179430). Initially expressed in the lungs at 15.5, expression is weakly evident in the smooth muscle layer of the lung at 16.5 dpc (at protein level) (PubMed:22654117). Expressed by mesenchymal stem cells in a fibrillar patterns around the primitive lymphatic plexus at 15.5 dpc and the collecting lymphatic vessels and valves in the skin and mesentery at 18.5 dpc (at protein level) (PubMed:28179430). Expressed at the submucosal mesenchyme in the stomach and intestine at 16.5 dpc (at protein level) (PubMed:22654117). Expressed in the sinusoids in the liver, and Bowmans capsules and inter-renal tubule mesenchyme at 16.5 dpc (at protein level) (PubMed:22654117). Expressed in the stomach and intestines at 16.5 dpc (PubMed:22654117). Expressed in the mesentery lymphatic vessel and nerve at 18.5 dpc (at protein level) (PubMed:28179432). Expressed in the bone and periosteum at birth (PubMed:16206243). Embryos display edema from 14.5 dpc onwards (PubMed:28179432). Mice are cyanotic and die within 30 minutes of birth, showing severe edema with excessive fluid accumulation in the thoracic and abdominal cavities and subcutaneous space (PubMed:28179430). The excessive accumulation of pleural fluid in the lungs impairs the inflation of the alveolar space and results in respiratory failure (PubMed:28179430). Formation of the first lymphovenous contact site develops abnormally, with spatial separation evident between the endothelial layer of the cardinal vein and the cells of the primordial thoracic duct at 12.5 dpc (PubMed:28179432). Loss of lymphatic and venous endothelium association at the prospective valve formation site at 13.5 dpc (PubMed:28179432). The dermal primitive lymphatic plexus forms however Vegfr3-positive lymphatic vessels show many bumps and size variations at 15.5 dpc (PubMed:28179430). Lymphatic vessels form secondary sprouts however lymphatic endothelial cells fail to elongate and yield rounded bumps at 18.5 dpc (PubMed:28179430). Failure of mesentery lymphatic plexus remodeling, resulting in smaller branched lymphatic vessels that fail to develop luminal valves that show increased expression levels of Flt4/Vegfr-3, Pecam1/Cd31 and Prox1 at 18.5 dpc (PubMed:28179432, PubMed:28179430). The intestinal lymphatic plexus develops as normal, however the lacteals fail to migrate into the villi at 18.5 dpc (PubMed:28179430). Extracardiac lymphatic endothelial cells migrate into the ventricular surface however migration failed to continue into the apex of the heart 18.5 dpc (PubMed:28179430). Loss of lymphatic drainage in the buccal region and hindlimb footpad at 15.5 dpc and ventral skin at 18.5 dpc (PubMed:28179430). Lymphatic endothelial cells show a cuboidal shape and fail to align longitudinally with the lymphatic flow in mesentery lymphatic vessels at 18.5 dpc (PubMed:28179430). No effect on expression of the lymphatic developmental marker Prox1 in mesenteric lymphatic endothelial cells at 16.5 and 18.5 dpc (PubMed:28179430). Expression of the lymphatic vascular maturation marker Foxc2 is significantly decreased in mesenteric lymphatic endothelial cells at both 16.5 and 18.5 dpc (PubMed:28179430). Expression of Foxc3 is also decreased in skin lymphatic endothelial cells at both 15.5 and 18.5 dpc (PubMed:28179430). Loss of the time-dependent decrease in Lyve1 expression in mesenteric lymphatic endothelial cells at 18.5 dpc (PubMed:28179430). Decrease in expression of both Tie1 and Tek/Tie2 in dermal lymphatic endothelial cells at 16.5 and 18.5 dpc (PubMed:28179430). Epidermal layers are significantly thicker at 18.5 dpc (PubMed:27892606). chromatin binding calcium ion binding extracellular region extracellular space cytoplasm cell adhesion biological_process membrane uc008syr.1 uc008syr.2 uc008syr.3 
ENSMUST00000042852.7 Fam210a ENSMUST00000042852.7 family with sequence similarity 210, member A (from RefSeq NM_153794.4) ENSMUST00000042852.1 ENSMUST00000042852.2 ENSMUST00000042852.3 ENSMUST00000042852.4 ENSMUST00000042852.5 ENSMUST00000042852.6 F210A_MOUSE NM_153794 Q3TXD0 Q8BGY7 Q8BNY5 uc008fni.1 uc008fni.2 uc008fni.3 uc008fni.4 May play a role in the structure and strength of both muscle and bone. Interacts with ATAD3A. Membrane ; Single-pass membrane protein Mitochondrion Cytoplasm Expressed in skeletal muscle, heart, brain but not in bone. Embryonic lethality in homozygotes mice after embryonic day 9.5 (PubMed:29618611). Tamoxifen-inducible Fam210a homozygous knockout mice exhibit decreased grip strength, lean mass of all limbs, bone mineral density, bone biomechanical strength, and elevated osteoclast activity with microarchitectural deterioration of trabecular and cortical bones (PubMed:29618611). Belongs to the FAM210 family. molecular_function cytoplasm mitochondrion biological_process membrane integral component of membrane uc008fni.1 uc008fni.2 uc008fni.3 uc008fni.4 
ENSMUST00000042861.7 Stx11 ENSMUST00000042861.7 syntaxin 11, transcript variant 1 (from RefSeq NM_029075.1) ENSMUST00000042861.1 ENSMUST00000042861.2 ENSMUST00000042861.3 ENSMUST00000042861.4 ENSMUST00000042861.5 ENSMUST00000042861.6 NM_029075 Q3U5V8 Q3U5V8_MOUSE Stx11 uc007ekg.1 uc007ekg.2 uc007ekg.3 uc007ekg.4 Belongs to the syntaxin family. SNAP receptor activity Golgi apparatus intracellular protein transport membrane vesicle-mediated transport membrane fusion uc007ekg.1 uc007ekg.2 uc007ekg.3 uc007ekg.4 
ENSMUST00000042868.6 Camk4 ENSMUST00000042868.6 calcium/calmodulin-dependent protein kinase IV (from RefSeq NM_009793.3) Camk4 ENSMUST00000042868.1 ENSMUST00000042868.2 ENSMUST00000042868.3 ENSMUST00000042868.4 ENSMUST00000042868.5 NM_009793 Q8BGR3 Q8BGR3_MOUSE uc008ejq.1 uc008ejq.2 uc008ejq.3 uc008ejq.4 Belongs to the protein kinase superfamily. nucleotide binding fibrillar center protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity ATP binding nucleoplasm protein phosphorylation long-term memory kinase activity phosphorylation myeloid dendritic cell differentiation positive regulation of transcription, DNA-templated postsynapse glutamatergic synapse uc008ejq.1 uc008ejq.2 uc008ejq.3 uc008ejq.4 
ENSMUST00000042889.12 Setd5 ENSMUST00000042889.12 SET domain containing 5, transcript variant 1 (from RefSeq NM_028385.1) ENSMUST00000042889.1 ENSMUST00000042889.10 ENSMUST00000042889.11 ENSMUST00000042889.2 ENSMUST00000042889.3 ENSMUST00000042889.4 ENSMUST00000042889.5 ENSMUST00000042889.6 ENSMUST00000042889.7 ENSMUST00000042889.8 ENSMUST00000042889.9 Kiaa1757 NM_028385 Q5XJV7 Q80T94 Q8BKD5 Q8BX30 SETD5_MOUSE Setd5 uc009deq.1 uc009deq.2 uc009deq.3 Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission (PubMed:30455454, PubMed:31515109). May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics (PubMed:31515109). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (PubMed:22939622). The relevance of histone methyltransferase activity is however subject to discussion (PubMed:27864380, PubMed:30455454). Reaction=L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60280, Rhea:RHEA-COMP:15542, Rhea:RHEA-COMP:15546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.367; Evidence=; Reaction=L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60324, Rhea:RHEA-COMP:9785, Rhea:RHEA- COMP:15536, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.359; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60325; Evidence=; Interacts with components of the PAF1 complex (PAF1C) such as LEO1, CTR9 and CDC73 (PubMed:27864380). Interacts with NCOR1 (PubMed:27864380). Interacts with HDAC3 (PubMed:30455454). Nucleus Chromosome Note=Localizes to active transcribed genes. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5XJV7-1; Sequence=Displayed; Name=2; IsoId=Q5XJV7-2; Sequence=VSP_024097; Name=3; IsoId=Q5XJV7-3; Sequence=VSP_024096; Ubiquitously expressed. Mid-gestation lethality due to severe developmental delay such as vascular abnormalities in the embryo and placenta, reduced cellular proliferation and increased apoptosis (PubMed:27864380). Defects are probably due to a widespread impairment in the regulation of gene expression (PubMed:27864380). Setd5- haploinsufficient mice display altered neuronal network connectivity leading to autistic-like behaviors (PubMed:30655503, PubMed:30455454, PubMed:31515109). Haploinsufficient Setd5 cortical neurons show reduced synaptic density and neuritic outgrowtho, with corresponding decreases in network activity and synchrony by electrophysiology (PubMed:30655503). Haploinsufficient mice display several autism-like behaviors, including hyperactivity, cognitive deficit, and altered social interactions (PubMed:30455454, PubMed:31515109, PubMed:30655503). According to a report, lacks histone methyltransferase activity and regulates chromatin by interacting with HDAC3 and PAF1 complex (PAF1C) complex (PubMed:30455454). According to another publication, displays histone methyltransferase activity and directly trimethylates 'Lys-36' of histone H3 (H3K36me3) (PubMed:31515109). Sequence=BAC33569.1; Type=Erroneous initiation; Evidence=; Sequence=BAC65833.1; Type=Erroneous initiation; Evidence=; protein binding nucleus nucleoplasm chromatin organization methyltransferase activity covalent chromatin modification transferase activity histone-lysine N-methyltransferase activity methylation histone lysine methylation regulation of histone acetylation histone methyltransferase activity (H3-K9 specific) histone H3-K9 methylation regulation of chromatin organization Cdc73/Paf1 complex uc009deq.1 uc009deq.2 uc009deq.3 
ENSMUST00000042901.15 Smc4 ENSMUST00000042901.15 structural maintenance of chromosomes 4, transcript variant 1 (from RefSeq NM_133786.4) Capc ENSMUST00000042901.1 ENSMUST00000042901.10 ENSMUST00000042901.11 ENSMUST00000042901.12 ENSMUST00000042901.13 ENSMUST00000042901.14 ENSMUST00000042901.2 ENSMUST00000042901.3 ENSMUST00000042901.4 ENSMUST00000042901.5 ENSMUST00000042901.6 ENSMUST00000042901.7 ENSMUST00000042901.8 ENSMUST00000042901.9 NM_133786 Q8BTS7 Q8BTY9 Q8CG47 Q99K21 SMC4_MOUSE Smc4l1 uc008pma.1 uc008pma.2 uc008pma.3 Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Forms a heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG (By similarity). Q8CG47; Q00899: Yy1; NbExp=2; IntAct=EBI-6921575, EBI-6921536; Nucleus Cytoplasm Chromosome Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase (By similarity). The SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC2, forming a V-shaped heterodimer. Belongs to the SMC family. SMC4 subfamily. single strand break repair nucleotide binding condensin complex single-stranded DNA binding protein binding ATP binding nucleus chromosome cytoplasm cytosol cell cycle mitotic chromosome condensation meiotic chromosome condensation nuclear speck chromosome condensation meiotic chromosome segregation protein heterodimerization activity chromosome organization cell division kinetochore organization uc008pma.1 uc008pma.2 uc008pma.3 
ENSMUST00000042919.16 Kdf1 ENSMUST00000042919.16 keratinocyte differentiation factor 1, transcript variant 2 (from RefSeq NM_133707.2) A2A9F4 ENSMUST00000042919.1 ENSMUST00000042919.10 ENSMUST00000042919.11 ENSMUST00000042919.12 ENSMUST00000042919.13 ENSMUST00000042919.14 ENSMUST00000042919.15 ENSMUST00000042919.2 ENSMUST00000042919.3 ENSMUST00000042919.4 ENSMUST00000042919.5 ENSMUST00000042919.6 ENSMUST00000042919.7 ENSMUST00000042919.8 ENSMUST00000042919.9 KDF1_MOUSE NM_133707 Q8C1Q5 uc008vcw.1 uc008vcw.2 uc008vcw.3 Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny. Cytoplasm Cell junction Note=Localized at cell borders in single layered keratinocytes. Localized at cell borders in the basal and spinous layers but is more diffusely localized in the granular layer. Colocalized with actin near the cell membrane, especially in cellular protrusions. Expressed in basal and suprabasal layers of the epidermis as well as within the developing hair follicles and the lumen of the esophagus at 18 dpc. Shorthand (Shd), a recessive ethylnitrosurea-induced mutant with a frameshift that results in a longer protein with the C- terminal being out of frame. Shd displays shortened and fused limbs and craniofacial malformations, including shortened snout at 12.5 dpc. The affected mice display a thickened epidermis with increased basal keratinocyte proliferation and poorly-differentiated epidermal cells that fail to form a normal barrier at 18.5 dpc. Shd homozygotes died at birth, likely due to the epidermis covering the mouth and nose openings, preventing respiration (PubMed:24075906). Sequence=BAC25177.1; Type=Frameshift; Evidence=; keratinocyte development molecular_function nucleoplasm cytoplasm cell cortex multicellular organism development regulation of epidermal cell division negative regulation of keratinocyte proliferation morphogenesis of embryonic epithelium cell junction cell differentiation cell leading edge positive regulation of epidermal cell differentiation developmental growth limb epidermis development establishment of skin barrier mitotic spindle negative regulation of stem cell proliferation uc008vcw.1 uc008vcw.2 uc008vcw.3 
ENSMUST00000042923.9 Sirt6 ENSMUST00000042923.9 sirtuin 6, transcript variant 5 (from RefSeq NR_166193.1) ENSMUST00000042923.1 ENSMUST00000042923.2 ENSMUST00000042923.3 ENSMUST00000042923.4 ENSMUST00000042923.5 ENSMUST00000042923.6 ENSMUST00000042923.7 ENSMUST00000042923.8 NR_166193 P59941 SIR6_MOUSE Sir2l6 Sirt6 uc007giy.1 uc007giy.2 uc007giy.3 uc007giy.4 NAD-dependent protein deacetylase, deacylase and mono-ADP- ribosyltransferase that plays an essential role in DNA damage repair, telomere maintenance, metabolic homeostasis, inflammation, tumorigenesis and aging (PubMed:16439206, PubMed:19135889, PubMed:20141841, PubMed:19220062, PubMed:19597350, PubMed:23217706, PubMed:23911928, PubMed:27180906, PubMed:29599436). Displays protein- lysine deacetylase or defatty-acylase (demyristoylase and depalmitoylase) activity, depending on the context (By similarity). Acts as a key histone deacetylase by catalyzing deacetylation of histone H3 at 'Lys-9', 'Lys-18' and 'Lys-56' (H3K9ac, H3K18ac and H3K56ac, respectively), suppressing target gene expression of several transcription factors, including NF-kappa-B (PubMed:19135889, PubMed:19597350, PubMed:20816089, PubMed:21098266, PubMed:25915124, PubMed:28871079, PubMed:31002797, PubMed:31399344). Acts as an inhibitor of transcription elongation by mediating deacetylation of H3K9ac and H3K56ac, preventing release of NELFE from chromatin and causing transcriptional pausing (PubMed:31399344). Involved in DNA repair by promoting double-strand break (DSB) repair: acts as a DSB sensor by recognizing and binding DSB sites, leading to (1) recruitment of DNA repair proteins, such as SMARCA5/SNF2H, and (2) deacetylation of histone H3K9ac and H3K56ac (PubMed:32538779). SIRT6 participation to DSB repair is probably involved in extension of life span (PubMed:22367546, PubMed:31002797). Also promotes DNA repair by deacetylating non-histone proteins, such as DDB2 and p53/TP53 (By similarity). Specifically deacetylates H3K18ac at pericentric heterochromatin, thereby maintaining pericentric heterochromatin silencing at centromeres and protecting against genomic instability and cellular senescence (By similarity). Involved in telomere maintenance by catalyzing deacetylation of histone H3 in telomeric chromatin, regulating telomere position effect and telomere movement in response to DNA damage (PubMed:29599436). Required for embryonic stem cell differentiation by mediating histone deacetylation of H3K9ac (PubMed:25915124, PubMed:29555651). Plays a major role in metabolism by regulating processes such as glycolysis, gluconeogenesis, insulin secretion and lipid metabolism (PubMed:20141841, PubMed:20816089, PubMed:20847051, PubMed:21098266, PubMed:23974119, PubMed:27457971, PubMed:28355567, PubMed:28250020, PubMed:34050173). Inhibits glycolysis via histone deacetylase activity and by acting as a corepressor of the transcription factor HIF1A, thereby controlling the expression of multiple glycolytic genes (PubMed:20141841). Has tumor suppressor activity by repressing glycolysis, thereby inhibiting the Warburg effect (PubMed:23217706). Also regulates glycolysis and tumorigenesis by mediating deacetylation and nuclear export of non-histone proteins, such as isoform M2 of PKM (PKM2) (By similarity). Acts as a negative regulator of gluconeogenesis by mediating deacetylation of non-histone proteins, such as FOXO1 and KAT2A/GCN5 (PubMed:23142079, PubMed:25009184). Promotes beta-oxidation of fatty acids during fasting by catalyzing deacetylation of NCOA2, inducing coactivation of PPARA (PubMed:31851938). Acts as a regulator of lipid catabolism in brown adipocytes, both by catalyzing deacetylation of histones and non- histone proteins, such as FOXO1 (PubMed:28723567, PubMed:31442424). Also acts as a regulator of circadian rhythms, both by regulating expression of clock-controlled genes involved in lipid and carbohydrate metabolism, and by catalyzing deacetylation of PER2 (PubMed:25083875, PubMed:30782483). The defatty-acylase activity is specifically involved in regulation of protein secretion (PubMed:19151729, PubMed:27322069). Has high activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as RRAS2 and TNF, thereby regulating their secretion (By similarity). Also acts as a mono-ADP-ribosyltransferase by mediating mono-ADP-ribosylation of PARP1, TRIM28/KAP1 or SMARCC2/BAF170 (PubMed:15795229, PubMed:21680843, PubMed:25247314, PubMed:31216030). Mono-ADP-ribosyltransferase activity is involved in DNA repair, cellular senescence, repression of LINE-1 retrotransposon elements and regulation of transcription (PubMed:21680843, PubMed:25247314, PubMed:30853213, PubMed:31216030, PubMed:32584788). Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43637; Evidence= Reaction=H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O- tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:70567, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:15437, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:141129, ChEBI:CHEBI:189674; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70568; Evidence=; Reaction=H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O- hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:70563, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:14175, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:138936, ChEBI:CHEBI:189673; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70564; Evidence=; Reaction=L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L- lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58220, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:15088, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:142515; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58221; Evidence=; Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D- ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19150; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Compared to the defatty-acylase activity, the protein deacetylase activity is weak in vitro, and requires activation (By similarity). The histone deacetylase activity is strongly activated upon binding to nucleosomes and chromatin in vivo (By similarity). Two molecules of SIRT6 associate with the acidic patch of one nucleosome, while the C-terminal disordered region of SIRT6 associates with nucleosomal DNA, leading to efficient histone deacetylation (By similarity). The protein-lysine deacetylase activity is also activated by long-chain free fatty-acids (By similarity). Homodimer; binds to nucleosomes and DNA ends as a homodimer (By similarity). Interacts with RELA; interferes with RELA binding to target DNA (PubMed:19135889). Interacts with SMARCA5; promoting recruitment of SMARCA5/SNF2H to double-strand breaks (DSBs) sites (By similarity). Interacts with the mTORC2 complex; preventing the ability of SIRT6 to deacetylate FOXO1 (PubMed:31442424). Interacts with the CLOCK-BMAL1 complex; recruited by the CLOCK-BMAL1 complex to regulate expression of clock-controlled genes (PubMed:25083875). Interacts with CSNK2A2; preventing CSNK2A2 localization to the nucleus (PubMed:28355567). Nucleus romosome Chromosome, telomere Endoplasmic reticulum Note=Predominantly nuclear (By similarity). Associated with pericentric heterochromatin and telomeric heterochromatin regions (By similarity). Localizes to DNA damage sites: directly recognizes and binds double-strand breaks (DSBs) sites via a tunnel-like structure that has high affinity for DSBs (By similarity). A fraction localizes to the endoplasmic reticulum (PubMed:23552949). Highest levels are found in muscle, thymus, spleen, brain and heart (at protein level). Expression peaks at embryonic day 11 and persists into adulthood. By cold (PubMed:28723567). In hepatocytes, expression is increased following incubation in a ketonic medium (PubMed:30530497). The C-terminal disordered region mediates non-specific DNA- binding. Acetylated at Lys-33 (By similarity). Deacetylation at Lys-33 by SIRT1 promotes homomultimerization and binding to double-strand breaks (DSBs) sites (By similarity). Phosphorylation at Ser-10 by MAPK8/JNK1 in response to oxidative stress stimulates the mono-ADP-ribosyltransferase activity on PARP1, leading to PARP1 recruitment to double-strand breaks (DSBs). Monoubiquitinated at Lys-170 by STUB1/CHIP, preventing its degradation by the proteasome. Sumoylated, leading to specifically decrease ability to deacetylate histone H3 at 'Lys-56' (H3K56ac). Mice display multiple defects, accelerated aging and die a few weeks after birth, because of impaired genomic stability (PubMed:16439206). Mice do not show any visible phenotype at birth and undergo a normal development during the first two weeks, except for reduced growth (PubMed:16439206). By two/three weeks of age, mice in a 129/SvJ background display severe metabolic defects and develop abnormalities usually associated with aging (PubMed:16439206, PubMed:20847051). These include acute loss of subcutaneous fat, lordokyphosis, erosion of the superficial colon epithelium, severe lymphopenia, osteopenia and severely reduced IGF1 serum levels (PubMed:16439206). Severe hypoglycemia, characterized by very low levels of blood glucose, is also observed (PubMed:16439206, PubMed:20847051). Mice also show defects in DNA double-strand break (DSB) repair (PubMed:23911928, PubMed:32538779). Derepression of LINE-1 retrotransposon elements is also observed, leading to an accumulation of cytoplasmic L1 cDNAs, which triggers the cGAS-STING pathway, driving inflammation (PubMed:30853213). Mice die about 24 days after birth (PubMed:16439206). Mice in a mixed 129/SvJ and BALB/c background reach adulthood: at 200 days of age, more than 80% of the female mice survive whereas only 10% of male mice are alive (PubMed:28448551). Mutant mice in this mixed background (129/SvJ and BALB/c) display reduced body weight, increased glucose uptake and exhibit an age-dependent progressive impairment of retinal function accompanied by thinning of retinal layers (PubMed:28448551). Sirt6-deficient mice that are haploinsufficient with p53/Tp53 display a strongly extended life span in both females and males (PubMed:29474172). Conditional deletion in the liver leads to increased glycolysis, fatty liver, triglyceride synthesis and reduced beta-oxidation (PubMed:20816089). Conditional deletion in the liver also leads to elevated LDL-cholesterol levels (PubMed:23974119). Conditional deletion in hepatocytes leads to impaired ketogenesis (PubMed:30530497). Conditional deletion in adipocytes promotes high-fat diet-induced obesity because of impaired lipolytic activity (PubMed:28723567, PubMed:28250020). Conditional deletion in pancretic beta-cells leads to glucose intolerance with severely impaired glucose-stimulated insulin secretion (PubMed:27457971). Conditional deletion in neurons leads to postnatal growth retardation and obesity (PubMed:21098266). Conditional deletion in podocytes exacerbates podocyte injury and proteinuria; defects are caused by derepression of the Notch signaling (PubMed:28871079). Compared to beaver, mouse SIRT6 displays lower histone deacetylase activity and ability to promote double-strand break (DSB) repair, possibly leading to shorter life span. Belongs to the sirtuin family. Class IV subfamily. negative regulation of transcription from RNA polymerase II promoter post-embryonic cardiac muscle cell growth involved in heart morphogenesis chromatin binding transcription corepressor activity NAD(P)+-protein-arginine ADP-ribosyltransferase activity histone deacetylase activity nucleus nucleoplasm nuclear telomeric heterochromatin cytoplasm base-excision repair protein ADP-ribosylation zinc ion binding negative regulation of cell proliferation regulation of double-strand break repair via homologous recombination hydrolase activity NAD-dependent histone deacetylase activity protein destabilization response to nutrient levels positive regulation of chromatin silencing at telomere positive regulation of telomere maintenance protein deacetylase activity glucose homeostasis negative regulation of glycolytic process negative regulation of transcription, DNA-templated negative regulation of glucose import metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) positive regulation of fibroblast proliferation histone H3-K9 modification NAD+ binding histone H3 deacetylation positive regulation of chondrocyte proliferation positive regulation of telomeric heterochromatin assembly positive regulation blood vessel branching positive regulation of vascular endothelial cell proliferation histone H3-K9 deacetylation positive regulation of stem cell proliferation nucleolus uc007giy.1 uc007giy.2 uc007giy.3 uc007giy.4 
ENSMUST00000042942.10 Sec23ip ENSMUST00000042942.10 Sec23 interacting protein, transcript variant 3 (from RefSeq NM_001420514.1) ENSMUST00000042942.1 ENSMUST00000042942.2 ENSMUST00000042942.3 ENSMUST00000042942.4 ENSMUST00000042942.5 ENSMUST00000042942.6 ENSMUST00000042942.7 ENSMUST00000042942.8 ENSMUST00000042942.9 G3X928 G3X928_MOUSE NM_001420514 Sec23ip uc009jzj.1 uc009jzj.2 uc009jzj.3 uc009jzj.4 uc009jzj.5 Belongs to the PA-PLA1 family. Golgi apparatus intracellular membrane-bounded organelle metal ion binding uc009jzj.1 uc009jzj.2 uc009jzj.3 uc009jzj.4 uc009jzj.5 
ENSMUST00000042943.13 Car10 ENSMUST00000042943.13 carbonic anhydrase 10, transcript variant 2 (from RefSeq NM_001361708.1) Car10 ENSMUST00000042943.1 ENSMUST00000042943.10 ENSMUST00000042943.11 ENSMUST00000042943.12 ENSMUST00000042943.2 ENSMUST00000042943.3 ENSMUST00000042943.4 ENSMUST00000042943.5 ENSMUST00000042943.6 ENSMUST00000042943.7 ENSMUST00000042943.8 ENSMUST00000042943.9 NM_001361708 Q3V1V7 Q3V1V7_MOUSE uc007kxi.1 uc007kxi.2 uc007kxi.3 uc007kxi.4 Does not have a catalytic activity. Belongs to the alpha-carbonic anhydrase family. carbonate dehydratase activity zinc ion binding uc007kxi.1 uc007kxi.2 uc007kxi.3 uc007kxi.4 
ENSMUST00000042944.9 Arap3 ENSMUST00000042944.9 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3, transcript variant 1 (from RefSeq NM_139206.3) ARAP3_MOUSE Centd3 Drag1 E9QMK7 ENSMUST00000042944.1 ENSMUST00000042944.2 ENSMUST00000042944.3 ENSMUST00000042944.4 ENSMUST00000042944.5 ENSMUST00000042944.6 ENSMUST00000042944.7 ENSMUST00000042944.8 Kiaa4097 NM_139206 Q5DTN4 Q6NVF1 Q8R5G6 Q8R5G7 uc008erq.1 uc008erq.2 uc008erq.3 uc008erq.4 uc008erq.5 This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase- activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts preferentially on ARF5 and on RHOA. Interacts (via SAM domain) with INPPL1/SHIP2. Q8R5G7; P07948: LYN; Xeno; NbExp=2; IntAct=EBI-621463, EBI-79452; Q8R5G7; P12931: SRC; Xeno; NbExp=3; IntAct=EBI-621463, EBI-621482; Cytoplasm Cell membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton Cell projection, lamellipodium Cell projection, ruffle Note=Cytoplasmic, and associated with F- actin-rich membrane ruffles and lamellipodia. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R5G7-1; Sequence=Displayed; Name=2; Synonyms=ARAP3 delta-SAM; IsoId=Q8R5G7-2; Sequence=VSP_015003; Name=3; IsoId=Q8R5G7-3; Sequence=VSP_015002, VSP_015004; Tyrosine phosphorylated at a low basal level. PDGF treatment stimulates phosphorylation. Tyrosine phosphorylation is increased in cells that are in the process of becoming attached to a substrate and that start spreading and flattening. Sequence=AAL78678.1; Type=Erroneous initiation; Evidence=; Sequence=BAD90507.1; Type=Erroneous initiation; Evidence=; ruffle GTPase activator activity protein binding phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm cytoskeleton plasma membrane signal transduction regulation of cell shape membrane lamellipodium negative regulation of cell migration negative regulation of Rac protein signal transduction negative regulation of Rho protein signal transduction cell projection phosphatidylinositol-3,4-bisphosphate binding positive regulation of GTPase activity uc008erq.1 uc008erq.2 uc008erq.3 uc008erq.4 uc008erq.5 
ENSMUST00000042953.10 Nbas ENSMUST00000042953.10 neuroblastoma amplified sequence, transcript variant 1 (from RefSeq NM_027706.2) E9Q411 E9Q411_MOUSE ENSMUST00000042953.1 ENSMUST00000042953.2 ENSMUST00000042953.3 ENSMUST00000042953.4 ENSMUST00000042953.5 ENSMUST00000042953.6 ENSMUST00000042953.7 ENSMUST00000042953.8 ENSMUST00000042953.9 NM_027706 Nbas uc007nbj.1 uc007nbj.2 uc007nbj.3 uc007nbj.4 SNARE binding nuclear-transcribed mRNA catabolic process endoplasmic reticulum retrograde vesicle-mediated transport, Golgi to ER Dsl1/NZR complex negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay uc007nbj.1 uc007nbj.2 uc007nbj.3 uc007nbj.4 
ENSMUST00000042954.11 Poln ENSMUST00000042954.11 DNA polymerase N, transcript variant 1 (from RefSeq NM_181857.4) A0A0R4J0E3 A0A0R4J0E3_MOUSE ENSMUST00000042954.1 ENSMUST00000042954.10 ENSMUST00000042954.2 ENSMUST00000042954.3 ENSMUST00000042954.4 ENSMUST00000042954.5 ENSMUST00000042954.6 ENSMUST00000042954.7 ENSMUST00000042954.8 ENSMUST00000042954.9 NM_181857 Poln uc008xbt.1 uc008xbt.2 uc008xbt.3 uc008xbt.4 uc008xbt.5 double-strand break repair via homologous recombination nucleic acid binding DNA binding DNA-directed DNA polymerase activity nucleus nucleoplasm DNA replication DNA-dependent DNA replication translesion synthesis cyclin binding interstrand cross-link repair uc008xbt.1 uc008xbt.2 uc008xbt.3 uc008xbt.4 uc008xbt.5 
ENSMUST00000042957.6 Krt75 ENSMUST00000042957.6 keratin 75 (from RefSeq NM_133357.3) B2RQH6 ENSMUST00000042957.1 ENSMUST00000042957.2 ENSMUST00000042957.3 ENSMUST00000042957.4 ENSMUST00000042957.5 K2C75_MOUSE Kb18 NM_133357 Q8BGZ7 uc007xtp.1 uc007xtp.2 uc007xtp.3 Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity). Heterodimer of a type I and a type II keratin (By similarity). May associate with KRT17. Expressed in the companion layer and upper germinative matrix region of the hair follicle and the medulla of the hair shaft. Also expressed in epithelia of the nail bed and fungiform papillae of dorsal tongue epithelium (at protein level). There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively). Its presence in surviving mice lacking Krt6a and Krt6b, may explain the absence of hair and nail defects in such mice. Belongs to the intermediate filament family. hematopoietic progenitor cell differentiation intermediate filament keratin filament uc007xtp.1 uc007xtp.2 uc007xtp.3 
ENSMUST00000042964.13 Zfp189 ENSMUST00000042964.13 zinc finger protein 189, transcript variant 2 (from RefSeq NM_001289901.1) ENSMUST00000042964.1 ENSMUST00000042964.10 ENSMUST00000042964.11 ENSMUST00000042964.12 ENSMUST00000042964.2 ENSMUST00000042964.3 ENSMUST00000042964.4 ENSMUST00000042964.5 ENSMUST00000042964.6 ENSMUST00000042964.7 ENSMUST00000042964.8 ENSMUST00000042964.9 NM_001289901 Q8BKP2 Q8BKP2_MOUSE Zfp189 uc033iby.1 uc033iby.2 uc033iby.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc033iby.1 uc033iby.2 uc033iby.3 
ENSMUST00000042970.3 Kcnj2 ENSMUST00000042970.3 potassium inwardly-rectifying channel, subfamily J, member 2 (from RefSeq NM_008425.4) ENSMUST00000042970.1 ENSMUST00000042970.2 Kcnj2 NM_008425 Q543W5 Q543W5_MOUSE uc007mdw.1 uc007mdw.2 uc007mdw.3 uc007mdw.4 Membrane ; Lipid- anchor Membrane ; Multi- pass membrane protein Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily. inward rectifier potassium channel activity voltage-gated ion channel activity phosphatidylinositol-4,5-bisphosphate binding smooth endoplasmic reticulum rough endoplasmic reticulum Golgi apparatus plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex intercalated disc regulation of skeletal muscle contraction via regulation of action potential membrane integral component of membrane T-tubule dendrite intrinsic component of membrane regulation of ion transmembrane transport neuronal cell body dendritic spine protein homotetramerization relaxation of cardiac muscle regulation of membrane repolarization cellular response to mechanical stimulus potassium ion transmembrane transport cardiac muscle cell action potential involved in contraction regulation of cardiac muscle cell contraction voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization membrane repolarization during action potential membrane repolarization during cardiac muscle cell action potential regulation of heart rate by cardiac conduction relaxation of skeletal muscle positive regulation of potassium ion transmembrane transport potassium ion import across plasma membrane uc007mdw.1 uc007mdw.2 uc007mdw.3 uc007mdw.4 
ENSMUST00000042971.16 Arl5c ENSMUST00000042971.16 ADP-ribosylation factor-like 5C, transcript variant 2 (from RefSeq NR_152188.1) ARL5C_MOUSE Arl12 ENSMUST00000042971.1 ENSMUST00000042971.10 ENSMUST00000042971.11 ENSMUST00000042971.12 ENSMUST00000042971.13 ENSMUST00000042971.14 ENSMUST00000042971.15 ENSMUST00000042971.2 ENSMUST00000042971.3 ENSMUST00000042971.4 ENSMUST00000042971.5 ENSMUST00000042971.6 ENSMUST00000042971.7 ENSMUST00000042971.8 ENSMUST00000042971.9 NR_152188 Q3TBK5 Q6P068 uc007lfd.1 uc007lfd.2 uc007lfd.3 uc007lfd.4 Binds and exchanges GTP and GDP. Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTP binding cytoplasm trans-Golgi network intracellular protein transport vesicle-mediated transport protein localization to Golgi membrane uc007lfd.1 uc007lfd.2 uc007lfd.3 uc007lfd.4 
ENSMUST00000042972.7 Rilp ENSMUST00000042972.7 Rab interacting lysosomal protein (from RefSeq NM_001029938.2) ENSMUST00000042972.1 ENSMUST00000042972.2 ENSMUST00000042972.3 ENSMUST00000042972.4 ENSMUST00000042972.5 ENSMUST00000042972.6 NM_001029938 Q5ND29 Q80WB8 Q8CHY9 RILP_MOUSE uc007kdz.1 uc007kdz.2 uc007kdz.3 Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes. Homodimer. Interacts with RAB7A. Interacts with RAB34 (By similarity). Identified in a complex with MREG and DCTN1; interacts directly with MREG (PubMed:22275436). Interacts with CLN3 (By similarity). Interacts with FLCN; the interaction is direct and promotes association between RILP and RAB34 (By similarity). Late endosome membrane Lysosome membrane Cytoplasmic vesicle, phagosome membrane Note=Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes. Sequence=AAH51502.1; Type=Erroneous initiation; Evidence=; protein binding mitochondrion lysosome lysosomal membrane endosome late endosome cytosol endosome to lysosome transport regulation of multivesicular body size protein transport membrane Rab GTPase binding phagocytic vesicle membrane small GTPase binding cytoplasmic vesicle late endosome membrane endosome transport via multivesicular body sorting pathway macromolecular complex negative regulation of protein catabolic process early endosome to late endosome transport positive regulation of protein catabolic process protein dimerization activity dynein light intermediate chain binding intralumenal vesicle formation uc007kdz.1 uc007kdz.2 uc007kdz.3 
ENSMUST00000042974.15 Eva1a ENSMUST00000042974.15 eva-1 homolog A, regulator of programmed cell death, transcript variant 1 (from RefSeq NM_145570.3) ENSMUST00000042974.1 ENSMUST00000042974.10 ENSMUST00000042974.11 ENSMUST00000042974.12 ENSMUST00000042974.13 ENSMUST00000042974.14 ENSMUST00000042974.2 ENSMUST00000042974.3 ENSMUST00000042974.4 ENSMUST00000042974.5 ENSMUST00000042974.6 ENSMUST00000042974.7 ENSMUST00000042974.8 ENSMUST00000042974.9 EVA1A_MOUSE Fam176a G3X936 NM_145570 Q91WM6 Tmem166 uc009clg.1 uc009clg.2 uc009clg.3 uc009clg.4 Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis. Endoplasmic reticulum membrane ; Single-pass membrane protein Lysosome membrane ; Single-pass membrane protein Belongs to the EVA1 family. molecular_function lysosome lysosomal membrane endoplasmic reticulum endoplasmic reticulum membrane plasma membrane autophagy apoptotic process biological_process membrane integral component of membrane intracellular membrane-bounded organelle uc009clg.1 uc009clg.2 uc009clg.3 uc009clg.4 
ENSMUST00000042975.7 Tmem30b ENSMUST00000042975.7 transmembrane protein 30B (from RefSeq NM_178715.3) CC50B_MOUSE Cdc50b ENSMUST00000042975.1 ENSMUST00000042975.2 ENSMUST00000042975.3 ENSMUST00000042975.4 ENSMUST00000042975.5 ENSMUST00000042975.6 NM_178715 Q8BHG3 uc007nwm.1 uc007nwm.2 uc007nwm.3 Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane (By similarity). Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 (By similarity). Cell membrane ; Multi-pass membrane protein. Belongs to the CDC50/LEM3 family. endoplasmic reticulum Golgi apparatus plasma membrane lipid transport aminophospholipid transporter activity aminophospholipid transport membrane integral component of membrane phospholipid translocation positive regulation of protein exit from endoplasmic reticulum uc007nwm.1 uc007nwm.2 uc007nwm.3 
ENSMUST00000042985.11 Cebpa ENSMUST00000042985.11 CCAAT/enhancer binding protein alpha, transcript variant 1 (from RefSeq NM_007678.4) CEBPA_MOUSE Cebp Cebpa ENSMUST00000042985.1 ENSMUST00000042985.10 ENSMUST00000042985.2 ENSMUST00000042985.3 ENSMUST00000042985.4 ENSMUST00000042985.5 ENSMUST00000042985.6 ENSMUST00000042985.7 ENSMUST00000042985.8 ENSMUST00000042985.9 NM_007678 P53566 Q91XB6 uc009gjl.1 uc009gjl.2 uc009gjl.3 uc009gjl.4 uc009gjl.5 This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in several protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Sep 2014]. Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta (PubMed:8415748, PubMed:15107404, PubMed:15589173, PubMed:36228616). Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB (PubMed:15509779). Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP) (PubMed:24367003). Critical for the proper development of the liver and the lung (PubMed:8798745). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (PubMed:1935900, PubMed:8090719). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters (PubMed:11672531). Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1 (PubMed:17627282). To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2 (PubMed:17290224). In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (PubMed:17090532). [Isoform 3]: Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation. [Isoform 4]: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation. Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPB, CEBPD, CEBPE and CEBPG (By similarity). Interacts with PRDM16 (PubMed:19641492). Interacts with UBN1 (By similarity). Interacts with ZNF638; this interaction increases transcriptional activation (PubMed:21602272). Interacts with the complex TFDP2:E2F1; the interaction prevents CEBPA binding to target gene promoters and represses its transcriptional activity (By similarity). Interacts with RB1 (PubMed:15107404). Interacts (when phosphorylated at Ser-193) with CDK2, CDK4, E2F4 and SMARCA2 (PubMed:15107404). Interacts with SREBPF1 (PubMed:17290224). Interacts with FOXO1 (via the Fork-head domain); the interaction increases when FOXO1 is deacetylated (PubMed:17090532, PubMed:17627282). Interacts with SIX1 (PubMed:27923061). Interacts (via recognition sequence) with TRIB1 (By similarity). Interacts (via bZIP domain) with OVOL2 (via zinc-finger domains); the interaction inhibits the transcription factor activity of CEBPA and is required to repress adipogenesis (PubMed:36228616). [Isoform 1]: Interacts with TAF1A and UBTF. [Isoform 4]: Interacts with TAF1A and UBTF (By similarity). Interacts with NPM1 (By similarity). P53566; Q9R1E0: Foxo1; NbExp=5; IntAct=EBI-2644207, EBI-1371343; P53566; Q6ZQ88: Kdm1a; NbExp=4; IntAct=EBI-2644207, EBI-1216284; Nucleus [Isoform 4]: Nucleus, nucleolus Event=Alternative initiation; Named isoforms=4; Name=1; IsoId=P53566-1; Sequence=Displayed; Name=2; Synonyms=C/EBPalpha-p42 ; IsoId=P53566-3; Sequence=VSP_057550; Name=3; Synonyms=C/EBPalpha-p30 ; IsoId=P53566-4; Sequence=VSP_057549; Name=4; Synonyms=extended-C/EBPalpha ; IsoId=P53566-5; Sequence=VSP_057608; Isoform 2 and isoform 3 are expressed in adipose tissue and liver (at protein level). At 9.5 dpc, expressed in the chorionic plate. From 10.5 to at least 11.5 dpc, is also expressed in the trophoblasts of the labyrinthine layer. The recognition sequence (54-72) is required for interaction with TRIB1. Sumoylated, sumoylation blocks the inhibitory effect on cell proliferation by disrupting the interaction with SMARCA2. Phosphorylation at Ser-193 is required for interaction with CDK2, CDK4 and SWI/SNF complex leading to cell cycle inhibition. Dephosphorylated at Ser-193 by protein phosphatase 2A (PP2A) through PI3K/AKT signaling pathway regulation (PubMed:15107404). Phosphorylation at Thr-222 and Thr-226 by GSK3 is constitutive in adipose tissue and lung. In liver, both Thr-222 and Thr-226 are phosphorylated only during feeding but not during fasting (PubMed:17290224). Phosphorylation of the GSK3 consensus sites selectively decreases transactivation activity on IRE-controlled promoters (PubMed:17290224). Ubiquitinated by COP1 upon interaction with TRIB1. Mutants die of hypoglycemia at 7-10 hours after birth. They have defects in the control of hepatic growth and lung development. The liver architecture is disturbed with acinar formation. They show hyperproliferation of type II pneumocytes and disturbed alveolar architecture. At the molecular level, accumulation of glycogen and lipids in the liver and adipose tissues is impaired, and the mutant animals are severely hypoglycemic (PubMed:8798745). In very few cases (less than 1%) mutants are able to survive up to 4 weeks but they are sevrely retarded in development. At 2 weeks, they are about half the size of their littermates, very thin and with skin problems. Conditional knockout in adults leads to a lack of granulopoiesis in all hematopoietic organs with no mature peripheral blood granulocytes and the presence of >30% immature myeloid cells in the bone marrow, but without anemia or thrombocytopenia. Animals rarely survive 4 to 5 weeks of age due to sepsis as a result of granulocytopenia (PubMed:15589173). Double knockout CEBPA and CEBPB results in embryonic developmental arrest and death at around 10 dpc to 11 dpc, associated with a gross placenta failure (PubMed:15509779). Belongs to the bZIP family. C/EBP subfamily. urea cycle negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase I regulatory region DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding liver development embryonic placenta development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus nucleoplasm transcription factor complex nucleolus transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase I promoter mitochondrion organization Notch signaling pathway multicellular organism development transcription factor binding cholesterol metabolic process negative regulation of cell proliferation nuclear matrix cytokine-mediated signaling pathway kinase binding protein domain specific binding myeloid cell differentiation macrophage differentiation lung development granulocyte differentiation macromolecular complex Rb-E2F complex CHOP-C/EBP complex regulation of cell proliferation glucose homeostasis protein homodimerization activity histone deacetylase binding positive regulation of macrophage activation intracellular membrane-bounded organelle sequence-specific DNA binding transcription regulatory region DNA binding macromolecular complex binding fat cell differentiation positive regulation of fat cell differentiation positive regulation of osteoblast differentiation negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase III promoter protein heterodimerization activity cell maturation inner ear development positive regulation of inflammatory response white fat cell differentiation brown fat cell differentiation lipid homeostasis interleukin-6-mediated signaling pathway cellular response to lithium ion cellular response to tumor necrosis factor cellular response to organic cyclic compound HMG box domain binding RNA polymerase II transcription factor complex positive regulation of DNA-templated transcription, initiation uc009gjl.1 uc009gjl.2 uc009gjl.3 uc009gjl.4 uc009gjl.5 
ENSMUST00000042986.10 Plcl1 ENSMUST00000042986.10 phospholipase C-like 1 (from RefSeq NM_001114663.1) D3Z0W5 ENSMUST00000042986.1 ENSMUST00000042986.2 ENSMUST00000042986.3 ENSMUST00000042986.4 ENSMUST00000042986.5 ENSMUST00000042986.6 ENSMUST00000042986.7 ENSMUST00000042986.8 ENSMUST00000042986.9 NM_001114663 PLCL1_MOUSE Q3TSM9 Q3USB7 uc007ban.1 uc007ban.2 uc007ban.3 uc007ban.4 Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol. Component in the phospho- dependent endocytosis process of GABA A receptor. Acts as an inhibitor of PPP1C (By similarity). Involved in the assembly and/or the trafficking of gamma-2 subunit-containing GABA A receptors. Interacts with PPP2CA, Ins(1,4,5)P3, Ins(1,4,5,6)P4 GABARAP, GABA receptor beta subunits, GABA receptor gamma-2 subunits and PPP1C (By similarity). May form a ternary complex with GABA receptor beta subunit and GABARAP. The formation of a ternary complex with GABA receptor beta subunit and GABARAP could be the key step for facilitating the association of GABARAP with the GABA receptor gamma-2 subunit and to allow it to be transported at the right destination. Cytoplasm Phosphorylated by the catalytic subunit of PKA. Phosphorylation of Thr-94 resulted in dissociation of PPP1C from PRIP1. In the PI-PLC X-box Asn-459 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity. phosphatidylinositol phospholipase C activity cytoplasm plasma membrane lipid metabolic process signal transduction gamma-aminobutyric acid signaling pathway phosphoric diester hydrolase activity regulation of synaptic transmission, GABAergic inositol trisphosphate biosynthetic process regulation of peptidyl-serine phosphorylation intracellular signal transduction phosphatidylinositol-mediated signaling GABA receptor binding release of sequestered calcium ion into cytosol inositol 1,4,5 trisphosphate binding positive regulation of receptor binding uc007ban.1 uc007ban.2 uc007ban.3 uc007ban.4 
ENSMUST00000042990.7 Serbp1 ENSMUST00000042990.7 serpine1 mRNA binding protein 1, transcript variant 1 (from RefSeq NM_025814.2) ENSMUST00000042990.1 ENSMUST00000042990.2 ENSMUST00000042990.3 ENSMUST00000042990.4 ENSMUST00000042990.5 ENSMUST00000042990.6 NM_025814 Pairbp1 Q8BHS2 Q8BHU0 Q91WP3 Q9CSN0 Q9CY58 Q9DBY6 SERB1_MOUSE Serbp1 uc009cfj.1 uc009cfj.2 uc009cfj.3 uc009cfj.4 Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:34815424). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A- site of the ribosome and promoting ribosome stabilization and storage in an inactive state (PubMed:34815424). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (By similarity). Seems to play a role in PML-nuclear bodies formation (By similarity). Associates with mature 80S ribosomes (PubMed:34815424). Interacts with EEF2/eEF2; interaction sequesters EEF2/eEF2 at the A- site of the ribosome, thereby blocking the interaction sites of the mRNA-tRNA complex, promoting ribosome stabilization and hibernation (PubMed:34815424). Interacts with SPIN1 (PubMed:23894536). Interacts with CHD3 and TDRD3. Interacts with ZDHHC17 (via ANK repeats) (By similarity). Cytoplasm Nucleus Cytoplasm, perinuclear region Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9CY58-1; Sequence=Displayed; Name=2; IsoId=Q9CY58-2; Sequence=VSP_011633; Name=3; IsoId=Q9CY58-3; Sequence=VSP_011632, VSP_011633; Name=4; IsoId=Q9CY58-4; Sequence=VSP_011634, VSP_011635; Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation. [Isoform 4]: May be due to intron retention. Belongs to the SERBP1-HABP4 family. RNA binding mRNA 3'-UTR binding nucleus cytoplasm cytosol plasma membrane PML body organization SUMO binding regulation of apoptotic process perinuclear region of cytoplasm uc009cfj.1 uc009cfj.2 uc009cfj.3 uc009cfj.4 
ENSMUST00000042993.7 Grifin ENSMUST00000042993.7 galectin-related inter-fiber protein (from RefSeq NM_030022.1) ENSMUST00000042993.1 ENSMUST00000042993.2 ENSMUST00000042993.3 ENSMUST00000042993.4 ENSMUST00000042993.5 ENSMUST00000042993.6 GRIFN_MOUSE NM_030022 Q9D1U0 uc009aht.1 uc009aht.2 uc009aht.3 Homodimer. The galectin domain is atypical and does not bind beta- galactoside sugars. protein binding cytoplasm biological_process carbohydrate binding uc009aht.1 uc009aht.2 uc009aht.3 
ENSMUST00000043042.10 Tmco4 ENSMUST00000043042.10 transmembrane and coiled-coil domains 4, transcript variant 1 (from RefSeq NM_001305423.1) ENSMUST00000043042.1 ENSMUST00000043042.2 ENSMUST00000043042.3 ENSMUST00000043042.4 ENSMUST00000043042.5 ENSMUST00000043042.6 ENSMUST00000043042.7 ENSMUST00000043042.8 ENSMUST00000043042.9 NM_001305423 Q8BIX8 Q91WU4 Q9D675 TMCO4_MOUSE uc056zyc.1 uc056zyc.2 uc056zyc.3 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91WU4-1; Sequence=Displayed; Name=2; IsoId=Q91WU4-2; Sequence=VSP_028243, VSP_028244, VSP_028245; Belongs to the TMCO4 family. molecular_function cellular_component biological_process membrane integral component of membrane uc056zyc.1 uc056zyc.2 uc056zyc.3 
ENSMUST00000043045.10 Wdr45 ENSMUST00000043045.10 WD repeat domain 45, transcript variant 20 (from RefSeq NR_189681.1) A2AEV3 A2AEV4 DXImx38e ENSMUST00000043045.1 ENSMUST00000043045.2 ENSMUST00000043045.3 ENSMUST00000043045.4 ENSMUST00000043045.5 ENSMUST00000043045.6 ENSMUST00000043045.7 ENSMUST00000043045.8 ENSMUST00000043045.9 NR_189681 Q91VM3 Q9CVF7 Q9JIG9 WIPI4_MOUSE Wdrx1 Wipi4 uc009smd.1 uc009smd.2 uc009smd.3 uc009smd.4 Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity. Interacts with WIPI1. Interacts with WIPI2. Interacts with ATG2A and ATG2B. Interacts with ULK1. May interact with the PRKAA1, PRKAA2, PRKAB1 and PRKAG1 subunits of the AMPK kinase. May interact with NUDC. Preautophagosomal structure Cytoplasm Note=Diffusely localized in the cytoplasm under nutrient-rich conditions. Localizes to autophagic structures during starvation-induced autophagy. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VM3-1; Sequence=Displayed; Name=2; IsoId=Q91VM3-2; Sequence=VSP_016977; The L/FRRG motif is required for recruitment to PtdIns3P. Belongs to the WD repeat PROPPIN family. autophagosome assembly pre-autophagosomal structure mitophagy cytoplasm cytosol protein lipidation autophagy lipid binding cellular response to starvation extrinsic component of membrane protein kinase binding phosphatidylinositol-3-phosphate binding pre-autophagosomal structure membrane protein localization to pre-autophagosomal structure phosphatidylinositol-3,5-bisphosphate binding phosphatidylinositol phosphate binding uc009smd.1 uc009smd.2 uc009smd.3 uc009smd.4 
ENSMUST00000043050.9 Chst12 ENSMUST00000043050.9 carbohydrate sulfotransferase 12, transcript variant 1 (from RefSeq NM_021528.4) CHSTC_MOUSE ENSMUST00000043050.1 ENSMUST00000043050.2 ENSMUST00000043050.3 ENSMUST00000043050.4 ENSMUST00000043050.5 ENSMUST00000043050.6 ENSMUST00000043050.7 ENSMUST00000043050.8 NM_021528 Q3TCX9 Q99LL3 Q9JJS3 uc009ahs.1 uc009ahs.2 uc009ahs.3 uc009ahs.4 Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O- sulfated GalNAc when chondroitin sulfate C is used as an acceptor (By similarity). Reaction=n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+); Xref=Rhea:RHEA:16101, Rhea:RHEA-COMP:9827, Rhea:RHEA-COMP:9829, ChEBI:CHEBI:15378, ChEBI:CHEBI:57652, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58422; EC=2.8.2.5; Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the sulfotransferase 2 family. Golgi membrane Golgi apparatus carbohydrate metabolic process sulfotransferase activity membrane integral component of membrane carbohydrate biosynthetic process transferase activity proteoglycan biosynthetic process chondroitin sulfate biosynthetic process dermatan sulfate biosynthetic process chondroitin 4-sulfotransferase activity uc009ahs.1 uc009ahs.2 uc009ahs.3 uc009ahs.4 
ENSMUST00000043056.9 Baat ENSMUST00000043056.9 bile acid-Coenzyme A: amino acid N-acyltransferase (from RefSeq NM_007519.3) A2AKK7 BAAT_MOUSE ENSMUST00000043056.1 ENSMUST00000043056.2 ENSMUST00000043056.3 ENSMUST00000043056.4 ENSMUST00000043056.5 ENSMUST00000043056.6 ENSMUST00000043056.7 ENSMUST00000043056.8 NM_007519 O08833 Q8C1I3 Q91X34 uc008svt.1 uc008svt.2 uc008svt.3 uc008svt.4 Catalyzes the amidation of bile acids (BAs) with the amino acid taurine (PubMed:9215542). Selective for taurine conjugation of cholyl CoA and only taurine-conjugated BAs are found in bile (PubMed:9215542). Amidation of BAs in the liver with taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (By similarity). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (By similarity). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (By similarity). In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (By similarity). Reaction=choloyl-CoA + glycine = CoA + glycocholate + H(+); Xref=Rhea:RHEA:14001, ChEBI:CHEBI:15378, ChEBI:CHEBI:29746, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57373; EC=2.3.1.65; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14002; Evidence=; Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence=; Reaction=choloyl-CoA + H2O = cholate + CoA + H(+); Xref=Rhea:RHEA:14541, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29747, ChEBI:CHEBI:57287, ChEBI:CHEBI:57373; EC=3.1.2.27; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14542; Evidence=; Reaction=chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+); Xref=Rhea:RHEA:31511, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:36234, ChEBI:CHEBI:57287, ChEBI:CHEBI:62989; EC=3.1.2.27; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31512; Evidence=; Reaction=eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+); Xref=Rhea:RHEA:40147, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32360, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40148; Evidence=; Reaction=H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate; Xref=Rhea:RHEA:30139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30140; Evidence=; Reaction=docosanoyl-CoA + H2O = CoA + docosanoate + H(+); Xref=Rhea:RHEA:40783, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:23858, ChEBI:CHEBI:57287, ChEBI:CHEBI:65059; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40784; Evidence=; Reaction=H2O + tetracosanoyl-CoA = CoA + H(+) + tetracosanoate; Xref=Rhea:RHEA:40787, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:31014, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40788; Evidence=; Reaction=H2O + hexacosanoyl-CoA = CoA + H(+) + hexacosanoate; Xref=Rhea:RHEA:40791, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:31013, ChEBI:CHEBI:57287, ChEBI:CHEBI:64868; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40792; Evidence=; Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence=; Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=; Reaction=choloyl-CoA + taurine = CoA + H(+) + taurocholate; Xref=Rhea:RHEA:47100, ChEBI:CHEBI:15378, ChEBI:CHEBI:36257, ChEBI:CHEBI:57287, ChEBI:CHEBI:57373, ChEBI:CHEBI:507393; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47101; Evidence=; Reaction=chenodeoxycholoyl-CoA + glycine = CoA + glycochenodeoxycholate + H(+); Xref=Rhea:RHEA:49788, ChEBI:CHEBI:15378, ChEBI:CHEBI:36252, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:62989; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49789; Evidence=; Reaction=chenodeoxycholoyl-CoA + taurine = CoA + H(+) + taurochenodeoxycholate; Xref=Rhea:RHEA:49784, ChEBI:CHEBI:9407, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:62989, ChEBI:CHEBI:507393; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49785; Evidence=; Reaction=eicosanoyl-CoA + glycine = CoA + H(+) + N-eicosanoylglycinate; Xref=Rhea:RHEA:49792, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57380, ChEBI:CHEBI:87391; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49793; Evidence=; Reaction=glycine + hexacosanoyl-CoA = CoA + H(+) + N- hexacosanoylglycine; Xref=Rhea:RHEA:49772, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:64868, ChEBI:CHEBI:87414; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49773; Evidence=; Reaction=docosanoyl-CoA + glycine = CoA + H(+) + N-docosanoylglycine; Xref=Rhea:RHEA:49780, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:65059, ChEBI:CHEBI:87410; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49781; Evidence=; Kinetic parameters: KM=1.9 mM for taurine toward choloyl-CoA ; Monomer. Cytoplasm, cytosol Peroxisome Highly expressed in liver, kidney, gallbladder, proximal intestine and distal intestine. Weakly expressed in adrenal gland, lung, brain and muscle. Belongs to the C/M/P thioester hydrolase family. Sequence=AAB58325.1; Type=Frameshift; Evidence=; Sequence=BAC25534.1; Type=Frameshift; Evidence=; liver development bile acid conjugation cytoplasm peroxisome cytosol glycine metabolic process lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process bile acid biosynthetic process bile acid metabolic process palmitoyl-CoA hydrolase activity N-acyltransferase activity transferase activity transferase activity, transferring acyl groups hydrolase activity thiolester hydrolase activity taurine metabolic process animal organ regeneration choloyl-CoA hydrolase activity acyl-CoA hydrolase activity glycine N-choloyltransferase activity carboxylic ester hydrolase activity medium-chain acyl-CoA hydrolase activity long-chain acyl-CoA hydrolase activity very long chain acyl-CoA hydrolase activity uc008svt.1 uc008svt.2 uc008svt.3 uc008svt.4 
ENSMUST00000043058.5 Serpina3k ENSMUST00000043058.5 serine (or cysteine) peptidase inhibitor, clade A, member 3K (from RefSeq NM_011458.2) A0A0R4J0I1 A0A0R4J0I1_MOUSE ENSMUST00000043058.1 ENSMUST00000043058.2 ENSMUST00000043058.3 ENSMUST00000043058.4 NM_011458 Serpina3k uc007oxd.1 uc007oxd.2 uc007oxd.3 Belongs to the serpin family. extracellular space uc007oxd.1 uc007oxd.2 uc007oxd.3 
ENSMUST00000043059.9 Sema7a ENSMUST00000043059.9 sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (from RefSeq NM_011352.3) Cd108 ENSMUST00000043059.1 ENSMUST00000043059.2 ENSMUST00000043059.3 ENSMUST00000043059.4 ENSMUST00000043059.5 ENSMUST00000043059.6 ENSMUST00000043059.7 ENSMUST00000043059.8 NM_011352 O88371 Q9QUR8 SEM7A_MOUSE Semal Semk1 uc009pvy.1 uc009pvy.2 uc009pvy.3 Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. Interacts with PLXNC1 (By similarity). Interacts with ITGA1 and ITGB1. Cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side Highly expressed in activated T-cells (at protein level). Highest expression in brain. Lower in heart, thymus, spleen, testis and ovary. The expression increases in late embryonic and postnatal stages. Detected in T-cells. No visible phenotype. Mice display normal levels of lymphocytes in spleen, and normal activation of T-cells by antigenic stimuli. In contrast, production of pro-inflammatory cytokines by macrophages is much reduced. The effect on contact hypersensitivity and experimental autoimmune encephalomyelitis is controversial. Reduced size of the lateral olfactory tract. Belongs to the semaphorin family. The exact role in regulating T-cell function is under debate. According to (PubMed:16713976), SEMA7A-deficient mice are highly susceptible to contact hypersensitivity and experimental autoimmune encephalomyelitis. According to (PubMed:17377534) mice do not develop contact hypersensitivity, and are highly resistant to experimental autoimmune encephalomyelitis. neural crest cell migration positive regulation of protein phosphorylation integrin binding extracellular space plasma membrane integral component of plasma membrane inflammatory response integrin-mediated signaling pathway multicellular organism development nervous system development external side of plasma membrane membrane olfactory lobe development cell differentiation semaphorin receptor binding positive regulation of cell migration neuron projection development anchored component of membrane chemorepellent activity positive regulation of axon extension axon extension negative regulation of axon extension involved in axon guidance regulation of inflammatory response negative chemotaxis positive regulation of macrophage cytokine production positive regulation of ERK1 and ERK2 cascade semaphorin-plexin signaling pathway uc009pvy.1 uc009pvy.2 uc009pvy.3 
ENSMUST00000043061.5 Shisal2b ENSMUST00000043061.5 shisa like 2B (from RefSeq NM_029984.1) ENSMUST00000043061.1 ENSMUST00000043061.2 ENSMUST00000043061.3 ENSMUST00000043061.4 Fam159b NM_029984 Q9D1Y9 SHL2B_MOUSE uc007rto.1 uc007rto.2 Membrane ; Single-pass membrane protein Belongs to the shisa family. molecular_function cellular_component biological_process membrane integral component of membrane uc007rto.1 uc007rto.2 
ENSMUST00000043062.5 Acsbg2 ENSMUST00000043062.5 acyl-CoA synthetase bubblegum family member 2 (from RefSeq NM_001039114.1) ACBG2_MOUSE Acsbg2 Bgr ENSMUST00000043062.1 ENSMUST00000043062.2 ENSMUST00000043062.3 ENSMUST00000043062.4 NM_001039114 Q2XU92 uc008ddi.1 uc008ddi.2 uc008ddi.3 Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis. Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl- CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:456215; EC=6.2.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19714; Evidence=; Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl- CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30752; Evidence=; Reaction=(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:33607, ChEBI:CHEBI:30616, ChEBI:CHEBI:30823, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33608; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)- octadecadienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:33651, ChEBI:CHEBI:30245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33652; Evidence=; Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616, ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640; Evidence=; Cytoplasm. Membrane; Peripheral membrane protein. Testis- and brainstem-specific. Expressed in pubertal and adult testis. Enriched in germ cells and Sertoli cells while present at a lower level in Leydig cells. Present in testicular Sertoli cells and large motoneurons in the medulla oblongata and cervical spinal cord (at protein level). Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. nucleotide binding long-chain fatty acid metabolic process catalytic activity acyl-CoA ligase activity long-chain fatty acid-CoA ligase activity ATP binding cytoplasm mitochondrion cytosol lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation multicellular organism development spermatogenesis membrane ligase activity cell differentiation acyl-CoA hydrolase activity arachidonate-CoA ligase activity decanoate--CoA ligase activity uc008ddi.1 uc008ddi.2 uc008ddi.3 
ENSMUST00000043069.6 Cyth4 ENSMUST00000043069.6 cytohesin 4 (from RefSeq NM_028195.3) CYH4_MOUSE ENSMUST00000043069.1 ENSMUST00000043069.2 ENSMUST00000043069.3 ENSMUST00000043069.4 ENSMUST00000043069.5 NM_028195 Pscd4 Q80YW0 uc007wpt.1 uc007wpt.2 Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity). Cell membrane ; Peripheral membrane protein Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate. Autoinhibited by its C-terminal basic region. guanyl-nucleotide exchange factor activity ARF guanyl-nucleotide exchange factor activity plasma membrane lipid binding membrane regulation of ARF protein signal transduction uc007wpt.1 uc007wpt.2 
ENSMUST00000043077.8 Thrsp ENSMUST00000043077.8 thyroid hormone responsive (from RefSeq NM_009381.3) ENSMUST00000043077.1 ENSMUST00000043077.2 ENSMUST00000043077.3 ENSMUST00000043077.4 ENSMUST00000043077.5 ENSMUST00000043077.6 ENSMUST00000043077.7 NM_009381 Q62264 S14 THRSP_MOUSE uc009ije.1 uc009ije.2 uc009ije.3 uc009ije.4 Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity). Homodimer. Heterodimer with MID1IP1. Interacts with THRB and PLAGL1 (By similarity). Q62264; Q62264: Thrsp; NbExp=3; IntAct=EBI-15853187, EBI-15853187; Q62264; G3H9D1: I79_006999; Xeno; NbExp=2; IntAct=EBI-15853187, EBI-15884821; Nucleus Cytoplasm Mainly expressed in tissues that synthesize triglycerides. Decreased lipid synthesis in the lactating mammary gland. Milk has reduced triglyceride content, causing reduced weight gain in nursing pups. Adults exhibit reduced body fat content. No effect on lipid synthesis in liver. No effect on the expression of thyroid hormone-induced lipogenic genes. Belongs to the SPOT14 family. protein binding nucleus nucleoplasm cytoplasm cytosol lipid metabolic process response to bacterium regulation of triglyceride biosynthetic process identical protein binding protein homodimerization activity regulation of lipid biosynthetic process uc009ije.1 uc009ije.2 uc009ije.3 uc009ije.4 
ENSMUST00000043082.16 Pnpla8 ENSMUST00000043082.16 patatin-like phospholipase domain containing 8 (from RefSeq NM_026164.2) ENSMUST00000043082.1 ENSMUST00000043082.10 ENSMUST00000043082.11 ENSMUST00000043082.12 ENSMUST00000043082.13 ENSMUST00000043082.14 ENSMUST00000043082.15 ENSMUST00000043082.2 ENSMUST00000043082.3 ENSMUST00000043082.4 ENSMUST00000043082.5 ENSMUST00000043082.6 ENSMUST00000043082.7 ENSMUST00000043082.8 ENSMUST00000043082.9 Ipla22 Ipla2g NM_026164 PLPL8_MOUSE Pnpla8 Q3TH33 Q8K1N1 Q8VEC0 Q9DC20 uc007nlq.1 uc007nlq.2 uc007nlq.3 uc007nlq.4 Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors (PubMed:17923475, PubMed:28442572). Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former. Has also a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono- unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine. However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling. On the other hand, can produce arachidonic acid from the sn- 1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates. Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers. Can also hydrolyze lysophosphatidylcholine (By similarity). In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition (PubMed:17923475, PubMed:28442572). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18690; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1- acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+); Xref=Rhea:RHEA:44604, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:64381, ChEBI:CHEBI:64612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44605; Evidence=; Reaction=1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = 1- O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:44068, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:77286, ChEBI:CHEBI:77287; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44069; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15178; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40571, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73003, ChEBI:CHEBI:76079; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40572; Evidence=; Reaction=1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:40643, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:58168, ChEBI:CHEBI:60000; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40644; Evidence=; Reaction=1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3- phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl- sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40651, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:58168, ChEBI:CHEBI:75063; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40652; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence=; Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:40819, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:73858, ChEBI:CHEBI:75034; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40820; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn- glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40812; Evidence=; Reaction=1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3- phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + a 1-acyl-sn- glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40639, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:64381, ChEBI:CHEBI:75069; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40640; Evidence=; Reaction=1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3- phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1- acyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40647, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:64381, ChEBI:CHEBI:75067; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40648; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40432; Evidence=; Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate; Xref=Rhea:RHEA:40823, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:75034, ChEBI:CHEBI:76071; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40824; Evidence=; Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z- docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41063, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74963, ChEBI:CHEBI:76085; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41064; Evidence=; Reaction=1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40579, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73850, ChEBI:CHEBI:77292; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40580; Evidence=; Reaction=1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine + H2O = (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn- glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:67156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:73850, ChEBI:CHEBI:86232; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67157; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phospho]-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1'-[1,2-di- (9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+); Xref=Rhea:RHEA:52812, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:83580, ChEBI:CHEBI:83581; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52813; Evidence=; Reaction=1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero- 3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O = 1'- [1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]- glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+); Xref=Rhea:RHEA:67272, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64743, ChEBI:CHEBI:133820, ChEBI:CHEBI:167908; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67273; Evidence=; Calcium-independent phospholipase. Phospholipid metabolism. Endoplasmic reticulum membrane ; Single-pass membrane protein Mitochondrion membrane ; Single-pass membrane protein Peroxisome membrane ; Single-pass membrane protein Expressed in myocardium (at protein level). Mutants display multiple bioenergetic dysfunctional phenotypes, including growth retardation, cold intolerance, reduced exercise endurance, greatly increased mortality from cardiac stress after transverse aortic constriction, abnormal mitochondrial function with a 65% decrease in ascorbate-induced Complex IV-mediated oxygen consumption, and a reduction in myocardial cardiolipin content accompanied by an altered cardiolipin molecular species composition. Myocardium of mutant mice contain more oxidized cardiolipin (PubMed:28442572). Sequence=AAH19364.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB23417.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; Golgi membrane prostaglandin biosynthetic process lysophospholipase activity cytoplasm peroxisome peroxisomal membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus lipid metabolic process fatty acid metabolic process cell death membrane integral component of membrane lipid catabolic process hydrolase activity arachidonic acid metabolic process phosphatidylcholine catabolic process linoleic acid metabolic process phosphatidylethanolamine catabolic process calcium-independent phospholipase A2 activity perinuclear region of cytoplasm arachidonic acid secretion uc007nlq.1 uc007nlq.2 uc007nlq.3 uc007nlq.4 
ENSMUST00000043089.9 Scx ENSMUST00000043089.9 scleraxis scleraxis bHLH transcription factor (from RefSeq NM_198885.3) ENSMUST00000043089.1 ENSMUST00000043089.2 ENSMUST00000043089.3 ENSMUST00000043089.4 ENSMUST00000043089.5 ENSMUST00000043089.6 ENSMUST00000043089.7 ENSMUST00000043089.8 NM_198885 Q64124 SCX_MOUSE uc007wkg.1 uc007wkg.2 uc007wkg.3 uc007wkg.4 This gene encodes a basic helix-loop-helix type transcription factor involved in mesoderm and heart valve formation. The encoded protein is expressed during embryonic development of tendons and ligaments. The gene product regulates collagen type I gene expression in cardiac fibroblasts and myofibroblasts, and it may play a role in myocardial remodeling. The protein is expressed in the scar area of the adult heart following myocardial infarction. [provided by RefSeq, Feb 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062161.1, CB204742.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages. Efficient DNA binding requires dimerization with another bHLH protein. Dimerizes and binds the E-box consensus sequence with E12. Nucleus Expressed in mesenchymal precursors of cartilage and in connective tissue. Highly expressed in tendons in the limb, tongue and diaphragm and in cartilage of the bronchi. At 6.0-6.5 dpc, expressed throughout the egg cylinder with highest expression in the epiblast. At 9.5-10.5 dpc, expressed in the lateral sclerotome and in mesenchymal cells of the limb buds and body wall. At 11.0 dpc, expressed in a metameric pattern extending along the length of the embryo. By 11.5 dpc, expression in the developing vertebrae and invertebral disks is extended caudally. High expression was seen in precursors of the ribs and bones of the limbs. Expression in progenitors of the ribs and the axial and appendicular skeleton becomes down-regulated when ossification is initiated. RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding mesoderm formation tissue homeostasis endochondral ossification chondrocyte differentiation heart valve morphogenesis heart valve formation DNA binding protein binding nucleus transcription factor complex transcription, DNA-templated multicellular organism development positive regulation of cell proliferation positive regulation of gene expression cell differentiation collagen fibril organization BMP signaling pathway positive regulation of collagen biosynthetic process skeletal muscle cell differentiation tendon development tendon cell differentiation tendon formation deltoid tuberosity development negative regulation of apoptotic process bHLH transcription factor binding sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity embryonic skeletal system development cartilage development Sertoli cell differentiation face morphogenesis regulation of cartilage development positive regulation of cartilage development sclerotome development E-box binding cellular response to mechanical stimulus cellular response to transforming growth factor beta stimulus cellular response to BMP stimulus positive regulation of gastrulation uc007wkg.1 uc007wkg.2 uc007wkg.3 uc007wkg.4 
ENSMUST00000043094.13 Itln1 ENSMUST00000043094.13 intelectin 1 (galactofuranose binding) (from RefSeq NM_010584.3) ENSMUST00000043094.1 ENSMUST00000043094.10 ENSMUST00000043094.11 ENSMUST00000043094.12 ENSMUST00000043094.2 ENSMUST00000043094.3 ENSMUST00000043094.4 ENSMUST00000043094.5 ENSMUST00000043094.6 ENSMUST00000043094.7 ENSMUST00000043094.8 ENSMUST00000043094.9 ITL1A_MOUSE Intl Itln Itln1a Itlna NM_010584 O88310 Q5IWS3 uc007doq.1 uc007doq.2 uc007doq.3 uc007doq.4 uc007doq.5 Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol- modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3- deoxy-D-manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram- positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind mammalian glycans. Probably plays a role in the defense system against microorganisms. May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (By similarity). Monomer (PubMed:17621593). May interact with LTF (By similarity). Cell membrane ; Lipid-anchor, GPI-anchor Secreted Note=Enriched in lipid rafts. Expressed in small intestinal Paneth cells in uninfected mice. Expression also detected in various other tissues including stomach, kidney, ovary and brain. In the embryo, levels are highest at day 7, decrease by mid-embryogenesis at day 11 and increase again in late embryogenesis at day 17. By infection with the helminth parasite N.brasiliensis. Mass=34000; Method=MALDI; Evidence=; Constitutive expression does not lead to enhanced immunity to N.brasiliensis or M.tuberculosis. positive regulation of protein phosphorylation calcium ion binding extracellular region plasma membrane response to nematode membrane carbohydrate binding anchored component of membrane brush border membrane identical protein binding receptor complex membrane raft positive regulation of glucose import metal ion binding protein homotrimerization oligosaccharide binding uc007doq.1 uc007doq.2 uc007doq.3 uc007doq.4 uc007doq.5 
ENSMUST00000043098.9 Gadd45a ENSMUST00000043098.9 growth arrest and DNA-damage-inducible 45 alpha (from RefSeq NM_007836.1) ENSMUST00000043098.1 ENSMUST00000043098.2 ENSMUST00000043098.3 ENSMUST00000043098.4 ENSMUST00000043098.5 ENSMUST00000043098.6 ENSMUST00000043098.7 ENSMUST00000043098.8 Gadd45a NM_007836 Q3UMH6 Q3UMH6_MOUSE uc009cfc.1 uc009cfc.2 uc009cfc.3 Nucleus Belongs to the GADD45 family. activation of MAPKKK activity nucleus cytoplasm nuclear speck kinase binding signal transduction in response to DNA damage protein homodimerization activity positive regulation of apoptotic process positive regulation of JNK cascade protein heterodimerization activity protein N-terminus binding regulation of cell cycle cellular response to mechanical stimulus cellular response to ionizing radiation mitotic cell cycle arrest positive regulation of p38MAPK cascade positive regulation of reactive oxygen species metabolic process uc009cfc.1 uc009cfc.2 uc009cfc.3 
ENSMUST00000043108.9 Zgrf1 ENSMUST00000043108.9 zinc finger, GRF-type containing 1 (from RefSeq NM_197997.2) E9Q2K6 ENSMUST00000043108.1 ENSMUST00000043108.2 ENSMUST00000043108.3 ENSMUST00000043108.4 ENSMUST00000043108.5 ENSMUST00000043108.6 ENSMUST00000043108.7 ENSMUST00000043108.8 NM_197997 Q0VGT4 ZGRF1_MOUSE uc008rhh.1 uc008rhh.2 uc008rhh.3 uc008rhh.4 5'-3' DNA helicase which is recruited to sites of DNA damage and promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR). Promotes HR by directly stimulating RAD51-mediated strand exchange activity. Not required to load RAD51 at sites of DNA damage but promotes recombinational repair after RAD51 recruitment. Also promotes HR by positively regulating EXO1-mediated DNA end resection of DNA double-strand breaks. Required for recruitment of replication protein RPA2 to DNA damage sites. Promotes the initiation of the G2/M checkpoint but not its maintenance. Catalyzes Holliday junction branch migration and dissociation of D- loops and DNA flaps. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.3; Evidence=; Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.; EC=5.6.2.3; Evidence=; Interacts with DNA repair protein RAD51; the interaction promotes RAD51 strand exchange activity. Also interacts with DNA repair proteins EXO1 and BRCA1; the interactions are increased following DNA damage induction. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0VGT4-1; Sequence=Displayed; Name=2; IsoId=Q0VGT4-2; Sequence=VSP_053245, VSP_053246; RNA binding cellular_component biological_process zinc ion binding membrane integral component of membrane uc008rhh.1 uc008rhh.2 uc008rhh.3 uc008rhh.4 
ENSMUST00000043112.9 Fbxo34 ENSMUST00000043112.9 F-box protein 34, transcript variant 1 (from RefSeq NM_030236.3) E9QM55 E9QM55_MOUSE ENSMUST00000043112.1 ENSMUST00000043112.2 ENSMUST00000043112.3 ENSMUST00000043112.4 ENSMUST00000043112.5 ENSMUST00000043112.6 ENSMUST00000043112.7 ENSMUST00000043112.8 Fbxo34 NM_030236 uc007tig.1 uc007tig.2 uc007tig.3 uc007tig.4 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. uc007tig.1 uc007tig.2 uc007tig.3 uc007tig.4 
ENSMUST00000043138.13 Inpp5f ENSMUST00000043138.13 inositol polyphosphate-5-phosphatase F, transcript variant 1 (from RefSeq NM_178641.5) ENSMUST00000043138.1 ENSMUST00000043138.10 ENSMUST00000043138.11 ENSMUST00000043138.12 ENSMUST00000043138.2 ENSMUST00000043138.3 ENSMUST00000043138.4 ENSMUST00000043138.5 ENSMUST00000043138.6 ENSMUST00000043138.7 ENSMUST00000043138.8 ENSMUST00000043138.9 Inpp5f Kiaa0966 NM_178641 Q3UCS0 Q6NX83 Q6ZQ16 Q8C8G7 Q8CBW2 Q8CDA1 SAC2_MOUSE Sac2 uc009jzc.1 uc009jzc.2 uc009jzc.3 Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869668, PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (By similarity). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (By similarity). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (PubMed:19875726). May play a role as negative regulator of axon regeneration after central nervous system injuries (PubMed:26203138). Reaction=a myo-inositol phosphate + H2O = myo-inositol + phosphate; Xref=Rhea:RHEA:24056, ChEBI:CHEBI:15377, ChEBI:CHEBI:17268, ChEBI:CHEBI:43474, ChEBI:CHEBI:84139; EC=3.1.3.25; Evidence=; Homodimer (By similarity). Interacts with OCRL and RAB5. Interacts with INPP5B and INPP4A (PubMed:25869668). Interacts with STAT3; the interaction is independent of STAT3 'Tyr-705' phosphorylation status (By similarity). Membrane, clathrin-coated pit Early endosome Recycling endosome Note=Also found on macropinosomes. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8CDA1-1; Sequence=Displayed; Name=2; IsoId=Q8CDA1-2; Sequence=VSP_033271, VSP_033274; Name=3; IsoId=Q8CDA1-3; Sequence=VSP_033270; Name=4; IsoId=Q8CDA1-4; Sequence=VSP_033272, VSP_033273; Highly expressed in brain and hypothalamus, expressed in lung and pancreas, and detected at low levels in liver and heart (at protein level). Up-regulated in the absence of histone deacetylase 2/HDAC2 in the heart from HDAC2-null mice. Animals develop normal corticospinal tract and raphespinal tract. Mutants show greater axonal growth and functional recovery after central nervous system trauma (PubMed:26203138). Knockout mice have normal cardiac form and function but show augmented hypertrophy and reactivation of the fetal gene program in response to stress compared to wild-type littermates (PubMed:19875726). INPP5F has been initially described as an inositol polyphosphate 5-phosphatase. Sequence=BAC28723.1; Type=Frameshift; Evidence=; positive regulation of receptor recycling protein binding cytoplasm endosome early endosome clathrin-coated pit adult locomotory behavior inositol monophosphate 1-phosphatase activity cardiac muscle hypertrophy in response to stress membrane hydrolase activity axon dendrite phosphatidylinositol catabolic process negative regulation of peptidyl-serine phosphorylation phosphatidylinositol phosphate 5-phosphatase activity phosphatidylinositol phosphate 4-phosphatase activity negative regulation of tyrosine phosphorylation of STAT protein phosphoric ester hydrolase activity protein homodimerization activity neuronal cell body phosphatidylinositol-4-phosphate phosphatase activity clathrin-coated endocytic vesicle phosphatidylinositol dephosphorylation phosphatidylinositol-mediated signaling negative regulation of axon regeneration regulation of protein kinase B signaling inositol monophosphate 3-phosphatase activity inositol monophosphate 4-phosphatase activity inositol monophosphate phosphatase activity recycling endosome clathrin-dependent endocytosis regulation of cell motility regulation of endocytic recycling uc009jzc.1 uc009jzc.2 uc009jzc.3 
ENSMUST00000043141.7 Hydin ENSMUST00000043141.7 HYDIN, axonemal central pair apparatus protein (from RefSeq NM_172916.2) ENSMUST00000043141.1 ENSMUST00000043141.2 ENSMUST00000043141.3 ENSMUST00000043141.4 ENSMUST00000043141.5 ENSMUST00000043141.6 HYDIN_MOUSE Hy3 NM_172916 Q3UQ06 Q68ED1 Q80W93 Q8BRL9 Q8CDF4 uc009nks.1 uc009nks.2 Required for ciliary motility. Interacts with KIF9. Cell projection, cilium Cytoplasm, cytoskeleton, cilium axoneme Note=Localizes in the cilium axoneme in a SPEF1-dependent manner. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80W93-1; Sequence=Displayed; Name=2; IsoId=Q80W93-2; Sequence=VSP_024701, VSP_024702; Name=3; IsoId=Q80W93-3; Sequence=VSP_040915, VSP_040916, VSP_040917; Expressed in brain and testis. Expressed in ciliated epithelial cells lining bronchi and oviduct, and in spermatocytes. At 15 dpc, expressed in developing choroid plexus. At P0, brain expression is limited to the ciliated ependymal cells. Note=Defects in Hydin are the cause of spontaneous hydrocephalus 3, a lethal communicating hydrocephalus with perinatal onset. There is lethality in the first weeks of life because of hydrocephalus caused by abnormal ependymal ciliary motility. Cilia are unable to bend normally, ciliary beat frequency is reduced, and the cilia tend to stall. As a result, these cilia are incapable of generating fluid flow. Similar defects are observed for cilia in trachea. Mice do not exhibit randomization of left-right body asymmetry or situs inversus. It is uncertain whether Met-1 or Met-56 is the initiator. Sequence=AAO44953.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC26807.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BB664150; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence=; epithelial cell development cilium movement molecular_function cilium multicellular organism development brain development ventricular system development cell projection trachea development axonemal central apparatus assembly axonemal central pair projection uc009nks.1 uc009nks.2 
ENSMUST00000043148.13 Gng12 ENSMUST00000043148.13 guanine nucleotide binding protein (G protein), gamma 12, transcript variant 2 (from RefSeq NM_025278.5) ENSMUST00000043148.1 ENSMUST00000043148.10 ENSMUST00000043148.11 ENSMUST00000043148.12 ENSMUST00000043148.2 ENSMUST00000043148.3 ENSMUST00000043148.4 ENSMUST00000043148.5 ENSMUST00000043148.6 ENSMUST00000043148.7 ENSMUST00000043148.8 ENSMUST00000043148.9 GBG12_MOUSE NM_025278 Q544P3 Q9DAS9 uc009cey.1 uc009cey.2 uc009cey.3 uc009cey.4 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units, alpha, beta and gamma. Cell membrane ; Lipid-anchor ; Cytoplasmic side Belongs to the G protein gamma family. GTPase activity heterotrimeric G-protein complex actin filament plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane cerebral cortex development PDZ domain binding G-protein beta/gamma-subunit complex G-protein beta-subunit binding response to lipopolysaccharide phosphate ion binding uc009cey.1 uc009cey.2 uc009cey.3 uc009cey.4 
ENSMUST00000043150.6 Acsl5 ENSMUST00000043150.6 acyl-CoA synthetase long-chain family member 5 (from RefSeq NM_027976.2) ACSL5_MOUSE Acsl5 ENSMUST00000043150.1 ENSMUST00000043150.2 ENSMUST00000043150.3 ENSMUST00000043150.4 ENSMUST00000043150.5 Facl5 NM_027976 Q8JZR0 uc008hxp.1 uc008hxp.2 uc008hxp.3 Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL (By similarity). May have a role in the survival of glioma cells (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl- CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:456215; EC=6.2.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19714; Evidence=; Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl- CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30752; Evidence=; Reaction=(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:36139, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61526, ChEBI:CHEBI:72745, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36140; Evidence=; Reaction=15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15- hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52116, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:78832, ChEBI:CHEBI:136409, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52117; Evidence=; Reaction=12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12- hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52112, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:90718, ChEBI:CHEBI:136408, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52113; Evidence=; Reaction=5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5- hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52108, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65341, ChEBI:CHEBI:136407, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52109; Evidence=; Reaction=14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15- epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52016, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:84024, ChEBI:CHEBI:136117, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52017; Evidence=; Reaction=11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12- epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52012, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:76625, ChEBI:CHEBI:136115, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52013; Evidence=; Reaction=(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:33607, ChEBI:CHEBI:30616, ChEBI:CHEBI:30823, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33608; Evidence=; Mitochondrion Endoplasmic reticulum Mitochondrion outer membrane ; Single-pass type III membrane protein Endoplasmic reticulum membrane ; Single- pass type III membrane protein Cell membrane Belongs to the ATP-dependent AMP-binding enzyme family. nucleotide binding long-chain fatty acid metabolic process catalytic activity acyl-CoA ligase activity long-chain fatty acid-CoA ligase activity ATP binding nucleus nucleolus mitochondrion mitochondrial outer membrane mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum membrane plasma membrane lipid metabolic process fatty acid metabolic process phospholipid biosynthetic process positive regulation of plasma membrane long-chain fatty acid transport positive regulation of triglyceride biosynthetic process fatty acid transport membrane integral component of membrane ligase activity positive regulation of fatty acid beta-oxidation long-chain fatty-acyl-CoA biosynthetic process arachidonate-CoA ligase activity decanoate--CoA ligase activity regulation of extrinsic apoptotic signaling pathway uc008hxp.1 uc008hxp.2 uc008hxp.3 
ENSMUST00000043151.12 Map7d2 ENSMUST00000043151.12 MAP7 domain containing 2, transcript variant 13 (from RefSeq NM_001359322.1) A2AG50 A2AG54 ENSMUST00000043151.1 ENSMUST00000043151.10 ENSMUST00000043151.11 ENSMUST00000043151.2 ENSMUST00000043151.3 ENSMUST00000043151.4 ENSMUST00000043151.5 ENSMUST00000043151.6 ENSMUST00000043151.7 ENSMUST00000043151.8 ENSMUST00000043151.9 MA7D2_MOUSE Mtap7d2 NM_001359322 Q8BLE6 Q8BMQ4 Q9D2A4 uc009usq.1 uc009usq.2 uc009usq.3 uc009usq.4 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AG50-1; Sequence=Displayed; Name=2; IsoId=A2AG50-2; Sequence=VSP_028494, VSP_028495; Name=3; IsoId=A2AG50-3; Sequence=VSP_028494, VSP_028495, VSP_028496, VSP_028497; Belongs to the MAP7 family. Sequence=BAC26896.1; Type=Frameshift; Evidence=; microtubule cytoskeleton organization microtubule cytoskeleton uc009usq.1 uc009usq.2 uc009usq.3 uc009usq.4 
ENSMUST00000043160.13 Aqr ENSMUST00000043160.13 aquarius, transcript variant 11 (from RefSeq NR_184400.1) AQR_MOUSE ENSMUST00000043160.1 ENSMUST00000043160.10 ENSMUST00000043160.11 ENSMUST00000043160.12 ENSMUST00000043160.2 ENSMUST00000043160.3 ENSMUST00000043160.4 ENSMUST00000043160.5 ENSMUST00000043160.6 ENSMUST00000043160.7 ENSMUST00000043160.8 ENSMUST00000043160.9 Kiaa0560 NR_184400 P97871 Q3U9N1 Q3ULE8 Q80TX8 Q8CFQ3 uc008lqd.1 uc008lqd.2 uc008lqd.3 uc008lqd.4 uc008lqd.5 uc008lqd.6 Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre- mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron- encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19. Within the spliceosome, interacts with SNRPA1, SF3B1, SF3B3, SF3A1 and SF3A2. Nucleus Nucleus, nucleoplasm Note=Localizes to speckle- like regions of the nucleoplasm. First detected at 8.5 dpc, when neural crest cells are visible at the lateral ridges of the neural plate. During embryogenesis, it is expressed in mesoderm, in the neural crest (and its target tissues) and in neuroepithelium. By retinoic acid (RA). Contains an N-terminal domain with structural similarity to ARM repeat regions; this domain functions as a scaffold for protein-protein interactions, but is not required for RNA binding or for ATP-dependent RNA helicase activity. Belongs to the CWF11 family. Sequence=AAB50008.1; Type=Frameshift; Evidence=; Sequence=BAC65592.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding mRNA splicing, via spliceosome RNA binding RNA helicase activity mRNA binding helicase activity ATP binding nucleus nucleoplasm spliceosomal complex mRNA processing RNA splicing hydrolase activity U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome uc008lqd.1 uc008lqd.2 uc008lqd.3 uc008lqd.4 uc008lqd.5 uc008lqd.6 
ENSMUST00000043169.14 Arel1 ENSMUST00000043169.14 apoptosis resistant E3 ubiquitin protein ligase 1, transcript variant 1 (from RefSeq NM_178065.5) AREL1_MOUSE ENSMUST00000043169.1 ENSMUST00000043169.10 ENSMUST00000043169.11 ENSMUST00000043169.12 ENSMUST00000043169.13 ENSMUST00000043169.2 ENSMUST00000043169.3 ENSMUST00000043169.4 ENSMUST00000043169.5 ENSMUST00000043169.6 ENSMUST00000043169.7 ENSMUST00000043169.8 ENSMUST00000043169.9 Kiaa0317 NM_178065 Q6P9Q1 Q80YC4 Q8C5W5 Q8CHG5 uc007oga.1 uc007oga.2 uc007oga.3 uc007oga.4 uc007oga.5 E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys- 33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages (By similarity). E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro (By similarity). Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence=; Protein modification; protein ubiquitination. Interacts with SOCS2 (PubMed:31578312). Interacts (via HECT domain) with HTRA2, DIABLO/SMAC and SEPTIN4; in the cytoplasm following induction of apoptosis (PubMed:23479728). Detected in brain, testis, heart, liver, lung and kidney with very low levels in skeletal muscle and spleen. Autoubiquitinated in vitro in the presence of E2 enzyme UBE2D1/UBCH5A. Mice show significant and stepwise decreases in indicators of inflammatory injury, such as bronchoalveolar lavage fluid protein concentration and cell count, as well as decreases in pro- inflammatory cytokine release. Sequence=BAC41414.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein polyubiquitination ubiquitin-protein transferase activity cytoplasm cytosol ubiquitin-dependent protein catabolic process apoptotic process protein ubiquitination transferase activity negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process ubiquitin protein ligase activity uc007oga.1 uc007oga.2 uc007oga.3 uc007oga.4 uc007oga.5 
ENSMUST00000043183.8 Ces2g ENSMUST00000043183.8 carboxylesterase 2G (from RefSeq NM_197999.2) Ces2g E9PV38 E9PV38_MOUSE ENSMUST00000043183.1 ENSMUST00000043183.2 ENSMUST00000043183.3 ENSMUST00000043183.4 ENSMUST00000043183.5 ENSMUST00000043183.6 ENSMUST00000043183.7 NM_197999 uc009nbk.1 uc009nbk.2 uc009nbk.3 Belongs to the type-B carboxylesterase/lipase family. extracellular space biological_process hydrolase activity carboxylic ester hydrolase activity uc009nbk.1 uc009nbk.2 uc009nbk.3 
ENSMUST00000043195.11 Gcfc2 ENSMUST00000043195.11 GC-rich sequence DNA binding factor 2, transcript variant 5 (from RefSeq NR_177926.1) ENSMUST00000043195.1 ENSMUST00000043195.10 ENSMUST00000043195.2 ENSMUST00000043195.3 ENSMUST00000043195.4 ENSMUST00000043195.5 ENSMUST00000043195.6 ENSMUST00000043195.7 ENSMUST00000043195.8 ENSMUST00000043195.9 GCFC2_MOUSE Gcf NR_177926 Q3UWF7 Q8BK44 Q8BKT3 Tcf9 uc009cld.1 uc009cld.2 uc009cld.3 Involved in pre-mRNA splicing through regulating spliceosome C complex formation (By similarity). May play a role during late-stage splicing events and turnover of excised introns (By similarity). Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors (By similarity). Interacts with TFIP11 and DHX15 (By similarity). Nucleus, nucleoplasm Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BKT3-1; Sequence=Displayed; Name=2; IsoId=Q8BKT3-2; Sequence=VSP_021799, VSP_021800; Belongs to the GCF family. Was originally thought to be a DNA-binding transcriptional repressor (By similarity). However, later work showed that the original sequence was a chimera and that the DNA-binding activity was derived from the incorrect N-terminal sequence (By similarity). Sequence=BAC34411.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter spliceosomal complex assembly RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm nucleolus cytosol regulation of transcription, DNA-templated mRNA processing RNA splicing U2-type post-mRNA release spliceosomal complex uc009cld.1 uc009cld.2 uc009cld.3 
ENSMUST00000043200.8 Smap2 ENSMUST00000043200.8 small ArfGAP 2 (from RefSeq NM_133716.3) ENSMUST00000043200.1 ENSMUST00000043200.2 ENSMUST00000043200.3 ENSMUST00000043200.4 ENSMUST00000043200.5 ENSMUST00000043200.6 ENSMUST00000043200.7 NM_133716 Q3U798 Q7TN29 SMAP2_MOUSE Smap1l uc008unw.1 uc008unw.2 uc008unw.3 GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network. Interacts with ARF1. Interacts with PICALM and clathrin heavy chains. Q7TN29; Q91VZ6: Smap1; NbExp=4; IntAct=EBI-11358641, EBI-8317690; Cytoplasm Note=Detected in multiple foci throughout the cytoplasm and in juxtanuclear structures. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TN29-1; Sequence=Displayed; Name=2; IsoId=Q7TN29-2; Sequence=VSP_018505, VSP_018506; GTPase activator activity protein binding cytoplasm positive regulation of GTPase activity metal ion binding uc008unw.1 uc008unw.2 uc008unw.3 
ENSMUST00000043204.8 Fbxo33 ENSMUST00000043204.8 F-box protein 33 (from RefSeq NM_001033156.4) A0JLR4 E9QMJ3 ENSMUST00000043204.1 ENSMUST00000043204.2 ENSMUST00000043204.3 ENSMUST00000043204.4 ENSMUST00000043204.5 ENSMUST00000043204.6 ENSMUST00000043204.7 FBX33_MOUSE NM_001033156 Q8VE08 uc007nqk.1 uc007nqk.2 uc007nqk.3 uc007nqk.4 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1. Protein modification; protein ubiquitination. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO33) formed of CUL1, SKP1, RBX1 and FBXO33. Interacts via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1 and CUL1 (By similarity). molecular_function cellular_component biological_process protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process uc007nqk.1 uc007nqk.2 uc007nqk.3 uc007nqk.4 
ENSMUST00000043208.8 Six4 ENSMUST00000043208.8 sine oculis-related homeobox 4, transcript variant 1 (from RefSeq NM_011382.3) Arec3 B2RQH3 ENSMUST00000043208.1 ENSMUST00000043208.2 ENSMUST00000043208.3 ENSMUST00000043208.4 ENSMUST00000043208.5 ENSMUST00000043208.6 ENSMUST00000043208.7 NM_011382 Q61321 Q61322 Q61323 SIX4_MOUSE uc007nwb.1 uc007nwb.2 uc007nwb.3 Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and from a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer (PubMed:14966291). Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein (PubMed:10490620). Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1 (PubMed:15788460). Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6 (PubMed:15788460, PubMed:17592144). Controls somitic differentiation in myocyte through MYOG transactivation (PubMed:15788460). Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3 (PubMed:19962975, PubMed:21884692). Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes (PubMed:21884692). During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression (PubMed:20696153). During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression (PubMed:17300925). Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation (PubMed:23987514). During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation (PubMed:19027001). Promotes survival of sensory neurons during early trigeminal gangliogenesis (PubMed:16938278). In the developing dorsal root ganglia, up-regulates SLC12A2 transcription (PubMed:15955062). Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression (PubMed:16530750). Forms gustatory papillae during development of the tongue (PubMed:21978088). Also plays a role during embryonic cranial skeleton morphogenesis (PubMed:20515681). Interacts with EYA3; acts cooperatively with EYA3 to transactivate target genes through interaction and nuclear translocation of EYA3 protein (PubMed:12215533, PubMed:10490620). Q61321; O70546: Kdm6a; NbExp=2; IntAct=EBI-986524, EBI-1573712; Nucleus toplasm Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=SM; IsoId=Q61321-1; Sequence=Displayed; Name=2; Synonyms=M18; IsoId=Q61321-2; Sequence=VSP_002293, VSP_002294; Name=3; Synonyms=M8; IsoId=Q61321-3; Sequence=VSP_002293, VSP_002295, VSP_002296; Mainly expressed in the skeletal muscle (isoform 1 and isoform 2 but not isoform 3), and weakly in the heart. Also found in the retina and the distal tube of kidney. Expressed in skeletal muscle, nasal epithelium, cochlea, parathyroid and salivary gland (PubMed:11313460). Expressed in muscle satellite cells of normal and regenerating muscles (PubMed:20696153). At 8.5 dpc expressed at the surface ectoderm outside the neural folds, somites, presomitic mesoderm. At 9.5 dpc expressed at the nasal and otic placodes, cranial ganglia, branchial arches, somites (dermamyotomes and sclerotomes). At 10.5-11.5 dpc expressed at the nasal pits, otic vesicles, cranial ganglia, dorsal root ganglia, branchial arches, somites, myotomes, limb mesenchyme, notochord, mesonephros. At 12.5-13.5 dpc expressed in skeletal muscles, mesenchyme in limbs and digits, nasal epithelium, inner ear (PubMed:11313460). Weakly expressed in the nephrogenic cord on 9.5 dpc and in the metanephric mesenchyme on 10.5 dpc (PubMed:17300925). At 11.5 dpc expressed in the epithelium of the lateral lingual swellings, and in the tongue epithelium, mesenchyme, and muscles at 12.5 dpc. In the fungiform papillae, expressed in the epithelium at 14-16.5 dpc. In the circumvallate and foliate papillae, expression is observed in the trench wall of these papillae at 15.5 dpc-P0 (PubMed:21978088). At 11.5 dpc mainly found in limbs, and somites, where is expressed in the dorsal root ganglion, myotomes, and ventral and dorsal dermomyotomal lips (PubMed:15788460). Expressed in a wide domain of the ectoderm in the presumptive olfactory region and in the thickened olfactory placode. Expressed in the peripheral precursors of the pit. At 12.5 dpc-14.5 dpc, expression become progressively restricted to the apical and basal progenitors.Also expressed strongly in the preplacodal region at 8.0 dpc and in the presumptive olfactory ectoderm at 9.0 dpc (PubMed:19027001). At 10.5 dpc expressed in the progenitors of the dermomyotome and in the myocytes (PubMed:19962975). Mice are viable and fertile; no gross morphological or histological abnormalities, or defects in hearing ability are detected in homozygous mice (PubMed:11313460). Double homozygous SIX1 and SIX4 knockout mice die soon after birth and show developmental defects in various organs (PubMed:15955062). Double homozygous SIX1 and SIX4 knockout mice causes severe defects in the trigeminal ganglia (PubMed:16938278). Double homozygous SIX1 and SIX4 knockout mice exhibit more severe kidney phenotypes than the SIX1 knockout mice. Double homozygous SIX1 and SIX4 knockout embryos show distinct morphological changes: fusion of the lateral lingual swellings is delayed, and the tongue is poorly developed. The primordia of fungiform papillae appears earlier, and the papillae rapidly increases in size; thus fusion of each papilla is evident. The circumvallate papillae show severe defects: invagination of the trenches starts asymmetrically, which results in longer and shorter trenches (PubMed:21978088). Double homozygous SIX1 and SIX4 knockout neonatal mice have a male-to-female sex-reversal phenotype in XY mutant gonads (PubMed:23987514). Double homozygous SIX1 and SIX4 knockout neonatal mice are characterized by severe craniofacial and rib defects, and general muscle hypoplasia (PubMed:15788460). [Isoform 2]: Incomplete sequence. [Isoform 3]: Incomplete sequence. Belongs to the SIX/Sine oculis homeobox family. transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm regulation of transcription, DNA-templated multicellular organism development skeletal muscle tissue development regulation of synaptic growth at neuromuscular junction male gonad development regulation of gene expression male sex determination olfactory placode formation regulation of protein localization protein localization to nucleus inner ear morphogenesis negative regulation of apoptotic process negative regulation of neuron apoptotic process sequence-specific DNA binding tongue development sarcomere organization negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter male sex differentiation thymus development generation of neurons embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis anatomical structure development regulation of epithelial cell proliferation myoblast migration pharyngeal system development myotome development fungiform papilla morphogenesis trigeminal ganglion development metanephric mesenchyme development regulation of branch elongation involved in ureteric bud branching positive regulation of ureteric bud formation positive regulation of branching involved in ureteric bud morphogenesis skeletal muscle fiber differentiation negative regulation of satellite cell differentiation uc007nwb.1 uc007nwb.2 uc007nwb.3 
ENSMUST00000043214.8 Rac2 ENSMUST00000043214.8 Rac family small GTPase 2 (from RefSeq NM_009008.3) ENSMUST00000043214.1 ENSMUST00000043214.2 ENSMUST00000043214.3 ENSMUST00000043214.4 ENSMUST00000043214.5 ENSMUST00000043214.6 ENSMUST00000043214.7 NM_009008 Q05144 Q3TBC4 Q9D8X9 RAC2_MOUSE uc007wpp.1 uc007wpp.2 uc007wpp.3 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Interacts with DOCK2, which may activate it. Interacts with S100A8 and calprotectin (S100A8/9) (By similarity). Found in a complex with SH3RF1, MAP3K7/TAK1, MAP2K7/MKK7, MAPK8IP1/JIP1, MAPK8/JNK1 and MAPK9/JNK2 (PubMed:27084103). Interacts with PAK1 (By similarity). Cytoplasm Membrane ; Lipid-anchor Note=Membrane-associated when activated. Belongs to the small GTPase superfamily. Rho family. nucleotide binding GTPase activity GTP binding nuclear envelope cytoplasm cytosol actin filament plasma membrane cell cortex chemotaxis actin filament organization establishment or maintenance of cell polarity G-protein coupled receptor signaling pathway small GTPase mediated signal transduction Rho protein signal transduction motor neuron axon guidance positive regulation of cell proliferation regulation of cell shape positive regulation of lamellipodium assembly regulation of cell-substrate adhesion membrane Rac protein signal transduction protein kinase regulator activity protein kinase binding lamellipodium cell projection assembly actin cytoskeleton organization regulation of actin cytoskeleton organization regulation of T cell proliferation cell projection regulation of mast cell degranulation engulfment of apoptotic cell bone resorption regulation of protein kinase activity regulation of respiratory burst regulation of mast cell chemotaxis lymphocyte aggregation positive regulation of neutrophil chemotaxis regulation of neutrophil migration uc007wpp.1 uc007wpp.2 uc007wpp.3 
ENSMUST00000043227.13 Rcbtb1 ENSMUST00000043227.13 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1, transcript variant 1 (from RefSeq NM_027764.2) A0A0R4J025 A0A0R4J025_MOUSE ENSMUST00000043227.1 ENSMUST00000043227.10 ENSMUST00000043227.11 ENSMUST00000043227.12 ENSMUST00000043227.2 ENSMUST00000043227.3 ENSMUST00000043227.4 ENSMUST00000043227.5 ENSMUST00000043227.6 ENSMUST00000043227.7 ENSMUST00000043227.8 ENSMUST00000043227.9 NM_027764 Rcbtb1 uc007ueb.1 uc007ueb.2 uc007ueb.3 cytoplasm uc007ueb.1 uc007ueb.2 uc007ueb.3 
ENSMUST00000043235.8 Tiprl ENSMUST00000043235.8 TIP41, TOR signalling pathway regulator-like (S. cerevisiae), transcript variant 1 (from RefSeq NM_145513.4) ENSMUST00000043235.1 ENSMUST00000043235.2 ENSMUST00000043235.3 ENSMUST00000043235.4 ENSMUST00000043235.5 ENSMUST00000043235.6 ENSMUST00000043235.7 NM_145513 Q8BH58 TIPRL_MOUSE uc007diz.1 uc007diz.2 uc007diz.3 uc007diz.4 May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma- H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity). Interacts with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C. Interacts with IGBP1; the interaction is dependent on PPP2CA. Associates with a protein phosphatase 2A PP2A(C):IGBP1 complex (By similarity). Interacts with PPP4C and PPP4R2 (PubMed:26717153). Cytoplasm Belongs to the TIP41 family. DNA damage checkpoint molecular_function cytoplasm cytosol signal transduction negative regulation of phosphoprotein phosphatase activity regulation of phosphoprotein phosphatase activity uc007diz.1 uc007diz.2 uc007diz.3 uc007diz.4 
ENSMUST00000043237.14 Trp53inp2 ENSMUST00000043237.14 transformation related protein 53 inducible nuclear protein 2, transcript variant 1 (from RefSeq NM_178111.4) Dor ENSMUST00000043237.1 ENSMUST00000043237.10 ENSMUST00000043237.11 ENSMUST00000043237.12 ENSMUST00000043237.13 ENSMUST00000043237.2 ENSMUST00000043237.3 ENSMUST00000043237.4 ENSMUST00000043237.5 ENSMUST00000043237.6 ENSMUST00000043237.7 ENSMUST00000043237.8 ENSMUST00000043237.9 NM_178111 Q3TDL6 Q711P5 Q8CFU8 Q8CHM4 T53I2_MOUSE Tp53inp2 uc008nkk.1 uc008nkk.2 uc008nkk.3 Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. Interacts with VMP1, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3C and THRA. Cytoplasm, cytosol Nucleus Nucleus, PML body Cytoplasmic vesicle, autophagosome Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CFU8-1; Sequence=Displayed; Name=2; IsoId=Q8CFU8-2; Sequence=VSP_007752; The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C. autophagosome assembly osteoblast differentiation tissue homeostasis nucleus cytoplasm autophagosome cytosol ubiquitin-dependent protein catabolic process autophagy positive regulation of autophagy macroautophagy PML body cytoplasmic vesicle ubiquitin binding positive regulation of transcription, DNA-templated negative regulation of cellular protein localization uc008nkk.1 uc008nkk.2 uc008nkk.3 
ENSMUST00000043249.10 Mcpt4 ENSMUST00000043249.10 mast cell protease 4 (from RefSeq NM_010779.2) ENSMUST00000043249.1 ENSMUST00000043249.2 ENSMUST00000043249.3 ENSMUST00000043249.4 ENSMUST00000043249.5 ENSMUST00000043249.6 ENSMUST00000043249.7 ENSMUST00000043249.8 ENSMUST00000043249.9 Mcpt4 NM_010779 Q3UN88 Q3UN88_MOUSE uc007ubl.1 uc007ubl.2 uc007ubl.3 serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc007ubl.1 uc007ubl.2 uc007ubl.3 
ENSMUST00000043259.10 Pde3a ENSMUST00000043259.10 phosphodiesterase 3A, cGMP inhibited (from RefSeq NM_018779.2) ENSMUST00000043259.1 ENSMUST00000043259.2 ENSMUST00000043259.3 ENSMUST00000043259.4 ENSMUST00000043259.5 ENSMUST00000043259.6 ENSMUST00000043259.7 ENSMUST00000043259.8 ENSMUST00000043259.9 NM_018779 PDE3A_MOUSE Pde3a Q9Z0X4 uc009eoo.1 uc009eoo.2 uc009eoo.3 Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:11420239). Has also activity toward cUMP (By similarity). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro- apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (By similarity). Reaction=a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'- phosphate + H(+); Xref=Rhea:RHEA:14653, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57867, ChEBI:CHEBI:58464; EC=3.1.4.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14654; Evidence=; Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278; Evidence=; Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, ChEBI:CHEBI:58115; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16958; Evidence=; Reaction=3',5'-cyclic UMP + H2O = H(+) + UMP; Xref=Rhea:RHEA:70575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57865, ChEBI:CHEBI:184387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70576; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 divalent metal cations per subunit. ; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 divalent metal cations per subunit. ; Inhibited by cGMP. Kinetic parameters: KM=0.2 uM for 3',5'-cyclic AMP ; Membrane ; Multi- pass membrane protein Cytoplasm, cytosol Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily. oocyte maturation 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cytosol signal transduction phosphoric diester hydrolase activity membrane integral component of membrane hydrolase activity cAMP-mediated signaling cGMP-mediated signaling regulation of meiotic nuclear division response to drug negative regulation of apoptotic process negative regulation of vascular permeability positive regulation of vascular permeability negative regulation of cAMP-mediated signaling metal ion binding positive regulation of oocyte development cellular response to cGMP cellular response to transforming growth factor beta stimulus uc009eoo.1 uc009eoo.2 uc009eoo.3 
ENSMUST00000043266.7 4930596D02Rik ENSMUST00000043266.7 RIKEN cDNA 4930596D02 gene (from RefSeq NM_001033766.3) 4930596D02Rik ENSMUST00000043266.1 ENSMUST00000043266.2 ENSMUST00000043266.3 ENSMUST00000043266.4 ENSMUST00000043266.5 ENSMUST00000043266.6 NM_001033766 Q3V0H9 Q3V0H9_MOUSE uc007tbk.1 uc007tbk.2 uc007tbk.3 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc007tbk.1 uc007tbk.2 uc007tbk.3 
ENSMUST00000043273.16 U2af1l4 ENSMUST00000043273.16 U2 small nuclear RNA auxiliary factor 1-like 4 (from RefSeq NM_170760.3) ENSMUST00000043273.1 ENSMUST00000043273.10 ENSMUST00000043273.11 ENSMUST00000043273.12 ENSMUST00000043273.13 ENSMUST00000043273.14 ENSMUST00000043273.15 ENSMUST00000043273.2 ENSMUST00000043273.3 ENSMUST00000043273.4 ENSMUST00000043273.5 ENSMUST00000043273.6 ENSMUST00000043273.7 ENSMUST00000043273.8 ENSMUST00000043273.9 NM_170760 Q8BGJ9 U2AF4_MOUSE U2af26 uc009gfa.1 uc009gfa.2 uc009gfa.3 RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. It can functionally substitute for U2AF1 in constitutive splicing and enhancer-dependent splicing. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Shows a preference for AGC or AGA (PubMed:11739736, PubMed:16819553, PubMed:18460468). Alternative splicing of U2AF1L4 may play a role in connecting the circadian rhythm to changing external cues: may provide a circadian buffering system in central and periphery clocks that allows synchronized adaption to clock-resetting stimuli in order to prevent potentially pathogenic desynchronization (PubMed:24837677). Interacts with GFI1, U2AF2 and C1QBP. Isoform 3 interacts with PER1. Q8BGJ9; O35658: C1qbp; NbExp=4; IntAct=EBI-4288480, EBI-642072; Q8BGJ9; P70338: Gfi1; NbExp=5; IntAct=EBI-4288480, EBI-3954754; [Isoform 1]: Nucleus Nucleus speckle Cytoplasm te=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo-cytoplasmic shuttling. [Isoform 3]: Cytoplasm [Isoform 2]: Cytoplasm Event=Alternative splicing; Named isoforms=4; Comment=Circadian and light-inducible alternative splicing, which occurs at least in brain and liver.; Name=1; Synonyms=fl ; IsoId=Q8BGJ9-1; Sequence=Displayed; Name=2; Synonyms=U2AF26DeltaE7, DE7 IsoId=Q8BGJ9-2; Sequence=VSP_056877; Name=3; Synonyms=U2AF26DeltaE67, DE67 IsoId=Q8BGJ9-3; Sequence=VSP_056875; Name=4; IsoId=Q8BGJ9-4; Sequence=VSP_056874, VSP_056876; Ubiquitous. Highly expressed in the brain. Up-regulated in response to T-cell activation (at protein level) (PubMed:16819553). Circadian alternative splicing switch accounts for rhythmic isoform expression. A circadian splicing switch produces isoform 3 in the brain cerebellum and liver (at protein level). Isoform 3 expression is regulated with the circadian rhythm but is also quickly increased upon light exposure (4-8 hours after light exposure). Expression of isoform 3 changes approximately 5-fold across a period of 24 hours, with concomitant changes in isoform 1, resulting in total U2af1l4 remaining constant (PubMed:24837677). The second zinc finger in necessary for interaction with GFI1 and for alternative pre-mRNA splicing events. The region 162-220 is essential for the nuclear import of the protein in spite of the absence of a nuclear localization signal (NLS). This region is essential for the interaction with C1QBP, interaction which is required for the nuclear translocation. This region may be involved in the localization in nuclear dot-like structures and it also confers the ability of nucleo-cytoplasmic shuttling. Isoform 3 contains a C-terminus domain with homology to Drosophila TIM (THD domain). Isoform 3 interacts with Per1 and specifically down-regulates its expression, probably by facilitating its recruitment to the proteasome. The interaction with PER1 depends on the presence of the THD domain, but the THD domain is not directly involved in the interaction. Isoform 3 is rapidly degraded by a proteasome-mediated degradation pathway. Mutant mice show defects in circadian gene expression and jet lag phenotype, but the master clock is not strongly affected. Per2 expression is rhythmic, but Per1 expression becomes nearly arrhythmic as well as Per1 target genes, such as Dbp. No splicing alteration was observed in the brain. Mutant mice show a faster adaptation to experimental jet lag, which is consistent with the circadian splicing switch providing a buffering system against sudden light changes. [Isoform 1]: Cytoplasmic and nuclear. Displays active nucleo-cytoplasmic shuttling. Shows a circadian expression at the mRNA level. [Isoform 2]: Produced by exon 7 skipping. Cytoplasm (PubMed:16819553). Shows a circadian expression at the mRNA level. [Isoform 3]: Produced by exons 6 and 7 skipping. Produced by a circadian splicing switch in brain and liver. Contains a C-terminus domain with homology to Drosophila TIM (THD). Cytoplasmic. Shows a circadian expression at the mRNA and protein levels. Expression is quickly increased upon light exposure. Has a strongly reduced half- life compared to other isoforms. [Isoform 4]: Produced by usage of an alternative 3' splice site in exon 8. Belongs to the splicing factor SR family. Orthologs of U2af1l4 do not appear to exist in lower eukaryotes, Drosophila, C. elegans, plants, or vertebrates such as Xenopus or zebrafish (PubMed:11739736). Existence of splicing isoforms of U2af1l4 in human and rat is not yet proven. mRNA splicing, via spliceosome nucleic acid binding RNA binding protein binding nucleus spliceosomal complex cytoplasm mRNA processing RNA splicing nuclear speck pre-mRNA 3'-splice site binding metal ion binding rhythmic process U2AF uc009gfa.1 uc009gfa.2 uc009gfa.3 
ENSMUST00000043285.5 Gm11992 ENSMUST00000043285.5 predicted gene 11992 (from RefSeq NM_001037928.3) CG057_MOUSE ENSMUST00000043285.1 ENSMUST00000043285.2 ENSMUST00000043285.3 ENSMUST00000043285.4 NM_001037928 Q5SS90 uc007hzv.1 uc007hzv.2 uc007hzv.3 molecular_function cellular_component biological_process uc007hzv.1 uc007hzv.2 uc007hzv.3 
ENSMUST00000043294.12 Asb4 ENSMUST00000043294.12 ankyrin repeat and SOCS box-containing 4, transcript variant 1 (from RefSeq NM_023048.5) ASB4_MOUSE ENSMUST00000043294.1 ENSMUST00000043294.10 ENSMUST00000043294.11 ENSMUST00000043294.2 ENSMUST00000043294.3 ENSMUST00000043294.4 ENSMUST00000043294.5 ENSMUST00000043294.6 ENSMUST00000043294.7 ENSMUST00000043294.8 ENSMUST00000043294.9 NM_023048 Q3UZE1 Q3V070 Q9WV71 uc009awi.1 uc009awi.2 uc009awi.3 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism. Protein modification; protein ubiquitination. Interacts with HIF1AN. Component of an ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex formed of CUL2 or CUL5, Elongin BC (ELOB and ELOC), RBX1 and ASB4. Highest expression detected in testis, with some expression detected in ovary and heart. Not detected in lung, kidney, liver, spleen and bone marrow. Differentially expressed in the vascular lineage during embryonic stem (ES) cell differentiation, with expression increasing when the cells differentiate. At 7.5 dpc, no remarkable expression is detected. At 9.5 dpc, expressed in intersomitic vessels, dorsal aorta, forelimb buds, allantois/umbilical vessels, vitelline vessels, septum transversum, proepicardium, capillary plexi of the head and branchial arches, endocardium, yolk sac vasculature and placenta. At 10.5 dpc, expressed in forelimb and hind limb buds, intersomitic vessels, peripheral liver cells and umbilical vessels, with expression in the capillary plexi of the head and branchial arches no longer detected. At 11.5 dpc, high expression levels are limited to forelimbs and hind limbs and the most caudal intersomitic vessels. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4 in promoting vascular differentiation. Belongs to the ankyrin SOCS box (ASB) family. ubiquitin-protein transferase activity protein ubiquitination enzyme binding Cul2-RING ubiquitin ligase complex Cul5-RING ubiquitin ligase complex ubiquitin protein ligase binding intracellular signal transduction protein autoubiquitination ubiquitin protein ligase activity positive regulation of vasculogenesis uc009awi.1 uc009awi.2 uc009awi.3 
ENSMUST00000043296.10 Dlgap5 ENSMUST00000043296.10 DLG associated protein 5, transcript variant 1 (from RefSeq NM_144553.3) A0A0R4J0G7 A0A0R4J0G7_MOUSE Dlgap5 ENSMUST00000043296.1 ENSMUST00000043296.2 ENSMUST00000043296.3 ENSMUST00000043296.4 ENSMUST00000043296.5 ENSMUST00000043296.6 ENSMUST00000043296.7 ENSMUST00000043296.8 ENSMUST00000043296.9 NM_144553 uc007tid.1 uc007tid.2 Belongs to the SAPAP family. phosphoprotein phosphatase activity nucleus mitochondrion microtubule organizing center cytosol protein dephosphorylation signaling spindle pole centrosome uc007tid.1 uc007tid.2 
ENSMUST00000043301.14 Aicda ENSMUST00000043301.14 activation-induced cytidine deaminase (from RefSeq NM_009645.2) AICDA_MOUSE Aid ENSMUST00000043301.1 ENSMUST00000043301.10 ENSMUST00000043301.11 ENSMUST00000043301.12 ENSMUST00000043301.13 ENSMUST00000043301.2 ENSMUST00000043301.3 ENSMUST00000043301.4 ENSMUST00000043301.5 ENSMUST00000043301.6 ENSMUST00000043301.7 ENSMUST00000043301.8 ENSMUST00000043301.9 NM_009645 Q9WVE0 uc009dpj.1 uc009dpj.2 uc009dpj.3 Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Reaction=a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O = a 2'- deoxyuridine in single-stranded DNA + NH4(+); Xref=Rhea:RHEA:50948, Rhea:RHEA-COMP:12846, Rhea:RHEA-COMP:12847, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:85452, ChEBI:CHEBI:133902; EC=3.5.4.38; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1 (By similarity). Interacts with SUPT6H, TRIM28 and NCL. Directly interacts with MCM3AP/GANP; this interaction may favor AICDA recruitment to immunoglobulin variable region genes, hence promoting somatic hypermutations (PubMed:20507984). Q9WVE0; Q91Z31: Ptbp2; NbExp=4; IntAct=EBI-3835567, EBI-647632; Q9WVE0; Q64511: Top2b; NbExp=3; IntAct=EBI-3835567, EBI-2325586; Q9WVE0; P24522: GADD45A; Xeno; NbExp=3; IntAct=EBI-3835567, EBI-448167; Nucleus Cytoplasm Note=Predominantly cytoplasmic. In the presence of MCM3AP/GANP, relocalizes to the nucleus. Expressed in germinal center B-cells (at protein level). Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity (By similarity). Probably monoubiquitinated on several residues by RNF126. Belongs to the cytidine and deoxycytidylate deaminase family. P-body RNA binding catalytic activity cytidine deaminase activity protein binding nucleus cytoplasm mRNA processing zinc ion binding cytidine deamination negative regulation of transposition somatic diversification of immunoglobulins somatic hypermutation of immunoglobulin genes cytidine to uridine editing hydrolase activity ubiquitin protein ligase binding macromolecular complex regulation of nuclear cell cycle DNA replication defense response to bacterium identical protein binding isotype switching negative regulation of single stranded viral RNA replication via double stranded DNA intermediate metal ion binding deoxycytidine deaminase activity defense response to virus DNA cytosine deamination cellular response to lipopolysaccharide DNA demethylation negative regulation of methylation-dependent chromatin silencing uc009dpj.1 uc009dpj.2 uc009dpj.3 
ENSMUST00000043305.14 Wdtc1 ENSMUST00000043305.14 WD and tetratricopeptide repeats 1, transcript variant 1 (from RefSeq NM_199306.4) ENSMUST00000043305.1 ENSMUST00000043305.10 ENSMUST00000043305.11 ENSMUST00000043305.12 ENSMUST00000043305.13 ENSMUST00000043305.2 ENSMUST00000043305.3 ENSMUST00000043305.4 ENSMUST00000043305.5 ENSMUST00000043305.6 ENSMUST00000043305.7 ENSMUST00000043305.8 ENSMUST00000043305.9 Gm695 NM_199306 Q80ZK9 WDTC1_MOUSE uc012dml.1 uc012dml.2 uc012dml.3 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Protein modification; protein ubiquitination. negative regulation of transcription from RNA polymerase II promoter in utero embryonic development enzyme inhibitor activity nucleus cytosol glucose metabolic process regulation of cell size protein ubiquitination cellular response to insulin stimulus multicellular organism growth histone binding histone deacetylase binding negative regulation of catalytic activity negative regulation of fatty acid biosynthetic process cellular chemical homeostasis uc012dml.1 uc012dml.2 uc012dml.3 
ENSMUST00000043311.7 Arhgap45 ENSMUST00000043311.7 Rho GTPase activating protein 45, transcript variant 2 (from RefSeq NM_027521.3) Arhgap45 ENSMUST00000043311.1 ENSMUST00000043311.2 ENSMUST00000043311.3 ENSMUST00000043311.4 ENSMUST00000043311.5 ENSMUST00000043311.6 HMHA1_MOUSE Hmha1 NM_027521 Q3TBD2 Q3TDD2 Q3TSW0 Q3TXM6 Q3UZ72 Q8BI83 Q9CU46 uc007gbg.1 uc007gbg.2 uc007gbg.3 uc007gbg.4 Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR- domin which is able to play an autoinhibitory effect on this RhoGAP activity. Cytoplasm Cell projection, ruffle membrane Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3TBD2-1; Sequence=Displayed; Name=2; IsoId=Q3TBD2-2; Sequence=VSP_033031, VSP_033032; Name=3; IsoId=Q3TBD2-3; Sequence=VSP_033030; Name=4; IsoId=Q3TBD2-4; Sequence=VSP_033029; Rho-GAP domain is able to regulate RhoGTPase activity, actin cytoskeleton and cell spreading. However N-terminally BAR domain plays an autoinhibitory role. molecular_function GTPase activator activity cytoplasm plasma membrane signal transduction membrane ruffle membrane intracellular signal transduction cell projection positive regulation of GTPase activity metal ion binding uc007gbg.1 uc007gbg.2 uc007gbg.3 uc007gbg.4 
ENSMUST00000043313.15 Nmnat2 ENSMUST00000043313.15 nicotinamide nucleotide adenylyltransferase 2, transcript variant 1 (from RefSeq NM_175460.4) ENSMUST00000043313.1 ENSMUST00000043313.10 ENSMUST00000043313.11 ENSMUST00000043313.12 ENSMUST00000043313.13 ENSMUST00000043313.14 ENSMUST00000043313.2 ENSMUST00000043313.3 ENSMUST00000043313.4 ENSMUST00000043313.5 ENSMUST00000043313.6 ENSMUST00000043313.7 ENSMUST00000043313.8 ENSMUST00000043313.9 Kiaa0479 NMNA2_MOUSE NM_175460 Nmnat2 Q8BNJ3 uc007czq.1 uc007czq.2 uc007czq.3 Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (PubMed:20126265, PubMed:23082226). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (PubMed:20126265, PubMed:23082226, PubMed:25818290). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (By similarity). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate (By similarity). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP- ribosylation of ribosomes by PARP16 (By similarity). Reaction=ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+); Xref=Rhea:RHEA:21360, ChEBI:CHEBI:14649, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57540; EC=2.7.7.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21361; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21362; Evidence=; Reaction=ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate; Xref=Rhea:RHEA:22860, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57502, ChEBI:CHEBI:58437; EC=2.7.7.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22861; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22862; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Divalent metal cations. Mg(2+) confers the highest activity. ; Inhibited by P1-(adenosine-5')-P3-(nicotinamide- riboside-5')-triphosphate (Np3AD) and P1-(adenosine-5')-P4- (nicotinamide-riboside-5')-tetraphosphate (Np4AD). Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. Monomer. Golgi apparatus membrane ; Lipid-anchor Cytoplasmic vesicle membrane; Lipid- anchor Cytoplasm Cell projection, axon Note=Delivered to axons with Golgi- derived cytoplasmic vesicles. Expressed predominantly in the brain and nervous system. Degraded in response to injured neurite (PubMed:20126265, PubMed:23665224, PubMed:23610559). Degradation is caused by polyubiquitination by MYCBP2 after recognition by FBXO45 (PubMed:23665224, PubMed:23610559). Palmitoylated; palmitoylation is required for membrane association. Perinatal lethality (PubMed:23082226). Mice show a greatly distended bladder, underdeveloped diaphragm and a reduction in total skeletal muscle mass (PubMed:23082226). Defects are caused by defects in innervation of major organs and tissues (PubMed:23082226). Mice lacking both Sarm1 and Nmnat2 are viable and survive: Sarm1 deficiency corrects axon outgrowth in mice lacking Nmnat2, independently of NMNAT metabolites, preventing perinatal lethality (PubMed:25818290). Belongs to the eukaryotic NMN adenylyltransferase family. Sequence=BAC97965.1; Type=Frameshift; Evidence=; Golgi membrane nucleotide binding nicotinamide-nucleotide adenylyltransferase activity catalytic activity nicotinate-nucleotide adenylyltransferase activity ATP binding cytoplasm late endosome Golgi apparatus trans-Golgi network biosynthetic process NAD biosynthetic process membrane transferase activity nucleotidyltransferase activity pyridine nucleotide biosynthetic process axon cytoplasmic vesicle membrane cytoplasmic vesicle cell projection synapse uc007czq.1 uc007czq.2 uc007czq.3 
ENSMUST00000043314.10 Cyp2s1 ENSMUST00000043314.10 cytochrome P450, family 2, subfamily s, polypeptide 1 (from RefSeq NM_028775.4) CP2S1_MOUSE ENSMUST00000043314.1 ENSMUST00000043314.2 ENSMUST00000043314.3 ENSMUST00000043314.4 ENSMUST00000043314.5 ENSMUST00000043314.6 ENSMUST00000043314.7 ENSMUST00000043314.8 ENSMUST00000043314.9 NM_028775 Q9DBX6 uc009fub.1 uc009fub.2 uc009fub.3 A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids. In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage. Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:55860, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:139183; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55861; Evidence=; Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51984, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134178; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51985; Evidence=; Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo- (6E,8Z,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48632, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:65342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48633; Evidence=; Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo- (5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37947, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37948; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo- (5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48637; Evidence=; Reaction=prostaglandin H2 = thromboxane A2; Xref=Rhea:RHEA:17137, ChEBI:CHEBI:57405, ChEBI:CHEBI:57445; EC=5.3.99.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17138; Evidence=; Reaction=prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)- heptadecatrienoate + malonaldehyde; Xref=Rhea:RHEA:48644, ChEBI:CHEBI:57405, ChEBI:CHEBI:90694, ChEBI:CHEBI:566274; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48645; Evidence=; Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)- octadecadienoate + H2O; Xref=Rhea:RHEA:48716, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:90781; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48717; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Lipid metabolism; fatty acid metabolism. Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. monooxygenase activity thromboxane-A synthase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process lipid metabolic process fatty acid metabolic process icosanoid metabolic process prostaglandin metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen lyase activity hydro-lyase activity isomerase activity epoxygenase P450 pathway heme binding organelle membrane retinoic acid metabolic process exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc009fub.1 uc009fub.2 uc009fub.3 
ENSMUST00000043315.15 Serpina3g ENSMUST00000043315.15 serine (or cysteine) peptidase inhibitor, clade A, member 3G, transcript variant 3 (from RefSeq NM_001353613.1) ENSMUST00000043315.1 ENSMUST00000043315.10 ENSMUST00000043315.11 ENSMUST00000043315.12 ENSMUST00000043315.13 ENSMUST00000043315.14 ENSMUST00000043315.2 ENSMUST00000043315.3 ENSMUST00000043315.4 ENSMUST00000043315.5 ENSMUST00000043315.6 ENSMUST00000043315.7 ENSMUST00000043315.8 ENSMUST00000043315.9 F2Z405 F2Z405_MOUSE NM_001353613 Serpina3g uc007oxa.1 uc007oxa.2 uc007oxa.3 uc007oxa.4 uc007oxa.5 Belongs to the serpin family. extracellular space uc007oxa.1 uc007oxa.2 uc007oxa.3 uc007oxa.4 uc007oxa.5 
ENSMUST00000043317.7 Dnajc12 ENSMUST00000043317.7 DnaJ heat shock protein family (Hsp40) member C12, transcript variant 1 (from RefSeq NM_013888.3) DJC12_MOUSE ENSMUST00000043317.1 ENSMUST00000043317.2 ENSMUST00000043317.3 ENSMUST00000043317.4 ENSMUST00000043317.5 ENSMUST00000043317.6 Jdp1 NM_013888 Q9R022 uc007fkg.1 uc007fkg.2 uc007fkg.3 uc007fkg.4 Interacts with HSPA8. Cytoplasm Ubiquitous. Highest levels of expression in kidney. cytoplasm biological_process uc007fkg.1 uc007fkg.2 uc007fkg.3 uc007fkg.4 
ENSMUST00000043325.9 Hs2st1 ENSMUST00000043325.9 heparan sulfate 2-O-sulfotransferase 1, transcript variant 2 (from RefSeq NM_011828.4) ENSMUST00000043325.1 ENSMUST00000043325.2 ENSMUST00000043325.3 ENSMUST00000043325.4 ENSMUST00000043325.5 ENSMUST00000043325.6 ENSMUST00000043325.7 ENSMUST00000043325.8 HS2ST_MOUSE Hs2st NM_011828 O88464 Q3TNP7 Q8R3H7 Q9JLK2 uc012cyx.1 uc012cyx.2 uc012cyx.3 Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand- binding interactions and signaling processes. Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues. Kinetic parameters: KM=3.7 uM for iduronic acid-containing substrate disaccharide units ; KM=19.3 uM for glucuronic acid-containing substrate disaccharide units ; Homotrimer (By similarity). Interacts with the C5-epimerase GLCE. Golgi apparatus membrane ; Single-pass type II membrane protein Widely expressed. Expressed at higher level in lung and brain. Weakly expressed in spleen. At 7.5 dpc, it is expressed in all three germ layers, although it appears to be more expressed in the embryonic ectoderm and the node. Widespread expression persists at 8.5 dpc, although it is clearly expressed at higher level in rhombomeres 2 and 4 and branchial arches 1 and 2 (which are populated by neural crest from these rhombomeres). At 10.5 dpc, the dorsal and ventral aspects of the neural tube, brain and midbrain-hindbrain junction show the most intense expression. A day later in development, elevated expression is found in the floor plate and the sclerotome. At 12.5 dpc, both the floor plate and the roofplate exhibit strong expression as the mesenchyme of the limb and of the developing whisker follicles. At 13.5 dpc, it is predominantly expressed in embryonic mesenchyme, especially at sites of epithelial-mesenchymal interactions such as the developing teeth and whisker follicles. Strong expression is also apparent in the perichondria of the cartilaginous skeleton, an important site for the regulation of skeletal differentiation. N-glycosylated. Mice die in the neonatal period, exhibiting bilateral renal agenesis and defects of the eye and the skeleton. Uronate 2-O-sulfates are not detected in such mice, however, the domain structure of the HS is conserved, due to a compensatory increase in N- and 6-O-sulfation maintain the overall charge density. Belongs to the sulfotransferase 3 family. Golgi membrane heparan sulfate 2-O-sulfotransferase activity Golgi apparatus sulfotransferase activity heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process heparan sulfate proteoglycan biosynthetic process, enzymatic modification membrane integral component of membrane transferase activity heparin metabolic process ureteric bud formation uc012cyx.1 uc012cyx.2 uc012cyx.3 
ENSMUST00000043336.11 St8sia4 ENSMUST00000043336.11 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4, transcript variant 6 (from RefSeq NR_185227.1) ENSMUST00000043336.1 ENSMUST00000043336.10 ENSMUST00000043336.2 ENSMUST00000043336.3 ENSMUST00000043336.4 ENSMUST00000043336.5 ENSMUST00000043336.6 ENSMUST00000043336.7 ENSMUST00000043336.8 ENSMUST00000043336.9 NR_185227 Pst Q64692 SIA8D_MOUSE Siat8d uc011wpu.1 uc011wpu.2 uc011wpu.3 Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells. Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Strongly expressed in lung, heart and spleen and weakly in brain. Expressed throughout development at a low level. Belongs to the glycosyltransferase 29 family. Name=Functional Glycomics Gateway - GTase; Note=ST8Sia IV; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_659"; Golgi membrane ganglioside biosynthetic process alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Golgi apparatus protein glycosylation N-glycan processing sialyltransferase activity oligosaccharide metabolic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups sialylation uc011wpu.1 uc011wpu.2 uc011wpu.3 
ENSMUST00000043338.10 Sft2d2 ENSMUST00000043338.10 SFT2 domain containing 2, transcript variant 3 (from RefSeq NR_151712.1) ENSMUST00000043338.1 ENSMUST00000043338.2 ENSMUST00000043338.3 ENSMUST00000043338.4 ENSMUST00000043338.5 ENSMUST00000043338.6 ENSMUST00000043338.7 ENSMUST00000043338.8 ENSMUST00000043338.9 NR_151712 Q8VD57 SFT2B_MOUSE Sft2d2 uc007dix.1 uc007dix.2 uc007dix.3 uc007dix.4 May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Membrane ; Multi-pass membrane protein Belongs to the SFT2 family. molecular_function protein transport membrane integral component of membrane vesicle-mediated transport uc007dix.1 uc007dix.2 uc007dix.3 uc007dix.4 
ENSMUST00000043349.7 Grid1 ENSMUST00000043349.7 glutamate receptor, ionotropic, delta 1 (from RefSeq NM_008166.2) ENSMUST00000043349.1 ENSMUST00000043349.2 ENSMUST00000043349.3 ENSMUST00000043349.4 ENSMUST00000043349.5 ENSMUST00000043349.6 GRID1_MOUSE NM_008166 Q3UUL5 Q61627 uc007tbj.1 uc007tbj.2 uc007tbj.3 Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Dimer (PubMed:27418511). Interacts (via extracellular N- terminal domain) with CBLN1 (via C1q domain), and more weakly with CBLN2 (PubMed:22220752, PubMed:27418511). Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi- pass membrane protein Equally in forebrain and cerebellum. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily. ionotropic glutamate receptor activity ion channel activity protein binding plasma membrane ion transport glutamate receptor activity ligand-gated ion channel activity membrane integral component of membrane cell junction ion transmembrane transport social behavior ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic signaling receptor activity synapse postsynaptic membrane modulation of synaptic transmission regulation of postsynaptic membrane potential postsynaptic density membrane glutamatergic synapse integral component of postsynaptic density membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc007tbj.1 uc007tbj.2 uc007tbj.3 
ENSMUST00000043352.8 Tmem156 ENSMUST00000043352.8 transmembrane protein 156 (from RefSeq NM_001370814.2) D3Z447 D3Z447_MOUSE ENSMUST00000043352.1 ENSMUST00000043352.2 ENSMUST00000043352.3 ENSMUST00000043352.4 ENSMUST00000043352.5 ENSMUST00000043352.6 ENSMUST00000043352.7 NM_001370814 Tmem156 uc290vup.1 uc290vup.2 molecular_function cellular_component biological_process membrane integral component of membrane uc290vup.1 uc290vup.2 
ENSMUST00000043359.9 Smarca5 ENSMUST00000043359.9 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (from RefSeq NM_053124.2) ENSMUST00000043359.1 ENSMUST00000043359.2 ENSMUST00000043359.3 ENSMUST00000043359.4 ENSMUST00000043359.5 ENSMUST00000043359.6 ENSMUST00000043359.7 ENSMUST00000043359.8 NM_053124 Q8C791 Q8CA22 Q8VDG1 Q91ZW3 Q925M9 SMCA5_MOUSE Snf2h uc009mja.1 uc009mja.2 uc009mja.3 uc009mja.4 Helicase that possesses intrinsic ATP-dependent nucleosome- remodeling activity (By similarity). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:11532953, PubMed:11980720, PubMed:12198165). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:11532953, PubMed:11980720, PubMed:12198165). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (By similarity). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:11532953, PubMed:11980720, PubMed:12198165). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (By similarity). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (By similarity). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (By similarity). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (PubMed:12198165). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (PubMed:19092802). Essential component of the NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (PubMed:11532953, PubMed:12198165, PubMed:12368916). Required for embryonic development and differentiation, and the proliferation of early blastocyst-derived stem cells (PubMed:14617767). Component of the ACF-5 ISWI chromatin-remodeling complex (also called the ACF/WCRF complex) at least composed of SMARCA5/SNF2H and BAZ1A/ACF1, which regulates the spacing of histone octamers on the DNA template to facilitate access to DNA (By similarity). Within the complex interacts with BAZ1A/ACF1; the interaction is direct and is required to slide nucleosomes from end to center positions on a DNA template in an ATP-dependent manner (By similarity). Component of the CHRAC ISWI chromatin-remodeling complex at least composed of SMARCA5/SNF2H, BAZ1A/ACF1, CHRAC1 and POLE3; the complex preferentially binds DNA through the CHRAC1-POLE3 heterodimer and possesses ATP- dependent nucleosome-remodeling activity (By similarity). Within the complex interacts with BAZ1A/ACF1; the interaction is direct and promotes the interaction with the POLE3-CHRAC1 heterodimer (By similarity). Within the complex interacts with the POLE3-CHRAC1 heterodimer; the interaction is direct and enhances nucleosome sliding activity by the SMARCA5/SNF2H and BAZ1A/ACF1 interaction (By similarity). Neither POLE3 nor CHRAC1 enhances nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (By similarity). Component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex) at least composed of SMARCA5/SNF2H and BAZ1B/WSTF, which regulates the spacing of histone octamers on the DNA template to facilitate access to DNA (PubMed:11980720). Within the complex interacts with BAZ1B/WSTF (PubMed:19092802). Component of the NoRC-5 ISWI chromatin-remodeling complex (also called the NoRC chromatin-remodeling complex) at least composed of SMARCA5/SNF2H and BAZ2A/TIP5; the complex suppresses rDNA transcription by a combination of nucleosome remodeling, histone deacetylation, and DNA methylation (PubMed:11532953, PubMed:12198165). Within the complex interacts with BAZ2A/TIP5 (PubMed:12198165). Within the complex interacts with HDAC1 (PubMed:12198165). Component of the BRF-5 ISWI chromatin-remodeling complex at least composed of SMARCA5/SNF2H and BAZ2B (By similarity). Within the complex interacts with BAZ2B (By similarity). Component of the NURF-5 ISWI chromatin-remodeling complex at least composed of SMARCA5/SNF2H and BPTF (By similarity). Within the complex interacts with BPFT (By similarity). Component of the CERF-5 ISWI chromatin- remodeling complex at least composed of SMARCA5/SNF2H and CECR2 (By similarity). Within the complex interacts with CECR2 (By similarity). Component of the RSF-5 ISWI chromatin-remodeling complex (also called the RSF complex) at least composed of SMARCA5/SNF2H and RSF1 (By similarity). Within the complex interacts with RSF1 (By similarity). Interacts with the cohesin complex component RAD21; the interaction is direct (By similarity). Interacts with the NuRD complex components HDAC2, RBBP4 and CHD4; the interactions are direct (By similarity). Interacts with PCNA (By similarity). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 which positively regulates RNA polymerase III transcription (By similarity). Interacts with MYO1C (PubMed:16514417). Interacts with BEND3 (By similarity). Interacts with SIRT6; promoting recruitment to DNA damage sites (By similarity). Q91ZW3; Q9Z277: Baz1b; NbExp=2; IntAct=EBI-927547, EBI-927576; Q91ZW3; P54843: Maf; NbExp=2; IntAct=EBI-927547, EBI-3842521; Nucleus romosome Note=Localizes to mitotic chromosomes. Co-localizes with RSF1 in the nucleus. Co-localizes with PCNA at replication foci during S phase. Co-localizes with BAZ1B/WSTF at replication foci during late-S phase. Recruited to DNA damage sites following interactiuon with SIRT6. Ubiquitously expressed. Expressed in CD34-positive erythrocyte progenitor cells. Down-regulated upon differentiation. Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. Sequence=AAH21922.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding chromatin silencing at rDNA condensed chromosome fibrillar center nucleic acid binding DNA binding helicase activity protein binding ATP binding nucleus nucleoplasm chromatin silencing complex chromatin organization chromatin assembly or disassembly nucleosome assembly chromatin remodeling DNA-templated transcription, initiation DNA-dependent ATPase activity nucleosome positioning NURF complex hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ATPase activity ISWI-type complex RSF complex nucleosome binding histone binding ATP-dependent chromatin remodeling nuclear replication fork positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cellular response to leukemia inhibitory factor uc009mja.1 uc009mja.2 uc009mja.3 uc009mja.4 
ENSMUST00000043374.7 Ppp1r14c ENSMUST00000043374.7 protein phosphatase 1, regulatory inhibitor subunit 14C (from RefSeq NM_133485.2) ENSMUST00000043374.1 ENSMUST00000043374.2 ENSMUST00000043374.3 ENSMUST00000043374.4 ENSMUST00000043374.5 ENSMUST00000043374.6 Kepi NM_133485 PP14C_MOUSE Q8R4S0 uc007ehq.1 uc007ehq.2 uc007ehq.3 Inhibitor of the PP1 regulatory subunit PPP1CA. Endomembrane system ; Peripheral membrane protein Detected in heart, muscle, spinal cord, hippocampus, hypothalamus, thalamus, midbrain, brain stem, cerebellum, brain cortex and olfactory bulb. Up-regulated by morphine. The main inhibitory site appears to be Thr-72 (By similarity). Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Belongs to the PP1 inhibitor family. protein phosphatase inhibitor activity protein serine/threonine phosphatase inhibitor activity cytoplasm signal transduction endomembrane system membrane negative regulation of phosphoprotein phosphatase activity regulation of phosphorylation uc007ehq.1 uc007ehq.2 uc007ehq.3 
ENSMUST00000043378.9 Tmem120a ENSMUST00000043378.9 transmembrane protein 120A (from RefSeq NM_172541.2) ENSMUST00000043378.1 ENSMUST00000043378.2 ENSMUST00000043378.3 ENSMUST00000043378.4 ENSMUST00000043378.5 ENSMUST00000043378.6 ENSMUST00000043378.7 ENSMUST00000043378.8 NM_172541 Net29 Q8BWP7 Q8C1E7 TACAN_MOUSE Tacan Tmem120a uc008zyu.1 uc008zyu.2 uc008zyu.3 Ion channel involved in sensing mechanical pain (PubMed:32084332). Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli (PubMed:32084332). May also be required for efficient adipogenesis (PubMed:26024229). Homooligomer and heterooligomer with TMEM120B. Cell membrane ; Multi-pass membrane protein Nucleus inner membrane ; Multi-pass membrane protein Widely expressed, with higher expression in the heart, kidneys, colon and sensory neurons of the dorsal root ganglia (PubMed:32084332). Expressed in nociceptors (PubMed:32084332). Highly expressed in white adipose tissue (at protein level) (PubMed:26024229). Highly expressed in brown adipose tissue and expressed at low levels in liver (PubMed:26024229). Up-regulated during adipocyte differentiation. Embryonic lethality (PubMed:32084332). Conditional knockout in nociceptors decreases the mechanosensitivity of nociceptors and reduces behavioral responses to painful mechanical stimuli but not to thermal or touch stimuli (PubMed:32084332). TACAN means movement in Farsi. Belongs to the TMEM120 family. molecular_function nucleus nuclear inner membrane membrane integral component of membrane fat cell differentiation protein homooligomerization protein heterooligomerization uc008zyu.1 uc008zyu.2 uc008zyu.3 
ENSMUST00000043379.5 Cysrt1 ENSMUST00000043379.5 cysteine rich tail 1 (from RefSeq NM_026415.4) CRTP1_MOUSE ENSMUST00000043379.1 ENSMUST00000043379.2 ENSMUST00000043379.3 ENSMUST00000043379.4 NM_026415 Q9D1E4 Q9D7M7 uc008iqv.1 uc008iqv.2 uc008iqv.3 uc008iqv.4 Component of the stratum corneum that may contribute to epidermal antimicrobial host defenses. Interacts with components of the late cornfied envelope (LCE). Cornified envelope Belongs to the CYSRT1 family. molecular_function biological_process uc008iqv.1 uc008iqv.2 uc008iqv.3 uc008iqv.4 
ENSMUST00000043380.5 Catsper1 ENSMUST00000043380.5 cation channel, sperm associated 1 (from RefSeq NM_139301.3) CTSR1_MOUSE ENSMUST00000043380.1 ENSMUST00000043380.2 ENSMUST00000043380.3 ENSMUST00000043380.4 NM_139301 Q4PZC3 Q4PZC4 Q4PZC5 Q4PZC6 Q4PZD2 Q91ZR5 uc008gcp.1 uc008gcp.2 uc008gcp.3 Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. In contrast to the human ortholog, not activated by progesterone. Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG2, CATSPERD, CATSPERE, CATSPERZ, C2CD6/CATSPERT, SLCO6C1, TMEM249, TMEM262 and EFCAB9 (PubMed:34225353, PubMed:21224844, PubMed:17478420, PubMed:19516020, PubMed:17227845, PubMed:34998468). HSPA1 may be an additional auxiliary complex member (PubMed:17478420, PubMed:19516020). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (PubMed:34225353). The auxiliary CATSPERB, CATSPERG2, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively (PubMed:34225353). SLCO6C1 interacts with CATSPERE, and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex (PubMed:34225353). C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane (PubMed:34998468). Interacts with Ca(v)3.3/CACNA1I, leading to suppression of T-type calcium channel activity (By similarity). Q91ZR5; Q80W99: Catsper3; NbExp=2; IntAct=EBI-15619083, EBI-15619135; Q91ZR5; Q8BVN3: Catsper4; NbExp=2; IntAct=EBI-15619083, EBI-15619199; Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein Note=Specifically located in the principal piece of the sperm tail. Testis-specific. Detected only after round spermatids are produced approximately at day 18. Mice are normal but males are sterile. Male sterility is due to defects in sperm motility unability to fertilize intact eggs. In mice lacking Catsper1, sperm lacks CatSper2 protein, while in mice lacking CatSper1, sperm lacks CatSper1 protein, suggesting that stable expression of CatSper1 protein requires CatSper2 and vice versa. Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. ion channel activity calcium activated cation channel activity voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity protein binding plasma membrane cilium ion transport calcium ion transport multicellular organism development spermatogenesis fusion of sperm to egg plasma membrane membrane integral component of membrane cell differentiation flagellated sperm motility motile cilium regulation of ion transmembrane transport CatSper complex cell projection regulation of calcium ion transport transmembrane transport regulation of cilium beat frequency involved in ciliary motility calcium ion transmembrane transport uc008gcp.1 uc008gcp.2 uc008gcp.3 
ENSMUST00000043382.9 4930544G11Rik ENSMUST00000043382.9 RIKEN cDNA 4930544G11 gene (from RefSeq NM_001161773.1) 4930544G11Rik ENSMUST00000043382.1 ENSMUST00000043382.2 ENSMUST00000043382.3 ENSMUST00000043382.4 ENSMUST00000043382.5 ENSMUST00000043382.6 ENSMUST00000043382.7 ENSMUST00000043382.8 NM_001161773 Q9CR99 Q9CR99_MOUSE uc009cem.1 uc009cem.2 uc009cem.3 uc009cem.4 nucleotide binding GTPase activity GTP binding cytoplasm cell cortex actin filament organization small GTPase mediated signal transduction Rho protein signal transduction regulation of cell shape cell migration protein kinase binding regulation of cell migration establishment or maintenance of actin cytoskeleton polarity cell division site regulation of actin cytoskeleton organization stress fiber assembly dendritic spine intracellular membrane-bounded organelle actin filament bundle assembly plasma membrane cleavage furrow uc009cem.1 uc009cem.2 uc009cem.3 uc009cem.4 
ENSMUST00000043396.15 Mycn ENSMUST00000043396.15 v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (from RefSeq NM_008709.3) ENSMUST00000043396.1 ENSMUST00000043396.10 ENSMUST00000043396.11 ENSMUST00000043396.12 ENSMUST00000043396.13 ENSMUST00000043396.14 ENSMUST00000043396.2 ENSMUST00000043396.3 ENSMUST00000043396.4 ENSMUST00000043396.5 ENSMUST00000043396.6 ENSMUST00000043396.7 ENSMUST00000043396.8 ENSMUST00000043396.9 Mycn NM_008709 Q3UII1 Q3UII1_MOUSE uc007nbg.1 uc007nbg.2 uc007nbg.3 uc007nbg.4 Efficient DNA binding requires dimerization with another bHLH protein. Nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated protein dimerization activity uc007nbg.1 uc007nbg.2 uc007nbg.3 uc007nbg.4 
ENSMUST00000043397.14 Plekhh3 ENSMUST00000043397.14 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3, transcript variant 1 (from RefSeq NM_146030.2) ENSMUST00000043397.1 ENSMUST00000043397.10 ENSMUST00000043397.11 ENSMUST00000043397.12 ENSMUST00000043397.13 ENSMUST00000043397.2 ENSMUST00000043397.3 ENSMUST00000043397.4 ENSMUST00000043397.5 ENSMUST00000043397.6 ENSMUST00000043397.7 ENSMUST00000043397.8 ENSMUST00000043397.9 NM_146030 PKHH3_MOUSE Q3U3Z6 Q8R1H2 Q8VCE9 uc007lnq.1 uc007lnq.2 uc007lnq.3 uc007lnq.4 uc007lnq.5 Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8VCE9-1; Sequence=Displayed; Name=2; IsoId=Q8VCE9-2; Sequence=VSP_029399; Name=3; IsoId=Q8VCE9-3; Sequence=VSP_029399, VSP_029400, VSP_029401; Name=4; IsoId=Q8VCE9-4; Sequence=VSP_029400, VSP_029401; molecular_function cytoskeleton signal transduction biological_process uc007lnq.1 uc007lnq.2 uc007lnq.3 uc007lnq.4 uc007lnq.5 
ENSMUST00000043400.9 Asprv1 ENSMUST00000043400.9 aspartic peptidase, retroviral-like 1 (from RefSeq NM_026414.3) A0A8D3UE05 A0A8D3UE05_MOUSE Asprv1 ENSMUST00000043400.1 ENSMUST00000043400.2 ENSMUST00000043400.3 ENSMUST00000043400.4 ENSMUST00000043400.5 ENSMUST00000043400.6 ENSMUST00000043400.7 ENSMUST00000043400.8 NM_026414 uc009csf.1 uc009csf.2 uc009csf.3 uc009csf.4 uc009csf.1 uc009csf.2 uc009csf.3 uc009csf.4 
ENSMUST00000043409.9 Zfp503 ENSMUST00000043409.9 zinc finger protein 503 (from RefSeq NM_145459.3) ENSMUST00000043409.1 ENSMUST00000043409.2 ENSMUST00000043409.3 ENSMUST00000043409.4 ENSMUST00000043409.5 ENSMUST00000043409.6 ENSMUST00000043409.7 ENSMUST00000043409.8 NM_145459 Nolz1 Q7TMA2 Q8VCV4 ZN503_MOUSE Znf503 uc007slv.1 uc007slv.2 uc007slv.3 May function as a transcriptional repressor. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TMA2-1; Sequence=Displayed; Name=2; IsoId=Q7TMA2-2; Sequence=VSP_026396, VSP_026397, VSP_026398; Belongs to the Elbow/Noc family. nucleic acid binding nucleus negative regulation of cell proliferation negative regulation of gene expression metal ion binding neural precursor cell proliferation G1 to G0 transition involved in cell differentiation uc007slv.1 uc007slv.2 uc007slv.3 
ENSMUST00000043414.12 Dennd3 ENSMUST00000043414.12 DENN domain containing 3, transcript variant 1 (from RefSeq NM_001081066.2) A2RT67 B2RQ75 DEND3_MOUSE ENSMUST00000043414.1 ENSMUST00000043414.10 ENSMUST00000043414.11 ENSMUST00000043414.2 ENSMUST00000043414.3 ENSMUST00000043414.4 ENSMUST00000043414.5 ENSMUST00000043414.6 ENSMUST00000043414.7 ENSMUST00000043414.8 ENSMUST00000043414.9 Kiaa0870 NM_001081066 Q69ZX2 Q8C6V5 uc007wce.1 uc007wce.2 Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation (PubMed:24719330, PubMed:25925668, PubMed:28249939). Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12 (PubMed:25925668). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:21718402, PubMed:24719330). Starvation also induces phosphorylation at Tyr-940, which leads to up- regulated GEF activity and initiates autophagy (PubMed:28249939). Forms oligomers (PubMed:28249939). Interacts with 6 of the 7 known isoforms of 14-3-3 proteins (PubMed:25925668). Cytoplasm Note=Transiently recruited to membranes to activate Rab12. Inactive Dennd3 is found in a closed conformation, in which the linker region interacts with the DENN domain. Phosphorylation of Tyr- 940 in the linker region intereferes with this interaction leading to an open conformation and enhances the GEF activity of the protein towards Rab12. Sequence=BAC35269.1; Type=Erroneous initiation; Evidence=; Sequence=BAD32324.1; Type=Erroneous initiation; Evidence=; guanyl-nucleotide exchange factor activity cytoplasm endosome to lysosome transport Rab guanyl-nucleotide exchange factor activity cellular protein catabolic process uc007wce.1 uc007wce.2 
ENSMUST00000043415.13 Tekt5 ENSMUST00000043415.13 tektin 5 (from RefSeq NM_001291001.2) D5HP88 ENSMUST00000043415.1 ENSMUST00000043415.10 ENSMUST00000043415.11 ENSMUST00000043415.12 ENSMUST00000043415.2 ENSMUST00000043415.3 ENSMUST00000043415.4 ENSMUST00000043415.5 ENSMUST00000043415.6 ENSMUST00000043415.7 ENSMUST00000043415.8 ENSMUST00000043415.9 G5E8A8 NM_001291001 Q14BE9 TEKT5_MOUSE Tekt5 uc007ydl.1 uc007ydl.2 uc007ydl.3 uc007ydl.4 uc007ydl.5 May be a structural component of the sperm flagellum. Interacts with TEKT3. Cell projection, cilium, flagellum Note=Appears to be associated with flagellar accessory structures and not the axoneme. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=G5E8A8-1; Sequence=Displayed; Name=2; IsoId=G5E8A8-2; Sequence=VSP_058377; Strongly expressed in germ cells of the testis (at protein level) (PubMed:20378928). Expressed in spermatozoa (PubMed:36708031). Also detected in brain (PubMed:20378928). In germ cells, has highest expression levels during late spermiogenesis (in round spermatids and condensing spermatids). Belongs to the tektin family. molecular_function cilium microtubule cytoskeleton motile cilium sperm flagellum cell projection cilium assembly cilium movement involved in cell motility uc007ydl.1 uc007ydl.2 uc007ydl.3 uc007ydl.4 uc007ydl.5 
ENSMUST00000043422.8 Tapbpl ENSMUST00000043422.8 TAP binding protein-like (from RefSeq NM_145391.2) E9QN33 ENSMUST00000043422.1 ENSMUST00000043422.2 ENSMUST00000043422.3 ENSMUST00000043422.4 ENSMUST00000043422.5 ENSMUST00000043422.6 ENSMUST00000043422.7 NM_145391 Q8VD31 TPSNR_MOUSE uc009dua.1 uc009dua.2 uc009dua.3 uc009dua.4 Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. Cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Microsome membrane ; Single-pass type I membrane protein Golgi apparatus membrane ; Single-pass type I membrane protein Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface. Widely expressed. Golgi membrane immune system process peptide antigen assembly with MHC class I protein complex negative regulation of antigen processing and presentation of peptide antigen via MHC class I cellular_component endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane membrane integral component of membrane MHC class I protein complex binding organelle membrane intracellular membrane-bounded organelle macromolecular complex binding uc009dua.1 uc009dua.2 uc009dua.3 uc009dua.4 
ENSMUST00000043437.14 Fchsd1 ENSMUST00000043437.14 FCH and double SH3 domains 1, transcript variant 1 (from RefSeq NM_175684.5) ENSMUST00000043437.1 ENSMUST00000043437.10 ENSMUST00000043437.11 ENSMUST00000043437.12 ENSMUST00000043437.13 ENSMUST00000043437.2 ENSMUST00000043437.3 ENSMUST00000043437.4 ENSMUST00000043437.5 ENSMUST00000043437.6 ENSMUST00000043437.7 ENSMUST00000043437.8 ENSMUST00000043437.9 FCSD1_MOUSE NM_175684 Q6PFY1 Q8BV86 uc008ero.1 uc008ero.2 uc008ero.3 Promotes actin polymerization mediated by SNX9 and WASL. Homodimer (Probable). Interacts (via F-BAR domain) with SNX9 (via SH3 domain) (PubMed:23437151, PubMed:26567222). Interacts (via F- BAR domain) with SNX18 and SNX33 (PubMed:26567222). Interacts (via SH3 domain 1) with WASL (PubMed:29887380). Interacts (via SH3 domain 2) with ITSN1 (PubMed:29887380). Cytoplasm rikaryon Cell projection Cytoplasmic vesicle Note=Detected on neuronal cell bodies and cell projections, in part on cytoplasmic vesicles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PFY1-1; Sequence=Displayed; Name=2; IsoId=Q6PFY1-2; Sequence=VSP_023166; Detected in inner ear vestibula and in the cuticular plate of cochlear hair cells (at protein level). Ubiquitous. Detected in testis, liver, brain cortex, cerebellum, spiral ganglion and tongue, and at lower levels in the organ of Corti and utricle in the inner ear. Detected in brain cortex at 15.5 dpc. Highly expressed in brain cortex from young and adult animals (at protein level). The F-BAR domain has an atypical, flat shape and binds preferentially to flat membranes (By similarity). Upon heterologous expression, the isolated F-BAR domain is localized at the cell membrane, and causes the formation of cellular protrusions (PubMed:23761074, PubMed:26567222). molecular_function cytoplasm neuromuscular synaptic transmission lipid binding regulation of actin filament polymerization positive regulation of actin filament polymerization cytoplasmic vesicle neuromuscular junction cell projection perikaryon multi-organism membrane organization recycling endosome cuticular plate uc008ero.1 uc008ero.2 uc008ero.3 
ENSMUST00000043456.12 Pakap ENSMUST00000043456.12 paralemmin A kinase anchor protein, transcript variant 1 (from RefSeq NM_001035533.2) A2APJ4 AKAP2_MOUSE Akap2 ENSMUST00000043456.1 ENSMUST00000043456.10 ENSMUST00000043456.11 ENSMUST00000043456.2 ENSMUST00000043456.3 ENSMUST00000043456.4 ENSMUST00000043456.5 ENSMUST00000043456.6 ENSMUST00000043456.7 ENSMUST00000043456.8 ENSMUST00000043456.9 NM_001035533 O54931 O54932 O54933 Pakap Palm2 Palm2akap2 Q8BR92 Q8C5W1 uc008syl.1 uc008syl.2 uc008syl.3 uc008syl.4 This locus represents naturally occurring readthrough transcription between the neighboring Palm2 (paralemmin 2) and Akap2 (A kinase (PRKA) anchor protein 2) genes on chromosome 4. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Similar readthrough transcription has also been observed in human, as described in PMID: 11478809. [provided by RefSeq, Feb 2015]. Binds to regulatory subunit (RII) of protein kinase A (PubMed:9497389). May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (PubMed:9497389). Binds tp and modulates the structure of the actin cytoskeleton (PubMed:9497389). O54931-3; P12367: Prkar2a; NbExp=3; IntAct=EBI-645828, EBI-645747; Apical cell membrane ; Lipid-anchor, GPI-like-anchor ; Cytoplasmic side Note=Accumulates near the inner, apical surface of highly polarized epithelium in tubules of nephrons. Event=Alternative splicing, Alternative initiation; Named isoforms=7; Name=6; IsoId=O54931-6; Sequence=Displayed; Name=1; Synonyms=KL1A; IsoId=O54931-1; Sequence=VSP_062024; Name=2; Synonyms=KL2A; IsoId=O54931-2; Sequence=VSP_062024, VSP_062029; Name=3; Synonyms=KL3A; IsoId=O54931-3; Sequence=VSP_062024, VSP_062027, VSP_062028; Name=4; Synonyms=KL1B; IsoId=O54931-4; Sequence=VSP_062023; Name=5; Synonyms=KL2B; IsoId=O54931-5; Sequence=VSP_062023, VSP_062029; Name=7; Synonyms=Palm2, Paralemmin-2; IsoId=O54931-7; Sequence=VSP_062025, VSP_062026; Highly expressed in lung and weakly in thymus and cerebellum (PubMed:9497389). Little or no expression in liver, heart and cerebral cortex (PubMed:9497389). All isoforms are expressed in lung, but KL2A and KL2B isoforms are the principal isoforms in cerebellum (PubMed:9497389). The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. [Isoform 2]: Produced by alternative splicing. [Isoform 3]: Produced by alternative splicing. [Isoform 4]: Produced by alternative initiation at Met- 321 of isoform KL1A. [Isoform 5]: Produced by alternative initiation at Met- 321 of isoform KL2A. Sequence=AAC02206.1; Type=Frameshift; Evidence=; Sequence=AAC02207.1; Type=Frameshift; Evidence=; protein binding uc008syl.1 uc008syl.2 uc008syl.3 uc008syl.4 
ENSMUST00000043458.9 Srd5a2 ENSMUST00000043458.9 steroid 5 alpha-reductase 2 (from RefSeq NM_053188.3) 5art2 ENSMUST00000043458.1 ENSMUST00000043458.2 ENSMUST00000043458.3 ENSMUST00000043458.4 ENSMUST00000043458.5 ENSMUST00000043458.6 ENSMUST00000043458.7 ENSMUST00000043458.8 NM_053188 Q3UTZ9 Q99N99 S5A2_MOUSE uc008dnt.1 uc008dnt.2 uc008dnt.3 Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Reaction=a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH; Xref=Rhea:RHEA:54384, ChEBI:CHEBI:13601, ChEBI:CHEBI:15378, ChEBI:CHEBI:47909, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.22; Evidence=; Reaction=17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = H(+) + NADPH + testosterone; Xref=Rhea:RHEA:50820, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:17347, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.22; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50822; Evidence=; Reaction=5alpha-pregnane-3,20-dione + NADP(+) = H(+) + NADPH + progesterone; Xref=Rhea:RHEA:21952, ChEBI:CHEBI:15378, ChEBI:CHEBI:17026, ChEBI:CHEBI:28952, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.22; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21954; Evidence=; Microsome membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the steroid 5-alpha reductase family. 3-oxo-5-alpha-steroid 4-dehydrogenase activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process androgen biosynthetic process steroid catabolic process sex differentiation steroid metabolic process androgen metabolic process male gonad development sterol 5-alpha reductase activity response to organic substance response to organic cyclic compound membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors biphenyl metabolic process dibenzo-p-dioxin metabolic process phthalate metabolic process hippocampus development hypothalamus development cell differentiation testosterone dehydrogenase [NAD(P)] activity male genitalia development female genitalia development organelle membrane response to nutrient levels response to follicle-stimulating hormone amide binding response to testosterone response to drug neuronal cell body intracellular membrane-bounded organelle response to peptide hormone cholestenone 5-alpha-reductase activity response to steroid hormone oxidation-reduction process bone development testosterone biosynthetic process cell body fiber uc008dnt.1 uc008dnt.2 uc008dnt.3 
ENSMUST00000043464.14 Cul7 ENSMUST00000043464.14 cullin 7 (from RefSeq NM_025611.5) CUL7_MOUSE ENSMUST00000043464.1 ENSMUST00000043464.10 ENSMUST00000043464.11 ENSMUST00000043464.12 ENSMUST00000043464.13 ENSMUST00000043464.2 ENSMUST00000043464.3 ENSMUST00000043464.4 ENSMUST00000043464.5 ENSMUST00000043464.6 ENSMUST00000043464.7 ENSMUST00000043464.8 ENSMUST00000043464.9 Kiaa0076 NM_025611 Q3UHY3 Q497I2 Q6A0D6 Q6PB63 Q8R3W4 Q8VE73 Q9CVD5 uc008ctp.1 uc008ctp.2 uc008ctp.3 Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin- protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1. Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Acts as a regulator in trophoblast cell epithelial- mesenchymal transition and placental development. Does not promote polyubiquitination and proteasomal degradation of p53/TP53. While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions (By similarity). Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. Protein modification; protein ubiquitination. Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. Part of a Cul7-RING complex consisting of CUL7, RBX1, SKP1 and FBXW8. Interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone. Interacts with CUL9; leading to inhibit CUL9 activity. Interacts with FBXW8; interaction is mutually exclusive of binding to CUL9 or p53/TP53. Interacts with p53/TP53; the interaction preferentially involves tetrameric and dimeric p53/TP53. The CUL7-CUL9 heterodimer seems to interact specifically with p53/TP53. Interacts with OBSL1 (By similarity). Interacts with CUL1; the interactions seems to be mediated by FBXW8. Interacts (as part of the 3M complex) with HDAC4 and HDAC5; it is negatively regulated by ANKRA2 (By similarity). Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, perinuclear region Golgi apparatus Note=Colocalizes with FBXW8 at the Golgi apparatus in neurons; localization to Golgi is mediated by OBSL1. During mitosis, localizes to the mitotic apparatus. CCDC8 is required for centrosomal location (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VE73-1; Sequence=Displayed; Name=2; IsoId=Q8VE73-3; Sequence=VSP_038331; Mice are neonatal lethal and show vascular defects in both the embryo and the placenta. Belongs to the cullin family. microtubule cytoskeleton organization mitotic cytokinesis vasculogenesis epithelial to mesenchymal transition placenta development protein binding cytoplasm Golgi apparatus centrosome microtubule organizing center cytoskeleton ubiquitin-dependent protein catabolic process apoptotic process Golgi organization regulation of mitotic nuclear division protein ubiquitination cullin-RING ubiquitin ligase complex Cul7-RING ubiquitin ligase complex ubiquitin protein ligase binding regulation of apoptotic process regulation of endothelial cell differentiation perinuclear region of cytoplasm positive regulation of dendrite morphogenesis 3M complex uc008ctp.1 uc008ctp.2 uc008ctp.3 
ENSMUST00000043484.8 Reep2 ENSMUST00000043484.8 receptor accessory protein 2, transcript variant 1 (from RefSeq NM_144865.2) ENSMUST00000043484.1 ENSMUST00000043484.2 ENSMUST00000043484.3 ENSMUST00000043484.4 ENSMUST00000043484.5 ENSMUST00000043484.6 ENSMUST00000043484.7 NM_144865 Q8VCD6 REEP2_MOUSE uc008elr.1 uc008elr.2 uc008elr.3 Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity). Interacts with odorant receptor proteins. Membrane ; Multi-pass membrane protein Belongs to the DP1 family. endoplasmic reticulum endoplasmic reticulum membrane cytoplasmic microtubule integral component of plasma membrane membrane integral component of membrane taste receptor binding regulation of intracellular transport protein transport into membrane raft sensory perception of bitter taste sensory perception of sweet taste endoplasmic reticulum tubular network organization plasma membrane uc008elr.1 uc008elr.2 uc008elr.3 
ENSMUST00000043493.7 Ice1 ENSMUST00000043493.7 interactor of little elongation complex ELL subunit 1 (from RefSeq NM_144837.3) E9Q286 ENSMUST00000043493.1 ENSMUST00000043493.2 ENSMUST00000043493.3 ENSMUST00000043493.4 ENSMUST00000043493.5 ENSMUST00000043493.6 ICE1_MOUSE Kiaa0947 NM_144837 Q6ZQ20 uc033gmk.1 uc033gmk.2 uc033gmk.3 Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (By similarity). Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts (via N-terminus domain) with ELL. Interacts (via C-terminus domain) with ICE2 and ZC3H8 (By similarity). Nucleus Nucleus, Cajal body Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Associates to transcriptionally active chromatin at snRNA genes. The N-termimus domain is necessary and sufficient for its targeting to subnuclear cajal and histone locus bodies. Belongs to the ICE1 family. molecular_function nucleus nucleoplasm transcription elongation factor complex Cajal body nuclear body positive regulation of protein complex assembly transcriptionally active chromatin histone locus body snRNA transcription from RNA polymerase II promoter snRNA transcription from RNA polymerase III promoter positive regulation of transcription from RNA polymerase III promoter positive regulation of intracellular protein transport uc033gmk.1 uc033gmk.2 uc033gmk.3 
ENSMUST00000043498.9 Hdac3 ENSMUST00000043498.9 histone deacetylase 3 (from RefSeq NM_010411.2) ENSMUST00000043498.1 ENSMUST00000043498.2 ENSMUST00000043498.3 ENSMUST00000043498.4 ENSMUST00000043498.5 ENSMUST00000043498.6 ENSMUST00000043498.7 ENSMUST00000043498.8 HDAC3_MOUSE Hdac3 NM_010411 O88895 O88896 Q3UM33 uc008erl.1 uc008erl.2 uc008erl.3 uc008erl.4 Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates (PubMed:23911289, PubMed:30279482). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:23911289). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:23911289). Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression (PubMed:23911289). Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:19204783). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (By similarity). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity- independent manner (PubMed:26776516). During the activation phase, promotes the accumulation of ubiquitinated BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and BMAL1 (PubMed:26776516). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene BMAL1 and the genes involved in lipid metabolism in the liver (PubMed:19037247). Also functions as deacetylase for non-histone targets, such as KAT5, MEF2D, MAPK14 and RARA (By similarity). Serves as a corepressor of RARA, mediating its deacetylation and repression, leading to inhibition of RARE DNA element binding (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity). In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2- hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively (PubMed:30279482). Catalyzes decrotonylation of MAPRE1/EB1 (By similarity). Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA- COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58197; Evidence=; Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl- [protein]; Xref=Rhea:RHEA:58108, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58109; Evidence=; Reaction=H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]; Xref=Rhea:RHEA:69172, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13707, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:35899, ChEBI:CHEBI:137954; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69173; Evidence=; Reaction=H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2- hydroxy-2-methylpropanoate + L-lysyl-[protein]; Xref=Rhea:RHEA:69176, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:15921, ChEBI:CHEBI:15377, ChEBI:CHEBI:19641, ChEBI:CHEBI:29969, ChEBI:CHEBI:144968; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69177; Evidence=; Interacts with HDAC7 and HDAC9 (PubMed:10984530, PubMed:11022042, PubMed:15711539). Interacts with DAXX, KDM4A, HDAC10 and DACH1 (PubMed:12130660). Found in a complex with NCOR1 and NCOR2 (By similarity). Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (By similarity). Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY (PubMed:16537907). Interacts with BTBD14B (By similarity). Interacts with GLIS2 (PubMed:16326862). Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:19204783). Component of the Notch corepressor complex (By similarity). Interacts with CBFA2T3 and NKAP (PubMed:11533236). Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1 (By similarity). Interacts with ZMYND15 (PubMed:20675388). Interacts with SMRT/NCOR2 and BCL6 on DNA enhancer elements (By similarity). Interacts with INSM1 (By similarity). Interacts with XBP1 isoform 1; the interaction occurs in endothelial cell (EC) under disturbed flow (By similarity). Interacts (via C-terminus) with CCAR2 (via N-terminus) (By similarity). Interacts with and deacetylates MEF2D (By similarity). Interacts with BEND3 (By similarity). Interacts with NKAPL (PubMed:25875095). Interacts with DHX36; this interaction occurs in a RNA-dependent manner (By similarity). Interacts weakly with CRY1; this interaction is enhanced in the presence of FBXL3 (PubMed:26776516). Interacts with FBXL3 and BMAL1 (PubMed:26776516). Interacts with NCOR1 (PubMed:19037247). Interacts with RARA (By similarity). Interacts with SETD5 (PubMed:30455454). O88895; Q9Z2D6: Mecp2; NbExp=5; IntAct=EBI-302263, EBI-1188816; O88895; Q9Z1E3: Nfkbia; NbExp=2; IntAct=EBI-302263, EBI-644427; O88895; Q64104: Nr2e1; NbExp=2; IntAct=EBI-302263, EBI-15658561; O88895; Q3TKT4: Smarca4; NbExp=2; IntAct=EBI-302263, EBI-1210244; Nucleus Cytoplasm Cytoplasm, cytosol Note=Colocalizes with XBP1 and AKT1 in the cytoplasm. Predominantly expressed in the nucleus in the presence of CCAR2 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=O88895-1; Sequence=Displayed; Name=Short; IsoId=O88895-2; Sequence=VSP_002080; Sumoylated in vitro. Deubiquitinated on 'Lys-63'-linked ubiquitin chains by USP38; leading to a decreased level of histone acetylation. Liver-specific knockout mice exhibit low amplitude of circadian rhythms, dampened E-box-driven transcription and a significant reduction in the protein levels of BMAL1 and CRY1 in the liver. Belongs to the histone deacetylase family. HD type 1 subfamily. Sequence=AAC36305.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=AAC36306.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=AAC67258.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter chromatin positive regulation of protein phosphorylation DNA binding chromatin binding transcription corepressor activity histone deacetylase activity protein binding nucleus nucleoplasm cytoplasm Golgi apparatus cytosol plasma membrane chromatin organization protein deacetylation regulation of mitotic cell cycle transcription factor binding histone deacetylation hydrolase activity transcriptional repressor complex deacetylase activity enzyme binding cyclin binding positive regulation of protein ubiquitination chromatin DNA binding regulation of protein stability positive regulation of TOR signaling NAD-dependent histone deacetylase activity (H3-K14 specific) negative regulation of interleukin-1 production negative regulation of tumor necrosis factor production circadian regulation of gene expression protein deacetylase activity regulation of multicellular organism growth positive regulation of protein import into nucleus regulation of circadian rhythm histone deacetylase binding negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of neuron apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of protein export from nucleus rhythmic process GTPase binding NF-kappaB binding spindle assembly histone H3 deacetylation histone H4 deacetylation cellular response to fluid shear stress mitotic spindle histone H4-K12 deacetylation positive regulation of type B pancreatic cell apoptotic process negative regulation of cardiac muscle cell differentiation uc008erl.1 uc008erl.2 uc008erl.3 uc008erl.4 
ENSMUST00000043503.11 Scube3 ENSMUST00000043503.11 signal peptide, CUB domain, EGF-like 3, transcript variant 1 (from RefSeq NM_001004366.2) B2KF22 ENSMUST00000043503.1 ENSMUST00000043503.10 ENSMUST00000043503.2 ENSMUST00000043503.3 ENSMUST00000043503.4 ENSMUST00000043503.5 ENSMUST00000043503.6 ENSMUST00000043503.7 ENSMUST00000043503.8 ENSMUST00000043503.9 NM_001004366 Q66PY1 Q68FG9 SCUB3_MOUSE Scube3 uc008bqd.1 uc008bqd.2 uc008bqd.3 Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development (PubMed:33308444). It acts as a coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors (By similarity). It is required for ligand-induced recruitment of BMP receptors to lipid rafts (PubMed:33308444). Binds to TGFBR2 and activates TGFB signaling (By similarity). Forms homooligomers. Forms heterooligomers with SCUBE1 and SCUBE2. Interacts with TGFBR2 through the CUB domain; this interaction does not affect TGFB1-binding to TGFBR2. Interacts with BMP2, BMP4 and BMP7; the interaction is mediated by the CUB domain. Interacts with BMPR1A, BMPR1B and BMPR2; the interaction with BMPR1A and BMPR1B is BMP2- and BMP4-dependent. Secreted Cell surface Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q66PY1-1; Sequence=Displayed; Name=2 ; IsoId=Q66PY1-2; Sequence=VSP_052168, VSP_052169; Highly expressed in femur and humerus with little or no expression in non-bone tissues. N-glycosylated. Proteolytic cleavage produces a CUB-containing C-terminal fragment that retains the ability to bind to TGFBR2. This reaction is catalyzed in vitro by MMP2 and, to a lesser extent, by MMP9 (By similarity). Knockout mice are viable and do not show any macroscopically visible abnormality at birth. At day P1, however, knockout mice are shorter than their control littermates, and show misaligned upper/lower incisors and altered craniofacial development. All appendicular (forelimbs and hindlimbs) and axial (skull, vertebral column, and rib cage) skeletal elements are smaller than in control animals. The defective skeletal growth persists up to adulthood. calcium ion binding extracellular region extracellular space plasma membrane cell surface positive regulation of smoothened signaling pathway protein homooligomerization protein heterooligomerization uc008bqd.1 uc008bqd.2 uc008bqd.3 
ENSMUST00000043517.8 Pvr ENSMUST00000043517.8 poliovirus receptor (from RefSeq NM_027514.2) D7Ertd458e ENSMUST00000043517.1 ENSMUST00000043517.2 ENSMUST00000043517.3 ENSMUST00000043517.4 ENSMUST00000043517.5 ENSMUST00000043517.6 ENSMUST00000043517.7 NM_027514 Pvr Q8K094 Q8K094_MOUSE Tage4 uc009fno.1 uc009fno.2 uc009fno.3 uc009fno.4 virus receptor activity positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target protein binding plasma membrane cell-cell adherens junction homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell surface membrane integral component of membrane cell migration signaling receptor activity susceptibility to natural killer cell mediated cytotoxicity protein homodimerization activity dynein light chain binding viral entry into host cell cell adhesion molecule binding susceptibility to T cell mediated cytotoxicity cell-cell adhesion uc009fno.1 uc009fno.2 uc009fno.3 uc009fno.4 
ENSMUST00000043521.5 Sec22a ENSMUST00000043521.5 SEC22 homolog A, vesicle trafficking protein, transcript variant 11 (from RefSeq NR_184801.1) ENSMUST00000043521.1 ENSMUST00000043521.2 ENSMUST00000043521.3 ENSMUST00000043521.4 NR_184801 Q8BH47 Q91Z54 SC22A_MOUSE Sec22a Sec22l2 uc007zbk.1 uc007zbk.2 May be involved in vesicle transport between the ER and the Golgi complex. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the synaptobrevin family. Sequence=AAH10189.2; Type=Erroneous initiation; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane ER to Golgi vesicle-mediated transport protein transport membrane integral component of membrane vesicle-mediated transport uc007zbk.1 uc007zbk.2 
ENSMUST00000043531.10 Ripor1 ENSMUST00000043531.10 RHO family interacting cell polarization regulator 1 (from RefSeq NM_001081241.2) ENSMUST00000043531.1 ENSMUST00000043531.2 ENSMUST00000043531.3 ENSMUST00000043531.4 ENSMUST00000043531.5 ENSMUST00000043531.6 ENSMUST00000043531.7 ENSMUST00000043531.8 ENSMUST00000043531.9 Fam65a G5E8A2 Kiaa1930 NM_001081241 Q68FE6 Q80T73 Q8K0T1 Q9D6R4 RIPR1_MOUSE Ripor1 uc009ndj.1 uc009ndj.2 uc009ndj.3 uc009ndj.4 Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation. Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation. Interacts (via N-terminus) with RHOA (GTP-bound form); this interaction links active RHOA to STK24 and STK26 kinases. Interacts with RHOB. Interacts with RHOC. Interacts (via C-terminus) with PDCD10; this interaction occurs in a Rho-independent manner. Interacts (via C- terminus) with STK24; this interaction occurs in a PDCD10-dependent and Rho-independent manner. Interacts (via C-terminus) with STK26; this interaction occurs in a PDCD10-dependent and Rho-independent manner. Interacts (via N-terminus) with 14-3-3 proteins; these interactions occur in a Rho-dependent manner. Cytoplasm Golgi apparatus Note=Localizes to the podocyte major processes and cell body (PubMed:17251388). Colocalized with STK26 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with STK26 upon serum stimulation in a Rho- and PDCD10-dependent manner (By similarity). Expressed in the kidney exclusively by glomerular podocytes. Belongs to the RIPOR family. Sequence=AAH06820.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH30451.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB26677.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC65855.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cytoplasm Golgi apparatus Rho protein signal transduction cellular response to starvation response to wounding membrane positive regulation of cell migration cell leading edge protein localization to Golgi apparatus negative regulation of Rho protein signal transduction establishment of Golgi localization 14-3-3 protein binding positive regulation of intracellular protein transport cellular response to chemokine negative regulation of Rho guanyl-nucleotide exchange factor activity uc009ndj.1 uc009ndj.2 uc009ndj.3 uc009ndj.4 
ENSMUST00000043550.11 Traf3ip3 ENSMUST00000043550.11 TRAF3 interacting protein 3 (from RefSeq NM_153137.4) ENSMUST00000043550.1 ENSMUST00000043550.10 ENSMUST00000043550.2 ENSMUST00000043550.3 ENSMUST00000043550.4 ENSMUST00000043550.5 ENSMUST00000043550.6 ENSMUST00000043550.7 ENSMUST00000043550.8 ENSMUST00000043550.9 G3X949 G3X949_MOUSE NM_153137 Traf3ip3 uc007eec.1 uc007eec.2 uc007eec.3 uc007eec.4 membrane integral component of membrane uc007eec.1 uc007eec.2 uc007eec.3 uc007eec.4 
ENSMUST00000043551.11 Ankib1 ENSMUST00000043551.11 ankyrin repeat and IBR domain containing 1, transcript variant 4 (from RefSeq NM_001289529.1) AKIB1_MOUSE ENSMUST00000043551.1 ENSMUST00000043551.10 ENSMUST00000043551.2 ENSMUST00000043551.3 ENSMUST00000043551.4 ENSMUST00000043551.5 ENSMUST00000043551.6 ENSMUST00000043551.7 ENSMUST00000043551.8 ENSMUST00000043551.9 Kiaa1386 NM_001289529 Q6AXE1 Q6ZPS6 uc008who.1 uc008who.2 uc008who.3 uc008who.4 uc008who.5 Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence=; Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT- type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain. Belongs to the RBR family. Lacks one Cys residue in the IBR-type zinc finger domain that is one of the conserved features of the family. Sequence=AAH79620.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; ubiquitin ligase complex protein polyubiquitination ubiquitin-protein transferase activity cytoplasm ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity ubiquitin conjugating enzyme binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity uc008who.1 uc008who.2 uc008who.3 uc008who.4 uc008who.5 
ENSMUST00000043577.3 Cldn5 ENSMUST00000043577.3 claudin 5 (from RefSeq NM_013805.4) Bec1 CLD5_MOUSE ENSMUST00000043577.1 ENSMUST00000043577.2 NM_013805 O54942 O88789 uc007yok.1 uc007yok.2 uc007yok.3 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a critical component of endothelial tight junctions that control pericellular permeability. The knockout mice lacking this gene died within 10 h of birth and the blood-brain barrier in these mice against small molecules was selectively affected. This gene is expressed strongly in endothelium of normal lung and plays a regulation role during acrolein-induced acute lung injury. [provided by RefSeq, Aug 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK077282.1, AF035814.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Interacts with MPDZ (By similarity). Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Widely expressed with highest levels in the lung. Belongs to the claudin family. structural molecule activity protein binding plasma membrane cell-cell junction bicellular tight junction cell-cell junction assembly transforming growth factor beta receptor signaling pathway membrane integral component of membrane apicolateral plasma membrane lateral plasma membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction paranode region of axon myelination identical protein binding Schmidt-Lanterman incisure response to ethanol cell-cell adhesion positive regulation of establishment of endothelial barrier cortical actin cytoskeleton uc007yok.1 uc007yok.2 uc007yok.3 
ENSMUST00000043584.5 Tubb4b ENSMUST00000043584.5 tubulin, beta 4B class IVB (from RefSeq NM_146116.2) ENSMUST00000043584.1 ENSMUST00000043584.2 ENSMUST00000043584.3 ENSMUST00000043584.4 NM_146116 P05217 P68372 Q3TKF0 Q3UJ73 Q99JZ6 TBB4B_MOUSE Tubb2c uc008iqs.1 uc008iqs.2 uc008iqs.3 uc008iqs.4 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Cytoplasm, cytoskeleton. Widely expressed. Expressed in the retina and the cochlea. The highly acidic C-terminal region may bind cations such as calcium. The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation. Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility (PubMed:33414192). Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:15890843). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (PubMed:23897886). Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle double-stranded RNA binding GTPase activity structural constituent of cytoskeleton GTP binding cytoplasm cytoskeleton microtubule microtubule-based process myelin sheath tubulin complex uc008iqs.1 uc008iqs.2 uc008iqs.3 uc008iqs.4 
ENSMUST00000043589.8 Kif16b ENSMUST00000043589.8 kinesin family member 16B, transcript variant 7 (from RefSeq NM_001421419.1) B1AVY7 ENSMUST00000043589.1 ENSMUST00000043589.2 ENSMUST00000043589.3 ENSMUST00000043589.4 ENSMUST00000043589.5 ENSMUST00000043589.6 ENSMUST00000043589.7 KI16B_MOUSE Kiaa1590 NM_001421419 O35056 Q3TUD2 Q6ZPM0 Q8BZZ9 uc008mpz.1 uc008mpz.2 uc008mpz.3 Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. Interacts with PTPN21 (By similarity). Interacts with RAB14. Cytoplasm, cytoskeleton Early endosome membrane Cytoplasm Cytoplasm, cytoskeleton, spindle Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14. The PX domain mediates binding to phosphatidylinositol 3- phosphate (PtdIns(3)P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). Does not bind phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (By similarity). Embryonic death. Embryos are arrested at the blastocyst stage: the primitive endoderm and epiblast cannot be distinguished and appear as cell clumps resembling the inner cell mass (ICM) of the blastocyst. Embryos do not develop an epiblast epithelium and the uterine reaction appears to be incomplete. Development of the primitive endoderm and a basement membrane derived from it are severely affected in embryos at 4.5 dpc. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Sequence=BAC98211.1; Type=Miscellaneous discrepancy; Note=Partially unspliced pre-RNA.; Evidence=; nucleotide binding formation of primary germ layer regulation of receptor recycling microtubule motor activity ATP binding phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm endosome early endosome cytosol cytoskeleton kinesin complex microtubule Golgi to endosome transport microtubule-based movement epidermal growth factor receptor signaling pathway endoderm development microtubule binding lipid binding fibroblast growth factor receptor signaling pathway ATP-dependent microtubule motor activity, plus-end-directed membrane ATPase activity Rab GTPase binding early endosome membrane phosphatidylinositol-3-phosphate binding receptor catabolic process phosphatidylinositol binding phosphatidylinositol-3,4-bisphosphate binding early endosome to late endosome transport phagocytic vesicle cellular response to interferon-gamma phosphatidylinositol-3,5-bisphosphate binding uc008mpz.1 uc008mpz.2 uc008mpz.3 
ENSMUST00000043598.14 Tlcd2 ENSMUST00000043598.14 TLC domain containing 2, transcript variant 1 (from RefSeq NM_027249.3) ENSMUST00000043598.1 ENSMUST00000043598.10 ENSMUST00000043598.11 ENSMUST00000043598.12 ENSMUST00000043598.13 ENSMUST00000043598.2 ENSMUST00000043598.3 ENSMUST00000043598.4 ENSMUST00000043598.5 ENSMUST00000043598.6 ENSMUST00000043598.7 ENSMUST00000043598.8 ENSMUST00000043598.9 NM_027249 Q8VC26 Q9D837 TLCD2_MOUSE uc007kdw.1 uc007kdw.2 uc007kdw.3 uc007kdw.4 Regulates the composition and fluidity of the plasma membrane (By similarity). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (By similarity). Does not appear to have any effect on LCPUFA synthesis (By similarity). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VC26-1; Sequence=Displayed; Name=2; IsoId=Q8VC26-2; Sequence=VSP_032879, VSP_032880; Belongs to the TLCD family. molecular_function plasma membrane plasma membrane organization membrane integral component of membrane phospholipid homeostasis membrane assembly regulation of membrane lipid distribution uc007kdw.1 uc007kdw.2 uc007kdw.3 uc007kdw.4 
ENSMUST00000043604.6 Gna11 ENSMUST00000043604.6 guanine nucleotide binding protein, alpha 11 (from RefSeq NM_010301.4) ENSMUST00000043604.1 ENSMUST00000043604.2 ENSMUST00000043604.3 ENSMUST00000043604.4 ENSMUST00000043604.5 Gna11 NM_010301 Q3UPA1 Q3UPA1_MOUSE uc007gil.1 uc007gil.2 uc007gil.3 Cell membrane ; Lipid-anchor Belongs to the G-alpha family. G(q) subfamily. nucleotide binding G-protein coupled receptor binding GTPase activity GTP binding cytoplasm signal transduction G-protein coupled receptor signaling pathway guanyl nucleotide binding G-protein beta/gamma-subunit complex binding uc007gil.1 uc007gil.2 uc007gil.3 
ENSMUST00000043610.13 Ric1 ENSMUST00000043610.13 RAB6A GEF complex partner 1 (from RefSeq NM_001081319.1) C030046E11Rik E9QPA1 E9QPA1_MOUSE ENSMUST00000043610.1 ENSMUST00000043610.10 ENSMUST00000043610.11 ENSMUST00000043610.12 ENSMUST00000043610.2 ENSMUST00000043610.3 ENSMUST00000043610.4 ENSMUST00000043610.5 ENSMUST00000043610.6 ENSMUST00000043610.7 ENSMUST00000043610.8 ENSMUST00000043610.9 NM_001081319 Ric1 uc008hds.1 uc008hds.2 uc008hds.3 cytosol intracellular protein transport membrane Rab guanyl-nucleotide exchange factor activity Rab GTPase binding macromolecular complex RIC1-RGP1 guanyl-nucleotide exchange factor complex retrograde transport, endosome to Golgi positive regulation of GTPase activity negative regulation of cellular protein catabolic process uc008hds.1 uc008hds.2 uc008hds.3 
ENSMUST00000043612.10 Pla2g4c ENSMUST00000043612.10 phospholipase A2, group IVC (cytosolic, calcium-independent), transcript variant 2 (from RefSeq NM_001004762.3) ENSMUST00000043612.1 ENSMUST00000043612.2 ENSMUST00000043612.3 ENSMUST00000043612.4 ENSMUST00000043612.5 ENSMUST00000043612.6 ENSMUST00000043612.7 ENSMUST00000043612.8 ENSMUST00000043612.9 NM_001004762 PA24C_MOUSE Pla2g4c Q08EC7 Q3UWS1 Q64GA5 Q7TN01 uc009fft.1 uc009fft.2 uc009fft.3 uc009fft.4 Calcium-independent phospholipase, lysophospholipase and O- acyltransferase involved in phospholipid remodeling. Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles. Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at the sn-1 position of lysophospholipids. Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency. Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn- glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40812; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence=; Reaction=1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3- phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O- hexadecyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41067, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:55430, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41068; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40571, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73003, ChEBI:CHEBI:76079; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40572; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15178; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=2 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2- dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3- phosphocholine; Xref=Rhea:RHEA:40879, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40880; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl- sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3- phosphoethanolamine + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40899, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998, ChEBI:CHEBI:73004, ChEBI:CHEBI:73005; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40900; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl- sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3- phosphocholine + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63764, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999, ChEBI:CHEBI:73004, ChEBI:CHEBI:143890; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63765; Evidence=; Reaction=2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2- dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3- phosphoethanolamine; Xref=Rhea:RHEA:63768, ChEBI:CHEBI:73004, ChEBI:CHEBI:73005, ChEBI:CHEBI:143890; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63769; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn- glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3- phosphocholine + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:63656, ChEBI:CHEBI:16870, ChEBI:CHEBI:64496, ChEBI:CHEBI:72744, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63657; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)- sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-hexadecanoyl- sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:63772, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998, ChEBI:CHEBI:77288, ChEBI:CHEBI:77303; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63773; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O- hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl- sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63760, ChEBI:CHEBI:64496, ChEBI:CHEBI:72744, ChEBI:CHEBI:73004, ChEBI:CHEBI:143890; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63761; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3- phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63788, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003, ChEBI:CHEBI:75036, ChEBI:CHEBI:78268; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63789; Evidence=; Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3- phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63776, ChEBI:CHEBI:55430, ChEBI:CHEBI:64496, ChEBI:CHEBI:75036, ChEBI:CHEBI:78268; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63777; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2- (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63784, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002, ChEBI:CHEBI:77288, ChEBI:CHEBI:149549; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63785; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63780, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003, ChEBI:CHEBI:77288, ChEBI:CHEBI:77295; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63781; Evidence=; Nucleus, nucleoplasm Nucleus envelope Cytoplasm, cell cortex Cytoplasm, cytoskeleton, spindle Note=In germinal vesicle stage oocytes and early embryos, shows mainly uniform nuclear and cortical expression. During germinal vesicle breakdown, found in intensely stained foci which accumulate near the dissolving nuclear envelope. Also localizes to spindle poles at metaphase II. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q64GA5-1; Sequence=Displayed; Name=2; IsoId=Q64GA5-2; Sequence=VSP_058982; Highly expressed in ovary, where it localizes to oocytes in preantral and antral stage follicles (at protein level). Not detected in other tissues tested. Strongly expressed in oocytes at the germinal vesicle stage, and in zygotes (at protein level). Maternal expression persists in embryos at the 2-cell stage but then declines rapidly and is completely lost by the morula stage (at protein level). phospholipase activity phospholipase A2 activity calcium ion binding calcium-dependent phospholipid binding nucleus nuclear envelope nucleoplasm cytoplasm spindle cytoskeleton cell cortex lipid metabolic process phospholipid catabolic process lipid catabolic process hydrolase activity glycerophospholipid catabolic process calcium-dependent phospholipase A2 activity calcium-independent phospholipase A2 activity uc009fft.1 uc009fft.2 uc009fft.3 uc009fft.4 
ENSMUST00000043616.7 Zyg11b ENSMUST00000043616.7 zyg-ll family member B, cell cycle regulator, transcript variant 2 (from RefSeq NM_001426993.1) B9EID5 ENSMUST00000043616.1 ENSMUST00000043616.2 ENSMUST00000043616.3 ENSMUST00000043616.4 ENSMUST00000043616.5 ENSMUST00000043616.6 Kiaa1730 NM_001426993 Q148T6 Q3TM33 Q3TMB0 Q3TRM3 Q3UFA3 Q3UFS0 Q80TA0 ZY11B_MOUSE Zyg11b uc008uax.1 uc008uax.2 uc008uax.3 uc008uax.4 Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation. Interacts with ELOC/Elongin C. Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin BC. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UFS0-1; Sequence=Displayed; Name=2; IsoId=Q3UFS0-2; Sequence=VSP_028225, VSP_028226; Name=3; IsoId=Q3UFS0-3; Sequence=VSP_028227, VSP_028228; Belongs to the zyg-11 family. Cul2-RING ubiquitin ligase complex uc008uax.1 uc008uax.2 uc008uax.3 uc008uax.4 
ENSMUST00000043624.9 Med13 ENSMUST00000043624.9 mediator complex subunit 13 (from RefSeq NM_001080931.2) ENSMUST00000043624.1 ENSMUST00000043624.2 ENSMUST00000043624.3 ENSMUST00000043624.4 ENSMUST00000043624.5 ENSMUST00000043624.6 ENSMUST00000043624.7 ENSMUST00000043624.8 Kiaa0593 MED13_MOUSE NM_001080931 Q3V3P6 Q5SWW4 Q6ZQ90 Thrap1 Trap240 uc007ksk.1 uc007ksk.2 uc007ksk.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Nucleus Belongs to the Mediator complex subunit 13 family. transcription cofactor activity transcription coactivator activity nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter mediator complex cholesterol homeostasis negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter thyroid hormone receptor binding triglyceride homeostasis uc007ksk.1 uc007ksk.2 uc007ksk.3 
ENSMUST00000043627.8 Mrpl12 ENSMUST00000043627.8 mitochondrial ribosomal protein L12 (from RefSeq NM_027204.3) B1ATZ3 ENSMUST00000043627.1 ENSMUST00000043627.2 ENSMUST00000043627.3 ENSMUST00000043627.4 ENSMUST00000043627.5 ENSMUST00000043627.6 ENSMUST00000043627.7 NM_027204 Q3TKJ3 Q99JS8 Q9DB15 RM12_MOUSE Rpml12 uc007mta.1 uc007mta.2 uc007mta.3 As a component of the mitochondrial large ribosomal subunit, it plays a role in mitochondrial translation. Associates with mitochondrial RNA polymerase to activate transcription. Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity). Interacts with NOA1. Mitochondrion matrix Belongs to the bacterial ribosomal protein bL12 family. structural constituent of ribosome mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit ribosome transcription from mitochondrial promoter translation positive regulation of transcription, DNA-templated uc007mta.1 uc007mta.2 uc007mta.3 
ENSMUST00000043637.14 Mitf ENSMUST00000043637.14 melanogenesis associated transcription factor, transcript variant 4 (from RefSeq NM_001410051.1) A0A0N4SVJ5 Bw ENSMUST00000043637.1 ENSMUST00000043637.10 ENSMUST00000043637.11 ENSMUST00000043637.12 ENSMUST00000043637.13 ENSMUST00000043637.2 ENSMUST00000043637.3 ENSMUST00000043637.4 ENSMUST00000043637.5 ENSMUST00000043637.6 ENSMUST00000043637.7 ENSMUST00000043637.8 ENSMUST00000043637.9 MITF_MOUSE Mi NM_001410051 O08885 O88203 Q08843 Q08874 Q3U2D2 Q60781 Q60782 Q9JIJ0 Q9JIJ1 Q9JIJ2 Q9JIJ3 Q9JIJ4 Q9JIJ5 Q9JIJ6 Q9JKX9 Vit uc009daz.1 uc009daz.2 uc009daz.3 uc009daz.4 Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (By similarity). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation (By similarity). Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity (By similarity). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) (By similarity). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup- derived retinal pigment epithelium (By similarity). Homodimer or heterodimer; dimerization is mediated via the coiled coil region (PubMed:23207919). Efficient DNA binding requires dimerization with another bHLH protein (PubMed:23207919). Binds DNA in the form of homodimer or heterodimer with either TFE3, TFEB or TFEC (PubMed:23207919). Interacts with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD); promoting its recruitment to lysosomal membrane in the presence of nutrients (By similarity). Interacts with KARS1 (PubMed:14975237). Identified in a complex with HINT1 and CTNNB1 (By similarity). Interacts with VSX2 (PubMed:23028343). Nucleus Cytoplasm Lysosome membrane Note=When nutrients are present, recruited to the lysosomal membrane via association with GDP-bound RagC/RRAGC (or RagD/RRAGD): it is then phosphorylated by MTOR. Phosphorylation by MTOR promotes ubiquitination and degradation. Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus. Phosphorylation by MARK3/cTAK1 promotes association with 14-3-3/YWHA adapters and retention in the cytosol. Event=Alternative splicing; Named isoforms=9; Name=A; IsoId=Q08874-1; Sequence=Displayed; Name=A1; IsoId=Q08874-2; Sequence=VSP_002133; Name=A2; IsoId=Q08874-3; Sequence=VSP_002131, VSP_002134, VSP_002136; Name=H; IsoId=Q08874-4; Sequence=VSP_002129; Name=H1; IsoId=Q08874-5; Sequence=VSP_002129, VSP_002132; Name=H2; IsoId=Q08874-6; Sequence=VSP_002129, VSP_002132, VSP_002135; Name=H3; IsoId=Q08874-7; Sequence=VSP_002129, VSP_002133; Name=M; IsoId=Q08874-8; Sequence=VSP_002130; Name=M1; IsoId=Q08874-9; Sequence=VSP_002130, VSP_002134; In the adult, expressed at high levels in the heart, skin, skeletal muscle, intestine, stomach, kidney, ovary, lung, spleen and brain. In the embryo, expressed in developing eye, ear, skin and heart. Isoform M is expressed in melanocytes and also in the embryonic and adult heart while isoform A and isoform H are more widely expressed. The leucine zipper region is part of a larger coiled coil. When nutrients are present, phosphorylation by MTOR at Ser-5 via non-canonical mTORC1 pathway promotes ubiquitination by the SCF(BTRC) complex, followed by degradation (By similarity). Phosphorylation at Ser-405 significantly enhances the ability to bind the tyrosinase promoter (By similarity). Phosphorylation by MARK3/cTAK1 at Ser-280 promotes association with 14-3-3/YWHA adapters and retention in the cytosol (By similarity). Phosphorylated at Ser-180 and Ser-516 following KIT signaling, triggering a short live activation: Phosphorylation at Ser-180 and Ser-516 by MAPK and RPS6KA1, respectively, activate the transcription factor activity but also promote ubiquitination and subsequent degradation by the proteasome (By similarity). Phosphorylated in response to blue light (415nm) (By similarity). Ubiquitinated by the SCF(BTRC) and SCF(FBXW11) complexes following phosphorylation ar Ser-5 by MTOR, leading to its degradation by the proteasome (By similarity). Ubiquitinated following phosphorylation at Ser-180, leading to subsequent degradation by the proteasome (By similarity). Deubiquitinated by USP13, preventing its degradation (By similarity). Note=Defects in Mitf are the cause of microphthalmia (mi), a condition characterized by loss of pigmentation; reduced eye size; failure of secondary bone resorption; reduced numbers of mast cells; early onset of deafness, and which gives rise to a number of different phenotypes. Among them, microphthalmia-eyeless white (mi-ew) has a normal appearance at the heterozygous state, but shows white coat; eyes almost absent and eyelids never open at homozygosity. Microphthalmia- black and white spot (mi-bws) is normal at heterozygosity, and presents white spots and black eyes at homozygous state. Microphthalmia-white (mi-wh) has reduced coat color and eye pigmentation; spots on toes, tail and belly; inner ear defects at heterozygosity, and at homozygosity shows white coat; eyes small and inner iris slightly pigmented; spinal ganglia, adrenal medulla and dermis smaller than normal, and inner ear defects. Microphthalmia-vitiligo (mi-vi) has normal phenotype at heterozygosity, but shows gradual depigmentation of coat, skin and eyes; and retinal degeneration at homozygosity. Microphthalmia-spotted (mi-sp) shows normal phenotype; at homozygosity, however, tyrosinase activity in skin is reduced. Microphthalmia- defective irism (mi-di) has reduced retinal pigmentation at heterozygosity and shows white coat; eyes of reduced sized and possible mild osteoporosis at homozygosity. Microphthalmia-cloudy eyed (mi-ce) has a normal appearance at the heterozygous state, but shows white coat; eyes of reduced size and unpigmented at homozygosity. Microphthalmia-red-eyed white (mi-rw) has a normal appearance at the homozygous state, but shows white coat with one or more pigmented spots around the head/and or tail; eyes are small and red at heterozygosity. Microphthalmia-black-eyed white (mi-bw) shows a white coat but normal sized eyes which reamin black at homozygosity. Belongs to the MiT/TFE family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development regulation of gene expression positive regulation of gene expression Wnt signaling pathway cell differentiation osteoclast differentiation melanocyte differentiation negative regulation of cell migration macromolecular complex regulation of cell proliferation camera-type eye development negative regulation of apoptotic process pigmentation sequence-specific DNA binding canonical Wnt signaling pathway involved in negative regulation of apoptotic process cell fate commitment regulation of osteoclast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter bone remodeling protein dimerization activity macromolecular complex assembly E-box binding positive regulation of DNA-templated transcription, initiation regulation of RNA biosynthetic process uc009daz.1 uc009daz.2 uc009daz.3 uc009daz.4 
ENSMUST00000043650.8 Fam222a ENSMUST00000043650.8 family with sequence similarity 222, member A (from RefSeq NM_001004180.1) ENSMUST00000043650.1 ENSMUST00000043650.2 ENSMUST00000043650.3 ENSMUST00000043650.4 ENSMUST00000043650.5 ENSMUST00000043650.6 ENSMUST00000043650.7 F222A_MOUSE NM_001004180 Q6PGH4 uc008yzt.1 uc008yzt.2 uc008yzt.3 Belongs to the FAM222 family. molecular_function cellular_component biological_process uc008yzt.1 uc008yzt.2 uc008yzt.3 
ENSMUST00000043654.10 Tubg2 ENSMUST00000043654.10 tubulin, gamma 2 (from RefSeq NM_134028.2) ENSMUST00000043654.1 ENSMUST00000043654.2 ENSMUST00000043654.3 ENSMUST00000043654.4 ENSMUST00000043654.5 ENSMUST00000043654.6 ENSMUST00000043654.7 ENSMUST00000043654.8 ENSMUST00000043654.9 NM_134028 Q8VCK3 TBG2_MOUSE uc007lnm.1 uc007lnm.2 uc007lnm.3 uc007lnm.4 Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Mainly localizes to the centrosome, but a fraction is found outside of the centrosome in the cytoplasm. Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome. Belongs to the tubulin family. mitotic sister chromatid segregation nucleotide binding meiotic spindle organization microtubule cytoskeleton organization pericentriolar material mitotic cell cycle gamma-tubulin complex GTPase activity structural constituent of cytoskeleton GTP binding nucleus cytoplasm centrosome microtubule organizing center spindle cytoskeleton microtubule spindle microtubule cytoplasmic microtubule microtubule-based process microtubule nucleation mitotic spindle organization cytoplasmic microtubule organization uc007lnm.1 uc007lnm.2 uc007lnm.3 uc007lnm.4 
ENSMUST00000043674.15 Vars2 ENSMUST00000043674.15 valyl-tRNA synthetase 2, mitochondrial (from RefSeq NM_175137.4) E9QMJ4 ENSMUST00000043674.1 ENSMUST00000043674.10 ENSMUST00000043674.11 ENSMUST00000043674.12 ENSMUST00000043674.13 ENSMUST00000043674.14 ENSMUST00000043674.2 ENSMUST00000043674.3 ENSMUST00000043674.4 ENSMUST00000043674.5 ENSMUST00000043674.6 ENSMUST00000043674.7 ENSMUST00000043674.8 ENSMUST00000043674.9 Kiaa1885 NM_175137 Q3U2A8 Q69Z78 Q6PGG3 Q6ZQL7 Q8BIN9 SYVM_MOUSE Vars2l uc012arq.1 uc012arq.2 uc012arq.3 Catalyzes the attachment of valine to tRNA(Val) in a two-step reaction: valine is first activated by ATP to form Val-AMP and then transferred to the acceptor end of tRNA(Val). Reaction=ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl- tRNA(Val); Xref=Rhea:RHEA:10704, Rhea:RHEA-COMP:9672, Rhea:RHEA- COMP:9708, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57762, ChEBI:CHEBI:78442, ChEBI:CHEBI:78537, ChEBI:CHEBI:456215; EC=6.1.1.9; Evidence=; Mitochondrion Belongs to the class-I aminoacyl-tRNA synthetase family. Sequence=BAC29932.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32566.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAD32566.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence=; nucleotide binding aminoacyl-tRNA editing activity aminoacyl-tRNA ligase activity valine-tRNA ligase activity ATP binding mitochondrion cytosol translation tRNA aminoacylation for protein translation valyl-tRNA aminoacylation ligase activity uc012arq.1 uc012arq.2 uc012arq.3 
ENSMUST00000043675.9 Atp5mg ENSMUST00000043675.9 ATP synthase membrane subunit g (from RefSeq NM_013795.5) ATP5L_MOUSE Atp5l Atp5mg ENSMUST00000043675.1 ENSMUST00000043675.2 ENSMUST00000043675.3 ENSMUST00000043675.4 ENSMUST00000043675.5 ENSMUST00000043675.6 ENSMUST00000043675.7 ENSMUST00000043675.8 NM_013795 O70590 Q5M9M8 Q9CPQ8 uc009per.1 uc009per.2 uc009per.3 uc009per.4 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). Mitochondrion. Mitochondrion inner membrane. Belongs to the ATPase g subunit family. mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) mitochondrion mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex ATP biosynthetic process ion transport hydrogen-exporting ATPase activity, phosphorylative mechanism hydrogen ion transmembrane transporter activity ATP synthesis coupled proton transport membrane proton-transporting ATP synthase complex, coupling factor F(o) ATP metabolic process ATPase activity proton-transporting ATP synthase activity, rotational mechanism uc009per.1 uc009per.2 uc009per.3 uc009per.4 
ENSMUST00000043680.9 Tubg1 ENSMUST00000043680.9 tubulin, gamma 1 (from RefSeq NM_134024.3) ENSMUST00000043680.1 ENSMUST00000043680.2 ENSMUST00000043680.3 ENSMUST00000043680.4 ENSMUST00000043680.5 ENSMUST00000043680.6 ENSMUST00000043680.7 ENSMUST00000043680.8 NM_134024 Q6F4J1 Q6F4J1_MOUSE Tubg1 tubg1 uc007lnk.1 uc007lnk.2 uc007lnk.3 Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Belongs to the tubulin family. nucleotide binding gamma-tubulin complex GTPase activity GTP binding cytoplasm centrosome polar microtubule microtubule microtubule-based process microtubule nucleation cytoplasmic microtubule organization identical protein binding recycling endosome uc007lnk.1 uc007lnk.2 uc007lnk.3 
ENSMUST00000043696.9 Serpinf2 ENSMUST00000043696.9 serine (or cysteine) peptidase inhibitor, clade F, member 2 (from RefSeq NM_008878.2) A2AP_MOUSE ENSMUST00000043696.1 ENSMUST00000043696.2 ENSMUST00000043696.3 ENSMUST00000043696.4 ENSMUST00000043696.5 ENSMUST00000043696.6 ENSMUST00000043696.7 ENSMUST00000043696.8 NM_008878 Pli Q61247 uc007kdr.1 uc007kdr.2 uc007kdr.3 Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase- 3/TMPRSS7 and chymotrypsin (By similarity). Forms protease inhibiting heterodimer with TMPRSS7. Secreted. Expressed by the liver and secreted in plasma. Proteolytically cleaved at Pro-35 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin. Belongs to the serpin family. protease binding regulation of blood vessel diameter by renin-angiotensin serine-type endopeptidase inhibitor activity extracellular region fibrinogen complex extracellular space acute-phase response cell surface negative regulation of peptidase activity negative regulation of plasminogen activation negative regulation of endopeptidase activity collagen fibril organization peptidase inhibitor activity positive regulation of collagen biosynthetic process protein homodimerization activity positive regulation of cell differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade blood vessel morphogenesis positive regulation of smooth muscle cell proliferation positive regulation of stress fiber assembly negative regulation of fibrinolysis positive regulation of ERK1 and ERK2 cascade positive regulation of transforming growth factor beta production uc007kdr.1 uc007kdr.2 uc007kdr.3 
ENSMUST00000043707.7 Rhbdd2 ENSMUST00000043707.7 rhomboid domain containing 2, transcript variant 1 (from RefSeq NM_146002.2) ENSMUST00000043707.1 ENSMUST00000043707.2 ENSMUST00000043707.3 ENSMUST00000043707.4 ENSMUST00000043707.5 ENSMUST00000043707.6 NM_146002 Q3TT71 Q4G0C4 Q8VEK2 RHBD2_MOUSE Rhbdl7 uc008zyr.1 uc008zyr.2 uc008zyr.3 Might form homotrimers; these trimers are only formed in retina. Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VEK2-1; Sequence=Displayed; Name=2; IsoId=Q8VEK2-2; Sequence=VSP_021249; Widely expressed, including in retina and brain (at protein level), as well as in kidney, testis and ovary. Expressed in all layers of the retina, including inner segments of photoreceptor cells and ganglion cells (at protein level). In the developing eye, already detected at 10.5 dpc. Expression increases from 12.5 though 18.5 dpc in all retinal cells (at protein level). At P1, expressed in a small number of cells at the level of the ganglion cell layer and in the inner edge of the ventricular zone of the retina. The number of expressing cells increases and, by P8 to P11, entirely occupies the ganglion cell layer and inner nuclear layer. At that stage, not detected in the photoreceptor cell bodies of the outer nuclear layer. At P21, expressed in all nuclear layers of the retina, including cones (at protein level). Belongs to the peptidase S54 family. Although strongly related to the peptidase S54 family, it lacks the conserved active sites, suggesting that it has no peptidase activity. Golgi membrane endopeptidase activity serine-type endopeptidase activity nucleus nucleoplasm Golgi apparatus proteolysis membrane integral component of membrane perinuclear region of cytoplasm uc008zyr.1 uc008zyr.2 uc008zyr.3 
ENSMUST00000043709.8 Gna15 ENSMUST00000043709.8 guanine nucleotide binding protein, alpha 15 (from RefSeq NM_010304.3) ENSMUST00000043709.1 ENSMUST00000043709.2 ENSMUST00000043709.3 ENSMUST00000043709.4 ENSMUST00000043709.5 ENSMUST00000043709.6 ENSMUST00000043709.7 GNA15_MOUSE Gna-15 NM_010304 P30678 Q8K1S0 uc007gij.1 uc007gij.2 uc007gij.3 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Expressed primarily in hematopoietic cells. Coexpressed with EDG6 at the same relative levels in all tissues examined, with the highest levels in adult spleen and lung. Belongs to the G-alpha family. G(q) subfamily. nucleotide binding G-protein coupled receptor binding GTPase activity GTP binding heterotrimeric G-protein complex signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway membrane guanyl nucleotide binding G-protein beta/gamma-subunit complex binding metal ion binding positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway phospholipase C-activating dopamine receptor signaling pathway uc007gij.1 uc007gij.2 uc007gij.3 
ENSMUST00000043711.9 Gm10135 ENSMUST00000043711.9 Gm10135 (from geneSymbol) ENSMUST00000043711.1 ENSMUST00000043711.2 ENSMUST00000043711.3 ENSMUST00000043711.4 ENSMUST00000043711.5 ENSMUST00000043711.6 ENSMUST00000043711.7 ENSMUST00000043711.8 F6TEE5 F6TEE5_MOUSE Gm10135 uc290whc.1 uc290whc.2 molecular_function cellular_component biological_process uc290whc.1 uc290whc.2 
ENSMUST00000043716.9 Cinp ENSMUST00000043716.9 cyclin dependent kinase 2 interacting protein, transcript variant 1 (from RefSeq NM_026048.4) CINP_MOUSE ENSMUST00000043716.1 ENSMUST00000043716.2 ENSMUST00000043716.3 ENSMUST00000043716.4 ENSMUST00000043716.5 ENSMUST00000043716.6 ENSMUST00000043716.7 ENSMUST00000043716.8 NM_026048 Q8C063 Q9D0V8 Q9D8P9 uc007pcb.1 uc007pcb.2 uc007pcb.3 Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling in response to DNA damage. Also involved in the cytoplasmic maturation steps of pre- 60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. Promotes maturation of pre-60S ribosome together with AFG2A, AFG2B and AIRIM. Homodimer. Interacts with CDK2 and CDC7. Interacts with the components of the replication complex, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 and with ORC2-containing complexes. Interacts with ATRIP. Interacts with CEP152. Associates with pre-60S ribosomal particles. Interacts with AIRIM. Nucleus Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D0V8-1; Sequence=Displayed; Name=2; IsoId=Q9D0V8-2; Sequence=VSP_032525, VSP_032526; Name=3; IsoId=Q9D0V8-3; Sequence=VSP_032527, VSP_032528; Phosphorylated by CDC7 but not by CDK2. Belongs to the CINP family. molecular_function cellular_component nucleus DNA replication DNA repair cellular response to DNA damage stimulus cell cycle biological_process cell division uc007pcb.1 uc007pcb.2 uc007pcb.3 
ENSMUST00000043718.12 Mab21l4 ENSMUST00000043718.12 mab-21-like 4, transcript variant 1 (from RefSeq NM_172411.4) ENSMUST00000043718.1 ENSMUST00000043718.10 ENSMUST00000043718.11 ENSMUST00000043718.2 ENSMUST00000043718.3 ENSMUST00000043718.4 ENSMUST00000043718.5 ENSMUST00000043718.6 ENSMUST00000043718.7 ENSMUST00000043718.8 ENSMUST00000043718.9 MB214_MOUSE NM_172411 Q5FWA3 Q8C4S6 Q8CEZ4 uc007cdk.1 uc007cdk.2 uc007cdk.3 uc007cdk.4 molecular_function cellular_component biological_process uc007cdk.1 uc007cdk.2 uc007cdk.3 uc007cdk.4 
ENSMUST00000043722.10 Lgals3bp ENSMUST00000043722.10 lectin, galactoside-binding, soluble, 3 binding protein (from RefSeq NM_011150.3) Cycap ENSMUST00000043722.1 ENSMUST00000043722.2 ENSMUST00000043722.3 ENSMUST00000043722.4 ENSMUST00000043722.5 ENSMUST00000043722.6 ENSMUST00000043722.7 ENSMUST00000043722.8 ENSMUST00000043722.9 LG3BP_MOUSE Mama NM_011150 O35649 Q07797 Q3U631 Q3U8K4 Q3UDL5 uc007moz.1 uc007moz.2 uc007moz.3 Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity). Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID (By similarity). Interacts with PPIC (in vitro). The unglycosylated form interacts with PDE4DIP isoform 2/MMG8/SMYLE; this interaction may connect a pericentrosomal complex to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (By similarity). Secreted Secreted, extracellular space, extracellular matrix Detected in embryo, liver, spleen, kidney, lung, heart, intestine, thymus and lymph node. Up-regulated by TNF and IFNG. N-glycosylated. scavenger receptor activity protein binding extracellular region extracellular space endocytosis cell adhesion membrane uc007moz.1 uc007moz.2 uc007moz.3 
ENSMUST00000043725.9 Cntnap5a ENSMUST00000043725.9 contactin associated protein-like 5A, transcript variant 1 (from RefSeq NM_001371013.1) CTP5A_MOUSE Caspr5-1 ENSMUST00000043725.1 ENSMUST00000043725.2 ENSMUST00000043725.3 ENSMUST00000043725.4 ENSMUST00000043725.5 ENSMUST00000043725.6 ENSMUST00000043725.7 ENSMUST00000043725.8 NM_001371013 Q0V8T9 uc007cia.1 uc007cia.2 uc007cia.3 May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication. Membrane ; Single-pass type I membrane protein Expressed in brain. Expressed from 6 dpc in brain. Belongs to the neurexin family. aspartic-type endopeptidase activity proteolysis cell adhesion membrane integral component of membrane uc007cia.1 uc007cia.2 uc007cia.3 
ENSMUST00000043726.8 Angptl6 ENSMUST00000043726.8 angiopoietin-like 6 (from RefSeq NM_145154.2) ANGL6_MOUSE Agf ENSMUST00000043726.1 ENSMUST00000043726.2 ENSMUST00000043726.3 ENSMUST00000043726.4 ENSMUST00000043726.5 ENSMUST00000043726.6 ENSMUST00000043726.7 NM_145154 Q8R0Z6 uc009ojj.1 uc009ojj.2 uc009ojj.3 May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure. Secreted Highly expressed in the liver, specifically in hepatocytes, and weakly in the heart. Expressed in hematopoietic cells, platelets and mast cells, and detected at wounded skin. angiogenesis extracellular region multicellular organism development secretory granule cell differentiation uc009ojj.1 uc009ojj.2 uc009ojj.3 
ENSMUST00000043754.8 Ctsll3 ENSMUST00000043754.8 cathepsin L-like 3 (from RefSeq NM_027344.3) 2310051M13Rik Ctsll3 ENSMUST00000043754.1 ENSMUST00000043754.2 ENSMUST00000043754.3 ENSMUST00000043754.4 ENSMUST00000043754.5 ENSMUST00000043754.6 ENSMUST00000043754.7 NM_027344 Q3ULP7 Q3ULP7_MOUSE uc007qvr.1 uc007qvr.2 uc007qvr.3 Lysosome Belongs to the peptidase C1 family. cysteine-type endopeptidase activity extracellular space lysosome proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity proteolysis involved in cellular protein catabolic process uc007qvr.1 uc007qvr.2 uc007qvr.3 
ENSMUST00000043757.15 Abcf1 ENSMUST00000043757.15 ATP-binding cassette, sub-family F member 1 (from RefSeq NM_013854.1) ABCF1_MOUSE ENSMUST00000043757.1 ENSMUST00000043757.10 ENSMUST00000043757.11 ENSMUST00000043757.12 ENSMUST00000043757.13 ENSMUST00000043757.14 ENSMUST00000043757.2 ENSMUST00000043757.3 ENSMUST00000043757.4 ENSMUST00000043757.5 ENSMUST00000043757.6 ENSMUST00000043757.7 ENSMUST00000043757.8 ENSMUST00000043757.9 NM_013854 Q6NV71 Q6P542 uc008cjk.1 uc008cjk.2 uc008cjk.3 Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity). Interacts (via N-terminus) with EIF2S1; the interaction is independent of its phosphorylated status. Associates (via both ABC transporter domains) with the ribosomes (By similarity). Cytoplasm Nucleus, nucleoplasm Nucleus envelope Phosphorylated at phosphoserine and phosphothreonine. Phosphorylation on Ser-107 and Ser-138 by CK2; inhibits association of EIF2 with ribosomes (By similarity). Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. nucleotide binding ATP binding nucleus nuclear envelope nucleoplasm cytoplasm cytosol ribosome translational initiation translation activator activity ATPase activity polysomal ribosome ribosome binding positive regulation of translation ribosome biogenesis uc008cjk.1 uc008cjk.2 uc008cjk.3 
ENSMUST00000043760.15 Mvk ENSMUST00000043760.15 mevalonate kinase, transcript variant 2 (from RefSeq NM_023556.3) ENSMUST00000043760.1 ENSMUST00000043760.10 ENSMUST00000043760.11 ENSMUST00000043760.12 ENSMUST00000043760.13 ENSMUST00000043760.14 ENSMUST00000043760.2 ENSMUST00000043760.3 ENSMUST00000043760.4 ENSMUST00000043760.5 ENSMUST00000043760.6 ENSMUST00000043760.7 ENSMUST00000043760.8 ENSMUST00000043760.9 KIME_MOUSE Mvk NM_023556 Q9R008 uc008yzr.1 uc008yzr.2 uc008yzr.3 uc008yzr.4 uc008yzr.5 This gene encodes mevalonate kinase, a key enzyme involved in the biosynthesis of cholesterol and non-sterol isoprenes. The complete lack of encoded protein is lethal to mouse embryos. Mice lacking one allele of this gene exhibit increased levels of mevalonate in spleen, heart and kidney, as well as increased levels of serum immunoglobulins A and D. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Reaction=(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+); Xref=Rhea:RHEA:17065, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36464, ChEBI:CHEBI:58146, ChEBI:CHEBI:456216; EC=2.7.1.36; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Farnesyl pyrophosphate and geranyl pyrophosphate inhibit mevalonate kinase activity by binding competitively at the ATP- binding sites. Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3. Homodimer. Cytoplasm Peroxisome Belongs to the GHMP kinase family. Mevalonate kinase subfamily. nucleotide binding magnesium ion binding mRNA binding mevalonate kinase activity ATP binding cytoplasm peroxisome cytosol lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process steroid metabolic process cholesterol metabolic process isoprenoid biosynthetic process sterol biosynthetic process kinase activity phosphorylation transferase activity negative regulation of translation isopentenyl diphosphate biosynthetic process, mevalonate pathway identical protein binding metal ion binding negative regulation of inflammatory response sequence-specific mRNA binding uc008yzr.1 uc008yzr.2 uc008yzr.3 uc008yzr.4 uc008yzr.5 
ENSMUST00000043767.9 Upf3a ENSMUST00000043767.9 UPF3 regulator of nonsense transcripts homolog A (yeast) (from RefSeq NM_025924.2) ENSMUST00000043767.1 ENSMUST00000043767.2 ENSMUST00000043767.3 ENSMUST00000043767.4 ENSMUST00000043767.5 ENSMUST00000043767.6 ENSMUST00000043767.7 ENSMUST00000043767.8 NM_025924 Q3ULJ3 Q3ULJ3_MOUSE Upf3a uc009kyn.1 uc009kyn.2 uc009kyn.3 uc009kyn.4 Belongs to the RENT3 family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nucleic acid binding mRNA binding nucleus nucleolus cytoplasm cytosol response to unfolded protein exon-exon junction complex telomeric DNA binding intracellular membrane-bounded organelle positive regulation of translation uc009kyn.1 uc009kyn.2 uc009kyn.3 uc009kyn.4 
ENSMUST00000043774.11 Stpg3 ENSMUST00000043774.11 sperm tail PG rich repeat containing 3, transcript variant 1 (from RefSeq NM_028961.2) A2RSX4 ENSMUST00000043774.1 ENSMUST00000043774.10 ENSMUST00000043774.2 ENSMUST00000043774.3 ENSMUST00000043774.4 ENSMUST00000043774.5 ENSMUST00000043774.6 ENSMUST00000043774.7 ENSMUST00000043774.8 ENSMUST00000043774.9 NM_028961 STPG3_MOUSE Stpg3 uc008iqp.1 uc008iqp.2 uc008iqp.3 molecular_function cellular_component biological_process uc008iqp.1 uc008iqp.2 uc008iqp.3 
ENSMUST00000043775.9 Kdm3b ENSMUST00000043775.9 KDM3B lysine (K)-specific demethylase 3B (from RefSeq NM_001081256.1) B9EKS2 ENSMUST00000043775.1 ENSMUST00000043775.2 ENSMUST00000043775.3 ENSMUST00000043775.4 ENSMUST00000043775.5 ENSMUST00000043775.6 ENSMUST00000043775.7 ENSMUST00000043775.8 Jhdm2b Jmjd1b KDM3B_MOUSE Kiaa1082 NM_001081256 Q2VPQ5 Q5U5V7 Q6P9K3 Q6ZPY7 Q8CCE2 Q8K2A5 Q9CU57 uc008elq.1 uc008elq.2 uc008elq.3 Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate May have tumor suppressor activity (By similarity). Reaction=2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60188, Rhea:RHEA-COMP:15541, Rhea:RHEA- COMP:15546, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61976; EC=1.14.11.65; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZPY7-1; Sequence=Displayed; Name=2; IsoId=Q6ZPY7-3; Sequence=VSP_061228, VSP_061229, VSP_061230; Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors. Belongs to the JHDM2 histone demethylase family. Sequence=AAH38376.1; Type=Frameshift; Evidence=; Sequence=BAC98091.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; chromatin transcription regulatory region sequence-specific DNA binding nucleus nucleoplasm chromatin organization antioxidant activity oxidoreductase activity chromatin DNA binding histone demethylase activity (H3-K9 specific) histone H3-K9 demethylation metal ion binding dioxygenase activity oxidation-reduction process response to cisplatin cellular oxidant detoxification uc008elq.1 uc008elq.2 uc008elq.3 
ENSMUST00000043785.8 Stap2 ENSMUST00000043785.8 signal transducing adaptor family member 2, transcript variant 1 (from RefSeq NM_145934.3) ENSMUST00000043785.1 ENSMUST00000043785.2 ENSMUST00000043785.3 ENSMUST00000043785.4 ENSMUST00000043785.5 ENSMUST00000043785.6 ENSMUST00000043785.7 NM_145934 Q8BWS2 Q8R0L1 STAP2_MOUSE uc008dao.1 uc008dao.2 uc008dao.3 uc008dao.4 uc008dao.5 Substrate of protein kinase PTK6 (By similarity). May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. Interacts with PTK6 and CSF1R. Cytoplasm Membrane ; Peripheral membrane protein Note=The translocation to the membranes occurs in response to EGF when the protein is overexpressed in fibroblastic cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R0L1-1; Sequence=Displayed; Name=2; IsoId=Q8R0L1-2; Sequence=VSP_013401, VSP_013402; Widely expressed. Phosphorylated on tyrosine. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation. protein binding cytoplasm plasma membrane positive regulation of signal transduction membrane signaling adaptor activity uc008dao.1 uc008dao.2 uc008dao.3 uc008dao.4 uc008dao.5 
ENSMUST00000043797.6 Capza3 ENSMUST00000043797.6 capping actin protein of muscle Z-line subunit alpha 3 (from RefSeq NM_007605.5) CAZA3_MOUSE Cappa3 ENSMUST00000043797.1 ENSMUST00000043797.2 ENSMUST00000043797.3 ENSMUST00000043797.4 ENSMUST00000043797.5 Gsg3 NM_007605 P70190 Q9D4N3 uc009eoa.1 uc009eoa.2 uc009eoa.3 uc009eoa.4 uc009eoa.5 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid. Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5 (By similarity). Exclusively expressed in the testis. Expressed in 24-day-old and adult testis, but not in 4-, 10- and 16-day-old testis. Belongs to the F-actin-capping protein alpha subunit family. acrosomal vesicle actin binding cytoplasm spermatid development F-actin capping protein complex membrane actin cytoskeleton organization actin cortical patch cortical cytoskeleton actin filament binding barbed-end actin filament capping actin filament capping uc009eoa.1 uc009eoa.2 uc009eoa.3 uc009eoa.4 uc009eoa.5 
ENSMUST00000043805.15 Foxred1 ENSMUST00000043805.15 FAD-dependent oxidoreductase domain containing 1, transcript variant 1 (from RefSeq NM_172291.3) ENSMUST00000043805.1 ENSMUST00000043805.10 ENSMUST00000043805.11 ENSMUST00000043805.12 ENSMUST00000043805.13 ENSMUST00000043805.14 ENSMUST00000043805.2 ENSMUST00000043805.3 ENSMUST00000043805.4 ENSMUST00000043805.5 ENSMUST00000043805.6 ENSMUST00000043805.7 ENSMUST00000043805.8 ENSMUST00000043805.9 FXRD1_MOUSE NM_172291 Q3TQB2 Q8R1D0 uc009ost.1 uc009ost.2 uc009ost.3 uc009ost.4 uc009ost.5 Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly. Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Associates with components of the mitochondrial respiratory chain complex I. Mitochondrion inner membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TQB2-1; Sequence=Displayed; Name=2; IsoId=Q3TQB2-2; Sequence=VSP_022630; cytoplasm mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I membrane integral component of membrane oxidoreductase activity mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc009ost.1 uc009ost.2 uc009ost.3 uc009ost.4 uc009ost.5 
ENSMUST00000043812.15 Pkn2 ENSMUST00000043812.15 protein kinase N2 (from RefSeq NM_178654.4) ENSMUST00000043812.1 ENSMUST00000043812.10 ENSMUST00000043812.11 ENSMUST00000043812.12 ENSMUST00000043812.13 ENSMUST00000043812.14 ENSMUST00000043812.2 ENSMUST00000043812.3 ENSMUST00000043812.4 ENSMUST00000043812.5 ENSMUST00000043812.6 ENSMUST00000043812.7 ENSMUST00000043812.8 ENSMUST00000043812.9 NM_178654 PKN2_MOUSE Prk2 Prkcl2 Q3TBR3 Q80WS2 Q8BJL7 Q8BL62 Q8BWW9 uc008rpe.1 uc008rpe.2 uc008rpe.3 PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Kinase activity is activated upon binding to GTP- bound Rho1/Rac1 GTPases. Activated by caspase-3 (CASP3) cleavage during apoptosis. Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids. Two specific sites, Thr-815 (activation loop of the kinase domain) and Thr-957 (turn motif), need to be phosphorylated for its full activation (By similarity). Interacts (via the REM repeats) with RHOA (GTP-bound form preferentially) and interacts (via the REM repeats) with RAC1 (GTP- bound form preferentially); the interactions induce its autophosphorylation (PubMed:17403031, PubMed:20974804). Interacts with NCK1 (via SH3 domains) (PubMed:8910519). Interacts with RHOC. Interacts with NCK1 and NCK2 (By similarity). Interacts with CD44 (PubMed:17403031). Interacts (via C-terminal kinase domain) with PDPK1; the interaction stimulates PDPK1 kinase activity (By similarity). Interacts with MAP3K2; the interaction activates PRK2 kinase activity in a MAP3K2-independent kinase activity (PubMed:10818102). Interacts (via C-terminal domain) with AKT1; the interaction occurs with the C- terminal cleavage product of PRK2 in apoptotic cells. Interacts (via C- terminus) with PTPN13 (via PDZ 3 domain). Interacts with CDK10 (By similarity). Cytoplasm Nucleus Membrane Cell projection, lamellipodium Cytoplasm, cytoskeleton Cleavage furrow Midbody Cell junction Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BWW9-1; Sequence=Displayed; Name=2; IsoId=Q8BWW9-2; Sequence=VSP_012042; Name=3; IsoId=Q8BWW9-3; Sequence=VSP_042185, VSP_042186; Ubiquitous. Highly expressed in liver and lung Expressed in astrocytes (at protein level). Ubiquitous. The N-terminal regioninterferes with the interaction between AKT1 and the C-terminal regionof PKN2. The C1 domain does not bind the diacylglycerol (DAG). The apoptotic C-terminal cleavage product inhibits EGF-induced kinase activity of AKT1 phosphorylation at 'Thr-308' and 'Ser-473' sites, PDPK1 autophosphorylation and kinases PRKCD and PRKCZ phosphorylations. Phosphorylated during mitosis (By similarity). Autophosphorylated. Phosphorylated. Phosphorylated by CDK10 (By similarity). Activated by limited proteolysis with trypsin. Proteolytically cleaved by caspase-3 during the induction of apoptotic cell death. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding nucleus nucleoplasm cytoplasm centrosome cytosol cytoskeleton plasma membrane protein phosphorylation apoptotic process cell cycle cell adhesion signal transduction epithelial cell migration membrane kinase activity phosphorylation nuclear body transferase activity GTP-Rho binding peptidyl-serine phosphorylation lamellipodium cell projection organization cell junction midbody cleavage furrow positive regulation of cytokinesis macromolecular complex intracellular signal transduction histone deacetylase binding cell projection apical junction complex apical junction assembly positive regulation of viral genome replication intermediate filament cytoskeleton positive regulation of mitotic cell cycle perinuclear region of cytoplasm cell division RNA polymerase binding regulation of cell motility uc008rpe.1 uc008rpe.2 uc008rpe.3 
ENSMUST00000043813.3 Nudt15 ENSMUST00000043813.3 nudix hydrolase 15, transcript variant 2 (from RefSeq NM_172527.3) ENSMUST00000043813.1 ENSMUST00000043813.2 Mth2 NM_172527 NUD15_MOUSE Nudt15 Q8BG93 uc007upv.1 uc007upv.2 uc007upv.3 May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:12767940). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (By similarity). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:12767940). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (By similarity). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673). Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- phosphate + diphosphate + H(+); Xref=Rhea:RHEA:23996, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.9; Evidence=; Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'- deoxyribonucleoside 5'-phosphate + diphosphate + H(+); Xref=Rhea:RHEA:44644, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:65317; EC=3.6.1.9; Evidence=; Reaction=a 5'-end CoA-ribonucleoside in mRNA + H2O = (R)-4'- phosphopantetheine + a 5'-end phospho-adenosine-phospho- ribonucleoside in mRNA + 2 H(+); Xref=Rhea:RHEA:67592, Rhea:RHEA- COMP:15719, Rhea:RHEA-COMP:17276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:61723, ChEBI:CHEBI:144051, ChEBI:CHEBI:172371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67593; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Magnesium may be the real cofactor in vivo. ; Kinetic parameters: KM=32 uM for 8-oxo-dGTP ; KM=75 uM for dGTP ; Homodimer. Interacts with PCNA; interaction is disrupted in response to UV irradiation. Progressive reduction of protein levels after 4 month of age in the hippocampus of SAMP8 mouse, a mouse with early aging syndrome and reduced ability of learning and memory. Has the ability to complement a mutation of mutT in E.coli and thereby completely suppress the increased frequency of spontaneous mutations. Belongs to the Nudix hydrolase family. mitotic cell cycle response to reactive oxygen species nucleotide diphosphatase activity cytosol purine nucleotide catabolic process dGTP catabolic process 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity purine deoxyribonucleoside triphosphate catabolic process hydrolase activity nucleoside-diphosphatase activity NADH pyrophosphatase activity 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity DNA protection exogenous drug catabolic process metal ion binding nucleoside-triphosphate diphosphatase activity regulation of proteasomal protein catabolic process nucleoside phosphate catabolic process uc007upv.1 uc007upv.2 uc007upv.3 
ENSMUST00000043814.5 Fig4 ENSMUST00000043814.5 FIG4 phosphoinositide 5-phosphatase (from RefSeq NM_133999.1) ENSMUST00000043814.1 ENSMUST00000043814.2 ENSMUST00000043814.3 ENSMUST00000043814.4 FIG4_MOUSE Kiaa0274 NM_133999 Q6A092 Q91WF7 Sac3 uc007exk.1 uc007exk.2 uc007exk.3 The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate. Has serine- protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production. In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3-phosphate) + phosphate; Xref=Rhea:RHEA:32955, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57923, ChEBI:CHEBI:58088; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32956; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol 4-phosphate) + phosphate; Xref=Rhea:RHEA:22764, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456; EC=3.1.3.36; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22765; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + phosphate; Xref=Rhea:RHEA:25528, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57658, ChEBI:CHEBI:57836; EC=3.1.3.86; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25529; Evidence=; Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20630; Evidence=; Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14 (By similarity) (PubMed:19037259). VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities (By similarity). Endosome membrane Note=Localization requires VAC14 and PIKFYVE. Wide-spread. Note=Defects in Fig4 are the cause of the pale tremor phenotype which is a multi-organ disorder with neuronal degeneration in the central nervous system, peripheral neuronopathy and diluted pigmentation. At postnatal day three (P3), affected homozygotes have diluted pigmentation and reduced size. Intentional tremor develops during the second week after birth, and abnormal limb postures are evident by the third week. There is impaired motor coordination, muscle weakness and 'swimming' gait. There is progressive loss of mobility, reduction in body weight and juvenile lethality. phosphatidylinositol-3-phosphatase activity endosome endoplasmic reticulum Golgi apparatus lipid particle vacuole organization locomotory behavior endosome membrane positive regulation of neuron projection development membrane dephosphorylation hydrolase activity negative regulation of myelination myelin assembly phosphatidylinositol bisphosphate phosphatase activity phosphoric ester hydrolase activity intracellular membrane-bounded organelle pigmentation phosphatidylinositol-4-phosphate phosphatase activity phosphatidylinositol metabolic process neuron development recycling endosome uc007exk.1 uc007exk.2 uc007exk.3 
ENSMUST00000043815.16 Nup205 ENSMUST00000043815.16 nucleoporin 205 (from RefSeq NM_027513.1) B9EJ54 B9EJ54_MOUSE ENSMUST00000043815.1 ENSMUST00000043815.10 ENSMUST00000043815.11 ENSMUST00000043815.12 ENSMUST00000043815.13 ENSMUST00000043815.14 ENSMUST00000043815.15 ENSMUST00000043815.2 ENSMUST00000043815.3 ENSMUST00000043815.4 ENSMUST00000043815.5 ENSMUST00000043815.6 ENSMUST00000043815.7 ENSMUST00000043815.8 ENSMUST00000043815.9 NM_027513 Nup205 uc009bik.1 uc009bik.2 uc009bik.3 uc009bik.4 uc009bik.5 Belongs to the NUP186/NUP192/NUP205 family. nuclear pore nucleocytoplasmic transport structural constituent of nuclear pore nuclear membrane nuclear periphery nuclear pore complex assembly uc009bik.1 uc009bik.2 uc009bik.3 uc009bik.4 uc009bik.5 
ENSMUST00000043822.8 Cblc ENSMUST00000043822.8 Casitas B-lineage lymphoma c, transcript variant 1 (from RefSeq NM_023224.5) CBLC_MOUSE Cbl3 ENSMUST00000043822.1 ENSMUST00000043822.2 ENSMUST00000043822.3 ENSMUST00000043822.4 ENSMUST00000043822.5 ENSMUST00000043822.6 ENSMUST00000043822.7 NM_023224 Q80XL1 Q99PB6 Q9D6L2 Q9D7A9 uc009fnh.1 uc009fnh.2 uc009fnh.3 Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-424', has the highest ubiquitin ligase activity among CBL family proteins. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Phosphorylation at Tyr-340 is necessary and sufficient for the activation of E3 activity. Interacts with Ubiquitin-conjugating enzyme E2 UBE2D2 and UBE2D3. Isoform 1 interacts with EGFR (tyrosine phosphorylated). Interacts with the SH3 domain proteins LYN and CRK. Interacts (via RING-type zinc finger) with TGFB1I1 (via LIM zinc-binding domain 2); the interaction is direct and enhances the E3 activity. Interacts directly with RET (inactive) and CD2AP; dissociates from RET upon RET activation by GDNF which also increases the interaction with CD2AP suggesting dissociation as CBLC:CD2AP complex. Interacts with SRC; the interaction is enhanced when SRC is phosphorylated at 'Tyr-419'. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80XL1-1; Sequence=Displayed; Name=2; IsoId=Q80XL1-2; Sequence=VSP_014946, VSP_014947; Widely expressed in tissues, where the expression is restricted to epithelial cells (at protein level). Expressed at 14.5 dpc in liver, lung and brain. EF-hand-like and Sh2-like domains are required for N-terminal inhibition of E3 activity. The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. Phosphorylated on tyrosines by EGFR. Phosphorylated on multiple tyrosine residues by SRC. Isoform 1, but not isoform 2, is phosphorylated on tyrosines by EGFR. Autoubiquitinated, when phosphorylated at Tyr-340. No visible phenotype. This protein has one functional calcium-binding site. ubiquitin ligase complex phosphotyrosine binding ubiquitin-protein transferase activity epidermal growth factor receptor binding calcium ion binding plasma membrane ubiquitin-dependent protein catabolic process signal transduction cell surface receptor signaling pathway negative regulation of epidermal growth factor-activated receptor activity protein ubiquitination transferase activity SH3 domain binding regulation of signaling receptor tyrosine kinase binding negative regulation of epidermal growth factor receptor signaling pathway negative regulation of MAP kinase activity membrane raft metal ion binding ubiquitin protein ligase activity uc009fnh.1 uc009fnh.2 uc009fnh.3 
ENSMUST00000043839.5 F11r ENSMUST00000043839.5 F11 receptor (from RefSeq NM_172647.2) ENSMUST00000043839.1 ENSMUST00000043839.2 ENSMUST00000043839.3 ENSMUST00000043839.4 JAM1_MOUSE Jam1 Jcam Jcam1 NM_172647 O88792 Q8VC39 uc007doo.1 uc007doo.2 uc007doo.3 Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11447115). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (PubMed:11447115). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (PubMed:9660867). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (By similarity). Involved in platelet activation (By similarity). Interacts with the ninth PDZ domain of MPDZ (By similarity). Interacts with the first PDZ domain of PARD3 (PubMed:11447115). The association between PARD3 and PARD6B probably disrupts this interaction (PubMed:11447115). Interacts with ITGAL (via I-domain) (By similarity). Cell junction, tight junction Cell membrane ; Single-pass type I membrane protein Note=Localized at tight junctions of both epithelial and endothelial cells. The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2. Belongs to the immunoglobulin superfamily. regulation of cytokine production integrin binding plasma membrane cell-cell junction bicellular tight junction cell adhesion leukocyte cell-cell adhesion regulation of cell shape response to radiation membrane integral component of membrane cell junction cell differentiation PDZ domain binding epithelial cell differentiation actomyosin structure organization cytoplasmic vesicle regulation of actin cytoskeleton organization macromolecular complex negative regulation of GTPase activity positive regulation of Rho protein signal transduction memory T cell extravasation slit diaphragm protein homodimerization activity positive regulation of GTPase activity positive regulation of blood pressure intestinal absorption occluding junction cellular response to mechanical stimulus protein localization to plasma membrane establishment of endothelial intestinal barrier regulation of membrane permeability cell-cell adhesion positive regulation of platelet aggregation positive regulation of establishment of endothelial barrier regulation of actin cytoskeleton reorganization uc007doo.1 uc007doo.2 uc007doo.3 
ENSMUST00000043843.12 Lasp1 ENSMUST00000043843.12 LIM and SH3 protein 1 (from RefSeq NM_010688.5) ENSMUST00000043843.1 ENSMUST00000043843.10 ENSMUST00000043843.11 ENSMUST00000043843.2 ENSMUST00000043843.3 ENSMUST00000043843.4 ENSMUST00000043843.5 ENSMUST00000043843.6 ENSMUST00000043843.7 ENSMUST00000043843.8 ENSMUST00000043843.9 LASP1_MOUSE Mln50 NM_010688 Q61792 Q62416 uc007lew.1 uc007lew.2 uc007lew.3 Plays an important role in the regulation of dynamic actin- based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). Interacts with F-actin. Interacts with KBTBD10 (By similarity). Interacts with ANKRD54. Cytoplasm, cell cortex Cytoplasm, cytoskeleton Note=Associated with the F-actin rich cortical cytoskeleton. actin binding protein binding cytoplasm cytoskeleton focal adhesion cell cortex ion transport ion transmembrane transporter activity cortical actin cytoskeleton ion transmembrane transport metal ion binding actin filament binding uc007lew.1 uc007lew.2 uc007lew.3 
ENSMUST00000043848.11 Ncapd2 ENSMUST00000043848.11 non-SMC condensin I complex, subunit D2, transcript variant 1 (from RefSeq NM_146171.2) A0A0R4J0H7 A0A0R4J0H7_MOUSE ENSMUST00000043848.1 ENSMUST00000043848.10 ENSMUST00000043848.2 ENSMUST00000043848.3 ENSMUST00000043848.4 ENSMUST00000043848.5 ENSMUST00000043848.6 ENSMUST00000043848.7 ENSMUST00000043848.8 ENSMUST00000043848.9 NM_146171 Ncapd2 uc009dtt.1 uc009dtt.2 uc009dtt.3 Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Chromosome Nucleus Belongs to the CND1 (condensin subunit 1) family. nuclear chromosome mitotic cell cycle condensed chromosome condensin complex nucleus nucleoplasm cytoplasm cytosol cell cycle mitotic chromosome condensation chromosome condensation histone binding cell division uc009dtt.1 uc009dtt.2 uc009dtt.3 
ENSMUST00000043864.9 Cdc123 ENSMUST00000043864.9 cell division cycle 123, transcript variant 1 (from RefSeq NM_133837.5) CD123_MOUSE ENSMUST00000043864.1 ENSMUST00000043864.2 ENSMUST00000043864.3 ENSMUST00000043864.4 ENSMUST00000043864.5 ENSMUST00000043864.6 ENSMUST00000043864.7 ENSMUST00000043864.8 NM_133837 Q3TTR0 Q8CII2 Q8VE51 uc008ift.1 uc008ift.2 uc008ift.3 ATP-dependent protein-folding chaperone for the eIF2 complex (By similarity). Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits (By similarity). Interacts with the eIF2 complex gamma subunit EIF2S3 (via C- terminus); the interaction is direct. Interacts with the eIF2 complex alpha subunit EIF2S1. Interacts with the eIF2 complex beta subunit EIF2S2. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CII2-1; Sequence=Displayed; Name=2; IsoId=Q8CII2-2; Sequence=VSP_017691, VSP_017692; Phosphorylated. Belongs to the CDC123 family. molecular_function cytoplasm cell cycle cell division uc008ift.1 uc008ift.2 uc008ift.3 
ENSMUST00000043867.11 Rpl22l1 ENSMUST00000043867.11 ribosomal protein L22 like 1, transcript variant 1 (from RefSeq NM_026517.4) ENSMUST00000043867.1 ENSMUST00000043867.10 ENSMUST00000043867.2 ENSMUST00000043867.3 ENSMUST00000043867.4 ENSMUST00000043867.5 ENSMUST00000043867.6 ENSMUST00000043867.7 ENSMUST00000043867.8 ENSMUST00000043867.9 NM_026517 Q9CXU8 Q9D7S7 RL22L_MOUSE uc008ouf.1 uc008ouf.2 uc008ouf.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D7S7-1; Sequence=Displayed; Name=2; IsoId=Q9D7S7-2; Sequence=VSP_019380; Belongs to the eukaryotic ribosomal protein eL22 family. cytoplasmic translation RNA binding structural constituent of ribosome ribosome translation uc008ouf.1 uc008ouf.2 uc008ouf.3 
ENSMUST00000043870.9 Polr2l ENSMUST00000043870.9 polymerase (RNA) II (DNA directed) polypeptide L (from RefSeq NM_025593.1) ENSMUST00000043870.1 ENSMUST00000043870.2 ENSMUST00000043870.3 ENSMUST00000043870.4 ENSMUST00000043870.5 ENSMUST00000043870.6 ENSMUST00000043870.7 ENSMUST00000043870.8 NM_025593 P52436 P62876 Q3UF14 RPAB5_MOUSE uc009klm.1 uc009klm.2 uc009klm.3 uc009klm.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RPABC5 is part of the core element with the central large cleft. Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively (By similarity). The transcriptionally active Pol III complex consists of a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4- POLR3E/RPC5 heterodimer involved in both transcription initiation and termination (By similarity). Nucleus Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family. DNA binding DNA-directed 5'-3' RNA polymerase activity nucleus DNA-directed RNA polymerase II, core complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase I complex transcription, DNA-templated transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter zinc ion binding tRNA transcription from RNA polymerase III promoter metal ion binding RNA polymerase I activity RNA polymerase II activity RNA polymerase III activity uc009klm.1 uc009klm.2 uc009klm.3 uc009klm.4 
ENSMUST00000043873.10 Scgb3a1 ENSMUST00000043873.10 secretoglobin, family 3A, member 1, transcript variant 1 (from RefSeq NM_054037.2) ENSMUST00000043873.1 ENSMUST00000043873.2 ENSMUST00000043873.3 ENSMUST00000043873.4 ENSMUST00000043873.5 ENSMUST00000043873.6 ENSMUST00000043873.7 ENSMUST00000043873.8 ENSMUST00000043873.9 Hin1 NM_054037 Pnsp2 Q920D7 SG3A1_MOUSE Ugrp2 uc007iqw.1 uc007iqw.2 uc007iqw.3 uc007iqw.4 This gene encodes a small secreted protein that may function in the inhibition of cell growth. Expression of the related gene in humans is downregulated via DNA methylation in breast cancers and other tumor types. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. Secreted cytokine-like protein. Inhibits cell growth in vitro. Homodimer; disulfide-linked. Secreted Highly expressed in lung, where it localizes to epithelial cells lining the trachea and bronchi (PubMed:12406855, PubMed:12175512). Expression in lung is mainly restricted to bronchi, submucosal glands of the trachea, and tracheal epithelium, with little expression in terminal bronchioles (PubMed:12406855). Expressed in uterus where it localizes to epithelial cells of the uterine glands (PubMed:12175512). Also detected in heart, stomach and small intestine (PubMed:12175512). Detected in lung at embryonic stage 18.5 dpc. During gestation, expressed in the mammary gland from 6.5 dpc with highest expression at 10.5 dpc. Expression then declines, but later increases again during mammary gland involution at 4-21 days post partum. Belongs to the secretoglobin family. UGRP subfamily. molecular_function cytokine activity extracellular region extracellular space signal transduction positive regulation of myoblast fusion uc007iqw.1 uc007iqw.2 uc007iqw.3 uc007iqw.4 
ENSMUST00000043884.6 Lrrn3 ENSMUST00000043884.6 leucine rich repeat protein 3, neuronal, transcript variant 2 (from RefSeq NM_010733.3) ENSMUST00000043884.1 ENSMUST00000043884.2 ENSMUST00000043884.3 ENSMUST00000043884.4 ENSMUST00000043884.5 LRRN3_MOUSE NM_010733 P97860 Q8CBC6 uc007nln.1 uc007nln.2 uc007nln.3 uc007nln.4 Membrane ; Single-pass type I membrane protein Expressed in the brain, in Stronger expression in the ventricular zone and anlage of thalamus, spinal cord, and dorsal root ganglion in 11-17 dpc cerebellum and cerebral cortex in adults. positive regulation of protein phosphorylation extracellular space plasma membrane membrane integral component of membrane clathrin adaptor complex extracellular matrix macromolecular complex binding positive regulation of synapse assembly uc007nln.1 uc007nln.2 uc007nln.3 uc007nln.4 
ENSMUST00000043897.16 Rhot2 ENSMUST00000043897.16 ras homolog family member T2, transcript variant 1 (from RefSeq NM_145999.3) Arht2 ENSMUST00000043897.1 ENSMUST00000043897.10 ENSMUST00000043897.11 ENSMUST00000043897.12 ENSMUST00000043897.13 ENSMUST00000043897.14 ENSMUST00000043897.15 ENSMUST00000043897.2 ENSMUST00000043897.3 ENSMUST00000043897.4 ENSMUST00000043897.5 ENSMUST00000043897.6 ENSMUST00000043897.7 ENSMUST00000043897.8 ENSMUST00000043897.9 MIRO2_MOUSE NM_145999 Q8JZN7 uc008bch.1 uc008bch.2 uc008bch.3 Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules (By similarity). Interacts with ARMCX3 (PubMed:22569362). Found in a complex with KIF5B, OGT, RHOT1 and TRAK1 (By similarity). Mitochondrion outer membrane ; Single-pass type IV membrane protein Note=Colocalizes with MGARP and RHOT2 at the mitochondria. Ubiquitously expressed. Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation. Belongs to the mitochondrial Rho GTPase family. nucleotide binding GTPase activity calcium ion binding GTP binding mitochondrion mitochondrial outer membrane mitochondrial inner membrane cytosol mitochondrion organization Rho protein signal transduction regulation of mitochondrion organization membrane integral component of membrane hydrolase activity cellular homeostasis integral component of mitochondrial outer membrane metal ion binding mitochondrion transport along microtubule mitochondrial outer membrane permeabilization uc008bch.1 uc008bch.2 uc008bch.3 
ENSMUST00000043898.8 Psenen ENSMUST00000043898.8 presenilin enhancer gamma secretase subunit, transcript variant 1 (from RefSeq NM_025498.3) ENSMUST00000043898.1 ENSMUST00000043898.2 ENSMUST00000043898.3 ENSMUST00000043898.4 ENSMUST00000043898.5 ENSMUST00000043898.6 ENSMUST00000043898.7 NM_025498 PEN2_MOUSE Pen2 Q9CQR7 uc009gez.1 uc009gez.2 uc009gez.3 uc009gez.4 Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:12522139, PubMed:24941111). The gamma- secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:24941111). The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. Belongs to the PEN-2 family. 3D-structure analysis of the human homolog indicates that the membrane topology differs from the predictions. Contrary to predictions, the N-terminus contains two short helices that dip into the membrane, but do not cross it. The C-terminus contains the single transmembrane helix. This gives rise to a topology where the N-terminus is cytoplasmic and the C-terminus is lumenal. protein binding mitochondrion endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane integral component of plasma membrane membrane protein ectodomain proteolysis Notch signaling pathway Notch receptor processing membrane integral component of membrane protein processing Golgi cisterna membrane beta-amyloid formation amyloid precursor protein metabolic process positive regulation of catalytic activity gamma-secretase complex integral component of presynaptic membrane uc009gez.1 uc009gez.2 uc009gez.3 uc009gez.4 
ENSMUST00000043907.14 Mrps34 ENSMUST00000043907.14 mitochondrial ribosomal protein S34 (from RefSeq NM_023260.2) ENSMUST00000043907.1 ENSMUST00000043907.10 ENSMUST00000043907.11 ENSMUST00000043907.12 ENSMUST00000043907.13 ENSMUST00000043907.2 ENSMUST00000043907.3 ENSMUST00000043907.4 ENSMUST00000043907.5 ENSMUST00000043907.6 ENSMUST00000043907.7 ENSMUST00000043907.8 ENSMUST00000043907.9 NM_023260 Q9D2B0 Q9D957 Q9JIK9 RT34_MOUSE Tce2 uc008ayy.1 uc008ayy.2 uc008ayy.3 Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation. Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Widely expressed (at protein liver). Belongs to the mitochondrion-specific ribosomal protein mS34 family. structural constituent of ribosome mitochondrion mitochondrial small ribosomal subunit ribosome mitochondrial translation uc008ayy.1 uc008ayy.2 uc008ayy.3 
ENSMUST00000043911.8 Shfl ENSMUST00000043911.8 shiftless antiviral inhibitor of ribosomal frameshifting (from RefSeq NM_175687.2) ENSMUST00000043911.1 ENSMUST00000043911.2 ENSMUST00000043911.3 ENSMUST00000043911.4 ENSMUST00000043911.5 ENSMUST00000043911.6 ENSMUST00000043911.7 NM_175687 Q05BY8 Q8CAK3 Ryden SHFL_MOUSE Shfl uc012gow.1 uc012gow.2 Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site. May exhibit antiviral activity. Interacts with PABPC1. Found in a complex with PABPC1 and LARP1. Interacts with ELAV1, MOV10 and UPF1; the interactions increase in presence of RNA. Binds to ribosomes. Interacts with GSPT1. Cytoplasm Nucleus Cytoplasm, P-body Note=Predominantly found in t for dsDNA. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CAK3-1; Sequence=Displayed; Name=2; IsoId=Q8CAK3-2; Sequence=VSP_031275; Belongs to the SHFL family. P-body RNA binding nucleus nucleoplasm cytoplasm cytosol regulation of translational termination viral replication complex response to type I interferon response to interferon-gamma response to type III interferon response to interferon-beta ribosome binding negative regulation of viral genome replication defense response to virus viral translational frameshifting sequence-specific mRNA binding negative regulation of translational frameshifting uc012gow.1 uc012gow.2 
ENSMUST00000043914.8 Ints9 ENSMUST00000043914.8 integrator complex subunit 9, transcript variant 1 (from RefSeq NM_153414.5) D14Ertd231e ENSMUST00000043914.1 ENSMUST00000043914.2 ENSMUST00000043914.3 ENSMUST00000043914.4 ENSMUST00000043914.5 ENSMUST00000043914.6 ENSMUST00000043914.7 INT9_MOUSE NM_153414 Q8BP62 Q8CAE4 Q8K114 uc007uiw.1 uc007uiw.2 uc007uiw.3 uc007uiw.4 Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (By similarity). Interacts with ESRRB, ESRRB is probably not a core component of the multiprotein complex Integrator and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (PubMed:26206133). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K114-1; Sequence=Displayed; Name=2; IsoId=Q8K114-2; Sequence=VSP_021470, VSP_021471; Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. INTS9 subfamily. Sequence=BAC36917.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function nucleus nucleoplasm cytosol snRNA processing integrator complex uc007uiw.1 uc007uiw.2 uc007uiw.3 uc007uiw.4 
ENSMUST00000043915.4 Serpina12 ENSMUST00000043915.4 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 (from RefSeq NM_026535.2) ENSMUST00000043915.1 ENSMUST00000043915.2 ENSMUST00000043915.3 NM_026535 Q7TMF5 Q9CQ32 SPA12_MOUSE uc007owp.1 uc007owp.2 Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. Inhibition of KLK7 is enhanced by heparin. Forms a stable complex with KLK7. Secreted Expressed in visceral adipose tissues. The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin- protease complex is highly stable. Glycosylation slightly decreases affinity for heparin, but otherwise has no significant effect on KLK7 inhibitory activity or thermal stability of the protein. Belongs to the serpin family. serine-type endopeptidase inhibitor activity protein binding extracellular region extracellular space plasma membrane negative regulation of peptidase activity negative regulation of endopeptidase activity positive regulation of phosphatidylinositol 3-kinase signaling peptidase inhibitor activity negative regulation of gluconeogenesis positive regulation of insulin receptor signaling pathway negative regulation of lipid biosynthetic process regulation of cholesterol metabolic process regulation of triglyceride metabolic process uc007owp.1 uc007owp.2 
ENSMUST00000043922.7 Zfp653 ENSMUST00000043922.7 zinc finger protein 653, transcript variant 2 (from RefSeq NM_177318.4) ENSMUST00000043922.1 ENSMUST00000043922.2 ENSMUST00000043922.3 ENSMUST00000043922.4 ENSMUST00000043922.5 ENSMUST00000043922.6 NM_177318 Q6YND2 Q8BHT8 Q8CI02 ZN653_MOUSE Zip67 Znf653 uc009onp.1 uc009onp.2 uc009onp.3 uc009onp.4 Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity (By similarity). Interacts with NR5A1. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6YND2-1; Sequence=Displayed; Name=2; IsoId=Q6YND2-2; Sequence=VSP_021015; Highly expressed in testis and spleen. Moderately expressed in lung, adrenal gland, uterus, and ovary. Very low expression in pancreas, heart, skeletal muscle, adipose tissue, kidney, and liver. Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding transcription corepressor activity extracellular region nucleus transcription factor binding metal ion binding receptor antagonist activity AF-2 domain binding extracellular negative regulation of signal transduction negative regulation of nucleic acid-templated transcription negative regulation of receptor activity uc009onp.1 uc009onp.2 uc009onp.3 uc009onp.4 
ENSMUST00000043929.11 Ccdc68 ENSMUST00000043929.11 coiled-coil domain containing 68 (from RefSeq NM_201362.2) CCD68_MOUSE ENSMUST00000043929.1 ENSMUST00000043929.10 ENSMUST00000043929.2 ENSMUST00000043929.3 ENSMUST00000043929.4 ENSMUST00000043929.5 ENSMUST00000043929.6 ENSMUST00000043929.7 ENSMUST00000043929.8 ENSMUST00000043929.9 NM_201362 Q80VD6 Q8BVC4 uc008fnw.1 uc008fnw.2 uc008fnw.3 Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Interacts with CEP170. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localizes to the subdistal appendages of centrioles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BVC4-1; Sequence=Displayed; Name=2; IsoId=Q8BVC4-2; Sequence=VSP_021897; molecular_function cytoplasm centriole cytoskeleton protein localization microtubule anchoring at centrosome intracellular signal transduction uc008fnw.1 uc008fnw.2 uc008fnw.3 
ENSMUST00000043937.9 Ostc ENSMUST00000043937.9 oligosaccharyltransferase complex subunit (non-catalytic) (from RefSeq NM_025509.3) ENSMUST00000043937.1 ENSMUST00000043937.2 ENSMUST00000043937.3 ENSMUST00000043937.4 ENSMUST00000043937.5 ENSMUST00000043937.6 ENSMUST00000043937.7 ENSMUST00000043937.8 NM_025509 OSTC_MOUSE Ostc Q78XF5 Q9CPZ2 uc008rjc.1 uc008rjc.2 uc008rjc.3 uc008rjc.4 Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N- glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. Protein modification; protein glycosylation. Specific component of the STT3A-containing form of the oligosaccharyltransferase (OST) complex (By similarity). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (By similarity). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Interacts with PSEN1 and NCSTN; indicative for an association with the gamma-secretase complex (By similarity). Endoplasmic reticulum Membrane ; Multi-pass membrane protein Belongs to the OSTC family. Sequence=BAB28595.2; Type=Erroneous initiation; Evidence=; molecular_function endoplasmic reticulum protein glycosylation biological_process oligosaccharyltransferase complex membrane integral component of membrane uc008rjc.1 uc008rjc.2 uc008rjc.3 uc008rjc.4 
ENSMUST00000043938.8 Plcl2 ENSMUST00000043938.8 phospholipase C-like 2 (from RefSeq NM_013880.3) ENSMUST00000043938.1 ENSMUST00000043938.2 ENSMUST00000043938.3 ENSMUST00000043938.4 ENSMUST00000043938.5 ENSMUST00000043938.6 ENSMUST00000043938.7 Kiaa1092 NM_013880 PLCL2_MOUSE Plce2 Q3U4E2 Q80TK5 Q8K394 Q9QYG1 uc012avf.1 uc012avf.2 uc012avf.3 May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. Cytoplasm Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells. Ubiquitously expressed, with a strong expression in skeletal muscle. In the PI-PLC X-box Thr-487 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity. B cell proliferation involved in immune response B-1a B cell differentiation phosphatidylinositol phospholipase C activity cytoplasm lipid metabolic process signal transduction gamma-aminobutyric acid signaling pathway phosphoric diester hydrolase activity regulation of synaptic transmission, GABAergic inositol trisphosphate biosynthetic process regulation of peptidyl-serine phosphorylation intracellular signal transduction phosphatidylinositol-mediated signaling GABA receptor binding negative regulation of B cell receptor signaling pathway release of sequestered calcium ion into cytosol inositol 1,4,5 trisphosphate binding positive regulation of receptor binding uc012avf.1 uc012avf.2 uc012avf.3 
ENSMUST00000043944.6 Ano5 ENSMUST00000043944.6 anoctamin 5, transcript variant 1 (from RefSeq NM_177694.7) ANO5_MOUSE ENSMUST00000043944.1 ENSMUST00000043944.2 ENSMUST00000043944.3 ENSMUST00000043944.4 ENSMUST00000043944.5 Gdd1 NM_177694 Q2VPA8 Q3V657 Q75UR0 Q8CC04 Tmem16e uc009hcc.1 uc009hcc.2 uc009hcc.3 uc009hcc.4 This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. Elevated levels of this protein were found in dystrophic mice. In humans, mutations of this gene are associated with with musculoskeletal disorders such as myopathies, muscular dystrophy and gnathodiaphyseal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. Does not exhibit calcium-activated chloride channel (CaCC) activity. Endoplasmic reticulum membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Colocalized with CALR/calreticulin. Shows an intracellular localization. Event=Alternative splicing; Named isoforms=3; Comment=At least 14 isoforms are produced using different combinations of exons 4, 6, 16, 20 and 21.; Name=1; IsoId=Q75UR0-1; Sequence=Displayed; Name=2; IsoId=Q75UR0-2; Sequence=VSP_015628, VSP_015629, VSP_015630, VSP_015631; Name=3; IsoId=Q75UR0-3; Sequence=VSP_035571, VSP_035572; Highly expressed in skeletal muscle, bone tissues and thyroid gland. In the developing embryo, expressed mainly in differentiating and developing somites and is associated with myotomal somite lineages. Up-regulated during the course of myogenic differentiation. Down-regulated during osteoblastic differentiation. The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. Belongs to the anoctamin family. intracellular calcium activated chloride channel activity endoplasmic reticulum endoplasmic reticulum membrane plasma membrane chloride transport membrane integral component of membrane vesicle ion transmembrane transport protein dimerization activity uc009hcc.1 uc009hcc.2 uc009hcc.3 uc009hcc.4 
ENSMUST00000043951.10 Actr1b ENSMUST00000043951.10 ARP1 actin-related protein 1B, centractin beta, transcript variant 2 (from RefSeq NM_146107.3) ACTY_MOUSE ENSMUST00000043951.1 ENSMUST00000043951.2 ENSMUST00000043951.3 ENSMUST00000043951.4 ENSMUST00000043951.5 ENSMUST00000043951.6 ENSMUST00000043951.7 ENSMUST00000043951.8 ENSMUST00000043951.9 NM_146107 Q8R5C5 uc007aqx.1 uc007aqx.2 uc007aqx.3 Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity). Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Belongs to the actin family. ARP1 subfamily. establishment of mitotic spindle orientation nucleotide binding ATP binding cytoplasm centrosome microtubule organizing center cytoskeleton dynactin complex microtubule cytoskeleton nuclear migration along microtubule cell cortex region uc007aqx.1 uc007aqx.2 uc007aqx.3 
ENSMUST00000043961.12 Abca5 ENSMUST00000043961.12 ATP-binding cassette, sub-family A member 5 (from RefSeq NM_147219.2) ABCA5_MOUSE Abca5 ENSMUST00000043961.1 ENSMUST00000043961.10 ENSMUST00000043961.11 ENSMUST00000043961.2 ENSMUST00000043961.3 ENSMUST00000043961.4 ENSMUST00000043961.5 ENSMUST00000043961.6 ENSMUST00000043961.7 ENSMUST00000043961.8 ENSMUST00000043961.9 Kiaa1888 NM_147219 Q3TE17 Q3UUB4 Q6P1Y0 Q6ZPG4 Q810C7 Q8BM46 Q8BXG7 Q8K448 uc007mdm.1 uc007mdm.2 uc007mdm.3 Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465, PubMed:32687853, PubMed:20382126). May play a role in the processing of autolysosomes (PubMed:15870284). Reaction=ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate; Xref=Rhea:RHEA:39051, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39052; Evidence=; Golgi apparatus membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Cell membrane Note=Localized at cell membrane under high cholesterol levels. Expressed in cardiomyocytes, oligodendrocytes and astrocytes in brain, alveolar type 2 cells in lung and follicular cells in the thyroid gland (at protein level). Detected in brain, testis, lung, heart, liver, kidney, skeletal muscle and placenta. Strongly expressed in the basal cells of the seminiferous tubules, interstitial cells consisting of Leydig cells, as well as the tunica albuginea (PubMed:24831815). In the epididymis, specificly and very strongly expressed in the connective tissue outlining the cylindrical epithelium in the corpus and cauda regions, including fibrocytes and smooth muscle cells, as well as within the basal and tall columnar cells of the corpus cylindrical epithelium (PubMed:24831815). Highly expressed in the brain with high expression in cortical and hippocampal neurons and moderately in the lung (PubMed:25125465). Expressed during embryogenesis. Down-regulated by digoxin (PubMed:16445568). Up-regulated by an excess cellular cholesterol level (PubMed:32687853). Up-regulated when ABCA1 is down-regulated (PubMed:32687853). N-glycosylated. Mice display hypothyroidism and lethal heart abnormalities that may be due to altered autolysosomes processing. Belongs to the ABC transporter superfamily. ABCA family. Sequence=BAC28896.2; Type=Erroneous initiation; Evidence=; Golgi membrane nucleotide binding lipid transporter activity ATP binding lysosome lysosomal membrane endosome late endosome Golgi apparatus lipid transport negative regulation of macrophage derived foam cell differentiation membrane integral component of membrane ATPase activity cholesterol transport late endosome membrane cholesterol efflux high-density lipoprotein particle remodeling ATPase activity, coupled to transmembrane movement of substances intracellular membrane-bounded organelle reverse cholesterol transport transmembrane transport uc007mdm.1 uc007mdm.2 uc007mdm.3 
ENSMUST00000043962.9 Cdc16 ENSMUST00000043962.9 CDC16 cell division cycle 16, transcript variant 1 (from RefSeq NM_027276.3) Anapc6 CDC16_MOUSE ENSMUST00000043962.1 ENSMUST00000043962.2 ENSMUST00000043962.3 ENSMUST00000043962.4 ENSMUST00000043962.5 ENSMUST00000043962.6 ENSMUST00000043962.7 ENSMUST00000043962.8 NM_027276 Q8R349 Q9CYX9 uc009kyi.1 uc009kyi.2 uc009kyi.3 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Protein modification; protein ubiquitination. V-shaped homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. Interacts with PPP5C and CDC20. Interacts with CDC26. Interacts with FBXO43. TPR repeats 1-7 mediate homodimerization, while the C-terminal TPR repeats bind to CDC26, burying its hydrophobic N-terminus. Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis (By similarity). Belongs to the APC6/CDC16 family. Sequence=BAB28717.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; protein binding nucleus anaphase-promoting complex cytoplasm centrosome spindle microtubule cell cycle protein ubiquitination cell division protein K11-linked ubiquitination uc009kyi.1 uc009kyi.2 uc009kyi.3 
ENSMUST00000043964.13 Wfs1 ENSMUST00000043964.13 wolframin ER transmembrane glycoprotein (from RefSeq NM_011716.2) ENSMUST00000043964.1 ENSMUST00000043964.10 ENSMUST00000043964.11 ENSMUST00000043964.12 ENSMUST00000043964.2 ENSMUST00000043964.3 ENSMUST00000043964.4 ENSMUST00000043964.5 ENSMUST00000043964.6 ENSMUST00000043964.7 ENSMUST00000043964.8 ENSMUST00000043964.9 NM_011716 Q3TDI2 Q3TDI2_MOUSE Wfs1 uc008xff.1 uc008xff.2 uc008xff.3 negative regulation of transcription from RNA polymerase II promoter kidney development renal water homeostasis calmodulin binding endoplasmic reticulum visual perception sensory perception of sound membrane integral component of membrane integral component of endoplasmic reticulum membrane integral component of synaptic vesicle membrane ER-associated ubiquitin-dependent protein catabolic process pancreas development positive regulation of protein ubiquitination ubiquitin protein ligase binding endoplasmic reticulum calcium ion homeostasis activating transcription factor binding response to endoplasmic reticulum stress olfactory behavior glucose homeostasis negative regulation of programmed cell death negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of neuron apoptotic process calcium-dependent protein binding protein stabilization neurological system process ATPase binding positive regulation of protein metabolic process positive regulation of calcium ion transport calcium ion homeostasis proteasome binding negative regulation of ATF6-mediated unfolded protein response negative regulation of type B pancreatic cell apoptotic process uc008xff.1 uc008xff.2 uc008xff.3 
ENSMUST00000043966.8 Mrpl47 ENSMUST00000043966.8 mitochondrial ribosomal protein L47 (from RefSeq NM_029017.2) ENSMUST00000043966.1 ENSMUST00000043966.2 ENSMUST00000043966.3 ENSMUST00000043966.4 ENSMUST00000043966.5 ENSMUST00000043966.6 ENSMUST00000043966.7 NM_029017 Q5I0U2 Q8CHZ6 Q8K2Y7 RM47_MOUSE uc008owp.1 uc008owp.2 uc008owp.3 uc008owp.4 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene is immediately adjacent to the gene for BRG1/brm-associated factor 53A (also known as BAF complex 53 kDa subunit protein A in humans) in a tail-to-tail orientation. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: BC087953.1, BQ884589.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uL29 family. Sequence=AAH38065.1; Type=Erroneous initiation; Evidence=; structural constituent of ribosome mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit ribosome translation mitochondrial translation uc008owp.1 uc008owp.2 uc008owp.3 uc008owp.4 
ENSMUST00000043970.2 Nutm1 ENSMUST00000043970.2 NUT midline carcinoma, family member 1 (from RefSeq NM_172521.2) ENSMUST00000043970.1 NM_172521 NUTM1_MOUSE Nut Nutm1 Q8BHP2 uc008loq.1 uc008loq.2 Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. Cytoplasm Nucleus Note=Shuttles between nucleus and cytoplasm. Methylated at Gln-1042 by N6AMT1. Phosphorylation on Ser-1022, Ser-1025 or Ser-1027 is important for cytoplasmic export. Belongs to the NUT family. molecular_function cellular_component nucleus cytoplasm biological_process uc008loq.1 uc008loq.2 
ENSMUST00000043975.11 Lin37 ENSMUST00000043975.11 lin-37 DREAM MuvB core complex component, transcript variant 1 (from RefSeq NM_029377.2) ENSMUST00000043975.1 ENSMUST00000043975.10 ENSMUST00000043975.2 ENSMUST00000043975.3 ENSMUST00000043975.4 ENSMUST00000043975.5 ENSMUST00000043975.6 ENSMUST00000043975.7 ENSMUST00000043975.8 ENSMUST00000043975.9 LIN37_MOUSE NM_029377 Q9D8N6 uc009gex.1 uc009gex.2 Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (By similarity). negative regulation of transcription from RNA polymerase II promoter molecular_function transcriptional repressor complex Myb complex uc009gex.1 uc009gex.2 
ENSMUST00000043983.11 Igsf3 ENSMUST00000043983.11 immunoglobulin superfamily, member 3, transcript variant 1 (from RefSeq NM_207205.3) A0A4X9 ENSMUST00000043983.1 ENSMUST00000043983.10 ENSMUST00000043983.2 ENSMUST00000043983.3 ENSMUST00000043983.4 ENSMUST00000043983.5 ENSMUST00000043983.6 ENSMUST00000043983.7 ENSMUST00000043983.8 ENSMUST00000043983.9 IGSF3_MOUSE Kiaa0466 NM_207205 Q6ZQA6 Q7TPV3 uc008qrg.1 uc008qrg.2 uc008qrg.3 uc008qrg.4 Membrane ; Single-pass type I membrane protein Expressed in the lacrimal duct and lacrimal gland. Expressed in the lacrimal duct at embryonic day (E)19 and in both the lacrimal duct and lacrimal gland at post natal day (P)30. Sequence=BAC97961.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function membrane integral component of membrane lacrimal gland development uc008qrg.1 uc008qrg.2 uc008qrg.3 uc008qrg.4 
ENSMUST00000043990.14 Edc3 ENSMUST00000043990.14 enhancer of mRNA decapping 3, transcript variant 1 (from RefSeq NM_153799.4) EDC3_MOUSE ENSMUST00000043990.1 ENSMUST00000043990.10 ENSMUST00000043990.11 ENSMUST00000043990.12 ENSMUST00000043990.13 ENSMUST00000043990.2 ENSMUST00000043990.3 ENSMUST00000043990.4 ENSMUST00000043990.5 ENSMUST00000043990.6 ENSMUST00000043990.7 ENSMUST00000043990.8 ENSMUST00000043990.9 NM_153799 Q3THV7 Q8K2D3 Yjdc uc009pvp.1 uc009pvp.2 uc009pvp.3 uc009pvp.4 Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity). Homodimer (via YjeF N-terminal domain). Forms a complex with DCP1A, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with DCP1A and DDX6. Interacts with ZFP36. Cytoplasm, P-body Note=Processing bodies (PB). The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with DDX6 (By similarity). Belongs to the EDC3 family. P-body RNA binding mRNA binding cytoplasm deadenylation-independent decapping of nuclear-transcribed mRNA cytoplasmic mRNA processing body assembly cytoplasmic ribonucleoprotein granule identical protein binding RNA phosphodiester bond hydrolysis, endonucleolytic phosphodiesterase decapping endonuclease activity uc009pvp.1 uc009pvp.2 uc009pvp.3 uc009pvp.4 
ENSMUST00000044000.12 4930447C04Rik ENSMUST00000044000.12 RIKEN cDNA 4930447C04 gene (from RefSeq NM_029444.2) ENSMUST00000044000.1 ENSMUST00000044000.10 ENSMUST00000044000.11 ENSMUST00000044000.2 ENSMUST00000044000.3 ENSMUST00000044000.4 ENSMUST00000044000.5 ENSMUST00000044000.6 ENSMUST00000044000.7 ENSMUST00000044000.8 ENSMUST00000044000.9 NM_029444 Q9CTN5 Q9D5F5 Q9D5Y9 S6OS1_MOUSE Six6os1 uc007nvv.1 uc007nvv.2 uc007nvv.3 Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination (PubMed:27796301, PubMed:33508233). Required for the appropriate processing of intermediate recombination nodules before crossover formation (PubMed:27796301). Interacts with SYCE1 (PubMed:27796301). Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis (PubMed:31437213). Chromosome Note=Component of the central element of the synaptonemal complex (PubMed:27796301). In spermatocytes, detected from zygonema to pachynema and localizes along synapsed lateral elements (PubMed:27796301). Loading to the central element of the synaptonemal complex is dependent on the assembly of the tripartite synaptonemal complex structure that occurs upon synapsis between homologous chromosomes (PubMed:27796301). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CTN5-1; Sequence=Displayed; Name=2; IsoId=Q9CTN5-2; Sequence=VSP_007121, VSP_007122; Most abundantly expressed in testis (PubMed:27796301). Also expressed in retina and skeletal muscle (PubMed:15703187). Mice develop normally but males and females are sterile due to defects in chromosome synapsis at meiotic prophase I (PubMed:27796301). Spermatogenesis proceeds normally up to prophase I until a massive apoptosis of spermatocytes takes place at stage IV (PubMed:27796301). Ovaries of female mice at 4 months of age display a lack of oocytes (PubMed:27796301). central element molecular_function chromosome DNA recombination synapsis multicellular organism development spermatogenesis meiotic DNA double-strand break processing involved in reciprocal meiotic recombination oogenesis regulation of sequence-specific DNA binding transcription factor activity meiotic cell cycle uc007nvv.1 uc007nvv.2 uc007nvv.3 
ENSMUST00000044003.14 Abca6 ENSMUST00000044003.14 ATP-binding cassette, sub-family A member 6, transcript variant 1 (from RefSeq NM_147218.2) A2A6R3 ABCA6_MOUSE ENSMUST00000044003.1 ENSMUST00000044003.10 ENSMUST00000044003.11 ENSMUST00000044003.12 ENSMUST00000044003.13 ENSMUST00000044003.2 ENSMUST00000044003.3 ENSMUST00000044003.4 ENSMUST00000044003.5 ENSMUST00000044003.6 ENSMUST00000044003.7 ENSMUST00000044003.8 ENSMUST00000044003.9 NM_147218 Q8BGH0 Q8BPT1 Q8K441 uc007mdj.1 uc007mdj.2 uc007mdj.3 uc007mdj.4 uc007mdj.5 Probable transporter which may play a role in macrophage lipid transport and homeostasis. Golgi apparatus membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K441-1; Sequence=Displayed; Name=2; IsoId=Q8K441-2; Sequence=VSP_020699, VSP_020700; Widely expressed with higher expression in heart, lung, brain, spleen and testis. Expressed during embryogenesis. Belongs to the ABC transporter superfamily. ABCA family. nucleotide binding lipid transporter activity ATP binding nucleoplasm lipid transport membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances intracellular membrane-bounded organelle transmembrane transport uc007mdj.1 uc007mdj.2 uc007mdj.3 uc007mdj.4 uc007mdj.5 
ENSMUST00000044005.14 Atf7ip2 ENSMUST00000044005.14 activating transcription factor 7 interacting protein 2, transcript variant 1 (from RefSeq NM_153123.2) ENSMUST00000044005.1 ENSMUST00000044005.10 ENSMUST00000044005.11 ENSMUST00000044005.12 ENSMUST00000044005.13 ENSMUST00000044005.2 ENSMUST00000044005.3 ENSMUST00000044005.4 ENSMUST00000044005.5 ENSMUST00000044005.6 ENSMUST00000044005.7 ENSMUST00000044005.8 ENSMUST00000044005.9 MCAF2_MOUSE Mcaf2 NM_153123 Psm2 Q3UL97 Q3UT16 Q4VIF3 Q8BPC5 Q9D4T8 uc007ydi.1 uc007ydi.2 uc007ydi.3 uc007ydi.4 Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (By similarity). Interacts with MBD1, SETDB1 and SP1. Probably forms a complex with SETDB1 and MBD1 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3UL97-1; Sequence=Displayed; Name=2; IsoId=Q3UL97-2; Sequence=VSP_024048, VSP_024049; Name=3; IsoId=Q3UL97-3; Sequence=VSP_024046, VSP_024047; Name=4; IsoId=Q3UL97-4; Sequence=VSP_024044, VSP_024045; Expressed in testis. Expressed in early mouse embryo, especially in the embryonic gonad from 11.5 dpc. Continuously expressed from newborn testis to adult. Belongs to the MCAF family. molecular_function nucleus biological_process uc007ydi.1 uc007ydi.2 uc007ydi.3 uc007ydi.4 
ENSMUST00000044007.3 Oxld1 ENSMUST00000044007.3 oxidoreductase like domain containing 1, transcript variant 1 (from RefSeq NM_025560.3) ENSMUST00000044007.1 ENSMUST00000044007.2 NM_025560 OXLD1_MOUSE Q9CR10 uc007mst.1 uc007mst.2 uc007mst.3 molecular_function mitochondrion biological_process uc007mst.1 uc007mst.2 uc007mst.3 
ENSMUST00000044009.14 Camk1d ENSMUST00000044009.14 calcium/calmodulin-dependent protein kinase ID, transcript variant 1 (from RefSeq NM_177343.4) ENSMUST00000044009.1 ENSMUST00000044009.10 ENSMUST00000044009.11 ENSMUST00000044009.12 ENSMUST00000044009.13 ENSMUST00000044009.2 ENSMUST00000044009.3 ENSMUST00000044009.4 ENSMUST00000044009.5 ENSMUST00000044009.6 ENSMUST00000044009.7 ENSMUST00000044009.8 ENSMUST00000044009.9 KCC1D_MOUSE NM_177343 Q3U450 Q80W64 Q8BW96 Q8BWI7 uc008ifp.1 uc008ifp.2 uc008ifp.3 uc008ifp.4 Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium- mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta (By similarity). Isoform 1 but not isoform 2 activates CREB1. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17; Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-180 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-180 results in several fold increase in total activity. Unlike CaMK4, may be unable to exhibit autonomous activity after Ca(2+)/calmodulin activation (By similarity). Cytoplasm Nucleus Note=Predominantly cytoplasmic. Nuclear upon activation. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha; IsoId=Q8BW96-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q8BW96-2; Sequence=VSP_012137; Name=3; IsoId=Q8BW96-3; Sequence=VSP_012136; Expressed ubiquitously with high levels in brain and low levels in kidney. Isoform 2 is highly expressed in brain compared to other tissues. In hematopoietic cell lines predominant expression was detected in T and EC cells. In EML cell line differentiation, expression increases 4 to 8 hours after treatment with all-trans retinoic acid (ATRA) and then declines after 24 hours of ATRA induction. Down-regulated upon cholesterol-rich diet. The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate. [Isoform 2]: Inactive. Does not activate CREB1. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. nucleotide binding catalytic activity protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity calmodulin binding ATP binding nucleus cytoplasm protein phosphorylation inflammatory response nervous system development metabolic process positive regulation of neuron projection development kinase activity phosphorylation transferase activity positive regulation of CREB transcription factor activity positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of phagocytosis regulation of dendrite development positive regulation of respiratory burst regulation of granulocyte chemotaxis positive regulation of neutrophil chemotaxis uc008ifp.1 uc008ifp.2 uc008ifp.3 uc008ifp.4 
ENSMUST00000044011.12 Fkbp1a ENSMUST00000044011.12 FK506 binding protein 1a, transcript variant 3 (from RefSeq NR_126058.1) ENSMUST00000044011.1 ENSMUST00000044011.10 ENSMUST00000044011.11 ENSMUST00000044011.2 ENSMUST00000044011.3 ENSMUST00000044011.4 ENSMUST00000044011.5 ENSMUST00000044011.6 ENSMUST00000044011.7 ENSMUST00000044011.8 ENSMUST00000044011.9 FKB1A_MOUSE Fkbp1 NR_126058 P26883 Q545E9 uc008ndy.1 uc008ndy.2 uc008ndy.3 uc008ndy.4 This gene is a member of the immunophilin family. The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor Ryr1. It also interacts with the type I TGF-beta receptor. Disruption of this gene in mouse causes severe ventricular defects. Pseudogenes of this gene have been defined on chromosomes 4, 10, 14, and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Inhibited by both FK506 and rapamycin. Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation (By similarity). Interacts with ACVR1B and SMAD7 (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (PubMed:18268335). Interacts directly with RYR2 and RYR3 (By similarity). Interacts directly with RYR1 (By similarity). Interacts with GLMN; rapamycin and FK506 abolish the interaction with GLMN in a dose dependent manner (By similarity). P26883; E9PZQ0: Ryr1; NbExp=2; IntAct=EBI-6379901, EBI-642079; Cytoplasm, cytosol Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the FKBP-type PPIase family. FKBP1 subfamily. protein peptidyl-prolyl isomerization negative regulation of protein phosphorylation heart morphogenesis peptidyl-prolyl cis-trans isomerase activity transforming growth factor beta receptor binding protein binding FK506 binding cytoplasm cytosol muscle contraction SMAD protein complex assembly drug binding response to iron ion membrane sarcoplasmic reticulum isomerase activity cytokine-mediated signaling pathway enzyme binding Z disc Hsp70 protein binding response to caffeine extrinsic component of organelle membrane positive regulation of protein ubiquitination positive regulation of protein binding negative regulation of phosphoprotein phosphatase activity regulation of protein localization regulation of activin receptor signaling pathway sarcoplasmic reticulum membrane type I transforming growth factor beta receptor binding T cell proliferation protein homodimerization activity intracellular membrane-bounded organelle axon terminus ion channel binding synapse SMAD binding activin binding regulation of immune response release of sequestered calcium ion into cytosol ventricular cardiac muscle tissue morphogenesis regulation of ryanodine-sensitive calcium-release channel activity heart trabecula formation chaperone-mediated protein folding supramolecular fiber organization cytoplasmic side of membrane regulation of amyloid precursor protein catabolic process amyloid fibril formation ryanodine receptor complex uc008ndy.1 uc008ndy.2 uc008ndy.3 uc008ndy.4 
ENSMUST00000044018.8 Noxa1 ENSMUST00000044018.8 NADPH oxidase activator 1, transcript variant 1 (from RefSeq NM_172204.4) A2AJA1 ENSMUST00000044018.1 ENSMUST00000044018.2 ENSMUST00000044018.3 ENSMUST00000044018.4 ENSMUST00000044018.5 ENSMUST00000044018.6 ENSMUST00000044018.7 NM_172204 NOXA1_MOUSE Q80SY2 Q8BU68 Q8CJ00 uc008iqh.1 uc008iqh.2 uc008iqh.3 uc008iqh.4 uc008iqh.5 Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes, hence reducing its ability to activate NOX1. Interacts (via N-terminus) with SH3PXD2A and SH3PXD2B; the interaction is direct. Interacts with RAC1 and NOXO1 (By similarity). Interacts with NOX1 and NCF1 (PubMed:16814099). Cytoplasm Cell membrane Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CJ00-1; Sequence=Displayed; Name=2; IsoId=Q8CJ00-2; Sequence=VSP_030337; Widely expressed with a tissue distribution similar to the one of NOX1. Detected in colon, uterus, prostate, small intestine, stomach, lung, thyroid, aorta, inner ear and salivary glands. Expressed in colon, small intestine and aortic smooth muscle cells (at protein level). The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function. The TPR repeats mediate interaction with RAC1. Belongs to the NCF2/NOXA1 family. cytoplasm cytosol plasma membrane superoxide metabolic process regulation of hydrogen peroxide metabolic process membrane superoxide-generating NADPH oxidase activator activity SH3 domain binding enzyme binding superoxide anion generation NADPH oxidase complex positive regulation of catalytic activity Rac GTPase binding regulation of respiratory burst uc008iqh.1 uc008iqh.2 uc008iqh.3 uc008iqh.4 uc008iqh.5 
ENSMUST00000044019.16 Slc41a3 ENSMUST00000044019.16 solute carrier family 41, member 3, transcript variant 1 (from RefSeq NM_027868.2) ENSMUST00000044019.1 ENSMUST00000044019.10 ENSMUST00000044019.11 ENSMUST00000044019.12 ENSMUST00000044019.13 ENSMUST00000044019.14 ENSMUST00000044019.15 ENSMUST00000044019.2 ENSMUST00000044019.3 ENSMUST00000044019.4 ENSMUST00000044019.5 ENSMUST00000044019.6 ENSMUST00000044019.7 ENSMUST00000044019.8 ENSMUST00000044019.9 G3X937 G3X937_MOUSE NM_027868 Slc41a3 uc009cxo.1 uc009cxo.2 uc009cxo.3 Acts as a magnesium transporter. Membrane ulti-pass membrane protein Belongs to the SLC41A transporter family. plasma membrane cation transport cation transmembrane transporter activity membrane integral component of membrane cation transmembrane transport uc009cxo.1 uc009cxo.2 uc009cxo.3 
ENSMUST00000044021.12 Slc19a2 ENSMUST00000044021.12 solute carrier family 19 (thiamine transporter), member 2, transcript variant 1 (from RefSeq NM_054087.3) ENSMUST00000044021.1 ENSMUST00000044021.10 ENSMUST00000044021.11 ENSMUST00000044021.2 ENSMUST00000044021.3 ENSMUST00000044021.4 ENSMUST00000044021.5 ENSMUST00000044021.6 ENSMUST00000044021.7 ENSMUST00000044021.8 ENSMUST00000044021.9 NM_054087 Q8BRH5 Q8R4Y1 Q9EQN9 S19A2_MOUSE Slc19a2 uc007did.1 uc007did.2 uc007did.3 High-affinity transporter for the intake of thiamine (PubMed:11481326, PubMed:11592824, PubMed:12393806, PubMed:22194418, PubMed:12031504, PubMed:24961373, PubMed:35724964). Essential for spermatogenesis (PubMed:14567973, PubMed:14738878). Mediates H(+)- dependent pyridoxine transport (PubMed:35512554, PubMed:35724964). Reaction=H(+)(in) + thiamine(out) = H(+)(out) + thiamine(in); Xref=Rhea:RHEA:71271, ChEBI:CHEBI:15378, ChEBI:CHEBI:18385; Evidence= [Isoform 1]: Reaction=H(+)(in) + thiamine(out) = H(+)(out) + thiamine(in); Xref=Rhea:RHEA:71271, ChEBI:CHEBI:15378, ChEBI:CHEBI:18385; Evidence=; [Isoform 2]: Reaction=H(+)(in) + thiamine(out) = H(+)(out) + thiamine(in); Xref=Rhea:RHEA:71271, ChEBI:CHEBI:15378, ChEBI:CHEBI:18385; Evidence=; Reaction=n H(+)(out) + pyridoxine(out) = n H(+)(in) + pyridoxine(in); Xref=Rhea:RHEA:76203, ChEBI:CHEBI:15378, ChEBI:CHEBI:16709; Evidence=; Kinetic parameters: KM=170 uM for thiamine ; Vmax=760 pmol/min/mg enzyme for thiamine uptake ; Cell membrane ulti-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EQN9-1; Sequence=Displayed; Name=2; IsoId=Q9EQN9-2; Sequence=VSP_059029; Expressed in liver (PubMed:24961373). Expressed in cochlear hair cells and duodenum (at protein level) (PubMed:11592824). Detected in pancreatic acinar cells (at protein level) (PubMed:22194418). Also expressed strongly in pancreatic islet cells (PubMed:22194418). Expressed in the testis (PubMed:14738878). [Isoform 1]: Very highly expressed in liver, and also detected at lower levels in heart, testis, kidney, brain and spleen. [Isoform 2]: Expressed at low levels in liver and spleen. At embryonic stage 16.5 dpc detected in intestinal enterocytes, pancreatic acinar cells, and cochlear hair cells (at protein level). In newborn mice, detected in brain, kidney, liver and intestine (at protein level). Induced in a TP53/p53-dependent manner upon DNA damage. Males are infertile with reduced testis size and aspermia (PubMed:14567973, PubMed:14738878). Spermatogenesis fails at the pachytene spermatid stage with apoptosis of germ cells (PubMed:14567973, PubMed:14738878). When fed on a thiamine-free diet, animals develop additional phenotypes including diabetes mellitus, profound hearing loss, and defective hematopoiesis (PubMed:12393806, PubMed:14567973, PubMed:16642288). Pancreatic morphology appears to be normal although insulin secretion is significantly impaired (PubMed:12393806). Erythroid precursors in the bone marrow are almost completely absent leading to loss of reticulocytes in the peripheral blood (PubMed:14567973). The hearing loss phenotype is specifically associated with loss of cochlear inner hair cells (PubMed:16642288). These phenotypes can be reversed in many cases by re-introduction of a high thiamine diet (PubMed:12393806, PubMed:14567973, PubMed:16642288). Thiamine uptake by pancreatic acinar cells from knockout mice was found to be significantly lower than uptake by pancreatic acinar cells of the wild-type littermates (PubMed:22194418). Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. plasma membrane thiamine transmembrane transporter activity thiamine transport membrane integral component of membrane vitamin transport transmembrane transport thiamine transmembrane transport vitamin transmembrane transporter activity uc007did.1 uc007did.2 uc007did.3 
ENSMUST00000044031.4 Rag2 ENSMUST00000044031.4 recombination activating gene 2 (from RefSeq NM_009020.4) ENSMUST00000044031.1 ENSMUST00000044031.2 ENSMUST00000044031.3 NM_009020 Q542D1 Q542D1_MOUSE Rag2 uc008lhj.1 uc008lhj.2 uc008lhj.3 Nucleus Belongs to the RAG2 family. DNA binding nucleus DNA recombination uc008lhj.1 uc008lhj.2 uc008lhj.3 
ENSMUST00000044038.10 Kyat1 ENSMUST00000044038.10 kynurenine aminotransferase 1, transcript variant 3 (from RefSeq NM_001356475.1) Ccbl1 ENSMUST00000044038.1 ENSMUST00000044038.2 ENSMUST00000044038.3 ENSMUST00000044038.4 ENSMUST00000044038.5 ENSMUST00000044038.6 ENSMUST00000044038.7 ENSMUST00000044038.8 ENSMUST00000044038.9 KAT1_MOUSE Kat NM_001356475 Q8BTY1 Q8BY27 uc008jbs.1 uc008jbs.2 uc008jbs.3 Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Reaction=2-oxoglutarate + L-kynurenine = H2O + kynurenate + L- glutamate; Xref=Rhea:RHEA:65560, ChEBI:CHEBI:15377, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454; EC=2.6.1.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65561; Evidence=; Reaction=3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L- phenylalanine; Xref=Rhea:RHEA:17593, ChEBI:CHEBI:16769, ChEBI:CHEBI:18005, ChEBI:CHEBI:58095, ChEBI:CHEBI:58359; EC=2.6.1.64; Evidence=; Reaction=an S-substituted L-cysteine + H2O = a thiol + NH4(+) + pyruvate; Xref=Rhea:RHEA:18121, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29256, ChEBI:CHEBI:58717; EC=4.4.1.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18122; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2. Homodimer. Cytoplasm, cytosol Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. catalytic activity nucleoplasm cytoplasm mitochondrion cytosol pyruvate metabolic process cellular modified amino acid metabolic process transaminase activity biosynthetic process response to bacterium kynurenine-oxoglutarate transaminase activity transferase activity lyase activity pyridoxal phosphate binding protein homodimerization activity glutamine-phenylpyruvate transaminase activity cysteine-S-conjugate beta-lyase activity kynurenine metabolic process L-glutamine aminotransferase activity L-kynurenine metabolic process L-kynurenine catabolic process uc008jbs.1 uc008jbs.2 uc008jbs.3 
ENSMUST00000044039.2 Lrrd1 ENSMUST00000044039.2 leucine rich repeats and death domain containing 1 (from RefSeq NM_172879.3) B2RU96 ENSMUST00000044039.1 LRRD1_MOUSE NM_172879 Q8C0R9 uc008whx.1 uc008whx.2 uc008whx.3 molecular_function uc008whx.1 uc008whx.2 uc008whx.3 
ENSMUST00000044043.4 Cox5b-ps ENSMUST00000044043.4 Cox5b-ps (from geneSymbol) Cox5b Cox5b-ps ENSMUST00000044043.1 ENSMUST00000044043.2 ENSMUST00000044043.3 Q9D881 Q9D881_MOUSE uc288lex.1 uc288lex.2 uc288lex.3 molecular_function cytochrome-c oxidase activity cellular_component mitochondrial envelope biological_process electron transport chain hydrogen ion transmembrane transport uc288lex.1 uc288lex.2 uc288lex.3 
ENSMUST00000044048.8 Hspb6 ENSMUST00000044048.8 heat shock protein, alpha-crystallin-related, B6, transcript variant 1 (from RefSeq NM_001012401.3) ENSMUST00000044048.1 ENSMUST00000044048.2 ENSMUST00000044048.3 ENSMUST00000044048.4 ENSMUST00000044048.5 ENSMUST00000044048.6 ENSMUST00000044048.7 Gm479 HSPB6_MOUSE NM_001012401 Q5EBG6 uc009gew.1 uc009gew.2 uc009gew.3 Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. Homodimer. Small heat shock proteins form high molecular mass oligomers containing variable number of monomers; these oligomers display a very flexible quaternary structure easily exchanging their subunits. Heterooligomer with HSPB1; formed through oligomerization of HSPB1:HSBP6 dimers; subunit exchange leads to formation of at least two different heterooligomeric complexes, differing in variable quantities of HSPB1 and HSPB6 homodimers in addition to HSPB1:HSPB6 heterodimers. Heterooligomer with CRYAB; large heterooligomers consist of CRYAB homodimers and HSPB5:HSPB6 heterodimers but lacking HSPB6 homodimers. Interacts with BAG3. Interacts (phosphorylated) with YWHAZ. Interacts with PDE4A and PDE4D; required for maintenance of the non- phosphorylated state of HSPB6 under basal conditions. Interacts with KDR. Interacts with PRKD1. Cytoplasm Nucleus Secreted Note=Translocates to nuclear foci during heat shock. Phosphorylated at Ser-16 by PKA and probably PKD1K; required to protect cardiomyocytes from apoptosis. Belongs to the small heat shock protein (HSP20) family. structural constituent of eye lens extracellular region nucleus cytoplasm regulation of muscle contraction negative regulation of cardiac muscle cell apoptotic process protein homodimerization activity positive regulation of angiogenesis unfolded protein binding chaperone binding chaperone-mediated protein folding uc009gew.1 uc009gew.2 uc009gew.3 
ENSMUST00000044051.6 Timm8b ENSMUST00000044051.6 translocase of inner mitochondrial membrane 8B (from RefSeq NM_013897.3) Ddp2 ENSMUST00000044051.1 ENSMUST00000044051.2 ENSMUST00000044051.3 ENSMUST00000044051.4 ENSMUST00000044051.5 NM_013897 P62077 Q3TF77 Q9QUT4 TIM8B_MOUSE Tim8b uc009pjw.1 uc009pjw.2 uc009pjw.3 uc009pjw.4 Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). Heterohexamer; possibly composed of 3 copies of TIMM8B and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). Belongs to the small Tim family. mitochondrion mitochondrial inner membrane mitochondrial intermembrane space protein transport membrane metal ion binding chaperone-mediated protein transport uc009pjw.1 uc009pjw.2 uc009pjw.3 uc009pjw.4 
ENSMUST00000044053.13 Shprh ENSMUST00000044053.13 SNF2 histone linker PHD RING helicase, transcript variant 1 (from RefSeq NM_001077707.1) ENSMUST00000044053.1 ENSMUST00000044053.10 ENSMUST00000044053.11 ENSMUST00000044053.12 ENSMUST00000044053.2 ENSMUST00000044053.3 ENSMUST00000044053.4 ENSMUST00000044053.5 ENSMUST00000044053.6 ENSMUST00000044053.7 ENSMUST00000044053.8 ENSMUST00000044053.9 NM_001077707 Q7TPQ3 Q7TQ27 Q7TQ28 Q7TQ29 Q8BKE2 Q8BUW0 Q922Q3 SHPRH_MOUSE uc007ejq.1 uc007ejq.2 uc007ejq.3 uc007ejq.4 E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly- ubiquitin chains linked through 'Lys-63'. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Homodimer. Interacts with HLTF, PCNA, UBE2N and RAD18. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q7TPQ3-1; Sequence=Displayed; Name=2; Synonyms=A; IsoId=Q7TPQ3-2; Sequence=VSP_024768; Name=3; IsoId=Q7TPQ3-3; Sequence=VSP_024766, VSP_024767; Name=4; Synonyms=C; IsoId=Q7TPQ3-5; Sequence=VSP_024769, VSP_024770; Broadly expressed (at protein level). The RING finger mediates E3 ubiquitin ligase activity. Belongs to the SNF2/RAD54 helicase family. Sequence=AAO26655.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; nucleotide binding protein polyubiquitination nucleosome DNA binding helicase activity ubiquitin-protein transferase activity ATP binding cellular_component nucleus DNA repair nucleosome assembly cellular response to DNA damage stimulus protein ubiquitination transferase activity hydrolase activity ubiquitin protein ligase binding metal ion binding ubiquitin protein ligase activity uc007ejq.1 uc007ejq.2 uc007ejq.3 uc007ejq.4 
ENSMUST00000044058.11 Mul1 ENSMUST00000044058.11 mitochondrial ubiquitin ligase activator of NFKB 1 (from RefSeq NM_026689.3) A2AM82 A2AM84 B5M498 ENSMUST00000044058.1 ENSMUST00000044058.10 ENSMUST00000044058.2 ENSMUST00000044058.3 ENSMUST00000044058.4 ENSMUST00000044058.5 ENSMUST00000044058.6 ENSMUST00000044058.7 ENSMUST00000044058.8 ENSMUST00000044058.9 Gide MUL1_MOUSE NM_026689 Q3TDK4 Q8BHF2 Q8VCM5 Q9DCV9 uc008vky.1 uc008vky.2 uc008vky.3 Exhibits weak E3 ubiquitin-protein ligase activity (By similarity). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'- linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation (By similarity). Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-27' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion (By similarity). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (By similarity). Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (By similarity). Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (By similarity). Inhibits cell growth (By similarity). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase- dependent apoptosis (By similarity). Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response (By similarity). Can mediate RIGI sumoylation and disrupt its polyubiquitination (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Protein modification; protein sumoylation. Homooligomer. Interacts with MAP3K7/TAK1. Interacts with UBC9. Interacts with and sumoylates DNM1L. Interacts with MAVS. Interacts with TP53 (via N-terminus); the interaction leads to ubiquitination and proteasomal degradation of TP53. Mitochondrion outer membrane ; Multi-pass membrane protein Peroxisome Note=Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VCM5-1; Sequence=Displayed; Name=2; IsoId=Q8VCM5-2; Sequence=VSP_034454, VSP_034455; Name=3; IsoId=Q8VCM5-3; Sequence=VSP_034453; Expressed in cortical neurons (at protein level). The zinc finger domain is required for E3 ligase activity. Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. mitochondrial fission ubiquitin-protein transferase activity mitochondrion mitochondrial outer membrane peroxisome apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process organelle organization activation of JUN kinase activity negative regulation of mitochondrial fusion regulation of mitochondrion organization membrane integral component of membrane protein ubiquitination transferase activity protein sumoylation SUMO transferase activity negative regulation of cell growth axon integral component of mitochondrial outer membrane ubiquitin protein ligase binding regulation of protein stability protein destabilization positive regulation of protein sumoylation identical protein binding neuronal cell body positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of innate immune response metal ion binding negative regulation of defense response to virus by host protein stabilization mitochondrion localization regulation of mitochondrial membrane potential negative regulation of protein kinase B signaling negative regulation of type I interferon-mediated signaling pathway cellular response to exogenous dsRNA negative regulation of chemokine (C-C motif) ligand 5 production positive regulation of mitochondrial fission regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway positive regulation of dendrite extension positive regulation of mitophagy in response to mitochondrial depolarization uc008vky.1 uc008vky.2 uc008vky.3 
ENSMUST00000044059.5 Atoh7 ENSMUST00000044059.5 atonal bHLH transcription factor 7, transcript variant 1 (from RefSeq NM_016864.3) ATOH7_MOUSE Ath5 Atoh7 ENSMUST00000044059.1 ENSMUST00000044059.2 ENSMUST00000044059.3 ENSMUST00000044059.4 NM_016864 Q9Z2E5 uc007fjv.1 uc007fjv.2 uc007fjv.3 Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (PubMed:33712461). Dimerization with TCF3 isoform E47 may be required in certain situations (By similarity). Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes (PubMed:33712461). Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract (PubMed:11493566, PubMed:11156601, PubMed:12451142, PubMed:33712461). Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription (PubMed:33712461). Required for retinal circadian rhythm photoentrainment (PubMed:12451142, PubMed:26392540). Plays a role in brainstem auditory signaling and binaural processing (PubMed:17977745). Forms a heterodimer with TCF3 isoform E47; interaction may be required for DNA-binding in certain situations. Nucleus Perikaryon Cell projection, axon Expressed in retinal ganglion cells (PubMed:26392540). Expressed in the cerebellum, trapezoid body, ventral nucleus of the lateral lamniscus and in areas of the auditory hindbrain such as the cochlear nucleus, lateral superior olive and medial nucleus of the trapezoid body (PubMed:17977745). Expressed in the modiolar nerve root and in the cochlear in a small group of bushy neurons within the acoustic nerve (PubMed:17977745). Expressed weakly in the sensory epithelia of the saccule and utricle (PubMed:17977745). Expression initiates at 11 dpc in the central optic cup and is detected in retinal progenitor cells until birth (PubMed:9806930). In addition to the eye, only expressed in the developing tenth cranial ganglion between 13.5 dpc and 15.5 dpc (PubMed:9806930). Expressed in the retina and faintly expressed in the caudal rhombic lip and rostral rhombic lip at 12.5 dpc (PubMed:17977745). Expressed in the presumptive ventral cochlear nucleus and in initial axons emerging from the cochlear nucleus and extending via the trapezoid body towards the ipsilateral lateral superior olive at 14.5 dpc (PubMed:17977745). Expressed in the cochlear duct epithelium between 14.5 dpc and 17.5 dpc (PubMed:17977745). Expressed in the retina at 16.5 dpc (PubMed:17977745). Expressed in the cochlear nucleus at 16.5 dpc and P8 (PubMed:17977745). Abundantly expressed in the ventral cochlear nucleus and axons originating from these cells that form branches in the lateral superior olive at 18.5dpc (PubMed:17977745). Mice are viable and fertile but display multiple optic abnormalities resulting in blindness (PubMed:11493566, PubMed:11156601, PubMed:12451142, PubMed:26392540, PubMed:33712461). Normal hindbrain morphology, however mice show disruption of brainstem auditory signaling and binaural processing (PubMed:17977745). Loss of retinal circadian rhythm photoentrainment, and decreased expression of Opn5 (PubMed:12451142, PubMed:26392540). Loss of the retinohypothalamic tract connecting the retina to the suprachiasmatic nuclei (PubMed:12451142). Loss of axon bundles, optic nerves and chiasmata, with a decreased thickness of the retinal inner plexiform layer and inner nuclear layer (PubMed:11493566). Increase in cone photoreceptors and decrease in dopaminergic amacrine cells in the ganglion cell layer (PubMed:11493566, PubMed:33712461). Loss of retinal Pou4f2-expressing retinal ganglion cells resulting in a decrease in the thickness of the retinal cell layer and loss of the nerve fiber layer (PubMed:11493566, PubMed:11156601). Significant reduction in RGCs and compensatory increase in cone photoreceptors and neurogenic progenitor cells at 14.5 dpc (PubMed:33712461). The 1% of RGCs that survive into adulthood show severe axon guidance defects and extend into the retina instead of targeting the optic disk with only a few forming a rudimentary optic nerve (PubMed:33712461). No observable RGC axonal terminals in the brain and persistent retinal hyaloid vasculature into adulthood (PubMed:33712461). In Atoh7 and Bax double knockout mice, significant reduction in RGCs and compensatory increase in cone photoreceptor cells and neurogenic retinal progenitor cells at 14.5 dpc, however there is no difference in the number of RGCs derived from Atoh7-expressing cells and cone photoreceptors during adulthood (PubMed:33712461). Reduced light spatial receptive fields, slower light-driven responses and reduced pupillary light response (PubMed:33712461). neural retina development DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development nervous system development circadian rhythm entrainment of circadian clock optic nerve development cell differentiation protein dimerization activity uc007fjv.1 uc007fjv.2 uc007fjv.3 
ENSMUST00000044060.14 Cd209c ENSMUST00000044060.14 CD209c antigen (from RefSeq NM_130903.4) C209C_MOUSE ENSMUST00000044060.1 ENSMUST00000044060.10 ENSMUST00000044060.11 ENSMUST00000044060.12 ENSMUST00000044060.13 ENSMUST00000044060.2 ENSMUST00000044060.3 ENSMUST00000044060.4 ENSMUST00000044060.5 ENSMUST00000044060.6 ENSMUST00000044060.7 ENSMUST00000044060.8 ENSMUST00000044060.9 NM_130903 Q0VB37 Q91ZW9 uc009ksw.1 uc009ksw.2 Probable pathogen-recognition receptor. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified. Name=Functional Glycomics Gateway - Glycan Binding; Note=SIGNR2; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_163"; mannose binding cellular_component biological_process carbohydrate binding metal ion binding uc009ksw.1 uc009ksw.2 
ENSMUST00000044078.10 Entpd8 ENSMUST00000044078.10 Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. (from UniProt Q8K0L2) A2AJ99 BC031143 ENSMUST00000044078.1 ENSMUST00000044078.2 ENSMUST00000044078.3 ENSMUST00000044078.4 ENSMUST00000044078.5 ENSMUST00000044078.6 ENSMUST00000044078.7 ENSMUST00000044078.8 ENSMUST00000044078.9 ENTP8_MOUSE Q6UQ22 Q8K0L2 uc009vca.1 uc009vca.2 uc009vca.3 Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. Reaction=a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:36795, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.5; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Ca(2+) or Mg(2+). Has lower efficiency with Mg(2+). ; Kinetic parameters: KM=13 uM for ATP ; KM=41 uM for ADP ; KM=47 uM for UTP ; KM=171 uM for UDP ; pH dependence: Optimum pH is 5.5-8.0. ; Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K0L2-1; Sequence=Displayed; Name=2; IsoId=Q8K0L2-2; Sequence=VSP_028560, VSP_028561; Expressed in liver, jejunum and kidney. The transmembranous domains are involved in regulation of enzyme activity. N-glycosylated. Belongs to the GDA1/CD39 NTPase family. nucleotide binding ATP binding plasma membrane nucleoside monophosphate biosynthetic process nucleoside diphosphate biosynthetic process membrane integral component of membrane hydrolase activity nucleoside-diphosphatase activity nucleoside-triphosphatase activity metal ion binding 8-oxo-dGTP phosphohydrolase activity uc009vca.1 uc009vca.2 uc009vca.3 
ENSMUST00000044083.9 Dapk1 ENSMUST00000044083.9 death associated protein kinase 1, transcript variant 2 (from RefSeq NM_134062.2) DAPK1_MOUSE ENSMUST00000044083.1 ENSMUST00000044083.2 ENSMUST00000044083.3 ENSMUST00000044083.4 ENSMUST00000044083.5 ENSMUST00000044083.6 ENSMUST00000044083.7 ENSMUST00000044083.8 NM_134062 Q80YE6 Q80YE7 Q8R341 Q8VDN6 Q9CSD4 Q9JJP7 uc007qvo.1 uc007qvo.2 uc007qvo.3 Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3 (By similarity). Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by Ca(2+)/calmodulin. Regulated by a locking mechanism, involving autophosphorylation at Ser-308 and calmodulin binding. In the inactive state, Ser-308 is phosphorylated. Activation involves its dephosphorylation and a release-of- autoinhibition mechanism where binding of calmodulin induces a conformational change that relieves the steric block of the active site by the autoinhibitory domain. Activity is modulated by UNC5B and NTN1. UNC5B activates it by inhibiting the phosphorylation at Ser-308, whereas NTN1 inhibits UNC5B-mediated activation of DAPK1. Endoplasmic- stress activates by causing Ser-308 dephosphorylation. Interacts with KLHL20 (By similarity). Interacts (via death domain) with MAPK1 and MAPK3 (By similarity). Interacts with MAP1B (via N-terminus) (By similarity). Interacts with PRKD1 in an oxidative stress-regulated manner (By similarity). Interacts with PIN1, PDCD6, BECN1, TSC2 and STX1A (By similarity). Interacts (via kinase domain) with DAPK3 (via kinase domain) (By similarity). Interacts with GRINB (PubMed:20141836). Interacts (via death domain) with UNC5B (via death domain) (PubMed:15729359). Interacts with UNC5C (via death domain) (By similarity). Q80YE7; Q01097: Grin2b; NbExp=8; IntAct=EBI-2584874, EBI-400125; Event=Alternative splicing; Named isoforms=2; Name=1 ; Synonyms=Beta; IsoId=Q80YE7-1; Sequence=Displayed; Name=2 ; Synonyms=Alpha; IsoId=Q80YE7-2; Sequence=VSP_050629; High levels in bladder, uterus, vas deferens, lung, liver and kidney. The autoinhibitory domain sterically blocks the substrate peptide-binding site by making both hydrophobic and electrostatic contacts with the kinase core. Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex, leading to its degradation by the proteasome. In response to mitogenic stimulation (PMA or EGF), phosphorylated at Ser-289; phosphorylation suppresses DAPK1 pro-apoptotic function. Autophosphorylation at Ser-308 inhibits its catalytic activity. Phosphorylation at Ser-734 by MAPK1 increases its catalytic activity and promotes cytoplasmic retention of MAPK1. Endoplasmic-stress can cause dephosphorylation at Ser-308. Mice are protected against cerebral ischemic neuronal death. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. Sequence=AAH21490.1; Type=Erroneous initiation; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity protein binding calmodulin binding ATP binding GTP binding nucleus cytoplasm cytosol plasma membrane regulation of translation protein phosphorylation apoptotic process signal transduction extrinsic apoptotic signaling pathway via death domain receptors positive regulation of autophagy actin cytoskeleton kinase activity phosphorylation transferase activity syntaxin-1 binding negative regulation of translation intracellular signal transduction identical protein binding negative regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein autophosphorylation cellular response to interferon-gamma cellular response to hydroperoxide apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of N-methyl-D-aspartate selective glutamate receptor activity uc007qvo.1 uc007qvo.2 uc007qvo.3 
ENSMUST00000044089.4 Asb17 ENSMUST00000044089.4 ankyrin repeat and SOCS box-containing 17 (from RefSeq NM_025758.4) ASB17_MOUSE ENSMUST00000044089.1 ENSMUST00000044089.2 ENSMUST00000044089.3 NM_025758 Q8VHP9 Q9CUF9 uc008rty.1 uc008rty.2 uc008rty.3 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Specifically expressed in testis (PubMed:15460110). Localizes to spermatogenic cells in testis, with highest expression in round spermatids and condensing spermatids and lower expression in pachytene spermatocytes (PubMed:15204681, PubMed:15460110). Expressed in testis from 3 weeks of age onwards, reaching maximum levels by 4 to 5 weeks of age. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Belongs to the ankyrin SOCS box (ASB) family. molecular_function cellular_component biological_process protein ubiquitination intracellular signal transduction uc008rty.1 uc008rty.2 uc008rty.3 
ENSMUST00000044094.6 Hsd3b5 ENSMUST00000044094.6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 (from RefSeq NM_008295.2) 3BHS5_MOUSE ENSMUST00000044094.1 ENSMUST00000044094.2 ENSMUST00000044094.3 ENSMUST00000044094.4 ENSMUST00000044094.5 Hsd3b5 NM_008295 Q61694 Q91X27 uc290hys.1 uc290hys.2 Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase. Reaction=a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH; Xref=Rhea:RHEA:34787, ChEBI:CHEBI:15378, ChEBI:CHEBI:36836, ChEBI:CHEBI:47788, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.270; Evidence=; Reaction=5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta- hydroxy-5alpha-androstan-3-one + H(+) + NADPH; Xref=Rhea:RHEA:16297, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:18329, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.210; Evidence=; Kinetic parameters: KM=0.47 uM for dihydrotestosterone ; Steroid metabolism. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Expressed in the male liver, starting in late puberty. Belongs to the 3-beta-HSD family. 3-keto sterol reductase activity 3-beta-hydroxy-delta5-steroid dehydrogenase activity steroid binding mitochondrion mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process steroid metabolic process C21-steroid hormone metabolic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor hippocampus development mitochondrial membrane response to stilbenoid intracellular membrane-bounded organelle 5alpha-androstane-3beta,17beta-diol dehydrogenase activity response to corticosterone oxidation-reduction process uc290hys.1 uc290hys.2 
ENSMUST00000044103.6 Rpl39l ENSMUST00000044103.6 ribosomal protein L39-like (from RefSeq NM_026594.2) ENSMUST00000044103.1 ENSMUST00000044103.2 ENSMUST00000044103.3 ENSMUST00000044103.4 ENSMUST00000044103.5 NM_026594 Q9CQD0 RL39L_MOUSE Rpl39l uc007yde.1 uc007yde.2 Male germ cell-specific component of the ribosome, which is required for the formation of sperm and male fertility (PubMed:34825148, PubMed:36517592). Replaces the RPL39 paralog in the ribosome of male germ cells (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:34428590, PubMed:36517592). The male germ cell- specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome (PubMed:36517592). It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm (PubMed:36517592). Component of a male germ cell-specific 60S large ribosomal subunit (LSU), which contains RPL10L and RPL39L, instead of RPL10 and RPL39 paralogs (PubMed:36517592). The composition of the rest of the complex is similar to classical ribosomes (PubMed:36517592). Cytoplasm Highly expressed in spermatocytes and spermatids (PubMed:34825148, PubMed:36517592). Highly expressed in embryonic stem cells (PubMed:24452241). Defective sperm formation, resulting in substantially reduced male fertility (PubMed:34825148, PubMed:36517592). Male mice show smaller testis sizes, lower testis/body weight ratio, increased ratios of abnormal sperm head and tail and severe subfertility with significantly fewer cumulative live pups born compared with wild-type mice (PubMed:36517592). The sperm count, motility and progressive motility are reduced (PubMed:36517592). Female mice display normal fertility (PubMed:36517592). Belongs to the eukaryotic ribosomal protein eL39 family. Name=Protein Spotlight; Note=A shrewd tweak - Issue 258 of May 2023; URL="https://www.proteinspotlight.org/back_issues/258/"; structural constituent of ribosome ribosome translation cytosolic large ribosomal subunit uc007yde.1 uc007yde.2 
ENSMUST00000044105.9 Tspan10 ENSMUST00000044105.9 tetraspanin 10 (from RefSeq NM_145363.2) ENSMUST00000044105.1 ENSMUST00000044105.2 ENSMUST00000044105.3 ENSMUST00000044105.4 ENSMUST00000044105.5 ENSMUST00000044105.6 ENSMUST00000044105.7 ENSMUST00000044105.8 NM_145363 Q3UGA5 Q3UGA5_MOUSE Tspan10 uc007msr.1 uc007msr.2 uc007msr.3 uc007msr.4 Membrane ; Multi- pass membrane protein membrane integral component of membrane uc007msr.1 uc007msr.2 uc007msr.3 uc007msr.4 
ENSMUST00000044106.6 Psmd7 ENSMUST00000044106.6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (from RefSeq NM_010817.2) ENSMUST00000044106.1 ENSMUST00000044106.2 ENSMUST00000044106.3 ENSMUST00000044106.4 ENSMUST00000044106.5 Mov-34 Mov34 NM_010817 P26516 PSMD7_MOUSE Q3TW61 Q8C0I8 uc009nhz.1 uc009nhz.2 uc009nhz.3 uc009nhz.4 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD7, a base containing 6 ATPases and few additional components. Within the complex, PSMD7 interacts with subunit PSMD4 through their respective MPN domain. Interacts with TRIM5. Note=Disruption of the Mov-34 locus is a recessive embryonic lethal mutation. Does not bind a metal ion. Belongs to the peptidase M67A family. proteasome complex nucleoplasm proteasome regulatory particle protein homodimerization activity proteasome-mediated ubiquitin-dependent protein catabolic process uc009nhz.1 uc009nhz.2 uc009nhz.3 uc009nhz.4 
ENSMUST00000044111.10 Rras ENSMUST00000044111.10 related RAS viral (r-ras) oncogene, transcript variant 1 (from RefSeq NM_009101.4) ENSMUST00000044111.1 ENSMUST00000044111.2 ENSMUST00000044111.3 ENSMUST00000044111.4 ENSMUST00000044111.5 ENSMUST00000044111.6 ENSMUST00000044111.7 ENSMUST00000044111.8 ENSMUST00000044111.9 NM_009101 Q3U1N3 Q3U1N3_MOUSE Rras uc009gss.1 uc009gss.2 uc009gss.3 nucleotide binding leukocyte differentiation GTPase activity GTP binding signal transduction membrane GDP binding macromolecular complex binding positive regulation of angiogenesis regulation of protein kinase B signaling face morphogenesis regulation of ERK1 and ERK2 cascade uc009gss.1 uc009gss.2 uc009gss.3 
ENSMUST00000044113.12 Ago2 ENSMUST00000044113.12 argonaute RISC catalytic subunit 2 (from RefSeq NM_153178.5) A1A563 AGO2_MOUSE ENSMUST00000044113.1 ENSMUST00000044113.10 ENSMUST00000044113.11 ENSMUST00000044113.2 ENSMUST00000044113.3 ENSMUST00000044113.4 ENSMUST00000044113.5 ENSMUST00000044113.6 ENSMUST00000044113.7 ENSMUST00000044113.8 ENSMUST00000044113.9 Eif2c2 Kiaa4215 NM_153178 Q4VAB3 Q571J6 Q8CJG0 uc007wbu.1 uc007wbu.2 uc007wbu.3 uc007wbu.4 Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7- methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P- bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up- regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF- alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. Regulates lymphoid and erythroid development and function, and this is independent of endonuclease activity. Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.n2; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Interacts with DICER1 through its Piwi domain and with TARBP2 during assembly of the RNA-induced silencing complex (RISC). Together, DICER1, AGO2 and TARBP2 constitute the trimeric RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC). Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Note however that the term RISC has also been used to describe the trimeric RLC/miRLC. The formation of RISC complexes containing siRNAs rather than miRNAs appears to occur independently of DICER1 (PubMed:16357216). Interacts with AGO1. Also interacts with DDB1, DDX5, DDX6, DDX20, DHX30, DHX36, DDX47, DHX9, ELAVL, FXR1, GEMIN4, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, PABPC1, PRMT5, P4HA1, P4HB, RBM4, SART3, TNRC6A, TNRC6B, UPF1 and YBX1. Interacts with the P-body components DCP1A and XRN1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with RBM4; the interaction is modulated under stress-induced conditions, occurs under both cell proliferation and differentiation conditions and in an RNA- and phosphorylation-independent manner. Interacts with LIMD1, WTIP and AJUBA (By similarity). Interacts with TRIM71 (PubMed:19898466, PubMed:22508726, PubMed:22735451). Interacts with APOBEC3G in an RNA- dependent manner. Interacts with APOBEC3A, APOBEC3C, APOBEC3F and APOBEC3H. Interacts with DICER1, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). Interacts with FMR1. Interacts with ZFP36 (By similarity). Interacts with RC3H1; the interaction is RNA independent (PubMed:25697406). Interacts with ARB2A (PubMed:29311329). Found in a complex composed of AGO2, CHD7 and ARB2A (PubMed:29311329). Interacts with SND1 and SYT11 (PubMed:24882364). Interacts with CLNK (PubMed:26009488). Interacts with GARRE1 (By similarity). Q8CJG0; Q4VGL6: Rc3h1; NbExp=2; IntAct=EBI-528299, EBI-2366263; Q8CJG0; Q9UPY3: DICER1; Xeno; NbExp=2; IntAct=EBI-528299, EBI-395506; Q8CJG0; P04156: PRNP; Xeno; NbExp=2; IntAct=EBI-528299, EBI-977302; Q8CJG0; P04273: PRNP; Xeno; NbExp=2; IntAct=EBI-528299, EBI-986426; Q8CJG0; Q9HCJ0: TNRC6C; Xeno; NbExp=3; IntAct=EBI-528299, EBI-6507625; Cytoplasm, P-body cleus Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8. Ubiquitous expression in 9.5 day embryos with highest levels in forebrain, heart, limb buds, and branchial arches. The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp- Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH). Hydroxylated. 4-hydroxylation appears to enhance protein stability but is not required for miRNA-binding or endonuclease activity. Ubiquitinated on surface-exposed lysines by a SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 during target- directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). Ubiquitination by the SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 leads to its subsequent degradation, thereby exposing miRNAs for degradation. ZSWIM8 recognizes and binds AGO2 when it is engaged with a TDMD target. Phosphorylation at Ser-388 by AKT3; leads to up-regulate translational repression of microRNA target and down-regulate endonucleolytic cleavage. A phosphorylation cycle of C-terminal serine cluster (Ser-825-Ser- 835) regulates the release of target mRNAs. Target-binding leads to phosphorylation of these residues by CSNK1A1, which reduces the affinity of AGO2 for mRNA and enables target release. The ANKRD52-PPP6C phosphatase complex dephosphorylates the residues, which primes AGO2 for binding a new target. Embryonic death with a strong defect in neural tube closure and apparent cardiac failure. Belongs to the argonaute family. Ago subfamily. Sequence=AAH96465.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA 7-methylguanosine cap binding P-body RNA polymerase II core binding core promoter binding nucleic acid binding RNA binding double-stranded RNA binding single-stranded RNA binding mRNA binding nuclease activity endonuclease activity endoribonuclease activity protein binding nucleus nucleoplasm cytoplasm mitochondrion cytosol polysome mRNA cap binding complex regulation of transcription, DNA-templated regulation of translation multicellular organism development protein C-terminus binding post-embryonic development RNA secondary structure unwinding miRNA metabolic process positive regulation of gene expression RISC complex hydrolase activity endoribonuclease activity, producing 5'-phosphomonoesters cell junction cell differentiation dendrite gene silencing by RNA pre-miRNA processing siRNA loading onto RISC involved in RNA interference production of miRNAs involved in gene silencing by miRNA siRNA binding miRNA binding miRNA mediated inhibition of translation mRNA cleavage involved in gene silencing by miRNA miRNA loading onto RISC involved in gene silencing by miRNA negative regulation of amyloid precursor protein biosynthetic process positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter negative regulation of translational initiation metal ion binding positive regulation of nuclear-transcribed mRNA poly(A) tail shortening extracellular exosome endoribonuclease activity, cleaving siRNA-paired mRNA RISC-loading complex RNA phosphodiester bond hydrolysis, endonucleolytic endoribonuclease activity, cleaving miRNA-paired mRNA mRNA cleavage involved in gene silencing by siRNA mRNA cap binding positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of trophoblast cell migration positive regulation of miRNA mediated inhibition of translation ribonucleoprotein complex uc007wbu.1 uc007wbu.2 uc007wbu.3 uc007wbu.4 
ENSMUST00000044115.9 Zscan2 ENSMUST00000044115.9 zinc finger and SCAN domain containing 2, transcript variant 1 (from RefSeq NM_009553.2) ENSMUST00000044115.1 ENSMUST00000044115.2 ENSMUST00000044115.3 ENSMUST00000044115.4 ENSMUST00000044115.5 ENSMUST00000044115.6 ENSMUST00000044115.7 ENSMUST00000044115.8 NM_009553 Q07230 ZSCA2_MOUSE Zfp-29 Zfp29 uc009ibi.1 uc009ibi.2 uc009ibi.3 uc009ibi.4 May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. Nucleus In the adult, predominantly found in spermatids. Also present in the embryo. Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development spermatogenesis cell differentiation sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding uc009ibi.1 uc009ibi.2 uc009ibi.3 uc009ibi.4 
ENSMUST00000044116.14 Spart ENSMUST00000044116.14 spartin, transcript variant 1 (from RefSeq NM_144895.2) ENSMUST00000044116.1 ENSMUST00000044116.10 ENSMUST00000044116.11 ENSMUST00000044116.12 ENSMUST00000044116.13 ENSMUST00000044116.2 ENSMUST00000044116.3 ENSMUST00000044116.4 ENSMUST00000044116.5 ENSMUST00000044116.6 ENSMUST00000044116.7 ENSMUST00000044116.8 ENSMUST00000044116.9 Kiaa0610 NM_144895 Q6ZQ87 Q8BJD3 Q8BM37 Q8BZ63 Q8R1X6 SPART_MOUSE Spart Spg20 uc008pgb.1 uc008pgb.2 uc008pgb.3 uc008pgb.4 May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. Interacts with ITCH and WWP1. Interacts (via MIT domain) with IST1; leading to the recruitment of SPART to midbodies. Cytoplasm Midbody Note=Transiently associated with endosomes. Colocalized with IST1 to the ends of Flemming bodies during cytokinesis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R1X6-1; Sequence=Displayed; Name=2; IsoId=Q8R1X6-2; Sequence=VSP_010934; Ubiquitinated; ubiquitination does not require ITCH and WWP1. Sequence=BAC39856.1; Type=Erroneous initiation; Evidence=; Sequence=BAC97981.1; Type=Erroneous initiation; Evidence=; protein binding cytoplasm mitochondrial outer membrane lipid particle cytosol plasma membrane abscission midbody negative regulation of BMP signaling pathway ubiquitin protein ligase binding lipid particle organization synapse negative regulation of collateral sprouting in absence of injury neuromuscular process cell division regulation of mitochondrial membrane potential adipose tissue development uc008pgb.1 uc008pgb.2 uc008pgb.3 uc008pgb.4 
ENSMUST00000044123.2 Trhr2 ENSMUST00000044123.2 thyrotropin releasing hormone receptor 2 (from RefSeq NM_133202.3) ENSMUST00000044123.1 NM_133202 Q9ERT2 Q9ERT2_MOUSE TRH-R2 Trhr2 uc009nsk.1 uc009nsk.2 Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity thyrotropin-releasing hormone receptor activity protein binding integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway membrane integral component of membrane neuronal cell body uc009nsk.1 uc009nsk.2 
ENSMUST00000044125.11 Nkx6-1 ENSMUST00000044125.11 NK6 homeobox 1 (from RefSeq NM_144955.2) B2RQP4 ENSMUST00000044125.1 ENSMUST00000044125.10 ENSMUST00000044125.2 ENSMUST00000044125.3 ENSMUST00000044125.4 ENSMUST00000044125.5 ENSMUST00000044125.6 ENSMUST00000044125.7 ENSMUST00000044125.8 ENSMUST00000044125.9 NKX61_MOUSE NM_144955 Nkx6.1 Nkx6a Q99MA9 Q9ERQ7 uc008yim.1 uc008yim.2 uc008yim.3 uc008yim.4 Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Required for the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (PubMed:11076772). Involved in transcriptional regulation of the insulin gene. Together with NKX2-2 and IRX3, restricts the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals. Nucleus Expressed by neuronal progenitor cells in discrete domains of the ventral neural tube (PubMed:10830170). In the pancreas, expressed exclusively in insulin-producing beta cells of the islets of Langerhans (at protein level) (PubMed:11076772). In the developing pancreas, detected as early as 10.5 dpc in the majority of epithelial cells. This broad expression pattern persists through 12.5 dpc. Around 13.5 dpc, with the start of the secondary transition, becomes restricted and by 15.5 dpc, exclusively detected in insulin-expressing beta cells and in some scattered ductal and periductal cells (at protein level). The C-terminal domain contributes to sequence-specific DNA- binding. Embryonic development of mutant mice is normal until 13.5 dpc. At this stage, the normal expansion of pancreatic beta cells does not occur. At 18.5 dpc, the numbers of beta cells is dramatically decreased and the pancreatic insulin content is only 2% of wild-type. No effect on the production of other pancreatic hormones, including glucagon, somatostatin and pancreatic polypeptide (PP) (PubMed:11076772). Simultaneous knockout of NKX6-1 and NKX2-2 results in the complete absence of insulin-expressing cells in the pancreas throughout development, and instead accumulation of incompletely differentiated beta cells, a phenotype not distinguable from the single NKX2-2 knockout (PubMed:11076772). negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding neuron migration type B pancreatic cell differentiation type B pancreatic cell development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter smoothened signaling pathway multicellular organism development cell proliferation regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification central nervous system neuron differentiation neurogenesis cell differentiation regulation of axon extension endocrine pancreas development positive regulation of insulin secretion response to nicotine response to drug sequence-specific DNA binding type B pancreatic cell proliferation positive regulation of neuron differentiation negative regulation of glial cell differentiation positive regulation of glial cell differentiation positive regulation of transcription from RNA polymerase II promoter oligodendrocyte differentiation regulation of insulin secretion cellular response to cytokine stimulus cellular response to peptide hormone stimulus regulation of neuron migration uc008yim.1 uc008yim.2 uc008yim.3 uc008yim.4 
ENSMUST00000044138.8 Chst7 ENSMUST00000044138.8 carbohydrate sulfotransferase 7 (from RefSeq NM_021715.1) CHST7_MOUSE ENSMUST00000044138.1 ENSMUST00000044138.2 ENSMUST00000044138.3 ENSMUST00000044138.4 ENSMUST00000044138.5 ENSMUST00000044138.6 ENSMUST00000044138.7 Gst5 NM_021715 Q99NB0 Q9EP78 uc009sss.1 uc009sss.2 uc009sss.3 uc009sss.4 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc. Reaction=n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+); Xref=Rhea:RHEA:11108, Rhea:RHEA-COMP:9827, Rhea:RHEA-COMP:9828, ChEBI:CHEBI:15378, ChEBI:CHEBI:57652, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:62065; EC=2.8.2.17; Golgi apparatus membrane ; Single- pass type II membrane protein Widely expressed. Highly expressed in kidney. Expressed at lower level in heart, lung and liver. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. Golgi membrane N-acetylglucosamine 6-O-sulfotransferase activity Golgi apparatus trans-Golgi network carbohydrate metabolic process N-acetylglucosamine metabolic process sulfur compound metabolic process sulfotransferase activity chondroitin 6-sulfotransferase activity membrane integral component of membrane transferase activity chondroitin sulfate biosynthetic process uc009sss.1 uc009sss.2 uc009sss.3 uc009sss.4 
ENSMUST00000044143.6 Rln1 ENSMUST00000044143.6 relaxin 1 (from RefSeq NM_011272.2) A2RTV8 A2RTV8_MOUSE ENSMUST00000044143.1 ENSMUST00000044143.2 ENSMUST00000044143.3 ENSMUST00000044143.4 ENSMUST00000044143.5 NM_011272 Rln1 uc008hde.1 uc008hde.2 uc008hde.3 uc008hde.4 Heterodimer of a B chain and an A chain linked by two disulfide bonds. Secreted Belongs to the insulin family. hormone activity extracellular region signal transduction uc008hde.1 uc008hde.2 uc008hde.3 uc008hde.4 
ENSMUST00000044148.3 Alg2 ENSMUST00000044148.3 ALG2 alpha-1,3/1,6-mannosyltransferase, transcript variant 1 (from RefSeq NM_019998.3) ALG2_MOUSE ENSMUST00000044148.1 ENSMUST00000044148.2 MNCb-5081 NM_019998 Q7TN30 Q9CWI6 Q9DBE8 Q9JJA8 uc008suq.1 uc008suq.2 uc008suq.3 uc008suq.4 Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Reaction=beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc- diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D- Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+); Xref=Rhea:RHEA:29515, Rhea:RHEA-COMP:11044, Rhea:RHEA- COMP:12624, ChEBI:CHEBI:15378, ChEBI:CHEBI:57527, ChEBI:CHEBI:58189, ChEBI:CHEBI:58472, ChEBI:CHEBI:132510; EC=2.4.1.132; Evidence=; Reaction=alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man- (1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- alpha-D-GlcNAc-diphosphodolichol + GDP + H(+); Xref=Rhea:RHEA:29519, Rhea:RHEA-COMP:12624, Rhea:RHEA-COMP:12626, ChEBI:CHEBI:15378, ChEBI:CHEBI:57527, ChEBI:CHEBI:58189, ChEBI:CHEBI:132510, ChEBI:CHEBI:132511; EC=2.4.1.257; Evidence=; Protein modification; protein glycosylation. Membrane ; Single-pass membrane protein Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. alpha-1,3-mannosyltransferase activity GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity nucleus cytoplasm endoplasmic reticulum cytosol protein glycosylation dolichol-linked oligosaccharide biosynthetic process oligosaccharide-lipid intermediate biosynthetic process actin cytoskeleton membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein glycosylation in endoplasmic reticulum protein heterodimerization activity protein N-terminus binding calcium-dependent protein binding perinuclear region of cytoplasm response to calcium ion mannosylation GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity uc008suq.1 uc008suq.2 uc008suq.3 uc008suq.4 
ENSMUST00000044152.13 Hid1 ENSMUST00000044152.13 HID1 domain containing, transcript variant 2 (from RefSeq NM_001346774.1) A2A6S8 ENSMUST00000044152.1 ENSMUST00000044152.10 ENSMUST00000044152.11 ENSMUST00000044152.12 ENSMUST00000044152.2 ENSMUST00000044152.3 ENSMUST00000044152.4 ENSMUST00000044152.5 ENSMUST00000044152.6 ENSMUST00000044152.7 ENSMUST00000044152.8 ENSMUST00000044152.9 HID1_MOUSE NM_001346774 Q8C8V6 Q8R1F6 uc007mhh.1 uc007mhh.2 uc007mhh.3 Cytoplasm Golgi apparatus membrane ; Lipid-anchor Note=Shuttles between the cytosol and the Golgi apparatus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R1F6-1; Sequence=Displayed; Name=2; IsoId=Q8R1F6-2; Sequence=VSP_014474; Belongs to the hid-1 family. Golgi trans cisterna Golgi membrane molecular_function cytoplasm Golgi apparatus Golgi medial cisterna cytosol cytoplasmic microtubule membrane extrinsic component of Golgi membrane uc007mhh.1 uc007mhh.2 uc007mhh.3 
ENSMUST00000044155.15 Ubash3b ENSMUST00000044155.15 ubiquitin associated and SH3 domain containing, B, transcript variant 1 (from RefSeq NM_176860.6) ENSMUST00000044155.1 ENSMUST00000044155.10 ENSMUST00000044155.11 ENSMUST00000044155.12 ENSMUST00000044155.13 ENSMUST00000044155.14 ENSMUST00000044155.2 ENSMUST00000044155.3 ENSMUST00000044155.4 ENSMUST00000044155.5 ENSMUST00000044155.6 ENSMUST00000044155.7 ENSMUST00000044155.8 ENSMUST00000044155.9 NM_176860 Q3U8Z2 Q8BGG7 Q8BMW9 Sts1 UBS3B_MOUSE uc009pag.1 uc009pag.2 uc009pag.3 Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Homodimer (PubMed:20516590, PubMed:17679096). Interacts with JAK2 (in vitro) (PubMed:12370296). Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins (By similarity). Interacts with ZAP70 (ubiquitinated form) (PubMed:26903241). Q8BGG7; P43403: ZAP70; Xeno; NbExp=10; IntAct=EBI-8846415, EBI-1211276; Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGG7-1; Sequence=Displayed; Name=2; IsoId=Q8BGG7-2; Sequence=VSP_019716; Detected in splenic T-cells and B-cells, total spleen, skeletal muscle, heart, lung, kidney, thymus, brain and liver (at protein level). Highly expressed in brain. Detected in heart, spleen, lung, liver, kidney and testis. Mice display strikingly elevated levels of tyrosine phosphorylated, ubiquitinated proteins following TCR stimulation. They are prothrombotic and have shorter bleeding times, which is attributed to insufficient SYK dephosphorylation in platelets. phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding cellular_component nucleus cytoplasm negative regulation of protein kinase activity negative regulation of signal transduction hydrolase activity platelet activation ubiquitin protein ligase binding peptidyl-tyrosine dephosphorylation collagen-activated tyrosine kinase receptor signaling pathway collagen-activated signaling pathway identical protein binding regulation of protein binding regulation of osteoclast differentiation negative regulation of osteoclast differentiation negative regulation of bone resorption phosphoprotein binding regulation of release of sequestered calcium ion into cytosol platelet aggregation negative regulation of platelet aggregation uc009pag.1 uc009pag.2 uc009pag.3 
ENSMUST00000044158.13 Nop53 ENSMUST00000044158.13 NOP53 ribosome biogenesis factor (from RefSeq NM_133831.3) ENSMUST00000044158.1 ENSMUST00000044158.10 ENSMUST00000044158.11 ENSMUST00000044158.12 ENSMUST00000044158.2 ENSMUST00000044158.3 ENSMUST00000044158.4 ENSMUST00000044158.5 ENSMUST00000044158.6 ENSMUST00000044158.7 ENSMUST00000044158.8 ENSMUST00000044158.9 Gltscr2 NM_133831 NOP53_MOUSE Nop53 Pict1 Q8BK35 Q8VD18 uc009fgr.1 uc009fgr.2 uc009fgr.3 uc009fgr.4 uc009fgr.5 Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription (By similarity). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:21804542). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin- mediated proteasomal degradation. Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway. May also inhibit cell proliferation and increase apoptosis through its interaction with NF2. May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation. Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex. May also regulate cellular aerobic respiration. In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (By similarity). Homooligomer. Interacts with PTEN; regulates PTEN phosphorylation and increases its stability (By similarity). Interacts with RPL11; retains RPL11 into the nucleolus (PubMed:21804542). Interacts with CDKN2A/isoform tumor suppressor ARF; the interaction is direct and promotes ARF nucleoplasmic relocalization and ubiquitin- mediated proteasomal degradation. Interacts with NPM1; the interaction is direct and competitive with MYC. Interacts with NF2 (via FERM domain); the interaction is direct. Interacts with p53/TP53 (via the oligomerization region); the interaction is direct and may prevent the MDM2-mediated proteasomal degradation of p53/TP53. Interacts with RIGI; may regulate RIGI through USP15-mediated 'Lys-63'-linked deubiquitination. Interacts with UBTF (By similarity). Nucleus, nucleolus Nucleus, nucleoplasm Note=In the nucleolus may be more specifically localized to the fibrillar center. Mainly nucleolar it relocalizes to the nucleoplasm under specific conditions including ribosomal stress enabling it to interact and regulate nucleoplasmic proteins like p53/TP53. Also detected in the cytosol. Ubiquitin-mediated proteasomal degradation is regulated by c-JUN. It is associated with relocalization to the nucleoplasm and decreased homooligomerization. Phosphorylated upon DNA damage probably by ATM and DNA-PK; may regulate NOP53 degradation. Knockout embryos are not able to form viable blastocysts. Transgenic mice lacking the expression of Nop53 in the thymus display a dramatic reduction of the number of thymic cells and of the size of the thymus. Belongs to the NOP53 family. ribosomal large subunit assembly negative regulation of transcription from RNA polymerase II promoter fibrillar center regulation of protein phosphorylation p53 binding protein binding nucleus nucleoplasm nucleolus cytosol DNA repair rRNA processing cellular response to DNA damage stimulus mitotic G2 DNA damage checkpoint 5S rRNA binding negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of protein complex assembly negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process rDNA heterochromatin regulation of RIG-I signaling pathway ribosome biogenesis identical protein binding regulation of apoptotic process intracellular membrane-bounded organelle protein stabilization regulation of cell cycle negative regulation of protein kinase B signaling cellular response to hypoxia regulation of signal transduction by p53 class mediator negative regulation of signal transduction by p53 class mediator negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter protein localization to nucleolus positive regulation of protein K63-linked deubiquitination regulation of aerobic respiration protein localization to nucleoplasm uc009fgr.1 uc009fgr.2 uc009fgr.3 uc009fgr.4 uc009fgr.5 
ENSMUST00000044159.7 Serpina6 ENSMUST00000044159.7 serine (or cysteine) peptidase inhibitor, clade A, member 6 (from RefSeq NM_007618.3) CBG_MOUSE Cbg ENSMUST00000044159.1 ENSMUST00000044159.2 ENSMUST00000044159.3 ENSMUST00000044159.4 ENSMUST00000044159.5 ENSMUST00000044159.6 NM_007618 Q06770 uc007owa.1 uc007owa.2 uc007owa.3 uc007owa.4 uc007owa.5 This gene encodes a protein that belongs to the serpin (serine protease inhibitor) family. The encoded protein is an alpha-globulin with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013632.1, AK145842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. Secreted. Expressed by the liver; secreted in plasma. Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids (By similarity). Belongs to the serpin family. serine-type endopeptidase inhibitor activity steroid binding extracellular region extracellular space glucocorticoid metabolic process lipid binding negative regulation of endopeptidase activity uc007owa.1 uc007owa.2 uc007owa.3 uc007owa.4 uc007owa.5 
ENSMUST00000044165.14 Itga9 ENSMUST00000044165.14 integrin alpha 9, transcript variant 1 (from RefSeq NM_133721.2) B8JK39 B9EKC4 ENSMUST00000044165.1 ENSMUST00000044165.10 ENSMUST00000044165.11 ENSMUST00000044165.12 ENSMUST00000044165.13 ENSMUST00000044165.2 ENSMUST00000044165.3 ENSMUST00000044165.4 ENSMUST00000044165.5 ENSMUST00000044165.6 ENSMUST00000044165.7 ENSMUST00000044165.8 ENSMUST00000044165.9 ITA9_MOUSE Itga9 NM_133721 uc009rzw.1 uc009rzw.2 uc009rzw.3 uc009rzw.4 Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D- G-I-E-L in cytotactin. ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (PubMed:22654117). Integrin ITGA9:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction (PubMed:35802072). Heterodimer of an alpha and a beta subunit. Alpha-9 (ITGA9) associates with beta-1 (ITGB1) (Probable). Integrin ITGA9:ITGB1 interacts with FBLN5 (via N-terminus) (PubMed:11805835). Integrin ITGA9:ITGB1 interacts with SPP1/OPN (via N-terminus) (PubMed:22654117). Integrin ITGA9:ITGB1 interacts with TNC/TNFN3 (via the 3rd Fibronectin type-III domain) (PubMed:22654117). Integrin ITGA9:ITGB1 interacts with SVEP1/polydom (via Sushi domain 21); thereby inhibits Ca(2+) intracellular signaling and as a result represses vasocontraction (PubMed:22654117, PubMed:28179430). Membrane ; Single-pass type I membrane protein Expressed in the media layer of the arterial wall (at protein level) (PubMed:35802072). Expressed in the airway epithelium, skeletal muscle, basal keratincytes, the basal epithelium of the cornea, hepatocytes, giant cells in the spleen and smooth muscle of the stomach, duodenum and veins (at protein level) (PubMed:8245132). Expressed at the submucosal mesenchyme and smooth muscle layer in the stomach and intestine at 16.5 dpc (at protein level) (PubMed:22654117). Expressed in the sinusoids in the liver, and Bowmans capsules and inter-renal tubule mesenchyme at 16.5 dpc (at protein level) (PubMed:22654117). Abundantly expressed in the smooth muscle layer of the lung at 16.5 dpc (at protein level) (PubMed:22654117). Abundantly expressed in the smooth muscle layer surrounding the trachea at 16.5 dpc (at protein level) (PubMed:22654117). Expressed in the mesentery lymphatic vessel and nerve at 18.5 dpc (at protein level) (PubMed:28179432). Belongs to the integrin alpha chain family. collagen binding cell adhesion integrin-mediated signaling pathway integrin complex basal plasma membrane membrane integral component of membrane neutrophil chemotaxis integrin alpha9-beta1 complex wound healing laminin binding metal ion binding uc009rzw.1 uc009rzw.2 uc009rzw.3 uc009rzw.4 
ENSMUST00000044166.9 Cdc40 ENSMUST00000044166.9 cell division cycle 40 (from RefSeq NM_027879.2) B2RY33 ENSMUST00000044166.1 ENSMUST00000044166.2 ENSMUST00000044166.3 ENSMUST00000044166.4 ENSMUST00000044166.5 ENSMUST00000044166.6 ENSMUST00000044166.7 ENSMUST00000044166.8 NM_027879 PRP17_MOUSE Prp17 Prpf17 Q9DC48 uc007exe.1 uc007exe.2 uc007exe.3 uc007exe.4 uc007exe.5 uc007exe.6 Required for pre-mRNA splicing as component of the activated spliceosome (By similarity). Plays an important role in embryonic brain development; this function does not require proline peptide bond isomerization (PubMed:33220177). Component of the catalytic spliceosome C complexes. Component of the postcatalytic spliceosome P complex (By similarity). Interacts with PPIL1; this interaction leads to CDC40 isomerization (By similarity). Nucleus Nucleus speckle Undergoes isomerization of the peptide bond between Gly-94 and Pro-95. The reaction is catalyzed by PPIL1. mRNA splicing, via spliceosome nucleus spliceosomal complex mRNA processing RNA splicing nuclear speck U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome uc007exe.1 uc007exe.2 uc007exe.3 uc007exe.4 uc007exe.5 uc007exe.6 
ENSMUST00000044179.8 Tex13b ENSMUST00000044179.8 testis expressed 13B (from RefSeq NM_031381.2) ENSMUST00000044179.1 ENSMUST00000044179.2 ENSMUST00000044179.3 ENSMUST00000044179.4 ENSMUST00000044179.5 ENSMUST00000044179.6 ENSMUST00000044179.7 NM_031381 Q99MW5 Q99MW5_MOUSE Tex13 Tex13b uc009ulg.1 uc009ulg.2 Belongs to the TEX13 family. molecular_function cellular_component biological_process uc009ulg.1 uc009ulg.2 
ENSMUST00000044180.5 Npbwr1 ENSMUST00000044180.5 neuropeptides B/W receptor 1 (from RefSeq NM_010342.1) ENSMUST00000044180.1 ENSMUST00000044180.2 ENSMUST00000044180.3 ENSMUST00000044180.4 Gpr7 NM_010342 NPBW1_MOUSE P49681 uc011whw.1 uc011whw.2 Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway neuropeptide receptor activity membrane integral component of membrane regulation of metabolic process peptide binding neuropeptide binding uc011whw.1 uc011whw.2 
ENSMUST00000044188.5 Dipk2b ENSMUST00000044188.5 divergent protein kinase domain 2B, transcript variant 1 (from RefSeq NM_175228.4) DIK2B_MOUSE ENSMUST00000044188.1 ENSMUST00000044188.2 ENSMUST00000044188.3 ENSMUST00000044188.4 NM_175228 Q8C3I9 uc009ssp.1 uc009ssp.2 uc009ssp.3 uc009ssp.4 Secreted Belongs to the DIPK family. molecular_function cellular_component extracellular region uc009ssp.1 uc009ssp.2 uc009ssp.3 uc009ssp.4 
ENSMUST00000044189.16 Senp1 ENSMUST00000044189.16 SUMO1/sentrin specific peptidase 1, transcript variant 2 (from RefSeq NM_144851.5) ENSMUST00000044189.1 ENSMUST00000044189.10 ENSMUST00000044189.11 ENSMUST00000044189.12 ENSMUST00000044189.13 ENSMUST00000044189.14 ENSMUST00000044189.15 ENSMUST00000044189.2 ENSMUST00000044189.3 ENSMUST00000044189.4 ENSMUST00000044189.5 ENSMUST00000044189.6 ENSMUST00000044189.7 ENSMUST00000044189.8 ENSMUST00000044189.9 NM_144851 P59110 Q8BTV5 Q8BZF1 SENP1_MOUSE Supr2 uc007xls.1 uc007xls.2 uc007xls.3 uc007xls.4 uc007xls.5 Protease that catalyzes two essential functions in the SUMO pathway (PubMed:15923632, PubMed:29499132). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (By similarity). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (By similarity). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (By similarity). Deconjugates SUMO2 from MTA1 (By similarity). Deconjugates SUMO1 from METTL3 (By similarity). Desumoylates CCAR2 which decreases its interaction with SIRT1 (By similarity). Deconjugates SUMO1 from GPS2 (PubMed:29499132). Interacts with MTA1. Interacts with CCAR2 (via N-terminus). Nucleus Cytoplasm Note=Shuttles between cytoplasm and nucleus. Expression starts at 9.5 dpc. Death between 13.5 dpc and 14.5 dpc due to abnormalities in fetal vessels. Belongs to the peptidase C48 family. protein binding nucleus cytoplasm focal adhesion proteolysis activation of cysteine-type endopeptidase activity involved in apoptotic process multicellular organism development peptidase activity cysteine-type peptidase activity regulation of definitive erythrocyte differentiation hydrolase activity protein desumoylation nuclear membrane negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of transcription from RNA polymerase II promoter SUMO-specific isopeptidase activity apoptotic signaling pathway uc007xls.1 uc007xls.2 uc007xls.3 uc007xls.4 uc007xls.5 
ENSMUST00000044190.12 Hhat ENSMUST00000044190.12 hedgehog acyltransferase (from RefSeq NM_144881.5) B1ANS0 ENSMUST00000044190.1 ENSMUST00000044190.10 ENSMUST00000044190.11 ENSMUST00000044190.2 ENSMUST00000044190.3 ENSMUST00000044190.4 ENSMUST00000044190.5 ENSMUST00000044190.6 ENSMUST00000044190.7 ENSMUST00000044190.8 ENSMUST00000044190.9 HHAT_MOUSE NM_144881 Q3TA33 Q8BMT9 Q922G3 Skn uc007edp.1 uc007edp.2 uc007edp.3 uc007edp.4 Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling during limb development (PubMed:15075292). It also catalyzes N-terminal palmitoylation of DHH (By similarity). Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where SHH palmitoylation occurs (By similarity). Plays a role in proper testis cord formation and the differentiation of Leydig cells (PubMed:24784881). Reaction=hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59528, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:15376, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:65250, ChEBI:CHEBI:143147; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59529; Evidence=; Reaction=hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester = CoA + H(+) + N-terminal N-hexadecanoyl-L- cysteinyl-[protein]-C-terminal glycyl cholesterol ester; Xref=Rhea:RHEA:59580, Rhea:RHEA-COMP:15388, Rhea:RHEA-COMP:15389, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:65250, ChEBI:CHEBI:143135, ChEBI:CHEBI:143147; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59581; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Note=Co-localizes with SHH in the ER and Golgi membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BMT9-1; Sequence=Displayed; Name=2; IsoId=Q8BMT9-2; Sequence=VSP_016690, VSP_016691; Broadly expressed from 7 dpc. At 10.5 dpc, strongly expressed in anterior ectoderm, pharyngeal arches, and distal part of the limb. Conditional knockout embryos are characterized by a smaller size and holoprosencephaly at 10.5 dpc, shortening of limbs at 13.5 dpc, and severe short-limb dwarfism at birth. They die soon after birth. Testicular development is significantly impaired in XY embryos by 12.5 dpc. There is a massive reduction in testis size, a reduction in the number of testis cords which are irregular in shape and diameter, and an almost complete absence of Leydig cells (PubMed:24784881). Belongs to the membrane-bound acyltransferase family. HHAT subfamily. nucleotide binding GTP binding endoplasmic reticulum endoplasmic reticulum membrane smoothened signaling pathway multicellular organism development membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups protein palmitoylation uc007edp.1 uc007edp.2 uc007edp.3 uc007edp.4 
ENSMUST00000044195.6 Tmc7 ENSMUST00000044195.6 transmembrane channel-like gene family 7 (from RefSeq NM_172476.5) ENSMUST00000044195.1 ENSMUST00000044195.2 ENSMUST00000044195.3 ENSMUST00000044195.4 ENSMUST00000044195.5 NM_172476 Q7TN59 Q7TQ66 Q8C428 Q8C4C3 TMC7_MOUSE uc009jka.1 uc009jka.2 uc009jka.3 Probable ion channel. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C428-1; Sequence=Displayed; Name=2; IsoId=Q8C428-2; Sequence=VSP_025348; Ubiquitously expressed. Belongs to the TMC family. ion channel activity cellular_component integral component of plasma membrane ion transport mechanically-gated ion channel activity membrane integral component of membrane ion transmembrane transport transmembrane transport uc009jka.1 uc009jka.2 uc009jka.3 
ENSMUST00000044200.11 Nop2 ENSMUST00000044200.11 NOP2 nucleolar protein (from RefSeq NM_138747.2) E9QN31 E9QN31_MOUSE ENSMUST00000044200.1 ENSMUST00000044200.10 ENSMUST00000044200.2 ENSMUST00000044200.3 ENSMUST00000044200.4 ENSMUST00000044200.5 ENSMUST00000044200.6 ENSMUST00000044200.7 ENSMUST00000044200.8 ENSMUST00000044200.9 NM_138747 Nop2 uc009dtn.1 uc009dtn.2 uc009dtn.3 uc009dtn.4 Nucleus, nucleolus Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. RNA binding rRNA processing methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity transferase activity methylation uc009dtn.1 uc009dtn.2 uc009dtn.3 uc009dtn.4 
ENSMUST00000044207.5 Sart1 ENSMUST00000044207.5 squamous cell carcinoma antigen recognized by T cells 1 (from RefSeq NM_016882.3) ENSMUST00000044207.1 ENSMUST00000044207.2 ENSMUST00000044207.3 ENSMUST00000044207.4 Haf NM_016882 Q8K155 Q9R1I9 Q9R270 Q9Z315 SNUT1_MOUSE uc008gcu.1 uc008gcu.2 Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Identified in the spliceosome C complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Interacts with UBL5. Nucleus Note=Found in the nucleus of mitogen-activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells. Ubiquitously expressed. Shows a high expression in fetal liver and a low expression in adult liver. Expressed at maximal level at 12 dpc. Declines progressively until birth. Sumoylated with SUMO2. Belongs to the SNU66/SART1 family. mRNA splicing, via spliceosome maturation of 5S rRNA nucleus nucleoplasm spliceosomal complex Golgi apparatus mRNA processing RNA splicing Cajal body nuclear speck mRNA cis splicing, via spliceosome positive regulation of cytotoxic T cell differentiation U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome catalytic step 2 spliceosome uc008gcu.1 uc008gcu.2 
ENSMUST00000044210.5 Myf6 ENSMUST00000044210.5 myogenic factor 6 (from RefSeq NM_008657.3) ENSMUST00000044210.1 ENSMUST00000044210.2 ENSMUST00000044210.3 ENSMUST00000044210.4 Myf6 NM_008657 Q0VEJ7 Q0VEJ7_MOUSE uc007gza.1 uc007gza.2 uc007gza.3 Nucleus DNA binding nucleus regulation of transcription, DNA-templated muscle organ development skeletal muscle tissue regeneration protein dimerization activity uc007gza.1 uc007gza.2 uc007gza.3 
ENSMUST00000044217.16 Syne2 ENSMUST00000044217.16 spectrin repeat containing, nuclear envelope 2 (from RefSeq NM_001005510.2) ENSMUST00000044217.1 ENSMUST00000044217.10 ENSMUST00000044217.11 ENSMUST00000044217.12 ENSMUST00000044217.13 ENSMUST00000044217.14 ENSMUST00000044217.15 ENSMUST00000044217.2 ENSMUST00000044217.3 ENSMUST00000044217.4 ENSMUST00000044217.5 ENSMUST00000044217.6 ENSMUST00000044217.7 ENSMUST00000044217.8 ENSMUST00000044217.9 NM_001005510 Q640M5 Q6ZWQ0 SYNE2_MOUSE Syne2 uc007nxp.1 uc007nxp.2 uc007nxp.3 Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 seem to act redundantly in cerebellum, midbrain, brain stem, and other brain regions except cerebral cortex and hippocampus. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Core component of LINC complexes which are composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain- containing proteins seem to bind each other promiscuously; however, some LINC complex constituents are tissue- or cell type-specific. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain- containing protein. The SUN2:SYNE2/KASH2 complex is a heterohexamer; the homotrimeric cloverleave-like conformation of the SUN domain is a prerequisite for LINC complex formation in which three separate SYNE2/KASH2 peptides bind at the interface of adjacent SUN domains. Interacts with EMD, LMNA, MKS3 and F-actin via its N-terminal domain. Interacts with DCTN1 and DYNC1I1/2; suggesting the association with the dynein-dynactin motor complex. Associates with kinesin motor complexes. Interacts with TMEM67. Interacts (via KASH domain) with TMEM258 (By similarity). Interacts with BROX; this interaction promotes SYN2 ubiquitination and facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site (By similarity). Q6ZWQ0-1; Q8BJS4-3: Sun2; NbExp=2; IntAct=EBI-16108623, EBI-16189250; Q6ZWQ0-1; Q9Y613: FHOD1; Xeno; NbExp=2; IntAct=EBI-16108623, EBI-348433; Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Sarcoplasmic reticulum membrane ; Single-pass type IV membrane protein Cell membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton. Mitochondrion Nucleus, nucleoplasm Note=Different isoform patterns are found in the different compartments of the cell. The isoforms having the C-terminal transmembrane span can be found in several organellar membranes like the nuclear envelope, the sarcoplasmic reticulum of myoblasts, or the lamellipodia and focal adhesions at the cell membrane. The largest part of the outer nuclear membrane-associated protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. Remains associated with the nuclear envelope during its breakdown in mitotic cells. Shorter soluble isoforms can be found in the cytoplasm and within the nucleus (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Nesprin-2 Giant, Nesp2G, NUANCE; IsoId=Q6ZWQ0-1; Sequence=Displayed; Name=2; IsoId=Q6ZWQ0-2; Sequence=VSP_038800, VSP_038801; Name=3; IsoId=Q6ZWQ0-3; Sequence=VSP_038799, VSP_038802; C-terminal isoforms are highly expressed in the brain, hert and skeletal muscle. Isoform 1 (Nesprin-2 Giant) is most prevalent in the brain, skin, kidney and skeletal muscle. The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains. The disulfid bond with SUN2 is required for stability of the SUN2:SYNE2/KASH2 LINC complex under tensile forces though not required for the interaction. Belongs to the nesprin family. actin binding protein binding nucleus nuclear envelope nuclear outer membrane nucleoplasm cytoplasm mitochondrion cytoskeleton plasma membrane focal adhesion nuclear envelope organization nuclear migration establishment or maintenance of cell polarity fibroblast migration membrane integral component of membrane aggresome sarcoplasmic reticulum nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration Z disc positive regulation of cell migration nuclear migration along microfilament lamellipodium membrane filopodium membrane nuclear membrane nuclear lumen sarcoplasmic reticulum membrane protein localization to nucleus LINC complex intermediate filament cytoskeleton actin filament binding centrosome localization cytoskeletal anchoring at nuclear membrane regulation of cilium assembly myofibril uc007nxp.1 uc007nxp.2 uc007nxp.3 
ENSMUST00000044220.11 Cmc1 ENSMUST00000044220.11 C-X9-C motif containing 1 (from RefSeq NM_026442.3) COXM1_MOUSE ENSMUST00000044220.1 ENSMUST00000044220.10 ENSMUST00000044220.2 ENSMUST00000044220.3 ENSMUST00000044220.4 ENSMUST00000044220.5 ENSMUST00000044220.6 ENSMUST00000044220.7 ENSMUST00000044220.8 ENSMUST00000044220.9 NM_026442 Q6PH95 Q80ZR0 Q9CPZ8 uc009rzl.1 uc009rzl.2 uc009rzl.3 uc009rzl.4 uc009rzl.5 Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14. Mitochondrion Note=Colocalizes with MT-CO1. Belongs to the CMC family. Sequence=AAH48547.1; Type=Erroneous initiation; Evidence=; molecular_function mitochondrion biological_process metal ion binding uc009rzl.1 uc009rzl.2 uc009rzl.3 uc009rzl.4 uc009rzl.5 
ENSMUST00000044224.5 Oas1d ENSMUST00000044224.5 2'-5' oligoadenylate synthetase 1D (from RefSeq NM_133893.3) ENSMUST00000044224.1 ENSMUST00000044224.2 ENSMUST00000044224.3 ENSMUST00000044224.4 NM_133893 OAS1D_MOUSE Oas1d Oasl8 Q3UWZ6 Q7TPY2 Q8VI95 uc008zik.1 uc008zik.2 uc008zik.3 uc008zik.4 uc008zik.5 Does not have 2'-5'-olygoadenylate synthetase activity, but can bind double-stranded RNA (PubMed:15899864, PubMed:12396720). May play a role in the control of female fertility, possibly by binding to and inhibiting OAS1A (PubMed:15899864). Interacts with OAS1A, the interaction inhibits OAS1A catalytic activity. Cytoplasm Expressed specifically in oocytes (at protein level) (PubMed:15899864). Expressed at highest level in ovary with lesser amounts in intestine, brain, thymus lung, kidney, liver and uterus (PubMed:17567914, PubMed:27663720). Detected in fully grown, germinal vesicle (GV)- intact oocytes and in oocytes at the metaphase II stage, with levels decreasing thereafter (at protein level) (PubMed:15899864). Detected 1 week after birth in developing ovary (PubMed:27663720). Detected at 17.5 dpc, with levels increasing thereafter (PubMed:17567914). Unlike other OAS1 proteins, not induced by polyinosinic:polycytidylic acid (poly I:C). Newborn mice are viable. Female mice display reduced fertility due to deficiencies in ovarian follicle development, reduced efficiency of ovulation, and the arrest of fertilized eggs at one-cell stage. Belongs to the 2-5A synthase family. ovarian follicle development ovulation from ovarian follicle RNA binding double-stranded RNA binding enzyme inhibitor activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol immune response transferase activity negative regulation of catalytic activity negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity 2'-5'-oligoadenylate synthetase activity uc008zik.1 uc008zik.2 uc008zik.3 uc008zik.4 uc008zik.5 
ENSMUST00000044231.12 Serpina10 ENSMUST00000044231.12 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10, transcript variant 1 (from RefSeq NM_144834.5) ENSMUST00000044231.1 ENSMUST00000044231.10 ENSMUST00000044231.11 ENSMUST00000044231.2 ENSMUST00000044231.3 ENSMUST00000044231.4 ENSMUST00000044231.5 ENSMUST00000044231.6 ENSMUST00000044231.7 ENSMUST00000044231.8 ENSMUST00000044231.9 NM_144834 Q8R121 Q8VCV8 ZPI_MOUSE Zpi uc007ovz.1 uc007ovz.2 uc007ovz.3 uc007ovz.4 The protein encoded by this gene is a member of the large serpin family of proteins, and is also known as serpin PZ-dependent protease inhibitor (ZPI or PZI). This protein is thought to play an important role in the regulation of coagulation. It directly inhibits factor XIa, and also inhibits factor Xa in the presence of calcium, phospholipids, and protein Z (PZ). Deficiencies in this gene lead to an increase in thrombosis. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Aug 2014]. Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity). Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R121-1; Sequence=Displayed; Name=2; IsoId=Q8R121-2; Sequence=VSP_014439; Detectable in liver, but not in heart, brain, spleen, lung, kidney, skeletal muscle or testes. Phosphorylated by FAM20C in the extracellular medium. Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa. [Isoform 2]: May be due to a competing acceptor splice site. Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular region extracellular space blood coagulation hemostasis heparin binding negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc007ovz.1 uc007ovz.2 uc007ovz.3 uc007ovz.4 
ENSMUST00000044250.4 Alkbh5 ENSMUST00000044250.4 alkB homolog 5, RNA demethylase (from RefSeq NM_172943.4) ALKB5_MOUSE Abh5 Alkbh5 ENSMUST00000044250.1 ENSMUST00000044250.2 ENSMUST00000044250.3 NM_172943 Ofoxd Q3TSG4 Q80US0 Q8BKB9 Q8BKC1 uc007jgd.1 uc007jgd.2 uc007jgd.3 uc007jgd.4 Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:29279410). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (PubMed:23177736, PubMed:29279410). Reaction=2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:49520, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=1.14.11.53; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Monomer. Nucleus speckle Widely expressed, with highest expression in testis (PubMed:23177736). In testis, present in almost all testicular cell types except elongating and elongated spermatids (at protein level) (PubMed:29279410). Among spermatogenic cells, present at high level in spermatocytes; medium levels in spermatogonia and lower levels in round spermatids (at protein level) (PubMed:29279410). Mice are viable, anatomically normal and reach adulthood but display impaired fertility resulting from apoptosis that affects meiotic metaphase-stage spermatocytes (PubMed:23177736, PubMed:29279410). Testes are significantly smaller and histological analysis of testis sections reveal aberrant tubular architecture and size (PubMed:23177736, PubMed:29279410). The number of spermatozoa released from cauda epididymes is dramatically reduced, and the spermatozoa are morphologically abnormal with greatly compromised motility (PubMed:23177736). Male mice display increased m6A in mRNAs in spermatocytes, leading to aberrant splicing and production of shorter transcripts that are rapidly degraded (PubMed:29279410). Belongs to the alkB family. response to hypoxia nucleus nucleoplasm Golgi apparatus cytosol mRNA processing mRNA export from nucleus spermatogenesis oxidoreductase activity nuclear speck oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors cell differentiation oxidative RNA demethylase activity oxidative single-stranded RNA demethylation regulation of mRNA stability metal ion binding dioxygenase activity oxidation-reduction process RNA N6-methyladenosine dioxygenase activity lysophospholipase activity uc007jgd.1 uc007jgd.2 uc007jgd.3 uc007jgd.4 
ENSMUST00000044252.7 Nubp2 ENSMUST00000044252.7 nucleotide binding protein 2, transcript variant 1 (from RefSeq NM_011956.3) ENSMUST00000044252.1 ENSMUST00000044252.2 ENSMUST00000044252.3 ENSMUST00000044252.4 ENSMUST00000044252.5 ENSMUST00000044252.6 NM_011956 NUBP2_MOUSE Q9R061 uc008ayo.1 uc008ayo.2 uc008ayo.3 uc008ayo.4 Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure (PubMed:23807208). Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer. Heterotetramer of 2 NUBP1 and 2 NUBP2 chains (By similarity). Interacts with KIFC1 (PubMed:16638812). Interacts with NUBP1 (PubMed:16638812, PubMed:23807208). Nucleus toplasm, cytoskeleton, microtubule organizing center, centrosome toplasm Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, microtubule organizing center Note=Enriched at the centrosomes during mitosis (By similarity). Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis (PubMed:23807208). Localized at centrioles and in the nucleus at interphase (PubMed:23807208). Colocalizes with nubp-1 at prometaphase (PubMed:23807208). Widely expressed. Expressed at 7, 11, 15 and 17 dpc. Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. nucleotide binding protein binding ATP binding nucleus cytoplasm centriole microtubule organizing center cytosol cytoskeleton cilium iron-sulfur cluster assembly cell projection organization spindle pole centrosome cell projection metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding uc008ayo.1 uc008ayo.2 uc008ayo.3 uc008ayo.4 
ENSMUST00000044271.15 Nploc4 ENSMUST00000044271.15 NPL4 homolog, ubiquitin recognition factor, transcript variant A (from RefSeq NM_001195023.1) B1ATY4 B1ATY5 ENSMUST00000044271.1 ENSMUST00000044271.10 ENSMUST00000044271.11 ENSMUST00000044271.12 ENSMUST00000044271.13 ENSMUST00000044271.14 ENSMUST00000044271.2 ENSMUST00000044271.3 ENSMUST00000044271.4 ENSMUST00000044271.5 ENSMUST00000044271.6 ENSMUST00000044271.7 ENSMUST00000044271.8 ENSMUST00000044271.9 Kiaa1499 NM_001195023 NPL4_MOUSE Npl4 P60670 uc007msq.1 uc007msq.2 uc007msq.3 uc007msq.4 The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (By similarity). Protein degradation; proteasomal ubiquitin-dependent pathway. Heterodimer with UFD1. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion (By similarity). Interacts with ZFAND2B; probably through VCP (PubMed:24160817). Cytoplasm, cytosol Endoplasmic reticulum Nucleus Note=Associated with the endoplasmic reticulum and nuclear. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P60670-1; Sequence=Displayed; Name=2; IsoId=P60670-2; Sequence=VSP_009790; Binds ubiquitinated proteins via its RanBP2-type zinc finger. Belongs to the NPL4 family. Sequence=BAC98185.1; Type=Erroneous initiation; Evidence=; nucleus cytoplasm endoplasmic reticulum cytosol ubiquitin-dependent protein catabolic process Golgi organization ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol ubiquitin protein ligase binding negative regulation of type I interferon production VCP-NPL4-UFD1 AAA ATPase complex UFD1-NPL4 complex negative regulation of RIG-I signaling pathway nuclear outer membrane-endoplasmic reticulum membrane network ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process macromolecular complex binding metal ion binding ATPase binding K48-linked polyubiquitin binding K63-linked polyubiquitin binding uc007msq.1 uc007msq.2 uc007msq.3 uc007msq.4 
ENSMUST00000044277.10 Chmp4b ENSMUST00000044277.10 charged multivesicular body protein 4B (from RefSeq NM_029362.4) A2AVM1 CHM4B_MOUSE ENSMUST00000044277.1 ENSMUST00000044277.2 ENSMUST00000044277.3 ENSMUST00000044277.4 ENSMUST00000044277.5 ENSMUST00000044277.6 ENSMUST00000044277.7 ENSMUST00000044277.8 ENSMUST00000044277.9 NM_029362 Q3TXM7 Q91VM7 Q922P1 Q9D8B3 uc008njq.1 uc008njq.2 uc008njq.3 Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan. Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with CHMP6 and CHMP4C. Interacts with PDCD6IP; the interaction is direct. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with CHMP7. Interacts with CFTR; the interaction requires misfolded CFTR. Interacts with PTPN23 (By similarity). Q9D8B3; Q8WUM4: PDCD6IP; Xeno; NbExp=2; IntAct=EBI-8322817, EBI-310624; Cytoplasm, cytosol Late endosome membrane ; Peripheral membrane protein Midbody Nucleus envelope Note=Recruited to the nuclear envelope by CHMP7 during late anaphase. Localizes transiently to the midbody arms immediately before abscission. The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity). ISGylated. Isgylation weakens its interaction with VPS4A (By similarity). Belongs to the SNF7 family. Sequence=AAH06905.1; Type=Erroneous initiation; Evidence=; Sequence=AK008205; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; mitotic cytokinesis ESCRT III complex protein binding nucleus nuclear envelope cytoplasm endosome cytosol posttranslational protein targeting to membrane autophagy nucleus organization vacuolar transport mitotic metaphase plate congression cytoplasmic side of plasma membrane exit from mitosis regulation of autophagy regulation of centrosome duplication postsynaptic density protein transport membrane membrane coat midbody nuclear envelope reassembly late endosome membrane vesicle maintenance of lens transparency viral budding via host ESCRT complex identical protein binding protein homodimerization activity viral budding regulation of viral process protein homooligomerization negative regulation of cell death membrane fission ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway glutamatergic synapse negative regulation of neuron death regulation of mitotic spindle assembly positive regulation of viral release from host cell negative regulation of autophagosome assembly uc008njq.1 uc008njq.2 uc008njq.3 
ENSMUST00000044278.6 St6galnac5 ENSMUST00000044278.6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (from RefSeq NM_012028.5) ENSMUST00000044278.1 ENSMUST00000044278.2 ENSMUST00000044278.3 ENSMUST00000044278.4 ENSMUST00000044278.5 NM_012028 Q6GTI0 Q6GTI0_MOUSE St6galnac5 uc008rtu.1 uc008rtu.2 uc008rtu.3 uc008rtu.4 Reaction=a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41968, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568, ChEBI:CHEBI:78569; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41969; Evidence=; Membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 29 family. Golgi apparatus protein glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups sialylation uc008rtu.1 uc008rtu.2 uc008rtu.3 uc008rtu.4 
ENSMUST00000044297.7 Igfbpl1 ENSMUST00000044297.7 insulin-like growth factor binding protein-like 1 (from RefSeq NM_018741.2) ENSMUST00000044297.1 ENSMUST00000044297.2 ENSMUST00000044297.3 ENSMUST00000044297.4 ENSMUST00000044297.5 ENSMUST00000044297.6 IBPL1_MOUSE Igfbprp4 NM_018741 Q80W15 uc008ssy.1 uc008ssy.2 uc008ssy.3 IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). Secreted regulation of cell growth insulin-like growth factor binding extracellular region extracellular space cellular response to tumor cell uc008ssy.1 uc008ssy.2 uc008ssy.3 
ENSMUST00000044306.13 Grm1 ENSMUST00000044306.13 glutamate receptor, metabotropic 1, transcript variant 1 (from RefSeq NM_016976.3) ENSMUST00000044306.1 ENSMUST00000044306.10 ENSMUST00000044306.11 ENSMUST00000044306.12 ENSMUST00000044306.2 ENSMUST00000044306.3 ENSMUST00000044306.4 ENSMUST00000044306.5 ENSMUST00000044306.6 ENSMUST00000044306.7 ENSMUST00000044306.8 ENSMUST00000044306.9 GRM1_MOUSE Gprc1a Mglur1 NM_016976 P97772 Q6AXG4 Q9EPV6 uc007eji.1 uc007eji.2 uc007eji.3 uc007eji.4 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity). May function in the light response in the retina (PubMed:26427409). Homodimer; disulfide-linked (By similarity). The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with TAMALIN (By similarity). Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with SHIA1 (By similarity). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=P97772-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P97772-2; Sequence=VSP_007186, VSP_007187; Name=3; Synonyms=E55; IsoId=P97772-3; Sequence=VSP_007184, VSP_007185; Expressed in the striatum (at protein level). Belongs to the G-protein coupled receptor 3 family. activation of MAPKK activity activation of MAPK activity PLC activating G-protein coupled glutamate receptor activity G-protein coupled receptor activity protein binding nucleus plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway locomotory behavior glutamate receptor activity postsynaptic density membrane integral component of membrane sensory perception of pain calcium-mediated signaling estrogen receptor binding axon dendrite G-protein coupled receptor dimeric complex G-protein coupled receptor homodimeric complex presynaptic membrane identical protein binding neuron projection neuronal cell body dendritic spine regulation of MAPK cascade postsynaptic membrane positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway regulation of sensory perception of pain regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential cellular response to electrical stimulus postsynaptic density membrane G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration glutamatergic synapse integral component of postsynaptic membrane integral component of postsynaptic density membrane G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential regulation of postsynaptic cytosolic calcium ion concentration neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration uc007eji.1 uc007eji.2 uc007eji.3 uc007eji.4 
ENSMUST00000044311.9 Colgalt2 ENSMUST00000044311.9 collagen beta(1-O)galactosyltransferase 2, transcript variant 1 (from RefSeq NM_177756.5) ENSMUST00000044311.1 ENSMUST00000044311.2 ENSMUST00000044311.3 ENSMUST00000044311.4 ENSMUST00000044311.5 ENSMUST00000044311.6 ENSMUST00000044311.7 ENSMUST00000044311.8 GT252_MOUSE Glt25d2 NM_177756 Q6NVG7 Q8BWD4 uc007czg.1 uc007czg.2 uc007czg.3 uc007czg.4 Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen. Reaction=(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP; Xref=Rhea:RHEA:12637, Rhea:RHEA-COMP:12752, Rhea:RHEA- COMP:12753, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:133442, ChEBI:CHEBI:133443; EC=2.4.1.50; Evidence=; Endoplasmic reticulum lumen Belongs to the glycosyltransferase 25 family. cellular_component endoplasmic reticulum endoplasmic reticulum lumen biological_process transferase activity transferase activity, transferring glycosyl groups procollagen galactosyltransferase activity uc007czg.1 uc007czg.2 uc007czg.3 uc007czg.4 
ENSMUST00000044326.5 2300002M23Rik ENSMUST00000044326.5 RIKEN cDNA 2300002M23 gene (from RefSeq NM_175148.3) CF015_MOUSE ENSMUST00000044326.1 ENSMUST00000044326.2 ENSMUST00000044326.3 ENSMUST00000044326.4 NM_175148 Q3KNI3 Q3KNI4 Q8BM15 Stg uc008cib.1 uc008cib.2 uc008cib.3 Binds to numerous extracellular matrix proteins. Secreted, extracellular space, extracellular matrix At 16.5 dpc, present in rib cartilage (at protein level). fibronectin binding collagen binding glycosaminoglycan binding hyaluronic acid binding extracellular region interstitial matrix heparin binding extracellular matrix organization extracellular matrix laminin binding collagen V binding uc008cib.1 uc008cib.2 uc008cib.3 
ENSMUST00000044332.16 Cerk ENSMUST00000044332.16 ceramide kinase (from RefSeq NM_145475.4) CERK1_MOUSE ENSMUST00000044332.1 ENSMUST00000044332.10 ENSMUST00000044332.11 ENSMUST00000044332.12 ENSMUST00000044332.13 ENSMUST00000044332.14 ENSMUST00000044332.15 ENSMUST00000044332.2 ENSMUST00000044332.3 ENSMUST00000044332.4 ENSMUST00000044332.5 ENSMUST00000044332.6 ENSMUST00000044332.7 ENSMUST00000044332.8 ENSMUST00000044332.9 NM_145475 Q52KP2 Q8K4Q7 uc007xdy.1 uc007xdy.2 uc007xdy.3 uc007xdy.4 Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:16269826). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8- dihydroceramide), to a lesser extent on C2-ceramide and C6- dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:16269826). Shows a greater preference for D-erythro isomer of ceramides (By similarity). Binds phosphoinositides (By similarity). Reaction=an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+); Xref=Rhea:RHEA:17929, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52639, ChEBI:CHEBI:57674, ChEBI:CHEBI:456216; EC=2.7.1.138; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17930; Evidence=; Reaction=ATP + N-(hexanoyl)sphing-4-enine = ADP + H(+) + N- hexanoylsphing-4-enine 1-phosphate; Xref=Rhea:RHEA:43312, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:63867, ChEBI:CHEBI:82959, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43313; Evidence=; Reaction=ATP + N-(acetyl)-sphing-4-enine = ADP + H(+) + N-(acetyl)- sphing-4-enine-1-phosphate; Xref=Rhea:RHEA:47904, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46979, ChEBI:CHEBI:85375, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47905; Evidence=; Reaction=ATP + N-hexadecanoylsphing-4-enine = ADP + H(+) + N- (hexadecanoyl)-sphing-4-enine-1-phosphate; Xref=Rhea:RHEA:46340, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:72959, ChEBI:CHEBI:72963, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46341; Evidence=; Reaction=ATP + N-hexanoyl-(4R)-hydroxysphinganine = ADP + H(+) + N- hexanoyl-(4R)-hydroxysphinganine-1-phosphate; Xref=Rhea:RHEA:47916, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:88095, ChEBI:CHEBI:88096, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47917; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm Cell membrane ; Peripheral membrane protein High level expression in heart, brain, testis and pancreas; low expression in spleen, liver and lung; not detected in skeletal muscle. Highly expressed at 7 dpc and decreases rapidly thereafter. nucleotide binding magnesium ion binding ceramide kinase activity NAD+ kinase activity ATP binding cytoplasm mitochondrion plasma membrane ceramide metabolic process membrane integral component of membrane kinase activity phosphorylation transferase activity lipid phosphorylation uc007xdy.1 uc007xdy.2 uc007xdy.3 uc007xdy.4 
ENSMUST00000044352.9 Pcnx4 ENSMUST00000044352.9 pecanex homolog 4, transcript variant 1 (from RefSeq NM_026327.4) 1810048J11Rik E9QN69 E9QN69_MOUSE ENSMUST00000044352.1 ENSMUST00000044352.2 ENSMUST00000044352.3 ENSMUST00000044352.4 ENSMUST00000044352.5 ENSMUST00000044352.6 ENSMUST00000044352.7 ENSMUST00000044352.8 NM_026327 Pcnx4 Pcnxl4 uc007nvr.1 uc007nvr.2 uc007nvr.3 uc007nvr.4 Membrane ulti-pass membrane protein Belongs to the pecanex family. membrane integral component of membrane uc007nvr.1 uc007nvr.2 uc007nvr.3 uc007nvr.4 
ENSMUST00000044355.11 Selenow ENSMUST00000044355.11 selenoprotein W (from RefSeq NM_009156.2) ENSMUST00000044355.1 ENSMUST00000044355.10 ENSMUST00000044355.2 ENSMUST00000044355.3 ENSMUST00000044355.4 ENSMUST00000044355.5 ENSMUST00000044355.6 ENSMUST00000044355.7 ENSMUST00000044355.8 ENSMUST00000044355.9 NM_009156 O35965 P49904 P63300 Q9JIC2 SELW_MOUSE Selenow Selw Sepw1 uc009fgp.1 uc009fgp.2 uc009fgp.3 This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, and has been shown to function as a glutathione-dependent antioxidant in vivo. Studies in mouse suggest that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. [provided by RefSeq, Apr 2017]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF015284.1, BU524484.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID:9256076) protein contains selenocysteine :: PMID: 9256076, 12062442 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency. Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90. Cytoplasm. In the embryo, expressed in the developing nervous system and in mesoderm-derived tissues such as heart and limbs. In the adult, predominantly expressed in brain, skeletal muscle and heart. Expression is first detected in the newly implanted embryo. Levels increase gradually during embryonic development with a steady increase during the second week and a dramatic increase by the end of gestation. Expression increases gradually in proliferating myotubes but is low in terminally differentiated myobutubes. Down-regulated by hydrogen peroxide. Increased levels are detected after treatment with L-buthionine sulfoxide (BSO) before exposure to hydrogen peroxide. Belongs to the SelWTH family. Selenoprotein W subfamily. cytoplasm plasma membrane response to selenium ion antioxidant activity oxidoreductase activity oxidation-reduction process cellular oxidant detoxification uc009fgp.1 uc009fgp.2 uc009fgp.3 
ENSMUST00000044373.6 Rfxap ENSMUST00000044373.6 regulatory factor X-associated protein (from RefSeq NM_133231.2) ENSMUST00000044373.1 ENSMUST00000044373.2 ENSMUST00000044373.3 ENSMUST00000044373.4 ENSMUST00000044373.5 NM_133231 Q8VCG9 Q91Y54 RFXAP_MOUSE uc008pfw.1 uc008pfw.2 Part of the RFX complex that binds to the X-box of MHC II promoters. RFX consists of at least 3 different subunits; RFXAP, RFX5 and RFX-B/RFXANK; with each subunit representing a separate complementation group. RFX forms cooperative DNA binding complexes with X2BP and CBF/NF-Y. RFX associates with CIITA to form an active transcriptional complex (By similarity). Nucleus Phosphorylated. DNA binding nucleus nuclear speck positive regulation of transcription, DNA-templated uc008pfw.1 uc008pfw.2 
ENSMUST00000044380.8 Foxa1 ENSMUST00000044380.8 forkhead box A1 (from RefSeq NM_008259.4) ENSMUST00000044380.1 ENSMUST00000044380.2 ENSMUST00000044380.3 ENSMUST00000044380.4 ENSMUST00000044380.5 ENSMUST00000044380.6 ENSMUST00000044380.7 FOXA1_MOUSE Hnf3a NM_008259 P35582 Q4VA63 Q61108 Tcf-3a Tcf3a uc007nps.1 uc007nps.2 uc007nps.3 uc007nps.4 Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas, lungs and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles. Plays a role in prostate morphogenesis and epithelial cell differentiation. FOXA1 and FOXA2 are essential for hepatic specification. FOXA1 and FOXA2 are required for morphogenesis and cell differentiation during formation of the lung. FOXA1 and FOXA2 are involved in bile duct formation; they positively regulate the binding of glucocorticoid receptor/NR3C1 to the IL6 promoter. FOXA1 and FOXA2 regulate multiple phases of midbrain dopaminergic neuron development; they regulate expression of NEUROG2 at the beginning of mDA neurogenesis and of NR4A2 and EN1 in immature mDA neurons. Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription. Inhibits NKX2-1-mediated transcription from the SFTPC promoter in lung epithel independently from DNA-binding. Involved in regulation of apoptosis. Involved in cell cycle regulation. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates the GCG promoter. Binds DNA as a monomer. Interacts with FOXA2. Interacts with NKX2-1. Interacts with HDAC7. Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A. Interacts with AR. Interacts with NR0B2 (By similarity). Nucleus Restricted mainly to endoderm-derived tissues (lung, liver, stomach, and small intestine). Expressed in the prostate. Most abundant in midgestation embryos (day 9.5). In embryonic lung expressed at 12 dpc and 18 dpc with highest levels in proximal airways and lowest levels in the distal lung. The prostate shows a severely altered ductal pattern that resembles primitive epithelial cords surrounded by thick stromal layers; no differentiated or mature luminal epithelial cells are found. Dehydration and electrolyte imbalance, development of mild nephrogenic diabetes insipidus. Severe hypoglycemia due to at least in part diminished expression of GCG. Mice deficient for Fox1a and deficient for Foxa2 in the endoderm from 8.5 dpc onwards do not show hepatic bud formation. Mice deficient for Fox1a and deficient for Foxa2 in the midbrain from 10.5 dpc onwards show almost complete loss of mDA neurons. Mice deficient for Fox1a and deficient for Foxa2 in the embryonic liver show hyperplasia of the biliary tree due to at least in part activation of IL-6 expression, a proliferative signal for cholangiocytes. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding fibrillar center DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm microvillus chromatin organization chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Notch signaling pathway multicellular organism development transcription factor binding anatomical structure morphogenesis regulation of gene expression negative regulation of epithelial to mesenchymal transition protein domain specific binding dorsal/ventral neural tube patterning cell differentiation lung development response to estradiol positive regulation of intracellular estrogen receptor signaling pathway tube morphogenesis hormone metabolic process glucose homeostasis positive regulation of apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of neuron differentiation positive regulation of smoothened signaling pathway positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter anatomical structure formation involved in morphogenesis neuron fate specification positive regulation of sequence-specific DNA binding transcription factor activity regulation of cell cycle lung morphogenesis epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development epithelial-mesenchymal signaling involved in prostate gland development prostate gland epithelium morphogenesis prostate gland stromal morphogenesis epithelial cell maturation involved in prostate gland development alveolar secondary septum development connective tissue development respiratory basal cell differentiation uc007nps.1 uc007nps.2 uc007nps.3 uc007nps.4 
ENSMUST00000044382.7 Zc4h2 ENSMUST00000044382.7 zinc finger, C4H2 domain containing, transcript variant 1 (from RefSeq NM_001003916.2) B1AUU6 ENSMUST00000044382.1 ENSMUST00000044382.2 ENSMUST00000044382.3 ENSMUST00000044382.4 ENSMUST00000044382.5 ENSMUST00000044382.6 Hca127 Kiaa1166 NM_001003916 Q3TSJ9 Q3U274 Q504M3 Q68FG0 Q6ZPW6 ZC4H2_MOUSE uc009ttz.1 uc009ttz.2 uc009ttz.3 uc009ttz.4 uc009ttz.5 Plays a role in interneurons differentiation. Involved in neuronal development and in neuromuscular junction formation. Cytoplasm Nucleus Postsynaptic cell membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q68FG0-1; Sequence=Displayed; Name=2; IsoId=Q68FG0-2; Sequence=VSP_013470; Expressed in embryonic and adult brain and spinal cord. In all brain areas, expression levels are high during embryonic development and decrease postanatally. Sequence=BAC98112.1; Type=Erroneous initiation; Evidence=; molecular_function nucleus cytoplasm plasma membrane multicellular organism development nervous system development neuromuscular junction development membrane spinal cord motor neuron differentiation cell junction cell differentiation synapse postsynaptic membrane positive regulation of neuron differentiation metal ion binding uc009ttz.1 uc009ttz.2 uc009ttz.3 uc009ttz.4 uc009ttz.5 
ENSMUST00000044384.5 Aldh1b1 ENSMUST00000044384.5 aldehyde dehydrogenase 1 family, member B1 (from RefSeq NM_028270.4) AL1B1_MOUSE Aldhx ENSMUST00000044384.1 ENSMUST00000044384.2 ENSMUST00000044384.3 ENSMUST00000044384.4 NM_028270 Q3UAH5 Q9CZS1 uc008ssx.1 uc008ssx.2 uc008ssx.3 ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (By similarity). Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. Homotetramer. Mitochondrion matrix Belongs to the aldehyde dehydrogenase family. aldehyde dehydrogenase (NAD) activity nucleoplasm mitochondrion mitochondrial matrix ethanol catabolic process oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor intracellular membrane-bounded organelle glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity oxidation-reduction process uc008ssx.1 uc008ssx.2 uc008ssx.3 
ENSMUST00000044385.14 Sgtb ENSMUST00000044385.14 small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta, transcript variant 1 (from RefSeq NM_144838.2) ENSMUST00000044385.1 ENSMUST00000044385.10 ENSMUST00000044385.11 ENSMUST00000044385.12 ENSMUST00000044385.13 ENSMUST00000044385.2 ENSMUST00000044385.3 ENSMUST00000044385.4 ENSMUST00000044385.5 ENSMUST00000044385.6 ENSMUST00000044385.7 ENSMUST00000044385.8 ENSMUST00000044385.9 NM_144838 Q8VD33 SGTB_MOUSE uc007rss.1 uc007rss.2 uc007rss.3 uc007rss.4 Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. Homooligomerize. Belongs to the SGT family. cytosol posttranslational protein targeting to membrane membrane ER-associated ubiquitin-dependent protein catabolic process protein homodimerization activity protein heterodimerization activity TRC complex positive regulation of chaperone-mediated protein folding uc007rss.1 uc007rss.2 uc007rss.3 uc007rss.4 
ENSMUST00000044392.11 Kyat3 ENSMUST00000044392.11 kynurenine aminotransferase 3, transcript variant 2 (from RefSeq NM_173763.4) Ccbl2 ENSMUST00000044392.1 ENSMUST00000044392.10 ENSMUST00000044392.2 ENSMUST00000044392.3 ENSMUST00000044392.4 ENSMUST00000044392.5 ENSMUST00000044392.6 ENSMUST00000044392.7 ENSMUST00000044392.8 ENSMUST00000044392.9 KAT3_MOUSE Kat3 NM_173763 Q71RI9 Q8BJ84 uc008roz.1 uc008roz.2 uc008roz.3 uc008roz.4 Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19029248). May catalyze the beta-elimination of S- conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:19029248). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (PubMed:19029248). Reaction=2-oxoglutarate + L-kynurenine = H2O + kynurenate + L- glutamate; Xref=Rhea:RHEA:65560, ChEBI:CHEBI:15377, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454; EC=2.6.1.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65561; Evidence=; Reaction=glyoxylate + L-kynurenine = glycine + H2O + kynurenate; Xref=Rhea:RHEA:65896, ChEBI:CHEBI:15377, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454; EC=2.6.1.63; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65897; Evidence=; Reaction=3-hydroxy-L-kynurenine + glyoxylate = glycine + H2O + xanthurenate; Xref=Rhea:RHEA:65900, ChEBI:CHEBI:15377, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:58125, ChEBI:CHEBI:71201; EC=2.6.1.63; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65901; Evidence=; Reaction=an S-substituted L-cysteine + H2O = a thiol + NH4(+) + pyruvate; Xref=Rhea:RHEA:18121, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29256, ChEBI:CHEBI:58717; EC=4.4.1.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18122; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Kynurenine transamination is competitively inhibited by cysteine, glutamine, histidine, methionine, leucine, or phenylalanine. Kinetic parameters: KM=0.7 mM for glutamine ; KM=0.7 mM for histidine ; KM=0.7 mM for cysteine ; KM=0.9 mM for methionine ; KM=1.1 mM for phenylalanine ; KM=1.4 mM for asparagine ; KM=1.5 mM for kynurenine ; KM=7.1 mM for tryptophan ; KM=3.0 mM for serine ; KM=0.4 mM for glyoxylate ; KM=0.6 mM for phenylpyruvate ; pH dependence: Optimum pH is 9. ; Temperature dependence: Optimum temperature is 60 degrees Celsius. ; Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2. Homodimer. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q71RI9-1; Sequence=Displayed; Name=2; IsoId=Q71RI9-2; Sequence=VSP_025605; Widely expressed, with higher expression levels in liver, kidney, heart and neuroendocrine tissues. Expressed from postnatal day (PND) 7 and peaks in adult. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. catalytic activity cytoplasm mitochondrion 2-oxoglutarate metabolic process cellular amino acid metabolic process transaminase activity biosynthetic process kynurenine-oxoglutarate transaminase activity transferase activity lyase activity pyridoxal phosphate binding kynurenine aminotransferase activity protein homodimerization activity kynurenine-glyoxylate transaminase activity cysteine-S-conjugate beta-lyase activity kynurenine metabolic process L-kynurenine metabolic process uc008roz.1 uc008roz.2 uc008roz.3 uc008roz.4 
ENSMUST00000044405.8 Lpar6 ENSMUST00000044405.8 lysophosphatidic acid receptor 6 (from RefSeq NM_175116.4) A6H6N5 ENSMUST00000044405.1 ENSMUST00000044405.2 ENSMUST00000044405.3 ENSMUST00000044405.4 ENSMUST00000044405.5 ENSMUST00000044405.6 ENSMUST00000044405.7 LPAR6_MOUSE NM_175116 P2ry5 P2y5 Q3TEJ6 Q8BMC0 uc007upq.1 uc007upq.2 uc007upq.3 uc007upq.4 Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity). Cell membrane; Multi-pass membrane protein. Ubiquitously expressed. Detected in the hair follicles and skin (at protein level). Belongs to the G-protein coupled receptor 1 family. blastocyst hatching G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane positive regulation of Rho protein signal transduction intracellular membrane-bounded organelle positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway uc007upq.1 uc007upq.2 uc007upq.3 uc007upq.4 
ENSMUST00000044415.16 Npepl1 ENSMUST00000044415.16 aminopeptidase-like 1, transcript variant 2 (from RefSeq NM_213733.2) A2ACM6 ENSMUST00000044415.1 ENSMUST00000044415.10 ENSMUST00000044415.11 ENSMUST00000044415.12 ENSMUST00000044415.13 ENSMUST00000044415.14 ENSMUST00000044415.15 ENSMUST00000044415.2 ENSMUST00000044415.3 ENSMUST00000044415.4 ENSMUST00000044415.5 ENSMUST00000044415.6 ENSMUST00000044415.7 ENSMUST00000044415.8 ENSMUST00000044415.9 NM_213733 PEPL1_MOUSE Q66JY0 Q6NSR8 uc008oeo.1 uc008oeo.2 uc008oeo.3 uc008oeo.4 Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Belongs to the peptidase M17 family. aminopeptidase activity cytoplasm proteolysis biological_process peptidase activity metalloexopeptidase activity hydrolase activity protein metabolic process manganese ion binding metal ion binding uc008oeo.1 uc008oeo.2 uc008oeo.3 uc008oeo.4 
ENSMUST00000044423.4 Brip1 ENSMUST00000044423.4 BRCA1 interacting protein C-terminal helicase 1 (from RefSeq NM_178309.2) Bach1 Brip1 ENSMUST00000044423.1 ENSMUST00000044423.2 ENSMUST00000044423.3 FANCJ_MOUSE Fancj NM_178309 Q5SXJ3 Q8BJQ8 Q8BKI6 uc007ksf.1 uc007ksf.2 uc007ksf.3 uc007ksf.4 This gene encodes a member of the DEAH subfamily of DEAD box helicases. A similar protein in humans is both a DNA-dependent ATPase and a 5-prime-to-3-prime DNA helicase, and plays a role in the repair of DNA double stranded breaks through interaction with the breast cancer-associated tumor suppressor BRCA1. [provided by RefSeq, Feb 2011]. ##Evidence-Data-START## Transcript exon combination :: BC094252.1, AK033205.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the 'Fanconi anemia' pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Binds directly to the BRCT domains of BRCA1. Interacts with the CIA complex components CIAO1, CIAO2B and MMS19. Nucleus Cytoplasm Belongs to the DEAD box helicase family. DEAH subfamily. nucleotide binding nucleic acid binding DNA binding DNA helicase activity chromatin binding RNA helicase activity helicase activity ATP binding nucleus cytoplasm nucleobase-containing compound metabolic process DNA repair nucleotide-excision repair regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus synapsis spermatogenesis spermatogonial cell division spermatid development negative regulation of cell proliferation male gonad development response to toxic substance negative regulation of gene expression meiotic DNA double-strand break processing involved in reciprocal meiotic recombination hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides nuclear membrane DNA duplex unwinding metal ion binding chiasma assembly iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding cellular response to vitamin cellular response to hypoxia seminiferous tubule development cellular response to angiotensin double-strand break repair involved in meiotic recombination uc007ksf.1 uc007ksf.2 uc007ksf.3 uc007ksf.4 
ENSMUST00000044426.8 Guca2b ENSMUST00000044426.8 guanylate cyclase activator 2b (retina) (from RefSeq NM_008191.2) ENSMUST00000044426.1 ENSMUST00000044426.2 ENSMUST00000044426.3 ENSMUST00000044426.4 ENSMUST00000044426.5 ENSMUST00000044426.6 ENSMUST00000044426.7 GCAP2 Guca2b NM_008191 Q9QUQ3 Q9QUQ3_MOUSE uc012dkg.1 uc012dkg.2 uc012dkg.3 uc012dkg.4 This gene encodes a member of the guanylin family and preproprotein that is proteolytically processed to generate a mature protein product. The mature protein product, known as uroguanylin, is an endogenous ligand for the guanylate cyclase-C receptor and may regulate salt and water homeostasis in the intestine and kidneys. Homozygous knockout mice for this gene exhibit impaired sodium chloride excretion and elevated arterial pressure. This gene is present in a gene cluster with a related guanylin family member on chromosome 4. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U90727.1, CF423670.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. Secreted Belongs to the guanylin family. extracellular region cGMP-mediated signaling guanylate cyclase activator activity positive regulation of guanylate cyclase activity uc012dkg.1 uc012dkg.2 uc012dkg.3 uc012dkg.4 
ENSMUST00000044434.13 Crx ENSMUST00000044434.13 cone-rod homeobox, transcript variant 1 (from RefSeq NM_007770.4) Crx ENSMUST00000044434.1 ENSMUST00000044434.10 ENSMUST00000044434.11 ENSMUST00000044434.12 ENSMUST00000044434.2 ENSMUST00000044434.3 ENSMUST00000044434.4 ENSMUST00000044434.5 ENSMUST00000044434.6 ENSMUST00000044434.7 ENSMUST00000044434.8 ENSMUST00000044434.9 NM_007770 Q543C9 Q543C9_MOUSE uc009fgm.1 uc009fgm.2 uc009fgm.3 uc009fgm.4 Nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development sequence-specific DNA binding uc009fgm.1 uc009fgm.2 uc009fgm.3 uc009fgm.4 
ENSMUST00000044441.8 Tmem132d ENSMUST00000044441.8 transmembrane protein 132D (from RefSeq NM_172885.2) B2RU39 ENSMUST00000044441.1 ENSMUST00000044441.2 ENSMUST00000044441.3 ENSMUST00000044441.4 ENSMUST00000044441.5 ENSMUST00000044441.6 ENSMUST00000044441.7 Molt NM_172885 Q76HP3 Q8C422 T132D_MOUSE uc008zse.1 uc008zse.2 uc008zse.3 May serve as a cell-surface marker for oligodendrocyte differentiation. Membrane ; Single-pass type I membrane protein Expressed in mature oligodendrocytes in the white and gray matter of the brain. Belongs to the TMEM132 family. molecular_function negative regulation of phosphatase activity membrane integral component of membrane uc008zse.1 uc008zse.2 uc008zse.3 
ENSMUST00000044442.10 Ptk7 ENSMUST00000044442.10 PTK7 protein tyrosine kinase 7 (from RefSeq NM_175168.4) ENSMUST00000044442.1 ENSMUST00000044442.2 ENSMUST00000044442.3 ENSMUST00000044442.4 ENSMUST00000044442.5 ENSMUST00000044442.6 ENSMUST00000044442.7 ENSMUST00000044442.8 ENSMUST00000044442.9 NM_175168 PTK7_MOUSE Q3V422 Q6W8S9 Q8BKG3 Q8CHK5 Q8K178 uc008cth.1 uc008cth.2 uc008cth.3 uc008cth.4 Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Interacts with CTNNB1. Membrane; Single-pass type I membrane protein. Cell junction Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. Expressed at high levels in lung and un-pregnant uterus among adult tissues, and in the tail, limbs, somites, gut and craniofacial regions among embryonic tissues. The protein kinase domain is predicted to be catalytically inactive. MMP14 cleaves PTK7 between Pro-613 and Leu-614 generating an N- terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway. Mice die perinatally and display craniorachischisis, a severe form of neural tube defect in which the neural tube fails to close from the midbrain hindbrain boundary to the base of the spine. Chuzhoi mutants also display disruption of planar cell polarity in the inner ear, and defective heart and lung development. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Sequence=AAH27800.1; Type=Erroneous initiation; Evidence=; establishment of planar polarity neural tube closure ventricular septum development axis elongation plasma membrane cell-cell junction cell adhesion heart development positive regulation of neuron projection development membrane integral component of membrane Wnt signaling pathway phosphorylation cell migration peptidyl-tyrosine phosphorylation cell junction actin cytoskeleton reorganization wound healing establishment of epithelial cell apical/basal polarity convergent extension lung-associated mesenchyme development coronary vasculature development cellular response to retinoic acid cochlea morphogenesis planar cell polarity pathway involved in neural tube closure positive regulation of canonical Wnt signaling pathway transmembrane receptor protein tyrosine kinase activity ATP binding protein phosphorylation kinase activity uc008cth.1 uc008cth.2 uc008cth.3 uc008cth.4 
ENSMUST00000044451.4 Naaladl1 ENSMUST00000044451.4 N-acetylated alpha-linked acidic dipeptidase-like 1 (from RefSeq NM_001009546.2) ENSMUST00000044451.1 ENSMUST00000044451.2 ENSMUST00000044451.3 Gm964 NALDL_MOUSE NM_001009546 Naaladasel Q7M758 uc008ghk.1 uc008ghk.2 uc008ghk.3 Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position. Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Homodimer. Apical cell membrane ; Single-pass type II membrane protein Note=Ileal brush border membrane. N-glycosylated. Belongs to the peptidase M28 family. M28B subfamily. aminopeptidase activity carboxypeptidase activity calcium ion binding cellular_component plasma membrane proteolysis peptidase activity metallopeptidase activity zinc ion binding membrane integral component of membrane apical plasma membrane hydrolase activity protein homodimerization activity peptide catabolic process metal ion binding uc008ghk.1 uc008ghk.2 uc008ghk.3 
ENSMUST00000044454.12 Azi2 ENSMUST00000044454.12 5-azacytidine induced gene 2, transcript variant 1 (from RefSeq NM_013727.4) AZI2_MOUSE Az2 ENSMUST00000044454.1 ENSMUST00000044454.10 ENSMUST00000044454.11 ENSMUST00000044454.2 ENSMUST00000044454.3 ENSMUST00000044454.4 ENSMUST00000044454.5 ENSMUST00000044454.6 ENSMUST00000044454.7 ENSMUST00000044454.8 ENSMUST00000044454.9 NM_013727 Nap1 Q3TIN1 Q3V3R2 Q9CUI5 Q9QYP6 Tbkp2 uc009rzj.1 uc009rzj.2 uc009rzj.3 uc009rzj.4 uc009rzj.5 Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. Homodimer (PubMed:17568778). Interacts with IKBKE and TBK1 (PubMed:17568778). Interacts with TICAM1 (By similarity). Interacts with TAX1BP1 (By similarity). Interacts with CALCOCO2 (By similarity). Q9QYP6; O96018: APBA3; Xeno; NbExp=2; IntAct=EBI-6115874, EBI-6115839; Q9QYP6; Q86YT6: MIB1; Xeno; NbExp=2; IntAct=EBI-6115874, EBI-2129148; Q9QYP6; Q9NVV4: MTPAP; Xeno; NbExp=2; IntAct=EBI-6115874, EBI-2556166; Q9QYP6; O75113: N4BP1; Xeno; NbExp=2; IntAct=EBI-6115874, EBI-5278391; Q9QYP6; Q96EP0: RNF31; Xeno; NbExp=2; IntAct=EBI-6115874, EBI-948111; Q9QYP6; Q13114: TRAF3; Xeno; NbExp=2; IntAct=EBI-6115874, EBI-357631; Q9QYP6; P40222: TXLNA; Xeno; NbExp=2; IntAct=EBI-6115874, EBI-359793; Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9QYP6-1; Sequence=Displayed; Name=2; IsoId=Q9QYP6-2; Sequence=VSP_023823, VSP_023824; Name=3; IsoId=Q9QYP6-3; Sequence=VSP_023822; Testis, ovary, heart, lung, kidney and brain. Expressed mainly in the spermatocytes or spermatids in the testis. By 5-azacytidine. Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38, leading to its degradation. [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. mitotic cell cycle cytokine production protein binding cytoplasm I-kappaB kinase/NF-kappaB signaling interferon-alpha production interferon-gamma production interleukin-6 production tumor necrosis factor production T cell activation dendritic cell proliferation dendritic cell differentiation uc009rzj.1 uc009rzj.2 uc009rzj.3 uc009rzj.4 uc009rzj.5 
ENSMUST00000044455.8 Zfp451 ENSMUST00000044455.8 zinc finger protein 451, transcript variant 3 (from RefSeq NM_001290700.1) ENSMUST00000044455.1 ENSMUST00000044455.2 ENSMUST00000044455.3 ENSMUST00000044455.4 ENSMUST00000044455.5 ENSMUST00000044455.6 ENSMUST00000044455.7 NM_001290700 Q8VCL4 Q8VCL4_MOUSE Zfp451 uc007aob.1 uc007aob.2 uc007aob.3 uc007aob.4 uc007aob.1 uc007aob.2 uc007aob.3 uc007aob.4 
ENSMUST00000044462.4 Tcam1 ENSMUST00000044462.4 testicular cell adhesion molecule 1, transcript variant 1 (from RefSeq NM_029467.3) ENSMUST00000044462.1 ENSMUST00000044462.2 ENSMUST00000044462.3 NM_029467 Q99NB3 Q99NB3_MOUSE TCAM-1 Tcam1 uc007lyq.1 uc007lyq.2 uc007lyq.3 Membrane ; Single- pass type I membrane protein Belongs to the immunoglobulin superfamily. ICAM family. integrin binding integral component of plasma membrane cell adhesion membrane integral component of membrane cell-cell adhesion uc007lyq.1 uc007lyq.2 uc007lyq.3 
ENSMUST00000044466.12 Nars2 ENSMUST00000044466.12 asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) (from RefSeq NM_153591.5) ENSMUST00000044466.1 ENSMUST00000044466.10 ENSMUST00000044466.11 ENSMUST00000044466.2 ENSMUST00000044466.3 ENSMUST00000044466.4 ENSMUST00000044466.5 ENSMUST00000044466.6 ENSMUST00000044466.7 ENSMUST00000044466.8 ENSMUST00000044466.9 NM_153591 Nars2 Q8BGV0 SYNM_MOUSE uc009iiw.1 uc009iiw.2 uc009iiw.3 uc009iiw.4 uc009iiw.5 Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the asparagine amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis (By similarity). The reaction occurs in a two steps: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (By similarity). Reaction=ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L- asparaginyl-tRNA(Asn); Xref=Rhea:RHEA:11180, Rhea:RHEA-COMP:9659, Rhea:RHEA-COMP:9674, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58048, ChEBI:CHEBI:78442, ChEBI:CHEBI:78515, ChEBI:CHEBI:456215; EC=6.1.1.22; Evidence=; Homodimer. Mitochondrion matrix Mitochondrion Expressed in brain and inner ear, including the cochlear epithelium and organ of Corti. Belongs to the class-II aminoacyl-tRNA synthetase family. nucleotide binding nucleic acid binding aminoacyl-tRNA ligase activity asparagine-tRNA ligase activity ATP binding nucleoplasm mitochondrion mitochondrial matrix cytosol translation tRNA aminoacylation for protein translation asparaginyl-tRNA aminoacylation ligase activity uc009iiw.1 uc009iiw.2 uc009iiw.3 uc009iiw.4 uc009iiw.5 
ENSMUST00000044475.5 Ogt ENSMUST00000044475.5 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase), transcript variant 1 (from RefSeq NM_139144.4) A2ALY1 ENSMUST00000044475.1 ENSMUST00000044475.2 ENSMUST00000044475.3 ENSMUST00000044475.4 NM_139144 OGT1_MOUSE Q6PG10 Q8BXH6 Q8CGY8 Q91Y38 uc009tyc.1 uc009tyc.2 uc009tyc.3 uc009tyc.4 uc009tyc.5 Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc) (PubMed:29465778). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, AMPK, ATG4B, CAPRIN1, EZH2, FNIP1, RPTOR, HOXA1, PFKL, KMT2E/MLL5, MAPT/TAU, TET2, NOD2 and HCFC1 (By similarity). Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (By similarity). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (By similarity). Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (By similarity). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). O-GlcNAcylation of 'Ser- 75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (By similarity). Stabilizes KMT2E/MLL5 by mediating its glycosylation, thereby preventing KMT2E/MLL5 ubiquitination (By similarity). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver (PubMed:23337503, PubMed:23395176). Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation (PubMed:23337503, PubMed:23395176). Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2 (PubMed:23337503, PubMed:23395176). O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (By similarity). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (By similarity). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Promotes autophagy by mediating O-glycosylation of ATG4B (By similarity). Acts as a regulator of mTORC1 signaling by mediating O-glycosylation of RPTOR and FNIP1: O-GlcNAcylation of RPTOR in response to glucose sufficiency promotes activation of the mTORC1 complex (By similarity). Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N- acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:48904, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:90838; EC=2.4.1.255; Evidence=; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O- (N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:48908, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:12252, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:90840; EC=2.4.1.255; Evidence=; Subject to product inhibition by UDP. Protein modification; protein glycosylation. Monomer; may exist in different oligomerization states in cells (By similarity). Homotrimer, oligomerizes via TPR repeats 6 and 7 (By similarity). Trimerization is not necessary for activity in vitro, however it increases affinity for UDP-GlcNAc (By similarity). Component of a THAP1/THAP3-HCFC1-OGT complex (By similarity). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (By similarity). Found in a complex with KIF5B, RHOT1, RHOT2 and TRAK1 (By similarity). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (PubMed:28554894). Component of a complex composed of KMT2E/MLL5, OGT and USP7; the complex stabilizes KMT2E/MLL5, preventing KMT2E/MLL5 ubiquitination and proteasomal-mediated degradation (By similarity). Interacts (via TPRs 1-6) with SIN3A; the interaction mediates transcriptional repression in parallel with histone deacetylase (By similarity). Interacts (via TPR 5-6) with TET1, TET2 and TET3 (PubMed:23352454). Interacts (via TPR repeats 6 and 7) with ATXN10 (PubMed:16182253). Interacts with NSD2 (PubMed:19483677). Interacts with PROSER1; this interaction mediates TET2 O-GlcNAcylation and stability by promoting the interaction between OGT and TET2 (By similarity). Q8CGY8; Q4JK59: Tet2; NbExp=2; IntAct=EBI-928496, EBI-4291768; Cytoplasm Nucleus Cell membrane Mitochondrion membrane Cell projection Note=Predominantly localizes to the nucleus. Translocates into the nucleus via association with importin KPNA1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CGY8-1; Sequence=Displayed; Name=2; IsoId=Q8CGY8-2; Sequence=VSP_024844; Expression in the liver oscillates in a circadian manner. The TPR repeat domain is required for substrate binding and oligomerization. Ubiquitinated, leading to its proteasomal degradation. Phosphorylation on Ser-3 or Ser-4 by GSK3-beta positively regulates its activity (PubMed:23395175). Phosphorylation at Thr-454 by AMPK promotes nuclear localization (By similarity). Glycosylated via autocatalysis; O-GlcNAcylation at Ser-399 promotes nuclear localization. Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily. histone acetyltransferase complex euchromatin negative regulation of protein phosphorylation positive regulation of protein phosphorylation catalytic activity protein binding phosphatidylinositol-3,4,5-trisphosphate binding nucleus nucleoplasm cytoplasm mitochondrion cytosol plasma membrane glucosamine metabolic process regulation of glycolytic process regulation of gluconeogenesis chromatin organization regulation of transcription from RNA polymerase II promoter protein glycosylation protein O-linked glycosylation apoptotic process N-acetyltransferase activity transcription factor binding lipid binding positive regulation of gene expression negative regulation of peptidyl-threonine phosphorylation membrane protein N-acetylglucosaminyltransferase activity protein processing transferase activity transferase activity, transferring glycosyl groups protein N-acetylglucosaminyltransferase complex protein domain specific binding negative regulation of protein ubiquitination mitochondrial membrane negative regulation of proteasomal ubiquitin-dependent protein catabolic process response to insulin circadian regulation of gene expression macromolecular complex negative regulation of peptidyl-serine phosphorylation regulation of Rac protein signal transduction peptide binding zymogen granule cell projection neuron projection neuronal cell body histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) positive regulation of cell size positive regulation of proteolysis positive regulation of transcription from RNA polymerase II promoter regulation of insulin receptor signaling pathway histone acetyltransferase activity (H4-K16 specific) phosphatidylinositol-mediated signaling monosaccharide binding intracellular distribution of mitochondria rhythmic process negative regulation of cell death positive regulation of histone H3-K27 methylation protein homotrimerization protein heterotrimerization cellular response to lipopolysaccharide cellular response to glucose stimulus histone H3-K4 trimethylation negative regulation of protein targeting to membrane protein O-GlcNAc transferase activity negative regulation of cellular response to hypoxia positive regulation of protein localization to nucleus positive regulation of reactive oxygen species biosynthetic process uc009tyc.1 uc009tyc.2 uc009tyc.3 uc009tyc.4 uc009tyc.5 
ENSMUST00000044478.7 Hibch ENSMUST00000044478.7 3-hydroxyisobutyryl-Coenzyme A hydrolase (from RefSeq NM_146108.2) ENSMUST00000044478.1 ENSMUST00000044478.2 ENSMUST00000044478.3 ENSMUST00000044478.4 ENSMUST00000044478.5 ENSMUST00000044478.6 HIBCH_MOUSE NM_146108 Q8QZS1 uc007ayp.1 uc007ayp.2 uc007ayp.3 uc007ayp.4 Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity). Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2- methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888, ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4; Amino-acid degradation; L-valine degradation. Mitochondrion Belongs to the enoyl-CoA hydratase/isomerase family. 3-hydroxyisobutyryl-CoA hydrolase activity mitochondrion valine catabolic process branched-chain amino acid catabolic process hydrolase activity uc007ayp.1 uc007ayp.2 uc007ayp.3 uc007ayp.4 
ENSMUST00000044484.13 Kdm6a ENSMUST00000044484.13 lysine (K)-specific demethylase 6A, transcript variant 13 (from RefSeq NM_001403381.1) A2AID2 ENSMUST00000044484.1 ENSMUST00000044484.10 ENSMUST00000044484.11 ENSMUST00000044484.12 ENSMUST00000044484.2 ENSMUST00000044484.3 ENSMUST00000044484.4 ENSMUST00000044484.5 ENSMUST00000044484.6 ENSMUST00000044484.7 ENSMUST00000044484.8 ENSMUST00000044484.9 KDM6A_MOUSE NM_001403381 O70546 Q6DI80 Q7TSG4 Utx uc009ssn.1 uc009ssn.2 uc009ssn.3 Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (PubMed:21095589). Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)- [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- lysyl(27)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60224, Rhea:RHEA-COMP:15535, Rhea:RHEA-COMP:15544, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961; EC=1.14.11.68; Evidence=; Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A (or KDM6B), PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity). Interacts with TLE1 (PubMed:9854018). Interacts with SUPT6H (PubMed:23503590). Interacts with SMARCA4 (PubMed:21095589). Interacts with PROSER1 (By similarity). O70546; Q61321: Six4; NbExp=2; IntAct=EBI-1573712, EBI-986524; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O70546-1; Sequence=Displayed; Name=2; IsoId=O70546-2; Sequence=VSP_022196; Expressed in brain, heart and spleen. Widely expressed at 13.5 dpc. Escapes X chromosome inactivation. Belongs to the UTX family. Sequence=AAH75703.1; Type=Miscellaneous discrepancy; Evidence=; nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding in utero embryonic development neural tube closure heart morphogenesis respiratory system process chromatin binding protein binding nucleus nucleoplasm chromatin organization chromatin remodeling heart development regulation of gene expression positive regulation of gene expression oxidoreductase activity neural tube development chromatin DNA binding somite rostral/caudal axis specification histone methyltransferase complex multicellular organism growth identical protein binding sequence-specific DNA binding MLL3/4 complex metal ion binding mesodermal cell differentiation embryonic organ development notochord morphogenesis dioxygenase activity oxidation-reduction process canonical Wnt signaling pathway histone H3-K27 demethylation histone demethylase activity (H3-K27 specific) cardiovascular system development uc009ssn.1 uc009ssn.2 uc009ssn.3 
ENSMUST00000044491.13 Minar1 ENSMUST00000044491.13 membrane integral NOTCH2 associated receptor 1 (from RefSeq NM_153509.2) ENSMUST00000044491.1 ENSMUST00000044491.10 ENSMUST00000044491.11 ENSMUST00000044491.12 ENSMUST00000044491.2 ENSMUST00000044491.3 ENSMUST00000044491.4 ENSMUST00000044491.5 ENSMUST00000044491.6 ENSMUST00000044491.7 ENSMUST00000044491.8 ENSMUST00000044491.9 MNAR1_MOUSE NM_153509 Q14CG5 Q69ZS9 Q8K3V7 Ubtor uc009qzn.1 uc009qzn.2 uc009qzn.3 uc009qzn.4 uc009qzn.5 Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR. Negatively regulates angiogenesis. Negatively regulates cell growth (By similarity). Negatively regulates neurite outgrowth in hippocampal neurons (By similarity). Interacts with NOTCH2; this interaction increases MINAR1 stability. Interacts (via N-terminus) with DEPTOR (via PDZ domain); this interaction may stabilize DEPTOR protein by impairing its ubiquitination. Cell membrane ; Single-pass type IV membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K3V7-1; Sequence=Displayed; Name=2; IsoId=Q8K3V7-2; Sequence=VSP_013706; Expressed in brain and in islets of Langerhans. Belongs to the MINAR family. MINAR1 topology is a matter of debate, some authors think the N-terminus is extracellular, while preliminary experimental results suggest a cytosolic location. Sequence=BAD32367.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; angiogenesis molecular_function plasma membrane negative regulation of cell proliferation negative regulation of neuron projection development membrane integral component of membrane negative regulation of angiogenesis negative regulation of cell growth negative regulation of protein ubiquitination negative regulation of TOR signaling uc009qzn.1 uc009qzn.2 uc009qzn.3 uc009qzn.4 uc009qzn.5 
ENSMUST00000044492.10 Akap9 ENSMUST00000044492.10 A kinase anchor protein 9 (from RefSeq NM_194462.2) Akap9 E9QQ10 E9QQ10_MOUSE ENSMUST00000044492.1 ENSMUST00000044492.2 ENSMUST00000044492.3 ENSMUST00000044492.4 ENSMUST00000044492.5 ENSMUST00000044492.6 ENSMUST00000044492.7 ENSMUST00000044492.8 ENSMUST00000044492.9 NM_194462 uc008wid.1 uc008wid.2 uc008wid.3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Golgi apparatus Golgi stack cis-Golgi network centrosome microtubule nucleation signal transduction negative regulation of adenylate cyclase activity voltage-gated potassium channel complex potassium channel regulator activity positive regulation of microtubule polymerization positive regulation of peptidyl-serine phosphorylation protein kinase A regulatory subunit binding neuronal cell body intracellular membrane-bounded organelle dendritic branch ion channel binding response to electrical stimulus maintenance of centrosome location binding, bridging regulation of membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization cellular response to cAMP regulation of heart rate by cardiac conduction synaptic membrane regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of postsynaptic neurotransmitter receptor activity glutamatergic synapse positive regulation of potassium ion transmembrane transporter activity regulation of Golgi organization uc008wid.1 uc008wid.2 uc008wid.3 
ENSMUST00000044503.14 Rftn1 ENSMUST00000044503.14 raftlin lipid raft linker 1 (from RefSeq NM_181397.2) ENSMUST00000044503.1 ENSMUST00000044503.10 ENSMUST00000044503.11 ENSMUST00000044503.12 ENSMUST00000044503.13 ENSMUST00000044503.2 ENSMUST00000044503.3 ENSMUST00000044503.4 ENSMUST00000044503.5 ENSMUST00000044503.6 ENSMUST00000044503.7 ENSMUST00000044503.8 ENSMUST00000044503.9 Kiaa0084 NM_181397 Q3U654 Q3U8P6 Q6A0D4 Q80US1 RFTN1_MOUSE uc008cyr.1 uc008cyr.2 uc008cyr.3 Involved in protein trafficking via association with clathrin and AP2 complex (By similarity). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages, and internalization of poly(I:C) to TLR3- positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (PubMed:19414744). May regulate B-cell antigen receptor- mediated signaling (By similarity). May play a pivotal role in the formation and/or maintenance of lipid rafts (By similarity). Interacts with TLR4; the interaction occurs in response to lipopolysaccharide stimulation. Interacts with CLTC; the interaction occurs in response to pathogens. Interacts with AP2A1 and AP2B1. Cell membrane ; Lipid-anchor Cytoplasm Membrane raft Endosome Early endosome Note=Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3. Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation (PubMed:27022195). Expressed in T-cells, B-cells, thymus and spleen (at protein level) (PubMed:19414744, PubMed:12805216). Expressed in dendritic cells, macrophages, heart, lung and small intestine (PubMed:19414744). Mutant mice have smaller spleen, fewer splenocytes, reduced IgM production and secrete less IFNG, during antigen re-stimulation (PubMed:19414744). Double RFTN1 and RFTN2 mutant mice show no visible phenotype under pathogen-free conditions but show greatly reduced IFNB1 production in splenic dendritic cells following poly(I:C) or LPS stimulation (PubMed:27022195). Belongs to the raftlin family. Sequence=BAD32162.1; Type=Erroneous initiation; Evidence=; Sequence=BAE31871.1; Type=Erroneous initiation; Evidence=; membrane raft assembly T cell antigen processing and presentation double-stranded RNA binding cytoplasm endosome early endosome plasma membrane membrane protein transport into membrane raft interleukin-17 production macromolecular complex dsRNA transport toll-like receptor 3 signaling pathway positive regulation of growth rate response to exogenous dsRNA membrane raft T cell receptor signaling pathway B cell receptor signaling pathway protein localization to membrane raft uc008cyr.1 uc008cyr.2 uc008cyr.3 
ENSMUST00000044507.12 Inpp5j ENSMUST00000044507.12 inositol polyphosphate 5-phosphatase J (from RefSeq NM_172439.3) ENSMUST00000044507.1 ENSMUST00000044507.10 ENSMUST00000044507.11 ENSMUST00000044507.2 ENSMUST00000044507.3 ENSMUST00000044507.4 ENSMUST00000044507.5 ENSMUST00000044507.6 ENSMUST00000044507.7 ENSMUST00000044507.8 ENSMUST00000044507.9 NM_172439 P59644 PI5PA_MOUSE Pib5pa Q3TDM9 uc007hta.1 uc007hta.2 uc007hta.3 uc007hta.4 Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4- trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. Reaction=1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate; Xref=Rhea:RHEA:19797, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58282, ChEBI:CHEBI:203600; EC=3.1.3.56; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19798; Evidence=; Reaction=1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo- inositol 1,3,4-trisphosphate + phosphate; Xref=Rhea:RHEA:11392, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57895, ChEBI:CHEBI:58414; EC=3.1.3.56; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11393; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol 4-phosphate) + phosphate; Xref=Rhea:RHEA:22764, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456; EC=3.1.3.36; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22765; Evidence=; Cytoplasm Note=Predominantly localized to membrane ruffles. The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein. Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. ruffle phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity cytoplasm plasma membrane negative regulation of neuron projection development hydrolase activity SH3 domain binding extrinsic component of membrane growth cone negative regulation of microtubule polymerization negative regulation of peptidyl-serine phosphorylation phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity dendritic shaft inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity uc007hta.1 uc007hta.2 uc007hta.3 uc007hta.4 
ENSMUST00000044509.7 Tspyl2 ENSMUST00000044509.7 TSPY-like 2, transcript variant 1 (from RefSeq NM_029836.4) Cinap DXBwg1396e Dentt ENSMUST00000044509.1 ENSMUST00000044509.2 ENSMUST00000044509.3 ENSMUST00000044509.4 ENSMUST00000044509.5 ENSMUST00000044509.6 NM_029836 Q6WRI3 Q7TQI8 Q9CU22 TSYL2_MOUSE Tspx uc009uqg.1 uc009uqg.2 uc009uqg.3 Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TBR1 and TSPYL2. Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons. Present at high levels in the pituitary gland and at moderate levels in adrenal gland, brain, testis and ovary. In brain, expressed both in mature neurons and progenitor cells (at protein level). Present widely throughout embryogenesis. Present in developing brain from 10.5 dpc to P7 (at protein level). By TGFB1 or serum in pituitary cell lines (at protein level). Phosphorylation at Thr-333 impairs function on cell proliferation. Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation. Subject to X inactivation. Belongs to the nucleosome assembly protein (NAP) family. nucleus nucleolus cytoplasm chromatin organization nucleosome assembly cell cycle negative regulation of DNA replication negative regulation of cell growth regulation of protein kinase activity uc009uqg.1 uc009uqg.2 uc009uqg.3 
ENSMUST00000044524.16 Dap ENSMUST00000044524.16 death-associated protein (from RefSeq NM_146057.3) DAP1_MOUSE ENSMUST00000044524.1 ENSMUST00000044524.10 ENSMUST00000044524.11 ENSMUST00000044524.12 ENSMUST00000044524.13 ENSMUST00000044524.14 ENSMUST00000044524.15 ENSMUST00000044524.2 ENSMUST00000044524.3 ENSMUST00000044524.4 ENSMUST00000044524.5 ENSMUST00000044524.6 ENSMUST00000044524.7 ENSMUST00000044524.8 ENSMUST00000044524.9 NM_146057 Q91XC8 uc007vkc.1 uc007vkc.2 uc007vkc.3 uc007vkc.4 Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation. Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation. Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). Associates with ribosomes; inhibiting translation. Interacts with eiF5a (EIF5A and EIF5A2); inhibiting translation. Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy. Belongs to the DAP-DAPL1 family. cellular_component autophagy apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of autophagy negative regulation of NF-kappaB transcription factor activity cellular response to amino acid starvation negative regulation of transcription, DNA-templated death domain binding apoptotic signaling pathway uc007vkc.1 uc007vkc.2 uc007vkc.3 uc007vkc.4 
ENSMUST00000044530.3 Smyd4 ENSMUST00000044530.3 SET and MYND domain containing 4 (from RefSeq NM_001102611.1) A2BDD0 ENSMUST00000044530.1 ENSMUST00000044530.2 Kiaa1936 NM_001102611 Q3U3Z8 Q501N5 Q5SWN4 Q69Z60 Q8BMP3 Q8BTK5 SMYD4_MOUSE uc007kdm.1 uc007kdm.2 Plays a critical role in cardiac development (By similarity). Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1 (By similarity). Interacts (via MYND-type zinc finger) with HDAC1. Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BTK5-1; Sequence=Displayed; Name=2; IsoId=Q8BTK5-2; Sequence=VSP_017580; Belongs to the class V-like SAM-binding methyltransferase superfamily. molecular_function cellular_component biological_process methyltransferase activity transferase activity methylation metal ion binding uc007kdm.1 uc007kdm.2 
ENSMUST00000044532.11 Dock3 ENSMUST00000044532.11 dedicator of cyto-kinesis 3 (from RefSeq NM_153413.2) Dock3 ENSMUST00000044532.1 ENSMUST00000044532.10 ENSMUST00000044532.2 ENSMUST00000044532.3 ENSMUST00000044532.4 ENSMUST00000044532.5 ENSMUST00000044532.6 ENSMUST00000044532.7 ENSMUST00000044532.8 ENSMUST00000044532.9 F8VPQ1 F8VPQ1_MOUSE NM_153413 uc009rkv.1 uc009rkv.2 Belongs to the DOCK family. guanyl-nucleotide exchange factor activity cytosol small GTPase mediated signal transduction uc009rkv.1 uc009rkv.2 
ENSMUST00000044533.9 Prss56 ENSMUST00000044533.9 serine protease 56 (from RefSeq NM_027084.2) ENSMUST00000044533.1 ENSMUST00000044533.2 ENSMUST00000044533.3 ENSMUST00000044533.4 ENSMUST00000044533.5 ENSMUST00000044533.6 ENSMUST00000044533.7 ENSMUST00000044533.8 F2YMG0 NM_027084 PRS56_MOUSE Q9CVU9 uc007bwe.1 uc007bwe.2 uc007bwe.3 uc007bwe.4 uc007bwe.5 Serine protease required during eye development. Endoplasmic reticulum membrane ; Peripheral membrane protein Expressed in the eye: present in the retina and in the optic nerve. First detected in the eye at 17 dpc and maintained into adulthood. Mice display the glaucoma-relevant mutant 4 (Grm4) phenotype, with angle-closure glaucoma and eyes having short axial length. High intraocular pressure (IOP) in mutant eyes increases with age and the anterior chambers become enlarged in some eyes at around 3 months of age. Eye's angles are not occluded with abnormal tissue (synechia) and have detectable trabecular meshwork and Schlemm's canal (2 important drainage structures). However, compromised aqueous humor drainage (outflow) contributes to the IOP elevation. After IOP elevation, mutants develop glaucomatous neurodegeneration, which is characterized by retinal ganglion cell death and optic nerve atrophy. Belongs to the peptidase S1 family. Sequence=BAB24587.1; Type=Frameshift; Evidence=; serine-type endopeptidase activity extracellular space endoplasmic reticulum endoplasmic reticulum membrane proteolysis peptidase activity serine-type peptidase activity membrane hydrolase activity camera-type eye development uc007bwe.1 uc007bwe.2 uc007bwe.3 uc007bwe.4 uc007bwe.5 
ENSMUST00000044547.10 Ceacam2 ENSMUST00000044547.10 CEA cell adhesion molecule 2, transcript variant 1 (from RefSeq NM_001113368.1) Bgp2 CEAM2_MOUSE D0VY57 E9QLI9 ENSMUST00000044547.1 ENSMUST00000044547.2 ENSMUST00000044547.3 ENSMUST00000044547.4 ENSMUST00000044547.5 ENSMUST00000044547.6 ENSMUST00000044547.7 ENSMUST00000044547.8 ENSMUST00000044547.9 I7HDK2 NM_001113368 Q61349 Q8R1N5 Q925P2 uc012ffv.1 uc012ffv.2 uc012ffv.3 Controls energy balance and peripheral insulin action. Involved in the regulation of feeding behavior particularly in the ventromedial nucleus of hypothalamus (VMH) regulation of food intake. Has a role in the regulation of metabolic rate and insulin sensitivity or resistance via effects on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, spontaneous activity and energy expenditure in skeletal muscle. In case of murine coronavirus (MHV) infection, does probably not serve as functional receptor for the virus. Isoform 2 may be an adhesion molecule contributing to cell to cell adhesion between elongating spermatids and Sertoli cells within the seminiferous epithelium. Interacts weakly with MHV spike protein in tissue culture. Cell membrane ; Single-pass type I membrane protein Note=Localizes to sites on the plasma membrane of elongating spermatids where Sertoli cells make contact. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Bgp2; IsoId=Q925P2-1; Sequence=Displayed; Name=2; Synonyms=Bgp2, Bgp2L, Ceacam2-Long, Ceacam2-L; IsoId=Q925P2-2; Sequence=VSP_025300; Name=3; Synonyms=Bgp2, Bgp2S, Ceacam2-Short, Ceacam2-S; IsoId=Q925P2-3; Sequence=VSP_025300, VSP_025301; Isoform 2 is detected in elongating spermatids within the seminiferous epithelium (at protein level). Expressed in kidney, colon, uterus, gut mononuclear cells, crypt epithelia of intestinal tissues, and to a lesser extent, in spleen. Expressed in brain including VMH, globus pallidus, ventral pallidum, striatum, olfactory bulb and hippocampus. Also detected in rectal carcinoma cell line CMT93. Isoform 2 and isoform 3 are expressed in testis. Isoform 2 is detected in seminiferous tubule, not detected in epididymal spermatozoa. Also not observed on spermatogonia, spermatocytes, round spermatids or somatic Sertoli cells. During stages I-VII of spermatogenesis, detected on the elongating spermatids. At spermiation (stage VIII) and subsequent stages IX-XII, levels are drastically reduced or absent in the seminiferous tubules. Sometimes weakly detected in the apical region of stage-VIII seminiferous epithelium. Isoform 2 level is very low in stomach, kidney, intestine, liver and spleen. Expressed throughout embryonic development. Isoform 2 first appears faintly in the testis 3 weeks into postnatal development and its expression level increases after 5 weeks. Levels in brain increase at fasting and decrease at 4 and 7 hours of refeeding. Sexually dimorphic effect. Homozygous null mutant female mice exhibit obesity that results from hyperphagia and reduced energy expenditure. Hyperphagia leads to peripheral insulin resistance. Insulin action is normal in liver but is compromised in skeletal muscle; the mice have incomplete fatty acid oxidation and impaired glucose uptake and disposal. Hyperphagia appears to result partly from increased hyperinsulinemia-induced hypothalamic fatty acid synthase levels and activity. Hyperinsulinemia is caused by increased insulin secretion. Homozygous null mutant male mice show total fat mass reduction, which ows to the hypermetabolic state despite hyperphagia. They also exhibit insulin sensitivity with elevated beta-oxidation in skeletal muscle, which is likely to offset the effects of increased food intake. Both males and females have increased brown adipogenesis. However, only males have increased activation of sympathetic tone regulation of adipose tissue and increased spontaneous activity. The human orthologous protein seems not to exist. In mice, both Ceacam1 and Ceacam2 are the paralogs of human CEACAM1. Belongs to the immunoglobulin superfamily. CEA family. actin binding calmodulin binding plasma membrane cell-cell junction adherens junction external side of plasma membrane basal plasma membrane cell surface bile acid transmembrane transporter activity bile acid and bile salt transport membrane integral component of membrane viral process apical plasma membrane lateral plasma membrane kinase binding protein kinase binding protein phosphatase binding cell junction filamin binding identical protein binding protein homodimerization activity protein dimerization activity negative regulation of brown fat cell proliferation energy homeostasis protein tyrosine kinase binding negative regulation of feeding behavior T cell receptor complex homophilic cell adhesion via plasma membrane adhesion molecules uc012ffv.1 uc012ffv.2 uc012ffv.3 
ENSMUST00000044551.8 Cilk1 ENSMUST00000044551.8 ciliogenesis associated kinase 1, transcript variant 2 (from RefSeq NM_019987.2) CILK1_MOUSE ENSMUST00000044551.1 ENSMUST00000044551.2 ENSMUST00000044551.3 ENSMUST00000044551.4 ENSMUST00000044551.5 ENSMUST00000044551.6 ENSMUST00000044551.7 Ick NM_019987 Q8K138 Q9JKV2 uc009qtv.1 uc009qtv.2 uc009qtv.3 uc009qtv.4 uc009qtv.5 Has an essential role in ciliogenesis, particularly in neuronal and retinal progenitor cells (PubMed:24797473). Phosphorylates KIF3A (PubMed:24797473). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (PubMed:24797473, PubMed:24853502). May play a role in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling -dependent manner and this regulation requires its kinase activity (PubMed:25243405). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm, cytosol Cell projection, cilium Nucleus Cytoplasm, cytoskeleton, cilium basal body Note=Also found at the ciliary tip (PubMed:24797473). Predominant nuclear localization has been observed with a N-terminally GFP-tagged construct in transfected COS-7 cells (PubMed:15988018). Highly expressed in colon and lung, lower levels present in heart, esophagus, stomach, small intestine and ovary. Localizes to the crypt region of large and small intestine. At 14.5 dpc, expressed in the brain cortex, including the cortical plate, intermediate zone, and ventricular and subventricular zones. Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-157 by CDK7/Cak1p increases kinase activity. Knockout mice manifest hydrocephalus, polydactyly, and delayed skeletal development. At cellular levels, ICK knockout results in abnormally elongated cilia and compromised SHH signaling. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding magnesium ion binding fibrillar center protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm cytosol cytoskeleton cilium protein phosphorylation signal transduction multicellular organism development regulation of gene expression kinase activity phosphorylation transferase activity cell projection organization intracellular signal transduction intraciliary anterograde transport intraciliary retrograde transport ciliary basal body intraciliary transport cell projection metal ion binding cilium assembly ciliary tip ciliary base uc009qtv.1 uc009qtv.2 uc009qtv.3 uc009qtv.4 uc009qtv.5 
ENSMUST00000044554.5 Ltb4r2 ENSMUST00000044554.5 leukotriene B4 receptor 2 (from RefSeq NM_020490.3) Blt2 ENSMUST00000044554.1 ENSMUST00000044554.2 ENSMUST00000044554.3 ENSMUST00000044554.4 LT4R2_MOUSE NM_020490 Q3KP98 Q9JJL9 uc007uaq.1 uc007uaq.2 Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. leukotriene B4 receptor activity G-protein coupled receptor activity galanin receptor activity leukotriene receptor activity nucleoplasm plasma membrane integral component of plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane keratinocyte migration leukotriene signaling pathway uc007uaq.1 uc007uaq.2 
ENSMUST00000044556.12 Tbc1d13 ENSMUST00000044556.12 TBC1 domain family, member 13 (from RefSeq NM_146252.4) ENSMUST00000044556.1 ENSMUST00000044556.10 ENSMUST00000044556.11 ENSMUST00000044556.2 ENSMUST00000044556.3 ENSMUST00000044556.4 ENSMUST00000044556.5 ENSMUST00000044556.6 ENSMUST00000044556.7 ENSMUST00000044556.8 ENSMUST00000044556.9 NM_146252 Q8R3D1 TBC13_MOUSE uc008jbj.1 uc008jbj.2 uc008jbj.3 Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. Interacts with RAB1A and RAB10; in a GTP-dependent manner. Membrane Cytoplasm Expressed in adipocytes. GTPase activator activity protein binding cytoplasm cytosol intracellular protein transport membrane Rab GTPase binding activation of GTPase activity uc008jbj.1 uc008jbj.2 uc008jbj.3 
ENSMUST00000044564.15 Foxj3 ENSMUST00000044564.15 forkhead box J3, transcript variant 1 (from RefSeq NM_172699.3) A2AA37 A2AA38 ENSMUST00000044564.1 ENSMUST00000044564.10 ENSMUST00000044564.11 ENSMUST00000044564.12 ENSMUST00000044564.13 ENSMUST00000044564.14 ENSMUST00000044564.2 ENSMUST00000044564.3 ENSMUST00000044564.4 ENSMUST00000044564.5 ENSMUST00000044564.6 ENSMUST00000044564.7 ENSMUST00000044564.8 ENSMUST00000044564.9 FOXJ3_MOUSE Kiaa1041 NM_172699 Q3UTD8 Q8BUR3 uc008umt.1 uc008umt.2 uc008umt.3 Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (PubMed:19914232). Plays an important role in spermatogenesis (PubMed:27739607). Required for the survival of spermatogonia and participates in spermatocyte meiosis (PubMed:27739607). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BUR3-1; Sequence=Displayed; Name=2; IsoId=Q8BUR3-2; Sequence=VSP_010368; Highly expressed in spermatogonia, spermatocytes, and round spermatids within the testis (at protein level). Accumulates in the testis starting at postnatal day 3, and remains at a steady level from 1 to 3 weeks in age. Increased markedly during skeletal muscle differentiation (at protein level). Null mice have an abnormal skeletal muscle fiber type ratio in males as well as defects in muscle regeneration following injury (PubMed:19914232). Male germ-cell-specific conditional knockout results in complete male infertility, early loss of spermatogonia and meiotic arrest in spermatocytes (PubMed:27739607). Spermatocytes show significantly reduced expression meiotic arrest-related genes (PubMed:27739607). Sequence=BAC98081.1; Type=Erroneous initiation; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc008umt.1 uc008umt.2 uc008umt.3 
ENSMUST00000044565.15 Col16a1 ENSMUST00000044565.15 collagen, type XVI, alpha 1, transcript variant 1 (from RefSeq NM_028266.6) A3KFV5 COGA1_MOUSE Col16a1 ENSMUST00000044565.1 ENSMUST00000044565.10 ENSMUST00000044565.11 ENSMUST00000044565.12 ENSMUST00000044565.13 ENSMUST00000044565.14 ENSMUST00000044565.2 ENSMUST00000044565.3 ENSMUST00000044565.4 ENSMUST00000044565.5 ENSMUST00000044565.6 ENSMUST00000044565.7 ENSMUST00000044565.8 ENSMUST00000044565.9 NM_028266 Q8BLX7 Q9CZS2 uc008uys.1 uc008uys.2 uc008uys.3 Involved in mediating cell attachment and inducing integrin- mediated cellular reactions, such as cell spreading and alterations in cell morphology. Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3 (By similarity). Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8BLX7-1; Sequence=Displayed; Name=2 ; IsoId=Q8BLX7-2; Sequence=VSP_052375; Expressed in most tissues examined with highest levels of expression observed in heart. Strongly expressed in cortical and medullar regions of kidney and more weakly expressed in lung. Also detected in the ciliary muscle of the eye, on the serosa layer lining the muscularis externa of intestinal tissue, and in the perimysium membrane lining both the cardiac muscle bundle and the smooth muscle tissue of the small intestine. Strongly stained in particulate or granular structures. Not detected in brain or skeletal muscle. At 8 dpc no significant expression of mRNA or protein is observed, but strong signals are observed in placental trophoblasts. By 11 dpc weak positive signals are observed in heart. During later stages of development, stronger expression is observed in a variety of tissues, particularly in the atrial and ventricular walls of the developing heart, spinal root neural fibers and skin. This sequence defines eighteen different domains, nine triple- helical domains (COL9 to COL1) and ten non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either elastic or flexible. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Glycosylated. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. morphogenesis of a branching structure integrin binding extracellular matrix structural constituent extracellular region collagen trimer extracellular space cell-cell junction cell adhesion cell-matrix adhesion heparin binding extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix integrin activation cell adhesion mediated by integrin positive regulation of focal adhesion assembly cellular response to amino acid stimulus cell-cell adhesion uc008uys.1 uc008uys.2 uc008uys.3 
ENSMUST00000044567.4 Alg5 ENSMUST00000044567.4 ALG5 dolichyl-phosphate beta-glucosyltransferase (from RefSeq NM_025442.3) ALG5_MOUSE ENSMUST00000044567.1 ENSMUST00000044567.2 ENSMUST00000044567.3 NM_025442 Q9DB25 uc008pft.1 uc008pft.2 Required for the assembly of lipid-linked oligosaccharides in kidney epithelial cells, and protein N-glycosylation. Required for polycystin-1 (PKD1) glycosylation and maturation. Reaction=a dolichyl phosphate + UDP-alpha-D-glucose = a dolichyl beta- D-glucosyl phosphate + UDP; Xref=Rhea:RHEA:15401, Rhea:RHEA- COMP:9517, Rhea:RHEA-COMP:9528, ChEBI:CHEBI:57525, ChEBI:CHEBI:57683, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.117; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 2 family. dolichyl-phosphate beta-glucosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation protein N-linked glycosylation determination of left/right symmetry membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups uc008pft.1 uc008pft.2 
ENSMUST00000044579.12 Crlf2 ENSMUST00000044579.12 cytokine receptor-like factor 2, transcript variant 8 (from RefSeq NR_189330.1) A0A0R4J0F5 A0A0R4J0F5_MOUSE Crlf2 ENSMUST00000044579.1 ENSMUST00000044579.10 ENSMUST00000044579.11 ENSMUST00000044579.2 ENSMUST00000044579.3 ENSMUST00000044579.4 ENSMUST00000044579.5 ENSMUST00000044579.6 ENSMUST00000044579.7 ENSMUST00000044579.8 ENSMUST00000044579.9 NR_189330 uc008ypg.1 uc008ypg.2 uc008ypg.3 uc008ypg.4 Belongs to the type I cytokine receptor family. Type 5 subfamily. uc008ypg.1 uc008ypg.2 uc008ypg.3 uc008ypg.4 
ENSMUST00000044581.14 1700025G04Rik ENSMUST00000044581.14 RIKEN cDNA 1700025G04 gene (from RefSeq NM_197990.3) CA021_MOUSE ENSMUST00000044581.1 ENSMUST00000044581.10 ENSMUST00000044581.11 ENSMUST00000044581.12 ENSMUST00000044581.13 ENSMUST00000044581.2 ENSMUST00000044581.3 ENSMUST00000044581.4 ENSMUST00000044581.5 ENSMUST00000044581.6 ENSMUST00000044581.7 ENSMUST00000044581.8 ENSMUST00000044581.9 NM_197990 Q8K207 uc007cze.1 uc007cze.2 uc007cze.3 uc007cze.4 molecular_function cellular_component biological_process uc007cze.1 uc007cze.2 uc007cze.3 uc007cze.4 
ENSMUST00000044583.10 Vmn2r65 ENSMUST00000044583.10 vomeronasal 2, receptor 65 (from RefSeq NM_001105180.1) ENSMUST00000044583.1 ENSMUST00000044583.2 ENSMUST00000044583.3 ENSMUST00000044583.4 ENSMUST00000044583.5 ENSMUST00000044583.6 ENSMUST00000044583.7 ENSMUST00000044583.8 ENSMUST00000044583.9 G3X931 G3X931_MOUSE NM_001105180 Vmn2r65 uc012fog.1 uc012fog.2 uc012fog.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane neuron differentiation G-protein coupled olfactory receptor activity signaling receptor activity detection of chemical stimulus involved in sensory perception of smell uc012fog.1 uc012fog.2 uc012fog.3 
ENSMUST00000044584.6 Lgals2 ENSMUST00000044584.6 lectin, galactose-binding, soluble 2 (from RefSeq NM_025622.3) ENSMUST00000044584.1 ENSMUST00000044584.2 ENSMUST00000044584.3 ENSMUST00000044584.4 ENSMUST00000044584.5 LEG2_MOUSE NM_025622 Q9CQW5 Q9D800 Q9D862 uc007wrm.1 uc007wrm.2 uc007wrm.3 This protein binds beta-galactoside. Its physiological function is not yet known. Homodimer. galactoside binding carbohydrate binding uc007wrm.1 uc007wrm.2 uc007wrm.3 
ENSMUST00000044598.14 Rpgr ENSMUST00000044598.14 retinitis pigmentosa GTPase regulator, transcript variant 1 (from RefSeq NM_001177950.1) A2ADP3 ENSMUST00000044598.1 ENSMUST00000044598.10 ENSMUST00000044598.11 ENSMUST00000044598.12 ENSMUST00000044598.13 ENSMUST00000044598.2 ENSMUST00000044598.3 ENSMUST00000044598.4 ENSMUST00000044598.5 ENSMUST00000044598.6 ENSMUST00000044598.7 ENSMUST00000044598.8 ENSMUST00000044598.9 G9BBQ2 NM_001177950 O88408 Q9CU92 Q9R0X5 RPGR_MOUSE uc009sqh.1 uc009sqh.2 uc009sqh.3 uc009sqh.4 uc009sqh.5 Could be a guanine-nucleotide releasing factor (By similarity). Plays a role in ciliogenesis (By similarity). Probably regulates cilia formation by regulating actin stress filaments and cell contractility (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia (By similarity). Plays an important role in photoreceptor integrity. Isoform 5 may play a critical role in spermatogenesis and in intraflagellar transport processes. Interacts with SPATA7 (PubMed:29899041). Interacts with PDE6D (PubMed:9990021). Interacts with RPGRIP1 and RPGRIP1L; PDE6D, RPGRIP1 and RPGRIP1L may compete for the same binding sites (By similarity). Interacts with NPM1 (By similarity). Interacts with PDE6D. Isoform 5 interacts (via N-terminus) with SMC1A and SMC3 (PubMed:16043481). Isoform 5 interacts with CEP290 (PubMed:16632484). Interacts with WHRN (PubMed:22323458). Q9R0X5; Q68CZ1: RPGRIP1L; Xeno; NbExp=3; IntAct=EBI-6915619, EBI-5235485; Q9R0X5-5; Q80VW5-12: Whrn; NbExp=2; IntAct=EBI-6915646, EBI-6915655; Golgi apparatus toplasm, cytoskeleton, microtubule organizing center, centrosome Cell projection, cilium Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium (PubMed:29899041). Colocalizes with WHRN in the photoreceptor connecting cilium (PubMed:22323458). Colocalizes with CEP290 in the photoreceptor connecting cilium (PubMed:16632484). Colocalizes with RPGRIP1 in the photoreceptor connecting cilium (PubMed:15772089). [Isoform 5]: Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=ex1-19; IsoId=Q9R0X5-1; Sequence=Displayed; Name=2; IsoId=Q9R0X5-2; Sequence=VSP_005552; Name=3; IsoId=Q9R0X5-3; Sequence=VSP_005552, VSP_005553; Name=4; IsoId=Q9R0X5-4; Sequence=VSP_005551, VSP_005552, VSP_005554, VSP_005555; Name=5; Synonyms=ORF15; IsoId=Q9R0X5-5; Sequence=VSP_045292; Expressed in the retina (at protein level) (PubMed:10401007, PubMed:22323458, PubMed:12140192, PubMed:16632484, PubMed:20007830, PubMed:21546531, PubMed:29899041). Isoforms 1: Expressed in the retina (at protein level) (PubMed:21546531). Isoform 5: Expressed in the retina (at protein level) (PubMed:20007830, PubMed:21546531). Expressed in the brain (PubMed:9677393, PubMed:10401007). Expressed in the testis (at protein level) (PubMed:10401007, PubMed:18579752). Expressed in kidney (at protein level) (PubMed:10401007, PubMed:20805823). At postnatal day 3 isoform 1 is expressed in the retina in a narrow band at the developing photoreceptor layer; expression in this band persists through to postnatal day 14 but becomes severely diminished in the adult retina. Isoform 5 is first detected in the retina at postnatal day 14 and is expressed at increased levels in the adult retina (at protein level). Expressed throughout embryonic development from day 7 of gestation. Also expressed in adult. The RCC1 repeat region mediates interactions with RPGRIP1. Prenylated. Male transgenic mice carrying multiple copies of the Rpgr transgene are infertile showing normal mating but no progeny; these mice also exhibit reduced sperm numbers as well as morphological and functional defects in the sperm flagellum. Male BL/6 and BALB/c transgenic mice with an in-frame deletion of exon 4 of Rpgr show retinal degeneration that is rod or cone dominated, respectively. Overexpression of isoform 1 results in atypical accumulation of Rpgr in photoreceptor outer segments, abnormal photoreceptor morphology and severe retinal degeneration. In a mouse model of X-linked retinosa pigmentosa, where a 32bp duplication leads to a frameshift in the reading frame and a premature stop codon in isoform 5 (ORF15), mice exhibited retinal pathology including pigment loss and a slow progressive decrease in outer nuclear layer thickness. Sequence=AAC40190.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB30628.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAM22657.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; photoreceptor outer segment guanyl-nucleotide exchange factor activity protein binding cytoplasm Golgi apparatus centrosome microtubule organizing center cytoskeleton cilium visual perception cell projection organization motile cilium photoreceptor connecting cilium ciliary basal body sperm flagellum intraciliary transport eye photoreceptor cell development cell projection response to stimulus retina morphogenesis in camera-type eye cilium assembly cellular response to light stimulus uc009sqh.1 uc009sqh.2 uc009sqh.3 uc009sqh.4 uc009sqh.5 
ENSMUST00000044602.8 Ces1g ENSMUST00000044602.8 carboxylesterase 1G (from RefSeq NM_021456.4) Ces1 ENSMUST00000044602.1 ENSMUST00000044602.2 ENSMUST00000044602.3 ENSMUST00000044602.4 ENSMUST00000044602.5 ENSMUST00000044602.6 ENSMUST00000044602.7 EST1_MOUSE NM_021456 O55136 Q8VCC2 uc009muq.1 uc009muq.2 uc009muq.3 uc009muq.4 This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with Ces7 and Ces3 on chromosome 8. [provided by RefSeq, Jun 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK136588.1, Y12887.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process. First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein- delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile. Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence=; Reaction=cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+); Xref=Rhea:RHEA:33875, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30823, ChEBI:CHEBI:46898; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33876; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26133; Evidence=; Reaction=H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2; Xref=Rhea:RHEA:48296, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:90230, ChEBI:CHEBI:606564; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48297; Evidence=; Reaction=a cholesterol ester + H2O = a fatty acid + cholesterol + H(+); Xref=Rhea:RHEA:36403, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:17002, ChEBI:CHEBI:28868; EC=3.1.1.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36404; Evidence=; Reaction=H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha; Xref=Rhea:RHEA:48300, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:57404, ChEBI:CHEBI:90233; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48301; Evidence=; Homotrimer and homohexamer. Binds to beta-glucuronidase (By similarity). Endoplasmic reticulum lumen Cytoplasm Lipid droplet Note=Moves from cytoplasm to lipid droplets upon lipid loading. Associates with lipid droplets independently of triglycerides (TG) content of the droplets and hydrolyzes cholesteryl esters more efficiently from mixed droplets. Detected in kidney, liver and lung. Up-regulated in liver upon feeding a diet enriched in cholestyramine or cholate. Belongs to the type-B carboxylesterase/lipase family. sterol esterase activity triglyceride lipase activity extracellular space endoplasmic reticulum endoplasmic reticulum lumen response to bacterium regulation of gene expression lipid catabolic process hydrolase activity chylomicron assembly carboxylic ester hydrolase activity methyl indole-3-acetate esterase activity regulation of triglyceride metabolic process regulation of chylomicron remnant clearance uc009muq.1 uc009muq.2 uc009muq.3 uc009muq.4 
ENSMUST00000044604.16 Crybg3 ENSMUST00000044604.16 Belongs to the beta/gamma-crystallin family. (from UniProt A0A384DV78) A0A384DV78 A0A384DV78_MOUSE BC043118 Crybg3 ENSMUST00000044604.1 ENSMUST00000044604.10 ENSMUST00000044604.11 ENSMUST00000044604.12 ENSMUST00000044604.13 ENSMUST00000044604.14 ENSMUST00000044604.15 ENSMUST00000044604.2 ENSMUST00000044604.3 ENSMUST00000044604.4 ENSMUST00000044604.5 ENSMUST00000044604.6 ENSMUST00000044604.7 ENSMUST00000044604.8 ENSMUST00000044604.9 uc007zpk.1 uc007zpk.2 uc007zpk.3 Belongs to the beta/gamma-crystallin family. uc007zpk.1 uc007zpk.2 uc007zpk.3 
ENSMUST00000044616.10 Ints8 ENSMUST00000044616.10 integrator complex subunit 8, transcript variant 2 (from RefSeq NM_178112.5) A2API4 ENSMUST00000044616.1 ENSMUST00000044616.2 ENSMUST00000044616.3 ENSMUST00000044616.4 ENSMUST00000044616.5 ENSMUST00000044616.6 ENSMUST00000044616.7 ENSMUST00000044616.8 ENSMUST00000044616.9 INT8_MOUSE NM_178112 Q3TEM3 Q3TNW0 Q6PFD3 Q80V86 Q810I3 Q8BQJ8 Q8BT91 uc008rzg.1 uc008rzg.2 uc008rzg.3 uc008rzg.4 Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Nucleus Highly expressed in the brain at 14.5 dpc especially in the cortex ventricular zone and hindbrain. Belongs to the Integrator subunit 8 family. Sequence=AAH50192.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH57618.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC25374.2; Type=Frameshift; Evidence=; molecular_function nucleus snRNA processing integrator complex snRNA 3'-end processing uc008rzg.1 uc008rzg.2 uc008rzg.3 uc008rzg.4 
ENSMUST00000044620.11 Brca2 ENSMUST00000044620.11 breast cancer 2, early onset, transcript variant 1 (from RefSeq NM_001081001.2) BRCA2_MOUSE Brca2 ENSMUST00000044620.1 ENSMUST00000044620.10 ENSMUST00000044620.2 ENSMUST00000044620.3 ENSMUST00000044620.4 ENSMUST00000044620.5 ENSMUST00000044620.6 ENSMUST00000044620.7 ENSMUST00000044620.8 ENSMUST00000044620.9 F8VPU5 Fancd1 NM_001081001 O35922 P97383 P97929 uc009aua.1 uc009aua.2 uc009aua.3 uc009aua.4 uc009aua.5 Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination (By similarity). Monomer and dimer. Interacts with RAD51; regulates RAD51 recruitment and function at sites of DNA repair. Interacts with SEM1, WDR16, USP11, DMC1, ROCK2 and NPM1. Interacts with both nonubiquitinated and monoubiquitinated FANCD2; this complex also includes XRCC3 and phosphorylated FANCG. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Component of the homologous recombination repair (HR) complex composed of ERCC5/XPG, BRCA2, PALB2, DSS1 and RAD51 (By similarity). Within the complex, interacts with ERCC5/XPG and PALB2 (By similarity). Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with BRCA1 only in the presence of PALB2 which serves as the bridging protein. Interacts with POLH; the interaction is direct. Interacts with the TREX-2 complex subunits PCID2 and SEM1 (By similarity). Interacts with HSF2BP and BRME1; the interaction with HSF2BP is direct and allows the formation of a ternary complex (PubMed:32345962, PubMed:32460033, PubMed:31242413, PubMed:30760716, PubMed:32845237). The complex BRME1:HSF2BP:BRCA2 interacts with SPATA22, MEIOB and RAD51 (PubMed:32345962, PubMed:30760716). Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Widely expressed. Highest expression in cerebellum, testis, ileum, appendix, epididymis, ovary and mammary gland. No expression in lung. In the mammary gland, expression increases dramatically during pregnancy. Phosphorylated by ATM upon irradiation-induced DNA damage. Phosphorylation by CHEK1 and CHEK2 regulates interaction with RAD51. Phosphorylation at Ser-3291 by CDK1 and CDK2 is low in S phase when recombination is active, but increases as cells progress towards mitosis; this phosphorylation prevents homologous recombination- dependent repair during S phase and G2 by inhibiting RAD51 binding. Ubiquitinated in the absence of DNA damage; this does not lead to proteasomal degradation. In contrast, ubiquitination in response to DNA damage leads to proteasomal degradation. mitotic cytokinesis telomere maintenance via recombination double-strand break repair via homologous recombination nuclear chromosome, telomeric region lateral element oocyte maturation inner cell mass cell proliferation protease binding DNA binding single-stranded DNA binding protein binding nucleus nucleoplasm cytoplasm centrosome microtubule organizing center cytosol cytoskeleton DNA repair nucleotide-excision repair double-strand break repair DNA recombination cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cell cycle male meiosis I spermatogenesis brain development cell aging protein C-terminus binding cell proliferation female gonad development intrinsic apoptotic signaling pathway in response to DNA damage response to X-ray response to UV-C response to gamma radiation H3 histone acetyltransferase activity H4 histone acetyltransferase activity hemopoiesis secretory granule mammary gland development homologous chromosome orientation involved in meiotic metaphase I plate congression regulation of cytokinesis macromolecular complex BRCA2-MAGE-D1 complex negative regulation of mammary gland epithelial cell proliferation multicellular organism growth intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator identical protein binding chordate embryonic development gamma-tubulin binding histone H3 acetylation histone H4 acetylation positive regulation of transcription, DNA-templated positive regulation of mitotic cell cycle replication fork protection chromosome organization centrosome duplication establishment of protein localization to telomere mitotic recombination-dependent replication fork processing uc009aua.1 uc009aua.2 uc009aua.3 uc009aua.4 uc009aua.5 
ENSMUST00000044622.7 Epg5 ENSMUST00000044622.7 ectopic P-granules 5 autophagy tethering factor (from RefSeq NM_001195633.2) ENSMUST00000044622.1 ENSMUST00000044622.2 ENSMUST00000044622.3 ENSMUST00000044622.4 ENSMUST00000044622.5 ENSMUST00000044622.6 EPG5_MOUSE Kiaa1632 NM_001195633 Q80TA9 uc008fsa.1 uc008fsa.2 uc008fsa.3 uc008fsa.4 Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located. Interacts with RAN. Cytoplasm, perinuclear region Lysosome Belongs to the EPG5 family. molecular_function cytoplasm lysosome nucleotide transport autophagy endosome to lysosome transport endocytic recycling toll-like receptor 9 signaling pathway perinuclear region of cytoplasm autophagosome maturation cellular response to dsDNA uc008fsa.1 uc008fsa.2 uc008fsa.3 uc008fsa.4 
ENSMUST00000044624.8 Kcnk9 ENSMUST00000044624.8 potassium channel, subfamily K, member 9 (from RefSeq NM_001033876.2) B2RT82 ENSMUST00000044624.1 ENSMUST00000044624.2 ENSMUST00000044624.3 ENSMUST00000044624.4 ENSMUST00000044624.5 ENSMUST00000044624.6 ENSMUST00000044624.7 KCNK9_MOUSE NM_001033876 Q3LS21 Task3 uc007wbk.1 uc007wbk.2 uc007wbk.3 pH-dependent, voltage-insensitive, background potassium channel protein. Homodimer. Heterodimer with KCNK1. Cell membrane ; Multi-pass membrane protein Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. voltage-gated potassium channel activity potassium channel activity plasma membrane integral component of plasma membrane ion transport potassium ion transport synaptic vesicle membrane integral component of membrane potassium ion leak channel activity stabilization of membrane potential potassium ion transmembrane transport potassium ion import across plasma membrane uc007wbk.1 uc007wbk.2 uc007wbk.3 
ENSMUST00000044634.12 Slc25a21 ENSMUST00000044634.12 solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21, transcript variant 1 (from RefSeq NM_172577.3) ENSMUST00000044634.1 ENSMUST00000044634.10 ENSMUST00000044634.11 ENSMUST00000044634.2 ENSMUST00000044634.3 ENSMUST00000044634.4 ENSMUST00000044634.5 ENSMUST00000044634.6 ENSMUST00000044634.7 ENSMUST00000044634.8 ENSMUST00000044634.9 NM_172577 ODC_MOUSE Odc Q8BY72 Q8BZ09 uc007npj.1 uc007npj.2 uc007npj.3 Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2- oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2- oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle. Reaction=2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in); Xref=Rhea:RHEA:71739, ChEBI:CHEBI:16810, ChEBI:CHEBI:57499; Evidence=; Reaction=2-oxoglutarate(out) + hexanedioate(in) = 2-oxoglutarate(in) + hexanedioate(out); Xref=Rhea:RHEA:71743, ChEBI:CHEBI:16810, ChEBI:CHEBI:17128; Evidence=; Reaction=2-oxoglutarate(out) + L-2-aminoadipate(in) = 2- oxoglutarate(in) + L-2-aminoadipate(out); Xref=Rhea:RHEA:71747, ChEBI:CHEBI:16810, ChEBI:CHEBI:58672; Evidence=; Reaction=2-oxoglutarate(out) + glutarate(in) = 2-oxoglutarate(in) + glutarate(out); Xref=Rhea:RHEA:71751, ChEBI:CHEBI:16810, ChEBI:CHEBI:30921; Evidence=; Reaction=2-oxoglutarate(out) + 2-oxoheptanedioate(in) = 2- oxoglutarate(in) + 2-oxoheptanedioate(out); Xref=Rhea:RHEA:71755, ChEBI:CHEBI:16810, ChEBI:CHEBI:72701; Evidence=; Reaction=2-oxoglutarate(out) + heptanedioate(in) = 2-oxoglutarate(in) + heptanedioate(out); Xref=Rhea:RHEA:71759, ChEBI:CHEBI:16810, ChEBI:CHEBI:36165; Evidence=; Reaction=2-oxoglutarate(out) + citrate(in) = 2-oxoglutarate(in) + citrate(out); Xref=Rhea:RHEA:71763, ChEBI:CHEBI:16810, ChEBI:CHEBI:16947; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. mitochondrion mitochondrial inner membrane membrane integral component of membrane uc007npj.1 uc007npj.2 uc007npj.3 
ENSMUST00000044642.14 Micall2 ENSMUST00000044642.14 MICAL-like 2 (from RefSeq NM_174850.3) ENSMUST00000044642.1 ENSMUST00000044642.10 ENSMUST00000044642.11 ENSMUST00000044642.12 ENSMUST00000044642.13 ENSMUST00000044642.2 ENSMUST00000044642.3 ENSMUST00000044642.4 ENSMUST00000044642.5 ENSMUST00000044642.6 ENSMUST00000044642.7 ENSMUST00000044642.8 ENSMUST00000044642.9 Jrab MILK2_MOUSE NM_174850 Q3TN34 Q3TPY3 Q3UB65 uc009agx.1 uc009agx.2 uc009agx.3 uc009agx.4 Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth. Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly. Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling. Interacts with RAB8B. Interacts (preferentially in opened conformation) with ACTN1 and ACTN4; stimulated by RAB13 activation. Interacts (via calponin-homology (CH) domain) with the filamins FLNA, FLNB and FLNC (via actin-binding domain). Q3TN34; P57780: Actn4; NbExp=9; IntAct=EBI-1779852, EBI-445071; Q3TN34; P51153: RAB13; Xeno; NbExp=8; IntAct=EBI-1779852, EBI-1780121; Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Recycling endosome. Cell projection Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Detected in brain, lung, liver and kidney (at protein level). Probably exists in a closed and an open conformation due to interaction of the C-terminal coiled-coil domain with an N-terminal region including the calponin-homology (CH) and the LIM zinc-binding domain. The conformational change is regulated by RAB13. protein binding cytoplasm endosome microtubule organizing center cytosol cytoskeleton plasma membrane cell-cell junction bicellular tight junction membrane Rab GTPase binding actin cytoskeleton organization actin filament polymerization cell junction filamin binding neuron projection development actin cytoskeleton reorganization filamentous actin endocytic recycling substrate adhesion-dependent cell spreading actinin binding cell projection neuron projection metal ion binding actin filament binding recycling endosome bicellular tight junction assembly stress fiber actin filament bundle uc009agx.1 uc009agx.2 uc009agx.3 uc009agx.4 
ENSMUST00000044660.6 Armc5 ENSMUST00000044660.6 armadillo repeat containing 5 (from RefSeq NM_146205.2) ARMC5_MOUSE Armc5 ENSMUST00000044660.1 ENSMUST00000044660.2 ENSMUST00000044660.3 ENSMUST00000044660.4 ENSMUST00000044660.5 NM_146205 Q5EBP3 Q6KAU6 Q8CDI5 Q8R3J0 uc009jyk.1 uc009jyk.2 Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:28169274). Negatively regulates adrenal cells survival. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (By similarity). Cytoplasm Expression is high in the thymus, stomach, bone marrow and lymphatic tissues (including lymph nodes and intestinal wall). Also expressed in the adrenal gland, skin and in brain structures, with noticeable levels found in the cerebellum. In CD4(+) T-cells, mRNA expression is induced 2h after CD3E plus CD28 stimulation, then subsides and remains low between 24 and 72h post-activation. Embryonic lethality, with its severity depending on genetic background of the mice: embryonic lethality becomes more severe with higher degrees of genetic background purity (PubMed:28169274). Knockout mice are small in body size. They have compromised T-cell proliferation and differentiation into Th1 and Th17 cells, increased T-cell apoptosis, reduced severity of experimental autoimmune encephalitis, and defective immune responses to lymphocytic choriomeningitis virus infection. They develop adrenal gland hyperplasia in old age (PubMed:28169274). Sequence=BAC26726.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAD21361.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleoplasm cytoplasm cytosol focal adhesion biological_process uc009jyk.1 uc009jyk.2 
ENSMUST00000044672.11 Cdk19 ENSMUST00000044672.11 cyclin dependent kinase 19, transcript variant 4 (from RefSeq NM_001291817.1) CDK19_MOUSE Cdc2l6 ENSMUST00000044672.1 ENSMUST00000044672.10 ENSMUST00000044672.2 ENSMUST00000044672.3 ENSMUST00000044672.4 ENSMUST00000044672.5 ENSMUST00000044672.6 ENSMUST00000044672.7 ENSMUST00000044672.8 ENSMUST00000044672.9 Kiaa1028 NM_001291817 Q80TM1 Q8BWD8 uc007eww.1 uc007eww.2 uc007eww.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Cytoplasm Cytoplasm, perinuclear region Nucleus Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Sequence=BAC65703.1; Type=Erroneous initiation; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus cytosol protein phosphorylation RNA polymerase II carboxy-terminal domain kinase activity kinase activity phosphorylation mediator complex transferase activity positive regulation of apoptotic process positive regulation of inflammatory response regulation of cell cycle cellular response to lipopolysaccharide uc007eww.1 uc007eww.2 uc007eww.3 
ENSMUST00000044673.9 Trmt10b ENSMUST00000044673.9 tRNA methyltransferase 10B, transcript variant 7 (from RefSeq NR_185033.1) A2AKB5 A2AKB6 ENSMUST00000044673.1 ENSMUST00000044673.2 ENSMUST00000044673.3 ENSMUST00000044673.4 ENSMUST00000044673.5 ENSMUST00000044673.6 ENSMUST00000044673.7 ENSMUST00000044673.8 NR_185033 Q8VCR1 Q9D075 Rg9mtd3 TM10B_MOUSE uc008ssj.1 uc008ssj.2 uc008ssj.3 S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs. Reaction=guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)- methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43156, Rhea:RHEA-COMP:10367, Rhea:RHEA-COMP:10368, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.221; Evidence=; Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family. Sequence=CAM26862.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM26863.1; Type=Erroneous gene model prediction; Evidence=; tRNA binding nucleus nucleoplasm mitochondrion cytosol methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity transferase activity tRNA methylation methylation tRNA (guanine(9)-N(1))-methyltransferase activity mitochondrial tRNA processing uc008ssj.1 uc008ssj.2 uc008ssj.3 
ENSMUST00000044675.5 Jmjd7 ENSMUST00000044675.5 jumonji domain containing 7 (from RefSeq NM_001114637.1) A2AP62 ENSMUST00000044675.1 ENSMUST00000044675.2 ENSMUST00000044675.3 ENSMUST00000044675.4 JMJD7_MOUSE Jmjd7 NM_001114637 P0C872 Q4QQM1 Q80VV8 Q91W88 uc008luy.1 uc008luy.2 uc008luy.3 uc008luy.4 Bifunctional enzyme that acts both as an endopeptidase and 2- oxoglutarate-dependent monooxygenase (PubMed:28847961) (By similarity). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961). Additionally, may play a role in protein biosynthesis by modifying the translation machinery. Acts as a Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys- 21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (By similarity). Reaction=2-oxoglutarate + L-lysyl-[protein] + O2 = (3S)-3-hydroxy-L- lysyl-[protein] + CO2 + succinate; Xref=Rhea:RHEA:57152, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:15133, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:141492; EC=1.14.11.63; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Homodimer; disulfide-linked. Interacts with DRG1 and DRG2. Nucleus Cytoplasm This sequence was first thought to be an alternatively spliced isoform of Pla2g4b. It is derived from Jmjd7 which is located upstream of Pla2g4b. Most tissues also express read-through transcripts from Jmjd7 into the downstream Pla2g4b gene, some of which may encode fusion proteins combining the N-terminus of this protein with PLA2G4B protein. endopeptidase activity aminopeptidase activity monooxygenase activity nucleus cytoplasm proteolysis peptidase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors hydrolase activity protein hydroxylation methylated histone binding metal ion binding oxidation-reduction process uc008luy.1 uc008luy.2 uc008luy.3 uc008luy.4 
ENSMUST00000044681.7 Arl6ip5 ENSMUST00000044681.7 ADP-ribosylation factor-like 6 interacting protein 5 (from RefSeq NM_022992.2) Aip5 ENSMUST00000044681.1 ENSMUST00000044681.2 ENSMUST00000044681.3 ENSMUST00000044681.4 ENSMUST00000044681.5 ENSMUST00000044681.6 Jwa NM_022992 PRAF3_MOUSE Pra2 Praf3 Q8C2Q1 Q8R5J9 Q9D838 Q9DB37 Q9WUG9 uc009dar.1 uc009dar.2 uc009dar.3 Regulates intracellular concentrations of taurine and glutamate (By similarity). Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner (PubMed:12119102, PubMed:18684713). Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum (By similarity). Homodimer. Heterodimer with ARL6IP1 (PubMed:18684713). Forms multimers. Interacts with ARL6 (PubMed:10508919). Interacts with prenylated RAB1A and RAB3A. Interacts with SLC1A1/EAAC1 (PubMed:18684713, PubMed:12119102). Interacts with RTN2 (via first transmembrane domain) (By similarity). Does not interact with VAMP1, VAMP2 or VAMP3 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasm Cytoplasm, cytoskeleton Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules. Expressed in the cerebral cortex, cerebellum, hippocampus, olfactory bulbs, medulla oblongate and limbic system (at protein level) (PubMed:18684713). Ubiquitous. By methyl-beta-cyclodextrin. Up-regulated upon chronic morphine injection, in amygdala only, other brain regions remain unaffected. Induction by morphine may affect glutamate uptake in the amygdala, causing mice to develop morphine tolerance and dependence (PubMed:12438930). Was originally reported to be induced by retinoic acid (PubMed:12562531). Belongs to the PRA1 family. Sequence=AAD33050.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; Sequence=AAD33050.1; Type=Frameshift; Evidence=; negative regulation of L-glutamate transport protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytoskeleton plasma membrane protein C-terminus binding intrinsic apoptotic signaling pathway in response to oxidative stress negative regulation of mitochondrial membrane potential L-glutamate transport membrane integral component of membrane positive regulation of stress-activated MAPK cascade positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of transport regulation of neurotransmitter uptake uc009dar.1 uc009dar.2 uc009dar.3 
ENSMUST00000044683.12 Nlrp5-ps ENSMUST00000044683.12 NLR family, pyrin domain containing 5, pseudogene, transcript variant 2 (from RefSeq NR_045120.1) ENSMUST00000044683.1 ENSMUST00000044683.10 ENSMUST00000044683.11 ENSMUST00000044683.2 ENSMUST00000044683.3 ENSMUST00000044683.4 ENSMUST00000044683.5 ENSMUST00000044683.6 ENSMUST00000044683.7 ENSMUST00000044683.8 ENSMUST00000044683.9 NR_045120 uc012ezw.1 uc012ezw.2 uc012ezw.3 uc012ezw.4 uc012ezw.5 uc012ezw.6 uc012ezw.1 uc012ezw.2 uc012ezw.3 uc012ezw.4 uc012ezw.5 uc012ezw.6 
ENSMUST00000044684.14 Helq ENSMUST00000044684.14 helicase, POLQ-like, transcript variant 4 (from RefSeq NM_001417988.1) ENSMUST00000044684.1 ENSMUST00000044684.10 ENSMUST00000044684.11 ENSMUST00000044684.12 ENSMUST00000044684.13 ENSMUST00000044684.2 ENSMUST00000044684.3 ENSMUST00000044684.4 ENSMUST00000044684.5 ENSMUST00000044684.6 ENSMUST00000044684.7 ENSMUST00000044684.8 ENSMUST00000044684.9 HELQ_MOUSE Hel308 Helq NM_001417988 Q2VPA6 Q2VPA7 Q640L4 Q8BWI5 Q8R4K9 uc008yhz.1 uc008yhz.2 uc008yhz.3 Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair (PubMed:24005329, PubMed:24005041). Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single- strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (By similarity). Possesses both DNA unwinding and annealing activities (By similarity). Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA (By similarity). Efficiently unwinds substrates containing 3' overhangs or a D-loop (By similarity). In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing (By similarity). Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Hexamer (By similarity). Interacts with POLN (By similarity). Interacts with RAD51B (By similarity). Interacts with RAD51C; promoting association with the BCDX2 complex (PubMed:24005329). Interacts with the replication protein A (RPA/RP-A) complex (By similarity). Interacts with RAD51; stimulating HELQ DNA helicase activity and ability to unwing DNA (By similarity). Nucleus Chromosome Note=Localizes to sites of DNA damage; localizes to damaged replication forks. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q2VPA6-1; Sequence=Displayed; Name=2; IsoId=Q2VPA6-2; Sequence=VSP_032952; Name=3; IsoId=Q2VPA6-3; Sequence=VSP_032949, VSP_032950, VSP_032951; Mice display Fanconi anemia-like phenotypes, characterized by subfertility, germ cell attrition, interstrand cross- links (ICLs) sensitivity and cancer susceptibility. Belongs to the helicase family. SKI2 subfamily. nucleotide binding double-strand break repair via homologous recombination nucleic acid binding DNA binding DNA helicase activity helicase activity ATP binding DNA metabolic process DNA repair cellular response to DNA damage stimulus hydrolase activity single-stranded DNA-dependent ATP-dependent DNA helicase activity single-stranded DNA-dependent ATP-dependent DNA helicase complex maturation of SSU-rRNA DNA duplex unwinding uc008yhz.1 uc008yhz.2 uc008yhz.3 
ENSMUST00000044687.7 Ifi27l2b ENSMUST00000044687.7 interferon, alpha-inducible protein 27 like 2B (from RefSeq NM_145449.2) ENSMUST00000044687.1 ENSMUST00000044687.2 ENSMUST00000044687.3 ENSMUST00000044687.4 ENSMUST00000044687.5 ENSMUST00000044687.6 IF27B_MOUSE Ifi27l2b Isg12(b2) NM_145449 Q6IEB6 Q8VC49 uc007ovv.1 uc007ovv.2 Functions in the intrinsic apoptotic signaling pathway and may have an interferon-induced antiviral activity. Homooligomer (PubMed:21151029). Interacts with BAK1 (PubMed:21151029). Interacts with BAX (PubMed:21151029). Interacts with adenine nucleotide translocase (PubMed:21151029). Mitochondrion inner membrane ; Multi-pass membrane protein Up-regulated by type-I interferon (PubMed:21151029). Up- regulated by poly(I:C) (PubMed:21151029). Belongs to the IFI6/IFI27 family. immune system process mitochondrion mitochondrial inner membrane apoptotic process membrane integral component of membrane identical protein binding innate immune response defense response to virus intrinsic apoptotic signaling pathway uc007ovv.1 uc007ovv.2 
ENSMUST00000044691.9 Bag2 ENSMUST00000044691.9 BCL2-associated athanogene 2 (from RefSeq NM_145392.2) BAG2_MOUSE ENSMUST00000044691.1 ENSMUST00000044691.2 ENSMUST00000044691.3 ENSMUST00000044691.4 ENSMUST00000044691.5 ENSMUST00000044691.6 ENSMUST00000044691.7 ENSMUST00000044691.8 NM_145392 Q3UMR7 Q91YN9 uc007any.1 uc007any.2 uc007any.3 Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Binds to the ATPase domain of HSP/HSC70 chaperones. May interact with NWD1. Interacts with HSPA1A (via NBD), HSPA1B (via NBD) and HSPA8. May interact with DNJC9; the interaction seems to be histone-dependent (By similarity). adenyl-nucleotide exchange factor activity positive regulation of protein processing protein metabolic process axon dendrite heat shock protein binding negative regulation of protein ubiquitination ubiquitin protein ligase binding negative regulation of protein binding identical protein binding ion channel binding tau protein binding protein stabilization chaperone binding positive regulation of proteasomal protein catabolic process negative regulation of ubiquitin protein ligase activity microtubule dendritic microtubule positive regulation of proteasomal ubiquitin-dependent protein catabolic process uc007any.1 uc007any.2 uc007any.3 
ENSMUST00000044694.8 Ttc36 ENSMUST00000044694.8 tetratricopeptide repeat domain 36 (from RefSeq NM_138951.1) ENSMUST00000044694.1 ENSMUST00000044694.2 ENSMUST00000044694.3 ENSMUST00000044694.4 ENSMUST00000044694.5 ENSMUST00000044694.6 ENSMUST00000044694.7 NM_138951 Q8VBW8 TTC36_MOUSE uc009peo.1 uc009peo.2 uc009peo.3 Belongs to the TTC36 family. molecular_function cellular_component cilium assembly uc009peo.1 uc009peo.2 uc009peo.3 
ENSMUST00000044705.12 Vstm2b ENSMUST00000044705.12 V-set and transmembrane domain containing 2B, transcript variant 5 (from RefSeq NM_001418635.1) ENSMUST00000044705.1 ENSMUST00000044705.10 ENSMUST00000044705.11 ENSMUST00000044705.2 ENSMUST00000044705.3 ENSMUST00000044705.4 ENSMUST00000044705.5 ENSMUST00000044705.6 ENSMUST00000044705.7 ENSMUST00000044705.8 ENSMUST00000044705.9 NM_001418635 Q8CEK5 Q9JME9 VTM2B_MOUSE uc291oug.1 uc291oug.2 Membrane ; Single-pass type I membrane protein molecular_function biological_process membrane integral component of membrane uc291oug.1 uc291oug.2 
ENSMUST00000044711.7 Snx22 ENSMUST00000044711.7 sorting nexin 22, transcript variant 3 (from RefSeq NM_001379336.1) ENSMUST00000044711.1 ENSMUST00000044711.2 ENSMUST00000044711.3 ENSMUST00000044711.4 ENSMUST00000044711.5 ENSMUST00000044711.6 NM_001379336 Ppib Q8C084 Q8C084_MOUSE Snx22 uc009qej.1 uc009qej.2 uc009qej.3 Membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the sorting nexin family. molecular_function cellular_component biological_process phosphatidylinositol binding uc009qej.1 uc009qej.2 uc009qej.3 
ENSMUST00000044721.13 Atp6v0a1 ENSMUST00000044721.13 ATPase, H+ transporting, lysosomal V0 subunit A1, transcript variant 1 (from RefSeq NM_016920.5) A2A5A1 Atp6n1 ENSMUST00000044721.1 ENSMUST00000044721.10 ENSMUST00000044721.11 ENSMUST00000044721.12 ENSMUST00000044721.2 ENSMUST00000044721.3 ENSMUST00000044721.4 ENSMUST00000044721.5 ENSMUST00000044721.6 ENSMUST00000044721.7 ENSMUST00000044721.8 ENSMUST00000044721.9 NM_016920 Q9JHJ4 Q9JL13 Q9JL14 Q9Z1G4 VPP1_MOUSE uc007lmu.1 uc007lmu.2 uc007lmu.3 uc007lmu.4 Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles. In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons (PubMed:33833240). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with SPAAR (PubMed:28024296). Q9Z1G4; P49769: Psen1; NbExp=2; IntAct=EBI-771149, EBI-990067; Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Melanosome Event=Alternative splicing; Named isoforms=3; Name=A1-II; IsoId=Q9Z1G4-1; Sequence=Displayed; Name=A1-I; IsoId=Q9Z1G4-2; Sequence=VSP_000342, VSP_000343; Name=A1-III; IsoId=Q9Z1G4-3; Sequence=VSP_000342; Predominantly expressed in neurons in the cortex and in the dentate gyrus, CA1 and CA3 regions of the hippocampus (at protein level) (PubMed:33833240). Expressed at lower levels in astrocytes, oligodendrocytes and microglia (at protein level) (PubMed:33833240). In the cerebellum, present in Purkinje and granule cells (at protein level) (PubMed:33833240). Embryonic lethal. Knockout embryos die at 5 to 6 dpc, before gastrulation. Belongs to the V-ATPase 116 kDa subunit family. vacuolar proton-transporting V-type ATPase, V0 domain protein binding cytoplasm Golgi apparatus cytosol plasma membrane ion transport vacuolar acidification synaptic vesicle hydrogen ion transmembrane transporter activity membrane integral component of membrane regulation of macroautophagy vacuolar proton-transporting V-type ATPase complex nuclear speck integral component of synaptic vesicle membrane cytoplasmic vesicle membrane cytoplasmic vesicle proton-transporting V-type ATPase, V0 domain melanosome intracellular organelle intracellular membrane-bounded organelle proton-transporting ATPase activity, rotational mechanism perinuclear region of cytoplasm ATPase binding toxin transport hydrogen ion transmembrane transport uc007lmu.1 uc007lmu.2 uc007lmu.3 uc007lmu.4 
ENSMUST00000044729.7 Itprid1 ENSMUST00000044729.7 ITPR interacting domain containing 1, transcript variant 1 (from RefSeq NM_001081665.2) Ccdc129 ENSMUST00000044729.1 ENSMUST00000044729.2 ENSMUST00000044729.3 ENSMUST00000044729.4 ENSMUST00000044729.5 ENSMUST00000044729.6 ITPI1_MOUSE NM_001081665 Q14B48 Q8BUH5 uc009cax.1 uc009cax.2 uc009cax.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14B48-1; Sequence=Displayed; Name=2; IsoId=Q14B48-2; Sequence=VSP_022256; Sequence=BAC39386.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function receptor binding cellular_component biological_process uc009cax.1 uc009cax.2 uc009cax.3 
ENSMUST00000044730.12 Mllt6 ENSMUST00000044730.12 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 (from RefSeq NM_139311.3) B1AR09 B1AR09_MOUSE ENSMUST00000044730.1 ENSMUST00000044730.10 ENSMUST00000044730.11 ENSMUST00000044730.2 ENSMUST00000044730.3 ENSMUST00000044730.4 ENSMUST00000044730.5 ENSMUST00000044730.6 ENSMUST00000044730.7 ENSMUST00000044730.8 ENSMUST00000044730.9 Mllt6 NM_139311 uc007lei.1 uc007lei.2 uc007lei.3 renal system process cellular_component excretion positive regulation of sodium ion transport nucleosome binding negative regulation of urine volume renal sodium excretion renal potassium excretion histone binding positive regulation of transcription from RNA polymerase II promoter metal ion binding negative regulation of histone H3-K79 methylation uc007lei.1 uc007lei.2 uc007lei.3 
ENSMUST00000044734.3 Rims4 ENSMUST00000044734.3 regulating synaptic membrane exocytosis 4, transcript variant 1 (from RefSeq NM_183023.2) ENSMUST00000044734.1 ENSMUST00000044734.2 NM_183023 P60191 RIMS4_MOUSE uc008nto.1 uc008nto.2 uc008nto.3 Regulates synaptic membrane exocytosis. Binds PPFIA3 (By similarity). Does not bind RAB3. Synapse neurotransmitter transport exocytosis membrane Rab GTPase binding cell junction regulation of membrane potential presynaptic membrane ion channel binding synapse regulation of synaptic plasticity cytoskeleton of presynaptic active zone calcium ion-regulated exocytosis of neurotransmitter positive regulation of synaptic transmission regulation of synapse organization synaptic membrane presynaptic active zone cytoplasmic component glutamatergic synapse regulation of synaptic vesicle exocytosis uc008nto.1 uc008nto.2 uc008nto.3 
ENSMUST00000044746.5 Mterf1a ENSMUST00000044746.5 mitochondrial transcription termination factor 1a, transcript variant 2 (from RefSeq NM_172135.2) ENSMUST00000044746.1 ENSMUST00000044746.2 ENSMUST00000044746.3 ENSMUST00000044746.4 MTF1A_MOUSE Mterf Mterf1 NM_172135 Q63ZX5 Q8C7T1 Q8CHZ9 uc008why.1 uc008why.2 Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand. Monomer. Mitochondrion Predominantly expressed in heart and liver, with extremely low levels in other tissues (PubMed:15582606). Expressed strongly in the heart and at lower levels in brain, liver and kidney (PubMed:23562081). Contains nine structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a left-handed superhelical assembly with a solenoid structure that wraps itself around DNA (By similarity). Phosphoprotein with mostly four phosphate groups. While the DNA- binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation (By similarity). Double knockout of Mterf1a and Mterf1b results in viable animals with no gross phenotype, and normal oxidative phosphorylation capacity. Steady-state mitochondrial DNA levels are normal. There are subtle effects on levels of mitochondrial transcripts: transcripts initiated at the light strand promoter and also downstream of the MTERF binding site are increased, levels of 7S RNA are reduced, while levels of other mitochondrial transcripts are normal. Belongs to the mTERF family. DNA binding double-stranded DNA binding protein binding mitochondrion cytosol DNA-templated transcription, termination regulation of transcription, DNA-templated termination of mitochondrial transcription DNA geometric change mitochondrial nucleoid uc008why.1 uc008why.2 
ENSMUST00000044752.6 Nrtn ENSMUST00000044752.6 neurturin (from RefSeq NM_008738.3) ENSMUST00000044752.1 ENSMUST00000044752.2 ENSMUST00000044752.3 ENSMUST00000044752.4 ENSMUST00000044752.5 NM_008738 NRTN_MOUSE P97463 uc008ddc.1 uc008ddc.2 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. Homozygous knockout mice for this gene exhibit defects in the development of the retina and enteric nervous system, and reduced cholinergic innervation of the heart and lacrimal glands. [provided by RefSeq, Aug 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK002508.1, BC057993.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Homodimer; disulfide-linked. Secreted. Widespread distribution. Belongs to the TGF-beta family. GDNF subfamily. neural crest cell migration extracellular region transmembrane receptor protein tyrosine kinase signaling pathway growth factor activity nerve development axon neuron projection development uc008ddc.1 uc008ddc.2 
ENSMUST00000044766.15 Dnaaf9 ENSMUST00000044766.15 dynein axonemal assembly factor 9, transcript variant 1 (from RefSeq NM_029432.2) DAAF9_MOUSE Dnaaf9 ENSMUST00000044766.1 ENSMUST00000044766.10 ENSMUST00000044766.11 ENSMUST00000044766.12 ENSMUST00000044766.13 ENSMUST00000044766.14 ENSMUST00000044766.2 ENSMUST00000044766.3 ENSMUST00000044766.4 ENSMUST00000044766.5 ENSMUST00000044766.6 ENSMUST00000044766.7 ENSMUST00000044766.8 ENSMUST00000044766.9 NM_029432 Q3UPD4 Q7TT23 uc008mjx.1 uc008mjx.2 uc008mjx.3 uc008mjx.4 May act as an effector for ARL3. Interacts with ARL3. molecular_function cellular_component biological_process uc008mjx.1 uc008mjx.2 uc008mjx.3 uc008mjx.4 
ENSMUST00000044767.10 Neurod6 ENSMUST00000044767.10 neurogenic differentiation 6 (from RefSeq NM_009717.2) ENSMUST00000044767.1 ENSMUST00000044767.2 ENSMUST00000044767.3 ENSMUST00000044767.4 ENSMUST00000044767.5 ENSMUST00000044767.6 ENSMUST00000044767.7 ENSMUST00000044767.8 ENSMUST00000044767.9 NM_009717 Neurod6 Q5M8T7 Q5M8T7_MOUSE uc009cav.1 uc009cav.2 uc009cav.3 uc009cav.4 uc009cav.5 Efficient DNA binding requires dimerization with another bHLH protein. Nucleus DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development nervous system development cell differentiation protein dimerization activity uc009cav.1 uc009cav.2 uc009cav.3 uc009cav.4 uc009cav.5 
ENSMUST00000044773.12 Frmpd1 ENSMUST00000044773.12 FERM and PDZ domain containing 1, transcript variant 1 (from RefSeq NM_001081172.3) A2AKB4 ENSMUST00000044773.1 ENSMUST00000044773.10 ENSMUST00000044773.11 ENSMUST00000044773.2 ENSMUST00000044773.3 ENSMUST00000044773.4 ENSMUST00000044773.5 ENSMUST00000044773.6 ENSMUST00000044773.7 ENSMUST00000044773.8 ENSMUST00000044773.9 FRPD1_MOUSE Kiaa0967 NM_001081172 Q80TN2 Q80XK5 Q8K0C0 uc008ssi.1 uc008ssi.2 Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1. Interacts with GPSM1 (By similarity). Interacts with GPSM2 (PubMed:23318951). Cytoplasm, cytosol Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Found both in the cytoplasm and associated with the cell membrane. molecular_function cytoplasm cytosol cytoskeleton plasma membrane cell cortex signal transduction regulation of G-protein coupled receptor protein signaling pathway membrane macromolecular complex establishment of protein localization to membrane uc008ssi.1 uc008ssi.2 
ENSMUST00000044776.13 Gls2 ENSMUST00000044776.13 glutaminase 2 (liver, mitochondrial), transcript variant 3 (from RefSeq NM_001285779.1) B2RUF2 ENSMUST00000044776.1 ENSMUST00000044776.10 ENSMUST00000044776.11 ENSMUST00000044776.12 ENSMUST00000044776.2 ENSMUST00000044776.3 ENSMUST00000044776.4 ENSMUST00000044776.5 ENSMUST00000044776.6 ENSMUST00000044776.7 ENSMUST00000044776.8 ENSMUST00000044776.9 GLSL_MOUSE Kiaa4146 NM_001285779 Q3TMJ6 Q571F8 uc007hlo.1 uc007hlo.2 uc007hlo.3 uc007hlo.4 Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. Reaction=H2O + L-glutamine = L-glutamate + NH4(+); Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2; Evidence=; Enzyme activity is not stimulated by phosphate. Phosphate increases kcat, but decreases substrate affinity, resulting in unchanged enzyme activity. Homotetramer, dimer of dimers (By similarity). Does not assemble into higher oligomers (PubMed:23935106). Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with the PDZ domain of TAX1BP3 (By similarity). Mitochondrion Belongs to the glutaminase family. Sequence=BAD90156.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; glutaminase activity mitochondrion glutamate biosynthetic process glutamine metabolic process glutamine catabolic process hydrolase activity regulation of apoptotic process reactive oxygen species metabolic process uc007hlo.1 uc007hlo.2 uc007hlo.3 uc007hlo.4 
ENSMUST00000044789.10 Srpx ENSMUST00000044789.10 sushi-repeat-containing protein, transcript variant 1 (from RefSeq NM_016911.5) A2BE46 A2BE47 ENSMUST00000044789.1 ENSMUST00000044789.2 ENSMUST00000044789.3 ENSMUST00000044789.4 ENSMUST00000044789.5 ENSMUST00000044789.6 ENSMUST00000044789.7 ENSMUST00000044789.8 ENSMUST00000044789.9 NM_016911 Q9R0M2 Q9R0M3 SRPX_MOUSE uc009sqc.1 uc009sqc.2 uc009sqc.3 Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Drs-1; IsoId=Q9R0M3-1; Sequence=Displayed; Name=2; Synonyms=Drs-2; IsoId=Q9R0M3-2; Sequence=VSP_014016; phagolysosome assembly protein binding autophagosome endoplasmic reticulum autophagy response to endoplasmic reticulum stress negative regulation of cell proliferation involved in contact inhibition positive regulation of extrinsic apoptotic signaling pathway in absence of ligand uc009sqc.1 uc009sqc.2 uc009sqc.3 
ENSMUST00000044790.12 Foxn4 ENSMUST00000044790.12 forkhead box N4 (from RefSeq NM_148935.2) ENSMUST00000044790.1 ENSMUST00000044790.10 ENSMUST00000044790.11 ENSMUST00000044790.2 ENSMUST00000044790.3 ENSMUST00000044790.4 ENSMUST00000044790.5 ENSMUST00000044790.6 ENSMUST00000044790.7 ENSMUST00000044790.8 ENSMUST00000044790.9 FOXN4_MOUSE NM_148935 Q0VGP0 Q8K3Q3 Q920C0 uc008yzk.1 uc008yzk.2 uc008yzk.3 Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'- ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development. Nucleus Mainly expressed in proliferator progenitor cells in brain and retina rather than differentiated cells. In contrast, is expressed only in postmitotic epithelial cells rather than in proliferative progenitors in the proximal airway. Expressed in both neural and non-neural tissues of the embryo. In the nervous system, its expression is detected only in a few selected central nervous system tissues including the midbrain, hindbrain, spinal cord and retina while absent from the peripheral nervous system. At about 9.5 dpc-10.5 dpc, commences its expression in the dorsal mesenphalon, ventral rhombencephalon and ventral spinal cord. In the spinal cord, is found in p2 progenitor cells but not in mature V2a and V2b cells, in other interneuron subtypes or in motoneurons. The expression in the brain and spinal cord becomes weak at 12.5 dpc and disappears by 13.5 dpc. In the central eye, expression starts in the central retina at 11.5 dpc, then gradually becomes abundant in the entire retinal outer neuroblastic layer by 13.5 dpc, but is absent from the inner neuroblastic layer. Starting from P1 and by P7, the expression in the retina gradually disappears from the center to the periphery. In airway system, expression turns on at 14.5 dpc in a small set of cells in the epithelia of the trachea and esophagus, then spreads to the epithelia of bronchi and bronchioles by 15.5 dpc, the expression persists until at least P8 (at protein level). Animals display early postnatal lethality, while survivors exhibit noticeable body size reduction starting at P8. At P8 and P20, retinas are reduced in thickness with the inner nuclear layer, inner plexiform layer and ganglion cell layer much thinner than in wild type and lack horizontal cells as well as amacrine cells. In lungs, mutants show dilated alveoli with thin walls. enhancer sequence-specific DNA binding heart looping DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development nervous system development regulation of heart contraction retina layer formation cell differentiation amacrine cell differentiation atrioventricular canal development sequence-specific DNA binding positive regulation of transcription, DNA-templated neuron fate commitment ventral spinal cord interneuron fate commitment uc008yzk.1 uc008yzk.2 uc008yzk.3 
ENSMUST00000044792.6 Rcan2 ENSMUST00000044792.6 regulator of calcineurin 2, transcript variant 2 (from RefSeq NM_030598.2) Dscr1l1 ENSMUST00000044792.1 ENSMUST00000044792.2 ENSMUST00000044792.3 ENSMUST00000044792.4 ENSMUST00000044792.5 NM_030598 Q8VIP5 Q9JHG2 RCAN2_MOUSE Zaki4 uc008cpq.1 uc008cpq.2 uc008cpq.3 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Highest expression in heart, skeletal muscle and brain. Lower expression in all other tissues. Belongs to the RCAN family. Sequence=BAB71955.1; Type=Erroneous initiation; Evidence=; nucleic acid binding cytoplasm response to oxidative stress Notch signaling pathway short-term memory calcium-dependent protein serine/threonine phosphatase regulator activity calcium-mediated signaling locomotion involved in locomotory behavior calcineurin-NFAT signaling cascade regulation of phosphoprotein phosphatase activity regulation of calcineurin-NFAT signaling cascade uc008cpq.1 uc008cpq.2 uc008cpq.3 
ENSMUST00000044795.8 Nup133 ENSMUST00000044795.8 nucleoporin 133 (from RefSeq NM_172288.3) E9QLJ8 ENSMUST00000044795.1 ENSMUST00000044795.2 ENSMUST00000044795.3 ENSMUST00000044795.4 ENSMUST00000044795.5 ENSMUST00000044795.6 ENSMUST00000044795.7 NM_172288 NU133_MOUSE Q8R0G9 uc009nws.1 uc009nws.2 uc009nws.3 Involved in poly(A)+ RNA transport. Involved in nephrogenesis. Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus (By similarity). Nucleus, nuclear pore complex Chromosome, centromere, kinetochore Note=Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores. Belongs to the nucleoporin Nup133 family. chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed chromosome outer kinetochore nucleus nuclear pore chromosome mRNA export from nucleus protein import into nucleus nuclear pore organization protein transport structural constituent of nuclear pore neural tube development neurogenesis nuclear pore outer ring nuclear pore distribution nuclear membrane paraxial mesoderm development mRNA transport somite development nephron development uc009nws.1 uc009nws.2 uc009nws.3 
ENSMUST00000044804.8 Cdsn ENSMUST00000044804.8 corneodesmosin, transcript variant 1 (from RefSeq NM_001008424.3) CDSN_MOUSE E9QLN3 ENSMUST00000044804.1 ENSMUST00000044804.2 ENSMUST00000044804.3 ENSMUST00000044804.4 ENSMUST00000044804.5 ENSMUST00000044804.6 ENSMUST00000044804.7 NM_001008424 Q7TPC1 uc008cia.1 uc008cia.2 Important for the epidermal barrier integrity. Secreted. Note=Found in corneodesmosomes, the intercellular structures that are involved in desquamation. extracellular region extracellular space desmosome protein homodimerization activity skin morphogenesis cell-cell adhesion uc008cia.1 uc008cia.2 
ENSMUST00000044806.3 Dnaaf6 ENSMUST00000044806.3 dynein axonemal assembly factor 6 (from RefSeq NM_177921.3) Dnaaf6 Dnaaf6b E230019M04Rik ENSMUST00000044806.1 ENSMUST00000044806.2 NM_177921 Pih1h3b Q8C6P5 Q8C6P5_MOUSE uc009ukw.1 uc009ukw.2 Belongs to the PIH1 family. molecular_function cellular_component biological_process uc009ukw.1 uc009ukw.2 
ENSMUST00000044819.7 Gm28044 ENSMUST00000044819.7 Gm28044 (from geneSymbol) AK166568 ENSMUST00000044819.1 ENSMUST00000044819.2 ENSMUST00000044819.3 ENSMUST00000044819.4 ENSMUST00000044819.5 ENSMUST00000044819.6 Gm28044 L7N1X0 L7N1X0_MOUSE uc288oej.1 uc288oej.2 nucleic acid binding regulation of transcription, DNA-templated uc288oej.1 uc288oej.2 
ENSMUST00000044823.4 Zswim5 ENSMUST00000044823.4 zinc finger SWIM-type containing 5 (from RefSeq NM_001029912.3) ENSMUST00000044823.1 ENSMUST00000044823.2 ENSMUST00000044823.3 Kiaa1511 NM_001029912 Q80TC6 ZSWM5_MOUSE uc008uhq.1 uc008uhq.2 uc008uhq.3 molecular_function zinc ion binding Cul2-RING ubiquitin ligase complex metal ion binding regulation of axon guidance uc008uhq.1 uc008uhq.2 uc008uhq.3 
ENSMUST00000044825.5 Ndufaf5 ENSMUST00000044825.5 NADH:ubiquinone oxidoreductase complex assembly factor 5 (from RefSeq NM_027093.4) A2APY7 ENSMUST00000044825.1 ENSMUST00000044825.2 ENSMUST00000044825.3 ENSMUST00000044825.4 NDUF5_MOUSE NM_027093 Ndufaf5 Q9D7L6 uc008mpo.1 uc008mpo.2 uc008mpo.3 uc008mpo.4 Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT- ND1) at early stages. Acts by mediating hydroxylation of 'Arg-111' of NDUFS7. May also have methyltransferase activity. Interacts with NDUFAF8, leading to stabilize NDUFAF5. Interacts with NDUFS7. Interacts with PYURF (via TRM112 domain); the interaction is direct and stabilizes NDUFAF5 protein (By similarity). Mitochondrion inner membrane Note=Peripherally localized on the matrix face of the mitochondrial inner membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2APY7-1; Sequence=Displayed; Name=2; IsoId=A2APY7-2; Sequence=VSP_028638; Belongs to the methyltransferase superfamily. Sequence=AAH05630.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function mitochondrion mitochondrial inner membrane methyltransferase activity membrane oxidoreductase activity transferase activity peptidyl-arginine hydroxylation extrinsic component of mitochondrial inner membrane methylation mitochondrial respiratory chain complex I assembly oxidation-reduction process uc008mpo.1 uc008mpo.2 uc008mpo.3 uc008mpo.4 
ENSMUST00000044828.14 Lgr6 ENSMUST00000044828.14 leucine-rich repeat-containing G protein-coupled receptor 6, transcript variant 6 (from RefSeq NR_184714.1) B2RUL8 ENSMUST00000044828.1 ENSMUST00000044828.10 ENSMUST00000044828.11 ENSMUST00000044828.12 ENSMUST00000044828.13 ENSMUST00000044828.2 ENSMUST00000044828.3 ENSMUST00000044828.4 ENSMUST00000044828.5 ENSMUST00000044828.6 ENSMUST00000044828.7 ENSMUST00000044828.8 ENSMUST00000044828.9 LGR6_MOUSE NR_184714 Q3UVD5 Q80UB8 Q8R301 uc007csq.1 uc007csq.2 uc007csq.3 Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal (By similarity). Cell membrane ; Multi-pass membrane protein Specifically expressed in multipotent stem cells in the epidermis. Expressed in the earliest embryonic hair placodes. In adult hair follicles, present in a region directly above the follicle bulge. Specifically present in prenatal cells establishing the hair follicle, sebaceous gland and interfollicular epidermis. Postnatally, present in cells generating sebaceous gland and interfollicular epidermis (PubMed:20223988). During limb development, at 14.5 dpc, expressed in the ectoderm overlying the limb buds and at the apical ectodermal ridge. In the developing lungs, at 14.5 dpc, expressed in smooth muscle cells (PubMed:29769720). Simultaneous knockdown of LGR4, LGR5 and LGR6 results in developmental phenotypes, such as cleft palate and ankyloglossia, but not in tetra-amelia with lung agenesis. Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity extracellular space plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane Wnt signaling pathway protein-hormone receptor activity positive regulation of Wnt signaling pathway positive regulation of cell migration extracellular matrix vesicle tissue regeneration bone regeneration uc007csq.1 uc007csq.2 uc007csq.3 
ENSMUST00000044829.5 4921524L21Rik ENSMUST00000044829.5 RIKEN cDNA 4921524L21 gene, transcript variant 1 (from RefSeq NM_027598.2) 4921524L21Rik ENSMUST00000044829.1 ENSMUST00000044829.2 ENSMUST00000044829.3 ENSMUST00000044829.4 NM_027598 Q9D5T2 Q9D5T2_MOUSE uc008dzm.1 uc008dzm.2 uc008dzm.3 uc008dzm.4 molecular_function cellular_component biological_process uc008dzm.1 uc008dzm.2 uc008dzm.3 uc008dzm.4 
ENSMUST00000044833.9 Oas3 ENSMUST00000044833.9 2'-5' oligoadenylate synthetase 3 (from RefSeq NM_145226.2) B9EIU4 ENSMUST00000044833.1 ENSMUST00000044833.2 ENSMUST00000044833.3 ENSMUST00000044833.4 ENSMUST00000044833.5 ENSMUST00000044833.6 ENSMUST00000044833.7 ENSMUST00000044833.8 NM_145226 OAS3_MOUSE Q8K4D2 Q8VI93 oasl10 uc008zhz.1 uc008zhz.2 uc008zhz.3 Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Reaction=3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')- adenosine + 2 diphosphate; Xref=Rhea:RHEA:34407, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:67143; EC=2.7.7.84; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. Strongly activated by long dsRNAs at least 50 nucleotides in length. ssRNA does not activate the enzyme. Monomer. Cytoplasm Nucleus Intestine. By type I interferon (IFN) and viruses. OAS domain 3 is catalytically active. OAS domain 1 has no catalytic activity but is essential for recognition of long dsRNAs. Belongs to the 2-5A synthase family. nucleotide binding 2'-5'-oligoadenylate synthetase activity immune system process RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm cytoplasm cytosol plasma membrane immune response response to virus transferase activity nucleotidyltransferase activity negative regulation of viral genome replication innate immune response metal ion binding defense response to virus regulation of ribonuclease activity uc008zhz.1 uc008zhz.2 uc008zhz.3 
ENSMUST00000044844.9 Mfsd12 ENSMUST00000044844.9 major facilitator superfamily domain containing 12 (from RefSeq NM_028657.4) ENSMUST00000044844.1 ENSMUST00000044844.2 ENSMUST00000044844.3 ENSMUST00000044844.4 ENSMUST00000044844.5 ENSMUST00000044844.6 ENSMUST00000044844.7 ENSMUST00000044844.8 MFS12_MOUSE Mfsd12 NM_028657 Q3U376 Q3U481 uc007gho.1 uc007gho.2 uc007gho.3 Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin/hair pigmentation (PubMed:33208952). In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin/hair pigmentation (PubMed:33208952). Also catalyzes import of cysteine into lysosomes in non-pigmented cells, regulating lysosomal cystine and cysteine storage, which is essnetial for redox homeostasis (By similarity). Reaction=L-cysteine(in) = L-cysteine(out); Xref=Rhea:RHEA:29655, ChEBI:CHEBI:35235; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29656; Evidence=; Melanosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Phosphorylation at Thr-251 by MTOR via mTORC1 pathway promotes cysteine transport in lysosomes, thereby regulating lysosomal cysteine and cystine storage and redox homeostasis. Mice are darker and display a uniformly gray coat color, rather than the expected agouti coat color (PubMed:29025994). Coat color change is caused by a lack of pheomelanin, resulting in white, rather than yellow, banding of hairs (PubMed:29025994). Belongs to the major facilitator superfamily. integral component of plasma membrane carbohydrate transport symporter activity membrane integral component of membrane transmembrane transport organic substance transport uc007gho.1 uc007gho.2 uc007gho.3 
ENSMUST00000044850.4 Abca9 ENSMUST00000044850.4 ATP-binding cassette, sub-family A member 9 (from RefSeq NM_147220.2) A2A6R5 ABCA9_MOUSE ENSMUST00000044850.1 ENSMUST00000044850.2 ENSMUST00000044850.3 NM_147220 Q8C114 Q8K449 uc007mdh.1 uc007mdh.2 uc007mdh.3 Transporter that may play a role in monocyte differentiation and lipid transport and homeostasis. Membrane ; Multi-pass membrane protein Highly expressed in heart and to lower extent in kidney, brain and spleen (PubMed:12532264). Weakly expressed in developing and adult brains (PubMed:29520568). Weakly expressed in the cerebellar granular layer at P14 and P21 (PubMed:29520568). Detected along the outer surface of the brain or along the fissure of cerebellar lobules at 13 dpc to P21. Down-regulated by digoxin. Belongs to the ABC transporter superfamily. ABCA family. nucleotide binding lipid transporter activity ATP binding mitochondrion lipid transport membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances intracellular membrane-bounded organelle transmembrane transport uc007mdh.1 uc007mdh.2 uc007mdh.3 
ENSMUST00000044851.8 Pcdhga12 ENSMUST00000044851.8 protocadherin gamma subfamily A, 12 (from RefSeq NM_033595.4) ENSMUST00000044851.1 ENSMUST00000044851.2 ENSMUST00000044851.3 ENSMUST00000044851.4 ENSMUST00000044851.5 ENSMUST00000044851.6 ENSMUST00000044851.7 NM_033595 Pcdhga12 Q91XY7 Q91XY7_MOUSE uc008erd.1 uc008erd.2 uc008erd.3 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding protein binding plasma membrane integral component of plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules uc008erd.1 uc008erd.2 uc008erd.3 
ENSMUST00000044857.4 Trappc5 ENSMUST00000044857.4 trafficking protein particle complex 5 (from RefSeq NM_025701.4) ENSMUST00000044857.1 ENSMUST00000044857.2 ENSMUST00000044857.3 NM_025701 Q8BJX6 Q9CQA1 TPPC5_MOUSE uc009ksk.1 uc009ksk.2 uc009ksk.3 uc009ksk.4 May play a role in vesicular transport from endoplasmic reticulum to Golgi. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Q9CQA1; Q9Y296: TRAPPC4; Xeno; NbExp=2; IntAct=EBI-1172213, EBI-722888; Golgi apparatus, cis-Golgi network Endoplasmic reticulum Belongs to the TRAPP small subunits family. BET3 subfamily. protein binding endoplasmic reticulum Golgi apparatus ER to Golgi vesicle-mediated transport vesicle-mediated transport TRAPP complex Golgi vesicle transport TRAPPI protein complex TRAPPII protein complex TRAPPIII protein complex Rab guanyl-nucleotide exchange factor activity uc009ksk.1 uc009ksk.2 uc009ksk.3 uc009ksk.4 
ENSMUST00000044878.4 Akp3 ENSMUST00000044878.4 alkaline phosphatase 3, intestine, not Mn requiring (from RefSeq NM_007432.3) Akp3 ENSMUST00000044878.1 ENSMUST00000044878.2 ENSMUST00000044878.3 F8VQM0 F8VQM0_MOUSE NM_007432 uc007bwb.1 uc007bwb.2 Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.1; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions. ; Homodimer. Cell membrane ; Lipid-anchor, GPI-anchor Membrane ; Lipid-anchor, GPI-anchor Belongs to the alkaline phosphatase family. magnesium ion binding catalytic activity alkaline phosphatase activity phosphorus metabolic process zinc ion binding external side of plasma membrane dephosphorylation hydrolase activity phosphatase activity response to nutrient levels uc007bwb.1 uc007bwb.2 
ENSMUST00000044911.10 Stub1 ENSMUST00000044911.10 STIP1 homology and U-Box containing protein 1, transcript variant 1 (from RefSeq NM_019719.4) CHIP_MOUSE Chip ENSMUST00000044911.1 ENSMUST00000044911.2 ENSMUST00000044911.3 ENSMUST00000044911.4 ENSMUST00000044911.5 ENSMUST00000044911.6 ENSMUST00000044911.7 ENSMUST00000044911.8 ENSMUST00000044911.9 NM_019719 Q9DCJ0 Q9WUD1 Stub1 uc008bcf.1 uc008bcf.2 uc008bcf.3 E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:11435423, PubMed:21855799). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:11435423, PubMed:21855799). Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (By similarity). Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (By similarity). Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (By similarity). Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (By similarity). Mediates polyubiquitination of CYP3A4 (By similarity). Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (By similarity). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation. Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (PubMed:24043303). Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD- L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (By similarity). Negatively regulates TGF- beta signaling by modulating the basal level of SMAD3 via ubiquitin- mediated degradation (By similarity). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (By similarity). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence= Protein modification; protein ubiquitination. Homodimer (PubMed:16307917). Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1. Interacts with MKKS. Interacts with DNAAF4 (By similarity). Interacts (via the U-box domain) with the UBE2V2-UBE2N heterodimer; the complex has a specific 'Lys-63'-linked polyubiquitination activity (PubMed:16307917). Interacts (when monoubiquitinated) with ATXN3 (PubMed:21855799). Interacts with UBE2W (PubMed:21855799). Interacts with DNAJB6 (By similarity). Interacts with FLCN and HSP90AA1. Interacts with HSP90. Interacts with UBE2N and UBE2V1. Interacts (via TPR repeats) with the C-terminal domains of HSPA8 and HSPA1A. Interacts with the non- acetylated form of HSPA1A and HSPA1B. Interacts with SMAD3 and HSP90AB1 (By similarity). Interacts with UBE4B (By similarity). Interacts with PRMT5 (By similarity). Q9WUD1; O55222: Ilk; NbExp=7; IntAct=EBI-773027, EBI-6690138; Q9WUD1; Q5S007: LRRK2; Xeno; NbExp=2; IntAct=EBI-773027, EBI-5323863; Q9WUD1; P61088: UBE2N; Xeno; NbExp=2; IntAct=EBI-773027, EBI-1052908; Cytoplasm Nucleus Note=Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg). Up-regulated by inflammatory signals in Treg regulatory T- cells (Treg). The U-box domain is required for the ubiquitin protein ligase activity. The TPR domain is essential for ubiquitination mediated by UBE2D1. Auto-ubiquitinated; mediated by UBE2D1 and UBE2D2. Monoubiquitinated at Lys-2 following cell stress by UBE2W, promoting the interaction with ATXN3. ubiquitin ligase complex protein polyubiquitination G-protein coupled receptor binding response to ischemia ubiquitin-protein transferase activity protein binding nucleus nucleoplasm cytoplasm endoplasmic reticulum cytosol DNA repair protein folding ubiquitin-dependent protein catabolic process misfolded or incompletely synthesized protein catabolic process cellular response to DNA damage stimulus protein ubiquitination transferase activity enzyme binding kinase binding Z disc ER-associated ubiquitin-dependent protein catabolic process negative regulation of transforming growth factor beta receptor signaling pathway Hsp70 protein binding ubiquitin-dependent SMAD protein catabolic process protein binding, bridging TPR domain binding endoplasmic reticulum unfolded protein response heat shock protein binding ubiquitin conjugating enzyme complex positive regulation of protein ubiquitination ubiquitin protein ligase binding regulation of protein stability regulation of glucocorticoid metabolic process negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-ubiquitin ligase activity cellular response to heat nuclear inclusion body protein homodimerization activity proteasome-mediated ubiquitin-dependent protein catabolic process SMAD binding chaperone binding positive regulation of ubiquitin-protein transferase activity protein maturation misfolded protein binding protein autoubiquitination Hsp90 protein binding ubiquitin protein ligase activity chaperone-mediated autophagy protein K63-linked ubiquitination cellular response to misfolded protein cellular response to hypoxia positive regulation of chaperone-mediated protein complex assembly uc008bcf.1 uc008bcf.2 uc008bcf.3 
ENSMUST00000044922.8 Hs3st6 ENSMUST00000044922.8 heparan sulfate (glucosamine) 3-O-sulfotransferase 6, transcript variant 3 (from RefSeq NM_001357342.1) ENSMUST00000044922.1 ENSMUST00000044922.2 ENSMUST00000044922.3 ENSMUST00000044922.4 ENSMUST00000044922.5 ENSMUST00000044922.6 ENSMUST00000044922.7 HS3S6_MOUSE NM_001357342 Q5GFD5 uc008ayj.1 uc008ayj.2 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:15461, Rhea:RHEA- COMP:9830, Rhea:RHEA-COMP:9831, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:70975; EC=2.8.2.23; Golgi apparatus membrane ; Single- pass type II membrane protein Expressed in liver and kidney, followed by heart, brain, lung and testis. Belongs to the sulfotransferase 1 family. Golgi membrane blastocyst hatching cellular_component Golgi apparatus sulfotransferase activity [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity membrane integral component of membrane transferase activity uc008ayj.1 uc008ayj.2 
ENSMUST00000044923.15 Ddx24 ENSMUST00000044923.15 DEAD box helicase 24, transcript variant 2 (from RefSeq NM_020494.4) DDX24_MOUSE ENSMUST00000044923.1 ENSMUST00000044923.10 ENSMUST00000044923.11 ENSMUST00000044923.12 ENSMUST00000044923.13 ENSMUST00000044923.14 ENSMUST00000044923.2 ENSMUST00000044923.3 ENSMUST00000044923.4 ENSMUST00000044923.5 ENSMUST00000044923.6 ENSMUST00000044923.7 ENSMUST00000044923.8 ENSMUST00000044923.9 NM_020494 Q61119 Q7TM97 Q9ESV0 uc007ovj.1 uc007ovj.2 uc007ovj.3 uc007ovj.4 ATP-dependent RNA helicase. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleolus hydrolase activity uc007ovj.1 uc007ovj.2 uc007ovj.3 uc007ovj.4 
ENSMUST00000044926.6 Odad3 ENSMUST00000044926.6 outer dynein arm docking complex subunit 3, transcript variant 2 (from RefSeq NM_029939.3) Ccdc151 ENSMUST00000044926.1 ENSMUST00000044926.2 ENSMUST00000044926.3 ENSMUST00000044926.4 ENSMUST00000044926.5 G3X951 NM_029939 ODAD3 ODAD3_MOUSE Q6PGE8 Q8BSN3 Q9CWC6 uc009ong.1 uc009ong.2 uc009ong.3 Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). May be required for motile cilia function (PubMed:24067530). Component of the outer dynein arm-docking complex along with ODAD1, ODAD2, ODAD4 and CLXN (By similarity). Interacts with ODAD1 (By similarity). Interacts with PIERCE1 and PIERCE2; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme (By similarity). Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Enriched at centrioles in IMCD3 dividing cells. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BSN3-1; Sequence=Displayed; Name=2; IsoId=Q8BSN3-2; Sequence=VSP_031786, VSP_031787; Name=3; IsoId=Q8BSN3-3; Sequence=VSP_031788; At 7.5 dpc specifically expressed in the ventral node. Mice have a spectrum of laterality defects, including complex congenital heart defects associated with heterotaxy, and airway epithelia show largely immotile cilia with loss of the outer dynein arms. cilium movement molecular_function cytoplasm centriole cytoskeleton cilium axoneme determination of left/right symmetry heart development cell projection organization ciliary basal body outer dynein arm assembly cell projection determination of heart left/right asymmetry axonemal dynein complex assembly regulation of cilium assembly uc009ong.1 uc009ong.2 uc009ong.3 
ENSMUST00000044949.11 Dph1 ENSMUST00000044949.11 diphthamide biosynthesis 1 (from RefSeq NM_144491.2) DPH1_MOUSE Dph1 Dph2l1 ENSMUST00000044949.1 ENSMUST00000044949.10 ENSMUST00000044949.2 ENSMUST00000044949.3 ENSMUST00000044949.4 ENSMUST00000044949.5 ENSMUST00000044949.6 ENSMUST00000044949.7 ENSMUST00000044949.8 ENSMUST00000044949.9 NM_144491 Ovca1 Q5NCQ5 Q80UX6 Q8R445 uc007kdg.1 uc007kdg.2 uc007kdg.3 Catalyzes the first step of diphthamide biosynthesis, a post- translational modification of histidine which occurs in elongation factor 2 (PubMed:15485916, PubMed:24895408). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Acts as a tumor suppressor (PubMed:14744934, PubMed:15661533, PubMed:24895408). Reaction=L-histidyl-[translation elongation factor 2] + S-adenosyl-L- methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine; Xref=Rhea:RHEA:36783, Rhea:RHEA-COMP:9748, Rhea:RHEA-COMP:9749, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:29979, ChEBI:CHEBI:59789, ChEBI:CHEBI:73995; EC=2.5.1.108; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. ; Protein modification; peptidyl-diphthamide biosynthesis. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase (By similarity). Interacts with DPH2 (PubMed:15485916, PubMed:21203470). Interacts with RBM8A (By similarity). Q5NCQ5; Q9CR25: Dph2; NbExp=2; IntAct=EBI-1561119, EBI-1561134; Nucleus Cytoplasm Note=Punctate, primarily perinuclear localization. Strongly expressed in kidney and liver. Moderately expressed in brain, skin and testis. Weakly expressed in heart, lung, small intestine, spleen, stomach and thymus. Expressed in heart, neural tube, forebrain, mandible, tongue and body walls at 10.5 to 14.5 dpc (at protein level) (PubMed:24895408). Expressed in lung, stomach, brain, heart, kidney and gonads at 14.5 dpc (PubMed:11527402). Global developmental delay (PubMed:14744934, PubMed:24895408). Abnormal palatogenesis; palatine bone absent, micrognathia, cleft palate and small skull (PubMed:14744934, PubMed:24895408). Results in death during gestation or soon after birth with a small body size (PubMed:14744934). May also result in preaxial polydactyly of the right hindlimb and abnormal hepatic development (PubMed:14744934). Knockout mice leads to an increased frequency of tumor formation (PubMed:14744934, PubMed:24895408). Belongs to the DPH1/DPH2 family. DPH1 subfamily. protein binding nucleus nucleoplasm cytoplasm cell proliferation transferase activity peptidyl-diphthamide biosynthetic process from peptidyl-histidine cell junction uc007kdg.1 uc007kdg.2 uc007kdg.3 
ENSMUST00000044953.3 Semg1 ENSMUST00000044953.3 semenogelin 1 (from RefSeq NM_017390.4) ENSMUST00000044953.1 ENSMUST00000044953.2 NM_017390 Q8BS30 Q8BS30_MOUSE Semg1 Svs2 uc008nub.1 uc008nub.2 uc008nub.3 uc008nub.4 acrosomal vesicle fertilization sperm capacitation uc008nub.1 uc008nub.2 uc008nub.3 uc008nub.4 
ENSMUST00000044954.7 Slc30a1 ENSMUST00000044954.7 solute carrier family 30 (zinc transporter), member 1 (from RefSeq NM_009579.3) ENSMUST00000044954.1 ENSMUST00000044954.2 ENSMUST00000044954.3 ENSMUST00000044954.4 ENSMUST00000044954.5 ENSMUST00000044954.6 NM_009579 Q60738 Slc30a1 ZNT1_MOUSE Znt1 uc007edc.1 uc007edc.2 uc007edc.3 Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (Probable). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (PubMed:15451416). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (By similarity). Reaction=2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out); Xref=Rhea:RHEA:72627, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105; Evidence=; Homodimer. Interacts with TMEM163 (By similarity). Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Note=Localization to the plasma membrane is regulated by cellular zinc status. Recruitment to the plasma membrane from an internal pool is stimulated by zinc while in absence of zinc the plasma membrane pool is endocytosed and degraded (By similarity). Localizes to the basolateral surface of enterocytes (By similarity). Localizes to zinc-containing intracellular vesicles in macrophages (By similarity). Widely expressed. Knockout of Slc30a1 is embryonic lethal. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. in utero embryonic development zinc ion transmembrane transporter activity cytoplasm endoplasmic reticulum Golgi apparatus plasma membrane ion transport cation transport zinc II ion transport cellular calcium ion homeostasis cellular zinc ion homeostasis cation transmembrane transporter activity membrane integral component of membrane calcium channel inhibitor activity T-tubule nuclear membrane negative regulation of neurotransmitter secretion transmembrane transport calcium ion import cadmium ion transmembrane transport zinc II ion transmembrane transport negative regulation of zinc ion transmembrane import detoxification of cadmium ion negative regulation of calcium ion import integral component of postsynaptic density membrane uc007edc.1 uc007edc.2 uc007edc.3 
ENSMUST00000044970.7 Mgat3 ENSMUST00000044970.7 mannoside acetylglucosaminyltransferase 3 (from RefSeq NM_010795.4) ENSMUST00000044970.1 ENSMUST00000044970.2 ENSMUST00000044970.3 ENSMUST00000044970.4 ENSMUST00000044970.5 ENSMUST00000044970.6 Mgat3 NM_010795 Q5RKT9 Q5RKT9_MOUSE uc007wvf.1 uc007wvf.2 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity protein N-linked glycosylation protein localization membrane transferase activity regulation of cell migration uc007wvf.1 uc007wvf.2 
ENSMUST00000044976.12 Glyat ENSMUST00000044976.12 glycine-N-acyltransferase (from RefSeq NM_145935.3) ENSMUST00000044976.1 ENSMUST00000044976.10 ENSMUST00000044976.11 ENSMUST00000044976.2 ENSMUST00000044976.3 ENSMUST00000044976.4 ENSMUST00000044976.5 ENSMUST00000044976.6 ENSMUST00000044976.7 ENSMUST00000044976.8 ENSMUST00000044976.9 GLYAT_MOUSE NM_145935 Q05DG2 Q91XE0 uc008guh.1 uc008guh.2 uc008guh.3 Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. Reaction=an acyl-CoA + glycine = an N-acylglycine + CoA + H(+); Xref=Rhea:RHEA:19869, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57670, ChEBI:CHEBI:58342; EC=2.3.1.13; Evidence=; Reaction=benzoyl-CoA + glycine = CoA + H(+) + N-benzoylglycine; Xref=Rhea:RHEA:18493, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57369, ChEBI:CHEBI:606565; EC=2.3.1.71; Evidence=; Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91XE0-1; Sequence=Displayed; Name=2; IsoId=Q91XE0-2; Sequence=VSP_024075; Belongs to the glycine N-acyltransferase family. mitochondrion glycine metabolic process response to toxic substance transferase activity transferase activity, transferring acyl groups monocarboxylic acid metabolic process glycine N-acyltransferase activity glycine N-benzoyltransferase activity benzoyl-CoA metabolic process uc008guh.1 uc008guh.2 uc008guh.3 
ENSMUST00000044977.10 Slc25a16 ENSMUST00000044977.10 solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16, transcript variant 1 (from RefSeq NM_175194.3) B2RSS4 ENSMUST00000044977.1 ENSMUST00000044977.2 ENSMUST00000044977.3 ENSMUST00000044977.4 ENSMUST00000044977.5 ENSMUST00000044977.6 ENSMUST00000044977.7 ENSMUST00000044977.8 ENSMUST00000044977.9 GDC_MOUSE Gda NM_175194 Q6P6K8 Q8C0K5 Slc25a16 uc007fjh.1 uc007fjh.2 uc007fjh.3 May be involved in the transport of coenzyme A in the mitochondrial matrix. Very little is known about the physiological function of this carrier. Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C0K5-1; Sequence=Displayed; Name=2; IsoId=Q8C0K5-2; Sequence=VSP_016549, VSP_016550; Belongs to the mitochondrial carrier (TC 2.A.29) family. mitochondrion mitochondrial inner membrane membrane integral component of membrane transmembrane transporter activity transmembrane transport uc007fjh.1 uc007fjh.2 uc007fjh.3 
ENSMUST00000044987.3 H2ap ENSMUST00000044987.3 H2A.P histone (from RefSeq NM_026096.1) ENSMUST00000044987.1 ENSMUST00000044987.2 H2ap HYPM_MOUSE Hypm NM_026096 Q9CR04 uc009spz.1 uc009spz.2 uc009spz.3 May interact with the N-terminus of HD. nucleosome nuclear chromatin DNA binding nucleus chromatin organization protein heterodimerization activity uc009spz.1 uc009spz.2 uc009spz.3 
ENSMUST00000044989.12 Fam90a1b ENSMUST00000044989.12 Belongs to the FAM90 family. (from UniProt Q9D4F3) 4932442L08Rik AK016569 ENSMUST00000044989.1 ENSMUST00000044989.10 ENSMUST00000044989.11 ENSMUST00000044989.2 ENSMUST00000044989.3 ENSMUST00000044989.4 ENSMUST00000044989.5 ENSMUST00000044989.6 ENSMUST00000044989.7 ENSMUST00000044989.8 ENSMUST00000044989.9 Fam90a1b Q9D4F3 Q9D4F3_MOUSE uc009ttk.1 uc009ttk.2 Belongs to the FAM90 family. molecular_function cellular_component biological_process uc009ttk.1 uc009ttk.2 
ENSMUST00000045004.11 Dop1b ENSMUST00000045004.11 DOP1 leucine zipper like protein B, transcript variant 1 (from RefSeq NM_027293.1) DOP2_MOUSE Dopey2 E9QLV2 ENSMUST00000045004.1 ENSMUST00000045004.10 ENSMUST00000045004.2 ENSMUST00000045004.3 ENSMUST00000045004.4 ENSMUST00000045004.5 ENSMUST00000045004.6 ENSMUST00000045004.7 ENSMUST00000045004.8 ENSMUST00000045004.9 Kiaa0933 NM_027293 Q3UH78 Q3UHQ6 Q80TN8 uc007zzv.1 uc007zzv.2 uc007zzv.3 May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer- mediated endosomal sorting of WLS away from lysosomal degradation. Homooligomer. Heterotrimer with ATP9A and MON2; this interaction is retromer-independent. Interacts with SNX3. Early endosome membrane Golgi apparatus membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UHQ6-1; Sequence=Displayed; Name=2; IsoId=Q3UHQ6-2; Sequence=VSP_027430; Expressed in liver, heart and brain. Highly expressed in developing nervous system. Belongs to the dopey family. Golgi membrane molecular_function endosome Golgi apparatus trans-Golgi network cytosol Golgi to endosome transport protein transport membrane cognition uc007zzv.1 uc007zzv.2 uc007zzv.3 
ENSMUST00000045008.8 Nat8f2 ENSMUST00000045008.8 N-acetyltransferase 8 (GCN5-related) family member 2 (from RefSeq NM_053096.3) Cml2 ENSMUST00000045008.1 ENSMUST00000045008.2 ENSMUST00000045008.3 ENSMUST00000045008.4 ENSMUST00000045008.5 ENSMUST00000045008.6 ENSMUST00000045008.7 NM_053096 NT8F2_MOUSE Nat8f2 Q8C7E5 Q8CHQ9 Q9JIY9 uc009cqi.1 uc009cqi.2 uc009cqi.3 Probable acetyltransferase (Probable). Has no detectable histone acetyltransferase activity towards histone H3 or H4. Membrane ; Multi-pass membrane protein Belongs to the camello family. gastrulation with mouth forming second endoplasmic reticulum Golgi apparatus negative regulation of cell adhesion N-acetyltransferase activity membrane integral component of membrane transferase activity extracellular space uc009cqi.1 uc009cqi.2 uc009cqi.3 
ENSMUST00000045011.9 Atrip ENSMUST00000045011.9 ATR interacting protein (from RefSeq NM_172774.3) ATRIP_MOUSE E9QLS8 ENSMUST00000045011.1 ENSMUST00000045011.2 ENSMUST00000045011.3 ENSMUST00000045011.4 ENSMUST00000045011.5 ENSMUST00000045011.6 ENSMUST00000045011.7 ENSMUST00000045011.8 NM_172774 Q8BMG1 uc009rru.1 uc009rru.2 uc009rru.3 uc009rru.4 Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein (By similarity). Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single-stranded DNA. Interacts with CINP (By similarity). Interacts with ATR. Q8BMG1; Q9JKK8: Atr; NbExp=2; IntAct=EBI-5235246, EBI-1202426; Nucleus Note=Redistributes to discrete nuclear foci upon DNA damage. Interacts with CEP164 (via N- terminus) (By similarity). The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage. Phosphorylated by ATR. Belongs to the ATRIP family. DNA damage checkpoint protein binding nucleus DNA repair cellular response to DNA damage stimulus K63-linked polyubiquitin binding uc009rru.1 uc009rru.2 uc009rru.3 uc009rru.4 
ENSMUST00000045016.9 Cct8l1 ENSMUST00000045016.9 chaperonin containing TCP1 subunit 8-like 1 (from RefSeq NM_198621.2) Cct8l1 ENSMUST00000045016.1 ENSMUST00000045016.2 ENSMUST00000045016.3 ENSMUST00000045016.4 ENSMUST00000045016.5 ENSMUST00000045016.6 ENSMUST00000045016.7 ENSMUST00000045016.8 Gm443 NM_198621 Q80YT3 Q80YT3_MOUSE uc008wsz.1 uc008wsz.2 Belongs to the TCP-1 chaperonin family. nucleotide binding ATP binding cytoplasm chaperonin-containing T-complex protein folding unfolded protein binding uc008wsz.1 uc008wsz.2 
ENSMUST00000045022.9 Nlrp2 ENSMUST00000045022.9 NLR family, pyrin domain containing 2 (from RefSeq NM_177690.3) ENSMUST00000045022.1 ENSMUST00000045022.2 ENSMUST00000045022.3 ENSMUST00000045022.4 ENSMUST00000045022.5 ENSMUST00000045022.6 ENSMUST00000045022.7 ENSMUST00000045022.8 NM_177690 Nalp2 Nlrp2 Q4PLS0 Q4PLS0_MOUSE uc009fae.1 uc009fae.2 Belongs to the NLRP family. nucleotide binding ATP binding cytoplasm Golgi apparatus cytosol negative regulation of NF-kappaB transcription factor activity Pyrin domain binding intracellular membrane-bounded organelle positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of interleukin-1 beta secretion nuclear chromosome, telomeric region uc009fae.1 uc009fae.2 
ENSMUST00000045026.4 Spag5 ENSMUST00000045026.4 sperm associated antigen 5, transcript variant 2 (from RefSeq NR_156178.1) B1AQC8 ENSMUST00000045026.1 ENSMUST00000045026.2 ENSMUST00000045026.3 NR_156178 Q7TME2 Q8CH61 SPAG5_MOUSE uc007kiv.1 uc007kiv.2 uc007kiv.3 uc007kiv.4 Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (By similarity). Homodimer, with a globular head domain and a long stalk. Homooligomer; the globular head domains associate, resulting in aster- like structures. Binds to microtubules in the mitotic spindle. Interacts with DCLRE1B/Apollo. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with KNSTRN. Interacts with RPTOR; this interaction competes with RPTOR binding to MTOR, resulting in decreased mTORC1 formation. Interacts with G3BP1. The complex formed with G3BP1 and RPTOR is increased by oxidative stress. Interacts with OSBPL8, PCM1 and CDK5RAP2. Interacts (via C-terminus) with NUMA1 (via C-terminus); this interaction promotes the recruitment of SPAG5 to the microtubules at spindle poles in a dynein-dynactin-dependent manner. Interacts with DYNLL1 (By similarity). Cytoplasm Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Chromosome, centromere, kinetochore Midbody Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Note=Colocalizes with PCM1 at centriolar satellites throughout the cell cycle (By similarity). In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase. Efficient targeting to the mitotic spindle may depend upon phosphorylation by GSK3B. Detected on kinetochores of chromosomes that have congressed. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (By similarity). In non-mitotic non- stressed cells, shows a microtubuli pattern. During oxidative stress, accumulates in stress granules (By similarity). Detected in testis, but not in the other tissues tested. Expression is cell cycle-regulated, with an increase from prophase to cytokinesis and return to basal levels at the next G1 phase. Phosphorylated by AURKA. mitotic sister chromatid segregation chromosome, centromeric region kinetochore condensed chromosome kinetochore spindle pole chromosome cytoplasm microtubule organizing center spindle cytoskeleton microtubule cell cycle spindle organization chromosome segregation microtubule binding midbody positive regulation of intracellular transport centriolar satellite microtubule plus-end establishment of spindle orientation cell division regulation of attachment of spindle microtubules to kinetochore protein localization to centrosome mitotic spindle regulation of metaphase plate congression mitotic spindle pole spindle microtubule uc007kiv.1 uc007kiv.2 uc007kiv.3 uc007kiv.4 
ENSMUST00000045028.15 Crygd ENSMUST00000045028.15 crystallin, gamma D (from RefSeq NM_007776.3) CRGD_MOUSE ENSMUST00000045028.1 ENSMUST00000045028.10 ENSMUST00000045028.11 ENSMUST00000045028.12 ENSMUST00000045028.13 ENSMUST00000045028.14 ENSMUST00000045028.2 ENSMUST00000045028.3 ENSMUST00000045028.4 ENSMUST00000045028.5 ENSMUST00000045028.6 ENSMUST00000045028.7 ENSMUST00000045028.8 ENSMUST00000045028.9 NM_007776 O89027 P04342 Q6PGI0 uc007bhg.1 uc007bhg.2 uc007bhg.3 uc007bhg.4 Crystallins are the dominant structural components of the vertebrate eye lens. Detected in the superior olivary complex of the auditory hindbrain. Has a two-domain beta-structure, folded into four very similar Greek key motifs. There are six different gamma crystallins identified in mouse lens. Belongs to the beta/gamma-crystallin family. eye development lens development in camera-type eye structural constituent of eye lens nucleus cytoplasm visual perception cellular response to reactive oxygen species response to peptide hormone lens fiber cell differentiation uc007bhg.1 uc007bhg.2 uc007bhg.3 uc007bhg.4 
ENSMUST00000045035.12 Apoc1 ENSMUST00000045035.12 apolipoprotein C-I, transcript variant 2 (from RefSeq NM_001110009.2) APOC1_MOUSE ENSMUST00000045035.1 ENSMUST00000045035.10 ENSMUST00000045035.11 ENSMUST00000045035.2 ENSMUST00000045035.3 ENSMUST00000045035.4 ENSMUST00000045035.5 ENSMUST00000045035.6 ENSMUST00000045035.7 ENSMUST00000045035.8 ENSMUST00000045035.9 NM_001110009 P34928 Q505B2 uc009fmw.1 uc009fmw.2 uc009fmw.3 uc009fmw.4 uc009fmw.5 This gene encodes a precursor plasma protein that is cleaved to yield a signal peptide and two alternatively processed mature peptides. The encoded protein, which is a component of chylomicrons, very low density lipoproteins and high density lipoproteins, transports lipids from the intestines to other locations in the body. This protein binds to free fatty acids preventing their uptake by cells. This protein is a cofactor for lecithin cholesterol acyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. The encoded protein inhibits the activity of the cholesteryl ester transfer protein which promotes the exchange of neutral lipids between lipoproteins. In humans this gene is associated with risk of coronary artery disease and age-associated memory impairment. Mice lacking this gene demonstrate impaired memory. This gene is clustered with three other apolipoprotein genes on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein (By similarity). Binds free fatty acids and reduces their intracellular esterification. Secreted Adult and fetal liver. [Apolipoprotein C-I]: Mass=6993; Mass_error=0.707; Method=Electrospray; Note=Strain C57BL/6. Without methionine sulfoxide.; Evidence=; [Truncated apolipoprotein C-I]: Mass=6825.6; Mass_error=0.495; Method=Electrospray; Note=Strain C57BL/6. Without methionine sulfoxide.; Evidence=; Belongs to the apolipoprotein C1 family. phospholipase inhibitor activity fatty acid binding extracellular region endoplasmic reticulum triglyceride metabolic process lipid transport cholesterol metabolic process negative regulation of phosphatidylcholine catabolic process negative regulation of very-low-density lipoprotein particle clearance negative regulation of cholesterol transport cholesterol efflux phospholipid efflux very-low-density lipoprotein particle high-density lipoprotein particle plasma lipoprotein particle remodeling chylomicron remnant clearance very-low-density lipoprotein particle clearance lipoprotein metabolic process negative regulation of fatty acid biosynthetic process negative regulation of lipid metabolic process negative regulation of receptor-mediated endocytosis negative regulation of lipid catabolic process negative regulation of lipoprotein lipase activity lipase inhibitor activity uc009fmw.1 uc009fmw.2 uc009fmw.3 uc009fmw.4 uc009fmw.5 
ENSMUST00000045041.12 Galnt12 ENSMUST00000045041.12 polypeptide N-acetylgalactosaminyltransferase 12, transcript variant 1 (from RefSeq NM_172693.4) ENSMUST00000045041.1 ENSMUST00000045041.10 ENSMUST00000045041.11 ENSMUST00000045041.2 ENSMUST00000045041.3 ENSMUST00000045041.4 ENSMUST00000045041.5 ENSMUST00000045041.6 ENSMUST00000045041.7 ENSMUST00000045041.8 ENSMUST00000045041.9 GLT12_MOUSE NM_172693 Q8BGT9 uc008suk.1 uc008suk.2 uc008suk.3 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs (By similarity). Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Name=Functional Glycomics Gateway - GTase; Note=Polypeptide N-acetylgalactosaminyltransferase 12; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_520"; Golgi membrane molecular_function polypeptide N-acetylgalactosaminyltransferase activity Golgi apparatus protein glycosylation biological_process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups carbohydrate binding metal ion binding uc008suk.1 uc008suk.2 uc008suk.3 
ENSMUST00000045042.8 Batf2 ENSMUST00000045042.8 basic leucine zipper transcription factor, ATF-like 2, transcript variant 1 (from RefSeq NM_028967.2) BATF2_MOUSE ENSMUST00000045042.1 ENSMUST00000045042.2 ENSMUST00000045042.3 ENSMUST00000045042.4 ENSMUST00000045042.5 ENSMUST00000045042.6 ENSMUST00000045042.7 NM_028967 Q3TAI2 Q8R1H8 uc008ghq.1 uc008ghq.2 uc008ghq.3 uc008ghq.4 AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types. Possibly acts by interfering with AP-1 binding to CCN1 promoter (By similarity). Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Heterodimer; heterodimerizes with JUN family proteins. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R1H8-1; Sequence=Displayed; Name=2; IsoId=Q8R1H8-2; Sequence=VSP_025753; By cytokines in response to infection. By IFN-gamma. Mice display normal development of natural killer (NK), T- and B-cells, plasmacytoid dendritic cells (pDCs), neutrophils, resting CD8-alpha(+) classical dendritic cells (cDCs), and peritoneal, liver and lung macrophages. However, they show significantly decreased survival after infection by T.gondii. Notably, mice show significantly decreased numbers of lung-resident CD103(+)CD11b(-) dendritic cells and CD103(+)CD11b(-) macrophages after infection. Belongs to the bZIP family. RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell differentiation defense response to protozoan myeloid dendritic cell differentiation uc008ghq.1 uc008ghq.2 uc008ghq.3 uc008ghq.4 
ENSMUST00000045054.11 Tcaf1 ENSMUST00000045054.11 TRPM8 channel-associated factor 1, transcript variant 4 (from RefSeq NM_001355770.1) ENSMUST00000045054.1 ENSMUST00000045054.10 ENSMUST00000045054.2 ENSMUST00000045054.3 ENSMUST00000045054.4 ENSMUST00000045054.5 ENSMUST00000045054.6 ENSMUST00000045054.7 ENSMUST00000045054.8 ENSMUST00000045054.9 Fam115a Kiaa0738 NM_001355770 Q6A005 Q80VG2 Q8BNE1 Q8BPR4 Q8BTD3 Q8C8Q5 Q8CEM1 Q8CET9 Q8K2D7 Q9D223 TCAF1_MOUSE Tcaf1 uc009brr.1 uc009brr.2 uc009brr.3 Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner. Interacts with TRPM8 (via N-terminus and C-terminus domains); the interaction inhibits TRPM8 channel activity. Interacts with TRPV6. Cell membrane Note=Colocalizes with TRPM8 on the plasma membrane. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BNE1-1; Sequence=Displayed; Name=2; IsoId=Q8BNE1-2; Sequence=VSP_031634; Name=3; IsoId=Q8BNE1-3; Sequence=VSP_031632, VSP_031634; Name=4; IsoId=Q8BNE1-4; Sequence=VSP_031633; The C-terminal region is necessary for the channel activity stimulation. Belongs to the TCAF family. Sequence=BAD32291.1; Type=Erroneous initiation; Evidence=; plasma membrane membrane negative regulation of cell migration ion channel binding positive regulation of protein targeting to membrane positive regulation of anion channel activity uc009brr.1 uc009brr.2 uc009brr.3 
ENSMUST00000045068.10 Cplx3 ENSMUST00000045068.10 complexin 3 (from RefSeq NM_146223.3) CPLX3_MOUSE ENSMUST00000045068.1 ENSMUST00000045068.2 ENSMUST00000045068.3 ENSMUST00000045068.4 ENSMUST00000045068.5 ENSMUST00000045068.6 ENSMUST00000045068.7 ENSMUST00000045068.8 ENSMUST00000045068.9 NM_146223 Q8R1B5 Q96AW7 uc009pvg.1 uc009pvg.2 uc009pvg.3 Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (PubMed:19386896). Required for the maintenance of synaptic ultrastructure in the adult retina (PubMed:19386896). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (PubMed:15911881, PubMed:19386896, PubMed:27335398). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (PubMed:22694764, PubMed:27335398). Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A. Synapse ll membrane ; Lipid-anchor Note=Enriched at the synaptic terminal (PubMed:15911881). Localized at glycinergic synaptic contacts of AII amacrine cells with OFF cone bipolar cells in the OFF sublamina of the retina inner nuclear layer (PubMed:22694764). Present in many brain regions, including hippocampus and cerebellum (at protein level) (PubMed:15911881). Expressed in the retina (at protein level) (PubMed:15911881, PubMed:19386896). Expressed in retinal amacrine cells (at protein level) (PubMed:19386896, PubMed:22694764). Expressed in retinal photoreceptor ribbon synapses (PubMed:19386896). Expressed in the retinal inner nuclear layer, at bipolar cells (at protein level) (PubMed:22694764). Expressed in cone photoreceptor synaptic terminals (at protein level) (PubMed:22694764). In the brain, expression starts at P6 and increases to reach a plateau at P20. Farnesylation mediates presynaptic targeting. Knockout mice are generally phenotypically normal, viable, and fertile (PubMed:19386896). Normal overall retina structure and morphology of the outer plexiform layer (OPL) and inner plexiform layer (IPL) (PubMed:19386896). Abundance and distribution of synaptic proteins remain consistent (PubMed:19386896). Reduced retinal synaptic transmission and inner retinal processing (PubMed:19386896). Cplx3 and Cplx4 double knockout mice are generally phenotypically normal, viable, and fertile, however show disordered morphology of the OPL and vision perturbation when compared to single knockout mice (PubMed:19386896). Cplx3 and Cplx4 double knockout mice show evidence of mild vision perturbation, with a reduction in the number of morphologically normal anchored presynaptic ribbon synapses and a decrease in controlled neurotransmitter release at photoreceptor ribbon synapses (PubMed:19386896). Cplx3 and Cplx4 double knockout mice show reduced response and sensitivity of ON and OFF ganglion cell response as a result of disrupted synaptic transmission (PubMed:22694764). Cplx3 and Cplx4 double knockout mice show a greater variance in photoreceptor activity response and a decrease in sustained response, this is caused by an increase in release and fusion of synaptic vesicles in an asynchronous manner, this is particularly evident following multiple stimuli (PubMed:27335398). Belongs to the complexin/synaphin family. SNARE binding neurotransmitter transporter activity cytosol plasma membrane neurotransmitter transport exocytosis visual perception membrane synaptic vesicle exocytosis syntaxin binding cell junction insulin secretion SNARE complex regulation of synaptic vesicle fusion to presynaptic membrane terminal bouton synapse regulation of neurotransmitter secretion response to stimulus anchored component of synaptic vesicle membrane anchored component of presynaptic active zone membrane nucleus uc009pvg.1 uc009pvg.2 uc009pvg.3 
ENSMUST00000045075.3 Cd300ld ENSMUST00000045075.3 CD300 molecule like family member d (from RefSeq NM_145437.2) CLM5_MOUSE Cd300ld Clm5 ENSMUST00000045075.1 ENSMUST00000045075.2 Lmir4 NM_145437 Q8BRU3 Q8VCH2 uc007mgd.1 uc007mgd.2 uc007mgd.3 uc007mgd.4 uc007mgd.5 Acts as an activating receptor in myeloid cells and mast cells. (Microbial infection) Acts as a functional murine norovirus (MNV) receptor. Primary determinant of MNV species tropism and is sufficient to render cells permissive to infection by MNV. Can render nonmurine mammalian cells susceptible to MNV infection (PubMed:27681626, PubMed:27540007). Interacts with FCER1G. Cell membrane ; Single-pass type I membrane protein Expressed in dendritic cells, macrophages and granulocytes. Present on the surface of granulocytes and monocytes/macrophages (at protein level). O-glycosylated. Belongs to the CD300 family. virus receptor activity immune system process protein binding plasma membrane membrane integral component of membrane regulation of interleukin-6 production regulation of tumor necrosis factor production viral entry into host cell uc007mgd.1 uc007mgd.2 uc007mgd.3 uc007mgd.4 uc007mgd.5 
ENSMUST00000045078.13 Grhpr ENSMUST00000045078.13 glyoxylate reductase/hydroxypyruvate reductase, transcript variant 1 (from RefSeq NM_080289.2) ENSMUST00000045078.1 ENSMUST00000045078.10 ENSMUST00000045078.11 ENSMUST00000045078.12 ENSMUST00000045078.2 ENSMUST00000045078.3 ENSMUST00000045078.4 ENSMUST00000045078.5 ENSMUST00000045078.6 ENSMUST00000045078.7 ENSMUST00000045078.8 ENSMUST00000045078.9 GRHPR_MOUSE Glxr NM_080289 Q91Z53 uc008ssb.1 uc008ssb.2 uc008ssb.3 uc008ssb.4 This gene encodes a member of the D-isomer specific 2-hydroxyacid dehydrogenase family of proteins. The encoded protein catalyzes three enzymatic reactions: the conversion of hydroxypyruvate to D-glycerate as well as the reverse reaction, and the conversion of glyoxylate to glycolate. Homozygous knockout mice exhibit elevated synthesis of oxalate and glycerate. [provided by RefSeq, Aug 2015]. Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D- glycerate to hydroxypyruvate (By similarity). Reaction=glycolate + NADP(+) = glyoxylate + H(+) + NADPH; Xref=Rhea:RHEA:10992, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:36655, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.79; Reaction=(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH; Xref=Rhea:RHEA:17905, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659, ChEBI:CHEBI:17180, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.81; Reaction=(R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH; Xref=Rhea:RHEA:18657, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659, ChEBI:CHEBI:17180, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.81; Homodimer. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. cytoplasm cytosol excretion glycerate dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor hydroxypyruvate reductase activity glyoxylate reductase (NADP) activity carboxylic acid binding protein homodimerization activity dicarboxylic acid metabolic process glyoxylate metabolic process NADP binding protein oligomerization NAD binding oxidation-reduction process NADPH binding uc008ssb.1 uc008ssb.2 uc008ssb.3 uc008ssb.4 
ENSMUST00000045085.8 Grin3b ENSMUST00000045085.8 glutamate receptor, ionotropic, NMDA3B (from RefSeq NM_130455.2) ENSMUST00000045085.1 ENSMUST00000045085.2 ENSMUST00000045085.3 ENSMUST00000045085.4 ENSMUST00000045085.5 ENSMUST00000045085.6 ENSMUST00000045085.7 NMD3B_MOUSE NM_130455 Q8VHV0 Q91ZU9 uc007gau.1 uc007gau.2 uc007gau.3 NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1 and GRIN2A or GRIN2B. Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane Note=Requires the presence of GRIN1 to be targeted at the plasma membrane. Expressed in the facial nucleus and the ambiguus nucleus of the brainstem, pons, medulla, spinal cord and cerebellum. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily. ionotropic glutamate receptor activity ion channel activity cation channel activity plasma membrane ion transport glutamate receptor activity ligand-gated ion channel activity membrane integral component of membrane glycine binding NMDA selective glutamate receptor complex cell junction neurotransmitter receptor activity ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic signaling receptor activity neurotransmitter binding neuronal cell body synapse postsynaptic membrane modulation of synaptic transmission protein insertion into membrane regulation of calcium ion transport regulation of postsynaptic membrane potential calcium ion transmembrane transport cation transmembrane transport postsynaptic density membrane integral component of postsynaptic density membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential calcium channel activity uc007gau.1 uc007gau.2 uc007gau.3 
ENSMUST00000045096.6 Ppp1r3a ENSMUST00000045096.6 protein phosphatase 1, regulatory subunit 3A (from RefSeq NM_080464.2) ENSMUST00000045096.1 ENSMUST00000045096.2 ENSMUST00000045096.3 ENSMUST00000045096.4 ENSMUST00000045096.5 NM_080464 PPR3A_MOUSE Pp1g Q32MS0 Q8BUJ4 Q8BUL0 Q99MR9 uc009ayw.1 uc009ayw.2 uc009ayw.3 Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase. Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen. Membrane ; Single-pass membrane protein Skeletal muscle and heart. The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes. Phosphorylation at Ser-48 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase. protein serine/threonine phosphatase activity carbohydrate metabolic process glycogen metabolic process protein dephosphorylation membrane integral component of membrane uc009ayw.1 uc009ayw.2 uc009ayw.3 
ENSMUST00000045097.11 Gbp7 ENSMUST00000045097.11 guanylate binding protein 7, transcript variant 1 (from RefSeq NM_145545.4) ENSMUST00000045097.1 ENSMUST00000045097.10 ENSMUST00000045097.2 ENSMUST00000045097.3 ENSMUST00000045097.4 ENSMUST00000045097.5 ENSMUST00000045097.6 ENSMUST00000045097.7 ENSMUST00000045097.8 ENSMUST00000045097.9 GBP7_MOUSE Gbp4l NM_145545 Q6KAN1 Q78UK8 Q8BU48 Q91Z40 uc008rot.1 uc008rot.2 uc008rot.3 uc008rot.4 Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:18025219, PubMed:21551061, PubMed:31964735, PubMed:24739961). Hydrolyzes GTP to GMP in two consecutive cleavage reactions and predominantly uses GTP and not GDP or GMP as the substrate (PubMed:21551061, PubMed:31689351). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24739961). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24739961). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24739961). Also promotes IFN-gamma-mediated host defense against bacterial infections by regulating oxidative responses and bacteriolytic peptide generation (PubMed:21551061). May help to assemble NADPH oxidase on phagosomal membranes by acting as a bridging protein between NADPH oxidase cytosolic subunits NCF2-NCF4 and the membrane subunits CYBA-CYBB (PubMed:21551061). Participates along with GBP1 in trafficking monoubiquinated protein cargo to autolysosomes for generating ubiquitin-derived antimicrobial peptides (PubMed:21551061). Facilitates influenza A virus replication by inhibiting the activation of NF-kappaB and JAK-STAT signaling pathways and the expression of type I, type III interferons and pro-inflammatory cytokines (By similarity). Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (PubMed:18025219, PubMed:21551061, PubMed:31964735). Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite (PubMed:31964735). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Reaction=GDP + H2O = GMP + H(+) + phosphate; Xref=Rhea:RHEA:22156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22157; Evidence=; Inhibited by orthovanadate, berylium fluoride and aluminum flouride. Kinetic parameters: KM=207 uM for GTP ; Vmax=278 nmol/min/mg enzyme toward GTP ; Monomer and dimer (PubMed:31689351). Interacts with CYBA, CYBA-CYBB complex and ATG4B (PubMed:21551061). Interacts (via GB1/RHD3- type G domain) with NCF2 and NCF2-NCF4 complex (PubMed:21551061). Cytoplasmic vesicle membrane By IFNG/IFN-gamma and IFNB1/IFN-beta (PubMed:18025219). Up- regulated upon infection by T.gondii or L.monocytogenes (PubMed:18025219). Up-regulated in response to influenza virus A infection (PubMed:33408175). Mice show a dramatic susceptibility to T. gondii infection, resulting in rapid death of infected mice in the acute phase of infection. A significantly increased parasite load seen in the spleen, liver and the peritoneal fluid, with markedly elevated production of pro-inflammatory cytokines and development of severe ascites. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily. Sequence=BAC29526.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD21426.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding GTPase activity GTP binding symbiont-containing vacuole membrane cytoplasmic vesicle defense response to protozoan adhesion of symbiont to host defense response to Gram-positive bacterium cellular response to interferon-gamma uc008rot.1 uc008rot.2 uc008rot.3 uc008rot.4 
ENSMUST00000045102.7 Gipc3 ENSMUST00000045102.7 GIPC PDZ domain containing family, member 3 (from RefSeq NM_148951.3) ENSMUST00000045102.1 ENSMUST00000045102.2 ENSMUST00000045102.3 ENSMUST00000045102.4 ENSMUST00000045102.5 ENSMUST00000045102.6 GIPC3_MOUSE NM_148951 Q8R5M0 Rgs19ip3 uc007ghi.1 uc007ghi.2 uc007ghi.3 Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion. Expressed in adult lung, brain and testis. In the inner ear, it is expressed in the inner and outer hair cells of the organ of Corti. Also expressed in cochlear spiral ganglion neurons. Note=Defects in GIPC3 underlie the age-related hearing loss 5 (ahl5) and juvenile audiogenic monogenic seizure (jams1) phenotypes. Ahl5 mice show irregular structure of the stereocilia bundle of outer and inner hair cells, late-onset degeneration of the organ of Corti. The spiral ganglion exhibits a severe loss of neurons. Belongs to the GIPC family. biological_process uc007ghi.1 uc007ghi.2 uc007ghi.3 
ENSMUST00000045108.2 D1Pas1 ENSMUST00000045108.2 DNA segment, Chr 1, Pasteur Institute 1 (from RefSeq NM_033077.3) DDX3L_MOUSE ENSMUST00000045108.1 NM_033077 P16381 Pl10 uc007dzs.1 uc007dzs.2 Putative ATP-dependent RNA helicase. Possible role in a key step of the spermatogenic process. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Testis. High levels of PL10 during the meiotic and haploid stages of spermatogenesis. Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. nucleotide binding nucleic acid binding DNA binding RNA binding RNA helicase activity helicase activity ATP binding nucleus multicellular organism development gamete generation spermatogenesis hydrolase activity cell differentiation P granule uc007dzs.1 uc007dzs.2 
ENSMUST00000045110.14 Dstyk ENSMUST00000045110.14 dual serine/threonine and tyrosine protein kinase (from RefSeq NM_172516.4) DUSTY_MOUSE ENSMUST00000045110.1 ENSMUST00000045110.10 ENSMUST00000045110.11 ENSMUST00000045110.12 ENSMUST00000045110.13 ENSMUST00000045110.2 ENSMUST00000045110.3 ENSMUST00000045110.4 ENSMUST00000045110.5 ENSMUST00000045110.6 ENSMUST00000045110.7 ENSMUST00000045110.8 ENSMUST00000045110.9 NM_172516 Q3ULK4 Q5EBN5 Q6XUX1 Q8C7D4 Q8C923 Q9CTP7 Ripk5 uc007cou.1 uc007cou.2 uc007cou.3 Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1; Cytoplasm Cell membrane Apical cell membrane Basolateral cell membrane Cell junction Note=Detected in basolateral and apical membranes of all tubular epithelia. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6XUX1-1; Sequence=Displayed; Name=2; IsoId=Q6XUX1-2; Sequence=VSP_018035; Name=3; IsoId=Q6XUX1-3; Sequence=VSP_018036; Name=4; IsoId=Q6XUX1-4; Sequence=VSP_018037, VSP_018038, VSP_018039; Expressed in brain, heart, skeletal muscle, kidney and lung. Expressed in maturing tubular epithelia, with the most prominent expression in the medulla and the papilla. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells (at protein level). Widely expressed. Highly expressed in many brain regions, including in cerebellum, olfactory, hippocampus and cerebral cortex. At 14.5 dpc detected in lung and skeletal muscle, and by 18.5 dpc detected in skin, whisker, gut and testis. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Sequence=BAC34316.1; Type=Erroneous initiation; Evidence=; Sequence=BAE26444.1; Type=Erroneous initiation; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity ATP binding cytoplasm plasma membrane protein phosphorylation membrane kinase activity phosphorylation basolateral plasma membrane apical plasma membrane transferase activity peptidyl-tyrosine phosphorylation cell junction positive regulation of kinase activity negative regulation of apoptotic process cellular response to fibroblast growth factor stimulus positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of ERK1 and ERK2 cascade uc007cou.1 uc007cou.2 uc007cou.3 
ENSMUST00000045116.11 1700003F12Rik ENSMUST00000045116.11 RIKEN cDNA 1700003F12 gene (from RefSeq NM_029305.2) 1700003F12Rik ENSMUST00000045116.1 ENSMUST00000045116.10 ENSMUST00000045116.2 ENSMUST00000045116.3 ENSMUST00000045116.4 ENSMUST00000045116.5 ENSMUST00000045116.6 ENSMUST00000045116.7 ENSMUST00000045116.8 ENSMUST00000045116.9 NM_029305 Q9DAQ3 Q9DAQ3_MOUSE uc008njj.1 uc008njj.2 uc008njj.3 uc008njj.4 molecular_function cellular_component biological_process uc008njj.1 uc008njj.2 uc008njj.3 uc008njj.4 
ENSMUST00000045127.12 Wfdc5 ENSMUST00000045127.12 WAP four-disulfide core domain 5 (from RefSeq NM_145369.3) ENSMUST00000045127.1 ENSMUST00000045127.10 ENSMUST00000045127.11 ENSMUST00000045127.2 ENSMUST00000045127.3 ENSMUST00000045127.4 ENSMUST00000045127.5 ENSMUST00000045127.6 ENSMUST00000045127.7 ENSMUST00000045127.8 ENSMUST00000045127.9 NM_145369 Q4KXB6 Q4KXB6_MOUSE Wfdc5 uc008ntw.1 uc008ntw.2 uc008ntw.3 uc008ntw.4 Putative acid-stable proteinase inhibitor. molecular_function cellular_component extracellular region biological_process negative regulation of peptidase activity peptidase inhibitor activity uc008ntw.1 uc008ntw.2 uc008ntw.3 uc008ntw.4 
ENSMUST00000045138.6 Gorab ENSMUST00000045138.6 golgin, RAB6-interacting, transcript variant 1 (from RefSeq NM_178883.6) ENSMUST00000045138.1 ENSMUST00000045138.2 ENSMUST00000045138.3 ENSMUST00000045138.4 ENSMUST00000045138.5 GORAB_MOUSE NM_178883 Ntklbp1 Q8BRM2 Q8CAA8 Scyl1bp1 uc007dhl.1 uc007dhl.2 uc007dhl.3 uc007dhl.4 Interacts with RCHY1 (By similarity). Interacts with SCYL1 and RAB6A/RAB6. Cytoplasm Golgi apparatus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BRM2-1; Sequence=Displayed; Name=2; IsoId=Q8BRM2-2; Sequence=VSP_020979; Expressed in small intestine, kidney, skeletal muscle, lung, spleen, brain and heart. High expression is observed in osteoblasts and skin; also expressed in osteoclasts albeit at lower levels. Belongs to the GORAB family. protein binding nucleus nucleoplasm nucleolus cytoplasm Golgi apparatus cytosol hair follicle morphogenesis positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning non-motile cilium assembly uc007dhl.1 uc007dhl.2 uc007dhl.3 uc007dhl.4 
ENSMUST00000045142.15 Ctnnal1 ENSMUST00000045142.15 catenin alpha like 1 (from RefSeq NM_018761.3) CTNL1_MOUSE Catnal1 ENSMUST00000045142.1 ENSMUST00000045142.10 ENSMUST00000045142.11 ENSMUST00000045142.12 ENSMUST00000045142.13 ENSMUST00000045142.14 ENSMUST00000045142.2 ENSMUST00000045142.3 ENSMUST00000045142.4 ENSMUST00000045142.5 ENSMUST00000045142.6 ENSMUST00000045142.7 ENSMUST00000045142.8 ENSMUST00000045142.9 NM_018761 O88327 Q810J3 uc008sxu.1 uc008sxu.2 uc008sxu.3 uc008sxu.4 May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1). Interacts with ARHGEF1. Cytoplasm, cytoskeleton Cell membrane ; Peripheral membrane protein Belongs to the vinculin/alpha-catenin family. cytoplasm cytosol cytoskeleton plasma membrane cell adhesion Rho protein signal transduction membrane cadherin binding actin filament binding uc008sxu.1 uc008sxu.2 uc008sxu.3 uc008sxu.4 
ENSMUST00000045152.6 Taar3 ENSMUST00000045152.6 trace amine-associated receptor 3 (from RefSeq NM_001008429.1) B2RT86 ENSMUST00000045152.1 ENSMUST00000045152.2 ENSMUST00000045152.3 ENSMUST00000045152.4 ENSMUST00000045152.5 NM_001008429 Q5QD16 TAAR3_MOUSE uc007eqf.1 uc007eqf.2 Olfactory receptor activated by several primary trace amines, including isoamylamine. Activated by isoamylamine and cyclohexylamine, but not to the corresponding alcohols, isoamylalcohol and cyclohexanol. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase. Cell membrane ; Multi-pass membrane protein Specifically expressed in neurons of the olfactory epithelium. Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2- phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus G-protein coupled amine receptor activity membrane integral component of membrane uc007eqf.1 uc007eqf.2 
ENSMUST00000045153.11 Pik3ip1 ENSMUST00000045153.11 phosphoinositide-3-kinase interacting protein 1 (from RefSeq NM_178149.4) Crkd ENSMUST00000045153.1 ENSMUST00000045153.10 ENSMUST00000045153.2 ENSMUST00000045153.3 ENSMUST00000045153.4 ENSMUST00000045153.5 ENSMUST00000045153.6 ENSMUST00000045153.7 ENSMUST00000045153.8 ENSMUST00000045153.9 Hgfl NM_178149 P3IP1_MOUSE Q3TTD5 Q5NBY3 Q5NBY4 Q5NBY6 Q7TMJ8 Q811Z2 Q811Z3 uc007hsq.1 uc007hsq.2 uc007hsq.3 Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity. Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=HGFL(L); IsoId=Q7TMJ8-1; Sequence=Displayed; Name=2; Synonyms=HGFL(S); IsoId=Q7TMJ8-2; Sequence=VSP_023641, VSP_023642; Sequence=CAI35211.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAI35213.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAI35214.1; Type=Erroneous gene model prediction; Evidence=; serine-type endopeptidase activity plasma membrane proteolysis negative regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane phosphatidylinositol 3-kinase catalytic subunit binding negative regulation of phosphatidylinositol 3-kinase activity uc007hsq.1 uc007hsq.2 uc007hsq.3 
ENSMUST00000045154.6 Themis2 ENSMUST00000045154.6 thymocyte selection associated family member 2 (from RefSeq NM_001033308.2) ENSMUST00000045154.1 ENSMUST00000045154.2 ENSMUST00000045154.3 ENSMUST00000045154.4 ENSMUST00000045154.5 Icb1 NM_001033308 Q3U5K5 Q91YX0 THMS2_MOUSE Themis2 uc008vbv.1 uc008vbv.2 uc008vbv.3 May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (PubMed:27992403). Interacts with VAV1 (PubMed:20644716, PubMed:22732588). Interacts with LAT (PubMed:22732588). Interacts constitutively with GRB2, LYN and PLCG2; these interactions increase the activation of PLCG2 and its downstream pathways following B cell receptor stimulation (PubMed:27992403, PubMed:20644716, PubMed:22732588). Nucleus Cytoplasm Expressed in both developing and mature B-cells with high expression in immature, follicular and B1 B cells (PubMed:27992403, PubMed:19597499, PubMed:24907343). Also expressed in macrophages and dendritic cells (PubMed:19597499). Down-regulated in splenocytes of mice developing arthritis in a collagen-induced model, not in those of mice failing to develop the disease. Transiently down- regulated in splenocytes of mice infected with influenza virus (PubMed:19597499). Up-regulated during the differentiation of bone marrow precursors into macrophages. Up-regulated by pro-inflammatory stimuli, such as IFNG (at protein level). Down-regulated by anti-inflammatory stimuli, such as TGFB1 and dexamethasone (at protein level). Phosphorylation at Tyr-660 is induced by LPS (PubMed:20644716). Phosphorylated by Src kinases (Lck or Fyn) following BCR engagement (PubMed:20644716). Homozygous knockout mice for Themis2 are viable and produced at the expected ratio (PubMed:24907343). Mice show normal B cell development, activation, or Ab responses (PubMed:24907343). Belongs to the themis family. Sequence=AAH13712.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; immune system process protein binding nucleus cytoplasm inflammatory response T cell receptor signaling pathway uc008vbv.1 uc008vbv.2 uc008vbv.3 
ENSMUST00000045173.10 Tgfbi ENSMUST00000045173.10 transforming growth factor, beta induced, transcript variant 2 (from RefSeq NR_155548.1) BGH3_MOUSE ENSMUST00000045173.1 ENSMUST00000045173.2 ENSMUST00000045173.3 ENSMUST00000045173.4 ENSMUST00000045173.5 ENSMUST00000045173.6 ENSMUST00000045173.7 ENSMUST00000045173.8 ENSMUST00000045173.9 NR_155548 P82198 Q3U9R1 uc011zae.1 uc011zae.2 uc011zae.3 Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity). Binds to type I, II, and IV collagens. Secreted Secreted, extracellular space, extracellular matrix Note=May be associated both with microfibrils and with the cell surface. Expressed in heart, kidney, liver, skeletal muscle, testis, thyroid and uterus (PubMed:8024701). Expressed in the embryo at 12 dpc (PubMed:8024701). Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding. According to a more recent report, does not contain vitamin K-dependent gamma- carboxyglutamate residues. The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain. angiogenesis chondrocyte differentiation integrin binding extracellular matrix structural constituent collagen binding extracellular region basement membrane extracellular space trans-Golgi network cell adhesion cell proliferation extracellular matrix organization extracellular matrix cell adhesion molecule binding extracellular matrix binding uc011zae.1 uc011zae.2 uc011zae.3 
ENSMUST00000045174.7 Ypel5 ENSMUST00000045174.7 yippee like 5, transcript variant 1 (from RefSeq NM_027166.6) ENSMUST00000045174.1 ENSMUST00000045174.2 ENSMUST00000045174.3 ENSMUST00000045174.4 ENSMUST00000045174.5 ENSMUST00000045174.6 NM_027166 P62700 Q543T4 Q8R174 Q9D6M1 Q9UMX7 Q9Y3C9 YPEL5_MOUSE uc008dne.1 uc008dne.2 uc008dne.3 Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for normal cell proliferation (By similarity). Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with RANBP9 and RANBP10. Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Midbody Note=Deteted in nucleus and at the centrosome during interphase. During mitosis, detected on the mitotic spindle, at spindle poles and at the midbody. Belongs to the yippee family. ubiquitin ligase complex spindle pole molecular_function nucleus cytoplasm microtubule organizing center cytoskeleton biological_process cell proliferation midbody metal ion binding mitotic spindle pole centrosome uc008dne.1 uc008dne.2 uc008dne.3 
ENSMUST00000045196.4 Kcns1 ENSMUST00000045196.4 K+ voltage-gated channel, subfamily S, 1 (from RefSeq NM_008435.2) A2A5M1 ENSMUST00000045196.1 ENSMUST00000045196.2 ENSMUST00000045196.3 KCNS1_MOUSE NM_008435 O35173 uc008ntv.1 uc008ntv.2 Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed:9305895). Heterotetramer with KCNB1 and KCNB2 (PubMed:9305895). Does not form homomultimers (PubMed:9305895). Cell membrane ; Multi-pass membrane protein Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2 (PubMed:9305895). Detected in brain, but not in the other tissues tested. The highest levels of expression are in olfactory bulb, cerebral cortex, hippocampus, habenula, basolateral amygdaloid nuclei and cerebellum (PubMed:9305895). The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex potassium channel regulator activity membrane integral component of membrane regulation of ion transmembrane transport perinuclear region of cytoplasm protein homooligomerization transmembrane transport potassium ion transmembrane transport regulation of delayed rectifier potassium channel activity uc008ntv.1 uc008ntv.2 
ENSMUST00000045218.9 Pcm1 ENSMUST00000045218.9 pericentriolar material 1, transcript variant 4 (from RefSeq NM_023662.4) E9QLK2 ENSMUST00000045218.1 ENSMUST00000045218.2 ENSMUST00000045218.3 ENSMUST00000045218.4 ENSMUST00000045218.5 ENSMUST00000045218.6 ENSMUST00000045218.7 ENSMUST00000045218.8 NM_023662 O70287 PCM1_MOUSE Pcm1 Q3URH6 Q7TMS7 Q8C9V2 Q91Y27 Q91Y28 Q91Y51 Q923L0 Q9CRK8 Q9CT57 Q9R0L6 uc009lnr.1 uc009lnr.2 uc009lnr.3 uc009lnr.4 Required for centrosome assembly and function (PubMed:12112146). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (By similarity). Required to anchor microtubules to the centrosome (By similarity). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:27979967). Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites (By similarity). Self-associates. Interacts with BBS4, BBS8, CETN3, HAP1, NDE1, NDEL1, MAP1LC3B, GABARAPAL2, and GABARAP. Interacts with CEP131; the interaction increases in response to ultraviolet light (UV) radiation. Associates with microtubule; association to microtubule is reduced in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling (By similarity). Interacts with C2CD3 (PubMed:24469809). Interacts with CCDC113 (By similarity). Interacts with SSX2IP (PubMed:24356449). Interacts with CCDC13 (By similarity). Interacts with CEP290 (PubMed:17705300). Interacts with PARD6A (By similarity). Interacts with KIAA0753/OFIP, CEP20/FOR20 and OFD1; the interaction with CEP20/FOR20 and OFD1 may be mediated by KIAA0753/OFIP (PubMed:26643951). Interacts with CCDC66 (By similarity). Interacts with CCDC61 (By similarity). Interacts with DZIP1; localizes DZIP1 and the associated BBSome to centriolar satellite (PubMed:27979967). Interacts with CSTPP1, TTLL1, TPGS1 and LRRC49 (By similarity). Q9R0L6; Q6A078: Cep290; NbExp=4; IntAct=EBI-4284371, EBI-1811999; Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome toplasmic granule Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite toplasm, cytoskeleton, cilium basal body Note=Recruitment to the centrosome requires microtubules and dynein. Displaced from centriolar satellites and centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling (By similarity). The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9R0L6-1; Sequence=Displayed; Name=2; IsoId=Q9R0L6-2; Sequence=VSP_022612; Expressed in the hippocampus and dentate gyrus, the columnar epithelial cells of bronchioles, the olfactory epithelium, the pericardium and the inner segment of the retina. Maternally derived during fertilization. Expressed in the pericardium of the developing embryo and in the epidermal layer surrounding the digits. Ubiquitinated. Undergoes monoubiquitination catalyzed by the E3 ubiquitin-protein ligase MIB1 in proliferating cells, preventing cilia formation. Monoubiquitination by MIB1 is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, resulting in cilia formation initiation. Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown. Phosphorylation by DYRK3 promotes disassembly of pericentriolar material (By similarity). Phosphorylation at Ser-372 mediated by PLK4 is required to maintain the integrity of centriolar satellites (By similarity). Belongs to the PCM1 family. pericentriolar material neuron migration protein binding cytoplasm centrosome centriole microtubule organizing center cytosol cytoskeleton centrosome cycle interkinetic nuclear migration cell projection organization cytoplasmic microtubule organization nuclear membrane macromolecular complex protein localization to organelle centriolar satellite microtubule anchoring microtubule anchoring at centrosome social behavior intraciliary transport involved in cilium assembly ciliary transition zone ciliary basal body cell projection apical part of cell negative regulation of neurogenesis cilium assembly protein localization to centrosome positive regulation of intracellular protein transport neuronal stem cell population maintenance non-motile cilium assembly uc009lnr.1 uc009lnr.2 uc009lnr.3 uc009lnr.4 
ENSMUST00000045224.14 Acer2 ENSMUST00000045224.14 alkaline ceramidase 2, transcript variant 1 (from RefSeq NM_139306.3) ACER2_MOUSE Acer2 Asah3l ENSMUST00000045224.1 ENSMUST00000045224.10 ENSMUST00000045224.11 ENSMUST00000045224.12 ENSMUST00000045224.13 ENSMUST00000045224.2 ENSMUST00000045224.3 ENSMUST00000045224.4 ENSMUST00000045224.5 ENSMUST00000045224.6 ENSMUST00000045224.7 ENSMUST00000045224.8 ENSMUST00000045224.9 NM_139306 Q6PB92 Q8BUG3 Q8VD53 uc008tmf.1 uc008tmf.2 uc008tmf.3 uc008tmf.4 uc008tmf.5 Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:29401619). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:29401619). Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (By similarity) (PubMed:29401619). Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates. Also hydrolyzes dihydroceramides to produce dihydrosphingosine (By similarity). It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (PubMed:29401619). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate. As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage. Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (By similarity). Reaction=an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine; Xref=Rhea:RHEA:20856, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868, ChEBI:CHEBI:52639, ChEBI:CHEBI:57756; EC=3.5.1.23; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20857; Evidence=; Reaction=H2O + N-(15Z-tetracosenoyl)-sphing-4-enine = (15Z)- tetracosenoate + sphing-4-enine; Xref=Rhea:RHEA:41267, ChEBI:CHEBI:15377, ChEBI:CHEBI:32392, ChEBI:CHEBI:57756, ChEBI:CHEBI:74450; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41268; Evidence=; Reaction=H2O + N-eicosanoyl-sphing-4-enine = eicosanoate + sphing-4- enine; Xref=Rhea:RHEA:41275, ChEBI:CHEBI:15377, ChEBI:CHEBI:32360, ChEBI:CHEBI:57756, ChEBI:CHEBI:72962; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41276; Evidence=; Reaction=H2O + N-octadecanoylsphing-4-enine = octadecanoate + sphing-4- enine; Xref=Rhea:RHEA:41279, ChEBI:CHEBI:15377, ChEBI:CHEBI:25629, ChEBI:CHEBI:57756, ChEBI:CHEBI:72961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41280; Evidence=; Reaction=H2O + N-hexadecanoylsphing-4-enine = hexadecanoate + sphing-4- enine; Xref=Rhea:RHEA:38891, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:57756, ChEBI:CHEBI:72959; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38892; Evidence=; Reaction=H2O + N-tetradecanoylsphing-4-enine = sphing-4-enine + tetradecanoate; Xref=Rhea:RHEA:41287, ChEBI:CHEBI:15377, ChEBI:CHEBI:30807, ChEBI:CHEBI:57756, ChEBI:CHEBI:72957; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41288; Evidence=; Reaction=H2O + N-dodecanoylsphing-4-enine = dodecanoate + sphing-4- enine; Xref=Rhea:RHEA:41291, ChEBI:CHEBI:15377, ChEBI:CHEBI:18262, ChEBI:CHEBI:57756, ChEBI:CHEBI:72956; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41292; Evidence=; Reaction=H2O + N-tetracosanoyl-sphing-4-enine = sphing-4-enine + tetracosanoate; Xref=Rhea:RHEA:41283, ChEBI:CHEBI:15377, ChEBI:CHEBI:31014, ChEBI:CHEBI:57756, ChEBI:CHEBI:72965; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41284; Evidence=; Reaction=H2O + N-(hexanoyl)sphing-4-enine = hexanoate + sphing-4-enine; Xref=Rhea:RHEA:41295, ChEBI:CHEBI:15377, ChEBI:CHEBI:17120, ChEBI:CHEBI:57756, ChEBI:CHEBI:63867; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41296; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-sphing-4-enine = (9Z)-octadecenoate + sphing-4-enine; Xref=Rhea:RHEA:41299, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57756, ChEBI:CHEBI:77996; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41300; Evidence=; Reaction=an N-acylsphinganine + H2O = a fatty acid + sphinganine; Xref=Rhea:RHEA:33551, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868, ChEBI:CHEBI:31488, ChEBI:CHEBI:57817; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33552; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Lipid metabolism; sphingolipid metabolism. Golgi apparatus membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VD53-1; Sequence=Displayed; Name=2; IsoId=Q8VD53-2; Sequence=VSP_020036; Widely expressed with higher expression in lung. Homozygous knockout mice display no overt phenotype (PubMed:29401619). Reduced levels of sphingosine, dihydrosphingosine, sphingosine-1-phosphate and dihydrosphingosine -1- phosphate are observed in plasma, erythrocytes and platelets (PubMed:29401619). Belongs to the alkaline ceramidase family. Sequence=BAC39416.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence=; Golgi membrane negative regulation of cell-matrix adhesion Golgi apparatus lipid metabolic process sphingolipid metabolic process ceramide metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus positive regulation of cell proliferation regulation of autophagy positive regulation of cell death membrane integral component of membrane hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ceramidase activity integral component of Golgi membrane DNA damage response, signal transduction by p53 class mediator response to retinoic acid negative regulation of cell adhesion mediated by integrin cellular response to drug regulation of apoptotic process sphingosine biosynthetic process ceramide catabolic process metal ion binding dihydroceramidase activity negative regulation of protein glycosylation in Golgi uc008tmf.1 uc008tmf.2 uc008tmf.3 uc008tmf.4 uc008tmf.5 
ENSMUST00000045228.12 Zkscan8 ENSMUST00000045228.12 zinc finger with KRAB and SCAN domains 8, transcript variant 1 (from RefSeq NM_139141.4) ENSMUST00000045228.1 ENSMUST00000045228.10 ENSMUST00000045228.11 ENSMUST00000045228.2 ENSMUST00000045228.3 ENSMUST00000045228.4 ENSMUST00000045228.5 ENSMUST00000045228.6 ENSMUST00000045228.7 ENSMUST00000045228.8 ENSMUST00000045228.9 NM_139141 Q8BSL0 Q8BSL0_MOUSE Zfp192 Zkscan8 uc007pqr.1 uc007pqr.2 uc007pqr.3 uc007pqr.4 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc007pqr.1 uc007pqr.2 uc007pqr.3 uc007pqr.4 
ENSMUST00000045229.7 Tmco3 ENSMUST00000045229.7 transmembrane and coiled-coil domains 3, transcript variant 1 (from RefSeq NM_172282.2) ENSMUST00000045229.1 ENSMUST00000045229.2 ENSMUST00000045229.3 ENSMUST00000045229.4 ENSMUST00000045229.5 ENSMUST00000045229.6 NM_172282 Q3UFX1 Q7TMT5 Q8BGL4 Q8BH01 Q8R303 TMCO3_MOUSE uc009kxn.1 uc009kxn.2 uc009kxn.3 Probable Na(+)/H(+) antiporter. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BH01-1; Sequence=Displayed; Name=2; IsoId=Q8BH01-2; Sequence=VSP_020567; Name=3; IsoId=Q8BH01-3; Sequence=VSP_020565, VSP_020566; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. ion transport cation transport biological_process antiporter activity solute:proton antiporter activity membrane integral component of membrane transmembrane transport hydrogen ion transmembrane transport uc009kxn.1 uc009kxn.2 uc009kxn.3 
ENSMUST00000045235.8 Bmt2 ENSMUST00000045235.8 base methyltransferase of 25S rRNA 2 (from RefSeq NM_175312.4) A6H608 Bmt2 ENSMUST00000045235.1 ENSMUST00000045235.2 ENSMUST00000045235.3 ENSMUST00000045235.4 ENSMUST00000045235.5 ENSMUST00000045235.6 ENSMUST00000045235.7 NM_175312 Q8BXK4 SAMTR_MOUSE Samtor uc012eic.1 uc012eic.2 uc012eic.3 S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L- methionine-dependent methyltransferase. Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S- adenosyl-L-methionine. Belongs to the BMT2 family. Sequence=BAC32852.1; Type=Frameshift; Evidence=; nucleolus methyltransferase activity rRNA (adenine) methyltransferase activity transferase activity rRNA methylation methylation cellular response to amino acid starvation S-adenosyl-L-methionine binding negative regulation of TORC1 signaling Iml1 complex uc012eic.1 uc012eic.2 uc012eic.3 
ENSMUST00000045246.8 Pkn3 ENSMUST00000045246.8 protein kinase N3 (from RefSeq NM_153805.2) ENSMUST00000045246.1 ENSMUST00000045246.2 ENSMUST00000045246.3 ENSMUST00000045246.4 ENSMUST00000045246.5 ENSMUST00000045246.6 ENSMUST00000045246.7 NM_153805 PKN3_MOUSE Pknbeta Q8K045 uc008jbb.1 uc008jbb.2 uc008jbb.3 Contributes to invasiveness in malignant prostate cancer. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Two specific sites, Thr-707 (activation loop of the kinase domain) and Thr-849 (turn motif), need to be phosphorylated for its full activation. Nucleus Cytoplasm, perinuclear region Note=Nuclear and perinuclear Golgi region. The C1 domain does not bind the diacylglycerol (DAG). Autophosphorylated. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity ATP binding nucleus cytoplasm protein phosphorylation signal transduction epithelial cell migration kinase activity phosphorylation transferase activity GTP-Rho binding peptidyl-serine phosphorylation intracellular signal transduction perinuclear region of cytoplasm uc008jbb.1 uc008jbb.2 uc008jbb.3 
ENSMUST00000045247.9 Wdr18 ENSMUST00000045247.9 WD repeat domain 18, transcript variant 2 (from RefSeq NR_184850.1) ENSMUST00000045247.1 ENSMUST00000045247.2 ENSMUST00000045247.3 ENSMUST00000045247.4 ENSMUST00000045247.5 ENSMUST00000045247.6 ENSMUST00000045247.7 ENSMUST00000045247.8 NR_184850 Q4VBE8 WDR18_MOUSE uc007gat.1 uc007gat.2 uc007gat.3 Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). May play a role during development (By similarity). Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9 (PubMed:22872859). Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles (By similarity). Nucleus, nucleolus Nucleus, nucleoplasm Cytoplasm Dynein axonemal particle Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. Belongs to the WD repeat IPI3/WDR18 family. molecular_function nucleus nucleoplasm nuclear pre-replicative complex nucleolus cytoplasm rRNA processing multicellular organism development regulation of DNA-dependent DNA replication initiation Rix1 complex uc007gat.1 uc007gat.2 uc007gat.3 
ENSMUST00000045262.11 Ak5 ENSMUST00000045262.11 adenylate kinase 5, transcript variant 10 (from RefSeq NM_001409744.1) ENSMUST00000045262.1 ENSMUST00000045262.10 ENSMUST00000045262.2 ENSMUST00000045262.3 ENSMUST00000045262.4 ENSMUST00000045262.5 ENSMUST00000045262.6 ENSMUST00000045262.7 ENSMUST00000045262.8 ENSMUST00000045262.9 KAD5_MOUSE NM_001409744 Q920P5 uc008rtq.1 uc008rtq.2 uc008rtq.3 Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3; Evidence=; Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Monomer. Interacts with YWHAZ (PubMed:16959763). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q920P5-1; Sequence=Displayed; Name=2; IsoId=Q920P5-2; Sequence=VSP_037880; Brain specific. Belongs to the adenylate kinase family. nucleotide binding adenylate kinase activity nucleoside diphosphate kinase activity ATP binding cytoplasm microtubule organizing center cytosol nucleobase-containing compound metabolic process nucleoside diphosphate phosphorylation nucleoside triphosphate biosynthetic process kinase activity phosphorylation transferase activity nucleobase-containing compound kinase activity ATP metabolic process nucleoside monophosphate phosphorylation uc008rtq.1 uc008rtq.2 uc008rtq.3 
ENSMUST00000045270.15 Cbfa2t2 ENSMUST00000045270.15 CBFA2/RUNX1 translocation partner 2, transcript variant 1 (from RefSeq NM_172860.2) B2RRH8 Cbfa2t2h ENSMUST00000045270.1 ENSMUST00000045270.10 ENSMUST00000045270.11 ENSMUST00000045270.12 ENSMUST00000045270.13 ENSMUST00000045270.14 ENSMUST00000045270.2 ENSMUST00000045270.3 ENSMUST00000045270.4 ENSMUST00000045270.5 ENSMUST00000045270.6 ENSMUST00000045270.7 ENSMUST00000045270.8 ENSMUST00000045270.9 MTG8R_MOUSE Mtgr1 NM_172860 O70374 Q30BK8 Q6P288 uc008njf.1 uc008njf.2 uc008njf.3 uc008njf.4 Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation (PubMed:27281218). Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent mannerCan repress the expression of MMP7 in a ZBTB33-dependent manner (By similarity). Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:19799863). Required for the maintenance of the secretory cell lineage in the small intestine (PubMed:16227606). Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (PubMed:25398765). Homooligomer. Homotetramerization is mediated by the NHR2 domain. Interacts with CBFA2T3/MTG16 (PubMed:19799863). Can interact with RUNX1T1/CBFA2T1. Heterotetramerization between members of the CBFA2T family is proposed (By similarity). Interacts with RBP, GFI1, TCF4, PRDM14 (PubMed:25398765, PubMed:18039847, PubMed:27281218). Interacts with TAL1 and CBFA2T3/MTG16; the heteromer with CBFA2T3/MTG16 may function in repression of TAL1 (PubMed:19799863). O70374; P22091: Tal1; NbExp=8; IntAct=EBI-8006755, EBI-8006437; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O70374-1; Sequence=Displayed; Name=2; IsoId=O70374-2; Sequence=VSP_030517; Expressed in embryonic stem cells. First expression detected on embryonic day 11.5. Nervy homology region 2 (NHR2) mediates homo- and possibly heterotypic oligomerization by forming a four-helix bundle tetrameric structure. Note=Required for tumorigenesis in a AOM/DSS colitis- associated carcinoma model. May be involved in intestinal tumorigenesis. Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine. Belongs to the CBFA2T family. negative regulation of transcription from RNA polymerase II promoter transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus regulation of transcription, DNA-templated positive regulation of neuron projection development negative regulation of neuron projection development epithelial cell differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated metal ion binding intestinal epithelial cell differentiation uc008njf.1 uc008njf.2 uc008njf.3 uc008njf.4 
ENSMUST00000045281.13 Smg6 ENSMUST00000045281.13 SMG6 nonsense mediated mRNA decay factor (from RefSeq NM_001002764.2) ENSMUST00000045281.1 ENSMUST00000045281.10 ENSMUST00000045281.11 ENSMUST00000045281.12 ENSMUST00000045281.2 ENSMUST00000045281.3 ENSMUST00000045281.4 ENSMUST00000045281.5 ENSMUST00000045281.6 ENSMUST00000045281.7 ENSMUST00000045281.8 ENSMUST00000045281.9 EST1A_MOUSE Est1a Kiaa0732 NM_001002764 P61406 Q5NC64 Smg6 uc007kcz.1 uc007kcz.2 uc007kcz.3 Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA. Name=Mn(2+); Xref=ChEBI:CHEBI:29035; May form homooligomers. Associated component of the telomerase holoenzyme complex. Interacts with TERT, independently of the telomerase RNA. Interacts with SMG1, SMG5, SMG7, UPF1, UPF2, UPF3B and the PP2A catalytic subunits. Also interacts with the exon junction complex (EJC) composed at least of CASC3, EIF4A3, MAGOH and RBM8A; required for the process of nonsense-mediated mRNA decay. Interacts with DHX34; the interaction is RNA-independent (By similarity). Nucleus, nucleolus Chromosome, telomere Cytoplasm, cytosol Note=Particularly enriched in the nucleolus. The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay chromosome, telomeric region DNA binding RNA binding nuclease activity endonuclease activity endoribonuclease activity nucleus chromosome telomerase holoenzyme complex nucleolus cytoplasm cytosol telomere maintenance via telomerase hydrolase activity regulation of telomere maintenance regulation of telomere maintenance via telomerase exon-exon junction complex telomeric DNA binding ribonucleoprotein complex binding metal ion binding telomerase RNA binding DNA polymerase binding nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic negative regulation of telomere capping uc007kcz.1 uc007kcz.2 uc007kcz.3 
ENSMUST00000045286.9 Tmem59l ENSMUST00000045286.9 transmembrane protein 59-like, transcript variant 1 (from RefSeq NM_182991.3) Bsmap ENSMUST00000045286.1 ENSMUST00000045286.2 ENSMUST00000045286.3 ENSMUST00000045286.4 ENSMUST00000045286.5 ENSMUST00000045286.6 ENSMUST00000045286.7 ENSMUST00000045286.8 NM_182991 Q7TNI2 TM59L_MOUSE uc009mai.1 uc009mai.2 uc009mai.3 Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding (By similarity). Golgi apparatus membrane ; Single- pass type I membrane protein Belongs to the TMEM59 family. Golgi membrane molecular_function cellular_component Golgi apparatus biological_process membrane integral component of membrane uc009mai.1 uc009mai.2 uc009mai.3 
ENSMUST00000045288.14 Tgfb2 ENSMUST00000045288.14 transforming growth factor, beta 2, transcript variant 1 (from RefSeq NM_009367.4) ENSMUST00000045288.1 ENSMUST00000045288.10 ENSMUST00000045288.11 ENSMUST00000045288.12 ENSMUST00000045288.13 ENSMUST00000045288.2 ENSMUST00000045288.3 ENSMUST00000045288.4 ENSMUST00000045288.5 ENSMUST00000045288.6 ENSMUST00000045288.7 ENSMUST00000045288.8 ENSMUST00000045288.9 NM_009367 P27090 Q91VP5 TGFB2_MOUSE uc007dzo.1 uc007dzo.2 uc007dzo.3 uc007dzo.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Mice lacking a functional copy of this gene display developmental defects in multiple organs and perinatal lethality. Heterozygous mutant mice exhibit aortic root aneurysm. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]. [Transforming growth factor beta-2 proprotein]: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. [Latency-associated peptide]: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2. [Transforming growth factor beta-2]: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). Interacts with the serine proteases, HTRA1 and HTRA3 (PubMed:15206957, PubMed:14973287). Interacts with ASPN (By similarity). Interacts with MFAP5 (PubMed:23963447). [Latency-associated peptide]: Interacts with Transforming growth factor beta-2 (TGF-beta-2) chain; interaction is non-covalent and maintains (TGF-beta-2) in a latent state (By similarity). Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-2 (By similarity). Interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction (PubMed:14985127). [Transforming growth factor beta-2]: Transforming growth factor beta-2: Homodimer; disulfide-linked (By similarity). Transforming growth factor beta-2: Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity). [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix [Transforming growth factor beta-2]: Secreted [Transforming growth factor beta-2]: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta- 2 (TGF-beta-2) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-2 inactive. Belongs to the TGF-beta family. cell morphogenesis skeletal system development cartilage condensation beta-amyloid binding blood vessel development eye development response to hypoxia kidney development epithelial to mesenchymal transition neural tube closure hair follicle development blood vessel remodeling heart morphogenesis outflow tract septum morphogenesis membranous septum morphogenesis outflow tract morphogenesis heart valve morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis endocardial cushion morphogenesis cardiac left ventricle morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis endocardial cushion fusion atrial septum primum morphogenesis neural retina development receptor binding type II transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding protein binding extracellular region basement membrane extracellular space cytoplasm endosome trans-Golgi network protein phosphorylation cell cycle arrest transforming growth factor beta receptor signaling pathway axon guidance salivary gland morphogenesis heart development growth factor activity cell death positive regulation of cell proliferation negative regulation of cell proliferation glial cell migration male gonad development response to wounding cell surface cardioblast differentiation positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration negative regulation of alkaline phosphatase activity positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of macrophage cytokine production positive regulation of phosphatidylinositol 3-kinase signaling cell migration negative regulation of angiogenesis hemopoiesis secretory granule extracellular matrix organization collagen fibril organization positive regulation of cell growth negative regulation of cell growth embryonic limb morphogenesis positive regulation of cell migration axon BMP signaling pathway neutrophil chemotaxis extracellular matrix hair follicle morphogenesis activation of protein kinase activity response to progesterone positive regulation of stress-activated MAPK cascade regulation of transforming growth factor beta2 production regulation of actin cytoskeleton organization positive regulation of cell adhesion mediated by integrin type III transforming growth factor beta receptor binding ascending aorta morphogenesis wound healing regulation of cell proliferation dopamine biosynthetic process response to drug protein homodimerization activity regulation of apoptotic process neuronal cell body positive regulation of apoptotic process negative regulation of apoptotic process regulation of MAPK cascade positive regulation of neuron apoptotic process response to estrogen cell-cell junction organization negative regulation of keratinocyte differentiation positive regulation of integrin biosynthetic process positive regulation of Notch signaling pathway positive regulation of ossification positive regulation of cell cycle positive regulation of heart contraction negative regulation of Ras protein signal transduction protein heterodimerization activity protein N-terminus binding somatic stem cell division cell development embryonic digestive tract development neuron fate commitment neuron development embryonic neurocranium morphogenesis inner ear development negative regulation of epithelial cell proliferation positive regulation of protein secretion negative regulation of immune response positive regulation of immune response negative regulation of release of sequestered calcium ion into cytosol positive regulation of cell division regulation of catagen positive regulation of catagen positive regulation of cardioblast differentiation cardiac muscle cell proliferation uterus development cardiac epithelial to mesenchymal transition face morphogenesis pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction ventricular septum morphogenesis atrial septum morphogenesis negative regulation of cartilage development pharyngeal arch artery morphogenesis positive regulation of activation-induced cell death of T cells positive regulation of extracellular matrix disassembly extrinsic apoptotic signaling pathway positive regulation of protein localization to nucleus regulation of apoptotic process involved in outflow tract morphogenesis positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of extracellular matrix organization substantia propria of cornea development positive regulation of GTP binding cranial skeletal system development negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of extrinsic apoptotic signaling pathway in absence of ligand uc007dzo.1 uc007dzo.2 uc007dzo.3 uc007dzo.4 
ENSMUST00000045289.6 Pnpla3 ENSMUST00000045289.6 patatin-like phospholipase domain containing 3, transcript variant 7 (from RefSeq NR_176646.1) E9QNZ9 E9QNZ9_MOUSE ENSMUST00000045289.1 ENSMUST00000045289.2 ENSMUST00000045289.3 ENSMUST00000045289.4 ENSMUST00000045289.5 NR_176646 Pnpla3 uc007xbw.1 uc007xbw.2 uc007xbw.3 long-chain fatty acid metabolic process 1-acylglycerol-3-phosphate O-acyltransferase activity phospholipase A2 activity triglyceride lipase activity lipid particle lipid metabolic process glycerophospholipid metabolic process phosphatidic acid biosynthetic process membrane integral component of membrane lipid catabolic process hydrolase activity triglyceride biosynthetic process triglyceride catabolic process lipid particle organization lysophosphatidic acid binding long-chain fatty acyl-CoA binding triglyceride acyl-chain remodeling lysophosphatidic acid acyltransferase activity mono-olein transacylation activity diolein transacylation activity uc007xbw.1 uc007xbw.2 uc007xbw.3 
ENSMUST00000045291.14 Kmt2c ENSMUST00000045291.14 lysine (K)-specific methyltransferase 2C (from RefSeq NM_001081383.2) ENSMUST00000045291.1 ENSMUST00000045291.10 ENSMUST00000045291.11 ENSMUST00000045291.12 ENSMUST00000045291.13 ENSMUST00000045291.2 ENSMUST00000045291.3 ENSMUST00000045291.4 ENSMUST00000045291.5 ENSMUST00000045291.6 ENSMUST00000045291.7 ENSMUST00000045291.8 ENSMUST00000045291.9 F8WI37 F8WI37_MOUSE Kmt2c Mll3 NM_001081383 uc008wsv.1 uc008wsv.2 uc008wsv.3 Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265; Evidence=; Nucleus nucleus regulation of transcription, DNA-templated histone-lysine N-methyltransferase activity histone lysine methylation histone methyltransferase complex histone methyltransferase activity (H3-K4 specific) MLL3/4 complex metal ion binding histone H3-K4 methylation uc008wsv.1 uc008wsv.2 uc008wsv.3 
ENSMUST00000045295.14 Pnpla7 ENSMUST00000045295.14 patatin-like phospholipase domain containing 7 (from RefSeq NM_146251.4) A2AJ88 A9YTK0 B0LS74 B0ZTC6 B9EJ75 ENSMUST00000045295.1 ENSMUST00000045295.10 ENSMUST00000045295.11 ENSMUST00000045295.12 ENSMUST00000045295.13 ENSMUST00000045295.2 ENSMUST00000045295.3 ENSMUST00000045295.4 ENSMUST00000045295.5 ENSMUST00000045295.6 ENSMUST00000045295.7 ENSMUST00000045295.8 ENSMUST00000045295.9 NM_146251 PLPL7_MOUSE Q3TD21 Q3UFP1 Q66JS2 Q6P3F9 Q8BTY7 Q8R064 Q8R3C5 uc008ipw.1 uc008ipw.2 uc008ipw.3 uc008ipw.4 Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine (PubMed:18086666, PubMed:28887301). Can also deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0) (PubMed:22326266, PubMed:18086666, PubMed:28887301). [Isoform 2]: Lysophospholipase. [Isoform 3]: Lacks lysophospholipase activity. Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15178; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)- octadecenoate + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40807, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28610, ChEBI:CHEBI:30823; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40808; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:40895, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74971, ChEBI:CHEBI:143890; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40896; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine; Xref=Rhea:RHEA:40499, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:64765, ChEBI:CHEBI:74617; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40500; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphate + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:49092, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57518, ChEBI:CHEBI:57597; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49093; Evidence=; cAMP does not regulate lysophospholipase activity in vitro (PubMed:18086666, PubMed:28887301). Slightly inhibited by organophosphorus (OP) compounds such as mipafox, which is likely why mice are less sensitive to distal axonophathy induced by OPs compared to humans (PubMed:18086666). pH dependence: Optimum pH is 8.5. ; Endoplasmic reticulum membrane ; Single-pass type III membrane protein Lipid droplet [Isoform 1]: Endoplasmic reticulum membrane ; Single-pass type III membrane protein [Isoform 2]: Endoplasmic reticulum membrane ; Single-pass type III membrane protein [Isoform 3]: Endoplasmic reticulum membrane ; Single-pass type III membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AJ88-1; Sequence=Displayed; Name=2; Synonyms=mNREV1 ; IsoId=A2AJ88-2; Sequence=VSP_026506, VSP_026507; Name=3; Synonyms=mNREV2 ; IsoId=A2AJ88-3; Sequence=VSP_053967, VSP_053968; [Isoform 1]: Expressed in white and brown adipose tissue, cardiac muscle, skeletal muscle, and testis. [Isoform 2]: Expressed in white adipose tissue, cardiac muscle, skeletal muscle, and testis. [Isoform 3]: Expressed in white adipose tissue, cardiac muscle, skeletal muscle, and testis. By nutritional conditions (PubMed:22326266, PubMed:18086666). Expression of isoform 3 is switched to the expression of isoform 2 during fasting (PubMed:22326266). [Isoform 1]: Expression levels are not affected by fasting. [Isoform 2]: In white adipose tissue, cardiac muscle, skeletal muscle, and testis, expression levels are down-regulated under well-fed conditions and are up-regulated during fasting. [Isoform 3]: In white adipose tissue, cardiac muscle, skeletal muscle, and testis, expression levels are up-regulated under well-fed conditions and are down-regulated during fasting. The 3 cNMP binding domains are required for localization to the endoplasmic reticulum (PubMed:28887301). The cNMP binding domain 3 is involved in the binding to lipid droplets (PubMed:28887301). Belongs to the NTE family. It is uncertain whether Met-1 or Met-27 is the initiator. Sequence=AAH27342.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH27342.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=AAI41366.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI41367.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC40302.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE28519.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE41783.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; lysophospholipase activity nucleus mitochondrion lysosome lysosomal membrane endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process membrane integral component of membrane lipid catabolic process hydrolase activity organelle membrane nuclear membrane mitochondrial membrane intracellular membrane-bounded organelle carboxylic ester hydrolase activity uc008ipw.1 uc008ipw.2 uc008ipw.3 uc008ipw.4 
ENSMUST00000045296.6 Siah1a ENSMUST00000045296.6 siah E3 ubiquitin protein ligase 1A (from RefSeq NM_009172.2) ENSMUST00000045296.1 ENSMUST00000045296.2 ENSMUST00000045296.3 ENSMUST00000045296.4 ENSMUST00000045296.5 NM_009172 P61092 Q06984 SIA1A_MOUSE uc009mqn.1 uc009mqn.2 uc009mqn.3 uc009mqn.4 uc009mqn.5 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin- mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2 (By similarity). Required for completion of meiosis I in males (PubMed:11884614). Induces apoptosis in cooperation with PEG3 (PubMed:10681424). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (PubMed:24809345). Also part of the Wnt signaling pathway in which it mediates the Wnt- induced ubiquitin-mediated proteasomal degradation of AXIN1. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homodimer. Component of some large E3 complex composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with UBE2I. Interacts with alpha-tubulin. Interacts with PEG10, which may inhibit its activity. Interacts with PEG3 (By similarity). Interacts with group 1 glutamate receptors GRM1 and GRM5. Interacts with DAB1, which may inhibit its activity. Interacts with UBE2E2. Interacts with SNCAIP. Interacts with KHDRBS3. Interacts with SNCAIP. Interacts with HIPK2; the interaction is promoted by DAZAP2 and results in SIAH1-mediated ubiquitination and subsequent proteasomal degradation of HIPK2 (By similarity). Interacts with DAZAP2; the interaction is decreased following phosphorylation of DAZAP2 by HIPK2 (By similarity). Interacts with GAPDH; leading to stabilize SIAH1. Interacts with Bassoon/BSN and Piccolo/PLCO; these interactions negatively regulate SIAH1 E3 ligase activity. Interacts with DCC (By similarity). Interacts with AXIN1; catalyzes AXIN1 ubiquitination and subsequent proteasome-mediated ubiquitin-dependent degradation. P61092; P97318: Dab1; NbExp=3; IntAct=EBI-446761, EBI-81680; P61092; Q27934: phyl; Xeno; NbExp=2; IntAct=EBI-446761, EBI-77033; Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. Widely expressed at low level in embryos and adults. Expressed at higher level in testis. Due to the high similarity between SIAH1A and SIAH1B, it is difficult to distinguish its own tissue specificity. May be induced by p53/TP53, suggesting that it may be required to modulate p53/TP53 response (PubMed:12417719). The relevance of such activity in vivo is however unclear and may not exist (PubMed:12417719). Induced by ATF4 in response to the unfolded protein response (UPR) (PubMed:24809345). The RING-type zinc finger domain is essential for ubiquitin ligase activity. The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family. Phosphorylated on Ser-19 by ATM and ATR. This phosphorylation disrupts SIAH1 interaction with HIPK2, and subsequent proteasomal degradation of HIPK2 (By similarity). Belongs to the SINA (Seven in absentia) family. ubiquitin-protein transferase activity protein binding nucleus cytoplasm early endosome cytosol plasma membrane ubiquitin-dependent protein catabolic process apoptotic process cell cycle male meiosis I multicellular organism development spermatogenesis protein C-terminus binding zinc ion binding post-embryonic development protein ubiquitination transferase activity SCF ubiquitin ligase complex cell differentiation protein catabolic process beta-catenin destruction complex ubiquitin conjugating enzyme binding protein destabilization regulation of multicellular organism growth identical protein binding protein homodimerization activity positive regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding neuron apoptotic process ubiquitin protein ligase activity disordered domain specific binding positive regulation of intrinsic apoptotic signaling pathway uc009mqn.1 uc009mqn.2 uc009mqn.3 uc009mqn.4 uc009mqn.5 
ENSMUST00000045301.9 H1f3 ENSMUST00000045301.9 H1.3 linker histone, cluster member (from RefSeq NM_145713.4) ENSMUST00000045301.1 ENSMUST00000045301.2 ENSMUST00000045301.3 ENSMUST00000045301.4 ENSMUST00000045301.5 ENSMUST00000045301.6 ENSMUST00000045301.7 ENSMUST00000045301.8 H1f3 Hist1h1d NM_145713 Q149Z9 Q149Z9_MOUSE uc007pub.1 uc007pub.2 uc007pub.3 uc007pub.4 uc007pub.5 Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Sep 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Nucleus Belongs to the histone H1/H5 family. nucleosome nuclear chromatin DNA binding nucleus chromosome nuclear euchromatin nucleosome assembly chromatin DNA binding uc007pub.1 uc007pub.2 uc007pub.3 uc007pub.4 uc007pub.5 
ENSMUST00000045303.10 Spns2 ENSMUST00000045303.10 SPNS lysolipid transporter 2, sphingosine-1-phosphate, transcript variant 1 (from RefSeq NM_153060.3) B9A1T4 ENSMUST00000045303.1 ENSMUST00000045303.2 ENSMUST00000045303.3 ENSMUST00000045303.4 ENSMUST00000045303.5 ENSMUST00000045303.6 ENSMUST00000045303.7 ENSMUST00000045303.8 ENSMUST00000045303.9 NM_153060 Q5F242 Q8R119 Q91VM4 SPNS2_MOUSE Spns2 uc007jyz.1 uc007jyz.2 uc007jyz.3 uc007jyz.4 uc007jyz.5 Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate in the lymph, thereby playing a role in lymphocyte trafficking (PubMed:22664872, PubMed:23103166, PubMed:22406534, PubMed:23180825, PubMed:34260944). S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system (PubMed:22664872, PubMed:23103166, PubMed:22406534, PubMed:23180825, PubMed:34260944). Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking (PubMed:22664872, PubMed:22406534, PubMed:23180825, PubMed:34260944). Required for the egress of T-cells from lymph nodes during an immune response by mediating S1P secretion, which generates a gradient that enables activated T-cells to access lymph (PubMed:22406534, PubMed:34260944). Also required for the egress of immature B-cells from the bone marrow (PubMed:22406534). In contrast, it does not mediate S1P release from red blood cells (PubMed:23103166, PubMed:22406534). Involved in auditory function: S1P release in the inner ear is required for maintenance of the endocochlear potential in the cochlea (PubMed:25356849). In addition to export, also able to mediate S1P import (PubMed:33785361). Reaction=sphing-4-enine 1-phosphate(in) = sphing-4-enine 1- phosphate(out); Xref=Rhea:RHEA:38667, ChEBI:CHEBI:60119; Evidence=; Reaction=sphinganine 1-phosphate(in) = sphinganine 1-phosphate(out); Xref=Rhea:RHEA:38671, ChEBI:CHEBI:57939; Evidence=; Cell membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VM4-1; Sequence=Displayed; Name=2; IsoId=Q91VM4-2; Sequence=VSP_036390, VSP_036391; Expression is high in the lungs and liver, low in the lymph nodes, spleen and bone marrow, and very low but detectable in the thymus (PubMed:22664872). Not expressed in red blood cells (PubMed:23103166). Also expressed in the inner ear: expressed in the cochlea, both in the lateral wall and organ of Corti (PubMed:25356849). Deficient mice are viable, do not exhibit cardiac defects or embryonic lethality, and are generally normal and fertile (PubMed:22664872, PubMed:22406534). Deficient mice have decreased levels of sphingosine 1-phosphate (S1P) and dihydro-S1P in blood, accompanied by increases in very long chain ceramide species, and have defective lymphocyte trafficking (PubMed:22664872, PubMed:22406534, PubMed:23180825). S1P levels are increased in lymph from deficient mice as well as in specific tissues, including lymph nodes, and interstitial fluid (PubMed:23180825). Moreover, these mice have aberrant lymphatic sinus that appeared collapsed, with reduced numbers of lymphocytes (PubMed:23180825). Mice display marked accumulation of mature T-cells in thymus and decreased numbers of peripheral T-cells in blood and secondary lymphoid organs (PubMed:22406534, PubMed:34260944). Mature recirculating B-cells are reduced in frequency in the bone marrow as well as in blood and secondary lymphoid organs (PubMed:22406534). Mice do not show defects in S1P release from blood cells (PubMed:22406534). Knockout mice are protected against experimental autoimmune encephalomyelitis (PubMed:34260944). Mutants also show a profound hearing impairment, characterized by a progressive degeneration of sensory hair cells in the organ of Corti (PubMed:25356849, PubMed:30973865). Hearing loss is caused by a decline in the endocochlear potential (PubMed:25356849). Conditional deletion in the cochlea causes early onset progressive hearing loss (PubMed:25356849). In contrast, hearing impairment is not observed in mice with targeted deletion in red blood cells, platelets, lymphatic or vascular endothelial cells (PubMed:25356849). Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. Sequence=AAH11467.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; B cell homeostasis lymphocyte homeostasis regulation of humoral immune response sphingosine-1-phosphate signaling pathway integral component of plasma membrane sphingolipid metabolic process lipid transport membrane integral component of membrane T cell homeostasis sphingolipid transporter activity regulation of eye pigmentation lymph node development transmembrane transport bone development lymphocyte migration uc007jyz.1 uc007jyz.2 uc007jyz.3 uc007jyz.4 uc007jyz.5 
ENSMUST00000045312.6 Smc1a ENSMUST00000045312.6 structural maintenance of chromosomes 1A (from RefSeq NM_019710.2) A2AFQ5 ENSMUST00000045312.1 ENSMUST00000045312.2 ENSMUST00000045312.3 ENSMUST00000045312.4 ENSMUST00000045312.5 NM_019710 Q3V480 Q9CU62 Q9CUX9 Q9D959 Q9WTU1 SMC1A_MOUSE Sb1.8 Smc1 Smc1l1 Smcb uc009upx.1 uc009upx.2 uc009upx.3 uc009upx.4 Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (By similarity). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. Forms a heterodimer with SMC3 in cohesin complexes. Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their SMC hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. In germ cell cohesin complexes, SMC1A is mutually exclusive with SMC1B (PubMed:10375619). Interacts with STAG3 (PubMed:11483963). Found in a complex with CDCA5, SMC3 and RAD21, PDS5A/SCC-112 and PDS5B/APRIN. Found in a complex containing POLE and SMC3. Interacts with BRCA1, SYCP2, NDC80, RPGR and BRAT1. The cohesin complex interacts with the cohesin loading complex subunits NIPBL/Scc2 (via HEAT repeats) and MAU2/Scc4. NIPBL directly contacts all members of the complex, RAD21, SMC1A/B, SMC3 and STAG1 (By similarity). Q9CU62; Q61687: Atrx; NbExp=4; IntAct=EBI-2550016, EBI-2657527; Q9CU62; Q6A078: Cep290; NbExp=2; IntAct=EBI-2550016, EBI-1811999; Q9CU62; Q9Z2D6: Mecp2; NbExp=3; IntAct=EBI-2550016, EBI-1188816; Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function (By similarity). Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. Ubiquitous (at protein level). The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity). Phosphorylated upon ionizing radiation or DNA methylation. Phosphorylation of Ser-957 and Ser-966 activates it and is required for S-phase checkpoint activation (By similarity). Ubiquitinated by the DCX(DCAF15) complex, leading to its degradation. Belongs to the SMC family. SMC1 subfamily. nucleotide binding chromosome, centromeric region kinetochore chromatin binding protein binding ATP binding nucleus nucleoplasm chromosome cytosol DNA repair cellular response to DNA damage stimulus cell cycle sister chromatid cohesion mitotic sister chromatid cohesion cohesin complex response to radiation nuclear matrix stem cell population maintenance meiotic cohesin complex negative regulation of DNA endoreduplication mediator complex binding protein heterodimerization activity chromosome organization cell division meiotic cell cycle response to DNA damage checkpoint signaling mitotic spindle pole regulation of mitotic spindle assembly uc009upx.1 uc009upx.2 uc009upx.3 uc009upx.4 
ENSMUST00000045351.13 Atg2a ENSMUST00000045351.13 autophagy related 2A, transcript variant 5 (from RefSeq NR_176624.1) ATG2A_MOUSE Atg2a ENSMUST00000045351.1 ENSMUST00000045351.10 ENSMUST00000045351.11 ENSMUST00000045351.12 ENSMUST00000045351.2 ENSMUST00000045351.3 ENSMUST00000045351.4 ENSMUST00000045351.5 ENSMUST00000045351.6 ENSMUST00000045351.7 ENSMUST00000045351.8 ENSMUST00000045351.9 Kiaa0404 NR_176624 Q3U9I1 Q6P4T0 Q6PHN0 Q6ZQC4 Q8R213 uc008ghu.1 uc008ghu.2 uc008ghu.3 Lipid transfer protein involved in autophagosome assembly. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Also regulates lipid droplets morphology and distribution within the cell. (Microbial infection) Mediates the intracellular lifestyle of Cryptococcus neoformans by supporting infection. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2- diacyl-sn-glycero-3-phosphoethanolamine(out); Xref=Rhea:RHEA:38895, ChEBI:CHEBI:64612; Evidence=; Interacts with ATG9A (via C-terminus). Interacts with TMEM41B. Interacts with VMP1. Preautophagosomal structure membrane ; Peripheral membrane protein Lipid droplet Endoplasmic reticulum membrane ; Peripheral membrane protein Note=Localizes to endoplasmic reticulum-autophagosome contact sites. The chorein N-terminal domain mediates lipid transfer activity. Belongs to the ATG2 family. Sequence=BAC97942.1; Type=Erroneous initiation; Evidence=; Sequence=BAE30685.1; Type=Frameshift; Evidence=; autophagosome assembly pre-autophagosomal structure mitophagy molecular_function nucleus lipid particle cytosol autophagy membrane extrinsic component of membrane pre-autophagosomal structure membrane intracellular membrane-bounded organelle uc008ghu.1 uc008ghu.2 uc008ghu.3 
ENSMUST00000045356.9 Rpl37 ENSMUST00000045356.9 ribosomal protein L37 (from RefSeq NM_026069.4) ENSMUST00000045356.1 ENSMUST00000045356.2 ENSMUST00000045356.3 ENSMUST00000045356.4 ENSMUST00000045356.5 ENSMUST00000045356.6 ENSMUST00000045356.7 ENSMUST00000045356.8 NM_026069 Q6ZWV1 Q9D823 RL37_MOUSE uc007vcs.1 uc007vcs.2 uc007vcs.3 uc007vcs.4 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Cytoplasm Belongs to the eukaryotic ribosomal protein eL37 family. RNA binding structural constituent of ribosome ribosome translation growth factor binding rRNA binding cytosolic large ribosomal subunit synapse metal ion binding uc007vcs.1 uc007vcs.2 uc007vcs.3 uc007vcs.4 
ENSMUST00000045366.10 Dcun1d2 ENSMUST00000045366.10 defective in cullin neddylation 1 domain containing 2, transcript variant 7 (from RefSeq NM_001426635.1) DCNL2_MOUSE Dcun1d2 Dcun1l2 ENSMUST00000045366.1 ENSMUST00000045366.2 ENSMUST00000045366.3 ENSMUST00000045366.4 ENSMUST00000045366.5 ENSMUST00000045366.6 ENSMUST00000045366.7 ENSMUST00000045366.8 ENSMUST00000045366.9 NM_001426635 Q3U1U0 Q7TMX3 Q8BZJ7 SCCRO2 uc009kxg.1 uc009kxg.2 uc009kxg.3 Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and plays an essential role in the regulation of SCF (SKP1-CUL1-F-box protein)-type complexes activity. Interacts (via the DCUN1 domain) with the unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5; these interactions promote the cullin neddylation and the identity of the cullin dictates the affinity of the interaction. May also interact with regulators or subunits of cullin-RING ligases such as RBX1, RNF7, ELOB and DDB1; these interactions are bridged by cullins. Interacts with CAND1; this interaction is bridged by cullins such as CUL3 and strongly inhibits the neddylation of CUL3. These CAND-cullin-DCNL complexes can only be neddylated in the presence of a substrate adapter. Interacts (via DCUN1 domain) with the N-terminally acetylated form of UBE2M and UBE2F. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BZJ7-1; Sequence=Displayed; Name=2; IsoId=Q8BZJ7-2; Sequence=VSP_015318; Name=3; IsoId=Q8BZJ7-4; Sequence=VSP_027370; Highest levels of expression are in the skeletal muscle with relatively lower levels of expression in the heart and brain (PubMed:26792857). Very low levels of expression in the kidney, liver, spleen, lung, ovary and testis (PubMed:26792857). The DCUN1 domain, also known as PONY domain, mediates the interaction with different cullins. The DCUN1 domain mediates the interaction with the N-terminally acetylated NEDD8-conjugating E2s enzyme leading to the NEDD8 transfer from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes; the neddylation efficiency correlates with the DCUN1D5- cullin and DCUN1D5-E2 interaction affinities. [Isoform 2]: Splicing donor and acceptor site not canonical. Sequence=BC052676; Type=Frameshift; Evidence=; ubiquitin ligase complex ubiquitin conjugating enzyme binding ubiquitin-like protein binding protein neddylation positive regulation of ubiquitin-protein transferase activity cullin family protein binding uc009kxg.1 uc009kxg.2 uc009kxg.3 
ENSMUST00000045368.12 Abitram ENSMUST00000045368.12 actin binding transcription modulator (from RefSeq NM_001081420.1) ABITM_MOUSE ENSMUST00000045368.1 ENSMUST00000045368.10 ENSMUST00000045368.11 ENSMUST00000045368.2 ENSMUST00000045368.3 ENSMUST00000045368.4 ENSMUST00000045368.5 ENSMUST00000045368.6 ENSMUST00000045368.7 ENSMUST00000045368.8 ENSMUST00000045368.9 Fam206a NM_001081420 Q80ZQ9 Q8BWF9 Simiate uc008sxs.1 uc008sxs.2 uc008sxs.3 Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons. Interacts with F-actin (PubMed:24782708). Interacts with G- actin (PubMed:24782708). Nucleus speckle Cell projection, lamellipodium Nucleus Cell projection, growth cone Cell projection, dendrite Note=Localizes to somata and dendrites in cortical neurons. Colocalizes with G- and F-actin in growth cones and proximal dendrites (PubMed:24782708). Colocalizes in the nucleus with PTK2 (PubMed:24782708). Detected (at protein level) in liver, lung, heart, spleen, kidney, and ovaries. In brain expression is higher in the hippocampus, the nuclear layer of the cerebellum, the cortex and the caudoputamen. Belongs to the ABITRAM family. Sequence=BAC35079.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; actin binding actin monomer binding nucleus nuclear speck lamellipodium dendrite growth cone regulation of actin filament polymerization filopodium tip cell projection dendrite morphogenesis actin filament binding regulation of filopodium assembly uc008sxs.1 uc008sxs.2 uc008sxs.3 
ENSMUST00000045372.6 Bpgm ENSMUST00000045372.6 2,3-bisphosphoglycerate mutase, transcript variant 1 (from RefSeq NM_007563.5) ENSMUST00000045372.1 ENSMUST00000045372.2 ENSMUST00000045372.3 ENSMUST00000045372.4 ENSMUST00000045372.5 NM_007563 P15327 PMGE_MOUSE Q543Z6 uc009bhg.1 uc009bhg.2 uc009bhg.3 Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. Reaction=(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3- bisphosphoglycerate + H(+); Xref=Rhea:RHEA:17765, ChEBI:CHEBI:15378, ChEBI:CHEBI:57604, ChEBI:CHEBI:58248; EC=5.4.2.4; Evidence=; Reaction=(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; Xref=Rhea:RHEA:15901, ChEBI:CHEBI:58272, ChEBI:CHEBI:58289; EC=5.4.2.11; Evidence=; At alkaline pH BPGM favors the synthase reaction; however, at lower pH the phosphatase reaction is dominant. Inhibited by citrate. Homodimer. Expressed in red blood cells. Expressed in placenta (labyrinthine trophoblasts). Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. catalytic activity bisphosphoglycerate mutase activity phosphoglycerate mutase activity glycolytic process hydrolase activity isomerase activity intramolecular transferase activity, phosphotransferases erythrocyte development uc009bhg.1 uc009bhg.2 uc009bhg.3 
ENSMUST00000045374.8 Ramp3 ENSMUST00000045374.8 receptor (calcitonin) activity modifying protein 3 (from RefSeq NM_019511.3) ENSMUST00000045374.1 ENSMUST00000045374.2 ENSMUST00000045374.3 ENSMUST00000045374.4 ENSMUST00000045374.5 ENSMUST00000045374.6 ENSMUST00000045374.7 NM_019511 Q5SWP4 Q9WUP1 RAMP3_MOUSE uc007hzd.1 uc007hzd.2 uc007hzd.3 Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Interacts with GPER1 (By similarity). Heterodimer of CALCRL and RAMP3. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Expressed predominantly in the testis, embryonic and adult brain and in kidney. Belongs to the RAMP family. angiogenesis adrenomedullin receptor activity positive regulation of receptor recycling cell lysosome plasma membrane calcium ion transport intracellular protein transport G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway regulation of G-protein coupled receptor protein signaling pathway cell surface positive regulation of gene expression positive regulation of protein kinase A signaling positive regulation of cell death coreceptor activity protein transport membrane integral component of membrane receptor internalization cellular response to hormone stimulus positive regulation of peptidyl-serine phosphorylation cross-receptor inhibition within G-protein coupled receptor heterodimer receptor complex positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade cellular response to estradiol stimulus protein localization to plasma membrane G-protein coupled receptor signaling pathway involved in heart process amylin receptor activity amylin receptor signaling pathway positive regulation of protein localization to plasma membrane adrenomedullin receptor complex response to beta-amyloid positive regulation of calcium ion import across plasma membrane adrenomedullin receptor signaling pathway uc007hzd.1 uc007hzd.2 uc007hzd.3 
ENSMUST00000045376.11 Adk ENSMUST00000045376.11 adenosine kinase, transcript variant 1 (from RefSeq NM_134079.4) ADK_MOUSE ENSMUST00000045376.1 ENSMUST00000045376.10 ENSMUST00000045376.2 ENSMUST00000045376.3 ENSMUST00000045376.4 ENSMUST00000045376.5 ENSMUST00000045376.6 ENSMUST00000045376.7 ENSMUST00000045376.8 ENSMUST00000045376.9 NM_134079 P55264 Q6JAM3 Q91VJ3 uc007sld.1 uc007sld.2 uc007sld.3 Catalyzes the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. Reaction=adenosine + ATP = ADP + AMP + H(+); Xref=Rhea:RHEA:20824, ChEBI:CHEBI:15378, ChEBI:CHEBI:16335, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.1.20; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20825; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 3 Mg(2+) ions per subunit. ; Activity is inhibited by 5-iodotubercidin and 5'- amino-5'-deoxyadenosine. [Isoform 1]: Kinetic parameters: KM=20 nM for adenosine ; Vmax=16 nmol/min/ug enzyme with adenosine as substrat ; [Isoform 2]: Kinetic parameters: KM=20 nM for adenosine ; Vmax=16 nmol/min/ug enzyme with adenosine as substrat ; Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1. Monomer. [Isoform 1]: Nucleus [Isoform 2]: Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=AK-L , Long; IsoId=P55264-1; Sequence=Displayed; Name=2; Synonyms=AK-S , Short; IsoId=P55264-2; Sequence=VSP_014756; Widely expressed (PubMed:15317590). Highly expressed in liver, testis, kidney and spleen (at protein level). In brain, expression in most forebrain structures and the cerebellum is higher than in the midbrain and brainstem (at protein level) (PubMed:15317590). [Isoform 1]: Major isoform in testis and kidney. Not detected in most brain regions, except in the cerebellum, where it is expressed at a similar level to that of isoform 2 (at protein level). [Isoform 2]: Major isoform in spleen and in most brain regions, except in the cerebellum, where it is expressed at a similar level to that of isoform 1 (at protein level). Belongs to the carbohydrate kinase PfkB family. Sequence=AAA91649.1; Type=Erroneous initiation; Evidence=; nucleotide binding adenosine kinase activity ATP binding nucleus nucleoplasm cytoplasm cytosol purine ribonucleoside salvage dATP biosynthetic process positive regulation of cardiac muscle hypertrophy kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor positive regulation of T cell proliferation AMP salvage type B pancreatic cell proliferation adenosine metabolic process metal ion binding uc007sld.1 uc007sld.2 uc007sld.3 
ENSMUST00000045388.8 Lyplal1 ENSMUST00000045388.8 lysophospholipase-like 1 (from RefSeq NM_146106.2) E9QLB2 E9QLB2_MOUSE ENSMUST00000045388.1 ENSMUST00000045388.2 ENSMUST00000045388.3 ENSMUST00000045388.4 ENSMUST00000045388.5 ENSMUST00000045388.6 ENSMUST00000045388.7 Lyplal1 NM_146106 uc007dzm.1 uc007dzm.2 uc007dzm.3 uc007dzm.4 Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. cytosol hydrolase activity uc007dzm.1 uc007dzm.2 uc007dzm.3 uc007dzm.4 
ENSMUST00000045393.15 Adgrl1 ENSMUST00000045393.15 Membrane ; Multi- pass membrane protein (from UniProt H7BX15) AK147455 Adgrl1 ENSMUST00000045393.1 ENSMUST00000045393.10 ENSMUST00000045393.11 ENSMUST00000045393.12 ENSMUST00000045393.13 ENSMUST00000045393.14 ENSMUST00000045393.2 ENSMUST00000045393.3 ENSMUST00000045393.4 ENSMUST00000045393.5 ENSMUST00000045393.6 ENSMUST00000045393.7 ENSMUST00000045393.8 ENSMUST00000045393.9 H7BX15 H7BX15_MOUSE uc292bls.1 uc292bls.2 Membrane ; Multi- pass membrane protein transmembrane signaling receptor activity G-protein coupled receptor activity signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway membrane integral component of membrane carbohydrate binding uc292bls.1 uc292bls.2 
ENSMUST00000045396.9 Armh3 ENSMUST00000045396.9 armadillo-like helical domain containing 3 (from RefSeq NM_198296.2) ARMD3_MOUSE Armh3 ENSMUST00000045396.1 ENSMUST00000045396.2 ENSMUST00000045396.3 ENSMUST00000045396.4 ENSMUST00000045396.5 ENSMUST00000045396.6 ENSMUST00000045396.7 ENSMUST00000045396.8 NM_198296 Q3TWB1 Q6PD19 Q80V50 uc008hrv.1 uc008hrv.2 uc008hrv.3 Involved in GBF1 recruitment, Golgi maintenance and protein secretion. Interacts with PI4KB. Interacts with GBF1. Golgi apparatus membrane ; Single-pass type I membrane protein Cytoplasm Note=The majority of ARMD3 is cytosolic, with a portion colocalizing with GBF1 at juxtanuclear Golgi sites. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PD19-1; Sequence=Displayed; Name=2; IsoId=Q6PD19-2; Sequence=VSP_035671; Name=3; IsoId=Q6PD19-3; Sequence=VSP_035672, VSP_035673; Belongs to the ARMH3 family. Sequence=AAH46389.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008hrv.1 uc008hrv.2 uc008hrv.3 
ENSMUST00000045428.7 Fbxl21 ENSMUST00000045428.7 F-box and leucine-rich repeat protein 21, transcript variant 1 (from RefSeq NM_178674.5) B2RSN8 ENSMUST00000045428.1 ENSMUST00000045428.2 ENSMUST00000045428.3 ENSMUST00000045428.4 ENSMUST00000045428.5 ENSMUST00000045428.6 FXL21_MOUSE Fbl21 Fbxl3b NM_178674 Q8BFZ4 Q8BIJ8 Q8BIW5 uc007qsr.1 uc007qsr.2 Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities. Protein modification; protein ubiquitination. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL21) composed of CUL1, SKP1, RBX1 and FBXL21. Interacts with CRY1 and CRY2. Q8BFZ4; P97784: Cry1; NbExp=10; IntAct=EBI-6898235, EBI-1266607; Q8BFZ4; Q9R194: Cry2; NbExp=4; IntAct=EBI-6898235, EBI-1266619; Q8BFZ4; Q13616: CUL1; Xeno; NbExp=3; IntAct=EBI-6898235, EBI-359390; Q8BFZ4; P63208: SKP1; Xeno; NbExp=3; IntAct=EBI-6898235, EBI-307486; Cytoplasm, cytosol. Nucleus. Note=Mainly localizes in the cytosol. Present at low level in the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BFZ4-1; Sequence=Displayed; Name=2; IsoId=Q8BFZ4-2; Sequence=VSP_008415, VSP_008416; Expressed in the hypothalamus, especially in the suprachiasmatic nucleus (SCN). Expression is driven by the core-clock. There is a pronounced diurnal and circadian expression rhythms rising rapidly at the start of the day and declining at the onset of the night. Mice show normal periodicity of wheel-running rhythms with compromised organization of daily activities: mice do not display significant difference from their wild-type littermates in both the free-running period in constant darkness (DD) and activity onset in 12 hours of light/12 hours of darkness (LD). However, an alteration in the daily activities is observed: while wild-type mice show 2 peaks of activity during the active period, the late night activity is eliminated in Fbxl21-deficient mice. Mice lacking both Fbxl3 and Fbxl21 show an attenuated phenotype in behavioral rhythm compared to Fbxl3- deficient mice; however, they exhibit unstable behavioral rhythms, sometimes eliciting arrhythmicity. The mechanism by which the SCF(FBXL21) complex stabilizes CRY proteins (CRY1 and CRY2) is still unclear: according to a report, the SCF(FBXL21) complex does not catalyze 'Lys-48'-linked polyubiquitin chains, but catalyzes a different type of ubiquitin chains that do not lead to degradation (PubMed:23452856). According to a second report, FBXL21 has a higher affinity for CRY proteins compared to FBXL3, while the SCF(FBXL21) complex has weaker ubiquitin-ligase activity compared to the SCF(FBXL3) complex: as a consequence, the SCF(FBXL21) complex protects CRY proteins from SCF(FBXL3) activity and degradation in the nucleus, while it promotes slow degradation of CRY proteins in the cytosol (PubMed:23452855). Sequence=BAC37751.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; G2/M transition of mitotic cell cycle protein binding nucleus cytoplasm cytosol protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process entrainment of circadian clock by photoperiod rhythmic process regulation of cell cycle ubiquitin protein ligase activity uc007qsr.1 uc007qsr.2 
ENSMUST00000045441.8 Pygb ENSMUST00000045441.8 brain glycogen phosphorylase (from RefSeq NM_153781.1) ENSMUST00000045441.1 ENSMUST00000045441.2 ENSMUST00000045441.3 ENSMUST00000045441.4 ENSMUST00000045441.5 ENSMUST00000045441.6 ENSMUST00000045441.7 NM_153781 PYGB_MOUSE Q8CI94 Q8K283 uc008mul.1 uc008mul.2 uc008mul.3 Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Reaction=[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate; Xref=Rhea:RHEA:41732, Rhea:RHEA-COMP:9584, Rhea:RHEA-COMP:9586, ChEBI:CHEBI:15444, ChEBI:CHEBI:43474, ChEBI:CHEBI:58601; EC=2.4.1.1; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Activity of phosphorylase is controlled both by allosteric means (through the non-covalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates, whereas ATP, ADP, and glucose-6-phosphate allosterically inhibit, phosphorylase B (By similarity). Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A (By similarity). Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A. Belongs to the glycogen phosphorylase family. Sequence=AAH32209.1; Type=Erroneous initiation; Evidence=; catalytic activity phosphorylase activity cytoplasm carbohydrate metabolic process glycogen metabolic process glycogen catabolic process drug binding metabolic process glycogen phosphorylase activity transferase activity transferase activity, transferring glycosyl groups pyridoxal phosphate binding carbohydrate binding axon protein homodimerization activity uc008mul.1 uc008mul.2 uc008mul.3 
ENSMUST00000045450.7 Ints7 ENSMUST00000045450.7 integrator complex subunit 7, transcript variant 1 (from RefSeq NM_178632.6) A0A0R4J0E4 A0A0R4J0E4_MOUSE ENSMUST00000045450.1 ENSMUST00000045450.2 ENSMUST00000045450.3 ENSMUST00000045450.4 ENSMUST00000045450.5 ENSMUST00000045450.6 Ints7 NM_178632 uc007ecp.1 uc007ecp.2 uc007ecp.3 uc007ecp.4 Nucleus Belongs to the Integrator subunit 7 family. DNA damage checkpoint nucleus chromosome cytoplasm snRNA processing nuclear body integrator complex cellular response to ionizing radiation uc007ecp.1 uc007ecp.2 uc007ecp.3 uc007ecp.4 
ENSMUST00000045454.9 Slx9 ENSMUST00000045454.9 SLX9 ribosome biogenesis factor (from RefSeq NM_133998.3) ENSMUST00000045454.1 ENSMUST00000045454.2 ENSMUST00000045454.3 ENSMUST00000045454.4 ENSMUST00000045454.5 ENSMUST00000045454.6 ENSMUST00000045454.7 ENSMUST00000045454.8 Fam207a NM_133998 P58468 SLX9_MOUSE uc007fvt.1 uc007fvt.2 uc007fvt.3 uc007fvt.4 May be involved in ribosome biogenesis. Nucleus, nucleolus Belongs to the SLX9 family. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function cellular_component nucleolus biological_process 90S preribosome preribosome, small subunit precursor uc007fvt.1 uc007fvt.2 uc007fvt.3 uc007fvt.4 
ENSMUST00000045467.14 Hsd17b8 ENSMUST00000045467.14 hydroxysteroid 17-beta dehydrogenase 8 (from RefSeq NM_013543.2) DHB8_MOUSE ENSMUST00000045467.1 ENSMUST00000045467.10 ENSMUST00000045467.11 ENSMUST00000045467.12 ENSMUST00000045467.13 ENSMUST00000045467.2 ENSMUST00000045467.3 ENSMUST00000045467.4 ENSMUST00000045467.5 ENSMUST00000045467.6 ENSMUST00000045467.7 ENSMUST00000045467.8 ENSMUST00000045467.9 H2-Ke6 Hke6 NM_013543 P50171 Q5M9K0 Q60958 Q60959 Q9Z1W2 uc008cat.1 uc008cat.2 uc008cat.3 uc008cat.4 Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex, acts as scaffold protein, required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl- ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3- hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference, this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+)(H). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters (By similarity). NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. It efficiently catalyzes the oxidation of estradiol (E2), testosterone, and dihydrotestosterone. Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active estradiol (E2) (PubMed:9712896). Reaction=a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:32711, ChEBI:CHEBI:15378, ChEBI:CHEBI:57319, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.n12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32712; Evidence=; Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24613; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:24614; Evidence=; Reaction=NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:14929, ChEBI:CHEBI:15378, ChEBI:CHEBI:16422, ChEBI:CHEBI:17347, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.239; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14930; Evidence=; Reaction=17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha- androstan-3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:41992, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:16330, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41993; Evidence=; Kinetic parameters: KM=0.110 uM for estradiol ; KM=0.422 uM for testosterone ; KM=0.368 uM for estrone ; KM=0.360 uM for dihydrotestosterone ; Vmax=0.405 nmol/min/mg enzyme for estradiol as substrate ; Vmax=0.123 nmol/min/mg enzyme for testosterone as substrate ; Vmax=0.186 nmol/min/mg enzyme for estrone as substrate ; Vmax=0.081 nmol/min/mg enzyme for dihydrotestosterone as substrate ; Lipid metabolism; fatty acid biosynthesis. Steroid biosynthesis; estrogen biosynthesis. Lipid metabolism; mitochondrial fatty acid beta-oxidation. Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4. Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=Short; IsoId=P50171-1; Sequence=Displayed; Name=Long; IsoId=P50171-2; Sequence=VSP_006030; Kidney, liver, testis, ovary and spleen (PubMed:9712896, PubMed:15923359). Oviduct, uterus, mammary gland, vagina, prostate, clitoral gland and moderately heart, dorsal skin, brain and lung (PubMed:15923359). Belongs to the short-chain dehydrogenases/reductases (SDR) family. Sequence=AAC69902.1; Type=Erroneous gene model prediction; Evidence=; 3-hydroxyacyl-CoA dehydrogenase activity estradiol 17-beta-dehydrogenase activity mitochondrion mitochondrial envelope mitochondrial matrix plasma membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process steroid biosynthetic process estrogen biosynthetic process androgen metabolic process estrogen metabolic process membrane oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity testosterone dehydrogenase (NAD+) activity quinone binding protein heterotetramerization oxidation-reduction process NADH binding uc008cat.1 uc008cat.2 uc008cat.3 uc008cat.4 
ENSMUST00000045477.6 Stk32a ENSMUST00000045477.6 serine/threonine kinase 32A (from RefSeq NM_178749.3) ENSMUST00000045477.1 ENSMUST00000045477.2 ENSMUST00000045477.3 ENSMUST00000045477.4 ENSMUST00000045477.5 NM_178749 Q7TPQ4 Q8BGW6 ST32A_MOUSE Stk32a uc008eue.1 uc008eue.2 uc008eue.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cell membrane; Lipid-anchor Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8BGW6-1; Sequence=Displayed; Name=2 ; IsoId=Q8BGW6-2; Sequence=VSP_051996; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding plasma membrane protein phosphorylation membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction metal ion binding uc008eue.1 uc008eue.2 uc008eue.3 
ENSMUST00000045487.4 Rhou ENSMUST00000045487.4 ras homolog family member U (from RefSeq NM_133955.5) Arhu ENSMUST00000045487.1 ENSMUST00000045487.2 ENSMUST00000045487.3 G28k NM_133955 Q9EQT3 RHOU_MOUSE Rhou Wrch1 uc009nwm.1 uc009nwm.2 uc009nwm.3 Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with PAK3 (By similarity). Interacts with ARHGAP30 in a GTP-independent manner. In its GTP-loaded conformation, interacts with ARHGAP31. Interacts with PTK2B/PYK2 (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Golgi apparatus membrane ; Lipid-anchor Cell junction, focal adhesion Cell projection, podosome Note=Localizes to podosomes in SRC- transformed cells. Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation. Belongs to the small GTPase superfamily. Rho family. G1/S transition of mitotic cell cycle Golgi membrane nucleotide binding podosome GTPase activity GTP binding cytoplasm Golgi apparatus plasma membrane focal adhesion cell cortex endocytosis cytoskeleton organization actin filament organization establishment or maintenance of cell polarity small GTPase mediated signal transduction Rho protein signal transduction regulation of cell shape membrane Rac protein signal transduction protein kinase binding cell projection assembly actin cytoskeleton organization cell junction Cdc42 protein signal transduction regulation of actin cytoskeleton organization cell projection metal ion binding uc009nwm.1 uc009nwm.2 uc009nwm.3 
ENSMUST00000045513.13 Deup1 ENSMUST00000045513.13 deuterosome assembly protein 1, transcript variant 4 (from RefSeq NM_001373920.1) Ccdc67 DEUP1_MOUSE Deup1 E9QL16 ENSMUST00000045513.1 ENSMUST00000045513.10 ENSMUST00000045513.11 ENSMUST00000045513.12 ENSMUST00000045513.2 ENSMUST00000045513.3 ENSMUST00000045513.4 ENSMUST00000045513.5 ENSMUST00000045513.6 ENSMUST00000045513.7 ENSMUST00000045513.8 ENSMUST00000045513.9 NM_001373920 Q4VA46 Q7M6Y5 uc292eqw.1 uc292eqw.2 Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis. Interacts with CEP152; the interaction is mutually exclusive with CEP63. Q7M6Y5; A2AUM9: Cep152; NbExp=2; IntAct=EBI-16081624, EBI-2554268; Cytoplasm Note=Localizes to the deuterosome. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7M6Y5-1; Sequence=Displayed; Name=2; IsoId=Q7M6Y5-2; Sequence=VSP_041617; Highly enriched in multicilia-abundant tissues (trachea and oviduct). CEP63 and DEUP1 paralogs are both involved in centriole amplification: while CEP63 mediates mother-centriole-dependent centriole duplication, DEUP1 mediates de novo centriole amplification in multiciliated cells. Belongs to the CEP63 family. It is uncertain whether Met-1 or Met-22 is the initiator. Sequence=AAH96547.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=DAA01466.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding cytoplasm centriole centriole replication cell projection organization identical protein binding de novo centriole assembly involved in multi-ciliated epithelial cell differentiation deuterosome multi-ciliated epithelial cell differentiation uc292eqw.1 uc292eqw.2 
ENSMUST00000045521.9 Dtx4 ENSMUST00000045521.9 deltex 4, E3 ubiquitin ligase, transcript variant 1 (from RefSeq NM_172442.3) DTX4_MOUSE ENSMUST00000045521.1 ENSMUST00000045521.2 ENSMUST00000045521.3 ENSMUST00000045521.4 ENSMUST00000045521.5 ENSMUST00000045521.6 ENSMUST00000045521.7 ENSMUST00000045521.8 NM_172442 Q6IS30 Q6PDK8 Q8BID3 uc008guc.1 uc008guc.2 uc008guc.3 uc008guc.4 uc008guc.5 Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4 (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with NLRP4. Cytoplasm Expressed in brain, testis, embryonic fibroblasts and thymocytes. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. Belongs to the Deltex family. Sequence=BAC39704.1; Type=Frameshift; Evidence=; cellular_component cytoplasm Notch signaling pathway biological_process zinc ion binding protein ubiquitination transferase activity metal ion binding uc008guc.1 uc008guc.2 uc008guc.3 uc008guc.4 uc008guc.5 
ENSMUST00000045526.5 Mfsd4b2 ENSMUST00000045526.5 major facilitator superfamily domain containing 4B2 (from RefSeq NR_160807.1) ENSMUST00000045526.1 ENSMUST00000045526.2 ENSMUST00000045526.3 ENSMUST00000045526.4 NR_160807 uc007ewh.1 uc007ewh.2 uc007ewh.3 uc007ewh.1 uc007ewh.2 uc007ewh.3 
ENSMUST00000045529.3 Kiss1r ENSMUST00000045529.3 KISS1 receptor, transcript variant 1 (from RefSeq NM_053244.5) ENSMUST00000045529.1 ENSMUST00000045529.2 Gpr54 KISSR_MOUSE NM_053244 Q8K3P2 Q91V45 uc007gao.1 uc007gao.2 uc007gao.3 uc007gao.4 Receptor for metastin (kisspeptin-52 or kp-52), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. Cell membrane; Multi-pass membrane protein. Highest level in the heart and 15- and 17-day embryos. Low level in other tissues. Colocalized with gonadotropin- releasing hormone (GnRH) neurons in the hypothalamus. Belongs to the G-protein coupled receptor 1 family. activation of MAPKK activity G-protein coupled receptor activity protein binding plasma membrane integral component of plasma membrane cilium signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway neuropeptide receptor activity negative regulation of cell proliferation G-protein coupled peptide receptor activity cell surface membrane integral component of membrane calcium-mediated signaling neuropeptide binding intracellular membrane-bounded organelle positive regulation of hormone secretion arachidonic acid secretion positive regulation of synaptic transmission positive regulation of stress fiber assembly uc007gao.1 uc007gao.2 uc007gao.3 uc007gao.4 
ENSMUST00000045537.4 Chrm4 ENSMUST00000045537.4 cholinergic receptor, muscarinic 4, transcript variant 1 (from RefSeq NM_007699.3) Chrm4 ENSMUST00000045537.1 ENSMUST00000045537.2 ENSMUST00000045537.3 NM_007699 Q0VBU3 Q0VBU3_MOUSE uc033hoh.1 uc033hoh.2 The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled acetylcholine receptor signaling pathway membrane integral component of membrane G-protein coupled acetylcholine receptor activity cell junction regulation of locomotion synapse postsynaptic membrane uc033hoh.1 uc033hoh.2 
ENSMUST00000045540.4 Socs7 ENSMUST00000045540.4 Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). (from UniProt Q8VHQ2) AK147580 B1AQY1 Cish7 ENSMUST00000045540.1 ENSMUST00000045540.2 ENSMUST00000045540.3 Nap4 Q3UH08 Q8VHQ2 SOCS7_MOUSE uc007lea.1 uc007lea.2 Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Protein modification; protein ubiquitination. Interacts with phosphorylated IRS4 and PIK3R1. Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin and phosphorylated STAT3 and STAT5 (By similarity). Interacts with SEPT6 (By similarity). Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence (By similarity). Widely expressed with higher expression in brain and testis where it is expressed by spermatocytes and early spermatids. Also significantly expressed in spleen, skeletal muscle and kidney. Ubiquitously expressed at low level in 12.5 dpc and 15.5 dpc embryos. More significantly expressed in the nervous system at 12.5 dpc and the cortical plate at 15.5 dpc. Expressed in the brain postnatally in particular in the hippocampal formation and the medial habenular nuclei at P7. Low-level expression in other brain areas was present at P7 and was reduced to very low levels at P14 and P21. The hippocampal granule cell layer and the cerebellar granular layer maintained moderate expression levels at P7, P14, and P21. The SOCS box domain is required for IRS1 ubiquitination and subsequent proteasomal degradation. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. Mice are smaller and half of them develop fatal hydrocephalus between 3 to 15 weeks of age. They display subtle alterations in glucose homeostasis with an enhanced response to insulin which causes hypoglycemia. Pancreatic islets become progressively larger. protein binding nucleus cytoplasm cytosol plasma membrane phosphatidylinositol 3-kinase complex insulin receptor signaling pathway negative regulation of signal transduction membrane protein ubiquitination cerebral cortex radially oriented cell migration layer formation in cerebral cortex radial glia guided migration of Purkinje cell intracellular signal transduction regulation of growth regulation of phosphatidylinositol 3-kinase activity fat cell differentiation phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity uc007lea.1 uc007lea.2 
ENSMUST00000045542.13 Tesk2 ENSMUST00000045542.13 testis-specific kinase 2 (from RefSeq NM_146151.4) ENSMUST00000045542.1 ENSMUST00000045542.10 ENSMUST00000045542.11 ENSMUST00000045542.12 ENSMUST00000045542.2 ENSMUST00000045542.3 ENSMUST00000045542.4 ENSMUST00000045542.5 ENSMUST00000045542.6 ENSMUST00000045542.7 ENSMUST00000045542.8 ENSMUST00000045542.9 NM_146151 Q8VCT9 TESK2_MOUSE uc008uhj.1 uc008uhj.2 uc008uhj.3 uc008uhj.4 Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser- 3'. May play an important role in spermatogenesis (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Activated by autophosphorylation on Ser-219. Nucleus Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity ATP binding nucleus nucleoplasm cytoplasm protein phosphorylation spermatogenesis kinase activity phosphorylation nuclear body transferase activity peptidyl-tyrosine phosphorylation actin cytoskeleton organization metal ion binding focal adhesion assembly uc008uhj.1 uc008uhj.2 uc008uhj.3 uc008uhj.4 
ENSMUST00000045543.8 Ccdc106 ENSMUST00000045543.8 coiled-coil domain containing 106, transcript variant 2 (from RefSeq NM_146178.3) CC106_MOUSE ENSMUST00000045543.1 ENSMUST00000045543.2 ENSMUST00000045543.3 ENSMUST00000045543.4 ENSMUST00000045543.5 ENSMUST00000045543.6 ENSMUST00000045543.7 MNCb-2071 NM_146178 Q3ULM0 Q8K5E2 Q8VEI0 uc009ezs.1 uc009ezs.2 uc009ezs.3 uc009ezs.4 uc009ezs.5 Promotes the degradation of p53/TP53 protein and inhibits its transactivity. Interacts with p53/TP53. Nucleus Note=Colocalizes with p53/TP53. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3ULM0-1; Sequence=Displayed; Name=2; IsoId=Q3ULM0-2; Sequence=VSP_022717, VSP_022718; molecular_function nucleus cytosol biological_process uc009ezs.1 uc009ezs.2 uc009ezs.3 uc009ezs.4 uc009ezs.5 
ENSMUST00000045550.5 Xkr8 ENSMUST00000045550.5 X-linked Kx blood group related 8 (from RefSeq NM_201368.1) ENSMUST00000045550.1 ENSMUST00000045550.2 ENSMUST00000045550.3 ENSMUST00000045550.4 NM_201368 Q8C0T0 XKR8_MOUSE Xkr8 uc008vbr.1 uc008vbr.2 uc008vbr.3 [XK-related protein 8, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:25231987, PubMed:27503893, PubMed:29440417, PubMed:30718401). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:23845944, PubMed:29440417, PubMed:30718401, PubMed:31712393). Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina (PubMed:30559640, PubMed:29440417, PubMed:31712393). Has no effect on calcium-induced exposure of phosphatidylserine (By similarity). Promotes myoblast differentiation and survival (PubMed:28881496). [XK-related protein 8, processed form]: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence= Activated upon caspase cleavage to generate the XK-related protein 8, processed form (By similarity). Does not act prior the onset of apoptosis (By similarity). Interacts with BSG and NPTN; which act as chaperones to localize XKR8 at the cell membrane. [XK-related protein 8, processed form]: Homodimer. Cell membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region Widely expressed with higher expression in testis (PubMed:23845944). Expressed in the bone marrow and mononuclear leukocytes in the blood; highly expressed in thymocytes and lymphocytes (PubMed:29440417). Expressed in the mature retina (PubMed:30559640). Undergoes proteolytic processing by caspase-3 (CASP3), leading to its activation. Phosphorylation at Thr-375 activates the phospholipid scramblase activity. Conditional knockout mice show defects in phosphatidylserine exposure following apoptosis, leading to defects in engulfment of apoptotic cells (PubMed:23845944, PubMed:29440417). Mice on the MRL background develop a lupus-like autoimmune disease caused by impaired clearance of apoptotic lymphocytes and aged neutrophils (PubMed:29440417). Male mice are infertile due to reduced sperm counts in their epididymides: defects are caused by inefficient clearance of apoptotic germ cells by Sertoli cells in testes (PubMed:31712393). Belongs to the XK family. molecular_function plasma membrane apoptotic process membrane integral component of membrane engulfment of apoptotic cell phosphatidylserine exposure on apoptotic cell surface apoptotic process involved in development uc008vbr.1 uc008vbr.2 uc008vbr.3 
ENSMUST00000045555.11 Etl4 ENSMUST00000045555.11 enhancer trap locus 4, transcript variant a (from RefSeq NM_178059.5) A2AQ25 A2AUE9 A2AUF0 A2AUF1 ENSMUST00000045555.1 ENSMUST00000045555.10 ENSMUST00000045555.2 ENSMUST00000045555.3 ENSMUST00000045555.4 ENSMUST00000045555.5 ENSMUST00000045555.6 ENSMUST00000045555.7 ENSMUST00000045555.8 ENSMUST00000045555.9 Etl4 Kiaa1217 NM_178059 Q75UV8 Q75UV9 Q80VK2 Q8BHX8 Q8BHY1 Q8CHA8 Q8R0K6 SKT_MOUSE Skt uc008imn.1 uc008imn.2 uc008imn.3 Required for normal development of intervertebral disks. Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm Event=Alternative splicing; Named isoforms=9; Name=1; IsoId=A2AQ25-1; Sequence=Displayed; Name=2; IsoId=A2AQ25-2; Sequence=VSP_052416, VSP_052418; Name=3 ; Synonyms=Skt-a ; IsoId=A2AQ25-3; Sequence=VSP_052418, VSP_052421; Name=4 ; Synonyms=Skt-b ; IsoId=A2AQ25-4; Sequence=VSP_052418, VSP_052420, VSP_052421; Name=5; IsoId=A2AQ25-5; Sequence=VSP_052416, VSP_052418, VSP_052424, VSP_052425, VSP_052426; Name=6; IsoId=A2AQ25-6; Sequence=VSP_052416, VSP_052418, VSP_052421, VSP_052425, VSP_052426; Name=7 ; IsoId=A2AQ25-7; Sequence=VSP_052417; Name=8 ; IsoId=A2AQ25-8; Sequence=VSP_052418, VSP_052419; Name=9 ; IsoId=A2AQ25-9; Sequence=VSP_052416, VSP_052418, VSP_052420, VSP_052422, VSP_052423; Expressed predominantly in the notochord and mesonephros during embryogenesis as well as in other areas such as the epithalamus sulcus, lens vesicle, inner retinal layer, heart, hepatic primordial surface, infundibulum, surface ectoderm, hind gut and limb bud mesenchyme. In adults, expressed in a range of tissues including the nucleus pulposus, corpus callosum, kidney, cardiac muscle, Sertoli cells and hair follicles. Mice display a kinky-tail phenotype in about half of homozygotes with defects in the nucleus pulposus and annulus fibrosus of intertebral disks. Shortening and curving of caudal vertebrae 20-25 is apparent by the age of 2 weeks. Sequence=AAH26657.2; Type=Erroneous initiation; Evidence=; Sequence=BAC41473.2; Type=Erroneous initiation; Evidence=; molecular_function protein binding cytoplasm multicellular organism development embryonic skeletal system development uc008imn.1 uc008imn.2 uc008imn.3 
ENSMUST00000045557.10 Slc7a5 ENSMUST00000045557.10 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 (from RefSeq NM_011404.3) ENSMUST00000045557.1 ENSMUST00000045557.2 ENSMUST00000045557.3 ENSMUST00000045557.4 ENSMUST00000045557.5 ENSMUST00000045557.6 ENSMUST00000045557.7 ENSMUST00000045557.8 ENSMUST00000045557.9 LAT1_MOUSE Lat1 NM_011404 Q8R0X8 Q9JMI4 Q9Z127 uc009nsc.1 uc009nsc.2 uc009nsc.3 uc009nsc.4 The heterodimer with SLC3A2 functions as a sodium- independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, histidine, met hionine, tryptophan, valine, isoleucine and alanine (By similarity). The heterodimer with SLC3A2 mediates the uptake of L-DOPA and leucine (PubMed:9915839, PubMed:11011012). Functions as an amino acid exchanger (By similarity). May play a role in the transport of L-DOPA across the blood-brain barrier (PubMed:11011012). May act as the major transporter of tyrosine in fibroblasts (By similarity). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (By similarity). Reaction=L-phenylalanine(in) = L-phenylalanine(out); Xref=Rhea:RHEA:27950, ChEBI:CHEBI:58095; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:27952; Evidence=; Reaction=L-tryptophan(in) = L-tryptophan(out); Xref=Rhea:RHEA:70947, ChEBI:CHEBI:57912; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70949; Evidence=; Reaction=L-histidine(out) = L-histidine(in); Xref=Rhea:RHEA:72807, ChEBI:CHEBI:57595; Evidence=; Reaction=L-leucine(in) = L-leucine(out); Xref=Rhea:RHEA:73011, ChEBI:CHEBI:57427; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:73013; Evidence=; Reaction=L-isoleucine(in) = L-isoleucine(out); Xref=Rhea:RHEA:70943, ChEBI:CHEBI:58045; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70945; Evidence=; Reaction=L-valine(in) = L-valine(out); Xref=Rhea:RHEA:29703, ChEBI:CHEBI:57762; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29705; Evidence=; Reaction=L-tyrosine(in) = L-tyrosine(out); Xref=Rhea:RHEA:68572, ChEBI:CHEBI:58315; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68574; Evidence=; Reaction=L-methionine(in) = L-methionine(out); Xref=Rhea:RHEA:70939, ChEBI:CHEBI:57844; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70941; Evidence=; Reaction=L-alanine(in) = L-alanine(out); Xref=Rhea:RHEA:70719, ChEBI:CHEBI:57972; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70721; Evidence=; Reaction=3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in); Xref=Rhea:RHEA:71823, ChEBI:CHEBI:176514; Evidence=; Reaction=3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L- thyronine(in); Xref=Rhea:RHEA:71811, ChEBI:CHEBI:533015; Evidence=; Reaction=L-thyroxine(out) = L-thyroxine(in); Xref=Rhea:RHEA:71819, ChEBI:CHEBI:58448; Evidence=; Leucine uptake was inhibited by ileum, valine histidine and phenylalanine as well as by 2-amino-bicyclo-(2,2,1)- heptane-2-carboxylate (BCH) (a specific inhibitor of system L transport). Kinetic parameters: KM=25 uM for leucine ; Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (PubMed:9915839, PubMed:11011012). Interacts with LAPTM4B; this recruits the heterodimer formed by SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (By similarity). Apical cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Note=Located to the plasma membrane by SLC3A2/4F2hc (PubMed:9915839). Localized to the apical membrane of placental syncytiotrophoblastic cells. Recruited to lysosomes by LAPTM4B (By similarity). Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). Detected in brain, spleen, liver and testis (at protein level) (PubMed:9915839). Predominantly expressed in the microvessels in the brain parenchyma of the central nervous system. Also detected in the subfornical organ, the subcommissural organ, ventromedial nucleus of the hypothalamus, subgranular zone of the dentate gyrus in hippocampus, ependymal layer of the lateral ventricles, and the olfactory bulb. Very strong expression also seen in testis, ovary, and placenta with weaker expression in spleen, skin, brain, thymus, stomach, lung, heart, kidney, small intestine, uterus and skeletal muscle. Strong expression in the liver of 14 dpc embryo. In embryo of 18 dpc expressed strongly in brain, moderate expression in spleen and brain and weak expression in liver. Expression induced by concanavalin-A stimulation. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. lysosome lysosomal membrane cytosol plasma membrane amino acid transport L-amino acid transmembrane transporter activity L-leucine transmembrane transporter activity L-tryptophan transmembrane transporter activity branched-chain amino acid transport neutral amino acid transport L-amino acid transport membrane integral component of membrane apical plasma membrane transmembrane transporter activity intracellular membrane-bounded organelle transmembrane transport L-tryptophan transmembrane transport amino acid transport complex uc009nsc.1 uc009nsc.2 uc009nsc.3 uc009nsc.4 
ENSMUST00000045560.15 Slc19a3 ENSMUST00000045560.15 solute carrier family 19, member 3 (from RefSeq NM_030556.2) ENSMUST00000045560.1 ENSMUST00000045560.10 ENSMUST00000045560.11 ENSMUST00000045560.12 ENSMUST00000045560.13 ENSMUST00000045560.14 ENSMUST00000045560.2 ENSMUST00000045560.3 ENSMUST00000045560.4 ENSMUST00000045560.5 ENSMUST00000045560.6 ENSMUST00000045560.7 ENSMUST00000045560.8 ENSMUST00000045560.9 NM_030556 Q32MF5 Q99PL8 S19A3_MOUSE uc007bsi.1 uc007bsi.2 uc007bsi.3 High-affinity transporter for the intake of thiamine (PubMed:22194418, PubMed:35512554, PubMed:35724964). Unlike the human ortholog, lacks H(+)-dependent pyridoxine transport activity due to an absence of seven critical amino-acids required for pyridoxine transport (PubMed:35512554, PubMed:35724964). Reaction=H(+)(in) + thiamine(out) = H(+)(out) + thiamine(in); Xref=Rhea:RHEA:71271, ChEBI:CHEBI:15378, ChEBI:CHEBI:18385; Evidence= Membrane ; Multi-pass membrane protein High expression in kidney, brain, lung and small intestine (PubMed:11136550). Detected in pancreatic acinar cells (at protein level) (PubMed:22194418). Also expressed strongly in pancreatic islet cells (PubMed:22194418). Thiamine uptake by pancreatic acinar cells from knockout mice was found to be significantly lower than uptake by pancreatic acinar cells of the wild-type littermates. Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. plasma membrane thiamine transmembrane transporter activity folic acid transport thiamine transport membrane integral component of membrane vitamin transport transmembrane transport thiamine transmembrane transport vitamin transmembrane transporter activity folic acid transporter activity uc007bsi.1 uc007bsi.2 uc007bsi.3 
ENSMUST00000045562.6 Cox15 ENSMUST00000045562.6 cytochrome c oxidase assembly protein 15 (from RefSeq NM_144874.4) COX15_MOUSE ENSMUST00000045562.1 ENSMUST00000045562.2 ENSMUST00000045562.3 ENSMUST00000045562.4 ENSMUST00000045562.5 NM_144874 Q3URB2 Q8BJ03 Q8VDN0 Q921K5 uc008hot.1 uc008hot.2 uc008hot.3 May be involved in the biosynthesis of heme A. Mitochondrion membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BJ03-1; Sequence=Displayed; Name=2; IsoId=Q8BJ03-2; Sequence=VSP_011282; Belongs to the COX15/CtaA family. Sequence=AAH21498.1; Type=Erroneous initiation; Evidence=; nucleus mitochondrion mitochondrial inner membrane heme a biosynthetic process respiratory chain complex IV assembly membrane integral component of membrane oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor mitochondrial membrane oxidation-reduction process binding, bridging cytochrome complex hydrogen ion transmembrane transport uc008hot.1 uc008hot.2 uc008hot.3 
ENSMUST00000045593.12 Daglb ENSMUST00000045593.12 diacylglycerol lipase, beta (from RefSeq NM_144915.3) DGLB_MOUSE ENSMUST00000045593.1 ENSMUST00000045593.10 ENSMUST00000045593.11 ENSMUST00000045593.2 ENSMUST00000045593.3 ENSMUST00000045593.4 ENSMUST00000045593.5 ENSMUST00000045593.6 ENSMUST00000045593.7 ENSMUST00000045593.8 ENSMUST00000045593.9 NM_144915 Q8BU39 Q8BU97 Q8BV05 Q91WC9 uc009akj.1 uc009akj.2 uc009akj.3 Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:20159446, PubMed:20147530, PubMed:23103940). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (By similarity). Plays a key role in the regulation of 2- AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses (PubMed:23103940, PubMed:26779719). Functions also as a polyunsaturated fatty acids- specific triacylglycerol lipase in macrophages (PubMed:31991095). Plays an important role to support the metabolic and signaling demands of macrophages (PubMed:31991095, PubMed:23103940). Reaction=a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:33275, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17389, ChEBI:CHEBI:17815, ChEBI:CHEBI:28868; EC=3.1.1.116; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33276; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate; Xref=Rhea:RHEA:38507, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:52392, ChEBI:CHEBI:75728; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)- octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38511, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52333, ChEBI:CHEBI:73990; Evidence=; Reaction=1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn- glycerol + H2O = (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38515, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52392, ChEBI:CHEBI:75449; Evidence=; Reaction=1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = (9Z)- octadecenoate + 2-octadecanoylglycerol + H(+); Xref=Rhea:RHEA:38519, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75448, ChEBI:CHEBI:75456; Evidence=; Reaction=1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+); Xref=Rhea:RHEA:38523, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75450, ChEBI:CHEBI:75457; Evidence=; Reaction=1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn- glycerol + H2O = (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)- eicosatetraenylglycerol + H(+); Xref=Rhea:RHEA:38527, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75913, ChEBI:CHEBI:75914; Evidence=; Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12045; Evidence=; Reaction=1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-glycerol + H(+); Xref=Rhea:RHEA:63432, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:147308, ChEBI:CHEBI:147309; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63433; Evidence=; Reaction=1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di- (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+); Xref=Rhea:RHEA:63436, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:77016, ChEBI:CHEBI:147310, ChEBI:CHEBI:147311; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Inhibited by the 1,2,3-triazole urea covalent inhibitors KT109 and KT172 (PubMed:23103940, PubMed:31991095). Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not by PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation (By similarity). Cell membrane ; Multi-pass membrane protein Expressed in liver and immune cells such as macrophages and microglias (PubMed:23103940, PubMed:31991095, PubMed:26779719, PubMed:20147530). In embryonic brains present in axonal tracts, while in adults localizes to dendritic fields, correlating with the developmental change in requirement for 2-AG synthesis from the pre- to the postsynaptic compartment (at protein level) (PubMed:14610053). Deficient mice are viable, fertile and display normal physiological behaviors (PubMed:20159446, PubMed:20147530). Levels of 2-AG are reduced by up to 90% in liver (PubMed:20147530). In contrast, brain 2-AG and arachidonic acid (AA) content are unaltered in deficient mice (PubMed:20159446, PubMed:23103940, PubMed:26779719). However one report describes a decreased by up to 50% of 2-AG in the brain (PubMed:20147530). Disruption of Daglb results in depletion of 2- AG, AA, and prostaglandins (PGE2 and PGD2) in microglia and macrophages, and also attenuated pro-inflammatorycytokine (TNF-alpha) signaling in response to lipopolysaccharide stimulation (PubMed:26779719, PubMed:23103940). In contrast, lipid profiles of neurons are not impacted (PubMed:26779719). Endocannabinoid-mediated retrograde synaptic suppression is intact in deficient mice (PubMed:20159446). Belongs to the AB hydrolase superfamily. Lipase family. Sequence=BAC39734.1; Type=Frameshift; Evidence=; nucleus plasma membrane lipid metabolic process G-protein coupled glutamate receptor signaling pathway neuroblast proliferation membrane integral component of membrane lipid catabolic process hydrolase activity arachidonic acid metabolic process neurogenesis neurotransmitter biosynthetic process postsynaptic membrane diacylglycerol catabolic process metal ion binding endocannabinoid signaling pathway retrograde trans-synaptic signaling by endocannabinoid uc009akj.1 uc009akj.2 uc009akj.3 
ENSMUST00000045602.9 Ndufb10 ENSMUST00000045602.9 NADH:ubiquinone oxidoreductase subunit B10 (from RefSeq NM_026684.3) ENSMUST00000045602.1 ENSMUST00000045602.2 ENSMUST00000045602.3 ENSMUST00000045602.4 ENSMUST00000045602.5 ENSMUST00000045602.6 ENSMUST00000045602.7 ENSMUST00000045602.8 NDUBA_MOUSE NM_026684 Q3UAE3 Q9DCS9 uc008ayd.1 uc008ayd.2 uc008ayd.3 Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Interacts with CHCHD4. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the complex I NDUFB10 subunit family. molecular_function mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc008ayd.1 uc008ayd.2 uc008ayd.3 
ENSMUST00000045604.4 Mrpl41 ENSMUST00000045604.4 mitochondrial ribosomal protein L41 (from RefSeq NM_001031808.2) ENSMUST00000045604.1 ENSMUST00000045604.2 ENSMUST00000045604.3 NM_001031808 Q8BJ44 Q9CQN7 RM41_MOUSE uc033hls.1 uc033hls.2 uc033hls.3 Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with BCL2. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mL41 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation apoptotic process cell cycle ribonucleoprotein complex uc033hls.1 uc033hls.2 uc033hls.3 
ENSMUST00000045607.12 Melk ENSMUST00000045607.12 maternal embryonic leucine zipper kinase, transcript variant 1 (from RefSeq NM_010790.3) ENSMUST00000045607.1 ENSMUST00000045607.10 ENSMUST00000045607.11 ENSMUST00000045607.2 ENSMUST00000045607.3 ENSMUST00000045607.4 ENSMUST00000045607.5 ENSMUST00000045607.6 ENSMUST00000045607.7 ENSMUST00000045607.8 ENSMUST00000045607.9 Kiaa0175 MELK_MOUSE NM_010790 Pk38 Q3TPU1 Q61804 Q61846 Q6ZQH6 uc008srv.1 uc008srv.2 uc008srv.3 Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Activated by autophosphorylation of the T-loop at Thr-167 and Ser-171: in contrast to other members of the SNF1 subfamily, phosphorylation at Thr-167 is not mediated by STK11/LKB1 but via autophosphorylation instead. Inhibited by calcium-binding. Kinase activity is also regulated by reducing agents: dithiothreitol (DTT) or reduced glutathione are required for kinase activity in vitro; such dependence is however not due to the presence of disulfide bonds (By similarity). Monomer. Interacts with ZNF622 and PPP1R8 (By similarity). Cell membrane ; Peripheral membrane protein Expressed in testis, ovary, thymus, spleen and T- cell. Expressed by neural progenitors: highly enriched in cultures containing multipotent progenitors. Expressed in the 2-cell-stage embryo, followed by a strong expression at 8-cell-stage. The KA1 domain mediates binding to phospholipids and targeting to membranes. Autophosphorylated: autophosphorylation of the T-loop at Thr-167 and Ser-171 is required for activation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity non-membrane spanning protein tyrosine kinase activity calcium ion binding protein binding ATP binding nucleus cytoplasm plasma membrane cell cortex protein phosphorylation apoptotic process cell cycle cell proliferation lipid binding intrinsic apoptotic signaling pathway in response to oxidative stress membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation hemopoiesis intracellular signal transduction positive regulation of apoptotic process protein autophosphorylation neural precursor cell proliferation uc008srv.1 uc008srv.2 uc008srv.3 
ENSMUST00000045617.15 Hpse ENSMUST00000045617.15 heparanase (from RefSeq NM_152803.5) B2RS99 ENSMUST00000045617.1 ENSMUST00000045617.10 ENSMUST00000045617.11 ENSMUST00000045617.12 ENSMUST00000045617.13 ENSMUST00000045617.14 ENSMUST00000045617.2 ENSMUST00000045617.3 ENSMUST00000045617.4 ENSMUST00000045617.5 ENSMUST00000045617.6 ENSMUST00000045617.7 ENSMUST00000045617.8 ENSMUST00000045617.9 HPSE_MOUSE Hpa NM_152803 Q6YGZ1 Q8K3K3 uc008yhw.1 uc008yhw.2 uc008yhw.3 This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteoglycans associated with the cell surface and extracellular matrix. Mice lacking the encoded protein do not show any prominent pathological alterations under normal conditions but fail to develop albuminuria and renal damage in response to drug-induced diabetes. [provided by RefSeq, Aug 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK154628.1, SRR1660817.32164.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as a procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis. Reaction=endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan.; EC=3.2.1.166; Evidence=; Inhibited by EDTA and activated by calcium and magnesium (By similarity). Inhibited by laminarin sulfate and, to a lower extent, by heparin and sulfamin. pH dependence: Optimum pH is 5. ; Heterodimer; heterodimer formation between the 8 kDa and the 50 kDa subunits is required for enzyme activity. Interacts with TF; the interaction, inhibited by heparin, enhances the generation of activated factor X and activates coagulation. Interacts with HRG; the interaction is enhanced at acidic pH, partially inhibits binding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts with SDC1; the interaction enhances the shedding of SDC1 (By similarity). Interacts with HPSE2 (By similarity). Lysosome membrane ; Peripheral membrane protein Secreted Nucleus Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). Associates with lipid rafts. Expressed in skin, mainly in the stratum granulosum and the first layer of the stratum corneum in the upper part of the epidermis. Also detected in hair follicles and in sebaceous glands. In 18.5 day embryos, expressed in the peri- chondrium, periosteum and at the chondro-osseus junction of developing bone. Proteolytically processed. The cleavage of the 65 kDa form leads to the generation of a linker peptide, and the 8 kDa and 50 kDa products. The active form, the 8/50 kDa heterodimer, is resistant to degradation. Complete removal of the linker peptide appears to be a prerequisite to the complete activation of the enzyme (By similarity). N-glycosylated. Glycosylation of the 50 kDa subunit appears to be essential for its solubility. Belongs to the glycosyl hydrolase 79 family. extracellular region nucleus nucleoplasm lysosome lysosomal membrane cell adhesion cell-matrix adhesion positive regulation of vascular endothelial growth factor production membrane hydrolase activity hydrolase activity, acting on glycosyl bonds positive regulation of blood coagulation heparan sulfate proteoglycan catabolic process heparanase activity extracellular matrix positive regulation of osteoblast proliferation wound healing intracellular membrane-bounded organelle membrane raft syndecan binding protein dimerization activity regulation of hair follicle development positive regulation of hair follicle development positive regulation of protein kinase B signaling angiogenesis involved in wound healing vascular wound healing uc008yhw.1 uc008yhw.2 uc008yhw.3 
ENSMUST00000045628.15 R3hdm4 ENSMUST00000045628.15 R3H domain containing 4, transcript variant 2 (from RefSeq NM_177994.5) ENSMUST00000045628.1 ENSMUST00000045628.10 ENSMUST00000045628.11 ENSMUST00000045628.12 ENSMUST00000045628.13 ENSMUST00000045628.14 ENSMUST00000045628.2 ENSMUST00000045628.3 ENSMUST00000045628.4 ENSMUST00000045628.5 ENSMUST00000045628.6 ENSMUST00000045628.7 ENSMUST00000045628.8 ENSMUST00000045628.9 NM_177994 Q4VBF2 Q8BJN1 Q8CGD7 Q8JZZ8 R3HD4_MOUSE uc007gan.1 uc007gan.2 uc007gan.3 Nucleus Sequence=AAH34653.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH40686.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function nucleic acid binding cellular_component nucleus biological_process uc007gan.1 uc007gan.2 uc007gan.3 
ENSMUST00000045633.6 Mybbp1a ENSMUST00000045633.6 MYB binding protein (P160) 1a (from RefSeq NM_016776.3) ENSMUST00000045633.1 ENSMUST00000045633.2 ENSMUST00000045633.3 ENSMUST00000045633.4 ENSMUST00000045633.5 MBB1A_MOUSE NM_016776 O35851 P160 Q7TPV4 Q80Y66 Q8R4X2 Q99KP0 uc007jyy.1 uc007jyy.2 uc007jyy.3 May activate or repress transcription via interactions with sequence specific DNA-binding proteins (PubMed:9447996, PubMed:11956195, PubMed:14744933). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (PubMed:14744933). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (PubMed:19129230). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (PubMed:19129230). Has a role in rRNA biogenesis together with PWP1 (By similarity). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (By similarity). Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2. Interacts with CLOCK and CRY1. Q7TPV4; P12813: Nr4a1; NbExp=3; IntAct=EBI-1373622, EBI-10896863; Nucleus Nucleus, nucleolus Cytoplasm Note=Predominantly nucleolar. Also shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1. Ubiquitously expressed. Citrullinated by PADI4. Belongs to the MYBBP1A family. DNA binding transcription corepressor activity protein binding nucleus nucleolus cytoplasm regulation of transcription, DNA-templated transcription factor binding zinc ion binding respiratory electron transport chain circadian regulation of gene expression cellular response to glucose starvation ribosome biogenesis NLS-dependent protein nuclear import complex intracellular membrane-bounded organelle sequence-specific DNA binding negative regulation of transcription, DNA-templated rhythmic process E-box binding positive regulation of cell cycle arrest intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of anoikis uc007jyy.1 uc007jyy.2 uc007jyy.3 
ENSMUST00000045644.9 Actr5 ENSMUST00000045644.9 ARP5 actin-related protein 5 (from RefSeq NM_175419.4) A0A0A0MQ89 A0A0A0MQ89_MOUSE Actr5 ENSMUST00000045644.1 ENSMUST00000045644.2 ENSMUST00000045644.3 ENSMUST00000045644.4 ENSMUST00000045644.5 ENSMUST00000045644.6 ENSMUST00000045644.7 ENSMUST00000045644.8 NM_175419 uc008nqm.1 uc008nqm.2 uc008nqm.3 Nucleus Belongs to the actin family. ARP5 subfamily. nucleus cytoplasm double-strand break repair Ino80 complex UV-damage excision repair uc008nqm.1 uc008nqm.2 uc008nqm.3 
ENSMUST00000045664.7 Atad2b ENSMUST00000045664.7 ATPase family, AAA domain containing 2B (from RefSeq NM_001362349.1) Atad2b E9Q166 E9Q166_MOUSE ENSMUST00000045664.1 ENSMUST00000045664.2 ENSMUST00000045664.3 ENSMUST00000045664.4 ENSMUST00000045664.5 ENSMUST00000045664.6 NM_001362349 uc033gcm.1 uc033gcm.2 uc033gcm.3 Belongs to the AAA ATPase family. chromatin binding ATP binding nucleus nucleoplasm ATPase activity negative regulation of chromatin silencing histone binding positive regulation of transcription from RNA polymerase II promoter lysine-acetylated histone binding uc033gcm.1 uc033gcm.2 uc033gcm.3 
ENSMUST00000045665.13 Ppp1r12b ENSMUST00000045665.13 protein phosphatase 1, regulatory subunit 12B, transcript variant 4 (from RefSeq NM_001368829.1) ENSMUST00000045665.1 ENSMUST00000045665.10 ENSMUST00000045665.11 ENSMUST00000045665.12 ENSMUST00000045665.2 ENSMUST00000045665.3 ENSMUST00000045665.4 ENSMUST00000045665.5 ENSMUST00000045665.6 ENSMUST00000045665.7 ENSMUST00000045665.8 ENSMUST00000045665.9 MYPT2_MOUSE Mypt2 NM_001368829 Q8BG95 Q8BXY7 Q9D8S6 uc287lxm.1 uc287lxm.2 Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus (By similarity). PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12B mediates binding to myosin. Isoform 3 and isoform 4 bind PPP1R12A, but not isoform 1 of PPP1R12B itself. Binds IL16 (By similarity). Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, stress fiber Note=Along actomyosin filaments. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BG95-1; Sequence=Displayed; Name=2; IsoId=Q8BG95-2; Sequence=VSP_009260, VSP_009261; enzyme inhibitor activity cytoplasm cytoskeleton signal transduction biological_process phosphatase regulator activity protein kinase binding Z disc A band negative regulation of catalytic activity regulation of catalytic activity uc287lxm.1 uc287lxm.2 
ENSMUST00000045674.4 Plpp6 ENSMUST00000045674.4 phospholipid phosphatase 6 (from RefSeq NM_028922.3) ENSMUST00000045674.1 ENSMUST00000045674.2 ENSMUST00000045674.3 NM_028922 PLPP6_MOUSE Plpp6 Q9D4F2 uc008hcr.1 uc008hcr.2 uc008hcr.3 uc008hcr.4 Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates. Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation. May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway. May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins. Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols. May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine- 1-phosphate. Reaction=H2O + presqualene diphosphate = H(+) + phosphate + presqualene monophosphate; Xref=Rhea:RHEA:67968, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57310, ChEBI:CHEBI:176803; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67969; Evidence=; Reaction=H2O + presqualene monophosphate = phosphate + presqualene alcohol; Xref=Rhea:RHEA:68024, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:176803, ChEBI:CHEBI:176962; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68025; Evidence=; Reaction=(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:48128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:88226, ChEBI:CHEBI:175763; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48129; Evidence=; Reaction=(2E,6E)-farnesyl phosphate + H2O = (2E,6E)-farnesol + phosphate; Xref=Rhea:RHEA:48132, ChEBI:CHEBI:15377, ChEBI:CHEBI:16619, ChEBI:CHEBI:43474, ChEBI:CHEBI:88226; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48133; Evidence=; Reaction=(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)- geranylgeranyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:68008, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58756, ChEBI:CHEBI:144936; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68009; Evidence=; Reaction=(2E,6E,10E)-geranylgeranyl phosphate + H2O = (2E,6E,10E)- geranylgeraniol + phosphate; Xref=Rhea:RHEA:68016, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46762, ChEBI:CHEBI:144936; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68017; Evidence=; Reaction=(2E)-geranyl diphosphate + H2O = (2E)-geranyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:47944, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58057, ChEBI:CHEBI:88107; EC=3.6.1.68; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47945; Evidence=; Reaction=(2E)-geranyl phosphate + H2O = (2E)-geraniol + phosphate; Xref=Rhea:RHEA:68020, ChEBI:CHEBI:15377, ChEBI:CHEBI:17447, ChEBI:CHEBI:43474, ChEBI:CHEBI:88107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68021; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2- dihexadecanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:43236, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:72859, ChEBI:CHEBI:82929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43237; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Nucleus envelope Nucleus inner membrane Phosphorylation by PKC activates the phosphatase activity towards presqualene diphosphate. Belongs to the PA-phosphatase related phosphoesterase family. cellular_component membrane integral component of membrane hydrolase activity lipid phosphatase activity phospholipid dephosphorylation uc008hcr.1 uc008hcr.2 uc008hcr.3 uc008hcr.4 
ENSMUST00000045682.7 Gramd1b ENSMUST00000045682.7 GRAM domain containing 1B, transcript variant 1 (from RefSeq NM_172768.2) ASTRB_MOUSE ENSMUST00000045682.1 ENSMUST00000045682.2 ENSMUST00000045682.3 ENSMUST00000045682.4 ENSMUST00000045682.5 ENSMUST00000045682.6 Kiaa1201 NM_172768 Q6NS56 Q80TI0 Q8BZZ1 Q9CTQ2 uc009ozq.1 uc009ozq.2 uc009ozq.3 Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461). Endoplasmic reticulum membrane ; Single-pass membrane protein Cell membrane ; Single-pass membrane protein Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80TI0-1; Sequence=Displayed; Name=2; IsoId=Q80TI0-2; Sequence=VSP_025473; Name=3; IsoId=Q80TI0-3; Sequence=VSP_025474; Name=4; IsoId=Q80TI0-4; Sequence=VSP_025475, VSP_025476; Highly expressed in the adrenal gland (at protein level) and brain. Also found in the kidney, testis and macrophages. By NR1H2/LXRB and NR1H3/LXRA. GRAM domain binds phosphatidylserine in the PM and mediates protein recruitment to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM. VASt (VAD1 Analog of StAR-related lipid transfer) domain, also known as ASTER (Greek for star) domain is a sterol-binding domain. Mice exhibit deficiency in adrenal cholesterol ester storage and steroidogenesis. Sequence=BAC65747.1; Type=Erroneous initiation; Evidence=; phosphatidylserine binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane lipid transport lipid binding cholesterol binding sterol transport membrane integral component of membrane cholesterol homeostasis phosphatidic acid binding cellular response to cholesterol uc009ozq.1 uc009ozq.2 uc009ozq.3 
ENSMUST00000045692.9 Fbxl16 ENSMUST00000045692.9 F-box and leucine-rich repeat protein 16, transcript variant 2 (from RefSeq NM_001379393.1) B2RPY3 B2RPY3_MOUSE ENSMUST00000045692.1 ENSMUST00000045692.2 ENSMUST00000045692.3 ENSMUST00000045692.4 ENSMUST00000045692.5 ENSMUST00000045692.6 ENSMUST00000045692.7 ENSMUST00000045692.8 Fbxl16 NM_001379393 uc012anl.1 uc012anl.2 uc012anl.3 uc012anl.4 cytoplasm uc012anl.1 uc012anl.2 uc012anl.3 uc012anl.4 
ENSMUST00000045693.8 Smyd5 ENSMUST00000045693.8 SET and MYND domain containing 5 (from RefSeq NM_144918.2) ENSMUST00000045693.1 ENSMUST00000045693.2 ENSMUST00000045693.3 ENSMUST00000045693.4 ENSMUST00000045693.5 ENSMUST00000045693.6 ENSMUST00000045693.7 NM_144918 Q3TRB2 Q3TYX3 Q91YL6 Rai15 SMYD5_MOUSE uc009cpq.1 uc009cpq.2 uc009cpq.3 Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression (PubMed:22921934, PubMed:28250819). In association with the NCoR corepressor complex, is involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the formation of H4K20me3 at the gene promoters (PubMed:22921934). Plays an important role in embryonic stem (ES) cell self-renewal and differentiation (PubMed:28951459). Promotes ES cell maintenance by silencing differentiation genes through deposition of H4K20me3 marks (PubMed:28951459). Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by depositing H4K20me3 marks (PubMed:28250819). Reaction=L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:64456, Rhea:RHEA-COMP:15554, Rhea:RHEA- COMP:15998, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.372; Evidence=; Interacts with the N-CoR complex (PubMed:22921934). Interacts with EHMT2 and CBX5 (PubMed:28250819). Up-regulated by retinoic acid treatment in embryonic carcinoma cells. Present at low levels in untreated cells. Belongs to the class V-like SAM-binding methyltransferase superfamily. Sequence=AAH16525.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process methyltransferase activity transferase activity methylation metal ion binding uc009cpq.1 uc009cpq.2 uc009cpq.3 
ENSMUST00000045697.12 Mrpl55 ENSMUST00000045697.12 mitochondrial ribosomal protein L55, transcript variant 4 (from RefSeq NM_026035.4) ENSMUST00000045697.1 ENSMUST00000045697.10 ENSMUST00000045697.11 ENSMUST00000045697.2 ENSMUST00000045697.3 ENSMUST00000045697.4 ENSMUST00000045697.5 ENSMUST00000045697.6 ENSMUST00000045697.7 ENSMUST00000045697.8 ENSMUST00000045697.9 NM_026035 Q8R030 Q9CZ83 RM55_MOUSE uc007jdi.1 uc007jdi.2 uc007jdi.3 uc007jdi.4 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZ83-1; Sequence=Displayed; Name=2; IsoId=Q9CZ83-2; Sequence=VSP_022478; Belongs to the mitochondrion-specific ribosomal protein mL55 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation uc007jdi.1 uc007jdi.2 uc007jdi.3 uc007jdi.4 
ENSMUST00000045702.6 Slc2a6 ENSMUST00000045702.6 solute carrier family 2 (facilitated glucose transporter), member 6, transcript variant 1 (from RefSeq NM_172659.2) A2AR26 ENSMUST00000045702.1 ENSMUST00000045702.2 ENSMUST00000045702.3 ENSMUST00000045702.4 ENSMUST00000045702.5 GTR6_MOUSE Glut6 NM_172659 Q3TLU5 Q3UDF0 Q8BTN2 Slc2a6 uc008iwv.1 uc008iwv.2 uc008iwv.3 Probable sugar transporter that acts as a regulator of glycolysis in macrophages (PubMed:30431159). Does not transport glucose (By similarity). Lysosome membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UDF0-1; Sequence=Displayed; Name=2; IsoId=Q3UDF0-2; Sequence=VSP_060214; Mainly expressed in brain and spleen (PubMed:29664675). Also expressed in lung, heart, muscle, liver, kidney, fat, whole blood, testes, ovaries and uterus (PubMed:29664675). Mild metabolic effects (PubMed:29664675, PubMed:30431159). Mice grow normally and glucose metabolism in male or female mice is normal (PubMed:29664675). Minimal metabolic effects are observed: female mice display a minor decrease in fat accumulation when fed Western diet and have a lower respiratory exchange ratio when fed chow diet (PubMed:29664675). Mice also exhibit a subtle phenotype in response to lipopolysaccharide administration, characterized by slight changes in the metabolome associated with glycolysis (PubMed:30431159). Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. sugar:proton symporter activity lysosome lysosomal membrane integral component of plasma membrane regulation of glycolytic process carbohydrate transport membrane integral component of membrane transmembrane transporter activity carbohydrate transmembrane transport transmembrane transport hydrogen ion transmembrane transport glucose transmembrane transport glucose transmembrane transporter activity uc008iwv.1 uc008iwv.2 uc008iwv.3 
ENSMUST00000045705.14 Ambra1 ENSMUST00000045705.14 autophagy/beclin 1 regulator 1, transcript variant 1 (from RefSeq NM_172669.3) A2AH21 A2AH22 A2AH24 AMRA1_MOUSE Ambra1 ENSMUST00000045705.1 ENSMUST00000045705.10 ENSMUST00000045705.11 ENSMUST00000045705.12 ENSMUST00000045705.13 ENSMUST00000045705.2 ENSMUST00000045705.3 ENSMUST00000045705.4 ENSMUST00000045705.5 ENSMUST00000045705.6 ENSMUST00000045705.7 ENSMUST00000045705.8 ENSMUST00000045705.9 Kiaa1736 NM_172669 Q3TF60 Q3U239 Q3UF70 Q6ZPJ1 Q8BJJ8 Q8BYW8 uc008kwu.1 uc008kwu.2 uc008kwu.3 Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:17589504, PubMed:33854232, PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23974797, PubMed:33854232, PubMed:33854235, PubMed:33854239). Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239). By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239). AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25438055). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (By similarity). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:17589504). In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (By similarity). Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (By similarity). The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (PubMed:23974797). In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (By similarity). Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (By similarity). Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947). Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1- mediated ubiquitination of MFN2 (By similarity). AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:28789945, PubMed:30513302). May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (PubMed:28362576). Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (PubMed:32616651). Protein modification; protein ubiquitination. Component of the DCX(AMBRA1) E3 ubiquitin ligase complex, also named CRL4(AMBRA1), at least composed of CUL4 (CUL4A or CUL4B), DDB1, AMBRA1 and RBX1 (PubMed:23974797). Interacts with BECN1 (PubMed:17589504, PubMed:23974797). Probably forms a complex with BECN1 and PIK3C3 (PubMed:17589504). Interacts with BECN2 (By similarity). Interacts with BCL2; leading to prevent interaction with BCN1 and autophagy, interaction is disrupted upon autophagy induction (By similarity). Interacts with ULK1 (By similarity). Interacts (via PxP motifs) with PPP2CA; enhancing interaction between PPP2CA and MYC or FOXO3 (PubMed:25438055). Forms a complex with PPP2CA and BECN1 (By similarity). Interacts (TQT motifs) with DYNLL1 and DYNLL2; tethering AMBRA1 and the BECN1-PIK3C3 complex in absence of autophagy (By similarity). Interacts with TRAF6; interaction is required to mediate 'Lys-63'-linked ubiquitination of ULK1 (By similarity). Interacts with TRIM32; promoting activation of ULK1 by TRIM32 via unanchored 'Lys-63'- linked polyubiquitin chains (By similarity). Interacts with PRKN (PubMed:21753002). Interacts (via LIR motif) with LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C) (By similarity). Interacts with HUWE1 (By similarity). Interacts with PTK2/FAK (PubMed:28362576). Interacts with SRC; required for SRC trafficking to autophagosomes (PubMed:28362576). Endoplasmic reticulum Cytoplasm, cytoskeleton Cytoplasmic vesicle, autophagosome Mitochondrion Cytoplasm, cytosol Nucleus ll junction, focal adhesion Note=Localizes to the cytoskeleton in absence of autophagy induction. Upon autophagy induction, AMBRA1 relocalizes to the endoplasmic reticulum to enable autophagosome nucleation (By similarity). Partially localizes at mitochondria in normal conditions (By similarity). Localizes also to discrete punctae along the ciliary axoneme (PubMed:24089209). Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=A2AH22-1; Sequence=Displayed; Name=2; IsoId=A2AH22-2; Sequence=VSP_030658; Name=3; IsoId=A2AH22-3; Sequence=VSP_030661; Name=4; IsoId=A2AH22-4; Sequence=VSP_030659, VSP_030661; Name=5; IsoId=A2AH22-5; Sequence=VSP_030658, VSP_030659, VSP_030662, VSP_030663; Name=6; IsoId=A2AH22-6; Sequence=VSP_030660; Name=7; IsoId=A2AH22-7; Sequence=VSP_030658, VSP_030659; Expressed throughout the brain, including midbrain and striatum. At 8.5 dpc, it is detected throughout the neuroepithelium (PubMed:17589504). At 11.5 dpc, it is highly expressed in the ventral-most part of the spinal cord, the encephalic vesicles, the neural retina, the limbs and the dorsal root ganglia (PubMed:17589504). Later, it is expressed in the entire developing nervous system as well as in other tissues (PubMed:17589504). In brain, strong expression is observed in the cortex, hippocampus and striatum of postnatal brain (PubMed:17589504). The PxP motifs mediate interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA). The TQT motifs mediate interaction with the dynein light chain proteins DYNLL1 and DYNLL2, tethering AMBRA1 to the cytoskeleton in absence of autophagy. The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins GABARAP and MAP1LC3B. Phosphorylation at Ser-52 by MTOR inhibits its ability to regulate autophagy and mediate ubiquitination of ULK1. Phosphorylation by ULK1 in response to autophagy induction abolishes interaction with DYNLL1 and DYNLL2, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation. Phosphorylation by MTOR inhibits interaction with PPP2CA and subsequent dephosphorylation of MYC. Phosphorylation at Ser-1044 by CHUK/IKKA promotes its interaction with ATG8 family proteins GABARAP and MAP1LC3B and its mitophagic activity. Ubiquitinated by RNF2 via 'Lys-48'-linkage in unstressed cells, leading to its degradation by the proteasome (PubMed:24980959). Induction of autophagy promotes stabilization via interaction with CUL4 (CUL4A or CUL4B) and DDB1. Upon prolonged starvation, ubiquitinated and degraded, terminating the autophagy response (By similarity). Undergoes proteolytic processing by caspase-6 (CASP6), caspase-7 (CASP7) and caspase-8 (CASP8) during apoptosis, resulting in the dismantling of the autophagic machinery and the accomplishment of the programmed cell death program. Also cleaved by calpains during apoptosis, which mediate a complete proteolytic degradation. Embryonic lethality: mice display severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death (PubMed:17589504). Cells show an accumulation of cyclin-D proteins (Ccnd1, Ccnd2 and Ccnd3), correlated with an increase in retinoblastoma (RB) protein family phosphorylation, leading to increased cell proliferation (PubMed:33854232, PubMed:33854235). Conditional knockout mice lacking Ambra1 in the nervous system display an increase in the volume of the cortex and the lateral ventricles, associated with an enhanced rate of proliferation in the whole 13.5 dpc brain and in the olfactory bulbs of the 18.5 dpc brain (PubMed:33854232). Ambra1 deletion in a mouse lung cancer model leads to increased cell proliferation, formation of replication stress and chek1/Chk1 activation; cells are hypersensitive to chek1/Chk1 inhibition (PubMed:33854232). Impaired regulatory T-cells (Treg) differentiation, leading to worsen disease pathogenesis in a mouse model of multiple sclerosis (PubMed:30513302). Belongs to the WD repeat AMBRA1 family. autophagosome assembly mitophagy macromitophagy protein binding cytoplasm mitochondrion autophagosome cytosol axoneme autophagy multicellular organism development nervous system development negative regulation of cell proliferation cellular response to starvation positive regulation of autophagy negative regulation of cardiac muscle cell apoptotic process neural tube development cell differentiation cytoplasmic vesicle ubiquitin protein ligase binding response to nutrient levels negative regulation of neuron apoptotic process positive regulation of phosphatidylinositol 3-kinase activity phagocytic vesicle GTPase binding response to mitochondrial depolarisation uc008kwu.1 uc008kwu.2 uc008kwu.3 
ENSMUST00000045706.12 Cftr ENSMUST00000045706.12 cystic fibrosis transmembrane conductance regulator (from RefSeq NM_021050.2) Abcc7 CFTR_MOUSE ENSMUST00000045706.1 ENSMUST00000045706.10 ENSMUST00000045706.11 ENSMUST00000045706.2 ENSMUST00000045706.3 ENSMUST00000045706.4 ENSMUST00000045706.5 ENSMUST00000045706.6 ENSMUST00000045706.7 ENSMUST00000045706.8 ENSMUST00000045706.9 NM_021050 P26361 Q63893 Q63894 Q9JKQ6 uc009bai.1 uc009bai.2 uc009bai.3 uc009bai.4 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This gene encodes the cystic fibrosis transmembrane regulator and a chloride channel that controls the regulation of other transport pathways. Mutations in this gene have been associated with autosomal recessive disorders such as cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternative splicing of exons 4, 5, and 11 have been observed, but full-length transcripts have not yet been fully described. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M60493.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:20231442, PubMed:22265409). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:21976599). Reaction=ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.; EC=5.6.1.6; Evidence=; Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (PubMed:21976599). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (PubMed:19033647, PubMed:23542070). Interacts with CSE1L (By similarity). The core- glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity). P26361; P70441: Nherf1; NbExp=3; IntAct=EBI-6115317, EBI-1184085; P26361; Q9WVC8: Slc26a3; NbExp=3; IntAct=EBI-6115317, EBI-6895537; P26361; Q8CIW6: Slc26a6; NbExp=3; IntAct=EBI-6115317, EBI-6895517; P26361; P19120: HSPA8; Xeno; NbExp=5; IntAct=EBI-6115317, EBI-907802; Apical cell membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Nucleus Note=The channel is internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane. In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia. In Sertoli cells, a processed product is detected in the nucleus. ER stress induces GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P26361-1; Sequence=Displayed; Name=2; IsoId=P26361-2; Sequence=VSP_000062, VSP_000063; Name=3; IsoId=P26361-3; Sequence=VSP_000064, VSP_000065; Expressed in the epididymis (at protein level) (PubMed:30659401). In the initial segment of the epididymis, detected on both the luminal and basolateral sides of the ducts where it is expressed in the duct columnar cells as well as in the interstitial smooth muscle cells (PubMed:30659401). Expressed in sperm in the caput (PubMed:30659401). In the cauda, detected along the luminal border but not continuously and is also expressed on the basolateral surface (PubMed:30659401). Within the caudal lumen, detected on sperm (PubMed:30659401). Isoform 1: Expressed in a variety of epithelial tissues including colon, kidney, lung, small intestine, pancreatic duct and testis (PubMed:7691356). Isoform 2: Expressed only in testis (PubMed:7691356). Isoform 3: Expressed only in testis (PubMed:7691356). Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains (By similarity). The first ABC transporter nucleotide-binding domain has no ATPase activity by itself (PubMed:14685259, PubMed:15619636). The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, NHERF1/EBP50 complex. The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation. N-glycosylated. Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity. Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity). Mice are born at the expected Mendelian rate, but about 80% die within two to five days after birth due to peritonitis (PubMed:7685652). Those that survive fail to thrive, appear runted and weigh about half as much as wild-type littermates (PubMed:7685652). Many of the surviving pups die when they start ingesting solid food, due to intestinal blockage caused by excessive mucus accumulation (PubMed:7685652). None survive for more than about 45 days after birth (PubMed:7685652). Intestinal crypts in the jejunum and ileum are filled with excessive mucus (PubMed:7685652). Excessive accumulation of mucus is also seen in colon (PubMed:7685652). In contrast, their lungs do not present pathological mucus accumulation (PubMed:7685652). Likewise, only five out of ten animals show dilatation and blockage of several small pancreatic ducts (PubMed:7685652). Besides, mutant mice present defects in their lacrimal glands that make them more susceptible to develop eye infections (PubMed:7685652). In caecum epithelium, forskolin-sensitive ion transport is nearly abolished (PubMed:7685652). Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily. nucleotide binding chloride channel activity channel-conductance-controlling ATPase activity protein binding ATP binding nucleus cytoplasm endosome early endosome endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane integral component of plasma membrane microvillus cholesterol biosynthetic process ion transport chloride transport water transport vesicle docking involved in exocytosis cell surface bicarbonate transmembrane transporter activity chloride transmembrane transporter activity bicarbonate transport iodide transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane isomerase activity ATPase activity chloride channel inhibitor activity enzyme binding PDZ domain binding cholesterol transport transepithelial chloride transport lung development dendrite cytoplasmic vesicle membrane early endosome membrane macromolecular complex positive regulation of mast cell activation chloride channel complex response to endoplasmic reticulum stress transepithelial water transport positive regulation of insulin secretion involved in cellular response to glucose stimulus vasodilation ATPase activity, coupled to transmembrane movement of substances neuronal cell body positive regulation of exocytosis sperm capacitation multicellular organismal water homeostasis chaperone binding intracellular pH elevation recycling endosome recycling endosome membrane transmembrane transport membrane hyperpolarization cellular response to cAMP positive regulation of cyclic nucleotide-gated ion channel activity chloride transmembrane transport positive regulation of voltage-gated chloride channel activity cellular response to forskolin positive regulation of establishment of Sertoli cell barrier negative regulation of vascular associated smooth muscle cell apoptotic process negative regulation of type B pancreatic cell development regulation of membrane depolarization uc009bai.1 uc009bai.2 uc009bai.3 uc009bai.4 
ENSMUST00000045713.4 Nacad ENSMUST00000045713.4 NAC alpha domain containing (from RefSeq NM_001081652.1) ENSMUST00000045713.1 ENSMUST00000045713.2 ENSMUST00000045713.3 Kiaa0363 NACAD_MOUSE NM_001081652 Q5SWP3 Q6I6F5 uc007hyy.1 uc007hyy.2 uc007hyy.3 May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). Cytoplasm Nucleus Belongs to the NAC-alpha family. molecular_function cellular_component nucleus cytoplasm nascent polypeptide-associated complex biological_process protein transport uc007hyy.1 uc007hyy.2 uc007hyy.3 
ENSMUST00000045714.15 Abcg8 ENSMUST00000045714.15 ATP binding cassette subfamily G member 8, transcript variant 3 (from RefSeq NR_104382.1) ABCG8_MOUSE Abcg8 ENSMUST00000045714.1 ENSMUST00000045714.10 ENSMUST00000045714.11 ENSMUST00000045714.12 ENSMUST00000045714.13 ENSMUST00000045714.14 ENSMUST00000045714.2 ENSMUST00000045714.3 ENSMUST00000045714.4 ENSMUST00000045714.5 ENSMUST00000045714.6 ENSMUST00000045714.7 ENSMUST00000045714.8 ENSMUST00000045714.9 NR_104382 Q8R543 Q9DBM0 uc008dta.1 uc008dta.2 uc008dta.3 ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:16352607, PubMed:16867993, PubMed:18402465). Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:12444248, PubMed:14504269, PubMed:14657202, PubMed:25378657). Plays an important role in preventing the accumulation of dietary plant sterols in the body (PubMed:12444248, PubMed:14657202). Required for normal sterol homeostasis (PubMed:12444248, PubMed:14657202). The heterodimer with ABCG5 has ATPase activity (PubMed:16352607, PubMed:16867993). Reaction=ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate; Xref=Rhea:RHEA:39051, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39052; Evidence=; Reaction=ATP + H2O + sitosterol(in) = ADP + H(+) + phosphate + sitosterol(out); Xref=Rhea:RHEA:39103, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27693, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39104; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cholesterol transport is inhibited by vanadate and by beryllium fluoride. Heterodimer with ABCG5. Cell membrane ulti-pass membrane protein Apical cell membrane ulti-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DBM0-1; Sequence=Displayed; Name=2; IsoId=Q9DBM0-2; Sequence=VSP_000053; Detected in liver and jejunum (at protein level) (PubMed:12444248, PubMed:18402465, PubMed:25378657). Expressed in jejunum and ileum and, at lower level, in the liver (PubMed:11907139, PubMed:11099417, PubMed:12444248, PubMed:15040800, PubMed:25378657). Up-regulated in liver and small intestine by cholesterol feeding (PubMed:11099417). Possibly mediated by the liver X receptor/retinoic X receptor (LXR/RXR) pathway. Endotoxin (LPS) significantly decreased mRNA levels in the liver but not in the small intestine (PubMed:12777468). A functional Walker motif (consensus sequence G-X-X-G-X-G-K- [ST]-T) is expected to bind ATP. The essential Lys in this region is not conserved in ABCG8 (G-S-S-G-C-R-A-S) and is not required for transport activity mediated by the heterodimer with ABCG5. N-glycosylated (PubMed:12208867, PubMed:12444248, PubMed:16867993, PubMed:15054092, PubMed:18402465). N-glycosylation is important for efficient export out of the endoplasmic reticulum (PubMed:15054092). Mice are born at the expected Mendelian rate. They display decreased cholesterol levels, but strongly increased levels of the food-derived plant sterols campesterol and beta- sitosterol in blood plasma, liver and spleen (PubMed:25378657). Besides, mutant mice may have slightly increased total plasma triglyceride levels. Expression of Abcg5 is not affected. Mutant mice display decreased biliary sterol secretion (PubMed:15040800). Mice deficient for both Abcg5 and Abcg8 appear healthy and are fertile, but display strongly increased levels of the food-derived plant sterols sitosterol and campesterol in liver and blood plasma (PubMed:12444248, PubMed:14657202, PubMed:25378657). When mice are fed chow containing 0.02% cholesterol, cholesterol levels in blood plasma and in liver are considerably lower than in wild-type (PubMed:12444248, PubMed:14657202). In spite of the increased plasma and liver levels of plant sterols, and the decreased cholesterol levels, the total sterol levels in plasma and liver are closely similar in wild-type and mutant mice (PubMed:14657202). When mice are fed chow containing 2% cholesterol, plasma cholesterol levels remain stable in wild-type, but increase 2.4-fold in mutant mice. In the liver of mice kept on chow containing 2% cholesterol, cholesterol levels increase 3-fold for wild- type mice and 18-fold for mutant mice, resulting in much higher cholesterol levels than in wild-type livers (PubMed:12444248). Dietary cholesterol absorption appears normal in mutant mice, but the absorption of dietary cholestanol, campesterol and sitosterol is increased (PubMed:12444248). At the same time, mutant mice have very low cholesterol levels in bile, suggesting that the increased hepatic cholesterol levels are due to impaired cholesterol secretion into bile (PubMed:12444248). Likewise, the levels of the food-derived plant sterols stigmasterol, sitosterol, campesterol and brassicasterol are strongly decreased in bile from mutant mice (PubMed:14657202). In contrast, biliary phospholipid and bile acid levels appear unchanged relative to wild-type (PubMed:12444248). The blood plasma of mice with liver-specific or intestine-specific disruption of Abcg5 and Abcg8 has nearly normal levels of cholesterol, and mildly increased levels of sitosterol and campesterol (PubMed:25378657). Mice with intestine- specific disruption of Abcg5 and Abcg8 have strongly increased levels of sitosterol and campesterol in enterocytes, similar to that observed for mice with complete gene disruption (PubMed:25378657). In addition, they display strongly increased levels of sitosterol and campesterol in bile (PubMed:25378657). Mice with liver-specific disruption of Abcg5 and Abcg8 have slightly increased levels of campesterol and sitosterol in the liver, and normal, low levels of sitosterol and campesterol in bile (PubMed:25378657). Enterocytes and liver from mice with liver- specific or intestine-specific disruption of Abcg5 and Abcg8 have normal cholesterol levels (PubMed:25378657). Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. Seems to have a defective ATP-binding region. protein binding ATP binding plasma membrane integral component of plasma membrane lipid transport response to nutrient excretion negative regulation of intestinal phytosterol absorption phospholipid transport sterol transport membrane integral component of membrane apical plasma membrane ATPase activity intestinal cholesterol absorption cholesterol efflux response to drug ATPase activity, coupled to transmembrane movement of substances cholesterol homeostasis ATP-binding cassette (ABC) transporter complex receptor complex negative regulation of intestinal cholesterol absorption metal ion binding protein heterodimerization activity transmembrane transport sterol homeostasis uc008dta.1 uc008dta.2 uc008dta.3 
ENSMUST00000045726.8 Rgl3 ENSMUST00000045726.8 ral guanine nucleotide dissociation stimulator-like 3 (from RefSeq NM_023622.4) ENSMUST00000045726.1 ENSMUST00000045726.2 ENSMUST00000045726.3 ENSMUST00000045726.4 ENSMUST00000045726.5 ENSMUST00000045726.6 ENSMUST00000045726.7 NM_023622 Q3UYI5 Q6KAR7 Q8BKD3 Q924M8 Q9DBL8 Q9JID4 RGL3_MOUSE uc009onf.1 uc009onf.2 uc009onf.3 Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1. Interacts with GTP-bound forms of RIT1, HRAS and MRAS. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UYI5-1; Sequence=Displayed; Name=2; IsoId=Q3UYI5-2; Sequence=VSP_028471, VSP_028472, VSP_028473, VSP_028474; Widely expressed. Expressed at high levels in the liver and kidney. The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity. Sequence=BAC35425.1; Type=Frameshift; Evidence=; guanyl-nucleotide exchange factor activity protein binding signal transduction small GTPase mediated signal transduction Ral guanyl-nucleotide exchange factor activity Ras GTPase binding small GTPase binding positive regulation of GTPase activity uc009onf.1 uc009onf.2 uc009onf.3 
ENSMUST00000045736.9 Mroh2b ENSMUST00000045736.9 maestro heat-like repeat family member 2B (from RefSeq NM_001166066.1) A0A096XFP7 A0A096XFP8 ENSMUST00000045736.1 ENSMUST00000045736.2 ENSMUST00000045736.3 ENSMUST00000045736.4 ENSMUST00000045736.5 ENSMUST00000045736.6 ENSMUST00000045736.7 ENSMUST00000045736.8 Heatr7b2 MRO2B_MOUSE Mroh2b NM_001166066 Q7M6Y6 uc011zqx.1 uc011zqx.2 uc011zqx.3 uc011zqx.4 May play a role in the process of sperm capacitation (PubMed:27105888). Found in a complex at least composed of MROH2B isoform 2, PRKACA isoform 2 and TCP11 (PubMed:27105888). Interacts with PRKACA isoform 2 (PubMed:27105888). Interacts with TCP11 (PubMed:27105888). Cytoplasm Cytoplasmic vesicle, secretory vesicle, acrosome Cell projection, cilium, flagellum Note=Colocalizes with PRKACA and TCP11 on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7M6Y6-1; Sequence=Displayed; Name=2; Synonyms=SPIF-L ; IsoId=Q7M6Y6-2; Sequence=VSP_058722; Name=3; Synonyms=SPIF-S ; IsoId=Q7M6Y6-3; Sequence=VSP_058721; Expressed strongly in round spermatids and fully mature spermatozoa. Expressed weakly in pachytene spermatocytes (at protein level). Isoform 2 is specifically expressed in the testis. Isoform 2 is expressed in pachytene spermatocytes and round spermatids. Isoform 3 is weakly expressed in testis. Constitutively phosphorylated on serine and threonine residues in acrosomal region of the sperm head, midpiece and flagellar regions of noncapacitated spermatozoa. Phosphorylation on tyrosine residues increases upon sperm capacitation within the acrosomal and tail regions in a protein kinase A (PKA)-dependent signaling pathway. Embryonically lethal before 10 dpc. Sequence=DAA01465.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; acrosomal vesicle protein binding cytoplasm cilium spermatogenesis protein kinase A signaling cell differentiation cytoplasmic vesicle motile cilium sperm flagellum cell projection sperm midpiece uc011zqx.1 uc011zqx.2 uc011zqx.3 uc011zqx.4 
ENSMUST00000045737.14 Galnt11 ENSMUST00000045737.14 polypeptide N-acetylgalactosaminyltransferase 11, transcript variant 1 (from RefSeq NM_144908.4) ENSMUST00000045737.1 ENSMUST00000045737.10 ENSMUST00000045737.11 ENSMUST00000045737.12 ENSMUST00000045737.13 ENSMUST00000045737.2 ENSMUST00000045737.3 ENSMUST00000045737.4 ENSMUST00000045737.5 ENSMUST00000045737.6 ENSMUST00000045737.7 ENSMUST00000045737.8 ENSMUST00000045737.9 GLT11_MOUSE NM_144908 Q3TT83 Q8BU26 Q8K032 Q921L8 uc008wss.1 uc008wss.2 uc008wss.3 Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O- glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO) (By similarity). Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Interacts with NOTCH1. Golgi apparatus membrane ; Single- pass type II membrane protein Mainly expressed in kidney. Weakly expressed in other tissues. At 8.0 dpc, present in the left-right organiser (LRO) node, with enrichment in crown cells compared to pit cells (at protein level). There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Sequence=AAH34184.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Name=Functional Glycomics Gateway - GTase; Note=Polypeptide N-acetylgalactosaminyltransferase 11; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_519"; Golgi membrane polypeptide N-acetylgalactosaminyltransferase activity Notch binding Golgi apparatus protein glycosylation Notch signaling pathway Notch receptor processing determination of left/right symmetry regulation of Notch signaling pathway membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via threonine carbohydrate binding metal ion binding cilium assembly Notch signaling involved in heart development uc008wss.1 uc008wss.2 uc008wss.3 
ENSMUST00000045738.5 Slc32a1 ENSMUST00000045738.5 solute carrier family 32 (GABA vesicular transporter), member 1, transcript variant 1 (from RefSeq NM_009508.3) ENSMUST00000045738.1 ENSMUST00000045738.2 ENSMUST00000045738.3 ENSMUST00000045738.4 NM_009508 Q49S98 Q49S98_MOUSE Slc32a1 Viaat uc008nqk.1 uc008nqk.2 uc008nqk.3 Reaction=4-aminobutanoate(out) + n H(+)(in) = 4-aminobutanoate(in) + n H(+)(out); Xref=Rhea:RHEA:70979, ChEBI:CHEBI:15378, ChEBI:CHEBI:59888; Evidence=; Reaction=beta-alanine(out) + n H(+)(in) = beta-alanine(in) + n H(+)(out); Xref=Rhea:RHEA:70987, ChEBI:CHEBI:15378, ChEBI:CHEBI:57966; Evidence=; Reaction=glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out); Xref=Rhea:RHEA:70983, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305; Evidence=; Membrane ; Multi- pass membrane protein Presynapse Belongs to the amino acid/polyamine transporter 2 family. aging synaptic vesicle gamma-aminobutyric acid transport membrane integral component of membrane hippocampus development integral component of synaptic vesicle membrane dendrite neuron projection intracellular organelle neuron projection terminus synapse inhibitory synapse neurotransmitter loading into synaptic vesicle GABA-ergic synapse uc008nqk.1 uc008nqk.2 uc008nqk.3 
ENSMUST00000045740.8 Zxdc ENSMUST00000045740.8 Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. (from UniProt Q8C8V1) AK169517 ENSMUST00000045740.1 ENSMUST00000045740.2 ENSMUST00000045740.3 ENSMUST00000045740.4 ENSMUST00000045740.5 ENSMUST00000045740.6 ENSMUST00000045740.7 Q3TEP2 Q3URC2 Q8C4U7 Q8C4Z9 Q8C8C2 Q8C8T1 Q8C8V1 Q99J65 ZXDC_MOUSE uc291han.1 uc291han.2 Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. Self-associates. Interacts with ZXDB and CIITA (By similarity). Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8C8V1-1; Sequence=Displayed; Name=2; IsoId=Q8C8V1-2; Sequence=VSP_026443, VSP_026444; Name=3; IsoId=Q8C8V1-3; Sequence=VSP_026441, VSP_026442; Name=4; IsoId=Q8C8V1-4; Sequence=VSP_026439, VSP_026440; Sumoylated at Lys-661 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional activation domain. Belongs to the ZXD family. Sequence=AAH03332.1; Type=Frameshift; Evidence=; Sequence=BAC31967.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC33082.1; Type=Frameshift; Evidence=; Sequence=BAC38113.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleic acid binding transcription factor activity, sequence-specific DNA binding cellular_component nucleus LRR domain binding positive regulation of transcription, DNA-templated metal ion binding C2H2 zinc finger domain binding uc291han.1 uc291han.2 
ENSMUST00000045743.13 Prkab2 ENSMUST00000045743.13 protein kinase, AMP-activated, beta 2 non-catalytic subunit (from RefSeq NM_182997.2) AAKB2_MOUSE ENSMUST00000045743.1 ENSMUST00000045743.10 ENSMUST00000045743.11 ENSMUST00000045743.12 ENSMUST00000045743.2 ENSMUST00000045743.3 ENSMUST00000045743.4 ENSMUST00000045743.5 ENSMUST00000045743.6 ENSMUST00000045743.7 ENSMUST00000045743.8 ENSMUST00000045743.9 NM_182997 Q6PAM0 uc008qpb.1 uc008qpb.2 uc008qpb.3 uc008qpb.4 Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C- terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. Belongs to the 5'-AMP-activated protein kinase beta subunit family. AMP-activated protein kinase activity nucleus nucleoplasm cytoplasm cytosol cAMP-dependent protein kinase complex protein phosphorylation lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process apical plasma membrane enzyme binding protein kinase binding nucleotide-activated protein kinase complex identical protein binding regulation of catalytic activity uc008qpb.1 uc008qpb.2 uc008qpb.3 uc008qpb.4 
ENSMUST00000045747.5 Wnt4 ENSMUST00000045747.5 wingless-type MMTV integration site family, member 4 (from RefSeq NM_009523.2) ENSMUST00000045747.1 ENSMUST00000045747.2 ENSMUST00000045747.3 ENSMUST00000045747.4 NM_009523 Q3ZB23 Q3ZB23_MOUSE Wnt4 uc008viv.1 uc008viv.2 uc008viv.3 uc008viv.4 Ligand for members of the frizzled family of seven transmembrane receptors. Secreted, extracellular space, extracellular matrix Belongs to the Wnt family. kidney development epithelial to mesenchymal transition liver development receptor binding extracellular region extracellular space cytoplasm multicellular organism development male gonad development negative regulation of gene expression negative regulation of steroid biosynthetic process Wnt signaling pathway female sex determination adrenal gland development positive regulation of bone mineralization positive regulation of aldosterone biosynthetic process positive regulation of collagen biosynthetic process non-canonical Wnt signaling pathway via MAPK cascade positive regulation of osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated receptor agonist activity canonical Wnt signaling pathway mammary gland epithelium development positive regulation of dermatome development paramesonephric duct development negative regulation of testicular blood vessel morphogenesis cellular response to transforming growth factor beta stimulus negative regulation of male gonad development positive regulation of cortisol biosynthetic process negative regulation of androgen biosynthetic process negative regulation of testosterone biosynthetic process uc008viv.1 uc008viv.2 uc008viv.3 uc008viv.4 
ENSMUST00000045748.7 Pdk3 ENSMUST00000045748.7 pyruvate dehydrogenase kinase, isoenzyme 3 (from RefSeq NM_145630.3) ENSMUST00000045748.1 ENSMUST00000045748.2 ENSMUST00000045748.3 ENSMUST00000045748.4 ENSMUST00000045748.5 ENSMUST00000045748.6 NM_145630 PDK3_MOUSE Q8BTX1 Q922H2 uc009tsx.1 uc009tsx.2 uc009tsx.3 Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species (By similarity). Reaction=ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]; Xref=Rhea:RHEA:23052, Rhea:RHEA-COMP:13689, Rhea:RHEA-COMP:13690, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.2; Homodimer. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3) (By similarity). Mitochondrion matrix Belongs to the PDK/BCKDK protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity pyruvate dehydrogenase (acetyl-transferring) kinase activity ATP binding nucleolus mitochondrion mitochondrial matrix carbohydrate metabolic process glucose metabolic process regulation of acetyl-CoA biosynthetic process from pyruvate regulation of glucose metabolic process kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peroxisome proliferator activated receptor signaling pathway cellular response to glucose stimulus cellular response to fatty acid hypoxia-inducible factor-1alpha signaling pathway regulation of reactive oxygen species metabolic process uc009tsx.1 uc009tsx.2 uc009tsx.3 
ENSMUST00000045756.14 S100a10 ENSMUST00000045756.14 S100 calcium binding protein A10 (calpactin) (from RefSeq NM_009112.2) ENSMUST00000045756.1 ENSMUST00000045756.10 ENSMUST00000045756.11 ENSMUST00000045756.12 ENSMUST00000045756.13 ENSMUST00000045756.2 ENSMUST00000045756.3 ENSMUST00000045756.4 ENSMUST00000045756.5 ENSMUST00000045756.6 ENSMUST00000045756.7 ENSMUST00000045756.8 ENSMUST00000045756.9 NM_009112 Q3TC45 Q3TC45_MOUSE S100a10 uc008qfk.1 uc008qfk.2 uc008qfk.3 Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. Belongs to the S-100 family. membrane raft assembly calcium ion binding endoplasmic reticulum membrane budding membrane integral component of membrane response to drug protein homodimerization activity positive regulation of GTPase activity ion channel binding membrane raft protein heterotetramerization positive regulation of stress fiber assembly positive regulation of focal adhesion assembly protein localization to plasma membrane positive regulation of substrate adhesion-dependent cell spreading uc008qfk.1 uc008qfk.2 uc008qfk.3 
ENSMUST00000045761.7 Lzts3 ENSMUST00000045761.7 leucine zipper, putative tumor suppressor family member 3, transcript variant 1 (from RefSeq NM_197945.4) A2AHF9 A2AHG0 ENSMUST00000045761.1 ENSMUST00000045761.2 ENSMUST00000045761.3 ENSMUST00000045761.4 ENSMUST00000045761.5 ENSMUST00000045761.6 LZTS3_MOUSE Lzts3 NM_197945 Prosapip1 Q3TSY0 Q6PE51 uc012ceh.1 uc012ceh.2 uc012ceh.3 uc012ceh.4 May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses. Interacts (via C-terminus) with SHANK3 (via PDZ domain). Interacts (via coiled coil) with SIPA1L1. Can form homooligomers. Synapse Postsynaptic density Cell projection, dendritic spine Cell projection, dendrite Cytoplasm, cytoskeleton Note=Rather found at excitatory than inhibitory synapses. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AHG0-1; Sequence=Displayed; Name=2; IsoId=A2AHG0-2; Sequence=VSP_039203; Name=3; IsoId=A2AHG0-3; Sequence=VSP_039204, VSP_039205; Belongs to the LZTS3 family. Sequence=AAH58280.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cytoplasm cytoskeleton plasma membrane postsynaptic density membrane cell junction PDZ domain binding dendritic spine protein self-association synapse postsynaptic membrane protein homooligomerization regulation of dendritic spine morphogenesis uc012ceh.1 uc012ceh.2 uc012ceh.3 uc012ceh.4 
ENSMUST00000045766.8 Wdr70 ENSMUST00000045766.8 WD repeat domain 70, transcript variant 1 (from RefSeq NM_001081402.1) ENSMUST00000045766.1 ENSMUST00000045766.2 ENSMUST00000045766.3 ENSMUST00000045766.4 ENSMUST00000045766.5 ENSMUST00000045766.6 ENSMUST00000045766.7 G3X934 G3X934_MOUSE NM_001081402 Wdr70 uc007veg.1 uc007veg.2 uc007veg.3 Belongs to the WD repeat GAD-1 family. enzyme binding uc007veg.1 uc007veg.2 uc007veg.3 
ENSMUST00000045771.7 Spem1 ENSMUST00000045771.7 spermatid maturation 1 (from RefSeq NM_028855.1) ENSMUST00000045771.1 ENSMUST00000045771.2 ENSMUST00000045771.3 ENSMUST00000045771.4 ENSMUST00000045771.5 ENSMUST00000045771.6 NM_028855 Q497J9 Q5F289 Q9D9D4 SPEM1_MOUSE uc007jrv.1 uc007jrv.2 uc007jrv.3 Required for proper cytoplasm removal during spermatogenesis. Membrane ; Single-pass membrane protein Cytoplasm Testis-specific. Exclusively present in cytoplasm of steps 14-16 elongated spermatids (at protein level). Mice are completely infertile because of deformed sperm characterized by a bent head wrapped around by the neck and the middle piece of the tail. Lack of Spem1 causes failure of the cytoplasm to become loose and detach from the head and the neck region of the developing spermatozoa. cytoplasm multicellular organism development spermatogenesis sperm individualization membrane integral component of membrane cell differentiation flagellated sperm motility uc007jrv.1 uc007jrv.2 uc007jrv.3 
ENSMUST00000045776.5 AI182371 ENSMUST00000045776.5 expressed sequence AI182371, transcript variant 1 (from RefSeq NM_178885.5) A2AS37 A2AS37_MOUSE AI182371 ENSMUST00000045776.1 ENSMUST00000045776.2 ENSMUST00000045776.3 ENSMUST00000045776.4 NM_178885 uc008jjq.1 uc008jjq.2 uc008jjq.3 Secreted protease binding endopeptidase inhibitor activity extracellular region extracellular space inflammatory response complement activation negative regulation of endopeptidase activity uc008jjq.1 uc008jjq.2 uc008jjq.3 
ENSMUST00000045779.6 Ttyh2 ENSMUST00000045779.6 tweety family member 2 (from RefSeq NM_053273.2) ENSMUST00000045779.1 ENSMUST00000045779.2 ENSMUST00000045779.3 ENSMUST00000045779.4 ENSMUST00000045779.5 NM_053273 Q3TH73 Q3U103 Q3U8L3 Q6P9J3 Q920A8 TTYH2_MOUSE uc007mfm.1 uc007mfm.2 uc007mfm.3 Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation (By similarity). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TH73-1; Sequence=Displayed; Name=2; IsoId=Q3TH73-2; Sequence=VSP_029768; Belongs to the tweety family. intracellular calcium activated chloride channel activity chloride channel activity plasma membrane ion transport chloride transport membrane integral component of membrane ion transmembrane transport chloride channel complex volume-sensitive chloride channel activity chloride transmembrane transport uc007mfm.1 uc007mfm.2 uc007mfm.3 
ENSMUST00000045788.9 Macroh2a1 ENSMUST00000045788.9 macroH2A.1 histone, transcript variant 4 (from RefSeq NM_001159515.1) ENSMUST00000045788.1 ENSMUST00000045788.2 ENSMUST00000045788.3 ENSMUST00000045788.4 ENSMUST00000045788.5 ENSMUST00000045788.6 ENSMUST00000045788.7 ENSMUST00000045788.8 H2AY_MOUSE H2afy Macroh2a1 NM_001159515 Q91VZ2 Q9QZQ7 Q9QZQ8 uc007qsg.1 uc007qsg.2 uc007qsg.3 uc007qsg.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Involved in stable X chromosome inactivation (By similarity). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (By similarity). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16107708). [Isoform 1]: Isoform that specifically binds poly-ADP-ribose and O-acetyl-ADP-ribose and plays a key role in NAD(+) metabolism (PubMed:28991266, PubMed:34887560). Able to bind to the ends of poly- ADP-ribose chains created by PARP1 and cap them (PubMed:28991266). This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration (PubMed:28991266). Increases the expression of genes involved in redox metabolism, including SOD3 (PubMed:23022728). [Isoform 2]: In contrast to isoform 1, does not bind poly- ADP-ribose (By similarity). Represses SOD3 gene expression (PubMed:23022728). The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with HDAC1 and HDAC2. Interacts with SPOP. Part of a complex consisting of MACROH2A1, CUL3 and SPOP. [Isoform 1]: Interacts with PARP1. Nucleus romosome te=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin (PubMed:9634239). In quiescent lymphocytes, associated with centromeric constitutive heterochromatin (PubMed:15564378). Recruited to DNA damage sites in an APLF-dependent manner (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=mH2A1.1 , macroH2A1.1 ; IsoId=Q9QZQ8-2; Sequence=Displayed; Name=2; Synonyms=mH2A1.2 , macroH2A1.2 ; IsoId=Q9QZQ8-1; Sequence=VSP_061611; Widely expressed, with high levels in testis. Present in liver, kidney and adrenal gland (at protein level). In the liver, present in hepatocytes and at a lesser extent in cells of the bile ducts. In the kidney, expressed in proximal and distal convoluted tubules and in straight proximal tubules. In the adrenal gland, present in inner cells of the cortex and medulla. [Isoform 1]: The macro domain specifically binds poly-ADP- ribose (PubMed:28991266, PubMed:34887560). Binds poly-ADP-ribose with lower affinity compared to premetazoan macroH2A1.1 ortholog (PubMed:34887560). Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin. [Isoform 2]: Major form. The preferential expression of isoform 2 over that of isoform 1 requires the presence of DDX5/DDX17. [Isoform 1]: Preferentially expressed over isoform 2 in the absence of DDX5/DDX17. Belongs to the histone H2A family. negative regulation of transcription from RNA polymerase II promoter rDNA binding nuclear chromosome chromatin nucleosome nuclear chromatin condensed chromosome RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding Barr body DNA binding chromatin binding nucleus chromosome pericentric heterochromatin nucleolus centrosome chromatin organization nucleosome assembly dosage compensation double-stranded methylated DNA binding regulation of lipid metabolic process enzyme binding protein kinase binding protein serine/threonine kinase inhibitor activity chromatin DNA binding nucleosomal DNA binding negative regulation of histone phosphorylation positive regulation of maintenance of mitotic sister chromatid cohesion regulation of gene expression, epigenetic transcription regulatory region DNA binding positive regulation of keratinocyte differentiation negative regulation of gene expression, epigenetic positive regulation of gene expression, epigenetic protein heterodimerization activity negative regulation of histone H3-K4 methylation negative regulation of histone H3-K27 methylation establishment of protein localization to chromatin negative regulation of protein serine/threonine kinase activity negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter negative regulation of cell cycle G2/M phase transition regulation of response to oxidative stress negative regulation of response to oxidative stress positive regulation of response to oxidative stress negative regulation of protein localization to chromosome, telomeric region promoter-specific chromatin binding uc007qsg.1 uc007qsg.2 uc007qsg.3 uc007qsg.4 
ENSMUST00000045791.11 Scamp2 ENSMUST00000045791.11 secretory carrier membrane protein 2, transcript variant 2 (from RefSeq NM_022813.3) ENSMUST00000045791.1 ENSMUST00000045791.10 ENSMUST00000045791.2 ENSMUST00000045791.3 ENSMUST00000045791.4 ENSMUST00000045791.5 ENSMUST00000045791.6 ENSMUST00000045791.7 ENSMUST00000045791.8 ENSMUST00000045791.9 NM_022813 Q9ERN0 SCAM2_MOUSE uc009pve.1 uc009pve.2 uc009pve.3 uc009pve.4 Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface (By similarity). Interacts with SLC6A4 and SLC9A7. Interacts with SLC9A5; this interaction regulates SLC9A5 cell-surface targeting and SLC9A5 activity. Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Belongs to the SCAMP family. Golgi membrane endosome Golgi apparatus protein transport membrane integral component of membrane transport vesicle trans-Golgi network membrane intracellular membrane-bounded organelle recycling endosome membrane uc009pve.1 uc009pve.2 uc009pve.3 uc009pve.4 
ENSMUST00000045793.15 Rnf38 ENSMUST00000045793.15 ring finger protein 38, transcript variant 5 (from RefSeq NM_001379575.1) ENSMUST00000045793.1 ENSMUST00000045793.10 ENSMUST00000045793.11 ENSMUST00000045793.12 ENSMUST00000045793.13 ENSMUST00000045793.14 ENSMUST00000045793.2 ENSMUST00000045793.3 ENSMUST00000045793.4 ENSMUST00000045793.5 ENSMUST00000045793.6 ENSMUST00000045793.7 ENSMUST00000045793.8 ENSMUST00000045793.9 NM_001379575 Q3UH35 Q3UH35_MOUSE Rnf38 uc008srs.1 uc008srs.2 uc008srs.3 uc008srs.4 uc008srs.1 uc008srs.2 uc008srs.3 uc008srs.4 
ENSMUST00000045802.7 Pclaf ENSMUST00000045802.7 PCNA clamp associated factor (from RefSeq NM_026515.2) ENSMUST00000045802.1 ENSMUST00000045802.2 ENSMUST00000045802.3 ENSMUST00000045802.4 ENSMUST00000045802.5 ENSMUST00000045802.6 NM_026515 Ns5atp9 PAF15_MOUSE Paf Pclaf Q4VAG2 Q9CQX4 Q9CZ17 Q9D0A5 uc009qeb.1 uc009qeb.2 uc009qeb.3 PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork- blocking lesions. Also acts as a regulator of centrosome number (By similarity). Interacts (when monoubiquitinated at Lys-15 and Lys-24) with PCNA. Interacts with isoform 2/p33ING1b of ING1. Interacts with BRCA1 (By similarity). Nucleus Cytoplasm, perinuclear region Note=Following DNA damage, localizes to DNA damage sites. Colocalizes with centrosomes in perinuclear region. The PIP-box mediates the interaction with PCNA. The KEN box is required for the association with the APC/C complex. The D-box (destruction box) mediates the interaction with APC/C proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway. The initiation motif is required for efficient chain initiation by the APC/C complex E2 ligase UBE2C. It determines the rate of substrate's degradation without affecting its affinity for the APC/C, a mechanism used by the APC/C to control the timing of substrate proteolysis during the cell cycle (By similarity). Monoubiquitinated at Lys-15 and Lys-24 during normal S phase, promoting its association with PCNA. Also diubiquitinated at these 2 sites. Following DNA damage, monoubiquitin chains at Lys-15 and Lys-24 are probably extended, leading to disrupt the interaction with PCNA. Polyubiquitinated by the APC/C complex at the mitotic exit, leading to its degradation by the proteasome (By similarity). chromatin binding nucleus cytoplasm centrosome DNA replication DNA repair cellular response to DNA damage stimulus centrosome cycle response to UV translesion synthesis perinuclear region of cytoplasm regulation of cell cycle uc009qeb.1 uc009qeb.2 uc009qeb.3 
ENSMUST00000045807.14 Tsr1 ENSMUST00000045807.14 TSR1 20S rRNA accumulation (from RefSeq NM_177325.3) ENSMUST00000045807.1 ENSMUST00000045807.10 ENSMUST00000045807.11 ENSMUST00000045807.12 ENSMUST00000045807.13 ENSMUST00000045807.2 ENSMUST00000045807.3 ENSMUST00000045807.4 ENSMUST00000045807.5 ENSMUST00000045807.6 ENSMUST00000045807.7 ENSMUST00000045807.8 ENSMUST00000045807.9 Kiaa1401 NM_177325 Q3TMW6 Q3TRK6 Q3U4T2 Q3UYU4 Q3V3X8 Q5SWD9 Q6ZPR9 Q8K2F5 TSR1_MOUSE uc007kco.1 uc007kco.2 uc007kco.3 Required during maturation of the 40S ribosomal subunit in the nucleolus. Nucleus, nucleolus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5SWD9-1; Sequence=Displayed; Name=2; IsoId=Q5SWD9-2; Sequence=VSP_029504; Name=3; IsoId=Q5SWD9-3; Sequence=VSP_029505, VSP_029506; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily. Sequence=AAH31531.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH31531.1; Type=Frameshift; Evidence=; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GTPase activity GTP binding nucleus nucleolus preribosome, small subunit precursor U3 snoRNA binding ribosome biogenesis uc007kco.1 uc007kco.2 uc007kco.3 
ENSMUST00000045810.15 Zfp446 ENSMUST00000045810.15 zinc finger protein 446, transcript variant 1 (from RefSeq NM_175558.5) ENSMUST00000045810.1 ENSMUST00000045810.10 ENSMUST00000045810.11 ENSMUST00000045810.12 ENSMUST00000045810.13 ENSMUST00000045810.14 ENSMUST00000045810.2 ENSMUST00000045810.3 ENSMUST00000045810.4 ENSMUST00000045810.5 ENSMUST00000045810.6 ENSMUST00000045810.7 ENSMUST00000045810.8 ENSMUST00000045810.9 NM_175558 Q8C9M8 Q8C9M8_MOUSE Zfp446 uc009feu.1 uc009feu.2 uc009feu.3 uc009feu.4 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated identical protein binding metal ion binding uc009feu.1 uc009feu.2 uc009feu.3 uc009feu.4 
ENSMUST00000045817.14 Kirrel2 ENSMUST00000045817.14 kirre like nephrin family adhesion molecule 2 (from RefSeq NM_172898.3) ENSMUST00000045817.1 ENSMUST00000045817.10 ENSMUST00000045817.11 ENSMUST00000045817.12 ENSMUST00000045817.13 ENSMUST00000045817.2 ENSMUST00000045817.3 ENSMUST00000045817.4 ENSMUST00000045817.5 ENSMUST00000045817.6 ENSMUST00000045817.7 ENSMUST00000045817.8 ENSMUST00000045817.9 KIRR2_MOUSE NM_172898 Neph3 Q7TQ98 Q7TSU7 uc009gel.1 uc009gel.2 uc009gel.3 May regulate basal insulin secretion. Homodimer (PubMed:26324709). Interacts with NPHS2/podocin (via the C-terminus). Interacts with NPHS1 (via the Ig-like domains). Interacts with FYN (PubMed:26324709). Cell membrane ; Single-pass type I membrane protein Note=Localized along the sites of the cell contacts (PubMed:26324709). Colocalizes with E- Cadherin and beta-catenin (PubMed:26324709). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TSU7-1; Sequence=Displayed; Name=2; IsoId=Q7TSU7-2; Sequence=VSP_011786; Highly expressed in beta-cells of the pancreatic islets. Expression is seen in podocytes of kidney glomeruli, and in the cerebellum and hindbrain at 12.5 dpc, in the spinal cord at 10.5 dpc, and in retina and hypothalamus at 13.5 dpc. N-glycosylated. Phosphorylated at Ser-548 or Ser-549; due to site ambiguity, the exact position of the serine phosphorylation could not be determined. Phosphorylation at residues Tyr-631 and/or Tyr-632. FYN mediates tyrosine phosphorylation in pancreatic beta-cells. The extracellular domain is cleaved leading to the generation of a soluble fragment and a membrane-bound C-terminal fragment, which is further cleaved by gamma-secretase. No visible phenotype. However basal insulin secretion is modestly increased in pancreatic islets of KIRREL2 deficient mice. Belongs to the immunoglobulin superfamily. negative regulation of protein phosphorylation protein binding plasma membrane cell-cell junction membrane integral component of membrane slit diaphragm identical protein binding cell-cell adhesion uc009gel.1 uc009gel.2 uc009gel.3 
ENSMUST00000045827.5 Mtrr ENSMUST00000045827.5 5-methyltetrahydrofolate-homocysteine methyltransferase reductase, transcript variant 2 (from RefSeq NM_172480.4) A0A0R4J0G9 A0A0R4J0G9_MOUSE ENSMUST00000045827.1 ENSMUST00000045827.2 ENSMUST00000045827.3 ENSMUST00000045827.4 Mtrr NM_172480 uc007rby.1 uc007rby.2 uc007rby.3 uc007rby.4 Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Mutations in a similar gene in human have been associated with cblE complementation type homocystinuria-megaloblastic anemia and susceptibility to folate-sensitive neural tube defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2015]. Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; NADPH-hemoprotein reductase activity methionine biosynthetic process FMN binding oxidoreductase activity oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [methionine synthase] reductase activity homocysteine catabolic process folic acid metabolic process aquacobalamin reductase (NADPH) activity flavin adenine dinucleotide binding oxidation-reduction process NADPH binding FAD binding negative regulation of cystathionine beta-synthase activity uc007rby.1 uc007rby.2 uc007rby.3 uc007rby.4 
ENSMUST00000045840.5 Gpr26 ENSMUST00000045840.5 G protein-coupled receptor 26 (from RefSeq NM_173410.3) ENSMUST00000045840.1 ENSMUST00000045840.2 ENSMUST00000045840.3 ENSMUST00000045840.4 GPR26_MOUSE NM_173410 Q80T55 Q8BXZ5 Q8BZA7 uc009kbs.1 uc009kbs.2 uc009kbs.3 Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP (By similarity). Cell membrane; Multi-pass membrane protein. Exclusively expressed in the brain. Prominent expression is detected throughout the entire neocortex at all rostrocaudal and dorsoventral levels. Strong expression is detected in olfactory and auditory sensory areas. At 14.5 dpc, expression is limited to the developing nervous system with strong expression in the developing cortex, midbrain, cerebellum and medulla. Weaker expression is also detected in the trigeminal ganglion. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway membrane integral component of membrane uc009kbs.1 uc009kbs.2 uc009kbs.3 
ENSMUST00000045846.12 Sfxn5 ENSMUST00000045846.12 sideroflexin 5 (from RefSeq NM_178639.4) ENSMUST00000045846.1 ENSMUST00000045846.10 ENSMUST00000045846.11 ENSMUST00000045846.2 ENSMUST00000045846.3 ENSMUST00000045846.4 ENSMUST00000045846.5 ENSMUST00000045846.6 ENSMUST00000045846.7 ENSMUST00000045846.8 ENSMUST00000045846.9 NM_178639 Q8BGG3 Q925N0 SFXN5_MOUSE Sfxn5 uc009cpj.1 uc009cpj.2 uc009cpj.3 uc009cpj.4 Mitochondrial amino-acid transporter (By similarity). Transports citrate (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity). In brown adipose tissue, plays a role in the regulation of UCP1-dependent thermogenesis probably by supporting mitochondrial glycerol-3-phosphate utilization (PubMed:36334589). Reaction=citrate(in) = citrate(out); Xref=Rhea:RHEA:33183, ChEBI:CHEBI:16947; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Expressed in liver and brain. Expressed in brown adipose tissue (PubMed:36334589). In brown adipose tissue, expression is induced by cold. Knockdown in brown adipose tissue attenuates whole-body thermogenic responses upon exposure to cold. Brown adipocytes show decreased glycerol-3-phosphate levels in mitochondria. Belongs to the sideroflexin family. mitochondrion mitochondrial inner membrane ion transport amino acid transport ion transmembrane transporter activity citrate transmembrane transporter activity citrate transport membrane integral component of membrane mitochondrial membrane ion transmembrane transport transmembrane transport uc009cpj.1 uc009cpj.2 uc009cpj.3 uc009cpj.4 
ENSMUST00000045847.15 Erf ENSMUST00000045847.15 Ets2 repressor factor, transcript variant 2 (from RefSeq NM_010155.4) A0A0R4J0I0 A0A0R4J0I0_MOUSE ENSMUST00000045847.1 ENSMUST00000045847.10 ENSMUST00000045847.11 ENSMUST00000045847.12 ENSMUST00000045847.13 ENSMUST00000045847.14 ENSMUST00000045847.2 ENSMUST00000045847.3 ENSMUST00000045847.4 ENSMUST00000045847.5 ENSMUST00000045847.6 ENSMUST00000045847.7 ENSMUST00000045847.8 ENSMUST00000045847.9 Erf NM_010155 uc009frz.1 uc009frz.2 uc009frz.3 uc009frz.4 Nucleus Belongs to the ETS family. negative regulation of transcription from RNA polymerase II promoter DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity nucleus nucleoplasm cytosol regulation of transcription, DNA-templated sequence-specific DNA binding uc009frz.1 uc009frz.2 uc009frz.3 uc009frz.4 
ENSMUST00000045855.9 Hebp1 ENSMUST00000045855.9 heme binding protein 1 (from RefSeq NM_013546.3) A0A140T8J4 A0A140T8J4_MOUSE ENSMUST00000045855.1 ENSMUST00000045855.2 ENSMUST00000045855.3 ENSMUST00000045855.4 ENSMUST00000045855.5 ENSMUST00000045855.6 ENSMUST00000045855.7 ENSMUST00000045855.8 Hebp1 NM_013546 uc009elh.1 uc009elh.2 uc009elh.3 May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities. Monomer. Cytoplasm Belongs to the HEBP family. uc009elh.1 uc009elh.2 uc009elh.3 
ENSMUST00000045866.9 Ddx21 ENSMUST00000045866.9 DExD box helicase 21 (from RefSeq NM_019553.2) DDX21_MOUSE ENSMUST00000045866.1 ENSMUST00000045866.2 ENSMUST00000045866.3 ENSMUST00000045866.4 ENSMUST00000045866.5 ENSMUST00000045866.6 ENSMUST00000045866.7 ENSMUST00000045866.8 NM_019553 Q3TVJ3 Q9JIK5 Q9WV45 uc007fhn.1 uc007fhn.2 uc007fhn.3 RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (By similarity). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (By similarity). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification (By similarity). Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre- ribosomal complexes (By similarity). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (By similarity). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (By similarity). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single- stranded RNA (foldase) (By similarity). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (By similarity). Involved in rRNA processing. May bind to specific miRNA hairpins (By similarity). Component of a multi-helicase- TICAM1 complex that acts as a cytoplasmic sensor of viral double- stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (PubMed:21703541). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Acetylation inhibits the helicase activity. Homodimer; homodimerizes via its N-terminus (PubMed:21703541). Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this complex exists in resting cells with or without poly(I:C) RNA ligand stimulation (PubMed:21703541). Interacts (via C-terminus) with TICAM1 (via TIR domain) (PubMed:21703541). Interacts with DHX36 (via C-terminus); this interaction serves as bridges to TICAM1 (PubMed:21703541). Interacts (via C-terminus) with DDX1 (via B30.2/SPRY domain); this interaction serves as bridges to TICAM1 (PubMed:21703541). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts with C1QBP. Interacts with JUN. Interacts with WDR46. Interacts with MCM3AP (By similarity). Interacts with WDR43 (PubMed:31128943). Interacts with KPNA3 (By similarity). Nucleus, nucleolus Nucleus, nucleoplasm Cytoplasm, cytosol Mitochondrion Note=Present both in nucleolus and nucleoplasm. Interaction with JUN promotes translocation from the nucleolus to the nucleoplasm. Interaction with WDR46 is required for localization to the nucleolus. Colocalizes in the cytosol with DDX1, DHX36 and TICAM1 (PubMed:21703541). The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA ligand stimulation (PubMed:21703541). Highly expressed in liver and testis. Expressed at lower level in brain, lungs, and skeletal muscle. The helicase and foldase activities reside in two separate domains, the helicase in the N-terminus and the foldase in the C- terminus. The 3 X 5 AA repeats seem to be critical for the RNA folding activity. Acetylation by CREBBP/CBP inhibits the helicase activity. Deacetylation by SIRT7 promotes the helicase activity and overcomes R- loop-mediated stalling of RNA polymerases. Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. nucleotide binding immune system process positive regulation of myeloid dendritic cell cytokine production nucleic acid binding RNA binding RNA helicase activity double-stranded RNA binding helicase activity protein binding ATP binding nucleus nucleoplasm nucleolus cytoplasm mitochondrion cytosol rRNA processing transcription from RNA polymerase II promoter response to virus hydrolase activity rRNA binding snoRNA binding miRNA binding identical protein binding positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA innate immune response defense response to virus 7SK snRNA binding uc007fhn.1 uc007fhn.2 uc007fhn.3 
ENSMUST00000045870.5 Rnf225 ENSMUST00000045870.5 ring finger protein 225 (from RefSeq NM_029809.2) ENSMUST00000045870.1 ENSMUST00000045870.2 ENSMUST00000045870.3 ENSMUST00000045870.4 NM_029809 Q9D7D1 RN225_MOUSE Rnf225 uc009feq.1 uc009feq.2 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane metal ion binding uc009feq.1 uc009feq.2 
ENSMUST00000045876.8 Firrm ENSMUST00000045876.8 FIGNL1 interacting regulator of recombination and mitosis, transcript variant 1 (from RefSeq NM_201364.2) ENSMUST00000045876.1 ENSMUST00000045876.2 ENSMUST00000045876.3 ENSMUST00000045876.4 ENSMUST00000045876.5 ENSMUST00000045876.6 ENSMUST00000045876.7 FIRRM_MOUSE Firrm NM_201364 Q3TQQ9 Q3UR98 Q5RKU3 Q7TMQ3 uc007dhu.1 uc007dhu.2 uc007dhu.3 uc007dhu.4 Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities. Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis. In complex with FIGL1 may regulate homologous recombination. Interacts (via its N-terminal region) with PLK1; controls PLK1 kinase activity. Interacts (via the KVVXF motif) with PPP1CC; controls PLK1 kinase activity. Interacts with FIGNL1; may regulate homologous recombination. Chromosome, centromere, kinetochore Nucleus Chromosome, centromere Midbody Cytoplasm, cytoskeleton, spindle Note=Exhibits cell-cycle-dependent distribution during mitosis. Detected in the nucleus in interphase. Colocalizes with PLK1 to the centromeres in a nearby prometaphase cells. Relocates to the central spindle in anaphase and to the midbody in telophase cells. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TQQ9-1; Sequence=Displayed; Name=2; IsoId=Q3TQQ9-2; Sequence=VSP_023447; Name=3; IsoId=Q3TQQ9-3; Sequence=VSP_023446; Phosphorylation at Ser-101 by PLK1 strengthens FIRRM-PLK1 interaction. Phosphorylation at Ser-795 by PLK1 negatively regulates its interaction with PPP1CC. molecular_function cellular_component biological_process uc007dhu.1 uc007dhu.2 uc007dhu.3 uc007dhu.4 
ENSMUST00000045884.17 Klhdc4 ENSMUST00000045884.17 kelch domain containing 4 (from RefSeq NM_145605.2) ENSMUST00000045884.1 ENSMUST00000045884.10 ENSMUST00000045884.11 ENSMUST00000045884.12 ENSMUST00000045884.13 ENSMUST00000045884.14 ENSMUST00000045884.15 ENSMUST00000045884.16 ENSMUST00000045884.2 ENSMUST00000045884.3 ENSMUST00000045884.4 ENSMUST00000045884.5 ENSMUST00000045884.6 ENSMUST00000045884.7 ENSMUST00000045884.8 ENSMUST00000045884.9 G3X961 G3X961_MOUSE Klhdc4 NM_145605 uc009nsb.1 uc009nsb.2 uc009nsb.3 uc009nsb.4 uc009nsb.1 uc009nsb.2 uc009nsb.3 uc009nsb.4 
ENSMUST00000045887.9 Cisd1 ENSMUST00000045887.9 CDGSH iron sulfur domain 1 (from RefSeq NM_134007.4) CISD1_MOUSE D10Ertd214e ENSMUST00000045887.1 ENSMUST00000045887.2 ENSMUST00000045887.3 ENSMUST00000045887.4 ENSMUST00000045887.5 ENSMUST00000045887.6 ENSMUST00000045887.7 ENSMUST00000045887.8 NM_134007 Q3V2I3 Q8WUQ5 Q91WS0 Zcd1 uc007foq.1 uc007foq.2 uc007foq.3 L-cysteine transaminase that catalyzes the reversible transfer of the amino group from L-cysteine to the alpha-keto acid 2- oxoglutarate to respectively form 2-oxo-3-sulfanylpropanoate and L- glutamate (By similarity). The catalytic cycle occurs in the presence of pyridoxal 5'-phosphate (PLP) cofactor that facilitates transamination by initially forming an internal aldimine with the epsilon-amino group of active site Lys-55 residue on the enzyme (PLP- enzyme aldimine), subsequently displaced by formation of an external aldimine with the substrate amino group (PLP-L-cysteine aldimine). The external aldimine is further deprotonated to form a carbanion intermediate, which in the presence of 2-oxoglutarate regenerates PLP yielding final products 2-oxo-3-sulfanylpropanoate and L-glutamate. The proton transfer in carbanion intermediate is suggested to be controlled by the active site lysine residue, whereas PLP stabilizes carbanion structure through electron delocalization, also known as the electron sink effect (By similarity). Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (PubMed:17376863). May be involved in iron-sulfur cluster shuttling and/or in redox reactions. Can transfer the [2Fe-2S] cluster to an apo- acceptor protein only when in the oxidation state, likely serving as a redox sensor that regulates mitochondrial iron-sulfur cluster assembly and iron trafficking upon oxidative stress (By similarity). Reaction=2-oxoglutarate + L-cysteine = 2-oxo-3-sulfanylpropanoate + L- glutamate; Xref=Rhea:RHEA:17441, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:35235, ChEBI:CHEBI:57678; EC=2.6.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17442; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17443; Evidence=; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 1 [2Fe-2S] cluster per subunit. The [2Fe-2S] cluster is redox-active and pH labile and is significantly less stable at pH 4.5 as compared with pH 7.0. ; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Homodimer. Mitochondrion outer membrane ; Single-pass type III membrane protein Liver, adipose, skeletal muscle and heart (at protein level). Widely expressed. Expressed at the highest levels in the heart. Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. Belongs to the CISD protein family. iron ion binding mitochondrion mitochondrial outer membrane membrane integral component of membrane cytoplasmic side of mitochondrial outer membrane identical protein binding intracellular membrane-bounded organelle regulation of cellular respiration metal ion binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding uc007foq.1 uc007foq.2 uc007foq.3 
ENSMUST00000045897.15 Ptma ENSMUST00000045897.15 prothymosin alpha, transcript variant 5 (from RefSeq NR_153834.2) ENSMUST00000045897.1 ENSMUST00000045897.10 ENSMUST00000045897.11 ENSMUST00000045897.12 ENSMUST00000045897.13 ENSMUST00000045897.14 ENSMUST00000045897.2 ENSMUST00000045897.3 ENSMUST00000045897.4 ENSMUST00000045897.5 ENSMUST00000045897.6 ENSMUST00000045897.7 ENSMUST00000045897.8 ENSMUST00000045897.9 NR_153834 Ptma Q0VGU2 Q0VGU2_MOUSE uc007bvp.1 uc007bvp.2 uc007bvp.3 Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Interacts with NUPR1; regulates apoptotic process. Belongs to the pro/parathymosin family. nucleus nucleoplasm cytosol activating transcription factor binding negative regulation of apoptotic process uc007bvp.1 uc007bvp.2 uc007bvp.3 
ENSMUST00000045898.4 Pcyt1b ENSMUST00000045898.4 phosphate cytidylyltransferase 1, choline, beta isoform, transcript variant 1 (from RefSeq NM_211138.1) ENSMUST00000045898.1 ENSMUST00000045898.2 ENSMUST00000045898.3 NM_211138 PCY1B_MOUSE Q3UEW0 Q80Y63 Q811Q8 Q811Q9 Q8BKD2 Q8C085 uc009tsw.1 uc009tsw.2 uc009tsw.3 [Isoform 1]: Catalyzes the key rate-limiting step in the CDP- choline pathway for phosphatidylcholine biosynthesis (PubMed:12842190). Plays an important role in ovary maturation and the maintenance of sperm production (PubMed:15143167). [Isoform 2]: Catalyzes the key rate-limiting step in the CDP- choline pathway for phosphatidylcholine biosynthesis. Reaction=CTP + H(+) + phosphocholine = CDP-choline + diphosphate; Xref=Rhea:RHEA:18997, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:58779, ChEBI:CHEBI:295975; EC=2.7.7.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18998; Evidence=; Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2. Homodimer. Endoplasmic reticulum Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CCTbeta2 ; IsoId=Q811Q9-1; Sequence=Displayed; Name=2; Synonyms=CCTbeta3 ; IsoId=Q811Q9-2; Sequence=VSP_020041, VSP_020042; [Isoform 1]: Highly expressed in brain (at protein level) (PubMed:12842190). Expressed in liver (at protein level) (PubMed:12842190). Expressed at lower levels in lung and gonads (PubMed:15143167). [Isoform 2]: Expressed in brain (at protein level) (PubMed:12842190). Expressed at lower levels in lung and gonads (PubMed:15143167). [Isoform 1]: Expression is low at 7 dpc, reaches a maximum at 15 dpc and decreases at 17 dpc. [Isoform 2]: Not expressed in embryo. Expression starts at 5 weeks. Female mice lacking isoform 1 have reduced fecundity due to failure in ovary maturation. Male mice lacking isoform 1 have reduced fecundity due to testicular degeneration. Belongs to the cytidylyltransferase family. Sequence=BAC27658.1; Type=Erroneous initiation; Evidence=; ovarian follicle development catalytic activity choline-phosphate cytidylyltransferase activity endoplasmic reticulum lipid metabolic process phosphatidylcholine biosynthetic process CDP-choline pathway spermatogenesis phospholipid biosynthetic process biosynthetic process transferase activity nucleotidyltransferase activity phosphatidylcholine binding uc009tsw.1 uc009tsw.2 uc009tsw.3 
ENSMUST00000045902.13 Fmo2 ENSMUST00000045902.13 flavin containing monooxygenase 2, transcript variant 3 (from RefSeq NM_018881.4) ENSMUST00000045902.1 ENSMUST00000045902.10 ENSMUST00000045902.11 ENSMUST00000045902.12 ENSMUST00000045902.2 ENSMUST00000045902.3 ENSMUST00000045902.4 ENSMUST00000045902.5 ENSMUST00000045902.6 ENSMUST00000045902.7 ENSMUST00000045902.8 ENSMUST00000045902.9 FMO2_MOUSE Fmo2 NM_018881 Q8K2I3 Q9QZF7 uc007dhb.1 uc007dhb.2 uc007dhb.3 Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation (PubMed:18930751). Catalyzes the S-oxygenation of the prodrug ethionamide (ETA) to the S-oxide (ETASO), the first step in its bioactivation following by the second oxygenation to the sulfinic acid but to a lesser extend (PubMed:18930751). Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Kinetic parameters: KM=2131 uM for ethionamide ; pH dependence: Optimum pH is 10.5.; Microsome membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Belongs to the FMO family. monooxygenase activity N,N-dimethylaniline monooxygenase activity endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process NADP metabolic process xenobiotic metabolic process toxin metabolic process membrane integral component of membrane oxidoreductase activity drug metabolic process organelle membrane intracellular membrane-bounded organelle flavin adenine dinucleotide binding NADP binding oxidation-reduction process NADPH oxidation oxygen metabolic process uc007dhb.1 uc007dhb.2 uc007dhb.3 
ENSMUST00000045903.8 Trak1 ENSMUST00000045903.8 trafficking protein, kinesin binding 1, transcript variant 1 (from RefSeq NM_175114.4) ENSMUST00000045903.1 ENSMUST00000045903.2 ENSMUST00000045903.3 ENSMUST00000045903.4 ENSMUST00000045903.5 ENSMUST00000045903.6 ENSMUST00000045903.7 NM_175114 Q6PD31 Q8BYA3 TRAK1_MOUSE uc009sdf.1 uc009sdf.2 uc009sdf.3 uc009sdf.4 Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (By similarity). Involved in mitochondrial motility (PubMed:24995978). When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (By similarity). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain- independent, anterograde transport of mitochondria (By similarity). Interacts with RHOT1 and RHOT2. Found in a complex with KIF5B, OGT, RHOT1 and RHOT2. Interacts with HGS (By similarity). Interacts with GABRA1 (PubMed:16380713). Interacts with KIF5C. Interacts with OGT; stable interaction is not required for glycosylation of this protein by OGT. Isoform 1 interacts with OGT (By similarity). Cytoplasm Nucleus Mitochondrion Early endosome Endosome Mitochondrion membrane Cytoplasm, cell cortex Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HGS/HRS. Colocalizes with MGARP at the mitochondria. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PD31-1; Sequence=Displayed; Name=2; IsoId=Q6PD31-2; Sequence=VSP_039277, VSP_039278, VSP_039279; Widely expressed with the greatest expression in brain, liver and kidney. Detected throughout the CNS, including the cortex, hippocamps, thalamus and various subcortical nuclei of the forebrain and midbrain, the granule of Purkinje layers of the cerebellum and the gray matter of the spinal cord. High level detected in lower moter neurons (at protein level). O-glycosylated (PubMed:24995978). Glycosylated by OGT; glycosylation in response to increased extracellular glucose levels is required for and leads to regulation of mitochondrial motility by OGT (By similarity). Note=A spontaneous mutation (hyrt mice) causes a recessively transmitted form of hypertonia neurological dysfunction characterized by postural abnormalities, jerky movements and tremormutant. Hyrt mice have much lower levels of GABA(A) receptors in the CNS, particularly the lower motor neurons, than do wild-type mice, indicating that the hypertonicity of the mutants is likely to be caused by deficits in GABA-mediated motor neuron inhibition. Belongs to the milton family. receptor binding nucleus cytoplasm mitochondrion endosome early endosome cell cortex protein targeting anterograde axonal transport protein localization endosome to lysosome transport membrane myosin binding axonal transport of mitochondrion neurogenesis dendrite TPR domain binding cytoplasmic vesicle mitochondrial membrane axonal growth cone vesicle transport along microtubule mitochondrion distribution perinuclear region of cytoplasm dendrite morphogenesis positive regulation of axonogenesis GABA receptor binding anterograde axonal transport of mitochondrion axon cytoplasm uc009sdf.1 uc009sdf.2 uc009sdf.3 uc009sdf.4 
ENSMUST00000045905.15 Fermt2 ENSMUST00000045905.15 fermitin family member 2, transcript variant 3 (from RefSeq NM_146054.4) ENSMUST00000045905.1 ENSMUST00000045905.10 ENSMUST00000045905.11 ENSMUST00000045905.12 ENSMUST00000045905.13 ENSMUST00000045905.14 ENSMUST00000045905.2 ENSMUST00000045905.3 ENSMUST00000045905.4 ENSMUST00000045905.5 ENSMUST00000045905.6 ENSMUST00000045905.7 ENSMUST00000045905.8 ENSMUST00000045905.9 FERM2_MOUSE NM_146054 Plekhc1 Q8C542 Q8CIB5 Q8K035 uc007tgq.1 uc007tgq.2 uc007tgq.3 Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. Interacts with ITGB1; the interaction is inhibited in presence of ITGB1BP1. Interacts with FBLIM1. Interacts with active, unphosphorylated CTNNB1. Identified in a complex with CTNNB1 and TCF7L2/TCF4 (By similarity). Interacts with ILK, ITGB1 and ITGB3. Cytoplasm Cytoplasm, cell cortex Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, stress fiber Cell junction, focal adhesion Membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus Cytoplasm, myofibril, sarcomere, I band. Cell surface. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides (By similarity). Detected in adult heart muscle (at protein level). Detected in heart, skeletal muscle and testis. The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. The PH domain binds phospholipids. Binds preferentially phosphatidylinositol-3,4,5-trisphosphate, and has lower affinity for phosphatidylinositol-4,5-bisphosphate (By similarity). The N-terminal region displays a ubiquitin-type fold and mediates interaction with membranes containing negatively charged phosphatidylinositol phosphate via a surface enriched in positively charged residues. Complete embryonic lethality at peri-implantation stage, due to severe detachment of the endoderm and epiblast from the basement membrane. Heterozygous mice lacking one copy of Fermt2 show no visible phenotype, but show decreased tumor angiogenesis upon transplantation of tumor cells, and their blood vessels are abnormally leaky. Belongs to the kindlin family. Sequence=AAH34168.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; phosphatidylinositol-3,4,5-trisphosphate binding nucleus nucleoplasm cytoplasm cytoskeleton plasma membrane focal adhesion cell cortex cell adhesion cell-matrix adhesion transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway lipid binding regulation of cell shape cell surface membrane Wnt signaling pathway cell junction extrinsic component of cytoplasmic side of plasma membrane lamellipodium membrane I band integrin activation substrate adhesion-dependent cell spreading cell projection focal adhesion assembly actin filament binding protein localization to membrane stress fiber uc007tgq.1 uc007tgq.2 uc007tgq.3 
ENSMUST00000045912.3 Rptn ENSMUST00000045912.3 repetin (from RefSeq NM_009100.2) ENSMUST00000045912.1 ENSMUST00000045912.2 G3X968 NM_009100 P97347 RPTN_MOUSE uc008qfh.1 uc008qfh.2 Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Secreted, extracellular space, extracellular matrix Detectable in the stratified internal epithelia of forestomach and tongue and to a lesser degree in normal skin epidermis, where it is restricted to the differentiated suprabasal cell layers. Overexpressed in skin tumors. Expressed during late differentiation of the epidermis. Can be divided into a N-terminal domain with significant homology to S100-like calcium-binding proteins, a central domain containing a series of short tandem repeats, and two flanking segments with low homology to the consensus sequences of the central repeats. Potential substrate of transglutaminase. Some arginines are probably converted to citrullines by peptidylarginine deimidase. Belongs to the S100-fused protein family. cornified envelope calcium ion binding extracellular region metal ion binding transition metal ion binding uc008qfh.1 uc008qfh.2 
ENSMUST00000045918.15 Alg3 ENSMUST00000045918.15 ALG3 alpha-1,3- mannosyltransferase, transcript variant 1 (from RefSeq NM_145939.3) ALG3_MOUSE E9QKP9 ENSMUST00000045918.1 ENSMUST00000045918.10 ENSMUST00000045918.11 ENSMUST00000045918.12 ENSMUST00000045918.13 ENSMUST00000045918.14 ENSMUST00000045918.2 ENSMUST00000045918.3 ENSMUST00000045918.4 ENSMUST00000045918.5 ENSMUST00000045918.6 ENSMUST00000045918.7 ENSMUST00000045918.8 ENSMUST00000045918.9 NM_145939 Not Not56l Q8K2A8 uc007yqe.1 uc007yqe.2 uc007yqe.3 uc007yqe.4 Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol. Reaction=a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)- alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D- Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+); Xref=Rhea:RHEA:29527, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:12627, Rhea:RHEA-COMP:12628, ChEBI:CHEBI:15378, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:132515, ChEBI:CHEBI:132516; EC=2.4.1.258; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the glycosyltransferase 58 family. mannosyltransferase activity alpha-1,3-mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups integral component of endoplasmic reticulum membrane dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity mannosylation uc007yqe.1 uc007yqe.2 uc007yqe.3 uc007yqe.4 
ENSMUST00000045921.14 Mfsd2b ENSMUST00000045921.14 MFSD2 lysolipid transporter B, sphingolipid (from RefSeq NM_001033488.2) B8JK43 B8JK43_MOUSE ENSMUST00000045921.1 ENSMUST00000045921.10 ENSMUST00000045921.11 ENSMUST00000045921.12 ENSMUST00000045921.13 ENSMUST00000045921.2 ENSMUST00000045921.3 ENSMUST00000045921.4 ENSMUST00000045921.5 ENSMUST00000045921.6 ENSMUST00000045921.7 ENSMUST00000045921.8 ENSMUST00000045921.9 Mfsd2b NM_001033488 uc007myq.1 uc007myq.2 uc007myq.3 uc007myq.4 Belongs to the major facilitator superfamily. integral component of plasma membrane lipid transport carbohydrate transport symporter activity membrane integral component of membrane sphingolipid transporter activity transmembrane transport uc007myq.1 uc007myq.2 uc007myq.3 uc007myq.4 
ENSMUST00000045923.10 Limd2 ENSMUST00000045923.10 LIM domain containing 2, transcript variant 2 (from RefSeq NM_172397.4) ENSMUST00000045923.1 ENSMUST00000045923.2 ENSMUST00000045923.3 ENSMUST00000045923.4 ENSMUST00000045923.5 ENSMUST00000045923.6 ENSMUST00000045923.7 ENSMUST00000045923.8 ENSMUST00000045923.9 LIMD2_MOUSE Limd2 NM_172397 Q8BGB5 uc007lyd.1 uc007lyd.2 Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. Interacts with ILK. Cytoplasm Nucleus Note=Mainly found in cytoplasm, concentrated in membrane ruffles and in streaks reminiscent of focal adhesion plaques. Also found in nucleus. molecular_function cellular_component nucleus cytoplasm biological_process metal ion binding uc007lyd.1 uc007lyd.2 
ENSMUST00000045931.12 Zfp410 ENSMUST00000045931.12 zinc finger protein 410, transcript variant 8 (from RefSeq NR_157103.1) Apa1 D12Ertd748e ENSMUST00000045931.1 ENSMUST00000045931.10 ENSMUST00000045931.11 ENSMUST00000045931.2 ENSMUST00000045931.3 ENSMUST00000045931.4 ENSMUST00000045931.5 ENSMUST00000045931.6 ENSMUST00000045931.7 ENSMUST00000045931.8 ENSMUST00000045931.9 NR_157103 Q8BKX7 Q8BWB3 Q8BZZ7 Q8R5L2 Q8VDL2 ZN410_MOUSE Zfp410 Znf410 uc007oex.1 uc007oex.2 uc007oex.3 uc007oex.4 Transcription factor that binds to the sequence motif 5'- CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416). Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416). May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (By similarity). May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (By similarity). However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (By similarity). Interacts with CDKN2A/p14ARF. Nucleus Chromosome Note=Directly binds to the sequence motif 5'-CATCCCATAATA-3'. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BKX7-1; Sequence=Displayed; Name=2; IsoId=Q8BKX7-2; Sequence=VSP_008490, VSP_008491; Name=3; IsoId=Q8BKX7-3; Sequence=VSP_008492, VSP_008493; The five zinc finger domains are necessary and sufficient to bind to DNA. O-glycosylated. O-GlcNAcylation may occur in response to increasing glucose levels and affect transcription factor activity. Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation. Mice are viable and healthy, but display reduced expression of Chd4, leading to rerepression of fetal hemoglobin genes Hbg1 and Hbg2. nucleic acid binding DNA binding nucleus biological_process metal ion binding uc007oex.1 uc007oex.2 uc007oex.3 uc007oex.4 
ENSMUST00000045942.9 Emx1 ENSMUST00000045942.9 empty spiracles homeobox 1 (from RefSeq NM_010131.2) EMX1_MOUSE ENSMUST00000045942.1 ENSMUST00000045942.2 ENSMUST00000045942.3 ENSMUST00000045942.4 ENSMUST00000045942.5 ENSMUST00000045942.6 ENSMUST00000045942.7 ENSMUST00000045942.8 Emx-1 NM_010131 Q04742 Q3SXG0 uc009cpi.1 uc009cpi.2 uc009cpi.3 Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. Interacts with WRD11 (via the N-terminal and the central portion of the protein); the interaction associates EMX1 with GLI3. Nucleus Cerebral cortex. Expressed in the olfactory bulbs. Detectable from 9.5 dpc. Belongs to the EMX homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development DNA binding protein binding nucleus nucleolus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development central nervous system development brain development post-embryonic development telencephalon development cerebral cortex regionalization cerebral cortex neuron differentiation cerebral cortex development neuron differentiation response to drug sequence-specific DNA binding brain morphogenesis homeostasis of number of cells radial glial cell differentiation neuroepithelial cell differentiation regulation of oligodendrocyte progenitor proliferation neuron projection extension uc009cpi.1 uc009cpi.2 uc009cpi.3 
ENSMUST00000045959.8 Bpifb5 ENSMUST00000045959.8 BPI fold containing family B, member 5 (from RefSeq NM_144890.2) BC018465 Bpifb5 ENSMUST00000045959.1 ENSMUST00000045959.2 ENSMUST00000045959.3 ENSMUST00000045959.4 ENSMUST00000045959.5 ENSMUST00000045959.6 ENSMUST00000045959.7 NM_144890 Q3UQ05 Q3UQ05_MOUSE uc008niy.1 uc008niy.2 uc008niy.3 molecular_function cellular_component biological_process lipid binding uc008niy.1 uc008niy.2 uc008niy.3 
ENSMUST00000045970.8 Gpc1 ENSMUST00000045970.8 glypican 1 (from RefSeq NM_016696.5) ENSMUST00000045970.1 ENSMUST00000045970.2 ENSMUST00000045970.3 ENSMUST00000045970.4 ENSMUST00000045970.5 ENSMUST00000045970.6 ENSMUST00000045970.7 GPC1_MOUSE NM_016696 Q9QZF2 uc007cbs.1 uc007cbs.2 uc007cbs.3 Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Binds Cu(2+) or Zn(2+) ions. Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Note=S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP amyloid-beta peptides in lipid rafts in Alzheimer disease brains. [Secreted glypican-1]: Secreted, extracellular space. S-nitrosylated in a Cu(2+)-dependent manner. Nitric acid (NO) is released from the nitrosylated cysteines by ascorbate or by some other reducing agent, in a Cu(2+) or Zn(2+) dependent manner. This free nitric oxide is then capable of cleaving the heparan sulfate side chains. N- and O-glycosylated. N-glycosylation is mainly of the complex type containing sialic acid. O-glycosylated with heparan sulfate. The heparan sulfate chains can be cleaved either by the action of heparanase or, degraded by a deaminative process that uses nitric oxide (NO) released from the S-nitrosylated cysteines. This process is triggered by ascorbate, or by some other reducing agent, in a Cu(2+)- or Zn(2+) dependent manner. Cu(2+) ions are provided by ceruloproteins such as APP, PRNP or CP which associate with GCP1 in intracellular compartments or lipid rafts. This cell-associated glypican is further processed to give rise to a medium-released species. Null mice with induced pancreatic ductal adenocarcinomas (PDACs) exhibit attenuated pancreatic tumor growth and invasiveness, decreased cancer cell proliferation and mitogen-activated protein kinase activation. Pancreatic cancer cells isolated from the tumors of GPC1 (-/-) mice were not as invasive in response to fibroblast growth factor-2 (FGF-2) as cancer cells isolated from wild- type mice. Belongs to the glypican family. copper ion binding extracellular region extracellular space nucleoplasm endosome Golgi lumen cytosol plasma membrane regulation of signal transduction cell surface Schwann cell differentiation membrane cell migration fibroblast growth factor binding heparan sulfate proteoglycan catabolic process extracellular matrix anchored component of membrane myelin assembly negative regulation of fibroblast growth factor receptor signaling pathway neuronal cell body laminin binding membrane raft synapse anchored component of plasma membrane collagen V binding regulation of protein localization to membrane positive regulation of skeletal muscle cell differentiation uc007cbs.1 uc007cbs.2 uc007cbs.3 
ENSMUST00000045971.9 Chrnb1 ENSMUST00000045971.9 cholinergic receptor nicotinic beta 1 subunit, transcript variant 4 (from RefSeq NR_184437.1) ACHB_MOUSE Acrb ENSMUST00000045971.1 ENSMUST00000045971.2 ENSMUST00000045971.3 ENSMUST00000045971.4 ENSMUST00000045971.5 ENSMUST00000045971.6 ENSMUST00000045971.7 ENSMUST00000045971.8 NR_184437 P09690 Q5F292 uc007jrq.1 uc007jrq.2 uc007jrq.3 uc007jrq.4 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII. Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub- subfamily. postsynaptic membrane organization skeletal muscle contraction transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity protein binding plasma membrane integral component of plasma membrane acetylcholine-gated channel complex ion transport cation transport muscle contraction signal transduction chemical synaptic transmission synaptic transmission, cholinergic neuromuscular synaptic transmission channel activity ligand-gated ion channel activity acetylcholine receptor activity membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction neuromuscular junction ion transmembrane transport response to nicotine behavioral response to nicotine acetylcholine binding regulation of membrane potential neuron projection synapse postsynaptic membrane muscle fiber development neurological system process regulation of postsynaptic membrane potential excitatory postsynaptic potential integral component of postsynaptic specialization membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc007jrq.1 uc007jrq.2 uc007jrq.3 uc007jrq.4 
ENSMUST00000045976.7 Timm8a2 ENSMUST00000045976.7 translocase of inner mitochondrial membrane 8A2 (from RefSeq NM_001037744.1) ENSMUST00000045976.1 ENSMUST00000045976.2 ENSMUST00000045976.3 ENSMUST00000045976.4 ENSMUST00000045976.5 ENSMUST00000045976.6 NM_001037744 Q4FZG7 TI8AB_MOUSE Timm8ab uc007var.1 uc007var.2 uc007var.3 Putative mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). Heterohexamer; possibly composed of 3 copies of TIMM8AB and 3 copies of TIMM13. Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of Timm8ab from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). Belongs to the small Tim family. molecular_function mitochondrion mitochondrial inner membrane mitochondrial intermembrane space protein transport membrane metal ion binding chaperone-mediated protein transport uc007var.1 uc007var.2 uc007var.3 
ENSMUST00000045986.8 Spr ENSMUST00000045986.8 sepiapterin reductase (from RefSeq NM_011467.2) ENSMUST00000045986.1 ENSMUST00000045986.2 ENSMUST00000045986.3 ENSMUST00000045986.4 ENSMUST00000045986.5 ENSMUST00000045986.6 ENSMUST00000045986.7 NM_011467 Q91XH5 Q91XH5_MOUSE Spr uc291gju.1 uc291gju.2 Cytoplasm Belongs to the sepiapterin reductase family. sepiapterin reductase activity nucleoplasm cytosol tetrahydrobiopterin biosynthetic process nitric oxide biosynthetic process oxidation-reduction process uc291gju.1 uc291gju.2 
ENSMUST00000045993.15 Cops4 ENSMUST00000045993.15 COP9 signalosome subunit 4, transcript variant 1 (from RefSeq NM_012001.3) Cops4 ENSMUST00000045993.1 ENSMUST00000045993.10 ENSMUST00000045993.11 ENSMUST00000045993.12 ENSMUST00000045993.13 ENSMUST00000045993.14 ENSMUST00000045993.2 ENSMUST00000045993.3 ENSMUST00000045993.4 ENSMUST00000045993.5 ENSMUST00000045993.6 ENSMUST00000045993.7 ENSMUST00000045993.8 ENSMUST00000045993.9 NM_012001 Q14AI7 Q14AI7_MOUSE uc008yhs.1 uc008yhs.2 uc008yhs.3 uc008yhs.4 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Nucleus Vesicle Belongs to the CSN4 family. cytoplasm synaptic vesicle COP9 signalosome uc008yhs.1 uc008yhs.2 uc008yhs.3 uc008yhs.4 
ENSMUST00000045994.8 Rbm34 ENSMUST00000045994.8 RNA binding motif protein 34, transcript variant 1 (from RefSeq NM_172762.3) B2RUP0 D8Ertd233e ENSMUST00000045994.1 ENSMUST00000045994.2 ENSMUST00000045994.3 ENSMUST00000045994.4 ENSMUST00000045994.5 ENSMUST00000045994.6 ENSMUST00000045994.7 NM_172762 Q8C5L7 RBM34_MOUSE uc009nzb.1 uc009nzb.2 uc009nzb.3 uc009nzb.4 Nucleus, nucleolus Belongs to the RRM RBM34 family. Sequence=BAC37124.1; Type=Frameshift; Evidence=; nucleic acid binding RNA binding nucleus nucleolus biological_process uc009nzb.1 uc009nzb.2 uc009nzb.3 uc009nzb.4 
ENSMUST00000046001.7 Avp ENSMUST00000046001.7 arginine vasopressin (from RefSeq NM_009732.2) Avp ENSMUST00000046001.1 ENSMUST00000046001.2 ENSMUST00000046001.3 ENSMUST00000046001.4 ENSMUST00000046001.5 ENSMUST00000046001.6 NM_009732 Q3UUQ5 Q3UUQ5_MOUSE uc008mjh.1 uc008mjh.2 uc008mjh.3 uc008mjh.4 This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin binds to vasopressin receptors and functions as a vasopressor, to constrict blood vessels and increase blood pressure, and as an antidiuretic, to reduce the production of urine. Neurophysin 2 functions as a carrier protein in the transport of arginine vasopressin. This gene is present in a gene cluster with the related gene oxytocin on chromosome 2. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CJ057117.1, BU558351.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Belongs to the vasopressin/oxytocin family. maternal aggressive behavior positive regulation of systemic arterial blood pressure protein kinase activity neuropeptide hormone activity neurohypophyseal hormone activity extracellular region extracellular space apoptotic process signal transduction positive regulation of cytosolic calcium ion concentration negative regulation of female receptivity grooming behavior locomotory behavior positive regulation of cell proliferation positive regulation of gene expression positive regulation of glutamate secretion response to organic cyclic compound secretory granule positive regulation of cell growth dendrite positive regulation of prostaglandin biosynthetic process V1A vasopressin receptor binding V1B vasopressin receptor binding positive regulation of cellular pH reduction positive regulation of peptidyl-serine phosphorylation response to testosterone response to nicotine social behavior regulation of renal sodium excretion hyperosmotic salinity response maternal behavior cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process penile erection negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to ethanol positive regulation of vasoconstriction multicellular organismal water homeostasis negative regulation of transmission of nerve impulse ERK1 and ERK2 cascade protein kinase C signaling negative regulation of release of cytochrome c from mitochondria uc008mjh.1 uc008mjh.2 uc008mjh.3 uc008mjh.4 
ENSMUST00000046004.6 Tex44 ENSMUST00000046004.6 testis expressed 44 (from RefSeq NM_027966.1) A6H651 ENSMUST00000046004.1 ENSMUST00000046004.2 ENSMUST00000046004.3 ENSMUST00000046004.4 ENSMUST00000046004.5 NM_027966 Q497K4 Q9DA60 TEX44_MOUSE uc007bvo.1 uc007bvo.2 uc007bvo.3 uc007bvo.4 Cytoplasm Sequence=AAI00498.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cytoplasm biological_process uc007bvo.1 uc007bvo.2 uc007bvo.3 uc007bvo.4 
ENSMUST00000046005.9 Glis1 ENSMUST00000046005.9 GLIS family zinc finger 1 (from RefSeq NM_147221.2) ENSMUST00000046005.1 ENSMUST00000046005.2 ENSMUST00000046005.3 ENSMUST00000046005.4 ENSMUST00000046005.5 ENSMUST00000046005.6 ENSMUST00000046005.7 ENSMUST00000046005.8 GLIS1_MOUSE Gli5 Glis1 NM_147221 Q6NZF6 Q8K1M4 Q8R4Z3 uc008tzv.1 uc008tzv.2 uc008tzv.3 Acts both as a repressor and an ctivator of transcription (PubMed:12042312, PubMed:12385751, PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (PubMed:12042312). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807, PubMed:30544251). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (PubMed:30544251). Interacts with KLF4. Interacts with POU5F1 and/or POU5F1B. Interacts with SOX2. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8K1M4-1; Sequence=Displayed; Name=2 ; IsoId=Q8K1M4-2; Sequence=VSP_051623; In the adult, expressed highly in placenta and kidney and at lower levels in the testis, brain, colon, brown fat tissue and thymus. During embryo development, expressed in the frontal nasal region, branchial arches, somites, vibrissal and hair follicles, limb buds, craniofacial regions, ventral part of the tail, intervertebral disks, teeth, eyes and kidney. Higher expression is detected in unfertilized eggs and one-cell embryos compared to two-cells embryos and adult tissues (PubMed:21654807). In the embryo, expression is detected at 10 dpc becoming stronger by 11 dpc and continuing through to 16.5 dpc. No visible phenotype. The combined transgenic expression of the OSK transcription factors POU5F1/OCT4, SOX2 and KLF4, reprograms differentiated cells into induced pluripotent stem cells/iSPCs. iPSCs exhibit the morphology and properties of embryonic stem/ES cells. The coexpression of GLIS1 can increase the efficiency of OSK-induced pluripotent stem cells/iPSCs production. Belongs to the GLI C2H2-type zinc-finger protein family. Sequence=AAH66157.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding osteoblast differentiation nucleic acid binding DNA binding nucleus regulation of transcription from RNA polymerase II promoter negative regulation of cell fate commitment cell differentiation fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding uc008tzv.1 uc008tzv.2 uc008tzv.3 
ENSMUST00000046011.12 Nol10 ENSMUST00000046011.12 nucleolar protein 10 (from RefSeq NM_001008421.1) ENSMUST00000046011.1 ENSMUST00000046011.10 ENSMUST00000046011.11 ENSMUST00000046011.2 ENSMUST00000046011.3 ENSMUST00000046011.4 ENSMUST00000046011.5 ENSMUST00000046011.6 ENSMUST00000046011.7 ENSMUST00000046011.8 ENSMUST00000046011.9 Gm67 NM_001008421 NOL10_MOUSE Q5RJG1 uc007ncu.1 uc007ncu.2 uc007ncu.3 Nucleus, nucleolus Belongs to the WD repeat NOL10/ENP2 family. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleus nucleolus small-subunit processome uc007ncu.1 uc007ncu.2 uc007ncu.3 
ENSMUST00000046022.16 Skic2 ENSMUST00000046022.16 SKI2 subunit of superkiller complex (from RefSeq NM_021337.2) ENSMUST00000046022.1 ENSMUST00000046022.10 ENSMUST00000046022.11 ENSMUST00000046022.12 ENSMUST00000046022.13 ENSMUST00000046022.14 ENSMUST00000046022.15 ENSMUST00000046022.2 ENSMUST00000046022.3 ENSMUST00000046022.4 ENSMUST00000046022.5 ENSMUST00000046022.6 ENSMUST00000046022.7 ENSMUST00000046022.8 ENSMUST00000046022.9 NM_021337 Q3TW36 Q6NZR5 SKI2_MOUSE Skic2 uc008cds.1 uc008cds.2 uc008cds.3 Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Component of the SKI complex which consists of SKIC2, SKIC3 and SKIC8. Interacts with HBS1L isoform 2. Nucleus Cytoplasm Belongs to the helicase family. SKI2 subfamily. nucleic acid binding RNA binding RNA helicase activity ATP binding RNA catabolic process Ski complex nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay uc008cds.1 uc008cds.2 uc008cds.3 
ENSMUST00000046028.12 Strip2 ENSMUST00000046028.12 striatin interacting protein 2, transcript variant 3 (from RefSeq NR_104576.1) ENSMUST00000046028.1 ENSMUST00000046028.10 ENSMUST00000046028.11 ENSMUST00000046028.2 ENSMUST00000046028.3 ENSMUST00000046028.4 ENSMUST00000046028.5 ENSMUST00000046028.6 ENSMUST00000046028.7 ENSMUST00000046028.8 ENSMUST00000046028.9 Fam40b Kiaa1170 NR_104576 Q3TQB7 Q80TI6 Q8C7A2 Q8C9H6 STRP2_MOUSE Stripb uc009ben.1 uc009ben.2 uc009ben.3 Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). Component of striatin-interacting phosphatase and kinase (STRIPAK) complex. Interacts with CTTNBP2NL (By similarity). Cytoplasm Note=Enriched in lamellipodia. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C9H6-1; Sequence=Displayed; Name=2; IsoId=Q8C9H6-4; Sequence=VSP_019001, VSP_019002; Name=3; IsoId=Q8C9H6-3; Sequence=VSP_014870; Belongs to the STRIP family. molecular_function cytoplasm cytosol cytoskeleton organization regulation of cell shape cell migration uc009ben.1 uc009ben.2 uc009ben.3 
ENSMUST00000046030.8 Esf1 ENSMUST00000046030.8 ESF1 nucleolar pre-rRNA processing protein homolog (from RefSeq NM_001081090.1) Abtap ENSMUST00000046030.1 ENSMUST00000046030.2 ENSMUST00000046030.3 ENSMUST00000046030.4 ENSMUST00000046030.5 ENSMUST00000046030.6 ENSMUST00000046030.7 ESF1_MOUSE NM_001081090 Q3V1V3 uc008mpn.1 uc008mpn.2 uc008mpn.3 May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). Interacts with ABT1. Forms a complex with ABT1 and suppresses the ABT1-induced activation of polymerase II-directed transcription in mammalian cells (By similarity). Nucleus, nucleolus Nucleus, nucleoplasm Belongs to the ESF1 family. RNA binding nucleus nucleoplasm nucleolus rRNA processing uc008mpn.1 uc008mpn.2 uc008mpn.3 
ENSMUST00000046038.9 Slc25a28 ENSMUST00000046038.9 solute carrier family 25, member 28, transcript variant 1 (from RefSeq NM_145156.1) ENSMUST00000046038.1 ENSMUST00000046038.2 ENSMUST00000046038.3 ENSMUST00000046038.4 ENSMUST00000046038.5 ENSMUST00000046038.6 ENSMUST00000046038.7 ENSMUST00000046038.8 MFRN2_MOUSE Mfrn2 NM_145156 Q8K4J8 Q8K4J9 Q8R0Z5 Q8R578 uc008hon.1 uc008hon.2 uc008hon.3 uc008hon.4 uc008hon.5 Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. Reaction=Fe(2+)(in) = Fe(2+)(out); Xref=Rhea:RHEA:28486, ChEBI:CHEBI:29033; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R0Z5-1; Sequence=Displayed; Name=2; IsoId=Q8R0Z5-2; Sequence=VSP_018416; Ubiquitously expressed at low level. Expression does not vary during erythroid maturation. Belongs to the mitochondrial carrier (TC 2.A.29) family. iron ion transmembrane transporter activity mitochondrion mitochondrial inner membrane ion transport membrane integral component of membrane mitochondrial iron ion transport iron ion homeostasis uc008hon.1 uc008hon.2 uc008hon.3 uc008hon.4 uc008hon.5 
ENSMUST00000046045.13 Nexn ENSMUST00000046045.13 nexilin, transcript variant 2 (from RefSeq NM_199465.4) E9QJX5 ENSMUST00000046045.1 ENSMUST00000046045.10 ENSMUST00000046045.11 ENSMUST00000046045.12 ENSMUST00000046045.2 ENSMUST00000046045.3 ENSMUST00000046045.4 ENSMUST00000046045.5 ENSMUST00000046045.6 ENSMUST00000046045.7 ENSMUST00000046045.8 ENSMUST00000046045.9 NEXN_MOUSE NM_199465 Nexn Q3TQP3 Q3UWU2 Q3UWU6 Q3UX39 Q7TPW1 uc008rtb.1 uc008rtb.2 uc008rtb.3 uc008rtb.4 uc008rtb.5 Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. Interacts with F-actin. Cytoplasm, cytoskeleton Cell junction, adherens junction toplasm, myofibril, sarcomere, Z line Note=Localizes to the cell-matrix AJ. Not found at the cell-cell AJ. actin binding cytoplasm cytoskeleton plasma membrane adherens junction cell-substrate adherens junction homophilic cell adhesion via plasma membrane adhesion molecules axon guidance structural constituent of muscle response to bacterium Z disc cell junction regulation of cell migration axon actin filament binding regulation of cytoskeleton organization dendrite self-avoidance protein binding involved in cell-cell adhesion uc008rtb.1 uc008rtb.2 uc008rtb.3 uc008rtb.4 uc008rtb.5 
ENSMUST00000046049.14 Fmo1 ENSMUST00000046049.14 flavin containing monooxygenase 1, transcript variant 1 (from RefSeq NM_010231.4) ENSMUST00000046049.1 ENSMUST00000046049.10 ENSMUST00000046049.11 ENSMUST00000046049.12 ENSMUST00000046049.13 ENSMUST00000046049.2 ENSMUST00000046049.3 ENSMUST00000046049.4 ENSMUST00000046049.5 ENSMUST00000046049.6 ENSMUST00000046049.7 ENSMUST00000046049.8 ENSMUST00000046049.9 FMO1_MOUSE Fmo-1 Fmo1 NM_010231 P50285 uc007dgx.1 uc007dgx.2 uc007dgx.3 Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (PubMed:9580872, PubMed:32156684). Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (PubMed:32156684). In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (By similarity). Reaction=H(+) + hypotaurine + NADPH + O2 = H2O + NADP(+) + taurine; Xref=Rhea:RHEA:69819, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:57853, ChEBI:CHEBI:58349, ChEBI:CHEBI:507393; EC=1.14.13.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69820; Evidence=; Reaction=H(+) + hypotaurine + NADH + O2 = H2O + NAD(+) + taurine; Xref=Rhea:RHEA:74111, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57540, ChEBI:CHEBI:57853, ChEBI:CHEBI:57945, ChEBI:CHEBI:507393; EC=1.14.13.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74112; Evidence=; Reaction=NADPH + O2 + trimethylamine = H2O + NADP(+) + trimethylamine N-oxide; Xref=Rhea:RHEA:31979, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:15724, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58389; EC=1.14.13.148; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31980; Evidence=; Reaction=H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N- dimethylaniline N-oxide + NADP(+); Xref=Rhea:RHEA:24468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16269, ChEBI:CHEBI:17735, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24469; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Endoplasmic reticulum membrane ; Single-pass membrane protein Liver. Belongs to the FMO family. monooxygenase activity N,N-dimethylaniline monooxygenase activity endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process response to osmotic stress toxin metabolic process membrane integral component of membrane oxidoreductase activity drug metabolic process organelle membrane response to lipopolysaccharide intracellular membrane-bounded organelle flavin adenine dinucleotide binding NADP binding oxidation-reduction process NADPH oxidation uc007dgx.1 uc007dgx.2 uc007dgx.3 
ENSMUST00000046071.5 Klhdc8a ENSMUST00000046071.5 kelch domain containing 8A, transcript variant 3 (from RefSeq NR_184552.1) ENSMUST00000046071.1 ENSMUST00000046071.2 ENSMUST00000046071.3 ENSMUST00000046071.4 KLD8A_MOUSE NR_184552 Q91XA8 uc007con.1 uc007con.2 uc007con.1 uc007con.2 
ENSMUST00000046073.16 Kdm2b ENSMUST00000046073.16 lysine (K)-specific demethylase 2B, transcript variant 1 (from RefSeq NM_001003953.2) ENSMUST00000046073.1 ENSMUST00000046073.10 ENSMUST00000046073.11 ENSMUST00000046073.12 ENSMUST00000046073.13 ENSMUST00000046073.14 ENSMUST00000046073.15 ENSMUST00000046073.2 ENSMUST00000046073.3 ENSMUST00000046073.4 ENSMUST00000046073.5 ENSMUST00000046073.6 ENSMUST00000046073.7 ENSMUST00000046073.8 ENSMUST00000046073.9 Fbl10 Fbxl10 Jhdm1b KDM2B_MOUSE Kiaa3014 NM_001003953 Q3V396 Q6P1G2 Q6PFD0 Q6ZPE8 Q9CSF7 Q9QZN6 uc008zms.1 uc008zms.2 uc008zms.3 uc008zms.4 uc008zms.5 uc008zms.6 The protein encoded by this gene is a H3K36-specific histone demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri- methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (By similarity). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Reaction=2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:42032, Rhea:RHEA-COMP:9785, Rhea:RHEA- COMP:9787, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61976; EC=1.14.11.27; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Histone demethylase activity is inhibited by fumarate. Interacts with SKP1, forming heterodimers (By similarity). The KDM2B-SKP1 heterodimeric complex interacts with the PCGF1-BCORL heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1) (By similarity). Directly interacts with CUL1. The SKP1-KDM2B interacts with UBB (By similarity). Q6P1G2; Q9CQJ4: Rnf2; NbExp=4; IntAct=EBI-1216214, EBI-927321; Nucleus, nucleolus Nucleus Chromosome Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6P1G2-1; Sequence=Displayed; Name=2; IsoId=Q6P1G2-2; Sequence=VSP_011342, VSP_011343; Name=3; IsoId=Q6P1G2-3; Sequence=VSP_017477, VSP_017478; Name=4; IsoId=Q6P1G2-4; Sequence=VSP_019003; The LRR repeats are required for the interaction with the PCGF1-BCORL1 heterodimeric complex. The JmjC domain mediates demethylation activity (By similarity). It is also required for repression of ribosomal RNA genes (By similarity). The CXXC zinc finger mediates binding to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. The F-box domain mediates interaction with UBB. Belongs to the JHDM1 histone demethylase family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding RNA binding protein binding nucleus chromosome nucleolus chromatin organization spermatogenesis zinc ion binding oxidoreductase activity rRNA binding midbrain-hindbrain boundary morphogenesis fourth ventricle development lateral ventricle development third ventricle development initiation of neural tube closure positive regulation of cell growth forebrain development midbrain development hindbrain development PcG protein complex histone demethylase activity histone H2A monoubiquitination negative regulation of neuron apoptotic process metal ion binding embryonic camera-type eye morphogenesis dioxygenase activity histone demethylase activity (H3-K36 specific) oxidation-reduction process histone H3-K36 demethylation positive regulation of stem cell population maintenance negative regulation of neural precursor cell proliferation uc008zms.1 uc008zms.2 uc008zms.3 uc008zms.4 uc008zms.5 uc008zms.6 
ENSMUST00000046091.7 Elane ENSMUST00000046091.7 elastase, neutrophil expressed (from RefSeq NM_015779.2) A6H698 ELNE_MOUSE ENSMUST00000046091.1 ENSMUST00000046091.2 ENSMUST00000046091.3 ENSMUST00000046091.4 ENSMUST00000046091.5 ENSMUST00000046091.6 Ela2 NM_015779 Q3UP87 Q61515 uc007gai.1 uc007gai.2 uc007gai.3 This gene encodes a member of the chymotrypsin-like family of serine protease enzymes that hydrolyzes a broad range of protein substrates including elastin. This gene is expressed by neutrophils where the encoded enzyme is stored in azurophil granules. Upon neutrophil activation, the active enzyme is released into the extracellular mileu. Mice lacking the encoded protein exhibit increased susceptibility to sepsis and death following intraperitoneal infection with Gram negative bacteria. This gene is located adjacent to a related proteinase gene on chromosome 10. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK143710.1, BC145800.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (By similarity). Capable of killing E.coli; probably digests outer membrane protein A (ompA) in E.coli (PubMed:10947984). Reaction=Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.; EC=3.4.21.37; Evidence=; Interacts with NOTCH2NL. Mice with a homozygous knockout of this gene are more easily killed by wild-type E.coli, but the knockout has no visible killing effect on E.coli deleted for outer membrane protein A (ompA). Belongs to the peptidase S1 family. Elastase subfamily. negative regulation of transcription from RNA polymerase II promoter response to yeast protease binding acute inflammatory response to antigenic stimulus leukocyte migration involved in inflammatory response biosynthetic process of antibacterial peptides active against Gram-negative bacteria transcription corepressor activity endopeptidase activity serine-type endopeptidase activity extracellular space cytoplasm proteolysis phagocytosis heparin binding peptidase activity serine-type peptidase activity response to UV cell surface hydrolase activity transcriptional repressor complex cytokine binding secretory granule response to lipopolysaccharide defense response to bacterium negative regulation of chemokine biosynthetic process negative regulation of interleukin-8 biosynthetic process positive regulation of interleukin-8 biosynthetic process positive regulation of smooth muscle cell proliferation positive regulation of immune response defense response to fungus leukocyte migration neutrophil mediated killing of gram-negative bacterium neutrophil mediated killing of fungus positive regulation of leukocyte tethering or rolling uc007gai.1 uc007gai.2 uc007gai.3 
ENSMUST00000046093.6 Hmx3 ENSMUST00000046093.6 H6 homeobox 3 (from RefSeq NM_008257.3) B9EIJ0 ENSMUST00000046093.1 ENSMUST00000046093.2 ENSMUST00000046093.3 ENSMUST00000046093.4 ENSMUST00000046093.5 HMX3_MOUSE NM_008257 Nkx-5.1 Nkx5-1 O88699 P42581 uc009kbo.1 uc009kbo.2 uc009kbo.3 uc009kbo.4 uc009kbo.5 Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS. Nucleus Expressed in the developing CNS, including a specific expression in vestibular structures throughout inner ear development. Begins at embryonic day 10.5 in the developing ear, hypothalamus, the neural tube and dorsal root ganglia. It continues to be active throughout prenatal life in discrete regions of the brain with an anterior border in the ventral diencephalon at the optic chiasma and expression domains in mesencephalon, metencephalon, and myelencephalon. At midgestation, it is also expressed in mesenchyme of the head and branchial arches, and in some cranial ganglia, as well as in derivatives of neural crest, such as the truncus sympathicus and myenteric ganglia. In inner ear, it is expressed between 13.5 dpc and birth in non-sensory epithelium of the semicircular canals, utricle and saccule. Also expressed in the cochlea, where the expression is restricted to the stria vascularis. Regulated by Six1 and FGFs in inner ear. Mice display abnormal circling behavior and severe vestibular defects owing to a depletion of sensory cells in the saccule and utricle, and a complete loss of the horizontal semicircular canal crista, as well as a fusion of the utricle and saccule endolymphatic spaces into a common utriculosaccular cavity. Moreover, most females have a reproductive defect: females can be fertilized and their embryos undergo normal preimplantation development, but the embryos fail to implant successfully in the uterus and subsequently die. Mice lacking both Hmx2 and Hmx3 show a complete loss of balance, postnatal dwarfism, defects in neuroendocrine system, disturbed hypothalamic-pituitary axis and subsequent die. Defects caused in mice lacking both Hmx2 and Hmx3 can be rescued by expressing the Drosophila Hmx protein. Belongs to the HMX homeobox family. Sequence=CAA53079.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development nervous system development brain development embryo implantation cell differentiation inner ear morphogenesis sequence-specific DNA binding ear development neuromuscular process controlling balance maternal process involved in female pregnancy uc009kbo.1 uc009kbo.2 uc009kbo.3 uc009kbo.4 uc009kbo.5 
ENSMUST00000046094.6 Ppp1ca ENSMUST00000046094.6 protein phosphatase 1 catalytic subunit alpha (from RefSeq NM_031868.2) ENSMUST00000046094.1 ENSMUST00000046094.2 ENSMUST00000046094.3 ENSMUST00000046094.4 ENSMUST00000046094.5 NM_031868 P08129 P20653 P22802 P62137 PP1A_MOUSE Ppp1a Q3U7G7 Q9Z1G2 uc008fzg.1 uc008fzg.2 uc008fzg.3 uc008fzg.4 Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation- induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates CENPA (By similarity). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Note=Binds 1 Fe cation per subunit. ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with PPP1R9A, PPP1R9B and PPP1R7. Interacts with PPP1R15A; the interaction mediates binding to EIF2S1. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5. Interacts with NOM1 and PPP1R8. Interacts with PPP1R16B. Interacts. with RPSA only in the presence of PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS. Interacts with PPP1R39. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824' and forms a complex at the p21 promoter site (By similarity). Interacts with PPP1R15B; the interaction mediates binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with NEK2. Interacts with FER; this promotes phosphorylation at Thr-320 (By similarity). Interacts with PHACTR4; which acts as an activator of PP1 activity. Interacts with BTBD10 (PubMed:18160256). Interacts with KCTD20 (PubMed:24156551). Interacts with FOXP3 (By similarity). Interacts with CENPA (By similarity). Interacts with ATG16L1 (By similarity). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (By similarity). Interacts with tensin TNS1 (By similarity). Interacts with SAXO4, PPP1R21, PPP1R26, PPP1R27, PPP1R35, PPP1R36, PPP1R37, SH3RF2, ELFN1 and ELFN2 (By similarity). P62137; O35625: Axin1; NbExp=2; IntAct=EBI-357187, EBI-2365912; P62137; Q9WTL8: Bmal1; NbExp=2; IntAct=EBI-357187, EBI-644534; P62137; P41136: Id2; NbExp=2; IntAct=EBI-357187, EBI-309167; P62137; P17918: Pcna; NbExp=2; IntAct=EBI-357187, EBI-1173716; P62137; Q3UM45: Ppp1r7; NbExp=3; IntAct=EBI-357187, EBI-8318179; P62137; Q9WTX5: Skp1; NbExp=2; IntAct=EBI-357187, EBI-1202363; Cytoplasm Nucleus Nucleus, nucleoplasm Nucleus, nucleolus Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles (By similarity). Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation (By similarity). Belongs to the PPP phosphatase family. PP-1 subfamily. Name=Protein Spotlight; Note=The things we forget - Issue 32 of March 2003; URL="https://web.expasy.org/spotlight/back_issues/032"; protein phosphatase type 1 complex nuclear chromosome, telomeric region phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol plasma membrane cell-cell adherens junction carbohydrate metabolic process glycogen metabolic process regulation of glycogen biosynthetic process regulation of glycogen catabolic process regulation of translation protein dephosphorylation cell cycle protein phosphatase 1 binding cellular process response to lead ion dephosphorylation hydrolase activity phosphatase activity lung development circadian regulation of gene expression glycogen granule regulation of circadian rhythm neuron projection ribonucleoprotein complex binding neuronal cell body entrainment of circadian clock by photoperiod dendritic spine perikaryon macromolecular complex binding metal ion binding rhythmic process branching morphogenesis of an epithelial tube cell division PTW/PP1 phosphatase complex cell-cell adhesion cadherin binding involved in cell-cell adhesion presynapse postsynapse glutamatergic synapse positive regulation of extrinsic apoptotic signaling pathway in absence of ligand uc008fzg.1 uc008fzg.2 uc008fzg.3 uc008fzg.4 
ENSMUST00000046095.10 Vsx1 ENSMUST00000046095.10 visual system homeobox 1 (from RefSeq NM_054068.2) ENSMUST00000046095.1 ENSMUST00000046095.2 ENSMUST00000046095.3 ENSMUST00000046095.4 ENSMUST00000046095.5 ENSMUST00000046095.6 ENSMUST00000046095.7 ENSMUST00000046095.8 ENSMUST00000046095.9 NM_054068 Q91V10 Rinx VSX1_MOUSE uc008muh.1 uc008muh.2 uc008muh.3 uc008muh.4 Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster (By similarity). May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (PubMed:17919464). Nucleus Expressed in the postnatal retina (at protein level) (PubMed:17919464). In the adult, expressed exclusively in the cells of the neural retina with expression restricted to postnatal cone bipolar interneurons (PubMed:15838724). Expressed at P5, solely within the inner nuclear layer (INL) of the central neuroretina. By days P6 and P7, expression expands peripherally during neurogenesis. By P12, expression is restricted to the outer margin of the INL and reaches the outer periphery of the neuroretina. At embryonic day 14.5 ocular morphology is normal as is expression and localization of retinal transcription and cell cycle regulatory proteins. Belongs to the paired homeobox family. DNA binding chromatin binding nucleus regulation of transcription, DNA-templated multicellular organism development visual perception neuron maturation sequence-specific DNA binding transcription regulatory region DNA binding neuron development response to stimulus retinal bipolar neuron differentiation uc008muh.1 uc008muh.2 uc008muh.3 uc008muh.4 
ENSMUST00000046110.16 Astn1 ENSMUST00000046110.16 astrotactin 1, transcript variant 2 (from RefSeq NM_007495.5) ASTN1_MOUSE Astn ENSMUST00000046110.1 ENSMUST00000046110.10 ENSMUST00000046110.11 ENSMUST00000046110.12 ENSMUST00000046110.13 ENSMUST00000046110.14 ENSMUST00000046110.15 ENSMUST00000046110.2 ENSMUST00000046110.3 ENSMUST00000046110.4 ENSMUST00000046110.5 ENSMUST00000046110.6 ENSMUST00000046110.7 ENSMUST00000046110.8 ENSMUST00000046110.9 G5E8A1 Kiaa0289 NM_007495 Q505A0 Q61137 Q7TQG3 Q8CHH2 uc007ddt.1 uc007ddt.2 uc007ddt.3 uc007ddt.4 uc007ddt.5 Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development. Interacts with ASTN2; the interaction is not calcium- dependent. Cell membrane ulti-pass membrane protein Perikaryon Endosome Cytoplasmic vesicle, clathrin-coated vesicle Note=Detected close to the anterior pole and at the base of the leading process in migrating neurons. Is internalized from the membrane via clathrin-coated vesicles and endosomes, and recycled to the anterior pole of the migrating cell. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61137-1; Sequence=Displayed; Name=2; IsoId=Q61137-2; Sequence=VSP_014917; Detected in brain (at protein level) (PubMed:11861479). Expressed specifically in the brain. Expressed in the cerebellum, hippocampus, cerebrum and olfactory bulb (PubMed:8602532). First detected in embryonic brain at 12 dpc. Expression increases thereafter, is highest in brain from pups 4 days after birth, and then decreases again. Expression is decreased 14 days after birth, and not detectable in adult brain. Slower than normal migration of granule cells in the developing cerebellum, leading to a decreased cerebellum size in adult mice and impaired skills in tasks that require coordinated movement and balance. Granule cells from mutant mice have a rounded shape and lack the elongated shape seen in wild-type. At 6 days after birth, increased granule cell apoptosis is observed, contrary to the situation in wild-type. Belongs to the astrotactin family. Sequence=AAC52516.1; Type=Frameshift; Evidence=; neuron migration protein binding endosome plasma membrane cell adhesion neuron cell-cell adhesion locomotory behavior external side of plasma membrane membrane integral component of membrane cell migration clathrin-coated vesicle cytoplasmic vesicle perikaryon cell-cell adhesion uc007ddt.1 uc007ddt.2 uc007ddt.3 uc007ddt.4 uc007ddt.5 
ENSMUST00000046114.5 Mrpl54 ENSMUST00000046114.5 mitochondrial ribosomal protein L54 (from RefSeq NM_025317.2) ENSMUST00000046114.1 ENSMUST00000046114.2 ENSMUST00000046114.3 ENSMUST00000046114.4 NM_025317 Q9CPW3 RM54_MOUSE uc007ggy.1 uc007ggy.2 uc007ggy.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mL54 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome biological_process uc007ggy.1 uc007ggy.2 uc007ggy.3 
ENSMUST00000046122.11 Lap3 ENSMUST00000046122.11 leucine aminopeptidase 3 (from RefSeq NM_024434.6) AMPL_MOUSE ENSMUST00000046122.1 ENSMUST00000046122.10 ENSMUST00000046122.2 ENSMUST00000046122.3 ENSMUST00000046122.4 ENSMUST00000046122.5 ENSMUST00000046122.6 ENSMUST00000046122.7 ENSMUST00000046122.8 ENSMUST00000046122.9 Lap3 Lapep NM_024434 Q3TFS5 Q4FJV1 Q4FK15 Q99P44 Q9CPY7 Q9CWN8 uc008xiy.1 uc008xiy.2 uc008xiy.3 Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S- conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. Reaction=Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.; EC=3.4.11.1; Evidence=; Reaction=an S-substituted L-cysteinylglycine + H2O = an S-substituted L-cysteine + glycine; Xref=Rhea:RHEA:60444, ChEBI:CHEBI:15377, ChEBI:CHEBI:57305, ChEBI:CHEBI:58717, ChEBI:CHEBI:143103; EC=3.4.13.23; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60445; Evidence=; Reaction=H2O + L-cysteinylglycine = glycine + L-cysteine; Xref=Rhea:RHEA:28783, ChEBI:CHEBI:15377, ChEBI:CHEBI:35235, ChEBI:CHEBI:57305, ChEBI:CHEBI:61694; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28784; Evidence=; Reaction=H2O + S-benzyl-L-cysteinylglycine = glycine + S-benzyl-L- cysteine; Xref=Rhea:RHEA:62568, ChEBI:CHEBI:15377, ChEBI:CHEBI:57305, ChEBI:CHEBI:145802, ChEBI:CHEBI:145803; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62569; Evidence=; Reaction=Release of N-terminal proline from a peptide.; EC=3.4.11.5; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds two metal ions per subunit. Two metal binding sites with different affinities are located in the enzyme active site and can be occupied in vitro by different metals: site 1 is occupied by Zn(2+), Mn(2+), Mg(2+) or Co(2+), while the tight binding site 2 can be occupied by only Zn(2+) or Co(2+). One Zn(2+) ion is tightly bound to site 2 and essential for enzyme activity in vivo, while site 1 can be occupied by different metals to give different enzymatic activities. Mn(2+) is required for Cys-Gly hydrolysis activity. A third metal binding site may serve a structural role, possibly stabilizing part of the interface between the N-terminal and the catalytic domain. ; Homohexamer. Cytoplasm Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=Q9CPY7-1; Sequence=Displayed; Name=2; IsoId=Q9CPY7-2; Sequence=VSP_022632; Belongs to the peptidase M17 family. Sequence=BAB23958.1; Type=Erroneous initiation; Evidence=; Sequence=BAB25769.1; Type=Erroneous initiation; Evidence=; Sequence=BAB27726.1; Type=Erroneous initiation; Evidence=; Sequence=BAE39141.1; Type=Erroneous initiation; Evidence=; Sequence=BAE40823.1; Type=Erroneous initiation; Evidence=; aminopeptidase activity nucleoplasm cytoplasm mitochondrion trans-Golgi network cytosol proteolysis peptidase activity metalloexopeptidase activity hydrolase activity protein metabolic process manganese ion binding midbody metal ion binding uc008xiy.1 uc008xiy.2 uc008xiy.3 
ENSMUST00000046128.12 Uroc1 ENSMUST00000046128.12 urocanase domain containing 1, transcript variant 2 (from RefSeq NM_144940.2) E9QNN2 ENSMUST00000046128.1 ENSMUST00000046128.10 ENSMUST00000046128.11 ENSMUST00000046128.2 ENSMUST00000046128.3 ENSMUST00000046128.4 ENSMUST00000046128.5 ENSMUST00000046128.6 ENSMUST00000046128.7 ENSMUST00000046128.8 ENSMUST00000046128.9 HUTU_MOUSE NM_144940 Q8VC12 uc009cxc.1 uc009cxc.2 uc009cxc.3 uc009cxc.4 uc009cxc.5 Reaction=4-imidazolone-5-propanoate = H2O + trans-urocanate; Xref=Rhea:RHEA:13101, ChEBI:CHEBI:15377, ChEBI:CHEBI:17771, ChEBI:CHEBI:77893; EC=4.2.1.49; Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence=; Amino-acid degradation; L-histidine degradation into L- glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3. Belongs to the urocanase family. cytosol histidine metabolic process histidine catabolic process urocanate hydratase activity lyase activity histidine catabolic process to glutamate and formamide histidine catabolic process to glutamate and formate uc009cxc.1 uc009cxc.2 uc009cxc.3 uc009cxc.4 uc009cxc.5 
ENSMUST00000046131.16 H2-T9 ENSMUST00000046131.16 Involved in the presentation of foreign antigens to the immune system. (from UniProt Q0WXH6) AB267093 E9PV42 E9Q5B3 EG630294 ENSMUST00000046131.1 ENSMUST00000046131.10 ENSMUST00000046131.11 ENSMUST00000046131.12 ENSMUST00000046131.13 ENSMUST00000046131.14 ENSMUST00000046131.15 ENSMUST00000046131.2 ENSMUST00000046131.3 ENSMUST00000046131.4 ENSMUST00000046131.5 ENSMUST00000046131.6 ENSMUST00000046131.7 ENSMUST00000046131.8 ENSMUST00000046131.9 Gm11127 Gm7030 H2-T25 H2-T9 Q0WXH6 Q0WXH6_MOUSE uc289kte.1 uc289kte.2 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane peptide antigen binding uc289kte.1 uc289kte.2 
ENSMUST00000046157.10 Fndc3b ENSMUST00000046157.10 fibronectin type III domain containing 3B, transcript variant 1 (from RefSeq NM_173182.3) A0A0R4J0H8 A0A0R4J0H8_MOUSE ENSMUST00000046157.1 ENSMUST00000046157.2 ENSMUST00000046157.3 ENSMUST00000046157.4 ENSMUST00000046157.5 ENSMUST00000046157.6 ENSMUST00000046157.7 ENSMUST00000046157.8 ENSMUST00000046157.9 Fndc3b NM_173182 uc008otp.1 uc008otp.2 uc008otp.3 membrane integral component of membrane uc008otp.1 uc008otp.2 uc008otp.3 
ENSMUST00000046168.12 Mpped1 ENSMUST00000046168.12 metallophosphoesterase domain containing 1, transcript variant 11 (from RefSeq NR_183244.1) A6PW09 D15Bwg0669e ENSMUST00000046168.1 ENSMUST00000046168.10 ENSMUST00000046168.11 ENSMUST00000046168.2 ENSMUST00000046168.3 ENSMUST00000046168.4 ENSMUST00000046168.5 ENSMUST00000046168.6 ENSMUST00000046168.7 ENSMUST00000046168.8 ENSMUST00000046168.9 MPPD1_MOUSE NR_183244 Q3TMS4 Q3TYC7 Q91ZG2 uc007xbk.1 uc007xbk.2 uc007xbk.3 May have metallophosphoesterase activity (in vitro). Belongs to the UPF0046 family. molecular_function cellular_component biological_process hydrolase activity uc007xbk.1 uc007xbk.2 uc007xbk.3 
ENSMUST00000046174.8 Cldn11 ENSMUST00000046174.8 claudin 11 (from RefSeq NM_008770.3) CLD11_MOUSE ENSMUST00000046174.1 ENSMUST00000046174.2 ENSMUST00000046174.3 ENSMUST00000046174.4 ENSMUST00000046174.5 ENSMUST00000046174.6 ENSMUST00000046174.7 NM_008770 Osp Otm Q545N5 Q60771 Q9DB65 uc008ovw.1 uc008ovw.2 uc008ovw.3 uc008ovw.4 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of CNS (central nervous system) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. The basal cell tight junctions in stria vascularis are primarily composed of this protein, and the gene-null mice suffer severe deafness. This protein is also an obligatory protein for tight junction formation and barrier integrity in the testis and the gene deficiency results in loss of the Sertoli cell epithelial phenotype in the testis. [provided by RefSeq, Aug 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK005088.1, AK161698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Interacts with tetraspanin-3/TSPAN3 (PubMed:11309411). Interacts with OCLN (By similarity). Q60771; P07141: Csf1; NbExp=2; IntAct=EBI-309095, EBI-777188; Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein Belongs to the claudin family. structural molecule activity protein binding plasma membrane integral component of plasma membrane bicellular tight junction cell adhesion spermatogenesis axon ensheathment membrane integral component of membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding myelin sheath basal part of cell uc008ovw.1 uc008ovw.2 uc008ovw.3 uc008ovw.4 
ENSMUST00000046186.8 Spon2 ENSMUST00000046186.8 spondin 2, extracellular matrix protein (from RefSeq NM_133903.3) ENSMUST00000046186.1 ENSMUST00000046186.2 ENSMUST00000046186.3 ENSMUST00000046186.4 ENSMUST00000046186.5 ENSMUST00000046186.6 ENSMUST00000046186.7 NM_133903 Q6SJD8 Q8BMS2 SPON2_MOUSE uc008xai.1 uc008xai.2 uc008xai.3 uc008xai.4 Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Binds bacterial lipopolysaccharide. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens. Monomer. Interacts with integrin (By similarity). Secreted, extracellular space, extracellular matrix Detected in heart, lung, thymus, spleen and lymph node. lipopolysaccharide binding immune system process mast cell mediated immunity antigen binding receptor binding protein binding extracellular region extracellular space cell adhesion opsonization extracellular matrix response to lipopolysaccharide positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production defense response to bacterium induction of bacterial agglutination innate immune response metal ion binding defense response to fungus defense response to virus positive regulation of macrophage cytokine production cellular response to lipopolysaccharide uc008xai.1 uc008xai.2 uc008xai.3 uc008xai.4 
ENSMUST00000046191.9 Gnpnat1 ENSMUST00000046191.9 glucosamine-phosphate N-acetyltransferase 1, transcript variant 5 (from RefSeq NM_019425.3) ENSMUST00000046191.1 ENSMUST00000046191.2 ENSMUST00000046191.3 ENSMUST00000046191.4 ENSMUST00000046191.5 ENSMUST00000046191.6 ENSMUST00000046191.7 ENSMUST00000046191.8 GNA1_MOUSE Gna1 NM_019425 Q9JK38 uc007tgp.1 uc007tgp.2 uc007tgp.3 Reaction=acetyl-CoA + D-glucosamine 6-phosphate = CoA + H(+) + N- acetyl-D-glucosamine 6-phosphate; Xref=Rhea:RHEA:10292, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57513, ChEBI:CHEBI:58725; EC=2.3.1.4; Evidence=; Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2. Homodimer. Golgi apparatus membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Ubiquitous. Shows a strong differential expression pattern in adult hematopoietic precursor cells. Widely expressed at early stages of embryonic development but is confined to bones, skin and the hematopoietic system at later developmental stages. Belongs to the acetyltransferase family. GNA1 subfamily. Golgi membrane liver development glucosamine 6-phosphate N-acetyltransferase activity endosome late endosome endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus glucosamine metabolic process N-acetylglucosamine metabolic process UDP-N-acetylglucosamine biosynthetic process N-acetyltransferase activity endosome membrane membrane transferase activity transferase activity, transferring acyl groups identical protein binding monosaccharide binding cellular response to leukemia inhibitory factor uc007tgp.1 uc007tgp.2 uc007tgp.3 
ENSMUST00000046206.5 Rprd1a ENSMUST00000046206.5 regulation of nuclear pre-mRNA domain containing 1A, transcript variant 1 (from RefSeq NM_144861.2) ENSMUST00000046206.1 ENSMUST00000046206.2 ENSMUST00000046206.3 ENSMUST00000046206.4 Kiaa4077 NM_144861 P15rs Q5DTP5 Q8VDS4 RPR1A_MOUSE uc008egu.1 uc008egu.2 uc008egu.3 Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. May form a heterodimer with RPRD1B. Associates with the RNA polymerase II subunit POLR2A (via CTD phosphorylated at 'Ser-2' and 'Ser-7' of the heptad repeats). Nucleus Belongs to the UPF0400 (RTT103) family. Sequence=BAD90282.1; Type=Erroneous initiation; Evidence=; RNA polymerase II core binding DNA-directed RNA polymerase II, holoenzyme mRNA 3'-end processing identical protein binding dephosphorylation of RNA polymerase II C-terminal domain uc008egu.1 uc008egu.2 uc008egu.3 
ENSMUST00000046207.9 Sf3b6 ENSMUST00000046207.9 splicing factor 3B, subunit 6 (from RefSeq NM_025323.2) ENSMUST00000046207.1 ENSMUST00000046207.2 ENSMUST00000046207.3 ENSMUST00000046207.4 ENSMUST00000046207.5 ENSMUST00000046207.6 ENSMUST00000046207.7 ENSMUST00000046207.8 NM_025323 P59708 Q3U9T9 SF3B6_MOUSE Sf3b14 uc007myi.1 uc007myi.2 uc007myi.3 Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre- mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B6 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Within the 17S U2 SnRNP complex, SF3B6 directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. SF3B6 stabilizes the intron branch site-U2 snRNA duplex, thereby promoting- binding of introns with poor sequence complementarity. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs. Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Part of the SF3B subcomplex of the 17S U2 SnRNP complex. SF3B associates with the splicing subcomplex SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Within the SF3B complex interacts directly with SF3B1. Component of the minor spliceosome, which splices U12-type introns. Nucleus mRNA splicing, via spliceosome blastocyst formation nucleic acid binding RNA binding mRNA binding nucleus spliceosomal complex U12-type spliceosomal complex mRNA processing RNA splicing uc007myi.1 uc007myi.2 uc007myi.3 
ENSMUST00000046212.2 Slc16a1 ENSMUST00000046212.2 solute carrier family 16 (monocarboxylic acid transporters), member 1 (from RefSeq NM_009196.4) ENSMUST00000046212.1 NM_009196 Q544N9 Q544N9_MOUSE Slc16a1 uc008qui.1 uc008qui.2 uc008qui.3 uc008qui.4 Reaction=(R)-3-hydroxybutanoate(out) + H(+)(out) = (R)-3- hydroxybutanoate(in) + H(+)(in); Xref=Rhea:RHEA:71795, ChEBI:CHEBI:10983, ChEBI:CHEBI:15378; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71796; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71797; Evidence=; Reaction=(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out); Xref=Rhea:RHEA:29415, ChEBI:CHEBI:15378, ChEBI:CHEBI:16651; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29416; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29417; Evidence=; Reaction=3-methyl-2-oxobutanoate(out) + H(+)(out) = 3-methyl-2- oxobutanoate(in) + H(+)(in); Xref=Rhea:RHEA:71783, ChEBI:CHEBI:11851, ChEBI:CHEBI:15378; Evidence=; Reaction=4-methyl-2-oxopentanoate(out) + H(+)(out) = 4-methyl-2- oxopentanoate(in) + H(+)(in); Xref=Rhea:RHEA:71779, ChEBI:CHEBI:15378, ChEBI:CHEBI:17865; Evidence=; Reaction=acetoacetate(out) + H(+)(out) = acetoacetate(in) + H(+)(in); Xref=Rhea:RHEA:71775, ChEBI:CHEBI:13705, ChEBI:CHEBI:15378; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71776; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71777; Evidence=; Apical cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Lateral cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein centrosome plasma membrane integral component of plasma membrane centrosome cycle monocarboxylic acid transmembrane transporter activity lactate transmembrane transporter activity monocarboxylic acid transport membrane integral component of membrane cell junction lactate transmembrane transport plasma membrane lactate transport protein homodimerization activity intracellular membrane-bounded organelle transmembrane transport cellular response to organic cyclic compound organic cyclic compound binding uc008qui.1 uc008qui.2 uc008qui.3 uc008qui.4 
ENSMUST00000046221.8 Pln ENSMUST00000046221.8 phospholamban, transcript variant 2 (from RefSeq NM_023129.5) ENSMUST00000046221.1 ENSMUST00000046221.2 ENSMUST00000046221.3 ENSMUST00000046221.4 ENSMUST00000046221.5 ENSMUST00000046221.6 ENSMUST00000046221.7 NM_023129 P20006 P61014 PPLA_MOUSE Pln Q3UQ75 uc007fbo.1 uc007fbo.2 uc007fbo.3 uc007fbo.4 Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (PubMed:22971924, PubMed:26816378). Controls intracellular Ca(2+) levels in elongated spermatids. May play a role in germ cell differentiation (PubMed:30733280). Homopentamer (PubMed:26644582). Interacts with HAX1. Interact with ATP2A2; the inhibition decreases ATP2A2 Ca(2+) affinity. Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2. Interacts with S100A1 in a Ca(2+)- dependent manner. P61014; P05132: Prkaca; NbExp=2; IntAct=EBI-10148373, EBI-400564; P61014; Q13557: CAMK2D; Xeno; NbExp=2; IntAct=EBI-10148373, EBI-351018; P61014; P61981: YWHAG; Xeno; NbExp=3; IntAct=EBI-10148373, EBI-359832; Endoplasmic reticulum membrane ; Single-pass membrane protein Sarcoplasmic reticulum membrane ; Single-pass membrane protein Mitochondrion membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein Note=Colocalizes with HAX1 at the endoplasmic reticulum. Colocalizes with DMPK a the sarcoplasmic reticulum. Expressed in testis (at protein level). Phosphorylated at Thr-17 by CaMK2, and in response to beta- adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes (By similarity). Phosphorylation by PKA abolishes the inhibition of ATP2A2- mediated calcium uptake. Palmitoylated by ZDHHC16, promoting formation of the homopentamer. In elongated spermatids, proteolytically cleaved by SPPL2C which modulates intracellular Ca(2+) homeostasis. Belongs to the phospholamban family. regulation of the force of heart contraction calcium channel regulator activity protein binding mitochondrion endoplasmic reticulum endoplasmic reticulum membrane calcium ion transport cellular calcium ion homeostasis Notch signaling pathway regulation of heart contraction response to zinc ion negative regulation of heart rate regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion membrane integral component of membrane sarcoplasmic reticulum mitochondrial membrane vesicle negative regulation of ATPase activity response to insulin macromolecular complex sarcoplasmic reticulum membrane response to testosterone ATPase inhibitor activity protein homodimerization activity negative regulation of heart contraction cardiac muscle tissue development protein homooligomerization regulation of calcium ion transport negative regulation of calcium ion transport regulation of ryanodine-sensitive calcium-release channel activity regulation of cardiac muscle cell contraction adrenergic receptor signaling pathway involved in heart process regulation of the force of heart contraction by cardiac conduction regulation of calcium ion import calcium ion-transporting ATPase complex negative regulation of calcium ion transmembrane transporter activity regulation of relaxation of muscle negative regulation of calcium ion binding regulation of calcium-transporting ATPase activity negative regulation of calcium-transporting ATPase activity negative regulation of calcium ion import into sarcoplasmic reticulum uc007fbo.1 uc007fbo.2 uc007fbo.3 uc007fbo.4 
ENSMUST00000046233.9 Bbox1 ENSMUST00000046233.9 gamma-butyrobetaine hydroxylase 1, transcript variant 3 (from RefSeq NR_182116.1) BODG_MOUSE ENSMUST00000046233.1 ENSMUST00000046233.2 ENSMUST00000046233.3 ENSMUST00000046233.4 ENSMUST00000046233.5 ENSMUST00000046233.6 ENSMUST00000046233.7 ENSMUST00000046233.8 NR_182116 Q924Y0 uc008lmu.1 uc008lmu.2 uc008lmu.3 Catalyzes the formation of L-carnitine from gamma- butyrobetaine. Reaction=2-oxoglutarate + 4-(trimethylamino)butanoate + O2 = carnitine + CO2 + succinate; Xref=Rhea:RHEA:24028, ChEBI:CHEBI:15379, ChEBI:CHEBI:16244, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:17126, ChEBI:CHEBI:30031; EC=1.14.11.1; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Amine and polyamine biosynthesis; carnitine biosynthesis. Cytoplasm Belongs to the gamma-BBH/TMLD family. iron ion binding cytoplasm mitochondrion zinc ion binding gamma-butyrobetaine dioxygenase activity oxidoreductase activity identical protein binding carnitine biosynthetic process metal ion binding dioxygenase activity oxidation-reduction process uc008lmu.1 uc008lmu.2 uc008lmu.3 
ENSMUST00000046234.5 Lce3b ENSMUST00000046234.5 late cornified envelope 3B (from RefSeq NM_025501.4) ENSMUST00000046234.1 ENSMUST00000046234.2 ENSMUST00000046234.3 ENSMUST00000046234.4 Lce3b NM_025501 Q9CQM7 Q9CQM7_MOUSE uc008qew.1 uc008qew.2 uc008qew.3 Belongs to the LCE family. epidermis development uc008qew.1 uc008qew.2 uc008qew.3 
ENSMUST00000046244.15 Dxo ENSMUST00000046244.15 Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. (from UniProt A0A0R4J288) A0A0R4J288 A0A0R4J288_MOUSE BC004713 Dxo ENSMUST00000046244.1 ENSMUST00000046244.10 ENSMUST00000046244.11 ENSMUST00000046244.12 ENSMUST00000046244.13 ENSMUST00000046244.14 ENSMUST00000046244.2 ENSMUST00000046244.3 ENSMUST00000046244.4 ENSMUST00000046244.5 ENSMUST00000046244.6 ENSMUST00000046244.7 ENSMUST00000046244.8 ENSMUST00000046244.9 uc008cdr.1 uc008cdr.2 uc008cdr.3 uc008cdr.4 Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. Reaction=a 5'-end CoA-ribonucleoside in mRNA + H2O = 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+); Xref=Rhea:RHEA:67496, Rhea:RHEA-COMP:15692, Rhea:RHEA-COMP:17276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57328, ChEBI:CHEBI:138282, ChEBI:CHEBI:172371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67497; Evidence=; Reaction=a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+); Xref=Rhea:RHEA:67492, Rhea:RHEA-COMP:15692, Rhea:RHEA-COMP:17275, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:138282, ChEBI:CHEBI:172372; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67493; Evidence=; Reaction=a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O = a 5'- end phospho-ribonucleoside in snoRNA + H(+) + NAD(+); Xref=Rhea:RHEA:60892, Rhea:RHEA-COMP:15699, Rhea:RHEA-COMP:15700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:138282, ChEBI:CHEBI:144029; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60893; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions. ; Nucleus Belongs to the DXO/Dom3Z family. nucleus cytosol plasma membrane uc008cdr.1 uc008cdr.2 uc008cdr.3 uc008cdr.4 
ENSMUST00000046246.13 Pdlim7 ENSMUST00000046246.13 PDZ and LIM domain 7, transcript variant a (from RefSeq NM_001114088.2) ENSMUST00000046246.1 ENSMUST00000046246.10 ENSMUST00000046246.11 ENSMUST00000046246.12 ENSMUST00000046246.2 ENSMUST00000046246.3 ENSMUST00000046246.4 ENSMUST00000046246.5 ENSMUST00000046246.6 ENSMUST00000046246.7 ENSMUST00000046246.8 ENSMUST00000046246.9 Enigma NM_001114088 PDLI7_MOUSE Q3TJD7 Q80ZY6 Q810S3 Q8C1S4 Q9CRA1 uc007qrg.1 uc007qrg.2 uc007qrg.3 uc007qrg.4 uc007qrg.5 May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). Specifically binds via its LIM zinc-binding 3 domain (LIM 3) domain to endocytic codes of INSR, but not with those of IGF1R, LDLR, TFRC, or EGFR. Interacts with various PKC isoforms through the LIM zinc-binding domains. Binds to RET in a phosphorylation-independent manner via its LIM zinc-binding domain 2 (LIM 2). Probably part of a complex with SHC and the RET dimer. Interacts with TPM2, TBX4 and TBX5 (By similarity). Cytoplasm Cytoplasm, cytoskeleton Note=Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Colocalizes with TBX4 and TBX5 to actin filaments (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=LMP-1; IsoId=Q3TJD7-1; Sequence=Displayed; Name=2; IsoId=Q3TJD7-2; Sequence=VSP_016517, VSP_016520, VSP_016521; Name=3; IsoId=Q3TJD7-3; Sequence=VSP_016518, VSP_016519; At 13.5 dpc expressed in epaxial, intercostal, and other skeletal muscles at the brachial level, including the latissimus dorsi muscle. Expressed in the intrinsic and extrinsic muscle mass of the tongue. At 15 dpc expressed in mesenchymal tissue surrounding the cartilaginous anlage of immature bones, and in the future joint spaces. As endochondral ossification progresses, and the hypertrophic cartilage zone is replaced by mineralized bone, expression appears in the mineralizing portion of the bone. Expressed in mesoderm derived bones of the skull base and neural crest-derived endochondral bones such as the proximal mandible. The LIM zinc-binding 2 domain (LIM 2) interacts with TBX4. The LIM zinc-binding 3 domain (LIM 3) provides the structural basis for recognition of tyrosine-containing tight turn structures. This domain is necessary and sufficient for interaction with TBX5 (By similarity). Anchored to cell periphery via its N-terminal PDZ domain. ossification stress fiber ruffle actin binding protein binding nucleus cytoplasm cytoskeleton cell-cell adherens junction focal adhesion multicellular organism development heart development actin cytoskeleton Z disc actin cytoskeleton organization cell differentiation filamentous actin positive regulation of osteoblast differentiation metal ion binding muscle alpha-actinin binding muscle structure development uc007qrg.1 uc007qrg.2 uc007qrg.3 uc007qrg.4 uc007qrg.5 
ENSMUST00000046254.3 Lrfn2 ENSMUST00000046254.3 leucine rich repeat and fibronectin type III domain containing 2 (from RefSeq NM_027452.3) B9EIF8 ENSMUST00000046254.1 ENSMUST00000046254.2 Kiaa1246 LRFN2_MOUSE NM_027452 Q80TG9 Q9CYK3 Salm1 uc008cyd.1 uc008cyd.2 uc008cyd.3 uc008cyd.4 Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A (By similarity). May play a role in redistributing DLG4 to the cell periphery. Forms heteromeric complexes with LRFN1, LRFN3, LRFN4 and LRFN5. Can form homomeric complexes, but not across cell junctions (By similarity). Interacts with DLG4. Directly interacts with DLG1, DLG2 and DLG3 (By similarity). Directly interacts with 2 NMDA receptor subunits GRIN1 and GRIN2A (By similarity). Q80TG9; Q811D0: Dlg1; NbExp=3; IntAct=EBI-877092, EBI-514290; Q80TG9; Q62108: Dlg4; NbExp=3; IntAct=EBI-877092, EBI-300895; Q80TG9; P35439: Grin1; Xeno; NbExp=2; IntAct=EBI-877092, EBI-877897; Q80TG9; P35439-1: Grin1; Xeno; NbExp=2; IntAct=EBI-877092, EBI-877923; Q80TG9; P35439-4: Grin1; Xeno; NbExp=2; IntAct=EBI-877092, EBI-877935; Membrane ; Single- pass type I membrane protein Synapse Postsynaptic cell membrane Predominantly expressed in the brain, with a weak, but broad expression in the cerebral cortex and diencephalic nuclei. Strongly expressed in both the pyramidal layer and the dentate gyrus of the hippocampus. Also detected in other parts of the central nervous system, including the olfactory bulb, pons, cerebellum, and medulla oblongata, as well as in the peripheral nervous system, such as the ganglia of cranial nerves and the dorsal root ganglion during gestation. Expression starts around 11.5-12.5 dpc. At 11.5 dpc, detected in the outer layer of the telencephalic vesicles. This pattern of expression continues until 17.5 dpc with expression in the cortical plate, but not in the inner layer of the cerebral cortex, including subplate, ventricular zone, and subventricular zone. As also detected in the hippocampus, amygdala and widely in diencephalic nuclei. The PDZ-binding motif is required for cell surface expression, neurite outgrowth promotion and interaction with DLG1, DLG3 and DLG4. Glycosylated. Belongs to the LRFN family. Sequence=BAC65758.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding plasma membrane cell surface membrane integral component of membrane cell junction synapse postsynaptic membrane modulation of synaptic transmission integral component of postsynaptic density membrane uc008cyd.1 uc008cyd.2 uc008cyd.3 uc008cyd.4 
ENSMUST00000046255.14 Gpr19 ENSMUST00000046255.14 G protein-coupled receptor 19, transcript variant 7 (from RefSeq NM_001167699.2) ENSMUST00000046255.1 ENSMUST00000046255.10 ENSMUST00000046255.11 ENSMUST00000046255.12 ENSMUST00000046255.13 ENSMUST00000046255.2 ENSMUST00000046255.3 ENSMUST00000046255.4 ENSMUST00000046255.5 ENSMUST00000046255.6 ENSMUST00000046255.7 ENSMUST00000046255.8 ENSMUST00000046255.9 GPR19_MOUSE NM_001167699 Q61121 Q810I4 Q8VDJ9 uc009ekw.1 uc009ekw.2 uc009ekw.3 uc009ekw.4 uc009ekw.5 Orphan receptor. Cell membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61121-1; Sequence=Displayed; Name=2; IsoId=Q61121-2; Sequence=VSP_016527; Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane cilium signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009ekw.1 uc009ekw.2 uc009ekw.3 uc009ekw.4 uc009ekw.5 
ENSMUST00000046266.13 Mideas ENSMUST00000046266.13 mitotic deacetylase associated SANT domain protein, transcript variant 2 (from RefSeq NM_001163501.1) C130039O16Rik E9Q2I4 E9Q2I4_MOUSE ENSMUST00000046266.1 ENSMUST00000046266.10 ENSMUST00000046266.11 ENSMUST00000046266.12 ENSMUST00000046266.2 ENSMUST00000046266.3 ENSMUST00000046266.4 ENSMUST00000046266.5 ENSMUST00000046266.6 ENSMUST00000046266.7 ENSMUST00000046266.8 ENSMUST00000046266.9 Mideas NM_001163501 uc007oem.1 uc007oem.2 uc007oem.3 uc007oem.4 uc007oem.5 uc007oem.6 Nucleus histone deacetylase complex nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated transcription factor binding transcription regulatory region DNA binding uc007oem.1 uc007oem.2 uc007oem.3 uc007oem.4 uc007oem.5 uc007oem.6 
ENSMUST00000046283.16 Hspa13 ENSMUST00000046283.16 heat shock protein 70 family, member 13, transcript variant 1 (from RefSeq NM_030201.3) ENSMUST00000046283.1 ENSMUST00000046283.10 ENSMUST00000046283.11 ENSMUST00000046283.12 ENSMUST00000046283.13 ENSMUST00000046283.14 ENSMUST00000046283.15 ENSMUST00000046283.2 ENSMUST00000046283.3 ENSMUST00000046283.4 ENSMUST00000046283.5 ENSMUST00000046283.6 ENSMUST00000046283.7 ENSMUST00000046283.8 ENSMUST00000046283.9 HSP13_MOUSE NM_030201 Q3TII6 Q8BM72 Q9D1X5 Stch uc007zrp.1 uc007zrp.2 uc007zrp.3 uc007zrp.4 uc007zrp.5 Has peptide-independent ATPase activity. Binds UBQLN2. Microsome Endoplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BM72-1; Sequence=Displayed; Name=2; IsoId=Q8BM72-2; Sequence=VSP_013912, VSP_013913; Belongs to the heat shock protein 70 family. Sequence=BAE39860.1; Type=Erroneous initiation; Evidence=; nucleotide binding ATP binding nucleus cytoplasm endoplasmic reticulum cytosol plasma membrane response to unfolded protein vesicle-mediated transport ATPase activity heat shock protein binding cellular response to heat cellular response to unfolded protein protein refolding ATPase activity, coupled intracellular membrane-bounded organelle protein binding involved in protein folding unfolded protein binding chaperone mediated protein folding requiring cofactor misfolded protein binding uc007zrp.1 uc007zrp.2 uc007zrp.3 uc007zrp.4 uc007zrp.5 
ENSMUST00000046285.6 C1qa ENSMUST00000046285.6 complement component 1, q subcomponent, alpha polypeptide (from RefSeq NM_007572.2) C1QA_MOUSE ENSMUST00000046285.1 ENSMUST00000046285.2 ENSMUST00000046285.3 ENSMUST00000046285.4 ENSMUST00000046285.5 NM_007572 P98086 Q9DCM6 uc008vir.1 uc008vir.2 uc008vir.3 C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain. Interacts (via C-terminus) with CD33; this interaction activates CD33 inhibitory motifs. Interacts with CR1 (via Sushi 24 and Sushi 25 domains). Antigen-bound IgM (via the Fc region) interacts with the globular domains of C1q component of the complement system, all three modules C1QA, C1QB and C1QC being involved in IgM binding; this interaction is multivalent. It initiates the classical complement pathway. P98086; Q9H461: FZD8; Xeno; NbExp=3; IntAct=EBI-299840, EBI-6254212; Secreted. O-linked glycans are Glc-Gal disaccharides typically found as secondary modifications of hydroxylated lysines in collagen-like domains. Proline residues in the collagen-like domain motif, GXPG, are typically 4-hydroxylated. microglial cell activation immune system process protein binding extracellular region collagen trimer extracellular space cell complement activation, classical pathway aging response to iron ion neuron remodeling innate immune response synapse astrocyte activation synapse organization postsynapse synapse disassembly positive regulation of neuron death uc008vir.1 uc008vir.2 uc008vir.3 
ENSMUST00000046290.3 Lpcat2 ENSMUST00000046290.3 lysophosphatidylcholine acyltransferase 2, transcript variant 1 (from RefSeq NM_173014.2) A3KBM0 A9Q1G2 A9Q1G3 Aytl1 Aytl1a ENSMUST00000046290.1 ENSMUST00000046290.2 Lpcat2a NM_173014 PCAT2_MOUSE Q8BYI6 uc009mug.1 uc009mug.2 uc009mug.3 Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:18156367, PubMed:18285344). Activity is calcium-dependent (PubMed:17182612). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3- phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero- 3-phosphocholine or PC) (PubMed:17182612, PubMed:18156367). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O- alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl- sn-glycero-3-phosphocholine (PAF) (PubMed:17182612, PubMed:18285344). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (PubMed:17182612). Under resting conditions, acyltransferase activity is preferred (PubMed:17182612). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (PubMed:17182612). Involved in the regulation of lipid droplet number and size (By similarity). Reaction=a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2- diacyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:12937, ChEBI:CHEBI:57287, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:58342; EC=2.3.1.23; Evidence=; Reaction=1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O- alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:18461, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.67; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:10344, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:77286, ChEBI:CHEBI:77287; EC=2.3.1.25; Evidence=; Reaction=1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O- octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37699, ChEBI:CHEBI:52450, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:75216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37700; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1- hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37703, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:72998, ChEBI:CHEBI:75219; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37704; Evidence=; Reaction=1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1- octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37707, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:73858, ChEBI:CHEBI:75220; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37708; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA = 1- O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37711, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:77287, ChEBI:CHEBI:78566; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37712; Evidence=; Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O- hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37719, ChEBI:CHEBI:44811, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37720; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn- glycero-3-phosphocholine = 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37747, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:75216, ChEBI:CHEBI:75245; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37748; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:33187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57518, ChEBI:CHEBI:64839; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33188; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74544, ChEBI:CHEBI:74546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37132; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37143, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74544, ChEBI:CHEBI:74551; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37144; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37151, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74554, ChEBI:CHEBI:74556; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37152; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37163, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74560, ChEBI:CHEBI:74565; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37164; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37155, ChEBI:CHEBI:57287, ChEBI:CHEBI:74307, ChEBI:CHEBI:74544, ChEBI:CHEBI:74558; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37156; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero- 3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn- glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37159, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74544, ChEBI:CHEBI:74563; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37160; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37171, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:74544, ChEBI:CHEBI:74579; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37172; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37175, ChEBI:CHEBI:57287, ChEBI:CHEBI:74309, ChEBI:CHEBI:74544, ChEBI:CHEBI:74578; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37176; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37595, ChEBI:CHEBI:57287, ChEBI:CHEBI:74544, ChEBI:CHEBI:75104, ChEBI:CHEBI:75105; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37596; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:35991, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35992; Evidence=; Acetyltransferase activity is increased following acute inflammatory stimulation by lipopolysaccharide (LPS). Acyltransferase activity is unchanged. Kinetic parameters: KM=50.4 uM for acetyl-CoA ; KM=21.1 uM for arachidonoyl-CoA ; Temperature dependence: Optimum temperature is 7.4 degrees Celsius. ; Lipid metabolism; phospholipid metabolism. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Golgi apparatus membrane ; Single-pass type II membrane protein Cell membrane ; Single-pass type II membrane protein Lipid droplet Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=a, Aytl1_v1; IsoId=Q8BYI6-1; Sequence=Displayed; Name=2; Synonyms=b, Aytl1_v2; IsoId=Q8BYI6-2; Sequence=VSP_037079; Name=3; Synonyms=c, Aytl1_v3; IsoId=Q8BYI6-3; Sequence=VSP_037080, VSP_037081; Highest expression is found in resident macrophages and casein-induced neutrophils followed by skin, colon, spleen and thioglycollate-induced macrophages. Detected in erythroleukemic cells but not in reticulocytes. By inflammatory stimulation by LPS and by ODN1826, a TLR9 ligand, but not by poly(I:C), a TLR3 ligand. The HXXXXD motif is essential for acyltransferase activity. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. Golgi membrane 1-acylglycerol-3-phosphate O-acyltransferase activity calcium ion binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus Golgi stack lipid particle lipid metabolic process phospholipid metabolic process platelet activating factor biosynthetic process phospholipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups phosphatidylcholine acyl-chain remodeling metal ion binding 1-acylglycerophosphocholine O-acyltransferase activity 1-alkylglycerophosphocholine O-acetyltransferase activity membrane organization uc009mug.1 uc009mug.2 uc009mug.3 
ENSMUST00000046303.12 Crebl2 ENSMUST00000046303.12 cAMP responsive element binding protein-like 2 (from RefSeq NM_177687.3) A0A0R4J0D8 A0A0R4J0D8_MOUSE Crebl2 ENSMUST00000046303.1 ENSMUST00000046303.10 ENSMUST00000046303.11 ENSMUST00000046303.2 ENSMUST00000046303.3 ENSMUST00000046303.4 ENSMUST00000046303.5 ENSMUST00000046303.6 ENSMUST00000046303.7 ENSMUST00000046303.8 ENSMUST00000046303.9 NM_177687 uc009ekt.1 uc009ekt.2 uc009ekt.3 Nucleus Belongs to the bZIP family. ATF subfamily. transcription factor activity, sequence-specific DNA binding regulation of transcription, DNA-templated uc009ekt.1 uc009ekt.2 uc009ekt.3 
ENSMUST00000046305.12 Arid4a ENSMUST00000046305.12 AT-rich interaction domain 4A (from RefSeq NM_001081195.1) ARI4A_MOUSE Arid4a B2RXT8 B2RY61 ENSMUST00000046305.1 ENSMUST00000046305.10 ENSMUST00000046305.11 ENSMUST00000046305.2 ENSMUST00000046305.3 ENSMUST00000046305.4 ENSMUST00000046305.5 ENSMUST00000046305.6 ENSMUST00000046305.7 ENSMUST00000046305.8 ENSMUST00000046305.9 F8VPQ2 NM_001081195 Q05CI2 Q6PE90 Rbbp1 Rbp1 uc007nud.1 uc007nud.2 uc007nud.3 DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (PubMed:17043311, PubMed:23487765). May function as part of an mSin3A repressor complex (By similarity). Has no intrinsic transcriptional activity (PubMed:23487765). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (PubMed:17043311). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation (PubMed:23487765). Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (PubMed:23487765). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis (PubMed:18728284). May function as a leukemia suppressor (PubMed:18728284). Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, BRMS1, HDAC1 and HDAC2 (By similarity). Interacts with BRMS1 (By similarity). Interacts with RB1 (By similarity). Interacts with ARID4B (PubMed:17043311). Interacts with AR (PubMed:23487765). Nucleus Expressed in Sertoli cells of the testis. The function of the Tudor-knot domain, also named chromodomain- like, is uncertain. One study suggests that it mediates binding to lysine-methylated histone tails, with strongest affinity for H4K20me3 and H3K36me3. However, another study failed to find any interaction between this domain and histone H4K20me3 peptide. Viable and fertile, although females have reduced fertility (PubMed:17043311, PubMed:18728284). At two months of age, animals show abnormal blood cell production accompanied by mild anemia, leukopenia and thrombocytopenia. Hematologic abnormalities become progressively more severe with age (PubMed:18728284). Monocytosis is observed at 5 months onwards, along with splenomegaly and hepatomegaly (PubMed:18728284). Approximately 12% of animals develop acute myeloid leukemia (AML) and/or myeloid sarcoma (PubMed:18728284). Mortality increases rapidly from age 6 months onwards, with no survival past 22 months (PubMed:18728284). Expansion of hematopoietic stem cell and common myeloid progenitor cell populations, and their downstream lineage, is observed in bone marrow and spleen; the effect is most significant in spleen (PubMed:18728284). Bone marrow cells show altered patterns of histone methylation and significantly increased levels of both H3K4me3 and H3K9me3 (PubMed:18728284). Expression of HOXB3, HOXB5, HOXB6, HOXB8 and PITX2 in bone marrow cells is reduced (PubMed:18728284). No effect on histone methylation at the PWS/AS imprinting center (PubMed:17043311). Double knockouts with ARID4B heterozygotes show a more severe hematologic phenotype with 83% of animals progressing to AML, and with earlier age of onset (PubMed:18728284). In bone marrow cells, expression of FOXP3 is significantly reduced (PubMed:18728284). Males show progressive reduction in fertility from 2 months of age onwards, with reduced testis size and variable defects in seminal vesicle formation (PubMed:23487765). Spermatogenesis is partially blocked from the meiois II stage onwards leading to reduced numbers of mature spermatozoa (PubMed:23487765). Expression in testis of CLDN3, an androgen receptor- regulated gene, is significantly reduced (PubMed:23487765). Expression of PTGDS is also reduced, whereas expression of INHA and EMB is moderately increased (PubMed:23487765). Maternal-specific trimethylation of H4K20 and H3K9 at the PWS/AS imprinting center is significantly reduced (PubMed:17043311). DNA binding nucleus nucleoplasm cytosol plasma membrane chromatin organization regulation of gene expression by genetic imprinting regulation of transcription from RNA polymerase II promoter spermatogenesis transcriptional repressor complex cell differentiation histone H4-K20 trimethylation histone H3-K9 trimethylation transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter erythrocyte development histone H3-K4 trimethylation establishment of Sertoli cell barrier uc007nud.1 uc007nud.2 uc007nud.3 
ENSMUST00000046306.15 Ikzf5 ENSMUST00000046306.15 IKAROS family zinc finger 5, transcript variant 1 (from RefSeq NM_175115.5) ENSMUST00000046306.1 ENSMUST00000046306.10 ENSMUST00000046306.11 ENSMUST00000046306.12 ENSMUST00000046306.13 ENSMUST00000046306.14 ENSMUST00000046306.2 ENSMUST00000046306.3 ENSMUST00000046306.4 ENSMUST00000046306.5 ENSMUST00000046306.6 ENSMUST00000046306.7 ENSMUST00000046306.8 ENSMUST00000046306.9 IKZF5_MOUSE NM_175115 Q3U549 Q3USG0 Q8BU00 Q8BZR5 Zfpn1a5 Znfn1a5 uc009kbj.1 uc009kbj.2 uc009kbj.3 Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (By similarity). Involved in megakaryocyte differentiation (By similarity). Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 and IKZF4 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BU00-1; Sequence=Displayed; Name=2; IsoId=Q8BU00-2; Sequence=VSP_027692, VSP_027693; Name=3; IsoId=Q8BU00-3; Sequence=VSP_027694; The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members. C-terminal zinc fingers mediate homodimerization. 'Pegasus' was the winged horse in Greek mythology. Belongs to the Ikaros C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm zinc ion binding protein domain specific binding macromolecular complex transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding protein heterooligomerization uc009kbj.1 uc009kbj.2 uc009kbj.3 
ENSMUST00000046316.11 Lrig2 ENSMUST00000046316.11 leucine-rich repeats and immunoglobulin-like domains 2, transcript variant 1 (from RefSeq NM_001025067.2) ENSMUST00000046316.1 ENSMUST00000046316.10 ENSMUST00000046316.2 ENSMUST00000046316.3 ENSMUST00000046316.4 ENSMUST00000046316.5 ENSMUST00000046316.6 ENSMUST00000046316.7 ENSMUST00000046316.8 ENSMUST00000046316.9 Kiaa0806 LRIG2_MOUSE NM_001025067 Q52KR2 Q69ZY8 uc008que.1 uc008que.2 uc008que.3 uc008que.4 Cell membrane ; Single-pass type I membrane protein Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q52KR2-1; Sequence=Displayed; Name=2; IsoId=Q52KR2-2; Sequence=VSP_014993, VSP_057113; [Isoform 2]: May be due to a competing acceptor splice site. Sequence=BAD32308.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; receptor binding protein binding extracellular space cytoplasm plasma membrane sensory perception of sound regulation of platelet-derived growth factor receptor signaling pathway negative regulation of neuron projection development membrane integral component of membrane growth cone extracellular matrix neuron projection neuronal cell body regulation of axon regeneration negative regulation of axon regeneration negative regulation of membrane protein ectodomain proteolysis innervation intracellular vesicle positive regulation of protein localization to cell surface regulation of neuron migration uc008que.1 uc008que.2 uc008que.3 uc008que.4 
ENSMUST00000046331.5 Wdr20rt ENSMUST00000046331.5 WD repeat domain 20, retrogene (from RefSeq NM_027614.1) ENSMUST00000046331.1 ENSMUST00000046331.2 ENSMUST00000046331.3 ENSMUST00000046331.4 NM_027614 Q80X67 Q9D5L0 Q9D5R2 WDR20_MOUSE Wdr20 Wdr20b uc007nrk.1 uc007nrk.2 Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme. Regulates shuttling of complexes containing USP12 between the plasma membrane, cytoplasm and nucleus. Interacts with USP12; promotes translocation of USP12/WDR20 to the plasma membrane. Component of the USP12/WDR20/WDR48 deubiquitinating complex. Interacts with USP46; contributes to the cytoplasmic localization of the USP46/WDR20 complex. Component of the USP12/DMWD/WDR48 deubiquitinating complex. Cytoplasm Nucleus molecular_function cellular_component uc007nrk.1 uc007nrk.2 
ENSMUST00000046332.6 C1qc ENSMUST00000046332.6 complement component 1, q subcomponent, C chain, transcript variant 1 (from RefSeq NM_007574.3) C1QC_MOUSE C1qg ENSMUST00000046332.1 ENSMUST00000046332.2 ENSMUST00000046332.3 ENSMUST00000046332.4 ENSMUST00000046332.5 NM_007574 Q02105 Q6DI63 uc008viq.1 uc008viq.2 uc008viq.3 C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain. Antigen-bound IgM (via the Fc region) interacts with the globular domains of C1q component of the complement system, all three modules C1QA, C1QB and C1QC being involved in IgM binding; this interaction is multivalent. It initiates the classical complement pathway. Secreted. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4- hydroxylation in vertebrates. immune system process extracellular region collagen trimer extracellular space cell complement activation, classical pathway negative regulation of granulocyte differentiation innate immune response synapse negative regulation of macrophage differentiation postsynapse synapse disassembly uc008viq.1 uc008viq.2 uc008viq.3 
ENSMUST00000046333.9 Tmem225 ENSMUST00000046333.9 transmembrane protein 225, transcript variant 1 (from RefSeq NM_029379.1) ENSMUST00000046333.1 ENSMUST00000046333.2 ENSMUST00000046333.3 ENSMUST00000046333.4 ENSMUST00000046333.5 ENSMUST00000046333.6 ENSMUST00000046333.7 ENSMUST00000046333.8 NM_029379 Pmp22cd Q9D9S2 TM225_MOUSE uc009oze.1 uc009oze.2 uc009oze.3 uc009oze.4 uc009oze.5 Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC. Interacts (via RVxF motif) with PPP1CC. Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Multi-pass membrane protein Expressed in testis, epididymis and spermatozoa (at protein level). Not expressed in brain, heart, lung, liver, spleen, kidney and skeletal muscle. Detected in testis 25 days after birth and thereafter. This protein is not related to the claudin family. acrosomal membrane molecular_function cellular_component negative regulation of phosphatase activity membrane integral component of membrane cytoplasmic vesicle uc009oze.1 uc009oze.2 uc009oze.3 uc009oze.4 uc009oze.5 
ENSMUST00000046351.7 Lrfn3 ENSMUST00000046351.7 leucine rich repeat and fibronectin type III domain containing 3 (from RefSeq NM_175478.2) ENSMUST00000046351.1 ENSMUST00000046351.2 ENSMUST00000046351.3 ENSMUST00000046351.4 ENSMUST00000046351.5 ENSMUST00000046351.6 LRFN3_MOUSE NM_175478 Q505E2 Q8BLY3 Salm4 uc009gee.1 uc009gee.2 uc009gee.3 Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons. Can form heteromeric complexes with LRFN1, LRFN2, LRFN4 and LRFN5. Able to form homomeric complexes across cell junctions, between adjacent cells. Does not interact with DLG4. Cell membrane ; Single-pass type I membrane protein Cell projection, axon Cell projection, dendrite Synapse Presynaptic cell membrane Postsynaptic cell membrane Expressed in brain, testis, stomach, small intestine and kidney. Residually expressed in heart, lung, liver, skeletal muscle and uterus. In the brain, weak, but broad expression in the cerebral cortex and diencephalic nuclei. Also detected in other parts of the central nervous system, including the olfactory bulb, pons, cerebellum, and medulla oblongata, as well as in the peripheral nervous system, such as the ganglia of cranial nerves and the dorsal root ganglion during gestation. Expressed from 4.5 to 18.5 dpc. Initial levels are low until 6.5 dpc and residual from 7.5 to 9.5 dpc. Expression increases from 10.5 to 15.5 dpc before falling again to a level slightly higher than the one seen on 4.5 to 6.5 dpc. At 11.5 dpc, broadly expressed in the telencephalic and diencephalic vesicles. At 17.5 dpc, expressed in cerebral cortex, hippocampus, dorsal thalamus and amygdala. Lacks a cytoplasmic PDZ-binding domain, which has been implicated in function of related Lrfn proteins. N-glycosylated. Belongs to the LRFN family. plasma membrane cell adhesion cell surface membrane integral component of membrane cell junction axon dendrite presynaptic membrane cell projection synapse postsynaptic membrane glutamatergic synapse integral component of presynaptic active zone membrane integral component of postsynaptic specialization membrane integral component of postsynaptic density membrane synaptic membrane adhesion regulation of presynapse assembly uc009gee.1 uc009gee.2 uc009gee.3 
ENSMUST00000046371.13 Plppr2 ENSMUST00000046371.13 phospholipid phosphatase related 2, transcript variant 2 (from RefSeq NM_001290299.1) ENSMUST00000046371.1 ENSMUST00000046371.10 ENSMUST00000046371.11 ENSMUST00000046371.12 ENSMUST00000046371.2 ENSMUST00000046371.3 ENSMUST00000046371.4 ENSMUST00000046371.5 ENSMUST00000046371.6 ENSMUST00000046371.7 ENSMUST00000046371.8 ENSMUST00000046371.9 Lppr2 NM_001290299 PLPR2_MOUSE Plppr2 Prg4 Q8BIE4 Q8VCY8 uc009ona.1 uc009ona.2 uc009ona.3 uc009ona.4 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VCY8-1; Sequence=Displayed; Name=2; IsoId=Q8VCY8-2; Sequence=VSP_031012; Belongs to the PA-phosphatase related phosphoesterase family. Has most probably no phospholipid phosphatase activity (By similarity). This is supported by the fact that the phosphatase sequence motifs as well as the His residue acting as a nucleophile in active phosphatases of the PA-phosphatase related phosphoesterase family are not conserved (By similarity). integral component of plasma membrane phospholipid metabolic process phosphatidate phosphatase activity membrane integral component of membrane hydrolase activity phosphatase activity lipid phosphatase activity phospholipid dephosphorylation uc009ona.1 uc009ona.2 uc009ona.3 uc009ona.4 
ENSMUST00000046373.8 Iqsec3 ENSMUST00000046373.8 IQ motif and Sec7 domain 3, transcript variant 6 (from RefSeq NR_177449.1) ENSMUST00000046373.1 ENSMUST00000046373.2 ENSMUST00000046373.3 ENSMUST00000046373.4 ENSMUST00000046373.5 ENSMUST00000046373.6 ENSMUST00000046373.7 IQEC3_MOUSE Kiaa1110 NR_177449 Q3TES0 Q3UHP8 Q80TJ8 uc009dom.1 uc009dom.2 uc009dom.3 uc009dom.4 uc009dom.5 Acts as a guanine nucleotide exchange factor (GEF) for ARF1. Interacts with DLG1 and DLG4 (By similarity). Interacts with GPHN (PubMed:27609886). Cytoplasm Postsynaptic density Expressed specifically in the adult brain, but not in the fetal brain at 14 dpc. Belongs to the BRAG family. ARF guanyl-nucleotide exchange factor activity protein binding cytoplasm plasma membrane postsynaptic density membrane actin cytoskeleton organization cell junction regulation of ARF protein signal transduction synapse postsynaptic membrane synapse organization regulation of small GTPase mediated signal transduction inhibitory synapse activation of GTPase activity GABA-ergic synapse postsynaptic specialization of symmetric synapse uc009dom.1 uc009dom.2 uc009dom.3 uc009dom.4 uc009dom.5 
ENSMUST00000046383.12 Tnfsf10 ENSMUST00000046383.12 tumor necrosis factor (ligand) superfamily, member 10 (from RefSeq NM_009425.2) ENSMUST00000046383.1 ENSMUST00000046383.10 ENSMUST00000046383.11 ENSMUST00000046383.2 ENSMUST00000046383.3 ENSMUST00000046383.4 ENSMUST00000046383.5 ENSMUST00000046383.6 ENSMUST00000046383.7 ENSMUST00000046383.8 ENSMUST00000046383.9 NM_009425 Q3U5H0 Q3U5H0_MOUSE Tnfsf10 uc008otm.1 uc008otm.2 uc008otm.3 Homotrimer. Membrane ; Single- pass type II membrane protein Belongs to the tumor necrosis factor family. cytokine activity tumor necrosis factor receptor binding extracellular space immune response signal transduction zinc ion binding male gonad development membrane integral component of membrane response to insulin identical protein binding positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process metal ion binding positive regulation of release of cytochrome c from mitochondria positive regulation of extrinsic apoptotic signaling pathway uc008otm.1 uc008otm.2 uc008otm.3 
ENSMUST00000046384.9 C1qb ENSMUST00000046384.9 complement component 1, q subcomponent, beta polypeptide (from RefSeq NM_009777.3) C1QB_MOUSE ENSMUST00000046384.1 ENSMUST00000046384.2 ENSMUST00000046384.3 ENSMUST00000046384.4 ENSMUST00000046384.5 ENSMUST00000046384.6 ENSMUST00000046384.7 ENSMUST00000046384.8 NM_009777 P14106 Q3U793 uc008vip.1 uc008vip.2 uc008vip.3 uc008vip.4 C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. C1 is a calcium-dependent trimolecular complex of C1q, c1r and C1s in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain. Antigen-bound IgM (via the Fc region) interacts with the globular domains of C1q component of the complement system, all three modules C1QA, C1QB and C1QC being involved in IgM binding; this interaction is multivalent. It initiates the classical complement pathway. Secreted. Highest expression in thioglycolate-activated peritoneal macrophages. Also found in spleen, thymus and heart. Very weak expression liver, kidney, lung and intestine. Hydroxylated on lysine and proline residues. Hydroxylated lysine residues can be glycosylated. Mouse C1Q contains up to 64.0 hydroxylysine-galactosylglucose residues. Total percentage hydroxylysine residues glycosylated is 95.1%. Contains no hydroxylysine-monosaccharides. immune system process extracellular region collagen trimer complement component C1 complex extracellular space cell complement activation, classical pathway protein homodimerization activity innate immune response synapse inner ear development postsynapse synapse disassembly uc008vip.1 uc008vip.2 uc008vip.3 uc008vip.4 
ENSMUST00000046386.5 Zcchc14 ENSMUST00000046386.5 zinc finger, CCHC domain containing 14, transcript variant 1 (from RefSeq NM_080855.3) A0A9S4GT61 A0A9S4GT61_MOUSE ENSMUST00000046386.1 ENSMUST00000046386.2 ENSMUST00000046386.3 ENSMUST00000046386.4 NM_080855 Zcchc14 uc009nrx.1 uc009nrx.2 uc009nrx.3 uc009nrx.4 uc009nrx.1 uc009nrx.2 uc009nrx.3 uc009nrx.4 
ENSMUST00000046389.5 Rbm45 ENSMUST00000046389.5 RNA binding motif protein 45 (from RefSeq NM_153405.2) Drb1 Drbp1 ENSMUST00000046389.1 ENSMUST00000046389.2 ENSMUST00000046389.3 ENSMUST00000046389.4 NM_153405 Q8BHN5 Q8C1Z5 RBM45_MOUSE uc008kez.1 uc008kez.2 uc008kez.3 RNA-binding protein with binding specificity for poly(C). May play an important role in neural development (By similarity). Cytoplasm Nucleus Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus. Sequence=BAC41024.1; Type=Frameshift; Evidence=; nucleic acid binding RNA binding mRNA binding nucleus cytoplasm multicellular organism development nervous system development biological_process cell differentiation ribonucleoprotein complex uc008kez.1 uc008kez.2 uc008kez.3 
ENSMUST00000046399.7 Apmap ENSMUST00000046399.7 adipocyte plasma membrane associated protein, transcript variant 1 (from RefSeq NM_027977.3) A2AQX3 APMAP_MOUSE ENSMUST00000046399.1 ENSMUST00000046399.2 ENSMUST00000046399.3 ENSMUST00000046399.4 ENSMUST00000046399.5 ENSMUST00000046399.6 NM_027977 Q3U4F4 Q9D7N9 uc008mud.1 uc008mud.2 uc008mud.3 Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate (By similarity). May play a role in adipocyte differentiation. Membrane ; Single-pass type II membrane protein Strongly expressed in adipose tissue. Highly expressed in liver, heart, and kidney. Expressed at intermediate level in brain and lung. Weakly expressed in spleen, skeletal muscle and testis. Expressed during adipocyte differentiation. Expression appears 3 days following induction of adipose conversion. Glycosylated in vitro. Belongs to the strictosidine synthase family. arylesterase activity endoplasmic reticulum biosynthetic process cell surface membrane integral component of membrane strictosidine synthase activity uc008mud.1 uc008mud.2 uc008mud.3 
ENSMUST00000046404.8 Ubr7 ENSMUST00000046404.8 ubiquitin protein ligase E3 component n-recognin 7 (putative) (from RefSeq NM_025666.2) ENSMUST00000046404.1 ENSMUST00000046404.2 ENSMUST00000046404.3 ENSMUST00000046404.4 ENSMUST00000046404.5 ENSMUST00000046404.6 ENSMUST00000046404.7 NM_025666 Q80UT9 Q8BU04 UBR7_MOUSE uc007oup.1 uc007oup.2 uc007oup.3 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Expressed in testis and sperm (at protein level). cytoplasm biological_process zinc ion binding protein ubiquitination transferase activity metal ion binding ubiquitin protein ligase activity uc007oup.1 uc007oup.2 uc007oup.3 
ENSMUST00000046418.3 Ints15 ENSMUST00000046418.3 integrator complex subunit 15 (from RefSeq NM_172726.4) ENSMUST00000046418.1 ENSMUST00000046418.2 INT15_MOUSE Ints15 NM_172726 Q3T9D0 Q8BGA7 Q8BN55 uc009ajy.1 uc009ajy.2 uc009ajy.3 uc009ajy.4 Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. Probable component of the multiprotein Integrator (INT) complex. Nucleus molecular_function cellular_component biological_process uc009ajy.1 uc009ajy.2 uc009ajy.3 uc009ajy.4 
ENSMUST00000046422.11 Acot5 ENSMUST00000046422.11 acyl-CoA thioesterase 5, transcript variant 1 (from RefSeq NM_145444.3) ACOT5_MOUSE E9QKJ5 ENSMUST00000046422.1 ENSMUST00000046422.10 ENSMUST00000046422.2 ENSMUST00000046422.3 ENSMUST00000046422.4 ENSMUST00000046422.5 ENSMUST00000046422.6 ENSMUST00000046422.7 ENSMUST00000046422.8 ENSMUST00000046422.9 NM_145444 Q6Q2Z6 uc007oeh.1 uc007oeh.2 Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16940157). Mainly active on medium-chain acyl-CoAs (PubMed:15007068). Seems to be involved in intraperoxisomal regulation of acyl-CoA levels, but not CoASH levels (PubMed:15007068). May have a function in termination of beta-oxidation of fatty acids (PubMed:15007068). Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence=; Reaction=decanoyl-CoA + H2O = CoA + decanoate + H(+); Xref=Rhea:RHEA:40059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40060; Evidence=; Reaction=H2O + octanoyl-CoA = CoA + H(+) + octanoate; Xref=Rhea:RHEA:30143, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30144; Evidence=; Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence=; Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=; Reaction=H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate; Xref=Rhea:RHEA:30139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30140; Evidence=; Reaction=eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+); Xref=Rhea:RHEA:40147, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32360, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40148; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40140; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+); Xref=Rhea:RHEA:40143, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40144; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)- eicosatetraenoate + CoA + H(+); Xref=Rhea:RHEA:40151, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40152; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+); Xref=Rhea:RHEA:40131, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40132; Evidence=; Kinetic parameters: KM=28.4 uM for hexanoyl-coA ; KM=7.7 uM for octanoyl-coA ; KM=18 uM for decanoyl-coA ; KM=7.6 uM for dodecanoyl-coA ; KM=5.6 uM for tetradecanoyl-coA ; KM=15.9 uM for hexadecanoyl-coA ; KM=7.0 uM for (9Z)-hexadecenoyl-coA ; KM=34.8 uM for octadecanoyl-coA ; KM=8.9 uM for (9Z)-octadecenoyl-coA ; KM=32.5 uM for (9Z,12Z)-octadecadienoyl-coA ; KM=32.7 uM for eicosanoyl-coA ; KM=1.6 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoyl-coA ; Vmax=0.23 umol/min/mg enzyme with hexanoyl-coA as substrate ; Vmax=0.74 umol/min/mg enzyme with octanoyl-coA as substrate ; Vmax=1.20 umol/min/mg enzyme with decanoyl-coA as substrate ; Vmax=1.10 umol/min/mg enzyme with dodecanoyl-coA as substrate ; Vmax=0.83 umol/min/mg enzyme with tetradecanoyl-coA as substrate ; Vmax=0.49 umol/min/mg enzyme with hexadecanoyl-coA as substrate ; Vmax=0.32 umol/min/mg enzyme with (9Z)-hexadecenoyl-coA as substrate ; Vmax=0.38 umol/min/mg enzyme with octadecanoyl-coA as substrate ; Vmax=0.14 umol/min/mg enzyme with (9Z)-octadecenoyl-coA as substrate ; Vmax=0.17 umol/min/mg enzyme with (9Z,12Z)-octadecadienoyl-coA as substrate ; Vmax=0.18 umol/min/mg enzyme with eicosanoyl-coA as substrate ; Vmax=0.23 umol/min/mg enzyme with (5Z,8Z,11Z,14Z)-eicosatetraenoyl- coA as substrate ; Lipid metabolism; fatty acid metabolism. Peroxisome Highly expressed in spleen, brain, testis and proximal and distal intestine; expressed at low level in the liver. In the liver and kidney, by peroxisome proliferator, via the peroxisome proliferator-activated receptors (PPARs) and by fasting. Belongs to the C/M/P thioester hydrolase family. very long-chain fatty acid metabolic process long-chain fatty acid metabolic process peroxisome cytosol lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process palmitoyl-CoA hydrolase activity hydrolase activity thiolester hydrolase activity saturated monocarboxylic acid metabolic process unsaturated monocarboxylic acid metabolic process acyl-CoA hydrolase activity carboxylic ester hydrolase activity uc007oeh.1 uc007oeh.2 
ENSMUST00000046425.16 Txlna ENSMUST00000046425.16 taxilin alpha, transcript variant 2 (from RefSeq NM_001199695.1) ENSMUST00000046425.1 ENSMUST00000046425.10 ENSMUST00000046425.11 ENSMUST00000046425.12 ENSMUST00000046425.13 ENSMUST00000046425.14 ENSMUST00000046425.15 ENSMUST00000046425.2 ENSMUST00000046425.3 ENSMUST00000046425.4 ENSMUST00000046425.5 ENSMUST00000046425.6 ENSMUST00000046425.7 ENSMUST00000046425.8 ENSMUST00000046425.9 NM_001199695 Q6P1E5 Q6PAM1 TXLNA_MOUSE Txln uc008uxy.1 uc008uxy.2 uc008uxy.3 uc008uxy.4 May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PAM1-1; Sequence=Displayed; Name=2; IsoId=Q6PAM1-2; Sequence=VSP_011833, VSP_011834; Belongs to the taxilin family. cytoplasm exocytosis syntaxin binding B cell activation uc008uxy.1 uc008uxy.2 uc008uxy.3 uc008uxy.4 
ENSMUST00000046426.10 Tpcn1 ENSMUST00000046426.10 two pore channel 1, transcript variant 8 (from RefSeq NR_184702.1) ENSMUST00000046426.1 ENSMUST00000046426.2 ENSMUST00000046426.3 ENSMUST00000046426.4 ENSMUST00000046426.5 ENSMUST00000046426.6 ENSMUST00000046426.7 ENSMUST00000046426.8 ENSMUST00000046426.9 Kiaa1169 NR_184702 Q3V2Z6 Q6ZPW5 Q9EQJ0 TPC1_MOUSE Tpc1 Tpcn1 uc008zhm.1 uc008zhm.2 uc008zhm.3 Intracellular channel initially characterized as a non- selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly- selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles (PubMed:24776928, PubMed:23394946, PubMed:23063126). Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (PubMed:28855648). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (By similarity). Required for mTOR-dependent nutrient sensing (PubMed:23394946). Reaction=Na(+)(in) = Na(+)(out); Xref=Rhea:RHEA:34963, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:34965; Evidence=; Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671, ChEBI:CHEBI:29108; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29673; Evidence=; Na(+) current is inhibited by ATP in a MTORC- dependent manner. ATP sensitivity is independent of PI(3,5)P2 (By similarity). Probably regulated by Mg(2+) ions, cytosolic Mg(2+) selectively inhibits outward current while lysosomal Mg(2+) modestly inhibits both the outward and inward currents. In the absence of Mg(2+), NAADP readily activates TPCN2, with properties similar to PI(3,5)P2 (By similarity). Both current elicited by PI(3,5)P2 as well as NAADP are inhibited by tetrandrine (By similarity). Dimer. Interacts with MTOR; the interaction is required for TPCN1 ATP sensitivity (By similarity). Interacts with STX7, STX8 and STX12 (PubMed:28855648). Interacts with JPT2 (By similarity). Found in a complex with LSM12, TPCN1 and TPCN2 (By similarity). Lysosome membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EQJ0-1; Sequence=Displayed; Name=2; IsoId=Q9EQJ0-2; Sequence=VSP_023006, VSP_023007; Mainly expressed in epithelial tissues like lung, kidney, colon, spleen and liver (at protein level). Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. N-glycosylated. TPCN1 and TPCN2 double knockouts are viable, fertile, have no obvious morphological abnormalities, and no obvious behavioral defects. After fasting for 3 days, they are less active and endurance performance is reduced by 8.3 fold in contrast to wild-type littermates that show no changes. Two days after re-introduction of food, mutants regain endurance and become as active as before fasting. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. ion channel activity voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated sodium channel activity calcium channel activity lysosome lysosomal membrane endosome ion transport calcium ion transport endosome membrane positive regulation of autophagy ligand-gated sodium channel activity membrane integral component of membrane regulation of ion transmembrane transport sodium ion transmembrane transport identical protein binding protein homodimerization activity release of sequestered calcium ion into cytosol transmembrane transport calcium ion transmembrane transport NAADP-sensitive calcium-release channel activity phosphatidylinositol-3,5-bisphosphate binding uc008zhm.1 uc008zhm.2 uc008zhm.3 
ENSMUST00000046433.7 Rnf113a1 ENSMUST00000046433.7 ring finger protein 113A1 (from RefSeq NM_153503.2) ENSMUST00000046433.1 ENSMUST00000046433.2 ENSMUST00000046433.3 ENSMUST00000046433.4 ENSMUST00000046433.5 ENSMUST00000046433.6 NM_153503 Q8R3P8 Q8R3P8_MOUSE Rnf113a1 uc009syj.1 uc009syj.2 uc009syj.3 uc009syj.4 uc009syj.5 molecular_function U2-type spliceosomal complex snoRNA splicing metal ion binding uc009syj.1 uc009syj.2 uc009syj.3 uc009syj.4 uc009syj.5 
ENSMUST00000046461.9 Dok4 ENSMUST00000046461.9 docking protein 4 (from RefSeq NM_053246.3) DOK4_MOUSE ENSMUST00000046461.1 ENSMUST00000046461.2 ENSMUST00000046461.3 ENSMUST00000046461.4 ENSMUST00000046461.5 ENSMUST00000046461.6 ENSMUST00000046461.7 ENSMUST00000046461.8 NM_053246 Q3U0X3 Q99KE3 uc009mxg.1 uc009mxg.2 uc009mxg.3 uc009mxg.4 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity). Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062'. Widely expressed. Highest levels in heart, lung and kidney. At 12.5 dpc and 13.5 dpc, expressed in the central and peripheral nervous system and in endothelia. In the nervous system, expression localized to the ventral portion of the neural tube and the dorsal root and cranial sensory ganglia. Expression confined to neurons. PTB domain mediates receptor interaction. Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation. Belongs to the DOK family. Type B subfamily. protein binding transmembrane receptor protein tyrosine kinase signaling pathway nervous system development positive regulation of MAPK cascade uc009mxg.1 uc009mxg.2 uc009mxg.3 uc009mxg.4 
ENSMUST00000046463.10 Gtpbp1 ENSMUST00000046463.10 GTP binding protein 1 (from RefSeq NM_013818.2) ENSMUST00000046463.1 ENSMUST00000046463.2 ENSMUST00000046463.3 ENSMUST00000046463.4 ENSMUST00000046463.5 ENSMUST00000046463.6 ENSMUST00000046463.7 ENSMUST00000046463.8 ENSMUST00000046463.9 GTPB1_MOUSE Gtpbp NM_013818 O08582 Q3UD96 Q3UGW6 Q545R1 Q80ZY5 uc007wuf.1 uc007wuf.2 uc007wuf.3 Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). Interacts with EXOSC2/RRP4, EXOSC3/RRP40, EXOSC5/RRP46, HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with AANAT mRNA, but does not bind mRNA by itself (By similarity). Cytoplasm Detected in some neurons in the brain cortex. Detected in small arteries, dendritic cells and macrophages in the thymus. Detected in lung bronchi, in bronchial epithelial cells and in bronchial smooth muscle cells. Detected in smooth muscle cells in a broad range of organs (at protein level). Expressed in brain, thymus, lung, and kidney. No visible phenotype. Mice are born at the expected Mendelian ratio, develop normally and are fertile. They exhibit increased stability of some mRNA species. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily. Sequence=AAB51274.1; Type=Erroneous initiation; Evidence=; Sequence=BAB23409.1; Type=Erroneous initiation; Evidence=; Sequence=BAE28091.1; Type=Frameshift; Evidence=; Sequence=BAE29280.1; Type=Frameshift; Evidence=; Sequence=BAE29365.1; Type=Frameshift; Evidence=; nucleotide binding cytoplasmic exosome (RNase complex) translation elongation factor activity GTPase activity GTP binding cytoplasm cytosol translational elongation GTP metabolic process positive regulation of mRNA catabolic process uc007wuf.1 uc007wuf.2 uc007wuf.3 
ENSMUST00000046470.16 Mettl22 ENSMUST00000046470.16 methyltransferase 22, Kin17 lysine, transcript variant 9 (from RefSeq NR_184431.1) ENSMUST00000046470.1 ENSMUST00000046470.10 ENSMUST00000046470.11 ENSMUST00000046470.12 ENSMUST00000046470.13 ENSMUST00000046470.14 ENSMUST00000046470.15 ENSMUST00000046470.2 ENSMUST00000046470.3 ENSMUST00000046470.4 ENSMUST00000046470.5 ENSMUST00000046470.6 ENSMUST00000046470.7 ENSMUST00000046470.8 ENSMUST00000046470.9 MET22_MOUSE NR_184431 Q3UW48 Q8R1C6 uc007ycl.1 uc007ycl.2 uc007ycl.3 Protein N-lysine methyltransferase. Trimethylates KIN at Lys- 135 (in vitro). Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54193; Evidence=; Interacts with members of the heat shock protein 90 and 70 families; these proteins probably are methylation substrates. Nucleus Belongs to the methyltransferase superfamily. METTL22 family. Sequence=BAE23071.1; Type=Frameshift; Evidence=; nucleus nucleolus protein methylation methyltransferase activity protein methyltransferase activity transferase activity heat shock protein binding methylation macromolecular complex uc007ycl.1 uc007ycl.2 uc007ycl.3 
ENSMUST00000046485.5 Efcab11 ENSMUST00000046485.5 EF-hand calcium binding domain 11 (from RefSeq NM_030172.2) EFC11_MOUSE ENSMUST00000046485.1 ENSMUST00000046485.2 ENSMUST00000046485.3 ENSMUST00000046485.4 NM_030172 Q9D041 Q9D0E5 uc007osc.1 uc007osc.2 uc007osc.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D0E5-1; Sequence=Displayed; Name=2; IsoId=Q9D0E5-2; Sequence=VSP_025103; calcium ion binding calcium-mediated signaling metal ion binding uc007osc.1 uc007osc.2 uc007osc.3 
ENSMUST00000046497.8 Dnph1 ENSMUST00000046497.8 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (from RefSeq NM_207161.3) DNPH1_MOUSE Dnph1 ENSMUST00000046497.1 ENSMUST00000046497.2 ENSMUST00000046497.3 ENSMUST00000046497.4 ENSMUST00000046497.5 ENSMUST00000046497.6 ENSMUST00000046497.7 NM_207161 Q3U9Y7 Q80VJ3 uc008csz.1 uc008csz.2 uc008csz.3 Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration. Reaction=5-hydroxymethyl-dUMP + H2O = 2-deoxy-D-ribose 5-phosphate + 5- hydroxymethyluracil; Xref=Rhea:RHEA:77099, ChEBI:CHEBI:15377, ChEBI:CHEBI:16964, ChEBI:CHEBI:62877, ChEBI:CHEBI:90409; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77100; Evidence=; Monomer and homodimer. Cytoplasm Nucleus Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family. nucleus cytoplasm metabolic process nucleoside metabolic process nucleotide metabolic process deoxyribonucleoside monophosphate catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing N-glycosyl compounds positive regulation of cell growth epithelial cell differentiation identical protein binding protein homodimerization activity deoxyribonucleoside 5'-monophosphate N-glycosidase activity uc008csz.1 uc008csz.2 uc008csz.3 
ENSMUST00000046498.3 Gjb5 ENSMUST00000046498.3 gap junction protein, beta 5 (from RefSeq NM_010291.4) Cxna ENSMUST00000046498.1 ENSMUST00000046498.2 Gjb5 NM_010291 Q542M8 Q542M8_MOUSE uc008uuv.1 uc008uuv.2 uc008uuv.3 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Cell junction, gap junction Cell membrane ; Multi- pass membrane protein mbrane ; Multi-pass membrane protein Belongs to the connexin family. plasma membrane gap junction connexin complex cell communication membrane integral component of membrane cell junction uc008uuv.1 uc008uuv.2 uc008uuv.3 
ENSMUST00000046502.7 Rad54l2 ENSMUST00000046502.7 RAD54 like 2 (S. cerevisiae) (from RefSeq NM_030730.2) E9QKL0 E9QKL0_MOUSE ENSMUST00000046502.1 ENSMUST00000046502.2 ENSMUST00000046502.3 ENSMUST00000046502.4 ENSMUST00000046502.5 ENSMUST00000046502.6 NM_030730 Rad54l2 uc009rko.1 uc009rko.2 uc009rko.3 Nucleus ATP binding uc009rko.1 uc009rko.2 uc009rko.3 
ENSMUST00000046506.7 Clcf1 ENSMUST00000046506.7 cardiotrophin-like cytokine factor 1, transcript variant 1 (from RefSeq NM_019952.6) Bsf3 CLCF1_MOUSE ENSMUST00000046506.1 ENSMUST00000046506.2 ENSMUST00000046506.3 ENSMUST00000046506.4 ENSMUST00000046506.5 ENSMUST00000046506.6 NM_019952 Nnt1 Q3SXK2 Q9QZM3 uc008fzj.1 uc008fzj.2 uc008fzj.3 uc008fzj.4 In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (By similarity). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor (PubMed:10500198). Forms a heteromeric complex with cardiotrophin-like cytokine CRLF1/CLF-1; the CRLF1-CLCF1 complex is a ligand for the ciliary neurotrophic factor receptor/CNTFR. The CRLF1-CLCF1 heterodimer binds SORL1 (via N-terminal ectodomain); within this complex, the interaction is mediated predominantly by the CRLF1 moiety. The tripartite signaling complex formed by CRLF1, CLCF1 and CNTFR also binds SORL1. Q9QZM3; P08226: Apoe; NbExp=2; IntAct=EBI-3454258, EBI-1634131; Secreted Belongs to the IL-6 superfamily. positive regulation of immunoglobulin production positive regulation of type 2 immune response receptor binding cytokine activity ciliary neurotrophic factor receptor binding protein binding extracellular region extracellular space cell surface receptor signaling pathway JAK-STAT cascade positive regulation of cell proliferation B cell differentiation positive regulation of B cell proliferation positive regulation of tyrosine phosphorylation of STAT protein negative regulation of neuron apoptotic process protein heterodimerization activity positive regulation of isotype switching to IgE isotypes positive regulation of astrocyte differentiation regulation of inflammatory response positive regulation of corticotropin-releasing hormone secretion regulation of protein kinase B signaling regulation of ERK1 and ERK2 cascade CRLF-CLCF1 complex CNTFR-CLCF1 complex negative regulation of motor neuron apoptotic process uc008fzj.1 uc008fzj.2 uc008fzj.3 uc008fzj.4 
ENSMUST00000046513.10 Phyhipl ENSMUST00000046513.10 phytanoyl-CoA hydroxylase interacting protein-like, transcript variant 1 (from RefSeq NM_178621.4) A4FVA0 ENSMUST00000046513.1 ENSMUST00000046513.2 ENSMUST00000046513.3 ENSMUST00000046513.4 ENSMUST00000046513.5 ENSMUST00000046513.6 ENSMUST00000046513.7 ENSMUST00000046513.8 ENSMUST00000046513.9 NM_178621 PHIPL_MOUSE Q8BGT8 Q8BZJ1 Q8C0X3 Q8CFU1 Q8R0C1 uc007fnz.1 uc007fnz.2 uc007fnz.3 uc007fnz.4 May play a role in the development of the central system. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGT8-1; Sequence=Displayed; Name=2; IsoId=Q8BGT8-2; Sequence=VSP_034070; Belongs to the PHYHIP family. Sequence=AAI25000.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; Sequence=BAC28713.1; Type=Frameshift; Evidence=; molecular_function cytoplasm mitochondrion biological_process uc007fnz.1 uc007fnz.2 uc007fnz.3 uc007fnz.4 
ENSMUST00000046514.13 Eprs1 ENSMUST00000046514.13 glutamyl-prolyl-tRNA synthetase 1, transcript variant 1 (from RefSeq NM_029735.2) E9QKC4 ENSMUST00000046514.1 ENSMUST00000046514.10 ENSMUST00000046514.11 ENSMUST00000046514.12 ENSMUST00000046514.2 ENSMUST00000046514.3 ENSMUST00000046514.4 ENSMUST00000046514.5 ENSMUST00000046514.6 ENSMUST00000046514.7 ENSMUST00000046514.8 ENSMUST00000046514.9 Eprs Eprs1 NM_029735 Q3UFJ2 Q4VC16 Q8CGC7 Qprs SYEP_MOUSE uc007dzg.1 uc007dzg.2 uc007dzg.3 Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L- glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (By similarity). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). Reaction=ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L- glutamyl-tRNA(Glu); Xref=Rhea:RHEA:23540, Rhea:RHEA-COMP:9663, Rhea:RHEA-COMP:9680, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78520, ChEBI:CHEBI:456215; EC=6.1.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23541; Evidence=; Reaction=ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl- tRNA(Pro); Xref=Rhea:RHEA:14305, Rhea:RHEA-COMP:9700, Rhea:RHEA- COMP:9702, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:60039, ChEBI:CHEBI:78442, ChEBI:CHEBI:78532, ChEBI:CHEBI:456215; EC=6.1.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14306; Evidence=; Homodimer. Part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that is composed of the tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18. Forms a linear complex that contains MARS1, EEF1E1, EPRS1 and AIMP2 that is at the core of the multisubunit complex (PubMed:12060739). Interacts with TARS3 (By similarity). Interacts with DUS2L (By similarity). Component of the GAIT complex which is composed of EPRS1, RPL13A and GAPDH (PubMed:23071094). Interacts (phosphorylated at Ser-999) with SLC27A1; mediates the translocation of SLC27A1 from the cytoplasm to the plasma membrane thereby increasing the uptake of long-chain fatty acids (PubMed:28178239). Cytoplasm, cytosol Membrane ; Peripheral membrane protein Note=Translocates from cytosol to membranes upon phosphorylation at Ser-999. The WHEP-TRS domains are involved in RNA binding. Phosphorylated at Ser-999 by RPS6KB1; triggers EPRS1 release from the aminoacyl-tRNA synthetase multienzyme complex. In monocytes, the IFN-gamma-induced phosphorylation at Ser-999 releases EPRS1 from the aminoacyl-tRNA synthetase multienzyme complex, allowing its association with the GAIT complex. Phosphorylation at Ser-999 is specifically required for the RPL13A-mediated interaction of the GAIT complex with eIF4G (By similarity). Phosphorylation at Ser-999 by RPS6KB1, is also induced by insulin through activation of the mTORC1 signaling pathway and promotes the interaction of EPRS1 with SLC27A1 (PubMed:28178239). In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily. In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family. Sequence=AAH40802.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; nucleotide binding RNA binding catalytic activity aminoacyl-tRNA ligase activity glutamate-tRNA ligase activity proline-tRNA ligase activity protein binding ATP binding cytoplasm cytosol plasma membrane translation regulation of translation tRNA aminoacylation for protein translation glutamyl-tRNA aminoacylation prolyl-tRNA aminoacylation metabolic process zinc ion binding membrane ligase activity aminoacyl-tRNA synthetase multienzyme complex negative regulation of translation cellular response to insulin stimulus RNA stem-loop binding identical protein binding protein homodimerization activity tRNA aminoacylation long-chain fatty acid import metal ion binding GTPase binding cellular response to interferon-gamma GAIT complex ribonucleoprotein complex uc007dzg.1 uc007dzg.2 uc007dzg.3 
ENSMUST00000046515.15 Nceh1 ENSMUST00000046515.15 neutral cholesterol ester hydrolase 1 (from RefSeq NM_178772.4) Aadacl1 ENSMUST00000046515.1 ENSMUST00000046515.10 ENSMUST00000046515.11 ENSMUST00000046515.12 ENSMUST00000046515.13 ENSMUST00000046515.14 ENSMUST00000046515.2 ENSMUST00000046515.3 ENSMUST00000046515.4 ENSMUST00000046515.5 ENSMUST00000046515.6 ENSMUST00000046515.7 ENSMUST00000046515.8 ENSMUST00000046515.9 Kiaa1363 NCEH1_MOUSE NM_178772 Q69ZL0 Q8BLF1 Q8BZK3 uc008otl.1 uc008otl.2 uc008otl.3 Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2- acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:18164358, PubMed:20625037). May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (PubMed:18782767). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (PubMed:15840715, PubMed:16978018, PubMed:18164358). Reaction=a 1-O-alkyl-2-acetyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + acetate + H(+); Xref=Rhea:RHEA:11552, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15850, ChEBI:CHEBI:16291, ChEBI:CHEBI:30089; EC=3.1.1.71; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11553; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn- glycerol + acetate + H(+); Xref=Rhea:RHEA:38563, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:34115, ChEBI:CHEBI:75936; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38564; Evidence=; Reaction=a cholesterol ester + H2O = a fatty acid + cholesterol + H(+); Xref=Rhea:RHEA:36403, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:17002, ChEBI:CHEBI:28868; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36404; Evidence=; Reaction=cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+); Xref=Rhea:RHEA:33875, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30823, ChEBI:CHEBI:46898; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33876; Evidence=; Inhibited by bulky trifluoromethyl ketones. pH dependence: Optimum pH is 7.2 for cholesterol ester hydrolysis. ; Cell membrane ; Single-pass type II membrane protein Microsome Present in brain, heart, kidney, lung, spinal cord and testis but not liver (at protein level). Expressed in peritoneal macrophages and kidney. N-glycosylated. Mice are phenotypically normal but more sensitive to organophosphorus insecticide toxicity. Belongs to the 'GDXG' lipolytic enzyme family. Sequence=BAD32436.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; endoplasmic reticulum protein dephosphorylation lipid metabolic process xenobiotic metabolic process catabolic process membrane integral component of membrane lipid catabolic process hydrolase activity serine hydrolase activity short-chain carboxylesterase activity phosphate ion binding intracellular membrane-bounded organelle carboxylic ester hydrolase activity SMAD protein signal transduction uc008otl.1 uc008otl.2 uc008otl.3 
ENSMUST00000046518.12 Itpk1 ENSMUST00000046518.12 inositol 1,3,4-triphosphate 5/6 kinase (from RefSeq NM_172584.3) ENSMUST00000046518.1 ENSMUST00000046518.10 ENSMUST00000046518.11 ENSMUST00000046518.2 ENSMUST00000046518.3 ENSMUST00000046518.4 ENSMUST00000046518.5 ENSMUST00000046518.6 ENSMUST00000046518.7 ENSMUST00000046518.8 ENSMUST00000046518.9 ITPK1_MOUSE Itpk1 NM_172584 Q8BYN3 Q8K0J6 Q8R0Z0 uc007ouj.1 uc007ouj.2 uc007ouj.3 Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha- induced apoptosis by interfering with the activation of TNFRSF1A- associated death domain. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis. Reaction=1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo- inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+); Xref=Rhea:RHEA:12452, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57539, ChEBI:CHEBI:57733, ChEBI:CHEBI:456216; EC=2.7.1.134; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12453; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:12454; Evidence=; Reaction=1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+); Xref=Rhea:RHEA:13253, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57895, ChEBI:CHEBI:58414, ChEBI:CHEBI:456216; EC=2.7.1.159; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13254; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:13255; Evidence=; Reaction=1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+); Xref=Rhea:RHEA:20940, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57660, ChEBI:CHEBI:58414, ChEBI:CHEBI:456216; EC=2.7.1.159; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20941; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:20942; Evidence=; Reaction=1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+); Xref=Rhea:RHEA:70287, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57660, ChEBI:CHEBI:189099, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70288; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70289; Evidence=; Reaction=1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D- myo-inositol 3,4,5,6-tetrakisphosphate; Xref=Rhea:RHEA:70263, ChEBI:CHEBI:57539, ChEBI:CHEBI:57660, ChEBI:CHEBI:57733, ChEBI:CHEBI:58414; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70264; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70265; Evidence=; Reaction=1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D- myo-inositol 3,4,5,6-tetrakisphosphate; Xref=Rhea:RHEA:70271, ChEBI:CHEBI:57539, ChEBI:CHEBI:57733, ChEBI:CHEBI:57895, ChEBI:CHEBI:58414; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70272; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70273; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions per subunit. ; Monomer. Interacts with GPS1/COPS1. Acetylation by EP300 and CREBBP destabilizes ITPK1, and down- regulates enzymatic activity. Deacetylated by SIRT1. Belongs to the ITPK1 family. nucleotide binding magnesium ion binding inositol tetrakisphosphate 6-kinase activity ATP binding cytoplasm kinase activity phosphorylation apical plasma membrane transferase activity hydrolase activity isomerase activity neural tube development inositol trisphosphate metabolic process metal ion binding inositol tetrakisphosphate 1-kinase activity inositol-1,3,4-trisphosphate 6-kinase activity inositol-1,3,4-trisphosphate 5-kinase activity inositol phosphorylation necroptotic process uc007ouj.1 uc007ouj.2 uc007ouj.3 
ENSMUST00000046520.13 Fkbp14 ENSMUST00000046520.13 FK506 binding protein 14, transcript variant 10 (from RefSeq NR_177286.1) ENSMUST00000046520.1 ENSMUST00000046520.10 ENSMUST00000046520.11 ENSMUST00000046520.12 ENSMUST00000046520.2 ENSMUST00000046520.3 ENSMUST00000046520.4 ENSMUST00000046520.5 ENSMUST00000046520.6 ENSMUST00000046520.7 ENSMUST00000046520.8 ENSMUST00000046520.9 Fkbp14 NR_177286 Q542Q0 Q542Q0_MOUSE uc009bzy.1 uc009bzy.2 uc009bzy.3 Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence= protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity calcium ion binding isomerase activity uc009bzy.1 uc009bzy.2 uc009bzy.3 
ENSMUST00000046521.14 Bcl9 ENSMUST00000046521.14 B cell CLL/lymphoma 9 (from RefSeq NM_029933.4) B2RQC0 BCL9_MOUSE ENSMUST00000046521.1 ENSMUST00000046521.10 ENSMUST00000046521.11 ENSMUST00000046521.12 ENSMUST00000046521.13 ENSMUST00000046521.2 ENSMUST00000046521.3 ENSMUST00000046521.4 ENSMUST00000046521.5 ENSMUST00000046521.6 ENSMUST00000046521.7 ENSMUST00000046521.8 ENSMUST00000046521.9 NM_029933 Q67FX9 Q8BUJ8 Q8VE74 Q9D219 uc008qot.1 uc008qot.2 uc008qot.3 Promotes beta-catenin's transcriptional activity. Involved in signal transduction through the Wnt pathway (By similarity). Binds to beta-catenin (CTNNB1), PYGO1 and PYGO2; the interaction with PYGO1 increases PYGO1 affinity to histone H3 methylated at 'Lys 4'. Nucleus Belongs to the BCL9 family. Sequence=AAH19641.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; transcription coactivator activity nucleus cytoplasm Golgi apparatus cis-Golgi network beta-catenin binding myotube differentiation involved in skeletal muscle regeneration Wnt signaling pathway somatic stem cell population maintenance skeletal muscle cell differentiation positive regulation of transcription from RNA polymerase II promoter canonical Wnt signaling pathway beta-catenin-TCF complex uc008qot.1 uc008qot.2 uc008qot.3 
ENSMUST00000046522.13 Btnl9 ENSMUST00000046522.13 butyrophilin-like 9 (from RefSeq NM_172793.2) B7ZC64 B9EKA9 BTNL9_MOUSE ENSMUST00000046522.1 ENSMUST00000046522.10 ENSMUST00000046522.11 ENSMUST00000046522.12 ENSMUST00000046522.2 ENSMUST00000046522.3 ENSMUST00000046522.4 ENSMUST00000046522.5 ENSMUST00000046522.6 ENSMUST00000046522.7 ENSMUST00000046522.8 ENSMUST00000046522.9 NM_172793 Q80V04 Q811T7 Q8BJE2 uc007ipu.1 uc007ipu.2 uc007ipu.3 Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BJE2-1; Sequence=Displayed; Name=2; IsoId=Q8BJE2-2; Sequence=VSP_042501, VSP_042502, VSP_042503; Belongs to the immunoglobulin superfamily. BTN/MOG family. Sequence=CAX15495.1; Type=Erroneous gene model prediction; Evidence=; receptor binding external side of plasma membrane membrane integral component of membrane regulation of immune response T cell receptor signaling pathway uc007ipu.1 uc007ipu.2 uc007ipu.3 
ENSMUST00000046525.10 Kremen2 ENSMUST00000046525.10 kringle containing transmembrane protein 2 (from RefSeq NM_028416.2) ENSMUST00000046525.1 ENSMUST00000046525.2 ENSMUST00000046525.3 ENSMUST00000046525.4 ENSMUST00000046525.5 ENSMUST00000046525.6 ENSMUST00000046525.7 ENSMUST00000046525.8 ENSMUST00000046525.9 KREM2_MOUSE NM_028416 Q0VBR6 Q8K1S7 uc008atd.1 uc008atd.2 uc008atd.3 Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822). Interacts with ERLEC1 (PubMed:16531414). Forms a ternary complex with DKK1 and LRP6 (PubMed:12050670). Membrane ; Single-pass type I membrane protein Expressed in the developing brain and developing limb buds. Binding to ERLEC1 is mediated by the oligosaccharides linked to the kringle domain. Animals with a double knockout of KREM1 and KREM2 exhibit enhanced Wnt signaling accompanied by ectopic postaxial forelimb digits and expanded apical ectodermal ridges. They also exhibit increased bone volume and bone formation rates. Triple knockout mice KREM1/KREM2/DKK1 exhibit enhanced growth of ectopic digits. protein binding membrane integral component of membrane Wnt signaling pathway negative regulation of ossification limb development uc008atd.1 uc008atd.2 uc008atd.3 
ENSMUST00000046532.4 Gjb3 ENSMUST00000046532.4 gap junction protein, beta 3, transcript variant 1 (from RefSeq NM_001160012.2) CXB3_MOUSE Cxn-31 ENSMUST00000046532.1 ENSMUST00000046532.2 ENSMUST00000046532.3 NM_001160012 P28231 uc008uut.1 uc008uut.2 uc008uut.3 uc008uut.4 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Interacts with CNST. P28231; P23242: Gja1; NbExp=2; IntAct=EBI-1767245, EBI-298630; Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Belongs to the connexin family. Beta-type (group I) subfamily. in utero embryonic development placenta development protein binding cytoplasm plasma membrane cell-cell junction gap junction connexin complex cell communication spermatogenesis membrane integral component of membrane cell junction intracellular membrane-bounded organelle skin development cellular response to retinoic acid uc008uut.1 uc008uut.2 uc008uut.3 uc008uut.4 
ENSMUST00000046533.9 Prr7 ENSMUST00000046533.9 proline rich 7 (synaptic) (from RefSeq NM_001030296.4) ENSMUST00000046533.1 ENSMUST00000046533.2 ENSMUST00000046533.3 ENSMUST00000046533.4 ENSMUST00000046533.5 ENSMUST00000046533.6 ENSMUST00000046533.7 ENSMUST00000046533.8 NM_001030296 PRR7_MOUSE Q3V0I2 uc007qrb.1 uc007qrb.2 uc007qrb.3 uc007qrb.4 Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (By similarity). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:27657535). Might promote apoptosis in T cells (By similarity). Forms a complex with NMDA receptor zeta subunit GRIN1 and epsilon subunit GRIN2B (By similarity). Interacts with GRIN2B (By similarity). Interacts with GRIN1; the interaction is reduced upon NMDA receptor activity (By similarity). Found in a postsynaptic membrane complex with DLG4 and GRIN1 (By similarity). Interacts with DLG4 (via PDZ3 domain and to lesser degree via PDZ2 domain) (By similarity). Interacts with JUN (PubMed:27458189). Found in a complex with JUN and FBXW7 (By similarity). Interacts with JUN and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (By similarity). Interacts with SRC (By similarity). Cell membrane ; Single-pass type III membrane protein Postsynaptic cell membrane ; Single-pass type III membrane protein Postsynaptic density membrane Cytoplasm, perinuclear region Synapse Cell projection, dendrite Nucleus Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern. Translocates from synapses to nuclei following NMDA receptor activity (By similarity). Highly expressed in brain, moderately expressed in lymph nodes and T cells and low expression in thymus and spleen. Expressed in single positive progenitor thymocytes, particularly in CD8 single positive thymocytes. Palmitoylated. Tyrosine phosphorylated, possibly by SRC. No visible phenotype. Mice are viable and fertile. T-cell and B-cell development are normal. T cell receptor signaling and activation induced cell death appear normal. Small reduction of CD4 single positive thymocytes. adaptive immune response immune system process nucleus cytoplasm plasma membrane positive regulation of cell death postsynaptic density membrane integral component of membrane cell junction T cell differentiation dendrite negative regulation of protein ubiquitination long-chain fatty acid binding cell projection neuron projection positive regulation of apoptotic process ubiquitin-like protein ligase binding macromolecular complex binding synapse postsynaptic membrane perinuclear region of cytoplasm glutamatergic synapse postsynaptic density, intracellular component postsynapse to nucleus signaling pathway protein tyrosine kinase binding positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway uc007qrb.1 uc007qrb.2 uc007qrb.3 uc007qrb.4 
ENSMUST00000046548.14 Lgr4 ENSMUST00000046548.14 leucine-rich repeat-containing G protein-coupled receptor 4 (from RefSeq NM_172671.2) A2ARI3 A2ARI4 ENSMUST00000046548.1 ENSMUST00000046548.10 ENSMUST00000046548.11 ENSMUST00000046548.12 ENSMUST00000046548.13 ENSMUST00000046548.2 ENSMUST00000046548.3 ENSMUST00000046548.4 ENSMUST00000046548.5 ENSMUST00000046548.6 ENSMUST00000046548.7 ENSMUST00000046548.8 ENSMUST00000046548.9 Gpr48 LGR4_MOUSE NM_172671 Q6PHA3 Q80T31 Q8BXS9 uc008lmq.1 uc008lmq.2 Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (PubMed:24353284). Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (PubMed:32493844). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2ARI4-1; Sequence=Displayed; Name=2; IsoId=A2ARI4-2; Sequence=VSP_047137; During limb development, at 14.5 dpc, expressed in the mesenchyme, but not in the overlying ectoderm of the limb bud. In developing lungs, at 14.5 dpc, expressed at low levels in both the epithelium and mesenchyme lineages. Expressed in a circadian manner in the liver. Strong variations in phenotypes, probably depending on the strain background used in the different experiments. According to a first report done in a C57BL/6 background, mice show intra-uterine growth retardation leading to embryonic and perinatal lethality (PubMed:15192078). A lethal phenotype was confirmed by other groups. In some cases however, few mice survive until adulthood. Mice that survive show wide spectrum of anterior segment dysgenesis phenotypes, including microphthalmia, iris hypoplasia, irdiocorneal angle malformation, cornea dysgenesis and cataract (PubMed:18424556). Defects in osteoblast differentiation and mineralization during embryonic bone formation are also observed. Postnatal mice that survive show defects in bone remodeling (PubMed:19605502). According to other reports done in other strain backgrounds, mice do not die and display defects in the male reproductive tract during the postnatal period (PubMed:16406039, PubMed:17079737, PubMed:23533175). Mice also show small kidneys, in which the total number and density of the glomeruli are decreased (PubMed:16785743). The use of conditional knockouts, leads to defects in hair placode formation, possibly due to reduced keratinocyte migration (PubMed:17079737, PubMed:17850793). Decrease in epithelial cell proliferation and strong reduction in terminal differentiation of Paneth cells in postnatal intestinal crypts (PubMed:21508962, PubMed:23393138). Fetuses display transient anemia during midgestation and abnormal definitive erythropoiesis (PubMed:18955481). Mice are also more susceptible and have much higher mortality to lipopolysaccharide (LPS) stimulation due to over-activated innate immune response (PubMed:23589304). Conditional knockout of both Lgr4 and Lgr5 in the gut results in Wnt signaling inhibition and results in the rapid demise of intestinal crypts (PubMed:21727895). Simultaneous knockdown of LGR4, LGR5 and LGR6 results in developmental phenotypes, such as cleft palate and ankyloglossia, but not in tetra- amelia with lung agenesis (PubMed:29769720). Belongs to the G-protein coupled receptor 1 family. osteoblast differentiation hair follicle development immune system process transmembrane signaling receptor activity protein binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway multicellular organism development spermatogenesis axon guidance circadian rhythm heparin binding membrane integral component of membrane Wnt signaling pathway protein-hormone receptor activity cell differentiation bone mineralization male genitalia development circadian regulation of gene expression negative regulation of toll-like receptor signaling pathway tube morphogenesis intestinal stem cell homeostasis innate immune response negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated bone remodeling Roundabout binding rhythmic process digestive tract development epithelial cell proliferation negative regulation of cytokine secretion negative chemotaxis canonical Wnt signaling pathway involved in metanephric kidney development cell differentiation involved in metanephros development metanephric glomerulus development metanephric nephron tubule morphogenesis positive regulation of branching involved in ureteric bud morphogenesis positive regulation of canonical Wnt signaling pathway epithelial cell proliferation involved in renal tubule morphogenesis G-protein coupled receptor activity uc008lmq.1 uc008lmq.2 
ENSMUST00000046549.5 Apobec2 ENSMUST00000046549.5 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 (from RefSeq NM_009694.3) ABEC2_MOUSE ENSMUST00000046549.1 ENSMUST00000046549.2 ENSMUST00000046549.3 ENSMUST00000046549.4 NM_009694 Q9WV35 uc008cxx.1 uc008cxx.2 uc008cxx.3 Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Reaction=cytidine(6666) in apoB mRNA + H(+) + H2O = NH4(+) + uridine(6666) in apoB mRNA; Xref=Rhea:RHEA:21772, Rhea:RHEA- COMP:13888, Rhea:RHEA-COMP:13889, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:65315, ChEBI:CHEBI:82748; EC=3.5.4.36; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 Zn(2+) ion per subunit. ; Homotetramer. Expressed exclusively in heart and skeletal muscle. Belongs to the cytidine and deoxycytidylate deaminase family. RNA binding catalytic activity cytidine deaminase activity nucleus cytoplasm mRNA processing cytidine deamination cytidine to uridine editing mRNA modification hydrolase activity identical protein binding metal ion binding DNA demethylation uc008cxx.1 uc008cxx.2 uc008cxx.3 
ENSMUST00000046557.6 Akap14 ENSMUST00000046557.6 A kinase anchor protein 14 (from RefSeq NM_001033785.2) Akap14 ENSMUST00000046557.1 ENSMUST00000046557.2 ENSMUST00000046557.3 ENSMUST00000046557.4 ENSMUST00000046557.5 NM_001033785 Q3V0I7 Q3V0I7_MOUSE uc009syh.1 uc009syh.2 This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The human ortholog of this gene has been characterized. It is reported to be enriched in airway cilia and to regulate ciliary beat frequency by anchoring the protein kinase A holoenzyme near substrates in the axoneme. [provided by RefSeq, May 2013]. ##Evidence-Data-START## Transcript exon combination :: AK133120.1, BC147265.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## axoneme cAMP-dependent protein kinase complex biological_process kinase activity phosphorylation protein kinase A regulatory subunit binding sperm fibrous sheath protein kinase A binding uc009syh.1 uc009syh.2 
ENSMUST00000046565.13 Arx ENSMUST00000046565.13 aristaless related homeobox, transcript variant 1 (from RefSeq NM_007492.4) A2A4G9 ARX_MOUSE ENSMUST00000046565.1 ENSMUST00000046565.10 ENSMUST00000046565.11 ENSMUST00000046565.12 ENSMUST00000046565.2 ENSMUST00000046565.3 ENSMUST00000046565.4 ENSMUST00000046565.5 ENSMUST00000046565.6 ENSMUST00000046565.7 ENSMUST00000046565.8 ENSMUST00000046565.9 NM_007492 O35085 Q9QYT4 uc009tsr.1 uc009tsr.2 uc009tsr.3 uc009tsr.4 uc009tsr.5 This gene encodes a transcription factor that plays an important role in the development of forebrain. Male mice lacking this gene have smaller brains, olfactory bulbs and testes, and die within half a day after birth. Mice lacking this gene specifically in ganglionic eminence-derived neurons, including cortical interneurons, develop seizures. Mutations in this gene have been demonstrated to cause mouse phenotypes resembling human X-linked lissencephaly and cognitive disability with epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Transcription factor (By similarity). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C (By similarity). Positively modulates transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (By similarity). Required for normal brain development (PubMed:12379852). Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (PubMed:12379852, PubMed:31691806). May also be involved in axonal guidance in the floor plate (PubMed:9256348). Nucleus Expressed in the developing forebrain and also in the floor plate (PubMed:9256348). Expressed in the interstitium of the male gonad at 14.5 dpc, but only weakly in a region of the female gonad proximal to the mesonephros (PubMed:12379852). Hemizygous knockout males were born at 19.5 dpc and died within a half day (PubMed:12379852). Neonatal males have small brains, small olfactory bulbs, small testes, hypoplasia of the seminal vesicle and abnormally enlarged seminiferous tubules (PubMed:12379852). Abnormal morphology in each of the developing brain regions in which ARX is normally expressed (PubMed:12379852). Suppressed proliferation and nearly normal migration of neuroepithelial cells in the neocortex (PubMed:12379852). Aberrant formation of many nerve fiber tracts at 19.5 dpc (PubMed:12379852). Abnormal primary migration of GABAergic interneurons from the ganglionic eminence (PubMed:12379852). Abolished expression of wingless-related WNT8B and LIM homeobox protein LHX9 in the thalamic eminence at 12.5 dpc, and decreased expression of DLX1 in the ventral thalamus at 12.5 dpc (PubMed:12379852). Testes have a dysplastic interstitium, probably owing to a considerable decrease in cells containing an abundant cytoplasm as the interstitium is occupied predominantly by fibroblast-like cells (PubMed:12379852). Expression of Leydig cell marker HSD3B1 is severely diminished in the interstitial region of testes, suggesting that Leydig cell differentiation is blocked (PubMed:12379852). Expression of KDM5C is reduced at both mRNA and protein levels (PubMed:31691806). Increased expression of SYN1, SCN2A and some isoforms of BDNF (PubMed:31691806). Belongs to the paired homeobox family. Bicoid subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding neuron migration DNA binding chromatin binding nucleus regulation of transcription, DNA-templated multicellular organism development nervous system development axon guidance positive regulation of gene expression globus pallidus development olfactory bulb development cerebral cortex tangential migration embryonic olfactory bulb interneuron precursor migration cell proliferation in forebrain cerebral cortex GABAergic interneuron migration cell differentiation forebrain development regulation of cell proliferation sequence-specific DNA binding lipid digestion positive regulation of organ growth epithelial cell fate commitment uc009tsr.1 uc009tsr.2 uc009tsr.3 uc009tsr.4 uc009tsr.5 
ENSMUST00000046575.17 Ptov1 ENSMUST00000046575.17 prostate tumor over expressed gene 1 (from RefSeq NM_133949.2) ENSMUST00000046575.1 ENSMUST00000046575.10 ENSMUST00000046575.11 ENSMUST00000046575.12 ENSMUST00000046575.13 ENSMUST00000046575.14 ENSMUST00000046575.15 ENSMUST00000046575.16 ENSMUST00000046575.2 ENSMUST00000046575.3 ENSMUST00000046575.4 ENSMUST00000046575.5 ENSMUST00000046575.6 ENSMUST00000046575.7 ENSMUST00000046575.8 ENSMUST00000046575.9 NM_133949 PTOV1_MOUSE Q91VU8 Q9CTC2 uc009grk.1 uc009grk.2 May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. May interact with CREBBP. Interacts with FLOT1. Cytoplasm Nucleus Cell membrane Cytoplasm, perinuclear region Note=Translocates from the cytoplasm to the nucleus at the onset of S-phase. Also localizes to lipid rafts. Ubiquitinated by the CRL2(KLHDC2) complex, which recognizes the diglycine (Gly-Gly) at the C-terminus, leading to its degradation. Ubiquitinated by the CRL2(APPBP2) complex, which recognizes the Arg- Xaa-Xaa-Gly sequence at the C-terminus, leading to its degradation. Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily. Despite sequence similarity to MED25, to date this protein has not been identified as a component of the Mediator complex. nucleus cytoplasm plasma membrane membrane nuclear transcription factor complex positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm uc009grk.1 uc009grk.2 
ENSMUST00000046587.8 Scamp5 ENSMUST00000046587.8 secretory carrier membrane protein 5, transcript variant 2 (from RefSeq NM_020270.3) ENSMUST00000046587.1 ENSMUST00000046587.2 ENSMUST00000046587.3 ENSMUST00000046587.4 ENSMUST00000046587.5 ENSMUST00000046587.6 ENSMUST00000046587.7 NM_020270 Q9JKD3 SCAM5_MOUSE uc009pux.1 uc009pux.2 uc009pux.3 uc009pux.4 This gene encodes a member of the Scamp (secretory carrier membrane protein) family. The encoded protein may be involved in neuronal vesicle trafficking. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity). Interacts (via C-terminal part) with SYT1 and SYT2; interaction with synaptotagmins making a link with the SNARE molecules. Interacts with SLC9A7 (By similarity). Cell membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Note=Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles (By similarity). Brain-specific. Expressed late in development coincident with the elaboration of mature synapses. Belongs to the SCAMP family. SCAMP5 subfamily. Golgi membrane endosome Golgi apparatus plasma membrane exocytosis synaptic vesicle protein transport membrane integral component of membrane cell junction integral component of synaptic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle trans-Golgi network membrane response to endoplasmic reticulum stress macromolecular complex binding synapse negative regulation of endocytosis positive regulation of calcium ion-dependent exocytosis positive regulation of cytokine secretion recycling endosome membrane regulation of synaptic vesicle endocytosis uc009pux.1 uc009pux.2 uc009pux.3 uc009pux.4 
ENSMUST00000046589.4 Cst13 ENSMUST00000046589.4 cystatin 13, transcript variant 3 (from RefSeq NR_184803.1) CST13_MOUSE Cst13 Cymg1 ENSMUST00000046589.1 ENSMUST00000046589.2 ENSMUST00000046589.3 NR_184803 Q80ZN5 Q9DAP1 uc008mtq.1 uc008mtq.2 uc008mtq.3 May perform a specialized role during sperm development and maturation. Secreted Cytoplasm Note=According to PubMed:15645076 it is cytoplasmic. Expressed exclusively in testis. Found in spermatagonia, spermatocytes, round spermatids, elongating spermatids and spermatozoa. Expressed only in the adult. Levels are low 1 week postpartum, steadily increase 2 to 5 weeks postpartum, are highest at 7 weeks and then drop to back the levels found at 5 weeks. Belongs to the cystatin family. cysteine-type endopeptidase inhibitor activity extracellular region cytoplasm negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc008mtq.1 uc008mtq.2 uc008mtq.3 
ENSMUST00000046603.15 Gak ENSMUST00000046603.15 cyclin G associated kinase, transcript variant 1 (from RefSeq NM_153569.2) A0A0R4J0F6 A0A0R4J0F6_MOUSE ENSMUST00000046603.1 ENSMUST00000046603.10 ENSMUST00000046603.11 ENSMUST00000046603.12 ENSMUST00000046603.13 ENSMUST00000046603.14 ENSMUST00000046603.2 ENSMUST00000046603.3 ENSMUST00000046603.4 ENSMUST00000046603.5 ENSMUST00000046603.6 ENSMUST00000046603.7 ENSMUST00000046603.8 ENSMUST00000046603.9 Gak NM_153569 uc008yoh.1 uc008yoh.2 uc008yoh.3 uc008yoh.4 Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. protein kinase activity ATP binding Golgi apparatus cytosol protein phosphorylation receptor-mediated endocytosis Golgi organization negative regulation of neuron projection development vesicle protein localization to Golgi apparatus intracellular membrane-bounded organelle clathrin coat disassembly clathrin-dependent endocytosis protein localization to plasma membrane Golgi to lysosome transport clathrin-coated pit assembly uc008yoh.1 uc008yoh.2 uc008yoh.3 uc008yoh.4 
ENSMUST00000046611.9 Cuzd1 ENSMUST00000046611.9 CUB and zona pellucida-like domains 1 (from RefSeq NM_008411.3) B2RU69 CUZD1_MOUSE Cuzd1 ENSMUST00000046611.1 ENSMUST00000046611.2 ENSMUST00000046611.3 ENSMUST00000046611.4 ENSMUST00000046611.5 ENSMUST00000046611.6 ENSMUST00000046611.7 ENSMUST00000046611.8 Itmap1 NM_008411 P70412 Q9CTZ7 uc009kbc.1 uc009kbc.2 Localized to zymogen granules, where it functions in trypsinogen activation (PubMed:12401800). May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (By similarity). Zymogen granule membrane ; Single-pass type I membrane protein Highly expressed in pancreatic acinar cells. Also expressed in epithelium of the uterus during late pregnancy but not detected in non-pregnant uterus or in a variety of other adult and fetal tissues. First detected in uterus 6 days prior to birth, increases daily to reach maximum levels 3 days before birth, abruptly decreases during the last 3 days of pregnancy and is almost undetectable by the first day after birth. Mice display increased severity of secretagogue- and diet-induced pancreatitis which seems to be due to impaired activation of trypsin. Sequence=AAC24898.2; Type=Frameshift; Evidence=; cell cycle cell adhesion female pregnancy hormone-mediated signaling pathway membrane integral component of membrane transport vesicle membrane cytoplasmic vesicle trypsinogen activation zymogen granule zymogen granule membrane cell division uc009kbc.1 uc009kbc.2 
ENSMUST00000046614.10 Gipc2 ENSMUST00000046614.10 GIPC PDZ domain containing family, member 2 (from RefSeq NM_016867.1) ENSMUST00000046614.1 ENSMUST00000046614.2 ENSMUST00000046614.3 ENSMUST00000046614.4 ENSMUST00000046614.5 ENSMUST00000046614.6 ENSMUST00000046614.7 ENSMUST00000046614.8 ENSMUST00000046614.9 GIPC2_MOUSE NM_016867 Q9CVG2 Q9Z2H7 Semcap2 uc008rsp.1 uc008rsp.2 uc008rsp.3 Probably interacts with SEMA5A. Q9Z2H7; Q64151: Sema4c; NbExp=3; IntAct=EBI-987119, EBI-987075; Cytoplasm Expressed in kidney and lung (at protein level). Belongs to the GIPC family. protein binding cytoplasm biological_process identical protein binding uc008rsp.1 uc008rsp.2 uc008rsp.3 
ENSMUST00000046633.10 Rimoc1 ENSMUST00000046633.10 RAB7A interacting MON1-CCZ1 complex subunit 1 (from RefSeq NM_145930.3) AW549877 ENSMUST00000046633.1 ENSMUST00000046633.2 ENSMUST00000046633.3 ENSMUST00000046633.4 ENSMUST00000046633.5 ENSMUST00000046633.6 ENSMUST00000046633.7 ENSMUST00000046633.8 ENSMUST00000046633.9 NM_145930 Q8BR90 Q91YM1 RIMC1_MOUSE Rimoc1 uc007vch.1 uc007vch.2 uc007vch.3 Plays an important role in the removal of damaged mitochondria via mitophagy by controlling the stability and localization of RAB7A (By similarity). Required for the recruitment of RAB7A and ATG9A vesicles to damaged mitochondria and promotes the stability of RAB7A by inhibiting its proteasomal degradation during mitophagy (By similarity). Interacts with the MON1A-CCZ1B complex. Interacts with GDP- bound RAB7A and promotes its interaction with the MON1A-CCZ1B complex. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BR90-1; Sequence=Displayed; Name=2; IsoId=Q8BR90-2; Sequence=VSP_034224, VSP_034225; Belongs to the RIMOC1 family. molecular_function nucleoplasm cytosol biological_process uc007vch.1 uc007vch.2 uc007vch.3 
ENSMUST00000046638.10 Mettl25 ENSMUST00000046638.10 methyltransferase like 25, transcript variant 1 (from RefSeq NM_207522.3) A0A0R4J0G2 A0A0R4J0G2_MOUSE ENSMUST00000046638.1 ENSMUST00000046638.2 ENSMUST00000046638.3 ENSMUST00000046638.4 ENSMUST00000046638.5 ENSMUST00000046638.6 ENSMUST00000046638.7 ENSMUST00000046638.8 ENSMUST00000046638.9 Mettl25 NM_207522 uc007gyo.1 uc007gyo.2 uc007gyo.3 uc007gyo.4 uc007gyo.1 uc007gyo.2 uc007gyo.3 uc007gyo.4 
ENSMUST00000046644.7 Tbca ENSMUST00000046644.7 tubulin cofactor A (from RefSeq NM_009321.3) ENSMUST00000046644.1 ENSMUST00000046644.2 ENSMUST00000046644.3 ENSMUST00000046644.4 ENSMUST00000046644.5 ENSMUST00000046644.6 NM_009321 Q5I0U7 Q5I0U7_MOUSE Tbca uc007rlx.1 uc007rlx.2 uc007rlx.3 Tubulin-folding protein; involved in the early step of the tubulin folding pathway. Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cytoplasm, cytoskeleton Belongs to the TBCA family. nucleolus cytoplasm cytoskeleton microtubule tubulin complex assembly post-chaperonin tubulin folding pathway microtubule cytoskeleton beta-tubulin binding uc007rlx.1 uc007rlx.2 uc007rlx.3 
ENSMUST00000046647.3 Tex46 ENSMUST00000046647.3 testis expressed 46 (from RefSeq NM_026300.2) 4930549C01Rik A3KG95 ENSMUST00000046647.1 ENSMUST00000046647.2 NM_026300 Q9CPU3 Q9CPU3_MOUSE Tex46 uc008vii.1 uc008vii.2 uc008vii.3 molecular_function cellular_component biological_process membrane integral component of membrane uc008vii.1 uc008vii.2 uc008vii.3 
ENSMUST00000046659.14 Dlgap3 ENSMUST00000046659.14 DLG associated protein 3, transcript variant 1 (from RefSeq NM_198618.6) DLGP3_MOUSE Dap3 ENSMUST00000046659.1 ENSMUST00000046659.10 ENSMUST00000046659.11 ENSMUST00000046659.12 ENSMUST00000046659.13 ENSMUST00000046659.2 ENSMUST00000046659.3 ENSMUST00000046659.4 ENSMUST00000046659.5 ENSMUST00000046659.6 ENSMUST00000046659.7 ENSMUST00000046659.8 ENSMUST00000046659.9 NM_198618 Q6PDX0 Q6PFD5 Q6XBF2 uc008uuo.1 uc008uuo.2 uc008uuo.3 uc008uuo.4 May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD- 95/SAP90 at the plasma membrane. Interacts with DLG4/PSD-95. Cell membrane ; Peripheral membrane protein Postsynaptic density Synapse Note=Postsynaptic density of neuronal cells. Highly expressed in central and peripherical nervous system (at protein level). Belongs to the SAPAP family. beta-amyloid binding plasma membrane postsynaptic density membrane protein domain specific binding signaling cell junction PDZ domain binding neuromuscular junction neuronal cell body dendritic spine synapse postsynaptic membrane binding, bridging macromolecular complex assembly scaffold protein binding glutamatergic synapse cholinergic synapse modification of synaptic structure postsynaptic specialization NMDA selective glutamate receptor complex uc008uuo.1 uc008uuo.2 uc008uuo.3 uc008uuo.4 
ENSMUST00000046662.8 Gm4847 ENSMUST00000046662.8 predicted gene 4847 (from RefSeq NM_001164312.1) ENSMUST00000046662.1 ENSMUST00000046662.2 ENSMUST00000046662.3 ENSMUST00000046662.4 ENSMUST00000046662.5 ENSMUST00000046662.6 ENSMUST00000046662.7 G3X946 G3X946_MOUSE Gm4847 NM_001164312 uc011wvm.1 uc011wvm.2 Reaction=H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N- dimethylaniline N-oxide + NADP(+); Xref=Rhea:RHEA:24468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16269, ChEBI:CHEBI:17735, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24469; Evidence=; Reaction=H(+) + hypotaurine + NADH + O2 = H2O + NAD(+) + taurine; Xref=Rhea:RHEA:74111, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57540, ChEBI:CHEBI:57853, ChEBI:CHEBI:57945, ChEBI:CHEBI:507393; EC=1.14.13.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74112; Evidence=; Reaction=H(+) + hypotaurine + NADPH + O2 = H2O + NADP(+) + taurine; Xref=Rhea:RHEA:69819, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:57853, ChEBI:CHEBI:58349, ChEBI:CHEBI:507393; EC=1.14.13.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69820; Evidence=; Reaction=NADPH + O2 + trimethylamine = H2O + NADP(+) + trimethylamine N-oxide; Xref=Rhea:RHEA:31979, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:15724, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58389; EC=1.14.13.148; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31980; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Endoplasmic reticulum membrane Belongs to the FMO family. monooxygenase activity N,N-dimethylaniline monooxygenase activity cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane oxidoreductase activity organelle membrane intracellular membrane-bounded organelle flavin adenine dinucleotide binding NADP binding oxidation-reduction process uc011wvm.1 uc011wvm.2 
ENSMUST00000046663.8 Dcbld2 ENSMUST00000046663.8 discoidin, CUB and LCCL domain containing 2, transcript variant 1 (from RefSeq NM_028523.3) A6X950 DCBD2_MOUSE ENSMUST00000046663.1 ENSMUST00000046663.2 ENSMUST00000046663.3 ENSMUST00000046663.4 ENSMUST00000046663.5 ENSMUST00000046663.6 ENSMUST00000046663.7 Esdn NM_028523 Q8BKI4 Q91ZV3 uc007zno.1 uc007zno.2 uc007zno.3 Membrane ; Single-pass type I membrane protein integral component of plasma membrane cell surface membrane integral component of membrane negative regulation of cell growth wound healing uc007zno.1 uc007zno.2 uc007zno.3 
ENSMUST00000046687.16 Spon1 ENSMUST00000046687.16 spondin 1, (f-spondin) extracellular matrix protein (from RefSeq NM_145584.2) ENSMUST00000046687.1 ENSMUST00000046687.10 ENSMUST00000046687.11 ENSMUST00000046687.12 ENSMUST00000046687.13 ENSMUST00000046687.14 ENSMUST00000046687.15 ENSMUST00000046687.2 ENSMUST00000046687.3 ENSMUST00000046687.4 ENSMUST00000046687.5 ENSMUST00000046687.6 ENSMUST00000046687.7 ENSMUST00000046687.8 ENSMUST00000046687.9 NM_145584 Q8K2Q8 Q8VCC9 SPON1_MOUSE uc009jhv.1 uc009jhv.2 uc009jhv.3 uc009jhv.4 Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP. Secreted, extracellular space, extracellular matrix Sequence=AAH30339.1; Type=Erroneous initiation; Evidence=; extracellular matrix structural constituent protein binding extracellular region cell adhesion positive regulation of protein processing extracellular matrix positive regulation of protein binding metal ion binding LBD domain binding negative regulation of beta-amyloid formation positive regulation of amyloid precursor protein catabolic process uc009jhv.1 uc009jhv.2 uc009jhv.3 uc009jhv.4 
ENSMUST00000046689.13 Resf1 ENSMUST00000046689.13 retroelement silencing factor 1, transcript variant 3 (from RefSeq NM_026054.3) ENSMUST00000046689.1 ENSMUST00000046689.10 ENSMUST00000046689.11 ENSMUST00000046689.12 ENSMUST00000046689.2 ENSMUST00000046689.3 ENSMUST00000046689.4 ENSMUST00000046689.5 ENSMUST00000046689.6 ENSMUST00000046689.7 ENSMUST00000046689.8 ENSMUST00000046689.9 Kiaa1551 NM_026054 Q5DTW7 Q5FWH0 Q7TNT1 Q8CCW3 Q8CCZ9 Q9CSA5 Q9CU82 RESF1_MOUSE Resf1 uc009eud.1 uc009eud.2 uc009eud.3 uc009eud.4 Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. Interacts with SETDB1. Nucleus Note=Localizes around gamma-tubulin during M phase. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5DTW7-1; Sequence=Displayed; Name=2; IsoId=Q5DTW7-3; Sequence=VSP_026863; Sequence=AAH89381.1; Type=Frameshift; Evidence=; Sequence=BAB28838.1; Type=Frameshift; Evidence=; Sequence=BAC27639.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC27639.1; Type=Frameshift; Evidence=; Sequence=BAD90453.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleus response to bacterium negative regulation of single stranded viral RNA replication via double stranded DNA intermediate positive regulation of methylation-dependent chromatin silencing histone methyltransferase binding gamma-tubulin complex uc009eud.1 uc009eud.2 uc009eud.3 uc009eud.4 
ENSMUST00000046709.9 Supt16 ENSMUST00000046709.9 SPT16, facilitates chromatin remodeling subunit (from RefSeq NM_033618.3) ENSMUST00000046709.1 ENSMUST00000046709.2 ENSMUST00000046709.3 ENSMUST00000046709.4 ENSMUST00000046709.5 ENSMUST00000046709.6 ENSMUST00000046709.7 ENSMUST00000046709.8 G3X956 G3X956_MOUSE NM_033618 Supt16 Supt16h uc007tor.1 uc007tor.2 uc007tor.3 Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Component of the FACT complex. Nucleus Chromosome Belongs to the peptidase M24 family. SPT16 subfamily. nucleus FACT complex uc007tor.1 uc007tor.2 uc007tor.3 
ENSMUST00000046717.13 Mga ENSMUST00000046717.13 Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'- AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor. (from UniProt A2AWL7) A2AWL6 A2AWL7 AF205935 ENSMUST00000046717.1 ENSMUST00000046717.10 ENSMUST00000046717.11 ENSMUST00000046717.12 ENSMUST00000046717.2 ENSMUST00000046717.3 ENSMUST00000046717.4 ENSMUST00000046717.5 ENSMUST00000046717.6 ENSMUST00000046717.7 ENSMUST00000046717.8 ENSMUST00000046717.9 Kiaa4252 MGAP_MOUSE Q3TS36 Q6A056 Q8BQX1 Q8CCL4 Q9QXJ5 uc289zqh.1 uc289zqh.2 Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'- AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ZMYND11 (By similarity). Interacts with MAX. Requires heterodimerization with MAX for E-box binding. Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=A2AWL7-1; Sequence=Displayed; Name=2; IsoId=A2AWL7-2; Sequence=VSP_034539, VSP_034540, VSP_034541, VSP_034542; Name=3; IsoId=A2AWL7-3; Sequence=VSP_034538; Name=4; IsoId=A2AWL7-4; Sequence=VSP_034536, VSP_034537; Expressed at 9.5 dpc, 10 dpc and 10.5 dpc in the limb buds, branchial arches and the tail region. Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain. Sequence=BAD32240.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cell fate specification DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity MLL1 complex cellular response to leukemia inhibitory factor uc289zqh.1 uc289zqh.2 
ENSMUST00000046735.11 Tex264 ENSMUST00000046735.11 testis expressed gene 264 ER-phagy receptor, transcript variant 3 (from RefSeq NM_001286498.1) E9Q137 ENSMUST00000046735.1 ENSMUST00000046735.10 ENSMUST00000046735.2 ENSMUST00000046735.3 ENSMUST00000046735.4 ENSMUST00000046735.5 ENSMUST00000046735.6 ENSMUST00000046735.7 ENSMUST00000046735.8 ENSMUST00000046735.9 NM_001286498 Q3TXY2 Q99LS5 Q9D7D9 TX264_MOUSE Tex264 uc009rkn.1 uc009rkn.2 uc009rkn.3 uc009rkn.4 Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins. Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure. Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN. Interacts (via the LIR motif) with ATG8 family proteins MAP1LC3A, MAP1LC3B, GABARAP and GABARAPL1. Interacts with VCP/p97; bridging VCP/p97 to covalent DNA-protein cross-links (DPCs). Interacts with TOP1 (when sumoylated). Endoplasmic reticulum membrane ; Single-pass type III membrane protein Cytoplasmic vesicle, autophagosome Cytoplasm, cytosol Nucleus Chromosome Note=Is trafficked from tubular ER to growing autophagosomes via its cytosolic LIR motif. Also found in the cytosol, nucleus and chromatin. In response to formation of covalent DNA-protein cross-links (DPCs), localizes to the nuclear periphery, and associates with DNA replication forks. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q137-1; Sequence=Displayed; Name=2; IsoId=E9Q137-2; Sequence=VSP_060780; The LIR motif in the cytosol-facing C-terminal region is involved in the interaction with ATG8 proteins. The disordered region is required for autophagosome binding and reticulophagy, probably via bridging the long distance between endoplasmic reticulum and autophagosome membranes, because ribosomes exist on endoplasmic reticulum membranes that attach to autophagic membranes. autophagosome membrane molecular_function endoplasmic reticulum membrane reticulophagy uc009rkn.1 uc009rkn.2 uc009rkn.3 uc009rkn.4 
ENSMUST00000046739.6 Ifi44l ENSMUST00000046739.6 interferon-induced protein 44 like (from RefSeq NM_031367.1) ENSMUST00000046739.1 ENSMUST00000046739.2 ENSMUST00000046739.3 ENSMUST00000046739.4 ENSMUST00000046739.5 F6ZI78 F6ZI78_MOUSE H28 Ifi44l NM_031367 uc290knr.1 uc290knr.2 This gene encodes a minor histocompatibility antigen that is involved in tissue graft rejection and is polymorphic in different mouse strains. The 5' region of this gene, including the translational start codon and the first 293 amino acids, is absent from the C57BL/6J genome. The encoded antigen is not thought to be expressed in C57BL/6J. [provided by RefSeq, Mar 2013]. ##Evidence-Data-START## Transcript exon combination :: AF336221.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## uc290knr.1 uc290knr.2 
ENSMUST00000046743.11 Cryzl2 ENSMUST00000046743.11 crystallin zeta like 2, transcript variant 5 (from RefSeq NM_001421432.1) Cryzl2 ENSMUST00000046743.1 ENSMUST00000046743.10 ENSMUST00000046743.2 ENSMUST00000046743.3 ENSMUST00000046743.4 ENSMUST00000046743.5 ENSMUST00000046743.6 ENSMUST00000046743.7 ENSMUST00000046743.8 ENSMUST00000046743.9 NM_001421432 Q3UAM2 Q3UNZ8 QORL2_MOUSE uc007ddj.1 uc007ddj.2 uc007ddj.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UNZ8-1; Sequence=Displayed; Name=2; IsoId=Q3UNZ8-2; Sequence=VSP_034229, VSP_034230; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. mitochondrion oxidoreductase activity oxidation-reduction process uc007ddj.1 uc007ddj.2 uc007ddj.3 
ENSMUST00000046745.7 Tgtp2 ENSMUST00000046745.7 T cell specific GTPase 2 (from RefSeq NM_001145164.1) ENSMUST00000046745.1 ENSMUST00000046745.2 ENSMUST00000046745.3 ENSMUST00000046745.4 ENSMUST00000046745.5 ENSMUST00000046745.6 Ifggb5 Irgb6 Mg21 NM_001145164 Q60711 Q62293 Q8BN19 TGTP1_MOUSE Tgtp1 uc007ipp.1 uc007ipp.2 uc007ipp.3 uc007ipp.4 Involved in innate cell-autonomous resistance to intracellular pathogens, such as Toxoplasma gondii (PubMed:19265156, PubMed:20109161, PubMed:24563254). During avirulent type II T. gondii infection, recruited to the parasitophorous vacuole (PV) membrane, leading to PV vesiculation and rupture, and subsequent digestion of the parasite within the cytosol (PubMed:19265156, PubMed:24563254). Not recruited to virulent type I T. gondii PV membrane (PubMed:19265156). May confer an antiviral state for vesicular stomatitis virus (PubMed:9725230). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; Cytoplasm Endoplasmic reticulum Golgi apparatus Note=In astrocytes stimulated with IFNG or TNF, diffuse cytoplasmic localization decreases and the protein partially relocalizes to the endoplasmic reticulum and Golgi apparatus (PubMed:19285957). Due to sequence similarity with Tgtp2, it is impossible to assign unambiguously experimental data published in the literature to Tgtp1 or Tgtp2 gene (Probable). Expressed in thymus and lymph nodes, predominantly T-cells. Not expressed by immature CD4(+) CD8(+) thymocytes (at protein level) (PubMed:7836757). Expressed in IFNG-stimulated macrophages (PubMed:7884320). Expressed at low levels in unstimulated astrocytes (PubMed:19285957). Due to sequence similarity with Tgtp2, it is impossible to assign unambiguously experimental data published in the literature to Tgtp1 or Tgtp2 gene. In macrophages, up-regulated by IFNG, but not by IL2, IL4, IL10, nor TNF (PubMed:7884320). Up-regulated by IFNG in lymph node cells and thymocytes and other cell types (PubMed:7836757, PubMed:9725230, PubMed:24563254). In astrocytes, up-regulated by TNF and IFNG; when both cytokines are combined, the effect is synergistic (PubMed:19285957). Due to sequence similarity with Tgtp2, it is impossible to assign unambiguously experimental data published in the literature to Tgtp1 or Tgtp2 gene (Probable). Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. The gene Tgtp1 belongs to a large family of eutherian IFNG- inducible GTPases, called immunity-related p47 GTPases, which comprises a variable amount of paralogs depending upon the species studied. In C57BL/6J mice, there is over 20 genes, whereas humans have only one ortholog. Tgtp1 closest paralog is Tgtp2. Both genes encode identical proteins. At the nucleotide sequence level, their CDSs differ at only 4 positions. Consequently it is almost impossible to assign unambiguously to one gene or the other experimental data published in the literature. nucleotide binding immune system process GTPase activity GTP binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus defense response immune response response to virus response to bacterium membrane hydrolase activity response to interferon-gamma response to interferon-alpha cellular response to interferon-beta innate immune response uc007ipp.1 uc007ipp.2 uc007ipp.3 uc007ipp.4 
ENSMUST00000046746.10 Igfbp7 ENSMUST00000046746.10 insulin-like growth factor binding protein 7, transcript variant 2 (from RefSeq NM_008048.4) ENSMUST00000046746.1 ENSMUST00000046746.2 ENSMUST00000046746.3 ENSMUST00000046746.4 ENSMUST00000046746.5 ENSMUST00000046746.6 ENSMUST00000046746.7 ENSMUST00000046746.8 ENSMUST00000046746.9 IBP7_MOUSE Mac25 NM_008048 O88812 Q61581 Q9EQW0 uc008xwf.1 uc008xwf.2 uc008xwf.3 uc008xwf.4 Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion (By similarity). Secreted. Expressed at high levels in lung, kidney, small intestine, testis and uterus and at moderate levels in liver. By retinoic acid. Modified_positions=77 , 94 ; Note=Partially edited. Position 77 seems to be edited at about 56% and position 94 at about 58%.; Sequence=BAB17228.1; Type=Erroneous initiation; Evidence=; regulation of cell growth extracellular matrix structural constituent insulin-like growth factor binding extracellular region extracellular space cell adhesion growth factor binding inner ear development regulation of steroid biosynthetic process uc008xwf.1 uc008xwf.2 uc008xwf.3 uc008xwf.4 
ENSMUST00000046750.14 Tspan33 ENSMUST00000046750.14 tetraspanin 33, transcript variant 1 (from RefSeq NM_146173.3) ENSMUST00000046750.1 ENSMUST00000046750.10 ENSMUST00000046750.11 ENSMUST00000046750.12 ENSMUST00000046750.13 ENSMUST00000046750.2 ENSMUST00000046750.3 ENSMUST00000046750.4 ENSMUST00000046750.5 ENSMUST00000046750.6 ENSMUST00000046750.7 ENSMUST00000046750.8 ENSMUST00000046750.9 NM_146173 Pen Q3TA03 Q8R3S2 TSN33_MOUSE uc009bec.1 uc009bec.2 uc009bec.3 uc009bec.4 This gene encodes a member of the tetraspanin family which typically have four transmembrane domains. The encoded protein may be involved in the regulation of erythropoiesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (By similarity). Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors (PubMed:17158226). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011). Homodimer; disulfide-linked (PubMed:17158226). Interacts (via extracellular domain) with ADAM10 (via extracellular domain) (PubMed:30463011). Interacts (via cytoplasmic domain) with PLEKHA7 (via WW domains); the interaction is dependent on PDZD11 being bound to PLEKHA7 and facilitates the docking of ADAM10 to zonula adherens (PubMed:30463011). Cell membrane ; Multi-pass membrane protein Cell junction, adherens junction Cytoplasm Note=Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R3S2-1; Sequence=Displayed; Name=2; IsoId=Q8R3S2-2; Sequence=VSP_024250; Predominantly expressed in erythroblasts. Belongs to the tetraspanin (TM4SF) family. cytoplasm plasma membrane integral component of plasma membrane adherens junction cell surface membrane integral component of membrane enzyme binding cell junction pore complex pore complex assembly protein maturation protein localization to plasma membrane tetraspanin-enriched microdomain uc009bec.1 uc009bec.2 uc009bec.3 uc009bec.4 
ENSMUST00000046751.13 Zmym6 ENSMUST00000046751.13 zinc finger, MYM-type 6, transcript variant 5 (from RefSeq NR_104366.1) D4Wsu24e ENSMUST00000046751.1 ENSMUST00000046751.10 ENSMUST00000046751.11 ENSMUST00000046751.12 ENSMUST00000046751.2 ENSMUST00000046751.3 ENSMUST00000046751.4 ENSMUST00000046751.5 ENSMUST00000046751.6 ENSMUST00000046751.7 ENSMUST00000046751.8 ENSMUST00000046751.9 NR_104366 Q8BS54 Q8BS54_MOUSE Zfp258 Zmym6 uc008uui.1 uc008uui.2 uc008uui.3 uc008uui.4 RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription from RNA polymerase II promoter cytoskeleton organization zinc ion binding regulation of cell morphogenesis uc008uui.1 uc008uui.2 uc008uui.3 uc008uui.4 
ENSMUST00000046755.14 Cobl ENSMUST00000046755.14 cordon-bleu WH2 repeat, transcript variant 1 (from RefSeq NM_172496.4) COBL_MOUSE ENSMUST00000046755.1 ENSMUST00000046755.10 ENSMUST00000046755.11 ENSMUST00000046755.12 ENSMUST00000046755.13 ENSMUST00000046755.2 ENSMUST00000046755.3 ENSMUST00000046755.4 ENSMUST00000046755.5 ENSMUST00000046755.6 ENSMUST00000046755.7 ENSMUST00000046755.8 ENSMUST00000046755.9 Kiaa0633 NM_172496 Q5NBX1 Q5NBX2 Q60859 Q6PAT4 Q7TQM9 Q80TV4 Q8C7Q0 Q8CE81 Q8CIM4 uc007ibd.1 uc007ibd.2 uc007ibd.3 uc007ibd.4 Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells. Identified in a complex composed of COBL, PACSIN1 and WASL. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X. Interacts (via WH2 domains) with actin monomers. Interacts with DBNL. Q5NBX1; Q9Z0W5: Pacsin1; Xeno; NbExp=14; IntAct=EBI-1550138, EBI-1550185; Q5NBX1; Q9QY17: Pacsin2; Xeno; NbExp=4; IntAct=EBI-1550138, EBI-491201; Q5NBX1; Q5I2Z0: Pacsin3; Xeno; NbExp=3; IntAct=EBI-1550138, EBI-7003023; Q5NBX1-1; P62161: Calm3; Xeno; NbExp=6; IntAct=EBI-16174243, EBI-397530; Q5NBX1-1; Q9Z0W5: Pacsin1; Xeno; NbExp=2; IntAct=EBI-16174243, EBI-1550185; Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton. Cell projection, ruffle. Cytoplasm. Note=Recruited to the cell membrane via interaction with PACSIN1 (By similarity). Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q5NBX1-1; Sequence=Displayed; Name=2; IsoId=Q5NBX1-2; Sequence=VSP_021615, VSP_021618; Name=3; IsoId=Q5NBX1-3; Sequence=VSP_021614; Name=4; IsoId=Q5NBX1-4; Sequence=VSP_021619, VSP_021620; Name=5; IsoId=Q5NBX1-5; Sequence=VSP_021616, VSP_021617; Detected in brain cortex and in the Purkinje cell layer in the cerebellum. Detected in hippocampus neurons, and at lower levels in testis, lung and spleen (at protein level). Detected in embryonic neural tube. Sequence=AAH23264.1; Type=Frameshift; Evidence=; Sequence=BAC65616.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; embryonic axis specification ruffle somite specification neural tube closure liver development actin binding actin monomer binding protein binding cytoplasm cytoskeleton plasma membrane cell cortex membrane actin filament polymerization axon dendrite notochord development floor plate development cell projection neuronal cell body dendritic growth cone axonal growth cone perinuclear region of cytoplasm digestive tract development collateral sprouting in absence of injury actin filament network formation actin crosslink formation positive regulation of dendrite development positive regulation of ruffle assembly actin filament uc007ibd.1 uc007ibd.2 uc007ibd.3 uc007ibd.4 
ENSMUST00000046763.13 Radx ENSMUST00000046763.13 RPA1 related single stranded DNA binding protein, X-linked, transcript variant 2 (from RefSeq NM_001346522.1) A2AGL6 ENSMUST00000046763.1 ENSMUST00000046763.10 ENSMUST00000046763.11 ENSMUST00000046763.12 ENSMUST00000046763.2 ENSMUST00000046763.3 ENSMUST00000046763.4 ENSMUST00000046763.5 ENSMUST00000046763.6 ENSMUST00000046763.7 ENSMUST00000046763.8 ENSMUST00000046763.9 NM_001346522 Q3TB47 Q8C779 RADX_MOUSE Radx uc009ukh.1 uc009ukh.2 uc009ukh.3 uc009ukh.4 Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks. Chromosome Note=Recruited to replication forks. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C779-1; Sequence=Displayed; Name=2; IsoId=Q8C779-2; Sequence=VSP_021184; DNA binding single-stranded DNA binding replication fork chromosome negative regulation of double-strand break repair via homologous recombination uc009ukh.1 uc009ukh.2 uc009ukh.3 uc009ukh.4 
ENSMUST00000046765.10 Kcnk1 ENSMUST00000046765.10 potassium channel, subfamily K, member 1 (from RefSeq NM_008430.2) ENSMUST00000046765.1 ENSMUST00000046765.2 ENSMUST00000046765.3 ENSMUST00000046765.4 ENSMUST00000046765.5 ENSMUST00000046765.6 ENSMUST00000046765.7 ENSMUST00000046765.8 ENSMUST00000046765.9 KCNK1_MOUSE NM_008430 O08581 Q99L99 uc009nyr.1 uc009nyr.2 uc009nyr.3 uc009nyr.4 uc009nyr.5 uc009nyr.6 Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:16847696, PubMed:22431633, PubMed:24368895). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:9013852, PubMed:24496152). Channel activity is modulated by activation of serotonin receptors (PubMed:24368895). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (PubMed:24496152). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (By similarity). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (PubMed:25406588). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (PubMed:25406588). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (PubMed:24496152). Required for normal ion and water transport in the kidney (PubMed:16025300). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (PubMed:22431633). The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:15540117). Inhibited by quinine, quinidine, barium, and internal acidification. Kinetic parameters: Note=Both activation and channel closure are very rapid. Is not voltage-gated (PubMed:22431633, PubMed:24496152). The relationship between voltage and current is nearly linear (PubMed:22431633, PubMed:24496152). Homodimer; disulfide-linked (PubMed:9013852). Heterodimer with KCNK2; disulfide-linked (PubMed:24496152). In astrocytes, forms mostly heterodimeric potassium channels with KCNK2, with only a minor proportion of functional channels containing homodimeric KCNK1 (By similarity). Interacts with KCNK3 and KCNK9, forming functional heterodimeric channels (By similarity). Interacts with GNG4 (PubMed:24496152). Identified in a complex with PSD and ARF6; interacts only with PSD that is bound to ARF6 (PubMed:15540117). Interacts with UBE2I (By similarity). Cell membrane ulti-pass membrane protein Recycling endosome Apical cell membrane Cytoplasmic vesicle Perikaryon ll projection, dendrite Cell projection Synaptic cell membrane Note=The heterodimer with KCNK2 is detected at the astrocyte cell membrane (PubMed:24496152). Not detected at the astrocyte cell membrane when KCNK2 is absent (PubMed:24496152). Detected on neuronal cell bodies, and to a lesser degree on neuronal cell projections (PubMed:12855359, PubMed:17079103). Detected on hippocampus dentate gyrus granule cell bodies and to a lesser degree on proximal dendrites (PubMed:25406588). Detected at the apical cell membrane in stria vascularis in the cochlea (By similarity). Detected at the apical cell membrane of vestibular dark cells situated between the crista and the utricle in the inner ear (PubMed:12855359). Detected at the apical cell membrane in stria vascularis in the cochlea (PubMed:12855359). Detected at the apical cell membrane in kidney proximal tubule segment S1 and in subapical compartments in segments S1, S2 and S3 (PubMed:16025300). Predominantly in cytoplasmic structures in kidney distal convoluted tubules and collecting ducts (PubMed:16025300). Predominantly in cytoplasmic structures in hippocampus astrocytes; only a minor proportion of the protein is present at the cell membrane (PubMed:24368895). Detected in spiral ganglion neurons (PubMed:17079103). Detected in hippocampus CA1 and CA1 regions and in the molecular layer of the dentate gyrus (PubMed:24368895, PubMed:25406588). Detected on hippocampus astrocytes (PubMed:24368895, PubMed:24496152). Highly expressed in the stria vascularis in the cochlea (PubMed:12855359). Detected in pancreas islet beta cells (PubMed:22431633). Detected in kidney, at brush border membranes in proximal tubules and in cytoplasmic structures in distal convoluted tubules, thick ascending limbs and collecting ducts (at protein level) (PubMed:15540117, PubMed:16025300). Widely expressed. Detected in spiral ganglion cells (PubMed:17079103). Highest expression in brain, kidney, thyroid, salivary gland, adrenal gland, prostate, epididymis, uterus, placenta, colon and jejunum. Moderate expression in eyes, pituitary, pancreas, smooth muscle, testis and ovary. Very low levels in lung, aorta, liver, heart, skeletal muscle, thymus and spleen. In the brain, highest expression in cerebellar granule cells, brainstem, hippocampus and cerebral cortex (PubMed:18222039). Detected at very low levels in the embryonic central nervous system (PubMed:9559671, PubMed:18222039). Detected as early as 7 days post conception (PubMed:9559671). Detected in dorsal root ganglia, hippocampus, olfactory epithelia and intestine at 19 dpc (PubMed:18222039). Expression in the brain increases strongly 3-8 days after birth, a period of intense postnatal brain development (PubMed:9559671, PubMed:18222039). Detected in dentate granule cells; expression levels show no significant variability during postnatal development (PubMed:18222039). Expression is higher in adults than in neonates (PubMed:9559671, PubMed:18222039). Sumoylation is controversial. Sumoylated by UBE2I. Not sumoylated when expressed in xenopus oocytes or mammalian cells. Sumoylation inactivates the channel, but does not interfere with expression at the cell membrane. Sumoylation of a single subunit is sufficient to silence the dimeric channel. Sumoylation of KCNK1 is sufficient to silence heterodimeric channels formed by KCNK1 and KCNK3 or KCNK9. Desumoylated by SENP1; this activates the channel. Desumoylated by SENP1; this strongly increases halothane-mediated activation of heterodimeric channels formed with KCNK9. SENP1 treatment has no effect. No visible phenotype on standard chow, excepting a lower urinary flow rate (PubMed:16025300). Mice appear normal and are fertile (PubMed:24368895). When kept on a low phosphate diet, both wild-type and mutant mice show strongly reduced urinary phosphate secretion. Still, mutant mice display higher fractional urinary phosphate secretion relative to wild-type, leading to reduced inorganic phosphate levels in blood plasma. The impaired phosphate homeostasis seems to be due to indirect effects on the expression of other transporters, such as SLC34A1 and AQP2 (PubMed:16025300). Principal cells from kidney collecting duct are hyperpolarized, display reduced potassium conductance and strongly reduced quinidine-sensitive potassium channel activity (PubMed:16847696). Besides, collecting ducts from mutant mouse kidney display a larger diameter relative to wild- type (PubMed:16847696). Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. inward rectifier potassium channel activity potassium channel activity sodium channel activity cytoplasm endosome plasma membrane integral component of plasma membrane ion transport potassium ion transport membrane integral component of membrane apical plasma membrane potassium ion leak channel activity cell junction stabilization of membrane potential dendrite cytoplasmic vesicle brush border membrane potassium channel complex response to nicotine sodium ion transmembrane transport identical protein binding cell projection perikaryon intracellular membrane-bounded organelle synapse recycling endosome regulation of resting membrane potential potassium ion transmembrane transport inward rectifier potassium channel complex uc009nyr.1 uc009nyr.2 uc009nyr.3 uc009nyr.4 uc009nyr.5 uc009nyr.6 
ENSMUST00000046770.10 Nenf ENSMUST00000046770.10 neuron derived neurotrophic factor (from RefSeq NM_025424.3) ENSMUST00000046770.1 ENSMUST00000046770.2 ENSMUST00000046770.3 ENSMUST00000046770.4 ENSMUST00000046770.5 ENSMUST00000046770.6 ENSMUST00000046770.7 ENSMUST00000046770.8 ENSMUST00000046770.9 NENF_MOUSE NM_025424 Nenf Q5TM91 Q9CQ45 Spuf uc007ecg.1 uc007ecg.2 uc007ecg.3 Acts as a neurotrophic factor in postnatal mature neurons, enhancing neuronal survival (PubMed:15605373, PubMed:31536960). Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocytes (PubMed:16547973). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (PubMed:15605373, PubMed:16547973). Neurotrophic activity is enhanced by binding to heme (PubMed:18056703). Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (PubMed:23576617). Interacts with PINK1 and PARK7. Secreted, extracellular space Mitochondrion Endoplasmic reticulum Note=Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7. In the embryo, expressed most abundantly in brain and spinal cord. Widely expressed in adult tissues including brain, heart, lung and kidney. In brain, expressed in neurons but not in glial cells (PubMed:15605373). In the hypothalamus is expressed primarily in the paraventricular nucleus (PVN), with lower levels of expression in the arcuate nucleus (ARC)(PubMed:23576617). In embryonic cerebral cortex is first weakly detected at 12.5 dpc, and thereafter gradually increased. At 13.5 dpc expression is observed mostly in the preplate. The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residue at position 81. Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). Belongs to the cytochrome b5 family. MAPR subfamily. extracellular region extracellular space nucleus nucleoplasm signal transduction growth factor activity negative regulation of appetite positive regulation of MAPK cascade metal ion binding uc007ecg.1 uc007ecg.2 uc007ecg.3 
ENSMUST00000046777.11 Ift57 ENSMUST00000046777.11 intraflagellar transport 57 (from RefSeq NM_028680.3) ENSMUST00000046777.1 ENSMUST00000046777.10 ENSMUST00000046777.2 ENSMUST00000046777.3 ENSMUST00000046777.4 ENSMUST00000046777.5 ENSMUST00000046777.6 ENSMUST00000046777.7 ENSMUST00000046777.8 ENSMUST00000046777.9 Hippi IFT57_MOUSE NM_028680 Q8BXG3 Q924M2 Q9CUS6 uc007zkf.1 uc007zkf.2 uc007zkf.3 Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (PubMed:19253336, PubMed:23810713). Interacts with IFT20 (PubMed:12821668). Interacts with IFT88 (PubMed:11062270, PubMed:19253336, PubMed:23810713). Interacts with IFT80, IFT-81, IFT74, IFT172, IFT70B and KIF17 (PubMed:23810713). Interacts with BLOC1S2 (PubMed:18188704). Interacts with RYBP (PubMed:17874297). Interacts with HOMER1; the interaction possibly prevents the pro-apoptotic effects of IFT57 (PubMed:17107665). Interacts with HIP1 (By similarity). In normal conditions, it poorly interacts with HIP1, HIP1 being strongly associated with HTT (By similarity). However, in mutant HTT proteins with a long poly-Gln region, interaction between HTT and HIP1 is inhibited, promoting the interaction between HIP1 and IFT57, leading to apoptosis (By similarity). Interacts with BFAR (By similarity). Interacts with TTC25 (PubMed:25860617). Interacts with USH1G (By similarity). Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus. Note=Concentrates within the inner segment of cilia. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BXG3-1; Sequence=Displayed; Name=2; IsoId=Q8BXG3-2; Sequence=VSP_032843; Present in retina and testis. In brain, it is present in the cortex, striatum, globus pallidus, hypothalamus and cerebellum. Present at high level in neurons and neuropil throughout the brain (at protein level). Expressed in hippocampal neurons, where it colocalizes with HOMER1 at postsynaptic regions. Ubiquitous through the epiblast. Expression is detected in mesoderm and most strongly in ectoderm, but not in endoderm. Highly expressed in the region of the node, a depression at the surface of the embryo proposed to have a role in left-right axis patterning. At 8.5 dpc, it is widely expressed except in the heart. Stronger expression is observed in the anterior midline, the forebrain and the somites. Strong expression remains in the forebrain at 9.5 dpc and 10.5 dpc and extends to all regions of the neural tube. At those stages, high expression is also found in the branchial arches and in the limb buds. Embryo section at 9.5 dpc also shows expression throughout the neural tube and the mesoderm, but not in the surface ectoderm. The strongest expression is observed on the luminal edge of the neural tube and in the ventral foregut. The pseudo DED region (pDED) mediates the interaction with HIP1. Mice show randomization of the embryo turning process and heart looping, which are hallmarks of defective left-right (LR) axis patterning. Motile monocilia normally present at the surface of the embryonic node, and proposed to initiate the break in LR symmetry, are absent. Furthermore, defects in central nervous system development are observed. The Sonic hedgehog (Shh) pathway is down- regulated in the neural tube, resulting in failure to establish ventral neural cell fate. Belongs to the IFT57 family. neural tube closure heart looping DNA binding protein binding cytoplasm Golgi apparatus centrosome cytoskeleton cilium axoneme apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process smoothened signaling pathway intraciliary transport particle B photoreceptor connecting cilium ciliary basal body intraciliary transport regulation of apoptotic process cell projection dendrite terminus motile cilium assembly negative regulation of epithelial cell proliferation left/right pattern formation non-motile cilium assembly uc007zkf.1 uc007zkf.2 uc007zkf.3 
ENSMUST00000046792.9 Olfml2b ENSMUST00000046792.9 olfactomedin-like 2B, transcript variant 13 (from RefSeq NR_175832.1) ENSMUST00000046792.1 ENSMUST00000046792.2 ENSMUST00000046792.3 ENSMUST00000046792.4 ENSMUST00000046792.5 ENSMUST00000046792.6 ENSMUST00000046792.7 ENSMUST00000046792.8 NR_175832 OLM2B_MOUSE Q3T9I5 Q3V1G4 Q8C106 Q8R3B2 uc007dmi.1 uc007dmi.2 uc007dmi.3 Homodimer. Binds to heparin and chondroitin sulfate E. Secreted Broadly expressed. Within the eye, present in ganglion cells, inner nuclear layers, inner segment of photoreceptor layers and retinal pigment epithelium (at protein level). O-glycosylated and N-glycosylated. Sequence=BAE43035.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE43035.1; Type=Frameshift; Evidence=; extracellular region extracellular space extracellular matrix organization extracellular matrix extracellular matrix binding uc007dmi.1 uc007dmi.2 uc007dmi.3 
ENSMUST00000046807.7 Slc16a9 ENSMUST00000046807.7 solute carrier family 16 (monocarboxylic acid transporters), member 9 (from RefSeq NM_025807.3) ENSMUST00000046807.1 ENSMUST00000046807.2 ENSMUST00000046807.3 ENSMUST00000046807.4 ENSMUST00000046807.5 ENSMUST00000046807.6 MOT9_MOUSE Mct9 NM_025807 Q0P652 Q7TM99 uc007fnq.1 uc007fnq.2 uc007fnq.3 Extracellular pH-and Na(+)-sensitive low-affinity creatine transporter. Functions also as a pH-independent carnitine efflux transporter. Reaction=creatine(in) = creatine(out); Xref=Rhea:RHEA:73043, ChEBI:CHEBI:57947; Evidence=; Reaction=(R)-carnitine(in) = (R)-carnitine(out); Xref=Rhea:RHEA:34959, ChEBI:CHEBI:16347; Evidence=; Cell membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. Sequence=AAH34205.1; Type=Frameshift; Evidence=; plasma membrane integral component of plasma membrane monocarboxylic acid transmembrane transporter activity symporter activity monocarboxylic acid transport membrane integral component of membrane urate metabolic process transmembrane transport uc007fnq.1 uc007fnq.2 uc007fnq.3 
ENSMUST00000046835.14 Fnip1 ENSMUST00000046835.14 folliculin interacting protein 1 (from RefSeq NM_173753.4) ENSMUST00000046835.1 ENSMUST00000046835.10 ENSMUST00000046835.11 ENSMUST00000046835.12 ENSMUST00000046835.13 ENSMUST00000046835.2 ENSMUST00000046835.3 ENSMUST00000046835.4 ENSMUST00000046835.5 ENSMUST00000046835.6 ENSMUST00000046835.7 ENSMUST00000046835.8 ENSMUST00000046835.9 FNIP1_MOUSE Fnip1 Kiaa1961 NM_173753 Q68FD7 Q80T72 Q8BQM0 uc007ixx.1 uc007ixx.2 uc007ixx.3 uc007ixx.4 Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:23582324). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (By similarity). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase- activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase- activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (By similarity). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (By similarity). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (By similarity). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (By similarity). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (PubMed:32941802). Required for B-cell development (PubMed:22709692, PubMed:27303042). Homodimer and homomultimer (By similarity). Heterodimer and heteromultimer with FNIP2 (By similarity). Interacts with FLCN (via C- terminus) (By similarity). Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator (By similarity). Interacts with HSPCA and with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK) (By similarity). Phosphorylated FLCN and AMPK are preferentially bound (By similarity). Interacts with HSP70, STIP1, PTGES3, CDC37, BRAF, GCR and CDK4 (By similarity). Interacts with HSP90AA1; the interaction inhibits HSP90AA1 ATPase activity (By similarity). Interacts with ATP2A2 (PubMed:35412553). Q68FD7; Q8QZS3: Flcn; NbExp=3; IntAct=EBI-6911068, EBI-6911093; Lysosome membrane Cytoplasm, cytosol Note=Localizes to lysosome membrane in amino acid-depleted conditions and relocalizes to the cytosol upon refeeding. Colocalizes with FLCN in the cytoplasm. The KY-finger orients the Cys degron for ubiquitination by the CRL2(FEM1B) complex. Phosphorylated by AMPK in response to energetic stress (PubMed:37079666). Phosphorylation by AMPK in response to mitochondrial damage promotes inactivation of the non-canonical mTORC1 signaling, nuclear translocation of TFEB and TFE3, inducing transcription of lysosomal or autophagy genes (PubMed:37079666). Sequential phosphorylation by CK2 promotes its gradual interaction with HSP90AA1/Hsp90 (By similarity). Priming phosphorylation at Ser-937 is followed by relay phosphorylation at Ser-938, Ser-940, Ser-945 and Ser- 947, promoting its gradual interaction with HSP90AA1/Hsp90 (By similarity). This leads to incremental inhibition of HSP90AA1/Hsp90 ATPase activity and gradual activation of both kinase and non-kinase clients (By similarity). Dephosphorylated by protein phosphatase 5 (PP5), promoting glycosylation by OGT (By similarity). GlcNAcylation at Ser-937 by OGT following dephosphorylation by protein phosphatase 5 (PP5) promotes ubiquitination and degradation by the proteasome. Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties at Lys-1118 following glycosylation by OGT, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the CRL2(FEM1B) complex in response to reductive stress: reductive stress causes reduction of the conserved Cys degron in FNIP1, followed by zinc- binding, zinc acting as a molecular glue for recognition by the CRL2(FEM1B) complex (PubMed:32941802, PubMed:34562363). Ubiquitination leads to FNIP1 degradation, and activation of mitochondria to recalibrate reactive oxygen species (ROS) (PubMed:32941802, PubMed:34562363). Oxidation of the Cys degron in normal conditions promotes its stabilization by preventing recognition and ubiquitination by the CRL2(FEM1B) complex. Mice develop normally but display defects in B- cell development independent of mTOR activity (PubMed:22709692, PubMed:27303042). B-cell development defects result from rapid caspase- induced pre-B cell death (PubMed:22709692). Heterozygous mice show caused a loss of marginal zone B-cells (PubMed:27303042). Mice also develop cardiomyopathy characterized by left ventricular hypertrophy and elevated AMPK activity (PubMed:25775561, PubMed:27303042). Mice do not show strong susceptibility to kidney neoplasia (PubMed:22709692, PubMed:25775561). They however display slightly enlarged kidney size and slightly increased renal cyst formation, characterized by decreased AMPK activation, increased mTOR activation and metabolic hyperactivation (PubMed:29897930). Conditional deletion in adipocytes promotes browning of white adipose tissue (PubMed:35412553). Mice lacking both Fnip1 and Fnip2 show enlarged polycystic kidneys (PubMed:25775561). Belongs to the FNIP family. Sequence=BAC33163.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC65856.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter regulation of protein phosphorylation positive regulation of protein phosphorylation immature B cell differentiation positive regulation of B cell apoptotic process guanyl-nucleotide exchange factor activity protein binding cytoplasm cellular response to starvation negative regulation of mitochondrion organization positive regulation of protein complex assembly TOR signaling negative regulation of TOR signaling positive regulation of peptidyl-serine phosphorylation ATPase inhibitor activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic process chaperone binding negative regulation of TORC1 signaling regulation of pro-B cell differentiation uc007ixx.1 uc007ixx.2 uc007ixx.3 uc007ixx.4 
ENSMUST00000046839.10 Gfer ENSMUST00000046839.10 growth factor, augmenter of liver regeneration, transcript variant 1 (from RefSeq NM_023040.4) ALR_MOUSE Alr ENSMUST00000046839.1 ENSMUST00000046839.2 ENSMUST00000046839.3 ENSMUST00000046839.4 ENSMUST00000046839.5 ENSMUST00000046839.6 ENSMUST00000046839.7 ENSMUST00000046839.8 ENSMUST00000046839.9 MNCb-0663 NM_023040 P56213 Q8CIF8 Q9JJE6 uc008axr.1 uc008axr.2 uc008axr.3 FAD-dependent sulfhydryl oxidase that regenerates the redox- active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen (By similarity). Reaction=O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'; Xref=Rhea:RHEA:17357, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:16520, ChEBI:CHEBI:17412; EC=1.8.3.2; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Homodimer; disulfide-linked. Interacts with CHCHD4/MIA40. Mitochondrion intermembrane space Mitochondrion Preferentially expressed in the liver and in testis. Sequence=AAD36987.1; Type=Erroneous initiation; Evidence=; extracellular space mitochondrion mitochondrial intermembrane space cytosol signal transduction growth factor activity protein disulfide oxidoreductase activity oxidoreductase activity flavin-linked sulfhydryl oxidase activity thiol oxidase activity negative regulation of apoptotic process negative regulation of natural killer cell mediated cytotoxicity flavin adenine dinucleotide binding oxidation-reduction process liver regeneration negative regulation of oxidative stress-induced neuron death positive regulation of DNA biosynthetic process uc008axr.1 uc008axr.2 uc008axr.3 
ENSMUST00000046856.14 Chn2 ENSMUST00000046856.14 chimerin 2, transcript variant 2 (from RefSeq NM_001163640.1) Chn2 ENSMUST00000046856.1 ENSMUST00000046856.10 ENSMUST00000046856.11 ENSMUST00000046856.12 ENSMUST00000046856.13 ENSMUST00000046856.2 ENSMUST00000046856.3 ENSMUST00000046856.4 ENSMUST00000046856.5 ENSMUST00000046856.6 ENSMUST00000046856.7 ENSMUST00000046856.8 ENSMUST00000046856.9 NM_001163640 Q3V2R3 Q3V2R3_MOUSE uc009bzo.1 uc009bzo.2 uc009bzo.3 uc009bzo.4 GTPase-activating protein for p21-rac. GTPase activator activity signal transduction intracellular signal transduction positive regulation of GTPase activity metal ion binding regulation of small GTPase mediated signal transduction uc009bzo.1 uc009bzo.2 uc009bzo.3 uc009bzo.4 
ENSMUST00000046863.12 Hsd3b7 ENSMUST00000046863.12 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7, transcript variant 1 (from RefSeq NM_133943.3) 3BHS7_MOUSE A2RTR5 ENSMUST00000046863.1 ENSMUST00000046863.10 ENSMUST00000046863.11 ENSMUST00000046863.2 ENSMUST00000046863.3 ENSMUST00000046863.4 ENSMUST00000046863.5 ENSMUST00000046863.6 ENSMUST00000046863.7 ENSMUST00000046863.8 ENSMUST00000046863.9 Hsd3b7 NM_133943 Q9EQC1 uc009jww.1 uc009jww.2 uc009jww.3 The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (PubMed:22999953). Reaction=7alpha-hydroxycholesterol + NAD(+) = 7alpha-hydroxycholest-4- en-3-one + H(+) + NADH; Xref=Rhea:RHEA:11896, ChEBI:CHEBI:15378, ChEBI:CHEBI:17500, ChEBI:CHEBI:17899, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.181; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11897; Evidence=; Reaction=7alpha,25-dihydroxycholesterol + NAD(+) = 7alpha,25-dihydroxy- 4-cholesten-3-one + H(+) + NADH; Xref=Rhea:RHEA:47156, ChEBI:CHEBI:15378, ChEBI:CHEBI:37623, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:81013; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47157; Evidence=; Reaction=(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) = (25R)- 7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH; Xref=Rhea:RHEA:47180, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76592, ChEBI:CHEBI:87476; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47181; Evidence=; Reaction=(24S)-7alpha-dihydroxycholesterol + NAD(+) = (24S)-7alpha,24- dihydroxycholest-4-en-3-one + H(+) + NADH; Xref=Rhea:RHEA:47200, ChEBI:CHEBI:15378, ChEBI:CHEBI:37640, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:63838; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47201; Evidence=; Lipid metabolism; steroid biosynthesis. Endoplasmic reticulum membrane; Multi-pass membrane protein. Predominantly expressed in liver. Belongs to the 3-beta-HSD family. regulation of cell growth 3-beta-hydroxy-delta5-steroid dehydrogenase activity endoplasmic reticulum endoplasmic reticulum membrane lipid particle steroid biosynthetic process cholesterol catabolic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor B cell chemotaxis intracellular membrane-bounded organelle cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity oxidation-reduction process uc009jww.1 uc009jww.2 uc009jww.3 
ENSMUST00000046864.14 Vav3 ENSMUST00000046864.14 vav 3 oncogene, transcript variant 1 (from RefSeq NM_020505.2) A2CFD7 ENSMUST00000046864.1 ENSMUST00000046864.10 ENSMUST00000046864.11 ENSMUST00000046864.12 ENSMUST00000046864.13 ENSMUST00000046864.2 ENSMUST00000046864.3 ENSMUST00000046864.4 ENSMUST00000046864.5 ENSMUST00000046864.6 ENSMUST00000046864.7 ENSMUST00000046864.8 ENSMUST00000046864.9 NM_020505 Q7TS85 Q8BRV2 Q8CCF5 Q8R076 Q9JLS6 Q9R0C8 VAV3_MOUSE uc008rag.1 uc008rag.2 uc008rag.3 Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta- 1-mediated adhesion. Interacts with the PH domain of APS. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation (By similarity). Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Event=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=1; Synonyms=Alpha; IsoId=Q9R0C8-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q9R0C8-2; Sequence=Not described; Name=3; Synonyms=VAV3.1; IsoId=Q9R0C8-3; Sequence=VSP_042360, VSP_042361; Name=4; IsoId=Q9R0C8-4; Sequence=VSP_042362, VSP_042363; Abundantly expressed in osteoclasts and mature osteoblasts. Also expressed in bone marrow macrophages (at protein level):. Phosphorylated. Phosphorylation can be mediated by ROS1 (By similarity). In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1. Mutant mice exhibit increased bone density, due to diminished bone resorption, including following parathyroid hormone treatment. This phenotype is due to defective terminal osteoclast differentiation. They also show a delayed wound repair program, characterized by a deficit in macrophage emigration to the wound, a reduced myofibroblast-dependent wound contraction and a diminished neovascularization in the restoration tissue. [Isoform 3]: Produced by alternative promoter usage. [Isoform 4]: Produced by alternative splicing. angiogenesis guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding protein binding cytoplasm plasma membrane vesicle fusion cellular response to DNA damage stimulus integrin-mediated signaling pathway small GTPase mediated signal transduction regulation of cell size cell migration cell projection assembly lamellipodium assembly neutrophil chemotaxis Rac guanyl-nucleotide exchange factor activity positive regulation of B cell proliferation regulation of Rho protein signal transduction intracellular signal transduction response to drug regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity positive regulation of cell adhesion metal ion binding B cell receptor signaling pathway uc008rag.1 uc008rag.2 uc008rag.3 
ENSMUST00000046869.11 Fbxw4 ENSMUST00000046869.11 F-box and WD-40 domain protein 4, transcript variant 2 (from RefSeq NR_182263.1) ENSMUST00000046869.1 ENSMUST00000046869.10 ENSMUST00000046869.2 ENSMUST00000046869.3 ENSMUST00000046869.4 ENSMUST00000046869.5 ENSMUST00000046869.6 ENSMUST00000046869.7 ENSMUST00000046869.8 ENSMUST00000046869.9 FBXW4_MOUSE Fbw4 NR_182263 Q9JMJ2 Q9QXW3 uc008hrf.1 uc008hrf.2 uc008hrf.3 Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (Probable). Interacts with POUF51 (PubMed:29153991). Sequence=AAF22827.1; Type=Frameshift; Evidence=; positive regulation of mesenchymal cell proliferation multicellular organism development Wnt signaling pathway SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process embryonic digit morphogenesis cartilage development limb development uc008hrf.1 uc008hrf.2 uc008hrf.3 
ENSMUST00000046875.14 Uggt1 ENSMUST00000046875.14 UDP-glucose glycoprotein glucosyltransferase 1 (from RefSeq NM_198899.2) E9QQ49 ENSMUST00000046875.1 ENSMUST00000046875.10 ENSMUST00000046875.11 ENSMUST00000046875.12 ENSMUST00000046875.13 ENSMUST00000046875.2 ENSMUST00000046875.3 ENSMUST00000046875.4 ENSMUST00000046875.5 ENSMUST00000046875.6 ENSMUST00000046875.7 ENSMUST00000046875.8 ENSMUST00000046875.9 Gt NM_198899 Q6NV70 Q6P5E4 UGGG1_MOUSE Ugcgl1 Uggt Ugt1 Ugtr uc007app.1 uc007app.2 uc007app.3 uc007app.4 Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity). Reaction=N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man- (1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)- alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D- GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = H(+) + N(4)- (alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- (1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:61304, Rhea:RHEA-COMP:14356, Rhea:RHEA-COMP:14357, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885, ChEBI:CHEBI:59080, ChEBI:CHEBI:139493; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Monomer as well as in a tight complex with SELENOF (PubMed:11278576). Interacts with METTL23 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (By similarity). Endoplasmic reticulum lumen Endoplasmic reticulum-Golgi intermediate compartment The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects. Belongs to the glycosyltransferase 8 family. UDP-glucose:glycoprotein glucosyltransferase activity protein binding endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum-Golgi intermediate compartment protein glycosylation transferase activity transferase activity, transferring glycosyl groups protein N-linked glycosylation via asparagine macromolecular complex unfolded protein binding ER-associated misfolded protein catabolic process UDP-glucosylation uc007app.1 uc007app.2 uc007app.3 uc007app.4 
ENSMUST00000046890.12 Rassf7 ENSMUST00000046890.12 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 (from RefSeq NM_025886.3) ENSMUST00000046890.1 ENSMUST00000046890.10 ENSMUST00000046890.11 ENSMUST00000046890.2 ENSMUST00000046890.3 ENSMUST00000046890.4 ENSMUST00000046890.5 ENSMUST00000046890.6 ENSMUST00000046890.7 ENSMUST00000046890.8 ENSMUST00000046890.9 NM_025886 Q9DD19 RASF7_MOUSE uc009kka.1 uc009kka.2 Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization (By similarity). Interacts with MAP2K7 and GTP-bound NRAS. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with gamma-tubulin. Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli. molecular_function cytoplasm microtubule organizing center cytoskeleton apoptotic process signal transduction biological_process regulation of microtubule cytoskeleton organization uc009kka.1 uc009kka.2 
ENSMUST00000046891.6 Ptger2 ENSMUST00000046891.6 prostaglandin E receptor 2 (subtype EP2) (from RefSeq NM_008964.4) ENSMUST00000046891.1 ENSMUST00000046891.2 ENSMUST00000046891.3 ENSMUST00000046891.4 ENSMUST00000046891.5 NM_008964 PE2R2_MOUSE Ptgerep2 Q62053 uc007tgd.1 uc007tgd.2 uc007tgd.3 uc007tgd.4 Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity prostaglandin E receptor activity plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane response to lipopolysaccharide response to progesterone regulation of cell proliferation cellular response to prostaglandin E stimulus positive regulation of gastric mucosal blood circulation uc007tgd.1 uc007tgd.2 uc007tgd.3 uc007tgd.4 
ENSMUST00000046892.10 Cplx1 ENSMUST00000046892.10 complexin 1 (from RefSeq NM_007756.3) CPLX1_MOUSE ENSMUST00000046892.1 ENSMUST00000046892.2 ENSMUST00000046892.3 ENSMUST00000046892.4 ENSMUST00000046892.5 ENSMUST00000046892.6 ENSMUST00000046892.7 ENSMUST00000046892.8 ENSMUST00000046892.9 NM_007756 O09057 O09142 P63040 Q3UYB3 Q64276 Q91WJ3 uc008yof.1 uc008yof.2 uc008yof.3 uc008yof.4 Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:23345244). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:23345244). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior (PubMed:15126625, PubMed:16000319). Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A. Cytoplasm, cytosol rikaryon Presynapse Note=Enriched at synaptic- releasing sites in mature neurons. Nervous system, and pancreatic islet cells. Present in many brain regions, including hippocampus and cerebellum. In the retina, present at conventional amacrine cell synapses (at protein level). In the brain, expression starts at P6 and increases to reach a plateau at P20. Mice have no obvious brain abnormality, but suffer from severe ataxia with dystonia starting from P7. Adult mice lacking Cplx1 are not capable of coordinated running or swimming and exhibit pronounced resting tremor. They also fail to habituate to confinement and have reduced exploration abilities in open field. Belongs to the complexin/synaphin family. SNARE binding neurotransmitter transporter activity cytoplasm cytosol neurotransmitter transport exocytosis synaptic vesicle exocytosis syntaxin-1 binding syntaxin binding insulin secretion dendrite SNARE complex regulation of synaptic vesicle fusion to presynaptic membrane macromolecular complex neuronal cell body terminal bouton calyx of Held synapse regulation of neurotransmitter secretion synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex presynapse postsynapse exocytic insertion of neurotransmitter receptor to postsynaptic membrane glutamatergic synapse vesicle-mediated transport in synapse uc008yof.1 uc008yof.2 uc008yof.3 uc008yof.4 
ENSMUST00000046897.13 Trim14 ENSMUST00000046897.13 tripartite motif-containing 14 (from RefSeq NM_029077.4) B1AVH3 ENSMUST00000046897.1 ENSMUST00000046897.10 ENSMUST00000046897.11 ENSMUST00000046897.12 ENSMUST00000046897.2 ENSMUST00000046897.3 ENSMUST00000046897.4 ENSMUST00000046897.5 ENSMUST00000046897.6 ENSMUST00000046897.7 ENSMUST00000046897.8 ENSMUST00000046897.9 Kiaa0129 NM_029077 Pub Q6A0C3 Q762I6 Q8BVW3 Q9D3G8 TRI14_MOUSE uc008stx.1 uc008stx.2 uc008stx.3 uc008stx.4 Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593). Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (PubMed:14592421). Inhibits also OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3. Mechanistically, recruits USP14 to remove the 'Lys-63'-linked ubiquitination of KDM4D, preventing its recognition by OPTN and subsequent degradation (PubMed:35145029). Plays an essential role in the innate immune defense against viruses and bacteria. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS- induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593). Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (PubMed:14592421). Interacts with MAVS. Interacts with WRNIP1 and PPP6C; these interactions positively regulate the RIG-I signaling pathway. Interacts with CGAS; this interaction stabilizes CGAS and promotes type I interferon production. Interacts with USP14; this interaction mediates the cleavage of 'Lys-48'-linked ubiquitination of CGAS (By similarity). Interacts with TBK1 (By similarity). Interacts with SPI1 (PubMed:14592421). Interacts with KDM4D and USP14 (By similarity). Mitochondrion outer membrane Cytoplasmic vesicle, phagosome Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BVW3-1; Sequence=Displayed; Name=2; IsoId=Q8BVW3-2; Sequence=VSP_012055, VSP_012056; Name=3; IsoId=Q8BVW3-3; Sequence=VSP_012053, VSP_012054; Expressed with high level in spleen, thymus, liver and testis. Expressed with low level in the brain, kidney, and skeletal muscle. Expressed in various differentiation stages of B-lymphocytes. The B-box zinc finger is responsible for inhibition of SPI1- mediated transcriptional activation. Ubiquitinated. Undergoes 'Lys-63'-linked polyubiquitination; this modification allows IKBKG/NEMO recruitment to MAVS. Undergoes 'Lys-48'- linked polyubiquitination by RNF125; this modification mediates its degradation via the ubiquitin-proteasome pathway. Knockout mice have an impaired herpes simplex virus type 1 (HSV-1)-triggered antiviral responses and become highly susceptible to lethal HSV-1 infection. n addition, TRIM14-deficient mice are more resistant to inflammation compared to WT (PubMed:35145029). Belongs to the TRIM/RBCC family. Sequence=BAD32173.1; Type=Erroneous initiation; Evidence=; immune system process molecular_function cytoplasm mitochondrion mitochondrial outer membrane zinc ion binding membrane negative regulation of viral transcription innate immune response metal ion binding positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity uc008stx.1 uc008stx.2 uc008stx.3 uc008stx.4 
ENSMUST00000046903.6 Trim7 ENSMUST00000046903.6 tripartite motif-containing 7, transcript variant 2 (from RefSeq NM_001347446.1) ENSMUST00000046903.1 ENSMUST00000046903.2 ENSMUST00000046903.3 ENSMUST00000046903.4 ENSMUST00000046903.5 NM_001347446 Q5NCB7 Q5NCB7_MOUSE Trim7 uc057kku.1 uc057kku.2 uc057kku.3 Protein modification; protein ubiquitination. nucleus cytoplasm zinc ion binding metal ion binding uc057kku.1 uc057kku.2 uc057kku.3 
ENSMUST00000046916.9 Ckap2 ENSMUST00000046916.9 cytoskeleton associated protein 2 (from RefSeq NM_001004140.2) A6H5W7 CKAP2_MOUSE Ckap2 ENSMUST00000046916.1 ENSMUST00000046916.2 ENSMUST00000046916.3 ENSMUST00000046916.4 ENSMUST00000046916.5 ENSMUST00000046916.6 ENSMUST00000046916.7 ENSMUST00000046916.8 NM_001004140 Q3V1H1 Q66LN2 Q8BSF0 uc009lcs.1 uc009lcs.2 uc009lcs.3 uc009lcs.4 Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53-dependent manner. Associates with alpha- and beta-tubulins. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules (By similarity). By constitutively activated RET proteins. By p53/TP53. Belongs to the CKAP2 family. Sequence=BAC28747.1; Type=Erroneous initiation; Evidence=; mitotic cytokinesis spindle pole molecular_function cytoplasm centrosome spindle cytosol cytoskeleton microtubule cytoplasmic microtubule apoptotic process negative regulation of microtubule depolymerization cell cycle microtubule cytoskeleton positive regulation of transcription from RNA polymerase II promoter uc009lcs.1 uc009lcs.2 uc009lcs.3 uc009lcs.4 
ENSMUST00000046929.7 Usp31 ENSMUST00000046929.7 ubiquitin specific peptidase 31 (from RefSeq NM_001033173.2) E9Q6Y8 E9Q6Y8_MOUSE ENSMUST00000046929.1 ENSMUST00000046929.2 ENSMUST00000046929.3 ENSMUST00000046929.4 ENSMUST00000046929.5 ENSMUST00000046929.6 NM_001033173 Usp31 uc012ftd.1 uc012ftd.2 Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; thiol-dependent ubiquitin-specific protease activity nucleus ubiquitin-dependent protein catabolic process protein deubiquitination thiol-dependent ubiquitinyl hydrolase activity uc012ftd.1 uc012ftd.2 
ENSMUST00000046937.4 Tssk1 ENSMUST00000046937.4 testis-specific serine kinase 1 (from RefSeq NM_009435.2) ENSMUST00000046937.1 ENSMUST00000046937.2 ENSMUST00000046937.3 NM_009435 Q61241 Q80YU1 Stk22a TSSK1_MOUSE Tssk1b uc007ymk.1 uc007ymk.2 uc007ymk.3 Testis-specific serine/threonine-protein kinase required during spermatid development (PubMed:20053632, PubMed:23599433). Phosphorylates 'Ser-281' of TSKS (PubMed:20053632). Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm (PubMed:20053632). During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body (PubMed:20053632). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Mg(2+) and Mn(2+) were both present in the kinase buffer but Mg(2+) is likely to be the in vivo cofactor. ; Activated by phosphorylation on Thr-174, potentially by autophosphorylation. Interacts with TSSK2 (PubMed:10781952). Interacts with HSP90; this interaction stabilizes TSSK1 (PubMed:23599433). Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=In spermatozoa, present in the sperm head and in the flagellum. Testis-specific. Expressed only in postmeiotic spermatids at the final stages of cytodifferentiation in the seminiferous tubules (at protein level). Not detected in released sperms in the lumen of the seminiferous tubules and the epididymis. Autophosphorylated. Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation. Male mice lacking Tssk1b and Tssk2 are sterile due to haploinsufficiency. chimeras show failure to form elongated spermatids, apoptosis of spermatocytes and spermatids, and the appearance of numerous round cells in the epididymal lumen. Elongating spermatids possess a collapsed mitochondrial sheath. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding magnesium ion binding acrosomal vesicle protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm cilium protein phosphorylation multicellular organism development spermatogenesis spermatid development kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation cell differentiation cytoplasmic vesicle motile cilium intracellular signal transduction cell projection macromolecular complex binding metal ion binding uc007ymk.1 uc007ymk.2 uc007ymk.3 
ENSMUST00000046941.8 Rnf122 ENSMUST00000046941.8 ring finger protein 122, transcript variant 4 (from RefSeq NM_175136.3) A0A0R4J0G8 A0A0R4J0G8_MOUSE ENSMUST00000046941.1 ENSMUST00000046941.2 ENSMUST00000046941.3 ENSMUST00000046941.4 ENSMUST00000046941.5 ENSMUST00000046941.6 ENSMUST00000046941.7 NM_175136 Rnf122 uc009ljd.1 uc009ljd.2 uc009ljd.3 uc009ljd.4 cytoplasm negative regulation of mitochondrial membrane potential membrane integral component of membrane positive regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process protein autoubiquitination ubiquitin protein ligase activity uc009ljd.1 uc009ljd.2 uc009ljd.3 uc009ljd.4 
ENSMUST00000046944.6 D630003M21Rik ENSMUST00000046944.6 RIKEN cDNA D630003M21 gene, transcript variant 1 (from RefSeq NM_177657.5) A2AC61 B2RQJ6 ENSMUST00000046944.1 ENSMUST00000046944.2 ENSMUST00000046944.3 ENSMUST00000046944.4 ENSMUST00000046944.5 K1755_MOUSE NM_177657 Q8BWG4 uc008npv.1 uc008npv.2 uc008npv.3 uc008npv.4 uc008npv.5 molecular_function cellular_component biological_process uc008npv.1 uc008npv.2 uc008npv.3 uc008npv.4 uc008npv.5 
ENSMUST00000046945.13 Palm ENSMUST00000046945.13 paralemmin, transcript variant 1 (from RefSeq NM_023128.4) ENSMUST00000046945.1 ENSMUST00000046945.10 ENSMUST00000046945.11 ENSMUST00000046945.12 ENSMUST00000046945.2 ENSMUST00000046945.3 ENSMUST00000046945.4 ENSMUST00000046945.5 ENSMUST00000046945.6 ENSMUST00000046945.7 ENSMUST00000046945.8 ENSMUST00000046945.9 NM_023128 PALM_MOUSE Q9Z0P3 Q9Z0P4 uc007fzw.1 uc007fzw.2 uc007fzw.3 Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. Interacts with dopamine receptor DRD3. Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, axon Cell projection, dendrite Cell projection, dendritic spine. Basolateral cell membrane ; Lipid-anchor Apicolateral cell membrane ; Lipid-anchor Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Paralemmin-L; IsoId=Q9Z0P4-1; Sequence=Displayed; Name=2; Synonyms=Paralemmin-S; IsoId=Q9Z0P4-2; Sequence=VSP_003919; Expression is highest in brain, intermediate in adrenal gland and kidney, and much lower or undetectable in other tissues. Isoform 1 is the predominant isoform in most tissues except brain and kidney where isoform 2 predominates. In brain, expression is highest in neonates and declines to approximately 50% in adults. Isoform 2 is the predominant isoform in neonates with isoform 1 being barely detectable at this stage. Levels of isoform 1 increase with age, with the most pronounced increase between postnatal days 10 and 20. [Isoform 2]: Mutagenesis of Cys-333, Cys-335 and Cys-336 to Ser inhibit filopodia and spines induction and synapse maturation. Belongs to the paralemmin family. nucleus cytoplasm plasma membrane cytoskeleton organization adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity protein localization regulation of cell shape postsynaptic density membrane basolateral plasma membrane apicolateral plasma membrane filopodium axon dendrite filopodium membrane D3 dopamine receptor binding dendrite membrane dendritic spine membrane cell projection dendritic spine intracellular membrane-bounded organelle neuron spine positive regulation of filopodium assembly synapse maturation negative regulation of dopamine receptor signaling pathway positive regulation of dendritic spine development cellular response to electrical stimulus protein localization to plasma membrane uc007fzw.1 uc007fzw.2 uc007fzw.3 
ENSMUST00000046948.10 Cables1 ENSMUST00000046948.10 CDK5 and Abl enzyme substrate 1, transcript variant 2 (from RefSeq NM_022021.3) CABL1_MOUSE Cables E9QNI6 ENSMUST00000046948.1 ENSMUST00000046948.2 ENSMUST00000046948.3 ENSMUST00000046948.4 ENSMUST00000046948.5 ENSMUST00000046948.6 ENSMUST00000046948.7 ENSMUST00000046948.8 ENSMUST00000046948.9 NM_022021 Q9EPR8 Q9ESJ1 uc012azi.1 uc012azi.2 uc012azi.3 Cyclin-dependent kinase binding protein. Enhances cyclin- dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). Found in a complex with p53/TP53 (By similarity). Found in a number of complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, CDK17, CCNA1, CCNE1 and TP73. Interacts with CDK2, CDK3, CDK5, ABL1 and TDRD7. Q9ESJ1; O88898: Tp63; NbExp=2; IntAct=EBI-604411, EBI-2338025; Q9ESJ1; P04637: TP53; Xeno; NbExp=3; IntAct=EBI-604411, EBI-366083; Q9ESJ1; O15350: TP73; Xeno; NbExp=3; IntAct=EBI-604411, EBI-389606; Nucleus. Cytoplasm. Cell projection, growth cone. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons. Ubiquitous. Expressed in postnatal day 1 (P1), in postmitotic neurons of the subplate, cortex (V/VI) and marginal zone; in postnatal day 7 (P7), in all layers of the cerebral cortex and in the CA1 and CA2 regions of the hippocampus (at protein level). Highly expressed in brain, kidney, liver and lung. Expressed in embryo at 15 dpc and strongly expressed in postmitotic neurons of the subplate, cortical plate, subventrical and marginal zones at 18 dpc (at protein level). Expressed in embryo at 7 dpc onwards. Phosphorylated on Ser-274 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3. Belongs to the cyclin family. PubMed:10896159 demonstrated that CABLES1 is not associated with CDK3. G1/S transition of mitotic cell cycle protein binding nucleus nucleoplasm cytoplasm cytosol cell cycle nervous system development growth cone cell projection cell division regulation of cell cycle uc012azi.1 uc012azi.2 uc012azi.3 
ENSMUST00000046951.10 Pak1ip1 ENSMUST00000046951.10 PAK1 interacting protein 1 (from RefSeq NM_026550.3) ENSMUST00000046951.1 ENSMUST00000046951.2 ENSMUST00000046951.3 ENSMUST00000046951.4 ENSMUST00000046951.5 ENSMUST00000046951.6 ENSMUST00000046951.7 ENSMUST00000046951.8 ENSMUST00000046951.9 NM_026550 PK1IP_MOUSE Q3UBK7 Q80UT4 Q8C5N6 Q923K2 Q9D3E9 Q9DCE5 uc007qer.1 uc007qer.2 uc007qer.3 uc007qer.4 Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. Interacts with PAK1. Nucleus, nucleolus protein binding nucleus nucleolus cell proliferation negative regulation of signal transduction ribosome biogenesis ribosomal large subunit biogenesis palate development regulation of signal transduction by p53 class mediator uc007qer.1 uc007qer.2 uc007qer.3 uc007qer.4 
ENSMUST00000046955.7 Dnaaf10 ENSMUST00000046955.7 dynein axonemal assembly factor 10 (from RefSeq NM_178909.4) DAA10_MOUSE Dnaaf10 ENSMUST00000046955.1 ENSMUST00000046955.2 ENSMUST00000046955.3 ENSMUST00000046955.4 ENSMUST00000046955.5 ENSMUST00000046955.6 NM_178909 Q8BGF3 Wdr92 uc007icd.1 uc007icd.2 uc007icd.3 Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm. Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92 (By similarity). Interacts with PIH1D1; the interaction associates DNAAF10 with the R2TP complex (By similarity). Interacts with several dynein axonemal assembly factors (By similarity). Dynein axonemal particle cellular_component apoptotic process ubiquitin binding uc007icd.1 uc007icd.2 uc007icd.3 
ENSMUST00000046959.9 Slc22a2 ENSMUST00000046959.9 solute carrier family 22 (organic cation transporter), member 2, transcript variant 1 (from RefSeq NM_013667.3) ENSMUST00000046959.1 ENSMUST00000046959.2 ENSMUST00000046959.3 ENSMUST00000046959.4 ENSMUST00000046959.5 ENSMUST00000046959.6 ENSMUST00000046959.7 ENSMUST00000046959.8 NM_013667 O70577 Oct2 Q8BWF6 Q8K4X8 S22A2_MOUSE Slc22a2 uc008akw.1 uc008akw.2 uc008akw.3 Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:23458604). Functions as a Na(+)-independent, bidirectional uniporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (By similarity). However, may also engage electroneutral cation exchange when saturating concentrations of cation substrates are reached (By similarity). Predominantly expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow. Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the central nervous system by regulating interstitial concentrations of neurotransmitters. Also capable of transporting dopaminergic neuromodulators cyclo(his-pro), salsolinol and N-methyl-salsolinol, thereby involved in the maintenance of dopaminergic cell integrity in the central nervous system. Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium. Also transports guanidine and endogenous monoamines such as vitamin B1/thiamine, creatinine and N-1- methylnicotinamide (NMN). Mediates the uptake and efflux of quaternary ammonium compound choline (By similarity). Mediates the bidirectional transport of polyamine agmatine and the uptake of polyamines putrescine and spermidine (PubMed:23458604). Able to transport non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha). Also involved in the uptake of xenobiotic 4-(4- (dimethylamino)styryl)-N-methylpyridinium (ASP). May contribute to regulate the transport of organic compounds in testis across the blood- testis-barrier (By similarity). Reaction=(R)-noradrenaline(out) = (R)-noradrenaline(in); Xref=Rhea:RHEA:73871, ChEBI:CHEBI:72587; Evidence=; Reaction=(R)-adrenaline(out) = (R)-adrenaline(in); Xref=Rhea:RHEA:73875, ChEBI:CHEBI:71406; Evidence=; Reaction=serotonin(out) = serotonin(in); Xref=Rhea:RHEA:73867, ChEBI:CHEBI:350546; Evidence=; Reaction=dopamine(out) = dopamine(in); Xref=Rhea:RHEA:73863, ChEBI:CHEBI:59905; Evidence=; Reaction=histamine(out) = histamine(in); Xref=Rhea:RHEA:73879, ChEBI:CHEBI:58432; Evidence=; Reaction=thiamine(in) = thiamine(out); Xref=Rhea:RHEA:34919, ChEBI:CHEBI:18385; Evidence=; Reaction=creatinine(in) = creatinine(out); Xref=Rhea:RHEA:74539, ChEBI:CHEBI:16737; Evidence=; Reaction=1-methylnicotinamide(out) = 1-methylnicotinamide(in); Xref=Rhea:RHEA:73859, ChEBI:CHEBI:16797; Evidence=; Reaction=guanidine(out) = guanidine(in); Xref=Rhea:RHEA:73883, ChEBI:CHEBI:30087; Evidence=; Reaction=choline(out) = choline(in); Xref=Rhea:RHEA:32751, ChEBI:CHEBI:15354; Evidence=; Reaction=agmatine(out) = agmatine(in); Xref=Rhea:RHEA:72131, ChEBI:CHEBI:58145; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72132; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:72133; Evidence=; Reaction=putrescine(out) = putrescine(in); Xref=Rhea:RHEA:72135, ChEBI:CHEBI:326268; Evidence=; Reaction=spermidine(in) = spermidine(out); Xref=Rhea:RHEA:35039, ChEBI:CHEBI:57834; Evidence=; Reaction=tyramine(in) = tyramine(out); Xref=Rhea:RHEA:74783, ChEBI:CHEBI:327995; Evidence=; Reaction=L-histidyl-L-proline diketopiperazine(in) = L-histidyl-L- proline diketopiperazine(out); Xref=Rhea:RHEA:74787, ChEBI:CHEBI:90039; Evidence=; Reaction=(R)-salsolinol(in) = (R)-salsolinol(out); Xref=Rhea:RHEA:74791, ChEBI:CHEBI:194082; Evidence=; Reaction=N-methyl-(R)-salsolinol(in) = N-methyl-(R)-salsolinol(out); Xref=Rhea:RHEA:74795, ChEBI:CHEBI:194083; Evidence=; Reaction=acetylcholine(in) = acetylcholine(out); Xref=Rhea:RHEA:74663, ChEBI:CHEBI:15355; Evidence=; Reaction=prostaglandin F2alpha(out) = prostaglandin F2alpha(in); Xref=Rhea:RHEA:50988, ChEBI:CHEBI:57404; Evidence=; Reaction=prostaglandin E2(out) = prostaglandin E2(in); Xref=Rhea:RHEA:50984, ChEBI:CHEBI:606564; Evidence=; Tyrosine phosphorylation of the transporter leads to activation of the transport activity (PubMed:26979622). TEA uptake is activated by tyrosine phosphorylation (PubMed:26979622). Inhibited by cGMP, most likely through a cGMP-binding protein that interacts with OCT2 (By similarity). Basolateral cell membrane ; Multi-pass membrane protein Basal cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O70577-1; Sequence=Displayed; Name=2; IsoId=O70577-2; Sequence=VSP_031775, VSP_031776; Expressed in kidney and ureter (PubMed:10051314, PubMed:26979622). To a lower extent, also expressed in brain and embryo (PubMed:10051314). Contains one proline-rich sequence (Pro-Glu-Ser-Pro-Arg) that may be involved in tyrosine-protein kinase YES1 binding and is required for the activation of substrate transport. Tyrosine phosphorylated by tyrosine-protein kinase YES1. Mediates the renal secretion of many clinically used cationic drugs (PubMed:23458604) (By similarity). Transports drugs such as diabetes treatment medicine metformin and neurotoxins 1-methyl-4- phenylpyridinium (MPP(+)), famotidine, ranitidine, amantadine, acriflavine, amiloride, memantine, cimetidine, cisplatin, oxaliplatin, platinum-based drugs cisplatin and oxaliplatin, 3'-azido-3'- deoxythymidine (AZT) and tetraethylammonium (TEA) (PubMed:23458604). Mediates the bidirectional transport of MPP(+). Metformin competitively inhibits OCT1-mediated thiamine uptake, leading to a decrease in hepatic steatosis. Plays a predominant role in the anticancer activity of cisplatin and oxaliplatin and may contribute to antitumor specificity (By similarity). Involved in cisplatin-induced nephrotoxicity (By similarity). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. While most authors have deduced a localization at the basolateral membrane of proximal tubules, other studies demonstrated a localization to the luminal membrane in the distal tubule. steroid binding integral component of plasma membrane ion transport cation transport organic cation transmembrane transporter activity choline transmembrane transporter activity quaternary ammonium group transmembrane transporter activity organic cation transport quaternary ammonium group transport choline transport membrane integral component of membrane basolateral plasma membrane transmembrane transporter activity histamine transport transmembrane transport uc008akw.1 uc008akw.2 uc008akw.3 
ENSMUST00000046963.10 Map2k4 ENSMUST00000046963.10 mitogen-activated protein kinase kinase 4, transcript variant 2 (from RefSeq NM_009157.5) ENSMUST00000046963.1 ENSMUST00000046963.2 ENSMUST00000046963.3 ENSMUST00000046963.4 ENSMUST00000046963.5 ENSMUST00000046963.6 ENSMUST00000046963.7 ENSMUST00000046963.8 ENSMUST00000046963.9 Map2k4 NM_009157 Q543X6 Q543X6_MOUSE uc007jlb.1 uc007jlb.2 uc007jlb.3 uc007jlb.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. nucleotide binding positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity ATP binding nucleus cytosol protein phosphorylation JNK cascade activation of JUN kinase activity JUN kinase kinase activity axon mitogen-activated protein kinase kinase kinase binding dendrite cytoplasm positive regulation of apoptotic process perikaryon positive regulation of neuron apoptotic process positive regulation of DNA replication positive regulation of nitric-oxide synthase biosynthetic process cell growth involved in cardiac muscle cell development cellular response to mechanical stimulus cellular response to sorbitol uc007jlb.1 uc007jlb.2 uc007jlb.3 uc007jlb.4 
ENSMUST00000046974.5 Fbxw17 ENSMUST00000046974.5 F-box and WD-40 domain protein 17, transcript variant 3 (from RefSeq NR_154273.1) ENSMUST00000046974.1 ENSMUST00000046974.2 ENSMUST00000046974.3 ENSMUST00000046974.4 Fbxw17 NR_154273 Q8CFE8 Q8CFE8_MOUSE uc007qkl.1 uc007qkl.2 uc007qkl.3 molecular_function cellular_component uc007qkl.1 uc007qkl.2 uc007qkl.3 
ENSMUST00000046975.12 Pcgf3 ENSMUST00000046975.12 polycomb group ring finger 3, transcript variant 1 (from RefSeq NM_172716.5) ENSMUST00000046975.1 ENSMUST00000046975.10 ENSMUST00000046975.11 ENSMUST00000046975.2 ENSMUST00000046975.3 ENSMUST00000046975.4 ENSMUST00000046975.5 ENSMUST00000046975.6 ENSMUST00000046975.7 ENSMUST00000046975.8 ENSMUST00000046975.9 NM_172716 PCGF3_MOUSE PcgF3 Q8BTQ0 Q8BZT0 Rnf3 Rnf3a uc008yoe.1 uc008yoe.2 uc008yoe.3 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:28596365). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365). Component of a PRC1-like complex that contains PCGF3, RNF2 and RYBP (PubMed:28596365). Interacts with RNF2 (PubMed:28596365). Interacts with CBX6, CBX7 and CBX8 (By similarity). Interacts with BCORL1 (By similarity). Nucleus Nucleus, nucleoplasm Note=Recruited by the non- coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BTQ0-1; Sequence=Displayed; Name=2; IsoId=Q8BTQ0-2; Sequence=VSP_023116, VSP_023117; Combined disruption of both Pcgf3 and Pcgf5 causes embryonic lethality; there are no live progeny. Male embryos are detected at 9.5 and 10.5 dpc, but are smaller than normal. Female embryos are already extensively degraded at 9.5 dpc. Placentas from male embryos have some parietal trophoblast giant cells, but fail to form a labyrinth. Placentas from female embryos lack trophoblasts altogether and fail to form a labyrinth. Defects can be attributed to the observed lack of monoubiquitination of histone H2A 'Lys-119' and lack of Xist-mediated silencing of one copy of the X chromosome. RNA polymerase II regulatory region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated PcG protein complex PRC1 complex histone H2A-K119 monoubiquitination metal ion binding inactivation of X chromosome by genetic imprinting X chromosome uc008yoe.1 uc008yoe.2 uc008yoe.3 
ENSMUST00000046977.12 Adgrl4 ENSMUST00000046977.12 adhesion G protein-coupled receptor L4 (from RefSeq NM_133222.3) AGRL4_MOUSE E9QLT4 ENSMUST00000046977.1 ENSMUST00000046977.10 ENSMUST00000046977.11 ENSMUST00000046977.2 ENSMUST00000046977.3 ENSMUST00000046977.4 ENSMUST00000046977.5 ENSMUST00000046977.6 ENSMUST00000046977.7 ENSMUST00000046977.8 ENSMUST00000046977.9 Eltd1 NM_133222 Q91W44 Q923X1 uc008rsj.1 uc008rsj.2 uc008rsj.3 uc008rsj.4 Endothelial orphan receptor that acts as a key regulator of angiogenesis. Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C- terminal fragment predominantly remain associated and non-covalently linked. Cell membrane ; Multi-pass membrane protein Induced by VEGF and FGF2. The transmembrane domain is not required for cleavage, but it is required for dimer formation. Glycosylated. Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit. No visible phenotype but deficient mice present increased cardiac hypertrophy in response to pressure overload. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. transmembrane signaling receptor activity G-protein coupled receptor activity calcium ion binding plasma membrane integral component of plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway membrane integral component of membrane cytoplasmic vesicle protein dimerization activity uc008rsj.1 uc008rsj.2 uc008rsj.3 uc008rsj.4 
ENSMUST00000046983.10 Smpd1 ENSMUST00000046983.10 sphingomyelin phosphodiesterase 1, acid lysosomal (from RefSeq NM_011421.2) ASM_MOUSE Asm ENSMUST00000046983.1 ENSMUST00000046983.2 ENSMUST00000046983.3 ENSMUST00000046983.4 ENSMUST00000046983.5 ENSMUST00000046983.6 ENSMUST00000046983.7 ENSMUST00000046983.8 ENSMUST00000046983.9 NM_011421 Q04519 Q3UL52 Smpd1 uc009iyg.1 uc009iyg.2 uc009iyg.3 Converts sphingomyelin to ceramide (PubMed:9660788, PubMed:8706124). Exists as two enzymatic forms that arise from alternative trafficking of a single protein precursor, one that is targeted to the endolysosomal compartment, whereas the other is released extracellularly. However, in response to various forms of stress, lysosomal exocytosis may represent a major source of the secretory form (By similarity). In the lysosomes, converts sphingomyelin to ceramide. Plays an important role in the export of cholesterol from the intraendolysosomal membranes. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2- diacylglycerolphosphoglycerol (PubMed:27435900). Modulates stress- induced apoptosis through the production of ceramide (PubMed:8706124). When secreted, modulates cell signaling with its ability to reorganize the plasma membrane by converting sphingomyelin to ceramide. Secreted form is increased in response to stress and inflammatory mediators such as IL1B, IFNG or TNF as well as upon infection with bacteria and viruses. Produces the release of ceramide in the outer leaflet of the plasma membrane playing a central role in host defense. Ceramide reorganizes these rafts into larger signaling platforms that are required to internalize P. aeruginosa, induce apoptosis and regulate the cytokine response in infected cells. In wounded cells, the lysosomal form is released extracellularly in the presence of Ca(2+) and promotes endocytosis and plasma membrane repair. [Sphingomyelin phosphodiesterase, processed form]: This form is generated following cleavage by CASP7 in the extracellular milieu in response to bacterial infection (PubMed:35705808). It shows increased ability to convert sphingomyelin to ceramide and promotes plasma membrane repair. Plasma membrane repair by ceramide counteracts the action of gasdermin-D (GSDMD) perforin (PRF1) pores that are formed in response to bacterial infection (PubMed:35705808). (Microbial infection) Secretion is activated by bacteria such as P. aeruginos, this activation results in the release of ceramide in the outer leaflet of the plasma membrane which facilitates the infection. Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:295975; EC=3.1.4.12; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19254; Evidence=; Reaction=H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-octadecanoylsphing-4-enine + phosphocholine; Xref=Rhea:RHEA:54284, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72961, ChEBI:CHEBI:83358, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54285; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl- sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:10604, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57643, ChEBI:CHEBI:295975; EC=3.1.4.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10605; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2- dihexadecanoyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:45304, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:82929, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45305; Evidence=; [Sphingomyelin phosphodiesterase, processed form]: Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:295975; EC=3.1.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19254; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit (PubMed:27435900).; Hydrolysis of liposomal sphingomyelin is stimulated by incorporation of diacylglycerol (DAG), ceramide and free fatty acids into the liposomal membranes. Phosphatidylcholine hydrolysis is inhibited by incorporation of cholesterol, ceramide, DAG, monoacylglycerol and fatty acids. Monomer (PubMed:27435900). Interacts with SORT1; the interaction is required for SMPD1 targeting to lysosomes (By similarity). Lysosome Lipid droplet Secreted Note=The secreted form is induced in a time- and dose-dependent by IL1B and TNF as well as stress and viral infection. This increase of the secreted form seems to be due to exocytosis of the lysosomal form and is Ca(2+)-dependent. Secretion is dependent of phosphorylation at Ser-506. Secretion is induced by inflammatory mediators such as IL1B, IFNG or TNF as well as infection with bacteria and viruses. [Sphingomyelin phosphodiesterase, processed form]: Secreted, extracellular space Note=This form is generated following cleavage by CASP7. Proteolytically processed. Mature lysosomal form arises from C- terminal proteolytic processing of pro-sphingomyelin phosphodiesterase. Both lysosomal and secreted forms are glycosylated but they show a differential pattern of glycosylation. Phosphorylated at Ser-506 by PRKCD upon stress stimuli. Phosphorylation is required for secretion. [Sphingomyelin phosphodiesterase, processed form]: This form is generated following cleavage by CASP7 in the extracellular milieu (PubMed:35705808). It shows increased activity (PubMed:35705808). Mutants infected with Pseudomonas aeruginosa die within 7 days whereas all wild-type mice survive the infection (PubMed:12563314). Mutants are defective in radiation-induced apoptosis (PubMed:8706124). There are two types of sphingomyelinases: ASM (acid), and NSM (neutral). Belongs to the acid sphingomyelinase family. sphingomyelin phosphodiesterase activity extracellular region extracellular space lysosome endosome plasma membrane ceramide metabolic process sphingomyelin catabolic process phosphoric diester hydrolase activity metabolic process cholesterol metabolic process zinc ion binding hydrolase activity hydrolase activity, acting on glycosyl bonds termination of signal transduction positive regulation of protein dephosphorylation response to cocaine response to drug lamellar body positive regulation of apoptotic process negative regulation of MAP kinase activity ceramide biosynthetic process metal ion binding acid sphingomyelin phosphodiesterase activity uc009iyg.1 uc009iyg.2 uc009iyg.3 
ENSMUST00000046999.12 Abhd11 ENSMUST00000046999.12 abhydrolase domain containing 11, transcript variant 1 (from RefSeq NM_145215.2) ABHDB_MOUSE Abhd11 ENSMUST00000046999.1 ENSMUST00000046999.10 ENSMUST00000046999.11 ENSMUST00000046999.2 ENSMUST00000046999.3 ENSMUST00000046999.4 ENSMUST00000046999.5 ENSMUST00000046999.6 ENSMUST00000046999.7 ENSMUST00000046999.8 ENSMUST00000046999.9 NM_145215 Q8K4F5 Wbscr21 uc008zxg.1 uc008zxg.2 uc008zxg.3 Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol (By similarity). 1,2-diacyl- sn-glycerols are the preferred substrate over 1,3-diacyl-sn-glycerols. The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols (By similarity). Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts (By similarity). In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs) (PubMed:32733886). Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate; Xref=Rhea:RHEA:38507, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:52392, ChEBI:CHEBI:75728; Evidence=; Reaction=a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:33275, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17389, ChEBI:CHEBI:17815, ChEBI:CHEBI:28868; EC=3.1.1.116; Evidence=; Reaction=a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+); Xref=Rhea:RHEA:38503, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:64683, ChEBI:CHEBI:77272; Evidence=; Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z- octadecenoyl)-glycerol + H(+) + octadecanoate; Xref=Rhea:RHEA:77103, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:73990, ChEBI:CHEBI:75468; Evidence=; Reaction=1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+) + octadecanoate; Xref=Rhea:RHEA:77107, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:77129, ChEBI:CHEBI:186738; Evidence=; Reaction=1,2-didecanoylglycerol + H2O = decanoate + decanoylglycerol + H(+); Xref=Rhea:RHEA:48596, ChEBI:CHEBI:11152, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:90605; Evidence=; Interacts with OGDH and DLST; this interaction maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex. Mitochondrion Mitochondrion matrix Expressed in white adipose tissues. Up-regulated by rosiglitazone and down-regulated by high fat feeding. Phosphorylated. Homozygoud knockout mice lacking Abhd11 are viable and only a slight but significant reduction in body weight has been noticed in males exclusively (PubMed:32579589). In addition, less abdominal fat deposit is observed (PubMed:32579589). Mice show some eye defects, including iris synechiae, melanophagy in the iris or the ciliary body, cataract (with reduced lens size when advanced) and retinal atrophy (PubMed:32579589). That such ophthalmologic defects lead to blindness in 9-week old male KO mice (PubMed:32579589). Belongs to the AB hydrolase superfamily. catalytic activity mitochondrion hydrolase activity uc008zxg.1 uc008zxg.2 uc008zxg.3 
ENSMUST00000047005.11 Spata16 ENSMUST00000047005.11 spermatogenesis associated 16, transcript variant 2 (from RefSeq NM_029150.4) ENSMUST00000047005.1 ENSMUST00000047005.10 ENSMUST00000047005.2 ENSMUST00000047005.3 ENSMUST00000047005.4 ENSMUST00000047005.5 ENSMUST00000047005.6 ENSMUST00000047005.7 ENSMUST00000047005.8 ENSMUST00000047005.9 NM_029150 Q8C636 Q9D5W9 SPT16_MOUSE uc008otg.1 uc008otg.2 uc008otg.3 Essential for spermiogenesis and male fertility (PubMed:29065458). Involved in the formation of acrosome during spermatogenesis (PubMed:16372119). Golgi apparatus toplasmic vesicle, secretory vesicle, acrosome Note=Shift from Golgi to sperm acrosome. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C636-1; Sequence=Displayed; Name=2; IsoId=Q8C636-2; Sequence=VSP_030726; Testis-specific. Expressed in spermatocytes and round and elongated spermatids in the seminiferous tubules. Male mice are infertile with spermiogenic arrest and impaired differentiation of round spermatids into the mature spermatozoa. Belongs to the SPATA16 family. acrosomal vesicle molecular_function Golgi apparatus multicellular organism development spermatogenesis biological_process cell differentiation cytoplasmic vesicle uc008otg.1 uc008otg.2 uc008otg.3 
ENSMUST00000047013.4 Cmtm8 ENSMUST00000047013.4 CKLF-like MARVEL transmembrane domain containing 8 (from RefSeq NM_027294.2) CKLF8_MOUSE Cklfsf8 ENSMUST00000047013.1 ENSMUST00000047013.2 ENSMUST00000047013.3 NM_027294 Q9CZR4 uc009ryg.1 uc009ryg.2 Membrane; Multi-pass membrane protein. Belongs to the chemokine-like factor family. cytokine activity extracellular space nucleoplasm chemotaxis signal transduction membrane integral component of membrane structural constituent of myelin sheath myelination uc009ryg.1 uc009ryg.2 
ENSMUST00000047025.15 Otoa ENSMUST00000047025.15 otoancorin (from RefSeq NM_139310.2) ENSMUST00000047025.1 ENSMUST00000047025.10 ENSMUST00000047025.11 ENSMUST00000047025.12 ENSMUST00000047025.13 ENSMUST00000047025.14 ENSMUST00000047025.2 ENSMUST00000047025.3 ENSMUST00000047025.4 ENSMUST00000047025.5 ENSMUST00000047025.6 ENSMUST00000047025.7 ENSMUST00000047025.8 ENSMUST00000047025.9 NM_139310 OTOAN_MOUSE Q8K561 uc009jnn.1 uc009jnn.2 uc009jnn.3 May act as an adhesion molecule. Apical cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side Secreted, extracellular space, extracellular matrix Note=At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes. Expressed in the inner ear and vestibule. Expressed in cochlea on the upper surface of the spiral limbus at 16.5 dpc onwards. Belongs to the stereocilin family. molecular_function extracellular region plasma membrane cell-matrix adhesion sensory perception of sound cell surface membrane apical plasma membrane transmission of nerve impulse anchored component of membrane uc009jnn.1 uc009jnn.2 uc009jnn.3 
ENSMUST00000047028.9 Lgalsl ENSMUST00000047028.9 galectin like (from RefSeq NM_173752.4) ENSMUST00000047028.1 ENSMUST00000047028.2 ENSMUST00000047028.3 ENSMUST00000047028.4 ENSMUST00000047028.5 ENSMUST00000047028.6 ENSMUST00000047028.7 ENSMUST00000047028.8 Grpa LEGL_MOUSE Lgalsla NM_173752 Q8C4P8 Q8VED9 uc007idj.1 uc007idj.2 uc007idj.3 uc007idj.4 Does not bind lactose, and may not bind carbohydrates. Monomer. Most of the residues in the galectin domain that have been shown to be critical for carbohydrate-binding in other galectins are not conserved. molecular_function cytoplasm biological_process carbohydrate binding uc007idj.1 uc007idj.2 uc007idj.3 uc007idj.4 
ENSMUST00000047034.9 Ttbk1 ENSMUST00000047034.9 tau tubulin kinase 1 (from RefSeq NM_001162864.2) ENSMUST00000047034.1 ENSMUST00000047034.2 ENSMUST00000047034.3 ENSMUST00000047034.4 ENSMUST00000047034.5 ENSMUST00000047034.6 ENSMUST00000047034.7 ENSMUST00000047034.8 NM_001162864 Q6PCN3 TTBK1_MOUSE uc008csx.1 uc008csx.2 uc008csx.3 Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Divalent metal cations. Mg(2+) or, to a lesser extent, Mn(2+), but not Ca(2+) or Zn(2+). ; Cytoplasm Expressed in the brain. Strong expression in the cortical layers, the CA1 layers of the hippocampus and the granular layer of the cerebellum. Also expressed in the large cortical pyramidal cells in the temporal cortex, the CA1 pyramidal neurons and the cerebellum granular neurons. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity ATP binding nucleus nucleoplasm cytoplasm cytosol microtubule associated complex protein phosphorylation learning or memory positive regulation of gene expression negative regulation of gene expression kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation negative regulation of protein binding positive regulation of protein polymerization neuronal cell body tau protein binding perinuclear region of cytoplasm tau-protein kinase activity positive regulation of microglial cell activation positive regulation of cyclin-dependent protein kinase activity positive regulation of cysteine-type endopeptidase activity uc008csx.1 uc008csx.2 uc008csx.3 
ENSMUST00000047036.10 Polr1g ENSMUST00000047036.10 RNA polymerase I subunit G (from RefSeq NM_145822.2) Ase1 Cd3eap ENSMUST00000047036.1 ENSMUST00000047036.2 ENSMUST00000047036.3 ENSMUST00000047036.4 ENSMUST00000047036.5 ENSMUST00000047036.6 ENSMUST00000047036.7 ENSMUST00000047036.8 ENSMUST00000047036.9 NM_145822 Paf49 Polr1g Q76KJ5 Q8K0Y9 RPA34_MOUSE uc009fln.1 uc009fln.2 uc009fln.3 uc009fln.4 uc009fln.5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Involved in UBTF-activated transcription, presumably at a step following PIC formation. Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits. Interacts with TAF1A thereby associates with the SL1 complex. Interacts with UBTF (By similarity). Interacts with POLR1E/PRAF1 through its N-terminal region. Nucleus, nucleolus Note=Accumulates in the nucleolus of exponentially growing cells. It is in an antisense orientation to and overlaps the gene of the DNA repair enzyme ERCC1. This gene overlap is conserved in human, suggesting an important biological function. Belongs to the eukaryotic RPA34 RNA polymerase subunit family. fibrillar center protein binding nucleus nucleolus DNA-directed RNA polymerase I complex mitochondrion cytosol transcription from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter rRNA transcription transcription of nuclear large rRNA transcript from RNA polymerase I promoter RNA polymerase I activity uc009fln.1 uc009fln.2 uc009fln.3 uc009fln.4 uc009fln.5 
ENSMUST00000047037.15 Thoc2 ENSMUST00000047037.15 THO complex 2 (from RefSeq NM_001033422.1) B1AZI6 ENSMUST00000047037.1 ENSMUST00000047037.10 ENSMUST00000047037.11 ENSMUST00000047037.12 ENSMUST00000047037.13 ENSMUST00000047037.14 ENSMUST00000047037.2 ENSMUST00000047037.3 ENSMUST00000047037.4 ENSMUST00000047037.5 ENSMUST00000047037.6 ENSMUST00000047037.7 ENSMUST00000047037.8 ENSMUST00000047037.9 NM_001033422 THOC2_MOUSE uc009tao.1 uc009tao.2 uc009tao.3 Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Plays a role for proper neuronal development. Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A (By similarity). Nucleus Nucleus speckle Expressed in the hippocampus and the cortical neurons. Belongs to the THOC2 family. transcription export complex THO complex THO complex part of transcription export complex cell morphogenesis blastocyst development RNA binding mRNA binding protein binding nucleus mRNA processing mRNA export from nucleus RNA splicing regulation of gene expression regulation of mRNA export from nucleus negative regulation of neuron projection development nuclear speck poly(A)+ mRNA export from nucleus stem cell division viral mRNA export from host cell nucleus neuron development generation of neurons mRNA transport nuclear chromosome, telomeric region uc009tao.1 uc009tao.2 uc009tao.3 
ENSMUST00000047040.4 Cavin3 ENSMUST00000047040.4 caveolae associated 3 (from RefSeq NM_028444.1) CAVN3_MOUSE ENSMUST00000047040.1 ENSMUST00000047040.2 ENSMUST00000047040.3 NM_028444 Prkcdbp Q8C064 Q91VJ2 Q9CRW1 Srbc uc009iye.1 uc009iye.2 uc009iye.3 Regulates the traffic and/or budding of caveolae (By similarity). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells (PubMed:28285351, PubMed:23652019). Regulates the equilibrium between cell surface- associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface (PubMed:25588833). Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (PubMed:23079727). Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4 (PubMed:19546242). Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding (PubMed:9054438). Interacts with PER2 (PubMed:23079727). Interacts with CAVIN1 (PubMed:19546242, PubMed:25588833). Interacts (via leucine-zipper domain) with CAV1 in a cholesterol-sensitive manner (PubMed:25588833). Interacts with EPS15L1 (By similarity). Q91VJ2; O54943: Per2; NbExp=4; IntAct=EBI-8094261, EBI-1266779; Cytoplasm Cytoplasm, cytosol Membrane, caveola Note=Localizes in the caveolae in a caveolin-dependent manner. Lung, heart, skeletal muscle, liver, brain, vascular and urinary bladder smooth muscle (at protein level). Strongly expressed in uterus, ovary, mammary and epithelial cells. Also expressed in spleen, intestine, kidney and testis. Up-regulated in serum-starvated cells or during cell growth arrest. The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1. In vitro, phosphorylated by PRKCD. Mice show reduced density of membrane caveolae in the arterial smooth muscle and the urinary bladder but show no loss of endothelial caveolae in lung and heart. Belongs to the CAVIN family. protein kinase C binding protein binding cytoplasm cytosol caveola membrane cortical actin cytoskeleton organization circadian regulation of gene expression macromolecular complex rhythmic process negative regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade negative regulation of fermentation uc009iye.1 uc009iye.2 uc009iye.3 
ENSMUST00000047045.10 Acsm4 ENSMUST00000047045.10 acyl-CoA synthetase medium-chain family member 4 (from RefSeq NM_178414.3) ACSM4_MOUSE ENSMUST00000047045.1 ENSMUST00000047045.2 ENSMUST00000047045.3 ENSMUST00000047045.4 ENSMUST00000047045.5 ENSMUST00000047045.6 ENSMUST00000047045.7 ENSMUST00000047045.8 ENSMUST00000047045.9 NM_178414 Omacs Q80W40 uc009jln.1 uc009jln.2 uc009jln.3 uc009jln.4 Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for C6-12 fatty acids (By similarity). Reaction=a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:48340, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:59558, ChEBI:CHEBI:90546, ChEBI:CHEBI:456215; EC=6.2.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48341; Evidence=; Reaction=ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA; Xref=Rhea:RHEA:43740, ChEBI:CHEBI:17120, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:62620, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43741; Evidence=; Reaction=ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA; Xref=Rhea:RHEA:33631, ChEBI:CHEBI:25646, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33632; Evidence=; Reaction=ATP + CoA + decanoate = AMP + decanoyl-CoA + diphosphate; Xref=Rhea:RHEA:33627, ChEBI:CHEBI:27689, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33628; Evidence=; Reaction=ATP + CoA + dodecanoate = AMP + diphosphate + dodecanoyl-CoA; Xref=Rhea:RHEA:33623, ChEBI:CHEBI:18262, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33624; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Mitochondrion Belongs to the ATP-dependent AMP-binding enzyme family. nucleotide binding catalytic activity acyl-CoA ligase activity fatty-acyl-CoA synthase activity ATP binding mitochondrion mitochondrial matrix lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process acyl-CoA metabolic process fatty acid ligase activity ligase activity metal ion binding butyrate-CoA ligase activity decanoate--CoA ligase activity uc009jln.1 uc009jln.2 uc009jln.3 uc009jln.4 
ENSMUST00000047055.4 Lce1c ENSMUST00000047055.4 late cornified envelope 1C (from RefSeq NM_028622.2) ENSMUST00000047055.1 ENSMUST00000047055.2 ENSMUST00000047055.3 Lce1c NM_028622 Q9D1C5 Q9D1C5_MOUSE uc008qel.1 uc008qel.2 epidermis development uc008qel.1 uc008qel.2 
ENSMUST00000047057.9 Dpcd ENSMUST00000047057.9 deleted in primary ciliary dyskinesia, transcript variant 1 (from RefSeq NM_172639.3) DPCD_MOUSE ENSMUST00000047057.1 ENSMUST00000047057.2 ENSMUST00000047057.3 ENSMUST00000047057.4 ENSMUST00000047057.5 ENSMUST00000047057.6 ENSMUST00000047057.7 ENSMUST00000047057.8 NM_172639 Q8BPA8 Q8K1L8 uc008hrd.1 uc008hrd.2 uc008hrd.3 uc008hrd.4 May play a role in the formation or function of ciliated cells. Q8BPA8; Q9Y230: RUVBL2; Xeno; NbExp=2; IntAct=EBI-26898155, EBI-352939; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BPA8-1; Sequence=Displayed; Name=2; IsoId=Q8BPA8-2; Sequence=VSP_032081, VSP_032082; Belongs to the DPCD family. epithelial cilium movement molecular_function extracellular region spermatogenesis determination of left/right symmetry ventricular system development lateral ventricle development third ventricle development flagellated sperm motility left/right pattern formation uc008hrd.1 uc008hrd.2 uc008hrd.3 uc008hrd.4 
ENSMUST00000047075.14 Setd1a ENSMUST00000047075.14 Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (PubMed:24550110, PubMed:29490266, PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (By similarity). (from UniProt E9PYH6) BC066039 E9PYH6 ENSMUST00000047075.1 ENSMUST00000047075.10 ENSMUST00000047075.11 ENSMUST00000047075.12 ENSMUST00000047075.13 ENSMUST00000047075.2 ENSMUST00000047075.3 ENSMUST00000047075.4 ENSMUST00000047075.5 ENSMUST00000047075.6 ENSMUST00000047075.7 ENSMUST00000047075.8 ENSMUST00000047075.9 SET1A_MOUSE uc291vxm.1 uc291vxm.2 Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (PubMed:24550110, PubMed:29490266, PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (By similarity). Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265; Evidence=; Reaction=N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60268, Rhea:RHEA-COMP:15540, Rhea:RHEA- COMP:15543, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60269; Evidence=; Reaction=N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L- methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60272, Rhea:RHEA- COMP:15537, Rhea:RHEA-COMP:15540, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961, ChEBI:CHEBI:61976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60273; Evidence=; Component of the SET1A complex composed of the catalytic subunit SETD1A, WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 homotrimer (By similarity). Forms a core complex with the evolutionary conserved subcomplex WRAD composed of WDR5, RBBP5, ASH2L/ASH2 and DPY30 subunits; WRAD differentially stimulates the methyltransferase activity (By similarity). Interacts with BOD1L1 (via COMPASS-Shg1 domain) at replication forks (By similarity). Interacts with HCFC1. Interacts with ASH2/ASH2L, CXXC1/CFP1 and RBBP5. Interacts (via the RRM domain) with WDR82. Interacts (via the RRM domain) with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) only in the presence of WDR82. Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad. Interacts with ZNF335. Interacts with SUPT6H (By similarity). Interacts with NAP1L1 (PubMed:29490266). Interacts (via WIN motif) with WDR5 (By similarity). Nucleus Nucleus speckle Chromosome Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes. High expression is detected in the oocyte that declines to a stable level from the 8-cell stage until 8.5 dpc. Mutant embryos fail to gastrulate and die before or at 7.5 dpc. Belongs to the class V-like SAM-binding methyltransferase superfamily. nuclear chromatin nucleic acid binding RNA binding protein binding nucleus chromosome nuclear euchromatin chromatin organization beta-catenin binding transcription factor binding methyltransferase activity positive regulation of gene expression nuclear speck transferase activity histone-lysine N-methyltransferase activity stem cell population maintenance methylation histone methyltransferase complex histone methyltransferase activity (H3-K4 specific) regulation of erythrocyte differentiation chromatin-mediated maintenance of transcription Set1C/COMPASS complex histone H3-K4 methylation regulation of hematopoietic stem cell differentiation regulation of chromatin organization euchromatin binding positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation uc291vxm.1 uc291vxm.2 
ENSMUST00000047085.16 Tbc1d17 ENSMUST00000047085.16 TBC1 domain family, member 17, transcript variant 6 (from RefSeq NM_001420372.1) ENSMUST00000047085.1 ENSMUST00000047085.10 ENSMUST00000047085.11 ENSMUST00000047085.12 ENSMUST00000047085.13 ENSMUST00000047085.14 ENSMUST00000047085.15 ENSMUST00000047085.2 ENSMUST00000047085.3 ENSMUST00000047085.4 ENSMUST00000047085.5 ENSMUST00000047085.6 ENSMUST00000047085.7 ENSMUST00000047085.8 ENSMUST00000047085.9 NM_001420372 Q3TCA5 Q8BYH7 TBC17_MOUSE uc009grc.1 uc009grc.2 uc009grc.3 Probable GTPase-activating protein that inhibits RAB8A/B function. Reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC) and inhibits Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TfR). Involved in regulation of autophagy. Interacts with OPTN; this interaction mediates TBC1D17 transient association with Rab8. Cytoplasmic vesicle, autophagosome Cytoplasm Recycling endosome Note=In the presence of optineurin/OPTN, may be recruited to recycling endosomes. The arginine and glutamine fingers are critical for the GTPase- activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site. GTPase activator activity autophagosome cytosol intracellular protein transport autophagy protein transport Rab GTPase binding cytoplasmic vesicle retrograde transport, endosome to Golgi activation of GTPase activity uc009grc.1 uc009grc.2 uc009grc.3 
ENSMUST00000047086.10 Wdr43 ENSMUST00000047086.10 WD repeat domain 43 (from RefSeq NM_175639.1) ENSMUST00000047086.1 ENSMUST00000047086.2 ENSMUST00000047086.3 ENSMUST00000047086.4 ENSMUST00000047086.5 ENSMUST00000047086.6 ENSMUST00000047086.7 ENSMUST00000047086.8 ENSMUST00000047086.9 Kiaa0007 NM_175639 Q3U895 Q6ZQL4 WDR43_MOUSE uc008dms.1 uc008dms.2 uc008dms.3 uc008dms.4 Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (By similarity). Essential for stem cell pluripotency and embryonic development (PubMed:31128943). In the nucleoplasm, recruited by promoter- associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high- level expression of its targets genes (PubMed:31128943). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75 (By similarity). Binds to RNA; binding is required for its chromatin association (PubMed:31128943). Interacts with CDK9, DDX21 and SUPT6H (PubMed:31128943). Interacts with RNA polymerase II (PubMed:31128943). Interacts directly with UTP4 and UTP15 (By similarity). Nucleus, nucleolus Nucleus, nucleolus fibrillar center Nucleus, nucleoplasm Detected at low levels at least in heart, liver, lung, spleen, thymus and hippocampus. Expressed during embryonic development, expression decreases at morula stage. N-terminal domain is required for nucleoplasm location and C- terminal domain for nucleolus location. Belongs to the UTP5 family. chromatin RNA polymerase II core binding fibrillar center obsolete transcription elongation regulator activity protein binding nucleus nucleoplasm nucleolus rRNA processing regulation of transcription elongation from RNA polymerase II promoter ribosome biogenesis positive regulation of transcription from RNA polymerase I promoter regulation of stem cell population maintenance positive regulation of rRNA processing uc008dms.1 uc008dms.2 uc008dms.3 uc008dms.4 
ENSMUST00000047091.14 Btbd10 ENSMUST00000047091.14 BTB domain containing 10 (from RefSeq NM_133700.3) BTBDA_MOUSE ENSMUST00000047091.1 ENSMUST00000047091.10 ENSMUST00000047091.11 ENSMUST00000047091.12 ENSMUST00000047091.13 ENSMUST00000047091.2 ENSMUST00000047091.3 ENSMUST00000047091.4 ENSMUST00000047091.5 ENSMUST00000047091.6 ENSMUST00000047091.7 ENSMUST00000047091.8 ENSMUST00000047091.9 Gmrp1 NM_133700 Q80X66 uc009jhl.1 uc009jhl.2 uc009jhl.3 Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. Interacts (via C-terminal 330-amino-acid region) with AKT1; AKT2 and AKT3 (PubMed:18160256). Interacts with PPP2CA and PPP1CA (PubMed:18160256). Nucleus Cytoplasm Note=Colocalizes with KCTD20 in filamentous structures. Ubiquitously expressed (at protein level). fibrillar center protein binding nucleus cytoplasm positive regulation of phosphorylation type B pancreatic cell proliferation negative regulation of neuron death uc009jhl.1 uc009jhl.2 uc009jhl.3 
ENSMUST00000047098.7 Mslnl ENSMUST00000047098.7 mesothelin-like (from RefSeq NM_177822.3) ENSMUST00000047098.1 ENSMUST00000047098.2 ENSMUST00000047098.3 ENSMUST00000047098.4 ENSMUST00000047098.5 ENSMUST00000047098.6 MSLNL_MOUSE Mpfl NM_177822 Q8C160 uc008bbn.1 uc008bbn.2 uc008bbn.3 May play a role in cellular adhesion. Membrane ; Single-pass type I membrane protein Belongs to the mesothelin family. molecular_function cell adhesion cell-matrix adhesion cell surface membrane integral component of membrane uc008bbn.1 uc008bbn.2 uc008bbn.3 
ENSMUST00000047119.5 Crygn ENSMUST00000047119.5 crystallin, gamma N (from RefSeq NM_153076.3) CRGN_MOUSE Crygn ENSMUST00000047119.1 ENSMUST00000047119.2 ENSMUST00000047119.3 ENSMUST00000047119.4 NM_153076 Q0IJ73 Q0VAU5 Q8VHL5 uc008wsi.1 uc008wsi.2 uc008wsi.3 uc008wsi.4 Crystallins are the dominant structural components of the vertebrate eye lens (Probable). Also plays an important role for integrity and function of auditory nuclei (PubMed:27517863). Monomer. Primordially eye-specific. Present in lens nucleus. In the retina, expression in observed in the outer plexiform layer (containing photoreceptors axons and synapses) and photoreceptor outer segments (at protein level) (PubMed:15853812). Also detected in the auditory hindbrain where it is highly expressed in the medial nucleus of the trapezoid body, but also present in other nuclei of the superior olivary complex (PubMed:27517863). Has a two-domain beta-structure, folded into four very similar Greek key motifs. Belongs to the beta/gamma-crystallin family. lens development in camera-type eye structural constituent of eye lens cellular_component visual perception uc008wsi.1 uc008wsi.2 uc008wsi.3 uc008wsi.4 
ENSMUST00000047131.16 Ipo4 ENSMUST00000047131.16 importin 4, transcript variant 3 (from RefSeq NR_153401.1) ENSMUST00000047131.1 ENSMUST00000047131.10 ENSMUST00000047131.11 ENSMUST00000047131.12 ENSMUST00000047131.13 ENSMUST00000047131.14 ENSMUST00000047131.15 ENSMUST00000047131.2 ENSMUST00000047131.3 ENSMUST00000047131.4 ENSMUST00000047131.5 ENSMUST00000047131.6 ENSMUST00000047131.7 ENSMUST00000047131.8 ENSMUST00000047131.9 IPO4_MOUSE Imp4a NR_153401 Q3TBW0 Q8VI75 Q99J52 Ranbp4 uc007tzp.1 uc007tzp.2 uc007tzp.3 Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B). Mediates the ligand-independent nuclear import of vitamin D receptor (VDR). Found in a cytosolic complex with ASF1 (ASF1A or ASF1B) and histones H3 and H4. Cytoplasm Nucleus Belongs to the importin beta family. Sequence=AAH03469.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC26988.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nuclear chromatin protein binding nucleus cytoplasm DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly protein import into nucleus intracellular protein transport nuclear localization sequence binding Ran GTPase binding protein transport macromolecular complex ribosome biogenesis nuclear import signal receptor activity uc007tzp.1 uc007tzp.2 uc007tzp.3 
ENSMUST00000047134.8 Sdr9c7 ENSMUST00000047134.8 4short chain dehydrogenase/reductase family 9C, member 7 (from RefSeq NM_027301.3) DR9C7_MOUSE ENSMUST00000047134.1 ENSMUST00000047134.2 ENSMUST00000047134.3 ENSMUST00000047134.4 ENSMUST00000047134.5 ENSMUST00000047134.6 ENSMUST00000047134.7 NM_027301 Q8K3P0 Rdhs Sdro uc007hkw.1 uc007hkw.2 uc007hkw.3 uc007hkw.4 Displays weak conversion of all-trans-retinal to all-trans- retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity (By similarity). Cytoplasm Highly expressed in liver. Belongs to the short-chain dehydrogenases/reductases (SDR) family. retinol dehydrogenase activity nucleolus cytoplasm cytosol oxidoreductase activity oxidation-reduction process uc007hkw.1 uc007hkw.2 uc007hkw.3 uc007hkw.4 
ENSMUST00000047144.13 5031439G07Rik ENSMUST00000047144.13 RIKEN cDNA 5031439G07 gene, transcript variant 1 (from RefSeq NM_001368660.1) ENSMUST00000047144.1 ENSMUST00000047144.10 ENSMUST00000047144.11 ENSMUST00000047144.12 ENSMUST00000047144.2 ENSMUST00000047144.3 ENSMUST00000047144.4 ENSMUST00000047144.5 ENSMUST00000047144.6 ENSMUST00000047144.7 ENSMUST00000047144.8 ENSMUST00000047144.9 K0930_MOUSE NM_001368660 Q3TCU3 Q3UE31 uc289ajy.1 uc289ajy.2 Sequence=BAE29080.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE41862.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process uc289ajy.1 uc289ajy.2 
ENSMUST00000047145.14 Trim41 ENSMUST00000047145.14 tripartite motif-containing 41 (from RefSeq NM_145377.2) ENSMUST00000047145.1 ENSMUST00000047145.10 ENSMUST00000047145.11 ENSMUST00000047145.12 ENSMUST00000047145.13 ENSMUST00000047145.2 ENSMUST00000047145.3 ENSMUST00000047145.4 ENSMUST00000047145.5 ENSMUST00000047145.6 ENSMUST00000047145.7 ENSMUST00000047145.8 ENSMUST00000047145.9 NM_145377 Q5NCC3 TRI41_MOUSE Trim41 uc007ipc.1 uc007ipc.2 uc007ipc.3 E3 ligase that plays essential roles in innate antiviral response (PubMed:33640899). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (By similarity). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (By similarity). Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (PubMed:33640899). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:30485814). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with PRKCA. Interacts with NOD2 (By similarity). Interacts with TRIM17; this interaction prevents TRIM41 activity on ZSCAN2 (PubMed:30485814). Cytoplasm Nucleus Auto-ubiquitinated. Deletion mutant impairs the production of inflammatory cytokines and type I interferons in macrophages after infection with both DNA and RNA viruses. Belongs to the TRIM/RBCC family. protein binding nucleus nucleolus cytoplasm zinc ion binding protein ubiquitination nuclear body transferase activity identical protein binding metal ion binding cellular response to lipopolysaccharide cellular response to muramyl dipeptide uc007ipc.1 uc007ipc.2 uc007ipc.3 
ENSMUST00000047153.4 Lce1f ENSMUST00000047153.4 late cornified envelope 1F (from RefSeq NM_026394.3) B9EJP6 B9EJP6_MOUSE ENSMUST00000047153.1 ENSMUST00000047153.2 ENSMUST00000047153.3 Lce1f NM_026394 uc008qeo.1 uc008qeo.2 uc008qeo.3 uc008qeo.4 epidermis development uc008qeo.1 uc008qeo.2 uc008qeo.3 uc008qeo.4 
ENSMUST00000047168.13 Pde9a ENSMUST00000047168.13 phosphodiesterase 9A, transcript variant 1 (from RefSeq NM_008804.5) ENSMUST00000047168.1 ENSMUST00000047168.10 ENSMUST00000047168.11 ENSMUST00000047168.12 ENSMUST00000047168.2 ENSMUST00000047168.3 ENSMUST00000047168.4 ENSMUST00000047168.5 ENSMUST00000047168.6 ENSMUST00000047168.7 ENSMUST00000047168.8 ENSMUST00000047168.9 NM_008804 O70628 PDE9A_MOUSE Pde8b uc008bva.1 uc008bva.2 uc008bva.3 uc008bva.4 uc008bva.5 Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:9624145). Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide- dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide- dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic- peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (PubMed:22328573, PubMed:24746365). Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, ChEBI:CHEBI:58115; EC=3.1.4.35; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 Zn(2+) ion per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Tightly binds zinc. ; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ions per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Binds magnesium less tightly than zinc. ; Inhibited by SCH 51866 and moderately, by zaprinast. Specifically inhibited by PF-04447943 (6-[(3S,4S)-4-methyl- 1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)- 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) (PubMed:22328573). Kinetic parameters: KM=0.07 mM for cGMP ; Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1. Homodimer. Cell projection, ruffle membrane Cytoplasm, perinuclear region Golgi apparatus Endoplasmic reticulum Cell membrane, sarcolemma Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced.; Name=1; IsoId=O70628-1; Sequence=Displayed; Highly expressed in kidney. Lower levels in liver, lung and brain (PubMed:9624145). Widely expressed in brain, with highest expression in cerebellar Purkinje cells (PubMed:14501210). Present in heart (at protein level) (PubMed:25799991). Mice hearts develop less dilation and dysfunction when exposed to sustained pressure overload. Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily. 3',5'-cyclic-nucleotide phosphodiesterase activity cytoplasm endoplasmic reticulum Golgi apparatus plasma membrane signal transduction phosphoric diester hydrolase activity positive regulation of cardiac muscle hypertrophy membrane hydrolase activity cGMP-mediated signaling ruffle membrane sarcolemma identical protein binding cell projection perikaryon cGMP metabolic process cGMP catabolic process metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity perinuclear region of cytoplasm uc008bva.1 uc008bva.2 uc008bva.3 uc008bva.4 uc008bva.5 
ENSMUST00000047179.7 Zfp598 ENSMUST00000047179.7 zinc finger protein 598, transcript variant 2 (from RefSeq NM_001348231.1) ENSMUST00000047179.1 ENSMUST00000047179.2 ENSMUST00000047179.3 ENSMUST00000047179.4 ENSMUST00000047179.5 ENSMUST00000047179.6 NM_001348231 Q6KAT0 Q80YR4 Q8R3S1 ZN598_MOUSE Zfp598 Znf598 uc008axp.1 uc008axp.2 uc008axp.3 E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains. ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs. Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation. Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and 'Lys-63'-linked polyubiquitination of RPS20/uS10. Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides. E3 ubiquitin-protein ligase activity is dependent on the E2 ubiquitin-conjugating enzyme UBE2D3. Also acts as an adapter that recruits the 4EHP-GYF2 complex to mRNAs. Independently of its role in RQC, may also act as a negative regulator of interferon-stimulated gene (ISG) expression. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with the E2 ubiquitin-conjugating enzyme UBE2D3. Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80YR4-1; Sequence=Displayed; Name=2; IsoId=Q80YR4-2; Sequence=VSP_020667; Name=3; IsoId=Q80YR4-3; Sequence=VSP_020666; Belongs to the ZNF598/HEL2 family. Sequence=BAD21377.1; Type=Erroneous initiation; Evidence=; nucleic acid binding regulation of translation protein monoubiquitination protein ubiquitination transferase activity ribosome binding metal ion binding ubiquitin protein ligase activity rescue of stalled ribosome uc008axp.1 uc008axp.2 uc008axp.3 
ENSMUST00000047194.4 Igsf6 ENSMUST00000047194.4 immunoglobulin superfamily, member 6 (from RefSeq NM_030691.1) ENSMUST00000047194.1 ENSMUST00000047194.2 ENSMUST00000047194.3 IGSF6_MOUSE NM_030691 P0C6B7 uc009jnm.1 uc009jnm.2 uc009jnm.3 Membrane ; Single-pass type I membrane protein Ubiquitous with higher expression in immune tissue. This gene is coded entirely within the intron of Mettl9 which is transcribed in the opposite strand of the DNA. molecular_function cellular_component biological_process membrane integral component of membrane uc009jnm.1 uc009jnm.2 uc009jnm.3 
ENSMUST00000047196.14 Mettl27 ENSMUST00000047196.14 methyltransferase like 27, transcript variant 1 (from RefSeq NM_024479.2) BC002286 ENSMUST00000047196.1 ENSMUST00000047196.10 ENSMUST00000047196.11 ENSMUST00000047196.12 ENSMUST00000047196.13 ENSMUST00000047196.2 ENSMUST00000047196.3 ENSMUST00000047196.4 ENSMUST00000047196.5 ENSMUST00000047196.6 ENSMUST00000047196.7 ENSMUST00000047196.8 ENSMUST00000047196.9 Mettl27 NM_024479 Q8BGM4 Q8BGM4_MOUSE Wbscr27 uc008zwz.1 uc008zwz.2 uc008zwz.3 uc008zwz.1 uc008zwz.2 uc008zwz.3 
ENSMUST00000047199.5 Rdh7 ENSMUST00000047199.5 retinol dehydrogenase 7, transcript variant 2 (from RefSeq NM_017473.4) Crad2 ENSMUST00000047199.1 ENSMUST00000047199.2 ENSMUST00000047199.3 ENSMUST00000047199.4 NM_017473 O88451 RDH7_MOUSE uc007hkv.1 uc007hkv.2 uc007hkv.3 uc007hkv.4 Acts on androgens and retinols, i.e. has steroid 3-alpha- and 17-beta-dehydrogenase and cis/trans-retinol catalytic activities. Reaction=all-trans-retinol--[retinol-binding protein] + NAD(+) = all- trans-retinal--[retinol-binding protein] + H(+) + NADH; Xref=Rhea:RHEA:48488, Rhea:RHEA-COMP:14428, Rhea:RHEA-COMP:14430, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83228; EC=1.1.1.105; Cofactor metabolism; retinol metabolism. Microsome Endoplasmic reticulum Highly expressed in liver. Also expressed in lung, eye, kidney, and brain. Belongs to the short-chain dehydrogenases/reductases (SDR) family. catalytic activity retinol dehydrogenase activity endoplasmic reticulum oxidoreductase activity retinol metabolic process intracellular membrane-bounded organelle oxidation-reduction process uc007hkv.1 uc007hkv.2 uc007hkv.3 uc007hkv.4 
ENSMUST00000047203.9 Rnf126 ENSMUST00000047203.9 ring finger protein 126, transcript variant 1 (from RefSeq NM_144528.3) ENSMUST00000047203.1 ENSMUST00000047203.2 ENSMUST00000047203.3 ENSMUST00000047203.4 ENSMUST00000047203.5 ENSMUST00000047203.6 ENSMUST00000047203.7 ENSMUST00000047203.8 NM_144528 Q91YL2 RN126_MOUSE Rnf126 uc007fzr.1 uc007fzr.2 uc007fzr.3 uc007fzr.4 E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (By similarity). Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (PubMed:23418353). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome (By similarity). Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (By similarity). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (By similarity). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (By similarity). May monoubiquitinate AICDA (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with CCDC50, EGFR, FLT3 and SCAMP3 (PubMed:23418353). Interacts with BAG6 (via ubiquitin-like domain); required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol (By similarity). Interacts with CDKN1A (By similarity). Interacts with AICDA (By similarity). Cytoplasm Nucleus Detected in B-cells (at protein level). Up-regulated in B-cells that undergo class-switch recombination (at protein level). The C4-type zinc finger is required for interaction with BAG6. Ubiquitinated. May undergo autoubiquitination. epidermal growth factor receptor binding protein binding nucleus nucleoplasm cytoplasm cytosol ubiquitin-dependent protein catabolic process protein monoubiquitination protein ubiquitination transferase activity negative regulation of epidermal growth factor receptor signaling pathway regulation of cell proliferation retrograde transport, endosome to Golgi proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway metal ion binding ubiquitin protein ligase activity protein K63-linked ubiquitination protein K48-linked ubiquitination cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process uc007fzr.1 uc007fzr.2 uc007fzr.3 uc007fzr.4 
ENSMUST00000047206.7 Plekhh2 ENSMUST00000047206.7 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2, transcript variant 1 (from RefSeq NM_177606.4) B2RQ85 ENSMUST00000047206.1 ENSMUST00000047206.2 ENSMUST00000047206.3 ENSMUST00000047206.4 ENSMUST00000047206.5 ENSMUST00000047206.6 Kiaa2028 NM_177606 PKHH2_MOUSE Q059P2 Q69Z29 Q8C115 Q8VDL8 uc008dsw.1 uc008dsw.2 uc008dsw.3 uc008dsw.4 In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia. Self-associates. Interacts with TGFB1I1. Q8C115; Q62219: Tgfb1i1; NbExp=3; IntAct=EBI-6512409, EBI-642844; Cytoplasm Cytoplasm, cytoskeleton Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, lamellipodium Note=Localizes to the slit diaphragm and foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent on PI3K (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C115-1; Sequence=Displayed; Name=2; IsoId=Q8C115-2; Sequence=VSP_028576, VSP_028577; Name=3; IsoId=Q8C115-3; Sequence=VSP_028578; Expressed in the kidney and testis. Expressed in the kidney exclusively by glomerular podocytes. Sequence=AAH21518.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; actin binding protein binding nucleoplasm cytoplasm cytosol cytoskeleton plasma membrane membrane nuclear body lamellipodium negative regulation of actin filament depolymerization cortical actin cytoskeleton identical protein binding cell projection uc008dsw.1 uc008dsw.2 uc008dsw.3 uc008dsw.4 
ENSMUST00000047207.7 Ccdc27 ENSMUST00000047207.7 coiled-coil domain containing 27 (from RefSeq NM_001033455.2) CCD27_MOUSE ENSMUST00000047207.1 ENSMUST00000047207.2 ENSMUST00000047207.3 ENSMUST00000047207.4 ENSMUST00000047207.5 ENSMUST00000047207.6 Gm1035 NM_001033455 Q3V036 uc008wbf.1 uc008wbf.2 uc008wbf.3 molecular_function cellular_component biological_process uc008wbf.1 uc008wbf.2 uc008wbf.3 
ENSMUST00000047218.5 Reep4 ENSMUST00000047218.5 receptor accessory protein 4 (from RefSeq NM_180588.2) ENSMUST00000047218.1 ENSMUST00000047218.2 ENSMUST00000047218.3 ENSMUST00000047218.4 NM_180588 Q8K072 REEP4_MOUSE uc007uoi.1 uc007uoi.2 uc007uoi.3 uc007uoi.4 Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the DP1 family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane microtubule nuclear envelope organization cell cycle mitotic nuclear envelope reassembly microtubule binding membrane integral component of membrane cell division uc007uoi.1 uc007uoi.2 uc007uoi.3 uc007uoi.4 
ENSMUST00000047226.10 Lonp1 ENSMUST00000047226.10 lon peptidase 1, mitochondrial (from RefSeq NM_028782.2) ENSMUST00000047226.1 ENSMUST00000047226.2 ENSMUST00000047226.3 ENSMUST00000047226.4 ENSMUST00000047226.5 ENSMUST00000047226.6 ENSMUST00000047226.7 ENSMUST00000047226.8 ENSMUST00000047226.9 LONM_MOUSE NM_028782 Prss15 Q3TSK9 Q3TVL2 Q3TXE4 Q3TZW3 Q8CGK3 Q9DBP9 uc008dcp.1 uc008dcp.2 uc008dcp.3 uc008dcp.4 uc008dcp.5 ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m. MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53; Evidence=; Homohexamer. Organized in a ring with a central cavity. The ATP-binding and proteolytic domains (AP-domain) form a hexameric chamber, while the N-terminal domain is arranged as a trimer of dimers. DNA and RNA binding is stimulated by substrate and inhibited by ATP binding. Interacts with TWNK and mitochondrial DNA polymerase subunit POLG. Mitochondrion matrix Detected in liver > heart > kidney > testis. Belongs to the peptidase S16 family. nucleotide binding mitochondrial RNA polymerase regulatory region DNA binding response to hypoxia DNA binding single-stranded DNA binding single-stranded RNA binding ATP-dependent peptidase activity serine-type endopeptidase activity ATP binding nucleus nucleoplasm mitochondrion mitochondrial matrix cytosol proteolysis misfolded or incompletely synthesized protein catabolic process mitochondrion organization aging peptidase activity serine-type peptidase activity response to hormone response to aluminum ion hydrolase activity ATPase activity protein catabolic process cellular response to oxidative stress cellular macromolecular complex assembly mitochondrial nucleoid ADP binding sequence-specific DNA binding chaperone-mediated protein complex assembly protein homooligomerization proteolysis involved in cellular protein catabolic process G-quadruplex DNA binding DNA polymerase binding oxidation-dependent protein catabolic process uc008dcp.1 uc008dcp.2 uc008dcp.3 uc008dcp.4 uc008dcp.5 
ENSMUST00000047239.13 Pcnx2 ENSMUST00000047239.13 pecanex homolog 2 (from RefSeq NM_175561.4) A2RT20 ENSMUST00000047239.1 ENSMUST00000047239.10 ENSMUST00000047239.11 ENSMUST00000047239.12 ENSMUST00000047239.2 ENSMUST00000047239.3 ENSMUST00000047239.4 ENSMUST00000047239.5 ENSMUST00000047239.6 ENSMUST00000047239.7 ENSMUST00000047239.8 ENSMUST00000047239.9 Kiaa0435 NM_175561 PCX2_MOUSE Pcnx2 Pcnxl2 Q5DU28 Q8BRN0 Q8C2V1 Q8CDD2 uc009nyn.1 uc009nyn.2 uc009nyn.3 May play a role in tumorigenesis. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5DU28-1; Sequence=Displayed; Name=2; IsoId=Q5DU28-2; Sequence=VSP_033613, VSP_033616; Name=3; IsoId=Q5DU28-3; Sequence=VSP_033614, VSP_033615; Name=4; IsoId=Q5DU28-4; Sequence=VSP_033612; Belongs to the pecanex family. molecular_function cellular_component biological_process membrane integral component of membrane uc009nyn.1 uc009nyn.2 uc009nyn.3 
ENSMUST00000047242.9 Traf3ip1 ENSMUST00000047242.9 TRAF3 interacting protein 1 (from RefSeq NM_028718.2) ENSMUST00000047242.1 ENSMUST00000047242.2 ENSMUST00000047242.3 ENSMUST00000047242.4 ENSMUST00000047242.5 ENSMUST00000047242.6 ENSMUST00000047242.7 ENSMUST00000047242.8 Ift54 MIPT3_MOUSE Mipt3 NM_028718 Q149C2 Q538H5 Q80VQ3 Q9CS98 uc007cax.1 uc007cax.2 uc007cax.3 uc007cax.4 Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in epithelial morphogenesis and in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (PubMed:21945076). Interacts with IL13RA1. Binds to microtubules, TRAF3 and DISC1 (By similarity). Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88. Interacts with MAP4 (PubMed:26487268). Cytoplasm, cytoskeleton Cell projection, cilium Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, cilium basal body Note=Microtubules. In the cilium, it is observed at the ciliary base, ciliary transition zone and ciliary tip. Homozygous mutant mice are not viable and have neural development defects, abnormal neural tube patterning, polydactyly, cardiac edema, and variable microphthalmia. Mutant cells have a marked reduction in the number of cilia. Belongs to the TRAF3IP1 family. Sequence=AAH46538.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; negative regulation of transcription from RNA polymerase II promoter morphogenesis of a polarized epithelium kidney development negative regulation of protein phosphorylation receptor binding protein binding cytoplasm centrosome cytosol cytoskeleton cilium axoneme microtubule binding microtubule cytoskeleton tubulin binding neural tube patterning cell projection organization intraciliary transport particle B embryonic camera-type eye development negative regulation of protein complex assembly negative regulation of type I interferon production negative regulation of interferon-beta production embryonic heart tube development ciliary transition zone ciliary basal body post-anal tail morphogenesis intraciliary transport negative regulation of tyrosine phosphorylation of STAT protein embryonic digit morphogenesis cell projection negative regulation of defense response to virus regulation of DNA binding cilium assembly regulation of microtubule cytoskeleton organization ciliary tip ciliary base negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning uc007cax.1 uc007cax.2 uc007cax.3 uc007cax.4 
ENSMUST00000047243.12 Rap1gap ENSMUST00000047243.12 Rap1 GTPase-activating protein, transcript variant 9 (from RefSeq NM_001379235.1) A2ALS5 E9PZZ8 ENSMUST00000047243.1 ENSMUST00000047243.10 ENSMUST00000047243.11 ENSMUST00000047243.2 ENSMUST00000047243.3 ENSMUST00000047243.4 ENSMUST00000047243.5 ENSMUST00000047243.6 ENSMUST00000047243.7 ENSMUST00000047243.8 ENSMUST00000047243.9 Kiaa0474 NM_001379235 Q6A063 Q80VZ8 Q8K2L6 RPGP1_MOUSE Rap1ga1 uc008vjn.1 uc008vjn.2 uc008vjn.3 uc008vjn.4 GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP- bound state. Homodimer and heterodimer with RAP1B. Golgi apparatus membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=A2ALS5-1; Sequence=Displayed; Name=2; IsoId=A2ALS5-2; Sequence=VSP_053560; Name=3; IsoId=A2ALS5-3; Sequence=VSP_053561; Name=4; IsoId=A2ALS5-4; Sequence=VSP_053562; Detected in brain cortex and striatum (at protein level). Detected in brain cortex and striatum. Sequence=AAH52065.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32233.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane GTPase activator activity protein binding early endosome Golgi apparatus cytosol membrane Ras GTPase binding positive regulation of cell-cell adhesion axon dendrite GTPase regulator activity protein homodimerization activity neuronal cell body regulation of GTPase activity positive regulation of GTPase activity negative regulation of neuron differentiation positive regulation of phagocytosis regulation of small GTPase mediated signal transduction negative regulation of microvillus assembly negative regulation of GTP binding negative regulation of thyroid gland epithelial cell proliferation cellular response to glial cell derived neurotrophic factor uc008vjn.1 uc008vjn.2 uc008vjn.3 uc008vjn.4 
ENSMUST00000047247.12 Hectd2 ENSMUST00000047247.12 HECT domain E3 ubiquitin protein ligase 2, transcript variant 2 (from RefSeq NM_172637.3) E9QK99 ENSMUST00000047247.1 ENSMUST00000047247.10 ENSMUST00000047247.11 ENSMUST00000047247.2 ENSMUST00000047247.3 ENSMUST00000047247.4 ENSMUST00000047247.5 ENSMUST00000047247.6 ENSMUST00000047247.7 ENSMUST00000047247.8 ENSMUST00000047247.9 HECD2_MOUSE NM_172637 Q8CBQ9 Q8CDU6 uc008hho.1 uc008hho.2 uc008hho.3 uc008hho.4 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence=; Protein modification; protein ubiquitination. Sequence=BAC29085.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ubiquitin-protein transferase activity protein ubiquitination transferase activity uc008hho.1 uc008hho.2 uc008hho.3 uc008hho.4 
ENSMUST00000047257.15 Katnal1 ENSMUST00000047257.15 katanin p60 subunit A-like 1 (from RefSeq NM_153572.2) ENSMUST00000047257.1 ENSMUST00000047257.10 ENSMUST00000047257.11 ENSMUST00000047257.12 ENSMUST00000047257.13 ENSMUST00000047257.14 ENSMUST00000047257.2 ENSMUST00000047257.3 ENSMUST00000047257.4 ENSMUST00000047257.5 ENSMUST00000047257.6 ENSMUST00000047257.7 ENSMUST00000047257.8 ENSMUST00000047257.9 KATL1_MOUSE NM_153572 Q8K0T4 uc033inw.1 uc033inw.2 uc033inw.3 Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (PubMed:22654668). Has microtubule- severing activity in vitro (By similarity). Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence=; Interacts with KATNB1 and KATNBL1. Cytoplasm, cytoskeleton toplasm Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, spindle Note=Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (PubMed:22654668). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (By similarity). Widely expressed, including in testis, brain, heart, lung, kidney, liver, spleen, seminal vesicles and ovary. In testis, restricted to Sertoli cells within the seminiferous epithelium (at protein level). Expressed in Sertoli cells from 15.5 dpc onwards (at protein level). Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily. nucleotide binding spindle pole ATP binding nucleus cytoplasm centrosome spindle cytoskeleton microtubule spermatogenesis microtubule binding microtubule-severing ATPase activity microtubule cytoskeleton isomerase activity ATPase activity cytoplasmic microtubule organization identical protein binding microtubule severing uc033inw.1 uc033inw.2 uc033inw.3 
ENSMUST00000047264.3 Sprr2i ENSMUST00000047264.3 small proline-rich protein 2I (from RefSeq NM_011475.4) ENSMUST00000047264.1 ENSMUST00000047264.2 NM_011475 O70560 SPR2I_MOUSE uc008qdy.1 uc008qdy.2 Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). Cytoplasm Not expressed in uterus. Belongs to the cornifin (SPRR) family. cornified envelope cytoplasm epidermis development keratinocyte differentiation keratinization uc008qdy.1 uc008qdy.2 
ENSMUST00000047265.13 Saxo5 ENSMUST00000047265.13 stabilizer of axonemal microtubules 5 (from RefSeq NM_029598.1) 1700019B03Rik ENSMUST00000047265.1 ENSMUST00000047265.10 ENSMUST00000047265.11 ENSMUST00000047265.12 ENSMUST00000047265.2 ENSMUST00000047265.3 ENSMUST00000047265.4 ENSMUST00000047265.5 ENSMUST00000047265.6 ENSMUST00000047265.7 ENSMUST00000047265.8 ENSMUST00000047265.9 G3XA23 G3XA23_MOUSE NM_029598 Saxo5 Tex45 uc012fyj.1 uc012fyj.2 molecular_function cellular_component biological_process uc012fyj.1 uc012fyj.2 
ENSMUST00000047273.3 Rpusd1 ENSMUST00000047273.3 RNA pseudouridylate synthase domain containing 1, transcript variant 1 (from RefSeq NM_028009.4) ENSMUST00000047273.1 ENSMUST00000047273.2 NM_028009 Q8VCZ8 RUSD1_MOUSE Rlucl uc008bbl.1 uc008bbl.2 uc008bbl.3 Belongs to the pseudouridine synthase RluA family. enzyme-directed rRNA pseudouridine synthesis pseudouridine synthesis RNA binding RNA modification pseudouridine synthase activity uc008bbl.1 uc008bbl.2 uc008bbl.3 
ENSMUST00000047275.8 Bace2 ENSMUST00000047275.8 beta-site APP-cleaving enzyme 2 (from RefSeq NM_019517.5) A0A0R4J0I8 A0A0R4J0I8_MOUSE Bace2 ENSMUST00000047275.1 ENSMUST00000047275.2 ENSMUST00000047275.3 ENSMUST00000047275.4 ENSMUST00000047275.5 ENSMUST00000047275.6 ENSMUST00000047275.7 NM_019517 uc008ade.1 uc008ade.2 uc008ade.3 uc008ade.4 This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein undergoes proteolytic processing to generate an active endopeptidase enzyme. This transmembrane protease catalyzes the proteolysis of amyloid precursor protein to produce amyloid beta peptide. Mice lacking the encoded product exhibit increased pancreatic beta cell mass and improved glucose tolerance due to increased insulin secretion. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK078770.1, BC120773.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Endoplasmic reticulum Endosome Membrane ; Single-pass type I membrane protein Belongs to the peptidase A1 family. aspartic-type endopeptidase activity cytoplasm Golgi apparatus plasma membrane proteolysis membrane protein ectodomain proteolysis peptidase activity membrane integral component of membrane hydrolase activity dense core granule glucose homeostasis negative regulation of amyloid precursor protein biosynthetic process astrocyte activation uc008ade.1 uc008ade.2 uc008ade.3 uc008ade.4 
ENSMUST00000047281.10 Trir ENSMUST00000047281.10 telomerase RNA component interacting RNase, transcript variant 2 (from RefSeq NR_160793.1) ENSMUST00000047281.1 ENSMUST00000047281.2 ENSMUST00000047281.3 ENSMUST00000047281.4 ENSMUST00000047281.5 ENSMUST00000047281.6 ENSMUST00000047281.7 ENSMUST00000047281.8 ENSMUST00000047281.9 NR_160793 Q9D1N3 Q9D735 TRIR_MOUSE Trir uc009moy.1 uc009moy.2 uc009moy.3 Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (By similarity). Part of the telomerase RNA 3' end complex which contains about 488 proteins (By similarity). The C-terminus contains a key domain which is responsible for the RNA digestion activity (By similarity). RNA binding nuclease activity exonuclease activity cellular_component 3'-5' exonuclease activity 5'-3' exonuclease activity rRNA catabolic process hydrolase activity RNA phosphodiester bond hydrolysis, exonucleolytic uc009moy.1 uc009moy.2 uc009moy.3 
ENSMUST00000047309.6 Nat14 ENSMUST00000047309.6 N-acetyltransferase 14, transcript variant 1 (from RefSeq NM_201355.3) ENSMUST00000047309.1 ENSMUST00000047309.2 ENSMUST00000047309.3 ENSMUST00000047309.4 ENSMUST00000047309.5 NAT14_MOUSE NM_201355 Q8BVG8 uc009eyy.1 uc009eyy.2 uc009eyy.3 Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro (By similarity). Probable acetyltransferase. May act as a transcription factor regulating the expression of coproporphyrinogen oxidase by binding to a promoter regulatory element. Membrane ; Single-pass membrane protein Belongs to the camello family. molecular_function DNA binding cellular_component N-acetyltransferase activity biological_process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups uc009eyy.1 uc009eyy.2 uc009eyy.3 
ENSMUST00000047311.16 Mboat1 ENSMUST00000047311.16 membrane bound O-acyltransferase domain containing 1, transcript variant 6 (from RefSeq NR_184863.1) A9EDS0 ENSMUST00000047311.1 ENSMUST00000047311.10 ENSMUST00000047311.11 ENSMUST00000047311.12 ENSMUST00000047311.13 ENSMUST00000047311.14 ENSMUST00000047311.15 ENSMUST00000047311.2 ENSMUST00000047311.3 ENSMUST00000047311.4 ENSMUST00000047311.5 ENSMUST00000047311.6 ENSMUST00000047311.7 ENSMUST00000047311.8 ENSMUST00000047311.9 Lpeat1 MBOA1_MOUSE Mboat1 NR_184863 Oact1 Q8BH98 Q8R3T2 uc007pyt.1 uc007pyt.2 uc007pyt.3 Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18287005). Acts on lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) and lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE), and to a lesser extend lysophosphatidylcholine (PubMed:18287005). Prefers oleoyl-CoA as the acyl donor and 1-oleoyl-LPE as acceptor (PubMed:18287005). May play a role in neurite outgrowth during neuronal differentiation (PubMed:27048541). Reaction=a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:32995, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64381, ChEBI:CHEBI:64612; EC=2.3.1.n7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32996; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2- diacyl-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:33191, ChEBI:CHEBI:57262, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64379; EC=2.3.1.n6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33192; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2- diacyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:12937, ChEBI:CHEBI:57287, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:58342; EC=2.3.1.23; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12938; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3- phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn- glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37631, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:77288, ChEBI:CHEBI:77291; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37632; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3- phosphoethanolamine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero- 3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37523, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75036, ChEBI:CHEBI:75038; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37524; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phospho-L-serine = 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L- serine + CoA; Xref=Rhea:RHEA:37407, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74617, ChEBI:CHEBI:74905; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37408; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + CoA; Xref=Rhea:RHEA:37499, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74971, ChEBI:CHEBI:74986; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37500; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphoethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero- 3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:36015, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:73004, ChEBI:CHEBI:73007; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36016; Evidence=; Reaction=1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3- phosphoethanolamine + CoA; Xref=Rhea:RHEA:65128, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:149768, ChEBI:CHEBI:156345; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65129; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3- phospho-L-serine + CoA; Xref=Rhea:RHEA:37403, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:74617, ChEBI:CHEBI:74902; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37404; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn- glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37399, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:74617, ChEBI:CHEBI:74901; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37400; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero- 3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn- glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37375, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74617, ChEBI:CHEBI:74892; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37376; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:35991, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35992; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3- phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn- glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:65136, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:149768, ChEBI:CHEBI:156344; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65137; Evidence=; Kinetic parameters: KM=4.7 uM for oleoyl-CoA (in the presence of LPE C18:1 as cosubstrate) ; KM=3.9 uM for oleoyl-CoA (in the presence of LPS C18:1 as cosubstrate) ; KM=7.75 uM for LPE C18:1 (in the presence of oleoyl-CoA as cosubstrate) ; KM=2.25 uM for LPS C18:1 (in the presence of oleoyl-CoA as cosubstrate) ; Vmax=9.125 nmol/min/mg enzyme with oleoyl-CoA and LPE C18:1 as substrates ; Vmax=4.7 nmol/min/mg enzyme with oleoyl-CoA and LPS C18:1 as substrates ; Lipid metabolism; phospholipid metabolism. Membrane ; Multi-pass membrane protein Endoplasmic reticulum Highly expressed in stomach, epididymis, and colon. Belongs to the membrane-bound acyltransferase family. molecular_function cellular_component endoplasmic reticulum lipid metabolic process phospholipid metabolic process biological_process phospholipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups uc007pyt.1 uc007pyt.2 uc007pyt.3 
ENSMUST00000047321.9 Bmal1 ENSMUST00000047321.9 basic helix-loop-helix ARNT like 1, transcript variant 13 (from RefSeq NR_177991.1) Arntl BMAL1_MOUSE ENSMUST00000047321.1 ENSMUST00000047321.2 ENSMUST00000047321.3 ENSMUST00000047321.4 ENSMUST00000047321.5 ENSMUST00000047321.6 ENSMUST00000047321.7 ENSMUST00000047321.8 NR_177991 O88295 Q921S4 Q9R0U2 Q9WTL8 Q9WTL9 uc009jhe.1 uc009jhe.2 uc009jhe.3 Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post- translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. May play a role in spermatogenesis; contributes to the chromatoid body assembly and physiology. The NPAS2- BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (By similarity). CLOCK specifically binds to the half-site 5'- CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (By similarity). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (By similarity). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (PubMed:29996098). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (PubMed:30096135). The redox state of the cell can modulate the transcriptional activity of the CLOCK-BMAL1 and NPAS2-BMAL1 heterodimers; NADH and NADPH enhance the DNA-binding activity of the heterodimers. Component of the circadian clock oscillator which includes the CRY1/2 proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER1/2/3 proteins (PubMed:11779462). Forms a heterodimer with CLOCK (PubMed:9616112, PubMed:16717091, PubMed:16980631, PubMed:18662546, PubMed:19946213, PubMed:19330005, PubMed:21613214, PubMed:23970558, PubMed:22653727). The CLOCK-BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and BMAL1 (PubMed:11779462). Part of a nuclear complex which also includes RACK1 and PRKCA; RACK1 and PRKCA are recruited to the complex in a circadian manner (PubMed:20093473). Interacts with NPAS2 (PubMed:16628007). Interacts with EZH2 (PubMed:16717091, PubMed:23970558). Interacts with SUMO3 (PubMed:18644859). Interacts with SIRT1 (PubMed:18662546, PubMed:18662547, PubMed:19299583). Interacts with AHR (PubMed:20106950). Interacts with ID1, ID2 and ID3 (PubMed:20861012). Interacts with DDX4 (PubMed:22900038). Interacts with OGT (PubMed:23337503). Interacts with EED and SUZ12 (PubMed:23970558). Interacts with MTA1 (PubMed:24089055). Interacts with CIART (PubMed:24385426, PubMed:24736997). Interacts with HSP90 (By similarity). Interacts with KAT2B and EP300 (By similarity). Interacts with BHLHE40/DEC1 and BHLHE41/DEC2 (PubMed:12397359). Interacts with RELB and the interaction is enhanced in the presence of CLOCK (PubMed:22894897). Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus (PubMed:18430226, PubMed:19605937, PubMed:20840750, PubMed:21613214, PubMed:24154698). Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation (PubMed:21613214). Interaction of the CLOCK- BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA (PubMed:21613214). The CLOCK-BMAL1 heterodimer interacts with GSK3B (PubMed:19946213, PubMed:20049328). Interacts with KDM5A (PubMed:21960634). Interacts with KMT2A; in a circadian manner (PubMed:21113167). Interacts with UBE3A (By similarity). Interacts with PRKCG (PubMed:23185022). Interacts with MAGEL2 (PubMed:22208286). Interacts with NCOA2 (PubMed:24529706). Interacts with THRAP3 (PubMed:24043798). The CLOCK-BMAL1 heterodimer interacts with PASD1 (By similarity). Interacts with PASD1 (By similarity). Interacts with USP9X (PubMed:29626158). Interacts with PIWIL2 (via PIWI domain) (PubMed:28903391). Interacts with HDAC3 (PubMed:26776516). Interacts with HNF4A (By similarity). Q9WTL8; Q3TQ03: Ciart; NbExp=3; IntAct=EBI-644534, EBI-16101489; Q9WTL8; O08785: Clock; NbExp=39; IntAct=EBI-644534, EBI-79859; Q9WTL8; P97784: Cry1; NbExp=23; IntAct=EBI-644534, EBI-1266607; Q9WTL8; Q99JJ1: Cry2; NbExp=4; IntAct=EBI-644534, EBI-1794634; Q9WTL8; Q9R194: Cry2; NbExp=12; IntAct=EBI-644534, EBI-1266619; Q9WTL8; Q60737: Csnk2a1; NbExp=5; IntAct=EBI-644534, EBI-771698; Q9WTL8; P67871: Csnk2b; NbExp=8; IntAct=EBI-644534, EBI-348179; Q9WTL8; P11103: Parp1; NbExp=7; IntAct=EBI-644534, EBI-642213; Q9WTL8; O54943: Per2; NbExp=9; IntAct=EBI-644534, EBI-1266779; Q9WTL8; P62137: Ppp1ca; NbExp=2; IntAct=EBI-644534, EBI-357187; Q9WTL8; Q8N365: CIART; Xeno; NbExp=6; IntAct=EBI-644534, EBI-10265133; Q9WTL8; P67870: CSNK2B; Xeno; NbExp=4; IntAct=EBI-644534, EBI-348169; Q9WTL8; Q03164: KMT2A; Xeno; NbExp=3; IntAct=EBI-644534, EBI-591370; Q9WTL8; P51449: RORC; Xeno; NbExp=2; IntAct=EBI-644534, EBI-3908771; Q9WTL8; P61964: WDR5; Xeno; NbExp=2; IntAct=EBI-644534, EBI-540834; Q9WTL8-2; O08785: Clock; NbExp=2; IntAct=EBI-644559, EBI-79859; Q9WTL8-2; P97784: Cry1; NbExp=4; IntAct=EBI-644559, EBI-1266607; Q9WTL8-4; O08785: Clock; NbExp=10; IntAct=EBI-644568, EBI-79859; Q9WTL8-4; P45481: Crebbp; NbExp=2; IntAct=EBI-644568, EBI-296306; Q9WTL8-4; P97784: Cry1; NbExp=4; IntAct=EBI-644568, EBI-1266607; Nucleus toplasm Nucleus, PML body Note=Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2. Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=b'; IsoId=Q9WTL8-1; Sequence=Displayed; Name=2; Synonyms=b; IsoId=Q9WTL8-2; Sequence=VSP_007992; Name=3; IsoId=Q9WTL8-3; Sequence=VSP_007993, VSP_007994; Name=4; IsoId=Q9WTL8-4; Sequence=VSP_007992, VSP_007994; Name=5; Synonyms=g'; IsoId=Q9WTL8-5; Sequence=VSP_007992, VSP_007995, VSP_007996; Expressed in liver and testis (at protein level). Expressed in the suprachiasmatic nucleus (SCN) in a circadian manner (PubMed:29138967). Expressed in a circadian manner in the liver. Ubiquitinated, leading to its proteasomal degradation (PubMed:16980631, PubMed:18644859, PubMed:23185022, PubMed:26776516). Deubiquitinated by USP9X (PubMed:29626158). O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-BMAL1 heterodimer thereby increasing CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2/3 and CRY1/2. Acetylated on Lys-544 by CLOCK during the repression phase of the circadian cycle (PubMed:18075593, PubMed:31294688). Acetylation facilitates recruitment of CRY1 protein and initiates the repression phase of the circadian cycle (PubMed:18075593). Acetylated at Lys-544 by KAT5 during the activation phase of the cycle, leading to recruitment of the positive transcription elongation factor b (P-TEFb) and BRD4, followed by productive elongation of circadian transcripts (PubMed:31294688). Deacetylated by SIRT1, which may result in decreased protein stability (PubMed:18662547). Phosphorylated upon dimerization with CLOCK. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the CLOCK-BMAL1 heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver with a peak between CT10 to CT14. Phosphorylation at Ser-97 by CK2 is essential for its nuclear localization, its interaction with CLOCK and controls CLOCK nuclear entry. Dephosphorylation at Ser-85 is important for dimerization with CLOCK and transcriptional activity (By similarity). Sumoylated on Lys-266 upon dimerization with CLOCK. Predominantly conjugated to poly-SUMO2/3 rather than SUMO1 and the level of these conjugates undergo rhythmic variation, peaking at CT9-CT12. Sumoylation localizes it exclusively to the PML body and promotes its ubiquitination in the PML body, ubiquitin-dependent proteasomal degradation and the transcriptional activity of the CLOCK-BMAL1 heterodimer. Undergoes lysosome-mediated degradation in a time-dependent manner in the liver. Mice are characterized by reduced lifespan, and the presence of a number of pathologies characteristic of pre-mature aging and increased oxidative stress. They show impaired functional connectivity, increased oxidative damage and severe astrogliosis in the brain. They also exhibit accelerated thrombosis with elevated levels of thrombogenic factors, including VWF, SERPINE1/PAI1, and fibrinogen. Both male and female mice are infertile and male mice have low testosterone and high luteinizing hormone serum levels and a significant decrease in sperm count (PubMed:18258755, PubMed:22101268, PubMed:24270424, PubMed:24481314). Conditional knockout in myeloid cells increases the risk of sepsis lethality which is associated with elevated lactate production and CD274 expression in macrophages (PubMed:29996098). Myeloid-cell-specific BMAL1 and PKM2 double knockout reduces the risk of sepsis lethality which is associated with reduced serum lactate levels and reduced CD274 expression in macrophages (PubMed:29996098). Conditional knockout in skeletal muscle leads to impaired skeletal muscle triglyceride biosynthesis, accumulation of bioactive lipids and amino acids and reduced mitochondrial efficiency (PubMed:30096135). transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated protein import into nucleus spermatogenesis circadian rhythm transcription factor binding nuclear body PML body aryl hydrocarbon receptor binding negative regulation of TOR signaling circadian regulation of gene expression chromatoid body regulation of protein catabolic process regulation of hair cycle positive regulation of circadian rhythm proteasome-mediated ubiquitin-dependent protein catabolic process intracellular membrane-bounded organelle bHLH transcription factor binding sequence-specific DNA binding negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity rhythmic process regulation of neurogenesis regulation of insulin secretion regulation of cell cycle response to redox state Hsp90 protein binding maternal process involved in parturition repressing transcription factor binding E-box binding positive regulation of canonical Wnt signaling pathway oxidative stress-induced premature senescence positive regulation of protein acetylation regulation of type B pancreatic cell development negative regulation of glucocorticoid receptor signaling pathway regulation of cellular senescence positive regulation of skeletal muscle cell differentiation uc009jhe.1 uc009jhe.2 uc009jhe.3 
ENSMUST00000047328.11 Igfbp2 ENSMUST00000047328.11 insulin-like growth factor binding protein 2, transcript variant 1 (from RefSeq NM_008342.4) ENSMUST00000047328.1 ENSMUST00000047328.10 ENSMUST00000047328.2 ENSMUST00000047328.3 ENSMUST00000047328.4 ENSMUST00000047328.5 ENSMUST00000047328.6 ENSMUST00000047328.7 ENSMUST00000047328.8 ENSMUST00000047328.9 IBP2_MOUSE Igfbp-2 NM_008342 P47877 Q61722 Q91VK7 uc007bkw.1 uc007bkw.2 uc007bkw.3 uc007bkw.4 uc007bkw.5 The protein encoded by this gene is one of several similar proteins that bind insulin-like growth factors I and II (Igf-I and Igf-II). The encoded protein can be secreted into the bloodstream, where it binds Igf-I and Igf-II with high affinity, or it can remain intracellular, interacting with many different ligands. Two transcript variants, one encoding a secreted isoform and the other encoding a nonsecreted isoform, have been found for this gene. [provided by RefSeq, Sep 2015]. Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Binds IGF2 more than IGF1. Secreted. Highly expressed in adult liver, but also in kidney, lung, brain, spleen, testis and ovary. Expressed embryos at day 11.5. Also expressed in fetal livers with expression increasing dramatically after birth. Expression decreases only slightly after postnatal day 3 and remains abundant thereafter. The C-terminus is required for IGF-binding and growth inhibition. O-glycosylated. insulin-like growth factor binding extracellular region extracellular space signal transduction female pregnancy aging response to nutrient response to mechanical stimulus response to lithium ion apical plasma membrane growth factor binding cytoplasmic vesicle insulin-like growth factor I binding insulin-like growth factor II binding response to estradiol response to retinoic acid cellular response to hormone stimulus regulation of growth positive regulation of activated T cell proliferation response to drug regulation of insulin-like growth factor receptor signaling pathway response to estrogen response to steroid hormone response to glucocorticoid uc007bkw.1 uc007bkw.2 uc007bkw.3 uc007bkw.4 uc007bkw.5 
ENSMUST00000047331.8 Lgi3 ENSMUST00000047331.8 leucine-rich repeat LGI family, member 3, transcript variant 3 (from RefSeq NR_189573.1) ENSMUST00000047331.1 ENSMUST00000047331.2 ENSMUST00000047331.3 ENSMUST00000047331.4 ENSMUST00000047331.5 ENSMUST00000047331.6 ENSMUST00000047331.7 LGI3_MOUSE NR_189573 Q8K406 uc007uoh.1 uc007uoh.2 uc007uoh.3 uc007uoh.4 May participate in the regulation of neuronal exocytosis. Interacts with STX1A. Secreted Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Synapse, synaptosome Cell projection, axon Note=Found in the synaptosomal membrane fraction. Within peripheral myelinated axons, LGI3 is highly expressed at the juxtaparanodal membrane and colocalizes with the voltage-gated potassium channels Kv1.1 (KCNA1) and Kv1.2 (KCNA2), and CNTNAP2, DLG4, ADAM22 and ADAM23 (PubMed:35948005). Brain. LGI3-null mice are fertile, have a normal lifespan, and do not show obvious behavioral abnormalities. They show strongly reduced expression and mislocalization of Kv1 channel complexes that infringe on the paranodal domain. Kv1 channel complexes mislocalization is further exacerbated following nerve injury, as Kv1 complexes are confined to the paranodal domain in remyelinated axons. catalytic activity protein binding extracellular region exocytosis synaptic vesicle regulation of exocytosis cell junction cytoplasmic vesicle neuron projection synapse uc007uoh.1 uc007uoh.2 uc007uoh.3 uc007uoh.4 
ENSMUST00000047334.10 Kcnj1 ENSMUST00000047334.10 potassium inwardly-rectifying channel, subfamily J, member 1, transcript variant 2 (from RefSeq NM_019659.3) ENSMUST00000047334.1 ENSMUST00000047334.2 ENSMUST00000047334.3 ENSMUST00000047334.4 ENSMUST00000047334.5 ENSMUST00000047334.6 ENSMUST00000047334.7 ENSMUST00000047334.8 ENSMUST00000047334.9 KCNJ1_MOUSE NM_019659 O88335 uc009orx.1 uc009orx.2 uc009orx.3 uc009orx.4 uc009orx.5 In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium (By similarity). Inhibited by WNK3. Interacts with SGK1 and SLC9A3R2/NHERF2. Cell membrane ; Multi-pass membrane protein Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced.; Name=1; IsoId=O88335-1; Sequence=Displayed; Phosphorylation at Ser-25 by SGK1 is necessary for its expression at the cell membrane. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily. nucleotide binding kidney development tissue homeostasis inward rectifier potassium channel activity voltage-gated ion channel activity ATP binding phosphatidylinositol-4,5-bisphosphate binding plasma membrane ion transport potassium ion transport post-embryonic development ATP-activated inward rectifier potassium channel activity membrane integral component of membrane potassium ion binding regulation of ion transmembrane transport peptide binding negative regulation of apoptotic process renal sodium ion absorption cellular response to magnesium ion cardiovascular system development regulation of G-protein activated inward rectifier potassium channel activity potassium ion import across plasma membrane uc009orx.1 uc009orx.2 uc009orx.3 uc009orx.4 uc009orx.5 
ENSMUST00000047348.11 Spag1 ENSMUST00000047348.11 sperm associated antigen 1, transcript variant 7 (from RefSeq NR_153381.1) ENSMUST00000047348.1 ENSMUST00000047348.10 ENSMUST00000047348.2 ENSMUST00000047348.3 ENSMUST00000047348.4 ENSMUST00000047348.5 ENSMUST00000047348.6 ENSMUST00000047348.7 ENSMUST00000047348.8 ENSMUST00000047348.9 NR_153381 Q80ZX8 Q8CCK7 Q9QZJ3 Q9QZJ4 SPAG1_MOUSE Tpis uc007vmo.1 uc007vmo.2 uc007vmo.3 May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity (By similarity). Cytoplasm Dynein axonemal particle Note=Colocalizes with tubulin. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80ZX8-1; Sequence=Displayed; Name=2; IsoId=Q80ZX8-2; Sequence=VSP_012684; Name=3; IsoId=Q80ZX8-3; Sequence=VSP_012685; Detected in cerebellum, tongue, esophagus, forestomach, sperm and testis. Expression is very low in embryonic epidermis at 13.5 dpc and increases from 14.5 dpc to 16.5 dpc. In young mice expression increases in the testis of 2 to 6 weeks old animals, and then remains stable. Antibodies against SPAG1 interfere with fertilization. Sequence=BAC27944.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding GTP binding cytoplasm cytosol single fertilization hydrolase activity axonemal dynein complex assembly uc007vmo.1 uc007vmo.2 uc007vmo.3 
ENSMUST00000047349.8 Usp28 ENSMUST00000047349.8 ubiquitin specific peptidase 28, transcript variant 1 (from RefSeq NM_175482.3) ENSMUST00000047349.1 ENSMUST00000047349.2 ENSMUST00000047349.3 ENSMUST00000047349.4 ENSMUST00000047349.5 ENSMUST00000047349.6 ENSMUST00000047349.7 Kiaa1515 NM_175482 Q5I043 Q6NZP3 Q6ZPP1 Q8BWI1 UBP28_MOUSE uc009pir.1 uc009pir.2 uc009pir.3 Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBXW7) complex. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Interacts with ZNF304. Interacts with PRKD1. Interacts with TP53BP1. Interacts with FBXW7; following DNA damage, dissociates from FBXW7 leading to degradation of MYC. Nucleus, nucleoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5I043-1; Sequence=Displayed; Name=2; IsoId=Q5I043-2; Sequence=VSP_015581; Degraded upon nickel ion level or hypoxia exposure. Phosphorylated upon DNA damage at Ser-67 and Ser-720, by ATM or ATR. Phosphorylated by PRKD1. Belongs to the peptidase C19 family. USP28 subfamily. DNA damage checkpoint cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus nucleoplasm DNA repair proteolysis ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus Ras protein signal transduction peptidase activity cysteine-type peptidase activity cell proliferation response to ionizing radiation protein deubiquitination nuclear body hydrolase activity regulation of protein stability macromolecular complex cellular response to UV thiol-dependent ubiquitinyl hydrolase activity intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator uc009pir.1 uc009pir.2 uc009pir.3 
ENSMUST00000047356.11 Atf5 ENSMUST00000047356.11 activating transcription factor 5, transcript variant 2 (from RefSeq NR_033136.1) Atf5 ENSMUST00000047356.1 ENSMUST00000047356.10 ENSMUST00000047356.2 ENSMUST00000047356.3 ENSMUST00000047356.4 ENSMUST00000047356.5 ENSMUST00000047356.6 ENSMUST00000047356.7 ENSMUST00000047356.8 ENSMUST00000047356.9 NR_033136 Q3UJF3 Q3UJF3_MOUSE uc012fju.1 uc012fju.2 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Belongs to the bZIP family. RNA polymerase II regulatory region sequence-specific DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm centrosome cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter negative regulation of cell proliferation tubulin binding kinase binding negative regulation of apoptotic process fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of centrosome cycle negative regulation of cell cycle G2/M phase transition uc012fju.1 uc012fju.2 
ENSMUST00000047357.10 Cpsf2 ENSMUST00000047357.10 cleavage and polyadenylation specific factor 2 (from RefSeq NM_016856.3) CPSF2_MOUSE Cpsf100 ENSMUST00000047357.1 ENSMUST00000047357.2 ENSMUST00000047357.3 ENSMUST00000047357.4 ENSMUST00000047357.5 ENSMUST00000047357.6 ENSMUST00000047357.7 ENSMUST00000047357.8 ENSMUST00000047357.9 Mcpsf NM_016856 O35218 uc007otx.1 uc007otx.2 uc007otx.3 uc007otx.4 Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing (By similarity). Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with CPSF3, CSTF2 and SYMPK (By similarity). Interacts with ZC3H3 (PubMed:16115198). Nucleus Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily. molecular_function RNA binding nucleus mRNA cleavage and polyadenylation specificity factor complex mRNA polyadenylation mRNA cleavage mRNA processing mRNA 3'-end processing by stem-loop binding and cleavage uc007otx.1 uc007otx.2 uc007otx.3 uc007otx.4 
ENSMUST00000047362.11 Rccd1 ENSMUST00000047362.11 Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta- induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8. (from UniProt Q8BTU7) AK030872 ENSMUST00000047362.1 ENSMUST00000047362.10 ENSMUST00000047362.2 ENSMUST00000047362.3 ENSMUST00000047362.4 ENSMUST00000047362.5 ENSMUST00000047362.6 ENSMUST00000047362.7 ENSMUST00000047362.8 ENSMUST00000047362.9 Q6IS64 Q8BJF2 Q8BTU7 Q8C0K3 RCCD1_MOUSE uc009ial.1 uc009ial.2 uc009ial.3 uc009ial.4 Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta- induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8. Found in a complex with KDM8. Interacts (via N-terminus) with KDM8 (via N-terminus). Chromosome Note=Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BTU7-1; Sequence=Displayed; Name=2; IsoId=Q8BTU7-2; Sequence=VSP_034012; Specifically hydroxylated (with R stereochemistry) at C-3 of ARG- 141 by KDM8. molecular_function chromosome cytosol plasma membrane chromatin organization biological_process uc009ial.1 uc009ial.2 uc009ial.3 uc009ial.4 
ENSMUST00000047368.8 Mnd1 ENSMUST00000047368.8 meiotic nuclear divisions 1, transcript variant 1 (from RefSeq NM_029797.4) ENSMUST00000047368.1 ENSMUST00000047368.2 ENSMUST00000047368.3 ENSMUST00000047368.4 ENSMUST00000047368.5 ENSMUST00000047368.6 ENSMUST00000047368.7 MND1_MOUSE Mnd1 NM_029797 Q8K396 Q9D0A1 uc008ppv.1 uc008ppv.2 uc008ppv.3 uc008ppv.4 Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double- strand breaks. Heterodimer with PSMC3IP/HOP2. MND1-PSMC3IP interacts with DMC1 and RAD51 and binds to ssDNA and dsDNA showing no preference for either form of DNA. Nucleus Belongs to the MND1 family. DNA binding double-stranded DNA binding protein binding nucleus DNA recombination reciprocal meiotic recombination meiotic cell cycle uc008ppv.1 uc008ppv.2 uc008ppv.3 uc008ppv.4 
ENSMUST00000047370.3 Sptlc3 ENSMUST00000047370.3 Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. (from UniProt Q8BG54) AK078686 ENSMUST00000047370.1 ENSMUST00000047370.2 Q505L2 Q8BG54 SPTC3_MOUSE Sptlc2l Sptlc3 uc008mpe.1 uc008mpe.2 Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Reaction=H(+) + hexadecanoyl-CoA + L-serine = 3-oxosphinganine + CO2 + CoA; Xref=Rhea:RHEA:14761, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:58299; EC=2.3.1.50; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14762; Evidence=; Reaction=dodecanoyl-CoA + H(+) + L-serine = 3-oxotetradecasphinganine + CO2 + CoA; Xref=Rhea:RHEA:35679, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:71008; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35680; Evidence=; Reaction=H(+) + L-serine + tetradecanoyl-CoA = 3-oxohexadecasphinganine + CO2 + CoA; Xref=Rhea:RHEA:35675, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:71007; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35676; Evidence=; Reaction=H(+) + L-serine + octadecanoyl-CoA = 3-oxoeicosasphinganine + CO2 + CoA; Xref=Rhea:RHEA:33683, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:65073; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33684; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; SPT complex catalytic activity is negatively regulated by ORMDL proteins, including ORMDL3, in the presence of ceramides (By similarity). This mechanism allows to maintain ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (Probable). Lipid metabolism; sphingolipid metabolism. Component of the serine palmitoyltransferase (SPT) complex, which is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. The heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core of the enzyme, while SPTSSA or SPTSSB subunits determine substrate specificity. SPT also interacts with ORMDL proteins, especially ORMDL3, which negatively regulate SPT activity in the presence of ceramides. Endoplasmic reticulum membrane ; Single-pass membrane protein Expressed in white and brown adipose tissues. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Sequence=AAH94496.1; Type=Frameshift; Evidence=; catalytic activity serine C-palmitoyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process sphingolipid metabolic process biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups serine C-palmitoyltransferase complex pyridoxal phosphate binding sphingoid biosynthetic process uc008mpe.1 uc008mpe.2 
ENSMUST00000047373.6 Sox15 ENSMUST00000047373.6 SRY (sex determining region Y)-box 15 (from RefSeq NM_009235.2) ENSMUST00000047373.1 ENSMUST00000047373.2 ENSMUST00000047373.3 ENSMUST00000047373.4 ENSMUST00000047373.5 NM_009235 Q5F2B2 Q5F2B2_MOUSE Sox15 uc007jqu.1 uc007jqu.2 uc007jqu.3 uc007jqu.4 DNA binding nucleus uc007jqu.1 uc007jqu.2 uc007jqu.3 uc007jqu.4 
ENSMUST00000047383.10 Kcne2 ENSMUST00000047383.10 potassium voltage-gated channel, Isk-related subfamily, gene 2, transcript variant 1 (from RefSeq NM_134110.3) A0A0R4J1J2 A0A0R4J1J2_MOUSE ENSMUST00000047383.1 ENSMUST00000047383.2 ENSMUST00000047383.3 ENSMUST00000047383.4 ENSMUST00000047383.5 ENSMUST00000047383.6 ENSMUST00000047383.7 ENSMUST00000047383.8 ENSMUST00000047383.9 Kcne2 NM_134110 uc007zyw.1 uc007zyw.2 uc007zyw.3 uc007zyw.4 Apical cell membrane ; Single-pass membrane protein Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass membrane protein Membrane ; Single-pass type I membrane protein Belongs to the potassium channel KCNE family. inward rectifier potassium channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity endoplasmic reticulum Golgi apparatus plasma membrane ion transport potassium ion transport aging voltage-gated potassium channel complex cell surface potassium channel regulator activity membrane integral component of membrane cellular response to drug protein homodimerization activity tongue development ion channel binding regulation of membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization potassium ion transmembrane transport cardiac muscle cell action potential involved in contraction ventricular cardiac muscle cell action potential membrane repolarization membrane repolarization during action potential regulation of heart rate by cardiac conduction potassium ion export across plasma membrane membrane repolarization during ventricular cardiac muscle cell action potential regulation of potassium ion transmembrane transport positive regulation of voltage-gated calcium channel activity positive regulation of proteasomal protein catabolic process regulation of inward rectifier potassium channel activity regulation of cyclic nucleotide-gated ion channel activity regulation of delayed rectifier potassium channel activity negative regulation of delayed rectifier potassium channel activity voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization negative regulation of voltage-gated potassium channel activity potassium ion import across plasma membrane uc007zyw.1 uc007zyw.2 uc007zyw.3 uc007zyw.4 
ENSMUST00000047393.7 Ctf1 ENSMUST00000047393.7 cardiotrophin 1, transcript variant 1 (from RefSeq NM_007795.3) CTF1_MOUSE ENSMUST00000047393.1 ENSMUST00000047393.2 ENSMUST00000047393.3 ENSMUST00000047393.4 ENSMUST00000047393.5 ENSMUST00000047393.6 NM_007795 Q60753 uc009jwm.1 uc009jwm.2 uc009jwm.3 uc009jwm.4 uc009jwm.5 Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. Secreted. Highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels in testis and brain. No expression in spleen. Belongs to the IL-6 superfamily. cytokine activity leukemia inhibitory factor receptor binding extracellular region extracellular space cell surface receptor signaling pathway nervous system development positive regulation of tyrosine phosphorylation of STAT protein neuron development leukemia inhibitory factor signaling pathway uc009jwm.1 uc009jwm.2 uc009jwm.3 uc009jwm.4 uc009jwm.5 
ENSMUST00000047399.6 Adgrf1 ENSMUST00000047399.6 adhesion G protein-coupled receptor F1 (from RefSeq NM_133776.2) AGRF1_MOUSE B0V2Q5 ENSMUST00000047399.1 ENSMUST00000047399.2 ENSMUST00000047399.3 ENSMUST00000047399.4 ENSMUST00000047399.5 Gpr110 NM_133776 Q8BMV8 Q8VEC3 uc008coz.1 uc008coz.2 uc008coz.3 uc008coz.4 Orphan receptor. Cell membrane ; Multi-pass membrane protein Expressed in liver, kidney and adrenal gland. In kidney strong expression in the renal pelvis and the ureter. Glycosylated. Mice lacking Adgrf1 show no visible phenotype. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Sequence=BAC25606.1; Type=Frameshift; Evidence=; transmembrane signaling receptor activity G-protein coupled receptor activity protein binding plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway synapse assembly memory membrane integral component of membrane neuron projection development positive regulation of CREB transcription factor activity uc008coz.1 uc008coz.2 uc008coz.3 uc008coz.4 
ENSMUST00000047404.7 Dync1li1 ENSMUST00000047404.7 dynein cytoplasmic 1 light intermediate chain 1 (from RefSeq NM_146229.2) DC1L1_MOUSE Dncli1 Dnclic1 ENSMUST00000047404.1 ENSMUST00000047404.2 ENSMUST00000047404.3 ENSMUST00000047404.4 ENSMUST00000047404.5 ENSMUST00000047404.6 NM_146229 Q8R1Q8 uc009rxy.1 uc009rxy.2 uc009rxy.3 uc009rxy.4 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores (By similarity). Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (By similarity). Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non- catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with PCNT (By similarity). Forms a complex with RAB11FIP3 and RAB11A1; the interaction between DYNC1LI1 and RAB11FIP3 is direct and induces DYNC1LI1 localization onto endosomal membrane; the complex regulates endocytic trafficking (By similarity). Cytoplasm Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle pole Recycling endosome membrane Phosphorylated during mitosis but not in interphase. Belongs to the dynein light intermediate chain family. nucleotide binding microtubule cytoskeleton organization chromosome, centromeric region kinetochore condensed chromosome kinetochore spindle pole motor activity microtubule motor activity ATP binding chromosome cytoplasm centrosome cytoskeleton cytoplasmic dynein complex microtubule microtubule-based movement cell cycle GDP binding dynein complex dynein heavy chain binding regulation of centrosome cycle protein homooligomerization cell division positive regulation of mitotic cell cycle spindle assembly checkpoint cellular response to nerve growth factor stimulus lysosome late endosome uc009rxy.1 uc009rxy.2 uc009rxy.3 uc009rxy.4 
ENSMUST00000047405.9 Nckap1l ENSMUST00000047405.9 NCK associated protein 1 like (from RefSeq NM_153505.4) ENSMUST00000047405.1 ENSMUST00000047405.2 ENSMUST00000047405.3 ENSMUST00000047405.4 ENSMUST00000047405.5 ENSMUST00000047405.6 ENSMUST00000047405.7 ENSMUST00000047405.8 Hem1 NCKPL_MOUSE NM_153505 Nckap1l Q8K1X4 uc007xyf.1 uc007xyf.2 uc007xyf.3 Essential hematopoietic-specific regulator of the actin cytoskeleton. Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:19015308, PubMed:23424621). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization (PubMed:23424621). Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (PubMed:19015308). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells. Required for efficient T-lymphocyte and neutrophil migration (By similarity). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin. Also involved in mechanisms WAVE independent to regulate myosin and actin polymerization during neutrophil chemotaxis (By similarity). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (By similarity). In hematopoietic cells, component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1L/HEM1 and WASF2/WAVE2. Interacts with ARHGAP4, PIK3C3/VPS34 and PPP1R12A/MYPT1. Interacts with mammalian target of rapamycin complex 2 (mTORC2) components, including MTOR and RICTOR. Membrane ; Single- pass membrane protein Cytoplasm Note=Localizes to the leading edge of polarized neutrophils. Predominantly expressed in developing and mature hematopoietic cells. Also detected in urogenital tissues, including testis. Mutants exhibit lymphopenia, neutrophilia and anemia. T cell development is disrupted at the CD4(-)CD8(-) to CD4(+)CD8(+) cell stages and T cell activation and adhesion are impaired. Neutrophils fail to migrate in response to chemotactic agents and are deficient in their ability to phagocytose bacteria. They show enhanced Th17 cells production (PubMed:19015308). The anemia is microcytic, hypochromic and characterized by abnormally shaped erythrocytes with aberrant F-actin foci and decreased lifespan (PubMed:23424621). cell morphogenesis B cell homeostasis myeloid cell homeostasis GTPase activator activity cytoplasm cytosol chemotaxis membrane integral component of membrane cell migration maintenance of cell polarity cell projection assembly protein kinase activator activity neutrophil chemotaxis positive regulation of actin filament polymerization cortical actin cytoskeleton organization positive regulation of B cell proliferation SCAR complex activation of protein kinase activity negative regulation of interleukin-17 production negative regulation of interleukin-6 production positive regulation of cell adhesion mediated by integrin erythrocyte homeostasis negative regulation of myosin-light-chain-phosphatase activity positive regulation of T cell proliferation positive regulation of phosphorylation response to drug T cell homeostasis negative regulation of apoptotic process positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of CD8-positive, alpha-beta T cell differentiation positive regulation of GTPase activity macromolecular complex binding positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of lymphocyte differentiation positive regulation of erythrocyte differentiation neuron projection morphogenesis erythrocyte development B cell receptor signaling pathway positive regulation of phagocytosis, engulfment macromolecular complex assembly actin polymerization-dependent cell motility positive regulation of neutrophil chemotaxis Rac GTPase binding uc007xyf.1 uc007xyf.2 uc007xyf.3 
ENSMUST00000047408.6 Atcay ENSMUST00000047408.6 ataxia, cerebellar, Cayman type (from RefSeq NM_178662.4) ATCAY_MOUSE ENSMUST00000047408.1 ENSMUST00000047408.2 ENSMUST00000047408.3 ENSMUST00000047408.4 ENSMUST00000047408.5 NM_178662 Q3TR94 Q8BHE3 uc007ggo.1 uc007ggo.2 uc007ggo.3 Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites. Interacts with KLC1; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections. Interacts with GLS; the interaction is direct and may control GLS localization, negatively regulating its activity. Interacts with PIN1 (via WW domain); upon NGF stimulation (By similarity). The interaction with PIN1 and GLS is competitive (By similarity). Cell projection, axon Cell projection, dendrite Presynapse Mitochondrion Cell projection, growth cone Cytoplasm Neuronal tissues specific. Strongly expressed in brain. Expressed in virtually all parts of the adult brain, including cortex, cerebellum and olfactory bulbs. Enriched in hippocampus, cerebellar cortex, deep cerebellar nuclei, and pontine nuclei (at protein level). Expressed in embryo, where it is also completely restricted to neuronal tissues, including brain, dorsal root ganglia and enteric nervous system. MRNA and protein expressions are not correlated during development. The CRAL-TRIO domain is known to bind small hydrophobic molecules. Cleaved by CASP3 and CASP7. The potential C-terminal product released by CASP3 cleavage may inhibit the ERK signaling pathway through MAP2K2. May be ubiquitinated by STUB1. Note=Defects in Atcay are the cause of jittery phenotype, which is characterized by severe truncal and limb ataxia and death due to starvation and dehydration by 3-4 weeks of age. exopolyphosphatase activity cytoplasm mitochondrion mitochondrial envelope polyphosphate catabolic process apoptotic process nervous system development kinesin binding cell junction axon dendrite neuron projection development mitochondrial membrane regulation of protein localization cell projection neuron projection neuron projection terminus synapse mitochondrion distribution perinuclear region of cytoplasm negative regulation of glutamate metabolic process uc007ggo.1 uc007ggo.2 uc007ggo.3 
ENSMUST00000047419.8 Tspo ENSMUST00000047419.8 translocator protein (from RefSeq NM_009775.4) Bzrp ENSMUST00000047419.1 ENSMUST00000047419.2 ENSMUST00000047419.3 ENSMUST00000047419.4 ENSMUST00000047419.5 ENSMUST00000047419.6 ENSMUST00000047419.7 Mbr NM_009775 P50637 Q541E3 Q62118 Q6LCZ0 Q99M32 TSPO_MOUSE uc007xbg.1 uc007xbg.2 uc007xbg.3 uc007xbg.4 Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:9832438, PubMed:24814875), but its precise physiological role is controversial. According to some reports, it is not required for steroid hormone biosynthesis (PubMed:24174323, PubMed:24936060). Interacts with TSPOAP1. Interacts with MOST-1. May interact with STAR. Mitochondrion membrane ; Multi-pass membrane protein Membrane; Multi-pass membrane protein. Detected in liver (at protein level). Ubiquitous. By dimethyl sulfoxide and diazepam. No obvious phenotype. Mice are viable and fertile and present only very minor changes in gonadal and adrenal steroid hormone production. testis-specific gene disruption (PubMed:24174323) does not affect testosterone production, gametogenesis and male fertility. Belongs to the TspO/BZRP family. androgen binding mitochondrion mitochondrial outer membrane endoplasmic reticulum steroid biosynthetic process ion transport chloride transport lipid transport aging glial cell migration benzodiazepine receptor activity response to manganese ion response to vitamin B1 negative regulation of mitochondrion organization positive regulation of necrotic cell death peripheral nervous system axon regeneration cholesterol binding membrane integral component of membrane adrenal gland development negative regulation of protein ubiquitination mitochondrial membrane response to progesterone negative regulation of tumor necrosis factor production response to testosterone response to drug positive regulation of apoptotic process ion channel binding negative regulation of nitric oxide biosynthetic process response to pain behavioral response to pain response to axon injury regulation of steroid biosynthetic process positive regulation of mitochondrial depolarization positive regulation of calcium ion transport contact inhibition positive regulation of glial cell proliferation negative regulation of glial cell proliferation cellular response to lipopolysaccharide cellular response to zinc ion cellular hypotonic response establishment of protein localization to mitochondrion maintenance of protein location in mitochondrion negative regulation of mitophagy negative regulation of ATP metabolic process positive regulation of reactive oxygen species metabolic process uc007xbg.1 uc007xbg.2 uc007xbg.3 uc007xbg.4 
ENSMUST00000047421.6 Tie1 ENSMUST00000047421.6 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (from RefSeq NM_011587.2) ENSMUST00000047421.1 ENSMUST00000047421.2 ENSMUST00000047421.3 ENSMUST00000047421.4 ENSMUST00000047421.5 NM_011587 Q06806 Q811F4 Q8BGI2 TIE1_MOUSE Tie Tie-1 uc008ukh.1 uc008ukh.2 uc008ukh.3 Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Heterodimer with TEK/TIE2 (By similarity). Interacts with SVEP1 (via C-terminus) (By similarity). Cell membrane ; Single-pass type I membrane protein Specifically expressed in developing vascular endothelial cells. Abundantly expressed in lung and heart, moderately in brain, liver and kidney, and weakly in thymus, spleen and testis. Expressed in dermal lymphatic endothelial cells at 16.5 and 18.5 dpc (at protein level) (PubMed:28179430). Expressed in the endocardium, dorsal aorta and maternal decidual blood vessel at 8.5 dpc (PubMed:8415706). Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2. Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. nucleotide binding angiogenesis blood vessel development vasculogenesis in utero embryonic development protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway membrane integral component of membrane kinase activity phosphorylation negative regulation of angiogenesis transferase activity peptidyl-tyrosine phosphorylation negative regulation of cell migration response to retinoic acid receptor complex plasma membrane fusion positive regulation of angiogenesis uc008ukh.1 uc008ukh.2 uc008ukh.3 
ENSMUST00000047429.9 Mrps6 ENSMUST00000047429.9 mitochondrial ribosomal protein S6 (from RefSeq NM_080456.1) ENSMUST00000047429.1 ENSMUST00000047429.2 ENSMUST00000047429.3 ENSMUST00000047429.4 ENSMUST00000047429.5 ENSMUST00000047429.6 ENSMUST00000047429.7 ENSMUST00000047429.8 Mrps6 NM_080456 Q3TLQ4 Q3TLQ4_MOUSE uc007zyu.1 uc007zyu.2 uc007zyu.3 Belongs to the bacterial ribosomal protein bS6 family. structural constituent of ribosome mitochondrial small ribosomal subunit ribosome translation rRNA binding uc007zyu.1 uc007zyu.2 uc007zyu.3 
ENSMUST00000047431.11 AU040320 ENSMUST00000047431.11 expressed sequence AU040320, transcript variant 3 (from RefSeq NM_133886.2) A2A790 Aavr ENSMUST00000047431.1 ENSMUST00000047431.10 ENSMUST00000047431.2 ENSMUST00000047431.3 ENSMUST00000047431.4 ENSMUST00000047431.5 ENSMUST00000047431.6 ENSMUST00000047431.7 ENSMUST00000047431.8 ENSMUST00000047431.9 K319L_MOUSE Kiaa0319l NM_133886 Q3TTA3 Q8BHR5 Q8BHU7 Q8BHZ3 Q8K135 Q8VBZ9 uc008utw.1 uc008utw.2 Possible role in axon guidance through interaction with RTN4R. (Microbial infection) Acts as a receptor for adeno-associated virus and is involved in adeno-associated virus infection through endocytosis system. Interacts with RTN4R. Cytoplasmic granule membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Traffics from the plasma membrane to the trans-Golgi network. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K135-1; Sequence=Displayed; Name=2; IsoId=Q8K135-2; Sequence=VSP_032956; N-glycosylated. Homozygous knockout mice Kiaa0319l are normal. Sequence=AAH22154.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; Golgi membrane acrosome assembly neuron migration molecular_function Golgi apparatus trans-Golgi network plasma membrane spermatogenesis response to auditory stimulus membrane integral component of membrane receptor-mediated endocytosis of virus by host cell flagellated sperm motility cytoplasmic vesicle uc008utw.1 uc008utw.2 
ENSMUST00000047443.5 Mansc1 ENSMUST00000047443.5 MANSC domain containing 1 (from RefSeq NM_026345.4) ENSMUST00000047443.1 ENSMUST00000047443.2 ENSMUST00000047443.3 ENSMUST00000047443.4 MANS1_MOUSE NM_026345 Q80V71 Q9CR33 uc009ekm.1 uc009ekm.2 uc009ekm.3 Membrane ; Single-pass type I membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009ekm.1 uc009ekm.2 uc009ekm.3 
ENSMUST00000047477.4 Sprr2d ENSMUST00000047477.4 small proline-rich protein 2D (from RefSeq NM_011470.3) ENSMUST00000047477.1 ENSMUST00000047477.2 ENSMUST00000047477.3 NM_011470 O70555 SPR2D_MOUSE uc008qds.1 uc008qds.2 uc008qds.3 Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). Cytoplasm Expressed in uterus. During early pregnancy, uterine expression is markedly increased at 1 dpc and 2 dpc, with levels decreasing from 3 dpc onwards. Up-regulated by estrogen in the uterus of ovariectomized animals, with strongly increased expression detected in luminal epithelial cells at 6 and 12 hours after hormone injection. Belongs to the cornifin (SPRR) family. cornified envelope nucleus cytoplasm epidermis development female gonad development keratinocyte differentiation keratinization response to estradiol uc008qds.1 uc008qds.2 uc008qds.3 
ENSMUST00000047479.3 Pcdhac2 ENSMUST00000047479.3 protocadherin alpha subfamily C, 2 (from RefSeq NM_001003672.2) ENSMUST00000047479.1 ENSMUST00000047479.2 NM_001003672 Pcdhac2 Q91Y09 Q91Y09_MOUSE uc008epk.1 uc008epk.2 uc008epk.3 uc008epk.4 uc008epk.5 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules nervous system development membrane integral component of membrane metal ion binding uc008epk.1 uc008epk.2 uc008epk.3 uc008epk.4 uc008epk.5 
ENSMUST00000047486.6 Steep1 ENSMUST00000047486.6 Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity). Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (PubMed:32690950). (from UniProt Q8VDP2) A2A3V4 AK035825 ENSMUST00000047486.1 ENSMUST00000047486.2 ENSMUST00000047486.3 ENSMUST00000047486.4 ENSMUST00000047486.5 Q3URC0 Q8C8Z1 Q8VDP2 Q9CWC1 STEEP_MOUSE Steep1 uc292nsm.1 uc292nsm.2 Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity). Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (PubMed:32690950). Interacts with STING1, PIK3C3, and ATG14; the STING1/STEEP1 interaction is increased upon STING1 cGAMP-activation and leads to recruitment of PI3K complex I. Nucleus Cytoplasm Note=Detected in the nucleus and cell soma of pyramidal neurons in the brain cortex and Purkinje cells, as well as in neurons in the granular layer in the cerebellum. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VDP2-1; Sequence=Displayed; Name=2; IsoId=Q8VDP2-2; Sequence=VSP_025569; Expressed in neurons in the brain cortex and cerebellum (at protein level). Belongs to the STEEP1 family. Sequence=CAM19776.1; Type=Erroneous gene model prediction; Evidence=; molecular_function nucleus cytoplasm biological_process cell body uc292nsm.1 uc292nsm.2 
ENSMUST00000047497.15 Cep104 ENSMUST00000047497.15 centrosomal protein 104, transcript variant 1 (from RefSeq NM_177673.3) B1AX97 CE104_MOUSE ENSMUST00000047497.1 ENSMUST00000047497.10 ENSMUST00000047497.11 ENSMUST00000047497.12 ENSMUST00000047497.13 ENSMUST00000047497.14 ENSMUST00000047497.2 ENSMUST00000047497.3 ENSMUST00000047497.4 ENSMUST00000047497.5 ENSMUST00000047497.6 ENSMUST00000047497.7 ENSMUST00000047497.8 ENSMUST00000047497.9 Kiaa0562 NM_177673 Q6ZQ95 Q80V31 uc008wax.1 uc008wax.2 uc008wax.3 Required for ciliogenesis and for structural integrity at the ciliary tip. Interacts with CCP110 and CEP97. Interacts with ARMC9, TOGARAM1, CCDC66 and CSPP1. Q80V31; Q15637: SF1; Xeno; NbExp=3; IntAct=EBI-11073001, EBI-744603; Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Note=In interphase non-ciliated cells, localizes to the distal ends of both the mother and daughter centrioles. In ciliated cells, present at the distal end of the daughter centriole, but not on the mother centriole, and at the tip of primary cilium. Localization at the ciliary tip is also observed in motile cilia. Throughout S phase, associated with both mother and daughter centrioles in each centrosome. During metaphase and telophase, present at both spindle poles. spindle pole protein binding cytoplasm centriole microtubule organizing center cytoskeleton cilium biological_process glycine binding glutamate binding thienylcyclohexylpiperidine binding cell projection uc008wax.1 uc008wax.2 uc008wax.3 
ENSMUST00000047498.15 AA467197 ENSMUST00000047498.15 expressed sequence AA467197 (from RefSeq NM_001004174.2) ENSMUST00000047498.1 ENSMUST00000047498.10 ENSMUST00000047498.11 ENSMUST00000047498.12 ENSMUST00000047498.13 ENSMUST00000047498.14 ENSMUST00000047498.2 ENSMUST00000047498.3 ENSMUST00000047498.4 ENSMUST00000047498.5 ENSMUST00000047498.6 ENSMUST00000047498.7 ENSMUST00000047498.8 ENSMUST00000047498.9 NMES1_MOUSE NM_001004174 Nmes1 Q810Q5 uc008may.1 uc008may.2 uc008may.3 Nucleus Strongly expressed in vertebrae, brain, intestine and stomach. First detected at 8 dpc in the ossification center and the spinal cord. From this stage up to birth, expression extends throughout the bone tissue and strong expression is detected in the vertebrae. At 16 dpc, detected in the developing brain, including the prosencephalon, mesencephalon, diencephalon, telencephalon and rhombencephalon, and in the intestine. Faint expression at 16 dpc in the lung. Belongs to the complex I NDUFA4 subunit family. nucleus mitochondrion mitochondrial respiratory chain complex IV response to bacterium electron transport chain hydrogen ion transmembrane transport cytochrome-c oxidase activity uc008may.1 uc008may.2 uc008may.3 
ENSMUST00000047503.16 Rgl2 ENSMUST00000047503.16 ral guanine nucleotide dissociation stimulator-like 2, transcript variant 9 (from RefSeq NR_177105.1) ENSMUST00000047503.1 ENSMUST00000047503.10 ENSMUST00000047503.11 ENSMUST00000047503.12 ENSMUST00000047503.13 ENSMUST00000047503.14 ENSMUST00000047503.15 ENSMUST00000047503.2 ENSMUST00000047503.3 ENSMUST00000047503.4 ENSMUST00000047503.5 ENSMUST00000047503.6 ENSMUST00000047503.7 ENSMUST00000047503.8 ENSMUST00000047503.9 NR_177105 Q61193 Q9QUJ2 RGL2_MOUSE Rab2l Rlf uc008cag.1 uc008cag.2 uc008cag.3 Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro. Interacts with SAMD9. guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity signal transduction small GTPase mediated signal transduction negative regulation of cardiac muscle cell apoptotic process positive regulation of phosphatidylinositol 3-kinase signaling regulation of Ral protein signal transduction uc008cag.1 uc008cag.2 uc008cag.3 
ENSMUST00000047511.15 Shtn1 ENSMUST00000047511.15 shootin 1, transcript variant 1 (from RefSeq NM_001114312.1) ENSMUST00000047511.1 ENSMUST00000047511.10 ENSMUST00000047511.11 ENSMUST00000047511.12 ENSMUST00000047511.13 ENSMUST00000047511.14 ENSMUST00000047511.2 ENSMUST00000047511.3 ENSMUST00000047511.4 ENSMUST00000047511.5 ENSMUST00000047511.6 ENSMUST00000047511.7 ENSMUST00000047511.8 ENSMUST00000047511.9 Kiaa1598 NM_001114312 Q5DTW5 Q8C4F6 Q8K2Q9 SHOT1_MOUSE Shtn1 uc008ibe.1 uc008ibe.2 uc008ibe.3 Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth (PubMed:23864681). Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth (By similarity). In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex (PubMed:23864681). Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons (PubMed:23864681). Interacts with L1CAM; this interaction occurs at axonal growth cones. Interacts with actin filament retrograde flow; this interaction is enhanced in a netrin-1- and PAK1-dependent manner and promotes F- actin-substrate coupling and concomitant formation of traction forces at axonal growth cones. Interacts with RUFY3 (By similarity). Interacts with PFN2 (PubMed:19403918). Interacts (via N-terminus) with KIF20B; this interaction is direct and promotes the association of SHTN1 to microtubules in primary neurons (PubMed:23864681). Associates with microtubule (PubMed:23864681). Perikaryon Cell projection, axon Cell projection, growth cone Cytoplasm, cytoskeleton Cell projection, filopodium Cell projection, lamellipodium Note=Localizes in multiple growth cones at neurite tips before the neuronal symmetry- breaking step. Accumulates in growth cones of a single nascent axon in a neurite length-dependent manner during the neuronal symmetry-breaking step; when absent from the nascent axon's siblings, probably due to competitive transport, prevents the formation of surplus axons. Transported anterogradely from the soma to the axon growth cone in an actin and myosin-dependent manner and passively diffuses back to the cell bodies. Colocalized with L1CAM in close apposition with actin filaments in filopodia and lamellipodia of axonal growth cones in hippocampal neurons. Exhibits retrograde movements in filopodia and lamellopodia of axonal growth cones (By similarity). Colocalized with KIF20B along microtubules to the tip of the growing cone in primary hippocampal neurons (PubMed:23864681). Recruited to the growth cone of developing axon in a KIF20B- and microtubule-dependent manner (PubMed:23864681). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2Q9-1; Sequence=Displayed; Name=2; IsoId=Q8K2Q9-2; Sequence=VSP_027054, VSP_027055; Expressed in hippocampal neurons (PubMed:17030985). Expressed in the developing brain. Expressed in the developing cortical plate at 11 and 14 dpc. Expressed in multipolar cells at 14 dpc (at protein level). Expressed in the developing cortical plate of the telencephalon (PubMed:23864681). The N-terminus region is necessary for interaction with actin retrograde filament flow and accumulation in neuronal growth cones. Phosphorylated on Ser-101 and Ser-249 by PAK1 through a CDC42- and RAC1-dependent signaling pathway, which enhances its association with F-actin retrograde flow in filopodia and lamellipodia of axonal growth cones. Phosphorylation on Ser-101 and Ser-249 is increased by netrin-1. Belongs to the shootin family. Sequence=BAD90258.1; Type=Erroneous initiation; Evidence=; protein binding cytoplasm cytoskeleton microtubule microtubule associated complex substrate-dependent cell migration, cell extension Ras protein signal transduction multicellular organism development axonogenesis microtubule cytoskeleton kinesin binding lamellipodium filopodium axon growth cone cell leading edge Cdc42 protein signal transduction netrin-activated signaling pathway cell projection perikaryon axonal growth cone positive regulation of axon extension perinuclear region of cytoplasm neuron projection morphogenesis cell adhesion molecule binding actin filament binding membrane depolarization cytoplasmic actin-based contraction involved in cell motility endoplasmic reticulum polarization actin filament bundle retrograde transport regulation of establishment of cell polarity regulation of neuron migration positive regulation of neuron migration uc008ibe.1 uc008ibe.2 uc008ibe.3 
ENSMUST00000047521.7 Cercam ENSMUST00000047521.7 cerebral endothelial cell adhesion molecule (from RefSeq NM_207298.2) B2RSF7 B2RSF7_MOUSE Cercam ENSMUST00000047521.1 ENSMUST00000047521.2 ENSMUST00000047521.3 ENSMUST00000047521.4 ENSMUST00000047521.5 ENSMUST00000047521.6 NM_207298 uc008jai.1 uc008jai.2 Belongs to the glycosyltransferase 25 family. cell adhesion uc008jai.1 uc008jai.2 
ENSMUST00000047524.10 Thada ENSMUST00000047524.10 thyroid adenoma associated, transcript variant 1 (from RefSeq NM_183021.3) A8C756 ENSMUST00000047524.1 ENSMUST00000047524.2 ENSMUST00000047524.3 ENSMUST00000047524.4 ENSMUST00000047524.5 ENSMUST00000047524.6 ENSMUST00000047524.7 ENSMUST00000047524.8 ENSMUST00000047524.9 Kiaa1767 NM_183021 Q3TDR4 Q3U2L1 Q69ZA8 Q7TPV7 Q8C8S7 THADA_MOUSE uc012axy.1 uc012axy.2 uc012axy.3 Together with methyltransferase FTSJ1, methylates the 2'-O- ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A8C756-1; Sequence=Displayed; Name=2; IsoId=A8C756-2; Sequence=VSP_034737; Name=3; IsoId=A8C756-3; Sequence=VSP_034736; Name=4; IsoId=A8C756-4; Sequence=VSP_034738, VSP_034739; Name=5; IsoId=A8C756-5; Sequence=VSP_034740; Belongs to the THADA family. Sequence=BAD32536.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAE33129.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAE41536.1; Type=Frameshift; Evidence=; molecular_function cytosol tRNA methylation negative regulation of endoplasmic reticulum calcium ion concentration lipid homeostasis uc012axy.1 uc012axy.2 uc012axy.3 
ENSMUST00000047526.8 Asap3 ENSMUST00000047526.8 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3, transcript variant 2 (from RefSeq NM_001355698.1) ASAP3_MOUSE Ddefl1 ENSMUST00000047526.1 ENSMUST00000047526.2 ENSMUST00000047526.3 ENSMUST00000047526.4 ENSMUST00000047526.5 ENSMUST00000047526.6 ENSMUST00000047526.7 NM_001355698 Q5U464 uc008vhu.1 uc008vhu.2 uc008vhu.3 uc008vhu.4 Promotes cell proliferation. Cytoplasm ruffle GTPase activator activity nucleoplasm cytoplasm cytosol focal adhesion cell migration intracellular membrane-bounded organelle positive regulation of GTPase activity metal ion binding regulation of stress fiber assembly uc008vhu.1 uc008vhu.2 uc008vhu.3 uc008vhu.4 
ENSMUST00000047527.8 Zfp804a ENSMUST00000047527.8 zinc finger protein 804A (from RefSeq NM_175513.3) A2AKY4 ENSMUST00000047527.1 ENSMUST00000047527.2 ENSMUST00000047527.3 ENSMUST00000047527.4 ENSMUST00000047527.5 ENSMUST00000047527.6 ENSMUST00000047527.7 NM_175513 Q8BHY7 Z804A_MOUSE Znf804a uc008khu.1 uc008khu.2 uc008khu.3 uc008khu.4 nucleic acid binding nucleus cytoplasm plasma membrane positive regulation of gene expression regulation of neuron projection development positive regulation of neuron projection development axon growth cone neuronal cell body dendritic spine dendritic shaft metal ion binding presynapse postsynapse dendritic microtubule positive regulation of dendritic spine maintenance uc008khu.1 uc008khu.2 uc008khu.3 uc008khu.4 
ENSMUST00000047531.16 Etfbkmt ENSMUST00000047531.16 electron transfer flavoprotein beta subunit lysine methyltransferase, transcript variant 4 (from RefSeq NM_177101.5) B8JKU7 ENSMUST00000047531.1 ENSMUST00000047531.10 ENSMUST00000047531.11 ENSMUST00000047531.12 ENSMUST00000047531.13 ENSMUST00000047531.14 ENSMUST00000047531.15 ENSMUST00000047531.2 ENSMUST00000047531.3 ENSMUST00000047531.4 ENSMUST00000047531.5 ENSMUST00000047531.6 ENSMUST00000047531.7 ENSMUST00000047531.8 ENSMUST00000047531.9 ETKMT_MOUSE Mettl20 NM_177101 Q3V219 Q80ZM3 Q8VEL3 uc009etx.1 uc009etx.2 uc009etx.3 uc009etx.4 Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases. Interacts with HSPD1; this protein may possibly be a methylation substrate. Cytoplasm Mitochondrion matrix Note=Concentrated in cytoplasmic granular foci. Belongs to the methyltransferase superfamily. ETFBKMT family. cytoplasm mitochondrion mitochondrial matrix methyltransferase activity protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine methylation peptidyl-lysine trimethylation heat shock protein binding methylation macromolecular complex negative regulation of electron carrier activity negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase uc009etx.1 uc009etx.2 uc009etx.3 uc009etx.4 
ENSMUST00000047534.12 Fam168b ENSMUST00000047534.12 family with sequence similarity 168, member B, transcript variant 3 (from RefSeq NM_174997.3) ENSMUST00000047534.1 ENSMUST00000047534.10 ENSMUST00000047534.11 ENSMUST00000047534.2 ENSMUST00000047534.3 ENSMUST00000047534.4 ENSMUST00000047534.5 ENSMUST00000047534.6 ENSMUST00000047534.7 ENSMUST00000047534.8 ENSMUST00000047534.9 F168B_MOUSE Kiaa4042 NM_174997 Q3UNC7 Q5DTR7 Q80XQ8 uc007apj.1 uc007apj.2 uc007apj.3 uc007apj.4 Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. May form homodimers (By similarity). May interact with DAZAP2, FAM168A, PRDX6, RBM6, TMTC1 and YPEL2 (By similarity). Interacts with CDC27 (PubMed:20716133). Cytoplasm, perinuclear region Cell membrane ; Multi-pass membrane protein Cell projection, axon Note=Expressed in neuronal cell bodies and axonal fibers. Predominantly expressed in the brain, including olfactory bulb, cortex and cerebellum (at protein level). Specifically expressed in differentiated neurons, but absent from proliferating neural stem cells. Up-regulated by different neurotrophins, including NGF and BDNF, but not by growth factors, such as EGF. N-glycosylated. Belongs to the FAM168 family. Sequence=BAD90278.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cytoplasm plasma membrane biological_process membrane integral component of membrane axon cell projection perinuclear region of cytoplasm uc007apj.1 uc007apj.2 uc007apj.3 uc007apj.4 
ENSMUST00000047558.14 Prc1 ENSMUST00000047558.14 protein regulator of cytokinesis 1, transcript variant 2 (from RefSeq NM_001285997.2) E9QPF0 ENSMUST00000047558.1 ENSMUST00000047558.10 ENSMUST00000047558.11 ENSMUST00000047558.12 ENSMUST00000047558.13 ENSMUST00000047558.2 ENSMUST00000047558.3 ENSMUST00000047558.4 ENSMUST00000047558.5 ENSMUST00000047558.6 ENSMUST00000047558.7 ENSMUST00000047558.8 ENSMUST00000047558.9 NM_001285997 PRC1_MOUSE Prc1 Q8CE25 Q99K43 uc012fno.1 uc012fno.2 uc012fno.3 Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. Homodimer. Interacts with the C-terminal Rho-GAP domain and the basic region of RACGAP1. The interaction with RACGAP1 inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology. Interacts (via N-terminus) with the C-terminus of CENPE (via C-terminus); the interaction occurs during late mitosis. Interacts (via N-terminus) with KIF4A (via C-terminus); the interaction is required for the progression of mitosis. Interacts (via N-terminus) with KIF23 (via C-terminus); the interaction occurs during late mitosis. Interacts with KIF14 and KIF20A. Interacts with PLK1. Interacts with KIF20B. Nucleus Cytoplasm Cytoplasm, cytoskeleton, spindle pole Midbody Note=Colocalized with KIF20B in the nucleus of bladder carcinoma cells at the interphase. Colocalized with KIF20B in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase. Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles, and localizes with the cell midbody during cytokinesis. Co- localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase. During the stages 11.5-13.5 dpc it is expressed in most embryonic tissues. Within the telencephalon, it is predominantly expressed inside the ventricular zone where expression reaches its peak at 15.5 dpc and starts to decrease by 18.5 dpc. Expression is also observed in mitotically active cells outside the telencephalon, but not in adult brain. Microtubule binding occurs via a basic patch in the central spectrin-like domain and requires also the unstructured C-terminal domain. Phosphorylation by CDK1 in early mitosis holds PRC1 in an inactive monomeric state, during the metaphase to anaphase transition, PRC1 is dephosphorylated, promoting interaction with KIF4A, which then translocates PRC1 along mitotic spindles to the plus ends of antiparallel interdigitating microtubules. Dephosphorylation also promotes MT-bundling activity by allowing dimerization. Phosphorylation by CDK1 prevents PLK1-binding: upon degradation of CDK1 at anaphase and dephosphorylation, it is then phosphorylated by PLK1, leading to cytokinesis (By similarity). Belongs to the MAP65/ASE1 family. Sequence=BAC26320.1; Type=Miscellaneous discrepancy; Note=Probable intron retention.; Evidence=; microtubule cytoskeleton organization spindle pole microtubule bundle formation nucleus cytoplasm spindle cytoskeleton microtubule cell cycle microtubule binding positive regulation of cell proliferation kinesin binding protein kinase binding midbody regulation of cytokinesis identical protein binding cell division contractile ring uc012fno.1 uc012fno.2 uc012fno.3 
ENSMUST00000047560.8 Dhrs11 ENSMUST00000047560.8 dehydrogenase/reductase 11 (from RefSeq NM_177564.5) DHR11_MOUSE ENSMUST00000047560.1 ENSMUST00000047560.2 ENSMUST00000047560.3 ENSMUST00000047560.4 ENSMUST00000047560.5 ENSMUST00000047560.6 ENSMUST00000047560.7 NM_177564 Q3U0B3 Q5SXB3 Q8R249 Sdr24c1 uc007kqs.1 uc007kqs.2 uc007kqs.3 uc007kqs.4 Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. Reaction=a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH; Xref=Rhea:RHEA:34787, ChEBI:CHEBI:15378, ChEBI:CHEBI:36836, ChEBI:CHEBI:47788, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.270; Evidence=; Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence=; Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH; Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62; Evidence=; Inhibited by flavonoids including apigenin, luteolin, genistein, kaempferol and quercetin and also by carbenoxolone, zearalenone, glycyrrhetinic, curcumin and flufenamic acid. Steroid biosynthesis; estrogen biosynthesis. Homotetramer. Secreted Belongs to the short-chain dehydrogenases/reductases (SDR) family. It is uncertain whether Met-1 or Met-6 is the initiator. nucleotide binding 3-keto sterol reductase activity estradiol 17-beta-dehydrogenase activity cellular_component extracellular region lipid metabolic process steroid biosynthetic process estrogen biosynthetic process steroid metabolic process oxidoreductase activity oxidation-reduction process 17-beta-ketosteroid reductase activity 17-beta-hydroxysteroid dehydrogenase (NADP+) activity uc007kqs.1 uc007kqs.2 uc007kqs.3 uc007kqs.4 
ENSMUST00000047568.5 Havcr1 ENSMUST00000047568.5 hepatitis A virus cellular receptor 1, transcript variant 1 (from RefSeq NM_134248.2) A0A0A0MQ86 A0A0A0MQ86_MOUSE ENSMUST00000047568.1 ENSMUST00000047568.2 ENSMUST00000047568.3 ENSMUST00000047568.4 Havcr1 NM_134248 uc007iow.1 uc007iow.2 uc007iow.3 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the immunoglobulin superfamily. TIM family. membrane integral component of membrane uc007iow.1 uc007iow.2 uc007iow.3 
ENSMUST00000047577.7 Prdm14 ENSMUST00000047577.7 PR domain containing 14 (from RefSeq NM_001081209.3) E9Q3T6 ENSMUST00000047577.1 ENSMUST00000047577.2 ENSMUST00000047577.3 ENSMUST00000047577.4 ENSMUST00000047577.5 ENSMUST00000047577.6 NM_001081209 PRD14_MOUSE Q3URU1 uc007aik.1 uc007aik.2 uc007aik.3 Transcription factor that has both positive and negative roles on transcription (By similarity). Plays a role in cellular pluripotency. Essential for germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation. Interacts with CBFA2T2. Nucleus Restricted to embryonic stem cells and primordial germ cells. Not detected in epiblast-derived stem cells. At 3.5 dpc, weak and transient expression in the inner cell mass cells of blastocysts. This expression disappears by 5.5 dpc. Expression starts again in committed PGCs around 6.5 dpc in the extraembryonic mesoderm contiguous from the most proximal epiblast (at protein level). Expression persists specifically in PGCs until about 13.5-14.5 dpc both in females and males. Mutant mice are born with an expected Mendelian ratio and looked grossly normal. However, both females and males are sterile, ovaries and testes being completely devoid of germ cells. Belongs to the class V-like SAM-binding methyltransferase superfamily. negative regulation of transcription from RNA polymerase II promoter cell morphogenesis RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding cell fate specification inner cell mass cell fate commitment nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding RNA binding protein binding nucleus nucleoplasm germ cell development embryo implantation methyltransferase activity fertilization regulation of gene expression transferase activity stem cell population maintenance germ-line stem cell population maintenance chromatin DNA binding methylation histone H3-R26 methylation regulation of gene expression, epigenetic negative regulation of fibroblast growth factor receptor signaling pathway sequence-specific DNA binding regulation of DNA methylation metal ion binding homeostasis of number of cells within a tissue inactivation of paternal X chromosome positive regulation of flagellated sperm motility positive regulation of stem cell population maintenance uc007aik.1 uc007aik.2 uc007aik.3 
ENSMUST00000047611.4 Nthl1 ENSMUST00000047611.4 nth (endonuclease III)-like 1 (E.coli), transcript variant 1 (from RefSeq NM_008743.2) E9QMW1 ENSMUST00000047611.1 ENSMUST00000047611.2 ENSMUST00000047611.3 NM_008743 NTH_MOUSE Nth1 O35980 uc008axi.1 uc008axi.2 uc008axi.3 uc008axi.4 Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA- COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695, ChEBI:CHEBI:167181; EC=4.2.99.18; Evidence= Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand. ; Interacts with YBX1 (By similarity). Interacts with ERCC5/XPG; the interaction stimulates NTHL1 activity and NTHL1 binding to its DNA substrate (By similarity). Nucleus Mitochondrion Widely expressed. Ubiquitinated by TRIM26; leading to proteasomal degradation. Belongs to the Nth/MutY family. Sequence=AK033701; Type=Frameshift; Evidence=; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity DNA binding double-stranded DNA binding catalytic activity DNA-(apurinic or apyrimidinic site) lyase activity nucleus mitochondrion DNA repair base-excision repair base-excision repair, AP site formation nucleotide-excision repair, DNA incision, 5'-to lesion cellular response to DNA damage stimulus metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds lyase activity DNA N-glycosylase activity metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding uc008axi.1 uc008axi.2 uc008axi.3 uc008axi.4 
ENSMUST00000047614.4 Pcdha12 ENSMUST00000047614.4 protocadherin alpha 12 (from RefSeq NM_138663.2) ENSMUST00000047614.1 ENSMUST00000047614.2 ENSMUST00000047614.3 NM_138663 Pcdha12 Q91Y18 Q91Y18_MOUSE uc008epi.1 uc008epi.2 uc008epi.3 uc008epi.4 uc008epi.5 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epi.1 uc008epi.2 uc008epi.3 uc008epi.4 uc008epi.5 
ENSMUST00000047615.15 Smarcal1 ENSMUST00000047615.15 SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (from RefSeq NM_018817.2) ENSMUST00000047615.1 ENSMUST00000047615.10 ENSMUST00000047615.11 ENSMUST00000047615.12 ENSMUST00000047615.13 ENSMUST00000047615.14 ENSMUST00000047615.2 ENSMUST00000047615.3 ENSMUST00000047615.4 ENSMUST00000047615.5 ENSMUST00000047615.6 ENSMUST00000047615.7 ENSMUST00000047615.8 ENSMUST00000047615.9 Harp NM_018817 Q3TEQ9 Q3U4W0 Q3V3A8 Q8BJL0 Q8BVK7 Q8BXW4 Q8K309 Q9EQK8 Q9QYC4 SMAL1_MOUSE uc007bks.1 uc007bks.2 uc007bks.3 uc007bks.4 ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks (By similarity). Interacts with RPA2; the interaction is direct and mediates the recruitment by the RPA complex of SMARCAL1 to sites of DNA damage. Nucleus Note=Recruited to damaged DNA regions. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BJL0-1; Sequence=Displayed; Name=2; IsoId=Q8BJL0-2; Sequence=VSP_012919, VSP_012920; Name=3; IsoId=Q8BJL0-3; Sequence=VSP_036218, VSP_036219; Name=4; IsoId=Q8BJL0-4; Sequence=VSP_036216, VSP_036217; Ubiquitously expressed, with high levels in brain, heart, kidney, liver and testis. DNA damage-regulated phosphorylation by kinases that may include ATM, ATR and PRKDC. [Isoform 2]: May be due to an intron retention. Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. nucleotide binding DNA strand renaturation helicase activity ATP binding nucleus nucleoplasm DNA replication factor A complex DNA metabolic process DNA repair regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus DNA-dependent ATPase activity hydrolase activity replication fork processing site of double-strand break DNA rewinding annealing helicase activity nuclear replication fork replication fork protection uc007bks.1 uc007bks.2 uc007bks.3 uc007bks.4 
ENSMUST00000047616.10 Jmjd6 ENSMUST00000047616.10 jumonji domain containing 6, transcript variant 3 (from RefSeq NR_156486.1) A2AA26 A8Y5I2 ENSMUST00000047616.1 ENSMUST00000047616.2 ENSMUST00000047616.3 ENSMUST00000047616.4 ENSMUST00000047616.5 ENSMUST00000047616.6 ENSMUST00000047616.7 ENSMUST00000047616.8 ENSMUST00000047616.9 JMJD6_MOUSE Kiaa0585 NR_156486 Ptdsr Q80TX1 Q9ERI5 uc007mmi.1 uc007mmi.2 This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein functions in differentiation of multiple tissues during development, and in anti-inflammatory cytokine signaling. It was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that this protein does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF527404.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382 [ECO:0000348] ##Evidence-Data-END## Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5- hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5- hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization (By similarity). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (PubMed:33443146, PubMed:25369936). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation. Demethylates other arginine methylated-proteins such as ESR1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis (PubMed:15345036). Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:21300889). Seems to be necessary for the regulation of macrophage cytokine responses (By similarity). Reaction=2-oxoglutarate + L-lysyl-[protein] + O2 = (5S)-5-hydroxy-L- lysyl-[protein] + CO2 + succinate; Xref=Rhea:RHEA:58360, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:15144, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:141843; Evidence=; Reaction=2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl- [protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate; Xref=Rhea:RHEA:58348, Rhea:RHEA-COMP:10532, Rhea:RHEA- COMP:11992, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29965, ChEBI:CHEBI:30031, ChEBI:CHEBI:88221; Evidence=; Reaction=2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl- [protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl- [protein] + succinate; Xref=Rhea:RHEA:58472, Rhea:RHEA-COMP:11990, Rhea:RHEA-COMP:11992, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:65280, ChEBI:CHEBI:88221; Evidence=; Reaction=2-oxoglutarate + a 5'-end methyltriphosphate-guanosine- ribonucleotide-snRNA + O2 = a 5'-end triphospho-guanosine- ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate; Xref=Rhea:RHEA:58784, Rhea:RHEA-COMP:15220, Rhea:RHEA-COMP:15221, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:138278, ChEBI:CHEBI:142789; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Homooligomerizes; requires lysyl-hydroxylase activity (By similarity). Interacts with LUC7L2, LUC7L3 and U2AF2/U2AF65 (PubMed:21300889). Interacts with CDK9 and CCNT1; the interaction is direct with CDK9 and associates the P-TEFb complex when active. Interacts (via JmjC and N-terminal domains) with BRD4 (via NET domain); the interaction is stronger in presence of ssRNA and recruits JMJD6 on distal enhancers (By similarity). Nucleus, nucleoplasm Nucleus, nucleolus Cytoplasm Note=Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ERI5-1; Sequence=Displayed; Name=2; IsoId=Q9ERI5-2; Sequence=VSP_014024, VSP_014025; Widely expressed. Expressed in brain, eye, spinal chord, thymus, lung, liver, kidney and intestine. Expressed early in development. Expressed from embryonic stem cells and throughout embryogenesis. The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus. Hydroxylates its own N-terminus; hydroxylation is required for homooligomerization. Mice display perinatal lethality, growth retardation, severe anemia and a delay in terminal differentiation of the kidney, intestine, liver and lungs during embryogenesis. Moreover, eye development can be severely disturbed, ranging from defects in retinal differentiation to complete unilateral or bilateral absence of eyes. According to PubMed:14645847, mice are defective in removing apoptotic cells, especially in the lung and brain, in which dead cells accumulate, causing abnormal development and leading to neonatal lethality. According to PubMed:14715629, mice lacking Jmjd6 display a reduced number of macrophages and apoptotic cells in fetal liver. In contrast, according to PubMed:15345036, mice show a normal engulfment of apoptotic cells. The contradictory results concerning apoptosis and macrophage function may be explained by the fact that the protein plays a key role in hematopoietic differentiation. Belongs to the JMJD6 family. Was initially thought to constitute the phosphatidylserine receptor, a receptor that mediates recognition of phosphatidylserine, a specific marker only present at the surface of apoptotic cells. Phosphatidylserine receptor probably participates in apoptotic cell phagocytosis. This protein was identified using phage display expressing mAb 217, an antibody that specifically recognizes phosphatidylserine receptor. However, its nuclear localization and the fact that mAb 217 antibody still recognizes the phosphatidylserine receptor in mice lacking Jmjd6, strongly suggest that it does not constitute the receptor for phosphatidylserine and is not involved in apoptotic cell removal. Sequence=BAC65599.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; blood vessel development kidney development sprouting angiogenesis transcription coactivator activity RNA binding single-stranded RNA binding iron ion binding protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol plasma membrane chromatin organization mRNA processing protein demethylation cell surface receptor signaling pathway multicellular organism development heart development RNA splicing oxidoreductase activity peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine cell differentiation lung development demethylase activity histone demethylase activity T cell differentiation in thymus histone demethylase activity (H3-R2 specific) histone demethylase activity (H4-R3 specific) oxidative RNA demethylation oxidative RNA demethylase activity signaling receptor activity macrophage activation identical protein binding protein homodimerization activity apoptotic cell clearance recognition of apoptotic cell positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding regulation of mRNA splicing, via spliceosome erythrocyte development dioxygenase activity protein homooligomerization oxidation-reduction process retina development in camera-type eye histone H3-R2 demethylation histone H4-R3 demethylation peptidyl-lysine 5-dioxygenase activity ribonucleoprotein complex uc007mmi.1 uc007mmi.2 
ENSMUST00000047620.3 Fam151a ENSMUST00000047620.3 family with sequence simliarity 151, member A (from RefSeq NM_146149.1) ENSMUST00000047620.1 ENSMUST00000047620.2 F151A_MOUSE NM_146149 Q8QZW3 uc008tyu.1 uc008tyu.2 uc008tyu.3 Membrane ; Single-pass membrane protein Belongs to the FAM151 family. molecular_function biological_process membrane integral component of membrane uc008tyu.1 uc008tyu.2 uc008tyu.3 
ENSMUST00000047621.14 Ppp1r13l ENSMUST00000047621.14 protein phosphatase 1, regulatory subunit 13 like, transcript variant 2 (from RefSeq NM_001419335.1) ENSMUST00000047621.1 ENSMUST00000047621.10 ENSMUST00000047621.11 ENSMUST00000047621.12 ENSMUST00000047621.13 ENSMUST00000047621.2 ENSMUST00000047621.3 ENSMUST00000047621.4 ENSMUST00000047621.5 ENSMUST00000047621.6 ENSMUST00000047621.7 ENSMUST00000047621.8 ENSMUST00000047621.9 IASPP_MOUSE NM_001419335 Nkip1 Ppp1r13l Q5I1X5 uc009flo.1 uc009flo.2 Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (By similarity). Interacts with TP63 and TP73 (By similarity). Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminal part. Interacts (via SH3 domain and ANK repeats) with p53/TP53; the interaction inhibits pro-apoptotic activity of p53/TP53 (By similarity). Q5I1X5; P16546: Sptan1; NbExp=2; IntAct=EBI-6691266, EBI-911063; Cytoplasm Nucleus Note=Predominantly cytoplasmic but also nuclear. Most abundant in skin with high levels also found in heart, testis and stomach. In 15.5 dpc embryonic heart, expressed at higher levels in atria than ventricles. The N-terminal region is required for cytoplasmic localization. The ANK repeats and the SH3 domain are required for specific interactions with p53/TP53. Note=Defects in Ppp1r13l are the cause of the waved 3 phenotype, a recessive mutation characterized by abnormalities of the heart and skin. Affected animals have open eyes at birth and hair abnormalities. They develop focal cardiac necrosis at an early age which progresses to fatal dilated cardiomyopathy. This is due to a 14- bp deletion which gives rise to a truncated protein. Belongs to the iASPP family. negative regulation of transcription from RNA polymerase II promoter cardiac right ventricle morphogenesis ventricular cardiac muscle tissue development protein binding nucleus cytoplasm cytosol transcription, DNA-templated apoptotic process transcription factor binding post-embryonic development cell junction embryonic camera-type eye development multicellular organism growth hair cycle identical protein binding intercellular bridge positive regulation of cell differentiation multicellular organismal homeostasis cardiac muscle contraction uc009flo.1 uc009flo.2 
ENSMUST00000047627.14 Gpbp1 ENSMUST00000047627.14 GC-rich promoter binding protein 1, transcript variant 2 (from RefSeq NM_028487.6) ENSMUST00000047627.1 ENSMUST00000047627.10 ENSMUST00000047627.11 ENSMUST00000047627.12 ENSMUST00000047627.13 ENSMUST00000047627.2 ENSMUST00000047627.3 ENSMUST00000047627.4 ENSMUST00000047627.5 ENSMUST00000047627.6 ENSMUST00000047627.7 ENSMUST00000047627.8 ENSMUST00000047627.9 GPBP1_MOUSE Gpbp NM_028487 Q3TQR2 Q3TSN7 Q6NXH3 Q6TYE7 Q8C498 Q8R252 uc007rvw.1 uc007rvw.2 uc007rvw.3 uc007rvw.4 Functions as a GC-rich promoter-specific transactivating transcription factor. Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6NXH3-1; Sequence=Displayed; Name=2; IsoId=Q6NXH3-2; Sequence=VSP_032139; Name=3; IsoId=Q6NXH3-3; Sequence=VSP_032138, VSP_032139; Ubiquitously expressed (at protein level). Belongs to the vasculin family. Sequence=AAH16083.1; Type=Erroneous initiation; Evidence=; DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytosol plasma membrane transcription, DNA-templated regulation of transcription, DNA-templated intracellular membrane-bounded organelle positive regulation of transcription, DNA-templated uc007rvw.1 uc007rvw.2 uc007rvw.3 uc007rvw.4 
ENSMUST00000047629.7 Utp4 ENSMUST00000047629.7 UTP4 small subunit processome component, transcript variant 1 (from RefSeq NM_011574.2) Cirh1a ENSMUST00000047629.1 ENSMUST00000047629.2 ENSMUST00000047629.3 ENSMUST00000047629.4 ENSMUST00000047629.5 ENSMUST00000047629.6 Kiaa1988 NM_011574 Q62306 Q62307 Q69Z48 Q6NVG9 Q8R2N2 Q8VEL5 Tex292 UTP4_MOUSE uc009ngr.1 uc009ngr.2 uc009ngr.3 uc009ngr.4 Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted d Involved in SSU pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Interacts with HIVEP1 Interacts with NOL11. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75. Nucleus, nucleolus Chromosome Note=Found predominantly at the fibrillar center. Expressed in liver. In 11.5 day embryos, highly and predominantly expressed in liver, with lower expression in somites, brain and craniofacial structures. Expression significantly decreases in 12.5 day embryos and in the newborn. May be phosphorylated during mitosis; may control the association of this protein with WRD43 and UTP15. Sequence=AAH27399.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32596.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAA56628.1; Type=Frameshift; Evidence=; Sequence=CAA56629.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAA56629.1; Type=Frameshift; Evidence=; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) fibrillar center nucleus chromosome nucleolus regulation of transcription, DNA-templated rRNA processing maturation of SSU-rRNA 90S preribosome small-subunit processome t-UTP complex ribosome biogenesis uc009ngr.1 uc009ngr.2 uc009ngr.3 uc009ngr.4 
ENSMUST00000047630.7 Actrt3 ENSMUST00000047630.7 actin related protein T3 (from RefSeq NM_029690.3) ACTT3_MOUSE Arpm1 ENSMUST00000047630.1 ENSMUST00000047630.2 ENSMUST00000047630.3 ENSMUST00000047630.4 ENSMUST00000047630.5 ENSMUST00000047630.6 NM_029690 Q3KNH6 Q8BXF8 Q9D9A6 uc008ouw.1 uc008ouw.2 uc008ouw.3 Interacts with PFN3. Q8BXF8; Q9DAD6: Pfn3; NbExp=3; IntAct=EBI-6480313, EBI-6480328; Cytoplasm, cytoskeleton Cytoplasm Nucleus Note=The localization changes from the peripheral region to inside the nucleus during differentiation from round to elongated spermatid. Testis specific (at protein level). Expressed specifically in haploid germ cells. Belongs to the actin family. Sequence=BAB24897.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; male germ cell nucleus protein binding nucleus cytoplasm cytoskeleton actin cytoskeleton uc008ouw.1 uc008ouw.2 uc008ouw.3 
ENSMUST00000047632.14 Surf6 ENSMUST00000047632.14 surfeit gene 6 (from RefSeq NM_009298.4) ENSMUST00000047632.1 ENSMUST00000047632.10 ENSMUST00000047632.11 ENSMUST00000047632.12 ENSMUST00000047632.13 ENSMUST00000047632.2 ENSMUST00000047632.3 ENSMUST00000047632.4 ENSMUST00000047632.5 ENSMUST00000047632.6 ENSMUST00000047632.7 ENSMUST00000047632.8 ENSMUST00000047632.9 NM_009298 Q3V1X4 Q3V1X4_MOUSE Surf6 uc008iwc.1 uc008iwc.2 uc008iwc.3 Belongs to the SURF6 family. uc008iwc.1 uc008iwc.2 uc008iwc.3 
ENSMUST00000047652.6 Tspan14 ENSMUST00000047652.6 tetraspanin 14, transcript variant 4 (from RefSeq NR_188878.1) D14Ertd226e ENSMUST00000047652.1 ENSMUST00000047652.2 ENSMUST00000047652.3 ENSMUST00000047652.4 ENSMUST00000047652.5 NR_188878 Q8QZY6 TSN14_MOUSE Tm4sf14 uc007tch.1 uc007tch.2 uc007tch.3 uc007tch.4 Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:23035126, PubMed:26668317). Negatively regulates ADAM10-mediated cleavage of GP6 (PubMed:26668317). Promotes ADAM10- mediated cleavage of CDH5 (PubMed:23035126). Interacts with ADAM10; the interaction promotes ADAM10 maturation and cell surface expression. Cell membrane ; Multi-pass membrane protein Belongs to the tetraspanin (TM4SF) family. plasma membrane integral component of plasma membrane cell surface membrane integral component of membrane enzyme binding positive regulation of Notch signaling pathway protein maturation protein localization to plasma membrane tetraspanin-enriched microdomain uc007tch.1 uc007tch.2 uc007tch.3 uc007tch.4 
ENSMUST00000047655.7 Slc25a43 ENSMUST00000047655.7 solute carrier family 25, member 43, transcript variant 3 (from RefSeq NR_075097.1) A2A3V2 B2RWC0 ENSMUST00000047655.1 ENSMUST00000047655.2 ENSMUST00000047655.3 ENSMUST00000047655.4 ENSMUST00000047655.5 ENSMUST00000047655.6 Gm8 NR_075097 S2543_MOUSE uc009sxr.1 uc009sxr.2 uc009sxr.3 uc009sxr.4 Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. mitochondrion mitochondrial inner membrane membrane integral component of membrane transmembrane transporter activity transmembrane transport uc009sxr.1 uc009sxr.2 uc009sxr.3 uc009sxr.4 
ENSMUST00000047660.5 Pglyrp3 ENSMUST00000047660.5 peptidoglycan recognition protein 3 (from RefSeq NM_207247.4) A1A547 E9QMH8 ENSMUST00000047660.1 ENSMUST00000047660.2 ENSMUST00000047660.3 ENSMUST00000047660.4 Gm420 NM_207247 PGRP3_MOUSE Pgrpia Q6R1Z2 uc008qdi.1 uc008qdi.2 uc008qdi.3 uc008qdi.4 Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity (By similarity). Monomer. Homodimer; disulfide-linked. Heterodimer with PGLYRP4; disulfide-linked (By similarity). Secreted Detected in lung, spleen and stomach, and at low levels in eye, heart, thymus and testis. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. pattern recognition receptor signaling pathway immune system process extracellular region extracellular space zinc ion binding N-acetylmuramoyl-L-alanine amidase activity peptidoglycan catabolic process peptidoglycan receptor activity detection of bacterium antimicrobial humoral response killing of cells of other organism negative regulation of interferon-gamma production negative regulation of natural killer cell differentiation involved in immune response macromolecular complex defense response to bacterium peptidoglycan binding growth of symbiont in host innate immune response protein heterodimerization activity defense response to Gram-positive bacterium positive regulation of cytolysis in other organism uc008qdi.1 uc008qdi.2 uc008qdi.3 uc008qdi.4 
ENSMUST00000047664.16 Arhgef4 ENSMUST00000047664.16 Rho guanine nucleotide exchange factor 4, transcript variant 2 (from RefSeq NM_183019.3) ARHG4_MOUSE ENSMUST00000047664.1 ENSMUST00000047664.10 ENSMUST00000047664.11 ENSMUST00000047664.12 ENSMUST00000047664.13 ENSMUST00000047664.14 ENSMUST00000047664.15 ENSMUST00000047664.2 ENSMUST00000047664.3 ENSMUST00000047664.4 ENSMUST00000047664.5 ENSMUST00000047664.6 ENSMUST00000047664.7 ENSMUST00000047664.8 ENSMUST00000047664.9 Kiaa1112 NM_183019 Q7TNR9 Q80TJ6 uc007api.1 uc007api.2 uc007api.3 Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Interacts with RHOA and RAC1, and APC. Found in a complex consisting of ARHGEF4, APC and CTNNB1 (By similarity). Cytoplasm Note=Colocalized with APC in the synapse of olfactory glomerulus. Expressed in colon epithelial cells. Highly expressed in CNS, including hippocampus, olfactory bulb and cerebellum. Expression is aberrantly enhanced in most colorectal tumors. In an autoinhibited form the SH3 domain binds intramolecularly to the DH domain, thus blocking the Rac-binding site. Sequence=BC055804; Type=Frameshift; Evidence=; guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cytoplasm protein domain specific binding lamellipodium assembly Rac guanyl-nucleotide exchange factor activity regulation of Rho protein signal transduction intracellular signal transduction filopodium assembly uc007api.1 uc007api.2 uc007api.3 
ENSMUST00000047666.5 Pgm5 ENSMUST00000047666.5 phosphoglucomutase 5 (from RefSeq NM_175013.2) ENSMUST00000047666.1 ENSMUST00000047666.2 ENSMUST00000047666.3 ENSMUST00000047666.4 NM_175013 PGM5_MOUSE Pgm5 Q8BZF8 uc008has.1 uc008has.2 uc008has.3 Component of adherens-type cell-cell and cell-matrix junctions. Has no phosphoglucomutase activity in vitro. Interacts with DMD/dystrophin; the interaction is direct (PubMed:7890770). Interacts with UTRN/utrophin (By similarity). Cell junction, adherens junction Cytoplasm, cytoskeleton Cell membrane, sarcolemma Note=Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments. Belongs to the phosphohexose mutase family. Sequence=BAC29083.1; Type=Erroneous initiation; Evidence=; magnesium ion binding stress fiber phosphoglucomutase activity protein binding cytoplasm cytosol cytoskeleton adherens junction cell-cell adherens junction spot adherens junction focal adhesion carbohydrate metabolic process glucose metabolic process cell adhesion cytoplasmic side of plasma membrane intercalated disc striated muscle tissue development dystrophin-associated glycoprotein complex Z disc cell junction cell-substrate junction myofibril assembly sarcolemma costamere metal ion binding organic substance metabolic process intramolecular transferase activity, phosphotransferases uc008has.1 uc008has.2 uc008has.3 
ENSMUST00000047672.9 Cct2 ENSMUST00000047672.9 chaperonin containing TCP1 subunit 2, transcript variant 1 (from RefSeq NM_007636.3) Cct2 ENSMUST00000047672.1 ENSMUST00000047672.2 ENSMUST00000047672.3 ENSMUST00000047672.4 ENSMUST00000047672.5 ENSMUST00000047672.6 ENSMUST00000047672.7 ENSMUST00000047672.8 NM_007636 Q542X7 Q542X7_MOUSE uc007hcs.1 uc007hcs.2 uc007hcs.3 Cytoplasm Belongs to the TCP-1 chaperonin family. nucleotide binding ATP binding cytoplasm cytosol chaperonin-containing T-complex microtubule protein folding ubiquitin protein ligase binding positive regulation of telomere maintenance via telomerase protein binding involved in protein folding protein stabilization unfolded protein binding chaperone mediated protein folding independent of cofactor chaperone-mediated protein complex assembly positive regulation of telomerase activity scaRNA localization to Cajal body positive regulation of establishment of protein localization to telomere positive regulation of telomerase RNA localization to Cajal body uc007hcs.1 uc007hcs.2 uc007hcs.3 
ENSMUST00000047677.9 Ccdc18 ENSMUST00000047677.9 coiled-coil domain containing 18 (from RefSeq NM_028481.1) CCD18_MOUSE ENSMUST00000047677.1 ENSMUST00000047677.2 ENSMUST00000047677.3 ENSMUST00000047677.4 ENSMUST00000047677.5 ENSMUST00000047677.6 ENSMUST00000047677.7 ENSMUST00000047677.8 NM_028481 Q640L5 Q8BIM9 Q8BIN1 Q9DA43 uc008ynr.1 uc008ynr.2 uc008ynr.3 uc008ynr.4 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q640L5-1; Sequence=Displayed; Name=2; IsoId=Q640L5-2; Sequence=VSP_024642, VSP_024643; Name=3; IsoId=Q640L5-3; Sequence=VSP_024641; Name=4; IsoId=Q640L5-4; Sequence=VSP_024637, VSP_024638, VSP_024639, VSP_024640; molecular_function cellular_component biological_process uc008ynr.1 uc008ynr.2 uc008ynr.3 uc008ynr.4 
ENSMUST00000047687.9 Entpd3 ENSMUST00000047687.9 ectonucleoside triphosphate diphosphohydrolase 3 (from RefSeq NM_178676.5) E9PYV0 ENSMUST00000047687.1 ENSMUST00000047687.2 ENSMUST00000047687.3 ENSMUST00000047687.4 ENSMUST00000047687.5 ENSMUST00000047687.6 ENSMUST00000047687.7 ENSMUST00000047687.8 ENTP3_MOUSE Entpd3 NM_178676 Q3TC04 Q3TDX3 Q8BFW6 uc009scq.1 uc009scq.2 uc009scq.3 uc009scq.4 Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates (PubMed:15130768). Has a threefold preference for the hydrolysis of ATP and UTP over ADP and UDP (PubMed:15130768). Reaction=a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:36795, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.5; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Kinetic parameters: KM=11 mM for ATP (at pH 7.4) ; KM=10 mM for UTP (at pH 7.4) ; KM=19 mM for ADP (at pH 7.4) ; KM=27 mM for UDP (at pH 7.4) ; Cell membrane ; Multi-pass membrane protein Belongs to the GDA1/CD39 NTPase family. plasma membrane nucleoside diphosphate catabolic process nucleoside triphosphate catabolic process membrane integral component of membrane dephosphorylation hydrolase activity nucleoside-diphosphatase activity nucleoside-triphosphatase activity 8-oxo-dGTP phosphohydrolase activity 5'-nucleotidase activity uc009scq.1 uc009scq.2 uc009scq.3 uc009scq.4 
ENSMUST00000047704.8 Cep78 ENSMUST00000047704.8 centrosomal protein 78 (from RefSeq NM_198019.2) CEP78_MOUSE ENSMUST00000047704.1 ENSMUST00000047704.2 ENSMUST00000047704.3 ENSMUST00000047704.4 ENSMUST00000047704.5 ENSMUST00000047704.6 ENSMUST00000047704.7 NM_198019 Q6IRU7 uc008gwr.1 uc008gwr.2 uc008gwr.3 May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis. Interacts with PLK4. Interacts with FAM161A. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body Note=Mainly localizes at the centriolar wall, but also found in the pericentriolar material. Expressed in photoreceptor inner segment. Expressed by photoreceptor cells in the retina. Expressed at all stages of development with higher expression during embryogenesis. Belongs to the CEP78 family. molecular_function cytoplasm centrosome centriole microtubule organizing center cytoskeleton cilium cell projection organization ciliary basal body cell projection cilium organization uc008gwr.1 uc008gwr.2 uc008gwr.3 
ENSMUST00000047711.13 Vezt ENSMUST00000047711.13 vezatin, adherens junctions transmembrane protein, transcript variant 1 (from RefSeq NM_172538.5) A0M8X3 ENSMUST00000047711.1 ENSMUST00000047711.10 ENSMUST00000047711.11 ENSMUST00000047711.12 ENSMUST00000047711.2 ENSMUST00000047711.3 ENSMUST00000047711.4 ENSMUST00000047711.5 ENSMUST00000047711.6 ENSMUST00000047711.7 ENSMUST00000047711.8 ENSMUST00000047711.9 NM_172538 Q3ZK21 Q3ZK22 Q8BY12 Q8BYB4 Q8BZB5 VEZA_MOUSE Vezt uc007gvh.1 uc007gvh.2 uc007gvh.3 uc007gvh.4 This gene encodes a transmembrane protein that is essential for the formation of adherens junctions. It is required for both the pre-implantation morphogenesis of a blastocyst and for the implantation process. The encoded protein is also a component of the ankle-link complex in cochlear hair cells, where it may effect resilience to sound trauma. It is also thought to be involved in dendritic spine morphogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]. Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. Interacts with USH2A (via the cytoplasmic region); the interaction associates VEZT with the USH2 complex at the stereocilia base (PubMed:17567809). Interacts with myosin MYO7A and the cadherin- catenins complex (By similarity). Cell membrane ; Multi-pass membrane protein Cell projection, stereocilium membrane Cell junction, adherens junction Nucleus Cytoplasmic vesicle, secretory vesicle, acrosome Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=2.4; IsoId=Q3ZK22-1; Sequence=Displayed; Name=2; Synonyms=0.8; IsoId=Q3ZK22-2; Sequence=VSP_035268, VSP_035269, VSP_035270; Name=3; Synonyms=1.9; IsoId=Q3ZK22-3; Sequence=VSP_035272, VSP_035273; Name=4; IsoId=Q3ZK22-4; Sequence=VSP_035271, VSP_035274; Expressed in developing cochlear hair cells (PubMed:17567809). Isoform 1, isoform 2 and isoform 3 are expressed in testis. In the seminiferous epithelium, present exclusively in the acrosome of spermatids (at protein level). Present in oocytes and at every embryonic stage (at protein level). Embryos die at the time of implantation because of a defect in intercellular adhesion. Belongs to the vezatin family. acrosomal vesicle stereocilia ankle link complex protein binding nucleus nucleoplasm cytosol plasma membrane adherens junction multicellular organism development membrane integral component of membrane myosin binding cell junction cytoplasmic vesicle cell projection chordate embryonic development stereocilium membrane cell-cell adhesion uc007gvh.1 uc007gvh.2 uc007gvh.3 uc007gvh.4 
ENSMUST00000047714.14 Kdm5b ENSMUST00000047714.14 lysine demethylase 5B (from RefSeq NM_152895.2) ENSMUST00000047714.1 ENSMUST00000047714.10 ENSMUST00000047714.11 ENSMUST00000047714.12 ENSMUST00000047714.13 ENSMUST00000047714.2 ENSMUST00000047714.3 ENSMUST00000047714.4 ENSMUST00000047714.5 ENSMUST00000047714.6 ENSMUST00000047714.7 ENSMUST00000047714.8 ENSMUST00000047714.9 Jarid1b KDM5B_MOUSE Kiaa4034 NM_152895 Plu1 Q5DTR9 Q80Y84 Q8BLU1 Q8JZL8 uc011wsg.1 uc011wsg.2 uc011wsg.3 This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY082429.1, AY082430.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Represses the CLOCK-BMAL1 heterodimer- mediated transcriptional activation of the core clock component PER2. Reaction=3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)- [histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate; Xref=Rhea:RHEA:60208, Rhea:RHEA-COMP:15537, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61961; EC=1.14.11.67; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Interacts (via PHD-type 1 zinc finger) with histone H3 unmodified at 'Lys-4'; the interaction is inhibited when histone H3 is methylated at 'Arg-2' or 'Lys-4' (By similarity). Q80Y84; P60762: Morf4l1; NbExp=4; IntAct=EBI-1249551, EBI-2943018; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80Y84-1; Sequence=Displayed; Name=2; IsoId=Q80Y84-2; Sequence=VSP_026409; Present at highest levels in testis, where it is enriched in spermatogonia and pachytene cells (at protein level). Expressed in developing brain, mammary bud, thymus, teeth, whisker follicle, intervertebral disks, olfactory epithelium, eye, stomach and limbs. Both the JmjC domain and the JmjN domain are required for enzymatic activity. However ARID and PHD-type 1 domain are not required for activity per se but contributed to recognition of the H3(1-21)K4me2 substrate peptide. The 2 first PHD-type zinc finger domains are required for transcription repression activity. Homozygous KDM5B-null mice are subviable, exhibit vertebral patterning defects, and manifest numerous behavioral abnormalities including increased anxiety, less sociability, and reduced long-term memory compared with that of wild-types. Heterozygous mice appear normal. Belongs to the JARID1 histone demethylase family. Sequence=BAD90482.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; DNA binding transcription corepressor activity protein binding nucleus cytosol chromatin organization chromatin remodeling single fertilization zinc ion binding post-embryonic development positive regulation of gene expression oxidoreductase activity histone demethylase activity histone demethylase activity (H3-K4 specific) positive regulation of mammary gland epithelial cell proliferation histone demethylase activity (H3-trimethyl-K4 specific) histone demethylase activity (H3-dimethyl-K4 specific) histone H3-K4 demethylation histone H3-K4 demethylation, trimethyl-H3-K4-specific histone methyltransferase complex histone binding regulation of circadian rhythm cellular response to fibroblast growth factor stimulus negative regulation of transcription, DNA-templated metal ion binding rhythmic process dioxygenase activity oxidation-reduction process branching involved in mammary gland duct morphogenesis mammary duct terminal end bud growth response to fungicide uterus morphogenesis lens fiber cell differentiation cellular response to leukemia inhibitory factor sequence-specific double-stranded DNA binding regulation of estradiol secretion uc011wsg.1 uc011wsg.2 uc011wsg.3 
ENSMUST00000047720.9 Disp3 ENSMUST00000047720.9 dispatched RND transporter family member 3, transcript variant 3 (from RefSeq NR_154985.1) Disp3 E9QL24 E9QL24_MOUSE ENSMUST00000047720.1 ENSMUST00000047720.2 ENSMUST00000047720.3 ENSMUST00000047720.4 ENSMUST00000047720.5 ENSMUST00000047720.6 ENSMUST00000047720.7 ENSMUST00000047720.8 NR_154985 Ptchd2 uc008vum.1 uc008vum.2 uc008vum.3 cytoplasm membrane integral component of membrane negative regulation of neuron differentiation positive regulation of lipid metabolic process positive regulation of neural precursor cell proliferation uc008vum.1 uc008vum.2 uc008vum.3 
ENSMUST00000047721.10 Rrp9 ENSMUST00000047721.10 ribosomal RNA processing 9, U3 small nucleolar RNA binding protein (from RefSeq NM_145620.4) ENSMUST00000047721.1 ENSMUST00000047721.2 ENSMUST00000047721.3 ENSMUST00000047721.4 ENSMUST00000047721.5 ENSMUST00000047721.6 ENSMUST00000047721.7 ENSMUST00000047721.8 ENSMUST00000047721.9 NM_145620 Q8CFB7 Q91WM3 Rnu3ip2 U3-55k U3IP2_MOUSE uc009rkb.1 uc009rkb.2 uc009rkb.3 Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Interacts specifically with the U3 small nucleolar RNA (U3 snoRNA). Binds a sub-fragment of the U3 snoRNA surrounding the B/C motif (3UBC). This association with the U3BC RNA is dependent on the binding of a protein called 15.5K to the box B/C motif. The association of the protein with the U3BC RNA was found to be also dependent on a conserved RNA structure that flanks the box B/C motif. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus The WD domains are required for nucleolar localization and U3 small nucleolar RNAs binding. Acetylation at Lys-12 and Lys-25 by KAT2B/PCAF under stress impairs pre-rRNA processing. Deacetylation by SIRT7 enhances RRP9- binding to U3 snoRNA, which is a prerequisite for pre-rRNA processing. Belongs to the WD repeat RRP9 family. RNA binding nucleus nucleolus rRNA processing box C/D snoRNP complex small-subunit processome U3 snoRNA binding uc009rkb.1 uc009rkb.2 uc009rkb.3 
ENSMUST00000047726.12 Slc39a2 ENSMUST00000047726.12 solute carrier family 39 (zinc transporter), member 2 (from RefSeq NM_001039676.2) ENSMUST00000047726.1 ENSMUST00000047726.10 ENSMUST00000047726.11 ENSMUST00000047726.2 ENSMUST00000047726.3 ENSMUST00000047726.4 ENSMUST00000047726.5 ENSMUST00000047726.6 ENSMUST00000047726.7 ENSMUST00000047726.8 ENSMUST00000047726.9 G3X943 NM_001039676 Q2HIZ9 S39A2_MOUSE Zip2 uc007tnj.1 uc007tnj.2 uc007tnj.3 Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:14525987). The Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential. Transports also other divalent cations Zn(2+), Cd2(+), Cu2(+), Co2(+) in the order of decreasing affinity, respectively (By similarity). In the skin, aids in the differentiation of keratinocytes in the epidermis (PubMed:24936057). Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29353; Evidence=; Reaction=Cd(2+)(in) = Cd(2+)(out); Xref=Rhea:RHEA:28707, ChEBI:CHEBI:48775; Evidence=; Kinetic parameters: KM=1.6 uM for Zn(2+) ; Cell membrane ; Multi-pass membrane protein High expression in the liver, skin and ovary. Up-regulated upon the induction of differentiation in cultured keratinocytes. Deficient mice do not reveal any specific phenotype, however these mice are more susceptible to abnormal embryonic development because of zinc deficiency during pregnancy. Belongs to the ZIP transporter (TC 2.A.5) family. It was previously proposed that SLC39A2 operates as a Zn2(+)/HCO3(-) symport mechanism (By similarity). However in more recent studies, SLC39A2-mediated transport is independent of both HCO3(-) and H(+)-driving forces, but modulated by extracellular pH and voltage (By similarity). zinc ion transmembrane transporter activity plasma membrane zinc II ion transport membrane integral component of membrane metal ion transport cytoplasmic vesicle metal ion transmembrane transporter activity transmembrane transport zinc II ion transmembrane transport uc007tnj.1 uc007tnj.2 uc007tnj.3 
ENSMUST00000047737.10 Irf8 ENSMUST00000047737.10 interferon regulatory factor 8, transcript variant 2 (from RefSeq NM_008320.4) ENSMUST00000047737.1 ENSMUST00000047737.2 ENSMUST00000047737.3 ENSMUST00000047737.4 ENSMUST00000047737.5 ENSMUST00000047737.6 ENSMUST00000047737.7 ENSMUST00000047737.8 ENSMUST00000047737.9 Icsbp1 Irf8 NM_008320 Q544J7 Q544J7_MOUSE uc009nrk.1 uc009nrk.2 uc009nrk.3 uc009nrk.4 The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter cellular response to interferon-gamma uc009nrk.1 uc009nrk.2 uc009nrk.3 uc009nrk.4 
ENSMUST00000047740.4 Upk2 ENSMUST00000047740.4 uroplakin 2 (from RefSeq NM_009476.2) ENSMUST00000047740.1 ENSMUST00000047740.2 ENSMUST00000047740.3 NM_009476 Q3SXK0 Q3SXK0_MOUSE Upk2 uc009pds.1 uc009pds.2 uc009pds.3 membrane integral component of membrane epithelial cell differentiation uc009pds.1 uc009pds.2 uc009pds.3 
ENSMUST00000047745.6 Pglyrp4 ENSMUST00000047745.6 peptidoglycan recognition protein 4, transcript variant 2 (from RefSeq NM_207263.3) ENSMUST00000047745.1 ENSMUST00000047745.2 ENSMUST00000047745.3 ENSMUST00000047745.4 ENSMUST00000047745.5 NM_207263 PGRP4_MOUSE Pgrpib Q0VB07 Q6R1Z1 uc008qdg.1 uc008qdg.2 uc008qdg.3 uc008qdg.4 Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity (By similarity). Homodimer; disulfide-linked. Heterodimer with PGLYRP3; disulfide-linked (By similarity). Secreted Ubiquitous. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. pattern recognition receptor signaling pathway immune system process extracellular region extracellular space zinc ion binding N-acetylmuramoyl-L-alanine amidase activity peptidoglycan catabolic process peptidoglycan receptor activity detection of bacterium antimicrobial humoral response killing of cells of other organism negative regulation of interferon-gamma production negative regulation of natural killer cell differentiation involved in immune response macromolecular complex defense response to bacterium peptidoglycan binding growth of symbiont in host innate immune response protein heterodimerization activity defense response to Gram-positive bacterium positive regulation of cytolysis in other organism uc008qdg.1 uc008qdg.2 uc008qdg.3 uc008qdg.4 
ENSMUST00000047749.7 4921524J17Rik ENSMUST00000047749.7 RIKEN cDNA 4921524J17 gene, transcript variant 2 (from RefSeq NR_033144.1) CP087_MOUSE ENSMUST00000047749.1 ENSMUST00000047749.2 ENSMUST00000047749.3 ENSMUST00000047749.4 ENSMUST00000047749.5 ENSMUST00000047749.6 NR_033144 Q9CR55 uc009mpv.1 uc009mpv.2 uc009mpv.3 uc009mpv.4 Belongs to the UPF0547 family. molecular_function cellular_component biological_process uc009mpv.1 uc009mpv.2 uc009mpv.3 uc009mpv.4 
ENSMUST00000047753.5 Abcb1a ENSMUST00000047753.5 ATP-binding cassette, sub-family B member 1A (from RefSeq NM_011076.3) Abcb1a Abcb4 ENSMUST00000047753.1 ENSMUST00000047753.2 ENSMUST00000047753.3 ENSMUST00000047753.4 MDR1A_MOUSE Mdr1a Mdr3 NM_011076 P21447 Pgy-3 Pgy3 Q5I1Y5 uc008wkl.1 uc008wkl.2 uc008wkl.3 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.196846.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN00849387 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D- glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug- resistant cells (By similarity). Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.; EC=7.6.2.2; Evidence=; Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:36439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:64612, ChEBI:CHEBI:456216; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38583, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57643, ChEBI:CHEBI:456216; Evidence=; Reaction=a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38943, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:22801, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Reaction=a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38903, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Translocase activity is inhibited by verapamil and is sensitive to energy depletion. C1orf115 regulates drug efflux through modulation of ABCB1 localization and activity. Interacts with PSMB5. Cell membrane ; Multi-pass membrane protein Apical cell membrane Cytoplasm Note=ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). In mouse the MDR gene family includes three or more related but distinct cellular genes. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. G2/M transition of mitotic cell cycle nucleotide binding ATP binding plasma membrane drug transmembrane transport xenobiotic-transporting ATPase activity hormone transport cell surface membrane integral component of membrane apical plasma membrane ATPase activity brush border membrane carbohydrate export maintenance of permeability of blood-brain barrier ATPase activity, coupled ATPase activity, coupled to transmembrane movement of substances daunorubicin transport apical part of cell phospholipid translocation intercellular canaliculus drug export regulation of response to osmotic stress intestinal absorption transmembrane transport negative regulation of cell death establishment of blood-brain barrier stem cell proliferation phosphatidylcholine-translocating ATPase activity phosphatidylethanolamine-translocating ATPase activity ceramide-translocating ATPase activity ceramide translocation positive regulation of anion channel activity protein localization to bicellular tight junction positive regulation of establishment of Sertoli cell barrier regulation of intestinal absorption drug transmembrane export drug transport across blood-brain barrier establishment of blood-retinal barrier positive regulation of response to drug regulation of chloride transport uc008wkl.1 uc008wkl.2 uc008wkl.3 
ENSMUST00000047760.10 Spsb2 ENSMUST00000047760.10 splA/ryanodine receptor domain and SOCS box containing 2, transcript variant 3 (from RefSeq NM_001306051.2) ENSMUST00000047760.1 ENSMUST00000047760.2 ENSMUST00000047760.3 ENSMUST00000047760.4 ENSMUST00000047760.5 ENSMUST00000047760.6 ENSMUST00000047760.7 ENSMUST00000047760.8 ENSMUST00000047760.9 Grcc9 NM_001306051 O88838 Q8CBA5 Q91Z15 SPSB2_MOUSE Ssb2 uc009drw.1 uc009drw.2 uc009drw.3 uc009drw.4 This gene encodes a member of the SSB family of proteins that contain a central SPRY (repeats in splA and ryanodine receptors) domain and a C-terminal SOCS (suppressor of cytokine signaling) box. The encoded protein is an adaptor protein in the E3 ubiquitin ligase complex that ubiquitinates inducible nitric oxide synthase and targets it for proteasomal degradation. Mice lacking the encoded protein exhibit lower blood urea nitrogen levels and mild thrombocytopenia due to reduced platelet production. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20603330). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:20603330). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). Protein modification; protein ubiquitination. Component of the probable ECS(SPSB2) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB2 (By similarity). Interacts with CUL5, RNF7, ELOB and ELOC (By similarity). Interacts with MET (PubMed:16369487). Interacts (via B30.2/SPRY domain) with PAWR; this interaction occurs in association with the Elongin BC complex (PubMed:16369487, PubMed:20561531). Interacts with NOS2. O88838; Q96IZ0: PAWR; Xeno; NbExp=6; IntAct=EBI-8820410, EBI-595869; Cytoplasm Cytoplasm, cytosol Note=Exhibits a diffuse cytosolic localization. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88838-1; Sequence=Displayed; Name=2; IsoId=O88838-2; Sequence=VSP_018613; The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). Essential for its ability to link NOS2 and the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). Belongs to the SPSB family. protein binding cytoplasm cytosol ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex intracellular signal transduction proteasome-mediated ubiquitin-dependent protein catabolic process protein binding, bridging involved in substrate recognition for ubiquitination uc009drw.1 uc009drw.2 uc009drw.3 uc009drw.4 
ENSMUST00000047762.10 Gata6 ENSMUST00000047762.10 GATA binding protein 6 (from RefSeq NM_010258.3) ENSMUST00000047762.1 ENSMUST00000047762.2 ENSMUST00000047762.3 ENSMUST00000047762.4 ENSMUST00000047762.5 ENSMUST00000047762.6 ENSMUST00000047762.7 ENSMUST00000047762.8 ENSMUST00000047762.9 GATA6_MOUSE NM_010258 P97729 Q3UQJ2 Q61169 Q9QZK3 uc008ebk.1 uc008ebk.2 uc008ebk.3 Transcriptional activator that regulates SEMA3C and PLXNA2 (PubMed:19666519). May regulate genes that protect epithelial cells from bacterial infection (By similarity). Involved in gene regulation specifically in the gastric epithelium (By similarity). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343). Interacts with LMCD1. Nucleus Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=Q61169-1; Sequence=Displayed; Name=2; IsoId=Q61169-2; Sequence=VSP_035779; Expressed in myocardium, vascular smooth muscle, gut epithelium, and osteoclasts. The GATA-type zinc fingers mediate interaction with LMCD1. [Isoform 2]: Produced by alternative initiation at Met- 147 of isoform 1. Sequence=AAB37426.1; Type=Frameshift; Evidence=; Sequence=AAC52841.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II repressing transcription factor binding enhancer sequence-specific DNA binding in utero embryonic development liver development outflow tract septum morphogenesis type B pancreatic cell differentiation pancreatic A cell differentiation DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated transcription from RNA polymerase II promoter phospholipid metabolic process endodermal cell fate determination transcription factor binding zinc ion binding male gonad development regulation of gene expression positive regulation of cardiac muscle cell apoptotic process cardiac muscle hypertrophy in response to stress protein kinase binding positive regulation of BMP signaling pathway epithelial cell differentiation pancreas development nuclear membrane negative regulation of transforming growth factor beta1 production negative regulation of transforming growth factor beta2 production tube morphogenesis endodermal cell differentiation response to drug positive regulation of apoptotic process negative regulation of apoptotic process sequence-specific DNA binding response to estrogen transcription regulatory region DNA binding positive regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding animal organ formation cardiac muscle tissue development smooth muscle cell differentiation positive regulation of cardioblast differentiation cardiac muscle cell differentiation positive regulation of cardiac muscle cell proliferation lung saccule development Clara cell differentiation Type II pneumocyte differentiation intestinal epithelial cell differentiation cardiac vascular smooth muscle cell differentiation response to growth factor positive regulation of cell cycle arrest cellular response to gonadotropin stimulus cellular response to hypoxia cellular response to BMP stimulus negative regulation of pri-miRNA transcription from RNA polymerase II promoter uc008ebk.1 uc008ebk.2 uc008ebk.3 
ENSMUST00000047768.11 Neil3 ENSMUST00000047768.11 nei like 3 (E. coli) (from RefSeq NM_146208.2) ENSMUST00000047768.1 ENSMUST00000047768.10 ENSMUST00000047768.2 ENSMUST00000047768.3 ENSMUST00000047768.4 ENSMUST00000047768.5 ENSMUST00000047768.6 ENSMUST00000047768.7 ENSMUST00000047768.8 ENSMUST00000047768.9 NEIL3_MOUSE NM_146208 Q4ADY6 Q8CD85 Q8K203 Q8R3P4 uc009lsa.1 uc009lsa.2 uc009lsa.3 DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5- OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161). No activity on 8-oxoG detected (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161). Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161). In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161). Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA- COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695, ChEBI:CHEBI:167181; EC=4.2.99.18; Evidence= Nucleus Chromosome Note=Recruited to replication stress sites via interaction with ubiquitinated CMG helicase. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K203-1; Sequence=Displayed; Name=2; IsoId=Q8K203-2; Sequence=VSP_012210; Expressed in testis, thymus, spleen and bone marrow. In young mice, expressed at higher levels in thymocytes than splenocytes. At 12 dpc, abundant in the subventricular zone (SVZ) of the lateral ventricles. At 17.5 dpc and P0, expression is limited to distinct cells in the cortical SVZ, in cells of the secondary matrix, the dentate gyrus migratory route and the dentate gyrus. Highly expressed in the developing brain at 12 dpc-13 dpc when neurogenesis starts. Expression decreases during later development and is undetectable in adult brain. By mitogen stimulation in splenocytes, and by hypoxic- ischemic injury in the striatum and hippocampus. The N-terminal region (2-282) contains the glycosylase and lyase activities. The RanBP2-type zinc-finger, also named NZF zinc finger, recognizes and binds ubiquitinated CMG helicase complex. The GRF-type zinc-fingers recognize single-stranded DNA (ssDNA), possibly on the lagging strand template. Perinatal mice show reduced regeneration of neural tissue following ischemic brain damage (stroke), associated with fewer activated microglia and impaired neural stem cell proliferation. Aged mice show deficits in learning and memory, decreased anxiety-like behavior, and changes in hippocampal synapse composition. Otherwise viable and fertile. [Isoform 2]: May be due to an intron retention. Belongs to the FPG family. Was originally thought to be inactive as a glycosylase, but recent reports demonstrate that cleavage of the initiator methionine is essential for catalytic activity. bubble DNA binding nucleic acid binding DNA binding damaged DNA binding double-stranded DNA binding single-stranded DNA binding catalytic activity DNA-(apurinic or apyrimidinic site) lyase activity nucleus nucleoplasm DNA repair base-excision repair nucleotide-excision repair cellular response to DNA damage stimulus metabolic process zinc ion binding hydrolase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing N-glycosyl compounds lyase activity DNA N-glycosylase activity metal ion binding uc009lsa.1 uc009lsa.2 uc009lsa.3 
ENSMUST00000047783.14 Rpgrip1l ENSMUST00000047783.14 Rpgrip1-like (from RefSeq NM_173431.2) ENSMUST00000047783.1 ENSMUST00000047783.10 ENSMUST00000047783.11 ENSMUST00000047783.12 ENSMUST00000047783.13 ENSMUST00000047783.2 ENSMUST00000047783.3 ENSMUST00000047783.4 ENSMUST00000047783.5 ENSMUST00000047783.6 ENSMUST00000047783.7 ENSMUST00000047783.8 ENSMUST00000047783.9 FTM_MOUSE Ftm G3X958 NM_173431 Nphp8 Q8CG73 uc009msp.1 uc009msp.2 uc009msp.3 Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (By similarity). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins (PubMed:22927466). Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2 (PubMed:26150391). Interacts with NPHP4 and NPHP1; NPHP1, NPHP4 and RPGRIP1L are proposed to form a functional NPHP1-4-8 module localized to cell-cell contacts and the ciliary transition zone; NPHP4 mediates the interaction between NPHP1 and RPGRIP1L. Interacts with IQCB1; the interaction likely requires additional interactors (PubMed:21565611). Interacts with TBXA2R (via C-terminus), RPGR, NEK4. Interacts with NPHP4, INVS and DVL2; proposed to form a complex involved in DVL2 stabilization (By similarity). Interacts with PSMD2 (PubMed:26150391). Q8CG73; Q8BP00: Iqcb1; NbExp=2; IntAct=EBI-4281130, EBI-4282243; Q8CG73; P59240: Nphp4; NbExp=4; IntAct=EBI-4281130, EBI-4281265; Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cell junction, tight junction Note=In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions. Localizes to the ciliary transition zone. Ubiquitously expressed. Not found in heart and skin. Expression was detected throughout embryonic development as early as 8.5 dpc. Belongs to the RPGRIP1 family. in utero embryonic development establishment of planar polarity kidney development liver development protein binding nucleoplasm cytoplasm centrosome microtubule organizing center cytosol cytoskeleton axonemal microtubule plasma membrane cell-cell junction bicellular tight junction cilium axoneme establishment or maintenance of cell polarity determination of left/right symmetry brain development regulation of smoothened signaling pathway neural tube patterning telencephalon development cerebellum development lateral ventricle development olfactory bulb development corpus callosum development cell junction thromboxane A2 receptor binding photoreceptor connecting cilium developmental process limb morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis ciliary rootlet ciliary transition zone ciliary basal body cell projection camera-type eye development nose development negative regulation of G-protein coupled receptor protein signaling pathway pericardium development cilium assembly head development cochlea development non-motile cilium assembly uc009msp.1 uc009msp.2 uc009msp.3 
ENSMUST00000047786.6 Marchf4 ENSMUST00000047786.6 membrane associated ring-CH-type finger 4, transcript variant 2 (from RefSeq NM_001421087.1) ENSMUST00000047786.1 ENSMUST00000047786.2 ENSMUST00000047786.3 ENSMUST00000047786.4 ENSMUST00000047786.5 Kiaa1399 MARH4_MOUSE March4 NM_001421087 Q4QQN4 Q80TE3 uc007bkn.1 uc007bkn.2 uc007bkn.3 E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Golgi apparatus membrane ; Multi- pass membrane protein The RING-CH-type zinc finger domain is required for E3 ligase activity. Golgi membrane ubiquitin-protein transferase activity Golgi apparatus Golgi stack trans-Golgi network zinc ion binding membrane integral component of membrane protein ubiquitination transferase activity metal ion binding uc007bkn.1 uc007bkn.2 uc007bkn.3 
ENSMUST00000047793.6 Hoxd1 ENSMUST00000047793.6 homeobox D1 (from RefSeq NM_010467.2) ENSMUST00000047793.1 ENSMUST00000047793.2 ENSMUST00000047793.3 ENSMUST00000047793.4 ENSMUST00000047793.5 HXD1_MOUSE Hox-4.9 Hoxd-1 NM_010467 Q01822 Q0VBQ9 uc008kei.1 uc008kei.2 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Nucleus. Is first detected at the end of the late streak stage in presumptive lateral and extraembryonic mesoderm. During early neurogenesis, it is detected solely in lateral mesoderm. By late neurogenesis and through mid-gestation, it is found in a restricted region of presumed trunk neural crest and the dermatome. Belongs to the Antp homeobox family. Labial subfamily. DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development sensory perception of pain neuron differentiation sequence-specific DNA binding embryonic skeletal system development uc008kei.1 uc008kei.2 
ENSMUST00000047799.13 Acad11 ENSMUST00000047799.13 acyl-Coenzyme A dehydrogenase family, member 11 (from RefSeq NM_175324.4) A0A0R4J0I6 A0A0R4J0I6_MOUSE Acad11 ENSMUST00000047799.1 ENSMUST00000047799.10 ENSMUST00000047799.11 ENSMUST00000047799.12 ENSMUST00000047799.2 ENSMUST00000047799.3 ENSMUST00000047799.4 ENSMUST00000047799.5 ENSMUST00000047799.6 ENSMUST00000047799.7 ENSMUST00000047799.8 ENSMUST00000047799.9 NM_175324 uc009rhg.1 uc009rhg.2 uc009rhg.3 Reaction=H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:48216, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:64868, ChEBI:CHEBI:74281; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48217; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:47232, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:65052, ChEBI:CHEBI:74693; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47233; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA = (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:48220, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:90118, ChEBI:CHEBI:90119; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48221; Evidence=; Reaction=a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:44704, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:58856, ChEBI:CHEBI:65111; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44705; Evidence=; Reaction=docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47228, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:65059, ChEBI:CHEBI:74692; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47229; Evidence=; Reaction=eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47236, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57380, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:74691; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47237; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Lipid metabolism; fatty acid beta-oxidation. Homodimer. Membrane Mitochondrion membrane Belongs to the acyl-CoA dehydrogenase family. long-chain-acyl-CoA dehydrogenase activity nucleus peroxisome oxidoreductase activity, acting on the CH-CH group of donors very-long-chain-acyl-CoA dehydrogenase activity mitochondrial membrane fatty acid beta-oxidation using acyl-CoA dehydrogenase flavin adenine dinucleotide binding oxidation-reduction process medium-chain-acyl-CoA dehydrogenase activity uc009rhg.1 uc009rhg.2 uc009rhg.3 
ENSMUST00000047812.8 Dpp4 ENSMUST00000047812.8 dipeptidylpeptidase 4, transcript variant 1 (from RefSeq NM_010074.3) Cd26 DPP4_MOUSE ENSMUST00000047812.1 ENSMUST00000047812.2 ENSMUST00000047812.3 ENSMUST00000047812.4 ENSMUST00000047812.5 ENSMUST00000047812.6 ENSMUST00000047812.7 NM_010074 P28843 Q3U514 uc008jvg.1 uc008jvg.2 uc008jvg.3 Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.; EC=3.4.14.5; Evidence= Inhibited by GPC3 and diprotin A. Monomer. Homodimer. Heterodimer with Seprase (FAP). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Associates with collagen. Interacts with PTPRC; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes. Interacts (via extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity. Interacts with CAV1 (via the N-terminus); the interaction is direct. Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11. Interacts with IGF2R; the interaction is direct. Interacts with GPC3. [Dipeptidyl peptidase 4 soluble form]: Secreted. Note=Detected in the serum and the seminal fluid. Cell membrane; Single-pass type II membrane protein. Apical cell membrane ; Single-pass type II membrane protein Cell projection, invadopodium membrane ; Single-pass type II membrane protein Cell projection, lamellipodium membrane ; Single-pass type II membrane protein Cell junction Membrane raft Note=Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-cell in an interleukin-12-dependent activation. Its interaction with CAV1 is necessary for its translocation to membrane rafts. Colocalized with PTPRC in membrane rafts. Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion. Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (By similarity). The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing. N- and O-Glycosylated. Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation (By similarity). Belongs to the peptidase S9B family. DPPIV subfamily. virus receptor activity behavioral fear response response to hypoxia protease binding regulation of T cell mediated immunity aminopeptidase activity serine-type endopeptidase activity receptor binding collagen binding extracellular region endoplasmic reticulum Golgi apparatus plasma membrane proteolysis cell adhesion peptidase activity serine-type peptidase activity dipeptidyl-peptidase activity positive regulation of cell proliferation cell surface negative regulation of extracellular matrix disassembly membrane integral component of membrane apical plasma membrane hydrolase activity lamellipodium cell junction endocytic vesicle lamellipodium membrane T cell costimulation regulation of cell-cell adhesion mediated by integrin locomotory exploration behavior psychomotor behavior T cell activation peptide binding identical protein binding protein homodimerization activity cell projection endothelial cell migration membrane raft intercellular canaliculus viral entry into host cell establishment of localization invadopodium membrane uc008jvg.1 uc008jvg.2 uc008jvg.3 
ENSMUST00000047815.13 Slc9a8 ENSMUST00000047815.13 solute carrier family 9 (sodium/hydrogen exchanger), member 8, transcript variant 1 (from RefSeq NM_148929.3) A2A465 ENSMUST00000047815.1 ENSMUST00000047815.10 ENSMUST00000047815.11 ENSMUST00000047815.12 ENSMUST00000047815.2 ENSMUST00000047815.3 ENSMUST00000047815.4 ENSMUST00000047815.5 ENSMUST00000047815.6 ENSMUST00000047815.7 ENSMUST00000047815.8 ENSMUST00000047815.9 NM_148929 Nhe8 Q3UPR4 Q5WA59 Q8BIH8 Q8BJ27 Q8R4D1 SL9A8_MOUSE uc008nzp.1 uc008nzp.2 uc008nzp.3 uc008nzp.4 This gene encodes a member of the Na+/H+ exchanger (NHE) family of integral membrane transporter proteins. The encoded protein is expressed on the apical membrane of the intestinal epithelial cells and plays an important role in mucosal protection. Loss of the encoded protein in mice results in a decrease in the number of goblet and mucin-positive cells, disorganization of the mucin layer, and a decrease in mucosal pH in the colon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology (By similarity). Plays a crucial role in germ cells in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi- derived vesicles that form the acrosomal cap (PubMed:28476888, PubMed:25472965). Can also be active at the cell surface of specialized cells. In the small intestine, plays a major physiological role in transepithelial absorption of Na(+). Regulates intracellular pH homeostasis of intestinal epithelial cells (By similarity). Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins (PubMed:26505975, PubMed:23657568, PubMed:23220221). Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells) (PubMed:29958869, PubMed:25377091). Reaction=H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out); Xref=Rhea:RHEA:29419, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101; Evidence=; Golgi apparatus membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Endosome, multivesicular body membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, acrosome Note=Mainly localized to the mid- to trans-Golgi compartments but a proportion is also localized to multivesicular bodies (By similarity). Localized at the apical membrane in the gastrointestinal tract (By similarity). Recruitment to the plasma membrane upon acid stimulation (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R4D1-1; Sequence=Displayed; Name=2; IsoId=Q8R4D1-2; Sequence=VSP_009500; Name=3; IsoId=Q8R4D1-4; Sequence=VSP_009503, VSP_009504; Predominantly expressed in the liver, skeletal muscle, kidney, and testis (PubMed:12409279). Expressed in both renal cortex and medulla (PubMed:12409279). Detected throughout the entire gastrointestinal tract, with high expression detected in stomach, duodenum and ascending colon (PubMed:18209477). In gastric epithelium; expressed in the glands within the fundus and pylorus regions (PubMed:23220221). Expression is much higher in the stomach and jejunum in young mice compared with adult mice. The deficient mice have no obvious intestinal phenotype, show no defect in Na(+)-absorption, have normal serum Na(+) levels and no signs of diarrhea. Apically expressed Slc9a2 and Slc9a3 are increased in the small intestine of the Slc9a8-deficient mice in compensation (PubMed:22575219). Deficient mice have a reduced gastric mucosal surface pH, a higher incidence of developing gastric ulcer, and a decreased of mucin-2 (Muc2) expression (PubMed:23657568, PubMed:23220221). The intestinal mucosa in Slc9a8-deficient mice is prone to bacterial adhesion and penetration, which in turn promotes inflammation (PubMed:26505975, PubMed:23220221). Male knockout mice are infertile, have small testis, low testosterone levels, normal LH and FSH serum levels, however LH receptor (Lhcgr) is approximately 50% reduced. The spermatogenesise is also affected, deficient mice have round-headed spermatozoa and lack acrosomes (PubMed:25472965, PubMed:28476888). Knockout mice exhibit reduced tear production and increased corneal staining (PubMed:25377091). Knockdown Slc9a8 in adult retina leads to photoreceptor cell death (PubMed:25377091, PubMed:29958869). Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Golgi membrane Golgi apparatus ion transport cation transport potassium ion transport sodium ion transport regulation of pH antiporter activity solute:proton antiporter activity sodium:proton antiporter activity potassium:proton antiporter activity membrane integral component of membrane sodium ion transmembrane transport regulation of intracellular pH transmembrane transport potassium ion transmembrane transport anion transmembrane transport hydrogen ion transmembrane transport uc008nzp.1 uc008nzp.2 uc008nzp.3 uc008nzp.4 
ENSMUST00000047835.8 Scaf11 ENSMUST00000047835.8 SR-related CTD-associated factor 11, transcript variant 1 (from RefSeq NM_028148.3) E9PZM7 E9PZM7_MOUSE ENSMUST00000047835.1 ENSMUST00000047835.2 ENSMUST00000047835.3 ENSMUST00000047835.4 ENSMUST00000047835.5 ENSMUST00000047835.6 ENSMUST00000047835.7 NM_028148 Scaf11 uc007xkf.1 uc007xkf.2 uc007xkf.3 spliceosomal complex assembly RNA splicing, via transesterification reactions nucleus nucleoplasm nucleolus RNA splicing nuclear body uc007xkf.1 uc007xkf.2 uc007xkf.3 
ENSMUST00000047840.9 Prss40 ENSMUST00000047840.9 serine protease 40 (from RefSeq NM_009356.2) A6H6T1 E9QL09 ENSMUST00000047840.1 ENSMUST00000047840.2 ENSMUST00000047840.3 ENSMUST00000047840.4 ENSMUST00000047840.5 ENSMUST00000047840.6 ENSMUST00000047840.7 ENSMUST00000047840.8 NM_009356 O70170 PRS40_MOUSE Tesp2 uc007aox.1 uc007aox.2 uc007aox.3 uc007aox.4 May play an important role in the sperm/egg interaction; released during the acrosome reaction. Cytoplasmic vesicle, secretory vesicle, acrosome Secreted Expressed in testis. More specifically, abundantly expressed in the haploid round spermatid. There appears to be no human ortholog of this protein. Belongs to the peptidase S1 family. acrosomal vesicle serine-type endopeptidase activity extracellular region extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity cytoplasmic vesicle uc007aox.1 uc007aox.2 uc007aox.3 uc007aox.4 
ENSMUST00000047851.4 Defb7 ENSMUST00000047851.4 defensin beta 7 (from RefSeq NM_139220.1) DEFB7_MOUSE ENSMUST00000047851.1 ENSMUST00000047851.2 ENSMUST00000047851.3 NM_139220 Q91V70 uc009lar.1 uc009lar.2 Has bactericidal activity. Secreted Belongs to the beta-defensin family. LAP/TAP subfamily. extracellular region extracellular space chemotaxis defense response CCR6 chemokine receptor binding chemoattractant activity defense response to bacterium positive chemotaxis cell chemotaxis uc009lar.1 uc009lar.2 
ENSMUST00000047852.8 Fam199x ENSMUST00000047852.8 family with sequence similarity 199, X-linked (from RefSeq NM_146261.2) B1AZH1 ENSMUST00000047852.1 ENSMUST00000047852.2 ENSMUST00000047852.3 ENSMUST00000047852.4 ENSMUST00000047852.5 ENSMUST00000047852.6 ENSMUST00000047852.7 F199X_MOUSE NM_146261 Q3U3R2 Q8K2D0 uc009ujq.1 uc009ujq.2 uc009ujq.3 uc009ujq.4 Belongs to the FAM199 family. molecular_function cellular_component biological_process uc009ujq.1 uc009ujq.2 uc009ujq.3 uc009ujq.4 
ENSMUST00000047860.9 Noa1 ENSMUST00000047860.9 nitric oxide associated 1 (from RefSeq NM_019836.3) ENSMUST00000047860.1 ENSMUST00000047860.2 ENSMUST00000047860.3 ENSMUST00000047860.4 ENSMUST00000047860.5 ENSMUST00000047860.6 ENSMUST00000047860.7 ENSMUST00000047860.8 MNCb-4931 NM_019836 NOA1_MOUSE Q3T996 Q3U044 Q99JU4 Q9JJG9 uc008xwc.1 uc008xwc.2 uc008xwc.3 uc008xwc.4 Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP. Homodimer or multimer. Interacts with mitochondrial complex I, DAP3, MRPL12 and MRPS27. Mitochondrion inner membrane ; Peripheral membrane protein atrix side Expressed in tissues associated with high mitochondria content including testes, heart, liver, brain and thymus. Also expressed in various bone cell lines. At 10.5 dpc, weak but widespread expression. By 12.5 dpc prominently expressed in the liver and also detected in developing CNS and dorsal root ganglia. At 14.5 dpc, expression is intensified in bone. Mice display mid-gestation lethality associated with a severe developmental defect of the embryo and trophoblast. Primary embryonic fibroblasts isolated from mutant 9.5 dpc embryos show deficient mitochondrial synthesis and a global defect of oxidative phosphorylation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOA1 subfamily. nucleotide binding GTP binding mitochondrion mitochondrial inner membrane apoptotic process regulation of cell death membrane extrinsic component of mitochondrial inner membrane mitochondrial translation regulation of cellular respiration uc008xwc.1 uc008xwc.2 uc008xwc.3 uc008xwc.4 
ENSMUST00000047864.11 Eef2 ENSMUST00000047864.11 eukaryotic translation elongation factor 2 (from RefSeq NM_007907.2) EF2_MOUSE ENSMUST00000047864.1 ENSMUST00000047864.10 ENSMUST00000047864.2 ENSMUST00000047864.3 ENSMUST00000047864.4 ENSMUST00000047864.5 ENSMUST00000047864.6 ENSMUST00000047864.7 ENSMUST00000047864.8 ENSMUST00000047864.9 NM_007907 P58252 Q544E4 uc007gge.1 uc007gge.2 uc007gge.3 uc007gge.4 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Binds to 80S ribosomes (PubMed:34815424). Actively translating ribosomes show mutually exclusive binding of eIF5a (EIF5A or EIF5A2) and EEF2/eEF2 (By similarity). Interacts with SERBP1; interaction sequesters EEF2/eEF2 at the A-site of the ribosome, thereby blocking the interaction sites of the mRNA-tRNA complex, promoting ribosome stabilization and hibernation (PubMed:34815424). Interacts with HABP4; interaction takes place at the A-site of hibernating ribosomes and promotes ribosome stabilization (By similarity). Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9. Interacts with RBPMS2 (By similarity). Cytoplasm Nucleus Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C- terminal cleavage product. Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase (PubMed:34815424). Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C- terminal fragment (By similarity). Diphthamide is 2-[3-carboxyamido-3-(trimethyl- ammonio)propyl]histidine (By similarity). ISGylated. Proteolytically processed at two sites following phosphorylation by CSK. SUMOylated following phosphorylation by CSK, promotes proteolytic cleavage. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. nucleotide binding p53 binding hematopoietic progenitor cell differentiation response to ischemia skeletal muscle contraction RNA binding translation elongation factor activity GTPase activity protein binding GTP binding cytoplasm cytosol polysome plasma membrane translation translational elongation aging 5S rRNA binding glial cell proliferation aggresome protein kinase binding response to estradiol response to endoplasmic reticulum stress skeletal muscle cell differentiation response to drug response to hydrogen peroxide polysomal ribosome ribosome binding membrane raft synapse response to ethanol positive regulation of translation actin filament binding response to folic acid cellular response to brain-derived neurotrophic factor stimulus ribonucleoprotein complex positive regulation of cytoplasmic translation nucleus uc007gge.1 uc007gge.2 uc007gge.3 uc007gge.4 
ENSMUST00000047875.16 Eef2k ENSMUST00000047875.16 eukaryotic elongation factor-2 kinase, transcript variant 11 (from RefSeq NR_178189.1) EF2K_MOUSE ENSMUST00000047875.1 ENSMUST00000047875.10 ENSMUST00000047875.11 ENSMUST00000047875.12 ENSMUST00000047875.13 ENSMUST00000047875.14 ENSMUST00000047875.15 ENSMUST00000047875.2 ENSMUST00000047875.3 ENSMUST00000047875.4 ENSMUST00000047875.5 ENSMUST00000047875.6 ENSMUST00000047875.7 ENSMUST00000047875.8 ENSMUST00000047875.9 NR_178189 O08796 uc009jnb.1 uc009jnb.2 uc009jnb.3 uc009jnb.4 uc009jnb.5 Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation (PubMed:9144159, PubMed:34815424). Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive (PubMed:9144159, PubMed:34815424). In turn, the rate of protein synthesis is reduced (PubMed:9144159, PubMed:34815424). Reaction=[translation elongation factor 2] + ATP = [translation elongation factor 2]-phosphate + ADP + H(+); Xref=Rhea:RHEA:21436, Rhea:RHEA-COMP:11268, Rhea:RHEA-COMP:11269, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.20; Evidence=; Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent. Monomer or homodimer (Probable). Interacts with Calmodulin/CALM1; this interaction is strictly required for phosphorylation activity (By similarity). Ubiquitously expressed (PubMed:9144159). Particularly abundant in skeletal muscle and heart (PubMed:9144159). Autophosphorylated at multiple residues, Thr-347 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-397 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-77 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-358 or RPS6KA1 and RPS6KB1 at Ser-365 instead decrease EEF2K activity and promote protein synthesis (By similarity). Belongs to the protein kinase superfamily. Alpha-type protein kinase family. nucleotide binding response to ischemia protein serine/threonine kinase activity elongation factor-2 kinase activity calcium ion binding calmodulin binding ATP binding translational elongation protein phosphorylation translation factor activity, RNA binding postsynaptic density kinase activity phosphorylation transferase activity regulation of protein autophosphorylation cellular response to insulin stimulus negative regulation of apoptotic process dendritic spine positive regulation of endocytosis protein autophosphorylation positive regulation of synapse assembly positive regulation of dendritic spine morphogenesis cellular response to calcium ion cellular response to cAMP cellular response to anoxia cellular response to brain-derived neurotrophic factor stimulus response to prolactin uc009jnb.1 uc009jnb.2 uc009jnb.3 uc009jnb.4 uc009jnb.5 
ENSMUST00000047876.7 Gm10710 ENSMUST00000047876.7 Gm10710 (from geneSymbol) ENSMUST00000047876.1 ENSMUST00000047876.2 ENSMUST00000047876.3 ENSMUST00000047876.4 ENSMUST00000047876.5 ENSMUST00000047876.6 uc290gey.1 uc290gey.2 uc290gey.1 uc290gey.2 
ENSMUST00000047883.11 Tspan15 ENSMUST00000047883.11 tetraspanin 15 (from RefSeq NM_197996.2) C0H5X1 ENSMUST00000047883.1 ENSMUST00000047883.10 ENSMUST00000047883.2 ENSMUST00000047883.3 ENSMUST00000047883.4 ENSMUST00000047883.5 ENSMUST00000047883.6 ENSMUST00000047883.7 ENSMUST00000047883.8 ENSMUST00000047883.9 F7BWT7 NM_197996 Q3TA07 TSN15_MOUSE uc007fgv.1 uc007fgv.2 uc007fgv.3 Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:23035126, PubMed:26668317). Promotes ADAM10-mediated cleavage of CDH2 (PubMed:26668317). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Interacts with ADAM10; the interaction influences ADAM10 substrate specificity, endocytosis and turnover. Cell membrane ; Multi-pass membrane protein Late endosome membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=F7BWT7-1; Sequence=Displayed; Name=2; IsoId=F7BWT7-2; Sequence=VSP_042389; Palmitoylated. Belongs to the tetraspanin (TM4SF) family. Sequence=BAE42863.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; endosome plasma membrane integral component of plasma membrane cell surface membrane integral component of membrane enzyme binding late endosome membrane negative regulation of Notch signaling pathway protein maturation protein localization to plasma membrane tetraspanin-enriched microdomain uc007fgv.1 uc007fgv.2 uc007fgv.3 
ENSMUST00000047885.14 Nt5dc1 ENSMUST00000047885.14 5'-nucleotidase domain containing 1, transcript variant 1 (from RefSeq NM_176968.5) ENSMUST00000047885.1 ENSMUST00000047885.10 ENSMUST00000047885.11 ENSMUST00000047885.12 ENSMUST00000047885.13 ENSMUST00000047885.2 ENSMUST00000047885.3 ENSMUST00000047885.4 ENSMUST00000047885.5 ENSMUST00000047885.6 ENSMUST00000047885.7 ENSMUST00000047885.8 ENSMUST00000047885.9 NM_176968 NT5D1_MOUSE Nt5c2l1 Q3TAL3 Q3TPT8 Q3TTI3 Q3UL73 Q4G0D1 Q8C5P5 uc007euv.1 uc007euv.2 uc007euv.3 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C5P5-1; Sequence=Displayed; Name=2; IsoId=Q8C5P5-2; Sequence=VSP_019948; Name=3; IsoId=Q8C5P5-3; Sequence=VSP_019949, VSP_019950; Belongs to the 5'(3')-deoxyribonucleotidase family. cellular_component 5'-nucleotidase activity dephosphorylation hydrolase activity metal ion binding uc007euv.1 uc007euv.2 uc007euv.3 
ENSMUST00000047888.8 Mmp1b ENSMUST00000047888.8 matrix metallopeptidase 1b (interstitial collagenase) (from RefSeq NM_032007.3) ENSMUST00000047888.1 ENSMUST00000047888.2 ENSMUST00000047888.3 ENSMUST00000047888.4 ENSMUST00000047888.5 ENSMUST00000047888.6 ENSMUST00000047888.7 G5E8A9 G5E8A9_MOUSE Mmp1b NM_032007 uc009ocn.1 uc009ocn.2 uc009ocn.3 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AJ278461.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Can bind about 5 Ca(2+) ions per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. Belongs to the peptidase M10A family. metalloendopeptidase activity collagen trimer proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity extracellular matrix metal ion binding uc009ocn.1 uc009ocn.2 uc009ocn.3 
ENSMUST00000047889.13 Atp1b2 ENSMUST00000047889.13 ATPase, Na+/K+ transporting, beta 2 polypeptide (from RefSeq NM_013415.6) Atp1b2 ENSMUST00000047889.1 ENSMUST00000047889.10 ENSMUST00000047889.11 ENSMUST00000047889.12 ENSMUST00000047889.2 ENSMUST00000047889.3 ENSMUST00000047889.4 ENSMUST00000047889.5 ENSMUST00000047889.6 ENSMUST00000047889.7 ENSMUST00000047889.8 ENSMUST00000047889.9 NM_013415 Q3UR55 Q3UR55_MOUSE RP23-56I20.2-001 uc007jqo.1 uc007jqo.2 uc007jqo.3 Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth. This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Membrane ; Single- pass type II membrane protein Belongs to the X(+)/potassium ATPases subunit beta family. ATPase activator activity sodium:potassium-exchanging ATPase activity sodium:potassium-exchanging ATPase complex ion transport potassium ion transport sodium ion transport cellular sodium ion homeostasis establishment or maintenance of transmembrane electrochemical gradient membrane integral component of membrane cellular potassium ion homeostasis positive regulation of ATPase activity sodium ion export from cell protein stabilization ATPase binding membrane repolarization positive regulation of potassium ion transmembrane transporter activity positive regulation of sodium ion export from cell positive regulation of potassium ion import potassium ion import across plasma membrane uc007jqo.1 uc007jqo.2 uc007jqo.3 
ENSMUST00000047898.14 Kdm2a ENSMUST00000047898.14 Kdm2a (from geneSymbol) BC076576 ENSMUST00000047898.1 ENSMUST00000047898.10 ENSMUST00000047898.11 ENSMUST00000047898.12 ENSMUST00000047898.13 ENSMUST00000047898.2 ENSMUST00000047898.3 ENSMUST00000047898.4 ENSMUST00000047898.5 ENSMUST00000047898.6 ENSMUST00000047898.7 ENSMUST00000047898.8 ENSMUST00000047898.9 F6YRW4 F6YRW4_MOUSE Kdm2a uc008fzx.1 uc008fzx.2 uc008fzx.3 uc008fzx.4 DNA binding nucleus double-strand break repair via nonhomologous end joining zinc ion binding negative regulation of transcription by competitive promoter binding circadian regulation of gene expression regulation of circadian rhythm metal ion binding histone demethylase activity (H3-K36 specific) histone H3-K36 demethylation uc008fzx.1 uc008fzx.2 uc008fzx.3 uc008fzx.4 
ENSMUST00000047899.13 Mettl17 ENSMUST00000047899.13 methyltransferase like 17 (from RefSeq NM_001029990.2) B2RSP2 D14Ertd209e ENSMUST00000047899.1 ENSMUST00000047899.10 ENSMUST00000047899.11 ENSMUST00000047899.12 ENSMUST00000047899.2 ENSMUST00000047899.3 ENSMUST00000047899.4 ENSMUST00000047899.5 ENSMUST00000047899.6 ENSMUST00000047899.7 ENSMUST00000047899.8 ENSMUST00000047899.9 MET17_MOUSE Mettl17 NM_001029990 Q3U2U7 uc007tnh.1 uc007tnh.2 Probable S-adenosyl-L-methionine-dependent RNA methyltransferase required to stabilize the mitochondrial small ribosomal subunit (mt-SSU) (PubMed:31487196). Required for protein translation in mitochondria (PubMed:31487196). Interacts with mitochondrial small ribosomal subunit (mt-SSU) subunits MRPS15 and MRPS27. Mitochondrion matrix Belongs to the methyltransferase superfamily. Rsm22 family. nucleus nucleoplasm mitochondrion ribosome translation methyltransferase activity transferase activity methylation uc007tnh.1 uc007tnh.2 
ENSMUST00000047903.10 Colgalt1 ENSMUST00000047903.10 collagen beta(1-O)galactosyltransferase 1, transcript variant 1 (from RefSeq NM_146211.3) ENSMUST00000047903.1 ENSMUST00000047903.2 ENSMUST00000047903.3 ENSMUST00000047903.4 ENSMUST00000047903.5 ENSMUST00000047903.6 ENSMUST00000047903.7 ENSMUST00000047903.8 ENSMUST00000047903.9 GT251_MOUSE Glt25d1 NM_146211 Q3V3R5 Q6PGL1 Q8K297 uc009mee.1 uc009mee.2 uc009mee.3 uc009mee.4 Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix. Also involved in the biosynthesis of collagen type IV. Reaction=(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP; Xref=Rhea:RHEA:12637, Rhea:RHEA-COMP:12752, Rhea:RHEA- COMP:12753, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:133442, ChEBI:CHEBI:133443; EC=2.4.1.50; Evidence=; Endoplasmic reticulum lumen te=Colocalized with PLOD3 and mannose binding lectin. N-glycosylated. Belongs to the glycosyltransferase 25 family. endoplasmic reticulum endoplasmic reticulum lumen transferase activity transferase activity, transferring glycosyl groups procollagen galactosyltransferase activity positive regulation of collagen fibril organization uc009mee.1 uc009mee.2 uc009mee.3 uc009mee.4 
ENSMUST00000047904.4 Hoxd4 ENSMUST00000047904.4 homeobox D4 (from RefSeq NM_010469.2) A2ASN3 ENSMUST00000047904.1 ENSMUST00000047904.2 ENSMUST00000047904.3 HXD4_MOUSE Hox-4.2 Hoxd-4 NM_010469 P10628 P97451 Q3UXL6 uc008kef.1 uc008kef.2 uc008kef.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Forms a DNA-binding heterodimer with transcription factor PBX1. Nucleus. Belongs to the Antp homeobox family. Deformed subfamily. Sequence=AAA20072.1; Type=Erroneous initiation; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification cell junction activating transcription factor binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system morphogenesis stem cell differentiation uc008kef.1 uc008kef.2 uc008kef.3 
ENSMUST00000047906.10 Tiparp ENSMUST00000047906.10 TCDD-inducible poly(ADP-ribose) polymerase (from RefSeq NM_178892.5) ENSMUST00000047906.1 ENSMUST00000047906.2 ENSMUST00000047906.3 ENSMUST00000047906.4 ENSMUST00000047906.5 ENSMUST00000047906.6 ENSMUST00000047906.7 ENSMUST00000047906.8 ENSMUST00000047906.9 NM_178892 PARPT_MOUSE Q3UD50 Q8C032 Q8C1B2 Tiparp uc008pkr.1 uc008pkr.2 uc008pkr.3 ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (By similarity). Acts as a negative regulator of AHR by mediating mono-ADP- ribosylation of AHR, leading to inhibit transcription activator activity of AHR (Probable). Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA- COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=; Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence=; Reaction=L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP- D-ribosyl)-L-cysteinyl-[protein]; Xref=Rhea:RHEA:56612, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:14624, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29950, ChEBI:CHEBI:57540, ChEBI:CHEBI:140607; Evidence=; Interacts with AHR. Nucleus Ubiquitously expressed. By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is a by-product of industrial processes and an important environmental contaminant (PubMed:11716501, PubMed:12147270). This induction is concentration and time-dependent and is mediated through an aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocation (Arnt) signal transduction (PubMed:11716501, PubMed:12147270). Superinduced by cycloheximide and by inhibitors of the 26S proteasome (PubMed:11716501, PubMed:12147270). Auto-mono-ADP-ribosylated. Belongs to the ARTD/PARP family. vasculogenesis kidney development NAD+ ADP-ribosyltransferase activity nucleus protein ADP-ribosylation nitrogen compound metabolic process androgen metabolic process estrogen metabolic process female gonad development post-embryonic development negative regulation of gene expression transferase activity transferase activity, transferring glycosyl groups hemopoiesis enhancer binding positive regulation of protein catabolic process metal ion binding platelet-derived growth factor receptor signaling pathway skeletal system morphogenesis smooth muscle tissue development palate development face morphogenesis protein auto-ADP-ribosylation cellular response to organic cyclic compound response to 2,3,7,8-tetrachlorodibenzodioxine protein ADP-ribosylase activity uc008pkr.1 uc008pkr.2 uc008pkr.3 
ENSMUST00000047910.15 Metap2 ENSMUST00000047910.15 Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (from UniProt Q58E65) AK165611 ENSMUST00000047910.1 ENSMUST00000047910.10 ENSMUST00000047910.11 ENSMUST00000047910.12 ENSMUST00000047910.13 ENSMUST00000047910.14 ENSMUST00000047910.2 ENSMUST00000047910.3 ENSMUST00000047910.4 ENSMUST00000047910.5 ENSMUST00000047910.6 ENSMUST00000047910.7 ENSMUST00000047910.8 ENSMUST00000047910.9 METAP2 Metap2 Q58E65 Q58E65_MOUSE uc287uez.1 uc287uez.2 Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. Reaction=Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; EC=3.4.11.18; Evidence= Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site. ; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3. Cytoplasm Note=About 30% of expressed METAP2 associates with polysomes. Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding. Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. aminopeptidase activity cytoplasm cytosol plasma membrane proteolysis peptidase activity metalloexopeptidase activity protein processing hydrolase activity peptidyl-methionine modification N-terminal protein amino acid modification metal ion binding metalloaminopeptidase activity protein initiator methionine removal uc287uez.1 uc287uez.2 
ENSMUST00000047922.3 Ttc22 ENSMUST00000047922.3 tetratricopeptide repeat domain 22 (from RefSeq NM_177667.5) ENSMUST00000047922.1 ENSMUST00000047922.2 NM_177667 Q8C159 TTC22_MOUSE uc008tyn.1 uc008tyn.2 uc008tyn.3 molecular_function cellular_component biological_process uc008tyn.1 uc008tyn.2 uc008tyn.3 
ENSMUST00000047923.12 Sec24d ENSMUST00000047923.12 SEC24 homolog D, COPII coat complex component (from RefSeq NM_027135.2) ENSMUST00000047923.1 ENSMUST00000047923.10 ENSMUST00000047923.11 ENSMUST00000047923.2 ENSMUST00000047923.3 ENSMUST00000047923.4 ENSMUST00000047923.5 ENSMUST00000047923.6 ENSMUST00000047923.7 ENSMUST00000047923.8 ENSMUST00000047923.9 NM_027135 Q6NXL1 Q6NXL1_MOUSE Sec24d uc008rfh.1 uc008rfh.2 uc008rfh.3 Cytoplasm, cytosol Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the SEC23/SEC24 family. SEC24 subfamily. Golgi membrane SNARE binding in utero embryonic development intracellular protein transport ER to Golgi vesicle-mediated transport zinc ion binding protein transport COPII vesicle coat cargo loading into COPII-coated vesicle uc008rfh.1 uc008rfh.2 uc008rfh.3 
ENSMUST00000047929.13 Acsm1 ENSMUST00000047929.13 acyl-CoA synthetase medium-chain family member 1, transcript variant 1 (from RefSeq NM_054094.6) ACSM1_MOUSE Bucs1 ENSMUST00000047929.1 ENSMUST00000047929.10 ENSMUST00000047929.11 ENSMUST00000047929.12 ENSMUST00000047929.2 ENSMUST00000047929.3 ENSMUST00000047929.4 ENSMUST00000047929.5 ENSMUST00000047929.6 ENSMUST00000047929.7 ENSMUST00000047929.8 ENSMUST00000047929.9 Lae Macs1 NM_054094 Q3UED4 Q91VA0 uc009jlm.1 uc009jlm.2 uc009jlm.3 uc009jlm.4 Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11470804, PubMed:12709059). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate- containing xenobiotics, e.g. benzoate (PubMed:11470804, PubMed:12709059). Also catalyzes the activation of lipoate to lipoyl- nucleoside monophosphate (By similarity). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)- lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By similarity). Reaction=a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:48340, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:59558, ChEBI:CHEBI:90546, ChEBI:CHEBI:456215; EC=6.2.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48341; Evidence=; Reaction=ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate; Xref=Rhea:RHEA:10132, ChEBI:CHEBI:16150, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57369, ChEBI:CHEBI:456215; EC=6.2.1.25; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10133; Evidence=; Reaction=(R)-lipoate + GTP + H(+) = (R)-lipoyl-GMP + diphosphate; Xref=Rhea:RHEA:46700, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:83088, ChEBI:CHEBI:86460; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46701; Evidence=; Reaction=ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA; Xref=Rhea:RHEA:33631, ChEBI:CHEBI:25646, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:456215; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33632; Evidence=; Reaction=ATP + CoA + decanoate = AMP + decanoyl-CoA + diphosphate; Xref=Rhea:RHEA:33627, ChEBI:CHEBI:27689, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430, ChEBI:CHEBI:456215; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33628; Evidence=; Reaction=ATP + CoA + dodecanoate = AMP + diphosphate + dodecanoyl-CoA; Xref=Rhea:RHEA:33623, ChEBI:CHEBI:18262, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:456215; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33624; Evidence=; Reaction=ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA; Xref=Rhea:RHEA:33619, ChEBI:CHEBI:30616, ChEBI:CHEBI:30807, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33620; Evidence=; Reaction=ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA; Xref=Rhea:RHEA:43740, ChEBI:CHEBI:17120, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:62620, ChEBI:CHEBI:456215; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43741; Evidence=; Reaction=ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate; Xref=Rhea:RHEA:46172, ChEBI:CHEBI:17968, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46173; Evidence=; Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl- CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30752; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Kinetic parameters: KM=1.58 mM for hexanoate ; KM=0.46 mM for octanoate ; Monomer. Mitochondrion matrix Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VA0-1; Sequence=Displayed; Name=2; IsoId=Q91VA0-2; Sequence=VSP_028392; Highly expressed in liver and kidney. Belongs to the ATP-dependent AMP-binding enzyme family. nucleotide binding catalytic activity acyl-CoA ligase activity fatty-acyl-CoA synthase activity ATP binding GTP binding mitochondrion mitochondrial matrix lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process acyl-CoA metabolic process fatty acid ligase activity ligase activity benzoate-CoA ligase activity metal ion binding butyrate-CoA ligase activity decanoate--CoA ligase activity uc009jlm.1 uc009jlm.2 uc009jlm.3 uc009jlm.4 
ENSMUST00000047935.8 Tspyl4 ENSMUST00000047935.8 TSPY-like 4 (from RefSeq NM_030203.2) D10Bwg0791e ENSMUST00000047935.1 ENSMUST00000047935.2 ENSMUST00000047935.3 ENSMUST00000047935.4 ENSMUST00000047935.5 ENSMUST00000047935.6 ENSMUST00000047935.7 NM_030203 Q8VD63 TSYL4_MOUSE uc007euu.1 uc007euu.2 uc007euu.3 Belongs to the nucleosome assembly protein (NAP) family. molecular_function cellular_component nucleus nucleosome assembly biological_process uc007euu.1 uc007euu.2 uc007euu.3 
ENSMUST00000047936.13 Cmklr1 ENSMUST00000047936.13 chemerin chemokine-like receptor 1, transcript variant 2 (from RefSeq NM_008153.3) Cmklr1 ENSMUST00000047936.1 ENSMUST00000047936.10 ENSMUST00000047936.11 ENSMUST00000047936.12 ENSMUST00000047936.2 ENSMUST00000047936.3 ENSMUST00000047936.4 ENSMUST00000047936.5 ENSMUST00000047936.6 ENSMUST00000047936.7 ENSMUST00000047936.8 ENSMUST00000047936.9 NM_008153 Q497D3 Q497D3_MOUSE uc012ebo.1 uc012ebo.2 uc012ebo.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Belongs to the chemokine-like receptor (CMKLR) family. G-protein coupled receptor activity plasma membrane chemotaxis signal transduction G-protein coupled receptor signaling pathway positive regulation of macrophage chemotaxis membrane integral component of membrane negative regulation of NF-kappaB transcription factor activity regulation of calcium-mediated signaling uc012ebo.1 uc012ebo.2 uc012ebo.3 
ENSMUST00000047945.2 Samt3 ENSMUST00000047945.2 spermatogenesis associated multipass transmembrane protein 3 (from RefSeq NM_028554.3) 1700072E05Rik A2ARK7 A2ARK7_MOUSE ENSMUST00000047945.1 NM_028554 Samt3 uc009tsc.1 uc009tsc.2 Cell junction, tight junction Belongs to the claudin family. molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc009tsc.1 uc009tsc.2 
ENSMUST00000047950.6 Zfp292 ENSMUST00000047950.6 zinc finger protein 292 (from RefSeq NM_013889.2) B1B0E1 B1B0E2 ENSMUST00000047950.1 ENSMUST00000047950.2 ENSMUST00000047950.3 ENSMUST00000047950.4 ENSMUST00000047950.5 NM_013889 Q8BQX3 Q8BS87 Q8CGI6 Q922D3 Q9Z2U2 ZN292_MOUSE Zfp15 Zfp292 uc008sgn.1 uc008sgn.2 uc008sgn.3 uc008sgn.4 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q9Z2U2-1; Sequence=Displayed; Name=2 ; IsoId=Q9Z2U2-2; Sequence=VSP_053207; Expressed in postnatal day 1 (P1) pituitary. Also detected in presomatotrophic cell line GHFT1-5. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAD01625.1; Type=Erroneous initiation; Evidence=; Sequence=AAH36997.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC28892.1; Type=Erroneous initiation; Evidence=; Sequence=BAC32648.1; Type=Erroneous initiation; Evidence=; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus positive regulation of transcription from RNA polymerase II promoter metal ion binding uc008sgn.1 uc008sgn.2 uc008sgn.3 uc008sgn.4 
ENSMUST00000047951.9 Fbxo2 ENSMUST00000047951.9 F-box protein 2, transcript variant 4 (from RefSeq NR_185083.1) ENSMUST00000047951.1 ENSMUST00000047951.2 ENSMUST00000047951.3 ENSMUST00000047951.4 ENSMUST00000047951.5 ENSMUST00000047951.6 ENSMUST00000047951.7 ENSMUST00000047951.8 FBX2_MOUSE Fbs1 Fbx2 NR_185083 Q80UW2 Q8R0D2 uc008vuk.1 uc008vuk.2 uc008vuk.3 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type. Protein modification; protein ubiquitination. Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex. Q80UW2; P61823: RNASE1; Xeno; NbExp=2; IntAct=EBI-2314714, EBI-908364; Q80UW2; P63208-1: SKP1; Xeno; NbExp=4; IntAct=EBI-2314714, EBI-307497; Cytoplasm. Microsome membrane; Peripheral membrane protein; Cytoplasmic side. Detected in brain and cochlea, in epithelial support cells and hair cells of the organ of Corti (at protein level). No visible phenotype at birth. Mice are viable and fertile, but after two to four months, gradual hearing loss sets in, due to degeneration of epithelial support cells and hair cells of the organ of Corti and spiral ganglion neurodegeneration. beta-amyloid binding protein binding cytoplasm endoplasmic reticulum cytosol ubiquitin-dependent protein catabolic process glycoprotein catabolic process negative regulation of cell proliferation membrane protein ubiquitination SCF ubiquitin ligase complex carbohydrate binding ER-associated ubiquitin-dependent protein catabolic process organelle membrane SCF-dependent proteasomal ubiquitin-dependent protein catabolic process regulation of protein ubiquitination dendritic spine intracellular membrane-bounded organelle ubiquitin protein ligase activity uc008vuk.1 uc008vuk.2 uc008vuk.3 
ENSMUST00000047973.4 Dhcr24 ENSMUST00000047973.4 24-dehydrocholesterol reductase (from RefSeq NM_053272.3) DHC24_MOUSE ENSMUST00000047973.1 ENSMUST00000047973.2 ENSMUST00000047973.3 Kiaa0018 NM_053272 Q6ZQK9 Q8VCH6 Q91ZD0 Q9CU63 uc008tyl.1 uc008tyl.2 Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:26114596). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis (By similarity). Reaction=5alpha-cholest-8-en-3beta-ol + NADP(+) = H(+) + NADPH + zymosterol; Xref=Rhea:RHEA:36399, ChEBI:CHEBI:15378, ChEBI:CHEBI:16608, ChEBI:CHEBI:18252, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.72; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:36401; Evidence=; Reaction=cholesterol + NADP(+) = desmosterol + H(+) + NADPH; Xref=Rhea:RHEA:36391, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:17737, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.72; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36392; Evidence=; Reaction=H(+) + lanosterol + NADPH = 24,25-dihydrolanosterol + NADP(+); Xref=Rhea:RHEA:33919, ChEBI:CHEBI:15378, ChEBI:CHEBI:16521, ChEBI:CHEBI:28113, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33920; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Steroid biosynthesis; cholesterol biosynthesis. Endoplasmic reticulum membrane ; Single-pass membrane protein Golgi apparatus membrane ; Single-pass membrane protein Belongs to the FAD-binding oxidoreductase/transferase type 4 family. Sequence=BAC97846.1; Type=Erroneous initiation; Evidence=; Golgi membrane delta24(24-1) sterol reductase activity nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol cytoskeleton lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process response to oxidative stress Ras protein signal transduction protein localization steroid metabolic process cholesterol metabolic process negative regulation of cell proliferation response to hormone tissue development membrane integral component of membrane sterol metabolic process sterol biosynthetic process oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor enzyme binding male genitalia development plasminogen activation peptide antigen binding amyloid precursor protein catabolic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process skin development delta24-sterol reductase activity flavin adenine dinucleotide binding oxidation-reduction process membrane organization FAD binding uc008tyl.1 uc008tyl.2 
ENSMUST00000047978.9 Rabif ENSMUST00000047978.9 RAB interacting factor (from RefSeq NM_145510.2) ENSMUST00000047978.1 ENSMUST00000047978.2 ENSMUST00000047978.3 ENSMUST00000047978.4 ENSMUST00000047978.5 ENSMUST00000047978.6 ENSMUST00000047978.7 ENSMUST00000047978.8 MSS4_MOUSE NM_145510 Q3U2X4 Q91X96 Rabif uc007csc.1 uc007csc.2 uc007csc.3 uc007csc.4 Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1, RAB3A and RAB10, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport (By similarity). Interacts with RAB8A. Belongs to the DSS4/MSS4 family. guanyl-nucleotide exchange factor activity cytosol post-Golgi vesicle-mediated transport small GTPase mediated signal transduction zinc ion binding protein transport membrane metal ion binding uc007csc.1 uc007csc.2 uc007csc.3 uc007csc.4 
ENSMUST00000047997.8 Sp6 ENSMUST00000047997.8 trans-acting transcription factor 6, transcript variant 1 (from RefSeq NM_031183.3) ENSMUST00000047997.1 ENSMUST00000047997.2 ENSMUST00000047997.3 ENSMUST00000047997.4 ENSMUST00000047997.5 ENSMUST00000047997.6 ENSMUST00000047997.7 Epfn Klf14 NM_031183 Q6VM22 Q9ESX2 SP6_MOUSE uc007ldh.1 uc007ldh.2 uc007ldh.3 uc007ldh.4 Promotes cell proliferation (PubMed:14551215). Plays a role in tooth germ growth (PubMed:30426815). Plays a role in the control of enamel mineralization. Binds the AMBN promoter (By similarity). Nucleus Ubiquitous. Preferentially expressed by proliferating epithelial cells of teeth, hair follicles and limbs. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Develops fewer, smaller, incisors at 3 months of age in a transcription factor ASCL5/AmeloD knockout background (PubMed:30426815). Epithelial cell invasion is inhibited and CDH1/E- cadherin ectopically expressed in dental epithelial cells at 3 months of age, in an ASCL5 knockout background (PubMed:30426815). Belongs to the Sp1 C2H2-type zinc-finger protein family. RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleic acid binding DNA binding nucleus cytosol regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter regulation of odontogenesis metal ion binding uc007ldh.1 uc007ldh.2 uc007ldh.3 uc007ldh.4 
ENSMUST00000048001.8 Dmgdh ENSMUST00000048001.8 dimethylglycine dehydrogenase precursor (from RefSeq NM_028772.3) B1B1D0 ENSMUST00000048001.1 ENSMUST00000048001.2 ENSMUST00000048001.3 ENSMUST00000048001.4 ENSMUST00000048001.5 ENSMUST00000048001.6 ENSMUST00000048001.7 M2GD_MOUSE NM_028772 Q8R1S7 Q9DBT9 uc007rll.1 uc007rll.2 uc007rll.3 This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. [provided by RefSeq, Jul 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK004755.1, BC089599.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro. Reaction=(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N- dimethylglycine + oxidized [electron-transfer flavoprotein] = (6R)- 5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron- transfer flavoprotein] + sarcosine; Xref=Rhea:RHEA:52856, Rhea:RHEA- COMP:10685, Rhea:RHEA-COMP:10686, Rhea:RHEA-COMP:13257, Rhea:RHEA- COMP:14738, ChEBI:CHEBI:15378, ChEBI:CHEBI:57433, ChEBI:CHEBI:57692, ChEBI:CHEBI:58251, ChEBI:CHEBI:58307, ChEBI:CHEBI:136572, ChEBI:CHEBI:141005; EC=1.5.8.4; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD covalently per monomer. ; Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 2/2. Mitochondrion Belongs to the GcvT family. folic acid binding cytoplasm mitochondrion mitochondrial matrix amino-acid betaine catabolic process oxidoreductase activity tetrahydrofolate interconversion choline catabolic process dimethylglycine dehydrogenase activity flavin adenine dinucleotide binding oxidation-reduction process uc007rll.1 uc007rll.2 uc007rll.3 
ENSMUST00000048002.7 B4galnt4 ENSMUST00000048002.7 beta-1,4-N-acetyl-galactosaminyl transferase 4 (from RefSeq NM_177897.4) B4GN4_MOUSE ENSMUST00000048002.1 ENSMUST00000048002.2 ENSMUST00000048002.3 ENSMUST00000048002.4 ENSMUST00000048002.5 ENSMUST00000048002.6 NM_177897 Q766D5 Q8CHV2 uc009kje.1 uc009kje.2 uc009kje.3 Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Reaction=an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl- alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N- acetyl-beta-D-glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:20493, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:61631, ChEBI:CHEBI:67138, ChEBI:CHEBI:138027; EC=2.4.1.244; Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q766D5-1; Sequence=Displayed; Name=2; IsoId=Q766D5-2; Sequence=VSP_020917; Belongs to the chondroitin N- acetylgalactosaminyltransferase family. Name=Functional Glycomics Gateway - GTase; Note=Beta1,4- N-acetylgalactosaminyltransferase IV; URL="http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=gt_mou_508"; Golgi apparatus acetylgalactosaminyltransferase activity membrane integral component of membrane transferase activity Golgi cisterna membrane N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity uc009kje.1 uc009kje.2 uc009kje.3 
ENSMUST00000048010.9 Dse ENSMUST00000048010.9 dermatan sulfate epimerase (from RefSeq NM_172508.3) DSE_MOUSE ENSMUST00000048010.1 ENSMUST00000048010.2 ENSMUST00000048010.3 ENSMUST00000048010.4 ENSMUST00000048010.5 ENSMUST00000048010.6 ENSMUST00000048010.7 ENSMUST00000048010.8 NM_172508 Q3U620 Q8BLI4 Sart2 uc007eus.1 uc007eus.2 uc007eus.3 Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate. Reaction=chondroitin 4'-sulfate = dermatan 4'-sulfate; Xref=Rhea:RHEA:21084, Rhea:RHEA-COMP:9829, Rhea:RHEA-COMP:9965, ChEBI:CHEBI:58422, ChEBI:CHEBI:58465; EC=5.1.3.19; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Also has weak activity in the presence of Mg(2+) or Ca(2+) ions. ; Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Microsome membrane ; Multi-pass membrane protein N-glycosylated. Glycosylation is important for enzymatic activity. Belongs to the dermatan-sulfate isomerase family. Sequence=BAE31905.1; Type=Erroneous initiation; Evidence=; nucleoplasm endoplasmic reticulum Golgi apparatus cytosol heparan sulfate proteoglycan biosynthetic process membrane integral component of membrane isomerase activity chondroitin sulfate biosynthetic process dermatan sulfate biosynthetic process chondroitin-glucuronate 5-epimerase activity uc007eus.1 uc007eus.2 uc007eus.3 
ENSMUST00000048016.3 Fut11 ENSMUST00000048016.3 fucosyltransferase 11 (from RefSeq NM_028428.2) ENSMUST00000048016.1 ENSMUST00000048016.2 FUT11_MOUSE NM_028428 Q8BHC9 Q9CXS9 uc007skk.1 uc007skk.2 uc007skk.3 Has fucosyltransferase activity toward biantennary N-glycan acceptors. Does not fucosylate GlcNAc residue within type 2 lactosamine unit. Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Widely expressed. Expressed at slightly higher level in heart, kidney and lung. Belongs to the glycosyltransferase 10 family. Name=Functional Glycomics Gateway - GTase; Note=Fucosyltransferase 11; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_618"; Golgi membrane Golgi apparatus protein glycosylation fucosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups Golgi cisterna membrane fucosylation alpha-(1->3)-fucosyltransferase activity uc007skk.1 uc007skk.2 uc007skk.3 
ENSMUST00000048026.10 Hoxa11 ENSMUST00000048026.10 homeobox A11 (from RefSeq NM_010450.4) ENSMUST00000048026.1 ENSMUST00000048026.2 ENSMUST00000048026.3 ENSMUST00000048026.4 ENSMUST00000048026.5 ENSMUST00000048026.6 ENSMUST00000048026.7 ENSMUST00000048026.8 ENSMUST00000048026.9 HXA11_MOUSE Hox-1.9 Hoxa-11 NM_010450 P31311 Q3V026 uc009byn.1 uc009byn.2 uc009byn.3 uc009byn.4 This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important in the development of the skeleton, limbs, and urogenital tract. Expression of this gene may be regulated by overlapping transcription from an adjacent locus on the opposite strand (GeneID: 15397). [provided by RefSeq, Mar 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133481.1, BC052232.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. P31311; O88513: Gmnn; NbExp=2; IntAct=EBI-445941, EBI-445922; Nucleus. Belongs to the Abd-B homeobox family. skeletal system development metanephros development branching involved in ureteric bud morphogenesis organ induction DNA binding protein binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated multicellular organism development spermatogenesis single fertilization mesodermal cell fate specification male gonad development anterior/posterior pattern specification dorsal/ventral pattern formation proximal/distal pattern formation regulation of gene expression positive regulation of cell development embryonic limb morphogenesis regulation of chondrocyte differentiation positive regulation of chondrocyte differentiation macromolecular complex protein-DNA complex embryonic forelimb morphogenesis embryonic digit morphogenesis sequence-specific DNA binding positive regulation of transcription, DNA-templated developmental growth uterus development embryonic skeletal joint morphogenesis bone development cartilage development involved in endochondral bone morphogenesis uc009byn.1 uc009byn.2 uc009byn.3 uc009byn.4 
ENSMUST00000048028.15 Stag3 ENSMUST00000048028.15 STAG3 cohesin complex component (from RefSeq NM_016964.2) B2RSV0 ENSMUST00000048028.1 ENSMUST00000048028.10 ENSMUST00000048028.11 ENSMUST00000048028.12 ENSMUST00000048028.13 ENSMUST00000048028.14 ENSMUST00000048028.2 ENSMUST00000048028.3 ENSMUST00000048028.4 ENSMUST00000048028.5 ENSMUST00000048028.6 ENSMUST00000048028.7 ENSMUST00000048028.8 ENSMUST00000048028.9 NM_016964 O70576 STAG3_MOUSE uc009afn.1 uc009afn.2 uc009afn.3 uc009afn.4 Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Component of the meiosis-specific cohesin complex, which also contains the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer. Such complex likely contains RAD21, or the meiosis-specific related protein REC8 (By similarity). Interacts with CCDC79/TERB1; recruiting cohesin to telomeres to develop structural rigidity. Nucleus romosome Chromosome, centromere Note=Associates with chromatin. In prophase I stage of meiosis, it is found along the axial elements of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. It however remains chromatin associated at the centromeres up to metaphase I. During anaphase I, it probably dissociates from centromeres, allowing chromosomes segregation. Testis specific. Phosphorylated. Deficient mice are sterile and their fetal oocytes are arrested at early prophase I leading to oocyte depletion at 1 week of age. Belongs to the SCC3 family. chromosome, centromeric region chromatin condensed nuclear chromosome synaptonemal complex lateral element transverse filament male germ cell nucleus chromatin binding protein binding nucleus nucleoplasm chromosome cell cycle chromosome segregation sister chromatid cohesion male meiosis sister chromatid cohesion female meiosis sister chromatid cohesion synapsis cohesin complex meiotic cohesin complex protein localization to chromosome nuclear meiotic cohesin complex meiotic cell cycle uc009afn.1 uc009afn.2 uc009afn.3 uc009afn.4 
ENSMUST00000048032.5 Kap ENSMUST00000048032.5 kidney androgen regulated protein (from RefSeq NM_010594.2) ENSMUST00000048032.1 ENSMUST00000048032.2 ENSMUST00000048032.3 ENSMUST00000048032.4 Kap NM_010594 Q3UQF0 Q3UQF0_MOUSE uc009ekd.1 uc009ekd.2 uc009ekd.3 uc009ekd.1 uc009ekd.2 uc009ekd.3 
ENSMUST00000048043.12 Coro2b ENSMUST00000048043.12 coronin, actin binding protein, 2B (from RefSeq NM_175484.3) COR2B_MOUSE ENSMUST00000048043.1 ENSMUST00000048043.10 ENSMUST00000048043.11 ENSMUST00000048043.2 ENSMUST00000048043.3 ENSMUST00000048043.4 ENSMUST00000048043.5 ENSMUST00000048043.6 ENSMUST00000048043.7 ENSMUST00000048043.8 ENSMUST00000048043.9 NM_175484 Q6P5U9 Q8BH44 uc009qaj.1 uc009qaj.2 May play a role in the reorganization of neuronal actin structure. Binds to F-actin and to vinculin. Cytoplasm, cytoskeleton Belongs to the WD repeat coronin family. Sequence=AAH62649.1; Type=Erroneous initiation; Evidence=; Sequence=BAC33080.1; Type=Erroneous initiation; Evidence=; Sequence=BAC39865.1; Type=Erroneous initiation; Evidence=; stress fiber regulation of glomerular filtration actin binding cytoplasm cytoskeleton focal adhesion negative regulation of cell-substrate adhesion membrane vinculin binding actin cytoskeleton organization regulation of actin cytoskeleton organization focal adhesion assembly actin filament binding negative regulation of stress fiber assembly regulation of cellular response to stress negative regulation of establishment of protein localization positive regulation of establishment of protein localization talin binding uc009qaj.1 uc009qaj.2 
ENSMUST00000048044.12 Trub2 ENSMUST00000048044.12 TruB pseudouridine (psi) synthase family member 2, transcript variant 1 (from RefSeq NM_145520.5) ENSMUST00000048044.1 ENSMUST00000048044.10 ENSMUST00000048044.11 ENSMUST00000048044.2 ENSMUST00000048044.3 ENSMUST00000048044.4 ENSMUST00000048044.5 ENSMUST00000048044.6 ENSMUST00000048044.7 ENSMUST00000048044.8 ENSMUST00000048044.9 NM_145520 Q8BTK3 Q91WG3 TRUB2_MOUSE Trub2 uc008jaa.1 uc008jaa.2 uc008jaa.3 uc008jaa.4 uc008jaa.5 Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt- mRNAs) such as COXI and COXIII mt-mRNAs. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. Reaction=a uridine in mRNA = a pseudouridine in mRNA; Xref=Rhea:RHEA:56644, Rhea:RHEA-COMP:14658, Rhea:RHEA-COMP:14659, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Reaction=uridine(55) in tRNA = pseudouridine(55) in tRNA; Xref=Rhea:RHEA:42532, Rhea:RHEA-COMP:10101, Rhea:RHEA-COMP:10102, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.25; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42533; Evidence=; Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Mitochondrion matrix Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. Belongs to the pseudouridine synthase TruB family. pseudouridine synthesis RNA binding mitochondrion mitochondrial matrix cytosol RNA processing mRNA processing tRNA processing RNA modification pseudouridine synthase activity isomerase activity positive regulation of mitochondrial translation uc008jaa.1 uc008jaa.2 uc008jaa.3 uc008jaa.4 uc008jaa.5 
ENSMUST00000048050.9 Tmem45b ENSMUST00000048050.9 transmembrane protein 45b (from RefSeq NM_144936.1) ENSMUST00000048050.1 ENSMUST00000048050.2 ENSMUST00000048050.3 ENSMUST00000048050.4 ENSMUST00000048050.5 ENSMUST00000048050.6 ENSMUST00000048050.7 ENSMUST00000048050.8 NM_144936 Q3UNB2 Q8VCZ2 TM45B_MOUSE uc009ort.1 uc009ort.2 uc009ort.3 Plays a role in innate immunity. Endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Belongs to the TMEM45 family. molecular_function cellular_component biological_process membrane integral component of membrane uc009ort.1 uc009ort.2 uc009ort.3 
ENSMUST00000048052.7 Calhm4 ENSMUST00000048052.7 calcium homeostasis modulator family member 4 (from RefSeq NM_001081165.1) CAHM4_MOUSE ENSMUST00000048052.1 ENSMUST00000048052.2 ENSMUST00000048052.3 ENSMUST00000048052.4 ENSMUST00000048052.5 ENSMUST00000048052.6 Fam26d NM_001081165 Q8CE93 uc007eup.1 uc007eup.2 uc007eup.3 Pore-forming subunit of a voltage-gated ion channel. Membrane ; Multi-pass membrane protein Belongs to the CALHM family. Sequence=BAC26107.1; Type=Erroneous initiation; Evidence=; integral component of plasma membrane ion transport membrane integral component of membrane uc007eup.1 uc007eup.2 uc007eup.3 
ENSMUST00000048054.14 Chtf18 ENSMUST00000048054.14 CTF18, chromosome transmission fidelity factor 18 (from RefSeq NM_145409.2) A0A0R4J0I4 A0A0R4J0I4_MOUSE Chtf18 ENSMUST00000048054.1 ENSMUST00000048054.10 ENSMUST00000048054.11 ENSMUST00000048054.12 ENSMUST00000048054.13 ENSMUST00000048054.2 ENSMUST00000048054.3 ENSMUST00000048054.4 ENSMUST00000048054.5 ENSMUST00000048054.6 ENSMUST00000048054.7 ENSMUST00000048054.8 ENSMUST00000048054.9 NM_145409 uc008bbk.1 uc008bbk.2 uc008bbk.3 uc008bbk.4 DNA clamp loader activity ATP binding nucleoplasm cytosol single-stranded DNA-dependent ATP-dependent DNA helicase activity Ctf18 RFC-like complex DNA duplex unwinding positive regulation of DNA-directed DNA polymerase activity uc008bbk.1 uc008bbk.2 uc008bbk.3 uc008bbk.4 
ENSMUST00000048061.13 1700031F05Rik ENSMUST00000048061.13 RIKEN cDNA 1700031F05 gene (from RefSeq NM_028496.1) 1700031F05Rik B1AX30 B1AX30_MOUSE ENSMUST00000048061.1 ENSMUST00000048061.10 ENSMUST00000048061.11 ENSMUST00000048061.12 ENSMUST00000048061.2 ENSMUST00000048061.3 ENSMUST00000048061.4 ENSMUST00000048061.5 ENSMUST00000048061.6 ENSMUST00000048061.7 ENSMUST00000048061.8 ENSMUST00000048061.9 NM_028496 uc009tzb.1 uc009tzb.2 uc009tzb.3 molecular_function cellular_component biological_process uc009tzb.1 uc009tzb.2 uc009tzb.3 
ENSMUST00000048065.6 Trem3 ENSMUST00000048065.6 triggering receptor expressed on myeloid cells 3 (from RefSeq NM_021407.3) ENSMUST00000048065.1 ENSMUST00000048065.2 ENSMUST00000048065.3 ENSMUST00000048065.4 ENSMUST00000048065.5 NM_021407 Q9JKE1 TREM3_MOUSE Trem3 uc008cwy.1 uc008cwy.2 uc008cwy.3 uc008cwy.4 The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and is thought to function as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein has been reported to associate with the adaptor protein Dap-12 to form a receptor signaling complex that activates myeloid cells. [provided by RefSeq, Jan 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK079407.1, AF241220.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN00849388 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## Forms a receptor signaling complex with TYROBP/DAP12 which mediates activation of macrophages as part of the innate immune response. Interacts with TYROBP/DAP12. Cell membrane ; Single-pass type I membrane protein Expressed in macrophages and in T-cells. Induced by lipopolysaccharide (LPS). Interferon gamma (IFNG) decreases expression. cytokine secretion involved in immune response protein binding plasma membrane membrane integral component of membrane cell migration neutrophil chemotaxis cytokine metabolic process positive regulation of innate immune response chemokine metabolic process neutrophil mediated killing of gram-negative bacterium neutrophil extravasation lipopolysaccharide binding peptidoglycan binding lipoteichoic acid binding uc008cwy.1 uc008cwy.2 uc008cwy.3 uc008cwy.4 
ENSMUST00000048068.15 Arrdc4 ENSMUST00000048068.15 arrestin domain containing 4, transcript variant 1 (from RefSeq NM_001042592.2) A0A0B4J1F4 ARRD4_MOUSE Arrdc4 ENSMUST00000048068.1 ENSMUST00000048068.10 ENSMUST00000048068.11 ENSMUST00000048068.12 ENSMUST00000048068.13 ENSMUST00000048068.14 ENSMUST00000048068.2 ENSMUST00000048068.3 ENSMUST00000048068.4 ENSMUST00000048068.5 ENSMUST00000048068.6 ENSMUST00000048068.7 ENSMUST00000048068.8 ENSMUST00000048068.9 NM_001042592 Q8VD69 uc009hjh.1 uc009hjh.2 uc009hjh.3 Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:27462458). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (By similarity). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). May play a role in glucose uptake (By similarity). Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 (By similarity). Interacts with ADRB2. Interacts (via PPxY motifs) with ITCH, NEDD4L and WWP2. Interacts with AVPR2. Identified in a complex containing at least ARRDC4, AVPR2 and HGS (By similarity). Interacts with SLC11A2; controls the incorporation of SLC11A2 into extracellular vesicles through an ubiquitination-dependent mechanism (PubMed:27462458). Interacts with TRIM65 (By similarity). Early endosome Cell membrane eripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle Note=Also found in extracellular vesicles different from exosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A0A0B4J1F4-1; Sequence=Displayed; Name=2; IsoId=A0A0B4J1F4-2; Sequence=VSP_058000, VSP_058001; Up-regulated by high iron diet. Belongs to the arrestin family. endosome early endosome plasma membrane protein transport membrane protein ubiquitination cytoplasmic vesicle positive regulation of ubiquitin-protein transferase activity extracellular vesicle protein binding, bridging involved in substrate recognition for ubiquitination ubiquitin-dependent protein catabolic process uc009hjh.1 uc009hjh.2 uc009hjh.3 
ENSMUST00000048073.9 Pigs ENSMUST00000048073.9 phosphatidylinositol glycan anchor biosynthesis, class S, transcript variant 1 (from RefSeq NM_201406.2) ENSMUST00000048073.1 ENSMUST00000048073.2 ENSMUST00000048073.3 ENSMUST00000048073.4 ENSMUST00000048073.5 ENSMUST00000048073.6 ENSMUST00000048073.7 ENSMUST00000048073.8 NM_201406 PIGS_MOUSE Q6PD26 uc007kiz.1 uc007kiz.2 uc007kiz.3 Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates (By similarity). Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Forms a complex with PIGK/GPI8, PIGT, PIGU and GAA1. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the PIGS family. endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process membrane integral component of membrane attachment of GPI anchor to protein GPI-anchor transamidase complex GPI-anchor transamidase activity uc007kiz.1 uc007kiz.2 uc007kiz.3 
ENSMUST00000048077.12 Lime1 ENSMUST00000048077.12 Lck interacting transmembrane adaptor 1 (from RefSeq NM_023684.2) ENSMUST00000048077.1 ENSMUST00000048077.10 ENSMUST00000048077.11 ENSMUST00000048077.2 ENSMUST00000048077.3 ENSMUST00000048077.4 ENSMUST00000048077.5 ENSMUST00000048077.6 ENSMUST00000048077.7 ENSMUST00000048077.8 ENSMUST00000048077.9 LIME1_MOUSE Lime NM_023684 Q9EQR5 uc008omd.1 uc008omd.2 uc008omd.3 Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4- mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. When phosphorylated in response to TCR stimulation and/or CD4 costimulation, interacts with LCK, CSK, FYN, PTPN11/SHP2, GRB2, PIK3R1 and GRAP2 (By similarity). When phosphorylated in response to BCR activation, interacts with LYN, PIK3R1, PLCG2 and GRB2. Cell membrane ; Single-pass type III membrane protein Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell. Expressed in spleen and lung. Present in primary B- cells and peripheral T-cells (at protein level). Up-regulated in T-cells following TCR engagement. Palmitoylation of Cys-28 and Cys-31 is required for raft targeting. Phosphorylated on tyrosines upon TCR activation and/or CD4 coreceptor stimulation, or upon BCR stimulation; which leads to the recruitment of SH2-containing proteins. adaptive immune response immune system process protein binding plasma membrane regulation of transcription from RNA polymerase II promoter regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane B cell receptor complex protein kinase binding regulation of I-kappaB kinase/NF-kappaB signaling regulation of MAP kinase activity T cell receptor signaling pathway B cell receptor signaling pathway regulation of release of sequestered calcium ion into cytosol regulation of NIK/NF-kappaB signaling uc008omd.1 uc008omd.2 uc008omd.3 
ENSMUST00000048079.14 Fhip1b ENSMUST00000048079.14 FHF complex subunit HOOK interacting protein 1B, transcript variant 3 (from RefSeq NM_001242364.2) A0A1C7CYU5 A0A1C7CYU5_MOUSE ENSMUST00000048079.1 ENSMUST00000048079.10 ENSMUST00000048079.11 ENSMUST00000048079.12 ENSMUST00000048079.13 ENSMUST00000048079.2 ENSMUST00000048079.3 ENSMUST00000048079.4 ENSMUST00000048079.5 ENSMUST00000048079.6 ENSMUST00000048079.7 ENSMUST00000048079.8 ENSMUST00000048079.9 Fam160a2 Fhip1b NM_001242364 uc009iyb.1 uc009iyb.2 uc009iyb.3 uc009iyb.4 Belongs to the FHIP family. cytosol endosome organization lysosome organization endosome to lysosome transport early endosome to late endosome transport FHF complex uc009iyb.1 uc009iyb.2 uc009iyb.3 uc009iyb.4 
ENSMUST00000048096.12 Tlr4 ENSMUST00000048096.12 toll-like receptor 4 (from RefSeq NM_021297.3) ENSMUST00000048096.1 ENSMUST00000048096.10 ENSMUST00000048096.11 ENSMUST00000048096.2 ENSMUST00000048096.3 ENSMUST00000048096.4 ENSMUST00000048096.5 ENSMUST00000048096.6 ENSMUST00000048096.7 ENSMUST00000048096.8 ENSMUST00000048096.9 Lps NM_021297 Q9D691 Q9QUK6 Q9QZF5 Q9Z203 TLR4_MOUSE uc008thv.1 uc008thv.2 uc008thv.3 uc008thv.4 This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK030348.1, AF110133.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways (PubMed:9851930, PubMed:9989976, PubMed:20133493). At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:9851930, PubMed:9989976, PubMed:20133493). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:24380872). Alternatively, CD14- mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production. In addition to the secretion of proinflammatory cytokines, initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF-kappa-B signaling cascade. In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86. Upon ligand binding, such as oxLDL or amyloid- beta 42, the TLR4:TLR6 complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway. In myeloid dendritic cells, vesicular stomatitis virus glycoprotein G but not LPS promotes the activation of IRF7, leading to type I IFN production in a CD14- dependent manner (By similarity). (Microbial infection) Required for the virulence of fungus C.neoformans var. grubii serotype A (strain KN99) CPL1 (PubMed:35896747). Independently of Ly96/Md2, activated by CPL1 which results in a type 2 inflammation response characterized by Arg1/arginase-1 induction in interstitial macrophages (PubMed:35896747). Belongs to the lipopolysaccharide (LPS) receptor, a multi- protein complex containing at least CD14, LY96 and TLR4 (PubMed:24380872). Binding to bacterial LPS leads to homodimerization (PubMed:20133493, PubMed:24380872, PubMed:22532668). Interacts with LY96 via the extracellular domain (PubMed:17803912, PubMed:22532668). Interacts with MYD88 (via the TIR domain). Interacts with TICAM2 and TIRAP (PubMed:24380872). Interacts with NOX4 (By similarity). Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum (PubMed:18780723, PubMed:20865800). Interacts with MAP3K21; this interaction leads to negative regulation of TLR4 signaling (By similarity). Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR6. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation (By similarity). Interacts with TICAM1 in response to LPS in a WDFY1-dependent manner (PubMed:25736436). Interacts with WDFY1 in response to LPS (PubMed:25736436). Interacts with SMPDL3B (PubMed:26095358). Interacts with CEACAM1; upon lipopolysaccharide stimulation, forms a complex including TLR4 and the phosphorylated form of SYK and CEACAM1, which in turn, recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome (PubMed:22496641). Interacts with RFTN1; the interaction occurs in response to lipopolysaccharide stimulation (By similarity). Interacts with SCIMP; the interaction occurs in response to lipopolysaccharide stimulation and is enhanced by phosphorylation of SCIMP by LYN (PubMed:28098138). This interaction facilitates the phosphorylation of TLR4 by LYN which elicits a selective cytokine response in macrophages (PubMed:28098138). Interacts with TRAF3IP3 (By similarity). Interacts with TREM1; this interaction enhances TLR4-mediated inflammatory response (By similarity). Interacts with ZG16B/PAUF (By similarity). Q9QUK6; Q9JHF9: Ly96; NbExp=8; IntAct=EBI-1534575, EBI-1534566; Q9QUK6; P22366: Myd88; NbExp=2; IntAct=EBI-1534575, EBI-525108; Q9QUK6; Q91Y57: Siglec12; NbExp=3; IntAct=EBI-1534575, EBI-16826475; Q9QUK6; Q3U0V2: Tradd; NbExp=3; IntAct=EBI-1534575, EBI-1544032; Cell membrane ingle-pass type I membrane protein Early endosome Cell projection, ruffle Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis. Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation. Note=(Microbial infection) Endocytosed upon interaction with fungus C.neoformans var. grubii serotype A (strain KN99) CPL1 at the macrophage cell surface. Expressed in macrophages (at protein level) (PubMed:28098138, PubMed:35896747). Highly expressed in heart, spleen, lung and muscle. Lower levels are found in liver and kidney (PubMed:23812099). The TIR domain mediates interaction with NOX4. Phosphorylated on tyrosine residues by LYN after binding lipopolysaccharide. Interstrain analysis reveals that TLR4 is a polymorphic protein and that the extracellular domain is far more variable than the cytoplasmic domain, which is variable at the C-terminal. Note=The protein is encoded by the Lps locus, an important susceptibility locus, influencing the propensity to develop a disseminated Gram-negative infection. Mice infected with C.neoformans var. grubii serotype A (strain KN99) display reduced Arg1/arginase-1 expression in interstitial macrophages as well as reduced pulmonary fungal burden and eosinophilia (PubMed:35896747). Animals with a double knockout of Apoe and Tlr4, fed a Western diet for 12 weeks, have less aortic plaque formation than single Apoe knockout mice. They also show lower serum concentrations of Il1a, Ilb and Il18 (PubMed:23812099). Belongs to the Toll-like receptor family. In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity. activation of MAPK activity lipopolysaccharide binding microglial cell activation lipopolysaccharide receptor activity phagocytic cup activation of innate immune response toll-like receptor signaling pathway B cell proliferation involved in immune response immune system process nitric oxide production involved in inflammatory response regulation of dendritic cell cytokine production MyD88-dependent toll-like receptor signaling pathway innate immune response-activating signal transduction receptor binding protein binding cytoplasm endosome early endosome plasma membrane integral component of plasma membrane leukotriene metabolic process phagocytosis inflammatory response response to oxidative stress signal transduction activation of NF-kappaB-inducing kinase activity I-kappaB phosphorylation response to bacterium external side of plasma membrane cell surface positive regulation of platelet activation positive regulation of gene expression positive regulation of keratinocyte proliferation astrocyte development membrane integral component of membrane positive regulation of B cell proliferation intrinsic component of plasma membrane lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide detection of lipopolysaccharide interferon-gamma production negative regulation of interferon-gamma production negative regulation of interleukin-17 production negative regulation of interleukin-23 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of chemokine production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-1 production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway macrophage activation positive regulation of tumor necrosis factor biosynthetic process defense response to bacterium identical protein binding positive regulation of macrophage activation positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling receptor complex positive regulation of DNA binding phosphatidylinositol 3-kinase binding positive regulation of interleukin-12 biosynthetic process innate immune response positive regulation of MHC class II biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of interleukin-1 biosynthetic process positive regulation of interleukin-13 biosynthetic process positive regulation of interleukin-6 biosynthetic process positive regulation of interleukin-8 biosynthetic process positive regulation of nitric oxide biosynthetic process response to ethanol mast cell activation positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade lipopolysaccharide receptor complex protein heterodimerization activity perinuclear region of cytoplasm positive regulation of lymphocyte proliferation interleukin-1 beta secretion positive regulation of interleukin-1 beta secretion regulation of inflammatory response positive regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of nitric-oxide synthase biosynthetic process regulation of sensory perception of pain intestinal epithelial structure maintenance positive regulation of macrophage cytokine production negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway response to fatty acid cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to mechanical stimulus cellular response to interferon-gamma positive regulation of cytokine production involved in inflammatory response positive regulation of NLRP3 inflammasome complex assembly positive regulation of NIK/NF-kappaB signaling positive regulation of oxidative stress-induced neuron death positive regulation of reactive oxygen species biosynthetic process positive regulation of cellular response to macrophage colony-stimulating factor stimulus positive regulation of chemokine (C-C motif) ligand 2 secretion positive regulation of matrix metallopeptidase secretion regulation of tumor necrosis factor secretion cellular response to beta-amyloid positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion membrane raft uc008thv.1 uc008thv.2 uc008thv.3 uc008thv.4 
ENSMUST00000048099.5 Nemp1 ENSMUST00000048099.5 nuclear envelope integral membrane protein 1, transcript variant 1 (from RefSeq NM_001113211.1) ENSMUST00000048099.1 ENSMUST00000048099.2 ENSMUST00000048099.3 ENSMUST00000048099.4 Kiaa0286 NEMP1_MOUSE NM_001113211 Q6ZQE4 Tmem194 Tmem194a uc007hkg.1 uc007hkg.2 uc007hkg.3 uc007hkg.4 Together with EMD, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). Required for female fertility (PubMed:32923640). Homooligomer (By similarity). Interacts with RAN-GTP (PubMed:25946333). Interacts with EMD (By similarity). Q6ZQE4; P62827: Ran; NbExp=7; IntAct=EBI-12595939, EBI-286564; Nucleus inner membrane ; Multi-pass membrane protein ; Nucleoplasmic side Nucleus envelope Note=Colocalizes with lamins and RAN-GTP at the nuclear envelope. In the ovary, expression is strongest in primordial follicle oocytes and rapidly declines as oocytes mature and move from the cortex (at protein level). The transmembrane domains are required and sufficient for its oligomerization. Phosphorylated. Phosphorylation may regulate its interaction with RAN-GTP. Mutants are viable and generally healthy although anemic (PubMed:32923640). Most females are sterile or severely subfertile while males are fertile (PubMed:32923640). Marked reduction in the number of primordial follicles, indicating a reduced ovarian reserve, and oocytes have reduced nuclear envelope stiffness (PubMed:32923640). Belongs to the NEMP family. Sequence=BAC97920.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding nucleus nuclear envelope nuclear inner membrane biological_process membrane integral component of membrane uc007hkg.1 uc007hkg.2 uc007hkg.3 uc007hkg.4 
ENSMUST00000048103.9 Bpifa2 ENSMUST00000048103.9 BPI fold containing family A, member 2 (from RefSeq NM_008953.2) A2AIF8 BPIA2_MOUSE ENSMUST00000048103.1 ENSMUST00000048103.2 ENSMUST00000048103.3 ENSMUST00000048103.4 ENSMUST00000048103.5 ENSMUST00000048103.6 ENSMUST00000048103.7 ENSMUST00000048103.8 NM_008953 P07743 Psp Q9D734 uc008nis.1 uc008nis.2 uc008nis.3 Has strong antibacterial activity against P. aeruginosa. Secreted Predominates in the parotid glands, present in smaller amounts (1/10) in the submaxillary glands and in the sublingual glands, and at lower amount in the pancreas but undetectable in the liver. Found also in lacrimal gland. Expressed at low levels at day 3 after birth but increased gradually with age from this time. Belongs to the BPI/LBP/Plunc superfamily. Plunc family. lipopolysaccharide binding extracellular region biological_process lipid binding secretory granule defense response to bacterium uc008nis.1 uc008nis.2 uc008nis.3 
ENSMUST00000048112.13 Sgsm1 ENSMUST00000048112.13 small G protein signaling modulator 1, transcript variant 1 (from RefSeq NM_172718.3) B2RQR5 B2RQR5_MOUSE ENSMUST00000048112.1 ENSMUST00000048112.10 ENSMUST00000048112.11 ENSMUST00000048112.12 ENSMUST00000048112.2 ENSMUST00000048112.3 ENSMUST00000048112.4 ENSMUST00000048112.5 ENSMUST00000048112.6 ENSMUST00000048112.7 ENSMUST00000048112.8 ENSMUST00000048112.9 NM_172718 Sgsm1 uc008yud.1 uc008yud.2 uc008yud.3 Belongs to the RUTBC family. GTPase activator activity cytosol Rab GTPase binding cytoplasmic vesicle membrane positive regulation of GTPase activity uc008yud.1 uc008yud.2 uc008yud.3 
ENSMUST00000048116.15 Slc7a1 ENSMUST00000048116.15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1, transcript variant 1 (from RefSeq NM_007513.4) ENSMUST00000048116.1 ENSMUST00000048116.10 ENSMUST00000048116.11 ENSMUST00000048116.12 ENSMUST00000048116.13 ENSMUST00000048116.14 ENSMUST00000048116.2 ENSMUST00000048116.3 ENSMUST00000048116.4 ENSMUST00000048116.5 ENSMUST00000048116.6 ENSMUST00000048116.7 ENSMUST00000048116.8 ENSMUST00000048116.9 NM_007513 Q3UGD6 Q3UGD6_MOUSE Slc7a1 uc009aos.1 uc009aos.2 uc009aos.3 Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143, ChEBI:CHEBI:32682; Evidence=; Reaction=L-lysine(in) = L-lysine(out); Xref=Rhea:RHEA:70935, ChEBI:CHEBI:32551; Evidence=; Reaction=L-ornithine(in) = L-ornithine(out); Xref=Rhea:RHEA:71199, ChEBI:CHEBI:46911; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. amino acid transport membrane integral component of membrane transmembrane transporter activity macromolecular complex transmembrane transport uc009aos.1 uc009aos.2 uc009aos.3 
ENSMUST00000048121.13 Myrip ENSMUST00000048121.13 myosin VIIA and Rab interacting protein (from RefSeq NM_144557.5) A1L320 A1L321 ENSMUST00000048121.1 ENSMUST00000048121.10 ENSMUST00000048121.11 ENSMUST00000048121.12 ENSMUST00000048121.2 ENSMUST00000048121.3 ENSMUST00000048121.4 ENSMUST00000048121.5 ENSMUST00000048121.6 ENSMUST00000048121.7 ENSMUST00000048121.8 ENSMUST00000048121.9 MYRIP_MOUSE NM_144557 Q8CFC0 Q8K3I4 Q8K4H5 Slac2c uc009scn.1 uc009scn.2 uc009scn.3 Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release. Binds RAB27A that has been activated by GTP-binding via its N- terminus. Binds MYO5A, MYO7A and F-actin. Interacts with PRKAR2A. Interacts with components of the exocyst complex, including EXOC3 and EXOC4. Cytoplasm Cytoplasm, perinuclear region Cytoplasmic vesicle, secretory vesicle Melanosome Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments. In insulin- secreting cells, associated with dense core secretory granules. Detected in brain, skin, heart, lung, adrenal medulla, pancreas, intestine, liver, kidney, skeletal muscle and testis. Detected in cochlear and vestibular hair cells in the inner ear, and in photoreceptor and pigment epithelium cells in the retina. exocyst photoreceptor outer segment actin binding protein binding cytoplasm intracellular protein transport actin cytoskeleton apical plasma membrane myosin binding Rab GTPase binding vesicle transport along actin filament transport vesicle secretory granule membrane cortical actin cytoskeleton dense core granule cytoplasmic vesicle positive regulation of insulin secretion melanosome synapse metal ion binding perinuclear region of cytoplasm protein kinase A binding uc009scn.1 uc009scn.2 uc009scn.3 
ENSMUST00000048128.15 Zbtb7a ENSMUST00000048128.15 zinc finger and BTB domain containing 7a, transcript variant 1 (from RefSeq NM_010731.4) B2RRP7 B7ZNL6 ENSMUST00000048128.1 ENSMUST00000048128.10 ENSMUST00000048128.11 ENSMUST00000048128.12 ENSMUST00000048128.13 ENSMUST00000048128.14 ENSMUST00000048128.2 ENSMUST00000048128.3 ENSMUST00000048128.4 ENSMUST00000048128.5 ENSMUST00000048128.6 ENSMUST00000048128.7 ENSMUST00000048128.8 ENSMUST00000048128.9 Lrf NM_010731 O88939 Q3U372 Q9CRJ0 ZBT7A_MOUSE Zbtb7 Zbtb7a uc007gfz.1 uc007gfz.2 uc007gfz.3 Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:15337766, PubMed:15662416, PubMed:17495164, PubMed:26816381, PubMed:29813070). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:15337766, PubMed:15662416, PubMed:26816381, PubMed:29813070). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (By similarity). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (By similarity). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (PubMed:29813070). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (By similarity). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (By similarity). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (PubMed:15662416). Efficiently abrogates E2F1-dependent CDKN2A transactivation (PubMed:15662416). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (PubMed:15337766). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (By similarity). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (By similarity). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (PubMed:17495164). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (PubMed:17495164). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (PubMed:26446488). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (PubMed:26446488). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (By similarity). Homodimer (By similarity). Interacts with BCL6 (PubMed:9927193). Interacts with RELA; involved in the control by RELA of the accessibility of target gene promoters (PubMed:29813070). Interacts with AR (via NR LBD domain); the interaction is direct and androgen-dependent (By similarity). Interacts with NCOR1 (By similarity). Interacts with NCOR2 (By similarity). Interacts with SMAD4; the interaction is direct and stimulated by TGFB1 (By similarity). Interacts with HDAC1 (By similarity). Interacts with SP1; ZBTB7A prevents the binding to GC-rich motifs in promoters and represses the transcriptional activity of SP1 (By similarity). Interacts with the DNA-dependent protein kinase complex/DNA-PKc (PubMed:26446488). Interacts with KHDRBS1; negatively regulates KHDRBS1 splicing activity (By similarity). O88939; O09106: Hdac1; NbExp=3; IntAct=EBI-595063, EBI-301912; Nucleus te=Recruited to double-strand break sites of damaged DNA. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88939-1; Sequence=Displayed; Name=2; IsoId=O88939-2; Sequence=VSP_035026; Widely expressed (PubMed:9927193). In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level) (PubMed:15662416). In the spleen, mainly expressed in the white pulp germinal centers (at protein level) (PubMed:15662416). Up-regulated in thymic lymphomas (PubMed:15662416). Expressed at 9.5-10.0 dpc in limb buds, pharyngeal arches, tail bud, placenta and neural tube (PubMed:9927193). Up- regulated during adipocyte differentiation (PubMed:14701838). The BTB domain mediates the interaction with the androgen receptor/AR and HDAC1. Also mediates the interaction with SP1. Sumoylated. Undergoes sumoylation with SUMO1 that may regulate its transcriptional activity. Death around 16.5 dpc because of severe anemia with a profound block in early B-cell development (PubMed:17495164). Conditional knockout in erythroid cells, leads to the expression of fetal globin in peripheral blood of adult mice and inefficient erythroid terminal differentiation (PubMed:26816381). negative regulation of transcription from RNA polymerase II promoter regulation of alternative mRNA splicing, via spliceosome RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription corepressor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus cytoplasm regulation of glycolytic process DNA repair chromatin organization chromatin remodeling transcription, DNA-templated regulation of transcription, DNA-templated cellular response to DNA damage stimulus multicellular organism development NuRD complex cell differentiation B cell differentiation negative regulation of transforming growth factor beta receptor signaling pathway activating transcription factor binding protein localization to nucleus histone acetyltransferase binding regulation of apoptotic process erythrocyte maturation sequence-specific DNA binding fat cell differentiation regulation of osteoclast differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated SMAD binding metal ion binding androgen receptor binding regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity cartilage development negative regulation of androgen receptor signaling pathway DNA-dependent protein kinase complex double-strand break repair via classical nonhomologous end joining regulation of transcription regulatory region DNA binding site of double-strand break uc007gfz.1 uc007gfz.2 uc007gfz.3 
ENSMUST00000048129.6 Piwil2 ENSMUST00000048129.6 piwi-like RNA-mediated gene silencing 2, transcript variant 1 (from RefSeq NM_021308.2) A6H617 ENSMUST00000048129.1 ENSMUST00000048129.2 ENSMUST00000048129.3 ENSMUST00000048129.4 ENSMUST00000048129.5 Mili NM_021308 PIWL2_MOUSE Piwil2 Q3TQE8 Q8CDG1 Q99MV6 Q9JMB6 uc007unx.1 uc007unx.2 uc007unx.3 Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:11578866, PubMed:14736746, PubMed:17446352, PubMed:18381894, PubMed:18922463, PubMed:26669262). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (PubMed:11578866, PubMed:14736746, PubMed:17446352, PubMed:18381894, PubMed:18922463, PubMed:26669262). Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females (PubMed:11578866, PubMed:14736746, PubMed:17446352, PubMed:18381894, PubMed:18922463, PubMed:26669262). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (PubMed:11578866, PubMed:14736746, PubMed:17446352, PubMed:18381894, PubMed:18922463, PubMed:26669262). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (PubMed:22020280, PubMed:23706823, PubMed:26669262). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (PubMed:28633017). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (PubMed:18381894, PubMed:18922463, PubMed:26669262). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (PubMed:19114715). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (PubMed:16261612). Represses circadian rhythms by promoting the stability and activity of core clock components BMAL1 and CLOCK by inhibiting GSK3B-mediated phosphorylation and ubiquitination-dependent degradation of these proteins (PubMed:28903391). Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with DDX4, MAEL, EIF3A, EIF4E, EIF4G, PRMT5 and WDR77. Associates with EIF4E- and EIF4G-containing m7G cap-binding complexes. Interacts (when methylated on arginine residues) with TDRD1 and TDRKH/TDRD2. Interacts with TDRD12 (PubMed:24067652). Component of the PET complex, at least composed of EXD1, PIWIL2, TDRD12 and piRNAs (PubMed:26669262). Interacts with MOV10L1 (PubMed:20534472, PubMed:20547853). Interacts with GPAT2 (PubMed:23611983). Interacts with Tex19.1 and, probably, Tex19.2 (PubMed:28254886). Interacts (via PIWI domain) with BMAL1 and CLOCK (PubMed:28903391). Interacts with GSK3B (PubMed:28903391). Interacts with TEX15 (PubMed:32381626). Q8CDG1; Q99MV1: Tdrd1; NbExp=6; IntAct=EBI-8573412, EBI-8573364; Cytoplasm te=Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (PubMed:20439430). Expressed in adult testis, specifically in spermatocytes and in spermatogonia (PubMed:11279525, PubMed:11578866, PubMed:12906857, PubMed:18404146, PubMed:18922463, PubMed:19114715, PubMed:19377467, PubMed:28903391). Only detected in primordial germ cells of both sexes. Widely expressed in tumors. Also present at early stages of oocyte growth. Present in the mitotic spermatogonia (PubMed:23706823). Not detected in the first stages of meiosis (preleptotene and leptotene) (PubMed:23706823). Detected at the late zygotene stage and increases throughout pachytene, declining from this stage onward until expression stops at the early round spermatid stage (at protein level) (PubMed:23706823). Expressed from 12.5 dpc until adult in male gonads. In female gonads, detected since 12.5 dpc, then begins to cease after birth and disappears until the development of adult ovary (PubMed:11578866). Highly expressed in embryonic male germ cells at embryonic day 16.5 and expression decreases by postnatal day 2.5 (PubMed:32381626). Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein TDRD1 and subsequent localization to the meiotic nuage, also named P granule. Mice exhibit blocked spermatogenesis at the early prophase of the first meiosis due to transposable elements derepression, and apoptosis occurs subsequently. Female mice are fertile, while male are sterile. Belongs to the argonaute family. Piwi subfamily. Sequence=AAK31965.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; RNA 5'-end processing nucleic acid binding RNA binding mRNA binding nuclease activity endonuclease activity endoribonuclease activity protein binding nucleus cytoplasm cytosol regulation of translation multicellular organism development spermatogenesis perinucleolar chromocenter negative regulation of transposition hydrolase activity cell differentiation germ-line stem cell population maintenance gene silencing by RNA chromatoid body piRNA binding piRNA metabolic process negative regulation of circadian rhythm DNA methylation involved in gamete generation P granule positive regulation of translation metal ion binding oogenesis rhythmic process meiotic cell cycle positive regulation of meiosis I positive regulation of histone H3-K14 acetylation pi-body nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic dense body polysome binding piRNA biosynthetic process PET complex positive regulation of histone H3-K9 acetylation uc007unx.1 uc007unx.2 uc007unx.3 
ENSMUST00000048139.12 Wrap53 ENSMUST00000048139.12 WD repeat containing, antisense to Trp53, transcript variant 1 (from RefSeq NM_144824.3) ENSMUST00000048139.1 ENSMUST00000048139.10 ENSMUST00000048139.11 ENSMUST00000048139.2 ENSMUST00000048139.3 ENSMUST00000048139.4 ENSMUST00000048139.5 ENSMUST00000048139.6 ENSMUST00000048139.7 ENSMUST00000048139.8 ENSMUST00000048139.9 NM_144824 Q8VC51 TCAB1_MOUSE Tcab1 Wdr79 Wrap53 uc007jqj.1 uc007jqj.2 uc007jqj.3 RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (By similarity). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (By similarity). In addition, also controls telomerase holoenzyme complex localization to Cajal body (By similarity). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (By similarity). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (By similarity). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (By similarity). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non- homologous end joining (NHEJ) (By similarity). Component of the telomerase holoenzyme complex composed of one molecule of TERT, one molecule of WRAP53/TCAB1, two molecules of H/ACA ribonucleoprotein complex subunits DKC1, NOP10, NHP2 and GAR1, and a telomerase RNA template component (TERC). The telomerase holoenzyme complex is associated with TEP1, SMG6/EST1A and POT1. Interacts with the chaperonin-containing T-complex (TRiC) complex; which mediates the folding of WRAP53/TCAB1. Interacts with COIL. Interacts with SMN1. Interacts with RNF8. Interacts with histone H2AX. Nucleus, Cajal body Chromosome, telomere Chromosome Note=Released from telomerase RNA template component (TERC) in mitotic cells coincident with delocalization from Cajal bodies. In response to DNA damage, localizes to sites of DNA double-strand breaks following phosphorylation by ATM. Phosphorylated at Ser-61 by ATM in response to DNA damage, promoting its interaction with histone H2AX and localization to sites of DNA double-strand breaks. Belongs to the TCAB1 family. chromosome, telomeric region RNA binding nucleus nucleoplasm chromosome telomerase holoenzyme complex cytosol DNA repair cellular response to DNA damage stimulus telomere maintenance via telomerase Cajal body nuclear body Cajal body organization ubiquitin protein ligase binding telomere formation via telomerase RNA folding site of double-strand break histone binding identical protein binding macromolecular complex binding positive regulation of DNA repair chaperone binding positive regulation of telomerase activity telomerase RNA binding scaRNA localization to Cajal body telomerase RNA localization to Cajal body positive regulation of establishment of protein localization to telomere protein localization to Cajal body positive regulation of double-strand break repair via homologous recombination positive regulation of double-strand break repair positive regulation of double-strand break repair via nonhomologous end joining uc007jqj.1 uc007jqj.2 uc007jqj.3 
ENSMUST00000048150.15 Cc2d2a ENSMUST00000048150.15 coiled-coil and C2 domain containing 2A, transcript variant 1 (from RefSeq NM_172274.2) C2D2A_MOUSE ENSMUST00000048150.1 ENSMUST00000048150.10 ENSMUST00000048150.11 ENSMUST00000048150.12 ENSMUST00000048150.13 ENSMUST00000048150.14 ENSMUST00000048150.2 ENSMUST00000048150.3 ENSMUST00000048150.4 ENSMUST00000048150.5 ENSMUST00000048150.6 ENSMUST00000048150.7 ENSMUST00000048150.8 ENSMUST00000048150.9 NM_172274 Q8BP57 Q8CFW7 uc008xhp.1 uc008xhp.2 uc008xhp.3 uc008xhp.4 uc008xhp.5 Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling. Part of the tectonic-like complex (also named B9 complex). Cytoplasm Cytoplasm, cytoskeleton, cilium basal body Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CFW7-1; Sequence=Displayed; Name=2; IsoId=Q8CFW7-2; Sequence=VSP_030925; Embryos show randomized left-right axes, holoprosencephaly, microphthalmia and a variably expressive curved body axis. Cc2d2a null embryos also have cilia defects, which are exemplified by the absence of Arl13b staining in neural tube and surrounding mesenchyme. neural tube closure protein binding cytoplasm cytoskeleton cilium smoothened signaling pathway determination of left/right symmetry heart development cell projection organization axoneme assembly ciliary transition zone MKS complex cell projection camera-type eye development motile cilium assembly cilium assembly protein localization to ciliary transition zone non-motile cilium assembly embryonic brain development uc008xhp.1 uc008xhp.2 uc008xhp.3 uc008xhp.4 uc008xhp.5 
ENSMUST00000048155.16 Rbm25 ENSMUST00000048155.16 RNA binding motif protein 25, transcript variant 3 (from RefSeq NM_027349.4) B2RY56 ENSMUST00000048155.1 ENSMUST00000048155.10 ENSMUST00000048155.11 ENSMUST00000048155.12 ENSMUST00000048155.13 ENSMUST00000048155.14 ENSMUST00000048155.15 ENSMUST00000048155.2 ENSMUST00000048155.3 ENSMUST00000048155.4 ENSMUST00000048155.5 ENSMUST00000048155.6 ENSMUST00000048155.7 ENSMUST00000048155.8 ENSMUST00000048155.9 NM_027349 Q3TPH6 Q3U976 Q3UQU7 Q6NWW2 Q8BVT8 Q91XE6 Q9CT27 Q9CT49 RBM25_MOUSE uc007odm.1 uc007odm.2 uc007odm.3 uc007odm.4 RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA (By similarity). Interacts with LUC7L3 and SRRM1 (By similarity). Specifically associates with functional splicing complexes, including Sm proteins and U1, U2, U4, U5 and U6 snRNAs (By similarity). Associates with exon junction complex (EJC) proteins, including APEX1, DDX39B, NCBP1, RBM8A and RNPS1. Interaction with NCBP1 is RNA-dependent (By similarity). Nucleus speckle toplasm Note=Colocalizes predominantly, with SFRS2 and LUC7L3 splicing factors, in nuclear speckles. Cytoplasmic localization is faint (By similarity). The PWI domain binds nucleic acids with significant help from its N-terminal flanking basic region. It has an equal preference for binding to single- or double-stranded species, and it contributes to RBM25 role in modulation of alternative splicing, maybe by mediating RNA-dependent association with LUC7L3 (By similarity). Sumoylated. Sequence=AAH10792.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH10792.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=AAH66150.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH67400.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI58105.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; Sequence=BAB27451.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE24941.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding nucleus cytoplasm mRNA processing apoptotic process RNA splicing nuclear speck regulation of apoptotic process uc007odm.1 uc007odm.2 uc007odm.3 uc007odm.4 
ENSMUST00000048162.10 Bsdc1 ENSMUST00000048162.10 BSD domain containing 1 (from RefSeq NM_133889.2) B2KGE2 BSDC1_MOUSE ENSMUST00000048162.1 ENSMUST00000048162.2 ENSMUST00000048162.3 ENSMUST00000048162.4 ENSMUST00000048162.5 ENSMUST00000048162.6 ENSMUST00000048162.7 ENSMUST00000048162.8 ENSMUST00000048162.9 NM_133889 Q80Y55 Q8BI04 Q8VDP1 uc008uxb.1 uc008uxb.2 uc008uxb.3 uc008uxb.4 Sequence=AAH21480.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc008uxb.1 uc008uxb.2 uc008uxb.3 uc008uxb.4 
ENSMUST00000048183.8 Fmod ENSMUST00000048183.8 fibromodulin (from RefSeq NM_021355.4) ENSMUST00000048183.1 ENSMUST00000048183.2 ENSMUST00000048183.3 ENSMUST00000048183.4 ENSMUST00000048183.5 ENSMUST00000048183.6 ENSMUST00000048183.7 Fmod NM_021355 Q543D2 Q543D2_MOUSE uc007crd.1 uc007crd.2 uc007crd.3 Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis. Binds to type I and type II collagen. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. collagen fibril organization uc007crd.1 uc007crd.2 uc007crd.3 
ENSMUST00000048184.4 Pdcd7 ENSMUST00000048184.4 programmed cell death 7 (from RefSeq NM_016688.2) ENSMUST00000048184.1 ENSMUST00000048184.2 ENSMUST00000048184.3 NM_016688 Pdcd7 Q3U2X6 Q3U2X6_MOUSE uc009qdd.1 uc009qdd.2 uc009qdd.3 U12-type spliceosomal complex uc009qdd.1 uc009qdd.2 uc009qdd.3 
ENSMUST00000048187.6 Ppp1r14a ENSMUST00000048187.6 protein phosphatase 1, regulatory inhibitor subunit 14A, transcript variant 1 (from RefSeq NM_026731.4) Cpi17 ENSMUST00000048187.1 ENSMUST00000048187.2 ENSMUST00000048187.3 ENSMUST00000048187.4 ENSMUST00000048187.5 NM_026731 PP14A_MOUSE Q91VC7 Q99MB9 uc009gbn.1 uc009gbn.2 uc009gbn.3 Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). Cytoplasm Belongs to the PP1 inhibitor family. protein phosphatase inhibitor activity protein serine/threonine phosphatase inhibitor activity cytoplasm negative regulation of phosphoprotein phosphatase activity cellular response to drug regulation of phosphorylation uc009gbn.1 uc009gbn.2 uc009gbn.3 
ENSMUST00000048192.9 Haus1 ENSMUST00000048192.9 HAUS augmin-like complex, subunit 1, transcript variant 1 (from RefSeq NM_146089.3) Ccdc5 ENSMUST00000048192.1 ENSMUST00000048192.2 ENSMUST00000048192.3 ENSMUST00000048192.4 ENSMUST00000048192.5 ENSMUST00000048192.6 ENSMUST00000048192.7 ENSMUST00000048192.8 HAUS1_MOUSE NM_146089 Q3UIH2 Q8BHX1 Q8R1M1 uc008frs.1 uc008frs.2 uc008frs.3 Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect (By similarity). Interacts with EML3 (phosphorylated at 'Thr-882') (By similarity). Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=Localizes with the spindle poles in mitotic cells. In interphase, localized at the centrosome and diffusely in the cytoplasm. Localizes to mitotic spindle microtubules (By similarity). Belongs to the HAUS1 family. spindle pole molecular_function cytoplasm centrosome microtubule organizing center cytosol cytoskeleton microtubule cell cycle centrosome cycle spindle assembly cell division HAUS complex uc008frs.1 uc008frs.2 uc008frs.3 
ENSMUST00000048194.8 Tfap2e ENSMUST00000048194.8 transcription factor AP-2, epsilon (from RefSeq NM_198960.2) A2A883 AP2E_MOUSE ENSMUST00000048194.1 ENSMUST00000048194.2 ENSMUST00000048194.3 ENSMUST00000048194.4 ENSMUST00000048194.5 ENSMUST00000048194.6 ENSMUST00000048194.7 NM_198960 Q6VUP9 Tcfap2e uc008uts.1 uc008uts.2 uc008uts.3 Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Nucleus Expressed most prominently in the mitral cell layer of the developing olfactory bulb and to a lesser extent in the granule cell layer. Also expressed in skin, articular cartilage, primary chondrocytes, and chondrosarcoma cell line SW1353. Belongs to the AP-2 family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity uc008uts.1 uc008uts.2 uc008uts.3 
ENSMUST00000048197.10 Rhod ENSMUST00000048197.10 ras homolog family member D, transcript variant 1 (from RefSeq NM_007485.5) ENSMUST00000048197.1 ENSMUST00000048197.2 ENSMUST00000048197.3 ENSMUST00000048197.4 ENSMUST00000048197.5 ENSMUST00000048197.6 ENSMUST00000048197.7 ENSMUST00000048197.8 ENSMUST00000048197.9 NM_007485 Q545H8 Q545H8_MOUSE Rhod uc008gaa.1 uc008gaa.2 uc008gaa.3 nucleotide binding GTPase activity GTP binding small GTPase mediated signal transduction lamellipodium assembly positive regulation of cell migration positive regulation of cell adhesion focal adhesion assembly actin filament bundle assembly uc008gaa.1 uc008gaa.2 uc008gaa.3 
ENSMUST00000048207.10 Aipl1 ENSMUST00000048207.10 aryl hydrocarbon receptor-interacting protein-like 1 (from RefSeq NM_053245.2) AIPL1_MOUSE ENSMUST00000048207.1 ENSMUST00000048207.2 ENSMUST00000048207.3 ENSMUST00000048207.4 ENSMUST00000048207.5 ENSMUST00000048207.6 ENSMUST00000048207.7 ENSMUST00000048207.8 ENSMUST00000048207.9 NM_053245 Q5RI54 Q924K1 uc007jxy.1 uc007jxy.2 uc007jxy.3 uc007jxy.4 uc007jxy.5 May be important in protein trafficking and/or protein folding and stabilization. Interacts with NUB1. Cytoplasm Nucleus protein peptidyl-prolyl isomerization retina homeostasis photoreceptor inner segment farnesylated protein binding peptidyl-prolyl cis-trans isomerase activity nucleus nucleoplasm cytoplasm cytosol visual perception phototransduction, visible light protein farnesylation regulation of rhodopsin mediated signaling pathway negative regulation of apoptotic process uc007jxy.1 uc007jxy.2 uc007jxy.3 uc007jxy.4 uc007jxy.5 
ENSMUST00000048208.10 Ccdc122 ENSMUST00000048208.10 coiled-coil domain containing 122, transcript variant 1 (from RefSeq NM_175369.4) B2RSJ0 CC122_MOUSE ENSMUST00000048208.1 ENSMUST00000048208.2 ENSMUST00000048208.3 ENSMUST00000048208.4 ENSMUST00000048208.5 ENSMUST00000048208.6 ENSMUST00000048208.7 ENSMUST00000048208.8 ENSMUST00000048208.9 NM_175369 Q8BVN0 uc007urs.1 uc007urs.2 uc007urs.3 uc007urs.4 molecular_function cellular_component biological_process uc007urs.1 uc007urs.2 uc007urs.3 uc007urs.4 
ENSMUST00000048209.16 Ldha ENSMUST00000048209.16 lactate dehydrogenase A, transcript variant 1 (from RefSeq NM_010699.2) ENSMUST00000048209.1 ENSMUST00000048209.10 ENSMUST00000048209.11 ENSMUST00000048209.12 ENSMUST00000048209.13 ENSMUST00000048209.14 ENSMUST00000048209.15 ENSMUST00000048209.2 ENSMUST00000048209.3 ENSMUST00000048209.4 ENSMUST00000048209.5 ENSMUST00000048209.6 ENSMUST00000048209.7 ENSMUST00000048209.8 ENSMUST00000048209.9 G5E8N5 Ldh1 Ldha NM_010699 Q564E2 Q564E2_MOUSE uc009gzm.1 uc009gzm.2 uc009gzm.3 uc009gzm.4 The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to hemolytic anemia and early postimplantation death in mice. Multiple transcript variants encoding different isoforms have been found for this gene. The mouse genome contains multiple pseudogenes of this gene. [provided by RefSeq, May 2013]. Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate; Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27; Evidence=; Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. Cytoplasm Belongs to the LDH/MDH superfamily. LDH family. catalytic activity L-lactate dehydrogenase activity cytoplasm carbohydrate metabolic process oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor carboxylic acid metabolic process oxidation-reduction process uc009gzm.1 uc009gzm.2 uc009gzm.3 uc009gzm.4 
ENSMUST00000048214.9 Oosp1 ENSMUST00000048214.9 oocyte secreted protein 1 (from RefSeq NM_133353.3) ENSMUST00000048214.1 ENSMUST00000048214.2 ENSMUST00000048214.3 ENSMUST00000048214.4 ENSMUST00000048214.5 ENSMUST00000048214.6 ENSMUST00000048214.7 ENSMUST00000048214.8 If3 NM_133353 OOSP1_MOUSE Q3TSD1 Q8K4N9 Q925U0 uc008gst.1 uc008gst.2 uc008gst.3 May be involved in cell differentiation. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q925U0-1; Sequence=Displayed; Name=2; IsoId=Q925U0-2; Sequence=VSP_034664, VSP_034665; Expressed in oocytes in primary through antral- stage follicles. Expressed in liver and ovary. Expressed in preimplantation embryo. Expressed in liver at 16 dpc but not at 13 dpc. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the PLAC1 family. molecular_function extracellular region biological_process uc008gst.1 uc008gst.2 uc008gst.3 
ENSMUST00000048229.9 Myrfl ENSMUST00000048229.9 myelin regulatory factor-like (from RefSeq NM_001033333.3) ENSMUST00000048229.1 ENSMUST00000048229.2 ENSMUST00000048229.3 ENSMUST00000048229.4 ENSMUST00000048229.5 ENSMUST00000048229.6 ENSMUST00000048229.7 ENSMUST00000048229.8 Gm239 MRFL_MOUSE NM_001033333 Q3UN70 Q3UN89 uc007hci.1 uc007hci.2 uc007hci.3 Membrane ; Single-pass membrane protein Belongs to the MRF family. DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated membrane integral component of membrane sequence-specific DNA binding positive regulation of transcription, DNA-templated uc007hci.1 uc007hci.2 uc007hci.3 
ENSMUST00000048246.5 Fgb ENSMUST00000048246.5 fibrinogen beta chain (from RefSeq NM_181849.3) ENSMUST00000048246.1 ENSMUST00000048246.2 ENSMUST00000048246.3 ENSMUST00000048246.4 FIBB_MOUSE NM_181849 Q8K0E8 Q91ZP1 uc008pph.1 uc008pph.2 uc008pph.3 uc008pph.4 This gene encodes the beta subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded preproprotein is proteolytically processed by thrombin to release an N-terminal fibrinopeptide during the conversion of fibrinogen to insoluble fibrin polymer. The encoded protein interacts with the amyloid beta peptide to form fibrin clots of abnormal structure, and may play an important role in Alzheimer's disease. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146960.1, AK011118.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. Heterohexamer; disulfide linked. Contains 2 sets of 3 non- identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity). Secreted A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure (By similarity). Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. adaptive immune response immune system process receptor binding structural molecule activity extracellular matrix structural constituent extracellular region fibrinogen complex extracellular space cytoplasm endoplasmic reticulum cell cortex cell-matrix adhesion blood coagulation hemostasis external side of plasma membrane cell surface platelet activation platelet alpha granule plasminogen activation positive regulation of heterotypic cell-cell adhesion cellular macromolecular complex assembly fibrinolysis induction of bacterial agglutination cellular response to leptin stimulus innate immune response synapse positive regulation of vasoconstriction positive regulation of exocytosis positive regulation of protein secretion cell adhesion molecule binding chaperone binding protein polymerization response to calcium ion positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to interleukin-1 blood coagulation, fibrin clot formation blood microparticle positive regulation of peptide hormone secretion negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of endothelial cell apoptotic process uc008pph.1 uc008pph.2 uc008pph.3 uc008pph.4 
ENSMUST00000048248.9 Brsk1 ENSMUST00000048248.9 BR serine/threonine kinase 1, transcript variant 1 (from RefSeq NM_001003920.3) A7LH90 A7LH91 B7SRN7 BRSK1_MOUSE ENSMUST00000048248.1 ENSMUST00000048248.2 ENSMUST00000048248.3 ENSMUST00000048248.4 ENSMUST00000048248.5 ENSMUST00000048248.6 ENSMUST00000048248.7 ENSMUST00000048248.8 Gm1100 NM_001003920 Q5RJI5 Q699J6 Sadb uc009eyf.1 uc009eyf.2 Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl- [tau protein]; Xref=Rhea:RHEA:12801, Rhea:RHEA-COMP:13701, Rhea:RHEA- COMP:13702, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.26; Reaction=ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L- threonyl-[tau protein]; Xref=Rhea:RHEA:53904, Rhea:RHEA-COMP:13703, Rhea:RHEA-COMP:13704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.26; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation on Thr-189 by STK11/LKB1. Cytoplasm Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Synapse Presynaptic active zone Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Note=Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=SADB-Long, L; IsoId=Q5RJI5-1; Sequence=Displayed; Name=2; Synonyms=SADB-short, S; IsoId=Q5RJI5-2; Sequence=VSP_041745; Name=4; Synonyms=SADB-short 1, S1; IsoId=Q5RJI5-4; Sequence=VSP_041743, VSP_041745; Present in the gray matter of the brain and spinal cord (at protein level). Expressed in the nervous system, distributed within the brain and spinal cord of embryonic and postnatal animals. Activity is high in G0, decreases after serum addition, and increases transiently in advanced G1, at G1-S, and in S phases. Phosphorylated at Thr-189 by STK11/LKB1 in complex with STE20- related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-189 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-189 by PP2C. No visible phenotype. Mice are fertile and healthy. In contrast, mice lacking both Brsk1 and Brsk2 show little spontaneous movement and are only weakly responsive to tactile stimulation: they die within 2 hours of birth. Defects are due to impaired neuronal differentiation and polarity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. G2/M transition of mitotic cell cycle nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm centrosome microtubule organizing center cytoskeleton protein phosphorylation cellular response to DNA damage stimulus cell cycle mitotic G2 DNA damage checkpoint neurotransmitter secretion nervous system development axonogenesis synaptic vesicle associative learning response to UV regulation of neuron projection development kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation protein kinase binding establishment of cell polarity cell junction neuron differentiation intracellular signal transduction gamma-tubulin binding synapse metal ion binding regulation of synaptic plasticity neuron projection morphogenesis tau-protein kinase activity regulation of axonogenesis centrosome duplication microtubule cytoskeleton organization involved in establishment of planar polarity synaptic vesicle cycle uc009eyf.1 uc009eyf.2 
ENSMUST00000048249.8 Ndufa7 ENSMUST00000048249.8 NADH:ubiquinone oxidoreductase subunit A7, transcript variant 1 (from RefSeq NM_023202.4) ENSMUST00000048249.1 ENSMUST00000048249.2 ENSMUST00000048249.3 ENSMUST00000048249.4 ENSMUST00000048249.5 ENSMUST00000048249.6 ENSMUST00000048249.7 NDUA7_MOUSE NM_023202 Q9Z1P6 uc008bzu.1 uc008bzu.2 uc008bzu.3 uc008bzu.4 This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. Complex I has been biochemically separated into four fractions. The bovine ortholog of this protein has been reported to be part of the I-lambda fraction, which forms the extrinsic globular domain. In humans, deficiencies in complex I are associated with myopathies, encephalomyopathies, and neurodegenerative disorders. Pseudogenes of this gene are located on chromosomes 7 and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the complex I NDUFA7 subunit family. structural constituent of ribosome mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial ribosome mitochondrial electron transport, NADH to ubiquinone NADH dehydrogenase (ubiquinone) activity membrane mitochondrial translation ATP synthesis coupled electron transport oxidation-reduction process respiratory chain uc008bzu.1 uc008bzu.2 uc008bzu.3 uc008bzu.4 
ENSMUST00000048250.10 Tab3 ENSMUST00000048250.10 TGF-beta activated kinase 1/MAP3K7 binding protein 3, transcript variant 1 (from RefSeq NM_025729.4) ENSMUST00000048250.1 ENSMUST00000048250.2 ENSMUST00000048250.3 ENSMUST00000048250.4 ENSMUST00000048250.5 ENSMUST00000048250.6 ENSMUST00000048250.7 ENSMUST00000048250.8 ENSMUST00000048250.9 Kiaa4135 Map3k7ip3 NM_025729 Q571K4 TAB3_MOUSE uc009trt.1 uc009trt.2 uc009trt.3 Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys- 63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Interacts with DYNC2I2 (via the WD domains). Interacts with RBCK1. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with TRIM5. Interacts with TRIM38 (via B30.2/SPRY domain), leading to its translocation to lysosomes and degradation. Q571K4; P62991: Ubc; NbExp=2; IntAct=EBI-7606337, EBI-413074; The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins. Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitinated by AMFR via 'Lys-27'-linked polyubiquitination; leading to TAK1/MAP3K7 activation. Degraded in a lysosome-dependent manner following interactiuon with TRIM38. Phosphorylated at Ser-510 by MAPKAPK2 and MAPKAPK3 following IL1 treatment. Sequence=BAD90370.1; Type=Erroneous initiation; Evidence=; positive regulation of I-kappaB kinase/NF-kappaB signaling metal ion binding uc009trt.1 uc009trt.2 uc009trt.3 
ENSMUST00000048260.15 Lman1 ENSMUST00000048260.15 lectin, mannose-binding, 1, transcript variant 1 (from RefSeq NM_027400.3) ENSMUST00000048260.1 ENSMUST00000048260.10 ENSMUST00000048260.11 ENSMUST00000048260.12 ENSMUST00000048260.13 ENSMUST00000048260.14 ENSMUST00000048260.2 ENSMUST00000048260.3 ENSMUST00000048260.4 ENSMUST00000048260.5 ENSMUST00000048260.6 ENSMUST00000048260.7 ENSMUST00000048260.8 ENSMUST00000048260.9 Ergic53 LMAN1_MOUSE NM_027400 Q9D0F3 uc008ffn.1 uc008ffn.2 uc008ffn.3 uc008ffn.4 uc008ffn.5 Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins (By similarity). Exists both as a covalent disulfide-linked homohexamer, and a complex of three disulfide-linked dimers non-covalently kept together. Interacts with MCFD2. May interact with TMEM115. Interacts with RAB3GAP1 and RAB3GAP2. Interacts with UBXN6. Interacts with SERPINA1/alpha1-antitrypsin (By similarity). Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein Golgi apparatus membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein The FF ER export motif at the C-terminus is not sufficient to support endoplasmic reticulum exit, and needs assistance of Gln-508 for proper recognition of COPII coat components. Golgi membrane mannose binding endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus ER to Golgi vesicle-mediated transport endoplasmic reticulum organization Golgi organization positive regulation of organelle organization protein transport membrane integral component of membrane vesicle-mediated transport sarcomere ER to Golgi transport vesicle carbohydrate binding endoplasmic reticulum-Golgi intermediate compartment membrane identical protein binding intracellular membrane-bounded organelle host cell perinuclear region of cytoplasm metal ion binding uc008ffn.1 uc008ffn.2 uc008ffn.3 uc008ffn.4 uc008ffn.5 
ENSMUST00000048263.14 Wapl ENSMUST00000048263.14 WAPL cohesin release factor, transcript variant 1 (from RefSeq NM_001004436.4) B9EIG8 ENSMUST00000048263.1 ENSMUST00000048263.10 ENSMUST00000048263.11 ENSMUST00000048263.12 ENSMUST00000048263.13 ENSMUST00000048263.2 ENSMUST00000048263.3 ENSMUST00000048263.4 ENSMUST00000048263.5 ENSMUST00000048263.6 ENSMUST00000048263.7 ENSMUST00000048263.8 ENSMUST00000048263.9 Kiaa0261 NM_001004436 Q65Z40 Q6ZQE9 WAPL_MOUSE Wapal Wapl uc007tbi.1 uc007tbi.2 uc007tbi.3 Studies suggest that the protein encoded by this gene is important for the release of cohesin from chromatin. This gene product is thought to be essential for development, and reduced expression of this gene in cells causes defects in chromatin structure. High levels of expression of the human ortholog of this gene are observed in cervical cancers, and expression of the human ortholog of this gene in mice results in tumor formation. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Aug 2014]. Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity). Interacts with the cohesin complex throughout the cell cycle; interacts with both chromatin-bound and soluble pools of the complex. Interacts with RAD21; the interaction is direct (By similarity). Interacts with PDS5A; the interaction is direct, cohesin-dependent and competitive with CDCA5/SORORIN (By similarity). Interacts (via FGF motifs) with PDS5B; the interaction is direct (By similarity). Interacts with a SMC1 protein (SMC1A or SMC1B) and SMC3 (By similarity). Nucleus Chromosome Cytoplasm Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase (By similarity). Highly expressed in large pachytene spermatocytes of testis. Down-regulated by dioxin in testis. Deubiquitinated by USP37; leading to stabilization. Belongs to the WAPL family. Sequence=BAC97915.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; mitotic cell cycle chromatin synaptonemal complex molecular_function nucleus chromosome cytoplasm cell cycle negative regulation of DNA replication cohesin complex response to toxic substance negative regulation of chromatin binding meiotic chromosome segregation negative regulation of sister chromatid cohesion positive regulation of fibroblast proliferation cell division regulation of chromosome segregation regulation of chromosome condensation protein localization to chromatin regulation of cohesin loading uc007tbi.1 uc007tbi.2 uc007tbi.3 
ENSMUST00000048302.13 Asb10 ENSMUST00000048302.13 ankyrin repeat and SOCS box-containing 10, transcript variant 1 (from RefSeq NM_080444.5) ASB10_MOUSE B2RUP6 ENSMUST00000048302.1 ENSMUST00000048302.10 ENSMUST00000048302.11 ENSMUST00000048302.12 ENSMUST00000048302.2 ENSMUST00000048302.3 ENSMUST00000048302.4 ENSMUST00000048302.5 ENSMUST00000048302.6 ENSMUST00000048302.7 ENSMUST00000048302.8 ENSMUST00000048302.9 NM_080444 Q91ZT7 uc008wry.1 uc008wry.2 uc008wry.3 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Nucleus Cytoplasm The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Belongs to the ankyrin SOCS box (ASB) family. nucleus cytoplasm biological_process protein ubiquitination intracellular signal transduction uc008wry.1 uc008wry.2 uc008wry.3 
ENSMUST00000048305.10 Ppp4r3a ENSMUST00000048305.10 protein phosphatase 4 regulatory subunit 3A, transcript variant 1 (from RefSeq NM_211355.2) ENSMUST00000048305.1 ENSMUST00000048305.2 ENSMUST00000048305.3 ENSMUST00000048305.4 ENSMUST00000048305.5 ENSMUST00000048305.6 ENSMUST00000048305.7 ENSMUST00000048305.8 ENSMUST00000048305.9 Kiaa2010 NM_211355 P4R3A_MOUSE Pp4r3a Ppp4r3a Q3UF79 Q69Z35 Q6P2K6 Q80VS2 Q8BKP7 Smek1 uc007oti.1 uc007oti.2 uc007oti.3 uc007oti.4 Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair (By similarity). Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3A. Interacts with PPP4C; the interaction requires PPP4R2 (By similarity). Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P2K6-1; Sequence=Displayed; Name=2; IsoId=Q6P2K6-2; Sequence=VSP_021257; Belongs to the SMEK family. Sequence=BAD32609.1; Type=Erroneous initiation; Evidence=; protein binding nucleus nucleoplasm cytoplasm microtubule organizing center cytoskeleton protein dephosphorylation protein phosphatase 4 complex positive regulation of gluconeogenesis uc007oti.1 uc007oti.2 uc007oti.3 uc007oti.4 
ENSMUST00000048308.6 C130074G19Rik ENSMUST00000048308.6 RIKEN cDNA C130074G19 gene (from RefSeq NM_178692.3) ENSMUST00000048308.1 ENSMUST00000048308.2 ENSMUST00000048308.3 ENSMUST00000048308.4 ENSMUST00000048308.5 NM_178692 Q8BGN9 RDD1_MOUSE uc007dys.1 uc007dys.2 uc007dys.3 Regulates drug efflux through modulation of ABCB1 localization and activity. Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007dys.1 uc007dys.2 uc007dys.3 
ENSMUST00000048359.5 Tango6 ENSMUST00000048359.5 transport and golgi organization 6 (from RefSeq NM_173037.2) ENSMUST00000048359.1 ENSMUST00000048359.2 ENSMUST00000048359.3 ENSMUST00000048359.4 Kiaa1746 NM_173037 Q69ZB6 Q6NXV4 Q8C3S2 Q8C6M0 Q8C8G2 TNG6_MOUSE Tmco7 uc009ngl.1 uc009ngl.2 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C3S2-1; Sequence=Displayed; Name=2; IsoId=Q8C3S2-2; Sequence=VSP_028207, VSP_028208; Name=3; IsoId=Q8C3S2-3; Sequence=VSP_028206; Belongs to the Tango6 family. molecular_function cellular_component protein secretion membrane integral component of membrane uc009ngl.1 uc009ngl.2 
ENSMUST00000048363.10 Cox18 ENSMUST00000048363.10 cytochrome c oxidase assembly protein 18, transcript variant 2 (from RefSeq NM_001033310.4) A6H626 COX18_MOUSE ENSMUST00000048363.1 ENSMUST00000048363.2 ENSMUST00000048363.3 ENSMUST00000048363.4 ENSMUST00000048363.5 ENSMUST00000048363.6 ENSMUST00000048363.7 ENSMUST00000048363.8 ENSMUST00000048363.9 G3X965 NM_001033310 Oxa1l2 Q3U1D5 Q8VC74 uc008yar.1 uc008yar.2 uc008yar.3 uc008yar.4 uc008yar.5 Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). Found in a complex with TMEM177, COA6, MT-CO2/COX2, COX20, SCO1 and SCO2. Interacts transiently with MT-CO2/COX2 during its maturation. Interacts with COX20 in a MT-CO2/COX2-dependent manner. Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the OXA1/ALB3/YidC family. Sequence=AAH21612.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; mitochondrion mitochondrial inner membrane respiratory chain complex IV assembly membrane integral component of membrane integral component of mitochondrial inner membrane membrane insertase activity protein insertion into mitochondrial membrane from inner side mitochondrial respiratory chain complex IV assembly protein insertion into mitochondrial membrane protein insertion into membrane uc008yar.1 uc008yar.2 uc008yar.3 uc008yar.4 uc008yar.5 
ENSMUST00000048372.7 Tmem71 ENSMUST00000048372.7 transmembrane protein 71 (from RefSeq NM_172514.3) A0A0R4J0I5 A0A0R4J0I5_MOUSE ENSMUST00000048372.1 ENSMUST00000048372.2 ENSMUST00000048372.3 ENSMUST00000048372.4 ENSMUST00000048372.5 ENSMUST00000048372.6 NM_172514 Tmem71 uc007wad.1 uc007wad.2 uc007wad.3 mitochondrion membrane integral component of membrane uc007wad.1 uc007wad.2 uc007wad.3 
ENSMUST00000048374.6 Cip2a ENSMUST00000048374.6 cell proliferation regulating inhibitor of protein phosphatase 2A (from RefSeq NM_172616.2) B2RQ25 CIP2A_MOUSE ENSMUST00000048374.1 ENSMUST00000048374.2 ENSMUST00000048374.3 ENSMUST00000048374.4 ENSMUST00000048374.5 Kiaa1524 NM_172616 Q69ZH6 Q7TPZ7 Q8BWY9 uc007zkb.1 uc007zkb.2 Acts as an inhibitor of protein phosphatase PP2A (By similarity). Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies (By similarity). Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (By similarity). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (By similarity). Homodimer. Interacts with MYC. Interacts with PPP2R5C; this interaction stabilizes CIP2A. Interacts with PPP2R1A; this interaction stabilizes CIP2A. Interacts with TOPBP1; forming the CIP2A-TOPBP1 complex. Cytoplasm Chromosome Note=Predominantly localizes within the cytoplasm. Localizes to broken chromosomes within micronuclei during interphase and following chromothripsis. Localization to broken chromosomes is mainly independent of MDC1. Highly expressed in 17.5 and 18.5 dpc liver but not expressed in adult liver. Expressed at moderate level in embryonic brain, muscle and epidermal layers. Mice develop normally and do not display any abnormality with the exception of a mild spermatogenesis defect. Belongs to the CIP2A family. Sequence=BAC33705.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cytoplasm cytosol plasma membrane spermatogenesis membrane integral component of membrane protein homodimerization activity positive regulation of neural precursor cell proliferation uc007zkb.1 uc007zkb.2 
ENSMUST00000048375.6 Eeig1 ENSMUST00000048375.6 estrogen-induced osteoclastogenesis regulator 1 (from RefSeq NM_153560.5) EEIG1_MOUSE ENSMUST00000048375.1 ENSMUST00000048375.2 ENSMUST00000048375.3 ENSMUST00000048375.4 ENSMUST00000048375.5 Fam102a NM_153560 Q78T81 Q8K2K5 uc008jfs.1 uc008jfs.2 uc008jfs.3 Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (PubMed:23478294, PubMed:32741026). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (PubMed:23478294). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (PubMed:32741026). May play a role in estrogen action (By similarity). Part of a complex composed of EEIG1, TNFRSF11A/RANK, PLCG2, GAB2, TEC and BTK; complex formation increases in the presence of TNFSF11/RANKL (PubMed:23478294). Interacts with PRDM1/BLIMP1; following TNFSF11/RANKL stimulation in bone marrow-derived macrophages, the interaction promotes the binding of PRDM1/BLIMP1 to the gene promoter of IRF8 (PubMed:32741026). Interacts (via N-terminus) with TNFRSF11A/RANK (via cytoplasmic domain); when in the presence of TNFSF11/RANKL (PubMed:23478294). Nucleus Cytoplasm Membrane raft Expressed during TNFSF11/RANKL-induced differentiation of bone marrow-derived macrophages to osteoclasts. Induced by NFATC1 in bone marrow-derived macrophages (PubMed:23478294). Induced by TNFSF11/RANKL and TNF in bone marrow macrophages (PubMed:32741026). No effect on bone mass under homeostatic conditions, however reduces osteoclast number, amount of bone destruction, number of osteolytic cavities and abundance of serum Acp5/TRAP levels in a lipopolysaccharide-induced bone destruction model. Belongs to the EEIG family. Sequence=AAH31157.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc008jfs.1 uc008jfs.2 uc008jfs.3 
ENSMUST00000048377.11 Suco ENSMUST00000048377.11 SUN domain containing ossification factor, transcript variant 5 (from RefSeq NR_151684.1) ENSMUST00000048377.1 ENSMUST00000048377.10 ENSMUST00000048377.2 ENSMUST00000048377.3 ENSMUST00000048377.4 ENSMUST00000048377.5 ENSMUST00000048377.6 ENSMUST00000048377.7 ENSMUST00000048377.8 ENSMUST00000048377.9 NR_151684 Opt Q3TAG8 Q3V3T1 Q8C341 Q8CE34 SUCO_MOUSE uc007dft.1 uc007dft.2 uc007dft.3 uc007dft.4 Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation. Rough endoplasmic reticulum membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C341-1; Sequence=Displayed; Name=2; IsoId=Q8C341-2; Sequence=VSP_027924; Present in chondrocytes, osteoblasts, osteoclasts and osteocytes (at protein level). Expressed at 9.5 dpc and 13.5 dpc. N-glycosylated. O-glycosylated. O-mannosylated by POMT1 and POMT2 and elongated by POMGNT1. Most mice die neonatally from respiratory distress (50% on a mixed C57BL6/CD1 background and 100% on an inbred C57BL6/129Ola background). Surviving mice fail to thrive and show significantly reduced body weight, skeletal deformities and spontaneous fractures. More than 80% die by postnatal day 10, and none survives to weaning. ossification molecular_function cytoplasm endoplasmic reticulum rough endoplasmic reticulum multicellular organism development membrane integral component of membrane rough endoplasmic reticulum membrane positive regulation of collagen biosynthetic process positive regulation of osteoblast differentiation regulation of bone remodeling uc007dft.1 uc007dft.2 uc007dft.3 uc007dft.4 
ENSMUST00000048382.5 Fthl17a ENSMUST00000048382.5 ferritin, heavy polypeptide-like 17, member A (from RefSeq NM_028046.1) 1600014K23Rik ENSMUST00000048382.1 ENSMUST00000048382.2 ENSMUST00000048382.3 ENSMUST00000048382.4 Fthl17a NM_028046 Q9DAX0 Q9DAX0_MOUSE uc009trs.1 uc009trs.2 uc009trs.3 uc009trs.4 Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. ferroxidase activity iron ion binding cytoplasm iron ion transport cellular iron ion homeostasis intracellular sequestering of iron ion ferrous iron binding ferric iron binding identical protein binding metal ion binding oxidation-reduction process uc009trs.1 uc009trs.2 uc009trs.3 uc009trs.4 
ENSMUST00000048391.15 Clspn ENSMUST00000048391.15 claspin, transcript variant 5 (from RefSeq NM_175554.5) B1ARX6 CLSPN_MOUSE ENSMUST00000048391.1 ENSMUST00000048391.10 ENSMUST00000048391.11 ENSMUST00000048391.12 ENSMUST00000048391.13 ENSMUST00000048391.14 ENSMUST00000048391.2 ENSMUST00000048391.3 ENSMUST00000048391.4 ENSMUST00000048391.5 ENSMUST00000048391.6 ENSMUST00000048391.7 ENSMUST00000048391.8 ENSMUST00000048391.9 NM_175554 Q69GM2 Q80YR7 uc008utn.1 uc008utn.2 uc008utn.3 uc008utn.4 Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:27401717). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (By similarity). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication (PubMed:27401717). Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS. Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (By similarity). Interacts (phosphorylation-dependent) with CHEK1; regulates CLSPN function in checkpoint for DNA damage and replication. Interacts with ATR and RAD9A and these interactions are slightly reduced during checkpoint activation. Interacts with BRCA1 and this interaction increases during checkpoint activation. Interacts with TIMELESS; the interaction is required for leading-strand replication. Associates with the MCM2-7 complex and other replisome factors. Interacts (via the acidic patch) with CDC7; the interaction is required for phosphorylation of MCM proteins and CLASPIN by CDC7. Interacts with PCNA. Interacts with FZR1. Nucleus The C-terminus of the protein contains 3 potential CHEK1- binding motifs (CKB motifs). Potential phosphorylation sites within CKB motif 1 and CKB motif 2 are required for interaction with CHEK1 (By similarity). The acidic patch region is required for normal DNA replication. Interacts with the N-terminal segments and inhibits binding to DNA and PCNA. Mediates the interaction with the kinase CDC7 as well as some replisome factors and DNA polymerases. Phosphorylated. Undergoes ATR-dependent phosphorylation by CHEK1 during activation of DNA replication or damage checkpoints. Phosphorylation by CSNK1G1/CK1 promotes CHEK1 binding. Phosphorylated by CDC7 during DNA replication, phosphorylation inhibits interaction between the acidic patch and N-terminal segments leading to increased binding to DNA and PCNA. Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) during G1 phase, leading to its degradation by the proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Following DNA damage, it is deubiquitinated by USP28 in G2 phase, preventing its degradation (By similarity). Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation. Knockout enbryos die by E12.5. Belongs to the claspin family. DNA replication checkpoint DNA damage checkpoint DNA secondary structure binding DNA binding nucleus nucleoplasm chromosome Golgi apparatus DNA repair cellular response to DNA damage stimulus cell cycle mitotic G2 DNA damage checkpoint anaphase-promoting complex binding peptidyl-serine phosphorylation activation of protein kinase activity mitotic DNA replication checkpoint uc008utn.1 uc008utn.2 uc008utn.3 uc008utn.4 
ENSMUST00000048393.8 Atg101 ENSMUST00000048393.8 autophagy related 101, transcript variant 1 (from RefSeq NM_026566.3) ATGA1_MOUSE ENSMUST00000048393.1 ENSMUST00000048393.2 ENSMUST00000048393.3 ENSMUST00000048393.4 ENSMUST00000048393.5 ENSMUST00000048393.6 ENSMUST00000048393.7 NM_026566 Q9D8Z6 uc007xsw.1 uc007xsw.2 uc007xsw.3 Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. Interacts with ATG13. Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13. Cytoplasm Preautophagosomal structure Note=Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. Belongs to the ATG101 family. autophagosome assembly pre-autophagosomal structure cytoplasm autophagy identical protein binding macromolecular complex binding uc007xsw.1 uc007xsw.2 uc007xsw.3 
ENSMUST00000048402.12 Spata7 ENSMUST00000048402.12 spermatogenesis associated 7, transcript variant 1 (from RefSeq NM_178914.4) ENSMUST00000048402.1 ENSMUST00000048402.10 ENSMUST00000048402.11 ENSMUST00000048402.2 ENSMUST00000048402.3 ENSMUST00000048402.4 ENSMUST00000048402.5 ENSMUST00000048402.6 ENSMUST00000048402.7 ENSMUST00000048402.8 ENSMUST00000048402.9 NM_178914 Q80VP2 Q8BK23 SPAT7_MOUSE uc007ora.1 uc007ora.2 uc007ora.3 uc007ora.4 Involved in the maintenance of both rod and cone photoreceptor cells (PubMed:25398945, PubMed:29100828, PubMed:29899041). Required for photoreceptor-specific localization of proximal connecting cilium (CC) proteins RPGR, AHI1, NPHP1, NPHP4, and RPGRIP1 at the distal CC, a photoreceptor-specific extension of the primary cilium transition zone (PubMed:25398945, PubMed:29100828, PubMed:29899041). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (PubMed:25398945, PubMed:29899041). Found in a complex with CFAP410, NEK1 and SPATA7 (By similarity). Interacts with NEK1 (By similarity). Interacts with RPGRIP1 (PubMed:25398945, PubMed:29899041). Interacts with RPGR (PubMed:29899041). Interacts with NPHP4 (PubMed:29899041). Interacts with NPHP1 (PubMed:29899041). Interacts with AHI1 (PubMed:29899041). Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton Cell projection, cilium, photoreceptor outer segment te=Localizes to the microtubule network. Expressed in the retina (at protein level) (PubMed:19268277, PubMed:29100828, PubMed:29899041). Expressed in the choroid region and retinal pigment endothelium, within the photoreceptor layer (at protein level) (PubMed:25398945, PubMed:29100828, PubMed:29899041). Viable and fertile with no gross morphological abnormalities (PubMed:25398945). Knockout mice show severe early-onset retinal defects and progressive photoreceptor cell degeneration (PubMed:25398945). Significant and progressive reduction in response to light, accompanied by progressive thinning of the outer nuclear layer from P15 to 7 months, loss of Spata7-interacting proteins at the distal CC, and destabilization of the photoreceptor distal connecting cilium (CC) microtubule core (PubMed:25398945, PubMed:29899041). Impaired trafficking of photoreceptor proteins between the inner and outer nuclear segments resulting in loss of photoreceptor-specific protein localization at the distal CC (PubMed:25398945). Conditional knockdown of Spata7 in the retina shows an indistinguishable phenotype from knockout mice (PubMed:29100828). Electroretinogram (ERG) recordings show a significant and progressive reduction in response to light under scotopic (dark-adapted) and photopic (light-adapted) conditions (PubMed:29100828). Amplitude of both a-wave and b-wave responses is reduced indicating defects in both rod and cone type photoreceptors (PubMed:29100828). Sequence=BAC36832.1; Type=Erroneous initiation; Evidence=; microtubule cytoskeleton organization photoreceptor outer segment protein binding nucleoplasm cytoplasm mitochondrion cytosol cytoskeleton axoneme visual perception microtubule cytoskeleton photoreceptor connecting cilium ciliary basal body cell projection photoreceptor cell maintenance response to stimulus protein localization to photoreceptor outer segment protein localization to photoreceptor connecting cilium uc007ora.1 uc007ora.2 uc007ora.3 uc007ora.4 
ENSMUST00000048409.14 Elmod1 ENSMUST00000048409.14 ELMO/CED-12 domain containing 1, transcript variant 2 (from RefSeq NM_177769.5) ELMD1_MOUSE ENSMUST00000048409.1 ENSMUST00000048409.10 ENSMUST00000048409.11 ENSMUST00000048409.12 ENSMUST00000048409.13 ENSMUST00000048409.2 ENSMUST00000048409.3 ENSMUST00000048409.4 ENSMUST00000048409.5 ENSMUST00000048409.6 ENSMUST00000048409.7 ENSMUST00000048409.8 ENSMUST00000048409.9 NM_177769 Q3V1U8 uc009pmq.1 uc009pmq.2 Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Sequence=BAE21051.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; GTPase activator activity nucleoplasm cytosol positive regulation of GTPase activity uc009pmq.1 uc009pmq.2 
ENSMUST00000048418.14 Ipo8 ENSMUST00000048418.14 importin 8, transcript variant 4 (from RefSeq NM_001418296.1) B2KGD8 ENSMUST00000048418.1 ENSMUST00000048418.10 ENSMUST00000048418.11 ENSMUST00000048418.12 ENSMUST00000048418.13 ENSMUST00000048418.2 ENSMUST00000048418.3 ENSMUST00000048418.4 ENSMUST00000048418.5 ENSMUST00000048418.6 ENSMUST00000048418.7 ENSMUST00000048418.8 ENSMUST00000048418.9 IPO8_MOUSE Ipo8 NM_001418296 Q7TMY7 Q811I3 Q8C8A9 Q8R2P6 Q8R3V7 uc009etl.1 uc009etl.2 uc009etl.3 Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of the signal recognition particle protein SRP19. May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF- kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines. Forms a heterodimer with KPNB1. Interacts with SRP19. Interacts with RPL23A. Binds directly to nuclear pore complexes. Interacts with LRPPRC; the interaction occurs when LRPPRC is in its RNA-free form and promotes import of LRPPRC to the nucleus to allow for EIF4E-mediated export of mRNAS from the nucleus to the cytoplasm. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TMY7-1; Sequence=Displayed; Name=2; IsoId=Q7TMY7-2; Sequence=VSP_009656; Abundantly expressed in secretory and mature ameloblasts and weakly expressed in pre-ameloblasts of the lower incisor and molar at birth (at protein level). Knockout animals present with reduced grip strength and diminished vertical activity. Progressive dilatation can be observed in the aortic root at the level of the sinuses of Valsalva and distal ascending aorta, and aneurysms of the distal ascending aorta are becoming visible at the age of 8-12 weeks. Generally, males are more severely affected, exhibiting larger aortas and experiencing dissection and/or rupture more frequently than females. Belongs to the importin beta family. The regions from 407 to 653 were deduced from the genomic sequence and ESTs by similarity to the human sequence. nucleus nuclear envelope cytoplasm cytosol integral component of plasma membrane protein import into nucleus intracellular protein transport Ran GTPase binding protein transport ATPase activity, coupled to transmembrane movement of substances transmembrane transport uc009etl.1 uc009etl.2 uc009etl.3 
ENSMUST00000048421.14 Trappc14 ENSMUST00000048421.14 trafficking protein particle complex 14 (from RefSeq NM_153161.3) E9Q2V5 ENSMUST00000048421.1 ENSMUST00000048421.10 ENSMUST00000048421.11 ENSMUST00000048421.12 ENSMUST00000048421.13 ENSMUST00000048421.2 ENSMUST00000048421.3 ENSMUST00000048421.4 ENSMUST00000048421.5 ENSMUST00000048421.6 ENSMUST00000048421.7 ENSMUST00000048421.8 ENSMUST00000048421.9 Map11 NM_153161 Q3UTZ3 Q8JZV2 TPC14_MOUSE Trappc14 uc009aff.1 uc009aff.2 uc009aff.3 uc009aff.4 Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether. TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis. Modulates YAP1 activity as transcriptional regulator. Component of the multisubunit TRAPP II complex, which includes at least TRAPPC1, TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC4, TRAPPC5, TRAPPC6A/B, TRAPPC9, TRAPPC10 and TRAPPC14. TRAPPC9, TRAPPC10 and TRAPPC14 are specific subunits of the TRAPP II complex. Interacts with alpha-tubulin during mitosis. Interacts with RAB3IP (via the N-terminal region); this interaction mediates RAB3IP association with the TRAPP II complex. Interacts with TRAPPC10. Interacts with FBF1. Cytoplasm, cytoskeleton, spindle Vesicle Midbody Note=During mitosis, precedes alpha-tubulin in gap formation of cell abscission at the midbody and is co-localized with PLK1 at the edges of microtubules extensions of daughter cells post cytokinesis abscission. Colocalizes with RAB3IP on preciliary vesicles. Sequence=AAH37034.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cytoplasm microtubule organizing center spindle cytoskeleton plasma membrane midbody regulation of cell proliferation alpha-tubulin binding intracellular membrane-bounded organelle mitotic spindle uc009aff.1 uc009aff.2 uc009aff.3 uc009aff.4 
ENSMUST00000048427.9 Ankrd35 ENSMUST00000048427.9 ankyrin repeat domain 35, transcript variant 4 (from RefSeq NM_001356540.1) Ankrd35 E9Q9D8 E9Q9D8_MOUSE ENSMUST00000048427.1 ENSMUST00000048427.2 ENSMUST00000048427.3 ENSMUST00000048427.4 ENSMUST00000048427.5 ENSMUST00000048427.6 ENSMUST00000048427.7 ENSMUST00000048427.8 NM_001356540 uc008qns.1 uc008qns.2 uc008qns.3 molecular_function cellular_component biological_process uc008qns.1 uc008qns.2 uc008qns.3 
ENSMUST00000048430.4 Cer1 ENSMUST00000048430.4 cerberus 1, DAN family BMP antagonist (from RefSeq NM_009887.2) CER1_MOUSE Cerl Cerr1 ENSMUST00000048430.1 ENSMUST00000048430.2 ENSMUST00000048430.3 NM_009887 O35213 O55233 uc008tkl.1 uc008tkl.2 uc008tkl.3 uc008tkl.4 Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part, through a BMP- inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak. Forms monomers and predominantly dimers. Secreted At 6.5 dpc, early and mid-streak stage embryos, was expressed in the anterior visceral endoderm. The expression domain extended from the extraembryonic-embryonic junction to approximately two thirds of the way down the epiblast. By the mid-streak to late streak stage, expressed in the anterior visceral endoderm but was also expressed in the definitive endoderm emanating from the anterior portion of the primitive streak. By the neural plate stage at 7.5 dpc expression was present throughout the anterior definitive endoderm layer including both the midline and anterior lateral endoderm. At the early headfold stage expression was reduced in the anterior lateral region and expression was seen primarily in the foregut endoderm. In early 8.5 dpc embryos, expression was restricted to the two most recently formed somites. In 9 dpc and 9.5 dpc embryos, expression continued in the two newest formed somites and also in the anterior presomitic mesoderm. N-glycosylated. Belongs to the DAN family. ureteric bud development growth plate cartilage chondrocyte proliferation cytokine activity extracellular region extracellular space gastrulation nervous system development negative regulation of cell proliferation anterior/posterior axis specification anterior/posterior pattern specification morphogen activity signal transduction involved in regulation of gene expression bone mineralization negative regulation of BMP signaling pathway negative regulation of activin receptor signaling pathway sequestering of BMP in extracellular matrix BMP binding cell migration involved in gastrulation protein homodimerization activity determination of dorsal identity determination of heart left/right asymmetry cellular response to BMP stimulus negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry negative regulation of mesoderm development negative regulation of Wnt signaling pathway uc008tkl.1 uc008tkl.2 uc008tkl.3 uc008tkl.4 
ENSMUST00000048431.3 Naif1 ENSMUST00000048431.3 nuclear apoptosis inducing factor 1 (from RefSeq NM_194335.3) A2ASZ4 ENSMUST00000048431.1 ENSMUST00000048431.2 NAIF1_MOUSE NM_194335 Q6PFD7 Q8CEZ2 uc008jfr.1 uc008jfr.2 uc008jfr.3 Induces apoptosis. Interacts with HARBI1. Nucleus Belongs to the NAIF1 family. molecular_function nucleus nucleoplasm mitochondrion cytosol plasma membrane apoptotic process negative regulation of cell growth regulation of mitochondrial membrane permeability involved in apoptotic process uc008jfr.1 uc008jfr.2 uc008jfr.3 
ENSMUST00000048432.6 Prelp ENSMUST00000048432.6 proline arginine-rich end leucine-rich repeat (from RefSeq NM_054077.4) ENSMUST00000048432.1 ENSMUST00000048432.2 ENSMUST00000048432.3 ENSMUST00000048432.4 ENSMUST00000048432.5 NM_054077 PRELP_MOUSE Q9JK53 uc007crc.1 uc007crc.2 uc007crc.3 uc007crc.4 uc007crc.5 May anchor basement membranes to the underlying connective tissue. Binds the basement membrane heparan sulfate proteoglycan perlecan and triple helical collagens type I and type II. Secreted, extracellular space, extracellular matrix. Expressed in cartilage throughout both fetal development and postnatal life. It is also expressed in the developing embryo prior to skeletogenesis. In adult, highest expression in lung, lower levels in cardiac and skeletal muscle. The basic N-terminal Arg/Pro-rich binds heparin and heparan sulfate. Binds collagens type I and type II through its leucine-rich repeat domain. Glycosylated; contains heparan sulfate. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. extracellular matrix structural constituent extracellular region extracellular space cell aging heparin binding extracellular matrix structural constituent conferring compression resistance uc007crc.1 uc007crc.2 uc007crc.3 uc007crc.4 uc007crc.5 
ENSMUST00000048444.7 Klk5 ENSMUST00000048444.7 kallikrein related-peptidase 5 (from RefSeq NM_026806.2) ENSMUST00000048444.1 ENSMUST00000048444.2 ENSMUST00000048444.3 ENSMUST00000048444.4 ENSMUST00000048444.5 ENSMUST00000048444.6 Klk5 Klnc NM_026806 Q9D140 Q9D140_MOUSE uc009gnx.1 uc009gnx.2 positive regulation of antibacterial peptide production serine-type endopeptidase activity extracellular region extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity extracellular matrix disassembly secretory granule positive regulation of G-protein coupled receptor protein signaling pathway amelogenesis epidermal lamellar body uc009gnx.1 uc009gnx.2 
ENSMUST00000048452.6 Plvap ENSMUST00000048452.6 plasmalemma vesicle associated protein (from RefSeq NM_032398.2) ENSMUST00000048452.1 ENSMUST00000048452.2 ENSMUST00000048452.3 ENSMUST00000048452.4 ENSMUST00000048452.5 G3X924 G3X924_MOUSE NM_032398 Plvap uc009mdp.1 uc009mdp.2 uc009mdp.3 uc009mdp.4 MAPK cascade positive regulation of cellular extravasation caveola cell surface membrane integral component of membrane tumor necrosis factor-mediated signaling pathway protein homodimerization activity uc009mdp.1 uc009mdp.2 uc009mdp.3 uc009mdp.4 
ENSMUST00000048459.8 5530400C23Rik ENSMUST00000048459.8 RIKEN cDNA 5530400C23 gene (from RefSeq NM_027784.1) 5530400C23Rik ENSMUST00000048459.1 ENSMUST00000048459.2 ENSMUST00000048459.3 ENSMUST00000048459.4 ENSMUST00000048459.5 ENSMUST00000048459.6 ENSMUST00000048459.7 NM_027784 Q9D3I0 Q9D3I0_MOUSE uc009eka.1 uc009eka.2 uc009eka.3 molecular_function cellular_component biological_process uc009eka.1 uc009eka.2 uc009eka.3 
ENSMUST00000048462.13 Mtarc1 ENSMUST00000048462.13 mitochondrial amidoxime reducing component 1 (from RefSeq NM_001290273.1) ENSMUST00000048462.1 ENSMUST00000048462.10 ENSMUST00000048462.11 ENSMUST00000048462.12 ENSMUST00000048462.2 ENSMUST00000048462.3 ENSMUST00000048462.4 ENSMUST00000048462.5 ENSMUST00000048462.6 ENSMUST00000048462.7 ENSMUST00000048462.8 ENSMUST00000048462.9 MARC1_MOUSE Marc1 Mosc1 NM_001290273 Q8R2L6 Q9CW42 uc007dyp.1 uc007dyp.2 uc007dyp.3 uc007dyp.4 Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L- arginine = 2 Fe(III)-[cytochrome b5] + H2O + L-arginine; Xref=Rhea:RHEA:61644, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:32682, ChEBI:CHEBI:60107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61645; Evidence=; Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Evidence=; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. ; Component of a complex composed of cytochrome b5, NADH- cytochrome b5 reductase and MTARC1. Mitochondrion outer membrane ; Single-pass type II membrane protein Membrane ; Lipid-anchor Note=Mitochondrial import is mediated by AA 1-40 and requires ATP. Comprises two structural domains, the molybdenum cofactor/Moco sulfurase C-terminal (MOSC) domain and the MOSC N-terminal region, forming a cleft that accommodates Moco. The MOSC domain, which contains a large seven-stranded mostly antiparallel beta-barrel, engages multiple interactions with Moco both pterin ring and phosphate group, allowing for a tight coordination of Moco within the core of the enzyme. Sequence=AAH28441.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB23724.1; Type=Frameshift; Evidence=; catalytic activity mitochondrion mitochondrial outer membrane mitochondrial inner membrane nitrate reductase activity membrane integral component of membrane oxidoreductase activity molybdenum ion binding pyridoxal phosphate binding nitrate metabolic process molybdopterin cofactor binding oxidation-reduction process uc007dyp.1 uc007dyp.2 uc007dyp.3 uc007dyp.4 
ENSMUST00000048471.15 Abi3bp ENSMUST00000048471.15 ABI family member 3 binding protein, transcript variant 5 (from RefSeq NM_001014423.2) Abi3bp ENSMUST00000048471.1 ENSMUST00000048471.10 ENSMUST00000048471.11 ENSMUST00000048471.12 ENSMUST00000048471.13 ENSMUST00000048471.14 ENSMUST00000048471.2 ENSMUST00000048471.3 ENSMUST00000048471.4 ENSMUST00000048471.5 ENSMUST00000048471.6 ENSMUST00000048471.7 ENSMUST00000048471.8 ENSMUST00000048471.9 NM_001014423 Q59IW6 Q59IW6_MOUSE TARSH uc007zmq.1 uc007zmq.2 uc007zmq.3 uc007zmq.4 extracellular matrix structural constituent collagen binding glycosaminoglycan binding interstitial matrix heparin binding positive regulation of cell-substrate adhesion extracellular matrix organization extracellular matrix uc007zmq.1 uc007zmq.2 uc007zmq.3 uc007zmq.4 
ENSMUST00000048479.14 Cd200r3 ENSMUST00000048479.14 According to PubMed:15187158 isoform 4 is a receptor for the CD200 cell surface glycoprotein. According to PubMed:16081818 isoform 4 is not a receptor for the CD200/OX2 cell surface glycoprotein. Isoform 1, isoform 2 and isoform 3 are involved in the recruitment or surface expression of the TYROBP receptor. Isoform 6, isoform 7 and isoform 8 are not involved in the recruitment or surface expression of the TYROBP receptor. (from UniProt Q5UKY4) AK040868 Cd200rlb ENSMUST00000048479.1 ENSMUST00000048479.10 ENSMUST00000048479.11 ENSMUST00000048479.12 ENSMUST00000048479.13 ENSMUST00000048479.2 ENSMUST00000048479.3 ENSMUST00000048479.4 ENSMUST00000048479.5 ENSMUST00000048479.6 ENSMUST00000048479.7 ENSMUST00000048479.8 ENSMUST00000048479.9 MO2R3_MOUSE Q3V3F9 Q5UKY1 Q5UKY2 Q5UKY3 Q5UKY4 Q5UKY5 Q6XJV5 Q9D628 Q9D642 uc007zhz.1 uc007zhz.2 uc007zhz.3 According to PubMed:15187158 isoform 4 is a receptor for the CD200 cell surface glycoprotein. According to PubMed:16081818 isoform 4 is not a receptor for the CD200/OX2 cell surface glycoprotein. Isoform 1, isoform 2 and isoform 3 are involved in the recruitment or surface expression of the TYROBP receptor. Isoform 6, isoform 7 and isoform 8 are not involved in the recruitment or surface expression of the TYROBP receptor. Isoform 3 interacts with TYROBP. Isoform 8 does not interact with TYROBP. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=9; Name=1; Synonyms=Cd200r3b; IsoId=Q5UKY4-1; Sequence=Displayed; Name=2; Synonyms=Cd200r3a; IsoId=Q5UKY4-2; Sequence=VSP_035006; Name=3; Synonyms=Cd200r3c; IsoId=Q5UKY4-3; Sequence=VSP_035007; Name=4; IsoId=Q5UKY4-4; Sequence=VSP_035008; Name=5; IsoId=Q5UKY4-5; Sequence=VSP_035004, VSP_035005; Name=6; Synonyms=Cd200r3e; IsoId=Q5UKY4-6; Sequence=VSP_035003; Name=7; Synonyms=Cd200r3d; IsoId=Q5UKY4-7; Sequence=VSP_035003, VSP_035006; Name=8; Synonyms=Cd200r3f; IsoId=Q5UKY4-8; Sequence=VSP_035003, VSP_035007; Name=9; IsoId=Q5UKY4-9; Sequence=VSP_035003, VSP_035008; Expressed in uterus and bone marrow-derived mast cells (at protein level). Expressed in uterus, spleen, bone marrow- derived dendritic, basophil and mast cells. Expressed in the lung of N.brasiliensis-infected mice. Weakly expressed in brain, testis, lung and thymus. Expressed in uterus at 12.5 dpc (at protein level). Belongs to the CD200R family. According to some authors, isoform 3 (truncated at the N- terminus) is not a receptor for the CD200/OX2 cell surface glycoprotein. protein binding external side of plasma membrane membrane integral component of membrane signaling receptor activity uc007zhz.1 uc007zhz.2 uc007zhz.3 
ENSMUST00000048482.8 2010003K11Rik ENSMUST00000048482.8 RIKEN cDNA 2010003K11 gene (from RefSeq NM_027237.2) CK086_MOUSE ENSMUST00000048482.1 ENSMUST00000048482.2 ENSMUST00000048482.3 ENSMUST00000048482.4 ENSMUST00000048482.5 ENSMUST00000048482.6 ENSMUST00000048482.7 NM_027237 Q8VC23 Q9D8F7 uc008gae.1 uc008gae.2 uc008gae.3 uc008gae.4 molecular_function cellular_component biological_process uc008gae.1 uc008gae.2 uc008gae.3 uc008gae.4 
ENSMUST00000048485.7 Sln ENSMUST00000048485.7 sarcolipin (from RefSeq NM_025540.2) ENSMUST00000048485.1 ENSMUST00000048485.2 ENSMUST00000048485.3 ENSMUST00000048485.4 ENSMUST00000048485.5 ENSMUST00000048485.6 NM_025540 Q9CQD6 SARCO_MOUSE Sln uc009pmp.1 uc009pmp.2 uc009pmp.3 Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA460968.1, CB596554.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Reversibly inhibits the activity of ATP2A1 and ATP2A2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle (PubMed:21697544, PubMed:26816378). Required for muscle-based, non- shivering thermogenesis (PubMed:22961106). Interacts with calcium ATPase ATP2A1/SERCA1. Interact with ATP2A2; the inhibition decreases ATP2A1 Ca(2+) affinity. Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2 (By similarity). Sarcoplasmic reticulum membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Highly expressed in heart atrium, red gastrocnemius muscle and soleus. Detected at lower levels in the extensor digitorum longus muscle (at protein level). No visible phenotype at 22 degrees Celsius. Increased heat-loss and failure to maintain body temperature at 4 degrees Celsius when the shivering response is prevented. Mice show increased weight gain and obesity when kept on a high-fat diet. Mice display faster muscle relaxation rates in soleus due to an increase in the affinity of ATP2A1 for Ca(2+). Belongs to the sarcolipin family. protein binding endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane sarcoplasmic reticulum enzyme regulator activity sarcoplasmic reticulum membrane regulation of catalytic activity regulation of calcium ion transport sarcoplasmic reticulum calcium ion transport regulation of relaxation of muscle negative regulation of calcium ion binding regulation of calcium-transporting ATPase activity negative regulation of calcium-transporting ATPase activity uc009pmp.1 uc009pmp.2 uc009pmp.3 
ENSMUST00000048486.13 Fgg ENSMUST00000048486.13 fibrinogen gamma chain, transcript variant 1 (from RefSeq NM_133862.2) ENSMUST00000048486.1 ENSMUST00000048486.10 ENSMUST00000048486.11 ENSMUST00000048486.12 ENSMUST00000048486.2 ENSMUST00000048486.3 ENSMUST00000048486.4 ENSMUST00000048486.5 ENSMUST00000048486.6 ENSMUST00000048486.7 ENSMUST00000048486.8 ENSMUST00000048486.9 FIBG_MOUSE NM_133862 Q8VCM7 Q8WUR3 Q91ZP0 uc008ppe.1 uc008ppe.2 uc008ppe.3 uc008ppe.4 This gene encodes the gamma subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Mice lacking the encoded protein did not possess detectable amounts of plasma fibrinogen. Pregnant mice lacking the encoded protein die due to heavy bleeding during delivery. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]. Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (By similarity). Fibrin has a major function in hemostasis as one of the primary components of blood clots (By similarity). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (By similarity). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (By similarity). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (By similarity). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (By similarity). May also facilitate the immune response via both innate and T-cell mediated pathways (By similarity). Heterohexamer; disulfide linked. Contains 2 sets of 3 non- identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity). Secreted A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure. Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers (By similarity). adaptive immune response immune system process receptor binding structural molecule activity extracellular matrix structural constituent extracellular region fibrinogen complex extracellular space cytoplasm cell cortex cell-matrix adhesion blood coagulation hemostasis protein secretion external side of plasma membrane cell surface platelet activation platelet alpha granule plasminogen activation positive regulation of heterotypic cell-cell adhesion cellular macromolecular complex assembly fibrinolysis protein homodimerization activity innate immune response synapse positive regulation of vasoconstriction positive regulation of exocytosis metal ion binding positive regulation of protein secretion cell adhesion molecule binding protein polymerization response to calcium ion positive regulation of ERK1 and ERK2 cascade platelet aggregation blood coagulation, fibrin clot formation blood microparticle positive regulation of peptide hormone secretion negative regulation of platelet aggregation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of endothelial cell apoptotic process uc008ppe.1 uc008ppe.2 uc008ppe.3 uc008ppe.4 
ENSMUST00000048514.11 Nlrp1a ENSMUST00000048514.11 Acts as the sensor component of the Nlrp1a inflammasome, which mediates inflammasome activation in response to various pathogen- associated signals, leading to subsequent pyroptosis (PubMed:23219391). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (By similarity). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, and mediates the formation of the inflammasome polymeric complex (By similarity). In response to pathogen-associated signals, the N-terminal part of Nlrp1a is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1a, C-terminus), which polymerizes to initiate the formation of the inflammasome complex: the inflammasome recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (By similarity). In the absence of GSDMD expression, the Nlrp1a inflammasome is able to recruit and activate CASP8, leading to activation of gasdermin-E (GSDME) (By similarity). Activation of Nlrp1a inflammasome is also required for HMGB1 secretion; the active cytokines and HMGB1 stimulate inflammatory responses (By similarity). When activated in the bone marrow, induces the pyroptosis of hematopoietic stem cells and progenitor cells of both myeloid and lymphoid lineages, hence allowing the removal of damaged cells, and the release of IL1B, which induces granulopoiesis (PubMed:23219391). (from UniProt Q2LKU9) AY355339 Card7 ENSMUST00000048514.1 ENSMUST00000048514.10 ENSMUST00000048514.2 ENSMUST00000048514.3 ENSMUST00000048514.4 ENSMUST00000048514.5 ENSMUST00000048514.6 ENSMUST00000048514.7 ENSMUST00000048514.8 ENSMUST00000048514.9 M4T3K8 M4T4C8 M4T632 M4TJP5 NLR1A_MOUSE Nalp1 Nalp1a Nlrp1 Nlrp1a Q2LKU9 Q3U0B5 Q67EY4 uc011xye.1 uc011xye.2 uc011xye.3 Acts as the sensor component of the Nlrp1a inflammasome, which mediates inflammasome activation in response to various pathogen- associated signals, leading to subsequent pyroptosis (PubMed:23219391). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (By similarity). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, and mediates the formation of the inflammasome polymeric complex (By similarity). In response to pathogen-associated signals, the N-terminal part of Nlrp1a is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1a, C-terminus), which polymerizes to initiate the formation of the inflammasome complex: the inflammasome recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (By similarity). In the absence of GSDMD expression, the Nlrp1a inflammasome is able to recruit and activate CASP8, leading to activation of gasdermin-E (GSDME) (By similarity). Activation of Nlrp1a inflammasome is also required for HMGB1 secretion; the active cytokines and HMGB1 stimulate inflammatory responses (By similarity). When activated in the bone marrow, induces the pyroptosis of hematopoietic stem cells and progenitor cells of both myeloid and lymphoid lineages, hence allowing the removal of damaged cells, and the release of IL1B, which induces granulopoiesis (PubMed:23219391). [NACHT, LRR and PYD domains-containing protein 1a]: Constitutes the precursor of the Nlrp1a inflammasome, which mediates autoproteolytic processing within the FIIND domain to generate the N- terminal and C-terminal parts, which are associated non-covalently in absence of pathogens and other damage-associated signals. [NACHT, LRR and PYD domains-containing protein 1a, N- terminus]: Regulatory part that prevents formation of the Nlrp1a inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of Nlrp1a (NACHT, LRR and PYD domains-containing protein 1a, C-terminus), preventing activation of the Nlrp1a inflammasome (By similarity). In response to pathogen- associated signals, this part is ubiquitinated and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the Nlrp1a inflammasome (By similarity). [NACHT, LRR and PYD domains-containing protein 1a, C- terminus]: Constitutes the active part of the Nlrp1a inflammasome (By similarity). In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of Nlrp1a (NACHT, LRR and PYD domains-containing protein 1a, N-terminus), preventing activation of the Nlrp1a inflammasome (By similarity). In response to pathogen- associated signals, the N-terminal part of Nlrp1a is degraded by the proteasome, releasing this form, which polymerizes to form the Nlrp1a inflammasome complex: the Nlrp1a inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis (By similarity). Nlrp1a inflammasome is activated by pathogens and other damage-associated signals: activation promotes ubiquitination and degradation of the N-terminal part, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1a, C-terminus), which polymerizes and forms the Nlrp1a inflammasome (By similarity). Nlrp1a inflammasome is inhibited by DPP8 and DPP9, which sequester the C-terminal fragment of Nlrp1a (NACHT, LRR and PYD domains-containing protein 1a, C-terminus) in a ternary complex, thereby preventing Nlrp1a oligomerization and activation (By similarity). Nlrp1a inflammasome is activated by Val-boroPro (Talabostat, PT-100), an inhibitor of dipeptidyl peptidases DPP8 and DPP9 (PubMed:31383852). Val-boroPro relieves inhibition of DPP8 and/or DPP9 by promoting disruption of the ternary complex, releasing its C- terminal part from autoinhibition (By similarity). Interacts (via LRR repeats) with BCL2 and BCL2L1 (via the loop between motifs BH4 and BH3) (By similarity). Interacts with NOD2; this interaction is enhanced in the presence of muramyl dipeptide (MDP) and increases IL1B release (By similarity). Interacts with EIF2AK2/PKR; this interaction requires EIF2AK2 activity, is accompanied by EIF2AK2 autophosphorylation and promotes inflammasome assembly in response to danger-associated signals (By similarity). Interacts with MEFV; this interaction targets Nlrp1a to degradation by autophagy, hence preventing excessive IL1B- and IL18-mediated inflammation (By similarity). Interacts with DPP9; leading to inhibit activation of the inflammasome (By similarity). DPP9 acts via formation of a ternary complex, composed of a DPP9 homodimer, one full-length Nlrp1a protein, and one cleaved C-terminus of Nlrp1a (NACHT, LRR and PYD domains- containing protein 1a, C-terminus) (By similarity). Interacts with DPP8; leading to inhibit activation of the inflammasome, probably via formation of a ternary complex with DPP8 (By similarity). [NACHT, LRR and PYD domains-containing protein 1a, N- terminus]: Interacts with the C-terminal part of Nlrp1a (NACHT, LRR and PYD domains-containing protein 1a, C-terminus) in absence of pathogens and other damage-associated signals. [NACHT, LRR and PYD domains-containing protein 1a, C- terminus]: Interacts with the N-terminal part of Nlrp1a (NACHT, LRR and PYD domains-containing protein 1a, N-terminus) in absence of pathogens and other damage-associated signals (By similarity). Homomultimer; forms the Nlrp1a inflammasome polymeric complex, a filament composed of homopolymers of this form in response to pathogens and other damage- associated signals (By similarity). Interacts (via CARD domain) with CASP1 (via CARD domain); leading to CASP1 activation (By similarity). Cytoplasm, cytosol Cytoplasm Nucleus Note=Nucleocytoplasmic distribution in lymphoid organs (probably in T- cells) and in neurons. In epithelial cells, predominantly cytoplasmic. [NACHT, LRR and PYD domains-containing protein 1a, C-terminus]: Inflammasome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2LKU9-1; Sequence=Displayed; Name=2; IsoId=Q2LKU9-2; Sequence=VSP_058002, VSP_058003, VSP_058004; Highly expressed in hematopoietic stem cells and progenitor cells of both myeloid and lymphoid origin (PubMed:23219391). The expression is highly strain-dependent. Not expressed in Balb/cJ animals, but widely expressed in C57BL/6J. Expressed in macrophages resistant to Bacillus anthracis lethal toxin, but not in toxin- sensitive macrophages, except in CAST/EiJ strain (PubMed:23506131). The leucine-rich repeat (LRR) domain may be involved in autoinhibition in the absence of activating signal, possibly through intramolecular interaction with the NACHT domain. The FIIND (domain with function to find) region is involved in homomerization, but not in CASP1-binding. Autocatalytic cleavage in this region occurs constitutively, prior to activation signals, and is required for inflammasome activity (IL1B release), possibly by facilitating CASP1 binding. Both N- and C-terminal fragments remain associated. [NACHT, LRR and PYD domains-containing protein 1a, C-terminus]: The C-terminal part of Nlrp1a oligomerizes to form the core of the Nlrp1a inflammasome filament: in the filament, the CARD domains form a central helical filaments that are promoted by oligomerized, but flexibly linked, UPA regions surrounding the filaments. The UPA region reduces the threshold needed for filament formation and signaling. [NACHT, LRR and PYD domains-containing protein 1a]: Autocatalytically cleaved. Autocatalytic cleavage in FIIND region occurs constitutively, prior to activation signals, and is required for inflammasome activity (IL1B release), possibly by facilitating CASP1 binding. Both N- and C-terminal parts remain associated non-covalently. [NACHT, LRR and PYD domains-containing protein 1a, N-terminus]: Ubiquitinated in response to pathogen-associated signals, leading to its degradation by the proteasome and subsequent release of the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1a, C-terminus), which polymerizes and forms the Nlrp1a inflammasome. Three tandem Nrlp1 paralogs, Nrlp1a, Nrlp1b and Nrlp1c, are present in at least 2 strains, C57BL/6J and 129S1/SvImJ. Nlrp1c is predicted to be a pseudogene. Nlrp1b is the primary mediator of macrophage susceptibility to Bacillus anthracis lethal toxin (LT). Neither Nlrp1a, nor Nrlp1c are expressed in anthrax lethal toxin susceptible strains, hence neither of them is thought to play an important role in this phenotype. Belongs to the NLRP family. nucleotide binding protein binding ATP binding nucleus cytoplasm cytosol activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response enzyme binding response to muramyl dipeptide macromolecular complex defense response to bacterium regulation of apoptotic process neuronal cell body positive regulation of cysteine-type endopeptidase activity involved in apoptotic process innate immune response positive regulation of interleukin-1 beta secretion neuron apoptotic process inflammasome complex scaffold protein binding programmed necrotic cell death uc011xye.1 uc011xye.2 uc011xye.3 
ENSMUST00000048518.16 Parpbp ENSMUST00000048518.16 PARP1 binding protein (from RefSeq NM_029249.2) A0A0R4J0G5 A0A0R4J0G5_MOUSE ENSMUST00000048518.1 ENSMUST00000048518.10 ENSMUST00000048518.11 ENSMUST00000048518.12 ENSMUST00000048518.13 ENSMUST00000048518.14 ENSMUST00000048518.15 ENSMUST00000048518.2 ENSMUST00000048518.3 ENSMUST00000048518.4 ENSMUST00000048518.5 ENSMUST00000048518.6 ENSMUST00000048518.7 ENSMUST00000048518.8 ENSMUST00000048518.9 NM_029249 Parpbp uc007grd.1 uc007grd.2 uc007grd.3 Cytoplasm Nucleus Belongs to the PARI family. nucleoplasm negative regulation of double-strand break repair via homologous recombination uc007grd.1 uc007grd.2 uc007grd.3 
ENSMUST00000048519.17 Snx13 ENSMUST00000048519.17 sorting nexin 13, transcript variant 12 (from RefSeq NM_001408825.1) ENSMUST00000048519.1 ENSMUST00000048519.10 ENSMUST00000048519.11 ENSMUST00000048519.12 ENSMUST00000048519.13 ENSMUST00000048519.14 ENSMUST00000048519.15 ENSMUST00000048519.16 ENSMUST00000048519.2 ENSMUST00000048519.3 ENSMUST00000048519.4 ENSMUST00000048519.5 ENSMUST00000048519.6 ENSMUST00000048519.7 ENSMUST00000048519.8 ENSMUST00000048519.9 NM_001408825 Q6PHS6 SNX13_MOUSE uc007njg.1 uc007njg.2 uc007njg.3 uc007njg.4 May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis. Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate. Embryonic lethal. After 8.5 dpc, embryos are smaller, show failure of neural tube closure and abnormal cephalic vascularization. None survive after 14.5 dpc. Visceral yolk sac endoderm cells contain large autophagic vacuoles. Belongs to the sorting nexin family. endosome early endosome intracellular protein transport lipid binding negative regulation of signal transduction protein transport membrane early endosome membrane phosphatidylinositol-3-phosphate binding phosphatidylinositol binding positive regulation of GTPase activity uc007njg.1 uc007njg.2 uc007njg.3 uc007njg.4 
ENSMUST00000048544.14 Bicd2 ENSMUST00000048544.14 BICD cargo adaptor 2, transcript variant 1 (from RefSeq NM_001039179.2) BICD2_MOUSE ENSMUST00000048544.1 ENSMUST00000048544.10 ENSMUST00000048544.11 ENSMUST00000048544.12 ENSMUST00000048544.13 ENSMUST00000048544.2 ENSMUST00000048544.3 ENSMUST00000048544.4 ENSMUST00000048544.5 ENSMUST00000048544.6 ENSMUST00000048544.7 ENSMUST00000048544.8 ENSMUST00000048544.9 Kiaa0699 NM_001039179 Q80TU1 Q8BTE3 Q921C5 Q9DCL3 uc007qji.1 uc007qji.2 uc007qji.3 uc007qji.4 Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:11483508, PubMed:25035494, PubMed:24986880, PubMed:22956769). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form (PubMed:25962623). Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:12447383, PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (PubMed:20386726). Part of a tripartite complex with dynein and dynactin, acts an adapter linking the dynein motor complex and dynactin (By similarity). Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Interacts with NEK9 (By similarity). Interacts with DCTN2 (PubMed:11483508, PubMed:22956769). Interacts with RAB6A (PubMed:12447383, PubMed:25962623). Interacts with DNAI1 (By similarity). Interacts with DYNLL1, DYNC1H1, DYNC1I2 and DCTN1 (PubMed:22956769). Forms a complex with dynein and dynactin (PubMed:24986880). The dynein-dynactin-BICD2 ternary complex (DDB) binds preferentially to tyrosinated microtubules than to detyrosinated microtubules (PubMed:26968983). Interacts with RANBP2, RAB6A and KIF5A (PubMed:20386726). Interacts with KIF1C (By similarity). Q921C5; P35279: Rab6a; NbExp=3; IntAct=EBI-642984, EBI-444674; Q921C5-1; P49792: RANBP2; Xeno; NbExp=4; IntAct=EBI-642995, EBI-973138; Golgi apparatus toplasm, cytoskeleton Cytoplasm Nucleus, nuclear pore complex Nucleus envelope Note=In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (PubMed:11483508). Localizes to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae in a RANBP2-dependent manner during G2 phase of the cell cycle (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q921C5-1; Sequence=Displayed; Name=2; IsoId=Q921C5-2; Sequence=VSP_007970; Name=3; IsoId=Q921C5-3; Sequence=VSP_007971, VSP_007972; Ubiquitously expressed with high expression in the spinal cord. The fourth coiled coil region is involved in Golgi targeting and in the interaction with DCTN2. Phosphorylated by NEK9 in vitro. Belongs to the BicD family. Sequence=BAC65630.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; [Isoform 3]: Sequence=BAB22282.1; Type=Frameshift; Evidence=; protein binding nucleus nuclear envelope annulate lamellae nuclear pore cytoplasm Golgi apparatus centrosome cytosol cytoskeleton plasma membrane retrograde vesicle-mediated transport, Golgi to ER microtubule-based movement cytoskeletal adaptor activity protein transport Rab GTPase binding cytoplasmic vesicle protein localization to Golgi apparatus dynactin binding mRNA transport centrosome localization dynein light intermediate chain binding regulation of microtubule cytoskeleton organization dynein complex binding minus-end-directed organelle transport along microtubule microtubule anchoring at microtubule organizing center uc007qji.1 uc007qji.2 uc007qji.3 uc007qji.4 
ENSMUST00000048545.10 Arglu1 ENSMUST00000048545.10 arginine and glutamate rich 1 (from RefSeq NM_176849.3) ARGL1_MOUSE ENSMUST00000048545.1 ENSMUST00000048545.2 ENSMUST00000048545.3 ENSMUST00000048545.4 ENSMUST00000048545.5 ENSMUST00000048545.6 ENSMUST00000048545.7 ENSMUST00000048545.8 ENSMUST00000048545.9 NM_176849 Q3UL36 Q80XJ0 uc009kug.1 uc009kug.2 uc009kug.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UL36-1; Sequence=Displayed; Name=2; IsoId=Q3UL36-2; Sequence=VSP_025675, VSP_025676; Belongs to the UPF0430 family. Sequence=BAE26615.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence=; nucleoplasm mitochondrion uc009kug.1 uc009kug.2 uc009kug.3 
ENSMUST00000048557.3 Npffr2 ENSMUST00000048557.3 neuropeptide FF receptor 2, transcript variant 2 (from RefSeq NM_133192.4) ENSMUST00000048557.1 ENSMUST00000048557.2 Gpr74 NM_133192 NPFF2_MOUSE Npff2 Q8BKR6 Q924H0 uc008yan.1 uc008yan.2 Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway neuropeptide receptor activity actin cytoskeleton membrane integral component of membrane opioid receptor binding cellular response to hormone stimulus regulation of MAPK cascade regulation of adenylate cyclase activity regulation of cAMP-dependent protein kinase activity uc008yan.1 uc008yan.2 
ENSMUST00000048560.11 Kank3 ENSMUST00000048560.11 KN motif and ankyrin repeat domains 3, transcript variant 1 (from RefSeq NM_030697.3) Ankrd47 D17Ertd288e ENSMUST00000048560.1 ENSMUST00000048560.10 ENSMUST00000048560.2 ENSMUST00000048560.3 ENSMUST00000048560.4 ENSMUST00000048560.5 ENSMUST00000048560.6 ENSMUST00000048560.7 ENSMUST00000048560.8 ENSMUST00000048560.9 KANK3_MOUSE Kank3 NM_030697 Ng28 Q9Z1P7 uc008bzq.1 uc008bzq.2 uc008bzq.3 May be involved in the control of cytoskeleton formation by regulating actin polymerization. molecular_function cytoplasm negative regulation of actin filament polymerization negative regulation of stress fiber assembly uc008bzq.1 uc008bzq.2 uc008bzq.3 
ENSMUST00000048565.9 Trim60 ENSMUST00000048565.9 tripartite motif-containing 60 (from RefSeq NM_153097.2) 2czf45 ENSMUST00000048565.1 ENSMUST00000048565.2 ENSMUST00000048565.3 ENSMUST00000048565.4 ENSMUST00000048565.5 ENSMUST00000048565.6 ENSMUST00000048565.7 ENSMUST00000048565.8 NM_153097 Q3UX74 Q8VI40 Rnf33 TRI60_MOUSE uc009lve.1 uc009lve.2 uc009lve.3 uc009lve.4 E3 SUMO-protein ligase that mediates SUMOylation of TAB2 leading to inhibition of NF-kappa-B and MAPK pathways by suppressing the TRAF6/TAB2/TAK1 complex. Q8VI40; P28741: Kif3a; NbExp=5; IntAct=EBI-6395249, EBI-6169413; Q8VI40; Q61771: Kif3b; NbExp=3; IntAct=EBI-6395249, EBI-6395332; Expressed exclusively in embryos before or up to the 8-cell stage. TRIM60-deficient mice show an elevated immune response to LPS-induced septic shock and L. monocytogenes infection. Belongs to the TRIM/RBCC family. protein binding biological_process zinc ion binding metal ion binding uc009lve.1 uc009lve.2 uc009lve.3 uc009lve.4 
ENSMUST00000048568.6 Inka1 ENSMUST00000048568.6 inka box actin regulator 1 (from RefSeq NM_026597.4) ENSMUST00000048568.1 ENSMUST00000048568.2 ENSMUST00000048568.3 ENSMUST00000048568.4 ENSMUST00000048568.5 Fam212a INKA1_MOUSE Inka1 NM_026597 Q08EG3 Q80WB2 Q8BPE9 Q9CX62 uc009rnv.1 uc009rnv.2 uc009rnv.3 uc009rnv.4 uc009rnv.5 Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity. Interacts with PAK4 (PubMed:17314132). Nucleus Cytoplasm Note=Mainly nuclear. Relocalizes to the cytoplasm following interaction with PAK4. Expressed in tissues of the developing head during neurulation. Expressed in the cephalic mesenchyme, heart and paraxial mesoderm prior to 8.5 dpc. Expression is then observed in the migratory neural crest cells and their derivatives. As development progresses, expression is also observed in the limb buds and perichondrial tissue. Contains 2 Inka boxes (also named iBox or inca box). The Inka boxes bind and inhibit PAK4 by binding a substrate-like manner. No visible phenotype in most cases: most mice are viable and fertile. A low percentage of mice show exencephaly. Expression of Inka1 is not regulated by AP-2- alpha/Tfap2a, as it is the case for orthologous protein in zebrafish and Xenopus. Belongs to the INKA family. nucleus cytoplasm protein kinase binding neural tube development protein serine/threonine kinase inhibitor activity negative regulation of protein serine/threonine kinase activity uc009rnv.1 uc009rnv.2 uc009rnv.3 uc009rnv.4 uc009rnv.5 
ENSMUST00000048572.7 Hlx ENSMUST00000048572.7 H2.0-like homeobox (from RefSeq NM_008250.2) ENSMUST00000048572.1 ENSMUST00000048572.2 ENSMUST00000048572.3 ENSMUST00000048572.4 ENSMUST00000048572.5 ENSMUST00000048572.6 HLX_MOUSE Hlx1 NM_008250 Q61670 uc007dyn.1 uc007dyn.2 uc007dyn.3 uc007dyn.4 uc007dyn.5 Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis. Nucleus Expressed in Th1 cells, CD8-positive T-cells, B- cells and NK cells. By TBX21 in developing as well as mature Th1 cells. Th1 cells lacking Hlx or Tbx21 fail to express normal levels of the Th1-specific cytokine Ifng. Belongs to the H2.0 homeobox family. liver development DNA binding nucleus regulation of transcription, DNA-templated skeletal muscle tissue development positive regulation of cell proliferation cell differentiation sequence-specific DNA binding positive regulation of T-helper 1 cell differentiation negative regulation of T-helper 2 cell differentiation positive regulation of organ growth enteric nervous system development animal organ development embryonic digestive tract morphogenesis uc007dyn.1 uc007dyn.2 uc007dyn.3 uc007dyn.4 uc007dyn.5 
ENSMUST00000048578.3 Ttc1 ENSMUST00000048578.3 tetratricopeptide repeat domain 1 (from RefSeq NM_133795.2) ENSMUST00000048578.1 ENSMUST00000048578.2 NM_133795 Q3TLM0 Q91Z38 TTC1_MOUSE uc007imx.1 uc007imx.2 uc007imx.3 Interacts with the GAP domain of NF1. Interacts (via TPR repeats) with HSP90AA1 and HSPA8. molecular_function cytosol biological_process uc007imx.1 uc007imx.2 uc007imx.3 
ENSMUST00000048580.2 Tsga13 ENSMUST00000048580.2 testis specific gene A13 (from RefSeq NM_054073.2) ENSMUST00000048580.1 NM_054073 Q9DA17 TSG13_MOUSE uc009bfx.1 uc009bfx.2 molecular_function cellular_component uc009bfx.1 uc009bfx.2 
ENSMUST00000048603.8 Dnah1 ENSMUST00000048603.8 dynein, axonemal, heavy chain 1 (from RefSeq NM_001033668.1) DYH1_MOUSE Dhc7 Dnah1 Dnahc1 E9Q8T7 ENSMUST00000048603.1 ENSMUST00000048603.2 ENSMUST00000048603.3 ENSMUST00000048603.4 ENSMUST00000048603.5 ENSMUST00000048603.6 ENSMUST00000048603.7 NM_001033668 O08828 Q8R584 uc007sxk.1 uc007sxk.2 uc007sxk.3 Force generating protein of cilia required for sperm flagellum motility (PubMed:11371505). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (By similarity). Consists of at least two heavy chains and a number of intermediate and light chains. Cytoplasm, cytoskeleton, cilium axoneme Cell projection, cilium, flagellum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q8T7-1; Sequence=Displayed; Name=2; IsoId=E9Q8T7-2; Sequence=VSP_059235, VSP_059236; Mice are viable and show no malformations; however, homozygous males are infertile, due to inability of spermatozoa to move from the uterus into the oviduct. Spermatozoa show decreased motility. In addition, tracheal beating frequency is reduced. Belongs to the dynein heavy chain family. nucleotide binding cilium movement epithelial cilium movement motor activity microtubule motor activity ATP binding extracellular region cytoplasm cytoskeleton axonemal dynein complex microtubule cilium axoneme microtubule-based movement sperm axoneme assembly ATP-dependent microtubule motor activity, minus-end-directed ATPase activity dynein complex flagellated sperm motility motile cilium sperm flagellum inner dynein arm inner dynein arm assembly cell projection dynein intermediate chain binding dynein light intermediate chain binding cilium movement involved in cell motility uc007sxk.1 uc007sxk.2 uc007sxk.3 
ENSMUST00000048604.8 Msantd2 ENSMUST00000048604.8 Myb/SANT-like DNA-binding domain containing 2 (from RefSeq NM_146222.3) ENSMUST00000048604.1 ENSMUST00000048604.2 ENSMUST00000048604.3 ENSMUST00000048604.4 ENSMUST00000048604.5 ENSMUST00000048604.6 ENSMUST00000048604.7 MSD2_MOUSE NM_146222 Q6NZR2 Q8R3V3 uc009ouy.1 uc009ouy.2 uc009ouy.3 uc009ouy.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NZR2-1; Sequence=Displayed; Name=2; IsoId=Q6NZR2-2; Sequence=VSP_022707; molecular_function cellular_component biological_process uc009ouy.1 uc009ouy.2 uc009ouy.3 uc009ouy.4 
ENSMUST00000048605.3 Il5 ENSMUST00000048605.3 interleukin 5 (from RefSeq NM_010558.1) ENSMUST00000048605.1 ENSMUST00000048605.2 IL5 Il5 NM_010558 Q05A89 Q5SV01 Q5SV01_MOUSE uc007iwv.1 uc007iwv.2 uc007iwv.3 Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively. Homodimer; disulfide-linked. Secreted Belongs to the IL-5 family. cytokine activity interleukin-5 receptor binding extracellular region extracellular space inflammatory response immune response growth factor activity positive regulation of cell proliferation cytokine-mediated signaling pathway positive regulation of B cell proliferation positive regulation of eosinophil differentiation positive regulation of JAK-STAT cascade positive regulation of podosome assembly uc007iwv.1 uc007iwv.2 uc007iwv.3 
ENSMUST00000048613.14 A830018L16Rik ENSMUST00000048613.14 RIKEN cDNA A830018L16 gene, transcript variant 2 (from RefSeq NM_177173.6) CH034_MOUSE ENSMUST00000048613.1 ENSMUST00000048613.10 ENSMUST00000048613.11 ENSMUST00000048613.12 ENSMUST00000048613.13 ENSMUST00000048613.2 ENSMUST00000048613.3 ENSMUST00000048613.4 ENSMUST00000048613.5 ENSMUST00000048613.6 ENSMUST00000048613.7 ENSMUST00000048613.8 ENSMUST00000048613.9 NM_177173 Q3UVZ9 Q8BJN6 Q8BUZ5 Q8BZJ8 uc007ahx.1 uc007ahx.2 uc007ahx.3 uc007ahx.4 Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BZJ8-1; Sequence=Displayed; Name=2; IsoId=Q8BZJ8-2; Sequence=VSP_033018, VSP_033020; Name=3; IsoId=Q8BZJ8-3; Sequence=VSP_033016, VSP_033017; Name=4; IsoId=Q8BZJ8-4; Sequence=VSP_033019, VSP_033021; molecular_function cellular_component biological_process uc007ahx.1 uc007ahx.2 uc007ahx.3 uc007ahx.4 
ENSMUST00000048615.13 Pnp ENSMUST00000048615.13 purine-nucleoside phosphorylase (from RefSeq NM_013632.4) ENSMUST00000048615.1 ENSMUST00000048615.10 ENSMUST00000048615.11 ENSMUST00000048615.12 ENSMUST00000048615.2 ENSMUST00000048615.3 ENSMUST00000048615.4 ENSMUST00000048615.5 ENSMUST00000048615.6 ENSMUST00000048615.7 ENSMUST00000048615.8 ENSMUST00000048615.9 NM_013632 Pnp Q543K9 Q543K9_MOUSE uc007tme.1 uc007tme.2 uc007tme.3 uc007tme.4 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Reaction=2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + guanine; Xref=Rhea:RHEA:27738, ChEBI:CHEBI:16235, ChEBI:CHEBI:17172, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.1; Evidence= Reaction=2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + hypoxanthine; Xref=Rhea:RHEA:27750, ChEBI:CHEBI:17368, ChEBI:CHEBI:28997, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.1; Evidence= Reaction=guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine; Xref=Rhea:RHEA:13233, ChEBI:CHEBI:16235, ChEBI:CHEBI:16750, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.1; Evidence= Reaction=inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine; Xref=Rhea:RHEA:27646, ChEBI:CHEBI:17368, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.1; Evidence= Purine metabolism; purine nucleoside salvage. Homotrimer. Belongs to the PNP/MTAP phosphorylase family. catalytic activity purine-nucleoside phosphorylase activity nucleobase-containing compound metabolic process nucleoside metabolic process transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups uc007tme.1 uc007tme.2 uc007tme.3 uc007tme.4 
ENSMUST00000048621.8 Pmch ENSMUST00000048621.8 pro-melanin-concentrating hormone (from RefSeq NM_029971.2) ENSMUST00000048621.1 ENSMUST00000048621.2 ENSMUST00000048621.3 ENSMUST00000048621.4 ENSMUST00000048621.5 ENSMUST00000048621.6 ENSMUST00000048621.7 MCH_MOUSE Mch NM_029971 P56942 Q9D220 uc007grc.1 uc007grc.2 uc007grc.3 This gene encodes a preproprotein that is cleaved to produce three mature peptides: melanin concentrating hormone, neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). The proprotein is processed differently depending on the tissue where it is expressed. Melanin concentrating hormone is involved in the regulation of food intake, energy homeostasis, and sleep-wake behavior. Disruption of this gene is associated with resistance to diet-induced obesity. [provided by RefSeq, May 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC048534.1, AK138363.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. Secreted Predominantly expressed in hypothalamus. Also found in heart, intestine, spleen and testis (spermatogonia, early spermatocytes and Sertoli cells). In brain only mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly. Expression is enhanced between postnatal days 10 and 15. Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. Belongs to the MCH family. regulation of heart rate receptor binding hormone activity extracellular region extracellular space nucleus positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway chemical synaptic transmission feeding behavior response to cold melanin-concentrating hormone activity type 1 melanin-concentrating hormone receptor binding negative regulation of synaptic transmission, dopaminergic glucose homeostasis drinking behavior negative regulation of blood pressure positive regulation of circadian sleep/wake cycle, REM sleep regulation of neuronal synaptic plasticity uc007grc.1 uc007grc.2 uc007grc.3 
ENSMUST00000048630.8 Crtac1 ENSMUST00000048630.8 cartilage acidic protein 1, transcript variant 1 (from RefSeq NM_145123.5) Aspic1 CRAC1_MOUSE Cep68 ENSMUST00000048630.1 ENSMUST00000048630.2 ENSMUST00000048630.3 ENSMUST00000048630.4 ENSMUST00000048630.5 ENSMUST00000048630.6 ENSMUST00000048630.7 NM_145123 Q3UF32 Q3UF40 Q8BMF1 Q8R3V8 Q8R555 uc008hno.1 uc008hno.2 uc008hno.3 Secreted, extracellular space, extracellular matrix Sequence=AAH24472.1; Type=Erroneous initiation; Evidence=; calcium ion binding protein binding extracellular region axonal fasciculation olfactory bulb development growth cone negative regulation of receptor binding uc008hno.1 uc008hno.2 uc008hno.3 
ENSMUST00000048642.15 Parl ENSMUST00000048642.15 presenilin associated, rhomboid-like, transcript variant 12 (from RefSeq NR_184538.1) ENSMUST00000048642.1 ENSMUST00000048642.10 ENSMUST00000048642.11 ENSMUST00000048642.12 ENSMUST00000048642.13 ENSMUST00000048642.14 ENSMUST00000048642.2 ENSMUST00000048642.3 ENSMUST00000048642.4 ENSMUST00000048642.5 ENSMUST00000048642.6 ENSMUST00000048642.7 ENSMUST00000048642.8 ENSMUST00000048642.9 NR_184538 PARL_MOUSE Psarl Q3U9T5 Q5XJY4 Q641T5 uc007ypm.1 uc007ypm.2 uc007ypm.3 uc007ypm.4 Required for the control of apoptosis during postnatal growth (PubMed:16839884). Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (PubMed:16839884). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (By similarity). Promotes cleavage of serine/threonine-protein phosphatase PGAM5 in damaged mitochondria in response to loss of mitochondrial membrane potential (By similarity). Mediates differential cleavage of PINK1 and PGAM5 depending on the health status of mitochondria, disassociating from PINK1 and associating with PGAM5 in response to mitochondrial membrane potential loss (By similarity). Required for processing of CLPB into a form with higher protein disaggregase activity by removing an autoinhibitory N-terminal peptide (By similarity). Promotes processing of DIABLO/SMAC in the mitochondrion which is required for DIABLO apoptotic activity (By similarity). Also required for cleavage of STARD7 and TTC19 (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; Evidence=; Interacts with PSEN1 and PSEN2 (By similarity). Binds OPA1. Q5XJY4; O35387: Hax1; NbExp=2; IntAct=EBI-5395457, EBI-642449; Mitochondrion inner membrane ; Multi-pass membrane protein [P-beta]: Nucleus Note=Translocated into the nucleus by an unknown mechanism (By similarity). P-beta is proteolytically processed (beta-cleavage) in a PARL- dependent manner. Mice develop normally until 4 weeks of age. They show subsequent progressive growth retardation, atrophy of muscle, spleen, and thymus as well as severe apoptosis of T and B lymphocytes leading to premature death between 8-12 weeks of age. Mouse embryonic fibroblasts lacking Parl show high susceptibility to intrinsic apoptotic signals. This defect can be complemented by Parl or a soluble form of Opa1. Belongs to the peptidase S54 family. endopeptidase activity serine-type endopeptidase activity protein binding nucleus mitochondrion mitochondrial inner membrane proteolysis peptidase activity serine-type peptidase activity regulation of mitochondrion organization membrane integral component of membrane hydrolase activity regulation of proteolysis negative regulation of release of cytochrome c from mitochondria regulation of mitophagy regulation of protein targeting to mitochondrion regulation of reactive oxygen species metabolic process negative regulation of intrinsic apoptotic signaling pathway uc007ypm.1 uc007ypm.2 uc007ypm.3 uc007ypm.4 
ENSMUST00000048644.6 Pnliprp1 ENSMUST00000048644.6 pancreatic lipase related protein 1 (from RefSeq NM_018874.2) ENSMUST00000048644.1 ENSMUST00000048644.2 ENSMUST00000048644.3 ENSMUST00000048644.4 ENSMUST00000048644.5 LIPR1_MOUSE NM_018874 O70478 Q5BKQ4 Q6NV82 uc008iat.1 uc008iat.2 May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity). Secreted Note=Secreted in acinar cells. Expressed in female, but not in male, lacrimal gland. Expressed in male and female sublingual gland and pancreas. Mice have no visible phenotype during the first 10 weeks after birth and are fertile. Adult mice have normal body weight, but higher than normal body fat and lower than normal lean mass. They display impaired glucose tolerance and decreased insulin sensitivity, and obesity and insulin resistance are exacerbated by high-fat diet. Their pancreatic juice has greater ability to hydrolyze triglycerides than that from wild-type littermates. Expression is gender and species-specific. Belongs to the AB hydrolase superfamily. Lipase family. triglyceride lipase activity calcium ion binding extracellular region extracellular space lipid metabolic process lipase activity metal ion binding carboxylic ester hydrolase activity uc008iat.1 uc008iat.2 
ENSMUST00000048646.9 Vps13b ENSMUST00000048646.9 vacuolar protein sorting 13B (from RefSeq NM_177151.4) Coh1 E9QKX5 ENSMUST00000048646.1 ENSMUST00000048646.2 ENSMUST00000048646.3 ENSMUST00000048646.4 ENSMUST00000048646.5 ENSMUST00000048646.6 ENSMUST00000048646.7 ENSMUST00000048646.8 Kiaa0532 NM_177151 Q80TY5 VP13B_MOUSE Vps13b uc007vmh.1 uc007vmh.2 uc007vmh.3 uc007vmh.4 Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3- phosphate (PubMed:30962439). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (By similarity). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (PubMed:31218450). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (By similarity). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:31495077). May also play a role during adipose tissue development (By similarity). Required for maintenance of the ocular lens (PubMed:32915983). Required for proper organization of the Golgi (By similarity). Interacts with STX6 (PubMed:30962439). Interacts with STX12 (via N-terminus) (PubMed:30962439). Interacts with RAB6A isoform 1 (GTP-bound) and isoform 2 (GTP-bound) (By similarity). Interacts with RAB6B (GTP-bound) (By similarity). Recycling endosome membrane ; Peripheral membrane protein Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Peripheral membrane protein Golgi apparatus, cis-Golgi network membrane ; Peripheral membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Peripheral membrane protein Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Early endosome membrane ; Peripheral membrane protein Lysosome membrane ; Peripheral membrane protein Note=Localizes to proacrosomal and acrosomal vesicles and not the Golgi apparatus during acrosome formation. Ubiquitously expressed in all examined tissues. Belongs to the VPS13 family. molecular_function cellular_component biological_process protein transport uc007vmh.1 uc007vmh.2 uc007vmh.3 uc007vmh.4 
ENSMUST00000048647.14 Rbm46 ENSMUST00000048647.14 RNA binding motif protein 46, transcript variant 1 (from RefSeq NM_001146328.3) ENSMUST00000048647.1 ENSMUST00000048647.10 ENSMUST00000048647.11 ENSMUST00000048647.12 ENSMUST00000048647.13 ENSMUST00000048647.2 ENSMUST00000048647.3 ENSMUST00000048647.4 ENSMUST00000048647.5 ENSMUST00000048647.6 ENSMUST00000048647.7 ENSMUST00000048647.8 ENSMUST00000048647.9 NM_001146328 P86049 RBM46_MOUSE Rbm46 uc057lfu.1 uc057lfu.2 uc057lfu.3 Essential for male and female fertility, playing a crucial role in regulating germ cell development by ensuring the proper progression of meiosis prophase I (PubMed:36129965, PubMed:36001654, PubMed:36726756). Regulates mitotic-to-meiotic transition in spermatogenesis by forming a complex with MEIOC and YTHDC2 which recognizes and down-regulates mitotic transcripts for a successful meiotic entry (PubMed:36129965). Required for normal synaptonemal complex formation during meiosis, binding meiotic cohesin subunit mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions and positively regulating their translation (PubMed:36726756). Required for spermatogonial differentiation in both developing and adult testis (PubMed:36129965). Interacts with YTHDC2, MEIOC, MOV10, CNOT6L, DDX4, UPF1 and PABPC1. Cytoplasm Expressed in the testis and ovary (at protein level) (PubMed:36129965, PubMed:36001654, PubMed:36726756). Expressed in spermatogonia and spermatocytes in testis (at protein level) (PubMed:36129965, PubMed:36001654). Male and female mice are infertile and show meiotic arrest in spermatocytes and oocytes (PubMed:36129965, PubMed:36001654, PubMed:36726756). Severely impaired spermatogenesis with a complete absence of postmeiotic germ cells and a marked decrease of spermatocytes in meiotic prophase I seen in adult testis (PubMed:36001654). Spermatogonial differentiation is impaired in developing testis (PubMed:36129965). RBM46-target cohesin subunits display unaltered mRNA levels but have reduced translation, resulting in the failed assembly of axial elements, synapsis disruption, and meiotic arrest (PubMed:36726756). trophectodermal cell differentiation nucleic acid binding RNA binding mRNA binding nucleus mRNA stabilization uc057lfu.1 uc057lfu.2 uc057lfu.3 
ENSMUST00000048653.10 Cpne2 ENSMUST00000048653.10 copine II (from RefSeq NM_153507.2) CPNE2_MOUSE Cpne2 ENSMUST00000048653.1 ENSMUST00000048653.2 ENSMUST00000048653.3 ENSMUST00000048653.4 ENSMUST00000048653.5 ENSMUST00000048653.6 ENSMUST00000048653.7 ENSMUST00000048653.8 ENSMUST00000048653.9 NM_153507 P59108 Q8K1D7 uc009mwm.1 uc009mwm.2 uc009mwm.3 Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: BC031801.1, AK160238.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium- dependent cell membrane binding properties (PubMed:21087455, PubMed:26175110). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per C2 domain. Cytoplasm cleus ll membrane Note=Translocates to the cell membrane and the nucleus in a calcium- dependent manner (PubMed:21087455, PubMed:26175110). Colocalizes with CD2 at the cell membrane (PubMed:21087455). The C2 domain 2, but not the C2 domain 1, is necessary for calcium-mediated membrane association (PubMed:21087455, PubMed:26175110). The linker region is necessary for calcium-dependent cell membrane association (PubMed:21087455). Belongs to the copine family. calcium-dependent phospholipid binding nucleus cytoplasm plasma membrane membrane cellular response to calcium ion clathrin-coated endocytic vesicle uc009mwm.1 uc009mwm.2 uc009mwm.3 
ENSMUST00000048655.8 Dusp10 ENSMUST00000048655.8 dual specificity phosphatase 10 (from RefSeq NM_022019.6) DUS10_MOUSE ENSMUST00000048655.1 ENSMUST00000048655.2 ENSMUST00000048655.3 ENSMUST00000048655.4 ENSMUST00000048655.5 ENSMUST00000048655.6 ENSMUST00000048655.7 Mkp5 NM_022019 Q8R3L3 Q9CZY9 Q9ESS0 uc007dym.1 uc007dym.2 uc007dym.3 Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Monomer. Interacts with MAPK14. Cytoplasm Nucleus Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. inactivation of MAPK activity regulation of adaptive immune response phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus nucleoplasm cytoplasm Golgi apparatus cytosol protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity JUN kinase binding response to organic substance negative regulation of epithelial cell migration dephosphorylation nuclear speck hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity response to lipopolysaccharide negative regulation of stress-activated MAPK cascade MAP kinase phosphatase activity peptidyl-threonine dephosphorylation negative regulation of JUN kinase activity negative regulation of protein kinase activity by regulation of protein phosphorylation regulation of innate immune response positive regulation of regulatory T cell differentiation negative regulation of JNK cascade mitogen-activated protein kinase p38 binding oligodendrocyte differentiation negative regulation of oligodendrocyte differentiation negative regulation of epithelial cell proliferation negative regulation of respiratory burst involved in inflammatory response negative regulation of ERK1 and ERK2 cascade regulation of brown fat cell differentiation negative regulation of p38MAPK cascade negative regulation of epithelium regeneration peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity uc007dym.1 uc007dym.2 uc007dym.3 
ENSMUST00000048657.10 Sec24c ENSMUST00000048657.10 SEC24 homolog C, COPII coat complex component, transcript variant 1 (from RefSeq NM_172596.2) ENSMUST00000048657.1 ENSMUST00000048657.2 ENSMUST00000048657.3 ENSMUST00000048657.4 ENSMUST00000048657.5 ENSMUST00000048657.6 ENSMUST00000048657.7 ENSMUST00000048657.8 ENSMUST00000048657.9 G3X972 G3X972_MOUSE NM_172596 Sec24c uc007skg.1 uc007skg.2 uc007skg.3 uc007skg.4 Cytoplasm, cytosol Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the SEC23/SEC24 family. SEC24 subfamily. Golgi membrane SNARE binding in utero embryonic development cytosol intracellular protein transport ER to Golgi vesicle-mediated transport zinc ion binding protein transport COPII vesicle coat cargo loading into COPII-coated vesicle uc007skg.1 uc007skg.2 uc007skg.3 uc007skg.4 
ENSMUST00000048665.8 Chd9 ENSMUST00000048665.8 chromodomain helicase DNA binding protein 9, transcript variant 2 (from RefSeq NM_177224.2) CHD9_MOUSE ENSMUST00000048665.1 ENSMUST00000048665.2 ENSMUST00000048665.3 ENSMUST00000048665.4 ENSMUST00000048665.5 ENSMUST00000048665.6 ENSMUST00000048665.7 Kiaa0308 NM_177224 Pric320 Q7TMV5 Q8BJG8 Q8BYH8 Q8BZJ2 Q8CHG8 uc009msf.1 uc009msf.2 uc009msf.3 uc009msf.4 Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T- rich DNA (By similarity). Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Interacts with PPARA. Probably interacts with ESR1 and NR1I3 (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BYH8-1; Sequence=Displayed; Name=2; IsoId=Q8BYH8-2; Sequence=VSP_018087; Expressed in osteoprogenitor cells during development and in mature bone (at protein level). Expressed from embryonic day 16.5 dpc in mesenchymal cartilage surrounding bone cartilage and newly formed bone trabecular spicules. Detected in bone sections of 4-day-old newborn and 3-week-old mice. Phosphorylated on serine and tyrosine residues. Belongs to the SNF2/RAD54 helicase family. Sequence=AAH52896.1; Type=Erroneous initiation; Evidence=; nucleotide binding DNA binding DNA helicase activity helicase activity ATP binding nucleus cytoplasm chromatin organization biological_process hydrolase activity hydrolase activity, acting on acid anhydrides DNA duplex unwinding uc009msf.1 uc009msf.2 uc009msf.3 uc009msf.4 
ENSMUST00000048670.10 Slc35f2 ENSMUST00000048670.10 solute carrier family 35, member F2 (from RefSeq NM_028060.3) ENSMUST00000048670.1 ENSMUST00000048670.2 ENSMUST00000048670.3 ENSMUST00000048670.4 ENSMUST00000048670.5 ENSMUST00000048670.6 ENSMUST00000048670.7 ENSMUST00000048670.8 ENSMUST00000048670.9 NM_028060 Q7TML3 Q9DB62 S35F2_MOUSE uc009pmn.1 uc009pmn.2 uc009pmn.3 uc009pmn.4 Putative solute transporter. Membrane ; Multi-pass membrane protein Belongs to the SLC35F solute transporter family. molecular_function cellular_component biological_process membrane integral component of membrane transmembrane transporter activity transmembrane transport uc009pmn.1 uc009pmn.2 uc009pmn.3 uc009pmn.4 
ENSMUST00000048675.2 Magea4 ENSMUST00000048675.2 MAGE family member A4 (from RefSeq NM_020280.2) ENSMUST00000048675.1 F2Z493 F2Z493_MOUSE Magea4 NM_020280 uc009tkl.1 uc009tkl.2 molecular_function nucleoplasm cytosol biological_process nuclear body uc009tkl.1 uc009tkl.2 
ENSMUST00000048677.9 Tbc1d22b ENSMUST00000048677.9 TBC1 domain family, member 22B, transcript variant 5 (from RefSeq NR_182277.1) BC045600 ENSMUST00000048677.1 ENSMUST00000048677.2 ENSMUST00000048677.3 ENSMUST00000048677.4 ENSMUST00000048677.5 ENSMUST00000048677.6 ENSMUST00000048677.7 ENSMUST00000048677.8 NR_182277 Q80VE5 Q80VE5_MOUSE Tbc1d22b uc008btd.1 uc008btd.2 uc008btd.3 GTPase activator activity cell intracellular protein transport Rab GTPase binding 14-3-3 protein binding activation of GTPase activity uc008btd.1 uc008btd.2 uc008btd.3 
ENSMUST00000048678.7 Lss ENSMUST00000048678.7 lanosterol synthase (from RefSeq NM_146006.2) ENSMUST00000048678.1 ENSMUST00000048678.2 ENSMUST00000048678.3 ENSMUST00000048678.4 ENSMUST00000048678.5 ENSMUST00000048678.6 LSS_MOUSE Lss NM_146006 Q8BLN5 Q8BVJ4 Q8K307 uc007fuq.1 uc007fuq.2 uc007fuq.3 uc007fuq.4 This gene encodes an enzyme that catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. [provided by RefSeq, Feb 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK031271.1, AK154520.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. Reaction=(S)-2,3-epoxysqualene = lanosterol; Xref=Rhea:RHEA:14621, ChEBI:CHEBI:15441, ChEBI:CHEBI:16521; EC=5.4.99.7; Evidence=; Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3. Monomer. Endoplasmic reticulum membrane ; Peripheral membrane protein Belongs to the terpene cyclase/mutase family. lanosterol synthase activity endoplasmic reticulum endoplasmic reticulum membrane lipid particle lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process membrane triterpenoid biosynthetic process sterol metabolic process isomerase activity intramolecular transferase activity regulation of protein stability beta-amyrin synthase activity intracellular membrane-bounded organelle uc007fuq.1 uc007fuq.2 uc007fuq.3 uc007fuq.4 
ENSMUST00000048680.8 Hoxa9 ENSMUST00000048680.8 homeobox A9, transcript variant 1 (from RefSeq NM_010456.4) ENSMUST00000048680.1 ENSMUST00000048680.2 ENSMUST00000048680.3 ENSMUST00000048680.4 ENSMUST00000048680.5 ENSMUST00000048680.6 ENSMUST00000048680.7 HXA9_MOUSE Hox-1.7 Hoxa-9 NM_010456 O70154 O70155 P09631 uc009byl.1 uc009byl.2 uc009byl.3 uc009byl.4 This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of similar genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important for hematopoeisis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cell surface at sites of inflammation (By similarity). Positively regulates EIF4E- mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (PubMed:15657436). Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells (By similarity). Interacts with EIF4E (PubMed:15657436). P09631; Q9Z148: Ehmt2; NbExp=2; IntAct=EBI-925334, EBI-444966; P09631; P41778: Pbx1; NbExp=2; IntAct=EBI-925334, EBI-6996259; Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=HoxA-9; IsoId=P09631-1; Sequence=Displayed; Name=HoxA-9T; IsoId=P09631-2; Sequence=VSP_002382, VSP_002383; Expressed in high level in the embryonic and adult spinal cord with a preference in the posterior region. Methylated on Arg-140 by PRMT5; methylation is critical for E- selectin induction. Belongs to the Abd-B homeobox family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein binding nucleus transcription factor complex cytoplasm transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development spermatogenesis single fertilization male gonad development anterior/posterior pattern specification proximal/distal pattern formation regulation of gene expression enzyme binding mammary gland development embryonic forelimb morphogenesis endothelial cell activation sequence-specific DNA binding negative regulation of myeloid cell differentiation positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system development uterus development definitive hemopoiesis uc009byl.1 uc009byl.2 uc009byl.3 uc009byl.4 
ENSMUST00000048686.9 Prb1b ENSMUST00000048686.9 proline-rich protein BstNI subfamily 1B (from RefSeq NM_001024705.2) E9PXN1 E9PXN1_MOUSE ENSMUST00000048686.1 ENSMUST00000048686.2 ENSMUST00000048686.3 ENSMUST00000048686.4 ENSMUST00000048686.5 ENSMUST00000048686.6 ENSMUST00000048686.7 ENSMUST00000048686.8 NM_001024705 Prb1b Prpmp5 uc009ejd.1 uc009ejd.2 uc009ejd.3 molecular_function cellular_component biological_process uc009ejd.1 uc009ejd.2 uc009ejd.3 
ENSMUST00000048687.11 Tceal9 ENSMUST00000048687.11 transcription elongation factor A like 9 (from RefSeq NM_011712.2) A3KG99 ENSMUST00000048687.1 ENSMUST00000048687.10 ENSMUST00000048687.2 ENSMUST00000048687.3 ENSMUST00000048687.4 ENSMUST00000048687.5 ENSMUST00000048687.6 ENSMUST00000048687.7 ENSMUST00000048687.8 ENSMUST00000048687.9 NM_011712 O08549 Q9DD24 TCAL9_MOUSE Wbp5 uc009uij.1 uc009uij.2 uc009uij.3 May be involved in transcriptional regulation. Nucleus Belongs to the TFS-II family. TFA subfamily. Sequence=AAC53191.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; nucleus WW domain binding uc009uij.1 uc009uij.2 uc009uij.3 
ENSMUST00000048688.8 Fbxo38 ENSMUST00000048688.8 F-box protein 38, transcript variant 5 (from RefSeq NM_134136.4) ENSMUST00000048688.1 ENSMUST00000048688.2 ENSMUST00000048688.3 ENSMUST00000048688.4 ENSMUST00000048688.5 ENSMUST00000048688.6 ENSMUST00000048688.7 FBX38_MOUSE Fbxo38 NM_134136 Q8BMI0 Q8BTQ4 Q8C0H4 uc012bdv.1 uc012bdv.2 uc012bdv.3 uc012bdv.4 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (PubMed:14729953, PubMed:16990251). Protein modification; protein ubiquitination. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO38) composed of CUL1, SKP1, RBX1 and FBXO38 (By similarity). Interacts with KLF7 (PubMed:14729953). Interacts with PDCD1/PD-1 (By similarity). Cytoplasm, cytosol cleus te=Accumulates predominantly in the cytosol (PubMed:16990251). Exported from the nucleus in a XPO1/CRM1- dependent manner (PubMed:16990251). Expressed at high levels in embryo (developing brain, spinal chord, branchial arms and limbs) (PubMed:14729953). Widely expressed at low levels in adult tissues, with highest expression in testis. Expressed in postmeiotic spermatids (PubMed:14729953). In embryo expressed at 11 dpc, 15 dpc and 17 dpc. Up-regulated by IL2 (PubMed:30487606). Down-regulated in tumor-infiltrating T-cells (PubMed:30487606). Conditional deletion in T-cells does not affect the development, peripheral homeostasis and population of memory T- cells, but leads to faster tumor progression (PubMed:30487606). Faster tumor progression is caused by higher levels of Pdcd1/PD-1 in tumor- infiltrating T-cells (PubMed:30487606). adaptive immune response immune system process positive regulation of T cell mediated immune response to tumor cell protein binding nucleus cytoplasm cytosol positive regulation of neuron projection development protein ubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein K48-linked ubiquitination uc012bdv.1 uc012bdv.2 uc012bdv.3 uc012bdv.4 
ENSMUST00000048691.6 Ptchd4 ENSMUST00000048691.6 patched domain containing 4, transcript variant 2 (from RefSeq NM_028474.1) 3110082D06Rik E9QMK6 E9QMK6_MOUSE ENSMUST00000048691.1 ENSMUST00000048691.2 ENSMUST00000048691.3 ENSMUST00000048691.4 ENSMUST00000048691.5 NM_028474 Ptchd4 uc012ato.1 uc012ato.2 uc012ato.3 Belongs to the patched family. membrane integral component of membrane uc012ato.1 uc012ato.2 uc012ato.3 
ENSMUST00000048702.7 Tent2 ENSMUST00000048702.7 terminal nucleotidyltransferase 2, transcript variant 1 (from RefSeq NM_133905.3) A4F5H0 ENSMUST00000048702.1 ENSMUST00000048702.2 ENSMUST00000048702.3 ENSMUST00000048702.4 ENSMUST00000048702.5 ENSMUST00000048702.6 GLD2_MOUSE Gld2 NM_133905 Papd4 Q8CCH5 Q91YI6 uc007rla.1 uc007rla.2 uc007rla.3 Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs. Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, ChEBI:CHEBI:173115; EC=2.7.7.19; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Interacts with CPEB1, CPEB2, CPSF1 and PABPC1 (PubMed:17927953). Interacts with QKI isoform QKI7; promoting recruitment to miRNA miR-122 and miR-122 stabilization (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91YI6-1; Sequence=Displayed; Name=2; IsoId=Q91YI6-2; Sequence=VSP_034325; Ubiquitous. In brain, it is highly expressed in the cerebral cortex, cerebellum, hippocampus and olfactory bulb. Expressed in oocytes from metaphase I to metaphase II during oocyte maturation. Mice are normal and healthy. Poly-A tail elongation in oocytes is not affected and mice are fertile. Belongs to the DNA polymerase type-B-like family. GLD2 subfamily. Sequence=BAC28170.1; Type=Frameshift; Evidence=; nucleotide binding hematopoietic progenitor cell differentiation polynucleotide adenylyltransferase activity protein binding ATP binding nucleus cytoplasm cytosol mRNA processing transferase activity hippocampus development neuron differentiation 5'-3' RNA polymerase activity RNA stabilization RNA polyadenylation metal ion binding retina development in camera-type eye adenylyltransferase activity histone mRNA catabolic process dark adaptation negative regulation of miRNA catabolic process uc007rla.1 uc007rla.2 uc007rla.3 
ENSMUST00000048706.10 Orc3 ENSMUST00000048706.10 origin recognition complex, subunit 3, transcript variant 1 (from RefSeq NM_015824.4) A2AMF4 A2AMF5 ENSMUST00000048706.1 ENSMUST00000048706.2 ENSMUST00000048706.3 ENSMUST00000048706.4 ENSMUST00000048706.5 ENSMUST00000048706.6 ENSMUST00000048706.7 ENSMUST00000048706.8 ENSMUST00000048706.9 NM_015824 ORC3_MOUSE Orc3l Q6P8H2 Q8BR83 Q8C395 Q9JK30 uc008sgb.1 uc008sgb.2 uc008sgb.3 uc008sgb.4 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Nucleus Chromosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JK30-1; Sequence=Displayed; Name=2; IsoId=Q9JK30-2; Sequence=VSP_026407; Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle. Belongs to the ORC3 family. It is uncertain whether Met-1 or Met-8 is the initiator. chromatin origin recognition complex DNA binding DNA replication origin binding nucleus nucleoplasm nuclear pre-replicative complex nuclear origin of replication recognition complex DNA replication pre-replicative complex assembly involved in nuclear cell cycle DNA replication DNA replication initiation regulation of DNA replication nuclear body DNA replication preinitiation complex neural precursor cell proliferation uc008sgb.1 uc008sgb.2 uc008sgb.3 uc008sgb.4 
ENSMUST00000048715.9 Hoxa7 ENSMUST00000048715.9 homeobox A7, transcript variant 1 (from RefSeq NM_010455.3) A2RS54 ENSMUST00000048715.1 ENSMUST00000048715.2 ENSMUST00000048715.3 ENSMUST00000048715.4 ENSMUST00000048715.5 ENSMUST00000048715.6 ENSMUST00000048715.7 ENSMUST00000048715.8 HXA7_MOUSE Hox-1.1 Hoxa-7 NM_010455 P02830 Q544P0 uc009byj.1 uc009byj.2 uc009byj.3 uc009byj.4 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus. Belongs to the Antp homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis negative regulation of cell-matrix adhesion negative regulation of leukocyte migration DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development transcription factor binding anterior/posterior pattern specification nuclear membrane sequence-specific DNA binding negative regulation of keratinocyte differentiation negative regulation of monocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system morphogenesis stem cell differentiation uc009byj.1 uc009byj.2 uc009byj.3 uc009byj.4 
ENSMUST00000048718.4 Mmaa ENSMUST00000048718.4 methylmalonic aciduria (cobalamin deficiency) type A, transcript variant 2 (from RefSeq NM_133823.5) ENSMUST00000048718.1 ENSMUST00000048718.2 ENSMUST00000048718.3 MMAA_MOUSE Mmaa NM_133823 Q8C7H1 Q8R2N3 Q8VC22 uc009min.1 uc009min.2 uc009min.3 uc009min.4 GTPase, binds and hydrolyzes GTP (By similarity). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (By similarity). Functions as a G- protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (By similarity). Plays a dual role as both a protectase and a reactivase for MMUT (By similarity). Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) (By similarity). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; GTPase activity is stimulated by MMUT. Homodimer. Interacts with MMUT (the apoenzyme form); the interaction is GTP dependent. Mitochondrion Cytoplasm Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. nucleotide binding GTPase activity GTP binding cellular_component mitochondrion biological_process cobalamin biosynthetic process hydrolase activity identical protein binding protein homodimerization activity uc009min.1 uc009min.2 uc009min.3 uc009min.4 
ENSMUST00000048731.6 Arpin ENSMUST00000048731.6 actin-related protein 2/3 complex inhibitor (from RefSeq NM_027420.4) ARPIN_MOUSE ENSMUST00000048731.1 ENSMUST00000048731.2 ENSMUST00000048731.3 ENSMUST00000048731.4 ENSMUST00000048731.5 NM_027420 Q3U1F3 Q8CA84 Q9D0A3 uc009hzh.1 uc009hzh.2 uc009hzh.3 Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence (By similarity). Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1. Cell projection, lamellipodium Note=Colocalized with the WAVE complex at lamellipodium tip. The acidic C-terminus is necessary and sufficient to inhibit ARP2/3 complex activity. Belongs to the Arpin family. molecular_function lamellipodium negative regulation of cell migration directional locomotion cell projection negative regulation of actin nucleation negative regulation of lamellipodium morphogenesis uc009hzh.1 uc009hzh.2 uc009hzh.3 
ENSMUST00000048762.8 Cilp ENSMUST00000048762.8 cartilage intermediate layer protein, nucleotide pyrophosphohydrolase, transcript variant 1 (from RefSeq NM_173385.3) A0A0R4J0F8 A0A0R4J0F8_MOUSE Cilp ENSMUST00000048762.1 ENSMUST00000048762.2 ENSMUST00000048762.3 ENSMUST00000048762.4 ENSMUST00000048762.5 ENSMUST00000048762.6 ENSMUST00000048762.7 NM_173385 uc009qcz.1 uc009qcz.2 Secreted, extracellular space, extracellular matrix extracellular space negative regulation of gene expression negative regulation of insulin-like growth factor receptor signaling pathway negative regulation of SMAD protein import into nucleus cellular response to transforming growth factor beta stimulus uc009qcz.1 uc009qcz.2 
ENSMUST00000048770.16 Sh3bgr ENSMUST00000048770.16 SH3-binding domain glutamic acid-rich protein (from RefSeq NM_015825.2) ENSMUST00000048770.1 ENSMUST00000048770.10 ENSMUST00000048770.11 ENSMUST00000048770.12 ENSMUST00000048770.13 ENSMUST00000048770.14 ENSMUST00000048770.15 ENSMUST00000048770.2 ENSMUST00000048770.3 ENSMUST00000048770.4 ENSMUST00000048770.5 ENSMUST00000048770.6 ENSMUST00000048770.7 ENSMUST00000048770.8 ENSMUST00000048770.9 NM_015825 Q9WUZ7 SH3BG_MOUSE uc008acu.1 uc008acu.2 uc008acu.3 Belongs to the SH3BGR family. molecular_function biological_process SH3 domain binding uc008acu.1 uc008acu.2 uc008acu.3 
ENSMUST00000048774.13 Copg2 ENSMUST00000048774.13 coatomer protein complex, subunit gamma 2, transcript variant 4 (from RefSeq NR_183248.1) A6H6J5 COPG2_MOUSE ENSMUST00000048774.1 ENSMUST00000048774.10 ENSMUST00000048774.11 ENSMUST00000048774.12 ENSMUST00000048774.2 ENSMUST00000048774.3 ENSMUST00000048774.4 ENSMUST00000048774.5 ENSMUST00000048774.6 ENSMUST00000048774.7 ENSMUST00000048774.8 ENSMUST00000048774.9 NR_183248 Q3TQD5 Q3UEL6 Q8C2J6 Q9QXK3 uc029vty.1 uc029vty.2 uc029vty.3 uc029vty.4 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Oligomeric complex. Binds to CDC42. Interacts with JAGN1. Interacts with TMED10 (via cytoplasmic domain). Cytoplasm, cytosol Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Tends to be more abundant in the trans-Golgi network compared to the cis-Golgi. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9QXK3-1; Sequence=Displayed; Name=2; IsoId=Q9QXK3-2; Sequence=VSP_034480, VSP_034481; Name=3; IsoId=Q9QXK3-3; Sequence=VSP_034482, VSP_034483; Name=4; IsoId=Q9QXK3-4; Sequence=VSP_034484; Belongs to the COPG family. Golgi membrane structural molecule activity cytoplasm endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cytosol intracellular protein transport ER to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport protein secretion protein transport membrane vesicle-mediated transport membrane coat COPI vesicle coat COPI-coated vesicle membrane cytoplasmic vesicle organelle transport along microtubule uc029vty.1 uc029vty.2 uc029vty.3 uc029vty.4 
ENSMUST00000048777.4 Ccr8 ENSMUST00000048777.4 C-C motif chemokine receptor 8 (from RefSeq NM_007720.2) Ccr8 ENSMUST00000048777.1 ENSMUST00000048777.2 ENSMUST00000048777.3 NM_007720 Q3ZB17 Q3ZB17_MOUSE uc009sca.1 uc009sca.2 uc009sca.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity chemokine receptor activity cell chemotaxis immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane C-C chemokine receptor activity chemokine-mediated signaling pathway uc009sca.1 uc009sca.2 uc009sca.3 
ENSMUST00000048782.7 Trem1 ENSMUST00000048782.7 triggering receptor expressed on myeloid cells 1, transcript variant 1 (from RefSeq NM_021406.5) ENSMUST00000048782.1 ENSMUST00000048782.2 ENSMUST00000048782.3 ENSMUST00000048782.4 ENSMUST00000048782.5 ENSMUST00000048782.6 NM_021406 Q3TAL7 Q9JKE2 TREM1_MOUSE uc029tij.1 uc029tij.2 uc029tij.3 uc029tij.4 Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:23241959, PubMed:27328755). By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (By similarity). Monomer (PubMed:15561137). Homomultimer; when activated. Interacts with TYROBP/DAP12. Interacts with TLR4 (By similarity). Cell membrane ; Single-pass type I membrane protein Note=Recruited to lipid rafts when activated. Deletion mutants do not show any influence of the antiviral T-cell response. However, TREM1 deficiency impairs secretion of CCL2 and TNF-alpha by neutrophils in response to viruses (PubMed:27328755). TREM-1/3-deficient animals have decreased neutrophils in the airway and these neutrophils have a defect in transepithelial migration (PubMed:23241959). cytokine secretion involved in immune response acute inflammatory response membrane integral component of membrane cell migration neutrophil chemotaxis signaling receptor activity cytokine metabolic process chemokine metabolic process neutrophil mediated killing of gram-negative bacterium neutrophil extravasation scaffold protein binding uc029tij.1 uc029tij.2 uc029tij.3 uc029tij.4 
ENSMUST00000048786.13 Cibar2 ENSMUST00000048786.13 CBY1 interacting BAR domain containing 2 (from RefSeq NM_001033980.2) B2RVK4 CBAR2_MOUSE Cibar2 ENSMUST00000048786.1 ENSMUST00000048786.10 ENSMUST00000048786.11 ENSMUST00000048786.12 ENSMUST00000048786.2 ENSMUST00000048786.3 ENSMUST00000048786.4 ENSMUST00000048786.5 ENSMUST00000048786.6 ENSMUST00000048786.7 ENSMUST00000048786.8 ENSMUST00000048786.9 Fam92b NM_001033980 Q3V2J0 uc033jid.1 uc033jid.2 uc033jid.3 May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis. Homodimer (via BAR-like domain). Heterodimer (via BAR-like domain) with FAM92A. Interacts with CBY1. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body Note=Extensive colocalization with CBY1 at mother centrioles (PubMed:27528616). The BAR-like domain displays limited similarity to other BAR domains. Belongs to the CIBAR family. molecular_function cytoplasm centriole cytoskeleton biological_process cell projection organization ciliary basal body cell projection uc033jid.1 uc033jid.2 uc033jid.3 
ENSMUST00000048788.14 Nepro ENSMUST00000048788.14 nucleolus and neural progenitor protein, transcript variant 1 (from RefSeq NM_145972.5) ENSMUST00000048788.1 ENSMUST00000048788.10 ENSMUST00000048788.11 ENSMUST00000048788.12 ENSMUST00000048788.13 ENSMUST00000048788.2 ENSMUST00000048788.3 ENSMUST00000048788.4 ENSMUST00000048788.5 ENSMUST00000048788.6 ENSMUST00000048788.7 ENSMUST00000048788.8 ENSMUST00000048788.9 NEPRO_MOUSE NM_145972 Nepro Q8R2U2 uc007zho.1 uc007zho.2 uc007zho.3 May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors (PubMed:19906856). May also play a role in preimplentation embryo development (PubMed:26178919). Nucleus Nucleus, nucleolus Expressed in all blastomeres at the 8-cell stage (PubMed:26178919). Detected in the ventricular zone (VZ) of the forebrain at 9.5 dpc. Clearly detected until 12.5 dpc, the expression decreases and disappears by 15.5 dpc (PubMed:19906856). Knockout embryos die before preimplantation. Belongs to the nepro family. molecular_function nucleus nucleolus multicellular organism development negative regulation of neuron differentiation positive regulation of Notch signaling pathway uc007zho.1 uc007zho.2 uc007zho.3 
ENSMUST00000048790.7 Prrg3 ENSMUST00000048790.7 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane), transcript variant 1 (from RefSeq NM_001081135.3) A3KGD9 B2RPV1 ENSMUST00000048790.1 ENSMUST00000048790.2 ENSMUST00000048790.3 ENSMUST00000048790.4 ENSMUST00000048790.5 ENSMUST00000048790.6 Gm368 NM_001081135 Q6PAQ9 TMG3_MOUSE Tmg3 uc009tkh.1 uc009tkh.2 uc009tkh.3 This gene encodes proline-rich gamma-carboxyglutamic acid protein 3, a member of vitamin K-dependent membrane proteins containing gamma-carboxyglutamic acid residues. The encoded precursor protein contains an N-terminal propeptide that is required for the carboxylation of glutamate residues in the mature protein. Alternate splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, Dec 2014]. Membrane ; Single-pass type I membrane protein Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase. Sequence=BC060135; Type=Frameshift; Evidence=; molecular_function calcium ion binding cellular_component extracellular region biological_process membrane integral component of membrane uc009tkh.1 uc009tkh.2 uc009tkh.3 
ENSMUST00000048792.5 Bbln ENSMUST00000048792.5 bublin coiled coil protein (from RefSeq NM_198001.3) BBLN_MOUSE Bbln ENSMUST00000048792.1 ENSMUST00000048792.2 ENSMUST00000048792.3 ENSMUST00000048792.4 NM_198001 P58686 uc008jfk.1 uc008jfk.2 uc008jfk.3 uc008jfk.4 Essential for intermediate filament organization in intestinal cells, interacts with intermediate filament and regulates intestinal lumen morphology. Cell junction Cytoplasm, cytoskeleton Note=In the intestine, localizes subapically and at cell junctions. Interacts with intermediate filament (IF) proteins and localizes to the IF network in an IF-dependent manner (By similarity) (PubMed:33857431). In dividing cells, localizes to interpolar and kinetochore microtubules (By similarity). Belongs to the UPF0184 (EST00098) family. molecular_function cellular_component biological_process uc008jfk.1 uc008jfk.2 uc008jfk.3 uc008jfk.4 
ENSMUST00000048794.7 Hoxa5 ENSMUST00000048794.7 homeobox A5 (from RefSeq NM_010453.6) ENSMUST00000048794.1 ENSMUST00000048794.2 ENSMUST00000048794.3 ENSMUST00000048794.4 ENSMUST00000048794.5 ENSMUST00000048794.6 HXA5_MOUSE Hox-1.3 Hoxa-5 NM_010453 P09021 Q91VQ5 uc009byh.1 uc009byh.2 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. Forms a DNA-binding heterodimer with transcription factor PBX1. Nucleus. Expressed during embryogenesis and in adult kidney. Belongs to the Antp homeobox family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development morphogenesis of an epithelium respiratory system process DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated multicellular organism development pattern specification process respiratory gaseous exchange anterior/posterior pattern specification positive regulation of receptor biosynthetic process cell migration negative regulation of angiogenesis lung development thyroid gland development regulation of mammary gland epithelial cell proliferation multicellular organism growth positive regulation of apoptotic process sequence-specific DNA binding positive regulation of myeloid cell differentiation negative regulation of erythrocyte differentiation positive regulation of transcription from RNA polymerase II promoter lung alveolus development embryonic skeletal system morphogenesis embryonic skeletal system development bronchiole development trachea morphogenesis epithelial tube branching involved in lung morphogenesis lung goblet cell differentiation lobar bronchus epithelium development lung-associated mesenchyme development trachea cartilage morphogenesis cartilage morphogenesis intestinal epithelial cell maturation mesenchymal-epithelial cell signaling mammary gland epithelial cell differentiation mammary gland alveolus development cell-cell signaling involved in mammary gland development uc009byh.1 uc009byh.2 
ENSMUST00000048807.12 Mis12 ENSMUST00000048807.12 MIS12 kinetochore complex component (from RefSeq NM_025993.3) ENSMUST00000048807.1 ENSMUST00000048807.10 ENSMUST00000048807.11 ENSMUST00000048807.2 ENSMUST00000048807.3 ENSMUST00000048807.4 ENSMUST00000048807.5 ENSMUST00000048807.6 ENSMUST00000048807.7 ENSMUST00000048807.8 ENSMUST00000048807.9 MIS12_MOUSE Mis12 NM_025993 Q3V261 Q5QNU7 Q5QNU8 Q5QNU9 Q9CY25 uc007jxm.1 uc007jxm.2 uc007jxm.3 Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments. Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT. Chromosome, centromere, kinetochore Note=Associated with the kinetochore. Belongs to the mis12 family. mitotic sister chromatid segregation mitotic cell cycle MIS12/MIND type complex chromosome, centromeric region kinetochore condensed chromosome kinetochore nuclear MIS12/MIND complex molecular_function nucleus chromosome cell cycle chromosome segregation protein localization to kinetochore cell division attachment of mitotic spindle microtubules to kinetochore kinetochore assembly uc007jxm.1 uc007jxm.2 uc007jxm.3 
ENSMUST00000048824.9 Gm5617 ENSMUST00000048824.9 predicted gene 5617 (from RefSeq NM_001004191.3) CK071_MOUSE E9QNP8 ENSMUST00000048824.1 ENSMUST00000048824.2 ENSMUST00000048824.3 ENSMUST00000048824.4 ENSMUST00000048824.5 ENSMUST00000048824.6 ENSMUST00000048824.7 ENSMUST00000048824.8 NM_001004191 Q91VN2 uc009pii.1 uc009pii.2 uc009pii.3 uc009pii.4 uc009pii.5 molecular_function cellular_component biological_process uc009pii.1 uc009pii.2 uc009pii.3 uc009pii.4 uc009pii.5 
ENSMUST00000048860.9 Mreg ENSMUST00000048860.9 melanoregulin, transcript variant 2 (from RefSeq NM_001357488.2) Dsu ENSMUST00000048860.1 ENSMUST00000048860.2 ENSMUST00000048860.3 ENSMUST00000048860.4 ENSMUST00000048860.5 ENSMUST00000048860.6 ENSMUST00000048860.7 ENSMUST00000048860.8 Gm974 MREG_MOUSE NM_001357488 Q6NVG5 Wdt2 uc007bkg.1 uc007bkg.2 uc007bkg.3 uc007bkg.4 Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery (PubMed:22940130, PubMed:22275436, PubMed:30174147). Plays a role in hair pigmentation, a process that involves shedding of melanosome- containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes (PubMed:15550542, PubMed:3410303, PubMed:22753477). Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center (PubMed:22940130, PubMed:22275436). Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell (PubMed:19240024, PubMed:30174147). Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport (PubMed:30174147). Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5- bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (PubMed:19240024). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N- retinylidene-N-retinylethanolamine (A2E) in the eye (PubMed:19240024). May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (Probable). Identified in a complex with RILP and DCTN1; interacts directly with RILP, but does not interact directly with DCTN1 (PubMed:22275436). Interacts with PRPH2 (PubMed:17260955). Apical cell membrane ; Peripheral membrane protein Melanosome membrane ; Lipid- anchor Lysosome membrane ; Lipid- anchor Cytoplasmic vesicle membrane Note=Localizes to the inner segment and basal outer segment of rods in the retina. Detected in melanocytes (PubMed:15550542). Expressed in retina, in retinal pigment epithelium (at protein level) (PubMed:17260955, PubMed:19240024). Widely expressed with higher expression in skin, heart, liver, testis and thymus (PubMed:15550542). Detected in retina, in retinal pigment epithelium cells (PubMed:19240024). Detected throughout embryogenesis, from 7 dpc to 17 dpc. Palmitoylated. Palmitoylation is required to maintain the protein at the melanosome membrane. Dilute mice carry a hypomorphic allele of Myo5a, resulting in melanosome clustering in the center of the cell. This causes decreased light absorption and an apparent dilution of coat color. The hair color of mice that are deficient for both Myo5a and Mreg appears nearly normal, but the abnormal clustering of the melanosomes persists (PubMed:15550542, PubMed:3410303, PubMed:22753477). Likewise, mice deficient for Rab27a or Mreg have a gray coat, while mice deficient for Mreg and Rab27a, or Mreg and Mlph, have a hair coat that appears nearly black (PubMed:3410303). In spite of melanosome clustering, shedding of melanosome-containing vesicles and their uptake by adjacent keratinocytes is restored in mice that are deficient for both Myo5a and Mreg (PubMed:22753477). RNAi-mediated knockdown of Mreg in cultured Rab27a-deficient melanocytes restores normal melanosome location at the cell periphery. In cultured wild-type melanocytes melanosomes are dispersed at the cell periphery, and RNAi- mediated knockdown of Mreg has no effect on melanosome location (PubMed:22275436). In mice lacking Mreg, the number of phagosomes in retinal pigment epithelial cells displays a normal, rapid increase after the onset of light, but then decreases much more slowly than in wild-type (PubMed:19240024). Eyecups from 9 and 12 month old mutant mice display increased levels of the lipofuscin component N- retinylidene-N-retinylethanolamine (A2E) (PubMed:19240024). Belongs to the melanoregulin family. protein binding lysosome lysosomal membrane plasma membrane lipid binding membrane apical plasma membrane melanocyte differentiation cytoplasmic vesicle membrane intrinsic component of organelle membrane cytoplasmic vesicle late endosome membrane melanosome localization melanosome transport macromolecular complex melanosome membrane phosphatidylinositol binding melanosome pigmentation developmental pigmentation minus-end-directed organelle transport along microtubule phagosome maturation uc007bkg.1 uc007bkg.2 uc007bkg.3 uc007bkg.4 
ENSMUST00000048892.14 Icmt ENSMUST00000048892.14 isoprenylcysteine carboxyl methyltransferase, transcript variant 7 (from RefSeq NR_161307.1) ENSMUST00000048892.1 ENSMUST00000048892.10 ENSMUST00000048892.11 ENSMUST00000048892.12 ENSMUST00000048892.13 ENSMUST00000048892.2 ENSMUST00000048892.3 ENSMUST00000048892.4 ENSMUST00000048892.5 ENSMUST00000048892.6 ENSMUST00000048892.7 ENSMUST00000048892.8 ENSMUST00000048892.9 Icmt NR_161307 Q3U4N2 Q3U4N2_MOUSE uc008wad.1 uc008wad.2 uc008wad.3 uc008wad.4 Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. Reaction=[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S- adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L- cysteine methyl ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:21672, Rhea:RHEA-COMP:12125, Rhea:RHEA-COMP:12126, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90510, ChEBI:CHEBI:90511; EC=2.1.1.100; Evidence= Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. Lacks conserved residue(s) required for the propagation of feature annotation. protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane C-terminal protein methylation methyltransferase activity membrane integral component of membrane transferase activity methylation uc008wad.1 uc008wad.2 uc008wad.3 uc008wad.4 
ENSMUST00000048893.4 1700013G24Rik ENSMUST00000048893.4 RIKEN cDNA 1700013G24 gene (from RefSeq NM_027063.2) 1700013G24Rik A2A9V0 ENSMUST00000048893.1 ENSMUST00000048893.2 ENSMUST00000048893.3 NM_027063 Q9DAC6 Q9DAC6_MOUSE uc008vjb.1 uc008vjb.2 uc008vjb.3 molecular_function cellular_component biological_process uc008vjb.1 uc008vjb.2 uc008vjb.3 
ENSMUST00000048898.17 Mtmr7 ENSMUST00000048898.17 myotubularin related protein 7, transcript variant 1 (from RefSeq NM_001040699.2) ENSMUST00000048898.1 ENSMUST00000048898.10 ENSMUST00000048898.11 ENSMUST00000048898.12 ENSMUST00000048898.13 ENSMUST00000048898.14 ENSMUST00000048898.15 ENSMUST00000048898.16 ENSMUST00000048898.2 ENSMUST00000048898.3 ENSMUST00000048898.4 ENSMUST00000048898.5 ENSMUST00000048898.6 ENSMUST00000048898.7 ENSMUST00000048898.8 ENSMUST00000048898.9 MTMR7_MOUSE NM_001040699 Q8C4J6 Q9Z2C9 uc009lmz.1 uc009lmz.2 uc009lmz.3 Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3- bisphosphate (Ins(1,3)P2). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3- phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64; Evidence=; Reaction=1D-myo-inositol 1,3-bisphosphate + H2O = 1D-myo-inositol 1- phosphate + phosphate; Xref=Rhea:RHEA:57840, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58433, ChEBI:CHEBI:83242; Evidence=; Interaction with MTMR9 increases phosphatase activity. Kinetic parameters: KM=57 uM for inositol 1,3-bisphosphate (at pH 6 and in presence of MTMR9) ; Vmax=7.2 umol/min/mg enzyme (at pH 6 and in presence of MTMR9) ; Heterodimer (via C-terminus) with MTMR9 (via coiled coil domain); the interaction enhances MTMR7 catalytic activity (PubMed:12890864). Does not homodimerize (PubMed:12890864). Interacts with RAB1B (in GDP-bound form) (PubMed:23188820). Cytoplasm Endomembrane system ; Peripheral membrane protein ; Cytoplasmic side Note=May partially localize to endosomes and/or the Golgi apparatus. Highly expressed in brain (at protein level). Expressed at low levels in liver, kidney and testis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. phosphatidylinositol-3-phosphatase activity protein tyrosine phosphatase activity protein binding cytoplasm cytosol endomembrane system membrane dephosphorylation inositol bisphosphate phosphatase activity hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation phosphatidylinositol phosphate phosphatase activity uc009lmz.1 uc009lmz.2 uc009lmz.3 
ENSMUST00000048914.8 Mrpl34 ENSMUST00000048914.8 mitochondrial ribosomal protein L34 (from RefSeq NM_053162.2) ENSMUST00000048914.1 ENSMUST00000048914.2 ENSMUST00000048914.3 ENSMUST00000048914.4 ENSMUST00000048914.5 ENSMUST00000048914.6 ENSMUST00000048914.7 NM_053162 Q3TDJ8 Q99N91 RM34_MOUSE uc009mdh.1 uc009mdh.2 uc009mdh.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the bacterial ribosomal protein bL34 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation uc009mdh.1 uc009mdh.2 uc009mdh.3 
ENSMUST00000048921.13 4930433N12Rik ENSMUST00000048921.13 4930433N12Rik (from geneSymbol) AK015306 ENSMUST00000048921.1 ENSMUST00000048921.10 ENSMUST00000048921.11 ENSMUST00000048921.12 ENSMUST00000048921.2 ENSMUST00000048921.3 ENSMUST00000048921.4 ENSMUST00000048921.5 ENSMUST00000048921.6 ENSMUST00000048921.7 ENSMUST00000048921.8 ENSMUST00000048921.9 uc292egb.1 uc292egb.2 uc292egb.1 uc292egb.2 
ENSMUST00000048923.7 Spred3 ENSMUST00000048923.7 sprouty-related EVH1 domain containing 3 (from RefSeq NM_182927.3) A0A0R4J0K0 A0A0R4J0K0_MOUSE ENSMUST00000048923.1 ENSMUST00000048923.2 ENSMUST00000048923.3 ENSMUST00000048923.4 ENSMUST00000048923.5 ENSMUST00000048923.6 NM_182927 Spred3 uc009gax.1 uc009gax.2 multicellular organism development regulation of signal transduction membrane uc009gax.1 uc009gax.2 
ENSMUST00000048934.15 Tbr1 ENSMUST00000048934.15 T-box brain transcription factor 1, transcript variant 1 (from RefSeq NM_009322.4) ENSMUST00000048934.1 ENSMUST00000048934.10 ENSMUST00000048934.11 ENSMUST00000048934.12 ENSMUST00000048934.13 ENSMUST00000048934.14 ENSMUST00000048934.2 ENSMUST00000048934.3 ENSMUST00000048934.4 ENSMUST00000048934.5 ENSMUST00000048934.6 ENSMUST00000048934.7 ENSMUST00000048934.8 ENSMUST00000048934.9 NM_009322 Q64336 Q7TSY9 TBR1_MOUSE uc008jvd.1 uc008jvd.2 uc008jvd.3 Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:9883721, PubMed:11239428, PubMed:21285371). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (PubMed:21285371). Homodimer (By similarity). Part of a complex containing CASK, TBR1 and TSPYL2; may modulate gene expression in response to neuronal synaptic activity (PubMed:15066269). Forms homodimers (By similarity). Interacts with FOXP2 (By similarity). Interacts with FOXP1 (By similarity). Interacts with BCL11A (By similarity). Nucleus Expressed in the developing and adult cortex (PubMed:11239428). Expressed in the olfactory bulbs (PubMed:9883721). First detected around day 10 of embryonic development in the preplate, at day 12.5, in the cortical plate and intermediate zone, and from day 16.5 to 18.5, in a rostro-caudal gradient in the subplate. In the thalamus, expression is first observed at postnatal stage, P7, and weak expression continues in later postnatal and adult stages. Homozygous mutant mice do not nurse and die between postnatal days 1 and 3 (PubMed:9883721, PubMed:11239428). Brains are smaller than those of heterozygous or wild-type littermates, olfactory bulbs are small and olfactory bulb projection neurons are absent (PubMed:9883721). Mutant mice show severe defects of cortical development (PubMed:11239428). negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding conditioned taste aversion cell fate specification heart looping DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated specification of animal organ identity regulation of gene expression regulation of neuron projection development protein kinase binding amygdala development commitment of neuronal cell to specific neuron type in forebrain cerebral cortex development neuron differentiation hindbrain development identical protein binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of axon guidance uc008jvd.1 uc008jvd.2 uc008jvd.3 
ENSMUST00000048935.6 Dmrt3 ENSMUST00000048935.6 doublesex and mab-3 related transcription factor 3 (from RefSeq NM_177360.3) DMRT3_MOUSE ENSMUST00000048935.1 ENSMUST00000048935.2 ENSMUST00000048935.3 ENSMUST00000048935.4 ENSMUST00000048935.5 NM_177360 Q80WT2 Q8CGX1 uc008hbk.1 uc008hbk.2 uc008hbk.3 uc008hbk.4 uc008hbk.5 Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development. Nucleus Expressed in the ventral spinal cord, in a restrical population of neurons migrating ventrically in the developing spinal cord at 11.5 dpc. Expressed at 14.5 dpc in testis, kidney and bladder. Expression drops at 13.5 dpc in female gonads and is not detected at 15.5 dpc while it is expressed by Sertoli cells in testis. DMA domain interacts with ubiquitin. Significantly increase of stride length and extension movements in all limbs. Mice have major difficulties running at higher velocities. In water, mice spend less time swimming and showed frequent twitching limb movements. DMRT3 is a marker for a subset of spinal cord neurons (dI6). Belongs to the DMRT family. Name=Protein Spotlight; Note=A gait on the wildside - Issue 154 of November 2013; URL="https://web.expasy.org/spotlight/back_issues/154/"; DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development sex differentiation adult walking behavior transmission of nerve impulse ventral spinal cord interneuron specification cell differentiation regulation of odontogenesis of dentin-containing tooth sequence-specific DNA binding male sex differentiation metal ion binding protein heterodimerization activity uc008hbk.1 uc008hbk.2 uc008hbk.3 uc008hbk.4 uc008hbk.5 
ENSMUST00000048937.6 Leo1 ENSMUST00000048937.6 Leo1, Paf1/RNA polymerase II complex component (from RefSeq NM_001039522.1) E9QPK8 ENSMUST00000048937.1 ENSMUST00000048937.2 ENSMUST00000048937.3 ENSMUST00000048937.4 ENSMUST00000048937.5 Gm185 LEO1_MOUSE NM_001039522 Q5XJE5 Q640R1 uc009qsh.1 uc009qsh.2 uc009qsh.3 Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling (By similarity). Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and SKIC8. The PAF1 complex interacts with PHF5A (PubMed:27749823). Interacts with TCEA1, SUPT5H and CTNNB1 (By similarity). Interacts with SETD5 (PubMed:27864380). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5XJE5-1; Sequence=Displayed; Name=2; IsoId=Q5XJE5-2; Sequence=VSP_020054, VSP_020055; Belongs to the LEO1 family. fibrillar center endodermal cell fate commitment protein binding nucleus nucleoplasm centrosome transcription elongation from RNA polymerase II promoter mRNA polyadenylation histone monoubiquitination Wnt signaling pathway histone modification Cdc73/Paf1 complex stem cell population maintenance positive regulation of mRNA 3'-end processing positive regulation of transcription elongation from RNA polymerase II promoter histone H2B ubiquitination negative regulation of myeloid cell differentiation positive regulation of transcription from RNA polymerase II promoter RNA polymerase II C-terminal domain phosphoserine binding uc009qsh.1 uc009qsh.2 uc009qsh.3 
ENSMUST00000048941.14 Capn8 ENSMUST00000048941.14 calpain 8, transcript variant 1 (from RefSeq NM_130890.2) A0A0R4J0K6 A0A0R4J0K6_MOUSE Capn8 ENSMUST00000048941.1 ENSMUST00000048941.10 ENSMUST00000048941.11 ENSMUST00000048941.12 ENSMUST00000048941.13 ENSMUST00000048941.2 ENSMUST00000048941.3 ENSMUST00000048941.4 ENSMUST00000048941.5 ENSMUST00000048941.6 ENSMUST00000048941.7 ENSMUST00000048941.8 ENSMUST00000048941.9 NM_130890 uc007dyi.1 uc007dyi.2 uc007dyi.3 uc007dyi.4 Belongs to the peptidase C2 family. calcium-dependent cysteine-type endopeptidase activity calcium ion binding proteolysis digestion peptidase activity cysteine-type peptidase activity hydrolase activity uc007dyi.1 uc007dyi.2 uc007dyi.3 uc007dyi.4 
ENSMUST00000048945.6 Klk1b26 ENSMUST00000048945.6 kallikrein 1-related petidase b26 (from RefSeq NM_010644.3) B9EI06 ENSMUST00000048945.1 ENSMUST00000048945.2 ENSMUST00000048945.3 ENSMUST00000048945.4 ENSMUST00000048945.5 K1B26_MOUSE Klk-26 Klk26 NM_010644 P00753 P00754 P36369 uc009gof.1 uc009gof.2 uc009gof.3 uc009gof.4 uc009gof.5 uc009gof.6 This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. The kallikrein genes are present in a large gene cluster on chromosome 7. The encoded preproprotein is proteolytically processed to generate a mature protein product. Expression of this gene in the submandibular gland is sexually dimorphic likely due to both transcriptional and post-transcriptional regulation. This gene is thought to be distinct from the Egfbp2 gene (Gene ID: 13647), with which it shares 98% identity (PMIDs: 1959648, 9685728), however, it is not clear if both genes are present in all strains of mice. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: K01831.1, BC138704.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Prorenin-converting enzyme cleaves mouse REN-2 prorenin at a dibasic site to yield mature renin. Reaction=Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl- bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|- Xaa.; EC=3.4.21.35; Belongs to the peptidase S1 family. Kallikrein subfamily. brain renin-angiotensin system regulation of systemic arterial blood pressure endopeptidase activity serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides secretory granule zymogen activation macromolecular complex uc009gof.1 uc009gof.2 uc009gof.3 uc009gof.4 uc009gof.5 uc009gof.6 
ENSMUST00000048946.7 Card19 ENSMUST00000048946.7 caspase recruitment domain family, member 19, transcript variant 1 (from RefSeq NM_026738.3) CAR19_MOUSE Card19 ENSMUST00000048946.1 ENSMUST00000048946.2 ENSMUST00000048946.3 ENSMUST00000048946.4 ENSMUST00000048946.5 ENSMUST00000048946.6 NM_026738 Q3U3Y9 Q9D1I2 uc007qiy.1 uc007qiy.2 Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. Associates with BCL10 by CARD-CARD interaction. Endoplasmic reticulum membrane ; Single-pass membrane protein Mitochondrion membrane ; Single-pass membrane protein. molecular_function mitochondrion endoplasmic reticulum endoplasmic reticulum membrane biological_process membrane integral component of membrane mitochondrial membrane regulation of apoptotic process uc007qiy.1 uc007qiy.2 
ENSMUST00000048957.11 Ptpn13 ENSMUST00000048957.11 protein tyrosine phosphatase, non-receptor type 13 (from RefSeq NM_011204.2) ENSMUST00000048957.1 ENSMUST00000048957.10 ENSMUST00000048957.2 ENSMUST00000048957.3 ENSMUST00000048957.4 ENSMUST00000048957.5 ENSMUST00000048957.6 ENSMUST00000048957.7 ENSMUST00000048957.8 ENSMUST00000048957.9 G5E8B1 G5E8B1_MOUSE NM_011204 Ptpn13 uc008yjl.1 uc008yjl.2 uc008yjl.3 Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Cytoplasm, cytoskeleton Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. negative regulation of protein phosphorylation phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm cytoskeleton plasma membrane protein dephosphorylation regulation of phosphatidylinositol 3-kinase signaling dephosphorylation hydrolase activity phosphatase activity lamellipodium peptidyl-tyrosine dephosphorylation phosphatidylinositol 3-kinase regulatory subunit binding neuron projection cell body uc008yjl.1 uc008yjl.2 uc008yjl.3 
ENSMUST00000048959.5 Cyp2c54 ENSMUST00000048959.5 cytochrome P450, family 2, subfamily c, polypeptide 54 (from RefSeq NM_206537.2) CP254_MOUSE Cyp2c54 ENSMUST00000048959.1 ENSMUST00000048959.2 ENSMUST00000048959.3 ENSMUST00000048959.4 NM_206537 Q6XVG2 uc012bln.1 uc012bln.2 uc012bln.3 uc012bln.4 Metabolizes arachidonic acid mainly to 12- hydroxyeicosatetraenoic acid (HETE). Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Expressed in liver. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen arachidonic acid metabolic process epoxygenase P450 pathway heme binding organelle membrane exogenous drug catabolic process intracellular membrane-bounded organelle linoleic acid metabolic process metal ion binding oxidation-reduction process aromatase activity linoleic acid epoxygenase activity uc012bln.1 uc012bln.2 uc012bln.3 uc012bln.4 
ENSMUST00000048962.4 Kif4 ENSMUST00000048962.4 kinesin family member 4 (from RefSeq NM_008446.3) ENSMUST00000048962.1 ENSMUST00000048962.2 ENSMUST00000048962.3 KIF4_MOUSE Kif4a Kns4 NM_008446 P33174 Q80YP3 uc009twh.1 uc009twh.2 uc009twh.3 uc009twh.4 Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (By similarity). Required for mitotic chromosomal positioning and bipolar spindle stabilization. Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster (By similarity). In the presence of oxygen, the [4Fe-4S] cluster may be converted to [2Fe-2S] (By similarity). ; Nucleus Chromosome Cytoplasm, cytoskeleton Expressed in pyramidal cells in juvenile hippocampus, granular cells in juvenile cerebellar cortex and in adult spleen. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily. nucleotide binding mitotic cytokinesis DNA binding microtubule motor activity ATP binding nucleus nucleoplasm chromosome cytoplasm cytosol cytoskeleton kinesin complex microtubule microtubule-based movement mitotic spindle organization microtubule binding ATPase activity midbody intercellular bridge mitotic spindle midzone assembly uc009twh.1 uc009twh.2 uc009twh.3 uc009twh.4 
ENSMUST00000048965.5 Gm9752 ENSMUST00000048965.5 predicted gene 9752, transcript variant 5 (from RefSeq NR_188898.1) ENSMUST00000048965.1 ENSMUST00000048965.2 ENSMUST00000048965.3 ENSMUST00000048965.4 NR_188898 uc288qfb.1 uc288qfb.2 uc288qfb.1 uc288qfb.2 
ENSMUST00000048966.7 Tcf20 ENSMUST00000048966.7 transcription factor 20, transcript variant 2 (from RefSeq NM_013836.3) B9EHJ7 ENSMUST00000048966.1 ENSMUST00000048966.2 ENSMUST00000048966.3 ENSMUST00000048966.4 ENSMUST00000048966.5 ENSMUST00000048966.6 NM_013836 Q60792 Q9EPQ8 Spbp TCF20_MOUSE uc007wzp.1 uc007wzp.2 uc007wzp.3 uc007wzp.4 uc007wzp.5 uc007wzp.6 Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. Homodimer (Probable). Interacts with RNF4 and JUN. Binds to the regulatory region of MMP3. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EPQ8-1; Sequence=Displayed; Name=2; IsoId=Q9EPQ8-2; Sequence=VSP_003986; Expressed in brain, lung, liver, kidney and testes. Isoform 2 is exclusively expressed at 7-11 days of development. Isoform 1 is found only at low levels in 15-17 days embryos. The atypical PHD domain functions as a negative modulator of cofactor binding. Sequence=AAA86495.1; Type=Frameshift; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm nuclear body transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc007wzp.1 uc007wzp.2 uc007wzp.3 uc007wzp.4 uc007wzp.5 uc007wzp.6 
ENSMUST00000048967.9 Cpe ENSMUST00000048967.9 carboxypeptidase E (from RefSeq NM_013494.4) Cpe ENSMUST00000048967.1 ENSMUST00000048967.2 ENSMUST00000048967.3 ENSMUST00000048967.4 ENSMUST00000048967.5 ENSMUST00000048967.6 ENSMUST00000048967.7 ENSMUST00000048967.8 NM_013494 Q543R4 Q543R4_MOUSE uc009luw.1 uc009luw.2 uc009luw.3 uc009luw.4 uc009luw.5 uc009luw.6 This gene encodes carboxypeptidase E, a prohormone-processing exopeptidase found in secretory granules of endocrine and neuroendocrine cells. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that cleaves the C-terminal basic residues of protein substrates. A missense mutation in this gene is responsible for the obesity phenotype in a mouse model known as the 'fat mouse.' Mice lacking the functional product of this gene exhibit impaired processing of multiple peptide hormones such as proinsulin, prodynorphin, proneurotensin, promelanin-concentrating hormone and pro-opiomelanocortin. [provided by RefSeq, Jan 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010197.1, SRR1660811.112356.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. Reaction=Release of C-terminal arginine or lysine residues from polypeptides.; EC=3.4.17.10; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Interacts with Secretogranin III/SCG3. Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein Membrane ; Peripheral membrane protein Secreted Belongs to the peptidase M14 family. cardiac left ventricle morphogenesis metallocarboxypeptidase activity Golgi apparatus proteolysis zinc ion binding Wnt signaling pathway neurexin family protein binding cell adhesion molecule binding protein localization to membrane uc009luw.1 uc009luw.2 uc009luw.3 uc009luw.4 uc009luw.5 uc009luw.6 
ENSMUST00000048976.8 Gucy1a1 ENSMUST00000048976.8 guanylate cyclase 1, soluble, alpha 1, transcript variant 1 (from RefSeq NM_021896.6) ENSMUST00000048976.1 ENSMUST00000048976.2 ENSMUST00000048976.3 ENSMUST00000048976.4 ENSMUST00000048976.5 ENSMUST00000048976.6 ENSMUST00000048976.7 GCYA1_MOUSE Gucy1a3 NM_021896 Q6GTG0 Q9DBQ3 Q9ERL9 uc008pou.1 uc008pou.2 uc008pou.3 uc008pou.4 Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Has also activity with Mn(2+) (in vitro). ; Activated by nitric oxide in the presence of magnesium or manganese ions. The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1B1. Cytoplasm There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding guanylate cyclase activity GTP binding cytoplasm cGMP biosynthetic process guanylate cyclase complex, soluble regulation of blood pressure cyclic nucleotide biosynthetic process positive regulation of nitric oxide mediated signal transduction lyase activity phosphorus-oxygen lyase activity heme binding macromolecular complex intracellular signal transduction ion binding protein heterodimerization activity response to defense-related host nitric oxide production relaxation of vascular smooth muscle retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission glutamatergic synapse GABA-ergic synapse adenylate cyclase activity cytidylate cyclase activity uc008pou.1 uc008pou.2 uc008pou.3 uc008pou.4 
ENSMUST00000048977.16 Greb1l ENSMUST00000048977.16 growth regulation by estrogen in breast cancer-like (from RefSeq NM_001083628.1) B9EJV3 ENSMUST00000048977.1 ENSMUST00000048977.10 ENSMUST00000048977.11 ENSMUST00000048977.12 ENSMUST00000048977.13 ENSMUST00000048977.14 ENSMUST00000048977.15 ENSMUST00000048977.2 ENSMUST00000048977.3 ENSMUST00000048977.4 ENSMUST00000048977.5 ENSMUST00000048977.6 ENSMUST00000048977.7 ENSMUST00000048977.8 ENSMUST00000048977.9 GRB1L_MOUSE Kiaa4095 NM_001083628 Q5DTN6 uc008eat.1 uc008eat.2 uc008eat.3 Plays a major role in early metanephros and genital development. Membrane ; Single-pass membrane protein Expressed in the inner ear, with a high presence in the spiral ganglia, cochlear nerve bundles, and hair cells. At 15.5 dpc, expressed in kidney, ureter and bladder (PubMed:29100090). At 16.0 dpc, strong expression in the liver, thymus, intestine, kidney, and brain. In the brain, high levels in the ventricular zone and in the neopallial cortex. In the kidney, highest levels in the nephrogenic zone located in the cortical region of the kidney. Also observed in epithelial cells of the differentiating renal tubules. At P0, strong expression in the nephrogenic zone (PubMed:29100091). In the inner ear, prominent expression is observed between 13 and 16 dpc (PubMed:29955957). Embryonic lethal at the homozygous state. At 13.5 dpc, all homozygous embryos are significantly smaller compared to wild- type and heterozygous littermates and present with exencephaly. Male and female embryos lack kidney and show absence of Wolffian and Muellerian ducts, respectively. However, mesonephric tubules are consistently observed. Some potential remnants of ureteric bud are present in most mutant embryos. In male mutant embryos, the gonads are severely affected, being small and with poorly organized sex-cords compared to wild-type littermates. Mutant embryos also show cardiac morphogenesis defects with superimposed ventricles. Belongs to the GREB1 family. metanephros development branching involved in ureteric bud morphogenesis kidney development cardiac ventricle development molecular_function cellular_component multicellular organism development membrane integral component of membrane male genitalia development uterus development epithelial tube morphogenesis paramesonephric duct development mesonephric duct development uc008eat.1 uc008eat.2 uc008eat.3 
ENSMUST00000048982.11 Prickle1 ENSMUST00000048982.11 prickle planar cell polarity protein 1, transcript variant 1 (from RefSeq NM_001033217.5) ENSMUST00000048982.1 ENSMUST00000048982.10 ENSMUST00000048982.2 ENSMUST00000048982.3 ENSMUST00000048982.4 ENSMUST00000048982.5 ENSMUST00000048982.6 ENSMUST00000048982.7 ENSMUST00000048982.8 ENSMUST00000048982.9 NM_001033217 PRIC1_MOUSE Q3U5C7 uc007xjb.1 uc007xjb.2 Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure (By similarity). Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor (By similarity). Interacts with REST. Q3U5C7; Q8VIG1: Rest; NbExp=2; IntAct=EBI-27099745, EBI-2312802; Nucleus membrane Cytoplasm, cytosol Note=A smaller amount is detected in the cytosol. Belongs to the prickle / espinas / testin family. neural tube closure protein binding nucleus cytoplasm cytosol protein import into nucleus transcription factor binding zinc ion binding membrane positive regulation of protein ubiquitination nuclear membrane positive regulation of proteasomal ubiquitin-dependent protein catabolic process aorta development negative regulation of transcription, DNA-templated metal ion binding coronary vasculature development negative regulation of canonical Wnt signaling pathway negative regulation of cardiac muscle cell myoblast differentiation uc007xjb.1 uc007xjb.2 
ENSMUST00000048988.14 Znfx1 ENSMUST00000048988.14 zinc finger, NFX1-type containing 1, transcript variant 4 (from RefSeq NM_001424676.1) A2A5R3 ENSMUST00000048988.1 ENSMUST00000048988.10 ENSMUST00000048988.11 ENSMUST00000048988.12 ENSMUST00000048988.13 ENSMUST00000048988.2 ENSMUST00000048988.3 ENSMUST00000048988.4 ENSMUST00000048988.5 ENSMUST00000048988.6 ENSMUST00000048988.7 ENSMUST00000048988.8 ENSMUST00000048988.9 NM_001424676 Q3U016 Q3UD71 Q3UEZ0 Q8R151 ZNFX1_MOUSE Znfx1 uc008nzc.1 uc008nzc.2 uc008nzc.3 uc008nzc.4 RNA-binding protein that initiates the antiviral response and is required to restrict the replication of RNA viruses (PubMed:31685995). Acts as a double-stranded RNA (dsRNA) sensor that recognizes viral RNA and then interacts with MAVS to initiate the type I interferon response (PubMed:31685995). Also required for immunity against some bacteria, such as mycobacteria (By similarity). Interacts with MAVS. Mitochondrion outer membrane Cytoplasm, Stress granule By interferons (IFNs) (PubMed:31685995). Expression is induced upon viral infection (PubMed:31685995). Mice are viable without obvious physiological or behavioral abnormalities (PubMed:31685995). They however display impaired innate immune responses against RNA virus infection by producing less type I interferons (IFNs) (PubMed:31685995). Belongs to the ZNFX1 family. Sequence=AAH25488.1; Type=Erroneous initiation; Evidence=; Sequence=BAE34040.1; Type=Erroneous initiation; Evidence=; chromosome, centromeric region transcription factor activity, sequence-specific DNA binding RNA binding nucleus regulation of transcription, DNA-templated zinc ion binding chromatin silencing at centromere chromatin silencing by small RNA nuclear RNA-directed RNA polymerase complex metal ion binding uc008nzc.1 uc008nzc.2 uc008nzc.3 uc008nzc.4 
ENSMUST00000048993.12 Polr3g ENSMUST00000048993.12 polymerase (RNA) III (DNA directed) polypeptide G (from RefSeq NM_001081176.1) ENSMUST00000048993.1 ENSMUST00000048993.10 ENSMUST00000048993.11 ENSMUST00000048993.2 ENSMUST00000048993.3 ENSMUST00000048993.4 ENSMUST00000048993.5 ENSMUST00000048993.6 ENSMUST00000048993.7 ENSMUST00000048993.8 ENSMUST00000048993.9 NM_001081176 Q6NXY9 Q8K0W5 Q9CV05 RPC7_MOUSE uc007rhy.1 uc007rhy.2 uc007rhy.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (By similarity). Acts as a long tether that bridges POLR3C/RPC3- POLR3F/RPC6-POLR3G/RPC7 heterotrimer and the mobile stalk of Pol III, coordinating the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state. Pol III exists as two alternative complexes defined by the mutually exclusive incorporation of subunit POLR3G/RPC7alpha or POLR3GL/RPC7beta. POLR3G/RPC7alpha modulates Pol III transcriptome by specifically enhancing the transcription of snaR-A non-coding RNAs. At resting state, occupies the active site of apo Pol III and keeps Pol III in an autoinhibitory mode, preventing non-specific transcription (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity). Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3- POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination (By similarity). Directly interacts with POLR3C/RPC62. Also found in a trimeric complex with POLR3C/RPC3 and POLR3GL (By similarity). Nucleus Cytoplasm Note=In zygotes and the 2-cell stage embryos, mainly in the cytoplasm. Starts to localize to the nucleus in the 8-16 cell stage embryo and early blastocysts. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NXY9-1; Sequence=Displayed; Name=2; IsoId=Q6NXY9-2; Sequence=VSP_012672, VSP_012673; Expressed at low levels in the liver. Not detectable in unfertilized oocytes. First detected in zygotes and the 2-cell stage embryos. Expressed until at least the early blastocyst stage. Belongs to the eukaryotic RPC7 RNA polymerase subunit family. immune system process DNA-directed 5'-3' RNA polymerase activity nucleus DNA-directed RNA polymerase III complex cytoplasm transcription from RNA polymerase III promoter cell proliferation positive regulation of interferon-beta production innate immune response positive regulation of innate immune response defense response to virus nuclear chromatin uc007rhy.1 uc007rhy.2 uc007rhy.3 
ENSMUST00000048994.7 Nfkbil1 ENSMUST00000048994.7 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1, transcript variant 1 (from RefSeq NM_010909.5) ENSMUST00000048994.1 ENSMUST00000048994.2 ENSMUST00000048994.3 ENSMUST00000048994.4 ENSMUST00000048994.5 ENSMUST00000048994.6 IKBL1_MOUSE Ikbl NM_010909 O88995 Q91X16 Q9R1Y3 uc008cgv.1 uc008cgv.2 uc008cgv.3 Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (By similarity). Interacts with CACTIN (via N-terminal domain); the interaction occurs in a pro-inflammatory-independent manner. Nucleus Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus (By similarity). High expression found in heart muscle, liver, kidney and skin. Not detected in spleen, lung and brain. molecular_function nucleus cytosol I-kappaB kinase/NF-kappaB signaling negative regulation of lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity negative regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway cellular response to lipopolysaccharide uc008cgv.1 uc008cgv.2 uc008cgv.3 
ENSMUST00000049005.15 Bmpr1a ENSMUST00000049005.15 bone morphogenetic protein receptor, type 1A (from RefSeq NM_009758.4) Bmpr1a ENSMUST00000049005.1 ENSMUST00000049005.10 ENSMUST00000049005.11 ENSMUST00000049005.12 ENSMUST00000049005.13 ENSMUST00000049005.14 ENSMUST00000049005.2 ENSMUST00000049005.3 ENSMUST00000049005.4 ENSMUST00000049005.5 ENSMUST00000049005.6 ENSMUST00000049005.7 ENSMUST00000049005.8 ENSMUST00000049005.9 NM_009758 Q53Z43 Q53Z43_MOUSE uc007taw.1 uc007taw.2 uc007taw.3 Membrane ; Single- pass type I membrane protein Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity ATP binding plasma membrane caveola protein phosphorylation immune response transmembrane receptor protein serine/threonine kinase signaling pathway external side of plasma membrane positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of smooth muscle cell migration membrane integral component of membrane kinase activity phosphorylation transferase activity dendrite positive regulation of bone mineralization BMP signaling pathway protein homodimerization activity neuronal cell body positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter SMAD binding positive regulation of SMAD protein import into nucleus cellular response to BMP stimulus positive regulation of vascular smooth muscle cell proliferation uc007taw.1 uc007taw.2 uc007taw.3 
ENSMUST00000049009.7 Rad9b ENSMUST00000049009.7 RAD9 checkpoint clamp component B, transcript variant 1 (from RefSeq NM_144912.4) ENSMUST00000049009.1 ENSMUST00000049009.2 ENSMUST00000049009.3 ENSMUST00000049009.4 ENSMUST00000049009.5 ENSMUST00000049009.6 NM_144912 Q8VC54 Q8VC54_MOUSE Rad9b uc008zkz.1 uc008zkz.2 uc008zkz.3 Belongs to the rad9 family. DNA damage checkpoint DNA repair checkpoint clamp complex uc008zkz.1 uc008zkz.2 uc008zkz.3 
ENSMUST00000049020.9 Irgq ENSMUST00000049020.9 immunity-related GTPase family, Q (from RefSeq NM_153134.3) ENSMUST00000049020.1 ENSMUST00000049020.2 ENSMUST00000049020.3 ENSMUST00000049020.4 ENSMUST00000049020.5 ENSMUST00000049020.6 ENSMUST00000049020.7 ENSMUST00000049020.8 Fksg27 IRGQ_MOUSE Irgq1 NM_153134 Q7TNC7 Q8VIM9 uc009fpv.1 uc009fpv.2 uc009fpv.3 uc009fpv.4 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. molecular_function GTP binding cellular_component biological_process uc009fpv.1 uc009fpv.2 uc009fpv.3 uc009fpv.4 
ENSMUST00000049022.15 Ninj1 ENSMUST00000049022.15 ninjurin 1 (from RefSeq NM_013610.3) ENSMUST00000049022.1 ENSMUST00000049022.10 ENSMUST00000049022.11 ENSMUST00000049022.12 ENSMUST00000049022.13 ENSMUST00000049022.14 ENSMUST00000049022.2 ENSMUST00000049022.3 ENSMUST00000049022.4 ENSMUST00000049022.5 ENSMUST00000049022.6 ENSMUST00000049022.7 ENSMUST00000049022.8 ENSMUST00000049022.9 NM_013610 Ninj1 Q3TXT8 Q3TXT8_MOUSE uc007qiw.1 uc007qiw.2 uc007qiw.3 Membrane ; Multi- pass membrane protein Belongs to the ninjurin family. cell adhesion membrane integral component of membrane tissue regeneration uc007qiw.1 uc007qiw.2 uc007qiw.3 
ENSMUST00000049027.10 Slc26a9 ENSMUST00000049027.10 solute carrier family 26, member 9 (from RefSeq NM_177243.4) A0A0R4J0F7 A0A0R4J0F7_MOUSE ENSMUST00000049027.1 ENSMUST00000049027.2 ENSMUST00000049027.3 ENSMUST00000049027.4 ENSMUST00000049027.5 ENSMUST00000049027.6 ENSMUST00000049027.7 ENSMUST00000049027.8 ENSMUST00000049027.9 NM_177243 Slc26a9 uc007cns.1 uc007cns.2 uc007cns.3 Ion transporter that can act both as an ion channel and anion exchanger. Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane. Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane. Membrane ulti-pass membrane protein Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Lacks conserved residue(s) required for the propagation of feature annotation. chloride channel activity ion transport anion transport chloride transport secondary active sulfate transmembrane transporter activity sulfate transport cell surface positive regulation of gene expression sulfate transmembrane transporter activity anion:anion antiporter activity bicarbonate transport membrane integral component of membrane apical plasma membrane ATPase binding transmembrane transport anion transmembrane transport sulfate transmembrane transport chloride transmembrane transport uc007cns.1 uc007cns.2 uc007cns.3 
ENSMUST00000049031.6 Mindy2 ENSMUST00000049031.6 MINDY lysine 48 deubiquitinase 2, transcript variant 1 (from RefSeq NM_172772.2) ENSMUST00000049031.1 ENSMUST00000049031.2 ENSMUST00000049031.3 ENSMUST00000049031.4 ENSMUST00000049031.5 Fam63b Kiaa1164 MINY2_MOUSE NM_172772 Q571N1 Q6NSV8 Q6PDI6 Q7TML6 Q8BK25 Q8BL22 Q8BL47 Q8BZC1 uc009qon.1 uc009qon.2 Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Can also bind to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys- 33' and 'Lys-63'. May play a regulatory role at the level of protein turnover. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PDI6-1; Sequence=Displayed; Name=2; IsoId=Q6PDI6-2; Sequence=VSP_034720; Name=3; IsoId=Q6PDI6-3; Sequence=VSP_034721, VSP_034722; Belongs to the MINDY deubiquitinase family. FAM63 subfamily. Sequence=AAH69845.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC32709.1; Type=Frameshift; Evidence=; Sequence=BAD90344.1; Type=Erroneous initiation; Evidence=; thiol-dependent ubiquitin-specific protease activity nucleoplasm cytosol proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity cysteine-type carboxypeptidase activity K48-linked polyubiquitin binding thiol-dependent ubiquitinyl hydrolase activity K63-linked polyubiquitin binding protein K48-linked deubiquitination K11-linked polyubiquitin binding K6-linked polyubiquitin binding Lys48-specific deubiquitinase activity uc009qon.1 uc009qon.2 
ENSMUST00000049032.13 Gmeb2 ENSMUST00000049032.13 glucocorticoid modulatory element binding protein 2, transcript variant 5 (from RefSeq NR_185069.1) ENSMUST00000049032.1 ENSMUST00000049032.10 ENSMUST00000049032.11 ENSMUST00000049032.12 ENSMUST00000049032.2 ENSMUST00000049032.3 ENSMUST00000049032.4 ENSMUST00000049032.5 ENSMUST00000049032.6 ENSMUST00000049032.7 ENSMUST00000049032.8 ENSMUST00000049032.9 GMEB2_MOUSE NR_185069 P58929 Q6PCY0 uc008olr.1 uc008olr.2 uc008olr.3 Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity). Homodimer, and heterodimer of GMEB1 and GMEB2. Interacts with the glucocorticoid receptor (NR3C1). May interact with CREB-binding protein (CBP) (By similarity). Nucleus Cytoplasm Note=May be also cytoplasmic. RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription coactivator activity nucleus nucleoplasm cytoplasm cytosol regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of nucleic acid-templated transcription uc008olr.1 uc008olr.2 uc008olr.3 
ENSMUST00000049038.4 Sox30 ENSMUST00000049038.4 SRY (sex determining region Y)-box 30 (from RefSeq NM_173384.3) ENSMUST00000049038.1 ENSMUST00000049038.2 ENSMUST00000049038.3 NM_173384 Q8CGW4 SOX30_MOUSE uc011xtj.1 uc011xtj.2 uc011xtj.3 Acts both as a transcriptional activator and a repressor (PubMed:29866902, PubMed:29848638). Binds to the DNA sequence 5'-ACAAT- 3' and shows a preference for guanine residues surrounding this core motif (PubMed:29866902). Binds to its own promoter and activates its own transcription (PubMed:29866902, PubMed:29848638). Required to activate the expression of postmeiotic genes involved in spermiogenesis (PubMed:29866902, PubMed:29848638). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (By similarity). Interacts with CTNNB1, competitively inhibiting CTNNB1- TCF7L2/TCF4 interaction. Nucleus toplasm Note=Enriched at the chromocenter. Expressed in the lung (at protein level) (PubMed:29739711). Expressed in testes (at protein level) (PubMed:10359848, PubMed:29848638, PubMed:25609838). Expressed in preleptotene spermatocytes, round spermatids, and elongated spermatids in the testis (at protein level) (PubMed:29866902, PubMed:25609838). Expressed in pachytene spermatocytes during stages 3 to 8 of spermatogenesis (at protein level) (PubMed:29866902, PubMed:29848638, PubMed:25609838). Increased expression in diplotene spermatocytes at stage 9-11 and in metaphase spermatocytes or secondary spermatocytes at stage 12 (PubMed:29848638, PubMed:25609838). Expressed in ovaries (PubMed:29848638). Expressed in the testes at 13.5 dpc (PubMed:10359848, PubMed:29848638). Also expressed in the mesonephros, metanephros, brain, lung, heart and stomach at 13.5 dpc (PubMed:10359848). Expressed in the testes at 14.5 dpc (PubMed:29848638). Expressed in the ovary at 13.5 and 14.5 dpc (PubMed:29848638). Expressed weakly in the testes at postnatal day 14 (P14), strongly expressed from P21 onwards (PubMed:29866902). Expressed in the nucleus of pachytene spermatocytes in stages 5 to 6 of spermatogenesis (PubMed:29866902). Expressed in round spermatids and increased expression in pachytene spermatocytes in stages 7 to 8 of spermatogenesis (PubMed:29866902). Expressed in the nucleus of diplotene spermatocytes in stages 11 to 12 of spermatogenesis, however expression in the nuclei of spermatids is lost (PubMed:29866902). Induced in germline stem cells by retinoic acid. Knockout mice are viable, morphologically normal, but males are sterile (PubMed:29866902, PubMed:29848638). Male mice exhibit small testes and epididymis (PubMed:29848638). Multinuclear syncytia present in the seminiferous tubules, with degenerated multi- chromocenter round spermatids and multinucleated giant cells in the epididymis lumen (PubMed:29848638). Increased numbers of apoptotic cells in the testes and epididymis (PubMed:29848638). Increased expression of CTNNB1, MYC, CCND1, and MMP7 in lung cells (PubMed:29739711). Increase in diplotene spermatocytes in the testes, indicative of defects in the later stages of meiosis (PubMed:29866902). Developmental failure of the large nuclear docking acrosome to develop during the cap phase of spermiogenesis (PubMed:29866902, PubMed:29848638). In addition disruption of proacrosomic vesicle translocation during spermatid differentiation results in the absence of elongating spermatids and therefore viable sperm (PubMed:29866902). No effect on transcription or processing of piRNA precursors (PubMed:29866902). DNA binding nucleus spermatogenesis response to corticosteroid sequence-specific DNA binding uc011xtj.1 uc011xtj.2 uc011xtj.3 
ENSMUST00000049040.14 Bri3bp ENSMUST00000049040.14 Bri3 binding protein, transcript variant 1 (from RefSeq NM_029752.2) BRI3B_MOUSE Bri3bp ENSMUST00000049040.1 ENSMUST00000049040.10 ENSMUST00000049040.11 ENSMUST00000049040.12 ENSMUST00000049040.13 ENSMUST00000049040.2 ENSMUST00000049040.3 ENSMUST00000049040.4 ENSMUST00000049040.5 ENSMUST00000049040.6 ENSMUST00000049040.7 ENSMUST00000049040.8 ENSMUST00000049040.9 NM_029752 Q8BXP1 Q8BXV2 Q9CWE5 uc008zrr.1 uc008zrr.2 uc008zrr.3 Involved in tumorigenesis and may function by stabilizing p53/TP53. Interacts with LETMD1. Interacts with BRI3. Interacts with BRI3; the interaction is weak (By similarity). Interacts with TMEM238L (By similarity). Mitochondrion outer membrane ; Multi-pass membrane protein molecular_function mitochondrion mitochondrial outer membrane biological_process membrane integral component of membrane uc008zrr.1 uc008zrr.2 uc008zrr.3 
ENSMUST00000049052.4 Zfp747l1 ENSMUST00000049052.4 zinc finger protein 747 like 1 (from RefSeq NM_030226.3) 9130019O22Rik ENSMUST00000049052.1 ENSMUST00000049052.2 ENSMUST00000049052.3 G3X941 G3X941_MOUSE NM_030226 uc009jve.1 uc009jve.2 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009jve.1 uc009jve.2 
ENSMUST00000049053.9 Fam168a ENSMUST00000049053.9 family with sequence similarity 168, member A, transcript variant 2 (from RefSeq NM_178764.4) ENSMUST00000049053.1 ENSMUST00000049053.2 ENSMUST00000049053.3 ENSMUST00000049053.4 ENSMUST00000049053.5 ENSMUST00000049053.6 ENSMUST00000049053.7 ENSMUST00000049053.8 F168A_MOUSE Kiaa0280 NM_178764 Q3UVC2 Q80U50 Q8BGN7 Q8BGZ2 uc009inq.1 uc009inq.2 uc009inq.3 uc009inq.4 In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels. Interacts with POLB. Interacts with AKT1 and MT1X. May interact with FAM168B. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGZ2-1; Sequence=Displayed; Name=2; IsoId=Q8BGZ2-2; Sequence=VSP_010096; Belongs to the FAM168 family. molecular_function cellular_component positive regulation of base-excision repair uc009inq.1 uc009inq.2 uc009inq.3 uc009inq.4 
ENSMUST00000049057.5 Fam171a2 ENSMUST00000049057.5 family with sequence similarity 171, member A2 (from RefSeq NM_199200.2) A2A699 B7ZC48 ENSMUST00000049057.1 ENSMUST00000049057.2 ENSMUST00000049057.3 ENSMUST00000049057.4 F1712_MOUSE NM_199200 Q05CH6 Q6P2L1 uc007lrw.1 uc007lrw.2 uc007lrw.3 uc007lrw.4 Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2A699-1; Sequence=Displayed; Name=2; IsoId=A2A699-2; Sequence=VSP_032783; Belongs to the FAM171 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007lrw.1 uc007lrw.2 uc007lrw.3 uc007lrw.4 
ENSMUST00000049064.4 Rap2b ENSMUST00000049064.4 RAP2B, member of RAS oncogene family (from RefSeq NM_028712.4) ENSMUST00000049064.1 ENSMUST00000049064.2 ENSMUST00000049064.3 NM_028712 Q6ZWR0 Q6ZWR0_MOUSE Rap2b uc008pjl.1 uc008pjl.2 uc008pjl.3 Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Endosome membrane ; Lipid-anchor ; Cytoplasmic side Recycling endosome membrane ; Lipid- anchor ; Cytoplasmic side Palmitoylated. Belongs to the small GTPase superfamily. Ras family. nucleotide binding GTPase activity GTP binding cytosol plasma membrane bicellular tight junction signal transduction membrane GDP binding platelet activation Rap protein signal transduction cell-cell contact zone membrane raft extracellular exosome platelet aggregation uc008pjl.1 uc008pjl.2 uc008pjl.3 
ENSMUST00000049074.13 Ptprf ENSMUST00000049074.13 protein tyrosine phosphatase receptor type F (from RefSeq NM_011213.2) A2A8L5 ENSMUST00000049074.1 ENSMUST00000049074.10 ENSMUST00000049074.11 ENSMUST00000049074.12 ENSMUST00000049074.2 ENSMUST00000049074.3 ENSMUST00000049074.4 ENSMUST00000049074.5 ENSMUST00000049074.6 ENSMUST00000049074.7 ENSMUST00000049074.8 ENSMUST00000049074.9 Lar NM_011213 PTPRF_MOUSE Q6PG86 Q9EQ17 uc008ujq.1 uc008ujq.2 uc008ujq.3 Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Interacts with GRIP1. Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with PTPRF. Membrane ; Single-pass membrane protein Expressed in the cell of the T lineage but not in cells of any other hemopoietic lineage. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. negative regulation of cytokine-mediated signaling pathway phosphoprotein phosphatase activity protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity insulin receptor binding endosome plasma membrane protein dephosphorylation cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules nervous system development heparin binding negative regulation of cell proliferation regulation of neuron projection development membrane integral component of membrane dephosphorylation cell migration hydrolase activity phosphatase activity growth cone receptor tyrosine kinase binding neuron projection regeneration negative regulation of cell projection organization peptidyl-tyrosine dephosphorylation chondroitin sulfate proteoglycan binding negative regulation of epidermal growth factor receptor signaling pathway phosphate ion binding neuron projection neuronal cell body positive regulation of apoptotic process intracellular membrane-bounded organelle positive regulation of neuron apoptotic process macromolecular complex binding negative regulation of insulin receptor signaling pathway regulation of axon regeneration positive regulation of dendrite morphogenesis regulation of synapse structure or activity cell adhesion molecule binding negative regulation of neurotrophin TRK receptor signaling pathway excitatory synapse integral component of postsynaptic density membrane synaptic membrane adhesion negative regulation of receptor binding uc008ujq.1 uc008ujq.2 uc008ujq.3 
ENSMUST00000049079.9 Prss1l ENSMUST00000049079.9 serine protease 1 (trypsin 1) like (from RefSeq NM_001038997.2) EG436523 ENSMUST00000049079.1 ENSMUST00000049079.2 ENSMUST00000049079.3 ENSMUST00000049079.4 ENSMUST00000049079.5 ENSMUST00000049079.6 ENSMUST00000049079.7 ENSMUST00000049079.8 Gm5771 NM_001038997 Prss1l Q792Y9 Q792Y9_MOUSE trypsinogen uc009bow.1 uc009bow.2 uc009bow.3 uc009bow.4 serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009bow.1 uc009bow.2 uc009bow.3 uc009bow.4 
ENSMUST00000049089.7 Twist1 ENSMUST00000049089.7 twist basic helix-loop-helix transcription factor 1 (from RefSeq NM_011658.2) ENSMUST00000049089.1 ENSMUST00000049089.2 ENSMUST00000049089.3 ENSMUST00000049089.4 ENSMUST00000049089.5 ENSMUST00000049089.6 NM_011658 P26687 TWST1_MOUSE Twist uc007niw.1 uc007niw.2 uc007niw.3 Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. This gene encodes a bHLH transcription factor that is evolutionarily conserved from invertebrates to humans, and was originally identified in Drosophila as an essential gene involved in early mesoderm development and dorsal-ventral patterning in the embryo. This protein plays a role in cancer by regulating the epithelial-mesenchymal transition (EMT), a process that is critical for metastasis initiation, and promoting tumor progression. Mutations in the human gene are associated with Saethre-Chotzen syndrome (SCS). Mice with heterozygous mutations in this gene exhibit cranofacial and structural defects similar to those seen in human SCS patients. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC083139.1, M63650.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer. Efficient DNA binding requires dimerization with another bHLH protein (PubMed:16502419, PubMed:17893140). Homodimer or heterodimer with E proteins such as TCF3 (PubMed:16502419, PubMed:17893140, PubMed:23395635). ID1 binds preferentially to TCF3 but does not interact efficiently with TWIST1 so ID1 levels control the amount of TCF3 available to dimerize with TWIST1 and thus determine the type of dimer formed (PubMed:16502419, PubMed:17893140). P26687; Q9UN86: G3BP2; Xeno; NbExp=2; IntAct=EBI-6123119, EBI-1044298; P26687; P04637: TP53; Xeno; NbExp=4; IntAct=EBI-6123119, EBI-366083; Nucleus. Subset of mesodermal cells. By TNF-alpha. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ossification osteoblast differentiation in utero embryonic development neuron migration neural tube closure aortic valve morphogenesis mitral valve morphogenesis endocardial cushion morphogenesis cardiac neural crest cell migration involved in outflow tract morphogenesis DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm multicellular organism development muscle organ development transcription factor binding positive regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of phosphatidylinositol 3-kinase signaling protein domain specific binding cell differentiation embryonic limb morphogenesis regulation of bone mineralization positive regulation of fatty acid beta-oxidation negative regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production negative regulation of histone phosphorylation negative regulation of histone acetylation embryonic forelimb morphogenesis embryonic hindlimb morphogenesis hindlimb morphogenesis negative regulation of peroxisome proliferator activated receptor signaling pathway odontogenesis embryonic digit morphogenesis protein homodimerization activity negative regulation of apoptotic process bHLH transcription factor binding negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of molecular function negative regulation of cell differentiation negative regulation of osteoblast differentiation negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity rhythmic process negative regulation of skeletal muscle tissue development embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis positive regulation of epithelial cell proliferation palate development bone development cranial suture morphogenesis embryonic camera-type eye formation eyelid development in camera-type eye cardiac neural crest cell development involved in outflow tract morphogenesis E-box binding cellular response to growth factor stimulus cellular response to hypoxia positive regulation of monocyte chemotactic protein-1 production positive regulation of DNA-templated transcription, initiation positive regulation of cell motility negative regulation of oxidative phosphorylation uncoupler activity positive regulation of transcription regulatory region DNA binding negative regulation of cellular senescence positive regulation of interleukin-6 secretion negative regulation of double-strand break repair cell proliferation involved in heart valve development positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation uc007niw.1 uc007niw.2 uc007niw.3 
ENSMUST00000049091.9 Cox10 ENSMUST00000049091.9 heme A:farnesyltransferase cytochrome c oxidase assembly factor 10 (from RefSeq NM_178379.3) COX10_MOUSE ENSMUST00000049091.1 ENSMUST00000049091.2 ENSMUST00000049091.3 ENSMUST00000049091.4 ENSMUST00000049091.5 ENSMUST00000049091.6 ENSMUST00000049091.7 ENSMUST00000049091.8 NM_178379 Q8CFY5 uc007jko.1 uc007jko.2 uc007jko.3 uc007jko.4 Converts protoheme IX and farnesyl diphosphate to heme O. Reaction=(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o; Xref=Rhea:RHEA:28070, ChEBI:CHEBI:15377, ChEBI:CHEBI:33019, ChEBI:CHEBI:60344, ChEBI:CHEBI:60530, ChEBI:CHEBI:175763; EC=2.5.1.141; Evidence=; Mitochondrion membrane ; Multi-pass membrane protein Belongs to the UbiA prenyltransferase family. mitochondrial fission cytochrome-c oxidase activity farnesyltranstransferase activity nucleolus mitochondrion cytosol heme biosynthetic process heme a biosynthetic process mitochondrion organization protoheme IX farnesyltransferase activity respiratory chain complex IV assembly aerobic respiration membrane integral component of membrane transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups cytochrome complex assembly protein farnesylation electron transport chain mitochondrial membrane cellular respiration heme O biosynthetic process cytochrome complex hydrogen ion transmembrane transport uc007jko.1 uc007jko.2 uc007jko.3 uc007jko.4 
ENSMUST00000049095.6 Faah ENSMUST00000049095.6 fatty acid amide hydrolase, transcript variant 3 (from RefSeq NR_185205.1) ENSMUST00000049095.1 ENSMUST00000049095.2 ENSMUST00000049095.3 ENSMUST00000049095.4 ENSMUST00000049095.5 FAAH1_MOUSE Faah1 NR_185205 O08914 Q922S0 Q9DBF5 uc008ufs.1 uc008ufs.2 uc008ufs.3 uc008ufs.4 Catalyzes the hydrolysis of endogenous amidated lipids like the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)- ethanolamine), as well as other fatty amides such as the taurine- conjugated fatty acids (a structural class of central nervous system (CNS) metabolites), to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:15533037, PubMed:32271712). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N- fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (PubMed:32271712). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-glycerol) (By similarity). Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine; Xref=Rhea:RHEA:26136, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:57603; EC=3.5.1.99; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26137; Evidence=; Reaction=(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+); Xref=Rhea:RHEA:26506, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:30823, ChEBI:CHEBI:116314; EC=3.5.1.99; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26507; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26133; Evidence=; Reaction=H2O + N-(9Z-hexadecenoyl) ethanolamine = (9Z)-hexadecenoate + ethanolamine; Xref=Rhea:RHEA:35563, ChEBI:CHEBI:15377, ChEBI:CHEBI:32372, ChEBI:CHEBI:57603, ChEBI:CHEBI:71465; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35564; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl) ethanolamine = (9Z)-octadecenoate + ethanolamine; Xref=Rhea:RHEA:45060, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57603, ChEBI:CHEBI:71466; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45061; Evidence=; Reaction=H2O + N-octadecanoyl ethanolamine = ethanolamine + octadecanoate; Xref=Rhea:RHEA:63124, ChEBI:CHEBI:15377, ChEBI:CHEBI:25629, ChEBI:CHEBI:57603, ChEBI:CHEBI:85299; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63125; Evidence=; Reaction=H2O + N-docosanoyl-ethanolamine = docosanoate + ethanolamine; Xref=Rhea:RHEA:63128, ChEBI:CHEBI:15377, ChEBI:CHEBI:23858, ChEBI:CHEBI:57603, ChEBI:CHEBI:146186; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63129; Evidence=; Reaction=H2O + N-tetracosanoyl-taurine = taurine + tetracosanoate; Xref=Rhea:RHEA:63140, ChEBI:CHEBI:15377, ChEBI:CHEBI:31014, ChEBI:CHEBI:132049, ChEBI:CHEBI:507393; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63141; Evidence=; Reaction=H2O + N-(15Z-tetracosenoyl)-ethanolamine = (15Z)- tetracosenoate + ethanolamine; Xref=Rhea:RHEA:63144, ChEBI:CHEBI:15377, ChEBI:CHEBI:32392, ChEBI:CHEBI:57603, ChEBI:CHEBI:146187; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63145; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-taurine = (9Z)-octadecenoate + taurine; Xref=Rhea:RHEA:63148, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:146191, ChEBI:CHEBI:507393; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63149; Evidence=; Reaction=H2O + N-docosanoyl-taurine = docosanoate + taurine; Xref=Rhea:RHEA:63156, ChEBI:CHEBI:15377, ChEBI:CHEBI:23858, ChEBI:CHEBI:146196, ChEBI:CHEBI:507393; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63157; Evidence=; Reaction=H2O + N-(15Z-tetracosenoyl)-taurine = (15Z)-tetracosenoate + taurine; Xref=Rhea:RHEA:63160, ChEBI:CHEBI:15377, ChEBI:CHEBI:32392, ChEBI:CHEBI:146198, ChEBI:CHEBI:507393; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63161; Evidence=; Reaction=H2O + N-tricosanoyl-taurine = taurine + tricosanoate; Xref=Rhea:RHEA:63164, ChEBI:CHEBI:15377, ChEBI:CHEBI:79007, ChEBI:CHEBI:146197, ChEBI:CHEBI:507393; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63165; Evidence=; Reaction=(9Z,12Z,15Z)-octadecatrienamide + H2O = (9Z,12Z,15Z)- octadecatrienoate + NH4(+); Xref=Rhea:RHEA:62976, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:32387, ChEBI:CHEBI:142684; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62977; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O = (5Z,8Z,11Z,14Z)- eicosatetraenoate + NH4(+); Xref=Rhea:RHEA:63016, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:32395, ChEBI:CHEBI:137830; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63017; Evidence=; Reaction=(6Z)-octadecenamide + H2O = (6Z)-octadecenoate + NH4(+); Xref=Rhea:RHEA:63008, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:32375, ChEBI:CHEBI:146168; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63009; Evidence=; Reaction=(15Z)-tetracosenamide + H2O = (15Z)-tetracosenoate + NH4(+); Xref=Rhea:RHEA:63028, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:32392, ChEBI:CHEBI:146166; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63029; Evidence=; Reaction=(8Z,11Z,14Z)-eicosatrienamide + H2O = (8Z,11Z,14Z)- eicosatrienoate + NH4(+); Xref=Rhea:RHEA:62996, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:71589, ChEBI:CHEBI:146163; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62997; Evidence=; Reaction=(11Z,14Z,17Z)-eicosatrienamide + H2O = (11Z,14Z,17Z)- eicosatrienoate + NH4(+); Xref=Rhea:RHEA:63000, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:77223, ChEBI:CHEBI:146164; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63001; Evidence=; Reaction=(11Z,14Z)-eicosadienamide + H2O = (11Z,14Z)-eicosadienoate + NH4(+); Xref=Rhea:RHEA:63004, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:77220, ChEBI:CHEBI:146165; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63005; Evidence=; Reaction=(9Z,12Z)-octadecadienamide + H2O = (9Z,12Z)-octadecadienoate + NH4(+); Xref=Rhea:RHEA:63020, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:30245, ChEBI:CHEBI:82984; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63021; Evidence=; Reaction=H2O + tetradecamide = NH4(+) + tetradecanoate; Xref=Rhea:RHEA:62992, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:30807, ChEBI:CHEBI:137125; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62993; Evidence=; Reaction=1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol; Xref=Rhea:RHEA:63052, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:32395, ChEBI:CHEBI:78033; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63053; Evidence=; Reaction=(11Z)-eicosenamide + H2O = (11Z)-eicosenoate + NH4(+); Xref=Rhea:RHEA:63120, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:32426, ChEBI:CHEBI:146167; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63121; Evidence=; Reaction=(9Z)-octadecenoate + glycine = H2O + N-(9Z- octadecenoyl)glycine; Xref=Rhea:RHEA:51316, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57305, ChEBI:CHEBI:133992; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:51318; Evidence=; Reaction=H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine; Xref=Rhea:RHEA:64108, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:57305, ChEBI:CHEBI:59002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64109; Evidence=; Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine; Xref=Rhea:RHEA:64116, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:33384, ChEBI:CHEBI:149697; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64117; Evidence=; Inhibited the trifluoromethyl compound PF-3845. Homodimer. Endoplasmic reticulum membrane ; Single-pass membrane protein Golgi apparatus membrane ; Single-pass membrane protein Note=Seems to be associated with the endoplasmic reticulum and/or Golgi apparatus. Genetic ablation of FAAH bidirectionally dysregulates a subset of intracellular, but not circulating, N-fatty acyl amino acids. Belongs to the amidase family. Golgi membrane amidase activity phospholipid binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus lipid binding fatty acid catabolic process membrane integral component of membrane hydrolase activity hydrolase activity, acting on ester bonds fatty acid amide hydrolase activity organelle membrane identical protein binding protein homodimerization activity acylglycerol lipase activity monoacylglycerol catabolic process oleamide hydrolase activity anandamide amidohydrolase activity uc008ufs.1 uc008ufs.2 uc008ufs.3 uc008ufs.4 
ENSMUST00000049124.10 C1rl ENSMUST00000049124.10 complement component 1, r subcomponent-like (from RefSeq NM_181344.5) C1RL_MOUSE C1rlp ENSMUST00000049124.1 ENSMUST00000049124.2 ENSMUST00000049124.3 ENSMUST00000049124.4 ENSMUST00000049124.5 ENSMUST00000049124.6 ENSMUST00000049124.7 ENSMUST00000049124.8 ENSMUST00000049124.9 NM_181344 Q3UZ09 Q3V019 Q7TT43 Q7TT44 uc009dqy.1 uc009dqy.2 uc009dqy.3 Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum. Secreted. Expressed in liver (at protein level). Belongs to the peptidase S1 family. immune system process serine-type endopeptidase activity extracellular region extracellular space proteolysis complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity zymogen activation innate immune response uc009dqy.1 uc009dqy.2 uc009dqy.3 
ENSMUST00000049126.13 Dner ENSMUST00000049126.13 delta/notch-like EGF repeat containing (from RefSeq NM_152915.1) Bet Bret DNER_MOUSE ENSMUST00000049126.1 ENSMUST00000049126.10 ENSMUST00000049126.11 ENSMUST00000049126.12 ENSMUST00000049126.2 ENSMUST00000049126.3 ENSMUST00000049126.4 ENSMUST00000049126.5 ENSMUST00000049126.6 ENSMUST00000049126.7 ENSMUST00000049126.8 ENSMUST00000049126.9 NM_152915 Q3U697 Q8JZM4 Q8R226 Q8R4T6 Q8VD97 uc007bsw.1 uc007bsw.2 Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling. Interacts with AP1G1. Interacts with NOTCH1. Cell membrane ingle-pass type I membrane protein Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region. Specifically expressed in brain neurons (at protein level). Expression in the central nervous system starts at 11 dpc, peaks during postnatal development and declines in the adult brain. At P7 and P20, present in several types of post-mitotic neurons, including cortical and hippocampal pyramidal neurons, cerebellar granule cells and Purkinje cells. Absent from mitotic neuroblasts in the ventricular zones. N-glycosylated. Mice show no obvious abnormality and no apparent survival disadvantage. However, they have delayed cerebellar histogenesis and exhibit motor discoordination at adult stages. Sequence=BAE31470.1; Type=Frameshift; Evidence=; Sequence=BAE31828.1; Type=Frameshift; Evidence=; Notch binding calcium ion binding early endosome plasma membrane Notch signaling pathway Notch receptor processing multicellular organism development central nervous system development glial cell differentiation membrane integral component of membrane cell differentiation dendrite neuronal cell body skeletal muscle fiber development uc007bsw.1 uc007bsw.2 
ENSMUST00000049130.8 Bex2 ENSMUST00000049130.8 brain expressed X-linked 2 (from RefSeq NM_009749.2) BEX2_MOUSE Bex2 ENSMUST00000049130.1 ENSMUST00000049130.2 ENSMUST00000049130.3 ENSMUST00000049130.4 ENSMUST00000049130.5 ENSMUST00000049130.6 ENSMUST00000049130.7 NM_009749 Q9WTZ8 uc009uia.1 uc009uia.2 uc009uia.3 uc009uia.4 Regulator of mitochondrial apoptosis and G1 cell cycle (By similarity). Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (PubMed:34562363). Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2 (By similarity). Interacts with OMP (PubMed:12911636, PubMed:15198671). Cytoplasm Nucleus Primarily localized to neuronal cells within several regions of the brain, including the olfactory epithelium, bulb, peri/paraventricular nuclei, suprachiasmatic nucleus, arcuate nucleus, median eminence, lateral hypothalamic area, thalamus, hippocampus and cerebellum (at protein level). The histidine cluster (His cluster) and Cys-126 mediate zinc- binding. Belongs to the BEX family. RNA polymerase II activating transcription factor binding protein binding nucleus transcription factor complex cytoplasm apoptotic process cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity uc009uia.1 uc009uia.2 uc009uia.3 uc009uia.4 
ENSMUST00000049138.8 Spring1 ENSMUST00000049138.8 SREBF pathway regulator in golgi 1 (from RefSeq NM_001081236.1) ENSMUST00000049138.1 ENSMUST00000049138.2 ENSMUST00000049138.3 ENSMUST00000049138.4 ENSMUST00000049138.5 ENSMUST00000049138.6 ENSMUST00000049138.7 NM_001081236 Q8BTG6 SPRNG_MOUSE Spring uc008zgj.1 uc008zgj.2 uc008zgj.3 Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP (PubMed:32111832). Plays a crucial role during embyrogenesis (PubMed:32111832). Interacts with SCAP. Golgi apparatus membrane ; Single-pass membrane protein Ubiquitously expressed with a slightly higher expression in the liver and kidney. Knockout leads to early embryonic lethality. Belongs to the SPRING family. molecular_function cellular_component extracellular region biological_process uc008zgj.1 uc008zgj.2 uc008zgj.3 
ENSMUST00000049146.12 Ephx4 ENSMUST00000049146.12 epoxide hydrolase 4, transcript variant 3 (from RefSeq NM_001379225.1) Abhd7 ENSMUST00000049146.1 ENSMUST00000049146.10 ENSMUST00000049146.11 ENSMUST00000049146.2 ENSMUST00000049146.3 ENSMUST00000049146.4 ENSMUST00000049146.5 ENSMUST00000049146.6 ENSMUST00000049146.7 ENSMUST00000049146.8 ENSMUST00000049146.9 EPHX4_MOUSE Ephxrp F8VQ47 NM_001379225 Q6IE26 uc008yme.1 uc008yme.2 uc008yme.3 uc008yme.4 Membrane ; Single-pass type II membrane protein Belongs to the AB hydrolase superfamily. Epoxide hydrolase family. catalytic activity cellular_component membrane integral component of membrane hydrolase activity uc008yme.1 uc008yme.2 uc008yme.3 uc008yme.4 
ENSMUST00000049149.15 Lrp1 ENSMUST00000049149.15 low density lipoprotein receptor-related protein 1 (from RefSeq NM_008512.2) A0A0R4J0I9 A0A0R4J0I9_MOUSE ENSMUST00000049149.1 ENSMUST00000049149.10 ENSMUST00000049149.11 ENSMUST00000049149.12 ENSMUST00000049149.13 ENSMUST00000049149.14 ENSMUST00000049149.2 ENSMUST00000049149.3 ENSMUST00000049149.4 ENSMUST00000049149.5 ENSMUST00000049149.6 ENSMUST00000049149.7 ENSMUST00000049149.8 ENSMUST00000049149.9 Lrp1 NM_008512 uc007hjx.1 uc007hjx.2 uc007hjx.3 uc007hjx.4 Membrane ; Single- pass type I membrane protein Belongs to the LDLR family. Lacks conserved residue(s) required for the propagation of feature annotation. protease binding calcium ion binding endosome early endosome receptor-mediated endocytosis phagocytosis positive regulation of cytosolic calcium ion concentration protein kinase C-activating G-protein coupled receptor signaling pathway aging cell proliferation negative regulation of cell-substrate adhesion positive regulation of cell death positive regulation of neuron projection development negative regulation of neuron projection development coreceptor activity membrane integral component of membrane basolateral plasma membrane alpha-2 macroglobulin receptor activity cerebral cortex development clathrin-coated vesicle dendrite clathrin heavy chain binding positive regulation of protein binding insulin-responsive compartment apolipoprotein binding positive regulation of insulin secretion involved in cellular response to glucose stimulus cargo receptor activity lipoprotein metabolic process neuronal cell body negative regulation of apoptotic process receptor complex negative regulation of neuron apoptotic process cellular lipid catabolic process axonal growth cone macromolecular complex binding apical part of cell positive regulation of axon extension positive regulation of endocytosis positive regulation of axon extension involved in regeneration positive regulation of collateral sprouting of injured axon positive regulation of phagocytosis positive regulation of protein transport negative regulation of cytosolic calcium ion concentration negative regulation of focal adhesion assembly negative regulation of cell death chemoattraction of axon positive regulation of ERK1 and ERK2 cascade positive regulation of Schwann cell migration positive regulation of protein localization to plasma membrane positive regulation of cholesterol import positive regulation of chemokine (C-C motif) ligand 2 secretion positive regulation of vascular associated smooth muscle cell migration positive regulation of lysosomal protein catabolic process uc007hjx.1 uc007hjx.2 uc007hjx.3 uc007hjx.4 
ENSMUST00000049150.8 Styk1 ENSMUST00000049150.8 serine/threonine/tyrosine kinase 1, transcript variant 1 (from RefSeq NM_172891.3) ENSMUST00000049150.1 ENSMUST00000049150.2 ENSMUST00000049150.3 ENSMUST00000049150.4 ENSMUST00000049150.5 ENSMUST00000049150.6 ENSMUST00000049150.7 NM_172891 Nok Q6J9G1 Q8BZH6 Q8BZT1 STYK1_MOUSE uc009eir.1 uc009eir.2 uc009eir.3 Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines including NIH 3T3 fibroblasts and on athymic nude mice. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6J9G1-1; Sequence=Displayed; Name=2; IsoId=Q6J9G1-2; Sequence=VSP_013427; Highly expressed in colon and small intestine. Weakly or not expressed in spleen, skeletal muscle, liver, kidney, heart and brain. Expressed in transformed kidney cell lines (COS-1 and HEK293T). Belongs to the protein kinase superfamily. Tyr protein kinase family. nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity ATP binding plasma membrane protein phosphorylation membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation uc009eir.1 uc009eir.2 uc009eir.3 
ENSMUST00000049151.4 Pus7l ENSMUST00000049151.4 pseudouridylate synthase 7-like (from RefSeq NM_172437.3) ENSMUST00000049151.1 ENSMUST00000049151.2 ENSMUST00000049151.3 NM_172437 PUS7L_MOUSE Pus7l Q6NY03 Q8C9X5 Q8CE46 uc007xjh.1 uc007xjh.2 uc007xjh.3 uc007xjh.4 Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. Reaction=a uridine in mRNA = a pseudouridine in mRNA; Xref=Rhea:RHEA:56644, Rhea:RHEA-COMP:14658, Rhea:RHEA-COMP:14659, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Belongs to the pseudouridine synthase TruD family. Sequence=BAC30554.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. May result from internal priming due to genomic poly-A tracts.; Evidence=; pseudouridine synthesis RNA binding nucleus RNA modification pseudouridine synthase activity isomerase activity uc007xjh.1 uc007xjh.2 uc007xjh.3 uc007xjh.4 
ENSMUST00000049152.15 Snx10 ENSMUST00000049152.15 sorting nexin 10, transcript variant 10 (from RefSeq NM_001361582.1) ENSMUST00000049152.1 ENSMUST00000049152.10 ENSMUST00000049152.11 ENSMUST00000049152.12 ENSMUST00000049152.13 ENSMUST00000049152.14 ENSMUST00000049152.2 ENSMUST00000049152.3 ENSMUST00000049152.4 ENSMUST00000049152.5 ENSMUST00000049152.6 ENSMUST00000049152.7 ENSMUST00000049152.8 ENSMUST00000049152.9 NM_001361582 Q8C1E0 Q9CWT3 SNX10_MOUSE uc009bxs.1 uc009bxs.2 uc009bxs.3 uc009bxs.4 Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption. Interacts with ATP6V1D; may play a role in ciliogenesis. Cytoplasm Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=May also localize to nucleus and endoplasmic reticulum. Expressed in femur, calvariae and teeth. Strongly up-regulated during osteoclastogenesis. Expressed in calvariae and developing teeth as early as 16.5 dpc (at protein level). The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate. Belongs to the sorting nexin family. gastric acid secretion 1-phosphatidylinositol binding nucleus cytoplasm endosome endoplasmic reticulum centrosome microtubule organizing center cytoskeleton endocytosis endosome organization lipid binding endosome membrane protein transport membrane cell projection organization secretory granule bone mineralization osteoclast differentiation extrinsic component of endosome membrane phosphatidylinositol binding tooth eruption bone resorption ATPase binding calcium ion homeostasis cilium assembly protein localization to cilium protein localization to centrosome apical cytoplasm ruffle assembly cellular response to leukemia inhibitory factor uc009bxs.1 uc009bxs.2 uc009bxs.3 uc009bxs.4 
ENSMUST00000049156.7 Meak7 ENSMUST00000049156.7 MTOR associated protein, eak-7 homolog (from RefSeq NM_028883.2) ENSMUST00000049156.1 ENSMUST00000049156.2 ENSMUST00000049156.3 ENSMUST00000049156.4 ENSMUST00000049156.5 ENSMUST00000049156.6 Kiaa1609 MEAK7_MOUSE NM_028883 Q69ZF1 Q8K0P3 Tldc1 uc009nqh.1 uc009nqh.2 uc009nqh.3 Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration. Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome. Interacts (via C-terminal domain) with MTOR and MLST8; the interaction with MTOR increases upon nutrient stimulation. Membrane Cytoplasm Lysosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K0P3-1; Sequence=Displayed; Name=2; IsoId=Q8K0P3-2; Sequence=VSP_030079, VSP_030080; Sequence=BAD32493.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAD32493.1; Type=Frameshift; Evidence=; molecular_function cytoplasm lysosome lysosomal membrane membrane regulation of cell migration response to nutrient levels TOR signaling response to insulin regulation of cell proliferation response to amino acid negative regulation of oxidative stress-induced neuron death uc009nqh.1 uc009nqh.2 uc009nqh.3 
ENSMUST00000049166.5 Bet1 ENSMUST00000049166.5 Bet1 golgi vesicular membrane trafficking protein (from RefSeq NM_009748.3) BET1_MOUSE ENSMUST00000049166.1 ENSMUST00000049166.2 ENSMUST00000049166.3 ENSMUST00000049166.4 NM_009748 O35623 uc009avk.1 uc009avk.2 uc009avk.3 Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER- derived vesicles with the cis-Golgi membrane (By similarity). Interacts with STX17. Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Golgi apparatus, cis-Golgi network membrane Golgi apparatus membrane Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). Belongs to the BET1 family. Golgi cis cisterna Golgi trans cisterna Golgi membrane SNAP receptor activity endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cis-Golgi network ER to Golgi vesicle-mediated transport protein transport membrane integral component of membrane vesicle-mediated transport syntaxin binding integral component of Golgi membrane SNARE complex Golgi cisterna vesicle fusion with Golgi apparatus uc009avk.1 uc009avk.2 uc009avk.3 
ENSMUST00000049167.14 Phf12 ENSMUST00000049167.14 PHD finger protein 12 (from RefSeq NM_174852.3) ENSMUST00000049167.1 ENSMUST00000049167.10 ENSMUST00000049167.11 ENSMUST00000049167.12 ENSMUST00000049167.13 ENSMUST00000049167.2 ENSMUST00000049167.3 ENSMUST00000049167.4 ENSMUST00000049167.5 ENSMUST00000049167.6 ENSMUST00000049167.7 ENSMUST00000049167.8 ENSMUST00000049167.9 Kiaa1523 NM_174852 PHF12_MOUSE Phf12 Q5SPL2 Q5SPL3 Q6ZPN8 Q80W50 uc007kht.1 uc007kht.2 uc007kht.3 uc007kht.4 uc007kht.5 Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (By similarity). Interacts with SIN3A in a complex composed of HDAC1, SAP30 and SIN3A. Interacts with TLE5 (By similarity). Q5SPL2; Q9UBU8-2: MORF4L1; Xeno; NbExp=2; IntAct=EBI-15963335, EBI-10288852; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SPL2-1; Sequence=Displayed; Name=2; IsoId=Q5SPL2-2; Sequence=VSP_051773, VSP_051774; Expressed mainly in heart, brain, lung, liver and testis. Expression is low in day 7 embryos, peaks at day 11 and declines through to day 17. Sequence=AAH43080.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter transcription corepressor binding transcription corepressor activity protein binding nucleus nucleoplasm Sin3 complex transcriptional repressor complex phosphatidylinositol binding negative regulation of transcription, DNA-templated metal ion binding Sin3-type complex uc007kht.1 uc007kht.2 uc007kht.3 uc007kht.4 uc007kht.5 
ENSMUST00000049168.9 Cog3 ENSMUST00000049168.9 component of oligomeric golgi complex 3, transcript variant 1 (from RefSeq NM_177381.4) Cog3 E9QL65 E9QL65_MOUSE ENSMUST00000049168.1 ENSMUST00000049168.2 ENSMUST00000049168.3 ENSMUST00000049168.4 ENSMUST00000049168.5 ENSMUST00000049168.6 ENSMUST00000049168.7 ENSMUST00000049168.8 NM_177381 uc007uqw.1 uc007uqw.2 uc007uqw.3 Involved in ER-Golgi transport. Belongs to the COG3 family. Golgi apparatus cis-Golgi network cytosol plasma membrane protein glycosylation intracellular protein transport ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER intra-Golgi vesicle-mediated transport Golgi organization membrane Golgi transport complex protein localization to organelle protein stabilization uc007uqw.1 uc007uqw.2 uc007uqw.3 
ENSMUST00000049178.3 Cyp2c37 ENSMUST00000049178.3 cytochrome P450, family 2. subfamily c, polypeptide 37 (from RefSeq NM_010001.2) CP237_MOUSE Cyp2c37 E9QKN4 ENSMUST00000049178.1 ENSMUST00000049178.2 NM_010001 P56654 uc008hkf.1 uc008hkf.2 uc008hkf.3 A cytochrome P450 monooxygenase that metabolizes (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to primarily produce 12-hydroxyeicosatetraenoic acid (12-HETE). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase). Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51484, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:90718; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51485; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Lipid metabolism; arachidonate metabolism. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Liver. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding organelle membrane exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc008hkf.1 uc008hkf.2 uc008hkf.3 
ENSMUST00000049184.9 Ushbp1 ENSMUST00000049184.9 USH1 protein network component harmonin binding protein 1 (from RefSeq NM_181418.3) E9QKT2 ENSMUST00000049184.1 ENSMUST00000049184.2 ENSMUST00000049184.3 ENSMUST00000049184.4 ENSMUST00000049184.5 ENSMUST00000049184.6 ENSMUST00000049184.7 ENSMUST00000049184.8 NM_181418 Q8R370 USBP1_MOUSE Ushbp1 uc009mcz.1 uc009mcz.2 uc009mcz.3 uc009mcz.4 Interacts via its C-terminus with the first PDZ domain of USH1C. Belongs to the MCC family. cellular_component biological_process PDZ domain binding uc009mcz.1 uc009mcz.2 uc009mcz.3 uc009mcz.4 
ENSMUST00000049185.6 Ybey ENSMUST00000049185.6 ybeY metallopeptidase (from RefSeq NM_172550.4) ENSMUST00000049185.1 ENSMUST00000049185.2 ENSMUST00000049185.3 ENSMUST00000049185.4 ENSMUST00000049185.5 NM_172550 Q3UW80 Q6PG17 Q8CAV0 YBEY_MOUSE uc007fuo.1 uc007fuo.2 Single strand-specific metallo-endoribonuclease involved in rRNA maturation. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion. ; Belongs to the endoribonuclease YbeY family. metalloendopeptidase activity nuclease activity endonuclease activity endoribonuclease activity nucleus mitochondrion rRNA processing proteolysis biological_process hydrolase activity metal ion binding nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc007fuo.1 uc007fuo.2 
ENSMUST00000049208.11 Hjv ENSMUST00000049208.11 hemojuvelin BMP co-receptor (from RefSeq NM_027126.4) ENSMUST00000049208.1 ENSMUST00000049208.10 ENSMUST00000049208.2 ENSMUST00000049208.3 ENSMUST00000049208.4 ENSMUST00000049208.5 ENSMUST00000049208.6 ENSMUST00000049208.7 ENSMUST00000049208.8 ENSMUST00000049208.9 Hfe2 Hjv NM_027126 Q7TQ32 Q8CEU7 Q8K1D4 Q9D741 RGMC_MOUSE Rgmc uc008qna.1 uc008qna.2 uc008qna.3 uc008qna.4 Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. Interacts with BMP2 and BMP4 (PubMed:16604073). Interacts with BMP6 (PubMed:19252486). Interacts with BMPR1B (By similarity). Interacts with TMPRSS6 (By similarity). Cell membrane ; Lipid-anchor, GPI- anchor Note=Also released in the extracellular space. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TQ32-1; Sequence=Displayed; Name=2; IsoId=Q7TQ32-2; Sequence=VSP_011321; Muscle cell lineage. Expressed at low levels in somite derived structures. In the developing eye, marked the ocular musculature. Expressed in all differentiating muscles of the limb and the body wall, but not in migrating muscle precursor cells. Not detected in the nervous system, either at 9.5 dpc or at any stage later during development. Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space; regulates HJV activity in BMP signaling and thefore iron homeostasis. Belongs to the repulsive guidance molecule (RGM) family. negative regulation of transcription from RNA polymerase II promoter receptor binding extracellular space plasma membrane cellular iron ion homeostasis cell surface coreceptor activity membrane basolateral plasma membrane protein autoprocessing BMP signaling pathway negative regulation of BMP signaling pathway anchored component of membrane activin receptor signaling pathway BMP binding positive regulation of transcription from RNA polymerase II promoter iron ion homeostasis BMP receptor complex cellular response to BMP stimulus plasma membrane protein complex BMP receptor activity transferrin receptor binding HFE-transferrin receptor complex uc008qna.1 uc008qna.2 uc008qna.3 uc008qna.4 
ENSMUST00000049209.13 Gc ENSMUST00000049209.13 vitamin D binding protein (from RefSeq NM_008096.2) ENSMUST00000049209.1 ENSMUST00000049209.10 ENSMUST00000049209.11 ENSMUST00000049209.12 ENSMUST00000049209.2 ENSMUST00000049209.3 ENSMUST00000049209.4 ENSMUST00000049209.5 ENSMUST00000049209.6 ENSMUST00000049209.7 ENSMUST00000049209.8 ENSMUST00000049209.9 NM_008096 P21614 Q7TS97 Q91XG1 Q9CY31 VTDB_MOUSE uc008yam.1 uc008yam.2 uc008yam.3 uc008yam.4 Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. Associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T- lymphocytes (By similarity). Interacts with LRP2; the interaction is required for renal uptake of GC in complex with 25-hydroxyvitamin D3 (PubMed:10052453). Secreted Belongs to the ALB/AFP/VDB family. actin binding vitamin D binding extracellular region extracellular space cytoplasm cytosol axon vitamin transmembrane transport vitamin D metabolic process perinuclear region of cytoplasm vitamin transport vitamin transmembrane transporter activity calcidiol binding uc008yam.1 uc008yam.2 uc008yam.3 uc008yam.4 
ENSMUST00000049230.11 Kcnab1 ENSMUST00000049230.11 potassium voltage-gated channel, shaker-related subfamily, beta member 1, transcript variant 1 (from RefSeq NM_010597.6) ENSMUST00000049230.1 ENSMUST00000049230.10 ENSMUST00000049230.2 ENSMUST00000049230.3 ENSMUST00000049230.4 ENSMUST00000049230.5 ENSMUST00000049230.6 ENSMUST00000049230.7 ENSMUST00000049230.8 ENSMUST00000049230.9 KCAB1_MOUSE Kvb1 NM_010597 P63143 P97380 Q61763 Q63277 Q91WM5 uc008pkj.1 uc008pkj.2 uc008pkj.3 uc008pkj.4 Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:10454353). Modulates action potentials via its effect on the pore-forming alpha subunits (PubMed:10454353). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (PubMed:8824288). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (By similarity). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (By similarity). Accelerates KCNA4 channel closure (By similarity). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (By similarity). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Enhances KCNB1 and KCNB2 channel activity (PubMed:8824288). Binds NADPH; this is required for efficient down- regulation of potassium channel activity (By similarity). Has NADPH- dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity). Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (Probable). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity). Interacts with KCNA1 (By similarity). Interacts with the dimer formed by GNB1 and GNG2; this enhances KCNA1 binding (By similarity). Interacts with KCNA4 (By similarity). Interacts with KCNB2 and KCNA5 (PubMed:8824288). Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1; interaction with LGI1 inhibits down-regulation of KCNA1 channel activity (By similarity). Cytoplasm Membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Detected in brain, in hippocampus and striatum (at protein level) (PubMed:10454353). Predominantly expressed in brain. No expression found in heart, skeletal muscle or kidney. In the late embryonic and early neonatal brain, highly expressed in hippocampus, cerebral cortex, caudate putamen, colliculus and cerebellum. Expressed from embryonic day 16. Expressed throughout embryonic development, in neonate and in adult. The N-terminal domain of the beta subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore. Mutant mice show subtle defects in learning (PubMed:10454353). Such learning impairments are not detectable in older mice and are not observed when mice are kept in a stimulating environment (PubMed:14511342, PubMed:15530391). Belongs to the shaker potassium channel beta subunit family. aldo-keto reductase (NADP) activity voltage-gated ion channel activity voltage-gated potassium channel activity protein binding cytoplasm cytosol plasma membrane ion transport potassium ion transport brain development heart development skeletal muscle tissue development learning or memory voltage-gated potassium channel complex potassium channel regulator activity membrane integral component of membrane oxidoreductase activity protein domain specific binding axon extrinsic component of cytoplasmic side of plasma membrane dendrite cytoplasm ion transmembrane transport potassium channel complex regulation of ion transmembrane transport neuronal cell body perikaryon juxtaparanode region of axon ion channel binding myoblast differentiation transmembrane transport oxidation-reduction process diaphragm development NADPH binding potassium ion transmembrane transport regulation of potassium ion transmembrane transporter activity regulation of potassium ion transmembrane transport regulation of delayed rectifier potassium channel activity negative regulation of delayed rectifier potassium channel activity negative regulation of voltage-gated potassium channel activity proximal dendrite uc008pkj.1 uc008pkj.2 uc008pkj.3 uc008pkj.4 
ENSMUST00000049241.9 Hoxb4 ENSMUST00000049241.9 homeobox B4 (from RefSeq NM_010459.7) ENSMUST00000049241.1 ENSMUST00000049241.2 ENSMUST00000049241.3 ENSMUST00000049241.4 ENSMUST00000049241.5 ENSMUST00000049241.6 ENSMUST00000049241.7 ENSMUST00000049241.8 HXB4_MOUSE Hox-2.6 Hoxb-4 NM_010459 P10284 Q3UZB4 Q4VBG0 uc007lbv.1 uc007lbv.2 uc007lbv.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus. Belongs to the Antp homeobox family. Deformed subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development morphogenesis of an epithelial sheet DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm centrosome regulation of transcription, DNA-templated multicellular organism development cell proliferation anterior/posterior pattern specification hemopoiesis activating transcription factor binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter somatic stem cell division spleen development bone marrow development embryonic skeletal system morphogenesis skeletal system morphogenesis definitive hemopoiesis hematopoietic stem cell differentiation positive regulation of stem cell differentiation uc007lbv.1 uc007lbv.2 uc007lbv.3 
ENSMUST00000049242.9 Lrrc20 ENSMUST00000049242.9 leucine rich repeat containing 20 (from RefSeq NM_153542.1) ENSMUST00000049242.1 ENSMUST00000049242.2 ENSMUST00000049242.3 ENSMUST00000049242.4 ENSMUST00000049242.5 ENSMUST00000049242.6 ENSMUST00000049242.7 ENSMUST00000049242.8 LRC20_MOUSE NM_153542 Q8CI70 uc007fgc.1 uc007fgc.2 uc007fgc.3 uc007fgc.4 molecular_function cellular_component biological_process uc007fgc.1 uc007fgc.2 uc007fgc.3 uc007fgc.4 
ENSMUST00000049244.10 Dnajc28 ENSMUST00000049244.10 DnaJ heat shock protein family (Hsp40) member C28, transcript variant 2 (from RefSeq NM_138664.2) DJC28_MOUSE ENSMUST00000049244.1 ENSMUST00000049244.2 ENSMUST00000049244.3 ENSMUST00000049244.4 ENSMUST00000049244.5 ENSMUST00000049244.6 ENSMUST00000049244.7 ENSMUST00000049244.8 ENSMUST00000049244.9 NM_138664 ORF28 Q8VCE1 Q99JX0 uc007zxt.1 uc007zxt.2 uc007zxt.3 May have a role in protein folding or as a chaperone. molecular_function retrograde vesicle-mediated transport, Golgi to ER Golgi organization Golgi transport complex Golgi vesicle prefusion complex stabilization uc007zxt.1 uc007zxt.2 uc007zxt.3 
ENSMUST00000049245.10 Rbmxl1 ENSMUST00000049245.10 RNA binding motif protein, X-linked like-1, transcript variant 1 (from RefSeq NM_009033.2) ENSMUST00000049245.1 ENSMUST00000049245.2 ENSMUST00000049245.3 ENSMUST00000049245.4 ENSMUST00000049245.5 ENSMUST00000049245.6 ENSMUST00000049245.7 ENSMUST00000049245.8 ENSMUST00000049245.9 NM_009033 O35479 Q91VM5 RMXL1_MOUSE Rbmxrt uc009mhz.1 uc009mhz.2 uc009mhz.3 RNA-binding protein which may be involved in pre-mRNA splicing. Nucleus regulation of alternative mRNA splicing, via spliceosome RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleic acid binding chromatin binding RNA binding mRNA binding protein binding nucleus spliceosomal complex nuclear euchromatin transcription from RNA polymerase II promoter mRNA splice site selection mRNA processing membrane protein ectodomain proteolysis RNA splicing supraspliceosomal complex positive regulation of transcription from RNA polymerase II promoter negative regulation of mRNA splicing, via spliceosome positive regulation of mRNA splicing, via spliceosome protein homooligomerization extracellular exosome catalytic step 2 spliceosome cellular response to interleukin-1 ribonucleoprotein complex uc009mhz.1 uc009mhz.2 uc009mhz.3 
ENSMUST00000049246.7 Setmar ENSMUST00000049246.7 SET domain without mariner transposase fusion, transcript variant 1 (from RefSeq NM_178391.4) E9QLD6 ENSMUST00000049246.1 ENSMUST00000049246.2 ENSMUST00000049246.3 ENSMUST00000049246.4 ENSMUST00000049246.5 ENSMUST00000049246.6 NM_178391 Q80UJ9 SETMR_MOUSE Setmar uc009dde.1 uc009dde.2 uc009dde.3 uc009dde.4 uc009dde.5 This gene encodes a histone-lysine N-methyltransferase that may be involved in the methylation of histone H3. In anthropoid primates this gene is a fusion gene of a SET histone-lysine N-methyltransferase and a mariner (MAR) family transposase. In all other species this gene contains only the SET domain. [provided by RefSeq, Jan 2013]. Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Reaction=L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60308, Rhea:RHEA-COMP:9785, Rhea:RHEA- COMP:9787, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61976; EC=2.1.1.357; Evidence=; Nucleus Chromosome In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster. Belongs to the class V-like SAM-binding methyltransferase superfamily. nucleus chromosome chromatin organization methyltransferase activity zinc ion binding histone H3-K36 methylation transferase activity histone-lysine N-methyltransferase activity methylation histone lysine methylation histone methyltransferase activity (H3-K4 specific) metal ion binding histone methyltransferase activity (H3-K36 specific) histone H3-K4 methylation uc009dde.1 uc009dde.2 uc009dde.3 uc009dde.4 uc009dde.5 
ENSMUST00000049248.7 Malt1 ENSMUST00000049248.7 MALT1 paracaspase, transcript variant 1 (from RefSeq NM_172833.4) ENSMUST00000049248.1 ENSMUST00000049248.2 ENSMUST00000049248.3 ENSMUST00000049248.4 ENSMUST00000049248.5 ENSMUST00000049248.6 MALT1_MOUSE Malt1 NM_172833 Q2TBA2 Q2TBA3 Q811E3 Q8BFT0 Q8C7N9 uc008fez.1 uc008fez.2 uc008fez.3 uc008fez.4 Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor- induced integrin adhesion (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation (By similarity). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (PubMed:25282160). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (By similarity). Homooligomer; forms oligomers which bind to TRAF6. Forms a complex with CARD14 and MALT1; resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex. Forms a complex with CARD11 and MALT1; resulting in the formation of a CBM (CARD11-BCL10-MALT1) complex (By similarity). Forms a complex with CARD9 and MALT1; resulting in the formation of a CBM (CARD9-BCL10-MALT1) complex (PubMed:22265677). Cytoplasm, perinuclear region Nucleus Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q2TBA3-1; Sequence=Displayed; Name=2 ; IsoId=Q2TBA3-2; Sequence=VSP_052279; Belongs to the peptidase C14B family. fibrillar center B-1 B cell differentiation protease binding response to molecule of bacterial origin positive regulation of T cell cytokine production cysteine-type endopeptidase activity ubiquitin-protein transferase activity protein binding nucleus nucleolus cytoplasm cytosol proteolysis apoptotic process I-kappaB kinase/NF-kappaB signaling activation of NF-kappaB-inducing kinase activity peptidase activity response to fungus protein ubiquitination hydrolase activity kinase activator activity lipopolysaccharide-mediated signaling pathway CBM complex positive regulation of interleukin-1 beta production positive regulation of interleukin-2 production macromolecular complex T cell proliferation B cell activation identical protein binding regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein self-association innate immune response perinuclear region of cytoplasm T cell receptor signaling pathway regulation of T cell receptor signaling pathway positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity nuclear export protein oligomerization positive regulation of T-helper 17 cell differentiation uc008fez.1 uc008fez.2 uc008fez.3 uc008fez.4 
ENSMUST00000049251.6 Cpa4 ENSMUST00000049251.6 carboxypeptidase A4 (from RefSeq NM_027926.3) CBPA4_MOUSE ENSMUST00000049251.1 ENSMUST00000049251.2 ENSMUST00000049251.3 ENSMUST00000049251.4 ENSMUST00000049251.5 NM_027926 Q6P8K8 Q8BMK6 Q9CTE6 uc009bfo.1 uc009bfo.2 uc009bfo.3 This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases that could be involved in the histone hyperacetylation pathway. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]. ##Evidence-Data-START## Transcript exon combination :: BC061206.1, AK030705.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849376 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Interacts with LXN. Secreted Belongs to the peptidase M14 family. carboxypeptidase activity metallocarboxypeptidase activity extracellular region extracellular space proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding uc009bfo.1 uc009bfo.2 uc009bfo.3 
ENSMUST00000049255.7 Armc3 ENSMUST00000049255.7 armadillo repeat containing 3, transcript variant 4 (from RefSeq NM_001271565.1) A2AU71 A2AU71_MOUSE Armc3 ENSMUST00000049255.1 ENSMUST00000049255.2 ENSMUST00000049255.3 ENSMUST00000049255.4 ENSMUST00000049255.5 ENSMUST00000049255.6 NM_001271565 uc008imc.1 uc008imc.2 uc008imc.3 uc008imc.4 uc008imc.5 uc008imc.1 uc008imc.2 uc008imc.3 uc008imc.4 uc008imc.5 
ENSMUST00000049257.8 Ddx52 ENSMUST00000049257.8 DExD box helicase 52 (from RefSeq NM_030096.2) DDX52_MOUSE ENSMUST00000049257.1 ENSMUST00000049257.2 ENSMUST00000049257.3 ENSMUST00000049257.4 ENSMUST00000049257.5 ENSMUST00000049257.6 ENSMUST00000049257.7 NM_030096 Q3UZY9 Q8BV29 Q8K301 Rok1 uc007kpz.1 uc007kpz.2 uc007kpz.3 uc007kpz.4 uc007kpz.5 Required for efficient ribosome biogenesis. May control cell cycle progression by regulating translation of mRNAs that contain a terminal oligo pyrimidine (TOP) motif in their 5' UTRs, such as GTPBP4. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Nucleus, nucleolus Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus nucleolus hydrolase activity maturation of SSU-rRNA uc007kpz.1 uc007kpz.2 uc007kpz.3 uc007kpz.4 uc007kpz.5 
ENSMUST00000049260.7 Garem1 ENSMUST00000049260.7 GRB2 associated regulator of MAPK1 subtype 1 (from RefSeq NM_001033445.3) ENSMUST00000049260.1 ENSMUST00000049260.2 ENSMUST00000049260.3 ENSMUST00000049260.4 ENSMUST00000049260.5 ENSMUST00000049260.6 Fam59a G5E8B7 GARE1_MOUSE Garem Gm944 Kiaa4238 NM_001033445 Q3TSA2 Q3UFT3 Q5DTF6 Q80V96 uc008efg.1 uc008efg.2 uc008efg.3 Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Interacts with EGFR. Interacts (via proline-rich domain and phosphorylated at Tyr-105 and Tyr-453) with GRB2 (via SH3 domains); the interaction occurs upon EGF stimulation. Interacts (phosphorylated at Tyr-453) with PTPN11; the interaction increases MAPK/ERK activity and does not affect the GRB2/SOS complex formation (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UFT3-1; Sequence=Displayed; Name=2; IsoId=Q3UFT3-2; Sequence=VSP_023049, VSP_023050; On EGF stimulation, phosphorylated on Tyr-105 and Tyr-453. Belongs to the GAREM family. Sequence=BAD90542.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cellular_component epidermal growth factor receptor signaling pathway positive regulation of cell proliferation positive regulation of cell division proline-rich region binding positive regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus uc008efg.1 uc008efg.2 uc008efg.3 
ENSMUST00000049263.9 Sltm ENSMUST00000049263.9 SAFB-like, transcription modulator, transcript variant 1 (from RefSeq NM_025690.4) ENSMUST00000049263.1 ENSMUST00000049263.2 ENSMUST00000049263.3 ENSMUST00000049263.4 ENSMUST00000049263.5 ENSMUST00000049263.6 ENSMUST00000049263.7 ENSMUST00000049263.8 Met NM_025690 Q3UYE5 Q8BP76 Q8BR40 Q8CH25 Q8VCF4 Q9CS57 SLTM_MOUSE uc009qol.1 uc009qol.2 uc009qol.3 When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. Nucleus Note=Detected in punctate structures. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CH25-1; Sequence=Displayed; Name=2; IsoId=Q8CH25-2; Sequence=VSP_028834; Sequence=AAH19992.1; Type=Erroneous initiation; Evidence=; Sequence=BAC32471.1; Type=Erroneous initiation; Evidence=; Sequence=BAE22267.1; Type=Erroneous initiation; Evidence=; nucleic acid binding RNA binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter apoptotic process nuclear body sequence-specific DNA binding regulation of mRNA processing uc009qol.1 uc009qol.2 uc009qol.3 
ENSMUST00000049271.13 Tedc1 ENSMUST00000049271.13 tubulin epsilon and delta complex 1 (from RefSeq NM_134041.3) E9Q930 ENSMUST00000049271.1 ENSMUST00000049271.10 ENSMUST00000049271.11 ENSMUST00000049271.12 ENSMUST00000049271.2 ENSMUST00000049271.3 ENSMUST00000049271.4 ENSMUST00000049271.5 ENSMUST00000049271.6 ENSMUST00000049271.7 ENSMUST00000049271.8 ENSMUST00000049271.9 NM_134041 Q3TK97 Q3UK37 TEDC1_MOUSE Tedc1 uc007pga.1 uc007pga.2 uc007pga.3 uc007pga.4 Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability (PubMed:29459677). May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F (By similarity). Interacts with TEDC2 (PubMed:29459677). Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1 (PubMed:29459677). Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole molecular_function protein binding cellular_component centriole biological_process positive regulation of smoothened signaling pathway uc007pga.1 uc007pga.2 uc007pga.3 uc007pga.4 
ENSMUST00000049272.5 Hoxb5 ENSMUST00000049272.5 homeobox B5 (from RefSeq NM_008268.2) ENSMUST00000049272.1 ENSMUST00000049272.2 ENSMUST00000049272.3 ENSMUST00000049272.4 HXB5_MOUSE Hox-2.1 Hoxb-5 NM_008268 P09079 Q3ZAY8 uc007lbu.1 uc007lbu.2 uc007lbu.3 uc007lbu.4 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. P09079; O35317: Pbx3; NbExp=2; IntAct=EBI-26671239, EBI-26671189; Nucleus. Expressed in a broad spectrum of tissues. Embryo. Belongs to the Antp homeobox family. RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding fibrillar center DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytosol regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification sequence-specific DNA binding endothelial cell differentiation positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system morphogenesis embryonic skeletal system development uc007lbu.1 uc007lbu.2 uc007lbu.3 uc007lbu.4 
ENSMUST00000049281.12 Fam53c ENSMUST00000049281.12 family with sequence similarity 53, member C, transcript variant 1 (from RefSeq NM_175104.5) ENSMUST00000049281.1 ENSMUST00000049281.10 ENSMUST00000049281.11 ENSMUST00000049281.2 ENSMUST00000049281.3 ENSMUST00000049281.4 ENSMUST00000049281.5 ENSMUST00000049281.6 ENSMUST00000049281.7 ENSMUST00000049281.8 ENSMUST00000049281.9 FA53C_MOUSE Fam53c NM_175104 Q3U4J2 Q8BXQ8 uc008eli.1 uc008eli.2 Belongs to the FAM53 family. molecular_function nucleus protein import into nucleus uc008eli.1 uc008eli.2 
ENSMUST00000049285.10 Lrrn1 ENSMUST00000049285.10 leucine rich repeat protein 1, neuronal (from RefSeq NM_008516.4) ENSMUST00000049285.1 ENSMUST00000049285.2 ENSMUST00000049285.3 ENSMUST00000049285.4 ENSMUST00000049285.5 ENSMUST00000049285.6 ENSMUST00000049285.7 ENSMUST00000049285.8 ENSMUST00000049285.9 Kiaa1497 LRRN1_MOUSE NM_008516 Q3USY1 Q61809 Q69ZI0 uc009ddd.1 uc009ddd.2 uc009ddd.3 uc009ddd.4 Membrane ; Single-pass type I membrane protein Expressed in brain. Sequence=BAD32464.1; Type=Erroneous initiation; Evidence=; extracellular space membrane integral component of membrane extracellular matrix positive regulation of synapse assembly uc009ddd.1 uc009ddd.2 uc009ddd.3 uc009ddd.4 
ENSMUST00000049289.9 Ugt1a2 ENSMUST00000049289.9 UDP glucuronosyltransferase 1 family, polypeptide A2 (from RefSeq NM_013701.3) ENSMUST00000049289.1 ENSMUST00000049289.2 ENSMUST00000049289.3 ENSMUST00000049289.4 ENSMUST00000049289.5 ENSMUST00000049289.6 ENSMUST00000049289.7 ENSMUST00000049289.8 NM_013701 P70691 Q545X2 Q6XL49 UD12_MOUSE Ugt1 uc007byi.1 uc007byi.2 uc007byi.3 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Microsome Endoplasmic reticulum membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.; Name=1; IsoId=P70691-1; Sequence=Displayed; Expressed in kidney. Belongs to the UDP-glycosyltransferase family. retinoic acid binding endoplasmic reticulum endoplasmic reticulum membrane glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups enzyme binding protein homodimerization activity intracellular membrane-bounded organelle protein heterodimerization activity cellular glucuronidation flavonoid glucuronidation xenobiotic glucuronidation uc007byi.1 uc007byi.2 uc007byi.3 
ENSMUST00000049294.4 Snrpd2 ENSMUST00000049294.4 small nuclear ribonucleoprotein D2 (from RefSeq NM_026943.2) ENSMUST00000049294.1 ENSMUST00000049294.2 ENSMUST00000049294.3 NM_026943 Q14AF6 Q14AF6_MOUSE SNRPD2 Snrpd2 uc009fkv.1 uc009fkv.2 uc009fkv.3 Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Cytoplasm, cytosol Nucleus Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. Belongs to the snRNP core protein family. nucleus U1 snRNP cytoplasm cytosol mRNA processing RNA splicing small nuclear ribonucleoprotein complex U1 snRNP binding uc009fkv.1 uc009fkv.2 uc009fkv.3 
ENSMUST00000049298.15 Tph1 ENSMUST00000049298.15 tryptophan hydroxylase 1, transcript variant 1 (from RefSeq NM_009414.3) ENSMUST00000049298.1 ENSMUST00000049298.10 ENSMUST00000049298.11 ENSMUST00000049298.12 ENSMUST00000049298.13 ENSMUST00000049298.14 ENSMUST00000049298.2 ENSMUST00000049298.3 ENSMUST00000049298.4 ENSMUST00000049298.5 ENSMUST00000049298.6 ENSMUST00000049298.7 ENSMUST00000049298.8 ENSMUST00000049298.9 NM_009414 Q3UK52 Q3UK52_MOUSE Tph1 uc009gyr.1 uc009gyr.2 uc009gyr.3 uc009gyr.4 This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase family. The encoded protein is one of two tryptophan hydroxylase enzymes that catalyze the first and rate limiting step in the biosynthesis of the hormone and neurotransmitter, serotonin. This gene is expressed in peripheral organs, while tryptophan hydroxylase 2 is expressed in neurons. The encoded protein is involved in the development of hypoxia-induced elevations in pulmonary pressures and pulmonary vascular remodeling, and has also been implicated as a regulator of immune tolerance. Disruption of this gene is associated with cardiac dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]. Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate- determining step of serotonin biosynthesis. Reaction=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5- hydroxy-L-tryptophan; Xref=Rhea:RHEA:16709, ChEBI:CHEBI:15379, ChEBI:CHEBI:15642, ChEBI:CHEBI:57912, ChEBI:CHEBI:58266, ChEBI:CHEBI:59560; EC=1.14.16.4; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence= Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. Homotetramer. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. monooxygenase activity tryptophan 5-monooxygenase activity iron ion binding circadian rhythm aromatic amino acid family metabolic process oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen negative regulation of ossification response to immobilization stress serotonin biosynthetic process neuron projection metal ion binding oxidation-reduction process uc009gyr.1 uc009gyr.2 uc009gyr.3 uc009gyr.4 
ENSMUST00000049304.14 Klra7 ENSMUST00000049304.14 killer cell lectin-like receptor, subfamily A, member 7, transcript variant 2 (from RefSeq NM_014194.5) ENSMUST00000049304.1 ENSMUST00000049304.10 ENSMUST00000049304.11 ENSMUST00000049304.12 ENSMUST00000049304.13 ENSMUST00000049304.2 ENSMUST00000049304.3 ENSMUST00000049304.4 ENSMUST00000049304.5 ENSMUST00000049304.6 ENSMUST00000049304.7 ENSMUST00000049304.8 ENSMUST00000049304.9 KLRA7_MOUSE Ly-49g Ly49-g Ly49g Ly49g4 NM_014194 Q60654 Q60655 Q60656 Q60683 uc009ehx.1 uc009ehx.2 uc009ehx.3 Receptor on natural killer (NK) cells for class I MHC. Homodimer; disulfide-linked. Membrane; Single-pass type II membrane protein. Event=Alternative splicing; Named isoforms=3; Name=Ly-49G.1; IsoId=Q60654-1; Sequence=Displayed; Name=Ly-49G.2; IsoId=Q60654-2; Sequence=VSP_003070; Name=Ly-49G.3; IsoId=Q60654-3; Sequence=VSP_003069; plasma membrane cell adhesion external side of plasma membrane membrane integral component of membrane carbohydrate binding uc009ehx.1 uc009ehx.2 uc009ehx.3 
ENSMUST00000049308.9 Itpr3 ENSMUST00000049308.9 inositol 1,4,5-triphosphate receptor 3 (from RefSeq NM_080553.3) ENSMUST00000049308.1 ENSMUST00000049308.2 ENSMUST00000049308.3 ENSMUST00000049308.4 ENSMUST00000049308.5 ENSMUST00000049308.6 ENSMUST00000049308.7 ENSMUST00000049308.8 ITPR3_MOUSE NM_080553 P70227 Q5DWM4 Q8CED5 Q91Z08 uc008bfi.1 uc008bfi.2 uc008bfi.3 Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Involved in cellular calcium ion homeostasis (By similarity). Homotetramer. Interacts with TRPC1, TRPC3, TRPC4. Interacts with TRPV4 (By similarity). Interacts with SIGMAR1 (PubMed:11149946). Interacts with AKT1 and PML (PubMed:21030605). Interacts with IRAG2 (via coiled-coil domain) (PubMed:20071408). Interacts with CABP1 (By similarity). Interacts with TMBIM4/LFG4 (By similarity). Interacts with CEMIP (By similarity). Interacts with TESPA1 (PubMed:23650607). Interacts with TMEM203 (By similarity). Interacts with BOK; regulates ITPR3 expression (By similarity). Interacts with BCL2L10 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylated on tyrosine residues (By similarity). Phosphorylated by AKT1 on serine and/or threonine residues. Belongs to the InsP3 receptor family. inositol hexakisphosphate binding ion channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity calcium channel activity calcium ion binding protein binding nucleus nuclear envelope nuclear outer membrane nucleoplasm nucleolus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane brush border ion transport calcium ion transport G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration memory calcium-release channel activity membrane integral component of membrane sarcoplasmic reticulum integral component of endoplasmic reticulum membrane dendrite cytoplasmic vesicle membrane secretory granule membrane phosphatidylinositol binding neuronal cell body myelin sheath receptor complex inositol 1,3,4,5 tetrakisphosphate binding apical part of cell inositol phosphate-mediated signaling perinuclear region of cytoplasm sensory perception of bitter taste sensory perception of sweet taste sensory perception of umami taste release of sequestered calcium ion into cytosol protein homooligomerization protein heterooligomerization response to calcium ion transmembrane transport long-term synaptic potentiation calcium ion transport into cytosol calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding cellular response to cAMP presynapse uc008bfi.1 uc008bfi.2 uc008bfi.3 
ENSMUST00000049323.9 Wdr55 ENSMUST00000049323.9 WD repeat domain 55, transcript variant 2 (from RefSeq NR_154585.1) A2RS10 ENSMUST00000049323.1 ENSMUST00000049323.2 ENSMUST00000049323.3 ENSMUST00000049323.4 ENSMUST00000049323.5 ENSMUST00000049323.6 ENSMUST00000049323.7 ENSMUST00000049323.8 NR_154585 Q9CX97 WDR55_MOUSE uc008eol.1 uc008eol.2 uc008eol.3 Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis. Nucleus, nucleolus Cytoplasm Death before implantation of the embryo. Belongs to the WD repeat WDR55 family. molecular_function nucleus nucleolus cytoplasm rRNA processing uc008eol.1 uc008eol.2 uc008eol.3 
ENSMUST00000049324.13 Flt3 ENSMUST00000049324.13 FMS-like tyrosine kinase 3 (from RefSeq NM_010229.2) ENSMUST00000049324.1 ENSMUST00000049324.10 ENSMUST00000049324.11 ENSMUST00000049324.12 ENSMUST00000049324.2 ENSMUST00000049324.3 ENSMUST00000049324.4 ENSMUST00000049324.5 ENSMUST00000049324.6 ENSMUST00000049324.7 ENSMUST00000049324.8 ENSMUST00000049324.9 Flt3 NM_010229 Q3UEW6 Q3UEW6_MOUSE uc009aob.1 uc009aob.2 uc009aob.3 uc009aob.4 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Membrane ingle-pass type I membrane protein Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding nucleus cytoplasm endoplasmic reticulum cytosol plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway response to organonitrogen compound membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation hemopoiesis cell differentiation animal organ regeneration macromolecular complex glucocorticoid receptor binding protein self-association macromolecular complex binding cellular response to glucocorticoid stimulus uc009aob.1 uc009aob.2 uc009aob.3 uc009aob.4 
ENSMUST00000049339.7 Nodal ENSMUST00000049339.7 nodal (from RefSeq NM_013611.5) ENSMUST00000049339.1 ENSMUST00000049339.2 ENSMUST00000049339.3 ENSMUST00000049339.4 ENSMUST00000049339.5 ENSMUST00000049339.6 NM_013611 NODAL_MOUSE P43021 Q8BH87 uc007ffy.1 uc007ffy.2 uc007ffy.3 uc007ffy.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. Homozygous knockout mice for this gene exhibit early embryonic lethality, while expression of a hypomorphic allele results in defects in anteroposterior and left-right patterning. [provided by RefSeq, Aug 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X70514.1, AK049290.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Essential for mesoderm formation and axial patterning during embryonic development. Homodimer; disulfide-linked. Secreted Expressed in the node during gastrulation. Expression is first detected in primitive streak-stage embryos at about the time of mesoderm formation. It then becomes highly localized in the node at the anterior of the primitive streak. Belongs to the TGF-beta family. negative regulation of transcription from RNA polymerase II promoter in utero embryonic development gastrulation with mouth forming second mesoderm formation trophectodermal cell differentiation trophectodermal cellular morphogenesis neural fold formation liver development placenta development embryonic placenta development maternal placenta development vasculature development heart looping inhibition of neuroepithelial cell differentiation cytokine activity transforming growth factor beta receptor binding protein binding extracellular region extracellular space transforming growth factor beta receptor signaling pathway multicellular organism development determination of left/right symmetry gastrulation nervous system development brain development endoderm development heart development growth factor activity positive regulation of cell proliferation embryonic pattern specification anterior/posterior axis specification anterior/posterior pattern specification regulation of signal transduction polarity specification of proximal/distal axis regulation of gastrulation positive regulation of vascular endothelial growth factor production negative regulation of cell development positive regulation of pathway-restricted SMAD protein phosphorylation cell migration stem cell population maintenance positive regulation of cell-cell adhesion lung development BMP signaling pathway positive regulation of activin receptor signaling pathway floor plate morphogenesis embryonic heart tube development endodermal cell differentiation nodal signaling pathway cell migration involved in gastrulation regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of MAPK cascade cell fate commitment negative regulation of cell differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter receptor agonist activity axial mesodermal cell fate specification mesendoderm development cell development digestive tract morphogenesis anatomical structure formation involved in morphogenesis embryonic cranial skeleton morphogenesis tissue morphogenesis formation of anatomical boundary positive regulation of epithelial cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity digestive system development embryonic process involved in female pregnancy maternal process involved in parturition positive regulation of SMAD protein import into nucleus SMAD protein signal transduction left lung morphogenesis negative regulation of androgen receptor signaling pathway epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification positive regulation of ERK1 and ERK2 cascade type I activin receptor binding primitive streak formation transforming growth factor beta receptor signaling pathway involved in primitive streak formation nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry negative regulation of trophoblast cell migration negative regulation of chorionic trophoblast cell proliferation uc007ffy.1 uc007ffy.2 uc007ffy.3 uc007ffy.4 
ENSMUST00000049343.15 Pold1 ENSMUST00000049343.15 polymerase (DNA directed), delta 1, catalytic subunit (from RefSeq NM_011131.3) DPOD1_MOUSE ENSMUST00000049343.1 ENSMUST00000049343.10 ENSMUST00000049343.11 ENSMUST00000049343.12 ENSMUST00000049343.13 ENSMUST00000049343.14 ENSMUST00000049343.2 ENSMUST00000049343.3 ENSMUST00000049343.4 ENSMUST00000049343.5 ENSMUST00000049343.6 ENSMUST00000049343.7 ENSMUST00000049343.8 ENSMUST00000049343.9 NM_011131 O54883 P52431 Pold1 Q3TFX6 uc009gpx.1 uc009gpx.2 uc009gpx.3 uc009gpx.4 As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4. Although both Pol-delta3 and Pol- delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6- methylguanine, 8oxoG or abasic sites. Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Regulated by alteration of quaternary structure. Exhibits burst rates of DNA synthesis are about 5 times faster in the presence of POLD4 (Pol-delta4 complex) than in its absence (Pol-delta3 complex), while the affinity of the enzyme for its DNA and dNTP substrates appears unchanged. The Pol-delta3 complex is more likely to proofread DNA synthesis because it cleaves single-stranded DNA twice as fast and transfers mismatched DNA from the polymerase to the exonuclease sites 9 times faster compared to the Pol-delta3 complex. Pol-delta3 also extends mismatched primers 3 times more slowly in the absence of POLD4. The conversion of Pol-delta4 into Pol-delta3 is induced by genotoxic stress or by replication stress leading POLD4 degradation. Stimulated in the presence of PCNA (By similarity). This stimulation is further increased in the presence of KCTD13/PDIP1, most probably via direct interaction between KCTD13 and POLD2 (By similarity). Component of the tetrameric DNA polymerase delta complex (Pol- delta4), which consists of POLD1/p125, POLD2/p50, POLD3/p66/p68 and POLD4/p12, with POLD1 bearing both DNA polymerase and 3' to 5' proofreading exonuclease activities. Within Pol-delta4, directly interacts with POLD2 and POLD4. Following genotoxic stress by DNA- damaging agents, such as ultraviolet light and methyl methanesulfonate, or by replication stress induced by treatment with hydroxyurea or aphidicolin, Pol-delta4 is converted into a trimeric form of the complex (Pol-delta3) by POLD4 degradation. Pol-delta3 is the major form at S phase replication sites and DNA damage sites. POLD1 displays different catalytic properties depending upon the complex it is found in. It exhibits higher proofreading activity and fidelity than Pol- delta4, making it particularly well suited to respond to DNA damage. Directly interacts with PCNA, as do POLD3 and POLD4; this interaction stimulates Pol-delta4 polymerase activity. As POLD2 and POLD4, directly interacts with WRNIP1; this interaction stimulates DNA polymerase delta-mediated DNA synthesis, independently of the presence of PCNA. This stimulation may be due predominantly to an increase of initiation frequency and also to increased processivity. Also observed as a dimeric complex with POLD2 (Pol-delta2). Pol-delta2 is relatively insensitive to the PCNA stimulation (2-5-fold) compared to Pol-delta4 that is stimulated by over 50-fold. The DNA polymerase delta complex interacts with POLDIP2; this interaction is probably mediated through direct binding to POLD2. Interacts with CIAO1. Interacts with POLDIP2 (By similarity). Nucleus Note=Colocalizes with PCNA and POLD3 at S phase replication sites. After UV irradiation, recruited to DNA damage sites within 2 hours, independently on the cell cycle phase, nor on PCNA ubiquitination. This recruitment requires POLD3, PCNA and RFC1-replication factor C complex. The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes. Belongs to the DNA polymerase type-B family. nucleotide-excision repair complex nucleotide binding DNA synthesis involved in DNA repair nucleic acid binding DNA binding chromatin binding damaged DNA binding DNA-directed DNA polymerase activity nuclease activity exonuclease activity nucleus nucleoplasm cytosol DNA replication DNA-dependent DNA replication DNA repair base-excision repair, gap-filling nucleotide-excision repair, DNA gap filling cellular response to DNA damage stimulus 3'-5'-exodeoxyribonuclease activity 3'-5' exonuclease activity aggresome transferase activity nucleotidyltransferase activity hydrolase activity enzyme binding cellular response to UV delta DNA polymerase complex DNA replication proofreading metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding fatty acid homeostasis DNA biosynthetic process nucleic acid phosphodiester bond hydrolysis nuclear chromosome, telomeric region uc009gpx.1 uc009gpx.2 uc009gpx.3 uc009gpx.4 
ENSMUST00000049344.15 Csgalnact2 ENSMUST00000049344.15 chondroitin sulfate N-acetylgalactosaminyltransferase 2, transcript variant 2 (from RefSeq NM_030165.3) CGAT2_MOUSE Chgn2 ENSMUST00000049344.1 ENSMUST00000049344.10 ENSMUST00000049344.11 ENSMUST00000049344.12 ENSMUST00000049344.13 ENSMUST00000049344.14 ENSMUST00000049344.2 ENSMUST00000049344.3 ENSMUST00000049344.4 ENSMUST00000049344.5 ENSMUST00000049344.6 ENSMUST00000049344.7 ENSMUST00000049344.8 ENSMUST00000049344.9 Galnact2 NM_030165 Q6PAP6 Q8C1F4 Q8R5A2 Q9D2M1 uc009dll.1 uc009dll.2 uc009dll.3 Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains (By similarity). Reaction=3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)- beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta- D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23464, Rhea:RHEA-COMP:12573, Rhea:RHEA-COMP:12575, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:132093, ChEBI:CHEBI:132105; EC=2.4.1.174; Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Belongs to the chondroitin N- acetylgalactosaminyltransferase family. Golgi apparatus acetylgalactosaminyltransferase activity membrane integral component of membrane transferase activity proteoglycan biosynthetic process Golgi cisterna membrane metal ion binding glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity chondroitin sulfate proteoglycan biosynthetic process dermatan sulfate proteoglycan biosynthetic process uc009dll.1 uc009dll.2 uc009dll.3 
ENSMUST00000049348.9 Traip ENSMUST00000049348.9 TRAF-interacting protein, transcript variant 6 (from RefSeq NR_177076.1) ENSMUST00000049348.1 ENSMUST00000049348.2 ENSMUST00000049348.3 ENSMUST00000049348.4 ENSMUST00000049348.5 ENSMUST00000049348.6 ENSMUST00000049348.7 ENSMUST00000049348.8 NR_177076 O08854 Q8VIG6 Q922M8 Q9CPP4 TRAIP_MOUSE Traip Trip uc009rnn.1 uc009rnn.2 uc009rnn.3 E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:33590678). Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). During mitosis, controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (PubMed:33590678). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (By similarity). The function in translesion synthesis is however controversial (By similarity). Acts as a regulator of the spindle assembly checkpoint (By similarity). Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:17544371, PubMed:22945920). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence= Protein modification; protein ubiquitination. Interacts (via PIP-box) with PCNA (By similarity). Binds TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 is part of the receptor-TRAF signaling complex (PubMed:17544371, PubMed:9104814). May interact with CYLD; the C-terminus interacts with CYLD, however the interaction was not detected with the full-length protein (By similarity). Interacts with POLK and POLN (By similarity). Interacts with UIMC1 (By similarity). Nucleus, nucleoplasm Nucleus, nucleolus Chromosome Cytoplasm Cytoplasm, perinuclear region Note=In the nucleus, found in close proximity to PCNA, suggesting localization at replication foci (PubMed:33590678). Localizes to DNA damage sites in response to replication stress (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VIG6-1; Sequence=Displayed; Name=2; IsoId=Q8VIG6-2; Sequence=VSP_007406, VSP_007407; Detected in testis and thymus, and at lower levels in spleen. Expressed during oocytes meiosis. Autoubiquitinated. Sumoylated; sumoylation is required for nuclear localization. Sumoylation increases protein stability, possibly by preventing ubiquitination. Early embryonic lethality due to proliferation defects and excessive cell death (PubMed:17927961). TRAIP knockdown substantially increases LPS- and poly(I:C)-induced IFN-production in mouse peritoneal macrophages at both mRNA and protein levels (PubMed:22945920). Belongs to the TRAIP family. ubiquitin-protein transferase activity protein binding nucleus nucleolus cytoplasm signal transduction negative regulation of tumor necrosis factor-mediated signaling pathway protein ubiquitination transferase activity negative regulation of NF-kappaB transcription factor activity negative regulation of interferon-beta production metal ion binding perinuclear region of cytoplasm ubiquitin protein ligase activity uc009rnn.1 uc009rnn.2 uc009rnn.3 
ENSMUST00000049352.8 Hoxb7 ENSMUST00000049352.8 homeobox B7 (from RefSeq NM_010460.2) A2A9Z9 ENSMUST00000049352.1 ENSMUST00000049352.2 ENSMUST00000049352.3 ENSMUST00000049352.4 ENSMUST00000049352.5 ENSMUST00000049352.6 ENSMUST00000049352.7 HXB7_MOUSE Hox-2.3 Hoxb-7 NM_010460 P09024 Q3UW15 uc007lbr.1 uc007lbr.2 uc007lbr.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Forms a DNA-binding heterodimer with transcription factor PBX1. Nucleus. Belongs to the Antp homeobox family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification nuclear body myeloid cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system morphogenesis positive regulation of branching involved in ureteric bud morphogenesis uc007lbr.1 uc007lbr.2 uc007lbr.3 
ENSMUST00000049355.11 Mapk6 ENSMUST00000049355.11 mitogen-activated protein kinase 6, transcript variant 1 (from RefSeq NM_015806.5) ENSMUST00000049355.1 ENSMUST00000049355.10 ENSMUST00000049355.2 ENSMUST00000049355.3 ENSMUST00000049355.4 ENSMUST00000049355.5 ENSMUST00000049355.6 ENSMUST00000049355.7 ENSMUST00000049355.8 ENSMUST00000049355.9 Erk3 MK06_MOUSE NM_015806 Prkm4 Prkm6 Q497T9 Q61532 Q6YKB0 Q7TT30 Q80XH5 Q922U4 Q9JLU6 uc009qse.1 uc009qse.2 uc009qse.3 uc009qse.4 Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation at Ser-189. Heterodimer with ERK4/MAPK4. Interacts with (via FRIEDE motif) MAPKAPK5. Interacts with UBE3A; this interaction may be indirect and mediated by HERC2, possibly via HERC2 interaction with NEURL4 (By similarity). Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. Expression increases markedly from days 9 to 11 in the developing embryo, followed by a gradual decrease up to birth. In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose phosphorylation activates the MAP kinases. Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. Ubiquitination at Met-1 leads to degradation by the proteasome pathway. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. MAPK cascade nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity protein binding ATP binding nucleus cytoplasm cytosol protein phosphorylation cell cycle regulation of gene expression kinase activity phosphorylation transferase activity protein kinase binding septin cytoskeleton macromolecular complex intracellular signal transduction protein heterodimerization activity positive regulation of dendritic spine development cellular response to organic substance uc009qse.1 uc009qse.2 uc009qse.3 uc009qse.4 
ENSMUST00000049357.10 Pnrc1 ENSMUST00000049357.10 proline-rich nuclear receptor coactivator 1 (from RefSeq NM_001033225.2) ENSMUST00000049357.1 ENSMUST00000049357.2 ENSMUST00000049357.3 ENSMUST00000049357.4 ENSMUST00000049357.5 ENSMUST00000049357.6 ENSMUST00000049357.7 ENSMUST00000049357.8 ENSMUST00000049357.9 NM_001033225 Pnrc1 Q3TWH3 Q3TWH3_MOUSE uc008sfu.1 uc008sfu.2 uc008sfu.3 Nucleus molecular_function nucleus uc008sfu.1 uc008sfu.2 uc008sfu.3 
ENSMUST00000049369.16 Stn1 ENSMUST00000049369.16 STN1, CST complex subunit (from RefSeq NM_175360.3) ENSMUST00000049369.1 ENSMUST00000049369.10 ENSMUST00000049369.11 ENSMUST00000049369.12 ENSMUST00000049369.13 ENSMUST00000049369.14 ENSMUST00000049369.15 ENSMUST00000049369.2 ENSMUST00000049369.3 ENSMUST00000049369.4 ENSMUST00000049369.5 ENSMUST00000049369.6 ENSMUST00000049369.7 ENSMUST00000049369.8 ENSMUST00000049369.9 NM_175360 Obfc1 Q3TPH0 Q8C6I6 Q8K2X3 STN1_MOUSE Stn1 uc008hvb.1 uc008hvb.2 uc008hvb.3 Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22748632). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging- strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity). Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1; in the complex interacts directly with TEN1 and CTC1 (PubMed:19119139, PubMed:19854130). Interacts with ACD/TPP1 (PubMed:19648609). Interacts with POT1 and POLA1 (By similarity). Q8K2X3; Q5EE38: Acd; NbExp=2; IntAct=EBI-2553883, EBI-6258642; Nucleus romosome, telomere Belongs to the STN1 family. According to PubMed:19119139, it acts as a regulator of DNA replication. According to PubMed:19854130, this effect is indirect and it rather acts as a general regulator of DNA metabolism. Sequence=AAH29548.1; Type=Erroneous initiation; Evidence=; telomere maintenance double-strand break repair via homologous recombination chromosome, telomeric region nuclear chromosome, telomeric region fibrillar center nucleic acid binding DNA binding single-stranded DNA binding protein binding nucleus nucleoplasm DNA replication factor A complex chromosome DNA replication DNA repair nucleotide-excision repair telomere maintenance via telomere lengthening telomere capping negative regulation of telomere maintenance via telomerase site of double-strand break telomeric DNA binding single-stranded telomeric DNA binding intracellular membrane-bounded organelle intermediate filament cytoskeleton positive regulation of DNA replication CST complex uc008hvb.1 uc008hvb.2 uc008hvb.3 
ENSMUST00000049385.14 Eif1 ENSMUST00000049385.14 eukaryotic translation initiation factor 1 (from RefSeq NM_011508.2) ENSMUST00000049385.1 ENSMUST00000049385.10 ENSMUST00000049385.11 ENSMUST00000049385.12 ENSMUST00000049385.13 ENSMUST00000049385.2 ENSMUST00000049385.3 ENSMUST00000049385.4 ENSMUST00000049385.5 ENSMUST00000049385.6 ENSMUST00000049385.7 ENSMUST00000049385.8 ENSMUST00000049385.9 Eif1 NM_011508 Q4V9T8 Q4V9T8_MOUSE Sui1-rs1 uc007lkv.1 uc007lkv.2 uc007lkv.3 uc007lkv.4 Cytoplasm Belongs to the SUI1 family. translation initiation factor activity nucleus cytoplasm translational initiation regulation of translational initiation uc007lkv.1 uc007lkv.2 uc007lkv.3 uc007lkv.4 
ENSMUST00000049388.9 Commd10 ENSMUST00000049388.9 COMM domain containing 10, transcript variant 14 (from RefSeq NR_184828.1) COMDA_MOUSE ENSMUST00000049388.1 ENSMUST00000049388.2 ENSMUST00000049388.3 ENSMUST00000049388.4 ENSMUST00000049388.5 ENSMUST00000049388.6 ENSMUST00000049388.7 ENSMUST00000049388.8 NR_184828 Q8JZY2 uc008evz.1 uc008evz.2 uc008evz.3 uc008evz.4 May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL7. Cytoplasm Nucleus molecular_function cellular_component nucleus cytoplasm biological_process uc008evz.1 uc008evz.2 uc008evz.3 uc008evz.4 
ENSMUST00000049393.15 Zfp113 ENSMUST00000049393.15 zinc finger protein 113 (from RefSeq NM_019747.4) ENSMUST00000049393.1 ENSMUST00000049393.10 ENSMUST00000049393.11 ENSMUST00000049393.12 ENSMUST00000049393.13 ENSMUST00000049393.14 ENSMUST00000049393.2 ENSMUST00000049393.3 ENSMUST00000049393.4 ENSMUST00000049393.5 ENSMUST00000049393.6 ENSMUST00000049393.7 ENSMUST00000049393.8 ENSMUST00000049393.9 NM_019747 Q8C689 Q8C689_MOUSE Zfp113 uc009aeq.1 uc009aeq.2 uc009aeq.3 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated identical protein binding metal ion binding uc009aeq.1 uc009aeq.2 uc009aeq.3 
ENSMUST00000049395.15 Ttc29 ENSMUST00000049395.15 tetratricopeptide repeat domain 29 (from RefSeq NM_183096.3) E9QLU4 E9QLU4_MOUSE ENSMUST00000049395.1 ENSMUST00000049395.10 ENSMUST00000049395.11 ENSMUST00000049395.12 ENSMUST00000049395.13 ENSMUST00000049395.14 ENSMUST00000049395.2 ENSMUST00000049395.3 ENSMUST00000049395.4 ENSMUST00000049395.5 ENSMUST00000049395.6 ENSMUST00000049395.7 ENSMUST00000049395.8 ENSMUST00000049395.9 NM_183096 Ttc29 uc009mhx.1 uc009mhx.2 Axonemal protein which is implicated in axonemal and/or peri- axonemal structures assembly and regulates flagella assembly and beating and therefore sperm motility. Cytoplasm, cytoskeleton, flagellum axoneme uc009mhx.1 uc009mhx.2 
ENSMUST00000049400.15 Kank1 ENSMUST00000049400.15 KN motif and ankyrin repeat domains 1, transcript variant 1 (from RefSeq NM_181404.7) E9Q238 E9Q238_MOUSE ENSMUST00000049400.1 ENSMUST00000049400.10 ENSMUST00000049400.11 ENSMUST00000049400.12 ENSMUST00000049400.13 ENSMUST00000049400.14 ENSMUST00000049400.2 ENSMUST00000049400.3 ENSMUST00000049400.4 ENSMUST00000049400.5 ENSMUST00000049400.6 ENSMUST00000049400.7 ENSMUST00000049400.8 ENSMUST00000049400.9 Kank1 NM_181404 uc008hbf.1 uc008hbf.2 uc008hbf.3 nucleus cytoplasm plasma membrane beta-catenin binding cell proliferation negative regulation of neuron projection development actin cytoskeleton organization positive regulation of Wnt signaling pathway negative regulation of cell migration negative regulation of actin filament polymerization ruffle membrane regulation of Rho protein signal transduction negative regulation of Rho protein signal transduction negative regulation of insulin receptor signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of wound healing glomerular visceral epithelial cell migration negative regulation of substrate adhesion-dependent cell spreading negative regulation of ruffle assembly regulation of establishment of cell polarity negative regulation of lamellipodium morphogenesis uc008hbf.1 uc008hbf.2 uc008hbf.3 
ENSMUST00000049411.12 Apex1 ENSMUST00000049411.12 apurinic/apyrimidinic endonuclease 1 (from RefSeq NM_009687.2) Apex1 ENSMUST00000049411.1 ENSMUST00000049411.10 ENSMUST00000049411.11 ENSMUST00000049411.2 ENSMUST00000049411.3 ENSMUST00000049411.4 ENSMUST00000049411.5 ENSMUST00000049411.6 ENSMUST00000049411.7 ENSMUST00000049411.8 ENSMUST00000049411.9 NM_009687 Q544Z7 Q544Z7_MOUSE uc007tly.1 uc007tly.2 uc007tly.3 uc007tly.4 Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.2; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= Note=Probably binds two magnesium or manganese ions per subunit. ; Nucleus Cytoplasm Mitochondrion Belongs to the DNA repair enzymes AP/ExoA family. telomere maintenance DNA binding damaged DNA binding double-stranded telomeric DNA binding transcription coactivator activity DNA-(apurinic or apyrimidinic site) lyase activity nuclease activity endonuclease activity endoribonuclease activity nucleus nucleoplasm transcription factor complex nucleolus cytoplasm mitochondrion centrosome DNA repair base-excision repair cellular response to DNA damage stimulus aging phosphoric diester hydrolase activity double-stranded DNA exodeoxyribonuclease activity 3'-5' exonuclease activity response to organonitrogen compound negative regulation of smooth muscle cell migration oxidoreductase activity nuclear speck hydrolase activity lyase activity site-specific endodeoxyribonuclease activity, specific for altered base chromatin DNA binding response to drug regulation of apoptotic process regulation of mRNA stability macromolecular complex binding metal ion binding perinuclear region of cytoplasm NF-kappaB binding oxidation-reduction process cellular response to hydrogen peroxide cellular response to cAMP cellular response to peptide hormone stimulus cellular response to organonitrogen compound DNA demethylation nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic telomere maintenance via base-excision repair positive regulation of G1/S transition of mitotic cell cycle positive regulation of nucleic acid-templated transcription uc007tly.1 uc007tly.2 uc007tly.3 uc007tly.4 
ENSMUST00000049420.4 Tsga8 ENSMUST00000049420.4 testis specific gene A8 (from RefSeq NM_021898.2) C4IXT6 ENSMUST00000049420.1 ENSMUST00000049420.2 ENSMUST00000049420.3 Halapx NM_021898 Q9JJL0 TSGA8_MOUSE Tsga8 uc009trk.1 uc009trk.2 uc009trk.3 uc009trk.4 uc009trk.5 Cytoplasm Nucleus, nucleoplasm Note=Strongly expressed in the nucleus of round spermatids. As spermatids mature, nuclear expression declines and cytoplasmic expression increases. Elongating spermatids have mainly cytoplasmic expression. Specifically expressed in testis (at protein level). Detected in testis from 18 days onwards. In developing spermatazoa, expressed from the round spermatid stage through to the terminal stages of spermiogenesis, when expression declines. Sequence=AAI39063.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function nucleus nucleoplasm cytoplasm biological_process uc009trk.1 uc009trk.2 uc009trk.3 uc009trk.4 uc009trk.5 
ENSMUST00000049424.11 Wdr74 ENSMUST00000049424.11 WD repeat domain 74 (from RefSeq NM_134139.1) ENSMUST00000049424.1 ENSMUST00000049424.10 ENSMUST00000049424.2 ENSMUST00000049424.3 ENSMUST00000049424.4 ENSMUST00000049424.5 ENSMUST00000049424.6 ENSMUST00000049424.7 ENSMUST00000049424.8 ENSMUST00000049424.9 NM_134139 Q8VCG3 WDR74_MOUSE uc008gmm.1 uc008gmm.2 Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (By similarity). Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (PubMed:21799883). Isoform 1 interacts (through WDR repeats) with NVL; the interaction is independent of RNA or pre-60S ribosome particles. Isoform 2 does not interact with NVL. Interacts with MTREX; the interaction dissociation in a late stage of rRNA synthesis is required for appropriate maturation of pre-60S particles and depends on the ATPase activity of NVL. Nucleus, nucleolus Nucleus Note=Nucleolar location depends on active PolI transcription of pre- rRNA. Expressed at low levels in MII oocytes and 1-cell embryos and increases through subsequent cleavage stage divisions. The peak of mRNA expression occurs at the morula stage, with a slight decrease in blastocyst embryos. nuclear exosome (RNase complex) blastocyst formation molecular_function nucleus nucleolus rRNA processing RNA metabolic process preribosome, large subunit precursor ribosomal large subunit biogenesis uc008gmm.1 uc008gmm.2 
ENSMUST00000049449.11 Ptpn7 ENSMUST00000049449.11 protein tyrosine phosphatase, non-receptor type 7, transcript variant 1 (from RefSeq NM_177081.4) ENSMUST00000049449.1 ENSMUST00000049449.10 ENSMUST00000049449.2 ENSMUST00000049449.3 ENSMUST00000049449.4 ENSMUST00000049449.5 ENSMUST00000049449.6 ENSMUST00000049449.7 ENSMUST00000049449.8 ENSMUST00000049449.9 NM_177081 PTN7_MOUSE Q8BUM3 uc007css.1 uc007css.2 uc007css.3 May play a role in the regulation of T and B-lymphocyte development and signal transduction. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Inhibited upon FCER1A triggering. Cytoplasm Cytoplasm, cytoskeleton Note=Oxidized form is preferentially associated with actin cytoskeleton. Expressed in bone marrow-derived mast cells. Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H(2)O(2)) or with antigen enhanced oxidation of active site cysteine. Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytoplasm cytosol cytoskeleton protein dephosphorylation cytoplasmic side of plasma membrane dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc007css.1 uc007css.2 uc007css.3 
ENSMUST00000049453.9 Ube3c ENSMUST00000049453.9 ubiquitin protein ligase E3C (from RefSeq NM_133907.3) ENSMUST00000049453.1 ENSMUST00000049453.2 ENSMUST00000049453.3 ENSMUST00000049453.4 ENSMUST00000049453.5 ENSMUST00000049453.6 ENSMUST00000049453.7 ENSMUST00000049453.8 Kiaa0010 Kiaa10 NM_133907 Q0VB95 Q80U95 Q8BQZ6 Q8C7W6 Q8CDJ1 Q8VDL5 UBE3C_MOUSE Ube3c uc008wun.1 uc008wun.2 uc008wun.3 E3 ubiquitin-protein ligase that specifically catalyzes 'Lys- 29'- and 'Lys-48'-linked polyubiquitin chains (By similarity). Accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the 26S proteasome (By similarity). Also catalyzes 'Lys-29'- and 'Lys-48'- linked ubiquitination of 26S proteasome subunit ADRM1/RPN13 in response to proteotoxic stress, impairing the ability of the proteasome to bind and degrade ubiquitin-conjugated proteins (By similarity). Acts as a negative regulator of autophagy by mediating 'Lys-29'- and 'Lys-48'- linked ubiquitination of PIK3C3/VPS34, promoting its degradation (By similarity). Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains; with some preference for 'Lys-48' linkages (By similarity). Acts as a negative regulator of type I interferon by mediating 'Lys-48'-linked ubiquitination of IRF3 and IRF7, leading to their degradation by the proteasome (PubMed:21167755). Catalyzes ubiquitination and degradation of CAND2 (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence=; Protein modification; protein ubiquitination. Interacts with 26S proteasomes. Interacts (via the HECT domain) with UBE2D1 and, less efficiently, with UBE2L3. Autoubiquitinated; promoting its own degradation. Belongs to the UBE3C family. Sequence=AAH21525.1; Type=Erroneous initiation; Evidence=; protein polyubiquitination ubiquitin-protein transferase activity nucleus ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity ubiquitin conjugating enzyme activity uc008wun.1 uc008wun.2 uc008wun.3 
ENSMUST00000049454.6 Six5 ENSMUST00000049454.6 sine oculis-related homeobox 5 (from RefSeq NM_011383.1) Dmahp ENSMUST00000049454.1 ENSMUST00000049454.2 ENSMUST00000049454.3 ENSMUST00000049454.4 ENSMUST00000049454.5 NM_011383 P70178 SIX5_MOUSE uc009fkr.1 uc009fkr.2 uc009fkr.3 Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3. Probably binds DNA dimer. Interacts with EYA3, and probably EYA1 and EYA2. Nucleus Belongs to the SIX/Sine oculis homeobox family. transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding lens development in camera-type eye DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated multicellular organism development spermatid development negative regulation of cell proliferation sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter anatomical structure development negative regulation of skeletal muscle satellite cell proliferation uc009fkr.1 uc009fkr.2 uc009fkr.3 
ENSMUST00000049461.7 Cars2 ENSMUST00000049461.7 cysteinyl-tRNA synthetase 2, mitochondrial, transcript variant 2 (from RefSeq NM_024248.1) Cars2 ENSMUST00000049461.1 ENSMUST00000049461.2 ENSMUST00000049461.3 ENSMUST00000049461.4 ENSMUST00000049461.5 ENSMUST00000049461.6 G3X975 G3X975_MOUSE NM_024248 uc009kvj.1 uc009kvj.2 uc009kvj.3 uc009kvj.4 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; nucleotide binding aminoacyl-tRNA ligase activity cysteine-tRNA ligase activity ATP binding tRNA aminoacylation for protein translation cysteinyl-tRNA aminoacylation uc009kvj.1 uc009kvj.2 uc009kvj.3 uc009kvj.4 
ENSMUST00000049463.4 Prl3a1 ENSMUST00000049463.4 prolactin family 3, subfamily a, member 1 (from RefSeq NM_025896.3) ENSMUST00000049463.1 ENSMUST00000049463.2 ENSMUST00000049463.3 Ghd9 NM_025896 Plpi Prl3a1 Prlpi Q78Y73 Q78Y73_MOUSE uc007pxj.1 uc007pxj.2 uc007pxj.3 Secreted Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pxj.1 uc007pxj.2 uc007pxj.3 
ENSMUST00000049470.11 Tmem183a ENSMUST00000049470.11 transmembrane protein 183A, transcript variant 1 (from RefSeq NM_020588.2) ENSMUST00000049470.1 ENSMUST00000049470.10 ENSMUST00000049470.2 ENSMUST00000049470.3 ENSMUST00000049470.4 ENSMUST00000049470.5 ENSMUST00000049470.6 ENSMUST00000049470.7 ENSMUST00000049470.8 ENSMUST00000049470.9 MNCb-2755 NM_020588 Q3THC8 Q99LK6 Q9JJB9 TM183_MOUSE Tmem183 uc007crq.1 uc007crq.2 uc007crq.3 Membrane ; Single-pass membrane protein Belongs to the TMEM183 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007crq.1 uc007crq.2 uc007crq.3 
ENSMUST00000049474.9 Fbxw8 ENSMUST00000049474.9 F-box and WD-40 domain protein 8 (from RefSeq NM_172721.2) ENSMUST00000049474.1 ENSMUST00000049474.2 ENSMUST00000049474.3 ENSMUST00000049474.4 ENSMUST00000049474.5 ENSMUST00000049474.6 ENSMUST00000049474.7 ENSMUST00000049474.8 FBXW8_MOUSE NM_172721 Q8BI62 Q8BI75 Q8BI76 Q8BIA4 Q8CID8 Q921Z1 uc008zge.1 uc008zge.2 uc008zge.3 Substrate-recognition component of a Cul7-RING ubiquitin- protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7- RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity). Protein modification; protein ubiquitination. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN. Interacts with OBSL1, CUL1, CUL2, SKP1, CCT6B, PFDN5, CCT2, CCT3, CCT6A, CCT7, VBP1, CCDC8, ARF1, TRIP13, PDCD5 and GORASP1. Interacts with MAP4K1/HPK1 (when autophosphorylated). Associated component of the 3M complex (By similarity). Interacts with CUL7. Interacts with POUF51 (when phosphorylated on 'Ser-347') (PubMed:29153991). Cytoplasm, perinuclear region Golgi apparatus Note=Colocalizes with CUL7 at the Golgi apparatus in neurons. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BIA4-1; Sequence=Displayed; Name=2; IsoId=Q8BIA4-4; Sequence=VSP_008502; Widely expressed. Expressed at higher level in skeletal muscle, cartilage and lung. Reduced embryo size and neonatal lethality. Embryos and placentas are smaller and only a third of the expected number of mice survived birth. Mice that survive remain smaller throughout postnatal development. protein binding cytoplasm Golgi apparatus cytosol ubiquitin-dependent protein catabolic process Golgi organization cell proliferation protein ubiquitination SCF ubiquitin ligase complex preribosome, large subunit precursor Cul7-RING ubiquitin ligase complex perinuclear region of cytoplasm positive regulation of dendrite morphogenesis spongiotrophoblast layer development labyrinthine layer blood vessel development PeBoW complex positive regulation of transcription factor catabolic process 3M complex ubiquitin-protein transferase activity uc008zge.1 uc008zge.2 uc008zge.3 
ENSMUST00000049476.3 Aadacl2fm1 ENSMUST00000049476.3 AADACL2 family member 1 (from RefSeq NM_177661.3) Aadacl2fm1 C130079G13Rik ENSMUST00000049476.1 ENSMUST00000049476.2 NM_177661 Q8BUY2 Q8BUY2_MOUSE uc008pix.1 uc008pix.2 cellular_component catabolic process hydrolase activity short-chain carboxylesterase activity uc008pix.1 uc008pix.2 
ENSMUST00000049483.14 Fmnl2 ENSMUST00000049483.14 formin-like 2, transcript variant 3 (from RefSeq NM_172409.3) ENSMUST00000049483.1 ENSMUST00000049483.10 ENSMUST00000049483.11 ENSMUST00000049483.12 ENSMUST00000049483.13 ENSMUST00000049483.2 ENSMUST00000049483.3 ENSMUST00000049483.4 ENSMUST00000049483.5 ENSMUST00000049483.6 ENSMUST00000049483.7 ENSMUST00000049483.8 ENSMUST00000049483.9 F8VPR2 F8VPR2_MOUSE Fmnl2 NM_172409 uc008jrh.1 uc008jrh.2 uc008jrh.3 Belongs to the formin homology family. actin binding cytoskeleton organization cellular component organization Rho GTPase binding regulation of cell morphogenesis actin cytoskeleton organization cortical actin cytoskeleton organization uc008jrh.1 uc008jrh.2 uc008jrh.3 
ENSMUST00000049488.9 Serinc5 ENSMUST00000049488.9 serine incorporator 5 (from RefSeq NM_172588.2) Aigp3 ENSMUST00000049488.1 ENSMUST00000049488.2 ENSMUST00000049488.3 ENSMUST00000049488.4 ENSMUST00000049488.5 ENSMUST00000049488.6 ENSMUST00000049488.7 ENSMUST00000049488.8 NM_172588 Q80ZH8 Q8BHJ6 Q8CHM0 SERC5_MOUSE uc007rkt.1 uc007rkt.2 uc007rkt.3 uc007rkt.4 Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity). Cell membrane ; Multi-pass membrane protein Note=Localizes to the cell membrane, where it is efficiently incorporated into budding gammaretrovirus virions and impairs subsequent virion penetration of susceptible target cells. Belongs to the TDE1 family. immune system process Golgi apparatus plasma membrane lipid metabolic process phosphatidylserine metabolic process sphingolipid metabolic process phospholipid biosynthetic process detection of virus membrane integral component of membrane myelination myelin sheath innate immune response defense response to virus positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity positive regulation of serine C-palmitoyltransferase activity uc007rkt.1 uc007rkt.2 uc007rkt.3 uc007rkt.4 
ENSMUST00000049501.10 Ofd1 ENSMUST00000049501.10 OFD1, centriole and centriolar satellite protein, transcript variant 1 (from RefSeq NM_177429.4) ENSMUST00000049501.1 ENSMUST00000049501.2 ENSMUST00000049501.3 ENSMUST00000049501.4 ENSMUST00000049501.5 ENSMUST00000049501.6 ENSMUST00000049501.7 ENSMUST00000049501.8 ENSMUST00000049501.9 NM_177429 OFD1_MOUSE Q80Z25 uc009uwr.1 uc009uwr.2 uc009uwr.3 uc009uwr.4 Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation. Homooligomer. Interacts with LCA5. Interacts with RUVBL1; the interaction is direct and may mediate interaction with the NuA4 histone acetyltransferase complex. Interacts with SDCCAG8; the interaction is direct. Interacts with MAP1LC3B. Interacts with C2CD3; OFD1 may act as a negative regulator of C2CD3. Forms a complex with KIAA0753/OFIP and CEP20/FOR20; the interaction with CEP20 is detected only in the presence of KIAA0753. Interacts with PCM1; this interaction may be mediated by KIAA0753/OFIP (PubMed:26643951). Interacts with TBC1D31; regulates OFD1 activity in cilium assembly (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cytoplasm, cytoskeleton, cilium basal body Nucleus Note=Localizes to centriole distal ends and to centriolar satellites (PubMed:20230748, PubMed:24089205). Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP (By similarity). Phosphorylated. Phosphorylation at Ser-737, by the cAMP-dependent protein kinase PKA, triggers ubiquitination and proteasomal degradation of OFD1. Also increases its interaction with TBC1D31 and regulates its function in ciliogenesis. Ubiquitinated by PJA2, upon phosphorylation at Ser-737 by PKA, leads to the proteasomal degradation of OFD1. Females die at birth and display severe craniofacial and limb abnormalities associated with disorganization of the brain, reduction of the lungs, defects in the great vessels and cystic kidney. Primary cilia are absent on the luminal surface of glomerular and tubular cells of kidneys. Males die earlier during development of the embryo, display failure of left right axis specification associated with a lack of cilia in the embryonic node. Belongs to the OFD1 family. extracellular region nucleus cytoplasm centrosome centriole microtubule organizing center cytoskeleton cilium embryonic body morphogenesis cell projection organization centriolar satellite axoneme assembly ciliary basal body identical protein binding cell projection alpha-tubulin binding gamma-tubulin binding cilium assembly epithelial cilium movement involved in determination of left/right asymmetry negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation mitotic cell cycle centriole replication mitotic spindle assembly uc009uwr.1 uc009uwr.2 uc009uwr.3 uc009uwr.4 
ENSMUST00000049507.6 Pcsk9 ENSMUST00000049507.6 proprotein convertase subtilisin/kexin type 9 (from RefSeq NM_153565.2) B1AZI4 ENSMUST00000049507.1 ENSMUST00000049507.2 ENSMUST00000049507.3 ENSMUST00000049507.4 ENSMUST00000049507.5 NM_153565 Narc1 PCSK9_MOUSE Q3UEH7 Q80W65 Q8BXW9 Q8CFT6 uc008tyi.1 uc008tyi.2 uc008tyi.3 uc008tyi.4 Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)- mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Its proteolytic activity is autoinhibited by the non-covalent binding of the propeptide to the catalytic domain. Inhibited by EGTA. Monomer. Can self-associate to form dimers and higher multimers which may have increased LDLR degrading activity. The precursor protein but not the mature protein may form multimers. Interacts with APOB, VLDLR, LRP8/APOER2 and BACE1. The full-length immature form (pro-PCSK9) interacts with SCNN1A, SCNN1B and SCNN1G. The pro-PCSK9 form (via C-terminal domain) interacts with LDLR. Interacts (via the C-terminal domain) with ANXA2 (via repeat Annexin 1); the interaction inhibits the degradation of LDLR. Cytoplasm Secreted. Endosome Lysosome Cell surface Endoplasmic reticulum Golgi apparatus Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and co-localizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation (By similarity). Hepatocytes, kidney mesenchymal cells, intestinal ileum, colon epithelia and embryonic brain telencephalon neurons. In the embryo, expressed in the liver at 9 dpc, in the skin and transiently in the telencephalon at 12 dpc, and in the kidney, small intestine and cerebellum at 15 dpc. Down-regulated following a high-cholesterol diet. The C-terminal domain (CRD) is essential for the LDLR-binding and degrading activities. The catalytic domain is responsible for mediating its self- association. Cleavage by furin and PCSK5 generates a truncated inactive protein that is unable to induce LDLR degradation. Undergoes autocatalytic cleavage in the endoplasmic reticulum to release the propeptide from the N-terminus and the cleavage of the propeptide is strictly required for its maturation and activation. The cleaved propeptide however remains associated with the catalytic domain through non-covalent interactions, preventing potential substrates from accessing its active site. As a result, it is secreted from cells as a propeptide-containing, enzymatically inactive protein (By similarity). Phosphorylation protects the propeptide against proteolysis. Belongs to the peptidase S8 family. Sequence=AAP31672.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE28934.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAC60362.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; kidney development liver development negative regulation of receptor recycling positive regulation of receptor internalization serine-type endopeptidase activity extracellular region extracellular space cytoplasm lysosome endosome early endosome late endosome endoplasmic reticulum endoplasmic reticulum lumen rough endoplasmic reticulum Golgi apparatus plasma membrane proteolysis lipid metabolic process triglyceride metabolic process phospholipid metabolic process apoptotic process lysosomal transport steroid metabolic process cholesterol metabolic process peptidase activity serine-type peptidase activity cellular response to starvation cell surface regulation of receptor activity negative regulation of low-density lipoprotein particle clearance protein processing protein autoprocessing hydrolase activity sodium channel inhibitor activity neurogenesis ER to Golgi transport vesicle low-density lipoprotein particle binding neuron differentiation receptor inhibitor activity low-density lipoprotein receptor particle metabolic process low-density lipoprotein particle receptor catabolic process regulation of low-density lipoprotein particle receptor catabolic process positive regulation of low-density lipoprotein particle receptor catabolic process cellular response to insulin stimulus apolipoprotein binding very-low-density lipoprotein particle binding apolipoprotein receptor binding lipoprotein metabolic process cholesterol homeostasis regulation of neuron apoptotic process positive regulation of neuron apoptotic process protein self-association perinuclear region of cytoplasm low-density lipoprotein particle receptor binding very-low-density lipoprotein particle receptor binding negative regulation of low-density lipoprotein particle receptor binding negative regulation of low-density lipoprotein receptor activity negative regulation of receptor-mediated endocytosis involved in cholesterol transport PCSK9-LDLR complex PCSK9-AnxA2 complex negative regulation of receptor activity negative regulation of sodium ion transmembrane transporter activity uc008tyi.1 uc008tyi.2 uc008tyi.3 uc008tyi.4 
ENSMUST00000049509.7 Vat1l ENSMUST00000049509.7 vesicle amine transport protein 1 like (from RefSeq NM_173016.4) ENSMUST00000049509.1 ENSMUST00000049509.2 ENSMUST00000049509.3 ENSMUST00000049509.4 ENSMUST00000049509.5 ENSMUST00000049509.6 Kiaa1576 NM_173016 Q6PGM9 Q80TB8 VAT1L_MOUSE uc009noa.1 uc009noa.2 uc009noa.3 Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. Sequence=BAC65809.1; Type=Erroneous initiation; Evidence=; zinc ion binding oxidoreductase activity oxidation-reduction process uc009noa.1 uc009noa.2 uc009noa.3 
ENSMUST00000049530.14 A4galt ENSMUST00000049530.14 alpha 1,4-galactosyltransferase, transcript variant 4 (from RefSeq NM_001416098.1) A4GAT_MOUSE A4galt ENSMUST00000049530.1 ENSMUST00000049530.10 ENSMUST00000049530.11 ENSMUST00000049530.12 ENSMUST00000049530.13 ENSMUST00000049530.2 ENSMUST00000049530.3 ENSMUST00000049530.4 ENSMUST00000049530.5 ENSMUST00000049530.6 ENSMUST00000049530.7 ENSMUST00000049530.8 ENSMUST00000049530.9 NM_001416098 Q67BJ4 uc007xae.1 uc007xae.2 uc007xae.3 Catalyzes the transfer of galactose from UDP-alpha-D- galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer. Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes. Reaction=a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP- alpha-D-galactose = a globoside Gb3Cer (d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:11924, ChEBI:CHEBI:15378, ChEBI:CHEBI:17950, ChEBI:CHEBI:18313, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914; EC=2.4.1.228; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11925; Evidence=; Reaction=beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose = alpha-D-Gal- (1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP; Xref=Rhea:RHEA:60044, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:143593, ChEBI:CHEBI:143594; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60045; Evidence=; Glycolipid biosynthesis. Golgi apparatus membrane ; Single- pass type II membrane protein The conserved DXD motif is involved in enzyme activity. Belongs to the glycosyltransferase 32 family. Name=Functional Glycomics Gateway - GTase; Note=a4GalT; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_453"; Golgi membrane globoside biosynthetic process Golgi apparatus lipid metabolic process plasma membrane organization galactosyltransferase activity toxic substance binding membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups lactosylceramide 4-alpha-galactosyltransferase activity uc007xae.1 uc007xae.2 uc007xae.3 
ENSMUST00000049545.7 Adra2c ENSMUST00000049545.7 adrenergic receptor, alpha 2c (from RefSeq NM_007418.3) ADA2C_MOUSE ENSMUST00000049545.1 ENSMUST00000049545.2 ENSMUST00000049545.3 ENSMUST00000049545.4 ENSMUST00000049545.5 ENSMUST00000049545.6 NM_007418 Q01337 uc009vdd.1 uc009vdd.2 uc009vdd.3 Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily. G-protein coupled receptor activity adrenergic receptor activity alpha2-adrenergic receptor activity cytoplasm plasma membrane integral component of plasma membrane regulation of smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway female pregnancy membrane integral component of membrane regulation of vasoconstriction platelet activation axon alpha-2A adrenergic receptor binding activation of protein kinase B activity receptor transactivation identical protein binding protein homodimerization activity neuronal cell body positive regulation of MAPK cascade axon terminus positive regulation of neuron differentiation positive regulation of vasoconstriction protein heterodimerization activity epinephrine binding regulation of sensory perception of pain negative regulation of uterine smooth muscle contraction adrenergic receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway glutamatergic synapse integral component of postsynaptic membrane integral component of postsynaptic density membrane uc009vdd.1 uc009vdd.2 uc009vdd.3 
ENSMUST00000049575.8 Cltb ENSMUST00000049575.8 clathrin light chain B, transcript variant 1 (from RefSeq NM_001347512.1) CLCB_MOUSE ENSMUST00000049575.1 ENSMUST00000049575.2 ENSMUST00000049575.3 ENSMUST00000049575.4 ENSMUST00000049575.5 ENSMUST00000049575.6 ENSMUST00000049575.7 NM_001347512 Q6IRU5 Q8BR04 Q8CDX9 Q9CV35 uc007qon.1 uc007qon.2 uc007qon.3 Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts (via N-terminus) with HIP1. Interacts with HIP1R. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6IRU5-1; Sequence=Displayed; Name=2; IsoId=Q6IRU5-2; Sequence=VSP_013382; Name=3; IsoId=Q6IRU5-3; Sequence=VSP_013383; Belongs to the clathrin light chain family. structural molecule activity trans-Golgi network cytosol plasma membrane clathrin-coated pit intracellular protein transport membrane vesicle-mediated transport clathrin coat clathrin vesicle coat clathrin coat of trans-Golgi network vesicle clathrin coat of coated pit cytoplasmic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle clathrin heavy chain binding peptide binding intracellular membrane-bounded organelle clathrin coat assembly ciliary membrane clathrin-dependent endocytosis presynaptic endocytic zone membrane postsynaptic endocytic zone cytoplasmic component uc007qon.1 uc007qon.2 uc007qon.3 
ENSMUST00000049577.3 Adam26a ENSMUST00000049577.3 ADAM metallopeptidase domain 26A (from RefSeq NM_010085.3) AD26A_MOUSE Adam26 Adam26a ENSMUST00000049577.1 ENSMUST00000049577.2 G3X9D0 NM_010085 Q9R158 uc009lof.1 uc009lof.2 uc009lof.3 uc009lof.4 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during the late stages of spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. This gene is located adjacent to two other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]. ##Evidence-Data-START## Transcript exon combination :: AF167404.1, AK029756.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Membrane; Single-pass type I membrane protein. Expressed in sperm (at protein level) (PubMed:20945367). Expressed specifically in testis (PubMed:10395895). Adult expression levels are reached by day 25 after birth. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. metalloendopeptidase activity integrin binding proteolysis multicellular organism development spermatogenesis peptidase activity metallopeptidase activity external side of plasma membrane membrane integral component of membrane hydrolase activity cell differentiation metal ion binding sperm head plasma membrane uc009lof.1 uc009lof.2 uc009lof.3 uc009lof.4 
ENSMUST00000049583.8 Zbtb40 ENSMUST00000049583.8 zinc finger and BTB domain containing 40 (from RefSeq NM_198248.1) ENSMUST00000049583.1 ENSMUST00000049583.2 ENSMUST00000049583.3 ENSMUST00000049583.4 ENSMUST00000049583.5 ENSMUST00000049583.6 ENSMUST00000049583.7 NM_198248 Q6PCS8 Q6PCS8_MOUSE Zbtb40 uc008vit.1 uc008vit.2 molecular_function nucleic acid binding nucleus cellular response to DNA damage stimulus uc008vit.1 uc008vit.2 
ENSMUST00000049614.13 Trem6l ENSMUST00000049614.13 RIKEN cDNA B430306N03 gene, transcript variant 1 (from RefSeq NM_177083.5) B430306N03Rik Crkr ENSMUST00000049614.1 ENSMUST00000049614.10 ENSMUST00000049614.11 ENSMUST00000049614.12 ENSMUST00000049614.2 ENSMUST00000049614.3 ENSMUST00000049614.4 ENSMUST00000049614.5 ENSMUST00000049614.6 ENSMUST00000049614.7 ENSMUST00000049614.8 ENSMUST00000049614.9 NM_177083 Q6QX36 Q6QX36_MOUSE Treml6 treml6 uc008cxi.1 uc008cxi.2 uc008cxi.3 cell surface membrane integral component of membrane signaling receptor activity regulation of innate immune response uc008cxi.1 uc008cxi.2 uc008cxi.3 
ENSMUST00000049620.6 Or14j8 ENSMUST00000049620.6 olfactory receptor family 14 subfamily J member 8 (from RefSeq NM_001011829.1) ENSMUST00000049620.1 ENSMUST00000049620.2 ENSMUST00000049620.3 ENSMUST00000049620.4 ENSMUST00000049620.5 NM_001011829 Olfr761 Or14j8 Q7TRJ0 Q7TRJ0_MOUSE uc008cnu.1 uc008cnu.2 uc008cnu.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008cnu.1 uc008cnu.2 uc008cnu.3 
ENSMUST00000049621.7 Hes5 ENSMUST00000049621.7 hes family bHLH transcription factor 5, transcript variant 1 (from RefSeq NM_010419.4) ENSMUST00000049621.1 ENSMUST00000049621.2 ENSMUST00000049621.3 ENSMUST00000049621.4 ENSMUST00000049621.5 ENSMUST00000049621.6 Hes5 NM_010419 Q499J8 Q499J8_MOUSE uc008wck.1 uc008wck.2 Nucleus negative regulation of transcription from RNA polymerase II promoter DNA binding chromatin binding double-stranded DNA binding nucleus regulation of transcription, DNA-templated Notch signaling pathway positive regulation of cell proliferation forebrain radial glial cell differentiation neuron differentiation negative regulation of transcription, DNA-templated protein dimerization activity positive regulation of smooth muscle cell proliferation cartilage development neuronal stem cell population maintenance negative regulation of stem cell differentiation negative regulation of pro-B cell differentiation negative regulation of forebrain neuron differentiation uc008wck.1 uc008wck.2 
ENSMUST00000049624.3 Or5b12b ENSMUST00000049624.3 olfactory receptor family 5 subfamily B member 12B (from RefSeq NM_146699.1) ENSMUST00000049624.1 ENSMUST00000049624.2 NM_146699 Olfr1445 Or5b12b Q8VFW9 Q8VFW9_MOUSE uc008gus.1 uc008gus.2 uc008gus.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC138186.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gus.1 uc008gus.2 uc008gus.3 
ENSMUST00000049628.16 Atp5me ENSMUST00000049628.16 ATP synthase membrane subunit e, transcript variant 1 (from RefSeq NM_007507.3) ATP5I_MOUSE Atp5i Atp5k Atp5me ENSMUST00000049628.1 ENSMUST00000049628.10 ENSMUST00000049628.11 ENSMUST00000049628.12 ENSMUST00000049628.13 ENSMUST00000049628.14 ENSMUST00000049628.15 ENSMUST00000049628.2 ENSMUST00000049628.3 ENSMUST00000049628.4 ENSMUST00000049628.5 ENSMUST00000049628.6 ENSMUST00000049628.7 ENSMUST00000049628.8 ENSMUST00000049628.9 Lfm-1 Lfm1 NM_007507 P70342 Q06185 uc008yoa.1 uc008yoa.2 uc008yoa.3 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). Mitochondrion. Mitochondrion inner membrane. Mammary gland, liver, kidney, heart, spleen, brain and lung. Belongs to the ATPase e subunit family. mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) mitochondrion mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex ATP biosynthetic process ion transport hydrogen ion transmembrane transporter activity ATP synthesis coupled proton transport membrane ATPase activity macromolecular complex binding proton-transporting ATP synthase complex, coupling factor F(o) ATP metabolic process uc008yoa.1 uc008yoa.2 uc008yoa.3 
ENSMUST00000049630.13 Cox19 ENSMUST00000049630.13 cytochrome c oxidase assembly protein 19 (from RefSeq NM_197980.1) COX19_MOUSE ENSMUST00000049630.1 ENSMUST00000049630.10 ENSMUST00000049630.11 ENSMUST00000049630.12 ENSMUST00000049630.2 ENSMUST00000049630.3 ENSMUST00000049630.4 ENSMUST00000049630.5 ENSMUST00000049630.6 ENSMUST00000049630.7 ENSMUST00000049630.8 ENSMUST00000049630.9 NM_197980 Q8K0C8 uc009agj.1 uc009agj.2 uc009agj.3 Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. May be required for the assembly of mitochondrial cytochrome c oxidase. Interacts with CHCHD4/MIA40 forming transient intermolecular disulfide bridges. Cytoplasm, cytosol Mitochondrion intermembrane space Mitochondrion Note=Partitions between mitochondria and the cytosol in a copper-dependent manner. Enriched in the cytosol when intracellular copper concentrations are elevated. Belongs to the COX19 family. molecular_function cytoplasm mitochondrion mitochondrial intermembrane space cytosol cellular copper ion homeostasis mitochondrial respiratory chain complex IV assembly uc009agj.1 uc009agj.2 uc009agj.3 
ENSMUST00000049642.7 Fahd1 ENSMUST00000049642.7 fumarylacetoacetate hydrolase domain containing 1 (from RefSeq NM_023480.4) ENSMUST00000049642.1 ENSMUST00000049642.2 ENSMUST00000049642.3 ENSMUST00000049642.4 ENSMUST00000049642.5 ENSMUST00000049642.6 FAHD1_MOUSE MNCb-4134 NM_023480 Q3U020 Q3UQY4 Q8BLJ7 Q8R0F8 Q9JJB2 uc008ayl.1 uc008ayl.2 uc008ayl.3 uc008ayl.4 Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (By similarity). Also has oxaloacetate decarboxylase activity (PubMed:25575590). Reaction=a 3-acylpyruvate + H2O = a carboxylate + H(+) + pyruvate; Xref=Rhea:RHEA:19009, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:57278; EC=3.7.1.5; Evidence=; Reaction=H(+) + oxaloacetate = CO2 + pyruvate; Xref=Rhea:RHEA:15641, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526; EC=4.1.1.112; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Homodimer. Mitochondrion Cytoplasm, cytosol Ubiquitous with higher expression in the liver and the kidney (at protein level). No visible phenotype. Elevated oxaloacetate levels. Belongs to the FAH family. Sequence=BAC32142.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; catalytic activity nucleoplasm cytoplasm mitochondrion mitochondrial inner membrane cytosol oxaloacetate decarboxylase activity hydrolase activity lyase activity acetylpyruvate hydrolase activity fumarylpyruvate hydrolase activity metal ion binding acylpyruvate hydrolase activity uc008ayl.1 uc008ayl.2 uc008ayl.3 uc008ayl.4 
ENSMUST00000049644.9 Dppa3 ENSMUST00000049644.9 developmental pluripotency-associated 3 (from RefSeq NM_139218.1) Cap1p Crg1 DPPA3_MOUSE ENSMUST00000049644.1 ENSMUST00000049644.2 ENSMUST00000049644.3 ENSMUST00000049644.4 ENSMUST00000049644.5 ENSMUST00000049644.6 ENSMUST00000049644.7 ENSMUST00000049644.8 F6S6F5 NM_139218 Pgc7 Q8QZY3 uc009dpn.1 uc009dpn.2 uc009dpn.3 Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3- mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis. Nucleus toplasm Note=Localized in the cytoplasm at the primary oocyte stage and in oocytes within mono-laminar follicles. Expressed in the nucleus and cytoplasm of oocytes in bi-laminar and Graafian follicles and during the 2-cell and morula stages. In 3.5 dpc blastocysts localization is mainly nuclear. Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker. Expressed in the immature oocytes and in newborn ovaries. Subsequently detected in maturing oocytes and in preimplantation embryos. Expressed in pluripotent embryonic but not in differentiated somatic cells. Expressed in blastocysts, epiblasts, primordial germ cells, embryonic gonads and primitive spermatogonia. No expression is detected in adult testes. Detected at 3.5 dpc (at protein level). Activated during the process of germ cell specification at 7 dpc.25, specifically in the founder population of lineage-restricted primordial germ cells (PGCs). Thereafter, expressed in the germ line until about 15.5 dpc in male and 13.5 dpc in female gonads. Expressed during blastocyst, morula and 4-cell embryo stages. Mediates binding to H3K9me2 via N-terminal region, while ability to exclude TET3 from the maternal pronucleus requires the C- terminal part. Null mutation result in apparently normal offspring. No effect on early gonadal PGCs or gross abnormalities in the development of gametes. However, females display severely reduced fertility despite ovulation of normal numbers of oocytes. Null mutation resulted in preimplantation development failure. Embryos rarely reached the blastocyst stage. female pronucleus male pronucleus protein binding nucleus cytoplasm chromatin organization multicellular organism development methylated histone binding embryonic cleavage protection of DNA demethylation of female pronucleus negative regulation of DNA demethylation regulation of genetic imprinting uc009dpn.1 uc009dpn.2 uc009dpn.3 
ENSMUST00000049648.9 Kbtbd3 ENSMUST00000049648.9 kelch repeat and BTB (POZ) domain containing 3, transcript variant 2 (from RefSeq NM_001164574.1) Bklhd3 ENSMUST00000049648.1 ENSMUST00000049648.2 ENSMUST00000049648.3 ENSMUST00000049648.4 ENSMUST00000049648.5 ENSMUST00000049648.6 ENSMUST00000049648.7 ENSMUST00000049648.8 KBTB3_MOUSE Kbtbd3 NM_001164574 Q8BHI4 Q8BNJ8 uc009obl.1 uc009obl.2 uc009obl.3 uc009obl.4 uc009obl.1 uc009obl.2 uc009obl.3 uc009obl.4 
ENSMUST00000049655.3 Tmem215 ENSMUST00000049655.3 transmembrane protein 215, transcript variant 1 (from RefSeq NM_177175.4) B7ZN35 B7ZN35_MOUSE ENSMUST00000049655.1 ENSMUST00000049655.2 NM_177175 TMEM215 Tmem215 uc008shm.1 uc008shm.2 uc008shm.3 membrane integral component of membrane uc008shm.1 uc008shm.2 uc008shm.3 
ENSMUST00000049658.14 Pitpnm1 ENSMUST00000049658.14 phosphatidylinositol transfer protein, membrane-associated 1, transcript variant 4 (from RefSeq NR_177187.1) Dres9 ENSMUST00000049658.1 ENSMUST00000049658.10 ENSMUST00000049658.11 ENSMUST00000049658.12 ENSMUST00000049658.13 ENSMUST00000049658.2 ENSMUST00000049658.3 ENSMUST00000049658.4 ENSMUST00000049658.5 ENSMUST00000049658.6 ENSMUST00000049658.7 ENSMUST00000049658.8 ENSMUST00000049658.9 Mpt1 NR_177187 Nir2 O35954 PITM1_MOUSE Pitpnm uc008fyn.1 uc008fyn.2 uc008fyn.3 uc008fyn.4 Catalyzes the transfer of phosphatidylinositol (PI) between membranes (By similarity). Binds PI (PubMed:10400687). Also binds phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (By similarity). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (By similarity). Necessary for normal completion of cytokinesis (By similarity). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (By similarity). Required for protein export from the endoplasmic reticulum and the Golgi (By similarity). Binds calcium ions (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out); Xref=Rhea:RHEA:38691, ChEBI:CHEBI:57880; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38692; Evidence=; Interacts with PTK2B via its C-terminus. Interacts with RHOA. Has higher affinity for the inactive, GDP-bound form of RHOA. The CDK1- phosphorylated form interacts with PLK1. Interacts with VAPB and PIK4CA (By similarity). Cytoplasm Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein Endoplasmic reticulum membrane ; Peripheral membrane protein Lipid droplet Cleavage furrow Midbody Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets. Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis. Detected at high levels in brain, and at lower levels in lung, kidney, spleen and liver (at protein level). Ubiquitous. Highly expressed in embryonic retina and the central nervous system. Detected at low levels during fetal development up to day 15. Highly expressed at day 17. Phosphorylated on multiple sites by CDK1 at the onset of mitosis. Phosphorylation facilitates dissociation from the Golgi complex and is required for interaction with PLK1 (By similarity). Phosphorylated on threonine residues upon treatment with oleic acid. Phosphorylated on tyrosine residues by PTK2B. Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. calcium ion binding phospholipid binding phospholipid transporter activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus lipid particle microtubule organizing center cytosol phosphatidylcholine transporter activity phosphatidylinositol transporter activity protein transport phospholipid transport membrane midbody receptor tyrosine kinase binding phosphatidylcholine binding cleavage furrow Golgi cisterna membrane phosphatidylinositol binding cytoplasmic ribonucleoprotein granule cell body metal ion binding phosphatidic acid binding uc008fyn.1 uc008fyn.2 uc008fyn.3 uc008fyn.4 
ENSMUST00000049676.3 Trpv3 ENSMUST00000049676.3 transient receptor potential cation channel, subfamily V, member 3, transcript variant 3 (from RefSeq NR_163834.1) ENSMUST00000049676.1 ENSMUST00000049676.2 NR_163834 Q5SV08 Q8K424 TRPV3_MOUSE uc007kaj.1 uc007kaj.2 uc007kaj.3 Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity). May form a heteromeric channel with TRPV1. Interacts with TRPV1 (By similarity). Q8K424; P00533: EGFR; Xeno; NbExp=2; IntAct=EBI-2650739, EBI-297353; Membrane ; Multi-pass membrane protein Expressed in keratinocytes and hair follicles. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily. ion channel activity cation channel activity calcium channel activity protein binding integral component of plasma membrane ion transport calcium ion transport response to temperature stimulus response to heat membrane integral component of membrane negative regulation of hair cycle receptor complex transmembrane transport calcium ion transmembrane transport positive regulation of calcium ion import uc007kaj.1 uc007kaj.2 uc007kaj.3 
ENSMUST00000049681.14 Itgbl1 ENSMUST00000049681.14 integrin, beta-like 1 (from RefSeq NM_145467.2) ENSMUST00000049681.1 ENSMUST00000049681.10 ENSMUST00000049681.11 ENSMUST00000049681.12 ENSMUST00000049681.13 ENSMUST00000049681.2 ENSMUST00000049681.3 ENSMUST00000049681.4 ENSMUST00000049681.5 ENSMUST00000049681.6 ENSMUST00000049681.7 ENSMUST00000049681.8 ENSMUST00000049681.9 ITGBL_MOUSE NM_145467 Q8BKJ4 Q8BMS0 Q8VDV0 uc007vbu.1 uc007vbu.2 uc007vbu.3 uc007vbu.4 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VDV0-1; Sequence=Displayed; Name=2; IsoId=Q8VDV0-2; Sequence=VSP_032005, VSP_032006; Contains ten tandem EGF-like repeats strikingly similar to those found in the cysteine rich 'stalk-like' structure of integrin beta-subunits. integrin binding extracellular region extracellular space cell-matrix adhesion integrin-mediated signaling pathway cell migration cell adhesion mediated by integrin uc007vbu.1 uc007vbu.2 uc007vbu.3 uc007vbu.4 
ENSMUST00000049697.5 Cldn8 ENSMUST00000049697.5 claudin 8 (from RefSeq NM_018778.3) CLD8_MOUSE Cldn8 ENSMUST00000049697.1 ENSMUST00000049697.2 ENSMUST00000049697.3 ENSMUST00000049697.4 NM_018778 Q9Z260 uc007zuz.1 uc007zuz.2 uc007zuz.3 uc007zuz.4 This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a paracellular cation barrier. [provided by RefSeq, Aug 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK133810.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Tight-junction protein required for paracellular chloride transport in the kidney (PubMed:20921420, PubMed:25831548). Mediates recruitment of CLDN4 to tight junction in the kidney (PubMed:20921420, PubMed:25831548). Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (PubMed:10601346). Interacts with CLDN4 (PubMed:20921420). Interacts with KLHL3 (PubMed:25831548). Cell junction, tight junction ll membrane ; Multi-pass membrane protein Expressed primarily in lung and kidney (PubMed:9892664). Present in both cortical and medullar collecting ducts (at protein level) (PubMed:20921420). Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation. Conditional knockout mice lacking Cldn8 in the collecting duct of kidney show hypotension, hypokalemia, and metabolic alkalosis (PubMed:25831548). Belongs to the claudin family. structural molecule activity protein binding plasma membrane bicellular tight junction membrane integral component of membrane basolateral plasma membrane apicolateral plasma membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding uc007zuz.1 uc007zuz.2 uc007zuz.3 uc007zuz.4 
ENSMUST00000049699.9 Pskh1 ENSMUST00000049699.9 protein serine kinase H1 (from RefSeq NM_173432.2) ENSMUST00000049699.1 ENSMUST00000049699.2 ENSMUST00000049699.3 ENSMUST00000049699.4 ENSMUST00000049699.5 ENSMUST00000049699.6 ENSMUST00000049699.7 ENSMUST00000049699.8 KPSH1_MOUSE NM_173432 Q3U3V3 Q91YA2 uc009nen.1 uc009nen.2 uc009nen.3 May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Activity depends on Ca(2+) concentration. Homodimer. Golgi apparatus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus speckle Endoplasmic reticulum membrane ; Lipid-anchor Cell membrane ; Lipid-anchor Cytoplasm Note=Localized in the brefeldin A- sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes (By similarity). Autophosphorylated on serine residues. Myristoylated. Required for membrane association. Prerequisite for palmitoylation to occur (By similarity). Palmitoylated. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus microtubule organizing center cytoskeleton plasma membrane protein phosphorylation determination of left/right symmetry heart development membrane kinase activity phosphorylation nuclear speck transferase activity uc009nen.1 uc009nen.2 uc009nen.3 
ENSMUST00000049705.8 Zfp457 ENSMUST00000049705.8 zinc finger protein 457 (from RefSeq NM_001003666.2) ENSMUST00000049705.1 ENSMUST00000049705.2 ENSMUST00000049705.3 ENSMUST00000049705.4 ENSMUST00000049705.5 ENSMUST00000049705.6 ENSMUST00000049705.7 L7N1X4 L7N1X4_MOUSE NM_001003666 Zfp457 uc007ran.1 uc007ran.2 uc007ran.3 nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated membrane integral component of membrane negative regulation of transcription, DNA-templated metal ion binding negative regulation of transposon integration uc007ran.1 uc007ran.2 uc007ran.3 
ENSMUST00000049706.11 Fcer1a ENSMUST00000049706.11 Fc receptor, IgE, high affinity I, alpha polypeptide (from RefSeq NM_010184.2) E9QLR4 ENSMUST00000049706.1 ENSMUST00000049706.10 ENSMUST00000049706.2 ENSMUST00000049706.3 ENSMUST00000049706.4 ENSMUST00000049706.5 ENSMUST00000049706.6 ENSMUST00000049706.7 ENSMUST00000049706.8 ENSMUST00000049706.9 FCERA_MOUSE Fce1a NM_010184 P20489 uc007dre.1 uc007dre.2 uc007dre.3 uc007dre.4 High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Interacts with IGHE (via CH3 region). Cell membrane ; Single-pass type I membrane protein Expressed in bone marrow mast cells, as well as in the pineal gland at night. Exhibits night/day variations with an increased expression at night in the pineal gland. activation of MAPK activity positive regulation of type I hypersensitivity serotonin secretion protein binding plasma membrane integral component of plasma membrane signal transduction cell surface receptor signaling pathway activation of JUN kinase activity external side of plasma membrane cell surface membrane integral component of membrane leukotriene biosynthetic process IgE receptor activity IgE binding Fc-epsilon receptor signaling pathway positive regulation of mast cell degranulation membrane raft positive regulation of interleukin-3 biosynthetic process positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of calcium-mediated signaling uc007dre.1 uc007dre.2 uc007dre.3 uc007dre.4 
ENSMUST00000049714.15 Synrg ENSMUST00000049714.15 synergin, gamma, transcript variant 4 (from RefSeq NM_001405115.1) Ap1gbp1 ENSMUST00000049714.1 ENSMUST00000049714.10 ENSMUST00000049714.11 ENSMUST00000049714.12 ENSMUST00000049714.13 ENSMUST00000049714.14 ENSMUST00000049714.2 ENSMUST00000049714.3 ENSMUST00000049714.4 ENSMUST00000049714.5 ENSMUST00000049714.6 ENSMUST00000049714.7 ENSMUST00000049714.8 ENSMUST00000049714.9 NM_001405115 Q5SV84 Q5SV85 Q6PHT6 SYNRG_MOUSE Syng uc288axy.1 uc288axy.2 Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (By similarity). May act by linking the adapter protein complex AP-1 to other proteins (By similarity). Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP- 1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity). Self-associates (By similarity). Interacts with GGA1 (via GAE domain) (By similarity). Interacts with GGA2 and GGA3 (By similarity). Interacts with AP1G1 (via GAE domain), a subunit of adapter protein complex AP-1 (By similarity). Interacts with AP1G2 (via GAE domain) a subunit of adapter protein complex AP-1 (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, at least composed of AFTPH/aftiphilin, HEATR5B/p200a and SYNRG/gamma-synergin, which plays a role in the AP1G1/AP-1-mediated trafficking of transferrin from early to recycling endosomes (By similarity). Within the complex interacts with AFTPH/aftiphilin and HEATR5B/p200a; the interactions are direct (By similarity). Interacts (via EH domain) with SCAMP1 (By similarity). Cytoplasm, cytosol Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Cytoplasm, perinuclear region Cytoplasmic vesicle, clathrin-coated vesicle Note=Localization at clathrin- coated vesicles depends on AFTPH/aftiphilin (By similarity). Associates with membranes via the adapter protein complex AP-1 (By similarity). Colocalizes with AP1G1 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SV85-1; Sequence=Displayed; Name=2; IsoId=Q5SV85-2; Sequence=VSP_013251, VSP_013252, VSP_013253, VSP_013254; The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2. Sequence=CAI25511.1; Type=Erroneous gene model prediction; Evidence=; molecular_function cytoplasm Golgi apparatus cytosol endocytosis biological_process protein transport membrane clathrin coat of trans-Golgi network vesicle uc288axy.1 uc288axy.2 
ENSMUST00000049721.9 Fam3b ENSMUST00000049721.9 FAM3 metabolism regulating signaling molecule B (from RefSeq NM_020622.3) ENSMUST00000049721.1 ENSMUST00000049721.2 ENSMUST00000049721.3 ENSMUST00000049721.4 ENSMUST00000049721.5 ENSMUST00000049721.6 ENSMUST00000049721.7 ENSMUST00000049721.8 FAM3B_MOUSE NM_020622 O88417 ORF9 Q9D309 uc008adj.1 uc008adj.2 uc008adj.3 Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Secreted Note=Present in insulin secretory granules and likely cosecreted with insulin. Expressed at high levels in the pancreas and, to a lesser extent, in small intestine and prostate. Also detected in stomach, testis and fetal liver. In the pancreas, localized in the islets of Langerhans; in the testis, found primarily in the round spermatids; in the CNS, found in the Purkinje cell layer of the cerebellum and in nerve cell bodies of numerous brainstem nuclei. By glucose. O-glycosylated. It is unclear whether the N-terminus residue of the mature protein is Glu-30 or Ser-46. Belongs to the FAM3 family. cytokine activity extracellular region extracellular space nuclear envelope lumen apoptotic process signal transduction insulin secretion glucose homeostasis uc008adj.1 uc008adj.2 uc008adj.3 
ENSMUST00000049732.11 Uqcc5 ENSMUST00000049732.11 ubiquinol-cytochrome c reductase complex assembly factor 5, transcript variant 2 (from RefSeq NM_001308091.2) ENSMUST00000049732.1 ENSMUST00000049732.10 ENSMUST00000049732.2 ENSMUST00000049732.3 ENSMUST00000049732.4 ENSMUST00000049732.5 ENSMUST00000049732.6 ENSMUST00000049732.7 ENSMUST00000049732.8 ENSMUST00000049732.9 NM_001308091 Q8BZ92 Q8C1P1 Q8C1Q6 Smim4 UQCC5_MOUSE Uqcc5 uc007swr.1 uc007swr.2 uc007swr.3 uc007swr.4 Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:35977508). Mediates early complex III biogenesis (PubMed:35977508). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (PubMed:35977508). Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity). Associates with the mitochondrial ribosome. Interacts with UQCC6. Interacts with MT-CYB; interacts with newly synthesizes MT-CYB (By similarity). Forms a complex, named COMB/coordinator of mitochondrial CYTB biogenesis, composed of UQCC1, UQCC2, UQCC4, UQCC5 and UQCC6; stabilizes nascent cytochrome b/MT-CYB and promotes its membrane insertion (PubMed:35977508). Mitochondrion inner membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C1Q6-1; Sequence=Displayed; Name=2; IsoId=Q8C1Q6-2; Sequence=VSP_035265; Name=3; IsoId=Q8C1Q6-3; Sequence=VSP_035266, VSP_035267; Belongs to the UQCC5 family. Sequence=BAC25173.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC25215.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function mitochondrion biological_process membrane integral component of membrane uc007swr.1 uc007swr.2 uc007swr.3 uc007swr.4 
ENSMUST00000049740.3 Zbtb33 ENSMUST00000049740.3 zinc finger and BTB domain containing 33, transcript variant 1 (from RefSeq NM_020256.2) ENSMUST00000049740.1 ENSMUST00000049740.2 KAISO_MOUSE Kaiso NM_020256 Q8BN78 Q8C226 Q9WTZ7 uc009szp.1 uc009szp.2 Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). May recruit the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. Contributes to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (By similarity). Interacts with NCOR1 (By similarity). Self-associates. Interacts with CTNND1, and this interaction inhibits binding to both methylated and non-methylated DNA. Interacts with CTNND2. Interacts with KPNA2/RCH1, which may mediate nuclear import of this protein. Interacts with CBFA2T3 (By similarity). Q8BN78; P30999: Ctnnd1; NbExp=3; IntAct=EBI-1216314, EBI-529924; Nucleus Expressed in brain, heart, kidney, liver, lung, neuromuscular junctions, skeletal muscle, spleen and testis. nucleic acid binding DNA binding protein binding nucleus nucleoplasm nucleolus cytosol plasma membrane transcription, DNA-templated methyl-CpG binding Wnt signaling pathway sequence-specific DNA binding negative regulation of transcription, DNA-templated metal ion binding uc009szp.1 uc009szp.2 
ENSMUST00000049744.4 Mplkip ENSMUST00000049744.4 M-phase specific PLK1 intereacting protein (from RefSeq NM_025479.6) ENSMUST00000049744.1 ENSMUST00000049744.2 ENSMUST00000049744.3 MPLKI_MOUSE NM_025479 Q9D011 Ttdn1 uc007poa.1 uc007poa.2 May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. Interacts with PLK1; phosphorylation-dependent. Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase. Phosphorylated during mitosis in the cell cycle probably by CDK1. molecular_function nucleus nucleoplasm cytoplasm Golgi apparatus centrosome microtubule organizing center cytoskeleton cell cycle midbody intracellular membrane-bounded organelle cell division uc007poa.1 uc007poa.2 
ENSMUST00000049768.4 Epx ENSMUST00000049768.4 eosinophil peroxidase (from RefSeq NM_007946.2) ENSMUST00000049768.1 ENSMUST00000049768.2 ENSMUST00000049768.3 Eper NM_007946 P49290 PERE_MOUSE Q5SW51 Q61798 uc007kuw.1 uc007kuw.2 uc007kuw.3 This gene encodes a member of the peroxidase superfamily of enzymes that is produced by eosinophils and plays a critical role in eliminating tissue-invasive parasites. The encoded preproprotein undergoes proteolytic processing to generate a heterodimeric enzyme that forms a predominant component of the intracellular granules of eosinophils. Mice lacking the encoded protein exhibit resistance to ulcerative colitis induced by dextran sulfate. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D78353.1, BC052881.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Reaction=2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O; Xref=Rhea:RHEA:56136, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:139520, ChEBI:CHEBI:139521; EC=1.11.1.7; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per heterodimer. Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer. ; Tetramer of two light chains and two heavy chains. Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils. Belongs to the peroxidase family. XPO subfamily. Sequence=AAB40403.1; Type=Erroneous initiation; Evidence=; defense response to nematode peroxidase activity extracellular space cytoplasm defense response response to oxidative stress oxidoreductase activity heme binding negative regulation of interleukin-10 production negative regulation of interleukin-5 production positive regulation of interleukin-4 production defense response to bacterium hydrogen peroxide catabolic process metal ion binding oxidation-reduction process eosinophil migration cellular oxidant detoxification uc007kuw.1 uc007kuw.2 uc007kuw.3 
ENSMUST00000049778.7 Zfp11 ENSMUST00000049778.7 zinc finger protein 11 (from RefSeq NM_172462.4) B2RTF0 ENSMUST00000049778.1 ENSMUST00000049778.2 ENSMUST00000049778.3 ENSMUST00000049778.4 ENSMUST00000049778.5 ENSMUST00000049778.6 Krox-6.1a Krox-6.1b NM_172462 P10751 P10752 P10753 Q505E4 Q6PDR5 Q8BSI2 Q8C3R5 ZFP11_MOUSE uc008zta.1 uc008zta.2 uc008zta.3 Nucleus Sequence=AAH58553.1; Type=Erroneous initiation; Evidence=; Sequence=BAC28063.1; Type=Frameshift; Evidence=; transcription regulatory region sequence-specific DNA binding nucleic acid binding DNA binding nucleus metal ion binding uc008zta.1 uc008zta.2 uc008zta.3 
ENSMUST00000049787.3 Lrrn4 ENSMUST00000049787.3 leucine rich repeat neuronal 4 (from RefSeq NM_177303.4) A2ANX0 ENSMUST00000049787.1 ENSMUST00000049787.2 LRRN4_MOUSE NM_177303 P59383 uc008mnn.1 uc008mnn.2 uc008mnn.3 May play an important role in hippocampus-dependent long- lasting memory. Membrane ; Single-pass type I membrane protein Mice are viable and fertile, but show impaired memory retention. Lrrn4-deficient mice are able to maintain memories for one day in hippocampus-dependent learning tasks, but are unable to retain memories for four days after learning. In contrast, in hippocampus-independent tasks Lrrn4-deficient mice normally retain memories for at least seven days. molecular_function integral component of plasma membrane long-term memory visual learning membrane integral component of membrane uc008mnn.1 uc008mnn.2 uc008mnn.3 
ENSMUST00000049789.3 Naip5 ENSMUST00000049789.3 NLR family, apoptosis inhibitory protein 5, transcript variant 1 (from RefSeq NM_010870.3) BIR1E_MOUSE Birc1e ENSMUST00000049789.1 ENSMUST00000049789.2 NM_010870 Naip-rs3 Naip5 O09121 O09122 P81703 Q8CGT2 Q9R016 Q9R029 uc288png.1 uc288png.2 Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria such as Legionella or Salmonella (PubMed:12526741, PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram- negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). May contribute to prevent motor-neuron apoptosis induced by a variety of signals (By similarity). Component of the NLRC4 inflammasome, at least composed of NLRC4, caspase-1 (CASP1) and some NAIP protein. Flagellin binding by NAIP5 triggers assembly of the inflammasome, a huge complex that contains a single NAIP5 chain and multiple copies of NLRC4 (PubMed:29182158). (Microbial infection) Interacts with S.typhimurium (Salmonella) flagellin. (Microbial infection) Interacts with L.pneumophila flagellin. Q9R016; Q3UP24: Nlrc4; NbExp=18; IntAct=EBI-15944130, EBI-16006652; Q9R016; Q48824: flaA; Xeno; NbExp=2; IntAct=EBI-15944130, EBI-15944232; Q9R016; P06179: fliC; Xeno; NbExp=9; IntAct=EBI-15944130, EBI-2011501; Detected in macrophages (at protein level). Part of the Lgn1 locus that determines susceptibility to the intracellular pathogen L.pneumophila. Susceptibility differs between inbred mouse strains. Strain C57BL/6J is not permissive, i.e. L.pneumophila cannot multiply in C57BL/6J macrophages, contrary to the situation in mouse strain A/J. Strain FVB/NJ macrophages display intermediate permissiveness for intracellular proliferation of L.pneumophila. nucleotide binding immune system process protein binding ATP binding cytoplasm apoptotic process inflammatory response detection of bacterium positive regulation of interleukin-1 beta production entry of bacterium into host cell defense response to bacterium neuron projection neuronal cell body cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process perikaryon innate immune response metal ion binding defense response to Gram-negative bacterium pyroptosis IPAF inflammasome complex uc288png.1 uc288png.2 
ENSMUST00000049790.14 Camta1 ENSMUST00000049790.14 calmodulin binding transcription activator 1, transcript variant 1 (from RefSeq NM_001081557.3) A2A891 A2A892 A2A896 A2A897 A2A898 B2KGR3 B2KGR4 CMTA1_MOUSE Camta1 ENSMUST00000049790.1 ENSMUST00000049790.10 ENSMUST00000049790.11 ENSMUST00000049790.12 ENSMUST00000049790.13 ENSMUST00000049790.2 ENSMUST00000049790.3 ENSMUST00000049790.4 ENSMUST00000049790.5 ENSMUST00000049790.6 ENSMUST00000049790.7 ENSMUST00000049790.8 ENSMUST00000049790.9 Kiaa0833 NM_001081557 Q80TQ8 uc008vyn.1 uc008vyn.2 uc008vyn.3 uc008vyn.4 Transcriptional activator. May interact with calmodulin. Nucleus toplasm Event=Alternative splicing; Named isoforms=5; Name=1 ; IsoId=A2A891-1; Sequence=Displayed; Name=2; IsoId=A2A891-2; Sequence=VSP_052990; Name=3; IsoId=A2A891-3; Sequence=VSP_052987, VSP_052988; Name=4; IsoId=A2A891-4; Sequence=VSP_052987, VSP_052988, VSP_052990, VSP_052991; Name=5; IsoId=A2A891-5; Sequence=VSP_052989, VSP_052990, VSP_052991; Belongs to the CAMTA family. Sequence=CAM24788.2; Type=Erroneous gene model prediction; Evidence=; RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding nucleus nucleolus cytoplasm cytosol positive regulation of protein dephosphorylation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter neuromuscular process controlling balance positive regulation of calcineurin-NFAT signaling cascade uc008vyn.1 uc008vyn.2 uc008vyn.3 uc008vyn.4 
ENSMUST00000049793.9 Duxbl1 ENSMUST00000049793.9 double homeobox B-like 1 (from RefSeq NM_183389.2) Duxbl Duxbl1 ENSMUST00000049793.1 ENSMUST00000049793.2 ENSMUST00000049793.3 ENSMUST00000049793.4 ENSMUST00000049793.5 ENSMUST00000049793.6 ENSMUST00000049793.7 ENSMUST00000049793.8 NM_183389 Q7TNE6 Q7TNE6_MOUSE uc007ssa.1 uc007ssa.2 uc007ssa.3 uc007ssa.4 uc007ssa.5 Nucleus molecular_function DNA binding nucleus biological_process regulation of T cell differentiation uc007ssa.1 uc007ssa.2 uc007ssa.3 uc007ssa.4 uc007ssa.5 
ENSMUST00000049811.8 Cep120 ENSMUST00000049811.8 centrosomal protein 120 (from RefSeq NM_178686.4) CE120_MOUSE Ccdc100 ENSMUST00000049811.1 ENSMUST00000049811.2 ENSMUST00000049811.3 ENSMUST00000049811.4 ENSMUST00000049811.5 ENSMUST00000049811.6 ENSMUST00000049811.7 NM_178686 Q7TSG1 Q80Y93 Q80ZQ2 Q8BG01 Q8C580 Q8C8B6 Q8CAF2 uc008exy.1 uc008exy.2 uc008exy.3 uc008exy.4 Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity). Interacts with TACC2, TACC3, CCDC52, TALPID3. Q7TSG1; E9PV87: Talpid3; NbExp=3; IntAct=EBI-2553947, EBI-11692182; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q7TSG1-1; Sequence=Displayed; Name=2; IsoId=Q7TSG1-2; Sequence=VSP_035130; Name=3; IsoId=Q7TSG1-3; Sequence=VSP_035127, VSP_035128; Name=4; IsoId=Q7TSG1-4; Sequence=VSP_035126, VSP_035129; Ubiquitous. Highly expressed in brain, lung and kidney and weakly expressed in heart, liver, small intestine and limb (at protein level). Expressed in brain. Expressed in embryonic brain from 10.5 to 17.5 dpc. Expressed in neocortical neural progenitors at the ventrical surface at 12.5 dpc (at protein level). Expressed in brain, heart, lung, liver, kidney, small intestine and limb at 16.5 dpc. Belongs to the CEP120 family. microtubule cytoskeleton organization protein binding cytoplasm centrosome centriole microtubule organizing center cytoskeleton centrosome cycle protein C-terminus binding cell proliferation positive regulation of centrosome duplication cerebral cortex development neurogenesis interkinetic nuclear migration astral microtubule organization regulation of protein localization regulation of microtubule-based process positive regulation of cilium assembly positive regulation of centriole elongation positive regulation of establishment of protein localization uc008exy.1 uc008exy.2 uc008exy.3 uc008exy.4 
ENSMUST00000049813.6 Yod1 ENSMUST00000049813.6 YOD1 deubiquitinase (from RefSeq NM_178691.5) B2RSW9 ENSMUST00000049813.1 ENSMUST00000049813.2 ENSMUST00000049813.3 ENSMUST00000049813.4 ENSMUST00000049813.5 NM_178691 OTU1_MOUSE Q8BPM9 Q8CB24 Q8CB27 uc007cmh.1 uc007cmh.2 uc007cmh.3 uc007cmh.4 uc007cmh.5 Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with VCP; the interaction is direct. Interacts with FAF2/UBXD8. Interacts with DERL1; however interaction is dependent on the UBAX-like region, suggesting that it may be indirect. Interacts with PLAA, UBXN6 and VCP; may form a complex involved in macroautophagy. Cytoplasm Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. The UBAX-like region mediates the interaction with VCP. The C2H2-type zinc finger mediates specificity for 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains but not for 'Lys- 11'-linked ubiquitin chains. Selectivity for 'Lys-11'-linked ubiquitin chains is provided by recognition of the sequence surrounding 'Lys-11' in ubiquitin. The S2 site region provides specificity for longer 'Lys- 11'-linked ubiquitin chains. Sequence=BAC29661.1; Type=Frameshift; Evidence=; Sequence=BAC35495.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; nucleic acid binding thiol-dependent ubiquitin-specific protease activity cytoplasm cytosol proteolysis response to unfolded protein peptidase activity cysteine-type peptidase activity macroautophagy protein deubiquitination hydrolase activity ER-associated ubiquitin-dependent protein catabolic process endoplasmic reticulum unfolded protein response ubiquitin protein ligase binding protein K29-linked deubiquitination protein K11-linked deubiquitination thiol-dependent ubiquitinyl hydrolase activity metal ion binding protein K63-linked deubiquitination protein K48-linked deubiquitination ubiquitinyl hydrolase activity negative regulation of retrograde protein transport, ER to cytosol protein K27-linked deubiquitination protein K33-linked deubiquitination Lys48-specific deubiquitinase activity uc007cmh.1 uc007cmh.2 uc007cmh.3 uc007cmh.4 uc007cmh.5 
ENSMUST00000049819.4 Vmn1r179 ENSMUST00000049819.4 vomeronasal 1 receptor 179 (from RefSeq NM_207545.1) ENSMUST00000049819.1 ENSMUST00000049819.2 ENSMUST00000049819.3 NM_207545 Q8R2B4 Q8R2B4_MOUSE V1rd17 Vmn1r179 uc009fom.1 uc009fom.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009fom.1 uc009fom.2 
ENSMUST00000049822.10 Them4 ENSMUST00000049822.10 thioesterase superfamily member 4 (from RefSeq NM_029431.2) A3KPD5 Ctmp ENSMUST00000049822.1 ENSMUST00000049822.2 ENSMUST00000049822.3 ENSMUST00000049822.4 ENSMUST00000049822.5 ENSMUST00000049822.6 ENSMUST00000049822.7 ENSMUST00000049822.8 ENSMUST00000049822.9 NM_029431 Q3UUI3 Q8BYS9 Q8R234 Q9D5Y3 THEM4_MOUSE uc008qfu.1 uc008qfu.2 uc008qfu.3 Has acyl-CoA thioesterase activity towards medium and long- chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (PubMed:19421406). Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence=; Reaction=H2O + octanoyl-CoA = CoA + H(+) + octanoate; Xref=Rhea:RHEA:30143, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30144; Evidence=; Reaction=decanoyl-CoA + H2O = CoA + decanoate + H(+); Xref=Rhea:RHEA:40059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40060; Evidence=; Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence=; Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40140; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)- eicosatetraenoate + CoA + H(+); Xref=Rhea:RHEA:40151, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40152; Evidence=; Homodimer and homotetramer (By similarity). Interacts with AKT1 in the cytosol (PubMed:11598301). (Microbial infection) Interacts with V-AKT from AKT8 murine leukemia virus. Cell membrane Cell projection, ruffle membrane Cytoplasm Mitochondrion Mitochondrion inner membrane ; Peripheral membrane protein Mitochondrion intermembrane space Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. Phosphorylated. No visible phenotype. Mice have abnormally elongated mitochondria, but mitochondrial function appears to be normal. Belongs to the THEM4/THEM5 thioesterase family. Sequence=AAI34397.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAB29572.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC29995.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; cytoplasm mitochondrion mitochondrial inner membrane mitochondrial intermembrane space cytosol plasma membrane lipid metabolic process fatty acid metabolic process apoptotic process membrane viral process palmitoyl-CoA hydrolase activity hydrolase activity ruffle membrane cell projection protein kinase B signaling regulation of mitochondrial membrane permeability involved in apoptotic process uc008qfu.1 uc008qfu.2 uc008qfu.3 
ENSMUST00000049849.12 Pfkfb3 ENSMUST00000049849.12 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, transcript variant 3 (from RefSeq NM_001177754.1) A2AUP5 A2AUP5_MOUSE A7UAK6 ENSMUST00000049849.1 ENSMUST00000049849.10 ENSMUST00000049849.11 ENSMUST00000049849.2 ENSMUST00000049849.3 ENSMUST00000049849.4 ENSMUST00000049849.5 ENSMUST00000049849.6 ENSMUST00000049849.7 ENSMUST00000049849.8 ENSMUST00000049849.9 NM_001177754 Pfkfb3 uc008iil.1 uc008iil.2 uc008iil.3 uc008iil.4 uc008iil.5 In the C-terminal section; belongs to the phosphoglycerate mutase family. catalytic activity 6-phosphofructo-2-kinase activity fructose-2,6-bisphosphate 2-phosphatase activity ATP binding nucleoplasm cytosol fructose metabolic process fructose 2,6-bisphosphate metabolic process kinase activity phosphorylation dephosphorylation transferase activity hydrolase activity carbohydrate phosphorylation uc008iil.1 uc008iil.2 uc008iil.3 uc008iil.4 uc008iil.5 
ENSMUST00000049852.10 Prok1 ENSMUST00000049852.10 prokineticin 1, transcript variant 1 (from RefSeq NM_001044382.2) ENSMUST00000049852.1 ENSMUST00000049852.2 ENSMUST00000049852.3 ENSMUST00000049852.4 ENSMUST00000049852.5 ENSMUST00000049852.6 ENSMUST00000049852.7 ENSMUST00000049852.8 ENSMUST00000049852.9 NM_001044382 PROK1_MOUSE Pk1 Prok1 Q0P609 Q14A28 Q8K457 uc008qwv.1 uc008qwv.2 uc008qwv.3 Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. Secreted Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q14A28-1; Sequence=Displayed; Name=2 ; IsoId=Q14A28-2; Sequence=VSP_053117; Highly expressed in liver and ovary and weakly expressed in testis and placenta. Expressed in mucosa and mesenchyme of embryonic gut during enteric nervous system development (at protein level). Predominantly expressed in kidney and liver. Also expressed in lung, ovary, placenta and testis. In fetal liver, is restricted to and highly expressed in hepatocytes. In adult kidney, expression is restricted to the endothelial tubule cells. In placenta, expressed throughout gestation. In placenta, at 7.5 dpc highly expressed in ectoplacental cone, endoderm and in giant cells, and at 9.5 dpc restricted mainly to the labyrinth layer (at protein level). In placenta, most highly expressed during early gestation (between 9.5 and 10.5 dpc). Belongs to the AVIT (prokineticin) family. activation of MAPK activity angiogenesis G-protein coupled receptor binding extracellular region signal transduction circadian rhythm growth factor activity positive regulation of cell proliferation regulation of angiogenesis positive regulation of cell division uc008qwv.1 uc008qwv.2 uc008qwv.3 
ENSMUST00000049863.12 Pofut1 ENSMUST00000049863.12 protein O-fucosyltransferase 1 (from RefSeq NM_080463.4) ENSMUST00000049863.1 ENSMUST00000049863.10 ENSMUST00000049863.11 ENSMUST00000049863.2 ENSMUST00000049863.3 ENSMUST00000049863.4 ENSMUST00000049863.5 ENSMUST00000049863.6 ENSMUST00000049863.7 ENSMUST00000049863.8 ENSMUST00000049863.9 NM_080463 OFUT1_MOUSE Q3V1R0 Q8C8R4 Q91ZW2 uc008nhm.1 uc008nhm.2 uc008nhm.3 uc008nhm.4 Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs). Reaction=GDP-beta-L-fucose + L-seryl-[protein] = 3-O-(alpha-L-fucosyl)- L-seryl-[protein] + GDP + H(+); Xref=Rhea:RHEA:63644, Rhea:RHEA- COMP:9863, Rhea:RHEA-COMP:17914, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:189632; EC=2.4.1.221; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63645; Evidence=; Reaction=GDP-beta-L-fucose + L-threonyl-[protein] = 3-O-(alpha-L- fucosyl)-L-threonyl-[protein] + GDP + H(+); Xref=Rhea:RHEA:70491, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:17915, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:189631; EC=2.4.1.221; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70492; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum Increased expression throughout embryo development. Ubiquitous expression at 9.5 dpc and 11.5 dpc with lower expression at 9.5 dpc. N-glycosylated. Early embryos of null mice are defective in somitogenesis. At 8.5 dpc, embryos are of normal size and appearance but somites adjacent to the presomitic mesoderm (PSM) are fused. In 8.25 dpc embryos, expression of NOTCH target genes such as HES5 and JAG1 as well as LFNG and UNCX4.1 is severely reduced in somites. There is up-regulation of a number of these genes such as HES5 and LFNG as well as DLL1 and NOTCH1 in the neural tube and brain. Mice die at midgestation with severe defects in somitogenesis, vasculogenesis, cardiogenesis and neurogenesis. The cax (compact axial skeleton) spontaneous mutation is a hypomorphic allele that reduces Pofut1 expression and protein levels leading to reduced Notch signaling. cax mutant embryos have somites of variable size, partly abnormal Lfng expression, defective anterior- posterior somite patterning and abnormal axial skeleton development. Mice have kinky and shortened tails and shortened body length (PubMed:19161597). Belongs to the glycosyltransferase 65 family. Name=Functional Glycomics Gateway - GTase; Note=Peptide- O-fucosyltransferase 1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_619"; angiogenesis somitogenesis endoplasmic reticulum carbohydrate metabolic process fucose metabolic process protein glycosylation protein O-linked glycosylation Notch signaling pathway nervous system development heart development fucosyltransferase activity regulation of Notch signaling pathway membrane transferase activity transferase activity, transferring glycosyl groups protein O-linked fucosylation peptide-O-fucosyltransferase activity uc008nhm.1 uc008nhm.2 uc008nhm.3 uc008nhm.4 
ENSMUST00000049872.9 Gpr183 ENSMUST00000049872.9 G protein-coupled receptor 183 (from RefSeq NM_183031.2) ENSMUST00000049872.1 ENSMUST00000049872.2 ENSMUST00000049872.3 ENSMUST00000049872.4 ENSMUST00000049872.5 ENSMUST00000049872.6 ENSMUST00000049872.7 ENSMUST00000049872.8 Ebi2 GP183_MOUSE Gpr183 NM_183031 Q3U1F6 Q3U6B2 Q7TMV7 Q80T40 uc007vaq.1 uc007vaq.2 uc007vaq.3 G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (PubMed:19597478, PubMed:19615922, PubMed:21844396, PubMed:21796211, PubMed:21796212, PubMed:27147029). Receptor for oxysterol 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796211, PubMed:21796212). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (PubMed:21796211, PubMed:21796212, PubMed:27147029). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (PubMed:21796211, PubMed:21796212). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:21948984, PubMed:22913878). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (PubMed:19615922, PubMed:19597478, PubMed:21844396). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (PubMed:19615922). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (PubMed:27147029). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (PubMed:27147029). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (PubMed:23682316, PubMed:23502855). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897, PubMed:27166278). Promotes osteoclast precursor migration to bone surfaces (PubMed:26438360). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (By similarity). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity). Homodimer and heterodimer. Heterodimerizes with CXCR5; leading to modulate the interaction between of CXCL13 and CXCR5. Cell membrane ; Multi-pass membrane protein Expressed in mature B-cells and increases in expression early after activation, before being down-regulated in germinal center B-cells (PubMed:19597478). Expressed in astrocytes (PubMed:25297897). Specifically expressed in CD4(+) dendritic cells but not in CD8(+) dendritic cells (PubMed:23682316, PubMed:23502855). Expressed in monocyte/osteoclasts precursors and mature osteoclasts (PubMed:26438360). Up-regulated during B-cell maturation in the bone marrow, and is expressed in mature recirculating B-cells in bone marrow, spleen and lymph nodes (PubMed:19597478). Up-regulated in B-cells after BCR and CD40 engagement (PubMed:19597478). Down-regulated by lipopolysaccharide (LPS) in astrocytes (PubMed:27166278). Expression is directly down-regulated by BCL6 (PubMed:25176650). Mice display a reduction in the early antibody response to a T-dependent antigen (PubMed:19597478). B-cells fail to move to the outer follicle at day 2 of activation, and instead are found in the follicle center (PubMed:19615922). Mice have normal numbers of B- and T-cells and organized follicles and T-cell compartments are present (PubMed:19615922). Mice show a decreased number of splenic CD4(+) dendritic cells and defective priming of T- and B-cell response (PubMed:23682316, PubMed:23502855). Reduced follicular helper T (Tfh) cells (PubMed:27147029). T-cells fail to accumulate in the outer T zone at either time point and instead remain dispersed throughout the T zone (PubMed:27147029). GSK682753A (8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3- [(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one), an inverse agonist, selectively inhibits the constitutive activity of GPR183 with high potency and efficacy. Belongs to the G-protein coupled receptor 1 family. adaptive immune response mature B cell differentiation involved in immune response immune system process dendritic cell chemotaxis G-protein coupled receptor activity plasma membrane humoral immune response signal transduction G-protein coupled receptor signaling pathway oxysterol binding T cell chemotaxis membrane integral component of membrane osteoclast differentiation leukocyte chemotaxis positive regulation of B cell proliferation dendritic cell homeostasis cell chemotaxis T follicular helper cell differentiation positive regulation of ERK1 and ERK2 cascade regulation of astrocyte chemotaxis uc007vaq.1 uc007vaq.2 uc007vaq.3 
ENSMUST00000049874.14 Agmo ENSMUST00000049874.14 alkylglycerol monooxygenase (from RefSeq NM_178767.5) ALKMO_MOUSE ENSMUST00000049874.1 ENSMUST00000049874.10 ENSMUST00000049874.11 ENSMUST00000049874.12 ENSMUST00000049874.13 ENSMUST00000049874.2 ENSMUST00000049874.3 ENSMUST00000049874.4 ENSMUST00000049874.5 ENSMUST00000049874.6 ENSMUST00000049874.7 ENSMUST00000049874.8 ENSMUST00000049874.9 NM_178767 Q3TR15 Q8BS35 Q8C7H5 Q8CAA6 Tmem195 uc007nkh.1 uc007nkh.2 uc007nkh.3 Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes (By similarity). Reaction=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2- saturated-alkyl)-sn-glycerol + O2 = (6R)-L-erythro-6,7- dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O; Xref=Rhea:RHEA:36255, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:43120, ChEBI:CHEBI:59560, ChEBI:CHEBI:73418, ChEBI:CHEBI:83957; EC=1.14.16.5; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BS35-1; Sequence=Displayed; Name=2; IsoId=Q8BS35-2; Sequence=VSP_027599; Name=3; IsoId=Q8BS35-3; Sequence=VSP_027600; Highly expressed in lever and small intestine. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the sterol desaturase family. TMEM195 subfamily. Sequence=BAC30271.1; Type=Erroneous initiation; Evidence=; Sequence=BAC34143.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; iron ion binding endoplasmic reticulum endoplasmic reticulum membrane membrane lipid metabolic process lipid biosynthetic process membrane integral component of membrane oxidoreductase activity ether lipid metabolic process glyceryl-ether monooxygenase activity oxidation-reduction process uc007nkh.1 uc007nkh.2 uc007nkh.3 
ENSMUST00000049877.3 Msgn1 ENSMUST00000049877.3 mesogenin 1 (from RefSeq NM_019544.1) ENSMUST00000049877.1 ENSMUST00000049877.2 MSGN1_MOUSE NM_019544 Q9JK54 uc007nau.1 uc007nau.2 uc007nau.3 Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation. Nucleus Specifically expressed in unsegmented paraxial mesoderm and its immediate progenitors and sharply down-regulated in presumptive somites. Not detectable at 6.5 dpc. At 7.5 dpc, expressed mainly in the posterior region of the embryo, lateral to the primitive streak where presumptive progenitors of paraxial mesoderm reside. Expression is largely excluded from the midline of the primitive streak. No expression is detected in the anterior part of the embryo. At 9.0 dpc, highly expressed in the caudal presomitic mesoderm. At 11.5 dpc, the primitive streak completely regresses, expression is observed exclusively in the tailbud. Expression remains in the tailbud until 13.5 dpc and begins to disappear between 13.5 and 14.5 dpc when the tailbud loses its potential to provide paraxial mesoderm cells. Mutant animals die during gestation. Premature death starts around 10.5 dpc. Severe morphological abnormalities, such as enlarged tailbud, kinked neural tube posterior to forelimb buds and reduced tissue mass in the interlimb domain become obvious at 9.0 dpc and thereafter. Head and anterior body structures, including the developing heart, appeared normal. In the trunk posterior to the forelimbs, there are no identifiable somites or segment patterning, although the anterior-most somites appeared normal, with decreases in somite size and disruption of myotomal patterning in somites 8-11. There are no detectable somites beyond somite 11. At 11.5 dpc, myotomes are absent from the trunk at the interlimb level and at 12.5 dpc, muscle is absent from the hindlimbs. The few fetuses surviving beyond 14.5 and 17.5 pdc lack a tail and show a grossly normal, but very thin body with relatively normal forelimbs and hindlimbs. At this stage, all vertebrae posterior to cervical level together with ribs are absent, while all cervical vertebrae are present, although the most posterior ones are sometimes malformed and fused. Other trunk skeletal structures that originate from lateral mesoderm, such as the sternum and scapula, form quite normally. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding mesoderm formation somitogenesis DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development segment specification cell differentiation positive regulation of transcription from RNA polymerase II promoter protein dimerization activity uc007nau.1 uc007nau.2 uc007nau.3 
ENSMUST00000049887.13 Nup42 ENSMUST00000049887.13 nucleoporin 42, transcript variant 1 (from RefSeq NM_153092.4) E9QL43 E9QL43_MOUSE ENSMUST00000049887.1 ENSMUST00000049887.10 ENSMUST00000049887.11 ENSMUST00000049887.12 ENSMUST00000049887.2 ENSMUST00000049887.3 ENSMUST00000049887.4 ENSMUST00000049887.5 ENSMUST00000049887.6 ENSMUST00000049887.7 ENSMUST00000049887.8 ENSMUST00000049887.9 NM_153092 Nupl2 uc008wqz.1 uc008wqz.2 uc008wqz.3 Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus, nuclear pore complex nuclear export signal receptor activity nucleus nuclear envelope nucleoplasm cytosol protein export from nucleus metal ion binding uc008wqz.1 uc008wqz.2 uc008wqz.3 
ENSMUST00000049896.13 Gpkow ENSMUST00000049896.13 G patch domain and KOW motifs (from RefSeq NM_173747.3) A0JLW7 A2AEU7 ENSMUST00000049896.1 ENSMUST00000049896.10 ENSMUST00000049896.11 ENSMUST00000049896.12 ENSMUST00000049896.2 ENSMUST00000049896.3 ENSMUST00000049896.4 ENSMUST00000049896.5 ENSMUST00000049896.6 ENSMUST00000049896.7 ENSMUST00000049896.8 ENSMUST00000049896.9 GPKOW_MOUSE NM_173747 Q56A08 Q6P5V0 Q8C1C3 uc009sma.1 uc009sma.2 uc009sma.3 uc009sma.4 RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12- type introns in pre-mRNAs (By similarity). Component of the minor spliceosome, which splices U12-type introns (By similarity). Interacts with PRKX, PRKACB and DHX16. Nucleus Phosphorylation regulates its ability to bind RNA. Belongs to the MOS2 family. Sequence=AAH92224.2; Type=Erroneous initiation; Evidence=; Sequence=AAI20680.1; Type=Erroneous initiation; Evidence=; Sequence=AAI25336.1; Type=Erroneous initiation; Evidence=; Sequence=BAC25949.1; Type=Erroneous initiation; Evidence=; mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus nucleoplasm spliceosomal complex mRNA processing RNA splicing uc009sma.1 uc009sma.2 uc009sma.3 uc009sma.4 
ENSMUST00000049908.11 Ssbp4 ENSMUST00000049908.11 single stranded DNA binding protein 4, transcript variant 7 (from RefSeq NM_133772.3) ENSMUST00000049908.1 ENSMUST00000049908.10 ENSMUST00000049908.2 ENSMUST00000049908.3 ENSMUST00000049908.4 ENSMUST00000049908.5 ENSMUST00000049908.6 ENSMUST00000049908.7 ENSMUST00000049908.8 ENSMUST00000049908.9 NM_133772 Q3U4B1 Q3U4B1_MOUSE Ssbp4 uc009max.1 uc009max.2 uc009max.3 Nucleus single-stranded DNA binding nucleus positive regulation of transcription from RNA polymerase II promoter uc009max.1 uc009max.2 uc009max.3 
ENSMUST00000049910.13 Otc ENSMUST00000049910.13 ornithine transcarbamylase, transcript variant 1 (from RefSeq NM_008769.5) ENSMUST00000049910.1 ENSMUST00000049910.10 ENSMUST00000049910.11 ENSMUST00000049910.12 ENSMUST00000049910.2 ENSMUST00000049910.3 ENSMUST00000049910.4 ENSMUST00000049910.5 ENSMUST00000049910.6 ENSMUST00000049910.7 ENSMUST00000049910.8 ENSMUST00000049910.9 NM_008769 Otc Q543H3 Q543H3_MOUSE uc009sqk.1 uc009sqk.2 uc009sqk.3 Reaction=carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate; Xref=Rhea:RHEA:19513, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:46911, ChEBI:CHEBI:57743, ChEBI:CHEBI:58228; EC=2.1.3.3; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:19515; Evidence=; Nitrogen metabolism; urea cycle; L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1. Homotrimer. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. urea cycle liver development ornithine carbamoyltransferase activity phospholipid binding cytoplasm mitochondrion mitochondrial inner membrane cellular amino acid metabolic process ornithine metabolic process ornithine catabolic process midgut development response to zinc ion amino acid binding transferase activity carboxyl- or carbamoyltransferase activity citrulline biosynthetic process response to nutrient levels response to insulin phosphate ion binding response to drug anion homeostasis protein homotrimerization response to biotin ammonia homeostasis uc009sqk.1 uc009sqk.2 uc009sqk.3 
ENSMUST00000049920.14 Ino80 ENSMUST00000049920.14 INO80 complex subunit (from RefSeq NM_026574.4) A2AQP8 ENSMUST00000049920.1 ENSMUST00000049920.10 ENSMUST00000049920.11 ENSMUST00000049920.12 ENSMUST00000049920.13 ENSMUST00000049920.2 ENSMUST00000049920.3 ENSMUST00000049920.4 ENSMUST00000049920.5 ENSMUST00000049920.6 ENSMUST00000049920.7 ENSMUST00000049920.8 ENSMUST00000049920.9 INO80_MOUSE Inoc1 Kiaa1259 NM_026574 Q6P7V0 Q6PCP1 Q6ZPV2 Q8C9T7 uc008ltt.1 uc008ltt.2 uc008ltt.3 uc008ltt.4 ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Activated upon binding to double stranded DNA or nucleosomes. Component of the chromatin remodeling INO80 complex; three different complex modules assemble on different domains of INO80. Interacts with DDB1. Interacts with transcriptional repressor protein YY1; the interaction recruits the INO80 complex to YY1 target genes. Interacts with YY1AP1. Interacts with tubulin alpha. Cytoplasm Nucleus Cytoplasm, cytoskeleton, spindle Chromosome Note=Localizes to the cytoplasm in quiescent cell. Associates with spindle microtubules during mitosis. Colocalizes with PCNA at replication forks during S- phase. Recruited to DNA damage sites in a ACTR8-dependent manner. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZPV2-1; Sequence=Displayed; Name=2; IsoId=Q6ZPV2-2; Sequence=VSP_020334; Widely expressed. The DBINO region is involved in binding to DNA. Belongs to the SNF2/RAD54 helicase family. mitotic sister chromatid segregation nucleotide binding double-strand break repair via homologous recombination DNA binding actin binding ATP binding nucleus nucleoplasm chromosome cytoplasm spindle cytoskeleton microtubule plasma membrane DNA repair double-strand break repair DNA recombination chromatin remodeling transcription, DNA-templated cellular response to DNA damage stimulus cell cycle DNA-dependent ATPase activity positive regulation of nuclear cell cycle DNA replication nuclear body hydrolase activity ATPase activity positive regulation of cell growth Ino80 complex cellular response to UV histone binding nucleosome mobilization alpha-tubulin binding ATP-dependent chromatin remodeling regulation of transcription from RNA polymerase II promoter in response to stress intermediate filament cytoskeleton positive regulation of transcription from RNA polymerase II promoter spindle assembly cell division UV-damage excision repair cellular response to ionizing radiation regulation of G1/S transition of mitotic cell cycle uc008ltt.1 uc008ltt.2 uc008ltt.3 uc008ltt.4 
ENSMUST00000049930.9 Tcf21 ENSMUST00000049930.9 transcription factor 21 (from RefSeq NM_011545.2) ENSMUST00000049930.1 ENSMUST00000049930.2 ENSMUST00000049930.3 ENSMUST00000049930.4 ENSMUST00000049930.5 ENSMUST00000049930.6 ENSMUST00000049930.7 ENSMUST00000049930.8 NM_011545 O35437 Pod1 Q3U023 TCF21_MOUSE uc007eps.1 uc007eps.2 uc007eps.3 uc007eps.4 uc007eps.5 Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May be involved in the organogenesis of the spleen and heart and in cardiac and coronary artery development. May function in the development and sex differentiation of gonad via transcriptional regulation of AD4BP/SF-1. Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 and binds the E box (5'-CANNTG- 3'). Nucleus Expressed at high levels in lung, kidney, gut, heart, ovary and podocytes (visceral glomerular epithelial cells). Also found in spleen, large intestine, uterus, bladder and testis. Expressed during embryogenesis specifically in mesodermally-derived cells that surround the epithelium of the developing gastrointestinal, genitourinary, respiratory systems and in spiral septum of the heart and in epicardial precursor cells fated to form the coronary arteries. Expression pattern is sex- and stage- dependent during gonadogenesis. At 13.5 dpc expressed at higher levels in testis than ovary. In 3-month old adults expression drastically decreased in testis while it increased in ovary showing an opposite sex-dependent pattern in adults compared with fetuses. Expression in other organs was similar between the adults and the fetal stage. negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ureteric bud development branching involved in ureteric bud morphogenesis morphogenesis of a branching structure kidney development vasculature development DNA binding protein binding nucleus sex determination sex differentiation animal organ morphogenesis branchiomeric skeletal muscle development epithelial cell differentiation regulation of histone deacetylation glomerulus development histone deacetylase binding bHLH transcription factor binding positive regulation of transcription from RNA polymerase II promoter protein dimerization activity lung alveolus development spleen development embryonic digestive tract morphogenesis reproductive structure development gland development androgen receptor binding Sertoli cell differentiation palate development lung morphogenesis lung vasculature development bronchiole development diaphragm development respiratory system development negative regulation of androgen receptor signaling pathway E-box binding metanephric mesenchymal cell differentiation metanephric glomerular capillary formation uc007eps.1 uc007eps.2 uc007eps.3 uc007eps.4 uc007eps.5 
ENSMUST00000049931.6 Spn ENSMUST00000049931.6 sialophorin, transcript variant 1 (from RefSeq NM_009259.5) ENSMUST00000049931.1 ENSMUST00000049931.2 ENSMUST00000049931.3 ENSMUST00000049931.4 ENSMUST00000049931.5 NM_009259 Q544C5 Q544C5_MOUSE Spn uc009jui.1 uc009jui.2 uc009jui.3 uc009jui.4 transmembrane signaling receptor activity membrane integral component of membrane interferon-gamma production regulation of T cell activation regulation of T cell migration uc009jui.1 uc009jui.2 uc009jui.3 uc009jui.4 
ENSMUST00000049937.13 Chtop ENSMUST00000049937.13 chromatin target of PRMT1, transcript variant 2 (from RefSeq NM_001293777.1) CHTOP_MOUSE ENSMUST00000049937.1 ENSMUST00000049937.10 ENSMUST00000049937.11 ENSMUST00000049937.12 ENSMUST00000049937.2 ENSMUST00000049937.3 ENSMUST00000049937.4 ENSMUST00000049937.5 ENSMUST00000049937.6 ENSMUST00000049937.7 ENSMUST00000049937.8 ENSMUST00000049937.9 Fop MNCb-1706 NM_001293777 Q0VBG3 Q3U7V6 Q3UF43 Q3V105 Q5XJG9 Q8C5N4 Q9CY57 Q9D7T3 Q9DB03 Q9DC54 Q9JJ95 uc008qcp.1 uc008qcp.2 uc008qcp.3 uc008qcp.4 Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the tumorigenicity of glioblastoma cells. Binds to 5- hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (PubMed:25284789). Interacts with PRMT1 and PRMT5 (PubMed:19858291, PubMed:22872859). Interacts with the 5FMC complex; the interaction is methylation-dependent. Interacts with FYTTD1, SET and PRC1 complex members CBX4, RNF2 and PHC2; the interactions are methylation- independent. Interacts with ZNF148 (PubMed:22872859). Interacts with WDR77 and ERH (By similarity). Q9CY57; Q9JIF0: Prmt1; NbExp=8; IntAct=EBI-6393116, EBI-519055; Q9CY57; Q8CIG8: Prmt5; NbExp=4; IntAct=EBI-6393116, EBI-2527009; Nucleus Nucleus, nucleolus Nucleus, nucleoplasm Nucleus speckle Note=Mostly associated with facultative heterochromatin. Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (By similarity). Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9CY57-1; Sequence=Displayed; Name=2; IsoId=Q9CY57-2; Sequence=VSP_011743; Name=3; IsoId=Q9CY57-3; Sequence=VSP_011744, VSP_011745; Name=4; IsoId=Q9CY57-4; Sequence=VSP_011743, VSP_011745; Name=5; IsoId=Q9CY57-5; Sequence=VSP_011743, VSP_011744, VSP_011745; Broadly expressed with highest levels found in thymus, spleen, and lymph nodes. Expressed in an erythroid progenitor cell line derived from fetal liver. Broadly expressed at 16.5 dpc. Asymmetrically methylated by PRMT1. Symmetrically methylated by PRMT5. [Isoform 2]: May be due to an intron retention. Sequence=BAA95102.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB25951.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC37084.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; transcription export complex in utero embryonic development RNA binding protein binding nucleus nucleoplasm nucleolus mRNA export from nucleus positive regulation of cell proliferation methyl-CpG binding nuclear speck positive regulation of histone methylation positive regulation of ATPase activity cytoplasmic ribonucleoprotein granule positive regulation of helicase activity uc008qcp.1 uc008qcp.2 uc008qcp.3 uc008qcp.4 
ENSMUST00000049941.12 Scn3b ENSMUST00000049941.12 sodium channel, voltage-gated, type III, beta, transcript variant 2 (from RefSeq NM_178227.4) ENSMUST00000049941.1 ENSMUST00000049941.10 ENSMUST00000049941.11 ENSMUST00000049941.2 ENSMUST00000049941.3 ENSMUST00000049941.4 ENSMUST00000049941.5 ENSMUST00000049941.6 ENSMUST00000049941.7 ENSMUST00000049941.8 ENSMUST00000049941.9 NM_178227 Q8BHK2 Q91Z99 SCN3B_MOUSE uc009ozj.1 uc009ozj.2 uc009ozj.3 Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non- covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds (By similarity). Membrane ; Single-pass type I membrane protein Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family. voltage-gated sodium channel complex voltage-gated ion channel activity sodium channel activity plasma membrane ion transport sodium ion transport nervous system development positive regulation of heart rate positive regulation of sodium ion transport membrane integral component of membrane sodium channel regulator activity sensory perception of pain sodium channel inhibitor activity Z disc regulation of ion transmembrane transport sodium ion transmembrane transport ion channel binding membrane depolarization cardiac muscle contraction regulation of atrial cardiac muscle cell membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization cardiac conduction protein localization to plasma membrane cardiac muscle cell action potential involved in contraction ventricular cardiac muscle cell action potential voltage-gated sodium channel activity involved in cardiac muscle cell action potential membrane depolarization during action potential membrane depolarization during cardiac muscle cell action potential atrial cardiac muscle cell action potential SA node cell action potential regulation of heart rate by cardiac conduction regulation of sodium ion transmembrane transporter activity uc009ozj.1 uc009ozj.2 uc009ozj.3 
ENSMUST00000049948.6 Asrgl1 ENSMUST00000049948.6 asparaginase like 1 (from RefSeq NM_025610.3) ASGL1_MOUSE ENSMUST00000049948.1 ENSMUST00000049948.2 ENSMUST00000049948.3 ENSMUST00000049948.4 ENSMUST00000049948.5 NM_025610 Q8C0M9 Q91WC8 Q9CVX3 uc008gon.1 uc008gon.2 uc008gon.3 Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp- L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. Reaction=H2O + L-asparagine = L-aspartate + NH4(+); Xref=Rhea:RHEA:21016, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29991, ChEBI:CHEBI:58048; EC=3.5.1.1; Evidence=; Reaction=Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.; EC=3.4.19.5; Evidence=; Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer. Cytoplasm Note=Midpiece of sperm tail. In retina localizes in photoreceptor inner segment (PubMed:27106100). High expression in the heart and brain while low to minimal expression in the other tissues. In ocular tissues, high levels is observed in the optic nerve and retina while relatively low levels of expression are detected in the iris-ciliary body, lens or retinal pigment epithelium. Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity. Belongs to the Ntn-hydrolase family. Sequence=AAH16106.1; Type=Erroneous initiation; Evidence=; Sequence=BAB24431.1; Type=Frameshift; Evidence=; Sequence=BAC25294.1; Type=Frameshift; Evidence=; photoreceptor inner segment asparaginase activity cytoplasm proteolysis peptidase activity beta-aspartyl-peptidase activity hydrolase activity asparagine catabolic process via L-aspartate uc008gon.1 uc008gon.2 uc008gon.3 
ENSMUST00000049956.5 Lrrc24 ENSMUST00000049956.5 leucine rich repeat containing 24 (from RefSeq NM_198119.2) ENSMUST00000049956.1 ENSMUST00000049956.2 ENSMUST00000049956.3 ENSMUST00000049956.4 LRC24_MOUSE NM_198119 Q14AD4 Q8BHA1 uc007wme.1 uc007wme.2 Membrane ; Single-pass membrane protein molecular_function extracellular space membrane integral component of membrane extracellular matrix positive regulation of synapse assembly uc007wme.1 uc007wme.2 
ENSMUST00000049972.6 Scg2 ENSMUST00000049972.6 secretogranin II, transcript variant 1 (from RefSeq NM_009129.3) Chgc ENSMUST00000049972.1 ENSMUST00000049972.2 ENSMUST00000049972.3 ENSMUST00000049972.4 ENSMUST00000049972.5 NM_009129 Q03517 Q80Y79 Q9CW80 SCG2_MOUSE Scg-2 uc007bqr.1 uc007bqr.2 uc007bqr.3 Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. Interacts with Secretogranin III/SCG3. Secreted. Note=Neuroendocrine and endocrine secretory granules. Binds calcium with a low-affinity. Belongs to the chromogranin/secretogranin protein family. MAPK cascade angiogenesis positive regulation of endothelial cell proliferation cytokine activity extracellular region extracellular space secretory granule dense core granule intracellular signal transduction chemoattractant activity eosinophil chemotaxis positive chemotaxis induction of positive chemotaxis neuronal dense core vesicle negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway uc007bqr.1 uc007bqr.2 uc007bqr.3 
ENSMUST00000049977.13 Dpf1 ENSMUST00000049977.13 double PHD fingers 1, transcript variant 1 (from RefSeq NM_013874.3) Baf45b DPF1_MOUSE Dpf1 ENSMUST00000049977.1 ENSMUST00000049977.10 ENSMUST00000049977.11 ENSMUST00000049977.12 ENSMUST00000049977.2 ENSMUST00000049977.3 ENSMUST00000049977.4 ENSMUST00000049977.5 ENSMUST00000049977.6 ENSMUST00000049977.7 ENSMUST00000049977.8 ENSMUST00000049977.9 NM_013874 Neud4 Q9QX65 Q9QX66 Q9QYA4 uc009gbo.1 uc009gbo.2 uc009gbo.3 May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9QX66-1; Sequence=Displayed; Name=2; IsoId=Q9QX66-2; Sequence=VSP_005608; Name=3; IsoId=Q9QX66-3; Sequence=VSP_005609; At embryonic stages, predominant expression in the nervous system. Expressed specifically in postmitotic neurons (at protein level). Low levels at embryonic day 9.5, and then sharp increase since embryonic day 12. In the developing forebrain and cerebellar primordium, strictly expressed in postmitotic neurons. Belongs to the requiem/DPF family. histone acetyltransferase complex nuclear chromatin nucleic acid binding histone acetyltransferase activity nucleus cytoplasm nervous system development zinc ion binding histone acetylation histone binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding nBAF complex uc009gbo.1 uc009gbo.2 uc009gbo.3 
ENSMUST00000049985.15 Hepacam2 ENSMUST00000049985.15 HEPACAM family member 2, transcript variant 1 (from RefSeq NM_178899.6) ENSMUST00000049985.1 ENSMUST00000049985.10 ENSMUST00000049985.11 ENSMUST00000049985.12 ENSMUST00000049985.13 ENSMUST00000049985.14 ENSMUST00000049985.2 ENSMUST00000049985.3 ENSMUST00000049985.4 ENSMUST00000049985.5 ENSMUST00000049985.6 ENSMUST00000049985.7 ENSMUST00000049985.8 ENSMUST00000049985.9 HECA2_MOUSE Miki NM_178899 Q4VAH7 uc009auz.1 uc009auz.2 uc009auz.3 Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma- tubulin ring complex and promotes centrosome maturation (By similarity). Golgi apparatus membrane ; Single-pass type I membrane protein Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody Note=In interphase, localizes to the Golgi apparatus. Localizes to centrosomes and spindles during prophase, prometaphase, and metaphase of mitosis, and to midbodies at telophase. Translocation to mitotic centrosomes is the result of poly-ADP- ribosylation (PARsylation). Poly-ADP-ribosylated (PARsylated) by tankyrase TNKS during late G2 and prophase, leading to translocation to mitotic centrosomes. N-glycosylated. Golgi membrane molecular_function cytoplasm Golgi apparatus centrosome microtubule organizing center spindle cytoskeleton cell cycle centrosome cycle membrane integral component of membrane midbody cell division uc009auz.1 uc009auz.2 uc009auz.3 
ENSMUST00000049994.8 Rimkla ENSMUST00000049994.8 ribosomal modification protein rimK-like family member A (from RefSeq NM_177572.4) ENSMUST00000049994.1 ENSMUST00000049994.2 ENSMUST00000049994.3 ENSMUST00000049994.4 ENSMUST00000049994.5 ENSMUST00000049994.6 ENSMUST00000049994.7 Fam80a NM_177572 Q6PFX8 Q8BXH0 RIMKA_MOUSE Rimk uc008umo.1 uc008umo.2 uc008umo.3 uc008umo.4 uc008umo.5 uc008umo.6 Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate. Reaction=ATP + L-glutamate + N-acetyl-L-aspartate = ADP + H(+) + N- acetyl-L-aspartyl-L-glutamate + phosphate; Xref=Rhea:RHEA:40035, ChEBI:CHEBI:15378, ChEBI:CHEBI:16953, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:76931, ChEBI:CHEBI:456216; EC=6.3.2.41; Evidence=; Reaction=2 ATP + 2 L-glutamate + N-acetyl-L-aspartate = 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate; Xref=Rhea:RHEA:40039, ChEBI:CHEBI:15378, ChEBI:CHEBI:16953, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:76935, ChEBI:CHEBI:456216; EC=6.3.2.42; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit. ; Cytoplasm Highly expressed in spinal cord and brain. N-acetyl-L-aspartyl-L-glutamate (NAAG) is the most abundant dipeptide present in vertebrate central nervous system (CNS). Belongs to the RimK family. nucleotide binding ATP binding cytoplasm cellular protein modification process ligase activity metal ion binding N-acetyl-L-aspartate-L-glutamate ligase activity uc008umo.1 uc008umo.2 uc008umo.3 uc008umo.4 uc008umo.5 uc008umo.6 
ENSMUST00000049995.10 Marchf10 ENSMUST00000049995.10 membrane associated ring-CH-type finger 10, transcript variant 1 (from RefSeq NM_172568.2) E9PX79 E9PX79_MOUSE ENSMUST00000049995.1 ENSMUST00000049995.2 ENSMUST00000049995.3 ENSMUST00000049995.4 ENSMUST00000049995.5 ENSMUST00000049995.6 ENSMUST00000049995.7 ENSMUST00000049995.8 ENSMUST00000049995.9 March10 Marchf10 NM_172568 uc007lxj.1 uc007lxj.2 uc007lxj.3 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. cellular_component biological_process zinc ion binding metal ion binding uc007lxj.1 uc007lxj.2 uc007lxj.3 
ENSMUST00000049997.14 Prokr2 ENSMUST00000049997.14 prokineticin receptor 2 (from RefSeq NM_144944.3) A2AMQ8 ENSMUST00000049997.1 ENSMUST00000049997.10 ENSMUST00000049997.11 ENSMUST00000049997.12 ENSMUST00000049997.13 ENSMUST00000049997.2 ENSMUST00000049997.3 ENSMUST00000049997.4 ENSMUST00000049997.5 ENSMUST00000049997.6 ENSMUST00000049997.7 ENSMUST00000049997.8 ENSMUST00000049997.9 Gpr73l1 NM_144944 PKR2_MOUSE Pkr2 Q80XQ0 Q8BIR4 Q8K458 uc008mmq.1 uc008mmq.2 uc008mmq.3 uc008mmq.4 Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity). Homodimer. Cell membrane ; Multi-pass membrane protein. Expressed in several regions of the brain, including paraventricular hypothalamic nucleus, dorsal medial hypothalamic nucleus, paratenial thalamic nuclei, paracentral thalamic nucleus, lateral habenular nucleus, lateral septal nucleus, lateral globus pallidus and amygdala. Highest expression seen in paraventricular thalamic nuclei and is also extensively expressed in the suprachiasmatic nucleus. Belongs to the G-protein coupled receptor 1 family. Sequence=BAC26971.1; Type=Erroneous initiation; Evidence=; G-protein coupled receptor activity neuropeptide Y receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway circadian rhythm membrane integral component of membrane cellular response to hormone stimulus uc008mmq.1 uc008mmq.2 uc008mmq.3 uc008mmq.4 
ENSMUST00000049999.9 Spin2c ENSMUST00000049999.9 spindlin family, member 2C, transcript variant 3 (from RefSeq NM_001418375.1) ENSMUST00000049999.1 ENSMUST00000049999.2 ENSMUST00000049999.3 ENSMUST00000049999.4 ENSMUST00000049999.5 ENSMUST00000049999.6 ENSMUST00000049999.7 ENSMUST00000049999.8 NM_001418375 Q6NVE3 SPI2C_MOUSE Spin2 uc009urb.1 uc009urb.2 uc009urb.3 May be involved in the regulation of cell cycle progression. Exhibits H3K4me3-binding activity. Interacts with C11orf84/SPINDOC. Nucleus Belongs to the SPIN/STSY family. nucleus nucleoplasm cytosol cell cycle gamete generation biological_process methylated histone binding regulation of cell cycle uc009urb.1 uc009urb.2 uc009urb.3 
ENSMUST00000050000.16 Stxbp1 ENSMUST00000050000.16 syntaxin binding protein 1, transcript variant 2 (from RefSeq NM_009295.2) A2ARS2 A2ARS3 A2ARS4 ENSMUST00000050000.1 ENSMUST00000050000.10 ENSMUST00000050000.11 ENSMUST00000050000.12 ENSMUST00000050000.13 ENSMUST00000050000.14 ENSMUST00000050000.15 ENSMUST00000050000.2 ENSMUST00000050000.3 ENSMUST00000050000.4 ENSMUST00000050000.5 ENSMUST00000050000.6 ENSMUST00000050000.7 ENSMUST00000050000.8 ENSMUST00000050000.9 NM_009295 O08599 Q5WAC6 Q8VD51 STXB1_MOUSE uc008jha.1 uc008jha.2 uc008jha.3 uc008jha.4 Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (PubMed:21445306, PubMed:28821673). May play a role in determining the specificity of intracellular fusion reactions (By similarity). Interacts with SYTL4 (By similarity). Interacts with STX1A; the interaction recruits SNARE complex components SNAP25 and VAMP2 and mediates neurotransmitter release from neurons (PubMed:21445306, PubMed:28821673). Interacts with alpha-synuclein/SNCA; this interaction controls SNCA self-replicating aggregation (By similarity). Interacts with RAB3A; this interaction promotes RAB3A dissociation from the vesicle membrane (By similarity). Interacts with CABP5 (By similarity). Interacts with APBA1 (PubMed:21445306). O08599-1; P31423: Grm4; Xeno; NbExp=2; IntAct=EBI-15809216, EBI-7974891; Cytoplasm, cytosol Membrane; Peripheral membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O08599-1; Sequence=Displayed; Name=2; IsoId=O08599-2; Sequence=VSP_010496; Expressed in the inner and outer plexiform layers of the retina (at protein level). Belongs to the STXBP/unc-18/SEC1 family. Sequence=CAM20726.1; Type=Erroneous gene model prediction; Evidence=; SNARE binding platelet degranulation developmental process involved in reproduction protein binding nucleus nucleoplasm cytoplasm mitochondrion cytosol cytoskeleton plasma membrane exocytosis vesicle docking involved in exocytosis neurotransmitter secretion neuromuscular synaptic transmission axon target recognition regulation of synaptic vesicle priming protein transport membrane synaptic vesicle priming synaptic vesicle maturation vesicle-mediated transport syntaxin-1 binding protein kinase binding protein domain specific binding syntaxin binding axon platelet alpha granule negative regulation of protein complex assembly regulation of vesicle fusion synaptic vesicle fusion to presynaptic active zone membrane negative regulation of synaptic transmission, GABAergic response to estradiol macromolecular complex SNARE complex assembly identical protein binding myelin sheath phospholipase binding positive regulation of mast cell degranulation negative regulation of neuron apoptotic process phagocytic vesicle positive regulation of exocytosis positive regulation of calcium ion-dependent exocytosis protein N-terminus binding perinuclear region of cytoplasm presynaptic active zone membrane protein stabilization long term synaptic depression platelet aggregation cellular response to interferon-gamma protein localization to plasma membrane presynapse postsynapse extrinsic component of presynaptic active zone membrane glutamatergic synapse presynaptic dense core vesicle exocytosis positive regulation of glutamate secretion, neurotransmission regulation of acrosomal vesicle exocytosis uc008jha.1 uc008jha.2 uc008jha.3 uc008jha.4 
ENSMUST00000050003.9 1700001O22Rik ENSMUST00000050003.9 RIKEN cDNA 1700001O22 gene, transcript variant 1 (from RefSeq NM_198000.3) 1700001O22Rik A2APZ1 A2APZ1_MOUSE ENSMUST00000050003.1 ENSMUST00000050003.2 ENSMUST00000050003.3 ENSMUST00000050003.4 ENSMUST00000050003.5 ENSMUST00000050003.6 ENSMUST00000050003.7 ENSMUST00000050003.8 NM_198000 uc008jcr.1 uc008jcr.2 uc008jcr.3 uc008jcr.4 uc008jcr.5 molecular_function cellular_component biological_process uc008jcr.1 uc008jcr.2 uc008jcr.3 uc008jcr.4 uc008jcr.5 
ENSMUST00000050011.10 Gm43302 ENSMUST00000050011.10 Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. (from UniProt L7N1X8) AK128993 ENSMUST00000050011.1 ENSMUST00000050011.2 ENSMUST00000050011.3 ENSMUST00000050011.4 ENSMUST00000050011.5 ENSMUST00000050011.6 ENSMUST00000050011.7 ENSMUST00000050011.8 ENSMUST00000050011.9 Gm43302 L7N1X8 L7N1X8_MOUSE uc008yla.1 uc008yla.2 uc008yla.3 uc008yla.4 Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. nucleotide binding GTPase activity GTP binding immune response symbiont-containing vacuole membrane cytoplasmic vesicle defense response to bacterium defense response to protozoan defense response to Gram-positive bacterium cellular response to interferon-gamma uc008yla.1 uc008yla.2 uc008yla.3 uc008yla.4 
ENSMUST00000050020.8 Jaml ENSMUST00000050020.8 junction adhesion molecule like (from RefSeq NM_001005421.4) Amica1 E9QNV7 ENSMUST00000050020.1 ENSMUST00000050020.2 ENSMUST00000050020.3 ENSMUST00000050020.4 ENSMUST00000050020.5 ENSMUST00000050020.6 ENSMUST00000050020.7 Gm638 JAML_MOUSE Jaml NM_001005421 Q5DTC4 Q80UL9 uc009pfd.1 uc009pfd.2 uc009pfd.3 uc009pfd.4 Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR. Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Cell membrane ; Single-pass type I membrane protein Cell junction Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts. Expressed by gamma-delta intraepithelial T cells (at protein level). The Ig-like V-type domain 1 mediates interaction with CXADR (PubMed:20813954). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:20813955). Belongs to the immunoglobulin superfamily. immune system process integrin binding plasma membrane bicellular tight junction cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules membrane integral component of membrane cell junction neutrophil chemotaxis monocyte extravasation protein homodimerization activity gamma-delta T cell activation cell adhesion molecule binding leukocyte migration positive regulation of epithelial cell proliferation involved in wound healing neutrophil extravasation uc009pfd.1 uc009pfd.2 uc009pfd.3 uc009pfd.4 
ENSMUST00000050027.9 Ccn3 ENSMUST00000050027.9 cellular communication network factor 3 (from RefSeq NM_010930.5) CCN3_MOUSE ENSMUST00000050027.1 ENSMUST00000050027.2 ENSMUST00000050027.3 ENSMUST00000050027.4 ENSMUST00000050027.5 ENSMUST00000050027.6 ENSMUST00000050027.7 ENSMUST00000050027.8 NM_010930 Nov Q64299 Q8CA67 uc007vrn.1 uc007vrn.2 uc007vrn.3 uc007vrn.4 Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival. Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (By similarity). Involved in bone regeneration as a negative regulator (PubMed:23653360). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (By similarity). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (PubMed:23705021). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF- kappaB signaling pathway (By similarity). Contributes to the control and coordination of inflammatory processes in atherosclerosis (PubMed:24722330). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (By similarity). Interacts with FBLN1. Interacts (via CTCK domain) with NOTCH1 (via the EGF-like repeat region). Interacts with GJA1/CX43. Interacts with ITGA5:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB5. Interacts with ZDHHC22; the interaction may lead to CCN3 palmitoylation (PubMed:29287726). Secreted toplasm Cell junction, gap junction Note=Localizes at the gap junction in presence of GJA1. Expressed in large vessels including the ascending aorta, carotid arteries, and the thoracic aorta, in medium-sized vessels such as coronary arteries and small pulmonary veins and also in small vessels. In addition, also found to be present in the heart (at protein level) (PubMed:21063504). Expressed in astrocytes (at protein level) (PubMed:15213231). Detected in brain, bone, lung and muscle tissues (PubMed:20139355, PubMed:23653360). Expressed in skin, expression highly increases 5 days post-wounding, peaking on the 7th day to decline after 9 days (PubMed:15611078). Expressed in pancreatic ducts and beta-cell islets (PubMed:23705021). Up-regulated in the early phase of bone regeneration. Expression is reduced in atherosclerosis progression. May be palmitoylated on Cys-241, which is important for extracellular secretion. Mutants develop normally but have enhanced arterial neointimal hyperplasia in response to injury (PubMed:20139355). Animals show an accelerated bone regeneration comparing to in wild-type mice (PubMed:24722330). Belongs to the CCN family. angiogenesis chondrocyte differentiation Notch binding integrin binding insulin-like growth factor binding extracellular region extracellular space cytoplasm gap junction cell adhesion signal transduction growth factor activity heparin binding regulation of gene expression fibroblast migration negative regulation of myotube differentiation smooth muscle cell migration cell junction negative regulation of cell growth axon dendrite extracellular matrix cell adhesion mediated by integrin endothelial cell chemotaxis neuronal cell body intracellular membrane-bounded organelle type B pancreatic cell proliferation positive regulation of Notch signaling pathway negative regulation of insulin secretion smooth muscle cell proliferation negative regulation of inflammatory response cell chemotaxis negative regulation of SMAD protein import into nucleus negative regulation of cell death hematopoietic stem cell homeostasis endothelial cell-cell adhesion negative regulation of monocyte chemotaxis negative regulation of NIK/NF-kappaB signaling negative regulation of chondrocyte proliferation negative regulation of sensory perception of pain bone regeneration uc007vrn.1 uc007vrn.2 uc007vrn.3 uc007vrn.4 
ENSMUST00000050029.8 Six1 ENSMUST00000050029.8 sine oculis-related homeobox 1 (from RefSeq NM_009189.3) ENSMUST00000050029.1 ENSMUST00000050029.2 ENSMUST00000050029.3 ENSMUST00000050029.4 ENSMUST00000050029.5 ENSMUST00000050029.6 ENSMUST00000050029.7 NM_009189 Q62231 Q8CIL7 SIX1_MOUSE uc007nwa.1 uc007nwa.2 uc007nwa.3 uc007nwa.4 Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (PubMed:12215533, PubMed:12668636, PubMed:12834866, PubMed:14628042, PubMed:14695375). Plays an important role in the development of several organs, including kidney, muscle and inner ear (PubMed:12668636, PubMed:12783782, PubMed:12834866, PubMed:14628042, PubMed:14695375). Depending on context, functions as a transcriptional repressor or activator (PubMed:14628042). Lacks an activation domain, and requires interaction with EYA family members for transcription activation (By similarity). Mediates nuclear translocation of EYA1 and EYA2 (By similarity). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (By similarity). Regulates the expression of numerous genes, including MYC, CCNA1, CCND1 and EZR (PubMed:16488997). Acts as an activator of the IGFBP5 promoter, probably coactivated by EYA2 (PubMed:11978764). Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (PubMed:14628042). During myogenesis, seems to act together with EYA2 and DACH2. Regulates the expression of CCNA1 (By similarity). Promotes brown adipocyte differentiation (PubMed:27923061). Interacts with DACH1 (PubMed:14628042). Interacts with EYA1 (PubMed:15141091). Interacts with EYA2 (By similarity). Interacts with CDH1 (By similarity). Interacts with TBX18 (By similarity). Interacts with CEBPA (PubMed:27923061). Interacts with CEBPB (PubMed:27923061). Interacts with EBF2 (PubMed:27923061). Q62231; P97767: Eya1; NbExp=3; IntAct=EBI-1368483, EBI-1368503; Nucleus Cytoplasm Expressed in phalangeal tendons and in skeletal muscle and in head and body mesenchyme. First expressed at 8.2-8.5 dpc of embryo development in the anterior head mesoderm and developing pharyngeal pouches. Expression in the developing limb begins at 11 dpc and is more pronounced dorsally. It progresses into the developing phalanges at 13.5 dpc. In the developing inner ear detected in the otic placode and the surrounding surface ectoderm at 8.5 dpc. Expression became prominent at the invaginating otic pit and the nascent otic vesicle at 9.5 dpc. At 10.5 dpc, expression was limited to the ventral half of the otic vesicle. Subsequently, the expression became gradually restricted to the cochlear region at 11.5 dpc and 12.5 dpc. At later stages detected exclusively in the cochlea at 14.5 dpc, and the expression in the cochlear duct persisted in the neonate. In the developing kidney, is expressed in the uninduced metanephric mesenchyme at 10.5 dpc and in the induced mesenchyme around the ureteric bud at 11.5 dpc. At 17.5 dpc to P0, expression becomes restricted to a subpopulation of collecting tubule epithelial cells. Phosphorylated during interphase; becomes hyperphosphorylated during mitosis. Hyperphosphorylation impairs binding to promoter elements (By similarity). Ubiquitinated by the anaphase promoting complex (APC), leading to its proteasomal degradation. Perinatal lethality. Mice show failure in renal organogenesis, a severe reduction of most migratory hypaxial muscles including those of the forelimb, diaphragm and tongue, and severe rib- cage deformation. Besides, mice display craniofacial defects, including loss of inner ear structures. Pax2, Six2 and Sall1 expression is markedly reduced in the metanephric mesenchyme at 10.5 dpc during kidney development. Mice lacking both Six1 and Eya1 show defects in kidney development, complete absence of hypaxial muscle, severe reduction in epaxial muscle and a 5-10-fold by volume smaller pituarity than the wild-type gland. Belongs to the SIX/Sine oculis homeobox family. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ureteric bud development branching involved in ureteric bud morphogenesis organ induction kidney development outflow tract morphogenesis DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex nucleolus cytoplasm regulation of transcription, DNA-templated apoptotic process multicellular organism development pattern specification process skeletal muscle tissue development sensory perception of sound regulation of synaptic growth at neuromuscular junction regulation of gene expression regulation of skeletal muscle satellite cell proliferation regulation of skeletal muscle cell proliferation facial nerve morphogenesis neurogenesis epithelial cell differentiation thyroid gland development olfactory placode formation regulation of protein localization protein localization to nucleus aorta morphogenesis inner ear morphogenesis middle ear morphogenesis negative regulation of apoptotic process negative regulation of neuron apoptotic process sequence-specific DNA binding tongue development transcription regulatory region DNA binding regulation of neuron differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter thymus development neuron fate specification generation of neurons embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis skeletal system morphogenesis skeletal muscle fiber development inner ear development anatomical structure development regulation of epithelial cell proliferation myoblast migration pharyngeal system development myotome development fungiform papilla morphogenesis trigeminal ganglion development otic vesicle development metanephric mesenchyme development regulation of branch elongation involved in ureteric bud branching positive regulation of ureteric bud formation mesonephric tubule formation ureter smooth muscle cell differentiation positive regulation of secondary heart field cardioblast proliferation cochlea morphogenesis positive regulation of branching involved in ureteric bud morphogenesis cellular response to 3,3',5-triiodo-L-thyronine positive regulation of mesenchymal cell proliferation involved in ureter development regulation of skeletal muscle cell differentiation uc007nwa.1 uc007nwa.2 uc007nwa.3 uc007nwa.4 
ENSMUST00000050034.3 Pcdhb15 ENSMUST00000050034.3 protocadherin beta 15 (from RefSeq NM_053140.3) ENSMUST00000050034.1 ENSMUST00000050034.2 NM_053140 Pcdhb15 Q91Y04 Q91Y04_MOUSE uc008eqa.1 uc008eqa.2 uc008eqa.3 molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eqa.1 uc008eqa.2 uc008eqa.3 
ENSMUST00000050047.4 D630023F18Rik ENSMUST00000050047.4 RIKEN cDNA D630023F18 gene, transcript variant 1 (from RefSeq NM_175293.4) CB080_MOUSE ENSMUST00000050047.1 ENSMUST00000050047.2 ENSMUST00000050047.3 NM_175293 Q8C3M9 uc007bhm.1 uc007bhm.2 uc007bhm.3 uc007bhm.4 molecular_function cellular_component biological_process uc007bhm.1 uc007bhm.2 uc007bhm.3 uc007bhm.4 
ENSMUST00000050063.9 Arf6 ENSMUST00000050063.9 ADP-ribosylation factor 6 (from RefSeq NM_007481.3) Arf6 ENSMUST00000050063.1 ENSMUST00000050063.2 ENSMUST00000050063.3 ENSMUST00000050063.4 ENSMUST00000050063.5 ENSMUST00000050063.6 ENSMUST00000050063.7 ENSMUST00000050063.8 NM_007481 Q3U0D7 Q3U0D7_MOUSE uc033gdt.1 uc033gdt.2 uc033gdt.3 Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Cell membrane ; Lipid-anchor Cell projection, filopodium membrane ; Lipid-anchor Cell projection, ruffle Cleavage furrow Endosome membrane ; Lipid-anchor Midbody, Midbody ring Recycling endosome membrane ; Lipid-anchor Belongs to the small GTPase superfamily. Arf family. nucleotide binding ruffle GTPase activity GTP binding endosome early endosome plasma membrane cell cortex endocytic vesicle positive regulation of actin filament polymerization cortical actin cytoskeleton organization filopodium membrane thioesterase binding cleavage furrow endocytic recycling regulation of Rac protein signal transduction protein localization to endosome synaptic vesicle endocytosis positive regulation of protein secretion regulation of filopodium assembly recycling endosome recycling endosome membrane regulation of dendritic spine development positive regulation of protein homodimerization activity Flemming body ruffle assembly presynapse glutamatergic synapse maintenance of postsynaptic density structure regulation of presynapse assembly cellular response to nerve growth factor stimulus negative regulation of dendrite development uc033gdt.1 uc033gdt.2 uc033gdt.3 
ENSMUST00000050067.10 Hectd3 ENSMUST00000050067.10 HECT domain E3 ubiquitin protein ligase 3 (from RefSeq NM_175244.4) B1AUL1 ENSMUST00000050067.1 ENSMUST00000050067.2 ENSMUST00000050067.3 ENSMUST00000050067.4 ENSMUST00000050067.5 ENSMUST00000050067.6 ENSMUST00000050067.7 ENSMUST00000050067.8 ENSMUST00000050067.9 HECD3_MOUSE NM_175244 Q3TN76 Q3U487 Q641P3 Q8BQ74 Q8R1L6 uc008uht.1 uc008uht.2 uc008uht.3 E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP (By similarity). Mediates also ubiquitination of STX8. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Protein modification; protein ubiquitination. Interacts with TRIOBP (By similarity). Interacts with STX8. Cytoplasm, perinuclear region Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U487-1; Sequence=Displayed; Name=2; IsoId=Q3U487-2; Sequence=VSP_019441; ubiquitin-protein transferase activity cytoplasm protein ubiquitination transferase activity syntaxin binding proteasome-mediated ubiquitin-dependent protein catabolic process perinuclear region of cytoplasm uc008uht.1 uc008uht.2 uc008uht.3 
ENSMUST00000050069.9 Rbm12b1 ENSMUST00000050069.9 Sequence=AAH54081.1; Type=Miscellaneous discrepancy; Note=Possible contaminating sequence. The N-terminal 4 residues do not match the underlying genomic sequence.; Evidence=; (from UniProt Q80YR9) AK030861 B1AZ74 ENSMUST00000050069.1 ENSMUST00000050069.2 ENSMUST00000050069.3 ENSMUST00000050069.4 ENSMUST00000050069.5 ENSMUST00000050069.6 ENSMUST00000050069.7 ENSMUST00000050069.8 Q7TQK7 Q80YR9 Q8CD70 Q9CRY6 R12BA_MOUSE Rbm12b Rbm12ba uc008san.1 uc008san.2 uc008san.3 uc008san.4 uc008san.5 uc008san.6 Sequence=AAH54081.1; Type=Miscellaneous discrepancy; Note=Possible contaminating sequence. The N-terminal 4 residues do not match the underlying genomic sequence.; Evidence=; nucleic acid binding RNA binding cellular_component biological_process uc008san.1 uc008san.2 uc008san.3 uc008san.4 uc008san.5 uc008san.6 
ENSMUST00000050078.13 Sdf4 ENSMUST00000050078.13 stromal cell derived factor 4, transcript variant 1 (from RefSeq NM_011341.5) CAB45_MOUSE Cab45 ENSMUST00000050078.1 ENSMUST00000050078.10 ENSMUST00000050078.11 ENSMUST00000050078.12 ENSMUST00000050078.2 ENSMUST00000050078.3 ENSMUST00000050078.4 ENSMUST00000050078.5 ENSMUST00000050078.6 ENSMUST00000050078.7 ENSMUST00000050078.8 ENSMUST00000050078.9 NM_011341 Q3TK84 Q3TQP8 Q61112 Q61113 uc008wfs.1 uc008wfs.2 uc008wfs.3 uc008wfs.4 This gene encodes a member of the CREC family. The encoded protein contains multiple calcium-binding EF-hand motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. Golgi apparatus lumen Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61112-1; Sequence=Displayed; Name=2; IsoId=Q61112-2; Sequence=VSP_037450, VSP_037451; Ubiquitous. Binds calcium, probably via its EF-hands. Belongs to the CREC family. calcium ion binding cytoplasm late endosome endoplasmic reticulum Golgi apparatus Golgi lumen UV protection calcium ion regulated exocytosis cerebellum development identical protein binding fat cell differentiation response to ethanol metal ion binding zymogen granule exocytosis plasma membrane uc008wfs.1 uc008wfs.2 uc008wfs.3 uc008wfs.4 
ENSMUST00000050092.7 Zfp518a ENSMUST00000050092.7 zinc finger protein 518A (from RefSeq NM_028319.1) B2RRF6 ENSMUST00000050092.1 ENSMUST00000050092.2 ENSMUST00000050092.3 ENSMUST00000050092.4 ENSMUST00000050092.5 ENSMUST00000050092.6 Kiaa0335 NM_028319 Q9CSF6 Z518A_MOUSE Zfp518 Znf518 Znf518a uc008hlk.1 uc008hlk.2 Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus metal ion binding uc008hlk.1 uc008hlk.2 
ENSMUST00000050101.9 Zfp322a ENSMUST00000050101.9 zinc finger protein 322A, transcript variant 2 (from RefSeq NM_172586.4) ENSMUST00000050101.1 ENSMUST00000050101.2 ENSMUST00000050101.3 ENSMUST00000050101.4 ENSMUST00000050101.5 ENSMUST00000050101.6 ENSMUST00000050101.7 ENSMUST00000050101.8 NM_172586 Q8BZ89 Q8K0A0 Q91W42 ZN322_MOUSE Znf322 Znf322a uc007ptn.1 uc007ptn.2 uc007ptn.3 uc007ptn.4 Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells. Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes. Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly. Promotes inhibition of MAPK signaling during embryonic stem cell differentiation. Interacts with POU5F1. Nucleus Cytoplasm Note=Mainly found in the nucleus. Expressed in the inner cell mass of the blastocyst during preimplantation stage embryonic development. Significantly enhances POU5F1/OCT4-SOX2-KLF4-MYC (OSKM) mediated reprogramming of mouse embryonic fibroblasts into induced pluripotent stem cells, and can also substitute for SOX2 in this process. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAH32268.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm centrosome cytosol regulation of transcription, DNA-templated enhancer binding sequence-specific DNA binding metal ion binding positive regulation of stem cell population maintenance uc007ptn.1 uc007ptn.2 uc007ptn.3 uc007ptn.4 
ENSMUST00000050103.2 Neurog3 ENSMUST00000050103.2 neurogenin 3 (from RefSeq NM_009719.6) ENSMUST00000050103.1 NM_009719 Neurog3 Q548G3 Q548G3_MOUSE uc007fgu.1 uc007fgu.2 negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding double-stranded DNA binding nucleus cytoplasm regulation of transcription, DNA-templated spinal cord development neurogenesis forebrain development hindbrain development endocrine pancreas development positive regulation of cell differentiation positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter protein dimerization activity uc007fgu.1 uc007fgu.2 
ENSMUST00000050104.8 Gprc5a ENSMUST00000050104.8 G protein-coupled receptor, family C, group 5, member A (from RefSeq NM_181444.5) ENSMUST00000050104.1 ENSMUST00000050104.2 ENSMUST00000050104.3 ENSMUST00000050104.4 ENSMUST00000050104.5 ENSMUST00000050104.6 ENSMUST00000050104.7 G5E8C3 G5E8C3_MOUSE Gprc5a NM_181444 uc009ele.1 uc009ele.2 uc009ele.3 uc009ele.4 uc009ele.5 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity nucleolus plasma membrane G-protein coupled receptor signaling pathway membrane integral component of membrane vesicle intracellular membrane-bounded organelle uc009ele.1 uc009ele.2 uc009ele.3 uc009ele.4 uc009ele.5 
ENSMUST00000050106.5 Krtap4-13 ENSMUST00000050106.5 keratin associated protein 4-13 (from RefSeq NM_027087.3) ENSMUST00000050106.1 ENSMUST00000050106.2 ENSMUST00000050106.3 ENSMUST00000050106.4 Krtap4-13 NM_027087 Q9D7P3 Q9D7P3_MOUSE uc057kmj.1 uc057kmj.2 uc057kmj.3 molecular_function cellular_component intermediate filament biological_process keratin filament uc057kmj.1 uc057kmj.2 uc057kmj.3 
ENSMUST00000050120.4 Kctd4 ENSMUST00000050120.4 potassium channel tetramerisation domain containing 4 (from RefSeq NM_026214.3) ENSMUST00000050120.1 ENSMUST00000050120.2 ENSMUST00000050120.3 KCTD4_MOUSE NM_026214 Q8CCQ3 Q9CYK4 Q9D7X1 uc007urc.1 uc007urc.2 uc007urc.3 molecular_function cellular_component biological_process protein homooligomerization uc007urc.1 uc007urc.2 uc007urc.3 
ENSMUST00000050125.9 2900026A02Rik ENSMUST00000050125.9 RIKEN cDNA 2900026A02 gene, transcript variant 2 (from RefSeq NM_172884.3) B2RVT5 ENSMUST00000050125.1 ENSMUST00000050125.2 ENSMUST00000050125.3 ENSMUST00000050125.4 ENSMUST00000050125.5 ENSMUST00000050125.6 ENSMUST00000050125.7 ENSMUST00000050125.8 K1671_MOUSE Kiaa1671 NM_172884 Q5DTV9 Q8BRV5 uc008yua.1 uc008yua.2 uc008yua.3 uc008yua.4 molecular_function cellular_component biological_process uc008yua.1 uc008yua.2 uc008yua.3 uc008yua.4 
ENSMUST00000050129.6 Cox7b2 ENSMUST00000050129.6 cytochrome c oxidase subunit 7B2 (from RefSeq NM_030052.3) Cox7b2 ENSMUST00000050129.1 ENSMUST00000050129.2 ENSMUST00000050129.3 ENSMUST00000050129.4 ENSMUST00000050129.5 NM_030052 Q9D2H1 Q9D2H1_MOUSE uc008xqx.1 uc008xqx.2 uc008xqx.3 Energy metabolism; oxidative phosphorylation. Membrane ; Single- pass membrane protein Belongs to the cytochrome c oxidase VIIb family. molecular_function cytochrome-c oxidase activity mitochondrial respiratory chain electron transport chain respiratory chain complex IV hydrogen ion transmembrane transport uc008xqx.1 uc008xqx.2 uc008xqx.3 
ENSMUST00000050140.6 Tmem88 ENSMUST00000050140.6 transmembrane protein 88 (from RefSeq NM_025915.4) ENSMUST00000050140.1 ENSMUST00000050140.2 ENSMUST00000050140.3 ENSMUST00000050140.4 ENSMUST00000050140.5 NM_025915 Q497Z2 Q8BRC2 Q9D0N8 TMM88_MOUSE uc007jqc.1 uc007jqc.2 uc007jqc.3 uc007jqc.4 Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity). Interacts (via C-terminus) with DVL1. Q9D0N8; P51141: Dvl1; NbExp=2; IntAct=EBI-6136970, EBI-1538407; Cell membrane ; Multi-pass membrane protein. Belongs to the TMEM88 family. protein binding cytosol plasma membrane multicellular organism development membrane integral component of membrane Wnt signaling pathway PDZ domain binding protein stabilization protein localization to plasma membrane negative regulation of canonical Wnt signaling pathway uc007jqc.1 uc007jqc.2 uc007jqc.3 uc007jqc.4 
ENSMUST00000050148.5 Cdc37l1 ENSMUST00000050148.5 cell division cycle 37-like 1, transcript variant 7 (from RefSeq NR_165054.1) CD37L_MOUSE ENSMUST00000050148.1 ENSMUST00000050148.2 ENSMUST00000050148.3 ENSMUST00000050148.4 NR_165054 Q3TNC7 Q8BP15 Q8C892 Q8C8X2 Q9CU15 Q9CZP7 uc008hcv.1 uc008hcv.2 uc008hcv.3 uc008hcv.4 This gene encodes a protein related to the Hsp90 co-chaperone Cdc37. This protein may have a role in mediating interactions between the Hsp90 complex and other proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.5046444.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. Self-associates. Forms complexes with Hsp70 and Hsp90. Interacts with CDC37, FKBP4, PPID and STIP1. Cytoplasm Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9CZP7-1; Sequence=Displayed; Name=2; IsoId=Q9CZP7-2; Sequence=VSP_031215, VSP_031216; Name=3; IsoId=Q9CZP7-3; Sequence=VSP_031214, VSP_031217; Name=4; IsoId=Q9CZP7-4; Sequence=VSP_031213, VSP_031218; Belongs to the CDC37 family. cytoplasm cytosol protein folding heat shock protein binding protein stabilization unfolded protein binding chaperone binding uc008hcv.1 uc008hcv.2 uc008hcv.3 uc008hcv.4 
ENSMUST00000050160.6 AU021092 ENSMUST00000050160.6 expressed sequence AU021092, transcript variant 7 (from RefSeq NR_184425.1) B7ZWC6 CP089_MOUSE ENSMUST00000050160.1 ENSMUST00000050160.2 ENSMUST00000050160.3 ENSMUST00000050160.4 ENSMUST00000050160.5 NR_184425 Q3UST5 uc012aaz.1 uc012aaz.2 uc012aaz.3 Homodimer. Secreted Predominantly expressed in thyroid tissue. From embryonic day (E) 17.5 onward in the developing mouse thyroid and lung. Glycosylated. Belongs to the UPF0764 family. extracellular region cytosol biological_process membrane protein homodimerization activity uc012aaz.1 uc012aaz.2 uc012aaz.3 
ENSMUST00000050178.13 Ccdc60 ENSMUST00000050178.13 coiled-coil domain containing 60, transcript variant 1 (from RefSeq NM_177759.3) B2RX39 CCD60_MOUSE ENSMUST00000050178.1 ENSMUST00000050178.10 ENSMUST00000050178.11 ENSMUST00000050178.12 ENSMUST00000050178.2 ENSMUST00000050178.3 ENSMUST00000050178.4 ENSMUST00000050178.5 ENSMUST00000050178.6 ENSMUST00000050178.7 ENSMUST00000050178.8 ENSMUST00000050178.9 NM_177759 Q6DIA4 Q6PAQ3 Q8C4J0 uc008zey.1 uc008zey.2 uc008zey.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C4J0-1; Sequence=Displayed; Name=2; IsoId=Q8C4J0-2; Sequence=VSP_019251, VSP_019252; molecular_function cellular_component biological_process uc008zey.1 uc008zey.2 uc008zey.3 
ENSMUST00000050183.7 Uaca ENSMUST00000050183.7 uveal autoantigen with coiled-coil domains and ankyrin repeats, transcript variant 1 (from RefSeq NM_028283.3) A0A0R4J0S7 A0A0R4J0S7_MOUSE ENSMUST00000050183.1 ENSMUST00000050183.2 ENSMUST00000050183.3 ENSMUST00000050183.4 ENSMUST00000050183.5 ENSMUST00000050183.6 NM_028283 Uaca uc009pzi.1 uc009pzi.2 nucleus cytosol apoptotic signaling pathway regulation of NIK/NF-kappaB signaling uc009pzi.1 uc009pzi.2 
ENSMUST00000050207.10 Tefm ENSMUST00000050207.10 transcription elongation factor, mitochondrial (from RefSeq NM_183275.2) ENSMUST00000050207.1 ENSMUST00000050207.2 ENSMUST00000050207.3 ENSMUST00000050207.4 ENSMUST00000050207.5 ENSMUST00000050207.6 ENSMUST00000050207.7 ENSMUST00000050207.8 ENSMUST00000050207.9 NM_183275 Q5SSK3 TEFM_MOUSE uc007klj.1 uc007klj.2 uc007klj.3 Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery (By similarity). Interacts with POLRMT. Mitochondrion matrix Mitochondrion matrix, mitochondrion nucleoid Belongs to the TEFM family. nucleic acid binding mitochondrion mitochondrial matrix oxidative phosphorylation DNA metabolic process transcription from mitochondrial promoter transcription elongation from mitochondrial promoter DNA polymerase processivity factor activity mitochondrial nucleoid ribonucleoprotein complex uc007klj.1 uc007klj.2 uc007klj.3 
ENSMUST00000050211.7 Tk2 ENSMUST00000050211.7 thymidine kinase 2, mitochondrial, transcript variant 1 (from RefSeq NM_021028.3) ENSMUST00000050211.1 ENSMUST00000050211.2 ENSMUST00000050211.3 ENSMUST00000050211.4 ENSMUST00000050211.5 ENSMUST00000050211.6 NM_021028 Q8BN51 Q8BN51_MOUSE Tk2 uc009naa.1 uc009naa.2 uc009naa.3 uc009naa.4 Belongs to the DCK/DGK family. nucleotide binding deoxycytidine kinase activity thymidine kinase activity ATP binding mitochondrion nucleobase-containing compound metabolic process deoxyribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process kinase activity phosphorylation nucleoside kinase activity deoxycytidine metabolic process thymidine metabolic process uc009naa.1 uc009naa.2 uc009naa.3 uc009naa.4 
ENSMUST00000050214.9 Akap8l ENSMUST00000050214.9 A kinase anchor protein 8-like, transcript variant 10 (from RefSeq NR_175386.1) Akap8l ENSMUST00000050214.1 ENSMUST00000050214.2 ENSMUST00000050214.3 ENSMUST00000050214.4 ENSMUST00000050214.5 ENSMUST00000050214.6 ENSMUST00000050214.7 ENSMUST00000050214.8 NR_175386 Q5RL57 Q5RL57_MOUSE uc008bwj.1 uc008bwj.2 uc008bwj.3 uc008bwj.4 Belongs to the AKAP95 family. chromatin DNA binding lamin binding nucleus cytoplasm mRNA processing mitotic chromosome condensation regulation of mRNA export from nucleus kinase activity phosphorylation nuclear matrix nuclear speck positive regulation of histone deacetylation regulation of histone phosphorylation histone deacetylase binding cell cycle G2/M phase transition positive regulation of transcription from RNA polymerase II promoter nuclear envelope disassembly ribonucleoprotein complex uc008bwj.1 uc008bwj.2 uc008bwj.3 uc008bwj.4 
ENSMUST00000050226.7 Smtnl2 ENSMUST00000050226.7 smoothelin-like 2 (from RefSeq NM_177776.3) ENSMUST00000050226.1 ENSMUST00000050226.2 ENSMUST00000050226.3 ENSMUST00000050226.4 ENSMUST00000050226.5 ENSMUST00000050226.6 NM_177776 Q8CI12 SMTL2_MOUSE uc007jyv.1 uc007jyv.2 Belongs to the smoothelin family. molecular_function microtubule organizing center actin cytoskeleton organization filamentous actin uc007jyv.1 uc007jyv.2 
ENSMUST00000050234.4 Jrk ENSMUST00000050234.4 jerky (from RefSeq NM_008415.6) ENSMUST00000050234.1 ENSMUST00000050234.2 ENSMUST00000050234.3 JERKY_MOUSE Jrk NM_008415 Q60976 uc007wfp.1 uc007wfp.2 uc007wfp.3 uc007wfp.4 May bind DNA. Nucleus Brain; highest in the temporal and brainstem regions. Belongs to the tigger transposable element derived protein family. nucleic acid binding DNA binding mRNA binding nucleus cytoplasm positive regulation of canonical Wnt signaling pathway ribonucleoprotein complex ribosome uc007wfp.1 uc007wfp.2 uc007wfp.3 uc007wfp.4 
ENSMUST00000050236.7 Txndc2 ENSMUST00000050236.7 thioredoxin domain containing 2 (spermatozoa), transcript variant 1 (from RefSeq NM_001146002.2) ENSMUST00000050236.1 ENSMUST00000050236.2 ENSMUST00000050236.3 ENSMUST00000050236.4 ENSMUST00000050236.5 ENSMUST00000050236.6 H7BX21 H7BX21_MOUSE NM_001146002 Txndc2 uc008dgf.1 uc008dgf.2 uc008dgf.3 uc008dgf.4 cell cell redox homeostasis uc008dgf.1 uc008dgf.2 uc008dgf.3 uc008dgf.4 
ENSMUST00000050248.9 Zbtb11 ENSMUST00000050248.9 zinc finger and BTB domain containing 11 (from RefSeq NM_173026.2) ENSMUST00000050248.1 ENSMUST00000050248.2 ENSMUST00000050248.3 ENSMUST00000050248.4 ENSMUST00000050248.5 ENSMUST00000050248.6 ENSMUST00000050248.7 ENSMUST00000050248.8 G5E8B9 NM_173026 Q8BZQ5 ZBT11_MOUSE Zbtb11 uc012ago.1 uc012ago.2 uc012ago.3 uc012ago.4 May be involved in transcriptional regulation. Nucleus, nucleolus molecular_function nucleic acid binding nucleoplasm biological_process uc012ago.1 uc012ago.2 uc012ago.3 uc012ago.4 
ENSMUST00000050276.9 Serpinb9h ENSMUST00000050276.9 serine (or cysteine) peptidase inhibitor, clade B, member 9h (from RefSeq NM_001370927.1) ENSMUST00000050276.1 ENSMUST00000050276.2 ENSMUST00000050276.3 ENSMUST00000050276.4 ENSMUST00000050276.5 ENSMUST00000050276.6 ENSMUST00000050276.7 ENSMUST00000050276.8 F6V5V4 F6V5V4_MOUSE Gm11397 NM_001370927 Serpinb9f Serpinb9h uc288lvd.1 uc288lvd.2 Belongs to the serpin family. Ov-serpin subfamily. serine-type endopeptidase inhibitor activity extracellular space cytoplasm negative regulation of endopeptidase activity uc288lvd.1 uc288lvd.2 
ENSMUST00000050306.8 1700056E22Rik ENSMUST00000050306.8 RIKEN cDNA 1700056E22 gene (from RefSeq NM_028516.1) 1700056E22Rik ENSMUST00000050306.1 ENSMUST00000050306.2 ENSMUST00000050306.3 ENSMUST00000050306.4 ENSMUST00000050306.5 ENSMUST00000050306.6 ENSMUST00000050306.7 F7CNM6 F7CNM6_MOUSE NM_028516 uc011wxw.1 uc011wxw.2 uc011wxw.1 uc011wxw.2 
ENSMUST00000050309.6 F830045P16Rik ENSMUST00000050309.6 RIKEN cDNA F830045P16 gene, transcript variant 1 (from RefSeq NM_177653.3) ENSMUST00000050309.1 ENSMUST00000050309.2 ENSMUST00000050309.3 ENSMUST00000050309.4 ENSMUST00000050309.5 F830045P16Rik NM_177653 Q8BJ95 Q8BJ95_MOUSE uc008mhx.1 uc008mhx.2 molecular_function plasma membrane biological_process membrane integral component of membrane uc008mhx.1 uc008mhx.2 
ENSMUST00000050312.3 Mapk8ip1 ENSMUST00000050312.3 mitogen-activated protein kinase 8 interacting protein 1, transcript variant 1 (from RefSeq NM_011162.5) ENSMUST00000050312.1 ENSMUST00000050312.2 Ib1 JIP1_MOUSE Jip1 Mapk8ip NM_011162 O35145 Prkm8ip Q925J8 Q9R1H9 Q9R1Z1 Q9WVI7 Q9WVI8 Q9WVI9 uc008kxx.1 uc008kxx.2 uc008kxx.3 uc008kxx.4 The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response (By similarity). Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells (PubMed:23963642). Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely MAPK8/JNK1, MAPK9/JNK2, MAPK10/JNK3, MAP2K7/MKK7, MAP3K11/MLK3 and DLK1. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2) (By similarity). Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1. Pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Interacts with the cytoplasmic domain of APP (By similarity). Interacts, via the PID domain, with ARHGEF28. Interacts with MAP3K7/TAK1 and VRK2 (By similarity). Interacts with DCLK2 (PubMed:16628014). Found in a complex with SH3RF1, RAC1, MAP3K11/MLK3, MAP2K7/MKK7 and MAPK8/JNK1 (PubMed:23963642). Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and MAPK9/JNK2 (PubMed:27084103). Interacts with SH3RF2 (By similarity). Q9WVI9; Q91ZX7: Lrp1; NbExp=2; IntAct=EBI-74515, EBI-300955; Q9WVI9; A2ARV4: Lrp2; NbExp=2; IntAct=EBI-74515, EBI-300875; Q9WVI9-1; P12023: App; NbExp=3; IntAct=EBI-288461, EBI-78814; Q9WVI9-1; P12023-2: App; NbExp=2; IntAct=EBI-288461, EBI-286828; Q9WVI9-1; Q9JI18: Lrp1b; NbExp=3; IntAct=EBI-288461, EBI-8294317; Q9WVI9-1; P45983: MAPK8; Xeno; NbExp=2; IntAct=EBI-288461, EBI-286483; Q9WVI9-2; Q62073: Map3k7; NbExp=4; IntAct=EBI-288464, EBI-1775345; Q9WVI9-2; Q86Y07-2: VRK2; Xeno; NbExp=2; IntAct=EBI-288464, EBI-1207636; Cytoplasm Cytoplasm, perinuclear region Nucleus Endoplasmic reticulum membrane Mitochondrion membrane Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). Event=Alternative splicing; Named isoforms=5; Name=JIP-1b; IsoId=Q9WVI9-1; Sequence=Displayed; Name=JIP-1a; Synonyms=1; IsoId=Q9WVI9-2; Sequence=VSP_002766; Name=JIP-1c; Synonyms=2a; IsoId=Q9WVI9-3; Sequence=VSP_002763; Name=JIP-1d; Synonyms=2B; IsoId=Q9WVI9-4; Sequence=VSP_002763, VSP_002765; Name=JIP-1e; Synonyms=3; IsoId=Q9WVI9-5; Sequence=VSP_002764; Expressed predominantly in the brain and insulin- secreting cells. In the brain, high expression found in the cerebral cortex and hippocampus. Localizes in the synaptic regions of the olfactory bulb, retina, cerebral and cerebellar cortex and hippocampus. Also expressed in a restricted number of axons, including mossy fibers from the hippocampal dentate gyrus, soma, dendrites and axons of cerebellar Purkinje cells. Also expressed in kidney, testis and prostate. Low levels in heart, ovary and small intestine. Isoform JIP- 1b is more predominant in the brain than isoform JIP-1a. Isoform Jip1-a is expressed both in the brain and kidney, isoform JIP-1c, isoform JIP- 1d and isoform JIP-1e are brain specific. Low levels at prenatal stage 15 dpc, increased levels during the first postnatal days, with a plateau at postnatal day 15. Upon neuron differentiation. The SH3 domain mediates homodimerization. Phosphorylated by MAPK8, MAPK9 and MAPK10. Phosphorylation on Thr- 103 is also necessary for the dissociation and activation of MAP3K12. Phosphorylated by VRK2. Hyperphosphorylated during mitosis following activation of stress-activated and MAP kinases (By similarity). Ubiquitinated. Two preliminary events are required to prime for ubiquitination; phosphorylation and an increased in intracellular calcium concentration. Then, the calcium influx initiates ubiquitination and degradation by the ubiquitin-proteasome pathway. Belongs to the JIP scaffold family. MAP-kinase scaffold activity protein binding nucleus cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane regulation of transcription, DNA-templated receptor-mediated endocytosis signal transduction JUN phosphorylation JUN kinase binding membrane vesicle-mediated transport kinesin binding protein kinase binding axon dendrite mitogen-activated protein kinase kinase binding mitogen-activated protein kinase kinase kinase binding mitochondrial membrane identical protein binding neuron projection negative regulation of apoptotic process negative regulation of JUN kinase activity dendritic growth cone axonal growth cone cell body dentate gyrus mossy fiber synapse positive regulation of endocytosis regulation of JNK cascade negative regulation of JNK cascade positive regulation of JNK cascade perinuclear region of cytoplasm negative regulation of canonical Wnt signaling pathway regulation of CD8-positive, alpha-beta T cell proliferation negative regulation of intrinsic apoptotic signaling pathway uc008kxx.1 uc008kxx.2 uc008kxx.3 uc008kxx.4 
ENSMUST00000050323.6 Rapsn ENSMUST00000050323.6 receptor-associated protein of the synapse, transcript variant 1 (from RefSeq NM_009023.4) ENSMUST00000050323.1 ENSMUST00000050323.2 ENSMUST00000050323.3 ENSMUST00000050323.4 ENSMUST00000050323.5 NM_009023 P12672 Q2M2N6 RAPSN_MOUSE uc008kud.1 uc008kud.2 uc008kud.3 uc008kud.4 Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side. Postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic surface of postsynaptic membranes. A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer. Ubiquitinated by the BCR(KLHL8) complex, leading to its degradation. Belongs to the RAPsyn family. cytoplasm Golgi apparatus centrosome cytosol cytoskeleton plasma membrane chemical synaptic transmission synaptic transmission, cholinergic membrane cell junction neuromuscular junction acetylcholine receptor binding ionotropic glutamate receptor binding protein anchor positive regulation of neuron apoptotic process synapse postsynaptic membrane metal ion binding postsynaptic specialization membrane positive regulation of neuromuscular synaptic transmission regulation of postsynaptic membrane organization establishment of protein localization to postsynaptic membrane uc008kud.1 uc008kud.2 uc008kud.3 uc008kud.4 
ENSMUST00000050325.10 H2-Eb2 ENSMUST00000050325.10 histocompatibility 2, class II antigen E beta2 (from RefSeq NM_001033978.3) CR974457.1-001 ENSMUST00000050325.1 ENSMUST00000050325.2 ENSMUST00000050325.3 ENSMUST00000050325.4 ENSMUST00000050325.5 ENSMUST00000050325.6 ENSMUST00000050325.7 ENSMUST00000050325.8 ENSMUST00000050325.9 H2-Eb2 NM_001033978 Q3UUV9 Q3UUV9_MOUSE uc012apx.1 uc012apx.2 uc012apx.3 uc012apx.4 Membrane ; Single- pass type I membrane protein Belongs to the MHC class II family. adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune response membrane integral component of membrane antigen processing and presentation MHC class II protein complex uc012apx.1 uc012apx.2 uc012apx.3 uc012apx.4 
ENSMUST00000050328.15 Eif2s3x ENSMUST00000050328.15 eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked (from RefSeq NM_012010.3) ENSMUST00000050328.1 ENSMUST00000050328.10 ENSMUST00000050328.11 ENSMUST00000050328.12 ENSMUST00000050328.13 ENSMUST00000050328.14 ENSMUST00000050328.2 ENSMUST00000050328.3 ENSMUST00000050328.4 ENSMUST00000050328.5 ENSMUST00000050328.6 ENSMUST00000050328.7 ENSMUST00000050328.8 ENSMUST00000050328.9 IF2G_MOUSE NM_012010 Q9Z0N1 uc009ttc.1 uc009ttc.2 uc009ttc.3 Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (PubMed:26823431). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.3; Evidence=; Eukaryotic translation initiation factor 2 eIF2 is a heterotrimeric complex composed of an alpha (EIF2S1), a beta (EIF2S2) and a gamma (EIF2S3) chain. eIF2 is member of the 43S pre-initiation complex (43S PIC). Interacts (via C-terminus) with CDC123; the interaction is direct. Cytoplasm, cytosol Widely expressed. In the brain, high mRNA levels are observed in specific regions, including the habenula, anterodorsal thalamic nucleus, hippocampus, hypothalamus, and cerebellum. Also expressed in the embryonic brain. There is a differential expression between males and females, wich is tissue-specific. Females tend to have higher expression levels than males in the brain (cortex, hippocampus and paraventricular nucleus, but not in the habenula), as well as in other tissues. The up-regulation observed in females at the mRNA level may be due to the presence of 2 active copies of the gene. Encoded by an chromosome X-linked gene which escapes inactivation. Has a homolog on chromosome Y (Eif2s3y). Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. nucleotide binding formation of translation preinitiation complex translation initiation factor activity GTPase activity GTP binding cytoplasm cytosol eukaryotic translation initiation factor 2 complex translation translational initiation translation factor activity, RNA binding positive regulation of translational fidelity tRNA binding uc009ttc.1 uc009ttc.2 uc009ttc.3 
ENSMUST00000050342.5 Adam30 ENSMUST00000050342.5 a disintegrin and metallopeptidase domain 30 (from RefSeq NM_027665.2) Adam30 ENSMUST00000050342.1 ENSMUST00000050342.2 ENSMUST00000050342.3 ENSMUST00000050342.4 NM_027665 Q811Q3 Q811Q3_MOUSE uc008qpp.1 uc008qpp.2 uc008qpp.3 uc008qpp.4 Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function metalloendopeptidase activity proteolysis integrin-mediated signaling pathway biological_process metallopeptidase activity external side of plasma membrane membrane integral component of membrane sperm head plasma membrane uc008qpp.1 uc008qpp.2 uc008qpp.3 uc008qpp.4 
ENSMUST00000050372.10 Crb2 ENSMUST00000050372.10 crumbs family member 2, transcript variant 2 (from RefSeq NM_001413709.1) A2ALU1 CRUM2_MOUSE Crb2 ENSMUST00000050372.1 ENSMUST00000050372.2 ENSMUST00000050372.3 ENSMUST00000050372.4 ENSMUST00000050372.5 ENSMUST00000050372.6 ENSMUST00000050372.7 ENSMUST00000050372.8 ENSMUST00000050372.9 NM_001413709 Q6P6N1 Q80YA8 uc008jnf.1 uc008jnf.2 uc008jnf.3 Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo (PubMed:26496195, PubMed:27870829). Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer (PubMed:27870829). The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin- IIB (PubMed:27870829). Also required for maintenance of the apical polarity complex during development of the cortex. Interacts (via intracellular domain) with EPB41L5. Apical cell membrane ingle-pass type I membrane protein Note=O-glucosylation is required for localization at the apical plasma membrane (PubMed:26496195). Distributed in a complex anisotropic pattern on apical cell edges: the level of CRB2 on a cell edge is inversely correlated with the level of MYH10/myosin-IIB (PubMed:27870829). In the adult eye, strongly expressed in the outer nuclear layer, containing the cell bodies of the photoreceptor cells, and in the inner nuclear layer, containing the cell bodies of the horizontal, bipolar, amacrine, and Mueller glial cells (PubMed:15851977). Also expressed in some cells in the ganglion cell layer (or may be displaced amacrine cells rather than ganglion cells) (PubMed:15851977). Expressed in early embryonic cells, more specifically in embryonic regions undergoing dramatic rearrangement, such as the developing neuroepithelium which proceeds with neural tube closure, the anterior splitting lateral plate mesoderm that wraps the pericardial cavity and the differentiating somite epithelium (PubMed:22072575). Widely expressed throughout the epiblast and the lateral plate mesoderm at 7 dpc. At 7.5 dpc-7.75 dpc, continues to be expressed in these regions, and expression is also found on the apical side of the embryonic endoderm, and extraembryonic amnion and allantois (PubMed:22072575). At 8-8.5 dpc, expression is also detected in the heart tube, foregut and the apical side of the somite epithelium (PubMed:22072575). Stronger expression is detected on the apical sides of the splitting lateral plate mesoderm, and the apical side of the neural ectoderm at trunk region (PubMed:22072575). Not expressed in the notochord plate or the extra-embryonic endoderm (PubMed:22072575). Expressed in the developing spinal cord, eye, and forebrain at 10.5 dpc (PubMed:17920587). Expressed in the ventricular layers of the developing neural tube along the entire cranial-caudal length, including the anterior forebrain and the posterior spinal cord at 11.5 dpc (PubMed:17920587). Expressed in apical epithelial kidney cells at 15.5 dpc (PubMed:17920587). O-glucosylated by POGLUT1 at Ser-271; consists of an O-glucose trisaccharide, in which the O-glucose is elongated by the addition of two xylose residues (PubMed:26496195). O-glucosylation is required for localization at the plasma membrane (PubMed:26496195). Embryonic lethality due impaired gastrulation (PubMed:22072575, PubMed:27870829). Mesoderm formation is disrupted, and cells do not ingress (PubMed:27870829). Instead, a single layer forms, and the embryo fails to properly establish its body plan, leading to embryonic arrest (PubMed:27870829). Conditional deletion in the developing retina leads to progressive disorganization during late retinal development: retina show progressive thinning of the photoreceptor layer and sites of cellular mislocalization (PubMed:23001562). Conditional deletion in the dorsal telencephalon leads to defects in the maintenance of the apical complex (PubMed:26802325). Belongs to the Crumbs protein family. mesoderm formation somitogenesis calcium ion binding protein binding plasma membrane heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules multicellular organism development gastrulation regulation of gastrulation positive regulation of epithelial to mesenchymal transition negative regulation of endopeptidase activity notochord formation membrane integral component of membrane apical plasma membrane aspartic-type endopeptidase inhibitor activity positive regulation of BMP signaling pathway macromolecular complex macromolecular complex binding establishment or maintenance of epithelial cell apical/basal polarity maintenance of epithelial cell apical/basal polarity ingression involved in gastrulation with mouth forming second cardiovascular system development uc008jnf.1 uc008jnf.2 uc008jnf.3 
ENSMUST00000050373.7 Tssk6 ENSMUST00000050373.7 testis-specific serine kinase 6 (from RefSeq NM_032004.2) ENSMUST00000050373.1 ENSMUST00000050373.2 ENSMUST00000050373.3 ENSMUST00000050373.4 ENSMUST00000050373.5 ENSMUST00000050373.6 NM_032004 Q5RL09 Q8C625 Q925K9 Sstk TSSK6_MOUSE Tssk6 uc009lye.1 uc009lye.2 uc009lye.3 Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Mg(2+) and Mn(2+) were both present in the kinase buffer but Mg(2+) is likely to be the in vivo cofactor. ; Interacts with HSP90; this interaction stabilizes and activates TSSK6 (PubMed:23599433). Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity (By similarity). Expressed in the testis, localized to the heads of elongating spermatids. Autophosphorylated. Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation. Mice are sterile due to profound impairment in motility and morphology of spermatozoa. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation multicellular organism development spermatogenesis kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation cell differentiation sperm chromatin condensation intracellular signal transduction macromolecular complex binding metal ion binding uc009lye.1 uc009lye.2 uc009lye.3 
ENSMUST00000050383.8 Zfp646 ENSMUST00000050383.8 zinc finger protein 646, transcript variant 1 (from RefSeq NM_172749.4) ENSMUST00000050383.1 ENSMUST00000050383.2 ENSMUST00000050383.3 ENSMUST00000050383.4 ENSMUST00000050383.5 ENSMUST00000050383.6 ENSMUST00000050383.7 NM_172749 Q6NV66 ZN646_MOUSE Zfp646 uc009jxc.1 uc009jxc.2 May be involved in transcriptional regulation. Belongs to the krueppel C2H2-type zinc-finger protein family. RNA polymerase II core promoter sequence-specific DNA binding nucleic acid binding regulation of gene expression metal ion binding nucleus histone methyltransferase complex uc009jxc.1 uc009jxc.2 
ENSMUST00000050385.6 Klri2 ENSMUST00000050385.6 killer cell lectin-like receptor family I member 2 (from RefSeq NM_177155.4) ENSMUST00000050385.1 ENSMUST00000050385.2 ENSMUST00000050385.3 ENSMUST00000050385.4 ENSMUST00000050385.5 KLRI2_MOUSE Klri2 NM_177155 Q5DT36 Q8BS07 uc009egr.1 uc009egr.2 uc009egr.3 Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates NK cell cytolytic activity. Heterodimer with KLRE1. Cell membrane ; Single-pass type II membrane protein Expressed in natural killer (NK) cells. molecular_function plasma membrane integral component of plasma membrane biological_process membrane integral component of membrane carbohydrate binding uc009egr.1 uc009egr.2 uc009egr.3 
ENSMUST00000050389.5 Tmem174 ENSMUST00000050389.5 transmembrane protein 174 (from RefSeq NM_026685.2) ENSMUST00000050389.1 ENSMUST00000050389.2 ENSMUST00000050389.3 ENSMUST00000050389.4 NM_026685 Q96LY0 Q9DCX7 TM174_MOUSE uc011zdk.1 uc011zdk.2 Regulator of plasma phosphate homeostasis. Decreases serum inorganic phosphate (Pi) uptake by regulating the sodium-phosphate cotransporter SLC34A1 trafficking by PTH and FGF23 in the kidney. Interacts with SLC34A1; regulates SLC34A1 internalization by PTH and FGF23. Endoplasmic reticulum membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Note=Colocalizes with SLC34A1 in the plasma membrane of renal proximal tubule cells. Kidney specific (PubMed:35459732, PubMed:35428804). Expressed in renal primary proximal tubule cells (PubMed:35428804). Up-regulated by low-phosphate diet. Tmem174-deficient mice show markedly increased serum levels of Pi, FGF23, and PTH, resulting in vascular calcification. In addition, deficient mice exhibit reduced SLC34A1 responsiveness to FGF23 and PTH administration. A previous study found the localization of TMEM174 in the endoplasmic reticulum (By similarity). A more recent study detected TMEM174 in cell membrane (By similarity). The difference between these two studies could be due to the use of different cell lines. molecular_function cellular_component endoplasmic reticulum endoplasmic reticulum membrane biological_process membrane integral component of membrane uc011zdk.1 uc011zdk.2 
ENSMUST00000050397.2 Sprr2f ENSMUST00000050397.2 small proline-rich protein 2F (from RefSeq NM_011472.3) ENSMUST00000050397.1 NM_011472 O70557 SPR2F_MOUSE uc008qdu.1 uc008qdu.2 Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). Cytoplasm Expressed in uterus. Expression in uterus varies during the estrous cycle, with highest levels during proestrus and estrus stages and declining sharply from metestrus to diestrus. During early pregnancy, uterine expression is markedly increased at 1 dpc, declines rapidly at 2 dpc and is almost undetectable from 3 dpc to 6 dpc. Up-regulated by estrogen in the uterus of ovariectomized animals, with strongly increased expression detected in luminal epithelial and stromal cells at 6 and 12 hours after hormone injection. Belongs to the cornifin (SPRR) family. cornified envelope nucleus cytoplasm epidermis development keratinocyte differentiation keratinization response to estradiol uc008qdu.1 uc008qdu.2 
ENSMUST00000050401.6 She ENSMUST00000050401.6 src homology 2 domain-containing transforming protein E, transcript variant 1 (from RefSeq NM_172530.4) ENSMUST00000050401.1 ENSMUST00000050401.2 ENSMUST00000050401.3 ENSMUST00000050401.4 ENSMUST00000050401.5 NM_172530 Q3TZT0 Q8BSD5 SHE_MOUSE uc008qae.1 uc008qae.2 uc008qae.3 uc008qae.4 Expressed in heart, brain, lung and skeletal muscle. phosphotyrosine binding cellular_component uc008qae.1 uc008qae.2 uc008qae.3 uc008qae.4 
ENSMUST00000050410.11 Swi5 ENSMUST00000050410.11 Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination. (from UniProt A0A0A0MQ99) A0A0A0MQ99 A0A0A0MQ99_MOUSE AK031907 ENSMUST00000050410.1 ENSMUST00000050410.10 ENSMUST00000050410.2 ENSMUST00000050410.3 ENSMUST00000050410.4 ENSMUST00000050410.5 ENSMUST00000050410.6 ENSMUST00000050410.7 ENSMUST00000050410.8 ENSMUST00000050410.9 Swi5 uc289vap.1 uc289vap.2 Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination. Belongs to the SWI5/SAE3 family. uc289vap.1 uc289vap.2 
ENSMUST00000050433.8 Trpc6 ENSMUST00000050433.8 transient receptor potential cation channel, subfamily C, member 6, transcript variant 1 (from RefSeq NM_013838.2) B9EIW2 ENSMUST00000050433.1 ENSMUST00000050433.2 ENSMUST00000050433.3 ENSMUST00000050433.4 ENSMUST00000050433.5 ENSMUST00000050433.6 ENSMUST00000050433.7 NM_013838 Q61143 Q9Z2J1 TRPC6_MOUSE Trp6 Trpc6 Trrp6 uc009odl.1 uc009odl.2 Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Homodimer; forms channel complex. Interacts with MX1 and RNF24. Q61143; Q96D31: ORAI1; Xeno; NbExp=2; IntAct=EBI-15563578, EBI-2291476; Cell membrane ; Multi-pass membrane protein Lung and brain. Phosphorylated by FYN, leading to an increase of TRPC6 channel activity. N-glycosylated. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. actin binding ion channel activity cation channel activity calcium channel activity protein binding cytoplasm plasma membrane integral component of plasma membrane ion transport calcium ion transport manganese ion transport positive regulation of cytosolic calcium ion concentration single fertilization aging positive regulation of peptidyl-threonine phosphorylation store-operated calcium channel activity membrane integral component of membrane neuron differentiation clathrin binding positive regulation of ion transmembrane transporter activity cation channel complex slit diaphragm protein homodimerization activity actinin binding positive regulation of neuron differentiation negative regulation of dendrite morphogenesis ATPase binding regulation of cytosolic calcium ion concentration positive regulation of calcium ion transport transmembrane transport cellular response to hydrogen peroxide calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding cellular response to hypoxia uc009odl.1 uc009odl.2 
ENSMUST00000050434.6 Nyx ENSMUST00000050434.6 nyctalopin (from RefSeq NM_173415.5) ENSMUST00000050434.1 ENSMUST00000050434.2 ENSMUST00000050434.3 ENSMUST00000050434.4 ENSMUST00000050434.5 NM_173415 NYX_MOUSE P83503 Q8BYN4 uc009srn.1 uc009srn.2 Secreted, extracellular space, extracellular matrix Expressed abundantly in retina with lower levels in brain, lung, spleen and testis. Not detected in kidney, heart or liver. In the retina, highest expression found in the inner nuclear layer and ganglion cell layer. Expressed during all stages of postnatal retinal development. Note=Defects in Nyx are the cause of the nob (no b-wave) phenotype which is characterized by a decreased sensitivity to light and an absence of the rod b-wave in electroretinograms. An 85-bp deletion in exon 3 results in the loss of 288 residues from the C- terminus of the protein. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily. extracellular region extracellular space visual perception extracellular matrix response to stimulus uc009srn.1 uc009srn.2 
ENSMUST00000050442.15 Spo11 ENSMUST00000050442.15 SPO11 initiator of meiotic double stranded breaks, transcript variant 1 (from RefSeq NM_012046.3) ENSMUST00000050442.1 ENSMUST00000050442.10 ENSMUST00000050442.11 ENSMUST00000050442.12 ENSMUST00000050442.13 ENSMUST00000050442.14 ENSMUST00000050442.2 ENSMUST00000050442.3 ENSMUST00000050442.4 ENSMUST00000050442.5 ENSMUST00000050442.6 ENSMUST00000050442.7 ENSMUST00000050442.8 ENSMUST00000050442.9 NM_012046 Q8VIH6 Q9QUK2 Q9QY57 Q9QZS1 Q9WTK8 SPO11_MOUSE uc008odd.1 uc008odd.2 uc008odd.3 [Isoform 1]: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed:26917764). The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (PubMed:22346761). [Isoform 4]: In contrast to isoform 1, does not mediate DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; [Isoform 1]: Heterotetramer of SPO11 and 2 TOP6BL chains (Probable). Interacts with TOP6BL (PubMed:26917764). [Isoform 4]: Does not interact with TOP6BL (PubMed:26917764). Q9WTK8-1; J3QMY9: Top6bl; NbExp=6; IntAct=EBI-16201014, EBI-16200997; Nucleus Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Spo11beta , Beta ; IsoId=Q9WTK8-1; Sequence=Displayed; Name=2; IsoId=Q9WTK8-2; Sequence=VSP_007200; Name=3; IsoId=Q9WTK8-3; Sequence=VSP_007197, VSP_007198, VSP_007199; Name=4; Synonyms=Spo11alpha , Alpha ; IsoId=Q9WTK8-4; Sequence=VSP_007197, VSP_007198; Name=5; IsoId=Q9WTK8-5; Sequence=VSP_007197, VSP_007198, VSP_007200; High levels are found only in the testis where expression is restricted primarily to meiotic germ cells. Not expressed in spermatogonia. Highest levels are found in pachytene spermatocytes. Very low levels are found in thymus, brain and oocytes of embryonic ovary. Not detected in adult ovary (PubMed:10622720, PubMed:10855504). Isoform 1: Expressed early in meiosis, when most double-strand breaks (DSB) are formed (PubMed:21330546). Not detected at day 7 postpartum (dpp). Levels are low at 12 dpp but increase by 17 dpp. High levels are maintained throughout the remainder of testis development. Belongs to the TOP6A family. meiotic DNA double-strand break processing DNA catabolic process, endonucleolytic chromosome, telomeric region ovarian follicle development DNA binding catalytic activity protein binding ATP binding nucleus nucleoplasm chromosome DNA metabolic process synapsis synaptonemal complex assembly reciprocal meiotic recombination male meiosis I spermatid development hydrolase activity isomerase activity endodeoxyribonuclease activity, producing 3'-phosphomonoesters protein localization to chromosome meiotic DNA double-strand break formation meiotic telomere clustering metal ion binding oogenesis meiotic cell cycle double-strand break repair involved in meiotic recombination uc008odd.1 uc008odd.2 uc008odd.3 
ENSMUST00000050467.9 Tob2 ENSMUST00000050467.9 transducer of ERBB2, 2 (from RefSeq NM_020507.3) ENSMUST00000050467.1 ENSMUST00000050467.2 ENSMUST00000050467.3 ENSMUST00000050467.4 ENSMUST00000050467.5 ENSMUST00000050467.6 ENSMUST00000050467.7 ENSMUST00000050467.8 NM_020507 Q9JM55 TOB2_MOUSE uc007wxm.1 uc007wxm.2 uc007wxm.3 Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases. Associates with CAF1. Ubiquitous. Belongs to the BTG family. transcription corepressor activity nucleus cytoplasm cytosol negative regulation of cell proliferation regulation of gene expression vitamin D receptor binding negative regulation of osteoclast differentiation positive regulation of ossification negative regulation of nucleic acid-templated transcription uc007wxm.1 uc007wxm.2 uc007wxm.3 
ENSMUST00000050471.4 Pbp2 ENSMUST00000050471.4 phosphatidylethanolamine binding protein 2 (from RefSeq NM_029595.3) E9QLE5 E9QLE5_MOUSE ENSMUST00000050471.1 ENSMUST00000050471.2 ENSMUST00000050471.3 NM_029595 Pbp2 uc009elm.1 uc009elm.2 uc009elm.3 Belongs to the phosphatidylethanolamine-binding protein family. response to organic substance response to organonitrogen compound response to organic cyclic compound uc009elm.1 uc009elm.2 uc009elm.3 
ENSMUST00000050472.16 Uspl1 ENSMUST00000050472.16 ubiquitin specific peptidase like 1, transcript variant 2 (from RefSeq NM_001115149.1) E9QLC6 E9QLC6_MOUSE ENSMUST00000050472.1 ENSMUST00000050472.10 ENSMUST00000050472.11 ENSMUST00000050472.12 ENSMUST00000050472.13 ENSMUST00000050472.14 ENSMUST00000050472.15 ENSMUST00000050472.2 ENSMUST00000050472.3 ENSMUST00000050472.4 ENSMUST00000050472.5 ENSMUST00000050472.6 ENSMUST00000050472.7 ENSMUST00000050472.8 ENSMUST00000050472.9 NM_001115149 Uspl1 uc009aph.1 uc009aph.2 uc009aph.3 cell proliferation snRNA transcription Cajal body protein desumoylation Cajal body organization SUMO binding SUMO-specific isopeptidase activity uc009aph.1 uc009aph.2 uc009aph.3 
ENSMUST00000050476.11 Slc35a4 ENSMUST00000050476.11 solute carrier family 35, member A4, transcript variant 1 (from RefSeq NM_026404.2) ENSMUST00000050476.1 ENSMUST00000050476.10 ENSMUST00000050476.2 ENSMUST00000050476.3 ENSMUST00000050476.4 ENSMUST00000050476.5 ENSMUST00000050476.6 ENSMUST00000050476.7 ENSMUST00000050476.8 ENSMUST00000050476.9 NM_026404 Q8BMH3 Q99JK8 Q9D0A7 Q9D321 S35A4_MOUSE Slc35a4 uc008eob.1 uc008eob.2 uc008eob.3 Mediates the transport of CDP-ribitol (By similarity). Does not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine transport activity (By similarity). Reaction=CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out); Xref=Rhea:RHEA:71579, ChEBI:CHEBI:57608, ChEBI:CHEBI:58069; Evidence=; Found in a complex with SLC35A2 and SLC35A3. Golgi apparatus membrane ; Multi-pass membrane protein Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. Golgi membrane Golgi apparatus carbohydrate transport pyrimidine nucleotide-sugar transmembrane transporter activity membrane integral component of membrane integral component of Golgi membrane positive regulation of translation in response to stress pyrimidine nucleotide-sugar transmembrane transport uc008eob.1 uc008eob.2 uc008eob.3 
ENSMUST00000050480.8 Ccdc66 ENSMUST00000050480.8 Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (By similarity). Plays a role in retina morphogenesis and/or homeostasis (PubMed:21680557). (from UniProt Q6NS45) AK158666 CCD66_MOUSE Ccdc66 ENSMUST00000050480.1 ENSMUST00000050480.2 ENSMUST00000050480.3 ENSMUST00000050480.4 ENSMUST00000050480.5 ENSMUST00000050480.6 ENSMUST00000050480.7 Q3ULU6 Q6NS45 Q8C304 Q8C6T6 uc011zhw.1 uc011zhw.2 uc011zhw.3 uc011zhw.4 uc011zhw.5 Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (By similarity). Plays a role in retina morphogenesis and/or homeostasis (PubMed:21680557). Homodimer; disulfide-linked (Probable). Interacts with CEP290. Interacts with PCM1 (By similarity). Interacts with ARMC9, TOGARAM1, CSPP1 and CEP104 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Photoreceptor inner segment Cell projection, cilium, photoreceptor outer segment Note=Restricted to the centrosomes and the spindle microtubules during mitosis (By similarity). Enriched in the inner segment of the photoreceptor (PubMed:19777273). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6NS45-1; Sequence=Displayed; Name=2; IsoId=Q6NS45-2; Sequence=VSP_031589, VSP_031590; Name=3; IsoId=Q6NS45-3; Sequence=VSP_031588; Widely expressed (PubMed:19777273). Expressed in retina by rod photoreceptors but also detected in outer plexiform and ganglion cell layers (at protein level) (PubMed:21680557, PubMed:19777273). Expressed in the retina from postnatal stages to adulthood. Highest levels are observed at postnatal stage P1 and P4 and expression decreases afterward. Steady levels are observed from P12 to adulthood. Expression increases in the outer segments from P12 to P19 paralleling the differentiation of outer segments. Mice lacking Ccdc66 are viable but display degeneration of the retina. Initial formation of the retina is normal up to postnatal stage P10. Malformation of photoreceptors develops around P13. The degeneration progresses slowly until 3 months after birth, when the outer nuclear layer is reduced to 5-6 rows. From 5 to 7 months, only a thin outer nuclear and photoreceptor layer with severely shrunken outer and inner segments is preserved. It is associated with impaired photoreceptor function with early visual impairment detectable 1 month after birth and progressing slightly until 7 months. Sequence=AAH70471.2; Type=Frameshift; Evidence=; Sequence=AAH72583.1; Type=Miscellaneous discrepancy; Note=Partial nucleotide duplication in position 392 that disrupts the frame.; Evidence=; Sequence=BAC35302.1; Type=Erroneous initiation; Evidence=; Sequence=BAC39936.1; Type=Erroneous initiation; Evidence=; Sequence=BAE34603.1; Type=Erroneous initiation; Evidence=; microtubule bundle formation photoreceptor outer segment retina homeostasis photoreceptor inner segment cytoplasm centrosome microtubule organizing center cytoskeleton microtubule cilium microtubule binding cell projection organization centriolar satellite ciliary basal body protein homodimerization activity cell projection retinal rod cell development detection of light stimulus involved in visual perception post-embryonic retina morphogenesis in camera-type eye cilium assembly regulation of protein localization to cilium uc011zhw.1 uc011zhw.2 uc011zhw.3 uc011zhw.4 uc011zhw.5 
ENSMUST00000050493.4 BB014433 ENSMUST00000050493.4 expressed sequence BB014433 (from RefSeq NR_037972.1) BB014433 ENSMUST00000050493.1 ENSMUST00000050493.2 ENSMUST00000050493.3 NR_037972 Q8C5R5 Q8C5R5_MOUSE uc009kzl.1 uc009kzl.2 uc009kzl.3 uc009kzl.4 molecular_function cellular_component biological_process uc009kzl.1 uc009kzl.2 uc009kzl.3 uc009kzl.4 
ENSMUST00000050497.14 C87436 ENSMUST00000050497.14 expressed sequence C87436, transcript variant 1 (from RefSeq NM_146170.5) CB042_MOUSE ENSMUST00000050497.1 ENSMUST00000050497.10 ENSMUST00000050497.11 ENSMUST00000050497.12 ENSMUST00000050497.13 ENSMUST00000050497.2 ENSMUST00000050497.3 ENSMUST00000050497.4 ENSMUST00000050497.5 ENSMUST00000050497.6 ENSMUST00000050497.7 ENSMUST00000050497.8 ENSMUST00000050497.9 NM_146170 Q3TB16 Q8BK22 Q8BXH4 Q8R2Z4 Q8R3C1 uc009cru.1 uc009cru.2 uc009cru.3 uc009cru.4 uc009cru.5 Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8R3C1-1; Sequence=Displayed; Name=2; IsoId=Q8R3C1-2; Sequence=VSP_027793; Name=3; IsoId=Q8R3C1-3; Sequence=VSP_027792; Name=4; IsoId=Q8R3C1-4; Sequence=VSP_027794, VSP_027795; molecular_function nucleus biological_process nuclear membrane uc009cru.1 uc009cru.2 uc009cru.3 uc009cru.4 uc009cru.5 
ENSMUST00000050516.14 Ascc1 ENSMUST00000050516.14 activating signal cointegrator 1 complex subunit 1, transcript variant 2 (from RefSeq NM_026937.3) ASCC1_MOUSE ENSMUST00000050516.1 ENSMUST00000050516.10 ENSMUST00000050516.11 ENSMUST00000050516.12 ENSMUST00000050516.13 ENSMUST00000050516.2 ENSMUST00000050516.3 ENSMUST00000050516.4 ENSMUST00000050516.5 ENSMUST00000050516.6 ENSMUST00000050516.7 ENSMUST00000050516.8 ENSMUST00000050516.9 NM_026937 Q3TAC2 Q9D8Z1 uc007feh.1 uc007feh.2 uc007feh.3 uc007feh.4 Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. Identified in the ASCC complex that contains ASCC1, ASCC2 and ASCC3. Interacts directly with ASCC3. The ASCC complex interacts with ALKBH3. Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3. Interacts with CSRP1. Interacts with ZCCHC4 (By similarity). Nucleus Nucleus speckle Note=Colocalizes with PRPF8 in nuclear speckles in the absence of DNA damage. Expressed in the spinal cord, brain, paraspinal ganglia, thyroid, and submandibular glands. Expressed in 17.5-day-old embryos. nucleic acid binding RNA binding nucleus transcription factor complex DNA repair regulation of transcription, DNA-templated cellular response to DNA damage stimulus nuclear speck neuromuscular junction uc007feh.1 uc007feh.2 uc007feh.3 uc007feh.4 
ENSMUST00000050519.8 Elfn1 ENSMUST00000050519.8 leucine rich repeat and fibronectin type III, extracellular 1, transcript variant 1 (from RefSeq NM_175522.4) ELFN1_MOUSE ENSMUST00000050519.1 ENSMUST00000050519.2 ENSMUST00000050519.3 ENSMUST00000050519.4 ENSMUST00000050519.5 ENSMUST00000050519.6 ENSMUST00000050519.7 NM_175522 Ppp1r28 Q8C8T7 uc009ahi.1 uc009ahi.2 uc009ahi.3 uc009ahi.4 uc009ahi.5 Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses. Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Interacts with PPP1CA. Membrane ; Single-pass type I membrane protein Cell projection, dendrite Note=Localizes to excitatory synapses onto somatostatin (Sst)-containing oriens-lacunosum moleculare (O-LM) interneurons. Selectively expressed in perialvear somatostatin (Sst)-containing interneurons. protein phosphatase inhibitor activity extracellular space negative regulation of phosphatase activity membrane integral component of membrane dendrite extracellular matrix negative regulation of phosphoprotein phosphatase activity cell projection synapse organization excitatory synapse uc009ahi.1 uc009ahi.2 uc009ahi.3 uc009ahi.4 uc009ahi.5 
ENSMUST00000050536.14 Cmklr2 ENSMUST00000050536.14 chemerin chemokine-like receptor 2, transcript variant 1 (from RefSeq NM_146250.3) CML2_MOUSE ENSMUST00000050536.1 ENSMUST00000050536.10 ENSMUST00000050536.11 ENSMUST00000050536.12 ENSMUST00000050536.13 ENSMUST00000050536.2 ENSMUST00000050536.3 ENSMUST00000050536.4 ENSMUST00000050536.5 ENSMUST00000050536.6 ENSMUST00000050536.7 ENSMUST00000050536.8 ENSMUST00000050536.9 Gpr1 NM_146250 Q8K087 uc007bga.1 uc007bga.2 uc007bga.3 uc007bga.4 uc007bga.5 Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:24895415). Signals mainly via beta- arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem- cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (PubMed:29799787). Cell membrane ; Multi-pass membrane protein Note=Internalizes in presence of its ligand, TAFA1 (PubMed:29799787). Internalizes efficiently in response to RARRES2 (By similarity). High expressed in white adipose tissue and skeletal muscle (PubMed:24895415). Expressed in hippocampus and cortex (PubMed:29799787). Deficient mice have normal body weight, adipose development, and tissue inflammation under physiologic conditions. However, when fed on a high-fat diet, Cmklr2 knockout mice develop heightened glucose intolerance, compared with WT, with no effect on body weight, percent body fat, or energy expenditure due to consumption of significantly less food. Moreover, mice lacking Cmklr2 exhibited reduced glucose-stimulated insulin levels and elevated glucose levels in a pyruvate tolerance test. Belongs to the chemokine-like receptor (CMKLR) family. G-protein coupled receptor activity nucleoplasm plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway membrane integral component of membrane peptide binding neuropeptide binding intracellular membrane-bounded organelle uc007bga.1 uc007bga.2 uc007bga.3 uc007bga.4 uc007bga.5 
ENSMUST00000050544.8 Has2 ENSMUST00000050544.8 hyaluronan synthase 2 (from RefSeq NM_008216.3) ENSMUST00000050544.1 ENSMUST00000050544.2 ENSMUST00000050544.3 ENSMUST00000050544.4 ENSMUST00000050544.5 ENSMUST00000050544.6 ENSMUST00000050544.7 HYAS2_MOUSE Has2 NM_008216 P70312 P70411 Q62405 Q68EF7 uc007vsl.1 uc007vsl.2 uc007vsl.3 uc007vsl.4 Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan (PubMed:10455188). Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development (PubMed:10930438). May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix. Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (By similarity). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (PubMed:10455188). Reaction=[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N- acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP; Xref=Rhea:RHEA:20465, Rhea:RHEA-COMP:12583, Rhea:RHEA-COMP:12585, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:132153, ChEBI:CHEBI:132154; EC=2.4.1.212; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20466; Evidence=; Reaction=N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP- alpha-D-glucuronate = [hyaluronan](n+1) + H(+) + UDP; Xref=Rhea:RHEA:12528, Rhea:RHEA-COMP:12585, Rhea:RHEA-COMP:12587, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132153, ChEBI:CHEBI:132154; EC=2.4.1.212; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12529; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Kinetic parameters: KM=0.2 mM for UDP-Glc-NAc (at pH 7.1 and 37 degrees Celsius, in the presence of 15 mM MgCl2) ; KM=0.3 mM for UDP-Glc-UA (at pH 7.1 and 37 degrees Celsius, in the presence of 15 mM MgCl2) ; Glycan biosynthesis; hyaluronan biosynthesis. Homodimer; dimerization promotes enzymatic activity. Forms heterodimer with HAS3. Forms heterodimer with HAS1. Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Vesicle Golgi apparatus membrane ; Multi-pass membrane protein Lysosome Note=Travels from endoplasmic reticulum (ER), Golgi to plasma membrane and either back to endosomes and lysosomes, or out into extracellular vesicles. Post-translational modifications control HAS2 trafficking. Expressed in heart, brain, spleen, lung and skeletal muscle. Detected from 7.5 dpc through birth. At 8.5 dpc, predominantly expressed in the epithelium of the foregut diverticulum, the cephalic mesenchyme, the allantois, and in the myocardium and endocardium of the heart. At 9.5 dpc, prominent expression is detected in cephalic, foregut and periaortic mesenchymes, the septum transversum and the cardiovascular system. Also present in the atrial and ventricular endothelium and the myocardium of the atrioventricular canal region. By 10.5 dpc, highly expressed in endothelial cells in the atrioventricular canal and outflow tract that transform into mesenchymal cells and invade the underlying matrix. Later, expressed by mesenchymal cells during elevation of the secondary palate and by hypertrophic chondrocytes within epiphysial growth plates. Phosphorylation at Thr-328 is essential for hyaluronan synthase activity. O-GlcNAcylation at Ser-221 increases the stability of HAS2 and plasma membrane localization. Ubiquitination at Lys-190; this ubiquitination is essential for hyaluronan synthase activity and homo- or hetero-oligomerization. Can also be poly-ubiquitinated. Deubiquitinated by USP17L22/USP17 and USP4. USP17L22/USP17 efficiently removes 'Lys-63'- and 'Lys-48'-linked polyubiquitin chains, whereas USP4 preferentially removes monoubiquitination and, partially, both 'Lys-63'- and 'Lys-48'-linked polyubiquitin chain. Embryonic lethal. At day 9.5 dpc, the distribution of homozygous embryos approaches Mendelian frequency while only occasional viable embryos were found at 10.5 dpc. Embryos exhibited growth retardation, scant numbers of red blood cells, and lacked vitelline vessels in the yolk sac. The visceral endoderm and mesoderm forming the yolk sac was not fused except at discrete foci. The heart was thinwalled and relatively bloodless, and often exhibited marked pericardial swelling. The heart lacks cardiac jelly, endocardial cushions and trabeculae. A marked reduction in vessels in homozygous embryos is also observed. Somites were present but distorted. Some of the 9.5 dpc embryos had failed to turn, and exhibited posterior defects as well as cephalic mesenchyme abnormalities. Belongs to the NodC/HAS family. Name=Protein Spotlight; Note=an unexpected turn of events - Issue 155 of December 2013; URL="https://web.expasy.org/spotlight/back_issues/155/"; vasculogenesis kidney development cytoplasm integral component of plasma membrane positive regulation of cell proliferation positive regulation of keratinocyte proliferation positive regulation of smooth muscle cell migration membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups hyaluronan metabolic process hyaluronan biosynthetic process positive regulation of cell migration positive regulation of urine volume cellular response to platelet-derived growth factor stimulus atrioventricular canal development identical protein binding estrous cycle plasma membrane raft extracellular polysaccharide biosynthetic process hyaluronan synthase activity positive regulation of keratinocyte migration bone morphogenesis renal water absorption cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to fluid shear stress extracellular matrix assembly endocardial cushion to mesenchymal transition positive regulation of substrate adhesion-dependent cell spreading positive regulation of hyaluronan biosynthetic process positive regulation of monocyte aggregation regulation of extracellular matrix assembly uc007vsl.1 uc007vsl.2 uc007vsl.3 uc007vsl.4 
ENSMUST00000050551.10 Cited1 ENSMUST00000050551.10 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1, transcript variant 3 (from RefSeq NM_001276473.1) Cited1 ENSMUST00000050551.1 ENSMUST00000050551.2 ENSMUST00000050551.3 ENSMUST00000050551.4 ENSMUST00000050551.5 ENSMUST00000050551.6 ENSMUST00000050551.7 ENSMUST00000050551.8 ENSMUST00000050551.9 NM_001276473 Q3UGA1 Q3UGA1_MOUSE uc009tyo.1 uc009tyo.2 uc009tyo.3 uc009tyo.4 uc009tyo.5 Nucleus Belongs to the CITED family. embryonic axis specification branching involved in ureteric bud morphogenesis negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis transcription coactivator activity nucleus cytoplasm cytosol regulation of transcription, DNA-templated nucleocytoplasmic transport transforming growth factor beta receptor signaling pathway protein C-terminus binding melanocyte differentiation protein homodimerization activity regulation of apoptotic process pigmentation negative regulation of neuron apoptotic process response to estrogen transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated LBD domain binding SMAD protein signal transduction co-SMAD binding response to transforming growth factor beta uc009tyo.1 uc009tyo.2 uc009tyo.3 uc009tyo.4 uc009tyo.5 
ENSMUST00000050552.15 Bzw1 ENSMUST00000050552.15 basic leucine zipper and W2 domains 1 (from RefSeq NM_025824.4) 5MP2_MOUSE 5mp2 ENSMUST00000050552.1 ENSMUST00000050552.10 ENSMUST00000050552.11 ENSMUST00000050552.12 ENSMUST00000050552.13 ENSMUST00000050552.14 ENSMUST00000050552.2 ENSMUST00000050552.3 ENSMUST00000050552.4 ENSMUST00000050552.5 ENSMUST00000050552.6 ENSMUST00000050552.7 ENSMUST00000050552.8 ENSMUST00000050552.9 NM_025824 Q3THS5 Q3UZ94 Q9CQC6 uc007bbr.1 uc007bbr.2 uc007bbr.3 Translation initiation regulator which represses repeat- associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (By similarity). Enhances histone H4 gene transcription but does not seem to bind DNA directly (By similarity). Broadly expressed, with highest levels in testis. Belongs to the BZW family. cytoplasm uc007bbr.1 uc007bbr.2 uc007bbr.3 
ENSMUST00000050556.11 Bod1l ENSMUST00000050556.11 biorientation of chromosomes in cell division 1-like, transcript variant 1 (from RefSeq NM_001081422.3) BD1L1_MOUSE Bod1l E9Q6J5 ENSMUST00000050556.1 ENSMUST00000050556.10 ENSMUST00000050556.2 ENSMUST00000050556.3 ENSMUST00000050556.4 ENSMUST00000050556.5 ENSMUST00000050556.6 ENSMUST00000050556.7 ENSMUST00000050556.8 ENSMUST00000050556.9 Kiaa1327 NM_001081422 O35243 Q3TR39 Q3USW6 Q80TF0 Q8BHG7 uc008xhe.1 uc008xhe.2 uc008xhe.3 uc008xhe.4 uc008xhe.5 Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation. Interacts (via COMPASS-Shg1 domain) with SETD1A at stalled replication forks; this interaction mediates FANCD2-dependent nucleosome remodeling at reversed forks protecting them from nucleolytic degradation. Chromosome Note=Localizes at replication forks: following DNA damage, localizes to damaged replication forks undergoing resection. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=E9Q6J5-1; Sequence=Displayed; Name=2; IsoId=E9Q6J5-2; Sequence=VSP_057903; Name=3; IsoId=E9Q6J5-3; Sequence=VSP_057902; Belongs to the BOD1 family. Sequence=AAB69856.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE24214.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE37191.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; spindle pole condensed chromosome outer kinetochore DNA binding protein phosphatase inhibitor activity nucleoplasm chromosome centrosome spindle microtubule DNA repair cellular response to DNA damage stimulus replication fork processing negative regulation of phosphoprotein phosphatase activity protein phosphatase 2A binding uc008xhe.1 uc008xhe.2 uc008xhe.3 uc008xhe.4 uc008xhe.5 
ENSMUST00000050561.13 Mau2 ENSMUST00000050561.13 MAU2 sister chromatid cohesion factor, transcript variant 7 (from RefSeq NR_165036.1) B7ZN38 ENSMUST00000050561.1 ENSMUST00000050561.10 ENSMUST00000050561.11 ENSMUST00000050561.12 ENSMUST00000050561.2 ENSMUST00000050561.3 ENSMUST00000050561.4 ENSMUST00000050561.5 ENSMUST00000050561.6 ENSMUST00000050561.7 ENSMUST00000050561.8 ENSMUST00000050561.9 Kiaa0892 NR_165036 Q059Q4 Q5DU12 Q78IR4 Q8BUW9 Q8BX04 Q9D2X5 SCC4_MOUSE Scc4 uc009lyk.1 uc009lyk.2 uc009lyk.3 Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodim. eric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin Plays a role in sister chromatid cohesion and normal progression through prometaphase. Heterodimerizes with MAU2/SCC2 to form the cohesin loading complex. The NIPBL-MAU2 heterodimer interacts with the SMC1A-SMC3 heterodimer and with the cohesin complex composed of SMC1A, SMC3, RAD21 and STAG1. Nucleus, nucleoplasm Chromosome Nucleus Note=Binds to chromatin from the end of mitosis until prophase. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D2X5-1; Sequence=Displayed; Name=2; IsoId=Q9D2X5-2; Sequence=VSP_037924; Spermatocytes and oocytes (at protein level). Belongs to the SCC4/mau-2 family. Sequence=AAH23401.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; chromatin double-stranded DNA binding nucleus nucleoplasm chromosome cell cycle chromosome segregation mitotic sister chromatid cohesion nuclear body SMC loading complex maintenance of mitotic sister chromatid cohesion protein N-terminus binding cell division cohesin loading Scc2-Scc4 cohesin loading complex uc009lyk.1 uc009lyk.2 uc009lyk.3 
ENSMUST00000050562.6 Ch25h ENSMUST00000050562.6 cholesterol 25-hydroxylase (from RefSeq NM_009890.2) CH25H_MOUSE Ch25h ENSMUST00000050562.1 ENSMUST00000050562.2 ENSMUST00000050562.3 ENSMUST00000050562.4 ENSMUST00000050562.5 NM_009890 Q3TUM6 Q8CHQ2 Q9Z0F5 uc008hgj.1 uc008hgj.2 uc008hgj.3 uc008hgj.4 uc008hgj.5 Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097, PubMed:29033131). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7- alpha,25-OHC), an oxysterol that acts as a ligand for the G protein- coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (PubMed:22999953). May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing (PubMed:9852097). In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation (PubMed:9852097). Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (PubMed:29033131). Interferon-stimulated gene which has broad antiviral activities against a wide range of enveloped viruses (By similarity). Reaction=AH2 + cholesterol + O2 = 25-hydroxycholesterol + A + H2O; Xref=Rhea:RHEA:21104, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:17499, ChEBI:CHEBI:42977; EC=1.14.99.38; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21105; Evidence=; Reaction=cholesterol + H(+) + NADPH + O2 = 25-hydroxycholesterol + H2O + NADP(+); Xref=Rhea:RHEA:46132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:42977, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46133; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Widely expressed at low level and at higher level in the lung. Weakly expressed in the heart, lung and kidney. N-glycosylated. Mice do not display any apparent alteration in bile acid synthesis and cholesterol metabolism (PubMed:12543708). Macrophages however display impaired mitochondrial metabolism, due to increased cholesterol that triggers cytosolic mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (PubMed:29033131). Belongs to the sterol desaturase family. C-4 methylsterol oxidase activity cholesterol 25-hydroxylase activity monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process steroid metabolic process cholesterol metabolic process steroid hydroxylase activity lipid biosynthetic process membrane integral component of membrane sterol biosynthetic process oxidoreductase activity B cell chemotaxis metal ion binding oxidation-reduction process uc008hgj.1 uc008hgj.2 uc008hgj.3 uc008hgj.4 uc008hgj.5 
ENSMUST00000050574.7 Ccnjl ENSMUST00000050574.7 cyclin J-like (from RefSeq NM_001045530.2) B2RTH5 CCNJL_MOUSE ENSMUST00000050574.1 ENSMUST00000050574.2 ENSMUST00000050574.3 ENSMUST00000050574.4 ENSMUST00000050574.5 ENSMUST00000050574.6 Gm877 NM_001045530 Q5SRT8 uc007ims.1 uc007ims.2 uc007ims.3 uc007ims.4 Belongs to the cyclin family. Cyclin J subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein kinase holoenzyme complex nucleus cytoplasm protein phosphorylation cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding mitotic cell cycle phase transition protein kinase activity uc007ims.1 uc007ims.2 uc007ims.3 uc007ims.4 
ENSMUST00000050575.9 Thtpa ENSMUST00000050575.9 thiamine triphosphatase (from RefSeq NM_153083.5) ENSMUST00000050575.1 ENSMUST00000050575.2 ENSMUST00000050575.3 ENSMUST00000050575.4 ENSMUST00000050575.5 ENSMUST00000050575.6 ENSMUST00000050575.7 ENSMUST00000050575.8 NM_153083 Q3V1G2 Q8C3P9 Q8JZL3 THTPA_MOUSE uc007tyb.1 uc007tyb.2 uc007tyb.3 uc007tyb.4 This gene encodes a cytosolic enzyme that catalyzes the conversion of thiamine triphosphate to thiamine diphosphate. The encoded protein requires divalent cations for enzymatic activity. The gene product is believed to play a role in regulation of thiamine triphosphate intracellular concentration, and it may be a messenger in cell signaling in response to cellular stress. [provided by RefSeq, Mar 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF432864.2, SRR1660811.186522.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Hydrolase highly specific for thiamine triphosphate (ThTP). Reaction=H2O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate; Xref=Rhea:RHEA:11744, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58937, ChEBI:CHEBI:58938; EC=3.6.1.28; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; pH dependence: Optimum pH is 7.5-9.5. ; Monomer. Cytoplasm Belongs to the ThTPase family. magnesium ion binding cytoplasm thiamine metabolic process dephosphorylation hydrolase activity thiamine diphosphate metabolic process metal ion binding thiamin-triphosphatase activity uc007tyb.1 uc007tyb.2 uc007tyb.3 uc007tyb.4 
ENSMUST00000050581.5 ENSMUSG00000121653 ENSMUST00000050581.5 ENSMUSG00000121653 (from geneSymbol) BC064681 ENSMUST00000050581.1 ENSMUST00000050581.2 ENSMUST00000050581.3 ENSMUST00000050581.4 uc287oki.1 uc287oki.2 uc287oki.3 uc287oki.1 uc287oki.2 uc287oki.3 
ENSMUST00000050585.7 Or6ae1 ENSMUST00000050585.7 olfactory receptor family 6 subfamily AE member 1 (from RefSeq NM_146952.1) ENSMUST00000050585.1 ENSMUST00000050585.2 ENSMUST00000050585.3 ENSMUST00000050585.4 ENSMUST00000050585.5 ENSMUST00000050585.6 NM_146952 Olfr522 Or6ae1 Q8VGL1 Q8VGL1_MOUSE uc009khf.1 uc009khf.2 uc009khf.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009khf.1 uc009khf.2 uc009khf.3 
ENSMUST00000050611.14 Cep68 ENSMUST00000050611.14 centrosomal protein 68 (from RefSeq NM_172260.3) CEP68_MOUSE ENSMUST00000050611.1 ENSMUST00000050611.10 ENSMUST00000050611.11 ENSMUST00000050611.12 ENSMUST00000050611.13 ENSMUST00000050611.2 ENSMUST00000050611.3 ENSMUST00000050611.4 ENSMUST00000050611.5 ENSMUST00000050611.6 ENSMUST00000050611.7 ENSMUST00000050611.8 ENSMUST00000050611.9 NM_172260 Q3US49 Q5SW85 Q8C0D9 Q8R2V0 uc007icw.1 uc007icw.2 uc007icw.3 Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. Contributes to CROCC/rootletin filament formation. Interacts with CNTLN; the interaction recruits CEP68 to the centrosome. Interacts with the SCF(FBXW11) complex which contains SKP1, CUL1 and FBXW11; the interaction is probably mediated by FBXW11 and the complex also contains CDK5RAP2 and PCNT. Also interacts with F-box protein BTRC. Interacts with serine/threonine-protein kinase PLK1; the interaction leads to phosphorylation of CEP68 and its subsequent degradation. Interacts with NEK2; the interaction leads to phosphorylation of CEP68. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to thin fibers protruding away from the proximal ends of the two centrioles. Dissociates from interphase centrosomes at the onset of mitosis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C0D9-1; Sequence=Displayed; Name=2; IsoId=Q8C0D9-2; Sequence=VSP_013477; Phosphorylation by PLK1 is required for binding to BTRC in prometaphase. Phosphorylated directly or indirectly by NEK2. NEK2- mediated phosphorylation promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis. Ubiquitinated and targeted for proteasomal degradation in early mitosis by the SCF(BTRC) and/or SCF(FBXW11) E3 ubiquitin-protein ligase complexes. Degradation is complete by prometaphase and is required for removal of CDK5RAP2 from the peripheral pericentriolar material and subsequent centriole separation. nucleus cytoplasm centrosome microtubule organizing center cytosol cytoskeleton centrosome cycle centriole-centriole cohesion protein kinase binding protein domain specific binding cell junction protein localization to organelle uc007icw.1 uc007icw.2 uc007icw.3 
ENSMUST00000050625.15 Sema5b ENSMUST00000050625.15 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B (from RefSeq NM_013661.3) B1B1A9 ENSMUST00000050625.1 ENSMUST00000050625.10 ENSMUST00000050625.11 ENSMUST00000050625.12 ENSMUST00000050625.13 ENSMUST00000050625.14 ENSMUST00000050625.2 ENSMUST00000050625.3 ENSMUST00000050625.4 ENSMUST00000050625.5 ENSMUST00000050625.6 ENSMUST00000050625.7 ENSMUST00000050625.8 ENSMUST00000050625.9 Kiaa1445 NM_013661 Q60519 Q6ZPQ8 Q7TT33 Q8BVE5 SEM5B_MOUSE SemG Semag uc007zbm.1 uc007zbm.2 uc007zbm.3 uc007zbm.4 May act as a positive axonal guidance cue. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q60519-1; Sequence=Displayed; Name=2; IsoId=Q60519-2; Sequence=VSP_029467, VSP_029468; Name=3; IsoId=Q60519-3; Sequence=VSP_029466; In adult, only detected in brain. Differentially expressed in embryonic and adult tissues (PubMed:8817451). Its abundance decreases from 10 dpc to birth (PubMed:8817451). Belongs to the semaphorin family. multicellular organism development nervous system development membrane integral component of membrane cell differentiation semaphorin receptor binding axon extension detection of light stimulus involved in visual perception neuron projection guidance neuron projection extension uc007zbm.1 uc007zbm.2 uc007zbm.3 uc007zbm.4 
ENSMUST00000050630.14 Supt3 ENSMUST00000050630.14 SPT3, SAGA and STAGA complex component, transcript variant 2 (from RefSeq NR_158206.1) ENSMUST00000050630.1 ENSMUST00000050630.10 ENSMUST00000050630.11 ENSMUST00000050630.12 ENSMUST00000050630.13 ENSMUST00000050630.2 ENSMUST00000050630.3 ENSMUST00000050630.4 ENSMUST00000050630.5 ENSMUST00000050630.6 ENSMUST00000050630.7 ENSMUST00000050630.8 ENSMUST00000050630.9 NR_158206 Q8BVY4 Q8BVY4_MOUSE Supt3 Supt3h uc008cqf.1 uc008cqf.2 uc008cqf.3 DNA binding transcription cofactor activity transcription coactivator activity histone acetyltransferase activity nucleus nucleoplasm transcription factor TFIID complex regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter histone deubiquitination STAGA complex transcription factor TFTC complex histone H3 acetylation protein heterodimerization activity positive regulation of nucleic acid-templated transcription uc008cqf.1 uc008cqf.2 uc008cqf.3 
ENSMUST00000050646.13 Ttc19 ENSMUST00000050646.13 tetratricopeptide repeat domain 19, transcript variant 1 (from RefSeq NM_028360.3) ENSMUST00000050646.1 ENSMUST00000050646.10 ENSMUST00000050646.11 ENSMUST00000050646.12 ENSMUST00000050646.2 ENSMUST00000050646.3 ENSMUST00000050646.4 ENSMUST00000050646.5 ENSMUST00000050646.6 ENSMUST00000050646.7 ENSMUST00000050646.8 ENSMUST00000050646.9 NM_028360 Q5NCZ3 Q5NCZ4 Q8CC21 Q8K1X2 Q8R0G6 Q9CYS5 TTC19_MOUSE uc007jir.1 uc007jir.2 uc007jir.3 uc007jir.4 Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1 (PubMed:21278747, PubMed:28673544). Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation into the complex III and whose presence is detrimental for its catalytic activity (PubMed:28673544). Binds to the mature mitochondrial complex III dimer, after the incorporation of the Rieske protein UQCRFS1 (PubMed:28673544, PubMed:21278747). Interacts with UQCRC1 and UQCRFS1 (PubMed:21278747). Interacts with ZFYVE26 and CHMP4B (By similarity). Mitochondrion inner membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CC21-1; Sequence=Displayed; Name=2; IsoId=Q8CC21-2; Sequence=VSP_041051; Proteolytically cleaved by PARL. Mutant mice show progressive neurological and energy metabolic decline, decrease complex III activity, increased production of reactive oxygen species, extensive astrogliosis and accumulation of ubiquitinated proteins in neurons of the thalamus. Compatible with a Mendelian autosomal recessive trait. No evidence of embryonic lethality nor evidence of obvious neuronal loss. Belongs to the TTC19 family. Sequence=AAH37111.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB28813.2; Type=Frameshift; Evidence=; Sequence=EDL10340.1; Type=Erroneous gene model prediction; Evidence=; protein binding mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain complex III assembly oxidation-reduction process respiratory chain uc007jir.1 uc007jir.2 uc007jir.3 uc007jir.4 
ENSMUST00000050649.6 Gpr135 ENSMUST00000050649.6 G protein-coupled receptor 135 (from RefSeq NM_181752.2) ENSMUST00000050649.1 ENSMUST00000050649.2 ENSMUST00000050649.3 ENSMUST00000050649.4 ENSMUST00000050649.5 GP135_MOUSE NM_181752 Q7TQP2 uc007nvc.1 uc007nvc.2 uc007nvc.3 Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). Interacts with MTNR1B. Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR135 in the endosomal compartment (By similarity). Cell membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Note=Colocalizes with ARRB2/beta-arrestin-2 in the endosome (By similarity). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity endosome plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process endosome membrane membrane integral component of membrane arrestin family protein binding uc007nvc.1 uc007nvc.2 uc007nvc.3 
ENSMUST00000050658.6 Spz1 ENSMUST00000050658.6 spermatogenic leucine zipper 1 (from RefSeq NM_030237.3) ENSMUST00000050658.1 ENSMUST00000050658.2 ENSMUST00000050658.3 ENSMUST00000050658.4 ENSMUST00000050658.5 NM_030237 Q3V487 Q80X69 Q99MY0 SPZ1_MOUSE uc007rkr.1 uc007rkr.2 uc007rkr.3 uc007rkr.4 uc007rkr.5 Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine-rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis. Interacts with PPP1CC isoform gamma-2. This interaction can prevent SPZ1 binding to the E-box and inhibits PPP1CC activity. Cytoplasm Nucleus Expressed specifically in the testis and epidydimis. In the testis expressed in both germ cells and somatic cells (Sertoli and Leydig cells). Expressed in several tumor cell lines. First detected in the testis at postnatal day 10 and levels increase further and reach highest levels at day 40 and then gradually decrease. Down-regulated by testosterone and retinoic acid. Phosphorylated by MAPK1/ERK2 and MAPK3/ERK1. The helix-loop-helix and basic motifs form a Spz1 specific bHLH different from the classical one. DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated uc007rkr.1 uc007rkr.2 uc007rkr.3 uc007rkr.4 uc007rkr.5 
ENSMUST00000050660.6 Teddm1a ENSMUST00000050660.6 transmembrane epididymal protein 1A (from RefSeq NM_178244.4) E9QLK8 E9QLK8_MOUSE ENSMUST00000050660.1 ENSMUST00000050660.2 ENSMUST00000050660.3 ENSMUST00000050660.4 ENSMUST00000050660.5 NM_178244 Teddm1 Teddm1a uc007dap.1 uc007dap.2 uc007dap.3 uc007dap.4 Membrane ; Multi- pass membrane protein Belongs to the TMEM45 family. membrane integral component of membrane uc007dap.1 uc007dap.2 uc007dap.3 uc007dap.4 
ENSMUST00000050668.4 Zfp770 ENSMUST00000050668.4 zinc finger protein 770 (from RefSeq NM_175466.5) ENSMUST00000050668.1 ENSMUST00000050668.2 ENSMUST00000050668.3 NM_175466 Q3TPP6 Q8BIQ8 Q8BK15 Q8BLQ1 ZN770_MOUSE Znf770 uc008lqj.1 uc008lqj.2 uc008lqj.3 uc008lqj.4 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus metal ion binding uc008lqj.1 uc008lqj.2 uc008lqj.3 uc008lqj.4 
ENSMUST00000050702.9 Ptprq ENSMUST00000050702.9 protein tyrosine phosphatase receptor type Q, transcript variant 1 (from RefSeq NM_001370987.1) ENSMUST00000050702.1 ENSMUST00000050702.2 ENSMUST00000050702.3 ENSMUST00000050702.4 ENSMUST00000050702.5 ENSMUST00000050702.6 ENSMUST00000050702.7 ENSMUST00000050702.8 NM_001370987 P0C5E4 PTPRQ_MOUSE uc007gzb.1 uc007gzb.2 uc007gzb.3 Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5- bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Membrane ; Single-pass type I membrane protein In the inner ear of the early postnatal mouse, it is present in hair bundles in the cochlea and in the vestibule. Restricted to the hair bundles and not detected in any other cell type within the inner ear. Restricted to the basal region of the hair bundle (at protein level). Mice show rapid postnatal deterioration in cochlear hair-bundle structure, associated with smaller than normal transducer currents with otherwise normal adaptation properties, a progressive loss of basal-coil cochlear hair cells, and deafness. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. hematopoietic progenitor cell differentiation phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein dephosphorylation membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity stereocilium bundle peptidyl-tyrosine dephosphorylation inner ear morphogenesis regulation of fat cell differentiation neuromuscular process controlling balance detection of mechanical stimulus involved in sensory perception of sound vestibular receptor cell morphogenesis uc007gzb.1 uc007gzb.2 uc007gzb.3 
ENSMUST00000050707.3 Vsig4 ENSMUST00000050707.3 V-set and immunoglobulin domain containing 4 (from RefSeq NM_177789.5) ENSMUST00000050707.1 ENSMUST00000050707.2 F6TUL9 F6TUL9_MOUSE NM_177789 Vsig4 uc009tui.1 uc009tui.2 complement component C3b binding membrane integral component of membrane negative regulation of interleukin-2 production macromolecular complex negative regulation of T cell proliferation negative regulation of macrophage activation negative regulation of complement activation, alternative pathway uc009tui.1 uc009tui.2 
ENSMUST00000050714.8 Igfals ENSMUST00000050714.8 insulin-like growth factor binding protein, acid labile subunit, transcript variant 1 (from RefSeq NM_008340.4) A0A0R4J0S2 A0A0R4J0S2_MOUSE ENSMUST00000050714.1 ENSMUST00000050714.2 ENSMUST00000050714.3 ENSMUST00000050714.4 ENSMUST00000050714.5 ENSMUST00000050714.6 ENSMUST00000050714.7 Igfals NM_008340 uc008ayn.1 uc008ayn.2 uc008ayn.3 nucleoplasm insulin-like growth factor ternary complex uc008ayn.1 uc008ayn.2 uc008ayn.3 
ENSMUST00000050735.12 Zfp260 ENSMUST00000050735.12 zinc finger protein 260 (from RefSeq NM_011981.4) ENSMUST00000050735.1 ENSMUST00000050735.10 ENSMUST00000050735.11 ENSMUST00000050735.2 ENSMUST00000050735.3 ENSMUST00000050735.4 ENSMUST00000050735.5 ENSMUST00000050735.6 ENSMUST00000050735.7 ENSMUST00000050735.8 ENSMUST00000050735.9 NM_011981 Q3U170 Q62513 Q8C2Q6 Q9R2B4 ZN260_MOUSE Znf260 uc009gde.1 uc009gde.2 uc009gde.3 Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator. Binds DNA. Interacts with GATA4 (By similarity). Nucleus Predominantly present in heart. Outside the heart, it is detected in embryonic and postnatal vascular smooth muscle cells and in epithelial cells of the lung, gut and kidney at sites of epithelial morphogenesis and in the spinal cord (at protein level). At 9.5 dpc, it is predominantly detected in cardiomyocyte nuclei This expression is maintained throughout embryonic development in the atria and in the ventricular walls and trabeculae. Also present in the outflow tract, the truncus arteriosus, the developing atrioventricular valve and the cushion mesenchyme. Appears to decrease after 14 dpc and by 17.5 dpc; it is then spatially redistributed, with highest levels in subendocardial myocytes and the septum and no expression in epicardial and apical myocytes. It is also strongly expressed in the atrioventricular valve. During postnatal development, it decreases in both atria and ventricles. In the adult heart, expression is found in the aortic valve in scattered cells and in the atria, ventricles, and septum. Interestingly, it is markedly up- regulated in hypertrophied adult ventricles of transgenic mice overexpressing the angiotensin II receptor (at protein level). Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus nucleoplasm cytosol multicellular organism development metal ion binding uc009gde.1 uc009gde.2 uc009gde.3 
ENSMUST00000050744.6 6030498E09Rik ENSMUST00000050744.6 RIKEN cDNA 6030498E09 gene (from RefSeq NM_183126.2) 6030498E09Rik B1AX85 B1AX85_MOUSE ENSMUST00000050744.1 ENSMUST00000050744.2 ENSMUST00000050744.3 ENSMUST00000050744.4 ENSMUST00000050744.5 NM_183126 uc009tah.1 uc009tah.2 uc009tah.3 molecular_function cellular_component biological_process membrane integral component of membrane uc009tah.1 uc009tah.2 uc009tah.3 
ENSMUST00000050758.5 Flg ENSMUST00000050758.5 Flg (from geneSymbol) A0A0A6YY62 A0A0A6YY62_MOUSE ENSMUST00000050758.1 ENSMUST00000050758.2 ENSMUST00000050758.3 ENSMUST00000050758.4 Flg J03458 uc290hfv.1 uc290hfv.2 structural molecule activity uc290hfv.1 uc290hfv.2 
ENSMUST00000050770.6 C5ar1 ENSMUST00000050770.6 complement component 5a receptor 1, transcript variant 1 (from RefSeq NM_007577.4) C5AR1_MOUSE C5ar C5r1 ENSMUST00000050770.1 ENSMUST00000050770.2 ENSMUST00000050770.3 ENSMUST00000050770.4 ENSMUST00000050770.5 NM_007577 P30993 Q3TZ86 uc012faf.1 uc012faf.2 Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Homodimer. May also form higher-order oligomers. Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR. Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist. Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to C5a. Belongs to the G-protein coupled receptor 1 family. microglial cell activation complement component C5a binding complement receptor mediated signaling pathway complement receptor activity complement component C5a receptor activity G-protein coupled receptor activity plasma membrane apoptotic process chemotaxis inflammatory response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell surface positive regulation of vascular endothelial growth factor production positive regulation of macrophage chemotaxis membrane integral component of membrane basolateral plasma membrane cell proliferation in hindbrain neutrophil chemotaxis cytoplasmic vesicle response to peptidoglycan complement component C5a signaling pathway mRNA transcription from RNA polymerase II promoter negative regulation of neuron apoptotic process apical part of cell positive regulation of angiogenesis astrocyte activation positive regulation of epithelial cell proliferation defense response to Gram-positive bacterium cognition positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis beta-amyloid clearance regulation of tau-protein kinase activity uc012faf.1 uc012faf.2 
ENSMUST00000050771.8 Gm11437 ENSMUST00000050771.8 predicted gene 11437 (from RefSeq NM_001037932.2) B0QZI9 B9EK11 CQ078_MOUSE ENSMUST00000050771.1 ENSMUST00000050771.2 ENSMUST00000050771.3 ENSMUST00000050771.4 ENSMUST00000050771.5 ENSMUST00000050771.6 ENSMUST00000050771.7 NM_001037932 Q5QR91 Q5SWU4 uc007kqi.1 uc007kqi.2 uc007kqi.3 uc007kqi.4 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007kqi.1 uc007kqi.2 uc007kqi.3 uc007kqi.4 
ENSMUST00000050776.9 Barhl1 ENSMUST00000050776.9 BarH like homeobox 1, transcript variant 1 (from RefSeq NM_019446.5) BARH1_MOUSE Bhx1 ENSMUST00000050776.1 ENSMUST00000050776.2 ENSMUST00000050776.3 ENSMUST00000050776.4 ENSMUST00000050776.5 ENSMUST00000050776.6 ENSMUST00000050776.7 ENSMUST00000050776.8 Mbh2 NM_019446 P63157 Q9JK26 uc008izh.1 uc008izh.2 uc008izh.3 uc008izh.4 Nucleus Exclusively expressed in restricted domains of the developing central nervous system, in particular the diencephalon and rhombencephalon, where it is expressed in migrating cells giving rise to the cerebellar external granular layer and to specific populations of dorsal sensory interneurons of the spinal cord. Belongs to the BAR homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding neuron migration DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nervous system development sensory perception of sound tissue development midbrain development negative regulation of neuron apoptotic process sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter animal organ development uc008izh.1 uc008izh.2 uc008izh.3 uc008izh.4 
ENSMUST00000050780.8 Nat8f3 ENSMUST00000050780.8 N-acetyltransferase 8 (GCN5-related) family member 3 (from RefSeq NM_001037842.3) A0A0R4J157 A0A0R4J157_MOUSE ENSMUST00000050780.1 ENSMUST00000050780.2 ENSMUST00000050780.3 ENSMUST00000050780.4 ENSMUST00000050780.5 ENSMUST00000050780.6 ENSMUST00000050780.7 NM_001037842 Nat8f3 uc009cqd.1 uc009cqd.2 uc009cqd.3 uc009cqd.4 Belongs to the camello family. N-acetyltransferase activity membrane integral component of membrane uc009cqd.1 uc009cqd.2 uc009cqd.3 uc009cqd.4 
ENSMUST00000050785.14 Lcn2 ENSMUST00000050785.14 lipocalin 2 (from RefSeq NM_008491.1) ENSMUST00000050785.1 ENSMUST00000050785.10 ENSMUST00000050785.11 ENSMUST00000050785.12 ENSMUST00000050785.13 ENSMUST00000050785.2 ENSMUST00000050785.3 ENSMUST00000050785.4 ENSMUST00000050785.5 ENSMUST00000050785.6 ENSMUST00000050785.7 ENSMUST00000050785.8 ENSMUST00000050785.9 NGAL_MOUSE NM_008491 P11672 Q3UE34 uc008jfl.1 uc008jfl.2 uc008jfl.3 Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:15531878, PubMed:16446425). Can also bind siderophores from M.tuberculosis (By similarity). Monomer. Homodimer; disulfide-linked. Heterodimer; disulfide- linked with MMP9. Secreted toplasmic granule lumen Cytoplasmic vesicle lumen Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (PubMed:16377569). Releases the bound iron in the acidic lumen of cytoplasmic vesicles (By similarity). Expressed in the cortical tubules of the kidney (at protein level) (PubMed:30418175). Also expressed in the medullary tubules of the kidney (PubMed:30418175). Detected in lung, spleen, uterus, vagina and epididymis (PubMed:8687399). Upon Toll-like receptor (TLRs) stimuli (PubMed:15531878). By SV-40 (PubMed:15531878). By insulin (PubMed:30418175). N-glycosylated. Mice are normal with no visible phenotype. They however show an increased susceptibility to bacterial infections. Neutrophils show significantly less bacteriostatic activity. Belongs to the calycin superfamily. Lipocalin family. protease binding immune system process iron ion binding protein binding extracellular region extracellular space cytosol ion transport apoptotic process response to oxidative stress response to virus response to bacterium response to herbicide response to mycotoxin positive regulation of gene expression siderophore transport positive regulation of cell projection organization cytoplasmic vesicle response to nutrient levels cellular response to nutrient levels small molecule binding response to drug defense response to bacterium protein homodimerization activity innate immune response iron ion homeostasis cytoplasmic vesicle lumen protein homotrimerization cellular response to hydrogen peroxide cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor extrinsic apoptotic signaling pathway in absence of ligand sequestering of iron ion enterobactin binding uc008jfl.1 uc008jfl.2 uc008jfl.3 
ENSMUST00000050813.4 Mterf2 ENSMUST00000050813.4 mitochondrial transcription termination factor 2, transcript variant 4 (from RefSeq NM_028832.3) ENSMUST00000050813.1 ENSMUST00000050813.2 ENSMUST00000050813.3 MTEF2_MOUSE Mterfd3 NM_028832 Q8BKY8 uc007gld.1 uc007gld.2 uc007gld.3 Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species. Monomer. Mitochondrion matrix, mitochondrion nucleoid Belongs to the mTERF family. DNA binding double-stranded DNA binding mitochondrion regulation of transcription, DNA-templated termination of mitochondrial transcription mitochondrial nucleoid uc007gld.1 uc007gld.2 uc007gld.3 
ENSMUST00000050826.14 Tet1 ENSMUST00000050826.14 Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. (from UniProt A0A9L6H7S7) A0A9L6H7S7 A0A9L6H7S7_MOUSE ENSMUST00000050826.1 ENSMUST00000050826.10 ENSMUST00000050826.11 ENSMUST00000050826.12 ENSMUST00000050826.13 ENSMUST00000050826.2 ENSMUST00000050826.3 ENSMUST00000050826.4 ENSMUST00000050826.5 ENSMUST00000050826.6 ENSMUST00000050826.7 ENSMUST00000050826.8 ENSMUST00000050826.9 GU079948 Tet1 uc007fje.1 uc007fje.2 uc007fje.3 Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. Reaction=2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate; Xref=Rhea:RHEA:53832, Rhea:RHEA-COMP:13656, Rhea:RHEA-COMP:13657, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:137731, ChEBI:CHEBI:137732; EC=1.14.11.80; Evidence= Reaction=2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 = a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate; Xref=Rhea:RHEA:53828, Rhea:RHEA-COMP:13315, Rhea:RHEA-COMP:13656, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:136731, ChEBI:CHEBI:137731; EC=1.14.11.80; Evidence= Reaction=2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate; Xref=Rhea:RHEA:52636, Rhea:RHEA-COMP:11370, Rhea:RHEA-COMP:13315, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:85454, ChEBI:CHEBI:136731; EC=1.14.11.80; Evidence= Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=The zinc ions have a structural role. ; Chromosome Belongs to the TET family. uc007fje.1 uc007fje.2 uc007fje.3 
ENSMUST00000050864.7 Prm3 ENSMUST00000050864.7 protamine 3 (from RefSeq NM_013638.2) A3KMD8 ENSMUST00000050864.1 ENSMUST00000050864.2 ENSMUST00000050864.3 ENSMUST00000050864.4 ENSMUST00000050864.5 ENSMUST00000050864.6 NM_013638 PRM3_MOUSE Q5BKQ3 Q62100 uc007yef.1 uc007yef.2 uc007yef.3 Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. Nucleus. Chromosome. Testis. Belongs to the protamine P3 family. nucleosome DNA binding nucleus chromosome cytoplasm multicellular organism development spermatogenesis cell differentiation chromosome condensation flagellated sperm motility uc007yef.1 uc007yef.2 uc007yef.3 
ENSMUST00000050867.8 Cactin ENSMUST00000050867.8 cactin, spliceosome C complex subunit (from RefSeq NM_027381.2) CATIN_MOUSE ENSMUST00000050867.1 ENSMUST00000050867.2 ENSMUST00000050867.3 ENSMUST00000050867.4 ENSMUST00000050867.5 ENSMUST00000050867.6 ENSMUST00000050867.7 NM_027381 Q9CS00 uc007ghf.1 uc007ghf.2 uc007ghf.3 uc007ghf.4 Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity). Required for the splicing of CDCA5/Sororin, a regulator of sister chromatid cohesion (By similarity). Involved in the regulation of innate immune response (By similarity). Acts as a negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (By similarity). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (By similarity). Interacts (via N-terminal domain) with NFKBIL1; the interaction occurs in a pro-inflammatory-independent manner (By similarity). Does not interact with RELA NF-kappa-B subunit (By similarity). Identified in the spliceosome C complex (By similarity). Interacts with SF3B1 (By similarity). Interacts with SDE2 (By similarity). Interacts with SRRM2 (By similarity). Interacts with DHX8 (By similarity). Nucleus Cytoplasm, cytosol Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus (By similarity). Expressed in cortex, hippocampus, cerebellum, heart, lung, kidney, liver, spleen and thymus. Belongs to the CACTIN family. negative regulation of protein phosphorylation immune system process nucleus nucleoplasm spliceosomal complex cytosol mRNA processing multicellular organism development RNA splicing nuclear speck negative regulation of lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity negative regulation of interferon-beta production negative regulation of interleukin-8 production negative regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway innate immune response negative regulation of type I interferon-mediated signaling pathway catalytic step 2 spliceosome cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor uc007ghf.1 uc007ghf.2 uc007ghf.3 uc007ghf.4 
ENSMUST00000050872.15 Nfib ENSMUST00000050872.15 nuclear factor I/B, transcript variant 1 (from RefSeq NM_001113209.2) ENSMUST00000050872.1 ENSMUST00000050872.10 ENSMUST00000050872.11 ENSMUST00000050872.12 ENSMUST00000050872.13 ENSMUST00000050872.14 ENSMUST00000050872.2 ENSMUST00000050872.3 ENSMUST00000050872.4 ENSMUST00000050872.5 ENSMUST00000050872.6 ENSMUST00000050872.7 ENSMUST00000050872.8 ENSMUST00000050872.9 NFIB_MOUSE NM_001113209 P70252 P70253 P70254 P97863 Q9R1G4 uc008tkc.1 uc008tkc.2 uc008tkc.3 uc008tkc.4 uc008tkc.5 Transcriptional activator of GFAP, essential for proper brain development (PubMed:15632069, PubMed:30388402). Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication (PubMed:30388402). Binds DNA as a homodimer. Nucleus. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P97863-1; Sequence=Displayed; Name=2; IsoId=P97863-2; Sequence=VSP_003547; Name=3; IsoId=P97863-3; Sequence=VSP_003548, VSP_003549; Highest expression in lung, skeletal muscle and heart. Lower levels in liver, kidney and brain. Very low levels in testis and spleen. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. NFIB knockout results in failure of lung maturation, and severe defects in development of the corpus callosum, specific midline glial populations, the hippocampus and the pons. GFAP expression is reduced in brains of NFIB-null mice (PubMed:15632069). Conditional NFIB knockdown in the telencephalon results in significant enlargement of the cerebral cortex with preservation of overall brain structure and inter-hemispheric connectivity (PubMed:30388402). Belongs to the CTF/NF-I family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding fibrillar center chondrocyte differentiation DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity nucleus DNA replication regulation of transcription, DNA-templated brain development negative regulation of cell proliferation response to bacterium glial cell differentiation principal sensory nucleus of trigeminal nerve development anterior commissure morphogenesis lung development forebrain development hindbrain development negative regulation of DNA binding cerebellar mossy fiber positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter Clara cell differentiation Type I pneumocyte differentiation Type II pneumocyte differentiation salivary gland cavitation cell differentiation involved in salivary gland development lung ciliated cell differentiation commissural neuron axon guidance negative regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of mesenchymal cell proliferation involved in lung development negative regulation of epithelial cell proliferation involved in lung morphogenesis uc008tkc.1 uc008tkc.2 uc008tkc.3 uc008tkc.4 uc008tkc.5 
ENSMUST00000050880.8 Slc26a11 ENSMUST00000050880.8 solute carrier family 26, member 11 (from RefSeq NM_178743.3) B2RQF3 ENSMUST00000050880.1 ENSMUST00000050880.2 ENSMUST00000050880.3 ENSMUST00000050880.4 ENSMUST00000050880.5 ENSMUST00000050880.6 ENSMUST00000050880.7 NM_178743 Q80ZD3 Q8BTP1 Q8BWL3 Q8CHW8 S2611_MOUSE Slc26a11 uc007mqm.1 uc007mqm.2 uc007mqm.3 Sodium-independent anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport (By similarity). Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC) (By similarity). In the kidney, mediates chloride-bicarbonate exchange, facilitating V- ATPase-mediated acid secretion (PubMed:21716257). May function as a chloride channel, playing an important role in moderating chloride homeostasis and neuronal activity in the cerebellum (PubMed:23733100, PubMed:27390771). Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) + hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996; Evidence=; Reaction=H(+)(in) + sulfate(in) = H(+)(out) + sulfate(out); Xref=Rhea:RHEA:28574, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189; Evidence=; Reaction=chloride(out) + oxalate(in) = chloride(in) + oxalate(out); Xref=Rhea:RHEA:72263, ChEBI:CHEBI:17996, ChEBI:CHEBI:30623; Evidence=; Cell membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 IsoId=Q80ZD3-1; Sequence=Displayed; Name=2 ; IsoId=Q80ZD3-2; Sequence=VSP_052687, VSP_052688; Abundantly expressed in the cerebellum, with a predominant expression in Purkinje cells (at protein level). [Isoform 1]: Predominantly expressed in the kidney and brain (PubMed:21716257). In the kidney localizes in collecting duct intercalated cells (at protein level) (PubMed:21716257). [Isoform 2]: Predominantly expressed in the brain with lower levels in the kidney. Conditional knockout from Purkinje cells (PCs) induces a negative shift in the reversal potential of chloride as reflected in the GABAA-receptor evoked currents, indicating a decrease in intracellular chloride concentration. Both in vitro and in vivo, PCs show a significantly increased action potential firing frequency of simple spikes. At the behavioral level, mice show deficits in locomotor activity. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Sequence=AAH38604.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleoplasm lysosome lysosomal membrane endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane ion transport secondary active sulfate transmembrane transporter activity sulfate transport anion transmembrane transporter activity sulfate transmembrane transporter activity anion:anion antiporter activity membrane integral component of membrane intracellular membrane-bounded organelle transmembrane transport anion transmembrane transport sulfate transmembrane transport uc007mqm.1 uc007mqm.2 uc007mqm.3 
ENSMUST00000050882.4 Krtap13-22 ENSMUST00000050882.4 RIKEN cDNA 2310061N02 gene (from RefSeq NM_027155.1) 2310061N02Rik ENSMUST00000050882.1 ENSMUST00000050882.2 ENSMUST00000050882.3 NM_027155 Q9D6S9 Q9D6S9_MOUSE uc012ahu.1 uc012ahu.2 uc012ahu.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the PMG family. protein binding cellular_component biological_process uc012ahu.1 uc012ahu.2 uc012ahu.3 
ENSMUST00000050884.16 Hmgn1 ENSMUST00000050884.16 high mobility group nucleosomal binding domain 1 (from RefSeq NM_008251.3) ENSMUST00000050884.1 ENSMUST00000050884.10 ENSMUST00000050884.11 ENSMUST00000050884.12 ENSMUST00000050884.13 ENSMUST00000050884.14 ENSMUST00000050884.15 ENSMUST00000050884.2 ENSMUST00000050884.3 ENSMUST00000050884.4 ENSMUST00000050884.5 ENSMUST00000050884.6 ENSMUST00000050884.7 ENSMUST00000050884.8 ENSMUST00000050884.9 HMGN1_MOUSE Hmg-14 Hmg14 NM_008251 P18608 Q5HZY9 uc008aco.1 uc008aco.2 uc008aco.3 Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. Interacts with transcriptional regulator SEHBP. Nucleus. Cytoplasm Note=Cytoplasmic enrichment upon phosphorylation. Phosphorylation favors cytoplasmic localization (By similarity). Phosphorylation on Ser-20 and Ser-24 weakens binding to nucleosomes and increases the rate of H3 phosphorylation. Belongs to the HMGN family. pyrimidine dimer repair by nucleotide-excision repair chromatin DNA binding chromatin binding protein binding nucleus cytoplasm transcription-coupled nucleotide-excision repair chromatin organization regulation of transcription from RNA polymerase II promoter response to UV-B response to UV-C nucleosomal DNA binding regulation of development, heterochronic post-embryonic camera-type eye morphogenesis regulation of epithelial cell proliferation positive regulation of NAD+ ADP-ribosyltransferase activity uc008aco.1 uc008aco.2 uc008aco.3 
ENSMUST00000050890.8 Neu4 ENSMUST00000050890.8 sialidase 4, transcript variant 2 (from RefSeq NM_173772.3) ENSMUST00000050890.1 ENSMUST00000050890.2 ENSMUST00000050890.3 ENSMUST00000050890.4 ENSMUST00000050890.5 ENSMUST00000050890.6 ENSMUST00000050890.7 NEUR4_MOUSE NM_173772 Q6NS66 Q8BZL1 uc007ceu.1 uc007ceu.2 uc007ceu.3 Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha- (2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:19506080, PubMed:22393058). Hydrolyzes poly-alpha-(2->8)- sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (PubMed:19506080, PubMed:22393058). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (By similarity). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:19506080, PubMed:22393058). Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha- (2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.; EC=3.2.1.18; Evidence=; Reaction=a ganglioside GM3 + H2O = a beta-D-galactosyl-(1->4)-beta-D- glucosyl-(1<->1)-ceramide + N-acetylneuraminate; Xref=Rhea:RHEA:48136, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:79208, ChEBI:CHEBI:79210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48137; Evidence=; Reaction=a ganglioside GM3 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)- beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:47900, ChEBI:CHEBI:15377, ChEBI:CHEBI:17950, ChEBI:CHEBI:35418, ChEBI:CHEBI:60065; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47901; Evidence=; Reaction=a ganglioside GM2 + H2O = a ganglioside GA2 + N- acetylneuraminate; Xref=Rhea:RHEA:48172, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:79218, ChEBI:CHEBI:90085; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48173; Evidence=; Reaction=a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:48068, ChEBI:CHEBI:15377, ChEBI:CHEBI:27731, ChEBI:CHEBI:35418, ChEBI:CHEBI:71502; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48069; Evidence=; Reaction=a ganglioside GD1a + H2O = a ganglioside GM1 + N- acetylneuraminate; Xref=Rhea:RHEA:47832, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:82637, ChEBI:CHEBI:82639; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47833; Evidence=; Reaction=a ganglioside GD1a (d18:1(4E)) + H2O = a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:47856, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:77709, ChEBI:CHEBI:78445; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47857; Evidence=; Reaction=a ganglioside GD3 + H2O = a ganglioside GM3 + N- acetylneuraminate; Xref=Rhea:RHEA:48120, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:79210, ChEBI:CHEBI:79214; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48121; Evidence=; Reaction=a ganglioside GD3 (d18:1(4E)) + H2O = a ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:48124, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:60065, ChEBI:CHEBI:78436; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48125; Evidence=; pH dependence: Optimum pH is 4.4-6.5. ; Cell membrane ; Peripheral membrane protein. Endoplasmic reticulum membrane ; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein. Mitochondrion inner membrane ; Peripheral membrane protein. Mitochondrion outer membrane ; Peripheral membrane protein. Cell projection, neuron projection Lysosome lumen Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZL1-2; Sequence=Displayed; Name=2; IsoId=Q8BZL1-1; Sequence=VSP_037492; Highly expressed in brain, particularly in hippocampus, and at lower levels in liver and spleen. Expressed in hippocampal neurons (at protein level). Expressed at low levels in embryonic brain, then rapidly up-regulated after birth reaching a maximum at postnatal day 14, followed by a decrease. Down-regulated upon neuron differentiation. Belongs to the glycosyl hydrolase 33 family. exo-alpha-sialidase activity cytoplasm mitochondrion lysosome carbohydrate metabolic process glycoprotein catabolic process lipid metabolic process ganglioside catabolic process metabolic process oligosaccharide catabolic process membrane lipid catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds organelle inner membrane intracellular membrane-bounded organelle exo-alpha-(2->3)-sialidase activity exo-alpha-(2->6)-sialidase activity exo-alpha-(2->8)-sialidase activity uc007ceu.1 uc007ceu.2 uc007ceu.3 
ENSMUST00000050897.7 Spice1 ENSMUST00000050897.7 spindle and centriole associated protein 1, transcript variant 5 (from RefSeq NR_184401.1) Ccdc52 D16Ertd480e ENSMUST00000050897.1 ENSMUST00000050897.2 ENSMUST00000050897.3 ENSMUST00000050897.4 ENSMUST00000050897.5 ENSMUST00000050897.6 NR_184401 Q8C804 Q8K3I7 SPICE_MOUSE uc007zhg.1 uc007zhg.2 uc007zhg.3 uc007zhg.4 Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. Interacts with CEP120. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle molecular_function cytoplasm centrosome centriole spindle cytoskeleton cell cycle regulation of centriole replication cell division metaphase plate congression mitotic spindle assembly uc007zhg.1 uc007zhg.2 uc007zhg.3 uc007zhg.4 
ENSMUST00000050901.5 Apof ENSMUST00000050901.5 apolipoprotein F (from RefSeq NM_133997.3) APOF_MOUSE ENSMUST00000050901.1 ENSMUST00000050901.2 ENSMUST00000050901.3 ENSMUST00000050901.4 Lvif NM_133997 Q91V80 uc007hlz.1 uc007hlz.2 uc007hlz.3 uc007hlz.4 Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII. Secreted Liver. Belongs to the apolipoprotein F family. Sequence=AAH10815.1; Type=Erroneous initiation; Evidence=; Sequence=AAH22795.1; Type=Erroneous initiation; Evidence=; Sequence=AAH24769.1; Type=Erroneous initiation; Evidence=; Sequence=AAH25827.1; Type=Erroneous initiation; Evidence=; Sequence=AAL06339.1; Type=Erroneous initiation; Evidence=; Sequence=AAL06340.1; Type=Erroneous initiation; Evidence=; Sequence=AAL06341.1; Type=Erroneous initiation; Evidence=; molecular_function extracellular region extracellular space lipid metabolic process triglyceride metabolic process lipid transport steroid metabolic process cholesterol metabolic process cholesterol efflux low-density lipoprotein particle high-density lipoprotein particle uc007hlz.1 uc007hlz.2 uc007hlz.3 uc007hlz.4 
ENSMUST00000050916.7 Snx33 ENSMUST00000050916.7 sorting nexin 33 (from RefSeq NM_175483.5) ENSMUST00000050916.1 ENSMUST00000050916.2 ENSMUST00000050916.3 ENSMUST00000050916.4 ENSMUST00000050916.5 ENSMUST00000050916.6 NM_175483 Q4VAA7 Q8BPM5 Q8C832 SNX33_MOUSE Sh3px3 uc009ptp.1 uc009ptp.2 uc009ptp.3 Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes (By similarity). Homodimer (via BAR domain). Interacts with ADAM15. Interacts with FASLG. Interacts (via SH3 domain) with DNM1 and DNM2. Interacts with WASL (By similarity). Interacts with FCHSD1 (via the F-BAR domain) (PubMed:26567222). Cytoplasm, cytosol Membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Primarily detected in the cytosol. A minor proportion is membrane-bound (By similarity). Detected in brain (at protein level). The PX and BAR domains mediate association with membranes and are required for membrane tubulation. Phosphorylated. Belongs to the sorting nexin family. mitotic cell cycle mitotic cytokinesis cytoplasm cytosol intracellular protein transport endocytosis endosome organization cell cycle protein transport membrane endosomal transport protein import extrinsic component of membrane cytoplasmic vesicle membrane cytoplasmic vesicle phosphatidylinositol binding cleavage furrow formation identical protein binding macropinocytosis negative regulation of endocytosis positive regulation of membrane protein ectodomain proteolysis cell division plasma membrane tubulation negative regulation of protein localization to cell surface positive regulation of protein localization to cell surface uc009ptp.1 uc009ptp.2 uc009ptp.3 
ENSMUST00000050918.4 Camk2n1 ENSMUST00000050918.4 calcium/calmodulin-dependent protein kinase II inhibitor 1 (from RefSeq NM_025451.2) CK2N1_MOUSE ENSMUST00000050918.1 ENSMUST00000050918.2 ENSMUST00000050918.3 NM_025451 Q6QWF9 uc008vkz.1 uc008vkz.2 uc008vkz.3 uc008vkz.4 Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval- induced memory in response to contextual fear (PubMed:28642476). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post- myocardial infarction (PubMed:33746041). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (PubMed:31327268). Interacts with CAMK2B; the presence of Ca(2+)/calmodulin increases the interaction but is not essential (By similarity). Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca(2+) (By similarity). Synapse ll projection, dendrite Postsynaptic density Expressed in the brain (at protein level) (PubMed:17350603). Expressed in cardiomyocytes but not cardiac fibroblasts (at protein level) (PubMed:33746041). Up-regulated during retrieval and consolidation of fear memory (PubMed:16819996, PubMed:28642476). Down-regulated in brain during Japanese encephalitis virus (JEV) and rabies virus infection (PubMed:17010311). Knockout mice show normal growth rates (PubMed:33746041). Increased expression of inflammatory markers and enhanced recruitment of macrophages to the cardiac infarct border 3 days post-myocardial infarction (MI) (PubMed:33746041). Increased infarct size, interstitial fibrosis, and area of cardiac hypertrophy, leading to decreased left ventricular ejection fractions, fractional shortening and increased spontaneous ventricular arrhythmia at 28 days post MI (PubMed:33746041). Overall survival of mice following MI was significantly decreased (PubMed:33746041). In hippocampal knockdown mice, long-term retrieval-induced memory in response to contextual fear is impaired (PubMed:28642476). Increase in Camk2a T-296 autophosphorylation and Gria1/GluA1 abundance following conditioning and long-term memory retrieval (PubMed:28642476). Belongs to the CAMK2N family. protein kinase inhibitor activity plasma membrane negative regulation of protein kinase activity negative regulation of cell proliferation calcium-dependent protein kinase inhibitor activity positive regulation of gene expression postsynaptic density membrane protein kinase binding cell junction dendrite neuron projection neuronal cell body synapse postsynaptic membrane negative regulation of cell cycle negative regulation of proteolysis negative regulation of ERK1 and ERK2 cascade negative regulation of cyclin-dependent protein kinase activity uc008vkz.1 uc008vkz.2 uc008vkz.3 uc008vkz.4 
ENSMUST00000050921.3 A230052G05Rik ENSMUST00000050921.3 A230052G05Rik (from geneSymbol) AK079546 ENSMUST00000050921.1 ENSMUST00000050921.2 uc292atc.1 uc292atc.2 uc292atc.1 uc292atc.2 
ENSMUST00000050933.9 Oog3 ENSMUST00000050933.9 oogenesin 3 (from RefSeq NM_201258.2) ENSMUST00000050933.1 ENSMUST00000050933.2 ENSMUST00000050933.3 ENSMUST00000050933.4 ENSMUST00000050933.5 ENSMUST00000050933.6 ENSMUST00000050933.7 ENSMUST00000050933.8 NM_201258 OOG3_MOUSE Oog3 Q3UWY1 Q7TPT9 uc008vqx.1 uc008vqx.2 uc008vqx.3 uc008vqx.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UWY1-1; Sequence=Displayed; Name=2; IsoId=Q3UWY1-2; Sequence=VSP_059016; Expressed in ovary, specifically in oocytes. Detected in follicles with two layers of granulosa cells, and are present in early as well as large antral follicles. Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vqx.1 uc008vqx.2 uc008vqx.3 uc008vqx.4 
ENSMUST00000050937.7 Timd6 ENSMUST00000050937.7 T cell immunoglobulin and mucin domain containing 6 (from RefSeq NM_001025435.3) A0A0B4J1F6 A0A0B4J1F6_MOUSE BC053393 ENSMUST00000050937.1 ENSMUST00000050937.2 ENSMUST00000050937.3 ENSMUST00000050937.4 ENSMUST00000050937.5 ENSMUST00000050937.6 NM_001025435 Timd6 uc007ioo.1 uc007ioo.2 uc007ioo.3 uc007ioo.4 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the immunoglobulin superfamily. TIM family. molecular_function cellular_component biological_process membrane integral component of membrane uc007ioo.1 uc007ioo.2 uc007ioo.3 uc007ioo.4 
ENSMUST00000050940.4 Foxe3 ENSMUST00000050940.4 forkhead box E3 (from RefSeq NM_015758.3) ENSMUST00000050940.1 ENSMUST00000050940.2 ENSMUST00000050940.3 FOXE3_MOUSE NM_015758 Q9QY14 uc008uef.1 uc008uef.2 Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:10652278, PubMed:10890982). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (PubMed:16199865). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (PubMed:10652278). Is required for morphogenesis and differentiation of the anterior segment of the eye (PubMed:17064680). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (By similarity). Nucleus Expressed in the embryonic lens. Expressed in the developing lens from the start of lens placode induction and becomes restricted to the anterior proliferating cells when lens fiber differentiation begins. Head ectoderm expression is induced by RAX and lens expression is induced by PAX6. Note=Defects in Foxe3 are the cause of the dysgenetic lens (dyl) phenotype. In mouse mutant dyl the lens vesicle fails to separate from the ectoderm, causing a fusion between the lens and the cornea. Lack of a proliferating anterior lens epithelium leads to absence of secondary lens fibers and a dysplastic, cataractous lens. Knockout mice are viable and fertile but show eye abnormalities; in some cases the eyes never open. Eyes are much smaller, the anterior chamber is not formed, and the pupil is markedly smaller. There are no abnormalities in brain development (PubMed:16199865). Mice show reduced smooth muscle cell (SMC) density and impaired SMC differentiation that is limited to the ascending aorta (PubMed:26854927). RNA polymerase II transcription factor activity, sequence-specific DNA binding eye development lens development in camera-type eye trabecular meshwork development DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter anatomical structure morphogenesis cell differentiation mRNA transcription from RNA polymerase II promoter camera-type eye development negative regulation of apoptotic process sequence-specific DNA binding cell development positive regulation of epithelial cell proliferation iris morphogenesis ciliary body morphogenesis cornea development in camera-type eye negative regulation of cell cycle arrest negative regulation of lens fiber cell differentiation positive regulation of lens epithelial cell proliferation uc008uef.1 uc008uef.2 
ENSMUST00000050952.4 Stbd1 ENSMUST00000050952.4 starch binding domain 1 (from RefSeq NM_175096.3) D5Ertd593e ENSMUST00000050952.1 ENSMUST00000050952.2 ENSMUST00000050952.3 NM_175096 Q147T8 Q8C7E7 STBD1_MOUSE Stbd1 uc008ydp.1 uc008ydp.2 Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. Interacts with the ATG8 family proteins GABARAP and GABARAPL1 (By similarity). Interacts with several glycogen-associated proteins, such as GYS2 (liver glycogen synthase), GDE (glycogen debranching enzyme), GBE1 (glycogen branching enzyme 1) and EPM2A (Laforin) (By similarity). Preautophagosomal structure membrane ; Single- pass type III membrane protein Endoplasmic reticulum membrane ; Single- pass type III membrane protein Cell membrane, sarcolemma, T-tubule Note=Also detected near the junctional sarcoplasmic reticulum (By similarity). Concentrates at perinuclear structures (PubMed:20810658). Expressed at high level in glycogen-accumulating organs such as muscle and liver. Trace signals are also found in brain, kidney, and pancreas. The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family protein GABARAPL1. The C-terminal CBM20 domain is required for the interaction with glycogen. Ubiquitinated, which leads to proteasomal degradation. endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane integral component of plasma membrane carbohydrate metabolic process glycogen metabolic process glycogen catabolic process autophagy membrane integral component of membrane enzyme binding carbohydrate binding polysaccharide binding T-tubule pre-autophagosomal structure membrane intracellular transport perinuclear region of cytoplasm glycophagy glycogen binding starch binding uc008ydp.1 uc008ydp.2 
ENSMUST00000050958.9 Tmie ENSMUST00000050958.9 transmembrane inner ear (from RefSeq NM_146260.3) ENSMUST00000050958.1 ENSMUST00000050958.2 ENSMUST00000050958.3 ENSMUST00000050958.4 ENSMUST00000050958.5 ENSMUST00000050958.6 ENSMUST00000050958.7 ENSMUST00000050958.8 NM_146260 Q8K467 TMIE_MOUSE uc009rvb.1 uc009rvb.2 uc009rvb.3 Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain. Interacts with TOMT. Membrane ; Single-pass type I membrane protein Expressed in brain, kidney, liver, lung and cochlea. Required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. Note=Defects in Tmie are the cause of the spinner mutant strain phenotype (sr). This disorder results in hearing loss and vestibular dysfunction due to neuroepithelial defects in the inner ear. It is recognized by behavioral dysfunction, including bidirectional circling and head shaking. Auditory function in spinner mice is found to be reduced, based upon the lack of a startle reflex to sound at any age. Breeding experiments indicated that these defects are inherited in an autosomal recessive fashion. The postnatal defects present in the cochleae of sr/sr mice suggest a requirement for Tmie during maturation of sensory cells, including the normal development or maintenance of stereocilia bundles. protein binding sensory perception of sound membrane integral component of membrane inner ear morphogenesis uc009rvb.1 uc009rvb.2 uc009rvb.3 
ENSMUST00000050962.5 Cldn14 ENSMUST00000050962.5 claudin 14, transcript variant 1 (from RefSeq NM_019500.4) CLD14_MOUSE ENSMUST00000050962.1 ENSMUST00000050962.2 ENSMUST00000050962.3 ENSMUST00000050962.4 NM_019500 Q9D284 Q9Z0S3 uc008aad.1 uc008aad.2 uc008aad.3 uc008aad.4 This gene encodes a member of the claudin family of tight junction proteins. The encoded protein is an integral membrane protein that may function in maintaining apical membrane polarization in tight junctions located between outer hair cells and supporting cells. Loss of function of this gene is associated with hearing problems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Q9Z0S3; Q9Y5I7: CLDN16; Xeno; NbExp=3; IntAct=EBI-7774956, EBI-7774981; Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Expressed in all sensory epithelia of the inner ear vestibular organs, as well as in liver and kidney. At postnatal day 4, expression is apically located in the inner and outer hair cell region of the entire organ of Corti. By postnatal day 8, expression is highest in the supporting cells of the organ of Corti. Belongs to the claudin family. structural molecule activity protein binding plasma membrane bicellular tight junction membrane integral component of membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding uc008aad.1 uc008aad.2 uc008aad.3 uc008aad.4 
ENSMUST00000050963.4 Il17c ENSMUST00000050963.4 interleukin 17C (from RefSeq NM_145834.4) A0A0R4J0P4 A0A0R4J0P4_MOUSE ENSMUST00000050963.1 ENSMUST00000050963.2 ENSMUST00000050963.3 Il17c NM_145834 uc012gmc.1 uc012gmc.2 uc012gmc.3 uc012gmc.4 Secreted Belongs to the IL-17 family. cytokine activity extracellular region inflammatory response signal transduction uc012gmc.1 uc012gmc.2 uc012gmc.3 uc012gmc.4 
ENSMUST00000050970.4 Polr1d ENSMUST00000050970.4 polymerase (RNA) I polypeptide D, transcript variant 1 (from RefSeq NM_009087.2) ENSMUST00000050970.1 ENSMUST00000050970.2 ENSMUST00000050970.3 NM_009087 Polr1d Q545W2 Q545W2_MOUSE Rpo1-3 uc009anu.1 uc009anu.2 uc009anu.3 uc009anu.4 This gene encodes an RNA polymerase subunit that is a component of both the RNA polymerase I and RNA polymerase III complexes. RNA polymerase I is associated with transcription of pre-ribosomal RNAs, while RNA polymerase III is associated with transcription of small RNAs. Pseudogenes of this gene have been defined on chromosomes 4 and 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively. Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family. DNA binding DNA-directed 5'-3' RNA polymerase activity transcription, DNA-templated protein dimerization activity uc009anu.1 uc009anu.2 uc009anu.3 uc009anu.4 
ENSMUST00000050975.6 Lingo4 ENSMUST00000050975.6 leucine rich repeat and Ig domain containing 4, transcript variant 1 (from RefSeq NM_177250.3) A0A4X2 ENSMUST00000050975.1 ENSMUST00000050975.2 ENSMUST00000050975.3 ENSMUST00000050975.4 ENSMUST00000050975.5 LIGO4_MOUSE Lrrn6d NM_177250 Q149C3 uc008qgb.1 uc008qgb.2 uc008qgb.3 Membrane ; Single-pass type I membrane protein Sequence=AAI17867.1; Type=Erroneous initiation; Evidence=; Sequence=AAI17868.1; Type=Erroneous initiation; Evidence=; Sequence=BAC31214.1; Type=Frameshift; Evidence=; molecular_function extracellular space membrane integral component of membrane extracellular matrix positive regulation of synapse assembly uc008qgb.1 uc008qgb.2 uc008qgb.3 
ENSMUST00000050997.2 Rfesd ENSMUST00000050997.2 Rieske (Fe-S) domain containing, transcript variant 1 (from RefSeq NM_178916.5) ENSMUST00000050997.1 NM_178916 Q3TQH9 Q8K2P6 RFESD_MOUSE uc007rgd.1 uc007rgd.2 Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 1 [2Fe-2S] cluster per subunit. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2P6-1; Sequence=Displayed; Name=2; IsoId=Q8K2P6-2; Sequence=VSP_030156, VSP_030157; cellular_component biological_process nitrite reductase [NAD(P)H] activity oxidoreductase activity metal ion binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding oxidation-reduction process uc007rgd.1 uc007rgd.2 
ENSMUST00000051011.14 Tmem198b ENSMUST00000051011.14 transmembrane protein 198b, transcript variant 1 (from RefSeq NM_178066.3) 1110012D08Rik ENSMUST00000051011.1 ENSMUST00000051011.10 ENSMUST00000051011.11 ENSMUST00000051011.12 ENSMUST00000051011.13 ENSMUST00000051011.2 ENSMUST00000051011.3 ENSMUST00000051011.4 ENSMUST00000051011.5 ENSMUST00000051011.6 ENSMUST00000051011.7 ENSMUST00000051011.8 ENSMUST00000051011.9 NM_178066 Q8CFU0 Q8CFU0_MOUSE Tmem198b uc007hoi.1 uc007hoi.2 Membrane ; Multi- pass membrane protein Belongs to the TMEM198 family. molecular_function plasma membrane vesicle membrane membrane integral component of membrane cytoplasmic vesicle positive regulation of canonical Wnt signaling pathway uc007hoi.1 uc007hoi.2 
ENSMUST00000051014.2 Exph5 ENSMUST00000051014.2 exophilin 5 (from RefSeq NM_176846.3) ENSMUST00000051014.1 EXPH5_MOUSE Exph5 Kiaa0624 NM_176846 Q0VAV2 Q3UNV5 Q6A034 Q812E3 Slac2b uc009pma.1 uc009pma.2 uc009pma.3 uc009pma.4 May act as Rab effector protein and play a role in vesicle trafficking. Interacts with RAB27A. keratinocyte development protein binding endosome intracellular protein transport Rab GTPase binding positive regulation of exocytosis positive regulation of protein secretion multivesicular body sorting pathway uc009pma.1 uc009pma.2 uc009pma.3 uc009pma.4 
ENSMUST00000051017.9 Defb1 ENSMUST00000051017.9 defensin beta 1 (from RefSeq NM_007843.3) Defb1 ENSMUST00000051017.1 ENSMUST00000051017.2 ENSMUST00000051017.3 ENSMUST00000051017.4 ENSMUST00000051017.5 ENSMUST00000051017.6 ENSMUST00000051017.7 ENSMUST00000051017.8 NM_007843 Q3UQE2 Q3UQE2_MOUSE uc009lby.1 uc009lby.2 uc009lby.3 uc009lby.4 Membrane Secreted Belongs to the beta-defensin family. acute inflammatory response extracellular region defense response response to testosterone uc009lby.1 uc009lby.2 uc009lby.3 uc009lby.4 
ENSMUST00000051025.5 Tmem102 ENSMUST00000051025.5 transmembrane protein 102 (from RefSeq NM_001033433.4) E9Q2B4 ENSMUST00000051025.1 ENSMUST00000051025.2 ENSMUST00000051025.3 ENSMUST00000051025.4 NM_001033433 Q3UPR7 TM102_MOUSE uc007jrs.1 uc007jrs.2 uc007jrs.3 uc007jrs.4 Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. Interacts with CSF2RB; this interaction occurs preferentially in the absence of CSF2. Cell membrane ; Single-pass membrane protein Note=Also located in intracellular compartments. molecular_function mitochondrion plasma membrane apoptotic process signal transduction cell surface positive regulation of T cell chemotaxis membrane integral component of membrane macromolecular complex response to cytokine regulation of apoptotic process positive regulation of cell adhesion regulation of peptidyl-tyrosine phosphorylation regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway positive regulation of T cell migration uc007jrs.1 uc007jrs.2 uc007jrs.3 uc007jrs.4 
ENSMUST00000051053.5 Ubtd2 ENSMUST00000051053.5 ubiquitin domain containing 2, transcript variant 1 (from RefSeq NM_173784.4) A2AAY6 ENSMUST00000051053.1 ENSMUST00000051053.2 ENSMUST00000051053.3 ENSMUST00000051053.4 NM_173784 Q6PGH0 Q8C5Y1 UBTD2_MOUSE uc007ijr.1 uc007ijr.2 uc007ijr.3 Cytoplasm molecular_function cytoplasm biological_process uc007ijr.1 uc007ijr.2 uc007ijr.3 
ENSMUST00000051064.9 Zc2hc1a ENSMUST00000051064.9 zinc finger, C2HC-type containing 1A (from RefSeq NM_173181.3) ENSMUST00000051064.1 ENSMUST00000051064.2 ENSMUST00000051064.3 ENSMUST00000051064.4 ENSMUST00000051064.5 ENSMUST00000051064.6 ENSMUST00000051064.7 ENSMUST00000051064.8 Fam164a NM_173181 Q3TCP6 Q8BJH1 ZC21A_MOUSE uc008oog.1 uc008oog.2 uc008oog.3 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BJH1-1; Sequence=Displayed; Name=2; IsoId=Q8BJH1-2; Sequence=VSP_023580; Belongs to the ZC2HC1 family. molecular_function cellular_component biological_process metal ion binding uc008oog.1 uc008oog.2 uc008oog.3 
ENSMUST00000051065.6 Gprin3 ENSMUST00000051065.6 GPRIN family member 3 (from RefSeq NM_183183.3) ENSMUST00000051065.1 ENSMUST00000051065.2 ENSMUST00000051065.3 ENSMUST00000051065.4 ENSMUST00000051065.5 GRIN3_MOUSE Kiaa2027 NM_183183 Q69Z30 Q8BWS5 uc009cdk.1 uc009cdk.2 uc009cdk.3 May be involved in neurite outgrowth. Sequence=BAD32614.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc009cdk.1 uc009cdk.2 uc009cdk.3 
ENSMUST00000051079.4 Gphb5 ENSMUST00000051079.4 glycoprotein hormone beta 5 (from RefSeq NM_175644.3) ENSMUST00000051079.1 ENSMUST00000051079.2 ENSMUST00000051079.3 GPHB5_MOUSE Gpb5 NM_175644 Q812B2 Q8BJV2 Zlut1 uc007nxd.1 uc007nxd.2 uc007nxd.3 Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. Heterodimer with GPHA2; this heterodimer interacts with thyroid-stimulating hormone receptor (TSHR), and hence stimulates cAMP production. Secreted Expressed in the anterior lobe of pituitary. N-glycosylated. Overexpression of Gphb5 results in proptosis, elevated serum T4 levels and significantly reduced body weight. Belongs to the glycoprotein hormones subunit beta family. Sequence=AK078727; Type=Frameshift; Evidence=; regulation of thyroid hormone mediated signaling pathway hormone activity extracellular region extracellular space cytoplasm G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway hormone-mediated signaling pathway thyrotropin-releasing hormone receptor binding protein heterodimerization activity uc007nxd.1 uc007nxd.2 uc007nxd.3 
ENSMUST00000051089.4 Gm42743 ENSMUST00000051089.4 Gm42743 (from geneSymbol) BC019122 ENSMUST00000051089.1 ENSMUST00000051089.2 ENSMUST00000051089.3 uc290htw.1 uc290htw.2 uc290htw.1 uc290htw.2 
ENSMUST00000051091.5 H2bc6 ENSMUST00000051091.5 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (from UniProt Q6ZWY9) AK030546 ENSMUST00000051091.1 ENSMUST00000051091.2 ENSMUST00000051091.3 ENSMUST00000051091.4 H2B1C_MOUSE H2bc4 H2bc6 H2bc8 Hist1h2bc Hist1h2be Hist1h2bg Q6ZWY9 uc007pui.1 uc007pui.2 uc007pui.3 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome innate immune response in mucosa DNA binding extracellular space nucleus nucleoplasm chromosome cytosol nucleosome assembly antibacterial humoral response identical protein binding protein heterodimerization activity defense response to Gram-positive bacterium uc007pui.1 uc007pui.2 uc007pui.3 
ENSMUST00000051094.9 Golga7 ENSMUST00000051094.9 golgin A7, transcript variant 2 (from RefSeq NM_001042484.1) ENSMUST00000051094.1 ENSMUST00000051094.2 ENSMUST00000051094.3 ENSMUST00000051094.4 ENSMUST00000051094.5 ENSMUST00000051094.6 ENSMUST00000051094.7 ENSMUST00000051094.8 GOGA7_MOUSE MNCb-1213 NM_001042484 Q8BN18 Q91W53 Q9JJE0 uc009les.1 uc009les.2 uc009les.3 May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (By similarity). Interacts with GOLGA3. Interacts with ZDHHC9 (By similarity). Golgi apparatus membrane ; Lipid- anchor Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91W53-1; Sequence=Displayed; Name=2; IsoId=Q91W53-2; Sequence=VSP_016281; Palmitoylated on Cys-69 and Cys-72; which is required for Golgi localization and interaction with GOLGA3. Belongs to the ERF4 family. Sequence=BAA95052.1; Type=Frameshift; Evidence=; Golgi membrane palmitoyltransferase complex Golgi apparatus Golgi stack protein targeting to membrane Golgi to plasma membrane transport membrane peptidyl-L-cysteine S-palmitoylation intrinsic component of Golgi membrane Golgi to plasma membrane protein transport protein stabilization protein-cysteine S-palmitoyltransferase activity uc009les.1 uc009les.2 uc009les.3 
ENSMUST00000051097.6 Prss50 ENSMUST00000051097.6 serine protease 50, transcript variant 1 (from RefSeq NM_146227.4) B2RWS9 ENSMUST00000051097.1 ENSMUST00000051097.2 ENSMUST00000051097.3 ENSMUST00000051097.4 ENSMUST00000051097.5 NM_146227 Q8BLH5 Q8K466 TSP50_MOUSE Tsp50 uc009rva.1 uc009rva.2 uc009rva.3 May be involved in proteolysis through its threonine endopeptidase activity. Membrane ; Single-pass type I membrane protein Belongs to the peptidase S1 family. Although related to peptidase S1 family, lacks the conserved active Ser residue in position 364 which is replaced by a Thr. serine-type endopeptidase activity threonine-type endopeptidase activity cytoplasm endoplasmic reticulum proteolysis peptidase activity membrane integral component of membrane hydrolase activity uc009rva.1 uc009rva.2 uc009rva.3 
ENSMUST00000051103.3 Krtap19-4 ENSMUST00000051103.3 keratin associated protein 19-4 (from RefSeq NM_130873.1) ENSMUST00000051103.1 ENSMUST00000051103.2 KR194_MOUSE Krtap16-4 Krtap16.4 NM_130873 Q925H7 uc007zvk.1 uc007zvk.2 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Strong expression in narrowly defined pattern restricted to the lower and middle cortical regions of the hair shaft in both developing and cycling hair. During hair follicle regression (catagen), expression levels decrease until expression is no longer detectable in follicles at resting stage (telogen). Expression in skin and hair follicle is regulated by HOXC13 and by GATA3. Belongs to the KRTAP type 19 family. molecular_function cellular_component intermediate filament biological_process uc007zvk.1 uc007zvk.2 
ENSMUST00000051117.3 Ccdc121rt3 ENSMUST00000051117.3 coiled-coil domain containing 121, retrogene 3 (from RefSeq NM_001039228.4) Ccdc121rt3 E9Q8Z1 E9Q8Z1_MOUSE ENSMUST00000051117.1 ENSMUST00000051117.2 NM_001039228 uc008ytg.1 uc008ytg.2 uc008ytg.3 uc008ytg.4 molecular_function cellular_component biological_process uc008ytg.1 uc008ytg.2 uc008ytg.3 uc008ytg.4 
ENSMUST00000051118.7 Tvp23a ENSMUST00000051118.7 trans-golgi network vesicle protein 23A, transcript variant 2 (from RefSeq NM_001359069.1) BC068110 ENSMUST00000051118.1 ENSMUST00000051118.2 ENSMUST00000051118.3 ENSMUST00000051118.4 ENSMUST00000051118.5 ENSMUST00000051118.6 Fam18a NM_001359069 Q6NVH0 Q6NVH0_MOUSE Tvp23a uc007ydp.1 uc007ydp.2 uc007ydp.3 uc007ydp.4 Membrane ulti-pass membrane protein Belongs to the TVP23 family. molecular_function protein secretion membrane integral component of membrane vesicle-mediated transport integral component of Golgi membrane uc007ydp.1 uc007ydp.2 uc007ydp.3 uc007ydp.4 
ENSMUST00000051126.4 Pcdhb10 ENSMUST00000051126.4 protocadherin beta 10 (from RefSeq NM_053135.2) ENSMUST00000051126.1 ENSMUST00000051126.2 ENSMUST00000051126.3 NM_053135 Pcdhb10 Pcdhb5d Q91VE5 Q91VE5_MOUSE uc008epv.1 uc008epv.2 uc008epv.3 molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epv.1 uc008epv.2 uc008epv.3 
ENSMUST00000051129.10 Lrrc75b ENSMUST00000051129.10 leucine rich repeat containing 75B (from RefSeq NM_198860.2) ENSMUST00000051129.1 ENSMUST00000051129.2 ENSMUST00000051129.3 ENSMUST00000051129.4 ENSMUST00000051129.5 ENSMUST00000051129.6 ENSMUST00000051129.7 ENSMUST00000051129.8 ENSMUST00000051129.9 Fam211b LR75B_MOUSE Lrrc75b NM_198860 Q3V1Q4 Q7TPD7 uc029qyw.1 uc029qyw.2 May suppress myogenic differentiation by modulating MYOG expression and Erk1/2 signaling. Markedly decreased during differentiation. Belongs to the LRRC75 family. molecular_function cellular_component biological_process uc029qyw.1 uc029qyw.2 
ENSMUST00000051133.6 Taar8a ENSMUST00000051133.6 trace amine-associated receptor 8A (from RefSeq NM_001010830.1) ENSMUST00000051133.1 ENSMUST00000051133.2 ENSMUST00000051133.3 ENSMUST00000051133.4 ENSMUST00000051133.5 Gm230 NM_001010830 Q5QD07 TAA8A_MOUSE uc007eqo.1 uc007eqo.2 Orphan olfactory receptor specific for trace amines. Cell membrane ; Multi-pass membrane protein Specifically expressed in neurons of the olfactory epithelium. Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2- phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled amine receptor activity membrane integral component of membrane uc007eqo.1 uc007eqo.2 
ENSMUST00000051137.15 Olfm5 ENSMUST00000051137.15 olfactomedin 5 (from RefSeq NM_172905.2) E030002O03Rik ENSMUST00000051137.1 ENSMUST00000051137.10 ENSMUST00000051137.11 ENSMUST00000051137.12 ENSMUST00000051137.13 ENSMUST00000051137.14 ENSMUST00000051137.2 ENSMUST00000051137.3 ENSMUST00000051137.4 ENSMUST00000051137.5 ENSMUST00000051137.6 ENSMUST00000051137.7 ENSMUST00000051137.8 ENSMUST00000051137.9 NM_172905 Olfm5 Q8BU90 Q8BU90_MOUSE uc009ivm.1 uc009ivm.2 uc009ivm.3 Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function cellular_component biological_process uc009ivm.1 uc009ivm.2 uc009ivm.3 
ENSMUST00000051139.13 Rsbn1 ENSMUST00000051139.13 rosbin, round spermatid basic protein 1, transcript variant 2 (from RefSeq NM_001356556.1) B0V3N6 B9EI66 ENSMUST00000051139.1 ENSMUST00000051139.10 ENSMUST00000051139.11 ENSMUST00000051139.12 ENSMUST00000051139.2 ENSMUST00000051139.3 ENSMUST00000051139.4 ENSMUST00000051139.5 ENSMUST00000051139.6 ENSMUST00000051139.7 ENSMUST00000051139.8 ENSMUST00000051139.9 Kiaa3002 NM_001356556 Q3UUB5 Q4VC18 Q7TNJ3 Q80T69 Q8C2Z3 RSBN1_MOUSE Rsbn uc008qtw.1 uc008qtw.2 Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Nucleus Testis. Expressed exclusively in haploid round spermatids. Expressed abundantly in the testis at 23 days after birth and later. Expressed exclusively in the germ cells. Phosphorylated by PKA. Belongs to the round spermatid basic protein 1 family. Sequence=AAH94667.1; Type=Erroneous initiation; Evidence=; Sequence=BAC39967.1; Type=Erroneous initiation; Evidence=; Sequence=BAE23712.1; Type=Erroneous initiation; Evidence=; Sequence=CAQ12904.1; Type=Erroneous initiation; Evidence=; protein binding nucleus chromatin organization biological_process oxidoreductase activity metal ion binding dioxygenase activity oxidation-reduction process uc008qtw.1 uc008qtw.2 
ENSMUST00000051145.15 Wdr47 ENSMUST00000051145.15 WD repeat domain 47, transcript variant 1 (from RefSeq NM_181400.3) A2AGC7 ENSMUST00000051145.1 ENSMUST00000051145.10 ENSMUST00000051145.11 ENSMUST00000051145.12 ENSMUST00000051145.13 ENSMUST00000051145.14 ENSMUST00000051145.2 ENSMUST00000051145.3 ENSMUST00000051145.4 ENSMUST00000051145.5 ENSMUST00000051145.6 ENSMUST00000051145.7 ENSMUST00000051145.8 ENSMUST00000051145.9 Kiaa0893 NM_181400 Q80TP4 Q8CGF6 WDR47_MOUSE uc008qzj.1 uc008qzj.2 uc008qzj.3 uc008qzj.4 Interacts with MAP1S (via WD repeats). Cytoplasm, cytoskeleton Note=Localization along microtubules is mediated by MAP1S. Enriched in the nervous system (at protein level). First detected in whole embryos at 11 dpc, strong and increasing protein levels are observed in the brain from 14 dpc to early postnatal development. Expression continues into adulthood, though at a substantially decreased level. Sequence=BAC65679.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component cytoplasm cytoskeleton microtubule multicellular organism development biological_process uc008qzj.1 uc008qzj.2 uc008qzj.3 uc008qzj.4 
ENSMUST00000051153.6 3300002I08Rik ENSMUST00000051153.6 RIKEN cDNA 3300002I08 gene (from RefSeq NM_027017.1) 3300002I08Rik ENSMUST00000051153.1 ENSMUST00000051153.2 ENSMUST00000051153.3 ENSMUST00000051153.4 ENSMUST00000051153.5 NM_027017 Q9CXH3 Q9CXH3_MOUSE uc008mtz.1 uc008mtz.2 uc008mtz.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process uc008mtz.1 uc008mtz.2 uc008mtz.3 
ENSMUST00000051159.3 Prop1 ENSMUST00000051159.3 paired like homeodomain factor 1 (from RefSeq NM_008936.2) ENSMUST00000051159.1 ENSMUST00000051159.2 NM_008936 P97458 PROP1_MOUSE Prop-1 Q5NCG9 uc007itg.1 uc007itg.2 uc007itg.3 Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes. P97458; Q02248: Ctnnb1; NbExp=2; IntAct=EBI-937831, EBI-397872; Nucleus Belongs to the paired homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding blood vessel development DNA binding chromatin binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated beta-catenin binding protein C-terminus binding animal organ morphogenesis dorsal/ventral pattern formation cell migration hypothalamus cell differentiation pituitary gland development adenohypophysis development negative regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter gland development hypophysis morphogenesis canonical Wnt signaling pathway somatotropin secreting cell differentiation uc007itg.1 uc007itg.2 uc007itg.3 
ENSMUST00000051163.3 Pcdhb8 ENSMUST00000051163.3 protocadherin beta 8 (from RefSeq NM_053133.1) ENSMUST00000051163.1 ENSMUST00000051163.2 NM_053133 PCDB8_MOUSE Pcdhb8 Q91XZ2 uc008ept.1 uc008ept.2 uc008ept.3 Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (Probable). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523). Forms homodimers in trans (molecules expressed by two different cells) (PubMed:27161523). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins (PubMed:27161523). Cell membrane ; Single-pass type I membrane protein Cadherin 1 to cadherin 4 domains mediate homophilic trans- interaction, the interaction with an identical protocadherin expressed by a neighboring cell (PubMed:27161523). This is a head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin (PubMed:27161523). The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane (PubMed:27161523). Each cadherin domain binds three calcium ions (PubMed:27161523). calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane identical protein binding metal ion binding uc008ept.1 uc008ept.2 uc008ept.3 
ENSMUST00000051176.9 Fam180a ENSMUST00000051176.9 family with sequence similarity 180, member A (from RefSeq NM_173375.2) ENSMUST00000051176.1 ENSMUST00000051176.2 ENSMUST00000051176.3 ENSMUST00000051176.4 ENSMUST00000051176.5 ENSMUST00000051176.6 ENSMUST00000051176.7 ENSMUST00000051176.8 F180A_MOUSE NM_173375 Q8BR21 uc009bir.1 uc009bir.2 uc009bir.3 Secreted Belongs to the FAM180 family. molecular_function cellular_component extracellular region biological_process uc009bir.1 uc009bir.2 uc009bir.3 
ENSMUST00000051179.12 Fam181b ENSMUST00000051179.12 family with sequence similarity 181, member B (from RefSeq NM_021427.2) A0A140LHM6 A0A140LHM6_MOUSE ENSMUST00000051179.1 ENSMUST00000051179.10 ENSMUST00000051179.11 ENSMUST00000051179.2 ENSMUST00000051179.3 ENSMUST00000051179.4 ENSMUST00000051179.5 ENSMUST00000051179.6 ENSMUST00000051179.7 ENSMUST00000051179.8 ENSMUST00000051179.9 Fam181b NM_021427 uc291ssf.1 uc291ssf.2 uc291ssf.1 uc291ssf.2 
ENSMUST00000051184.10 Kcnrg ENSMUST00000051184.10 potassium channel regulator, transcript variant 1 (from RefSeq NM_001039105.4) B2RV87 B7ZWD9 Clld4 ENSMUST00000051184.1 ENSMUST00000051184.2 ENSMUST00000051184.3 ENSMUST00000051184.4 ENSMUST00000051184.5 ENSMUST00000051184.6 ENSMUST00000051184.7 ENSMUST00000051184.8 ENSMUST00000051184.9 KCNRG_MOUSE NM_001039105 Q2TUM3 Q6P8J6 Q8C6V1 uc007uge.1 uc007uge.2 uc007uge.3 uc007uge.4 Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (By similarity). Can form homooligomers. Interacts with KCNA1 (via cytoplasmic N-terminal domain) and KCNA4. Endoplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2TUM3-1; Sequence=Displayed; Name=2; IsoId=Q2TUM3-3; Sequence=VSP_019023, VSP_019024; endoplasmic reticulum identical protein binding protein homooligomerization negative regulation of delayed rectifier potassium channel activity uc007uge.1 uc007uge.2 uc007uge.3 uc007uge.4 
ENSMUST00000051186.9 Prkaa1 ENSMUST00000051186.9 protein kinase, AMP-activated, alpha 1 catalytic subunit, transcript variant 2 (from RefSeq NM_001355640.1) AAPK1_MOUSE ENSMUST00000051186.1 ENSMUST00000051186.2 ENSMUST00000051186.3 ENSMUST00000051186.4 ENSMUST00000051186.5 ENSMUST00000051186.6 ENSMUST00000051186.7 ENSMUST00000051186.8 NM_001355640 Q5EG47 uc007vct.1 uc007vct.2 Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (By similarity). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (By similarity). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (By similarity). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:15878856). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (PubMed:16804075, PubMed:16804077). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:16148943, PubMed:16308421, PubMed:20647423, PubMed:21459323). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (PubMed:16148943, PubMed:16308421). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (PubMed:20647423). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:18439900, PubMed:21258367, PubMed:21205641, PubMed:32912901). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (By similarity). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (By similarity). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21258367, PubMed:21205641). In that process also activates WDR45/WIPI4 (By similarity). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (By similarity). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (PubMed:23283301). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (By similarity). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (PubMed:19833968). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (PubMed:20361929). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (By similarity). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O- phospho-L-seryl-[acetyl-CoA carboxylase]; Xref=Rhea:RHEA:20333, Rhea:RHEA-COMP:13722, Rhea:RHEA-COMP:13723, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; Evidence=; Reaction=ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3- methylglutaryl-coenzyme A reductase]; Xref=Rhea:RHEA:23172, Rhea:RHEA-COMP:13692, Rhea:RHEA-COMP:13693, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.31; Evidence=; Reaction=ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl- [tau protein]; Xref=Rhea:RHEA:12801, Rhea:RHEA-COMP:13701, Rhea:RHEA- COMP:13702, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.26; Evidence=; Reaction=ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L- threonyl-[tau protein]; Xref=Rhea:RHEA:53904, Rhea:RHEA-COMP:13703, Rhea:RHEA-COMP:13704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.26; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation on Thr-183. Binding of AMP to non-catalytic gamma subunit (PRKAG1, PRKAG2 or PRKAG3) results in allosteric activation, inducing phosphorylation on Thr-183. AMP-binding to gamma subunit also sustains activity by preventing dephosphorylation of Thr-183. ADP also stimulates Thr-183 phosphorylation, without stimulating already phosphorylated AMPK. ATP promotes dephosphorylation of Thr-183, rendering the enzyme inactive. Under physiological conditions AMPK mainly exists in its inactive form in complex with ATP, which is much more abundant than AMP. Selectively inhibited by compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3- pyridin-4-yl-pyyrazolo[1,5-a] pyrimidine. Activated by resveratrol, a natural polyphenol present in red wine, and S17834, a synthetic polyphenol. AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2. Q5EG47; P46937: YAP1; Xeno; NbExp=2; IntAct=EBI-7282395, EBI-1044059; Cytoplasm Nucleus Note=In response to stress, recruited by p53/TP53 to specific promoters. The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity. Phosphorylated at Thr-183 by STK11/LKB1 in complex with STE20- related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-183 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-183, but at a much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. Dephosphorylated by PPM1A and PPM1B (By similarity). Ubiquitinated. Glycosylated; O-GlcNAcylated by OGT, promoting the AMP-activated protein kinase (AMPK) activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. nucleotide binding chromatin binding protein kinase activity protein serine/threonine kinase activity AMP-activated protein kinase activity protein binding ATP binding nucleus cytoplasm cytosol glucose metabolic process chromatin organization protein phosphorylation lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process steroid biosynthetic process cholesterol biosynthetic process autophagy protein C-terminus binding steroid metabolic process cholesterol metabolic process positive regulation of cell proliferation lipid biosynthetic process response to UV cold acclimation response to gamma radiation positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression response to activity Wnt signaling pathway sterol biosynthetic process kinase activity phosphorylation apical plasma membrane nuclear speck transferase activity fatty acid oxidation kinase binding axon dendrite response to caffeine nucleotide-activated protein kinase complex cellular response to nutrient levels negative regulation of TOR signaling macromolecular complex regulation of peptidyl-serine phosphorylation cellular response to oxidative stress histone serine kinase activity histone-serine phosphorylation intracellular signal transduction cellular response to glucose starvation response to hydrogen peroxide glucose homeostasis regulation of circadian rhythm neuronal cell body negative regulation of apoptotic process positive regulation of glycolytic process negative regulation of insulin receptor signaling pathway metal ion binding [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity rhythmic process positive regulation of skeletal muscle tissue development tau-protein kinase activity [acetyl-CoA carboxylase] kinase activity negative regulation of lipid catabolic process protein heterooligomerization fatty acid homeostasis regulation of vesicle-mediated transport motor behavior CAMKK-AMPK signaling cascade neuron cellular homeostasis cellular response to hydrogen peroxide regulation of microtubule cytoskeleton organization cellular response to calcium ion cellular response to glucose stimulus cellular response to ethanol cellular response to prostaglandin E stimulus cellular response to organonitrogen compound cellular response to hypoxia energy homeostasis response to camptothecin positive regulation of transcription from mitochondrial promoter positive regulation of cellular protein localization positive regulation of protein targeting to mitochondrion negative regulation of tubulin deacetylation positive regulation of peptidyl-lysine acetylation uc007vct.1 uc007vct.2 
ENSMUST00000051201.7 Or55b4 ENSMUST00000051201.7 olfactory receptor family 55 subfamily B member 4 (from RefSeq NM_020289.2) E9PX47 E9PX47_MOUSE ENSMUST00000051201.1 ENSMUST00000051201.2 ENSMUST00000051201.3 ENSMUST00000051201.4 ENSMUST00000051201.5 ENSMUST00000051201.6 NM_020289 Olfr544 Or55b4 uc009irs.1 uc009irs.2 uc009irs.3 uc009irs.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DR065630.1, DR065624.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009irs.1 uc009irs.2 uc009irs.3 uc009irs.4 
ENSMUST00000051207.2 Slc35e4 ENSMUST00000051207.2 solute carrier family 35, member E4 (from RefSeq NM_153142.3) A0A0R4J0N3 A0A0R4J0N3_MOUSE ENSMUST00000051207.1 NM_153142 Slc35e4 uc007htv.1 uc007htv.2 Membrane ; Multi- pass membrane protein membrane integral component of membrane uc007htv.1 uc007htv.2 
ENSMUST00000051209.11 Peg3 ENSMUST00000051209.11 paternally expressed 3, transcript variant 1 (from RefSeq NM_008817.3) ENSMUST00000051209.1 ENSMUST00000051209.10 ENSMUST00000051209.2 ENSMUST00000051209.3 ENSMUST00000051209.4 ENSMUST00000051209.5 ENSMUST00000051209.6 ENSMUST00000051209.7 ENSMUST00000051209.8 ENSMUST00000051209.9 Kiaa0287 NM_008817 O54978 PEG3_MOUSE Pw1 Q3TQ69 Q3URU2 Q5EBP7 Q61138 Q6GQS0 Q80U47 Q8R5N0 Q9QX53 uc009fbw.1 uc009fbw.2 uc009fbw.3 Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Plays a role in regulating maternal behavior and offspring growth. Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2. Nucleus. Cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3URU2-1; Sequence=Displayed; Name=2; IsoId=Q3URU2-2; Sequence=VSP_020375, VSP_020376, VSP_020377; Brain, glial cells, neurons, skeletal muscle, uterus and placenta. In the placenta it is found in all trophoblast cells. Strongly expressed upon gastrulation and subsequently becomes restricted to skeletal muscle and subregions of the CNS. At 9.5 dpc, expressed in the branchial arches, somites and gut but little in the heart and neural tissues. At 12.5 dpc strongly expressed in the cranial skeleton, tongue, vertebral cartilage, pituitary and the luminal epithelium. Induced during p53/TP53 mediated apoptosis. Up-regulated by DNA damage in cortical neurons in the presence of p53/TP53. The SCAN domain enables PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAC52770.1; Type=Frameshift; Evidence=; Sequence=BAB85589.1; Type=Frameshift; Evidence=; Sequence=BAC65520.2; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleic acid binding nucleus cytoplasm autophagosome apoptotic process regulation of gene expression positive regulation of transcription from RNA polymerase II promoter metal ion binding uc009fbw.1 uc009fbw.2 uc009fbw.3 
ENSMUST00000051224.8 Stk-ps2 ENSMUST00000051224.8 Stk-ps2 (from geneSymbol) AK029722 ENSMUST00000051224.1 ENSMUST00000051224.2 ENSMUST00000051224.3 ENSMUST00000051224.4 ENSMUST00000051224.5 ENSMUST00000051224.6 ENSMUST00000051224.7 uc011wkm.1 uc011wkm.2 uc011wkm.3 uc011wkm.1 uc011wkm.2 uc011wkm.3 
ENSMUST00000051239.13 Sptssb ENSMUST00000051239.13 serine palmitoyltransferase, small subunit B, transcript variant 2 (from RefSeq NM_133675.3) Admp ENSMUST00000051239.1 ENSMUST00000051239.10 ENSMUST00000051239.11 ENSMUST00000051239.12 ENSMUST00000051239.2 ENSMUST00000051239.3 ENSMUST00000051239.4 ENSMUST00000051239.5 ENSMUST00000051239.6 ENSMUST00000051239.7 ENSMUST00000051239.8 ENSMUST00000051239.9 NM_133675 Q925E8 SPTSB_MOUSE Sssptb uc033huh.1 uc033huh.2 uc033huh.3 Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Lipid metabolism; sphingolipid metabolism. Component of the serine palmitoyltransferase (SPT) complex, which is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. The heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core of the enzyme, while SPTSSA or SPTSSB subunits determine substrate specificity (By similarity). SPT also interacts with ORMDL proteins, especially ORMDL3, which negatively regulate SPT activity in the presence of ceramides (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Expression is strong in hypogonadal (hpg) mouse prostate, weak in mature castrated mouse prostate and absent in normal intact or androgen-replaced hpg mouse prostates. While expression is androgen independent in the hpg mouse prostate, it appears to be androgen-dependent in the kidney and brain of normal intact mouse suggesting tissue specific regulation by androgens. Belongs to the SPTSS family. SPTSSB subfamily. serine C-palmitoyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process sphingolipid metabolic process endoplasmic reticulum organization membrane integral component of membrane serine C-palmitoyltransferase complex sphingolipid biosynthetic process ceramide biosynthetic process regulation of serine C-palmitoyltransferase activity uc033huh.1 uc033huh.2 uc033huh.3 
ENSMUST00000051241.7 Zfp36 ENSMUST00000051241.7 zinc finger protein 36 (from RefSeq NM_011756.5) ENSMUST00000051241.1 ENSMUST00000051241.2 ENSMUST00000051241.3 ENSMUST00000051241.4 ENSMUST00000051241.5 ENSMUST00000051241.6 NM_011756 Q3U3D2 Q3U3D2_MOUSE Zfp36 uc009fys.1 uc009fys.2 uc009fys.3 Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'- untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE- containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes. Cytoplasmic granule Nucleus Cytoplasm metal ion binding uc009fys.1 uc009fys.2 uc009fys.3 
ENSMUST00000051256.10 Armcx1 ENSMUST00000051256.10 armadillo repeat containing, X-linked 1, transcript variant 4 (from RefSeq NM_001166379.1) ARMX1_MOUSE ENSMUST00000051256.1 ENSMUST00000051256.2 ENSMUST00000051256.3 ENSMUST00000051256.4 ENSMUST00000051256.5 ENSMUST00000051256.6 ENSMUST00000051256.7 ENSMUST00000051256.8 ENSMUST00000051256.9 NM_001166379 Q9CX83 uc009ugm.1 uc009ugm.2 uc009ugm.3 uc009ugm.4 uc009ugm.5 Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with Miro1. Interacts with MIRO1. Mitochondrion tochondrion outer membrane ; Single-pass membrane protein Widely expressed in the adult nervous tissue, especially in the forebrain, including the cerebral cortex, hippocampus and thalamus. After axonal injury. Belongs to the eutherian X-chromosome-specific Armcx family. molecular_function cellular_component mitochondrion mitochondrial outer membrane biological_process membrane integral component of membrane uc009ugm.1 uc009ugm.2 uc009ugm.3 uc009ugm.4 uc009ugm.5 
ENSMUST00000051259.10 Adgrg3 ENSMUST00000051259.10 adhesion G protein-coupled receptor G3 (from RefSeq NM_173036.3) AGRG3_MOUSE ENSMUST00000051259.1 ENSMUST00000051259.2 ENSMUST00000051259.3 ENSMUST00000051259.4 ENSMUST00000051259.5 ENSMUST00000051259.6 ENSMUST00000051259.7 ENSMUST00000051259.8 ENSMUST00000051259.9 Gpr97 NM_173036 Q3U2Q3 Q8R0T6 uc009mxp.1 uc009mxp.2 uc009mxp.3 uc009mxp.4 Orphan receptor that regulates migration of lymphatic endothelial cells via the small GTPases RhoA and CDC42 (By similarity). Regulates B-cell development (PubMed:24113187). Seems to signal through G-alpha(q)-proteins (By similarity). Membrane ; Multi- pass membrane protein Specifically expressed in intestinal lymphatic endothelium. No visible phenotype. Mutant mice show altered follicular-versus-marginal zone B-lymphocyte fate decision in the spleen and decreased numbers of B220+ lymphocytes in the bone marrow. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. transmembrane signaling receptor activity G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway membrane integral component of membrane B cell differentiation regulation of cell migration negative regulation of CREB transcription factor activity negative regulation of NIK/NF-kappaB signaling uc009mxp.1 uc009mxp.2 uc009mxp.3 uc009mxp.4 
ENSMUST00000051272.8 Wfdc12 ENSMUST00000051272.8 WAP four-disulfide core domain 12 (from RefSeq NM_138684.3) ENSMUST00000051272.1 ENSMUST00000051272.2 ENSMUST00000051272.3 ENSMUST00000051272.4 ENSMUST00000051272.5 ENSMUST00000051272.6 ENSMUST00000051272.7 NM_138684 Q9JHY3 Swam2 WFD12_MOUSE Wfdc12 uc008ntx.1 uc008ntx.2 uc008ntx.3 Antibacterial protein which inhibits the growth of E.coli and S.aureus. Putative acid-stable proteinase inhibitor. Secreted Constitutively expressed in tongue. molecular_function serine-type endopeptidase inhibitor activity cellular_component extracellular region negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity defense response to bacterium uc008ntx.1 uc008ntx.2 uc008ntx.3 
ENSMUST00000051277.4 Prlhr ENSMUST00000051277.4 prolactin releasing hormone receptor (from RefSeq NM_201615.2) E9QJU3 ENSMUST00000051277.1 ENSMUST00000051277.2 ENSMUST00000051277.3 Gm339 Gpr10 NM_201615 PRLHR_MOUSE Q059H6 Q6VMN6 uc008ibu.1 uc008ibu.2 uc008ibu.3 uc008ibu.4 Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing. Interacts through its C-terminal region with the PDZ domain- containing proteins GRIP1, GRIP2 and PICK1. Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1 (By similarity). Cell membrane; Multi-pass membrane protein. Increased nociceptive thresholds, increased stress-induced analgesia and reduced morphine tolerance. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity neuropeptide Y receptor activity plasma membrane cilium signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway feeding behavior membrane integral component of membrane peptide hormone binding hormone metabolic process uc008ibu.1 uc008ibu.2 uc008ibu.3 uc008ibu.4 
ENSMUST00000051283.8 Clec2m ENSMUST00000051283.8 C-type lectin domain family 2, member m (from RefSeq NM_199034.4) 4922502D21Rik Clec2m ENSMUST00000051283.1 ENSMUST00000051283.2 ENSMUST00000051283.3 ENSMUST00000051283.4 ENSMUST00000051283.5 ENSMUST00000051283.6 ENSMUST00000051283.7 NM_199034 Q8C634 Q8C634_MOUSE uc009efk.1 uc009efk.2 uc009efk.3 Membrane ; Single- pass type II membrane protein molecular_function cellular_component biological_process membrane integral component of membrane carbohydrate binding uc009efk.1 uc009efk.2 uc009efk.3 
ENSMUST00000051293.8 Gpr146 ENSMUST00000051293.8 G protein-coupled receptor 146, transcript variant 1 (from RefSeq NM_030258.5) ENSMUST00000051293.1 ENSMUST00000051293.2 ENSMUST00000051293.3 ENSMUST00000051293.4 ENSMUST00000051293.5 ENSMUST00000051293.6 ENSMUST00000051293.7 GP146_MOUSE NM_030258 Q3U3K8 Q3U421 Q8BHR6 Q8BHU4 Q99LE2 uc009agm.1 uc009agm.2 uc009agm.3 uc009agm.4 Orphan receptor. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane uc009agm.1 uc009agm.2 uc009agm.3 uc009agm.4 
ENSMUST00000051297.9 Tnp2 ENSMUST00000051297.9 transition protein 2 (from RefSeq NM_013694.4) ENSMUST00000051297.1 ENSMUST00000051297.2 ENSMUST00000051297.3 ENSMUST00000051297.4 ENSMUST00000051297.5 ENSMUST00000051297.6 ENSMUST00000051297.7 ENSMUST00000051297.8 NM_013694 P11378 Q91XK4 STP2_MOUSE Tnp2 uc007yee.1 uc007yee.2 uc007yee.3 Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:15163613, PubMed:15189834, PubMed:15083521, PubMed:28366643). In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). The histone H2AB1-H2BC1/TH2B dimer is required for loading of TNP2 onto chromatin (PubMed:28366643). Nucleus Chromosome Note=Loaded onto the nucleosomes of condensing spermatids (PubMed:28366643). Inclusion of the H2AB1- H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition protein TNP2 (PubMed:28366643). Nuclear import is mediated by IPO4. Nucleolar localization requires the protein to be phosphorylated (By similarity). Appears in elongating/condensing spermatids when histones are still detectable (PubMed:15163613). Coexpressed with H2ab1 during late spermiogenesis (PubMed:28366643). Male mice lacking both Tnp1 and Tnp2 are completely infertile, but protamine alone are capable of histone eviction (PubMed:15163613, PubMed:15189834, PubMed:15083521). A significant proportion of Prm2 remains unprocessed (PubMed:15163613, PubMed:15189834, PubMed:15083521). Chromatin in mature spermatozoa shows defects in density (PubMed:15189834, PubMed:15083521). Belongs to the nuclear transition protein 2 family. Sequence=AAA40468.1; Type=Erroneous initiation; Evidence=; nucleosome nuclear nucleosome male germ cell nucleus DNA binding nucleus chromosome multicellular organism development spermatogenesis binding of sperm to zona pellucida acrosome reaction penetration of zona pellucida zinc ion binding positive regulation of protein processing cell differentiation flagellated sperm motility spermatogenesis, exchange of chromosomal proteins metal ion binding uc007yee.1 uc007yee.2 uc007yee.3 
ENSMUST00000051301.6 Pura ENSMUST00000051301.6 purine rich element binding protein A (from RefSeq NM_008989.4) ENSMUST00000051301.1 ENSMUST00000051301.2 ENSMUST00000051301.3 ENSMUST00000051301.4 ENSMUST00000051301.5 NM_008989 P42669 PURA_MOUSE uc008enh.1 uc008enh.2 uc008enh.3 uc008enh.4 uc008enh.5 uc008enh.6 This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the c-Myc gene. May play a role in the initiation of DNA replication and in recombination. Homodimer, heterodimer with PURB and heterotrimer with PURB and YBX1/Y-box protein 1 (PubMed:10318844). Interacts with FMR1; this interaction occurs in association with polyribosome (PubMed:12147688). Nucleus. Belongs to the PUR DNA-binding protein family. negative regulation of transcription from RNA polymerase II promoter translation repressor activity, nucleic acid binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding double-stranded telomeric DNA binding single-stranded DNA binding transcription factor activity, sequence-specific DNA binding RNA binding protein binding nucleus DNA replication factor A complex cytoplasm DNA unwinding involved in DNA replication apoptotic process mitotic cell cycle checkpoint nervous system development transcription factor binding cell proliferation positive regulation of cell proliferation postsynaptic density negative regulation of translation cell differentiation dendrite purine-rich negative regulatory element binding dendrite cytoplasm regulation of cell proliferation neuronal cell body sequence-specific DNA binding negative regulation of transcription, DNA-templated SMAD binding lymphocyte proliferation epithelial cell proliferation postsynapse dendritic transport of messenger ribonucleoprotein complex glutamatergic synapse uc008enh.1 uc008enh.2 uc008enh.3 uc008enh.4 uc008enh.5 uc008enh.6 
ENSMUST00000051310.13 Ddhd1 ENSMUST00000051310.13 DDHD domain containing 1, transcript variant 1 (from RefSeq NM_001039106.3) Ddhd1 ENSMUST00000051310.1 ENSMUST00000051310.10 ENSMUST00000051310.11 ENSMUST00000051310.12 ENSMUST00000051310.2 ENSMUST00000051310.3 ENSMUST00000051310.4 ENSMUST00000051310.5 ENSMUST00000051310.6 ENSMUST00000051310.7 ENSMUST00000051310.8 ENSMUST00000051310.9 F8WHP5 F8WHP5_MOUSE NM_001039106 uc007tgz.1 uc007tgz.2 uc007tgz.3 uc007tgz.4 Belongs to the PA-PLA1 family. metal ion binding uc007tgz.1 uc007tgz.2 uc007tgz.3 uc007tgz.4 
ENSMUST00000051312.5 Foxl2 ENSMUST00000051312.5 forkhead box L2 (from RefSeq NM_012020.3) ENSMUST00000051312.1 ENSMUST00000051312.2 ENSMUST00000051312.3 ENSMUST00000051312.4 Foxl2 NM_012020 Q2TVT7 Q2TVT7_MOUSE uc009rdr.1 uc009rdr.2 uc009rdr.3 uc009rdr.4 Nucleus ovarian follicle development oocyte growth extraocular skeletal muscle development DNA binding transcription factor activity, sequence-specific DNA binding nucleus apoptotic DNA fragmentation regulation of transcription, DNA-templated ubiquitin conjugating enzyme binding cysteine-type endopeptidase regulator activity involved in apoptotic process positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process sequence-specific DNA binding intercellular bridge negative regulation of transcription, DNA-templated embryonic eye morphogenesis uc009rdr.1 uc009rdr.2 uc009rdr.3 uc009rdr.4 
ENSMUST00000051341.6 Mfsd5 ENSMUST00000051341.6 major facilitator superfamily domain containing 5 (from RefSeq NM_134100.4) ENSMUST00000051341.1 ENSMUST00000051341.2 ENSMUST00000051341.3 ENSMUST00000051341.4 ENSMUST00000051341.5 MFSD5_MOUSE NM_134100 Q921Y4 uc007xve.1 uc007xve.2 uc007xve.3 Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. Cell membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. molecular_function plasma membrane ion transport biological_process molybdate ion transmembrane transporter activity molybdate ion transport membrane integral component of membrane uc007xve.1 uc007xve.2 uc007xve.3 
ENSMUST00000051355.7 Or52l1 ENSMUST00000051355.7 olfactory receptor family 52 subfamily L member 1 (from RefSeq NM_001011857.1) ENSMUST00000051355.1 ENSMUST00000051355.2 ENSMUST00000051355.3 ENSMUST00000051355.4 ENSMUST00000051355.5 ENSMUST00000051355.6 F7AKJ2 NM_001011857 Olfr685 Or52l1 Q7TRN7 Q7TRN7_MOUSE uc291txb.1 uc291txb.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291txb.1 uc291txb.2 
ENSMUST00000051358.11 Fbxl13 ENSMUST00000051358.11 F-box and leucine-rich repeat protein 13, transcript variant 2 (from RefSeq NM_177076.4) Drc6 ENSMUST00000051358.1 ENSMUST00000051358.10 ENSMUST00000051358.2 ENSMUST00000051358.3 ENSMUST00000051358.4 ENSMUST00000051358.5 ENSMUST00000051358.6 ENSMUST00000051358.7 ENSMUST00000051358.8 ENSMUST00000051358.9 FXL13_MOUSE NM_177076 Q8CDE9 Q8CDU4 uc008wop.1 uc008wop.2 uc008wop.3 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Component of the nexin- dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Specifically targets CEP192 isoform 3 for ubiquitin-mediated proteolysis and thereby acts as a regulator of microtubule nucleation activity. Component of the nexin-dynein regulatory complex (N-DRC). Directly interacts with SKP1 and CUL1 (By similarity). Interacts with TCTE1/DRC5 (PubMed:28630322). Cytoplasm, cytoskeleton, flagellum axoneme Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CDU4-1; Sequence=Displayed; Name=2; IsoId=Q8CDU4-2; Sequence=VSP_013006, VSP_013007, VSP_013008; Belongs to the DRC6 family. Sequence=BAC26515.1; Type=Frameshift; Evidence=; Sequence=BAC26821.1; Type=Frameshift; Evidence=; protein binding cytoplasm cytoskeleton cilium ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process motile cilium cell projection ubiquitin-protein transferase activity uc008wop.1 uc008wop.2 uc008wop.3 
ENSMUST00000051377.15 Dpy19l3 ENSMUST00000051377.15 dpy-19 like C-mannosyltransferase 3 (from RefSeq NM_178704.3) D19L3_MOUSE ENSMUST00000051377.1 ENSMUST00000051377.10 ENSMUST00000051377.11 ENSMUST00000051377.12 ENSMUST00000051377.13 ENSMUST00000051377.14 ENSMUST00000051377.2 ENSMUST00000051377.3 ENSMUST00000051377.4 ENSMUST00000051377.5 ENSMUST00000051377.6 ENSMUST00000051377.7 ENSMUST00000051377.8 ENSMUST00000051377.9 NM_178704 Q6PB46 Q71B07 Q80W29 Q8BLA9 Q8BZL3 Q8BZW5 uc009gkg.1 uc009gkg.2 uc009gkg.3 uc009gkg.4 Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Membrane ; Multi-pass membrane protein Belongs to the dpy-19 family. Sequence=AAH59897.1; Type=Frameshift; Evidence=; mannosyltransferase activity nuclear inner membrane membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan uc009gkg.1 uc009gkg.2 uc009gkg.3 uc009gkg.4 
ENSMUST00000051379.14 Mtus1 ENSMUST00000051379.14 mitochondrial tumor suppressor 1, transcript variant 11 (from RefSeq NM_001403955.1) A0A0R4J0N9 A0A0R4J0N9_MOUSE ENSMUST00000051379.1 ENSMUST00000051379.10 ENSMUST00000051379.11 ENSMUST00000051379.12 ENSMUST00000051379.13 ENSMUST00000051379.2 ENSMUST00000051379.3 ENSMUST00000051379.4 ENSMUST00000051379.5 ENSMUST00000051379.6 ENSMUST00000051379.7 ENSMUST00000051379.8 ENSMUST00000051379.9 Mtus1 NM_001403955 uc009lnk.1 uc009lnk.2 uc009lnk.3 uc009lnk.4 Nucleus Belongs to the MTUS1 family. uc009lnk.1 uc009lnk.2 uc009lnk.3 uc009lnk.4 
ENSMUST00000051386.13 Vill ENSMUST00000051386.13 villin-like, transcript variant 1 (from RefSeq NM_001164567.1) ENSMUST00000051386.1 ENSMUST00000051386.10 ENSMUST00000051386.11 ENSMUST00000051386.12 ENSMUST00000051386.2 ENSMUST00000051386.3 ENSMUST00000051386.4 ENSMUST00000051386.5 ENSMUST00000051386.6 ENSMUST00000051386.7 ENSMUST00000051386.8 ENSMUST00000051386.9 G5E8C6 G5E8C6_MOUSE NM_001164567 Vill uc009sac.1 uc009sac.2 uc009sac.3 uc009sac.4 Belongs to the villin/gelsolin family. actin binding cytoskeleton organization actin filament binding uc009sac.1 uc009sac.2 uc009sac.3 uc009sac.4 
ENSMUST00000051395.9 Prr11 ENSMUST00000051395.9 proline rich 11 (from RefSeq NM_175563.5) B2KGQ3 ENSMUST00000051395.1 ENSMUST00000051395.2 ENSMUST00000051395.3 ENSMUST00000051395.4 ENSMUST00000051395.5 ENSMUST00000051395.6 ENSMUST00000051395.7 ENSMUST00000051395.8 NM_175563 PRR11_MOUSE Q3V3H1 Q8BHE0 uc007kth.1 uc007kth.2 uc007kth.3 uc007kth.4 Plays a critical role in cell cycle progression. Cytoplasm Ubiquitinated. Rapidly degraded by the proteasome; degradation may involve FBXW7-specific phosphorylated phosphodegron motifs. molecular_function nucleus cytoplasm cell cycle arrest regulation of cell cycle uc007kth.1 uc007kth.2 uc007kth.3 uc007kth.4 
ENSMUST00000051400.8 Cyp4x1 ENSMUST00000051400.8 cytochrome P450, family 4, subfamily x, polypeptide 1 (from RefSeq NM_001003947.3) CP4X1_MOUSE Cyp4x1 ENSMUST00000051400.1 ENSMUST00000051400.2 ENSMUST00000051400.3 ENSMUST00000051400.4 ENSMUST00000051400.5 ENSMUST00000051400.6 ENSMUST00000051400.7 NM_001003947 Q2HJC6 Q6A152 Q8BYS0 uc008uep.1 uc008uep.2 A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Reaction=N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy- 5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53148, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:136991; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53149; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane ; Single-pass membrane protein Microsome membrane ; Single-pass membrane protein Expressed in brain and aorta. In the brain, expressed in the Purkinje cells of the cerebellum, pyramidal neurons in the dentate gyrus of the hippocampus, cortical forebrain neurons and those of brain stem nuclei (at protein level). In addition to neurons, also expressed in cerebral vascular endothelial cells (at protein level). Also expressed in epithelial cells of the choroid plexus (at protein level). Hardly detectable in heart, lung, kidney and spleen. Belongs to the cytochrome P450 family. molecular_function monooxygenase activity iron ion binding cellular_component endoplasmic reticulum endoplasmic reticulum membrane biological_process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding organelle membrane intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc008uep.1 uc008uep.2 
ENSMUST00000051401.4 Cldn4 ENSMUST00000051401.4 claudin 4 (from RefSeq NM_009903.2) Cldn4 ENSMUST00000051401.1 ENSMUST00000051401.2 ENSMUST00000051401.3 NM_009903 Q3UM35 Q3UM35_MOUSE uc008zxd.1 uc008zxd.2 uc008zxd.3 uc008zxd.4 uc008zxd.5 uc008zxd.6 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a high-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein augments alveolar epithelial barrier function and is induced in acute lung injury. It is highly expressed in pancreatic and ovarian cancers. [provided by RefSeq, Aug 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the claudin family. structural molecule activity plasma membrane bicellular tight junction female pregnancy circadian rhythm basal plasma membrane membrane integral component of membrane apical plasma membrane apicolateral plasma membrane lateral plasma membrane cell junction response to progesterone uc008zxd.1 uc008zxd.2 uc008zxd.3 uc008zxd.4 uc008zxd.5 uc008zxd.6 
ENSMUST00000051408.8 Clrn1 ENSMUST00000051408.8 clarin 1, transcript variant 2 (from RefSeq NM_153385.3) CLRN1_MOUSE ENSMUST00000051408.1 ENSMUST00000051408.2 ENSMUST00000051408.3 ENSMUST00000051408.4 ENSMUST00000051408.5 ENSMUST00000051408.6 ENSMUST00000051408.7 NM_153385 Q8K445 Q8K446 Ush3a uc008pie.1 uc008pie.2 uc008pie.3 uc008pie.4 May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K445-1; Sequence=Displayed; Name=2; IsoId=Q8K445-2; Sequence=VSP_022870; Belongs to the clarin family. plasma membrane microvillus actin filament organization visual perception sensory perception of sound positive regulation of lamellipodium assembly membrane integral component of membrane lamellipodium trans-Golgi network transport vesicle stereocilium basal part of cell photoreceptor cell maintenance cell motility neuromuscular process controlling balance response to stimulus sensory perception of light stimulus equilibrioception auditory receptor cell stereocilium organization auditory receptor cell development microtubule uc008pie.1 uc008pie.2 uc008pie.3 uc008pie.4 
ENSMUST00000051416.12 Hnmt ENSMUST00000051416.12 histamine N-methyltransferase (from RefSeq NM_080462.2) ENSMUST00000051416.1 ENSMUST00000051416.10 ENSMUST00000051416.11 ENSMUST00000051416.2 ENSMUST00000051416.3 ENSMUST00000051416.4 ENSMUST00000051416.5 ENSMUST00000051416.6 ENSMUST00000051416.7 ENSMUST00000051416.8 ENSMUST00000051416.9 HNMT_MOUSE Hmt NM_080462 Q3TVH0 Q91VF2 uc008iok.1 uc008iok.2 uc008iok.3 uc008iok.4 uc008iok.5 Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. Reaction=histamine + S-adenosyl-L-methionine = H(+) + N(tau)- methylhistamine + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:19301, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:58432, ChEBI:CHEBI:58600, ChEBI:CHEBI:59789; EC=2.1.1.8; Evidence= Kinetic parameters: KM=5.8 uM for S-adenosyl-L-methionine ; KM=5.3 uM for histamine ; Monomer. Cytoplasm Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family. regulation of neurotransmitter levels histamine catabolic process response to tumor cell cytoplasm hyperosmotic response brain development methyltransferase activity N-methyltransferase activity response to amine transferase activity methylation response to immobilization stress response to cocaine neuron projection histamine N-methyltransferase activity response to glucocorticoid response to interleukin-1 uc008iok.1 uc008iok.2 uc008iok.3 uc008iok.4 uc008iok.5 
ENSMUST00000051430.7 Marveld3 ENSMUST00000051430.7 MARVEL (membrane-associating) domain containing 3, transcript variant 1 (from RefSeq NM_028584.3) ENSMUST00000051430.1 ENSMUST00000051430.2 ENSMUST00000051430.3 ENSMUST00000051430.4 ENSMUST00000051430.5 ENSMUST00000051430.6 G3X9A4 G3X9A4_MOUSE Marveld3 NM_028584 uc009njq.1 uc009njq.2 uc009njq.3 uc009njq.4 Membrane ; Multi- pass membrane protein membrane integral component of membrane uc009njq.1 uc009njq.2 uc009njq.3 uc009njq.4 
ENSMUST00000051431.10 Fbxo28 ENSMUST00000051431.10 F-box protein 28 (from RefSeq NM_175127.2) D1Ertd578e ENSMUST00000051431.1 ENSMUST00000051431.2 ENSMUST00000051431.3 ENSMUST00000051431.4 ENSMUST00000051431.5 ENSMUST00000051431.6 ENSMUST00000051431.7 ENSMUST00000051431.8 ENSMUST00000051431.9 FBX28_MOUSE Kiaa0483 NM_175127 Q3TS97 Q7TMH9 Q8BIF6 Q8BIG4 uc007dyb.1 uc007dyb.2 uc007dyb.3 Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Chromosome, centromere, kinetochore Sequence=AAH55458.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; chromosome, centromeric region kinetochore condensed chromosome kinetochore molecular_function chromosome biological_process uc007dyb.1 uc007dyb.2 uc007dyb.3 
ENSMUST00000051435.8 Zfp418 ENSMUST00000051435.8 zinc finger protein 418 (from RefSeq NM_146179.2) ENSMUST00000051435.1 ENSMUST00000051435.2 ENSMUST00000051435.3 ENSMUST00000051435.4 ENSMUST00000051435.5 ENSMUST00000051435.6 ENSMUST00000051435.7 NM_146179 Q8BFS8 ZN418_MOUSE ZNF418 Zfp418 uc009fck.1 uc009fck.2 uc009fck.3 Transcriptional repressor (By similarity). May play a role as regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway (PubMed:33249983). Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009fck.1 uc009fck.2 uc009fck.3 
ENSMUST00000051442.7 Pcdhb16 ENSMUST00000051442.7 protocadherin beta 16 (from RefSeq NM_053141.3) ENSMUST00000051442.1 ENSMUST00000051442.2 ENSMUST00000051442.3 ENSMUST00000051442.4 ENSMUST00000051442.5 ENSMUST00000051442.6 NM_053141 Pcdhb16 Q91Y03 Q91Y03_MOUSE uc008eqb.1 uc008eqb.2 uc008eqb.3 uc008eqb.4 calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules chemical synaptic transmission synapse assembly membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules photoreceptor connecting cilium synapse postsynaptic membrane photoreceptor disc membrane uc008eqb.1 uc008eqb.2 uc008eqb.3 uc008eqb.4 
ENSMUST00000051453.2 Or4k2 ENSMUST00000051453.2 olfactory receptor family 4 subfamily K member 2 (from RefSeq NM_146493.2) E9Q8M3 E9Q8M3_MOUSE ENSMUST00000051453.1 NM_146493 Olfr730 Or4k2 uc007tkt.1 uc007tkt.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007tkt.1 uc007tkt.2 
ENSMUST00000051454.4 Fam171b ENSMUST00000051454.4 family with sequence similarity 171, member B (from RefSeq NM_175514.3) ENSMUST00000051454.1 ENSMUST00000051454.2 ENSMUST00000051454.3 F171B_MOUSE NM_175514 Q14CH0 Q8C756 Q8CAF3 Q8CBZ4 Q8CFT5 uc008kie.1 uc008kie.2 uc008kie.3 Cytoplasmic granule Membrane ; Single-pass type I membrane protein Note=In neurons, localizes to vesicular-like puncta in the cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14CH0-1; Sequence=Displayed; Name=2; IsoId=Q14CH0-2; Sequence=VSP_025343; Expressed in the brain, predominantly in the thalamus, in the hippocampal formation (in CA1, CA2 and CA3 regions and in the dentate gyrus), in the cerebellum (in Purkinje and granule cell layers, as well as neurons of the deep cerebellar nuclei) and cerebral cortex (at protein level) (PubMed:34052262). Expressed predominantly in neurons (PubMed:34052262). Belongs to the FAM171 family. Sequence=BAC28648.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008kie.1 uc008kie.2 uc008kie.3 
ENSMUST00000051477.13 Cdc42 ENSMUST00000051477.13 cell division cycle 42, transcript variant 16 (from RefSeq NR_185141.1) A2A9U6 CDC42_MOUSE Cdc42 ENSMUST00000051477.1 ENSMUST00000051477.10 ENSMUST00000051477.11 ENSMUST00000051477.12 ENSMUST00000051477.2 ENSMUST00000051477.3 ENSMUST00000051477.4 ENSMUST00000051477.5 ENSMUST00000051477.6 ENSMUST00000051477.7 ENSMUST00000051477.8 ENSMUST00000051477.9 NR_185141 P21181 P25763 P60766 Q3THZ7 Q3TJK6 Q545V0 Q6P201 Q8BQ51 uc008viw.1 uc008viw.2 uc008viw.3 uc008viw.4 uc008viw.5 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:24352656). In its active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration (By similarity). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons (PubMed:25851601). Facilitates filopodia formation upon DOCK11-activation (PubMed:22494997). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Inhibited by GAPs such as ARHGAP44 (PubMed:24352656, PubMed:26969129). Interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP- dependent manner) (PubMed:10490598, PubMed:10934474). Interacts with activated CSPG4 and with BAIAP2 (By similarity). Interacts with DOCK11/Zizimin2; the interaction activates CDC42 by exchanging GDP for GTP (PubMed:15710388, PubMed:16968698). Interacts with DOCK9; the interaction activates CDC42 by exchanging GDP for GTP (By similarity). Interacts with DOCK8 (via DHR-2 domain); the interaction activates CDC42 by exchanging GDP for GTP (PubMed:22461490). Interacts with IQGAP1 (PubMed:16968698). Interacts with NET1 and ARHGAP33/TCGAP (PubMed:9535835, PubMed:12773384). Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ (PubMed:10934474). The GTP-bound form interacts with CCPG1 (PubMed:17000758). Interacts with USP6 (By similarity). Interacts with NEK6 (By similarity). Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas (By similarity). Interacts with ITGB1BP1 (By similarity). Interacts with ARHGDIA; this interaction inactivates and stabilizes CDC42. Interacts with ARHGDIB; this maintains CDC42 in the inactive, GDP-bound form (By similarity). Interacts in (GTP-bound form) with FNBP1L and ABI1, but only in the presence of FNBP1L (By similarity). P60766; O88643: Pak1; NbExp=2; IntAct=EBI-81763, EBI-457240; P60766; P63044: Vamp2; NbExp=2; IntAct=EBI-81763, EBI-521920; P60766; Q13153: PAK1; Xeno; NbExp=3; IntAct=EBI-81763, EBI-1307; Cell membrane ; Lipid-anchor ; Cytoplasmic side Midbody Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, dendrite Note=Localizes to spindle during prometaphase cells (By similarity). Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells (By similarity). Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome (By similarity). In its active GTP-bound form localizes to the leading edge membrane of migrating dendritic cells (PubMed:22461490). Event=Alternative splicing; Named isoforms=2; Name=2; Synonyms=Placental; IsoId=P60766-2, P21181-4; Sequence=Displayed; Name=1; Synonyms=Brain; IsoId=P60766-1, P21181-1; Sequence=VSP_040585, VSP_040586; Phosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation inhibitor RhoGDI. Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. Golgi membrane nucleotide binding storage vacuole sprouting angiogenesis cardiac conduction system development GTPase activity protein binding GTP binding cytoplasm microtubule organizing center spindle cytosol cytoskeleton plasma membrane cell-cell junction cell cortex endocytosis phagocytosis, engulfment actin filament organization Golgi organization regulation of mitotic nuclear division nuclear migration establishment or maintenance of cell polarity small GTPase mediated signal transduction Rho protein signal transduction nervous system development regulation of cell shape membrane endosomal transport hydrolase activity protein kinase binding cell projection assembly actin cytoskeleton organization secretory granule cell differentiation dendrite midbody GTP-dependent protein binding leading edge membrane lamellipodium membrane mitogen-activated protein kinase kinase kinase binding positive regulation of cytokinesis Cdc42 protein signal transduction regulation of actin cytoskeleton organization cell junction assembly adherens junction organization cellular protein localization establishment or maintenance of apical/basal cell polarity dendritic cell migration cell projection neuron projection positive regulation of catalytic activity dendritic spine myelin sheath regulation of protein binding positive regulation of MAPK cascade positive regulation of neuron apoptotic process positive regulation of phosphatidylinositol 3-kinase activity apical part of cell establishment of epithelial cell apical/basal polarity phagocytic vesicle positive regulation of DNA replication positive regulation of JNK cascade filopodium assembly neuron fate determination spindle midzone regulation of filopodium assembly positive regulation of filopodium assembly nucleus localization establishment of Golgi localization positive regulation of synapse structural plasticity regulation of attachment of spindle microtubules to kinetochore heart contraction positive regulation of epithelial cell proliferation involved in lung morphogenesis submandibular salivary gland formation dendritic spine morphogenesis cellular response to interferon-gamma cell periphery organelle transport along microtubule mitotic spindle actin filament branching positive regulation of intracellular protein transport cell-cell adhesion modification of synaptic structure positive regulation of substrate adhesion-dependent cell spreading uc008viw.1 uc008viw.2 uc008viw.3 uc008viw.4 uc008viw.5 
ENSMUST00000051482.2 Kcng3 ENSMUST00000051482.2 potassium voltage-gated channel, subfamily G, member 3 (from RefSeq NM_153512.1) ENSMUST00000051482.1 KCNG3_MOUSE NM_153512 P59053 uc008dsd.1 uc008dsd.2 Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Heterotetramer with KCNB1. Does not form homomultimers. Cell membrane ; Multi-pass membrane protein Cytoplasm Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Colocalizes with KCNB1 at the plasma membrane. Remains intracellular in the absence of KCNB1. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Kv10.1b; IsoId=P59053-1; Sequence=Displayed; Name=2; Synonyms=Kv10.1a; IsoId=P59053-2; Sequence=VSP_001027; The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity cytoplasm endoplasmic reticulum plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane regulation of ion transmembrane transport protein homooligomerization transmembrane transport potassium ion transmembrane transport uc008dsd.1 uc008dsd.2 
ENSMUST00000051484.5 Mageh1 ENSMUST00000051484.5 MAGE family member H1 (from RefSeq NM_023788.3) ENSMUST00000051484.1 ENSMUST00000051484.2 ENSMUST00000051484.3 ENSMUST00000051484.4 MAGH1_MOUSE NM_023788 Q99PB0 Q9NWG9 uc009uqq.1 uc009uqq.2 uc009uqq.3 molecular_function cytoplasm biological_process uc009uqq.1 uc009uqq.2 uc009uqq.3 
ENSMUST00000051490.15 Idnk ENSMUST00000051490.15 idnK gluconokinase homolog (E. coli), transcript variant 1 (from RefSeq NM_198004.3) ENSMUST00000051490.1 ENSMUST00000051490.10 ENSMUST00000051490.11 ENSMUST00000051490.12 ENSMUST00000051490.13 ENSMUST00000051490.14 ENSMUST00000051490.2 ENSMUST00000051490.3 ENSMUST00000051490.4 ENSMUST00000051490.5 ENSMUST00000051490.6 ENSMUST00000051490.7 ENSMUST00000051490.8 ENSMUST00000051490.9 GNTK_MOUSE NM_198004 Q8R0J8 uc007qth.1 uc007qth.2 uc007qth.3 uc007qth.4 Reaction=ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+); Xref=Rhea:RHEA:19433, ChEBI:CHEBI:15378, ChEBI:CHEBI:18391, ChEBI:CHEBI:30616, ChEBI:CHEBI:58759, ChEBI:CHEBI:456216; EC=2.7.1.12; Carbohydrate acid metabolism; D-gluconate degradation. Belongs to the gluconokinase GntK/GntV family. Sequence=AAH26742.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding ATP binding carbohydrate metabolic process kinase activity phosphorylation transferase activity D-gluconate catabolic process gluconokinase activity uc007qth.1 uc007qth.2 uc007qth.3 uc007qth.4 
ENSMUST00000051495.7 Pmis2 ENSMUST00000051495.7 PMIS2 transmembrane protein, transcript variant 1 (from RefSeq NR_027848.1) ENSMUST00000051495.1 ENSMUST00000051495.2 ENSMUST00000051495.3 ENSMUST00000051495.4 ENSMUST00000051495.5 ENSMUST00000051495.6 NR_027848 PMIS2_MOUSE Pmis2 Q497Q9 Q8CES1 uc009gfu.1 uc009gfu.2 uc009gfu.3 uc009gfu.4 uc009gfu.5 uc009gfu.6 uc009gfu.7 May play a role in spermatozoa mobility. Membrane ; Multi-pass membrane protein Specifically expressed in testis. Mice lacking Pmis2 are viable but display male infertility despite a normal mating behavior. The ability of spermatozoa to migrate through the uterotubal junction is impaired. Their binding to the zona pelucida of eggs is also altered. Belongs to the CD225/Dispanin family. molecular_function cellular_component single fertilization binding of sperm to zona pellucida membrane integral component of membrane uc009gfu.1 uc009gfu.2 uc009gfu.3 uc009gfu.4 uc009gfu.5 uc009gfu.6 uc009gfu.7 
ENSMUST00000051504.8 Ecm2 ENSMUST00000051504.8 extracellular matrix protein 2, female organ and adipocyte specific (from RefSeq NM_001012324.4) ECM2_MOUSE ENSMUST00000051504.1 ENSMUST00000051504.2 ENSMUST00000051504.3 ENSMUST00000051504.4 ENSMUST00000051504.5 ENSMUST00000051504.6 ENSMUST00000051504.7 NM_001012324 Q5FW85 uc007qjl.1 uc007qjl.2 Promotes matrix assembly and cell adhesiveness. Interacts with numerous extracellular matrix proteins (PubMed:18757743). Interacts with isoform 1 of MSL1 (PubMed:17335777). Interacts with isoform 3 of RASSF1 (PubMed:17335777). Secreted, extracellular space, extracellular matrix At 16.5 dpc, present in periosteum of ribs. At P0, present in tendons connecting the scapula and humerus to muscles (at protein level). Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. protein binding collagen binding extracellular region interstitial matrix heparin binding positive regulation of cell-substrate adhesion extracellular matrix organization extracellular matrix collagen V binding uc007qjl.1 uc007qjl.2 
ENSMUST00000051509.15 Ttll10 ENSMUST00000051509.15 tubulin tyrosine ligase-like family, member 10, transcript variant 1 (from RefSeq NM_029264.2) B1ASM0 B1ASM0_MOUSE ENSMUST00000051509.1 ENSMUST00000051509.10 ENSMUST00000051509.11 ENSMUST00000051509.12 ENSMUST00000051509.13 ENSMUST00000051509.14 ENSMUST00000051509.2 ENSMUST00000051509.3 ENSMUST00000051509.4 ENSMUST00000051509.5 ENSMUST00000051509.6 ENSMUST00000051509.7 ENSMUST00000051509.8 ENSMUST00000051509.9 NM_029264 Ttll10 uc008wga.1 uc008wga.2 uc008wga.3 cellular protein modification process uc008wga.1 uc008wga.2 uc008wga.3 
ENSMUST00000051521.5 Lce1h ENSMUST00000051521.5 late cornified envelope 1H (from RefSeq NM_026335.2) ENSMUST00000051521.1 ENSMUST00000051521.2 ENSMUST00000051521.3 ENSMUST00000051521.4 Lce1h NM_026335 Q9D6R3 Q9D6R3_MOUSE Sprrl9 uc008qeq.1 uc008qeq.2 Belongs to the LCE family. epidermis development uc008qeq.1 uc008qeq.2 
ENSMUST00000051532.5 Taar1 ENSMUST00000051532.5 trace amine-associated receptor 1 (from RefSeq NM_053205.1) ENSMUST00000051532.1 ENSMUST00000051532.2 ENSMUST00000051532.3 ENSMUST00000051532.4 NM_053205 Q05A85 Q923Y8 TAAR1_MOUSE Ta1 Tar1 Trar1 uc007eqd.1 uc007eqd.2 uc007eqd.3 Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase. Cell membrane; Multi-pass membrane protein. Widely distributed throughout the brain. Strongly expressed in the mitral cell layer of the olfactory bulb, piriform cortex, the arcuate, motor, and mesencephalic trigeminal nuclei, lateral reticular and hypoglossal nuclei, cerebellar Purkinje cells, and ventral horn of the spinal cord. Moderately expressed in the frontal, entorhinal, and agranular cortices, the ventral pallidum, thalamus, hippocampus, several hypothalamic nuclei, ambiguus, dorsal raphe, and gigantocellular reticular nuclei. Weakly expressed in the septum, basal ganglia, amygdala, myelencephalon, and spinal cord dorsal horn. Particularly interesting is the moderate expression in several monoaminergic cell groups, namely the dorsal raphe, the locus coeruleus, and the ventral tegmental area. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway G-protein coupled amine receptor activity membrane integral component of membrane positive regulation of cAMP-mediated signaling uc007eqd.1 uc007eqd.2 uc007eqd.3 
ENSMUST00000051552.11 Slc5a10 ENSMUST00000051552.11 solute carrier family 5 (sodium/glucose cotransporter), member 10, transcript variant 1 (from RefSeq NM_001033227.2) B9EJ50 ENSMUST00000051552.1 ENSMUST00000051552.10 ENSMUST00000051552.2 ENSMUST00000051552.3 ENSMUST00000051552.4 ENSMUST00000051552.5 ENSMUST00000051552.6 ENSMUST00000051552.7 ENSMUST00000051552.8 ENSMUST00000051552.9 NM_001033227 Q5SWY8 SC5AA_MOUSE Sglt5 uc007jib.1 uc007jib.2 Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2 (PubMed:23451068) (By similarity). Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney (PubMed:23451068) (By similarity). Reaction=D-mannose(out) + Na(+)(out) = D-mannose(in) + Na(+)(in); Xref=Rhea:RHEA:72907, ChEBI:CHEBI:4208, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72908; Evidence=; Reaction=D-fructopyranose(out) + Na(+)(out) = D-fructopyranose(in) + Na(+)(in); Xref=Rhea:RHEA:72915, ChEBI:CHEBI:29101, ChEBI:CHEBI:37714; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72916; Evidence=; Apical cell membrane ; Multi-pass membrane protein Predominantly expressed at high levels in kidney. Very low expression is detected in testes. Mice are born at the expected Mendelian rate and have no apparent morphological abnormalities. In response to long-term fructose consumption, they develop exacerbated hepatic steatosis associated with massive urinary fructose excretion and increased hepatic triglyceride levels. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. glucose:sodium symporter activity plasma membrane ion transport sodium ion transport membrane integral component of membrane transmembrane transporter activity transmembrane transport glucose transmembrane transport uc007jib.1 uc007jib.2 
ENSMUST00000051558.10 Chd7 ENSMUST00000051558.10 chromodomain helicase DNA binding protein 7, transcript variant 2 (from RefSeq NM_001355382.1) A2AJK6 CHD7_MOUSE ENSMUST00000051558.1 ENSMUST00000051558.2 ENSMUST00000051558.3 ENSMUST00000051558.4 ENSMUST00000051558.5 ENSMUST00000051558.6 ENSMUST00000051558.7 ENSMUST00000051558.8 ENSMUST00000051558.9 NM_001355382 Q3TA86 Q3TAG7 Q3TBU4 Q8C986 Q8K244 uc008ryb.1 uc008ryb.2 uc008ryb.3 This gene encodes a protein containing two chromodomains and an ATP-binding helicase domain that functions as a regulator of transcription. Mutations in this gene result in an array of development defects, including inner ear problems. Mice defective for this gene exhibit many of the clinical features of the CHARGE syndrome caused by mutations in the homologous gene in human. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.14855.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; May interact with CTCF (By similarity). Interacts with CHD8 (By similarity). Interacts with FAM124B. Found in a complex composed of AGO2, CHD7 and ARB2A (PubMed:29311329). Interacts with TLK2 (By similarity). A2AJK6; Q60I23: Sox2; NbExp=6; IntAct=EBI-6122905, EBI-6120118; Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AJK6-1; Sequence=Displayed; Name=2; IsoId=A2AJK6-2; Sequence=VSP_026040, VSP_026041; Name=3; IsoId=A2AJK6-3; Sequence=VSP_026042; Expressed in the outflow tract of the heart, optic vesicle, facio-acoustic preganglion complex, brain, olfactory pit, and mandibular component of the first branchial arch. [Isoform 2]: May be due to an intron retention. Belongs to the SNF2/RAD54 helicase family. Sequence=BAE42701.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE42701.1; Type=Frameshift; Evidence=; nucleotide binding RNA polymerase II core promoter proximal region sequence-specific DNA binding skeletal system development blood vessel development in utero embryonic development blood vessel remodeling heart morphogenesis ventricular trabecula myocardium morphogenesis right ventricular compact myocardium morphogenesis DNA binding DNA helicase activity helicase activity protein binding ATP binding nucleus nucleoplasm nucleolus chromatin organization chromatin remodeling rRNA processing central nervous system development adult heart development sensory perception of sound locomotory behavior adult walking behavior blood circulation response to bacterium regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum hydrolase activity hydrolase activity, acting on acid anhydrides cranial nerve development olfactory nerve development olfactory bulb development T cell differentiation female genitalia development DNA duplex unwinding embryonic hindlimb morphogenesis aorta development aorta morphogenesis atrioventricular canal development positive regulation of multicellular organism growth olfactory behavior ear morphogenesis inner ear morphogenesis camera-type eye development nose development positive regulation of transcription from RNA polymerase II promoter semicircular canal morphogenesis tissue remodeling genitalia development artery morphogenesis regulation of neurogenesis cognition palate development retina development in camera-type eye regulation of growth hormone secretion limb development face development innervation cardiac septum morphogenesis epithelium development promoter-specific chromatin binding uc008ryb.1 uc008ryb.2 uc008ryb.3 
ENSMUST00000051572.8 Cavin2 ENSMUST00000051572.8 caveolae associated 2 (from RefSeq NM_138741.1) CAVN2_MOUSE ENSMUST00000051572.1 ENSMUST00000051572.2 ENSMUST00000051572.3 ENSMUST00000051572.4 ENSMUST00000051572.5 ENSMUST00000051572.6 ENSMUST00000051572.7 NM_138741 Q3V1P6 Q63918 Q78EC3 Q8CBT4 Sdpr Sdr uc007axk.1 uc007axk.2 Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (By similarity). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells (PubMed:23652019). May play a role in targeting PRKCA to caveolae (By similarity). Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4 (PubMed:19546242). Binds to PRKCA in the presence of phosphatidylserine. Interacts with CAVIN4; this augments the transactivation of NPPA by CAVIN4 (By similarity). Interacts with CAVIN1 (PubMed:25588833, PubMed:19546242). Interacts with CAV3 (By similarity). Cytoplasm, cytosol mbrane, caveola Note=Localizes in the caveolae in a caveolin-dependent manner. Heart, adipose tissue, lung and endothelial cells (at protein level). Highly expressed in kidney and expressed at lower levels in liver, spleen, thymus, stomach, intestine and uterus. Expression gradually increases during embryonic stages and reaches a maximum in neonates. Up-regulated in response to cardiac hypertrophy and in serum-starved but not in density-dependent growth-arrested NIH3T3 cells. Down-regulated within 6 hours after the addition of serum or epidermal growth factor to serum-starved cells. The leucine-zipper domain is essential for its localization in the caveolae. The N-terminus is blocked. Mice show loss of endothelial caveolae in lung and adipose tissue but no effect on the abundance of endothelial caveolae in the heart. Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine (By similarity). Belongs to the CAVIN family. phosphatidylserine binding protein kinase C binding protein binding nucleoplasm cytoplasm cytosol plasma membrane caveola lipid binding actin cytoskeleton membrane membrane raft positive regulation of transcription from RNA polymerase II promoter plasma membrane tubulation uc007axk.1 uc007axk.2 
ENSMUST00000051589.9 Aasdhppt ENSMUST00000051589.9 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase, transcript variant 1 (from RefSeq NM_026276.3) ADPPT_MOUSE ENSMUST00000051589.1 ENSMUST00000051589.2 ENSMUST00000051589.3 ENSMUST00000051589.4 ENSMUST00000051589.5 ENSMUST00000051589.6 ENSMUST00000051589.7 ENSMUST00000051589.8 NM_026276 Q5U5W8 Q9CQF6 Q9CU40 Q9D827 uc009obe.1 uc009obe.2 uc009obe.3 uc009obe.4 Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN. Reaction=apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo- [ACP]; Xref=Rhea:RHEA:12068, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:9690, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:58343, ChEBI:CHEBI:64479; EC=2.7.8.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12069; Evidence=; Reaction=acetyl-CoA + apo-[ACP] = acetyl-[ACP] + adenosine 3',5'- bisphosphate + H(+); Xref=Rhea:RHEA:46564, Rhea:RHEA-COMP:9621, Rhea:RHEA-COMP:9690, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57288, ChEBI:CHEBI:58343, ChEBI:CHEBI:78446; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46565; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion. ; Monomer. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQF6-1; Sequence=Displayed; Name=2; IsoId=Q9CQF6-2; Sequence=VSP_016096; Belongs to the P-Pant transferase superfamily. AcpS family. magnesium ion binding cytoplasm holo-[acyl-carrier-protein] synthase activity transferase activity lysine biosynthetic process via aminoadipic acid metal ion binding uc009obe.1 uc009obe.2 uc009obe.3 uc009obe.4 
ENSMUST00000051594.12 Depdc1b ENSMUST00000051594.12 DEP domain containing 1B, transcript variant 1 (from RefSeq NM_178683.5) DEP1B_MOUSE ENSMUST00000051594.1 ENSMUST00000051594.10 ENSMUST00000051594.11 ENSMUST00000051594.2 ENSMUST00000051594.3 ENSMUST00000051594.4 ENSMUST00000051594.5 ENSMUST00000051594.6 ENSMUST00000051594.7 ENSMUST00000051594.8 ENSMUST00000051594.9 NM_178683 Q810T1 Q8BH88 Q8BZ67 uc007rvc.1 uc007rvc.2 uc007rvc.3 molecular_function GTPase activator activity signal transduction cell migration positive regulation of Wnt signaling pathway intracellular signal transduction positive regulation of GTPase activity uc007rvc.1 uc007rvc.2 uc007rvc.3 
ENSMUST00000051605.9 Dut ENSMUST00000051605.9 deoxyuridine triphosphatase, transcript variant 2 (from RefSeq NM_023595.6) DUT_MOUSE Dutp ENSMUST00000051605.1 ENSMUST00000051605.2 ENSMUST00000051605.3 ENSMUST00000051605.4 ENSMUST00000051605.5 ENSMUST00000051605.6 ENSMUST00000051605.7 ENSMUST00000051605.8 NM_023595 Q8VCG1 Q9CQ43 Q9JJ44 uc008mcl.1 uc008mcl.2 uc008mcl.3 uc008mcl.4 Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (By similarity). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (PubMed:30987342). Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=3.6.1.23; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. Homotrimer. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQ43-1; Sequence=Displayed; Name=2; IsoId=Q9CQ43-2; Sequence=VSP_061339; Phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Embryos reach the blastocyst stage, however, they die shortly after implantation and analysis of pre-implantation embryos indicates perturbed growth of both inner cell mass and trophectoderm. Belongs to the dUTPase family. magnesium ion binding dUTP diphosphatase activity nucleus nucleoplasm cytoplasm mitochondrion cytosol dUMP biosynthetic process receptor inhibitor activity pyrimidine deoxyribonucleotide binding peroxisome proliferator activated receptor binding regulation of protein heterodimerization activity dUTP catabolic process protein homotrimerization negative regulation of receptor activity uc008mcl.1 uc008mcl.2 uc008mcl.3 uc008mcl.4 
ENSMUST00000051614.5 Adam24 ENSMUST00000051614.5 ADAM metallopeptidase domain 24 (from RefSeq NM_010086.5) A6H683 ADA24_MOUSE Adam24 E9QL68 ENSMUST00000051614.1 ENSMUST00000051614.2 ENSMUST00000051614.3 ENSMUST00000051614.4 NM_010086 Q9R160 uc009lnb.1 uc009lnb.2 uc009lnb.3 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. Male mice lacking the encoded protein exhibit reduced fertility due to the higher incidence of polyspermic embryos. This gene is located adjacent to other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]. ##Evidence-Data-START## Transcript exon combination :: AK029528.1, BB614583.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Monomer. Membrane ; Single- pass type I membrane protein Note=Localized to the equatorial region of the plasma membrane of cauda epididymal sperm. Expressed exclusively in testis and more specifically on the surface of mature sperm (at protein level). Adult expression levels are reached by day 20 after birth. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The prodomain is removed during sperm passage through the caput epididymis after the protein has reached the cell surface. Not processed in the secretory pathway. metalloendopeptidase activity integrin binding proteolysis multicellular organism development spermatogenesis peptidase activity metallopeptidase activity external side of plasma membrane membrane integral component of membrane hydrolase activity cell differentiation metal ion binding prevention of polyspermy sperm head plasma membrane uc009lnb.1 uc009lnb.2 uc009lnb.3 
ENSMUST00000051620.5 Cyb5d1 ENSMUST00000051620.5 cytochrome b5 domain containing 1 (from RefSeq NM_001045525.2) CB5D1_MOUSE ENSMUST00000051620.1 ENSMUST00000051620.2 ENSMUST00000051620.3 ENSMUST00000051620.4 Gm740 NM_001045525 Q5NCY3 Q5NCY4 uc007jpz.1 uc007jpz.2 uc007jpz.3 uc007jpz.4 Radial spoke stalk protein that binds heme under oxidizing conditions. Required for the coordinated beating of multiple cilia maybe by functioning in a redox signaling pathway. Cytoplasm, cytoskeleton, cilium axoneme Note=Localizes to the radial spoke stalk. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5NCY3-1; Sequence=Displayed; Name=2; IsoId=Q5NCY3-2; Sequence=VSP_029825, VSP_029826; Belongs to the cytochrome b5 family. molecular_function cellular_component biological_process metal ion binding uc007jpz.1 uc007jpz.2 uc007jpz.3 uc007jpz.4 
ENSMUST00000051633.3 Ubiad1 ENSMUST00000051633.3 UbiA prenyltransferase domain containing 1 (from RefSeq NM_027873.3) A2AH70 B2KFZ5 ENSMUST00000051633.1 ENSMUST00000051633.2 NM_027873 Q6IR30 Q8BJX7 Q9DC60 UBIA1_MOUSE uc008vup.1 uc008vup.2 uc008vup.3 Prenyltransferase that mediates the formation of menaquinone- 4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress. Reaction=(2E,6E,10E)-geranylgeranyl diphosphate + menadiol = diphosphate + menaquinol-4; Xref=Rhea:RHEA:74083, ChEBI:CHEBI:6746, ChEBI:CHEBI:33019, ChEBI:CHEBI:58756, ChEBI:CHEBI:193091; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74084; Evidence=; Reaction=4-hydroxybenzoate + all-trans-decaprenyl diphosphate = 4- hydroxy-3-all-trans-decaprenylbenzoate + diphosphate; Xref=Rhea:RHEA:44564, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:60721, ChEBI:CHEBI:84503; EC=2.5.1.39; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44565; Evidence=; Quinol/quinone metabolism; menaquinone biosynthesis. Cofactor biosynthesis; ubiquinone biosynthesis. Interacts with HMGCR and SOAT1. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Belongs to the UbiA prenyltransferase family. Golgi membrane endothelial cell development prenyltransferase activity nucleus cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus ubiquinone biosynthetic process menaquinone biosynthetic process membrane integral component of membrane antioxidant activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups integral component of Golgi membrane ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate vitamin K biosynthetic process cardiovascular system development cellular oxidant detoxification uc008vup.1 uc008vup.2 uc008vup.3 
ENSMUST00000051667.14 Zfp105 ENSMUST00000051667.14 zinc finger protein 105 (from RefSeq NM_009544.2) ENSMUST00000051667.1 ENSMUST00000051667.10 ENSMUST00000051667.11 ENSMUST00000051667.12 ENSMUST00000051667.13 ENSMUST00000051667.2 ENSMUST00000051667.3 ENSMUST00000051667.4 ENSMUST00000051667.5 ENSMUST00000051667.6 ENSMUST00000051667.7 ENSMUST00000051667.8 ENSMUST00000051667.9 G3X9I0 G3X9I0_MOUSE NM_009544 Zfp105 uc009sfi.1 uc009sfi.2 uc009sfi.3 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding perinuclear region of cytoplasm uc009sfi.1 uc009sfi.2 uc009sfi.3 
ENSMUST00000051672.9 Bst2 ENSMUST00000051672.9 bone marrow stromal cell antigen 2 (from RefSeq NM_198095.3) BST2_MOUSE ENSMUST00000051672.1 ENSMUST00000051672.2 ENSMUST00000051672.3 ENSMUST00000051672.4 ENSMUST00000051672.5 ENSMUST00000051672.6 ENSMUST00000051672.7 ENSMUST00000051672.8 NM_198095 Q8CEY7 Q8R2Q8 uc009mdr.1 uc009mdr.2 uc009mdr.3 uc009mdr.4 IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Parallel homodimer; disulfide-linked. May form homotetramers under reducing conditions. Dimerization is essential for its antiviral activity. Interacts (via cytoplasmic domain) with ARHGAP44 (By similarity). Interacts with MMP14 (via C-terminal cytoplasmic tail) (By similarity). Interacts with LILRA4/ILT7 (By similarity). Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane ; Lipid-anchor, GPI-anchor Late endosome Membrane raft Cytoplasm Apical cell membrane Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. Forms a complex with MMP14 and localizes to the cytoplasm (By similarity). In naive mice, specifically expressed on type I interferon-producing cells (at protein level). By viral or other interferon-inducing stimulation in most cell types (at protein level). Down-regulated by ebola virus GP protein. The extracellular coiled coil domain forms an extended 170 A long semi-flexible rod-like structure important for virion retention at the cell surface and prevention of virus spreading. immune system process negative regulation of plasmacytoid dendritic cell cytokine production cytoplasm endosome late endosome Golgi apparatus plasma membrane metalloendopeptidase inhibitor activity response to virus cell surface negative regulation of endopeptidase activity membrane integral component of membrane apical plasma membrane negative regulation of cell growth negative regulation of cell migration anchored component of membrane regulation of actin cytoskeleton organization response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication innate immune response membrane raft defense response to virus negative regulation of intracellular transport of viral material uc009mdr.1 uc009mdr.2 uc009mdr.3 uc009mdr.4 
ENSMUST00000051674.3 Lin28a ENSMUST00000051674.3 lin-28 homolog A (from RefSeq NM_145833.1) ENSMUST00000051674.1 ENSMUST00000051674.2 LN28A_MOUSE Lin28 NM_145833 Q6NV62 Q8K3Y3 Tex17 uc008vdw.1 uc008vdw.2 uc008vdw.3 RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:17473174, PubMed:18604195, PubMed:18566191, PubMed:18292307, PubMed:19703396, PubMed:23102813, PubMed:24209617). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (PubMed:26045559). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (PubMed:17473174). Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 and TUT7 uridylyltransferaseS. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7- mediated differentiation of embryonic stem cells (PubMed:19703396, PubMed:28671666). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins (PubMed:23102813). Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (PubMed:24209617). Monomer (PubMed:22078496). During skeletal muscle differentiation, associated with translation initiation complexes in the polysomal compartment (By similarity). Directly interacts with EIF3S2 (PubMed:17473174). Interacts with NCL in an RNA-dependent manner (By similarity). Interacts with TUT4 in the presence of pre-let-7 RNA (PubMed:28671666). Q8K3Y3; Q8CI75: Dis3l2; NbExp=2; IntAct=EBI-11109197, EBI-16045218; Cytoplasm ugh endoplasmic reticulum Cytoplasm, P-body Cytoplasm, Stress granule Nucleus, nucleolus Note=Predominantly cytoplasmic (PubMed:12798299). In the cytoplasm, localizes to peri-endoplasmic reticulum regions and detected in the microsomal fraction derived from rough endoplasmic reticulum (RER) following subcellular fractionation. May be bound to the cytosolic surface of RER on which ER-associated mRNAs are translated (PubMed:23102813). Shuttle from the nucleus to the cytoplasm requires RNA-binding (PubMed:17473174). Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (PubMed:17473174). Expressed in embryonic stem cells (ES cells), spermatagonia and testis. Expressed in numerous epithelial tissues including the epithelia of the small intestine, the intralobular duct epithelium of the mammary gland and the epithelia of Henle's loop in the kidney and in the collecting duct (at protein level). Also expressed in the myocardium and skeletal muscle (at protein level). Strongly expressed throughout the whole embryo at 6.5 dpc, including the embryonic and extraembryonic ectoderm and endoderm (at protein level). Subsequently expressed in the ectoderm, endoderm and mesoderm at 7.5 dpc (at protein level). At 9.5 dpc, expressed in epithelia covering the first branchial arch and the coelomic cavity, the myocardium of the developing heart, the neuroepithelium and some extraembryonic tissues such as the visceral yolk sac (at protein level). Expression persists in a variety of epithelial tissues at 10.5 dpc. At 15.5 dpc, expression is lost in bronchial epithelium and becomes weaker in neuroepithelium, while increasing in the myotome of somites, the foregut epithelium, stratified epithelium and some kidney tubules (at protein level). At 17.5 dpc, expression persists in the myocardium and in the epithelium covering the body surface and skeletal muscles (at protein level). Expression is reduced during differentiation of ES cells. In adult primary myoblasts, barely detectable during proliferation, but dramatically up-regulated during terminal differentiation. Induced as early as 24 hours after differentiation signal and remains high as late as 7 days of differentiation. Little expression in resting muscle, but strongly up-regulated during regeneration of skeletal muscle fibers. Expression decreases when regeneration is histologically and functionally complete. Negatively regulated by the microRNA miR-125b in response to retinoic acid. The CSD domain is required for function in muscle differentiation. The CCHC zinc fingers interact with the GGAG motif at the 3' end of let-7 miRNAs precursors, more generally they bind the 5'-NGNNG- 3' consensus motif with micromolar affinity. The CSD domain recognizes the loop at the 5' end. The flexible linker allows accommodating variable sequences and lengths among let-7 family members. Reactivation of LIN28A expression enhances tissue repair in some adult tissues by reprogramming cellular bioenergetics. Improves hair regrowth by promoting anagen in hair follicle and accelerates regrowth of cartilage, bone and mesenchyme after ear and digit injuries. Belongs to the lin-28 family. P-body G-quadruplex RNA binding nucleic acid binding RNA binding mRNA binding protein binding nucleus nucleolus cytoplasm endoplasmic reticulum rough endoplasmic reticulum polysome germ cell development zinc ion binding cytoplasmic stress granule miRNA metabolic process miRNA catabolic process negative regulation of translation stem cell population maintenance gene silencing by RNA pre-miRNA processing RNA 3'-end processing translation initiation factor binding positive regulation of TOR signaling miRNA binding positive regulation of neuron differentiation negative regulation of glial cell differentiation positive regulation of translation metal ion binding stem cell differentiation positive regulation of protein kinase B signaling regulation of gene silencing by miRNA cellular response to glucose stimulus positive regulation of cell proliferation involved in kidney development positive regulation of production of miRNAs involved in gene silencing by miRNA polysome binding sequence-specific mRNA binding ribonucleoprotein complex positive regulation of cytoplasmic translation uc008vdw.1 uc008vdw.2 uc008vdw.3 
ENSMUST00000051676.7 Tent5b ENSMUST00000051676.7 terminal nucleotidyltransferase 5B (from RefSeq NM_175307.6) ENSMUST00000051676.1 ENSMUST00000051676.2 ENSMUST00000051676.3 ENSMUST00000051676.4 ENSMUST00000051676.5 ENSMUST00000051676.6 Fam46b NM_175307 Q3TSC3 Q8C152 Q8CI10 TET5B_MOUSE Tent5b uc008vct.1 uc008vct.2 uc008vct.3 uc008vct.4 Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP hydrolysis-dependent manner. May be involved in maintaining the translation efficiency of at least some genes through preventing degradation of their mRNAs. Prefers RNA molecules that are adenosine- rich close to 3'-end. In addition, may inhibit cell proliferation and cell cycle progression through ubiquitination of beta-catenin/CTNNB1. Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, ChEBI:CHEBI:173115; EC=2.7.7.19; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11333; Evidence=; Cytoplasm Nucleus Belongs to the TENT family. It is uncertain whether Met-1 or Met-2 is the initiator. Sequence=AAH38001.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component biological_process transferase activity nucleotidyltransferase activity RNA adenylyltransferase activity uc008vct.1 uc008vct.2 uc008vct.3 uc008vct.4 
ENSMUST00000051691.8 Slk ENSMUST00000051691.8 STE20-like kinase, transcript variant 1 (from RefSeq NM_009289.3) A2RRK4 ENSMUST00000051691.1 ENSMUST00000051691.2 ENSMUST00000051691.3 ENSMUST00000051691.4 ENSMUST00000051691.5 ENSMUST00000051691.6 ENSMUST00000051691.7 Kiaa0204 NM_009289 O54988 Q80U65 Q8CAU2 Q8CDW2 Q9WU41 SLK_MOUSE Stk2 uc008hvf.1 uc008hvf.2 uc008hvf.3 uc008hvf.4 Mediates apoptosis and actin stress fiber dissolution. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O54988-1; Sequence=Displayed; Name=2; IsoId=O54988-2; Sequence=VSP_018101; Ubiquitously expressed. Ubiquitously expressed from day 7 to 17 dpc. Proteolytically cleaved by caspase-3. Autophosphorylated. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Sequence=BAC65500.1; Type=Erroneous initiation; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm protein phosphorylation apoptotic process kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation regulation of cell migration cytoplasmic microtubule organization cell leading edge activation of protein kinase activity positive regulation of histone phosphorylation identical protein binding protein homodimerization activity regulation of apoptotic process positive regulation of apoptotic process protein autophosphorylation perinuclear region of cytoplasm regulation of focal adhesion assembly uc008hvf.1 uc008hvf.2 uc008hvf.3 uc008hvf.4 
ENSMUST00000051704.15 Cit ENSMUST00000051704.15 citron (from RefSeq NM_007708.3) Cit E9QL53 E9QL53_MOUSE ENSMUST00000051704.1 ENSMUST00000051704.10 ENSMUST00000051704.11 ENSMUST00000051704.12 ENSMUST00000051704.13 ENSMUST00000051704.14 ENSMUST00000051704.2 ENSMUST00000051704.3 ENSMUST00000051704.4 ENSMUST00000051704.5 ENSMUST00000051704.6 ENSMUST00000051704.7 ENSMUST00000051704.8 ENSMUST00000051704.9 NM_007708 uc008zer.1 uc008zer.2 uc008zer.3 uc008zer.4 Plays a role in cytokinesis. Displays serine/threonine protein kinase activity. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Cytoplasm Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. G2/M transition of mitotic cell cycle nucleotide binding mitotic cytokinesis liver development protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytosol plasma membrane protein phosphorylation Golgi organization regulation of actin polymerization or depolymerization kinase activity phosphorylation transferase activity PDZ domain binding midbody Golgi cisterna cleavage furrow positive regulation of cytokinesis intracellular signal transduction neuronal cell body metal ion binding neuron apoptotic process scaffold protein binding uc008zer.1 uc008zer.2 uc008zer.3 uc008zer.4 
ENSMUST00000051705.7 Kcne1 ENSMUST00000051705.7 potassium voltage-gated channel, Isk-related subfamily, member 1 (from RefSeq NM_008424.3) ENSMUST00000051705.1 ENSMUST00000051705.2 ENSMUST00000051705.3 ENSMUST00000051705.4 ENSMUST00000051705.5 ENSMUST00000051705.6 Kcne1 NM_008424 Q545H6 Q545H6_MOUSE uc007zzb.1 uc007zzb.2 uc007zzb.3 Apical cell membrane Membrane raft Belongs to the potassium channel KCNE family. voltage-gated potassium channel activity delayed rectifier potassium channel activity endoplasmic reticulum Golgi apparatus plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex male gonad development potassium channel regulator activity membrane integral component of membrane apical plasma membrane Z disc ion channel binding protein heterodimerization activity cellular response to acidic pH cellular response to light stimulus potassium ion transmembrane transport negative regulation of protein targeting to membrane positive regulation of potassium ion transmembrane transport positive regulation of voltage-gated calcium channel activity negative regulation of delayed rectifier potassium channel activity negative regulation of voltage-gated potassium channel activity positive regulation of voltage-gated potassium channel activity uc007zzb.1 uc007zzb.2 uc007zzb.3 
ENSMUST00000051706.6 Ddi1 ENSMUST00000051706.6 DNA-damage inducible 1 (from RefSeq NM_027942.1) DDI1_MOUSE ENSMUST00000051706.1 ENSMUST00000051706.2 ENSMUST00000051706.3 ENSMUST00000051706.4 ENSMUST00000051706.5 NM_027942 Q9DAF3 uc009oca.1 uc009oca.2 uc009oca.3 Probable aspartic protease (By similarity). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity). Belongs to the DDI1 family. aspartic-type endopeptidase activity cellular_component proteolysis peptidase activity proteasomal protein catabolic process hydrolase activity regulation of protein stability cellular response to hydroxyurea uc009oca.1 uc009oca.2 uc009oca.3 
ENSMUST00000051714.9 Lypd10 ENSMUST00000051714.9 Ly6/PLAUR domain containing 10, transcript variant 2 (from RefSeq NM_199150.2) BC049730 ENSMUST00000051714.1 ENSMUST00000051714.2 ENSMUST00000051714.3 ENSMUST00000051714.4 ENSMUST00000051714.5 ENSMUST00000051714.6 ENSMUST00000051714.7 ENSMUST00000051714.8 Lypd10 NM_199150 Q810N3 Q810N3_MOUSE uc009fqj.1 uc009fqj.2 molecular_function cellular_component biological_process uc009fqj.1 uc009fqj.2 
ENSMUST00000051720.6 Sh3tc2 ENSMUST00000051720.6 SH3 domain and tetratricopeptide repeats 2 (from RefSeq NM_172628.3) ENSMUST00000051720.1 ENSMUST00000051720.2 ENSMUST00000051720.3 ENSMUST00000051720.4 ENSMUST00000051720.5 Kiaa1985 NM_172628 Q80VA5 Q8BWH2 Q8BXB8 Q8C0G6 S3TC2_MOUSE uc008fcv.1 uc008fcv.2 uc008fcv.3 Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80VA5-1; Sequence=Displayed; Name=2; IsoId=Q80VA5-2; Sequence=VSP_009887, VSP_009892; Name=3; IsoId=Q80VA5-3; Sequence=VSP_009888, VSP_009889; Name=4; IsoId=Q80VA5-4; Sequence=VSP_009890, VSP_009891; protein binding plasma membrane myelination in peripheral nervous system cytoplasmic vesicle peripheral nervous system myelin maintenance regulation of intracellular protein transport recycling endosome regulation of ERBB signaling pathway uc008fcv.1 uc008fcv.2 uc008fcv.3 
ENSMUST00000051737.8 Ap1ar ENSMUST00000051737.8 adaptor-related protein complex 1 associated regulatory protein, transcript variant 1 (from RefSeq NM_145964.4) Ap1ar E9PYF7 E9PYF7_MOUSE ENSMUST00000051737.1 ENSMUST00000051737.2 ENSMUST00000051737.3 ENSMUST00000051737.4 ENSMUST00000051737.5 ENSMUST00000051737.6 ENSMUST00000051737.7 NM_145964 uc008rhp.1 uc008rhp.2 uc008rhp.3 uc008rhp.4 negative regulation of receptor recycling endosome Golgi apparatus cytosol kinesin binding transport vesicle regulation of Arp2/3 complex-mediated actin nucleation cellular protein localization AP-1 adaptor complex binding vesicle targeting, trans-Golgi to endosome Arp2/3 complex binding negative regulation of substrate adhesion-dependent cell spreading negative regulation of cell motility uc008rhp.1 uc008rhp.2 uc008rhp.3 uc008rhp.4 
ENSMUST00000051754.2 Pcdhb3 ENSMUST00000051754.2 protocadherin beta 3 (from RefSeq NM_053128.2) ENSMUST00000051754.1 NM_053128 Pcdhb3 Q91XZ7 Q91XZ7_MOUSE uc008epo.1 uc008epo.2 calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epo.1 uc008epo.2 
ENSMUST00000051756.8 Il31ra ENSMUST00000051756.8 interleukin 31 receptor A (from RefSeq NM_139299.2) E9QQ31 ENSMUST00000051756.1 ENSMUST00000051756.2 ENSMUST00000051756.3 ENSMUST00000051756.4 ENSMUST00000051756.5 ENSMUST00000051756.6 ENSMUST00000051756.7 Glmr IL31R_MOUSE NM_139299 Q6EAL6 Q6EAL7 Q6NZF0 Q8BSU3 Q8K5B1 Q8R501 uc007rwi.1 uc007rwi.2 uc007rwi.3 uc007rwi.4 Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (PubMed:24373353). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (PubMed:17379091). Heterodimer with OSMR. Interacts with JAK1 and STAT3. Cell membrane ; Single-pass type I membrane protein Presynaptic cell membrane Cell projection, axon Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8K5B1-1; Sequence=Displayed; Name=2; Synonyms=muZcytoR17x1; IsoId=Q8K5B1-2; Sequence=VSP_022815, VSP_022821, VSP_022822; Name=3; Synonyms=muZcytoR17x2; IsoId=Q8K5B1-3; Sequence=VSP_022815, VSP_022819, VSP_022820; Name=4; IsoId=Q8K5B1-4; Sequence=VSP_022816, VSP_022817, VSP_022818; Name=5; IsoId=Q8K5B1-5; Sequence=VSP_022814; Expressed in a subset of dorsal root ganglia neurons (PubMed:16926070, PubMed:24373353, PubMed:25381841). Expressed in spinal cord and trigeminal ganglion (at protein level) (PubMed:25381841). Expressed in skin, testis, bone marrow and thymus (PubMed:15184896). Primarily expressed at postnatal day 10 in the dorsal root ganglia where expression gradually increases as the development proceed. Up-regulated in the diseased tissues of a mouse models of allergic asthma and airway hypersensitivity (PubMed:15184896, PubMed:25847241). Up-regulated by IL31 in dorsal root ganglia (PubMed:25381841). Up-regulated by Th2 cytokines IL4 and IL13 in macrophages (PubMed:25847241). N-glycosylated. Mice do not develop dermatitis upon Il31 overexpression (PubMed:15184896). Decreased levels of immature myeloid progenitor cells in bone marrow and spleen but normal numbers of circulating blood cells (PubMed:17379091). Belongs to the type I cytokine receptor family. Type 2 subfamily. glandular epithelial cell differentiation immune system process acute inflammatory response to antigenic stimulus cytokine receptor activity plasma membrane JAK-STAT cascade positive regulation of cell proliferation external side of plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway cytokine binding cell junction monocyte differentiation axon T-helper 2 cell cytokine production positive regulation of tyrosine phosphorylation of STAT protein presynaptic membrane cell projection receptor complex synapse defense response to other organism uc007rwi.1 uc007rwi.2 uc007rwi.3 uc007rwi.4 
ENSMUST00000051757.14 Slc26a1 ENSMUST00000051757.14 solute carrier family 26 (sulfate transporter), member 1, transcript variant 2 (from RefSeq NM_174870.4) ENSMUST00000051757.1 ENSMUST00000051757.10 ENSMUST00000051757.11 ENSMUST00000051757.12 ENSMUST00000051757.13 ENSMUST00000051757.2 ENSMUST00000051757.3 ENSMUST00000051757.4 ENSMUST00000051757.5 ENSMUST00000051757.6 ENSMUST00000051757.7 ENSMUST00000051757.8 ENSMUST00000051757.9 NM_174870 Q3UPH6 Q3UPH6_MOUSE Slc26a1 uc008yoz.1 uc008yoz.2 uc008yoz.3 uc008yoz.4 uc008yoz.5 uc008yoz.6 uc008yoz.7 Sodium-independent sulfate anion transporter. Can transport other anions including bicarbonate, thiosulfate and oxalate. Cell membrane ; Multi-pass membrane protein Membrane ; Multi- pass membrane protein Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. integral component of plasma membrane chloride transport secondary active sulfate transmembrane transporter activity sulfate transport chloride transmembrane transporter activity sulfate transmembrane transporter activity antiporter activity anion:anion antiporter activity membrane integral component of membrane oxalate transmembrane transporter activity oxalate transport transmembrane transport anion transmembrane transport sulfate transmembrane transport chloride transmembrane transport uc008yoz.1 uc008yoz.2 uc008yoz.3 uc008yoz.4 uc008yoz.5 uc008yoz.6 uc008yoz.7 
ENSMUST00000051758.11 Vkorc1l1 ENSMUST00000051758.11 vitamin K epoxide reductase complex, subunit 1-like 1, transcript variant 1 (from RefSeq NM_027121.4) ENSMUST00000051758.1 ENSMUST00000051758.10 ENSMUST00000051758.2 ENSMUST00000051758.3 ENSMUST00000051758.4 ENSMUST00000051758.5 ENSMUST00000051758.6 ENSMUST00000051758.7 ENSMUST00000051758.8 ENSMUST00000051758.9 NM_027121 Q05AD4 Q6TEK5 VKORL_MOUSE uc008ztr.1 uc008ztr.2 uc008ztr.3 uc008ztr.4 Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K, and may contribute to vitamin K- mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins. Reaction=[protein]-disulfide + H2O + phylloquinone = 2,3- epoxyphylloquinone + [protein]-dithiol; Xref=Rhea:RHEA:13817, Rhea:RHEA-COMP:10593, Rhea:RHEA-COMP:10594, ChEBI:CHEBI:15377, ChEBI:CHEBI:15759, ChEBI:CHEBI:18067, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058; EC=1.17.4.4; Evidence=; Reaction=[protein]-disulfide + phylloquinol = [protein]-dithiol + phylloquinone; Xref=Rhea:RHEA:57744, Rhea:RHEA-COMP:10593, Rhea:RHEA- COMP:10594, ChEBI:CHEBI:18067, ChEBI:CHEBI:28433, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058; EC=1.17.4.4; Evidence=; Inhibited by warfarin (coumadin) (PubMed:23928358). Warfarin locks VKORC1 in both redox states into the closed conformation (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Detected in testis and lung. Vkorc1l1 overexpression cannot rescue the lethal phenotype of Vkorc1-deficient mice, suggesting that the protein does not play a major role in vitamin K-dependent blood coagulation. Belongs to the VKOR family. endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane oxidoreductase activity peptidyl-glutamic acid carboxylation cellular response to oxidative stress vitamin K metabolic process vitamin-K-epoxide reductase (warfarin-sensitive) activity quinone binding oxidation-reduction process uc008ztr.1 uc008ztr.2 uc008ztr.3 uc008ztr.4 
ENSMUST00000051765.9 Glp2r ENSMUST00000051765.9 glucagon-like peptide 2 receptor (from RefSeq NM_175681.3) ENSMUST00000051765.1 ENSMUST00000051765.2 ENSMUST00000051765.3 ENSMUST00000051765.4 ENSMUST00000051765.5 ENSMUST00000051765.6 ENSMUST00000051765.7 ENSMUST00000051765.8 GLP2R_MOUSE NM_175681 Q5IXF8 Q5SU65 uc007jna.1 uc007jna.2 This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 2 family. transmembrane signaling receptor activity G-protein coupled receptor activity glucagon receptor activity plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane peptide hormone binding cellular response to glucagon stimulus uc007jna.1 uc007jna.2 
ENSMUST00000051772.10 Morn4 ENSMUST00000051772.10 MORN repeat containing 4 (from RefSeq NM_198108.2) ENSMUST00000051772.1 ENSMUST00000051772.2 ENSMUST00000051772.3 ENSMUST00000051772.4 ENSMUST00000051772.5 ENSMUST00000051772.6 ENSMUST00000051772.7 ENSMUST00000051772.8 ENSMUST00000051772.9 MORN4_MOUSE NM_198108 Q6PGF2 uc008hne.1 uc008hne.2 uc008hne.3 Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. Interacts with MYO3A. Cytoplasm Cell projection, filopodium tip Cell projection, stereocilium Note=Found in the cytoplasm in the absence of MYO3A and localizes at filopodial tips in the presence of MYO3A. Severed Morn4 null axons show significantly reduced and delayed axonal degeneration following axotomy and protection is evident for at least 72 hrs, whereas wild-type axons degenerate within the first 12 hrs. protein binding cytoplasm stereocilium stereocilium tip filopodium tip cell projection response to axon injury uc008hne.1 uc008hne.2 uc008hne.3 
ENSMUST00000051773.9 Onecut3 ENSMUST00000051773.9 one cut domain, family member 3 (from RefSeq NM_139226.3) ENSMUST00000051773.1 ENSMUST00000051773.2 ENSMUST00000051773.3 ENSMUST00000051773.4 ENSMUST00000051773.5 ENSMUST00000051773.6 ENSMUST00000051773.7 ENSMUST00000051773.8 NM_139226 ONEC3_MOUSE Q6PDH9 Q8K557 uc007gdn.1 uc007gdn.2 uc007gdn.3 uc007gdn.4 Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Nucleus Specifically expressed in brain, stomach and gut. Within the gut, expressed only in duodenum and jejunum. Expressed in the endoderm from the 14-somite stage. Aroound 9.5 dpc, present in the ventral prepancreatic and prehepatic regions (at protein level). At 14.5 dpc, expressed in brain, stomach and gut. Transcriptionally regulated by ONECUT1 in the developing endoderm. Belongs to the CUT homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex cytosol regulation of transcription from RNA polymerase II promoter cell differentiation endocrine pancreas development positive regulation of transcription from RNA polymerase II promoter uc007gdn.1 uc007gdn.2 uc007gdn.3 uc007gdn.4 
ENSMUST00000051777.15 C2cd3 ENSMUST00000051777.15 C2 calcium-dependent domain containing 3 (from RefSeq NM_001017985.3) C2CD3_MOUSE E9QL99 ENSMUST00000051777.1 ENSMUST00000051777.10 ENSMUST00000051777.11 ENSMUST00000051777.12 ENSMUST00000051777.13 ENSMUST00000051777.14 ENSMUST00000051777.2 ENSMUST00000051777.3 ENSMUST00000051777.4 ENSMUST00000051777.5 ENSMUST00000051777.6 ENSMUST00000051777.7 ENSMUST00000051777.8 ENSMUST00000051777.9 Hty NM_001017985 Q3UFQ3 Q52KB6 Q80V48 Q8BXE5 uc029wni.1 uc029wni.2 uc029wni.3 Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation (PubMed:24469809). Required for primary cilium formation. Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3 (PubMed:19004860). Interacts with OFD1; OFD1 may act as a negative regulator of C2CD3. Associates with the BBSome complex (By similarity). Interacts with IFT88, BBS4 and PCM1. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to centrioles and procentrioles both in interphase and mitosis. Localizes to centriolar satellites, localization is dependent on PCM1 and dynein-mediated retrograde transport. Also localizes to the distal ends of the mother and daughter centrioles (PubMed:24469809). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q52KB6-1; Sequence=Displayed; Name=2; IsoId=Q52KB6-2; Sequence=VSP_029449, VSP_029450; Name=3; IsoId=Q52KB6-3; Sequence=VSP_029451, VSP_029452; Ubiquitously expressed in embryos between 8.5 dpc and 10.5 dpc. Embryonic lethality between 11 dpc and 13 dpc. Embryos show multiple defects including neural tube defects, abnormal dorsal-ventral patterning of the spinal cord, a defect in left-right axis determination and severe polydactyly (extra digits). Sequence=AAH94430.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; in utero embryonic development heart looping protein binding cytoplasm centrosome centriole cytoskeleton cilium pattern specification process brain development regulation of smoothened signaling pathway protein processing neural tube development neural plate axis specification cell projection organization regulation of proteolysis embryonic limb morphogenesis centriolar satellite ciliary basal body embryonic digit morphogenesis cell projection cilium assembly centriole elongation protein localization to centrosome non-motile cilium assembly uc029wni.1 uc029wni.2 uc029wni.3 
ENSMUST00000051784.10 Fastkd3 ENSMUST00000051784.10 FAST kinase domains 3, transcript variant 2 (from RefSeq NM_027123.5) ENSMUST00000051784.1 ENSMUST00000051784.2 ENSMUST00000051784.3 ENSMUST00000051784.4 ENSMUST00000051784.5 ENSMUST00000051784.6 ENSMUST00000051784.7 ENSMUST00000051784.8 ENSMUST00000051784.9 FAKD3_MOUSE NM_027123 Q5XKD3 Q6P9N4 Q8BSN9 Q8CB52 Q8CCG7 uc007rca.1 uc007rca.2 uc007rca.3 Required for normal mitochondrial respiration. Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity. Mitochondrion Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BSN9-1; Sequence=Displayed; Name=2; IsoId=Q8BSN9-2; Sequence=VSP_024625, VSP_024626; Name=3; IsoId=Q8BSN9-3; Sequence=VSP_024624; Expression detected in spleen, testis, colon, heart, smooth muscle, kidney, brain, lung, liver, brown and white adipose tissue with highest expression in testis and smooth muscle. RAP domain is required for FASTKD3 function in mRNA stability and translation. Belongs to the FAST kinase family. Sequence=BAC27277.1; Type=Frameshift; Evidence=; protein kinase activity nucleus mitochondrion protein phosphorylation mitochondrial respiratory chain complex IV assembly regulation of mitochondrial mRNA stability cellular respiration positive regulation of mitochondrial translation uc007rca.1 uc007rca.2 uc007rca.3 
ENSMUST00000051803.8 Aldh3b1 ENSMUST00000051803.8 aldehyde dehydrogenase 3 family, member B1 (from RefSeq NM_026316.3) AL3B1_MOUSE Aldh7 ENSMUST00000051803.1 ENSMUST00000051803.2 ENSMUST00000051803.3 ENSMUST00000051803.4 ENSMUST00000051803.5 ENSMUST00000051803.6 ENSMUST00000051803.7 NM_026316 Q63ZW3 Q80VQ0 Q8VHW0 Q9CW05 uc008fxq.1 uc008fxq.2 uc008fxq.3 uc008fxq.4 Oxidizes medium and long chain saturated and unsaturated aldehydes (PubMed:25286108). Metabolizes also benzaldehyde (By similarity). Low activity towards acetaldehyde and 3,4- dihydroxyphenylacetaldehyde (By similarity). May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor (By similarity). May have a protective role against the cytotoxicity induced by lipid peroxidation (By similarity). Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.5; Evidence=; Reaction=an aldehyde + H2O + NADP(+) = a carboxylate + 2 H(+) + NADPH; Xref=Rhea:RHEA:11888, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.2.1.5; Evidence=; Reaction=2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+); Xref=Rhea:RHEA:33739, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17600, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate; Xref=Rhea:RHEA:44100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:25646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence= Reaction=H2O + NADP(+) + octanal = 2 H(+) + NADPH + octanoate; Xref=Rhea:RHEA:59904, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:25646, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Reaction=benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH; Xref=Rhea:RHEA:21660, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16150, ChEBI:CHEBI:17169, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.2.1.7; Evidence=; Reaction=benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH; Xref=Rhea:RHEA:11840, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16150, ChEBI:CHEBI:17169, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.28; Evidence=; Reaction=H2O + hexanal + NADP(+) = 2 H(+) + hexanoate + NADPH; Xref=Rhea:RHEA:59908, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88528; Evidence=; Reaction=(E)-4-hydroxynon-2-enal + H2O + NADP(+) = (E)-4-hydroxynon-2- enoate + 2 H(+) + NADPH; Xref=Rhea:RHEA:59912, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58968, ChEBI:CHEBI:142920; Evidence=; Reaction=(2E)-octenal + H2O + NADP(+) = (2E)-octenoate + 2 H(+) + NADPH; Xref=Rhea:RHEA:59916, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61748, ChEBI:CHEBI:143526; Evidence=; Reaction=(2E)-octenal + H2O + NAD(+) = (2E)-octenoate + 2 H(+) + NADH; Xref=Rhea:RHEA:59920, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:61748, ChEBI:CHEBI:143526; Evidence=; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. Cell membrane ; Lipid-anchor Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm. Highly expressed in kidney and liver. In brain is expressed at moderate levels in cortex, striatum and hippocampus, and at lower levels in brainstem and cerebellum. Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates. Belongs to the aldehyde dehydrogenase family. 3-chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity aldehyde dehydrogenase [NAD(P)+] activity cytoplasm cytosol plasma membrane ethanol catabolic process cellular aldehyde metabolic process membrane oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor benzaldehyde dehydrogenase (NADP+) activity benzaldehyde dehydrogenase (NAD+) activity cellular response to oxidative stress aldehyde catabolic process oxidation-reduction process uc008fxq.1 uc008fxq.2 uc008fxq.3 uc008fxq.4 
ENSMUST00000051809.10 Myct1 ENSMUST00000051809.10 myc target 1 (from RefSeq NM_026793.2) ENSMUST00000051809.1 ENSMUST00000051809.2 ENSMUST00000051809.3 ENSMUST00000051809.4 ENSMUST00000051809.5 ENSMUST00000051809.6 ENSMUST00000051809.7 ENSMUST00000051809.8 ENSMUST00000051809.9 MYCT1_MOUSE Mtmc1 NM_026793 Q3UQ11 Q8C6M8 Q8R411 Q9D182 uc007egl.1 uc007egl.2 uc007egl.3 uc007egl.4 uc007egl.5 May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability and inhibition of hematopoietic differentiation. Nucleus membrane ; Single-pass membrane protein Highly expressed in lung, heart, and skeletal muscle. Expressed in brain, eye, liver, kidney, smooth muscle, pancreas, thyroid, thymus, submaxillary gland, spleen, testis, ovary, prostate, epididymis, and uterus. Deregulated expression promotes apoptosis in response to growth factor deprivation. Overexpression in synergy with CCNB1 may promote genomic instability. Low levels of expression seen in 7-, 11-, 15- and 17-day embryos. Belongs to the MYCT1 family. Sequence=BAC35696.1; Type=Erroneous initiation; Evidence=; Sequence=BAE25233.1; Type=Frameshift; Evidence=; molecular_function nucleus nucleoplasm biological_process membrane integral component of membrane nuclear membrane intracellular membrane-bounded organelle uc007egl.1 uc007egl.2 uc007egl.3 uc007egl.4 uc007egl.5 
ENSMUST00000051822.13 Skic8 ENSMUST00000051822.13 SKI8 subunit of superkiller complex, transcript variant 2 (from RefSeq NM_023191.3) ENSMUST00000051822.1 ENSMUST00000051822.10 ENSMUST00000051822.11 ENSMUST00000051822.12 ENSMUST00000051822.2 ENSMUST00000051822.3 ENSMUST00000051822.4 ENSMUST00000051822.5 ENSMUST00000051822.6 ENSMUST00000051822.7 ENSMUST00000051822.8 ENSMUST00000051822.9 NM_023191 Q3U562 Q9CZP1 Q9ERF3 SKI8_MOUSE Wdr61 uc009pro.1 uc009pro.2 uc009pro.3 uc009pro.4 Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency (PubMed:19345177). PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1 (By similarity). PAF1C is required for transcription of Hox and Wnt target genes (By similarity). PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL (By similarity). PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription (By similarity). PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors (By similarity). In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription (By similarity). Required for mono- and trimethylation on histone H3 'Lys- 4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3) (By similarity). Required for Hox gene transcription (By similarity). Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality- control pathways (By similarity). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (By similarity). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (By similarity). Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and SKIC8. The PAF1 complex interacts with PHF5A (PubMed:27749823). Within the PAF1 complex interacts directly with PHF5A (PubMed:27749823). Component of the SKI complex which consists of SKIC2, SKIC3 and SKIC8 (By similarity). Nucleus Cytoplasm Belongs to the SKI8 family. molecular_function protein binding nucleus nucleoplasm cytoplasm cytosol Wnt signaling pathway Cdc73/Paf1 complex positive regulation of transcription elongation from RNA polymerase II promoter transcriptionally active chromatin negative regulation of myeloid cell differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of histone H3-K4 methylation Ski complex histone H3-K4 trimethylation positive regulation of histone H3-K79 methylation uc009pro.1 uc009pro.2 uc009pro.3 uc009pro.4 
ENSMUST00000051839.9 Hepacam ENSMUST00000051839.9 hepatocyte cell adhesion molecule (from RefSeq NM_175189.4) ENSMUST00000051839.1 ENSMUST00000051839.2 ENSMUST00000051839.3 ENSMUST00000051839.4 ENSMUST00000051839.5 ENSMUST00000051839.6 ENSMUST00000051839.7 ENSMUST00000051839.8 HECAM_MOUSE Hepacam NM_175189 Q640R3 uc009our.1 uc009our.2 uc009our.3 uc009our.4 Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (By similarity). Homodimer. Dimer formation occurs predominantly through cis interactions on the cell surface (By similarity). Part of a complex containing MLC1, TRPV4, AQP4 and ATP1B1 (By similarity). Cytoplasm. Membrane ; Single-pass type I membrane protein ; Cytoplasmic side Note=Colocalizes with CDH1. The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility. N-glycosylated. protein binding cytoplasm cell-cell junction cell cycle cell cycle arrest cell adhesion membrane integral component of membrane axon cellular protein localization regulation of growth uc009our.1 uc009our.2 uc009our.3 uc009our.4 
ENSMUST00000051846.13 Cyp2c70 ENSMUST00000051846.13 cytochrome P450, family 2, subfamily c, polypeptide 70 (from RefSeq NM_145499.2) CP270_MOUSE Cyp2c-70 Cyp2c22 Cyp2c70 ENSMUST00000051846.1 ENSMUST00000051846.10 ENSMUST00000051846.11 ENSMUST00000051846.12 ENSMUST00000051846.2 ENSMUST00000051846.3 ENSMUST00000051846.4 ENSMUST00000051846.5 ENSMUST00000051846.6 ENSMUST00000051846.7 ENSMUST00000051846.8 ENSMUST00000051846.9 NM_145499 Q5GLY9 Q80VW0 Q8R120 Q8VC00 Q91W64 uc008hkj.1 uc008hkj.2 uc008hkj.3 uc008hkj.4 A cytochrome P450 monooxygenase involved in muricholic acid (MCA) synthesis (PubMed:27638959). Hydroxylates at the 6-beta position two major bile acids, chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) to form alpha-MCA and beta-MCA, respectively (PubMed:27638959). May regulate NR1H4/farnesoid X receptor signaling, as taurine-conjugated MCAs are antagonists of NR1H4. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:27638959). Reaction=chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = alpha-muricholate + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:51448, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:36234, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134116; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51449; Evidence=; Reaction=O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate = beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51452, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78604, ChEBI:CHEBI:134119; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51453; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Expressed in liver. Belongs to the cytochrome P450 family. Sequence=AAH25822.1; Type=Erroneous initiation; Evidence=; monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding organelle membrane exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc008hkj.1 uc008hkj.2 uc008hkj.3 uc008hkj.4 
ENSMUST00000051849.10 Slc9b2 ENSMUST00000051849.10 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2, transcript variant 1 (from RefSeq NM_178877.7) ENSMUST00000051849.1 ENSMUST00000051849.2 ENSMUST00000051849.3 ENSMUST00000051849.4 ENSMUST00000051849.5 ENSMUST00000051849.6 ENSMUST00000051849.7 ENSMUST00000051849.8 ENSMUST00000051849.9 NM_178877 Nha2 Nhe10 Nhedc2 Q5BKR2 Q8CA47 Q8CDX4 SL9B2_MOUSE Slc9b2 uc008rld.1 uc008rld.2 uc008rld.3 uc008rld.4 Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18508966, PubMed:17988971). Uses the proton gradient/membrane potential to extrude sodium (By similarity). Contributes to the regulation of intracellular pH and sodium homeostasis (PubMed:27909897). Also able to mediate Na(+)/Li(+) antiporter activity in kidney (By similarity). May play a physiological role in renal tubular function and blood pressure homeostasis (PubMed:32956652, PubMed:27909897). Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (PubMed:23720317). Involved in sperm motility and fertility (PubMed:27010853). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (PubMed:20441802, PubMed:17988971). Reaction=H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out); Xref=Rhea:RHEA:29419, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101; Evidence=; Reaction=H(+)(in) + Li(+)(out) = H(+)(out) + Li(+)(in); Xref=Rhea:RHEA:72407, ChEBI:CHEBI:15378, ChEBI:CHEBI:49713; Evidence=; Reaction=Li(+)(in) + Na(+)(out) = Li(+)(out) + Na(+)(in); Xref=Rhea:RHEA:72415, ChEBI:CHEBI:29101, ChEBI:CHEBI:49713; Evidence=; Allosterically inhibited by the N-terminal domain. Inhibited by phloretin. Homodimer; dimerization is essential for SLC9B2 activity. Lipids seem to play a role in the stabilization of the dimerization subdomain. Cell membrane ulti-pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Note=Strong colocalization with LAMP1 and TCIRG1 in osteoclasts (PubMed:20441802). In beta-cells colocalizes with RAB4A and SYP (PubMed:23720317). Localizes to the basolateral membrane of polarized osteoclasts (PubMed:20441802). Localizes to the apical membrane of distal convoluted and connecting tubules (PubMed:27909897). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5BKR2-1; Sequence=Displayed; Name=2; IsoId=Q5BKR2-2; Sequence=VSP_033155; Name=3; IsoId=Q5BKR2-3; Sequence=VSP_033154; Widely expressed (PubMed:18000046, PubMed:18508966, PubMed:17988971). However expression seems to be restricted to specific cell types within individual organs, e.g. osteoclasts in the bone, distal tubules of the kidney or beta-cells of Langerhans islets (PubMed:18508966, PubMed:17988971, PubMed:17698421, PubMed:23720317, PubMed:18269914, PubMed:32956652). In sperm specifically present in the principal piece of sperm tail (at protein level) (PubMed:27010853). Not detectable during the early stages of osteoclast differentiation induced by TNFSF11/RANKL (PubMed:17698421, PubMed:17988971). Up-regulated during the later stages of osteoclast differentiation (PubMed:20441802, PubMed:18508966, PubMed:17698421, PubMed:17988971). Up-regulated in macrophages and blood mononuclear cells treated with TNFSF11/RANKL. No visible phenotype. However males show reduced fertility caused by diminished sperm motility (PubMed:27010853). Deficient mice display a pathological glucose tolerance with impaired insulin secretion but normal peripheral insulin sensitivity (PubMed:23720317). Mutant have normal bone density and their bones are characterized by normal structural parameters (PubMed:20441802, PubMed:22985540). The subcellular localization of NHA2 remains controversial. Was initially thought to partially localize to mitochondria (PubMed:17988971). It was later established that its predominant localization is in endosomes and lysosomes (PubMed:20441802). In another recent study, endogenous SLC9B2 in the distal tubular cell line mpkDCT4 is detected in recycling endosomes but absent in plasma membrane (PubMed:32956652). Inhibited by phloretin but not by the classical SLC9A- inhibitor amiloride. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. mitochondrion mitochondrial inner membrane endosome plasma membrane cilium ion transport cation transport sodium ion transport endosome membrane lithium:proton antiporter activity antiporter activity solute:proton antiporter activity sodium:proton antiporter activity membrane integral component of membrane basolateral plasma membrane cell junction flagellated sperm motility synaptic vesicle membrane cytoplasmic vesicle motile cilium mitochondrial membrane sodium ion transmembrane transport identical protein binding cell projection synapse transmembrane transport regulation of insulin secretion involved in cellular response to glucose stimulus clathrin-dependent endocytosis sperm principal piece intracellular vesicle hydrogen ion transmembrane transport positive regulation of osteoclast development uc008rld.1 uc008rld.2 uc008rld.3 uc008rld.4 
ENSMUST00000051857.5 Insm2 ENSMUST00000051857.5 insulinoma-associated 2 (from RefSeq NM_020287.3) E9QNA9 ENSMUST00000051857.1 ENSMUST00000051857.2 ENSMUST00000051857.3 ENSMUST00000051857.4 INSM2_MOUSE Mlt1 NM_020287 Q9JMC2 uc007not.1 uc007not.2 uc007not.3 uc007not.4 May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons. Cytoplasm Nucleus Expressed in spleen, stomach, liver, kidney and testis. In the pancreas, expressed in islet cells, including insulin- producing beta-cells, but not in acinar cells (at protein level). In the brain, expressed in the neuronal cells of the cerebral cortex, the Purkinje cells of the cerebellum and the hippocampal region including CA1 and CA3 (at protein level). Expressed in 6.5 to 18.5 dpc embryos and transiently up-regulated from 11.5 to 13.5 dpc. In the developing brain, up-regulated 2 weeks postnatally, with gradual decrease thereafter. Still detectable at 52 weeks. Up-regulated by NEUROG3 and NEUROD1. negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription corepressor activity nucleus cytoplasm regulation of cell cycle process transcriptional repressor complex neuron differentiation negative regulation of transcription, DNA-templated metal ion binding uc007not.1 uc007not.2 uc007not.3 uc007not.4 
ENSMUST00000051862.8 Erich3 ENSMUST00000051862.8 glutamate rich 3 (from RefSeq NM_175176.3) ENSMUST00000051862.1 ENSMUST00000051862.2 ENSMUST00000051862.3 ENSMUST00000051862.4 ENSMUST00000051862.5 ENSMUST00000051862.6 ENSMUST00000051862.7 ERIC3_MOUSE Erich3 F6QRE9 NM_175176 Q8BVT3 uc008rur.1 uc008rur.2 uc008rur.3 Component of the primary cilium that controls cilium formation and length. May function within retrograde intraflagellar transport (IFT)-associated pathways to remove signaling proteins from primary cilia. Also involved in neuronal vesicle biogenesis and neurotransmitter vesicular function. Cell projection, cilium Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=F6QRE9-1; Sequence=Displayed; Name=2; IsoId=F6QRE9-2; Sequence=VSP_061973, VSP_061974, VSP_061975; molecular_function cellular_component biological_process uc008rur.1 uc008rur.2 uc008rur.3 
ENSMUST00000051869.8 Ccdc17 ENSMUST00000051869.8 coiled-coil domain containing 17 (from RefSeq NM_001037916.3) B0QZT6 CCD17_MOUSE ENSMUST00000051869.1 ENSMUST00000051869.2 ENSMUST00000051869.3 ENSMUST00000051869.4 ENSMUST00000051869.5 ENSMUST00000051869.6 ENSMUST00000051869.7 NM_001037916 Q8BTE7 Q8CE13 uc008ugu.1 uc008ugu.2 Sequence=CAQ11117.1; Type=Erroneous gene model prediction; Evidence=; molecular_function cellular_component biological_process uc008ugu.1 uc008ugu.2 
ENSMUST00000051870.8 Champ1 ENSMUST00000051870.8 Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore (By similarity). (from UniProt Q8K327) AK132164 CHAP1_MOUSE D8Ertd457e ENSMUST00000051870.1 ENSMUST00000051870.2 ENSMUST00000051870.3 ENSMUST00000051870.4 ENSMUST00000051870.5 ENSMUST00000051870.6 ENSMUST00000051870.7 Kiaa1802 Q3UZ85 Q6ZPI1 Q8K327 Zfp828 Znf828 uc009kyq.1 uc009kyq.2 uc009kyq.3 Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore (By similarity). Interacts with MAD2L2. Interacts with POGZ, CBX1, CBX3 and CBX5 (By similarity). Nucleus Chromosome Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Phosphorylated by CDK1. Mitotic phosphorylation is required for the attachment of spindle microtubules to the kinetochore (By similarity). Sequence=BAC98254.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed chromosome nucleic acid binding nucleus nucleoplasm chromosome cytoplasm spindle cytoskeleton sister chromatid biorientation protein localization to kinetochore protein localization to microtubule metal ion binding attachment of mitotic spindle microtubules to kinetochore Flemming body uc009kyq.1 uc009kyq.2 uc009kyq.3 
ENSMUST00000051874.6 Or2w4 ENSMUST00000051874.6 olfactory receptor family 2 subfamily W member 4 (from RefSeq NM_146744.2) ENSMUST00000051874.1 ENSMUST00000051874.2 ENSMUST00000051874.3 ENSMUST00000051874.4 ENSMUST00000051874.5 NM_146744 Olfr1362 Or2w4 Q5SZZ8 Q5SZZ8_MOUSE uc007pqv.1 uc007pqv.2 uc007pqv.3 uc007pqv.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript is intronless :: BC119336.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007pqv.1 uc007pqv.2 uc007pqv.3 uc007pqv.4 
ENSMUST00000051888.4 Borcs6 ENSMUST00000051888.4 BLOC-1 related complex subunit 6 (from RefSeq NM_028005.3) BORC6_MOUSE Borcs6 ENSMUST00000051888.1 ENSMUST00000051888.2 ENSMUST00000051888.3 NM_028005 Q3TE21 Q9D6W8 uc007jpb.1 uc007jpb.2 uc007jpb.3 As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. Lysosome membrane Belongs to the BORCS6 family. protein binding lysosome lysosomal membrane membrane lysosome localization BORC complex uc007jpb.1 uc007jpb.2 uc007jpb.3 
ENSMUST00000051906.13 Akap17b ENSMUST00000051906.13 A kinase anchor protein 17B, transcript variant 2 (from RefSeq NM_001419768.1) A2A3V1 AK17B_MOUSE B0QZD2 ENSMUST00000051906.1 ENSMUST00000051906.10 ENSMUST00000051906.11 ENSMUST00000051906.12 ENSMUST00000051906.2 ENSMUST00000051906.3 ENSMUST00000051906.4 ENSMUST00000051906.5 ENSMUST00000051906.6 ENSMUST00000051906.7 ENSMUST00000051906.8 ENSMUST00000051906.9 NM_001419768 Q0P534 Q8BR01 Q8C6P6 Sfrs17b uc009sxp.1 uc009sxp.2 uc009sxp.3 Splice factor regulating alternative splice site selection for certain mRNA precursors. Monomer. Component of the spliceosome (By similarity). Nucleus speckle Ubiquitously expressed. Uniformally expressed in the extraembryonic ectoderm at 5.5 dpc. Restricted to the distal part of the extraembryonic ectoderm at 6.5 dpc-7.5 dpc. 'Talia' means 'waistline' in Polish. Sequence=BAC35651.1; Type=Frameshift; Evidence=; Sequence=CAQ12496.1; Type=Erroneous gene model prediction; Evidence=; molecular_function nucleic acid binding RNA binding cellular_component nucleus spliceosomal complex mRNA processing biological_process RNA splicing nuclear speck uc009sxp.1 uc009sxp.2 uc009sxp.3 
ENSMUST00000051907.3 Spata21 ENSMUST00000051907.3 spermatogenesis associated 21 (from RefSeq NM_177867.3) ENSMUST00000051907.1 ENSMUST00000051907.2 NM_177867 Q8BHW6 SPT21_MOUSE uc008vnv.1 uc008vnv.2 uc008vnv.3 Involved in the differentiation of haploid spermatids. calcium ion binding cellular_component biological_process metal ion binding uc008vnv.1 uc008vnv.2 uc008vnv.3 
ENSMUST00000051912.13 Gas2 ENSMUST00000051912.13 growth arrest specific 2, transcript variant 2 (from RefSeq NM_001330607.2) ENSMUST00000051912.1 ENSMUST00000051912.10 ENSMUST00000051912.11 ENSMUST00000051912.12 ENSMUST00000051912.2 ENSMUST00000051912.3 ENSMUST00000051912.4 ENSMUST00000051912.5 ENSMUST00000051912.6 ENSMUST00000051912.7 ENSMUST00000051912.8 ENSMUST00000051912.9 GAS2_MOUSE Gas-2 NM_001330607 P11862 uc291qic.1 uc291qic.2 May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May play a role in chondrocyte proliferation and differentiation, and in limb myogenesis. May be involved in the regulation of the apoptosis in the interdigital tissues of the developing hindlimb. May be involved in the membrane ruffling process. Cytoplasm, cytoskeleton, stress fiber Membrane ; Peripheral membrane protein Note=Component of the microfilament system (PubMed:1607387). Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts (PubMed:8120096). Mainly membrane-associated (PubMed:8120096). When hyperphosphorylated, accumulates at membrane ruffles (PubMed:8120096). Expressed in most tissues. Highest levels in liver, lung and kidney. In the embryo strongly expressed in regions that undergo extensive apoptosis, such as the intervertebral tissues, the cranofacial mesenchyme and the cartilage of the limbs. At 11.5 dpc and 13.5 dpc strongly expressed in the soft connective tissue of the face and trunk, and in the invertebral tissues. Low levels are found in brain and neural tube. Low levels are found in 13.5 dpc lung, kidney, eye lens and in vertebral cartilage located cranially. In 11.5 dpc hindlimbs weakly expressed by the mesenchymal cells surrounding the perspective cartilage-forming regions. In 12.5 dpc hindlimbs strongly expressed by cells enveloping the chondrogenic primordia of the digits, metatarsals, tibia, and femur, and the soft connective tissue in the interdigital tissues. In 13.5 dpc hindlimbs expression is maintained in the intergigital tissues located proximally and is found in some chondrocytes in the stylopod and in mesenchymal cells surrounding the cartilage in the autopod and zygopod. In 13.5 dpc forelimb strongly expressed in the pre- hypertrophic and hypertrophic regions of the humerus, radius, and ulna. Expression in hypertrophic chondrocytes is maintained at 14.5 dpc and is not detectable at 15.5 dpc. At day 14.5 dpc also expressed by chondrocytes in the cartilage forming the carpals and tarsals and by mesenchymal cells in the process of condensing to form tendons. In 13.5 dpc hindlimbs expressed in some myoblasts in the proximal myogenic region. In older limbs expression is maintained in the myotubules. Down-regulated by mitogens. Cleaved, during apoptosis, on a specific aspartic residue by caspases. Phosphorylated on serine residues during the G0-G1 transition phase. Belongs to the GAS2 family. It is uncertain whether Met-1 or Met-2 is the initiator. initiation of primordial ovarian follicle growth antral ovarian follicle growth cytoplasm cytoskeleton apoptotic process cell cycle cell cycle arrest microtubule binding regulation of cell shape regulation of Notch signaling pathway membrane ovulation basement membrane organization uc291qic.1 uc291qic.2 
ENSMUST00000051934.7 Gskip ENSMUST00000051934.7 GSK3B interacting protein (from RefSeq NM_178613.3) ENSMUST00000051934.1 ENSMUST00000051934.2 ENSMUST00000051934.3 ENSMUST00000051934.4 ENSMUST00000051934.5 ENSMUST00000051934.6 GSKIP_MOUSE Gskip NM_178613 Q8BGR8 Q8CDW3 Q8K2G9 uc007oys.1 uc007oys.2 uc007oys.3 uc007oys.4 A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta- catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (PubMed:26582204). Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation of GSK3B leading to GSK3B inactivation; recruits DNM1L through GSK3B for PKA-mediated phosphorylation of DNM1L; promotes beta- catenin degradation through GSK3B-induced phosphorylation of beta- catenin; stabilizes beta-catenin and enhances Wnt-induced signaling through PKA-induced phosphorylation of beta-catenin. Interacts with GSK3B; induces GSK3B-mediated phosphorylation of GSKIP and inhibits GSK3B kinase activity. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGR8-1; Sequence=Displayed; Name=2; IsoId=Q8BGR8-2; Sequence=VSP_008199; Phosphorylated by GSK3B. Knockout Gskip mice die at birth. At 18.5 dpc, embryos are still alive but rapidly die within 5 to 30 min after casarean section. Embryos obtained at 18.5 dpc are cyanotic, suffer from respiratory distress, and fail to initiate breathing properly. Belongs to the GSKIP family. protein kinase inhibitor activity nucleus cytoplasm negative regulation of protein kinase activity intrinsic apoptotic signaling pathway in response to oxidative stress protein kinase binding regulation of Wnt signaling pathway protein kinase A regulatory subunit binding perinuclear region of cytoplasm protein kinase A binding regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway uc007oys.1 uc007oys.2 uc007oys.3 uc007oys.4 
ENSMUST00000051937.9 Rasl11b ENSMUST00000051937.9 RAS-like, family 11, member B (from RefSeq NM_026878.1) ENSMUST00000051937.1 ENSMUST00000051937.2 ENSMUST00000051937.3 ENSMUST00000051937.4 ENSMUST00000051937.5 ENSMUST00000051937.6 ENSMUST00000051937.7 ENSMUST00000051937.8 NM_026878 Q922H7 Q9D0S0 RSLBB_MOUSE Rasl11b uc008xtj.1 uc008xtj.2 uc008xtj.3 Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q922H7-1; Sequence=Displayed; Name=2 ; IsoId=Q922H7-2; Sequence=VSP_052585, VSP_052586; Belongs to the small GTPase superfamily. Ras family. nucleotide binding GTPase activity transforming growth factor beta receptor binding protein binding GTP binding signal transduction membrane negative regulation of transforming growth factor beta receptor signaling pathway uc008xtj.1 uc008xtj.2 uc008xtj.3 
ENSMUST00000051950.14 Atxn2 ENSMUST00000051950.14 ataxin 2, transcript variant 1 (from RefSeq NM_009125.3) Atxn2 E9QM77 E9QM77_MOUSE ENSMUST00000051950.1 ENSMUST00000051950.10 ENSMUST00000051950.11 ENSMUST00000051950.12 ENSMUST00000051950.13 ENSMUST00000051950.2 ENSMUST00000051950.3 ENSMUST00000051950.4 ENSMUST00000051950.5 ENSMUST00000051950.6 ENSMUST00000051950.7 ENSMUST00000051950.8 ENSMUST00000051950.9 NM_009125 uc008zke.1 uc008zke.2 Belongs to the ataxin-2 family. negative regulation of receptor internalization epidermal growth factor receptor binding cytoplasm Golgi apparatus trans-Golgi network cytosol polysome protein C-terminus binding cytoplasmic stress granule cytoplasmic mRNA processing body assembly stress granule assembly perinuclear region of cytoplasm ribonucleoprotein complex uc008zke.1 uc008zke.2 
ENSMUST00000051955.9 Rps23 ENSMUST00000051955.9 ribosomal protein S23 (from RefSeq NM_024175.3) ENSMUST00000051955.1 ENSMUST00000051955.2 ENSMUST00000051955.3 ENSMUST00000051955.4 ENSMUST00000051955.5 ENSMUST00000051955.6 ENSMUST00000051955.7 ENSMUST00000051955.8 NM_024175 P39028 P62267 Q542K7 RS23_MOUSE uc007rjq.1 uc007rjq.2 uc007rjq.3 uc007rjq.4 Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:36517592). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:36517592). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:36517592). Plays an important role in translational accuracy (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Component of the 40S small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Cytoplasm, cytosol Cytoplasm Rough endoplasmic reticulum Nucleus, nucleolus Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). Hydroxylation at Pro-62 affects translation termination efficiency. Belongs to the universal ribosomal protein uS12 family. cytoplasmic translation structural constituent of ribosome cytoplasm endoplasmic reticulum rough endoplasmic reticulum cytosol ribosome translation small ribosomal subunit cytosolic small ribosomal subunit stress granule assembly polysomal ribosome synapse maintenance of translational fidelity uc007rjq.1 uc007rjq.2 uc007rjq.3 uc007rjq.4 
ENSMUST00000051965.5 Defb11 ENSMUST00000051965.5 defensin beta 11 (from RefSeq NM_139221.3) DFB11_MOUSE ENSMUST00000051965.1 ENSMUST00000051965.2 ENSMUST00000051965.3 ENSMUST00000051965.4 NM_139221 Q499L3 Q8R2I7 uc009lcd.1 uc009lcd.2 uc009lcd.3 uc009lcd.4 Has antibacterial activity. Secreted Expressed in both adult and neonate brain, and very weakly in kidneys, epididymis, and testis. Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium uc009lcd.1 uc009lcd.2 uc009lcd.3 uc009lcd.4 
ENSMUST00000051985.7 Gm15421 ENSMUST00000051985.7 Gm15421 (from geneSymbol) AK166537 ENSMUST00000051985.1 ENSMUST00000051985.2 ENSMUST00000051985.3 ENSMUST00000051985.4 ENSMUST00000051985.5 ENSMUST00000051985.6 uc290tmn.1 uc290tmn.2 uc290tmn.1 uc290tmn.2 
ENSMUST00000051995.14 Jak3 ENSMUST00000051995.14 Janus kinase 3, transcript variant 1 (from RefSeq NM_010589.6) A0A0R4J0R7 A0A0R4J0R7_MOUSE ENSMUST00000051995.1 ENSMUST00000051995.10 ENSMUST00000051995.11 ENSMUST00000051995.12 ENSMUST00000051995.13 ENSMUST00000051995.2 ENSMUST00000051995.3 ENSMUST00000051995.4 ENSMUST00000051995.5 ENSMUST00000051995.6 ENSMUST00000051995.7 ENSMUST00000051995.8 ENSMUST00000051995.9 Jak3 NM_010589 uc009mem.1 uc009mem.2 uc009mem.3 uc009mem.4 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Cytoplasm Endomembrane system ; Peripheral membrane protein Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity ATP binding cytoskeleton protein phosphorylation membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation protein phosphatase binding intracellular signal transduction interleukin-4-mediated signaling pathway response to interleukin-4 uc009mem.1 uc009mem.2 uc009mem.3 uc009mem.4 
ENSMUST00000052011.15 Tle4 ENSMUST00000052011.15 transducin-like enhancer of split 4, transcript variant 2 (from RefSeq NM_011600.4) ENSMUST00000052011.1 ENSMUST00000052011.10 ENSMUST00000052011.11 ENSMUST00000052011.12 ENSMUST00000052011.13 ENSMUST00000052011.14 ENSMUST00000052011.2 ENSMUST00000052011.3 ENSMUST00000052011.4 ENSMUST00000052011.5 ENSMUST00000052011.6 ENSMUST00000052011.7 ENSMUST00000052011.8 ENSMUST00000052011.9 Grg4 NM_011600 Q62441 Q9JKQ9 TLE4_MOUSE uc008gwk.1 uc008gwk.2 uc008gwk.3 uc008gwk.4 uc008gwk.5 Transcriptional corepressor that binds to a number of transcription factors (PubMed:21317240). Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling (PubMed:10811620). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto- repression (PubMed:12050133). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (PubMed:23371388). Homooligomer and heterooligomer with other family members. Interacts with PAX5 (PubMed:10811620). Interacts with LEF1, TCF7, TCF7L1 and TCF7L2 (PubMed:11266540). Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression (PubMed:21317240). Interacts with SIX3 and SIX6 (PubMed:12050133). Interacts with PAX2 (By similarity). Interacts with TLE1 (PubMed:16314515). Q62441; Q62233: Six3; NbExp=2; IntAct=EBI-2297871, EBI-2297327; Nucleus Expressed in bone marrow-derived macrophages. WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N- terminal Q domain and the C-terminal WD-repeat domain. Phosphorylated. PAX5 binding increases phosphorylation. Ubiquitinated by XIAP/BIRC4. Belongs to the WD repeat Groucho/TLE family. It is uncertain whether Met-1 or Met-8 is the initiator. Sequence=AAF43203.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding chromatin binding transcription corepressor activity protein binding nucleus transcription factor complex regulation of transcription, DNA-templated Wnt signaling pathway negative regulation of transcription, DNA-templated repressing transcription factor binding negative regulation of canonical Wnt signaling pathway cellular response to leukemia inhibitory factor beta-catenin-TCF complex uc008gwk.1 uc008gwk.2 uc008gwk.3 uc008gwk.4 uc008gwk.5 
ENSMUST00000052012.14 Phka1 ENSMUST00000052012.14 phosphorylase kinase alpha 1, transcript variant 1 (from RefSeq NM_008832.2) A2AI90 ENSMUST00000052012.1 ENSMUST00000052012.10 ENSMUST00000052012.11 ENSMUST00000052012.12 ENSMUST00000052012.13 ENSMUST00000052012.2 ENSMUST00000052012.3 ENSMUST00000052012.4 ENSMUST00000052012.5 ENSMUST00000052012.6 ENSMUST00000052012.7 ENSMUST00000052012.8 ENSMUST00000052012.9 KPB1_MOUSE NM_008832 P18826 uc009tyr.1 uc009tyr.2 Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. By phosphorylation of various serine residues and by calcium. Glycan biosynthesis; glycogen metabolism. Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. Cell membrane ; Lipid-anchor ; Cytoplasmic side Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=ABC; IsoId=P18826-1; Sequence=Displayed; Name=2; Synonyms=AC; IsoId=P18826-2; Sequence=VSP_004698; Both isoforms are expressed in muscle. Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated. Note=Defects in Phka1 are the cause of phosphorylase kinase deficiency in I-strain mice. Belongs to the phosphorylase b kinase regulatory chain family. catalytic activity calmodulin binding plasma membrane phosphorylase kinase complex carbohydrate metabolic process glycogen metabolic process membrane protein autophosphorylation phosphorylase kinase activity uc009tyr.1 uc009tyr.2 
ENSMUST00000052027.9 Pramel19 ENSMUST00000052027.9 PRAME like 19 (from RefSeq NM_001085516.1) ENSMUST00000052027.1 ENSMUST00000052027.2 ENSMUST00000052027.3 ENSMUST00000052027.4 ENSMUST00000052027.5 ENSMUST00000052027.6 ENSMUST00000052027.7 ENSMUST00000052027.8 L7MTS5 L7MTS5_MOUSE NM_001085516 Pramel19 uc008twf.1 uc008twf.2 uc008twf.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008twf.1 uc008twf.2 uc008twf.3 
ENSMUST00000052029.10 Ppip5k1 ENSMUST00000052029.10 diphosphoinositol pentakisphosphate kinase 1, transcript variant 7 (from RefSeq NM_178795.5) A2ARP1 A2ARP2 A2ARP3 A2ARP4 ENSMUST00000052029.1 ENSMUST00000052029.2 ENSMUST00000052029.3 ENSMUST00000052029.4 ENSMUST00000052029.5 ENSMUST00000052029.6 ENSMUST00000052029.7 ENSMUST00000052029.8 ENSMUST00000052029.9 Hisppd2a Kiaa0377 NM_178795 Ppip5k1 Q6P1C8 Q7TSP1 Q80U21 Q8BL16 Q8BUN6 Q8BVG9 VIP1_MOUSE Vip1 uc008lym.1 uc008lym.2 uc008lym.3 Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. Reaction=1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo- inositol 2,3,4,5,6-pentakisphosphate + ADP; Xref=Rhea:RHEA:37459, ChEBI:CHEBI:30616, ChEBI:CHEBI:58130, ChEBI:CHEBI:74946, ChEBI:CHEBI:456216; EC=2.7.4.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37460; Evidence=; Reaction=5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP; Xref=Rhea:RHEA:10276, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58628, ChEBI:CHEBI:77983, ChEBI:CHEBI:456216; EC=2.7.4.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10277; Evidence=; Cytoplasm, cytosol Cell membrane Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=A2ARP1-1; Sequence=Displayed; Name=2; IsoId=A2ARP1-2; Sequence=VSP_030631; Name=3; IsoId=A2ARP1-3; Sequence=VSP_030634; Name=4; IsoId=A2ARP1-5; Sequence=VSP_030625, VSP_030626; Name=5; IsoId=A2ARP1-6; Sequence=VSP_030627, VSP_030628; Name=6; IsoId=A2ARP1-7; Sequence=VSP_030629, VSP_030630; The C-terminal acid phosphatase-like domain binds PtdIns(3,4,5)P3 and InsP6. Despite its similarity with the phosphatase domain of histidine acid phosphatases, it has no phosphatase activity. Belongs to the histidine acid phosphatase family. VIP1 subfamily. Sequence=BAC32838.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAC37198.1; Type=Frameshift; Evidence=; Sequence=BAC65546.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding inositol-1,3,4,5,6-pentakisphosphate kinase activity inositol hexakisphosphate kinase activity inositol heptakisphosphate kinase activity inositol hexakisphosphate 5-kinase activity ATP binding nucleoplasm cytoplasm cytosol plasma membrane inositol metabolic process membrane kinase activity phosphorylation transferase activity inositol phosphate biosynthetic process diphosphoinositol-pentakisphosphate kinase activity inositol hexakisphosphate 1-kinase activity inositol hexakisphosphate 3-kinase activity uc008lym.1 uc008lym.2 uc008lym.3 
ENSMUST00000052060.7 Masp2 ENSMUST00000052060.7 MBL associated serine protease 2, transcript variant 1 (from RefSeq NM_001003893.2) B1ARY2 B1ARY3 ENSMUST00000052060.1 ENSMUST00000052060.2 ENSMUST00000052060.3 ENSMUST00000052060.4 ENSMUST00000052060.5 ENSMUST00000052060.6 MASP2_MOUSE NM_001003893 Q91WP0 Q9QXA4 Q9QXD2 Q9QXD5 Q9Z338 uc008vuy.1 uc008vuy.2 uc008vuy.3 uc008vuy.4 Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase (By similarity). Reaction=Selective cleavage after Arg-223 in complement component C2 (- Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).; EC=3.4.21.104; Homodimer; disulfide-linked. Binds MBL2. Isoform 2 binds to MASP1. Binds SERPING1 (By similarity). Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91WP0-1; Sequence=Displayed; Name=2; Synonyms=MAp19; IsoId=Q91WP0-2; Sequence=VSP_014636, VSP_014637; Plasma. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Dimerization and MBL2 binding requires calcium ions. Belongs to the peptidase S1 family. complement component C4b binding complement activation, lectin pathway immune system process serine-type endopeptidase activity calcium ion binding protein binding extracellular region extracellular space proteolysis complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity innate immune response metal ion binding calcium-dependent protein binding uc008vuy.1 uc008vuy.2 uc008vuy.3 uc008vuy.4 
ENSMUST00000052068.11 Rbp1 ENSMUST00000052068.11 retinol binding protein 1, cellular (from RefSeq NM_011254.5) ENSMUST00000052068.1 ENSMUST00000052068.10 ENSMUST00000052068.2 ENSMUST00000052068.3 ENSMUST00000052068.4 ENSMUST00000052068.5 ENSMUST00000052068.6 ENSMUST00000052068.7 ENSMUST00000052068.8 ENSMUST00000052068.9 NM_011254 Q58EU7 Q58EU7_MOUSE Rbp1 uc009rdj.1 uc009rdj.2 uc009rdj.3 uc009rdj.4 Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. retinoic acid biosynthetic process nucleoplasm cytosol vitamin A metabolic process lipid binding retinol binding retinol metabolic process cell body uc009rdj.1 uc009rdj.2 uc009rdj.3 uc009rdj.4 
ENSMUST00000052072.8 Tmem221 ENSMUST00000052072.8 transmembrane protein 221 (from RefSeq NM_001100462.1) B2RWI9 ENSMUST00000052072.1 ENSMUST00000052072.2 ENSMUST00000052072.3 ENSMUST00000052072.4 ENSMUST00000052072.5 ENSMUST00000052072.6 ENSMUST00000052072.7 NM_001100462 Q8K071 TM221_MOUSE uc012gft.1 uc012gft.2 uc012gft.3 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc012gft.1 uc012gft.2 uc012gft.3 
ENSMUST00000052079.8 Pram1 ENSMUST00000052079.8 PML-RAR alpha-regulated adaptor molecule 1, transcript variant 1 (from RefSeq NM_001002842.2) E9QL42 ENSMUST00000052079.1 ENSMUST00000052079.2 ENSMUST00000052079.3 ENSMUST00000052079.4 ENSMUST00000052079.5 ENSMUST00000052079.6 ENSMUST00000052079.7 NM_001002842 PRAM_MOUSE Q6BCL1 uc008bzb.1 uc008bzb.2 uc008bzb.3 May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P. Interacts with SKAP2, LCP2 and DBNL. May interact with LYN (By similarity). Interacts with NEK6 (By similarity). Expressed in bone marrow and mature neutrophils. Weakly expressed in macrophages and mast cells. The SH3 domain binds to PtdIns(4)P. May be phosphorylated on tyrosines. Mice are healthy and do not display any obvious abnormality. They have normal hematopoietic differentiation. plasma membrane integrin-mediated signaling pathway lipid binding protein kinase binding macromolecular complex regulation of neutrophil degranulation T cell receptor signaling pathway protein localization to plasma membrane uc008bzb.1 uc008bzb.2 uc008bzb.3 
ENSMUST00000052107.5 Zswim3 ENSMUST00000052107.5 zinc finger SWIM-type containing 3 (from RefSeq NM_178375.2) ENSMUST00000052107.1 ENSMUST00000052107.2 ENSMUST00000052107.3 ENSMUST00000052107.4 NM_178375 Q8CFL8 ZSWM3_MOUSE uc008nwh.1 uc008nwh.2 uc008nwh.3 cellular_component biological_process zinc ion binding metal ion binding uc008nwh.1 uc008nwh.2 uc008nwh.3 
ENSMUST00000052113.12 St7 ENSMUST00000052113.12 suppression of tumorigenicity 7, transcript variant 5 (from RefSeq NM_001289626.1) ENSMUST00000052113.1 ENSMUST00000052113.10 ENSMUST00000052113.11 ENSMUST00000052113.2 ENSMUST00000052113.3 ENSMUST00000052113.4 ENSMUST00000052113.5 ENSMUST00000052113.6 ENSMUST00000052113.7 ENSMUST00000052113.8 ENSMUST00000052113.9 NM_001289626 Q3UA20 Q6Q9W2 Q6Q9W3 Q8R3T3 Q921F6 Q99M89 Q99M90 Q99M91 Q99M92 Q99M93 Q99M94 Q99M96 Q9JID7 Q9JID8 ST7_MOUSE uc009azw.1 uc009azw.2 uc009azw.3 uc009azw.4 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=9; Name=1; IsoId=Q99M96-1; Sequence=Displayed; Name=2; IsoId=Q99M96-2; Sequence=VSP_034124; Name=3; IsoId=Q99M96-3; Sequence=VSP_034123; Name=4; IsoId=Q99M96-4; Sequence=VSP_034118, VSP_034123; Name=5; IsoId=Q99M96-5; Sequence=VSP_034118; Name=6; IsoId=Q99M96-6; Sequence=VSP_034120, VSP_034121; Name=7; IsoId=Q99M96-7; Sequence=VSP_034120, VSP_034121, VSP_034123; Name=8; IsoId=Q99M96-8; Sequence=VSP_034119, VSP_034122; Name=9; IsoId=Q99M96-9; Sequence=VSP_034119, VSP_034122, VSP_034123; Belongs to the ST7 family. Sequence=AAH12719.1; Type=Erroneous initiation; Evidence=; membrane integral component of membrane uc009azw.1 uc009azw.2 uc009azw.3 uc009azw.4 
ENSMUST00000052120.14 Wdr3 ENSMUST00000052120.14 WD repeat domain 3, transcript variant 1 (from RefSeq NM_175552.5) ENSMUST00000052120.1 ENSMUST00000052120.10 ENSMUST00000052120.11 ENSMUST00000052120.12 ENSMUST00000052120.13 ENSMUST00000052120.2 ENSMUST00000052120.3 ENSMUST00000052120.4 ENSMUST00000052120.5 ENSMUST00000052120.6 ENSMUST00000052120.7 ENSMUST00000052120.8 ENSMUST00000052120.9 NM_175552 Q8BHB4 WDR3_MOUSE uc008qqo.1 uc008qqo.2 uc008qqo.3 uc008qqo.4 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus Belongs to the WD repeat WDR3/UTP12 family. nucleus nucleolus nuclear membrane small-subunit processome Pwp2p-containing subcomplex of 90S preribosome uc008qqo.1 uc008qqo.2 uc008qqo.3 uc008qqo.4 
ENSMUST00000052124.9 Nlrc4 ENSMUST00000052124.9 NLR family, CARD domain containing 4 (from RefSeq NM_001033367.3) Card12 ENSMUST00000052124.1 ENSMUST00000052124.2 ENSMUST00000052124.3 ENSMUST00000052124.4 ENSMUST00000052124.5 ENSMUST00000052124.6 ENSMUST00000052124.7 ENSMUST00000052124.8 Ipaf NLRC4_MOUSE NM_001033367 Q3TAU8 Q3UP24 uc008doc.1 uc008doc.2 uc008doc.3 Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. It senses pathogenic proteins of the type III secretion system (T3SS) and type IV secretion system (T4SS) such as flagellin and PrgJ-like rod proteins via the Naip proteins (Naip1, Naip2 or Naip5): specific Naip proteins recognize and bind pathogenic proteins, driving assembly and activation of the NLRC4 inflammasome. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri and fungal pathogen C.albicans. In intestine, the NLRC4 inflammasome is able to discriminate between commensal and pathogenic bacteria and specifically drives production of interleukin-1 beta (IL1B) in response to infection by Salmonella or P.aeruginosa. In case of L.pneumophila infection the inflammasome acts by activating caspase-7. Homooligomer; homooligomerizes following activation of Naip proteins by pathogenic proteins such as S.typhimurium (Salmonella) flagellin or PrgJ (PubMed:23765277, PubMed:26449474, PubMed:26585513, PubMed:29146805). Component of the NLRC4 inflammasome, at least composed of NLRC4, caspase-1 (CASP1) and some NAIP protein (Naip, Naip2 or Naip5) (PubMed:21874021, PubMed:21918512, PubMed:26585513). Interacts with Naip5 and Naip6; following Naip5 and Naip6 engagement by Salmonella flagellin (PubMed:21874021, PubMed:21918512, PubMed:29182158, PubMed:29146805). Interacts with Naip2; following Naip2 engagement by Salmonella PrgJ (PubMed:21874021, PubMed:21918512, PubMed:26449474). The inflammasome is a huge complex that contains multiple copies of NLRC4 and a single Naip protein chain (PubMed:26449474, PubMed:29146805). Some NLRC4 inflammasomes contain PYCARD/ASC, while some others directly contact and activate CASP1 (PubMed:21147462). Interacts with EIF2AK2/PKR (By similarity). Q3UP24; P29452: Casp1; NbExp=2; IntAct=EBI-16006652, EBI-489700; Q3UP24; Q9R016: Naip5; NbExp=18; IntAct=EBI-16006652, EBI-15944130; Q3UP24; Q3UP24: Nlrc4; NbExp=4; IntAct=EBI-16006652, EBI-16006652; Cytoplasm, cytosol Inflammasome Expressed by intestinal mononuclear phagocytes. In an autoinhibited form the C-terminal leucine-rich repeat (LRR) domain is positioned to sterically occlude one side of the NBD domain and consequently sequester NLRC4 in a monomeric state. An ADP- mediated interaction between the NBD and the WHD also contributes to the autoinhibition (PubMed:23765277). Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation is essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates Ser-533 in vitro. Mice show defects in inflammasome function in response to S.typhimurium (Salmonella) infection. Differences are however observed depending on the strain background: in a C57BL/6J strain background, no striking differences are observed compared to wild-type mice following Salmonella infection. While in a BALB/c strain background, mice are highly susceptible to orogastric but not intraperitoneal infection with Salmonella: enhanced lethality is preceded by impaired expression of endothelial adhesion molecules, lower neutrophil recruitment and poor intestinal pathogen clearance. nucleotide binding activation of innate immune response immune system process protein binding ATP binding cytoplasm cytosol apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response detection of bacterium defense response to bacterium identical protein binding protein homodimerization activity regulation of apoptotic process positive regulation of apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process innate immune response interleukin-1 beta secretion positive regulation of NF-kappaB transcription factor activity protein homooligomerization pyroptosis IPAF inflammasome complex uc008doc.1 uc008doc.2 uc008doc.3 
ENSMUST00000052125.7 Pard6b ENSMUST00000052125.7 par-6 family cell polarity regulator beta (from RefSeq NM_021409.2) A2ANX8 ENSMUST00000052125.1 ENSMUST00000052125.2 ENSMUST00000052125.3 ENSMUST00000052125.4 ENSMUST00000052125.5 ENSMUST00000052125.6 NM_021409 PAR6B_MOUSE Par6b Q8R3J8 Q9JK83 uc008oao.1 uc008oao.2 uc008oao.3 Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Interacts with PARD3. Interacts with GTP-bound forms of CDC42, RHOQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19. Interacts with ECT2 (By similarity). Interacts with PALS1. Q9JK83; P60953: CDC42; Xeno; NbExp=6; IntAct=EBI-81861, EBI-81752; Q9JK83; Q8TEW0: PARD3; Xeno; NbExp=3; IntAct=EBI-81861, EBI-81968; Cytoplasm. Cell membrane. Cell junction, tight junction. Note=Colocalizes with active form of CDC42 or RAC1 at membrane ruffles. Also localizes to tight junctions. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JK83-1; Sequence=Displayed; Name=2; IsoId=Q9JK83-2; Sequence=VSP_007460, VSP_007461; Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues. The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases. The PDZ domain mediates the interaction with PALS1. Belongs to the PAR6 family. protein kinase C binding protein binding nucleus cytoplasm cytosol plasma membrane bicellular tight junction cell cortex cell-cell junction assembly cell cycle centrosome cycle establishment or maintenance of cell polarity membrane apical plasma membrane Rho GTPase binding cell junction macromolecular complex apical part of cell cell division regulation of cellular localization macromolecular complex assembly uc008oao.1 uc008oao.2 uc008oao.3 
ENSMUST00000052126.6 Fam25a ENSMUST00000052126.6 family with sequence similarity 25, member A (from RefSeq NM_183278.3) B2RVA0 ENSMUST00000052126.1 ENSMUST00000052126.2 ENSMUST00000052126.3 ENSMUST00000052126.4 ENSMUST00000052126.5 FM25C_MOUSE Fam25c NM_183278 Q8CF02 uc007tat.1 uc007tat.2 uc007tat.3 Belongs to the FAM25 family. molecular_function cellular_component biological_process uc007tat.1 uc007tat.2 uc007tat.3 
ENSMUST00000052135.14 Rbbp6 ENSMUST00000052135.14 retinoblastoma binding protein 6, ubiquitin ligase, transcript variant 1 (from RefSeq NM_011247.3) ENSMUST00000052135.1 ENSMUST00000052135.10 ENSMUST00000052135.11 ENSMUST00000052135.12 ENSMUST00000052135.13 ENSMUST00000052135.2 ENSMUST00000052135.3 ENSMUST00000052135.4 ENSMUST00000052135.5 ENSMUST00000052135.6 ENSMUST00000052135.7 ENSMUST00000052135.8 ENSMUST00000052135.9 NM_011247 P2pr P70287 P97868 Pact Q3TTR9 Q3TUM7 Q3UMP7 Q4U217 Q7TT06 Q8BNY8 Q8R399 RBBP6_MOUSE uc009joy.1 uc009joy.2 uc009joy.3 uc009joy.4 E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation (PubMed:17470788). Regulates DNA-replication and common fragile sites (CFS) stability in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with MDM2 and YBX1 (By similarity). Interacts also with p53/TP53 and RB1. Interacts with NEK6 (By similarity). Interacts with ZBTB38 (By similarity). Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P97868-1; Sequence=Displayed; Name=2; IsoId=P97868-2; Sequence=VSP_018287; Name=3; IsoId=P97868-3; Sequence=VSP_018285, VSP_018286; Highly expressed in testis. Expressed at lower levels in brain, heart, kidney, liver, lung, skeletal muscle, spleen, thymus and tongue. Expression is reduced during terminal differentiation. Expression is induced in the G2/M phase of the cell cycle (at protein level). Contains a N-terminus DWNN domain, a zinc-finger domain and a C4C4 zinc-binding RING finger domain (By similarity). The ring finger may indeed be a U-box domain (By similarity). Phosphorylated by NEK6. Early embryonic lethality before 7.5 dpc, accompanied by accumulation of p53 and widespread apoptosis. Sequence=AAC72432.1; Type=Frameshift; Evidence=; in utero embryonic development nucleic acid binding ubiquitin-protein transferase activity nucleus chromosome nucleolus cytoplasm centrosome microtubule organizing center cytoskeleton DNA replication regulation of DNA replication mRNA processing ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus zinc ion binding protein ubiquitination nuclear speck transferase activity protein kinase binding macromolecular complex multicellular organism growth metal ion binding embryonic organ development somite development ubiquitin protein ligase activity uc009joy.1 uc009joy.2 uc009joy.3 uc009joy.4 
ENSMUST00000052138.11 Terf2ip ENSMUST00000052138.11 telomeric repeat binding factor 2, interacting protein (from RefSeq NM_020584.2) D3YWE8 ENSMUST00000052138.1 ENSMUST00000052138.10 ENSMUST00000052138.2 ENSMUST00000052138.3 ENSMUST00000052138.4 ENSMUST00000052138.5 ENSMUST00000052138.6 ENSMUST00000052138.7 ENSMUST00000052138.8 ENSMUST00000052138.9 MNCb-0448 MNCb-0628 NM_020584 Q543F4 Q8C2Y1 Q91VL8 Q9JJE8 Q9JJE9 Rap1 TE2IP_MOUSE uc012gla.1 uc012gla.2 uc012gla.3 Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology- directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF- kappa-B target genes. Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Binds to TERF2 (but not TERF1) with its C-terminus. Interacts with SLX4/BTBD12 (By similarity). Interacts with TERF2; the interaction is direct. Does not interact with TERF1. Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG. Nucleus Cytoplasm Chromosome Chromosome, telomere Note=Associates with chromosomes, both at telomeres and in extratelomeric sites (PubMed:20622869). Also exists as a cytoplasmic form, where it associates with the IKK complex (PubMed:20622870). Mice are viable and fertile. No major telomere dysfunction such as telomere fusions are observed. An increased telomere fragility and recombination due to defects in HDR are however present. Mice with conditional deletion in stratified epithelia display shorter telomeres and developed skin hyperpigmentation in adulthood. Shares a bidirectional promoter with KARS1 (PubMed:14659874). This shared promoter with an essential gene complicated the task when generating knockout mice; the problem was overcome by generating conditional knockout strategies (PubMed:20339076, PubMed:20622869). Belongs to the RAP1 family. Sequence=BAA95043.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; telomere maintenance chromosome, telomeric region nuclear telomere cap complex nuclear chromosome, telomeric region negative regulation of protein phosphorylation DNA binding protein binding nucleus nucleoplasm chromosome cytoplasm cytosol regulation of transcription, DNA-templated regulation of double-strand break repair via homologous recombination telomere maintenance via telomere lengthening nuclear body phosphatase binding Mre11 complex regulation of telomere maintenance negative regulation of telomere maintenance positive regulation of peptidyl-serine phosphorylation telomeric DNA binding positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of DNA recombination at telomere positive regulation of NF-kappaB transcription factor activity telosome protein localization to chromosome, telomeric region G-rich strand telomeric DNA binding positive regulation of NIK/NF-kappaB signaling positive regulation of protein acetylation nuclear envelope telomeric loop formation protection from non-homologous end joining at telomere uc012gla.1 uc012gla.2 uc012gla.3 
ENSMUST00000052140.3 Haspin ENSMUST00000052140.3 histone H3 associated protein kinase (from RefSeq NM_010353.2) A0A0R4J0P2 A0A0R4J0P2_MOUSE ENSMUST00000052140.1 ENSMUST00000052140.2 Gsg2 Haspin NM_010353 uc007jzz.1 uc007jzz.2 uc007jzz.3 uc007jzz.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; protein kinase activity ATP binding nucleus centrosome spindle protein phosphorylation mitotic sister chromatid cohesion intracellular signal transduction protein localization to chromosome, centromeric region histone kinase activity (H3-T3 specific) histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore uc007jzz.1 uc007jzz.2 uc007jzz.3 uc007jzz.4 
ENSMUST00000052152.3 Or51v14 ENSMUST00000052152.3 olfactory receptor family 51 subfamily V member 14 (from RefSeq NM_146812.2) E9PZ66 E9PZ66_MOUSE ENSMUST00000052152.1 ENSMUST00000052152.2 NM_146812 Olfr620 Or51v14 uc291trf.1 uc291trf.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC106798.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291trf.1 uc291trf.2 
ENSMUST00000052164.4 Npy4r ENSMUST00000052164.4 neuropeptide Y receptor Y4 (from RefSeq NM_008919.4) ENSMUST00000052164.1 ENSMUST00000052164.2 ENSMUST00000052164.3 NM_008919 NPY4R_MOUSE Ppyr1 Q3UN46 Q61041 uc007tak.1 uc007tak.2 uc007tak.3 uc007tak.4 G protein-coupled receptor for PPY/pancreatic polypeptide/PP that is negatively coupled to cAMP (PubMed:8641440). Has much lower affinity for the NPY/neuropeptide Y and PYY/peptide YY (PubMed:8641440). Cell membrane ; Multi-pass membrane protein Heart, detected in small intestine. Belongs to the G-protein coupled receptor 1 family. peptide YY receptor activity pancreatic polypeptide receptor activity G-protein coupled receptor activity neuropeptide Y receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway membrane integral component of membrane peptide binding uc007tak.1 uc007tak.2 uc007tak.3 uc007tak.4 
ENSMUST00000052168.6 Otud1 ENSMUST00000052168.6 OTU domain containing 1 (from RefSeq NM_027715.2) A2ATK4 ENSMUST00000052168.1 ENSMUST00000052168.2 ENSMUST00000052168.3 ENSMUST00000052168.4 ENSMUST00000052168.5 NM_027715 OTUD1_MOUSE Q9CUB6 uc008imj.1 uc008imj.2 uc008imj.3 uc008imj.4 Deubiquitinating enzyme that specifically hydrolyzes 'Lys- 63'-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; The UIM repeat increases the specificity and efficiency of the enzyme toward 'Lys-63'-linked polyubiquitin. Specificity is not given by the S1' ubiquitin-binding site within the OTU domain (composed of the Cys-, His- and Variable-loops). Sequence=BAB30530.1; Type=Frameshift; Evidence=; thiol-dependent ubiquitin-specific protease activity cellular_component proteolysis peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity protein K63-linked deubiquitination uc008imj.1 uc008imj.2 uc008imj.3 uc008imj.4 
ENSMUST00000052172.7 Cxcr4 ENSMUST00000052172.7 C-X-C motif chemokine receptor 4, transcript variant 1 (from RefSeq NM_009911.4) A0A0R4J0N8 A0A0R4J0N8_MOUSE Cxcr4 ENSMUST00000052172.1 ENSMUST00000052172.2 ENSMUST00000052172.3 ENSMUST00000052172.4 ENSMUST00000052172.5 ENSMUST00000052172.6 NM_009911 uc007clt.1 uc007clt.2 uc007clt.3 Cell junction Cell membrane ; Multi-pass membrane protein Early endosome Endosome Late endosome Lysosome Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. response to hypoxia neuron migration epithelial cell development actin binding G-protein coupled receptor activity chemokine receptor activity nucleus cytoplasm lysosome endosome early endosome late endosome plasma membrane chemotaxis signal transduction G-protein coupled receptor signaling pathway neuron recognition drug binding cell surface response to activity membrane integral component of membrane cell migration C-X-C chemokine receptor activity calcium-mediated signaling cytokine binding C-C chemokine binding neurogenesis telencephalon cell migration regulation of cell adhesion positive regulation of cell migration cell leading edge cytoplasmic vesicle ubiquitin protein ligase binding myosin light chain binding macromolecular complex positive regulation of vascular wound healing cellular response to drug C-X-C motif chemokine 12 receptor activity CXCL12-activated CXCR4 signaling pathway identical protein binding regulation of programmed cell death ubiquitin binding response to morphine endothelial cell differentiation positive regulation of neurogenesis regulation of viral process regulation of chemotaxis positive regulation of chemotaxis detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain regulation of calcium ion transport cardiac muscle contraction endothelial tube morphogenesis cellular response to cytokine stimulus positive regulation of dendrite extension positive regulation of mesenchymal stem cell migration response to ultrasound positive regulation of macrophage migration inhibitory factor signaling pathway uc007clt.1 uc007clt.2 uc007clt.3 
ENSMUST00000052174.3 Pigz ENSMUST00000052174.3 phosphatidylinositol glycan anchor biosynthesis, class Z (from RefSeq NM_172822.3) ENSMUST00000052174.1 ENSMUST00000052174.2 NM_172822 PIGZ_MOUSE Q149K0 Q8BTP0 uc007yxx.1 uc007yxx.2 uc007yxx.3 Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers a fourth mannose to some trimannosyl- GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues (By similarity). Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the glycosyltransferase 22 family. PIGZ subfamily. alpha-1,2-mannosyltransferase activity mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups mannosylation uc007yxx.1 uc007yxx.2 uc007yxx.3 
ENSMUST00000052179.8 Pcdhb20 ENSMUST00000052179.8 protocadherin beta 20 (from RefSeq NM_053145.3) ENSMUST00000052179.1 ENSMUST00000052179.2 ENSMUST00000052179.3 ENSMUST00000052179.4 ENSMUST00000052179.5 ENSMUST00000052179.6 ENSMUST00000052179.7 NM_053145 Pcdhb20 Q91XZ9 Q91XZ9_MOUSE uc008eqf.1 uc008eqf.2 uc008eqf.3 uc008eqf.4 uc008eqf.5 molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eqf.1 uc008eqf.2 uc008eqf.3 uc008eqf.4 uc008eqf.5 
ENSMUST00000052183.7 Snip1 ENSMUST00000052183.7 Smad nuclear interacting protein 1, transcript variant 1 (from RefSeq NM_175246.5) ENSMUST00000052183.1 ENSMUST00000052183.2 ENSMUST00000052183.3 ENSMUST00000052183.4 ENSMUST00000052183.5 ENSMUST00000052183.6 NM_175246 Q3V106 Q8BIZ4 Q8BIZ6 SNIP1_MOUSE uc008urq.1 uc008urq.2 uc008urq.3 uc008urq.4 Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Down- regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Component of activated spliceosome complexes. Binds SMAD4 and CREBBP/EP300. Component of the minor spliceosome, which splices U12- type introns (By similarity). Binds the SMAD1/OAZ1/PSMB4 complex. Interacts with DROSHA and SMARCA4. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Nucleus Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex. mRNA splicing, via spliceosome mRNA binding protein binding nucleus nucleoplasm spliceosomal complex cytosol regulation of transcription from RNA polymerase II promoter mRNA processing I-kappaB kinase/NF-kappaB signaling RNA splicing gene silencing by RNA production of miRNAs involved in gene silencing by miRNA U2-type precatalytic spliceosome uc008urq.1 uc008urq.2 uc008urq.3 uc008urq.4 
ENSMUST00000052185.5 B3galt6 ENSMUST00000052185.5 UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6 (from RefSeq NM_080445.4) B3GT6_MOUSE ENSMUST00000052185.1 ENSMUST00000052185.2 ENSMUST00000052185.3 ENSMUST00000052185.4 NM_080445 Q8CC93 Q91Z92 uc008wfq.1 uc008wfq.2 uc008wfq.3 Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues. Reaction=3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl- [protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->3)- beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:11780, Rhea:RHEA-COMP:12570, Rhea:RHEA- COMP:12571, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:132088, ChEBI:CHEBI:132090; EC=2.4.1.134; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11781; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 31 family. Name=Functional Glycomics Gateway - GTase; Note=b3GalT6; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_459"; Golgi membrane endoplasmic reticulum Golgi apparatus Golgi medial cisterna glycosaminoglycan biosynthetic process protein glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity heparan sulfate proteoglycan biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups chondroitin sulfate biosynthetic process UDP-galactosyltransferase activity galactosylxylosylprotein 3-beta-galactosyltransferase activity uc008wfq.1 uc008wfq.2 uc008wfq.3 
ENSMUST00000052189.5 B230317F23Rik ENSMUST00000052189.5 B230317F23Rik (from geneSymbol) ENSMUST00000052189.1 ENSMUST00000052189.2 ENSMUST00000052189.3 ENSMUST00000052189.4 uc292ade.1 uc292ade.2 uc292ade.3 uc292ade.1 uc292ade.2 uc292ade.3 
ENSMUST00000052201.9 Mis18bp1 ENSMUST00000052201.9 MIS18 binding protein 1, transcript variant 4 (from RefSeq NR_185036.1) ENSMUST00000052201.1 ENSMUST00000052201.2 ENSMUST00000052201.3 ENSMUST00000052201.4 ENSMUST00000052201.5 ENSMUST00000052201.6 ENSMUST00000052201.7 ENSMUST00000052201.8 Kiaa1903 Knl2 M18BP_MOUSE M18bp1 NR_185036 Q571G6 Q80WQ8 Q8BPR7 Q8CBB5 Q8CG92 uc007nrg.1 uc007nrg.2 uc007nrg.3 uc007nrg.4 Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. Interacts with SP1. Interacts with MIS18A. Identified in a complex containing MIS18A, OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4. Interacts with KAT7/HBO1 (By similarity). Interacts (via N-terminus) with FLNA (via N-terminus) (PubMed:21228480). Nucleus Chromosome, centromere Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80WQ8-1; Sequence=Displayed; Name=2; IsoId=Q80WQ8-2; Sequence=VSP_037732, VSP_037733; Name=3; IsoId=Q80WQ8-3; Sequence=VSP_037731; chromosome, centromeric region condensed nuclear chromosome kinetochore DNA binding protein binding nucleus chromosome cell cycle cell division uc007nrg.1 uc007nrg.2 uc007nrg.3 uc007nrg.4 
ENSMUST00000052204.6 Nipa1 ENSMUST00000052204.6 non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human) (from RefSeq NM_153578.3) ENSMUST00000052204.1 ENSMUST00000052204.2 ENSMUST00000052204.3 ENSMUST00000052204.4 ENSMUST00000052204.5 NIPA1_MOUSE NM_153578 Q8BHK1 Spg6 uc009hdu.1 uc009hdu.2 uc009hdu.3 Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Zn(2+) and Co(2+) but to a much less extent than Mg(2+). Reaction=Mg(2+)(in) = Mg(2+)(out); Xref=Rhea:RHEA:29827, ChEBI:CHEBI:18420; Evidence=; Kinetic parameters: KM=0.69 mM for magnesium ions ; Homodimer. Cell membrane ; Multi-pass membrane protein Early endosome Note=Recruited to the cell membrane in response to low extracellular magnesium. Widely expressed. Predominantly expressed in neuronal tissues. Brain, heart, kidney, liver and colon (at protein level). Up-regulated by low magnesium ion levels. Belongs to the NIPA family. endosome early endosome plasma membrane ion transport magnesium ion transmembrane transporter activity magnesium ion transport membrane integral component of membrane magnesium ion transmembrane transport uc009hdu.1 uc009hdu.2 uc009hdu.3 
ENSMUST00000052209.9 Cbfb ENSMUST00000052209.9 core binding factor beta, transcript variant 1 (from RefSeq NM_022309.4) ENSMUST00000052209.1 ENSMUST00000052209.2 ENSMUST00000052209.3 ENSMUST00000052209.4 ENSMUST00000052209.5 ENSMUST00000052209.6 ENSMUST00000052209.7 ENSMUST00000052209.8 NM_022309 PEBB_MOUSE Pebp2b Pebpb2 Q08024 Q08025 Q62050 Q62051 Q8C282 Q8CGD5 uc009nbp.1 uc009nbp.2 uc009nbp.3 uc009nbp.4 Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'- TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T- cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). Heterodimer with RUNX1, RUNX2 and RUNX3 (Probable). Interacts with COPRS. Found in a complex with PRMT5 and RUNX1 (PubMed:22193545). Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q08024-1; Sequence=Displayed; Name=2; IsoId=Q08024-2; Sequence=VSP_004360; Name=3; IsoId=Q08024-3; Sequence=VSP_004359; Name=4; IsoId=Q08024-4; Sequence=VSP_004358; Expressed in all tissues tested. Highest level in thymus, but also abundantly expressed in muscle, lung and brain. [Isoform 2]: Major isoform. [Isoform 3]: Does not dimerize with the alpha subunit. [Isoform 4]: Does not dimerize with the alpha subunit. Belongs to the CBF-beta family. negative regulation of transcription from RNA polymerase II promoter protein polyubiquitination ossification osteoblast differentiation DNA binding transcription cofactor activity transcription coactivator activity protein binding nucleus nucleoplasm core-binding factor complex lymphocyte differentiation myeloid cell differentiation macromolecular complex negative regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of CD8-positive, alpha-beta T cell differentiation positive regulation of transcription from RNA polymerase II promoter cell maturation definitive hemopoiesis sequence-specific DNA binding uc009nbp.1 uc009nbp.2 uc009nbp.3 uc009nbp.4 
ENSMUST00000052211.4 Znrf4 ENSMUST00000052211.4 zinc and ring finger 4 (from RefSeq NM_011483.2) ENSMUST00000052211.1 ENSMUST00000052211.2 ENSMUST00000052211.3 NM_011483 Q9DAH2 Q9WTN2 Spzn ZNRF4_MOUSE Znrf4 uc008dce.1 uc008dce.2 uc008dce.3 E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2 (By similarity). Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (By similarity). Could have a role in spermatogenesis (PubMed:10191088). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with CANX. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Expressed exclusively in spermatids (at protein level). Detected in the testis from the postpubertal stage (23 days) onwards, with highest expression at 29 days. The RING-type zinc finger is involved in CANX ubiquitination and degradation, but is not required for interaction with CANX. cytoplasm lysosomal membrane endoplasmic reticulum endoplasmic reticulum membrane ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination transferase activity metal ion binding ubiquitin protein ligase activity uc008dce.1 uc008dce.2 uc008dce.3 
ENSMUST00000052224.7 Psapl1 ENSMUST00000052224.7 prosaposin-like 1 (from RefSeq NM_175249.3) ENSMUST00000052224.1 ENSMUST00000052224.2 ENSMUST00000052224.3 ENSMUST00000052224.4 ENSMUST00000052224.5 ENSMUST00000052224.6 NM_175249 Q8BJV5 Q8C1C1 Q8C1N0 SAPL1_MOUSE uc008xem.1 uc008xem.2 uc008xem.3 uc008xem.4 May activate the lysosomal degradation of sphingolipids. Secreted Sequence=BAC25258.1; Type=Frameshift; Evidence=; Sequence=BAC25961.1; Type=Erroneous initiation; Evidence=; Sequence=BAC37363.1; Type=Frameshift; Evidence=; extracellular region extracellular space lysosome cytosol lipid metabolic process sphingolipid metabolic process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway regulation of lipid metabolic process prostate gland growth epithelial cell differentiation involved in prostate gland development uc008xem.1 uc008xem.2 uc008xem.3 uc008xem.4 
ENSMUST00000052236.13 Fbxo10 ENSMUST00000052236.13 F-box protein 10, transcript variant 6 (from RefSeq NM_001378823.1) A2ANI6 ENSMUST00000052236.1 ENSMUST00000052236.10 ENSMUST00000052236.11 ENSMUST00000052236.12 ENSMUST00000052236.2 ENSMUST00000052236.3 ENSMUST00000052236.4 ENSMUST00000052236.5 ENSMUST00000052236.6 ENSMUST00000052236.7 ENSMUST00000052236.8 ENSMUST00000052236.9 FBX10_MOUSE Gm634 NM_001378823 Q6AXG0 Q7TQF2 Q7TQM0 uc008ssf.1 uc008ssf.2 uc008ssf.3 uc008ssf.4 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Targets also the receptor for advanced glycation end products RAGE for ubiquitination and subsequent lysosomal degradation. Directly controls HGAL/GCSAM ubiquitination and degradation and thereby decreases BCR signaling. Protein modification; protein ubiquitination. Component of the SCF(FBXO10) complex consisting of CUL1, SKP1 and FBXO10. Interacts with BCL2. Interacts with PRDM1. Cytoplasm Particularly highly expressed in B-cells. FBXO10 deletion has no detectable effect on B- cells in bone marrow or spleen. Similarly, it has no detectable effect on T-cell thymic development or T-cell splenic maturation. Sequence=AAH54731.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; ubiquitin-protein transferase activity cytoplasm ubiquitin-dependent protein catabolic process apoptotic process protein ubiquitination regulation of apoptotic process uc008ssf.1 uc008ssf.2 uc008ssf.3 uc008ssf.4 
ENSMUST00000052248.8 Eef1g ENSMUST00000052248.8 eukaryotic translation elongation factor 1 gamma (from RefSeq NM_026007.4) EF1G_MOUSE ENSMUST00000052248.1 ENSMUST00000052248.2 ENSMUST00000052248.3 ENSMUST00000052248.4 ENSMUST00000052248.5 ENSMUST00000052248.6 ENSMUST00000052248.7 NM_026007 Q920C5 Q9CRT5 Q9CSU3 Q9D004 Q9D8N0 uc008goi.1 uc008goi.2 uc008goi.3 Probably plays a role in anchoring the complex to other cellular components. EF-1 is composed of four subunits: alpha, beta, delta, and gamma. translation elongation factor activity nucleus cytoplasm endoplasmic reticulum translation translational elongation response to virus uc008goi.1 uc008goi.2 uc008goi.3 
ENSMUST00000052249.7 Mrps27 ENSMUST00000052249.7 mitochondrial ribosomal protein S27 (from RefSeq NM_173757.3) E9QKZ5 ENSMUST00000052249.1 ENSMUST00000052249.2 ENSMUST00000052249.3 ENSMUST00000052249.4 ENSMUST00000052249.5 ENSMUST00000052249.6 Mrps27 NM_173757 Q8BK72 RT27_MOUSE uc007rpn.1 uc007rpn.2 uc007rpn.3 RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Overexpressed in hepatocellular carcinoma tissues compared with adjacent non-tumoral liver tissues. Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins (By similarity). Interacts with NOA1 (By similarity). Interacts with MIEF1 upstream open reading frame protein (By similarity). Interacts with METTL17 (PubMed:31487196). Cytoplasm Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mS27 family. tRNA binding RNA binding cytoplasm mitochondrion mitochondrial small ribosomal subunit ribosome regulation of translation cell proliferation rRNA binding positive regulation of mitochondrial translation mitochondrial ribosome binding uc007rpn.1 uc007rpn.2 uc007rpn.3 
ENSMUST00000052266.15 Exoc4 ENSMUST00000052266.15 exocyst complex component 4, transcript variant 1 (from RefSeq NM_009148.4) ENSMUST00000052266.1 ENSMUST00000052266.10 ENSMUST00000052266.11 ENSMUST00000052266.12 ENSMUST00000052266.13 ENSMUST00000052266.14 ENSMUST00000052266.2 ENSMUST00000052266.3 ENSMUST00000052266.4 ENSMUST00000052266.5 ENSMUST00000052266.6 ENSMUST00000052266.7 ENSMUST00000052266.8 ENSMUST00000052266.9 EXOC4_MOUSE NM_009148 O35382 Sec8 Sec8l1 uc009bgt.1 uc009bgt.2 uc009bgt.3 uc009bgt.4 Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP. Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (By similarity). Interacts with SLC6A9 (By similarity). O35382; O35250: Exoc7; NbExp=2; IntAct=EBI-772648, EBI-775332; Midbody, Midbody ring Cell projection Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with CNTRL/centriolin at the midbody ring (By similarity). Localizes at the leading edge of migrating cells (By similarity). Expressed in the striatum (at protein level). Belongs to the SEC8 family. exocyst protein binding cytoplasm plasma membrane microvillus protein targeting to membrane exocytosis Golgi to plasma membrane transport vesicle docking involved in exocytosis chemical synaptic transmission synaptic vesicle postsynaptic density protein transport Ral GTPase binding establishment of cell polarity PDZ domain binding growth cone cell leading edge growth cone membrane macromolecular complex myelin sheath abaxonal region cell projection neuron projection neuronal cell body dendritic shaft myelin sheath membrane biogenesis macromolecular complex binding synapse protein N-terminus binding paraxial mesoderm formation oligodendrocyte differentiation positive regulation of calcium-mediated signaling regulation of protein transport Golgi to transport vesicle transport vesicle tethering involved in exocytosis Flemming body endosome Golgi apparatus uc009bgt.1 uc009bgt.2 uc009bgt.3 uc009bgt.4 
ENSMUST00000052277.5 Iqub ENSMUST00000052277.5 IQ motif and ubiquitin domain containing (from RefSeq NM_172535.3) B2RQH8 ENSMUST00000052277.1 ENSMUST00000052277.2 ENSMUST00000052277.3 ENSMUST00000052277.4 IQUB_MOUSE NM_172535 Q3TT98 Q8CDK3 uc009bbr.1 uc009bbr.2 uc009bbr.3 Anchors the radial spoke 1 (RS1) complex to the A microtubule of outer doublet microtubules in axonemes (PubMed:36417862, PubMed:36355624). The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum (PubMed:36417862, PubMed:36355624). May play a role in inhibiting signaling via MAPK1/ERK2 and MAPK3/ERK1 (PubMed:36355624). Additionally, may play a role in the functioning of cilia (PubMed:21289087). Not required for the functioning of tracheal or ependymal cilia (PubMed:36417862). Component of the axonemal radial spoke 1 (RS1) complex, at least composed of spoke head proteins RSPH1, RSPH3B, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB (PubMed:36417862). Does not appear to be part of radial spoke complexes 2 or 3 (RS2 or RS3) (Probable). Interacts with CALM1 (PubMed:36417862). Interacts with DNAJB13 (PubMed:36417862). Interacts with DYNLL2 (PubMed:36417862). Interacts with NME5 (PubMed:36417862). Interacts with RSPH3 (By similarity). Interacts with RSPH9 (PubMed:36417862). Interacts with ZMYND10 (By similarity). Interacts with calmodulin; the interaction occurs in conditions of low but not high calcium (By similarity). Cytoplasm, cytoskeleton, flagellum axoneme Cell projection, cilium Note=Localizes to the axoneme of sperm cells and the cilia of tracheal epithelial cells. Expressed in the flagellum of sperm cells and cilia of tracheal epithelial cells (at protein level) (PubMed:36417862). High expression in testis, also present in brain and lung (PubMed:36417862). Leads to an absence of radial spoke 1 (RS1) complex from sperm axonemes (PubMed:36417862). Leads to flagellar bending defects in sperm cells, and consequently abnormal flagellar beating and asthenospermia (reduced sperm motility) (PubMed:36417862, PubMed:36355624). Male mice are infertile, no effect on female fertility (PubMed:36417862, PubMed:36355624). Elongated cilia (PubMed:21289087). Increases levels of phosphorylated MAPK1/ERK2 and MAPK3/ERK1 (PubMed:36355624). acrosomal vesicle protein binding smoothened signaling pathway cell projection organization motile cilium cilium assembly uc009bbr.1 uc009bbr.2 uc009bbr.3 
ENSMUST00000052281.6 Epop ENSMUST00000052281.6 elongin BC and polycomb repressive complex 2 associated protein (from RefSeq NM_175332.3) E13 ENSMUST00000052281.1 ENSMUST00000052281.2 ENSMUST00000052281.3 ENSMUST00000052281.4 ENSMUST00000052281.5 EPOP_MOUSE Epop NM_175332 Q7TNS8 Q8BN79 Q99JK6 uc007leg.1 uc007leg.2 uc007leg.3 Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs) (PubMed:27863225, PubMed:27863226). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex (PubMed:27863225, PubMed:27863226). Interaction with USP7 promotes deubiquitination of H2B at promoter sites (PubMed:27863226). Acts as a regulator of neuronal differentiation (PubMed:23180766). Associates with the PRC2 complex, which consists of the core components EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:21732481, PubMed:27462409, PubMed:27863225, PubMed:27863226). Within the complex, interacts with SUZ12 (via C2H2 zinc finger domain); competes with JARID2 for SUZ12 binding (By similarity). Associates with the elongin BC complex (PubMed:27863225, PubMed:27863226). Interacts with USP7 (PubMed:27863226). Q7TNS8; Q921E6: Eed; NbExp=2; IntAct=EBI-16024836, EBI-904301; Q7TNS8; Q9D902: Gtf2e2; NbExp=2; IntAct=EBI-16024836, EBI-309435; Q7TNS8; Q80U70: Suz12; NbExp=2; IntAct=EBI-16024836, EBI-2526494; Nucleus Chromosome Note=Localizes at both PRC2/EZH2 sites (H3K27me3) and broad H3K4me3 sites on chromatin of embryonic stem cells (ESCs) (PubMed:27863226). Highly expressed in embryonic stem cells (ESCs) during embryogenesis and in the adult brain (PubMed:23180766). Highly expressed in embryonic stem cells (ESCs) during embryogenesis: expression starts from 4-cell stage. The BC-box, which mediates binding to the elongin BC complex. Sequence=AAH06054.1; Type=Erroneous initiation; Evidence=; chromatin binding protein binding nucleus chromosome chromatin organization regulation of transcription from RNA polymerase II promoter histone H2B conserved C-terminal lysine deubiquitination neuron fate commitment stem cell differentiation ESC/E(Z) complex elongin complex uc007leg.1 uc007leg.2 uc007leg.3 
ENSMUST00000052283.7 Mageb16 ENSMUST00000052283.7 MAGE family member B16, transcript variant 1 (from RefSeq NM_028025.1) ENSMUST00000052283.1 ENSMUST00000052283.2 ENSMUST00000052283.3 ENSMUST00000052283.4 ENSMUST00000052283.5 ENSMUST00000052283.6 MAGBG_MOUSE NM_028025 Q3TJP9 Q9CWV4 uc009trc.1 uc009trc.2 uc009trc.3 molecular_function cellular_component biological_process uc009trc.1 uc009trc.2 uc009trc.3 
ENSMUST00000052286.16 Plac9 ENSMUST00000052286.16 placenta specific 9 (from RefSeq NM_207229.3) ENSMUST00000052286.1 ENSMUST00000052286.10 ENSMUST00000052286.11 ENSMUST00000052286.12 ENSMUST00000052286.13 ENSMUST00000052286.14 ENSMUST00000052286.15 ENSMUST00000052286.2 ENSMUST00000052286.3 ENSMUST00000052286.4 ENSMUST00000052286.5 ENSMUST00000052286.6 ENSMUST00000052286.7 ENSMUST00000052286.8 ENSMUST00000052286.9 NM_207229 PLAC9_MOUSE Q3V2D9 Q8K262 uc007srw.1 uc007srw.2 uc007srw.3 uc007srw.4 uc007srw.5 Secreted Highly expressed in placenta, and weakly in ovary, testis, and lung. Belongs to the PLAC9 family. molecular_function extracellular region extracellular space biological_process uc007srw.1 uc007srw.2 uc007srw.3 uc007srw.4 uc007srw.5 
ENSMUST00000052315.13 Gm44502 ENSMUST00000052315.13 predicted readthrough transcript (NMD candidate), 44502 (from RefSeq NR_004843.2) A0A2R8VJW3 A0A2R8VJW3_MOUSE ENSMUST00000052315.1 ENSMUST00000052315.10 ENSMUST00000052315.11 ENSMUST00000052315.12 ENSMUST00000052315.2 ENSMUST00000052315.3 ENSMUST00000052315.4 ENSMUST00000052315.5 ENSMUST00000052315.6 ENSMUST00000052315.7 ENSMUST00000052315.8 ENSMUST00000052315.9 Gm44502 NR_004843 uc289aqt.1 uc289aqt.2 This locus represents naturally occurring read-through transcription between the neighboring choline kinase beta (Chkb) and carnitine palmitoyltransferase 1b, muscle (Cpt1b) genes. Similar read-through transcription has also been identified between the homologous genes in human and rat. These read-through transcripts are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to produce a protein; the functional significance of these transcripts has yet to be determined. [provided by RefSeq, Nov 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC090627.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 12651, 12895 ##RefSeq-Attributes-END## Lipid metabolism. Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. Belongs to the choline/ethanolamine kinase family. kinase activity phosphorylation glycerophospholipid biosynthetic process uc289aqt.1 uc289aqt.2 
ENSMUST00000052337.4 2310079G19Rik ENSMUST00000052337.4 RIKEN cDNA 2310079G19 gene (from RefSeq NM_027173.1) 2310079G19Rik ENSMUST00000052337.1 ENSMUST00000052337.2 ENSMUST00000052337.3 NM_027173 Q9D6L6 Q9D6L6_MOUSE uc012ahs.1 uc012ahs.2 uc012ahs.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the PMG family. molecular_function cellular_component biological_process uc012ahs.1 uc012ahs.2 uc012ahs.3 
ENSMUST00000052346.10 Llgl1 ENSMUST00000052346.10 LLGL1 scribble cell polarity complex component, transcript variant 7 (from RefSeq NR_166136.1) A0A0R4J0S4 A0A0R4J0S4_MOUSE ENSMUST00000052346.1 ENSMUST00000052346.2 ENSMUST00000052346.3 ENSMUST00000052346.4 ENSMUST00000052346.5 ENSMUST00000052346.6 ENSMUST00000052346.7 ENSMUST00000052346.8 ENSMUST00000052346.9 Llgl1 NR_166136 uc007jge.1 uc007jge.2 uc007jge.3 uc007jge.4 Belongs to the WD repeat L(2)GL family. cytoplasm protein kinase binding cortical actin cytoskeleton cortical actin cytoskeleton organization macromolecular complex assembly uc007jge.1 uc007jge.2 uc007jge.3 uc007jge.4 
ENSMUST00000052347.8 Mc2r ENSMUST00000052347.8 melanocortin 2 receptor, transcript variant 2 (from RefSeq NM_008560.3) ACTHR_MOUSE Acthr ENSMUST00000052347.1 ENSMUST00000052347.2 ENSMUST00000052347.3 ENSMUST00000052347.4 ENSMUST00000052347.5 ENSMUST00000052347.6 ENSMUST00000052347.7 NM_008560 Q64326 uc008fnm.1 uc008fnm.2 uc008fnm.3 uc008fnm.4 uc008fnm.5 Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH) (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. placenta development G-protein coupled receptor activity melanocortin receptor activity corticotropin receptor activity cytoplasm plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway neuropeptide signaling pathway membrane integral component of membrane uc008fnm.1 uc008fnm.2 uc008fnm.3 uc008fnm.4 uc008fnm.5 
ENSMUST00000052348.12 Slc22a18 ENSMUST00000052348.12 solute carrier family 22 (organic cation transporter), member 18, transcript variant 1 (from RefSeq NM_008767.3) A0A0R4J0P7 A0A0R4J0P7_MOUSE ENSMUST00000052348.1 ENSMUST00000052348.10 ENSMUST00000052348.11 ENSMUST00000052348.2 ENSMUST00000052348.3 ENSMUST00000052348.4 ENSMUST00000052348.5 ENSMUST00000052348.6 ENSMUST00000052348.7 ENSMUST00000052348.8 ENSMUST00000052348.9 NM_008767 Slc22a18 uc009kpg.1 uc009kpg.2 uc009kpg.3 uc009kpg.4 Membrane ; Multi- pass membrane protein nuclear envelope cytoplasm integral component of plasma membrane membrane integral component of membrane apical plasma membrane transmembrane transporter activity ubiquitin protein ligase binding xenobiotic transport transmembrane transport drug transmembrane export uc009kpg.1 uc009kpg.2 uc009kpg.3 uc009kpg.4 
ENSMUST00000052355.15 Nup37 ENSMUST00000052355.15 nucleoporin 37, transcript variant 2 (from RefSeq NM_027191.2) ENSMUST00000052355.1 ENSMUST00000052355.10 ENSMUST00000052355.11 ENSMUST00000052355.12 ENSMUST00000052355.13 ENSMUST00000052355.14 ENSMUST00000052355.2 ENSMUST00000052355.3 ENSMUST00000052355.4 ENSMUST00000052355.5 ENSMUST00000052355.6 ENSMUST00000052355.7 ENSMUST00000052355.8 ENSMUST00000052355.9 NM_027191 NUP37_MOUSE Q9CWU9 Q9CZ80 uc007gre.1 uc007gre.2 uc007gre.3 uc007gre.4 Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation (By similarity). Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13 (By similarity). Chromosome, centromere, kinetochore Nucleus, nuclear pore complex chromosome, centromeric region kinetochore condensed chromosome kinetochore molecular_function nucleus nuclear pore nucleoplasm chromosome cell cycle chromosome segregation protein transport nuclear pore outer ring mRNA transport cell division uc007gre.1 uc007gre.2 uc007gre.3 uc007gre.4 
ENSMUST00000052366.5 Pcdhb1 ENSMUST00000052366.5 protocadherin beta 1 (from RefSeq NM_053126.2) ENSMUST00000052366.1 ENSMUST00000052366.2 ENSMUST00000052366.3 ENSMUST00000052366.4 NM_053126 Pcdhb1 Q91Y08 Q91Y08_MOUSE uc008epm.1 uc008epm.2 uc008epm.3 calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane metal ion binding uc008epm.1 uc008epm.2 uc008epm.3 
ENSMUST00000052374.13 Rangap1 ENSMUST00000052374.13 RAN GTPase activating protein 1, transcript variant 4 (from RefSeq NR_152441.1) ENSMUST00000052374.1 ENSMUST00000052374.10 ENSMUST00000052374.11 ENSMUST00000052374.12 ENSMUST00000052374.2 ENSMUST00000052374.3 ENSMUST00000052374.4 ENSMUST00000052374.5 ENSMUST00000052374.6 ENSMUST00000052374.7 ENSMUST00000052374.8 ENSMUST00000052374.9 Fug1 NR_152441 P46061 Q60801 Q6NZB5 RAGP1_MOUSE uc007wxb.1 uc007wxb.2 uc007wxb.3 uc007wxb.4 GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:18305100). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (By similarity). Required for postimplantation embryonic development (PubMed:8314081). Homodimer (PubMed:7891706). Interacts with RAN (PubMed:7891706). Forms a complex with RANBP2/NUP358, NXF1 and NXT1 (By similarity). Forms a tight complex in association with RANBP2 and UBE2I/UBC9, the ubiquitin-conjugating enzyme E2 (PubMed:11853669). Interacts with UBE2I; the interaction conjugates SUMO1 to RANGAP1, and subsequently stabilizes interactions of sumoylated RANGAP1 with RANBP2 (PubMed:9456312, PubMed:18305100, PubMed:11853669). The complex composed of RANBP2, SUMO1, RANGAP1 and UBE2I associates with nuclear pore complexes (By similarity). Identified in a complex composed of RAN, RANBP2, sumoylated RANGAP1, UBE2I and XPO1 (By similarity). Interacts with TRAF6 (By similarity). Interacts with SUMO1 and SENP1 (By similarity). Interacts (when sumoylated) with MYCBP2; interaction inhibits MYCBP2 E3 ubiquitin-protein ligase activity and promotes MYCBP2 translocation to the nucleus (PubMed:26304119). Cytoplasm cleus, nucleoplasm Nucleus envelope romosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Note=Cytoplasmic during interphase (PubMed:26506250). Detected at the nuclear envelope during interphase (PubMed:9442102, PubMed:9456312, PubMed:26506250). Shuttles between nucleus and cytoplasm (PubMed:26506250). Targeted to the nuclear pores after sumoylation. During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation (By similarity). Detected in adult brain, liver, kidney, intestine, uterus and ovary. Detected in embryos at 7.5 dpc, but not at 6 dpc. Phosphorylation occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBE2I, on nuclear pore complex (NPC) diassembly and during mitosis. Sumoylated (PubMed:26506250, PubMed:11853669). Sumoylation is necessary for targeting to the nuclear envelope (NE) (PubMed:16469311). Sumoylation is necessary for association with mitotic spindles and kinetochores during mitosis (By similarity). Also required for interaction with RANBP2 and is mediated by UBE2I (PubMed:9456312, PubMed:11853669). Desumoylated by HINT1 (PubMed:31088288). Embryonic development is arrested around 6 dpc. Belongs to the RNA1 family. chromosome, centromeric region kinetochore condensed chromosome kinetochore RNA binding GTPase activator activity nucleus nuclear envelope nuclear pore nucleoplasm chromosome cytoplasm spindle cytosol cytoskeleton signal transduction Ran GTPase binding aggresome dendrite ubiquitin protein ligase binding nuclear membrane intracellular membrane-bounded organelle nuclear pore cytoplasmic filaments negative regulation of protein export from nucleus perinuclear region of cytoplasm response to axon injury cellular response to peptide hormone stimulus mitotic spindle activation of GTPase activity axon cytoplasm cellular response to vasopressin cytoplasmic periphery of the nuclear pore complex uc007wxb.1 uc007wxb.2 uc007wxb.3 uc007wxb.4 
ENSMUST00000052375.8 Rgs13 ENSMUST00000052375.8 regulator of G-protein signaling 13 (from RefSeq NM_153171.5) ENSMUST00000052375.1 ENSMUST00000052375.2 ENSMUST00000052375.3 ENSMUST00000052375.4 ENSMUST00000052375.5 ENSMUST00000052375.6 ENSMUST00000052375.7 NM_153171 Q8K443 RGS13_MOUSE uc007cxi.1 uc007cxi.2 uc007cxi.3 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha. Q8K443; Q9CZW5: Tomm70; NbExp=12; IntAct=EBI-645999, EBI-642469; protein binding nucleus cytosol plasma membrane G-protein coupled receptor signaling pathway negative regulation of signal transduction negative regulation of G-protein coupled receptor protein signaling pathway uc007cxi.1 uc007cxi.2 uc007cxi.3 
ENSMUST00000052380.5 Insl6 ENSMUST00000052380.5 insulin-like 6 (from RefSeq NM_013754.1) ENSMUST00000052380.1 ENSMUST00000052380.2 ENSMUST00000052380.3 ENSMUST00000052380.4 INSL6_MOUSE NM_013754 Q9QY05 uc008hdd.1 uc008hdd.2 uc008hdd.3 May have a role in sperm development and fertilization. Secreted Belongs to the insulin family. hormone activity extracellular region signal transduction spermatogenesis spermatid development male gonad development fertilization flagellated sperm motility negative regulation of apoptotic process uc008hdd.1 uc008hdd.2 uc008hdd.3 
ENSMUST00000052387.5 Pcdhb14 ENSMUST00000052387.5 protocadherin beta 14 (from RefSeq NM_053139.3) ENSMUST00000052387.1 ENSMUST00000052387.2 ENSMUST00000052387.3 ENSMUST00000052387.4 NM_053139 PCDBE_MOUSE Q6PB90 Q8CCT0 Q91Y05 uc008epz.1 uc008epz.2 uc008epz.3 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epz.1 uc008epz.2 uc008epz.3 
ENSMUST00000052413.12 Lcp2 ENSMUST00000052413.12 lymphocyte cytosolic protein 2 (from RefSeq NM_010696.4) ENSMUST00000052413.1 ENSMUST00000052413.10 ENSMUST00000052413.11 ENSMUST00000052413.2 ENSMUST00000052413.3 ENSMUST00000052413.4 ENSMUST00000052413.5 ENSMUST00000052413.6 ENSMUST00000052413.7 ENSMUST00000052413.8 ENSMUST00000052413.9 LCP2_MOUSE NM_010696 Q60787 Q922M0 uc007ikv.1 uc007ikv.2 uc007ikv.3 Involved in T-cell antigen receptor mediated signaling. Interacts with SHB. Interacts with PRAM1 (By similarity). Interacts with SLA (PubMed:10662792). Interacts with GRB2 (PubMed:7706237). Interacts with CBLB (PubMed:10646608). Interacts (via SH2 domain) with CD6 (via tyrosine phosphorylated C-terminus) (PubMed:16914752, PubMed:24584089). Interacts with FYB1 and the phosphorylated form of FYB2 (By similarity). Q60787; Q61003: Cd6; NbExp=9; IntAct=EBI-5324248, EBI-12601992; Q60787; O35601: Fyb1; NbExp=7; IntAct=EBI-5324248, EBI-7353747; Q60787; O89100: Grap2; NbExp=7; IntAct=EBI-5324248, EBI-642151; Q60787; O54957: Lat; NbExp=8; IntAct=EBI-5324248, EBI-6390034; Cytoplasm Highly expressed in spleen, thymus, and peripheral blood leukocytes. The SH2 domain mediates interaction with SHB. Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components (By similarity). protein binding cytoplasm cytosol cell-cell junction transmembrane receptor protein tyrosine kinase signaling pathway intracellular signal transduction TCR signalosome plasma membrane raft mast cell activation positive regulation of protein kinase activity cytokine secretion T cell receptor signaling pathway uc007ikv.1 uc007ikv.2 uc007ikv.3 
ENSMUST00000052416.4 Lkaaear1 ENSMUST00000052416.4 LKAAEAR motif containing 1 (IKAAEAR murine motif), transcript variant 2 (from RefSeq NM_199023.3) ENSMUST00000052416.1 ENSMUST00000052416.2 ENSMUST00000052416.3 LKAM1_MOUSE NM_199023 Q5I0W3 Q8BIG2 uc008onh.1 uc008onh.2 uc008onh.3 molecular_function cellular_component biological_process uc008onh.1 uc008onh.2 uc008onh.3 
ENSMUST00000052431.12 Armcx6 ENSMUST00000052431.12 armadillo repeat containing, X-linked 6 (from RefSeq NM_001007578.2) A2AKS3 ARMX6_MOUSE ENSMUST00000052431.1 ENSMUST00000052431.10 ENSMUST00000052431.11 ENSMUST00000052431.2 ENSMUST00000052431.3 ENSMUST00000052431.4 ENSMUST00000052431.5 ENSMUST00000052431.6 ENSMUST00000052431.7 ENSMUST00000052431.8 ENSMUST00000052431.9 NM_001007578 Q3TUH4 Q8K3A6 uc012hom.1 uc012hom.2 uc012hom.3 May regulate the dynamics and distribution of mitochondria in neural cells. Mitochondrion Mitochondrion outer membrane ; Single- pass membrane protein Highly expressed in the developing neural tissues, neural crest derivatives and hind limbs. Also widely expressed in the adult nervous tissue, especially in the forebrain, including the cerebral cortex, hippocampus and thalamus. Belongs to the eutherian X-chromosome-specific Armcx family. molecular_function cellular_component mitochondrion mitochondrial outer membrane biological_process membrane integral component of membrane uc012hom.1 uc012hom.2 uc012hom.3 
ENSMUST00000052437.6 Lrrc25 ENSMUST00000052437.6 leucine rich repeat containing 25 (from RefSeq NM_153074.4) ENSMUST00000052437.1 ENSMUST00000052437.2 ENSMUST00000052437.3 ENSMUST00000052437.4 ENSMUST00000052437.5 LRC25_MOUSE Mapa NM_153074 Q3TAD5 Q8K1T1 uc009maz.1 uc009maz.2 uc009maz.3 Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy. Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA. Interacts with RIGI. Interacts with SQSTM1. Interacts with p65/RELA; this interaction promotes the degradation of RELA through autophagy. Membrane ; Single- pass type I membrane protein Cytoplasm molecular_function cellular_component cytoplasm biological_process membrane integral component of membrane uc009maz.1 uc009maz.2 uc009maz.3 
ENSMUST00000052441.12 Slc17a5 ENSMUST00000052441.12 solute carrier family 17 (anion/sugar transporter), member 5, transcript variant 1 (from RefSeq NM_172773.3) ENSMUST00000052441.1 ENSMUST00000052441.10 ENSMUST00000052441.11 ENSMUST00000052441.2 ENSMUST00000052441.3 ENSMUST00000052441.4 ENSMUST00000052441.5 ENSMUST00000052441.6 ENSMUST00000052441.7 ENSMUST00000052441.8 ENSMUST00000052441.9 NM_172773 Q3TE25 Q8BN82 S17A5_MOUSE uc009quo.1 uc009quo.2 uc009quo.3 uc009quo.4 Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport (PubMed:18695252) (By similarity). Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system (By similarity) (PubMed:20007460). Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva (By similarity). Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release (PubMed:18695252, PubMed:23889254). Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties. Reaction=H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N- acetylneuraminate(out); Xref=Rhea:RHEA:28987, ChEBI:CHEBI:15378, ChEBI:CHEBI:35418; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28989; Evidence=; Reaction=D-glucuronate(out) + H(+)(out) = D-glucuronate(in) + H(+)(in); Xref=Rhea:RHEA:72591, ChEBI:CHEBI:15378, ChEBI:CHEBI:58720; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72592; Evidence= Reaction=H(+)(out) + 2 nitrate(out) = H(+)(in) + 2 nitrate(in); Xref=Rhea:RHEA:71539, ChEBI:CHEBI:15378, ChEBI:CHEBI:17632; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71540; Evidence=; Reaction=L-aspartate(out) = L-aspartate(in); Xref=Rhea:RHEA:66332, ChEBI:CHEBI:29991; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66333; Evidence=; Reaction=L-glutamate(out) = L-glutamate(in); Xref=Rhea:RHEA:66336, ChEBI:CHEBI:29985; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66337; Evidence=; Reaction=N-acetyl-L-aspartyl-L-glutamate(out) = N-acetyl-L-aspartyl-L- glutamate(in); Xref=Rhea:RHEA:72599, ChEBI:CHEBI:76931; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72600; Evidence=; Kinetic parameters: KM=0.62 mM for L-aspartate ; Vmax=142 nmol/min/mg enzyme toward L-aspartate ; Basolateral cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BN82-1; Sequence=Displayed; Name=2; IsoId=Q8BN82-2; Sequence=VSP_010484; Name=3; IsoId=Q8BN82-3; Sequence=VSP_010485, VSP_010486; Expressed in hippocampal neurons (at protein level). Mutant mice have smaller size, develop severe tremor and uncoordinated gait associated with marked central nervous system hypomyelination, and die prematurely during the third postnatal week. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. lysosome lysosomal membrane cytosol plasma membrane integral component of plasma membrane amino acid transport response to bacterium sialic acid transmembrane transporter activity symporter activity sialic acid transport membrane integral component of membrane cell junction synaptic vesicle membrane cytoplasmic vesicle synapse transmembrane transport uc009quo.1 uc009quo.2 uc009quo.3 uc009quo.4 
ENSMUST00000052448.4 Kcnk7 ENSMUST00000052448.4 potassium channel, subfamily K, member 7 (from RefSeq NM_010609.4) ENSMUST00000052448.1 ENSMUST00000052448.2 ENSMUST00000052448.3 Kcnk6 Kcnk7 NM_010609 Q9JJ14 Q9JJ14_MOUSE uc008geu.1 uc008geu.2 uc008geu.3 Membrane ulti-pass membrane protein Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. potassium channel activity ion transport potassium ion transport membrane integral component of membrane potassium ion transmembrane transport uc008geu.1 uc008geu.2 uc008geu.3 
ENSMUST00000052455.4 Pigm ENSMUST00000052455.4 phosphatidylinositol glycan anchor biosynthesis, class M (from RefSeq NM_026234.4) ENSMUST00000052455.1 ENSMUST00000052455.2 ENSMUST00000052455.3 NM_026234 PIGM_MOUSE Q8C2R7 Q8C917 Q99J22 Q9D315 uc007dqk.1 uc007dqk.2 uc007dqk.3 uc007dqk.4 Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly (By similarity). Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the PIGM family. mannosyltransferase activity cellular_component endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups mannosylation uc007dqk.1 uc007dqk.2 uc007dqk.3 uc007dqk.4 
ENSMUST00000052457.15 Mtss2 ENSMUST00000052457.15 MTSS I-BAR domain containing 2, transcript variant 1 (from RefSeq NM_198625.3) ENSMUST00000052457.1 ENSMUST00000052457.10 ENSMUST00000052457.11 ENSMUST00000052457.12 ENSMUST00000052457.13 ENSMUST00000052457.14 ENSMUST00000052457.2 ENSMUST00000052457.3 ENSMUST00000052457.4 ENSMUST00000052457.5 ENSMUST00000052457.6 ENSMUST00000052457.7 ENSMUST00000052457.8 ENSMUST00000052457.9 MTSS2_MOUSE Mtss1l NM_198625 Q6P9S0 Q8C7B7 uc009nkx.1 uc009nkx.2 uc009nkx.3 uc009nkx.4 Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling. Interacts (via IMD domain) with RAC1; this interaction may be important to potentiate PDGF-induced RAC1 activation. Cytoplasm Cell projection, ruffle Note=Colocalizes with RAC1 within membrane ruffles. Belongs to the MTSS family. ruffle actin binding actin monomer binding GTPase activator activity phosphatidylinositol-4,5-bisphosphate binding cytoplasm plasma membrane plasma membrane organization lamellipodium cortical actin cytoskeleton ruffle membrane cellular response to platelet-derived growth factor stimulus cell projection Rac GTPase binding membrane organization activation of GTPase activity ruffle assembly lamellipodium organization uc009nkx.1 uc009nkx.2 uc009nkx.3 uc009nkx.4 
ENSMUST00000052458.3 Lrrc38 ENSMUST00000052458.3 leucine rich repeat containing 38 (from RefSeq NM_001162983.1) A2A8J4 A2VDH3 ENSMUST00000052458.1 ENSMUST00000052458.2 LRC38_MOUSE NM_001162983 Q3TVH8 Q8BR15 uc008vqb.1 uc008vqb.2 uc008vqb.3 uc008vqb.4 Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity). Interacts with KCNMA1. Cell membrane ; Single-pass type I membrane protein The transmembrane domain is necessary for interaction with KCNMA1. Sequence=AAI29964.1; Type=Erroneous initiation; Evidence=; voltage-gated potassium channel activity plasma membrane ion transport voltage-gated potassium channel complex membrane integral component of membrane ion channel binding potassium ion transmembrane transport potassium channel activator activity positive regulation of voltage-gated potassium channel activity uc008vqb.1 uc008vqb.2 uc008vqb.3 uc008vqb.4 
ENSMUST00000052478.3 Dmrta1 ENSMUST00000052478.3 doublesex and mab-3 related transcription factor like family A1 (from RefSeq NM_175647.3) A2AL09 DMRTA_MOUSE Dmrt4 ENSMUST00000052478.1 ENSMUST00000052478.2 NM_175647 Q8CFG4 uc008tol.1 uc008tol.2 uc008tol.3 Nucleus Widely expressed, with highest levels in ovary, testis, epididymis, preputial gland, vomeronasal organ, liver, salivary glands and heart. Also expressed throughout the brain with highest levels in the olfactory bulbs and medulla. Detected at similar levels in gonads of both sexes. Expressed in gonads from 11.5 dpc onward. Expressed in the genital ridge at 11.5 dpc and in the seminiferous tubules at 12.5 dpc. Mutant animals are viable and fertile, with no obvious anatomical defects. Ovaries from mutant females may have an elevated number of polyovular follicles. 25% of mutant males consistently exhibit copulatory behavior toward other males. Belongs to the DMRT family. ovarian follicle development DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated protein homodimerization activity sequence-specific DNA binding metal ion binding male mating behavior uc008tol.1 uc008tol.2 uc008tol.3 
ENSMUST00000052499.9 Rps19bp1 ENSMUST00000052499.9 ribosomal protein S19 binding protein 1 (from RefSeq NM_175109.3) AROS_MOUSE Aros ENSMUST00000052499.1 ENSMUST00000052499.2 ENSMUST00000052499.3 ENSMUST00000052499.4 ENSMUST00000052499.5 ENSMUST00000052499.6 ENSMUST00000052499.7 ENSMUST00000052499.8 NM_175109 Q2WFQ7 Q8C6B9 uc007wvm.1 uc007wvm.2 uc007wvm.3 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1. Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with RPS19; the interaction is direct and mediates the integration of RPS19 in state post-A1 (PubMed:16289379). Interacts with SIRT1 (By similarity). Nucleus, nucleolus Widely expressed with higher levels in submaxillary gland and epididymis. Citrullinated by PADI4. Belongs to the AROS family. protein binding nucleus nucleoplasm nucleolus cytosol biological_process enzyme binding uc007wvm.1 uc007wvm.2 uc007wvm.3 
ENSMUST00000052500.6 Cldn34c4 ENSMUST00000052500.6 claudin 34C4 (from RefSeq NM_001281537.1) A2ANA3 A2ANA3_MOUSE Cldn34c4 ENSMUST00000052500.1 ENSMUST00000052500.2 ENSMUST00000052500.3 ENSMUST00000052500.4 ENSMUST00000052500.5 NM_001281537 uc033jsl.1 uc033jsl.2 uc033jsl.3 uc033jsl.4 Cell junction, tight junction Belongs to the claudin family. molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc033jsl.1 uc033jsl.2 uc033jsl.3 uc033jsl.4 
ENSMUST00000052503.8 Gimap7 ENSMUST00000052503.8 GTPase, IMAP family member 7 (from RefSeq NM_146167.3) ENSMUST00000052503.1 ENSMUST00000052503.2 ENSMUST00000052503.3 ENSMUST00000052503.4 ENSMUST00000052503.5 ENSMUST00000052503.6 ENSMUST00000052503.7 Gimap7 NM_146167 Q8R379 Q8R379_MOUSE uc009bvo.1 uc009bvo.2 This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: BC026200.1, AK040029.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. GTPase activity GTP binding lipid particle cytosol identical protein binding protein homodimerization activity intracellular membrane-bounded organelle GTP metabolic process uc009bvo.1 uc009bvo.2 
ENSMUST00000052505.10 Tmem186 ENSMUST00000052505.10 transmembrane protein 186, transcript variant 1 (from RefSeq NM_025708.5) ENSMUST00000052505.1 ENSMUST00000052505.2 ENSMUST00000052505.3 ENSMUST00000052505.4 ENSMUST00000052505.5 ENSMUST00000052505.6 ENSMUST00000052505.7 ENSMUST00000052505.8 ENSMUST00000052505.9 NM_025708 Q8BHA7 Q8BHT1 Q9CR76 TM186_MOUSE Tmem186 uc007ycq.1 uc007ycq.2 uc007ycq.3 As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I. Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186. Interacts with MT- ND3. Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the TMEM186 family. Sequence=BAC25393.1; Type=Frameshift; Evidence=; molecular_function mitochondrion biological_process membrane integral component of membrane uc007ycq.1 uc007ycq.2 uc007ycq.3 
ENSMUST00000052509.6 Zfp771 ENSMUST00000052509.6 zinc finger protein 771, transcript variant 1 (from RefSeq NM_177362.4) B2RSX6 ENSMUST00000052509.1 ENSMUST00000052509.2 ENSMUST00000052509.3 ENSMUST00000052509.4 ENSMUST00000052509.5 NM_177362 Q6P5I0 Q8BJ90 ZN771_MOUSE Znf771 uc009juv.1 uc009juv.2 uc009juv.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus nucleolus biological_process metal ion binding uc009juv.1 uc009juv.2 uc009juv.3 
ENSMUST00000052512.4 Krtap24-1 ENSMUST00000052512.4 keratin associated protein 24-1 (from RefSeq NM_001163141.1) ENSMUST00000052512.1 ENSMUST00000052512.2 ENSMUST00000052512.3 G3X9A2 G3X9A2_MOUSE Krtap24-1 NM_001163141 uc012ahr.1 uc012ahr.2 uc012ahr.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the PMG family. molecular_function structural molecule activity cellular_component biological_process keratin filament uc012ahr.1 uc012ahr.2 uc012ahr.3 
ENSMUST00000052514.6 Slc38a9 ENSMUST00000052514.6 solute carrier family 38, member 9 (from RefSeq NM_178746.4) ENSMUST00000052514.1 ENSMUST00000052514.2 ENSMUST00000052514.3 ENSMUST00000052514.4 ENSMUST00000052514.5 NM_178746 Q80W70 Q8BGD6 Q8C5C3 S38A9_MOUSE Slc38a9 uc007rwo.1 uc007rwo.2 uc007rwo.3 uc007rwo.4 Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids. Acts as an arginine sensor. Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation. However, the transport mechanism is not well defined and the role of sodium is not clear. Can disassemble the lysosomal folliculin complex (LFC), and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC. Acts as an cholesterol sensor that conveys increases in lysosomal cholesterol, leading to lysosomal recruitment and activation of mTORC1 via the Rag GTPases. Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency. Reaction=L-leucine(in) = L-leucine(out); Xref=Rhea:RHEA:73011, ChEBI:CHEBI:57427; Evidence=; Reaction=L-tyrosine(in) = L-tyrosine(out); Xref=Rhea:RHEA:68572, ChEBI:CHEBI:58315; Evidence=; Reaction=L-glutamine(out) = L-glutamine(in); Xref=Rhea:RHEA:73419, ChEBI:CHEBI:58359; Evidence=; Reaction=L-asparagine(out) = L-asparagine(in); Xref=Rhea:RHEA:73423, ChEBI:CHEBI:58048; Evidence=; Associated component of the Ragulator complex (composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5). Associated component of the Rag GTPases heterodimers (composed of RRAGA, RRAGB, RRAGC and RRAGD); this interaction is independent of the Ragulator complex but depends on the nucleotide loading state of the Rag GTPase heterodimer. Interacts with TM4SF5. Interacts with NPC1; this interaction inhibits cholesterol-mediated mTORC1 activation via its sterol transport activity. Lysosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein The cytosolic N-terminus part of the protein mediates interaction with the Ragulator complex. The cytosolic N-terminus part of the protein destabilizes the LFC and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC. The cytosolic N-terminus part of the protein mediates interaction with the Rag GTPase heterodimer in a RRAGA GDP-loaded state dependent and upon arginine binding, leading to the GDP release and SLC38A9 dissociation from the activated Rag GTPase heterodimer (By similarity). The cytosolic N-terminus part of the protein exists at least in two distinct conformations; The first is when the N-terminus is bound snugly in the arginine binding site (in the absence of arginine, low luminal arginine state) and the second is where the N-terminus is released and the substrate-binding site is occupied by arginine (in the presence of arginine, high luminal arginine state) (By similarity). the CARC and CRAC motifs mediate binding to cholesterol. Glycosylated. Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily. Sequence=BAC37465.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; amino acid transmembrane transport nucleoplasm lysosome lysosomal membrane endosome late endosome amino acid transport amino acid transmembrane transporter activity L-leucine transmembrane transporter activity branched-chain amino acid transport neutral amino acid transport membrane integral component of membrane late endosome membrane positive regulation of TOR signaling intracellular membrane-bounded organelle metal ion binding L-arginine transmembrane transporter activity cellular response to amino acid stimulus Ragulator complex cation transmembrane transport L-alpha-amino acid transmembrane transport L-arginine transmembrane transport integral component of lysosomal membrane uc007rwo.1 uc007rwo.2 uc007rwo.3 uc007rwo.4 
ENSMUST00000052521.9 Gas2l2 ENSMUST00000052521.9 growth arrest-specific 2 like 2 (from RefSeq NM_001013759.2) B9EJR3 ENSMUST00000052521.1 ENSMUST00000052521.2 ENSMUST00000052521.3 ENSMUST00000052521.4 ENSMUST00000052521.5 ENSMUST00000052521.6 ENSMUST00000052521.7 ENSMUST00000052521.8 GA2L2_MOUSE NM_001013759 Q5SSG4 uc007koy.1 uc007koy.2 uc007koy.3 uc007koy.4 Involved in the cross-linking of microtubules and microfilaments (By similarity). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (PubMed:23994616). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704). Interacts with ADORA2A (via its cytoplasmic C-terminal domain) (PubMed:23994616). Interacts with GNAS, GNAL, GNAQ, and GNA13 (PubMed:23994616). Interacts with MAPRE1 (PubMed:24706950). Cytoplasm, cytoskeleton Cell membrane Cytoplasm, cytoskeleton, stress fiber Cytoplasm, cytoskeleton, cilium basal body Note=Colocalizes with ADORA2A at neuronal processes (By similarity). Colocalizes with and tracks the tips of microtubule plus ends (By similarity). Expressed in tracheal epithelial cells (at protein level). Knockout mice exhibit a high rate of neonatal death (PubMed:30665704). Mice that survive show signs of hydrocephalus at postnatal days 14 and 21, along with mucus accumulation in multiple sinuses, and remodeling of the nasal cavity (PubMed:30665704). Conditional knockout in tracheal cells lead to isolated cases of hydrocephalus, as well as chronic rhinosinusitis and accumulation of mucus in the nasal cavity, which is caused by impaired mucociliary clearance (PubMed:30665704). Belongs to the GAS2 family. microtubule bundle formation G-protein alpha-subunit binding protein binding cytoplasm cytoskeleton actin filament negative regulation of microtubule depolymerization microtubule binding cytoskeletal adaptor activity regulation of microtubule polymerization or depolymerization microtubule plus-end ciliary basal body positive regulation of G-protein coupled receptor protein signaling pathway actin filament binding regulation of cilium beat frequency involved in ciliary motility protein localization to microtubule plus-end stress fiber microtubule plasma membrane uc007koy.1 uc007koy.2 uc007koy.3 uc007koy.4 
ENSMUST00000052529.4 Ppp1r15b ENSMUST00000052529.4 protein phosphatase 1, regulatory subunit 15B (from RefSeq NM_133819.3) ENSMUST00000052529.1 ENSMUST00000052529.2 ENSMUST00000052529.3 NM_133819 PR15B_MOUSE Q3TC78 Q8BFW3 Q8C390 uc007cpt.1 uc007cpt.2 uc007cpt.3 uc007cpt.4 Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. Interacts with PP1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BFW3-1; Sequence=Displayed; Name=2; IsoId=Q8BFW3-2; Sequence=VSP_031652; Mice are born at the expected Mendelian ratio, but exhibit severe growth retardation and impaired erythropoiesis. None survive the first day of postnatal life. PPP1R15A-PPP1R15B double- knockout embryos do not develop past the preimplantation period. Belongs to the PPP1R15 family. protein phosphatase type 1 complex negative regulation of protein phosphorylation cytoplasm endoplasmic reticulum regulation of translation regulation of translational initiation response to oxidative stress ER overload response protein phosphatase regulator activity positive regulation of phosphoprotein phosphatase activity response to endoplasmic reticulum stress response to hydrogen peroxide peptidyl-serine dephosphorylation negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation uc007cpt.1 uc007cpt.2 uc007cpt.3 uc007cpt.4 
ENSMUST00000052550.13 Lrp1b ENSMUST00000052550.13 low density lipoprotein-related protein 1B (from RefSeq NM_053011.2) A2API5 A2API5_MOUSE ENSMUST00000052550.1 ENSMUST00000052550.10 ENSMUST00000052550.11 ENSMUST00000052550.12 ENSMUST00000052550.2 ENSMUST00000052550.3 ENSMUST00000052550.4 ENSMUST00000052550.5 ENSMUST00000052550.6 ENSMUST00000052550.7 ENSMUST00000052550.8 ENSMUST00000052550.9 Lrp1b NM_053011 uc008jon.1 uc008jon.2 uc008jon.3 Membrane ; Single- pass type I membrane protein Belongs to the LDLR family. Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding membrane integral component of membrane receptor complex uc008jon.1 uc008jon.2 uc008jon.3 
ENSMUST00000052556.5 Abhd17b ENSMUST00000052556.5 abhydrolase domain containing 17B (from RefSeq NM_146096.3) AB17B_MOUSE Abhd17b ENSMUST00000052556.1 ENSMUST00000052556.2 ENSMUST00000052556.3 ENSMUST00000052556.4 NM_146096 Q58EV9 Q7M759 Q8K275 uc008gzb.1 uc008gzb.2 uc008gzb.3 Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:27307232). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:27307232). Has depalmitoylating activity towards GAP43 (PubMed:27307232). Has depalmitoylating activity towards MAP6 (PubMed:28521134). Has depalmitoylating activity towards NRAS (By similarity). Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; EC=3.1.2.22; Evidence=; Cell membrane ; Lipid-anchor ; Cytoplasmic side Recycling endosome membrane ; Lipid-anchor ; Cytoplasmic side Cell projection, dendritic spine Postsynaptic density membrane Expressed in brain. Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. protein depalmitoylation endosome plasma membrane palmitoyl-(protein) hydrolase activity postsynaptic density membrane hydrolase activity protein palmitoylation cell junction cell projection dendritic spine synapse postsynaptic membrane recycling endosome membrane glutamatergic synapse anchored component of postsynaptic density membrane anchored component of postsynaptic recycling endosome membrane regulation of protein localization to synapse negative regulation of protein localization to microtubule regulation of dendritic spine maintenance positive regulation of protein localization to endosome uc008gzb.1 uc008gzb.2 uc008gzb.3 
ENSMUST00000052560.7 Or5au1 ENSMUST00000052560.7 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt B2RVX8) B2RVX8 B2RVX8_MOUSE ENSMUST00000052560.1 ENSMUST00000052560.2 ENSMUST00000052560.3 ENSMUST00000052560.4 ENSMUST00000052560.5 ENSMUST00000052560.6 Olfr1514 Olfr221 Or5au1 uc288tsq.1 uc288tsq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tsq.1 uc288tsq.2 
ENSMUST00000052566.8 Tmem199 ENSMUST00000052566.8 transmembrane protein 199 (from RefSeq NM_199199.3) ENSMUST00000052566.1 ENSMUST00000052566.2 ENSMUST00000052566.3 ENSMUST00000052566.4 ENSMUST00000052566.5 ENSMUST00000052566.6 ENSMUST00000052566.7 NM_199199 Q5SYH2 TM199_MOUSE uc007kjn.1 uc007kjn.2 uc007kjn.3 Accessory component of the proton-transporting vacuolar (V)- ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity). Accessory component of the multisubunit proton-transporting vacuolar (V)-ATPase protein pump. Cytoplasmic vesicle, COPI-coated vesicle membrane ; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Partial colocalization with GOLGB1. molecular_function lysosome endoplasmic reticulum endoplasmic reticulum membrane cellular iron ion homeostasis lysosomal lumen acidification membrane integral component of membrane vacuolar proton-transporting V-type ATPase complex COPI-coated vesicle membrane cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment membrane cellular response to increased oxygen levels vacuolar proton-transporting V-type ATPase complex assembly lysosomal protein catabolic process uc007kjn.1 uc007kjn.2 uc007kjn.3 
ENSMUST00000052596.3 Cby3 ENSMUST00000052596.3 chibby family member 3 (from RefSeq NM_029691.1) Cby3 ENSMUST00000052596.1 ENSMUST00000052596.2 NM_029691 Z4YJN4 Z4YJN4_MOUSE uc007isi.1 uc007isi.2 uc007isi.1 uc007isi.2 
ENSMUST00000052601.4 Defb14 ENSMUST00000052601.4 defensin beta 14 (from RefSeq NM_183026.3) DFB14_MOUSE ENSMUST00000052601.1 ENSMUST00000052601.2 ENSMUST00000052601.3 NM_183026 Q14BD1 Q7TNV9 uc009lai.1 uc009lai.2 uc009lai.3 uc009lai.4 Has antibacterial activity. Secreted Belongs to the beta-defensin family. extracellular region extracellular space chemotaxis defense response CCR6 chemokine receptor binding chemoattractant activity defense response to bacterium positive chemotaxis cell chemotaxis uc009lai.1 uc009lai.2 uc009lai.3 uc009lai.4 
ENSMUST00000052602.6 Nhsl3 ENSMUST00000052602.6 NHS like 3, transcript variant 1 (from RefSeq NM_001033189.4) A2A7S8 A2A7S9 ENSMUST00000052602.1 ENSMUST00000052602.2 ENSMUST00000052602.3 ENSMUST00000052602.4 ENSMUST00000052602.5 Kiaa1522 NHSL3_MOUSE NM_001033189 Q3U356 Q3U437 Q3V3N0 Q6ZPN9 Q8K0K8 uc008uwn.1 uc008uwn.2 Able to directly activate the TNF-NFkappaB signaling pathway. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=A2A7S8-1; Sequence=Displayed; Name=2; IsoId=A2A7S8-2; Sequence=VSP_029460; Name=3; IsoId=A2A7S8-3; Sequence=VSP_029459; Name=4; IsoId=A2A7S8-4; Sequence=VSP_029461; Sequence=BAC98192.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component cell differentiation uc008uwn.1 uc008uwn.2 
ENSMUST00000052605.8 Ceacam19 ENSMUST00000052605.8 CEA cell adhesion molecule 19 (from RefSeq NM_177036.5) Ceacam19 ENSMUST00000052605.1 ENSMUST00000052605.2 ENSMUST00000052605.3 ENSMUST00000052605.4 ENSMUST00000052605.5 ENSMUST00000052605.6 ENSMUST00000052605.7 NM_177036 Q3TQ88 Q3TQ88_MOUSE uc009fnn.1 uc009fnn.2 Belongs to the immunoglobulin superfamily. CEA family. molecular_function cellular_component biological_process membrane integral component of membrane uc009fnn.1 uc009fnn.2 
ENSMUST00000052609.9 Dlx5 ENSMUST00000052609.9 distal-less homeobox 5, transcript variant 1 (from RefSeq NM_010056.3) Dlx5 ENSMUST00000052609.1 ENSMUST00000052609.2 ENSMUST00000052609.3 ENSMUST00000052609.4 ENSMUST00000052609.5 ENSMUST00000052609.6 ENSMUST00000052609.7 ENSMUST00000052609.8 NM_010056 Q3TYA7 Q3TYA7_MOUSE uc009awz.1 uc009awz.2 uc009awz.3 uc009awz.4 Nucleus Belongs to the distal-less homeobox family. DNA binding nucleus regulation of transcription, DNA-templated cell proliferation sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated uc009awz.1 uc009awz.2 uc009awz.3 uc009awz.4 
ENSMUST00000052622.6 Tcim ENSMUST00000052622.6 transcriptional and immune response regulator (from RefSeq NM_026931.3) ENSMUST00000052622.1 ENSMUST00000052622.2 ENSMUST00000052622.3 ENSMUST00000052622.4 ENSMUST00000052622.5 NM_026931 Q9D915 TCIM_MOUSE Tc1 Tcim uc009lex.1 uc009lex.2 uc009lex.3 Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (By similarity). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (PubMed:24937306). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (By similarity). Monomer. Interacts with NOTCH2 (via ANK repeats), the interaction inhibits the nuclear translocation of NOTCH2 N2ICD. Interacts (C-terminus) with CBY1 (C-terminus), TCIM competes with CTNNB1 for the interaction with CBY1. Cytoplasm Nucleus Nucleus, nucleolus Nucleus speckle Note=Localizes in nucleus speckles in presence of CBY1. Translocates to the nucleus upon cellular stress such as H(2)O(2). Expressed in liver, expression levels decrease in regenerating liver (PubMed:25985737). In bone marrow, expressed in large progenitor-like cells, cells with ring-shaped nuclei and, at lower, levels in hematopietic stem cell-like cells with round nuclei (at protein level) (PubMed:24937306). Mice have increased number of myeloid and lymphoid cells on peripheral blood compared to wild type controls. Red blood cells are small-sized but increased in number. In bone marrow, cells show higher colony forming units. endothelial cell activation involved in immune response Notch binding nucleus nucleoplasm nucleolus cytoplasm cytosol plasma membrane apoptotic process positive regulation of protein kinase A signaling nuclear speck cellular response to heat negative regulation of apoptotic process regulation of DNA-templated transcription in response to stress negative regulation of Notch signaling pathway positive regulation of protein kinase C activity positive regulation of NIK/NF-kappaB signaling regulation of cell cycle G1/S phase transition regulation of hemopoiesis uc009lex.1 uc009lex.2 uc009lex.3 
ENSMUST00000052629.13 Igsf9 ENSMUST00000052629.13 immunoglobulin superfamily, member 9, transcript variant 2 (from RefSeq NM_001145800.1) Dasm1 ENSMUST00000052629.1 ENSMUST00000052629.10 ENSMUST00000052629.11 ENSMUST00000052629.12 ENSMUST00000052629.2 ENSMUST00000052629.3 ENSMUST00000052629.4 ENSMUST00000052629.5 ENSMUST00000052629.6 ENSMUST00000052629.7 ENSMUST00000052629.8 ENSMUST00000052629.9 Igsf9a NM_001145800 Nrt1 Q05BQ1 Q8R1J8 Q925P4 TUTLA_MOUSE uc007dqn.1 uc007dqn.2 uc007dqn.3 uc007dqn.4 Functions in dendrite outgrowth and synapse maturation. Interacts with MAGI2 and SHANK1. Cell membrane ; Single-pass type I membrane protein Synapse Note=Enriched at the excitatory synapses in mature neurons. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q05BQ1-1; Sequence=Displayed; Name=2; IsoId=Q05BQ1-2; Sequence=VSP_028408, VSP_028409; Expressed in both cell bodies and dendrites of cortical and hippocampal neurons and also cerebellar Purkinje cells (at protein level). Detected in brain during embryonic development at least from 7.5 dpc until 16.5 dpc. Mainly expressed within the dorsal root glanglia, trigeminal glanglia and olfactory epithelium of 10.5 dpc embryos. Expressed to a lower extent in neuroepithelium, retina and hindgut. The PDZ-binding motif mediates interactions with MAGI2 and SHANK1. Belongs to the immunoglobulin superfamily. Turtle family. plasma membrane homophilic cell adhesion via plasma membrane adhesion molecules multicellular organism development nervous system development membrane integral component of membrane dendrite development cell junction cell differentiation axon dendrite synapse regulation of synapse organization inhibitory synapse protein binding involved in cell-cell adhesion uc007dqn.1 uc007dqn.2 uc007dqn.3 uc007dqn.4 
ENSMUST00000052631.8 Snai1 ENSMUST00000052631.8 snail family zinc finger 1 (from RefSeq NM_011427.3) ENSMUST00000052631.1 ENSMUST00000052631.2 ENSMUST00000052631.3 ENSMUST00000052631.4 ENSMUST00000052631.5 ENSMUST00000052631.6 ENSMUST00000052631.7 NM_011427 Q4FK48 Q4FK48_MOUSE Snai1 uc008nzy.1 uc008nzy.2 uc008nzy.3 uc008nzy.4 negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding osteoblast differentiation epithelial to mesenchymal transition nucleic acid binding nucleus pericentric heterochromatin cytoplasm cytosol positive regulation of epithelial to mesenchymal transition negative regulation of vitamin D biosynthetic process kinase binding positive regulation of cell migration negative regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of transcription, DNA-templated E-box binding negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of bicellular tight junction assembly uc008nzy.1 uc008nzy.2 uc008nzy.3 uc008nzy.4 
ENSMUST00000052650.4 Hoxb8 ENSMUST00000052650.4 homeobox B8 (from RefSeq NM_010461.2) ENSMUST00000052650.1 ENSMUST00000052650.2 ENSMUST00000052650.3 HXB8_MOUSE Hox-2.4 Hoxb-8 NM_010461 P09632 uc007lbq.1 uc007lbq.2 uc007lbq.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Forms a DNA-binding heterodimer with transcription factor PBX1. P09632; P41778: Pbx1; NbExp=4; IntAct=EBI-925374, EBI-6996259; Nucleus. Belongs to the Antp homeobox family. negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development grooming behavior adult locomotory behavior anterior/posterior pattern specification sensory perception of pain dorsal spinal cord development sequence-specific DNA binding negative regulation of myeloid cell differentiation embryonic skeletal system morphogenesis skeletal system morphogenesis uc007lbq.1 uc007lbq.2 uc007lbq.3 
ENSMUST00000052652.7 Rdh9 ENSMUST00000052652.7 retinol dehydrogenase 9 (from RefSeq NM_153133.2) ENSMUST00000052652.1 ENSMUST00000052652.2 ENSMUST00000052652.3 ENSMUST00000052652.4 ENSMUST00000052652.5 ENSMUST00000052652.6 NM_153133 Q8K5C8 Q8K5C8_MOUSE Rdh9 uc007hkp.1 uc007hkp.2 Belongs to the short-chain dehydrogenases/reductases (SDR) family. retinol dehydrogenase activity endoplasmic reticulum membrane oxidoreductase activity integral component of organelle membrane 9-cis-retinoic acid biosynthetic process intracellular membrane-bounded organelle androsterone dehydrogenase activity androstan-3-alpha,17-beta-diol dehydrogenase activity oxidation-reduction process uc007hkp.1 uc007hkp.2 
ENSMUST00000052670.11 Amer3 ENSMUST00000052670.11 APC membrane recruitment 3 (from RefSeq NM_213727.2) AMER3_MOUSE ENSMUST00000052670.1 ENSMUST00000052670.10 ENSMUST00000052670.2 ENSMUST00000052670.3 ENSMUST00000052670.4 ENSMUST00000052670.5 ENSMUST00000052670.6 ENSMUST00000052670.7 ENSMUST00000052670.8 ENSMUST00000052670.9 Fam123c NM_213727 Q6NS69 Q8BS82 uc011wjc.1 uc011wjc.2 uc011wjc.3 Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). Cell membrane ; Peripheral membrane protein Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. Belongs to the Amer family. phosphatidylinositol-4,5-bisphosphate binding plasma membrane beta-catenin binding lipid binding membrane Wnt signaling pathway regulation of canonical Wnt signaling pathway uc011wjc.1 uc011wjc.2 uc011wjc.3 
ENSMUST00000052678.9 Flnb ENSMUST00000052678.9 filamin, beta, transcript variant 2 (from RefSeq NM_134080.1) E9QNV9 ENSMUST00000052678.1 ENSMUST00000052678.2 ENSMUST00000052678.3 ENSMUST00000052678.4 ENSMUST00000052678.5 ENSMUST00000052678.6 ENSMUST00000052678.7 ENSMUST00000052678.8 FLNB_MOUSE NM_134080 Q80X90 Q8VHX4 Q8VHX7 Q99KY3 uc007sel.1 uc007sel.2 uc007sel.3 uc007sel.4 Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton (By similarity). Homodimer. Interacts with FLNA, FLNC, INPPL1, ITGB1A, ITGB1D, ITGB3, ITGB6, MYOT, MYOZ1, PSEN1 and PSEN2 (By similarity). Interacts with MICALL2. Interacts with RFLNA and RFLNB (PubMed:21709252, PubMed:24436304). Interacts with ASB2 isoform 1; the interaction targets FLNB for proteasomal degradation (PubMed:26343497). Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber Cytoplasm, myofibril, sarcomere, Z line Expressed in hippocampus, cortex, cerebellar Purkinje cells and granule cell layers. Expressed within the ventricular, periventricular and subventricular zones at 12.5 dpc; olfactory epithelium, radial glial fibers, cortical plate and lateral ventricles at 16 dpc; in a lesser degree in lung, renal cortices and alimentary tract. Comprised of a NH2-terminal actin-binding domain, 24 internally homologous repeats and two hinge regions. Repeat 24 and the second hinge domain are important for dimer formation. The first hinge region prevents binding to ITGA and ITGB subunits (By similarity). ISGylation prevents ability to interact with the upstream activators of the JNK cascade and inhibits IFNA-induced JNK signaling. Ubiquitination by a SCF-like complex containing ASB2 isoform 1 leads to proteasomal degradation which promotes muscle differentiation. Belongs to the filamin family. stress fiber keratinocyte development epithelial cell morphogenesis actin binding protein binding nucleus cytoplasm cytosol cytoskeleton plasma membrane brush border focal adhesion cell cortex skeletal muscle tissue development Z disc actin cytoskeleton organization cell differentiation identical protein binding neuron projection neuronal cell body phagocytic vesicle cellular response to interferon-gamma uc007sel.1 uc007sel.2 uc007sel.3 uc007sel.4 
ENSMUST00000052686.4 H2ax ENSMUST00000052686.4 H2A.X variant histone (from RefSeq NM_010436.2) ENSMUST00000052686.1 ENSMUST00000052686.2 ENSMUST00000052686.3 H2AX_MOUSE H2a.x H2afx H2ax Hist5-2ax NM_010436 P27661 uc009pcy.1 uc009pcy.2 uc009pcy.3 uc009pcy.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC010336.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 25731851 ##RefSeq-Attributes-END## Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with numerous proteins required for DNA damage signaling and repair when phosphorylated on Ser-140. These include MDC1, BRCA1 and the MRN complex, composed of MRE11, RAD50, and NBN. Interaction with the MRN complex is mediated at least in part by NBN. Also interacts with DHX9/NDHII when phosphorylated on Ser-140 and MCPH1 when phosphorylated at Ser-140 or Tyr-143. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with WRAP53/TCAB1 (By similarity). Interacts with TP53BP1 (PubMed:12697768). Interacts with HDGFL2 (By similarity). P27661; Q9Z0X1: Aifm1; NbExp=3; IntAct=EBI-495621, EBI-773597; P27661; Q80V62: Fancd2; NbExp=2; IntAct=EBI-495621, EBI-7268304; Nucleus romosome Most abundant in testis, thymus and spleen. Synthesized in G1 as well as in S-phase. The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family. Phosphorylated on Ser-140 (to form gamma-H2AX or H2AX139ph) in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents, by stalled replication forks, by meiotic recombination events and during immunoglobulin class switching in lymphocytes. Phosphorylation can extend up to several thousand nucleosomes from the actual site of the DSB and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Widespread phosphorylation may also serve to amplify the damage signal or aid repair of persistent lesions. Phosphorylation of Ser-140 (H2AX139ph) in response to ionizing radiation is mediated by both ATM and PRKDC while defects in DNA replication induce Ser-140 phosphorylation (H2AX139ph) subsequent to activation of ATR and PRKDC. Dephosphorylation of Ser-140 by PP2A is required for DNA DSB repair. In meiosis, Ser-140 phosphorylation (H2AX139ph) first occurs at synaptonemal complexes during leptotene and is an ATM-dependent response to the formation of programmed DSBs by SPO11. Ser-140 phosphorylation (H2AX139ph) subsequently occurs at unsynapsed regions of both autosomes and the XY bivalent during zygotene and is ATR- and BRCA1-dependent. Ser-140 phosphorylation (H2AX139ph) may also be required for transcriptional repression of unsynapsed chromatin and meiotic sex chromosome inactivation (MSCI), whereby the X and Y chromosomes condense in pachytene to form the heterochromatic XY-body. During immunoglobulin class switch recombination in lymphocytes, Ser-140 phosphorylation (H2AX139ph) at sites of DNA-recombination requires the activation-induced cytidine deaminase AICDA. Phosphorylation at Tyr-143 (H2AXY142ph) by BAZ1B/WSTF determines the relative recruitment of either DNA repair or pro- apoptotic factors. Phosphorylation at Tyr-143 (H2AXY142ph) favors the recruitment of APBB1/FE65 and pro-apoptosis factors such as MAPK8/JNK1, triggering apoptosis. In contrast, dephosphorylation of Tyr-143 by EYA proteins (EYA1, EYA2, EYA3 or EYA4) favors the recruitment of MDC1- containing DNA repair complexes to the tail of phosphorylated Ser-140 (H2AX139ph). Monoubiquitination of Lys-120 (H2AXK119ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events (By similarity). Acetylation at Lys-6 (H2AXK5ac) by KAT5 component of the NuA4 histone acetyltransferase complex promotes NBN/NBS1 assembly at the sites of DNA damage (By similarity). Acetylation at Lys-37 increases in S and G2 phases (PubMed:20488183, PubMed:7217105). This modification has been proposed to be important for DNA double-strand break repair (PubMed:20488183). Haploinsufficient for the suppression of genomic instability. This phenotype is further exacerbated in the absence of TP53. Belongs to the histone H2A family. double-strand break repair via homologous recombination chromosome, telomeric region chromatin nucleosome nuclear chromatin condensed nuclear chromosome male germ cell nucleus XY body DNA binding damaged DNA binding protein binding nucleus nucleoplasm replication fork chromosome centrosome DNA repair DNA recombination chromatin organization cellular response to DNA damage stimulus cell cycle spermatogenesis nuclear speck enzyme binding cerebral cortex development site of double-strand break histone binding protein heterodimerization activity meiotic cell cycle cellular response to gamma radiation cellular senescence DNA damage checkpoint uc009pcy.1 uc009pcy.2 uc009pcy.3 uc009pcy.4 
ENSMUST00000052690.13 Prss54 ENSMUST00000052690.13 serine protease 54 (from RefSeq NM_001310539.1) 4931432M23Rik A6H685 A6H685_MOUSE ENSMUST00000052690.1 ENSMUST00000052690.10 ENSMUST00000052690.11 ENSMUST00000052690.12 ENSMUST00000052690.2 ENSMUST00000052690.3 ENSMUST00000052690.4 ENSMUST00000052690.5 ENSMUST00000052690.6 ENSMUST00000052690.7 ENSMUST00000052690.8 ENSMUST00000052690.9 NM_001310539 Prss54 uc009myp.1 uc009myp.2 uc009myp.3 uc009myp.4 serine-type endopeptidase activity proteolysis uc009myp.1 uc009myp.2 uc009myp.3 uc009myp.4 
ENSMUST00000052691.9 1600012H06Rik ENSMUST00000052691.9 RIKEN cDNA 1600012H06 gene, transcript variant 2 (from RefSeq NM_026451.2) CF120_MOUSE ENSMUST00000052691.1 ENSMUST00000052691.2 ENSMUST00000052691.3 ENSMUST00000052691.4 ENSMUST00000052691.5 ENSMUST00000052691.6 ENSMUST00000052691.7 ENSMUST00000052691.8 NM_026451 Q80ST2 Q8CEI9 Q9CU86 Q9DAY5 uc008ang.1 uc008ang.2 uc008ang.3 May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes. Secreted Note=Secreted by hepatocytes. Belongs to the UPF0669 family. Sequence=AAH43303.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH43449.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB30667.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC25722.1; Type=Frameshift; Evidence=; molecular_function extracellular region apoptotic process biological_process uc008ang.1 uc008ang.2 uc008ang.3 
ENSMUST00000052700.6 Ffar1 ENSMUST00000052700.6 free fatty acid receptor 1 (from RefSeq NM_194057.3) A2RS88 ENSMUST00000052700.1 ENSMUST00000052700.2 ENSMUST00000052700.3 ENSMUST00000052700.4 ENSMUST00000052700.5 FFAR1_MOUSE Gpr40 NM_194057 Q76JU9 Q8K3T5 uc009ggq.1 uc009ggq.2 uc009ggq.3 G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (PubMed:23335512). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. Is also activated by synthetic agonists, such as AM-8182, AM-6331 and TAK-875 (fasiglifam). AM-8182 is a full agonist, while AM-6331 and TAK-875 (fasiglifam) are partial agonists that potentiate the activity of the endogenous ligands, such as alpha- linolenic acid and gamma-linolenic acid. Cell membrane ulti-pass membrane protein Expressed in pancreatic islet beta cells (at protein level) (PubMed:16044321). Expressed in pancreatic islet beta cells. No visible phenotype at birth and during the following six weeks. Male mice tend to develop a slightly decreased glucose tolerance after 13 weeks of age, but this is not observed with female mice. Insulin secretion in response to glucose is unchanged in mutant mice, but it is not potentiated by fatty acids, contrary to what is observed with wild-type mice. On the other hand, wild-type and mutant mice display the same inhibition of the first phase of glucose- stimulated insulin secretion after prolonged exposure to fatty acids or exposure to a high-fat diet (PubMed:17395749, PubMed:18559658). Compared to wild-type, mutant mice that are kept on a high-fat diet display a decrease of the second phase of glucose-stimulated insulin secretion (PubMed:18559658). Mutant mice do not display increased secretion of glucagon-like peptide 1 (GLP-1) in response to oral absorption of corn oil and display slightly increased blood glucose levels after oral absorption of corn oil (PubMed:23403053). Besides, mutant mice display decreased bone density (PubMed:23335512). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity fatty acid binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway lipid binding positive regulation of calcium ion transport into cytosol membrane integral component of membrane insulin secretion positive regulation of insulin secretion glucose homeostasis bioactive lipid receptor activity positive regulation of calcium ion transport response to fatty acid uc009ggq.1 uc009ggq.2 uc009ggq.3 
ENSMUST00000052702.7 BC049715 ENSMUST00000052702.7 cDNA sequence BC049715 (from RefSeq NM_178776.3) CL060_MOUSE ENSMUST00000052702.1 ENSMUST00000052702.2 ENSMUST00000052702.3 ENSMUST00000052702.4 ENSMUST00000052702.5 ENSMUST00000052702.6 NM_178776 Q810N5 Q8C8R6 uc009emi.1 uc009emi.2 uc009emi.3 uc009emi.4 uc009emi.5 molecular_function cellular_component biological_process uc009emi.1 uc009emi.2 uc009emi.3 uc009emi.4 uc009emi.5 
ENSMUST00000052708.7 Ckap2l ENSMUST00000052708.7 cytoskeleton associated protein 2-like (from RefSeq NM_181589.3) CKP2L_MOUSE ENSMUST00000052708.1 ENSMUST00000052708.2 ENSMUST00000052708.3 ENSMUST00000052708.4 ENSMUST00000052708.5 ENSMUST00000052708.6 NM_181589 Q3U5A3 Q7TS74 Q8K264 U6C6D6 uc008mho.1 uc008mho.2 uc008mho.3 Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells. Cytoplasm, cytoskeleton, spindle pole Note=Uniformly distributed along each microtubule bundle of spindles in addition to centrioles during mitosis, expression promptly diminishes at interphase. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TS74-1; Sequence=Displayed; Name=2; IsoId=Q7TS74-2; Sequence=VSP_032221, VSP_032222; Highly expressed in regions of active neurogenesis and neural stem/progenitor cells (NSPCs), both embryonic and adult, not detected in lung, liver, kidney, heart, and skeletal muscle. At 10.5 dpc, strongly expressed in the neural progenitor cells throughout the neural tube and in the myotome. Expression is significantly lower in connective tissues compared to neural tube, but can be detected at the mitotic spindles of dividing mesenchymal cells loosely distributed in the developing limb bud. In an 12.5 dpc forelimb bud, detected in the dividing cells at the boundary region between protruding cartilage and surrounding mesenchyme (at protein level). The KEN box is required for the association with the APC/C-Cdh1 complex, ubiquitination and degradation. Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C). Belongs to the CKAP2 family. spindle pole molecular_function cytoplasm centrosome cytosol cytoskeleton biological_process mitotic spindle uc008mho.1 uc008mho.2 uc008mho.3 
ENSMUST00000052712.6 Tgs1 ENSMUST00000052712.6 trimethylguanosine synthase 1 (from RefSeq NM_054089.4) A2AJF7 ENSMUST00000052712.1 ENSMUST00000052712.2 ENSMUST00000052712.3 ENSMUST00000052712.4 ENSMUST00000052712.5 NM_054089 Ncoa6ip Pimt Q6DI60 Q6PEA7 Q8R0W9 Q923W1 TGS1_MOUSE uc008rwi.1 uc008rwi.2 uc008rwi.3 uc008rwi.4 uc008rwi.5 Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation (By similarity). Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'- triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:67620, Rhea:RHEA-COMP:17167, Rhea:RHEA- COMP:17315, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, ChEBI:CHEBI:172880; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67621; Evidence=; Reaction=a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)- ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:67624, Rhea:RHEA-COMP:17171, Rhea:RHEA-COMP:17315, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:167623, ChEBI:CHEBI:172880; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67625; Evidence=; May form homooligomers. Interacts with CREBBP/CBP, EED/WAIT1, EP300/P300, NCOA6/PRIP, PPARBP/PBP and SMN (By similarity). Cytoplasm Nucleus, Cajal body Nucleus, nucleolus Ubiquitously expressed. Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. RNA methylation nucleus nucleolus cytoplasm cytosol methyltransferase activity 7-methylguanosine RNA capping Cajal body transferase activity methylation 7-methylguanosine cap hypermethylation RNA trimethylguanosine synthase activity uc008rwi.1 uc008rwi.2 uc008rwi.3 uc008rwi.4 uc008rwi.5 
ENSMUST00000052716.8 Zfp759 ENSMUST00000052716.8 zinc finger protein 759 (from RefSeq NM_172392.3) BC028265 ENSMUST00000052716.1 ENSMUST00000052716.2 ENSMUST00000052716.3 ENSMUST00000052716.4 ENSMUST00000052716.5 ENSMUST00000052716.6 ENSMUST00000052716.7 NM_172392 Q7M6X3 Q7M6X3_MOUSE Rslcan8 Zfp759 uc007rah.1 uc007rah.2 May be involved in transcriptional regulation. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated biological_process metal ion binding uc007rah.1 uc007rah.2 
ENSMUST00000052718.5 Kcna3 ENSMUST00000052718.5 potassium voltage-gated channel, shaker-related subfamily, member 3 (from RefSeq NM_008418.3) A3KMM2 ENSMUST00000052718.1 ENSMUST00000052718.2 ENSMUST00000052718.3 ENSMUST00000052718.4 KCNA3_MOUSE NM_008418 P16390 uc008qwp.1 uc008qwp.2 uc008qwp.3 uc008qwp.4 Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG4 (By similarity). Cell membrane ; Multi-pass membrane protein. The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. N-glycosylation promotes the cell surface expression. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity plasma membrane integral component of plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex outward rectifier potassium channel activity membrane integral component of membrane axon regulation of ion transmembrane transport calyx of Held membrane raft protein homooligomerization transmembrane transport potassium ion transmembrane transport glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane uc008qwp.1 uc008qwp.2 uc008qwp.3 uc008qwp.4 
ENSMUST00000052724.5 Ucn2 ENSMUST00000052724.5 urocortin 2 (from RefSeq NM_145077.1) ENSMUST00000052724.1 ENSMUST00000052724.2 ENSMUST00000052724.3 ENSMUST00000052724.4 F8WIL4 NM_145077 Q99ML8 UCN2_MOUSE uc012hax.1 uc012hax.2 uc012hax.3 This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit increased insulin sensitivity and were protected against fat-induced insulin resistance. In addition, female mice lacking the encoded protein exhibit a significant increase in the basal daily rhythms of adrenocorticotropic hormone and corticosterone, and a significant decrease in fluid intake and depressive-like behavior. [provided by RefSeq, Sep 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity). Binds with high affinity to CRF receptors 2-alpha and 2-beta. Secreted Glycosylated. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. G-protein coupled receptor binding hormone activity protein binding extracellular region extracellular space adenylate cyclase-activating G-protein coupled receptor signaling pathway digestion cell proliferation hormone-mediated signaling pathway negative regulation of gene expression cellular response to nutrient levels negative regulation of luteinizing hormone secretion hormone binding negative regulation of follicle-stimulating hormone secretion corticotropin-releasing hormone receptor binding corticotropin-releasing hormone receptor 2 binding uc012hax.1 uc012hax.2 uc012hax.3 
ENSMUST00000052725.15 Sc5d ENSMUST00000052725.15 sterol-C5-desaturase (from RefSeq NM_172769.2) ENSMUST00000052725.1 ENSMUST00000052725.10 ENSMUST00000052725.11 ENSMUST00000052725.12 ENSMUST00000052725.13 ENSMUST00000052725.14 ENSMUST00000052725.2 ENSMUST00000052725.3 ENSMUST00000052725.4 ENSMUST00000052725.5 ENSMUST00000052725.6 ENSMUST00000052725.7 ENSMUST00000052725.8 ENSMUST00000052725.9 NM_172769 O88822 Q8BGI0 SC5D_MOUSE Sc5dl uc029wyj.1 uc029wyj.2 uc029wyj.3 Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol in cholesterol biosynthesis. Reaction=a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:54320, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:138130, ChEBI:CHEBI:138131; EC=1.14.19.20; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54321; Evidence=; Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 = 7- dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:46556, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17168, ChEBI:CHEBI:17759, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.14.19.20; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46557; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein The histidine box domains may contain the active site and/or be involved in metal ion binding. Belongs to the sterol desaturase family. C-5 sterol desaturase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process steroid metabolic process lipid biosynthetic process membrane integral component of membrane sterol biosynthetic process oxidoreductase activity cholesterol biosynthetic process via lathosterol intracellular membrane-bounded organelle oxidation-reduction process uc029wyj.1 uc029wyj.2 uc029wyj.3 
ENSMUST00000052730.3 Mrgprb2 ENSMUST00000052730.3 MAS-related GPR, member B2 (from RefSeq NM_175531.4) ENSMUST00000052730.1 ENSMUST00000052730.2 Mgrg14 Mrgprb2 NM_175531 W8W3G3 W8W3G3_MOUSE uc009hat.1 uc009hat.2 uc009hat.3 uc009hat.4 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009hat.1 uc009hat.2 uc009hat.3 uc009hat.4 
ENSMUST00000052740.14 Tcaim ENSMUST00000052740.14 T cell activation inhibitor, mitochondrial, transcript variant 8 (from RefSeq NM_001408940.1) D9Ertd402e ENSMUST00000052740.1 ENSMUST00000052740.10 ENSMUST00000052740.11 ENSMUST00000052740.12 ENSMUST00000052740.13 ENSMUST00000052740.2 ENSMUST00000052740.3 ENSMUST00000052740.4 ENSMUST00000052740.5 ENSMUST00000052740.6 ENSMUST00000052740.7 ENSMUST00000052740.8 ENSMUST00000052740.9 G3X983 G3X983_MOUSE NM_001408940 Tcaim uc009sfc.1 uc009sfc.2 uc009sfc.3 uc009sfc.4 mitochondrion uc009sfc.1 uc009sfc.2 uc009sfc.3 uc009sfc.4 
ENSMUST00000052747.4 Nhlrc1 ENSMUST00000052747.4 NHL repeat containing 1 (from RefSeq NM_175340.4) ENSMUST00000052747.1 ENSMUST00000052747.2 ENSMUST00000052747.3 Epm2b NHLC1_MOUSE NM_175340 Q8BR37 uc007qhp.1 uc007qhp.2 uc007qhp.3 E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin- dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with AGL. Interacts (via the NHL repeats) with EPM2A/laforin (By similarity). Forms a complex with EPM2A/laforin and HSP70. Interacts with PRDM8 (By similarity). Endoplasmic reticulum Nucleus Note=Localizes at the endoplasmic reticulum and, to a lesser extent, in the nucleus. The RING domain is essential for ubiquitin E3 ligase activity. Significant impairment of motor activity, coordination and balance; spontaneous myoclonic seizures; and decreases in episodic memory. 3- and 6-month old mice contain numerous large insoluble aggregates composed mainly of polyglucosans called Lafora bodies (LBs) in skeletal muscle, liver, heart and brain. Glycogen levels are increased 1.6-fold and 1.2-fold respectively in skeletal muscle and liver of 6-month old mice. Glycogen phosphate levels are increased 1.5-fold in skeletal muscle and liver of 6-month old mice. In brain extracts from 1-, 3- and 12-month old mice, total amounts of Epm2b/laforin protein (but not mRNA) are increased. In brain and embryonic fibroblast cells, levels of the autophagy marker Map1lc3b/LC3-II are reduced. In the brain, levels of the autophagy dysfunction marker Sqstm1/p62 are increased. protein polyubiquitination regulation of protein phosphorylation ubiquitin-protein transferase activity protein binding nucleus endoplasmic reticulum glycogen metabolic process glycogen biosynthetic process autophagy regulation of gene expression protein ubiquitination transferase activity regulation of protein ubiquitination positive regulation of protein ubiquitination response to endoplasmic reticulum stress proteasome-mediated ubiquitin-dependent protein catabolic process cellular macromolecule metabolic process regulation of protein kinase activity metal ion binding perinuclear region of cytoplasm ubiquitin protein ligase activity regulation of protein localization to plasma membrane uc007qhp.1 uc007qhp.2 uc007qhp.3 
ENSMUST00000052761.9 Idh3g ENSMUST00000052761.9 isocitrate dehydrogenase 3 (NAD+), gamma, transcript variant 1 (from RefSeq NM_008323.2) ENSMUST00000052761.1 ENSMUST00000052761.2 ENSMUST00000052761.3 ENSMUST00000052761.4 ENSMUST00000052761.5 ENSMUST00000052761.6 ENSMUST00000052761.7 ENSMUST00000052761.8 Idh3g NM_008323 Q3TGZ3 Q3TGZ3_MOUSE uc009tmp.1 uc009tmp.2 Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer. Mitochondrion Belongs to the isocitrate and isopropylmalate dehydrogenases family. magnesium ion binding isocitrate dehydrogenase (NAD+) activity nucleoplasm nucleolus mitochondrion tricarboxylic acid cycle oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor NAD binding oxidation-reduction process uc009tmp.1 uc009tmp.2 
ENSMUST00000052774.8 Tyw3 ENSMUST00000052774.8 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae), transcript variant 1 (from RefSeq NM_172474.6) ENSMUST00000052774.1 ENSMUST00000052774.2 ENSMUST00000052774.3 ENSMUST00000052774.4 ENSMUST00000052774.5 ENSMUST00000052774.6 ENSMUST00000052774.7 NM_172474 Q8BSA9 Q8BSX2 TYW3_MOUSE uc008ruo.1 uc008ruo.2 uc008ruo.3 uc008ruo.4 Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). Reaction=4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3- carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:36635, Rhea:RHEA-COMP:10378, Rhea:RHEA- COMP:10379, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73543, ChEBI:CHEBI:73550; EC=2.1.1.282; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. Belongs to the TYW3 family. Sequence=BAC26913.1; Type=Erroneous initiation; Evidence=; cytoplasm tRNA processing methyltransferase activity tRNA methyltransferase activity transferase activity tRNA methylation wybutosine biosynthetic process methylation uc008ruo.1 uc008ruo.2 uc008ruo.3 uc008ruo.4 
ENSMUST00000052776.4 H2bc1 ENSMUST00000052776.4 H2B clustered histone 1 (from RefSeq NM_175663.2) ENSMUST00000052776.1 ENSMUST00000052776.2 ENSMUST00000052776.3 H2B1A_MOUSE H2bc1 Hist1h2ba NM_175663 P70696 Q5NCL9 Th2b uc007pvi.1 uc007pvi.2 uc007pvi.3 uc007pvi.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (PubMed:23884607, PubMed:28366643). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (PubMed:23884607). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (PubMed:23884607). Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers (PubMed:23884607). Interacts with H2AB1; preferentially dimerizes with H2AB1 to form nucleosomes (PubMed:28366643). Nucleus Chromosome Mainly expressed in testis, and the corresponding protein is also present in mature sperm. Also present in metaphase oocytes (at protein level). Accumulates at 10 day postpartum (dpp), when pre- leptotene/leptotene spermatocytes first appear and when H2B expression shows a drastic decrease. Replaces H2B by 18 dpp in spermatocytes. Also present in metaphase oocytes and in the female pronucleus at fertilization and is also rapidly incorporated into the male pronucleus. Monoubiquitination at Lys-36 by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination of Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Acetylated during spermatogenesis. Acetylated form is most abundant in spermatogonia compared to spermatocytes and round spermatids (By similarity). Phosphorylated at Thr-117 in spermatogonia, spermatocytes and round spermatids. Methylated at Lys-118 in spermatogonia, spermatocytes and round spermatids. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome DNA packaging chromatin organization nucleosome assembly nucleosome disassembly inflammatory response extrinsic component of plasma membrane plasminogen activation spermatogenesis, exchange of chromosomal proteins histone binding DNA packaging complex protein heterodimerization activity positive regulation of binding mononuclear cell migration uc007pvi.1 uc007pvi.2 uc007pvi.3 uc007pvi.4 
ENSMUST00000052778.10 Zbtb12 ENSMUST00000052778.10 zinc finger and BTB domain containing 12, transcript variant 1 (from RefSeq NM_198886.4) ENSMUST00000052778.1 ENSMUST00000052778.2 ENSMUST00000052778.3 ENSMUST00000052778.4 ENSMUST00000052778.5 ENSMUST00000052778.6 ENSMUST00000052778.7 ENSMUST00000052778.8 ENSMUST00000052778.9 H2-Bf NM_198886 Q9Z150 Q9Z150_MOUSE Zbtb12 uc008cea.1 uc008cea.2 uc008cea.3 negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus uc008cea.1 uc008cea.2 uc008cea.3 
ENSMUST00000052798.14 Ptges3 ENSMUST00000052798.14 prostaglandin E synthase 3 (from RefSeq NM_019766.4) ENSMUST00000052798.1 ENSMUST00000052798.10 ENSMUST00000052798.11 ENSMUST00000052798.12 ENSMUST00000052798.13 ENSMUST00000052798.2 ENSMUST00000052798.3 ENSMUST00000052798.4 ENSMUST00000052798.5 ENSMUST00000052798.6 ENSMUST00000052798.7 ENSMUST00000052798.8 ENSMUST00000052798.9 NM_019766 Q542V4 Q9D7V0 Q9R0Q7 Q9WV83 Sid3177 TEBP_MOUSE Tebp uc007hld.1 uc007hld.2 uc007hld.3 Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. Reaction=prostaglandin H2 = prostaglandin E2; Xref=Rhea:RHEA:12893, ChEBI:CHEBI:57405, ChEBI:CHEBI:606564; EC=5.3.99.3; Evidence=; Lipid metabolism; prostaglandin biosynthesis. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2. Binds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation. Interacts with HSP90AA1, FLCN, FNIP1 and FNIP2. Cytoplasm Expressed in testis, kidney, bladder and ovary. Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation. Belongs to the p23/wos2 family. prostaglandin biosynthetic process p53 binding telomerase activity cellular_component nucleus nucleoplasm telomerase holoenzyme complex cytoplasm cytosol actin filament glycogen biosynthetic process protein folding lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process telomere maintenance via telomerase cell proliferation positive regulation of gene expression isomerase activity sensory perception of pain enzyme binding macromolecular complex positive regulation of phosphorylation glucocorticoid receptor signaling pathway neuron projection neuronal cell body intracellular membrane-bounded organelle skin development perinuclear region of cytoplasm prostaglandin-E synthase activity protein stabilization unfolded protein binding chaperone mediated protein folding requiring cofactor chaperone binding chaperone-mediated protein complex assembly Hsp90 protein binding positive regulation of telomerase activity lung saccule development negative regulation of cell death DNA polymerase binding telomerase holoenzyme complex assembly uc007hld.1 uc007hld.2 uc007hld.3 
ENSMUST00000052825.7 Ufsp1 ENSMUST00000052825.7 UFM1-specific peptidase 1 (from RefSeq NM_027356.2) D5Ertd655e ENSMUST00000052825.1 ENSMUST00000052825.2 ENSMUST00000052825.3 ENSMUST00000052825.4 ENSMUST00000052825.5 ENSMUST00000052825.6 NM_027356 Q9CZP0 UFSP1_MOUSE uc009abz.1 uc009abz.2 uc009abz.3 Thiol-dependent isopeptidase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Widely expressed. Expressed at higher level in brain, heart, kidney and skeletal muscle. Belongs to the peptidase C78 family. proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity thiolester hydrolase activity UFM1 hydrolase activity uc009abz.1 uc009abz.2 uc009abz.3 
ENSMUST00000052827.6 Ppp1r17 ENSMUST00000052827.6 protein phosphatase 1, regulatory subunit 17 (from RefSeq NM_011153.4) ENSMUST00000052827.1 ENSMUST00000052827.2 ENSMUST00000052827.3 ENSMUST00000052827.4 ENSMUST00000052827.5 Gsbs NM_011153 PPR17_MOUSE Q9Z2E4 uc009cay.1 uc009cay.2 uc009cay.3 Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes. Expressed in Purkinje cells of the cerebellum, hippocampus, pons, medulla and eye. Substrate for cGMP-dependent protein kinase (By similarity). Phosphorylation of Thr-72 and Thr-123 is required for its phosphatase activity. Phosphorylated by PRKG1 isoform alpha. protein phosphatase inhibitor activity protein serine/threonine phosphatase inhibitor activity nucleoplasm cytosol regulation of phosphatase activity phosphatase inhibitor activity negative regulation of phosphoprotein phosphatase activity negative regulation of catalytic activity uc009cay.1 uc009cay.2 uc009cay.3 
ENSMUST00000052832.6 Micos13 ENSMUST00000052832.6 mitochondrial contact site and cristae organizing system subunit 13 (from RefSeq NM_153152.4) ENSMUST00000052832.1 ENSMUST00000052832.2 ENSMUST00000052832.3 ENSMUST00000052832.4 ENSMUST00000052832.5 MIC13_MOUSE Mic13 NM_153152 Q8R404 Qil1 uc008dcl.1 uc008dcl.2 Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex. Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, MICOS13/MIC13, APOOL/MIC27 and IMMT/MIC60. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Mitochondrion inner membrane ; Single-pass membrane protein Note=Enriched at crista junctions. Belongs to the MICOS complex subunit Mic13 family. molecular_function nucleoplasm mitochondrion mitochondrial inner membrane membrane integral component of membrane cristae formation mitochondrial crista junction MICOS complex uc008dcl.1 uc008dcl.2 
ENSMUST00000052835.9 Fam167b ENSMUST00000052835.9 family with sequence similarity 167, member B (from RefSeq NM_182783.2) ENSMUST00000052835.1 ENSMUST00000052835.2 ENSMUST00000052835.3 ENSMUST00000052835.4 ENSMUST00000052835.5 ENSMUST00000052835.6 ENSMUST00000052835.7 ENSMUST00000052835.8 F167B_MOUSE NM_182783 P17257 Q3UNY6 Sec uc008uxl.1 uc008uxl.2 uc008uxl.3 uc008uxl.4 Belongs to the FAM167 (SEC) family. Was originally thought to originate from human. Sequence=CAA36502.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc008uxl.1 uc008uxl.2 uc008uxl.3 uc008uxl.4 
ENSMUST00000052837.9 Ar ENSMUST00000052837.9 androgen receptor (from RefSeq NM_013476.4) ANDR_MOUSE ENSMUST00000052837.1 ENSMUST00000052837.2 ENSMUST00000052837.3 ENSMUST00000052837.4 ENSMUST00000052837.5 ENSMUST00000052837.6 ENSMUST00000052837.7 ENSMUST00000052837.8 NM_013476 Nr3c4 P19091 uc009tuv.1 uc009tuv.2 uc009tuv.3 uc009tuv.4 This gene encodes a nuclear hormone receptor containing zinc finger and DNA-binding domains. The encoded protein is a key regulator of signalling by androgens, a class of steroid hormones involved in male reproductive development. The protein responds to hormone signalling by translocating to the nucleus, forming dimers, and binding to androgen response elements (AREs) in the promoters of target genes, which are subsequently transcriptionally activated. Activity of this protein is negatively regulated by nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as Dax1). Mutations in this gene result in feminized genitals and infertility in male animals. Loss of function in female animals also causes problems in reproductive development and function. [provided by RefSeq, May 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.53046.1, SRR1660815.156156.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PQBP1, RANBP9, SPDEF, SRA1, TGFB1I1, ZNF318 and RREB1. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR- mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with RBAK. Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. Interacts with HIP1 (via coiled coil domain). Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts with MACROD1 (via macro domain) (By similarity). Interacts (via ligand- binding domain) with TRIM68. Interacts with TNK2. Interacts with USP26. Interacts with RNF6. Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with RACK1. Interacts with RANBP10; this interaction enhances hormone-induced AR transcriptional activity. Interacts with PRPF6 in a hormone-independent way; this interaction enhances hormone-induced AR transcriptional activity. Interacts with STK4/MST1. Interacts with ZIPK/DAPK3. Interacts with LPXN. Interacts with MAK. Part of a complex containing AR, MAK and NCOA3. Interacts with CRY1 (PubMed:22170608, PubMed:28751364). Interacts with CCAR1 and GATA2 (By similarity). Interacts with BUD31 (By similarity). Interacts with ARID4A (PubMed:23487765). Interacts with ARID4B (PubMed:23487765). Interacts (via NR LBD domain) with ZBTB7A; the interaction is direct and androgen-dependent (By similarity). Interacts with NCOR1 (By similarity). Interacts with NCOR2 (By similarity). Interacts with CRY2 in a ligand-dependent manner (PubMed:28751364). P19091; O89110: Casp8; NbExp=2; IntAct=EBI-1776062, EBI-851690; Nucleus Cytoplasm Note=Detected at the promoter of target genes. Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins. Interaction with RANBP9 is mediated by both the N-terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain (By similarity). Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-514 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression (By similarity). Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity. Phosphorylation at Ser-61 by CDK9 regulates AR promoter selectivity and cell growth. Phosphorylation by PAK6 leads to AR-mediated transcription inhibition (By similarity). Sumoylated on Lys-381 (major) and Lys-500 (By similarity). Ubiquitinated. Deubiquitinated by USP26 (By similarity). 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity (By similarity). Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity). In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites. Transcriptional activity is enhanced by binding to RANBP9. Belongs to the nuclear hormone receptor family. NR3 subfamily. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor binding RNA polymerase II basal transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development regulation of systemic arterial blood pressure epithelial cell morphogenesis DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding steroid binding androgen binding protein binding nucleus cytoplasm plasma membrane transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter spermatogenesis single fertilization copulation beta-catenin binding male courtship behavior transcription factor binding zinc ion binding positive regulation of cell proliferation negative regulation of cell proliferation lipid binding male gonad development fertilization cellular process regulation of gene expression positive regulation of gene expression skeletal muscle hypertrophy nuclear speck reproductive behavior male somatic sex determination enzyme binding protein domain specific binding axon dendrite androgen receptor signaling pathway intracellular receptor signaling pathway ribonucleotide binding macromolecular complex positive regulation of intracellular estrogen receptor signaling pathway Leydig cell differentiation multicellular organism growth positive regulation of phosphorylation positive regulation of MAPK cascade sequence-specific DNA binding positive regulation of insulin-like growth factor receptor signaling pathway transcription regulatory region DNA binding positive regulation of cell differentiation negative regulation of integrin biosynthetic process positive regulation of integrin biosynthetic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase III promoter male sex differentiation metal ion binding reproductive structure development regulation of developmental growth animal organ formation male genitalia morphogenesis negative regulation of epithelial cell proliferation androgen receptor binding positive regulation of NF-kappaB transcription factor activity ATPase binding positive regulation of penile erection activation of prostate induction by androgen receptor signaling pathway morphogenesis of an epithelial fold lateral sprouting involved in mammary gland duct morphogenesis regulation of prostatic bud formation prostate gland growth prostate gland epithelium morphogenesis epithelial cell differentiation involved in prostate gland development tertiary branching involved in mammary gland duct morphogenesis mammary gland alveolus development positive regulation of epithelial cell proliferation involved in prostate gland development reproductive system development POU domain binding cellular response to steroid hormone stimulus cellular response to testosterone stimulus seminiferous tubule development regulation of protein localization to plasma membrane negative regulation of extrinsic apoptotic signaling pathway uc009tuv.1 uc009tuv.2 uc009tuv.3 uc009tuv.4 
ENSMUST00000052838.11 Mib1 ENSMUST00000052838.11 MIB E3 ubiquitin protein ligase 1, transcript variant 1 (from RefSeq NM_144860.3) Dip1 ENSMUST00000052838.1 ENSMUST00000052838.10 ENSMUST00000052838.2 ENSMUST00000052838.3 ENSMUST00000052838.4 ENSMUST00000052838.5 ENSMUST00000052838.6 ENSMUST00000052838.7 ENSMUST00000052838.8 ENSMUST00000052838.9 Kiaa1323 MIB1_MOUSE Mib NM_144860 Q5XK51 Q6IS57 Q6YI52 Q6ZPT8 Q80SY4 Q8BNR1 Q8C6W2 Q921Q1 uc008ebc.1 uc008ebc.2 uc008ebc.3 E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation (By similarity). Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with CEP131 and PCM1. Q80SY4; Q8IY22: CMIP; Xeno; NbExp=2; IntAct=EBI-645227, EBI-7689652; Q80SY4; Q803H8: wu:fa66c10; Xeno; NbExp=4; IntAct=EBI-645227, EBI-42472685; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cytoplasm. Cell membrane. Note=Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Localizes to the plasma membrane. Detected in all tissues tested. Present in embryo, embryonic stem cells, bladder, skeletal muscle, bladder, uterus, testis, stomach, colon, ileum, trachea, lung, aorta, kidney, spleen, liver and vas deferens (at protein level). Highly expressed in testis. Highly expressed both in embryos and adult tissues. In 9.5 dpc and 10.5 dpc embryos, it is expressed in the tail bud, limb buds and somites. Expressed in the same pattern than MIB2 in the skin and intestine at postnatal day 1 (P1) and in the hair follicle in the skin in the adult. Ubiquitinated; this modification is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Ubiquitinated; possibly via autoubiquitination. Sequence=AAH11287.1; Type=Erroneous initiation; Evidence=; Sequence=AAH69870.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence=; Sequence=AAN18022.1; Type=Erroneous initiation; Evidence=; Sequence=BAC38042.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence=; blood vessel development in utero embryonic development somitogenesis neural tube formation heart looping ubiquitin-protein transferase activity protein binding cytoplasm centrosome microtubule organizing center cytoskeleton plasma membrane endocytosis Notch signaling pathway heart development zinc ion binding postsynaptic density membrane protein ubiquitination transferase activity cytoplasmic vesicle negative regulation of neuron differentiation positive regulation of endocytosis metal ion binding uc008ebc.1 uc008ebc.2 uc008ebc.3 
ENSMUST00000052839.7 Efnb1 ENSMUST00000052839.7 ephrin B1 (from RefSeq NM_010110.5) ENSMUST00000052839.1 ENSMUST00000052839.2 ENSMUST00000052839.3 ENSMUST00000052839.4 ENSMUST00000052839.5 ENSMUST00000052839.6 Efnb1 NM_010110 Q544L9 Q544L9_MOUSE uc009tvi.1 uc009tvi.2 uc009tvi.3 uc009tvi.4 This gene encodes a membrane protein that acts as a ligand for Eph family receptors. Signalling occurs bidirectionally in both the cell containing the receptor and the cell expressing this protein. Activity of this protein is important in neuronal axon growth and other developmental processes. [provided by RefSeq, May 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK034996.1, BC018572.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Single- pass type I membrane protein Belongs to the ephrin family. Lacks conserved residue(s) required for the propagation of feature annotation. plasma membrane membrane integral component of membrane ephrin receptor binding ephrin receptor signaling pathway uc009tvi.1 uc009tvi.2 uc009tvi.3 uc009tvi.4 
ENSMUST00000052853.8 Ubl4b ENSMUST00000052853.8 ubiquitin-like 4B (from RefSeq NM_026261.2) ENSMUST00000052853.1 ENSMUST00000052853.2 ENSMUST00000052853.3 ENSMUST00000052853.4 ENSMUST00000052853.5 ENSMUST00000052853.6 ENSMUST00000052853.7 NM_026261 Q5RL34 Q9CQ84 UBL4B_MOUSE uc008qxe.1 uc008qxe.2 uc008qxe.3 Cytoplasm Expressed specifically in post-meiotic male germ cells of the testis. Abundantly expressed in stage 14-16 spermatids. May have arisen from retrotransposition of the X-linked Ubl4a gene during mammalian evolution. Sequence=AAH48443.1; Type=Frameshift; Evidence=; molecular_function cellular_component cytoplasm uc008qxe.1 uc008qxe.2 uc008qxe.3 
ENSMUST00000052865.16 Tmem123 ENSMUST00000052865.16 transmembrane protein 123, transcript variant 1 (from RefSeq NM_133739.2) ENSMUST00000052865.1 ENSMUST00000052865.10 ENSMUST00000052865.11 ENSMUST00000052865.12 ENSMUST00000052865.13 ENSMUST00000052865.14 ENSMUST00000052865.15 ENSMUST00000052865.2 ENSMUST00000052865.3 ENSMUST00000052865.4 ENSMUST00000052865.5 ENSMUST00000052865.6 ENSMUST00000052865.7 ENSMUST00000052865.8 ENSMUST00000052865.9 NM_133739 PORIM_MOUSE Q3T9F6 Q3TLL2 Q3U1R6 Q8CEX4 Q91Z22 uc009ocx.1 uc009ocx.2 uc009ocx.3 uc009ocx.4 uc009ocx.5 Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability. Membrane ; Single-pass type I membrane protein Belongs to the CD164 family. molecular_function external side of plasma membrane membrane integral component of membrane cytoplasmic vesicle oncosis uc009ocx.1 uc009ocx.2 uc009ocx.3 uc009ocx.4 uc009ocx.5 
ENSMUST00000052876.3 Eva1b ENSMUST00000052876.3 Membrane ; Single-pass membrane protein (from UniProt Q8K2Y3) AK077984 B1AW02 ENSMUST00000052876.1 ENSMUST00000052876.2 EVA1B_MOUSE Fam176b Q8K2Y3 uc008uso.1 uc008uso.2 uc008uso.3 Membrane ; Single-pass membrane protein Belongs to the EVA1 family. protein binding cellular_component membrane integral component of membrane uc008uso.1 uc008uso.2 uc008uso.3 
ENSMUST00000052885.14 Tmem259 ENSMUST00000052885.14 transmembrane protein 259, transcript variant 1 (from RefSeq NM_001359632.1) ENSMUST00000052885.1 ENSMUST00000052885.10 ENSMUST00000052885.11 ENSMUST00000052885.12 ENSMUST00000052885.13 ENSMUST00000052885.2 ENSMUST00000052885.3 ENSMUST00000052885.4 ENSMUST00000052885.5 ENSMUST00000052885.6 ENSMUST00000052885.7 ENSMUST00000052885.8 ENSMUST00000052885.9 MBRL_MOUSE NM_001359632 ORF61 Q68EE1 Q6KAN7 Q7TS84 Q8CIV1 Q8CIV2 Q99K29 uc007gax.1 uc007gax.2 uc007gax.3 May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress. Interacts with ERLIN2. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Membralin-1; IsoId=Q8CIV2-1; Sequence=Displayed; Name=2; Synonyms=Membralin-2; IsoId=Q8CIV2-2; Sequence=VSP_014379; Detected in brain, spinal cord, lung, liver and kidney. Lethality typically occurs several days after birth, associated with motor neuron deficiency and paresis. Belongs to the membralin family. Sequence=AAH52787.1; Type=Erroneous initiation; Evidence=; protein binding endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane response to endoplasmic reticulum stress negative regulation of neuron death positive regulation of ERAD pathway uc007gax.1 uc007gax.2 uc007gax.3 
ENSMUST00000052902.10 ENSMUSG00000121782 ENSMUST00000052902.10 ENSMUSG00000121782 (from geneSymbol) ENSMUST00000052902.1 ENSMUST00000052902.2 ENSMUST00000052902.3 ENSMUST00000052902.4 ENSMUST00000052902.5 ENSMUST00000052902.6 ENSMUST00000052902.7 ENSMUST00000052902.8 ENSMUST00000052902.9 LF197916 uc287pny.1 uc287pny.2 uc287pny.3 uc287pny.1 uc287pny.2 uc287pny.3 
ENSMUST00000052907.7 Adamts19 ENSMUST00000052907.7 ADAM metallopeptidase with thrombospondin type 1 motif 19 (from RefSeq NM_175506.4) ATS19_MOUSE ENSMUST00000052907.1 ENSMUST00000052907.2 ENSMUST00000052907.3 ENSMUST00000052907.4 ENSMUST00000052907.5 ENSMUST00000052907.6 NM_175506 P59509 uc008ezs.1 uc008ezs.2 uc008ezs.3 This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is predominantly expressed in the ovary with lower levels of expression observed in kidney, heart, skeletal muscle, lung and testis. The encoded preproprotein undergoes proteolytic processing to generate an active protease. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY135183.1, BC150736.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix Expressed predominantly in fetal ovary, low levels of expression is also detected in kidney, heart, skeletal muscle, lung and testis. Expression is strongest in anterior and ventral regions of the ovary at 12.5 and 13.5 dpc before becoming more uniform. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2- G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3- glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). Homozygous knockout mice are viable, fertile and born in Mendelian ratios. Echocardiographic analysis reveals progressive aortic valve disease, without dysfunction in any of other valves. Valve defects range from aortic regurgitation to severe aortic valve stenosis, or a combination of both. Dysfunctional aortic valves show thickening of the commissures with reduced opening of the valve, occasionally in a 'fish mouth' pattern with only 2 visible commissures, reminiscent of fused bicuspid aortic valves in humans. The extracellular matrix is disorganized throughout the aortic valve leaflets, with significant thickening at the hinge region of the leaflets and increased collagen deposition covering the raphe. There is no evidence of valve calcification. By homology with the human sequence, it is uncertain whether Met-1 or Met-5 is the initiator. metalloendopeptidase activity extracellular region proteolysis peptidase activity metallopeptidase activity hydrolase activity metal ion binding uc008ezs.1 uc008ezs.2 uc008ezs.3 
ENSMUST00000052910.6 Acot10 ENSMUST00000052910.6 acyl-CoA thioesterase 10 (from RefSeq NM_022816.2) A0FJF7 ACO10_MOUSE Acot10 ENSMUST00000052910.1 ENSMUST00000052910.2 ENSMUST00000052910.3 ENSMUST00000052910.4 ENSMUST00000052910.5 NM_022816 Q32MW2 Q32MW3 uc007vio.1 uc007vio.2 Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Active on long chain acyl-CoAs. Mitochondrion Belongs to the acyl coenzyme A hydrolase family. mitochondrion acyl-CoA metabolic process hydrolase activity acyl-CoA hydrolase activity carboxylic ester hydrolase activity uc007vio.1 uc007vio.2 
ENSMUST00000052915.14 Axin2 ENSMUST00000052915.14 axin 2, transcript variant 1 (from RefSeq NM_015732.4) AXIN2_MOUSE Axin2 ENSMUST00000052915.1 ENSMUST00000052915.10 ENSMUST00000052915.11 ENSMUST00000052915.12 ENSMUST00000052915.13 ENSMUST00000052915.2 ENSMUST00000052915.3 ENSMUST00000052915.4 ENSMUST00000052915.5 ENSMUST00000052915.6 ENSMUST00000052915.7 ENSMUST00000052915.8 ENSMUST00000052915.9 NM_015732 O88566 Q6PFZ9 Q9QXJ6 uc007mbu.1 uc007mbu.2 uc007mbu.3 uc007mbu.4 Inhibitor of the Wnt signaling pathway. Down-regulates beta- catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin. Interacts with SMAD7 and RNF111 (By similarity). Interacts with ANKRD6 (PubMed:12183362). Interacts with SIAH1 (By similarity). Interacts with SIAH2 (By similarity). O88566; Q8N944: AMER3; Xeno; NbExp=2; IntAct=EBI-7690990, EBI-8869590; O88566; Q12834: CDC20; Xeno; NbExp=2; IntAct=EBI-7690990, EBI-367462; O88566; Q9BV73: CEP250; Xeno; NbExp=3; IntAct=EBI-7690990, EBI-1053100; O88566; Q15583: TGIF1; Xeno; NbExp=3; IntAct=EBI-7690990, EBI-714215; Cytoplasm Expressed in Tcf7-positive innate-like T-cells (at protein level). Expressed in the distal tooth bud epithelium during the bud stage of mandibular molar tooth development. The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription. Probably phosphorylated by GSK3B and dephosphorylated by PP2A. somitogenesis positive regulation of protein phosphorylation intramembranous ossification secondary heart field specification chondrocyte differentiation involved in endochondral bone morphogenesis protein binding nucleus cytoplasm centrosome beta-catenin binding cell death cell proliferation negative regulation of cell proliferation positive regulation of epithelial to mesenchymal transition positive regulation of cell death Wnt signaling pathway enzyme binding protein kinase binding regulation of Wnt signaling pathway bone mineralization ubiquitin protein ligase binding regulation of mismatch repair macromolecular complex cellular protein localization odontogenesis maintenance of DNA repeat elements negative regulation of osteoblast differentiation positive regulation of protein kinase activity mRNA stabilization regulation of chondrocyte development I-SMAD binding regulation of centromeric sister chromatid cohesion negative regulation of canonical Wnt signaling pathway negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification uc007mbu.1 uc007mbu.2 uc007mbu.3 uc007mbu.4 
ENSMUST00000052919.8 Ormdl3 ENSMUST00000052919.8 ORM1-like 3 (S. cerevisiae) (from RefSeq NM_025661.4) A2A4X7 ENSMUST00000052919.1 ENSMUST00000052919.2 ENSMUST00000052919.3 ENSMUST00000052919.4 ENSMUST00000052919.5 ENSMUST00000052919.6 ENSMUST00000052919.7 NM_025661 ORML3_MOUSE Q8BN65 Q8R0U5 Q9CPZ6 uc007lgr.1 uc007lgr.2 uc007lgr.3 Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:31880535, PubMed:30700557). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity). Ceramide-sensitive subunit of the serine palmitoyltransferase (SPT) complex, which is also composed of SPTLC1, SPTLC2/3 and SPTSSA/B. Endoplasmic reticulum membrane ; Multi-pass membrane protein Ceramides bind to ORMDL3 N-terminus and stabilize it in a conformation that physically restricts the accessibility of the substrates to their binding sites in the serine palmitoyltransferase (SPT) complex, hence inhibiting SPT catalytic activity. In the absence of ceramides, the N-terminus is flexible and permits substrate binding, thus liberating SPT from inhibition. When hydroxylated at Pro-137, ubiquitinated via 'Lys-48'-linkage, leading to proteasomal degradation. In endothelial cells, ORMDL3 proteasomal degradation is controlled by the sphingosine 1-phosphate receptor signaling pathway. No overt phenotype, although knockout mice show elevated brain levels of sphingolipids, including dihydrosphingosine, dihydroceramide, ceramide and sphingosine, compared with wild-type animals (PubMed:31880535). Double knockdown of ORMDL1 and ORMDL3 show elevated brain levels of sphingolipids, compared with single knockout and wild-type animals (PubMed:31880535). At 8 weeks of age, both male and female ORMDL1/3 double knockout mice weigh significantly less than wild-type mice and exhibit impaired myelination and motor-function abnormalities (PubMed:31880535). The triple knockout ORMDL1, ORMDL2 and ORMDL3 is not viable (PubMed:31880535). Belongs to the ORM family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane ceramide metabolic process membrane integral component of membrane SPOTS complex cellular sphingolipid homeostasis negative regulation of ceramide biosynthetic process uc007lgr.1 uc007lgr.2 uc007lgr.3 
ENSMUST00000052927.11 Ppp1r16b ENSMUST00000052927.11 Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (PubMed:21907835). Involved in the regulation of the PI3K/AKT signaling pathway (By similarity). Involved in the regulation of angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (By similarity). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (By similarity). Involved in the dephosphorylation of EEF1A1 (By similarity). (from UniProt Q8VHQ3) AK042123 ENSMUST00000052927.1 ENSMUST00000052927.10 ENSMUST00000052927.2 ENSMUST00000052927.3 ENSMUST00000052927.4 ENSMUST00000052927.5 ENSMUST00000052927.6 ENSMUST00000052927.7 ENSMUST00000052927.8 ENSMUST00000052927.9 PP16B_MOUSE Q8VHQ3 uc012cil.1 uc012cil.2 uc012cil.3 Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (PubMed:21907835). Involved in the regulation of the PI3K/AKT signaling pathway (By similarity). Involved in the regulation of angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (By similarity). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (By similarity). Involved in the dephosphorylation of EEF1A1 (By similarity). Interacts with PPP1CA, PPP1CB and MSN. Interacts (via its fourth ankyrin repeat) with the mature dimeric form of RPSA/LAMR1 (By similarity). Interacts with EEF1A1 (By similarity). Interacts with PTEN (By similarity). Interacts with ECE1 (By similarity). Cell membrane Cell membrane ; Lipid-anchor Nucleus Cell projection Note=Colocalizes with RPSA/LAMR1 in the cell membrane (By similarity). Localizes to the perinuclear region (By similarity). Colocalizes with PTEN at the tip of EC projections (By similarity). Inhibited by TGF-beta1 (Probable). Down-regulated by LPS (PubMed:21907835). Phosphorylated by PKA and, after PKA priming, by GSK3B. Phosphorylation by GSK3B reduces its association with PP1C and enhances PP1C activity. Dephosphorylation by its associated PP1C results in enhanced association with PP1C, but reduced PP1C activity (By similarity). positive regulation of endothelial cell proliferation nucleus plasma membrane regulation of phosphatidylinositol 3-kinase signaling membrane nuclear speck protein phosphatase regulator activity regulation of protein dephosphorylation positive regulation of protein dephosphorylation negative regulation of protein dephosphorylation cell projection regulation of phosphoprotein phosphatase activity perinuclear region of cytoplasm regulation of filopodium assembly establishment of endothelial barrier negative regulation of peptidyl-serine dephosphorylation positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis uc012cil.1 uc012cil.2 uc012cil.3 
ENSMUST00000052932.10 Pde12 ENSMUST00000052932.10 phosphodiesterase 12 (from RefSeq NM_178668.4) ENSMUST00000052932.1 ENSMUST00000052932.2 ENSMUST00000052932.3 ENSMUST00000052932.4 ENSMUST00000052932.5 ENSMUST00000052932.6 ENSMUST00000052932.7 ENSMUST00000052932.8 ENSMUST00000052932.9 NM_178668 PDE12_MOUSE Q3TIU4 Q3TTY4 Q6P2L5 Q8BKH8 Q8BTS8 Q8BUQ5 uc056yvx.1 uc056yvx.2 uc056yvx.3 Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells. Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Mitochondrion matrix Belongs to the CCR4/nocturin family. Sequence=BAC34827.1; Type=Erroneous initiation; Evidence=; 3'-5'-exoribonuclease activity nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay mitochondrial mRNA catabolic process nuclease activity exonuclease activity poly(A)-specific ribonuclease activity mitochondrion mitochondrial matrix mRNA processing hydrolase activity cellular response to interferon-alpha regulation of mitochondrial mRNA stability positive regulation of viral genome replication metal ion binding negative regulation of cell death cellular response to interferon-gamma cellular response to dsRNA nucleic acid phosphodiester bond hydrolysis negative regulation of oxidative phosphorylation RNA phosphodiester bond hydrolysis, exonucleolytic uc056yvx.1 uc056yvx.2 uc056yvx.3 
ENSMUST00000052939.4 Camk2n2 ENSMUST00000052939.4 calcium/calmodulin-dependent protein kinase II inhibitor 2 (from RefSeq NM_028420.2) CK2N2_MOUSE ENSMUST00000052939.1 ENSMUST00000052939.2 ENSMUST00000052939.3 NM_028420 Q78WH7 uc007yqk.1 uc007yqk.2 uc007yqk.3 uc007yqk.4 Potent and specific cellular inhibitor of CaM-kinase II (CAMK2) (By similarity). Traps Ca(2+)/calmodulin on CAMK2 (By similarity). Interacts with CAMK2A and CAMK2B in the presence of Ca(2+)/calmodulin or after autophosphorylation. Nucleus Cytoplasm, cytosol Synapse Note=Excluded from nucleus when coexpressed with activated CAMK2. Belongs to the CAMK2N family. protein kinase inhibitor activity nucleus cytoplasm centrosome cytosol negative regulation of protein kinase activity calcium-dependent protein kinase inhibitor activity protein kinase binding uc007yqk.1 uc007yqk.2 uc007yqk.3 uc007yqk.4 
ENSMUST00000052946.12 Tbx20 ENSMUST00000052946.12 T-box 20, transcript variant 1 (from RefSeq NM_194263.3) ENSMUST00000052946.1 ENSMUST00000052946.10 ENSMUST00000052946.11 ENSMUST00000052946.2 ENSMUST00000052946.3 ENSMUST00000052946.4 ENSMUST00000052946.5 ENSMUST00000052946.6 ENSMUST00000052946.7 ENSMUST00000052946.8 ENSMUST00000052946.9 NM_194263 Q9EPZ5 Q9ES03 Q9ESX1 TBX20_MOUSE Tbx12 uc009ope.1 uc009ope.2 uc009ope.3 uc009ope.4 Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ES03-1; Sequence=Displayed; Name=2; IsoId=Q9ES03-2; Sequence=VSP_021730; Prominently expressed in the extraembryonic mesoderm, developing heart, eye analage and motor neurons of hindbrain and spinal cord. Expressed in extraembryonic tissues such as the amnion and allantois. Between 7.25 dpc and 8 dpc, expression detected in the extraembryonic mesoderm and contributes to amnion and chorion. Allantois expression persists until 10.5 dpc and continues into the umbilical cord. Expression is found throughout heart development. At 7.5 dpc, detected in the cardiogenic mesoderm, at 8.0 dpc-8.5, found in the cardiac crescent and looping heart tube and from 9.5 dpc, found in the forming four-chambered heart. At all stages, expression is much stronger in the myocardium than in the endocardium and expression extends from the cardiogenic into the lateral plate mesoderm. From 10.5 dpc on, weakly expressed in the periphery of the liver lobes, and in cells surrounding the aorta in the urogenital system. At 9.0 dpc, weakly expressed in the dorsal half of the optic vesicle. Later, expression spreads ventrally to enclose the entire neural retina at 11.5 dpc. At 9.0 dpc, expression is initiated in the hindbrain: first in the ventral region of rhombomere (r) 2 and 4, then in r7, r8 and in the cervical spinal cord. By 10.5 dpc, two ventral stripes of Tbx20 containing cells are continuous from r2 into the cervical spinal cord and expression is seen in two symmetrical patches of cell bodies in the mantle region of the ventral neural tube. At 11.5 dpc, expression follows the migration of motor neurons. Embryos die at mid-gestation. The heart tube of deficient mice does not elongate, but anterior and secondary heart field markers are not affected. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding branching involved in blood vessel morphogenesis vasculogenesis cell fate specification neuron migration heart looping embryonic heart tube morphogenesis outflow tract septum morphogenesis outflow tract morphogenesis tricuspid valve development aortic valve development aortic valve morphogenesis pulmonary valve formation endocardial cushion morphogenesis cardiac chamber formation cardiac right ventricle morphogenesis endocardial cushion formation cardiac septum development pericardium morphogenesis DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated muscle contraction multicellular organism development blood circulation cell proliferation dorsal/ventral pattern formation regulation of epithelial to mesenchymal transition negative regulation of SMAD protein complex assembly visceral motor neuron differentiation embryonic heart tube development foramen ovale closure embryonic heart tube elongation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cardiac muscle tissue morphogenesis positive regulation of cardiac muscle cell proliferation atrial septum morphogenesis pulmonary vein morphogenesis uc009ope.1 uc009ope.2 uc009ope.3 uc009ope.4 
ENSMUST00000052949.13 Hk3 ENSMUST00000052949.13 hexokinase 3, transcript variant 1 (from RefSeq NM_001033245.4) ENSMUST00000052949.1 ENSMUST00000052949.10 ENSMUST00000052949.11 ENSMUST00000052949.12 ENSMUST00000052949.2 ENSMUST00000052949.3 ENSMUST00000052949.4 ENSMUST00000052949.5 ENSMUST00000052949.6 ENSMUST00000052949.7 ENSMUST00000052949.8 ENSMUST00000052949.9 HXK3_MOUSE Hk3 NM_001033245 Q3TAX6 Q3TRM8 Q3UDP1 Q3UEA4 uc007qpt.1 uc007qpt.2 uc007qpt.3 Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+); Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741; Evidence=; Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+); Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126; Evidence=; Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+); Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826; Evidence=; Hexokinase is an allosteric enzyme inhibited by its product D-glucose 6-phosphate. Carbohydrate metabolism; hexose metabolism. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 1/4. The N- and C-terminal halves of this hexokinase contain a hexokinase domain. The catalytic activity is associated with the C- terminus while regulatory function is associated with the N-terminus. Belongs to the hexokinase family. nucleotide binding cellular glucose homeostasis catalytic activity glucokinase activity hexokinase activity ATP binding glucose binding mitochondrion cytosol carbohydrate metabolic process fructose 6-phosphate metabolic process glycolytic process metabolic process fructokinase activity kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor mannokinase activity hexose metabolic process enzyme binding macromolecular complex hormone binding carbohydrate phosphorylation glucose 6-phosphate metabolic process negative regulation of hydrogen peroxide-mediated programmed cell death uc007qpt.1 uc007qpt.2 uc007qpt.3 
ENSMUST00000052965.8 Nipbl ENSMUST00000052965.8 NIPBL cohesin loading factor, transcript variant b (from RefSeq NM_201232.2) ENSMUST00000052965.1 ENSMUST00000052965.2 ENSMUST00000052965.3 ENSMUST00000052965.4 ENSMUST00000052965.5 ENSMUST00000052965.6 ENSMUST00000052965.7 NIPBL_MOUSE NM_201232 Q6KC78 Q6KCD5 Q7TNS4 Q8BKV4 Q8CES9 Q9CUC6 Scc2 uc007veq.1 uc007veq.2 uc007veq.3 uc007veq.4 Plays an important role in the loading of the cohesin complex on to DNA (PubMed:29094699). Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (By similarity). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (PubMed:28041881). Heterodimerizes with MAU2/SCC4 to form the cohesin loading complex (By similarity). The NIPBL-MAU2 heterodimer interacts with the cohesin complex composed of SMC1A/B and SMC3 heterodimer, RAD21 and STAG1/SA1. NIPBL directly contacts all members of the complex, RAD21, SMC1A/B, SMC3 and STAG1 (By similarity). Interacts directly (via PxVxL motif) with CBX3 and CBX5 (By similarity). Interacts with ZNF609 (via N-terminus) (PubMed:28041881). Interacts with the multiprotein complex Integrator (PubMed:28041881). Nucleus romosome Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6KCD5-1; Sequence=Displayed; Name=2; IsoId=Q6KCD5-2; Sequence=VSP_011098, VSP_011099; Name=3; IsoId=Q6KCD5-3; Sequence=VSP_011094; Name=4; IsoId=Q6KCD5-4; Sequence=VSP_011095, VSP_011096, VSP_011097; Spermatocytes and oocytes (at protein level). Widely expressed at 9.5 and 10.5 dpc, with notable accumulations in limb bud, branchial arch and craniofacial mesenchyme. These regions are involved in patterning of the skeleton and soft tissues of the limbs, jaw and face. Expressed in the developing brain, with enrichment in the ventricular zone at 14.5 dpc (PubMed:28041881). Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain. The C-terminal region containing HEAT repeats and Pro-Xaa-Val- Xaa-Leu (PxVxL) motif are involved in the recruitment of NIPBL to sites of DNA damage. Deletion of NIPBL in mouse liver leads to strong depletion of chromatin-bound cohesin and marked reorganization of chromosomal folding. Cells retain transcriptionally active (type A) and transcriptionally inactive (type B) compartments, but lose topologically associating domains (TADs) patterns and TAD-associated peaks of contact enrichment across the whole genome. The compartmentalization of chromatin in cells lacking NIPBL is enhanced around 1.8-fold compared with controls. Belongs to the SCC2/Nipped-B family. negative regulation of transcription from RNA polymerase II promoter nuclear chromosome chromatin nuclear chromatin heart morphogenesis outflow tract morphogenesis chromatin binding protein binding nucleus chromosome double-strand break repair regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus cell cycle mitotic sister chromatid cohesion mitotic chromosome condensation multicellular organism development brain development heart development sensory perception of sound protein C-terminus binding regulation of gene expression stem cell population maintenance positive regulation of histone deacetylation integrator complex SMC loading complex establishment of mitotic sister chromatid cohesion maintenance of mitotic sister chromatid cohesion cellular protein localization embryonic forelimb morphogenesis forelimb morphogenesis external genitalia morphogenesis mediator complex binding positive regulation of multicellular organism growth ear morphogenesis regulation of hair cycle histone deacetylase binding fat cell differentiation positive regulation of ossification negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development protein N-terminus binding embryonic digestive tract morphogenesis developmental growth eye morphogenesis regulation of developmental growth embryonic cranial skeleton morphogenesis embryonic viscerocranium morphogenesis cognition face morphogenesis gall bladder development uterus morphogenesis chromo shadow domain binding rDNA condensation establishment of protein localization to chromatin cellular response to X-ray transcriptional activation by promoter-enhancer looping cohesin loading Scc2-Scc4 cohesin loading complex positive regulation of mitotic cohesin loading replication-born double-strand break repair via sister chromatid exchange positive regulation of neuron migration uc007veq.1 uc007veq.2 uc007veq.3 uc007veq.4 
ENSMUST00000052969.15 Ston2 ENSMUST00000052969.15 stonin 2, transcript variant 1 (from RefSeq NM_175367.7) A2RTJ7 ENSMUST00000052969.1 ENSMUST00000052969.10 ENSMUST00000052969.11 ENSMUST00000052969.12 ENSMUST00000052969.13 ENSMUST00000052969.14 ENSMUST00000052969.2 ENSMUST00000052969.3 ENSMUST00000052969.4 ENSMUST00000052969.5 ENSMUST00000052969.6 ENSMUST00000052969.7 ENSMUST00000052969.8 ENSMUST00000052969.9 NM_175367 Q8BZ60 STON2_MOUSE Stn2 Stnb uc007okt.1 uc007okt.2 uc007okt.3 Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating (By similarity). Interacts with the second C2 domain of synaptotagmins SYT1 and SYT2. Interacts with EPS15, EPS15R and ITSN1. Interacts indirectly with the AP-2 adapter complex. Interacts with TOR1A and COPS4; the interaction controls STON2 protein stability (By similarity). Cytoplasm Membrane Synapse, synaptosome Note=Some fraction is membrane- associated. The Asn-Pro-Phe (NPF) motifs, which are found in proteins involved in the endocytic pathway, mediate the interaction with the EH domain of SYT1, SYT2, EPS15, EPS15R and ITSN1. Phosphorylated in vitro by PKD. Neddylated; deneddylated via its interaction with the COP9 signalosome (CSN) complex through TOR1A and COPS4. Ubiquitinated; leading to its degradation. Belongs to the Stoned B family. hematopoietic progenitor cell differentiation protein binding nucleolus cytoplasm cytosol endocytosis chemical synaptic transmission synaptic vesicle membrane cell junction regulation of endocytosis clathrin-coated vesicle synaptic vesicle recycling neuron projection synapse synaptic vesicle endocytosis presynapse uc007okt.1 uc007okt.2 uc007okt.3 
ENSMUST00000052978.6 Spata31d1d ENSMUST00000052978.6 spermatogenesis associated 31 subfamily D, member 1D (from RefSeq NM_177711.3) E9Q5W2 E9Q5W2_MOUSE ENSMUST00000052978.1 ENSMUST00000052978.2 ENSMUST00000052978.3 ENSMUST00000052978.4 ENSMUST00000052978.5 NM_177711 Spata31d1d uc007qvb.1 uc007qvb.2 Membrane ; Single- pass membrane protein Belongs to the SPATA31 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007qvb.1 uc007qvb.2 
ENSMUST00000052999.13 Echdc2 ENSMUST00000052999.13 enoyl Coenzyme A hydratase domain containing 2, transcript variant 1 (from RefSeq NM_026728.4) A2APS6 D4Ertd765e ECHD2_MOUSE ENSMUST00000052999.1 ENSMUST00000052999.10 ENSMUST00000052999.11 ENSMUST00000052999.12 ENSMUST00000052999.2 ENSMUST00000052999.3 ENSMUST00000052999.4 ENSMUST00000052999.5 ENSMUST00000052999.6 ENSMUST00000052999.7 ENSMUST00000052999.8 ENSMUST00000052999.9 NM_026728 Q3TKJ7 Q3TLP5 Q3TV08 Q3U553 Q8R3K4 Q9DBD3 uc008uat.1 uc008uat.2 uc008uat.3 uc008uat.4 Mitochondrion Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TLP5-1; Sequence=Displayed; Name=2; IsoId=Q3TLP5-2; Sequence=VSP_029179; Name=3; IsoId=Q3TLP5-3; Sequence=VSP_029178; Belongs to the enoyl-CoA hydratase/isomerase family. Sequence=AAH25104.1; Type=Erroneous initiation; Evidence=; Sequence=BAB23757.1; Type=Frameshift; Evidence=; Sequence=BAE32227.1; Type=Frameshift; Evidence=; catalytic activity enoyl-CoA hydratase activity mitochondrion lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation lyase activity uc008uat.1 uc008uat.2 uc008uat.3 uc008uat.4 
ENSMUST00000053013.6 Otol1 ENSMUST00000053013.6 otolin 1 (from RefSeq NM_001018031.2) B9EKG7 ENSMUST00000053013.1 ENSMUST00000053013.2 ENSMUST00000053013.3 ENSMUST00000053013.4 ENSMUST00000053013.5 Gm414 NM_001018031 OTOL1_MOUSE Otol1 Q3TYP6 Q4ZJM7 uc008pmo.1 uc008pmo.2 uc008pmo.3 Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear (PubMed:21655225, PubMed:24748133, PubMed:29076638). Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure (PubMed:21655225, PubMed:24748133, PubMed:29076638). Together with OC90, modulates calcite crystal morphology and growth kinetics (PubMed:24748133). Homooligomer; disulfide-linked; probably forms homotrimers (PubMed:20856818, PubMed:24748133, PubMed:29076638). Interacts with OC90 (PubMed:17300776, PubMed:20856818, PubMed:21655225). Interacts with CBLN1 (PubMed:20856818). Secreted, extracellular space, extracellular matrix Note=Localized in both the surrounding otoconial matrix and otoconia. Expressed in the organic matrix of otoconia (at protein level) (PubMed:17300776, PubMed:22841569). Expressed in neonatal sensory epithelium of vestibular utricle and saccule and also in otoconia (PubMed:21655225). The C1q domain mediates calcium-binding. Not N-glycosylated. Belongs to the OTOL1 family. extracellular matrix structural constituent calcium ion binding protein binding extracellular region collagen trimer extracellular space extracellular matrix organization extracellular matrix otolith mineralization metal ion binding protein homooligomerization uc008pmo.1 uc008pmo.2 uc008pmo.3 
ENSMUST00000053015.7 Pcbp1 ENSMUST00000053015.7 poly(rC) binding protein 1 (from RefSeq NM_011865.4) ENSMUST00000053015.1 ENSMUST00000053015.2 ENSMUST00000053015.3 ENSMUST00000053015.4 ENSMUST00000053015.5 ENSMUST00000053015.6 NM_011865 P60335 PCBP1_MOUSE uc009csc.1 uc009csc.2 uc009csc.3 uc009csc.4 Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (PubMed:34180713). P60335; Q99N13: Hdac9; NbExp=6; IntAct=EBI-309059, EBI-645361; Nucleus Cytoplasm Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm. Phosphorylated; lowers poly(rC)-binding activity. Embryonic lethality in the peri-implantation stage (between dpc 4.5 and dpc 8.5) (PubMed:26527618). Conditional deletion in the erythroid lineage is not lethal and does not lead to defects in the hematopoietic pathway (PubMed:34180713). Mice lacking Pcbp1 and Pcbp2 in the erythroid lineage die at midgestation; lethality is caused by impaired erythroid development and loss of blood formation (PubMed:34180713). RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleic acid binding DNA binding single-stranded DNA binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding nucleus nucleoplasm cytoplasm cytosol mRNA processing translation activator activity nuclear speck cytoplasmic ribonucleoprotein granule viral RNA genome replication positive regulation of translation positive regulation of transcription from RNA polymerase II promoter sequence-specific single stranded DNA binding uc009csc.1 uc009csc.2 uc009csc.3 uc009csc.4 
ENSMUST00000053016.10 Pou4f1 ENSMUST00000053016.10 POU domain, class 4, transcription factor 1 (from RefSeq NM_011143.4) Brn-3 Brn3 Brn3a E9QPT6 ENSMUST00000053016.1 ENSMUST00000053016.2 ENSMUST00000053016.3 ENSMUST00000053016.4 ENSMUST00000053016.5 ENSMUST00000053016.6 ENSMUST00000053016.7 ENSMUST00000053016.8 ENSMUST00000053016.9 NM_011143 P17208 PO4F1_MOUSE uc007uxb.1 uc007uxb.2 uc007uxb.3 uc007uxb.4 uc007uxb.5 Multifunctional transcription factor with different regions mediating its different effects (PubMed:10640682, PubMed:8621561, PubMed:9694219, PubMed:9722627). Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:8621561, PubMed:17668438). Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor (PubMed:12934100). Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain) (PubMed:9722627). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins (PubMed:8972215). Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity (PubMed:9448000). May positively regulate POU4F2 and POU4F3 (PubMed:8876243). Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord (PubMed:22326227). Plays a role in TNFSF11-mediated terminal osteoclast differentiation (PubMed:17668438). Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site (PubMed:12441296). [Isoform 2]: Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1 (PubMed:12934100). Does not have antiapoptotic effect on neuronal cells (PubMed:9722627). Interacts (via N-terminus) with RIT2; the interaction controls POU4F1 transactivation activity on some neuronal target genes (PubMed:12934100). Isoform 1 interacts with POU4F2 isoform 2; this interaction inhibits both POU4F1 DNA-binding and transcriptional activities (PubMed:8537352). Isoform 1 interacts (C-terminus) with ESR1 (via DNA-binding domain); this interaction decreases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta- estradiol-independent manner (PubMed:9448000). Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Brn-3A-Long ; IsoId=P17208-1; Sequence=Displayed; Name=2 ; Synonyms=Brn-3A-Short ; IsoId=P17208-2; Sequence=VSP_058637; Expressed in mature osteoclasts (at protein level) (PubMed:17668438). Brain, peripheral sensory nervous system and retina (PubMed:8162704). In the adult nervous system, predominates in the medial habenula, superficial gray of the superior colliculus, red nucleus, mesencephalic nucleus of the trigeminal ganglion, nucleus ambiguus, inferior olivary nucleus, and peripheral sensory ganglia (PubMed:8290353). Expressed in the spinal cord from 11 dpc to the adult stage (PubMed:8290353). As early as 10.5 dpc to 15.5 dpc, strongly expressed in all dorsal root ganglion neurons (PubMed:22326227). In retinal ganglion cells, expression starts at 15.5 dpc and exhibits a slow decrease with moderate levels detectable at P8 (PubMed:8637595). Up-regulated by the osteoclast differentiation factor TNFSF11 (PubMed:17668438). The C-terminal domain is able to act as both DNA-binding domain and a transcriptional activator. The N-terminal domain is also required for transactivation activity on some target genes acting as a discrete activation domain (PubMed:8621561, PubMed:9722627). Neurite outgrowth and expression of genes required for synapse formation are primarily dependent on the C-terminal domain, however the N-terminal domain is required for maximal induction (PubMed:8972215). Mutants have defective suckling and uncoordinated limb and trunk movements, leading to early postnatal death. They show a loss of neurons in the trigerminal ganglia, the medial habenula, the red nucleus and the caudal region of the inferior olivary nucleus (PubMed:8876243). Mutant dorsal root ganglions are defective in sensory neuron specification, and sensory afferent axons fail to form normal trajectories in the spinal cord (PubMed:22326227). Belongs to the POU transcription factor family. Class-4 subfamily. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding suckling behavior ventricular compact myocardium morphogenesis DNA binding chromatin binding single-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity transcription corepressor activity protein binding nucleus cytoplasm regulation of transcription, DNA-templated multicellular organism development nervous system development mesoderm development heart development positive regulation of gene expression negative regulation of gene expression cell migration in hindbrain trigeminal nerve development central nervous system neuron differentiation habenula development neuron differentiation neuron projection development neuron projection positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of programmed cell death negative regulation of neuron apoptotic process sequence-specific DNA binding positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter neuron fate specification sensory system development peripheral nervous system neuron differentiation peripheral nervous system neuron development regulation of neurogenesis GTPase binding regulation of sequence-specific DNA binding transcription factor activity proprioception involved in equilibrioception innervation positive regulation of cell cycle arrest cellular response to cytokine stimulus cellular response to estradiol stimulus intrinsic apoptotic signaling pathway by p53 class mediator RNA polymerase II transcription factor complex positive regulation of transcription regulatory region DNA binding negative regulation of transcription elongation from RNA polymerase I promoter uc007uxb.1 uc007uxb.2 uc007uxb.3 uc007uxb.4 uc007uxb.5 
ENSMUST00000053017.13 Chst9 ENSMUST00000053017.13 carbohydrate sulfotransferase 9, transcript variant 1 (from RefSeq NM_199055.3) CHST9_MOUSE ENSMUST00000053017.1 ENSMUST00000053017.10 ENSMUST00000053017.11 ENSMUST00000053017.12 ENSMUST00000053017.2 ENSMUST00000053017.3 ENSMUST00000053017.4 ENSMUST00000053017.5 ENSMUST00000053017.6 ENSMUST00000053017.7 ENSMUST00000053017.8 ENSMUST00000053017.9 NM_199055 Q76EC5 uc008edv.1 uc008edv.2 uc008edv.3 Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Golgi apparatus membrane ; Single- pass type II membrane protein Highly expressed in kidney and pituitary gland. Belongs to the sulfotransferase 2 family. Golgi membrane N-acetylgalactosamine 4-O-sulfotransferase activity Golgi apparatus carbohydrate metabolic process sulfur compound metabolic process sulfotransferase activity membrane integral component of membrane carbohydrate biosynthetic process transferase activity proteoglycan biosynthetic process uc008edv.1 uc008edv.2 uc008edv.3 
ENSMUST00000053020.8 Neurl1b ENSMUST00000053020.8 neuralized E3 ubiquitin protein ligase 1B (from RefSeq NM_001081656.3) C9DQJ8 ENSMUST00000053020.1 ENSMUST00000053020.2 ENSMUST00000053020.3 ENSMUST00000053020.4 ENSMUST00000053020.5 ENSMUST00000053020.6 ENSMUST00000053020.7 NEU1B_MOUSE NM_001081656 Neurl2 Neurl3 Q0MW30 uc008bed.1 uc008bed.2 uc008bed.3 uc008bed.4 E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with DLL1 and DLL4. Cytoplasm Expressed in the limb buds and dorsal root ganglia. Expressed in brain and kidney and at low levels in the heart. protein binding cytoplasm early endosome Notch signaling pathway protein ubiquitination transferase activity metal ion binding ubiquitin protein ligase activity ubiquitin-dependent endocytosis uc008bed.1 uc008bed.2 uc008bed.3 uc008bed.4 
ENSMUST00000053024.8 Pgp ENSMUST00000053024.8 phosphoglycolate phosphatase (from RefSeq NM_025954.4) ENSMUST00000053024.1 ENSMUST00000053024.2 ENSMUST00000053024.3 ENSMUST00000053024.4 ENSMUST00000053024.5 ENSMUST00000053024.6 ENSMUST00000053024.7 NM_025954 PGP_MOUSE Pgp Q8CHP8 uc008awe.1 uc008awe.2 uc008awe.3 uc008awe.4 Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism (PubMed:26755581). Was also shown to have a 2- phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581, PubMed:24338473). In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (PubMed:24338473). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Reaction=H2O + sn-glycerol 1-phosphate = glycerol + phosphate; Xref=Rhea:RHEA:46084, ChEBI:CHEBI:15377, ChEBI:CHEBI:17754, ChEBI:CHEBI:43474, ChEBI:CHEBI:57685; EC=3.1.3.21; Evidence=; Reaction=H2O + sn-glycerol 3-phosphate = glycerol + phosphate; Xref=Rhea:RHEA:66372, ChEBI:CHEBI:15377, ChEBI:CHEBI:17754, ChEBI:CHEBI:43474, ChEBI:CHEBI:57597; EC=3.1.3.21; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Inhibited by orthovanadate, beryllium trifluoride, Ca(2+) and EDTA. Kinetic parameters: KM=0.42 mM for ADP ; KM=1.23 mM for ATP ; KM=1.48 mM for GDP ; KM=1.47 mM for GTP ; KM=1.29 mM for glycerol-3-phosphate ; Vmax=100 nmol/min/mg enzyme with glycerol-3-phosphate as substrate ; Note=kcat is 0.1 sec(-1) with glycerol-3-phosphate. ; Homodimer. Ubiquitously expressed with higher expression in testis, heart, skeletal muscle and islet tissue (at protein level). Up-regulated in white adipose tissue and down-regulated in brown adipose tissue upon fasting. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. glycerol-1-phosphatase activity magnesium ion binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytoplasm carbohydrate metabolic process glycerol biosynthetic process glycerophospholipid metabolic process phosphoglycolate phosphatase activity dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation glycerol-3-phosphatase activity negative regulation of gluconeogenesis metal ion binding nucleotide phosphatase activity, acting on free nucleotides uc008awe.1 uc008awe.2 uc008awe.3 uc008awe.4 
ENSMUST00000053033.14 Macir ENSMUST00000053033.14 macrophage immunometabolism regulator, transcript variant 1 (from RefSeq NM_133825.3) D1Ertd622e ENSMUST00000053033.1 ENSMUST00000053033.10 ENSMUST00000053033.11 ENSMUST00000053033.12 ENSMUST00000053033.13 ENSMUST00000053033.2 ENSMUST00000053033.3 ENSMUST00000053033.4 ENSMUST00000053033.5 ENSMUST00000053033.6 ENSMUST00000053033.7 ENSMUST00000053033.8 ENSMUST00000053033.9 MACIR MACIR_MOUSE NM_133825 Q3UXG2 Q8VEB3 uc007cfh.1 uc007cfh.2 uc007cfh.3 uc007cfh.4 Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages. The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis. May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B. May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells. Interacts with UNC119 and UNC119B; interaction preferentially takes place when UNC119 and UNC119B are unliganded with myristoylated proteins. Cytoplasm Cell projection, cilium Note=Localizes to the transition zone and proximal cilium in addition to being found throughout the cytoplasm. Highly expressed in photoreceptors. Belongs to the UNC119-binding protein family. molecular_function cytoplasm cilium negative regulation of fibroblast migration protein transport cell projection organization ciliary transition zone cell projection cilium assembly negative regulation of cytokine production involved in inflammatory response uc007cfh.1 uc007cfh.2 uc007cfh.3 uc007cfh.4 
ENSMUST00000053035.7 Lrrc8e ENSMUST00000053035.7 leucine rich repeat containing 8 family, member E (from RefSeq NM_028175.2) E9QNV5 ENSMUST00000053035.1 ENSMUST00000053035.2 ENSMUST00000053035.3 ENSMUST00000053035.4 ENSMUST00000053035.5 ENSMUST00000053035.6 LRC8E_MOUSE Lrrc8e NM_028175 Q66JT1 uc009kth.1 uc009kth.2 uc009kth.3 Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (By similarity). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:32277911). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (By similarity). Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324, ChEBI:CHEBI:16382; Evidence=; Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328, ChEBI:CHEBI:507393; Evidence=; Reaction=2',3'-cGAMP(out) = 2',3'-cGAMP(in); Xref=Rhea:RHEA:66320, ChEBI:CHEBI:143093; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66321; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:66322; Evidence=; Heterohexamer. Oligomerizes with other LRRC8 proteins (LRRC8A, LRRC8C, LRRC8D and/or LRRC8B) to form a heterohexamer. Detected in a channel complex that contains LRRC8A, LRRC8C and LRRC8E. In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist. Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane Lysosome membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=In the absence of LRRC8A, resides primarily in the endoplasmic reticulum. Requires LRRC8A for localization at the cell membrane or lysosome membrane. The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins. No visible phenotype in normal conditions (PubMed:32277911). Impaired response to herpes simplex virus 1 (HSV-1) infection, caused by decreased ability to transport 2'-3'-cGAMP (PubMed:32277911). Belongs to the LRRC8 family. volume-sensitive anion channel activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane ion transport inorganic anion transport aspartate transport membrane integral component of membrane ion channel complex cellular response to osmotic stress anion transmembrane transport uc009kth.1 uc009kth.2 uc009kth.3 
ENSMUST00000053037.5 Pcdhb7 ENSMUST00000053037.5 protocadherin beta 7 (from RefSeq NM_053132.3) ENSMUST00000053037.1 ENSMUST00000053037.2 ENSMUST00000053037.3 ENSMUST00000053037.4 NM_053132 Pcdhb7 Q8CDY9 Q8CDY9_MOUSE uc008eps.1 uc008eps.2 uc008eps.3 calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eps.1 uc008eps.2 uc008eps.3 
ENSMUST00000053042.6 Zbtb8b ENSMUST00000053042.6 zinc finger and BTB domain containing 8b (from RefSeq NM_153541.4) A0A0R4J0Q8 A0A0R4J0Q8_MOUSE ENSMUST00000053042.1 ENSMUST00000053042.2 ENSMUST00000053042.3 ENSMUST00000053042.4 ENSMUST00000053042.5 NM_153541 Zbtb8b uc008uwy.1 uc008uwy.2 nucleic acid binding uc008uwy.1 uc008uwy.2 
ENSMUST00000053063.7 Hexim1 ENSMUST00000053063.7 hexamethylene bis-acetamide inducible 1 (from RefSeq NM_138753.2) Clp1 ENSMUST00000053063.1 ENSMUST00000053063.2 ENSMUST00000053063.3 ENSMUST00000053063.4 ENSMUST00000053063.5 ENSMUST00000053063.6 HEXI1_MOUSE NM_138753 Q8R409 uc007lto.1 uc007lto.2 uc007lto.3 uc007lto.4 Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa- B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Homooligomer and heterooligomer with HEXIM2; probably dimeric. Core component of the 7SK RNP complex, at least composed of 7SK RNA, LARP7, MEPCE, HEXIM1 (or HEXIM2) and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1). Interacts with the N-CoR complex through NCOR1. Interacts with ESR1 and NR3C1. May interact with NF-kappa-B through RELA. Interacts with CCNT2; mediates formation of a tripartite complex with KPNA2. Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 non-coding RNA. Q8R409; Q6PDM2: Srsf1; NbExp=4; IntAct=EBI-6261031, EBI-2550360; Q8R409; Q62093: Srsf2; NbExp=4; IntAct=EBI-6261031, EBI-2550402; Nucleus Cytoplasm Note=Binds alpha-importin and is mostly nuclear. Widely expressed with higher expression in heart, skeletal muscle and brain (at protein level). Up-regulated by HMBA (hexamethylene bisacetamide). The coiled-coil domain mediates oligomerization. Belongs to the HEXIM family. negative regulation of transcription from RNA polymerase II promoter activation of innate immune response immune system process cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding nucleus nucleoplasm cytoplasm heart development snRNA binding innate immune response negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated 7SK snRNA binding positive regulation of signal transduction by p53 class mediator uc007lto.1 uc007lto.2 uc007lto.3 uc007lto.4 
ENSMUST00000053068.7 Dmrt2 ENSMUST00000053068.7 doublesex and mab-3 related transcription factor 2 (from RefSeq NM_145831.3) DMRT2_MOUSE Dmrt2 ENSMUST00000053068.1 ENSMUST00000053068.2 ENSMUST00000053068.3 ENSMUST00000053068.4 ENSMUST00000053068.5 ENSMUST00000053068.6 NM_145831 Q3USI4 Q3USI7 Q8BG36 Q8K185 Q9JJU0 Q9JJU3 Q9WVM0 uc008hbm.1 uc008hbm.2 uc008hbm.3 uc008hbm.4 Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome. Is not required for sex determination and/or differentiation in embryonic development. Also not involved in symmetric somite formation and hence does not regulate the laterality pathway that controls left-right asymmetric organ positioning. Homodimer. Nucleus Expressed in testis. Expressed in presomitic mesoderm and developing somites at 8.5 dpc, accumulating in the epaxial domain at 9.5 dpc in the immature caudal somites. At 10.5 dpc expressed in the dermomyotome of somites. By 11.5 dpc, only detectable in caudal somites. In mature somites, expression is confined to the dermomyotome of the somite where Pax3 is also expressed and in the epaxial domain of the most immature caudal somites. At this stage, the most mature anterior somites are beginning to lose the expression at the epaxial and hypaxial extremities of the dermomyotome. At 14.5 dpc expressed in testis, heart and brain. Expression is also detected in proximal forelimb buds and branchial arches of the developing embryo. Transcriptionally up-regulated by PAX3 within the dermomyotome. Mice heterozygous for Dmrt2 mutation exhibit no visible phenotype. Homozygotes are perinatally lethal due to signs of respiratory distress. They have rib, sternal, vertebral and skull base malformations. Expression of myogenic growth factors, such as Pax3 and Myog, the growth factor Pdgfa, cadherin Cdh2, and the filament protein Des is abnormal. Mutants lack most or all of the epithelial organization seen in wild-type somites, sclerotome and dermomyotome. Mutants have disrupted production of matrix components including laminin-1 in the dermomyotome. Arrangement of the myogenic cells of the inter-limb somites is abnormal. Myf5 activation in the epaxial domain is retarded thus having consequences in the myogenesis by delaying expression of Myog. Mutants do not have left-right defects regarding internal organs positioning. Dmrt2 and Pax3 double null mutant embryos exhibit suspended development and Myog expression is markedly decreased and its expression pattern dramatically distorted. Belongs to the DMRT family. Sequence=AAD38425.1; Type=Miscellaneous discrepancy; Evidence=; Sequence=AAH27669.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE24347.1; Type=Frameshift; Evidence=; Sequence=CAB93343.1; Type=Frameshift; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of somitogenesis protein homodimerization activity sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding embryonic skeletal system development positive regulation of myotome development uc008hbm.1 uc008hbm.2 uc008hbm.3 uc008hbm.4 
ENSMUST00000053073.6 Pcdhb11 ENSMUST00000053073.6 protocadherin beta 11 (from RefSeq NM_053136.3) ENSMUST00000053073.1 ENSMUST00000053073.2 ENSMUST00000053073.3 ENSMUST00000053073.4 ENSMUST00000053073.5 NM_053136 Pcdhb11 Pcdhb5e Q91UZ8 Q91UZ8_MOUSE uc008epw.1 uc008epw.2 uc008epw.3 calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epw.1 uc008epw.2 uc008epw.3 
ENSMUST00000053078.5 Map10 ENSMUST00000053078.5 microtubule-associated protein 10 (from RefSeq NM_028908.3) ENSMUST00000053078.1 ENSMUST00000053078.2 ENSMUST00000053078.3 ENSMUST00000053078.4 Kiaa1383 MAP10_MOUSE NM_028908 Q5DTY2 Q8BJS7 uc009nyi.1 uc009nyi.2 uc009nyi.3 uc009nyi.4 Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis. Interacts (via middle region) with microtubules. Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody Note=Localized at stabilized microtubules (MTs) during interphase and to the mitotic apparatus during mitosis. Localized at spindle poles in metaphase and spindle midzone during telophase. Colocalized with Polo-like kinase PLK1 to the center of spindle midzone. Localized at the midbody during cytokinesis. Colocalized with acetylated-tubulin at MTs (By similarity). microtubule cytoskeleton organization spindle pole cytoplasm centrosome microtubule organizing center cytoskeleton cytoplasmic microtubule cell cycle microtubule binding midbody cytoplasmic microtubule organization positive regulation of cytokinesis regulation of microtubule-based process mitotic spindle midzone assembly cell division mitotic spindle pole mitotic spindle midzone uc009nyi.1 uc009nyi.2 uc009nyi.3 uc009nyi.4 
ENSMUST00000053086.3 Adam6a ENSMUST00000053086.3 a disintegrin and metallopeptidase domain 6A (from RefSeq NM_174885.3) Adam6 Adam6a B2RSY5 B2RSY5_MOUSE ENSMUST00000053086.1 ENSMUST00000053086.2 NM_174885 uc007pgw.1 uc007pgw.2 uc007pgw.3 Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function metalloendopeptidase activity proteolysis integrin-mediated signaling pathway biological_process metallopeptidase activity external side of plasma membrane cell surface membrane integral component of membrane macromolecular complex sperm head plasma membrane uc007pgw.1 uc007pgw.2 uc007pgw.3 
ENSMUST00000053087.4 Klhl23 ENSMUST00000053087.4 kelch-like 23, transcript variant 1 (from RefSeq NM_177784.4) A2AR06 ENSMUST00000053087.1 ENSMUST00000053087.2 ENSMUST00000053087.3 KLH23_MOUSE NM_177784 Q6GQU2 Q8C840 uc008jys.1 uc008jys.2 uc008jys.3 uc008jys.1 uc008jys.2 uc008jys.3 
ENSMUST00000053094.8 Mindy4 ENSMUST00000053094.8 MINDY lysine 48 deubiquitinase 4, transcript variant 1 (from RefSeq NM_001142781.1) ENSMUST00000053094.1 ENSMUST00000053094.2 ENSMUST00000053094.3 ENSMUST00000053094.4 ENSMUST00000053094.5 ENSMUST00000053094.6 ENSMUST00000053094.7 Fam188b MINY4_MOUSE NM_001142781 Q3UQI9 Q8C472 uc009cap.1 uc009cap.2 Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UQI9-1; Sequence=Displayed; Name=2; IsoId=Q3UQI9-2; Sequence=VSP_031672; Belongs to the MINDY deubiquitinase family. FAM188 subfamily. cellular_component proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity cysteine-type carboxypeptidase activity thiol-dependent ubiquitinyl hydrolase activity protein K48-linked deubiquitination Lys48-specific deubiquitinase activity uc009cap.1 uc009cap.2 
ENSMUST00000053106.7 Amigo2 ENSMUST00000053106.7 adhesion molecule with Ig like domain 2, transcript variant 3 (from RefSeq NM_001164602.1) AMGO2_MOUSE Ali1 Amigo2 ENSMUST00000053106.1 ENSMUST00000053106.2 ENSMUST00000053106.3 ENSMUST00000053106.4 ENSMUST00000053106.5 ENSMUST00000053106.6 NM_001164602 Q80ZD9 uc007xks.1 uc007xks.2 uc007xks.3 uc007xks.4 Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain (By similarity). Binds itself as well as AMIGO1 and AMIGO3. Cell membrane ; Single-pass type I membrane protein Nucleus Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity). Highest level in cerebellum, retina, liver, and lung. Lower levels in cerebrum, kidney, small intestine, spleen and testis. Belongs to the immunoglobulin superfamily. AMIGO family. molecular_function nucleus plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules brain development membrane integral component of membrane negative regulation of apoptotic process negative regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of synapse assembly uc007xks.1 uc007xks.2 uc007xks.3 uc007xks.4 
ENSMUST00000053107.6 Ivl ENSMUST00000053107.6 involucrin (from RefSeq NM_008412.3) ENSMUST00000053107.1 ENSMUST00000053107.2 ENSMUST00000053107.3 ENSMUST00000053107.4 ENSMUST00000053107.5 G3X9D9 G3X9D9_MOUSE Ivl NM_008412 uc008qef.1 uc008qef.2 uc008qef.3 uc008qef.4 Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Directly or indirectly cross-linked to cornifelin (CNFN). Cytoplasm Substrate of transglutaminase. Belongs to the involucrin family. cornified envelope cytoplasm keratinocyte differentiation keratinization uc008qef.1 uc008qef.2 uc008qef.3 uc008qef.4 
ENSMUST00000053109.5 Fbxo46 ENSMUST00000053109.5 F-box protein 46 (from RefSeq NM_175530.3) ENSMUST00000053109.1 ENSMUST00000053109.2 ENSMUST00000053109.3 ENSMUST00000053109.4 FBX46_MOUSE Fbx46 Fbxo34l NM_175530 Q8BG80 uc009fkt.1 uc009fkt.2 uc009fkt.3 uc009fkt.4 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Interacts with SKP1 and CUL1. molecular_function cellular_component biological_process uc009fkt.1 uc009fkt.2 uc009fkt.3 uc009fkt.4 
ENSMUST00000053144.4 Otos ENSMUST00000053144.4 otospiralin (from RefSeq NM_153114.2) ENSMUST00000053144.1 ENSMUST00000053144.2 ENSMUST00000053144.3 NM_153114 OTOSP_MOUSE Ocp10 Q8R448 uc007cbr.1 uc007cbr.2 May be essential for the survival of the neurosensory epithelium of the inner ear. Secreted Ear specific. Belongs to the otospiralin family. extracellular region sensory perception of sound uc007cbr.1 uc007cbr.2 
ENSMUST00000053149.4 Krtap13 ENSMUST00000053149.4 keratin associated protein 13 (from RefSeq NM_010671.1) ENSMUST00000053149.1 ENSMUST00000053149.2 ENSMUST00000053149.3 Krtap13 NM_010671 O88375 O88375_MOUSE uc007zvc.1 uc007zvc.2 uc007zvc.3 uc007zvc.4 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the PMG family. intermediate filament uc007zvc.1 uc007zvc.2 uc007zvc.3 uc007zvc.4 
ENSMUST00000053150.8 Rps27rt ENSMUST00000053150.8 ribosomal protein S27, retrogene (from RefSeq NM_001190258.1) ENSMUST00000053150.1 ENSMUST00000053150.2 ENSMUST00000053150.3 ENSMUST00000053150.4 ENSMUST00000053150.5 ENSMUST00000053150.6 ENSMUST00000053150.7 NM_001190258 Q3TLE3 Q6ZWU9 RS27_MOUSE Rps27 uc033jnn.1 uc033jnn.2 uc033jnn.3 Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Cytoplasm Nucleus, nucleolus Belongs to the eukaryotic ribosomal protein eS27 family. ribosomal small subunit assembly structural constituent of ribosome protein binding nucleus ribosome rRNA processing translation postsynaptic density cytosolic small ribosomal subunit metal ion binding uc033jnn.1 uc033jnn.2 uc033jnn.3 
ENSMUST00000053156.10 Ffar2 ENSMUST00000053156.10 free fatty acid receptor 2, transcript variant 1 (from RefSeq NM_146187.4) ENSMUST00000053156.1 ENSMUST00000053156.2 ENSMUST00000053156.3 ENSMUST00000053156.4 ENSMUST00000053156.5 ENSMUST00000053156.6 ENSMUST00000053156.7 ENSMUST00000053156.8 ENSMUST00000053156.9 FFAR2_MOUSE Gpr43 Lssig NM_146187 Q8VCK6 uc009ggn.1 uc009ggn.2 uc009ggn.3 G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin- sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine (PubMed:22190648, PubMed:23589301). May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake (PubMed:20399779). Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes (PubMed:16123168, PubMed:23589301). In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines (PubMed:23665276). May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils (PubMed:19917676, PubMed:19865172). In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL- 8 in response to the presence of microbes. Interacts with FCN1 (via Fibrinogen C-terminal domain). Cell membrane ; Multi-pass membrane protein Highly expressed in hematopoietic tissues, such as spleen and bone marrow, with highest levels in a subset of immune cells, including monocytes or neutrophils. Expressed in adipose tissues with high expression in differentiating adipocytes. Expressed by intestinal endocrine cells. During differentiation of leukocytes. This induction is STAT3-dependent. Up-regulated in adipose tissues by high-fat diet. Knockout mice display altered protective intestinal inflammatory and immune responses but no gross developmental defects. Belongs to the G-protein coupled receptor 1 family. leukocyte chemotaxis involved in inflammatory response immune system process mucosal immune response regulation of acute inflammatory response positive regulation of cytokine production involved in immune response cell surface pattern recognition receptor signaling pathway positive regulation of acute inflammatory response to non-antigenic stimulus G-protein coupled receptor activity plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway lipid binding membrane integral component of membrane lipid storage positive regulation of chemokine production glucose homeostasis cell projection fat cell differentiation cellular response to fatty acid regulation of peptide hormone secretion positive regulation of interleukin-8 secretion uc009ggn.1 uc009ggn.2 uc009ggn.3 
ENSMUST00000053157.7 Shisal2a ENSMUST00000053157.7 shisa like 2A (from RefSeq NM_001099303.2) A2A9G7 ENSMUST00000053157.1 ENSMUST00000053157.2 ENSMUST00000053157.3 ENSMUST00000053157.4 ENSMUST00000053157.5 ENSMUST00000053157.6 Fam159a NM_001099303 SHL2A_MOUSE uc008ubb.1 uc008ubb.2 uc008ubb.3 uc008ubb.4 Membrane ; Multi-pass membrane protein Belongs to the shisa family. molecular_function cellular_component biological_process membrane integral component of membrane uc008ubb.1 uc008ubb.2 uc008ubb.3 uc008ubb.4 
ENSMUST00000053175.13 Vstm4 ENSMUST00000053175.13 V-set and transmembrane domain containing 4, transcript variant 1 (from RefSeq NM_178791.5) ENSMUST00000053175.1 ENSMUST00000053175.10 ENSMUST00000053175.11 ENSMUST00000053175.12 ENSMUST00000053175.2 ENSMUST00000053175.3 ENSMUST00000053175.4 ENSMUST00000053175.5 ENSMUST00000053175.6 ENSMUST00000053175.7 ENSMUST00000053175.8 ENSMUST00000053175.9 NM_178791 T1NXB5 VSTM4_MOUSE uc007szj.1 uc007szj.2 uc007szj.3 Peptide Lv enhances L-type voltage-gated calcium channel (L- VGCC) currents in retinal photoreceptors. Cell membrane ; Single-pass type I membrane protein [Peptide Lv]: Secreted Peptide Lv is widely expressed in various tissues and the central nervous system, including the retinal photoreceptor layer, hippocampus, olfactory bulb, and cerebellum. Proteolytically cleaved to generate a bioactive peptide. [Peptide Lv]: Mass=5808.66; Method=MALDI; Evidence=; protein binding extracellular region plasma membrane biological_process membrane integral component of membrane uc007szj.1 uc007szj.2 uc007szj.3 
ENSMUST00000053177.14 Wdfy3 ENSMUST00000053177.14 WD repeat and FYVE domain containing 3 (from RefSeq NM_172882.3) ENSMUST00000053177.1 ENSMUST00000053177.10 ENSMUST00000053177.11 ENSMUST00000053177.12 ENSMUST00000053177.13 ENSMUST00000053177.2 ENSMUST00000053177.3 ENSMUST00000053177.4 ENSMUST00000053177.5 ENSMUST00000053177.6 ENSMUST00000053177.7 ENSMUST00000053177.8 ENSMUST00000053177.9 NM_172882 Q6VNB8 Q8C8H7 WDFY3_MOUSE uc008yis.1 uc008yis.2 uc008yis.3 uc008yis.4 Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5- ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures) (By similarity). Important for normal brain development (PubMed:25198012, PubMed:27648578). Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (PubMed:27648578). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (By similarity). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (PubMed:27330028). After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (By similarity). Directly interacts with ATG5 and associates with the ATG12- ATG5-ATG16L complex. Interacts with p62/SQSTM1. Directly interacts with GABARAP, GABARAPL1 and GABARAPL2; the interaction with GABARAP is required for WDFY3 recruitment to MAP1LC3B-positive p62/SQSTM1 bodies. Weakly interacts with MAP1LC3C; this interaction is direct. Does not interact with MAP1LC3A, nor MAP1LC3B (By similarity). Interacts with TRAF6 (PubMed:27330028). Nucleus Cytoplasm, cytosol cleus, PML body Membrane ; Peripheral membrane protein ; Cytoplasmic side Perikaryon Cell projection, axon Note=Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures. This redistribution is dependent on p62/SQSTM1. When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or partially colocalize with promyelocytic leukemia (PML) bodies (By similarity). Localizes throughout neurons, including within axons. In neurons, enriched in the light membrane fraction along with the synaptosomal membrane protein synaptophysin and the membrane-bound form of LC3/MAP1LC3A/MAP1LC3B, called LC3-II, a classic marker for autophagic vesicles (PubMed:27648578). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=a ; IsoId=Q6VNB8-1; Sequence=Displayed; Name=2; IsoId=Q6VNB8-2; Sequence=VSP_019477, VSP_019478; Widely expressed, with high levels in the brain (at protein level) (PubMed:15342963, PubMed:15292400, PubMed:27648578). In the brain, expressed by both neuronal and non-neuronal cells (PubMed:27648578). Expressed in bones, in the periosteum, cartilage, growth plate, trabeculae of the primary spongiosa, and scattered hematopoietic cells within the medullary cavity. Tends to be expressed at lower levels in the hypertrophic zone compared to trabeculae. Expressed in osteoblasts, osteoclasts and bone-marrow derived macrophages (PubMed:27330028). Detected in the developing central nervous system already at 11.5 dpc (PubMed:27648578). At 13.5 dpc, strong expression in the proliferative zones surrounding the lateral ventricle and weaker expression throughout the developing forebrain. At 14.5 dpc, highest expression within the proliferative regions surrounding the ventricles. Specifically expressed in the leptomeninges, cortical intermediate zone, choroid plexus and in radial glia cells within the ventricular zone (VZ). Within the VZ, expression is observed in a subset of cells actively undergoing mitosis. The expression persists through all phases of cell division, but decreases during telophase. Expression is often maintained in radial units, where it is the highest in progenitors closest to the ventricle, then gradually diminishes as distance from the ventricular surface increases (PubMed:15342963, PubMed:25198012). Expression levels in the brain decrease after birth (at protein level) (PubMed:15342963). The LIR (LC3-interacting region) motif mediates the interaction with MAP1LC3C and other ATG8 family members. The FYVE domain mediates binding to phosphatidylinositol 3- phosphate (PtdIns3P). Homozygous mice are born at close to the expected Mendelian ratios, but die perinatally (PubMed:25198012, PubMed:27648578). Newborn animals exhibit striking abnormalities in the forebrain, midbrain and hindbrain, including visibly smaller brains and gross enlargement of the lateral ventricles. There is an apparent loss and disorganization of interhemispheric axonal tracts throughout the brain (PubMed:25198012, PubMed:27648578). Sequence=BAC32952.1; Type=Frameshift; Evidence=; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity 1-phosphatidylinositol binding nucleus nuclear envelope nucleolus cytoplasm autophagosome cytosol plasma membrane autophagy multicellular organism development lipid binding membrane inclusion body PML body extrinsic component of membrane axon Atg12-Atg5-Atg16 complex aggrephagy cell projection perikaryon metal ion binding extrinsic component of autophagosome membrane uc008yis.1 uc008yis.2 uc008yis.3 uc008yis.4 
ENSMUST00000053180.4 Defb19 ENSMUST00000053180.4 defensin beta 19 (from RefSeq NM_145157.3) DFB19_MOUSE Defb24 ENSMUST00000053180.1 ENSMUST00000053180.2 ENSMUST00000053180.3 NM_145157 Q3V0L7 Q8K3I8 Tdl uc008nfs.1 uc008nfs.2 Has antibacterial activity. Secreted Specifically expressed in male gonads (Sertoli cells). Not detected at 11.5 dpc. Specific signals are observed within seminiferous cords in male gonads at 12.5, 13.5, 14.5, and 16.5 dpc and in newborn testes. In 16.5 and newborn testes, its expression is also found in epididymis. No specific signal is found in female gonads. Belongs to the beta-defensin family. lipopolysaccharide binding extracellular region defense response defense response to bacterium innate immune response defense response to Gram-negative bacterium defense response to Gram-positive bacterium antifungal innate immune response uc008nfs.1 uc008nfs.2 
ENSMUST00000053183.12 Arf3 ENSMUST00000053183.12 ADP-ribosylation factor 3, transcript variant 1 (from RefSeq NM_007478.3) Arf3 ENSMUST00000053183.1 ENSMUST00000053183.10 ENSMUST00000053183.11 ENSMUST00000053183.2 ENSMUST00000053183.3 ENSMUST00000053183.4 ENSMUST00000053183.5 ENSMUST00000053183.6 ENSMUST00000053183.7 ENSMUST00000053183.8 ENSMUST00000053183.9 NM_007478 Q3U344 Q3U344_MOUSE uc007xnp.1 uc007xnp.2 uc007xnp.3 GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus. GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at the Golgi complex. Golgi apparatus Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTP binding retrograde vesicle-mediated transport, Golgi to ER uc007xnp.1 uc007xnp.2 uc007xnp.3 
ENSMUST00000053202.12 Rhbdl2 ENSMUST00000053202.12 rhomboid like 2, transcript variant 1 (from RefSeq NM_183163.3) A2AGA4 ENSMUST00000053202.1 ENSMUST00000053202.10 ENSMUST00000053202.11 ENSMUST00000053202.2 ENSMUST00000053202.3 ENSMUST00000053202.4 ENSMUST00000053202.5 ENSMUST00000053202.6 ENSMUST00000053202.7 ENSMUST00000053202.8 ENSMUST00000053202.9 NM_183163 RHBL2_MOUSE uc008upx.1 uc008upx.2 Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3 (By similarity). Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; Evidence=; [Rhomboid-related protein 2, C-terminal fragment]: Cell membrane ; Multi-pass membrane protein Proteolytic processing of the proenzyme produces an N- and a C- terminal fragment. The processing is required for activation of the protease (By similarity). Belongs to the peptidase S54 family. serine-type endopeptidase activity plasma membrane proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc008upx.1 uc008upx.2 
ENSMUST00000053211.8 Mfsd6l ENSMUST00000053211.8 major facilitator superfamily domain containing 6-like (from RefSeq NM_146004.1) ENSMUST00000053211.1 ENSMUST00000053211.2 ENSMUST00000053211.3 ENSMUST00000053211.4 ENSMUST00000053211.5 ENSMUST00000053211.6 ENSMUST00000053211.7 MFS6L_MOUSE NM_146004 Q8R3N2 uc007jnv.1 uc007jnv.2 Membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. MFSD6 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007jnv.1 uc007jnv.2 
ENSMUST00000053215.14 Pik3cg ENSMUST00000053215.14 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma, transcript variant 3 (from RefSeq NM_001146200.2) ENSMUST00000053215.1 ENSMUST00000053215.10 ENSMUST00000053215.11 ENSMUST00000053215.12 ENSMUST00000053215.13 ENSMUST00000053215.2 ENSMUST00000053215.3 ENSMUST00000053215.4 ENSMUST00000053215.5 ENSMUST00000053215.6 ENSMUST00000053215.7 ENSMUST00000053215.8 ENSMUST00000053215.9 NM_001146200 PK3CG_MOUSE Pi3kg1 Q80V09 Q9JHG7 uc007nic.1 uc007nic.2 uc007nic.3 uc007nic.4 Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T- lymphocyte proliferation, activation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B- lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non- muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contribute to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+); Xref=Rhea:RHEA:12709, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088, ChEBI:CHEBI:456216; EC=2.7.1.137; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12710; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+); Xref=Rhea:RHEA:21292, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57836, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.153; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21293; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:18373, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57658, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216; EC=2.7.1.154; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18374; Evidence=; Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Activated by both the alpha and the beta-gamma G proteins following stimulation of G protein-coupled receptors (GPCRs). Activation by GPCRs is assisted by the regulatory subunit PIK3R5 leading to the translocation from the cytosol to the plasma membrane and to kinase activation; the respective activation involving PIK3R6 requires HRAS for membrane recruitment. Wortmannin sensitive in nM range. Inhibited by AS252424. Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. Heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. Interacts with GRK2 through the PIK helical domain (By similarity). Interaction with GRK2 is required for targeting to agonist-occupied receptor. Interacts with PDE3B; regulates PDE3B activity and thereby cAMP levels in cells (PubMed:15294162). Interacts with TPM2 (By similarity). Interacts with EPHA8; regulates integrin- mediated cell adhesion to substrate. Interacts with HRAS; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6. Q9JHG7; Q3U6Q4: Pik3r6; NbExp=4; IntAct=EBI-644372, EBI-4303950; Cytoplasm Cell membrane Phosphorylated at Thr-1024 by PKA. Phosphorylation inhibits lipid kinase activity. Autophosphorylation at Ser-1101 has no effect on the phosphatidylinositol-4,5-bisphosphate 3-kinase activity. PIK3CG-null mice are viable and fertile, and display immunological abnormalities when the immune system is stressed. There is reduced T(reg) cells amount, reduced levels of IgG, enhanced IL12 production in macrophages, and increased T-cell infiltration in the gut (PubMed:31554793). Leukocyte migration in response to chemotactic agents and towards the site of inflammation, as well as neutrophil oxidative burst in response to chemotactic agents are decreased. Mutant mice show reduced thymocyte survival, defective T lymphocyte activation, and are protected from leukocyte infiltration of synovia in a model of rheumatoid arthritis. Dendritic cell showed reduced response to chemokines and migration to draining lymph nodes under inflammatory conditions. Platelets have defects in thrombus formation. PIK3CG-null mice show increased cardiac contractility, and display myocardial damage after transverse aortic constriction. Belongs to the PI3/PI4-kinase family. nucleotide binding angiogenesis regulation of protein phosphorylation immune system process positive regulation of acute inflammatory response protein serine/threonine kinase activity protein binding ATP binding cytoplasm cytosol plasma membrane phosphatidylinositol 3-kinase complex phosphatidylinositol 3-kinase complex, class IB protein phosphorylation endocytosis chemotaxis inflammatory response G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration negative regulation of triglyceride catabolic process phosphatidylinositol 3-kinase signaling membrane kinase activity 1-phosphatidylinositol-3-kinase activity phosphorylation transferase activity secretory granule localization 1-phosphatidylinositol-4-phosphate 3-kinase activity phosphatidylinositol-3-phosphate biosynthetic process identical protein binding positive regulation of catalytic activity positive regulation of MAP kinase activity phosphatidylinositol phosphorylation ephrin receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphatidylinositol-mediated signaling positive regulation of protein kinase B signaling phosphatidylinositol-3,4-bisphosphate 5-kinase activity cellular response to cAMP hepatocyte apoptotic process regulation of calcium ion transmembrane transport negative regulation of fibroblast apoptotic process uc007nic.1 uc007nic.2 uc007nic.3 uc007nic.4 
ENSMUST00000053218.7 Dact2 ENSMUST00000053218.7 dishevelled-binding antagonist of beta-catenin 2 (from RefSeq NM_172826.3) DACT2_MOUSE Dpr2 ENSMUST00000053218.1 ENSMUST00000053218.2 ENSMUST00000053218.3 ENSMUST00000053218.4 ENSMUST00000053218.5 ENSMUST00000053218.6 Frd2 NM_172826 Q6PDF4 Q7TN08 Q8BHZ7 uc008amv.1 uc008amv.2 uc008amv.3 uc008amv.4 Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling. Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, CSNK2B, DVL1, DVL2, DVL3, VANGL1, VANGL2, TGFBR1, CTNNB1, CTNND2, CTNND1, LEF1, TCF7, TCF7L1 and HDAC1. Q7TN08; Q0PHV7: Dact3; NbExp=2; IntAct=EBI-6392494, EBI-6392520; Expressed in kidney (inner medullary collecting duct). Expressed in epidermal keratinocytes and hair follicles. Expressed throughout the epiblast at the onset of gastrulation and in somites, the neural tube and gut at later stages of development. In the developing kidney is expressed in the ureteric bud/collecting duct epithelium. The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins. Involved in non-canonical Wnt signaling only when massively overexpressed. Belongs to the dapper family. Sequence=BAC31003.1; Type=Frameshift; Evidence=; hematopoietic progenitor cell differentiation epithelial cell morphogenesis protein kinase C binding protein binding cytoplasm mitochondrion negative regulation of cell adhesion multicellular organism development beta-catenin binding transcription factor binding regulation of Wnt signaling pathway skin development protein kinase A binding delta-catenin binding inner medullary collecting duct development negative regulation of nodal signaling pathway uc008amv.1 uc008amv.2 uc008amv.3 uc008amv.4 
ENSMUST00000053225.7 Olig3 ENSMUST00000053225.7 oligodendrocyte transcription factor 3 (from RefSeq NM_053008.3) Bhlhb7 ENSMUST00000053225.1 ENSMUST00000053225.2 ENSMUST00000053225.3 ENSMUST00000053225.4 ENSMUST00000053225.5 ENSMUST00000053225.6 NM_053008 OLIG3_MOUSE Q6PFG8 Q9EQW5 uc007ene.1 uc007ene.2 uc007ene.3 May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons. Nucleus Weakly expressed, mainly in non-neural tissues. Restricted to the CNS. At 9.25 and 10.5 dpc, specifically expressed in the dorsal neural tube from the midbrain/hindbrain boundary to the spinal cord. At 10.5 dpc, expressed continuously from the upper rhombic lip to the tail. From 10.5 to 12.5 dpc, located in the most dorsal aspect of the spinal cord, excluding the roof plate, mainly in proliferating progenitor cells; quickly down- regulated in postmitotic neurons. At 11.5 dpc, 3 ventral expression clusters, corresponding to p3, p2 and p0 domains, transiently appear on the lateral margin of the subventricular zone, in addition to dorsal expression. At 14.5 dpc, weakly expressed in cells scattered in the mantle zone. Expression declines after 15.5 dpc. In the 11.5 dpc forebrain, expressed in the ventricular zone of the dorsal thalamus. In the 11.5 to 14.5 dpc hindbrain, dorsally expressed in the upper and lower rhombic lip, in the cerebellar neuroepithelium. Sequence=BAB18908.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter DNA binding transcription corepressor activity nucleus regulation of transcription, DNA-templated regulation of gene expression spinal cord motor neuron cell fate specification spinal cord motor neuron differentiation protein dimerization activity spinal cord motor neuron migration uc007ene.1 uc007ene.2 uc007ene.3 
ENSMUST00000053230.7 Ulk3 ENSMUST00000053230.7 unc-51-like kinase 3 (from RefSeq NM_027895.1) B2RXB9 ENSMUST00000053230.1 ENSMUST00000053230.2 ENSMUST00000053230.3 ENSMUST00000053230.4 ENSMUST00000053230.5 ENSMUST00000053230.6 NM_027895 Q3U3Q1 Q8K1X6 Q9DBR8 ULK3_MOUSE uc009pvf.1 uc009pvf.2 uc009pvf.3 Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts (via protein kinase domain) with SUFU. Cytoplasm Note=Localizes to pre- autophagosomal structure during cellular senescence. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U3Q1-1; Sequence=Displayed; Name=2; IsoId=Q3U3Q1-2; Sequence=VSP_020604; Name=3; IsoId=Q3U3Q1-3; Sequence=VSP_020602, VSP_020603; Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU (By similarity). Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Sequence=AAH37093.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm protein phosphorylation autophagy kinase activity phosphorylation transferase activity negative regulation of smoothened signaling pathway positive regulation of smoothened signaling pathway protein autophosphorylation uc009pvf.1 uc009pvf.2 uc009pvf.3 
ENSMUST00000053239.4 Sstr3 ENSMUST00000053239.4 somatostatin receptor 3, transcript variant 1 (from RefSeq NM_009218.3) ENSMUST00000053239.1 ENSMUST00000053239.2 ENSMUST00000053239.3 NM_009218 P30935 Q0VB04 Q3UVV5 SSR3_MOUSE Smstr3 uc007wpo.1 uc007wpo.2 uc007wpo.3 Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function (By similarity). Cell membrane ; Multi-pass membrane protein Note=Internalized into endoplasmic vesicles upon somatostatin-stimulation. In the brain, primarily observed in the forebrain. Moderate levels found throughout laminae 2-6 of the neocortex and allocortex, and high levels in lamina 2 of the piriform and entorhinal cortices. High levels also present in the cornu ammonis fields of the hippocampus. In the amygdala, highly expressed in the nucleus of the lateral olfactory tract with expression also detected in the rostral portions of the basal magnocellular and lateral nuclei. In the diencephalon, moderate levels observed in the ventromedial and arcuate nuclei of the hypothalamus. In the midbrain, moderate levels found in the lateral portion of the substantia nigra pars reticulata. Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity somatostatin receptor activity receptor binding cytoplasm plasma membrane integral component of plasma membrane cilium signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway spermatogenesis membrane integral component of membrane cerebellum development forebrain development somatostatin signaling pathway peptide binding response to starvation neuropeptide binding ciliary membrane cellular response to glucocorticoid stimulus cellular response to estradiol stimulus non-motile cilium uc007wpo.1 uc007wpo.2 uc007wpo.3 
ENSMUST00000053249.9 Ftdc2 ENSMUST00000053249.9 ferritin domain containing 2 (from RefSeq NM_175011.2) E330017A01Rik ENSMUST00000053249.1 ENSMUST00000053249.2 ENSMUST00000053249.3 ENSMUST00000053249.4 ENSMUST00000053249.5 ENSMUST00000053249.6 ENSMUST00000053249.7 ENSMUST00000053249.8 Ftdc Ftdc2 NM_175011 Q8BU47 Q8BU47_MOUSE uc007zny.1 uc007zny.2 uc007zny.3 Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. ferroxidase activity iron ion binding cytoplasm iron ion transport cellular iron ion homeostasis intracellular sequestering of iron ion ferrous iron binding ferric iron binding identical protein binding metal ion binding oxidation-reduction process uc007zny.1 uc007zny.2 uc007zny.3 
ENSMUST00000053250.5 Clrn2 ENSMUST00000053250.5 clarin 2 (from RefSeq NM_001163317.2) B2RVW2 CLRN2_MOUSE Clrn2 ENSMUST00000053250.1 ENSMUST00000053250.2 ENSMUST00000053250.3 ENSMUST00000053250.4 NM_001163317 uc012dvy.1 uc012dvy.2 Plays a key role to hearing function. Required for normal organization and maintenance of the stereocilia bundle and for mechano- electrical transduction. Cell projection, stereocilium membrane ; Multi-pass membrane protein Detected in inner ear, particularly in hair bundles of auditory hair cells and is enriched in apical stereocilia. Detected in eye, but not in brain or muscle. Expression in the cochlea is stable from late embryonic stages to P12 (the onset of hearing in mice), but thereafter increases. Mice homozygous for an ENU-induced allele exhibit an early-onset, progressive hearing loss, with a lack of fast-graded voltage responses. These mice harbor an early truncating nonsense variant (Trp4Ter). By postnatal days 6 (P6), mutants do not exhibit any gross patterning defects, or differences in the overall number of outer hair cells (OHC) and inner hair cells (IHC) bundles compared to controls. However, despite normal shape organization, these mice shown a progressive reduction in height of the middle and shortest row stereocilia, which is evident first in OHCs by P8, and then later in IHCs at P16. Belongs to the clarin family. molecular_function cellular_component biological_process membrane integral component of membrane uc012dvy.1 uc012dvy.2 
ENSMUST00000053251.12 Rbpms ENSMUST00000053251.12 RNA binding protein gene with multiple splicing, transcript variant 2 (from RefSeq NM_001042674.2) ENSMUST00000053251.1 ENSMUST00000053251.10 ENSMUST00000053251.11 ENSMUST00000053251.2 ENSMUST00000053251.3 ENSMUST00000053251.4 ENSMUST00000053251.5 ENSMUST00000053251.6 ENSMUST00000053251.7 ENSMUST00000053251.8 ENSMUST00000053251.9 Hermes NM_001042674 Q78HG1 Q9CPU5 Q9WVB0 RBPMS_MOUSE uc009lkl.1 uc009lkl.2 uc009lkl.3 uc009lkl.4 Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA. Homodimer; each protein chain binds one RNA molecule via the external surface of the homodimer. Interacts with SMAD2, SMAD3 and SMAD4; the interactions are direct. Nucleus Cytoplasm Cytoplasm, P-body Note=Translocates into cytoplasmic stress granules that probably correspond to P-bodies in response to oxidative stress. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WVB0-1; Sequence=Displayed; Name=2; IsoId=Q9WVB0-2; Sequence=VSP_045747; mRNA expressed in developing heart, with significantly higher expression in the atria relative to the ventricles. mRNA already detected at 9.5 dpc. The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity (By similarity). P-body nucleic acid binding transcription coactivator activity RNA binding mRNA binding nucleus nucleoplasm cytoplasm cytosol response to oxidative stress poly(A) binding cytoplasmic stress granule positive regulation of pathway-restricted SMAD protein phosphorylation protein homodimerization activity positive regulation of SMAD protein import into nucleus positive regulation of nucleic acid-templated transcription uc009lkl.1 uc009lkl.2 uc009lkl.3 uc009lkl.4 
ENSMUST00000053252.9 Ctxn1 ENSMUST00000053252.9 cortexin 1 (from RefSeq NM_183315.2) CTXN1_MOUSE Ctxn ENSMUST00000053252.1 ENSMUST00000053252.2 ENSMUST00000053252.3 ENSMUST00000053252.4 ENSMUST00000053252.5 ENSMUST00000053252.6 ENSMUST00000053252.7 ENSMUST00000053252.8 NM_183315 Q8K129 uc009ktp.1 uc009ktp.2 uc009ktp.3 uc009ktp.4 May mediate extracellular or intracellular signaling of cortical neurons during forebrain development. Membrane ; Single-pass membrane protein Belongs to the cortexin family. molecular_function cellular_component biological_process membrane integral component of membrane uc009ktp.1 uc009ktp.2 uc009ktp.3 uc009ktp.4 
ENSMUST00000053253.10 Vmn2r13 ENSMUST00000053253.10 vomeronasal 2, receptor 13, transcript variant 1 (from RefSeq NM_001384974.1) ENSMUST00000053253.1 ENSMUST00000053253.2 ENSMUST00000053253.3 ENSMUST00000053253.4 ENSMUST00000053253.5 ENSMUST00000053253.6 ENSMUST00000053253.7 ENSMUST00000053253.8 ENSMUST00000053253.9 L7N1X2 L7N1X2_MOUSE NM_001384974 Vmn2r13 uc009vdk.1 uc009vdk.2 uc009vdk.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vdk.1 uc009vdk.2 uc009vdk.3 
ENSMUST00000053257.10 Speer4b ENSMUST00000053257.10 spermatogenesis associated glutamate (E)-rich protein 4B (from RefSeq NM_028561.2) ENSMUST00000053257.1 ENSMUST00000053257.2 ENSMUST00000053257.3 ENSMUST00000053257.4 ENSMUST00000053257.5 ENSMUST00000053257.6 ENSMUST00000053257.7 ENSMUST00000053257.8 ENSMUST00000053257.9 NM_028561 Q9D9F7 Q9D9F7_MOUSE Speer4b uc008wtp.1 uc008wtp.2 uc008wtp.3 uc008wtp.4 molecular_function cellular_component biological_process uc008wtp.1 uc008wtp.2 uc008wtp.3 uc008wtp.4 
ENSMUST00000053263.9 Tmem82 ENSMUST00000053263.9 transmembrane protein 82, transcript variant 1 (from RefSeq NM_145987.2) A2ADF5 ENSMUST00000053263.1 ENSMUST00000053263.2 ENSMUST00000053263.3 ENSMUST00000053263.4 ENSMUST00000053263.5 ENSMUST00000053263.6 ENSMUST00000053263.7 ENSMUST00000053263.8 NM_145987 Q8R115 TMM82_MOUSE uc008vou.1 uc008vou.2 uc008vou.3 Membrane ; Multi-pass membrane protein Belongs to the TMEM82 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008vou.1 uc008vou.2 uc008vou.3 
ENSMUST00000053265.8 Lyrm4 ENSMUST00000053265.8 LYR motif containing 4 (from RefSeq NM_201358.3) ENSMUST00000053265.1 ENSMUST00000053265.2 ENSMUST00000053265.3 ENSMUST00000053265.4 ENSMUST00000053265.5 ENSMUST00000053265.6 ENSMUST00000053265.7 Isd11 LYRM4_MOUSE Lyrm4 NM_201358 Q8K215 uc007qcj.1 uc007qcj.2 uc007qcj.3 Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May also participates in the iron- sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1 (By similarity). Cofactor biosynthesis; iron-sulfur cluster biosynthesis. Homodimer. Component of the mitochondrial core iron-sulfur cluster (ISC) complex composed of NFS1, LYRM4, NDUFAB1, ISCU, FXN, and FDX2; this complex is an heterohexamer containing two copies of each monomer (By similarity). Component of the cyteine desulfurase complex composed of NFS1, LYRM4 and NDUFAB1; this complex contributes to the stability and cysteine desulfurase activity of NFS1. Interacts with FXN; this interaction is nickel-dependent. Interacts with the cytoplasmic form of NFS1; the complex increases the stability of NFS1. Forms a complex with the cytoplasmic form of NFS1; this complex increases the stability and cysteine desulfurase activity of NFS1. Interacts with NFS1 (By similarity). Component of a complex composed of FXN, NFS1, LYRM4 and ISCU (PubMed:21298097, PubMed:25597503). Mitochondrion Nucleus Belongs to the complex I LYR family. molecular_function nucleus mitochondrion biological_process nuclear body uc007qcj.1 uc007qcj.2 uc007qcj.3 
ENSMUST00000053266.11 Mcm3 ENSMUST00000053266.11 minichromosome maintenance complex component 3 (from RefSeq NM_008563.3) ENSMUST00000053266.1 ENSMUST00000053266.10 ENSMUST00000053266.2 ENSMUST00000053266.3 ENSMUST00000053266.4 ENSMUST00000053266.5 ENSMUST00000053266.6 ENSMUST00000053266.7 ENSMUST00000053266.8 ENSMUST00000053266.9 Mcm3 NM_008563 Q3UI57 Q3UI57_MOUSE uc007alc.1 uc007alc.2 uc007alc.3 Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Component of the MCM2-7 complex. Chromosome Nucleus Belongs to the MCM family. nucleotide binding DNA binding DNA helicase activity helicase activity ATP binding nucleus nucleoplasm centrosome DNA replication DNA replication initiation hydrolase activity DNA duplex unwinding MCM complex perinuclear region of cytoplasm uc007alc.1 uc007alc.2 uc007alc.3 
ENSMUST00000053273.15 Itpr2 ENSMUST00000053273.15 inositol 1,4,5-triphosphate receptor 2, transcript variant 1 (from RefSeq NM_019923.4) B2KF91 ENSMUST00000053273.1 ENSMUST00000053273.10 ENSMUST00000053273.11 ENSMUST00000053273.12 ENSMUST00000053273.13 ENSMUST00000053273.14 ENSMUST00000053273.2 ENSMUST00000053273.3 ENSMUST00000053273.4 ENSMUST00000053273.5 ENSMUST00000053273.6 ENSMUST00000053273.7 ENSMUST00000053273.8 ENSMUST00000053273.9 ITPR2_MOUSE Itpr5 NM_019923 P70226 Q5DWM3 Q5DWM5 Q61744 Q8R3B0 Q9Z329 uc009erw.1 uc009erw.2 uc009erw.3 uc009erw.4 Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. Isoform 3 has neither inositol 1,4,5-trisphosphate binding activity nor calcium releasing activity. Homotetramer. Interacts with CABP1. Interacts with BOK; regulates ITPR2 expression. Interacts with BCL2L10 (By similarity). Interacts with TRPC4 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=Q9Z329-1; Sequence=Displayed; Name=2; Synonyms=Short, TIPR; IsoId=Q9Z329-2; Sequence=VSP_002701, VSP_002702; Name=3; Synonyms=Itpr2v; IsoId=Q9Z329-3; Sequence=VSP_016026; Isoforms 1 and 3 are widely expressed. Isoform 2 is found in skeletal muscle and heart. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. There is a 3-fold reduction in the number of pilocarpine-responsive sweat glands in knockout animals. The sweat glands of these animals show a significant reduction in Ca(2+) response following acetylcholine stimulation compared with those of wild-type animals. The Itpr2-null animals retained some residual sweat production, in contrast to the human phenotype of anhidrosis. This phenotypic discrepancy may be due to differences between humans and mice in the expression of the 3 ITPR isoforms, as well as to the different stimuli used to provoke sweat production in Itpr2-null animals. Belongs to the InsP3 receptor family. response to hypoxia ion channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity calcium channel activity calcium ion binding protein binding nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane cell cortex ion transport calcium ion transport calcium-release channel activity membrane integral component of membrane sarcoplasmic reticulum axon cytoplasmic vesicle membrane secretory granule membrane sarcoplasmic reticulum membrane phosphatidylinositol binding myelin sheath receptor complex inositol phosphate-mediated signaling release of sequestered calcium ion into cytosol transmembrane transport calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding cellular response to cAMP cellular response to ethanol scaffold protein binding uc009erw.1 uc009erw.2 uc009erw.3 uc009erw.4 
ENSMUST00000053286.9 Cenatac ENSMUST00000053286.9 centrosomal AT-AC splicing factor, transcript variant 2 (from RefSeq NR_151775.1) CATAC_MOUSE Ccdc84 ENSMUST00000053286.1 ENSMUST00000053286.2 ENSMUST00000053286.3 ENSMUST00000053286.4 ENSMUST00000053286.5 ENSMUST00000053286.6 ENSMUST00000053286.7 ENSMUST00000053286.8 NR_151775 Q3TAL6 Q4VA36 Q7TNQ4 Q8C702 uc009pdo.1 uc009pdo.2 uc009pdo.3 uc009pdo.4 Component of the minor spliceosome that promotes splicing of a specific, rare minor intron subtype. Negative regulator of centrosome duplication. Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1. Interacts with SASS6; the interaction increases with CENATAC acetylation. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q4VA36-1; Sequence=Displayed; Name=2; IsoId=Q4VA36-2; Sequence=VSP_022266, VSP_022267; Name=3; IsoId=Q4VA36-3; Sequence=VSP_022268, VSP_022269; Acetylated. Acetylation oscillates throughout the cell cycle, and the acetylation state at Lys-31 is regulated by the deacetylase SIRT1 and the acetyltransferase NAT10. Deacetylated CENATAC is responsible for its centrosome targeting, and acetylated CENATAC promotes SASS6 degradation by enhancing the binding affinity of SASS6 for APC/C E3 ubiquitin-protein ligase complex/FZR1. Sequence=AAH55929.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process uc009pdo.1 uc009pdo.2 uc009pdo.3 uc009pdo.4 
ENSMUST00000053287.6 Usp42 ENSMUST00000053287.6 ubiquitin specific peptidase 42 (from RefSeq NM_029749.2) B2RQC2 ENSMUST00000053287.1 ENSMUST00000053287.2 ENSMUST00000053287.3 ENSMUST00000053287.4 ENSMUST00000053287.5 NM_029749 UBP42_MOUSE uc009akp.1 uc009akp.2 uc009akp.3 Deubiquitinating enzyme which may play an important role during spermatogenesis. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Highest expression seen in the testis. Also expressed in brain, lung and thymus. The expression level gradually increases from 2 weeks after birth and then decreases from the pachytene spermatocyte (PS) stage during spermatogenesis. Expressed in the midbrain, forebrain, optic vesicles and eyes of embryos at 10.5 dpc and a more pronounced expression is seen at 12.5 dpc. Belongs to the peptidase C19 family. cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity cellular_component proteolysis ubiquitin-dependent protein catabolic process spermatogenesis peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity cell differentiation thiol-dependent ubiquitinyl hydrolase activity regulation of apoptotic process uc009akp.1 uc009akp.2 uc009akp.3 
ENSMUST00000053288.6 Cdr2l ENSMUST00000053288.6 cerebellar degeneration-related protein 2-like (from RefSeq NM_001080929.1) A2A6T1 CDR2L_MOUSE ENSMUST00000053288.1 ENSMUST00000053288.2 ENSMUST00000053288.3 ENSMUST00000053288.4 ENSMUST00000053288.5 Gm21 NM_001080929 uc007mhi.1 uc007mhi.2 Belongs to the CDR2 family. molecular_function cellular_component biological_process uc007mhi.1 uc007mhi.2 
ENSMUST00000053290.8 Or4n5 ENSMUST00000053290.8 olfactory receptor family 4 subfamily N member 5 (from RefSeq NM_146494.2) ENSMUST00000053290.1 ENSMUST00000053290.2 ENSMUST00000053290.3 ENSMUST00000053290.4 ENSMUST00000053290.5 ENSMUST00000053290.6 ENSMUST00000053290.7 NM_146494 Olfr722 Or4n5 Q8VFC8 Q8VFC8_MOUSE uc007tkl.1 uc007tkl.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: BC051403.1, BQ892162.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007tkl.1 uc007tkl.2 
ENSMUST00000053304.10 Pramel32 ENSMUST00000053304.10 PRAME like 32, transcript variant 1 (from RefSeq NM_198663.3) C87499 ENSMUST00000053304.1 ENSMUST00000053304.2 ENSMUST00000053304.3 ENSMUST00000053304.4 ENSMUST00000053304.5 ENSMUST00000053304.6 ENSMUST00000053304.7 ENSMUST00000053304.8 ENSMUST00000053304.9 NM_198663 Pramel32 Q3UX49 Q3UX49_MOUSE uc008tne.1 uc008tne.2 uc008tne.3 uc008tne.4 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008tne.1 uc008tne.2 uc008tne.3 uc008tne.4 
ENSMUST00000053306.8 Oxtr ENSMUST00000053306.8 oxytocin receptor, transcript variant 1 (from RefSeq NM_001081147.3) ENSMUST00000053306.1 ENSMUST00000053306.2 ENSMUST00000053306.3 ENSMUST00000053306.4 ENSMUST00000053306.5 ENSMUST00000053306.6 ENSMUST00000053306.7 F8VQ78 NM_001081147 OXYR_MOUSE P97926 uc009deb.1 uc009deb.2 uc009deb.3 uc009deb.4 Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. suckling behavior response to amphetamine regulation of systemic arterial blood pressure by vasopressin G-protein coupled receptor activity oxytocin receptor activity vasopressin receptor activity plasma membrane integral component of plasma membrane microvillus cell-cell adherens junction signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration heart development female pregnancy memory positive regulation of norepinephrine secretion response to organic cyclic compound membrane integral component of membrane apical plasma membrane peptide hormone binding telencephalon development sleep positive regulation of synaptic transmission, GABAergic response to estradiol response to progesterone cellular response to hormone stimulus response to anoxia response to cytokine social behavior response to cocaine response to drug maternal behavior sperm ejaculation eating behavior response to peptide hormone regulation of digestive system process estrous cycle positive regulation of blood pressure positive regulation of vasoconstriction response to steroid hormone digestive tract development positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic maternal process involved in parturition positive regulation of penile erection negative regulation of gastric acid secretion ERK1 and ERK2 cascade positive regulation of uterine smooth muscle contraction uc009deb.1 uc009deb.2 uc009deb.3 uc009deb.4 
ENSMUST00000053318.4 Gm5105 ENSMUST00000053318.4 predicted gene 5105 (from RefSeq NR_037975.1) ENSMUST00000053318.1 ENSMUST00000053318.2 ENSMUST00000053318.3 NR_037975 uc008rmv.1 uc008rmv.2 uc008rmv.3 uc008rmv.1 uc008rmv.2 uc008rmv.3 
ENSMUST00000053336.8 2510009E07Rik ENSMUST00000053336.8 RIKEN cDNA 2510009E07 gene (from RefSeq NM_001001881.2) CC070_MOUSE ENSMUST00000053336.1 ENSMUST00000053336.2 ENSMUST00000053336.3 ENSMUST00000053336.4 ENSMUST00000053336.5 ENSMUST00000053336.6 ENSMUST00000053336.7 NM_001001881 Q6GQU0 Q8C8Z2 uc007yrl.1 uc007yrl.2 uc007yrl.3 May play a role in neuronal and neurobehavioral development. Belongs to the UPF0524 family. molecular_function cellular_component biological_process uc007yrl.1 uc007yrl.2 uc007yrl.3 
ENSMUST00000053355.6 Creg2 ENSMUST00000053355.6 cellular repressor of E1A-stimulated genes 2 (from RefSeq NM_170597.4) CREG2_MOUSE ENSMUST00000053355.1 ENSMUST00000053355.2 ENSMUST00000053355.3 ENSMUST00000053355.4 ENSMUST00000053355.5 NM_170597 Q14AL7 Q8BGC9 Q8BL64 Q8BX89 Q8K049 uc007atm.1 uc007atm.2 uc007atm.3 Secreted Brain specific. Belongs to the CREG family. Sequence=BAC32652.1; Type=Erroneous initiation; Evidence=; Sequence=BAC33382.1; Type=Frameshift; Evidence=; molecular_function extracellular region extracellular space endoplasmic reticulum Golgi apparatus biological_process cofactor binding uc007atm.1 uc007atm.2 uc007atm.3 
ENSMUST00000053364.12 Aspm ENSMUST00000053364.12 abnormal spindle microtubule assembly (from RefSeq NM_009791.4) A0A0G2JES1 ASPM_MOUSE B1ARM7 Calmbp1 ENSMUST00000053364.1 ENSMUST00000053364.10 ENSMUST00000053364.11 ENSMUST00000053364.2 ENSMUST00000053364.3 ENSMUST00000053364.4 ENSMUST00000053364.5 ENSMUST00000053364.6 ENSMUST00000053364.7 ENSMUST00000053364.8 ENSMUST00000053364.9 NM_009791 O88482 Q4G1G9 Q8BJI8 Q8BKT4 Q8CJ27 Sha1 uc007cwh.1 uc007cwh.2 uc007cwh.3 Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seem to depend on its association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. Interacts with KATNA1 and KATNB1; katanin complex formation KATNA1:KATNB1 is required for the association. Cytoplasm Cytoplasm, cytoskeleton, spindle Nucleus Note=Localizes to spindle poles during mitosis. Associates with microtubule minus ends (PubMed:28436967). The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CJ27-1; Sequence=Displayed; Name=2; IsoId=Q8CJ27-2; Sequence=VSP_059014; Expressed in fetal brain, peripheral nervous system, liver and spleen. In the adult, expressed exclusively in testis, ovary and spleen. Expressed during cerebral cortical neurogenesis, specifically in the cerebral cortical ventricular zone at 14.5 dpc and 16.5 dpc. Expression is greatly reduced by the day of birth (P0), when neurogenesis in the cortical ventricular zone is completed and gliogenesis is increased. Expression is limited to rare scattered cells in the neocortex by postnatal day 9 (P9). Sequence=AAC79683.1; Type=Erroneous initiation; Evidence=; spindle pole neuron migration positive regulation of neuroblast proliferation calmodulin binding nucleus cytoplasm centrosome spindle cytoskeleton microtubule cell cycle spindle organization spermatogenesis brain development male gonad development apical plasma membrane forebrain neuroblast division cerebral cortex development midbody microtubule minus-end negative regulation of neuron differentiation negative regulation of asymmetric cell division oogenesis developmental growth cell division regulation of meiotic cell cycle spindle localization maintenance of centrosome location meiotic spindle positive regulation of canonical Wnt signaling pathway spindle assembly involved in meiosis neuronal stem cell population maintenance mitotic spindle pole uc007cwh.1 uc007cwh.2 uc007cwh.3 
ENSMUST00000053373.2 P2ry4 ENSMUST00000053373.2 pyrimidinergic receptor P2Y, G-protein coupled, 4 (from RefSeq NM_020621.4) ENSMUST00000053373.1 NM_020621 P2RY4_MOUSE P2y4r Q9JJS7 uc009twc.1 uc009twc.2 Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Cell membrane; Multi-pass membrane protein. Expressed in the liver, intestine, stomach, bladder and lung. Phosphorylation of Ser-329 and Ser-330 is a key step in agonist- dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium-activated kinases (By similarity). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity ATP binding plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane basolateral plasma membrane apical plasma membrane pyrimidine nucleotide binding transepithelial chloride transport G-protein coupled purinergic nucleotide receptor signaling pathway G-protein coupled purinergic nucleotide receptor activity UTP-activated nucleotide receptor activity cellular response to prostaglandin E stimulus glutamatergic synapse integral component of presynaptic active zone membrane regulation of presynaptic cytosolic calcium ion concentration regulation of synaptic vesicle exocytosis uc009twc.1 uc009twc.2 
ENSMUST00000053376.13 Tcte2 ENSMUST00000053376.13 Tcte2 (from geneSymbol) AK005879 ENSMUST00000053376.1 ENSMUST00000053376.10 ENSMUST00000053376.11 ENSMUST00000053376.12 ENSMUST00000053376.2 ENSMUST00000053376.3 ENSMUST00000053376.4 ENSMUST00000053376.5 ENSMUST00000053376.6 ENSMUST00000053376.7 ENSMUST00000053376.8 ENSMUST00000053376.9 uc008amo.1 uc008amo.2 uc008amo.3 uc008amo.4 uc008amo.1 uc008amo.2 uc008amo.3 uc008amo.4 
ENSMUST00000053386.6 Pyurf ENSMUST00000053386.6 Pigy upstream reading frame (from RefSeq NM_025574.3) ENSMUST00000053386.1 ENSMUST00000053386.2 ENSMUST00000053386.3 ENSMUST00000053386.4 ENSMUST00000053386.5 NM_025574 PREY_MOUSE Pigy Prey Q9D1C3 uc009ccm.1 uc009ccm.2 uc009ccm.3 This gene encodes a small protein with a conserved DUF343 domain. The human ortholog of this gene expresses two distinct proteins from upstream and downstream coding regions. The upstream CDS encoding a DUF343 domain-containing protein has been conserved at this mouse locus, but the downstream CDS encoding a subunit of an enzyme involved in glycosylphosphatidylinositol biosynthesis has not been conserved. Instead, a separate locus on mouse chromosome 9 encodes the mouse homolog of the human phosphatidylinositol glycan anchor biosynthesis, class Y protein. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK032381.1, AK011515.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## In mitochondria, S-adenosylmethionine-dependent methyltransferase chaperone that supports both coenzyme Q biosynthesis, by stabilizing its components, such as COQ5, and NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) assembly, by stabilizing complex I assembly factors, such as NDUFAF5. Interacts (via TRM112 domain) with NDUFAF5; the interaction is direct and stabilizes NDUFAF5 protein. Interacts with COQ5; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex. Mitochondrion Belongs to the PREY family. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex molecular_function mitochondrion endoplasmic reticulum membrane cytosol plasma membrane GPI anchor biosynthetic process positive regulation of metabolic process uc009ccm.1 uc009ccm.2 uc009ccm.3 
ENSMUST00000053389.5 Cxcr1 ENSMUST00000053389.5 C-X-C motif chemokine receptor 1 (from RefSeq NM_178241.5) CXCR1_MOUSE ENSMUST00000053389.1 ENSMUST00000053389.2 ENSMUST00000053389.3 ENSMUST00000053389.4 Il8ra NM_178241 Q810W6 uc007blm.1 uc007blm.2 uc007blm.3 Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Interacts with IL8. Interacts with GNAI2. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. interleukin-8 receptor activity G-protein coupled receptor activity plasma membrane chemotaxis immune response signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration external side of plasma membrane membrane integral component of membrane C-C chemokine receptor activity C-X-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding interleukin-8 binding neutrophil chemotaxis receptor internalization interleukin-8-mediated signaling pathway cell chemotaxis chemokine-mediated signaling pathway uc007blm.1 uc007blm.2 uc007blm.3 
ENSMUST00000053392.11 Zfp689 ENSMUST00000053392.11 zinc finger protein 689 (from RefSeq NM_175163.3) ENSMUST00000053392.1 ENSMUST00000053392.10 ENSMUST00000053392.2 ENSMUST00000053392.3 ENSMUST00000053392.4 ENSMUST00000053392.5 ENSMUST00000053392.6 ENSMUST00000053392.7 ENSMUST00000053392.8 ENSMUST00000053392.9 NM_175163 Q8BKK5 Q8C1C6 ZN689_MOUSE Znf689 uc009jvl.1 uc009jvl.2 uc009jvl.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated skeletal muscle cell differentiation metal ion binding uc009jvl.1 uc009jvl.2 uc009jvl.3 
ENSMUST00000053413.12 Cdk5r1 ENSMUST00000053413.12 cyclin dependent kinase 5, regulatory subunit 1 (from RefSeq NM_009871.3) Cdk5a Cdk5r1 ENSMUST00000053413.1 ENSMUST00000053413.10 ENSMUST00000053413.11 ENSMUST00000053413.2 ENSMUST00000053413.3 ENSMUST00000053413.4 ENSMUST00000053413.5 ENSMUST00000053413.6 ENSMUST00000053413.7 ENSMUST00000053413.8 ENSMUST00000053413.9 NM_009871 Q542T9 Q542T9_MOUSE uc011yat.1 uc011yat.2 uc011yat.3 p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. Heterodimer of a catalytic subunit and a regulatory subunit. Cell membrane ; Lipid-anchor ; Cytoplasmic side Cell projection, neuron projection Cytoplasm, perinuclear region Membrane ; Lipid-anchor ; Cytoplasmic side Nucleus Perikaryon Belongs to the cyclin-dependent kinase 5 activator family. calcium ion binding nucleus nucleoplasm cytoplasm G-protein coupled acetylcholine receptor signaling pathway brain development embryo development ending in birth or egg hatching postsynaptic density membrane kinase activity phosphorylation cyclin-dependent protein kinase 5 holoenzyme complex peptidyl-serine phosphorylation peptidyl-threonine phosphorylation protein kinase binding neuron differentiation axon dendrite growth cone neuron projection development neuromuscular junction ionotropic glutamate receptor signaling pathway neuronal cell body dendritic spine intracellular membrane-bounded organelle contractile fiber positive regulation of neuron apoptotic process protein serine/threonine kinase activator activity cadherin binding positive regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated ephrin receptor binding perinuclear region of cytoplasm cyclin-dependent protein serine/threonine kinase activator activity positive regulation of protein serine/threonine kinase activity presynapse uc011yat.1 uc011yat.2 uc011yat.3 
ENSMUST00000053419.9 Lrrc19 ENSMUST00000053419.9 leucine rich repeat containing 19, transcript variant 1 (from RefSeq NM_175305.5) B1AWG3 ENSMUST00000053419.1 ENSMUST00000053419.2 ENSMUST00000053419.3 ENSMUST00000053419.4 ENSMUST00000053419.5 ENSMUST00000053419.6 ENSMUST00000053419.7 ENSMUST00000053419.8 LRC19_MOUSE Lrrc19 NM_175305 Q6P8J1 Q8BZT5 uc008tsh.1 uc008tsh.2 uc008tsh.3 Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of pro-inflammatory cytokines (PubMed:26776522, PubMed:19679103, PubMed:25026888). In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances (PubMed:25026888). In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation (PubMed:26776522). Activated by TLR ligands such as LPS, bacterial DNA and peptidoglycan. Interacts with TRAF2 and TRAF6. Membrane ; Single-pass type I membrane protein Strongly expressed in kidney, also expressed in spleen, intestine and colon (PubMed:26776522, PubMed:19679103). Highly expressed in epithelial cells (PubMed:26776522). In kidney, mainly expressed in renal collecting duct epithelial cells (PubMed:25026888). Knockout mice display increased longevity compared with the cohoused wild-type littermates. Almost all mutant mice remain alive, whereas most of the wild-type mice (>80%) di after 2 years on standard chow. Mutant body weights are lower than those of wild-type. Gut tissues of wild-type mice show slight inflammation whereas mutant mouse gut tissues do not. The gut tissues of mutant mice are more yellow and the colon tissues are thinner in mutant mice than in WT mice and the ceca are enlarged significantly (PubMed:26776522). They show lower expression of cytokines such as TNF, ILB, IL6, IFNG, IL17 and IL12 in the gut tissues (PubMed:26776522). Mice are resistant to dextran sodium sulfate (DSS)-induced colitis and colon cancer (PubMed:26776522). They have fewer and smaller gut tissue-associated lymph node Peyer plaques compared with cohoused wild-type mice with fewer adaptive immune cells that have accumulated in their gut immune systems (PubMed:26776522). Mutants show reduced expression of several chemokines, including CCL6, CCL9, CXCL9, and CXCL10 (PubMed:26776522). They also show an altered gut microbiota and reduced expression of REGs (PubMed:26776522). Mutants are more susceptible to uropathogenic Escherichia coli infections (PubMed:25026888). toll-like receptor signaling pathway plasma membrane membrane integral component of membrane interleukin-8 production signaling receptor activity positive regulation of NIK/NF-kappaB signaling uc008tsh.1 uc008tsh.2 uc008tsh.3 
ENSMUST00000053426.15 Pptc7 ENSMUST00000053426.15 PTC7 protein phosphatase homolog (from RefSeq NM_177242.4) ENSMUST00000053426.1 ENSMUST00000053426.10 ENSMUST00000053426.11 ENSMUST00000053426.12 ENSMUST00000053426.13 ENSMUST00000053426.14 ENSMUST00000053426.2 ENSMUST00000053426.3 ENSMUST00000053426.4 ENSMUST00000053426.5 ENSMUST00000053426.6 ENSMUST00000053426.7 ENSMUST00000053426.8 ENSMUST00000053426.9 NM_177242 PPTC7_MOUSE Q3TS53 Q6NVE9 Q8BVC7 Tapp2c uc008zky.1 uc008zky.2 uc008zky.3 Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q (By similarity). Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (By similarity). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence= Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit. ; Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NVE9-1; Sequence=Displayed; Name=2; IsoId=Q6NVE9-2; Sequence=VSP_032772; Belongs to the PP2C family. catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity mitochondrion mitochondrial matrix regulation of ubiquinone biosynthetic process hydrolase activity metal ion binding peptidyl-serine dephosphorylation uc008zky.1 uc008zky.2 uc008zky.3 
ENSMUST00000053429.11 Zbtb22 ENSMUST00000053429.11 zinc finger and BTB domain containing 22 (from RefSeq NM_020625.3) Bing1 ENSMUST00000053429.1 ENSMUST00000053429.10 ENSMUST00000053429.2 ENSMUST00000053429.3 ENSMUST00000053429.4 ENSMUST00000053429.5 ENSMUST00000053429.6 ENSMUST00000053429.7 ENSMUST00000053429.8 ENSMUST00000053429.9 NM_020625 Q9Z0G7 ZBT22_MOUSE Zfp297 Znf297 uc008cac.1 uc008cac.2 uc008cac.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus biological_process metal ion binding uc008cac.1 uc008cac.2 uc008cac.3 
ENSMUST00000053440.8 Ccdc40 ENSMUST00000053440.8 Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39. (from UniProt Q8BI79) A2AFL0 AK054172 CCD40_MOUSE Ccdc40 ENSMUST00000053440.1 ENSMUST00000053440.2 ENSMUST00000053440.3 ENSMUST00000053440.4 ENSMUST00000053440.5 ENSMUST00000053440.6 ENSMUST00000053440.7 Lnks Q5U4C0 Q8BI59 Q8BI79 uc007mqf.1 uc007mqf.2 uc007mqf.3 Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39. Cytoplasm Cell projection, cilium Note=Localizes to cytoplasm and motile cilium. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BI79-1; Sequence=Displayed; Name=2; IsoId=Q8BI79-2; Sequence=VSP_028310, VSP_028312; Name=3; IsoId=Q8BI79-3; Sequence=VSP_028311, VSP_028313, VSP_028314; Specifically expressed in the embryonic node and midline. Defects are the cause of the lnks phenotype, a phenotype related to primary ciliary dyskinesia (PCD). PCD is characterized by recurrent respiratory infections, situs inversus and ciliary immotility and hydrocephalus. The length of the cilia projecting from the nodal pit cells in mutants is drastically reduced. Belongs to the CCDC40 family. Sequence=AAH85159.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; heart looping cilium movement epithelial cilium movement regulation of cilium beat frequency molecular_function extracellular region cytoplasm cilium axoneme flagellated sperm motility lung development motile cilium axoneme assembly determination of pancreatic left/right asymmetry inner dynein arm assembly cell projection motile cilium assembly cilium assembly epithelial cilium movement involved in determination of left/right asymmetry protein localization to cilium axonemal dynein complex assembly determination of digestive tract left/right asymmetry determination of liver left/right asymmetry uc007mqf.1 uc007mqf.2 uc007mqf.3 
ENSMUST00000053441.5 Adam29 ENSMUST00000053441.5 a disintegrin and metallopeptidase domain 29 (from RefSeq NM_175939.3) Adam29 ENSMUST00000053441.1 ENSMUST00000053441.2 ENSMUST00000053441.3 ENSMUST00000053441.4 G3X9B5 G3X9B5_MOUSE NM_175939 uc009lsm.1 uc009lsm.2 uc009lsm.3 uc009lsm.4 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. [provided by RefSeq, May 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AY190759.1, BC119089.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. metalloendopeptidase activity proteolysis metallopeptidase activity membrane integral component of membrane uc009lsm.1 uc009lsm.2 uc009lsm.3 uc009lsm.4 
ENSMUST00000053445.18 Kndc1 ENSMUST00000053445.18 kinase non-catalytic C-lobe domain (KIND) containing 1 (from RefSeq NM_177261.4) ENSMUST00000053445.1 ENSMUST00000053445.10 ENSMUST00000053445.11 ENSMUST00000053445.12 ENSMUST00000053445.13 ENSMUST00000053445.14 ENSMUST00000053445.15 ENSMUST00000053445.16 ENSMUST00000053445.17 ENSMUST00000053445.2 ENSMUST00000053445.3 ENSMUST00000053445.4 ENSMUST00000053445.5 ENSMUST00000053445.6 ENSMUST00000053445.7 ENSMUST00000053445.8 ENSMUST00000053445.9 KNDC1_MOUSE Kiaa1768 Kndc1 NM_177261 Q0KK50 Q0KK55 Q3TF27 Q3UGX9 Q3UGZ3 Q3UHK4 Q7TNH0 Q8BTH5 Q8BXJ3 Rasgef2 Vkind uc009kgd.1 uc009kgd.2 uc009kgd.3 RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (PubMed:17984326, PubMed:21385318). May be involved in cellular senescence (By similarity). Interacts (via KIND2) with MAP2; the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites. Q0KK55; P20357: Map2; NbExp=9; IntAct=EBI-8605532, EBI-397863; Cell projection, dendrite Perikaryon Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q0KK55-1; Sequence=Displayed; Name=2; IsoId=Q0KK55-2; Sequence=VSP_028600, VSP_028601; Name=3; IsoId=Q0KK55-3; Sequence=VSP_028599; Highly expressed in the brain and at low levels in the ovary. In the brain it is most prominently expressed in the cerebellum where it is restricted to the granular Purkinje cell layer. At 14.5 dpc, highly expressed in the mid- and hindbrain and only weakly in the forebrain, but during development the main expression shifts towards the telencephalon as seen at 17.5 dpc (PubMed:16099729). In cerebellum expression is highly up-regulated between postnatal days P7 and P12. At P7, low expression levels throughout the brain, but high in hippocampus, thalamus and the cerebellar white matter (PubMed:17984326). Sequence=BAC41157.1; Type=Frameshift; Evidence=; positive regulation of protein phosphorylation guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity protein binding small GTPase mediated signal transduction cerebellar granule cell differentiation dendrite guanyl-nucleotide exchange factor complex cell projection neuronal cell body perikaryon regulation of dendrite morphogenesis regulation of dendrite development uc009kgd.1 uc009kgd.2 uc009kgd.3 
ENSMUST00000053458.7 Fam228b ENSMUST00000053458.7 family with sequence similarity 228, member B, transcript variant 3 (from RefSeq NM_175431.5) ENSMUST00000053458.1 ENSMUST00000053458.2 ENSMUST00000053458.3 ENSMUST00000053458.4 ENSMUST00000053458.5 ENSMUST00000053458.6 F228B_MOUSE NM_175431 Q497Q6 Q8BLM3 Q8BWN5 uc007mye.1 uc007mye.2 uc007mye.3 uc007mye.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q497Q6-1; Sequence=Displayed; Name=2; IsoId=Q497Q6-2; Sequence=VSP_035165, VSP_035166; Belongs to the FAM228 family. Sequence=BAC34259.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc007mye.1 uc007mye.2 uc007mye.3 uc007mye.4 
ENSMUST00000053459.15 Pxdc1 ENSMUST00000053459.15 PX domain containing 1, transcript variant 2 (from RefSeq NM_025831.3) A0PJ93 ENSMUST00000053459.1 ENSMUST00000053459.10 ENSMUST00000053459.11 ENSMUST00000053459.12 ENSMUST00000053459.13 ENSMUST00000053459.14 ENSMUST00000053459.2 ENSMUST00000053459.3 ENSMUST00000053459.4 ENSMUST00000053459.5 ENSMUST00000053459.6 ENSMUST00000053459.7 ENSMUST00000053459.8 ENSMUST00000053459.9 NM_025831 PXDC1_MOUSE Q8JZU6 Q9DBE6 uc007qbi.1 uc007qbi.2 uc007qbi.3 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8JZU6-1; Sequence=Displayed; Name=2; IsoId=Q8JZU6-2; Sequence=VSP_027286; Name=3; IsoId=Q8JZU6-3; Sequence=VSP_027284, VSP_027285; molecular_function cellular_component biological_process phosphatidylinositol binding uc007qbi.1 uc007qbi.2 uc007qbi.3 
ENSMUST00000053460.4 Krtap19-5 ENSMUST00000053460.4 keratin associated protein 19-5 (from RefSeq NM_010676.2) ENSMUST00000053460.1 ENSMUST00000053460.2 ENSMUST00000053460.3 F8VQ65 F8VQ65_MOUSE Krtap19-5 Krtap8-2 NM_010676 uc007zvl.1 uc007zvl.2 uc007zvl.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the KRTAP type 19 family. uc007zvl.1 uc007zvl.2 uc007zvl.3 
ENSMUST00000053467.6 Zfpm2 ENSMUST00000053467.6 zinc finger protein, multitype 2, transcript variant 1 (from RefSeq NM_011766.5) ENSMUST00000053467.1 ENSMUST00000053467.2 ENSMUST00000053467.3 ENSMUST00000053467.4 ENSMUST00000053467.5 FOG2_MOUSE Fog2 NM_011766 Q8CCH7 Q9Z0F2 uc007vos.1 uc007vos.2 uc007vos.3 Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2. Interacts with the N-terminal zinc-finger of GATA4, GATA5 and probably GATA6. Interacts with retinoid nuclear receptor RXRA when ligand bound. Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity. Interacts with NR2F2 and NR2F6. Interacts with ATOH8; mediates indirect interaction with GATA4. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CCH7-1; Sequence=Displayed; Name=2; IsoId=Q8CCH7-2; Sequence=VSP_009703, VSP_009704; Name=3; IsoId=Q8CCH7-3; Sequence=VSP_009705; Expressed in heart, brain and testis. Weakly expressed in lung and liver. First expressed at approximately E8.5 in the developing ventral heart tube and septum transversum. Cardiac expression persists throughout the remainder of embryonic development in the atria as well as in all layers of the ventricles (endocardium, myocardium, and pericardium). Expressed in the neuroepithelium of the developing midbrain and hindbrain from 11.5 dpc and increased in intensity between 12 dpc and 16.5 dpc. Also expressed in the urogenital ridge beginning at 11.5 dpc and subsequently localized to the gonads by 16.5 dpc. Colocalizes with GATA4 GATA5 and GATA6 in the developing heart, GATA3 in the brain, and GATA4 in the gonads. The CCHC FOG-type zinc fingers 1, 2, 3 and 5 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is probably essential for the interaction with GATA-type zinc fingers. Sumoylation reduces transcriptional repression activity. Mice die of congestive heart failure at 13 dpc with a syndrome of tricuspid atresia that includes an absent tricuspid valve, a large atrial and ventricular spetal defects, an elongated left ventricular outflow tract, rightward displacement of the aortic valve and pulmonic stenosis. These mice also display hypoplasia of the compact zone of the left ventricle. [Isoform 3]: Splicing donor site between exon 3 and 4 is not canonical. Belongs to the FOG (Friend of GATA) family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding vasculogenesis in utero embryonic development outflow tract septum morphogenesis outflow tract morphogenesis atrioventricular valve morphogenesis mitral valve formation tricuspid valve formation right ventricular cardiac muscle tissue morphogenesis nucleic acid binding DNA binding transcription corepressor activity protein binding nucleus nucleoplasm cytoplasm regulation of transcription from RNA polymerase II promoter heart development transcription factor binding lung development negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding embryonic organ development cardiac muscle tissue development cardiac muscle tissue morphogenesis positive regulation of cardiac muscle cell proliferation ventricular septum morphogenesis negative regulation of cell death vasculogenesis involved in coronary vascular morphogenesis negative regulation of nucleic acid-templated transcription positive regulation of male gonad development negative regulation of female gonad development uc007vos.1 uc007vos.2 uc007vos.3 
ENSMUST00000053484.8 Eea1 ENSMUST00000053484.8 early endosome antigen 1 (from RefSeq NM_001001932.3) EEA1_MOUSE ENSMUST00000053484.1 ENSMUST00000053484.2 ENSMUST00000053484.3 ENSMUST00000053484.4 ENSMUST00000053484.5 ENSMUST00000053484.6 ENSMUST00000053484.7 NM_001001932 Q6DIC2 Q8BL66 uc007gwv.1 uc007gwv.2 uc007gwv.3 Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with ERBB2 (By similarity). Interacts with RAB31. Interacts with SAMD9 and SAMD9L (By similarity). May interact with PLEKHF2 (By similarity). Cytoplasm Early endosome membrane ; Peripheral membrane protein The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions (By similarity). Sequence=BAC32647.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; nucleic acid binding protein binding 1-phosphatidylinositol binding cytoplasm endosome early endosome cytosol serine-pyruvate aminotransferase complex endocytosis vesicle fusion membrane extrinsic component of plasma membrane GTP-dependent protein binding cytoplasmic vesicle early endosome membrane viral RNA genome replication protein homodimerization activity axonal spine metal ion binding recycling endosome uc007gwv.1 uc007gwv.2 uc007gwv.3 
ENSMUST00000053491.9 Pou3f1 ENSMUST00000053491.9 POU domain, class 3, transcription factor 1 (from RefSeq NM_011141.2) ENSMUST00000053491.1 ENSMUST00000053491.2 ENSMUST00000053491.3 ENSMUST00000053491.4 ENSMUST00000053491.5 ENSMUST00000053491.6 ENSMUST00000053491.7 ENSMUST00000053491.8 NM_011141 Oct6 Otf-6 Otf6 P21952 PO3F1_MOUSE Scip uc029uzh.1 uc029uzh.2 uc029uzh.3 Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') (PubMed:1979677, PubMed:1976514). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (PubMed:18505825). Acts as a transcriptional repressor of myelin-specific genes (By similarity). Nucleus Expressed in embryonal stem cells and in the developing brain (PubMed:1979677). Down-regulated in embryonic stem cells upon differentiation (PubMed:1979677). Expressed in the sciatic nerves at postnatal days P6 to P12 (PubMed:10068633). Belongs to the POU transcription factor family. Class-3 subfamily. RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter brain development epidermis development positive regulation of gene expression Schwann cell development myelination in peripheral nervous system keratinocyte differentiation forebrain development myelination sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc029uzh.1 uc029uzh.2 uc029uzh.3 
ENSMUST00000053506.8 Bbs1 ENSMUST00000053506.8 Bardet-Biedl syndrome 1 (from RefSeq NM_001033128.3) BBS1_MOUSE ENSMUST00000053506.1 ENSMUST00000053506.2 ENSMUST00000053506.3 ENSMUST00000053506.4 ENSMUST00000053506.5 ENSMUST00000053506.6 ENSMUST00000053506.7 NM_001033128 Q3V3N7 uc008gbk.1 uc008gbk.2 uc008gbk.3 uc008gbk.4 uc008gbk.5 The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly (By similarity). Plays a role in olfactory cilium biogenesis/maintenance and trafficking and is essential for the localization of the BBSome complex in the olfactory sensory neurons cilia (PubMed:15322545, PubMed:28237838). Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts with the C-terminus of RAB3IP. Interacts with CCDC28B and ALDOB. Interacts with PKD1. Q3V3N7; Q8C1Z7: Bbs4; NbExp=5; IntAct=EBI-2892836, EBI-2892887; Cell projection, cilium membrane Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Mice are anosmic (inability to perceive odors) and have defective olfactory cilia. Significant reduction in olfactory sensory neurons ciliation in the olfactory epithelium with decreased cilium length and number. Impaired cilium localization of the BBSome complex. microtubule cytoskeleton organization RNA polymerase II repressing transcription factor binding neuron migration retina homeostasis receptor binding patched binding smoothened binding protein binding cytoplasm centrosome microtubule organizing center cytoskeleton plasma membrane cilium axoneme visual perception sensory perception of smell protein localization photoreceptor cell morphogenesis fertilization protein transport membrane dendrite development ventricular system development striatum development hippocampus development cerebral cortex development cell projection organization adult behavior motile cilium centriolar satellite BBSome intraciliary retrograde transport ciliary basal body olfactory behavior hormone metabolic process cell projection Golgi to plasma membrane protein transport cellular lipid metabolic process fat cell differentiation photoreceptor cell maintenance brain morphogenesis response to stimulus cartilage development phosphoprotein binding ciliary membrane cilium assembly regulation of cilium beat frequency involved in ciliary motility neural precursor cell proliferation protein localization to cilium non-motile cilium assembly uc008gbk.1 uc008gbk.2 uc008gbk.3 uc008gbk.4 uc008gbk.5 
ENSMUST00000053536.5 Cdc42ep4 ENSMUST00000053536.5 CDC42 effector protein 4, transcript variant 2 (from RefSeq NM_001163346.1) BORG4_MOUSE Borg4 Cep4 ENSMUST00000053536.1 ENSMUST00000053536.2 ENSMUST00000053536.3 ENSMUST00000053536.4 NM_001163346 Q3TNF3 Q9JM96 Q9QZT8 uc007mfc.1 uc007mfc.2 uc007mfc.3 uc007mfc.4 Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. Interacts with CDC42 and RHOQ, in a GTP-dependent manner. Endomembrane system ; Peripheral membrane protein Cytoplasm, cytoskeleton Ubiquitous. Belongs to the BORG/CEP family. protein binding cytoplasm cytoskeleton plasma membrane cell-cell adherens junction Rho protein signal transduction regulation of cell shape endomembrane system actin cytoskeleton microtubule cytoskeleton membrane GTP-Rho binding positive regulation of actin filament polymerization positive regulation of pseudopodium assembly phagocytic vesicle cellular response to interferon-gamma uc007mfc.1 uc007mfc.2 uc007mfc.3 uc007mfc.4 
ENSMUST00000053543.11 Tecrl ENSMUST00000053543.11 trans-2,3-enoyl-CoA reductase-like (from RefSeq NM_153801.3) ENSMUST00000053543.1 ENSMUST00000053543.10 ENSMUST00000053543.2 ENSMUST00000053543.3 ENSMUST00000053543.4 ENSMUST00000053543.5 ENSMUST00000053543.6 ENSMUST00000053543.7 ENSMUST00000053543.8 ENSMUST00000053543.9 NM_153801 Q8BFZ1 Q8CIX3 Srd5a2l2 TECRL_MOUSE uc008xwu.1 uc008xwu.2 uc008xwu.3 uc008xwu.4 Membrane ; Multi-pass membrane protein Endoplasmic reticulum Expression is highest in the heart with very low to almost undetectable levels in brain, skeletal muscle, stomach, pancreas, liver, kidney, small intestine, and uterus. At embryonic day 8.5 dpc, expressed in the developing heart with the strongest expression occurring in the inflow tract, especially in the left horn. At 9.5 dpc, expression is still detectable in the atria and ventricles, albeit at lower levels whereas strong expression remains in the inflow tract. From 10 dpc onwards, it is also expressed at low levels in somites, particularly in the myotome region, that gives rise to skeletal muscle. At 10.5 dpc, cardiac expression is no longer restricted to the inflow tract. At 14.5 dpc, it is expressed in the entire myocardium. Belongs to the steroid 5-alpha reductase family. endoplasmic reticulum lipid metabolic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors very long-chain fatty acid biosynthetic process oxidation-reduction process uc008xwu.1 uc008xwu.2 uc008xwu.3 uc008xwu.4 
ENSMUST00000053558.10 Ankrd37 ENSMUST00000053558.10 ankyrin repeat domain 37, transcript variant 3 (from RefSeq NM_001404727.1) ANR37_MOUSE Ankrd37 ENSMUST00000053558.1 ENSMUST00000053558.2 ENSMUST00000053558.3 ENSMUST00000053558.4 ENSMUST00000053558.5 ENSMUST00000053558.6 ENSMUST00000053558.7 ENSMUST00000053558.8 ENSMUST00000053558.9 NM_001404727 Q569N2 Q8CHS0 uc009lpr.1 uc009lpr.2 uc009lpr.3 Nucleus Cytoplasm Note=Present in the cytoplasm of elongating spermatids of the stages IX-X seminiferous tubules while it is localizes to the nucleus of spermatozoa of the stages VII-VIII tubules and mature spermatozoa isolated from epididymis. Expressed testis, ovary, uterus, kidney, liver, but not in other tissues. Ubiquitinated by the CRL2(FEM1B) complex, leading to its degradation. protein binding nucleus cytoplasm mitochondrion cytosol biological_process uc009lpr.1 uc009lpr.2 uc009lpr.3 
ENSMUST00000053577.9 Epcam ENSMUST00000053577.9 epithelial cell adhesion molecule (from RefSeq NM_008532.2) ENSMUST00000053577.1 ENSMUST00000053577.2 ENSMUST00000053577.3 ENSMUST00000053577.4 ENSMUST00000053577.5 ENSMUST00000053577.6 ENSMUST00000053577.7 ENSMUST00000053577.8 EPCAM_MOUSE NM_008532 Q61512 Q99JW5 Tacstd1 uc008duy.1 uc008duy.2 uc008duy.3 May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). Monomer. Interacts with phosphorylated CLDN7 (By similarity). Lateral cell membrane ; Single-pass type I membrane protein Cell junction, tight junction Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. Glycosylation at Asn-198 is crucial for protein stability. Belongs to the EPCAM family. ureteric bud development plasma membrane bicellular tight junction positive regulation of cell proliferation cell surface membrane integral component of membrane basolateral plasma membrane apical plasma membrane lateral plasma membrane signal transduction involved in regulation of gene expression cell junction negative regulation of apoptotic process macromolecular complex binding positive regulation of transcription from RNA polymerase II promoter stem cell differentiation cadherin binding involved in cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules negative regulation of cell-cell adhesion mediated by cadherin positive regulation of cell motility positive regulation of stem cell proliferation uc008duy.1 uc008duy.2 uc008duy.3 
ENSMUST00000053583.7 Swsap1 ENSMUST00000053583.7 SWIM type zinc finger 7 associated protein 1 (from RefSeq NM_025870.1) A7E2S1 ENSMUST00000053583.1 ENSMUST00000053583.2 ENSMUST00000053583.3 ENSMUST00000053583.4 ENSMUST00000053583.5 ENSMUST00000053583.6 NM_025870 Q8BRM3 Q8VCI7 Q9CV33 SWAP1_MOUSE uc009onc.1 uc009onc.2 uc009onc.3 uc009onc.4 ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity (By similarity). Interacts with ZSWIM7; they form a functional complex involved in homologous recombination repair and stabilize each other. Interacts with RAD51, RAD51B, RAD51C, RAD51D and XRCC3; involved in homologous recombination repair (By similarity). Nucleus Sequence=BAB26550.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; double-strand break repair via homologous recombination DNA binding single-stranded DNA binding nucleus DNA repair DNA recombination cellular response to DNA damage stimulus ATPase activity protein stabilization Shu complex uc009onc.1 uc009onc.2 uc009onc.3 uc009onc.4 
ENSMUST00000053593.8 Rap2c ENSMUST00000053593.8 RAP2C, member of RAS oncogene family, transcript variant 1 (from RefSeq NM_172413.3) ENSMUST00000053593.1 ENSMUST00000053593.2 ENSMUST00000053593.3 ENSMUST00000053593.4 ENSMUST00000053593.5 ENSMUST00000053593.6 ENSMUST00000053593.7 NM_172413 Q504Q0 Q6P1Y7 Q810J4 Q8BU31 Q8R2P4 RAP2C_MOUSE uc009tds.1 uc009tds.2 uc009tds.3 Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Cytoplasm Recycling endosome membrane ; Lipid-anchor ; Cytoplasmic side Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK. Belongs to the small GTPase superfamily. Ras family. nucleotide binding transcription coactivator activity GTPase activity GTP binding cytoplasm endosome cytosol plasma membrane bicellular tight junction signal transduction membrane GDP binding negative regulation of cell migration positive regulation of protein autophosphorylation Rap protein signal transduction cell-cell contact zone recycling endosome recycling endosome membrane regulation of protein tyrosine kinase activity establishment of endothelial intestinal barrier positive regulation of nucleic acid-templated transcription uc009tds.1 uc009tds.2 uc009tds.3 
ENSMUST00000053594.7 Cradd ENSMUST00000053594.7 CASP2 and RIPK1 domain containing adaptor with death domain, transcript variant 2 (from RefSeq NM_009950.3) Cradd ENSMUST00000053594.1 ENSMUST00000053594.2 ENSMUST00000053594.3 ENSMUST00000053594.4 ENSMUST00000053594.5 ENSMUST00000053594.6 NM_009950 Q549T4 Q549T4_MOUSE uc007gwc.1 uc007gwc.2 uc007gwc.3 protease binding DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest signal transduction protein binding, bridging regulation of apoptotic process positive regulation of apoptotic process death domain binding cellular response to mechanical stimulus apoptotic signaling pathway uc007gwc.1 uc007gwc.2 uc007gwc.3 
ENSMUST00000053611.5 Cox8c ENSMUST00000053611.5 cytochrome c oxidase subunit 8C (from RefSeq NM_001039049.1) A6H666 COX8C_MOUSE ENSMUST00000053611.1 ENSMUST00000053611.2 ENSMUST00000053611.3 ENSMUST00000053611.4 NM_001039049 uc007ouv.1 uc007ouv.2 uc007ouv.3 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Energy metabolism; oxidative phosphorylation. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the cytochrome c oxidase VIII family. cytochrome-c oxidase activity mitochondrion mitochondrial inner membrane membrane integral component of membrane electron transport chain respiratory chain complex IV hydrogen ion transmembrane transport uc007ouv.1 uc007ouv.2 uc007ouv.3 
ENSMUST00000053635.5 ENSMUSG00000121857 ENSMUST00000053635.5 ENSMUSG00000121857 (from geneSymbol) AK029660 ENSMUST00000053635.1 ENSMUST00000053635.2 ENSMUST00000053635.3 ENSMUST00000053635.4 uc291nrc.1 uc291nrc.2 uc291nrc.1 uc291nrc.2 
ENSMUST00000053640.5 Adrb2 ENSMUST00000053640.5 adrenergic receptor, beta 2 (from RefSeq NM_007420.3) ADRB2_MOUSE Adrb2r ENSMUST00000053640.1 ENSMUST00000053640.2 ENSMUST00000053640.3 ENSMUST00000053640.4 NM_007420 P18762 Q8BH38 uc008fcy.1 uc008fcy.2 uc008fcy.3 uc008fcy.4 uc008fcy.5 This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 adrenergic receptor which is activated by catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript regulatory uORF :: PMID: 8308019 ##RefSeq-Attributes-END## Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Binds NHERF1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC (By similarity). Interacts with USP20 and USP33 (By similarity). Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4. Interacts with ARRDC3. Interacts with NEDD4 (By similarity). Interacts with MARCHF2 (By similarity). P18762; P34971: Adrb1; NbExp=2; IntAct=EBI-491143, EBI-7764182; P18762; P51637: Cav3; NbExp=2; IntAct=EBI-491143, EBI-298576; P18762; P70424: Erbb2; NbExp=3; IntAct=EBI-491143, EBI-2945468; Cell membrane ; Multi-pass membrane protein Early endosome Golgi apparatus Note=Colocalizes with VHL at the cell membrane. Activated receptors are internalized into endosomes prior to their degradation in lysosomes. Activated receptors are also detected within the Golgi apparatus. Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity). Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK. Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor. Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent (By similarity). Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2. Palmitoylated. Mainly palmitoylated at Cys-341. Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi. Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor. Could be depalmitoylated by LYPLA1 at the plasma membrane. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. beta-amyloid binding G-protein alpha-subunit binding regulation of systemic arterial blood pressure by norepinephrine-epinephrine diet induced thermogenesis vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure regulation of sodium ion transport desensitization of G-protein coupled receptor protein signaling pathway by arrestin diaphragm contraction positive regulation of the force of heart contraction by epinephrine G-protein coupled receptor activity adrenergic receptor activity beta2-adrenergic receptor activity protein binding nucleus cytoplasm endosome early endosome plasma membrane integral component of plasma membrane caveola receptor-mediated endocytosis regulation of smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity drug binding adenylate cyclase binding positive regulation of cell proliferation associative learning response to cold positive regulation of protein kinase A signaling positive regulation of sodium ion transport potassium channel regulator activity membrane integral component of membrane apical plasma membrane negative regulation of angiogenesis enzyme binding negative regulation of ossification axon dendrite positive regulation of bone mineralization positive regulation of protein ubiquitination heat generation B2 bradykinin receptor binding positive regulation of ATPase activity neuronal cell body membrane dopamine binding synaptic transmission, glutamatergic ionotropic glutamate receptor binding negative regulation of urine volume negative regulation of multicellular organism growth wound healing sarcolemma protein homodimerization activity positive regulation of apoptotic process dendritic spine intracellular membrane-bounded organelle receptor complex positive regulation of potassium ion transport positive regulation of MAPK cascade macromolecular complex binding bone resorption positive regulation of heart contraction positive regulation of transcription from RNA polymerase II promoter negative regulation of smooth muscle contraction positive regulation of skeletal muscle tissue growth negative regulation of inflammatory response brown fat cell differentiation epinephrine binding norepinephrine binding protein phosphatase 2A binding regulation of calcium ion transport regulation of sensory perception of pain excitatory postsynaptic potential cellular response to hypoxia adrenergic receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway positive regulation of protein serine/threonine kinase activity negative regulation of platelet aggregation receptor-receptor interaction regulation of blood vessel diameter glutamatergic synapse positive regulation of autophagosome maturation positive regulation of lipophagy cellular response to beta-amyloid positive regulation of calcium ion import across plasma membrane regulation of synaptic vesicle exocytosis positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc008fcy.1 uc008fcy.2 uc008fcy.3 uc008fcy.4 uc008fcy.5 
ENSMUST00000053646.7 S1pr4 ENSMUST00000053646.7 sphingosine-1-phosphate receptor 4 (from RefSeq NM_010102.2) ENSMUST00000053646.1 ENSMUST00000053646.2 ENSMUST00000053646.3 ENSMUST00000053646.4 ENSMUST00000053646.5 ENSMUST00000053646.6 Edg6 Lpc1 NM_010102 Q3U4H3 Q8C6E2 Q8K1R9 Q9Z0L1 S1PR4_MOUSE S1p4 uc007gih.1 uc007gih.2 uc007gih.3 uc007gih.4 This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The encoded protein is one of the predominant sphingosine 1-phosphate G-protein coupled receptors expressed in T cells, and it plays a role in suppression of T cell proliferation, generation of cytokines, and potentially other aspects of immune activation. [provided by RefSeq, Feb 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes (By similarity). Cell membrane; Multi-pass membrane protein. Specifically expressed in fetal and adult lymphoid and hematopoietic tissue. Expressed in lung, spleen, thymus and lymph node but absent in other non-lymphatic tissue. Coexpressed with GNA15 at the same relative levels in all tissues examined, with the highest levels in adult spleen and lung. Belongs to the G-protein coupled receptor 1 family. sphingosine-1-phosphate signaling pathway G-protein coupled receptor activity mitochondrion plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway membrane integral component of membrane sphingosine-1-phosphate receptor activity uc007gih.1 uc007gih.2 uc007gih.3 uc007gih.4 
ENSMUST00000053652.6 Tas2r105 ENSMUST00000053652.6 taste receptor, type 2, member 105 (from RefSeq NM_020501.1) ENSMUST00000053652.1 ENSMUST00000053652.2 ENSMUST00000053652.3 ENSMUST00000053652.4 ENSMUST00000053652.5 NM_020501 Q9JKT4 TR105_MOUSE Tas2r5 Tas2r9 uc009eiz.1 uc009eiz.2 uc009eiz.3 Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Membrane; Multi-pass membrane protein. Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in gastric and duodenal tissues. Variations in Tas2r105 are associated with avoidance of cycloheximide at low concentrations. Mice fail to avoid cycloheximide at low concentrations and show a lack of cycloheximide-induced action potentials in a principal nerve innervating taste receptor cells of the tongue. Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway taste receptor activity membrane integral component of membrane response to stimulus sensory perception of taste sensory perception of bitter taste uc009eiz.1 uc009eiz.2 uc009eiz.3 
ENSMUST00000053659.2 Gpr82 ENSMUST00000053659.2 G protein-coupled receptor 82 (from RefSeq NM_175669.4) ENSMUST00000053659.1 GPR82_MOUSE NM_175669 Q80UB1 Q8BZR0 uc009srv.1 uc009srv.2 Orphan receptor. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane uc009srv.1 uc009srv.2 
ENSMUST00000053661.7 Gimap6 ENSMUST00000053661.7 GTPase, IMAP family member 6 (from RefSeq NM_153175.3) ENSMUST00000053661.1 ENSMUST00000053661.2 ENSMUST00000053661.3 ENSMUST00000053661.4 ENSMUST00000053661.5 ENSMUST00000053661.6 GIMA6_MOUSE Ian6 NM_153175 Q5DU66 Q8K349 Q8K434 uc009bvm.1 uc009bvm.2 uc009bvm.3 This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AK050328.1, BC028779.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cytoplasm, cytosol Expressed in thymus (in thymocytes), spleen (in splenocytes), lymph node and lung. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. Sequence=BAD90383.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence=; nucleotide binding GTP binding nucleoplasm cytoplasm endoplasmic reticulum cytosol biological_process uc009bvm.1 uc009bvm.2 uc009bvm.3 
ENSMUST00000053663.11 Wdr36 ENSMUST00000053663.11 WD repeat domain 36, transcript variant 3 (from RefSeq NM_144863.5) ENSMUST00000053663.1 ENSMUST00000053663.10 ENSMUST00000053663.2 ENSMUST00000053663.3 ENSMUST00000053663.4 ENSMUST00000053663.5 ENSMUST00000053663.6 ENSMUST00000053663.7 ENSMUST00000053663.8 ENSMUST00000053663.9 NM_144863 Q3TAQ9 Q3TAQ9_MOUSE Wdr36 uc008ejn.1 uc008ejn.2 uc008ejn.3 uc008ejn.4 retina homeostasis nucleolus rRNA processing regulation of axon extension small-subunit processome Pwp2p-containing subcomplex of 90S preribosome uc008ejn.1 uc008ejn.2 uc008ejn.3 uc008ejn.4 
ENSMUST00000053670.12 Cracr2b ENSMUST00000053670.12 calcium release activated channel regulator 2B (from RefSeq NM_001025103.2) EFC4A_MOUSE ENSMUST00000053670.1 ENSMUST00000053670.10 ENSMUST00000053670.11 ENSMUST00000053670.2 ENSMUST00000053670.3 ENSMUST00000053670.4 ENSMUST00000053670.5 ENSMUST00000053670.6 ENSMUST00000053670.7 ENSMUST00000053670.8 ENSMUST00000053670.9 Efcab4a NM_001025103 Q4KMV3 Q80ZJ8 Q8R0L0 uc009klj.1 uc009klj.2 uc009klj.3 uc009klj.4 Plays a role in store-operated Ca(2+) entry (SOCE). Belongs to the EFCAB4 family. Sequence=AAH48916.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; store-operated calcium entry calcium ion binding protein binding cytoplasm cellular protein localization regulation of store-operated calcium entry uc009klj.1 uc009klj.2 uc009klj.3 uc009klj.4 
ENSMUST00000053681.6 Frrs1l ENSMUST00000053681.6 ferric-chelate reductase 1 like (from RefSeq NM_001142965.2) A3KMM1 B1AXV0 ENSMUST00000053681.1 ENSMUST00000053681.2 ENSMUST00000053681.3 ENSMUST00000053681.4 ENSMUST00000053681.5 FRS1L_MOUSE NM_001142965 Q8BYS5 uc008sxx.1 uc008sxx.2 uc008sxx.3 uc008sxx.4 Important modulator of glutamate signaling pathway. Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Cell membrane Synapse Expressed in the brain (at protein level) (PubMed:22632720). In embryos expression is evident in the ventral forebrain, but a lower level is seen in the remainder of the embryos. In the adult brain, expressed in the cortex, cerebellum, hippocampus and basal ganglia (PubMed:27236917). Expressed in 12.5 dpc embryos. Sequence=AAI32346.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component plasma membrane membrane integral component of membrane cell junction synapse regulation of postsynaptic specialization membrane neurotransmitter receptor levels regulation of glutamate receptor signaling pathway uc008sxx.1 uc008sxx.2 uc008sxx.3 uc008sxx.4 
ENSMUST00000053683.7 Ggnbp1 ENSMUST00000053683.7 gametogenetin binding protein 1, transcript variant 1 (from RefSeq NM_027544.2) B9WZ58 ENSMUST00000053683.1 ENSMUST00000053683.2 ENSMUST00000053683.3 ENSMUST00000053683.4 ENSMUST00000053683.5 ENSMUST00000053683.6 GGNB1_MOUSE NM_027544 Q6K1E7 Q8C5T9 uc289iro.1 uc289iro.2 Induces mitochondrial fragmentation, possibly by promoting DNM1L-dependent fission and may play a role in mitochondrial morphogenesis during spermatogenesis. Interacts with isoform 1 and isoform 2 of GGN. Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus. Mitochondrion intermembrane space. Testis-specific. In the testis, expressed only in germ cells and not in somatic cells. Expression starts in late primary spermatocytes in stage X-XII tubules and gradually increases towards step 1-3 spermatids in stage I-III tubules. Expression then declines continuously and disappears after step 7 spermatids in stage VII tubules (at protein level). Specifically expressed in germ cells tightly related to meiosis. In the developing mouse testis, it is not detected in the testes of 14-day-old mice, when pachytene spermatocytes are still in their early stage, while it is detected in tubules with late pachytene spermatocytes and spermatids in the testes of 21-day-old mice. The N-terminal domain is required for targeting to the mitochondrion. mitochondrial fission protein binding cytoplasm mitochondrion mitochondrial intermembrane space Golgi apparatus plasma membrane multicellular organism development spermatogenesis membrane cell differentiation uc289iro.1 uc289iro.2 
ENSMUST00000053686.9 Uck2 ENSMUST00000053686.9 uridine-cytidine kinase 2, transcript variant 1 (from RefSeq NM_030724.4) ENSMUST00000053686.1 ENSMUST00000053686.2 ENSMUST00000053686.3 ENSMUST00000053686.4 ENSMUST00000053686.5 ENSMUST00000053686.6 ENSMUST00000053686.7 ENSMUST00000053686.8 NM_030724 Q99PM9 UCK2_MOUSE Umpk uc007dku.1 uc007dku.2 uc007dku.3 uc007dku.4 uc007dku.5 Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Reaction=ATP + uridine = ADP + H(+) + UMP; Xref=Rhea:RHEA:16825, ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:30616, ChEBI:CHEBI:57865, ChEBI:CHEBI:456216; EC=2.7.1.48; Evidence=; Reaction=ATP + cytidine = ADP + CMP + H(+); Xref=Rhea:RHEA:24674, ChEBI:CHEBI:15378, ChEBI:CHEBI:17562, ChEBI:CHEBI:30616, ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.1.48; Evidence=; Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. Homotetramer. Q99PM9; Q60631: Grb2; NbExp=3; IntAct=EBI-644712, EBI-1688; Belongs to the uridine kinase family. nucleotide binding uridine kinase activity protein binding ATP binding cytosol kinase activity phosphorylation transferase activity nucleoside kinase activity identical protein binding intracellular membrane-bounded organelle UMP salvage CTP salvage uc007dku.1 uc007dku.2 uc007dku.3 uc007dku.4 uc007dku.5 
ENSMUST00000053699.13 Secisbp2l ENSMUST00000053699.13 SECIS binding protein 2-like, transcript variant 2 (from RefSeq NM_177608.3) A2AQE2 A2AQE2_MOUSE ENSMUST00000053699.1 ENSMUST00000053699.10 ENSMUST00000053699.11 ENSMUST00000053699.12 ENSMUST00000053699.2 ENSMUST00000053699.3 ENSMUST00000053699.4 ENSMUST00000053699.5 ENSMUST00000053699.6 ENSMUST00000053699.7 ENSMUST00000053699.8 ENSMUST00000053699.9 NM_177608 Secisbp2l uc008mcz.1 uc008mcz.2 selenocysteine insertion sequence binding uc008mcz.1 uc008mcz.2 
ENSMUST00000053705.8 B4gat1 ENSMUST00000053705.8 beta-1,4-glucuronyltransferase 1 (from RefSeq NM_175383.2) B3gnt1 B3gnt6 B4GA1_MOUSE B4gat1 ENSMUST00000053705.1 ENSMUST00000053705.2 ENSMUST00000053705.3 ENSMUST00000053705.4 ENSMUST00000053705.5 ENSMUST00000053705.6 ENSMUST00000053705.7 NM_175383 Q3TY43 Q8BJH9 Q8BWP8 Q99LW7 uc008gbx.1 uc008gbx.2 uc008gbx.3 uc008gbx.4 Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1) (PubMed:23217742, PubMed:25279699). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O- mannosyl glycan (PubMed:25279699). Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (PubMed:23217742). Reaction=3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc- (1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP- alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib- ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P- alpha-D-Man)]-Thr-[protein] + H(+) + UDP; Xref=Rhea:RHEA:46860, Rhea:RHEA-COMP:15023, Rhea:RHEA-COMP:17482, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:142405, ChEBI:CHEBI:177336; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Interacts with LARGE1 and LARGE2. Golgi apparatus membrane ; Single-pass type II membrane protein. Note=Localizes near the trans-Golgi apparatus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BWP8-1; Sequence=Displayed; Name=2; IsoId=Q8BWP8-2; Sequence=VSP_014004, VSP_014005; Early embryonic lethality. Belongs to the glycosyltransferase 49 family. Golgi membrane Golgi apparatus protein glycosylation axon guidance glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein O-linked mannosylation metal ion binding N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity poly-N-acetyllactosamine biosynthetic process uc008gbx.1 uc008gbx.2 uc008gbx.3 uc008gbx.4 
ENSMUST00000053708.9 Klre1 ENSMUST00000053708.9 killer cell lectin-like receptor family E member 1, transcript variant 1 (from RefSeq NM_153590.3) ENSMUST00000053708.1 ENSMUST00000053708.2 ENSMUST00000053708.3 ENSMUST00000053708.4 ENSMUST00000053708.5 ENSMUST00000053708.6 ENSMUST00000053708.7 ENSMUST00000053708.8 KLRE1_MOUSE Klre1 NKG2I NM_153590 Q80WP0 Q8CJC7 uc009egb.1 uc009egb.2 uc009egb.3 Lectin-like receptor for natural killer (NK) cells (PubMed:14707119, PubMed:15069013, PubMed:18713988). Can either inhibit or activate NK cell cytotoxic activity, depending on its binding partner (PubMed:14707119, PubMed:15069013, PubMed:18713988). Heterodimer formation with KLRI1 mediates NK cell inhibition whereas heterodimer formation with KLRI2 mediates NK cell activation (PubMed:18713988). Plays a role in allogeneic recognition by the immune system (PubMed:14707119, PubMed:15069013). Heterodimer; with KLRI1 or KLRI2. Cell membrane ingle-pass type II membrane protein Expressed in natural killer (NK) cells (at protein level) (PubMed:12782717, PubMed:14707119, PubMed:12715246). Also detected in natural killer T (NKT) cells (at protein level) (PubMed:14707119, PubMed:12715246). Has little or no expression in T cells (at protein level) (PubMed:14707119, PubMed:12715246). Viable and fertile, with no gross abnormalities. Development of natural killer (NK) cells appears to be normal. Cytolytic activity of activated NK cells against allogeneic target cells is significantly reduced. stimulatory C-type lectin receptor signaling pathway negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target transmembrane signaling receptor activity plasma membrane integral component of plasma membrane external side of plasma membrane cell surface membrane integral component of membrane protein phosphatase binding natural killer cell activation carbohydrate binding positive regulation of interferon-gamma production identical protein binding protein homodimerization activity positive regulation of natural killer cell mediated cytotoxicity uc009egb.1 uc009egb.2 uc009egb.3 
ENSMUST00000053713.5 Irf2bp1 ENSMUST00000053713.5 interferon regulatory factor 2 binding protein 1 (from RefSeq NM_178757.4) ENSMUST00000053713.1 ENSMUST00000053713.2 ENSMUST00000053713.3 ENSMUST00000053713.4 I2BP1_MOUSE NM_178757 Q8BJC9 Q8C0B1 Q8CI76 Q8R3Y8 uc009fkc.1 uc009fkc.2 uc009fkc.3 Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP2. Interacts with JDP2. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R3Y8-1; Sequence=Displayed; Name=2; IsoId=Q8R3Y8-2; Sequence=VSP_032768; Belongs to the IRF2BP family. negative regulation of transcription from RNA polymerase II promoter protein polyubiquitination RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription corepressor activity nucleus nucleoplasm transcription factor binding transferase activity positive regulation of transcription from RNA polymerase II promoter metal ion binding ubiquitin protein ligase activity uc009fkc.1 uc009fkc.2 uc009fkc.3 
ENSMUST00000053716.8 Clrn3 ENSMUST00000053716.8 clarin 3 (from RefSeq NM_178669.5) CLRN3_MOUSE ENSMUST00000053716.1 ENSMUST00000053716.2 ENSMUST00000053716.3 ENSMUST00000053716.4 ENSMUST00000053716.5 ENSMUST00000053716.6 ENSMUST00000053716.7 NM_178669 Q8BHH8 Tmem12 uc009ked.1 uc009ked.2 uc009ked.3 Membrane ; Multi-pass membrane protein Belongs to the clarin family. molecular_function biological_process membrane integral component of membrane uc009ked.1 uc009ked.2 uc009ked.3 
ENSMUST00000053729.14 Pdss1 ENSMUST00000053729.14 prenyl (solanesyl) diphosphate synthase, subunit 1, transcript variant 3 (from RefSeq NR_149721.2) B8JJW9 DPS1_MOUSE Dps1 ENSMUST00000053729.1 ENSMUST00000053729.10 ENSMUST00000053729.11 ENSMUST00000053729.12 ENSMUST00000053729.13 ENSMUST00000053729.2 ENSMUST00000053729.3 ENSMUST00000053729.4 ENSMUST00000053729.5 ENSMUST00000053729.6 ENSMUST00000053729.7 ENSMUST00000053729.8 ENSMUST00000053729.9 NR_149721 Pdss1 Q33DR2 Q9WU69 Sps1 Tprt uc008inq.1 uc008inq.2 uc008inq.3 uc008inq.4 Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone (PubMed:16262699). Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively (PubMed:16262699). The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry (PubMed:16262699). Reaction=(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate; Xref=Rhea:RHEA:27802, ChEBI:CHEBI:33019, ChEBI:CHEBI:60721, ChEBI:CHEBI:128769, ChEBI:CHEBI:175763; EC=2.5.1.91; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27803; Evidence=; Reaction=(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate; Xref=Rhea:RHEA:55364, ChEBI:CHEBI:33019, ChEBI:CHEBI:58391, ChEBI:CHEBI:128769, ChEBI:CHEBI:175763; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55365; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 Mg(2+) ions per subunit. ; Cofactor biosynthesis; ubiquinone biosynthesis. Heterotetramer composed of 2 PDSS1/DPS1 and 2 PDSS2/DLP1 subunits. Mitochondrion Belongs to the FPP/GGPP synthase family. Sequence=AAD24462.1; Type=Erroneous initiation; Evidence=; Sequence=AAH26820.1; Type=Erroneous initiation; Evidence=; trans-hexaprenyltranstransferase activity protein binding mitochondrion ubiquinone biosynthetic process isoprenoid biosynthetic process transferase activity metal ion binding protein heterodimerization activity transferase complex trans-octaprenyltranstransferase activity uc008inq.1 uc008inq.2 uc008inq.3 uc008inq.4 
ENSMUST00000053737.9 Sfswap ENSMUST00000053737.9 splicing factor SWAP, transcript variant 1 (from RefSeq NM_172276.3) ENSMUST00000053737.1 ENSMUST00000053737.2 ENSMUST00000053737.3 ENSMUST00000053737.4 ENSMUST00000053737.5 ENSMUST00000053737.6 ENSMUST00000053737.7 ENSMUST00000053737.8 NM_172276 Q3USH5 Q8CCZ1 SFSWA_MOUSE Sfrs8 Srsf8 Swap uc008zsv.1 uc008zsv.2 uc008zsv.3 Plays a role as an alternative splicing regulator. Regulates its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10 (By similarity). Q3USH5; Q15637: SF1; Xeno; NbExp=3; IntAct=EBI-8387273, EBI-744603; Nucleus alternative mRNA splicing, via spliceosome mRNA 5'-splice site recognition RNA binding protein binding nucleus RNA processing mRNA processing RNA splicing negative regulation of mRNA splicing, via spliceosome uc008zsv.1 uc008zsv.2 uc008zsv.3 
ENSMUST00000053743.6 Ubqln5 ENSMUST00000053743.6 ubiquilin 5 (from RefSeq NM_027634.1) 4931431F19Rik ENSMUST00000053743.1 ENSMUST00000053743.2 ENSMUST00000053743.3 ENSMUST00000053743.4 ENSMUST00000053743.5 NM_027634 Q9D4I8 Q9D4I8_MOUSE Ubqln5 uc012frf.1 uc012frf.2 uc012frf.3 mitochondrion cytosol ubiquitin-dependent protein catabolic process polyubiquitin binding uc012frf.1 uc012frf.2 uc012frf.3 
ENSMUST00000053744.9 Riox1 ENSMUST00000053744.9 ribosomal oxygenase 1 (from RefSeq NM_023633.3) B2RQV2 ENSMUST00000053744.1 ENSMUST00000053744.2 ENSMUST00000053744.3 ENSMUST00000053744.4 ENSMUST00000053744.5 ENSMUST00000053744.6 ENSMUST00000053744.7 ENSMUST00000053744.8 MNCb-7109 Mapjd NM_023633 No66 Q9JJF3 RIOX1_MOUSE Riox1 uc007odz.1 uc007odz.2 uc007odz.3 uc007odz.4 Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:19927124). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (PubMed:19927124). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (PubMed:19927124). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (PubMed:19927124). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (PubMed:35210392). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (By similarity). Participates in MYC- induced transcriptional activation (By similarity). Reaction=2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:42032, Rhea:RHEA-COMP:9785, Rhea:RHEA- COMP:9787, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61976; EC=1.14.11.27; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42033; Evidence=; Reaction=2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + L-lysyl-[protein] + succinate; Xref=Rhea:RHEA:60924, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13053, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60925; Evidence=; Reaction=2-oxoglutarate + L-histidyl-[protein] + O2 = (3S)-3-hydroxy-L- histidyl-[protein] + CO2 + succinate; Xref=Rhea:RHEA:54256, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:13840, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29979, ChEBI:CHEBI:30031, ChEBI:CHEBI:138021; EC=1.14.11.79; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54257; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Interacts with SP7/OSX; the interaction is direct (PubMed:19927124). Interacts with PHF19; leading to its recruitment to H3K36me3 sites (By similarity). Interacts with MYC (By similarity). Q9JJF3; Q8VI67: Sp7; NbExp=3; IntAct=EBI-7608809, EBI-7608836; Nucleus, nucleolus Nucleus, nucleoplasm Present in developing bones (at protein level) (PubMed:19927124). Widely but not ubiquitously expressed (PubMed:19927124). Belongs to the ROX family. NO66 subfamily. iron ion binding protein binding nucleus nucleoplasm nucleolus chromatin organization chromatin remodeling oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors histone demethylase activity (H3-K4 specific) histone H3-K4 demethylation ribosome biogenesis negative regulation of osteoblast differentiation negative regulation of transcription, DNA-templated metal ion binding dioxygenase activity histone demethylase activity (H3-K36 specific) oxidation-reduction process histone H3-K36 demethylation uc007odz.1 uc007odz.2 uc007odz.3 uc007odz.4 
ENSMUST00000053748.16 Epb41l2 ENSMUST00000053748.16 erythrocyte membrane protein band 4.1 like 2, transcript variant 38 (from RefSeq NM_001404841.1) E41L2_MOUSE ENSMUST00000053748.1 ENSMUST00000053748.10 ENSMUST00000053748.11 ENSMUST00000053748.12 ENSMUST00000053748.13 ENSMUST00000053748.14 ENSMUST00000053748.15 ENSMUST00000053748.2 ENSMUST00000053748.3 ENSMUST00000053748.4 ENSMUST00000053748.5 ENSMUST00000053748.6 ENSMUST00000053748.7 ENSMUST00000053748.8 ENSMUST00000053748.9 Epb4.1l2 Epb41l2 G3X9B8 NM_001404841 O70318 uc007erk.1 uc007erk.2 uc007erk.3 uc007erk.4 uc007erk.5 Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. Interacts with FCGR1A. Interacts with TRPC4 (By similarity). Interacts (via CTD domain) with FKBP2 (PubMed:9531554). Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes anaphase-specific localization of NUMA1 in symmetrically dividing cells (By similarity). O70318; Q9JLB0: Pals2; NbExp=3; IntAct=EBI-643339, EBI-771456; Cytoplasm, cytoskeleton Cytoplasm, cell cortex Cell membrane Widely expressed. actin binding structural molecule activity protein binding nucleus nucleoplasm cytoplasm cytoskeleton plasma membrane cell cortex cell cycle cytoskeletal protein binding COP9 signalosome regulation of cell shape actin cytoskeleton membrane actin cytoskeleton organization cell junction spectrin binding cortical actin cytoskeleton organization actomyosin structure organization PH domain binding cell division cell cortex region positive regulation of protein localization to cell cortex uc007erk.1 uc007erk.2 uc007erk.3 uc007erk.4 uc007erk.5 
ENSMUST00000053753.8 Gja4 ENSMUST00000053753.8 gap junction protein, alpha 4 (from RefSeq NM_008120.3) Cxnh1 ENSMUST00000053753.1 ENSMUST00000053753.2 ENSMUST00000053753.3 ENSMUST00000053753.4 ENSMUST00000053753.5 ENSMUST00000053753.6 ENSMUST00000053753.7 Gja4 NM_008120 Q3UPZ2 Q3UPZ2_MOUSE uc008uur.1 uc008uur.2 uc008uur.3 uc008uur.4 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Cell junction, gap junction Cell membrane ; Multi- pass membrane protein mbrane ; Multi-pass membrane protein Belongs to the connexin family. endothelium development plasma membrane gap junction connexin complex calcium ion transport cell communication cell-cell signaling membrane integral component of membrane cell junction response to pain uc008uur.1 uc008uur.2 uc008uur.3 uc008uur.4 
ENSMUST00000053760.12 Utp14b ENSMUST00000053760.12 UTP14B small subunit processome component, transcript variant 4 (from RefSeq NM_001409067.1) E9Q9S3 E9Q9S3_MOUSE ENSMUST00000053760.1 ENSMUST00000053760.10 ENSMUST00000053760.11 ENSMUST00000053760.2 ENSMUST00000053760.3 ENSMUST00000053760.4 ENSMUST00000053760.5 ENSMUST00000053760.6 ENSMUST00000053760.7 ENSMUST00000053760.8 ENSMUST00000053760.9 NM_001409067 Utp14b uc007bqn.1 uc007bqn.2 uc007bqn.3 uc007bqn.4 Nucleus, nucleolus Belongs to the UTP14 family. rRNA processing small-subunit processome uc007bqn.1 uc007bqn.2 uc007bqn.3 uc007bqn.4 
ENSMUST00000053764.7 Foxo1 ENSMUST00000053764.7 forkhead box O1 (from RefSeq NM_019739.3) ENSMUST00000053764.1 ENSMUST00000053764.2 ENSMUST00000053764.3 ENSMUST00000053764.4 ENSMUST00000053764.5 ENSMUST00000053764.6 FOXO1_MOUSE Fkhr Foxo1a NM_019739 Q9JJW4 Q9R1E0 uc008pei.1 uc008pei.2 uc008pei.3 uc008pei.4 Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:12219087, PubMed:12754525, PubMed:15184386, PubMed:15220471, PubMed:16917544, PubMed:17090532, PubMed:17627282, PubMed:17681146, PubMed:20519497, PubMed:20668652, PubMed:21196578, PubMed:21335550, PubMed:21471200, PubMed:22298775, PubMed:22417654, PubMed:22510882, PubMed:27457971, PubMed:34914893). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG- 3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:17090532, PubMed:21335550). Activity suppressed by insulin (PubMed:12754525, PubMed:17627282). Main regulator of redox balance and osteoblast numbers and controls bone mass (PubMed:21471200, PubMed:22298775). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (PubMed:21471200, PubMed:22298775). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (PubMed:32103177). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (PubMed:22298775). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (PubMed:21471200). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (PubMed:12219087, PubMed:27457971). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (PubMed:12754525, PubMed:25009184). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (By similarity). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (By similarity). Promotes neural cell death (By similarity). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (PubMed:21196578). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (By similarity). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). Interacts with EP300 and CREBBP; the interactions acetylate FOXO1. Interacts with the 14-3-3 proteins, YWHAG and YWHAZ; the interactions require insulin-stimulated phosphorylation on Thr-24, promote nuclear exit and loss of transcriptional activity. Interacts with SKP2; the interaction ubiquitinates FOXO1 leading to its proteasomal degradation. Interacts with PMRT1; methylates FOXO1, prevents PKB/AKT1 phosphorylation and retains FOXO1 in the nucleus (By similarity). Interacts (via an N-terminal domain) with FCOR; the interaction is direct, occurs in a forskolin-independent manner and prevents SIRT1 binding to FOXO1. Interacts (via the C-terminal half) with ATF4 (via its DNA-binding domain); the interaction occurs in osteoblasts, regulates glucose homeostasis via suppression of beta-cell proliferation and subsequent decrease in insulin production. Interacts with RUNX2; the interaction inhibits RUNX2 transcriptional activity and mediates the IGF1/insulin-dependent BGLAP expression in osteoblasts. Interacts with PPP2R1A; the interaction regulates the dephosphorylation of FOXO1 at Thr-24 and Ser-253 leading to its nuclear import. Binds to CDK1. Interacts with LRPPRC. Interacts with RUNX2; the interaction inhibits RUNX2 transcriptional activity and mediates the IGF1/insulin- dependent BGLAP expression in osteoblasts. Interacts with NLK. Interacts with SIRT1; the interaction results in the deacetylation of FOXO1 leading to activation of FOXO1-mediated transcription of genes involved in DNA repair and stress resistance. The interaction requires the presence of KRIT1 and is inhibited by FCOR. Interacts with SIRT2; the interaction is disrupted in response to oxidative stress or serum deprivation, leading to increased level of acetylated FOXO1, which promotes stress-induced autophagy by stimulating E1-like activating enzyme ATG7. Interacts (acetylated form) with ATG7; the interaction is increased in response to oxidative stress or serum deprivation and promotes the autophagic process leading to cell death. Interacts (acetylated form) with PPARG (PubMed:12754525, PubMed:15220471, PubMed:16917544, PubMed:17050673, PubMed:17681146, PubMed:19037106, PubMed:20061393, PubMed:20668652, PubMed:21471200, PubMed:22298775, PubMed:22417654, PubMed:22510882). Interacts with XBP1 isoform 2; this interaction is direct and leads to FOXO1 ubiquitination and degradation via the proteasome pathway (PubMed:21317886). Interacts (via the Fork- head domain) with CEBPA; the interaction increases when FOXO1 is deacetylated (PubMed:17090532, PubMed:17627282). Interacts with WDFY2 (PubMed:18388859). Forms a complex with WDFY2 and AKT1 (PubMed:18388859). Interacts with CRY1 (PubMed:28790135). Interacts with PPIA/CYPA; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with TOX4; FOXO1 is required for full induction of TOX4- dependent activity and the interaction is inhibited by insulin (PubMed:34914893). Q9R1E0; P53566: Cebpa; NbExp=5; IntAct=EBI-1371343, EBI-2644207; Q9R1E0; P0DJI6: Fcor; NbExp=12; IntAct=EBI-1371343, EBI-6126630; Q9R1E0; Q6PB66: Lrpprc; NbExp=2; IntAct=EBI-1371343, EBI-1371262; Q9R1E0; P51450-2: Rorc; NbExp=2; IntAct=EBI-1371343, EBI-4422078; Q9R1E0; P10275: AR; Xeno; NbExp=4; IntAct=EBI-1371343, EBI-608057; Q9R1E0; Q96EB6: SIRT1; Xeno; NbExp=2; IntAct=EBI-1371343, EBI-1802965; Cytoplasm cleus te=Shuttles between the cytoplasm and nucleus (PubMed:32103177). Largely nuclear in unstimulated cells (By similarity). In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (PubMed:22298775). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (PubMed:32103177). Insulin-induced phosphorylation at Ser-253 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteasomal pathway (By similarity). Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation (By similarity). Phosphorylation by NLK results in nuclear export (PubMed:20061393). Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1 (By similarity). SGK1-mediated phosphorylation also results in nuclear translocation (PubMed:19965929). Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide (PubMed:21196578). Methylated form is nuclear (PubMed:18951090). PPIA/CYPA stimulates its nuclear accumulation (By similarity). Deacetylation by SIRT6, promotes its translocation into the cytoplasm (PubMed:27457971). Expressed in liver, white and brown adipose tissues (at protein level). In liver, barely expressed at 14.5 dpc, expression dramatically increases at 18.5 dpc. Abundantly expressed in neonate liver but levels strongly decrease in adult liver (at protein level). Expression is regulated by KRIT1 (PubMed:20668652). Transiently up-regulated during adipogenesis (at protein level) (PubMed:18388859). Phosphorylation by NLK promotes nuclear export and inhibits the transcriptional activity. In response to growth factors, phosphorylation on Thr-24, Ser-253 and Ser-319 by PKB/AKT1 promotes nuclear export and inactivation of transactivational activity. Phosphorylation on Thr-24 is required for binding 14-3-3 proteins. Phosphorylation of Ser-253 decreases DNA-binding activity and promotes the phosphorylation of Thr-24 and Ser-316, permitting phosphorylation of Ser-319 and Ser-322, probably by CDK1, leading to nuclear exclusion and loss of function. Stress signals, such as response to oxygen or nitric oxide, attenuate the PKB/AKT1-mediated phosphorylation leading to nuclear retention. Phosphorylation of Ser-326 is independent of IGF1 and leads to reduced function. Dephosphorylated on Thr-24 and Ser-253 by PP2A in beta-cells under oxidative stress leading to nuclear retention (By similarity). Phosphorylation of Ser-246 by CDK1 disrupts binding of 14-3-3 proteins leading to nuclear accumulation and has no effect on DNA-binding nor transcriptional activity. Phosphorylation by STK4/MST1 on Ser-209, upon oxidative stress, inhibits binding to 14-3-3 proteins and nuclear export (By similarity). PPIA/CYPA promotes its dephosphorylation on Ser-253 (By similarity). Ubiquitinated, leading to proteasomal degradation (PubMed:28790135). Ubiquitinated by SKP2 (By similarity). Methylation inhibits PKB/AKT1-mediated phosphorylation at Ser-253, promoting nuclear retention and increasing the transcriptional activity and cell death. Methylation increased by oxidative stress. Acetylation at Lys-259 and Lys-271 are necessary for autophagic cell death induction (By similarity). Deacetylated by SIRT2 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagic cell death (By similarity). Once in the nucleus, acetylated by CREBBP/EP300 (By similarity). Acetylation diminishes the interaction with target DNA and attenuates the transcriptional activity. It increases the phosphorylation at Ser-253, and is required for the transcriptional inhibition by FCOR (By similarity). Deacetylation by SIRT1 results in reactivation of the transcriptional activity (PubMed:15220471, PubMed:16076959, PubMed:17090532). Acetylation of FOXO1 diminishes its binding to PPARG in adipocytes. Deacetylated by SIRT2; deacetylation of FOXO1 directly increases its repressive binding to PPARG and inhibits adipocyte differentiation (PubMed:17681146, PubMed:19037106, PubMed:20519497, PubMed:21196578). Oxidative stress by hydrogen peroxide treatment appears to promote deacetylation and uncoupling of insulin-induced phosphorylation (By similarity). By contrast, resveratrol acts independently of acetylation (By similarity). Acetylated at Lys-420, promoting its localization to the nucleus and transcription factor activity (PubMed:25009184). Deacetylation at Lys-420 by SIRT6, promotes its translocation into the cytoplasm, preventing its transcription factor activity (PubMed:25009184, PubMed:27457971). Deacetylation and subsequent inhibition by SIRT6 has different effects depending on cell types: it inhibits gluconeogenesis in hepatocytes, promotes glucose sensing in pancreatic beta-cells and regulates lipid catabolism in brown adipocytes (PubMed:25009184, PubMed:27457971, PubMed:31442424). Null mice die around embryonic day 11 and exhibit abnormal angiogenesis. Defects are observed in branchial arches and there is remarkably impaired vascular development of embryos and yolk sacs. Exogeneous VEGF on FOX1-deficient endothelial cells show markedly different morphological response. Active osteocalcin/BGLAP as well as serum insulin and beta-cell and gonadal fat levels were increased, but there is no change in total fat content, lean mass, and body weight. Effect on RUNX2 activity was inhibited. FOXO1 and ATF4 double happlo- insufficient mice exhibit also an increase in insulin levels and beta cell proliferation, but there is an increase in insulin sensitivity demonstrated by an increase in expression of insulin-sensitizing hormone adiponectin. Gonadal fat levels and adipocyte numbers were decreased. Osteocalcin/BGLAP levels were unchanged. In an animal model of diabetes mellitus type 2 (db/db mice), beta-cell islets exhibit increased levels of PPP2R1A leading to increased dephosphorylation at Thr-24 and Ser-253 and nuclear retention of FOXO1. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding blood vessel development DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter autophagy apoptotic process cellular response to DNA damage stimulus beta-catenin binding transcription factor binding insulin receptor signaling pathway cellular response to starvation positive regulation of autophagy cell differentiation ubiquitin protein ligase binding response to insulin cellular response to insulin stimulus negative regulation of stress-activated MAPK cascade cellular response to oxidative stress regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter regulation of cell proliferation glucose homeostasis positive regulation of apoptotic process negative regulation of apoptotic process sequence-specific DNA binding negative regulation of fat cell differentiation positive regulation of gluconeogenesis positive regulation of protein catabolic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein phosphatase 2A binding enamel mineralization cellular response to hydrogen peroxide cellular response to hyperoxia cellular response to dexamethasone stimulus cellular response to nitric oxide negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance response to fluoride negative regulation of cardiac muscle hypertrophy in response to stress regulation of neural precursor cell proliferation regulation of reactive oxygen species metabolic process uc008pei.1 uc008pei.2 uc008pei.3 uc008pei.4 
ENSMUST00000053766.14 Amfr ENSMUST00000053766.14 autocrine motility factor receptor, transcript variant 9 (from RefSeq NR_182267.1) AMFR_MOUSE ENSMUST00000053766.1 ENSMUST00000053766.10 ENSMUST00000053766.11 ENSMUST00000053766.12 ENSMUST00000053766.13 ENSMUST00000053766.2 ENSMUST00000053766.3 ENSMUST00000053766.4 ENSMUST00000053766.5 ENSMUST00000053766.6 ENSMUST00000053766.7 ENSMUST00000053766.8 ENSMUST00000053766.9 NR_182267 Q8K008 Q99LH5 Q9R049 uc009mvn.1 uc009mvn.2 uc009mvn.3 E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:16987818, PubMed:18216283). Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:16987818, PubMed:18216283). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:22863805). In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (By similarity). The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction (By similarity). In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (By similarity). Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (By similarity). Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (By similarity). Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (By similarity). Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (By similarity). Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:12650607). In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation (By similarity). Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.; EC=2.3.2.36; Evidence=; Protein modification; protein ubiquitination. Interacts with RNF5. Also forms an ERAD complex containing VCP/p97, NGLY1; PSMC1; SAKS1 and RAD23B required for coupling retrotranslocation, ubiquitination and deglycosylation. Interacts with DERL1. Interacts (through a region distinct from the RING finger) with UBE2G2/UBC7. Component of the VCP/p97-AMFR/gp78 complex that enhances VCP/p97 binding to polyubiquitinated proteins for their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway. Interacts (via the VIM) with VCP/p97. Interacts (via its membrane domain) with INSIG1; the interaction initiates the sterol-mediated ubiquitination and degradation of HMGCR by the ERAD pathway. Interacts with AUP1, UBE2G2 and RNF139/TRC8; interaction with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced ubiquitination of HNGCR and its subsequent proteasomal degradation (By similarity). Interacts with BAG6. Interacts with USP13 (via UBA 2 domain); the interaction is direct (By similarity). Interacts with LMBR1L, UBAC2 and CTNNB1 (PubMed:31073040). Interacts with C18orf32 (By similarity). Q9R049; Q9JI78: Ngly1; NbExp=5; IntAct=EBI-3648125, EBI-3648128; Q9R049; Q01853: Vcp; NbExp=4; IntAct=EBI-3648125, EBI-80597; Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Palmitoylation promotes localization to the peripheral endoplasmic reticulum. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q9R049-1; Sequence=Displayed; Name=2 ; IsoId=Q9R049-2; Sequence=VSP_008224; Expressed in heart, brain, liver, lung, skeletal muscle, kidney and testis. Not detected in spleen. The CUE domain is required for recognition of misfolded proteins such as mutant CFTR. The VCP/p97-interacting motif (VIM) is sufficient for binding VCP/p97 to form a complex capable of transferring VCP/p97 from the cytosol to microsomes. Palmitoylation of the RING-type zing finger by ZDHHC6 promotes localization to the peripheral endoplasmic reticulum. Mice with a conditional deletion in the liver display improved hyperlipidemia and insulin resistance: mice show elevated energy expenditure and are resistant to diet-induced obesity and glucose intolerance (PubMed:22863805). Increased stability of Hmgcr, Insig1 and Insig2 and suppression of the SREBP pathway and novo lipid biosynthesis (PubMed:22863805). ubiquitin ligase complex nucleotide binding protein polyubiquitination ubiquitin-protein transferase activity protein binding nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol integral component of plasma membrane ubiquitin-dependent protein catabolic process aging learning or memory cellular process membrane integral component of membrane protein ubiquitination transferase activity integral component of endoplasmic reticulum membrane dendrite growth cone ER-associated ubiquitin-dependent protein catabolic process protein binding, bridging endoplasmic reticulum unfolded protein response positive regulation of protein binding macromolecular complex ubiquitin-ubiquitin ligase activity Derlin-1 retrotranslocation complex signaling receptor activity identical protein binding neuronal cell body metal ion binding perinuclear region of cytoplasm chaperone binding protein oligomerization protein autoubiquitination ubiquitin protein ligase activity protein K48-linked ubiquitination BAT3 complex binding ubiquitin-specific protease binding uc009mvn.1 uc009mvn.2 uc009mvn.3 
ENSMUST00000053768.14 Stxbp6 ENSMUST00000053768.14 syntaxin binding protein 6 (amisyn), transcript variant 7 (from RefSeq NR_177244.1) ENSMUST00000053768.1 ENSMUST00000053768.10 ENSMUST00000053768.11 ENSMUST00000053768.12 ENSMUST00000053768.13 ENSMUST00000053768.2 ENSMUST00000053768.3 ENSMUST00000053768.4 ENSMUST00000053768.5 ENSMUST00000053768.6 ENSMUST00000053768.7 ENSMUST00000053768.8 ENSMUST00000053768.9 NR_177244 Q3TYA4 Q3TYA4_MOUSE Stxbp6 uc007nmc.1 uc007nmc.2 uc007nmc.3 membrane integral component of membrane vesicle-mediated transport regulation of SNARE complex assembly uc007nmc.1 uc007nmc.2 uc007nmc.3 
ENSMUST00000053771.14 Phkb ENSMUST00000053771.14 phosphorylase kinase beta, transcript variant 9 (from RefSeq NR_175780.1) ENSMUST00000053771.1 ENSMUST00000053771.10 ENSMUST00000053771.11 ENSMUST00000053771.12 ENSMUST00000053771.13 ENSMUST00000053771.2 ENSMUST00000053771.3 ENSMUST00000053771.4 ENSMUST00000053771.5 ENSMUST00000053771.6 ENSMUST00000053771.7 ENSMUST00000053771.8 ENSMUST00000053771.9 KPBB_MOUSE NR_175780 Q7TSH2 uc009mqj.1 uc009mqj.2 uc009mqj.3 Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation (By similarity). By phosphorylation of various serine residues. Glycan biosynthesis; glycogen metabolism. Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated. Belongs to the phosphorylase b kinase regulatory chain family. catalytic activity phosphorylase kinase activity calmodulin binding plasma membrane phosphorylase kinase complex carbohydrate metabolic process glycogen metabolic process protein phosphorylation membrane uc009mqj.1 uc009mqj.2 uc009mqj.3 
ENSMUST00000053811.10 Dlst ENSMUST00000053811.10 dihydrolipoamide S-succinyltransferase (from RefSeq NM_030225.4) Dlst ENSMUST00000053811.1 ENSMUST00000053811.2 ENSMUST00000053811.3 ENSMUST00000053811.4 ENSMUST00000053811.5 ENSMUST00000053811.6 ENSMUST00000053811.7 ENSMUST00000053811.8 ENSMUST00000053811.9 NM_030225 ODO2_MOUSE Q3UEA0 Q4FK55 Q8CIE8 Q9D2G2 uc007ogj.1 uc007ogj.2 uc007ogj.3 uc007ogj.4 Dihydrolipoamide succinyltransferase (E2) component of the 2- oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2- oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2- oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl- CoA to histone succinyltransferase KAT2A (By similarity). Reaction=N(6)-[(R)-dihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = CoA + N(6)-[(R)-S(8)- succinyldihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2]; Xref=Rhea:RHEA:15213, Rhea:RHEA-COMP:10581, Rhea:RHEA- COMP:10582, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:83100, ChEBI:CHEBI:83120; EC=2.3.1.61; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:15215; Evidence=; Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence=; Note=Binds 1 lipoyl cofactor covalently. ; Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6. Carbohydrate metabolism; tricarboxylic acid cycle. The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2), DLD (dihydrolipoamide dehydrogenase; E3) and the assembly factor KGD4 (PubMed:36854377). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A. Interacts with ABHD11; this interaction maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (By similarity). Q9D2G2; Q9QXS1: Plec; NbExp=2; IntAct=EBI-773210, EBI-774583; Mitochondrion matrix Nucleus Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D2G2-1; Sequence=Displayed; Name=2; IsoId=Q9D2G2-2; Sequence=VSP_025015, VSP_025016; Belongs to the 2-oxoacid dehydrogenase family. dihydrolipoyllysine-residue succinyltransferase activity protein binding nucleus mitochondrion mitochondrial matrix plasma membrane tricarboxylic acid cycle 2-oxoglutarate metabolic process succinyl-CoA metabolic process NADH metabolic process transferase activity transferase activity, transferring acyl groups heat shock protein binding L-lysine catabolic process to acetyl-CoA via saccharopine myelin sheath intracellular membrane-bounded organelle oxoglutarate dehydrogenase complex chaperone binding uc007ogj.1 uc007ogj.2 uc007ogj.3 uc007ogj.4 
ENSMUST00000053819.6 Srsf4 ENSMUST00000053819.6 serine and arginine-rich splicing factor 4, transcript variant 5 (from RefSeq NM_020587.2) ENSMUST00000053819.1 ENSMUST00000053819.2 ENSMUST00000053819.3 ENSMUST00000053819.4 ENSMUST00000053819.5 NM_020587 Q542V3 Q542V3_MOUSE Sfrs4 Srsf4 uc008vaf.1 uc008vaf.2 uc008vaf.3 uc008vaf.4 The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]. ##Evidence-Data-START## Transcript exon combination :: AK077648.1, AK075769.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## nucleic acid binding RNA binding nucleus nuclear speck response to insulin negative regulation of mRNA splicing, via spliceosome sequence-specific mRNA binding uc008vaf.1 uc008vaf.2 uc008vaf.3 uc008vaf.4 
ENSMUST00000053821.5 AY358078 ENSMUST00000053821.5 cDNA sequence AY358078 (from RefSeq NM_194347.1) AY358078 D17Ertd441e ENSMUST00000053821.1 ENSMUST00000053821.2 ENSMUST00000053821.3 ENSMUST00000053821.4 Hn1l NM_194347 Q6UY53 Q6UY53_MOUSE uc007tne.1 uc007tne.2 molecular_function cellular_component biological_process uc007tne.1 uc007tne.2 
ENSMUST00000053830.5 Hmgb4 ENSMUST00000053830.5 high-mobility group box 4 (from RefSeq NM_027036.3) ENSMUST00000053830.1 ENSMUST00000053830.2 ENSMUST00000053830.3 ENSMUST00000053830.4 HMGB4_MOUSE NM_027036 Q6P8W9 Q9DAR4 uc008uva.1 uc008uva.2 uc008uva.3 Nucleus Chromosome Note=Interacts specifically with the sex chromosomes. Expressed in adult germ cells (at protein level). Strongly expressed in adult germ cells and weakly expressed embryonic gonads (PubMed:25609838). In meiotic germ cells, begins to accumulate during the leptotene stage, before its concentration increases further during the pachytene and diplotene stages, where it localizes to the sex body (PubMed:25609838). Belongs to the HMGB family. nuclear chromatin activation of innate immune response DNA binding nucleus chromosome cytoplasm DNA recombination regulation of transcription from RNA polymerase II promoter transcription factor binding DNA binding, bending regulation of receptor activity positive regulation of autophagy developmental process positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of innate immune response positive regulation of transcription from RNA polymerase II promoter positive regulation of interleukin-1 secretion positive regulation of interleukin-1 beta secretion cell chemotaxis positive regulation of ERK1 and ERK2 cascade positive regulation of NIK/NF-kappaB signaling positive regulation of interferon-alpha secretion uc008uva.1 uc008uva.2 uc008uva.3 
ENSMUST00000053855.8 Ddit4l ENSMUST00000053855.8 DNA-damage-inducible transcript 4-like (from RefSeq NM_030143.4) DDT4L_MOUSE ENSMUST00000053855.1 ENSMUST00000053855.2 ENSMUST00000053855.3 ENSMUST00000053855.4 ENSMUST00000053855.5 ENSMUST00000053855.6 ENSMUST00000053855.7 NM_030143 Q8C0Z7 Q8VD49 Q8VHZ5 Q9CQV2 Rtp801l Smhs1 uc008rmn.1 uc008rmn.2 uc008rmn.3 uc008rmn.4 Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Cytoplasm Belongs to the DDIT4 family. molecular_function cellular_component cytoplasm biological_process negative regulation of signal transduction uc008rmn.1 uc008rmn.2 uc008rmn.3 uc008rmn.4 
ENSMUST00000053856.6 Pcdhb17 ENSMUST00000053856.6 protocadherin beta 17 (from RefSeq NM_053142.4) ENSMUST00000053856.1 ENSMUST00000053856.2 ENSMUST00000053856.3 ENSMUST00000053856.4 ENSMUST00000053856.5 NM_053142 Pcdhb17 Q91VD8 Q91VD8_MOUSE uc008eqc.1 uc008eqc.2 uc008eqc.3 molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eqc.1 uc008eqc.2 uc008eqc.3 
ENSMUST00000053862.12 Slc66a1 ENSMUST00000053862.12 solute carrier family 66 member 1, transcript variant 1 (from RefSeq NM_145384.4) ENSMUST00000053862.1 ENSMUST00000053862.10 ENSMUST00000053862.11 ENSMUST00000053862.2 ENSMUST00000053862.3 ENSMUST00000053862.4 ENSMUST00000053862.5 ENSMUST00000053862.6 ENSMUST00000053862.7 ENSMUST00000053862.8 ENSMUST00000053862.9 LAAT1_MOUSE NM_145384 Pqlc2 Q8C4N4 Q8R132 Slc66a1 uc008vma.1 uc008vma.2 uc008vma.3 uc008vma.4 Amino acid transporter that specifically mediates the pH- dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. Lysosome membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C4N4-1; Sequence=Displayed; Name=2; IsoId=Q8C4N4-2; Sequence=VSP_024153; Ubiquitously expressed. The di-leucine motif mediates lysosomal localization. Belongs to the laat-1 family. lysosome lysosomal membrane amino acid transport basic amino acid transmembrane transporter activity arginine transmembrane transporter activity L-lysine transmembrane transporter activity arginine transport lysine transport membrane integral component of membrane integral component of organelle membrane intracellular membrane-bounded organelle amino acid homeostasis L-lysine transmembrane transport arginine transmembrane transport basic amino acid transmembrane transport uc008vma.1 uc008vma.2 uc008vma.3 uc008vma.4 
ENSMUST00000053871.5 Ckap4 ENSMUST00000053871.5 cytoskeleton-associated protein 4 (from RefSeq NM_175451.1) B2RRB4 CKAP4_MOUSE ENSMUST00000053871.1 ENSMUST00000053871.2 ENSMUST00000053871.3 ENSMUST00000053871.4 NM_175451 Q8BMK4 Q8BTK8 Q8R3F2 uc007gkq.1 uc007gkq.2 uc007gkq.3 High-affinity epithelial cell surface receptor for APF. Mediates the anchoring of the endoplasmic reticulum to microtubules. Interacts with REEP5. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Cell membrane ; Single- pass type II membrane protein Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation. Expressed in cardiomyocytes (at protein level). Reversibly palmitoylated. Palmitoylation at Cys-79 by DHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization (By similarity). Increased phosphorylation during mitosis prevents binding to microtubules. Sequence=AAH25522.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH25522.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Vector contamination at the N-terminus.; Evidence=; Sequence=BAC41005.1; Type=Erroneous initiation; Evidence=; cytoplasm endoplasmic reticulum endoplasmic reticulum membrane rough endoplasmic reticulum lipid particle cytosol cytoskeleton plasma membrane biological_process cell surface membrane integral component of membrane nuclear speck cytoplasmic ribonucleoprotein granule perinuclear region of cytoplasm uc007gkq.1 uc007gkq.2 uc007gkq.3 
ENSMUST00000053872.12 Cdc42se1 ENSMUST00000053872.12 CDC42 small effector 1, transcript variant 1 (from RefSeq NM_172395.3) C42S1_MOUSE ENSMUST00000053872.1 ENSMUST00000053872.10 ENSMUST00000053872.11 ENSMUST00000053872.2 ENSMUST00000053872.3 ENSMUST00000053872.4 ENSMUST00000053872.5 ENSMUST00000053872.6 ENSMUST00000053872.7 ENSMUST00000053872.8 ENSMUST00000053872.9 NM_172395 Q8BHL7 uc008qiu.1 uc008qiu.2 uc008qiu.3 uc008qiu.4 Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T- cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity). Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA (By similarity). Cytoplasm, cytoskeleton Cell membrane ; Lipid-anchor The CRIB domain mediates interaction with CDC42. Belongs to the CDC42SE/SPEC family. cytoplasm cytoskeleton plasma membrane cell cortex phagocytosis small GTPase mediated signal transduction regulation of cell shape membrane Rho GTPase binding regulation of Rho protein signal transduction negative regulation of JNK cascade uc008qiu.1 uc008qiu.2 uc008qiu.3 uc008qiu.4 
ENSMUST00000053876.5 G6pd2 ENSMUST00000053876.5 glucose-6-phosphate dehydrogenase 2 (from RefSeq NM_019468.2) ENSMUST00000053876.1 ENSMUST00000053876.2 ENSMUST00000053876.3 ENSMUST00000053876.4 G3UWD6 G3UWD6_MOUSE G6pd2 NM_019468 uc008xly.1 uc008xly.2 uc008xly.3 uc008xly.4 Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5- lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57955, ChEBI:CHEBI:58349, ChEBI:CHEBI:61548; EC=1.1.1.49; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15842; Evidence=; Carbohydrate degradation; pentose phosphate pathway; D- ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Belongs to the glucose-6-phosphate dehydrogenase family. glucose-6-phosphate dehydrogenase activity carbohydrate metabolic process glucose metabolic process pentose-phosphate shunt oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors NADP binding oxidation-reduction process uc008xly.1 uc008xly.2 uc008xly.3 uc008xly.4 
ENSMUST00000053880.13 Grin2b ENSMUST00000053880.13 glutamate receptor, ionotropic, NMDA2B (epsilon 2), transcript variant 1 (from RefSeq NM_008171.4) ENSMUST00000053880.1 ENSMUST00000053880.10 ENSMUST00000053880.11 ENSMUST00000053880.12 ENSMUST00000053880.2 ENSMUST00000053880.3 ENSMUST00000053880.4 ENSMUST00000053880.5 ENSMUST00000053880.6 ENSMUST00000053880.7 ENSMUST00000053880.8 ENSMUST00000053880.9 G3X9V4 G3X9V4_MOUSE Grin2b NM_008171 uc291jtb.1 uc291jtb.2 Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily. ionotropic glutamate receptor activity NMDA glutamate receptor activity ion channel activity plasma membrane integral component of plasma membrane ion transport ligand-gated ion channel activity membrane integral component of membrane glycine binding NMDA selective glutamate receptor complex calcium-mediated signaling glutamate-gated calcium ion channel activity cell junction ionotropic glutamate receptor signaling pathway signaling receptor activity synapse postsynaptic membrane response to ethanol calcium ion transmembrane import into cytosol uc291jtb.1 uc291jtb.2 
ENSMUST00000053896.8 Morc2b ENSMUST00000053896.8 microrchidia 2B, transcript variant 2 (from RefSeq NM_177719.4) B8JK02 ENSMUST00000053896.1 ENSMUST00000053896.2 ENSMUST00000053896.3 ENSMUST00000053896.4 ENSMUST00000053896.5 ENSMUST00000053896.6 ENSMUST00000053896.7 MOR2B_MOUSE Morc2b NM_177719 Q8C5W4 Q8CG24 Tce6 uc008byc.1 uc008byc.2 uc008byc.3 uc008byc.4 Required for chromosomal synapsis and meiotic recombination in males and females. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Interacts with Morc2a. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8C5W4-1; Sequence=Displayed; Name=2 ; IsoId=Q8C5W4-2; Sequence=VSP_052135; Protein is abundant in testes but not detected in other adult tissues examined (at protein level). Detected in germ cells with a distinct developmental-specific expression pattern but not in somatic cells such as Sertoli cells. In juvenile testes, expression is absent prior to postnatal day 12, is detected at a low level at day 12, and increased significantly at day 14 and beyond. In adul testes, expressed in meiotic spermatocytes, abundant in post-meiotic haploid round spermatids, and absent from elongated spermatids. Knockouts are viable and appear to be grossly normal. Mutant males and females show meiotic arrest and sterility. Males have significantly smaller testes than control males. Their testes weigh approximately 70% less than control testes. Their spermatocytes and oocytes exhibit failures in chromosomal synapsis, blockades in meiotic recombination, and increased apoptosis (PubMed:29329290). The ovaries of adult female mutant mice are much smaller than those from heterozygous littermates and are devoid of oocytes (PubMed:29329290). Retrotransposed homolog of Morc2a. nucleotide binding protein binding ATP binding nucleus synapsis gamete generation zinc ion binding hydrolase activity ATPase activity metal ion binding double-strand break repair involved in meiotic recombination uc008byc.1 uc008byc.2 uc008byc.3 uc008byc.4 
ENSMUST00000053906.11 Styxl1 ENSMUST00000053906.11 serine/threonine/tyrosine interacting-like 1, transcript variant 3 (from RefSeq NM_001289555.1) ENSMUST00000053906.1 ENSMUST00000053906.10 ENSMUST00000053906.2 ENSMUST00000053906.3 ENSMUST00000053906.4 ENSMUST00000053906.5 ENSMUST00000053906.6 ENSMUST00000053906.7 ENSMUST00000053906.8 ENSMUST00000053906.9 NM_001289555 Q9DAR2 Q9DAR2_MOUSE Styxl1 uc008zyy.1 uc008zyy.2 uc008zyy.3 uc008zyy.4 pseudophosphatase activity protein phosphatase inhibitor activity mitochondrion protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity positive regulation of neuron projection development dephosphorylation protein phosphatase binding negative regulation of phosphoprotein phosphatase activity regulation of intrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway uc008zyy.1 uc008zyy.2 uc008zyy.3 uc008zyy.4 
ENSMUST00000053913.13 Dgkq ENSMUST00000053913.13 diacylglycerol kinase, theta, transcript variant 1 (from RefSeq NM_199011.2) DGKQ_MOUSE ENSMUST00000053913.1 ENSMUST00000053913.10 ENSMUST00000053913.11 ENSMUST00000053913.12 ENSMUST00000053913.2 ENSMUST00000053913.3 ENSMUST00000053913.4 ENSMUST00000053913.5 ENSMUST00000053913.6 ENSMUST00000053913.7 ENSMUST00000053913.8 ENSMUST00000053913.9 NM_199011 Q3UYE8 Q6P5E8 uc008yot.1 uc008yot.2 uc008yot.3 Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:26748701). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (By similarity). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10273; Evidence=; Reaction=1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:16937, ChEBI:CHEBI:15378, ChEBI:CHEBI:15850, ChEBI:CHEBI:30616, ChEBI:CHEBI:58014, ChEBI:CHEBI:456216; EC=2.7.1.93; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16938; Evidence=; Reaction=1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn- glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:44072, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52595, ChEBI:CHEBI:73332, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44073; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328; Evidence=; Reaction=1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:41672, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:34115, ChEBI:CHEBI:77580, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41673; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2- acetyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:41676, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75936, ChEBI:CHEBI:78385, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41677; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40324; Evidence=; Activated by phosphatidylserine. Lipid metabolism; glycerolipid metabolism. Interacts with RHOA (constitutively activated, GTP-bound); the interaction inhibits DGKQ. Interacts with PRKCE. Interacts with PRKCH. Interacts with PLCB1. Interacts with NR5A1; the interaction requires both LXXLL motifs in DGKQ and is required for full phosphatidic acid- mediated activation of NR5A1. Cytoplasm Cytoplasm, cytosol Cell membrane Synapse Cytoplasm, cytoskeleton Nucleus Nucleus speckle Nucleus matrix Note=Translocates to the plasma membrane in response to steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH. Translocates to the nucleus in response to thrombin stimulation (By similarity). Association with the nuclear matrix is regulated by nerve growth factor (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P5E8-1; Sequence=Displayed; Name=2; IsoId=Q6P5E8-2; Sequence=VSP_037832; Widely expressed in all brain regions, including the cortex and hippocampus with a specific expression in neuronal cells (at protein level). Expression increases through development and peaks at postnatal day 14. The L-X-X-L-L repeats are both required for binding and phosphatidic acid-mediated activation of the nuclear receptor NR5A1. Phosphorylated by PRKCE and PRKCH in vitro. Homozygous knockout mice display no overt phenotype with respect to body size, mating, and lifespan. Belongs to the eukaryotic diacylglycerol kinase family. nucleotide binding NAD+ kinase activity diacylglycerol kinase activity ATP binding nucleus cytoplasm endosome cytosol cytoskeleton plasma membrane regulation of gluconeogenesis regulation of transcription from RNA polymerase II promoter phosphatidic acid biosynthetic process signal transduction activation of transmembrane receptor protein tyrosine kinase activity G-protein coupled receptor signaling pathway protein kinase C-activating G-protein coupled receptor signaling pathway regulation of G-protein coupled receptor protein signaling pathway positive regulation of gene expression negative regulation of gene expression negative regulation of peptidyl-threonine phosphorylation vesicle membrane membrane kinase activity phosphorylation nuclear matrix nuclear speck transferase activity peptidyl-serine phosphorylation kinase binding cAMP-mediated signaling transmembrane receptor protein tyrosine kinase activator activity response to ATP activating transcription factor binding intracellular signal transduction phospholipase binding diacylglycerol metabolic process glycerolipid metabolic process lipid phosphorylation metal ion binding positive regulation of peptidyl-tyrosine phosphorylation response to cAMP thrombin-activated receptor signaling pathway protein kinase C signaling regulation of cholesterol metabolic process presynapse postsynapse glutamatergic synapse regulation of synaptic vesicle endocytosis regulation of TORC1 signaling regulation of cortisol biosynthetic process regulation of progesterone biosynthetic process uc008yot.1 uc008yot.2 uc008yot.3 
ENSMUST00000053917.6 Ccny ENSMUST00000053917.6 cyclin Y (from RefSeq NM_026484.4) CCNY_MOUSE Cfp1 ENSMUST00000053917.1 ENSMUST00000053917.2 ENSMUST00000053917.3 ENSMUST00000053917.4 ENSMUST00000053917.5 NM_026484 Q8BGU5 Q8CI87 Q9CYN5 uc008eai.1 uc008eai.2 uc008eai.3 Positive regulatory subunit of the cyclin-dependent kinase CDK14/PFTK1. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway (By similarity). Recruits CDK16 to the plasma membrane (By similarity). Positive regulatory subunit of the cyclin- dependent kinase CDK16. Found in a complex with CAPRIN2, LRP6 and CDK14 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus (By similarity). Interacts with CDK14 (By similarity). Interacts with CDK16 (PubMed:22184064). Interacts with LRP6 (By similarity). Q8BGU5; Q04735: Cdk16; NbExp=3; IntAct=EBI-772904, EBI-11615670; Cell membrane ; Lipid-anchor ; Cytoplasmic side Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGU5-1; Sequence=Displayed; Name=2; IsoId=Q8BGU5-2; Sequence=VSP_014835; Detected in brain, heart, lung, skeletal muscle, ovary, thymus and testis (at protein level). Ubiquitinated; leading to its degradation. Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination. Belongs to the cyclin family. Cyclin Y subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity G2/M transition of mitotic cell cycle cytoplasmic cyclin-dependent protein kinase holoenzyme complex protein binding nucleus plasma membrane cell cycle membrane Wnt signaling pathway cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding positive regulation of cyclin-dependent protein serine/threonine kinase activity cell division regulation of canonical Wnt signaling pathway uc008eai.1 uc008eai.2 uc008eai.3 
ENSMUST00000053918.9 Pycr3 ENSMUST00000053918.9 pyrroline-5-carboxylate reductase 3 (from RefSeq NM_025412.3) ENSMUST00000053918.1 ENSMUST00000053918.2 ENSMUST00000053918.3 ENSMUST00000053918.4 ENSMUST00000053918.5 ENSMUST00000053918.6 ENSMUST00000053918.7 ENSMUST00000053918.8 NM_025412 P5CR3_MOUSE Pycr3 Pycrl Q8R0P9 Q9D0X2 Q9DCC4 uc007whq.1 uc007whq.2 uc007whq.3 Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. Reaction=L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH; Xref=Rhea:RHEA:14109, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60039; EC=1.5.1.2; Evidence=; Reaction=L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:14105, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60039; EC=1.5.1.2; Evidence=; Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. Homodecamer; composed of 5 homodimers. Cytoplasm Belongs to the pyrroline-5-carboxylate reductase family. Sequence=BAB23252.1; Type=Frameshift; Evidence=; cytidine deaminase activity pyrroline-5-carboxylate reductase activity protein binding cytoplasm cytosol proline biosynthetic process cellular amino acid biosynthetic process cytidine deamination oxidoreductase activity identical protein binding oxidation-reduction process L-proline biosynthetic process uc007whq.1 uc007whq.2 uc007whq.3 
ENSMUST00000053922.12 Vwc2l ENSMUST00000053922.12 von Willebrand factor C domain-containing protein 2-like, transcript variant 1 (from RefSeq NM_177164.4) B7X8X0 E0CXU0 E6Y2G9 ENSMUST00000053922.1 ENSMUST00000053922.10 ENSMUST00000053922.11 ENSMUST00000053922.2 ENSMUST00000053922.3 ENSMUST00000053922.4 ENSMUST00000053922.5 ENSMUST00000053922.6 ENSMUST00000053922.7 ENSMUST00000053922.8 ENSMUST00000053922.9 NM_177164 Q505H4 Q8BNE9 Q8BNU5 VWC2L_MOUSE uc007bjk.1 uc007bjk.2 May play a role in neurogenesis. May promote matrix mineralization (PubMed:22209847), but has been shown to weakly, but significantly inhibit BMP2 and BMP6 activity in a preosteoblastic cell line (PubMed:19852960). Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2L. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Secreted. Synapse Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=F12-a, Vwc2l-1; IsoId=Q505H4-1; Sequence=Displayed; Name=2; IsoId=Q505H4-2; Sequence=VSP_035091; Name=3; IsoId=Q505H4-3; Sequence=VSP_035090, VSP_035092, VSP_035093; Name=4; Synonyms=F12-b, Vwc2l-2; IsoId=Q505H4-4; Sequence=VSP_044591, VSP_044592; Name=5; Synonyms=F12-c, Vwc2l-3; IsoId=Q505H4-5; Sequence=VSP_035091, VSP_044591, VSP_044592; Predominantly expressed in the brain (at protein level). Also detected in bones, including femur and calvaria, heart, lung and kidney. Isoform 5 is predominant in lung and heart, compared to isoforms 1 and 3. Isoform 4 is expressed in femur and calvaria at higher levels than isoforms 1 and 5. Isoforms 1 and 4 are expressed at higher levels than isoform 5 in kidney and brain. From 12.5 dpc to 18.5 dpc, expressed in the developing neural tissues, including several discrete regions in the forebrain, midbrain and hindbrain, as well as in the spinal cord. May be up-regulated in the course of preosteblast differentiation and matrix mineralization. molecular_function extracellular region extracellular space multicellular organism development cell junction negative regulation of BMP signaling pathway AMPA glutamate receptor complex synapse positive regulation of neuron differentiation uc007bjk.1 uc007bjk.2 
ENSMUST00000053926.12 Gm49486 ENSMUST00000053926.12 Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. (from UniProt E9QAC6) AK090155 E9QAC6 E9QAC6_MOUSE ENSMUST00000053926.1 ENSMUST00000053926.10 ENSMUST00000053926.11 ENSMUST00000053926.2 ENSMUST00000053926.3 ENSMUST00000053926.4 ENSMUST00000053926.5 ENSMUST00000053926.6 ENSMUST00000053926.7 ENSMUST00000053926.8 ENSMUST00000053926.9 Gm49486 uc288zos.1 uc288zos.2 Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. Cytoplasm, cytoskeleton Cytoplasm, perinuclear region Membrane ; Lipid-anchor Synapse, synaptosome protein domain specific binding carbohydrate binding uc288zos.1 uc288zos.2 
ENSMUST00000053931.2 Or13c7d ENSMUST00000053931.2 olfactory receptor family 13 subfamily C member 7D (from RefSeq NM_019476.1) ENSMUST00000053931.1 NM_019476 OR37E Olfr159 Or13c7d Q9QZ19 Q9QZ19_MOUSE or37e uc008sra.1 uc008sra.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC134348.1, BC113135.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008sra.1 uc008sra.2 
ENSMUST00000053932.7 Gm28230 ENSMUST00000053932.7 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (from UniProt A0A0A0MQ91) A0A0A0MQ91 A0A0A0MQ91_MOUSE BC063091 ENSMUST00000053932.1 ENSMUST00000053932.2 ENSMUST00000053932.3 ENSMUST00000053932.4 ENSMUST00000053932.5 ENSMUST00000053932.6 Gm28230 uc289xas.1 uc289xas.2 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated anterior/posterior pattern specification activating transcription factor binding positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system morphogenesis uc289xas.1 uc289xas.2 
ENSMUST00000053949.7 Shisa2 ENSMUST00000053949.7 shisa family member 2 (from RefSeq NM_145463.5) ENSMUST00000053949.1 ENSMUST00000053949.2 ENSMUST00000053949.3 ENSMUST00000053949.4 ENSMUST00000053949.5 ENSMUST00000053949.6 NM_145463 Q0NZZ5 Q8BN61 Q8QZV2 SHSA2_MOUSE Shisa Tmem46 uc007uer.1 uc007uer.2 uc007uer.3 uc007uer.4 Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Expressed at 5.5 dpc in the distal visceral endoderm. Expression increases at 6.5 dpc in the most anterior part of the visceral endoderm. At 7.0 dpc expression spreads over the anterior visceral endoderm and occurs in the anterior ectoderm. At 7.75 dpc expressed in the definitive anterior endoderm, anterior mesoderm and anterior neuroectoderm. At 8.25 dpc, when the headfold is formed, expressed in the forebrain, foregut and in segmented somites. At 12.5 dpc, expressed in cerebrum cortex, lateral ganglionic eminences, preoptic area neuroepithelium, hypothalamus, ventral part of otic placode including adjacent mesenchyme, a part of the tongue, endocardial cushion around aortic valve, myotome and muscle primordia. Mice exhibit no defects in head development. Mice are live-born. About one-third of the homozygous mutants were normal and fertile and about two-thirds were dwarf. Reduction in weight gain became apparent at the postnatal third week; about half of the dwarf mice subsequently resumed the weight increase, although they remained dwarf; the other died within a month after birth. Belongs to the shisa family. endoplasmic reticulum endoplasmic reticulum membrane multicellular organism development membrane integral component of membrane negative regulation of Wnt signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway uc007uer.1 uc007uer.2 uc007uer.3 uc007uer.4 
ENSMUST00000053950.10 Lrrc28 ENSMUST00000053950.10 leucine rich repeat containing 28, transcript variant 3 (from RefSeq NR_028143.1) ENSMUST00000053950.1 ENSMUST00000053950.2 ENSMUST00000053950.3 ENSMUST00000053950.4 ENSMUST00000053950.5 ENSMUST00000053950.6 ENSMUST00000053950.7 ENSMUST00000053950.8 ENSMUST00000053950.9 LRC28_MOUSE NR_028143 Q0VGR7 Q3TX51 Q8BK43 uc009hin.1 uc009hin.2 uc009hin.3 uc009hin.4 molecular_function cellular_component uc009hin.1 uc009hin.2 uc009hin.3 uc009hin.4 
ENSMUST00000053956.8 Cypt4 ENSMUST00000053956.8 cysteine-rich perinuclear theca 4 (from RefSeq NM_173412.2) Cypt4 ENSMUST00000053956.1 ENSMUST00000053956.2 ENSMUST00000053956.3 ENSMUST00000053956.4 ENSMUST00000053956.5 ENSMUST00000053956.6 ENSMUST00000053956.7 NM_173412 Q6P925 Q6P925_MOUSE uc009opd.1 uc009opd.2 uc009opd.3 uc009opd.4 molecular_function nucleus biological_process uc009opd.1 uc009opd.2 uc009opd.3 uc009opd.4 
ENSMUST00000053959.7 Ints6 ENSMUST00000053959.7 integrator complex subunit 6 (from RefSeq NM_008715.2) Dbi1 Ddx26 ENSMUST00000053959.1 ENSMUST00000053959.2 ENSMUST00000053959.3 ENSMUST00000053959.4 ENSMUST00000053959.5 ENSMUST00000053959.6 INT6_MOUSE NM_008715 Q3TA02 Q61204 Q6PCM2 Q6PDL7 Q8BQZ7 uc007ugp.1 uc007ugp.2 uc007ugp.3 uc007ugp.4 Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PCM2-1; Sequence=Displayed; Name=2; IsoId=Q6PCM2-2; Sequence=VSP_021461, VSP_021462; Name=3; IsoId=Q6PCM2-3; Sequence=VSP_021459, VSP_021460; Belongs to the Integrator subunit 6 family. Sequence=AAB01338.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence=; nucleus nucleoplasm actin cytoskeleton snRNA processing integrator complex snRNA 3'-end processing uc007ugp.1 uc007ugp.2 uc007ugp.3 uc007ugp.4 
ENSMUST00000053970.4 Gpr119 ENSMUST00000053970.4 G-protein coupled receptor 119 (from RefSeq NM_181751.2) ENSMUST00000053970.1 ENSMUST00000053970.2 ENSMUST00000053970.3 GP119_MOUSE NM_181751 Q2ABS2 Q7TQP3 uc009tcs.1 uc009tcs.2 Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. Cell membrane; Multi-pass membrane protein. Expression restricted to the beta-cells of pancreatic islets. Up-regulated in islets of obese hyperglycemic db/db mice. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway lipid binding membrane integral component of membrane insulin secretion phosphatidylcholine binding receptor complex uc009tcs.1 uc009tcs.2 
ENSMUST00000053981.6 Eola1 ENSMUST00000053981.6 endothelium and lymphocyte associated ASCH domain 1 (from RefSeq NM_026787.2) A2AF50 ENSMUST00000053981.1 ENSMUST00000053981.2 ENSMUST00000053981.3 ENSMUST00000053981.4 ENSMUST00000053981.5 EOLA1_MOUSE Eola1 NM_026787 Q3TDX9 Q9D1F3 uc009tjf.1 uc009tjf.2 uc009tjf.3 May play a role in cell protection during the inflammatory response. In epithelial cells, negatively regulates IL6 production and apoptosis through the regulation of MT2A expression. Interacts with MT2A. Belongs to the EOLA family. molecular_function cellular_component biological_process uc009tjf.1 uc009tjf.2 uc009tjf.3 
ENSMUST00000053986.9 Lingo3 ENSMUST00000053986.9 leucine rich repeat and Ig domain containing 3, transcript variant 2 (from RefSeq NM_001359746.1) E9QK50 ENSMUST00000053986.1 ENSMUST00000053986.2 ENSMUST00000053986.3 ENSMUST00000053986.4 ENSMUST00000053986.5 ENSMUST00000053986.6 ENSMUST00000053986.7 ENSMUST00000053986.8 LIGO3_MOUSE Lrrn6b NM_001359746 Q6GQU6 uc007gey.1 uc007gey.2 uc007gey.3 uc007gey.4 Membrane ; Single-pass type I membrane protein molecular_function extracellular space biological_process membrane integral component of membrane extracellular matrix uc007gey.1 uc007gey.2 uc007gey.3 uc007gey.4 
ENSMUST00000054002.4 Socs3 ENSMUST00000054002.4 suppressor of cytokine signaling 3 (from RefSeq NM_007707.3) Cis3 Cish3 ENSMUST00000054002.1 ENSMUST00000054002.2 ENSMUST00000054002.3 NM_007707 O35718 P97803 Q3U7X5 SOCS3_MOUSE Socs3 uc007moi.1 uc007moi.2 uc007moi.3 uc007moi.4 uc007moi.5 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors (PubMed:10821852, PubMed:12754505, PubMed:9889194). Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling (PubMed:12754505, PubMed:9889194). Suppresses fetal liver erythropoiesis (PubMed:10490101). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (PubMed:12847520). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Protein modification; protein ubiquitination. Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain (By similarity). Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors (PubMed:10882725). Interaction with CSNK1E stabilizes SOCS3 protein (By similarity). Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, elongin BC complex and SOCS3 (By similarity). Interacts with CUL5, RNF7, ELOB and ELOC (By similarity). Interacts with FGFR3 (By similarity). Interacts with INSR (PubMed:10821852). Interacts with BCL10; this interaction may interfere with BCL10-binding with PELI2 (PubMed:15213237). Interacts with NOD2 (via CARD domain); the interaction promotes NOD2 degradation (PubMed:23019338). O35718; Q00560: Il6st; NbExp=6; IntAct=EBI-2659360, EBI-3862992; Low expression in lung, spleen and thymus. Expressed in Th2 but not TH1 cells. In the developing brain, expressed at low levels from 10 dpc stages to young adulthood (P25) with peak levels from 14 dpc to P8. In the cortex, first expressed uniformly in all cells at 14 dpc. Not expressed in the retina. Highly expressed in fetal liver progenitors at 12.5 dpc. By a subset of cytokines including EPO, leptin, LIF, IL-2, IL-3, IL-4, IGF1, growth hormone and prolactin. The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1. phosphotyrosine binding regulation of protein phosphorylation protein binding cytoplasm cytosol phosphatidylinositol 3-kinase complex signal transduction JAK-STAT cascade negative regulation of signal transduction protein ubiquitination intracellular signal transduction regulation of growth negative regulation of tyrosine phosphorylation of STAT protein negative regulation of apoptotic process regulation of phosphatidylinositol 3-kinase activity regulation of cell differentiation positive regulation of cell differentiation negative regulation of JAK-STAT cascade negative regulation of insulin receptor signaling pathway phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity negative regulation of inflammatory response branching involved in labyrinthine layer morphogenesis placenta blood vessel development trophoblast giant cell differentiation spongiotrophoblast differentiation cellular response to leukemia inhibitory factor uc007moi.1 uc007moi.2 uc007moi.3 uc007moi.4 uc007moi.5 
ENSMUST00000054004.2 Or4k52 ENSMUST00000054004.2 olfactory receptor family 4 subfamily K member 52 (from RefSeq NM_146889.2) ENSMUST00000054004.1 NM_146889 Olfr1302 Or4k52 Q8VGE9 Q8VGE9_MOUSE uc008lnz.1 uc008lnz.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008lnz.1 uc008lnz.2 
ENSMUST00000054014.9 Ddx17 ENSMUST00000054014.9 DEAD box helicase 17, transcript variant 1 (from RefSeq NM_199080.2) Ddx17 ENSMUST00000054014.1 ENSMUST00000054014.2 ENSMUST00000054014.3 ENSMUST00000054014.4 ENSMUST00000054014.5 ENSMUST00000054014.6 ENSMUST00000054014.7 ENSMUST00000054014.8 NM_199080 Q3U741 Q3U741_MOUSE uc007wtr.1 uc007wtr.2 uc007wtr.3 This gene encodes the mouse homolog of human DEAD box polypeptide 17. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). RNA helicases of the DEAD-box family are involved in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Belongs to the DEAD box helicase family. nucleotide binding nucleic acid binding helicase activity ATP binding hydrolase activity uc007wtr.1 uc007wtr.2 uc007wtr.3 
ENSMUST00000054018.7 AY074887 ENSMUST00000054018.7 cDNA sequence AY074887 (from RefSeq NM_145229.2) AY074887 ENSMUST00000054018.1 ENSMUST00000054018.2 ENSMUST00000054018.3 ENSMUST00000054018.4 ENSMUST00000054018.5 ENSMUST00000054018.6 Mcpr1 NM_145229 Q8R5F9 Q8R5F9_MOUSE uc009prt.1 uc009prt.2 uc009prt.3 uc009prt.4 molecular_function extracellular space cytoplasm cell cycle arrest negative regulation of cell proliferation membrane integral component of membrane apoptotic signaling pathway uc009prt.1 uc009prt.2 uc009prt.3 uc009prt.4 
ENSMUST00000054034.7 Polq ENSMUST00000054034.7 polymerase (DNA directed), theta, transcript variant 1 (from RefSeq NM_029977.2) Chaos1 DPOLQ_MOUSE ENSMUST00000054034.1 ENSMUST00000054034.2 ENSMUST00000054034.3 ENSMUST00000054034.4 ENSMUST00000054034.5 ENSMUST00000054034.6 NM_029977 Polq Q3UTE0 Q8CGS6 uc007zdm.1 uc007zdm.2 uc007zdm.3 Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non- homologous end-joining (NHEJ) machinery required to repair double- strand breaks in DNA during mitosis (PubMed:21883722, PubMed:25275444, PubMed:25642963, PubMed:25642960, PubMed:29079701, PubMed:31537809). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25275444, PubMed:25642963, PubMed:25642960, PubMed:29079701, PubMed:31537809). MMEJ is required during mitosis to repair persistent double-strand breaks that originate in S-phase (By similarity). Although error-prone, MMEJ protects against chromosomal instability and tumorigenesis (PubMed:30773314). The polymerase acts by binding directly the 2 ends of resected double- strand breaks, allowing microhomologous sequences in the overhangs to form base pairs (By similarity). It then extends each strand from the base-paired region using the opposing overhang as a template (By similarity). Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (By similarity). The polymerase lacks proofreading activity and is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (By similarity). When the ends of a break do not contain terminal microhomology must identify embedded complementary sequences through a scanning step (By similarity). Also shows endonuclease activity, which is required to trim the 3' ends before synthesis can occur, thereby preventing non-paired tails. Also acts as a DNA helicase, promoting dissociation of the replication protein A complex (RPA/RP-A), composed of RPA1, RPA2 and RPA3, from resected double- strand breaks to allow their annealing and subsequent joining by MMEJ (PubMed:29058711). Removal of RPA/RP-A complex proteins prevents RAD51 accumulation at resected ends, thereby inhibiting homology- recombination repair (HR) pathway (PubMed:25642963, PubMed:25642960, PubMed:29058711). Also shows RNA-directed DNA polymerase activity to mediate DNA repair in vitro; however this activity needs additional evidence in vivo (By similarity). May also have lyase activity (By similarity). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (PubMed:16172387, PubMed:16222339, PubMed:16890500, PubMed:17449470). However, POLQ does not play a major role in somatic hypermutation (PubMed:18485835). POLQ- mediated end joining activity is involved in random integration of exogenous DNA hampers (PubMed:28687761). Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence=; Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Homomultimer; forms homodimers and homotetramers. Interacts with RAD51. Interacts with ORC2 and ORC4. Interacts with RHNO1; interaction takes place during mitosis and promotes POLQ recruitment to DNA damage sites. Interacts (when phosphorylated) with TOPBP1 (via BRCT domains 7 and 8); promoting POLQ recruitment to DNA damage sites. Nucleus Chromosome Note=Enriched in chromatin in response to ultaviolet (UV) light. Binds to chromatin during early G1. Recruited to DNA damage sites, such as double-stranded breaks (DSBs), following interaction with TOPBP1 and RHNO1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CGS6-1; Sequence=Displayed; Name=2; IsoId=Q8CGS6-2; Sequence=VSP_057561; The loop 2 region is involved in the binding of the 2 ends of resected double-strand breaks and homomultimerization. Phosphorylated by PLK1; promoting interaction with TOPBP1 and recruitment to DNA damage sites. Mice develop normally, but show elevated frequencies of spontaneous and radiation-induced micronuclei, due to an increased frequency of chromosomal breakage (PubMed:12663541, PubMed:15542845, PubMed:19630521). Mice display a 20% reduction of both A/T and C/G mutations during somatic hypermutation of immunoglobulin genes (PubMed:17449470). Mice lacking both Polh and Polq do not show a further decrease of A/T mutations as compared with mice lacking only Polh (PubMed:17449470). Mice lacking both Fancd2 and Polq die during embryogenesis (PubMed:25642960). Belongs to the DNA polymerase type-A family. nucleotide binding nucleic acid binding DNA binding chromatin binding DNA-directed DNA polymerase activity ATP binding nucleus chromosome cytoplasm DNA replication DNA-dependent DNA replication DNA repair base-excision repair double-strand break repair cellular response to DNA damage stimulus somatic hypermutation of immunoglobulin genes transferase activity nucleotidyltransferase activity single-stranded DNA-dependent ATP-dependent DNA helicase activity DNA duplex unwinding identical protein binding protein homooligomerization 5'-deoxyribose-5-phosphate lyase activity DNA biosynthetic process double-strand break repair via alternative nonhomologous end joining negative regulation of double-strand break repair via homologous recombination uc007zdm.1 uc007zdm.2 uc007zdm.3 
ENSMUST00000054048.10 Mrgpre ENSMUST00000054048.10 MAS-related GPR, member E (from RefSeq NM_175534.3) ENSMUST00000054048.1 ENSMUST00000054048.2 ENSMUST00000054048.3 ENSMUST00000054048.4 ENSMUST00000054048.5 ENSMUST00000054048.6 ENSMUST00000054048.7 ENSMUST00000054048.8 ENSMUST00000054048.9 Ebrt3 MRGRE_MOUSE Mrge NM_175534 Q711I9 Q91ZB7 uc009kpz.1 uc009kpz.2 uc009kpz.3 Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Mas subfamily. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009kpz.1 uc009kpz.2 uc009kpz.3 
ENSMUST00000054050.5 Gimap9 ENSMUST00000054050.5 GTPase, IMAP family member 9, transcript variant 1 (from RefSeq NM_174960.3) ENSMUST00000054050.1 ENSMUST00000054050.2 ENSMUST00000054050.3 ENSMUST00000054050.4 G3X987 GIMA9_MOUSE Ian7 NM_174960 Q4V9U6 Q8CGH1 uc009bvh.1 uc009bvh.2 uc009bvh.3 This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: BB618178.1, BC096680.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Expressed in thymus (in thymocytes), spleen (in splenocytes), lymph node and lung. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. Sequence=AAH38043.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; nucleotide binding GTP binding cytosol biological_process uc009bvh.1 uc009bvh.2 uc009bvh.3 
ENSMUST00000054051.5 Or10s1 ENSMUST00000054051.5 olfactory receptor family 10 subfamily S member 1 (from RefSeq NM_146854.1) ENSMUST00000054051.1 ENSMUST00000054051.2 ENSMUST00000054051.3 ENSMUST00000054051.4 NM_146854 Olfr982 Or10s1 Q8VGB3 Q8VGB3_MOUSE uc009oza.1 uc009oza.2 uc009oza.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC104307.1, BC104306.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oza.1 uc009oza.2 uc009oza.3 
ENSMUST00000054052.15 Zfpm1 ENSMUST00000054052.15 zinc finger protein, multitype 1 (from RefSeq NM_009569.4) ENSMUST00000054052.1 ENSMUST00000054052.10 ENSMUST00000054052.11 ENSMUST00000054052.12 ENSMUST00000054052.13 ENSMUST00000054052.14 ENSMUST00000054052.2 ENSMUST00000054052.3 ENSMUST00000054052.4 ENSMUST00000054052.5 ENSMUST00000054052.6 ENSMUST00000054052.7 ENSMUST00000054052.8 ENSMUST00000054052.9 FOG1_MOUSE Fog Fog1 NM_009569 O35615 uc009nsj.1 uc009nsj.2 uc009nsj.3 Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2. Interacts with the N-terminal zinc-finger of GATA1, GATA2 and GATA3. Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity in erythropoiesis. Interacts with TACC3. O35615; P17679: Gata1; NbExp=7; IntAct=EBI-4394596, EBI-3903251; O35615; Q6ZQ88: Kdm1a; NbExp=2; IntAct=EBI-4394596, EBI-1216284; O35615; Q9JJ11: Tacc3; NbExp=7; IntAct=EBI-4394596, EBI-2553611; O35615; P15976: GATA1; Xeno; NbExp=5; IntAct=EBI-4394596, EBI-3909284; Nucleus Mainly expressed in hematopoietic tissues. Expressed in the spleen, a primary site of hematopoiesis in the adult mouse, as well as in the liver and testis, but not in the heart, brain, lung, kidney, or skeletal muscle. Among hematopoietic cell lines, it is strongly expressed in erythroid and megakaryocytic cell lines. Expressed at low level in several lymphoid and early myeloid cell lines. Not expressed in mast cell and macrophage lines. Expressed in the heart, where it colocalizes with GATA4, GATA5 and GATA6. First expressed in two extraembryonic mesodermal derivatives, the yolk sac and the allantois in 8.5 dpc embryos. Localized to the embryonic red blood cells within the yolk sac blood islands. The CCHC FOG-type zinc fingers 1, 2, 3 and 5 bind directly to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is essential for the interaction with GATA- type zinc fingers. Belongs to the FOG (Friend of GATA) family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding outflow tract morphogenesis atrioventricular valve morphogenesis mitral valve formation tricuspid valve formation nucleic acid binding DNA binding transcription corepressor activity protein binding nucleus transcription factor complex cytoplasm regulation of transcription from RNA polymerase II promoter heart development transcription factor binding regulation of definitive erythrocyte differentiation transcriptional repressor complex erythrocyte differentiation megakaryocyte differentiation platelet formation granulocyte differentiation negative regulation of protein binding regulation of chemokine production embryonic hemopoiesis megakaryocyte development positive regulation of interferon-gamma biosynthetic process negative regulation of interleukin-4 biosynthetic process negative regulation of fat cell differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding homeostasis of number of cells cardiac muscle tissue morphogenesis definitive erythrocyte differentiation primitive erythrocyte differentiation negative regulation of mast cell differentiation ventricular septum morphogenesis atrial septum morphogenesis transcriptional activation by promoter-enhancer looping uc009nsj.1 uc009nsj.2 uc009nsj.3 
ENSMUST00000054072.9 Zfp81 ENSMUST00000054072.9 zinc finger protein 81 (from RefSeq NM_207541.1) B8JJZ7 B8JJZ7_MOUSE ENSMUST00000054072.1 ENSMUST00000054072.2 ENSMUST00000054072.3 ENSMUST00000054072.4 ENSMUST00000054072.5 ENSMUST00000054072.6 ENSMUST00000054072.7 ENSMUST00000054072.8 NM_207541 Zfp81 uc008byi.1 uc008byi.2 uc008byi.3 May be involved in transcriptional regulation. nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc008byi.1 uc008byi.2 uc008byi.3 
ENSMUST00000054080.15 Sinhcaf ENSMUST00000054080.15 SIN3-HDAC complex associated factor, transcript variant 1 (from RefSeq NM_019643.5) ENSMUST00000054080.1 ENSMUST00000054080.10 ENSMUST00000054080.11 ENSMUST00000054080.12 ENSMUST00000054080.13 ENSMUST00000054080.14 ENSMUST00000054080.2 ENSMUST00000054080.3 ENSMUST00000054080.4 ENSMUST00000054080.5 ENSMUST00000054080.6 ENSMUST00000054080.7 ENSMUST00000054080.8 ENSMUST00000054080.9 Fam60a NM_019643 P70361 Q3TLD2 Q8C8M1 SHCAF_MOUSE Tera uc009etr.1 uc009etr.2 uc009etr.3 uc009etr.4 Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (By similarity). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (PubMed:28554894). Component of the Sin3/HDAC corepressor complex at least composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L, HDAC1 (By similarity). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Interacts with SIN3A and OGT (PubMed:28554894). Nucleus Embryonic stem cells (at protein level). Belongs to the SINHCAF family. Sequence=AAB09547.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding nucleus positive regulation of cell proliferation Sin3 complex negative regulation of cell migration negative regulation of cell differentiation uc009etr.1 uc009etr.2 uc009etr.3 uc009etr.4 
ENSMUST00000054095.6 Kctd8 ENSMUST00000054095.6 potassium channel tetramerisation domain containing 8 (from RefSeq NM_175519.5) ENSMUST00000054095.1 ENSMUST00000054095.2 ENSMUST00000054095.3 ENSMUST00000054095.4 ENSMUST00000054095.5 KCTD8_MOUSE NM_175519 Q50H33 Q8BR74 Q8C4C2 Q8C906 Q8C9B0 Q8CAA9 uc008xqj.1 uc008xqj.2 uc008xqj.3 Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization. Interacts as a tetramer with GABRB1 and GABRB2. Presynaptic cell membrane Postsynaptic cell membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q50H33-1; Sequence=Displayed; Name=2; IsoId=Q50H33-2; Sequence=VSP_020761, VSP_020762; molecular_function plasma membrane regulation of G-protein coupled receptor protein signaling pathway membrane cell junction presynaptic membrane receptor complex synapse postsynaptic membrane protein homooligomerization uc008xqj.1 uc008xqj.2 uc008xqj.3 
ENSMUST00000054096.13 Man1c1 ENSMUST00000054096.13 mannosidase, alpha, class 1C, member 1, transcript variant 1 (from RefSeq NM_207237.4) ENSMUST00000054096.1 ENSMUST00000054096.10 ENSMUST00000054096.11 ENSMUST00000054096.12 ENSMUST00000054096.2 ENSMUST00000054096.3 ENSMUST00000054096.4 ENSMUST00000054096.5 ENSMUST00000054096.6 ENSMUST00000054096.7 ENSMUST00000054096.8 ENSMUST00000054096.9 Man1c1 NM_207237 Q6NXK9 Q6NXK9_MOUSE uc012dmw.1 uc012dmw.2 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= Protein modification; protein glycosylation. Belongs to the glycosyl hydrolase 47 family. Golgi membrane catalytic activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity calcium ion binding endoplasmic reticulum Golgi apparatus mannose metabolic process N-glycan processing metabolic process membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds proteoglycan biosynthetic process uc012dmw.1 uc012dmw.2 
ENSMUST00000054098.4 Slc35g1 ENSMUST00000054098.4 solute carrier family 35, member G1 (from RefSeq NM_175507.3) B2RPY9 ENSMUST00000054098.1 ENSMUST00000054098.2 ENSMUST00000054098.3 NM_175507 Q8BY79 S35G1_MOUSE Tmem20 uc008hjn.1 uc008hjn.2 uc008hjn.3 May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell (By similarity). Interacts with STIM1; stimulated by depletion of intracellular calcium. Interacts with ORAI1. Interacts with the plasma membrane calcium-transporting ATPases ATP2B1 and ATP2B4. Interacts with ATP1A1, ATP2A2, KPNB1 and XPO1 (By similarity). Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Belongs to the TMEM20 family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane plasma membrane membrane integral component of membrane regulation of cytosolic calcium ion concentration calcium ion export from cell uc008hjn.1 uc008hjn.2 uc008hjn.3 
ENSMUST00000054099.16 Lhx3 ENSMUST00000054099.16 LIM homeobox protein 3, transcript variant 2 (from RefSeq NM_010711.2) A2ALD9 ENSMUST00000054099.1 ENSMUST00000054099.10 ENSMUST00000054099.11 ENSMUST00000054099.12 ENSMUST00000054099.13 ENSMUST00000054099.14 ENSMUST00000054099.15 ENSMUST00000054099.2 ENSMUST00000054099.3 ENSMUST00000054099.4 ENSMUST00000054099.5 ENSMUST00000054099.6 ENSMUST00000054099.7 ENSMUST00000054099.8 ENSMUST00000054099.9 LHX3_MOUSE Lim-3 Lim3 NM_010711 P50481 Plim Q61800 Q61801 uc008iui.1 uc008iui.2 uc008iui.3 uc008iui.4 Transcription factor (PubMed:18539116, PubMed:10593900, PubMed:12150931). Recognizes and binds to the consensus sequence motif 5'-AATTAATTA-3' in the regulatory elements of target genes, such as glycoprotein hormones alpha chain CGA and visual system homeobox CHX10, positively modulating transcription; transcription can be co-activated by LDB2 (PubMed:18539116, PubMed:10593900, PubMed:9192866). Synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (PubMed:7708713). Required for the establishment of the specialized cells of the pituitary gland and the nervous system (By similarity). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (PubMed:12150931, PubMed:18539116). Interacts with POU1F1 (By similarity). At neuronal promoters, interacts with LDB1, in motor neurons LDB1 is displaced by ISL1 and a ternary complex is formed in which ISL1 contacts both LHX3 and LDB1; allosteric structural changes in the DNA binding domain of LHX3, induced by the ISL1-LHX3 interaction, may explain differences in sequence specificity of the different complexes (PubMed:12150931, PubMed:18583962, PubMed:18539116). Interacts with LDB2 (PubMed:9192866). May interact with CITED2/MRG1 (PubMed:10593900). P50481; P61372: Isl1; NbExp=7; IntAct=EBI-7988290, EBI-7988215; P50481; P70662: Ldb1; NbExp=5; IntAct=EBI-7988290, EBI-6272082; Nucleus Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=LIM3A; IsoId=P50481-1; Sequence=Displayed; Name=LIM3B; IsoId=P50481-2; Sequence=VSP_003108; Mostly expressed in the pituitary anterior and intermediate lobes (PubMed:7811383). It is also expressed in the pineal gland and transiently in the primordia of motor neurons including the spinal cord, pons and medulla oblongata (PubMed:7811383, PubMed:7708713). Expressed throughout pituitary development (PubMed:7811383, PubMed:7708713). Detected at 11 dpc in the primordium of the hypophysis (PubMed:7811383). Following a maximum between 12 dpc and 14 dpc, lower levels persisted into adulthood (PubMed:7811383, PubMed:7708713). Expressed at 11.5 dpc and 12.5 dpc in developing spinal cord, especially in motor neurons (at protein level) (PubMed:18539116). The LIM domain specifically interacts with the POU1F1/Pit-1 POU domain and is required for synergistic interactions with POU1F1, but not for basal transcriptional activation events. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding placenta development DNA binding protein binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated motor neuron axon guidance dorsal/ventral pattern formation spinal cord motor neuron cell fate specification ventral spinal cord interneuron specification medial motor column neuron differentiation spinal cord association neuron differentiation pituitary gland development cell differentiation neuron differentiation lung development negative regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding inner ear development uc008iui.1 uc008iui.2 uc008iui.3 uc008iui.4 
ENSMUST00000054107.6 Kctd21 ENSMUST00000054107.6 potassium channel tetramerisation domain containing 21, transcript variant 2 (from RefSeq NM_001421531.1) B2RTJ2 B2RTJ2_MOUSE ENSMUST00000054107.1 ENSMUST00000054107.2 ENSMUST00000054107.3 ENSMUST00000054107.4 ENSMUST00000054107.5 Kctd21 NM_001421531 uc009ijb.1 uc009ijb.2 uc009ijb.3 Protein modification; protein ubiquitination. ubiquitin-dependent protein catabolic process identical protein binding histone deacetylase binding negative regulation of smoothened signaling pathway protein homooligomerization cullin family protein binding uc009ijb.1 uc009ijb.2 uc009ijb.3 
ENSMUST00000054125.9 Pmel ENSMUST00000054125.9 premelanosome protein (from RefSeq NM_021882.5) D10H12S53E ENSMUST00000054125.1 ENSMUST00000054125.2 ENSMUST00000054125.3 ENSMUST00000054125.4 ENSMUST00000054125.5 ENSMUST00000054125.6 ENSMUST00000054125.7 ENSMUST00000054125.8 NM_021882 PMEL_MOUSE Pmel17 Q60696 Q9CZB2 Si Silv uc007hob.1 uc007hob.2 Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation. May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway. Homodimer; disulfide-linked. Dimerization in the endoplasmic reticulum and early Golgi prevents premature fibril formation. The dimers are resolved to monomers in late- or post-Golgi compartments. Heterooligomer; amyloid-type. Processed amyloidogenic fragments assemble into fibrils that further organize into beta-sheet quaternary amyloid structures. Interacts (via luminal C-terminal fragment) with CD63; this is important for sorting of the luminal fragment in tetraspanin rich microdomains in stage I melanosomes to prevent premature lysosomal degradation. Interacts with APOE; this allows the loading of the luminal fragment on ILVs to induce fibril nucleation. Interacts with MLANA. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Golgi apparatus, cis-Golgi network membrane ; Single-pass type I membrane protein Endosome, multivesicular body Melanosome Extracellular vesicle Secreted Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes predominantly to intralumenal vesicles (ILVs) within multivesicular bodies. Associates with ILVs found within the lumen of premelanosomes and melanosomes and particularly in compartments that serve as precursors to the striated stage II premelanosomes. Sorted to stage I melanosomes following its processing in the ER and cis-Golgi. Transiently expressed at the cell surface before targeting to early melanosomes. Colocalizes with BACE2 in stage I and II melanosomes. Colocalizes with CD63 at exosomes and in intraluminal vesicles within multivesicular endosomes. Expressed in skin melanocytes, choroid melanocytes, and retinal pigmented cells. The core amyloid fragment (CAF) represents the amyloidogenic unit of melanosomal fibrils. The highly O-glycosylated repeat (RPT) domain drives the generation of the fibrillar amyloid sheet structures within melanosomes. The O-glycosylation sites rather than its primary amino acid sequence are conserved across species. The Kringle-like domain (KLD) contains six highly conserved cysteine residues that are critical for dimer formation. N- and O-glycosylated. A small amount of P1/P100 (major form) undergoes glycosylation in ER and Golgi compartments to yield P2/P120 (minor form). The mature P2 form leaves the trans-Golgi network and is mainly targeted to stage I melanosomes via the plasma membrane and clathrin-mediated endocytosis. Stage II melanosomes harbor only Golgi- modified fragments that are derived from M-alpha and that bear sialylated O-linked oligosaccharides. O-glycosylation of the RPT region is a conserved feature likely involved in amyloid sheet separation via electrostatic repulsion. Undergoes multiple proteolytic processing. In a post-Golgi prelysosomal compartment, P2 is cleaved by a furin-like proprotein convertase (PC) into two disulfide-linked subunits: a large lumenal subunit, M-alpha/ME20-S, and an integral membrane subunit, M-beta. Despite cleavage, only a small fraction of M-alpha is secreted, as most M-alpha and M-beta remain associated with each other intracellularly via a disulfide bond. Once targeted to stage I melanosomes, beta- secretase BACE2 cleaves the M-beta fragment to release the amyloidogenic luminal fragment containing M-alpha and a small portion of M-beta N-terminus. M-alpha is further cleaved by metalloproteases and still unknown proteases to yield subfragments that ultimately assemble into amyloid fibrils. The C-terminal fragment of M-beta is processed by the gamma-secretase complex to release a short intracytoplasmic domain. Note=Defects in Silver mutants are the cause of the silver coat color which seems to be due to premature death of pigment cells during the hair cycle. Mutant mice are fertile and have normal development. They display coat color dilution phenotype especially in the brown background. This is associated with abnormal melanogenesis characterized by spherical melanosomes and substantial reduction in eumelanin content in hair. Belongs to the PMEL/NMB family. extracellular region endosome multivesicular body endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus integral component of plasma membrane membrane integral component of membrane melanosome organization multivesicular body membrane melanin biosynthetic process melanosome identical protein binding positive regulation of melanin biosynthetic process uc007hob.1 uc007hob.2 
ENSMUST00000054128.7 Dsg1c ENSMUST00000054128.7 desmoglein 1 gamma (from RefSeq NM_181680.2) DSG1C_MOUSE Dsg6 ENSMUST00000054128.1 ENSMUST00000054128.2 ENSMUST00000054128.3 ENSMUST00000054128.4 ENSMUST00000054128.5 ENSMUST00000054128.6 NM_181680 Q7TQ61 Q7TSF0 uc008eek.1 uc008eek.2 uc008eek.3 This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY192159.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849376 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Cell membrane ; Single-pass type I membrane protein Cell junction, desmosome Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TSF0-1; Sequence=Displayed; Name=2; IsoId=Q7TSF0-2; Sequence=VSP_012903, VSP_012904; Expressed in epidermis, brain, liver, skeletal, muscle and testis. Expressed in embryo at 17 dpc. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. calcium ion binding plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane cell junction desmosome gamma-catenin binding metal ion binding cell-cell adhesion uc008eek.1 uc008eek.2 uc008eek.3 
ENSMUST00000054145.8 Dcaf5 ENSMUST00000054145.8 DDB1 and CUL4 associated factor 5, transcript variant 1 (from RefSeq NM_177267.5) DCAF5_MOUSE ENSMUST00000054145.1 ENSMUST00000054145.2 ENSMUST00000054145.3 ENSMUST00000054145.4 ENSMUST00000054145.5 ENSMUST00000054145.6 ENSMUST00000054145.7 Kiaa1824 NM_177267 Q80T85 Q80VT3 Q80ZW6 Q8BIP8 Q8BVK5 Q8K0Q6 Wdr22 uc007oar.1 uc007oar.2 uc007oar.3 uc007oar.4 Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin- protein ligase complex (CRL4), involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2 (PubMed:30442713). The complex CRL4-DCAF5 is also involved in the ubiquitination of methylated DNMT1 and E2F1 (By similarity). Protein modification; protein ubiquitination. Interacts with DDB1, CUL4A or CUL4B. Interacts with L3MBTL3 (PubMed:30442713). Interacts with SOX2 (PubMed:30442713). Interacts with DNMT1 (By similarity). Interacts with E2F1 (By similarity). Sequence=BAC65843.1; Type=Erroneous initiation; Evidence=; molecular_function mitochondrion biological_process protein ubiquitination Cul4-RING E3 ubiquitin ligase complex uc007oar.1 uc007oar.2 uc007oar.3 uc007oar.4 
ENSMUST00000054146.5 Pfn3 ENSMUST00000054146.5 profilin 3 (from RefSeq NM_029303.2) ENSMUST00000054146.1 ENSMUST00000054146.2 ENSMUST00000054146.3 ENSMUST00000054146.4 NM_029303 PROF3_MOUSE Q9DAD6 uc007qqu.1 uc007qqu.2 Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Slightly reduces actin polymerization. May be involved in spermatogenesis. Interacts with ACTRT3. Q9DAD6; Q8BXF8: Actrt3; NbExp=3; IntAct=EBI-6480328, EBI-6480313; Cytoplasm, cytoskeleton Nucleus Testis specific. Belongs to the profilin family. actin binding protein binding nucleus cytoplasm cytoskeleton lipid binding actin cytoskeleton organization regulation of actin filament polymerization positive regulation of actin filament bundle assembly uc007qqu.1 uc007qqu.2 
ENSMUST00000054147.11 Rhox11 ENSMUST00000054147.11 reproductive homeobox 11 (from RefSeq NM_198598.2) ENSMUST00000054147.1 ENSMUST00000054147.10 ENSMUST00000054147.2 ENSMUST00000054147.3 ENSMUST00000054147.4 ENSMUST00000054147.5 ENSMUST00000054147.6 ENSMUST00000054147.7 ENSMUST00000054147.8 ENSMUST00000054147.9 NM_198598 Q810N8 Q810N8_MOUSE Rhox11 uc009szm.1 uc009szm.2 uc009szm.3 Nucleus RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding nucleus regulation of transcription from RNA polymerase II promoter biological_process uc009szm.1 uc009szm.2 uc009szm.3 
ENSMUST00000054162.4 Defb10 ENSMUST00000054162.4 defensin beta 10 (from RefSeq NM_139225.1) A2A4E8 DFB10_MOUSE ENSMUST00000054162.1 ENSMUST00000054162.2 ENSMUST00000054162.3 NM_139225 Q8R2I8 uc009lcb.1 uc009lcb.2 uc009lcb.3 Has antibacterial activity. Secreted Expressed in both adult and neonate brain, and very weakly in kidneys, epididymis, and testis. Belongs to the beta-defensin family. molecular_function cellular_component extracellular region defense response biological_process defense response to bacterium uc009lcb.1 uc009lcb.2 uc009lcb.3 
ENSMUST00000054173.4 Phospho1 ENSMUST00000054173.4 phosphatase, orphan 1 (from RefSeq NM_153104.3) A2A619 ENSMUST00000054173.1 ENSMUST00000054173.2 ENSMUST00000054173.3 NM_153104 PHOP1_MOUSE Phospho1 Q8R2H9 uc007las.1 uc007las.2 uc007las.3 Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (By similarity). Involved in the generation of inorganic phosphate for bone mineralization (PubMed:17227223). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (PubMed:26457330, PubMed:20684022). Reaction=H2O + phosphoethanolamine = ethanolamine + phosphate; Xref=Rhea:RHEA:16089, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57603, ChEBI:CHEBI:58190; EC=3.1.3.75; Evidence=; Reaction=H2O + phosphocholine = choline + phosphate; Xref=Rhea:RHEA:10492, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:295975; EC=3.1.3.75; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Extracellular vesicle Note=Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. Has a 120-fold higher level of expression in bone compared with a range of soft tissues. Mice display growth plate abnormalities, spontaneous fractures, bowed long bones, osteomalacia and scoliosis in early life (PubMed:20684022). Primary cultures of tibial growth plate chondrocytes and chondrocyte-derived matrix vesicles (MVs) show reduced mineralizing ability, and plasma samples show reduced levels of Alpl/Tnap and elevated plasma diphosphate (inorganic pyrophosphate; PPi) concentrations (PubMed:20684022). Mice lacking both Phospho1 and Alpl/Tnap show a complete absence of skeletal mineralization, leading to perinatal lethality (PubMed:20684022). Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. endochondral ossification dephosphorylation pyrophosphatase activity hydrolase activity phosphatase activity regulation of bone mineralization extracellular matrix bone mineralization involved in bone maturation metal ion binding phosphocholine phosphatase activity phosphoethanolamine phosphatase activity extracellular membrane-bounded organelle uc007las.1 uc007las.2 uc007las.3 
ENSMUST00000054175.7 Pate5 ENSMUST00000054175.7 prostate and testis expressed 5 (from RefSeq NM_029863.1) ENSMUST00000054175.1 ENSMUST00000054175.2 ENSMUST00000054175.3 ENSMUST00000054175.4 ENSMUST00000054175.5 ENSMUST00000054175.6 NM_029863 Pate5 Q9D262 Q9D262_MOUSE uc012gqq.1 uc012gqq.2 molecular_function cellular_component biological_process uc012gqq.1 uc012gqq.2 
ENSMUST00000054197.7 S1pr2 ENSMUST00000054197.7 sphingosine-1-phosphate receptor 2 (from RefSeq NM_010333.4) ENSMUST00000054197.1 ENSMUST00000054197.2 ENSMUST00000054197.3 ENSMUST00000054197.4 ENSMUST00000054197.5 ENSMUST00000054197.6 Edg5 Gpcr13 Lpb2 NM_010333 P52592 Q8C3Q7 Q9R236 S1PR2_MOUSE uc009ojt.1 uc009ojt.2 uc009ojt.3 uc009ojt.4 Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (By similarity). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (By similarity). Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). P52592; Q99P72: Rtn4; NbExp=2; IntAct=EBI-16091339, EBI-3869532; P52592; Q9JK11-1: Rtn4; Xeno; NbExp=3; IntAct=EBI-16091339, EBI-919989; Cell membrane; Multi-pass membrane protein. Most abundant in heart and lung; low, but clearly observed in kidney, liver and thymus; much lower but detectable in brain, testis, stomach and intestine. Not significantly detected in any of the sections of embryonic day (E) 14-18, except in embryonic brain. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor binding sphingosine-1-phosphate signaling pathway G-protein coupled receptor activity integrin binding protein binding plasma membrane signal transduction G-protein coupled receptor signaling pathway positive regulation of peptidyl-threonine phosphorylation membrane integral component of membrane actin cytoskeleton reorganization sphingosine-1-phosphate receptor activity filopodium assembly negative regulation of excitatory postsynaptic potential positive regulation of establishment of endothelial barrier uc009ojt.1 uc009ojt.2 uc009ojt.3 uc009ojt.4 
ENSMUST00000054213.5 Timm8a1 ENSMUST00000054213.5 translocase of inner mitochondrial membrane 8A1 (from RefSeq NM_013898.3) Ddp1 ENSMUST00000054213.1 ENSMUST00000054213.2 ENSMUST00000054213.3 ENSMUST00000054213.4 NM_013898 Q542E5 Q9WVA2 TIM8A_MOUSE Tim8a Timm8a uc009ugd.1 uc009ugd.2 uc009ugd.3 uc009ugd.4 Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8- TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9- TIMM10 70 kDa complex mediates the import of much more proteins (By similarity). Heterohexamer; composed of 3 copies of TIMM8A and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side Present at high level in liver and brain, and at lower level in muscle and heart. In CNS sections, it is predominantly present in the soma and the dendritic portion of the Purkinje cells of the cerebellum, but not in the glial cells. Scattered expression also is also detected in the brain stem, olfactory bulb, substantia nigra, hippocampus and striatum (at protein level). Ubiquitously expressed. The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8A from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). Belongs to the small Tim family. mitochondrion mitochondrial inner membrane mitochondrial intermembrane space protein targeting to mitochondrion zinc ion binding protein transport membrane metal ion binding chaperone-mediated protein transport uc009ugd.1 uc009ugd.2 uc009ugd.3 uc009ugd.4 
ENSMUST00000054220.10 Rpl18a ENSMUST00000054220.10 ribosomal protein L18A (from RefSeq NM_029751.4) ENSMUST00000054220.1 ENSMUST00000054220.2 ENSMUST00000054220.3 ENSMUST00000054220.4 ENSMUST00000054220.5 ENSMUST00000054220.6 ENSMUST00000054220.7 ENSMUST00000054220.8 ENSMUST00000054220.9 NM_029751 P11249 P62717 Q3TSN0 RL18A_MOUSE uc009mca.1 uc009mca.2 uc009mca.3 uc009mca.4 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit (PubMed:36517592). Binds IPO9 with high affinity (By similarity). Cytoplasm Belongs to the eukaryotic ribosomal protein eL20 family. cytoplasmic translation structural constituent of ribosome ribosome translation postsynaptic density cytosolic large ribosomal subunit polysomal ribosome synapse response to antineoplastic agent uc009mca.1 uc009mca.2 uc009mca.3 uc009mca.4 
ENSMUST00000054223.4 Krtap13-21 ENSMUST00000054223.4 RIKEN cDNA 2310057N15 gene (from RefSeq NM_027170.2) 2310057N15Rik ENSMUST00000054223.1 ENSMUST00000054223.2 ENSMUST00000054223.3 NM_027170 Q9D6T8 Q9D6T8_MOUSE uc007zve.1 uc007zve.2 uc007zve.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the PMG family. molecular_function cellular_component biological_process uc007zve.1 uc007zve.2 uc007zve.3 
ENSMUST00000054230.12 Sfmbt1 ENSMUST00000054230.12 Scm-like with four mbt domains 1, transcript variant 1 (from RefSeq NM_001166532.1) ENSMUST00000054230.1 ENSMUST00000054230.10 ENSMUST00000054230.11 ENSMUST00000054230.2 ENSMUST00000054230.3 ENSMUST00000054230.4 ENSMUST00000054230.5 ENSMUST00000054230.6 ENSMUST00000054230.7 ENSMUST00000054230.8 ENSMUST00000054230.9 NM_001166532 Q6NZD3 Q8CFS1 Q9JMD1 SMBT1_MOUSE uc007svq.1 uc007svq.2 uc007svq.3 Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis. Interacts with MYOD1 (By similarity). Component of the SLC (SFMBT1-LSD1-CoREST) corepressor complex, which also contains KDM1A/LSD1 and RCOR1/CoREST. Interacts with KDM1A/LSD1 and RCOR1/CoREST (By similarity). Interacts with MYOD1. Interacts with L3MBTL3 (PubMed:30442713). Nucleus Highly expressed in the testis, low expression is detected in brain, kidney, heart and lung. Highly expressed in germ cells, where it associates with the synaptic regions of meiotic chromosomes in pachytene stage spermatocytes. Highly expressed in undifferentiated myoblasts and expression is reduced during the course of differentiation. The MBT repeats mediate binding to histones tails; however, in contrast to other MBT repeats, does not bind specific histone lysine modifications. The MBT repeats lack the conserved Asp and aromatic cage at conserved positions (By similarity). Sequence=AAH36972.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH66188.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; transcription corepressor activity nucleus nucleoplasm chromatin organization regulation of transcription, DNA-templated spermatogenesis cell differentiation histone binding negative regulation of transcription, DNA-templated negative regulation of muscle organ development uc007svq.1 uc007svq.2 uc007svq.3 
ENSMUST00000054234.10 Nek6 ENSMUST00000054234.10 NIMA (never in mitosis gene a)-related expressed kinase 6, transcript variant 2 (from RefSeq NM_021606.3) ENSMUST00000054234.1 ENSMUST00000054234.2 ENSMUST00000054234.3 ENSMUST00000054234.4 ENSMUST00000054234.5 ENSMUST00000054234.6 ENSMUST00000054234.7 ENSMUST00000054234.8 ENSMUST00000054234.9 NEK6_MOUSE NM_021606 Nek6 Q3TCE9 Q8C6E6 Q9D0E2 Q9DBI8 Q9ES70 uc008jnn.1 uc008jnn.2 uc008jnn.3 uc008jnn.4 Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase- anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, TRIP4, RPS6KB1 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (By similarity). Phosphorylates STAT3 (PubMed:20595392). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.34; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.34; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-108. Interacts with NEK9, predominantly in mitosis. Interacts with KIF11 (via C-terminus). Interacts with APBB1 (via WW domain). Interacts with ANKRA2, ATF4, ARHGAP33, CDC42, CIR1, PRAM1, PTN, PRDX3, PIN1, RAD26L, RBBP6, RPS7, RPS6KB1 and TRIP4 (By similarity). Interacts with STAT3. Cytoplasm. Nucleus. Nucleus speckle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Note=Co- localizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis (By similarity). Highly expressed in the liver. Displays an autoinhibited conformation: Tyr-108 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9 (By similarity). Autophosphorylated. Phosphorylation at Ser-206 is required for its activation. Phosphorylated upon IR or UV-induced DNA damage. Phosphorylated by CHEK1 and CHEK2. Interaction with APBB1 down- regulates phosphorylation at Thr-210 (By similarity). Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. nucleotide binding magnesium ion binding spindle pole transcription corepressor binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleoplasm cytoplasm centrosome microtubule organizing center cytosol cytoskeleton protein phosphorylation apoptotic process cell cycle chromosome segregation kinase activity phosphorylation nuclear speck transferase activity peptidyl-serine phosphorylation kinesin binding protein kinase binding signal transduction by protein phosphorylation regulation of mitotic metaphase/anaphase transition ubiquitin protein ligase binding activation of protein kinase activity macromolecular complex activating transcription factor binding intracellular membrane-bounded organelle protein autophosphorylation metal ion binding cell division uc008jnn.1 uc008jnn.2 uc008jnn.3 uc008jnn.4 
ENSMUST00000054244.7 Dbx2 ENSMUST00000054244.7 developing brain homeobox 2 (from RefSeq NM_207533.2) Dbx2 ENSMUST00000054244.1 ENSMUST00000054244.2 ENSMUST00000054244.3 ENSMUST00000054244.4 ENSMUST00000054244.5 ENSMUST00000054244.6 F8VQH7 F8VQH7_MOUSE NM_207533 uc007xjs.1 uc007xjs.2 uc007xjs.3 Nucleus Belongs to the H2.0 homeobox family. molecular_function DNA binding cellular_component nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding uc007xjs.1 uc007xjs.2 uc007xjs.3 
ENSMUST00000054245.8 Tmem132e ENSMUST00000054245.8 transmembrane protein 132E (from RefSeq NM_001304439.2) A0A0A0MQ93 B7ZN59 ENSMUST00000054245.1 ENSMUST00000054245.2 ENSMUST00000054245.3 ENSMUST00000054245.4 ENSMUST00000054245.5 ENSMUST00000054245.6 ENSMUST00000054245.7 Gm644 NM_001304439 Q5SUX0 Q6IEE6 T132E_MOUSE uc011yaw.1 uc011yaw.2 uc011yaw.3 uc011yaw.4 Required for normal inner ear hair cell function and hearing. Membrane ; Single-pass type I membrane protein Widely expressed, with highest levels in the cochlea. In the cochlea, detected in spiral ganglion, the organ of Corti and stria vascularis. In the organ of Corti, prominently expressed in the outer and inner hair cells, especially at the apical and basal region of the outer hair cell body (at protein level). Belongs to the TMEM132 family. Sequence=CAD80243.1; Type=Miscellaneous discrepancy; Note=Artifactual sequence.; Evidence=; molecular_function biological_process membrane integral component of membrane uc011yaw.1 uc011yaw.2 uc011yaw.3 uc011yaw.4 
ENSMUST00000054251.13 Wdr37 ENSMUST00000054251.13 WD repeat domain 37, transcript variant 2 (from RefSeq NM_001039388.2) ENSMUST00000054251.1 ENSMUST00000054251.10 ENSMUST00000054251.11 ENSMUST00000054251.12 ENSMUST00000054251.2 ENSMUST00000054251.3 ENSMUST00000054251.4 ENSMUST00000054251.5 ENSMUST00000054251.6 ENSMUST00000054251.7 ENSMUST00000054251.8 ENSMUST00000054251.9 Kiaa0982 NM_001039388 Q80Y96 Q8CBE3 Q8CCL2 WDR37_MOUSE uc007pkj.1 uc007pkj.2 uc007pkj.3 uc007pkj.4 Required for normal ER Ca2+ handling in lymphocytes. Together with PACS1, it plays an essential role in stabilizing peripheral lymphocyte populations. Forms homodimers (By similarity). Interacts with PACS1 (PubMed:33630350). Interacts with PACS2 (By similarity). Cytoplasm Nucleus Note=Primarily localized in the cytoplasm with the highest concentration in the perinuclear region and in small clusters at the leading edge of the spreading cells. Mice lacking WDR37 have reduced absolute numbers of circulating T and B lymphocytes. Sequence=BAC98064.1; Type=Erroneous initiation; Evidence=; molecular_function preribosome, large subunit precursor PeBoW complex uc007pkj.1 uc007pkj.2 uc007pkj.3 uc007pkj.4 
ENSMUST00000054260.8 Lipk ENSMUST00000054260.8 lipase, family member K, transcript variant 1 (from RefSeq NM_001205349.1) ENSMUST00000054260.1 ENSMUST00000054260.2 ENSMUST00000054260.3 ENSMUST00000054260.4 ENSMUST00000054260.5 ENSMUST00000054260.6 ENSMUST00000054260.7 LIPK_MOUSE Lipl2 NM_001205349 Q7TML7 Q8BM14 uc012bkr.1 uc012bkr.2 uc012bkr.3 uc012bkr.4 Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity). Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BM14-1; Sequence=Displayed; Name=2; IsoId=Q8BM14-2; Sequence=VSP_025143; Belongs to the AB hydrolase superfamily. Lipase family. extracellular region lipid metabolic process lipid catabolic process hydrolase activity hydrolase activity, acting on ester bonds intracellular membrane-bounded organelle uc012bkr.1 uc012bkr.2 uc012bkr.3 uc012bkr.4 
ENSMUST00000054274.8 Lhfpl2 ENSMUST00000054274.8 lipoma HMGIC fusion partner-like 2 (from RefSeq NM_172589.2) ENSMUST00000054274.1 ENSMUST00000054274.2 ENSMUST00000054274.3 ENSMUST00000054274.4 ENSMUST00000054274.5 ENSMUST00000054274.6 ENSMUST00000054274.7 LHPL2_MOUSE Lhfpl2 NM_172589 Q8BGA2 uc007rlp.1 uc007rlp.2 Plays a role in female and male fertility. Involved in distal reproductive tract development (PubMed:26964900). Membrane ; Multi-pass membrane protein Expressed in the epithelium of the vas deferens (at protein level). Widely expressed (PubMed:26964900). Strongly expressed in heart, spleen, liver, kidney, thymus, testis, brain, lung, intestine, vagina, ovary and uterus (PubMed:26964900). Expressed in follicle cells of the ovary, epithelial cells of the oviduct, both luminal and glandular epithelial cells of the uterus, and epithelial cells of the vagina (PubMed:26964900). Belongs to the LHFP family. molecular_function cellular_component single fertilization membrane integral component of membrane development of primary female sexual characteristics development of primary male sexual characteristics positive regulation of fertilization uc007rlp.1 uc007rlp.2 
ENSMUST00000054287.9 Zbtb39 ENSMUST00000054287.9 zinc finger and BTB domain containing 39 (from RefSeq NM_198035.2) ENSMUST00000054287.1 ENSMUST00000054287.2 ENSMUST00000054287.3 ENSMUST00000054287.4 ENSMUST00000054287.5 ENSMUST00000054287.6 ENSMUST00000054287.7 ENSMUST00000054287.8 NM_198035 Q6PDK0 Q6PDK0_MOUSE Zbtb39 uc007hkl.1 uc007hkl.2 uc007hkl.3 molecular_function nucleic acid binding cellular_component biological_process uc007hkl.1 uc007hkl.2 uc007hkl.3 
ENSMUST00000054294.7 Fzd1 ENSMUST00000054294.7 frizzled class receptor 1 (from RefSeq NM_021457.3) ENSMUST00000054294.1 ENSMUST00000054294.2 ENSMUST00000054294.3 ENSMUST00000054294.4 ENSMUST00000054294.5 ENSMUST00000054294.6 FZD1_MOUSE NM_021457 O08974 O70421 Q7TS82 uc008wig.1 uc008wig.2 uc008wig.3 uc008wig.4 Receptor for Wnt proteins (PubMed:15923619). Activated by WNT7B (PubMed:15923619). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (By similarity). Contradictory results showing activation by WNT7B have been described for mouse (PubMed:15923619). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:15923619). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Interacts with MYOC (By similarity). Interacts with WNT7B (PubMed:15923619). Cell membrane ; Multi-pass membrane protein Expressed in chondrocytes. Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. The FZ domain is involved in binding with Wnt ligands. Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. Belongs to the G-protein coupled receptor Fz/Smo family. Activation by specific Wnt family members may depend on the cells used for the experiment. Contradictory results have been reported for activation by WNT7B in human and mouse. positive regulation of protein phosphorylation membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis transmembrane signaling receptor activity G-protein coupled receptor activity receptor binding frizzled binding plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway cell-cell signaling multicellular organism development cell surface positive regulation of neuron projection development membrane integral component of membrane Wnt signaling pathway Wnt-protein binding PDZ domain binding negative regulation of BMP signaling pathway epithelial cell differentiation autocrine signaling non-canonical Wnt signaling pathway response to drug identical protein binding protein homodimerization activity Wnt-activated receptor activity neuron projection canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated protein heterodimerization activity positive regulation of sequence-specific DNA binding transcription factor activity hard palate development canonical Wnt signaling pathway ventricular septum morphogenesis negative regulation of canonical Wnt signaling pathway planar cell polarity pathway involved in neural tube closure negative regulation of oxidative stress-induced neuron death regulation of presynapse assembly uc008wig.1 uc008wig.2 uc008wig.3 uc008wig.4 
ENSMUST00000054308.13 G2e3 ENSMUST00000054308.13 G2/M-phase specific E3 ubiquitin ligase, transcript variant 1 (from RefSeq NM_001015099.2) E9QK24 ENSMUST00000054308.1 ENSMUST00000054308.10 ENSMUST00000054308.11 ENSMUST00000054308.12 ENSMUST00000054308.2 ENSMUST00000054308.3 ENSMUST00000054308.4 ENSMUST00000054308.5 ENSMUST00000054308.6 ENSMUST00000054308.7 ENSMUST00000054308.8 ENSMUST00000054308.9 G2E3_MOUSE Kiaa1333 NM_001015099 Q5RJY2 Q6ZPT7 Q8BNA4 uc007nml.1 uc007nml.2 uc007nml.3 uc007nml.4 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Required for prevention of apoptotic death in early embryogenesis. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Protein modification; protein ubiquitination. Nucleus, nucleolus Cytoplasm Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage. In the developing embryo, expressed predominantly in the central nervous system and early limb bud. In the adult, highest expression in Purkinje cell bodies and cells lining the ductus deferens. Ubiquitin ligase activity is mediated by two distinct domains, PHD-type zinc fingers 2 and 3. The use of these distinct domains may allow ubiquitination of different targets by each domain. The HECT domain is catalytically inactive and does not contribute to this activity. Embryos die prior to implantation due to massive apoptosis resulting in blastocyst involution. Sequence=BAC98142.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein polyubiquitination blastocyst development ubiquitin-protein transferase activity nucleus nucleolus cytoplasm cytosol apoptotic process multicellular organism development protein ubiquitination transferase activity intracellular membrane-bounded organelle metal ion binding ubiquitin protein ligase activity negative regulation of intrinsic apoptotic signaling pathway uc007nml.1 uc007nml.2 uc007nml.3 uc007nml.4 
ENSMUST00000054310.4 Coa4 ENSMUST00000054310.4 cytochrome c oxidase assembly factor 4 (from RefSeq NM_183270.2) COA4 COA4_MOUSE Chchd8 ENSMUST00000054310.1 ENSMUST00000054310.2 ENSMUST00000054310.3 NM_183270 Q4VA04 Q8BT51 uc009ine.1 uc009ine.2 uc009ine.3 Putative COX assembly factor. Mitochondrion Belongs to the COA4 family. molecular_function mitochondrion mitochondrial intermembrane space mitochondrial respiratory chain complex IV assembly uc009ine.1 uc009ine.2 uc009ine.3 
ENSMUST00000054316.9 Frey1 ENSMUST00000054316.9 Frey regulator of sperm-oocyte fusion 1 (from RefSeq NM_183112.3) A2AHH2 ENSMUST00000054316.1 ENSMUST00000054316.2 ENSMUST00000054316.3 ENSMUST00000054316.4 ENSMUST00000054316.5 ENSMUST00000054316.6 ENSMUST00000054316.7 ENSMUST00000054316.8 FREY_MOUSE Frey Frey1 NM_183112 Q8CF31 uc008kxu.1 uc008kxu.2 uc008kxu.3 Key regulator for male fertility expressed transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly. Upon complete assembly of the IZUMO1 complex, its ER retention is released, facilitating IZUMO1 complex export to the acrosome (PubMed:35960805, PubMed:36050562). Through the interaction with SPPL2C, inhibits its intramembrane protease activity directly accessing the catalytic center of an I-CLiP (PubMed:35960805). Interacts with SPPL2C (via active sites); the interaction stabilizes FREY1 protein and inhibits SPPL2C proteolytic activity (PubMed:35960805). Interacts with IZUMO1; the interaction retains IZUMO1 at the endoplasmic reticulum membrane and coordinates IZUMO1 complex assembly (PubMed:35960805). Endoplasmic reticulum membrane ; Single-pass type II membrane protein Expressed in round spermatids (at protein level). Expressed in round spermatids belonging to stages V to VII/VIII with no visible expression in earlier or later stages. Mutant males are normozoospermic infertile (PubMed:35960805, PubMed:36050562). Mutant males neither have significant differences in testis/body weight ratios nor testicular morphology. They do not show any alteration in basic sperm motility (PubMed:35960805). Sperm from mutant males passes through the zona pellucida, but fails to bind to the oocyte membrane and accumulates in the perivitelline space (PubMed:36050562). FREY1 and SPPL2C double knockout mice are normozoospermic infertile (PubMed:35960805). Sequence=CAM20623.1; Type=Erroneous gene model prediction; Evidence=; molecular_function cellular_component extracellular region biological_process uc008kxu.1 uc008kxu.2 uc008kxu.3 
ENSMUST00000054327.3 Efcab9 ENSMUST00000054327.3 EF-hand calcium binding domain 9 (from RefSeq NM_027031.3) EFCB9_MOUSE ENSMUST00000054327.1 ENSMUST00000054327.2 Efcab9 NM_027031 Q9D5P6 Q9DAM2 uc007ijs.1 uc007ijs.2 uc007ijs.3 uc007ijs.4 Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation (PubMed:34225353, PubMed:31056283). pH-dependent Ca(2+) sensor required to activate the CatSper channel (PubMed:31056283). Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (PubMed:31056283). Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+) (PubMed:31056283). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel (PubMed:31056283). Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG2, CATSPERD, CATSPERE, CATSPERZ, C2CD6/CATSPERT, SLCO6C1, TMEM249, TMEM262 and EFCAB9 (PubMed:34225353). HSPA1 may be an additional auxiliary complex member (By similarity). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (PubMed:34225353). The auxiliary CATSPERB, CATSPERG2, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively (PubMed:34225353). SLCO6C1 interacts with CATSPERE and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex (PubMed:34225353). C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane (Probable). Interacts with CATSPERZ; the interaction is direct, Ca(2+)-dependent and connects EFCAB9 with the CatSper complex (PubMed:31056283). Dissociates from CATSPERZ at elevated pH (PubMed:31056283). Cytoplasm Cell projection, cilium, flagellum Note=Localizes to the principal piece of the sperm tail. Testis-specific. Only expressed after meiosis in testis. Mice are normal but males show severe male subfertility despite normal sperm morphology (PubMed:31056283). Subfertility is caused by defects in sperm motility: spermatozoa have a lower basal level of intracellular calcium and aberrant Ca(2+) homeostasis (PubMed:31056283). calcium ion binding protein binding calmodulin binding cytoplasm cilium spermatogenesis cell differentiation flagellated sperm motility motile cilium cell projection sperm capacitation sperm principal piece uc007ijs.1 uc007ijs.2 uc007ijs.3 uc007ijs.4 
ENSMUST00000054343.15 Akt1s1 ENSMUST00000054343.15 AKT1 substrate 1, transcript variant 2 (from RefSeq NM_026270.4) A2RT52 AKTS1_MOUSE Akt1s1 ENSMUST00000054343.1 ENSMUST00000054343.10 ENSMUST00000054343.11 ENSMUST00000054343.12 ENSMUST00000054343.13 ENSMUST00000054343.14 ENSMUST00000054343.2 ENSMUST00000054343.3 ENSMUST00000054343.4 ENSMUST00000054343.5 ENSMUST00000054343.6 ENSMUST00000054343.7 ENSMUST00000054343.8 ENSMUST00000054343.9 NM_026270 Pras Q9D1F4 uc009grd.1 uc009grd.2 uc009grd.3 Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (By similarity). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (By similarity). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (By similarity). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (By similarity). May also play a role in nerve growth factor-mediated neuroprotection (PubMed:14973226, PubMed:16397181). Associated component of the mechanistic target of rapamycin complex 1 (mTORC1), which contains core MTOR, MLST8 and RPTOR (By similarity). Dissociates from mTORC1 in response to insulin treatment (By similarity). mTORC1 binds to and is inhibited by FKBP12-rapamycin (By similarity). Interacts (via TOS motif) with RPTOR; interaction is direct (By similarity). The phosphorylated form interacts with 14-3-3 proteins (By similarity). Cytoplasm, cytosol Note=Found in the cytosolic fraction of the brain (PubMed:14973226). Colocalizes with cortical neurons following ischemic/reperfusion injury (PubMed:14973226). The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex. Phosphorylated by AKT1; phosphorylation takes place in response to insulin treatment and promotes AKT1S1 interaction with 14-3-3 proteins, leading to relieve its inhibitor activity (By similarity). Phosphorylated by MTOR following mTORC1 activation, inhibiting AKT1S1 inhibitor activity: phosphorylation by MTOR probably serves as a feedback loop that relieves inhibition from AKT1S1 in response to mTORC1 inactivation (By similarity). Phosphorylation at Thr-247 by DYRK3 relieves inhibitory function on mTORC1 (By similarity). nucleus cytoplasm cytosol negative regulation of protein kinase activity Notch signaling pathway TORC1 complex negative regulation of TOR signaling macromolecular complex regulation of apoptotic process regulation of neuron apoptotic process negative regulation of cell size neurotrophin TRK receptor signaling pathway uc009grd.1 uc009grd.2 uc009grd.3 
ENSMUST00000054344.11 Eogt ENSMUST00000054344.11 EGF domain specific O-linked N-acetylglucosamine transferase (from RefSeq NM_175313.5) Aer61 ENSMUST00000054344.1 ENSMUST00000054344.10 ENSMUST00000054344.2 ENSMUST00000054344.3 ENSMUST00000054344.4 ENSMUST00000054344.5 ENSMUST00000054344.6 ENSMUST00000054344.7 ENSMUST00000054344.8 ENSMUST00000054344.9 EOGT_MOUSE Eogt1 NM_175313 Q8BYW9 uc009dai.1 uc009dai.2 uc009dai.3 Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N- acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:48904, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:90838; EC=2.4.1.255; Evidence=; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O- (N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:48908, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:12252, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:90840; EC=2.4.1.255; Evidence=; Endoplasmic reticulum lumen Widely expressed. Expressed in brain, heart, kidney, lung, skeletal muscles and thymus. Highest expression is observed in lung and the lowest in skeletal muscles. Expressed at embryonic day (E) 10.5 in the growing edge of the limb buds. At 11.5 dpc, enriched in the apical ectodermal ridge of the limbs. By 12.5 dpc, expression assumes a digit- condensation pattern in the 4 limbs. Belongs to the glycosyltransferase 61 family. cellular_component endoplasmic reticulum endoplasmic reticulum lumen protein O-linked glycosylation protein N-acetylglucosaminyltransferase activity transferase activity transferase activity, transferring glycosyl groups uc009dai.1 uc009dai.2 uc009dai.3 
ENSMUST00000054351.6 Ndnf ENSMUST00000054351.6 neuron-derived neurotrophic factor (from RefSeq NM_172399.3) ENSMUST00000054351.1 ENSMUST00000054351.2 ENSMUST00000054351.3 ENSMUST00000054351.4 ENSMUST00000054351.5 NDNF_MOUSE NM_172399 Q80VN3 Q8BWV6 Q8C119 uc009cei.1 uc009cei.2 uc009cei.3 Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:31883645). May also act through the regulation of growth factors activity and downstream signaling (By similarity). Also regulates extracellular matrix assembly and cell adhesiveness (PubMed:18757743). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764). Binds heparin and chondroitin sulfate. Secreted Expressed in brain and spinal cord with no expression detected in heart, kidney or liver. Expressed by neurons but not by astrocytes. In the brain, detected in the cerebrum, cerebellum and olfactory bulbs. In the cerebral cortex, highly expressed in Cajal- Retzius cells. Also expressed in hippocampal neurons and in Purkinje and granule cells of the cerebellum (at protein level) (PubMed:20969804). Expressed in neurons along the GnRH migratory route. At 16.5 dpc, specifically expressed in the interfollicular basal cells of the epidermis (at protein level). Detected in the marginal cells and cortical plate of the brain cortex from 16 dpc to P90 with high levels between 16 dpc and P0 and lower levels from P7 to adulthood (at protein level). Up-regulated in endothelial cells of muscles after hind limb ischemic surgery. O-glycosylated; contains heparan sulfate and chondroitin sulfate. N-glycosylated. Knockout mice lacking Ndnf are grossly normal and able to produce viable pups (PubMed:31883645). Absence of Ndnf in 13.5 dpc embryos results in abnormal development of the olfactory system and defective gonadotropin-releasing hormone (GnRH) expressing neurons migration to the hypothalamus (PubMed:31883645). Sequence=BAC33925.1; Type=Frameshift; Evidence=; angiogenesis neuron migration response to ischemia glycosaminoglycan binding extracellular region nitric oxide mediated signal transduction nervous system development heparin binding positive regulation of cell-substrate adhesion positive regulation of neuron projection development peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan extracellular matrix organization extracellular matrix negative regulation of neuron apoptotic process vascular wound healing cellular response to hypoxia negative regulation of endothelial cell apoptotic process uc009cei.1 uc009cei.2 uc009cei.3 
ENSMUST00000054356.16 Mtmr11 ENSMUST00000054356.16 myotubularin related protein 11 (from RefSeq NM_181409.3) ENSMUST00000054356.1 ENSMUST00000054356.10 ENSMUST00000054356.11 ENSMUST00000054356.12 ENSMUST00000054356.13 ENSMUST00000054356.14 ENSMUST00000054356.15 ENSMUST00000054356.2 ENSMUST00000054356.3 ENSMUST00000054356.4 ENSMUST00000054356.5 ENSMUST00000054356.6 ENSMUST00000054356.7 ENSMUST00000054356.8 ENSMUST00000054356.9 MTMRB_MOUSE NM_181409 Q3V1L6 Q80UV0 Q8CG88 uc008qmd.1 uc008qmd.2 uc008qmd.3 uc008qmd.4 Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 380 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity. Sequence=AAH51083.1; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm biological_process uc008qmd.1 uc008qmd.2 uc008qmd.3 uc008qmd.4 
ENSMUST00000054368.7 Gimap1 ENSMUST00000054368.7 GTPase, IMAP family member 1, transcript variant 2 (from RefSeq NM_175860.2) ENSMUST00000054368.1 ENSMUST00000054368.2 ENSMUST00000054368.3 ENSMUST00000054368.4 ENSMUST00000054368.5 ENSMUST00000054368.6 Gimap1 NM_175860 Q3TFI6 Q3TFI6_MOUSE uc009bvp.1 uc009bvp.2 uc009bvp.3 This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. Sequence analysis identified two alternatively spliced variants that encode the same protein. [provided by RefSeq, Jul 2008]. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. GTP binding endoplasmic reticulum membrane integral component of membrane uc009bvp.1 uc009bvp.2 uc009bvp.3 
ENSMUST00000054384.6 Trim56 ENSMUST00000054384.6 tripartite motif-containing 56 (from RefSeq NM_201373.4) A0A0R4J0Q6 A0A0R4J0Q6_MOUSE ENSMUST00000054384.1 ENSMUST00000054384.2 ENSMUST00000054384.3 ENSMUST00000054384.4 ENSMUST00000054384.5 NM_201373 Trim56 uc009abq.1 uc009abq.2 uc009abq.3 uc009abq.4 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Cytoplasm Belongs to the TRIM/RBCC family. zinc ion binding metal ion binding uc009abq.1 uc009abq.2 uc009abq.3 uc009abq.4 
ENSMUST00000054387.8 Rab33b ENSMUST00000054387.8 RAB33B, member RAS oncogene family (from RefSeq NM_016858.2) ENSMUST00000054387.1 ENSMUST00000054387.2 ENSMUST00000054387.3 ENSMUST00000054387.4 ENSMUST00000054387.5 ENSMUST00000054387.6 ENSMUST00000054387.7 NM_016858 Q0PD21 Q0PD21_MOUSE Rab33B Rab33b uc008pea.1 uc008pea.2 uc008pea.3 uc008pea.4 Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding Golgi apparatus Golgi lumen intra-Golgi vesicle-mediated transport Rab protein signal transduction protein localization to Golgi apparatus skeletal system morphogenesis presynapse regulation of Golgi organization negative regulation of constitutive secretory pathway regulation of retrograde vesicle-mediated transport, Golgi to ER uc008pea.1 uc008pea.2 uc008pea.3 uc008pea.4 
ENSMUST00000054395.7 ENSMUSG00000047061 ENSMUST00000054395.7 ENSMUSG00000047061 (from geneSymbol) ENSMUST00000054395.1 ENSMUST00000054395.2 ENSMUST00000054395.3 ENSMUST00000054395.4 ENSMUST00000054395.5 ENSMUST00000054395.6 LF199511 uc288mmx.1 uc288mmx.2 uc288mmx.1 uc288mmx.2 
ENSMUST00000054399.6 Ing1 ENSMUST00000054399.6 inhibitor of growth family, member 1, transcript variant 1 (from RefSeq NM_011919.5) B2RWH0 ENSMUST00000054399.1 ENSMUST00000054399.2 ENSMUST00000054399.3 ENSMUST00000054399.4 ENSMUST00000054399.5 ING1_MOUSE NM_011919 Q9QUP8 Q9QXV3 Q9QXV4 Q9QZX3 uc009kvm.1 uc009kvm.2 uc009kvm.3 uc009kvm.4 Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein. Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53- responsive genes and may act as a tumor suppressor. Interacts with H3K4me3 and to a lesser extent with H3K4me2. Isoform 2 interacts with RSL1D1. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=1b, p37; IsoId=Q9QXV3-1; Sequence=Displayed; Name=2; Synonyms=1a, 1c, p31; IsoId=Q9QXV3-2; Sequence=VSP_050378; In the adult, widely expressed with highest levels in thymus and testis. Expressed throughout the whole embryo at all stages of development examined. At day 10, highest expression is found in the yolk sac while at day 16 and 18, higher levels are found in inner compartments of bone. In the embryo, highest expression of isoform 1 is found at day 11 while highest expression of isoform 2 is found at day 7. The PHD-type zinc finger mediates the binding to H3K4me3. The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5- phosphate (PtdIns(5)P). Belongs to the ING family. nucleus protein import into nucleus cell cycle negative regulation of cell proliferation regulation of cell death methylated histone binding positive regulation of transcription, DNA-templated metal ion binding uc009kvm.1 uc009kvm.2 uc009kvm.3 uc009kvm.4 
ENSMUST00000054414.5 Ccr4 ENSMUST00000054414.5 C-C motif chemokine receptor 4 (from RefSeq NM_009916.2) CCR4_MOUSE Cmkbr4 ENSMUST00000054414.1 ENSMUST00000054414.2 ENSMUST00000054414.3 ENSMUST00000054414.4 NM_009916 P51680 Q14A03 uc009rxo.1 uc009rxo.2 uc009rxo.3 uc009rxo.4 High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival. Cell membrane; Multi-pass membrane protein. Expressed in the thymus, macrophages and T- and B- cells. Low expression at 7.5 dpc and 12.5 dpc in the yolk sac. In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2. Belongs to the G-protein coupled receptor 1 family. neuron migration tolerance induction G-protein coupled receptor activity chemokine receptor activity plasma membrane chemotaxis inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration response to radiation response to bacterium external side of plasma membrane membrane integral component of membrane C-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding neuronal cell body response to antibiotic homeostasis of number of cells positive regulation of positive chemotaxis cell chemotaxis chemokine-mediated signaling pathway uc009rxo.1 uc009rxo.2 uc009rxo.3 uc009rxo.4 
ENSMUST00000054415.12 Zfp668 ENSMUST00000054415.12 zinc finger protein 668, transcript variant 1 (from RefSeq NM_146259.4) ENSMUST00000054415.1 ENSMUST00000054415.10 ENSMUST00000054415.11 ENSMUST00000054415.2 ENSMUST00000054415.3 ENSMUST00000054415.4 ENSMUST00000054415.5 ENSMUST00000054415.6 ENSMUST00000054415.7 ENSMUST00000054415.8 ENSMUST00000054415.9 NM_146259 Q3TEM2 Q3U7Y5 Q8C8B7 Q8K2R5 ZN668_MOUSE Znf668 uc009jxa.1 uc009jxa.2 uc009jxa.3 May be involved in transcriptional regulation. May play a role in DNA repair process. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding cellular_component nucleus metal ion binding uc009jxa.1 uc009jxa.2 uc009jxa.3 
ENSMUST00000054418.12 Rtn4ip1 ENSMUST00000054418.12 reticulon 4 interacting protein 1, transcript variant 2 (from RefSeq NR_152603.1) A0A0R4J0S3 A0A0R4J0S3_MOUSE ENSMUST00000054418.1 ENSMUST00000054418.10 ENSMUST00000054418.11 ENSMUST00000054418.2 ENSMUST00000054418.3 ENSMUST00000054418.4 ENSMUST00000054418.5 ENSMUST00000054418.6 ENSMUST00000054418.7 ENSMUST00000054418.8 ENSMUST00000054418.9 NR_152603 Rtn4ip1 uc007ezp.1 uc007ezp.2 Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. mitochondrion mitochondrial outer membrane zinc ion binding oxidoreductase activity oxidation-reduction process uc007ezp.1 uc007ezp.2 
ENSMUST00000054425.7 H2bl1 ENSMUST00000054425.7 H2B.L histone variant 1 (from RefSeq NM_027064.1) ENSMUST00000054425.1 ENSMUST00000054425.2 ENSMUST00000054425.3 ENSMUST00000054425.4 ENSMUST00000054425.5 ENSMUST00000054425.6 H2BL1_MOUSE H2bl1 NM_027064 Q9D9Z7 SubH2Bv uc011zdm.1 uc011zdm.2 uc011zdm.3 May act as an acrosome-nuclear docking protein in sperm. Cytoplasm Note=Subacrosomal region. Does not localize in nucleus (By similarity). Present in testis (at protein level) (PubMed:11784042, PubMed:17261847). Not detected in other tissues tested (PubMed:17261847). Highly expressed during late spermiogenesis, in condensing spermatids (at protein level). Expression persists in mature spermatozoa (at protein level). Expression is first detected from the round spermatid stage and increases thereafter. Belongs to the histone H2B family. nucleosome DNA binding nucleus nucleoplasm cytoplasm nucleosome assembly protein heterodimerization activity uc011zdm.1 uc011zdm.2 uc011zdm.3 
ENSMUST00000054426.5 Lce1l ENSMUST00000054426.5 late cornified envelope 1L (from RefSeq NM_028628.2) ENSMUST00000054426.1 ENSMUST00000054426.2 ENSMUST00000054426.3 ENSMUST00000054426.4 Lce1l NM_028628 Q9D1G7 Q9D1G7_MOUSE uc008qet.1 uc008qet.2 epidermis development uc008qet.1 uc008qet.2 
ENSMUST00000054434.4 Or5p54 ENSMUST00000054434.4 olfactory receptor family 5 subfamily P member 54 (from RefSeq NM_146495.1) ENSMUST00000054434.1 ENSMUST00000054434.2 ENSMUST00000054434.3 Mor204-20 NM_146495 O5P54_MOUSE Olfr474 Or5p54 Q8VFC9 uc009jbq.1 uc009jbq.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jbq.1 uc009jbq.2 
ENSMUST00000054442.11 N6amt1 ENSMUST00000054442.11 N-6 adenine-specific DNA methyltransferase 1 (putative), transcript variant 1 (from RefSeq NM_026366.2) D3Z6J0 E9PXT7 ENSMUST00000054442.1 ENSMUST00000054442.10 ENSMUST00000054442.2 ENSMUST00000054442.3 ENSMUST00000054442.4 ENSMUST00000054442.5 ENSMUST00000054442.6 ENSMUST00000054442.7 ENSMUST00000054442.8 ENSMUST00000054442.9 Hemk2 Kmt9 N6MT1_MOUSE N6amt1 NM_026366 Pred28 Q4KMV5 Q6PRU9 Q6SKR2 uc007zud.1 uc007zud.2 uc007zud.3 Methyltransferase that can methylate proteins and, to a lower extent, arsenic (PubMed:20606008, PubMed:26797129). Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:26797129). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:20606008, PubMed:26797129). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (By similarity). It however only plays a limited role in arsenic metabolism compared with AS3MT (By similarity). Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10025; Evidence=; Reaction=L-glutaminyl-[protein] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:57452, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:14895, ChEBI:CHEBI:15378, ChEBI:CHEBI:30011, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61891; Evidence=; Reaction=methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:11684, ChEBI:CHEBI:15378, ChEBI:CHEBI:16223, ChEBI:CHEBI:17826, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; Evidence=; Heterodimer; heterodimerization with TRMT112 is required for S-adenosyl-L-methionine-binding. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha , mHemk1 ; IsoId=Q6SKR2-1; Sequence=Displayed; Name=2; Synonyms=Beta , mHemk2 ; IsoId=Q6SKR2-2; Sequence=VSP_059901, VSP_059902; Name=3; IsoId=Q6SKR2-3; Sequence=VSP_059900, VSP_059903; Highly expressed in undifferentiated embryonic stem cells (at protein level) (PubMed:19116772). Also expressed in testis and brain, weakly expressed in differentiated embryonic stem cells and kidney (PubMed:19116772). Not expressed in muscle, heart, placenta, pancreas, lung and stomach (PubMed:19116772). Ubiquitinated, leading to its degradation by the proteasome. Early embryonic lethality (PubMed:20606008). The postimplantation development of mutant embryos is impaired, resulting in degeneration around embryonic day 6.5 (PubMed:20606008). Belongs to the eukaryotic/archaeal PrmC-related family. Sequence=AC140319; Type=Erroneous gene model prediction; Evidence=; Sequence=EDK98331.1; Type=Erroneous gene model prediction; Evidence=; nucleic acid binding protein binding nucleus methyltransferase activity protein methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity site-specific DNA-methyltransferase (adenine-specific) activity toxin metabolic process transferase activity peptidyl-glutamine methylation arsonoacetate metabolic process positive regulation of cell growth methylarsonite methyltransferase activity methylation DNA methylation on adenine macromolecular complex eRF1 methyltransferase complex protein-glutamine N-methyltransferase activity uc007zud.1 uc007zud.2 uc007zud.3 
ENSMUST00000054445.9 Hilpda ENSMUST00000054445.9 hypoxia inducible lipid droplet associated, transcript variant 2 (from RefSeq NM_023516.5) ENSMUST00000054445.1 ENSMUST00000054445.2 ENSMUST00000054445.3 ENSMUST00000054445.4 ENSMUST00000054445.5 ENSMUST00000054445.6 ENSMUST00000054445.7 ENSMUST00000054445.8 HLPDA_MOUSE Hig2 NM_023516 Q3UMU3 Q8VDY1 Q9JLS0 uc009bdd.1 uc009bdd.2 uc009bdd.3 uc009bdd.4 Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation (By similarity). Lipid droplet Secreted Membrane ; Single-pass membrane protein By hypoxia (at protein level). positive regulation of cytokine production receptor binding extracellular region extracellular space nucleoplasm lipid particle positive regulation of cell proliferation cell surface positive regulation of lipid storage membrane integral component of membrane secretory granule autocrine signaling cellular response to hypoxia uc009bdd.1 uc009bdd.2 uc009bdd.3 uc009bdd.4 
ENSMUST00000054450.7 Pdcd2 ENSMUST00000054450.7 programmed cell death 2, transcript variant 10 (from RefSeq NR_182060.1) A0A0R4J0N5 A0A0R4J0N5_MOUSE ENSMUST00000054450.1 ENSMUST00000054450.2 ENSMUST00000054450.3 ENSMUST00000054450.4 ENSMUST00000054450.5 ENSMUST00000054450.6 NR_182060 Pdcd2 uc008aoq.1 uc008aoq.2 nucleus cytoplasm activation of cysteine-type endopeptidase activity involved in apoptotic process programmed cell death enzyme binding positive regulation of apoptotic process metal ion binding regulation of hematopoietic progenitor cell differentiation positive regulation of hematopoietic stem cell proliferation uc008aoq.1 uc008aoq.2 
ENSMUST00000054462.11 Tbc1d8 ENSMUST00000054462.11 TBC1 domain family, member 8, transcript variant 1 (from RefSeq NM_018775.4) ENSMUST00000054462.1 ENSMUST00000054462.10 ENSMUST00000054462.2 ENSMUST00000054462.3 ENSMUST00000054462.4 ENSMUST00000054462.5 ENSMUST00000054462.6 ENSMUST00000054462.7 ENSMUST00000054462.8 ENSMUST00000054462.9 Hblp1 NM_018775 Q3TRZ8 Q3URH3 Q3UU99 Q6P1G8 Q9Z1A9 TBCD8_MOUSE Vrp uc007atg.1 uc007atg.2 uc007atg.3 uc007atg.4 uc007atg.5 uc007atg.6 May act as a GTPase-activating protein for Rab family protein(s). The arginine and glutamine fingers are critical for the GTPase- activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site. Sequence=AAD00658.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH05421.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; GTPase activator activity cell intracellular protein transport Rab GTPase binding activation of GTPase activity uc007atg.1 uc007atg.2 uc007atg.3 uc007atg.4 uc007atg.5 uc007atg.6 
ENSMUST00000054471.10 Rlig1 ENSMUST00000054471.10 RNA 5'-phosphate and 3'-OH ligase 1 (from RefSeq NM_175128.2) ENSMUST00000054471.1 ENSMUST00000054471.2 ENSMUST00000054471.3 ENSMUST00000054471.4 ENSMUST00000054471.5 ENSMUST00000054471.6 ENSMUST00000054471.7 ENSMUST00000054471.8 ENSMUST00000054471.9 NM_175128 Q8BHN7 Q8BHP8 Q8BHV9 RLIG1_MOUSE uc007gxx.1 uc007gxx.2 uc007gxx.3 uc007gxx.4 Functions as an RNA ligase, in vitro. The ligation reaction entails three nucleotidyl transfer steps. In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate. In step 2, the ligase-AMP binds to the nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated intermediate. In step 3, the RNA ligase directs the attack of the 3'-OH on the 5'- phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP. Exhibits selectivity for single-stranded RNA substrates and may not have nick-sealing activity on double-stranded DNA-RNA hybrids. May play a role in maintaining RNA integrity under stress conditions, for example in response to reactive oxygen species (ROS). [RNA ligase 1]: Reaction=ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho- (ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.; EC=6.5.1.3; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BHN7-1; Sequence=Displayed; Name=2; IsoId=Q8BHN7-2; Sequence=VSP_028320, VSP_028321; AMPylates itself (auto-AMPylation). hematopoietic progenitor cell differentiation molecular_function cellular_component uc007gxx.1 uc007gxx.2 uc007gxx.3 uc007gxx.4 
ENSMUST00000054472.4 Bsnd ENSMUST00000054472.4 barttin CLCNK type accessory beta subunit (from RefSeq NM_080458.2) B1AZI5 BSND_MOUSE ENSMUST00000054472.1 ENSMUST00000054472.2 ENSMUST00000054472.3 NM_080458 Q8C740 Q8CHY0 Q8VIM4 uc008tyj.1 uc008tyj.2 uc008tyj.3 uc008tyj.4 Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. Interacts with CLCNK channels. Forms probably heteromers with CLCNKA in the thin ascending limb of Henle and with CLCNKB in the thick ascending limb and more distal segments. Basolateral cell membrane ; Multi-pass membrane protein Note=Staining in membranes of the renal tubule is basolateral. Also detected in basolateral membranes of intercalated cells of the collecting duct, which are known to express CLCNKB as well. Both acid-secreting alpha-intercalated cells and base- secreting beta-intercalated cells express this protein basolaterally, but intervening AQP2-expressing principal cells appear devoid of protein expression. In the inner ear, colocalizes with CLCNK in K(+)- secreting marginal cells of the stria vascularis. The basolateral staining contrasts with the apical localization of the KCNQ1 K(+) channel. Also found in K(+)-secreting vestibular dark cells, where it colocalized in basolateral membranes with CLCNK below apical membranes that expressed KCNQ1. Expression is evident in inner and outer stripes of the outer medulla of the kidney, most probably representing thin limbs of Henle's loop together with some collecting duct coursing through the outer stripe. In situ hybridization in fetal kidney at 18.5 dpc revealed a clear continuity between hybridization signals from the thin limb of Henle's loop and the distal convoluted tubule, suggesting that part of the expression pattern may result from expression in the thick ascending limb of Henle's loop. In addition, strong signals are present in a subset of cortical tubules, representing distal convoluted tubules or cortical collecting duct. Strong expression is also observed in the inner medulla of the kidney. This expression does not extend all the way to the tip of the papilla. Thus this signal most probably represents cells of the thin ascending limbs. In the inner ear, strong and exclusive expression is detected in marginal cells of the stria vascularis. In addition to cochlear signal, expression is observed in dark cells localized at the base of the crista ampullaris of the vestibular organ. Palmitoylation is necessary for activation of plasma membrane- inserted CLC-K/barttin channels. protein binding plasma membrane integral component of plasma membrane chloride transport cellular ion homeostasis sensory perception of sound membrane integral component of membrane basolateral plasma membrane chloride channel regulator activity cellular potassium ion homeostasis cellular chloride ion homeostasis macromolecular complex chloride transmembrane transport chloride channel activity uc008tyj.1 uc008tyj.2 uc008tyj.3 uc008tyj.4 
ENSMUST00000054483.14 Tifa ENSMUST00000054483.14 TRAF-interacting protein with forkhead-associated domain, transcript variant 1 (from RefSeq NM_145133.4) ENSMUST00000054483.1 ENSMUST00000054483.10 ENSMUST00000054483.11 ENSMUST00000054483.12 ENSMUST00000054483.13 ENSMUST00000054483.2 ENSMUST00000054483.3 ENSMUST00000054483.4 ENSMUST00000054483.5 ENSMUST00000054483.6 ENSMUST00000054483.7 ENSMUST00000054483.8 ENSMUST00000054483.9 NM_145133 Q3TLY9 Q793I8 T2bp TIFA_MOUSE Tifa uc008rhm.1 uc008rhm.2 uc008rhm.3 Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (PubMed:11798190). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome- independent mechanism (By similarity). TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP- Heptose), a potent PAMP present in all Gram-negative and some Gram- positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling (By similarity). Homooligomer; homooligomerizes following phosphorylation at Thr-9 (By similarity). Interacts with IRAK1, TRAF2 and TRAF6 (PubMed:11798190). Interacts with TIFAB; binding to TIFAB inhibits TRAF6 activation, possibly by inducing a conformational change in TIFA (By similarity). Interacts with ZCCHC11; binding to ZCCHC11 suppresses the TRAF6-dependent activation of NF-kappa-B (By similarity). Q793I8; Q62406: Irak1; NbExp=2; IntAct=EBI-524817, EBI-448533; Q793I8; P70196: Traf6; NbExp=2; IntAct=EBI-524817, EBI-448028; Cytoplasm Note=Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation. Highly expressed in the spleen and at lower levels in heart, brain, lung, liver, kidney and testes. The FHA domain recognizes and binds phosphorylated Thr-9, promoting homooligomerization and subsequent activation of NF-kappa-B. Phosphorylated at Thr-9 following detection of ADP-D-glycero-beta- D-manno-heptose (ADP-Heptose) by ALPK1. Phosphorylation at Thr-9 by ALPK1 leads to the formation of an intermolecular binding between the FHA domain and phosphorylated Thr-9, promoting TIFA oligomerization and TIFA-mediated NF-kappa-B activation. Belongs to the TIFA family. immune system process cytoplasmic pattern recognition receptor signaling pathway protein binding cytoplasm I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response protein homooligomerization uc008rhm.1 uc008rhm.2 uc008rhm.3 
ENSMUST00000054484.15 Slc4a10 ENSMUST00000054484.15 solute carrier family 4, sodium bicarbonate cotransporter-like, member 10, transcript variant 13 (from RefSeq NM_001362676.2) E9NX85 ENSMUST00000054484.1 ENSMUST00000054484.10 ENSMUST00000054484.11 ENSMUST00000054484.12 ENSMUST00000054484.13 ENSMUST00000054484.14 ENSMUST00000054484.2 ENSMUST00000054484.3 ENSMUST00000054484.4 ENSMUST00000054484.5 ENSMUST00000054484.6 ENSMUST00000054484.7 ENSMUST00000054484.8 ENSMUST00000054484.9 F1DFN1 G3F8Y7 G3F8Y8 G3F8Y9 G3F8Z0 I6VS12 J7K287 Kiaa4136 NM_001362676 Ncbe Q5DTL9 Q8CFS3 Q9EST0 S4A10_MOUSE Slc4a10 uc012bvw.1 uc012bvw.2 uc012bvw.3 uc012bvw.4 Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:20566632). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (PubMed:20566632). Has also been shown to act as a sodium/biocarbonate cotransporter which is not responsible for net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (PubMed:18165320). Reduces the excitability of CA1 pyramidal neurons and modulates short- term synaptic plasticity (PubMed:26136660). Required in retinal cells to maintain normal pH which is necessary for normal vision (PubMed:23056253). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity). [Isoform 2]: Sodium/bicarbonate cotransporter which mediates cotransport of sodium and bicarbonate in association with an efflux of intracellular chloride. Reaction=chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) = chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in); Xref=Rhea:RHEA:72739, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101; Evidence=; [Isoform 2]: Reaction=chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) = chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in); Xref=Rhea:RHEA:72739, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101; Evidence=; [Isoform 2]: Zinc-binding negatively regulates its activity. Basolateral cell membrane ulti-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Cell projection, dendrite ll projection, axon Perikaryon Presynapse stsynapse te=Detected in dendrites and axon terminals of retinal OFF bipolar cells and in axon terminals of ON bipolar cells (PubMed:23056253). In amacrine cells, located in the perikaryon (PubMed:23056253). Also detected in basal and apical dendrites of hippocampal pyramidal cells (PubMed:18165320). Event=Alternative promoter usage, Alternative splicing; Named isoforms=10; Comment=The use of 2 alternative promoters gives rise to isoforms which differ at the N-terminus. In addition, alternative splicing gives rise to further isoform diversity. ; Name=1; Synonyms=NBCn2-B ; IsoId=Q5DTL9-1; Sequence=Displayed; Name=2; Synonyms=NBCn2-A ; IsoId=Q5DTL9-2; Sequence=VSP_019654; Name=3; Synonyms=NBCn2-C ; IsoId=Q5DTL9-3; Sequence=VSP_019654, VSP_060134; Name=4; Synonyms=NBCn2-D ; IsoId=Q5DTL9-4; Sequence=VSP_060134; Name=5; Synonyms=NBCn2-E ; IsoId=Q5DTL9-5; Sequence=VSP_060132, VSP_019654; Name=6; Synonyms=NBCn2-F ; IsoId=Q5DTL9-6; Sequence=VSP_060132; Name=7; Synonyms=NBCn2-G ; IsoId=Q5DTL9-7; Sequence=VSP_060132, VSP_019654, VSP_060134; Name=8; Synonyms=NBCn2-H ; IsoId=Q5DTL9-8; Sequence=VSP_060132, VSP_060134; Name=9; Synonyms=NBCn2-I ; IsoId=Q5DTL9-9; Sequence=VSP_060132, VSP_019654, VSP_060133; Name=10; Synonyms=NBCn2-J ; IsoId=Q5DTL9-10; Sequence=VSP_060132, VSP_060133; In the brain, detected in cerebral cortex, subcortex, cerebellum, hippocampus and medulla (at protein level) (PubMed:20541593, PubMed:18061361, PubMed:21439947, PubMed:24905082). In the cerebrum, expressed at high levels throughout the cortex, at lower levels in striatum and not detectable in the corpus callosum (at protein level) (PubMed:20541593). In the cerebellum, detected at high levels in the molecular layer but at very low levels in the granular layer (at protein level) (PubMed:20541593). In the central nervous system, detected in neurons in the olfactory bulb, cortex and cerebellum (at protein level) (PubMed:18165320). Within the hippocampus, abundantly expressed in CA3 pyramidal cells (at protein level) (PubMed:18165320). Strongly expressed in the retina with high levels in bipolar and amacrine cells (at protein level) (PubMed:23056253). Expressed in the epithelial cells of the choroid plexus (PubMed:14592810, PubMed:15567717). During embryonic development, expressed in neurons of the central nervous system (PubMed:15567717). Also expressed in the peripheral nervous system and in non-neuronal tissues such as the dura and some epithelia including the acid-secreting epithelium of the stomach and the duodenal epithelium (PubMed:15567717). In the embryonic retina, expression is restricted to the neuronal cell layer and the retinal pigment epithelium (PubMed:15567717). [Isoform 2]: Expressed at high levels in brain and at low levels in the pituitary, testis, kidney and ileum. Also expressed in pancreatic islets. In the embryonic central nervous system, detected at 12.5 dpc when expression is observed in all areas of the brain including the cerebellum (PubMed:15567717). In the embryonic cerebral cortex, detected at 14.5 dpc with levels increasing at 18.5 dpc (PubMed:15567717). Repressed in the brain by chronic continuous hypoxia (at protein level). The N-terminal cytoplasmic domain is likely to have a high level of intrinsic disorder. N-glycosylated. Homozygotes are born at the expected Mendelian ratio but most pups die around weaning (PubMed:18165320). When fed soft food from the second week of life onward, most pups catch up with the weight of their wild-type littermates and survive (PubMed:18165320). Adults display normal weight and lifespan, are fertile and do not display major behavioral abnormalities (PubMed:18165320). However, brain ventricle size is drastically reduced and mutants show diminished Na(+)-dependent recovery of pH following acid loading of choroid plexus epithelial cells (PubMed:18165320). Mutants also show reduced excitability of CA3 pyramidal neurson and have increased seizure threshold (PubMed:18165320). Increased excitability of CA1 pyramidal neurons and diminished paired pulse facilitation in the hippocampus (PubMed:26136660). No obvious morphological changes in the retina but mutants display decreased visual acuity and contrast sensitivity in behavioral experiments, smaller scotopic and photopic b-wave amplitudes and longer latencies in electroretinograms, and altered temporal response properties of ganglion cells (PubMed:23056253). Belongs to the anion exchanger (TC 2.A.31) family. Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (PubMed:10993873, PubMed:20566632). Has also been shown to act as a sodium/biocarbonate cotransporter which is not responsible for net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Sequence=BAD90511.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; inorganic anion exchanger activity plasma membrane integral component of plasma membrane protein glycosylation ion transport sodium ion transport anion transport regulation of pH visual perception anion transmembrane transporter activity sodium:bicarbonate symporter activity response to light stimulus post-embryonic development symporter activity antiporter activity anion:anion antiporter activity inorganic anion transport bicarbonate transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane pyramidal neuron development cell junction axon dendrite regulation of cellular pH multicellular organism growth locomotory exploration behavior somatodendritic compartment cell projection neuronal cell body perikaryon axon terminus synapse regulation of short-term neuronal synaptic plasticity brain morphogenesis regulation of intracellular pH apical dendrite basilar dendrite CA3 pyramidal cell dendrite anion transmembrane transport hydrogen ion transmembrane transport uc012bvw.1 uc012bvw.2 uc012bvw.3 uc012bvw.4 
ENSMUST00000054487.10 Ajuba ENSMUST00000054487.10 ajuba LIM protein (from RefSeq NM_010590.5) AJUBA_MOUSE ENSMUST00000054487.1 ENSMUST00000054487.2 ENSMUST00000054487.3 ENSMUST00000054487.4 ENSMUST00000054487.5 ENSMUST00000054487.6 ENSMUST00000054487.7 ENSMUST00000054487.8 ENSMUST00000054487.9 Jub NM_010590 P97472 Q91XC0 uc007twj.1 uc007twj.2 uc007twj.3 uc007twj.4 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Interacts with SLC1A2. Interacts with AURKA; the interaction occurs during mitosis and both proteins are phosphorylated as they form a complex. Interacts with CTNNA1 and with F-actin. Interacts with LATS2; the interaction occurs during mitosis and the complex regulates organization of the spindle apparatus through recruitment of TUBG to the centrosome. Forms a complex with SQSTM1, PRKCZ and TRAF6. Component of the GFI1-AJUBA-HDAC1 repressor complex. Interacts directly (via the LIM domains) with GFI1; the interaction results in the HDAC-dependent corepression of a subset of GFI1 target genes, and is independent of the GFI1 SNAG domain. Interacts with HDAC1, HDAC2 and HDAC3 (By similarity). Interacts with GRB2 and PIP5K1B. Interacts with HDAC1, HDAC2 and HDAC3. Interacts with EIF4E, AGO1, AGO2, DCP2, DDX6, LATS1, LATS2, SAV1, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM domains) with VHL (By similarity). Interacts (via LIM domains) with SNAI1 (via SNAG domain), SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain). Q91XC0; P18911: Rarg; NbExp=2; IntAct=EBI-1565930, EBI-8053650; Q91XC0; Q99684: GFI1; Xeno; NbExp=4; IntAct=EBI-1565930, EBI-949368; Q91XC0; O14744: PRMT5; Xeno; NbExp=4; IntAct=EBI-1565930, EBI-351098; Q91XC0; P10276: RARA; Xeno; NbExp=7; IntAct=EBI-1565930, EBI-413374; Q91XC0; P48443: RXRG; Xeno; NbExp=2; IntAct=EBI-1565930, EBI-712405; Cytoplasm, cytoskeleton. Cell membrane Cell junction Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, P-body Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase (By similarity). Preferentially colocalizes with cadherin-adhesive complexes at sites of cell-cell contacts (By similarity). Colocalizes with GFI1 in the nucleus (By similarity). Expressed in skin, brain and genitourinary organs. Detected in all embryonic germ layers, in the extraembryonic yolk sac blood islands and in the fetal components of the developing placenta. As development progressed, expression is dramatically restricted. LIM region interacts with CTNNA1. The preLIM region binds directly actin filaments (By similarity). LIM-2 and LIM-3 domains mediate the interaction with the N- terminal region of AURKA. The association between LATS2 and AJUBA required the second LIM domain of AJUBA (By similarity). Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA (By similarity). 'Ajuba' means 'curiosity' in Urdu, an Indian dialect. Belongs to the zyxin/ajuba family. negative regulation of transcription from RNA polymerase II promoter P-body response to hypoxia chromatin binding transcription corepressor activity protein binding nucleus nucleoplasm transcription factor complex cytoplasm Golgi apparatus microtubule organizing center cytosol cytoskeleton plasma membrane cell-cell junction adherens junction focal adhesion cytoskeleton organization cell cycle cell adhesion membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules lamellipodium lamellipodium assembly cell junction regulation of cell migration gene silencing by RNA positive regulation of cellular biosynthetic process positive regulation of protein complex assembly negative regulation of kinase activity positive regulation of kinase activity cellular protein localization gene silencing by miRNA wound healing, spreading of epidermal cells negative regulation of hippo signaling regulation of GTPase activity positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAP kinase activity alpha-catenin binding glycerophospholipid biosynthetic process metal ion binding focal adhesion assembly actin filament binding regulation of cellular response to hypoxia positive regulation of gene silencing by miRNA uc007twj.1 uc007twj.2 uc007twj.3 uc007twj.4 
ENSMUST00000054491.6 Sox18 ENSMUST00000054491.6 SRY (sex determining region Y)-box 18 (from RefSeq NM_009236.2) ENSMUST00000054491.1 ENSMUST00000054491.2 ENSMUST00000054491.3 ENSMUST00000054491.4 ENSMUST00000054491.5 NM_009236 P43680 Q3UND6 Q9EQ73 SOX18_MOUSE Sox-18 uc008ona.1 uc008ona.2 uc008ona.3 Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis (PubMed:7651823, PubMed:10742113, PubMed:12748961, PubMed:18931657, PubMed:19429912, PubMed:26939885). Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers (PubMed:18931657, PubMed:26939885). Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells (PubMed:18931657). Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17 (PubMed:16895970). Interaction with MEF2C enhances transcriptional activation (PubMed:11554755). Besides, required for normal hair development (PubMed:11094083, PubMed:12748961). Interacts (via C-terminus) with MEF2C (via MADS box). Nucleus Detected in adult lung, heart and skeletal muscles. Detected at 7.5 and 8.0 dpc in the allantois and blood islands of the yolk sac, and in cells fated to become the endocardium. At 8.5 dpc, detected in the allantois and the nascent vasculature of the yolk sac, the paired dorsal aortae and heart (PubMed:10742113). At 9.5 to 11.0 dpc, detected in endothelial cells of the paired dorsal aortae, in intersomitic vessels and in a network of smaller vessels in head and trunc mesenchyme, and in endothelial cells lining the dorsolateral sector of the cardinal vein (PubMed:10742113, PubMed:18931657). At 10.5 dpc, detected inprecursors of the lymphatic vasculature (PubMed:18931657). At 12.5 dpc, detected in branching vessels and in nascent vibrissae follicles. Detected in vibrissae follicles and pelage follicles at 14.0 dpc (PubMed:10742113). Detected in primary lymph sacs at 13.5 dpc, but is not detected in embryonic or adult lymph vessels (PubMed:18931657). Binds target DNA via the HMG box domain. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Note=Defects in this protein are the cause of the ragged, ragged-like and opossum phenotypes (PubMed:10742113, PubMed:12748961, PubMed:18931657, PubMed:19429912). In all these, missense mutations give rise to a truncated protein that retains DNA-binding ability, but lacks regions required for transcription activation (PubMed:10742113, PubMed:12748961). Homozygous ragged and ragged-like mice are almost completely naked, display prenatal edema and frequently die in utero or shortly after birth. Heterozygous ragged and ragged-like mice are mostly viable, but have a thin, ragged coat (PubMed:12748961). Homozygous opossum mice display no visible phenotype up to 11.5 dpc (PubMed:19429912). From 12.5 dpc onwards, mutant embryos display enlarged surface microvasculature and severe subcutaneaous edema, followed by vascular rupture and hemorrhage beginning at 13.5 dpc (PubMed:18931657, PubMed:19429912). All die shortly after 14.5 dpc (PubMed:12748961, PubMed:18931657, PubMed:19429912). Heterozygous opossum mice are almost completely naked, display prenatal edema and frequently die in utero or shortly after birth (PubMed:12748961). Heterozygous opossum mice display defects in development and patterning of the lymph vessels (PubMed:18931657). Deletion of the DNA-binding and the C-terminal transcription activation domains causes no visible phenotype, excepting slightly darker coat pigmentation and a decreased proportion of auchene and zigzag hairs (PubMed:11094083). The mild phenotype is due to functional redundancy with other Sox genes (PubMed:11094083, PubMed:16895970). The phenotype apparently depends on the genetic context: backcrossing the mutant into a pure C57BL/6 background leads to defective lymphangiogenesis and the same embryonic lethality as observed for opossum mutants (PubMed:18931657). negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis blood vessel development vasculogenesis in utero embryonic development hair follicle development vasculature development lymph vessel development lymphangiogenesis DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated heart development hair cycle process cell differentiation embryonic heart tube development mRNA transcription from RNA polymerase II promoter blood vessel endothelial cell migration sequence-specific DNA binding transcription regulatory region DNA binding nuclear transcription factor complex negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell maturation stem cell fate specification endocardium formation lymphatic endothelial cell differentiation endocardial cell differentiation establishment of endothelial barrier regulation of stem cell proliferation uc008ona.1 uc008ona.2 uc008ona.3 
ENSMUST00000054500.7 C2cd4a ENSMUST00000054500.7 C2 calcium-dependent domain containing 4A (from RefSeq NM_001163143.1) C2cd4a E9Q861 E9Q861_MOUSE ENSMUST00000054500.1 ENSMUST00000054500.2 ENSMUST00000054500.3 ENSMUST00000054500.4 ENSMUST00000054500.5 ENSMUST00000054500.6 NM_001163143 uc012gwe.1 uc012gwe.2 uc012gwe.3 regulation of vascular permeability involved in acute inflammatory response positive regulation of acute inflammatory response nucleus regulation of cell adhesion uc012gwe.1 uc012gwe.2 uc012gwe.3 
ENSMUST00000054514.6 Rtn4rl2 ENSMUST00000054514.6 reticulon 4 receptor-like 2 (from RefSeq NM_199223.1) A2RTJ0 ENSMUST00000054514.1 ENSMUST00000054514.2 ENSMUST00000054514.3 ENSMUST00000054514.4 ENSMUST00000054514.5 NM_199223 Ngrl3 Q3UQ62 Q7M6Z0 R4RL2_MOUSE Rtn4rl2 uc008kjm.1 uc008kjm.2 Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development (PubMed:27339102). Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system (PubMed:22406547). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (PubMed:26335717). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). Interaction with MAG is controversial, and may be indirect (Probable). Interacts with MAG. Does not interact with OMG and RTN4 (By similarity). Cell membrane ; Lipid-anchor, GPI-anchor Membrane raft Cell projection, dendrite Cell projection, axon Perikaryon Note=Localized to the surface of neurons, including axons. Detected close to synapses, but is excluded from synapses. Detected in brain (PubMed:22406547). Detected in hippocampus neurons (at protein level) (PubMed:22325200). At 13.5 dpc, strongly expressed in PNS ganglia and developing heart, and weakly expressed in brain and spinal cord. By postnatal day 1, strongly expressed in dorsal root ganglia and in dorsal and gray matter areas of spinal cord. Expressed in various adult brain structures including the amygdala, cerebral cortex, cerebellum, hippocampus and olfactory bulb. Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; is released both as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein. N-glycosylated. No visible phenotype (PubMed:19367338). Mutant sensory neurons show no decrease of the inhibition of neurite outgrowth by MAG (PubMed:19367338). Compared to wild-type littermates, cultured hippocampus neurons from mutant mice display an increased number of excitatory synapses (PubMed:22325200). Likewise, mice lacking both Rtn4r and Rtn4rl2 display no visible phenotype (PubMed:19367338). Sensory neurons from mice lacking both Rtn4r and Rtn4rl2 show moderately decreased inhibition of neurite outgrowth by MAG (PubMed:19367338). Mice with a triple gene disruption that lack Rtn4r, Rtn4rl1 and Rtn4rl2 have no visible phenotype, are healthy and viable (PubMed:22406547, PubMed:22325200). Mice with a triple gene disruption that lack Rtn4r, Rtn4rl1 and Rtn4rl2 have normal brain size and grossly normal brain anatomy, but display disruption of medial brain structures, including an absence of the fasciola cinereum, corpus callosum agenesis and formation of bilateral Probst bundles indicative of the failure of callosally projecting neurons to extend across the midline (PubMed:27339102). Mice with a triple gene disruption of Rtn4r, Rtn4rl1 and Rtn4rl2 display impaired ability to stay on a rotarod and increased spontaneous locomotion (PubMed:27339102). These mice display an increased number of excitatory synapses in the apical dendritic regions of hippocampus neurons, an increase in the complexity of dendrite structure and increased total dendrite length (PubMed:22325200). One month after birth, mice with a triple gene disruption that lack Rtn4r, Rtn4rl1 and Rtn4rl2 show a significant reduction in the survival of motoneurons (PubMed:26335717). Compared to wild-type or single mutants, cerebellar granule cells from mice lacking Rtn4r, Rtn4rl1 and Rtn4rl2 show decreased myelin-mediated inhibition of neurite outgrowth, an inhibition that is strongly decreased on myelin deficient in Mag, Rtn4 and Omg (PubMed:22406547). Mice lacking both Rtn4r and Rtn4rl1 show increased axon regeneration after injury; the same effect is observed when Rtn4r, Rtn4rl1 and Rtn4rl2 are disrupted (PubMed:22406547). Combined disruption of Rtn4r, Rtn4rl1 and Ptprs further increases axon regeneration after injury (PubMed:22406547). Single gene disruption of Rtn4r, Rtn4rl1 and Rtn4rl2 and combined disruption of Rtn4r and Rtn4rl2 have no effect on axon regeneration (PubMed:22406547). Belongs to the Nogo receptor family. Sequence=BAE25181.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; extracellular space plasma membrane cell surface receptor signaling pathway external side of plasma membrane cell surface negative regulation of neuron projection development membrane corpus callosum development axon dendrite extracellular matrix axon regeneration anchored component of membrane signaling receptor activity cell projection neuron projection perikaryon membrane raft anchored component of plasma membrane uc008kjm.1 uc008kjm.2 
ENSMUST00000054523.6 Iba57 ENSMUST00000054523.6 IBA57 homolog, iron-sulfur cluster assembly, transcript variant 1 (from RefSeq NM_173785.6) CAF17_MOUSE ENSMUST00000054523.1 ENSMUST00000054523.2 ENSMUST00000054523.3 ENSMUST00000054523.4 ENSMUST00000054523.5 NM_173785 Q3T9H1 Q8CAK1 uc007jdd.1 uc007jdd.2 uc007jdd.3 uc007jdd.4 Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Mitochondrion Belongs to the GcvT family. CAF17 subfamily. mitochondrion mitochondrial matrix heme biosynthetic process iron-sulfur cluster assembly transferase activity uc007jdd.1 uc007jdd.2 uc007jdd.3 uc007jdd.4 
ENSMUST00000054532.5 Krtap1-5 ENSMUST00000054532.5 keratin associated protein 1-5 (from RefSeq NM_027157.3) A2A590 A2A590_MOUSE ENSMUST00000054532.1 ENSMUST00000054532.2 ENSMUST00000054532.3 ENSMUST00000054532.4 Krtap1-5 NM_027157 uc007ljc.1 uc007ljc.2 uc007ljc.3 uc007ljc.4 molecular_function cellular_component intermediate filament biological_process keratin filament uc007ljc.1 uc007ljc.2 uc007ljc.3 uc007ljc.4 
ENSMUST00000054534.4 Trap1a ENSMUST00000054534.4 tumor rejection antigen P1A (from RefSeq NM_011635.2) ENSMUST00000054534.1 ENSMUST00000054534.2 ENSMUST00000054534.3 NM_011635 Q3UIV7 Q3UIV7_MOUSE Trap1a uc009uke.1 uc009uke.2 uc009uke.3 membrane integral component of membrane uc009uke.1 uc009uke.2 uc009uke.3 
ENSMUST00000054536.11 Slc66a3 ENSMUST00000054536.11 solute carrier family 66 member 3, transcript variant 1 (from RefSeq NM_172574.2) ENSMUST00000054536.1 ENSMUST00000054536.10 ENSMUST00000054536.2 ENSMUST00000054536.3 ENSMUST00000054536.4 ENSMUST00000054536.5 ENSMUST00000054536.6 ENSMUST00000054536.7 ENSMUST00000054536.8 ENSMUST00000054536.9 NM_172574 Pqlc3 Q8C6U2 Q8QZS7 S66A3_MOUSE uc007nck.1 uc007nck.2 uc007nck.3 Membrane ; Multi-pass membrane protein molecular_function membrane integral component of membrane uc007nck.1 uc007nck.2 uc007nck.3 
ENSMUST00000054538.13 Arhgef39 ENSMUST00000054538.13 Rho guanine nucleotide exchange factor 39 (from RefSeq NM_001013377.3) A2AIN0 ARG39_MOUSE ENSMUST00000054538.1 ENSMUST00000054538.10 ENSMUST00000054538.11 ENSMUST00000054538.12 ENSMUST00000054538.2 ENSMUST00000054538.3 ENSMUST00000054538.4 ENSMUST00000054538.5 ENSMUST00000054538.6 ENSMUST00000054538.7 ENSMUST00000054538.8 ENSMUST00000054538.9 NM_001013377 Q3TQV6 Q66JY6 uc008spz.1 uc008spz.2 uc008spz.3 uc008spz.4 uc008spz.5 Promotes cell proliferation. Cell membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q66JY6-1; Sequence=Displayed; Name=2; IsoId=Q66JY6-2; Sequence=VSP_026287; molecular_function guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity plasma membrane membrane positive regulation of cell migration regulation of Rho protein signal transduction uc008spz.1 uc008spz.2 uc008spz.3 uc008spz.4 uc008spz.5 
ENSMUST00000054541.3 Or13ae2 ENSMUST00000054541.3 olfactory receptor family 13 subfamily AE member 2 (from RefSeq NM_146398.1) ENSMUST00000054541.1 ENSMUST00000054541.2 NM_146398 Olfr1325 Or13ae2 Q8VF43 Q8VF43_MOUSE uc009tph.1 uc009tph.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009tph.1 uc009tph.2 
ENSMUST00000054544.7 Rpl36al ENSMUST00000054544.7 ribosomal protein L36A-like (from RefSeq NM_025589.4) ENSMUST00000054544.1 ENSMUST00000054544.2 ENSMUST00000054544.3 ENSMUST00000054544.4 ENSMUST00000054544.5 ENSMUST00000054544.6 NM_025589 Q5M9P1 Q5M9P1_MOUSE Rpl36a uc007nrs.1 uc007nrs.2 uc007nrs.3 uc007nrs.4 Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL42 family. structural constituent of ribosome endoplasmic reticulum cytosol ribosome plasma membrane translation cytosolic large ribosomal subunit uc007nrs.1 uc007nrs.2 uc007nrs.3 uc007nrs.4 
ENSMUST00000054547.9 Ptpn11 ENSMUST00000054547.9 protein tyrosine phosphatase, non-receptor type 11, transcript variant 1 (from RefSeq NM_011202.3) ENSMUST00000054547.1 ENSMUST00000054547.2 ENSMUST00000054547.3 ENSMUST00000054547.4 ENSMUST00000054547.5 ENSMUST00000054547.6 ENSMUST00000054547.7 ENSMUST00000054547.8 NM_011202 P35235 PTN11_MOUSE Q3TQ84 Q64509 Q6PCL5 uc008zio.1 uc008zio.2 uc008zio.3 uc008zio.4 Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:14967142). Positively regulates MAPK signal transduction pathway (By similarity). Dephosphorylates GAB1, ARHGAP35 and EGFR (By similarity). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (By similarity). Dephosphorylates CDC73 (By similarity). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (PubMed:29644115). Dephosphorylates tyrosine- phosphorylated NEDD9/CAS-L (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Interacts with CD84 and with phosphorylated SIT1 and MZPL1. Interacts with FCRL4, FCRL6 and ANKHD1. Interacts with GAREM1 (tyrosine phosphorylated); the interaction increases MAPK/ERK activity and does not affect the GRB2/SOS complex formation (By similarity). Interacts with PTPNS1 and BCAR3. Interacts with phosphorylated LIME1. Interacts with SHB and INPP5D/SHIP1. Interacts with KIR2DL1; the interaction is enhanced by ARRB2 (By similarity). Interacts with GAB2. Interacts with TERT; the interaction retains TERT in the nucleus. Interacts with PECAM1 and FER. Interacts with EPHA2 (activated); participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream signaling (By similarity). Interacts with MILR1 (tyrosine phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3 (tyrosine-phosphorylated), FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with ROS1; mediates PTPN11 phosphorylation. Interacts with PDGFRA (tyrosine phosphorylated). Interacts with PDGFRB (tyrosine phosphorylated); this interaction increases the PTPN11 phosphatase activity. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with CEACAM1 (via cytoplasmic domain); this interaction depends on the monomer/dimer equilibrium and is phosphorylation-dependent (PubMed:19948503, PubMed:9867848). Interacts with MPIG6B (via ITIM motif) (PubMed:23112346). Interacts with SIGLEC10 (PubMed:23374343). Interacts with Lilrb4a (when tyrosine phosphorylated) (PubMed:10026201). Interacts with SIGLEC10 (By similarity). Interacts with CLEC12B (via ITIM motif); this interaction triggers dephosphorylation and activation of PTPN11. Interacts (via SH2 domains) with NEDD9/CAS-L; the interaction is enhanced when NEDD9/CAS-L is tyrosine phosphorylated (By similarity). P35235; P30999: Ctnnd1; NbExp=3; IntAct=EBI-397236, EBI-529924; P35235; P16879: Fes; NbExp=2; IntAct=EBI-397236, EBI-771815; P35235; Q60631: Grb2; NbExp=3; IntAct=EBI-397236, EBI-1688; P35235; P28776: Ido1; NbExp=5; IntAct=EBI-397236, EBI-4410822; P35235; P97484: Lilrb3; NbExp=2; IntAct=EBI-397236, EBI-15728641; P35235; P15209: Ntrk2; NbExp=2; IntAct=EBI-397236, EBI-309647; P35235; Q8K4V6: Pirb; NbExp=3; IntAct=EBI-397236, EBI-8602514; P35235; P70196: Traf6; NbExp=2; IntAct=EBI-397236, EBI-448028; P35235; P62993: GRB2; Xeno; NbExp=7; IntAct=EBI-397236, EBI-401755; P35235; P10721: KIT; Xeno; NbExp=2; IntAct=EBI-397236, EBI-1379503; Cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P35235-2; Sequence=Displayed; Name=2; IsoId=P35235-1; Sequence=VSP_060440; Highly expressed in brain, heart and kidney. The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing proteins relieves this auto- inhibition, possibly by inducing a conformational change in the enzyme. Phosphorylated on Tyr-542 and Tyr-580 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated by activated PDGFRB (By similarity). Phosphorylated upon activation of the receptor-type kinase PDGFRA. Conditional deletion in limb and head mesenchyme leads to increased cartilage mass and deficient ossification: osteochondroprogenitors become chondrocytes and not osteoblasts caused by inability of PTPN11/SHP2 to mediate tyrosine dephosphorylation of SOX9. Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. DNA damage checkpoint activation of MAPK activity phosphotyrosine binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity SH3/SH2 adaptor activity insulin receptor binding protein binding nucleus cytoplasm mitochondrion cytosol protein dephosphorylation lipid metabolic process triglyceride metabolic process epidermal growth factor receptor signaling pathway integrin-mediated signaling pathway axonogenesis brain development heart development hormone-mediated signaling pathway positive regulation of signal transduction dephosphorylation hydrolase activity phosphatase activity protein kinase binding protein domain specific binding cerebellar cortex formation platelet formation receptor tyrosine kinase binding D1 dopamine receptor binding microvillus organization positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production macromolecular complex abortive mitotic cell cycle regulation of cell adhesion mediated by integrin negative regulation of cell adhesion mediated by integrin multicellular organism growth organ growth peptidyl-tyrosine dephosphorylation megakaryocyte development atrioventricular canal development ERBB signaling pathway hormone metabolic process glucose homeostasis regulation of protein complex assembly phospholipase binding insulin receptor substrate binding cadherin binding positive regulation of mitotic cell cycle positive regulation of glucose import positive regulation of insulin receptor signaling pathway negative regulation of insulin secretion regulation of protein export from nucleus positive regulation of hormone secretion negative regulation of hormone secretion platelet-derived growth factor receptor signaling pathway neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway multicellular organismal reproductive process genitalia development inner ear development homeostasis of number of cells within a tissue positive regulation of peptidyl-tyrosine phosphorylation cell adhesion molecule binding peptide hormone receptor binding negative regulation of cortisol secretion Bergmann glial cell differentiation negative regulation of growth hormone secretion face morphogenesis intestinal epithelial cell migration positive regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus cellular response to epidermal growth factor stimulus protein tyrosine kinase binding uc008zio.1 uc008zio.2 uc008zio.3 uc008zio.4 
ENSMUST00000054551.3 1110032F04Rik ENSMUST00000054551.3 RIKEN cDNA 1110032F04 gene (from RefSeq NM_001167996.2) CC080_MOUSE E9Q0B3 ENSMUST00000054551.1 ENSMUST00000054551.2 NM_001167996 Q8C4H3 uc012cqj.1 uc012cqj.2 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc012cqj.1 uc012cqj.2 
ENSMUST00000054555.10 Zfp41 ENSMUST00000054555.10 zinc finger protein 41, transcript variant 1 (from RefSeq NM_011759.4) ENSMUST00000054555.1 ENSMUST00000054555.2 ENSMUST00000054555.3 ENSMUST00000054555.4 ENSMUST00000054555.5 ENSMUST00000054555.6 ENSMUST00000054555.7 ENSMUST00000054555.8 ENSMUST00000054555.9 NM_011759 Q02526 Q8BSV7 ZFP41_MOUSE Zfp-41 uc007wgy.1 uc007wgy.2 uc007wgy.3 uc007wgy.4 A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis. Nucleus Predominantly in the spermatocytes and spermatids of testes. It is also expressed in the fetus and embryonic stem cells at lower levels. Detected in the newborn testis and peaks at 3 weeks during the first cycle of spermatogenesis. Expressed in the fetus and embryo. Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development spermatogenesis biological_process cell differentiation sequence-specific DNA binding metal ion binding uc007wgy.1 uc007wgy.2 uc007wgy.3 uc007wgy.4 
ENSMUST00000054562.4 Nkx1-2 ENSMUST00000054562.4 NK1 homeobox 2 (from RefSeq NM_009123.2) A4QPC3 ENSMUST00000054562.1 ENSMUST00000054562.2 ENSMUST00000054562.3 NKX12_MOUSE NM_009123 Nkx1.1 P42580 Q9JHF2 Q9JKW5 Q9JKW6 Q9JKW9 Q9JKX0 Q9JKX1 Sax1 uc009kcc.1 uc009kcc.2 uc009kcc.3 May function in cell specification, particularly in the CNS. Interacts with HIPK1, HIPK2, and HIPK3. Nucleus Expression detected in adult brain, testis and spleen. In the testis, expressed in the germ cells of the seminiferous epithelium, in elongating spermatids and in spermatozoa. Expressed throughout the brain with highest levels in regions of the cerebral cortex, hippocampus, diencephalon, pons, medulla and cerebellum. In the embryo, expressed in the developing posterior central nervous system. First seen in the ectoderm lateral to the primitive streak, later it encompasses the neural plate. Starting at day 9.5 pc, expressed in distinct areas of spinal cord, hindbrain, midbrain and forebrain. In the embryo, expressed at highest levels at day 10 with levels decreasing during further development. Phosphorylated by HIPK2 in vitro. Belongs to the NK-1 homeobox family. Sequence=AAF43670.1; Type=Erroneous gene model prediction; Evidence=; Sequence=AAF43672.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=AAF43674.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated multicellular organism development cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc009kcc.1 uc009kcc.2 uc009kcc.3 
ENSMUST00000054588.15 Col9a1 ENSMUST00000054588.15 collagen, type IX, alpha 1, transcript variant 1 (from RefSeq NM_007740.3) Col9a1 ENSMUST00000054588.1 ENSMUST00000054588.10 ENSMUST00000054588.11 ENSMUST00000054588.12 ENSMUST00000054588.13 ENSMUST00000054588.14 ENSMUST00000054588.2 ENSMUST00000054588.3 ENSMUST00000054588.4 ENSMUST00000054588.5 ENSMUST00000054588.6 ENSMUST00000054588.7 ENSMUST00000054588.8 ENSMUST00000054588.9 G3X995 G3X995_MOUSE NM_007740 uc007amo.1 uc007amo.2 uc007amo.3 uc007amo.4 collagen trimer collagen type IX trimer uc007amo.1 uc007amo.2 uc007amo.3 uc007amo.4 
ENSMUST00000054591.10 Thnsl1 ENSMUST00000054591.10 threonine synthase-like 1 (bacterial), transcript variant 1 (from RefSeq NM_177588.2) ENSMUST00000054591.1 ENSMUST00000054591.2 ENSMUST00000054591.3 ENSMUST00000054591.4 ENSMUST00000054591.5 ENSMUST00000054591.6 ENSMUST00000054591.7 ENSMUST00000054591.8 ENSMUST00000054591.9 NM_177588 Q8BH55 THNS1_MOUSE uc008inb.1 uc008inb.2 Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Belongs to the threonine synthase family. uc008inb.1 uc008inb.2 
ENSMUST00000054594.15 Syne4 ENSMUST00000054594.15 spectrin repeat containing, nuclear envelope family member 4, transcript variant 1 (from RefSeq NM_153577.3) ENSMUST00000054594.1 ENSMUST00000054594.10 ENSMUST00000054594.11 ENSMUST00000054594.12 ENSMUST00000054594.13 ENSMUST00000054594.14 ENSMUST00000054594.2 ENSMUST00000054594.3 ENSMUST00000054594.4 ENSMUST00000054594.5 ENSMUST00000054594.6 ENSMUST00000054594.7 ENSMUST00000054594.8 ENSMUST00000054594.9 NM_153577 Q6PH99 Q8CII8 Q99J42 SYNE4_MOUSE uc009gec.1 uc009gec.2 uc009gec.3 As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology, by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus. Core component of LINC complexes which are composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain- containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents can give rise to specific assemblies. Probably part of a SUN1-containing LINC complex. Interacts with kinesins KIF5B and KLC1. Q8CII8; P33176: KIF5B; Xeno; NbExp=2; IntAct=EBI-15752280, EBI-355878; Nucleus outer membrane ; Single-pass type IV membrane protein te=Localization at the nucleus outer membrane location requires the presence of SUN1. Expressed in secretory epithelial cells, such as those found in exocrine pancreas, bulbourethral gland, mammary gland and salivary gland (at protein level). Also expressed in the cochlea, where it is restricted primarily to the 3 rows of outer hair cells and 1 row of inner hair cells (at protein level). Not detected in other cells of the cochlea, including Deiter's cells and pillar cells, nor in liver and kidney (at protein level). In the cochlea, low expression at P0 and P15, then rises significantly by P30 and remains steady. In the HC11 cell line model, up-regulated during differentiation of mammary cells into milk- secreting cells (at protein level). The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains. The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces. Mice are born at the expected Mendelian rate and look overtly normal. In the cochlea, outer hair cells form, but appear to degenerate as hearing matures. Inner hair cells remain intact. Hearing loss is already detected at P15 and progresses at all frequencies by P60. Belongs to the nesprin family. protein binding nucleus nuclear envelope nuclear outer membrane membrane integral component of membrane integral component of nuclear outer membrane LINC complex establishment of epithelial cell apical/basal polarity uc009gec.1 uc009gec.2 uc009gec.3 
ENSMUST00000054598.12 Ablim2 ENSMUST00000054598.12 actin-binding LIM protein 2, transcript variant 3 (from RefSeq NM_177678.7) ABLM2_MOUSE B2RUF8 ENSMUST00000054598.1 ENSMUST00000054598.10 ENSMUST00000054598.11 ENSMUST00000054598.2 ENSMUST00000054598.3 ENSMUST00000054598.4 ENSMUST00000054598.5 ENSMUST00000054598.6 ENSMUST00000054598.7 ENSMUST00000054598.8 ENSMUST00000054598.9 NM_177678 Q6H8P8 Q80WK6 Q8BL65 Q8BUT1 Q8BXI7 uc008xeg.1 uc008xeg.2 uc008xeg.3 uc008xeg.4 May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. Interacts with F-actin and ABRA. Cytoplasm Note=In skeletal muscle, sarcomeric or cosarcomeric localization. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8BL65-1; Sequence=Displayed; Name=2; IsoId=Q8BL65-2; Sequence=VSP_012122; Name=3; IsoId=Q8BL65-3; Sequence=VSP_012121, VSP_012122; Name=4; IsoId=Q8BL65-4; Sequence=VSP_012120, VSP_012121, VSP_012122; Name=5; IsoId=Q8BL65-5; Sequence=VSP_012121, VSP_012123, VSP_012124; Expressed in brain. Highly expressed in caudate/putamen, moderately expressed in the olfactory bulb. In the hippocampus, expressed in the CA1, CA2 and CA3 fields. In the cerebellum, expressed in Purkinje cells. At 15.5 dpc, predominantly expressed in skeletal muscle tissue, including diaphragm, and to a lesser extent in the central nervous system. actin binding cytoplasm transcription, DNA-templated cytoskeleton organization actin cytoskeleton myofibril lamellipodium assembly actin cytoskeleton organization positive regulation of transcription from RNA polymerase II promoter metal ion binding actin filament binding uc008xeg.1 uc008xeg.2 uc008xeg.3 uc008xeg.4 
ENSMUST00000054599.8 Sprr1a ENSMUST00000054599.8 small proline-rich protein 1A (from RefSeq NM_009264.2) ENSMUST00000054599.1 ENSMUST00000054599.2 ENSMUST00000054599.3 ENSMUST00000054599.4 ENSMUST00000054599.5 ENSMUST00000054599.6 ENSMUST00000054599.7 NM_009264 Q3UMN4 Q62266 SPR1A_MOUSE uc008qed.1 uc008qed.2 uc008qed.3 Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. May participate widely in the construction of cell envelopes in cornifying epithelia characterized by either increased thickness or a requirement for extreme flexibility. Cytoplasm. Expressed in fetal periderm, hair follicles and in the thickened epidermis of the lip and footpad. Also present in the epithelia of various tissues such as the penis, vagina, forestomach, tongue and esophagus. First detected in fetal skin around day 16 and expression continues throughout newborn and adult stages. Belongs to the cornifin (SPRR) family. cornified envelope cytoplasm peptide cross-linking keratinocyte differentiation structural constituent of epidermis keratinization cell periphery uc008qed.1 uc008qed.2 uc008qed.3 
ENSMUST00000054607.16 Ahcy ENSMUST00000054607.16 S-adenosylhomocysteine hydrolase (from RefSeq NM_016661.3) Ahcy ENSMUST00000054607.1 ENSMUST00000054607.10 ENSMUST00000054607.11 ENSMUST00000054607.12 ENSMUST00000054607.13 ENSMUST00000054607.14 ENSMUST00000054607.15 ENSMUST00000054607.2 ENSMUST00000054607.3 ENSMUST00000054607.4 ENSMUST00000054607.5 ENSMUST00000054607.6 ENSMUST00000054607.7 ENSMUST00000054607.8 ENSMUST00000054607.9 NM_016661 Q3TF14 Q3TF14_MOUSE uc008nka.1 uc008nka.2 uc008nka.3 uc008nka.4 Reaction=H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine; Xref=Rhea:RHEA:21708, ChEBI:CHEBI:15377, ChEBI:CHEBI:16335, ChEBI:CHEBI:57856, ChEBI:CHEBI:58199; EC=3.13.2.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21709; Evidence=; Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence= Note=Binds 1 NAD(+) per subunit. Amino-acid biosynthesis; L-homocysteine biosynthesis; L- homocysteine from S-adenosyl-L-homocysteine: step 1/1. Homotetramer. Interaction with AHCYL1. Belongs to the adenosylhomocysteinase family. adenosylhomocysteinase activity one-carbon metabolic process hydrolase activity uc008nka.1 uc008nka.2 uc008nka.3 uc008nka.4 
ENSMUST00000054622.15 Rtel1 ENSMUST00000054622.15 regulator of telomere elongation helicase 1, transcript variant 1 (from RefSeq NM_001001882.3) A2AU09 A2AU10 A2AU11 A2AU12 A2AU13 A2AU14 ENSMUST00000054622.1 ENSMUST00000054622.10 ENSMUST00000054622.11 ENSMUST00000054622.12 ENSMUST00000054622.13 ENSMUST00000054622.14 ENSMUST00000054622.2 ENSMUST00000054622.3 ENSMUST00000054622.4 ENSMUST00000054622.5 ENSMUST00000054622.6 ENSMUST00000054622.7 ENSMUST00000054622.8 ENSMUST00000054622.9 Kiaa1088 NM_001001882 Q0VGM9 Q3UM40 Q5F0J8 Q69ZS1 Q6H1L0 Q6H1L1 Q6H1L2 Q6H1L3 RTEL1_MOUSE Rtel uc008olv.1 uc008olv.2 uc008olv.3 uc008olv.4 ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Interacts with TERF1. Interacts (via PIP-box) with PCNA; the interaction is direct and essential for suppressing telomere fragility. Interacts with MMS19; the interaction mediates the association of RTEL1 with the cytosolic iron-sulfur protein assembly (CIA) complex. Nucleus Note=Colocalizes with PCNA within the replication foci in S-phase cells. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q0VGM9-1; Sequence=Displayed; Name=2; IsoId=Q0VGM9-2; Sequence=VSP_036949; Name=3; IsoId=Q0VGM9-3; Sequence=VSP_036947; Name=4; IsoId=Q0VGM9-4; Sequence=VSP_036950; Name=5; IsoId=Q0VGM9-5; Sequence=VSP_036948; Name=6; IsoId=Q0VGM9-6; Sequence=VSP_036945, VSP_036946; Widely expressed. Expressed in spleen, thymus, Peyer patches, kidney, and intestine. Not expressed in brain, heart, lung, skeletal muscles, skin and white fat. In the adult gonad, it is highly expressed in the testis, mainly in the spermatogonia and meiotic spermatocytes. Widely expressed in 8.5 dpc and 9.5 dpc embryos with a more restricted expression pattern at 13.5 dpc-15.5 dpc. In general, expression in embryos coincides with areas of actively proliferating cells. The PIP-box (PCNA interacting peptide) motif mediates the interaction with PCNA and localization to replication foci. Death between days 10 and 11.5 of gestation with defects in the nervous system, heart, vasculature and extraembryonic tissues. Effects are due to severe genome instability and stochastic telomere loss in embryonic stem cells which display many chromosome breaks and fusions upon differentiation in vitro. Able to elongate M.spretus telomeres in crosses between M.musculus and M.spretus. Belongs to the helicase family. RAD3/XPD subfamily. Sequence=BAD32375.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAM26418.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding telomere maintenance strand displacement chromosome, telomeric region nucleic acid binding DNA binding DNA helicase activity helicase activity protein binding ATP binding nucleus nucleobase-containing compound metabolic process DNA replication DNA repair DNA recombination cellular response to DNA damage stimulus regulation of double-strand break repair via homologous recombination hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides replication fork processing positive regulation of telomere maintenance DNA duplex unwinding telomere maintenance in response to DNA damage negative regulation of DNA recombination metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding telomeric D-loop disassembly DNA polymerase binding telomeric loop disassembly mitotic telomere maintenance via semi-conservative replication positive regulation of telomere capping positive regulation of telomere maintenance via telomere lengthening negative regulation of t-circle formation negative regulation of telomere maintenance in response to DNA damage positive regulation of telomeric loop disassembly uc008olv.1 uc008olv.2 uc008olv.3 uc008olv.4 
ENSMUST00000054635.8 Ofcc1 ENSMUST00000054635.8 orofacial cleft 1 candidate 1 (from RefSeq NM_172143.2) C3S7Q5 C3S7Q5_MOUSE ENSMUST00000054635.1 ENSMUST00000054635.2 ENSMUST00000054635.3 ENSMUST00000054635.4 ENSMUST00000054635.5 ENSMUST00000054635.6 ENSMUST00000054635.7 NM_172143 Ofcc1 opo uc011yyo.1 uc011yyo.2 uc011yyo.3 membrane integral component of membrane uc011yyo.1 uc011yyo.2 uc011yyo.3 
ENSMUST00000054636.7 Bag5 ENSMUST00000054636.7 BCL2-associated athanogene 5, transcript variant 1 (from RefSeq NM_027404.2) BAG5_MOUSE ENSMUST00000054636.1 ENSMUST00000054636.2 ENSMUST00000054636.3 ENSMUST00000054636.4 ENSMUST00000054636.5 ENSMUST00000054636.6 NM_027404 Q3TVA8 Q8CI32 Q8K175 Q9DAU0 uc007pds.1 uc007pds.2 uc007pds.3 uc007pds.4 uc007pds.5 uc007pds.6 Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (By similarity). Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (PubMed:35044787). Inhibits both auto- ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). Binds to the ATPase domain of HSP/HSP70 chaperones. Binds PRKN (By similarity). Interacts with HSPA8 (PubMed:35044787). Interacts with JPH2 (By similarity). Note=In cardiomyocytes, localized at specialized membrane contact sites between T-tubules and the sarcoplasmic reticulum, known as junctional membrane complexes. The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain. Sequence=AAH27827.1; Type=Erroneous initiation; Evidence=; Sequence=BAB24105.1; Type=Frameshift; Evidence=; protein binding nucleus mitochondrion cytosol Golgi organization negative regulation of neuron projection development inclusion body protein kinase binding negative regulation of protein ubiquitination ubiquitin protein ligase binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process perinuclear region of cytoplasm protein stabilization chaperone binding negative regulation of ubiquitin-protein transferase activity negative regulation of protein refolding neuron death regulation of inclusion body assembly negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway uc007pds.1 uc007pds.2 uc007pds.3 uc007pds.4 uc007pds.5 uc007pds.6 
ENSMUST00000054650.5 Hspb3 ENSMUST00000054650.5 heat shock protein 3 (from RefSeq NM_019960.2) ENSMUST00000054650.1 ENSMUST00000054650.2 ENSMUST00000054650.3 ENSMUST00000054650.4 HSPB3_MOUSE NM_019960 Q569N3 Q9QZ57 uc007rxi.1 uc007rxi.2 uc007rxi.3 Inhibitor of actin polymerization. Cytoplasm Nucleus Note=Translocates to nuclear foci during heat shock. Belongs to the small heat shock protein (HSP20) family. nucleus cytoplasm uc007rxi.1 uc007rxi.2 uc007rxi.3 
ENSMUST00000054651.8 Pla2g4f ENSMUST00000054651.8 phospholipase A2, group IVF, transcript variant 4 (from RefSeq NM_001363075.1) A2AQJ2 ENSMUST00000054651.1 ENSMUST00000054651.2 ENSMUST00000054651.3 ENSMUST00000054651.4 ENSMUST00000054651.5 ENSMUST00000054651.6 ENSMUST00000054651.7 NM_001363075 PA24F_MOUSE Q50L41 Q80VQ8 Q80VV9 uc008lvi.1 uc008lvi.2 uc008lvi.3 uc008lvi.4 Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:17293613, PubMed:15866882). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:17293613, PubMed:15866882). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:15866882, PubMed:17293613). In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:38783, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73001, ChEBI:CHEBI:76071; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38784; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn- glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40812; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40432; Evidence=; Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3- phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O- hexadecyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41271, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:77695, ChEBI:CHEBI:77696; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41272; Evidence=; Reaction=1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3- phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O- hexadecyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41067, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:55430, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41068; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= Stimulated by cytosolic Ca(2+). Cytoplasm, cytosol ll membrane ; Peripheral membrane protein Mitochondrion Strongly expressed in thyroid, expressed at intermediate level in stomach and at very low level in large intestine and prostate. The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity). Sequence=AAH39947.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; prostaglandin biosynthetic process phospholipase activity lysophospholipase activity phospholipase A2 activity calcium ion binding calcium-dependent phospholipid binding cytoplasm lysosome lysosomal membrane cytosol lipid metabolic process phospholipid catabolic process fatty acid transport membrane lipid catabolic process hydrolase activity vesicle ruffle membrane glycerophospholipid catabolic process metal ion binding calcium-dependent phospholipase A2 activity arachidonic acid secretion cellular response to antibiotic cellular response to organic cyclic compound uc008lvi.1 uc008lvi.2 uc008lvi.3 uc008lvi.4 
ENSMUST00000054653.9 Gm55816 ENSMUST00000054653.9 Gm55816 (from geneSymbol) AK015211 ENSMUST00000054653.1 ENSMUST00000054653.2 ENSMUST00000054653.3 ENSMUST00000054653.4 ENSMUST00000054653.5 ENSMUST00000054653.6 ENSMUST00000054653.7 ENSMUST00000054653.8 uc007bdb.1 uc007bdb.2 uc007bdb.3 uc007bdb.1 uc007bdb.2 uc007bdb.3 
ENSMUST00000054654.13 Zfp286 ENSMUST00000054654.13 zinc finger protein 286, transcript variant 1 (from RefSeq NM_138949.4) ENSMUST00000054654.1 ENSMUST00000054654.10 ENSMUST00000054654.11 ENSMUST00000054654.12 ENSMUST00000054654.2 ENSMUST00000054654.3 ENSMUST00000054654.4 ENSMUST00000054654.5 ENSMUST00000054654.6 ENSMUST00000054654.7 ENSMUST00000054654.8 ENSMUST00000054654.9 NM_138949 Q8C0E6 Q8C0E6_MOUSE Zfp286 uc007jjx.1 uc007jjx.2 uc007jjx.3 Nucleus nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007jjx.1 uc007jjx.2 uc007jjx.3 
ENSMUST00000054661.8 Adra1a ENSMUST00000054661.8 adrenergic receptor, alpha 1a, transcript variant 1 (from RefSeq NM_013461.5) ADA1A_MOUSE Adra1c ENSMUST00000054661.1 ENSMUST00000054661.2 ENSMUST00000054661.3 ENSMUST00000054661.4 ENSMUST00000054661.5 ENSMUST00000054661.6 ENSMUST00000054661.7 NM_013461 O54913 P97718 Q8BV77 uc007ukj.1 uc007ukj.2 uc007ukj.3 uc007ukj.4 This gene encodes one of several multipass transmembrane proteins that function as G protein-coupled receptors. The encoded protein binds to epinephrine and norepinephrine to mediate signaling in cells of the cardiac, nervous, and other organ systems. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]. This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Interacts with CAVIN4. Nucleus membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasm Membrane, caveola Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. Sequence=AAB47044.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure positive regulation of heart rate by epinephrine-norepinephrine positive regulation of the force of heart contraction by epinephrine-norepinephrine positive regulation of systemic arterial blood pressure G-protein coupled receptor activity adrenergic receptor activity alpha1-adrenergic receptor activity nucleus cytoplasm plasma membrane integral component of plasma membrane caveola regulation of muscle contraction signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway activation of phospholipase C activity positive regulation of cytosolic calcium ion concentration adult heart development aging response to hormone positive regulation of heart rate negative regulation of autophagy positive regulation of cardiac muscle hypertrophy membrane integral component of membrane regulation of vasoconstriction Z disc T-tubule nuclear membrane positive regulation of synaptic transmission, GABAergic negative regulation of Rho protein signal transduction organ growth response to drug positive regulation of MAPK cascade positive regulation of action potential positive regulation of vasoconstriction positive regulation of smooth muscle contraction protein heterodimerization activity regulation of cardiac muscle contraction micturition calcium ion transport into cytosol positive regulation of cardiac muscle contraction cell growth involved in cardiac muscle cell development positive regulation of ERK1 and ERK2 cascade adenylate cyclase-activating adrenergic receptor signaling pathway positive regulation of protein kinase C signaling pilomotor reflex glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane positive regulation of non-membrane spanning protein tyrosine kinase activity regulation of synaptic vesicle exocytosis uc007ukj.1 uc007ukj.2 uc007ukj.3 uc007ukj.4 
ENSMUST00000054665.10 Ankrd23 ENSMUST00000054665.10 ankyrin repeat domain 23, transcript variant 1 (from RefSeq NM_153502.4) ANR23_MOUSE Darp ENSMUST00000054665.1 ENSMUST00000054665.2 ENSMUST00000054665.3 ENSMUST00000054665.4 ENSMUST00000054665.5 ENSMUST00000054665.6 ENSMUST00000054665.7 ENSMUST00000054665.8 ENSMUST00000054665.9 NM_153502 Q812A3 uc007aql.1 uc007aql.2 uc007aql.3 uc007aql.4 May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression. Interacts with titin/TTN and MYPN. Nucleus. Note=Sarcomeric I-band and some intercalated disks. nucleus nucleoplasm cytosol fatty acid metabolic process intercalated disc actin cytoskeleton myofibril titin binding I band response to muscle stretch regulation of sarcomere organization uc007aql.1 uc007aql.2 uc007aql.3 uc007aql.4 
ENSMUST00000054691.8 Foxc2 ENSMUST00000054691.8 forkhead box C2 (from RefSeq NM_013519.2) ENSMUST00000054691.1 ENSMUST00000054691.2 ENSMUST00000054691.3 ENSMUST00000054691.4 ENSMUST00000054691.5 ENSMUST00000054691.6 ENSMUST00000054691.7 FOXC2_MOUSE Fkh14 Fkhl14 Mfh1 NM_013519 P97948 Q61850 Q63869 Q8C694 uc012glx.1 uc012glx.2 uc012glx.3 Transcriptional activator. Nucleus Expressed in the brain, muscle, heart, fat, kidney, lung, liver, uterus, ovary and testis. Expressed at 10.5 dpc to 18.5 dpc, expression peaks at 11.5 dpc and decreases thereafter (PubMed:8674414). Expressed in the non-notochordal mesoderm at 7.5 dpc (PubMed:8674414). Expressed in areas of mesenchymal condensation in the trunk, head and limbs at 8 dpc (PubMed:8674414). Widely expressed in mesenteric lymphatic endothelial cells at 16.5 dpc, expression thereafter is restricted to the lymphatic valve region at 18.5 dpc (at protein level) (PubMed:28179430). Also expressed in skin lymphatic endothelial cells at 15.5 and 18.5 dpc (PubMed:28179430). Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development ossification blood vessel development branching involved in blood vessel morphogenesis metanephros development ureteric bud development somitogenesis kidney development lymph vessel development lymphangiogenesis blood vessel remodeling heart morphogenesis DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Notch signaling pathway multicellular organism development heart development cell proliferation insulin receptor signaling pathway anatomical structure morphogenesis response to hormone positive regulation of endothelial cell migration neural crest cell development nuclear body cell differentiation collagen fibril organization chromatin DNA binding positive regulation of integrin activation positive regulation of cell adhesion mediated by integrin embryonic heart tube development positive regulation of vascular wound healing identical protein binding camera-type eye development sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of organ growth vascular endothelial growth factor receptor signaling pathway paraxial mesoderm formation paraxial mesodermal cell fate commitment embryonic cranial skeleton morphogenesis embryonic viscerocranium morphogenesis embryonic skeletal system morphogenesis artery morphogenesis ventricular cardiac muscle tissue morphogenesis cardiac muscle cell proliferation glomerular endothelium development glomerular visceral epithelial cell differentiation glomerular mesangial cell development positive regulation of cell migration involved in sprouting angiogenesis regulation of blood vessel diameter negative regulation of apoptotic process involved in outflow tract morphogenesis promoter-specific chromatin binding uc012glx.1 uc012glx.2 uc012glx.3 
ENSMUST00000054697.7 Yipf6 ENSMUST00000054697.7 Yip1 domain family, member 6 (from RefSeq NM_207633.2) ENSMUST00000054697.1 ENSMUST00000054697.2 ENSMUST00000054697.3 ENSMUST00000054697.4 ENSMUST00000054697.5 ENSMUST00000054697.6 NM_207633 Q8BR70 Q8C531 YIPF6_MOUSE uc009tve.1 uc009tve.2 uc009tve.3 uc009tve.4 May be required for stable YIPF1 and YIPF2 protein expression. Predominantly interacts with YIPF1 or YIPF2, but may also form a ternary complex with YIPF1 and YIPF2. This interaction may stabilize YIPF1 and YIPF2. Golgi apparatus membrane ; Multi-pass membrane protein Note=Evenly distributed between cis- and trans-Golgi apparatus. Mainly localizes within medial-/trans- Golgi and trans-Golgi network (TGN), while less so within cis-Golgi. Belongs to the YIP1 family. Golgi trans cisterna Golgi membrane endoplasmic reticulum Golgi apparatus Golgi medial cisterna cis-Golgi network trans-Golgi network membrane integral component of membrane ER to Golgi transport vesicle identical protein binding intestinal epithelial cell development uc009tve.1 uc009tve.2 uc009tve.3 uc009tve.4 
ENSMUST00000054708.5 Dpagt1 ENSMUST00000054708.5 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1, transcript variant 1 (from RefSeq NM_007875.3) Dpagt1 Dpagt2 ENSMUST00000054708.1 ENSMUST00000054708.2 ENSMUST00000054708.3 ENSMUST00000054708.4 GPT_MOUSE Gnpta NM_007875 P42867 Q921W5 uc009pcw.1 uc009pcw.2 uc009pcw.3 Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol. Reaction=a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N- acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP; Xref=Rhea:RHEA:13289, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9519, ChEBI:CHEBI:57683, ChEBI:CHEBI:57705, ChEBI:CHEBI:57865, ChEBI:CHEBI:58427; EC=2.7.8.15; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by mannosylphosphoryldolichol and phospholipids such as phosphatidylglycerol and phosphatidylcholine. Inhibited by natural nucleoside antibiotic tunicamycin, which acts as a structural analog and competitor of UDP-GlcNAc. Protein modification; protein glycosylation. Homodimer. Endoplasmic reticulum membrane ; Multi-pass membrane protein Highest activity is during the mid-phase of lactation. Modified_positions=74 ; Note=Partially edited.; Mice die 4 to 5 days post-fertilization, just after implantation, suggesting that protein function and N- glycosylation are essential in early embryogenesis. Belongs to the glycosyltransferase 4 family. UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity endoplasmic reticulum endoplasmic reticulum membrane UDP-N-acetylglucosamine metabolic process protein glycosylation protein N-linked glycosylation dolichol-linked oligosaccharide biosynthetic process dolichyl diphosphate biosynthetic process phospho-N-acetylmuramoyl-pentapeptide-transferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups dolichol metabolic process intracellular membrane-bounded organelle metal ion binding uc009pcw.1 uc009pcw.2 uc009pcw.3 
ENSMUST00000054716.4 Actbl2 ENSMUST00000054716.4 actin, beta-like 2 (from RefSeq NM_175497.3) ACTBL_MOUSE ENSMUST00000054716.1 ENSMUST00000054716.2 ENSMUST00000054716.3 NM_175497 Q8BFZ3 uc007rvu.1 uc007rvu.2 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with PFN1 and PFDN1 (By similarity). Cytoplasm, cytoskeleton Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization. Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity). In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Belongs to the actin family. nucleotide binding ATP binding cytoplasm cytoskeleton actin filament synapse synaptic vesicle endocytosis presynapse structural constituent of postsynaptic actin cytoskeleton postsynaptic actin cytoskeleton organization glutamatergic synapse uc007rvu.1 uc007rvu.2 
ENSMUST00000054736.4 Or5m10b ENSMUST00000054736.4 olfactory receptor family 5 subfamily M member 10B (from RefSeq NM_146589.2) ENSMUST00000054736.1 ENSMUST00000054736.2 ENSMUST00000054736.3 L7MTT3 L7MTT3_MOUSE NM_146589 Olfr1022 Or5m10b uc008klb.1 uc008klb.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008klb.1 uc008klb.2 
ENSMUST00000054738.5 Gpr151 ENSMUST00000054738.5 G protein-coupled receptor 151 (from RefSeq NM_181543.2) ENSMUST00000054738.1 ENSMUST00000054738.2 ENSMUST00000054738.3 ENSMUST00000054738.4 GP151_MOUSE NM_181543 Pgr7 Q0VBS2 Q7TSN6 Q80UD8 Q8BX88 uc008eua.1 uc008eua.2 uc008eua.3 Proton-sensing G-protein coupled receptor. Cell membrane ; Multi-pass membrane protein High expression in the brain and lower levels in kidney and liver (PubMed:14667573). In the nervous system expressed specifically in the habenular area (at protein level) (PubMed:25116430). High levels detected at 7 dpc. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway response to acidic pH membrane integral component of membrane uc008eua.1 uc008eua.2 uc008eua.3 
ENSMUST00000054742.7 Abra ENSMUST00000054742.7 actin-binding Rho activating protein (from RefSeq NM_175456.4) ABRA_MOUSE Abra ENSMUST00000054742.1 ENSMUST00000054742.2 ENSMUST00000054742.3 ENSMUST00000054742.4 ENSMUST00000054742.5 ENSMUST00000054742.6 NM_175456 Q0VB05 Q3UU01 Q8BLH3 Q8BUZ1 Q8K431 uc007vpb.1 uc007vpb.2 uc007vpb.3 Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. Binds F-actin and ABLIM1, ABLIM2 and ABLIM3. Interaction with ABLIM2 and ABLIM3 enhances activity. Cytoplasm, myofibril, sarcomere Cytoplasm, cytoskeleton Note=Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines. Expressed specifically in heart and skeletal muscle. At 8.75 dpc, expressed in the primitive heart tube. Thereafter, expression is maintained in heart and is also detected in skeletal muscle after 10.5 dpc. The actin-binding domain 1 (ABD1) is intrinsically disordered, and binds to F-actin with higher affinity than ABD2. actin binding cytoplasm cytoskeleton plasma membrane protein import into nucleus protein transport actin cytoskeleton myofibril sarcomere positive regulation of Rho protein signal transduction positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity uc007vpb.1 uc007vpb.2 uc007vpb.3 
ENSMUST00000054760.6 Rnf7l ENSMUST00000054760.6 Protein modification; protein ubiquitination. (from UniProt D3Z497) D3Z497 D3Z497_MOUSE ENSMUST00000054760.1 ENSMUST00000054760.2 ENSMUST00000054760.3 ENSMUST00000054760.4 ENSMUST00000054760.5 Gm7075 Rnf7l uc287rtt.1 uc287rtt.2 Protein modification; protein ubiquitination. Belongs to the RING-box family. molecular_function cellular_component nucleus ubiquitin-dependent protein catabolic process biological_process zinc ion binding protein ubiquitination NEDD8 transferase activity SCF-dependent proteasomal ubiquitin-dependent protein catabolic process cullin-RING ubiquitin ligase complex Cul2-RING ubiquitin ligase complex Cul3-RING ubiquitin ligase complex Cul5-RING ubiquitin ligase complex Cul7-RING ubiquitin ligase complex nuclear SCF ubiquitin ligase complex protein neddylation ubiquitin protein ligase activity Cul4-RING E3 ubiquitin ligase complex cullin family protein binding uc287rtt.1 uc287rtt.2 
ENSMUST00000054764.9 Suox ENSMUST00000054764.9 sulfite oxidase (from RefSeq NM_173733.3) ENSMUST00000054764.1 ENSMUST00000054764.2 ENSMUST00000054764.3 ENSMUST00000054764.4 ENSMUST00000054764.5 ENSMUST00000054764.6 ENSMUST00000054764.7 ENSMUST00000054764.8 NM_173733 Q3U3S5 Q3UEP6 Q8R086 SUOX_MOUSE uc007hnt.1 uc007hnt.2 uc007hnt.3 uc007hnt.4 Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids. Reaction=H2O + O2 + sulfite = H2O2 + sulfate; Xref=Rhea:RHEA:24600, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16189, ChEBI:CHEBI:16240, ChEBI:CHEBI:17359; EC=1.8.3.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24601; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit. ; Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Evidence=; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. ; Energy metabolism; sulfur metabolism. Homodimer. Mitochondrion intermembrane space Sequence=BAE32710.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; mitochondrion mitochondrial intermembrane space cytosol sulfur compound metabolic process response to nutrient sulfite oxidase activity oxidoreductase activity heme binding molybdenum ion binding nitrate assimilation molybdopterin cofactor binding metal ion binding oxidation-reduction process uc007hnt.1 uc007hnt.2 uc007hnt.3 uc007hnt.4 
ENSMUST00000054769.7 Blnk ENSMUST00000054769.7 B cell linker, transcript variant 1 (from RefSeq NM_008528.5) BLNK_MOUSE Bash ENSMUST00000054769.1 ENSMUST00000054769.2 ENSMUST00000054769.3 ENSMUST00000054769.4 ENSMUST00000054769.5 ENSMUST00000054769.6 Ly57 NM_008528 O88504 Q9QUN3 Slp65 uc008hll.1 uc008hll.2 Functions as a central linker protein, downstream of the B- cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR- mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR- induced B-cell apoptosis. Associates with PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with VAV3, PLCG2 and GRB2 (By similarity). Interacts through its SH2 domain with CD79A. Interacts (via SH2 domain) with SYK; phosphorylated and activated by SYK. Interacts (via SH2 domain) with SCIMP; this interaction is dependent on phosphorylation of SCIMP 'Tyr-120' (PubMed:21930792, PubMed:28290451). Cytoplasm Cell membrane Note=BCR activation results in the translocation to membrane fraction. Expressed in the spleen and weakly in thymus, no expression was seen in liver, testis, or brain. Expressed in B-cell lines representing different developmental stages from the pre-B to the plasma cell stage, but not in a T-cell or a fibroblast cell line. Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways (By similarity). Phosphorylation of Tyr-96 is required for the binding of BTK. SH3/SH2 adaptor activity protein binding cytoplasm plasma membrane transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of signal transduction membrane intracellular signal transduction cytoplasmic ribonucleoprotein granule B cell activation uc008hll.1 uc008hll.2 
ENSMUST00000054776.4 Plekhf2 ENSMUST00000054776.4 pleckstrin homology domain containing, family F (with FYVE domain) member 2 (from RefSeq NM_175175.4) ENSMUST00000054776.1 ENSMUST00000054776.2 ENSMUST00000054776.3 NM_175175 PKHF2_MOUSE Q91WB4 uc008ryw.1 uc008ryw.2 uc008ryw.3 uc008ryw.4 May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport (By similarity). Enhances cellular sensitivity to TNF-induced apoptosis. May interact with EEA1. Early endosome membrane ; Peripheral membrane protein Endoplasmic reticulum Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots. May translocate to the endoplasmic reticulum in the early phase of apoptosis. Expressed in brain, stomach and thymus, as well as in kidney, spleen, and skeletal muscle. Also expressed in peripheral blood mononuclear cells and dendritic cells. Up-regulated by TNF, bacterial lipopolysaccharides (LPS) and phorbol myristate acetate (PMA) (at protein level). The PH and FYVE domains may be important for TNF-induced localization to the endoplasmic reticulum and for enhanced cellular sensitivity to TNF-induced apoptosis. The FYVE domain is important for binding to the endosomal membrane (By similarity). endosome endoplasmic reticulum protein transport membrane transport vesicle early endosome membrane phosphatidylinositol binding metal ion binding uc008ryw.1 uc008ryw.2 uc008ryw.3 uc008ryw.4 
ENSMUST00000054780.10 Zfp959 ENSMUST00000054780.10 zinc finger protein 959, transcript variant 1 (from RefSeq NM_145490.5) BC011426 ENSMUST00000054780.1 ENSMUST00000054780.2 ENSMUST00000054780.3 ENSMUST00000054780.4 ENSMUST00000054780.5 ENSMUST00000054780.6 ENSMUST00000054780.7 ENSMUST00000054780.8 ENSMUST00000054780.9 NM_145490 Q91VM8 Q91VM8_MOUSE Zfp959 uc008dag.1 uc008dag.2 uc008dag.3 uc008dag.4 molecular_function nucleic acid binding nucleus regulation of transcription, DNA-templated metal ion binding uc008dag.1 uc008dag.2 uc008dag.3 uc008dag.4 
ENSMUST00000054781.7 Gm20715 ENSMUST00000054781.7 Gm20715 (from geneSymbol) AK029628 E9Q3L7 E9Q3L7_MOUSE ENSMUST00000054781.1 ENSMUST00000054781.2 ENSMUST00000054781.3 ENSMUST00000054781.4 ENSMUST00000054781.5 ENSMUST00000054781.6 Gm16532 Gm20715 uc009fbl.1 uc009fbl.2 uc009fbl.3 uc009fbl.4 uc009fbl.1 uc009fbl.2 uc009fbl.3 uc009fbl.4 
ENSMUST00000054786.6 Igbp1b ENSMUST00000054786.6 immunoglobulin (CD79A) binding protein 1b (from RefSeq NM_015777.3) A0A0B4J1F7 A0A0B4J1F7_MOUSE ENSMUST00000054786.1 ENSMUST00000054786.2 ENSMUST00000054786.3 ENSMUST00000054786.4 ENSMUST00000054786.5 Igbp1b NM_015777 uc009enq.1 uc009enq.2 uc009enq.3 uc009enq.4 uc009enq.5 Belongs to the IGBP1/TAP42 family. regulation of signal transduction uc009enq.1 uc009enq.2 uc009enq.3 uc009enq.4 uc009enq.5 
ENSMUST00000054791.9 Vtcn1 ENSMUST00000054791.9 V-set domain containing T cell activation inhibitor 1, transcript variant 1 (from RefSeq NM_178594.4) B7h4 ENSMUST00000054791.1 ENSMUST00000054791.2 ENSMUST00000054791.3 ENSMUST00000054791.4 ENSMUST00000054791.5 ENSMUST00000054791.6 ENSMUST00000054791.7 ENSMUST00000054791.8 NM_178594 Q7TPH5 Q7TSP5 Q8K091 VTCN1_MOUSE Vtcn1 uc008qqx.1 uc008qqx.2 uc008qqx.3 Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T- cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Cell membrane ipid- anchor, GPI-anchor Note=Expressed at the cell surface. A soluble form has also been detected. Expressed on the surface of professional antigen- presenting cells (at protein level). Widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. Down-regulated upon activation of B-cells. N-glycosylated. Mice mount mildy augmented T-helper 1 responses and display slightly lowered parasitic burdens upon Leishmania major infection. Belongs to the immunoglobulin superfamily. BTN/MOG family. response to protozoan adaptive immune response immune system process receptor binding plasma membrane external side of plasma membrane membrane anchored component of membrane positive regulation of T cell proliferation negative regulation of T cell proliferation negative regulation of apoptotic process regulation of immune response T cell receptor signaling pathway negative regulation of T cell activation interleukin-4 secretion interferon-gamma secretion positive regulation of interleukin-2 secretion uc008qqx.1 uc008qqx.2 uc008qqx.3 
ENSMUST00000054799.9 BC048671 ENSMUST00000054799.9 cDNA sequence BC048671, transcript variant 1 (from RefSeq NM_177738.3) CC022_MOUSE ENSMUST00000054799.1 ENSMUST00000054799.2 ENSMUST00000054799.3 ENSMUST00000054799.4 ENSMUST00000054799.5 ENSMUST00000054799.6 ENSMUST00000054799.7 ENSMUST00000054799.8 NM_177738 Q8C5S3 uc009cxa.1 uc009cxa.2 uc009cxa.3 molecular_function cellular_component biological_process uc009cxa.1 uc009cxa.2 uc009cxa.3 
ENSMUST00000054801.4 Mettl21e ENSMUST00000054801.4 methyltransferase like 21E (from RefSeq NM_207281.3) ENSMUST00000054801.1 ENSMUST00000054801.2 ENSMUST00000054801.3 MT21E_MOUSE NM_207281 Q8CDZ2 uc007awk.1 uc007awk.2 uc007awk.3 Protein-lysine methyltransferase. Belongs to the methyltransferase superfamily. METTL21 family. molecular_function cellular_component biological_process methyltransferase activity transferase activity methylation uc007awk.1 uc007awk.2 uc007awk.3 
ENSMUST00000054815.15 Ppp1r13b ENSMUST00000054815.15 protein phosphatase 1, regulatory subunit 13B (from RefSeq NM_011625.1) ASPP1_MOUSE Aspp1 ENSMUST00000054815.1 ENSMUST00000054815.10 ENSMUST00000054815.11 ENSMUST00000054815.12 ENSMUST00000054815.13 ENSMUST00000054815.14 ENSMUST00000054815.2 ENSMUST00000054815.3 ENSMUST00000054815.4 ENSMUST00000054815.5 ENSMUST00000054815.6 ENSMUST00000054815.7 ENSMUST00000054815.8 ENSMUST00000054815.9 NM_011625 Q62415 uc007ped.1 uc007ped.2 uc007ped.3 Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (By similarity). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo (By similarity). Interacts with P53/TP53; the interaction promotes pro- apoptotic activity. Cytoplasm Nucleus Note=Predominantly cytoplasmic (By similarity). Some fraction is nuclear. The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53. In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1. Belongs to the ASPP family. p53 binding nucleus nucleoplasm cytoplasm cytosol plasma membrane apoptotic process transcription factor binding negative regulation of cell cycle perinuclear region of cytoplasm intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of neuron death uc007ped.1 uc007ped.2 uc007ped.3 
ENSMUST00000054819.10 Sox14 ENSMUST00000054819.10 SRY (sex determining region Y)-box 14 (from RefSeq NM_011440.1) ENSMUST00000054819.1 ENSMUST00000054819.2 ENSMUST00000054819.3 ENSMUST00000054819.4 ENSMUST00000054819.5 ENSMUST00000054819.6 ENSMUST00000054819.7 ENSMUST00000054819.8 ENSMUST00000054819.9 NM_011440 Q3UUP3 Q3UUP3_MOUSE Sox14 uc012gzb.1 uc012gzb.2 DNA binding nucleus regulation of transcription, DNA-templated uc012gzb.1 uc012gzb.2 
ENSMUST00000054825.5 Rarres1 ENSMUST00000054825.5 retinoic acid receptor responder (tazarotene induced) 1 (from RefSeq NM_001164763.1) ENSMUST00000054825.1 ENSMUST00000054825.2 ENSMUST00000054825.3 ENSMUST00000054825.4 F6ZIS7 F6ZIS7_MOUSE NM_001164763 Rarres1 uc008plo.1 uc008plo.2 uc008plo.3 uc008plo.4 Belongs to the protease inhibitor I47 (latexin) family. extracellular space biological_process metalloendopeptidase inhibitor activity negative regulation of endopeptidase activity uc008plo.1 uc008plo.2 uc008plo.3 uc008plo.4 
ENSMUST00000054829.13 Krtcap3 ENSMUST00000054829.13 keratinocyte associated protein 3, transcript variant 2 (from RefSeq NM_027221.3) ENSMUST00000054829.1 ENSMUST00000054829.10 ENSMUST00000054829.11 ENSMUST00000054829.12 ENSMUST00000054829.2 ENSMUST00000054829.3 ENSMUST00000054829.4 ENSMUST00000054829.5 ENSMUST00000054829.6 ENSMUST00000054829.7 ENSMUST00000054829.8 ENSMUST00000054829.9 KCP3_MOUSE NM_027221 Q8K177 Q9D8I7 uc008wxz.1 uc008wxz.2 uc008wxz.3 Membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K177-1; Sequence=Displayed; Name=2; IsoId=Q8K177-2; Sequence=VSP_017531; Belongs to the TMEM54 family. Sequence=AAH27812.1; Type=Erroneous initiation; Evidence=; Sequence=AAI07025.1; Type=Erroneous initiation; Evidence=; Sequence=AAI07026.1; Type=Erroneous initiation; Evidence=; Sequence=BAB25399.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008wxz.1 uc008wxz.2 uc008wxz.3 
ENSMUST00000054835.15 Ercc8 ENSMUST00000054835.15 excision repaiross-complementing rodent repair deficiency, complementation group 8, transcript variant 1 (from RefSeq NM_028042.4) Ckn1 Csa ENSMUST00000054835.1 ENSMUST00000054835.10 ENSMUST00000054835.11 ENSMUST00000054835.12 ENSMUST00000054835.13 ENSMUST00000054835.14 ENSMUST00000054835.2 ENSMUST00000054835.3 ENSMUST00000054835.4 ENSMUST00000054835.5 ENSMUST00000054835.6 ENSMUST00000054835.7 ENSMUST00000054835.8 ENSMUST00000054835.9 ERCC8_MOUSE NM_028042 Q3U066 Q8CFD5 Q8VDC4 Q9CWK7 uc007rux.1 uc007rux.2 uc007rux.3 Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair (By similarity). The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair (By similarity). It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (By similarity). Plays a role in DNA single-strand and double-strand breaks (DSSBs) repair; involved in repair of DSSBs by non-homologous end joining (NHEJ) (By similarity). Protein modification; protein ubiquitination. Part of the CSA complex (DCX(ERCC8) complex), a DCX E3 ubiquitin-protein ligase complex containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II. Interacts with ERCC6 and KIAA1530/UVSSA. Interacts with a subunit of RNA polymerase II TFIIH. Interacts with DDB1. Q8CFD5; Q3U4B1: Ssbp4; NbExp=2; IntAct=EBI-26682118, EBI-26666280; Nucleus Nucleus matrix Note=UV-induced translocation to the nuclear matrix is dependent on ERCC6. Ercc8 deficient mice develop normally, but show a loss of retinal photoreceptors after 4 months of age, and enhanced UV- sensitivity. nucleotide-excision repair complex protein polyubiquitination ubiquitin-protein transferase activity nucleus cytoplasm DNA repair transcription-coupled nucleotide-excision repair nucleotide-excision repair cellular response to DNA damage stimulus response to oxidative stress response to UV response to X-ray response to auditory stimulus response to organic cyclic compound nuclear matrix protein ubiquitination Cul4A-RING E3 ubiquitin ligase complex macromolecular complex proteasome-mediated ubiquitin-dependent protein catabolic process perikaryon macromolecular complex binding positive regulation of DNA repair protein autoubiquitination Cul4-RING E3 ubiquitin ligase complex uc007rux.1 uc007rux.2 uc007rux.3 
ENSMUST00000054836.7 Hrk ENSMUST00000054836.7 harakiri, BCL2 interacting protein (contains only BH3 domain) (from RefSeq NM_007545.2) Bid3 Dp5 ENSMUST00000054836.1 ENSMUST00000054836.2 ENSMUST00000054836.3 ENSMUST00000054836.4 ENSMUST00000054836.5 ENSMUST00000054836.6 HRK_MOUSE NM_007545 P62816 P70678 uc008zgg.1 uc008zgg.2 uc008zgg.3 Promotes apoptosis. Interacts with BCL2 and BCL2L1. Interacts with C1QBP (By similarity). Membrane ; Single-pass membrane protein Mitochondrion The BH3 motif is required for the induction of cell death. mitochondrion apoptotic process membrane integral component of membrane positive regulation of protein complex assembly regulation of apoptotic process positive regulation of apoptotic process positive regulation of neuron apoptotic process cellular response to potassium ion starvation positive regulation of release of cytochrome c from mitochondria uc008zgg.1 uc008zgg.2 uc008zgg.3 
ENSMUST00000054837.6 1700120B22Rik ENSMUST00000054837.6 1700120B22Rik (from geneSymbol) AK006818 ENSMUST00000054837.1 ENSMUST00000054837.2 ENSMUST00000054837.3 ENSMUST00000054837.4 ENSMUST00000054837.5 uc007fjz.1 uc007fjz.2 uc007fjz.3 uc007fjz.4 uc007fjz.1 uc007fjz.2 uc007fjz.3 uc007fjz.4 
ENSMUST00000054857.13 Fam110b ENSMUST00000054857.13 family with sequence similarity 110, member B, transcript variant 1 (from RefSeq NM_173426.3) ENSMUST00000054857.1 ENSMUST00000054857.10 ENSMUST00000054857.11 ENSMUST00000054857.12 ENSMUST00000054857.2 ENSMUST00000054857.3 ENSMUST00000054857.4 ENSMUST00000054857.5 ENSMUST00000054857.6 ENSMUST00000054857.7 ENSMUST00000054857.8 ENSMUST00000054857.9 F110B_MOUSE NM_173426 Q3UKH0 Q8C739 uc008rxe.1 uc008rxe.2 uc008rxe.3 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Belongs to the FAM110 family. molecular_function cytoplasm mitochondrion microtubule organizing center cytosol cytoskeleton biological_process uc008rxe.1 uc008rxe.2 uc008rxe.3 
ENSMUST00000054865.13 Cfap69 ENSMUST00000054865.13 cilia and flagella associated protein 69 (from RefSeq NM_172447.2) CFA69_MOUSE Cfap69 ENSMUST00000054865.1 ENSMUST00000054865.10 ENSMUST00000054865.11 ENSMUST00000054865.12 ENSMUST00000054865.2 ENSMUST00000054865.3 ENSMUST00000054865.4 ENSMUST00000054865.5 ENSMUST00000054865.6 ENSMUST00000054865.7 ENSMUST00000054865.8 ENSMUST00000054865.9 NM_172447 Q3TPR3 Q8BH53 Q8CA81 Q8CDU8 uc008wiu.1 uc008wiu.2 uc008wiu.3 Cilium- and flagellum-associated protein (PubMed:28495971, PubMed:29606301). In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (PubMed:28495971). Required for sperm flagellum assembly and stability (PubMed:29606301). Cell projection, cilium Cell projection, cilium, flagellum Note=Localizes to the midpiece of the sperm flagellum. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BH53-1; Sequence=Displayed; Name=2; IsoId=Q8BH53-2; Sequence=VSP_031677, VSP_031679; Name=3; IsoId=Q8BH53-3; Sequence=VSP_031678, VSP_031680; Name=4; IsoId=Q8BH53-4; Sequence=VSP_031681, VSP_031682; Expressed in ciliated olfactory sensory neurons (at protein level) (PubMed:28495971). Expressed in testis, specifically in sperm (at protein level) (PubMed:29606301). Detected in pachytene spermatocytes and has increased expression in early and late spermatids. Male mice are infertile due to disrupted sperm flagellum assembly. molecular_function cytoplasm cilium spermatogenesis sensory perception of smell cell differentiation motile cilium olfactory behavior cell projection response to stimulus sperm midpiece non-motile cilium positive regulation of flagellated sperm motility positive regulation of fertilization response to odorant uc008wiu.1 uc008wiu.2 uc008wiu.3 
ENSMUST00000054867.8 Gpr37 ENSMUST00000054867.8 G protein-coupled receptor 37 (from RefSeq NM_010338.2) ENSMUST00000054867.1 ENSMUST00000054867.2 ENSMUST00000054867.3 ENSMUST00000054867.4 ENSMUST00000054867.5 ENSMUST00000054867.6 ENSMUST00000054867.7 GPR37_MOUSE NM_010338 Q8BKF8 Q8BXP9 Q8C022 Q9QY42 Q9Z0G3 uc009bcd.1 uc009bcd.2 uc009bcd.3 uc009bcd.4 G-protein-coupled receptor that plays a role in several physiological pathways such as resolution of inflammatory pain and oligodendrocyte differentiation (PubMed:26961174, PubMed:28642167, PubMed:30010619). Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity). Acts as a receptor for osteocalcin (OCN) to regulate oligodendrocyte differentiation and central nervous system myelination (PubMed:34678058). Mechanistically, plays a negative role in oligodendrocyte differentiation and myelination during development via activation of the ERK1/2 signaling pathway (PubMed:26961174). Therefore, regulates the stability of myelin or resistance of myelin itself to demyelination (PubMed:28642167). Upon activation by neuroprotectin D1 (NPD1), promotes the activation of phagocytosis in macrophages as well as the shift in cytokine release toward an anti- inflammatory profile, and thus helps to reverse inflammatory pain (PubMed:30010619). In addition, the increased macrophage phagocytosis mediates protection against sepsis upon pathogen infection (PubMed:33731716). Additionally, extracellular vesicles derived from efferocyte express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor TIM4 via an ERK-AP1- dependent signaling axis, leading to increased macrophage efferocytosis efficiency and accelerated resolution of inflammation (PubMed:37436891). May also act as a maturation factor of LRP6, protecting LRP6 from the endoplasmic reticulum (ER)-associated protein degradation (ERAD) and thereby promoting the Wnt/beta-catenin signaling pathway (By similarity). Forms a complex with PRKN, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PRKN, thus facilitating PRKN-mediated GPR37 ubiquitination. Interacts with PACRG (By similarity). Cell projection, dendrite Synapse Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9QY42-1; Sequence=Displayed; Name=2; IsoId=Q9QY42-2; Sequence=VSP_011762; Name=3; IsoId=Q9QY42-3; Sequence=VSP_011763, VSP_011764; Highly expressed in oligodendrocytes in the brain and spinal cord and expression increases during their differentiation into myelin forming cells. The N-terminus is cleaved by ADAM10 metalloproteinase; mediating limited proteolysis leading to the release of receptor ectodomain by shedding. In addition, cleaved by FURIN between Arg-53 and Asp-54. Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death. GPR37-deletion mice exhibit a significantly higher number of myelinated axons and thicker myelin profiles than wild-type mice. Therefore, deletion results in accelerated myelination (PubMed:26961174, PubMed:28642167). In addition, mutant mice exhibit enhanced Listeria monocytogenes-induced pain behaviors compared to WT (PubMed:33731716). Belongs to the G-protein coupled receptor 1 family. ubiquitin ligase complex G-protein coupled receptor activity endoplasmic reticulum endoplasmic reticulum membrane plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane Hsp70 protein binding heat shock protein binding ubiquitin protein ligase binding locomotion involved in locomotory behavior prosaposin receptor activity peptide binding dopamine biosynthetic process receptor complex positive regulation of MAPK cascade positive regulation of dopamine metabolic process negative regulation of hydrogen peroxide-induced cell death uc009bcd.1 uc009bcd.2 uc009bcd.3 uc009bcd.4 
ENSMUST00000054868.2 Or8k16 ENSMUST00000054868.2 olfactory receptor family 8 subfamily K member 16 (from RefSeq NM_146866.1) ENSMUST00000054868.1 NM_146866 Olfr1008 Or8k16 Q8VGC7 Q8VGC7_MOUSE uc008kkq.1 uc008kkq.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kkq.1 uc008kkq.2 
ENSMUST00000054871.12 Fpr3 ENSMUST00000054871.12 Low affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states. (from UniProt O08790) ENSMUST00000054871.1 ENSMUST00000054871.10 ENSMUST00000054871.11 ENSMUST00000054871.2 ENSMUST00000054871.3 ENSMUST00000054871.4 ENSMUST00000054871.5 ENSMUST00000054871.6 ENSMUST00000054871.7 ENSMUST00000054871.8 ENSMUST00000054871.9 FPRS1_MOUSE Fpr-s1 Fpr2 Fprl1 Lxa4r O08790 O88535 U78299 uc008apv.1 uc008apv.2 uc008apv.3 Low affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states. Cell membrane; Multi-pass membrane protein. Expressed exclusively in vomeronasal neurons (PubMed:19387439, PubMed:19497865). Expressed in 0.6 % of a subset of sensory neurons located in the basal layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed mostly in neutrophils, followed by spleen and lung and expressed at very low levels in heart and liver (PubMed:19387439). Belongs to the G-protein coupled receptor 1 family. Name=Protein Spotlight; Note=A sickly smell - Issue 114 of February 2010; URL="https://web.expasy.org/spotlight/back_issues/114"; complement receptor mediated signaling pathway G-protein coupled receptor activity N-formyl peptide receptor activity plasma membrane chemotaxis inflammatory response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane signaling receptor activity uc008apv.1 uc008apv.2 uc008apv.3 
ENSMUST00000054889.4 Cldn2 ENSMUST00000054889.4 claudin 2, transcript variant 1 (from RefSeq NM_016675.5) CLD2_MOUSE ENSMUST00000054889.1 ENSMUST00000054889.2 ENSMUST00000054889.3 NM_016675 O88552 uc009ukl.1 uc009ukl.2 uc009ukl.3 uc009ukl.4 uc009ukl.5 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene display normal appearance, activity, growth and behavior, but are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. The proteins encoded by this gene and another family member Cldn12 are also critical for vitamin D-dependent Ca2+ absorption between enterocytes. [provided by RefSeq, Aug 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY075485.1, BC085494.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Expressed in the kidney, liver and intestine, with higher levels in the ileum than in the jejunum. Low levels in the brain. By CDX1 and CDX2. Induction by CDX2, but not CDX1, is potentiated by TCF1. The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking. Both female and male Cldn2-knockout mice are similarly hypercalciuric compared to wild-type littermates. Cldn2-null mice are hypercalciuric due to a primary defect in renal tubule calcium transport and develop papillary nephrocalcinosis. Cldn2-null mice are also found to have increased net intestinal calcium absorption, but reduced paracellular calcium permeability in the colon, suggesting reduced intestinal calcium secretion. Belongs to the claudin family. structural molecule activity protein binding plasma membrane bicellular tight junction membrane integral component of membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding uc009ukl.1 uc009ukl.2 uc009ukl.3 uc009ukl.4 uc009ukl.5 
ENSMUST00000054908.10 Sugt1 ENSMUST00000054908.10 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) (from RefSeq NM_026474.6) ENSMUST00000054908.1 ENSMUST00000054908.2 ENSMUST00000054908.3 ENSMUST00000054908.4 ENSMUST00000054908.5 ENSMUST00000054908.6 ENSMUST00000054908.7 ENSMUST00000054908.8 ENSMUST00000054908.9 NM_026474 Q3UF88 Q9CRE7 Q9CX34 Q9D8M6 SGT1_MOUSE Sugt1 uc007ute.1 uc007ute.2 uc007ute.3 May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90 (By similarity). Cytoplasm Nucleus Note=Translocates the to nucleus upon heat shock, requiring S100A6. The CS domain mediates interaction with HSP90. Phosphorylated at Ser-252 and Ser-302, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex. Belongs to the SGT1 family. molecular_function nucleus cytoplasm regulation of protein stability macromolecular complex positive regulation by host of symbiont catalytic activity protein stabilization uc007ute.1 uc007ute.2 uc007ute.3 
ENSMUST00000054920.5 Myorg ENSMUST00000054920.5 myogenesis regulating glycosidase (putative) (from RefSeq NM_001085515.2) A2ANN6 B2RU42 ENSMUST00000054920.1 ENSMUST00000054920.2 ENSMUST00000054920.3 ENSMUST00000054920.4 Kiaa1161 MYORG_MOUSE NM_001085515 Net37 Q69ZQ1 uc008sit.1 uc008sit.2 uc008sit.3 uc008sit.4 Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2 (PubMed:19706595). Interacts with IGF2; this interaction is required for IGF2 secretion (PubMed:19706595). Nucleus membrane ingle-pass type II membrane protein Endoplasmic reticulum membrane ; Single-pass type II membrane protein Note=Only a minor fraction is present in the peripheral endoplasmic reticulum (PubMed:19706595). Expressed in brain, liver, spleen, skeletal muscle, heart, lung and kidney (PubMed:29910000). High expression is observed in the cerebellum, specifically in astrocytes (PubMed:29910000). Highly expressed in skeletal muscle (at protein level) (PubMed:19706595). Up-regulated during C2C12 myogenic differentiation. Knockout mice develop bilateral calcifications in the thalamus, due to the formation of calcium phosphate deposits. The requirement of the predicted catalytic residue Asp- 462 to support myogenic function strongly suggests that MYORG is an enzymatically active glycosidase in vivo, even if concrete experimental proof for enzymatic activity is still missing. Belongs to the glycosyl hydrolase 31 family. Sequence=BAD32395.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; hydrolase activity, hydrolyzing O-glycosyl compounds protein binding nucleus endoplasmic reticulum endoplasmic reticulum membrane carbohydrate metabolic process metabolic process membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds nuclear membrane positive regulation of insulin-like growth factor receptor signaling pathway skeletal muscle fiber development positive regulation of protein kinase B signaling uc008sit.1 uc008sit.2 uc008sit.3 uc008sit.4 
ENSMUST00000054930.7 Ptx4 ENSMUST00000054930.7 pentraxin 4, transcript variant 1 (from RefSeq NM_026747.1) E9QNW3 E9QNW3_MOUSE ENSMUST00000054930.1 ENSMUST00000054930.2 ENSMUST00000054930.3 ENSMUST00000054930.4 ENSMUST00000054930.5 ENSMUST00000054930.6 NM_026747 Ptx4 uc008azu.1 uc008azu.2 uc008azu.3 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Lacks conserved residue(s) required for the propagation of feature annotation. uc008azu.1 uc008azu.2 uc008azu.3 
ENSMUST00000054932.13 Prl2c1 ENSMUST00000054932.13 Prolactin family 2, subfamily c, member 1, transcript variant 1 (from RefSeq NM_001045532.2) ENSMUST00000054932.1 ENSMUST00000054932.10 ENSMUST00000054932.11 ENSMUST00000054932.12 ENSMUST00000054932.2 ENSMUST00000054932.3 ENSMUST00000054932.4 ENSMUST00000054932.5 ENSMUST00000054932.6 ENSMUST00000054932.7 ENSMUST00000054932.8 ENSMUST00000054932.9 NM_001045532 Prl2c1 Q5SVM0 Q5SVM0_MOUSE uc007pyf.1 uc007pyf.2 uc007pyf.3 uc007pyf.4 Secreted Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pyf.1 uc007pyf.2 uc007pyf.3 uc007pyf.4 
ENSMUST00000054952.4 Emc6 ENSMUST00000054952.4 ER membrane protein complex subunit 6, transcript variant 2 (from RefSeq NM_025318.3) EMC6_MOUSE ENSMUST00000054952.1 ENSMUST00000054952.2 ENSMUST00000054952.3 NM_025318 Q9CQ41 Q9CQW0 Tmem93 uc007kab.1 uc007kab.2 uc007kab.3 uc007kab.4 Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N- exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Component of the ER membrane protein complex (EMC). Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the EMC6 family. autophagosome assembly molecular_function endoplasmic reticulum membrane integral component of membrane integral component of endoplasmic reticulum membrane ER membrane protein complex integral component of omegasome membrane uc007kab.1 uc007kab.2 uc007kab.3 uc007kab.4 
ENSMUST00000054960.9 Irf2bp2 ENSMUST00000054960.9 interferon regulatory factor 2 binding protein 2 (from RefSeq NM_001164598.3) E9Q1P8 ENSMUST00000054960.1 ENSMUST00000054960.2 ENSMUST00000054960.3 ENSMUST00000054960.4 ENSMUST00000054960.5 ENSMUST00000054960.6 ENSMUST00000054960.7 ENSMUST00000054960.8 I2BP2_MOUSE NM_001164598 Q8BJC6 uc009nyw.1 uc009nyw.2 uc009nyw.3 uc009nyw.4 Acts as a transcriptional corepressor in a IRF2-dependent manner, this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT- responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles. Plays a role in immature B-cell differentiation (By similarity). Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP1. Interacts with VGLL4 (By similarity). Cytoplasm Nucleus The C-terminal RING-type zinc finger domain is sufficient for interaction with IRF2. Phosphorylation at Ser-343 is required for nuclear targeting. Belongs to the IRF2BP family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding immature B cell differentiation transcription corepressor activity nucleus nucleoplasm cytoplasm positive regulation of transcription from RNA polymerase II promoter metal ion binding uc009nyw.1 uc009nyw.2 uc009nyw.3 uc009nyw.4 
ENSMUST00000054974.2 Or10ag2 ENSMUST00000054974.2 olfactory receptor family 10 subfamily AG member 2 (from RefSeq NM_146350.2) A2AT85 A2AT85_MOUSE ENSMUST00000054974.1 NM_146350 Olfr1123 Or10ag2 uc008knx.1 uc008knx.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008knx.1 uc008knx.2 
ENSMUST00000054979.10 Aff1 ENSMUST00000054979.10 AF4/FMR2 family, member 1, transcript variant 2 (from RefSeq NM_133919.5) A3KMF4 A3KMF4_MOUSE Aff1 ENSMUST00000054979.1 ENSMUST00000054979.2 ENSMUST00000054979.3 ENSMUST00000054979.4 ENSMUST00000054979.5 ENSMUST00000054979.6 ENSMUST00000054979.7 ENSMUST00000054979.8 ENSMUST00000054979.9 NM_133919 uc008yjt.1 uc008yjt.2 This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. Knockout of the mouse gene by homologous recombination severely affects early events in lymphopoiesis, including precursor proliferation or recruitment, but is dispensable for terminal differentiation. In addition, an autosomal dominant missense mutation results in several phenotypes including ataxia and adult-onset Purkinje cell loss in the cerebellum, indicating a role in Purkinje cell maintenance and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]. Belongs to the AF4 family. uc008yjt.1 uc008yjt.2 
ENSMUST00000054984.8 Sft2d3 ENSMUST00000054984.8 SFT2 domain containing 3 (from RefSeq NM_026006.1) E9QJT3 ENSMUST00000054984.1 ENSMUST00000054984.2 ENSMUST00000054984.3 ENSMUST00000054984.4 ENSMUST00000054984.5 ENSMUST00000054984.6 ENSMUST00000054984.7 NM_026006 Q9CSV6 SFT2C_MOUSE Sft2d3 uc008eiu.1 uc008eiu.2 uc008eiu.3 uc008eiu.4 May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Membrane ; Multi-pass membrane protein Belongs to the SFT2 family. Sequence=BAB27904.1; Type=Frameshift; Evidence=; molecular_function protein transport membrane integral component of membrane vesicle-mediated transport uc008eiu.1 uc008eiu.2 uc008eiu.3 uc008eiu.4 
ENSMUST00000055006.12 Trim16 ENSMUST00000055006.12 tripartite motif-containing 16 (from RefSeq NM_053169.2) ENSMUST00000055006.1 ENSMUST00000055006.10 ENSMUST00000055006.11 ENSMUST00000055006.2 ENSMUST00000055006.3 ENSMUST00000055006.4 ENSMUST00000055006.5 ENSMUST00000055006.6 ENSMUST00000055006.7 ENSMUST00000055006.8 ENSMUST00000055006.9 NM_053169 Q5SVT2 Q5SVT2_MOUSE Trim16 uc007jka.1 uc007jka.2 uc007jka.3 zinc ion binding uc007jka.1 uc007jka.2 uc007jka.3 
ENSMUST00000055009.15 Dcaf1 ENSMUST00000055009.15 DDB1 and CUL4 associated factor 1, transcript variant 2 (from RefSeq NM_001373931.1) DCAF1_MOUSE Dcaf1 ENSMUST00000055009.1 ENSMUST00000055009.10 ENSMUST00000055009.11 ENSMUST00000055009.12 ENSMUST00000055009.13 ENSMUST00000055009.14 ENSMUST00000055009.2 ENSMUST00000055009.3 ENSMUST00000055009.4 ENSMUST00000055009.5 ENSMUST00000055009.6 ENSMUST00000055009.7 ENSMUST00000055009.8 ENSMUST00000055009.9 Kiaa0800 NM_001373931 Q3UXD5 Q6P1E2 Q80TR8 Q8CDY3 Vprbp uc292krr.1 uc292krr.2 Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine- protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin- protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex. The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B- cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition. Also acts as an atypical serine/threonine- protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors. Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2. By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (PubMed:24357321). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Protein modification; protein ubiquitination. Component of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex. Interacts with DDB1; the interaction is direct. Also forms a ternary complex with DDA1 and DDB1. Interacts with NF2 (via FERM domain). Component of the EDVP complex, a E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1. Interacts with DYRK2; the interaction is direct. Interacts with RAG1; the interaction is direct. Interacts with LLGL1 and LLGL2. Interacts with histone H3. Interacts with ESR1 and LATS1; probably recruited by LATS1 to promote ESR1 ubiquitination and ubiquitin- mediated proteasomal degradation. Directly interacts with TET1, TET2 and TET3 (via C-terminus) (By similarity). Cytoplasm Nucleus te=Associated with chromatin in a DDB1- independent and cell cycle-dependent manner: recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis. Homogenous pancellular distribution is observed outside S-phase and a slight cytoplasmic-to-nuclear translocation from early to late S-phase. Colocalizes with TET1 and PCNA at replicating heterochromatin during late S phase (PubMed:36056023). More concentrated in nuclei than in cytoplasm in germinal vesicle (GV) stage oocytes, zygotes and the 2- cell stage, but distributed in the cytoplasm at the MII-stage oocytes (PubMed:24357321). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80TR8-1; Sequence=Displayed; Name=2; IsoId=Q80TR8-2; Sequence=VSP_025502; Name=3; IsoId=Q80TR8-3; Sequence=VSP_025500, VSP_025501; Name=4; IsoId=Q80TR8-4; Sequence=VSP_025503, VSP_025504; Widely expressed (PubMed:11223251). Expressed in oocytes and zygotes (at protein level) (PubMed:24357321, PubMed:25557551). Expressed at high levels in germinal vesicle (GV) stage oocytes and at lower levels in MII-stage oocytes and zygotes (PubMed:24357321). Expression decreases from 4-cell stage to blastula (PubMed:24357321). The protein kinase-like region mediates the threonine-protein kinase activity. The DWD boxes are required for interaction with DDB1. The chromo domain with a restricted pocket directly recognizes monomethylated substrates. Early embryonic lethality. Conditional knockout in mouse embryonic fibroblasts results in severely defective progression through S phase and subsequent apoptosis (PubMed:18606781). Conditional knockout in B lineage-specific cells arrests B-cell development at the pro-B-to-pre-B cell transition: mice display modest reduction of D-J(H) rearrangement, while V(H)-DJ(H) and V(kappa)- J(kappa) rearrangements are severely impaired. D-J(H) coding joints show longer junctional nucleotide insertions and a higher mutation frequency in D and J segments than normal (PubMed:22157821). Belongs to the VPRBP/DCAF1 family. Sequence=BAC65654.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleotide binding fibrillar center protein serine/threonine kinase activity ATP binding nucleus cytoplasm chromatin organization COP9 signalosome viral process kinase activity phosphorylation protein ubiquitination transferase activity B cell differentiation estrogen receptor binding V(D)J recombination cell competition in a multicellular organism Cul4-RING E3 ubiquitin ligase complex histone kinase activity (H2A-T120 specific) histone H2A-T120 phosphorylation uc292krr.1 uc292krr.2 
ENSMUST00000055022.15 Tpra1 ENSMUST00000055022.15 Membrane; Multi-pass membrane protein. (from UniProt Q99MU1) AK155116 ENSMUST00000055022.1 ENSMUST00000055022.10 ENSMUST00000055022.11 ENSMUST00000055022.12 ENSMUST00000055022.13 ENSMUST00000055022.14 ENSMUST00000055022.2 ENSMUST00000055022.3 ENSMUST00000055022.4 ENSMUST00000055022.5 ENSMUST00000055022.6 ENSMUST00000055022.7 ENSMUST00000055022.8 ENSMUST00000055022.9 Gpr175 Q80UD9 Q8C240 Q91Z36 Q99MU1 Q9Z112 TPRA1_MOUSE Tpra40 uc009cvy.1 uc009cvy.2 uc009cvy.3 Membrane; Multi-pass membrane protein. Ubiquitous, with higher levels in heart, brain, lung, liver and kidney. Induced during adipocytes differentiation and in white fat from aged and diabetics mice. Belongs to the UPF0359 family. Sequence=AAD15788.1; Type=Frameshift; Evidence=; plasma membrane membrane integral component of membrane embryonic cleavage negative regulation of mitotic cell cycle phase transition uc009cvy.1 uc009cvy.2 uc009cvy.3 
ENSMUST00000055032.14 Kdm5d ENSMUST00000055032.14 lysine demethylase 5D (from RefSeq NM_011419.4) ENSMUST00000055032.1 ENSMUST00000055032.10 ENSMUST00000055032.11 ENSMUST00000055032.12 ENSMUST00000055032.13 ENSMUST00000055032.2 ENSMUST00000055032.3 ENSMUST00000055032.4 ENSMUST00000055032.5 ENSMUST00000055032.6 ENSMUST00000055032.7 ENSMUST00000055032.8 ENSMUST00000055032.9 Hya Jarid1d KDM5D_MOUSE NM_011419 Q3US03 Q62240 Q6PCX3 Q9QVR9 Q9R040 Smcy uc009uzb.1 uc009uzb.2 uc009uzb.3 Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks (By similarity). Reaction=3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)- [histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate; Xref=Rhea:RHEA:60208, Rhea:RHEA-COMP:15537, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61961; EC=1.14.11.67; Evidence=; Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Interacts withPCGF6, MSH5, ZMYND8, AR. Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q62240-1; Sequence=Displayed; Name=2; IsoId=Q62240-2; Sequence=VSP_026412; Name=3; IsoId=Q62240-3; Sequence=VSP_026413, VSP_026414; Name=4; IsoId=Q62240-4; Sequence=VSP_026415, VSP_026416; The JmjC domain is required for enzymatic activity. KDM5D encodes an H-Y epitope that is defined by the octamer peptide TENSGKDI; since no similar peptide was found in KDM5C, it is presumably the genetic basis for the antigenic difference between males and females that contributes toward a tissue transplant rejection response. [Isoform 3]: May be due to an intron retention. [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the JARID1 histone demethylase family. fibrillar center T cell antigen processing and presentation DNA binding nucleus chromatin organization chromatin remodeling oxidoreductase activity histone demethylase activity histone demethylase activity (H3-K4 specific) histone demethylase activity (H3-trimethyl-K4 specific) histone H3-K4 demethylation histone H3-K4 demethylation, trimethyl-H3-K4-specific histone methyltransferase complex metal ion binding androgen receptor binding dioxygenase activity oxidation-reduction process regulation of androgen receptor signaling pathway uc009uzb.1 uc009uzb.2 uc009uzb.3 
ENSMUST00000055036.7 Cimap1c ENSMUST00000055036.7 ciliary microtubule associated protein 1C, transcript variant 2 (from RefSeq NM_198673.2) CIMAP1C CMA1C_MOUSE ENSMUST00000055036.1 ENSMUST00000055036.2 ENSMUST00000055036.3 ENSMUST00000055036.4 ENSMUST00000055036.5 ENSMUST00000055036.6 NM_198673 Odf3l1 Q810P2 uc009ptj.1 uc009ptj.2 Belongs to the CIMAP family. molecular_function cellular_component biological_process uc009ptj.1 uc009ptj.2 
ENSMUST00000055040.13 Ccdc69 ENSMUST00000055040.13 coiled-coil domain containing 69 (from RefSeq NM_177471.4) CCD69_MOUSE D11Ertd461e ENSMUST00000055040.1 ENSMUST00000055040.10 ENSMUST00000055040.11 ENSMUST00000055040.12 ENSMUST00000055040.2 ENSMUST00000055040.3 ENSMUST00000055040.4 ENSMUST00000055040.5 ENSMUST00000055040.6 ENSMUST00000055040.7 ENSMUST00000055040.8 ENSMUST00000055040.9 NM_177471 Q3TCJ8 Q8C515 uc007iyu.1 uc007iyu.2 uc007iyu.3 May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone. Cytoplasm, cytoskeleton, spindle Midbody Note=During early anaphase, localizes along overlapping interpolar microtubules between the separating chromosomes. During late anaphase, localizes to the center of spindle midzone. Concentrated at the midbody during telophase. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TCJ8-1; Sequence=Displayed; Name=2; IsoId=Q3TCJ8-2; Sequence=VSP_032858; Belongs to the CCDC69 family. nucleus cytoplasm spindle cytoskeleton microtubule binding biological_process midbody spindle midzone spindle midzone assembly microtubule cytoskeleton uc007iyu.1 uc007iyu.2 uc007iyu.3 
ENSMUST00000055052.6 Ces2c ENSMUST00000055052.6 carboxylesterase 2C (from RefSeq NM_145603.2) Ces2 Ces2c ENSMUST00000055052.1 ENSMUST00000055052.2 ENSMUST00000055052.3 ENSMUST00000055052.4 ENSMUST00000055052.5 EST2C_MOUSE NM_145603 Q91WG0 uc009nbe.1 uc009nbe.2 uc009nbe.3 uc009nbe.4 This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. The transcription of this gene is regulated by several factors including HNF-4alpha (hepatocyte nuclear factor-4alpha), Sp1 (specificity protein 1), Sp3 and USF1 (upstream stimulatory factor 1). The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with several family members including a few of pseudogenes and Ces5 on chromosome 8.[provided by RefSeq, Jun 2010]. ##Evidence-Data-START## Transcript exon combination :: AB110073.1, AK136411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Hydrolase with high activity towards palmitoylcarnitine. Is also active with p-nitrophenylacetate and alpha-naphthylacetate. May also hydrolyze retinyl esters (By similarity). Reaction=H2O + O-acyl-(R)-carnitine = (R)-carnitine + a fatty acid + H(+); Xref=Rhea:RHEA:17101, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16347, ChEBI:CHEBI:28868, ChEBI:CHEBI:75659; EC=3.1.1.28; Evidence=; Reaction=all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate; Xref=Rhea:RHEA:13933, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13934; Evidence=; Kinetic parameters: KM=98.8 uM for palmitoyl-dl-carnitine; KM=392 uM for p-nitrophenylacetate; Vmax=1.67 umol/min/mg enzyme with palmitoyl-dl-carnitine; Vmax=353 umol/min/mg enzyme with p-nitrophenylacetate; Microsome Endoplasmic reticulum Detected in liver (at protein level). Up-regulated in liver by di-(2-ethylhexyl)phtalate (DEHP). Belongs to the type-B carboxylesterase/lipase family. extracellular space endoplasmic reticulum hydrolase activity intracellular membrane-bounded organelle acylcarnitine hydrolase activity carboxylic ester hydrolase activity uc009nbe.1 uc009nbe.2 uc009nbe.3 uc009nbe.4 
ENSMUST00000055064.8 Kcna10 ENSMUST00000055064.8 potassium voltage-gated channel, shaker-related subfamily, member 10 (from RefSeq NM_001081140.1) B2RQA1 B2RXZ4 ENSMUST00000055064.1 ENSMUST00000055064.2 ENSMUST00000055064.3 ENSMUST00000055064.4 ENSMUST00000055064.5 ENSMUST00000055064.6 ENSMUST00000055064.7 KCA10_MOUSE Kcna10 NM_001081140 uc008qwt.1 uc008qwt.2 uc008qwt.3 Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP. Membrane ; Multi-pass membrane protein Expressed strongly in the inner ear and weakly in skeletal muscle. Not detected in other tissues. Detected in the cochlear duct from 14.5 dpc (PubMed:22446089). Detected in the organ of Corti and the vestibular system from 16.5 dpc onwards, where it is most strongly expressed in hair cells (PubMed:22446089, PubMed:23528307). The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Viable with no gross defects. Vestibular evoked potentials (VsEPs) are highly abnormal suggesting impaired function of the balance organ, although mice do not display any obvious imbalance behaviors. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane regulation of ion transmembrane transport protein homooligomerization transmembrane transport potassium ion transmembrane transport uc008qwt.1 uc008qwt.2 uc008qwt.3 
ENSMUST00000055071.9 Ifi27l2a ENSMUST00000055071.9 interferon, alpha-inducible protein 27 like 2A, transcript variant 1 (from RefSeq NM_029803.3) ENSMUST00000055071.1 ENSMUST00000055071.2 ENSMUST00000055071.3 ENSMUST00000055071.4 ENSMUST00000055071.5 ENSMUST00000055071.6 ENSMUST00000055071.7 ENSMUST00000055071.8 IF27A_MOUSE Ifi27 Ifi27l2a Isg12 NM_029803 Q8R412 uc007ovu.1 uc007ovu.2 uc007ovu.3 uc007ovu.4 uc007ovu.5 May be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). Through the regulation of NR4A1 transcriptional activity, may play a role in the vascular response to injury (PubMed:22427340). Homodimer (By similarity). Interacts with SKP2 (By similarity). Interacts with NR4A1 (By similarity). May interact with BCL2 (By similarity). Nucleus inner membrane ; Multi-pass membrane protein Up-regulated by interferon (PubMed:22427340). Up-regulated by vascular tissues injury (PubMed:22427340). Homozygous knockout mice exhibit no obvious phenotype, having normal growth rates, survival, fertility and litter sizes (PubMed:22427340). No organ pathology is detected (PubMed:22427340). However, they display decreased restenosis, the narrowing of blood vessels, upon vascular injury (PubMed:22427340). Belongs to the IFI6/IFI27 family. molecular_function nucleus nuclear inner membrane mitochondrion aging response to virus membrane integral component of membrane uc007ovu.1 uc007ovu.2 uc007ovu.3 uc007ovu.4 uc007ovu.5 
ENSMUST00000055077.7 Palm3 ENSMUST00000055077.7 paralemmin 3 (from RefSeq NM_028877.2) A2TJV2 ENSMUST00000055077.1 ENSMUST00000055077.2 ENSMUST00000055077.3 ENSMUST00000055077.4 ENSMUST00000055077.5 ENSMUST00000055077.6 NM_028877 PALM3_MOUSE Q9CRS0 uc009mlq.1 uc009mlq.2 uc009mlq.3 ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. Interacts with SIGIRR. Cytoplasm Cell membrane ; Lipid-anchor Palmitoylated on Cys-728 and Cys-730 and prenylated on Cys-731; which is required for membrane association. Belongs to the paralemmin family. Sequence=BAB29393.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB29393.3; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; nucleotide binding negative regulation of cytokine-mediated signaling pathway molecular_function ATP binding cellular_component cytoplasm plasma membrane Toll signaling pathway membrane response to lipopolysaccharide uc009mlq.1 uc009mlq.2 uc009mlq.3 
ENSMUST00000055083.4 Hcrt ENSMUST00000055083.4 hypocretin (from RefSeq NM_010410.2) ENSMUST00000055083.1 ENSMUST00000055083.2 ENSMUST00000055083.3 Hcrt NM_010410 Q547R2 Q547R2_MOUSE uc007lmg.1 uc007lmg.2 uc007lmg.3 This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors Hcrtr1 and Hcrtr2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF019566.1, CD769124.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Rough endoplasmic reticulum Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. Belongs to the orexin family. temperature homeostasis neuropeptide hormone activity cytoplasm endoplasmic reticulum rough endoplasmic reticulum phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration protein kinase C-activating G-protein coupled receptor signaling pathway neuropeptide signaling pathway feeding behavior negative regulation of DNA replication secretory granule type 1 hypocretin receptor binding type 2 hypocretin receptor binding eating behavior negative regulation of potassium ion transport regulation of neurotransmitter secretion positive regulation of calcium ion transport negative regulation of transmission of nerve impulse positive regulation of transmission of nerve impulse excitatory postsynaptic potential postsynapse uc007lmg.1 uc007lmg.2 uc007lmg.3 
ENSMUST00000055085.8 Tmem86b ENSMUST00000055085.8 transmembrane protein 86B (from RefSeq NM_023440.3) ENSMUST00000055085.1 ENSMUST00000055085.2 ENSMUST00000055085.3 ENSMUST00000055085.4 ENSMUST00000055085.5 ENSMUST00000055085.6 ENSMUST00000055085.7 NM_023440 Q497J1 TM86B_MOUSE uc009eya.1 uc009eya.2 Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen. Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3- saturated aldehyde + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:22544, ChEBI:CHEBI:15377, ChEBI:CHEBI:16870, ChEBI:CHEBI:73359, ChEBI:CHEBI:77287; EC=3.3.2.2; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:16905, ChEBI:CHEBI:15377, ChEBI:CHEBI:73359, ChEBI:CHEBI:77288, ChEBI:CHEBI:143890; EC=3.3.2.2; Evidence=; Competitively inhibited by lysophosphatidic acid. Homodimer. Endoplasmic reticulum membrane ; Multi-pass membrane protein Cytoplasm Enriched in liver. Also detected in brain and testis. Expressed in embryo. Belongs to the TMEM86 family. cytoplasm membrane integral component of membrane hydrolase activity ether lipid metabolic process alkenylglycerophosphocholine hydrolase activity alkenylglycerophosphoethanolamine hydrolase activity uc009eya.1 uc009eya.2 
ENSMUST00000055096.5 Ttc12 ENSMUST00000055096.5 tetratricopeptide repeat domain 12 (from RefSeq NM_172770.3) ENSMUST00000055096.1 ENSMUST00000055096.2 ENSMUST00000055096.3 ENSMUST00000055096.4 NM_172770 Q8BW49 TTC12_MOUSE uc009pjc.1 uc009pjc.2 uc009pjc.3 Cytoplasmic protein that plays a role in the proper assembly of dynein arm complexes in motile cilia in both respiratory cells and sperm flagella. Cytoplasm molecular_function centrosome biological_process uc009pjc.1 uc009pjc.2 uc009pjc.3 
ENSMUST00000055097.11 Cyren ENSMUST00000055097.11 cell cycle regulator of NHEJ, transcript variant 1 (from RefSeq NM_199145.2) CYREN_MOUSE Cyren ENSMUST00000055097.1 ENSMUST00000055097.10 ENSMUST00000055097.2 ENSMUST00000055097.3 ENSMUST00000055097.4 ENSMUST00000055097.5 ENSMUST00000055097.6 ENSMUST00000055097.7 ENSMUST00000055097.8 ENSMUST00000055097.9 Mri NM_199145 Q8BHZ5 Q8K0Y5 uc009bhw.1 uc009bhw.2 uc009bhw.3 uc009bhw.4 Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase (PubMed:30017584). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (By similarity). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (By similarity). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70 (By similarity). In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin (PubMed:30017584). Also involved in immunoglobulin V(D)J recombination (PubMed:30017584, PubMed:31795137). May also act as an indirect regulator of proteasome (By similarity). Interacts (via KBM motif) with XRCC5/Ku80 and XRCC6/Ku70 heterodimer (PubMed:30017584). Interacts (via XLF motif) with TRIM28/KAP1, ATM, MRE11, NBN and RAD50 (PubMed:30017584). Cytoplasm Nucleus Chromosome Note=Nuclear localization may depend upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer (By similarity). Localizes to DNA damage sites (PubMed:30017584). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BHZ5-1; Sequence=Displayed; Name=2; IsoId=Q8BHZ5-2; Sequence=VSP_031769; The KBM (Ku-binding motif) mediates interaction with XRCC5/Ku80 and XRCC6/Ku70 and recruitment to DNA damage sites. The XLM (XLF-like motif) mediates interaction with DNA damage response proteins TRIM28/KAP1, ATM and members of the MRN complex (MRE11, NBN and RAD50). No visible phenotype in normal conditions: mice are fertile, do not show any gross abnormalities and do not develop spontaneous cancers (PubMed:30017584, PubMed:31795137). Mice have normal numbers of B- and T-cells, but show defects in class switch recombination in primary B-cells (PubMed:30017584, PubMed:31795137). Mice lacking both Cyren and Nhej1/Xlf show embryonic lethality caused by severe defects in classical non-homologous end joining (NHEJ) (PubMed:30017584). molecular_function nucleus cytoplasm DNA repair double-strand break repair via nonhomologous end joining cellular response to DNA damage stimulus negative regulation of double-strand break repair via nonhomologous end joining uc009bhw.1 uc009bhw.2 uc009bhw.3 uc009bhw.4 
ENSMUST00000055102.13 Timd2 ENSMUST00000055102.13 T cell immunoglobulin and mucin domain containing 2, transcript variant 2 (from RefSeq NM_134249.5) A8C1R4 A8C1R4_MOUSE ENSMUST00000055102.1 ENSMUST00000055102.10 ENSMUST00000055102.11 ENSMUST00000055102.12 ENSMUST00000055102.2 ENSMUST00000055102.3 ENSMUST00000055102.4 ENSMUST00000055102.5 ENSMUST00000055102.6 ENSMUST00000055102.7 ENSMUST00000055102.8 ENSMUST00000055102.9 NM_134249 Timd2 uc007iou.1 uc007iou.2 uc007iou.3 uc007iou.4 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the immunoglobulin superfamily. TIM family. membrane integral component of membrane uc007iou.1 uc007iou.2 uc007iou.3 uc007iou.4 
ENSMUST00000055104.6 Tceal1 ENSMUST00000055104.6 transcription elongation factor A (SII)-like 1, transcript variant 1 (from RefSeq NM_146236.2) ENSMUST00000055104.1 ENSMUST00000055104.2 ENSMUST00000055104.3 ENSMUST00000055104.4 ENSMUST00000055104.5 NM_146236 Q921P9 TCAL1_MOUSE Tceal1 uc009uit.1 uc009uit.2 uc009uit.3 uc009uit.4 May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. Does not bind DNA directly (By similarity). Nucleus Belongs to the TFS-II family. TFA subfamily. protein binding nucleus nucleoplasm WW domain binding uc009uit.1 uc009uit.2 uc009uit.3 uc009uit.4 
ENSMUST00000055115.9 Vwce ENSMUST00000055115.9 von Willebrand factor C and EGF domains, transcript variant 2 (from RefSeq NR_153778.1) E9QME6 ENSMUST00000055115.1 ENSMUST00000055115.2 ENSMUST00000055115.3 ENSMUST00000055115.4 ENSMUST00000055115.5 ENSMUST00000055115.6 ENSMUST00000055115.7 ENSMUST00000055115.8 NR_153778 Q3U515 VWCE_MOUSE uc008gqo.1 uc008gqo.2 uc008gqo.3 uc008gqo.4 May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma. Secreted calcium ion binding extracellular region cytoplasm biological_process cellular response to virus uc008gqo.1 uc008gqo.2 uc008gqo.3 uc008gqo.4 
ENSMUST00000055117.9 Lemd2 ENSMUST00000055117.9 LEM domain containing 2 (from RefSeq NM_146075.2) ENSMUST00000055117.1 ENSMUST00000055117.2 ENSMUST00000055117.3 ENSMUST00000055117.4 ENSMUST00000055117.5 ENSMUST00000055117.6 ENSMUST00000055117.7 ENSMUST00000055117.8 LEMD2_MOUSE Lem2 NM_146075 Q6DVA0 Q8C4H8 Q8R0N2 uc008bfm.1 uc008bfm.2 uc008bfm.3 uc008bfm.4 uc008bfm.5 Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization and maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (By similarity). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (By similarity). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (By similarity). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (PubMed:36377660). Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT (PubMed:25790465). Required for myoblast differentiation involving regulation of ERK signaling (PubMed:17062158, PubMed:19720741). Essential for cardiac homeostasis and proper heart function (PubMed:36377660). Interacts (via N-terminus) with LMNA isoform C (via C- terminus) (in vitro) (PubMed:16339967). Interacts (via LEM domain) with BANF1 (By similarity). Interacts (via C-terminus) with CHMP7 (By similarity). Interacts (via N-terminus) with tubulin; the interaction causes microtubule bundling and stabilization (in vitro) (By similarity). Nucleus inner membrane ; Multi-pass membrane protein Nucleus envelope Cytoplasm, cytoskeleton, spindle Note=Lamina-associated protein residing in the inner nuclear membrane (INM) of the nuclear envelope (NE) (PubMed:16339967). The localization to the INM is dependent on LMNA (By similarity). Evenly distributed around the NE during interphase (PubMed:16339967). During metaphase, found in a reticular network (By similarity). Recruited to the reforming NE on chromatin disks in early anaphase (By similarity). In late anaphase, concentrates at the NE core proximal to spindle microtubules, and then broadening to a distributed nuclear rim pattern (By similarity). Ubiquitously expressed, including liver, brain, heart, skeletal muscle, lung, testis, spleen, kidney and white adipose tissue. Expressed at detectable levels throughout later stages of mouse development such as 12 dpc, 14 dpc, 16 dpc and 18 dpc. The LEM domain is required for inner nuclear membrane (INM) localization and contains a BANF1 conserved binding motif which allows localization to chromatin (By similarity). In late anaphase, as the reforming nuclear envelope (NE) surrounds the chromatin disk, both the LEM domain and the disordered regions are necessary for localization to the NE core (By similarity). The disordered regions, also named low complexity domain, confer the ability to phase separate (By similarity). In late anaphase, as the reforming nuclear envelope (NE) surrounds the chromatin disks, both the LEM domain and the disordered regions are necessary for localization to the NE core (By similarity). During NE reformation, the proline-arginine-rich sequence within the disordered region binds microtubules, targeting LEM2 condensation to spindle microtubules traversing the nascent NE (By similarity). The winged-helix (WH) region (residues 403-511) activates the ESCRT-II/ESCRT-III hybrid protein, CHMP7, to form co-oligomeric rings around spindle microtubules to facilitate early nuclear sealing. Phosphorylated; strongly phosphorylated in mitosis compared to G1/S. Embryonic lethal by 11.5 dpc (PubMed:25790465). At 10.5 dpc most tissues are substantially reduced in size, specifically neural and heart structures are developmentally less advanced and/or abnormal (PubMed:25790465). At 10.5 dpc hyperactive MAPK and AKT signaling has been observed (PubMed:25790465). Heart- specific knockout mice exhibit a reduction in body size and die shortly after birth due to heart abnormalities (PubMed:36377660). During transthoracic echocardiography, reduction in both ejection fraction (EF) and fractional shortening (FS) (PubMed:36377660). Systolic dysfunction with severely impaired contraction of the left ventricle (PubMed:36377660). Increase in nuclear envelope deformations, DNA damage, and cellular apoptosis in the heart under mechanical stress (PubMed:36377660). Sequence=AAH26588.1; Type=Erroneous initiation; Evidence=; Sequence=BAC38419.1; Type=Frameshift; Evidence=; chromatin nucleus nuclear envelope nuclear inner membrane integral component of nuclear inner membrane endoplasmic reticulum nuclear envelope organization membrane integral component of membrane neurogenesis negative regulation of BMP signaling pathway nuclear membrane skeletal muscle cell differentiation negative regulation of MAPK cascade negative regulation of protein kinase B signaling heart formation protein localization to chromatin regulation of intracellular signal transduction uc008bfm.1 uc008bfm.2 uc008bfm.3 uc008bfm.4 uc008bfm.5 
ENSMUST00000055121.7 Krtap4-7 ENSMUST00000055121.7 keratin associated protein 4-7 (from RefSeq NM_029613.1) ENSMUST00000055121.1 ENSMUST00000055121.2 ENSMUST00000055121.3 ENSMUST00000055121.4 ENSMUST00000055121.5 ENSMUST00000055121.6 Krtap4-7 NM_029613 Q9D732 Q9D732_MOUSE uc007ljj.1 uc007ljj.2 uc007ljj.3 molecular_function cellular_component intermediate filament biological_process keratin filament uc007ljj.1 uc007ljj.2 uc007ljj.3 
ENSMUST00000055125.5 Diras1 ENSMUST00000055125.5 DIRAS family, GTP-binding RAS-like 1 (from RefSeq NM_145217.2) DIRA1_MOUSE ENSMUST00000055125.1 ENSMUST00000055125.2 ENSMUST00000055125.3 ENSMUST00000055125.4 Gbts1 NM_145217 Q91Z61 uc007gfo.1 uc007gfo.2 uc007gfo.3 Displays low GTPase activity and exists predominantly in the GTP-bound form. Cell membrane ; Lipid-anchor ; Cytoplasmic side Belongs to the small GTPase superfamily. Di-Ras family. nucleotide binding GTPase activity GTP binding plasma membrane signal transduction membrane GDP binding uc007gfo.1 uc007gfo.2 uc007gfo.3 
ENSMUST00000055128.12 Tapt1 ENSMUST00000055128.12 transmembrane anterior posterior transformation 1 (from RefSeq NM_173764.3) ENSMUST00000055128.1 ENSMUST00000055128.10 ENSMUST00000055128.11 ENSMUST00000055128.2 ENSMUST00000055128.3 ENSMUST00000055128.4 ENSMUST00000055128.5 ENSMUST00000055128.6 ENSMUST00000055128.7 ENSMUST00000055128.8 ENSMUST00000055128.9 NM_173764 Q4VBD2 Q8CDI4 TAPT1_MOUSE uc008xin.1 uc008xin.2 uc008xin.3 uc008xin.4 Plays a role in primary cilia formation (By similarity). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body Membrane ; Multi-pass membrane protein Ubiquitous. Expressed throughout embryo. Mice die during perinatal development and are the cause of the L5Jcs1 phenotype. They exhibit posterior-to-anterior transformations of the vertebral column midsection, similar to mice deficient for Hoxc8 and Hoxc9. Belongs to the TAPT1 family. ossification in utero embryonic development molecular_function cytoplasm endoplasmic reticulum centrosome microtubule organizing center cytoskeleton cilium multicellular organism development post-embryonic development neural crest cell development membrane integral component of membrane cell projection organization cell differentiation integral component of endoplasmic reticulum membrane maintenance of protein localization in endoplasmic reticulum ciliary basal body cell projection positive regulation of cilium assembly embryonic skeletal system development cartilage development positive regulation of cartilage development positive regulation of bone development uc008xin.1 uc008xin.2 uc008xin.3 uc008xin.4 
ENSMUST00000055156.5 Catsperb ENSMUST00000055156.5 cation channel sperm associated auxiliary subunit beta (from RefSeq NM_173023.2) A2RTF1 CTSRB_MOUSE Catsperb ENSMUST00000055156.1 ENSMUST00000055156.2 ENSMUST00000055156.3 ENSMUST00000055156.4 NM_173023 Q8C0R2 uc007otl.1 uc007otl.2 uc007otl.3 Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation (PubMed:34225353, PubMed:17478420). Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (PubMed:17478420). Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG2, CATSPERD, CATSPERE, CATSPERZ, C2CD6/CATSPERT, SLCO6C1, TMEM249, TMEM262 and EFCAB9 (PubMed:34225353, PubMed:21224844, PubMed:17478420, PubMed:19516020, PubMed:34998468). HSPA1 may be an additional auxiliary complex member (PubMed:17478420, PubMed:19516020). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (PubMed:34225353). The auxiliary CATSPERB, CATSPERG2, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively (PubMed:34225353). SLCO6C1 interacts with CATSPERE and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex (PubMed:34225353). C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane (PubMed:34998468). Cell projection, cilium, flagellum membrane ; Single-pass membrane protein Note=Predominantly located in the principal piece of the sperm tail. Testis-specific. Specifically present in the principal piece of sperm tail (at protein level). Specifically expressed in the seminiferous tubules but not in the interstitial cells. Within the tubules, it is expressed in spermatocytes and spermatids, but not in spermatogonia. CatSperb is absent in sperm from mice lacking CatSper1, suggesting that stable expression of CatSperb protein requires CatSper1. protein binding cilium multicellular organism development spermatogenesis membrane integral component of membrane cell differentiation ion channel complex CatSper complex sperm capacitation uc007otl.1 uc007otl.2 uc007otl.3 
ENSMUST00000055159.8 Arl11 ENSMUST00000055159.8 ADP-ribosylation factor-like 11 (from RefSeq NM_177337.3) ARL11_MOUSE ENSMUST00000055159.1 ENSMUST00000055159.2 ENSMUST00000055159.3 ENSMUST00000055159.4 ENSMUST00000055159.5 ENSMUST00000055159.6 ENSMUST00000055159.7 NM_177337 Q6P3A9 Q8C7K1 uc007ufu.1 uc007ufu.2 May play a role in apoptosis. May act as a tumor suppressor (By similarity). Belongs to the small GTPase superfamily. Arf family. nucleotide binding hematopoietic progenitor cell differentiation GTP binding cytoplasm plasma membrane intracellular protein transport vesicle-mediated transport uc007ufu.1 uc007ufu.2 
ENSMUST00000055168.5 Kcna1 ENSMUST00000055168.5 potassium voltage-gated channel, shaker-related subfamily, member 1 (from RefSeq NM_010595.3) ENSMUST00000055168.1 ENSMUST00000055168.2 ENSMUST00000055168.3 ENSMUST00000055168.4 KCNA1_MOUSE Kcna1 NM_010595 P16388 uc033iva.1 uc033iva.2 uc033iva.3 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:9736643, PubMed:9581771, PubMed:10191303, PubMed:12611922, PubMed:21966978, PubMed:22158511, PubMed:23473320). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15361858). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:15361858). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed- rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:7517498, PubMed:15361858). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (By similarity). Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability (PubMed:23466697). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (By similarity). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (PubMed:20392939, PubMed:22641786, PubMed:25377007). Required for normal neuromuscular responses (PubMed:9736643). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (PubMed:23473320). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (PubMed:21966978, PubMed:22396426). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (PubMed:21233214). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (PubMed:8995755, PubMed:17250763, PubMed:17315199, PubMed:22411008). Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (By similarity). Reaction=K(+)(in) = K(+)(out); Xref=Rhea:RHEA:29463, ChEBI:CHEBI:29103; Evidence= Inhibited by 4-aminopyridine (4-AP), tetraethylammonium (TEA) and dendrotoxin (DTX), but not by charybdotoxin (CTX). Homotetramer and heterotetramer with other channel-forming alpha subunits, such as KCNA2, KCNA4, KCNA5, KCNA6 and KCNA7 (PubMed:8361541). Channel activity is regulated by interaction with the beta subunits KCNAB1 and KCNAB2 (PubMed:15361858). Identified in a complex with KCNA2 and KCNAB2. Interacts (via C-terminus) with the PDZ domains of DLG1, DLG2 and DLG4 (By similarity). Interacts with LGI1 within a complex containing LGI1, KCNA4 and KCNAB1 (By similarity). Interacts (via N-terminus) with STX1A; this promotes channel inactivation (By similarity). Interacts (via N-terminus) with the heterodimer formed by GNB1 and GNG2; this promotes channel inactivation (By similarity). Can interact simultaneously with STX1A and the heterodimer formed by GNB1 and GNG2 (By similarity). Interacts (via cytoplasmic N-terminal domain) with KCNRG; this inhibits channel activity (By similarity). Interacts with ANK3; this inhibits channel activity (PubMed:23903368). Interacts with ADAM11 (PubMed:26269648). Cell membrane ulti-pass membrane protein Cell projection, axon mbrane Perikaryon ll projection, dendrite Cell junction Synapse Cytoplasmic vesicle Endoplasmic reticulum Presynaptic cell membrane Presynapse Note=Homotetrameric KCNA1 is primarily located in the endoplasmic reticulum. Interaction with KCNA2 and KCNAB2 or with KCNA4 and KCNAB2 promotes expression at the cell membrane (By similarity). Detected in brain (PubMed:2451788, PubMed:9581771, PubMed:21483673, PubMed:22158511). Expressed in cerebellar cortex basket cell terminals, the area surround the Purkinje cell soma, and the pinceaux expansions encircling the axon initial segment (at protein level) (PubMed:26269648). Detected in the juxtaparanodal regions of the nodes of Ranvier in myelinated axons (PubMed:8361541, PubMed:8046438). Detected in the paranodal region in sciatic nerve (PubMed:9736643). Detected on cell bodies in cerebellum, dorsal and ventral cochlear nucleus, pontine reticular nucleus, mesencephalic trigeminal nucleus, motor trigeminal nucleus and the pricipal sensory trigeminal nucleus (PubMed:8046438). Detected in terminal fields of basket cells in the cerebellum corpus medullare (PubMed:8361541, PubMed:8046438, PubMed:9581771). Detected in hippocampus CA3 pyramidal neurons and in the hilus and stratum moleculare of the dentate gyrus (PubMed:8046438, PubMed:9581771, PubMed:14686897). Detected in the central nucleus and the external nucleus of the inferior colliculus (PubMed:8046438, PubMed:21966978). Detected in fiber tracts in the optic tract, external medullary lamina, stria terminalis, medulla, ventral pallidum and substantia nigra (PubMed:8046438). Detected in neurons from dorsal root ganglion (PubMed:23473320). Detected in neurons in the medial nucleus of the trapezoid body (PubMed:12611922). Detected in midbrain dopamine neuron axon terminals (PubMed:21233214). Detected in brain cortex (PubMed:8046438, PubMed:14686897). Detected in brainstem (PubMed:8361541). Detected in juxtaparanodal regions of the nodes of Ranvier in the vagus nerve, but only at very low levels in the heart (PubMed:20392939, PubMed:22641786). Detected in the islet of Langerhans (PubMed:21483673). Detected at the luminal membrane in distal convoluted tubules in the kidney (at protein level) (PubMed:19307729). Detected in hippocampus, thalamus, neocortex and ventral brain cortex, including the piriform and entorhinal cortex and the amygdala (PubMed:14686897). Detected in midbrain dopamine neurons (PubMed:21233214). Detected in heart atrium, ventricle, sinoatrial node and atrioventricular node (PubMed:20392939). Down-regulated by high dietary Mg(2+) levels. The cytoplasmic N-terminus is important for tetramerization and for interaction with the beta subunits that promote rapid channel closure. The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. N-glycosylated. Palmitoylated on Cys-243; which may be required for membrane targeting. Phosphorylated on tyrosine residues. Phosphorylation increases in response to NRG1; this inhibits channel activity (PubMed:22158511). Phosphorylation at Ser-446 regulates channel activity by down- regulating expression at the cell membrane (By similarity). Modified_positions=400 ; Note=Partially edited. RNA editing varies from 35% in the frontal cortex to 75% in the spinal chord.; Note=A spontaneous mutation leading to a frameshift and truncation of Kcna2 causes megencephaly with a 25% increase of brain weight relative to wild-type. Especially the hippocampus shows increased proliferation of neurons and astrocytes, leading to increased brain volume (PubMed:17315199). Mutant mice appear normal at birth. After 3-4 weeks, they display low body weight, a subtle shakiness in their gait, a preference for a strange sitting position that is maintained for periods ranging from 30 seconds to several minutes, excessive lacrimation and acoustic startle hypersensitivity (PubMed:8995755, PubMed:21966978). The increase in the acoustic startle response is down-regulated by treatment with the anti-epileptic drug valproate (PubMed:21966978). Mutant mice display an abnormal electro- encephalogram with single spikes and waves, when anesthesized (PubMed:21966978). The electric activity of mossy cells from the dentate hilus region is altered and shows increased firing of action potentials, probably due to the absence of functional Kcna1 channels (PubMed:14686897). Heterozygotes show mechanical allodynia, but no increased sensitivity to heat (PubMed:23473320). Homozygotes show no alteration of the islet of Langerhans structure, of the basal levels of insulin secretion and blood glucose levels (PubMed:21483673). Compared to wild-type, they display moderately increased insulin secretion in response to a glucose stimulus (PubMed:21483673). Besides, the frequency of beta cell action potentials is increased (PubMed:21483673). Mice are born at the expected Mendelian rate. After three weeks, mice begin to display episodic eye blinking, twitching of whiskers, forlimb padding, arrested motion and a hyperstartle response. About 50% of the homozygotes die between the third and the fifth week after birth. Surviving mice continue to display spontaneous seizures occurring once or twice every hour throughout adult life (PubMed:9581771). The fecundity of homozygotes is extremely low (PubMed:9581771). Mutant mice display interictal cardiac abnormalities, including a fivefold increase in atrioventricular conduction blocks, brachycardia and premature ventricular contractions; this may lead to sudden unexplained death in epilepsy (PubMed:20392939). Mutant mice have slightly elevated heart rates; they all have a reduced livespan and are subject to sudden death after presumed seizure activity and sinus bradycardia (PubMed:25377007). About 70% of the mutant mice have an enlarged hippocampus and ventral brain cortex (PubMed:17250763). Mutant mice show a temperature- sensitive alteration in neuromuscular transmission, causing nerve hyperexcitability when exposed to cold and delayed repetitive discharge after a single nerve stimulation (PubMed:9736643). After 2 minutes of swimming in cold water, mutant mice have impaired motor control; they fall over when placed on dry ground and exhibit severe neuromyotonia with violent tremors that decrease with time, leading to full recovery after twenty minutes (PubMed:9736643). Mutant mice have an increased frequency of spontaneous postsynaptic currents in Purkinje cells, impaired ability to maintain their balance on a thin stationary rod, but perform as well as wild-type on a rotarod (PubMed:10191303). Mutant mice have a normal hearing threshold, but altered brainstem responses to auditory stimuli and reduced sensitivity to small changes in sound location (PubMed:22396426). Mutant mice display no alteration of the islet of Langerhans, but have reduced blood glucose levels and increased insulin secretion in response to a glucose stimulus (PubMed:21483673). The delay or D-type current observed in hippocampus pyramidal neurons is probably mediated by potassium channels containing KCNA2 plus KCNA1 or other family members. It is activated at about -50 mV, i.e. below the action potential threshold, and is characterized by slow inactivation, extremely slow recovery from inactivation, sensitivity to dendrotoxin (DTX) and to 4-aminopyridine (4-AP). Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily. startle response ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity endoplasmic reticulum cytosol plasma membrane integral component of plasma membrane ion transport potassium ion transport regulation of muscle contraction neuroblast proliferation brain development voltage-gated potassium channel complex cell surface cell communication by electrical coupling magnesium ion homeostasis membrane integral component of membrane apical plasma membrane neuronal action potential hippocampus development neuronal signal transduction cell junction axon dendrite cytoplasmic vesicle paranode region of axon cellular protein localization potassium channel complex regulation of ion transmembrane transport regulation of membrane potential presynaptic membrane cell projection neuronal cell body perikaryon axon terminus juxtaparanode region of axon calyx of Held synapse neuromuscular process detection of mechanical stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of touch protein homooligomerization transmembrane transport regulation of postsynaptic membrane potential cellular response to magnesium ion potassium ion transmembrane transport disordered domain specific binding glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane regulation of presynaptic membrane potential voltage-gated ion channel activity involved in regulation of presynaptic membrane potential positive regulation of voltage-gated potassium channel activity voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential uc033iva.1 uc033iva.2 uc033iva.3 
ENSMUST00000055184.7 Gp1ba ENSMUST00000055184.7 glycoprotein 1b, alpha polypeptide (from RefSeq NM_010326.3) ENSMUST00000055184.1 ENSMUST00000055184.2 ENSMUST00000055184.3 ENSMUST00000055184.4 ENSMUST00000055184.5 ENSMUST00000055184.6 GP1BA_MOUSE NM_010326 O35930 Q5SX47 uc007jvq.1 uc007jvq.2 uc007jvq.3 uc007jvq.4 GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage. Interacts with FLNB. Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23). Membrane; Single-pass type I membrane protein. O-glycosylated. Glycocalicin is the product of a proteolytic cleavage/shedding, catalyzed by ADAM17, which releases most of the extracellular domain. Binding sites for vWF and thrombin are in this part of the protein. Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein. cell morphogenesis extracellular space plasma membrane integral component of plasma membrane cell adhesion blood coagulation hemostasis membrane integral component of membrane extracellular matrix anchored component of external side of plasma membrane fibrinolysis platelet aggregation uc007jvq.1 uc007jvq.2 uc007jvq.3 uc007jvq.4 
ENSMUST00000055190.8 Baiap2l1 ENSMUST00000055190.8 BAI1-associated protein 2-like 1 (from RefSeq NM_025833.3) BI2L1_MOUSE ENSMUST00000055190.1 ENSMUST00000055190.2 ENSMUST00000055190.3 ENSMUST00000055190.4 ENSMUST00000055190.5 ENSMUST00000055190.6 ENSMUST00000055190.7 Irtks NM_025833 Q9DBJ3 uc009alq.1 uc009alq.2 uc009alq.3 May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity). Interacts with RAC1. Binds to F-actin. Interacts with FASLG (By similarity). Cytoplasm, cytoskeleton Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites. Detected in bladder, liver, testes, heart, lung, spleen, brain and skeletal muscle (at protein level). The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity). Phosphorylated on tyrosine in response to insulin. actin binding nucleoplasm cytoplasm cytosol cytoskeleton plasma membrane plasma membrane organization response to bacterium actin cytoskeleton regulation of actin filament polymerization positive regulation of actin filament polymerization regulation of insulin receptor signaling pathway actin filament bundle assembly actin crosslink formation proline-rich region binding positive regulation of actin cytoskeleton reorganization uc009alq.1 uc009alq.2 uc009alq.3 
ENSMUST00000055195.11 Lmbr1 ENSMUST00000055195.11 limb region 1 (from RefSeq NM_020295.3) ENSMUST00000055195.1 ENSMUST00000055195.10 ENSMUST00000055195.2 ENSMUST00000055195.3 ENSMUST00000055195.4 ENSMUST00000055195.5 ENSMUST00000055195.6 ENSMUST00000055195.7 ENSMUST00000055195.8 ENSMUST00000055195.9 LMBR1_MOUSE NM_020295 Q766D0 Q91WC6 Q9JIS9 Q9JIT0 uc008wug.1 uc008wug.2 uc008wug.3 This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660811.89872.1, AF190665.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Putative membrane receptor. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=LMBR1L; IsoId=Q9JIT0-1; Sequence=Displayed; Name=2; Synonyms=LMBR1S; IsoId=Q9JIT0-2; Sequence=VSP_016889, VSP_016890; Name=3; IsoId=Q9JIT0-3; Sequence=VSP_016891; Belongs to the LIMR family. Sequence=BAD07410.1; Type=Frameshift; Evidence=; membrane integral component of membrane embryonic hindlimb morphogenesis embryonic digit morphogenesis uc008wug.1 uc008wug.2 uc008wug.3 
ENSMUST00000055211.6 Lrrc3b ENSMUST00000055211.6 leucine rich repeat containing 3B, transcript variant 1 (from RefSeq NM_146052.5) ENSMUST00000055211.1 ENSMUST00000055211.2 ENSMUST00000055211.3 ENSMUST00000055211.4 ENSMUST00000055211.5 LRC3B_MOUSE Lrp15 NM_146052 Q8VCH9 uc007sgu.1 uc007sgu.2 uc007sgu.3 uc007sgu.4 uc007sgu.5 uc007sgu.6 Membrane ; Single-pass membrane protein Belongs to the LRRC3 family. molecular_function extracellular space biological_process membrane integral component of membrane extracellular matrix uc007sgu.1 uc007sgu.2 uc007sgu.3 uc007sgu.4 uc007sgu.5 uc007sgu.6 
ENSMUST00000055221.9 Kcnk12 ENSMUST00000055221.9 potassium channel, subfamily K, member 12 (from RefSeq NM_199251.1) ENSMUST00000055221.1 ENSMUST00000055221.2 ENSMUST00000055221.3 ENSMUST00000055221.4 ENSMUST00000055221.5 ENSMUST00000055221.6 ENSMUST00000055221.7 ENSMUST00000055221.8 Kcnk12 NM_199251 Q76M80 Q76M80_MOUSE mntk1 uc008dvc.1 uc008dvc.2 uc008dvc.3 Membrane ; Multi- pass membrane protein Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. potassium channel activity integral component of plasma membrane ion transport membrane integral component of membrane potassium ion leak channel activity stabilization of membrane potential potassium ion transmembrane transport uc008dvc.1 uc008dvc.2 uc008dvc.3 
ENSMUST00000055226.13 Fn1 ENSMUST00000055226.13 fibronectin 1, transcript variant 1 (from RefSeq NM_010233.2) ENSMUST00000055226.1 ENSMUST00000055226.10 ENSMUST00000055226.11 ENSMUST00000055226.12 ENSMUST00000055226.2 ENSMUST00000055226.3 ENSMUST00000055226.4 ENSMUST00000055226.5 ENSMUST00000055226.6 ENSMUST00000055226.7 ENSMUST00000055226.8 ENSMUST00000055226.9 FINC_MOUSE Fn1 G5E8B8 NM_010233 P11276 Q61567 Q61568 Q61569 Q64233 Q80UI4 uc007bju.1 uc007bju.2 uc007bju.3 uc007bju.4 Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (By similarity). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (PubMed:21768292). Participates in the regulation of type I collagen deposition by osteoblasts (PubMed:21768292). Acts as a ligand for the Lilrb4a receptor, inhibiting Fcgr1/CD64-mediated monocyte activation (PubMed:34089617). Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. [Anastellin]: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7 (By similarity). Interacts with COMP. Interacts (via type III repeats 9-14) with TNFAIP6 (via CUB domain); this interaction enhances fibronectin fibril assembly. TNFAIP6 may act as a bridging molecule between FN1 and THBS1 (By similarity). Interacts with TNR; the interaction inhibits cell adhesion and neurite outgrowth (By similarity). Interacts with FST3 and MYOC (By similarity). Interacts with SVEP1 (PubMed:36792666). P11276; Q8CIH5: Plcg2; NbExp=6; IntAct=EBI-641955, EBI-617954; Secreted, extracellular space, extracellular matrix Secreted Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced. The diversity of isoforms depends on the V region and either of the two extra domain which can be either included or excluded (partially or completely for the V region). ; Name=1; IsoId=P11276-1; Sequence=Displayed; Expressed in the inner limiting membrane and around blood vessels in the retina (at protein level) (PubMed:29777959). Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Glucocorticoids suppressed mRNA expression and protein synthesis. Sulfated. Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers). Phosphorylated by FAM20C in the extracellular medium. Proteolytic processing produces the C-terminal NC1 peptide, anastellin. Some lysine residues are oxidized to allysine by LOXL3, promoting fibronectin activation and matrix formation. Serotonylated on Gln residues by TGM2 in response to hypoxia. Muscle-specific mutant mice show comparable body weight, glucose tolerance test (GTT) and insulin tolerance test (ITT) with control mice. After high fat diet (HFD) feeding and exercise training, control and mutant mice have a similar body weight and liver and muscle tissue weight but daily exercise training improves GTT and ITT values in HFD-fed control mice but not in HFD-fed mutants. angiogenesis cell activation regulation of protein phosphorylation protease binding receptor binding integrin binding extracellular matrix structural constituent protein binding extracellular region fibrinogen complex basement membrane extracellular space endoplasmic reticulum-Golgi intermediate compartment acute-phase response cell-substrate junction assembly cell adhesion cell-matrix adhesion calcium-independent cell-matrix adhesion protein C-terminus binding heparin binding positive regulation of cell proliferation glial cell migration regulation of cell shape positive regulation of gene expression positive regulation of peptidase activity apical plasma membrane peptidase activator activity peptide cross-linking enzyme binding extracellular matrix organization positive regulation of cell migration extracellular matrix integrin activation substrate adhesion-dependent cell spreading endodermal cell differentiation wound healing identical protein binding negative regulation of apoptotic process proteoglycan binding mercury ion binding positive regulation of axon extension positive regulation of fibroblast proliferation positive regulation of chemotaxis chaperone binding interaction with symbiont interaction with other organism via secreted substance involved in symbiotic interaction extracellular exosome regulation of ERK1 and ERK2 cascade cellular response to mercury ion cellular response to interleukin-1 disordered domain specific binding neural crest cell migration involved in autonomic nervous system development positive regulation of substrate-dependent cell migration, cell attachment to substrate negative regulation of transforming growth factor-beta secretion uc007bju.1 uc007bju.2 uc007bju.3 uc007bju.4 
ENSMUST00000055241.13 Zfp106 ENSMUST00000055241.13 zinc finger protein 106, transcript variant 1 (from RefSeq NM_011743.4) ENSMUST00000055241.1 ENSMUST00000055241.10 ENSMUST00000055241.11 ENSMUST00000055241.12 ENSMUST00000055241.2 ENSMUST00000055241.3 ENSMUST00000055241.4 ENSMUST00000055241.5 ENSMUST00000055241.6 ENSMUST00000055241.7 ENSMUST00000055241.8 ENSMUST00000055241.9 NM_011743 R4GML0 R4GML0_MOUSE Zfp106 uc008lwc.1 uc008lwc.2 uc008lwc.3 nucleic acid binding uc008lwc.1 uc008lwc.2 uc008lwc.3 
ENSMUST00000055242.11 Clptm1 ENSMUST00000055242.11 cleft lip and palate associated transmembrane protein 1 (from RefSeq NM_019649.2) CLPT1_MOUSE ENSMUST00000055242.1 ENSMUST00000055242.10 ENSMUST00000055242.2 ENSMUST00000055242.3 ENSMUST00000055242.4 ENSMUST00000055242.5 ENSMUST00000055242.6 ENSMUST00000055242.7 ENSMUST00000055242.8 ENSMUST00000055242.9 N14 NM_019649 O08708 Q3U758 Q3U823 Q3UG77 Q8VBZ3 Q8VEJ6 uc009fmq.1 uc009fmq.2 uc009fmq.3 Involved in GABAergic but not glutamatergic transmission (PubMed:29395912). Binds and traps GABAA receptors in the endoplasmic reticulum (ER) (PubMed:29395912). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors (PubMed:29395912). Altered GABAergic signaling is one among many causes of cleft palate (PubMed:29395912). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (By similarity). May play a role in T-cell development (PubMed:9218588). Membrane ; Multi-pass membrane protein Widely expressed (PubMed:9218588, PubMed:9828125). Expressed by subcapsular and outer cortical thymic cells (PubMed:9218588). Ubiquitously expressed in mouse embryo. Mice overexpressing Clptm1 exhibit an aberrant development of thymocytes. Belongs to the CLPTM1 family. Sequence=BAA19836.1; Type=Frameshift; Evidence=; molecular_function multicellular organism development external side of plasma membrane membrane integral component of membrane cell differentiation regulation of T cell differentiation in thymus uc009fmq.1 uc009fmq.2 uc009fmq.3 
ENSMUST00000055245.13 Abraxas1 ENSMUST00000055245.13 BRCA1 A complex subunit (from RefSeq NM_172405.4) ABRX1_MOUSE Abra1 Abraxas1 Ccdc98 ENSMUST00000055245.1 ENSMUST00000055245.10 ENSMUST00000055245.11 ENSMUST00000055245.12 ENSMUST00000055245.2 ENSMUST00000055245.3 ENSMUST00000055245.4 ENSMUST00000055245.5 ENSMUST00000055245.6 ENSMUST00000055245.7 ENSMUST00000055245.8 ENSMUST00000055245.9 Fam175a NM_172405 Q3TJ88 Q8BFV6 Q8BPZ8 Q8BT69 Q8K2T7 uc008yid.1 uc008yid.2 uc008yid.3 Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the complex, interacts directly with UIMC1/RAP80, BRCC3/BRCC36 and BABAM2. Homodimer. Interacts directly (when phosphorylated at Ser-404) with BRCA1. The phosphorylated homodimer can interact directly with two BRCA1 chains, giving rise to a heterotetramer. Binds polyubiquitin. Nucleus Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BPZ8-1; Sequence=Displayed; Name=2; IsoId=Q8BPZ8-2; Sequence=VSP_023335, VSP_023336; Phosphorylation of Ser-404 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Belongs to the FAM175 family. Abraxas subfamily. Sequence=AAH29845.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC25434.1; Type=Frameshift; Evidence=; Sequence=BAE39607.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleus DNA repair double-strand break repair chromatin organization cellular response to DNA damage stimulus microtubule binding attachment of spindle microtubules to kinetochore response to ionizing radiation nuclear body polyubiquitin binding positive regulation of DNA repair BRCA1-A complex protein K63-linked deubiquitination signal transduction involved in G2 DNA damage checkpoint mitotic spindle assembly uc008yid.1 uc008yid.2 uc008yid.3 
ENSMUST00000055256.14 Ncor2 ENSMUST00000055256.14 Belongs to the N-CoR nuclear receptor corepressors family. (from UniProt E9Q701) AF113001 E9Q701 E9Q701_MOUSE ENSMUST00000055256.1 ENSMUST00000055256.10 ENSMUST00000055256.11 ENSMUST00000055256.12 ENSMUST00000055256.13 ENSMUST00000055256.2 ENSMUST00000055256.3 ENSMUST00000055256.4 ENSMUST00000055256.5 ENSMUST00000055256.6 ENSMUST00000055256.7 ENSMUST00000055256.8 ENSMUST00000055256.9 Ncor2 uc008zqx.1 uc008zqx.2 uc008zqx.3 uc008zqx.4 Belongs to the N-CoR nuclear receptor corepressors family. DNA binding nucleus uc008zqx.1 uc008zqx.2 uc008zqx.3 uc008zqx.4 
ENSMUST00000055257.7 Fam89a ENSMUST00000055257.7 family with sequence similarity 89, member A (from RefSeq NM_001081120.2) ENSMUST00000055257.1 ENSMUST00000055257.2 ENSMUST00000055257.3 ENSMUST00000055257.4 ENSMUST00000055257.5 ENSMUST00000055257.6 FA89A_MOUSE NM_001081120 Q14BJ1 Q8R3X3 uc009nxp.1 uc009nxp.2 uc009nxp.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14BJ1-1; Sequence=Displayed; Name=2; IsoId=Q14BJ1-2; Sequence=VSP_036132; Belongs to the FAM89 family. molecular_function cellular_component biological_process uc009nxp.1 uc009nxp.2 uc009nxp.3 
ENSMUST00000055261.11 Mob1a ENSMUST00000055261.11 MOB kinase activator 1A, transcript variant 1 (from RefSeq NM_145571.3) ENSMUST00000055261.1 ENSMUST00000055261.10 ENSMUST00000055261.2 ENSMUST00000055261.3 ENSMUST00000055261.4 ENSMUST00000055261.5 ENSMUST00000055261.6 ENSMUST00000055261.7 ENSMUST00000055261.8 ENSMUST00000055261.9 MOB1A_MOUSE Mobk1b Mobkl1b NM_145571 Q3TJA6 Q8C194 Q8C1C7 Q921Y0 uc009cng.1 uc009cng.2 uc009cng.3 uc009cng.4 uc009cng.5 Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity). Binds STK38 and STK38L. Interacts with LATS1 and LATS2 (By similarity). Forms a tripartite complex with STK38 and STK3/MST2 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q921Y0-1; Sequence=Displayed; Name=2; IsoId=Q921Y0-2; Sequence=VSP_012297; Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. Belongs to the MOB1/phocein family. nucleus nucleolus cytosol hippo signaling metal ion binding uc009cng.1 uc009cng.2 uc009cng.3 uc009cng.4 uc009cng.5 
ENSMUST00000055262.13 Vti1b ENSMUST00000055262.13 vesicle transport through interaction with t-SNAREs 1B, transcript variant 1 (from RefSeq NM_016800.3) ENSMUST00000055262.1 ENSMUST00000055262.10 ENSMUST00000055262.11 ENSMUST00000055262.12 ENSMUST00000055262.2 ENSMUST00000055262.3 ENSMUST00000055262.4 ENSMUST00000055262.5 ENSMUST00000055262.6 ENSMUST00000055262.7 ENSMUST00000055262.8 ENSMUST00000055262.9 NM_016800 Q91XH6 Q91XH6_MOUSE Vti1b uc007nzx.1 uc007nzx.2 uc007nzx.3 uc007nzx.4 Membrane ; Single- pass type IV membrane protein Belongs to the VTI1 family. SNARE binding lysosomal membrane Golgi apparatus cytosol intracellular protein transport membrane integral component of membrane vesicle-mediated transport chloride channel inhibitor activity early endosome membrane late endosome membrane vesicle intracellular membrane-bounded organelle perinuclear region of cytoplasm recycling endosome recycling endosome membrane regulation of protein localization to plasma membrane uc007nzx.1 uc007nzx.2 uc007nzx.3 uc007nzx.4 
ENSMUST00000055281.8 Skor1 ENSMUST00000055281.8 SKI family transcriptional corepressor 1, transcript variant 1 (from RefSeq NM_172446.3) B2RQS8 Corl1 ENSMUST00000055281.1 ENSMUST00000055281.2 ENSMUST00000055281.3 ENSMUST00000055281.4 ENSMUST00000055281.5 ENSMUST00000055281.6 ENSMUST00000055281.7 Lbxcor1 NM_172446 Q3UYA4 Q5W8I2 Q8BX46 Q8C0T2 SKOR1_MOUSE uc009qat.1 uc009qat.2 uc009qat.3 uc009qat.4 Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1. Interacts with SMAD1, SMAD2 and SMAD3 (By similarity). Interacts with LBX1. Q8BX46; P52955: Lbx1; NbExp=2; IntAct=EBI-604451, EBI-604594; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8BX46-1; Sequence=Displayed; Name=2 ; IsoId=Q8BX46-2; Sequence=VSP_014179; Expressed in brain with higher levels in embryo than adult. Expressed by migratory precursors of Purkinje cells in the postnatal brain. Also expressed in adult testis. Expressed in the developing cerebellum, pons, medulla oblongata and spinal cord. In embryonic brain, expressed in a subset of postmitotic neurons generated posterior to the midbrain- hindbrain border. In the developing spinal cord, selectively expressed in dorsal horn interneurons. Belongs to the SKI family. transcription corepressor activity protein binding nucleus transcription factor complex dendrite negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway neuronal cell body negative regulation of cell differentiation negative regulation of transcription, DNA-templated SMAD binding uc009qat.1 uc009qat.2 uc009qat.3 uc009qat.4 
ENSMUST00000055294.4 Grem2 ENSMUST00000055294.4 gremlin 2, DAN family BMP antagonist, transcript variant 1 (from RefSeq NM_011825.2) ENSMUST00000055294.1 ENSMUST00000055294.2 ENSMUST00000055294.3 Grem2 NM_011825 Q3TST1 Q3TST1_MOUSE uc007dtf.1 uc007dtf.2 Secreted Belongs to the DAN family. Lacks conserved residue(s) required for the propagation of feature annotation. cytokine activity extracellular region extracellular space signal transduction uc007dtf.1 uc007dtf.2 
ENSMUST00000055296.11 Polr1a ENSMUST00000055296.11 polymerase (RNA) I polypeptide A (from RefSeq NM_009088.3) ENSMUST00000055296.1 ENSMUST00000055296.10 ENSMUST00000055296.2 ENSMUST00000055296.3 ENSMUST00000055296.4 ENSMUST00000055296.5 ENSMUST00000055296.6 ENSMUST00000055296.7 ENSMUST00000055296.8 ENSMUST00000055296.9 NM_009088 O35134 Q7TSA9 RPA1_MOUSE Rpa1 Rpo1-4 uc009chv.1 uc009chv.2 uc009chv.3 uc009chv.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA- COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.6; Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity). Interacts with MYO1C (PubMed:16514417). Interacts with ERBB2 (By similarity). Interacts with DDX11 (By similarity). Interacts with RECQL5 (By similarity). Nucleus, nucleolus Chromosome Phosphorylated. Belongs to the RNA polymerase beta' chain family. RNA polymerase I activity DNA binding chromatin binding DNA-directed 5'-3' RNA polymerase activity protein binding nucleus nucleoplasm nucleolus DNA-directed RNA polymerase I complex transcription, DNA-templated transcription from RNA polymerase I promoter zinc ion binding rRNA transcription transferase activity nucleotidyltransferase activity metal ion binding negative regulation of protein localization to nucleolus uc009chv.1 uc009chv.2 uc009chv.3 uc009chv.4 
ENSMUST00000055303.5 Mettl6 ENSMUST00000055303.5 methyltransferase 6, methylcytidine, transcript variant 1 (from RefSeq NM_025907.4) ENSMUST00000055303.1 ENSMUST00000055303.2 ENSMUST00000055303.3 ENSMUST00000055303.4 METL6_MOUSE Mettl6 NM_025907 Q8BVH9 Q9D9M6 Q9DAX6 uc007sxq.1 uc007sxq.2 uc007sxq.3 S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU) (PubMed:28655767). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation (By similarity). Reaction=cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:50956, Rhea:RHEA-COMP:12849, Rhea:RHEA-COMP:12851, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74894, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50957; Evidence=; Monomer (By similarity). Interacts with SARS1/SerRS; interaction is mediated via tRNA(Ser) and is required for N(3)- methylcytidine methylation (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BVH9-1; Sequence=Displayed; Name=2; IsoId=Q8BVH9-2; Sequence=VSP_008481; Name=3; IsoId=Q8BVH9-3; Sequence=VSP_008482; Mice were born with normal Mendelian ratio without developmental defects (PubMed:28655767, PubMed:32923617). However, male show a significant reduction in body weight over time due to reduced energy expenditure (PubMed:32923617). Cells show reduced N(3)-methylcytidine modification in tRNA fractions (PubMed:28655767). [Isoform 2]: Due to intron retention. Belongs to the methyltransferase superfamily. METL family. tRNA C5-cytosine methylation cellular_component methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity transferase activity methylation uc007sxq.1 uc007sxq.2 uc007sxq.3 
ENSMUST00000055304.14 Pip5kl1 ENSMUST00000055304.14 phosphatidylinositol-4-phosphate 5-kinase-like 1, transcript variant 2 (from RefSeq NM_198191.3) A2ASY7 A2ASY9 ENSMUST00000055304.1 ENSMUST00000055304.10 ENSMUST00000055304.11 ENSMUST00000055304.12 ENSMUST00000055304.13 ENSMUST00000055304.2 ENSMUST00000055304.3 ENSMUST00000055304.4 ENSMUST00000055304.5 ENSMUST00000055304.6 ENSMUST00000055304.7 ENSMUST00000055304.8 ENSMUST00000055304.9 NM_198191 PI5L1_MOUSE Pipkh Q3TNU0 Q3V0C8 Q52KH3 Q6U7H8 Q8K345 uc008jfv.1 uc008jfv.2 uc008jfv.3 May act as a scaffold to localize and regulate type I phosphatidylinositol 4-phosphate 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. Interacts with type I phosphatidylinositol 4-phosphate 5- kinases, including PIP5K1A and PIP5K1B. Cytoplasm Membrane Note=Localized to large cytoplasmic vesicular structures. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6U7H8-1; Sequence=Displayed; Name=2; IsoId=Q6U7H8-2; Sequence=VSP_024905; Name=3; IsoId=Q6U7H8-3; Sequence=VSP_024906, VSP_024909; Name=4; IsoId=Q6U7H8-4; Sequence=VSP_024907, VSP_024908; Highly expressed in brain and testis, relatively to heart, spleen, lung, liver, skeletal muscle and kidney. In spite of its similarity to other phosphatidylinositol kinases, lacks intrinsic lipid kinase activity. nucleotide binding negative regulation of protein phosphorylation protein binding ATP binding cytoplasm cytosol negative regulation of mitochondrial membrane potential membrane kinase activity phosphatidylinositol phosphate kinase activity 1-phosphatidylinositol-4-phosphate 5-kinase activity phosphorylation transferase activity negative regulation of cell migration cell projection positive regulation of apoptotic process phosphatidylinositol metabolic process phosphatidylinositol phosphorylation uc008jfv.1 uc008jfv.2 uc008jfv.3 
ENSMUST00000055314.4 Teddm1b ENSMUST00000055314.4 transmembrane epididymal protein 1B (from RefSeq NM_001008426.4) EG433365 ENSMUST00000055314.1 ENSMUST00000055314.2 ENSMUST00000055314.3 Gm5531 NM_001008426 Q8CC62 Q8CC62_MOUSE Teddm1b uc007dao.1 uc007dao.2 Membrane ; Multi- pass membrane protein Belongs to the TMEM45 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007dao.1 uc007dao.2 
ENSMUST00000055316.10 Pdf ENSMUST00000055316.10 peptide deformylase (mitochondrial) (from RefSeq NM_026513.2) DEFM_MOUSE ENSMUST00000055316.1 ENSMUST00000055316.2 ENSMUST00000055316.3 ENSMUST00000055316.4 ENSMUST00000055316.5 ENSMUST00000055316.6 ENSMUST00000055316.7 ENSMUST00000055316.8 ENSMUST00000055316.9 NM_026513 Pdf S4R2K0 uc009ngx.1 uc009ngx.2 uc009ngx.3 uc009ngx.4 uc009ngx.5 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Reaction=H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N- terminal L-methionyl-[peptide]; Xref=Rhea:RHEA:24420, Rhea:RHEA- COMP:10639, Rhea:RHEA-COMP:10640, ChEBI:CHEBI:15377, ChEBI:CHEBI:15740, ChEBI:CHEBI:49298, ChEBI:CHEBI:64731; EC=3.5.1.88; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Note=Binds 1 Co(2+) ion. ; Homodimer. Mitochondrion Belongs to the polypeptide deformylase family. mitochondrion translation positive regulation of cell proliferation hydrolase activity peptidyl-methionine modification N-terminal protein amino acid modification peptide deformylase activity metal ion binding uc009ngx.1 uc009ngx.2 uc009ngx.3 uc009ngx.4 uc009ngx.5 
ENSMUST00000055322.6 Ier5 ENSMUST00000055322.6 immediate early response 5 (from RefSeq NM_010500.2) ENSMUST00000055322.1 ENSMUST00000055322.2 ENSMUST00000055322.3 ENSMUST00000055322.4 ENSMUST00000055322.5 Ier5 NM_010500 Q3UJ54 Q3UJ54_MOUSE uc007dax.1 uc007dax.2 uc007dax.3 uc007dax.4 Belongs to the IER family. protein phosphatase type 2A complex nucleus cytoplasm cellular response to heat regulation of cell proliferation identical protein binding positive regulation of transcription from RNA polymerase II promoter positive regulation of cellular response to heat uc007dax.1 uc007dax.2 uc007dax.3 uc007dax.4 
ENSMUST00000055327.8 Aqp3 ENSMUST00000055327.8 aquaporin 3 (from RefSeq NM_016689.2) AQP3_MOUSE ENSMUST00000055327.1 ENSMUST00000055327.2 ENSMUST00000055327.3 ENSMUST00000055327.4 ENSMUST00000055327.5 ENSMUST00000055327.6 ENSMUST00000055327.7 NM_016689 Q3TU75 Q8R2N1 Q9JJN8 Q9WTJ3 uc008sih.1 uc008sih.2 uc008sih.3 Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Detected in principal cells in collecting ducts in kidney medulla (at protein level) (PubMed:16641094). Renal medulla and colon. Predominantly in the inner medulla. Expressed in basal layer of epidermal keratinocytes. Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Mice have dry skin with reduced SC (stratum corneum) hydration, decreased elasticity and impaired biosynthesis. The glycerol content of SC and epidermis is reduced, whereas that of dermis and serum is normal. The dry, relatively inelastic skin is probably related to the humectant properties of glycerol, and the impaired SC repair to impaired epidermal biosynthetic function. Belongs to the MIP/aquaporin (TC 1.A.8) family. Sequence=BAB03270.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; positive regulation of immune system process nucleus cytoplasm plasma membrane integral component of plasma membrane cell-cell junction water transport urea transmembrane transporter activity water channel activity glycerol channel activity channel activity glycerol transport urea transport membrane integral component of membrane basolateral plasma membrane response to retinoic acid odontogenesis transmembrane transport renal water absorption cellular response to hypoxia urea transmembrane transport cellular response to oxygen-glucose deprivation uc008sih.1 uc008sih.2 uc008sih.3 
ENSMUST00000055341.7 Gfod1 ENSMUST00000055341.7 glucose-fructose oxidoreductase domain containing 1 (from RefSeq NM_001033399.4) B9EI39 ENSMUST00000055341.1 ENSMUST00000055341.2 ENSMUST00000055341.3 ENSMUST00000055341.4 ENSMUST00000055341.5 ENSMUST00000055341.6 GFOD1_MOUSE NM_001033399 Q3UHD2 uc007qfx.1 uc007qfx.2 uc007qfx.3 Secreted Belongs to the Gfo/Idh/MocA family. cellular_component extracellular region oxidoreductase activity oxidation-reduction process uc007qfx.1 uc007qfx.2 uc007qfx.3 
ENSMUST00000055345.9 Tmem202 ENSMUST00000055345.9 transmembrane protein 202 (from RefSeq NM_178388.2) ENSMUST00000055345.1 ENSMUST00000055345.2 ENSMUST00000055345.3 ENSMUST00000055345.4 ENSMUST00000055345.5 ENSMUST00000055345.6 ENSMUST00000055345.7 ENSMUST00000055345.8 NM_178388 Q80W35 TM202_MOUSE uc009pxv.1 uc009pxv.2 Membrane ; Multi-pass membrane protein molecular_function plasma membrane biological_process membrane integral component of membrane uc009pxv.1 uc009pxv.2 
ENSMUST00000055349.15 Zfp943 ENSMUST00000055349.15 zinc finger prtoein 943 (from RefSeq NM_001025373.2) 4930432O21Rik ENSMUST00000055349.1 ENSMUST00000055349.10 ENSMUST00000055349.11 ENSMUST00000055349.12 ENSMUST00000055349.13 ENSMUST00000055349.14 ENSMUST00000055349.2 ENSMUST00000055349.3 ENSMUST00000055349.4 ENSMUST00000055349.5 ENSMUST00000055349.6 ENSMUST00000055349.7 ENSMUST00000055349.8 ENSMUST00000055349.9 NM_001025373 Q6NZP4 Q6NZP4_MOUSE Zfp943 uc008arm.1 uc008arm.2 uc008arm.3 uc008arm.4 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008arm.1 uc008arm.2 uc008arm.3 uc008arm.4 
ENSMUST00000055352.8 Fam120b ENSMUST00000055352.8 family with sequence similarity 120, member B, transcript variant 1 (from RefSeq NM_024203.3) Ccpg ENSMUST00000055352.1 ENSMUST00000055352.2 ENSMUST00000055352.3 ENSMUST00000055352.4 ENSMUST00000055352.5 ENSMUST00000055352.6 ENSMUST00000055352.7 F120B_MOUSE Kiaa1838 NM_024203 Q5DTU5 Q6RI63 Q8BK59 Q8BVH5 Q8BWQ3 Q8C158 Q99LL4 Q9DAC3 uc008aoj.1 uc008aoj.2 uc008aoj.3 uc008aoj.4 Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation. Interacts with ESR1 and RXRA. Interacts with PPARG; in a ligand-independent manner. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6RI63-1; Sequence=Displayed; Name=2; IsoId=Q6RI63-2; Sequence=VSP_033417, VSP_033418; Ubiquitously expressed (at protein level). Expressed throughout the embryonic developmental stages from 5 dpc to 19 dpc (at protein level). Up-regulated in differentiating adipocytes (at protein level). Belongs to the constitutive coactivator of PPAR-gamma family. Sequence=AAH03200.1; Type=Erroneous initiation; Evidence=; Sequence=BAB24339.1; Type=Erroneous initiation; Evidence=; Sequence=BAD90470.1; Type=Erroneous translation; Evidence=; protein binding nucleus nucleoplasm cell differentiation peroxisome proliferator activated receptor signaling pathway fat cell differentiation uc008aoj.1 uc008aoj.2 uc008aoj.3 uc008aoj.4 
ENSMUST00000055374.8 Tssk2 ENSMUST00000055374.8 testis-specific serine kinase 2 (from RefSeq NM_009436.2) ENSMUST00000055374.1 ENSMUST00000055374.2 ENSMUST00000055374.3 ENSMUST00000055374.4 ENSMUST00000055374.5 ENSMUST00000055374.6 ENSMUST00000055374.7 NM_009436 O54863 Q6P8M9 Stk22b TSSK2_MOUSE uc007yml.1 uc007yml.2 Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-281' of TSKS and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Mg(2+) and Mn(2+) were both present in the kinase buffer but Mg(2+) is likely to be the in vivo cofactor. ; Activated by phosphorylation on Thr-174, potentially by autophosphorylation. Interacts with TSSK1B (PubMed:10781952, PubMed:18367677). Interacts with HSP90; this interaction stabilizes TSSK2 (PubMed:23599433). Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment. In spermatids, concentrates in centrioles during flagellogenesis. Localizes in the tail and acrosomal regions of epididymal sperm. Testis-specific. Expressed only in the spermatids postmeiotically at the final stages of cytodifferentiation in the seminiferous tubules (at protein level). Not detected in released sperms in the lumen of the seminiferous tubules. Also present in the epididymal sperm (at protein level). First expression detected at 3.5 to 4 weeks. Autophosphorylated. Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation. Male mice lacking Tssk1b and Tssk2 are sterile due to haploinsufficiency. chimeras show failure to form elongated spermatids, apoptosis of spermatocytes and spermatids, and the appearance of numerous round cells in the epididymal lumen. Elongating spermatids possess a collapsed mitochondrial sheath. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding magnesium ion binding acrosomal vesicle protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm centriole cytoskeleton protein phosphorylation multicellular organism development spermatogenesis spermatid development kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation cell differentiation cytoplasmic vesicle intracellular signal transduction macromolecular complex binding protein autophosphorylation metal ion binding uc007yml.1 uc007yml.2 
ENSMUST00000055375.6 Lce3c ENSMUST00000055375.6 late cornified envelope 3C (from RefSeq NM_033175.4) ENSMUST00000055375.1 ENSMUST00000055375.2 ENSMUST00000055375.3 ENSMUST00000055375.4 ENSMUST00000055375.5 Eig3 Lce3c NM_033175 Q91V05 Q91V05_MOUSE Sprrl1 uc008qex.1 uc008qex.2 uc008qex.3 uc008qex.4 Belongs to the LCE family. epidermis development uc008qex.1 uc008qex.2 uc008qex.3 uc008qex.4 
ENSMUST00000055389.9 Xxylt1 ENSMUST00000055389.9 xyloside xylosyltransferase 1 (from RefSeq NM_198626.2) E9QL73 ENSMUST00000055389.1 ENSMUST00000055389.2 ENSMUST00000055389.3 ENSMUST00000055389.4 ENSMUST00000055389.5 ENSMUST00000055389.6 ENSMUST00000055389.7 ENSMUST00000055389.8 NM_198626 Q3TLX5 Q3U4G3 Q8K2I0 XXLT1_MOUSE uc007yxa.1 uc007yxa.2 uc007yxa.3 uc007yxa.4 Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose. Known targets include Notch proteins and coagulation factors, such as F9. Reaction=3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)- alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:22820, Rhea:RHEA-COMP:14611, Rhea:RHEA-COMP:14619, ChEBI:CHEBI:15378, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:140575, ChEBI:CHEBI:140599; EC=2.4.2.62; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Has the highest in vitro activity with 20 mM Mn(2+), a concentration entirely out of the physiological range. Can also utilize Mg(2+), suggesting this may be the physiological cofactor. ; Homodimer (PubMed:26414444). Dimer formation may be essential for the retention in endoplasmic reticulum (Probable). Q3U4G3; P00740: F9; Xeno; NbExp=3; IntAct=EBI-16178491, EBI-9640450; Endoplasmic reticulum membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 8 family. It is uncertain whether Met-1 or Met-14 is the initiator. Sequence=AAH31419.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; magnesium ion binding protein binding endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane O-glycan processing transferase activity transferase activity, transferring glycosyl groups manganese ion binding integral component of endoplasmic reticulum membrane UDP-xylosyltransferase activity metal ion binding uc007yxa.1 uc007yxa.2 uc007yxa.3 uc007yxa.4 
ENSMUST00000055390.6 Rhoj ENSMUST00000055390.6 ras homolog family member J (from RefSeq NM_023275.2) Arhj ENSMUST00000055390.1 ENSMUST00000055390.2 ENSMUST00000055390.3 ENSMUST00000055390.4 ENSMUST00000055390.5 NM_023275 Q3TX76 Q920E4 Q9CQA7 Q9ER71 RHOJ_MOUSE Rhoi Rhot Tc10l Tcl uc007nxc.1 uc007nxc.2 uc007nxc.3 Plasma membrane-associated small GTPase specifically involved in angiogenesis (By similarity). Required for endothelial cell migration during vascular development via its interaction with GLUL (By similarity). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:10967094). Interacts with the CRIB domains of proteins such as Pak1 and Was/Wasp (PubMed:10967094). Interacts with GLUL (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Note=Localization to the plasma membrane is regulated by GLUL. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ER71-1; Sequence=Displayed; Name=2; IsoId=Q9ER71-2; Sequence=VSP_005709; Highly expressed in heart with moderate levels in lung and liver (PubMed:10967094). Very low levels detected in brain, spleen, skeletal muscle, kidney and testis (PubMed:10967094). Palmitoylated; regulates localization to the plasma membrane and may be mediated by GLUL. Belongs to the small GTPase superfamily. Rho family. nucleotide binding angiogenesis GTPase activity protein binding GTP binding cellular_component cytoplasm plasma membrane cell cortex endocytosis actin filament organization establishment or maintenance of cell polarity small GTPase mediated signal transduction Rho protein signal transduction regulation of cell shape regulation of endothelial cell migration membrane protein kinase binding cell projection assembly actin cytoskeleton organization regulation of actin cytoskeleton organization cell projection retina vasculature morphogenesis in camera-type eye positive regulation of cell migration involved in sprouting angiogenesis regulation of sprouting angiogenesis uc007nxc.1 uc007nxc.2 uc007nxc.3 
ENSMUST00000055404.8 9930022D16Rik ENSMUST00000055404.8 9930022D16Rik (from geneSymbol) 9930022D16Rik AK036894 ENSMUST00000055404.1 ENSMUST00000055404.2 ENSMUST00000055404.3 ENSMUST00000055404.4 ENSMUST00000055404.5 ENSMUST00000055404.6 ENSMUST00000055404.7 Q8BG27 Q8BG27_MOUSE uc007mcf.1 uc007mcf.2 molecular_function cellular_component biological_process uc007mcf.1 uc007mcf.2 
ENSMUST00000055406.9 Stkld1 ENSMUST00000055406.9 serine/threonine kinase-like domain containing 1, transcript variant 2 (from RefSeq NM_198628.3) A2ALB0 ENSMUST00000055406.1 ENSMUST00000055406.2 ENSMUST00000055406.3 ENSMUST00000055406.4 ENSMUST00000055406.5 ENSMUST00000055406.6 ENSMUST00000055406.7 ENSMUST00000055406.8 Gm711 NM_198628 Q80YS9 STKL1_MOUSE Sgk071 uc008iwm.1 uc008iwm.2 The protein kinase domain is predicted to be catalytically inactive. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily. Asn-126 is present instead of the conserved Asp which is expected to be an active site residue. Sequence=BC050806; Type=Frameshift; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding cellular_component protein phosphorylation uc008iwm.1 uc008iwm.2 
ENSMUST00000055408.13 Bicdl1 ENSMUST00000055408.13 BICD family like cargo adaptor 1, transcript variant 3 (from RefSeq NR_151599.1) A0JNT9 BICL1_MOUSE Bicdr1 Ccdc64 ENSMUST00000055408.1 ENSMUST00000055408.10 ENSMUST00000055408.11 ENSMUST00000055408.12 ENSMUST00000055408.2 ENSMUST00000055408.3 ENSMUST00000055408.4 ENSMUST00000055408.5 ENSMUST00000055408.6 ENSMUST00000055408.7 ENSMUST00000055408.8 ENSMUST00000055408.9 NR_151599 Q8C9J5 Q8CB56 Q8R1D2 uc008zel.1 uc008zel.2 uc008zel.3 Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:29420470, PubMed:33734450, PubMed:36071160). Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis. Part of a tripartite complex with dynein and dynactin, acts an adapter linking the dynein motor complex and dynactin (PubMed:29420470, PubMed:33734450, PubMed:36071160). Interacts with KIF1C. Interacts with RAB6A and RAB6B; interaction is specific to Rab6. A0JNT9; P35279: Rab6a; NbExp=6; IntAct=EBI-7893170, EBI-444674; A0JNT9; P61294: Rab6b; NbExp=2; IntAct=EBI-7893170, EBI-529766; A0JNT9; O43896: KIF1C; Xeno; NbExp=3; IntAct=EBI-7893170, EBI-1644048; Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes around the centrosome. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A0JNT9-1; Sequence=Displayed; Name=2; IsoId=A0JNT9-2; Sequence=VSP_027971, VSP_027973; Name=3; IsoId=A0JNT9-3; Sequence=VSP_027970, VSP_027972, VSP_027974, VSP_027975; Highly expressed during early embryonic development. Predominantly expressed in kidney, undifferentiated neural tissue and developing eye. Predominately expressed in early developing neurons before the stage of neurite outgrowth and elongation. Then, expression strongly declines during neuronal development. Belongs to the BICDR family. protein binding cytoplasm centrosome microtubule organizing center cytoskeleton nervous system development Rab GTPase binding neuron projection development dynactin binding vesicle transport along microtubule Golgi to secretory granule transport uc008zel.1 uc008zel.2 uc008zel.3 
ENSMUST00000055409.6 Nags ENSMUST00000055409.6 N-acetylglutamate synthase (from RefSeq NM_145829.2) B1AQG2 ENSMUST00000055409.1 ENSMUST00000055409.2 ENSMUST00000055409.3 ENSMUST00000055409.4 ENSMUST00000055409.5 NAGS_MOUSE NM_145829 Q8C6G6 Q8CI77 Q8K1R8 Q8R4H7 uc007lqp.1 uc007lqp.2 uc007lqp.3 uc007lqp.4 Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity. Reaction=acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate; Xref=Rhea:RHEA:24292, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:44337, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.1; Evidence=; Increased by L-arginine. Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl- L-ornithine from L-glutamate: step 1/4. Homodimer (By similarity). Homotetramer (PubMed:23894642). Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R4H7-1; Sequence=Displayed; Name=2; IsoId=Q8R4H7-2; Sequence=VSP_015620; Highly expressed in the liver and small intestine. Weakly expressed in the kidney, spleen and testis. The amino-acid kinase (AAK) domain mediates binding of the allosteric activator L-arginine. Probably processed by mitochondrial processing peptidase (MPP). The long form has not yet been isolated. Belongs to the acetyltransferase family. urea cycle acetyl-CoA:L-glutamate N-acetyltransferase activity mitochondrion mitochondrial matrix arginine biosynthetic process glutamate metabolic process phosphorylation transferase activity transferase activity, transferring acyl groups arginine binding acetylglutamate kinase activity uc007lqp.1 uc007lqp.2 uc007lqp.3 uc007lqp.4 
ENSMUST00000055413.13 2510002D24Rik ENSMUST00000055413.13 RIKEN cDNA 2510002D24 gene (from RefSeq NM_001033164.2) CV039_MOUSE ENSMUST00000055413.1 ENSMUST00000055413.10 ENSMUST00000055413.11 ENSMUST00000055413.12 ENSMUST00000055413.2 ENSMUST00000055413.3 ENSMUST00000055413.4 ENSMUST00000055413.5 ENSMUST00000055413.6 ENSMUST00000055413.7 ENSMUST00000055413.8 ENSMUST00000055413.9 NM_001033164 Q3U595 uc007yoo.1 uc007yoo.2 uc007yoo.3 Negatively regulates long-term potentiation and modulates adult synaptic plasticity (PubMed:35771867). Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites (PubMed:35771867). Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses (PubMed:35771867). Interacts with RTN4 isoform A/Nogo-A; the interaction results in enhanced RTN4-mediated inhibition of AMPA receptor clustering (PubMed:35771867). Also interacts with NCAM1, RANBP2 and CCT8 (PubMed:35771867). Synapse Synaptic cleft Note=Detected in both the presynaptic and postsynaptic regions of the synapse and is secreted from neurons into the synaptic cleft (PubMed:35771867). May be released by neuronal dense core vesicles which mediate the release of cleaved neuropeptides (PubMed:35771867). In the postnatal brain, expressed diffusely throughout the hippocampus at a low level at 8 weeks (at protein level) (PubMed:29571919). At 16 weeks, strongly expressed in the stratum lucidum of the hippocampus (at protein level) (PubMed:29571919). In developing and aging brain, expression is strongest in hippocampus, especially in areas CA3 and CA2, throughout the dorsoventral axis (PubMed:29571919). Expression increases in the hippocampus between 8 and 16 weeks of age (at protein level) (PubMed:35771867). In brain, expression decreases steadily throughout embryonic development (PubMed:29571919). In liver, expression decreases between 11.5 dpc and 13.5 dpc and then remains relatively low (PubMed:29571919). Expression in the heart shows a 50% increase between 11.5 dpc and 13.5 dpc and then decreases (PubMed:29571919). In the postnatal brain, cerebellum levels decline (PubMed:29571919). In cortical tissue, expression significantly decreases by ~40% between P0 and 3 weeks and then returns to levels comparable to P0 in adult stages (PubMed:29571919). In the hippocampus, expression significantly drops by 40% between P0 and 3 weeks with a slight increase observed between 8 and 16 weeks of age (PubMed:29571919). Rapidly degraded by proteolysis following neuronal stimulation, resulting in increased AMPA receptor clustering. Belongs to the UPF0545 family. molecular_function cellular_component biological_process uc007yoo.1 uc007yoo.2 uc007yoo.3 
ENSMUST00000055421.6 Tmem239 ENSMUST00000055421.6 transmembrane 239 (from RefSeq NM_025753.3) ENSMUST00000055421.1 ENSMUST00000055421.2 ENSMUST00000055421.3 ENSMUST00000055421.4 ENSMUST00000055421.5 NM_025753 Q9DA47 TM239_MOUSE uc008mit.1 uc008mit.2 uc008mit.3 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc008mit.1 uc008mit.2 uc008mit.3 
ENSMUST00000055424.13 Cenpx ENSMUST00000055424.13 centromere protein X, transcript variant 1 (from RefSeq NM_016665.3) A2AC08 CENPX_MOUSE ENSMUST00000055424.1 ENSMUST00000055424.10 ENSMUST00000055424.11 ENSMUST00000055424.12 ENSMUST00000055424.2 ENSMUST00000055424.3 ENSMUST00000055424.4 ENSMUST00000055424.5 ENSMUST00000055424.6 ENSMUST00000055424.7 ENSMUST00000055424.8 ENSMUST00000055424.9 Faap10 Mhf2 NM_016665 O08693 O08694 O08695 Q8BPD7 Q8C4X1 Stra13 uc007muc.1 uc007muc.2 uc007muc.3 DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own. Heterodimer with CENPX, sometimes called MHF; this interaction stabilizes both partners. MHF heterodimers can assemble to form tetrameric structures. MHF also coassemble with CENPT-CENPW heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex. Forms a discrete complex with FANCM and CENPX, called FANCM- MHF; this interaction, probably mediated by direct binding between CENPS and FANCM, leads to synergistic activation of double-stranded DNA binding and strongly stimulates FANCM-mediated DNA remodeling. Recruited by FANCM to the Fanconi anemia (FA) core complex, which consists of CENPS, CENPX, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FAAP24 and FAAP100. The FA core complex associates with Bloom syndrome (BLM) complex, which consists of at least BLM, DNA topoisomerase 3-alpha (TOP3A), RMI1/BLAP75, RPA1/RPA70 and RPA2/RPA32. The super complex between FA and BLM is called BRAFT. Nucleus Chromosome, centromere Chromosome, centromere, kinetochore Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPX being less stably bound at the kinetochore than CENPS. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Variant 2; IsoId=Q8C4X1-1; Sequence=Displayed; Name=2; Synonyms=Variant 3; IsoId=Q8C4X1-2; Sequence=VSP_033950; Name=3; Synonyms=Variant 1; IsoId=Q8C4X1-3; Sequence=VSP_033951; Name=4; IsoId=Q8C4X1-4; Sequence=VSP_033952; By retinoic acid. Belongs to the CENP-X/MHF2 family. resolution of meiotic recombination intermediates chromosome, centromeric region kinetochore condensed chromosome kinetochore DNA binding double-stranded DNA binding nucleus chromosome DNA repair cellular response to DNA damage stimulus cell cycle replication fork processing Fanconi anaemia nuclear complex cell division kinetochore assembly FANCM-MHF complex uc007muc.1 uc007muc.2 uc007muc.3 
ENSMUST00000055433.5 Spsb4 ENSMUST00000055433.5 splA/ryanodine receptor domain and SOCS box containing 4 (from RefSeq NM_145134.3) ENSMUST00000055433.1 ENSMUST00000055433.2 ENSMUST00000055433.3 ENSMUST00000055433.4 NM_145134 Q8BJI9 Q8R5B6 Q8VHS8 SPSB4_MOUSE Ssb4 uc009rcx.1 uc009rcx.2 uc009rcx.3 Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of the EphB2/CTF2 (By similarity). Regulates cellular clock function by mediating ubiquitination and proteasomal degradation of the circadian transcriptional repressor NR1D1 (By similarity). Protein modification; protein ubiquitination. Component of the probable ECS(SPSB4) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB4 (By similarity). Interacts with CUL5; RNF7; ELOB and ELOC (By similarity). Interacts with MET (PubMed:16369487). Interacts (via B30.2/SPRY domain) with PAWR; this interaction occurs in association with the Elongin BC complex (PubMed:16369487, PubMed:20561531). Interacts with NOS2 (PubMed:20603330). Interacts with EPHB2 (By similarity). Q8R5B6; Q96IZ0: PAWR; Xeno; NbExp=3; IntAct=EBI-8821982, EBI-595869; Cytoplasm Cytoplasm, cytosol Note=Exhibits a diffuse cytosolic localization. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R5B6-1; Sequence=Displayed; Name=2; IsoId=Q8R5B6-2; Sequence=VSP_018614; The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). Essential for its ability to link NOS2 and the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). Belongs to the SPSB family. protein binding cytoplasm cytosol ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex intracellular signal transduction regulation of circadian rhythm proteasome-mediated ubiquitin-dependent protein catabolic process rhythmic process positive regulation of protein polyubiquitination protein binding, bridging involved in substrate recognition for ubiquitination uc009rcx.1 uc009rcx.2 uc009rcx.3 
ENSMUST00000055436.5 Hpdl ENSMUST00000055436.5 4-hydroxyphenylpyruvate dioxygenase-like (from RefSeq NM_146256.3) ENSMUST00000055436.1 ENSMUST00000055436.2 ENSMUST00000055436.3 ENSMUST00000055436.4 Gloxd1 HPDL_MOUSE NM_146256 Q8K248 uc008uho.1 uc008uho.2 uc008uho.3 May have dioxygenase activity. Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Note=Binds 1 Fe cation per subunit. ; Mitochondrion Belongs to the 4HPPD family. molecular_function 4-hydroxyphenylpyruvate dioxygenase activity cellular_component biological_process aromatic amino acid family metabolic process oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen metal ion binding dioxygenase activity oxidation-reduction process uc008uho.1 uc008uho.2 uc008uho.3 
ENSMUST00000055438.5 Ppm1e ENSMUST00000055438.5 protein phosphatase 1E (PP2C domain containing) (from RefSeq NM_177167.4) Camkn ENSMUST00000055438.1 ENSMUST00000055438.2 ENSMUST00000055438.3 ENSMUST00000055438.4 Kiaa1072 NM_177167 PPM1E_MOUSE Q5SX30 Q80TL0 Q8BGM6 Q8CB81 uc007kto.1 uc007kto.2 uc007kto.3 Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2. Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 (By similarity). Dephosphorylates PRKAA2. Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit. ; Heterotrimer. Interacts with PAX1 and ARHGEF6 (or ARHGEF7) (By similarity). Nucleus Cytoplasm Note=A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full-length, minor form, is found in the nucleus. Belongs to the PP2C family. catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity nucleus nucleolus cytoplasm mitochondrion cytosol negative regulation of protein kinase activity protein dephosphorylation hydrolase activity macromolecular complex cellular response to drug peptidyl-threonine dephosphorylation cation binding metal ion binding positive regulation of stress fiber assembly uc007kto.1 uc007kto.2 uc007kto.3 
ENSMUST00000055444.6 Scgb2b24 ENSMUST00000055444.6 secretoglobin, family 2B, member 24 (from RefSeq NM_177446.2) Abpz ENSMUST00000055444.1 ENSMUST00000055444.2 ENSMUST00000055444.3 ENSMUST00000055444.4 ENSMUST00000055444.5 NM_177446 Q7M747 S2B24_MOUSE uc009gim.1 uc009gim.2 uc009gim.3 Secreted Expressed in lacrimal gland, at higher level in males than females. Belongs to the secretoglobin family. molecular_function cellular_component extracellular region extracellular space biological_process uc009gim.1 uc009gim.2 uc009gim.3 
ENSMUST00000055454.14 Prr3 ENSMUST00000055454.14 proline-rich polypeptide 3, transcript variant 1 (from RefSeq NM_145487.4) Cat56 ENSMUST00000055454.1 ENSMUST00000055454.10 ENSMUST00000055454.11 ENSMUST00000055454.12 ENSMUST00000055454.13 ENSMUST00000055454.2 ENSMUST00000055454.3 ENSMUST00000055454.4 ENSMUST00000055454.5 ENSMUST00000055454.6 ENSMUST00000055454.7 ENSMUST00000055454.8 ENSMUST00000055454.9 NM_145487 PRR3_MOUSE Q811B5 Q91YI5 uc008cjm.1 uc008cjm.2 uc008cjm.3 uc008cjm.4 cellular_component biological_process metal ion binding uc008cjm.1 uc008cjm.2 uc008cjm.3 uc008cjm.4 
ENSMUST00000055458.6 Cdc42ep2 ENSMUST00000055458.6 CDC42 effector protein 2 (from RefSeq NM_026772.2) BORG1_MOUSE Borg1 Cep2 ENSMUST00000055458.1 ENSMUST00000055458.2 ENSMUST00000055458.3 ENSMUST00000055458.4 ENSMUST00000055458.5 NM_026772 Q8JZX9 uc008gfz.1 uc008gfz.2 uc008gfz.3 uc008gfz.4 Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). Interacts with CDC42 and RHOQ in a GTP-dependent manner, and with SEPT7. Endomembrane system ; Peripheral membrane protein Cytoplasm, cytoskeleton The CRIB domain mediates interaction with CDC42. Belongs to the BORG/CEP family. opioid peptide activity GTPase activator activity cytoplasm cytosol cytoskeleton plasma membrane Rho protein signal transduction regulation of cell shape endomembrane system microtubule cytoskeleton membrane GTP-Rho binding actin cytoskeleton organization positive regulation of actin filament polymerization positive regulation of pseudopodium assembly positive regulation of GTPase activity phagocytic vesicle cellular response to interferon-gamma uc008gfz.1 uc008gfz.2 uc008gfz.3 uc008gfz.4 
ENSMUST00000055475.9 Gpr18 ENSMUST00000055475.9 G protein-coupled receptor 18 (from RefSeq NM_182806.2) ENSMUST00000055475.1 ENSMUST00000055475.2 ENSMUST00000055475.3 ENSMUST00000055475.4 ENSMUST00000055475.5 ENSMUST00000055475.6 ENSMUST00000055475.7 ENSMUST00000055475.8 GPR18_MOUSE Gpr18 NM_182806 Q3T9N3 Q8K1Z6 uc007vap.1 uc007vap.2 uc007vap.3 Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (By similarity). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:23104136). Can also be activated by plant-derived and synthetic cannabinoid agonists (By similarity). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (By similarity). May contribute to regulation of the immune system (By similarity). Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (PubMed:25348153, PubMed:26197390). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (PubMed:23461720, PubMed:27893106). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (By similarity). Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane Expressed in the eye including cornea, retina, iris and ciliary epithelium (at protein level) (PubMed:23461720). Expressed in spleen, liver and lymphocytes with highest expression levels in intestinal intraepithelial lymphocytes (PubMed:25348153, PubMed:26197390). No visible phenotype (PubMed:26197390). However, reduced number of CD8alphaalpha gammadeltaT IELs has been reported (PubMed:25348153). Belongs to the G-protein coupled receptor 1 family. CD8-positive, alpha-beta intraepithelial T cell differentiation CD8-positive, gamma-delta intraepithelial T cell differentiation negative regulation of leukocyte chemotaxis G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane cytoplasmic vesicle membrane cytoplasmic vesicle negative regulation of tumor necrosis factor production positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway uc007vap.1 uc007vap.2 uc007vap.3 
ENSMUST00000055485.12 Lsm14b ENSMUST00000055485.12 LSM family member 14B, transcript variant 2 (from RefSeq NM_177727.5) A2AC71 ENSMUST00000055485.1 ENSMUST00000055485.10 ENSMUST00000055485.11 ENSMUST00000055485.2 ENSMUST00000055485.3 ENSMUST00000055485.4 ENSMUST00000055485.5 ENSMUST00000055485.6 ENSMUST00000055485.7 ENSMUST00000055485.8 ENSMUST00000055485.9 Fam61b LS14B_MOUSE Lsm14b NM_177727 Q8CGC4 Rap55b uc008ohy.1 uc008ohy.2 Required for oocyte meiotic maturation (PubMed:28458300). May be involved in the storage of translationally inactive mRNAs and protect them from degradation (PubMed:28458300). Plays a role in control of mRNA translation (By similarity). Component of a ribonucleoprotein (RNP) complex. Interacts with DDX6. Belongs to the LSM14 family. Sequence=AAH40823.1; Type=Erroneous initiation; Evidence=; regulation of translation multicellular organism development biological_process uc008ohy.1 uc008ohy.2 
ENSMUST00000055490.9 Otop2 ENSMUST00000055490.9 otopetrin 2, transcript variant 1 (from RefSeq NM_172801.2) ENSMUST00000055490.1 ENSMUST00000055490.2 ENSMUST00000055490.3 ENSMUST00000055490.4 ENSMUST00000055490.5 ENSMUST00000055490.6 ENSMUST00000055490.7 ENSMUST00000055490.8 NM_172801 OTOP2_MOUSE Otop2 Q80SX5 Q8CE77 uc007mhb.1 uc007mhb.2 Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. Cell membrane ; Multi-pass membrane protein Expressed at higher level in stomach, testis and olfactory bulb. Belongs to the otopetrin family. cellular_component plasma membrane ion transport hydrogen ion channel activity membrane integral component of membrane hydrogen ion transmembrane transport uc007mhb.1 uc007mhb.2 
ENSMUST00000055495.6 Pcdhb12 ENSMUST00000055495.6 protocadherin beta 12 (from RefSeq NM_053137.2) ENSMUST00000055495.1 ENSMUST00000055495.2 ENSMUST00000055495.3 ENSMUST00000055495.4 ENSMUST00000055495.5 F6V243 NM_053137 Pcdhb12 Q91Y07 Q91Y07_MOUSE uc008epx.1 uc008epx.2 molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epx.1 uc008epx.2 
ENSMUST00000055497.15 Taf9b ENSMUST00000055497.15 TATA-box binding protein associated factor 9B, transcript variant 2 (from RefSeq NM_001001176.2) A2AP80 ENSMUST00000055497.1 ENSMUST00000055497.10 ENSMUST00000055497.11 ENSMUST00000055497.12 ENSMUST00000055497.13 ENSMUST00000055497.14 ENSMUST00000055497.2 ENSMUST00000055497.3 ENSMUST00000055497.4 ENSMUST00000055497.5 ENSMUST00000055497.6 ENSMUST00000055497.7 ENSMUST00000055497.8 ENSMUST00000055497.9 NM_001001176 Q3UXZ3 Q3V2M4 Q6NZA9 Q80WW6 TAF9B_MOUSE Taf9l uc009ubq.1 uc009ubq.2 uc009ubq.3 uc009ubq.4 Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity). Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N- terminal domain of p53/TP53 which is essential for transcription (By similarity). Nucleus Belongs to the TAF9 family. Sequence=AAH51635.1; Type=Erroneous initiation; Evidence=; Sequence=BAE20773.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter SAGA complex nucleus transcription factor TFIID complex DNA-templated transcription, initiation transcription from RNA polymerase II promoter transcription factor binding positive regulation of cell growth transcription factor TFTC complex negative regulation of apoptotic process histone H3 acetylation transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein stabilization histone acetyltransferase activity uc009ubq.1 uc009ubq.2 uc009ubq.3 uc009ubq.4 
ENSMUST00000055502.5 Krtap3-1 ENSMUST00000055502.5 keratin associated protein 3-1 (from RefSeq NM_023511.1) A2A591 ENSMUST00000055502.1 ENSMUST00000055502.2 ENSMUST00000055502.3 ENSMUST00000055502.4 KRA31_MOUSE Krtap3-1 NM_023511 O08634 uc007ljb.1 uc007ljb.2 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). Interacts with hair keratins. Belongs to the KRTAP type 3 family. molecular_function structural molecule activity cellular_component intermediate filament biological_process keratin filament uc007ljb.1 uc007ljb.2 
ENSMUST00000055506.9 Gtf3c1 ENSMUST00000055506.9 general transcription factor III C 1 (from RefSeq NM_207239.1) ENSMUST00000055506.1 ENSMUST00000055506.2 ENSMUST00000055506.3 ENSMUST00000055506.4 ENSMUST00000055506.5 ENSMUST00000055506.6 ENSMUST00000055506.7 ENSMUST00000055506.8 NM_207239 Q8CAL9 Q8K284 TF3C1_MOUSE uc009jqh.1 uc009jqh.2 uc009jqh.3 Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element (By similarity). Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with IGHMBP2. Interacts with MAF1. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K284-1; Sequence=Displayed; Name=2; IsoId=Q8K284-2; Sequence=VSP_010576; Name=3; IsoId=Q8K284-3; Sequence=VSP_010573, VSP_010574, VSP_010575; [Isoform 2]: Incomplete sequence. Belongs to the TFIIIC subunit 1 family. Sequence=AAH32208.1; Type=Erroneous initiation; Evidence=; transcription factor TFIIIC complex RNA polymerase III type 1 promoter sequence-specific DNA binding RNA polymerase III type 2 promoter sequence-specific DNA binding DNA binding nucleus nucleolus transcription initiation from RNA polymerase III promoter 5S class rRNA transcription from RNA polymerase III type 1 promoter ribonucleoprotein complex transcription factor activity, core RNA polymerase III binding uc009jqh.1 uc009jqh.2 uc009jqh.3 
ENSMUST00000055518.13 Pik3r1 ENSMUST00000055518.13 phosphoinositide-3-kinase regulatory subunit 1, transcript variant 2 (from RefSeq NM_001077495.2) ENSMUST00000055518.1 ENSMUST00000055518.10 ENSMUST00000055518.11 ENSMUST00000055518.12 ENSMUST00000055518.2 ENSMUST00000055518.3 ENSMUST00000055518.4 ENSMUST00000055518.5 ENSMUST00000055518.6 ENSMUST00000055518.7 ENSMUST00000055518.8 ENSMUST00000055518.9 NM_001077495 P26450 P85A_MOUSE Q8K3B3 uc007rrt.1 uc007rrt.2 uc007rrt.3 uc007rrt.4 uc007rrt.5 Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues (PubMed:27708159). Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926). Heterodimer of a regulatory subunit PIK3R1 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts (via SH2 domains) with CCDC88A/GIV (tyrosine-phosphorylated form); the interaction enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (By similarity). Interacts with XBP1 isoform 2; the interaction is direct and induces translocation of XBP1 isoform 2 into the nucleus in a ER stress- and/or insulin-dependent but PI3K-independent manner (PubMed:20348926). Interacts with PIK3R2; the interaction is dissociated in an insulin- dependent manner (PubMed:20348926). Interacts with phosphorylated LAT, LAX1 and TRAT1 upon TCR activation. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine-phosphorylated IGF1R in vitro. Interacts with IRS1 and phosphorylated IRS4. Interacts with NISCH and RUFY3 (By similarity). Interacts with phosphorylated TOM1L1. Interacts with phosphorylated LIME1 upon TCR or BCR activation. Interacts with CBLB. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with SOCS7 and HCST. Interacts with AXL, FASLG, FGR, HCK, KIT and BCR. Interacts with PTK2/FAK1 (By similarity). Interacts with PDGFRB (tyrosine phosphorylated) (By similarity). Interacts with NTRK1 (phosphorylated upon ligand-binding) (By similarity). Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (PubMed:9312046). Interacts with FER. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated) (Probable). Interacts with PDGFRA (tyrosine phosphorylated). Interacts with LYN (via SH3 domain); this enhances enzyme activity. Interacts with ERBB4. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with FAM83B; activates the PI3K/AKT signaling cascade (By similarity). Interacts with APPL1 and APPL2 (PubMed:25328665). Interacts with SRC (By similarity). Interacts with ALOX5; this interaction bridges ALOX5 with CD40 after CD40 ligation in B cells and leads to the production of reactive oxygen species (ROS) (By similarity). Interacts with TYK2 (By similarity). Interacts with nephrin NPHN1; the interaction is reduced by high glucose levels (By similarity). P26450; O88665: Brd7; NbExp=11; IntAct=EBI-641764, EBI-643930; P26450; Q62448: Eif4g2; NbExp=3; IntAct=EBI-641764, EBI-296494; P26450; Q9WVS0: Icos; NbExp=2; IntAct=EBI-641764, EBI-16721736; P26450; P35569: Irs1; NbExp=3; IntAct=EBI-641764, EBI-400825; P26450; P42337: Pik3ca; NbExp=7; IntAct=EBI-641764, EBI-641748; P26450; Q8BTI9: Pik3cb; NbExp=5; IntAct=EBI-641764, EBI-644672; P26450; O35904-2: Pik3cd; NbExp=2; IntAct=EBI-641764, EBI-6470774; P26450; Q8R5H6: Wasf1; NbExp=2; IntAct=EBI-641764, EBI-774719; P26450; Q8IZP0: ABI1; Xeno; NbExp=3; IntAct=EBI-641764, EBI-375446; The SH3 domain mediates the binding to CBLB. Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation. Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear. Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR (By similarity). Phosphorylated by CSF1R. Phosphorylated by ERBB4. Phosphorylated on tyrosine residues by TEK/TIE2. In adipose tissue, polyubiquitinated by the BCR(KBTBD2) E3 ubiquitin ligase complex; recognized by KBTBD2 through the SH2 domains, undergoes 'Lys-48'-linked polyubiquitination leading to its degradation. Double knockouts for KBTBD2 and PIK3R1 have increased body weight, normal fat storage, blood glucose and insulin levels. Belongs to the PI3K p85 subunit family. cellular glucose homeostasis phosphotyrosine binding positive regulation of protein phosphorylation negative regulation of cell-matrix adhesion receptor binding insulin receptor binding insulin-like growth factor receptor binding platelet-derived growth factor receptor binding neurotrophin TRKA receptor binding protein binding calmodulin binding nucleus cytoplasm cis-Golgi network cytosol plasma membrane cell-cell junction phosphatidylinositol 3-kinase complex phosphatidylinositol 3-kinase complex, class IA glucose metabolic process protein phosphorylation protein import into nucleus negative regulation of cell adhesion signal transduction protein C-terminus binding transcription factor binding insulin receptor signaling pathway extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of heart rate positive regulation of gene expression negative regulation of muscle cell apoptotic process phosphatidylinositol 3-kinase signaling protein transport membrane 1-phosphatidylinositol-3-kinase activity protein kinase binding protein phosphatase binding protein domain specific binding negative regulation of cell-cell adhesion B cell differentiation estrogen receptor binding positive regulation of cell migration receptor tyrosine kinase binding ubiquitin protein ligase binding positive regulation of tumor necrosis factor production response to insulin cellular response to insulin stimulus macromolecular complex positive regulation of RNA splicing cellular response to UV response to endoplasmic reticulum stress phosphatidylinositol 3-kinase regulator activity phosphatidylinositol-3-phosphate biosynthetic process phosphatidylinositol 3-kinase regulatory subunit binding positive regulation of protein import into nucleus neuron projection negative regulation of apoptotic process ErbB-3 class receptor binding regulation of phosphatidylinositol 3-kinase activity insulin binding insulin receptor substrate binding positive regulation of myoblast differentiation negative regulation of osteoclast differentiation negative regulation of blood pressure negative regulation of proteolysis positive regulation of transcription from RNA polymerase II promoter regulation of insulin receptor signaling pathway phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity protein heterodimerization activity insulin-like growth factor receptor signaling pathway negative regulation of smooth muscle cell proliferation protein stabilization ATPase binding phosphoprotein binding response to glucocorticoid regulation of stress fiber assembly response to cAMP growth hormone receptor signaling pathway positive regulation of endoplasmic reticulum unfolded protein response regulation of protein localization to plasma membrane perinuclear endoplasmic reticulum membrane uc007rrt.1 uc007rrt.2 uc007rrt.3 uc007rrt.4 uc007rrt.5 
ENSMUST00000055528.11 Zscan22 ENSMUST00000055528.11 zinc finger and SCAN domain containing 22, transcript variant 3 (from RefSeq NM_001290438.1) ENSMUST00000055528.1 ENSMUST00000055528.10 ENSMUST00000055528.2 ENSMUST00000055528.3 ENSMUST00000055528.4 ENSMUST00000055528.5 ENSMUST00000055528.6 ENSMUST00000055528.7 ENSMUST00000055528.8 ENSMUST00000055528.9 Hkr2 NM_001290438 Q8BGS5 Q8BGS5_MOUSE Zscan22 uc009fel.1 uc009fel.2 uc009fel.3 uc009fel.4 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009fel.1 uc009fel.2 uc009fel.3 uc009fel.4 
ENSMUST00000055535.9 Prtg ENSMUST00000055535.9 protogenin (from RefSeq NM_175485.4) A4FUS8 A4FUS9 ENSMUST00000055535.1 ENSMUST00000055535.2 ENSMUST00000055535.3 ENSMUST00000055535.4 ENSMUST00000055535.5 ENSMUST00000055535.6 ENSMUST00000055535.7 ENSMUST00000055535.8 NM_175485 PRTG_MOUSE Prtg Q2EY15 Q2VWP8 Q8BJK6 Q8BYL5 uc009qqh.1 uc009qqh.2 uc009qqh.3 May play a role in anteroposterior axis elongation. Membrane ; Single-pass membrane protein From mid-gastrulation to early somite stages, restricted to posterior neural plate and mesoderm with an anterior limit at the level of the rhombencephalon. Posterior restriction is progressively lost during somitogenesis. Expression is maintained in the neural tube and paraxial mesoderm during this process. As development proceeds, further restricted to the dorsal parts of the spinal cord and somites. In parallel, expression progresses caudally during axis elongation. Belongs to the immunoglobulin superfamily. DCC family. Sequence=BAC38947.1; Type=Erroneous initiation; Evidence=; plasma membrane homophilic cell adhesion via plasma membrane adhesion molecules multicellular organism development axon guidance membrane integral component of membrane axon signaling receptor activity identical protein binding negative regulation of neurogenesis dendrite self-avoidance protein binding involved in cell-cell adhesion uc009qqh.1 uc009qqh.2 uc009qqh.3 
ENSMUST00000055539.11 Timeless ENSMUST00000055539.11 timeless circadian clock 1, transcript variant 4 (from RefSeq NM_001164081.1) ENSMUST00000055539.1 ENSMUST00000055539.10 ENSMUST00000055539.2 ENSMUST00000055539.3 ENSMUST00000055539.4 ENSMUST00000055539.5 ENSMUST00000055539.6 ENSMUST00000055539.7 ENSMUST00000055539.8 ENSMUST00000055539.9 NM_001164081 Q63ZX9 Q6P204 Q6PDL4 Q7TPV8 Q8R0Q2 Q9R1X4 Q9R268 Q9Z0E7 TIM_MOUSE Tim1 Timeless Timeless1 uc007hlv.1 uc007hlv.2 uc007hlv.3 uc007hlv.4 The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:9856465, PubMed:23418588, PubMed:10428031, PubMed:12875843, PubMed:31138685). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:12875843). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (By similarity). TIMELESS promotes TIPIN nuclear localization (PubMed:12875843, PubMed:31138685). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (By similarity). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:12875843). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (By similarity). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:23418588). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:10428031, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:9856465). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (PubMed:10963667). Monomer (By similarity). Homodimer or homomultimer (PubMed:12875843, PubMed:23418588). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSKN1D and/or CSNK1E, TIMELESS, and the PER proteins (PubMed:9856465). Interacts directly with PER2; the interaction with PER2 is via its second PAS domain (PubMed:14564007). Interacts directly with PER1 and PER3 (PubMed:9856465, PubMed:10231394, PubMed:14564007). Interacts with CRY1 (PubMed:10428031, PubMed:23418588, PubMed:24489120). Interacts with CRY2 (PubMed:10428031). Interacts with CHEK1, ATR and ATRIP (By similarity). Interacts with CLSPN (By similarity). Interacts (via N-terminus) with TIPIN (PubMed:12875843). The TIMELESS-TIPIN heterodimer binds preferably to guanine-rich quadruplex-forming (G4) DNA structures (By similarity). Associates with the MCM2-7 complex. Interacts with DNA polymerases alpha, delta and epsilon (By similarity). Interacts with DDX11; this interaction increases recruitment of both proteins onto chromatin in response to replication stress induction by hydroxyurea (By similarity). Interacts with PARP1; interaction is direct and independent of poly-ADP-ribose (By similarity). Q9R1X4; O35973: Per1; NbExp=3; IntAct=EBI-1793117, EBI-1266764; Nucleus romosome Note=In response to double-strand breaks (DSBs), accumulates at DNA damage sites via its interaction with PARP1. Event=Alternative splicing; Named isoforms=6; Name=1 IsoId=Q9R1X4-1; Sequence=Displayed; Name=2 ; IsoId=Q9R1X4-2; Sequence=VSP_051695; Name=3 ; IsoId=Q9R1X4-3; Sequence=VSP_051695, VSP_051696; Name=4 ; Synonyms=TIM-s; IsoId=Q9R1X4-4; Sequence=VSP_051694, VSP_051695; Name=5 ; IsoId=Q9R1X4-5; Sequence=VSP_051694; Name=6 ; IsoId=Q9R1X4-6; Sequence=VSP_051697; Predominantly and robustly expressed in proliferative organs (spleen, thymus, intestine and testis) compared to those more differentiated such as kidney and liver (at protein level). Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Strongly expressed in the suprachiasmatic nucleus (SCN) and pars tuberalis, moderately in the cingulate cortex, pyrimidal cell layer of the piriform cortex, periventricular part of the caudate putamen, and granular layer of the cerebellum, and weakly in the cerebral cortex, gyrus dentatus, hippocampus and thalamic nuclei. In embryonic kidney, expression is highest in regions of active ureteric bud cell branching. Expression is highest in whole embryos at 11 dpc and gradually decreases as embryonic development progresses. At 7.5 dpc, expressed in germ cell layers. At 14.5 dpc, expressed at highest levels in thymus, liver, gastrointestinal tract, lung and the rapidly proliferating ventricular zone of the brain. In retina, expression exhibits a circadian rhythm in the presence of light/dark cycles. In the suprachiasmatic nucleus (SCN), isoform 1 exhibited 24 hours oscillation, isoform 4 is constitutively expressed. Shows a circadian expression pattern in the intestine with peaks at ZT4 and ZT8. Residues 1172-1189 comprise a putative nuclear localization signal; nuclear localization is required for the regulation of period length of the circadian clock. The DNA-binding domain (residues 810-949) binds to both single- stranded DNA (ssDNA) and double-stranded DNA (dsDNA), and has high affinity for DNA sequences rich in guanine that form G-quadruplex (G4) structures. The C-terminal domain, comprising the DNA-binding domain and the PARP1-binding region, is required for the replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures. Belongs to the timeless family. Sequence=AAH52884.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH64788.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; DNA replication checkpoint negative regulation of transcription from RNA polymerase II promoter nuclear chromatin branching involved in ureteric bud morphogenesis kidney development morphogenesis of an epithelium DNA binding protein binding nucleus chromosome DNA repair cellular response to DNA damage stimulus cell cycle multicellular organism development circadian rhythm lung development replication fork protection complex site of double-strand break regulation of circadian rhythm positive regulation of circadian rhythm protein homodimerization activity replication fork arrest cell cycle phase transition negative regulation of transcription, DNA-templated protein heterodimerization activity replication fork protection rhythmic process branching morphogenesis of an epithelial tube cell division cellular response to hydroxyurea cellular response to cisplatin cellular response to bleomycin positive regulation of double-strand break repair via homologous recombination positive regulation of double-strand break repair uc007hlv.1 uc007hlv.2 uc007hlv.3 uc007hlv.4 
ENSMUST00000055545.5 Or13e8 ENSMUST00000055545.5 olfactory receptor family 13 subfamily E member 8 (from RefSeq NM_019485.2) ENSMUST00000055545.1 ENSMUST00000055545.2 ENSMUST00000055545.3 ENSMUST00000055545.4 NM_019485 Olfr70 Or13e8 Q80ZX9 Q80ZX9_MOUSE uc012dde.1 uc012dde.2 uc012dde.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: BC046311.1, BQ714412.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc012dde.1 uc012dde.2 uc012dde.3 
ENSMUST00000055549.4 B3gnt2 ENSMUST00000055549.4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2, transcript variant 2 (from RefSeq NM_001169114.1) B3GN2_MOUSE B3GNT2 B3gnt1 Beta3gnt ENSMUST00000055549.1 ENSMUST00000055549.2 ENSMUST00000055549.3 NM_001169114 Q91V18 Q9Z222 uc007iei.1 uc007iei.2 uc007iei.3 uc007iei.4 Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains (PubMed:9892646). Probably constitutes the main polylactosamine synthase (PubMed:17890318). Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D- glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D- glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:14389, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:133507, ChEBI:CHEBI:134090; EC=2.4.1.149; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Interacts with B3GNT8; this interaction greatly increases B3GNT2 catalytic activity, independently of B3GNT8 enzymatic activity. Golgi apparatus membrane ; Single- pass type II membrane protein Expressed in heart, brain, lung, kidney and testis and, to a lesser extent, in liver and skeletal muscle. No expression in spleen. Strongly reduced number polylactosamine structures on N-glycans in immunological tissues. B-cells and T-cells proliferate show hyperproliferation (PubMed:17890318). Mice also display defective accessory olfactory bulb innervation (PubMed:23006775). Impaired sexual behaviour. While female mice are fertile, males show a reduced rate of reproduction. Defects cannot be attributed to any physical defect in their reproductive organs, suggesting that the phenotype observed may result from an impaired sexual response to female mating partners. Belongs to the glycosyltransferase 31 family. There is some conflicting nomenclature, as some groups still name this protein B3gnt1 (PubMed:18008318). The correct and official nomenclature is however B3gnt2. Name=Functional Glycomics Gateway - GTase; Note=MGC32391: hypothetical protein MGC32391/hypothetical protein MGC32391; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_472"; Name=Functional Glycomics Gateway - GTase; Note=beta 3 GlcNAc-T I; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_571"; Golgi membrane endoplasmic reticulum Golgi apparatus protein glycosylation protein O-linked glycosylation axon guidance sensory perception of smell acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups poly-N-acetyllactosamine biosynthetic process cellular response to leukemia inhibitory factor uc007iei.1 uc007iei.2 uc007iei.3 uc007iei.4 
ENSMUST00000055557.6 Stx19 ENSMUST00000055557.6 syntaxin 19 (from RefSeq NM_026588.1) ENSMUST00000055557.1 ENSMUST00000055557.2 ENSMUST00000055557.3 ENSMUST00000055557.4 ENSMUST00000055557.5 NM_026588 Q8R1Q0 Q9CTR6 Q9CV39 STX19_MOUSE Stx19 Syn9 uc007zpv.1 uc007zpv.2 uc007zpv.3 Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR). Interacts with EGFR. Cell membrane ; Peripheral membrane protein Cytoplasm Expressed in stomach, lung and skin (at protein level). In stomach, strongly expressed in the mucosa of the fundus, in epithelial cells of gastric pits, and in gastric glands (at protein level). In skin, expressed in the epidermis, dermis, and epithelial layer of the hair bulb (at protein level). Detected in stomach and skin from embryonic stage 16 (16 dpc) onwards. Belongs to the syntaxin family. Sequence=BAB26492.1; Type=Frameshift; Evidence=; SNARE binding SNAP receptor activity cytoplasm plasma membrane intracellular protein transport exocytosis vesicle fusion synaptic vesicle endomembrane system membrane integral component of membrane vesicle-mediated transport SNARE complex synaptic vesicle fusion to presynaptic active zone membrane presynaptic membrane vesicle docking presynaptic active zone membrane uc007zpv.1 uc007zpv.2 uc007zpv.3 
ENSMUST00000055558.6 Gimap5 ENSMUST00000055558.6 GTPase, IMAP family member 5 (from RefSeq NM_175035.5) ENSMUST00000055558.1 ENSMUST00000055558.2 ENSMUST00000055558.3 ENSMUST00000055558.4 ENSMUST00000055558.5 GIMA5_MOUSE Ian4l1 Ian5 Imap3 NM_175035 Q501L7 Q549X3 Q8BWF2 uc009bvs.1 uc009bvs.2 uc009bvs.3 This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB126961.1, AK052694.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (PubMed:16509771). Inhibitor of GSK3A. May act by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of bone marrow hematopoietic stem cells, as well as of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (PubMed:18796632, PubMed:21502331). May promote the survival of mature T lymphocytes upon cytokine withdrawal (PubMed:16509771). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (PubMed:25808953). Is a regulator of liver endothelial cell homeostasis (PubMed:33956074). Interacts with BAD, BAK1, BAX, BCL2, BCL2L1/Bcl-xL and BCL2L11/BimEL (PubMed:16509771, PubMed:21502331). The interaction with BAX is increased, when cells initiate apoptosis upon IL2 withdrawal (PubMed:16509771). Forms a complex with BCL2L1 or MCL1 and HSPA8/HSC70; the interaction between HSPA8 and BCL2L1 or MCL1 is impaired in the absence of GIMAP5 (PubMed:21502331). May interact (via N-terminus) with microtubules (By similarity). Q8BWF2; P10417: Bcl2; NbExp=3; IntAct=EBI-15572348, EBI-526314; Q8BWF2; Q07812: BAX; Xeno; NbExp=2; IntAct=EBI-15572348, EBI-516580; Q8BWF2; Q07817-1: BCL2L1; Xeno; NbExp=3; IntAct=EBI-15572348, EBI-287195; Lysosome Lysosome membrane ; Single-pass type IV membrane protein Endosome, multivesicular body membrane ; Single-pass type IV membrane protein Endosome membrane ; Single-pass type IV membrane protein Expressed in thymus (in thymocytes), spleen (in splenocytes), lymph node and lung (PubMed:16509771). Highly expressed in T lymphocytes (PubMed:16509771, PubMed:21502331). Expressed in B cells and in distinct lineages of hematopoietic bone marrow cells, including natural killer, B, T, myeloid and erythroid lineages (PubMed:21502331). Expressed in liver endothelial cells (PubMed:33956074). Up-regulated upon the maturation of CD4/CD8 double-positive to CD4 single-positive thymocytes. Knockout mice are born at the expected Mendelian rate, with a normal sex ratio, but have a median survival of only 15 weeks. They exhibit chronic hepatic hematopoiesis and, in later stages, show pronounced hepatocyte apoptosis, leading to lethal liver failure. Loss of GIMAP5 function impairs peripheral T-cell survival, imposes a complete block of natural killer (NK) and NK T-cell development (PubMed:18796632). Mutant mice show progressive multilineage failure of bone marrow and hematopoiesis. Compared with that of wild-type counterparts, the bone marrow contains more hematopoietic stem cells, but fewer lineage-committed hematopoietic progenitors (PubMed:21502331). Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. nucleotide binding protein binding GTP binding mitochondrion lysosome lysosomal membrane endosome endosome membrane membrane integral component of membrane multivesicular body membrane uc009bvs.1 uc009bvs.2 uc009bvs.3 
ENSMUST00000055559.8 Ccdc126 ENSMUST00000055559.8 coiled-coil domain containing 126, transcript variant 1 (from RefSeq NM_175098.6) CC126_MOUSE ENSMUST00000055559.1 ENSMUST00000055559.2 ENSMUST00000055559.3 ENSMUST00000055559.4 ENSMUST00000055559.5 ENSMUST00000055559.6 ENSMUST00000055559.7 NM_175098 Q3TXH2 Q501L9 Q8BIS8 uc009bwp.1 uc009bwp.2 uc009bwp.3 uc009bwp.4 uc009bwp.5 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BIS8-1; Sequence=Displayed; Name=2; IsoId=Q8BIS8-2; Sequence=VSP_025785; extracellular region uc009bwp.1 uc009bwp.2 uc009bwp.3 uc009bwp.4 uc009bwp.5 
ENSMUST00000055562.3 Hoxc12 ENSMUST00000055562.3 homeobox C12 (from RefSeq NM_010463.2) ENSMUST00000055562.1 ENSMUST00000055562.2 HXC12_MOUSE Hox-3.8 Hoxc-12 NM_010463 Q8K5B8 uc007xww.1 uc007xww.2 uc007xww.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus Belongs to the Abd-B homeobox family. molecular_function DNA binding cellular_component nucleus regulation of transcription, DNA-templated multicellular organism development biological_process sequence-specific DNA binding uc007xww.1 uc007xww.2 uc007xww.3 
ENSMUST00000055575.8 Lsm10 ENSMUST00000055575.8 U7 snRNP-specific Sm-like protein LSM10, transcript variant 1 (from RefSeq NM_138721.3) ENSMUST00000055575.1 ENSMUST00000055575.2 ENSMUST00000055575.3 ENSMUST00000055575.4 ENSMUST00000055575.5 ENSMUST00000055575.6 ENSMUST00000055575.7 LSM10_MOUSE NM_138721 Q8QZX5 uc008usk.1 uc008usk.2 uc008usk.3 uc008usk.4 Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (By similarity). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to U7 snRNA (By similarity). Binds to the downstream cleavage product (DCP) of histone pre-mRNA. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP- dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN (By similarity). Nucleus Not methylated. Methylation is not necessary for interaction with SMN (By similarity). Belongs to the snRNP Sm proteins family. RNA binding nucleus U7 snRNP mRNA processing RNA splicing Cajal body nuclear body snRNA binding histone pre-mRNA DCP binding U7 snRNA binding positive regulation of G1/S transition of mitotic cell cycle uc008usk.1 uc008usk.2 uc008usk.3 uc008usk.4 
ENSMUST00000055604.6 Zfp526 ENSMUST00000055604.6 zinc finger protein 526 (from RefSeq NM_175436.5) ENSMUST00000055604.1 ENSMUST00000055604.2 ENSMUST00000055604.3 ENSMUST00000055604.4 ENSMUST00000055604.5 Kiaa1951 NM_175436 Q4VA17 Q69Z58 Q8BI66 Q8BIH7 ZN526_MOUSE Znf526 uc009frw.1 uc009frw.2 uc009frw.3 uc009frw.4 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BI66-1; Sequence=Displayed; Name=2; IsoId=Q8BI66-2; Sequence=VSP_028554, VSP_028555; Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC34772.1; Type=Frameshift; Evidence=; Sequence=BAD32586.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAD32586.1; Type=Miscellaneous discrepancy; Note=Partially unspliced pre-RNA.; Evidence=; nucleic acid binding DNA binding nucleus biological_process metal ion binding uc009frw.1 uc009frw.2 uc009frw.3 uc009frw.4 
ENSMUST00000055607.13 Ankdd1b ENSMUST00000055607.13 ankyrin repeat and death domain containing 1B, transcript variant 1 (from RefSeq NM_001369169.1) AKD1B_MOUSE ENSMUST00000055607.1 ENSMUST00000055607.10 ENSMUST00000055607.11 ENSMUST00000055607.12 ENSMUST00000055607.2 ENSMUST00000055607.3 ENSMUST00000055607.4 ENSMUST00000055607.5 ENSMUST00000055607.6 ENSMUST00000055607.7 ENSMUST00000055607.8 ENSMUST00000055607.9 NM_001369169 Q14DN9 Q8BZP7 uc007rmy.1 uc007rmy.2 uc007rmy.3 uc007rmy.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14DN9-1; Sequence=Displayed; Name=2; IsoId=Q14DN9-2; Sequence=VSP_046263; [Isoform 2]: Sequence identified by Havana. Sequence=AAI12418.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component signal transduction biological_process uc007rmy.1 uc007rmy.2 uc007rmy.3 uc007rmy.4 
ENSMUST00000055619.6 Hic1 ENSMUST00000055619.6 hypermethylated in cancer 1, transcript variant 1 (from RefSeq NM_010430.3) ENSMUST00000055619.1 ENSMUST00000055619.2 ENSMUST00000055619.3 ENSMUST00000055619.4 ENSMUST00000055619.5 Hic1 NM_010430 Z4YJP0 Z4YJP0_MOUSE uc007kdd.1 uc007kdd.2 uc007kdd.3 uc007kdd.4 Nucleus negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleoplasm cytosol intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of Wnt signaling pathway histone deacetylase binding sequence-specific DNA binding uc007kdd.1 uc007kdd.2 uc007kdd.3 uc007kdd.4 
ENSMUST00000055655.9 Fasn ENSMUST00000055655.9 fatty acid synthase (from RefSeq NM_007988.3) B1ATU8 ENSMUST00000055655.1 ENSMUST00000055655.2 ENSMUST00000055655.3 ENSMUST00000055655.4 ENSMUST00000055655.5 ENSMUST00000055655.6 ENSMUST00000055655.7 ENSMUST00000055655.8 FAS_MOUSE NM_007988 P19096 Q6PB72 Q8C4Z0 Q9EQR0 uc007mut.1 uc007mut.2 uc007mut.3 Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. Reaction=acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+); Xref=Rhea:RHEA:14993, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:57560, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=2.3.1.85; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14994; Evidence=; Reaction=acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA; Xref=Rhea:RHEA:41788, Rhea:RHEA-COMP:9621, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64479, ChEBI:CHEBI:78446; EC=2.3.1.38; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41789; Evidence=; Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]; Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449; EC=2.3.1.39; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41793; Evidence=; Reaction=a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:22836, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:9916, Rhea:RHEA-COMP:14125, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78776, ChEBI:CHEBI:138651; EC=2.3.1.41; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22837; Evidence=; Reaction=a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH; Xref=Rhea:RHEA:17397, Rhea:RHEA-COMP:9916, Rhea:RHEA- COMP:9945, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78776, ChEBI:CHEBI:78827; EC=1.1.1.100; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17399; Evidence=; Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O; Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945, ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13098; Evidence=; Reaction=a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH; Xref=Rhea:RHEA:22564, Rhea:RHEA-COMP:9925, Rhea:RHEA- COMP:9926, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78784, ChEBI:CHEBI:78785; EC=1.3.1.39; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22566; Evidence=; Reaction=H2O + hexadecanoyl-[ACP] = H(+) + hexadecanoate + holo-[ACP]; Xref=Rhea:RHEA:41932, Rhea:RHEA-COMP:9652, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64479, ChEBI:CHEBI:78483; EC=3.1.2.14; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41933; Evidence=; Reaction=acetyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41800, Rhea:RHEA-COMP:9621, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9625, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78446, ChEBI:CHEBI:78449, ChEBI:CHEBI:78450; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41801; Evidence=; Reaction=3-oxobutanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxybutanoyl- [ACP] + NADP(+); Xref=Rhea:RHEA:41804, Rhea:RHEA-COMP:9625, Rhea:RHEA-COMP:9626, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78450, ChEBI:CHEBI:78451; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41805; Evidence=; Reaction=(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41808, Rhea:RHEA-COMP:9626, Rhea:RHEA-COMP:9627, ChEBI:CHEBI:15377, ChEBI:CHEBI:78451, ChEBI:CHEBI:78453; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41809; Evidence=; Reaction=(2E)-butenoyl-[ACP] + H(+) + NADPH = butanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41812, Rhea:RHEA-COMP:9627, Rhea:RHEA-COMP:9628, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78453, ChEBI:CHEBI:78454; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41813; Evidence=; Reaction=butanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41820, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9628, Rhea:RHEA-COMP:9629, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78454, ChEBI:CHEBI:78456; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41821; Evidence=; Reaction=3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexanoyl- [ACP] + NADP(+); Xref=Rhea:RHEA:41824, Rhea:RHEA-COMP:9629, Rhea:RHEA-COMP:9630, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78456, ChEBI:CHEBI:78457; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41825; Evidence=; Reaction=(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41828, Rhea:RHEA-COMP:9630, Rhea:RHEA-COMP:9631, ChEBI:CHEBI:15377, ChEBI:CHEBI:78457, ChEBI:CHEBI:78458; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41829; Evidence=; Reaction=(2E)-hexenoyl-[ACP] + H(+) + NADPH = hexanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41832, Rhea:RHEA-COMP:9631, Rhea:RHEA-COMP:9632, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78458, ChEBI:CHEBI:78459; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41833; Evidence=; Reaction=H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41836, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9632, Rhea:RHEA-COMP:9633, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78459, ChEBI:CHEBI:78460; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41837; Evidence=; Reaction=3-oxooctanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctanoyl- [ACP] + NADP(+); Xref=Rhea:RHEA:41840, Rhea:RHEA-COMP:9633, Rhea:RHEA-COMP:9634, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78460, ChEBI:CHEBI:78461; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41841; Evidence=; Reaction=(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41844, Rhea:RHEA-COMP:9634, Rhea:RHEA-COMP:9635, ChEBI:CHEBI:15377, ChEBI:CHEBI:78461, ChEBI:CHEBI:78462; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41845; Evidence=; Reaction=(2E)-octenoyl-[ACP] + H(+) + NADPH = NADP(+) + octanoyl-[ACP]; Xref=Rhea:RHEA:41848, Rhea:RHEA-COMP:9635, Rhea:RHEA-COMP:9636, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78462, ChEBI:CHEBI:78463; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41849; Evidence=; Reaction=H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41852, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9636, Rhea:RHEA-COMP:9637, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78463, ChEBI:CHEBI:78464; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41853; Evidence=; Reaction=3-oxodecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydecanoyl- [ACP] + NADP(+); Xref=Rhea:RHEA:41856, Rhea:RHEA-COMP:9637, Rhea:RHEA-COMP:9638, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78464, ChEBI:CHEBI:78466; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41857; Evidence=; Reaction=(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41860, Rhea:RHEA-COMP:9638, Rhea:RHEA-COMP:9639, ChEBI:CHEBI:15377, ChEBI:CHEBI:78466, ChEBI:CHEBI:78467; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41861; Evidence=; Reaction=(2E)-decenoyl-[ACP] + H(+) + NADPH = decanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41864, Rhea:RHEA-COMP:9639, Rhea:RHEA-COMP:9640, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78467, ChEBI:CHEBI:78468; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41865; Evidence=; Reaction=decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41868, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9640, Rhea:RHEA-COMP:9641, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78468, ChEBI:CHEBI:78469; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41869; Evidence=; Reaction=3-oxododecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydodecanoyl- [ACP] + NADP(+); Xref=Rhea:RHEA:41872, Rhea:RHEA-COMP:9641, Rhea:RHEA-COMP:9642, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78469, ChEBI:CHEBI:78470; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41873; Evidence=; Reaction=(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41876, Rhea:RHEA-COMP:9642, Rhea:RHEA-COMP:9643, ChEBI:CHEBI:15377, ChEBI:CHEBI:78470, ChEBI:CHEBI:78472; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41877; Evidence=; Reaction=(2E)-dodecenoyl-[ACP] + H(+) + NADPH = dodecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41880, Rhea:RHEA-COMP:9643, Rhea:RHEA- COMP:9644, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:65264, ChEBI:CHEBI:78472; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41881; Evidence=; Reaction=dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl- [ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41884, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9644, Rhea:RHEA-COMP:9645, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:65264, ChEBI:CHEBI:78449, ChEBI:CHEBI:78473; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41885; Evidence=; Reaction=3-oxotetradecanoyl-[ACP] + H(+) + NADPH = (3R)- hydroxytetradecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41888, Rhea:RHEA-COMP:9645, Rhea:RHEA-COMP:9646, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78473, ChEBI:CHEBI:78474; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41889; Evidence=; Reaction=(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41892, Rhea:RHEA-COMP:9646, Rhea:RHEA-COMP:9647, ChEBI:CHEBI:15377, ChEBI:CHEBI:78474, ChEBI:CHEBI:78475; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41893; Evidence=; Reaction=(2E)-tetradecenoyl-[ACP] + H(+) + NADPH = NADP(+) + tetradecanoyl-[ACP]; Xref=Rhea:RHEA:41896, Rhea:RHEA-COMP:9647, Rhea:RHEA-COMP:9648, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78475, ChEBI:CHEBI:78477; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41897; Evidence=; Reaction=H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3- oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41900, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9648, Rhea:RHEA-COMP:9649, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78477, ChEBI:CHEBI:78478; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41901; Evidence=; Reaction=3-oxohexadecanoyl-[ACP] + H(+) + NADPH = (3R)- hydroxyhexadecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41904, Rhea:RHEA- COMP:9649, Rhea:RHEA-COMP:9650, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78478, ChEBI:CHEBI:78480; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41905; Evidence=; Reaction=(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41908, Rhea:RHEA-COMP:9650, Rhea:RHEA-COMP:9651, ChEBI:CHEBI:15377, ChEBI:CHEBI:78480, ChEBI:CHEBI:78481; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41909; Evidence=; Reaction=(2E)-hexadecenoyl-[ACP] + H(+) + NADPH = hexadecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41912, Rhea:RHEA-COMP:9651, Rhea:RHEA- COMP:9652, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78481, ChEBI:CHEBI:78483; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41913; Evidence=; Reaction=H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl- [ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41916, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9652, Rhea:RHEA-COMP:9653, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78483, ChEBI:CHEBI:78487; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41917; Evidence=; Reaction=3-oxooctadecanoyl-[ACP] + H(+) + NADPH = (3R)- hydroxyoctadecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41920, Rhea:RHEA- COMP:9653, Rhea:RHEA-COMP:9654, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78487, ChEBI:CHEBI:78488; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41921; Evidence=; Reaction=(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41924, Rhea:RHEA-COMP:9654, Rhea:RHEA-COMP:9655, ChEBI:CHEBI:15377, ChEBI:CHEBI:78488, ChEBI:CHEBI:78489; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41925; Evidence=; Reaction=(2E)-octadecenoyl-[ACP] + H(+) + NADPH = NADP(+) + octadecanoyl-[ACP]; Xref=Rhea:RHEA:41928, Rhea:RHEA-COMP:9655, Rhea:RHEA-COMP:9656, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78489, ChEBI:CHEBI:78495; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41929; Evidence=; Reaction=H2O + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + tetradecanoate; Xref=Rhea:RHEA:30123, Rhea:RHEA-COMP:9648, Rhea:RHEA- COMP:9685, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:64479, ChEBI:CHEBI:78477; EC=3.1.2.14; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30124; Evidence=; Kinetic parameters: KM=1.28 uM for malonyl-CoA ; KM=1.63 uM for acetyl-CoA ; Lipid metabolism; fatty acid biosynthesis. Homodimer which is arranged in a head to tail fashion (By similarity). Interacts with CEACAM1; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity (By similarity). Cytoplasm Melanosome Up-regulated by endocannabinoid anandamide/AEA. S-nitrosylation of Fatty acid synthase at cysteine residues Cys- 1464 or Cys-2084 is important for the enzyme dimerization. In adipocytes, S-nitrosylation of Fatty acid synthase occurs under physiological conditions and gradually increases during adipogenesis. Sequence=CAA31525.1; Type=Frameshift; Evidence=; catalytic activity fatty acid synthase activity [acyl-carrier-protein] S-acetyltransferase activity [acyl-carrier-protein] S-malonyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity oleoyl-[acyl-carrier-protein] hydrolase activity cytoplasm mitochondrion Golgi apparatus cytosol plasma membrane acetyl-CoA metabolic process lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process drug binding metabolic process ether lipid biosynthetic process (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity biosynthetic process tissue development myristoyl-[acyl-carrier-protein] hydrolase activity palmitoyl-[acyl-carrier-protein] hydrolase activity acyl-[acyl-carrier-protein] hydrolase activity S-acetyltransferase activity S-malonyltransferase activity oxidoreductase activity transferase activity hydrolase activity hydrolase activity, acting on ester bonds lyase activity 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity neutrophil differentiation monocyte differentiation mammary gland development phosphopantetheine binding melanosome glycogen granule identical protein binding protein homodimerization activity enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity cell development oxidation-reduction process NADPH binding cellular response to interleukin-4 establishment of endothelial intestinal barrier 3-oxo-pimeloyl-[acp] methyl ester reductase activity uc007mut.1 uc007mut.2 uc007mut.3 
ENSMUST00000055662.4 Lrtm1 ENSMUST00000055662.4 leucine-rich repeats and transmembrane domains 1 (from RefSeq NM_176920.4) ENSMUST00000055662.1 ENSMUST00000055662.2 ENSMUST00000055662.3 LRTM1_MOUSE NM_176920 Q8BXQ3 uc007suj.1 uc007suj.2 uc007suj.3 uc007suj.4 Membrane ; Single-pass type I membrane protein It is uncertain whether Met-1 or Met-13 is the initiator. axon guidance heparin binding membrane integral component of membrane Roundabout binding negative chemotaxis positive regulation of synapse assembly uc007suj.1 uc007suj.2 uc007suj.3 uc007suj.4 
ENSMUST00000055671.5 Ifnb1 ENSMUST00000055671.5 interferon beta 1, fibroblast (from RefSeq NM_010510.2) ENSMUST00000055671.1 ENSMUST00000055671.2 ENSMUST00000055671.3 ENSMUST00000055671.4 If1da1 Ifnb1 NM_010510 Q0VE17 Q0VE17_MOUSE uc008tmz.1 uc008tmz.2 uc008tmz.3 Monomer. Belongs to the alpha/beta interferon family. cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response signal transduction defense response to virus uc008tmz.1 uc008tmz.2 uc008tmz.3 
ENSMUST00000055676.4 S1pr1 ENSMUST00000055676.4 sphingosine-1-phosphate receptor 1 (from RefSeq NM_007901.5) ENSMUST00000055676.1 ENSMUST00000055676.2 ENSMUST00000055676.3 Edg1 Lpb1 NM_007901 O08530 Q9DC35 Q9R235 S1PR1_MOUSE S1pr1 uc008rbo.1 uc008rbo.2 uc008rbo.3 uc008rbo.4 This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK004591.2, AK138316.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator- induced lung injury. Interacts with GNAI1 and GNAI3. Cell membrane; Multi-pass membrane protein. Endosome Membrane, caveola Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization (By similarity). Expressed in a wide variety of tissues with highest levels in brain, heart and spleen. Lower levels found in kidney, liver, lung, muscle, placenta, thymus, and uterus. Very low levels in intestine, stomach and testis. According to PubMed:9931453, expressed modestly in apparent endothelial cells surrounding some blood vessels (e.g. aortic trunk). Palmitoylated by ZDHHC5. Palmitoylation is required for targeting to plasma membrane, enabling G(i) coupling. Embryonic lethality, due to impaired vascular maturation and defects in heart development. Embryos appear normal up to 11.5 dpc, but after that they display massive hemorrhage. They have a normally arborized vascular network, but present excessive sprouting angiogenesis and severe aberrations in vessel size. Their aorta and other arteries are not properly enveloped by vascular smooth muscle cells, causing hemorrhage. Likewise, small blood vessels show a marked reduction in the number of vascular pericytes. In addition, mutants display defects in heart morphogenesis, with reduced myocardial tissue and altered morphology of the heart wall and the trabeculae (PubMed:11032855, PubMed:14732704, PubMed:21668976, PubMed:22951644). At 12.5 dpc, mutant embryos also show a massive cell loss in the forebrain (PubMed:16314531). Conditional knockout in endothelial cells leads to the same vascular maturation defect as that seen in homozygous knockout mice (PubMed:12869509). Conditional knockout in fibroblasts leads to defects in chemotaxis, probably due to defects in the activation of SRC and PTK2/FAK1, resulting in defects in the reorganization of the actin cytoskeleton and lamellipodia formation (PubMed:11726541). A T-cell-specific knockout leads to a defect in the egress of mature T-cells from the thymus into the periphery (PubMed:14737169). Conditional knockout in osteoclast precursors leads to osteoporosis, due to impaired migration of osteoclast precursors and increased osteoclast attachment to the bone (PubMed:19204730). Belongs to the G-protein coupled receptor 1 family. angiogenesis G-protein coupled receptor binding blood vessel maturation cardiac muscle tissue growth involved in heart morphogenesis sphingosine-1-phosphate signaling pathway G-protein coupled receptor activity nucleoplasm endosome plasma membrane caveola chemotaxis signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway brain development positive regulation of cell proliferation external side of plasma membrane membrane integral component of membrane cell migration transmission of nerve impulse lamellipodium assembly regulation of cell adhesion neuron differentiation positive regulation of cell migration regulation of bone mineralization leukocyte chemotaxis intrinsic component of plasma membrane actin cytoskeleton reorganization sphingosine-1-phosphate receptor activity intracellular membrane-bounded organelle positive regulation of GTPase activity regulation of bone resorption endothelial cell differentiation positive regulation of transcription from RNA polymerase II promoter sphingolipid binding positive regulation of smooth muscle cell proliferation positive regulation of positive chemotaxis positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway negative regulation of stress fiber assembly heart trabecula morphogenesis T cell migration uc008rbo.1 uc008rbo.2 uc008rbo.3 uc008rbo.4 
ENSMUST00000055688.10 Phf13 ENSMUST00000055688.10 PHD finger protein 13 (from RefSeq NM_172705.2) ENSMUST00000055688.1 ENSMUST00000055688.2 ENSMUST00000055688.3 ENSMUST00000055688.4 ENSMUST00000055688.5 ENSMUST00000055688.6 ENSMUST00000055688.7 ENSMUST00000055688.8 ENSMUST00000055688.9 NM_172705 PHF13_MOUSE Q8K2W6 uc008vyx.1 uc008vyx.2 uc008vyx.3 uc008vyx.4 Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response. Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation (By similarity). Essential for testicular stem-cell differentiation and sustained spermatogenesis (PubMed:21852425). Interacts with histone H3 that is trimethylated at 'Lys-4' (H3K4me3). Interacts with GSK3B. Interacts with TRIM28. Interacts with SETDB1; the interaction probably enhances SETDB1 chromatin-associated levels and activity. Nucleus Nucleus, nucleoplasm Note=Predominantly bound to chromatin, but a minor proportion is also detected in the nucleoplasm. Subject to proteasomal degradation. Stable when bound to chromatin. The soluble form is rapidly degraded. Knockout mice are indistinguishable from wild- type littermates on the basis of appearance and breeding capacity. They have smaller testes and a reduced number of germ cells. Postpubertal homozygous mutant animals display a pronounced progressive loss of germ cells from an initially normal germ epithelium of the testis tubules leading to testis hypoplasia and early infertility. mitotic cell cycle chromatin binding nucleus nucleoplasm chromatin organization cell cycle chromosome segregation mitotic chromosome condensation chromosome condensation metal ion binding cell division uc008vyx.1 uc008vyx.2 uc008vyx.3 uc008vyx.4 
ENSMUST00000055693.9 Cyp2j9 ENSMUST00000055693.9 cytochrome P450, family 2, subfamily j, polypeptide 9, transcript variant 1 (from RefSeq NM_028979.3) Cyp2j9 ENSMUST00000055693.1 ENSMUST00000055693.2 ENSMUST00000055693.3 ENSMUST00000055693.4 ENSMUST00000055693.5 ENSMUST00000055693.6 ENSMUST00000055693.7 ENSMUST00000055693.8 NM_028979 Q924D1 Q924D1_MOUSE uc008ttj.1 uc008ttj.2 uc008ttj.3 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc008ttj.1 uc008ttj.2 uc008ttj.3 
ENSMUST00000055698.8 Gjb2 ENSMUST00000055698.8 gap junction protein, beta 2 (from RefSeq NM_008125.3) ENSMUST00000055698.1 ENSMUST00000055698.2 ENSMUST00000055698.3 ENSMUST00000055698.4 ENSMUST00000055698.5 ENSMUST00000055698.6 ENSMUST00000055698.7 Gjb2 NM_008125 Q3UJE9 Q3UJE9_MOUSE uc007ucx.1 uc007ucx.2 uc007ucx.3 uc007ucx.4 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Cell junction, gap junction Cell membrane ; Multi- pass membrane protein mbrane ; Multi-pass membrane protein Belongs to the connexin family. Beta-type (group I) subfamily. response to ischemia gap junction channel activity calcium ion binding cytoplasm cytosol plasma membrane integral component of plasma membrane gap junction connexin complex cell communication female pregnancy aging cell communication by electrical coupling membrane integral component of membrane gap junction assembly lateral plasma membrane cell junction response to estradiol response to lipopolysaccharide response to retinoic acid response to progesterone cellular response to oxidative stress identical protein binding cell body response to human chorionic gonadotropin response to antibiotic decidualization perinuclear region of cytoplasm inner ear development transmembrane transport cellular response to glucagon stimulus cellular response to dexamethasone stimulus astrocyte projection gap junction channel activity involved in cell communication by electrical coupling gap junction-mediated intercellular transport uc007ucx.1 uc007ucx.2 uc007ucx.3 uc007ucx.4 
ENSMUST00000055704.12 Gnai2 ENSMUST00000055704.12 G protein subunit alpha i2, transcript variant 1 (from RefSeq NM_008138.5) ENSMUST00000055704.1 ENSMUST00000055704.10 ENSMUST00000055704.11 ENSMUST00000055704.2 ENSMUST00000055704.3 ENSMUST00000055704.4 ENSMUST00000055704.5 ENSMUST00000055704.6 ENSMUST00000055704.7 ENSMUST00000055704.8 ENSMUST00000055704.9 GNAI2_MOUSE Gnai-2 NM_008138 P08752 Q3TXK7 Q6P1C0 uc009rml.1 uc009rml.2 uc009rml.3 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. In this context, interacts with GNB2 (By similarity). Interacts with UNC5B (By similarity). Interacts with GPSM1 (By similarity). Interacts with RGS12 and RGS14 (By similarity). Interacts (inactive GDP-bound form) with NUCB1 (via GBA motif); the interaction leads to activation of GNAI3 (By similarity). Interacts (inactive GDP-bound form) with CCDC88C/DAPLE (via GBA motif) (By similarity). Interacts (inactive GDP-bound form) with CCDC8A/GIV (via GBA motif) (By similarity). Interacts with CXCR1 and CXCR2 (By similarity). Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cell membrane Membrane ; Lipid-anchor Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. nucleotide binding G-protein coupled receptor binding adenosine receptor signaling pathway GTPase activity protein binding GTP binding nucleus nucleoplasm cytoplasm centrosome microtubule organizing center cytosol heterotrimeric G-protein complex cytoskeleton plasma membrane cell cycle signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway G-protein coupled acetylcholine receptor signaling pathway gamma-aminobutyric acid signaling pathway cell proliferation positive regulation of cell proliferation membrane guanyl nucleotide binding positive regulation of cell migration dendrite midbody G-protein beta/gamma-subunit complex binding positive regulation of superoxide anion generation positive regulation of NAD(P)H oxidase activity positive regulation of urine volume positive regulation of renal sodium excretion cell body membrane raft negative regulation of calcium ion-dependent exocytosis positive regulation of insulin receptor signaling pathway metal ion binding negative regulation of synaptic transmission cell division regulation of calcium ion transport positive regulation of ERK1 and ERK2 cascade negative regulation of protein tyrosine phosphatase activity positive regulation of vascular smooth muscle cell proliferation positive regulation of neural precursor cell proliferation negative regulation of apoptotic signaling pathway regulation of heart contraction uc009rml.1 uc009rml.2 uc009rml.3 
ENSMUST00000055719.8 Ly6g2 ENSMUST00000055719.8 lymphocyte antigen 6 family member G2, transcript variant 5 (from RefSeq NM_001416438.1) BC025446 ENSMUST00000055719.1 ENSMUST00000055719.2 ENSMUST00000055719.3 ENSMUST00000055719.4 ENSMUST00000055719.5 ENSMUST00000055719.6 ENSMUST00000055719.7 Ly6g2 NM_001416438 Q8R155 Q8R155_MOUSE uc007wgr.1 uc007wgr.2 uc007wgr.3 uc007wgr.4 cellular_component acetylcholine receptor inhibitor activity acetylcholine receptor binding acetylcholine receptor signaling pathway negative regulation of receptor activity uc007wgr.1 uc007wgr.2 uc007wgr.3 uc007wgr.4 
ENSMUST00000055721.6 Cyp2d40 ENSMUST00000055721.6 cytochrome P450, family 2, subfamily d, polypeptide 40 (from RefSeq NM_023623.2) Cyp2d40 ENSMUST00000055721.1 ENSMUST00000055721.2 ENSMUST00000055721.3 ENSMUST00000055721.4 ENSMUST00000055721.5 NM_023623 Q6P8N9 Q6P8N9_MOUSE uc007wzm.1 uc007wzm.2 uc007wzm.3 Microsome membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc007wzm.1 uc007wzm.2 uc007wzm.3 
ENSMUST00000055723.9 Tnfrsf26 ENSMUST00000055723.9 tumor necrosis factor receptor superfamily, member 26 (from RefSeq NM_175649.5) ENSMUST00000055723.1 ENSMUST00000055723.2 ENSMUST00000055723.3 ENSMUST00000055723.4 ENSMUST00000055723.5 ENSMUST00000055723.6 ENSMUST00000055723.7 ENSMUST00000055723.8 NM_175649 Q3U3N2 Q3U3N2_MOUSE Tnfrsf26 uc009kpp.1 uc009kpp.2 uc009kpp.3 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc009kpp.1 uc009kpp.2 uc009kpp.3 
ENSMUST00000055725.12 Spink10 ENSMUST00000055725.12 serine peptidase inhibitor, Kazal type 10 (from RefSeq NM_177829.3) ENSMUST00000055725.1 ENSMUST00000055725.10 ENSMUST00000055725.11 ENSMUST00000055725.2 ENSMUST00000055725.3 ENSMUST00000055725.4 ENSMUST00000055725.5 ENSMUST00000055725.6 ENSMUST00000055725.7 ENSMUST00000055725.8 ENSMUST00000055725.9 ISK10_MOUSE NM_177829 Q8CAC8 uc008fdf.1 uc008fdf.2 uc008fdf.3 uc008fdf.4 Probable serine protease inhibitor. Membrane ; Multi-pass membrane protein Expressed in epydiymis, in the cauda and corpus. Also expressed in brain. serine-type endopeptidase inhibitor activity negative regulation of peptidase activity negative regulation of endopeptidase activity membrane integral component of membrane peptidase inhibitor activity uc008fdf.1 uc008fdf.2 uc008fdf.3 uc008fdf.4 
ENSMUST00000055738.12 Tsc22d3 ENSMUST00000055738.12 TSC22 domain family, member 3, transcript variant 2 (from RefSeq NM_010286.6) B1AVF3 C6EX03 Dsip1 Dsipi ENSMUST00000055738.1 ENSMUST00000055738.10 ENSMUST00000055738.11 ENSMUST00000055738.2 ENSMUST00000055738.3 ENSMUST00000055738.4 ENSMUST00000055738.5 ENSMUST00000055738.6 ENSMUST00000055738.7 ENSMUST00000055738.8 ENSMUST00000055738.9 Gilz NM_010286 Q3UNI6 Q8K160 Q9EQN0 Q9EQN1 Q9EQN2 Q9Z2S7 T22D3_MOUSE Tsc22d3 uc009ula.1 uc009ula.2 uc009ula.3 uc009ula.4 Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:26752201). In macrophages, plays a role in the anti- inflammatory and immunosuppressive effects of glucocorticoids and IL10 (By similarity). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (By similarity). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (PubMed:11397794). [Isoform 1]: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. [Isoform 4]: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. Can form homodimers, however it is likely to function as a monomer (PubMed:11397794). Interacts with NFKB1 (By similarity). Interacts (via N-terminus) with JUN and FOS; these interactions inhibit the binding of active AP1 to its target DNA (PubMed:11397794). [Isoform 1]: Interacts with MYOD1 (PubMed:20124407). Interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity (PubMed:20124407). [Isoform 4]: Interacts with MYOD1. Q9Z2S7-3; Q8CFI0: Nedd4l; NbExp=2; IntAct=EBI-15771036, EBI-8046183; Q9Z2S7-3; Q99N57: Raf1; NbExp=2; IntAct=EBI-15771036, EBI-397757; Q9Z2S7-3; Q9WVC6: Sgk1; NbExp=2; IntAct=EBI-15771036, EBI-15591730; [Isoform 1]: Cytoplasm Nucleus Note=Localization depends on differentiation status of myoblasts (PubMed:20124407). In undifferentiated myoblasts; localizes to the cytoplasm, but in differentiating myoblast; localizes to the nucleus (PubMed:20124407). [Isoform 4]: Cytoplasm Nucleus Note=Localization depends on differentiation status of myoblasts (PubMed:20124407). In undifferentiated myoblasts; localizes to the cytoplasm, but in differentiating myoblasts; localizes to the nucleus (PubMed:20124407). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Tilz3b, TSC22D3-2 ; IsoId=Q9Z2S7-1; Sequence=Displayed; Name=2; Synonyms=Tilz3a; IsoId=Q9Z2S7-2; Sequence=VSP_012690; Name=3; Synonyms=Tilz3c, TSC22D3-1 ; IsoId=Q9Z2S7-3; Sequence=VSP_012691; Name=4; Synonyms=Long Gilz, L-Gilz; IsoId=Q9Z2S7-4; Sequence=VSP_055016; Expressed in T-cells (PubMed:26752201). Expression inversely correlates with T-cell activation, being higher in resting cells and lower in cells activated by TCR/CD3 triggering (at protein level) (PubMed:11468175). Constitutively expressed in lung, intestine, kidney and liver, most probably by resident cells from the macrophage lineage (PubMed:12393603). Expressed in thymus, lymph nodes, bone marrow, spleen, lung and skeletal muscle (PubMed:9430225). [Isoform 1]: Expressed in spleen and skeletal muscle (at protein level) (PubMed:20124407). Expressed in the cortex, medulla and papilla of the kidney (PubMed:17147695). [Isoform 3]: Expressed in the cortex, medulla and papilla of the kidney. [Isoform 4]: Expressed in spleen and skeletal muscle (at protein level). [Isoform 1]: Expressed in differentiating myoblasts at a time of myotube formation. [Isoform 4]: Expressed in differentiating myoblasts at a time of myotube formation. Induced by dexamethasone in lymphoid cells (PubMed:9430225, PubMed:12393603). Induced by Il4, Il10 and Il13 expression in monocyte/macrophage cells (PubMed:12393603). Transiently induced by Il2 deprivation in T-cells. [Isoform 1]: Induced by renal hyperosmotic stress and aldosterone (PubMed:17147695). Induced by the synthetic glucocorticoid dexamethasone in differentiating myoblasts (PubMed:20124407). [Isoform 3]: Induced by aldosterone. [Isoform 4]: Induced by the synthetic glucocorticoid dexamethasone in differentiating myoblasts. The leucine-zipper is involved in homodimerization. Belongs to the TSC-22/Dip/Bun family. negative regulation of transcription from RNA polymerase II promoter transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated response to osmotic stress MRF binding negative regulation of skeletal muscle tissue development negative regulation of activation-induced cell death of T cells uc009ula.1 uc009ula.2 uc009ula.3 uc009ula.4 
ENSMUST00000055745.5 Nlrp10 ENSMUST00000055745.5 NLR family, pyrin domain containing 10 (from RefSeq NM_175532.3) ENSMUST00000055745.1 ENSMUST00000055745.2 ENSMUST00000055745.3 ENSMUST00000055745.4 NAL10_MOUSE NM_175532 Nalp10 Pynod Q8CCN1 uc009jdb.1 uc009jdb.2 uc009jdb.3 Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (By similarity). Displays anti- inflammatory activity (By similarity). Required for immunity against C.albicans infection (PubMed:23071280). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (By similarity). Contributes to T-cell-mediated inflammatory responses in the skin (PubMed:27221772). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (By similarity). Exhibits both ATPase and GTPase activities (By similarity). Oligomerizes (By similarity). Interacts with PYCARD (By similarity). Also interacts with CASP1 and IL1B (PubMed:15096476). Interacts with NOD1 and components of the NOD1 signaling pathway including RIPK2, NR2C2/TAK1 and IKBKG/NEMO (By similarity). Cytoplasm Cell membrane ; Peripheral membrane protein Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection. Expressed in skin, tongue, heart, colon and several cell lines of hematopoietic and myocytic origin but not in kidney, skeletal muscle, spleen, liver, lung, thymus, brain or small intestine (at protein level). The pyrin and ATP-binding domains are required to elicit cytokine release following bacterial infection. The NACHT domain is required for inhibition of CASP1 autoprocessing. High susceptibility to systemic infection by C.albicans with 100% mortality by day 16 post-infection (PubMed:23071280). Does not alter Nlrp3 inflammasome activity and up- regulates Gdpd3 expression (PubMed:22538615). Does not impair skin repair after wounding (PubMed:27221772). Also does not impair the irritant contact dermatitis response following treatment with the irritant croton oil (PubMed:27221772). Significantly reduced inflammation in dinitrofluorobenzene-induced contact hypersensitivity response with reduced numbers of CD3(+), CD8(+) and CD4(+) T cells (PubMed:27221772). Belongs to the NLRP family. Despite its official name, does not contain LRR repeats. Was originally thought to play a role in adaptive immunity through control of dendritic cell-mediated antigen transport to lymph nodes from peripheral sites (PubMed:22538615). However, this was later shown to be dependent on DOCK8 (PubMed:26605525). nucleotide binding adaptive immune response immune system process positive regulation of T-helper 1 type immune response GTPase activity ATP binding cytoplasm plasma membrane defense response inflammatory response membrane ATPase activity extrinsic component of plasma membrane innate immune response positive regulation of interleukin-1 alpha secretion positive regulation of inflammatory response defense response to Gram-negative bacterium defense response to fungus positive regulation of defense response to bacterium positive regulation of T-helper 17 type immune response positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion uc009jdb.1 uc009jdb.2 uc009jdb.3 
ENSMUST00000055758.16 Ubr3 ENSMUST00000055758.16 ubiquitin protein ligase E3 component n-recognin 3, transcript variant 2 (from RefSeq NM_177783.6) A2AV04 A6MFP4 ENSMUST00000055758.1 ENSMUST00000055758.10 ENSMUST00000055758.11 ENSMUST00000055758.12 ENSMUST00000055758.13 ENSMUST00000055758.14 ENSMUST00000055758.15 ENSMUST00000055758.2 ENSMUST00000055758.3 ENSMUST00000055758.4 ENSMUST00000055758.5 ENSMUST00000055758.6 ENSMUST00000055758.7 ENSMUST00000055758.8 ENSMUST00000055758.9 Kiaa2024 NM_177783 Q5U430 Q69Z32 UBR3_MOUSE Zfp650 Znf650 uc008jzb.1 uc008jzb.2 uc008jzb.3 uc008jzb.4 uc008jzb.5 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:17462990). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N- end rule, leading to their ubiquitination and subsequent degradation (PubMed:17462990). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (PubMed:27195754). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with UBE2A and UBE2B. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5U430-1; Sequence=Displayed; Name=2; IsoId=Q5U430-2; Sequence=VSP_023143; Name=3; IsoId=Q5U430-3; Sequence=VSP_023144, VSP_023145; Expressed in numerous cells of the smell, touch, vision, hearing and taste senses. Expressed in cells of the olfactory pathway, including the olfactory cell layer of the main olfactory epithelium (MOE), a mitral neuron cell layer of the olfactory bulb (OB), and a pyramidal cell layer of the piriform cortex of the olfactory cortex (OC). Expressed in the vomeronasal sensory epithelium of the vomeronasal organ (VNO) and the mitral cells of the accessory olfactory bulb. Expressed in tactile tissues, including the dorsal root ganglion, trigeminal ganglion and follicle-sinus complexes. Expressed in cells between hair follicle and sinus and also in the region of the rete ridge collar. Expressed in taste buds of the fungiform, circumvallate, and foliate papillae. Expressed in the spiral ganglion, the organ of Corti of the cochlea in the inner ear, in the sensory epithelium of macula and vestibular ganglion of the balancing system (at protein level). Expressed in the liver and skeletal muscle. Knockout mice for Ubr3 in a B6-enriched background exhibited neonatal lethality associated with suckling impairment, but can be partially rescued if the litter size is reduced. Survived adult knockout mice for Ubr3 had female-specific behavioral anosmia (decreased sense of smell). Belongs to the UBR1 family. ubiquitin ligase complex in utero embryonic development suckling behavior ubiquitin-protein transferase activity protein binding cytoplasm ubiquitin-dependent protein catabolic process sensory perception of smell zinc ion binding embryo development ending in birth or egg hatching membrane integral component of membrane protein ubiquitination transferase activity olfactory behavior metal ion binding ubiquitin protein ligase activity ubiquitin-dependent protein catabolic process via the N-end rule pathway uc008jzb.1 uc008jzb.2 uc008jzb.3 uc008jzb.4 uc008jzb.5 
ENSMUST00000055770.4 H1f1 ENSMUST00000055770.4 H1.1 linker histone, cluster member (from RefSeq NM_030609.3) ENSMUST00000055770.1 ENSMUST00000055770.2 ENSMUST00000055770.3 H1-1 H11_MOUSE H1a H1f1 Hist1h1a NM_030609 P43275 Q5SZ98 uc007puz.1 uc007puz.2 uc007puz.3 uc007puz.4 Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Interacts with DFFB. Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Restricted to thymus, testis and spleen. Present also in lymphocytic and neuronal cells. Increases in testis starting with a low level at day 5 and reaching high concentrations in 20-day old and adult animals. The C-terminal domain is required for high-affinity binding to chromatin. H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Hydroxybutyrylation of histones is induced by starvation. Deficient-mice developed normally until the adult stage. No anatomic abnormalities are detected, mice are fertile and they show normal spermatogenesis and testicular morphology. The lack of phenotype may be due to a compensatory function of other histone H1 subtypes. Belongs to the histone H1/H5 family. nucleosome nuclear chromatin DNA binding double-stranded DNA binding protein binding nucleus chromosome nuclear euchromatin nucleosome assembly regulation of transcription, DNA-templated spermatogenesis heparin binding cell surface nucleosome positioning chromosome condensation chromatin DNA binding nucleosomal DNA binding negative regulation of chromatin silencing vesicle negative regulation of DNA recombination positive regulation of receptor-mediated endocytosis uc007puz.1 uc007puz.2 uc007puz.3 uc007puz.4 
ENSMUST00000055776.8 Arhgap15 ENSMUST00000055776.8 Rho GTPase activating protein 15, transcript variant 1 (from RefSeq NM_153820.3) ENSMUST00000055776.1 ENSMUST00000055776.2 ENSMUST00000055776.3 ENSMUST00000055776.4 ENSMUST00000055776.5 ENSMUST00000055776.6 ENSMUST00000055776.7 NM_153820 Q3T9M8 Q3TCU0 Q811M1 Q8C0I5 Q8JZY0 RHG15_MOUSE uc008jow.1 uc008jow.2 uc008jow.3 The protein encoded by this gene is a RAC GTPase-activating protein that is regulated through its PH domain and by recruitment to the membrane. The protein accelerates hydrolysis of guanosine triphosphate to guanosine diphosphate to repress Rac activity. Knock-out of Arhgap15 function demonstrates that this gene is required to regulate multiple functions in macrophages and neutrophils. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity). Cytoplasm Membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q811M1-1; Sequence=Displayed; Name=2; IsoId=Q811M1-2; Sequence=VSP_031051, VSP_031052; Name=3; IsoId=Q811M1-3; Sequence=VSP_031049, VSP_031050; Name=4; IsoId=Q811M1-4; Sequence=VSP_031048; The PH domain is required for localization to the membrane. Sequence=AAH34881.1; Type=Erroneous initiation; Evidence=; GTPase activator activity cytoplasm signal transduction regulation of cell shape membrane regulation of GTPase activity positive regulation of GTPase activity uc008jow.1 uc008jow.2 uc008jow.3 
ENSMUST00000055808.6 Ywhag ENSMUST00000055808.6 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide (from RefSeq NM_018871.3) 1433G_MOUSE ENSMUST00000055808.1 ENSMUST00000055808.2 ENSMUST00000055808.3 ENSMUST00000055808.4 ENSMUST00000055808.5 NM_018871 O70457 P35214 P61982 Q3UFD6 Q4FK44 Q9UDP2 Q9UN99 uc008zzf.1 uc008zzf.2 uc008zzf.3 uc008zzf.4 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24. Homodimer (By similarity). Interacts with SAMSN1 (PubMed:20478393). Interacts with RAF1, SSH1 and CRTC2/TORC2 (By similarity). Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with GAB2 (By similarity). Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53 (By similarity). Interacts with PKA- phosphorylated AANAT and SIRT2 (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with SLITRK1 (By similarity). Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (By similarity). Interacts with MARK2 and MARK3 (By similarity). Interacts with MEFV (By similarity). Interacts with ENDOG, TSC2 and PIK3C3; interaction with ENDOG weakens its interaction with TSC2 and PIK3C3 (By similarity). Interacts with (phosphorylated) WDR24 (By similarity). P61982; Q08460: Kcnma1; NbExp=4; IntAct=EBI-359843, EBI-1633915; P61982; Q5S006: Lrrk2; NbExp=10; IntAct=EBI-359843, EBI-2693710; Cytoplasm Phosphorylated by various PKC isozymes. Belongs to the 14-3-3 family. Sequence=BAE28625.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; actin binding protein kinase C binding insulin-like growth factor receptor binding protein binding cytoplasm cytosol protein targeting protein domain specific binding receptor tyrosine kinase binding vesicle cellular response to insulin stimulus identical protein binding myelin sheath synapse regulation of neuron differentiation regulation of synaptic plasticity presynapse uc008zzf.1 uc008zzf.2 uc008zzf.3 uc008zzf.4 
ENSMUST00000055820.7 ENSMUSG00000121649 ENSMUST00000055820.7 ENSMUSG00000121649 (from geneSymbol) ENSMUST00000055820.1 ENSMUST00000055820.2 ENSMUST00000055820.3 ENSMUST00000055820.4 ENSMUST00000055820.5 ENSMUST00000055820.6 uc292jdy.1 uc292jdy.2 uc292jdy.1 uc292jdy.2 
ENSMUST00000055833.12 Atf2 ENSMUST00000055833.12 activating transcription factor 2, transcript variant 6 (from RefSeq NM_001284371.1) ATF2_MOUSE ENSMUST00000055833.1 ENSMUST00000055833.10 ENSMUST00000055833.11 ENSMUST00000055833.2 ENSMUST00000055833.3 ENSMUST00000055833.4 ENSMUST00000055833.5 ENSMUST00000055833.6 ENSMUST00000055833.7 ENSMUST00000055833.8 ENSMUST00000055833.9 NM_001284371 P16951 Q64089 Q64090 Q64091 uc289wza.1 uc289wza.2 Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type (By similarity). Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Heterodimerization is essential for its transcriptional activity. Interacts with SMAD3 and SMAD4. Interacts with the HK1/VDAC1 complex. Interacts with NBN, MRE11, XPO1, KAT5 and CUL3 (By similarity). Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity. Nucleus. Cytoplasm Mitochondrion outer membrane Note=Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-34 is required for its nuclear localization and negatively regulates its mitochondrial localization. Colocalizes with the MRN complex in the IR-induced foci (IRIF) (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P16951-1; Sequence=Displayed; Name=2; IsoId=P16951-2; Sequence=VSP_000590; Name=3; IsoId=P16951-3; Sequence=VSP_000589; Phosphorylation of Thr-51 by MAPK14 and MAPK11, and at Thr-53 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4. ATM-mediated phosphorylation at Ser-472 and Ser-480 stimulates its function in DNA damage response. Phosphorylation at Ser-44, Thr-55 and Ser-103 activates its transcriptional activity. Phosphorylation at Thr-51 or Thr-53 enhances acetylation of histones H2B and H4. Belongs to the bZIP family. ATF subfamily. Appears to have histone acetyltransferase (HAT) activity, specifically towards histones H2B and H4 in vitro (By similarity). However, it is not clear if this activity is genuine or caused by contamination with other histone acetyltransferases in the assay. Sequence=AAB21128.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAB21129.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II activating transcription factor binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding outflow tract morphogenesis nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding histone acetyltransferase activity protein binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter response to osmotic stress cellular response to DNA damage stimulus transcription factor binding cAMP response element binding protein binding response to water deprivation positive regulation of gene expression membrane negative regulation of angiogenesis histone acetylation transferase activity protein kinase binding intra-S DNA damage checkpoint positive regulation of transforming growth factor beta2 production cAMP response element binding site of double-strand break positive regulation of neuron apoptotic process sequence-specific DNA binding fat cell differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding protein heterodimerization activity negative regulation of epithelial cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity adipose tissue development amelogenesis positive regulation of mitochondrial membrane permeability involved in apoptotic process uc289wza.1 uc289wza.2 
ENSMUST00000055843.9 Rbm15b ENSMUST00000055843.9 RNA binding motif protein 15B (from RefSeq NM_175402.5) ENSMUST00000055843.1 ENSMUST00000055843.2 ENSMUST00000055843.3 ENSMUST00000055843.4 ENSMUST00000055843.5 ENSMUST00000055843.6 ENSMUST00000055843.7 ENSMUST00000055843.8 NM_175402 Q6PHZ5 Q8C6G2 RB15B_MOUSE uc012gzz.1 uc012gzz.2 uc012gzz.3 RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1. Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. The MAC subcomplex is composed of METTL3 and METTL14. The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B). May interact with NCOR2. Interacts with NXF1, the interaction is required to promote mRNA export. Nucleus, nucleoplasm Nucleus speckle Nucleus envelope Note=Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli. Belongs to the RRM Spen family. Sequence=AAH52180.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; Sequence=BAC35951.1; Type=Erroneous initiation; Evidence=; regulation of alternative mRNA splicing, via spliceosome RNA methylation nucleic acid binding RNA binding protein binding nucleus nuclear envelope nucleoplasm mRNA processing mRNA export from nucleus RNA splicing dosage compensation by inactivation of X chromosome nuclear speck MIS complex negative regulation of transcription, DNA-templated uc012gzz.1 uc012gzz.2 uc012gzz.3 
ENSMUST00000055844.10 Rbpms2 ENSMUST00000055844.10 RNA binding protein with multiple splicing 2 (from RefSeq NM_028030.3) ENSMUST00000055844.1 ENSMUST00000055844.2 ENSMUST00000055844.3 ENSMUST00000055844.4 ENSMUST00000055844.5 ENSMUST00000055844.6 ENSMUST00000055844.7 ENSMUST00000055844.8 ENSMUST00000055844.9 NM_028030 Q8VC52 RBPS2_MOUSE uc009qdt.1 uc009qdt.2 uc009qdt.3 RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (By similarity). Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity). Homodimer. Interacts with EEF2. Cytoplasm nucleic acid binding RNA binding mRNA binding cytoplasm multicellular organism development negative regulation of BMP signaling pathway protein homodimerization activity embryonic digestive tract morphogenesis positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell differentiation uc009qdt.1 uc009qdt.2 uc009qdt.3 
ENSMUST00000055858.14 2410002F23Rik ENSMUST00000055858.14 RIKEN cDNA 2410002F23 gene (from RefSeq NM_025880.4) 2410002F23Rik ENSMUST00000055858.1 ENSMUST00000055858.10 ENSMUST00000055858.11 ENSMUST00000055858.12 ENSMUST00000055858.13 ENSMUST00000055858.2 ENSMUST00000055858.3 ENSMUST00000055858.4 ENSMUST00000055858.5 ENSMUST00000055858.6 ENSMUST00000055858.7 ENSMUST00000055858.8 ENSMUST00000055858.9 NM_025880 Q3TE80 Q3TE80_MOUSE uc009gou.1 uc009gou.2 uc009gou.3 uc009gou.1 uc009gou.2 uc009gou.3 
ENSMUST00000055872.3 Galr2 ENSMUST00000055872.3 galanin receptor 2 (from RefSeq NM_010254.4) ENSMUST00000055872.1 ENSMUST00000055872.2 GALR2_MOUSE Galnr2 NM_010254 O88854 Q14A53 Q9Z2B0 uc007mkr.1 uc007mkr.2 uc007mkr.3 Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity galanin receptor activity plasma membrane integral component of plasma membrane cilium signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane peptide hormone binding neuron projection development neuropeptide binding inositol phosphate metabolic process positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol metabolic process galanin-activated signaling pathway positive regulation of large conductance calcium-activated potassium channel activity uc007mkr.1 uc007mkr.2 uc007mkr.3 
ENSMUST00000055884.8 Htr5b ENSMUST00000055884.8 5-hydroxytryptamine (serotonin) receptor 5B (from RefSeq NM_010483.3) ENSMUST00000055884.1 ENSMUST00000055884.2 ENSMUST00000055884.3 ENSMUST00000055884.4 ENSMUST00000055884.5 ENSMUST00000055884.6 ENSMUST00000055884.7 G3X9C6 G3X9C6_MOUSE Htr5b NM_010483 uc011wqx.1 uc011wqx.2 uc011wqx.3 uc011wqx.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway serotonin receptor signaling pathway drug binding membrane integral component of membrane serotonin binding uc011wqx.1 uc011wqx.2 uc011wqx.3 uc011wqx.4 
ENSMUST00000055892.10 Catsper4 ENSMUST00000055892.10 cation channel, sperm associated 4, transcript variant 1 (from RefSeq NM_177866.4) A2A9K6 CTSR4_MOUSE ENSMUST00000055892.1 ENSMUST00000055892.2 ENSMUST00000055892.3 ENSMUST00000055892.4 ENSMUST00000055892.5 ENSMUST00000055892.6 ENSMUST00000055892.7 ENSMUST00000055892.8 ENSMUST00000055892.9 NM_177866 Q8BVN3 uc008veh.1 uc008veh.2 uc008veh.3 uc008veh.4 Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. In contrast to the human ortholog, not activated by progesterone. Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG2, CATSPERD, CATSPERE, CATSPERZ, C2CD6/CATSPERT, SLCO6C1, TMEM249, TMEM262 and EFCAB9 (PubMed:34225353, PubMed:21224844, PubMed:17227845). HSPA1 may be an additional auxiliary complex member (By similarity). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (PubMed:34225353). The auxiliary CATSPERB, CATSPERG2, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively (PubMed:34225353). SLCO6C1 interacts with CATSPERE and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex (PubMed:34225353). C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane (Probable). Q8BVN3; Q91ZR5: Catsper1; NbExp=2; IntAct=EBI-15619199, EBI-15619083; Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein Note=Specifically located in the principal piece of the sperm tail. Testis-specific. Detected in hte testis during postnatal development at day 15. Restricted to the late-stage germline cells that line the seminiferous tubules. Mice are normal but males are sterile. Male sterility is due to defects in sperm motility unability to fertilize intact eggs. Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. Sequence=CAM21941.1; Type=Erroneous gene model prediction; Evidence=; acrosomal vesicle ion channel activity calcium activated cation channel activity voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity protein binding plasma membrane cilium ion transport sodium ion transport calcium ion transport multicellular organism development spermatogenesis membrane integral component of membrane cell differentiation flagellated sperm motility motile cilium regulation of ion transmembrane transport CatSper complex cell projection sperm capacitation transmembrane transport calcium ion transmembrane transport sperm principal piece uc008veh.1 uc008veh.2 uc008veh.3 uc008veh.4 
ENSMUST00000055915.6 Hdgfl1 ENSMUST00000055915.6 HDGF like 1 (from RefSeq NM_008232.3) ENSMUST00000055915.1 ENSMUST00000055915.2 ENSMUST00000055915.3 ENSMUST00000055915.4 ENSMUST00000055915.5 Hdgfl1 NM_008232 Q2VPR5 Q2VPR5_MOUSE uc007pxa.1 uc007pxa.2 uc007pxa.3 uc007pxa.4 molecular_function cellular_component biological_process uc007pxa.1 uc007pxa.2 uc007pxa.3 uc007pxa.4 
ENSMUST00000055921.14 Npdc1 ENSMUST00000055921.14 Npdc1 (from geneSymbol) A2AJ21 A2AJ21_MOUSE AK146466 ENSMUST00000055921.1 ENSMUST00000055921.10 ENSMUST00000055921.11 ENSMUST00000055921.12 ENSMUST00000055921.13 ENSMUST00000055921.2 ENSMUST00000055921.3 ENSMUST00000055921.4 ENSMUST00000055921.5 ENSMUST00000055921.6 ENSMUST00000055921.7 ENSMUST00000055921.8 ENSMUST00000055921.9 Npdc1 uc289txc.1 uc289txc.2 membrane integral component of membrane uc289txc.1 uc289txc.2 
ENSMUST00000055922.4 Lurap1l ENSMUST00000055922.4 leucine rich adaptor protein 1-like (from RefSeq NM_026821.5) A2AQI1 D4Bwg0951e ENSMUST00000055922.1 ENSMUST00000055922.2 ENSMUST00000055922.3 LUR1L_MOUSE NM_026821 Q8K2P1 Q9D150 uc008tjv.1 uc008tjv.2 uc008tjv.3 Sequence=BAB23088.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling uc008tjv.1 uc008tjv.2 uc008tjv.3 
ENSMUST00000055923.8 Or2d4 ENSMUST00000055923.8 olfactory receptor family 2 subfamily D member 4 (from RefSeq NM_146601.1) ENSMUST00000055923.1 ENSMUST00000055923.2 ENSMUST00000055923.3 ENSMUST00000055923.4 ENSMUST00000055923.5 ENSMUST00000055923.6 ENSMUST00000055923.7 NM_146601 Olfr710 Or2d4 Q9EP55 Q9EP55_MOUSE uc009jan.1 uc009jan.2 uc009jan.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus uc009jan.1 uc009jan.2 uc009jan.3 
ENSMUST00000055931.5 Dusp18 ENSMUST00000055931.5 dual specificity phosphatase 18 (from RefSeq NM_173745.5) DUS18_MOUSE ENSMUST00000055931.1 ENSMUST00000055931.2 ENSMUST00000055931.3 ENSMUST00000055931.4 NM_173745 Q8VE01 uc007htu.1 uc007htu.2 uc007htu.3 Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Cytoplasm Nucleus Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side Note=Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. inactivation of MAPK activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus nucleoplasm cytoplasm mitochondrion mitochondrial inner membrane mitochondrial intermembrane space protein dephosphorylation protein targeting to membrane protein targeting to mitochondrion protein tyrosine/serine/threonine phosphatase activity membrane dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity intrinsic component of mitochondrial inner membrane extrinsic component of mitochondrial inner membrane protein localization to organelle peptidyl-tyrosine dephosphorylation peptidyl-threonine dephosphorylation response to antibiotic uc007htu.1 uc007htu.2 uc007htu.3 
ENSMUST00000055935.11 Pcdhgc5 ENSMUST00000055935.11 protocadherin gamma subfamily C, 5 (from RefSeq NM_033583.3) ENSMUST00000055935.1 ENSMUST00000055935.10 ENSMUST00000055935.2 ENSMUST00000055935.3 ENSMUST00000055935.4 ENSMUST00000055935.5 ENSMUST00000055935.6 ENSMUST00000055935.7 ENSMUST00000055935.8 ENSMUST00000055935.9 NM_033583 Pcdhgc5 Q91XW9 Q91XW9_MOUSE uc008erg.1 uc008erg.2 uc008erg.3 uc008erg.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane metal ion binding synapse organization uc008erg.1 uc008erg.2 uc008erg.3 uc008erg.4 
ENSMUST00000055946.8 Gpr158 ENSMUST00000055946.8 G protein-coupled receptor 158 (from RefSeq NM_001004761.1) B1AWY4 ENSMUST00000055946.1 ENSMUST00000055946.2 ENSMUST00000055946.3 ENSMUST00000055946.4 ENSMUST00000055946.5 ENSMUST00000055946.6 ENSMUST00000055946.7 Gpr158 Kiaa1136 MGLYR_MOUSE NM_001004761 Q8C419 Q8CHB0 uc008inf.1 uc008inf.2 uc008inf.3 uc008inf.4 Metabotropic receptor for glycine that controls synapse formation and function in the brain (PubMed:29419376, PubMed:31749686, PubMed:31311860, PubMed:36996198). Acts as an atypical G-protein coupled receptor that recruits and regulates the RGS7-GNB5 complex instead of activating G proteins (PubMed:22689652, PubMed:25792749, PubMed:31311860, PubMed:30546127). In absence of glycine ligand, promotes the GTPase activator activity of RGS7, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). Glycine-binding changes the conformation of the intracellular surface, inhibiting the GTPase activator activity of the RGS7-GNB5 complex, promoting G protein alpha subunits into their active GTP-bound form and regulating cAMP levels (By similarity). Also able to bind taurine, a compound closely related to glycine, but with a two-fold lower affinity (By similarity). Glycine receptor-dependent regulation of cAMP controls key ion channels, kinases and neurotrophic factors involved in neuronal excitability and synaptic transmission (PubMed:31311860, PubMed:36996198). Plays a pivotal role in regulating mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (PubMed:28851741, PubMed:29419376, PubMed:31749686, PubMed:31311860, PubMed:30546127). Also involved in spatial learning by regulating hippocampal CA1 neuronal excitability (PubMed:31749686). Acts as a synaptic organizer in the hippocampus, required for proper mossy fiber-CA3 neurocircuitry establishment, structure and function: induces presynaptic differentiation in contacting axons via its interaction with GPC4 (PubMed:30290982). In addition to glycine, may also act as a receptor for osteocalcin (Bglap or Bglap2) hormone: osteocalcin-binding initiates a signaling response that prevents neuronal apoptosis in the hippocampus and regulates the synthesis of neurotransmitters (PubMed:28851741, PubMed:30355501). Homodimer (By similarity). Associates with the RGS7-GNB5 complex, promoting its localization to the cell membrane and regulating its GTPase activator activity (PubMed:22689652, PubMed:25792749, PubMed:31311860). Interacts (via VCPWE motifs) with GNAO1 (PubMed:25792749). Interacts with GPC4 (By similarity). Interacts with EGFLAM (PubMed:30282023). Q8C419; P35052: GPC1; Xeno; NbExp=3; IntAct=EBI-776313, EBI-8307554; Q8C419; P78333: GPC5; Xeno; NbExp=2; IntAct=EBI-776313, EBI-2558325; Q8C419; P31431: SDC4; Xeno; NbExp=3; IntAct=EBI-776313, EBI-3913237; Cell membrane ulti-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Presynaptic cell membrane ; Multi-pass membrane protein Nucleus Note=Mainly localizes to the postsynaptic membrane, with a small portion to the presynaptic membrane (PubMed:36979415). Trafficks between the nucleus and the cell membrane; it is unclear how a multi-pass membrane protein can traffick between the nucleus and the cell membrane (By similarity). Highly expressed in brain (PubMed:29419376, PubMed:36979415). Expressed in several brain regions including the cerebral cortex, hippocampus, cerebellum and caudate putamen (PubMed:36979415). Only expressed in neurons, and not in microglia, oligodendrocytes or astrocytes (PubMed:36979415). Expressed in the visual center of the cerebral cortex (PubMed:30855200). Also expressed in the eye, including photoreceptors, ganglion cells and trabecular meshwork (PubMed:30855200). Expression in the dentate gyrus is regulated by RBBP4 (PubMed:30355501). Strongly up-regulated in the prefrontal cortex in response to stress (PubMed:29419376). Down-regulated in the hippocampus in response to hyperglycemia (PubMed:36634900). The Cache-like region shares similarity with the Cache domain, a well-known receptor for amino acids (By similarity). It acts as a ligand-binding module that recognizes and binds glycine and taurine (By similarity). Mice show prominent antidepressant-like phenotype and stress resilience, characterized by attenuated response to stress- induced hyperthermia (PubMed:29419376). Mice also display defects in spatial learning and decreased acquisition of safety learning (PubMed:31749686). Mice show a short-term protection against the intraocular pressure increase that occurred with aging; however this protection is reversed over time (PubMed:30855200). Belongs to the G-protein coupled receptor 3 family. G-protein coupled receptor activity protein binding plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane protein localization to plasma membrane uc008inf.1 uc008inf.2 uc008inf.3 uc008inf.4 
ENSMUST00000055947.10 Samd14 ENSMUST00000055947.10 sterile alpha motif domain containing 14, transcript variant 2 (from RefSeq NM_146025.2) ENSMUST00000055947.1 ENSMUST00000055947.2 ENSMUST00000055947.3 ENSMUST00000055947.4 ENSMUST00000055947.5 ENSMUST00000055947.6 ENSMUST00000055947.7 ENSMUST00000055947.8 ENSMUST00000055947.9 NM_146025 Q5SWB7 Q8BHE2 Q8C8N5 Q8K070 SAM14_MOUSE uc007kzt.1 uc007kzt.2 Sequence=BAC32983.1; Type=Frameshift; Evidence=; Sequence=BAC33903.1; Type=Frameshift; Evidence=; cytoplasm actin filament organization postsynaptic density actin cytoskeleton calcium-mediated signaling dendrite neuron projection development actin filament binding uc007kzt.1 uc007kzt.2 
ENSMUST00000055949.4 Pcdhb18 ENSMUST00000055949.4 protocadherin beta 18 (from RefSeq NM_053143.3) ENSMUST00000055949.1 ENSMUST00000055949.2 ENSMUST00000055949.3 NM_053143 PCDBI_MOUSE Q91Y02 uc008eqd.1 uc008eqd.2 uc008eqd.3 Potential calcium-dependent cell-adhesion protein. Cell membrane ; Single-pass membrane protein molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eqd.1 uc008eqd.2 uc008eqd.3 
ENSMUST00000055964.8 Vmn1r67 ENSMUST00000055964.8 vomeronasal 1 receptor 67 (from RefSeq NM_134229.2) ENSMUST00000055964.1 ENSMUST00000055964.2 ENSMUST00000055964.3 ENSMUST00000055964.4 ENSMUST00000055964.5 ENSMUST00000055964.6 ENSMUST00000055964.7 G5E8C1 G5E8C1_MOUSE NM_134229 Vmn1r67 uc009fde.1 uc009fde.2 uc009fde.3 uc009fde.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009fde.1 uc009fde.2 uc009fde.3 uc009fde.4 
ENSMUST00000055966.13 Gabra3 ENSMUST00000055966.13 gamma-aminobutyric acid type A receptor subunit alpha 3, transcript variant 1 (from RefSeq NM_008067.4) ENSMUST00000055966.1 ENSMUST00000055966.10 ENSMUST00000055966.11 ENSMUST00000055966.12 ENSMUST00000055966.2 ENSMUST00000055966.3 ENSMUST00000055966.4 ENSMUST00000055966.5 ENSMUST00000055966.6 ENSMUST00000055966.7 ENSMUST00000055966.8 ENSMUST00000055966.9 GBRA3_MOUSE Gabra-3 NM_008067 P26049 uc009tkp.1 uc009tkp.2 uc009tkp.3 uc009tkp.4 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1 (PubMed:11528422). Interacts with GPHN (By similarity). Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Modified_positions=342 ; Note=The extent of editing is low at birth but increases with age, reaching close to 100% in the adult brain.; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub- subfamily. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity inhibitory extracellular ligand-gated ion channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction gamma-aminobutyric acid signaling pathway chemical synaptic transmission membrane integral component of membrane GABA-gated chloride ion channel activity cell junction dendrite membrane ion transmembrane transport chloride channel complex regulation of membrane potential neuron projection synapse postsynaptic membrane neurological system process synaptic transmission, GABAergic regulation of postsynaptic membrane potential postsynapse GABA-ergic synapse integral component of postsynaptic specialization membrane chloride transmembrane transport GABA-A receptor complex transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential benzodiazepine receptor activity uc009tkp.1 uc009tkp.2 uc009tkp.3 uc009tkp.4 
ENSMUST00000055984.7 Isg20l2 ENSMUST00000055984.7 interferon stimulated exonuclease gene 20-like 2 (from RefSeq NM_177663.5) A0A0R4J0R3 A0A0R4J0R3_MOUSE ENSMUST00000055984.1 ENSMUST00000055984.2 ENSMUST00000055984.3 ENSMUST00000055984.4 ENSMUST00000055984.5 ENSMUST00000055984.6 Isg20l2 NM_177663 uc008ptj.1 uc008ptj.2 3'-5'-exoribonuclease activity nucleic acid binding RNA phosphodiester bond hydrolysis, exonucleolytic uc008ptj.1 uc008ptj.2 
ENSMUST00000055990.8 Eef1a2 ENSMUST00000055990.8 eukaryotic translation elongation factor 1 alpha 2 (from RefSeq NM_007906.3) EF1A2_MOUSE ENSMUST00000055990.1 ENSMUST00000055990.2 ENSMUST00000055990.3 ENSMUST00000055990.4 ENSMUST00000055990.5 ENSMUST00000055990.6 ENSMUST00000055990.7 Eef1al NM_007906 P27706 P62631 Stn uc008olh.1 uc008olh.2 uc008olh.3 This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Monomer. Nucleus. Found in a wide range of tissues. The statin expression is specific for nonproliferating cells. Its message is most abundant in G0 phase of 3T3 mouse fibroblasts, but becomes significantly reduced in G1 and S1 phases cells. Trimethylated at Lys-165 by EEF1AKMT3. Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs. Trimethylated at the N- terminus and dimethylated at Lys-55 by METTL13. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. nucleotide binding translation elongation factor activity GTPase activity GTP binding nucleus cytoplasm eukaryotic translation elongation factor 1 complex translation translational elongation response to inorganic substance protein kinase binding neuronal cell body positive regulation of apoptotic process myelin sheath synapse response to electrical stimulus positive regulation of lipid kinase activity uc008olh.1 uc008olh.2 uc008olh.3 
ENSMUST00000056006.11 Onecut1 ENSMUST00000056006.11 one cut domain, family member 1 (from RefSeq NM_008262.3) ENSMUST00000056006.1 ENSMUST00000056006.10 ENSMUST00000056006.2 ENSMUST00000056006.3 ENSMUST00000056006.4 ENSMUST00000056006.5 ENSMUST00000056006.6 ENSMUST00000056006.7 ENSMUST00000056006.8 ENSMUST00000056006.9 HNF6_MOUSE Hnf6 Hnf6a NM_008262 O08755 uc009qrh.1 uc009qrh.2 uc009qrh.3 uc009qrh.4 Transcriptional activator. Binds the consensus sequence 5'- DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. Stimulates the expression of Onecut3 in the developing endoderm. Binds DNA as a monomer. Nucleus. Belongs to the CUT homeobox family. RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding liver development regulation of cell-matrix adhesion epithelial cell development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm glucose metabolic process regulation of transcription from RNA polymerase II promoter Notch signaling pathway endoderm development anatomical structure morphogenesis cell differentiation B cell differentiation positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway pancreas development endocrine pancreas development cell fate commitment positive regulation of transcription from RNA polymerase II promoter spleen development cilium assembly uc009qrh.1 uc009qrh.2 uc009qrh.3 uc009qrh.4 
ENSMUST00000056014.3 Ifne ENSMUST00000056014.3 interferon epsilon (from RefSeq NM_177348.2) ENSMUST00000056014.1 ENSMUST00000056014.2 IFNE_MOUSE Ifne1 Ifnt1 NM_177348 Q80ZF2 uc008tod.1 uc008tod.2 Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral, including HSV-2, and bacterial, including Chlamydia muridarum, genital infections. Secreted Expressed at very high levels in uterus and, at much lower levels, in ovary and cervix. Very low levels, if any, in other organs. In the endometrium, expressed in the luminal and glandular epithelial cells (at protein level). Expression varies approximately 30-fold during the estrous cycle, with lowest levels during diestrus and highest at estrus. During pregnancy, uterine expression is dramatically reduced at 1.5 dpc and reaches its lowest levels at 4.5 dpc, coincident with the time of embryo implantation. By estrogens. Contrary to other type I interferons, not induced by known pattern-recognition receptor pathways. Mutant females are substantially more susceptible to (and less able to clear) an ascending infection in the reproductive tract than wild-type animals. Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation defense response to bacterium response to exogenous dsRNA defense response to virus uc008tod.1 uc008tod.2 
ENSMUST00000056023.5 Adam34l ENSMUST00000056023.5 a disintegrin and metallopeptidase domain 34 like (from RefSeq NM_001025240.2) Adam34l Adam36 EG384813 ENSMUST00000056023.1 ENSMUST00000056023.2 ENSMUST00000056023.3 ENSMUST00000056023.4 Gm5346 NM_001025240 Q7M766 Q7M766_MOUSE uc009log.1 uc009log.2 uc009log.3 Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function metalloendopeptidase activity cellular_component proteolysis biological_process metallopeptidase activity membrane integral component of membrane uc009log.1 uc009log.2 uc009log.3 
ENSMUST00000056028.11 Sbk1 ENSMUST00000056028.11 SH3-binding kinase 1, transcript variant 2 (from RefSeq NM_145587.4) ENSMUST00000056028.1 ENSMUST00000056028.10 ENSMUST00000056028.2 ENSMUST00000056028.3 ENSMUST00000056028.4 ENSMUST00000056028.5 ENSMUST00000056028.6 ENSMUST00000056028.7 ENSMUST00000056028.8 ENSMUST00000056028.9 NM_145587 Q8QZX0 SBK1_MOUSE Sbk uc009jqw.1 uc009jqw.2 uc009jqw.3 May be involved in signal-transduction pathways related to the control of brain development. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Cytoplasm Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding cellular_component cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation uc009jqw.1 uc009jqw.2 uc009jqw.3 
ENSMUST00000056032.9 E4f1 ENSMUST00000056032.9 E4F transcription factor 1, transcript variant 6 (from RefSeq NR_188838.1) E4F1_MOUSE ENSMUST00000056032.1 ENSMUST00000056032.2 ENSMUST00000056032.3 ENSMUST00000056032.4 ENSMUST00000056032.5 ENSMUST00000056032.6 ENSMUST00000056032.7 ENSMUST00000056032.8 NR_188838 Q05BH7 Q3UNJ9 Q62065 Q6IR08 Q6PGI1 Q8CCE9 Q9QY56 uc008avy.1 uc008avy.2 uc008avy.3 uc008avy.4 May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin- associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homodimer; binds DNA as a dimer (By similarity). Forms a complex with CDKN2A and TP53. Interacts with HDAC1, HMGA2 and RASSF1 (By similarity). Interactions with TP53, RB1, ANP32A and probably BMI1 and FHL2 regulate E4F1 activity. Q8CCE9; O35381: Anp32a; NbExp=2; IntAct=EBI-7450874, EBI-643140; Nucleus, nucleoplasm Cytoplasm Note=A small fraction is detected in the cytoplasm (By similarity). Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during embryogenesis. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8CCE9-1; Sequence=Displayed; Name=2; IsoId=Q8CCE9-2; Sequence=VSP_032196, VSP_032197; Name=3; IsoId=Q8CCE9-3; Sequence=VSP_032193; Name=4; IsoId=Q8CCE9-4; Sequence=VSP_032194, VSP_032195; Name=5; IsoId=Q8CCE9-5; Sequence=VSP_032192; Ubiquitously expressed. Continuously expressed during embryogenesis. Phosphorylated; phosphorylation is cell cycle-dependent and regulates DNA-binding activity and function. May be sumoylated by UBE2I upon interaction with CDKN2A. Death before 7.5 dpc probably at the peri- implantation stage. Blastocysts display defects in mitotic progression and chromosomal segregation and increased apoptosis. Sequence=AAF22563.1; Type=Frameshift; Evidence=; Sequence=AAH71228.1; Type=Frameshift; Evidence=; Sequence=BAE25748.1; Type=Erroneous initiation; Evidence=; Sequence=CAA54188.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding nucleic acid binding DNA binding protein binding nucleus nucleoplasm cytoplasm spindle DNA replication regulation of transcription, DNA-templated cell cycle regulation of mitotic cell cycle, embryonic regulation of cell cycle process protein ubiquitination transferase activity cAMP response element binding regulation of growth metal ion binding cell division uc008avy.1 uc008avy.2 uc008avy.3 uc008avy.4 
ENSMUST00000056045.5 Fam185a ENSMUST00000056045.5 family with sequence similarity 185, member A, transcript variant 6 (from RefSeq NR_188853.1) ENSMUST00000056045.1 ENSMUST00000056045.2 ENSMUST00000056045.3 ENSMUST00000056045.4 F185A_MOUSE NR_188853 Q7TPD2 Q8C6A4 uc008woo.1 uc008woo.2 uc008woo.3 uc008woo.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TPD2-1; Sequence=Displayed; Name=2; IsoId=Q7TPD2-2; Sequence=VSP_031805, VSP_031806; molecular_function cytosol biological_process uc008woo.1 uc008woo.2 uc008woo.3 uc008woo.4 
ENSMUST00000056051.11 Car7 ENSMUST00000056051.11 carbonic anhydrase 7, transcript variant 1 (from RefSeq NM_053070.3) CAH7_MOUSE Ca7 ENSMUST00000056051.1 ENSMUST00000056051.10 ENSMUST00000056051.2 ENSMUST00000056051.3 ENSMUST00000056051.4 ENSMUST00000056051.5 ENSMUST00000056051.6 ENSMUST00000056051.7 ENSMUST00000056051.8 ENSMUST00000056051.9 NM_053070 Q811X4 Q9ERQ8 uc009nau.1 uc009nau.2 Reversible hydration of carbon dioxide. Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Cytoplasm Belongs to the alpha-carbonic anhydrase family. carbonate dehydratase activity cytoplasm cytosol zinc ion binding lyase activity positive regulation of synaptic transmission, GABAergic positive regulation of cellular pH reduction metal ion binding regulation of chloride transport uc009nau.1 uc009nau.2 
ENSMUST00000056071.13 Ifi209 ENSMUST00000056071.13 interferon activated gene 209 (from RefSeq NM_175026.3) ENSMUST00000056071.1 ENSMUST00000056071.10 ENSMUST00000056071.11 ENSMUST00000056071.12 ENSMUST00000056071.2 ENSMUST00000056071.3 ENSMUST00000056071.4 ENSMUST00000056071.5 ENSMUST00000056071.6 ENSMUST00000056071.7 ENSMUST00000056071.8 ENSMUST00000056071.9 IFIX_MOUSE Ifix NM_175026 Pyhin1 Q3KNA6 Q3KNA7 Q8BLY5 Q8BV49 Q8BVS6 uc007drr.1 uc007drr.2 uc007drr.3 uc007drr.4 Nucleus Belongs to the HIN-200 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding activation of innate immune response double-stranded DNA binding nucleus nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding uc007drr.1 uc007drr.2 uc007drr.3 uc007drr.4 
ENSMUST00000056078.9 Mrps12 ENSMUST00000056078.9 mitochondrial ribosomal protein S12, transcript variant 2 (from RefSeq NM_011885.5) ENSMUST00000056078.1 ENSMUST00000056078.2 ENSMUST00000056078.3 ENSMUST00000056078.4 ENSMUST00000056078.5 ENSMUST00000056078.6 ENSMUST00000056078.7 ENSMUST00000056078.8 NM_011885 O35680 RT12_MOUSE Rpms12 uc009fzo.1 uc009fzo.2 uc009fzo.3 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uS12 family. structural constituent of ribosome mitochondrion mitochondrial small ribosomal subunit ribosome translation small ribosomal subunit mitochondrial translation uc009fzo.1 uc009fzo.2 uc009fzo.3 
ENSMUST00000056085.6 Csl ENSMUST00000056085.6 citrate synthase like (from RefSeq NM_027945.4) Csl ENSMUST00000056085.1 ENSMUST00000056085.2 ENSMUST00000056085.3 ENSMUST00000056085.4 ENSMUST00000056085.5 NM_027945 Q80X68 Q80X68_MOUSE uc007gxo.1 uc007gxo.2 uc007gxo.3 Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2. Homodimer. Mitochondrion matrix Belongs to the citrate synthase family. citrate (Si)-synthase activity mitochondrion mitochondrial matrix carbohydrate metabolic process tricarboxylic acid cycle citrate metabolic process transferase activity transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer uc007gxo.1 uc007gxo.2 uc007gxo.3 
ENSMUST00000056086.5 4930442H23Rik ENSMUST00000056086.5 4930442H23Rik (from geneSymbol) AK015362 ENSMUST00000056086.1 ENSMUST00000056086.2 ENSMUST00000056086.3 ENSMUST00000056086.4 uc287tgc.1 uc287tgc.2 uc287tgc.1 uc287tgc.2 
ENSMUST00000056087.4 Tprg1 ENSMUST00000056087.4 transformation related protein 63 regulated 1 (from RefSeq NM_175165.3) ENSMUST00000056087.1 ENSMUST00000056087.2 ENSMUST00000056087.3 Fam79b NM_175165 Q8CB49 TPRG1_MOUSE Tprg Tprg1 uc007yum.1 uc007yum.2 Cytoplasm Highly expressed in skin. Also detected at low levels in tongue and esophagus. Detected from embryonic stage 15.5 onwards. At stage 17.5 dpc, detected in epidermis and developing hair follicles. Expression levels in skin increase 4 days after birth and are mainly restricted to differentiated layers of the epidermis. Belongs to the TPRG1 family. molecular_function cytoplasm biological_process uc007yum.1 uc007yum.2 
ENSMUST00000056089.8 Tmem37 ENSMUST00000056089.8 transmembrane protein 37 (from RefSeq NM_019432.3) CCGL_MOUSE Cacng5 ENSMUST00000056089.1 ENSMUST00000056089.2 ENSMUST00000056089.3 ENSMUST00000056089.4 ENSMUST00000056089.5 ENSMUST00000056089.6 ENSMUST00000056089.7 NM_019432 Pr Pr1 Q543K0 Q9JJV3 uc007cjd.1 uc007cjd.2 uc007cjd.3 Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). Modulates calcium current when coexpressed with CACNA1G. The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Membrane ; Multi-pass membrane protein Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. voltage-gated ion channel activity calcium channel activity ion transport calcium ion transport membrane integral component of membrane regulation of ion transmembrane transport calcium ion transmembrane transport uc007cjd.1 uc007cjd.2 uc007cjd.3 
ENSMUST00000056096.15 Zfp697 ENSMUST00000056096.15 zinc finger protein 697, transcript variant 1 (from RefSeq NM_172863.5) ENSMUST00000056096.1 ENSMUST00000056096.10 ENSMUST00000056096.11 ENSMUST00000056096.12 ENSMUST00000056096.13 ENSMUST00000056096.14 ENSMUST00000056096.2 ENSMUST00000056096.3 ENSMUST00000056096.4 ENSMUST00000056096.5 ENSMUST00000056096.6 ENSMUST00000056096.7 ENSMUST00000056096.8 ENSMUST00000056096.9 G5E8C0 G5E8C0_MOUSE NM_172863 Zfp697 uc012cui.1 uc012cui.2 uc012cui.3 nucleic acid binding uc012cui.1 uc012cui.2 uc012cui.3 
ENSMUST00000056097.11 Themis ENSMUST00000056097.11 thymocyte selection associated, transcript variant 1 (from RefSeq NM_178666.6) ENSMUST00000056097.1 ENSMUST00000056097.10 ENSMUST00000056097.2 ENSMUST00000056097.3 ENSMUST00000056097.4 ENSMUST00000056097.5 ENSMUST00000056097.6 ENSMUST00000056097.7 ENSMUST00000056097.8 ENSMUST00000056097.9 NM_178666 Q059Y0 Q3TEM0 Q3UU76 Q8BGP0 Q8BGW0 Q8C9S6 THMS1_MOUSE uc007esp.1 uc007esp.2 uc007esp.3 uc007esp.4 This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. Interacts with PLCG1, ITK, GRB2, and LAT. Q8BGW0-1; Q60631-1: Grb2; NbExp=3; IntAct=EBI-15806957, EBI-15532571; Cytoplasm cleus Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8BGW0-1; Sequence=Displayed; Name=2; IsoId=Q8BGW0-2; Sequence=VSP_020922; Name=3; IsoId=Q8BGW0-3; Sequence=VSP_020923; Name=4; IsoId=Q8BGW0-4; Sequence=VSP_020919, VSP_020924; Name=5; IsoId=Q8BGW0-5; Sequence=VSP_020920, VSP_020921; Expressed in the thymus and to a lesser extent in the spleen but not detectable in non-lymphoid tissues. Highly expressed in thymocytes between the pre-T-cell antigen receptor (pre-TCR) and positive-selection checkpoints and expressed at low level in mature T- cells (at protein level). Down-regulated by stimulation through the alpha-beta TCR. Phosphorylated on Tyr residues quickly after TCR stimulation. Mice are viable, are born at the expected Mendelian frequency and present no gross abnormalities. They however display a blockade in late T-cell development with defects in thymocyte selection. The number of transitional CD4(+)CD8(int) thymocytes as well as CD4(+) or CD8(+) single-positive thymocytes is lower. Thymocytes show defective positive selection, resulting in fewer mature thymocytes. Negative selection is also impaired. A greater percentage of T-cells have CD4(+)CD25(+)Foxp3(+) regulatory and CD62L(lo)CD44(hi) memory phenotypes compared to wild-type T-cells. Belongs to the themis family. adaptive immune response immune system process protein binding nucleus cytoplasm cell-cell junction multicellular organism development COP9 signalosome positive T cell selection negative T cell selection T cell receptor signaling pathway uc007esp.1 uc007esp.2 uc007esp.3 uc007esp.4 
ENSMUST00000056102.9 Dscam ENSMUST00000056102.9 DS cell adhesion molecule (from RefSeq NM_031174.4) DSCAM_MOUSE ENSMUST00000056102.1 ENSMUST00000056102.2 ENSMUST00000056102.3 ENSMUST00000056102.4 ENSMUST00000056102.5 ENSMUST00000056102.6 ENSMUST00000056102.7 ENSMUST00000056102.8 NM_031174 Q9ERC8 uc008add.1 uc008add.2 uc008add.3 uc008add.4 Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:18216855, PubMed:19196994, PubMed:19945391). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC (PubMed:18585357). Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (PubMed:22685302). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). Homodimer; mediates homophilic interactions to promote cell adhesion (By similarity). Interacts with DCC; the interaction is abolished in response to NTN1 (PubMed:18585357). Interacts (via extracellular domain) with NTN1 (PubMed:18585357). Interacts (via extracellular domain) with UNC5C (via Ig-like C2-type domain) (PubMed:22685302). Interacts with PTK2 (PubMed:22685302). Interacts with FYN (PubMed:22685302). Q9ERC8; P70211: Dcc; NbExp=4; IntAct=EBI-1798601, EBI-1798863; Q9ERC8; Q61214: Dyrk1a; NbExp=2; IntAct=EBI-1798601, EBI-80344; Q9ERC8; Q63155: Dcc; Xeno; NbExp=4; IntAct=EBI-1798601, EBI-1798965; Q9ERC8; Q90922: NTN1; Xeno; NbExp=7; IntAct=EBI-1798601, EBI-1798593; Cell membrane ; Single-pass type I membrane protein Cell projection, axon Synapse Cell projection, dendrite Cell projection, growth cone Note=Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. Expressed in cortical and cerebellar neurons, in cells of the external and internal granular layer and of the Purkinje cell layer (at protein level) (PubMed:22685302). In the retina, expressed in dopaminergic and Nos1-positive amacrine cells and most retinal ganglion cells (at protein level). Expressed in the brain with highest levels in the cortex, olfactory bulb, hippocampus, thalamus, cerebellum and spinal cord. Expressed in the retinal ganglion layer (RGL). Expressed in embryo at 11 dpc. Expressed in the spinal cord, including the motor columns, motor axons, dorsal root ganglions, commissural axons and ventral funiculus at 11.5 dpc (at protein level). Detected at 15 dpc in the cortex and cerebellum and at postnatal day 2 in the cerebellum (at protein level) (PubMed:22685302). Expressed in the retinal ganglion layer (RGL) at 12.5, 14.5 and 17 dpc. Expressed in hindbrain (cerebellar plate neurons), midbrain and forebrain at 10 dpc. Expressed in follicles of vibrissae and nasal processes at 12 dpc. Expressed in eyes at 14 dpc. Expressed in spinal cord, heart, liver, forelimb and hindlimb, buds at 14 dpc onwards. Ig-like C2-type domains 7 to 9 are sufficient for interaction with NTN1 and commissural axon outgrowth. The transmembrane domain is necessary for interaction with DCC. Phosphorylated at tyrosine residues (PubMed:22685302). Phosphorylation is enhanced by NTN1 (PubMed:22685302). The ganglion cell layer and developing inner plexiform layer in the retina are disorganised at postnatal day 4 (P4). This desorganisation persisted into adulthood in amacrine and ganglions cells. Amacrine and ganglion cell populations show fasciculated dendrites that self-crossed and their cell bodies are randomly distributed or pulled into clumps. Has been reported to enhance netrin-induced phosphorylation of PAK1 and FYN; and the interaction between DSCAM, PAK1 and RAC1 has been described. This article has been withdrawn by the authors. protein binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules negative regulation of cell adhesion nervous system development axon guidance synapse assembly locomotory behavior retina layer formation membrane integral component of membrane cell junction axon dendrite growth cone netrin-activated signaling pathway positive regulation of phosphorylation cell projection neuronal cell body synapse dendrite morphogenesis positive regulation of axon extension involved in axon guidance post-embryonic retina morphogenesis in camera-type eye camera-type eye photoreceptor cell differentiation dendrite self-avoidance protein binding involved in cell-cell adhesion protein tyrosine kinase binding netrin receptor binding uc008add.1 uc008add.2 uc008add.3 uc008add.4 
ENSMUST00000056108.12 Ankrd16 ENSMUST00000056108.12 ankyrin repeat domain 16, transcript variant 3 (from RefSeq NR_156440.1) A2AS55 ANR16_MOUSE Ankrd16 ENSMUST00000056108.1 ENSMUST00000056108.10 ENSMUST00000056108.11 ENSMUST00000056108.2 ENSMUST00000056108.3 ENSMUST00000056108.4 ENSMUST00000056108.5 ENSMUST00000056108.6 ENSMUST00000056108.7 ENSMUST00000056108.8 ENSMUST00000056108.9 NR_156440 Q8BH84 uc012bqv.1 uc012bqv.2 uc012bqv.3 uc012bqv.4 Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity (PubMed:29769718). Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides (PubMed:29769718). Interacts with AARS; the interaction is direct. A2AS55-1; Q8BGQ7: Aars1; NbExp=6; IntAct=EBI-20710644, EBI-11566807; Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AS55-1; Sequence=Displayed; Name=2; IsoId=A2AS55-2; Sequence=VSP_031593, VSP_031594; Widely expressed in brain (at protein level). Side chains of Lys-102, Lys-135 and Lys-165 capture Ser that is misactivated by AARS/AlaRS. No visible phenotype (PubMed:29769718). Loss of Ankrd16 in mice with a 'sticky' phenotype (mice homozygous for the variant 'Glu-734' in Aars/AlaRS) results in early embryonic lethality (PubMed:29769718). Conditional deletion in postnatal Purkinje cells in mice with a 'sticky' phenotype exacerbates the 'sticky' phenotype and causes widespread protein aggregation and neuron loss (PubMed:29769718). molecular_function nucleus cytoplasm tRNA modification uc012bqv.1 uc012bqv.2 uc012bqv.3 uc012bqv.4 
ENSMUST00000056110.15 Dlk1 ENSMUST00000056110.15 delta like non-canonical Notch ligand 1, transcript variant 5 (from RefSeq NR_033813.1) Dlk1 ENSMUST00000056110.1 ENSMUST00000056110.10 ENSMUST00000056110.11 ENSMUST00000056110.12 ENSMUST00000056110.13 ENSMUST00000056110.14 ENSMUST00000056110.2 ENSMUST00000056110.3 ENSMUST00000056110.4 ENSMUST00000056110.5 ENSMUST00000056110.6 ENSMUST00000056110.7 ENSMUST00000056110.8 ENSMUST00000056110.9 NR_033813 Q925U3 Q925U3_MOUSE dlk uc007pam.1 uc007pam.2 uc007pam.3 uc007pam.4 Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding extracellular space membrane integral component of membrane cell differentiation negative regulation of Notch signaling pathway uc007pam.1 uc007pam.2 uc007pam.3 uc007pam.4 
ENSMUST00000056113.5 Acer1 ENSMUST00000056113.5 alkaline ceramidase 1 (from RefSeq NM_175731.4) A1L3S2 ACER1_MOUSE Acer1 Asah3 ENSMUST00000056113.1 ENSMUST00000056113.2 ENSMUST00000056113.3 ENSMUST00000056113.4 NM_175731 Q8R4X1 uc008ddl.1 uc008ddl.2 Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:12783875). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:12783875). Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide (PubMed:12783875). May also hydrolyze dihydroceramides to produce dihydrosphingosine (By similarity). ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:27126290, PubMed:29056331). Reaction=an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine; Xref=Rhea:RHEA:20856, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868, ChEBI:CHEBI:52639, ChEBI:CHEBI:57756; EC=3.5.1.23; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20857; Evidence=; Reaction=H2O + N-tetracosanoyl-sphing-4-enine = sphing-4-enine + tetracosanoate; Xref=Rhea:RHEA:41283, ChEBI:CHEBI:15377, ChEBI:CHEBI:31014, ChEBI:CHEBI:57756, ChEBI:CHEBI:72965; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41284; Evidence=; Reaction=an N-acylsphinganine + H2O = a fatty acid + sphinganine; Xref=Rhea:RHEA:33551, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868, ChEBI:CHEBI:31488, ChEBI:CHEBI:57817; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33552; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-sphing-4-enine = (9Z)-octadecenoate + sphing-4-enine; Xref=Rhea:RHEA:41299, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57756, ChEBI:CHEBI:77996; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41300; Evidence=; Reaction=H2O + N-(15Z-tetracosenoyl)-sphing-4-enine = (15Z)- tetracosenoate + sphing-4-enine; Xref=Rhea:RHEA:41267, ChEBI:CHEBI:15377, ChEBI:CHEBI:32392, ChEBI:CHEBI:57756, ChEBI:CHEBI:74450; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41268; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Inhibited by sphingosine (PubMed:12783875). Inhibited by Mn(2+), Zn(2+), and Cu(2+) in a dose-dependent manner (PubMed:12783875). Slightly activated by Ca(2+) in a dose-dependent manner (PubMed:12783875). pH dependence: Optimum pH is 8.0. ; Lipid metabolism; sphingolipid metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Highly expressed in skin. Weakly or not expressed in other tissues (PubMed:12783875). Expressed by granular layer of interfollicular epidermis, sebaceous glands and infundibulum (PubMed:29056331). Homozygous knockout mice are viable and fertile, with a normal lifespan but display several postnatal skin phenotypes (PubMed:27126290, PubMed:29056331). It includes an increase in total ceramide levels in the dorsal skin, tail epidermis and dermis (PubMed:27126290, PubMed:29056331). This is associated with hair shafts and sebaceous glands abnormalities, cyclic alopecia, a progressive loss of hair follicle stem cells, hyperproliferation, inflammation and abnormal differentiation of the epidermis and results in increased transepidermal water loss and reduction of fat content during aging (PubMed:27126290, PubMed:29056331). Belongs to the alkaline ceramidase family. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process sphingolipid metabolic process ceramide metabolic process epidermis development response to alkaline pH membrane integral component of membrane hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ceramidase activity regulation of lipid metabolic process sphingolipid biosynthetic process cell differentiation keratinocyte differentiation regulation of water loss via skin sphingosine biosynthetic process ceramide catabolic process metal ion binding sebaceous gland development cellular response to calcium ion dihydroceramidase activity uc008ddl.1 uc008ddl.2 
ENSMUST00000056117.10 Itga2 ENSMUST00000056117.10 integrin alpha 2 (from RefSeq NM_008396.4) ENSMUST00000056117.1 ENSMUST00000056117.2 ENSMUST00000056117.3 ENSMUST00000056117.4 ENSMUST00000056117.5 ENSMUST00000056117.6 ENSMUST00000056117.7 ENSMUST00000056117.8 ENSMUST00000056117.9 ITA2_MOUSE NM_008396 Q62163 Q62469 Q6P1C7 uc007rxw.1 uc007rxw.2 uc007rxw.3 Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E- cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis. Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Membrane; Single-pass type I membrane protein. The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. Belongs to the integrin alpha chain family. beta-amyloid binding response to hypoxia positive regulation of leukocyte migration integrin binding collagen binding nucleus plasma membrane focal adhesion substrate-dependent cell migration hypotonic response cell adhesion cell-matrix adhesion integrin-mediated signaling pathway female pregnancy cell proliferation integrin complex external side of plasma membrane cell surface positive regulation of epithelial cell migration positive regulation of alkaline phosphatase activity response to organic cyclic compound response to amine response to muscle activity positive regulation of smooth muscle cell migration membrane integral component of membrane axon mammary gland development positive regulation of cell projection organization cell-substrate adhesion positive regulation of collagen biosynthetic process positive regulation of collagen binding response to L-ascorbic acid cell adhesion mediated by integrin integrin alpha2-beta1 complex collagen receptor activity collagen-activated signaling pathway wound healing response to drug cell projection laminin binding positive regulation of DNA binding skin morphogenesis axon terminus macromolecular complex binding basal part of cell establishment of protein localization positive regulation of translation positive regulation of cell adhesion positive regulation of smooth muscle contraction metal ion binding protein heterodimerization activity focal adhesion assembly mesodermal cell differentiation perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response positive regulation of positive chemotaxis detection of mechanical stimulus involved in sensory perception of pain positive regulation of transmission of nerve impulse positive regulation of phagocytosis, engulfment hepatocyte differentiation response to parathyroid hormone cellular response to mechanical stimulus cellular response to estradiol stimulus cellular response to organic cyclic compound collagen binding involved in cell-matrix adhesion uc007rxw.1 uc007rxw.2 uc007rxw.3 
ENSMUST00000056118.4 Krtap7-1 ENSMUST00000056118.4 keratin associated protein 7-1 (from RefSeq NM_027771.1) ENSMUST00000056118.1 ENSMUST00000056118.2 ENSMUST00000056118.3 KRA71_MOUSE Kap7.1 Krtap7.1 NM_027771 Q9D3I6 uc012aib.1 uc012aib.2 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the KRTAP type 7 family. molecular_function cellular_component intermediate filament biological_process uc012aib.1 uc012aib.2 
ENSMUST00000056129.9 Npas4 ENSMUST00000056129.9 neuronal PAS domain protein 4 (from RefSeq NM_153553.5) ENSMUST00000056129.1 ENSMUST00000056129.2 ENSMUST00000056129.3 ENSMUST00000056129.4 ENSMUST00000056129.5 ENSMUST00000056129.6 ENSMUST00000056129.7 ENSMUST00000056129.8 NM_153553 NPAS4_MOUSE Npas4 Nxf Q3V3U3 Q8BGD7 uc008gbu.1 uc008gbu.2 uc008gbu.3 uc008gbu.4 Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus (PubMed:18815592, PubMed:22194569, PubMed:23029555, PubMed:24201284, PubMed:24855953). Plays a key role in the structural and functional plasticity of neurons (PubMed:23172225). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (PubMed:24201284, PubMed:24855953). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (PubMed:18815592, PubMed:22194569, PubMed:24201284). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (PubMed:24855953). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (PubMed:18815592, PubMed:22194569, PubMed:23029555, PubMed:24201284, PubMed:27238022). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory- experience-dependent manner by regulating expression of MDM2 (PubMed:25088421). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734, PubMed:15363889, PubMed:19284974). Can activate the CME (CNS midline enhancer) element (PubMed:14701734, PubMed:15363889). Efficient DNA binding requires dimerization with another bHLH protein (PubMed:14701734, PubMed:15363889, PubMed:19284974). Heterodimer; forms a heterodimer with ARNT, ARNT2 or BMAL1 (PubMed:14701734, PubMed:15363889, PubMed:19284974). Nucleus Mainly expressed in brain (PubMed:14701734, PubMed:15363889). Expressed in the limbic system and olfactory bulb (PubMed:15363889, PubMed:25088421). Specifically expressed in CA1 and CA3 region of the hippocampus after contextual learning (at protein level) (PubMed:22194569, PubMed:23029555). Also expressed in pancreatic beta cells (PubMed:26663079). Induced upon calcium influx (PubMed:26663079). Expression is regulated by neuronal activity (at protein level) (PubMed:18815592, PubMed:22194569, PubMed:24201284, PubMed:24855953). Induced in CA3 region of the hippocampus after contextual learning (PubMed:22194569). Induced following sensory input in newborn olfactory bulb interneurons (PubMed:25088421). Induced in the medial prefrontal cortex cells of the brain following experiences with positive valence (PubMed:27238022). Induced in pancreatic beta cells in response to calcium influx (PubMed:26663079). Down-regulated by REST (PubMed:24291638). Transcripts are regulated by a subset of miRNAs, such as miR-203, miR- 224 and miR-744, that bind to its 3'-UTR region and down-regulate its expression (PubMed:24291638, PubMed:27189618). Ubiquitinated, leading to degradation by the proteosome. Mice appear anxious and hyperactive, are prone to seizures and have a shortened lifespan compared with their wild-type littermates (PubMed:18815592, PubMed:19001414, PubMed:23029555, PubMed:25549857). Mice show learning and memory deficits: while having intact memories 5 minutes after training, memory is significantly reduced one hour or 24 hours following training, suggesting that both short-term memory and long-term memory are impaired (PubMed:22194569). Mice show social and cognitive defects: they are hyperactive in a novel environment, spend less time exploring, show higher social dominance than their wild-type littermates and display pre-pulse inhibition, working memory, long-term memory and cognitive flexibility deficits (PubMed:23029555). When exposed to an enriched environment, a significantly less frequent and slightly smaller amplitude inhibitory postsynaptic current is observed (PubMed:24201284). Mice show a reduction in the dendritic spine density in olfactory bulb granule cells, leading to impaired odor discrimination learning (PubMed:25088421). Mice also show increased vulnerability to juvenile stress: mice exposed to chronic mild stress during adolescence, but not during adulthood, develop prefrontal cortex-dependent cognitive deficits in adulthood (PubMed:25911220). Sequence=BAE20480.1; Type=Frameshift; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II regulatory region DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein binding nucleus transcription factor complex regulation of transcription from RNA polymerase II promoter nervous system development learning short-term memory long-term memory cell differentiation regulation of synaptic transmission, GABAergic social behavior positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity regulation of synaptic plasticity excitatory postsynaptic potential inhibitory postsynaptic potential cellular response to corticosterone stimulus postsynapse inhibitory synapse assembly uc008gbu.1 uc008gbu.2 uc008gbu.3 uc008gbu.4 
ENSMUST00000056130.8 Gpr150 ENSMUST00000056130.8 G protein-coupled receptor 150 (from RefSeq NM_175495.2) ENSMUST00000056130.1 ENSMUST00000056130.2 ENSMUST00000056130.3 ENSMUST00000056130.4 ENSMUST00000056130.5 ENSMUST00000056130.6 ENSMUST00000056130.7 GP150_MOUSE NM_175495 Pgr11 Q147V7 Q80UD4 Q8BL07 uc007rgg.1 uc007rgg.2 Orphan receptor. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane cellular response to hormone stimulus uc007rgg.1 uc007rgg.2 
ENSMUST00000056136.4 Kcnj10 ENSMUST00000056136.4 potassium inwardly-rectifying channel, subfamily J, member 10 (from RefSeq NM_001039484.1) ENSMUST00000056136.1 ENSMUST00000056136.2 ENSMUST00000056136.3 KCJ10_MOUSE NM_001039484 Q9JM63 uc007dqj.1 uc007dqj.2 May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (By similarity). Heterodimer with Kir5.1/KCNJ16; this interaction is required for KCNJ16 localization to the basolateral membrane in kidney cells. Interacts with MAGI1, alone and possibly as a heterodimer with KCNJ16; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney cells (By similarity). Interacts with PATJ (PubMed:9647694). Membrane ; Multi- pass membrane protein Basolateral cell membrane Note=In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16. Widely expressed in adult brain, including in the neocortex, the stratum pyrimadale of the hippocampus and the piriform cortex. Expressed by cultured astrocytes and also by cocultured cortical neurons (at protein level). Expressed in the distal segment of the nephron (PubMed:33811157). Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily. nucleotide binding receptor binding inward rectifier potassium channel activity voltage-gated ion channel activity potassium channel activity protein binding ATP binding plasma membrane integral component of plasma membrane microvillus ion transport potassium ion transport visual perception adult walking behavior oligodendrocyte development membrane integral component of membrane basolateral plasma membrane apical plasma membrane central nervous system myelination regulation of ion transmembrane transport regulation of membrane potential identical protein binding regulation of long-term neuronal synaptic plasticity protein homotetramerization regulation of sensory perception of pain glutamate reuptake L-glutamate import potassium ion homeostasis regulation of resting membrane potential membrane hyperpolarization potassium ion transmembrane transport astrocyte projection presynapse potassium ion import across plasma membrane uc007dqj.1 uc007dqj.2 
ENSMUST00000056145.3 Gm5546 ENSMUST00000056145.3 Gm5546 (from geneSymbol) AK044520 ENSMUST00000056145.1 ENSMUST00000056145.2 uc290iim.1 uc290iim.2 uc290iim.1 uc290iim.2 
ENSMUST00000056146.2 1810024B03Rik ENSMUST00000056146.2 RIKEN cDNA 1810024B03 gene (from RefSeq NM_198630.2) 1810024B03Rik ENSMUST00000056146.1 NM_198630 Q8BWE1 Q8BWE1_MOUSE uc008mex.1 uc008mex.2 uc008mex.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Cytoplasm protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation intracellular signal transduction uc008mex.1 uc008mex.2 uc008mex.3 
ENSMUST00000056147.14 Zfp119b ENSMUST00000056147.14 zinc finger protein 119b, transcript variant 1 (from RefSeq NM_146249.4) BC031441 ENSMUST00000056147.1 ENSMUST00000056147.10 ENSMUST00000056147.11 ENSMUST00000056147.12 ENSMUST00000056147.13 ENSMUST00000056147.2 ENSMUST00000056147.3 ENSMUST00000056147.4 ENSMUST00000056147.5 ENSMUST00000056147.6 ENSMUST00000056147.7 ENSMUST00000056147.8 ENSMUST00000056147.9 NM_146249 Q8K0G9 Q8K0G9_MOUSE Zfp119b uc008dah.1 uc008dah.2 uc008dah.3 uc008dah.4 molecular_function nucleic acid binding nucleus regulation of transcription, DNA-templated metal ion binding uc008dah.1 uc008dah.2 uc008dah.3 uc008dah.4 
ENSMUST00000056149.15 Abhd12 ENSMUST00000056149.15 abhydrolase domain containing 12, transcript variant 1 (from RefSeq NM_024465.3) A2ANB4 ABD12_MOUSE Abhd12 ENSMUST00000056149.1 ENSMUST00000056149.10 ENSMUST00000056149.11 ENSMUST00000056149.12 ENSMUST00000056149.13 ENSMUST00000056149.14 ENSMUST00000056149.2 ENSMUST00000056149.3 ENSMUST00000056149.4 ENSMUST00000056149.5 ENSMUST00000056149.6 ENSMUST00000056149.7 ENSMUST00000056149.8 ENSMUST00000056149.9 NM_024465 Q99LR1 Q99M06 uc008muo.1 uc008muo.2 uc008muo.3 uc008muo.4 Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:23297193, PubMed:25580854, PubMed:30420694). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (PubMed:23297193). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283). Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:18096503). Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167). Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine; Xref=Rhea:RHEA:40499, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:64765, ChEBI:CHEBI:74617; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40500; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn- glycerol); Xref=Rhea:RHEA:44584, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:64717, ChEBI:CHEBI:72828; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44585; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo- inositol; Xref=Rhea:RHEA:44588, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:58444, ChEBI:CHEBI:78762; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44589; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:40895, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74971, ChEBI:CHEBI:143890; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40896; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z- octadecenoyl)-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41091, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:75757, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41092; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38491, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:73990; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38492; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O = H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine; Xref=Rhea:RHEA:44552, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64765, ChEBI:CHEBI:75020; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44553; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26133; Evidence=; Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.; EC=3.1.1.23; Evidence=; Reaction=1-decanoylglycerol + H2O = decanoate + glycerol + H(+); Xref=Rhea:RHEA:44320, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:27689, ChEBI:CHEBI:75547; Evidence=; Reaction=1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+); Xref=Rhea:RHEA:44316, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:18262, ChEBI:CHEBI:75539; Evidence=; Reaction=1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate; Xref=Rhea:RHEA:44312, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30807, ChEBI:CHEBI:75562; Evidence=; Reaction=2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:39963, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:75455; Evidence=; Reaction=1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38488; Evidence=; Reaction=2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)- octadecadienoate + glycerol + H(+); Xref=Rhea:RHEA:44732, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30245, ChEBI:CHEBI:75457; Evidence=; Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:44728, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:75612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44729; Evidence=; Reaction=1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)- octadecadienoate + glycerol + H(+); Xref=Rhea:RHEA:48428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30245, ChEBI:CHEBI:75568; Evidence=; Reaction=1-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:39959, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:69081; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39960; Evidence=; Reaction=1-octadecanoylglycerol + H2O = glycerol + H(+) + octadecanoate; Xref=Rhea:RHEA:38363, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:25629, ChEBI:CHEBI:75555; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38364; Evidence=; Reaction=1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3- phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+); Xref=Rhea:RHEA:59364, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:84467, ChEBI:CHEBI:85195, ChEBI:CHEBI:143087; Evidence=; Reaction=1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3- phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:59368, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:84467, ChEBI:CHEBI:143088, ChEBI:CHEBI:143089; Evidence=; Reaction=1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3- phospho-L-serine + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:59372, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:75020, ChEBI:CHEBI:143089, ChEBI:CHEBI:143094; Evidence=; Selectively inhibited by DO264 (N-3-pyridyl-N'-(1- [3-chloro-4-{2-chloro-4-(trifluoromethoxy)phenoxy}pyridine-2- yl]piperidin-4-yl)thiourea). Endoplasmic reticulum membrane ; Single-pass membrane protein Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99LR1-1; Sequence=Displayed; Name=2; IsoId=Q99LR1-2; Sequence=VSP_057493; Glycosylated. Mice are viable and were born at the expected Mendelian frequency (PubMed:23297193). Young mice (less than 6 months old) are mostly normal in their behavior; however, as these animals age, they develop an array of phenotypes, including defective auditory and motor behavior, with concomitant cellular pathology indicative of a neuroinflammatory response (PubMed:23297193). Mice show heightened immunological responses (PubMed:30420694). Metabolomic characterization of brain tissue show striking elevations in a series of lysophosphatidylserine (LPS) lipids that occur before the onset of neuroinflammatory and behavioral defects (PubMed:23297193). Brain tissues accumulate oxidized phosphatidylserine lipids in response to severe inflammatory stress (PubMed:30643283). Belongs to the serine esterase family. Sequence=AAH02138.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein depalmitoylation phospholipase activity lysophospholipase activity cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phosphatidylserine catabolic process adult walking behavior palmitoyl-(protein) hydrolase activity phospholipid catabolic process response to auditory stimulus membrane integral component of membrane hydrolase activity AMPA glutamate receptor complex dendrite cytoplasm acylglycerol catabolic process glycerophospholipid catabolic process acylglycerol lipase activity regulation of inflammatory response monoacylglycerol catabolic process uc008muo.1 uc008muo.2 uc008muo.3 uc008muo.4 
ENSMUST00000056153.8 Fads6 ENSMUST00000056153.8 fatty acid desaturase domain family, member 6 (from RefSeq NM_178035.5) ENSMUST00000056153.1 ENSMUST00000056153.2 ENSMUST00000056153.3 ENSMUST00000056153.4 ENSMUST00000056153.5 ENSMUST00000056153.6 ENSMUST00000056153.7 FADS6_MOUSE NM_178035 Q80UG1 Q80YA0 Q810B5 uc007mgz.1 uc007mgz.2 uc007mgz.3 uc007mgz.4 Lipid metabolism; fatty acid metabolism. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80UG1-1; Sequence=Displayed; Name=2; IsoId=Q80UG1-2; Sequence=VSP_034321; Belongs to the fatty acid desaturase type 1 family. molecular_function cellular_component lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process biological_process membrane integral component of membrane oxidoreductase activity oxidation-reduction process uc007mgz.1 uc007mgz.2 uc007mgz.3 uc007mgz.4 
ENSMUST00000056157.14 Mlkl ENSMUST00000056157.14 mixed lineage kinase domain-like, transcript variant 1 (from RefSeq NM_001310613.1) ENSMUST00000056157.1 ENSMUST00000056157.10 ENSMUST00000056157.11 ENSMUST00000056157.12 ENSMUST00000056157.13 ENSMUST00000056157.2 ENSMUST00000056157.3 ENSMUST00000056157.4 ENSMUST00000056157.5 ENSMUST00000056157.6 ENSMUST00000056157.7 ENSMUST00000056157.8 ENSMUST00000056157.9 MLKL_MOUSE Mlkl NM_001310613 Q8CIJ5 Q9D2Y4 uc009nme.1 uc009nme.2 uc009nme.3 uc009nme.4 uc009nme.5 This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]. Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:23835476, PubMed:27321907, PubMed:24012422, PubMed:24019532, PubMed:32200799, PubMed:32296175). Does not have protein kinase activity (PubMed:24012422). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:23835476, PubMed:27321907, PubMed:24012422, PubMed:24019532). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799, PubMed:32296175). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (By similarity). Activated via binding to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which mediates the release of an N-terminal auto-inhibitory region (By similarity). Activation requires not only RIPK3-dependent phosphorylation but also binding to highly phosphorylated inositol phosphates (By similarity). Homooligomer (By similarity). Homotrimer; forms homotrimers on necroptosis induction (By similarity). Upon TNF-induced necrosis, forms in complex with PGAM5, RIPK1 and RIPK3 (By similarity). Within this complex, may play a role in the proper targeting of RIPK1-RIPK3 to its downstream effector PGAM5 (By similarity). Interacts with RIPK3; the interaction is direct and promotes its phosphorylation and subsequent activation (PubMed:22265413, PubMed:23612963, PubMed:27321907, PubMed:24012422, PubMed:24095729). Q9D2Y4; Q9QZL0: Ripk3; NbExp=3; IntAct=EBI-5401970, EBI-2367423; Cytoplasm ll membrane Nucleus te=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (By similarity). Localizes to the nucleus in response to orthomyxoviruses infection (PubMed:32200799). Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q9D2Y4-1; Sequence=Displayed; Name=2 ; IsoId=Q9D2Y4-2; Sequence=VSP_052132; Highly expressed in thymus, colon, intestine, liver, spleen and lung. Expressed at much lower level in skeletal muscle, heart and kidney. Not detected in brain. The coiled coil region 2 is responsible for homotrimerization. The protein kinase domain is catalytically inactive but contains an unusual pseudoactive site with an interaction between Lys- 219 and Gln-343 residues (PubMed:24012422, PubMed:24095729). Upon phosphorylation by RIPK3, undergoes an active conformation (PubMed:24012422, PubMed:24095729). Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis (PubMed:24012422, PubMed:24095729, PubMed:32200799). It also induces homotrimerization and localization to the plasma membrane (By similarity). No visible phenotype: mice are viable, fertile and do not developmental or homeostatic phenotype in the absence of overt stress (PubMed:23835476, PubMed:24012422). However, these mice are resistant to TNF-induced necroptosis (PubMed:23835476, PubMed:24012422). At a modestly lethal dose of influenza A virus (IAV), mice do not display increased rates of mortality (PubMed:27321907, PubMed:32200799). Perinatal lethality observed in Ripk1 knockout mice is rescued in knockout mice lacking both Ripk1 and Mlkl (PubMed:27819681). In contrast to human protein, not inhibited by necrosulfonamide, because a Trp residue is present instead of a Cys in position 85. Interaction with RIPK3 is species specific: mouse MLKL only interacts with mouse RIPK3 and not human RIPK3. Belongs to the protein kinase superfamily. nucleotide binding protein binding ATP binding cytoplasm plasma membrane protein phosphorylation cell surface receptor signaling pathway programmed cell death membrane protein kinase binding identical protein binding macromolecular complex binding protein homotrimerization necroptotic process protein kinase activity uc009nme.1 uc009nme.2 uc009nme.3 uc009nme.4 uc009nme.5 
ENSMUST00000056176.8 Vav2 ENSMUST00000056176.8 vav 2 oncogene, transcript variant 1 (from RefSeq NM_009500.2) A2AH49 ENSMUST00000056176.1 ENSMUST00000056176.2 ENSMUST00000056176.3 ENSMUST00000056176.4 ENSMUST00000056176.5 ENSMUST00000056176.6 ENSMUST00000056176.7 NM_009500 Q60992 VAV2_MOUSE uc008ixh.1 uc008ixh.2 uc008ixh.3 uc008ixh.4 This gene encodes a member of the Vav family of Rho guanine nucleotide exchange factors. Vav family proteins are involved in the development and activation of lymphocytes, and the encoded protein may also be involved in angiogenesis. Disruption of this gene in mice is associated with heart, artery, and kidney defects, as well as tachycardia and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. Guanine nucleotide exchange factor for the Rho family of Ras- related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with NEK3 and PRLR and this interaction is prolactin- dependent (By similarity). Interacts with SSX2IP. Phosphorylated on tyrosine residues in response to FGR activation. angiogenesis phosphotyrosine binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding protein binding cytoplasm cytosol plasma membrane small GTPase mediated signal transduction regulation of cell size cell migration cell projection assembly lamellipodium assembly regulation of Rho protein signal transduction intracellular signal transduction regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity metal ion binding uc008ixh.1 uc008ixh.2 uc008ixh.3 uc008ixh.4 
ENSMUST00000056181.7 Snx21 ENSMUST00000056181.7 sorting nexin family member 21, transcript variant 1 (from RefSeq NM_133924.4) ENSMUST00000056181.1 ENSMUST00000056181.2 ENSMUST00000056181.3 ENSMUST00000056181.4 ENSMUST00000056181.5 ENSMUST00000056181.6 NM_133924 Q3UR97 SNX21_MOUSE Snx21 uc008nwc.1 uc008nwc.2 uc008nwc.3 Binds to membranes enriched in phosphatidylinositol 3- phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate (PubMed:25882846). May be involved in several stages of intracellular trafficking. Monomer. Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)). Belongs to the sorting nexin family. phosphatidylinositol-4,5-bisphosphate binding endosome biological_process lipid binding protein transport membrane cytoplasmic vesicle membrane cytoplasmic vesicle early endosome membrane phosphatidylinositol-3-phosphate binding phosphatidylinositol binding uc008nwc.1 uc008nwc.2 uc008nwc.3 
ENSMUST00000056184.2 Bhlha9 ENSMUST00000056184.2 basic helix-loop-helix family, member a9 (from RefSeq NM_177182.4) BHA09_MOUSE Bhlhf42 ENSMUST00000056184.1 NM_177182 Q5RJB0 Q80ZL8 Q8BLP5 uc007kfx.1 uc007kfx.2 Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis. Heterodimer. Efficient DNA binding requires dimerization with another bHLH protein. Interacts with TCF3, TCF4, and TCF12. Nucleus At 10.5 dpc, expressed in forelimb and hindlimb buds, in the distal mesenchyme below the apical ectodermal ridge. At 11.5 dpc, expression is restricted to the subridge mesenchymal layer, as well as in the dorsal and ventral regions of the developing limbs. Sequence=AAH48728.1; Type=Erroneous initiation; Evidence=; Sequence=BAC31704.1; Type=Erroneous initiation; Evidence=; DNA binding nucleus cytoplasm multicellular organism development protein heterodimerization activity protein dimerization activity uc007kfx.1 uc007kfx.2 
ENSMUST00000056198.4 Pp2d1 ENSMUST00000056198.4 protein phosphatase 2C-like domain containing 1 (from RefSeq NM_173449.3) ENSMUST00000056198.1 ENSMUST00000056198.2 ENSMUST00000056198.3 NM_173449 PP2D1_MOUSE Q8BVT6 uc008czo.1 uc008czo.2 Belongs to the PP2C family. Although it belongs to the protein phosphatase 2C family, it lacks some of the conserved residues that bind manganese, suggesting it has no phosphatase activity. inactivation of MAPK activity catalytic activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity protein dephosphorylation MAP kinase threonine phosphatase activity uc008czo.1 uc008czo.2 
ENSMUST00000056228.8 Sptssa ENSMUST00000056228.8 serine palmitoyltransferase, small subunit A (from RefSeq NM_134054.2) ENSMUST00000056228.1 ENSMUST00000056228.2 ENSMUST00000056228.3 ENSMUST00000056228.4 ENSMUST00000056228.5 ENSMUST00000056228.6 ENSMUST00000056228.7 NM_134054 Q8BHT2 Q8R207 SPTSA_MOUSE Sptssa Ssspta uc007nnt.1 uc007nnt.2 uc007nnt.3 Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSA stimulates the catalytic activity and plays a role in substrate specificity, which depends upon the overall complex composition. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Independently of its action as a SPT component, may be involved in MBOAT7 localization to mitochondria-associated membranes, a membrane bridge between the endoplasmic reticulum and mitochondria, may hence affect MBOAT7- catalyzed incorporation of arachidonic acid into phosphatidylinositol. Lipid metabolism; sphingolipid metabolism. Component of the serine palmitoyltransferase (SPT) complex, which is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. The heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core of the enzyme, while SPTSSA or SPTSSB subunits determine substrate specificity. SPT also interacts with ORMDL proteins, especially ORMDL3, which negatively regulate SPT activity in the presence of ceramides. Interacts with MBOAT7; the interaction plays a role in MBOAT7 localization to mitochondria-associated membranes. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the SPTSS family. SPTSSA subfamily. It is uncertain whether Met-1 or Met-4 is the initiator. Sequence=AAH22674.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC25023.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC25026.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC25233.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC25555.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; serine C-palmitoyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process sphingolipid metabolic process protein localization membrane integral component of membrane serine C-palmitoyltransferase complex ceramide biosynthetic process uc007nnt.1 uc007nnt.2 uc007nnt.3 
ENSMUST00000056237.15 Prmt9 ENSMUST00000056237.15 protein arginine methyltransferase 9, transcript variant 1 (from RefSeq NM_001081240.4) ENSMUST00000056237.1 ENSMUST00000056237.10 ENSMUST00000056237.11 ENSMUST00000056237.12 ENSMUST00000056237.13 ENSMUST00000056237.14 ENSMUST00000056237.2 ENSMUST00000056237.3 ENSMUST00000056237.4 ENSMUST00000056237.5 ENSMUST00000056237.6 ENSMUST00000056237.7 ENSMUST00000056237.8 ENSMUST00000056237.9 F8WIU7 F8WIU7_MOUSE NM_001081240 Prmt10 Prmt9 uc009mhq.1 uc009mhq.2 cytoplasm mRNA processing protein methylation methyltransferase activity protein-arginine N-methyltransferase activity transferase activity peptidyl-arginine methylation, to symmetrical-dimethyl arginine methylation protein-arginine omega-N symmetric methyltransferase activity peptidyl-arginine N-methylation uc009mhq.1 uc009mhq.2 
ENSMUST00000056246.8 Zfp954 ENSMUST00000056246.8 zinc finger protein 954 (from RefSeq NM_172738.3) 5730403M16Rik ENSMUST00000056246.1 ENSMUST00000056246.2 ENSMUST00000056246.3 ENSMUST00000056246.4 ENSMUST00000056246.5 ENSMUST00000056246.6 ENSMUST00000056246.7 NM_172738 Q7TNU5 Q7TNU5_MOUSE Zfp954 uc012exo.1 uc012exo.2 uc012exo.3 Nucleus nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc012exo.1 uc012exo.2 uc012exo.3 
ENSMUST00000056256.3 4933415A04Rik ENSMUST00000056256.3 4933415A04Rik (from geneSymbol) ENSMUST00000056256.1 ENSMUST00000056256.2 LF198444 uc287xnn.1 uc287xnn.2 uc287xnn.1 uc287xnn.2 
ENSMUST00000056288.7 AI467606 ENSMUST00000056288.7 expressed sequence AI467606 (from RefSeq NM_178901.3) CP054_MOUSE ENSMUST00000056288.1 ENSMUST00000056288.2 ENSMUST00000056288.3 ENSMUST00000056288.4 ENSMUST00000056288.5 ENSMUST00000056288.6 NM_178901 Q6P3A6 Q8C708 uc009juf.1 uc009juf.2 uc009juf.3 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009juf.1 uc009juf.2 uc009juf.3 
ENSMUST00000056312.10 Serinc4 ENSMUST00000056312.10 serine incorporator 4, transcript variant 1 (from RefSeq NM_001025371.2) ENSMUST00000056312.1 ENSMUST00000056312.2 ENSMUST00000056312.3 ENSMUST00000056312.4 ENSMUST00000056312.5 ENSMUST00000056312.6 ENSMUST00000056312.7 ENSMUST00000056312.8 ENSMUST00000056312.9 NM_001025371 Q5XK03 Q8C8U1 SERC4_MOUSE uc008lze.1 uc008lze.2 uc008lze.3 Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids. Membrane ; Multi-pass membrane protein Belongs to the TDE1 family. Sequence=BAC31945.1; Type=Frameshift; Evidence=; lipid metabolic process phospholipid biosynthetic process membrane integral component of membrane uc008lze.1 uc008lze.2 uc008lze.3 
ENSMUST00000056328.6 Rnf26 ENSMUST00000056328.6 ring finger protein 26 (from RefSeq NM_153762.3) ENSMUST00000056328.1 ENSMUST00000056328.2 ENSMUST00000056328.3 ENSMUST00000056328.4 ENSMUST00000056328.5 F6SS41 NM_153762 Q5PR90 Q8BUH7 Q8BZY8 Q99KC1 RNF26_MOUSE Rnf26 uc009pbu.1 uc009pbu.2 uc009pbu.3 uc009pbu.4 E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with INCA1. Interacts with TMEM43, ENDOD1, TMEM33 and TMED1 to form a complex capable of modulating innate immune signaling through the cGAS-STING pathway. Interacts with UBE2J1; this interaction is important for SQSTM1 ubiquitination. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BUH7-1; Sequence=Displayed; Name=2; IsoId=Q8BUH7-2; Sequence=VSP_042390, VSP_042391; endoplasmic reticulum endoplasmic reticulum membrane endosome organization membrane integral component of membrane protein ubiquitination transferase activity regulation of type I interferon production metal ion binding negative regulation of defense response to virus ubiquitin protein ligase activity protein K11-linked ubiquitination protein localization to perinuclear region of cytoplasm uc009pbu.1 uc009pbu.2 uc009pbu.3 uc009pbu.4 
ENSMUST00000056329.7 Klk14 ENSMUST00000056329.7 kallikrein related-peptidase 14 (from RefSeq NM_174866.4) ENSMUST00000056329.1 ENSMUST00000056329.2 ENSMUST00000056329.3 ENSMUST00000056329.4 ENSMUST00000056329.5 ENSMUST00000056329.6 Gk14 KLK14_MOUSE NM_174866 Q8CGR5 uc009gni.1 uc009gni.2 uc009gni.3 uc009gni.4 This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The encoded protein is a precursor that undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. The encoded enzyme was found to activate the complement pathway by cleavage of C3 to release C3a anaphylotoxin. This gene is one of the several glandular kallikrein genes located in a cluster on chromosome 7. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB981046.1, BC044756.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis (By similarity). Inhibited by SERPINA1, SERPINC1, SERPINE1, SERPINF2, aprotinin, soybean, trypsin inhibitor and leupeptin. Inhibited by serine protease inhibitor SPINK5. Has an autoproteolytic activity which may have a regulatory effect. Activated by citrate and inhibited by zinc and to a lower extent by manganese (By similarity). Secreted, extracellular space Proteolytic cleavage of the activation peptide produces the active enzyme. Belongs to the peptidase S1 family. Kallikrein subfamily. serine-type endopeptidase activity extracellular region extracellular space proteolysis peptidase activity serine-type peptidase activity fertilization hydrolase activity secretory granule negative regulation of G-protein coupled receptor protein signaling pathway positive regulation of G-protein coupled receptor protein signaling pathway epidermis morphogenesis seminal clot liquefaction uc009gni.1 uc009gni.2 uc009gni.3 uc009gni.4 
ENSMUST00000056331.8 Adam20 ENSMUST00000056331.8 a disintegrin and metallopeptidase domain 20 (from RefSeq NM_001009548.2) 4930529F22Rik Adam20 Adam38 ENSMUST00000056331.1 ENSMUST00000056331.2 ENSMUST00000056331.3 ENSMUST00000056331.4 ENSMUST00000056331.5 ENSMUST00000056331.6 ENSMUST00000056331.7 NM_001009548 Q7M763 Q7M763_MOUSE uc012gcp.1 uc012gcp.2 Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function metalloendopeptidase activity cellular_component proteolysis biological_process metallopeptidase activity membrane integral component of membrane uc012gcp.1 uc012gcp.2 
ENSMUST00000056336.2 Oprd1 ENSMUST00000056336.2 opioid receptor, delta 1 (from RefSeq NM_013622.3) ENSMUST00000056336.1 NM_013622 OPRD_MOUSE P32300 uc008vap.1 uc008vap.2 G-protein coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. May form homooligomers. Forms a heterodimer with OPRM1 (PubMed:18836069). Interacts with GPRASP1 (By similarity). Interacts with RTP4; the interaction promotes cell surface localization of the OPRD1-OPRM1 heterodimer (PubMed:18836069). P32300; Q9ER80: Rtp4; NbExp=2; IntAct=EBI-2615936, EBI-15731539; Cell membrane ulti-pass membrane protein Brain, with high concentrations in the basal ganglia and limbic regions. Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4. Mice are born at the expected Mendelian rate; they show no obvious phenotype and are fertile. Mutant mice show decreased analgesia in response to opioids, such as deltorphin-2. They do not develop analgesic tolerance to morphine. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity opioid receptor activity protein binding cytoplasm plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway neuropeptide signaling pathway adult locomotory behavior negative regulation of gene expression membrane integral component of membrane integral component of synaptic vesicle membrane intrinsic component of plasma membrane negative regulation of protein complex assembly vesicle negative regulation of protein oligomerization dendrite membrane positive regulation of peptidyl-serine phosphorylation receptor serine/threonine kinase binding opioid receptor signaling pathway enkephalin receptor activity peptide binding eating behavior neuropeptide binding axon terminus membrane raft postsynaptic membrane regulation of mitochondrial membrane potential regulation of calcium ion transport regulation of sensory perception of pain cellular response to growth factor stimulus cellular response to hypoxia cellular response to toxic substance spine apparatus neuronal dense core vesicle integral component of presynaptic membrane integral component of postsynaptic density membrane adenylate cyclase-activating dopamine receptor signaling pathway uc008vap.1 uc008vap.2 
ENSMUST00000056344.5 Vwc2 ENSMUST00000056344.5 BMP antagonist which may play a role in neural development. Promotes cell adhesion. (from UniProt Q8C8N3) B2RQ98 DQ421811 ENSMUST00000056344.1 ENSMUST00000056344.2 ENSMUST00000056344.3 ENSMUST00000056344.4 Q5SSH5 Q8C8N3 VWC2_MOUSE uc287wqe.1 uc287wqe.2 BMP antagonist which may play a role in neural development. Promotes cell adhesion. Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Secreted, extracellular space, extracellular matrix, basement membrane. Synapse Predominantly expressed in the brain (at protein level). It is expressed in the neurons but not the glial cells. At 12.5 dpc, predominantly expressed in the developing diencephalon. At 16.5 dpc and 18.5 dpc, expressed in the brain, spinal cord, developing neural tubes and tongue but not in the cerebral cortex. At 16.5 dpc, present in developing oral and tooth germ epithelia (at protein level). Sequence=CAI25053.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function extracellular region basement membrane interstitial matrix extracellular space positive regulation of cell-substrate adhesion cell junction negative regulation of BMP signaling pathway extracellular matrix AMPA glutamate receptor complex synapse positive regulation of neuron differentiation uc287wqe.1 uc287wqe.2 
ENSMUST00000056355.9 Nat8l ENSMUST00000056355.9 N-acetyltransferase 8-like (from RefSeq NM_001001985.3) A0A0R4J0R4 A0A0R4J0R4_MOUSE ENSMUST00000056355.1 ENSMUST00000056355.2 ENSMUST00000056355.3 ENSMUST00000056355.4 ENSMUST00000056355.5 ENSMUST00000056355.6 ENSMUST00000056355.7 ENSMUST00000056355.8 NM_001001985 Nat8l uc008xbs.1 uc008xbs.2 Reaction=acetyl-CoA + L-aspartate = CoA + H(+) + N-acetyl-L-aspartate; Xref=Rhea:RHEA:14165, ChEBI:CHEBI:15378, ChEBI:CHEBI:16953, ChEBI:CHEBI:29991, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14166; Evidence=; Cytoplasm Endoplasmic reticulum membrane ; Single- pass membrane protein Membrane ; Single-pass membrane protein Mitochondrion membrane ; Single-pass membrane protein Belongs to the camello family. cytoplasm mitochondrion N-acetyltransferase activity membrane integral component of membrane aspartate N-acetyltransferase activity mitochondrial membrane uc008xbs.1 uc008xbs.2 
ENSMUST00000056362.3 Krt34 ENSMUST00000056362.3 keratin 34 (from RefSeq NM_027563.4) ENSMUST00000056362.1 ENSMUST00000056362.2 Ha4 KRT34_MOUSE Krt1-4 Krt34 NM_027563 Q9D646 uc007lkc.1 uc007lkc.2 uc007lkc.3 uc007lkc.4 The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. [provided by RefSeq, Sep 2015]. ##Evidence-Data-START## Transcript exon combination :: AK014631.1, BC125420.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849377 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Expressed in the hair root in the hair shaft cuticle and cortex. There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). Belongs to the intermediate filament family. structural molecule activity intermediate filament uc007lkc.1 uc007lkc.2 uc007lkc.3 uc007lkc.4 
ENSMUST00000056364.3 Or8b3 ENSMUST00000056364.3 olfactory receptor family 8 subfamily B member 3 (from RefSeq NM_146869.2) ENSMUST00000056364.1 ENSMUST00000056364.2 Mor164-1 NM_146869 OR8B3_MOUSE Olfr147 Olfr7 Or8b3 Q60886 Q7TRD2 Q8VGC9 uc292fxy.1 uc292fxy.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB173731.1, CB173176.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fxy.1 uc292fxy.2 
ENSMUST00000056365.9 Evc2 ENSMUST00000056365.9 EvC ciliary complex subunit 2 (from RefSeq NM_145920.3) ENSMUST00000056365.1 ENSMUST00000056365.2 ENSMUST00000056365.3 ENSMUST00000056365.4 ENSMUST00000056365.5 ENSMUST00000056365.6 ENSMUST00000056365.7 ENSMUST00000056365.8 LBN_MOUSE Lbn NM_145920 Q8BRF3 Q8K1G2 uc008xfs.1 uc008xfs.2 uc008xfs.3 uc008xfs.4 Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:21356043, PubMed:24582806). Plays a critical role in bone formation and skeletal development (PubMed:21356043). May be involved in early embryonic morphogenesis (PubMed:21356043). Component of the EvC complex composed of EFCAB7, IQCE, EVC2 and EVC; built from two subcomplexes, EVC2:EVC and EFCAB7:IQCE (PubMed:24582806). Interacts with EVC (PubMed:21356043, PubMed:24582806). Interacts (via N-terminal end) with EFCAB7 (PubMed:24582806). Interacts (via N-terminal end) with IQCE (PubMed:24582806). Cell membrane ; Single-pass type I membrane protein Cytoplasm, cytoskeleton, cilium basal body Cell projection, cilium Cell projection, cilium membrane Nucleus Note=The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner (PubMed:24582806). Expressed in long and cranial bones, kidney and heart. Strongly expressed in proliferating chondrocytes, osteoblasts and osteoclasts. Found in the embryo at day 7 dpc, 11 dpc, 15 dpc, and 17 dpc. At the limb bud formation stage 11 dpc, it is expressed in fore- and hindlimb buds, branchial arches, and facial primordia. Sequence=BAC32167.1; Type=Erroneous initiation; Evidence=; protein binding nucleus cytoplasm cytoskeleton plasma membrane cilium smoothened signaling pathway membrane integral component of membrane cell projection ciliary membrane plasma membrane protein complex uc008xfs.1 uc008xfs.2 uc008xfs.3 uc008xfs.4 
ENSMUST00000056370.13 Pmf1 ENSMUST00000056370.13 polyamine-modulated factor 1, transcript variant 1 (from RefSeq NM_025928.5) ENSMUST00000056370.1 ENSMUST00000056370.10 ENSMUST00000056370.11 ENSMUST00000056370.12 ENSMUST00000056370.2 ENSMUST00000056370.3 ENSMUST00000056370.4 ENSMUST00000056370.5 ENSMUST00000056370.6 ENSMUST00000056370.7 ENSMUST00000056370.8 ENSMUST00000056370.9 NM_025928 PMF1_MOUSE Pmf1 Q3UCB8 Q8K237 Q924B3 Q9CPV5 Q9D6E2 uc008pva.1 uc008pva.2 uc008pva.3 uc008pva.4 Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (By similarity). May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT. Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Interacts with COPS7A (By similarity). Interacts via its coiled-coil domain with the leucine-zipper domain of NFE2L2. The interaction with NFE2L2 is required for the transcriptional regulation of SSAT. Nucleus Chromosome, centromere, kinetochore Note=Associated with the kinetochore. Event=Alternative splicing; Named isoforms=2; Name=1 ; Synonyms=PMF-1L ; IsoId=Q9CPV5-1; Sequence=Displayed; Name=2 ; Synonyms=PMF-1S ; IsoId=Q9CPV5-2; Sequence=VSP_052141; By polyamine analogs in M1 myeloid leukemia cells. MIS12/MIND type complex chromosome, centromeric region kinetochore condensed chromosome kinetochore nuclear MIS12/MIND complex transcription coactivator activity protein binding nucleus nucleoplasm chromosome Golgi apparatus cell cycle chromosome segregation intracellular membrane-bounded organelle leucine zipper domain binding cell division positive regulation of nucleic acid-templated transcription uc008pva.1 uc008pva.2 uc008pva.3 uc008pva.4 
ENSMUST00000056398.11 Lsm8 ENSMUST00000056398.11 LSM8 homolog, U6 small nuclear RNA associated (from RefSeq NM_133939.1) ENSMUST00000056398.1 ENSMUST00000056398.10 ENSMUST00000056398.2 ENSMUST00000056398.3 ENSMUST00000056398.4 ENSMUST00000056398.5 ENSMUST00000056398.6 ENSMUST00000056398.7 ENSMUST00000056398.8 ENSMUST00000056398.9 LSM8_MOUSE NM_133939 Q3TIX3 Q6ZWM4 uc009bao.1 uc009bao.2 uc009bao.3 Plays a role in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Nucleus Belongs to the snRNP Sm proteins family. mRNA splicing, via spliceosome RNA binding nucleus spliceosomal complex U6 snRNP mRNA processing RNA splicing RNA metabolic process U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome uc009bao.1 uc009bao.2 uc009bao.3 
ENSMUST00000056406.7 Fam78a ENSMUST00000056406.7 family with sequence similarity 78, member A, transcript variant 1 (from RefSeq NM_175511.5) ENSMUST00000056406.1 ENSMUST00000056406.2 ENSMUST00000056406.3 ENSMUST00000056406.4 ENSMUST00000056406.5 ENSMUST00000056406.6 FA78A_MOUSE NM_175511 Q8C552 uc008jek.1 uc008jek.2 uc008jek.3 Belongs to the FAM78 family. molecular_function cellular_component biological_process uc008jek.1 uc008jek.2 uc008jek.3 
ENSMUST00000056410.11 Gemin8 ENSMUST00000056410.11 gem nuclear organelle associated protein 8, transcript variant 2 (from RefSeq NM_146238.4) B1AVP4 ENSMUST00000056410.1 ENSMUST00000056410.10 ENSMUST00000056410.2 ENSMUST00000056410.3 ENSMUST00000056410.4 ENSMUST00000056410.5 ENSMUST00000056410.6 ENSMUST00000056410.7 ENSMUST00000056410.8 ENSMUST00000056410.9 Fam51a1 GEMI8_MOUSE NM_146238 Q3TUT1 Q8BHE1 Q8R3W9 uc009uwc.1 uc009uwc.2 uc009uwc.3 The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre- mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP (By similarity). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG (By similarity). Interacts with GEMIN6; the interaction is direct (By similarity). Interacts with GEMIN7; the interaction is direct (By similarity). Interacts with SMN1; the interaction is direct (By similarity). Interacts with GEMIN4; the interaction is direct (By similarity). Nucleus, gem Cytoplasm Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm (By similarity). Widely expressed in embryonic tissues (at protein level). Sequence=AAH23488.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; spliceosomal snRNP assembly nucleus cytoplasm cytosol mRNA processing RNA splicing SMN complex SMN-Sm protein complex Gemini of coiled bodies uc009uwc.1 uc009uwc.2 uc009uwc.3 
ENSMUST00000056427.10 Tubb2a ENSMUST00000056427.10 tubulin, beta 2A class IIA (from RefSeq NM_009450.2) ENSMUST00000056427.1 ENSMUST00000056427.2 ENSMUST00000056427.3 ENSMUST00000056427.4 ENSMUST00000056427.5 ENSMUST00000056427.6 ENSMUST00000056427.7 ENSMUST00000056427.8 ENSMUST00000056427.9 NM_009450 Q7TMM9 TBB2A_MOUSE Tubb2 uc007qbb.1 uc007qbb.2 uc007qbb.3 uc007qbb.4 uc007qbb.5 uc007qbb.6 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Part of a complex composed at least of ASH2L, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity). Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with ZNRF1. Cytoplasm, cytoskeleton The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation. Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility (PubMed:33414192). Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:15890843). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (PubMed:23897886). Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle neuron migration GTPase activity structural constituent of cytoskeleton GTP binding cytoplasm cytoskeleton microtubule microtubule-based process uc007qbb.1 uc007qbb.2 uc007qbb.3 uc007qbb.4 uc007qbb.5 uc007qbb.6 
ENSMUST00000056433.7 Gpr107 ENSMUST00000056433.7 G protein-coupled receptor 107 (from RefSeq NM_178760.4) ENSMUST00000056433.1 ENSMUST00000056433.2 ENSMUST00000056433.3 ENSMUST00000056433.4 ENSMUST00000056433.5 ENSMUST00000056433.6 GP107_MOUSE Kiaa1624 NM_178760 Q6ZPL4 Q8BM58 Q8BMN6 Q8BTW1 Q8BUV8 uc008jdp.1 uc008jdp.2 uc008jdp.3 uc008jdp.4 Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). Cell membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Cleaved by FURIN to yield two fragments that remain associated via a disulfide bond. Belongs to the LU7TM family. protein binding nucleoplasm early endosome Golgi apparatus plasma membrane membrane integral component of membrane clathrin-coated vesicle clathrin heavy chain binding clathrin-dependent endocytosis uc008jdp.1 uc008jdp.2 uc008jdp.3 uc008jdp.4 
ENSMUST00000056442.12 Slc6a5 ENSMUST00000056442.12 solute carrier family 6 (neurotransmitter transporter, glycine), member 5, transcript variant a (from RefSeq NM_001146013.2) B2RQX9 B2RQX9_MOUSE ENSMUST00000056442.1 ENSMUST00000056442.10 ENSMUST00000056442.11 ENSMUST00000056442.2 ENSMUST00000056442.3 ENSMUST00000056442.4 ENSMUST00000056442.5 ENSMUST00000056442.6 ENSMUST00000056442.7 ENSMUST00000056442.8 ENSMUST00000056442.9 NM_001146013 Slc6a5 uc009hbv.1 uc009hbv.2 uc009hbv.3 uc009hbv.4 uc009hbv.5 Membrane ; Multi- pass membrane protein Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. neurotransmitter uptake neurotransmitter:sodium symporter activity plasma membrane glycine transmembrane transporter activity symporter activity glycine:sodium symporter activity glycine transport membrane integral component of membrane synaptic transmission, glycinergic integral component of presynaptic membrane glycine import into cell uc009hbv.1 uc009hbv.2 uc009hbv.3 uc009hbv.4 uc009hbv.5 
ENSMUST00000056449.9 Arhgap30 ENSMUST00000056449.9 Rho GTPase activating protein 30 (from RefSeq NM_001005508.2) Arhgap30 E9QMX7 E9QMX7_MOUSE ENSMUST00000056449.1 ENSMUST00000056449.2 ENSMUST00000056449.3 ENSMUST00000056449.4 ENSMUST00000056449.5 ENSMUST00000056449.6 ENSMUST00000056449.7 ENSMUST00000056449.8 NM_001005508 uc007doh.1 uc007doh.2 uc007doh.3 uc007doh.4 uc007doh.5 signal transduction intracellular membrane-bounded organelle uc007doh.1 uc007doh.2 uc007doh.3 uc007doh.4 uc007doh.5 
ENSMUST00000056460.4 Pudp ENSMUST00000056460.4 pseudouridine 5'-phosphatase (from RefSeq NM_026108.3) A0A0C3SFZ4 A0A0C3SFZ4_MOUSE ENSMUST00000056460.1 ENSMUST00000056460.2 ENSMUST00000056460.3 Hdhd1a NM_026108 Pudp uc008ewy.1 uc008ewy.2 uc008ewy.3 uc008ewy.4 hydrolase activity uc008ewy.1 uc008ewy.2 uc008ewy.3 uc008ewy.4 
ENSMUST00000056470.10 Zfp459 ENSMUST00000056470.10 zinc finger protein 459 (from RefSeq NM_177811.4) ENSMUST00000056470.1 ENSMUST00000056470.2 ENSMUST00000056470.3 ENSMUST00000056470.4 ENSMUST00000056470.5 ENSMUST00000056470.6 ENSMUST00000056470.7 ENSMUST00000056470.8 ENSMUST00000056470.9 NM_177811 Q8BZ17 Q8BZ17_MOUSE Zfp459 uc007rat.1 uc007rat.2 uc007rat.3 uc007rat.4 uc007rat.5 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc007rat.1 uc007rat.2 uc007rat.3 uc007rat.4 uc007rat.5 
ENSMUST00000056474.7 Fam221b ENSMUST00000056474.7 family with sequence similarity 221, member B (from RefSeq NM_175517.3) ENSMUST00000056474.1 ENSMUST00000056474.2 ENSMUST00000056474.3 ENSMUST00000056474.4 ENSMUST00000056474.5 ENSMUST00000056474.6 F221B_MOUSE NM_175517 Q0VD71 Q8BGP2 Q8C627 uc008sqt.1 uc008sqt.2 uc008sqt.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C627-1; Sequence=Displayed; Name=2; IsoId=Q8C627-2; Sequence=VSP_029102, VSP_029103; Belongs to the FAM221 family. molecular_function cellular_component biological_process uc008sqt.1 uc008sqt.2 uc008sqt.3 
ENSMUST00000056480.10 Hrh3 ENSMUST00000056480.10 histamine receptor H3, transcript variant 1 (from RefSeq NM_133849.4) ENSMUST00000056480.1 ENSMUST00000056480.2 ENSMUST00000056480.3 ENSMUST00000056480.4 ENSMUST00000056480.5 ENSMUST00000056480.6 ENSMUST00000056480.7 ENSMUST00000056480.8 ENSMUST00000056480.9 Hrh3 NM_133849 Q540P3 Q540P3_MOUSE uc008oij.1 uc008oij.2 uc008oij.3 uc008oij.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. regulation of neurotransmitter levels G-protein coupled receptor activity histamine receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc008oij.1 uc008oij.2 uc008oij.3 uc008oij.4 
ENSMUST00000056495.14 Dnmt3b ENSMUST00000056495.14 Nucleus (from UniProt Q3KR45) AF151969 Dnmt3b ENSMUST00000056495.1 ENSMUST00000056495.10 ENSMUST00000056495.11 ENSMUST00000056495.12 ENSMUST00000056495.13 ENSMUST00000056495.2 ENSMUST00000056495.3 ENSMUST00000056495.4 ENSMUST00000056495.5 ENSMUST00000056495.6 ENSMUST00000056495.7 ENSMUST00000056495.8 ENSMUST00000056495.9 Q3KR45 Q3KR45_MOUSE uc290bmy.1 uc290bmy.2 Nucleus Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. response to hypoxia chromatin binding nucleus DNA methylation methyltransferase activity DNA-methyltransferase activity response to toxic substance response to ionizing radiation regulation of gene expression response to activity transferase activity response to caffeine methylation response to estradiol response to vitamin A response to cocaine response to drug histone deacetylase binding positive regulation of neuron differentiation cellular response to hyperoxia cellular response to dexamethasone stimulus uc290bmy.1 uc290bmy.2 
ENSMUST00000056499.4 Or8g24 ENSMUST00000056499.4 olfactory receptor family 8 subfamily G member 24 (from RefSeq NM_146438.1) ENSMUST00000056499.1 ENSMUST00000056499.2 ENSMUST00000056499.3 NM_146438 Olfr938 Or8g24 Q9EQ93 Q9EQ93_MOUSE uc009oxp.1 uc009oxp.2 uc009oxp.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oxp.1 uc009oxp.2 uc009oxp.3 
ENSMUST00000056508.12 Clcn3 ENSMUST00000056508.12 chloride channel, voltage-sensitive 3, transcript variant c (from RefSeq NM_173876.4) Clcn3 ENSMUST00000056508.1 ENSMUST00000056508.10 ENSMUST00000056508.11 ENSMUST00000056508.2 ENSMUST00000056508.3 ENSMUST00000056508.4 ENSMUST00000056508.5 ENSMUST00000056508.6 ENSMUST00000056508.7 ENSMUST00000056508.8 ENSMUST00000056508.9 NM_173876 Q8K4W8 Q8K4W8_MOUSE uc009ltk.1 uc009ltk.2 uc009ltk.3 uc009ltk.4 Cell membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Membrane ; Multi- pass membrane protein Belongs to the chloride channel (TC 2.A.49) family. ClC- 3/CLCN3 subfamily. voltage-gated chloride channel activity ion transport chloride transport membrane integral component of membrane transmembrane transport chloride transmembrane transport uc009ltk.1 uc009ltk.2 uc009ltk.3 uc009ltk.4 
ENSMUST00000056521.12 Bmerb1 ENSMUST00000056521.12 bMERB domain containing 1 (from RefSeq NM_144518.3) ENSMUST00000056521.1 ENSMUST00000056521.10 ENSMUST00000056521.11 ENSMUST00000056521.2 ENSMUST00000056521.3 ENSMUST00000056521.4 ENSMUST00000056521.5 ENSMUST00000056521.6 ENSMUST00000056521.7 ENSMUST00000056521.8 ENSMUST00000056521.9 MERB1_MOUSE NM_144518 Q3UVX0 Q8R1Y2 uc007ygu.1 uc007ygu.2 uc007ygu.3 protein binding negative regulation of microtubule depolymerization microtubule cytoskeleton negative regulation of cell motility involved in cerebral cortex radial glia guided migration uc007ygu.1 uc007ygu.2 uc007ygu.3 
ENSMUST00000056522.5 Pcdhb2 ENSMUST00000056522.5 protocadherin beta 2 (from RefSeq NM_053127.2) ENSMUST00000056522.1 ENSMUST00000056522.2 ENSMUST00000056522.3 ENSMUST00000056522.4 NM_053127 Pcdhb2 Q91Y00 Q91Y00_MOUSE uc008epn.1 uc008epn.2 uc008epn.3 molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epn.1 uc008epn.2 uc008epn.3 
ENSMUST00000056533.9 Myoz3 ENSMUST00000056533.9 myozenin 3 (from RefSeq NM_133363.4) E9QJU4 E9QJU4_MOUSE ENSMUST00000056533.1 ENSMUST00000056533.2 ENSMUST00000056533.3 ENSMUST00000056533.4 ENSMUST00000056533.5 ENSMUST00000056533.6 ENSMUST00000056533.7 ENSMUST00000056533.8 Myoz3 NM_133363 uc012bdl.1 uc012bdl.2 uc012bdl.3 uc012bdl.4 Belongs to the myozenin family. uc012bdl.1 uc012bdl.2 uc012bdl.3 uc012bdl.4 
ENSMUST00000056549.9 Zfp235 ENSMUST00000056549.9 zinc finger protein 235, transcript variant 2 (from RefSeq NM_019941.3) ENSMUST00000056549.1 ENSMUST00000056549.2 ENSMUST00000056549.3 ENSMUST00000056549.4 ENSMUST00000056549.5 ENSMUST00000056549.6 ENSMUST00000056549.7 ENSMUST00000056549.8 NM_019941 Q499D5 Q499D5_MOUSE Zfp235 uc009fow.1 uc009fow.2 uc009fow.3 Nucleus nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009fow.1 uc009fow.2 uc009fow.3 
ENSMUST00000056558.11 Zfp366 ENSMUST00000056558.11 zinc finger protein 366 (from RefSeq NM_001004149.1) ENSMUST00000056558.1 ENSMUST00000056558.10 ENSMUST00000056558.2 ENSMUST00000056558.3 ENSMUST00000056558.4 ENSMUST00000056558.5 ENSMUST00000056558.6 ENSMUST00000056558.7 ENSMUST00000056558.8 ENSMUST00000056558.9 NM_001004149 Q6NS86 ZN366_MOUSE Zfp366 Znf366 uc007rpl.1 uc007rpl.2 uc007rpl.3 Has transcriptional repression activity. Acts as a corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases. Interacts with ESR1 and NRIP1. Interacts (via PXDLS motif) with CTBP1. Nucleus Expressed in immature and mature dendritic cells (DCs). negative regulation of transcription from RNA polymerase II promoter nucleic acid binding DNA binding transcription corepressor activity nucleus estrogen receptor binding negative regulation of intracellular estrogen receptor signaling pathway response to estrogen metal ion binding uc007rpl.1 uc007rpl.2 uc007rpl.3 
ENSMUST00000056578.7 Bri3 ENSMUST00000056578.7 brain protein I3, transcript variant 1 (from RefSeq NM_018772.4) BRI3_MOUSE ENSMUST00000056578.1 ENSMUST00000056578.2 ENSMUST00000056578.3 ENSMUST00000056578.4 ENSMUST00000056578.5 ENSMUST00000056578.6 NM_018772 P28662 Q501N3 Q9Z1S1 uc009alo.1 uc009alo.2 uc009alo.3 uc009alo.4 Participates in tumor necrosis factor-alpha (TNF)-induced cell death (Ref.4). May be a target of Wnt/beta-catenin signaling in the liver (By similarity). Interacts with BRI3BP. Interacts with MGAT1 and IFITM3 (By similarity). Lysosome membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region Note=Co-localizes with MGAT1 and IFITM3 at the perinuclear region. High expression in cerebral cortex, and in cerebellar cortex. Up-regulated during TNF-mediated inflammation and immunity. Belongs to the BRI3 family. lysosome lysosomal membrane membrane integral component of membrane identical protein binding uc009alo.1 uc009alo.2 uc009alo.3 uc009alo.4 
ENSMUST00000056589.15 Selenov ENSMUST00000056589.15 selenoprotein V (from RefSeq NM_175033.4) BC089491 ENSMUST00000056589.1 ENSMUST00000056589.10 ENSMUST00000056589.11 ENSMUST00000056589.12 ENSMUST00000056589.13 ENSMUST00000056589.14 ENSMUST00000056589.2 ENSMUST00000056589.3 ENSMUST00000056589.4 ENSMUST00000056589.5 ENSMUST00000056589.6 ENSMUST00000056589.7 ENSMUST00000056589.8 ENSMUST00000056589.9 NM_175033 Q5FWB9 Q5FWB9_MOUSE Selenov uc009fyd.1 uc009fyd.2 uc009fyd.3 This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. [provided by RefSeq, Apr 2017]. ##Evidence-Data-START## Transcript exon combination :: BC089491.1, AK077113.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred from conservation protein contains selenocysteine :: PMID: 12775843 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## molecular_function response to selenium ion uc009fyd.1 uc009fyd.2 uc009fyd.3 
ENSMUST00000056601.11 Vps53 ENSMUST00000056601.11 VPS53 GARP complex subunit, transcript variant 1 (from RefSeq NM_026664.4) ENSMUST00000056601.1 ENSMUST00000056601.10 ENSMUST00000056601.2 ENSMUST00000056601.3 ENSMUST00000056601.4 ENSMUST00000056601.5 ENSMUST00000056601.6 ENSMUST00000056601.7 ENSMUST00000056601.8 ENSMUST00000056601.9 NM_026664 Q8C7U0 Q8CCB4 Q8CIA1 Q9CX82 Q9D6T7 VPS53_MOUSE uc007kfa.1 uc007kfa.2 uc007kfa.3 Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (By similarity). Component of the endosome- associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (By similarity). EIPR1 interacts with both EARP and GARP complexes and mediates the recruitment of the GARP complex to the trans-Golgi network (By similarity). Interacts with VPS50 in an EIPR1-independent manner (By similarity). Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Recycling endosome Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CCB4-1; Sequence=Displayed; Name=2; IsoId=Q8CCB4-2; Sequence=VSP_016239; Belongs to the VPS53 family. Sequence=BAB26620.1; Type=Erroneous initiation; Evidence=; GARP complex endosome Golgi apparatus trans-Golgi network cytosol lysosomal transport endosome membrane protein transport membrane endocytic recycling retrograde transport, endosome to Golgi perinuclear region of cytoplasm recycling endosome EARP complex uc007kfa.1 uc007kfa.2 uc007kfa.3 
ENSMUST00000056614.7 Cxcr3 ENSMUST00000056614.7 C-X-C motif chemokine receptor 3 (from RefSeq NM_009910.3) CXCR3_MOUSE Cmkar3 ENSMUST00000056614.1 ENSMUST00000056614.2 ENSMUST00000056614.3 ENSMUST00000056614.4 ENSMUST00000056614.5 ENSMUST00000056614.6 NM_009910 O88410 Q4V9Y6 Q9QWN6 uc009tye.1 uc009tye.2 uc009tye.3 uc009tye.4 This gene encodes a transmembrane protein that functions as a receptor for C-X-R chemokines. Signalling through this protein regulates a variety of biological processes, including inflammation, immunity, and would healing. This protein also plays a role in tumor growth and metastasis. [provided by RefSeq, May 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB003174.1, SRR1660813.263017.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response (By similarity). Binds to CCL21. Homomer. Forms heteromers with ACKR4 (By similarity). Cell membrane ; Multi-pass membrane protein Expresses in lymphoid organs and Th1 cells. Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding. N-glycosylated. Belongs to the G-protein coupled receptor 1 family. angiogenesis negative regulation of endothelial cell proliferation regulation of leukocyte migration G-protein coupled receptor activity chemokine receptor activity plasma membrane chemotaxis inflammatory response immune response signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of cell proliferation external side of plasma membrane cell surface T cell chemotaxis membrane integral component of membrane C-C chemokine receptor activity C-X-C chemokine receptor activity negative regulation of angiogenesis calcium-mediated signaling chemokine binding C-C chemokine binding C-X-C chemokine binding regulation of cell adhesion signaling receptor activity identical protein binding positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter positive regulation of chemotaxis positive regulation of release of sequestered calcium ion into cytosol cell chemotaxis chemokine-mediated signaling pathway chemokine (C-C motif) ligand 11 production negative regulation of execution phase of apoptosis positive regulation of execution phase of apoptosis uc009tye.1 uc009tye.2 uc009tye.3 uc009tye.4 
ENSMUST00000056623.13 Tmem72 ENSMUST00000056623.13 transmembrane protein 72 (from RefSeq NM_178768.4) ENSMUST00000056623.1 ENSMUST00000056623.10 ENSMUST00000056623.11 ENSMUST00000056623.12 ENSMUST00000056623.2 ENSMUST00000056623.3 ENSMUST00000056623.4 ENSMUST00000056623.5 ENSMUST00000056623.6 ENSMUST00000056623.7 ENSMUST00000056623.8 ENSMUST00000056623.9 NM_178768 Q0VGN8 Q3URE2 Q8C3K5 Q8C7L8 Q8C7X5 Q8CC57 TMM72_MOUSE uc009dkr.1 uc009dkr.2 uc009dkr.3 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009dkr.1 uc009dkr.2 uc009dkr.3 
ENSMUST00000056639.8 Lgalsl2 ENSMUST00000056639.8 galectin like 2 (from RefSeq NR_003622.2) ENSMUST00000056639.1 ENSMUST00000056639.2 ENSMUST00000056639.3 ENSMUST00000056639.4 ENSMUST00000056639.5 ENSMUST00000056639.6 ENSMUST00000056639.7 Gm5065 Grpb LEGLB_MOUSE Lgalsl2 Lgalslb NR_003622 Q7TPX9 uc009faf.1 uc009faf.2 uc009faf.3 Does not bind lactose, and may not bind carbohydrates. Monomer. Most of the residues in the galectin domain that have been shown to be critical for carbohydrate-binding in other galectins are not conserved. molecular_function cytoplasm biological_process carbohydrate binding uc009faf.1 uc009faf.2 uc009faf.3 
ENSMUST00000056649.13 Gas2l1 ENSMUST00000056649.13 growth arrest-specific 2 like 1, transcript variant beta (from RefSeq NM_144560.3) ENSMUST00000056649.1 ENSMUST00000056649.10 ENSMUST00000056649.11 ENSMUST00000056649.12 ENSMUST00000056649.2 ENSMUST00000056649.3 ENSMUST00000056649.4 ENSMUST00000056649.5 ENSMUST00000056649.6 ENSMUST00000056649.7 ENSMUST00000056649.8 ENSMUST00000056649.9 GA2L1_MOUSE NM_144560 Q5SVG0 Q8JZP9 Q8K573 uc007hvu.1 uc007hvu.2 uc007hvu.3 uc007hvu.4 This gene encodes a member of the Gas2 family, actin-associated proteins expressed at high levels in growth-arrested cells. The gene expression is negatively regulated by serum and growth factors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]. Seems to be involved in the cross-linking of microtubules and microfilaments (By similarity). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity). Interacts with MAPRE1. Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, stress fiber Note=Colocalizes with the tips of microtubule plus ends. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Beta; IsoId=Q8JZP9-1; Sequence=Displayed; Name=2; Synonyms=Alpha; IsoId=Q8JZP9-2; Sequence=VSP_015496; Belongs to the GAS2 family. microtubule bundle formation cytoplasm cytoskeleton negative regulation of microtubule depolymerization cell cycle arrest microtubule binding cytoskeletal adaptor activity cellular response to starvation negative regulation of gene expression negative regulation of cell growth negative regulation of erythrocyte differentiation thyroid hormone receptor binding regulation of cell cycle cellular response to thyroid hormone stimulus stress fiber microtubule uc007hvu.1 uc007hvu.2 uc007hvu.3 uc007hvu.4 
ENSMUST00000056665.4 Klhl11 ENSMUST00000056665.4 kelch-like 11, transcript variant 1 (from RefSeq NM_172565.2) ENSMUST00000056665.1 ENSMUST00000056665.2 ENSMUST00000056665.3 KLH11_MOUSE NM_172565 Q3TDZ6 Q8CE33 Q91VP6 uc007llj.1 uc007llj.2 uc007llj.3 Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. Homodimer. Interacts with CUL3. Component of a cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CE33-1; Sequence=Displayed; Name=2; IsoId=Q8CE33-2; Sequence=VSP_019496; Sequence=BAE41452.1; Type=Frameshift; Evidence=; uc007llj.1 uc007llj.2 uc007llj.3 
ENSMUST00000056676.5 Mrgprb8 ENSMUST00000056676.5 MAS-related GPR, member B8 (from RefSeq NM_207539.2) B2RR10 ENSMUST00000056676.1 ENSMUST00000056676.2 ENSMUST00000056676.3 ENSMUST00000056676.4 MRGB8_MOUSE Mrgb8 NM_207539 Q7TN51 uc009hao.1 uc009hao.2 uc009hao.3 Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Mas subfamily. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009hao.1 uc009hao.2 uc009hao.3 
ENSMUST00000056677.8 Zfp830 ENSMUST00000056677.8 zinc finger protein 830 (from RefSeq NM_025884.4) Ccdc16 ENSMUST00000056677.1 ENSMUST00000056677.2 ENSMUST00000056677.3 ENSMUST00000056677.4 ENSMUST00000056677.5 ENSMUST00000056677.6 ENSMUST00000056677.7 NM_025884 Omcg1 Q3TR52 Q8R1N0 Q9CWV9 Q9CYI6 ZN830_MOUSE Zfp830 Znf830 uc007kmy.1 uc007kmy.2 uc007kmy.3 May play a role in pre-mRNA splicing as component of the spliceosome (By similarity). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity (PubMed:21191184, PubMed:23213458, PubMed:25168238, PubMed:15988037). During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation (PubMed:21191184). Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells (PubMed:23213458). During the embryo preimplantation, controls different aspects of M phase (PubMed:15988037). During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (PubMed:25168238). Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE; this complex binds preferentially to RNA. Interacts with XAB2. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19. Nucleus Chromosome Nucleus speckle Note=Excluded from nucleolus. In metaphase II oocytes and in mitotic blastomeres, it is detected in cytoplasm, suggesting that it is not associated with chromosomes during mitosis. Widely expressed at low level. Expressed in oocytes from primordial to antral follicles. Also detected in somatic cells of the ovary, namely, in granulosa cells from the pre-antral follicle stage onward (PubMed:25168238). Expressed in preimplantation embryos. Phosphorylated in response to DNA damage by the cell cycle checkpoint kinases ATR/ATM. Mice die by the end of preimplantation development and exhibit a dramatic reduction in the total cell number, a high mitotic index, and the presence of abnormal mitotic figures. Mice appear unwell with significant loss of body weight and rapidly decline afterwards and die. Mice reveal major alterations of their digestive tract including a distended and filled stomach and an intestine lacking spontaneous peristaltism. The small intestine exhibits a thinner wall, less abundant and stunted villi and highly disorganized crypts. Large portion of the gut are almost devoid of normal epithelial structure (PubMed:23213458). Conditional inactivation of Omcg1 in oocytes leads to sterility and early folliculogenesis arrest (PubMed:25168238). mitotic cell cycle ovarian follicle development preantral ovarian follicle growth blastocyst growth molecular_function nucleic acid binding nucleus spliceosomal complex chromosome mRNA processing cell cycle multicellular organism development zinc ion binding RNA splicing nuclear speck nuclear DNA replication mitotic DNA replication checkpoint negative regulation of apoptotic process mitotic DNA damage checkpoint metal ion binding replication fork protection chromosome organization cell division intestinal epithelial structure maintenance uc007kmy.1 uc007kmy.2 uc007kmy.3 
ENSMUST00000056708.4 Kcnv2 ENSMUST00000056708.4 potassium channel, subfamily V, member 2 (from RefSeq NM_183179.1) ENSMUST00000056708.1 ENSMUST00000056708.2 ENSMUST00000056708.3 KCNV2_MOUSE NM_183179 Q8CFS6 uc008hbw.1 uc008hbw.2 uc008hbw.3 Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (By similarity). Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers (By similarity). Cell membrane ; Multi-pass membrane protein The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane regulation of ion transmembrane transport protein homooligomerization transmembrane transport potassium ion transmembrane transport uc008hbw.1 uc008hbw.2 uc008hbw.3 
ENSMUST00000056710.10 Aph1a ENSMUST00000056710.10 aph1 homolog A, gamma secretase subunit, transcript variant 2 (from RefSeq NM_146134.2) APH1A_MOUSE ENSMUST00000056710.1 ENSMUST00000056710.2 ENSMUST00000056710.3 ENSMUST00000056710.4 ENSMUST00000056710.5 ENSMUST00000056710.6 ENSMUST00000056710.7 ENSMUST00000056710.8 ENSMUST00000056710.9 NM_146134 Q8BVF7 Q8R1T3 Q91VL5 uc008qlq.1 uc008qlq.2 uc008qlq.3 uc008qlq.4 This gene encodes a subunit of the gamma-secretase complex, which is localized to the endoplasmic reticulum and golgi apparatus. Gamma-secretase is a multi-protein enzyme that catalyzes intramembraneous proteolysis of type I transmembrane proteins and is essential for many signaling pathways, including the Notch signaling pathway. Studies suggest that the protein encoded by this locus binds directly to substrates of the gamma-secretase complex, including the beta-amyloid precursor protein which is associated with Alzheimer disease progression. This gene is required for normal embryonic development and survival, and disruption is associated with defects in the yolk sack angiogenesis, neural tube formation, and somitogenesis. A pseudogene of this gene is located on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:15634781, PubMed:19369254). Required for normal gamma-secretase assembly (PubMed:15634781, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BVF7-1; Sequence=Displayed; Name=2; IsoId=Q8BVF7-2; Sequence=VSP_008357, VSP_008358; Full embryonic lethality. No live homozygous embryos are present after 11 dpc. Belongs to the APH-1 family. metanephros development endopeptidase activity protein binding mitochondrion early endosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane integral component of plasma membrane membrane protein ectodomain proteolysis Notch signaling pathway Notch receptor processing synaptic vesicle peptidase activity membrane integral component of membrane protein processing membrane protein intracellular domain proteolysis Golgi cisterna membrane beta-amyloid formation amyloid precursor protein metabolic process amyloid precursor protein catabolic process positive regulation of catalytic activity gamma-secretase complex synaptic membrane integral component of presynaptic membrane uc008qlq.1 uc008qlq.2 uc008qlq.3 uc008qlq.4 
ENSMUST00000056711.3 4933427E11Rik ENSMUST00000056711.3 4933427E11Rik (from geneSymbol) AK006196 ENSMUST00000056711.1 ENSMUST00000056711.2 uc007wfq.1 uc007wfq.2 uc007wfq.3 uc007wfq.4 uc007wfq.5 uc007wfq.1 uc007wfq.2 uc007wfq.3 uc007wfq.4 uc007wfq.5 
ENSMUST00000056712.4 Pcdhb4 ENSMUST00000056712.4 protocadherin beta 4 (from RefSeq NM_053129.3) ENSMUST00000056712.1 ENSMUST00000056712.2 ENSMUST00000056712.3 NM_053129 Pcdhb4 Q91XZ6 Q91XZ6_MOUSE uc008epp.1 uc008epp.2 uc008epp.3 molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epp.1 uc008epp.2 uc008epp.3 
ENSMUST00000056728.5 Saxo2 ENSMUST00000056728.5 stabilizer of axonemal microtubules 2, transcript variant 2 (from RefSeq NM_177894.5) ENSMUST00000056728.1 ENSMUST00000056728.2 ENSMUST00000056728.3 ENSMUST00000056728.4 Fam154b G3X9C9 NM_177894 Q8BQB6 SAXO2_MOUSE uc009idb.1 uc009idb.2 uc009idb.3 Belongs to the FAM154 family. nucleus centriole cytoskeleton axonemal microtubule microtubule binding motile cilium microtubule anchoring ciliary basal body sperm flagellum uc009idb.1 uc009idb.2 uc009idb.3 
ENSMUST00000056732.4 Mfap1b ENSMUST00000056732.4 microfibrillar-associated protein 1B (from RefSeq NM_001081975.3) C0HKD9 ENSMUST00000056732.1 ENSMUST00000056732.2 ENSMUST00000056732.3 MFA1B_MOUSE Mfap1b NM_001081975 Q3TU29 Q8CCL1 Q9CQU1 Q9CSJ5 uc008lzg.1 uc008lzg.2 uc008lzg.3 Involved in pre-mRNA splicing as a component of the spliceosome. Component of the spliceosome B complex. Interacts with PRPF38A (via N-terminal interaction domain). Nucleus Belongs to the MFAP1 family. mRNA splicing, via spliceosome microfibril extracellular matrix structural constituent nucleus spliceosomal complex mRNA processing biological_process RNA splicing U2-type precatalytic spliceosome uc008lzg.1 uc008lzg.2 uc008lzg.3 
ENSMUST00000056740.6 Gldn ENSMUST00000056740.6 gliomedin (from RefSeq NM_177350.5) Crgl2 ENSMUST00000056740.1 ENSMUST00000056740.2 ENSMUST00000056740.3 ENSMUST00000056740.4 ENSMUST00000056740.5 GLDN_MOUSE NM_177350 Q80ZC5 Q8BMF8 uc009pqx.1 uc009pqx.2 uc009pqx.3 Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC (PubMed:20188654). Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters (PubMed:20188654). Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier (PubMed:24719088). Homotrimer (via collagen-like domains) (PubMed:17293346). Interacts with NRCAM and NFASC/neurofascin (PubMed:16039564, PubMed:20188654). Interaction with glial NRCAM enhances interaction with axonal NFASC (PubMed:20188654). Interacts with MYOC (PubMed:23897819). Cell membrane ; Single-pass type II membrane protein Cell projection, axon te=Localizes to the nodes of Ranvier (PubMed:17293346, PubMed:20188654). Detected at immature heminodes (By similarity). [Gliomedin shedded ectodomain]: Secreted Secreted, extracellular space, extracellular matrix Note=Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:17293346). The gliomedin shedded ectodomain localizes to the nodes of Ranvier (By similarity). Detected in sciatic nerve (at protein level) (PubMed:17293346, PubMed:20188654, PubMed:24719088). Widely expressed with higher expression in testis and skeletal muscle (PubMed:12642876). The olfactomedin-like domain mediates NFASC/neurofascin and NRCAM binding. N-glycosylated. Proteolytic proccessing by a furin-like protease causes shedding of the ectodomain. Further cleavage by BMP1 releases the olfactomedin- like domain. Mutant mice present no obvious neurological phenotype and have normal nerve conduction. Nerves from their peripheral nervous system have myelin sheets that are indistinguishable from wild-type. In contrast, they present impaired and disorganized attachment of Schwann cell microvilli to the axolemma at nodes of Ranvier. Mature nodes are formed by the fusion of two heminodes. During development, mutant mice present defective clustering of sodium channels at heminodes, but display normal sodium channel clustering at mature nodes (PubMed:20188654). Mice lacking both Gldn and Nrcam are born at the expected Mendelian rate, but are smaller than control littermates and display important neurological impairments, in spite of seemingly normal nerve myelination. Motor abnormalities vary between individuals, ranging from ataxia, uncoordinated movements and premature death to weakness of the hind limbs, hypomotility, strongly impaired ability to hang from a horizontal bar with their forelimbs and a tendency to stumble. The motor defects correlate with decreased velocity of nerve conduction and slower propagation of action potentials. Most mice die within 60 days after birth, and none are fertile. Mutant mice display delayed formation of mature nodes of Ranvier; 15 days after birth about 20% of the nodes lack detectable sodium channel clusters. Sodium channel clustering and nerve conduction appear normal 60 and 75 days after birth, but subsequently a gradual disintegration of the nodal protein complexes is seen. About 70% of the mutant nodes present high-density sodium channel clustering at 120 days after birth, as opposed to nearly 100% for wild-type. Contrary to wild- type, in adult nodes of Ranvier the sodium channels are often clustered near the paranode border with an empty gap in the middle. At nodes of Ranvier, Schwann cell microvilli are sparse or absent and show defects in their orientation, resulting in various structural abnormalities at the node and the paranode border (PubMed:24719088). Sequence=AAO49510.1; Type=Erroneous initiation; Evidence=; protein binding extracellular region collagen trimer extracellular space plasma membrane multicellular organism development nervous system development cell surface membrane integral component of membrane cell differentiation axon microvillus organization heterotypic cell-cell adhesion cell projection clustering of voltage-gated sodium channels protein binding involved in heterotypic cell-cell adhesion uc009pqx.1 uc009pqx.2 uc009pqx.3 
ENSMUST00000056749.14 Nhlrc3 ENSMUST00000056749.14 NHL repeat containing 3 (from RefSeq NM_172501.2) ENSMUST00000056749.1 ENSMUST00000056749.10 ENSMUST00000056749.11 ENSMUST00000056749.12 ENSMUST00000056749.13 ENSMUST00000056749.2 ENSMUST00000056749.3 ENSMUST00000056749.4 ENSMUST00000056749.5 ENSMUST00000056749.6 ENSMUST00000056749.7 ENSMUST00000056749.8 ENSMUST00000056749.9 NHLC3_MOUSE NM_172501 Q8CCH2 Q8CDW5 uc008per.1 uc008per.2 uc008per.3 protein polyubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin protein ligase activity uc008per.1 uc008per.2 uc008per.3 
ENSMUST00000056754.4 Cypt3 ENSMUST00000056754.4 cysteine-rich perinuclear theca 3, transcript variant 2 (from RefSeq NM_173367.3) Cypt3 ENSMUST00000056754.1 ENSMUST00000056754.2 ENSMUST00000056754.3 NM_173367 Q80ZR9 Q80ZR9_MOUSE uc009uqx.1 uc009uqx.2 uc009uqx.3 uc009uqx.4 molecular_function cellular_component biological_process uc009uqx.1 uc009uqx.2 uc009uqx.3 uc009uqx.4 
ENSMUST00000056758.9 Ppp3ca ENSMUST00000056758.9 protein phosphatase 3, catalytic subunit, alpha isoform, transcript variant 1 (from RefSeq NM_008913.5) B2RRX2 Calna ENSMUST00000056758.1 ENSMUST00000056758.2 ENSMUST00000056758.3 ENSMUST00000056758.4 ENSMUST00000056758.5 ENSMUST00000056758.6 ENSMUST00000056758.7 ENSMUST00000056758.8 NM_008913 P12816 P20652 P63328 PP2BA_MOUSE Ppp3ca Q3UCU1 Q64135 uc008rmg.1 uc008rmg.2 uc008rmg.3 uc008rmg.4 Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:7791792, PubMed:26794871). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (By similarity). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (By similarity). Dephosphorylates and inactivates transcription factor ELK1 (By similarity). Dephosphorylates DARPP32 (By similarity). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (By similarity). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (PubMed:15509543). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (PubMed:16735444). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (PubMed:21435446). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (PubMed:10200317). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (PubMed:19626032). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (PubMed:16286645). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (PubMed:16968888). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (PubMed:12773574). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (PubMed:26029823). Required for antigen-specific T-cell proliferation response (PubMed:8627154). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (By similarity). Negatively regulates SLC9A1 activity (By similarity). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Name=Fe(3+); Xref=ChEBI:CHEBI:29034; Evidence=; Note=Binds 1 Fe(3+) ion per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Activated by Ca(2+)-bound calmodulin following an increase in intracellular Ca(2+) (PubMed:26794871). At low Ca(2+) concentrations, the catalytic subunit (also known as calcineurin A) is inactive and is bound to the regulatory subunit (also known as calcineurin B) in which only two high-affinity binding sites are occupied by Ca(2+) (PubMed:26794871). In response to elevated calcium levels, the occupancy of the low-affinity sites on calcineurin B by Ca(2+) causes a conformational change of the C-terminal regulatory domain of calcineurin A, resulting in the exposure of the calmodulin- binding domain and in the partial activation of calcineurin A (PubMed:26794871). The subsequent binding of Ca(2+)-bound calmodulin leads to the displacement of the autoinhibitory domain from the active site and possibly of the autoinhibitory segment from the substrate binding site which fully activates calcineurin A (PubMed:26794871). Inhibited by immunosuppressant drug FK506 (tacrolimus) in complex with FKBP12 and also by immunosuppressant drug cyclosporin A (CsA) in complex with PPIA/cyclophilin A; the inhibition is Ca(2+)-dependent (By similarity). Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B) (PubMed:26794871). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). In response to an increase in Ca(2+) intracellular levels, forms a complex composed of PPP3CA/calcineurin A, calcineurin B and calmodulin (By similarity). Interacts (via calcineurin B binding domain) with regulatory subunit PPP3R1/calcineurin B (PubMed:26794871). Interacts (via calmodulin- binding domain) with calmodulin; the interaction depends on calmodulin binding to Ca(2+) (By similarity). Forms a complex composed of MYOZ2 and ACTN1 (PubMed:11114196). Within the complex interacts with MYOZ2 (PubMed:11114196). Interacts with MYOZ1 (PubMed:11114196). Interacts with MYOZ3 (By similarity). Interacts with CIB1; the interaction increases upon cardiomyocyte hypertrophy (PubMed:20639889). Interacts with CHP1 and CHP2 (By similarity). Interacts with CRTC1 (PubMed:30611118). Interacts with CRTC2 (PubMed:30611118). Interacts with DNM1L; the interaction dephosphorylates DNM1L and promotes its translocation to mitochondria (By similarity). Interacts with CMYA5; this interaction represses calcineurin activity in muscle (PubMed:21427212). Interacts (constitutively active form) with SYNPO2 (By similarity). Interacts with scaffold protein AKAP5 (via IAIIIT motif); the interaction recruits PPP3CA to the plasma membrane following L-type Ca(2+)-channel activation (By similarity). Interacts with NFATC2 (By similarity). Interacts with RCAN3 (By similarity). Interacts with PPIA (By similarity). Interacts with RCAN1 (PubMed:12809556). Interacts with UNC119 (PubMed:31696965). Interacts with C16orf74 (via PxIxIT motif, when phosphorylated on 'Thr-79') (By similarity). Interacts (via N-terminus) with MAP3K14/NIK (via C- terminus and kinase domain) (PubMed:26029823). Interacts with TRAF3 (PubMed:26029823). Interacts with SPATA33 (via PQIIIT motif) (By similarity). P63328; Q3U182: Crtc2; NbExp=2; IntAct=EBI-397208, EBI-8018890; Cytoplasm ll membrane ; Peripheral membrane protein Cell membrane, sarcolemma Cytoplasm, myofibril, sarcomere, Z line Cell projection, dendritic spine Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca(2+)-channel activation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P63328-1; Sequence=Displayed; Name=2; IsoId=P63328-2; Sequence=VSP_018563; Expressed in the kidney (at protein level) (PubMed:15509543). Expressed in the salivary gland (at protein level) (PubMed:21435446). Expressed in osteoblasts and bone marrow (at protein level) (PubMed:16286645). Expressed in the brain and the bicep, tricep, soleus and gastrocnemius muscles (at protein level) (PubMed:12773574). Abundantly expressed in the dentate gyrus and the CA1 and CA3 regions of the hippocampus (at protein level) (PubMed:10200317). Expressed in T-lymphocytes (at protein level) (PubMed:8627154). Expressed in embryonic stem cells (PubMed:8627154). The autoinhibitory domain prevents access to the catalytic site. The autoinhibitory segment prevents access to the substrate binding site. Possible isomerization of Pro-309 within the SAPNY motif triggers a conformation switch which affects the organization and thus accessibility of the active site and the substrate binding region (PxIxIF motif). The trans- to cis-transition may favor calcineurin A activation and substrate binding. The reverse cis- to trans-transition may be enhanced by peptidyl-prolyl isomerases such as PPIA. Knockout mice are significantly smaller at postnatal day 18 (P18), including significantly reduced weights of the liver and kidneys (PubMed:15509543, PubMed:16735444). Decreased blood glucose levels (PubMed:16735444). Decreased lumber spine, tibia, and total body bone mass density evident at 6 weeks of age, evidence of decreased density in the lumber spine as early as 3 weeks of age (PubMed:16286645). No change in overall muscle weight (PubMed:12773574). Decreased femur length, reduced cortical trabecular bone thickness (PubMed:16286645). Significantly reduced number of differentiated osteoclasts (PubMed:16968888). Reduced mitochondrial oxidative capacity in slow and intermediate muscle fiber types (PubMed:12773574). Reduced slow and intermediate program type muscle fibers in the biceps and triceps (PubMed:12773574). Decreased number of slow program type muscle fibers and NFAT activity in the soleus (PubMed:12773574). Kidney size and development is normal at P4, however by P18 kidneys show an obvious delay in maturation, displaying a decreased overall mass, poorly defined medullary rays and decreased cortical mass (PubMed:15509543). Upon examination the outer strip of the medulla and cortical regions of the kidneys are significantly decreased (PubMed:15509543). In the cortex there is a persistence of poorly developed surface glomeruli due to attenuation of mesangial cells numbers and a lack of maturation of tubules in the nephrogenic zone (PubMed:15509543). Reduced proliferation and increased apoptosis of cells within the nephrogenic zone at P18, potentially as a result of increased p27 expression (PubMed:15509543). Impaired kidney function evident by increased kidney collagen deposition, serum creatinine levels and decreased urine creatinine concentration from P4 onwards (PubMed:15509543, PubMed:16735444). Loss of AQP2 phosphorylation in response to vasopressin and decreased localization to the apical membrane of inner medullary collecting duct cells (PubMed:16735444). Most mice die between P21 and P28 as a result of progressive kidney failure (PubMed:15509543). Increased salivary osmolality despite normal electrolyte composition and protein content (PubMed:21435446). Decreased activity of amylase, peroxidase, lysozyme and sialic acid in the saliva (PubMed:21435446). Decreased number of secretory vesicles, mucosal acini cell size and protein content of serosal acini in the submandibular glands (PubMed:21435446). Decreased activity of calcineurin in the salivary glands (PubMed:21435446). Decreased thickness of the epidermal stratum spinosum, a thickened corneum and increased sloughing-off of keratinocytes in newborn mice (PubMed:19626032). Decreased thickness of the stratum spinosum is still evident at 4 weeks of age along with decreased skin elasticity (PubMed:19626032). Increased apoptosis in the supra-basal layers and the stratum spinosum of the epidermis (PubMed:19626032). Decrease in NFATc activity in basal epidermal cells and impaired differentiation of epidermal keratinocytes as shown by aberrant expression of the differentiation markers KRT14, KRT10 and IVL (PubMed:19626032). Decreased calcineurin activity in the brain and significant reduction in homosynaptic depotentiation (PubMed:10200317). Decreased calcineurin activity in T-lymphocytes and loss of T-lymphocyte proliferation in response to antigen stimulation (PubMed:8627154). Belongs to the PPP phosphatase family. PP-2B subfamily. G1/S transition of mitotic cell cycle response to amphetamine phosphoprotein phosphatase activity protein serine/threonine phosphatase activity calcium-dependent protein serine/threonine phosphatase activity protein binding calmodulin binding nucleus nucleoplasm cytoplasm mitochondrion cytosol plasma membrane calcineurin complex protein dephosphorylation protein import into nucleus calcium ion transport brain development aging drug binding cytoplasmic side of plasma membrane positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression transition between fast and slow fiber cardiac muscle hypertrophy in response to stress cyclosporin A binding membrane dephosphorylation hydrolase activity calcium-mediated signaling enzyme binding Z disc positive regulation of cell migration calcineurin-NFAT signaling cascade calmodulin-dependent protein phosphatase activity multicellular organismal response to stress negative regulation of chromatin binding cellular response to drug slit diaphragm sarcolemma cell projection dendritic spine synapse positive regulation of cell adhesion positive regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion metal ion binding protein heterodimerization activity protein dimerization activity skeletal muscle fiber development negative regulation of dendrite morphogenesis modulation of synaptic transmission positive regulation of sequence-specific DNA binding transcription factor activity response to calcium ion excitatory postsynaptic potential peptidyl-serine dephosphorylation cellular response to glucose stimulus calcineurin-mediated signaling glutamatergic synapse positive regulation of cardiac muscle hypertrophy in response to stress negative regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of connective tissue replacement uc008rmg.1 uc008rmg.2 uc008rmg.3 uc008rmg.4 
ENSMUST00000056781.5 Ccdc57 ENSMUST00000056781.5 coiled-coil domain containing 57, transcript variant 3 (from RefSeq NR_184673.1) CCD57_MOUSE Ccdc57 ENSMUST00000056781.1 ENSMUST00000056781.2 ENSMUST00000056781.3 ENSMUST00000056781.4 NR_184673 Q6PHN1 uc007muv.1 uc007muv.2 uc007muv.3 Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis (PubMed:32402286). Critical interface between centrosome and microtubule-mediated cellular processes. Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to the centrosome. Independent of its centrosomal targeting, localizes to and interacts with microtubules and regulates microtubule nucleation, stability, and mitotic progression (By similarity). Interacts with CEP63; the interaction is required for their location to proximal end of centrioles. Interacts with microtubules. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle Note=Localizes to resolvable rings at the proximal end of centrioles. In mitotic cells, localizes to spindle microtubules during metaphase. molecular_function cellular_component biological_process uc007muv.1 uc007muv.2 uc007muv.3 
ENSMUST00000056815.9 Npas2 ENSMUST00000056815.9 neuronal PAS domain protein 2 (from RefSeq NM_008719.2) ENSMUST00000056815.1 ENSMUST00000056815.2 ENSMUST00000056815.3 ENSMUST00000056815.4 ENSMUST00000056815.5 ENSMUST00000056815.6 ENSMUST00000056815.7 ENSMUST00000056815.8 G3X9B7 G3X9B7_MOUSE NM_008719 Npas2 uc007atd.1 uc007atd.2 uc007atd.3 uc007atd.4 The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. The encoded protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Dec 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC109166.2, U77969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated positive regulation of DNA repair positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity response to redox state Hsp90 protein binding negative regulation of cell death regulation of response to DNA damage stimulus uc007atd.1 uc007atd.2 uc007atd.3 uc007atd.4 
ENSMUST00000056822.4 Acot6 ENSMUST00000056822.4 acyl-CoA thioesterase 6, transcript variant 1 (from RefSeq NM_172580.2) ACOT6_MOUSE Acot6 ENSMUST00000056822.1 ENSMUST00000056822.2 ENSMUST00000056822.3 NM_172580 Q32Q92 Q3TQG7 Q8BXE0 Q8BYI3 Q99LZ0 uc007oei.1 uc007oei.2 uc007oei.3 Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Catalyzes the hydrolysis of phytanoyl-CoA and pristanoyl-CoA, two methyl-branched fatty acids derived from phytol, that enter the body via the diet. Reaction=H2O + pristanoyl-CoA = 2,6,10,14-tetramethylpentadecanoate + CoA + H(+); Xref=Rhea:RHEA:40415, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:77250, ChEBI:CHEBI:77268; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40416; Evidence=; Reaction=H2O + phytanoyl-CoA = 3,7,11,15-tetramethylhexadecanoate + CoA + H(+); Xref=Rhea:RHEA:40419, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37257, ChEBI:CHEBI:57287, ChEBI:CHEBI:57391; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40420; Evidence=; Kinetic parameters: KM=24 uM for pristanoyl-CoA ; Vmax=3.2 umol/min/mg enzyme with pristanoyl-CoA as substrate ; Lipid metabolism; fatty acid metabolism. Peroxisome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q32Q92-1; Sequence=Displayed; Name=2; IsoId=Q32Q92-2; Sequence=VSP_028234, VSP_028235; Highly expressed in white adipose tissue. Detected at lower levels in kidney, liver, brown adipose tissue and brain. Up-regulated in liver upon treatment with peroxisome proliferator. Belongs to the C/M/P thioester hydrolase family. Sequence=BAC30372.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC33071.1; Type=Frameshift; Evidence=; Sequence=BAE37416.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Small insertion of unknown origin.; Evidence=; peroxisome lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process hydrolase activity thiolester hydrolase activity acyl-CoA hydrolase activity carboxylic ester hydrolase activity uc007oei.1 uc007oei.2 uc007oei.3 
ENSMUST00000056849.3 Or5m5 ENSMUST00000056849.3 olfactory receptor family 5 subfamily M member 5 (from RefSeq NM_146588.2) ENSMUST00000056849.1 ENSMUST00000056849.2 Mor196-2 NM_146588 OR5M5_MOUSE Olfr1030 Or5m5 Q8VFL5 uc008klh.1 uc008klh.2 uc008klh.3 uc008klh.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB174013.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Sequence=AAP71477.1; Type=Erroneous initiation; Evidence=; G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008klh.1 uc008klh.2 uc008klh.3 uc008klh.4 
ENSMUST00000056866.8 Pnpla1 ENSMUST00000056866.8 patatin-like phospholipase domain containing 1 (from RefSeq NM_001034885.3) ENSMUST00000056866.1 ENSMUST00000056866.2 ENSMUST00000056866.3 ENSMUST00000056866.4 ENSMUST00000056866.5 ENSMUST00000056866.6 ENSMUST00000056866.7 NM_001034885 PLPL1_MOUSE Pnpla1 Q3V1D5 uc008brt.1 uc008brt.2 uc008brt.3 Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation (PubMed:27751867, PubMed:28248300). Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide (PubMed:27751867, PubMed:28248300). Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function (PubMed:27751867, PubMed:28248300). These lipids also play a role in keratinocyte differentiation (PubMed:28248300). May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS) (PubMed:28248300). Reaction=a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base = a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base; Xref=Rhea:RHEA:61528, ChEBI:CHEBI:18035, ChEBI:CHEBI:144774, ChEBI:CHEBI:144784, ChEBI:CHEBI:144785; EC=2.3.1.296; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61529; Evidence=; Reaction=a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine = a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine; Xref=Rhea:RHEA:65692, ChEBI:CHEBI:18035, ChEBI:CHEBI:144774, ChEBI:CHEBI:157662, ChEBI:CHEBI:157663; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65693; Evidence=; Reaction=a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N- (28-hydroxyoctacosanoyl)-sphing-4-enine = a diacylglycerol + N-(28- (9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine; Xref=Rhea:RHEA:65648, ChEBI:CHEBI:18035, ChEBI:CHEBI:144774, ChEBI:CHEBI:157643, ChEBI:CHEBI:157652; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65649; Evidence=; Reaction=1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30- hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)- octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)- triacontanoyl]-sphing-4-enine; Xref=Rhea:RHEA:55264, ChEBI:CHEBI:34862, ChEBI:CHEBI:75844, ChEBI:CHEBI:138658, ChEBI:CHEBI:138664; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55265; Evidence=; Reaction=a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N- (32-hydroxydotriacontanoyl)-sphing-4-enine = a diacylglycerol + N- (32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine; Xref=Rhea:RHEA:65652, ChEBI:CHEBI:18035, ChEBI:CHEBI:144774, ChEBI:CHEBI:157644, ChEBI:CHEBI:157653; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65653; Evidence=; Reaction=a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N- (32-hydroxydotriacontenoyl)-sphing-4-enine = a diacylglycerol + an N- (32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine; Xref=Rhea:RHEA:65668, ChEBI:CHEBI:18035, ChEBI:CHEBI:144774, ChEBI:CHEBI:157645, ChEBI:CHEBI:157657; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65669; Evidence=; Reaction=a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4- enine; Xref=Rhea:RHEA:65672, ChEBI:CHEBI:18035, ChEBI:CHEBI:144774, ChEBI:CHEBI:157646, ChEBI:CHEBI:157656; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65673; Evidence=; Reaction=a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine = a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing- 4-enine; Xref=Rhea:RHEA:65676, ChEBI:CHEBI:18035, ChEBI:CHEBI:144774, ChEBI:CHEBI:157647, ChEBI:CHEBI:157658; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65677; Evidence=; Reaction=a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4- enine; Xref=Rhea:RHEA:65680, ChEBI:CHEBI:18035, ChEBI:CHEBI:144774, ChEBI:CHEBI:157648, ChEBI:CHEBI:157659; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65681; Evidence=; Reaction=a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine = a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing- 4-enine; Xref=Rhea:RHEA:65684, ChEBI:CHEBI:18035, ChEBI:CHEBI:144774, ChEBI:CHEBI:157649, ChEBI:CHEBI:157660; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65685; Evidence=; Reaction=a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4- enine; Xref=Rhea:RHEA:65688, ChEBI:CHEBI:18035, ChEBI:CHEBI:144774, ChEBI:CHEBI:157650, ChEBI:CHEBI:157661; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65689; Evidence=; Cytoplasm Specifically expressed in skin by keratinocytes, at the boundary area between the nucleated stratum granulosum and the denucleated stratum corneum in the epidermis (at protein level) (PubMed:28248300). Also expressed in stomach and other surface lining tissues like intestine and tongue (PubMed:27751867, PubMed:28248300). Also detected in testis as well as in other tissues but at very low level (PubMed:28248300). Up-regulated upon induced differentiation of keratinocytes. Homozygous knockout mice lacking Pnpla1 are obtained at the expected Mendelian ratio but die within 24 hours after birth (PubMed:27751867, PubMed:28248300). They display shiny and taut skin, often with a necrotic tail tip (PubMed:27751867, PubMed:28248300). They are less active, markedly smaller, and weighed significantly less than their wild-type counterpart (PubMed:27751867). Unique linoleate-containing lipids including acylceramides, acylglucosylceramides and (O-acyl)-omega-hydroxy fatty acids are almost absent in the epidermis while there is a reciprocal increase in their putative precursors (PubMed:27751867, PubMed:28248300). The absence of these highly hydrophobic linoleate-containing lipids in the epidermis is responsible for the lethal disruption of the epidermal permeability barrier which is characterized by a decrease in intercellular lipid lamellae in the stratum corneum, the loss or abnormalities of the cornified lipid envelope, and aberrant keratinocyte differentiation (PubMed:27751867, PubMed:28248300). Keratinocyte-specific conditional knockout mice also die shortly after birth, displaying desquamation with alteration of the stratum corneum and of the lipid composition of the epidermis (PubMed:28248300). triglyceride lipase activity cytoplasm lipid particle lipid metabolic process membrane lipid catabolic process hydrolase activity triglyceride catabolic process lipid homeostasis uc008brt.1 uc008brt.2 uc008brt.3 
ENSMUST00000056882.7 Olig1 ENSMUST00000056882.7 oligodendrocyte transcription factor 1 (from RefSeq NM_016968.4) ENSMUST00000056882.1 ENSMUST00000056882.2 ENSMUST00000056882.3 ENSMUST00000056882.4 ENSMUST00000056882.5 ENSMUST00000056882.6 NM_016968 OLIG1_MOUSE Q9JKN5 uc007zxf.1 uc007zxf.2 uc007zxf.3 Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube. Q9JKN5; P41136: Id2; NbExp=5; IntAct=EBI-1213712, EBI-309167; Q9JKN5; P41139: Id4; NbExp=5; IntAct=EBI-1213712, EBI-1213725; Nucleus Expressed specifically in brain. Expressed in the ventral spinal cord as early as 9.5 dpc. Expression declines to undetectable levels by 10.5 dpc and reappears in a narrow zone within the ventral neuroepithelium of the spinal cord. In the 14.5 dpc spinal cord, expressed in the oligodendrocyte progenitors of the ventral ventricular zone, but not dorsal root ganglia Schwann cells. Also expressed scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. By 15.5 dpc, dispersed throughout the gray matter, with little or no residual expression in the ventricular zone. In the postnatal brain, present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Expressed in the olfactory epithelium from 11.5dpc onward. By SHH. Sequence=BAB18906.1; Type=Erroneous initiation; Evidence=; DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated multicellular organism development protein dimerization activity neuron fate commitment oligodendrocyte differentiation uc007zxf.1 uc007zxf.2 uc007zxf.3 
ENSMUST00000056888.13 Ankrd13d ENSMUST00000056888.13 ankyrin repeat domain 13 family, member D (from RefSeq NM_026720.2) AN13D_MOUSE ENSMUST00000056888.1 ENSMUST00000056888.10 ENSMUST00000056888.11 ENSMUST00000056888.12 ENSMUST00000056888.2 ENSMUST00000056888.3 ENSMUST00000056888.4 ENSMUST00000056888.5 ENSMUST00000056888.6 ENSMUST00000056888.7 ENSMUST00000056888.8 ENSMUST00000056888.9 G3X9A8 NM_026720 Q6PD24 uc008fzr.1 uc008fzr.2 uc008fzr.3 Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). Interacts with EGFR (ubiquitinated); the interaction is direct and may regulate EGFR internalization. Cell membrane. Late endosome. Note=Interaction with EGFR may enhance association with the cell membrane. Sequence=AAH58982.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of receptor internalization cytoplasm endosome late endosome plasma membrane membrane perinuclear region of cytoplasm uc008fzr.1 uc008fzr.2 uc008fzr.3 
ENSMUST00000056889.15 Chd4 ENSMUST00000056889.15 chromodomain helicase DNA binding protein 4, transcript variant 8 (from RefSeq NM_001403598.1) CHD4_MOUSE ENSMUST00000056889.1 ENSMUST00000056889.10 ENSMUST00000056889.11 ENSMUST00000056889.12 ENSMUST00000056889.13 ENSMUST00000056889.14 ENSMUST00000056889.2 ENSMUST00000056889.3 ENSMUST00000056889.4 ENSMUST00000056889.5 ENSMUST00000056889.6 ENSMUST00000056889.7 ENSMUST00000056889.8 ENSMUST00000056889.9 NM_001403598 Q6PDQ2 uc009dtk.1 uc009dtk.2 uc009dtk.3 uc009dtk.4 ATP-dependent helicase that binds and distorts nucleosomal DNA (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:17938210). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (By similarity). Involved in neurogenesis (PubMed:27806305). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:27806305). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:27806305). Interacts with IKFZ1; the interaction is direct and when in part of the NuRD complex (PubMed:11003653). Part of a complex containing ATR and HDAC2 (By similarity). Interacts with HDAC2; the interaction is direct (PubMed:27806305). Interacts with the cohesin complex component RAD21; the interaction is direct (By similarity). Interacts with the ISWI chromatin remodeling complex component SMARCA5; the interaction is direct (By similarity). Interacts with ZGPAT; the interaction is direct (By similarity). Interacts with ZMYND8; the interaction is direct, appears to occur with monomeric ZMYND8, and is increased following DNA damage (By similarity). Interacts with BCL6 (By similarity). Interacts with BRD4 (By similarity). Interacts with CBX1 (By similarity). Interacts with CBX3 (By similarity). Interacts with CBX5 (By similarity). Interacts with GATAD2A (By similarity). Interacts with HDAC1 (By similarity). Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression (PubMed:17938210). Interacts with MTA1 (By similarity). Interacts with PCNT (By similarity). Interacts with RBBP7 (By similarity). Interacts with SETX (By similarity). Interacts with TRIM27 (By similarity). Interacts with histone H3 (By similarity). Interacts with histone H4 (By similarity). Does not interact with PWWP2A (PubMed:30228260, PubMed:30327463). Does not interact with PWWP2B (PubMed:30228260). Q6PDQ2; Q60I23: Sox2; NbExp=3; IntAct=EBI-3043852, EBI-6120118; Q6PDQ2; P70326: Tbx5; NbExp=3; IntAct=EBI-3043852, EBI-8411807; Q6PDQ2; Q80V81: Zfp819; NbExp=4; IntAct=EBI-3043852, EBI-6394055; Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Associates with centrosomes in interphase. Localizes to sites of DNA damage in a manner dependent on ZMYND8 and ZNF687. Expression is constant from 12.5 dpc to 18.5 dpc in the cortex. Belongs to the SNF2/RAD54 helicase family. negative regulation of transcription from RNA polymerase II promoter nucleotide binding RNA polymerase II repressing transcription factor binding DNA binding DNA helicase activity helicase activity protein binding ATP binding nucleus nucleoplasm cytoplasm centrosome microtubule organizing center cytoskeleton chromatin organization transcription factor binding NuRD complex hydrolase activity DNA duplex unwinding macromolecular complex protein-DNA complex histone deacetylase binding metal ion binding terminal button organization uc009dtk.1 uc009dtk.2 uc009dtk.3 uc009dtk.4 
ENSMUST00000056890.10 Fbxl22 ENSMUST00000056890.10 F-box and leucine-rich repeat protein 22 (from RefSeq NM_175206.4) ENSMUST00000056890.1 ENSMUST00000056890.2 ENSMUST00000056890.3 ENSMUST00000056890.4 ENSMUST00000056890.5 ENSMUST00000056890.6 ENSMUST00000056890.7 ENSMUST00000056890.8 ENSMUST00000056890.9 FXL22_MOUSE NM_175206 Q8C3G3 Q8C3V6 Q8C7B6 uc009qex.1 uc009qex.2 uc009qex.3 uc009qex.4 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC) (By similarity). Protein modification; protein ubiquitination. Directly interacts with SKP1 and CUL1. Cytoplasm, myofibril, sarcomere, Z line Enriched in cardiac muscle (at protein level). G2/M transition of mitotic cell cycle nucleus cytoplasm cytosol protein ubiquitination SCF ubiquitin ligase complex Z disc SCF-dependent proteasomal ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of cell cycle ubiquitin protein ligase activity uc009qex.1 uc009qex.2 uc009qex.3 uc009qex.4 
ENSMUST00000056904.3 Ercc6l ENSMUST00000056904.3 excision repair cross-complementing rodent repair deficiency complementation group 6 like (from RefSeq NM_146235.3) ENSMUST00000056904.1 ENSMUST00000056904.2 ERC6L_MOUSE NM_146235 Q8BGN1 Q8BHK9 Q8BRC9 Q8CE49 uc009tyk.1 uc009tyk.2 uc009tyk.3 uc009tyk.4 DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Interacts with PLK1, which phosphorylates it. Both proteins are mutually dependent on each other for correct subcellular localization. Interacts (via N-terminal TPR repeat) with BEND3 (via BEN domains 1 and 3); the interaction is direct. Chromosome, centromere Chromosome, centromere, kinetochore Chromosome Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset. Expressed mainly in the neural tube and heart of 10.5 dpc embryo. Significantly down-regulated after alcohol exposure in embryonic brain and heart, but not in embryonic kidney, liver, or lung. Phosphorylation by PLK1 prevents the association with chromosome arms and restricts its localization to the kinetochore-centromere region. Belongs to the SNF2/RAD54 helicase family. nucleotide binding chromosome, centromeric region kinetochore condensed chromosome kinetochore DNA binding DNA helicase activity helicase activity ATP binding chromosome cell cycle DNA translocase activity hydrolase activity DNA duplex unwinding cell division uc009tyk.1 uc009tyk.2 uc009tyk.3 uc009tyk.4 
ENSMUST00000056907.7 Smcr8 ENSMUST00000056907.7 Smith-Magenis syndrome chromosome region, candidate 8 homolog (human), transcript variant 1 (from RefSeq NM_001085440.1) ENSMUST00000056907.1 ENSMUST00000056907.2 ENSMUST00000056907.3 ENSMUST00000056907.4 ENSMUST00000056907.5 ENSMUST00000056907.6 NM_001085440 Q3UMB5 Q5U4H2 Q8BNG6 Q8C704 SMCR8_MOUSE uc007jgn.1 uc007jgn.2 Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27617292). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (By similarity). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (By similarity). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (By similarity). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (By similarity). Component of the C9orf72-SMCR8 complex, at least composed of C9orf72, SMCR8 and WDR41 (Probable). The complex is formed of two protomers, each individually consisting of one molecule each of C9orf72, SMCR8 and WDR41 (By similarity). The protomers homodimerize via an interaction between C9orf72 (via C-terminus) and SMCR8 (via N- terminus) (By similarity). Within each protomer SMCR8 (via DENN domain) acts as a bridging protein between WDR41 (via C-terminus and N- terminus) and C9orf72 (via C-terminus) (By similarity). The C9orf72- SMCR8 complex associates with the ULK1/ATG1 kinase complex (By similarity). Interacts with C9orf72; the interaction is direct (PubMed:27875531). Interacts with DLG4/PSD-95 (PubMed:31651360). Cytoplasm Nucleus Presynapse Postsynapse Note=Localizes mainly in the cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UMB5-1; Sequence=Displayed; Name=2; IsoId=Q3UMB5-2; Sequence=VSP_025488; Widely expressed (PubMed:11997338). Expressed in the forebrain and hippocampus (at protein level) (PubMed:31651360). Phosphorylation by TBK1 is required to promote autophagosome maturation. Phosphorylated by ULK1. Cells lacking display impaired autophagy induction. Belongs to the SMCR8 family. chromatin protein kinase inhibitor activity guanyl-nucleotide exchange factor activity protein binding nucleus nucleoplasm cytoplasm negative regulation of protein kinase activity autophagy regulation of autophagy negative regulation of gene expression negative regulation of macroautophagy Rab guanyl-nucleotide exchange factor activity protein kinase binding positive regulation of TOR signaling guanyl-nucleotide exchange factor complex positive regulation of autophagosome maturation negative regulation of autophagosome assembly regulation of TORC1 signaling ATG1/ULK1 kinase complex uc007jgn.1 uc007jgn.2 
ENSMUST00000056914.7 Bend7 ENSMUST00000056914.7 BEN domain containing 7, transcript variant 1 (from RefSeq NM_178663.4) BEND7_MOUSE ENSMUST00000056914.1 ENSMUST00000056914.2 ENSMUST00000056914.3 ENSMUST00000056914.4 ENSMUST00000056914.5 ENSMUST00000056914.6 NM_178663 Q4VAD9 Q6PHN3 Q8BPJ4 Q8BSV3 Q8C973 uc008iez.1 uc008iez.2 uc008iez.3 uc008iez.4 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BSV3-1; Sequence=Displayed; Name=2; IsoId=Q8BSV3-2; Sequence=VSP_019509; Name=3; IsoId=Q8BSV3-3; Sequence=VSP_019510; Sequence=AAH56476.1; Type=Frameshift; Evidence=; molecular_function biological_process uc008iez.1 uc008iez.2 uc008iez.3 uc008iez.4 
ENSMUST00000056915.3 Pcdhb13 ENSMUST00000056915.3 protocadherin beta 13 (from RefSeq NM_053138.2) ENSMUST00000056915.1 ENSMUST00000056915.2 NM_053138 Pcdhb13 Q91Y06 Q91Y06_MOUSE uc008epy.1 uc008epy.2 uc008epy.3 calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epy.1 uc008epy.2 uc008epy.3 
ENSMUST00000056919.9 Csnk2a2 ENSMUST00000056919.9 casein kinase 2, alpha prime polypeptide (from RefSeq NM_009974.3) Csnk2a2 ENSMUST00000056919.1 ENSMUST00000056919.2 ENSMUST00000056919.3 ENSMUST00000056919.4 ENSMUST00000056919.5 ENSMUST00000056919.6 ENSMUST00000056919.7 ENSMUST00000056919.8 NM_009974 Q545V8 Q545V8_MOUSE uc009myk.1 uc009myk.2 uc009myk.3 uc009myk.4 Belongs to the protein kinase superfamily. nucleotide binding chromatin acrosomal vesicle protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm plasma membrane protein phosphorylation spermatogenesis peptidyl-serine phosphorylation cerebral cortex development PcG protein complex protein N-terminus binding liver regeneration negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc009myk.1 uc009myk.2 uc009myk.3 uc009myk.4 
ENSMUST00000056924.14 Plagl2 ENSMUST00000056924.14 pleiomorphic adenoma gene-like 2 (from RefSeq NM_018807.5) ENSMUST00000056924.1 ENSMUST00000056924.10 ENSMUST00000056924.11 ENSMUST00000056924.12 ENSMUST00000056924.13 ENSMUST00000056924.2 ENSMUST00000056924.3 ENSMUST00000056924.4 ENSMUST00000056924.5 ENSMUST00000056924.6 ENSMUST00000056924.7 ENSMUST00000056924.8 ENSMUST00000056924.9 NM_018807 Plagl2 Q925T4 Q925T4_MOUSE plagl2 uc008nhk.1 uc008nhk.2 uc008nhk.3 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding nucleus transcription, DNA-templated lipid metabolic process post-embryonic development chylomicron assembly sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter positive regulation of intrinsic apoptotic signaling pathway uc008nhk.1 uc008nhk.2 uc008nhk.3 
ENSMUST00000056932.9 Brd8dc ENSMUST00000056932.9 BRD8 domain containing, transcript variant 7 (from RefSeq NR_152401.1) 4933408B17Rik Brd8dc ENSMUST00000056932.1 ENSMUST00000056932.2 ENSMUST00000056932.3 ENSMUST00000056932.4 ENSMUST00000056932.5 ENSMUST00000056932.6 ENSMUST00000056932.7 ENSMUST00000056932.8 G3X9B4 G3X9B4_MOUSE NR_152401 uc008eku.1 uc008eku.2 molecular_function cellular_component biological_process uc008eku.1 uc008eku.2 
ENSMUST00000056937.12 Hscb ENSMUST00000056937.12 HscB iron-sulfur cluster co-chaperone, transcript variant 3 (from RefSeq NR_153348.2) A0A0R4J0T0 A0A0R4J0T0_MOUSE ENSMUST00000056937.1 ENSMUST00000056937.10 ENSMUST00000056937.11 ENSMUST00000056937.2 ENSMUST00000056937.3 ENSMUST00000056937.4 ENSMUST00000056937.5 ENSMUST00000056937.6 ENSMUST00000056937.7 ENSMUST00000056937.8 ENSMUST00000056937.9 Hscb NR_153348 uc008yrv.1 uc008yrv.2 uc008yrv.3 Belongs to the HscB family. ATPase activator activity nucleus cytoplasm mitochondrion cytosol iron-sulfur cluster assembly positive regulation of ATPase activity identical protein binding chaperone binding protein oligomerization protein maturation by iron-sulfur cluster transfer uc008yrv.1 uc008yrv.2 uc008yrv.3 
ENSMUST00000056941.3 Spem2 ENSMUST00000056941.3 SPEM family member 2 (from RefSeq NM_175368.2) ENSMUST00000056941.1 ENSMUST00000056941.2 NM_175368 Q8C5U4 SPEM2_MOUSE Spem2 uc007jru.1 uc007jru.2 uc007jru.3 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007jru.1 uc007jru.2 uc007jru.3 
ENSMUST00000056946.8 Neurl3 ENSMUST00000056946.8 neuralized E3 ubiquitin protein ligase 3 (from RefSeq NM_153408.2) ENSMUST00000056946.1 ENSMUST00000056946.2 ENSMUST00000056946.3 ENSMUST00000056946.4 ENSMUST00000056946.5 ENSMUST00000056946.6 ENSMUST00000056946.7 Lincr NEUL3_MOUSE NM_153408 Q8BS05 Q8CJC5 uc007aps.1 uc007aps.2 uc007aps.3 E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:15936721, PubMed:35792897). Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 (PubMed:35792897). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CJC5-1; Sequence=Displayed; Name=2; IsoId=Q8CJC5-2; Sequence=VSP_032400, VSP_032401; Expressed in alveolar epithelial type II cells. Induced in lung during endotoxemia. By LPS and inflammatory cytokines in alveolar epithelial type II cells. Mutant mice produce less type I IFNs and exhibit increased susceptibility to viral infection. Sequence=BAC30757.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; early endosome protein ubiquitination transferase activity metal ion binding ubiquitin protein ligase activity ubiquitin-dependent endocytosis uc007aps.1 uc007aps.2 uc007aps.3 
ENSMUST00000056949.5 Spesp1 ENSMUST00000056949.5 sperm equatorial segment protein 1 (from RefSeq NM_025721.2) ENSMUST00000056949.1 ENSMUST00000056949.2 ENSMUST00000056949.3 ENSMUST00000056949.4 NM_025721 Q9D5A0 Q9D5X8 SPESP_MOUSE Spesp1 uc009qag.1 uc009qag.2 uc009qag.3 Involved in fertilization ability of sperm. Cytoplasmic vesicle, secretory vesicle, acrosome Note=Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase) (By similarity). After acrosome reaction localizes to the equatorial segment region in both noncapacitated and capacitated, acrosome-reacted sperm (PubMed:25761597). Testis specific. Glycosylated. In testis there are two predominant forms of 77- and 67-kDa and a form of 47-kDa, whereas in epididymal sperm from caput, corpus, and cauda there are two forms of 47- and 43-kDa. Testis forms contain complex carbohydrate residues. Epididymal sperm forms are N- glycosylated. Then undergoes significant glycosylation in the testis and that the majority of these glycoconjugates are removed by the time sperm reach the caput epididymis. Knockout female mice are fertile, while the average number of pups that are fathered by knockout males is significantly lower than that of wild-type fathers. Belongs to the SPESP1 family. acrosomal vesicle protein binding multicellular organism development acrosome reaction fusion of sperm to egg plasma membrane fertilization cytoplasmic vesicle sperm-egg recognition uc009qag.1 uc009qag.2 uc009qag.3 
ENSMUST00000056950.14 Rin3 ENSMUST00000056950.14 Ras and Rab interactor 3, transcript variant 1 (from RefSeq NM_177620.4) B2RQF8 ENSMUST00000056950.1 ENSMUST00000056950.10 ENSMUST00000056950.11 ENSMUST00000056950.12 ENSMUST00000056950.13 ENSMUST00000056950.2 ENSMUST00000056950.3 ENSMUST00000056950.4 ENSMUST00000056950.5 ENSMUST00000056950.6 ENSMUST00000056950.7 ENSMUST00000056950.8 ENSMUST00000056950.9 NM_177620 P59729 RIN3_MOUSE uc007ouc.1 uc007ouc.2 uc007ouc.3 uc007ouc.4 Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function (By similarity). Interacts with CD2AP, RAB5B, RAB31 and BIN1. Cytoplasm Cytoplasmic vesicle Early endosome Note=Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles. Belongs to the RIN (Ras interaction/interference) family. GTPase activator activity cytoplasm endosome early endosome signal transduction Rab guanyl-nucleotide exchange factor activity Rab GTPase binding cytoplasmic vesicle positive regulation of GTPase activity uc007ouc.1 uc007ouc.2 uc007ouc.3 uc007ouc.4 
ENSMUST00000056955.3 4933428G20Rik ENSMUST00000056955.3 RIKEN cDNA 4933428G20 gene (from RefSeq NR_177963.1) ENSMUST00000056955.1 ENSMUST00000056955.2 NR_177963 uc033fzq.1 uc033fzq.2 uc033fzq.3 uc033fzq.1 uc033fzq.2 uc033fzq.3 
ENSMUST00000056962.11 Ccdc74a ENSMUST00000056962.11 coiled-coil domain containing 74A, transcript variant 2 (from RefSeq NM_001418864.1) Ccdc74a E9Q9U8 E9Q9U8_MOUSE ENSMUST00000056962.1 ENSMUST00000056962.10 ENSMUST00000056962.2 ENSMUST00000056962.3 ENSMUST00000056962.4 ENSMUST00000056962.5 ENSMUST00000056962.6 ENSMUST00000056962.7 ENSMUST00000056962.8 ENSMUST00000056962.9 NM_001418864 uc012abv.1 uc012abv.2 uc012abv.3 molecular_function cellular_component biological_process uc012abv.1 uc012abv.2 uc012abv.3 
ENSMUST00000056972.6 Cmtr2 ENSMUST00000056972.6 cap methyltransferase 2 (from RefSeq NM_146215.4) CMTR2_MOUSE ENSMUST00000056972.1 ENSMUST00000056972.2 ENSMUST00000056972.3 ENSMUST00000056972.4 ENSMUST00000056972.5 Ftsjd1 NM_146215 Q3TYT6 Q8BWQ4 Q8R3E7 uc009nkp.1 uc009nkp.2 uc009nkp.3 uc009nkp.4 S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG- capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs. Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl- ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl- ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S- adenosyl-L-homocysteine; Xref=Rhea:RHEA:67024, Rhea:RHEA-COMP:17169, Rhea:RHEA-COMP:17170, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:167612, ChEBI:CHEBI:167614; EC=2.1.1.296; Evidence=; Nucleus Cytoplasm mRNA (nucleoside-2'-O-)-methyltransferase activity nucleus cytoplasm 7-methylguanosine mRNA capping mRNA processing methyltransferase activity transferase activity methylation cap1 mRNA methylation cap2 mRNA methylation uc009nkp.1 uc009nkp.2 uc009nkp.3 uc009nkp.4 
ENSMUST00000056977.14 Runx3 ENSMUST00000056977.14 runt related transcription factor 3, transcript variant 1 (from RefSeq NM_019732.2) ENSMUST00000056977.1 ENSMUST00000056977.10 ENSMUST00000056977.11 ENSMUST00000056977.12 ENSMUST00000056977.13 ENSMUST00000056977.2 ENSMUST00000056977.3 ENSMUST00000056977.4 ENSMUST00000056977.5 ENSMUST00000056977.6 ENSMUST00000056977.7 ENSMUST00000056977.8 ENSMUST00000056977.9 NM_019732 Q3U1Q3 Q3U1Q3_MOUSE Runx3 uc008vgb.1 uc008vgb.2 uc008vgb.3 Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. Nucleus DNA binding transcription factor activity, sequence-specific DNA binding ATP binding nucleus nucleolus cytoplasm cytosol regulation of transcription, DNA-templated protein phosphorylation intracellular membrane-bounded organelle positive regulation of transcription, DNA-templated response to transforming growth factor beta uc008vgb.1 uc008vgb.2 uc008vgb.3 
ENSMUST00000056978.8 Kif13a ENSMUST00000056978.8 kinesin family member 13A (from RefSeq NM_010617.2) ENSMUST00000056978.1 ENSMUST00000056978.2 ENSMUST00000056978.3 ENSMUST00000056978.4 ENSMUST00000056978.5 ENSMUST00000056978.6 ENSMUST00000056978.7 F8VQ75 F8VQ75_MOUSE Kif13a NM_010617 uc007qhn.1 uc007qhn.2 uc007qhn.3 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding motor activity microtubule motor activity ATP binding centrosome intracellular protein transport microtubule-based movement microtubule binding endosome to lysosome transport endosome membrane midbody melanosome organization regulation of cytokinesis cargo loading into vesicle plus-end-directed vesicle transport along microtubule uc007qhn.1 uc007qhn.2 uc007qhn.3 
ENSMUST00000056991.6 Spata46 ENSMUST00000056991.6 spermatogenesis associated 46 (from RefSeq NM_001039593.2) ENSMUST00000056991.1 ENSMUST00000056991.2 ENSMUST00000056991.3 ENSMUST00000056991.4 ENSMUST00000056991.5 NM_001039593 Q4FZF2 SPT46_MOUSE uc007dmd.1 uc007dmd.2 uc007dmd.3 Plays a role in spermiogenesis and fertilization. Nucleus membrane Note=Located throughout the subacrosomal area (PubMed:27488028). Testis-specific (PubMed:27488028). Increases in the third week postnatal and gradually increased until the adult stage (PubMed:27488028). Deficient mice develop and grow normally. Knockout males, but not females, exhibit subfertile capacity. Deficient mice are characterized by abnormal sperm head shape and a failure of sperm-egg fusion (PubMed:27488028). molecular_function nucleus spermatogenesis fusion of sperm to egg plasma membrane membrane cell differentiation nuclear membrane uc007dmd.1 uc007dmd.2 uc007dmd.3 
ENSMUST00000056997.15 Cdadc1 ENSMUST00000056997.15 cytidine and dCMP deaminase domain containing 1, transcript variant 2 (from RefSeq NM_027986.3) CDAC1_MOUSE ENSMUST00000056997.1 ENSMUST00000056997.10 ENSMUST00000056997.11 ENSMUST00000056997.12 ENSMUST00000056997.13 ENSMUST00000056997.14 ENSMUST00000056997.2 ENSMUST00000056997.3 ENSMUST00000056997.4 ENSMUST00000056997.5 ENSMUST00000056997.6 ENSMUST00000056997.7 ENSMUST00000056997.8 ENSMUST00000056997.9 NM_027986 Q8BMD5 Q8BYL2 Q8BYN1 Q8C014 Q922P4 Q99KL2 Q9D7F3 uc007ueo.1 uc007ueo.2 uc007ueo.3 uc007ueo.4 uc007ueo.5 Catalyzes the deamination of cytidine and deoxycytidine into uridine and deoxyuridine, respectively. May play an important role in testicular development and spermatogenesis. Reaction=2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+); Xref=Rhea:RHEA:13433, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15698, ChEBI:CHEBI:16450, ChEBI:CHEBI:28938; EC=3.5.4.5; Evidence=; Reaction=cytidine + H(+) + H2O = NH4(+) + uridine; Xref=Rhea:RHEA:16069, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:17562, ChEBI:CHEBI:28938; EC=3.5.4.5; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8BMD5-1; Sequence=Displayed; Name=2; IsoId=Q8BMD5-2; Sequence=VSP_027820, VSP_027823; Name=3; IsoId=Q8BMD5-3; Sequence=VSP_027821, VSP_027822; Name=4; IsoId=Q8BMD5-4; Sequence=VSP_027819, VSP_027824; Name=6; IsoId=Q8BMD5-6; Sequence=VSP_027817, VSP_027818; Belongs to the cytidine and deoxycytidylate deaminase family. Sequence=BAB26191.1; Type=Frameshift; Evidence=; catalytic activity cytidine deaminase activity dCMP deaminase activity nucleus cytoplasm dUMP biosynthetic process dTMP biosynthetic process zinc ion binding cytidine deamination hydrolase activity protein homodimerization activity metal ion binding importin-alpha family protein binding DNA cytosine deamination uc007ueo.1 uc007ueo.2 uc007ueo.3 uc007ueo.4 uc007ueo.5 
ENSMUST00000057015.8 Slc4a7 ENSMUST00000057015.8 solute carrier family 4, sodium bicarbonate cotransporter, member 7, transcript variant 11 (from RefSeq NM_001033270.2) ENSMUST00000057015.1 ENSMUST00000057015.2 ENSMUST00000057015.3 ENSMUST00000057015.4 ENSMUST00000057015.5 ENSMUST00000057015.6 ENSMUST00000057015.7 F8VQC9 F8VQC9_MOUSE NM_001033270 Slc4a7 uc007sgp.1 uc007sgp.2 uc007sgp.3 Basolateral cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Lateral cell membrane ; Multi-pass membrane protein Membrane ; Multi- pass membrane protein Belongs to the anion exchanger (TC 2.A.31) family. inorganic anion exchanger activity plasma membrane ion transport anion transport anion transmembrane transporter activity inorganic anion transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane cytoplasmic vesicle stereocilium synapse anion transmembrane transport uc007sgp.1 uc007sgp.2 uc007sgp.3 
ENSMUST00000057019.9 Aplnr ENSMUST00000057019.9 apelin receptor (from RefSeq NM_011784.3) APJ_MOUSE Agtrl1 Apj ENSMUST00000057019.1 ENSMUST00000057019.2 ENSMUST00000057019.3 ENSMUST00000057019.4 ENSMUST00000057019.5 ENSMUST00000057019.6 ENSMUST00000057019.7 ENSMUST00000057019.8 NM_011784 Q3TZS9 Q9WV08 uc008kkb.1 uc008kkb.2 uc008kkb.3 uc008kkb.4 Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (PubMed:28854362, PubMed:28890073, PubMed:28663440). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (PubMed:28890073). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:28371822). Cell membrane ; Multi-pass membrane protein Note=After exposure to apelin (APLN) or apelin receptor early endogenous ligand (APELA), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane. Expressed in coronary endothelial cells (at protein level) (PubMed:28890073). Expressed in the embryo, allantoic and endothelial precursor cells of the yolk sac at 8 days post-coitum (dpc) (PubMed:28663440). Expressed in the secondary heart field and somite at 8.25 dpc (PubMed:28854362). Expressed in fetal allantoic endothelial cells at 9 dpc (PubMed:28663440). Expressed in the allantoid and the invading fetal vasculature of the placenta at 9.5 dpc (PubMed:28854362). Expressed in endothelial cells adjacent to syncytiotrophoblast cells at 10.5 dpc (PubMed:28663440). Expressed weakly in the embryonic heart at 11.5 dpc (PubMed:26611206). Expressed in the adult heart (PubMed:26611206). Expressed in endothelial cells and cardiomyocytes and weakly expressed in fibroblasts (PubMed:10473142, PubMed:26611206). Expressed from embryonic 8 days post-coitum (dpc) throughout the subsequent stages of formation of the cardiovascular system (PubMed:10473142). Up-regulated following myocardial infarction (MI) (at protein level) (PubMed:26611206). Mice lacking APLNR are not represented at Mendelian ratios. Mutant embryos exhibit incomplete penetrance of embryonic lethality (PubMed:28854362, PubMed:28663440). Mutant embryos display improper establishment of the fetal-maternal circulation, such as underdeveloped yolk sac vasculature, embryonic vascular malformations and impaired cardiac tube looping at 10.5 dpc (PubMed:28854362, PubMed:28663440). Mice heart of embryos show reduced coronary vessel growth at 13.5 dpc (PubMed:28890073). The heart of mutant adult mice induced by pressure overload display no improvement in cardiac dysfunction, hypertrophy and fibrosis in response to peptide hormone APELA treatment (PubMed:28371822). Conditional knockout in heart endothelial cells leads to delayed progression of vessel growth onto the heart and reduced branching of the developing coronary plexus in both the subepicardial and intramyocardial layers at 13.5 and 15.5 dpc (PubMed:28890073). Conditional endothelial-specific knockout adult mice, despite severe embryonic coronary vessel defects recover normal cardiac functions; endocardial-derived coronary vessels expand to rescue defective sinus venosus development in a APELA-APLNR-independent manner (PubMed:28890073). Double knockout mice of APLNR and APELA genes exhibited the same penetrance and embryonic lethality as single APELA knockout mice (PubMed:28854362). Belongs to the G-protein coupled receptor 1 family. angiogenesis blood vessel development vasculogenesis G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway multicellular organism development gastrulation heart development adult heart development membrane integral component of membrane negative regulation of cAMP-mediated signaling positive regulation of angiogenesis regulation of body fluid levels positive regulation of release of sequestered calcium ion into cytosol apelin receptor activity apelin receptor signaling pathway coronary vasculature development positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of inhibitory G-protein coupled receptor phosphorylation uc008kkb.1 uc008kkb.2 uc008kkb.3 uc008kkb.4 
ENSMUST00000057021.9 Osr1 ENSMUST00000057021.9 odd-skipped related transcription factor 1 (from RefSeq NM_011859.3) ENSMUST00000057021.1 ENSMUST00000057021.2 ENSMUST00000057021.3 ENSMUST00000057021.4 ENSMUST00000057021.5 ENSMUST00000057021.6 ENSMUST00000057021.7 ENSMUST00000057021.8 NM_011859 OSR1_MOUSE Odd1 Q9WVG7 uc007nao.1 uc007nao.2 uc007nao.3 uc007nao.4 Transcription factor that plays a role in the regulation of embryonic heart and urogenital development. Nucleus During early embryogenesis it is expressed in the intermediate mesoderm and in a dynamic pattern during limb and branchial arch development. Is expressed from the earliest stage of intermediate development. Is expressed in the dorsal atrial wall, including the developing primary atrial septum and the venous valve. Transcriptionally regulated by Ikzf1 and Runx2. Mice die prenatally with severe heart defects including defective atrioventricular junction and venous valves. They never initiate metanephric kidney formation. Nephrogenic mesenchyme undergo massive apoptosis, which causes a disruption of nephric duct elongation and failure of metanephric induction. Belongs to the Odd C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding urogenital system development metanephros development ureteric bud development mesonephros development chondrocyte differentiation nucleic acid binding protein binding nucleus cytosol heart development gonad development positive regulation of gene expression extrinsic component of membrane cell differentiation positive regulation of bone mineralization negative regulation of epithelial cell differentiation embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic skeletal limb joint morphogenesis middle ear morphogenesis odontogenesis embryonic digit morphogenesis negative regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter metal ion binding intermediate mesoderm development pronephros development stem cell differentiation positive regulation of epithelial cell proliferation palate development embryonic skeletal joint morphogenesis cellular response to retinoic acid metanephric mesenchyme development cell proliferation involved in kidney development metanephric mesenchyme morphogenesis mesangial cell development metanephric mesenchymal cell differentiation posterior mesonephric tubule development specification of anterior mesonephric tubule identity specification of posterior mesonephric tubule identity mesonephric duct morphogenesis negative regulation of nephron tubule epithelial cell differentiation renal vesicle progenitor cell differentiation ureter urothelium development metanephric epithelium development metanephric smooth muscle tissue development metanephric nephron tubule development metanephric glomerulus vasculature development metanephric interstitial fibroblast development pattern specification involved in metanephros development embryonic skeletal joint development metanephric cap mesenchymal cell proliferation involved in metanephros development negative regulation of creatine transmembrane transporter activity positive regulation of gastrulation negative regulation of sodium ion transmembrane transporter activity uc007nao.1 uc007nao.2 uc007nao.3 uc007nao.4 
ENSMUST00000057023.12 P4ha3 ENSMUST00000057023.12 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III (from RefSeq NM_177161.4) ENSMUST00000057023.1 ENSMUST00000057023.10 ENSMUST00000057023.11 ENSMUST00000057023.2 ENSMUST00000057023.3 ENSMUST00000057023.4 ENSMUST00000057023.5 ENSMUST00000057023.6 ENSMUST00000057023.7 ENSMUST00000057023.8 ENSMUST00000057023.9 H7BX23 H7BX23_MOUSE NM_177161 P4ha3 uc009imt.1 uc009imt.2 uc009imt.3 Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Endoplasmic reticulum lumen Belongs to the P4HA family. procollagen-proline 4-dioxygenase activity iron ion binding endoplasmic reticulum oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen peptidyl-proline hydroxylation L-ascorbic acid binding oxidation-reduction process uc009imt.1 uc009imt.2 uc009imt.3 
ENSMUST00000057026.10 Slc25a47 ENSMUST00000057026.10 solute carrier family 25, member 47 (from RefSeq NM_001012310.2) ENSMUST00000057026.1 ENSMUST00000057026.2 ENSMUST00000057026.3 ENSMUST00000057026.4 ENSMUST00000057026.5 ENSMUST00000057026.6 ENSMUST00000057026.7 ENSMUST00000057026.8 ENSMUST00000057026.9 Hdmcp NM_001012310 Q3UES2 Q5FW58 Q6IS41 Q7TPP3 S2547_MOUSE Slc25a47 uc007pae.1 uc007pae.2 Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated. Reaction=NAD(+)(in) = NAD(+)(out); Xref=Rhea:RHEA:65408, ChEBI:CHEBI:57540; Evidence=; Reaction=acetyl-CoA(in) = acetyl-CoA(out); Xref=Rhea:RHEA:75039, ChEBI:CHEBI:57288; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Mitochondrion outer membrane ; Multi-pass membrane protein Specifically expressed in liver (at protein level). Mutant mice show increased hepatic steatosis upon methionine- and choline-deficient or high-fat diet associated with increased hepatic lipid droplets and triglycerides and cholesterol levels. They spontaneously develop hepatocellular carcinomas. SLC25A47 is transcriptionally up-regulated in response to antihyperglycemic drug metformin. Promotes metformin pharmacological effects. Belongs to the mitochondrial carrier (TC 2.A.29) family. Sequence=AAH55027.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; mitochondrion mitochondrial inner membrane acyl carnitine transport acyl carnitine transmembrane transporter activity membrane integral component of membrane transmembrane transporter activity transmembrane transport acyl carnitine transmembrane transport uc007pae.1 uc007pae.2 
ENSMUST00000057028.15 Camsap3 ENSMUST00000057028.15 calmodulin regulated spectrin-associated protein family, member 3, transcript variant 2 (from RefSeq NM_027171.3) CAMP3_MOUSE Camsap3 E9Q5B0 ENSMUST00000057028.1 ENSMUST00000057028.10 ENSMUST00000057028.11 ENSMUST00000057028.12 ENSMUST00000057028.13 ENSMUST00000057028.14 ENSMUST00000057028.2 ENSMUST00000057028.3 ENSMUST00000057028.4 ENSMUST00000057028.5 ENSMUST00000057028.6 ENSMUST00000057028.7 ENSMUST00000057028.8 ENSMUST00000057028.9 Kiaa1543 NM_027171 Q5DTW9 Q80VC9 Q8BUZ0 U5LGR7 U5LGS1 U5LGS5 U5LGT0 U5LHT8 U5LHU4 U5LHW1 U5LHW4 U5LHW9 U5LK15 U5LK19 U5LK24 U5LK70 U5LK74 U5LK79 uc009krw.1 uc009krw.2 uc009krw.3 uc009krw.4 Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24706919, PubMed:26715742). Specifically recognizes growing microtubule minus- ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule- nucleating proteins or other factors and protects microtubule minus- ends from depolymerization (PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24706919). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (By similarity). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule- organizing center that directs intracellular transport in the early embryo (PubMed:28860385). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (By similarity). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (By similarity). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (PubMed:32482850). Interacts with PLEKHA7 (By similarity). Interacts with CAMSAP2 (PubMed:23169647). Interacts with KATNA1 and KATNB1; leading to regulate the length of CAMSAP3-decorated microtubule stretches (By similarity). Interacts with AKAP9; regulating Golgi assembly in epithelial cells (By similarity). Interacts with MACF1 (By similarity). Interacts with isoform C of CDH23; leading to inhibit CAMSAP3 ability to induce microtubule bundle formation (PubMed:27349180). Interacts with AKNA (PubMed:30787442). Q80VC9; Q8C1B1: Camsap2; NbExp=2; IntAct=EBI-2125556, EBI-8839434; Cytoplasm, cytoskeleton ll junction, adherens junction Cytoplasm Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, cilium basal body Note=Scattered in the cytoplasm, associated with the minus-end of microtubules and also detected at the centrosomes (PubMed:24706919, PubMed:26715742). Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound (By similarity). Localizes along zonula adherens only at mature cell-cell contacts (By similarity). In early embryos, accumulates at the microtubule bridges that connect pairs of cells: this structure is present in early embryos, which lack centrosomes (PubMed:28860385). This cytokinetic bridge does not undergo stereotypical abscission after cell division (PubMed:28860385). Accumulates to the pericentrosomal region following interaction with KATNA1 (By similarity). Event=Alternative splicing; Named isoforms=17; Name=1; Synonyms=Ld ; IsoId=Q80VC9-1; Sequence=Displayed; Name=2; IsoId=Q80VC9-2; Sequence=VSP_013705; Name=3; Synonyms=Lc variant 2 ; IsoId=Q80VC9-3; Sequence=VSP_059237; Name=4; Synonyms=Lb variant 2 ; IsoId=Q80VC9-4; Sequence=VSP_059238; Name=5; Synonyms=La variant 2 ; IsoId=Q80VC9-5; Sequence=VSP_059239; Name=6; Synonyms=Sc variant 2 ; IsoId=Q80VC9-6; Sequence=VSP_059237, VSP_059241; Name=7; Synonyms=Sb variant 2 ; IsoId=Q80VC9-7; Sequence=VSP_059238, VSP_059241; Name=8; Synonyms=Sa variant 2 ; IsoId=Q80VC9-8; Sequence=VSP_059239, VSP_059241; Name=9; Synonyms=Sd variant 2 ; IsoId=Q80VC9-9; Sequence=VSP_059241; Name=10; Synonyms=Ld variant 1 ; IsoId=Q80VC9-10; Sequence=VSP_059240; Name=11; Synonyms=Lb variant 1 ; IsoId=Q80VC9-11; Sequence=VSP_059238, VSP_059240; Name=12; Synonyms=Lc variant 1 ; IsoId=Q80VC9-12; Sequence=VSP_059237, VSP_059240; Name=13; Synonyms=Sd variant 1 ; IsoId=Q80VC9-13; Sequence=VSP_059240, VSP_059241; Name=14; Synonyms=La variant 1 ; IsoId=Q80VC9-14; Sequence=VSP_059239, VSP_059240; Name=15; Synonyms=Sc variant 1 ; IsoId=Q80VC9-15; Sequence=VSP_059237, VSP_059240, VSP_059241; Name=16; Synonyms=Sb variant 1 ; IsoId=Q80VC9-16; Sequence=VSP_059238, VSP_059240, VSP_059241; Name=17; Synonyms=Sa variant 1 ; IsoId=Q80VC9-17; Sequence=VSP_059239, VSP_059240, VSP_059241; Expressed at the apical surface of respiratory epithelia, as well as in the acini of submucosal glands (at protein level)(PubMed:32482850). In cochlea, restricted to the organ of Corti and increases during development (at protein level) (PubMed:24244856). Highly expressed in both sensory hair cells and supporting cells (PubMed:24244856). The CKK domain binds microtubules and specifically recognizes the minus-end of microtubules. Mice are viable but show growth defects (PubMed:26715742). Disorganization of epithelial architecture, characterized by impaired apical-to-basal polarity of microtubules in epithelial cells (PubMed:26715742). Defects in the stereotypic positioning of the nucleus and Golgi apparatus (PubMed:26715742). Mice display subfertility in both sexes and severe nasal airway blockage leading to coughing, sneezing, hyposmia and rhinosinusitis (PubMed:32482850). Majority of cilia lack the central microtubule pair in their axoneme and display disorientated basal bodies and defects in ciliary motion, which is no longer synchronized (PubMed:32482850). Belongs to the CAMSAP1 family. microtubule cytoskeleton organization in utero embryonic development protein binding calmodulin binding cytoplasm centrosome cytoskeleton microtubule adherens junction zonula adherens negative regulation of microtubule depolymerization microtubule binding embryo development ending in birth or egg hatching negative regulation of phosphatase activity cell junction regulation of cell migration spectrin binding establishment or maintenance of microtubule cytoskeleton polarity regulation of microtubule polymerization cytoplasmic microtubule organization neuron projection development regulation of organelle organization microtubule anchoring microtubule minus-end establishment of epithelial cell apical/basal polarity zonula adherens maintenance microtubule minus-end binding actin filament binding regulation of focal adhesion assembly regulation of microtubule cytoskeleton organization epithelial cell-cell adhesion protein transport along microtubule regulation of Golgi organization uc009krw.1 uc009krw.2 uc009krw.3 uc009krw.4 
ENSMUST00000057043.10 Tceanc2 ENSMUST00000057043.10 transcription elongation factor A (SII) N-terminal and central domain containing 2 (from RefSeq NM_025617.2) ENSMUST00000057043.1 ENSMUST00000057043.2 ENSMUST00000057043.3 ENSMUST00000057043.4 ENSMUST00000057043.5 ENSMUST00000057043.6 ENSMUST00000057043.7 ENSMUST00000057043.8 ENSMUST00000057043.9 NM_025617 Q8R2M0 Q9CZZ2 Q9D7X9 TEAN2_MOUSE Tdeanc2 uc008tzh.1 uc008tzh.2 uc008tzh.3 Nucleus Belongs to the TCEANC2 family. Sequence=BAB27962.1; Type=Frameshift; Evidence=; molecular_function cellular_component nucleus transcription, DNA-templated uc008tzh.1 uc008tzh.2 uc008tzh.3 
ENSMUST00000057054.8 Meox1 ENSMUST00000057054.8 mesenchyme homeobox 1 (from RefSeq NM_010791.3) ENSMUST00000057054.1 ENSMUST00000057054.2 ENSMUST00000057054.3 ENSMUST00000057054.4 ENSMUST00000057054.5 ENSMUST00000057054.6 ENSMUST00000057054.7 MEOX1_MOUSE Mox-1 Mox1 NM_010791 P32442 Q543E8 uc007lpx.1 uc007lpx.2 uc007lpx.3 Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:19520072). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome (PubMed:15024065). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome (By similarity). Nucleus Cytoplasm Note=Localizes predominantly in the nucleus. Heart, lateral plate derivatives, kidney, loose connective tissue at sites of bone formation and skeletal muscle- connective tissue apposition. After 7 dpc it is expressed in mesoderm lying posterior of the future primordial head and heart. Between 7.5 and 9.5 dpc it is expressed in presomitic mesoderm, epithelial and differentiating somites and in lateral plate mesoderm. In the body of mid-gestation embryos it is restricted to loose undifferentiated mesenchyme. Mice display mild defects in sclerotome derived vertebral and rib bones (PubMed:12925591). Abnormalities are restricted to the sclerotome and its derivatives and are characterized by a remodeling of the cranio-cervical joints, leading to the assimilation of the atlas into the basioccipital bone so that the skull rests on the axis (PubMed:19520072). Mice lacking Meox1 and Meox2 show extremely disrupted somite morphogenesis, patterning and differentiation. They lack an axial skeleton and skeletal muscles are severely deficient (PubMed:12925591). RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding somite specification DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated multicellular organism development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter hematopoietic stem cell differentiation somite development sclerotome development HMG box domain binding uc007lpx.1 uc007lpx.2 uc007lpx.3 
ENSMUST00000057067.10 Mei4 ENSMUST00000057067.10 meiotic double-stranded break formation protein 4, transcript variant 1 (from RefSeq NM_175213.4) ENSMUST00000057067.1 ENSMUST00000057067.2 ENSMUST00000057067.3 ENSMUST00000057067.4 ENSMUST00000057067.5 ENSMUST00000057067.6 ENSMUST00000057067.7 ENSMUST00000057067.8 ENSMUST00000057067.9 MEI4_MOUSE Mei4 NM_175213 Q4V9Z7 Q8BRM6 Q8C4E8 uc009qvp.1 uc009qvp.2 uc009qvp.3 Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:25795304, PubMed:27723721). Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721). Part of the MCD recombinosome complex, at least composed of IHO1, REC114 and MEI4 (PubMed:27723721, PubMed:30569039). Forms a complex with REC114; the interaction is required for MEI4 stability (PubMed:20551173, PubMed:30569039). Interacts (via N-terminal domain) with REC114 (via C-terminal domain) (PubMed:20551173, PubMed:30569039). Interacts with IHO1 (PubMed:30569039). Q8BRM6; Q9CWH4: Rec114; NbExp=5; IntAct=EBI-9548252, EBI-9548270; Chromosome Note=Specifically localizes to unsynapsed chromosomal regions during meiosis (PubMed:25795304, PubMed:27723721). Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema, decreases at zygonema and is strongly reduced in pachynema and subsequent stages (PubMed:20551173). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BRM6-1; Sequence=Displayed; Name=2; IsoId=Q8BRM6-2; Sequence=VSP_034675; Expressed in adult testis and brain and in embryonic ovary. In the testis, expression is detected at 4 days postpartum (dpp) with a peak between days 10 and 14. Levels decrease by 18 dpp with a further decrease in the adult. Deficient DNA double-strand break formation during meiotic recombination. Belongs to the MEI4L family. Sequence=BAC38486.1; Type=Frameshift; Evidence=; lateral element protein binding chromosome DNA recombination synapsis spermatogenesis meiotic DNA double-strand break formation oogenesis meiotic cell cycle uc009qvp.1 uc009qvp.2 uc009qvp.3 
ENSMUST00000057070.9 Zfp456 ENSMUST00000057070.9 zinc finger protein 456 (from RefSeq NM_001001186.4) B2RUK9 B2RUK9_MOUSE ENSMUST00000057070.1 ENSMUST00000057070.2 ENSMUST00000057070.3 ENSMUST00000057070.4 ENSMUST00000057070.5 ENSMUST00000057070.6 ENSMUST00000057070.7 ENSMUST00000057070.8 NM_001001186 Zfp456 uc007rar.1 uc007rar.2 uc007rar.3 May be involved in transcriptional regulation. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007rar.1 uc007rar.2 uc007rar.3 
ENSMUST00000057072.6 Prdx6b ENSMUST00000057072.6 peroxiredoxin 6B (from RefSeq NM_177256.5) ENSMUST00000057072.1 ENSMUST00000057072.2 ENSMUST00000057072.3 ENSMUST00000057072.4 ENSMUST00000057072.5 NM_177256 Prdx6-ps1 Prdx6-rs1 Prdx6-rs1-ps Prdx6b Q8BG37 Q8BG37_MOUSE uc008khh.1 uc008khh.2 uc008khh.3 uc008khh.4 uc008khh.5 This intronless gene is similar to the multi-exon peroxiredoxin 6 gene located on chromosome 1. It is transcribed and the ORF is intact compared to that of the peroxiredoxin 6 gene. This gene could be considered a transcribed pseudogene based on a failure to detect the protein in vivo in PMID:14644414. However, NCBI is representing the protein due to mass spectrometry data in PMID:18614015, which detected at least one peptide that is specific for this protein. [provided by RefSeq, Mar 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript is intronless :: AK077012.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35983, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35984; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2- diacyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:12937, ChEBI:CHEBI:57287, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:58342; EC=2.3.1.23; Evidence=; Reaction=a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O; Xref=Rhea:RHEA:62632, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.27; Evidence= Cytoplasm Belongs to the peroxiredoxin family. Prx6 subfamily. mitochondrion cytosol antioxidant activity oxidoreductase activity cell redox homeostasis peroxiredoxin activity oxidation-reduction process cellular oxidant detoxification uc008khh.1 uc008khh.2 uc008khh.3 uc008khh.4 uc008khh.5 
ENSMUST00000057076.5 Defb9 ENSMUST00000057076.5 defensin beta 9 (from RefSeq NM_139219.3) DEFB9_MOUSE ENSMUST00000057076.1 ENSMUST00000057076.2 ENSMUST00000057076.3 ENSMUST00000057076.4 NM_139219 Q8R2I6 uc009lcc.1 uc009lcc.2 uc009lcc.3 uc009lcc.4 Has antibacterial activity. Secreted Weakly expressed in adult and neonatal brain. Belongs to the beta-defensin family. molecular_function cellular_component extracellular region defense response biological_process defense response to bacterium uc009lcc.1 uc009lcc.2 uc009lcc.3 uc009lcc.4 
ENSMUST00000057080.4 Taar6 ENSMUST00000057080.4 trace amine-associated receptor 6 (from RefSeq NM_001010828.1) ENSMUST00000057080.1 ENSMUST00000057080.2 ENSMUST00000057080.3 Gm228 NM_001010828 Q5QD13 TAAR6_MOUSE uc007eqi.1 uc007eqi.2 Orphan olfactory receptor specific for trace amines. Cell membrane ; Multi-pass membrane protein Specifically expressed in neurons of the olfactory epithelium, to discrete glomeruli predominantly localized to a confined bulb region. Present in a ventral area of the main olfactory epithelium. Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2- phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled amine receptor activity membrane integral component of membrane uc007eqi.1 uc007eqi.2 
ENSMUST00000057101.13 Akap4 ENSMUST00000057101.13 A kinase anchor protein 4, transcript variant 1 (from RefSeq NM_009651.4) AKAP4_MOUSE Akap82 B1AXM7 ENSMUST00000057101.1 ENSMUST00000057101.10 ENSMUST00000057101.11 ENSMUST00000057101.12 ENSMUST00000057101.2 ENSMUST00000057101.3 ENSMUST00000057101.4 ENSMUST00000057101.5 ENSMUST00000057101.6 ENSMUST00000057101.7 ENSMUST00000057101.8 ENSMUST00000057101.9 Fsc1 NM_009651 Q60630 Q60662 Q8R2G7 uc009slc.1 uc009slc.2 uc009slc.3 uc009slc.4 uc009slc.5 Major structural component of sperm fibrous sheath. Plays a role in sperm motility (PubMed:12167408). Interacts with PRKAR1A and PRKAR2A (PubMed:9852104). Interacts with ENO4 (PubMed:23446454). Cell projection, cilium, flagellum Note=Localizes to the principle piece of the sperm flagellum. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60662-1; Sequence=Displayed; Name=2; IsoId=Q60662-2; Sequence=VSP_004100; Spermatid. Post-meiotic phase of spermatogenesis. RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. Belongs to the AKAP110 family. protein binding cytoplasm cilium transmembrane receptor protein serine/threonine kinase signaling pathway protein localization Z disc cell projection organization flagellated sperm motility motile cilium sperm fibrous sheath cell projection motile cilium assembly establishment of protein localization perinuclear region of cytoplasm protein kinase A binding sperm principal piece uc009slc.1 uc009slc.2 uc009slc.3 uc009slc.4 uc009slc.5 
ENSMUST00000057104.7 Or51a24 ENSMUST00000057104.7 olfactory receptor family 51 subfamily A member 24 (from RefSeq NM_207144.1) ENSMUST00000057104.1 ENSMUST00000057104.2 ENSMUST00000057104.3 ENSMUST00000057104.4 ENSMUST00000057104.5 ENSMUST00000057104.6 NM_207144 Olfr645 Or51a24 Q7TRQ1 Q7TRQ1_MOUSE uc009ivi.1 uc009ivi.2 uc009ivi.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ivi.1 uc009ivi.2 uc009ivi.3 
ENSMUST00000057110.11 Eif3j2 ENSMUST00000057110.11 eukaryotic translation initiation factor 3, subunit J2 (from RefSeq NM_001256055.1) EI3JB_MOUSE ENSMUST00000057110.1 ENSMUST00000057110.10 ENSMUST00000057110.2 ENSMUST00000057110.3 ENSMUST00000057110.4 ENSMUST00000057110.5 ENSMUST00000057110.6 ENSMUST00000057110.7 ENSMUST00000057110.8 ENSMUST00000057110.9 Eif3s1-2 Gm9781 NM_001256055 Q66JS6 Q8BUW6 uc033hgq.1 uc033hgq.2 uc033hgq.3 uc033hgq.4 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Cytoplasm Phosphorylated. Phosphorylation is enhanced upon serum stimulation. Belongs to the eIF-3 subunit J family. formation of cytoplasmic translation initiation complex cytoplasmic translational initiation translation initiation factor activity cytoplasm cytosol eukaryotic translation initiation factor 3 complex translation translational initiation eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex uc033hgq.1 uc033hgq.2 uc033hgq.3 uc033hgq.4 
ENSMUST00000057113.3 H2al3 ENSMUST00000057113.3 H2A histone family member L3 (from RefSeq NM_029229.1) 4930557A04Rik ENSMUST00000057113.1 ENSMUST00000057113.2 H2al3 NM_029229 Q9D4U4 Q9D4U4_MOUSE uc012hes.1 uc012hes.2 uc012hes.3 nuclear chromatin DNA binding chromatin organization protein heterodimerization activity uc012hes.1 uc012hes.2 uc012hes.3 
ENSMUST00000057115.7 Isca1 ENSMUST00000057115.7 iron-sulfur cluster assembly 1 (from RefSeq NM_026921.4) ENSMUST00000057115.1 ENSMUST00000057115.2 ENSMUST00000057115.3 ENSMUST00000057115.4 ENSMUST00000057115.5 ENSMUST00000057115.6 Hbld2 ISCA1_MOUSE NM_026921 Q5SZT5 Q9D924 uc007qvd.1 uc007qvd.2 uc007qvd.3 Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. Interacts with CRY2, but not with CRY1 (in vitro). Mitochondrion Belongs to the HesB/IscA family. structural molecule activity mitochondrion iron-sulfur cluster assembly metal ion binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding protein maturation by iron-sulfur cluster transfer uc007qvd.1 uc007qvd.2 uc007qvd.3 
ENSMUST00000057145.7 Hcar2 ENSMUST00000057145.7 hydroxycarboxylic acid receptor 2 (from RefSeq NM_030701.3) ENSMUST00000057145.1 ENSMUST00000057145.2 ENSMUST00000057145.3 ENSMUST00000057145.4 ENSMUST00000057145.5 ENSMUST00000057145.6 Gpr109 Gpr109a Gpr109b HCAR2_MOUSE NM_030701 Niacr1 Pumag Q9EP66 uc008zop.1 uc008zop.2 uc008zop.3 uc008zop.4 uc008zop.5 Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)- protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. Cell membrane; Multi-pass membrane protein. Expressed in lungs, spleen, heart, skeletal muscle and adipose tissue. By interferon-gamma in macrophages. Niacin administration has no effect on serum adiponectin levels in contrast to wild-type mice where levels are decreased. Belongs to the G-protein coupled receptor 1 family. purinergic nucleotide receptor activity neutrophil apoptotic process G-protein coupled receptor activity GTP binding plasma membrane apoptotic process signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane cell junction positive regulation of neutrophil apoptotic process negative regulation of lipid catabolic process positive regulation of adiponectin secretion nicotinic acid receptor activity uc008zop.1 uc008zop.2 uc008zop.3 uc008zop.4 uc008zop.5 
ENSMUST00000057151.10 Tmem18 ENSMUST00000057151.10 transmembrane protein 18 (from RefSeq NM_172049.2) ENSMUST00000057151.1 ENSMUST00000057151.2 ENSMUST00000057151.3 ENSMUST00000057151.4 ENSMUST00000057151.5 ENSMUST00000057151.6 ENSMUST00000057151.7 ENSMUST00000057151.8 ENSMUST00000057151.9 NM_172049 Q3TUD9 Q8CID7 TMM18_MOUSE uc007ngu.1 uc007ngu.2 uc007ngu.3 uc007ngu.4 Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC) (By similarity). Forms homooligomers, independently of the DNA-binding domain. Cytoplasm Nucleus membrane ; Multi-pass membrane protein Belongs to the TMEM18 family. Sequence=AAH24093.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function DNA binding nucleus cytoplasm membrane integral component of membrane cell migration nuclear membrane uc007ngu.1 uc007ngu.2 uc007ngu.3 uc007ngu.4 
ENSMUST00000057169.5 Emilin3 ENSMUST00000057169.5 elastin microfibril interfacer 3, transcript variant 1 (from RefSeq NM_182840.2) EMIL3_MOUSE ENSMUST00000057169.1 ENSMUST00000057169.2 ENSMUST00000057169.3 ENSMUST00000057169.4 Emilin5 NM_182840 P59900 uc008nrk.1 uc008nrk.2 uc008nrk.3 uc008nrk.4 Secreted, extracellular space, extracellular matrix Cytoplasm Note=According to PubMed:14706625 it is cytoplasmic. At 9.5 dpc, expression is only observed in the tailbud and the hindgut. At 11.5 dpc the expression is found at sites of bone formation, i.e. surrounding mesenchymal condensates in the fore- and hindlimbs, the nose, the maxilla, and the other parts of the jaw. At 13.5 dpc, detected in perichondrium and around developing skeletons, but barely detectable in mature osteoblasts. At 14.5 dpc it is strongly expressed in the enteric nerves of the digestive tract and the bladder. Expression is also observed surrounding the main branches of the alveoli and surrounding sites of bone formation in skull and trunk. molecular_function extracellular region cytoplasm uc008nrk.1 uc008nrk.2 uc008nrk.3 uc008nrk.4 
ENSMUST00000057176.5 Lrit2 ENSMUST00000057176.5 leucine-rich repeat, immunoglobulin-like and transmembrane domains 2, transcript variant 1 (from RefSeq NM_173418.5) ENSMUST00000057176.1 ENSMUST00000057176.2 ENSMUST00000057176.3 ENSMUST00000057176.4 LRIT2_MOUSE Lrrc22 NM_173418 Q6PFC5 uc007tbt.1 uc007tbt.2 uc007tbt.3 Membrane; Single-pass type I membrane protein. molecular_function cellular_component biological_process membrane integral component of membrane uc007tbt.1 uc007tbt.2 uc007tbt.3 
ENSMUST00000057178.11 Nkx2-3 ENSMUST00000057178.11 NK2 homeobox 3 (from RefSeq NM_008699.2) ENSMUST00000057178.1 ENSMUST00000057178.10 ENSMUST00000057178.2 ENSMUST00000057178.3 ENSMUST00000057178.4 ENSMUST00000057178.5 ENSMUST00000057178.6 ENSMUST00000057178.7 ENSMUST00000057178.8 ENSMUST00000057178.9 NKX23_MOUSE NM_008699 Nkx-2.3 Nkx2c P97334 Q9QZ60 Q9WV67 uc008hok.1 uc008hok.2 Transcriptional regulator essential for normal development and functions of the small intestine and spleen. Activates directly MADCAM1 expression. Required for homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. May have a role during pharyngeal organogenesis. Nucleus Expressed in spleen and intestine. Also expressed in salivary gland and tongue. Expressed in gut mesenchyme during pre- and postnatal development. Expressed as well in the pharyngeal floor and pouches, and in the oral and branchial arch ectoderm. Expression persisted in the developing thyroid until birth, in mucous forming cells of salivary glands and in odontogenic epithelium of the mandible. Belongs to the NK-2 homeobox family. RNA polymerase II core promoter proximal region sequence-specific DNA binding leukocyte homeostasis plasma cell differentiation DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated triglyceride metabolic process immune response multicellular organism development post-embryonic development gland morphogenesis cell differentiation B cell differentiation macrophage differentiation regulation of cell proliferation odontogenesis of dentin-containing tooth CD4-positive, alpha-beta T cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter lymph node development spleen development mucosal-associated lymphoid tissue development Peyer's patch development digestive tract development post-embryonic digestive tract morphogenesis leukocyte migration uc008hok.1 uc008hok.2 
ENSMUST00000057186.2 Ghsr ENSMUST00000057186.2 growth hormone secretagogue receptor (from RefSeq NM_177330.4) ENSMUST00000057186.1 GHSR_MOUSE NM_177330 Q8BWX8 Q91Z82 Q99P50 uc008oto.1 uc008oto.2 Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine) (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. growth hormone secretagogue receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway spermatogenesis female pregnancy learning or memory actin polymerization or depolymerization adult feeding behavior response to hormone hormone-mediated signaling pathway cell surface negative regulation of norepinephrine secretion membrane integral component of membrane growth hormone-releasing hormone receptor activity peptide hormone binding growth hormone secretion response to food negative regulation of appetite positive regulation of appetite response to follicle-stimulating hormone response to estradiol negative regulation of interleukin-1 beta production cellular response to insulin stimulus ghrelin secretion positive regulation of multicellular organism growth negative regulation of tumor necrosis factor biosynthetic process hormone binding neuron projection regulation of hindgut contraction positive regulation of insulin-like growth factor receptor signaling pathway membrane raft negative regulation of interleukin-6 biosynthetic process positive regulation of fatty acid metabolic process positive regulation of growth negative regulation of insulin secretion decidualization negative regulation of inflammatory response regulation of synapse assembly regulation of transmission of nerve impulse regulation of growth hormone secretion regulation of feeding behavior response to growth hormone cellular response to lipopolysaccharide response to dexamethasone negative regulation of locomotion involved in locomotory behavior cellular response to thyroid hormone stimulus postsynapse glutamatergic synapse positive regulation of sprouting angiogenesis positive regulation of eating behavior response to monosodium glutamate positive regulation of small intestine smooth muscle contraction negative regulation of tumor necrosis factor secretion regulation of gastric motility positive regulation of vascular endothelial cell proliferation cellular response to insulin-like growth factor stimulus negative regulation of macrophage apoptotic process uc008oto.1 uc008oto.2 
ENSMUST00000057188.7 Cnr1 ENSMUST00000057188.7 cannabinoid receptor 1, transcript variant 1 (from RefSeq NM_007726.5) CNR1_MOUSE ENSMUST00000057188.1 ENSMUST00000057188.2 ENSMUST00000057188.3 ENSMUST00000057188.4 ENSMUST00000057188.5 ENSMUST00000057188.6 NM_007726 P47746 Q5SF33 uc008sfw.1 uc008sfw.2 G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG) (PubMed:9888857, PubMed:22388959). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain (PubMed:9888857, PubMed:27828947). Signaling typically involves reduction in cyclic AMP (PubMed:8832654, PubMed:27828947). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses (PubMed:25707796, PubMed:27828947). At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2 (PubMed:27828947). In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid- induced increase in SREBF1 and FASN gene expression (PubMed:25869131). In response to cannabinoids, drives the release of orexigenic beta- endorphin, but not that of melanocyte-stimulating hormone alpha/alpha- MSH, from hypothalamic POMC neurons, hence promoting food intake (PubMed:25707796). In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission (PubMed:22388959). Also reduces excitatory synaptic transmission (PubMed:27828947). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (By similarity). In cerebral vascular smooth muscle cells, cannabinoid- induced inhibition of voltage-gated Ca(2+) channels leads to vasodilation and decreased vascular tone (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia (PubMed:22841573). In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes (PubMed:15864349). In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes (PubMed:15864349, PubMed:21987372). May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake (PubMed:21987372). Peripherally modulates energy metabolism. In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (PubMed:26671069). In response to cannabinoid anandamide, elicits a pro-inflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion. In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta- cells (PubMed:23955712). Hemopressin, a peptide derived from hemoglobin subunit alpha (HBA1 and/or HBA2), acts as an antagonist peptide: hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling. Interacts (via C-terminus) with CNRIP1 (By similarity). Associates with G protein alpha subunits, including G(i) alpha-1/GNAI1, G(i) alpha-3/GNAI3 and G(o)-alpha/GNAO1; palmitoylation is important for interaction with GNAI3 and GNAO1 (PubMed:27828947). Cell membrane ulti-pass membrane protein Mitochondrion outer membrane ll projection, axon Presynapse Note=In CA1 hippocampal neurons, 15.5% of total protein is localized in mitochondria (PubMed:22388959). Found on presynaptic axon terminals in some GABAergic neurons in the somatosensory cortex (By similarity). In striated muscles, predominantly located in mitochondria (PubMed:27826249). Unexpectedly, in the mitochondria, the C-terminus is located in the mitochondrial intermembrane space, a compartment topologically considered as extracellular. In canonical seven-transmembrane G-protein coupled receptors, the C-terminus is cytosolic (PubMed:22388959). Expressed in brain neurons (at protein level) (PubMed:22388959). Detected throughout the striatum, cortex and hippocampus, with highest levels in the lateral striatum (PubMed:15606779, PubMed:10891614, PubMed:22388959). In rostral brain regions, high expression levels in the dorsal lateral striatum, while in the caudal brain regions, high levels are observed in the ventral lateral striatum (PubMed:10891614). Expressed in neurons (PubMed:10891614). In the hypothalamus, expressed in both GABAergic and glutamatergic presynaptic terminals of POMC neurons (at protein level) (PubMed:25869131, PubMed:25707796). Expressed in striated muscles, including skeletal muscles (gastrocnemius and rectus abdominis) and myocardium (at protein level) (PubMed:26671069, PubMed:27826249). Expressed in the liver, with highest levels in Kupffer cells and lower levels in endothelial cells as well as hepatocytes, particularly in perivascular areas (at protein level) (PubMed:15864349, PubMed:21987372). The hepatic expression level is up-regulated in obese mice compared to lean animals (PubMed:21987372). Up-regulated by endocannabinoid anandamide/AEA (PubMed:21987372, PubMed:23955712). Down-regulated by IL1B (PubMed:23955712). Up-regulated in the liver of animals on a high-fat diet compared to regular diet (PubMed:15864349, PubMed:21987372). Palmitoylation at Cys-416 is important for recruitment at both plasma membrane and lipid rafts and association with G protein alpha subunits. Note=May contribute to the development of diet-induced obesity and several obesity-associated features, such as dyslipidemia and liver steatosis, regulating peripheral lipogenesis, energy expenditure and feeding behavior. In the liver, mediates cannabinoid-induced de novo lipogenesis and reduces fatty acid catabolism (PubMed:15864349, PubMed:21987372). In muscles, affects energy expenditure through mitochondrial metabolism (PubMed:22841573, PubMed:26671069). Induces leptin production by adipocytes and reduces LRP2-mediated leptin clearance in the kidney. The resulting hyperleptinemia causes resistance to the anorexic and weight-reducing effects of leptin (PubMed:22841573). In response to cannabinoids, drives the release of orexigenic beta-endorphin from hypothalamic POMC neurons, hence promoting food intake (PubMed:25707796). The use of peripherally- restricted inverse agonists in diet-induced obese mice reduces appetite, body weight, hepatic steatosis, and insulin resistance (PubMed:22841573). No visible phenotype, although mutant mice present a mild impairment in the adaptation to new environment. Mutant mice do not respond to cannabinoids, such as anandamide. The acute effects of opiates are not affected, but the reinforcing properties of morphine and the severity of the withdrawal syndrome are strongly reduced (PubMed:9888857). On high-fat diet, mutant mice remain lean, their metabolic and hormonal profile are unchanged, and they do not develop fatty liver, despite having caloric intake similar to that of wild-type mice (PubMed:15864349). High-fat diet also increases the hepatic levels of CNR1 ligand anandamide, but not that of 2-arachidonoylglycerol. Belongs to the G-protein coupled receptor 1 family. positive regulation of acute inflammatory response to antigenic stimulus G-protein coupled receptor activity cannabinoid receptor activity mitochondrion mitochondrial outer membrane plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway spermatogenesis axonal fasciculation aging response to nutrient learning or memory memory drug binding positive regulation of neuron projection development membrane integral component of membrane regulation of lipid metabolic process sensory perception of pain axon growth cone positive regulation of fever generation negative regulation of fatty acid beta-oxidation regulation of synaptic transmission, GABAergic response to lipopolysaccharide integral component of mitochondrial membrane negative regulation of mast cell activation negative regulation of dopamine secretion response to nicotine cannabinoid signaling pathway response to cocaine glucose homeostasis presynaptic membrane cell projection positive regulation of apoptotic process intracellular membrane-bounded organelle negative regulation of ion transport response to morphine membrane raft response to ethanol negative regulation of action potential negative regulation of blood pressure positive regulation of blood pressure regulation of insulin secretion negative regulation of nitric-oxide synthase activity regulation of synaptic transmission, glutamatergic maternal process involved in female pregnancy regulation of feeding behavior regulation of penile erection presynapse retrograde trans-synaptic signaling by endocannabinoid glutamatergic synapse GABA-ergic synapse integral component of presynaptic membrane positive regulation of presynaptic cytosolic calcium concentration trans-synaptic signaling by endocannabinoid, modulating synaptic transmission voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration uc008sfw.1 uc008sfw.2 
ENSMUST00000057190.4 Pabpc6 ENSMUST00000057190.4 poly(A) binding protein, cytoplasmic 6 (from RefSeq NM_001163836.1) ENSMUST00000057190.1 ENSMUST00000057190.2 ENSMUST00000057190.3 NM_001163836 Pabpc3 Pabpc6 Q9D4E6 Q9D4E6_MOUSE uc008ajy.1 uc008ajy.2 uc008ajy.3 uc008ajy.4 Binds the poly(A) tail of mRNA. Cytoplasm Nucleus Belongs to the polyadenylate-binding protein type-1 family. nucleic acid binding RNA binding mRNA 3'-UTR binding nucleus cytoplasm cytosol poly(A) binding biological_process poly(U) RNA binding cytoplasmic stress granule ribonucleoprotein complex uc008ajy.1 uc008ajy.2 uc008ajy.3 uc008ajy.4 
ENSMUST00000057194.9 Lrrc75a ENSMUST00000057194.9 leucine rich repeat containing 75A, transcript variant 1 (from RefSeq NM_198861.1) ENSMUST00000057194.1 ENSMUST00000057194.2 ENSMUST00000057194.3 ENSMUST00000057194.4 ENSMUST00000057194.5 ENSMUST00000057194.6 ENSMUST00000057194.7 ENSMUST00000057194.8 Fam211a LR75A_MOUSE NM_198861 Q3UIX7 Q7TSF4 Q811G5 uc007jjo.1 uc007jjo.2 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TSF4-1; Sequence=Displayed; Name=2; IsoId=Q7TSF4-2; Sequence=VSP_025136; Belongs to the LRRC75 family. molecular_function cytoplasm biological_process uc007jjo.1 uc007jjo.2 
ENSMUST00000057195.17 Nup62 ENSMUST00000057195.17 nucleoporin 62 (from RefSeq NM_053074.2) ENSMUST00000057195.1 ENSMUST00000057195.10 ENSMUST00000057195.11 ENSMUST00000057195.12 ENSMUST00000057195.13 ENSMUST00000057195.14 ENSMUST00000057195.15 ENSMUST00000057195.16 ENSMUST00000057195.2 ENSMUST00000057195.3 ENSMUST00000057195.4 ENSMUST00000057195.5 ENSMUST00000057195.6 ENSMUST00000057195.7 ENSMUST00000057195.8 ENSMUST00000057195.9 NM_053074 NUP62_MOUSE Q63850 Q99JN7 uc009gqw.1 uc009gqw.2 uc009gqw.3 uc009gqw.4 uc009gqw.5 Essential component of the nuclear pore complex. The N- terminal is probably involved in nucleocytoplasmic transport. The C- terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown. Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58. Interacts with NUP88. Interacts with NUTF2. Interacts with HIKESHI. Interacts with OSBPL8. Interacts with CAPG. Interacts with SAS6 and TUBG1 at the centrosome. Interacts with MCM3AP (By similarity). Nucleus, nuclear pore complex Cytoplasm, cytoskeleton, spindle pole Nucleus envelope Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle. Contains FG repeats. O-glycosylated. The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC. Belongs to the nucleoporin NSP1/NUP62 family. mitotic cell cycle spindle pole protein binding phospholipid binding nucleus nuclear envelope annulate lamellae nuclear pore cytoplasm centrosome microtubule organizing center cytoskeleton transcription, DNA-templated protein import into nucleus mitotic metaphase plate congression centrosome cycle mitotic centrosome separation cell surface receptor signaling pathway spermatogenesis cell aging cell death negative regulation of cell proliferation protein transport cell migration structural constituent of nuclear pore kinesin binding receptor signaling complex scaffold activity Hsp70 protein binding nuclear membrane macromolecular complex negative regulation of epidermal growth factor receptor signaling pathway SH2 domain binding regulation of protein import into nucleus negative regulation of apoptotic process negative regulation of programmed cell death positive regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding negative regulation of MAP kinase activity nuclear pore central transport channel positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated negative regulation of Ras protein signal transduction positive regulation of centriole replication thyroid hormone receptor binding mRNA transport nuclear transport PTB domain binding Hsp90 protein binding regulation of mitotic spindle organization protein heterotrimerization mitotic spindle Flemming body centriole assembly positive regulation of mitotic cytokinetic process positive regulation of protein localization to centrosome ribonucleoprotein complex uc009gqw.1 uc009gqw.2 uc009gqw.3 uc009gqw.4 uc009gqw.5 
ENSMUST00000057208.13 Mrps9 ENSMUST00000057208.13 mitochondrial ribosomal protein S9 (from RefSeq NM_023514.4) ENSMUST00000057208.1 ENSMUST00000057208.10 ENSMUST00000057208.11 ENSMUST00000057208.12 ENSMUST00000057208.2 ENSMUST00000057208.3 ENSMUST00000057208.4 ENSMUST00000057208.5 ENSMUST00000057208.6 ENSMUST00000057208.7 ENSMUST00000057208.8 ENSMUST00000057208.9 NM_023514 Q14AZ3 Q6IS29 Q80W17 Q9D7N3 RT09_MOUSE uc007ava.1 uc007ava.2 uc007ava.3 uc007ava.4 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uS9 family. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA binding structural constituent of ribosome nucleolus mitochondrion mitochondrial small ribosomal subunit ribosome translation uc007ava.1 uc007ava.2 uc007ava.3 uc007ava.4 
ENSMUST00000057224.4 Ccdc187 ENSMUST00000057224.4 coiled-coil domain containing 187 (from RefSeq NM_177841.3) CC187_MOUSE Ccdc187 ENSMUST00000057224.1 ENSMUST00000057224.2 ENSMUST00000057224.3 NM_177841 Q8C5V8 uc008ium.1 uc008ium.2 uc008ium.3 molecular_function centrosome microtubule binding biological_process microtubule anchoring uc008ium.1 uc008ium.2 uc008ium.3 
ENSMUST00000057228.2 Pcdhb9 ENSMUST00000057228.2 protocadherin beta 9 (from RefSeq NM_053134.3) E9Q5G2 E9Q5G2_MOUSE ENSMUST00000057228.1 NM_053134 Pcdhb9 uc008epu.1 uc008epu.2 calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epu.1 uc008epu.2 
ENSMUST00000057236.5 Dnajb7 ENSMUST00000057236.5 DnaJ heat shock protein family (Hsp40) member B7 (from RefSeq NM_021317.2) DNJB7_MOUSE ENSMUST00000057236.1 ENSMUST00000057236.2 ENSMUST00000057236.3 ENSMUST00000057236.4 NM_021317 Q9DA41 Q9QYI8 uc007wwp.1 uc007wwp.2 uc007wwp.3 Probably acts as a co-chaperone. Sequence=BAA88303.1; Type=Frameshift; Evidence=; cellular_component biological_process chaperone binding uc007wwp.1 uc007wwp.2 uc007wwp.3 
ENSMUST00000057243.6 Tmem252 ENSMUST00000057243.6 transmembrane protein 252 (from RefSeq NM_183160.3) ENSMUST00000057243.1 ENSMUST00000057243.2 ENSMUST00000057243.3 ENSMUST00000057243.4 ENSMUST00000057243.5 NM_183160 Q3UP68 Q8C353 TM252_MOUSE uc008har.1 uc008har.2 uc008har.3 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc008har.1 uc008har.2 uc008har.3 
ENSMUST00000057251.8 Or2r2 ENSMUST00000057251.8 olfactory receptor family 2 subfamily R member 2 (from RefSeq NM_001011528.2) B2RT27 B2RT27_MOUSE ENSMUST00000057251.1 ENSMUST00000057251.2 ENSMUST00000057251.3 ENSMUST00000057251.4 ENSMUST00000057251.5 ENSMUST00000057251.6 ENSMUST00000057251.7 NM_001011528 Olfr456 Or2r2 uc009brk.1 uc009brk.2 uc009brk.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC139108.1, BC139109.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009brk.1 uc009brk.2 uc009brk.3 
ENSMUST00000057254.6 Ubqln3 ENSMUST00000057254.6 ubiquilin 3, transcript variant 2 (from RefSeq NM_198623.3) ENSMUST00000057254.1 ENSMUST00000057254.2 ENSMUST00000057254.3 ENSMUST00000057254.4 ENSMUST00000057254.5 NM_198623 Q8C5U9 UBQL3_MOUSE uc009ivk.1 uc009ivk.2 uc009ivk.3 Testis-specific (at protein level). cytosol ubiquitin-dependent protein catabolic process polyubiquitin binding uc009ivk.1 uc009ivk.2 uc009ivk.3 
ENSMUST00000057256.5 6030458C11Rik ENSMUST00000057256.5 RIKEN cDNA 6030458C11 gene, transcript variant 2 (from RefSeq NM_029998.4) B2RQ49 CE022_MOUSE ENSMUST00000057256.1 ENSMUST00000057256.2 ENSMUST00000057256.3 ENSMUST00000057256.4 NM_029998 Q8BGC1 Q8BYV3 Q8BZ46 Q9CX64 uc007vhw.1 uc007vhw.2 uc007vhw.3 uc007vhw.4 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BGC1-1; Sequence=Displayed; Name=2; IsoId=Q8BGC1-2; Sequence=VSP_028185; Name=3; IsoId=Q8BGC1-3; Sequence=VSP_028186; Belongs to the UPF0489 family. molecular_function cellular_component biological_process uc007vhw.1 uc007vhw.2 uc007vhw.3 uc007vhw.4 
ENSMUST00000057257.10 Jkamp ENSMUST00000057257.10 JNK1/MAPK8-associated membrane protein, transcript variant 1 (from RefSeq NM_024205.2) B8JJ79 B8JJ80 ENSMUST00000057257.1 ENSMUST00000057257.2 ENSMUST00000057257.3 ENSMUST00000057257.4 ENSMUST00000057257.5 ENSMUST00000057257.6 ENSMUST00000057257.7 ENSMUST00000057257.8 ENSMUST00000057257.9 JKAMP_MOUSE Jamp NM_024205 Q8BI36 Q99LT2 Q9CUZ1 uc007nvf.1 uc007nvf.2 uc007nvf.3 uc007nvf.4 Regulates the duration of MAPK8 activity in response to various stress stimuli (PubMed:16166642). Facilitates degradation of misfolded endoplasmic reticulum (ER) proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (PubMed:18784250). Interacts with RNF5 and MAPK8, but not with MAPK9. Binding to MAPK8 occurs before and after exposure to stress, such as UV irradiation. After exposure to stress, interacts with phosphorylated MAPK8. Competes with DUSP10 for MAPK8 binding (PubMed:16166642, PubMed:19269966). Associates with multiple components of the proteasome and with ERAD regulatory proteins, including AMFR/GP78, CANX, PSMC1, PSMC2, PSMC3/TBP1, PSMC5, PSMC6, PSMD8, SEC61-ALPHA and UFD1 (PubMed:18784250). Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BI36-1; Sequence=Displayed; Name=2; IsoId=Q8BI36-2; Sequence=VSP_008813; Expressed in numerous tissues, including brain, spleen, thymus, liver, kidney and testis. Ubiquitinated by RNF5 via 'Lys-63'-linked ubiquitin linkage in a UBE2N-dependent manner. Ubiquitination decreases association with components of the proteasome and ERAD. cellular_component endoplasmic reticulum endoplasmic reticulum membrane response to unfolded protein membrane integral component of membrane ER-associated ubiquitin-dependent protein catabolic process ubiquitin protein ligase binding uc007nvf.1 uc007nvf.2 uc007nvf.3 uc007nvf.4 
ENSMUST00000057262.8 Kcne4 ENSMUST00000057262.8 potassium voltage-gated channel, Isk-related subfamily, gene 4 (from RefSeq NM_021342.2) ENSMUST00000057262.1 ENSMUST00000057262.2 ENSMUST00000057262.3 ENSMUST00000057262.4 ENSMUST00000057262.5 ENSMUST00000057262.6 ENSMUST00000057262.7 KCNE4_MOUSE Kcne4 NM_021342 Q9WTW3 uc007bqq.1 uc007bqq.2 uc007bqq.3 uc007bqq.4 Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associates with KCNQ1/KVLTQ1 and inhibits potassium currents. May also inhibit KCNQ4-mediated potassium currents. Interacts with KCNQ1; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity. Membrane ; Single- pass membrane protein Belongs to the potassium channel KCNE family. voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity ion transport potassium ion transport voltage-gated potassium channel complex potassium channel regulator activity membrane integral component of membrane apical plasma membrane regulation of ion transmembrane transport ion channel binding regulation of ventricular cardiac muscle cell membrane repolarization potassium ion transmembrane transport ventricular cardiac muscle cell action potential membrane repolarization during action potential regulation of heart rate by cardiac conduction potassium ion export across plasma membrane membrane repolarization during ventricular cardiac muscle cell action potential negative regulation of delayed rectifier potassium channel activity delayed rectifier potassium channel activity voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization uc007bqq.1 uc007bqq.2 uc007bqq.3 uc007bqq.4 
ENSMUST00000057265.8 BC048562 ENSMUST00000057265.8 cDNA sequence BC048562 (from RefSeq NM_001004192.2) BC048562 ENSMUST00000057265.1 ENSMUST00000057265.2 ENSMUST00000057265.3 ENSMUST00000057265.4 ENSMUST00000057265.5 ENSMUST00000057265.6 ENSMUST00000057265.7 NM_001004192 Q80ZQ7 Q80ZQ7_MOUSE uc009rpm.1 uc009rpm.2 uc009rpm.3 molecular_function cellular_component biological_process uc009rpm.1 uc009rpm.2 uc009rpm.3 
ENSMUST00000057270.9 Pnlip ENSMUST00000057270.9 pancreatic lipase (from RefSeq NM_026925.4) ENSMUST00000057270.1 ENSMUST00000057270.2 ENSMUST00000057270.3 ENSMUST00000057270.4 ENSMUST00000057270.5 ENSMUST00000057270.6 ENSMUST00000057270.7 ENSMUST00000057270.8 LIPP_MOUSE NM_026925 Pnlip Q6P8U6 uc008iaq.1 uc008iaq.2 uc008iaq.3 uc008iaq.4 Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones. Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12045; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + di-(9Z)-octadecenoylglycerol + H(+); Xref=Rhea:RHEA:38575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38576; Evidence=; Reaction=1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+); Xref=Rhea:RHEA:40475, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:35020, ChEBI:CHEBI:76478; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40476; Evidence=; Reaction=all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate; Xref=Rhea:RHEA:13933, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13934; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38455, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52323, ChEBI:CHEBI:75937; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38456; Evidence=; Inhibited by bile salts, is reactivated by (pro)colipase/CLPS. Forms a 1:1 stoichiometric complex with (pro)colipase/CLPS. Secreted Pancreas. Belongs to the AB hydrolase superfamily. Lipase family. triglyceride lipase activity extracellular region extracellular space lipid metabolic process post-embryonic development lipid catabolic process lipase activity hydrolase activity intestinal cholesterol absorption metal ion binding carboxylic ester hydrolase activity positive regulation of triglyceride lipase activity uc008iaq.1 uc008iaq.2 uc008iaq.3 uc008iaq.4 
ENSMUST00000057272.15 Bltp1 ENSMUST00000057272.15 bridge-like lipid transfer protein family member 1 (from RefSeq NM_172679.2) A2AAD2 A2AAD4 A2AAE1 BLTP1_MOUSE E9Q376 ENSMUST00000057272.1 ENSMUST00000057272.10 ENSMUST00000057272.11 ENSMUST00000057272.12 ENSMUST00000057272.13 ENSMUST00000057272.14 ENSMUST00000057272.2 ENSMUST00000057272.3 ENSMUST00000057272.4 ENSMUST00000057272.5 ENSMUST00000057272.6 ENSMUST00000057272.7 ENSMUST00000057272.8 ENSMUST00000057272.9 Fsa Kiaa1109 Kiaa1371 NM_172679 Q05BP8 Q3UG08 Q3UYB7 Q571C4 Q69ZR8 Q6AXD9 Q8BWF1 Q8BY77 Q8CEA4 Q8R0A8 uc008pab.1 uc008pab.2 uc008pab.3 Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum. Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics. Acts as a regulator of phagocytosis. Cell membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Mitochondrion membrane ; Single-pass membrane protein Note=Localizes to endoplasmic reticulum-cell membrane and some endoplasmic reticulum- mitochondria contact sites. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=A2AAE1-1; Sequence=Displayed; Name=2; IsoId=A2AAE1-2; Sequence=VSP_031037; Name=3; IsoId=A2AAE1-3; Sequence=VSP_031036, VSP_031037, VSP_031038; Name=4; IsoId=A2AAE1-4; Sequence=VSP_031032, VSP_031033; Name=5; IsoId=A2AAE1-5; Sequence=VSP_031034, VSP_031035; Name=6; IsoId=A2AAE1-6; Sequence=VSP_031038; Highly expressed in testis and ovary. Weakly or not expressed in other tissues. Expressed during spermatogenesis and adipogenesis. Sequence=AAH27125.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH79623.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC31019.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC31019.1; Type=Frameshift; Evidence=; Sequence=BAC35104.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD90190.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAM28060.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM28069.1; Type=Erroneous gene model prediction; Evidence=; regulation of cell growth molecular_function nucleus lipid metabolic process spermatogenesis membrane integral component of membrane lipid storage fat cell differentiation synaptic vesicle endocytosis nucleus localization adipose tissue development presynapse uc008pab.1 uc008pab.2 uc008pab.3 
ENSMUST00000057279.6 Olfml2a ENSMUST00000057279.6 olfactomedin-like 2A (from RefSeq NM_172854.2) ENSMUST00000057279.1 ENSMUST00000057279.2 ENSMUST00000057279.3 ENSMUST00000057279.4 ENSMUST00000057279.5 NM_172854 OLM2A_MOUSE Q8BHP7 uc008jnv.1 uc008jnv.2 uc008jnv.3 Homodimer. Binds to heparin and chondroitin sulfate E. Secreted Expressed in lung, eye, testis, uterus, ovary, and to a lesser extent in heart, skeletal muscle, mammary gland, skin and prostate. Within the eye, mainly present in photoreceptor layers (at protein level). Seems to be cleaved at Lys-301 after secretion. O-glycosylated but not N-glycosylated. extracellular region extracellular matrix organization extracellular matrix protein homodimerization activity extracellular matrix binding uc008jnv.1 uc008jnv.2 uc008jnv.3 
ENSMUST00000057283.8 B4galnt3 ENSMUST00000057283.8 beta-1,4-N-acetyl-galactosaminyl transferase 3 (from RefSeq NM_198884.2) B4GN3_MOUSE ENSMUST00000057283.1 ENSMUST00000057283.2 ENSMUST00000057283.3 ENSMUST00000057283.4 ENSMUST00000057283.5 ENSMUST00000057283.6 ENSMUST00000057283.7 NM_198884 Q6L8S8 uc009dmy.1 uc009dmy.2 uc009dmy.3 Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'- diacetyllactosediamine formation on gastric mucosa (By similarity). Reaction=an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl- alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N- acetyl-beta-D-glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:20493, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:61631, ChEBI:CHEBI:67138, ChEBI:CHEBI:138027; EC=2.4.1.244; Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Note=Localizes to apical Golgi. Belongs to the chondroitin N- acetylgalactosaminyltransferase family. Name=Functional Glycomics Gateway - GTase; Note=Beta1,4- N-acetylgalactosaminyltransferase III; URL="http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=gt_mou_507"; Golgi apparatus acetylgalactosaminyltransferase activity membrane integral component of membrane transferase activity Golgi cisterna membrane N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity uc009dmy.1 uc009dmy.2 uc009dmy.3 
ENSMUST00000057288.8 Pdia6 ENSMUST00000057288.8 Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; Evidence=; (from UniProt F7DBQ0) AK076558 ENSMUST00000057288.1 ENSMUST00000057288.2 ENSMUST00000057288.3 ENSMUST00000057288.4 ENSMUST00000057288.5 ENSMUST00000057288.6 ENSMUST00000057288.7 F7DBQ0 F7DBQ0_MOUSE Pdia6 uc007ncp.1 uc007ncp.2 uc007ncp.3 uc007ncp.4 Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; Evidence=; Endoplasmic reticulum lumen Melanosome Belongs to the protein disulfide isomerase family. uc007ncp.1 uc007ncp.2 uc007ncp.3 uc007ncp.4 
ENSMUST00000057293.8 Prr12 ENSMUST00000057293.8 proline rich 12 (from RefSeq NM_175022.3) E9PYL2 ENSMUST00000057293.1 ENSMUST00000057293.2 ENSMUST00000057293.3 ENSMUST00000057293.4 ENSMUST00000057293.5 ENSMUST00000057293.6 ENSMUST00000057293.7 Kiaa1205 NM_175022 PRR12_MOUSE Prr12 Q69ZN8 uc009gsu.1 uc009gsu.2 uc009gsu.3 Nucleus Postsynaptic density Synapse, synaptosome Note=A smaller form of approximately 150 kDa has been found in perisynapse, synaptosomes and postsynaptic density in 15 dpc, P1 and adult brains. Expressed in brain. Strongest expression found in embryonic day 15 dpc compared to postnatal day P1 and adult brain. molecular_function DNA binding cellular_component nucleus plasma membrane biological_process postsynaptic density membrane cell junction neuron projection synapse postsynaptic membrane uc009gsu.1 uc009gsu.2 uc009gsu.3 
ENSMUST00000057311.4 Sfn ENSMUST00000057311.4 stratifin (from RefSeq NM_018754.3) 1433S_MOUSE ENSMUST00000057311.1 ENSMUST00000057311.2 ENSMUST00000057311.3 Mkrn3 NM_018754 O70456 Q3TEZ1 uc008vdc.1 uc008vdc.2 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. Homodimer. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35. Interacts with GAB2 (By similarity). Interacts with KRT17. Interacts with SAMSN1. Interacts with SRPK2 (By similarity). Interacts with COPS6 (By similarity). Interacts with COP1; this interaction leads to proteasomal degradation (By similarity).Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB (By similarity). Interacts with SLITRK1 (By similarity). Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (By similarity). O70456; Q9QWL7: Krt17; NbExp=3; IntAct=EBI-1544118, EBI-309015; Cytoplasm Nucleus Secreted Note=May be secreted by a non-classical secretory pathway. Expressed in the basal layer of skin epithelium and in outer root sheath of hair follicle. Induced in damaged or stressed epidermis. Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation (By similarity). 14-3-3 proteins have been shown to be PKC activators, but this effect could be non-specific and only due to the acidic nature of the protein. Belongs to the 14-3-3 family. regulation of cyclin-dependent protein serine/threonine kinase activity release of cytochrome c from mitochondria keratinocyte development protein binding extracellular region nucleus cytoplasm cytosol intrinsic apoptotic signaling pathway in response to DNA damage regulation of epidermal cell division negative regulation of keratinocyte proliferation protein kinase binding protein domain specific binding keratinocyte differentiation positive regulation of cell growth keratinization identical protein binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process skin development positive regulation of epidermal cell differentiation positive regulation of protein export from nucleus phosphoprotein binding regulation of cell cycle establishment of skin barrier uc008vdc.1 uc008vdc.2 
ENSMUST00000057320.8 Tmc5 ENSMUST00000057320.8 transmembrane channel-like gene family 5, transcript variant 2 (from RefSeq NM_028930.3) ENSMUST00000057320.1 ENSMUST00000057320.2 ENSMUST00000057320.3 ENSMUST00000057320.4 ENSMUST00000057320.5 ENSMUST00000057320.6 ENSMUST00000057320.7 NM_028930 Q32NZ6 Q7TN61 Q80VR0 Q9D4F1 TMC5_MOUSE uc009jkg.1 uc009jkg.2 uc009jkg.3 uc009jkg.4 Probable ion channel. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q32NZ6-1; Sequence=Displayed; Name=2; IsoId=Q32NZ6-2; Sequence=VSP_026047, VSP_026048; Ubiquitously expressed. Belongs to the TMC family. ion channel activity integral component of plasma membrane ion transport mechanically-gated ion channel activity membrane integral component of membrane ion transmembrane transport transmembrane transport uc009jkg.1 uc009jkg.2 uc009jkg.3 uc009jkg.4 
ENSMUST00000057324.4 Flrt2 ENSMUST00000057324.4 fibronectin leucine rich transmembrane protein 2, transcript variant 2 (from RefSeq NM_201518.4) ENSMUST00000057324.1 ENSMUST00000057324.2 ENSMUST00000057324.3 FLRT2_MOUSE Flrt2 Kiaa0405 NM_201518 Q6A073 Q8BLU0 uc007olc.1 uc007olc.2 uc007olc.3 uc007olc.4 Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:21350012, PubMed:25728924, PubMed:25374360). May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D (PubMed:21673655). Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members (PubMed:21673655, PubMed:25728924). Plays a role in fibroblast growth factor-mediated signaling cascades (PubMed:16872596). Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis (PubMed:21350012). Self-associates (via leucine-rich repeats), giving rise to homooligomers (PubMed:25374360). Interacts with FGFR1 (PubMed:16872596). Interacts with FGFR2 (PubMed:21765038). Interacts (via extracellular domain) with ADGRL1/LPHN1 (PubMed:22405201). Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain)(PubMed:22405201, PubMed:25728924). Interacts (via extracellular domain) with UNC5D (via the first Ig-like domain) (PubMed:21673655, PubMed:25374360). Can also interact (via extracellular domain) with UNC5B, but with much lower affinity (PubMed:21673655). Interacts (via extracellular domain) with FN1 (PubMed:24585683). Q8BLU0; Q80TS3: Adgrl3; NbExp=2; IntAct=EBI-16146541, EBI-770665; Cell membrane ingle-pass membrane protein Endoplasmic reticulum membrane Cell junction, focal adhesion Secreted, extracellular space, extracellular matrix Synapse, synaptosome Microsome membrane Secreted Note=Proteolytic cleavage gives rise to a shedded ectodomain. Detected in adult brain (at protein level). Detected in embryonic brain at 13 dpc. Levels in brain decrease gradually after 15 dpc, but expression continues after birth (PubMed:21673655). Detected in embryonic myocardium, body wall and pro-epicardial organ at 9.5 dpc. Detected in the epicardial cell layer and throughout the myocardium at 10.5 dpc. Highly expressed in embryonic and neonate heart, but after that levels decrease strongly, and the protein is barely detectable 3 weeks after birth, with even lower levels after 7 and 15 weeks (at protein level) (PubMed:21350012). Detected in the anterior endoderm at 7.5 dpc. Detected on anterior somites, the allantois and mesenchymal tissue behind the developing heart at 8.5 dpc (PubMed:18448090). Detected in the cephalic mesenchyme and in tissue posterior to the developing heart at 9.5 and 10.5 dpc. Detected in the developing stomach and in a subset of the trunk sclerotome at 10.5 dpc. At 11 dpc, detected also in branchial arches, eyes and limbs (PubMed:16872596, PubMed:18448090). Up-regulated by FGF2. N-glycosylated. Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease. Heterozygous mice are viable and fertile, but homozygous mice display nearly complete embryonic lethality. Most embryos die at about 12.5 dpc, probably due to impaired expansion of the ventricular myocardium during development, reduced endocardial volume and heart insufficiency. Contrary to wild-type, the epicardium appears ruffled and presents numerous holes, due to defective formation of cell-cell adhesions. Still, there is a very small percentage of life-born pups that survive at least up to weaning. heart morphogenesis fibroblast growth factor receptor binding protein binding extracellular region extracellular space endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane cell-cell junction focal adhesion cell adhesion multicellular organism development axon guidance fibroblast growth factor receptor signaling pathway membrane integral component of membrane cell junction organelle membrane neuron projection intracellular membrane-bounded organelle synapse chemorepellent activity negative chemotaxis positive regulation of synapse assembly cell adhesion involved in heart morphogenesis basement membrane organization regulation of neuron migration uc007olc.1 uc007olc.2 uc007olc.3 uc007olc.4 
ENSMUST00000057325.15 Ccdc125 ENSMUST00000057325.15 coiled-coil domain containing 125, transcript variant A (from RefSeq NM_183115.5) CC125_MOUSE E9QPT5 ENSMUST00000057325.1 ENSMUST00000057325.10 ENSMUST00000057325.11 ENSMUST00000057325.12 ENSMUST00000057325.13 ENSMUST00000057325.14 ENSMUST00000057325.2 ENSMUST00000057325.3 ENSMUST00000057325.4 ENSMUST00000057325.5 ENSMUST00000057325.6 ENSMUST00000057325.7 ENSMUST00000057325.8 ENSMUST00000057325.9 Kenae NM_183115 Q5U465 Q8CEN7 uc007rrj.1 uc007rrj.2 uc007rrj.3 uc007rrj.4 May be involved in the regulation of cell migration. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5U465-1; Sequence=Displayed; Name=2; IsoId=Q5U465-2; Sequence=VSP_025782, VSP_026155, VSP_025783, VSP_025784; Expressed in many tissues, with highest levels in spleen, thymus and bone marrow. molecular_function cytoplasm negative regulation of Rho protein signal transduction activation of GTPase activity regulation of cell motility negative regulation of cell motility uc007rrj.1 uc007rrj.2 uc007rrj.3 uc007rrj.4 
ENSMUST00000057337.9 Fgfbp3 ENSMUST00000057337.9 Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability. (from UniProt Q1HCM0) BC055778 ENSMUST00000057337.1 ENSMUST00000057337.2 ENSMUST00000057337.3 ENSMUST00000057337.4 ENSMUST00000057337.5 ENSMUST00000057337.6 ENSMUST00000057337.7 ENSMUST00000057337.8 FGFP3_MOUSE Q1HCM0 Q7TNS6 Q8CDW7 uc008hhv.1 uc008hhv.2 uc008hhv.3 uc008hhv.4 Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability. Interacts with FGF2. Secreted In the adult, highly expressed in brain with lower levels in ovary. In the embryo, highest levels are found in the brain and spinal cord at 14 dpc and expression is almost completely restricted to the brain by 18 dpc. In the adult and postnatal brain, highly expressed in the orbitofrontal cortex where it is concentrated primarily in differentiated neurons. Expression is first detected at 10 dpc and reaches a peak at birth. After birth, levels decrease and remain constant throughout postnatal development. Mutants display a range of anxiety-related behaviors including reduced time spent in the central area of the open- field arena, reduced activity in lit areas of a light/dark transition test and prolonged latency to feeding in a novelty induced hypophagia test which assesses the drive to drink a sweetened milk solution. Belongs to the fibroblast growth factor-binding protein family. Sequence=ABF56583.1; Type=Erroneous initiation; Evidence=; extracellular region cell-cell signaling heparin binding fibroblast growth factor binding growth factor binding adult behavior positive regulation of neurological system process positive regulation of vascular permeability positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of ERK1 and ERK2 cascade uc008hhv.1 uc008hhv.2 uc008hhv.3 uc008hhv.4 
ENSMUST00000057344.3 Pkd1l3 ENSMUST00000057344.3 polycystic kidney disease 1 like 3, transcript variant 2 (from RefSeq NM_181544.3) 71B10 E9QPA5 ENSMUST00000057344.1 ENSMUST00000057344.2 NM_181544 PK1L3_MOUSE Q2EG93 Q2EG94 Q2EG95 Q2EG96 Q2EG97 Q2EG98 Q2EG99 Q7TN87 uc009nit.1 uc009nit.2 Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. The calcium channel is gated following an off- response property by acid: gated open after the removal of acid stimulus, but not during acid application. Calcium channels are probably composed of 3 subunit of PKD2L1 and 1 subunit of PKD1L3. Q2EG98; A2A259: Pkd2l1; NbExp=2; IntAct=EBI-15594779, EBI-15594711; Cell membrane ulti-pass membrane protein Note=Interaction with PKD2L1 is required for localization to the cell membrane. Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=Variant 1a; IsoId=Q2EG98-1; Sequence=Displayed; Name=2; Synonyms=Variant 1b; IsoId=Q2EG98-2; Sequence=VSP_031953, VSP_031954; Name=3; Synonyms=Variant 2; IsoId=Q2EG98-3; Sequence=VSP_031961; Name=4; Synonyms=Variant 3; IsoId=Q2EG98-4; Sequence=VSP_031962; Name=5; Synonyms=Variant 4; IsoId=Q2EG98-5; Sequence=VSP_031959; Name=6; Synonyms=Variant 5; IsoId=Q2EG98-6; Sequence=VSP_031952, VSP_031953, VSP_031954, VSP_031955, VSP_031958; Name=7; Synonyms=Variant 6; IsoId=Q2EG98-7; Sequence=VSP_031956, VSP_031957; Name=8; IsoId=Q2EG98-8; Sequence=VSP_031953, VSP_031954, VSP_031960; Expressed in a subset of taste receptor cells distinct from those involved in bitter, sweet and umami taste. Expressed in circumvallate and foliate taste buds, but not in surrounding non-gustatory lingual epithelium cells. Expressed in testis. No significant reduction in taste responsiveness: mice have normal nerve and behavioral responses to sour stimuli. Belongs to the polycystin family. Pkd1l3 and Pkd2l1 have been identified as sour taste receptor in gustatory cells based on a number of indirect evidences: Pkd2l1 is expressed in circumvallate papillae cells on the posterior part of the tongue distinct from those responsible for sweet, bitter and unami taste and genetic elimination of cells expressing Pkd2l1 reduces gustatory nerve responses to sour taste stimuli (PubMed:16891422, PubMed:16929298). However, a number of experiments have recently shown that the sour taste receptor activity is probably indirect: mice lacking Pkd1l3 do not show defects in sour taste perception (PubMed:20605874, PubMed:21625513). Moreover, the Pkd1l3-Pkd2l1 heteromer, when expressed in cells does not respond to acid stimuli used to evoke proton currents in taste cells (PubMed:21098668). detection of chemical stimulus involved in sensory perception of sour taste calcium channel activity calcium ion binding protein binding plasma membrane ion transport cation transport calcium ion transport membrane integral component of membrane carbohydrate binding ion transmembrane transport cation channel complex receptor complex sensory perception of sour taste detection of mechanical stimulus calcium ion transmembrane transport cellular response to acidic pH cation transmembrane transport cell surface cation channel activity cation transmembrane transporter activity sour taste receptor activity uc009nit.1 uc009nit.2 
ENSMUST00000057373.14 Rab11b ENSMUST00000057373.14 RAB11B, member RAS oncogene family (from RefSeq NM_008997.3) ENSMUST00000057373.1 ENSMUST00000057373.10 ENSMUST00000057373.11 ENSMUST00000057373.12 ENSMUST00000057373.13 ENSMUST00000057373.2 ENSMUST00000057373.3 ENSMUST00000057373.4 ENSMUST00000057373.5 ENSMUST00000057373.6 ENSMUST00000057373.7 ENSMUST00000057373.8 ENSMUST00000057373.9 NM_008997 Q78ZJ8 Q78ZJ8_MOUSE RAB11B Rab11B Rab11b uc008bzm.1 uc008bzm.2 uc008bzm.3 Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Lipid-anchor ; Cytoplasmic side Endosome membrane ; Lipid-anchor ; Cytoplasmic side Membrane ; Lipid-anchor ; Cytoplasmic side Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding synaptic vesicle GDP binding cytoplasmic vesicle myosin V binding regulation of anion transport constitutive secretory pathway regulated exocytosis phagocytic vesicle cellular response to acidic pH establishment of protein localization to membrane anchored component of synaptic vesicle membrane retrograde transport, endosome to plasma membrane regulation of protein localization to cell surface uc008bzm.1 uc008bzm.2 uc008bzm.3 
ENSMUST00000057398.4 Tas2r143 ENSMUST00000057398.4 taste receptor, type 2, member 143 (from RefSeq NM_001001452.1) A7MAX5 ENSMUST00000057398.1 ENSMUST00000057398.2 ENSMUST00000057398.3 NM_001001452 Q2NL43 Q7TQB9 T2r36 TR143_MOUSE Tas2r43 uc009brf.1 uc009brf.2 Putative taste receptor which may play a role in the perception of bitterness. Membrane; Multi-pass membrane protein. Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway taste receptor activity membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009brf.1 uc009brf.2 
ENSMUST00000057405.9 Pcare ENSMUST00000057405.9 photoreceptor cilium actin regulator, transcript variant 1 (from RefSeq NM_146082.5) ENSMUST00000057405.1 ENSMUST00000057405.2 ENSMUST00000057405.3 ENSMUST00000057405.4 ENSMUST00000057405.5 ENSMUST00000057405.6 ENSMUST00000057405.7 ENSMUST00000057405.8 NM_146082 PCARE_MOUSE Pcare Q6PAC4 Q8BXR7 Q8R0C5 uc008dmv.1 uc008dmv.2 uc008dmv.3 Plays an essential role for normal photoreceptor cell maintenance and vision. Cell projection, cilium, photoreceptor outer segment Photoreceptor inner segment Specifically expressed in retina. Expressed in the developing eye at 14 dpc. Deficient mice develop severe early-onset retinal degeneration associated with a disorganized outer segment, progressive thinning of the outer nuclear layer, microglia activation and non- responsive to light by 8 weeks of age. Sequence=AAH27072.1; Type=Erroneous initiation; Evidence=; Sequence=BAC31912.1; Type=Erroneous initiation; Evidence=; photoreceptor outer segment photoreceptor inner segment molecular_function cilium visual perception photoreceptor cell outer segment organization cell projection response to stimulus detection of light stimulus involved in visual perception protein localization to photoreceptor outer segment uc008dmv.1 uc008dmv.2 uc008dmv.3 
ENSMUST00000057407.3 Qrfp ENSMUST00000057407.3 pyroglutamylated RFamide peptide (from RefSeq NM_183424.4) A2AV24 ENSMUST00000057407.1 ENSMUST00000057407.2 NM_183424 OX26_MOUSE Q8CE23 Qrfp uc008jed.1 uc008jed.2 uc008jed.3 uc008jed.4 This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides QRFP-26 (26RFa) and the N-terminally extended form, QRFP-43 (43RFa). Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK029144.1, BB613620.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Stimulates feeding and grooming behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland. Ligand for the G-protein coupled receptor QRFPR/GPR103. Secreted. Expressed in the brain with highest levels in the periventricular hypothalamic nucleus and lateral hypothalamic areas. Expressed at moderate levels in the adrenal gland, eye, heart, intestine, liver, lung, kidney, mesenteric lymph node, ovary, placenta, Peyer patches, skin, spleen, stomach, testis, thymus and uterus. Belongs to the RFamide neuropeptide family. G-protein coupled receptor binding neuropeptide hormone activity cellular_component extracellular region neuropeptide signaling pathway grooming behavior locomotory behavior orexigenic neuropeptide QRFP receptor binding positive regulation of blood pressure regulation of feeding behavior uc008jed.1 uc008jed.2 uc008jed.3 uc008jed.4 
ENSMUST00000057410.14 Fbln1 ENSMUST00000057410.14 fibulin 1, transcript variant 1 (from RefSeq NM_010180.2) ENSMUST00000057410.1 ENSMUST00000057410.10 ENSMUST00000057410.11 ENSMUST00000057410.12 ENSMUST00000057410.13 ENSMUST00000057410.2 ENSMUST00000057410.3 ENSMUST00000057410.4 ENSMUST00000057410.5 ENSMUST00000057410.6 ENSMUST00000057410.7 ENSMUST00000057410.8 ENSMUST00000057410.9 FBLN1_MOUSE NM_010180 Q08878 Q08879 Q8C3B1 Q91ZC9 Q922K8 uc011zxk.1 uc011zxk.2 uc011zxk.3 Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LMA2, NID, ACAN, CSPG2 and type IV collagen. Binding analysis demonstrated for isoform C a 100-fold stronger binding to the basement membrane protein NID than for isoform D. Interacts with FBLN7. Interacts with CCN3 (By similarity). Secreted, extracellular space, extracellular matrix. Event=Alternative splicing; Named isoforms=4; Name=D; IsoId=Q08879-1; Sequence=Displayed; Name=A; IsoId=Q08879-3; Sequence=Not described; Name=B; IsoId=Q08879-4; Sequence=Not described; Name=C; IsoId=Q08879-2; Sequence=VSP_001386; Detected in most organs (brain, heart, lung, spleen, liver and kidney). Neurons are the predominant source of production in the brain. Not expressed significantly by astrocytes or microglia. The differential expression of the fibulin family contributes to the formation of molecularly distinct extracellular matrices already during early developmental stages of a large number of tissues. Increased expression at neonate stage in the brain. Expressed in interdigital regions of the handplate of a 12 dpc embryo and in the lateral perichondrial region. Similar expression persists in the 13 dpc handplate particularly in the perichondrial regions and apical aspects of the developing digits. Glucocorticoids suppressed mRNA expression and protein synthesis. Belongs to the fibulin family. negative regulation of protein phosphorylation fibronectin binding integrin binding extracellular matrix structural constituent calcium ion binding protein binding extracellular region basement membrane extracellular space negative regulation of cell adhesion embryo implantation protein C-terminus binding positive regulation of gene expression positive regulation of peptidase activity peptidase activator activity extracellular matrix organization extracellular matrix identical protein binding macromolecular complex binding positive regulation of fibroblast proliferation fibrinogen binding negative regulation of ERK1 and ERK2 cascade elastic fiber blood coagulation, fibrin clot formation negative regulation of substrate adhesion-dependent cell spreading negative regulation of transformation of host cell by virus positive regulation of substrate-dependent cell migration, cell attachment to substrate negative regulation of cell motility negative regulation of stem cell proliferation negative regulation of transforming growth factor-beta secretion uc011zxk.1 uc011zxk.2 uc011zxk.3 
ENSMUST00000057416.8 Lyset ENSMUST00000057416.8 lysosomal enzyme trafficking factor, transcript variant 1 (from RefSeq NM_177140.5) C14orf109 ENSMUST00000057416.1 ENSMUST00000057416.2 ENSMUST00000057416.3 ENSMUST00000057416.4 ENSMUST00000057416.5 ENSMUST00000057416.6 ENSMUST00000057416.7 LYSET_MOUSE NM_177140 Q8BH26 Tmem251 uc007oum.1 uc007oum.2 uc007oum.3 uc007oum.4 Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases (By similarity). Plays an essential function for cells that depend on lysosomal catabolism to generate nutrients (PubMed:36074821). Interacts with GNPTAB; this interaction is important for proper localization of GNPTAB in Golgi stacks. Interacts with MBTPS1. Golgi apparatus membrane ; Multi-pass membrane protein Note=Colocalizes with GNPTAB and GNPTG in Golgi apparatus cisternae. LYSET knockout mice display increased lysosomal enzyme serum levels and storage materials in lysosomes. In addition, LYSET KO embryonic fibroblasts are resistant to infection by EBOV glycoprotein (VSV-EBOV). Belongs to the LYSET family. molecular_function cellular_component biological_process membrane integral component of membrane uc007oum.1 uc007oum.2 uc007oum.3 uc007oum.4 
ENSMUST00000057423.6 Plpp7 ENSMUST00000057423.6 phospholipid phosphatase 7 (inactive), transcript variant 1 (from RefSeq NM_145521.4) ENSMUST00000057423.1 ENSMUST00000057423.2 ENSMUST00000057423.3 ENSMUST00000057423.4 ENSMUST00000057423.5 NM_145521 Net39 PLPP7_MOUSE Plpp7 Ppapdc3 Q91WB2 uc008jel.1 uc008jel.2 uc008jel.3 Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity. Knockdown in myoblasts strongly promotes differentiation, whereas overexpression represses myogenesis. Homo- and heterooligomer. Interacts with MTOR; controls MTOR- dependent IGF2 expression during myoblast differentiation. Nucleus envelope. Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein. Note=Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm. Highly expressed in heart and muscle. Up-regulated during myoblast differentiation. Belongs to the PA-phosphatase related phosphoesterase family. nucleus nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane negative regulation of myotube differentiation membrane integral component of membrane dephosphorylation lipid phosphatase activity uc008jel.1 uc008jel.2 uc008jel.3 
ENSMUST00000057427.11 Lrrc70 ENSMUST00000057427.11 Lrrc70 (from geneSymbol) AK088316 ENSMUST00000057427.1 ENSMUST00000057427.10 ENSMUST00000057427.2 ENSMUST00000057427.3 ENSMUST00000057427.4 ENSMUST00000057427.5 ENSMUST00000057427.6 ENSMUST00000057427.7 ENSMUST00000057427.8 ENSMUST00000057427.9 uc007rty.1 uc007rty.2 uc007rty.3 uc007rty.1 uc007rty.2 uc007rty.3 
ENSMUST00000057428.13 Mylk4 ENSMUST00000057428.13 Belongs to the protein kinase superfamily. (from UniProt F8WIP5) ENSMUST00000057428.1 ENSMUST00000057428.10 ENSMUST00000057428.11 ENSMUST00000057428.12 ENSMUST00000057428.2 ENSMUST00000057428.3 ENSMUST00000057428.4 ENSMUST00000057428.5 ENSMUST00000057428.6 ENSMUST00000057428.7 ENSMUST00000057428.8 ENSMUST00000057428.9 F8WIP5 F8WIP5_MOUSE Mylk4 uc011yya.1 uc011yya.2 uc011yya.3 uc011yya.4 Belongs to the protein kinase superfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation uc011yya.1 uc011yya.2 uc011yya.3 uc011yya.4 
ENSMUST00000057431.6 Lenep ENSMUST00000057431.6 lens epithelial protein (from RefSeq NM_020517.4) ENSMUST00000057431.1 ENSMUST00000057431.2 ENSMUST00000057431.3 ENSMUST00000057431.4 ENSMUST00000057431.5 LENEP_MOUSE Lep503 NM_020517 Q9WVB6 uc033huw.1 uc033huw.2 uc033huw.3 molecular_function cytoplasm multicellular organism development biological_process uc033huw.1 uc033huw.2 uc033huw.3 
ENSMUST00000057438.7 Vcpip1 ENSMUST00000057438.7 valosin containing protein (p97)/p47 complex interacting protein 1 (from RefSeq NM_173443.3) A0A0R4J0M9 A0A0R4J0M9_MOUSE ENSMUST00000057438.1 ENSMUST00000057438.2 ENSMUST00000057438.3 ENSMUST00000057438.4 ENSMUST00000057438.5 ENSMUST00000057438.6 NM_173443 Vcpip1 uc007ags.1 uc007ags.2 uc007ags.3 uc007ags.4 This gene encodes a deubiquitinating enzyme that interacts with valosin containing protein p97 and plays a role in the assembly of Golgi apparatus during mitosis. [provided by RefSeq, Dec 2014]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC059209.1, SRR1660819.190611.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; mitotic cell cycle thiol-dependent ubiquitin-specific protease activity cytoplasm Golgi organization endoplasmic reticulum membrane fusion protein ubiquitination protein K11-linked deubiquitination protein K48-linked deubiquitination Golgi reassembly uc007ags.1 uc007ags.2 uc007ags.3 uc007ags.4 
ENSMUST00000057442.8 Diras2 ENSMUST00000057442.8 DIRAS family, GTP-binding RAS-like 2 (from RefSeq NM_001024474.2) DIRA2_MOUSE ENSMUST00000057442.1 ENSMUST00000057442.2 ENSMUST00000057442.3 ENSMUST00000057442.4 ENSMUST00000057442.5 ENSMUST00000057442.6 ENSMUST00000057442.7 NM_001024474 Q5PR73 uc007qmv.1 uc007qmv.2 uc007qmv.3 Displays low GTPase activity and exists predominantly in the GTP-bound form. Cell membrane ; Lipid-anchor ; Cytoplasmic side Belongs to the small GTPase superfamily. Di-Ras family. nucleotide binding GTPase activity GTP binding plasma membrane signal transduction biological_process membrane GDP binding uc007qmv.1 uc007qmv.2 uc007qmv.3 
ENSMUST00000057454.4 Gchfr ENSMUST00000057454.4 GTP cyclohydrolase I feedback regulator (from RefSeq NM_177157.4) ENSMUST00000057454.1 ENSMUST00000057454.2 ENSMUST00000057454.3 Gchfr NM_177157 Q4VAF4 Q4VAF4_MOUSE uc008ltf.1 uc008ltf.2 uc008ltf.3 Cytoplasm, cytosol Membrane Nucleus membrane Belongs to the GFRP family. enzyme inhibitor activity nucleus nucleoplasm cytoplasm negative regulation of biosynthetic process amino acid binding hydrolase activity enzyme binding dendrite GTP-dependent protein binding nuclear membrane macromolecular complex melanosome negative regulation of GTP cyclohydrolase I activity GTP cyclohydrolase binding protein heterooligomerization macromolecular complex assembly uc008ltf.1 uc008ltf.2 uc008ltf.3 
ENSMUST00000057465.7 A530016L24Rik ENSMUST00000057465.7 RIKEN cDNA A530016L24 gene (from RefSeq NM_177039.4) A0A0R4J0P8 A0A0R4J0P8_MOUSE A530016L24Rik ENSMUST00000057465.1 ENSMUST00000057465.2 ENSMUST00000057465.3 ENSMUST00000057465.4 ENSMUST00000057465.5 ENSMUST00000057465.6 NM_177039 uc007peq.1 uc007peq.2 uc007peq.3 membrane integral component of membrane uc007peq.1 uc007peq.2 uc007peq.3 
ENSMUST00000057481.7 Nup160 ENSMUST00000057481.7 nucleoporin 160, transcript variant 5 (from RefSeq NR_184761.1) ENSMUST00000057481.1 ENSMUST00000057481.2 ENSMUST00000057481.3 ENSMUST00000057481.4 ENSMUST00000057481.5 ENSMUST00000057481.6 Gtl1-13 Kiaa0197 NR_184761 NU160_MOUSE Q3TBI7 Q3TP11 Q3U250 Q6A0A7 Q7TME1 Q9CZD9 Q9Z0W3 uc008ksw.1 uc008ksw.2 Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Involved in poly(A)+ RNA transport (PubMed:11684705). Part of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Forms part of the NUP160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and NUP96 (PubMed:11564755, PubMed:11684705). This complex plays a role in RNA export and in tethering NUP98 and NUP153 to the nucleus (PubMed:11564755, PubMed:11684705). Nucleus, nuclear pore complex Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z0W3-1; Sequence=Displayed; Name=2; IsoId=Q9Z0W3-2; Sequence=VSP_018500, VSP_018501; kinetochore nucleus nuclear pore mRNA export from nucleus protein transport structural constituent of nuclear pore nuclear pore outer ring mRNA transport nephron development uc008ksw.1 uc008ksw.2 
ENSMUST00000057486.9 Ankrd46 ENSMUST00000057486.9 ankyrin repeat domain 46, transcript variant 3 (from RefSeq NM_175134.4) ANR46_MOUSE ENSMUST00000057486.1 ENSMUST00000057486.2 ENSMUST00000057486.3 ENSMUST00000057486.4 ENSMUST00000057486.5 ENSMUST00000057486.6 ENSMUST00000057486.7 ENSMUST00000057486.8 NM_175134 Q1LZK9 Q8BTZ5 Q8BV97 uc007vmt.1 uc007vmt.2 uc007vmt.3 uc007vmt.4 Membrane ; Single-pass membrane protein membrane integral component of membrane uc007vmt.1 uc007vmt.2 uc007vmt.3 uc007vmt.4 
ENSMUST00000057488.15 Cd200r1 ENSMUST00000057488.15 CD200 receptor 1 (from RefSeq NM_021325.4) ENSMUST00000057488.1 ENSMUST00000057488.10 ENSMUST00000057488.11 ENSMUST00000057488.12 ENSMUST00000057488.13 ENSMUST00000057488.14 ENSMUST00000057488.2 ENSMUST00000057488.3 ENSMUST00000057488.4 ENSMUST00000057488.5 ENSMUST00000057488.6 ENSMUST00000057488.7 ENSMUST00000057488.8 ENSMUST00000057488.9 MO2R1_MOUSE Mox2r NM_021325 Ox2r Q9ES57 uc007zhr.1 uc007zhr.2 uc007zhr.3 uc007zhr.4 Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro- inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. CD200 and CD200R1 interact via their respective N-terminal Ig- like domains. Q9ES57; O54901: Cd200; NbExp=3; IntAct=EBI-16045630, EBI-8328786; Cell membrane; Single-pass type I membrane protein. Expressed in granulocytes, monocytes, most T-cells and a subset of NK, NKT and B-cells (at protein level). Expressed in the spleen, lung, liver, testis, bone marrow, lymph nodes, spinal cord, kidney, uterus and small intestine. Expressed in mast and dendritic cells. Expressed in the lung of N. brasiliensis-infected mice. Belongs to the CD200R family. May be expressed in adult splenic cells (PubMed:15187158), as the antibody used could not discriminate between CD200R1 and CD200R4. May be expressed in uterus at 12.5 dpc (at protein level) (PubMed:15274657), as the antibody used could not discriminate between CD200R1 and CD200R4. protein binding plasma membrane external side of plasma membrane cell surface membrane integral component of membrane heterotypic cell-cell adhesion signaling receptor activity receptor complex protein binding involved in heterotypic cell-cell adhesion negative regulation of interleukin-6 secretion negative regulation of neuron death negative regulation of macrophage migration negative regulation of T cell migration uc007zhr.1 uc007zhr.2 uc007zhr.3 uc007zhr.4 
ENSMUST00000057495.10 Tmem161b ENSMUST00000057495.10 transmembrane protein 161B, transcript variant 1 (from RefSeq NM_175187.5) ENSMUST00000057495.1 ENSMUST00000057495.2 ENSMUST00000057495.3 ENSMUST00000057495.4 ENSMUST00000057495.5 ENSMUST00000057495.6 ENSMUST00000057495.7 ENSMUST00000057495.8 ENSMUST00000057495.9 NM_175187 Q8BT72 Q8C2L6 T161B_MOUSE uc007rip.1 uc007rip.2 uc007rip.3 uc007rip.4 Essential for maintaining normal cardiac rhythm in the developing heart and for neonatal survival (PubMed:33597309). Inhibits potassium and calcium currents in the cardiomyocytes, this assists in timely action potential repolarization and thereby maintains normal cardiac rhythm (PubMed:33597309). Cell membrane ; Multi-pass membrane protein Knockout mice are perinatal lethal and isolated embryonic cardiomyocytes exhibit arrhythmic calcium oscillations. Belongs to the TMEM161 family. molecular_function cellular_component membrane integral component of membrane uc007rip.1 uc007rip.2 uc007rip.3 uc007rip.4 
ENSMUST00000057497.13 Col26a1 ENSMUST00000057497.13 collagen, type XXVI, alpha 1, transcript variant 1 (from RefSeq NM_024474.3) COQA1_MOUSE Col26a ENSMUST00000057497.1 ENSMUST00000057497.10 ENSMUST00000057497.11 ENSMUST00000057497.12 ENSMUST00000057497.2 ENSMUST00000057497.3 ENSMUST00000057497.4 ENSMUST00000057497.5 ENSMUST00000057497.6 ENSMUST00000057497.7 ENSMUST00000057497.8 ENSMUST00000057497.9 Emid2 Emu2 NM_024474 Q8K4P3 Q91VF6 uc009aay.1 uc009aay.2 uc009aay.3 Homotrimer or heterotrimer. Secreted, extracellular space, extracellular matrix. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VF6-1; Sequence=Displayed; Name=2; IsoId=Q91VF6-2; Sequence=VSP_008448; Specifically expressed in the testis and ovary in adult tissues. At 9.5 dpc it is expressed in the somites and in mesenchymal cells of the head and the branchial arches. At 14.5 dpc it is expressed in the surrounding mesenchyme of the kidney and the inner ear. Expression is also observed in the spinal nerves and ganglia, the mesenchyme of the skull, the diaphragm, and the skeletal muscles. Hydroxylated on proline residues. N-glycosylated. [Isoform 2]: May be due to a competing acceptor splice site. protein binding extracellular region collagen trimer endoplasmic reticulum Golgi apparatus positive regulation of cell-substrate adhesion extracellular matrix uc009aay.1 uc009aay.2 uc009aay.3 
ENSMUST00000057500.6 Rnf7 ENSMUST00000057500.6 ring finger protein 7, transcript variant 1 (from RefSeq NM_011279.3) ENSMUST00000057500.1 ENSMUST00000057500.2 ENSMUST00000057500.3 ENSMUST00000057500.4 ENSMUST00000057500.5 NM_011279 Q3UKF8 Q9WTZ1 RBX2_MOUSE Rbx2 Sag uc009rcm.1 uc009rcm.2 uc009rcm.3 Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (By similarity). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents (By similarity). Protein modification; protein ubiquitination. Probable part of SCF complexes, which consist of SKP1, CUL1, RNF7/RBX2 and a F-box protein. Interacts (preferentially) with CUL5. Also interacts (with lower preference) with CUL1, CUL2, CUL3, CUL4A and CUL4B. Interacts with UBE2F (By similarity). May also interact with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5 (By similarity). Cytoplasm Nucleus The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion. Belongs to the RING-box family. protein binding nucleus nucleoplasm cytoplasm cytosol ubiquitin-dependent protein catabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process zinc ion binding intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic mitochondrial changes protein ubiquitination NEDD8 transferase activity cerebral cortex radially oriented cell migration radial glia guided migration of Purkinje cell SCF-dependent proteasomal ubiquitin-dependent protein catabolic process cullin-RING ubiquitin ligase complex Cul2-RING ubiquitin ligase complex Cul3-RING ubiquitin ligase complex Cul5-RING ubiquitin ligase complex Cul7-RING ubiquitin ligase complex negative regulation of apoptotic process nuclear SCF ubiquitin ligase complex protein neddylation metal ion binding ubiquitin protein ligase activity Cul4-RING E3 ubiquitin ligase complex cullin family protein binding uc009rcm.1 uc009rcm.2 uc009rcm.3 
ENSMUST00000057502.14 H2-M10.4 ENSMUST00000057502.14 histocompatibility 2, M region locus 10.4 (from RefSeq NM_177634.2) ENSMUST00000057502.1 ENSMUST00000057502.10 ENSMUST00000057502.11 ENSMUST00000057502.12 ENSMUST00000057502.13 ENSMUST00000057502.2 ENSMUST00000057502.3 ENSMUST00000057502.4 ENSMUST00000057502.5 ENSMUST00000057502.6 ENSMUST00000057502.7 ENSMUST00000057502.8 ENSMUST00000057502.9 H2-M10.4 NM_177634 Q85ZW8 Q85ZW8_MOUSE uc008cla.1 uc008cla.2 uc008cla.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc008cla.1 uc008cla.2 uc008cla.3 
ENSMUST00000057503.7 Lamp5 ENSMUST00000057503.7 lysosomal-associated membrane protein family, member 5, transcript variant 1 (from RefSeq NM_029530.3) ENSMUST00000057503.1 ENSMUST00000057503.2 ENSMUST00000057503.3 ENSMUST00000057503.4 ENSMUST00000057503.5 ENSMUST00000057503.6 LAMP5_MOUSE NM_029530 Q9CXQ4 Q9D387 uc008mog.1 uc008mog.2 Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. Cytoplasmic vesicle membrane ; Single-pass type I membrane protein Cell membrane ; Single-pass type I membrane protein Cell projection, dendrite Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein Cell projection, growth cone membrane ; Single-pass type I membrane protein Early endosome membrane ; Single-pass type I membrane protein Recycling endosome Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein Endosome membrane ; Single-pass type I membrane protein Note=Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:17215451). Colocalizes with UNC93B1 in large endosomal intracellular vesicles (By similarity). Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides (By similarity). Associates with cortical membranes (By similarity). Localizes mostly in cytoplasmic vesicles of neuronal cell body (PubMed:17215451). Localizes to synaptic vesicles in a subset of GABAergic neurons (PubMed:27272053). In brain, strongly expressed in the globus pallidus/ventral pallidum complex, the substantia nigra pars reticulata and the entopeduncular nucleus (at protein level) (PubMed:27272053). Expressed in the external plexiform layer of the olfactory bulb (at protein level). May be weakly expressed in neocortex and striatum (at protein level) (PubMed:27272053). Highly expressed in brain; not detected in other tissues tested (PubMed:17215451). Detected in the cingulate cortex, cortical plate and caudate putamen (PubMed:17215451). In neocortex, specifically expressed in neurons of layers II/III and V (PubMed:17215451). Expressed in embryo at 14 dpc. Glycosylated. Gross morphology and brain structure are normal. Behavioral assays of locomotory activity, exploratory behavior and motor coordination are also normal. However, some subtle behavioral defects are observed: anxiety levels are decreased and animals also show mild defects in odor discrimination. Electrophysiological assays of striatopallidal synapses indicate defects in short-term synaptic plasticity. Belongs to the LAMP family. Sequence=AAH04791.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AK018222; Type=Frameshift; Evidence=; Sequence=BAB29169.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function lysosome lysosomal membrane endosome late endosome plasma membrane endosome membrane membrane integral component of membrane cell junction dendrite cytoplasmic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle early endosome membrane late endosome membrane growth cone membrane dendrite membrane endoplasmic reticulum-Golgi intermediate compartment membrane cell projection synapse recycling endosome recycling endosome membrane establishment of protein localization to organelle uc008mog.1 uc008mog.2 
ENSMUST00000057525.14 Trim3 ENSMUST00000057525.14 tripartite motif-containing 3, transcript variant 2 (from RefSeq NM_018880.3) ENSMUST00000057525.1 ENSMUST00000057525.10 ENSMUST00000057525.11 ENSMUST00000057525.12 ENSMUST00000057525.13 ENSMUST00000057525.2 ENSMUST00000057525.3 ENSMUST00000057525.4 ENSMUST00000057525.5 ENSMUST00000057525.6 ENSMUST00000057525.7 ENSMUST00000057525.8 ENSMUST00000057525.9 Hac1 NM_018880 Q3UMU5 Q9R1R2 Rnf22 TRIM3_MOUSE uc009iyn.1 uc009iyn.2 uc009iyn.3 uc009iyn.4 E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (PubMed:24086586, PubMed:26527743). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation (By similarity). Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (PubMed:26527743). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (PubMed:24086586). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A. Positively regulates TLR3- mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:26527743). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Forms homooligomers. Interacts with TRIM2; this interaction reduces TRIM2 activity (By similarity). Associates with myosin-Vb (MYO5B) and alpha-actinin-4 (ACTN4) (By similarity). Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with ZFYVE28/LST2 (By similarity). Interacts with KIF21B (PubMed:24086586). Cytoplasm Early endosome Golgi apparatus, trans-Golgi network Cell projection, dendrite Note=Mainly located in the Golgi apparatus and transported to the early endosomes upon stimulation with dsRNA. The interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades. Trim3-knockout mice are viable, fertile and showed no obvious morphological abnormalities (PubMed:24086586). However, they display increased levels of gamma-actin at hippocampal synapses, resulting in higher spine densities, increased long-term potentiation, and enhanced short-term contextual fear memory consolidation (PubMed:26527743). In addition, they express lower levels of antiviral genes and show lower levels of inflammatory response following poly(I:C) but not lipopolysaccharide (LPS) stimulation (PubMed:32878999). Belongs to the TRIM/RBCC family. protein polyubiquitination ubiquitin-protein transferase activity protein binding cytoplasm endosome early endosome Golgi apparatus zinc ion binding protein transport protein ubiquitination dendrite cell projection proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity postsynapse glutamatergic synapse uc009iyn.1 uc009iyn.2 uc009iyn.3 uc009iyn.4 
ENSMUST00000057551.14 Slbp ENSMUST00000057551.14 stem-loop binding protein, transcript variant 1 (from RefSeq NM_009193.2) ENSMUST00000057551.1 ENSMUST00000057551.10 ENSMUST00000057551.11 ENSMUST00000057551.12 ENSMUST00000057551.13 ENSMUST00000057551.2 ENSMUST00000057551.3 ENSMUST00000057551.4 ENSMUST00000057551.5 ENSMUST00000057551.6 ENSMUST00000057551.7 ENSMUST00000057551.8 ENSMUST00000057551.9 NM_009193 Q3U4T7 Q3U4T7_MOUSE Slbp uc008xaw.1 uc008xaw.2 uc008xaw.3 Belongs to the SLBP family. RNA binding mRNA binding nucleus nucleolus cytoplasm cytosol identical protein binding mRNA transport uc008xaw.1 uc008xaw.2 uc008xaw.3 
ENSMUST00000057557.14 Mcmbp ENSMUST00000057557.14 minichromosome maintenance complex binding protein (from RefSeq NM_145955.3) D3Z3G1 ENSMUST00000057557.1 ENSMUST00000057557.10 ENSMUST00000057557.11 ENSMUST00000057557.12 ENSMUST00000057557.13 ENSMUST00000057557.2 ENSMUST00000057557.3 ENSMUST00000057557.4 ENSMUST00000057557.5 ENSMUST00000057557.6 ENSMUST00000057557.7 ENSMUST00000057557.8 ENSMUST00000057557.9 MCMBP_MOUSE NM_145955 Q8R3C0 uc009jzh.1 uc009jzh.2 uc009jzh.3 uc009jzh.4 Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity). Interacts with the MCM complex: associates with the MCM3-7 complex which lacks MCM2, while it does not interact with the MCM complex when MCM2 is present (MCM2-7 complex). Interacts with the RPA complex, when composed of all RPA1, RPA2 and RPA3 components, but not with RPA1 or RPA2 alone (By similarity). Nucleus Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex (By similarity). Belongs to the MCMBP family. nuclear chromatin chromatin binding nucleus nucleoplasm cytosol plasma membrane DNA replication DNA-dependent DNA replication cell cycle sister chromatid cohesion MCM complex cell division uc009jzh.1 uc009jzh.2 uc009jzh.3 uc009jzh.4 
ENSMUST00000057561.9 Wwc2 ENSMUST00000057561.9 WW, C2 and coiled-coil domain containing 2 (from RefSeq NM_133791.5) D8Ertd594e ENSMUST00000057561.1 ENSMUST00000057561.2 ENSMUST00000057561.3 ENSMUST00000057561.4 ENSMUST00000057561.5 ENSMUST00000057561.6 ENSMUST00000057561.7 ENSMUST00000057561.8 MNCb-4173 NM_133791 Q3UGG4 Q3UH10 Q6NXJ0 Q7TMY1 Q8CE61 Q9JJ63 WWC2_MOUSE uc009lrm.1 uc009lrm.2 uc009lrm.3 uc009lrm.4 uc009lrm.5 Negative regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. Forms homodimers and heterodimers with WWC1 and WWC3. Interacts with DLC1 and PRKCZ. Interacts (via WW domains) with LATS1 and LATS2. Cytoplasm, cytosol Belongs to the WWC family. Sequence=BAA97983.1; Type=Frameshift; Evidence=; Sequence=BAE28244.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter cytosol kinase binding negative regulation of hippo signaling negative regulation of organ growth binding, bridging uc009lrm.1 uc009lrm.2 uc009lrm.3 uc009lrm.4 uc009lrm.5 
ENSMUST00000057567.3 Il36g ENSMUST00000057567.3 interleukin 36G (from RefSeq NM_153511.3) ENSMUST00000057567.1 ENSMUST00000057567.2 Il1f9 Il36g NM_153511 Q3U0P4 Q3U0P4_MOUSE uc008ioo.1 uc008ioo.2 uc008ioo.3 uc008ioo.4 Secreted Belongs to the IL-1 family. cytokine activity extracellular region extracellular space inflammatory response immune response signal transduction uc008ioo.1 uc008ioo.2 uc008ioo.3 uc008ioo.4 
ENSMUST00000057569.4 Ltb4r1 ENSMUST00000057569.4 leukotriene B4 receptor 1, transcript variant 1 (from RefSeq NM_008519.3) Bltr ENSMUST00000057569.1 ENSMUST00000057569.2 ENSMUST00000057569.3 LT4R1_MOUSE Ltb4r NM_008519 O88855 uc007uar.1 uc007uar.2 uc007uar.3 uc007uar.4 Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. Cell membrane; Multi-pass membrane protein. Highly expressed on activated leukocytes, including eosinophils. Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization. Belongs to the G-protein coupled receptor 1 family. leukotriene B4 receptor activity G-protein coupled receptor activity galanin receptor activity leukotriene receptor activity plasma membrane integral component of plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane membrane raft leukotriene signaling pathway uc007uar.1 uc007uar.2 uc007uar.3 uc007uar.4 
ENSMUST00000057576.8 Cog7 ENSMUST00000057576.8 component of oligomeric golgi complex 7 (from RefSeq NM_001033318.3) A0A0R4J0Q9 A0A0R4J0Q9_MOUSE Cog7 ENSMUST00000057576.1 ENSMUST00000057576.2 ENSMUST00000057576.3 ENSMUST00000057576.4 ENSMUST00000057576.5 ENSMUST00000057576.6 ENSMUST00000057576.7 NM_001033318 uc009jnz.1 uc009jnz.2 uc009jnz.3 Golgi apparatus membrane ; Peripheral membrane protein Membrane ; Peripheral membrane protein Belongs to the COG7 family. nucleolus Golgi apparatus protein glycosylation intracellular protein transport retrograde vesicle-mediated transport, Golgi to ER Golgi transport complex protein localization to organelle protein localization to Golgi apparatus protein stabilization uc009jnz.1 uc009jnz.2 uc009jnz.3 
ENSMUST00000057578.16 Trnt1 ENSMUST00000057578.16 tRNA nucleotidyl transferase, CCA-adding, 1, transcript variant 1 (from RefSeq NM_001242358.1) ENSMUST00000057578.1 ENSMUST00000057578.10 ENSMUST00000057578.11 ENSMUST00000057578.12 ENSMUST00000057578.13 ENSMUST00000057578.14 ENSMUST00000057578.15 ENSMUST00000057578.2 ENSMUST00000057578.3 ENSMUST00000057578.4 ENSMUST00000057578.5 ENSMUST00000057578.6 ENSMUST00000057578.7 ENSMUST00000057578.8 ENSMUST00000057578.9 NM_001242358 Q3TKW1 Q3UX99 Q8K1J6 Q920N6 Q9CSX0 TRNT1_MOUSE uc009dcz.1 uc009dcz.2 uc009dcz.3 uc009dcz.4 Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Promotes tRNA repair and recycling downstream of the ribosome-associated quality control (RQC) pathway by mediating addition of the tRNA 3'-terminal CCA following cleavage by ANKZF1 and repair by ELAC1. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs and tRNA-like transcripts. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs beginning with GG are marked with CCACCA and rapidly degraded. The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA. This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle. Reaction=a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate; Xref=Rhea:RHEA:14433, Rhea:RHEA-COMP:10465, Rhea:RHEA- COMP:10468, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:74896, ChEBI:CHEBI:83071; EC=2.7.7.72; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14434; Evidence=; Reaction=a tRNA with a 3' CCA end + ATP + 2 CTP = a tRNA with a 3' CCACCA end + 3 diphosphate; Xref=Rhea:RHEA:76235, Rhea:RHEA- COMP:10468, Rhea:RHEA-COMP:18655, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:83071, ChEBI:CHEBI:195187; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76236; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Monomer, and homodimer. Mitochondrion Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K1J6-1; Sequence=Displayed; Name=2; IsoId=Q8K1J6-2; Sequence=VSP_018616, VSP_018617; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. tRNA binding nucleotide binding tRNA 3'-terminal CCA addition RNA binding ATP binding mitochondrion RNA processing tRNA processing tRNA nucleotidyltransferase activity transferase activity nucleotidyltransferase activity CTP:tRNA cytidylyltransferase activity CTP:3'-cytidine-tRNA cytidylyltransferase activity ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity mitochondrial tRNA 3'-end processing uc009dcz.1 uc009dcz.2 uc009dcz.3 uc009dcz.4 
ENSMUST00000057596.10 Or7d10 ENSMUST00000057596.10 olfactory receptor family 7 subfamily D member 10 (from RefSeq NM_146339.3) ENSMUST00000057596.1 ENSMUST00000057596.2 ENSMUST00000057596.3 ENSMUST00000057596.4 ENSMUST00000057596.5 ENSMUST00000057596.6 ENSMUST00000057596.7 ENSMUST00000057596.8 ENSMUST00000057596.9 NM_146339 Olfr77 Or7d10 Q8VEY9 Q8VEY9_MOUSE uc009ohy.1 uc009ohy.2 uc009ohy.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC046590.1, BQ714445.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ohy.1 uc009ohy.2 uc009ohy.3 
ENSMUST00000057598.7 Mblac2 ENSMUST00000057598.7 metallo-beta-lactamase domain containing 2 (from RefSeq NM_028372.1) ENSMUST00000057598.1 ENSMUST00000057598.2 ENSMUST00000057598.3 ENSMUST00000057598.4 ENSMUST00000057598.5 ENSMUST00000057598.6 G3X997 MBLC2_MOUSE NM_028372 Q8BL86 uc007ria.1 uc007ria.2 uc007ria.3 Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18. Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence=; Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence=; Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=; Reaction=H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate; Xref=Rhea:RHEA:30139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30140; Evidence=; Reaction=a beta-lactam + H2O = a substituted beta-amino acid; Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627, ChEBI:CHEBI:140347; EC=3.5.2.6; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Endoplasmic reticulum membrane ; Lipid-anchor Cell membrane ; Lipid-anchor Palmitoylated on Cys-254 by ZDHHC20. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. biological_process hydrolase activity metal ion binding uc007ria.1 uc007ria.2 uc007ria.3 
ENSMUST00000057608.5 Lrrc3 ENSMUST00000057608.5 leucine rich repeat containing 3 (from RefSeq NM_145152.4) ENSMUST00000057608.1 ENSMUST00000057608.2 ENSMUST00000057608.3 ENSMUST00000057608.4 Lrrc3 NM_145152 Q543Z4 Q543Z4_MOUSE uc007fwi.1 uc007fwi.2 uc007fwi.3 uc007fwi.4 uc007fwi.5 membrane integral component of membrane uc007fwi.1 uc007fwi.2 uc007fwi.3 uc007fwi.4 uc007fwi.5 
ENSMUST00000057610.8 Daam2 ENSMUST00000057610.8 dishevelled associated activator of morphogenesis 2, transcript variant 3 (from RefSeq NM_001379372.1) DAAM2_MOUSE Daam2 E9QNU9 ENSMUST00000057610.1 ENSMUST00000057610.2 ENSMUST00000057610.3 ENSMUST00000057610.4 ENSMUST00000057610.5 ENSMUST00000057610.6 ENSMUST00000057610.7 Kiaa0381 NM_001379372 Q6TAB7 Q80U19 Q810J5 uc008cyl.1 uc008cyl.2 uc008cyl.3 Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system (PubMed:22227309, PubMed:24091014, PubMed:25754822). Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1) (PubMed:22227309, PubMed:25754822). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity (PubMed:22227309). During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A (PubMed:25754822). Also regulates non-canonical Wnt signaling pathway (PubMed:24091014). Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation (PubMed:24091014). Together with DAAM1, required for myocardial maturation and sarcomere assembly (PubMed:26526197). Is a regulator of actin nucleation and elongation, filopodia formation and podocyte migration (By similarity). Interacts with DVL3. Interacts with INF2 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80U19-1; Sequence=Displayed; Name=2; IsoId=Q80U19-2; Sequence=VSP_008005, VSP_008006; In early embryogenesis, expression is confined to embryonic ectoderm. Highly dynamic expression in later stages of gastrulation. In early somite stages, detected in posterior node and persists until 9-10 somites have developed when expression is concentrated in the chordoneural hinge. During organogenesis, expressed in the CNS, PNS, liver primordia, limb buds and genital tubercle. Expressed in the embryonic myocardium: not expressed in the myocardium at 9.5 dpc but is present in epicardial cells. At 10.5 dpc, expressed in the mesenchyme surrounding the ventral foregut and in regions enriched in cardiac progenitors, as well as the epicardium and lining of the pericardial cavity. By 12.5 dpc, expressed throughout the myocardium and ventricular trabeculae. The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity). Conditional knockout mice lacking Daam2 in myocardial cells do not show any heart defects. Conditional knockout mice lacking Daam1 and Daam2 in myocardial cells show cardiomyopathy, which is stronger than with a single Daam1 deletion. Belongs to the formin homology family. Sequence=BAC65548.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC65548.2; Type=Miscellaneous discrepancy; Note=Partially unspliced pre-RNA.; Evidence=; actin binding protein binding determination of left/right symmetry cellular component organization Wnt signaling pathway Rho GTPase binding dorsal spinal cord development actin cytoskeleton organization negative regulation of oligodendrocyte differentiation regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of non-canonical Wnt signaling pathway uc008cyl.1 uc008cyl.2 uc008cyl.3 
ENSMUST00000057612.9 Ssc5d ENSMUST00000057612.9 scavenger receptor cysteine rich family, 5 domains (from RefSeq NM_173008.3) B2RUB0 C6ZFQ2 ENSMUST00000057612.1 ENSMUST00000057612.2 ENSMUST00000057612.3 ENSMUST00000057612.4 ENSMUST00000057612.5 ENSMUST00000057612.6 ENSMUST00000057612.7 ENSMUST00000057612.8 NM_173008 Q3TMW2 Q8BV57 S5D-SRCRB SRCRL_MOUSE uc009eza.1 uc009eza.2 uc009eza.3 Binds to extracellular matrix proteins. Binds to pathogen- associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces. Interacts with LGALS1 and laminin. Secreted Cytoplasm Detected throughout the gastrointestinal and genitourinary tracts, in serosal salivary gland, the exocrine part of pancreas and testis, as well as in a few tubular structures in kidney. Not detected in lung and heart (at protein level). Strongly expressed in testis, kidney and pancreas, with lower levels detected in bone marrow, spleen, lung, liver, colon, stomach and skeletal muscle. Very low levels or no expression detected in thymus, esophagus, jejunum, ileum, duodenum, ovary, uterus, heart, trachea, brain, cerebellum and bladder. At 9.5 dpc, detected in placodes, ectodermal thickenings where organs or structures will develop. Expression levels increase substantially between 9 and 14 dpc. Partially N- and O-glycosylated. fibronectin binding immune system process scavenger receptor activity protein binding extracellular region extracellular space cytoplasm endocytosis defense response multicellular organism development membrane detection of bacterial lipoprotein laminin binding innate immune response defense response to Gram-negative bacterium defense response to Gram-positive bacterium extracellular matrix binding regulation of interleukin-8 secretion negative regulation of interleukin-8 secretion uc009eza.1 uc009eza.2 uc009eza.3 
ENSMUST00000057613.3 Gdf6 ENSMUST00000057613.3 growth differentiation factor 6 (from RefSeq NM_013526.1) Bmp13 ENSMUST00000057613.1 ENSMUST00000057613.2 GDF6_MOUSE Gdf-6 Gdf16 NM_013526 P43028 Q70UT4 uc008ryt.1 uc008ryt.2 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mice lacking a functional copy of this gene exhibit joint and skeletal defects. [provided by RefSeq, Sep 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ537425.1, BC141339.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal- ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures (PubMed:26774823). Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:12606286, PubMed:16049014). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (PubMed:23527555). Homodimer; disulfide-linked. Secreted Expressed in different subsets of developing joints. Highly expressed in the cochlea (PubMed:32369452). Strongly up-regulated in tibialis anterior muscles after denervation. Mice lacking GDF6 display photoreceptor degeneration. Animals exhibit abnormal electroretinograms with up to 66% decreases in the bipolar cell-driven b-wave and 54% decreases in the photoreceptor-mediated a-wave amplitudes, as well as 3 to 27% reduced photopic flicker fusion. The lengths, but not the widths, of dermal flat bones in the skull and the digits are significantly shorter than in wild type (PubMed:26774823). GDF6-knockout mice also shows cochlear aplasia, while the vestibular anatomy is normal (PubMed:32369452). Belongs to the TGF-beta family. cytokine activity transforming growth factor beta receptor binding extracellular region extracellular space apoptotic process multicellular organism development growth factor activity positive regulation of pathway-restricted SMAD protein phosphorylation BMP signaling pathway positive regulation of chondrocyte differentiation activin receptor signaling pathway protein homodimerization activity regulation of apoptotic process regulation of MAPK cascade fat cell differentiation positive regulation of neuron differentiation positive regulation of transcription, DNA-templated cell development pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction positive regulation of p38MAPK cascade retinal cell apoptotic process uc008ryt.1 uc008ryt.2 
ENSMUST00000057623.14 Lmnb2 ENSMUST00000057623.14 lamin B2, transcript variant 1 (from RefSeq NM_010722.5) A0A0R4J0Q5 A0A0R4J0Q5_MOUSE ENSMUST00000057623.1 ENSMUST00000057623.10 ENSMUST00000057623.11 ENSMUST00000057623.12 ENSMUST00000057623.13 ENSMUST00000057623.2 ENSMUST00000057623.3 ENSMUST00000057623.4 ENSMUST00000057623.5 ENSMUST00000057623.6 ENSMUST00000057623.7 ENSMUST00000057623.8 ENSMUST00000057623.9 Lmnb2 NM_010722 uc007gfk.1 uc007gfk.2 uc007gfk.3 This gene encodes a protein component of the nuclear lamina, which provides a structural framework for the nuclear envelope. Defects in this gene were found to cause abnormalities in the shape of neurons. This locus represents one of two B-type lamin genes that may be partially, but not entirely, functionally redundant in neuronal development. Loss of both B-type lamin genes in keratinocytes results in ichthyosis and a skin barrier defect leading to dehydration. Alternative transcriptional initiation and splicing results in multiple transcript variants and protein isoforms, including an isoform with a shorter N-terminal rod domain that may function in nuclear envelope remodeling during spermatogenesis. A related pseudogene is found on chromosome 5. [provided by RefSeq, Sep 2017]. Nucleus lamina Belongs to the intermediate filament family. intermediate filament uc007gfk.1 uc007gfk.2 uc007gfk.3 
ENSMUST00000057625.3 Arxes1 ENSMUST00000057625.3 adipocyte-related X-chromosome expressed sequence 1 (from RefSeq NM_029541.3) ARXS2_MOUSE Arxes2 B1AUR7 C0HK80 ENSMUST00000057625.1 ENSMUST00000057625.2 NM_029541 Q8BK31 Q9D365 Q9D6F2 uc012hot.1 uc012hot.2 Plays a role in adipogenesis. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Strongly expressed in epididymal white and brown adipose tissue with low levels in heart. Strongly up-regulated during adipogenesis. By the PPARG agonist rosiglitazone. Arxes1 and Arxes2 appear to have arisen by retrotransposition of the signal peptidase Spcs3 followed by a segmental duplication event. Belongs to the SPCS3 family. endoplasmic reticulum signal peptidase complex endoplasmic reticulum membrane signal peptide processing peptidase activity membrane integral component of membrane protein targeting to ER fat cell differentiation uc012hot.1 uc012hot.2 
ENSMUST00000057627.16 Spata2 ENSMUST00000057627.16 spermatogenesis associated 2, transcript variant 1 (from RefSeq NM_170756.3) ENSMUST00000057627.1 ENSMUST00000057627.10 ENSMUST00000057627.11 ENSMUST00000057627.12 ENSMUST00000057627.13 ENSMUST00000057627.14 ENSMUST00000057627.15 ENSMUST00000057627.2 ENSMUST00000057627.3 ENSMUST00000057627.4 ENSMUST00000057627.5 ENSMUST00000057627.6 ENSMUST00000057627.7 ENSMUST00000057627.8 ENSMUST00000057627.9 NM_170756 Q3TAH0 Q3UML2 Q8K004 SPAT2_MOUSE Spata2 uc008nzs.1 uc008nzs.2 uc008nzs.3 Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (By similarity). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (By similarity). Required to activate the 'Met- 1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:28701375). Controls the kinase activity of RIPK1 and TNF-alpha- induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (PubMed:28701375). Interacts (via the PIM motif) with RNF31/HOIP (via the PUB domain); the interaction is direct. Interacts (via the PUB domain) with CYLD; the interaction is direct. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K004-1; Sequence=Displayed; Name=2; IsoId=Q8K004-2; Sequence=VSP_059905, VSP_059906; Widely expressed, with highest expression in testis, lung and intestine, and lower expression in brain, heart and spleen (PubMed:28701375). Present at high level in Sertoli cells: expressed from stage I to stage XII of the testis seminiferous epithelium (at protein level) (PubMed:29025062). Mice are fertile and healthy with no obvious abnormalities in major organs in normal conditions (PubMed:29025062, PubMed:28701375). Males however display a decreased fertility: they show reduced testis size and sperm number (PubMed:29025062). The proliferation of germ cells in the seminiferous tubules is decreased in male gonads (PubMed:29025062). Impaired necroptosis: deficient cells show resistance to RIPK1-dependent apoptosis and necroptosis and are partially protected against RIPK1-independent apoptosis (PubMed:28701375). Belongs to the SPATA2 family. fibrillar center molecular_function nucleus cytoplasm regulation of tumor necrosis factor-mediated signaling pathway programmed cell death regulation of inflammatory response regulation of necroptotic process protein K63-linked deubiquitination protein linear deubiquitination uc008nzs.1 uc008nzs.2 uc008nzs.3 
ENSMUST00000057633.4 Tas2r119 ENSMUST00000057633.4 taste receptor, type 2, member 119 (from RefSeq NM_020503.3) ENSMUST00000057633.1 ENSMUST00000057633.2 ENSMUST00000057633.3 G3X986 G3X986_MOUSE NM_020503 Tas2r119 uc007vkm.1 uc007vkm.2 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor T2R family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane response to stimulus sensory perception of taste uc007vkm.1 uc007vkm.2 
ENSMUST00000057645.6 Gpr101 ENSMUST00000057645.6 G protein-coupled receptor 101 (from RefSeq NM_001033360.3) ENSMUST00000057645.1 ENSMUST00000057645.2 ENSMUST00000057645.3 ENSMUST00000057645.4 ENSMUST00000057645.5 GP101_MOUSE Gm365 NM_001033360 Q3UUI9 Q80T62 uc009thn.1 uc009thn.2 uc009thn.3 Orphan receptor. Cell membrane; Multi-pass membrane protein. Expressed in the brain in hypothalamus. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity adrenergic receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway membrane integral component of membrane receptor complex adenylate cyclase-activating adrenergic receptor signaling pathway uc009thn.1 uc009thn.2 uc009thn.3 
ENSMUST00000057649.8 Pam16l ENSMUST00000057649.8 Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. (from UniProt Q9CQV1) AK008380 ENSMUST00000057649.1 ENSMUST00000057649.2 ENSMUST00000057649.3 ENSMUST00000057649.4 ENSMUST00000057649.5 ENSMUST00000057649.6 ENSMUST00000057649.7 Magmas Pam16 Q6EIX1 Q9CQV1 TIM16_MOUSE Tim16 Timm16 uc287qwi.1 uc287qwi.2 Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Interacts with DNAJC19. Directly interacts with DNAJC15; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity (By similarity). Associates with the TIM23 complex (Probable). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Expressed in trabecular bone and cartilage and by differentiated chondrocytes localized in the hypertrophic zone and by osteoblasts at early developmental stages. The J-like region, although related to the J domain does not have co-chaperone activity. Belongs to the TIM16/PAM16 family. presequence translocase-associated import motor ossification molecular_function cytoplasm mitochondrion mitochondrial inner membrane mitochondrial inner membrane presequence translocase complex mitochondrial matrix protein transport membrane protein import into mitochondrial matrix extrinsic component of mitochondrial inner membrane negative regulation of ATPase activity macromolecular complex negative regulation of apoptotic process DNA biosynthetic process negative regulation of release of cytochrome c from mitochondria negative regulation of apoptotic DNA fragmentation negative regulation of apoptotic signaling pathway uc287qwi.1 uc287qwi.2 
ENSMUST00000057652.7 Zfp420 ENSMUST00000057652.7 zinc finger protein 420, transcript variant 3 (from RefSeq NM_001364619.1) ENSMUST00000057652.1 ENSMUST00000057652.2 ENSMUST00000057652.3 ENSMUST00000057652.4 ENSMUST00000057652.5 ENSMUST00000057652.6 NM_001364619 Q7TMN8 Q7TMN8_MOUSE Zfp420 uc009gck.1 uc009gck.2 uc009gck.3 uc009gck.4 transcription regulatory region sequence-specific DNA binding blastocyst hatching molecular_function nucleic acid binding cellular_component nucleus metal ion binding uc009gck.1 uc009gck.2 uc009gck.3 uc009gck.4 
ENSMUST00000057653.8 Car5a ENSMUST00000057653.8 carbonic anhydrase 5a, mitochondrial (from RefSeq NM_007608.2) CAH5A_MOUSE Ca5 Ca5a Car5 ENSMUST00000057653.1 ENSMUST00000057653.2 ENSMUST00000057653.3 ENSMUST00000057653.4 ENSMUST00000057653.5 ENSMUST00000057653.6 ENSMUST00000057653.7 NM_007608 P23589 uc009nsf.1 uc009nsf.2 uc009nsf.3 uc009nsf.4 uc009nsf.5 Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3 (PubMed:7937950). Mitochondria are impermeable to HCO3, and thus this intramitochondrial carbonic anhydrase is pivotal in providing HCO3 for multiple mitochondrial enzymes that catalyze the formation of essential metabolites of intermediary metabolism in the urea and Krebs cycles (By similarity). Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10749; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:10750; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= pH dependence: Optimum pH is 7-8. ; Mitochondrion Liver. Belongs to the alpha-carbonic anhydrase family. carbonate dehydratase activity mitochondrion gluconeogenesis zinc ion binding lyase activity metal ion binding uc009nsf.1 uc009nsf.2 uc009nsf.3 uc009nsf.4 uc009nsf.5 
ENSMUST00000057669.16 Mapk3 ENSMUST00000057669.16 mitogen-activated protein kinase 3 (from RefSeq NM_011952.2) ENSMUST00000057669.1 ENSMUST00000057669.10 ENSMUST00000057669.11 ENSMUST00000057669.12 ENSMUST00000057669.13 ENSMUST00000057669.14 ENSMUST00000057669.15 ENSMUST00000057669.2 ENSMUST00000057669.3 ENSMUST00000057669.4 ENSMUST00000057669.5 ENSMUST00000057669.6 ENSMUST00000057669.7 ENSMUST00000057669.8 ENSMUST00000057669.9 Erk1 MK03_MOUSE NM_011952 Prkm3 Q61531 Q63844 Q8K0X5 Q91YW5 uc009jsm.1 uc009jsm.2 uc009jsm.3 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DEPTOR, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-203 and Tyr-205 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Dephosphorylated and inactivated by DUSP3, DUSP6 and DUSP9. Binds both upstream activators and downstream substrates in multimolecular complexes. Found in a complex with at least BRAF, HRAS, MAP2K1/MEK1, MAPK3 and RGS14. Interacts with TPR. Interacts with ADAM15, ARRB2, CANX, DAPK1 (via death domain), HSF4, IER3, MAP2K1/MEK1, NISCH, and SGK1 (By similarity). Interacts with MORG1 (PubMed:15118098). Interacts with PEA15 (PubMed:11702783). Interacts with isoform 1 of MKNK2 and this binding prevents from dephosphorylation and inactivation (PubMed:16162500). Interacts with CDKN2AIP. Interacts with HSF1 (via D domain and preferentially with hyperphosphorylated form); this interaction occurs upon heat shock. Interacts with CAVIN4 (By similarity). Interacts with GIT1; this interaction is necessary for MAPK3 localization to focal adhesions (PubMed:15923189). Interacts with ZNF263 (By similarity). Interacts with EBF4. Q63844; Q60793: Klf4; NbExp=3; IntAct=EBI-397682, EBI-3043905; Cytoplasm Nucleus. Membrane, caveola Cell junction, focal adhesion Note=Autophosphorylation at Thr-207 promotes nuclear localization (By similarity). PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (PubMed:11702783). The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. Dually phosphorylated on Thr-203 and Tyr-205, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation (By similarity). Dephosphorylated by PTPRJ at Tyr-205 (By similarity). Autophosphorylated on threonine and tyrosine residues in vitro. Phosphorylated upon FLT3 and KIT signaling (By similarity). Ubiquitinated by TRIM15 via 'Lys-63'-linked ubiquitination; leading to activation. Deubiquitinated by CYLD. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. MAPK cascade nucleotide binding activation of MAPK activity phosphotyrosine binding positive regulation of protein phosphorylation positive regulation of cytokine secretion involved in immune response protein kinase activity protein serine/threonine kinase activity MAP kinase activity MAP kinase kinase activity protein binding ATP binding nucleus nuclear envelope nucleoplasm cytoplasm mitochondrion early endosome late endosome Golgi apparatus cytosol cytoskeleton plasma membrane caveola focal adhesion transcription, DNA-templated protein phosphorylation apoptotic process cellular response to DNA damage stimulus DNA damage induced protein phosphorylation cell cycle signal transduction aging response to toxic substance animal organ morphogenesis regulation of gene expression positive regulation of gene expression positive regulation of macrophage chemotaxis neural crest cell development membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation sensory perception of pain arachidonic acid metabolic process phosphatase binding regulation of ossification BMP signaling pathway regulation of cellular pH thyroid gland development pseudopodium positive regulation of cyclase activity lipopolysaccharide-mediated signaling pathway positive regulation of telomere maintenance via telomerase response to lipopolysaccharide regulation of stress-activated MAPK cascade macromolecular complex positive regulation of histone phosphorylation cellular response to amino acid starvation cellular response to reactive oxygen species positive regulation of histone acetylation intracellular signal transduction peptidyl-tyrosine autophosphorylation outer ear morphogenesis identical protein binding response to exogenous dsRNA positive regulation of translation positive regulation of transcription from RNA polymerase II promoter decidualization thymus development regulation of sequence-specific DNA binding transcription factor activity cartilage development stress-activated MAPK cascade regulation of cytoskeleton organization positive regulation of telomerase activity Bergmann glial cell differentiation face development lung morphogenesis trachea formation cardiac neural crest cell development involved in heart development macromolecular complex assembly ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade interleukin-1-mediated signaling pathway response to epidermal growth factor cellular response to mechanical stimulus cellular response to cadmium ion cellular response to organic substance cellular response to tumor necrosis factor caveolin-mediated endocytosis regulation of Golgi inheritance scaffold protein binding cellular response to dopamine positive regulation of telomere capping positive regulation of xenophagy positive regulation of metallopeptidase activity regulation of early endosome to late endosome transport negative regulation of apolipoprotein binding uc009jsm.1 uc009jsm.2 uc009jsm.3 
ENSMUST00000057676.7 Ubald2 ENSMUST00000057676.7 UBA-like domain containing 2 (from RefSeq NM_176902.3) A2AAP1 ENSMUST00000057676.1 ENSMUST00000057676.2 ENSMUST00000057676.3 ENSMUST00000057676.4 ENSMUST00000057676.5 ENSMUST00000057676.6 Fam100b NM_176902 Q3UMH5 Q8BQH4 UBAD2_MOUSE uc007mlb.1 uc007mlb.2 Belongs to the UBALD family. Sequence=BAE26123.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component biological_process uc007mlb.1 uc007mlb.2 
ENSMUST00000057685.3 Gltpd2 ENSMUST00000057685.3 glycolipid transfer protein domain containing 2 (from RefSeq NM_146020.1) ENSMUST00000057685.1 ENSMUST00000057685.2 GLTD2_MOUSE NM_146020 Q8K0R6 uc007jvd.1 uc007jvd.2 uc007jvd.3 Belongs to the GLTP family. cytoplasm cytosol lipid binding ceramide transport ceramide 1-phosphate binding ceramide 1-phosphate transporter activity ceramide 1-phosphate transport uc007jvd.1 uc007jvd.2 uc007jvd.3 
ENSMUST00000057686.5 Tas2r139 ENSMUST00000057686.5 taste receptor, type 2, member 139 (from RefSeq NM_181275.1) ENSMUST00000057686.1 ENSMUST00000057686.2 ENSMUST00000057686.3 ENSMUST00000057686.4 NM_181275 Q7TQA5 T2R39_MOUSE T2r34 Tas2r39 uc009bqm.1 uc009bqm.2 Putative taste receptor which may play a role in the perception of bitterness. Membrane; Multi-pass membrane protein. Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway taste receptor activity membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009bqm.1 uc009bqm.2 
ENSMUST00000057692.11 Luc7l2 ENSMUST00000057692.11 LUC7-like 2 (S. cerevisiae), transcript variant 1 (from RefSeq NM_138680.3) ENSMUST00000057692.1 ENSMUST00000057692.10 ENSMUST00000057692.2 ENSMUST00000057692.3 ENSMUST00000057692.4 ENSMUST00000057692.5 ENSMUST00000057692.6 ENSMUST00000057692.7 ENSMUST00000057692.8 ENSMUST00000057692.9 LC7L2_MOUSE NM_138680 Q7TNC4 Q99LM5 Q99PC3 uc009bkm.1 uc009bkm.2 uc009bkm.3 uc009bkm.4 uc009bkm.5 May bind to RNA via its Arg/Ser-rich domain. Interacts with SCNM1. Nucleus speckle Nucleus, nucleoplasm Note=Colocalizes with SCNM1 and SNRNP70 in nuclear speckles. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q7TNC4-1; Sequence=Displayed; Name=2; IsoId=Q7TNC4-2; Sequence=VSP_010218, VSP_010219, VSP_010220; Name=3; IsoId=Q7TNC4-3; Sequence=VSP_010219, VSP_010220; Name=4; IsoId=Q7TNC4-4; Sequence=VSP_010218; All isoforms are expressed in brain, kidney, heart, thymus, stomach, skeletal muscle, testis and spinal cord. Belongs to the Luc7 family. mRNA binding nucleus nucleoplasm U1 snRNP mRNA splice site selection nuclear speck enzyme binding U2-type prespliceosome uc009bkm.1 uc009bkm.2 uc009bkm.3 uc009bkm.4 uc009bkm.5 
ENSMUST00000057716.6 Catsperz ENSMUST00000057716.6 cation channel sperm associated auxiliary subunit zeta (from RefSeq NM_001039494.2) CTSRZ_MOUSE Catsperz ENSMUST00000057716.1 ENSMUST00000057716.2 ENSMUST00000057716.3 ENSMUST00000057716.4 ENSMUST00000057716.5 NM_001039494 Q9CQP8 Q9DAA2 Q9DAP8 Tex40 uc008gji.1 uc008gji.2 uc008gji.3 Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation (PubMed:28226241, PubMed:31056283, PubMed:34225353). Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (PubMed:28226241, PubMed:31056283). Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract (PubMed:28226241). Together with EFCAB9, associates with the CatSper channel pore and is required for the two- row structure of each single CatSper channel (PubMed:31056283). Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG2, CATSPERD, CATSPERE, CATSPERZ, C2CD6/CATSPERT, SLCO6C1, TMEM249, TMEM262 and EFCAB9 (PubMed:34225353, PubMed:28226241). HSPA1 may be an additional auxiliary complex member (By similarity). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (PubMed:34225353). The auxiliary CATSPERB, CATSPERG2, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively (PubMed:34225353). SLCO6C1 interacts with CATSPERE and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex (PubMed:34225353). C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane (Probable). Interacts with EFCAB9; the interaction is direct, Ca(2+)-dependent and connects EFCAB9 with the CatSper complex (PubMed:31056283). Dissociates from EFCAB9 at elevated pH (PubMed:31056283). Cell projection, cilium, flagellum membrane ; Peripheral membrane protein Note=Specifically located in the principal piece of sperm tail (PubMed:28226241). Although it does not contain a transmembrane domain, localizes with the CatSper complex at the flagellum membrane (PubMed:28226241). Testis-specific (PubMed:20339383, PubMed:28226241). Expressed in adult but not in fetal testis (PubMed:20339383). Not expressed in ovary. Within testis, expression is restricted to spermatids (PubMed:20339383). Mice are normal but males show severe male subfertility. Mutant males display fragmented patterns of CatSper complex stripes in the tails of their sperm, leading to a reduction of calcium ions that pass through the channels to enter the cell. As consequence, the sperm tail is more rigid, preventing it from moving efficiently within the female. Mutant sperm are less able to penetrate the egg than normal sperm. molecular_function protein binding cytoplasm plasma membrane cilium male meiosis spermatogenesis membrane cell differentiation flagellated sperm motility motile cilium CatSper complex cell projection sperm capacitation sperm principal piece uc008gji.1 uc008gji.2 uc008gji.3 
ENSMUST00000057717.8 Zfp319 ENSMUST00000057717.8 zinc finger protein 319 (from RefSeq NM_024467.4) ENSMUST00000057717.1 ENSMUST00000057717.2 ENSMUST00000057717.3 ENSMUST00000057717.4 ENSMUST00000057717.5 ENSMUST00000057717.6 ENSMUST00000057717.7 NM_024467 Q9ERR8 ZN319_MOUSE Znf319 uc009myf.1 uc009myf.2 uc009myf.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus biological_process metal ion binding uc009myf.1 uc009myf.2 uc009myf.3 
ENSMUST00000057722.3 Gm9837 ENSMUST00000057722.3 Gm9837 (from geneSymbol) AK076795 ENSMUST00000057722.1 ENSMUST00000057722.2 uc287yci.1 uc287yci.2 uc287yci.1 uc287yci.2 
ENSMUST00000057725.10 Samhd1 ENSMUST00000057725.10 SAM domain and HD domain, 1, transcript variant 1 (from RefSeq NM_018851.4) E9Q0K6 ENSMUST00000057725.1 ENSMUST00000057725.2 ENSMUST00000057725.3 ENSMUST00000057725.4 ENSMUST00000057725.5 ENSMUST00000057725.6 ENSMUST00000057725.7 ENSMUST00000057725.8 ENSMUST00000057725.9 F8WJE0 Mg21 NM_018851 Q3U5X2 Q543A4 Q60710 Q91VK8 SAMH1_MOUSE Samhd1 uc012chy.1 uc012chy.2 uc012chy.3 [Isoform 1]: Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (By similarity). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:23972988, PubMed:23872947, PubMed:26667483, PubMed:31548683, PubMed:29379009). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:26667483). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (By similarity). Phosphorylation at Thr- 634 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (By similarity). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (By similarity). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (By similarity). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (By similarity). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (PubMed:29669924). Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'- deoxyribonucleoside + H(+) + triphosphate; Xref=Rhea:RHEA:46148, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036, ChEBI:CHEBI:18274, ChEBI:CHEBI:61560; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Allosterically activated and regulated via the combined actions of GTP and dNTPs (dATP, dGTP, dTTP and dCTP): Allosteric site 1 binds GTP, while allosteric site 2 binds dNTP. Allosteric activation promotes the formation of highly active homotetramers. Isoform 1: Phosphorylation at Thr-634 impairs homotetramerization, thereby inhibiting dNTPase activity, leading to reduced ability to restrict infection by viruses. Homodimer; in absence of GTP and dNTP (By similarity). Homotetramer; in GTP- and dNTP-bound form (PubMed:29379009). Interacts with MRE11; leading to stimulate the exonuclease activity of MRE11 (By similarity). Interacts with RBBP8/CtIP (By similarity). Interacts with RBBP8/CtIP. Interacts (via its C-terminus) with CD81. Nucleus Chromosome Note=Localizes to sites of DNA double-strand breaks in response to DNA damage. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60710-1; Sequence=Displayed; Name=2; IsoId=Q60710-2; Sequence=VSP_059661; By interferon alpha, beta and gamma (IFN-alpha, IFN-beta and IFN-gamma). In mouse, the SAM domain is required for deoxynucleoside triphosphate (dNTPase) activity and ability to restrict infection by viruses. It acts by capping allosteric sites. [Isoform 1]: Phosphorylation at Thr-634 by CDK1 acts as a switch to control deoxynucleoside triphosphate (dNTPase)-dependent and -independent functions (PubMed:26667483) (By similarity). Phosphorylation at Thr-634 takes place in cycling cells: it reduces the stability of the homotetramer, impairing the dNTPase activity and subsequent ability to restrict infection by viruses (Probable). It also inhibits ability to suppress LINE-1 retrotransposon activity (PubMed:26667483). In contrast, phosphorylation at Thr-634 promotes DNA end resection at stalled replication forks in response to DNA damage (By similarity). [Isoform 1]: (Microbial infection) Phosphorylation at Thr-634 by mouse cytomegalovirus kinase M97 leads to a reduced level of dNTP hydrolase activity and the loss of viral restriction. [Isoform 2]: Not phosphorylated by CDK1 at the C-terminus. Mice are viable and fertile but show increased cellular dNTP concentrations and impaired ability to restrict retroviral replication in lymphocytes, macrophages and dendritic cells (PubMed:23972988). Mice also display interferon (IFN)-beta-dependent transcriptional up-regulation of type I IFN-inducible genes in various cell types indicative of spontaneous IFN production (PubMed:23972988, PubMed:23872947). In addition, the replication of mouse cytomegalovirus is significantly enhanced in mutant mice (PubMed:31548683). Belongs to the SAMHD1 family. Sequence=AAA66219.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAA66219.1; Type=Frameshift; Evidence=; Sequence=AAH12721.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH67198.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC35801.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE30313.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE31954.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding double-strand break repair via homologous recombination immune system process nucleic acid binding single-stranded DNA binding RNA binding catalytic activity ribonuclease activity GTP binding nucleus nucleoplasm chromosome plasma membrane dGTP catabolic process DNA replication DNA repair cellular response to DNA damage stimulus metabolic process zinc ion binding dGTPase activity deoxyribonucleotide catabolic process somatic hypermutation of immunoglobulin genes hydrolase activity triphosphoric monoester hydrolase activity dGTP binding site of double-strand break identical protein binding innate immune response regulation of innate immune response dATP catabolic process metal ion binding protein homotetramerization defense response to virus negative regulation of type I interferon-mediated signaling pathway RNA phosphodiester bond hydrolysis tetraspanin-enriched microdomain uc012chy.1 uc012chy.2 uc012chy.3 
ENSMUST00000057742.15 Cpne4 ENSMUST00000057742.15 copine IV, transcript variant 2 (from RefSeq NM_028719.3) CPNE4_MOUSE Cpne4 ENSMUST00000057742.1 ENSMUST00000057742.10 ENSMUST00000057742.11 ENSMUST00000057742.12 ENSMUST00000057742.13 ENSMUST00000057742.14 ENSMUST00000057742.2 ENSMUST00000057742.3 ENSMUST00000057742.4 ENSMUST00000057742.5 ENSMUST00000057742.6 ENSMUST00000057742.7 ENSMUST00000057742.8 ENSMUST00000057742.9 NM_028719 Q8BLR2 uc009rhr.1 uc009rhr.2 uc009rhr.3 Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts (via VWFA domain) with ACTB, BCOR, BICD2, CCDC22, CDC42BPB, CEP162, MYCBP2, NONO, PDCD6, PITPNM2, RDX, SKIL, SKT, SPTBN1, UBE2O and WTAP. Belongs to the copine family. protein binding calcium-dependent phospholipid binding plasma membrane cellular response to calcium ion uc009rhr.1 uc009rhr.2 uc009rhr.3 
ENSMUST00000057767.6 Upk1b ENSMUST00000057767.6 uroplakin 1B (from RefSeq NM_178924.4) ENSMUST00000057767.1 ENSMUST00000057767.2 ENSMUST00000057767.3 ENSMUST00000057767.4 ENSMUST00000057767.5 NM_178924 Q8C448 Q8K4M0 Q9Z2C6 UPK1B_MOUSE uc007zfm.1 uc007zfm.2 uc007zfm.3 uc007zfm.4 Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity). Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B). Membrane; Multi-pass membrane protein. Bladder epithelium. N-glycosylated with high-mannose oligosaccharides. Belongs to the tetraspanin (TM4SF) family. integral component of plasma membrane response to bacterium membrane integral component of membrane apical plasma membrane epithelial cell differentiation uc007zfm.1 uc007zfm.2 uc007zfm.3 uc007zfm.4 
ENSMUST00000057773.5 Mblac1 ENSMUST00000057773.5 metallo-beta-lactamase domain containing 1 (from RefSeq NM_177878.3) ENSMUST00000057773.1 ENSMUST00000057773.2 ENSMUST00000057773.3 ENSMUST00000057773.4 MBLC1_MOUSE Mblac1 NM_177878 Q8BWY4 Q8CHU7 uc009afa.1 uc009afa.2 uc009afa.3 Endoribonuclease that catalyzes the hydrolysis of histone- coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'- ACCCACA-3' sequence, respectively, and located downstream of the stem- loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage. Reaction=a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+); Xref=Rhea:RHEA:68096, Rhea:RHEA-COMP:15179, Rhea:RHEA-COMP:17355, Rhea:RHEA-COMP:17428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74896, ChEBI:CHEBI:138282, ChEBI:CHEBI:173118; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68097; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Homodimer. Cytoplasm, cytosol Nucleus Note=Localizes in the nucleus during early S-phase of the cell cycle. Contains four of the five characteristic MBL-fold metal-binding motifs, with two waters completing metal coordination. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. molecular_function cellular_component biological_process hydrolase activity metal ion binding uc009afa.1 uc009afa.2 uc009afa.3 
ENSMUST00000057781.8 Klhl31 ENSMUST00000057781.8 kelch-like 31 (from RefSeq NM_172925.2) ENSMUST00000057781.1 ENSMUST00000057781.2 ENSMUST00000057781.3 ENSMUST00000057781.4 ENSMUST00000057781.5 ENSMUST00000057781.6 ENSMUST00000057781.7 G3X9D8 G3X9D8_MOUSE Klhl31 NM_172925 uc009qtl.1 uc009qtl.2 uc009qtl.3 uc009qtl.4 negative regulation of protein phosphorylation nucleus cytoplasm membrane integral component of membrane negative regulation of JNK cascade uc009qtl.1 uc009qtl.2 uc009qtl.3 uc009qtl.4 
ENSMUST00000057783.6 Gpr22 ENSMUST00000057783.6 G protein-coupled receptor 22 (from RefSeq NM_175191.5) ENSMUST00000057783.1 ENSMUST00000057783.2 ENSMUST00000057783.3 ENSMUST00000057783.4 ENSMUST00000057783.5 GPR22_MOUSE NM_175191 Q80UE1 Q8BZL4 uc007nht.1 uc007nht.2 uc007nht.3 uc007nht.4 Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (By similarity). May be involved in ciliogenesis (By similarity). Cell membrane ; Multi-pass membrane protein Abundant levels detected in the brain and heart and no detectable expression in other peripheral tissues. Decreased expression in heart following aortic banding, a procedure that mimics cardiac hypertrophy produced by high blood pressure. No visible phenotype, however mice display increased susceptibility to heart failure under conditions of hemodynamic stress. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane cell projection organization uc007nht.1 uc007nht.2 uc007nht.3 uc007nht.4 
ENSMUST00000057792.9 Pon2 ENSMUST00000057792.9 paraoxonase 2 (from RefSeq NM_183308.3) ENSMUST00000057792.1 ENSMUST00000057792.2 ENSMUST00000057792.3 ENSMUST00000057792.4 ENSMUST00000057792.5 ENSMUST00000057792.6 ENSMUST00000057792.7 ENSMUST00000057792.8 NM_183308 PON2_MOUSE Q3TAD3 Q62086 Q8CFK3 uc009awf.1 uc009awf.2 uc009awf.3 Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Reaction=a phenyl acetate + H2O = a phenol + acetate + H(+); Xref=Rhea:RHEA:17309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:33853, ChEBI:CHEBI:140310; EC=3.1.1.2; Evidence=; Reaction=an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H(+); Xref=Rhea:RHEA:22576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:55474, ChEBI:CHEBI:58921; EC=3.1.1.81; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 calcium ions per subunit. ; Homotrimer. Membrane ; Peripheral membrane protein Glycosylated. The signal sequence is not cleaved. Belongs to the paraoxonase family. arylesterase activity extracellular region nucleus mitochondrion lysosome plasma membrane response to oxidative stress response to toxic substance membrane hydrolase activity aromatic compound catabolic process identical protein binding intracellular membrane-bounded organelle metal ion binding acyl-L-homoserine-lactone lactonohydrolase activity uc009awf.1 uc009awf.2 uc009awf.3 
ENSMUST00000057795.12 Rsrc2 ENSMUST00000057795.12 arginine/serine-rich coiled-coil 2, transcript variant 14 (from RefSeq NR_153361.1) A2RTL5 ENSMUST00000057795.1 ENSMUST00000057795.10 ENSMUST00000057795.11 ENSMUST00000057795.2 ENSMUST00000057795.3 ENSMUST00000057795.4 ENSMUST00000057795.5 ENSMUST00000057795.6 ENSMUST00000057795.7 ENSMUST00000057795.8 ENSMUST00000057795.9 NR_153361 RSRC2_MOUSE uc290zre.1 uc290zre.2 Belongs to the RSRC2 family. cellular_component biological_process uc290zre.1 uc290zre.2 
ENSMUST00000057799.8 Zfp867 ENSMUST00000057799.8 zinc finger protein 867 (from RefSeq NM_178417.3) E9Q2M4 E9Q2M4_MOUSE ENSMUST00000057799.1 ENSMUST00000057799.2 ENSMUST00000057799.3 ENSMUST00000057799.4 ENSMUST00000057799.5 ENSMUST00000057799.6 ENSMUST00000057799.7 NM_178417 Zfp867 uc007jdy.1 uc007jdy.2 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc007jdy.1 uc007jdy.2 
ENSMUST00000057801.8 Kcnj4 ENSMUST00000057801.8 potassium inwardly-rectifying channel, subfamily J, member 4 (from RefSeq NM_008427.5) ENSMUST00000057801.1 ENSMUST00000057801.2 ENSMUST00000057801.3 ENSMUST00000057801.4 ENSMUST00000057801.5 ENSMUST00000057801.6 ENSMUST00000057801.7 Kcnj4 NM_008427 Q8R435 Q8R435_MOUSE uc007wtn.1 uc007wtn.2 uc007wtn.3 Membrane ulti-pass membrane protein Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. inward rectifier potassium channel activity voltage-gated ion channel activity ion transport potassium ion transport membrane integral component of membrane basolateral plasma membrane PDZ domain binding ion transmembrane transport regulation of ion transmembrane transport potassium ion transmembrane transport uc007wtn.1 uc007wtn.2 uc007wtn.3 
ENSMUST00000057810.7 Psg23 ENSMUST00000057810.7 pregnancy-specific beta-1-glycoprotein 23 (from RefSeq NM_020261.4) ENSMUST00000057810.1 ENSMUST00000057810.2 ENSMUST00000057810.3 ENSMUST00000057810.4 ENSMUST00000057810.5 ENSMUST00000057810.6 NM_020261 Psg23 Q9D2U0 Q9D2U0_MOUSE uc009fjo.1 uc009fjo.2 cellular_component positive regulation of gene expression negative regulation of blood coagulation heparan sulfate proteoglycan binding uc009fjo.1 uc009fjo.2 
ENSMUST00000057814.5 Oas1f ENSMUST00000057814.5 2'-5' oligoadenylate synthetase 1F (from RefSeq NM_145153.3) ENSMUST00000057814.1 ENSMUST00000057814.2 ENSMUST00000057814.3 ENSMUST00000057814.4 NM_145153 Oas1f Q14AZ4 Q14AZ4_MOUSE uc008zig.1 uc008zig.2 uc008zig.3 Belongs to the 2-5A synthase family. RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm cytosol immune response transferase activity negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity 2'-5'-oligoadenylate synthetase activity uc008zig.1 uc008zig.2 uc008zig.3 
ENSMUST00000057816.15 Uckl1 ENSMUST00000057816.15 uridine-cytidine kinase 1-like 1, transcript variant 2 (from RefSeq NM_026765.3) ENSMUST00000057816.1 ENSMUST00000057816.10 ENSMUST00000057816.11 ENSMUST00000057816.12 ENSMUST00000057816.13 ENSMUST00000057816.14 ENSMUST00000057816.2 ENSMUST00000057816.3 ENSMUST00000057816.4 ENSMUST00000057816.5 ENSMUST00000057816.6 ENSMUST00000057816.7 ENSMUST00000057816.8 ENSMUST00000057816.9 NM_026765 Q91YL3 UCKL1_MOUSE Urkl1 uc008oms.1 uc008oms.2 uc008oms.3 uc008oms.4 uc008oms.5 May contribute to UTP accumulation needed for blast transformation and proliferation. Reaction=ATP + uridine = ADP + H(+) + UMP; Xref=Rhea:RHEA:16825, ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:30616, ChEBI:CHEBI:57865, ChEBI:CHEBI:456216; EC=2.7.1.48; Reaction=ATP + cytidine = ADP + CMP + H(+); Xref=Rhea:RHEA:24674, ChEBI:CHEBI:15378, ChEBI:CHEBI:17562, ChEBI:CHEBI:30616, ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.1.48; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. Interacts with RNF19B. Cytoplasm Nucleus Ubiquitinated by RNF19B; which induces proteasomal degradation. Belongs to the uridine kinase family. nucleotide binding uridine kinase activity ATP binding nucleus cytoplasm nucleoside metabolic process kinase activity phosphorylation transferase activity UMP salvage uc008oms.1 uc008oms.2 uc008oms.3 uc008oms.4 uc008oms.5 
ENSMUST00000057829.4 Mrpl50 ENSMUST00000057829.4 mitochondrial ribosomal protein L50 (from RefSeq NM_178603.4) ENSMUST00000057829.1 ENSMUST00000057829.2 ENSMUST00000057829.3 NM_178603 Q8VDT9 Q9CR44 RM50_MOUSE uc008svu.1 uc008svu.2 uc008svu.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mL50 family. molecular_function mitochondrion mitochondrial large ribosomal subunit ribosome biological_process uc008svu.1 uc008svu.2 uc008svu.3 
ENSMUST00000057831.8 Cilp2 ENSMUST00000057831.8 cartilage intermediate layer protein 2 (from RefSeq NM_026818.2) CILP2_MOUSE Cilp2 D3Z7H8 ENSMUST00000057831.1 ENSMUST00000057831.2 ENSMUST00000057831.3 ENSMUST00000057831.4 ENSMUST00000057831.5 ENSMUST00000057831.6 ENSMUST00000057831.7 NM_026818 uc009lyb.1 uc009lyb.2 uc009lyb.3 uc009lyb.4 May play a role in cartilage scaffolding. Secreted, extracellular space, extracellular matrix Expressed in articulated and meniscal cartilage (at protein level). Also detected in heart, skeletal muscle and brain. Not detected in growth plate cartilage. In the knee joint, detected in articular cartilage from 2 weeks of age but not at earlier stages (at protein level). Initially localizes to the surface zone of articular cartilage but by maturity (8 weeks) is found in the intermediate to deep zones (at protein level). May be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion. N-glycosylated. molecular_function extracellular region biological_process carbohydrate binding uc009lyb.1 uc009lyb.2 uc009lyb.3 uc009lyb.4 
ENSMUST00000057844.10 B230219D22Rik ENSMUST00000057844.10 RIKEN cDNA B230219D22 gene (from RefSeq NM_181278.2) CE024_MOUSE ENSMUST00000057844.1 ENSMUST00000057844.2 ENSMUST00000057844.3 ENSMUST00000057844.4 ENSMUST00000057844.5 ENSMUST00000057844.6 ENSMUST00000057844.7 ENSMUST00000057844.8 ENSMUST00000057844.9 NM_181278 Q80X32 Q8C2G2 uc007qrx.1 uc007qrx.2 Belongs to the UPF0461 family. Sequence=BAC40508.2; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc007qrx.1 uc007qrx.2 
ENSMUST00000057849.6 C1ql1 ENSMUST00000057849.6 complement component 1, q subcomponent-like 1 (from RefSeq NM_011795.3) A2AH89 C1QRF_MOUSE C1qrf Crf Ctrp14 ENSMUST00000057849.1 ENSMUST00000057849.2 ENSMUST00000057849.3 ENSMUST00000057849.4 ENSMUST00000057849.5 NM_011795 O88992 uc007lsz.1 uc007lsz.2 uc007lsz.3 uc007lsz.4 May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Interacts with ADGRB3 (PubMed:21262840). Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion (PubMed:23449976). Secreted. Expressed in brainstem. More abundant in areas of the nervous system involved in motor function, such as the Purkinje cells of the cerebellum, the accessory olivary nucleus, the pons and the red nucleus. receptor binding protein binding extracellular region collagen trimer cytoplasm neuron remodeling synaptic cleft climbing fiber motor learning presynapse maintenance of synapse structure uc007lsz.1 uc007lsz.2 uc007lsz.3 uc007lsz.4 
ENSMUST00000057855.4 Exoc3l ENSMUST00000057855.4 exocyst complex component 3-like, transcript variant 1 (from RefSeq NM_177788.5) ENSMUST00000057855.1 ENSMUST00000057855.2 ENSMUST00000057855.3 EX3L1_MOUSE Exoc3l1 NM_177788 Q3USB8 Q8BI71 uc009nci.1 uc009nci.2 As part of the exocyst, may play a role in regulated exocytosis of insulin granules. Interacts with EXOC2, EXOC4 and EXOC5; may be part of the exocyst. Cytoplasmic vesicle, secretory vesicle Note=Colocalizes with insulin granules. Ubiquitously expressed. Belongs to the SEC6 family. exocyst SNARE binding protein binding exocytosis peptide hormone secretion transport vesicle secretory granule cytoplasmic vesicle exocyst localization uc009nci.1 uc009nci.2 
ENSMUST00000057859.9 Frmd6 ENSMUST00000057859.9 FERM domain containing 6, transcript variant 2 (from RefSeq NM_028127.4) ENSMUST00000057859.1 ENSMUST00000057859.2 ENSMUST00000057859.3 ENSMUST00000057859.4 ENSMUST00000057859.5 ENSMUST00000057859.6 ENSMUST00000057859.7 ENSMUST00000057859.8 FRMD6_MOUSE NM_028127 Q8BW34 Q8C0V9 uc007ntv.1 uc007ntv.2 Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Can colocalize with actin. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C0V9-1; Sequence=Displayed; Name=2; IsoId=Q8C0V9-2; Sequence=VSP_008024, VSP_008025, VSP_008026; Name=3; IsoId=Q8C0V9-3; Sequence=VSP_008026, VSP_008027, VSP_008028; apical constriction protein binding cytoplasm cytoskeleton plasma membrane membrane actomyosin structure organization regulation of actin filament-based process cellular protein localization apical junction complex uc007ntv.1 uc007ntv.2 
ENSMUST00000057860.3 Pdha2 ENSMUST00000057860.3 pyruvate dehydrogenase E1 alpha 2 (from RefSeq NM_008811.2) ENSMUST00000057860.1 ENSMUST00000057860.2 NM_008811 ODPAT_MOUSE P35487 Pdha-2 Pdhal Q497M8 uc008rob.1 uc008rob.2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Reaction=H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate = CO2 + N(6)-[(R)-S(8)- acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase]; Xref=Rhea:RHEA:19189, Rhea:RHEA-COMP:10480, Rhea:RHEA-COMP:10481, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:83099, ChEBI:CHEBI:83111; EC=1.2.4.1; Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Pyruvate dehydrogenase activity is inhibited by phosphorylation of PDHA2; it is reactivated by dephosphorylation. Heterotetramer of two PDHA2 and two PDHB subunits. The heterotetramer interacts with DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (By similarity). Mitochondrion matrix Testis. pyruvate dehydrogenase (acetyl-transferring) activity nucleolus mitochondrion mitochondrial matrix carbohydrate metabolic process glucose metabolic process acetyl-CoA biosynthetic process from pyruvate pyruvate metabolic process tricarboxylic acid cycle oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor intracellular membrane-bounded organelle pyruvate dehydrogenase complex oxidation-reduction process mitochondrial acetyl-CoA biosynthetic process from pyruvate pyruvate dehydrogenase (NAD+) activity uc008rob.1 uc008rob.2 
ENSMUST00000057866.13 Nrsn1 ENSMUST00000057866.13 neurensin 1, transcript variant 1 (from RefSeq NM_009513.2) ENSMUST00000057866.1 ENSMUST00000057866.10 ENSMUST00000057866.11 ENSMUST00000057866.12 ENSMUST00000057866.2 ENSMUST00000057866.3 ENSMUST00000057866.4 ENSMUST00000057866.5 ENSMUST00000057866.6 ENSMUST00000057866.7 ENSMUST00000057866.8 ENSMUST00000057866.9 NM_009513 NRSN1_MOUSE Nrsn1 P97799 Vmp uc007pwx.1 uc007pwx.2 uc007pwx.3 uc007pwx.4 May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth (PubMed:12445626, PubMed:16527258, PubMed:16696124, PubMed:9191101). May play a role in neurite extension (PubMed:26430118). Membrane ; Multi-pass membrane protein Cell projection, neuron projection Expressed predominantly in brain. Also weakly expressed in lung and spleen. In brain, expressed strongly in nerve fibers of the cerebral cortex, anterior cerebral nuclei, hypothalamus, amygdaloid complex, brain stem of the metaencephalon and medulla oblongata, and moderately expressed in soma of neurons of the dentate gyrus of the hippocampus and Purkinje cells of the cerebellum. Expression is developmentally regulated as axonal fibers innervate, extend collateral fibers and finally attain a stable state. First detected at postnatal day 6 in cell bodies and apical dendrites of pyramidal neurons in the developing cerebral cortex, with expression gradually increasing during postnatal development. In P1 retina, strongly expressed in the optic nerve fiber layer, and weakly expressed in ganglion cells, presumptive amacrine and horizontal cells. At P10, also strongly expressed in other parts of the retina such as the ganglion cells, inner plexiform layer and horizontal cells. Expression decreases as the retina develops further to maturity. By retinoic acid in neuroblastoma Neuro2a cells. Down- regulated following fear conditioning (at protein level) (PubMed:26430118). Belongs to the VMP family. molecular_function nervous system development membrane integral component of membrane transport vesicle growth cone cytoplasmic vesicle neuron projection neuronal cell body uc007pwx.1 uc007pwx.2 uc007pwx.3 uc007pwx.4 
ENSMUST00000057870.4 Rprml ENSMUST00000057870.4 reprimo-like (from RefSeq NM_001033212.2) ENSMUST00000057870.1 ENSMUST00000057870.2 ENSMUST00000057870.3 NM_001033212 Q3URD2 RPRML_MOUSE uc007lvn.1 uc007lvn.2 uc007lvn.3 Membrane ; Single-pass membrane protein Belongs to the reprimo family. molecular_function cellular_component biological_process membrane integral component of membrane uc007lvn.1 uc007lvn.2 uc007lvn.3 
ENSMUST00000057885.13 Rpl9 ENSMUST00000057885.13 ribosomal protein L9 (from RefSeq NM_011292.2) ENSMUST00000057885.1 ENSMUST00000057885.10 ENSMUST00000057885.11 ENSMUST00000057885.12 ENSMUST00000057885.2 ENSMUST00000057885.3 ENSMUST00000057885.4 ENSMUST00000057885.5 ENSMUST00000057885.6 ENSMUST00000057885.7 ENSMUST00000057885.8 ENSMUST00000057885.9 NM_011292 Q5EBQ6 Q5EBQ6_MOUSE Rpl9 uc008xnp.1 uc008xnp.2 uc008xnp.3 uc008xnp.4 Component of the large ribosomal subunit. Cytoplasm Belongs to the universal ribosomal protein uL6 family. structural constituent of ribosome ribosome translation rRNA binding uc008xnp.1 uc008xnp.2 uc008xnp.3 uc008xnp.4 
ENSMUST00000057889.8 A730035I17Rik ENSMUST00000057889.8 RIKEN cDNA A730035I17 gene (from RefSeq NR_153823.1) ENSMUST00000057889.1 ENSMUST00000057889.2 ENSMUST00000057889.3 ENSMUST00000057889.4 ENSMUST00000057889.5 ENSMUST00000057889.6 ENSMUST00000057889.7 NR_153823 uc290xiw.1 uc290xiw.2 uc290xiw.1 uc290xiw.2 
ENSMUST00000057893.7 Fzd2 ENSMUST00000057893.7 frizzled class receptor 2 (from RefSeq NM_020510.2) ENSMUST00000057893.1 ENSMUST00000057893.2 ENSMUST00000057893.3 ENSMUST00000057893.4 ENSMUST00000057893.5 ENSMUST00000057893.6 FZD2_MOUSE Fzd10 NM_020510 Q810M0 Q9JIP5 Q9JIP6 Q9WUJ2 uc011yft.1 uc011yft.2 uc011yft.3 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Membrane; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein Expressed in embryonic and adult heart, lung, chondrocytes and brain. Also expressed in the developing gastrointestinal tract (strongest in foregut), much weaker expression in the adult. No expression in fetal liver and adult spleen. Up- regulated in esophageal squamous cell carcinomas. Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. The FZ domain is involved in binding with Wnt ligands. Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. Belongs to the G-protein coupled receptor Fz/Smo family. membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis transmembrane signaling receptor activity G-protein coupled receptor activity protein binding cytoplasm plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger positive regulation of cytosolic calcium ion concentration Wnt signaling pathway, calcium modulating pathway cell-cell signaling multicellular organism development sensory perception of smell membrane integral component of membrane Wnt signaling pathway Wnt-protein binding PDZ domain binding epithelial cell differentiation non-canonical Wnt signaling pathway identical protein binding Wnt-activated receptor activity positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of transcription, DNA-templated protein heterodimerization activity positive regulation of sequence-specific DNA binding transcription factor activity hard palate development canonical Wnt signaling pathway inner ear receptor cell development ventricular septum morphogenesis cochlea morphogenesis planar cell polarity pathway involved in neural tube closure uc011yft.1 uc011yft.2 uc011yft.3 
ENSMUST00000057896.5 Gxylt1 ENSMUST00000057896.5 glucoside xylosyltransferase 1, transcript variant 2 (from RefSeq NM_001346785.1) D3Z6W7 D3Z6W7_MOUSE ENSMUST00000057896.1 ENSMUST00000057896.2 ENSMUST00000057896.3 ENSMUST00000057896.4 Gxylt1 NM_001346785 uc057kuo.1 uc057kuo.2 uc057kuo.3 Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose. Reaction=3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP- alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L- seryl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:56064, Rhea:RHEA-COMP:14610, Rhea:RHEA-COMP:14611, ChEBI:CHEBI:15378, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:140575, ChEBI:CHEBI:140576; EC=2.4.2.42; Evidence=; Membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 8 family. O-glycan processing transferase activity transferase activity, transferring glycosyl groups UDP-xylosyltransferase activity uc057kuo.1 uc057kuo.2 uc057kuo.3 
ENSMUST00000057907.10 Fbxo44 ENSMUST00000057907.10 F-box protein 44, transcript variant 1 (from RefSeq NM_173401.5) A2A7H5 A2A7H5_MOUSE ENSMUST00000057907.1 ENSMUST00000057907.2 ENSMUST00000057907.3 ENSMUST00000057907.4 ENSMUST00000057907.5 ENSMUST00000057907.6 ENSMUST00000057907.7 ENSMUST00000057907.8 ENSMUST00000057907.9 Fbxo44 NM_173401 uc008vug.1 uc008vug.2 uc008vug.3 uc008vug.4 uc008vug.5 uc008vug.1 uc008vug.2 uc008vug.3 uc008vug.4 uc008vug.5 
ENSMUST00000057910.16 Rexo1 ENSMUST00000057910.16 REX1, RNA exonuclease 1 (from RefSeq NM_025852.4) ENSMUST00000057910.1 ENSMUST00000057910.10 ENSMUST00000057910.11 ENSMUST00000057910.12 ENSMUST00000057910.13 ENSMUST00000057910.14 ENSMUST00000057910.15 ENSMUST00000057910.2 ENSMUST00000057910.3 ENSMUST00000057910.4 ENSMUST00000057910.5 ENSMUST00000057910.6 ENSMUST00000057910.7 ENSMUST00000057910.8 ENSMUST00000057910.9 Kiaa1138 NM_025852 Q3UMP1 Q69ZR0 Q6NSQ6 Q6PI95 Q7TT28 Q9DA29 REXO1_MOUSE Tceb3bp1 uc007gds.1 uc007gds.2 uc007gds.3 Seems to have no detectable effect on transcription elongation in vitro. Interacts with TCEA2 and ELOA. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TT28-1; Sequence=Displayed; Name=2; IsoId=Q7TT28-2; Sequence=VSP_019121, VSP_019122, VSP_019123; [Isoform 2]: May be due to an intron retention. Belongs to the REXO1/REXO3 family. Sequence=BAD32386.1; Type=Erroneous initiation; Evidence=; nucleic acid binding nuclease activity exonuclease activity nucleus nucleoplasm biological_process nuclear body hydrolase activity nucleic acid phosphodiester bond hydrolysis uc007gds.1 uc007gds.2 uc007gds.3 
ENSMUST00000057920.7 Mtnr1b ENSMUST00000057920.7 melatonin receptor 1B (from RefSeq NM_145712.2) ENSMUST00000057920.1 ENSMUST00000057920.2 ENSMUST00000057920.3 ENSMUST00000057920.4 ENSMUST00000057920.5 ENSMUST00000057920.6 Mtnr1b NM_145712 Q3SXF8 Q3SXF8_MOUSE uc292erc.1 uc292erc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity cell signal transduction G-protein coupled receptor signaling pathway melatonin receptor activity negative regulation of cGMP-mediated signaling membrane integral component of membrane glucose homeostasis positive regulation of circadian rhythm camera-type eye development negative regulation of neuron apoptotic process positive regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of insulin secretion regulation of insulin secretion negative regulation of cytosolic calcium ion concentration negative regulation of transmission of nerve impulse positive regulation of transmission of nerve impulse regulation of neuronal action potential negative regulation of delayed rectifier potassium channel activity uc292erc.1 uc292erc.2 
ENSMUST00000057921.10 Arf2 ENSMUST00000057921.10 ADP-ribosylation factor 2, transcript variant 2 (from RefSeq NM_001304574.1) ARF2_MOUSE ENSMUST00000057921.1 ENSMUST00000057921.2 ENSMUST00000057921.3 ENSMUST00000057921.4 ENSMUST00000057921.5 ENSMUST00000057921.6 ENSMUST00000057921.7 ENSMUST00000057921.8 ENSMUST00000057921.9 NM_001304574 P10947 P16500 Q3TJ37 Q8BSL7 Q91VR9 uc007lvx.1 uc007lvx.2 uc007lvx.3 uc007lvx.4 GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Golgi apparatus. Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTP binding cytoplasm Golgi apparatus plasma membrane intracellular protein transport protein transport vesicle-mediated transport uc007lvx.1 uc007lvx.2 uc007lvx.3 uc007lvx.4 
ENSMUST00000057927.10 Rasip1 ENSMUST00000057927.10 Ras interacting protein 1 (from RefSeq NM_028544.1) E9QLI7 ENSMUST00000057927.1 ENSMUST00000057927.2 ENSMUST00000057927.3 ENSMUST00000057927.4 ENSMUST00000057927.5 ENSMUST00000057927.6 ENSMUST00000057927.7 ENSMUST00000057927.8 ENSMUST00000057927.9 NM_028544 Q3U0S6 Q6GQW4 RAIN_MOUSE uc009gwi.1 uc009gwi.2 uc009gwi.3 Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy (By similarity). Interacts with Ras family members that have been activated by GTP binding. Interacts with HRAS, RAP1A, RAP2, RRAS, RAF1 and RRAS2 (By similarity). Interacts with MYH9 and ARHGAP29. Cytoplasm, perinuclear region Golgi apparatus, Golgi stack Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS (By similarity). Detected in kidney, heart, skeletal muscle, small intestine and lung. Specifically expressed in the endothelium of the developing blood vessels in embryos. angiogenesis vasculogenesis protein binding cytoplasm Golgi apparatus Golgi stack cell-cell junction signal transduction positive regulation of cell proliferation negative regulation of autophagy Ras GTPase binding macromolecular complex positive regulation of integrin activation negative regulation of Rho protein signal transduction protein homodimerization activity regulation of GTPase activity perinuclear region of cytoplasm branching morphogenesis of an epithelial tube GTPase binding negative regulation of membrane permeability negative regulation of Rho-dependent protein serine/threonine kinase activity uc009gwi.1 uc009gwi.2 uc009gwi.3 
ENSMUST00000057932.8 Slurp2 ENSMUST00000057932.8 secreted Ly6/Plaur domain containing 2 (from RefSeq NM_001081961.1) ENSMUST00000057932.1 ENSMUST00000057932.2 ENSMUST00000057932.3 ENSMUST00000057932.4 ENSMUST00000057932.5 ENSMUST00000057932.6 ENSMUST00000057932.7 NM_001081961 P0DP59 Q08EF7 Q3TRB5 Q9WVC2 SLUR2_MOUSE Slurp2 uc007wfv.1 uc007wfv.2 uc007wfv.3 Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs, strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7- containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha- 3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner. Interacts with CHRNA3, CHRNA4, CHRNA5, CHRNA7, CHRNB2 and CHRNB4. Interacts with CHRM1 and CHRM3 probably in an allosteric manner (By similarity). Secreted Widely expressed, including in dendritic cells, macrophages, B- and T-lymphocytes. extracellular region extracellular space plasma membrane membrane acetylcholine receptor regulator activity acetylcholine receptor inhibitor activity acetylcholine receptor binding keratinocyte proliferation acetylcholine receptor signaling pathway regulation of neurotransmitter receptor activity negative regulation of receptor activity uc007wfv.1 uc007wfv.2 uc007wfv.3 
ENSMUST00000057934.10 Tcf25 ENSMUST00000057934.10 transcription factor 25 (basic helix-loop-helix), transcript variant 3 (from RefSeq NM_001037878.5) D8Ertd325e ENSMUST00000057934.1 ENSMUST00000057934.2 ENSMUST00000057934.3 ENSMUST00000057934.4 ENSMUST00000057934.5 ENSMUST00000057934.6 ENSMUST00000057934.7 ENSMUST00000057934.8 ENSMUST00000057934.9 NM_001037878 Nulp1 Q3THR8 Q3UBI7 Q3UD64 Q3UG75 Q80ZX3 Q8BR80 Q8C200 Q8C2M3 Q8C6B4 Q8R3L2 Q9CUW0 Q9ER19 TCF25_MOUSE uc009nvl.1 uc009nvl.2 uc009nvl.3 uc009nvl.4 Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (By similarity). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (By similarity). Also acts as a transcriptional repressor: represses transcription of SRF in vitro and so may play a role in heart development (By similarity). May play a role in cell death control (PubMed:18068114). Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase LTN1, TCF25 and NEMF associated with the 60S ribosomal subunit (By similarity). Interacts with XIAP (PubMed:18068114). Nucleus toplasm, cytosol Note=Mainly nuclear. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8R3L2-1; Sequence=Displayed; Name=2; IsoId=Q8R3L2-2; Sequence=VSP_020026, VSP_020027; Name=3; IsoId=Q8R3L2-3; Sequence=VSP_020023, VSP_020025, VSP_020028; Name=4; IsoId=Q8R3L2-4; Sequence=VSP_020024, VSP_020026, VSP_020027; Name=5; IsoId=Q8R3L2-5; Sequence=VSP_020025, VSP_020028; Broadly expressed in the embryo during the early stages of organogenesis with highest levels in dorsal root ganglia and little or no expression in liver and skin. The C-terminal region mediates transcriptional repression. Belongs to the TCF25 family. Sequence=BAB28983.2; Type=Erroneous initiation; Evidence=; Sequence=BAC32344.1; Type=Frameshift; Evidence=; Sequence=BAC36220.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter DNA binding transcription factor activity, sequence-specific DNA binding nucleus uc009nvl.1 uc009nvl.2 uc009nvl.3 uc009nvl.4 
ENSMUST00000057942.4 Mc4r ENSMUST00000057942.4 melanocortin 4 receptor (from RefSeq NM_016977.4) ENSMUST00000057942.1 ENSMUST00000057942.2 ENSMUST00000057942.3 MC4R_MOUSE NM_016977 P56450 Q49NR4 Q9EQM7 uc008ffv.1 uc008ffv.2 uc008ffv.3 uc008ffv.4 uc008ffv.5 This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased cholesterol levels and insulin resistance. [provided by RefSeq, Dec 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK136793.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). Interacts with ATRNL1. Homodimer; disulfide-linked, also forms higher order oligomers. Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS- binding and thus inhibits agonist-induced cAMP production (By similarity). Interacts with MRAP and MRAP2; these associated factors increase ligand-sensitivity and generation of cAMP. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. diet induced thermogenesis G-protein coupled receptor activity melanocortin receptor activity melanocyte-stimulating hormone receptor activity protein binding nucleus plasma membrane energy reserve metabolic process signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway feeding behavior membrane integral component of membrane peptide hormone binding regulation of metabolic process insulin secretion ubiquitin protein ligase binding response to insulin hormone binding neuropeptide binding positive regulation of bone resorption regulation of feeding behavior negative regulation of feeding behavior regulation of grooming behavior uc008ffv.1 uc008ffv.2 uc008ffv.3 uc008ffv.4 uc008ffv.5 
ENSMUST00000057944.12 Ugt8a ENSMUST00000057944.12 UDP galactosyltransferase 8A, transcript variant 2 (from RefSeq NR_149311.1) CGT_MOUSE Cgt ENSMUST00000057944.1 ENSMUST00000057944.10 ENSMUST00000057944.11 ENSMUST00000057944.2 ENSMUST00000057944.3 ENSMUST00000057944.4 ENSMUST00000057944.5 ENSMUST00000057944.6 ENSMUST00000057944.7 ENSMUST00000057944.8 ENSMUST00000057944.9 NR_149311 Q61634 Q64676 Q91W57 Ugt4 Ugt8 uc008rfz.1 uc008rfz.2 uc008rfz.3 Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides. Reaction=an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D- galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP; Xref=Rhea:RHEA:13093, ChEBI:CHEBI:15378, ChEBI:CHEBI:18390, ChEBI:CHEBI:52639, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914; EC=2.4.1.47; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13094; Evidence=; Reaction=N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP; Xref=Rhea:RHEA:43400, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:83244, ChEBI:CHEBI:83246; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43401; Evidence=; Reaction=N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP; Xref=Rhea:RHEA:43404, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:83248, ChEBI:CHEBI:83257; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43405; Evidence=; Reaction=an N-acyl-sphingoid base + UDP-alpha-D-galactose = a D- galactosylceramide + H(+) + UDP; Xref=Rhea:RHEA:48344, ChEBI:CHEBI:15378, ChEBI:CHEBI:36498, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:83273; Evidence=; Sphingolipid metabolism; galactosylceramide biosynthesis. Membrane ; Single- pass membrane protein Endoplasmic reticulum Belongs to the UDP-glycosyltransferase family. protein localization to paranode region of axon lipid metabolic process sphingolipid metabolic process galactosylceramide biosynthetic process cytoskeleton organization ceramide glucosyltransferase activity UDP-glycosyltransferase activity UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity glycolipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups paranodal junction assembly myelination intracellular membrane-bounded organelle N-acylsphingosine galactosyltransferase activity neuron projection morphogenesis uc008rfz.1 uc008rfz.2 uc008rfz.3 
ENSMUST00000057975.8 Bbs12 ENSMUST00000057975.8 Bardet-Biedl syndrome 12, transcript variant 1 (from RefSeq NM_001008502.2) A2AGT2 BBS12_MOUSE ENSMUST00000057975.1 ENSMUST00000057975.2 ENSMUST00000057975.3 ENSMUST00000057975.4 ENSMUST00000057975.5 ENSMUST00000057975.6 ENSMUST00000057975.7 Gm1805 NM_001008502 Q5SUD9 uc008pao.1 uc008pao.2 uc008pao.3 Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation. Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with MKKS. Cell projection, cilium Note=Located within the basal body of the primary cilium of differentiating preadipocytes. Belongs to the TCP-1 chaperonin family. BBS12 subfamily. Sequence=CAI26237.1; Type=Erroneous initiation; Evidence=; Sequence=CAM14822.1; Type=Erroneous initiation; Evidence=; ATP binding cilium intraciliary transport eating behavior cell projection photoreceptor cell maintenance negative regulation of fat cell differentiation chaperone-mediated protein complex assembly uc008pao.1 uc008pao.2 uc008pao.3 
ENSMUST00000057977.4 A730049H05Rik ENSMUST00000057977.4 RIKEN cDNA A730049H05 gene (from RefSeq NR_169152.1) ENSMUST00000057977.1 ENSMUST00000057977.2 ENSMUST00000057977.3 NR_169152 uc009czd.1 uc009czd.2 uc009czd.3 uc009czd.1 uc009czd.2 uc009czd.3 
ENSMUST00000058004.4 Galr3 ENSMUST00000058004.4 galanin receptor 3 (from RefSeq NM_015738.2) A2RS28 E9QPX7 ENSMUST00000058004.1 ENSMUST00000058004.2 ENSMUST00000058004.3 GALR3_MOUSE Galnr3 NM_015738 O88853 uc007wsg.1 uc007wsg.2 uc007wsg.3 Receptor for the hormone galanin and spexin-1. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity galanin receptor activity plasma membrane integral component of plasma membrane cilium signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger negative regulation of adenylate cyclase activity neuropeptide signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane peptide hormone binding positive regulation of transcription from RNA polymerase II promoter galanin-activated signaling pathway non-motile cilium uc007wsg.1 uc007wsg.2 uc007wsg.3 
ENSMUST00000058007.7 Rxfp3 ENSMUST00000058007.7 relaxin family peptide receptor 3 (from RefSeq NM_178717.3) ENSMUST00000058007.1 ENSMUST00000058007.2 ENSMUST00000058007.3 ENSMUST00000058007.4 ENSMUST00000058007.5 ENSMUST00000058007.6 NM_178717 Q8BGE9 RL3R1_MOUSE Rln3r1 Salpr uc007vgy.1 uc007vgy.2 uc007vgy.3 Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane positive regulation of cytokinesis positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway uc007vgy.1 uc007vgy.2 uc007vgy.3 
ENSMUST00000058011.8 Mcm2 ENSMUST00000058011.8 minichromosome maintenance complex component 2 (from RefSeq NM_008564.2) Bm28 Cdcl1 ENSMUST00000058011.1 ENSMUST00000058011.2 ENSMUST00000058011.3 ENSMUST00000058011.4 ENSMUST00000058011.5 ENSMUST00000058011.6 ENSMUST00000058011.7 Kiaa0030 MCM2_MOUSE Mcmd2 NM_008564 O08971 O89057 P97310 Q8C2R0 uc009cvx.1 uc009cvx.2 uc009cvx.3 Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division (PubMed:10567526). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7- MCM3-MCM5 (By similarity). Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex (By similarity). Interacts with DBF4 (PubMed:10517317). Interacts with KAT7 (PubMed:11278932). May interact with MCM10 (By similarity). Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR (By similarity). Forms a co-chaperone complex with DNAJC9 and histone H3.3-H4 heterodimers (By similarity). Within the complex, interacts (via N-terminus) with DNAJC9 (via C-terminus); the interaction is histone-dependent (By similarity). Nucleus Chromosome Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex. Phosphorylation by the CDC7- DBF4 complex during G1/S phase is required for the initiation of DNA replication (By similarity). Acetylated by MCM3AP. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex. Belongs to the MCM family. Sequence=BAC97849.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding double-strand break repair via break-induced replication chromatin DNA binding DNA helicase activity DNA replication origin binding single-stranded DNA binding helicase activity ATP binding nucleus nucleoplasm nuclear origin of replication recognition complex cytoplasm DNA replication pre-replicative complex assembly involved in nuclear cell cycle DNA replication DNA unwinding involved in DNA replication DNA replication initiation nucleosome assembly apoptotic process cell cycle microtubule cytoskeleton hydrolase activity enzyme binding histone binding MCM complex metal ion binding cellular response to interleukin-4 cochlea development mitotic DNA replication initiation negative regulation of DNA helicase activity single-stranded DNA-dependent ATP-dependent DNA helicase activity 3'-5' DNA helicase activity uc009cvx.1 uc009cvx.2 uc009cvx.3 
ENSMUST00000058022.6 Tpcn2 ENSMUST00000058022.6 two pore segment channel 2, transcript variant 1 (from RefSeq NM_146206.6) ENSMUST00000058022.1 ENSMUST00000058022.2 ENSMUST00000058022.3 ENSMUST00000058022.4 ENSMUST00000058022.5 NM_146206 Q6NSV0 Q8BTJ7 Q8BWC0 Q8R396 TPC2_MOUSE Tpc2 Tpcn2 uc009kqx.1 uc009kqx.2 uc009kqx.3 Intracellular channel initially characterized as a non- selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5- bisphosphate) (PubMed:19387438, PubMed:20495006, PubMed:20547763, PubMed:25144390, PubMed:27231233). Localizes to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis. Is associated with a plethora of physiological processes, including mTOR-dependent nutrient sensing, skin pigmentation and autophagy (PubMed:25144390, PubMed:23394946, PubMed:23063126). Ion selectivity is not fixed but rather agonist- dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2. As calcium channel, it increases the pH in the lysosomal lumen, as sodium channel, it promotes lysosomal exocytosis (PubMed:32167471). Plays a crucial role in endolysosomal trafficking in the endolysosomal degradation pathway and is potentially involved in the homeostatic control of many macromolecules and cell metabolites (PubMed:25144390, PubMed:19387438, PubMed:20495006, PubMed:20547763, PubMed:23063126, PubMed:23394946, PubMed:32167471). Also expressed in melanosomes of pigmented cells where mediates a Ca(2+) channel and/or PI(3,5)P2-activated melanosomal Na(+) channel to acidify pH and inhibit tyrosinase activity required for melanogenesis and pigmentation (PubMed:27231233). Unlike the voltage-dependent TPCN1, TPCN2 is voltage independent and can be activated solely by PI(3,5)P2 binding. In contrast, PI(4,5)P2, PI(3,4)P2, PI(3)P and PI(5)P have no obvious effect on channel activation (By similarity). (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671, ChEBI:CHEBI:29108; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29673; Evidence=; Reaction=Na(+)(in) = Na(+)(out); Xref=Rhea:RHEA:34963, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:34965; Evidence=; Regulated by Mg(2+) ions, cytosolic Mg(2+) selectively inhibits outward current while lysosomal Mg(2+) modestly inhibits both the outward and inward currents. In the absence of Mg(2+), NAADP readily activates TPCN2, with properties similar to PI(3,5)P2 (By similarity). Na(+) current is inhibited by ATP in a MTORC-dependent manner. ATP sensitivity is independent of PI(3,5)P2 (PubMed:23394946). Both current elicited by PI(3,5)P2 as well as NAADP are inhibited by tetrandrine. Homodimer (Probable). Interacts with LRRK2. Interacts with HAX1. Interacts with MTOR; the interaction is required for TPCN2 ATP sensitivity (By similarity). Found in a complex with LSM12, TPCN1 and TPCN2 (By similarity). Interacts with LSM12 (By similarity). Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ulti-pass membrane protein Melanosome membrane ; Multi-pass membrane protein Note=Only the acidic lysosomal fraction is sensitive to NAADP. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BWC0-1; Sequence=Displayed; Name=2; IsoId=Q8BWC0-2; Sequence=VSP_023009, VSP_023010; Name=3; IsoId=Q8BWC0-3; Sequence=VSP_023008; Widely expressed. Highly expressed in macrophages (PubMed:32167471). Expressed in pigmented cells (PubMed:27231233). Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage- sensor and are characterized by a series of positively charged amino acids at every third position (By similarity). N-glycosylated. Loss of NAADP-mediated calcium release (PubMed:19387438). Mutant mice are highly susceptible to hepatic cholesterol overload, have hyperlipoproteinaemia and liver damage consistent with non-alcoholic fatty liver hepatitis (PubMed:25144390). TPCN1 and TPCN2 double knockouts are viable, fertile, have no obvious morphological abnormalities, and no obvious behavioral defects. After fasting for 3 days, they are less active and endurance performance is reduced by 8.3 fold in contrast to wild-type littermates that show no changes. Two days after re-introduction of food, mutants regain endurance and become as active as before fasting (PubMed:23394946). Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. Sequence=BAC41072.1; Type=Frameshift; Evidence=; ion channel activity voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity lysosome lysosomal membrane ion transport calcium ion transport cellular calcium ion homeostasis smooth muscle contraction lysosome organization endosome membrane regulation of autophagy membrane integral component of membrane calcium-mediated signaling protein kinase binding response to vitamin D regulation of ion transmembrane transport identical protein binding release of sequestered calcium ion into cytosol transmembrane transport calcium ion transmembrane transport NAADP-sensitive calcium-release channel activity uc009kqx.1 uc009kqx.2 uc009kqx.3 
ENSMUST00000058030.10 Mtap ENSMUST00000058030.10 methylthioadenosine phosphorylase (from RefSeq NM_024433.2) ENSMUST00000058030.1 ENSMUST00000058030.2 ENSMUST00000058030.3 ENSMUST00000058030.4 ENSMUST00000058030.5 ENSMUST00000058030.6 ENSMUST00000058030.7 ENSMUST00000058030.8 ENSMUST00000058030.9 MTAP_MOUSE NM_024433 Q3TJS4 Q9CQ65 uc008tof.1 uc008tof.2 uc008tof.3 uc008tof.4 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. Reaction=phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5- thio-alpha-D-ribose 1-phosphate; Xref=Rhea:RHEA:11852, ChEBI:CHEBI:16708, ChEBI:CHEBI:17509, ChEBI:CHEBI:43474, ChEBI:CHEBI:58533; EC=2.4.2.28; Evidence= Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'- thioadenosine (phosphorylase route): step 1/1. Homotrimer. Cytoplasm. Nucleus Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. catalytic activity nucleus cytoplasm cytosol purine ribonucleoside salvage nucleoside metabolic process transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups S-methyl-5-thioadenosine phosphorylase activity L-methionine biosynthetic process from methylthioadenosine methylation uc008tof.1 uc008tof.2 uc008tof.3 uc008tof.4 
ENSMUST00000058045.5 Garem2 ENSMUST00000058045.5 GRB2 associated regulator of MAPK1 subtype 2 (from RefSeq NM_001167879.1) ENSMUST00000058045.1 ENSMUST00000058045.2 ENSMUST00000058045.3 ENSMUST00000058045.4 Fam59b GARE2_MOUSE Gareml Gm444 NM_001167879 Q14CH4 Q6PAJ3 uc012dtz.1 uc012dtz.2 uc012dtz.3 Probable adapter protein that provides a critical link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PAJ3-1; Sequence=Displayed; Name=2; IsoId=Q6PAJ3-2; Sequence=VSP_034202, VSP_034203, VSP_034204; Belongs to the GAREM family. molecular_function biological_process uc012dtz.1 uc012dtz.2 uc012dtz.3 
ENSMUST00000058056.2 Il1f10 ENSMUST00000058056.2 interleukin 1 family, member 10, transcript variant 2 (from RefSeq NM_153077.3) ENSMUST00000058056.1 IL1FA_MOUSE NM_153077 Q8R459 uc008iou.1 uc008iou.2 Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T- cells in response to heat-killed Candida albicans. Reduces IL36G- induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2 (By similarity). Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Cytoplasm Endoplasmic reticulum-Golgi intermediate compartment Secreted Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. Belongs to the IL-1 family. cytokine activity interleukin-1 receptor binding extracellular region extracellular space inflammatory response immune response cytokine-mediated signaling pathway neutrophil chemotaxis positive regulation of interleukin-6 production positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade cellular response to lipopolysaccharide uc008iou.1 uc008iou.2 
ENSMUST00000058060.14 Bod1 ENSMUST00000058060.14 biorientation of chromosomes in cell division 1 (from RefSeq NM_001024919.1) BOD1_MOUSE ENSMUST00000058060.1 ENSMUST00000058060.10 ENSMUST00000058060.11 ENSMUST00000058060.12 ENSMUST00000058060.13 ENSMUST00000058060.2 ENSMUST00000058060.3 ENSMUST00000058060.4 ENSMUST00000058060.5 ENSMUST00000058060.6 ENSMUST00000058060.7 ENSMUST00000058060.8 ENSMUST00000058060.9 Fam44b NM_001024919 Q5SQY2 uc007iim.1 uc007iim.2 uc007iim.3 Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Component of the SET1B complex composed of the catalytic subunit SETD1B, WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1, DPY30 homotrimer and BOD1. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Chromosome, centromere, kinetochore Note=Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase. Belongs to the BOD1 family. chromosome, centromeric region kinetochore condensed chromosome kinetochore spindle pole condensed chromosome outer kinetochore protein phosphatase inhibitor activity chromosome cytoplasm centrosome microtubule organizing center cytoskeleton spindle microtubule cell cycle mitotic metaphase plate congression negative regulation of phosphoprotein phosphatase activity cell division protein phosphatase 2A binding protein localization to chromosome, centromeric region mitotic sister chromatid cohesion, centromeric mitotic sister chromatid biorientation uc007iim.1 uc007iim.2 uc007iim.3 
ENSMUST00000058077.4 Tmem212 ENSMUST00000058077.4 transmembrane protein 212 (from RefSeq NM_001164437.1) ENSMUST00000058077.1 ENSMUST00000058077.2 ENSMUST00000058077.3 NM_001164437 Q0VE21 Q8C6V3 TM212_MOUSE uc008ots.1 uc008ots.2 uc008ots.3 uc008ots.4 Membrane ; Multi-pass membrane protein Sequence=BAC35275.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008ots.1 uc008ots.2 uc008ots.3 uc008ots.4 
ENSMUST00000058086.6 Defb36 ENSMUST00000058086.6 defensin beta 36 (from RefSeq NM_001037247.4) A3KGR4 DFB36_MOUSE ENSMUST00000058086.1 ENSMUST00000058086.2 ENSMUST00000058086.3 ENSMUST00000058086.4 ENSMUST00000058086.5 NM_001037247 Q3V491 Q8K3U4 uc008nfu.1 uc008nfu.2 uc008nfu.3 Has antibacterial activity. Secreted Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium innate immune response uc008nfu.1 uc008nfu.2 uc008nfu.3 
ENSMUST00000058092.8 Mrgprg ENSMUST00000058092.8 MAS-related GPR, member G (from RefSeq NM_203492.2) ENSMUST00000058092.1 ENSMUST00000058092.2 ENSMUST00000058092.3 ENSMUST00000058092.4 ENSMUST00000058092.5 ENSMUST00000058092.6 ENSMUST00000058092.7 Ebrt2 Gm1098 MRGRG_MOUSE Mrgg NM_203492 Q498A2 Q711N2 Q91ZB5 uc009kpy.1 uc009kpy.2 Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Mas subfamily. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009kpy.1 uc009kpy.2 
ENSMUST00000058099.9 F2rl3 ENSMUST00000058099.9 F2R like thrombin or trypsin receptor 3 (from RefSeq NM_007975.4) ENSMUST00000058099.1 ENSMUST00000058099.2 ENSMUST00000058099.3 ENSMUST00000058099.4 ENSMUST00000058099.5 ENSMUST00000058099.6 ENSMUST00000058099.7 ENSMUST00000058099.8 NM_007975 O88634 PAR4_MOUSE Par4 Q8BZ77 uc009mgr.1 uc009mgr.2 uc009mgr.3 This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Mice lacking a functional copy of this gene exhibit impaired platelet activation and prolonged bleeding times. [provided by RefSeq, Sep 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036427.1, AK156729.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. Cell membrane; Multi-pass membrane protein. Highly expressed in the spleen. Slight expression in the heart, lung, skeletal muscle and kidney. No detectable expression in brain, liver or testis. Also detected in platelets. A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway blood coagulation hemostasis thrombin-activated receptor activity membrane integral component of membrane positive regulation of Rho protein signal transduction positive regulation of release of sequestered calcium ion into cytosol positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway thrombin-activated receptor signaling pathway uc009mgr.1 uc009mgr.2 uc009mgr.3 
ENSMUST00000058104.8 Zfp719 ENSMUST00000058104.8 zinc finger protein 719, transcript variant 1 (from RefSeq NM_172482.1) ENSMUST00000058104.1 ENSMUST00000058104.2 ENSMUST00000058104.3 ENSMUST00000058104.4 ENSMUST00000058104.5 ENSMUST00000058104.6 ENSMUST00000058104.7 NM_172482 Q8BIV1 Q8BIV1_MOUSE Zfp719 uc009gnd.1 uc009gnd.2 uc009gnd.3 uc009gnd.4 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009gnd.1 uc009gnd.2 uc009gnd.3 uc009gnd.4 
ENSMUST00000058109.9 Mrps7 ENSMUST00000058109.9 mitchondrial ribosomal protein S7 (from RefSeq NM_025305.3) ENSMUST00000058109.1 ENSMUST00000058109.2 ENSMUST00000058109.3 ENSMUST00000058109.4 ENSMUST00000058109.5 ENSMUST00000058109.6 ENSMUST00000058109.7 ENSMUST00000058109.8 NM_025305 Q3TSI9 Q80X85 Q9CV71 RT07_MOUSE uc007mia.1 uc007mia.2 uc007mia.3 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uS7 family. ribosomal small subunit assembly mRNA binding structural constituent of ribosome mitochondrion mitochondrial small ribosomal subunit ribosome translation rRNA binding mitochondrial translation uc007mia.1 uc007mia.2 uc007mia.3 
ENSMUST00000058119.9 Arxes2 ENSMUST00000058119.9 adipocyte-related X-chromosome expressed sequence 2 (from RefSeq NM_029823.2) ARXS2_MOUSE Arxes2 B1AUR7 C0HK80 ENSMUST00000058119.1 ENSMUST00000058119.2 ENSMUST00000058119.3 ENSMUST00000058119.4 ENSMUST00000058119.5 ENSMUST00000058119.6 ENSMUST00000058119.7 ENSMUST00000058119.8 NM_029823 Q8BK31 Q9D365 Q9D6F2 uc009uhz.1 uc009uhz.2 uc009uhz.3 uc009uhz.4 Plays a role in adipogenesis. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Strongly expressed in epididymal white and brown adipose tissue with low levels in heart. Strongly up-regulated during adipogenesis. By the PPARG agonist rosiglitazone. Arxes1 and Arxes2 appear to have arisen by retrotransposition of the signal peptidase Spcs3 followed by a segmental duplication event. Belongs to the SPCS3 family. endoplasmic reticulum signal peptidase complex endoplasmic reticulum membrane signal peptide processing peptidase activity membrane integral component of membrane protein targeting to ER fat cell differentiation uc009uhz.1 uc009uhz.2 uc009uhz.3 uc009uhz.4 
ENSMUST00000058125.9 Bex1 ENSMUST00000058125.9 brain expressed X-linked 1 (from RefSeq NM_009052.2) A3KGA2 BEX1_MOUSE ENSMUST00000058125.1 ENSMUST00000058125.2 ENSMUST00000058125.3 ENSMUST00000058125.4 ENSMUST00000058125.5 ENSMUST00000058125.6 ENSMUST00000058125.7 ENSMUST00000058125.8 NM_009052 O88858 Q9R1J2 Q9R224 Rex3 uc009uig.1 uc009uig.2 Signaling adapter molecule involved in p75NTR/NGFR signaling (By similarity). Plays a role in cell cycle progression and neuronal differentiation (By similarity). Inhibits neuronal differentiation in response to nerve growth factor (NGF) (By similarity). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (PubMed:34562363). Interacts with neurotrophin receptor p75NTR/NGFR (By similarity). Interacts with OMP (PubMed:12054873, PubMed:12911636, PubMed:15198671). Nucleus Cytoplasm Note=Shuttles between the cytoplasm and the nucleus. Predominantly nuclear. Primarily localized to neuronal cells within several regions of the brain, including the olfactory epithelium, bulb, peri/paraventricular nuclei, suprachiasmatic nucleus, arcuate nucleus, median eminence, lateral hypothalamic area, thalamus, hippocampus and cerebellum (at protein level). Expressed in brain, mid term embryos and to a lesser extent in ovary. In testis, it is expressed in the pachytene spermatocytes and spermatids but not in spermatogonia. Down-regulated following RA treatment. Up-regulated in parthenogenetic embryos. The histidine cluster (His cluster) and Cys-125 mediate zinc- binding. Phosphorylated. Phosphorylation of Ser-105 protects it from the proteasome. Ubiquitinated. Degraded by the proteasome. Belongs to the BEX family. Sequence=AAC61929.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; positive regulation of neuroblast proliferation protein binding nucleus cytoplasm multicellular organism development nervous system development cell differentiation axon regeneration negative regulation of neuron differentiation neurotrophin TRK receptor signaling pathway axon development uc009uig.1 uc009uig.2 
ENSMUST00000058126.15 Nr1h4 ENSMUST00000058126.15 nuclear receptor subfamily 1, group H, member 4, transcript variant 3 (from RefSeq NM_009108.2) Bar D3YTT2 E9QJW2 ENSMUST00000058126.1 ENSMUST00000058126.10 ENSMUST00000058126.11 ENSMUST00000058126.12 ENSMUST00000058126.13 ENSMUST00000058126.14 ENSMUST00000058126.2 ENSMUST00000058126.3 ENSMUST00000058126.4 ENSMUST00000058126.5 ENSMUST00000058126.6 ENSMUST00000058126.7 ENSMUST00000058126.8 ENSMUST00000058126.9 Fxr NM_009108 NR1H4_MOUSE Q60641 Q60642 Q60643 Rip14 uc007gsf.1 uc007gsf.2 uc007gsf.3 uc007gsf.4 Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved in innate immune response (PubMed:11030617, PubMed:21383957, PubMed:22820415). The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity (PubMed:20091679, PubMed:20483916). In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs). Activates transcription of the repressor MAFG (involved in regulation of BA synthesis) (PubMed:21383957, PubMed:25651182, PubMed:25545350). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) (PubMed:21383957). In ileal enterocytes activates FABP6/IBABP (involved in cytosolic transport), SLC51A/OSTA and SLC51B/OSTB (involved in secretion of conjugated BAs to the portal blood), and repressor NR0B2/SHP thereby indirectly inhibiting SLC10A2/ASBT (involved in BA uptake) (By similarity). In the intestine activates FGF15 expression and secretion leading to hepatic CYP7A1 repression; the function also involves the coordinated induction of hepatic KLB/beta-klotho expression (PubMed:16213224, PubMed:26505219). Transcriptional activation of FABP6/IBAP and SCD1 but not of ABCB11 is isoform-specific (PubMed:12393883). Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA (By similarity). Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 isoform SREBP-1C (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly) (PubMed:12421815, PubMed:15146238). Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance) (PubMed:11579204). Transrepresses APOA1 probably involving a monomeric competition with NR2A1 for binding to a DR1 element (PubMed:21804189). Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase) (PubMed:12891557, PubMed:15146238). Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes. Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3). Modulates glucose-stimulated insulin secretion and is involved in insulin resistance (PubMed:15564327, PubMed:16446356, PubMed:16557297, PubMed:16410358, PubMed:20447400). Involved in intestinal innate immunity. Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier (PubMed:16473946, PubMed:21242261). Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells (PubMed:19864602). Mediates transrepression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2 (By similarity). Involved in the TLR9-mediated protective mechanism in intestinal inflammation (PubMed:23372731). Plays a anti-inflammatory role in liver inflammation; proposed to inhibit pro-inflammatory (but not antiapoptotic) NF-kappa-B signaling (PubMed:18972444). [Isoform 2]: Activates transcription of IBAP and SDC1. [Isoform 4]: Activates transcription of IBAP and SDC1. Heterodimer with RXRA; the heterodimerization enhances the binding affinity for LXXLL motifs from coactivators (By similarity). Binds DNA predominantly as a heterodimer with RXRA (PubMed:7760852). After activation by agonist binding interacts with coactivators. Interacts with PPARGC1A, SMARCA4 and EP300 (PubMed:14729567, PubMed:18842595, PubMed:19805516). Interacts with NCOA1, NCOA2, CARM1, SETD7, PRMT1, GPS2, SMARCA4 and MED1. Interacts with XRCC5 and XRCC6; decreasing NR1H4/FXR transactivation activity towards ABCB11/BSEP. Interacts with PAGR1 and NCOA6; indicative for an association with an MLL2/MLL3 complex (ASCOM) (By similarity). Interacts with NR5A2 (PubMed:20483916). Q60641-1; O70343-1: Ppargc1a; NbExp=3; IntAct=EBI-11659377, EBI-11359934; Q60641-2; O70343-1: Ppargc1a; NbExp=2; IntAct=EBI-11659386, EBI-11359934; Nucleus Event=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=1; Synonyms=FXRbeta1, FXRalpha3, FXRalpha2(+); IsoId=Q60641-1; Sequence=Displayed; Name=2; Synonyms=FXRbeta2, FXFRalpha4, FXRalpha2(-); IsoId=Q60641-2; Sequence=VSP_003666; Name=3; Synonyms=FXRalpha1, FXRalpha1(+); IsoId=Q60641-3; Sequence=VSP_058157; Name=4; Synonyms=FXRalpha2, FXRalpha1(-); IsoId=Q60641-4; Sequence=VSP_058157, VSP_003666; Expressed in liver and kidney. Expressed in pancreatic beta cells and macrophages. Expressed in the villus epithelium in adult ileum, with highest expression in the intervillus regions. Expression in colon is reduced by inflammation. Acetylated by EP300 (PubMed:18842595). Lys-228 as is the major acetylation site for EP300; the dynamicly regulated acetylation inhibits heterodimerization with RXRA and transactivation activity. Deacetylated by SIRT1 (By similarity). Elevated acetylation levels are found in metabolic disease states (mouse models of obesity and type II diabetes) (PubMed:19883617). Methylation may increase transactivation of target genes. Phosphorylation by PKC/PRKCA increases transactivation activity by promoting association with PPARGC1A. Sumoylated upon ligand binding. Note=Activation protects mice against cholestasis, development of chronical intestinal inflammation and fibrosis. May suppress intestinal tumorigenesis. Elevated serum bile acid, cholesterol, and triglycerides, increased hepatic cholesterol and triglycerides, and a proatherogenic serum lipoprotein profile. Reduced bile acid pools and reduced fecal bile acid excretion. Mouse Nr1h4/FXR is less responsive to CDCA and more responsive to cholic acid (CA) than human FXR. [Isoform 1]: Produced by alternative promoter usage. [Isoform 2]: Produced by alternative splicing of isoform 1. [Isoform 3]: Produced by alternative promoter usage. [Isoform 4]: Produced by alternative splicing of isoform 3. Belongs to the nuclear hormone receptor family. NR1 subfamily. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding nitrogen catabolite activation of transcription from RNA polymerase II promoter transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cellular glucose homeostasis immune system process DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus nuclear euchromatin regulation of carbohydrate metabolic process regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter lipid metabolic process inflammatory response cell-cell junction assembly Notch signaling pathway multicellular organism development transcription factor binding bile acid metabolic process zinc ion binding negative regulation of tumor necrosis factor-mediated signaling pathway regulation of low-density lipoprotein particle clearance cell differentiation ligand-dependent nuclear receptor transcription coactivator activity intracellular receptor signaling pathway bile acid binding negative regulation of NF-kappaB transcription factor activity negative regulation of interferon-gamma production negative regulation of interleukin-1 production negative regulation of interleukin-2 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production toll-like receptor 4 signaling pathway toll-like receptor 9 signaling pathway regulation of urea metabolic process histone H3-R17 methylation cellular triglyceride homeostasis positive regulation of insulin secretion involved in cellular response to glucose stimulus signaling receptor activity bile acid receptor activity bile acid signaling pathway intracellular bile acid receptor signaling pathway peptide binding glucose homeostasis cholesterol homeostasis defense response to bacterium negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling steroid hormone mediated signaling pathway sequence-specific DNA binding innate immune response positive regulation of transcription from RNA polymerase II promoter positive regulation of insulin receptor signaling pathway metal ion binding retinoid X receptor binding protein heterodimerization activity negative regulation of inflammatory response lipid homeostasis fatty acid homeostasis regulation of insulin secretion involved in cellular response to glucose stimulus triglyceride homeostasis negative regulation of bile acid biosynthetic process cellular response to lipopolysaccharide cellular response to fatty acid cellular response to organonitrogen compound negative regulation of monocyte chemotactic protein-1 production interleukin-17 secretion RNA polymerase II transcription factor complex chenodeoxycholic acid binding negative regulation of interferon-gamma secretion positive regulation of adipose tissue development negative regulation of tumor necrosis factor secretion positive regulation of phosphatidic acid biosynthetic process positive regulation of glutamate metabolic process positive regulation of ammonia assimilation cycle double-stranded DNA binding uc007gsf.1 uc007gsf.2 uc007gsf.3 uc007gsf.4 
ENSMUST00000058135.6 Gm527 ENSMUST00000058135.6 predicted gene 527 (from RefSeq NM_001025605.1) CN028_MOUSE ENSMUST00000058135.1 ENSMUST00000058135.2 ENSMUST00000058135.3 ENSMUST00000058135.4 ENSMUST00000058135.5 NM_001025605 Q4KL13 uc007nqo.1 uc007nqo.2 uc007nqo.3 molecular_function cellular_component biological_process uc007nqo.1 uc007nqo.2 uc007nqo.3 
ENSMUST00000058136.9 Ticam1 ENSMUST00000058136.9 TIR domain containing adaptor molecule 1 (from RefSeq NM_174989.5) ENSMUST00000058136.1 ENSMUST00000058136.2 ENSMUST00000058136.3 ENSMUST00000058136.4 ENSMUST00000058136.5 ENSMUST00000058136.6 ENSMUST00000058136.7 ENSMUST00000058136.8 NM_174989 Q3UDB7 Q3UP66 Q6P6J2 Q80UF7 Q8CIB7 Q8JZV0 TCAM1_MOUSE Trif uc008dbm.1 uc008dbm.2 uc008dbm.3 uc008dbm.4 Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12855817, PubMed:16002681, PubMed:21703541). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12855817, PubMed:16002681, PubMed:21703541). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12855817, PubMed:16002681, PubMed:21703541). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (By similarity). Component of a multi-helicase- TICAM1 complex that acts as a cytoplasmic sensor of viral double- stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (PubMed:21703541). Homodimer (By similarity). Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this complex exists in resting cells with or without poly(I:C) RNA ligand stimulation (PubMed:21703541). Interacts (via TIR domain) with DDX21 (via C-terminus) (PubMed:21703541). Interacts (via TIR domain) with DHX36 (via C-terminus) (PubMed:21703541). Interacts with AZI2 and IRF7 (By similarity). Interacts (when phosphorylated) with IRF3; following activation and phosphorylation on the pLxIS motif by TBK1, recruits IRF3 (By similarity). Interacts with TICAM2 in TLR4 recruitment (By similarity). Interaction with PIAS4 inhibits the TICAM1-induced NF- kappa-B, IRF and IFNB1 activation (By similarity). Interacts with IKBKB and IKBKE (By similarity). Interaction with SARM1 blocks TICAM1- dependent transcription factor activation (By similarity). Interacts with TRAF3. Interacts with TRAFD1. Interacts with UBQLN1 (via UBA domain). Interacts with TBK1, TRAF6 and RIPK1 and these interactions are enhanced in the presence of WDFY1 (By similarity). Interacts (via the TIR domain) with TLR3 in response to poly(I:C) and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436). Interacts with TLR4 in response to poly(I:C) in a WDFY1-dependent manner (PubMed:25736436). Interacts with WDFY1 in response to poly(I:C) (PubMed:25736436). Interacts with TRIM56 (By similarity). Interacts (via the TIR domain) with TLR5 (By similarity). Interacts with TRIM8 (By similarity). Q80UF7; P35991: Btk; NbExp=2; IntAct=EBI-3649271, EBI-625119; Q80UF7; Q3TTA7: Cblb; NbExp=2; IntAct=EBI-3649271, EBI-3649276; Q80UF7; Q9WUN2: Tbk1; NbExp=2; IntAct=EBI-3649271, EBI-764193; Q80UF7; Q60803: Traf3; NbExp=2; IntAct=EBI-3649271, EBI-520135; Cytoplasm, cytosol Cytoplasmic vesicle, autophagosome Mitochondrion Note=Colocalizes with UBQLN1 in the autophagosome. Colocalizes in the cytosol with DDX1, DDX21 and DHX36 (PubMed:21703541). Colocalizes in the mitochondria with DDX1 and poly(I:C) RNA ligand (PubMed:21703541). The multi-helicase- TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA ligand stimulation (PubMed:21703541). The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of TICAM1 recruits IRF3. IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and other cytokines. The N-terminal region is essential for activation of the IFNB promoter activity. The N-terminal domain (TRIF-NTD) is globular and consists of two alpha-helical subdomains connected by a 14-residue linker. It shares structural similarity with IFIT family members N-terminal regions. Phosphorylated by TBK1. Following activation, phosphorylated by TBK1 at Ser-209 in the pLxIS motif. The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines. Polyubiquitinated at Lys-228 by TRIM38 with 'Lys-48'-linked chains, leading to proteasomal degradation (PubMed:26392463). Polyubiquitinated with 'Lys-6'- and 'Lys-33'-linked chains in a TRIM8- dependent manner; ubiquitination disrupts the interaction with TBK1 and subsequent interferon production (By similarity). Mice are viable but exhibit abnormalities of the innate immune system. Sequence=AAH33406.1; Type=Miscellaneous discrepancy; Evidence=; Sequence=AAH37048.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH62191.1; Type=Frameshift; Evidence=; macrophage activation involved in immune response immune system process positive regulation of myeloid dendritic cell cytokine production MyD88-independent toll-like receptor signaling pathway protein binding cytoplasm mitochondrion autophagosome cytosol apoptotic process inflammatory response positive regulation of autophagy positive regulation of gene expression protein kinase binding positive regulation of B cell proliferation positive regulation of protein ubiquitination cytoplasmic vesicle lipopolysaccharide-mediated signaling pathway positive regulation of protein binding positive regulation of type I interferon production response to lipopolysaccharide positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell activation TRIF-dependent toll-like receptor signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly response to exogenous dsRNA positive regulation of chemokine biosynthetic process innate immune response positive regulation of interferon-beta biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity defense response to virus cellular response to lipopolysaccharide apoptotic signaling pathway ripoptosome positive regulation of cytokine production involved in inflammatory response uc008dbm.1 uc008dbm.2 uc008dbm.3 uc008dbm.4 
ENSMUST00000058137.9 Rabl6 ENSMUST00000058137.9 RAB, member RAS oncogene family-like 6 (from RefSeq NM_001024616.2) A2AJB0 ENSMUST00000058137.1 ENSMUST00000058137.2 ENSMUST00000058137.3 ENSMUST00000058137.4 ENSMUST00000058137.5 ENSMUST00000058137.6 ENSMUST00000058137.7 ENSMUST00000058137.8 NM_001024616 Parf Q3TAT5 Q3TRU4 Q5U3K5 Q6PDP8 Q8BFS4 Q8CGJ9 RABL6_MOUSE uc008isr.1 uc008isr.2 uc008isr.3 May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A (By similarity). Nucleus Cytoplasm Note=Predominantly cytoplasmic. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTP binding nucleus cytoplasm centrosome cytosol uc008isr.1 uc008isr.2 uc008isr.3 
ENSMUST00000058142.4 Sprr3 ENSMUST00000058142.4 small proline-rich protein 3, transcript variant 1 (from RefSeq NM_011478.2) ENSMUST00000058142.1 ENSMUST00000058142.2 ENSMUST00000058142.3 NM_011478 O09116 Q059J8 SPRR3_MOUSE uc029uni.1 uc029uni.2 Cross-linked envelope protein of keratinocytes. Cytoplasm. Belongs to the cornifin (SPRR) family. protein binding cytoplasm Golgi apparatus keratinization perinuclear region of cytoplasm uc029uni.1 uc029uni.2 
ENSMUST00000058150.8 Loricrin ENSMUST00000058150.8 loricrin cornified envelope precursor protein (from RefSeq NM_008508.3) ENSMUST00000058150.1 ENSMUST00000058150.2 ENSMUST00000058150.3 ENSMUST00000058150.4 ENSMUST00000058150.5 ENSMUST00000058150.6 ENSMUST00000058150.7 LORI_MOUSE Lor NM_008508 P18165 Q8R0I9 uc008qdk.1 uc008qdk.2 Major keratinocyte cell envelope protein. Expressed in the epidermis of the ear (at protein level). Expressed in the spinous and granular layers of the tongue at P20. Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins. Contains inter- or intramolecular disulfide-bonds. Transgenic mice expressing a C-terminal truncated form of loricrin exhibited, at birth, erythrokeratoderma with an epidermal barrier dysfunction. 4 days after birth, high-expressing transgenic animals showed a generalized scaling of the skin, as well as a constricting band encircling the tail and, by day 7, a thickening of the footpads. Transgenic mice also showed retention of nuclei in the stratum corneum. The mutant loricrin protein is found in the nucleus and cytoplasm of epidermal keratinocytes, but is not detect in the cornified cell envelope. The C-terminal domain of the mutant loricrin contains a nuclear localization signal. cornified envelope structural constituent of cytoskeleton cytoplasm cytoskeleton organization cytoplasmic side of plasma membrane structural constituent of epidermis keratinization uc008qdk.1 uc008qdk.2 
ENSMUST00000058154.15 Tmtc3 ENSMUST00000058154.15 transmembrane and tetratricopeptide repeat containing 3, transcript variant 1 (from RefSeq NM_001110013.1) ENSMUST00000058154.1 ENSMUST00000058154.10 ENSMUST00000058154.11 ENSMUST00000058154.12 ENSMUST00000058154.13 ENSMUST00000058154.14 ENSMUST00000058154.2 ENSMUST00000058154.3 ENSMUST00000058154.4 ENSMUST00000058154.5 ENSMUST00000058154.6 ENSMUST00000058154.7 ENSMUST00000058154.8 ENSMUST00000058154.9 G5E8C4 G5E8C4_MOUSE NM_001110013 Tmtc3 uc007gxt.1 uc007gxt.2 uc007gxt.3 uc007gxt.4 Protein modification; protein glycosylation. Endoplasmic reticulum Membrane ; Multi-pass membrane protein Belongs to the TMTC family. mannosyltransferase activity endoplasmic reticulum membrane integral component of membrane response to endoplasmic reticulum stress protein O-linked mannosylation positive regulation of proteasomal protein catabolic process uc007gxt.1 uc007gxt.2 uc007gxt.3 uc007gxt.4 
ENSMUST00000058159.6 Cnrip1 ENSMUST00000058159.6 cannabinoid receptor interacting protein 1 (from RefSeq NM_029861.3) CNRP1_MOUSE ENSMUST00000058159.1 ENSMUST00000058159.2 ENSMUST00000058159.3 ENSMUST00000058159.4 ENSMUST00000058159.5 NM_029861 Q3TAC7 Q3UFR2 Q5M8N0 uc007iby.1 uc007iby.2 uc007iby.3 Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2 (By similarity). Highly expressed in brain. Also detected in heart, lung, intestine, kidney, testis, spleen, liver and muscle (at protein level). Belongs to the CNRIP family. cytoplasm plasma membrane protein C-terminus binding regulation of receptor activity type 1 cannabinoid receptor binding myelin sheath negative regulation of receptor activity uc007iby.1 uc007iby.2 uc007iby.3 
ENSMUST00000058162.14 Mafg ENSMUST00000058162.14 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) (from RefSeq NM_010756.3) ENSMUST00000058162.1 ENSMUST00000058162.10 ENSMUST00000058162.11 ENSMUST00000058162.12 ENSMUST00000058162.13 ENSMUST00000058162.2 ENSMUST00000058162.3 ENSMUST00000058162.4 ENSMUST00000058162.5 ENSMUST00000058162.6 ENSMUST00000058162.7 ENSMUST00000058162.8 ENSMUST00000058162.9 MAFG_MOUSE NM_010756 O54790 uc007mts.1 uc007mts.2 uc007mts.3 uc007mts.4 Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:16738329, PubMed:9679061). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:16738329, PubMed:9679061). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin gene expression when associated with NFE2L2 (By similarity). May be involved in signal transduction of extracellular H(+) (By similarity). Homodimer or heterodimer (By similarity). Homodimerization leads to transcriptional repression (By similarity). Forms high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3 (PubMed:31398338). Interacts with CREBBP; the interaction leads to acetylation of the basic region of MAFG and stimulation of NFE2 transcriptional activity through increased DNA binding (By similarity). Nucleus Expressed throughout the embryo up until 8.5 dpc with strong expression in the neural tube. Expression continues throughout the embryo with some intense expression also in the epithelium of the intestine, skeletal muscle, lens, retina, cranial nerve, and dorsal root ganglion cells. After birth, strong expression in the epidermis, hair follicles, epithelium of the digestive and respiratory tracts, and kidney tubules. Sumoylation at Lys-14 is required for active transcriptional repression. Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2. Mice, although viable and fertile, exhibit abnormal megakaryocyte proliferation as well as age-dependent behavioral defects. Megakaryocytes display both anti-glycoprotein IIb immunoreactivity and anti-acetylcholinesterase activity. Belongs to the bZIP family. Maf subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated positive regulation of gene expression adult behavior regulation of cellular pH regulation of cell proliferation sequence-specific DNA binding regulation of epidermal cell differentiation positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity uc007mts.1 uc007mts.2 uc007mts.3 uc007mts.4 
ENSMUST00000058167.3 Tmem81 ENSMUST00000058167.3 transmembrane protein 81 (from RefSeq NM_029025.3) ENSMUST00000058167.1 ENSMUST00000058167.2 NM_029025 Q4VBF9 Q9D5K1 TMM81_MOUSE uc007coz.1 uc007coz.2 uc007coz.3 Membrane ; Single-pass type I membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007coz.1 uc007coz.2 uc007coz.3 
ENSMUST00000058178.6 Tacstd2 ENSMUST00000058178.6 tumor-associated calcium signal transducer 2 (from RefSeq NM_020047.3) ENSMUST00000058178.1 ENSMUST00000058178.2 ENSMUST00000058178.3 ENSMUST00000058178.4 ENSMUST00000058178.5 NM_020047 O55130 Q8BGV3 TACD2_MOUSE Trop2 uc009cfq.1 uc009cfq.2 uc009cfq.3 May function as a growth factor receptor. Membrane ; Single-pass type I membrane protein Expressed in kidney, lung, ovary and testis. High levels of expression in immortalized keratinocytes. Belongs to the EPCAM family. extracellular space nucleus plasma membrane basal plasma membrane negative regulation of epithelial cell migration membrane integral component of membrane lateral plasma membrane regulation of epithelial cell proliferation negative regulation of stress fiber assembly ureteric bud morphogenesis negative regulation of branching involved in ureteric bud morphogenesis negative regulation of substrate adhesion-dependent cell spreading negative regulation of ruffle assembly negative regulation of cell motility positive regulation of stem cell differentiation uc009cfq.1 uc009cfq.2 uc009cfq.3 
ENSMUST00000058183.9 Ndufaf6 ENSMUST00000058183.9 NADH:ubiquinone oxidoreductase complex assembly factor 6 (from RefSeq NM_001085493.2) A2AIL4 ENSMUST00000058183.1 ENSMUST00000058183.2 ENSMUST00000058183.3 ENSMUST00000058183.4 ENSMUST00000058183.5 ENSMUST00000058183.6 ENSMUST00000058183.7 ENSMUST00000058183.8 NDUF6_MOUSE NM_001085493 uc008ryx.1 uc008ryx.2 uc008ryx.3 uc008ryx.4 uc008ryx.5 uc008ryx.6 Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of complex I subunit MT-ND1. Mitochondrion inner membrane Note=Peripherally localized on the matrix face of the mitochondrial inner membrane. Belongs to the NDUFAF6 family. nucleus cytoplasm mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain complex I assembly uc008ryx.1 uc008ryx.2 uc008ryx.3 uc008ryx.4 uc008ryx.5 uc008ryx.6 
ENSMUST00000058196.13 Susd3 ENSMUST00000058196.13 sushi domain containing 3, transcript variant 1 (from RefSeq NM_025491.5) ENSMUST00000058196.1 ENSMUST00000058196.10 ENSMUST00000058196.11 ENSMUST00000058196.12 ENSMUST00000058196.2 ENSMUST00000058196.3 ENSMUST00000058196.4 ENSMUST00000058196.5 ENSMUST00000058196.6 ENSMUST00000058196.7 ENSMUST00000058196.8 ENSMUST00000058196.9 NM_025491 Q80XL5 Q9CYV1 Q9D176 Q9DA86 SUSD3_MOUSE uc007qiz.1 uc007qiz.2 uc007qiz.3 uc007qiz.4 uc007qiz.5 Cell membrane ; Single-pass membrane protein Note=Prominently localized to cell-cell borders. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D176-1; Sequence=Displayed; Name=2; IsoId=Q9D176-2; Sequence=VSP_020835; Name=3; IsoId=Q9D176-3; Sequence=VSP_020836, VSP_020837; Sequence=BAB24394.1; Type=Frameshift; Evidence=; molecular_function plasma membrane biological_process membrane integral component of membrane uc007qiz.1 uc007qiz.2 uc007qiz.3 uc007qiz.4 uc007qiz.5 
ENSMUST00000058210.13 Eps8 ENSMUST00000058210.13 epidermal growth factor receptor pathway substrate 8, transcript variant 1 (from RefSeq NM_007945.4) ENSMUST00000058210.1 ENSMUST00000058210.10 ENSMUST00000058210.11 ENSMUST00000058210.12 ENSMUST00000058210.2 ENSMUST00000058210.3 ENSMUST00000058210.4 ENSMUST00000058210.5 ENSMUST00000058210.6 ENSMUST00000058210.7 ENSMUST00000058210.8 ENSMUST00000058210.9 EPS8_MOUSE NM_007945 Q08509 Q3TM41 uc009enc.1 uc009enc.2 uc009enc.3 Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin- based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. Homodimer. Part of a complex consisting of ABI1, EPS8 and SOS1. Interacts with BAIAP2. Interacts with SHB and LANCL1. Interacts with EGFR; mediates EPS8 phosphorylation. Interacts with MYO15A and WHRN. Q08509; Q8CBW3: Abi1; NbExp=3; IntAct=EBI-375596, EBI-375511; Q08509; Q8IZP0: ABI1; Xeno; NbExp=2; IntAct=EBI-375596, EBI-375446; Q08509; Q9UQB8: BAIAP2; Xeno; NbExp=8; IntAct=EBI-375596, EBI-525456; Q08509; O43813: LANCL1; Xeno; NbExp=2; IntAct=EBI-375596, EBI-3046631; Q08509; P27361: MAPK3; Xeno; NbExp=2; IntAct=EBI-375596, EBI-73995; Cytoplasm, cell cortex. Cell projection, ruffle membrane. Cell projection, growth cone Cell projection, stereocilium napse, synaptosome Note=Localizes at the tips of the stereocilia of the inner and outer hair cells (PubMed:24741995, PubMed:23918390). Localizes to the midzone of dividing cells. Expressed in neuronal cell body and neurites, and prominently enriched in the axonal growth cone (PubMed:19564905). Expressed at the tips of cochlear hair cells stereocilia (PubMed:23918390). The effector region is required for activating the Rac-specific guanine nucleotide exchange factor (GEF) activity (PubMed:11524436). It mediates both barbed-end actin capping and actin bundling activities (PubMed:20532239). The capping activity is mediated by an amphipathic helix that binds within the hydrophobic pocket at the barbed ends of actin blocking further addition of actin monomers, while the bundling activity is mediated by a compact 4 helix bundle, which contacts 3 actin subunits along the filament (PubMed:20532239). The SH3 domain mediates interaction with SHB. Ubiquitinated by the SCF(FBXW5) E3 ubiquitin-protein ligase complex during G2 phase, leading to its transient degradation and subsequent cell shape changes required to allow mitotic progression. Reappears at the midzone of dividing cells. Phosphorylation at Ser-624 and Thr-628 by MAPK following BDNF treatment promotes removal from actin and filopodia formation. Phosphorylated by several receptor tyrosine kinases. No visible phenotype. Defects in PDGF-induced membrane ruffling due to defects in Ras to Rac signals. Dendritic cells are impaired in directional and chemotactic migration and are delayed in reaching the draining lymph node in vivo after inflammatory challenge. Mice show short stereocilia. Belongs to the EPS8 family. actin binding protein binding cytoplasm plasma membrane brush border cell cortex Rho protein signal transduction adult locomotory behavior regulation of cell shape positive regulation of signal transduction exit from mitosis postsynaptic density membrane Rac protein signal transduction NMDA selective glutamate receptor complex cell junction growth cone regulation of actin filament length actin cytoskeleton reorganization stereocilium stereocilium bundle stereocilium tip ruffle membrane regulation of Rho protein signal transduction signaling adaptor activity dendritic cell migration cell projection neuron projection synapse behavioral response to ethanol Rac GTPase binding barbed-end actin filament capping actin filament bundle assembly actin crosslink formation actin polymerization-dependent cell motility glutamatergic synapse regulation of postsynaptic specialization membrane neurotransmitter receptor levels positive regulation of ruffle assembly cellular response to leukemia inhibitory factor Rac guanyl-nucleotide exchange factor activity uc009enc.1 uc009enc.2 uc009enc.3 
ENSMUST00000058213.6 Oxgr1 ENSMUST00000058213.6 oxoglutarate (alpha-ketoglutarate) receptor 1 (from RefSeq NM_001001490.3) ENSMUST00000058213.1 ENSMUST00000058213.2 ENSMUST00000058213.3 ENSMUST00000058213.4 ENSMUST00000058213.5 Gpr99 NM_001001490 OXGR1_MOUSE Q0VEK6 Q3UQE9 Q6IYF8 uc007uzo.1 uc007uzo.2 Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway. Cell membrane; Multi-pass membrane protein. Predominantly expressed in the kidney with limited expression in the testis and the smooth muscle. Belongs to the G-protein coupled receptor 1 family. Sequence=BAE25093.1; Type=Frameshift; Evidence=; G-protein coupled adenosine receptor activity purine nucleoside binding adenosine receptor signaling pathway G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway membrane integral component of membrane AMP binding uc007uzo.1 uc007uzo.2 
ENSMUST00000058229.6 Rp1l1 ENSMUST00000058229.6 retinitis pigmentosa 1 homolog like 1 (from RefSeq NM_146246.3) ENSMUST00000058229.1 ENSMUST00000058229.2 ENSMUST00000058229.3 ENSMUST00000058229.4 ENSMUST00000058229.5 NM_146246 Q8CGM2 Q8K0I4 RP1L1_MOUSE Rp1hl1 uc007uia.1 uc007uia.2 uc007uia.3 This gene encodes a member of the doublecortin family. This protein is a retinal-specific protein. It contains two N-terminal doublecortin domains, which can assemble and stabilize axonemal microtubules, but lacks the C-terminal repetitive regions including the 16aa repeat found in human RP1L1. This protein and the RP1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. [provided by RefSeq, Sep 2010]. ##Evidence-Data-START## Transcript exon combination :: BC129887.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors. Interacts with RP1; has a synergistic effect with RP1 in photoreceptor differentiation. Cytoplasm, cytoskeleton, cilium axoneme Cell projection, cilium, photoreceptor outer segment Note=Localized to the axoneme of outer segments and connecting cilia in rod photoreceptors. Retinal-specific; expressed in photoreceptor. Detected in retina at birth but not at prenatal stages. Mice display scattered outer segment disorganization, reduced electroretinogram amplitudes, and progressive photoreceptor degeneration. In single rods defective cells photosensitivity is reduced. Rp1 and Rp1l1 double heterozygotes exhibits abnormal outer segment morphology and reduced single rod photosensitivity and dark currents, while individual heterozygotes are normal. Sequence=AAH31365.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; photoreceptor outer segment molecular_function cytoplasm cytoskeleton cilium axoneme visual perception cell projection organization photoreceptor connecting cilium axoneme assembly intracellular signal transduction photoreceptor cell development cell projection photoreceptor cell maintenance response to stimulus retina development in camera-type eye uc007uia.1 uc007uia.2 uc007uia.3 
ENSMUST00000058237.14 Ugt1a7c ENSMUST00000058237.14 UDP glucuronosyltransferase 1 family, polypeptide A7C (from RefSeq NM_201642.4) B2RUL6 ENSMUST00000058237.1 ENSMUST00000058237.10 ENSMUST00000058237.11 ENSMUST00000058237.12 ENSMUST00000058237.13 ENSMUST00000058237.2 ENSMUST00000058237.3 ENSMUST00000058237.4 ENSMUST00000058237.5 ENSMUST00000058237.6 ENSMUST00000058237.7 ENSMUST00000058237.8 ENSMUST00000058237.9 NM_201642 Q6XL45 Q6ZQM8 UD17_MOUSE Ugt1a7 uc007byc.1 uc007byc.2 uc007byc.3 UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21033; Evidence=; Reaction=17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52868, ChEBI:CHEBI:15378, ChEBI:CHEBI:17160, ChEBI:CHEBI:57529, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52869; Evidence=; Reaction=mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP; Xref=Rhea:RHEA:63704, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:62932, ChEBI:CHEBI:149486; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63705; Evidence=; Reaction=SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP; Xref=Rhea:RHEA:63696, ChEBI:CHEBI:8988, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:149482; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63697; Evidence=; Reaction=prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D- glucuronide + UDP; Xref=Rhea:RHEA:63612, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:147403, ChEBI:CHEBI:147405; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63613; Evidence=; Reaction=candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP; Xref=Rhea:RHEA:63724, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:149509, ChEBI:CHEBI:149522; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63725; Evidence=; Homodimer. Homooligomer. Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers. Endoplasmic reticulum membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=1; Comment=UGT1A7 is one of the isoforms produced at the UGT1A complex locus. The UGT1A complex locus produces different isoforms based on alternative use of promoters, first exons and terminal exons. ; Name=1; IsoId=Q6ZQM8-1; Sequence=Displayed; Widely expressed with highest levels detected in colon and kidney. Belongs to the UDP-glycosyltransferase family. endoplasmic reticulum endoplasmic reticulum membrane estrogen catabolic process glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups aromatic compound catabolic process intracellular membrane-bounded organelle coumarin catabolic process flavonoid glucuronidation xenobiotic glucuronidation uc007byc.1 uc007byc.2 uc007byc.3 
ENSMUST00000058240.14 9930012K11Rik ENSMUST00000058240.14 RIKEN cDNA 9930012K11 gene, transcript variant 1 (from RefSeq NM_001004155.2) CH058_MOUSE ENSMUST00000058240.1 ENSMUST00000058240.10 ENSMUST00000058240.11 ENSMUST00000058240.12 ENSMUST00000058240.13 ENSMUST00000058240.2 ENSMUST00000058240.3 ENSMUST00000058240.4 ENSMUST00000058240.5 ENSMUST00000058240.6 ENSMUST00000058240.7 ENSMUST00000058240.8 ENSMUST00000058240.9 NM_001004155 Q3V1T6 Q66JV7 Q8K281 uc007ung.1 uc007ung.2 uc007ung.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q66JV7-1; Sequence=Displayed; Name=2; IsoId=Q66JV7-2; Sequence=VSP_024877; Sequence=AAH32212.1; Type=Erroneous initiation; Evidence=; molecular_function biological_process uc007ung.1 uc007ung.2 uc007ung.3 
ENSMUST00000058265.8 C1galt1c1 ENSMUST00000058265.8 C1GALT1-specific chaperone 1 (from RefSeq NM_021550.3) C1GLC_MOUSE Cosmc ENSMUST00000058265.1 ENSMUST00000058265.2 ENSMUST00000058265.3 ENSMUST00000058265.4 ENSMUST00000058265.5 ENSMUST00000058265.6 ENSMUST00000058265.7 NM_021550 Q9JMG2 uc009tag.1 uc009tag.2 uc009tag.3 uc009tag.4 Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3- galactosyltransferase (C1GALT1) (By similarity). Associates with core 1 beta-3-galactosyltransferase (C1GALT1), probably not with the soluble active form. Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. Was originally assigned to be a glycosyltransferase. Name=Functional Glycomics Gateway - GTase; Note=C1GALT2 (same seq as COSMC); URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_467"; protein O-linked glycosylation membrane integral component of membrane glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity O-glycan processing, core 1 platelet activation platelet morphogenesis uc009tag.1 uc009tag.2 uc009tag.3 uc009tag.4 
ENSMUST00000058266.9 Ttll13 ENSMUST00000058266.9 tubulin tyrosine ligase-like family, member 13, transcript variant 2 (from RefSeq NM_177765.4) A4Q9F6 ENSMUST00000058266.1 ENSMUST00000058266.2 ENSMUST00000058266.3 ENSMUST00000058266.4 ENSMUST00000058266.5 ENSMUST00000058266.6 ENSMUST00000058266.7 ENSMUST00000058266.8 NM_177765 Q8C0W9 TTL13_MOUSE Ttll13 uc009hzw.1 uc009hzw.2 Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:17499049). Mediates ATP-dependent polyglutamate side- chain elongation of the polyglutamylation reaction but not the initiation step (PubMed:17499049). Preferentially modifies the alpha- tubulin tail over a beta-tail (PubMed:17499049). Reaction=(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60148, Rhea:RHEA-COMP:15519, Rhea:RHEA-COMP:15675, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143623, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60149; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Highly expressed in heart and testis (PubMed:17499049). Expressed in brain, kidney, liver, lung, muscle and trachea (PubMed:17499049). In the brain, expressed in ependymal cilia, cortex, corpus callosum and striatum (PubMed:23897886). The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding. Gln-208 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate- chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation. Belongs to the tubulin--tyrosine ligase family. Sequence=BAC26514.1; Type=Frameshift; Evidence=; nucleotide binding molecular_function ATP binding cellular_component microtubule cellular protein modification process biological_process ligase activity uc009hzw.1 uc009hzw.2 
ENSMUST00000058280.13 Prodh2 ENSMUST00000058280.13 proline dehydrogenase (oxidase) 2, transcript variant 1 (from RefSeq NM_019546.6) ENSMUST00000058280.1 ENSMUST00000058280.10 ENSMUST00000058280.11 ENSMUST00000058280.12 ENSMUST00000058280.2 ENSMUST00000058280.3 ENSMUST00000058280.4 ENSMUST00000058280.5 ENSMUST00000058280.6 ENSMUST00000058280.7 ENSMUST00000058280.8 ENSMUST00000058280.9 HYPDH_MOUSE Hypdh NM_019546 Prodh2 Q2V058 Q8VCZ9 Q9QX62 uc009geo.1 uc009geo.2 uc009geo.3 Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L- hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis. Reaction=a quinone + trans-4-hydroxy-L-proline = (3R,5S)-1-pyrroline-3- hydroxy-5-carboxylate + a quinol + H(+); Xref=Rhea:RHEA:52512, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:58375, ChEBI:CHEBI:62612, ChEBI:CHEBI:132124; EC=1.5.5.3; Evidence=; Reaction=a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+); Xref=Rhea:RHEA:23784, ChEBI:CHEBI:15378, ChEBI:CHEBI:17388, ChEBI:CHEBI:24646, ChEBI:CHEBI:60039, ChEBI:CHEBI:132124; EC=1.5.5.2; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Expressed in liver at 14 dpc. Expression level increases at P5 and decreases after P21. In liver, by TCF1 and HNF4A. Belongs to the proline oxidase family. Sequence=AAF21466.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAQ13907.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; proline dehydrogenase activity mitochondrion mitochondrial inner membrane proline metabolic process proline catabolic process proline catabolic process to glutamate oxidoreductase activity oxidoreductase activity, acting on the CH-NH group of donors oxidation-reduction process FAD binding uc009geo.1 uc009geo.2 uc009geo.3 
ENSMUST00000058295.6 Erbb2 ENSMUST00000058295.6 erb-b2 receptor tyrosine kinase 2 (from RefSeq NM_001003817.1) ENSMUST00000058295.1 ENSMUST00000058295.2 ENSMUST00000058295.3 ENSMUST00000058295.4 ENSMUST00000058295.5 ERBB2_MOUSE Kiaa3023 NM_001003817 Neu P70424 Q61525 Q6ZPE0 uc007lgi.1 uc007lgi.2 uc007lgi.3 Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1197. Interacts with PLXNB1. Interacts (when phosphorylated on Tyr-1249) with MEMO1. Interacts with MUC1. Interacts (when phosphorylated on Tyr-1140) with GRB7 (via SH2 domain). Interacts (when phosphorylated on Tyr-1249) with ERBIN. Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC, PTK6, RPA194 and ACTB. Interacts (preferentially with the tyrosine phosphorylated form) with CPNE3; this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner. Interacts with HSP90AA1 and HSP90AB1 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity (By similarity). Interacts with SRC (PubMed:7542762). Interacts with MYOC (PubMed:23897819). Interacts with PRKCABP (PubMed:11278603). Interacts with SORL1; this interaction regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulates ERBB2-mediated signaling (By similarity). Interacts with SH3BGRL (By similarity). P70424; P18762: Adrb2; NbExp=3; IntAct=EBI-2945468, EBI-491143; P70424; Q61526: Erbb3; NbExp=2; IntAct=EBI-2945468, EBI-931878; P70424; P42227: Stat3; NbExp=4; IntAct=EBI-2945468, EBI-602878; Cell membrane ; Single-pass type I membrane protein Cell projection, ruffle membrane ; Single-pass type I membrane protein Early endosome Cytoplasm, perinuclear region Nucleus Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in endosome-to-TGN retrograde vesicles. Internalized from the cell membrane in response to EGF stimulation. Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers. On days 1-4 of pregnancy, ERBB2 is detected primarily in epithelial cells, the day 1 uterus showing the highest accumulation. On day 5, the epithelium and the decidualizing stromal cells around the implanting blastocyst exhibit accumulation of this receptor. On days 6-8, the expression persists in the epithelium at both the implantation and interimplantation sites in addition to modest levels in the secondary decidual zone. On days 7 and 8, accumulation is also prominent in the trophoblastic giant cells. Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Ligand-binding increases phosphorylation on tyrosine residues. Signaling via SEMA4C promotes phosphorylation at Tyr-1249. Dephosphorylated by PTPN12. Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Sequence=BAC98297.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding RNA polymerase I core binding positive regulation of protein phosphorylation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity protein binding ATP binding nucleus cytoplasm endosome early endosome cytosol plasma membrane integral component of plasma membrane microvillus protein phosphorylation signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway nervous system development peripheral nervous system development heart development neuromuscular junction development protein C-terminus binding motor neuron axon guidance positive regulation of cell proliferation basal plasma membrane glial cell differentiation endosome membrane positive regulation of gene expression phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane kinase activity phosphorylation basolateral plasma membrane apical plasma membrane transferase activity peptidyl-tyrosine phosphorylation growth factor binding protein phosphatase binding neuron differentiation positive regulation of cell growth cytoplasmic vesicle ubiquitin protein ligase binding regulation of microtubule-based process negative regulation of immature T cell proliferation in thymus intracellular signal transduction wound healing myelination identical protein binding negative regulation of apoptotic process myelin sheath lateral loop receptor complex positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of GTPase activity estrous cycle membrane raft postsynaptic membrane positive regulation of translation positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of Ras protein signal transduction protein autophosphorylation protein heterodimerization activity perinuclear region of cytoplasm sympathetic nervous system development response to axon injury oligodendrocyte differentiation positive regulation of epithelial cell proliferation Hsp90 protein binding regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus positive regulation of protein targeting to membrane uc007lgi.1 uc007lgi.2 uc007lgi.3 
ENSMUST00000058300.14 Il17rc ENSMUST00000058300.14 interleukin 17 receptor C, transcript variant 1 (from RefSeq NM_178942.1) ENSMUST00000058300.1 ENSMUST00000058300.10 ENSMUST00000058300.11 ENSMUST00000058300.12 ENSMUST00000058300.13 ENSMUST00000058300.2 ENSMUST00000058300.3 ENSMUST00000058300.4 ENSMUST00000058300.5 ENSMUST00000058300.6 ENSMUST00000058300.7 ENSMUST00000058300.8 ENSMUST00000058300.9 G3X9C0 I17RC_MOUSE NM_178942 Q8K4C2 Q99J43 uc009dgl.1 uc009dgl.2 uc009dgl.3 uc009dgl.4 uc009dgl.5 Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:27923703, PubMed:19144317). Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:17911633, PubMed:20554964). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (By similarity). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (By similarity). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:28813677). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (PubMed:28813677). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma- delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (PubMed:32076265). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:20554964). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (PubMed:27923703). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317). Homodimer; disulfide-linked (By similarity). Heterodimer with IL17RA (PubMed:20554964). Heterodimerization with IL17RA is independent of the cytoplasmic tail. Associates with non-glycosylated IL17RA constitutively. Binding of IL17A and IL17F induces association with glycosylated IL17RA (PubMed:20554964). Forms complexes with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule (By similarity). IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex, whereas IL17F homodimer forms predominantly complexes with IL17RC homodimer (By similarity). IL17A-IL17F forms complexes with IL17RA-IL17RC, but with lower affinity when compared to IL17A homodimer (By similarity). IL17RC chain cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (By similarity). Interacts (through SEFIR domain and extended downstream region) with TRAF3IP2/ACT1 (phosphorylated) (PubMed:20554964). [Isoform 1]: Cell membrane ; Single-pass type I membrane protein [Isoform 2]: Cell membrane ; Single-pass type I membrane protein [Isoform 3]: Cell membrane ; Single-pass type I membrane protein [Isoform 4]: Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=IL17RC ; IsoId=Q8K4C2-3; Sequence=Displayed; Name=2; Synonyms=IL17RC-delta7 ; IsoId=Q8K4C2-4; Sequence=VSP_058139; Name=3; Synonyms=IL17RC-delta7,8 ; IsoId=Q8K4C2-1; Sequence=VSP_058140; Name=4; Synonyms=IL17RC-delta8 ; IsoId=Q8K4C2-5; Sequence=VSP_058141; Name=5; IsoId=Q8K4C2-2; Sequence=VSP_058142; Highly expressed in colonic epithelial cells (PubMed:19144317). Expressed in lung epithelial cells (PubMed:28813677). Expressed in macrophages (PubMed:19144317). Highly expressed in B-1a B cells and at a lower extent in B-1b and B-2 B cells (at protein level) (PubMed:26735852). Induced in lung epithelial cells upon bacterial and fungal infection. Up-regulated in lung epithelial cells by IL17F; this might account for a persistent activation via a positive feedback loop. receptor binding protein binding plasma membrane cell surface membrane integral component of membrane cytokine-mediated signaling pathway interleukin-17 receptor activity defense response to fungus granulocyte chemotaxis positive regulation of cytokine production involved in inflammatory response positive regulation of interleukin-6 secretion uc009dgl.1 uc009dgl.2 uc009dgl.3 uc009dgl.4 uc009dgl.5 
ENSMUST00000058351.16 Pgm1 ENSMUST00000058351.16 phosphoglucomutase 1 (from RefSeq NM_028132.3) ENSMUST00000058351.1 ENSMUST00000058351.10 ENSMUST00000058351.11 ENSMUST00000058351.12 ENSMUST00000058351.13 ENSMUST00000058351.14 ENSMUST00000058351.15 ENSMUST00000058351.2 ENSMUST00000058351.3 ENSMUST00000058351.4 ENSMUST00000058351.5 ENSMUST00000058351.6 ENSMUST00000058351.7 ENSMUST00000058351.8 ENSMUST00000058351.9 NM_028132 PGM1_MOUSE Pgm2 Q3UGE3 Q922D6 Q9D0F9 uc008tva.1 uc008tva.2 uc008tva.3 uc008tva.4 This enzyme participates in both the breakdown and synthesis of glucose. Reaction=alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate; Xref=Rhea:RHEA:23536, ChEBI:CHEBI:58225, ChEBI:CHEBI:58601; EC=5.4.2.2; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Monomer. Cytoplasm Phosphorylation at Thr-467 by PAK1 significantly enhances enzymatic activity. Belongs to the phosphohexose mutase family. There is a known reversal of the Pgm1 and Pgm2 nomenclature applied to mouse versus other vertebrates. The official name of this gene in mouse is Pgm2 but it is the ortholog of other vertebrate PGM1 genes. magnesium ion binding phosphoglucomutase activity cytoplasm cytosol carbohydrate metabolic process glycogen biosynthetic process glucose metabolic process actin cytoskeleton isomerase activity intramolecular transferase activity, phosphotransferases galactose catabolic process Z disc metal ion binding organic substance metabolic process uc008tva.1 uc008tva.2 uc008tva.3 uc008tva.4 
ENSMUST00000058358.8 Leng9 ENSMUST00000058358.8 leukocyte receptor cluster (LRC) member 9 (from RefSeq NM_175529.3) ENSMUST00000058358.1 ENSMUST00000058358.2 ENSMUST00000058358.3 ENSMUST00000058358.4 ENSMUST00000058358.5 ENSMUST00000058358.6 ENSMUST00000058358.7 LENG9_MOUSE NM_175529 Q3UYM5 Q8BTG8 Q8BTN6 uc009exd.1 uc009exd.2 uc009exd.3 molecular_function cellular_component metal ion binding uc009exd.1 uc009exd.2 uc009exd.3 
ENSMUST00000058370.14 Ccdc137 ENSMUST00000058370.14 coiled-coil domain containing 137, transcript variant 3 (from RefSeq NR_184649.1) CC137_MOUSE ENSMUST00000058370.1 ENSMUST00000058370.10 ENSMUST00000058370.11 ENSMUST00000058370.12 ENSMUST00000058370.13 ENSMUST00000058370.2 ENSMUST00000058370.3 ENSMUST00000058370.4 ENSMUST00000058370.5 ENSMUST00000058370.6 ENSMUST00000058370.7 ENSMUST00000058370.8 ENSMUST00000058370.9 NR_184649 Q3U0P6 Q8R0K4 uc007msu.1 uc007msu.2 uc007msu.3 uc007msu.4 Chromosome Sequence=BAE33806.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; fibrillar center chromosome nucleolus biological_process uc007msu.1 uc007msu.2 uc007msu.3 uc007msu.4 
ENSMUST00000058383.9 Paip2b ENSMUST00000058383.9 poly(A) binding protein interacting protein 2B (from RefSeq NM_146169.2) B9EJI7 ENSMUST00000058383.1 ENSMUST00000058383.2 ENSMUST00000058383.3 ENSMUST00000058383.4 ENSMUST00000058383.5 ENSMUST00000058383.6 ENSMUST00000058383.7 ENSMUST00000058383.8 Kiaa1155 NM_146169 PAI2B_MOUSE Q69ZQ4 Q8BL93 Q91W45 uc009cok.1 uc009cok.2 uc009cok.3 uc009cok.4 uc009cok.5 Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail. Interacts (via central acidic portion and C-terminus) with PABPC1 (via the second and third RRM domains and the C-terminus). Expressed at very high levels in pancreas, at high levels in testis and at moderately high levels in brain, heart and lung (at protein level). Ubiquitinated in vitro. Belongs to the PAIP2 family. It is uncertain whether Met-1 or Met-14 is the initiator. Sequence=BAD32392.1; Type=Erroneous initiation; Evidence=; translation repressor activity, nucleic acid binding cellular_component regulation of translation poly(A) binding negative regulation of translation negative regulation of translational initiation uc009cok.1 uc009cok.2 uc009cok.3 uc009cok.4 uc009cok.5 
ENSMUST00000058393.9 A430005L14Rik ENSMUST00000058393.9 RIKEN cDNA A430005L14 gene, transcript variant 1 (from RefSeq NM_175287.4) A2AM12 CA174_MOUSE ENSMUST00000058393.1 ENSMUST00000058393.2 ENSMUST00000058393.3 ENSMUST00000058393.4 ENSMUST00000058393.5 ENSMUST00000058393.6 ENSMUST00000058393.7 ENSMUST00000058393.8 NM_175287 Q80WR5 Q8CA21 uc008wau.1 uc008wau.2 uc008wau.3 uc008wau.4 Nucleus Belongs to the UPF0688 family. Sequence=CAM18763.1; Type=Erroneous gene model prediction; Evidence=; molecular_function nucleus biological_process uc008wau.1 uc008wau.2 uc008wau.3 uc008wau.4 
ENSMUST00000058404.5 Mycs ENSMUST00000058404.5 myc-like oncogene, s-myc protein (from RefSeq NM_010850.2) ENSMUST00000058404.1 ENSMUST00000058404.2 ENSMUST00000058404.3 ENSMUST00000058404.4 MYCS_MOUSE NM_010850 Q3V0Z1 Q9Z304 uc009sks.1 uc009sks.2 uc009sks.3 uc009sks.4 Has apoptosis-inducing activity. Efficient DNA binding requires dimerization with another bHLH protein. Nucleus RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated apoptotic process positive regulation of transcription from RNA polymerase II promoter protein dimerization activity uc009sks.1 uc009sks.2 uc009sks.3 uc009sks.4 
ENSMUST00000058407.6 Uqcr10 ENSMUST00000058407.6 ubiquinol-cytochrome c reductase, complex III subunit X, transcript variant 1 (from RefSeq NM_197979.3) ENSMUST00000058407.1 ENSMUST00000058407.2 ENSMUST00000058407.3 ENSMUST00000058407.4 ENSMUST00000058407.5 NM_197979 Q8R1I1 QCR9_MOUSE uc007hvb.1 uc007hvb.2 uc007hvb.3 Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:19026783). Interacts with STMP1 (PubMed:35101990). Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the UQCR10/QCR9 family. mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex III mitochondrial electron transport, ubiquinol to cytochrome c aerobic respiration membrane mitochondrial respiratory chain complex III assembly oxidation-reduction process respiratory chain ubiquinol-cytochrome-c reductase activity uc007hvb.1 uc007hvb.2 uc007hvb.3 
ENSMUST00000058418.8 Slc29a4 ENSMUST00000058418.8 solute carrier family 29 (nucleoside transporters), member 4, transcript variant 1 (from RefSeq NM_146257.3) ENSMUST00000058418.1 ENSMUST00000058418.2 ENSMUST00000058418.3 ENSMUST00000058418.4 ENSMUST00000058418.5 ENSMUST00000058418.6 ENSMUST00000058418.7 Ent4 NM_146257 Q8R139 S29A4_MOUSE Slc29a4 pmat uc009aiz.1 uc009aiz.2 Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:16873718, PubMed:23255610). Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations (By similarity). Functions as a Na(+)- and Cl(-)-independent bidirectional transporter (By similarity). Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure (PubMed:16873718). Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system (PubMed:23255610). Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain (PubMed:23255610). Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (PubMed:16873718). May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney (PubMed:23255610). Also transports adenine and guanidine (PubMed:16873718). Reaction=serotonin(out) = serotonin(in); Xref=Rhea:RHEA:73867, ChEBI:CHEBI:350546; Evidence=; Reaction=dopamine(out) = dopamine(in); Xref=Rhea:RHEA:73863, ChEBI:CHEBI:59905; Evidence=; Reaction=(R)-noradrenaline(out) = (R)-noradrenaline(in); Xref=Rhea:RHEA:73871, ChEBI:CHEBI:72587; Evidence=; Reaction=(R)-adrenaline(out) = (R)-adrenaline(in); Xref=Rhea:RHEA:73875, ChEBI:CHEBI:71406; Evidence=; Reaction=histamine(out) = histamine(in); Xref=Rhea:RHEA:73879, ChEBI:CHEBI:58432; Evidence=; Reaction=tyramine(in) = tyramine(out); Xref=Rhea:RHEA:74783, ChEBI:CHEBI:327995; Evidence=; Reaction=guanidine(out) = guanidine(in); Xref=Rhea:RHEA:73883, ChEBI:CHEBI:30087; Evidence=; Reaction=adenine(out) = adenine(in); Xref=Rhea:RHEA:71523, ChEBI:CHEBI:16708; Evidence=; Reaction=adenosine(in) = adenosine(out); Xref=Rhea:RHEA:75343, ChEBI:CHEBI:16335; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75344; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:75345; Evidence=; Activated at acidic pH. Kinetic parameters: KM=130 uM for adenosine (at pH 5.5) ; KM=2600 uM for adenine (at pH 5.5) ; pH dependence: Optimum pH is 5.5 for adenosine and adenine uptake (PubMed:16873718). Absence of adenosine transport at pH 7.4 (PubMed:16873718). ; Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Note=Localized to the apical blood-cerebrospinal fluid(CSF)-facing membrane of the choroid plexus epithelium. Expressed in heart (PubMed:16873718). Expressed in choroid plexus (PubMed:23255610). Glu-206 is essential for cation selectivity and may function as the charge sensor for cationic substrates. N-glycosylated. Knockout mice are viable, fertile with no overt physiological abnormalities. Knockout mice show an impaired uptake of serotonin and dopamine in choroid plexus. Other than a moderate activity for adenosine, PMAT does not interact with nucleosides, nucleobases, or nucleotides (By similarity). Mediates the uptake of clinically used drugs including neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) (PubMed:23255610). Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. nucleoside transmembrane transporter activity plasma membrane monoamine transmembrane transporter activity monoamine transport membrane integral component of membrane apical plasma membrane transmembrane transport nucleoside transmembrane transport uc009aiz.1 uc009aiz.2 
ENSMUST00000058429.6 Il27 ENSMUST00000058429.6 interleukin 27 (from RefSeq NM_145636.2) ENSMUST00000058429.1 ENSMUST00000058429.2 ENSMUST00000058429.3 ENSMUST00000058429.4 ENSMUST00000058429.5 IL27A_MOUSE Il27a NM_145636 Q8K3I6 uc009jsc.1 uc009jsc.2 uc009jsc.3 Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN- gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27- mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of pro-inflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses pro-inflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP- 10/CXCL10 and MIG/CXCL9. Heterodimer with EBI3; not disulfide-linked. This heterodimer is known as interleukin IL-27. Secreted Note=Poorly secreted without coexpression of EBI3. Expressed in macrophages and dendritic cells. By LPS and Interferon gamma in primary astrocytes and microglia. Induced by Toll-like receptor ligand in dendritic cells. Inhibited by PPAR-alpha agonist such as fenofibrate and produced by TNF-alpha in microglia. O-glycosylated. In mouse models of experimental autoimmune encephalitis (EAE) induced by Toxoplasma Gondi infection, brain levels of IL-27 are massively increased. Deficiency of IL-27 receptors in this mouse model with EAE induces development of a more severe neuroinflammation than in wild-type mice with EAE. This excessive neuroinflammation is associated with increased numbers of TH17 cells in the central nervous system (CNS). Continuous administration of IL-27 to EAE mice produces a strong suppressive effect on active EAE, with reduced CNS infiltration of TH17 cells and TH17 cells activity. Mice injected with B16F10 tumor cells develop tumors and lung metastasis. In mice injected with B16F10 tumor cells stably transfected with IL-27, tumor cells grow much more slowly and the number of pulmonary metastasis is markedly reduced. IL-27 exhibits a strong antitumor activity as well as antiangiogenic activity with massive decreased of microvessels density in lung metastasis. Similarly, mice injected with C26 colon tumor cells transfected with IL-27 acquire tumor-specific protective activity and exhibit minimal tumor growth with enhanced IFN-gamma production. This antitumor activity is abolished in TBX21-deficient mice. Neuroblastoma cells overexpressing IL-27 also demonstrate markedly delayed growth; This tumor regression appears to be dependent on CD8 cells. Belongs to the IL-6 superfamily. positive regulation of defense response to virus by host immune system process receptor binding cytokine activity protein binding extracellular region extracellular space cytosol inflammatory response signal transduction response to bacterium regulation of T cell proliferation positive regulation of interferon-gamma biosynthetic process innate immune response interleukin-27 receptor binding regulation of T-helper 1 cell differentiation uc009jsc.1 uc009jsc.2 uc009jsc.3 
ENSMUST00000058437.14 Rpl7 ENSMUST00000058437.14 ribosomal protein L7 (from RefSeq NM_011291.5) ENSMUST00000058437.1 ENSMUST00000058437.10 ENSMUST00000058437.11 ENSMUST00000058437.12 ENSMUST00000058437.13 ENSMUST00000058437.2 ENSMUST00000058437.3 ENSMUST00000058437.4 ENSMUST00000058437.5 ENSMUST00000058437.6 ENSMUST00000058437.7 ENSMUST00000058437.8 ENSMUST00000058437.9 NM_011291 Q5M9N8 Q5M9N8_MOUSE Rpl7 uc007ajl.1 uc007ajl.2 uc007ajl.3 uc007ajl.4 uc007ajl.5 uc007ajl.6 Cytoplasm Belongs to the universal ribosomal protein uL30 family. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome ribosome cytosolic large ribosomal subunit uc007ajl.1 uc007ajl.2 uc007ajl.3 uc007ajl.4 uc007ajl.5 uc007ajl.6 
ENSMUST00000058438.9 Dcaf7 ENSMUST00000058438.9 DDB1 and CUL4 associated factor 7 (from RefSeq NM_027946.3) DCAF7_MOUSE ENSMUST00000058438.1 ENSMUST00000058438.2 ENSMUST00000058438.3 ENSMUST00000058438.4 ENSMUST00000058438.5 ENSMUST00000058438.6 ENSMUST00000058438.7 ENSMUST00000058438.8 Han11 NM_027946 O15491 P61963 Q3TMV9 Q9DAE4 Wdr68 uc007lxz.1 uc007lxz.2 uc007lxz.3 Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). Protein modification; protein ubiquitination. Interacts with DYRK1A, DYRK1B and DIAPH1. Interacts with DDB1. Interacts with ZNF703 (By similarity). Cytoplasm Nucleus Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm. Highly expressed in 10.5 dpc embryo limb buds, in an overlapping pattern with PTCH1 and GLI1. Belongs to the WD repeat DCAF7 family. nucleus nucleoplasm cytoplasm cytosol multicellular organism development nuclear matrix protein ubiquitination nuclear body macromolecular complex Cul4-RING E3 ubiquitin ligase complex uc007lxz.1 uc007lxz.2 uc007lxz.3 
ENSMUST00000058440.12 Dnah10 ENSMUST00000058440.12 dynein, axonemal, heavy chain 10 (from RefSeq NM_019536.1) D3YYQ8 D3YYQ8_MOUSE Dnah10 Dnahc10 ENSMUST00000058440.1 ENSMUST00000058440.10 ENSMUST00000058440.11 ENSMUST00000058440.2 ENSMUST00000058440.3 ENSMUST00000058440.4 ENSMUST00000058440.5 ENSMUST00000058440.6 ENSMUST00000058440.7 ENSMUST00000058440.8 ENSMUST00000058440.9 NM_019536 uc008zqp.1 uc008zqp.2 uc008zqp.3 Belongs to the dynein heavy chain family. cilium movement microtubule motor activity ATP binding axoneme microtubule-based movement ATP-dependent microtubule motor activity, minus-end-directed dynein complex inner dynein arm dynein intermediate chain binding dynein light intermediate chain binding uc008zqp.1 uc008zqp.2 uc008zqp.3 
ENSMUST00000058444.10 Ppp1r37 ENSMUST00000058444.10 protein phosphatase 1, regulatory subunit 37 (from RefSeq NM_199149.3) ENSMUST00000058444.1 ENSMUST00000058444.2 ENSMUST00000058444.3 ENSMUST00000058444.4 ENSMUST00000058444.5 ENSMUST00000058444.6 ENSMUST00000058444.7 ENSMUST00000058444.8 ENSMUST00000058444.9 Lrrc68 NM_199149 PPR37_MOUSE Q8BKR5 uc009fmh.1 uc009fmh.2 uc009fmh.3 Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Interacts with PPP1CA. Belongs to the PPP1R37 family. protein phosphatase inhibitor activity cellular_component negative regulation of phosphatase activity negative regulation of phosphoprotein phosphatase activity uc009fmh.1 uc009fmh.2 uc009fmh.3 
ENSMUST00000058464.5 Serpina9 ENSMUST00000058464.5 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9, transcript variant 1 (from RefSeq NM_027997.4) ENSMUST00000058464.1 ENSMUST00000058464.2 ENSMUST00000058464.3 ENSMUST00000058464.4 NM_027997 Q9D7D2 SPA9_MOUSE uc007owo.1 uc007owo.2 uc007owo.3 Secreted Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular region extracellular space negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc007owo.1 uc007owo.2 uc007owo.3 
ENSMUST00000058470.16 Polr2a ENSMUST00000058470.16 polymerase (RNA) II (DNA directed) polypeptide A (from RefSeq NM_001291068.1) ENSMUST00000058470.1 ENSMUST00000058470.10 ENSMUST00000058470.11 ENSMUST00000058470.12 ENSMUST00000058470.13 ENSMUST00000058470.14 ENSMUST00000058470.15 ENSMUST00000058470.2 ENSMUST00000058470.3 ENSMUST00000058470.4 ENSMUST00000058470.5 ENSMUST00000058470.6 ENSMUST00000058470.7 ENSMUST00000058470.8 ENSMUST00000058470.9 NM_001291068 P08775 Q5F298 RPB1_MOUSE Rpii215 Rpo2-1 uc007jrk.1 uc007jrk.2 uc007jrk.3 uc007jrk.4 uc007jrk.5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates (By similarity). Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing (By similarity). Regulation of gene expression levels depends on the balance between methylation and acetylation levels of tha CTD-lysines (PubMed:26687004). Initiation or early elongation steps of transcription of growth-factors-induced immediate early genes are regulated by the acetylation status of the CTD (PubMed:24207025). Methylation and dimethylation have a repressive effect on target genes expression (PubMed:26687004). Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA- COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.6; Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits (By similarity). Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin (PubMed:19141475). The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active) (PubMed:22767893). Interacts (via the C-terminal domain (CTD)) with U2AF2; recruits PRPF19 and the Prp19 complex to the pre-mRNA and may couple transcription to pre-mRNA splicing. Interacts (via the C-terminal domain (CTD)) with SMN1/SMN2; recruits SMN1/SMN2 to RNA Pol II elongation complexes. Interacts via the phosphorylated C-terminal domain with WDR82 and with SETD1A and SETD1B only in the presence of WDR82. When phosphorylated at 'Ser-5', interacts with MEN1; the unphosphorylated form, or phosphorylated at 'Ser-2' does not interact. When phosphorylated at 'Ser-5', interacts with ZMYND8; the form phosphorylated at 'Ser-2' does not interact. When phosphorylated at 'Ser-2', interacts with SUPT6H (via SH2 domain). Interacts with RECQL5 and TCEA1; binding of RECQL5 prevents TCEA1 binding. The phosphorylated C-terminal domain interacts with FNBP3 and SYNCRIP. Interacts with ATF7IP. Interacts with DDX5 (By similarity). Interacts with WWP2 (PubMed:17526739). Interacts with SETX. Interacts (phosphorylated) with PIH1D1. Interacts (via the C-terminal domain (CTD)) with TDRD3. Interacts with PRMT5. Interacts with XRN2. Interacts with SAFB/SAFB1 (By similarity). Interacts with CCNL1 (Probable). Interacts with CCNL2 (By similarity). Interacts with MYO1C (PubMed:11030652). Interacts with PAF1 (By similarity). Interacts with SFRS19 (By similarity). Interacts (via C-terminus) with CMTR1 (By similarity). Interacts (via C-terminus) with CTDSP1 (By similarity). Interacts (via C-terminus) with SCAF8 (PubMed:8692929). Interacts (via the C-terminal domain (CTD)) with CCNT2. Interacts with FUS (By similarity). Interacts with MCM3AP. Interacts with kinase SRPK2; the interaction occurs during the co-transcriptional formation of inappropriate R-loops (By similarity). Interacts with SETD2 (By similarity). Interacts with UVSSA (By similarity). Interacts with ERCC6 (By similarity). Interacts with the TFIIH complex (By similarity). P08775; Q6PDM2: Srsf1; NbExp=2; IntAct=EBI-2549849, EBI-2550360; P08775; Q62093: Srsf2; NbExp=3; IntAct=EBI-2549849, EBI-2550402; Nucleus toplasm Chromosome Note=Hypophosphorylated form is mainly found in the cytoplasm, while the hyperphosphorylated and active form is nuclear (By similarity). Co-localizes with kinase SRPK2 and helicase DDX23 at chromatin loci where unscheduled R-loops form (By similarity). The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. The tandem heptapeptide repeats in the C-terminal domain (CTD) can be highly phosphorylated. The phosphorylation activates Pol II. Phosphorylation occurs mainly at residues 'Ser-2' and 'Ser-5' of the heptapeptide repeat and is mediated, at least, by CDK7 and CDK9. CDK7 phosphorylation of POLR2A associated with DNA promotes transcription initiation by triggering dissociation from DNA. Phosphorylation also takes place at 'Ser-7' of the heptapeptide repeat, which is required for efficient transcription of snRNA genes and processing of the transcripts. The phosphorylation state is believed to result from the balanced action of site-specific CTD kinases and phosphatases, and a 'CTD code' that specifies the position of Pol II within the transcription cycle has been proposed. Dephosphorylated by the protein phosphatase CTDSP1. Dephosphorylated at 'Ser-2' following UV irradiation. Among tandem heptapeptide repeats of the C-terminal domain (CTD) some do not match the Y-S-P-T-S-P-S consensus, the seventh serine residue 'Ser-7' being replaced by a lysine. 'Lys-7' in these non- consensus heptapeptide repeats can be alternatively acetylated, methylated and dimethylated. EP300 is one of the enzyme able to acetylate 'Lys-7'. Acetylation at 'Lys-7' of non-consensus heptapeptide repeats is associated with 'Ser-2' phosphorylation and active transcription. It may regulate initiation or early elongation steps of transcription specially for inducible genes. Ubiquitinated by WWP2 leading to proteasomal degradation (PubMed:17526739). Following transcription stress, the elongating form of RNA polymerase II (RNA pol IIo) is ubiquitinated by NEDD4 on Lys- 1268 at DNA damage sites without leading to degradation: ubiquitination promotes RNA pol IIo backtracking to allow access by the transcription- coupled nucleotide excision repair (TC-NER) machinery (By similarity). At stalled RNA pol II where TC-NER has failed, RBX1-mediated polybiquitination at Lys-1268 may lead to proteasome-mediated degradation in a UBAP2- and UBAP2L-dependent manner; presumably to halt global transcription and enable 'last resort' DNA repair pathways (By similarity). Methylated at Arg-1810 prior to transcription initiation when the CTD is hypophosphorylated, phosphorylation at Ser-1805 and Ser-1808 preventing this methylation. Symmetrically or asymmetrically dimethylated at Arg-1810 by PRMT5 and CARM1 respectively. Symmetric or asymmetric dimethylation modulates interactions with CTD-binding proteins like SMN1/SMN2 and TDRD3. SMN1/SMN2 interacts preferentially with the symmetrically dimethylated form while TDRD3 interacts with the asymmetric form. Through the recruitment of SMN1/SMN2, symmetric dimethylation is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. CTD dimethylation may also facilitate the expression of select RNAs. Among tandem heptapeptide repeats of the C-terminal domain (CTD) some do not match the Y-S-P-T-S-P-S consensus, the seventh serine residue 'Ser-7' being replaced by a lysine. 'Lys-7' in these non-consensus heptapeptide repeats can be alternatively acetylated, methylated, dimethylated and trimethylated. Methylation occurs in the earliest transcription stages and precedes or is concomitant to 'Ser-5' and 'Ser-7' phosphorylation. Dimethylation and trimehtylation at 'Lys-7' of non-consensus heptapeptide repeats are exclusively associated with phosphorylated CTD. The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion temporarily coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits. The ribonucleoside triphosphate is transferred by a rotation to the nucleotide addition (A) site for pairing with the template DNA. The catalytic A site involves three conserved aspartate residues of the RNA Pol II largest subunit which permanently coordinate a second magnesium ion. Belongs to the RNA polymerase beta' chain family. core promoter binding DNA binding DNA-directed 5'-3' RNA polymerase activity protein binding nucleus nucleoplasm DNA-directed RNA polymerase II, core complex nuclear euchromatin cytoplasm transcription, DNA-templated DNA-templated transcription, termination transcription from RNA polymerase II promoter protein C-terminus binding response to organic cyclic compound transferase activity nucleotidyltransferase activity ubiquitin protein ligase binding positive regulation of RNA splicing metal ion binding cellular response to oxygen levels promoter-specific chromatin binding Prp19 complex RNA polymerase II activity nucleolus uc007jrk.1 uc007jrk.2 uc007jrk.3 uc007jrk.4 uc007jrk.5 
ENSMUST00000058472.13 Svop ENSMUST00000058472.13 SV2 related protein, transcript variant 1 (from RefSeq NM_026805.1) ENSMUST00000058472.1 ENSMUST00000058472.10 ENSMUST00000058472.11 ENSMUST00000058472.12 ENSMUST00000058472.2 ENSMUST00000058472.3 ENSMUST00000058472.4 ENSMUST00000058472.5 ENSMUST00000058472.6 ENSMUST00000058472.7 ENSMUST00000058472.8 ENSMUST00000058472.9 NM_026805 Q6PB56 Q8BFT9 Q8BKY9 SVOP_MOUSE uc008yzb.1 uc008yzb.2 uc008yzb.3 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. integral component of plasma membrane synaptic vesicle membrane integral component of membrane transmembrane transporter activity cell junction synaptic vesicle membrane cytoplasmic vesicle synapse transmembrane transport uc008yzb.1 uc008yzb.2 uc008yzb.3 
ENSMUST00000058475.6 Neurog1 ENSMUST00000058475.6 neurogenin 1 (from RefSeq NM_010896.3) Ath4c ENSMUST00000058475.1 ENSMUST00000058475.2 ENSMUST00000058475.3 ENSMUST00000058475.4 ENSMUST00000058475.5 NGN1_MOUSE NM_010896 Neurod3 Ngn Ngn1 P70660 uc007qsl.1 uc007qsl.2 uc007qsl.3 uc007qsl.4 uc007qsl.5 Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. Efficient DNA binding requires dimerization with another bHLH protein. Nucleus Expression restricted to the embryonic nervous system. Highest expression in the embryo between days 10 and 12. Declines to undetectable levels by embryonic day 16. DNA binding chromatin binding protein binding nucleus regulation of transcription, DNA-templated multicellular organism development thorax and anterior abdomen determination nervous system development trigeminal nerve development vestibulocochlear nerve formation neurogenesis cell differentiation neuron differentiation peristalsis auditory behavior positive regulation of exit from mitosis genitalia morphogenesis inner ear morphogenesis protein homodimerization activity neuronal cell body perikaryon cell fate commitment regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter protein dimerization activity regulation of muscle organ development genitalia development inner ear development neuromuscular process controlling balance positive regulation of sequence-specific DNA binding transcription factor activity E-box binding mastication cochlea development cochlea morphogenesis craniofacial suture morphogenesis learned vocalization behavior negative regulation of relaxation of muscle negative regulation of saliva secretion hard palate morphogenesis sequence-specific double-stranded DNA binding uc007qsl.1 uc007qsl.2 uc007qsl.3 uc007qsl.4 uc007qsl.5 
ENSMUST00000058476.14 Otud7a ENSMUST00000058476.14 OTU domain containing 7A (from RefSeq NM_130880.1) Cezanne2 ENSMUST00000058476.1 ENSMUST00000058476.10 ENSMUST00000058476.11 ENSMUST00000058476.12 ENSMUST00000058476.13 ENSMUST00000058476.2 ENSMUST00000058476.3 ENSMUST00000058476.4 ENSMUST00000058476.5 ENSMUST00000058476.6 ENSMUST00000058476.7 ENSMUST00000058476.8 ENSMUST00000058476.9 NM_130880 OTU7A_MOUSE Otud7 Q8R554 uc009hfl.1 uc009hfl.2 uc009hfl.3 Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Cytoplasm Nucleus Belongs to the peptidase C64 family. DNA binding thiol-dependent ubiquitin-specific protease activity nucleus cytoplasm proteolysis peptidase activity cysteine-type peptidase activity zinc ion binding hydrolase activity protein K11-linked deubiquitination thiol-dependent ubiquitinyl hydrolase activity negative regulation of I-kappaB kinase/NF-kappaB signaling metal ion binding K63-linked polyubiquitin binding protein K63-linked deubiquitination protein K48-linked deubiquitination protein deubiquitination involved in ubiquitin-dependent protein catabolic process uc009hfl.1 uc009hfl.2 uc009hfl.3 
ENSMUST00000058479.7 Drc7 ENSMUST00000058479.7 dynein regulatory complex subunit 7 (from RefSeq NM_001042715.3) Ccdc135 DRC7_MOUSE ENSMUST00000058479.1 ENSMUST00000058479.2 ENSMUST00000058479.3 ENSMUST00000058479.4 ENSMUST00000058479.5 ENSMUST00000058479.6 G3X9B0 Gm770 NM_001042715 Q148T2 Q6V3W6 Srgl uc009mxs.1 uc009mxs.2 Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Essential for male fertility, sperm head morphogenesis and sperm flagellum formation (PubMed:31961863). Not required for ciliogenesis in the brain and trachea (PubMed:31961863). Component of the nexin-dynein regulatory complex (N-DRC) (By similarity). Interacts with TCTE1/DRC5 (PubMed:28630322, PubMed:31961863). Interacts with DRC3 and GAS8/DRC4 (PubMed:31961863). Cell projection, cilium, flagellum Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme Note=Associated with the outer doublet microtubules (OD). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SRG-L; IsoId=Q6V3W6-1; Sequence=Displayed; Name=2; Synonyms=SRG-S; IsoId=Q6V3W6-2; Sequence=VSP_023440, VSP_023441; [Isoform 1]: Expressed in diplotene and pachytene spermytocytes, and in round and elongating spermatids (at protein level). Strongly expressed in spleen and testis, faintly expressed in kidney, ovary and thymus. Abundantly expressed in the testis and is weakly expressed in the brain, thymus, lung and ovary (PubMed:31961863). Expressed in ciliated cells (PubMed:17971504). Male mice were infertile due to their short immotile spermatozoa (PubMed:31961863). Axoneme formation and manchette removal are impaired in spermatids (PubMed:31961863). No morphological abnormalities seen in multicilia of ependymal and tracheal epithelia and cilia motility is not impaired in ependymal cilia (PubMed:31961863). Belongs to the DRC7 family. protein binding cytoplasm cytoskeleton cilium spermatogenesis cell differentiation flagellated sperm motility motile cilium cell projection cell motility uc009mxs.1 uc009mxs.2 
ENSMUST00000058488.9 Tmed3 ENSMUST00000058488.9 transmembrane p24 trafficking protein 3 (from RefSeq NM_025360.2) ENSMUST00000058488.1 ENSMUST00000058488.2 ENSMUST00000058488.3 ENSMUST00000058488.4 ENSMUST00000058488.5 ENSMUST00000058488.6 ENSMUST00000058488.7 ENSMUST00000058488.8 NM_025360 Q78IS1 Q9DC62 Q9DCK9 TMED3_MOUSE uc009qzo.1 uc009qzo.2 uc009qzo.3 uc009qzo.4 Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network (By similarity). Monomer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Interacts (via C- terminus) with COPG1; the interaction involves dimeric TMED3; however, there are conflicting reports on the interaction. Interacts with GORASP1 and GORASP2 (By similarity). Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein Golgi apparatus, cis-Golgi network membrane ; Single-pass type I membrane protein Golgi apparatus, Golgi stack membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Cytoplasmic vesicle, COPI-coated vesicle membrane ; Single-pass type I membrane protein Note=Probably cycles between compartments of the early secretatory pathway. Belongs to the EMP24/GP25L family. Sequence=BAB22292.1; Type=Frameshift; Evidence=; molecular_function endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus intracellular protein transport ER to Golgi vesicle-mediated transport Golgi organization protein transport membrane integral component of membrane COPI vesicle coat ER to Golgi transport vesicle COPI-coated vesicle membrane cytoplasmic vesicle Golgi cisterna membrane endoplasmic reticulum-Golgi intermediate compartment membrane uc009qzo.1 uc009qzo.2 uc009qzo.3 uc009qzo.4 
ENSMUST00000058491.8 Tmem121 ENSMUST00000058491.8 transmembrane protein 121 (from RefSeq NM_153776.2) ENSMUST00000058491.1 ENSMUST00000058491.2 ENSMUST00000058491.3 ENSMUST00000058491.4 ENSMUST00000058491.5 ENSMUST00000058491.6 ENSMUST00000058491.7 Hole NM_153776 Q80XA0 Q8R3W8 Q8R4A5 TM121_MOUSE uc007pgc.1 uc007pgc.2 uc007pgc.3 uc007pgc.4 May play a role in MAPK signaling. Membrane ; Multi-pass membrane protein Note=May localize to the plasma membrane. Displays strong neural pattern at 8.5 dpc to 12.5 dpc. Not expressed in the heart. Belongs to the TMEM121 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007pgc.1 uc007pgc.2 uc007pgc.3 uc007pgc.4 
ENSMUST00000058496.8 Taok1 ENSMUST00000058496.8 TAO kinase 1, transcript variant 3 (from RefSeq NM_144825.3) ENSMUST00000058496.1 ENSMUST00000058496.2 ENSMUST00000058496.3 ENSMUST00000058496.4 ENSMUST00000058496.5 ENSMUST00000058496.6 ENSMUST00000058496.7 Kiaa1361 NM_144825 Q5F2E8 Q69ZL2 Q8JZX2 Q91VG7 TAOK1_MOUSE uc007khc.1 uc007khc.2 Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade (By similarity). During fetal development, it plays an essential role in the regulation of neuronal differentiation and migration to the cortical plate (PubMed:33565190). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Serine/threonine-protein kinase activity is inhibited by SPRED1. Self-associates. Interacts with MAP2K3. Interacts with SPRED1 (By similarity). Interacts with TESK1; the interaction inhibits TAOK1 kinase activity (By similarity). Interacts with MAP3K7 (By similarity). Cytoplasm Proteolytically processed by caspase-3 (CASP3). Autophosphorylated (By similarity). Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Sequence=AAH16522.1; Type=Erroneous initiation; Evidence=; Sequence=BAD32434.1; Type=Erroneous initiation; Evidence=; MAPK cascade nucleotide binding activation of MAPKK activity microtubule cytoskeleton organization protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity ATP binding nucleus cytoplasm DNA repair protein phosphorylation apoptotic process cellular response to DNA damage stimulus negative regulation of microtubule depolymerization mitotic G2 DNA damage checkpoint protein C-terminus binding microtubule cytoskeleton kinase activity phosphorylation transferase activity protein kinase binding signal transduction by protein phosphorylation protein kinase activator activity myosin V binding activation of protein kinase activity positive regulation of stress-activated MAPK cascade regulation of actin cytoskeleton organization alpha-tubulin binding protein serine/threonine kinase activator activity positive regulation of JNK cascade protein autophosphorylation perinuclear region of cytoplasm beta-tubulin binding regulation of cytoskeleton organization neuron cellular homeostasis regulation of microtubule cytoskeleton organization execution phase of apoptosis positive regulation of protein acetylation uc007khc.1 uc007khc.2 
ENSMUST00000058524.3 Zc3hav1l ENSMUST00000058524.3 zinc finger CCCH-type, antiviral 1-like (from RefSeq NM_172467.3) ENSMUST00000058524.1 ENSMUST00000058524.2 NM_172467 Q8BFR1 Q8C3Z2 ZCCHL_MOUSE uc009bjx.1 uc009bjx.2 uc009bjx.3 uc009bjx.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BFR1-1; Sequence=Displayed; Name=2; IsoId=Q8BFR1-2; Sequence=VSP_033212; Despite its name, it does not contain a canonical C3H1-type zinc-finger. molecular_function cytosol biological_process metal ion binding uc009bjx.1 uc009bjx.2 uc009bjx.3 uc009bjx.4 
ENSMUST00000058534.7 Med26 ENSMUST00000058534.7 mediator complex subunit 26 (from RefSeq NM_027485.4) Crsp7 ENSMUST00000058534.1 ENSMUST00000058534.2 ENSMUST00000058534.3 ENSMUST00000058534.4 ENSMUST00000058534.5 ENSMUST00000058534.6 MED26_MOUSE NM_027485 Q7TN02 Q8BUP9 Q8R1G7 Q9CS67 uc009mgg.1 uc009mgg.2 uc009mgg.3 uc009mgg.4 uc009mgg.5 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Interacts with CEBPB (when not methylated)(PubMed:20111005). Nucleus Belongs to the Mediator complex subunit 26 family. transcription cofactor activity nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter positive regulation of gene expression mediator complex core mediator complex uc009mgg.1 uc009mgg.2 uc009mgg.3 uc009mgg.4 uc009mgg.5 
ENSMUST00000058535.6 Gpr149 ENSMUST00000058535.6 G protein-coupled receptor 149, transcript variant 1 (from RefSeq NM_177346.5) ENSMUST00000058535.1 ENSMUST00000058535.2 ENSMUST00000058535.3 ENSMUST00000058535.4 ENSMUST00000058535.5 GP149_MOUSE NM_177346 Pgr10 Q3TMB1 Q3UVY1 Q80T52 Q8BXA3 Q8BZC0 uc008pjo.1 uc008pjo.2 uc008pjo.3 Orphan receptor. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Sequence=BAC33315.1; Type=Erroneous initiation; Evidence=; preantral ovarian follicle growth antral ovarian follicle growth G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway membrane integral component of membrane peptide binding neuropeptide binding negative regulation of ovulation uc008pjo.1 uc008pjo.2 uc008pjo.3 
ENSMUST00000058550.15 Ccni ENSMUST00000058550.15 cyclin I, transcript variant 1 (from RefSeq NM_017367.4) CCNI_MOUSE ENSMUST00000058550.1 ENSMUST00000058550.10 ENSMUST00000058550.11 ENSMUST00000058550.12 ENSMUST00000058550.13 ENSMUST00000058550.14 ENSMUST00000058550.2 ENSMUST00000058550.3 ENSMUST00000058550.4 ENSMUST00000058550.5 ENSMUST00000058550.6 ENSMUST00000058550.7 ENSMUST00000058550.8 ENSMUST00000058550.9 G3X985 NM_017367 Q9Z2V9 uc008yed.1 uc008yed.2 uc008yed.3 Belongs to the cyclin family. regulation of cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein kinase holoenzyme complex nucleus cytoplasm protein phosphorylation cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding mitotic cell cycle phase transition regulation of cell cycle protein kinase activity uc008yed.1 uc008yed.2 uc008yed.3 
ENSMUST00000058577.5 Proser1 ENSMUST00000058577.5 proline and serine rich 1 (from RefSeq NM_173382.2) ENSMUST00000058577.1 ENSMUST00000058577.2 ENSMUST00000058577.3 ENSMUST00000058577.4 NM_173382 PRSR1_MOUSE Proser1 Q3UGD1 Q5PRE5 Q6PFH9 Q80WX5 Q8BYT2 uc008pev.1 uc008pev.2 uc008pev.3 Mediates OGT interaction with and O-GlcNAcylation of TET2 to control TET2 stabilization at enhancers and CpG islands (CGIs). Interacts with TET2 and OGT; this interaction mediates TET2 O- GlcNAcylation and stability by promoting the interaction between OGT and TET2. Interacts with KDM6A. Interacts with TET1. Glycosylated. Interaction with OGT leads to GlcNAcylation. Sequence=BAC29986.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component biological_process uc008pev.1 uc008pev.2 uc008pev.3 
ENSMUST00000058578.8 Pgrmc2 ENSMUST00000058578.8 progesterone receptor membrane component 2 (from RefSeq NM_027558.2) ENSMUST00000058578.1 ENSMUST00000058578.2 ENSMUST00000058578.3 ENSMUST00000058578.4 ENSMUST00000058578.5 ENSMUST00000058578.6 ENSMUST00000058578.7 NM_027558 PGRC2_MOUSE Pgrmc2 Q80UU9 uc008pce.1 uc008pce.2 uc008pce.3 Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (PubMed:28005395). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (PubMed:31748741). Interacts with PGRMC1 (PubMed:31748741). Interacts with AAAS (By similarity). Membrane ; Single-pass membrane protein Nucleus envelope Endoplasmic reticulum Secreted Expressed in brown adipose tissue, white adipose tissue, liver, heart, skeletal muscle, brain and adrenal gland. The cytochrome b5 heme-binding domain lacks the conserved iron- binding His residues at positions 131 and 155. Adipose tissue-specific knockout mice adapted to 30 degrees Celsius show no difference in body weight or white adipose tissue (WAT) mass but have reduced brown adipose tissue (BAT) weight relative to their wild-type littermates. BAT loses its distinctive reddish color. In contrast to wild-type mice, which activate thermogenesis and preserve body temperature when exposed to cold (4 degrees Celsius), mutants rapidly become hypothermic and die if not rescued. They have a total heme content reduced of about 60%. Mutants housed at room temperature and fed a high-fat diet (HFD) show no differences in body weight or composition, except for decreased BAT mass. However, they have higher fasting glycaemia and decreased glucose tolerance and insulin sensitivity. They also exhibit hyperlipidaemia and exacerbated liver steatosis with about 70% more triglycerides (PubMed:31748741). Conditional knockout from female reproductive tissues results in postimplantation embryonic death leading to subfertility, with female mice producing 47% fewer pups/litter than wild-types. They undergo premature reproductive senescence by parities 2 to 5, producing 37.8% fewer litters overall during the trial compared with wild-types (PubMed:28005395). Double conditional knockout for PGRMC1 and PGRMC2 from female reproductive tissues results in postimplantation embryonic death leading to subfertility, with female mice producing fewer pups/litter than wild-types. They undergo premature reproductive senescence, producing fewer litters overall during the trial compared with wild-types (PubMed:28005395). Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). Belongs to the cytochrome b5 family. MAPR subfamily. steroid binding protein binding nuclear envelope biological_process lipid binding membrane integral component of membrane uc008pce.1 uc008pce.2 uc008pce.3 
ENSMUST00000058579.7 Ddx28 ENSMUST00000058579.7 DEAD box helicase 28 (from RefSeq NM_028038.3) DDX28_MOUSE ENSMUST00000058579.1 ENSMUST00000058579.2 ENSMUST00000058579.3 ENSMUST00000058579.4 ENSMUST00000058579.5 ENSMUST00000058579.6 NM_028038 Q0VBM0 Q3TQM0 Q9CWT6 uc009nez.1 uc009nez.2 uc009nez.3 uc009nez.4 Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Monomer. Found in a complex with GRSF1, DHX30, FASTKD2 and FASTKD5. Associates with the 16S mitochondrial rRNA (16S mt-rRNA) and with the mitochondrial ribosome large subunit (39S). Nucleus Mitochondrion Mitochondrion matrix, mitochondrion nucleoid Mitochondrion matrix Note=Transported between these two compartments. Nuclear localization depends on active RNA polymerase II transcription. Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids (By similarity). Belongs to the DEAD box helicase family. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus nucleolus mitochondrion mitochondrial matrix cytosol hydrolase activity rRNA binding ribonucleoprotein granule ribosome biogenesis mitochondrial nucleoid mitochondrial large ribosomal subunit assembly uc009nez.1 uc009nez.2 uc009nez.3 uc009nez.4 
ENSMUST00000058593.10 Egflam ENSMUST00000058593.10 EGF-like, fibronectin type III and laminin G domains, transcript variant 2 (from RefSeq NM_178748.7) B2RWU6 B6JU28 EGFLA_MOUSE ENSMUST00000058593.1 ENSMUST00000058593.2 ENSMUST00000058593.3 ENSMUST00000058593.4 ENSMUST00000058593.5 ENSMUST00000058593.6 ENSMUST00000058593.7 ENSMUST00000058593.8 ENSMUST00000058593.9 NM_178748 Q4VBE4 Q80WX4 Q8BGP3 uc007vea.1 uc007vea.2 uc007vea.3 uc007vea.4 Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception (PubMed:18641643, PubMed:18757743, PubMed:30282023). Plays a key role in the synaptic organization of photoreceptors by mediating transsynaptic interaction between alpha-dystroglycan and GPR179 on the postsynaptic membrane (PubMed:30282023). Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse (PubMed:18641643, PubMed:18757743, PubMed:30282023). Promotes matrix assembly and cell adhesiveness (PubMed:18641643, PubMed:18757743). Interacts with DAG1 alpha-dystroglycan (PubMed:18641643). Interacts with GPR158 and GPR179; transsynaptic interaction is required for synaptic organization of photoreceptor cells (PubMed:30282023). Q4VBE4; PRO_0000021067 [Q62165]: Dag1; NbExp=2; IntAct=EBI-2025048, EBI-2025154; Q4VBE4; Q6PRD1: GPR179; Xeno; NbExp=4; IntAct=EBI-2025048, EBI-20895185; Secreted, extracellular space, extracellular matrix Synaptic cleft Presynaptic active zone Note=Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells (PubMed:18641643). Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals (PubMed:18641643). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q4VBE4-1; Sequence=Displayed; Name=2; IsoId=Q4VBE4-2; Sequence=VSP_028482; Expressed in the outer plexiform layer (first synaptic region) but not in the inner plexiform layer (second synaptic region) of the retina (at protein level). Strongly expressed in the photoreceptor layer of the retina. Moderately expressed in pineal gland and brain. Weakly expressed in lung and ovary. Expressed in the apical side of the neuroblastic layer (NBL) of the retina at 14.5 dpc and 17.5 dpc. At 16.5 dpc, present in rib cartilage and hair follicle (at protein level). O-glycosylated; contains chondroitin sulfate and heparan sulfate. No morphological abnormalities (PubMed:18641643). Knockout mice are viable and fertile (PubMed:18641643). However, the terminal of bipolar cells do not appose to the synapse terminals in the rod photoreceptor ribbon synapses (PubMed:18641643). The signal transmission from the rod photoreceptor to the rod bipolar cells is less sensitive and is delayed compared to the wild type mouse (PubMed:18641643). The signal transmission from cone photoreceptors to the cone bipolar cells is also impaired (PubMed:18641643). These mice show reduced visual function (PubMed:18641643). Impaired stability and postsynaptic targeting of GPR179 (PubMed:30282023). calcium ion binding protein binding glycosaminoglycan binding extracellular region basement membrane interstitial matrix motor neuron axon guidance animal organ morphogenesis tissue development positive regulation of cell-substrate adhesion dendrite development peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan cell junction extracellular matrix organization extracellular matrix synapse uc007vea.1 uc007vea.2 uc007vea.3 uc007vea.4 
ENSMUST00000058595.7 Ifnk ENSMUST00000058595.7 interferon kappa (from RefSeq NM_199157.2) ENSMUST00000058595.1 ENSMUST00000058595.2 ENSMUST00000058595.3 ENSMUST00000058595.4 ENSMUST00000058595.5 ENSMUST00000058595.6 IFNK_MOUSE NM_199157 Q7TSL0 uc008sgu.1 uc008sgu.2 uc008sgu.3 May play a role in the regulation of immune cell function. Secreted Expressed at low levels in peritoneal macrophages. Upon exposure to double-stranded RNA and interferon-gamma. Transgenic mice overexpressing IFNK in the pancreas, develop insulin-dependent (type I) diabete. Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space regulation of transcription, DNA-templated defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008sgu.1 uc008sgu.2 uc008sgu.3 
ENSMUST00000058600.4 Foxd4 ENSMUST00000058600.4 forkhead box D4 (from RefSeq NM_008022.3) B2RRJ0 ENSMUST00000058600.1 ENSMUST00000058600.2 ENSMUST00000058600.3 FOXD4_MOUSE Fkh2 Fkhl9 Freac5 NM_008022 Q60688 Q61573 uc008hav.1 uc008hav.2 uc008hav.3 Nucleus. Not detected in any adult tissues tested. Expressed in headfold stage embryos in the notochord, the anterior neuroectoderm, and a few cells of the definite endoderm. This expression becomes restricted to the anteriormost portions of the invaginating foregut and the developing midbrain. From day 11.5 of gestation onward, FOXD4 transcripts are restricted to the midbrain and become progressively localized to the red nuclei as the sole site of expression. Contains two potential transactivation domains A and B. RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter anatomical structure morphogenesis cell differentiation sequence-specific DNA binding uc008hav.1 uc008hav.2 uc008hav.3 
ENSMUST00000058605.3 Skint9 ENSMUST00000058605.3 selection and upkeep of intraepithelial T cells 9 (from RefSeq NM_177864.3) A7TZG3 ENSMUST00000058605.1 ENSMUST00000058605.2 NM_177864 SKIT9_MOUSE uc008udv.1 uc008udv.2 May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. Membrane ; Multi-pass membrane protein Expressed in skin, thymus and testis. Encoded by one of the 11 copies of Skint genes clustered in the D1 region of the chromosome 4. Belongs to the SKINT family. receptor binding external side of plasma membrane membrane integral component of membrane regulation of immune response T cell receptor signaling pathway uc008udv.1 uc008udv.2 
ENSMUST00000058610.8 Ucn3 ENSMUST00000058610.8 urocortin 3 (from RefSeq NM_031250.5) ENSMUST00000058610.1 ENSMUST00000058610.2 ENSMUST00000058610.3 ENSMUST00000058610.4 ENSMUST00000058610.5 ENSMUST00000058610.6 ENSMUST00000058610.7 NM_031250 Q924A4 UCN3_MOUSE uc007pjh.1 uc007pjh.2 uc007pjh.3 This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. The pancreatic islets isolated from mice lacking the encoded protein secrete less insulin in response to high glucose concentrations. Transgenic mice overexpressing the encoded protein exhibit a metabolically favorable phenotype resisting obesity and hyperglycemia on a high-fat diet. [provided by RefSeq, Sep 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK148451.1, BY741576.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity). Binds with high affinity to CRF receptors 2-alpha and 2-beta. Secreted. Expressed in some areas of the brain including the hypothalamus, amygdala, and brainstem, but is not evident in the cerebellum, pituitary, or cerebral cortex; it is also expressed peripherally in small intestine and skin. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. hormone activity neuropeptide hormone activity protein binding extracellular region extracellular space adenylate cyclase-activating G-protein coupled receptor signaling pathway neuropeptide signaling pathway digestion response to glucose hormone-mediated signaling pathway axon cellular response to nutrient levels positive regulation of insulin secretion response to immobilization stress response to starvation neuron projection varicosity axon terminus positive regulation of membrane potential response to corticosterone corticotropin-releasing hormone receptor binding corticotropin-releasing hormone receptor 2 binding cellular response to hypoxia uc007pjh.1 uc007pjh.2 uc007pjh.3 
ENSMUST00000058615.10 Cir1 ENSMUST00000058615.10 corepressor interacting with RBPJ, 1 (from RefSeq NM_025854.4) CIR1_MOUSE Cir ENSMUST00000058615.1 ENSMUST00000058615.2 ENSMUST00000058615.3 ENSMUST00000058615.4 ENSMUST00000058615.5 ENSMUST00000058615.6 ENSMUST00000058615.7 ENSMUST00000058615.8 ENSMUST00000058615.9 NM_025854 Q3V2N9 Q4KL44 Q52KL9 Q5FW66 Q9DA19 uc008kck.1 uc008kck.2 uc008kck.3 uc008kck.4 Regulates transcription and acts as a corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre- mRNAs. Interacts with RP9, SNW1, SFRS1, SFRS2,U2AF1, RBPJ, SAP30, HDAC2 NKAP and NEK6. Interacts with Epstein-Barr virus RPMS1. Component of the histone deacetylase complex. Component of the Notch corepressor complex. Interacts with NKAPL (PubMed:25875095). Q9DA19; P97762: rp9; NbExp=6; IntAct=EBI-309693, EBI-626715; Nucleus speckle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with NEK6 in the centrosome. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DA19-1; Sequence=Displayed; Name=2; IsoId=Q9DA19-3; Sequence=VSP_020093; Phosphorylated by NEK6. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=AAH94283.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; negative regulation of transcription from RNA polymerase II promoter in utero embryonic development transcription corepressor activity protein binding nucleus cytoplasm centrosome microtubule organizing center cytoskeleton mRNA processing RNA splicing nuclear speck protein kinase binding macromolecular complex histone deacetylase binding macromolecular complex binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc008kck.1 uc008kck.2 uc008kck.3 uc008kck.4 
ENSMUST00000058635.5 Slc25a2 ENSMUST00000058635.5 solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2 (from RefSeq NM_001159275.1) ENSMUST00000058635.1 ENSMUST00000058635.2 ENSMUST00000058635.3 ENSMUST00000058635.4 NM_001159275 Ornt2 Q99ML6 Q99ML6_MOUSE Slc25a2 uc008eqh.1 uc008eqh.2 uc008eqh.3 uc008eqh.4 Membrane ; Multi- pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. L-ornithine transmembrane transporter activity mitochondrion membrane integral component of membrane mitochondrial L-ornithine transmembrane transport uc008eqh.1 uc008eqh.2 uc008eqh.3 uc008eqh.4 
ENSMUST00000058636.9 Helt ENSMUST00000058636.9 helt bHLH transcription factor (from RefSeq NM_173789.4) ENSMUST00000058636.1 ENSMUST00000058636.2 ENSMUST00000058636.3 ENSMUST00000058636.4 ENSMUST00000058636.5 ENSMUST00000058636.6 ENSMUST00000058636.7 ENSMUST00000058636.8 HELT_MOUSE Hesl Mgn NM_173789 Q7TS99 uc009lqd.1 uc009lqd.2 uc009lqd.3 uc009lqd.4 Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Required for the development of GABAergic neurons. Self-associates. Interacts with HES5 and HEY2. Nucleus Expressed in heart and testis. Expressed in the progenitor domains for mesencephalic GABAergic neurons. Death between 2 and 5 weeks of age. The mesencephalic GABAergic progenitors in these animals fail to develop into neurons. Belongs to the HEY family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding suckling behavior DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated multicellular organism development nervous system development central nervous system development post-embryonic development anterior/posterior pattern specification multicellular organism aging gene expression GABAergic neuron differentiation in basal ganglia cell differentiation neuron differentiation multicellular organism growth protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter protein dimerization activity regulation of neurogenesis uc009lqd.1 uc009lqd.2 uc009lqd.3 uc009lqd.4 
ENSMUST00000058639.11 Vcpkmt ENSMUST00000058639.11 valosin containing protein lysine (K) methyltransferase, transcript variant 6 (from RefSeq NR_166437.1) B2RSP0 ENSMUST00000058639.1 ENSMUST00000058639.10 ENSMUST00000058639.2 ENSMUST00000058639.3 ENSMUST00000058639.4 ENSMUST00000058639.5 ENSMUST00000058639.6 ENSMUST00000058639.7 ENSMUST00000058639.8 ENSMUST00000058639.9 Gm71 MT21D_MOUSE Mettl21d NR_166437 Q3UML0 Q8C436 uc007nsl.1 uc007nsl.2 uc007nsl.3 Protein N-lysine methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity. Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54193; Evidence=; Interacts with ALKBH6. Interacts with ASPSCR1 and UBXN6; interaction with ASPSCR1, but not with UBXN6, enhances VCP methylation. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C436-1; Sequence=Displayed; Name=2; IsoId=Q8C436-2; Sequence=VSP_026588; Widely expressed. Deficient mice are viable, fertile and have no obvious pathological phenotype. Belongs to the methyltransferase superfamily. METTL21 family. cytoplasm cytosol methyltransferase activity protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine methylation peptidyl-lysine trimethylation methylation negative regulation of ATPase activity macromolecular complex ATPase binding uc007nsl.1 uc007nsl.2 uc007nsl.3 
ENSMUST00000058643.4 Fbxo43 ENSMUST00000058643.4 F-box protein 43, transcript variant 1 (from RefSeq NM_001368658.1) ENSMUST00000058643.1 ENSMUST00000058643.2 ENSMUST00000058643.3 Fbxo43 G3X9B2 G3X9B2_MOUSE NM_001368658 uc007vmk.1 uc007vmk.2 Protein modification; protein ubiquitination. metal ion binding uc007vmk.1 uc007vmk.2 
ENSMUST00000058651.5 Lao1 ENSMUST00000058651.5 L-amino acid oxidase 1 (from RefSeq NM_133892.4) B1ARV3 B1ARV3_MOUSE ENSMUST00000058651.1 ENSMUST00000058651.2 ENSMUST00000058651.3 ENSMUST00000058651.4 Lao1 NM_133892 uc008uld.1 uc008uld.2 uc008uld.3 uc008uld.4 Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Belongs to the flavin monoamine oxidase family. L-amino-acid oxidase activity extracellular region cellular amino acid catabolic process oxidoreductase activity oxidation-reduction process uc008uld.1 uc008uld.2 uc008uld.3 uc008uld.4 
ENSMUST00000058652.6 Hs3st3a1 ENSMUST00000058652.6 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 (from RefSeq NM_178870.5) 3ost3a1 ENSMUST00000058652.1 ENSMUST00000058652.2 ENSMUST00000058652.3 ENSMUST00000058652.4 ENSMUST00000058652.5 HS3SA_MOUSE Hs3st3a NM_178870 Q8BKN6 uc007jkr.1 uc007jkr.2 uc007jkr.3 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike HS3ST1/3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:15461, Rhea:RHEA- COMP:9830, Rhea:RHEA-COMP:9831, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:70975; EC=2.8.2.23; Evidence=; Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the sulfotransferase 1 family. Golgi membrane cellular_component Golgi apparatus sulfotransferase activity [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity membrane integral component of membrane transferase activity uc007jkr.1 uc007jkr.2 uc007jkr.3 
ENSMUST00000058659.9 Tst ENSMUST00000058659.9 thiosulfate sulfurtransferase, mitochondrial (from RefSeq NM_009437.5) ENSMUST00000058659.1 ENSMUST00000058659.2 ENSMUST00000058659.3 ENSMUST00000058659.4 ENSMUST00000058659.5 ENSMUST00000058659.6 ENSMUST00000058659.7 ENSMUST00000058659.8 NM_009437 Q545S0 Q545S0_MOUSE Tst uc007wpd.1 uc007wpd.2 uc007wpd.3 Reaction=hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate; Xref=Rhea:RHEA:16881, ChEBI:CHEBI:15378, ChEBI:CHEBI:17359, ChEBI:CHEBI:18022, ChEBI:CHEBI:18407, ChEBI:CHEBI:33542; EC=2.8.1.1; Evidence=; Monomer. Mitochondrion matrix thiosulfate sulfurtransferase activity mitochondrion 5S rRNA binding transferase activity epithelial cell differentiation rRNA import into mitochondrion rRNA transport uc007wpd.1 uc007wpd.2 uc007wpd.3 
ENSMUST00000058661.14 Slc25a41 ENSMUST00000058661.14 solute carrier family 25, member 41, transcript variant 1 (from RefSeq NM_175333.3) B8ZHC8 ENSMUST00000058661.1 ENSMUST00000058661.10 ENSMUST00000058661.11 ENSMUST00000058661.12 ENSMUST00000058661.13 ENSMUST00000058661.2 ENSMUST00000058661.3 ENSMUST00000058661.4 ENSMUST00000058661.5 ENSMUST00000058661.6 ENSMUST00000058661.7 ENSMUST00000058661.8 ENSMUST00000058661.9 NM_175333 Q14BV4 Q8BVN7 S2541_MOUSE SCaMC3L Slc25a41 uc008dds.1 uc008dds.2 uc008dds.3 Calcium-independent ATP-Mg/Pi exchanger that catalyzes the electroneutral exchange of Mg-ATP or free ADP against an hydrogenphosphate and participates in the net transport of adenine nucleotides across the mitochondria inner membrane. Reaction=ATP(out) + Mg(2+)(out) + phosphate(in) = ATP(in) + Mg(2+)(in) + phosphate(out); Xref=Rhea:RHEA:65840, ChEBI:CHEBI:18420, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474; Evidence=; Reaction=ADP(out) + H(+)(out) + phosphate(in) = ADP(in) + H(+)(in) + phosphate(out); Xref=Rhea:RHEA:65844, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Kinetic parameters: KM=0.41 mM for ATP ; KM=0.9 mM for ADP ; Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8BVN7-1; Sequence=Displayed; Name=2 ; IsoId=Q8BVN7-2; Sequence=VSP_052684; Mainly expressed in testis and at lesser levels in brain. Belongs to the mitochondrial carrier (TC 2.A.29) family. ATP transmembrane transporter activity mitochondrion mitochondrial inner membrane ATP transport membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008dds.1 uc008dds.2 uc008dds.3 
ENSMUST00000058667.15 Lrrc4b ENSMUST00000058667.15 leucine rich repeat containing 4B (from RefSeq NM_198250.1) ENSMUST00000058667.1 ENSMUST00000058667.10 ENSMUST00000058667.11 ENSMUST00000058667.12 ENSMUST00000058667.13 ENSMUST00000058667.14 ENSMUST00000058667.2 ENSMUST00000058667.3 ENSMUST00000058667.4 ENSMUST00000058667.5 ENSMUST00000058667.6 ENSMUST00000058667.7 ENSMUST00000058667.8 ENSMUST00000058667.9 LRC4B_MOUSE Lrig4 NM_198250 P0C192 uc009gpj.1 uc009gpj.2 uc009gpj.3 uc009gpj.4 Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity). Interacts with PTPRF (By similarity). Interacts with DLG4. Membrane; Single-pass membrane protein. Presynaptic cell membrane The extreme C-terminus binds to the first 2 PDZ domains of DLG4. N-glycosylated. O-glycosylated; contains sialic acid. receptor binding protein binding plasma membrane membrane integral component of membrane cell junction presynaptic membrane cerebellar mossy fiber synapse positive regulation of synapse assembly glutamatergic synapse integral component of postsynaptic density membrane synaptic membrane adhesion regulation of presynapse assembly uc009gpj.1 uc009gpj.2 uc009gpj.3 uc009gpj.4 
ENSMUST00000058669.15 Gnat2 ENSMUST00000058669.15 G protein subunit alpha transducin 2 (from RefSeq NM_008141.3) ENSMUST00000058669.1 ENSMUST00000058669.10 ENSMUST00000058669.11 ENSMUST00000058669.12 ENSMUST00000058669.13 ENSMUST00000058669.14 ENSMUST00000058669.2 ENSMUST00000058669.3 ENSMUST00000058669.4 ENSMUST00000058669.5 ENSMUST00000058669.6 ENSMUST00000058669.7 ENSMUST00000058669.8 ENSMUST00000058669.9 GNAT2_MOUSE NM_008141 P50149 uc008qyc.1 uc008qyc.2 uc008qyc.3 uc008qyc.4 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP- phosphodiesterase. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Cell projection, cilium, photoreceptor outer segment Photoreceptor inner segment Note=Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark- adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light. In the retina, expressed in the rod photoreceptors. Belongs to the G-alpha family. G(i/o/t/z) subfamily. nucleotide binding detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor binding photoreceptor outer segment photoreceptor inner segment GTPase activity GTP binding heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger positive regulation of cytosolic calcium ion concentration visual perception phototransduction response to light intensity membrane guanyl nucleotide binding G-protein beta/gamma-subunit complex binding retinal cone cell development metal ion binding response to stimulus detection of light stimulus involved in visual perception uc008qyc.1 uc008qyc.2 uc008qyc.3 uc008qyc.4 
ENSMUST00000058678.5 Ppp1r3d ENSMUST00000058678.5 protein phosphatase 1, regulatory subunit 3D (from RefSeq NM_001085501.2) A2AJW4 A2AJW4_MOUSE ENSMUST00000058678.1 ENSMUST00000058678.2 ENSMUST00000058678.3 ENSMUST00000058678.4 NM_001085501 Ppp1r3d uc008ohp.1 uc008ohp.2 uc008ohp.3 uc008ohp.4 phosphoprotein phosphatase activity carbohydrate metabolic process glycogen metabolic process regulation of glycogen biosynthetic process regulation of glycogen catabolic process protein dephosphorylation enzyme binding glycogen granule intracellular membrane-bounded organelle uc008ohp.1 uc008ohp.2 uc008ohp.3 uc008ohp.4 
ENSMUST00000058679.7 Mtmr9 ENSMUST00000058679.7 myotubularin related protein 9 (from RefSeq NM_177594.1) A6H6P1 ENSMUST00000058679.1 ENSMUST00000058679.2 ENSMUST00000058679.3 ENSMUST00000058679.4 ENSMUST00000058679.5 ENSMUST00000058679.6 MTMR9_MOUSE Mtmr3 NM_177594 Q80XL4 Q9Z2D0 uc007uht.1 uc007uht.2 uc007uht.3 Acts as an adapter for myotubularin-related phosphatases (PubMed:12890864). Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (By similarity). Positively regulates lipid phosphatase MTMR7 catalytic activity (PubMed:12890864). The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (By similarity). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (By similarity). Negatively regulates DNA damage- induced apoptosis, in part via its association with MTMR6 (By similarity). Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (By similarity). Homodimer (PubMed:12890864). Heterodimer (via C-terminus) with lipid phosphatase MTMR6 (via C-terminus) (PubMed:12890864). Heterodimer (via coiled coil domain) with lipid phosphatase MTMR7 (via C-terminus) (PubMed:12890864). Cytoplasm Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, perinuclear region Endoplasmic reticulum Note=Localizes to ruffles during EGF-induced macropinocytosis (PubMed:24591580). Colocalizes with MTMR6 to the perinuclear region (By similarity). Partially localizes to the endoplasmic reticulum (By similarity). The GRAM domain is required for cell membrane localization. The coiled coil domain mediates interaction with MTMR9. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 333 in the dsPTPase catalytic loop, suggesting that it has no carboxypeptidase activity. Sequence=AAC80003.1; Type=Frameshift; Evidence=; protein binding cytoplasm endoplasmic reticulum cytosol plasma membrane endocytosis negative regulation of autophagy positive regulation of phosphatase activity membrane protein phosphatase binding enzyme regulator activity ruffle membrane macromolecular complex cell projection perinuclear region of cytoplasm protein stabilization regulation of phosphatidylinositol dephosphorylation uc007uht.1 uc007uht.2 uc007uht.3 
ENSMUST00000058682.11 Ano7 ENSMUST00000058682.11 anoctamin 7, transcript variant 2 (from RefSeq NM_001271884.1) ANO7_MOUSE ENSMUST00000058682.1 ENSMUST00000058682.10 ENSMUST00000058682.2 ENSMUST00000058682.3 ENSMUST00000058682.4 ENSMUST00000058682.5 ENSMUST00000058682.6 ENSMUST00000058682.7 ENSMUST00000058682.8 ENSMUST00000058682.9 NM_001271884 Ngep Q14AT5 Q6IFT5 Tmem16g uc033fku.1 uc033fku.2 uc033fku.3 This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. In humans, this protein is primarily found in prostate tissues and may serve as a target for prostate cancer immunotherapy. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Dec 2012]. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium- activated chloride channel (CaCC) activity (PubMed:23532839). May play a role in cell-cell interactions (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38664; Evidence=; Reaction=a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in); Xref=Rhea:RHEA:38899, ChEBI:CHEBI:18390; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38900; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38573; Evidence=; Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum Note=Concentrates at sites of cell-cell contact. Shows an intracellular localization. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14AT5-1; Sequence=Displayed; Name=2; IsoId=Q14AT5-2; Sequence=VSP_026009, VSP_026010; Highly expressed in the stomach. Expressed at low levels in small intestine and large intestine. The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. Belongs to the anoctamin family. intracellular calcium activated chloride channel activity nucleus endoplasmic reticulum plasma membrane chloride transport lipid transport membrane integral component of membrane phospholipid scramblase activity ion transmembrane transport protein dimerization activity calcium activated phospholipid scrambling calcium activated phosphatidylserine scrambling calcium activated phosphatidylcholine scrambling calcium activated galactosylceramide scrambling uc033fku.1 uc033fku.2 uc033fku.3 
ENSMUST00000058704.9 Irgm2 ENSMUST00000058704.9 Immunity-related GTPase that plays important roles in innate immunity and inflammatory response (PubMed:17641048, PubMed:33124769, PubMed:33124745, PubMed:34338548, PubMed:34078740). Acts as a dynamin- like protein that binds to intracellular membranes and promotes remodeling and trafficking of those membranes (By similarity). Required for clearance of acute protozoan and bacterial infections (PubMed:17641048, PubMed:34338548, PubMed:34078740). Acts by participating to Tgtp1/Irgb6 and Gbp1-mediated parasite killing by promoting their accumulation on the T.gondii parasitophorous vacuole membranes (PubMed:34078740). Also required for prolonged loading of ubiquitin and p62/Sqstm1 to parasitophorous vacuole membranes (PubMed:34078740). Also acts as a key negative regulator of the inflammatory response by inhibiting the non-canonical inflammasome, thereby protecting against Casp11-driven septic shock during endotoxemia (PubMed:33124769, PubMed:33124745). (from UniProt A0A140LIF8) A0A140LIF8 AK171724 E9PVI2 ENSMUST00000058704.1 ENSMUST00000058704.2 ENSMUST00000058704.3 ENSMUST00000058704.4 ENSMUST00000058704.5 ENSMUST00000058704.6 ENSMUST00000058704.7 ENSMUST00000058704.8 IRGM2_MOUSE Iigp2 Irgm2 Q3TAN6 Q3TNE5 Q3U635 Q9Z1M2 uc007jat.1 uc007jat.2 uc007jat.3 uc007jat.4 Immunity-related GTPase that plays important roles in innate immunity and inflammatory response (PubMed:17641048, PubMed:33124769, PubMed:33124745, PubMed:34338548, PubMed:34078740). Acts as a dynamin- like protein that binds to intracellular membranes and promotes remodeling and trafficking of those membranes (By similarity). Required for clearance of acute protozoan and bacterial infections (PubMed:17641048, PubMed:34338548, PubMed:34078740). Acts by participating to Tgtp1/Irgb6 and Gbp1-mediated parasite killing by promoting their accumulation on the T.gondii parasitophorous vacuole membranes (PubMed:34078740). Also required for prolonged loading of ubiquitin and p62/Sqstm1 to parasitophorous vacuole membranes (PubMed:34078740). Also acts as a key negative regulator of the inflammatory response by inhibiting the non-canonical inflammasome, thereby protecting against Casp11-driven septic shock during endotoxemia (PubMed:33124769, PubMed:33124745). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Cytoplasmic vesicle membrane Golgi apparatus membrane Cytoplasm, cytosol Note=Localizes to parasitophorous vacuole membranes. Ubiquitinated; polyubiquitinated in the cytosol, promoting Gbp1 recruitment to the T.gondii parasitophorous vacuole membranes. Mice are highly susceptible to T.gondii infection, due to impaired ability to mediate clearance of acute protozoan infections (PubMed:34078740, PubMed:34338548). They also display strongly increased activation of the Casp11-dependent inflammatory responses when exposed to extracellular lipopolysaccharide (LPS), bacterial outer membrane vesicles or Gram-negative bacteria (PubMed:33124745). Mice lacking Irgm1, Irgm2 and Igtp/Irgm3 (panIrgm mice) show resistance against M.tuberculosis one month post-infection; then, panIrgm mice display higher bacterial burden and altered cytokine during late stage of infection, leading to increased mortality (PubMed:36629440). Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. autophagosome assembly Golgi membrane positive regulation of protein phosphorylation GTPase activity GTP binding mitochondrion endoplasmic reticulum membrane Golgi apparatus cytosol defense response response to bacterium positive regulation of autophagy positive regulation of peptidyl-threonine phosphorylation membrane protein kinase binding protein destabilization positive regulation of peptidyl-serine phosphorylation cellular response to interferon-beta defense response to bacterium regulation of protein complex assembly protein serine/threonine kinase activator activity innate immune response CARD domain binding protein stabilization defense response to Gram-negative bacterium BH3 domain binding positive regulation of interferon-gamma-mediated signaling pathway regulation of protein complex stability protein lipidation involved in autophagosome assembly CAMKK-AMPK signaling cascade nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to lipopolysaccharide positive regulation of protein serine/threonine kinase activity autophagy of host cells involved in interaction with symbiont cellular response to virus positive regulation of autophagosome maturation uc007jat.1 uc007jat.2 uc007jat.3 uc007jat.4 
ENSMUST00000058714.10 Cd24a ENSMUST00000058714.10 CD24a antigen (from RefSeq NM_009846.2) Cd24a ENSMUST00000058714.1 ENSMUST00000058714.2 ENSMUST00000058714.3 ENSMUST00000058714.4 ENSMUST00000058714.5 ENSMUST00000058714.6 ENSMUST00000058714.7 ENSMUST00000058714.8 ENSMUST00000058714.9 NM_009846 Q3THW4 Q3THW4_MOUSE uc007ezl.1 uc007ezl.2 immune response cell adhesion external side of plasma membrane anchored component of external side of plasma membrane uc007ezl.1 uc007ezl.2 
ENSMUST00000058725.5 Antxrl ENSMUST00000058725.5 anthrax toxin receptor-like (from RefSeq NM_172808.2) ANTRL_MOUSE E9QNF3 ENSMUST00000058725.1 ENSMUST00000058725.2 ENSMUST00000058725.3 ENSMUST00000058725.4 NM_172808 Q8BVM2 uc007tai.1 uc007tai.2 uc007tai.3 Membrane ; Single-pass type I membrane protein Belongs to the ATR family. transmembrane signaling receptor activity plasma membrane cell surface membrane integral component of membrane signaling receptor activity metal ion binding toxin transport uc007tai.1 uc007tai.2 uc007tai.3 
ENSMUST00000058728.10 Hsd3b8 ENSMUST00000058728.10 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 8 (from RefSeq NM_001270429.1) 3BHS4_MOUSE ENSMUST00000058728.1 ENSMUST00000058728.2 ENSMUST00000058728.3 ENSMUST00000058728.4 ENSMUST00000058728.5 ENSMUST00000058728.6 ENSMUST00000058728.7 ENSMUST00000058728.8 ENSMUST00000058728.9 Hsd3b4 NM_001270429 Q61767 uc008qqa.1 uc008qqa.2 uc008qqa.3 uc008qqa.4 uc008qqa.5 uc008qqa.6 Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase. Reaction=a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH; Xref=Rhea:RHEA:34787, ChEBI:CHEBI:15378, ChEBI:CHEBI:36836, ChEBI:CHEBI:47788, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.270; Evidence=; Reaction=5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta- hydroxy-5alpha-androstan-3-one + H(+) + NADPH; Xref=Rhea:RHEA:16297, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:18329, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.210; Evidence=; Kinetic parameters: KM=2.2 uM for dihydrotestosterone ; Steroid metabolism. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Kidney (at protein level); found only in the cortex, appears to be associated with the proximal tubules; and a minor expression in testis. Expression between 15-20 days post-implantation occurs only in the kidney of the male fetus and not in the female, whereas a similar expression is found in adult male and female kidneys. Belongs to the 3-beta-HSD family. 3-keto sterol reductase activity 3-beta-hydroxy-delta5-steroid dehydrogenase activity steroid binding mitochondrion mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process steroid metabolic process C21-steroid hormone metabolic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor hippocampus development mitochondrial membrane response to stilbenoid intracellular membrane-bounded organelle 5alpha-androstane-3beta,17beta-diol dehydrogenase activity response to corticosterone oxidation-reduction process uc008qqa.1 uc008qqa.2 uc008qqa.3 uc008qqa.4 uc008qqa.5 uc008qqa.6 
ENSMUST00000058735.12 Ubqln1 ENSMUST00000058735.12 ubiquilin 1, transcript variant 1 (from RefSeq NM_026842.4) ENSMUST00000058735.1 ENSMUST00000058735.10 ENSMUST00000058735.11 ENSMUST00000058735.2 ENSMUST00000058735.3 ENSMUST00000058735.4 ENSMUST00000058735.5 ENSMUST00000058735.6 ENSMUST00000058735.7 ENSMUST00000058735.8 ENSMUST00000058735.9 NM_026842 Plic1 Q80V10 Q8C7T4 Q8C835 Q8K141 Q8R317 Q91VI8 Q9D0Z0 Q9QZM1 UBQL1_MOUSE uc007qtm.1 uc007qtm.2 uc007qtm.3 Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the TICAM1/TRIF- dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway. Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down- regulating the ORAI1-mediated Ca2+ mobilization. Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Links CD47 to the cytoskeleton (PubMed:10549293). Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (By similarity). [Isoform 1]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (By similarity). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (By similarity). [Isoform 2]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress. Monomer and homodimer. Heterodimer with UBQLN2 (By similarity). Binds CD47 (PubMed:10549293). Binds NBL1, GABRA1, GABRA2, GABRA3, GABRA6, GABRB1, GABRB2 and GABRB3. Binds UBE3A, BTRC, P4HB and MTOR. Interacts with the proteasome 19S subunit. Interacts (via ubiquitin-like domain) with TREX1; the interaction is direct and may control TREX1 subcellular location. Forms a complex with UBXN4 and VCP. Interacts (via UBA domain) with UBQLN4 (via ubiquitin-like domain). Found in a complex with UBQLN2 and MAP1LC3A/B/C. The monomeric form interacts with PSEN1 and PSEN2. Interacts with ORAI1. Interacts (via UBA domain) with TICAM1. Interacts with EPS15. Interacts (via UBA domain) with UBA52 and (via ubiquitin-like domain) with PSMD3 and PSMD4. Interacts with HERPUD1. Interacts with MAP1LC3A/B/C in the presence of UBQLN4. Interacts (via ubiquitin-like domain) with EPS15 (via UIM domains) and both the ubiquitinated and non-ubiquitinated forms can interact with EPS15. Interacts (via ubiquitin-like domain) with EPS15L1, HGS (via UIM domain) and STAM2 (via UIM domain) (By similarity). Interacts with BCL2L10/BCL-B; in the cytoplasm (By similarity). Nucleus Cytoplasm Endoplasmic reticulum Cytoplasmic vesicle, autophagosome Cell membrane Note=Detected in neuronal processes and at synapses. Recruited to the ER during ER-associated protein degradation (ERAD). Colocalizes with PSEN1 in the cell membrane and in cytoplasmic juxtanuclear structures called aggresomes. Colocalizes with ORAI1 and TICAM1 in the autophagosome. Colocalizes with EPS15 and HGS in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and with EPS15 also in aggresomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R317-1; Sequence=Displayed; Name=2; IsoId=Q8R317-2; Sequence=VSP_009788; Highly expressed in heart, brain, liver, smooth muscle and kidney. The UBA domain mediates binding to PSEN1 and PSEN2. It also binds ubiquitin with micromolar affinity, independently of polyubiquitin linkage type. Essential for its association with microtubule-associated protein 1 light chain 3 (MAP1LC3). The ubiquitin-like domain mediates its association with the subunits of the proteasome. Dimerization is dependent upon the central region of the protein containing the STI1 domains and is independent of its ubiquitin-like and UBA domains. Degraded during both macroautophagy and during chaperone-mediated autophagy (CMA). Phosphorylated. Ubiquitinated. Sequence=AAF01365.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence=; Sequence=AAH51098.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC33666.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; autophagosome assembly proteasome complex receptor binding nucleus nucleoplasm cytoplasm autophagosome endoplasmic reticulum cytosol plasma membrane ubiquitin-dependent protein catabolic process autophagy membrane aggresome macroautophagy regulation of macroautophagy intermediate filament binding kinase binding protein domain specific binding ER-associated ubiquitin-dependent protein catabolic process regulation of protein ubiquitination positive regulation of protein ubiquitination cytoplasmic vesicle polyubiquitin binding macromolecular complex negative regulation of toll-like receptor 3 signaling pathway response to endoplasmic reticulum stress aggrephagy identical protein binding perinuclear region of cytoplasm cellular response to hypoxia autophagosome maturation negative regulation of store-operated calcium channel activity regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of ER-associated ubiquitin-dependent protein catabolic process uc007qtm.1 uc007qtm.2 uc007qtm.3 
ENSMUST00000058738.11 Hs3st5 ENSMUST00000058738.11 heparan sulfate (glucosamine) 3-O-sulfotransferase 5, transcript variant 1 (from RefSeq NM_001253355.1) ENSMUST00000058738.1 ENSMUST00000058738.10 ENSMUST00000058738.2 ENSMUST00000058738.3 ENSMUST00000058738.4 ENSMUST00000058738.5 ENSMUST00000058738.6 ENSMUST00000058738.7 ENSMUST00000058738.8 ENSMUST00000058738.9 HS3S5_MOUSE Hs3ost5 NM_001253355 Q8BSL4 uc007evd.1 uc007evd.2 uc007evd.3 uc007evd.4 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2 (By similarity). Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:15461, Rhea:RHEA- COMP:9830, Rhea:RHEA-COMP:9831, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:70975; EC=2.8.2.23; Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the sulfotransferase 1 family. Golgi membrane cellular_component Golgi apparatus protein sulfation sulfotransferase activity [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity heparan sulfate proteoglycan biosynthetic process, enzymatic modification membrane integral component of membrane transferase activity regulation of viral entry into host cell negative regulation of coagulation uc007evd.1 uc007evd.2 uc007evd.3 uc007evd.4 
ENSMUST00000058747.4 Mettl24 ENSMUST00000058747.4 methyltransferase like 24 (from RefSeq NM_177793.3) ENSMUST00000058747.1 ENSMUST00000058747.2 ENSMUST00000058747.3 MET24_MOUSE NM_177793 Q8CCB5 uc007exd.1 uc007exd.2 Probable methyltransferase. Secreted Belongs to the methyltransferase superfamily. molecular_function cellular_component extracellular region biological_process methyltransferase activity transferase activity methylation uc007exd.1 uc007exd.2 
ENSMUST00000058748.2 Fam124b ENSMUST00000058748.2 family with sequence similarity 124, member B (from RefSeq NM_173425.3) ENSMUST00000058748.1 F124B_MOUSE NM_173425 Q8BLQ0 uc007brb.1 uc007brb.2 uc007brb.3 uc007brb.4 Interacts with CHD7 and CHD8. Nucleus Expressed strongly in lung, at slightly lower levels in heart, kidney, brain and testis, and weakly in liver (at protein level). In brain, highly expressed in cortex, hippocampus, dentate gyrus, caudate putamen and cerebellum (at protein level). At embryonic stage 12.5 dpc, detected in a wide range of tissues including brain, heart, lung, cochlea, dorsal root ganglia, and liver (at protein level). Belongs to the FAM124 family. molecular_function nucleus nucleoplasm mitochondrion biological_process uc007brb.1 uc007brb.2 uc007brb.3 uc007brb.4 
ENSMUST00000058754.9 Zmpste24 ENSMUST00000058754.9 zinc metallopeptidase, STE24 (from RefSeq NM_172700.3) ENSMUST00000058754.1 ENSMUST00000058754.2 ENSMUST00000058754.3 ENSMUST00000058754.4 ENSMUST00000058754.5 ENSMUST00000058754.6 ENSMUST00000058754.7 ENSMUST00000058754.8 FACE1_MOUSE Face1 NM_172700 Q80W54 Q8BJK4 Q8K569 Zmpste24 uc008uny.1 uc008uny.2 uc008uny.3 Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum (PubMed:11923874, PubMed:12235369, PubMed:17652517, PubMed:27462105). Proteolytically removes the C-terminal three residues of farnesylated proteins (PubMed:11399759, PubMed:17652517). Plays also an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses (PubMed:28246125). Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity (PubMed:28246125). Reaction=The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids.; EC=3.4.24.84; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Inhibited by HIV protease inhibitors, such as lopinavir, tipranavir and nelfinavir, leading to defects in lamin A/LMNA maturation and accumulation of prelamin-A/C precursors in cells (PubMed:17652517, PubMed:27462105). This causes defects in nuclear envelope integrity and release of DNA in the cytosol, activating the AIM2 inflammasome (PubMed:27462105). Endoplasmic reticulum membrane ; Multi-pass membrane protein Nucleus inner membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein The metalloprotease domain is constituted by the two C-terminal nuclear regions. Severe growth retardation and premature death (PubMed:11923874). Mice gain weight slowly, appear malnourished and exhibit progressive hair loss (PubMed:12235369). Mice suffer from dilated cardiomyopathy, muscular dystrophy and lipodystrophy due to defects in lamin A/LMNA maturation (PubMed:11923874). Mice also show spontaneous bone fractures and muscle weakness due to defects in lamin A/LMNA maturation (PubMed:12235369). Mutant mice show increased viral protein expression, enhanced viral reporter activity, and higher titers of infectious viral particles (PubMed:28246125). Belongs to the peptidase M48A family. liver development hair follicle development heart morphogenesis ventricular cardiac muscle tissue development cardiac ventricle development growth plate cartilage development double-stranded DNA binding endopeptidase activity metalloendopeptidase activity nucleus nuclear envelope nuclear inner membrane endoplasmic reticulum endoplasmic reticulum membrane DNA repair chromatin organization regulation of transcription, DNA-templated proteolysis inflammatory cell apoptotic process cellular response to DNA damage stimulus nucleus organization nuclear envelope organization regulation of mitotic cell cycle adult walking behavior regulation of heart contraction peptidase activity metallopeptidase activity determination of adult lifespan regulation of cell shape epidermis development regulation of autophagy positive regulation of gene expression negative regulation of gene expression regulation of glucose metabolic process membrane integral component of membrane protein processing hydrolase activity regulation of lipid metabolic process integral component of endoplasmic reticulum membrane bone mineralization prenylated protein catabolic process regulation of bone mineralization regulation of TOR signaling regulation of hormone metabolic process macromolecular complex multicellular organism growth regulation of multicellular organism growth maintenance of rDNA regulation of DNA damage response, signal transduction by p53 class mediator histone H2B acetylation histone H2B-K5 acetylation hypomethylation of CpG island regulation of DNA methylation cellular lipid metabolic process metal ion binding regulation of fibroblast proliferation thymus development cardiac muscle fiber development regulation of defense response to virus neuromuscular process chromosome organization regulation of ventricular cardiac muscle cell membrane repolarization kidney morphogenesis cardiac conduction CAMKK-AMPK signaling cascade regulation of stress-activated protein kinase signaling cascade cellular response to gamma radiation CAAX-box protein processing response to DNA damage checkpoint signaling regulation of histone H4 acetylation regulation of RNA polymerase II regulatory region sequence-specific DNA binding regulation of mitotic cell cycle DNA replication regulation of blood circulation negative regulation of production of miRNAs involved in gene silencing by miRNA calcium ion import into sarcoplasmic reticulum histone H2A phosphorylation regulation of histone H4-K16 acetylation regulation of termination of RNA polymerase I transcription regulation of cellular senescence uc008uny.1 uc008uny.2 uc008uny.3 
ENSMUST00000058755.5 Fzd4 ENSMUST00000058755.5 frizzled class receptor 4 (from RefSeq NM_008055.4) ENSMUST00000058755.1 ENSMUST00000058755.2 ENSMUST00000058755.3 ENSMUST00000058755.4 FZD4_MOUSE NM_008055 Q61088 uc009ifx.1 uc009ifx.2 uc009ifx.3 uc009ifx.4 Receptor for Wnt proteins (PubMed:10097073). Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (PubMed:19837033). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (PubMed:19837033). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (PubMed:19837033). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Interacts with MAGI3 and NDP (PubMed:15035989, PubMed:15195140). Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP) (PubMed:19837033). Interacts (via FZ domain) with TSKU; TSKU competes with WNT2B for binding to FZD4, inhibiting Wnt signaling and repressing peripheral eye development (PubMed:21856951). Interacts with glypican GPC3 (By similarity). Q61088; P0CG48: UBC; Xeno; NbExp=3; IntAct=EBI-7987880, EBI-3390054; Cell membrane ; Multi-pass membrane protein Expressed in chondrocytes. Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. The FZ domain is involved in binding with Wnt ligands. Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. Defects in retinal vascularization. Belongs to the G-protein coupled receptor Fz/Smo family. beta-amyloid binding luteinization blood vessel development vasculogenesis transmembrane signaling receptor activity cytokine receptor activity G-protein coupled receptor activity protein binding plasma membrane cell-cell junction signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway multicellular organism development sensory perception of sound cell surface negative regulation of cell-substrate adhesion membrane integral component of membrane Wnt signaling pathway Wnt-protein binding cytokine-mediated signaling pathway cytokine binding PDZ domain binding dendrite regulation of vascular endothelial growth factor receptor signaling pathway ubiquitin protein ligase binding locomotion involved in locomotory behavior substrate adhesion-dependent cell spreading extracellular matrix-cell signaling non-canonical Wnt signaling pathway signaling receptor activity progesterone secretion protein homodimerization activity Wnt-activated receptor activity positive regulation of JUN kinase activity macromolecular complex binding synapse positive regulation of transcription, DNA-templated protein heterodimerization activity positive regulation of sequence-specific DNA binding transcription factor activity canonical Wnt signaling pathway retina vasculature morphogenesis in camera-type eye cerebellum vasculature morphogenesis retinal blood vessel morphogenesis glutamatergic synapse cellular response to leukemia inhibitory factor uc009ifx.1 uc009ifx.2 uc009ifx.3 uc009ifx.4 
ENSMUST00000058761.6 Krtap31-2 ENSMUST00000058761.6 keratin associated protein 31-2 (from RefSeq NM_001025244.3) ENSMUST00000058761.1 ENSMUST00000058761.2 ENSMUST00000058761.3 ENSMUST00000058761.4 ENSMUST00000058761.5 Krtap31-2 NM_001025244 OTTMUSG00000002177 Q8CAY5 Q8CAY5_MOUSE uc007ljx.1 uc007ljx.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc007ljx.1 uc007ljx.2 
ENSMUST00000058771.13 Lysmd4 ENSMUST00000058771.13 LysM, putative peptidoglycan-binding, domain containing 4, transcript variant B (from RefSeq NM_175215.4) ENSMUST00000058771.1 ENSMUST00000058771.10 ENSMUST00000058771.11 ENSMUST00000058771.12 ENSMUST00000058771.2 ENSMUST00000058771.3 ENSMUST00000058771.4 ENSMUST00000058771.5 ENSMUST00000058771.6 ENSMUST00000058771.7 ENSMUST00000058771.8 ENSMUST00000058771.9 LYSM4_MOUSE NM_175215 Q6PFQ8 Q8CC84 uc009hia.1 uc009hia.2 uc009hia.3 uc009hia.4 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CC84-1; Sequence=Displayed; Name=2; IsoId=Q8CC84-2; Sequence=VSP_020129; molecular_function cellular_component biological_process membrane integral component of membrane uc009hia.1 uc009hia.2 uc009hia.3 uc009hia.4 
ENSMUST00000058777.8 Angptl8 ENSMUST00000058777.8 angiopoietin-like 8 (from RefSeq NM_001080940.1) ANGL8_MOUSE Angptl8 ENSMUST00000058777.1 ENSMUST00000058777.2 ENSMUST00000058777.3 ENSMUST00000058777.4 ENSMUST00000058777.5 ENSMUST00000058777.6 ENSMUST00000058777.7 Gm6484 NM_001080940 Q8R1L8 Rifl uc009omr.1 uc009omr.2 Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577, PubMed:24043787). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (PubMed:24043787). According to a report, may act by promoting ANGPTL3 cleavage (PubMed:23150577). According to another study, not required for cleavage of ANGPTL3 (PubMed:24043787). Interacts with ANGPTL3. Secreted Expressed in liver and fat. Enriched in white and brown adipose tissues. Expressed during adipogenesis. Highly up-regulated following high-fat diet treatment. Down- regulated upon fasting. Strongly induced in the cold environment (4 Degrees Celsius for 4 hours). Proteolytically cleaved at the N-terminus. Reduced levels of serum triglyceride (PubMed:20562862, PubMed:24043787). Mice gain weight more slowly than wild-type littermates due to a reduction in adipose tissue accretion. Plasma levels of triglycerides are similar to wild-type animals in the fasted state but decreased after refeeding. The lower triglyceride levels are associated with a reduction in very low density lipoprotein secretion and an increase in lipoprotein lipase (LPL) activity (PubMed:24043787). Glucose and insulin tolerance are not affected and no alterations in glucose homeostasis are observed in mice fed either a chow or high fat diet (PubMed:24043787). Moreover, deletion does not affect the compensatory proliferation of pancreatic beta cells in response to insulin resistance induced by a high-fat diet or treatment with the insulin antagonist S961 (PubMed:25417115). Belongs to the ANGPTL8 family. Initially reported to specifically promote pancreatic beta cell proliferation without insulin resistance and to promote beta cell mass expansion, thereby improving glucose tolerance (PubMed:23623304). However, this result could not be confirmed by further studies and the original paper was later retracted (PubMed:28038792). The lack of a role in beta cell proliferation was also confirmed in another study (PubMed:25417115). hormone activity extracellular region lipid metabolic process signal transduction positive regulation of protein processing regulation of lipid metabolic process cellular lipid metabolic process fat cell differentiation cell maturation regulation of lipoprotein metabolic process negative regulation of lipoprotein lipase activity triglyceride homeostasis glucose metabolic process type B pancreatic cell proliferation uc009omr.1 uc009omr.2 
ENSMUST00000058785.10 Cyp4a10 ENSMUST00000058785.10 cytochrome P450, family 4, subfamily a, polypeptide 10 (from RefSeq NM_010011.3) A2A976 CP4AA_MOUSE Cyp4a-10 Cyp4a10 ENSMUST00000058785.1 ENSMUST00000058785.2 ENSMUST00000058785.3 ENSMUST00000058785.4 ENSMUST00000058785.5 ENSMUST00000058785.6 ENSMUST00000058785.7 ENSMUST00000058785.8 ENSMUST00000058785.9 NM_010011 O88833 Q9DCS5 uc008uey.1 uc008uey.2 uc008uey.3 uc008uey.4 A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long-chain fatty acids (By similarity). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:17112342) (By similarity). In kidney, may play an important role in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (By similarity). Also participates in the formation of anti-inflammatory hydroxyepoxyeicosatrienoic acids (HEETs) in kidney by converting 8,9- epoxyeicosatrienoic acid (EET) to 20,8,9-HEET, an activator of PPARA. Displays substantially lower fatty acid omega-1 hydroxylase activity (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Reaction=an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH-- hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:56748, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:140991, ChEBI:CHEBI:140992; EC=1.14.14.80; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56749; Evidence=; Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38947, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:36204, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38948; Evidence=; Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39751, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76628; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39752; Evidence=; Reaction=O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:40203, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30807, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77033; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40204; Evidence=; Reaction=hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:40199, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:55329, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.80; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40200; Evidence=; Reaction=(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:41728, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30823, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78424; EC=1.14.14.80; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41729; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:60580, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132029; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60581; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:60932, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:144041; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60933; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39755, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76624; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39756; Evidence=; Reaction=8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH-- hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)- eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53572, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:84025, ChEBI:CHEBI:137474; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53573; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Kinetic parameters: KM=2 uM for dodecanoate ; Vmax=55 nmol/min/nmol enzyme toward dodecanoate ; Endoplasmic reticulum membrane ; Multi-pass membrane protein Microsome membrane ; Multi-pass membrane protein Highly expressed in the kidneys of both genders. Mutant mice are hypertensive due to constitutive activation of renal epithelial sodium channels and increased sodium reabsorption. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane fatty acid metabolic process arachidonic acid monooxygenase activity arachidonic acid epoxygenase activity membrane apical plasma membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen alkane 1-monooxygenase activity heme binding organelle membrane leukotriene B4 catabolic process intracellular membrane-bounded organelle metal ion binding leukotriene-B4 20-monooxygenase activity oxidation-reduction process uc008uey.1 uc008uey.2 uc008uey.3 uc008uey.4 
ENSMUST00000058787.9 Glra2 ENSMUST00000058787.9 glycine receptor, alpha 2 subunit, transcript variant 1 (from RefSeq NM_183427.5) ENSMUST00000058787.1 ENSMUST00000058787.2 ENSMUST00000058787.3 ENSMUST00000058787.4 ENSMUST00000058787.5 ENSMUST00000058787.6 ENSMUST00000058787.7 ENSMUST00000058787.8 GLRA2_MOUSE Glra2 NM_183427 Q7TNC8 uc009uwb.1 uc009uwb.2 uc009uwb.3 Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in synaptic plasticity (PubMed:26370147). Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down- regulation of neuronal excitability. Plays a role in cellular responses to ethanol. Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; Homopentamer (in vitro). Interacts with GLRB. Heteropentamer composed of GLRA2 and GLRB. Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different. Postsynaptic cell membrane ; Multi-pass membrane protein Synapse Cell membrane; Multi-pass membrane protein Cell projection Detected in the retina inner plexiform layer (at protein level) (PubMed:15329889). Detected in neonate retina. Detected in brain (PubMed:21924294). Detected in spinal cord, with higher levels in the dorsal horn (PubMed:16847326, PubMed:21924294). Loss of glycine-induced currents in cortical neurons from 17 dpc embryos. Still, mutant mice are born at the expected Mendelian rate, are healthy and fertile. No effect on glycine- induced currents in cortical neurons from seven day old mice (PubMed:16847326). Baseline nociception is not changed, but mutant mice show increased hyperalgesia in response to mechanical stimuli during later stages of inflammation caused by zymosan injection (PubMed:21924294). Knockout mice show impaired learnig, short- and long-term memory deficits, and impaired long-term potentiation in the prefrontal cortex. Locomotor activity, motor coordination, and social behavior are normal (PubMed:26370147). The alpha subunit binds strychnine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2 sub-subfamily. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction neuropeptide signaling pathway chemical synaptic transmission membrane integral component of membrane glycine binding extracellular-glycine-gated chloride channel activity transmitter-gated ion channel activity glycine-gated chloride ion channel activity cell junction ion transmembrane transport chloride channel complex regulation of membrane potential cell projection neuron projection response to amino acid synapse postsynaptic membrane metal ion binding neurological system process synaptic transmission, glycinergic regulation of postsynaptic membrane potential excitatory postsynaptic potential cellular response to amino acid stimulus cellular response to zinc ion cellular response to ethanol chloride transmembrane transport transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc009uwb.1 uc009uwb.2 uc009uwb.3 
ENSMUST00000058790.12 Ldlrad3 ENSMUST00000058790.12 low density lipoprotein receptor class A domain containing 3, transcript variant 1 (from RefSeq NM_178886.3) B2RR20 B2RR20_MOUSE ENSMUST00000058790.1 ENSMUST00000058790.10 ENSMUST00000058790.11 ENSMUST00000058790.2 ENSMUST00000058790.3 ENSMUST00000058790.4 ENSMUST00000058790.5 ENSMUST00000058790.6 ENSMUST00000058790.7 ENSMUST00000058790.8 ENSMUST00000058790.9 Ldlrad3 NM_178886 uc008lhr.1 uc008lhr.2 uc008lhr.3 uc008lhr.4 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc008lhr.1 uc008lhr.2 uc008lhr.3 uc008lhr.4 
ENSMUST00000058793.14 Poldip3 ENSMUST00000058793.14 polymerase (DNA-directed), delta interacting protein 3, transcript variant 1 (from RefSeq NM_178627.4) B2FDB4 ENSMUST00000058793.1 ENSMUST00000058793.10 ENSMUST00000058793.11 ENSMUST00000058793.12 ENSMUST00000058793.13 ENSMUST00000058793.2 ENSMUST00000058793.3 ENSMUST00000058793.4 ENSMUST00000058793.5 ENSMUST00000058793.6 ENSMUST00000058793.7 ENSMUST00000058793.8 ENSMUST00000058793.9 NM_178627 PDIP3_MOUSE Q6PE83 Q80X99 Q8BG81 Q8CI28 uc007wzz.1 uc007wzz.2 uc007wzz.3 Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex (By similarity). Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. Interacts with THOC2, DDX39B and ZC3H11A; the interactions are ATP-dependent and indicative for an association with the TREX complex (By similarity). Nucleus Nucleus speckle Cytoplasm Note=Nucleocytoplasmic shuttling protein. nucleic acid binding RNA binding nucleus cytoplasm regulation of translation nuclear speck poly(A)+ mRNA export from nucleus cytoplasmic ribonucleoprotein granule macromolecular complex binding positive regulation of translation mRNA transport uc007wzz.1 uc007wzz.2 uc007wzz.3 
ENSMUST00000058796.7 Kdm4d ENSMUST00000058796.7 lysine (K)-specific demethylase 4D, transcript variant 1 (from RefSeq NM_173433.3) A2CGB5 B8JK34 ENSMUST00000058796.1 ENSMUST00000058796.2 ENSMUST00000058796.3 ENSMUST00000058796.4 ENSMUST00000058796.5 ENSMUST00000058796.6 Jhdm3d Jmjd2d KDM4D_MOUSE NM_173433 Q2M1G7 Q3U2K5 Q8BI19 uc009oen.1 uc009oen.2 uc009oen.3 Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys- 20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)- [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60200, Rhea:RHEA- COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961; EC=1.14.11.66; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Nucleus Ubiquitinated via 'Lys-63'-linked ubiquitin chains. Deubiquitinated by USP14 with the help of TRIM14 leading to stabilization. Belongs to the JHDM3 histone demethylase family. Sequence=BAC26740.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC26740.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAE33135.1; Type=Frameshift; Evidence=; double-strand break repair via homologous recombination regulation of protein phosphorylation damaged DNA binding nucleus pericentric heterochromatin chromatin organization chromatin remodeling cellular response to DNA damage stimulus oxidoreductase activity chromatin DNA binding histone demethylase activity histone demethylase activity (H3-K9 specific) histone H3-K9 demethylation histone methyltransferase complex positive regulation of chromatin binding site of double-strand break metal ion binding dioxygenase activity oxidation-reduction process cellular response to ionizing radiation negative regulation of histone H3-K9 trimethylation positive regulation of double-strand break repair via nonhomologous end joining uc009oen.1 uc009oen.2 uc009oen.3 
ENSMUST00000058814.7 Rab9b ENSMUST00000058814.7 RAB9B, member RAS oncogene family (from RefSeq NM_176971.3) ENSMUST00000058814.1 ENSMUST00000058814.2 ENSMUST00000058814.3 ENSMUST00000058814.4 ENSMUST00000058814.5 ENSMUST00000058814.6 NM_176971 Q8BHH2 RAB9B_MOUSE uc009uje.1 uc009uje.2 uc009uje.3 Involved in the transport of proteins between the endosomes and the trans Golgi network. Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:25220469). The GTP-bound form but not the GDP-bound form interacts with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (By similarity). Q8BHH2; Q8BHH2: Rab9b; NbExp=2; IntAct=EBI-11568845, EBI-11568845; Q8BHH2; Q8BPQ7-1: Sgsm1; NbExp=3; IntAct=EBI-11568845, EBI-16121756; Cell membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side Note=Recruited to phagosomes containing S.aureus or Mycobacterium. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity protein binding GTP binding lysosome late endosome cytosol plasma membrane intracellular protein transport protein transport membrane GDP binding phagocytic vesicle membrane cytoplasmic vesicle Rab protein signal transduction retrograde transport, endosome to Golgi identical protein binding phagocytic vesicle uc009uje.1 uc009uje.2 uc009uje.3 
ENSMUST00000058825.5 Ccdc121rt1 ENSMUST00000058825.5 coiled-coil domain containing 121, retrogene 1 (from RefSeq NM_207280.3) Ccdc121rt1 E9Q6D3 E9Q6D3_MOUSE ENSMUST00000058825.1 ENSMUST00000058825.2 ENSMUST00000058825.3 ENSMUST00000058825.4 NM_207280 uc011wxt.1 uc011wxt.2 molecular_function cellular_component biological_process uc011wxt.1 uc011wxt.2 
ENSMUST00000058829.4 Neto1 ENSMUST00000058829.4 neuropilin (NRP) and tolloid (TLL)-like 1, transcript variant 1 (from RefSeq NM_144946.5) Btcl1 ENSMUST00000058829.1 ENSMUST00000058829.2 ENSMUST00000058829.3 NETO1_MOUSE NM_144946 Q80X39 Q8C4S3 Q8CCM2 Q8R4I7 uc008fuz.1 uc008fuz.2 uc008fuz.3 uc008fuz.4 Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A- containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory. Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C- terminal TRV domain. Interacts with GRIN2A and GRIN2B via its CUB domains. Q8R4I7; Q62108: Dlg4; NbExp=7; IntAct=EBI-2314926, EBI-300895; Q8R4I7; P78352: DLG4; Xeno; NbExp=2; IntAct=EBI-2314926, EBI-80389; Q8R4I7; Q00959: Grin2a; Xeno; NbExp=4; IntAct=EBI-2314926, EBI-630970; Q8R4I7; Q00960: Grin2b; Xeno; NbExp=2; IntAct=EBI-2314926, EBI-396905; Membrane ; Single-pass type I membrane protein Postsynaptic density membrane Note=Component of the postsynaptic density (PSD) of excitatory synapses. Expressed only in brain. Present throughout the central nervous system. Highly expressed in the hippocampal CA3 region, olfactory bulb and tubercle, caudate putamen, and neocortex in the adult brain. Observed restrictively in brain throughout embryonic and postnatal stages. Expression pattern in brain slightly changes from 13 dpc to postnatal day 21 (P21). Expressed in both cerebrum and cerebellum throughout P0 to P35. In the cerebrum expression reached a plateau at P14 while expression in the cerebellum remains constant throughout all postnatal stages. Depressed long-term potentiation (LTP) at Schaffer collateral-CA1 synapses, NMDAR-dependent spatial learning and memory. Rescued by the ampakine CX546 at physiological doses. protein binding plasma membrane memory visual learning postsynaptic density membrane integral component of membrane cell junction ionotropic glutamate receptor binding synapse postsynaptic membrane regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity excitatory synapse receptor localization to synapse postsynaptic density membrane glutamatergic synapse integral component of postsynaptic density membrane regulation of kainate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential uc008fuz.1 uc008fuz.2 uc008fuz.3 uc008fuz.4 
ENSMUST00000058839.10 Klhl6 ENSMUST00000058839.10 kelch-like 6, transcript variant 7 (from RefSeq NR_184432.1) ENSMUST00000058839.1 ENSMUST00000058839.2 ENSMUST00000058839.3 ENSMUST00000058839.4 ENSMUST00000058839.5 ENSMUST00000058839.6 ENSMUST00000058839.7 ENSMUST00000058839.8 ENSMUST00000058839.9 KLHL6_MOUSE NR_184432 Q497G3 Q6V595 uc007ypg.1 uc007ypg.2 uc007ypg.3 uc007ypg.4 Involved in B-lymphocyte antigen receptor signaling and germinal center formation. Expressed in embryonic blood vessel endothelial cells but not in the vasculature of adult organs. In adults, detected at high levels in hematopoietic and lymphoid organs. Up-regulated during germinal center formation. Mice show impaired antigen-dependent germinal center formation and B-cell antigen receptor (BCR) signaling. The number of mature B-cells is reduced. Sequence=AAI00569.1; Type=Erroneous initiation; Evidence=; germinal center formation response to bacterium B cell receptor signaling pathway uc007ypg.1 uc007ypg.2 uc007ypg.3 uc007ypg.4 
ENSMUST00000058844.6 Zfp786 ENSMUST00000058844.6 zinc finger protein 786 (from RefSeq NM_177882.4) ENSMUST00000058844.1 ENSMUST00000058844.2 ENSMUST00000058844.3 ENSMUST00000058844.4 ENSMUST00000058844.5 NM_177882 Q8BV42 ZN786_MOUSE Znf786 uc009btg.1 uc009btg.2 uc009btg.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated biological_process metal ion binding uc009btg.1 uc009btg.2 uc009btg.3 
ENSMUST00000058845.9 Basp1 ENSMUST00000058845.9 brain abundant, membrane attached signal protein 1 (from RefSeq NM_027395.2) BASP1_MOUSE ENSMUST00000058845.1 ENSMUST00000058845.2 ENSMUST00000058845.3 ENSMUST00000058845.4 ENSMUST00000058845.5 ENSMUST00000058845.6 ENSMUST00000058845.7 ENSMUST00000058845.8 NM_027395 Nap22 Q91XV3 uc007vix.1 uc007vix.2 uc007vix.3 Cell membrane; Lipid-anchor. Cell projection, growth cone. Note=Associated with the membranes of growth cones that form the tips of elongating axons. Belongs to the BASP1 family. transcription corepressor activity protein binding nucleus cytoplasm plasma membrane COP9 signalosome membrane nuclear speck protein domain specific binding cell junction growth cone cell projection transcription regulatory region DNA binding negative regulation of transcription, DNA-templated glomerular visceral epithelial cell differentiation uc007vix.1 uc007vix.2 uc007vix.3 
ENSMUST00000058846.11 Ripply2 ENSMUST00000058846.11 ripply transcriptional repressor 2, transcript variant 4 (from RefSeq NM_001379244.1) ENSMUST00000058846.1 ENSMUST00000058846.10 ENSMUST00000058846.2 ENSMUST00000058846.3 ENSMUST00000058846.4 ENSMUST00000058846.5 ENSMUST00000058846.6 ENSMUST00000058846.7 ENSMUST00000058846.8 ENSMUST00000058846.9 NM_001379244 Q2WG76 Q8BNN5 RIPP2_MOUSE Ripply2 uc009qya.1 uc009qya.2 uc009qya.3 Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites. Nucleus Expressed in the embryonic anterior presomitic mesoderm. First expressed in S-I at 8.5 dpc, where expression is maintained until 13.5 dpc, with an additional stripe of expression sometimes seen in the rostral part of S0 and S-I. By MESP2, and acts in a negative feedback loop with MESP2, functioning negatively toward MESP2 to regulate NOTCH signaling in the anterior presomitic mesoderm. The ripply homology domain is required for transcriptional repression. The WRPW motif is required for binding to tle/groucho proteins. Belongs to the ripply family. Sequence=BAC38162.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; negative regulation of transcription from RNA polymerase II promoter ossification somitogenesis nucleus Notch signaling pathway multicellular organism development determination of left/right symmetry axis specification embryonic pattern specification regulation of gene expression somite rostral/caudal axis specification post-anal tail morphogenesis bone morphogenesis uc009qya.1 uc009qya.2 uc009qya.3 
ENSMUST00000058856.9 Scd4 ENSMUST00000058856.9 stearoyl-coenzyme A desaturase 4 (from RefSeq NM_183216.3) B9EIY5 ENSMUST00000058856.1 ENSMUST00000058856.2 ENSMUST00000058856.3 ENSMUST00000058856.4 ENSMUST00000058856.5 ENSMUST00000058856.6 ENSMUST00000058856.7 ENSMUST00000058856.8 NM_183216 Q6T707 SCD4_MOUSE Scd4 uc008hpq.1 uc008hpq.2 uc008hpq.3 Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:12815040, PubMed:16443825). Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:19721, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57387, ChEBI:CHEBI:57394; EC=1.14.19.1; Evidence=; Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:36931, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57379, ChEBI:CHEBI:61540; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Expected to bind 2 Fe(2+) ions per subunit. ; Endoplasmic reticulum membrane ; Multi-pass membrane protein Microsome membrane Detected in heart, but not in brain, liver, skin or adipose tissue. Up-regulated by agonists that activate NR1H3. Up-regulated by a fat-free high-carbohydrate diet. Not down-regulated by a high- carbohydrate diet supplemented with unsaturated fatty acids. Down- regulated by leptin. The histidine box domains are involved in binding the catalytic metal ions. Belongs to the fatty acid desaturase type 1 family. stearoyl-CoA 9-desaturase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water integral component of endoplasmic reticulum membrane organelle membrane cellular response to nutrient palmitoyl-CoA 9-desaturase activity intracellular membrane-bounded organelle metal ion binding oxidation-reduction process response to fatty acid monounsaturated fatty acid biosynthetic process uc008hpq.1 uc008hpq.2 uc008hpq.3 
ENSMUST00000058860.14 Usf2 ENSMUST00000058860.14 upstream transcription factor 2, transcript variant 7 (from RefSeq NR_185329.1) ENSMUST00000058860.1 ENSMUST00000058860.10 ENSMUST00000058860.11 ENSMUST00000058860.12 ENSMUST00000058860.13 ENSMUST00000058860.2 ENSMUST00000058860.3 ENSMUST00000058860.4 ENSMUST00000058860.5 ENSMUST00000058860.6 ENSMUST00000058860.7 ENSMUST00000058860.8 ENSMUST00000058860.9 NR_185329 Q3UIL2 Q64705 Q8VE59 USF2_MOUSE uc009ghh.1 uc009ghh.2 uc009ghh.3 Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2). Interacts with MAF. Q64705; P42225: Stat1; NbExp=3; IntAct=EBI-647583, EBI-647118; Nucleus. Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=USF2A; IsoId=Q64705-1; Sequence=Displayed; Name=USF2B; IsoId=Q64705-2; Sequence=VSP_002166; Sequence=AAA20493.1; Type=Erroneous initiation; Evidence=; Sequence=AAH19729.1; Type=Erroneous initiation; Evidence=; positive regulation of transcription from RNA polymerase II promoter by glucose RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter lactation protein homodimerization activity intracellular membrane-bounded organelle bHLH transcription factor binding sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity lipid homeostasis uc009ghh.1 uc009ghh.2 uc009ghh.3 
ENSMUST00000058865.14 Pdzk1 ENSMUST00000058865.14 PDZ domain containing 1, transcript variant 1 (from RefSeq NM_021517.3) A0A0R4J1V0 A0A0R4J1V0_MOUSE ENSMUST00000058865.1 ENSMUST00000058865.10 ENSMUST00000058865.11 ENSMUST00000058865.12 ENSMUST00000058865.13 ENSMUST00000058865.2 ENSMUST00000058865.3 ENSMUST00000058865.4 ENSMUST00000058865.5 ENSMUST00000058865.6 ENSMUST00000058865.7 ENSMUST00000058865.8 ENSMUST00000058865.9 NM_021517 Pdzk1 uc008qoi.1 uc008qoi.2 uc008qoi.3 uc008qoi.4 Belongs to the NHER family. scavenger receptor binding carnitine transport apical plasma membrane PDZ domain binding microvillus membrane positive regulation of ion transmembrane transporter activity macromolecular complex binding membrane raft positive regulation of cation transmembrane transport uc008qoi.1 uc008qoi.2 uc008qoi.3 uc008qoi.4 
ENSMUST00000058866.8 Nxph3 ENSMUST00000058866.8 neurexophilin 3 (from RefSeq NM_130858.4) ENSMUST00000058866.1 ENSMUST00000058866.2 ENSMUST00000058866.3 ENSMUST00000058866.4 ENSMUST00000058866.5 ENSMUST00000058866.6 ENSMUST00000058866.7 NM_130858 NXPH3_MOUSE Q91VX5 uc007lal.1 uc007lal.2 uc007lal.3 May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins. Secreted Highest level in brain, present also in lung, kidney and testis. May be proteolytically processed at the boundary between the N- terminal non-conserved and the central conserved domain in neuron-like cells. Belongs to the neurexophilin family. receptor binding extracellular region uc007lal.1 uc007lal.2 uc007lal.3 
ENSMUST00000058868.9 Matcap2 ENSMUST00000058868.9 microtubule associated tyrosine carboxypeptidase 2, transcript variant 1 (from RefSeq NM_026739.3) ENSMUST00000058868.1 ENSMUST00000058868.2 ENSMUST00000058868.3 ENSMUST00000058868.4 ENSMUST00000058868.5 ENSMUST00000058868.6 ENSMUST00000058868.7 ENSMUST00000058868.8 Kiaa0895 MACA2_MOUSE Matcap2 NM_026739 Q5DU11 Q7TQE7 Q80V66 Q9CTJ2 uc009oom.1 uc009oom.2 uc009oom.3 uc009oom.4 Putative tyrosine carboxypeptidase. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TQE7-1; Sequence=Displayed; Name=2; IsoId=Q7TQE7-2; Sequence=VSP_031688; Putative metalloprotease with an atypical HExxxH zinc-binding motif instead of HExxH, which interrupts the active site-containing helix without affecting the integrity of the catalytic site arrangement. Sequence=BAD90420.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc009oom.1 uc009oom.2 uc009oom.3 uc009oom.4 
ENSMUST00000058879.8 Ntf5 ENSMUST00000058879.8 neurotrophin 5 (from RefSeq NM_198190.1) ENSMUST00000058879.1 ENSMUST00000058879.2 ENSMUST00000058879.3 ENSMUST00000058879.4 ENSMUST00000058879.5 ENSMUST00000058879.6 ENSMUST00000058879.7 NM_198190 NTF4_MOUSE Ntf4 Q80VU4 uc009gva.1 uc009gva.2 This gene encodes a secreted protein belonging to the neurotrophin family of structurally related molecules that play a crucial role in the control of neuronal numbers and of dendritic growth. The encoded preproprotein undergoes post-translational processing to generate non-covalently associated homodimeric functional protein. Mice deficient in the encoded protein exhibit a loss of sensory neurons in the nodose-petrosal and geniculate ganglia, have deficits in long-term memory and hippocampal long-lasting long-term potentiation. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052191.1, BU510565.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Could serve as a target-derived trophic factor for sensory and sympathetic neurons. Secreted Belongs to the NGF-beta family. receptor binding neurotrophin p75 receptor binding extracellular region extracellular space endoplasmic reticulum lumen transmembrane receptor protein tyrosine kinase signaling pathway ganglion mother cell fate determination peripheral nervous system development memory long-term memory synaptic vesicle sensory organ boundary specification growth factor activity adult locomotory behavior epidermis development nerve development axon dendrite cytoplasmic vesicle nerve growth factor signaling pathway mechanoreceptor differentiation negative regulation of neuron apoptotic process regulation of neuron differentiation neuron projection morphogenesis modulation of synaptic transmission innervation negative regulation of cell death taste bud development uc009gva.1 uc009gva.2 
ENSMUST00000058884.10 Parn ENSMUST00000058884.10 poly(A)-specific ribonuclease (deadenylation nuclease), transcript variant 1 (from RefSeq NM_028761.3) A0A0R4J0P6 A0A0R4J0P6_MOUSE ENSMUST00000058884.1 ENSMUST00000058884.2 ENSMUST00000058884.3 ENSMUST00000058884.4 ENSMUST00000058884.5 ENSMUST00000058884.6 ENSMUST00000058884.7 ENSMUST00000058884.8 ENSMUST00000058884.9 NM_028761 Parn uc007ygc.1 uc007ygc.2 uc007ygc.3 Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence=; Cytoplasm Nucleus Belongs to the CAF1 family. box H/ACA snoRNA 3'-end processing nucleic acid binding RNA binding poly(A)-specific ribonuclease activity nucleus nucleolus cytoplasm mRNA catabolic process miRNA catabolic process protein kinase binding positive regulation of telomere maintenance via telomerase cation binding metal ion binding positive regulation of telomerase activity polyadenylation-dependent snoRNA 3'-end processing RNA phosphodiester bond hydrolysis, exonucleolytic telomerase RNA stabilization regulation of telomerase RNA localization to Cajal body uc007ygc.1 uc007ygc.2 uc007ygc.3 
ENSMUST00000058889.5 Fancm ENSMUST00000058889.5 Fanconi anemia, complementation group M, transcript variant 1 (from RefSeq NM_178912.4) ENSMUST00000058889.1 ENSMUST00000058889.2 ENSMUST00000058889.3 ENSMUST00000058889.4 FANCM_MOUSE Kiaa1596 NM_178912 Q69ZF5 Q8BGE5 Q8BKB7 Q8BUA8 uc007nrf.1 uc007nrf.2 DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Component of the Fanconi anemia (FA) core complex, which consists of CENPS, CENPX, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FAAP24 and FAAP100. The FA core complex associates with Bloom syndrome (BLM) complex, which consists of at least BLM, DNA topoisomerase 3-alpha/TOP3A, RMI1/BLAP75, RPA1/RPA70 and RPA2/RPA32. This supercomplex between FA and BLM complexes has been called BRAFT. Forms a discrete complex with CENPS and CENPX, called FANCM-MHF; this interaction stimulates DNA binding and replication fork remodeling by FANCM and stabilizes the binding partners. Forms a heterodimer with FAAP24; this interaction increases FANCM single-stranded DNA-binding activity. Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BGE5-1; Sequence=Displayed; Name=2; IsoId=Q8BGE5-2; Sequence=VSP_015994, VSP_015995; Name=3; IsoId=Q8BGE5-3; Sequence=VSP_015992, VSP_015993; Name=4; IsoId=Q8BGE5-4; Sequence=VSP_015991; Phosphorylated; hyperphosphorylated in response to genotoxic stress. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. Sequence=BAD32489.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding resolution of meiotic recombination intermediates DNA binding chromatin binding RNA helicase activity helicase activity nuclease activity ATP binding nucleus nucleoplasm DNA repair cellular response to DNA damage stimulus hydrolase activity replication fork processing Fanconi anaemia nuclear complex FANCM-MHF complex nucleic acid phosphodiester bond hydrolysis positive regulation of protein monoubiquitination uc007nrf.1 uc007nrf.2 
ENSMUST00000058897.11 Pilra ENSMUST00000058897.11 paired immunoglobin-like type 2 receptor alpha (from RefSeq NM_153510.3) ENSMUST00000058897.1 ENSMUST00000058897.10 ENSMUST00000058897.2 ENSMUST00000058897.3 ENSMUST00000058897.4 ENSMUST00000058897.5 ENSMUST00000058897.6 ENSMUST00000058897.7 ENSMUST00000058897.8 ENSMUST00000058897.9 NM_153510 PILRA_MOUSE Q2YFS3 Q8BYA6 uc009aea.1 uc009aea.2 uc009aea.3 uc009aea.4 Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. Receptor for CD99 and PIANP. Interacts with CD99. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2YFS3-1; Sequence=Displayed; Name=2; IsoId=Q2YFS3-2; Sequence=VSP_017505; Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. PTPN6 seems to bind predominantly to the first ITIM motif (By similarity). Phosphorylated on tyrosine residues. protein binding signal transduction membrane integral component of membrane MHC class I protein binding uc009aea.1 uc009aea.2 uc009aea.3 uc009aea.4 
ENSMUST00000058899.13 Nr1h5 ENSMUST00000058899.13 nuclear receptor subfamily 1, group H, member 5, transcript variant 1 (from RefSeq NM_198658.2) E9Q5A6 E9Q5A6_MOUSE ENSMUST00000058899.1 ENSMUST00000058899.10 ENSMUST00000058899.11 ENSMUST00000058899.12 ENSMUST00000058899.2 ENSMUST00000058899.3 ENSMUST00000058899.4 ENSMUST00000058899.5 ENSMUST00000058899.6 ENSMUST00000058899.7 ENSMUST00000058899.8 ENSMUST00000058899.9 NM_198658 Nr1h5 uc008qse.1 uc008qse.2 Nucleus Belongs to the nuclear hormone receptor family. NR1 subfamily. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity nucleus regulation of transcription, DNA-templated lipid metabolic process multicellular organism development transcription factor binding zinc ion binding cell differentiation ligand-dependent nuclear receptor transcription coactivator activity signaling receptor activity cholesterol homeostasis steroid hormone mediated signaling pathway sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding lipid homeostasis cellular response to lipopolysaccharide RNA polymerase II transcription factor complex uc008qse.1 uc008qse.2 
ENSMUST00000058902.6 Eml6 ENSMUST00000058902.6 echinoderm microtubule associated protein like 6 (from RefSeq NM_146016.2) EMAL6_MOUSE ENSMUST00000058902.1 ENSMUST00000058902.2 ENSMUST00000058902.3 ENSMUST00000058902.4 ENSMUST00000058902.5 Eml5l NM_146016 Q5SQM0 Q8C4R3 Q8C7L3 Q8R1E3 uc007ihq.1 uc007ihq.2 uc007ihq.3 May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. Cytoplasm, cytoskeleton Belongs to the WD repeat EMAP family. Sequence=AAH24726.1; Type=Erroneous initiation; Evidence=; Sequence=BAC38214.1; Type=Erroneous initiation; Evidence=; cytoplasm cytoskeleton microtubule microtubule binding biological_process uc007ihq.1 uc007ihq.2 uc007ihq.3 
ENSMUST00000058905.8 Pars2 ENSMUST00000058905.8 prolyl-tRNA synthetase (mitochondrial)(putative), transcript variant 1 (from RefSeq NM_172272.2) A2AVQ8 ENSMUST00000058905.1 ENSMUST00000058905.2 ENSMUST00000058905.3 ENSMUST00000058905.4 ENSMUST00000058905.5 ENSMUST00000058905.6 ENSMUST00000058905.7 NM_172272 Q8CFI5 Q8R0C4 SYPM_MOUSE uc008typ.1 uc008typ.2 uc008typ.3 Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the proline amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis. The reaction occurs in a two steps: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Reaction=ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl- tRNA(Pro); Xref=Rhea:RHEA:14305, Rhea:RHEA-COMP:9700, Rhea:RHEA- COMP:9702, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:60039, ChEBI:CHEBI:78442, ChEBI:CHEBI:78532, ChEBI:CHEBI:456215; EC=6.1.1.15; Evidence=; Mitochondrion matrix Belongs to the class-II aminoacyl-tRNA synthetase family. nucleotide binding aminoacyl-tRNA ligase activity proline-tRNA ligase activity ATP binding cytoplasm mitochondrion mitochondrial matrix translation tRNA aminoacylation for protein translation prolyl-tRNA aminoacylation ligase activity uc008typ.1 uc008typ.2 uc008typ.3 
ENSMUST00000058912.3 Lcn10 ENSMUST00000058912.3 lipocalin 10 (from RefSeq NM_178036.4) ENSMUST00000058912.1 ENSMUST00000058912.2 LCN10_MOUSE NM_178036 Q810Z1 uc008ite.1 uc008ite.2 uc008ite.3 uc008ite.4 May play a role in male fertility. May act as a retinoid carrier protein within the epididymis. Secreted Expressed in epididymis. Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component extracellular region biological_process small molecule binding uc008ite.1 uc008ite.2 uc008ite.3 uc008ite.4 
ENSMUST00000058914.10 Tuba1c ENSMUST00000058914.10 tubulin, alpha 1C (from RefSeq NM_009448.4) ENSMUST00000058914.1 ENSMUST00000058914.2 ENSMUST00000058914.3 ENSMUST00000058914.4 ENSMUST00000058914.5 ENSMUST00000058914.6 ENSMUST00000058914.7 ENSMUST00000058914.8 ENSMUST00000058914.9 NM_009448 Q52L87 Q52L87_MOUSE Tuba1c Tuba6 uc007xom.1 uc007xom.2 uc007xom.3 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Cytoplasm, cytoskeleton Belongs to the tubulin family. nucleotide binding GTPase activity structural constituent of cytoskeleton GTP binding cytoplasm cytoskeleton microtubule cytoskeleton organization microtubule-based process microtubule cytoskeleton uc007xom.1 uc007xom.2 uc007xom.3 
ENSMUST00000058918.5 Gm7461 ENSMUST00000058918.5 Gm7461 (from geneSymbol) AK076970 ENSMUST00000058918.1 ENSMUST00000058918.2 ENSMUST00000058918.3 ENSMUST00000058918.4 uc291xym.1 uc291xym.2 uc291xym.1 uc291xym.2 
ENSMUST00000058943.8 Ankrd34a ENSMUST00000058943.8 ankyrin repeat domain 34A, transcript variant 2 (from RefSeq NM_001411495.1) Ankrd34a B2RW11 B2RW11_MOUSE ENSMUST00000058943.1 ENSMUST00000058943.2 ENSMUST00000058943.3 ENSMUST00000058943.4 ENSMUST00000058943.5 ENSMUST00000058943.6 ENSMUST00000058943.7 NM_001411495 uc008qng.1 uc008qng.2 uc008qng.3 Belongs to the ANKRD34 family. molecular_function biological_process uc008qng.1 uc008qng.2 uc008qng.3 
ENSMUST00000058955.5 Spag11a ENSMUST00000058955.5 sperm associated antigen 11A (from RefSeq NM_153115.1) Bin1b ENSMUST00000058955.1 ENSMUST00000058955.2 ENSMUST00000058955.3 ENSMUST00000058955.4 Ep2 Ep2e NM_153115 Q2HPE4 Q30KM3 Q8K4N2 SG11A_MOUSE Spag11 Spag11a uc009lag.1 uc009lag.2 uc009lag.3 Has antimicrobial activity against E.coli (By similarity). Plays a role in the defense response in the male reproductive tract, contributing to sperm maturation, storage and protection (By similarity). Secreted Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Ep2q; IsoId=Q8K4N2-1; Sequence=Displayed; Name=2; IsoId=Q8K4N2-2; Sequence=VSP_020138; Belongs to the beta-defensin family. acrosomal vesicle molecular_function extracellular region defense response defense response to bacterium uc009lag.1 uc009lag.2 uc009lag.3 
ENSMUST00000058978.9 Nqo2 ENSMUST00000058978.9 N-ribosyldihydronicotinamide quinone reductase 2, transcript variant 18 (from RefSeq NM_001426178.1) ENSMUST00000058978.1 ENSMUST00000058978.2 ENSMUST00000058978.3 ENSMUST00000058978.4 ENSMUST00000058978.5 ENSMUST00000058978.6 ENSMUST00000058978.7 ENSMUST00000058978.8 NM_001426178 NQO2_MOUSE Nmor2 Q9JI75 uc007qat.1 uc007qat.2 uc007qat.3 uc007qat.4 The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. Reaction=1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside; Xref=Rhea:RHEA:12364, ChEBI:CHEBI:15378, ChEBI:CHEBI:15927, ChEBI:CHEBI:24646, ChEBI:CHEBI:55458, ChEBI:CHEBI:132124; EC=1.10.5.1; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Homodimer. Cytoplasm Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor. Belongs to the NAD(P)H dehydrogenase (quinone) family. dihydronicotinamide riboside quinone reductase activity NAD(P)H dehydrogenase (quinone) activity nucleoplasm cytoplasm cytosol memory zinc ion binding electron carrier activity oxidoreductase activity oxidoreductase activity, acting on other nitrogenous compounds as donors electron transport chain chloride ion binding protein homodimerization activity positive regulation of neuron apoptotic process metal ion binding oxidation-reduction process positive regulation of ERK1 and ERK2 cascade FAD binding melatonin binding positive regulation of vascular smooth muscle cell proliferation resveratrol binding positive regulation of reactive oxygen species metabolic process uc007qat.1 uc007qat.2 uc007qat.3 uc007qat.4 
ENSMUST00000058981.3 Lxn ENSMUST00000058981.3 latexin (from RefSeq NM_016753.4) ENSMUST00000058981.1 ENSMUST00000058981.2 Lxn NM_016753 Q14BZ3 Q14BZ3_MOUSE uc008pln.1 uc008pln.2 uc008pln.3 Belongs to the protease inhibitor I47 (latexin) family. uc008pln.1 uc008pln.2 uc008pln.3 
ENSMUST00000058987.5 Krtap4-2 ENSMUST00000058987.5 keratin associated protein 4-2 (from RefSeq NM_026807.2) B1AQ85 B1AQ85_MOUSE ENSMUST00000058987.1 ENSMUST00000058987.2 ENSMUST00000058987.3 ENSMUST00000058987.4 Krtap4-2 NM_026807 uc007lji.1 uc007lji.2 uc007lji.3 cellular_component intermediate filament biological_process keratin filament uc007lji.1 uc007lji.2 uc007lji.3 
ENSMUST00000058991.5 Or7a36 ENSMUST00000058991.5 olfactory receptor family 7 subfamily A member 36 (from RefSeq NM_147071.2) ENSMUST00000058991.1 ENSMUST00000058991.2 ENSMUST00000058991.3 ENSMUST00000058991.4 NM_147071 Olfr1352 Or7a36 Q8VGX5 Q8VGX5_MOUSE uc007fyl.1 uc007fyl.2 uc007fyl.3 uc007fyl.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DR065534.1, DR065881.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007fyl.1 uc007fyl.2 uc007fyl.3 uc007fyl.4 
ENSMUST00000058994.6 Tram1l1 ENSMUST00000058994.6 translocation associated membrane protein 1-like 1 (from RefSeq NM_146140.4) ENSMUST00000058994.1 ENSMUST00000058994.2 ENSMUST00000058994.3 ENSMUST00000058994.4 ENSMUST00000058994.5 NM_146140 Q8C455 Q8C6X6 Q8QZR0 TR1L1_MOUSE uc008rfr.1 uc008rfr.2 uc008rfr.3 Stimulatory or required for the translocation of secretory proteins across the ER membrane. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the TRAM family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane rough endoplasmic reticulum SRP-dependent cotranslational protein targeting to membrane, translocation protein transport membrane integral component of membrane uc008rfr.1 uc008rfr.2 uc008rfr.3 
ENSMUST00000058997.15 Zbtb7c ENSMUST00000058997.15 zinc finger and BTB domain containing 7C, transcript variant 1 (from RefSeq NM_145356.3) ENSMUST00000058997.1 ENSMUST00000058997.10 ENSMUST00000058997.11 ENSMUST00000058997.12 ENSMUST00000058997.13 ENSMUST00000058997.14 ENSMUST00000058997.2 ENSMUST00000058997.3 ENSMUST00000058997.4 ENSMUST00000058997.5 ENSMUST00000058997.6 ENSMUST00000058997.7 ENSMUST00000058997.8 ENSMUST00000058997.9 NM_145356 Q8VCZ7 ZBT7C_MOUSE Zbtb36 uc008fqi.1 uc008fqi.2 uc008fqi.3 uc008fqi.4 May be a tumor suppressor gene. nucleic acid binding protein binding nucleus negative regulation of cell proliferation positive regulation of fat cell differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding regulation of RNA polymerase II regulatory region sequence-specific DNA binding uc008fqi.1 uc008fqi.2 uc008fqi.3 uc008fqi.4 
ENSMUST00000059003.5 Hsf3 ENSMUST00000059003.5 heat shock transcription factor 3, transcript variant 1 (from RefSeq NM_001310754.2) E9QNK9 E9QNK9_MOUSE ENSMUST00000059003.1 ENSMUST00000059003.2 ENSMUST00000059003.3 ENSMUST00000059003.4 Hsf3 NM_001310754 uc012hml.1 uc012hml.2 uc012hml.3 uc012hml.4 Nucleus Belongs to the HSF family. DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cellular response to heat sequence-specific DNA binding uc012hml.1 uc012hml.2 uc012hml.3 uc012hml.4 
ENSMUST00000059018.14 Fbxo31 ENSMUST00000059018.14 F-box protein 31, transcript variant 1 (from RefSeq NM_133765.5) ENSMUST00000059018.1 ENSMUST00000059018.10 ENSMUST00000059018.11 ENSMUST00000059018.12 ENSMUST00000059018.13 ENSMUST00000059018.2 ENSMUST00000059018.3 ENSMUST00000059018.4 ENSMUST00000059018.5 ENSMUST00000059018.6 ENSMUST00000059018.7 ENSMUST00000059018.8 ENSMUST00000059018.9 FBX31_MOUSE MNCb-2609 NM_133765 Q3TQF0 Q8K1A7 Q9JJC4 uc009nrv.1 uc009nrv.2 uc009nrv.3 uc009nrv.4 uc009nrv.5 Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity). Protein modification; protein ubiquitination. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Phosphorylation by ATM following gamma-irradiation results in its stabilization. Belongs to the FBXO31 family. Sequence=AAH26929.1; Type=Erroneous initiation; Evidence=; Sequence=BAA95069.1; Type=Erroneous initiation; Evidence=; centrosome cellular response to DNA damage stimulus cell cycle protein ubiquitination SCF ubiquitin ligase complex cyclin binding anaphase-promoting complex-dependent catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process mitotic G1 DNA damage checkpoint neuronal cell body positive regulation of dendrite morphogenesis positive regulation of neuron migration uc009nrv.1 uc009nrv.2 uc009nrv.3 uc009nrv.4 uc009nrv.5 
ENSMUST00000059026.10 Abi3 ENSMUST00000059026.10 ABI family member 3, transcript variant 1 (from RefSeq NM_025659.4) ABI3_MOUSE ENSMUST00000059026.1 ENSMUST00000059026.2 ENSMUST00000059026.3 ENSMUST00000059026.4 ENSMUST00000059026.5 ENSMUST00000059026.6 ENSMUST00000059026.7 ENSMUST00000059026.8 ENSMUST00000059026.9 NM_025659 Nesh Q3TA46 Q6PE63 Q8BYZ1 Q9D7S4 uc007lat.1 uc007lat.2 uc007lat.3 uc007lat.4 Inhibits ectopic tumor cell metastasis of SRD cells. In vitro, reduces cell motility. May interact with PAK1 and PAK2. Probably interacts with TARSH (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BYZ1-1; Sequence=Displayed; Name=2; IsoId=Q8BYZ1-2; Sequence=VSP_010773; Belongs to the ABI family. cytoplasm SH3 domain binding lamellipodium regulation of cell migration identical protein binding peptidyl-tyrosine phosphorylation uc007lat.1 uc007lat.2 uc007lat.3 uc007lat.4 
ENSMUST00000059037.15 Trim12c ENSMUST00000059037.15 tripartite motif-containing 12C, transcript variant 1 (from RefSeq NM_001146007.1) D3Z3L3 D3Z3L3_MOUSE E9Q987 ENSMUST00000059037.1 ENSMUST00000059037.10 ENSMUST00000059037.11 ENSMUST00000059037.12 ENSMUST00000059037.13 ENSMUST00000059037.14 ENSMUST00000059037.2 ENSMUST00000059037.3 ENSMUST00000059037.4 ENSMUST00000059037.5 ENSMUST00000059037.6 ENSMUST00000059037.7 ENSMUST00000059037.8 ENSMUST00000059037.9 NM_001146007 Trim12c uc009iwc.1 uc009iwc.2 uc009iwc.3 uc009iwc.4 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Cytoplasm Nucleus Belongs to the TRIM/RBCC family. P-body pattern recognition receptor signaling pathway ubiquitin-protein transferase activity cytoplasm autophagy zinc ion binding signaling pattern recognition receptor activity protein ubiquitination protein kinase binding protein binding, bridging identical protein binding protein homodimerization activity innate immune response metal ion binding defense response to virus omegasome uc009iwc.1 uc009iwc.2 uc009iwc.3 uc009iwc.4 
ENSMUST00000059045.8 Exosc4 ENSMUST00000059045.8 exosome component 4 (from RefSeq NM_175399.4) ENSMUST00000059045.1 ENSMUST00000059045.2 ENSMUST00000059045.3 ENSMUST00000059045.4 ENSMUST00000059045.5 ENSMUST00000059045.6 ENSMUST00000059045.7 EXOS4_MOUSE NM_175399 Q542B0 Q921I9 Rrp41 uc007wjp.1 uc007wjp.2 uc007wjp.3 Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs (By similarity). Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure (By similarity). Interacts with DDX60 (By similarity). Cytoplasm Nucleus, nucleolus Nucleus Nucleus, nucleoplasm Belongs to the RNase PH family. nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) maturation of 5.8S rRNA nuclear-transcribed mRNA catabolic process RNA binding protein binding nucleus nucleolus cytoplasm cytosol rRNA processing rRNA catabolic process positive regulation of cell growth nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U4 snRNA 3'-end processing transcriptionally active chromatin mRNA 3'-UTR AU-rich region binding DNA deamination intermediate filament cytoskeleton defense response to virus nuclear mRNA surveillance histone mRNA catabolic process polyadenylation-dependent snoRNA 3'-end processing uc007wjp.1 uc007wjp.2 uc007wjp.3 
ENSMUST00000059052.9 Trmt10c ENSMUST00000059052.9 tRNA methyltransferase 10C, mitochondrial RNase P subunit (from RefSeq NM_029092.4) ENSMUST00000059052.1 ENSMUST00000059052.2 ENSMUST00000059052.3 ENSMUST00000059052.4 ENSMUST00000059052.5 ENSMUST00000059052.6 ENSMUST00000059052.7 ENSMUST00000059052.8 Mrpp1 NM_029092 Q3UFY8 Q8R588 Q9DBC1 Rg9mtd1 TM10C_MOUSE Trmt10c uc007zmd.1 uc007zmd.2 uc007zmd.3 Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit. The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme. In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. Reaction=adenosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)- methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43148, Rhea:RHEA-COMP:10363, Rhea:RHEA-COMP:10364, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=2.1.1.218; Evidence=; Reaction=guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)- methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43156, Rhea:RHEA-COMP:10367, Rhea:RHEA-COMP:10368, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.221; Evidence=; Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)- methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:55392, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12415, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; Evidence=; Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3. Interacts with HSD17B10/MRPP2; forming the MRPP1-MRPP2 subcomplex of the mitochondrial ribonuclease P complex. Interacts with GRSF1. Mitochondrion matrix, mitochondrion nucleoid Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family. tRNA binding mitochondrial RNA 5'-end processing nucleus nucleoplasm mitochondrion tRNA processing methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity transferase activity tRNA methylation mitochondrial ribonuclease P complex methylation mitochondrial nucleoid tRNA (guanine(9)-N(1))-methyltransferase activity positive regulation of mitochondrial translation mRNA methylation mitochondrial tRNA processing mitochondrial tRNA 5'-end processing mitochondrial tRNA 3'-end processing uc007zmd.1 uc007zmd.2 uc007zmd.3 
ENSMUST00000059053.11 Lce3d ENSMUST00000059053.11 late cornified envelope 3D (from RefSeq NM_001270426.2) E9Q8V1 E9Q8V1_MOUSE ENSMUST00000059053.1 ENSMUST00000059053.10 ENSMUST00000059053.2 ENSMUST00000059053.3 ENSMUST00000059053.4 ENSMUST00000059053.5 ENSMUST00000059053.6 ENSMUST00000059053.7 ENSMUST00000059053.8 ENSMUST00000059053.9 Gm9782 Lce3d NM_001270426 uc033hwm.1 uc033hwm.2 uc033hwm.3 Belongs to the LCE family. epidermis development uc033hwm.1 uc033hwm.2 uc033hwm.3 
ENSMUST00000059057.14 Fam118b ENSMUST00000059057.14 family with sequence similarity 118, member B, transcript variant 1 (from RefSeq NM_194257.2) ENSMUST00000059057.1 ENSMUST00000059057.10 ENSMUST00000059057.11 ENSMUST00000059057.12 ENSMUST00000059057.13 ENSMUST00000059057.2 ENSMUST00000059057.3 ENSMUST00000059057.4 ENSMUST00000059057.5 ENSMUST00000059057.6 ENSMUST00000059057.7 ENSMUST00000059057.8 ENSMUST00000059057.9 F118B_MOUSE NM_194257 Q3THR7 Q8BNN4 Q8BT26 Q8C569 uc009ota.1 uc009ota.2 uc009ota.3 uc009ota.4 May play a role in Cajal bodies formation. Nucleus, Cajal body Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C569-1; Sequence=Displayed; Name=2; IsoId=Q8C569-2; Sequence=VSP_026730; Belongs to the FAM118 family. molecular_function cellular_component nucleus biological_process Cajal body Cajal body organization uc009ota.1 uc009ota.2 uc009ota.3 uc009ota.4 
ENSMUST00000059078.4 Fam43a ENSMUST00000059078.4 family with sequence similarity 43, member A (from RefSeq NM_177632.3) A4FTY9 ENSMUST00000059078.1 ENSMUST00000059078.2 ENSMUST00000059078.3 FA43A_MOUSE NM_177632 Q8BUP8 Q8R231 uc007ywy.1 uc007ywy.2 uc007ywy.3 Belongs to the FAM43 family. molecular_function cellular_component biological_process uc007ywy.1 uc007ywy.2 uc007ywy.3 
ENSMUST00000059080.7 Rps21 ENSMUST00000059080.7 ribosomal protein S21, transcript variant 2 (from RefSeq NM_025587.2) ENSMUST00000059080.1 ENSMUST00000059080.2 ENSMUST00000059080.3 ENSMUST00000059080.4 ENSMUST00000059080.5 ENSMUST00000059080.6 NM_025587 Q5M9L3 Q9CQR2 RS21_MOUSE uc008oir.1 uc008oir.2 uc008oir.3 Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the 40S small ribosomal subunit. Cytoplasm, cytosol Cytoplasm Rough endoplasmic reticulum Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). Belongs to the eukaryotic ribosomal protein eS21 family. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation structural constituent of ribosome cytoplasm endoplasmic reticulum rough endoplasmic reticulum cytosol ribosome translation cytosolic small ribosomal subunit polysomal ribosome ribosome binding synapse protein N-terminus binding uc008oir.1 uc008oir.2 uc008oir.3 
ENSMUST00000059091.6 Clca3a1 ENSMUST00000059091.6 chloride channel accessory 3A1, transcript variant 1 (from RefSeq NM_009899.4) B7ZN73 CA3A1_MOUSE Clca1 Clca3a1 ENSMUST00000059091.1 ENSMUST00000059091.2 ENSMUST00000059091.3 ENSMUST00000059091.4 ENSMUST00000059091.5 NM_009899 O88860 Q3UQR1 Q8C324 Q8CCM1 Q9QX15 uc008rpx.1 uc008rpx.2 uc008rpx.3 uc008rpx.4 Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner. Cell membrane ; Peripheral membrane protein Highly expressed in skin and spleen, and at lower levels in kidney and liver (PubMed:9822685, PubMed:10072771). Also detected in lung and brain (PubMed:9822685). Not detected in lung or brain (PubMed:10072771). In lung, localizes to respiratory epithelia of the bronchi and trachea and the submucosal glands (PubMed:9822685). Glycosylated. The 130-kDa product is autoproteolytically processed by the metalloprotease domain and yields two subunits, a 90-kDa protein and a group of 32- to 38-kDa proteins (PubMed:9822685). The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity (By similarity). Belongs to the CLCR family. intracellular calcium activated chloride channel activity plasma membrane integral component of plasma membrane proteolysis ion transport chloride transport peptidase activity metallopeptidase activity membrane hydrolase activity ion transmembrane transport metal ion binding uc008rpx.1 uc008rpx.2 uc008rpx.3 uc008rpx.4 
ENSMUST00000059093.7 Coa6 ENSMUST00000059093.7 cytochrome c oxidase assembly factor 6 (from RefSeq NM_174987.5) COA6_MOUSE ENSMUST00000059093.1 ENSMUST00000059093.2 ENSMUST00000059093.3 ENSMUST00000059093.4 ENSMUST00000059093.5 ENSMUST00000059093.6 NM_174987 Q8BGD8 uc009nyu.1 uc009nyu.2 uc009nyu.3 uc009nyu.4 Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. Found in a complex with TMEM177, COX20, MT-CO2/COX2, COX18, SCO1 and SCO2. Interacts with COA1, MT-CO2/COX2, SCO1, SCO2 and COX20. Interacts with COX20 in a MT-CO2/COX2- and COX18-dependent manner. Interacts with COX16. Mitochondrion Mitochondrion intermembrane space Belongs to the cytochrome c oxidase subunit 6B family. copper ion binding mitochondrion mitochondrial intermembrane space plasma membrane biological_process respiratory chain complex IV assembly plasma membrane ATP synthesis coupled electron transport host cell mitochondrial intermembrane space uc009nyu.1 uc009nyu.2 uc009nyu.3 uc009nyu.4 
ENSMUST00000059121.5 Ubqlnl ENSMUST00000059121.5 ubiquilin-like (from RefSeq NM_198624.3) E9QM12 ENSMUST00000059121.1 ENSMUST00000059121.2 ENSMUST00000059121.3 ENSMUST00000059121.4 NM_198624 Q14DL0 Q14DR8 Q8BVT0 UBQLN_MOUSE uc009ivl.1 uc009ivl.2 cytosol ubiquitin-dependent protein catabolic process polyubiquitin binding uc009ivl.1 uc009ivl.2 
ENSMUST00000059138.6 Prr15 ENSMUST00000059138.6 proline rich 15 (from RefSeq NM_030024.3) ENSMUST00000059138.1 ENSMUST00000059138.2 ENSMUST00000059138.3 ENSMUST00000059138.4 ENSMUST00000059138.5 G90 NM_030024 PRR15_MOUSE Q9D1T5 uc009bzu.1 uc009bzu.2 uc009bzu.3 May have a role in proliferation and/or differentiation. Exhibits a cell type specific expression pattern only in the small and large intestine and in the testis. Along the intestinal tract expression is restricted to the non-proliferating epithelial cells surrounding the villi and no expression is found in the intestinal crypts, where proliferation occurs. In the testis, it is detected only in post-mitotic secondary spermatocytes. Expressed in specific structures of the developing head, namely the brain, inner and middle ear, olfactory epithelium, vomeronasal organ, nasopharynx, oropharynx, papillae of the tongue and oral cavity, pituitary gland and epiglottis. Belongs to the PRR15 family. molecular_function cellular_component multicellular organism development biological_process uc009bzu.1 uc009bzu.2 uc009bzu.3 
ENSMUST00000059155.11 Insig1 ENSMUST00000059155.11 insulin induced gene 1 (from RefSeq NM_153526.5) A2RSM6 ENSMUST00000059155.1 ENSMUST00000059155.10 ENSMUST00000059155.2 ENSMUST00000059155.3 ENSMUST00000059155.4 ENSMUST00000059155.5 ENSMUST00000059155.6 ENSMUST00000059155.7 ENSMUST00000059155.8 ENSMUST00000059155.9 INSI1_MOUSE Insig1 NM_153526 Q3UAX9 Q3UX30 Q8BGI3 uc012dtq.1 uc012dtq.2 uc012dtq.3 Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:16100574). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:16100574). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (By similarity). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (By similarity). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (By similarity). Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); association is mediated via its interaction with SCAP and only takes place in the presence of sterols. Interacts with HMGCR (via its SSD); the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with AMFR/gp78 (via its membrane domain); the interaction recruits HMCR at the ER membrane for its ubiquitination and degradation by the sterol-mediated ERAD pathway. Interacts with SOAT2/ACAT2; leading to promote recruitment of AMFR/gp78 and subsequent ubiquitination of SOAT2/ACAT2. Interacts with RNF139. Interacts with RNF145. Endoplasmic reticulum membrane ; Multi-pass membrane protein Up-regulated progressively in the fat tissue as they develop diet-induced obesity (PubMed:12869692). Up-regulated in differentiating preadipocytes (PubMed:12869692). The KxHxx motif mediates association with the coatomer complex. Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4. Phosphorylation at Ser-189 by PCK1 reduces binding to oxysterol, disrupting the interaction between INSIG1 and SCAP, thereby promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis- related genes. Ubiquitinated by AMFR/gp78 in response to sterol deprivation, leading to its degradation: when the SCAP-SREBP complex becomes dissociated from INSIG1, INSIG1 is then ubiquitinated and degraded in proteasomes. Although ubiquitination is required for rapid INSIG1 degradation, it is not required for release of the SCAP-SREBP complex. Ubiquitinated by RNF139. Knockout mice with a conditional deletion of Insig1 in the liver and a germline deletion of Insig2 overaccumulate cholesterol and triglycerides in liver: despite this accumulation, levels of nuclear sterol regulatory element-binding proteins (SREBPs) are not reduced (PubMed:16100574). The amount of HMGCR is also elevated, caused by impaired degradation of the enzyme (PubMed:16100574). Knockout mice with a germline deletion of both Insig1 and Insig2 die within one day of birth (PubMed:16100574, PubMed:16955138). After 18.5 days of development, embryos lacking both Insig1 and Insig2 show defects in midline facial development, ranging from cleft palate to complete cleft face: middle and inner ear structures are abnormal, but teeth and skeletons are normal (PubMed:16955138). The livers and heads of embryos lacking both Insig1 and Insig2 overproduce sterols, causing a marked buildup of sterol intermediates (PubMed:16955138). Belongs to the INSIG family. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process triglyceride metabolic process cholesterol biosynthetic process response to sterol depletion steroid metabolic process cholesterol metabolic process negative regulation of steroid biosynthetic process membrane integral component of membrane sterol biosynthetic process SREBP signaling pathway SREBP-SCAP-Insig complex cellular response to sterol SREBP-SCAP complex retention in endoplasmic reticulum inner ear morphogenesis middle ear morphogenesis cholesterol homeostasis negative regulation of fat cell differentiation negative regulation of fatty acid biosynthetic process palate development cranial suture morphogenesis negative regulation of protein exit from endoplasmic reticulum negative regulation of cargo loading into COPII-coated vesicle uc012dtq.1 uc012dtq.2 uc012dtq.3 
ENSMUST00000059193.7 F2r ENSMUST00000059193.7 coagulation factor II thrombin receptor (from RefSeq NM_010169.4) Cf2r ENSMUST00000059193.1 ENSMUST00000059193.2 ENSMUST00000059193.3 ENSMUST00000059193.4 ENSMUST00000059193.5 ENSMUST00000059193.6 NM_010169 P30558 P97507 PAR1_MOUSE Par1 Q3TVP3 uc007rmn.1 uc007rmn.2 uc007rmn.3 High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. Cell membrane; Multi-pass membrane protein. The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor peptide known as parstatin. Proteolytic cleavage by thrombin generates a new N-terminus that functions as a tethered ligand. Also proteolytically cleaved by cathepsin CTSG. Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor. Belongs to the G-protein coupled receptor 1 family. activation of MAPKK activity G-protein alpha-subunit binding connective tissue replacement involved in inflammatory response wound healing negative regulation of glomerular filtration G-protein coupled receptor activity receptor binding early endosome late endosome plasma membrane integral component of plasma membrane caveola activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration protein kinase C-activating G-protein coupled receptor signaling pathway establishment of synaptic specificity at neuromuscular junction blood coagulation hemostasis positive regulation of cell proliferation negative regulation of cell proliferation response to wounding cell surface positive regulation of phosphatidylinositol 3-kinase signaling thrombin-activated receptor activity membrane integral component of membrane platelet activation regulation of blood coagulation positive regulation of blood coagulation positive regulation of cell migration platelet dense tubular network neuromuscular junction G-protein beta-subunit binding response to lipopolysaccharide regulation of interleukin-1 beta production heterotrimeric G-protein binding positive regulation of collagen biosynthetic process positive regulation of Rho protein signal transduction positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of GTPase activity postsynaptic membrane cell-cell junction maintenance positive regulation of transcription, DNA-templated positive regulation of vasoconstriction positive regulation of smooth muscle contraction positive regulation of JAK-STAT cascade homeostasis of number of cells within a tissue release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway positive regulation of calcium ion transport regulation of sensory perception of pain positive regulation of ERK1 and ERK2 cascade thrombin-activated receptor signaling pathway trans-synaptic signaling by endocannabinoid, modulating synaptic transmission negative regulation of renin secretion into blood stream positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion uc007rmn.1 uc007rmn.2 uc007rmn.3 
ENSMUST00000059199.7 Zfp764 ENSMUST00000059199.7 zinc finger protein 764, transcript variant 1 (from RefSeq NM_146203.4) E9QAP1 E9QAP1_MOUSE ENSMUST00000059199.1 ENSMUST00000059199.2 ENSMUST00000059199.3 ENSMUST00000059199.4 ENSMUST00000059199.5 ENSMUST00000059199.6 NM_146203 Zfp764 uc009jvi.1 uc009jvi.2 Nucleus nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009jvi.1 uc009jvi.2 
ENSMUST00000059204.11 Fbxl7 ENSMUST00000059204.11 F-box and leucine-rich repeat protein 7 (from RefSeq NM_176959.3) ENSMUST00000059204.1 ENSMUST00000059204.10 ENSMUST00000059204.2 ENSMUST00000059204.3 ENSMUST00000059204.4 ENSMUST00000059204.5 ENSMUST00000059204.6 ENSMUST00000059204.7 ENSMUST00000059204.8 ENSMUST00000059204.9 FBXL7_MOUSE Kiaa0840 NM_176959 Q5BJ29 Q6ZQ36 uc007vjn.1 uc007vjn.2 uc007vjn.3 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:22306998, PubMed:25778398). During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (PubMed:22306998). It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 (PubMed:25778398). Protein modification; protein ubiquitination. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7 (PubMed:22306998). Interacts with AURKA; interaction takes place during mitosis but not in interphase (PubMed:22306998). Interacts with BIRC5; this interaction allows BIRC5 to be polyubiquitinated by the SCF(FBXL7) E3 ubiquitin-protein ligase complex (PubMed:25778398). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to the centrosome during spindle formation. Belongs to the FBXL7 family. Sequence=BAC98037.1; Type=Erroneous initiation; Evidence=; G2/M transition of mitotic cell cycle mitotic cell cycle protein binding cytoplasm centrosome microtubule organizing center cytoskeleton ubiquitin-dependent protein catabolic process cell cycle cell proliferation protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process cell division ubiquitin-protein transferase activity uc007vjn.1 uc007vjn.2 uc007vjn.3 
ENSMUST00000059206.8 Pstpip1 ENSMUST00000059206.8 proline-serine-threonine phosphatase-interacting protein 1, transcript variant 1 (from RefSeq NM_011193.3) A0A0R4J0P5 A0A0R4J0P5_MOUSE ENSMUST00000059206.1 ENSMUST00000059206.2 ENSMUST00000059206.3 ENSMUST00000059206.4 ENSMUST00000059206.5 ENSMUST00000059206.6 ENSMUST00000059206.7 NM_011193 Pstpip1 uc009psv.1 uc009psv.2 uc009psv.3 uc009psv.4 identical protein binding uc009psv.1 uc009psv.2 uc009psv.3 uc009psv.4 
ENSMUST00000059216.5 Or2b28 ENSMUST00000059216.5 olfactory receptor family 2 subfamily B member 28 (from RefSeq NM_146533.1) ENSMUST00000059216.1 ENSMUST00000059216.2 ENSMUST00000059216.3 ENSMUST00000059216.4 NM_146533 Olfr1367 Or2b28 Q8VFG2 Q8VFG2_MOUSE uc007pqc.1 uc007pqc.2 uc007pqc.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007pqc.1 uc007pqc.2 uc007pqc.3 
ENSMUST00000059226.7 Ifi205 ENSMUST00000059226.7 interferon activated gene 205 (from RefSeq NM_172648.3) ENSMUST00000059226.1 ENSMUST00000059226.2 ENSMUST00000059226.3 ENSMUST00000059226.4 ENSMUST00000059226.5 ENSMUST00000059226.6 IFI5A_MOUSE Ifi205a NM_172648 Q8BYE7 Q8CGE8 uc007dsm.1 uc007dsm.2 uc007dsm.3 May act as a transcriptional regulator in the myeloid lineage. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways (By similarity). Nucleus Belongs to the HIN-200 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding activation of innate immune response double-stranded DNA binding nucleus nucleolus cytosol transcription factor binding response to bacterium positive regulation of interleukin-1 beta production cellular response to interferon-beta identical protein binding uc007dsm.1 uc007dsm.2 uc007dsm.3 
ENSMUST00000059229.16 Pgam5 ENSMUST00000059229.16 phosphoglycerate mutase family member 5, transcript variant 2 (from RefSeq NM_028273.3) B2RSM6 ENSMUST00000059229.1 ENSMUST00000059229.10 ENSMUST00000059229.11 ENSMUST00000059229.12 ENSMUST00000059229.13 ENSMUST00000059229.14 ENSMUST00000059229.15 ENSMUST00000059229.2 ENSMUST00000059229.3 ENSMUST00000059229.4 ENSMUST00000059229.5 ENSMUST00000059229.6 ENSMUST00000059229.7 ENSMUST00000059229.8 ENSMUST00000059229.9 NM_028273 PGAM5_MOUSE Q3UK19 Q80VY8 Q8BM78 Q8BX10 Q9CZU2 uc008yqh.1 uc008yqh.2 uc008yqh.3 uc008yqh.4 Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression (By similarity). Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Dimer. Forms a ternary complex with NFE2L2 and KEAP1. Interacts with BCL2L1 and MAP3K5 (By similarity). Upon TNF-induced necrosis, forms in complex with RIPK1, RIPK3 and MLKL; the formation of this complex leads to PGAM5 phosphorylation (By similarity). Interacts with DNM1L; this interaction leads to DNM1L dephosphorylation and activation and eventually to mitochondria fragmentation (By similarity). Mitochondrion outer membrane ; Single-pass membrane protein Mitochondrion inner membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BX10-1; Sequence=Displayed; Name=2; IsoId=Q8BX10-2; Sequence=VSP_025762; The N-terminal 35 amino acids, including the potential transmembrane alpha-helix, function as a non-cleaved mitochondrial targeting sequence that targets the protein to the cytosolic side of the outer mitochondrial membrane. Phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity (By similarity). Proteolytically cleaved by PARL in response to loss of mitochondrial membrane potential. Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. Sequence=BAB28067.1; Type=Frameshift; Evidence=; phosphoprotein phosphatase activity protein serine/threonine phosphatase activity GTPase activator activity mitochondrion mitochondrial outer membrane protein dephosphorylation programmed cell death membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity positive regulation of GTPase activity macromolecular complex binding necroptotic process uc008yqh.1 uc008yqh.2 uc008yqh.3 uc008yqh.4 
ENSMUST00000059231.4 Frat2 ENSMUST00000059231.4 frequently rearranged in advanced T cell lymphomas 2 (from RefSeq NM_177603.3) ENSMUST00000059231.1 ENSMUST00000059231.2 ENSMUST00000059231.3 FRAT2_MOUSE NM_177603 Q8K025 uc008hmj.1 uc008hmj.2 uc008hmj.3 uc008hmj.4 uc008hmj.5 Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. Binds GSK-3 and prevents GSK-3-dependent phosphorylation. Belongs to the GSK-3-binding protein family. molecular_function cytoplasm Wnt signaling pathway uc008hmj.1 uc008hmj.2 uc008hmj.3 uc008hmj.4 uc008hmj.5 
ENSMUST00000059241.8 Sprn ENSMUST00000059241.8 shadow of prion protein (from RefSeq NM_183147.2) ENSMUST00000059241.1 ENSMUST00000059241.2 ENSMUST00000059241.3 ENSMUST00000059241.4 ENSMUST00000059241.5 ENSMUST00000059241.6 ENSMUST00000059241.7 Gm169 NM_183147 Q8BWU1 SPRN_MOUSE uc009khe.1 uc009khe.2 uc009khe.3 Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP. Cell membrane ; Lipid-anchor, GPI-anchor Mainly expressed in brain (at protein level). In brain, it is highly expressed in the hippocampus and cerebellum and is also expressed at lower level in other areas of the brain including the cerebral cortex, the thalamus and the medulla. In hippocampus and cerebellum it is highly expressed in the cell bodies of pyramidal cells and Purkinje cells, respectively. Appears at embryonic day 16 and persists in early postnatal life and in the brains of adults (at protein level). Strongly down-regulated in prion-infected brains (at protein level). N-glycosylated. This protein is a candidate for 'Pi' factor, a PrP(C)- like protein able to compensate for the absence of PrPC in mice lacking Prnp. Belongs to the SPRN family. nucleic acid binding nucleus nucleolus cytosol plasma membrane protein import into nucleus membrane anchored component of membrane vesicle uc009khe.1 uc009khe.2 uc009khe.3 
ENSMUST00000059250.8 Brms1l ENSMUST00000059250.8 breast cancer metastasis-suppressor 1-like, transcript variant 2 (from RefSeq NR_155205.1) BRM1L_MOUSE ENSMUST00000059250.1 ENSMUST00000059250.2 ENSMUST00000059250.3 ENSMUST00000059250.4 ENSMUST00000059250.5 ENSMUST00000059250.6 ENSMUST00000059250.7 NR_155205 Q3U1T3 Q8JZX8 uc007npa.1 uc007npa.2 uc007npa.3 Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth (By similarity). Component of the Sin3/HDAC1 corepressor complex at least composed of BRMS1, BRMS1L and ING2/ING1L. Interacts with HDAC and SIN3A (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U1T3-1; Sequence=Displayed; Name=2; IsoId=Q3U1T3-2; Sequence=VSP_028347, VSP_028348; Belongs to the BRMS1 family. negative regulation of transcription from RNA polymerase II promoter nucleus histone deacetylation regulation of growth histone deacetylase binding Sin3-type complex histone deacetylase activity uc007npa.1 uc007npa.2 uc007npa.3 
ENSMUST00000059270.10 Heatr1 ENSMUST00000059270.10 HEAT repeat containing 1 (from RefSeq NM_144835.4) ENSMUST00000059270.1 ENSMUST00000059270.2 ENSMUST00000059270.3 ENSMUST00000059270.4 ENSMUST00000059270.5 ENSMUST00000059270.6 ENSMUST00000059270.7 ENSMUST00000059270.8 ENSMUST00000059270.9 G3X9B1 G3X9B1_MOUSE Heatr1 NM_144835 uc007plk.1 uc007plk.2 uc007plk.3 Involved in nucleolar processing of pre-18S ribosomal RNA. Nucleus, nucleolus Belongs to the HEATR1/UTP10 family. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) fibrillar center nucleolus mitochondrion 90S preribosome small-subunit processome t-UTP complex positive regulation of transcription from RNA polymerase I promoter positive regulation of rRNA processing uc007plk.1 uc007plk.2 uc007plk.3 
ENSMUST00000059271.13 St7l ENSMUST00000059271.13 suppression of tumorigenicity 7-like, transcript variant 4 (from RefSeq NR_045578.1) ENSMUST00000059271.1 ENSMUST00000059271.10 ENSMUST00000059271.11 ENSMUST00000059271.12 ENSMUST00000059271.2 ENSMUST00000059271.3 ENSMUST00000059271.4 ENSMUST00000059271.5 ENSMUST00000059271.6 ENSMUST00000059271.7 ENSMUST00000059271.8 ENSMUST00000059271.9 NR_045578 Q3T9Y2 Q3UNR1 Q8K4P7 ST7L_MOUSE St7r uc008qur.1 uc008qur.2 uc008qur.3 uc008qur.4 uc008qur.5 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K4P7-1; Sequence=Displayed; Name=2; IsoId=Q8K4P7-2; Sequence=VSP_034138; Name=3; IsoId=Q8K4P7-3; Sequence=VSP_034137; Ubiquitously expressed. Belongs to the ST7 family. molecular_function cellular_component membrane integral component of membrane negative regulation of cell growth uc008qur.1 uc008qur.2 uc008qur.3 uc008qur.4 uc008qur.5 
ENSMUST00000059272.10 Hoxd9 ENSMUST00000059272.10 homeobox D9 (from RefSeq NM_013555.4) A2ASM9 ENSMUST00000059272.1 ENSMUST00000059272.2 ENSMUST00000059272.3 ENSMUST00000059272.4 ENSMUST00000059272.5 ENSMUST00000059272.6 ENSMUST00000059272.7 ENSMUST00000059272.8 ENSMUST00000059272.9 HXD9_MOUSE Hox-4.4 Hoxd-9 NM_013555 P28357 Q3UMQ3 Q3UYS2 uc008kdz.1 uc008kdz.2 uc008kdz.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus. Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the first lumbar pre-vertebrae. Belongs to the Abd-B homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleolus transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development single fertilization skeletal muscle tissue development adult locomotory behavior anterior/posterior pattern specification proximal/distal pattern formation regulation of gene expression mammary gland development embryonic forelimb morphogenesis forelimb morphogenesis hindlimb morphogenesis sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system morphogenesis embryonic skeletal system development peripheral nervous system neuron development uc008kdz.1 uc008kdz.2 uc008kdz.3 
ENSMUST00000059279.13 Lrrc37 ENSMUST00000059279.13 Lrrc37 (from geneSymbol) A2A9H6 A2A9H6_MOUSE AK029868 ENSMUST00000059279.1 ENSMUST00000059279.10 ENSMUST00000059279.11 ENSMUST00000059279.12 ENSMUST00000059279.2 ENSMUST00000059279.3 ENSMUST00000059279.4 ENSMUST00000059279.5 ENSMUST00000059279.6 ENSMUST00000059279.7 ENSMUST00000059279.8 ENSMUST00000059279.9 Lrrc37 uc288cuh.1 uc288cuh.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288cuh.1 uc288cuh.2 
ENSMUST00000059286.14 Irak2 ENSMUST00000059286.14 interleukin-1 receptor-associated kinase 2, transcript variant 1 (from RefSeq NM_172161.4) ENSMUST00000059286.1 ENSMUST00000059286.10 ENSMUST00000059286.11 ENSMUST00000059286.12 ENSMUST00000059286.13 ENSMUST00000059286.2 ENSMUST00000059286.3 ENSMUST00000059286.4 ENSMUST00000059286.5 ENSMUST00000059286.6 ENSMUST00000059286.7 ENSMUST00000059286.8 ENSMUST00000059286.9 IRAK2_MOUSE NM_172161 Q3U3K2 Q3U7F5 Q3UFX2 Q5U404 Q6YBR8 Q6YBR9 Q6YBS0 Q6YBS1 Q8C5M0 Q8CC82 Q8CEA0 Q8CFA1 uc009dhc.1 uc009dhc.2 uc009dhc.3 uc009dhc.4 uc009dhc.5 Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1 (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=IRAK-2a; IsoId=Q8CFA1-1; Sequence=Displayed; Name=2; Synonyms=IRAK-2b; IsoId=Q8CFA1-2; Sequence=VSP_023027; Name=3; Synonyms=IRAK-2d; IsoId=Q8CFA1-3; Sequence=VSP_023026, VSP_023028; Name=4; Synonyms=IRAK-2c; IsoId=Q8CFA1-4; Sequence=VSP_023025; Ubiquitously expressed, with a higher expression observed in brain, spleen and liver. Isoform 1 and isoform 2 are considered agonist and isoform 3 and isoform 4 are considered antagonist. The protein kinase domain is predicted to be catalytically inactive. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Asn-333 is present instead of the conserved Asp which is expected to be an active site residue. nucleotide binding regulation of cytokine-mediated signaling pathway MyD88-dependent toll-like receptor signaling pathway protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm protein phosphorylation inflammatory response signal transduction I-kappaB kinase/NF-kappaB signaling cytokine-mediated signaling pathway lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity intracellular signal transduction protein homodimerization activity regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity protein heterodimerization activity positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway response to interleukin-1 activation of NF-kappaB-inducing kinase activity protein autophosphorylation uc009dhc.1 uc009dhc.2 uc009dhc.3 uc009dhc.4 uc009dhc.5 
ENSMUST00000059295.10 Syt12 ENSMUST00000059295.10 synaptotagmin XII (from RefSeq NM_134164.5) ENSMUST00000059295.1 ENSMUST00000059295.2 ENSMUST00000059295.3 ENSMUST00000059295.4 ENSMUST00000059295.5 ENSMUST00000059295.6 ENSMUST00000059295.7 ENSMUST00000059295.8 ENSMUST00000059295.9 NM_134164 Q920N7 SYT12_MOUSE Syt12 uc008gad.1 uc008gad.2 uc008gad.3 Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (By similarity). Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids (By similarity). Essential for mossy-fiber long-term potentiation in the hippocampus (PubMed:23739973). Homodimer (By similarity). Can also form heterodimers (By similarity). Interacts with SYT1 (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein Expressed in the brain, specifically by neurons in the hippocampus, and in the adrenal medulla (at protein level). Detected at low levels in the brain at postnatal day 5 (at protein level) (PubMed:17190793). Expression in the brain is increased by postnatal days 9 and 10, and continues to increase at postnatal days 15 and 20 (at protein level) (PubMed:17190793). Phosphorylation of Ser-97 is required for mossy-fiber long-term potentiation. No measurable change in basal synaptic strength or short-term neuronal plasticity (PubMed:23739973). Neurons from the CA3 hippocampal region exhibit an impairment of cAMP-dependent long- term potentiation in mossy-fiber synapses (PubMed:23739973). Belongs to the synaptotagmin family. Unlike classical synaptotagmins, lacks Ca(2+)-binding sequences and does not bind phospholipids. SNARE binding phosphatidylserine binding calcium ion binding calcium-dependent phospholipid binding plasma membrane synaptic vesicle regulation of dopamine secretion membrane integral component of membrane vesicle-mediated transport calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis syntaxin binding cell junction clathrin binding synaptic vesicle membrane cytoplasmic vesicle synapse regulation of neurotransmitter secretion spontaneous exocytosis of neurotransmitter long-term synaptic potentiation exocytic vesicle cellular response to calcium ion presynapse uc008gad.1 uc008gad.2 uc008gad.3 
ENSMUST00000059319.8 Tmem17 ENSMUST00000059319.8 transmembrane protein 17 (from RefSeq NM_153596.3) ENSMUST00000059319.1 ENSMUST00000059319.2 ENSMUST00000059319.3 ENSMUST00000059319.4 ENSMUST00000059319.5 ENSMUST00000059319.6 ENSMUST00000059319.7 NM_153596 Q8K0U3 TMM17_MOUSE uc007iee.1 uc007iee.2 uc007iee.3 Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling. Part of the tectonic-like complex (also named B9 complex). Cell projection, cilium membrane ; Multi-pass membrane protein Note=Localizes to the transition zone of primary cilia. Belongs to the TMEM17 family. protein binding plasma membrane cilium smoothened signaling pathway membrane integral component of membrane cell projection organization ciliary transition zone MKS complex cell projection ciliary membrane cilium assembly non-motile cilium assembly uc007iee.1 uc007iee.2 uc007iee.3 
ENSMUST00000059320.4 Rnf138rt1 ENSMUST00000059320.4 ring finger protein 138, retrogene 1 (from RefSeq NM_028842.3) 1700045I19Rik ENSMUST00000059320.1 ENSMUST00000059320.2 ENSMUST00000059320.3 NM_028842 Q9D9M9 Q9D9M9_MOUSE Rnf138rt1 uc009uuv.1 uc009uuv.2 uc009uuv.3 uc009uuv.4 Protein modification; protein ubiquitination. double-strand break repair via homologous recombination molecular_function single-stranded DNA binding cellular_component biological_process DNA double-strand break processing involved in repair via single-strand annealing protein ubiquitination site of double-strand break ubiquitin protein ligase activity uc009uuv.1 uc009uuv.2 uc009uuv.3 uc009uuv.4 
ENSMUST00000059331.9 Mypop ENSMUST00000059331.9 Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity. (from UniProt Q8R4U1) AF364868 ENSMUST00000059331.1 ENSMUST00000059331.2 ENSMUST00000059331.3 ENSMUST00000059331.4 ENSMUST00000059331.5 ENSMUST00000059331.6 ENSMUST00000059331.7 ENSMUST00000059331.8 MYPOP_MOUSE P42pop Q7TNR1 Q8CFP0 Q8R4U1 uc009fka.1 uc009fka.2 uc009fka.3 uc009fka.4 Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity. Interacts with PFN1. Homodimer and heterodimer with PFN1. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R4U1-1; Sequence=Displayed; Name=2; IsoId=Q8R4U1-2; Sequence=VSP_034858, VSP_034859; Ubiquitous. Highly expressed in brain, liver and testis. Moderate expression in heart, lung and skeletal muscle. Low expression in spleen and kidney. The proline-rich region is required for PFN1 interaction. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription from RNA polymerase II promoter protein homodimerization activity uc009fka.1 uc009fka.2 uc009fka.3 uc009fka.4 
ENSMUST00000059339.6 Pnoc ENSMUST00000059339.6 prepronociceptin, transcript variant 1 (from RefSeq NM_010932.3) ENSMUST00000059339.1 ENSMUST00000059339.2 ENSMUST00000059339.3 ENSMUST00000059339.4 ENSMUST00000059339.5 NM_010932 Npnc1 PNOC_MOUSE Q61105 Q61938 Q64387 uc007uji.1 uc007uji.2 uc007uji.3 This gene encodes the precursor for neuropeptides that have been implicated in a wide range of physiological roles such as transmission and sensitivity to pain, learning, memory, anxiety and depression, in the central nervous system. The encoded protein is a precursor that is proteolytically processed to generate multiple biologically active peptides including nociceptin and nocistatin which have opposite functions in pain transmission. Mice lacking the encoded protein display increased anxiety, elevated basal pain threshold and impaired adaptation to repeated stress. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]. [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. When administered intracerebroventricularly, nociceptin induces hyperalgesia and decreases locomotor activity. [Nocistatin]: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia. [Orphanin FQ2]: Has potent analgesic activity. Secreted. Event=Alternative splicing; Named isoforms=2; Name=Short; Synonyms=N23K; IsoId=Q64387-1; Sequence=Displayed; Name=Long; Synonyms=N27K; IsoId=Q64387-2; Sequence=VSP_001446; Brain and spinal cord. Low levels in kidney and spleen. In embryonic brain, first detected at day 14 and in postnatal brain, levels increase in day 1 and day 18. Levels decrease significantly in adults. Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. Belongs to the opioid neuropeptide precursor family. opioid peptide activity extracellular region plasma membrane neuropeptide signaling pathway chemical synaptic transmission female pregnancy dendrite opioid receptor binding neuronal cell body axon terminus uc007uji.1 uc007uji.2 uc007uji.3 
ENSMUST00000059341.5 Zc2hc1c ENSMUST00000059341.5 zinc finger, C2HC-type containing 1C (from RefSeq NM_172414.4) ENSMUST00000059341.1 ENSMUST00000059341.2 ENSMUST00000059341.3 ENSMUST00000059341.4 Fam164c NM_172414 Q8CCG1 Q8CCM8 ZC21C_MOUSE uc007ogw.1 uc007ogw.2 uc007ogw.3 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Belongs to the ZC2HC1 family. molecular_function cellular_component biological_process metal ion binding uc007ogw.1 uc007ogw.2 uc007ogw.3 
ENSMUST00000059343.7 Epha10 ENSMUST00000059343.7 Eph receptor A10, transcript variant 2 (from RefSeq NM_177671.6) A2A7J5 ENSMUST00000059343.1 ENSMUST00000059343.2 ENSMUST00000059343.3 ENSMUST00000059343.4 ENSMUST00000059343.5 ENSMUST00000059343.6 EPHAA_MOUSE NM_177671 Q3UPV5 Q8BYG9 uc008urh.1 uc008urh.2 uc008urh.3 uc008urh.4 Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5 (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Cell membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BYG9-1; Sequence=Displayed; Name=2; IsoId=Q8BYG9-2; Sequence=VSP_023676, VSP_023677; Expressed in the cochlea, in the organ of Corti, spiral ganglion, and stria vascularis. The protein kinase domain is predicted to be catalytically inactive. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Sequence=CAM16104.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity transmembrane-ephrin receptor activity ATP binding plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway axon guidance membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation neuron projection receptor complex ephrin receptor signaling pathway uc008urh.1 uc008urh.2 uc008urh.3 uc008urh.4 
ENSMUST00000059348.9 Guca1a ENSMUST00000059348.9 guanylate cyclase activator 1a (retina) (from RefSeq NM_008189.3) ENSMUST00000059348.1 ENSMUST00000059348.2 ENSMUST00000059348.3 ENSMUST00000059348.4 ENSMUST00000059348.5 ENSMUST00000059348.6 ENSMUST00000059348.7 ENSMUST00000059348.8 GUC1A_MOUSE Gcap Gcap1 Guca1 NM_008189 P43081 Q8R0H3 uc008cvc.1 uc008cvc.2 uc008cvc.3 uc008cvc.4 This gene encodes a calcium-binding photoreceptor protein. The encoded protein may be involved in modulation of guanylyl cyclase activity, and in turn, the mammalian cone phototransduction cascade. Disruption of this gene results in the retinal degeneration associated with cone dystrophy. [provided by RefSeq, Dec 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026834.1, BG288581.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor light response and recovery of response in bright light (PubMed:25673692). Homodimer. Membrane; Lipid-anchor Photoreceptor inner segment Cell projection, cilium, photoreceptor outer segment te=Subcellular location is not affected by light or dark conditions. In the retina, expressed in rod photoreceptors (at protein level) (PubMed:9620085). Expressed in cone photoreceptors (PubMed:9620085). Binds three calcium ions (via EF-hands 2, 3 and 4) when calcium levels are high. Binds Mg(2+) when calcium levels are low. Guca1a and Guca1b double knockout mice show an increase in response to light in dark-adapted cone photoreceptors (PubMed:25673692). Dark-adapted cone photoreceptors show a delayed response time and a delayed recovery time in response to light (PubMed:25673692). Guca1a, Guca1b and Rcvrn triple knockout mice show rod photoreceptors have a reduced current decay during light response (PubMed:29435986). photoreceptor outer segment photoreceptor inner segment calcium ion binding visual perception phototransduction calcium sensitive guanylate cyclase activator activity positive regulation of cGMP-mediated signaling membrane guanylate cyclase regulator activity regulation of guanylate cyclase activity positive regulation of guanylate cyclase activity metal ion binding response to stimulus cellular response to calcium ion uc008cvc.1 uc008cvc.2 uc008cvc.3 uc008cvc.4 
ENSMUST00000059352.3 Lmod1 ENSMUST00000059352.3 leiomodin 1 (smooth muscle) (from RefSeq NM_053106.2) ENSMUST00000059352.1 ENSMUST00000059352.2 F8VPR1 F8VPR1_MOUSE Lmod1 NM_053106 uc007cta.1 uc007cta.2 uc007cta.3 Cytoplasm, myofibril, sarcomere Belongs to the tropomodulin family. actin binding tropomyosin binding cytosol actin filament muscle contraction myofibril sarcomere positive regulation of actin filament polymerization actin nucleation pointed-end actin filament capping uc007cta.1 uc007cta.2 uc007cta.3 
ENSMUST00000059354.15 Sigmar1 ENSMUST00000059354.15 sigma non-opioid intracellular receptor 1, transcript variant 1 (from RefSeq NM_011014.3) ENSMUST00000059354.1 ENSMUST00000059354.10 ENSMUST00000059354.11 ENSMUST00000059354.12 ENSMUST00000059354.13 ENSMUST00000059354.14 ENSMUST00000059354.2 ENSMUST00000059354.3 ENSMUST00000059354.4 ENSMUST00000059354.5 ENSMUST00000059354.6 ENSMUST00000059354.7 ENSMUST00000059354.8 ENSMUST00000059354.9 NM_011014 O55242 Oprs1 Q9JKU9 SGMR1_MOUSE uc008sjk.1 uc008sjk.2 uc008sjk.3 This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]. Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane (PubMed:12730355). Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:11149946, PubMed:14622179, PubMed:15571673, PubMed:15777781, PubMed:23332758, PubMed:9425306, PubMed:9603192). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria (PubMed:25678561). Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (PubMed:26792191). Homotrimer (By similarity). Interacts with KCNA4 (By similarity). Interacts with KCNA2; cocaine consumption leads to increased interaction (PubMed:23332758). Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists (PubMed:11149946). Interacts with RNF112 in an oxidative stress-regulated manner (PubMed:26792191). O55242; P63141: Kcna2; NbExp=3; IntAct=EBI-1557700, EBI-644033; O55242; G3I8R9: HSPA5; Xeno; NbExp=3; IntAct=EBI-1557700, EBI-988311; Nucleus inner membrane Nucleus outer membrane Nucleus envelope Cytoplasmic vesicle Endoplasmic reticulum membrane Membrane ; Single-pass membrane protein Lipid droplet Cell junction Cell membrane Cell projection, growth cone Postsynaptic density membrane Note=During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum. Detected on cytoplasmic vesicles during mitosis (By similarity). Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum (PubMed:12730355). Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. In motor neurons it is enriched at cholinergic postsynaptic densities (PubMed:20167253). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O55242-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=O55242-2; Sequence=VSP_021987; Widely expressed with higher expression in liver, brain, kidney and thymus. Expressed throughout the brain with higher expression within cerebral cortex, hippocampus and cerebellum. Within the hippocampus expressed in cornu ammonis pyramidal neurons, the granular cells of the dentate gyrus as well as interneurons. Within the cerebellum, expressed in Purkinje cell bodies (PubMed:11207432, PubMed:11476895, PubMed:11687279, PubMed:9603192). Highly expressed in the brainstem and motor neurons of the spinal cord (PubMed:20167253). Expressed by neural retina, retinal pigment epithelial cells and lens (PubMed:11207432, PubMed:11476895, PubMed:11687279, PubMed:9603192). The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane. Mice display decreased hypermotility response induced by (+)SKF-10047 challenge and reduced formalin-induced pain (PubMed:14622179). Mice display motor coordination defects, muscle weakness, partial neuromuscular junction innervation, and motor neuron degeneration (PubMed:20167253, PubMed:25678561). Depletion by RNAi enhances kappa-type opioid receptor- mediated analgesia and prevents the memory-improving effects of (-)- and (+)-pentazocine. Sigma receptors are classified into two subtypes (Sigma- 1 and Sigma-2) based on their different pharmacological profile. Belongs to the ERG2 family. opioid receptor activity protein binding nucleus nuclear envelope nuclear inner membrane nuclear outer membrane endoplasmic reticulum endoplasmic reticulum membrane lipid particle plasma membrane lipid transport nervous system development postsynaptic density membrane integral component of membrane cell junction growth cone cytoplasmic vesicle cell death in response to hydrogen peroxide opioid receptor signaling pathway signaling receptor activity identical protein binding cell projection regulation of neuron apoptotic process synapse postsynaptic membrane protein homotrimerization uc008sjk.1 uc008sjk.2 uc008sjk.3 
ENSMUST00000059362.3 Synb ENSMUST00000059362.3 syncytin b (from RefSeq NM_173420.3) ENSMUST00000059362.1 ENSMUST00000059362.2 NM_173420 Q8BI41 SYNB_MOUSE Synb V9GXQ5 uc029slc.1 uc029slc.2 uc029slc.3 Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK086309.1, BB662839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## endogenous retrovirus :: PMID: 15644441 RefSeq Select criteria :: based on longest protein ##RefSeq-Attributes-END## This endogenous retroviral envelope protein has retained its original fusogenic properties (PubMed:15644441, PubMed:18077339, PubMed:22032925, PubMed:27589388). Together with Syna, participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis (PubMed:22032925). Synb is specifically involved in formation of syncytiotrophoblast layer II (SynT-II) (PubMed:22032925). Promotes myoblast fusion, and may play a role in regeneration of damaged muscle tissue in males (PubMed:27589388). May have immunosuppressive activity (PubMed:18077339). The mature protein consists of a trimer of SU-TM heterodimers (Probable). The SU-TM heterodimers are attached by a labile interchain disulfide bond (By similarity). [Surface protein]: Cell membrane ; Peripheral membrane protein Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. [Transmembrane protein]: Cell membrane ; Single-pass membrane protein Highly expressed in placenta where it localizes to syncytiotrophoblasts of the labyrinthine zona (PubMed:15644441). Specifically localizes to syncytiotrophoblast layer II (SynT-II) (PubMed:18448564). Also detected at very low levels in ovary (PubMed:15644441). Expressed in the placental labyrinth from stage 8.5 dpc onwards. In males, up-regulated in regenerating muscle tissue after injury. Synthesized as an inactive precursor that is heavily N- glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion. Viable, although growth is retarded and neonate numbers are reduced (PubMed:22032925). In the placental labyrinth, formation of syncytiotrophoblast layer II (SynT-II) is abnormal with reduced cell fusion and progressive expansion of maternal blood lacunae(PubMed:22032925). Unfused SynT-II cells form dense plaque-like structures between adjacent cells, which resemble cell junctions and are associated with high expression levels of GJB6/connexin-30 (PubMed:22032925). Formation of syncytiotrophoblast layer I (SynT-I) is grossly normal (PubMed:22032925). Adult male mice have a 15% reduction in muscle mass compared to wild type, probably due to defects in myoblast fusion (PubMed:27589388). Double knockouts of Syna and Synb are embryonic lethal at stage 9.5 dpc to 10.5 dpc, indicating a more severe phenotype than the Syna single knockout (PubMed:22032925). The mouse genome contains a high percentage of proviral- like elements, also called endogenous retroviruses (ERVs) that are the genomic traces of ancient infections of the germline by exogenous retroviruses. Although most of these elements are defective, some have conserved a functional envelope (env) gene, most probably diverted by the host for its benefit. Belongs to the gamma type-C retroviral envelope protein family. syncytium formation by plasma membrane fusion molecular_function cellular_component plasma membrane syncytium formation multicellular organism development membrane integral component of membrane labyrinthine layer blood vessel development uc029slc.1 uc029slc.2 uc029slc.3 
ENSMUST00000059372.11 Rnf24 ENSMUST00000059372.11 ring finger protein 24 (from RefSeq NM_178607.5) ENSMUST00000059372.1 ENSMUST00000059372.10 ENSMUST00000059372.2 ENSMUST00000059372.3 ENSMUST00000059372.4 ENSMUST00000059372.5 ENSMUST00000059372.6 ENSMUST00000059372.7 ENSMUST00000059372.8 ENSMUST00000059372.9 NM_178607 Q8BGI1 RNF24_MOUSE uc008mll.1 uc008mll.2 uc008mll.3 uc008mll.4 May play a role in TRPCs intracellular trafficking. Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. Golgi apparatus membrane ; Single- pass membrane protein Golgi membrane Golgi apparatus zinc ion binding endomembrane system membrane integral component of membrane protein ubiquitination metal ion binding ubiquitin protein ligase activity uc008mll.1 uc008mll.2 uc008mll.3 uc008mll.4 
ENSMUST00000059383.8 Fhl4 ENSMUST00000059383.8 four and a half LIM domains 4 (from RefSeq NM_010214.4) ENSMUST00000059383.1 ENSMUST00000059383.2 ENSMUST00000059383.3 ENSMUST00000059383.4 ENSMUST00000059383.5 ENSMUST00000059383.6 ENSMUST00000059383.7 Fhl4 NM_010214 Q8CDC8 Q8CDC8_MOUSE uc007gla.1 uc007gla.2 uc007gla.3 uc007gla.4 molecular_function cellular_component biological_process metal ion binding uc007gla.1 uc007gla.2 uc007gla.3 uc007gla.4 
ENSMUST00000059390.13 Vps35l ENSMUST00000059390.13 VPS35 endosomal protein sorting factor like (from RefSeq NM_027815.5) ENSMUST00000059390.1 ENSMUST00000059390.10 ENSMUST00000059390.11 ENSMUST00000059390.12 ENSMUST00000059390.2 ENSMUST00000059390.3 ENSMUST00000059390.4 ENSMUST00000059390.5 ENSMUST00000059390.6 ENSMUST00000059390.7 ENSMUST00000059390.8 ENSMUST00000059390.9 NM_027815 Q3UWS3 Q3UXM0 Q7TQF5 Q80XN3 Q8BWQ6 Q8R3A8 Q91VY3 Q9D307 VP35L_MOUSE Vps35l uc009jko.1 uc009jko.2 uc009jko.3 uc009jko.4 Acts as a component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability. Component of the heterotrimeric retriever complex formed by VPS26C, VPS29 and VPS35L. Interacts with VPS29. Interacts with COMMD1, CCDC93 and CCDC22; associates with the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain- containing proteins), CCDC22 and CCDC93. Interacts with WASHC1, WASHC2A and WASHC2C. Interacts with SNX17 and SNX31. Membrane ; Single-pass membrane protein Endosome Note=Endosome location is dependent of the association with the CCC and WASH complexes. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BWQ6-1; Sequence=Displayed; Name=2; IsoId=Q8BWQ6-2; Sequence=VSP_029541, VSP_029542; Name=3; IsoId=Q8BWQ6-3; Sequence=VSP_029539, VSP_029540; Homozygous VPS35L knockout is embryonic lethal at an early stage of embryo development, between 7.5 and 10.5 dpc. Belongs to the VPS35L family. molecular_function cell endosome Golgi to plasma membrane transport protein transport membrane integral component of membrane endocytic recycling retrograde transport, endosome to plasma membrane uc009jko.1 uc009jko.2 uc009jko.3 uc009jko.4 
ENSMUST00000059401.7 Atg9b ENSMUST00000059401.7 autophagy related 9B (from RefSeq NM_001002897.3) ATG9B_MOUSE Apg9l2 Atg9b ENSMUST00000059401.1 ENSMUST00000059401.2 ENSMUST00000059401.3 ENSMUST00000059401.4 ENSMUST00000059401.5 ENSMUST00000059401.6 F8VQL8 NM_001002897 Nos3as Q674R6 Q6EBV9 uc033ihy.1 uc033ihy.2 Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:15755735). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2- diacyl-sn-glycero-3-phosphoethanolamine(out); Xref=Rhea:RHEA:38895, ChEBI:CHEBI:64612; Evidence=; Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets. Preautophagosomal structure membrane ; Multi-pass membrane protein Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation-induced redistribution depends on ULK1 and ATG13. Expressed in heart, brain, and placenta and testis. Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer. Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of ATG9B-containing vesicles, thereby enabling growth into autophagosomes. The tyrosine-based sorting signal motif, also named YXX-psi motif, promotes interaction with the AP-4 complex. Belongs to the ATG9 family. Sequence=AAS87213.1; Type=Erroneous initiation; Evidence=; autophagosome assembly pre-autophagosomal structure autophagosome membrane mitophagy molecular_function cytoplasm autophagosome autophagy membrane integral component of membrane cytoplasmic vesicle protein localization to pre-autophagosomal structure late nucleophagy uc033ihy.1 uc033ihy.2 
ENSMUST00000059407.9 Slitrk3 ENSMUST00000059407.9 SLIT and NTRK-like family, member 3, transcript variant 2 (from RefSeq NM_001357851.1) ENSMUST00000059407.1 ENSMUST00000059407.2 ENSMUST00000059407.3 ENSMUST00000059407.4 ENSMUST00000059407.5 ENSMUST00000059407.6 ENSMUST00000059407.7 ENSMUST00000059407.8 NM_001357851 Q6NZM5 Q810B9 SLIK3_MOUSE uc008pmt.1 uc008pmt.2 Suppresses neurite outgrowth. Membrane ; Single-pass type I membrane protein Broadly expressed in embryonic brain with highest expression in cortical plate, pyramidal cell layer of the hippocampus, thalamus and hypothalamus. Belongs to the SLITRK family. molecular_function axonogenesis membrane integral component of membrane positive regulation of synapse assembly GABA-ergic synapse integral component of postsynaptic membrane integral component of postsynaptic specialization membrane integral component of postsynaptic density membrane synaptic membrane adhesion regulation of presynapse assembly uc008pmt.1 uc008pmt.2 
ENSMUST00000059424.10 Tmprss11c ENSMUST00000059424.10 transmembrane protease, serine 11c (from RefSeq NM_001030297.3) ENSMUST00000059424.1 ENSMUST00000059424.2 ENSMUST00000059424.3 ENSMUST00000059424.4 ENSMUST00000059424.5 ENSMUST00000059424.6 ENSMUST00000059424.7 ENSMUST00000059424.8 ENSMUST00000059424.9 NM_001030297 Q1JRP2 TM11C_MOUSE Tmprss11c uc008xxn.1 uc008xxn.2 Serine protease which has a preference for Arg or Lys in position P1 and uncharged residues in positions P2 and P3. Shows specificity towards FGF2 in vitro. pH dependence: Optimum pH is 8. ; Cell membrane ; Single-pass type II membrane protein Cell projection, dendrite Perikaryon Expressed specifically in Purkinje neurons of the cerebellum (at protein level). Also detected in spinal cord. Proteolytically cleaved via an autocatalytic mechanism. Belongs to the peptidase S1 family. serine-type endopeptidase activity extracellular region plasma membrane integral component of plasma membrane proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity dendrite cell projection perikaryon self proteolysis uc008xxn.1 uc008xxn.2 
ENSMUST00000059428.7 Ccdc149 ENSMUST00000059428.7 coiled-coil domain containing 149, transcript variant 2 (from RefSeq NM_001379231.1) Ccdc149 ENSMUST00000059428.1 ENSMUST00000059428.2 ENSMUST00000059428.3 ENSMUST00000059428.4 ENSMUST00000059428.5 ENSMUST00000059428.6 F6V035 F6V035_MOUSE NM_001379231 uc029vhk.1 uc029vhk.2 uc029vhk.3 Belongs to the CCDC149 family. molecular_function cellular_component biological_process uc029vhk.1 uc029vhk.2 uc029vhk.3 
ENSMUST00000059433.8 Pced1b ENSMUST00000059433.8 PC-esterase domain containing 1B, transcript variant 1 (from RefSeq NM_172293.5) ENSMUST00000059433.1 ENSMUST00000059433.2 ENSMUST00000059433.3 ENSMUST00000059433.4 ENSMUST00000059433.5 ENSMUST00000059433.6 ENSMUST00000059433.7 Fam113b NM_172293 PED1B_MOUSE Q5RK34 Q8BGX1 uc007xkt.1 uc007xkt.2 uc007xkt.3 uc007xkt.4 uc007xkt.5 Belongs to the PC-esterase family. molecular_function cellular_component biological_process uc007xkt.1 uc007xkt.2 uc007xkt.3 uc007xkt.4 uc007xkt.5 
ENSMUST00000059438.11 2310057M21Rik ENSMUST00000059438.11 RIKEN cDNA 2310057M21 gene, transcript variant 1 (from RefSeq NM_026655.4) ENSMUST00000059438.1 ENSMUST00000059438.10 ENSMUST00000059438.2 ENSMUST00000059438.3 ENSMUST00000059438.4 ENSMUST00000059438.5 ENSMUST00000059438.6 ENSMUST00000059438.7 ENSMUST00000059438.8 ENSMUST00000059438.9 NM_026655 PAAT_MOUSE Paat Q9D2Q3 uc009kbg.1 uc009kbg.2 uc009kbg.3 ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10. Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Homodimer. Interacts with ABCB7, ABCB8/MITOSUR and ABCB10. Cytoplasm Mitochondrion cellular_component biological_process identical protein binding uc009kbg.1 uc009kbg.2 uc009kbg.3 
ENSMUST00000059448.8 Sppl2c ENSMUST00000059448.8 signal peptide peptidase 2C, transcript variant 2 (from RefSeq NM_001082535.1) A2A6C4 ENSMUST00000059448.1 ENSMUST00000059448.2 ENSMUST00000059448.3 ENSMUST00000059448.4 ENSMUST00000059448.5 ENSMUST00000059448.6 ENSMUST00000059448.7 Imp5 NM_001082535 Q497R4 Q8BHP0 SPP2C_MOUSE Sppl2c uc007lwd.1 uc007lwd.2 uc007lwd.3 Sperm-specific intramembrane-cleaving aspartic protease (I- CLiP) that cleaves distinct tail-anchored proteins and SNARE proteins (PubMed:35960805, PubMed:30733280, PubMed:30733281). In elongated spermatids, modulates intracellular Ca(2+) homeostasis by controlling PLN abundance through proteolytic cleavage (PubMed:30733280). During spermatogenesis, processes SNARE proteins and impacts vesicular trafficking which supports compartmental reorganization in maturating spermatids and may play a role in formation of the acrosome (PubMed:30733281). In round spermatids, acts as a scaffold protein supporting FREY1 in IZUMO1 recruitment at the endoplasmic reticulum membrane and coordination of IZUMO1 complex assembly. Stabilizes FREY1 at the endoplasmic reticulum membrane through interaction. May recruit IZUMO1 interaction partners. [Isoform 2]: No difference in cleavage specificity compared to isoform 1. Interacts (via active sites) with FREY; the interaction stabilizes FREY1 protein and inhibits SPPL2C proteolytic activity. Endoplasmic reticulum membrane ulti-pass membrane protein ; Lumenal side Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A ; IsoId=A2A6C4-1; Sequence=Displayed; Name=2; Synonyms=B ; IsoId=A2A6C4-2; Sequence=VSP_030363, VSP_030364; [Isoform 1]: Highly expressed in testis where it is primarily localised in spermatids (at protein level). [Isoform 2]: Highly expressed in testis where it is primarily localised in spermatids (at protein level). The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP. Glycosylated. Knockout males produce normal-sized litters when bred with wild-type females (PubMed:35960805, PubMed:30733280). Mutants show a partial loss of elongated spermatids and reduced motility of mature spermatozoa, but preserved fertility. Matings of male and female mutant mice exhibit reduced litter sizes (PubMed:30733280). FREY1 and SPPL2C double knockout mice are normozoospermic infertile (PubMed:35960805). Belongs to the peptidase A22B family. Sequence=BAC36625.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC36625.1; Type=Frameshift; Evidence=; aspartic-type endopeptidase activity lysosomal membrane endoplasmic reticulum endoplasmic reticulum membrane proteolysis peptidase activity membrane integral component of membrane hydrolase activity Golgi-associated vesicle membrane membrane protein proteolysis aspartic endopeptidase activity, intramembrane cleaving protein homodimerization activity integral component of cytoplasmic side of endoplasmic reticulum membrane integral component of lumenal side of endoplasmic reticulum membrane membrane protein ectodomain proteolysis membrane protein intracellular domain proteolysis uc007lwd.1 uc007lwd.2 uc007lwd.3 
ENSMUST00000059449.7 Ces2b ENSMUST00000059449.7 carboxyesterase 2B (from RefSeq NM_198171.3) BC015286 Ces2b ENSMUST00000059449.1 ENSMUST00000059449.2 ENSMUST00000059449.3 ENSMUST00000059449.4 ENSMUST00000059449.5 ENSMUST00000059449.6 NM_198171 Q6PDB7 Q6PDB7_MOUSE uc009nbd.1 uc009nbd.2 uc009nbd.3 Belongs to the type-B carboxylesterase/lipase family. extracellular space biological_process hydrolase activity carboxylic ester hydrolase activity uc009nbd.1 uc009nbd.2 uc009nbd.3 
ENSMUST00000059452.6 Zfp831 ENSMUST00000059452.6 zinc finger protein 831 (from RefSeq NM_001099328.1) A2ADM8 A2ADM8_MOUSE ENSMUST00000059452.1 ENSMUST00000059452.2 ENSMUST00000059452.3 ENSMUST00000059452.4 ENSMUST00000059452.5 NM_001099328 Zfp831 uc008ofh.1 uc008ofh.2 uc008ofh.3 nucleic acid binding uc008ofh.1 uc008ofh.2 uc008ofh.3 
ENSMUST00000059458.5 Maml1 ENSMUST00000059458.5 mastermind like transcriptional coactivator 1, transcript variant 2 (from RefSeq NM_175334.3) ENSMUST00000059458.1 ENSMUST00000059458.2 ENSMUST00000059458.3 ENSMUST00000059458.4 Kiaa0200 MAML1_MOUSE Maml1 NM_175334 Q505D8 Q5SUC2 Q6PDK3 Q6T264 Q6ZQG5 Q8BIU5 Q8R3T0 uc007isd.1 uc007isd.2 uc007isd.3 uc007isd.4 uc007isd.5 Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8. Forms a complex with PRAG1, NOTCH1 and MAML1, in a MAML1-dependent manner (PubMed:25038227). Nucleus speckle Note=Nuclear, in a punctate manner. At E9.5, strongly expressed in the telencephalon, first branchial arch, forelimb buds and somites. By 10.5 dpc, continuously expressed in brain and spinal cord. Also expressed in first and second branchial arches and limb buds. By 11.5 dpc, expression in CNS is weak but increases in mesodermal tissues. At 14.5 dpc, detected in epithelial cells in trachea, esophagus and proximal and distal tubules of the developing lungs. The C-terminal region is required for transcriptional activation. Belongs to the mastermind family. Sequence=AAH94599.2; Type=Erroneous initiation; Evidence=; Sequence=BAC39618.1; Type=Erroneous initiation; Evidence=; Sequence=BAC97898.1; Type=Erroneous initiation; Evidence=; MAML1-RBP-Jkappa- ICN1 complex transcription coactivator activity nucleus nucleoplasm protein phosphorylation Notch signaling pathway positive regulation of transcription of Notch receptor target positive regulation of myotube differentiation nuclear speck protein kinase binding peptide antigen binding intracellular membrane-bounded organelle myoblast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of muscle cell differentiation atrioventricular node cell development uc007isd.1 uc007isd.2 uc007isd.3 uc007isd.4 uc007isd.5 
ENSMUST00000059466.3 Actrt1 ENSMUST00000059466.3 actin-related protein T1 (from RefSeq NM_028514.3) ACTT1_MOUSE ENSMUST00000059466.1 ENSMUST00000059466.2 NM_028514 Q9D9J3 uc009tbj.1 uc009tbj.2 Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Cytoplasm, cytoskeleton Cytoplasm Nucleus Note=Both detected in the nucleus and cytoplasm, localizes to the nucleus where it binds chromatin upon stimulation of the Hedgehog pathway. Belongs to the actin family. chromatin binding nucleus cytoplasm cytoskeleton regulation of transcription, DNA-templated regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated uc009tbj.1 uc009tbj.2 
ENSMUST00000059468.6 Ccnq ENSMUST00000059468.6 cyclin Q (from RefSeq NM_197989.1) CCNQ_MOUSE ENSMUST00000059468.1 ENSMUST00000059468.2 ENSMUST00000059468.3 ENSMUST00000059468.4 ENSMUST00000059468.5 Fam58a Fam58b NM_197989 Q8QZR8 uc007kjz.1 uc007kjz.2 Activating cyclin for the cyclin-associated kinase CDK10. Associates with CDK10 to promote its kinase activity. Belongs to the cyclin family. Cyclin-like FAM58 subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity protein binding nucleus regulation of transcription from RNA polymerase II promoter cyclin-dependent protein serine/threonine kinase regulator activity protein kinase activator activity activation of protein kinase activity positive regulation of MAPK cascade uc007kjz.1 uc007kjz.2 
ENSMUST00000059472.10 Mat2a ENSMUST00000059472.10 methionine adenosyltransferase 2A, transcript variant 1 (from RefSeq NM_145569.5) ENSMUST00000059472.1 ENSMUST00000059472.2 ENSMUST00000059472.3 ENSMUST00000059472.4 ENSMUST00000059472.5 ENSMUST00000059472.6 ENSMUST00000059472.7 ENSMUST00000059472.8 ENSMUST00000059472.9 Mat2a NM_145569 Q99J57 Q99J57_MOUSE uc009cip.1 uc009cip.2 Catalyzes the formation of S-adenosylmethionine from methionine and ATP. Reaction=ATP + H2O + L-methionine = diphosphate + phosphate + S- adenosyl-L-methionine; Xref=Rhea:RHEA:21080, ChEBI:CHEBI:15377, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789; EC=2.5.1.6; Evidence= Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence=; Note=Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate. ; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate. ; Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. Belongs to the AdoMet synthase family. nucleotide binding methionine adenosyltransferase activity ATP binding S-adenosylmethionine biosynthetic process one-carbon metabolic process transferase activity protein hexamerization identical protein binding metal ion binding methionine adenosyltransferase complex protein heterooligomerization uc009cip.1 uc009cip.2 
ENSMUST00000059482.6 Prss27 ENSMUST00000059482.6 serine protease 27 (from RefSeq NM_175440.4) ENSMUST00000059482.1 ENSMUST00000059482.2 ENSMUST00000059482.3 ENSMUST00000059482.4 ENSMUST00000059482.5 Mpn NM_175440 PRS27_MOUSE Q14A25 Q8BJR6 uc008aug.1 uc008aug.2 uc008aug.3 Secreted Belongs to the peptidase S1 family. serine-type endopeptidase activity extracellular region plasma membrane proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc008aug.1 uc008aug.2 uc008aug.3 
ENSMUST00000059498.12 Edem3 ENSMUST00000059498.12 ER degradation enhancer, mannosidase alpha-like 3, transcript variant 1 (from RefSeq NM_001039644.2) B2RS10 B9EHZ4 EDEM3_MOUSE ENSMUST00000059498.1 ENSMUST00000059498.10 ENSMUST00000059498.11 ENSMUST00000059498.2 ENSMUST00000059498.3 ENSMUST00000059498.4 ENSMUST00000059498.5 ENSMUST00000059498.6 ENSMUST00000059498.7 ENSMUST00000059498.8 ENSMUST00000059498.9 NM_001039644 Q2HXL6 Q6P9L0 uc007czc.1 uc007czc.2 uc007czc.3 uc007czc.4 Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD (PubMed:34143952). May have alpha 1,2-mannosidase activity. Reaction=4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- (1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = 4 beta-D-mannose + N(4)-(alpha-D-Man- (1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]- beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl- [protein] (N-glucan mannose isomer 5A1,2); Xref=Rhea:RHEA:56008, Rhea:RHEA-COMP:14356, Rhea:RHEA-COMP:14367, ChEBI:CHEBI:15377, ChEBI:CHEBI:28563, ChEBI:CHEBI:59087, ChEBI:CHEBI:139493; EC=3.2.1.113; Evidence=; Reaction=3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man- (1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D- Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man- (1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2); Xref=Rhea:RHEA:56028, Rhea:RHEA- COMP:14358, Rhea:RHEA-COMP:14367, ChEBI:CHEBI:15377, ChEBI:CHEBI:28563, ChEBI:CHEBI:59087, ChEBI:CHEBI:60628; EC=3.2.1.113; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum lumen Widely expressed. Expressed at higher level in liver, heart and kidney. Slightly increased by endoplasmic reticulum stress. Contains a protease-associated domain of unknown function. N-glycosylated. The knockout mice show largely skewed ratios of homozygous knockout pups versus heterozygous and wild-type pups. However knockout animals do not present with any obvious phenotype, only subtle changes, such as reduced weight of brains and body, as well as significantly increased abundance of circulating Man8GlcNAc2 and Man9GlcNAc2 in the plasma. Belongs to the glycosyl hydrolase 47 family. catalytic activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity calcium ion binding endoplasmic reticulum endoplasmic reticulum lumen protein glycosylation glycoprotein catabolic process response to unfolded protein membrane hydrolase activity proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding mannose trimming involved in glycoprotein ERAD pathway uc007czc.1 uc007czc.2 uc007czc.3 uc007czc.4 
ENSMUST00000059509.3 Ube2dnl1 ENSMUST00000059509.3 ubiquitin-conjugating enzyme E2D N-terminal like 1 (from RefSeq NM_001276396.1) A2AFH1 A2AFH1_MOUSE ENSMUST00000059509.1 ENSMUST00000059509.2 NM_001276396 Ube2dnl Ube2dnl1 uc009udy.1 uc009udy.2 Belongs to the ubiquitin-conjugating enzyme family. ubiquitin ligase complex nucleotide binding ATP binding ubiquitin-dependent protein catabolic process transferase activity ubiquitin protein ligase binding ubiquitin conjugating enzyme activity protein K48-linked ubiquitination uc009udy.1 uc009udy.2 
ENSMUST00000059524.7 Ahcyl ENSMUST00000059524.7 adenosylhomocysteinase like (from RefSeq NM_001304528.1) Ahcy ENSMUST00000059524.1 ENSMUST00000059524.2 ENSMUST00000059524.3 ENSMUST00000059524.4 ENSMUST00000059524.5 ENSMUST00000059524.6 NM_001304528 Q3TF14 Q3TF14_MOUSE uc056zce.1 uc056zce.2 uc056zce.3 Reaction=H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine; Xref=Rhea:RHEA:21708, ChEBI:CHEBI:15377, ChEBI:CHEBI:16335, ChEBI:CHEBI:57856, ChEBI:CHEBI:58199; EC=3.13.2.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21709; Evidence=; Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence= Note=Binds 1 NAD(+) per subunit. Amino-acid biosynthesis; L-homocysteine biosynthesis; L- homocysteine from S-adenosyl-L-homocysteine: step 1/1. Homotetramer. Interaction with AHCYL1. Belongs to the adenosylhomocysteinase family. adenosylhomocysteinase activity one-carbon metabolic process hydrolase activity uc056zce.1 uc056zce.2 uc056zce.3 
ENSMUST00000059534.5 Tas2r126 ENSMUST00000059534.5 taste receptor, type 2, member 126 (from RefSeq NM_207028.1) A0JNU7 ENSMUST00000059534.1 ENSMUST00000059534.2 ENSMUST00000059534.3 ENSMUST00000059534.4 NM_207028 P59532 Q7M704 T2R41_MOUSE Tas2r12 Tas2r26 Tas2r41 uc009brh.1 uc009brh.2 uc009brh.3 Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Membrane; Multi-pass membrane protein. Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli. Belongs to the G-protein coupled receptor T2R family. This protein was previously referred to as T2R26 or T2R12 but is now considered to be the ortholog of human TAS2R41. detection of chemical stimulus involved in sensory perception of bitter taste molecular_function G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane response to stimulus sensory perception of taste uc009brh.1 uc009brh.2 uc009brh.3 
ENSMUST00000059539.5 Nap1l5 ENSMUST00000059539.5 nucleosome assembly protein 1-like 5 (from RefSeq NM_021432.2) ENSMUST00000059539.1 ENSMUST00000059539.2 ENSMUST00000059539.3 ENSMUST00000059539.4 MNCb-0385 NM_021432 NP1L5_MOUSE Q9JJF0 uc009cdg.1 uc009cdg.2 uc009cdg.3 Nucleus Belongs to the nucleosome assembly protein (NAP) family. molecular_function cellular_component nucleus nucleosome assembly biological_process uc009cdg.1 uc009cdg.2 uc009cdg.3 
ENSMUST00000059555.15 Ube2q2 ENSMUST00000059555.15 ubiquitin-conjugating enzyme E2Q family member 2, transcript variant 1 (from RefSeq NM_180600.3) ENSMUST00000059555.1 ENSMUST00000059555.10 ENSMUST00000059555.11 ENSMUST00000059555.12 ENSMUST00000059555.13 ENSMUST00000059555.14 ENSMUST00000059555.2 ENSMUST00000059555.3 ENSMUST00000059555.4 ENSMUST00000059555.5 ENSMUST00000059555.6 ENSMUST00000059555.7 ENSMUST00000059555.8 ENSMUST00000059555.9 NM_180600 Q3UBX3 Q3V3A5 Q8BUN2 Q8BVX5 Q8K2Z8 UB2Q2_MOUSE uc009psb.1 uc009psb.2 uc009psb.3 uc009psb.4 uc009psb.5 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence=; Protein modification; protein ubiquitination. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2Z8-1; Sequence=Displayed; Name=2; IsoId=Q8K2Z8-2; Sequence=VSP_017300; Auto-ubiquitinated in vitro. Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding ubiquitin-protein transferase activity ATP binding cellular_component cytoplasm protein ubiquitination transferase activity ubiquitin conjugating enzyme activity protein K48-linked ubiquitination uc009psb.1 uc009psb.2 uc009psb.3 uc009psb.4 uc009psb.5 
ENSMUST00000059562.14 Lhfpl6 ENSMUST00000059562.14 LHFPL tetraspan subfamily member 6 (from RefSeq NM_175386.3) ENSMUST00000059562.1 ENSMUST00000059562.10 ENSMUST00000059562.11 ENSMUST00000059562.12 ENSMUST00000059562.13 ENSMUST00000059562.2 ENSMUST00000059562.3 ENSMUST00000059562.4 ENSMUST00000059562.5 ENSMUST00000059562.6 ENSMUST00000059562.7 ENSMUST00000059562.8 ENSMUST00000059562.9 LHPL6_MOUSE Lhfp Lhfpl6 NM_175386 Q3T9G7 Q3TWU2 Q8BM86 uc008pep.1 uc008pep.2 uc008pep.3 Membrane ; Multi-pass membrane protein Belongs to the LHFP family. molecular_function cellular_component biological_process membrane integral component of membrane uc008pep.1 uc008pep.2 uc008pep.3 
ENSMUST00000059566.11 Pacsin3 ENSMUST00000059566.11 protein kinase C and casein kinase substrate in neurons 3, transcript variant 2 (from RefSeq NM_001289677.1) ENSMUST00000059566.1 ENSMUST00000059566.10 ENSMUST00000059566.2 ENSMUST00000059566.3 ENSMUST00000059566.4 ENSMUST00000059566.5 ENSMUST00000059566.6 ENSMUST00000059566.7 ENSMUST00000059566.8 ENSMUST00000059566.9 NM_001289677 PACN3_MOUSE Q99JB8 Q9EQP9 uc008kvm.1 uc008kvm.2 uc008kvm.3 uc008kvm.4 Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity. Homodimer. May form heterooligomers with other PACSINs. Interacts (via SH3 domain) with DNM1, SYNJ1 and WASL. Interacts with TRPV4. Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Detected at the inner aspect of the plasma membrane in myotubes. Highly expressed in skeletal muscle, heart and lung; also detected in brain, kidney and uterus (at protein level). The F-BAR domain forms a coiled coil and mediates membrane- binding and membrane tubulation. Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). Belongs to the PACSIN family. protein binding phospholipid binding cytoplasm cytosol cytoskeleton plasma membrane endocytosis cytoskeleton organization cytoskeletal protein binding lipid binding membrane calcium channel inhibitor activity negative regulation of endocytosis positive regulation of membrane protein ectodomain proteolysis negative regulation of calcium ion transport plasma membrane tubulation trans-Golgi network uc008kvm.1 uc008kvm.2 uc008kvm.3 uc008kvm.4 
ENSMUST00000059571.7 Pcdhb19 ENSMUST00000059571.7 protocadherin beta 19 (from RefSeq NM_053144.3) ENSMUST00000059571.1 ENSMUST00000059571.2 ENSMUST00000059571.3 ENSMUST00000059571.4 ENSMUST00000059571.5 ENSMUST00000059571.6 NM_053144 Pcdhb19 Q91Y01 Q91Y01_MOUSE uc008eqe.1 uc008eqe.2 uc008eqe.3 calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eqe.1 uc008eqe.2 uc008eqe.3 
ENSMUST00000059579.12 Fam76b ENSMUST00000059579.12 family with sequence similarity 76, member B, transcript variant 1 (from RefSeq NM_176836.5) ENSMUST00000059579.1 ENSMUST00000059579.10 ENSMUST00000059579.11 ENSMUST00000059579.2 ENSMUST00000059579.3 ENSMUST00000059579.4 ENSMUST00000059579.5 ENSMUST00000059579.6 ENSMUST00000059579.7 ENSMUST00000059579.8 ENSMUST00000059579.9 FA76B_MOUSE NM_176836 Q3UMA6 Q80XP8 Q80YR1 Q8CI69 uc009oef.1 uc009oef.2 uc009oef.3 Nucleus speckle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80XP8-1; Sequence=Displayed; Name=2; IsoId=Q80XP8-2; Sequence=VSP_019774, VSP_019775, VSP_019776, VSP_019777; The polyhistidine repeat acts as a targeting signal to nuclear speckles. Belongs to the FAM76 family. nucleus nuclear speck uc009oef.1 uc009oef.2 uc009oef.3 
ENSMUST00000059580.11 Kmt5a ENSMUST00000059580.11 lysine methyltransferase 5A, transcript variant 1 (from RefSeq NM_030241.4) E9QNB8 E9QNB8_MOUSE ENSMUST00000059580.1 ENSMUST00000059580.10 ENSMUST00000059580.2 ENSMUST00000059580.3 ENSMUST00000059580.4 ENSMUST00000059580.5 ENSMUST00000059580.6 ENSMUST00000059580.7 ENSMUST00000059580.8 ENSMUST00000059580.9 Kmt5a NM_030241 Setd8 uc008zpu.1 uc008zpu.2 uc008zpu.3 uc008zpu.4 Reaction=L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60344, Rhea:RHEA-COMP:15554, Rhea:RHEA-COMP:15555, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.361; Evidence=; Reaction=L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:51736, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13053, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence=; Chromosome Nucleus methyltransferase activity transferase activity histone-lysine N-methyltransferase activity methylation histone lysine methylation uc008zpu.1 uc008zpu.2 uc008zpu.3 uc008zpu.4 
ENSMUST00000059588.8 Pdp2 ENSMUST00000059588.8 pyruvate dehydrogenase phosphatase catalytic subunit 2 (from RefSeq NM_001024606.2) 4833426J09Rik ENSMUST00000059588.1 ENSMUST00000059588.2 ENSMUST00000059588.3 ENSMUST00000059588.4 ENSMUST00000059588.5 ENSMUST00000059588.6 ENSMUST00000059588.7 NM_001024606 Pdp2 Q504M2 Q504M2_MOUSE uc009naw.1 uc009naw.2 uc009naw.3 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the PP2C family. catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity [pyruvate dehydrogenase (lipoamide)] phosphatase activity mitochondrion protein dephosphorylation hydrolase activity peptidyl-threonine dephosphorylation cation binding metal ion binding positive regulation of pyruvate dehydrogenase activity uc009naw.1 uc009naw.2 uc009naw.3 
ENSMUST00000059589.6 Rtn4r ENSMUST00000059589.6 reticulon 4 receptor (from RefSeq NM_022982.3) ENSMUST00000059589.1 ENSMUST00000059589.2 ENSMUST00000059589.3 ENSMUST00000059589.4 ENSMUST00000059589.5 NM_022982 Ngr1 Nogor Q80WQ1 Q99PI8 RTN4R_MOUSE uc007ymv.1 uc007ymv.2 uc007ymv.3 Receptor for RTN4, OMG and MAG (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:18411262, PubMed:22923615). Functions as a receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as a receptor for chondroitin sulfate proteoglycans (PubMed:22406547). Can also bind heparin (PubMed:22406547). Intracellular signaling cascades are triggered via the coreceptor NGFR (By similarity). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). Mediates axonal growth inhibition (By similarity). Mediates axonal growth inhibition and plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:22923615). Plays a role in postnatal brain development (PubMed:27339102). Required for normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG (PubMed:26335717). Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development (PubMed:20093372). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Homodimer (PubMed:29095159). Interacts with MAG (PubMed:12089450). Interacts with RTN4 (PubMed:15504325). Interacts with NGFR(PubMed:22923615). Interacts with LINGO1(PubMed:22923615). Interacts with KIAA0319L (By similarity). Interacts with OLFM1; this inhibits interaction with LINGO1 and NGFR (PubMed:22923615). Interacts with OMG (By similarity). Cell membrane ipid-anchor, GPI-anchor Membrane raft Cell projection, dendrite Cell projection, axon Perikaryon Note=Detected along dendrites and axons, close to synapses, but clearly excluded from synapses. Detected in embryonic hippocampus neurons (PubMed:22325200). Detected in brain (at protein level) (PubMed:15504325, PubMed:22406547). Detected in neurons in the neocortex, in hippocampus, dorsal thalamus, cerebellum granule cell layer and the mitral cell layer in the olfactory bulb (PubMed:15647357). Detected in brain, dorsal root ganglion and heart. N-glycosylated (PubMed:29095159). O-glycosylated. Contains terminal sialic acid groups on its glycan chains (By similarity). Mice are born at the expected Mendelian rate, are viable and fertile (PubMed:15504325, PubMed:15647357). They display subtle changes in exploratory behavior, manifest deficits in spatial working memory performance, and show impaired ability to stay on a rotarod (PubMed:15504325, PubMed:19052207). Compared to wild-type littermates, cultured hippocampus neurons from mutant mice display an increased number of excitatory synapses (PubMed:22325200). Effects on neurite outgrowth are controversial and may depend on the mouse strain, cell type, and the experimental conditions (PubMed:15504325, PubMed:15647357, PubMed:18411262, PubMed:19367338). Cultured neurons display impaired axon growth cone collapse in response to myelin, MAG and RTN4 (PubMed:15504325). Mutant cerebellar and dorsal root ganglion neurons show no decrease of the inhibition of neurite outgrowth by myelin or RTN4 (PubMed:15647357). Mutant cerebellar neurons display decreased inhibition of neurite outgrowth mediated by MAG and by cross- linking ganglioside GT1b (in vitro) (PubMed:18411262). Likewise, mutant sensory neurons show no decrease of the inhibition of neurite outgrowth by MAG (PubMed:19367338). Mutant mice have improved functional recovery and increased regeneration of rubrospinal and raphespinal fibers after spinal cord transection. Still, there is no regeneration of corticospinal fibers (PubMed:15504325, PubMed:15647357). Mice lacking both Rtn4r and Rtn4rl2 display no visible phenotype (PubMed:19367338). Sensory neurons from mice lacking both Rtn4r and Rtn4rl2 show moderately decreased inhibition of neurite outgrowth by MAG (PubMed:19367338). Mice with a triple gene disruption that lack Rtn4r, Rtn4rl1 and Rtn4rl2 have no visible phenotype, are healthy and viable (PubMed:22406547). Mice with a triple gene disruption that lack Rtn4r, Rtn4rl1 and Rtn4rl2 have normal brain size and grossly normal brain anatomy, but display disruption of medial brain structures, including an absence of the fasciola cinereum, corpus callosum agenesis and formation of bilateral Probst bundles indicative of the failure of callosally projecting neurons to extend across the midline (PubMed:27339102). Mice with a triple gene disruption of Rtn4r, Rtn4rl1 and Rtn4rl2 display impaired ability to stay on a rotarod and increased spontaneous locomotion (PubMed:27339102). These mice display an increased number of excitatory synapses in the apical dendritic regions of hippocampus neurons, an increase in the complexity of dendrite structure and increased total dendrite length (PubMed:22325200). One month after birth, mice with a triple gene disruption that lack Rtn4r, Rtn4rl1 and Rtn4rl2 show a significant reduction in the survival of motoneurons (PubMed:26335717). Compared to wild-type or single mutants, cerebellar granule cells from mice lacking Rtn4r, Rtn4rl1 and Rtn4rl2 show decreased myelin-mediated inhibition of neurite outgrowth, an inhibition that is strongly decreased on myelin deficient in Mag, Rtn4 and Omg (PubMed:22406547). Mice lacking both Rtn4r and Rtn4rl1 show increased axon regeneration after injury; the same effect is observed when Rtn4r, Rtn4rl1 and Rtn4rl2 are disrupted (PubMed:22406547). Combined disruption of Rtn4r, Rtn4rl1 and Ptprs further increases axon regeneration after injury (PubMed:22406547). Single gene disruption of Rtn4r, Rtn4rl1 and Rtn4rl2 and combined disruption of Rtn4r and Rtn4rl2 have no effect on axon regeneration (PubMed:22406547). Belongs to the Nogo receptor family. Name=Protein Spotlight; Note=Nerve regrowth: nipped by a no-go - Issue 69 of April 2006; URL="https://web.expasy.org/spotlight/back_issues/069"; protein binding endoplasmic reticulum plasma membrane integral component of plasma membrane cell surface receptor signaling pathway axonogenesis axon guidance heparin binding cell surface negative regulation of neuron projection development membrane corpus callosum development neuronal signal transduction axon dendrite growth cone negative regulation of axon extension anchored component of membrane anchored component of external side of plasma membrane positive regulation of Rho protein signal transduction chondroitin sulfate binding signaling receptor activity neuregulin receptor activity cell projection neuron projection neuronal cell body dendritic shaft perikaryon positive regulation of GTPase activity axonal growth cone macromolecular complex binding membrane raft Roundabout binding negative regulation of axon regeneration negative chemotaxis presynapse glutamatergic synapse ganglioside GM1 binding ganglioside GT1b binding uc007ymv.1 uc007ymv.2 uc007ymv.3 
ENSMUST00000059595.11 Prkca ENSMUST00000059595.11 protein kinase C, alpha (from RefSeq NM_011101.3) ENSMUST00000059595.1 ENSMUST00000059595.10 ENSMUST00000059595.2 ENSMUST00000059595.3 ENSMUST00000059595.4 ENSMUST00000059595.5 ENSMUST00000059595.6 ENSMUST00000059595.7 ENSMUST00000059595.8 ENSMUST00000059595.9 NM_011101 Prkca Q4VA93 Q4VA93_MOUSE uc011ygr.1 uc011ygr.2 uc011ygr.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence= Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain. ; Cytoplasm Membrane ; Peripheral membrane protein Mitochondrion membrane ; Peripheral membrane protein Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. nucleotide binding positive regulation of endothelial cell proliferation desmosome assembly protein kinase activity protein serine/threonine kinase activity protein kinase C activity ATP binding cytoplasm endoplasmic reticulum cytosol plasma membrane protein phosphorylation zinc ion binding positive regulation of endothelial cell migration kinase activity phosphorylation transferase activity enzyme binding positive regulation of cell migration positive regulation of lipopolysaccharide-mediated signaling pathway negative regulation of glial cell apoptotic process histone kinase activity (H3-T6 specific) histone H3-T6 phosphorylation intracellular signal transduction positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis positive regulation of cell adhesion positive regulation of mitotic cell cycle metal ion binding response to interleukin-1 regulation of platelet aggregation uc011ygr.1 uc011ygr.2 uc011ygr.3 
ENSMUST00000059596.8 Eid2 ENSMUST00000059596.8 EP300 interacting inhibitor of differentiation 2 (from RefSeq NM_198425.2) Cri2 EID2_MOUSE ENSMUST00000059596.1 ENSMUST00000059596.2 ENSMUST00000059596.3 ENSMUST00000059596.4 ENSMUST00000059596.5 ENSMUST00000059596.6 ENSMUST00000059596.7 Eid2 NM_198425 Q6X7S9 uc009fyc.1 uc009fyc.2 uc009fyc.3 Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3- dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex (By similarity). Heterodimer with EID2B. Interacts with the C-terminus of EP300. Interacts with HDAC1 and HDAC2. Interacts with SMAD2, SMAD4 and with the MH2 domain of SMAD3 (By similarity). Nucleus Expressed in heart, brain, kidney and pancreas. Not detected in placenta. First detected at 10.5 dpc with highest expression at 11.5 dpc. Expression decreases during later stages of development at 12.5 dpc and 14.5 dpc (at protein level). The N-terminal portion of EID2 is required for nuclear localization. negative regulation of transcription from RNA polymerase II promoter nucleus nucleoplasm transforming growth factor beta receptor complex assembly SMAD protein complex assembly multicellular organism development muscle organ development regulation of transforming growth factor beta receptor signaling pathway cell differentiation negative regulation of transforming growth factor beta receptor signaling pathway regulation of cell proliferation negative regulation of transcription, DNA-templated SMAD binding uc009fyc.1 uc009fyc.2 uc009fyc.3 
ENSMUST00000059598.3 Gm9776 ENSMUST00000059598.3 Gm9776 (from geneSymbol) AK141947 ENSMUST00000059598.1 ENSMUST00000059598.2 uc288pfb.1 uc288pfb.2 uc288pfb.1 uc288pfb.2 
ENSMUST00000059607.8 Teddm2 ENSMUST00000059607.8 transmembrane epididymal family member 2 (from RefSeq NM_178243.3) 5830403L16Rik ENSMUST00000059607.1 ENSMUST00000059607.2 ENSMUST00000059607.3 ENSMUST00000059607.4 ENSMUST00000059607.5 ENSMUST00000059607.6 ENSMUST00000059607.7 Me9 NM_178243 Q208S0 Q208S0_MOUSE Teddm2 uc007dam.1 uc007dam.2 Membrane ; Multi- pass membrane protein Belongs to the TMEM45 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007dam.1 uc007dam.2 
ENSMUST00000059619.3 Cdc42ep1 ENSMUST00000059619.3 CDC42 effector protein 1 (from RefSeq NM_027219.3) A0A0R4J0S1 A0A0R4J0S1_MOUSE Cdc42ep1 ENSMUST00000059619.1 ENSMUST00000059619.2 NM_027219 uc007wrl.1 uc007wrl.2 uc007wrl.3 Endomembrane system ; Peripheral membrane protein Belongs to the BORG/CEP family. regulation of cell shape positive regulation of pseudopodium assembly uc007wrl.1 uc007wrl.2 uc007wrl.3 
ENSMUST00000059637.8 Serpinb6d ENSMUST00000059637.8 serine (or cysteine) peptidase inhibitor, clade B, member 6d, transcript variant 1 (from RefSeq NM_001076790.2) ENSMUST00000059637.1 ENSMUST00000059637.2 ENSMUST00000059637.3 ENSMUST00000059637.4 ENSMUST00000059637.5 ENSMUST00000059637.6 ENSMUST00000059637.7 NM_001076790 OTTMUSG00000000712 Q3UWK8 Q3UWK8_MOUSE Serpinb6c Serpinb6d uc007qak.1 uc007qak.2 uc007qak.3 This gene is a member of the large Serpin gene family. Many members of this family act as protease inhibitors, and have a conserved structure including a reactive center loop (RCL) that can act as a bait for protease targets. Unlike some members of this large gene family, the protein encoded by this gene is an intracellular protein, and lacks an N-terminal signal peptide sequence. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jul 2014]. Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular space cytoplasm negative regulation of endopeptidase activity uc007qak.1 uc007qak.2 uc007qak.3 
ENSMUST00000059642.17 Psmd8 ENSMUST00000059642.17 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (from UniProt Q9CX56) AK153329 ENSMUST00000059642.1 ENSMUST00000059642.10 ENSMUST00000059642.11 ENSMUST00000059642.12 ENSMUST00000059642.13 ENSMUST00000059642.14 ENSMUST00000059642.15 ENSMUST00000059642.16 ENSMUST00000059642.2 ENSMUST00000059642.3 ENSMUST00000059642.4 ENSMUST00000059642.5 ENSMUST00000059642.6 ENSMUST00000059642.7 ENSMUST00000059642.8 ENSMUST00000059642.9 PSMD8_MOUSE Q9CX56 uc291npe.1 uc291npe.2 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD8, a base containing 6 ATPases and few additional components. Interacts with DDI2 (By similarity). Interacts with TASOR (PubMed:31112734). Expressed in the Sertoli cells of the testis. Belongs to the proteasome subunit S14 family. It is uncertain whether Met-1 or Met-65 is the initiator. Sequence=BAB32006.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; proteasome complex molecular_function cytosol proteasome regulatory particle proteolysis proteasome regulatory particle, lid subcomplex proteasome accessory complex proteasome-mediated ubiquitin-dependent protein catabolic process uc291npe.1 uc291npe.2 
ENSMUST00000059648.10 Slmapos2 ENSMUST00000059648.10 Slmapos2 (from geneSymbol) AK087762 ENSMUST00000059648.1 ENSMUST00000059648.2 ENSMUST00000059648.3 ENSMUST00000059648.4 ENSMUST00000059648.5 ENSMUST00000059648.6 ENSMUST00000059648.7 ENSMUST00000059648.8 ENSMUST00000059648.9 uc007ssp.1 uc007ssp.2 uc007ssp.1 uc007ssp.2 
ENSMUST00000059650.11 Npsr1 ENSMUST00000059650.11 neuropeptide S receptor 1 (from RefSeq NM_175678.3) ENSMUST00000059650.1 ENSMUST00000059650.10 ENSMUST00000059650.2 ENSMUST00000059650.3 ENSMUST00000059650.4 ENSMUST00000059650.5 ENSMUST00000059650.6 ENSMUST00000059650.7 ENSMUST00000059650.8 ENSMUST00000059650.9 Gpr154 NM_175678 NPSR1_MOUSE Pgr14 Q80T64 Q8BYA1 Q8BZP8 uc009oox.1 uc009oox.2 G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases. Cell membrane ; Multi-pass membrane protein Increased expression in lung after ovalbumin induction in a mouse model of ovalbumin-induced lung inflammation. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. Sequence=BAC30949.1; Type=Erroneous initiation; Evidence=; G-protein coupled receptor activity vasopressin receptor activity cytoplasm plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway neuropeptide receptor activity membrane integral component of membrane eating behavior positive regulation of release of sequestered calcium ion into cytosol righting reflex positive regulation of ERK1 and ERK2 cascade negative regulation of eating behavior negative regulation of defecation uc009oox.1 uc009oox.2 
ENSMUST00000059657.4 Gk2 ENSMUST00000059657.4 glycerol kinase 2 (from RefSeq NM_010294.2) ENSMUST00000059657.1 ENSMUST00000059657.2 ENSMUST00000059657.3 GLPK2_MOUSE Gk-rs2 Gkrs2 NM_010294 Q9WU65 uc008yfz.1 uc008yfz.2 uc008yfz.3 Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation (PubMed:28852571, PubMed:30662012). Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis.(PubMed:30662012). Can induce mitochondrial clustering through interactions with PLD6 and up- regulation of phosphatidic acid synthesis in the mitochondria (PubMed:28852571). Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216; EC=2.7.1.30; Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. Interacts with PLD6 (PubMed:28852571). Interacts with ARMC12 (PubMed:33536340). Mitochondrion outer membrane ; Single-pass type IV membrane protein Cytoplasm Note=In sperm the majority of the enzyme is bound to mitochondria. Testis-specific. Male mice are infertile due to dysfunctional spermatozoa, which exhibit unregulated ATP production, disordered mitochondrial sheath formation, abnormal mitochondrial morphology, and defective sperm tail (PubMed:30662012, PubMed:33536340). Spermatozoa cannot transit the uterotubal junction due to reduced motility leading to male infertility (PubMed:33536340). Spermatids exhibit abnormal arrangement of crescent-like mitochondria, which causes a disorganization of the mitochondrial sheath (PubMed:33536340). Belongs to the FGGY kinase family. nucleotide binding glycerol kinase activity ATP binding cytoplasm mitochondrion mitochondrial outer membrane carbohydrate metabolic process glycerol metabolic process glycerol-3-phosphate metabolic process triglyceride metabolic process membrane kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor glycerol catabolic process glycerol-3-phosphate biosynthetic process uc008yfz.1 uc008yfz.2 uc008yfz.3 
ENSMUST00000059662.8 Otulin ENSMUST00000059662.8 OTU deubiquitinase with linear linkage specificity, transcript variant 6 (from RefSeq NM_001416048.1) ENSMUST00000059662.1 ENSMUST00000059662.2 ENSMUST00000059662.3 ENSMUST00000059662.4 ENSMUST00000059662.5 ENSMUST00000059662.6 ENSMUST00000059662.7 Fam105b Gum NM_001416048 OTUL_MOUSE Otulin Q3UCV8 Q3UY59 Q5M8N1 Q8R027 uc007vjr.1 uc007vjr.2 uc007vjr.3 Deubiquitinase that specifically removes linear ('Met-1'- linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:27523608, PubMed:29950720). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (By similarity). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:29950720). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608, PubMed:29950720). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence= Interacts (via the PUB domain) with RNF31 (via the PIM motif); the interaction is direct (PubMed:23708998). Interacts with DVL2 (PubMed:23708998). Cytoplasm Enriched in a subset of endothelial cells near presumptive tips of vessels and vascular buds (at protein level). The specificity for linear polyubiquitin is given by the 'Glu- 16' residue in ubiquitin chain. The PIM (PUB-interaction motif) motif mediates interaction with the PUB domain of RNF31. Does not interact with other PUB domain- containing proteins. Phosphorylation at Tyr-56 prevents interaction with RNF31. Ubiquitinated. Acetylated. Phosphorylated. Phosphorylation at Tyr-56 prevents interaction with RNF31; dephosphorylation promotes interaction with RNF31 and the LUBAC complex. Embryonic lethality (PubMed:23708998, PubMed:27523608). Specific deletion in immune cells leads to acute systemic inflammation characterized by rapid weight loss, increased levels of pro-inflammatory cytokines in serum, neutrophilia with all the hallmarks of emergency granulopoiesis (PubMed:27523608). Specific deletion in T- or B-cells generates healthy mice with no overt inflammatory phenotypes (PubMed:27523608). In contrast, specific deletion in myeloid cells results in a strong inflammatory phenotype, characterized by chronic inflammation and autoimmunity, caused by sterile autoactivation of inflammatory pathways (PubMed:27523608). Belongs to the peptidase C65 family. Otulin subfamily. Sequence=AAH87945.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE22354.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; angiogenesis sprouting angiogenesis immune system process thiol-dependent ubiquitin-specific protease activity cytoplasm proteolysis peptidase activity cysteine-type peptidase activity regulation of tumor necrosis factor-mediated signaling pathway Wnt signaling pathway hydrolase activity negative regulation of NF-kappaB transcription factor activity thiol-dependent ubiquitinyl hydrolase activity innate immune response negative regulation of inflammatory response regulation of canonical Wnt signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway protein linear deubiquitination LUBAC complex uc007vjr.1 uc007vjr.2 uc007vjr.3 
ENSMUST00000059666.6 Saysd1 ENSMUST00000059666.6 SAYSVFN motif domain containing 1 (from RefSeq NM_026209.1) ENSMUST00000059666.1 ENSMUST00000059666.2 ENSMUST00000059666.3 ENSMUST00000059666.4 ENSMUST00000059666.5 NM_026209 Q8K190 SMDC1_MOUSE uc007siy.1 uc007siy.2 uc007siy.3 uc007siy.4 Cytoplasmic vesicle membrane ; Single-pass membrane protein molecular_function biological_process membrane integral component of membrane cytoplasmic vesicle membrane cytoplasmic vesicle intracellular membrane-bounded organelle uc007siy.1 uc007siy.2 uc007siy.3 uc007siy.4 
ENSMUST00000059667.9 Hpcal4 ENSMUST00000059667.9 hippocalcin-like 4 (from RefSeq NM_174998.4) ENSMUST00000059667.1 ENSMUST00000059667.2 ENSMUST00000059667.3 ENSMUST00000059667.4 ENSMUST00000059667.5 ENSMUST00000059667.6 ENSMUST00000059667.7 ENSMUST00000059667.8 HPCL4_MOUSE NM_174998 Q8BGZ1 uc008uox.1 uc008uox.2 uc008uox.3 May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Probably binds two or three calcium ions. Belongs to the recoverin family. calcium channel regulator activity calcium ion binding signal transduction protein C-terminus binding biological_process protein domain specific binding metal ion binding uc008uox.1 uc008uox.2 uc008uox.3 
ENSMUST00000059672.9 Pik3ap1 ENSMUST00000059672.9 phosphoinositide-3-kinase adaptor protein 1 (from RefSeq NM_031376.4) BCAP_MOUSE Bcap ENSMUST00000059672.1 ENSMUST00000059672.2 ENSMUST00000059672.3 ENSMUST00000059672.4 ENSMUST00000059672.5 ENSMUST00000059672.6 ENSMUST00000059672.7 ENSMUST00000059672.8 NM_031376 Q2KHL6 Q3TBW6 Q3TC39 Q3U5J3 Q8BN25 Q8C2Y4 Q9EQ32 uc008hlu.1 uc008hlu.2 uc008hlu.3 Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3- kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll- like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. Homooligomer (Probable). Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain); required for BCR- and TLR-mediated activation of phosphoinositide 3-kinase. Interacts (via polyproline C-terminal region) with ABI1 (via SH3 domain); the interaction promotes phosphorylation of PIK3AP1 by ABL1 (By similarity). May interact with MYD88 and TIRAP. Q9EQ32; P22366: Myd88; NbExp=2; IntAct=EBI-643949, EBI-525108; Q9EQ32; Q9EQ32: Pik3ap1; NbExp=3; IntAct=EBI-643949, EBI-643949; Q9EQ32; Q99JY1: Tirap; NbExp=2; IntAct=EBI-643949, EBI-6559589; Cytoplasm Cell membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=BCAP-L; IsoId=Q9EQ32-1; Sequence=Displayed; Name=2; Synonyms=BCAP-S; IsoId=Q9EQ32-2; Sequence=VSP_034241; Name=3; IsoId=Q9EQ32-3; Sequence=VSP_034242, VSP_034243; Predominantly expressed in spleen (at protein level). Expressed at lower levels in thymus, liver and lung. Expressed in B-cells, macrophages and natural killer (NK) cells. The DBB domain is required for dimerization. Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1 (By similarity). Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK. Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation. Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes. Mice lacking Pik3ap1 display altered B-cell maturation and impaired immune function. Pik3ap1 depletion has an opposite effect in NK cells by promoting their maturation. Mice lacking Pik3ap1 and Cd19 have severe defects in generation of immature and mature B-cells. Moreover, mice lacking Pik3ap1 display increased IL-10, Il-12 and TNF pro-inflammatory cytokine secretion upon activation of the Toll-like receptors TLR4, TLR7 and TLR9. receptor binding protein binding cytoplasm cytosol plasma membrane positive regulation of phosphatidylinositol 3-kinase signaling membrane negative regulation of toll-like receptor signaling pathway positive regulation of toll-like receptor signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor 7 signaling pathway toll-like receptor 9 signaling pathway phosphatidylinositol 3-kinase regulatory subunit binding identical protein binding regulation of inflammatory response nucleus regulation of I-kappaB kinase/NF-kappaB signaling regulation of MAPK cascade uc008hlu.1 uc008hlu.2 uc008hlu.3 
ENSMUST00000059676.5 Aqp12 ENSMUST00000059676.5 aquaporin 12, transcript variant 1 (from RefSeq NM_177587.2) AQP12_MOUSE ENSMUST00000059676.1 ENSMUST00000059676.2 ENSMUST00000059676.3 ENSMUST00000059676.4 NM_177587 Q3KNM4 Q8CHJ2 uc007cdc.1 uc007cdc.2 uc007cdc.3 Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. Membrane ; Multi-pass membrane protein Restricted to pancreatic acinar cells. Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily. cytoplasm channel activity membrane integral component of membrane transmembrane transport uc007cdc.1 uc007cdc.2 uc007cdc.3 
ENSMUST00000059680.7 Golph3 ENSMUST00000059680.7 golgi phosphoprotein 3 (from RefSeq NM_025673.2) A6BLP3 ENSMUST00000059680.1 ENSMUST00000059680.2 ENSMUST00000059680.3 ENSMUST00000059680.4 ENSMUST00000059680.5 ENSMUST00000059680.6 GOLP3_MOUSE Gpp34 NM_025673 Q99KY1 Q9CRA5 Q9D636 uc007vho.1 uc007vho.2 uc007vho.3 Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis (By similarity). Homodimer. Interacts with the coatomer complex. Interacts with MYO18A; the interaction is direct and may link Golgi membranes to the actin cytoskeleton. Interacts with GCNT1; may control its retention in the Golgi. Interacts with VPS35 (By similarity). [Isoform 2]: Golgi apparatus. Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein ; Cytoplasmic side Mitochondrion intermembrane space Cell membrane Endosome Note=Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CRA5-1; Sequence=Displayed; Name=2; Synonyms=GMx33alphaV, GPP34V; IsoId=Q9CRA5-2; Sequence=VSP_037833, VSP_037834; Expressed in all tissues tested including brain, heart, kidney, liver, lung, salivary gland, skeletal muscle, small intestine, spleen, stomach, skin and testis (at protein level). Phosphorylated. Belongs to the GOLPH3/VPS74 family. Sequence=BAB29486.1; Type=Frameshift; Evidence=; mitochondrion mitochondrial intermembrane space endosome Golgi apparatus trans-Golgi network cytosol plasma membrane retrograde vesicle-mediated transport, Golgi to ER Golgi organization cell proliferation lipid binding glycoprotein biosynthetic process protein secretion gene expression regulation of mitochondrion organization protein transport membrane cell migration enzyme binding lamellipodium assembly Golgi cisterna positive regulation of TOR signaling Golgi cisterna membrane Golgi to plasma membrane protein transport negative regulation of apoptotic process intracellular membrane-bounded organelle protein retention in Golgi apparatus Golgi vesicle budding positive regulation of protein secretion leukocyte tethering or rolling cell adhesion molecule production phosphatidylinositol-4-phosphate binding Golgi ribbon formation asymmetric Golgi ribbon formation uc007vho.1 uc007vho.2 uc007vho.3 
ENSMUST00000059692.4 Triml1 ENSMUST00000059692.4 tripartite motif family-like 1 (from RefSeq NM_177742.4) ENSMUST00000059692.1 ENSMUST00000059692.2 ENSMUST00000059692.3 NM_177742 Q8BVP1 TRIML_MOUSE uc009lnz.1 uc009lnz.2 Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development. Involved in progression of blastocyst stage and subsequent embryo development. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with USP5. Testis. Expressed from two-cell to blastocyst stage of embryo development. protein binding cellular_component multicellular organism development protein ubiquitination transferase activity metal ion binding uc009lnz.1 uc009lnz.2 
ENSMUST00000059699.9 C2cd4c ENSMUST00000059699.9 C2 calcium-dependent domain containing 4C, transcript variant 1 (from RefSeq NM_198614.3) C2C4C_MOUSE ENSMUST00000059699.1 ENSMUST00000059699.2 ENSMUST00000059699.3 ENSMUST00000059699.4 ENSMUST00000059699.5 ENSMUST00000059699.6 ENSMUST00000059699.7 ENSMUST00000059699.8 Fam148c NM_198614 Nlf3 Q5HZI2 Q8CDK0 uc007fzb.1 uc007fzb.2 uc007fzb.3 uc007fzb.4 Belongs to the C2CD4 family. cytosol biological_process uc007fzb.1 uc007fzb.2 uc007fzb.3 uc007fzb.4 
ENSMUST00000059707.3 Krt9 ENSMUST00000059707.3 keratin 9 (from RefSeq NM_201255.2) A2A4G3 ENSMUST00000059707.1 ENSMUST00000059707.2 K1C9_MOUSE K9 Krt1-9 Krt9 NM_201255 Q6RHW0 uc007lkn.1 uc007lkn.2 May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly (By similarity). Plays an essential role in the correct development of sperm. Heterotetramer of two type I and two type II keratins. Expressed in footpad epidermis and testis (at protein level). There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively). Belongs to the intermediate filament family. structural molecule activity intermediate filament spermatogenesis skin development keratin filament intermediate filament organization perinuclear region of cytoplasm uc007lkn.1 uc007lkn.2 
ENSMUST00000059718.6 Inhbe ENSMUST00000059718.6 inhibin beta-E (from RefSeq NM_008382.3) ENSMUST00000059718.1 ENSMUST00000059718.2 ENSMUST00000059718.3 ENSMUST00000059718.4 ENSMUST00000059718.5 INHBE_MOUSE NM_008382 O08717 Q91XH3 uc056yix.1 uc056yix.2 uc056yix.3 This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U96386.1, BC010404.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity). Secreted First expression in embryonic liver is detected at 17.5 dpc. Belongs to the TGF-beta family. cytokine activity transforming growth factor beta receptor binding hormone activity extracellular region extracellular space growth factor activity positive regulation of pathway-restricted SMAD protein phosphorylation regulation of apoptotic process regulation of MAPK cascade cell development SMAD protein signal transduction uc056yix.1 uc056yix.2 uc056yix.3 
ENSMUST00000059775.15 Tgif1 ENSMUST00000059775.15 TGFB-induced factor homeobox 1, transcript variant 2 (from RefSeq NM_009372.3) ENSMUST00000059775.1 ENSMUST00000059775.10 ENSMUST00000059775.11 ENSMUST00000059775.12 ENSMUST00000059775.13 ENSMUST00000059775.14 ENSMUST00000059775.2 ENSMUST00000059775.3 ENSMUST00000059775.4 ENSMUST00000059775.5 ENSMUST00000059775.6 ENSMUST00000059775.7 ENSMUST00000059775.8 ENSMUST00000059775.9 NM_009372 P70284 Q921F9 Q99JS3 TGIF1_MOUSE Tgif uc008dlp.1 uc008dlp.2 uc008dlp.3 uc008dlp.4 Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities (By similarity). Interacts with SMAD2 (By similarity). Interacts with CTBP, SMAD3 and HDAC1. Nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70284-1; Sequence=Displayed; Name=2; IsoId=P70284-2; Sequence=VSP_002297; Belongs to the TALE/TGIF homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding neural tube closure DNA binding chromatin binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated determination of left/right symmetry negative regulation of cell proliferation JUN kinase binding dorsal/ventral pattern formation regulation of gastrulation negative regulation of gene expression nodal signaling pathway positive regulation of neuron differentiation positive regulation of fibroblast proliferation negative regulation of retinoic acid receptor signaling pathway retina development in camera-type eye co-SMAD binding uc008dlp.1 uc008dlp.2 uc008dlp.3 uc008dlp.4 
ENSMUST00000059787.15 Dsg2 ENSMUST00000059787.15 desmoglein 2 (from RefSeq NM_007883.4) A2RRJ0 DSG2_MOUSE ENSMUST00000059787.1 ENSMUST00000059787.10 ENSMUST00000059787.11 ENSMUST00000059787.12 ENSMUST00000059787.13 ENSMUST00000059787.14 ENSMUST00000059787.2 ENSMUST00000059787.3 ENSMUST00000059787.4 ENSMUST00000059787.5 ENSMUST00000059787.6 ENSMUST00000059787.7 ENSMUST00000059787.8 ENSMUST00000059787.9 NM_007883 O55111 Q8K069 Q8R517 uc008ees.1 uc008ees.2 uc008ees.3 uc008ees.4 uc008ees.5 This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein die in utero. Mutant mice lacking a part of the extracellular adhesive domain of the encoded protein develop cardiac fibrosis and dilation. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB072269.1, BC131653.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Interacts with PKP2. Cell membrane ; Single-pass type I membrane protein Cell junction, desmosome Expressed in epidermis, heart, brain, spleen, lung, liver skeletal muscle, kidney and testis. Expressed in embryo at 7 to 17 dpc. Expressed uniformly in all 12.5 dpc epithelia, gradually becoming confined to the basal cell layers during. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Palmitoylated by ZDHHC5 at the plasma membrane. desmosome organization Purkinje myocyte development calcium ion binding plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules intercalated disc membrane integral component of membrane apical plasma membrane lateral plasma membrane cell junction desmosome response to progesterone intracellular membrane-bounded organelle metal ion binding cell adhesion molecule binding maternal process involved in female pregnancy bundle of His cell-Purkinje myocyte adhesion involved in cell communication regulation of heart rate by cardiac conduction cell-cell adhesion regulation of ventricular cardiac muscle cell action potential uc008ees.1 uc008ees.2 uc008ees.3 uc008ees.4 uc008ees.5 
ENSMUST00000059790.11 Pramel12 ENSMUST00000059790.11 PRAME like 12, transcript variant 1 (from RefSeq NM_172877.3) ENSMUST00000059790.1 ENSMUST00000059790.10 ENSMUST00000059790.2 ENSMUST00000059790.3 ENSMUST00000059790.4 ENSMUST00000059790.5 ENSMUST00000059790.6 ENSMUST00000059790.7 ENSMUST00000059790.8 ENSMUST00000059790.9 NM_172877 Pramef8 Pramel12 Q8CE24 Q8CE24_MOUSE uc008vqd.1 uc008vqd.2 uc008vqd.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vqd.1 uc008vqd.2 uc008vqd.3 
ENSMUST00000059794.4 Nhlh1 ENSMUST00000059794.4 nescient helix loop helix 1 (from RefSeq NM_010916.2) ENSMUST00000059794.1 ENSMUST00000059794.2 ENSMUST00000059794.3 HEN1_MOUSE Hen1 NM_010916 Q02576 uc007dpj.1 uc007dpj.2 uc007dpj.3 uc007dpj.4 May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. Efficient DNA binding requires dimerization with another bHLH protein. Nucleus RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus regulation of transcription from RNA polymerase II promoter multicellular organism development cell differentiation positive regulation of transcription from RNA polymerase II promoter protein dimerization activity uc007dpj.1 uc007dpj.2 uc007dpj.3 uc007dpj.4 
ENSMUST00000059805.6 Slc35d3 ENSMUST00000059805.6 solute carrier family 35, member D3 (from RefSeq NM_029529.3) ENSMUST00000059805.1 ENSMUST00000059805.2 ENSMUST00000059805.3 ENSMUST00000059805.4 ENSMUST00000059805.5 Frcl1 NM_029529 Q8BGF8 Q9CXD4 S35D3_MOUSE Slc35d3 uc007enk.1 uc007enk.2 uc007enk.3 Probable UDP-glucose transmembrane transporter involved in UDP-glucose transport from the cytosol to the lumen of synaptic vesicles (PubMed:34269178). It is involved in platelet dense granules maturation (PubMed:17062724, PubMed:22611153). Alternatively, could function as a molecular adapter enhancing the formation of the PI3KC3-C1/AIC/autophagy initiation complex to promote autophagy in dopaminergic neurons (PubMed:27171858). Could also regulate the plasma membrane localization of the D(1A) dopamine receptor/DRD1 and dopamine signaling (PubMed:24550737). Reaction=UDP-alpha-D-glucose(in) = UDP-alpha-D-glucose(out); Xref=Rhea:RHEA:76195, ChEBI:CHEBI:58885; Evidence=; Inhibited by proton uncouplers that directly abolish the proton electrochemical gradient. Could interact with ATG14, BECN1 and PIK3C3 that form the PI3KC3-C1/AIC/autophagy initiation complex; enhancing the formation of the AIC and promoting autophagy. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Active at early endosome membrane in the biosynthesis of mature platelet-dense granules. Expressed in brain (PubMed:17062724). Expressed in subsets of dopaminergic neurons (PubMed:27171858). Expressed in maturing megakaryocytes (PubMed:22611153). Mice lacking Slc35d3 display decreased concentrations of serotonin in platelet-dense granules and altered hemostasis (PubMed:17062724, PubMed:22611153). Mice also show a loss of dopaminergic neurons and exhibit metabolic syndrome and lowered energy expenditure (PubMed:24550737, PubMed:27171858). Belongs to the TPT transporter family. SLC35D subfamily. Sequence=BAB31067.1; Type=Frameshift; Evidence=; protein binding early endosome endoplasmic reticulum Golgi apparatus carbohydrate transport antiporter activity membrane integral component of membrane transmembrane transporter activity transmembrane transport positive regulation of protein exit from endoplasmic reticulum energy homeostasis uc007enk.1 uc007enk.2 uc007enk.3 
ENSMUST00000059808.5 H2bw2 ENSMUST00000059808.5 H2B.W histone 2 (from RefSeq NM_027067.2) 1700014N06Rik ENSMUST00000059808.1 ENSMUST00000059808.2 ENSMUST00000059808.3 ENSMUST00000059808.4 H2bfm H2bw2 NM_027067 Q9DAB5 Q9DAB5_MOUSE uc009ujf.1 uc009ujf.2 uc009ujf.3 uc009ujf.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family. [provided by RefSeq, Nov 2015]. ##Evidence-Data-START## Transcript is intronless :: AK005982.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 17261847 ##RefSeq-Attributes-END## Belongs to the histone H2B family. nucleosome DNA binding nucleus chromosome nucleosome assembly protein heterodimerization activity uc009ujf.1 uc009ujf.2 uc009ujf.3 uc009ujf.4 
ENSMUST00000059817.12 Zfp367 ENSMUST00000059817.12 zinc finger protein 367, transcript variant 1 (from RefSeq NM_175494.5) B1B191 B1B192 ENSMUST00000059817.1 ENSMUST00000059817.10 ENSMUST00000059817.11 ENSMUST00000059817.2 ENSMUST00000059817.3 ENSMUST00000059817.4 ENSMUST00000059817.5 ENSMUST00000059817.6 ENSMUST00000059817.7 ENSMUST00000059817.8 ENSMUST00000059817.9 NM_175494 Q0VDT2 Q8BH90 Q8BI44 Q8BI88 ZN367_MOUSE Zff29 Znf367 uc007qyj.1 uc007qyj.2 uc007qyj.3 Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Zff29B; IsoId=Q0VDT2-1; Sequence=Displayed; Name=2; IsoId=Q0VDT2-2; Sequence=VSP_024866; Expressed in bone marrow and ovary. Highly expressed in fetal erythroid tissue. Lower expression in yolk sac. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC39364.1; Type=Erroneous initiation; Evidence=; RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter metal ion binding uc007qyj.1 uc007qyj.2 uc007qyj.3 
ENSMUST00000059825.12 Crb1 ENSMUST00000059825.12 crumbs family member 1, photoreceptor morphogenesis associated (from RefSeq NM_133239.2) B7ZC63 CRUM1_MOUSE ENSMUST00000059825.1 ENSMUST00000059825.10 ENSMUST00000059825.11 ENSMUST00000059825.2 ENSMUST00000059825.3 ENSMUST00000059825.4 ENSMUST00000059825.5 ENSMUST00000059825.6 ENSMUST00000059825.7 ENSMUST00000059825.8 ENSMUST00000059825.9 NM_133239 Q6ST50 Q71JF2 Q8BGR4 Q8VHS2 uc007cwc.1 uc007cwc.2 uc007cwc.3 Plays a role in photoreceptor morphogenesis in the retina (PubMed:12915475). May maintain cell polarization and adhesion (PubMed:15316081). [Isoform 3]: May play a role in epidermal tissue morphogenesis (PubMed:14684155). May function in cell attachment for stratified epithelial organization (PubMed:14684155). Component of a complex composed of PALS1, CRB1 and EPB41L5 (By similarity). Within the complex, interacts (via intracellular domain) with PALS1 and EPB41L5 (via FERM domain) (By similarity). Forms a complex with MPP4 and PALS1 (PubMed:15316081). Interacts with MPDZ/MUPP1 and MPP4 (PubMed:15316081). [Isoform 1]: Apical cell membrane ; Single-pass type I membrane protein Secreted Cell projection, cilium, photoreceptor outer segment Photoreceptor inner segment [Isoform 3]: Secreted Cytoplasm Cell junction, focal adhesion Note=Found in the cytoplasmic area of undifferentiated keratinocytes and associated with the plasma membrane at the site of cell-cell contacts and focal adhesion upon keratinocytes differentiation. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8VHS2-1; Sequence=Displayed; Name=2; IsoId=Q8VHS2-2; Sequence=VSP_014731, VSP_014735, VSP_014736; Name=3; Synonyms=Crb1s ; IsoId=Q8VHS2-3; Sequence=VSP_014733, VSP_014734; Name=4; IsoId=Q8VHS2-4; Sequence=VSP_014730, VSP_014732, VSP_014733, VSP_014734; [Isoform 1]: Expressed in the kidney, lung, stomach and testis (PubMed:14684155). Expressed in the brain (PubMed:11744384, PubMed:14684155). Expressed in the retina of the eye (PubMed:11744384, PubMed:14684155, PubMed:26404741). Expressed in the outer nuclear layer, photoreceptor layer and inner nuclear layer of the retina (PubMed:11744384). Expressed in Mueller cell radial processes in the inner nuclear layer, in apical processes sclerad to the external limiting membrane, and in the subapical region, adjacent to the adherens junction of retinal photoreceptors (PubMed:12915475, PubMed:15316081). In the brain, expressed in the granular layer of the cerebellum, the hippocampal dentate gyrus, the olfactory bulbs, the subventricular region lining the telencephalic ventricles and the rostral migratory stream (PubMed:11744384). [Isoform 3]: Ubiquitously expressed. Primarily detected in the central nervous system at 10.5 dpc, in the ventral part of the neural tube including the ventral spinal cord, the ventral part of the mesencephalon, the mammillary and the hypothalamic regions, the optic area and the zona limitans intrathalamica (PubMed:11744384). Expressed by the V3 interneurons placed between the floor plate and the motorneurons all along the spinal cord axis (PubMed:11744384). In late embryogenesis, expressed mainly in ventral neural structures of the developing brain, including the mammillary, tuberalis regions of the hypothalamus and the preoptic area (PubMed:11744384). Starting from 12.5 dpc, also strongly expressed in the neural area that gives rise to the dorsal thalamus (PubMed:11744384). In the retina, expression starts at 11.5 dpc and is enhanced at 12.5, 14.5 and 16.5 dpc (PubMed:11744384). Expressed in the subapical region of the neuroepithelial layer of the retina at 17.5 dpc (PubMed:23001562). In postnatal stages, abundant expression in photoreceptors and also found in the inner nuclear layer and iris (PubMed:11744384). [Isoform 3]: Expression first detected at 14 dpc, expression is enhanced at 15 and 16 dpc during active proliferation of epidermal cells, decreases after birth, but is maintained in adult skin (PubMed:14684155). Detected in the skin basal cells at 16 dpc, it was observed in upper layers after birth (at protein level) (PubMed:14684155). Glycosylated. Note=Defects in Crb1 are a cause of focal retinal dysplasia and degeneration associated with a shortening of inner and outer segments. Affected mice produce a secreted truncated protein that lacks the single transmembrane and the intracellular domain, and develop irregularities at the outer limiting membrane and loss of photoreceptor cells. Belongs to the Crumbs protein family. photoreceptor inner segment calcium ion binding protein binding plasma membrane microvillus cell-cell adherens junction plasma membrane organization heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules membrane integral component of membrane macromolecular complex eye photoreceptor cell development establishment or maintenance of epithelial cell apical/basal polarity membrane organization uc007cwc.1 uc007cwc.2 uc007cwc.3 
ENSMUST00000059833.8 Fscb ENSMUST00000059833.8 fibrous sheath CABYR binding protein (from RefSeq NM_001163271.1) E9QJV1 E9QJV1_MOUSE ENSMUST00000059833.1 ENSMUST00000059833.2 ENSMUST00000059833.3 ENSMUST00000059833.4 ENSMUST00000059833.5 ENSMUST00000059833.6 ENSMUST00000059833.7 Fscb NM_001163271 uc011yme.1 uc011yme.2 uc011yme.3 uc011yme.1 uc011yme.2 uc011yme.3 
ENSMUST00000059844.13 Cnpy3 ENSMUST00000059844.13 canopy FGF signaling regulator 3, transcript variant 1 (from RefSeq NM_028065.4) CNPY3_MOUSE ENSMUST00000059844.1 ENSMUST00000059844.10 ENSMUST00000059844.11 ENSMUST00000059844.12 ENSMUST00000059844.2 ENSMUST00000059844.3 ENSMUST00000059844.4 ENSMUST00000059844.5 ENSMUST00000059844.6 ENSMUST00000059844.7 ENSMUST00000059844.8 ENSMUST00000059844.9 NM_028065 Prat4a Q571I0 Q8BUS5 Q8BUV5 Q8C0C5 Q9DAU1 Tnrc5 uc008cuf.1 uc008cuf.2 uc008cuf.3 uc008cuf.4 uc008cuf.5 This gene encodes a member of the canopy family of proteins. The encoded protein may play a role in the maturation of toll-like receptors. Homozygous knockout mice for this gene show reduced cell surface expression of toll-like receptors and an impaired immune response including reduced production of cytokines in a mouse model of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses. Interacts with HSP90B1; this interaction is disrupted in the presence of ATP. Interacts with TLR1, TLR2, TLR4 and TLR9. Strongest interaction with TLR4. Endoplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DAU1-1; Sequence=Displayed; Name=2; IsoId=Q9DAU1-2; Sequence=VSP_030134; The birth rate of knockout mice on a C57BL/6 background is very low (approximately 10% of pups). The animals appear normal, but their growth after birth is severely retarded. Half of them die by the end of the weaning period. Mutant mice have profoundly impaired T-helper type 1 lymphocyte (Th1)-mediated responses (PubMed:17998391). On a BALB/c background, under resting conditions, they show spastic or dystonic features and, during the open field test, they exhibit hyperactivity and anxiety. Their resting electroencephalography show enhanced activity in the fast beta frequency band (20-35 Hz). They do not show any apparent structural brain anomaly (PubMed:29394991). Belongs to the canopy family. immune system process receptor binding endoplasmic reticulum innate immune response uc008cuf.1 uc008cuf.2 uc008cuf.3 uc008cuf.4 uc008cuf.5 
ENSMUST00000059845.2 Sprr2h ENSMUST00000059845.2 small proline-rich protein 2H (from RefSeq NM_011474.4) ENSMUST00000059845.1 NM_011474 O70559 SPR2H_MOUSE uc008qdx.1 uc008qdx.2 uc008qdx.3 Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). Cytoplasm Expressed weakly in uterus. During early pregnancy, low expression detected in uterus at 1 dpc. Belongs to the cornifin (SPRR) family. cornified envelope cytoplasm epidermis development keratinocyte differentiation keratinization uc008qdx.1 uc008qdx.2 uc008qdx.3 
ENSMUST00000059849.15 Nelfb ENSMUST00000059849.15 negative elongation factor complex member B, transcript variant 1 (from RefSeq NM_021393.3) A0A0X1KG62 Cobra1 ENSMUST00000059849.1 ENSMUST00000059849.10 ENSMUST00000059849.11 ENSMUST00000059849.12 ENSMUST00000059849.13 ENSMUST00000059849.14 ENSMUST00000059849.2 ENSMUST00000059849.3 ENSMUST00000059849.4 ENSMUST00000059849.5 ENSMUST00000059849.6 ENSMUST00000059849.7 ENSMUST00000059849.8 ENSMUST00000059849.9 MNCb-5210 NELFB_MOUSE NM_021393 Q69ZP4 Q8C4Y3 Q99J41 Q9JJA5 uc008iqm.1 uc008iqm.2 uc008iqm.3 uc008iqm.4 uc008iqm.5 This gene encodes subunit B of a metazoan-specific, four-subunit protein complex that regulates promoter-proximal pausing of RNA polymerase II. RNA polymerase II pausing is thought to be important for coordination of gene transcription during embryonic development and stress responses. Consistently, disruption of this gene in mouse causes inner cell mass deficiency and embryonic lethality. In addition, this gene is required for maintenance of mouse embryonic stem cells by preventing expression of developmental genes. In adult mice, conditional deletion of this gene results in cardiomyopathy and impaired response to cardiac stress. Multiple protein isoforms are encoded through the use of a non-AUG (CUG) initiation codon and an alternative downstream AUG initiation codon. In addition, alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]. Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (Pol II) (PubMed:25773599). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). May be able to induce chromatin unfolding (By similarity). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (PubMed:19340312). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (PubMed:25773599). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (PubMed:24656816). The NELF complex is composed of NELFA, NELFB, NELFCD and NELFE; the N-terminus of NELFB binds to the NELFA:NELFCD subcomplex (By similarity). Binds RNA which may help to stabilize the NELF complex on nucleic acid (By similarity) Interacts with the first BRCT repeat of BRCA1 (By similarity). Interacts with KIAA1191 (By similarity). Isoform 1 and isoform 2 interact with NELFA, NELFCD and NELFE (PubMed:26010750). Nucleus Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=Q8C4Y3-1; Sequence=Displayed; Name=2; IsoId=Q8C4Y3-3; Sequence=VSP_059999; Isoform 1 is expressed in the kidney, liver, adipose and lung (PubMed:26010750). Isoform 2 is widely expressed (PubMed:26010750). Mice exhibit early embryonic lethality (PubMed:25773599, PubMed:19340312). Knockdown in embryonic stem cells (ESCs) leads to proliferation defects, increased differentiation, increased expression of development-associated genes and the dysregulation of genes involved in signaling and metabolic pathways (PubMed:25773599, PubMed:19340312). Mice exhibit cardiomyopathy, impaired response to cardiac stress and the reduced expression of metabolism-related genes in cardiomyocytes (PubMed:24656816). [Isoform 2]: Produced by alternative initiation at a CTG start codon. Belongs to the NELF-B family. Sequence=AAH04762.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AK080419; Type=Frameshift; Evidence=; Sequence=BAA95090.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; RNA binding protein binding nucleus nucleoplasm cytoplasm mitochondrial outer membrane cytosol cell proliferation NELF complex negative regulation of transcription elongation from RNA polymerase II promoter negative regulation of transcription, DNA-templated stem cell differentiation negative regulation of stem cell differentiation uc008iqm.1 uc008iqm.2 uc008iqm.3 uc008iqm.4 uc008iqm.5 
ENSMUST00000059851.14 Dcun1d3 ENSMUST00000059851.14 defective in cullin neddylation 1 domain containing 3, transcript variant 2 (from RefSeq NM_001163703.1) DCNL3_MOUSE Dcun1d3 ENSMUST00000059851.1 ENSMUST00000059851.10 ENSMUST00000059851.11 ENSMUST00000059851.12 ENSMUST00000059851.13 ENSMUST00000059851.2 ENSMUST00000059851.3 ENSMUST00000059851.4 ENSMUST00000059851.5 ENSMUST00000059851.6 ENSMUST00000059851.7 ENSMUST00000059851.8 ENSMUST00000059851.9 NM_001163703 Q8K0V2 SCCRO3 uc009jlz.1 uc009jlz.2 uc009jlz.3 uc009jlz.4 Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage. At the cell membrane, can promote and as well inhibit cullins neddylation. Part of a complex containing DCUN1D3, CUL3 and RBX1. Interacts (via the DCUN1 domain) with the unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5; these interactions promote the cullin neddylation and the identity of the cullin dictates the affinity of the interaction. Interacts preferentially with CUL3; this interaction triggers the relocalization of CUL3 to the cell membrane where CUL3 is neddylated. Interacts (via DCUN1 domain) with RBX1. May also interact with regulators or subunits of cullin-RING ligases such as RNF7, ELOB and DDB1; these interactions are bridged by cullins. Interacts (via DCUN1 domain) with CAND1; this interaction is bridged by cullins and strongly inhibits cullin neddylation. These CAND-cullin- DCNL complexes can only be neddylated in the presence of a substrate adapter. Interacts (via DCUN1 domain) with the N-terminally acetylated form of UBE2M and UBE2F. Cell membrane Cytoplasm Nucleus Cytoplasm, perinuclear region Note=After UVC treatment, the protein enters to the nucleus gradually. Cell membrane localization is essential for CUL3 neddylation. Highest levels of expression are in the testis (PubMed:26792857). Very low levels of expression in the heart, brain, skeletal muscle, kidney, liver, spleen, lung and ovary (PubMed:26792857). The DCUN1 domain, also known as PONY domain, mediates the interaction with different cullins. The DCUN1 domain mediates the interaction with the N-terminally acetylated NEDD8-conjugating E2s enzyme leading to the NEDD8 transfer from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes; the neddylation efficiency correlates with the DCUN1D5- cullin and DCUN1D5-E2 interaction affinities. This domain is also involved in CAND1-, cullins- and RBX1-binding. ubiquitin ligase complex molecular_function plasma membrane response to UV-C response to gamma radiation membrane negative regulation of cell growth ubiquitin conjugating enzyme binding ubiquitin-like protein binding positive regulation of apoptotic process protein neddylation perinuclear region of cytoplasm positive regulation of ubiquitin-protein transferase activity cullin family protein binding negative regulation of G1/S transition of mitotic cell cycle uc009jlz.1 uc009jlz.2 uc009jlz.3 uc009jlz.4 
ENSMUST00000059857.8 Rinl ENSMUST00000059857.8 Ras and Rab interactor-like, transcript variant 1 (from RefSeq NM_177158.5) ENSMUST00000059857.1 ENSMUST00000059857.2 ENSMUST00000059857.3 ENSMUST00000059857.4 ENSMUST00000059857.5 ENSMUST00000059857.6 ENSMUST00000059857.7 NM_177158 Q3TRU0 Q80UW3 Q811H9 Q8BUR6 Q8C0J1 RINL_MOUSE uc009fzw.1 uc009fzw.2 uc009fzw.3 uc009fzw.4 uc009fzw.5 uc009fzw.6 Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members. Interacts with RAB5A, RAB22A and MUSK. Cell projection, ruffle Cytoplasmic vesicle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80UW3-1; Sequence=Displayed; Name=2; IsoId=Q80UW3-2; Sequence=VSP_031892, VSP_031893; Detected in thymus and spleen (at protein level). Detected in lung, liver, kidney, spleen, thymus and skeletal muscle. Sequence=BAC38641.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE40363.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ruffle guanyl-nucleotide exchange factor activity GTPase activator activity protein binding endocytosis protein transport actin cytoskeleton cytoplasmic vesicle cell projection positive regulation of GTPase activity uc009fzw.1 uc009fzw.2 uc009fzw.3 uc009fzw.4 uc009fzw.5 uc009fzw.6 
ENSMUST00000059873.14 Treml4 ENSMUST00000059873.14 triggering receptor expressed on myeloid cells-like 4, transcript variant 2 (from RefSeq NM_172623.2) A6XA78 E9Q825 ENSMUST00000059873.1 ENSMUST00000059873.10 ENSMUST00000059873.11 ENSMUST00000059873.12 ENSMUST00000059873.13 ENSMUST00000059873.2 ENSMUST00000059873.3 ENSMUST00000059873.4 ENSMUST00000059873.5 ENSMUST00000059873.6 ENSMUST00000059873.7 ENSMUST00000059873.8 ENSMUST00000059873.9 NM_172623 Q3LRV9 Q3LRW0 TLT4 TRML4_MOUSE Treml3 uc008cxa.1 uc008cxa.2 uc008cxa.3 Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages (PubMed:25848864). Regulates TLR7 signaling by controlling ligand- induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes (PubMed:25848864). Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production (PubMed:25848864). Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus (PubMed:25848864). Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs) (PubMed:22210914, PubMed:19155473, PubMed:25848864). Does not bind nucleic acids (PubMed:25848864). May participate in antigen presentation (PubMed:22210914). Interacts with TYROBP/DAP12. Cell membrane ingle-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3LRV9-1; Sequence=Displayed; Name=2; IsoId=Q3LRV9-2; Sequence=VSP_044083; Name=3; IsoId=Q3LRV9-3; Sequence=VSP_044084; Predominantly expressed in spleen, with highest levels on selected populations of macrophages, including red pulp macrophages, and on subsets of dendritic cells (DC), mostly on CD8alpha(+) DC (at protein level) (PubMed:19155473, PubMed:22210914, PubMed:25848864). Also expressed on blood and spleen Ly6C(low) monocytes (at protein level) (PubMed:22210914). Not expressed on lymphocytes or granulocytes (at protein level) (PubMed:19155473, PubMed:22210914). Induced by synthetic TLR7 ligand gardiquimod (GRD) in cultured splenic macrophages. The cytoplasmic tail appears to be dispensable for TLR7- mediated signaling. No visible phenotype (PubMed:22210914). Mutant mice are born at the expected Mendelian frequency and are fertile and healthy (PubMed:22210914). In response to gardiquimod (GRD) or Resiquimod (R-848), 2 synthetic TLR7 ligands, levels of TNF, IL12B, IFNB1 and CXCL10 in splenic macrophages and in serum are severely reduced (PubMed:25848864). In response to CpG DNA, a TLR9 ligand, levels of TNF and IL12B but not IFNB1 and CXCL10 are severely reduced (PubMed:25848864). In response to infection with influenza virus (strain A/PuertoRico/8/34 (PR8)) the production of TNF, IL12B, IFNB1 and CXCL10 is severely impaired, the viral load is higher in the lungs, recovery after weight loss and survival are also impaired (PubMed:25848864). No defects in response to lipopolysaccharide (LPS) (PubMed:25848864). Reduced symptom severity in a mouse model for the autoimmune disease systemic lupus erythematosus (SLE) (PubMed:25848864). positive regulation of defense response to virus by host immune system process T cell antigen processing and presentation protein binding endoplasmic reticulum plasma membrane phagocytosis, engulfment protein localization cell surface membrane integral component of membrane positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 9 signaling pathway positive regulation of toll-like receptor 13 signaling pathway signaling receptor activity innate immune response regulation of innate immune response defense response to virus lysosomal membrane endosome membrane uc008cxa.1 uc008cxa.2 uc008cxa.3 
ENSMUST00000059880.7 Or7r1 ENSMUST00000059880.7 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A140T8J7) A0A140T8J7 A0A140T8J7_MOUSE ENSMUST00000059880.1 ENSMUST00000059880.2 ENSMUST00000059880.3 ENSMUST00000059880.4 ENSMUST00000059880.5 ENSMUST00000059880.6 Olfr1326 Or7r1 uc292pag.1 uc292pag.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292pag.1 uc292pag.2 
ENSMUST00000059886.12 Fcgbpl1 ENSMUST00000059886.12 Fc fragment of IgG binding protein like 1 (from RefSeq NM_001164655.1) 9530053A07Rik E9PVG8 E9PVG8_MOUSE ENSMUST00000059886.1 ENSMUST00000059886.10 ENSMUST00000059886.11 ENSMUST00000059886.2 ENSMUST00000059886.3 ENSMUST00000059886.4 ENSMUST00000059886.5 ENSMUST00000059886.6 ENSMUST00000059886.7 ENSMUST00000059886.8 ENSMUST00000059886.9 Fcgbpl1 NM_001164655 uc009fxx.1 uc009fxx.2 uc009fxx.3 molecular_function cellular_component biological_process uc009fxx.1 uc009fxx.2 uc009fxx.3 
ENSMUST00000059889.4 Adig ENSMUST00000059889.4 adipogenin (from RefSeq NM_145635.2) ADIG_MOUSE ENSMUST00000059889.1 ENSMUST00000059889.2 ENSMUST00000059889.3 NM_145635 Q8R400 Smaf1 uc008nqi.1 uc008nqi.2 Plays a role in stimulating adipocyte differentiation and development. Membrane ; Single-pass membrane protein Nucleus Selectively expressed in adipose tissue where it is particularly enriched in brown adipose tissue. In adipose tissue, expressed exclusively in adipocytes and not in the stromal-vascular cell population. Expressed at much lower levels in heart, stomach and muscle and barely detected in kidney and lung. Induced during adipose conversion of 3T3-L1 cells. Up- regulated in 3T3-L1 adipocytes by troglitazone which stimulates PPARG expression during differentiation. Down-regulated in 3T3-L1 adipocytes exposed to TNF-alpha and to retinoic acid. Belongs to the adipogenin family. molecular_function nucleus cytoplasm lipid particle spermatogenesis membrane integral component of membrane fat cell differentiation positive regulation of fat cell differentiation white fat cell differentiation brown fat cell differentiation uc008nqi.1 uc008nqi.2 
ENSMUST00000059891.3 Or6c76 ENSMUST00000059891.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRH6) BC120625 ENSMUST00000059891.1 ENSMUST00000059891.2 Olfr809 Or6c76 Q7TRH6 Q7TRH6_MOUSE uc007hqq.1 uc007hqq.2 uc007hqq.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hqq.1 uc007hqq.2 uc007hqq.3 
ENSMUST00000059893.8 Slc2a7 ENSMUST00000059893.8 solute carrier family 2 (facilitated glucose transporter), member 7, transcript variant 2 (from RefSeq NM_001368869.1) B1ARZ3 B1ARZ3_MOUSE ENSMUST00000059893.1 ENSMUST00000059893.2 ENSMUST00000059893.3 ENSMUST00000059893.4 ENSMUST00000059893.5 ENSMUST00000059893.6 ENSMUST00000059893.7 NM_001368869 Slc2a7 uc008vxl.1 uc008vxl.2 Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. plasma membrane membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008vxl.1 uc008vxl.2 
ENSMUST00000059899.3 Mmgt1 ENSMUST00000059899.3 membrane magnesium transporter 1 (from RefSeq NM_146234.4) A7UH87 EMC5_MOUSE ENSMUST00000059899.1 ENSMUST00000059899.2 Emc5 Mmgt1 NM_146234 Q8K273 Tmem32 uc009tgj.1 uc009tgj.2 uc009tgj.3 Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N- exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). May be involved Mg(2+) transport (PubMed:18057121). Component of the ER membrane protein complex (EMC). Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Abundant in heart muscle and kidney with lower levels in liver and brain and very little expression in intestine or colon. In kidney, highest levels in distal convoluted tubule. Up-regulated by low extracellular Mg(2+). Belongs to the membrane magnesium transporter (TC 1.A.67) family. Golgi membrane cytoplasm endosome early endosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane cation transport cobalt ion transport copper ion transport iron ion transport cobalt ion transmembrane transporter activity ferrous iron transmembrane transporter activity magnesium ion transmembrane transporter activity magnesium ion transport membrane integral component of membrane inorganic cation transmembrane transporter activity early endosome membrane iron ion transmembrane transport ER membrane protein complex cation transmembrane transport magnesium ion transmembrane transport uc009tgj.1 uc009tgj.2 uc009tgj.3 
ENSMUST00000059906.8 Prss33 ENSMUST00000059906.8 serine protease 33 (from RefSeq NM_001081399.2) ENSMUST00000059906.1 ENSMUST00000059906.2 ENSMUST00000059906.3 ENSMUST00000059906.4 ENSMUST00000059906.5 ENSMUST00000059906.6 ENSMUST00000059906.7 NM_001081399 PRS33_MOUSE Q3ZB43 Q80WM7 uc008att.1 uc008att.2 uc008att.3 uc008att.4 uc008att.5 Serine protease that has amidolytic activity, cleaving its substrates before Arg residues. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80WM7-1; Sequence=Displayed; Name=2; IsoId=Q80WM7-2; Sequence=VSP_027609; Widely expressed. Not glycosylated. Belongs to the peptidase S1 family. serine-type endopeptidase activity extracellular region extracellular space cytoplasm proteolysis peptidase activity serine-type peptidase activity hydrolase activity protein kinase C signaling uc008att.1 uc008att.2 uc008att.3 uc008att.4 uc008att.5 
ENSMUST00000059914.13 Virma ENSMUST00000059914.13 vir like m6A methyltransferase associated, transcript variant 2 (from RefSeq NM_001347055.1) A2AIV1 A2AIV2 ENSMUST00000059914.1 ENSMUST00000059914.10 ENSMUST00000059914.11 ENSMUST00000059914.12 ENSMUST00000059914.2 ENSMUST00000059914.3 ENSMUST00000059914.4 ENSMUST00000059914.5 ENSMUST00000059914.6 ENSMUST00000059914.7 ENSMUST00000059914.8 ENSMUST00000059914.9 Kiaa1429 NM_001347055 Q3TDQ3 Q3TRR9 Q3U1Z2 Q80TD6 Q8C758 Q8K151 Q9CSI3 VIR_MOUSE Virma uc008rzq.1 uc008rzq.2 uc008rzq.3 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA). Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:29535189, PubMed:29547716). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:29535189, PubMed:29547716). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29535189, PubMed:29547716). Interacts with WTAP (By similarity). Also a component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (By similarity). Interacts with NUDT21 and CPSF6 (By similarity). Nucleus speckle Nucleus, nucleoplasm Cytoplasm Note=Mainly nuclear with some fraction located in the cytoplasm (PubMed:29547716). ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus (PubMed:29547716). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AIV2-1; Sequence=Displayed; Name=2; IsoId=A2AIV2-2; Sequence=VSP_029022, VSP_029023; Belongs to the vir family. Sequence=AAH28830.1; Type=Erroneous initiation; Evidence=; nucleus nucleoplasm cytoplasm cytosol mRNA processing multicellular organism development RNA splicing nuclear body nuclear speck MIS complex mRNA methylation uc008rzq.1 uc008rzq.2 uc008rzq.3 
ENSMUST00000059930.3 Gm12185 ENSMUST00000059930.3 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. (from UniProt Q5NCB2) BC022776 ENSMUST00000059930.1 ENSMUST00000059930.2 Gm12185 Q5NCB2 Q5NCB2_MOUSE uc007ipk.1 uc007ipk.2 uc007ipk.3 uc007ipk.4 uc007ipk.5 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. GTPase activity GTP binding endoplasmic reticulum membrane defense response membrane cellular response to interferon-beta uc007ipk.1 uc007ipk.2 uc007ipk.3 uc007ipk.4 uc007ipk.5 
ENSMUST00000059937.5 Spata31e5 ENSMUST00000059937.5 spermatogenesis associated 31 subfamily E member 5 (from RefSeq NM_001013750.1) E9Q8J5 E9Q8J5_MOUSE ENSMUST00000059937.1 ENSMUST00000059937.2 ENSMUST00000059937.3 ENSMUST00000059937.4 Gm597 NM_001013750 uc007anb.1 uc007anb.2 uc007anb.3 Membrane ; Single- pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007anb.1 uc007anb.2 uc007anb.3 
ENSMUST00000059946.11 Henmt1 ENSMUST00000059946.11 HEN1 methyltransferase homolog 1 (Arabidopsis), transcript variant 1 (from RefSeq NM_025723.2) A2VCS5 ENSMUST00000059946.1 ENSMUST00000059946.10 ENSMUST00000059946.2 ENSMUST00000059946.3 ENSMUST00000059946.4 ENSMUST00000059946.5 ENSMUST00000059946.6 ENSMUST00000059946.7 ENSMUST00000059946.8 ENSMUST00000059946.9 HENMT_MOUSE NM_025723 Q8C3K8 Q8CAE2 uc008qzz.1 uc008qzz.2 uc008qzz.3 Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. Reaction=S-adenosyl-L-methionine + small RNA 3'-end nucleotide = H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide; Xref=Rhea:RHEA:37887, Rhea:RHEA-COMP:10415, Rhea:RHEA-COMP:10416, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74896, ChEBI:CHEBI:74898; EC=2.1.1.386; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Cytoplasm Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CAE2-1; Sequence=Displayed; Name=2; IsoId=Q8CAE2-2; Sequence=VSP_028012; Specifically expressed in testis. Belongs to the methyltransferase superfamily. HEN1 family. Sequence=BAC39480.1; Type=Frameshift; Evidence=; RNA methylation RNA binding nucleus cytoplasm cytosol methyltransferase activity O-methyltransferase activity RNA methyltransferase activity transferase activity production of siRNA involved in RNA interference gene silencing by RNA methylation piRNA metabolic process P granule metal ion binding uc008qzz.1 uc008qzz.2 uc008qzz.3 
ENSMUST00000059954.14 Pltp ENSMUST00000059954.14 phospholipid transfer protein, transcript variant 1 (from RefSeq NM_011125.3) ENSMUST00000059954.1 ENSMUST00000059954.10 ENSMUST00000059954.11 ENSMUST00000059954.12 ENSMUST00000059954.13 ENSMUST00000059954.2 ENSMUST00000059954.3 ENSMUST00000059954.4 ENSMUST00000059954.5 ENSMUST00000059954.6 ENSMUST00000059954.7 ENSMUST00000059954.8 ENSMUST00000059954.9 NM_011125 Pltp Q3UFS5 Q3UFS5_MOUSE uc008nwn.1 uc008nwn.2 uc008nwn.3 Secreted Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. lipid transporter activity phospholipid transporter activity extracellular space lipid metabolic process lipid transport lipid binding phosphatidylethanolamine binding phosphatidylcholine transporter activity positive regulation of cholesterol efflux phospholipid transport diacylglycerol binding phosphatidylcholine binding high-density lipoprotein particle high-density lipoprotein particle remodeling ceramide transport phosphatidic acid binding ceramide binding phosphatidylglycerol binding phosphatidylethanolamine transporter activity phosphatidic acid transporter activity uc008nwn.1 uc008nwn.2 uc008nwn.3 
ENSMUST00000059955.15 Yars2 ENSMUST00000059955.15 tyrosyl-tRNA synthetase 2 (mitochondrial), transcript variant 1 (from RefSeq NM_198246.2) ENSMUST00000059955.1 ENSMUST00000059955.10 ENSMUST00000059955.11 ENSMUST00000059955.12 ENSMUST00000059955.13 ENSMUST00000059955.14 ENSMUST00000059955.2 ENSMUST00000059955.3 ENSMUST00000059955.4 ENSMUST00000059955.5 ENSMUST00000059955.6 ENSMUST00000059955.7 ENSMUST00000059955.8 ENSMUST00000059955.9 NM_198246 Q6PAH7 Q8BYL4 SYYM_MOUSE uc007yig.1 uc007yig.2 uc007yig.3 uc007yig.4 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Reaction=ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L- tyrosyl-tRNA(Tyr); Xref=Rhea:RHEA:10220, Rhea:RHEA-COMP:9706, Rhea:RHEA-COMP:9707, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58315, ChEBI:CHEBI:78442, ChEBI:CHEBI:78536, ChEBI:CHEBI:456215; EC=6.1.1.1; Evidence=; Homodimer. Mitochondrion matrix Belongs to the class-I aminoacyl-tRNA synthetase family. tRNA binding nucleotide binding RNA binding aminoacyl-tRNA ligase activity tyrosine-tRNA ligase activity ATP binding cytoplasm mitochondrion mitochondrial matrix cytosol translation tRNA aminoacylation for protein translation tyrosyl-tRNA aminoacylation nuclear body ligase activity protein homodimerization activity tRNA aminoacylation mitochondrial tyrosyl-tRNA aminoacylation tyrosine binding uc007yig.1 uc007yig.2 uc007yig.3 uc007yig.4 
ENSMUST00000059967.2 4930402K13Rik ENSMUST00000059967.2 RIKEN cDNA 4930402K13 gene (from RefSeq NM_001270700.1) 4930402K13Rik B1AW18 B1AW18_MOUSE ENSMUST00000059967.1 NM_001270700 uc033joj.1 uc033joj.2 Belongs to the FAM47 family. molecular_function cellular_component biological_process uc033joj.1 uc033joj.2 
ENSMUST00000059970.9 Gulo ENSMUST00000059970.9 gulonolactone (L-) oxidase (from RefSeq NM_178747.3) ENSMUST00000059970.1 ENSMUST00000059970.2 ENSMUST00000059970.3 ENSMUST00000059970.4 ENSMUST00000059970.5 ENSMUST00000059970.6 ENSMUST00000059970.7 ENSMUST00000059970.8 GGLO_MOUSE NM_178747 P58710 Q8K152 uc007ujt.1 uc007ujt.2 uc007ujt.3 Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L- xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate. Reaction=L-gulono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate; Xref=Rhea:RHEA:32363, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17587, ChEBI:CHEBI:38290; EC=1.1.3.8; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Cofactor biosynthesis; L-ascorbate biosynthesis via UDP-alpha- D-glucuronate pathway; L-ascorbate from UDP-alpha-D-glucuronate: step 4/4. Microsome membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Highly expressed in liver. Belongs to the oxygen-dependent FAD-linked oxidoreductase family. D-arabinono-1,4-lactone oxidase activity endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor L-ascorbic acid biosynthetic process organelle membrane intracellular membrane-bounded organelle L-gulonolactone oxidase activity flavin adenine dinucleotide binding oxidation-reduction process FAD binding uc007ujt.1 uc007ujt.2 uc007ujt.3 
ENSMUST00000059975.8 Fam174a ENSMUST00000059975.8 family with sequence similarity 174, member A (from RefSeq NM_026321.4) ENSMUST00000059975.1 ENSMUST00000059975.2 ENSMUST00000059975.3 ENSMUST00000059975.4 ENSMUST00000059975.5 ENSMUST00000059975.6 ENSMUST00000059975.7 F174A_MOUSE NM_026321 Q3UF92 Q8CC46 Q8VDR1 Q9D238 Q9D3L0 Q9D6W5 Q9D6Z3 Tmem157 uc007cey.1 uc007cey.2 uc007cey.3 uc007cey.4 Membrane ; Single-pass type I membrane protein Belongs to the FAM174 family. Sequence=BAB26509.1; Type=Frameshift; Evidence=; Sequence=BAB26567.1; Type=Frameshift; Evidence=; Sequence=BAE28669.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc007cey.1 uc007cey.2 uc007cey.3 uc007cey.4 
ENSMUST00000059980.11 Rpl37a ENSMUST00000059980.11 ribosomal protein L37a (from RefSeq NM_009084.5) ENSMUST00000059980.1 ENSMUST00000059980.10 ENSMUST00000059980.2 ENSMUST00000059980.3 ENSMUST00000059980.4 ENSMUST00000059980.5 ENSMUST00000059980.6 ENSMUST00000059980.7 ENSMUST00000059980.8 ENSMUST00000059980.9 NM_009084 Q4VAF2 Q4VAF2_MOUSE Rpl37a uc007bkv.1 uc007bkv.2 uc007bkv.3 uc007bkv.4 Belongs to the eukaryotic ribosomal protein eL43 family. structural constituent of ribosome ribosome translation uc007bkv.1 uc007bkv.2 uc007bkv.3 uc007bkv.4 
ENSMUST00000059983.10 Vamp8 ENSMUST00000059983.10 vesicle-associated membrane protein 8 (from RefSeq NM_016794.3) A0A0R4J0R1 A0A0R4J0R1_MOUSE ENSMUST00000059983.1 ENSMUST00000059983.2 ENSMUST00000059983.3 ENSMUST00000059983.4 ENSMUST00000059983.5 ENSMUST00000059983.6 ENSMUST00000059983.7 ENSMUST00000059983.8 ENSMUST00000059983.9 NM_016794 Vamp8 uc009cin.1 uc009cin.2 uc009cin.3 uc009cin.4 Cell membrane ; Single-pass type IV membrane protein Early endosome membrane ; Single-pass type IV membrane protein Endosome membrane ; Single-pass type IV membrane protein Late endosome membrane ; Single-pass type IV membrane protein Lysosome membrane ; Single-pass type IV membrane protein Membrane ; Single-pass type IV membrane protein Zymogen granule membrane ; Single-pass type IV membrane protein Belongs to the synaptobrevin family. cytoplasm lysosomal membrane cytosol plasma membrane membrane integral component of membrane vesicle-mediated transport autophagosome docking chloride channel inhibitor activity secretory granule membrane SNARE complex late endosome membrane vesicle azurophil granule membrane viral entry into host cell perinuclear region of cytoplasm recycling endosome mucus secretion autophagosome maturation mucin granule regulation of protein localization to plasma membrane negative regulation of secretion by cell positive regulation of histamine secretion by mast cell uc009cin.1 uc009cin.2 uc009cin.3 uc009cin.4 
ENSMUST00000059986.3 Rnf182 ENSMUST00000059986.3 ring finger protein 182 (from RefSeq NM_183204.4) ENSMUST00000059986.1 ENSMUST00000059986.2 NM_183204 Q8C432 RN182_MOUSE uc007qgh.1 uc007qgh.2 uc007qgh.3 uc007qgh.4 E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with ATP6V0C. Membrane ; Multi- pass membrane protein Cytoplasm Expressed in the cortex, hippocampus, cerebellum and spinal cord, but not in the heart, liver, kidney or skeletal muscle. The RING-type zinc finger domain is required for E3 ligase activity. ubiquitin-protein transferase activity cytoplasm membrane integral component of membrane protein ubiquitination transferase activity metal ion binding uc007qgh.1 uc007qgh.2 uc007qgh.3 uc007qgh.4 
ENSMUST00000059997.10 Ccdc9b ENSMUST00000059997.10 coiled-coil domain containing 9B (from RefSeq NM_001001982.3) A0A8Q0K7A4 A0A8Q0K7A4_MOUSE Ccdc9b ENSMUST00000059997.1 ENSMUST00000059997.2 ENSMUST00000059997.3 ENSMUST00000059997.4 ENSMUST00000059997.5 ENSMUST00000059997.6 ENSMUST00000059997.7 ENSMUST00000059997.8 ENSMUST00000059997.9 NM_001001982 uc008lsn.1 uc008lsn.2 uc008lsn.3 uc008lsn.4 uc008lsn.1 uc008lsn.2 uc008lsn.3 uc008lsn.4 
ENSMUST00000060009.9 Exd1 ENSMUST00000060009.9 exonuclease 3'-5' domain containing 1, transcript variant 2 (from RefSeq NM_172857.3) ENSMUST00000060009.1 ENSMUST00000060009.2 ENSMUST00000060009.3 ENSMUST00000060009.4 ENSMUST00000060009.5 ENSMUST00000060009.6 ENSMUST00000060009.7 ENSMUST00000060009.8 EXD1_MOUSE Exdl1 NM_172857 Q8CDF7 uc008ltu.1 uc008ltu.2 uc008ltu.3 RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (PubMed:26669262). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity). Homodimer (By similarity). Component of the PET complex, at least composed of EXD1, PIWIL2, TDRD12 and piRNAs. Cytoplasm Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis. The 3'-5' exonuclease domain lacks the conserved Asp-Glu-Asp- Asp (DEDD) residues that coordinates divalent ions essential for exonuclease activity. Mice are viable and display normal fertility but show defective biogenesis of antisense piRNAs and activation of transposons. Reduced sequences generated by Piwil2 slicing, impaired biogenesis of Piwil4 piRNAs and derepressed LINE1 retrotransposons. Belongs to the EXD1 family. nucleic acid binding RNA binding cytoplasm nucleobase-containing compound metabolic process gene silencing by RNA piRNA metabolic process protein homodimerization activity P granule meiotic cell cycle nucleic acid phosphodiester bond hydrolysis PET complex 3'-5' exonuclease activity uc008ltu.1 uc008ltu.2 uc008ltu.3 
ENSMUST00000060010.3 Slc16a13 ENSMUST00000060010.3 solute carrier family 16 (monocarboxylic acid transporters), member 13 (from RefSeq NM_172371.3) ENSMUST00000060010.1 ENSMUST00000060010.2 MOT13_MOUSE Mct13 NM_172371 Q8CE94 Q8CEH6 Q8CF46 uc007jub.1 uc007jub.2 uc007jub.3 Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Golgi apparatus membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. Sequence=BAC25120.1; Type=Erroneous initiation; Evidence=; Golgi membrane Golgi apparatus plasma membrane integral component of plasma membrane monocarboxylic acid transmembrane transporter activity symporter activity monocarboxylic acid transport membrane integral component of membrane transmembrane transport uc007jub.1 uc007jub.2 uc007jub.3 
ENSMUST00000060013.4 Gm6377 ENSMUST00000060013.4 predicted gene 6377 (from RefSeq NM_001037917.2) EG622976 ENSMUST00000060013.1 ENSMUST00000060013.2 ENSMUST00000060013.3 Gm6377 NM_001037917 Q8BHV4 Q8BHV4_MOUSE uc009ucu.1 uc009ucu.2 uc009ucu.3 uc009ucu.4 molecular_function cellular_component biological_process uc009ucu.1 uc009ucu.2 uc009ucu.3 uc009ucu.4 
ENSMUST00000060041.7 Ccdc185 ENSMUST00000060041.7 coiled-coil domain containing 185 (from RefSeq NM_001033547.2) 4922505E12Rik Ccdc185 ENSMUST00000060041.1 ENSMUST00000060041.2 ENSMUST00000060041.3 ENSMUST00000060041.4 ENSMUST00000060041.5 ENSMUST00000060041.6 NM_001033547 Q3V118 Q3V118_MOUSE uc007dyj.1 uc007dyj.2 molecular_function cellular_component biological_process uc007dyj.1 uc007dyj.2 
ENSMUST00000060043.13 Wnk1 ENSMUST00000060043.13 WNK lysine deficient protein kinase 1, transcript variant 1 (from RefSeq NM_198703.3) A6H6V1 B2RRJ7 B7ZNJ4 ENSMUST00000060043.1 ENSMUST00000060043.10 ENSMUST00000060043.11 ENSMUST00000060043.12 ENSMUST00000060043.2 ENSMUST00000060043.3 ENSMUST00000060043.4 ENSMUST00000060043.5 ENSMUST00000060043.6 ENSMUST00000060043.7 ENSMUST00000060043.8 ENSMUST00000060043.9 Hsn2 NM_198703 P83741 Prkwnk1 Q3UZP3 Q6A083 Q6IFS6 Q6VYA0 WNK1_MOUSE Wnk1 uc009dmt.1 uc009dmt.2 uc009dmt.3 uc009dmt.4 Serine/threonine-protein kinase component of the WNK1- SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:12671053, PubMed:14610273). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (By similarity). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (By similarity). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (By similarity). Also acts as a regulator of angiogenesis in endothelial cells (PubMed:19644017). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (By similarity). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (By similarity). Acts as a negative regulator of autophagy (By similarity). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (By similarity). WNK1 may also play a role in actin cytoskeletal reorganization (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (PubMed:21317537, PubMed:23542070). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (By similarity). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (By similarity). [Isoform 7]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:21131289). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated in response to hyperosmotic stress: cell shrinkage promotes formation of a membraneless compartment that concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK (By similarity). Activation requires autophosphorylation of Ser-382 and, to a lower extent, Ser-378 (By similarity). Autophosphorylation and subsequent activation is inhibited by increases in intracellular ionic strength: Cl(-) potently inhibits WNK1 kinase activity via direct binding (By similarity). Also inhibited by K(+) ions (By similarity). Interacts with WNK3. Interacts with WNK4; inhibiting the activity of WNK4 (By similarity). Interacts with SGK1; promoting its activation. Associates with the mTORC2 complex (By similarity). Interacts with UVRAG (By similarity). [Isoform 7]: Interacts with isoform 1; inhibiting isoform 1 activity. Cytoplasm cleus Cytoplasm, cytoskeleton, spindle Note=Mediates formation and localizes to cytoplasmic membraneless compartment in response to hyperosmotic stress (By similarity). Also localizes to the nucleus (By similarity). Localizes to the mitotic spindle during mitosis (By similarity). Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=P83741-1; Sequence=Displayed; Name=2; Synonyms=Brain and spinal cord variant; IsoId=P83741-2; Sequence=VSP_040271; Name=3; Synonyms=Dorsal root ganglia and sciatic nerve variant, DRG and sciatic nerve variant; IsoId=P83741-3; Sequence=VSP_040272; Name=4; IsoId=P83741-4; Sequence=VSP_040273; Name=5; IsoId=P83741-5; Sequence=VSP_040274, VSP_040277; Name=6; IsoId=P83741-6; Sequence=VSP_040275, VSP_040276; Name=7; Synonyms=KS-WNK1 , Kidney-Specific ; IsoId=P83741-7; Sequence=VSP_058592, VSP_058593; Widely expressed in both adult and embryonic tissue, with highest levels observed in the testis and lower levels in heart, lung, kidney, placenta, brain and skeletal muscle (PubMed:11498583, PubMed:14514722, PubMed:12522152). Expressed in pancreatic duct (PubMed:21317537). Two isoforms are expressed in heart, a single shorter isoform in the kidney (PubMed:14514722). Locates to the distal convoluted tubule, the medullary collecting duct and the cortical collecting duct of the kidney (PubMed:14514722). [Isoform 2]: Restricted to the nervous system, expressed preferentially in sensory neurons than in motor neurons and in general more abundant in axons than in cell bodies (at protein level) (PubMed:18521183). In the DRG, predominantly expressed in the satellite cells that envelop sensory neurons, but low expression also observed in the cell bodies of neurons (at protein level) (PubMed:18521183). In the sciatic nerve, expressed in the Schwann cells that surround axons and in a mosaic distribution of axons (at protein level) (PubMed:18521183). In the spinal cord, expressed in superficial layers (LI and LII), as well as in the fibers of the Lissauer tract (at protein level) (PubMed:18521183). Also detected in the axon fibers of dorsolateral funiculus and lateral funiculus (at protein level) (PubMed:18521183). [Isoform 3]: Restricted to the nervous system, expressed preferentially in sensory neurons than in motor neurons and in general more abundant in axons than in cell bodies (at protein level) (PubMed:18521183). In the DRG, predominantly expressed in the satellite cells that envelop sensory neurons, but low expression also observed in the cell bodies of neurons (at protein level) (PubMed:18521183). In the sciatic nerve, expressed in the Schwann cells that surround axons and in a mosaic distribution of axons (at protein level) (PubMed:18521183). In the spinal cord, expressed in superficial layers (LI and LII), as well as in the fibers of the Lissauer tract (at protein level) (PubMed:18521183). Also detected in the axon fibers of dorsolateral funiculus and lateral funiculus (at protein level) (PubMed:18521183). The RFXV motifs mediate recognition with downstream kinases OXSR1/OSR1 and STK39/SPAK. Disordered regions undergo liquid-liquid phase separation (LLPS) for the formation of a cytoplasmic membraneless compartment that concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK. Autophosphorylated at Ser-378 and Ser-382, promoting its activity (By similarity). Autophosphorylation at Ser-382 is inhibited by intracellular calcium (By similarity). Phosphorylation at Thr-58 increases ability to activate SGK1 (By similarity). Ubiquitinated by the BCR(KLHL3) complex, leading to its degradation (By similarity). Also ubiquitinated by the BCR(KLHL2) complex (By similarity). May be O-glycosylated. Embryonic lethality before day 13 of gestation (PubMed:14610273, PubMed:19644017). Embryos show cardiovascular developmental defects: the developing heart has smaller chambers and reduced myocardial trabeculation at E10.5 (PubMed:19644017). Yolk sac vessels in the E10.5 null mutant fail to remodel into a network of large and small vessels and embryonic vessels show defective angiogenesis that involves both arteries and veins (PubMed:19644017). Hypomorphic mice display a significant decrease in blood pressure (PubMed:14610273). Conditional deletion in endothelial cells leads to cardiovascular developmental defects, leading to embryonic lethality (PubMed:19644017). [Isoform 6]: May be due to intron retention. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins. It is uncertain whether Met-1 or Met-214 is the initiator. HSN2 was originally thought to be an intronless gene lying within a WNK1 gene intron. It has been shown to be a nervous system- specific exon of WNK1 included in isoform 2 and isoform 3 (PubMed:18521183). Sequence=AAI46010.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=AAI46012.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=BAD32213.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=DAA04493.1; Type=Erroneous gene model prediction; Note=Includes 3' and 3' intronic sequences.; Evidence=; nucleotide binding magnesium ion binding regulation of sodium ion transport positive regulation of systemic arterial blood pressure protein kinase activity protein serine/threonine kinase activity protein kinase inhibitor activity protein binding ATP binding cytoplasm cytosol protein phosphorylation negative regulation of protein kinase activity ion transport negative regulation of sodium ion transport positive regulation of T cell chemotaxis negative regulation of phosphatase activity membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation chloride channel inhibitor activity potassium channel inhibitor activity protein kinase binding phosphatase binding signal transduction by trans-phosphorylation protein serine/threonine kinase inhibitor activity protein kinase activator activity activation of protein kinase activity positive regulation of ion transmembrane transporter activity negative regulation of cell-cell adhesion mediated by integrin negative regulation of kinase activity negative regulation of heterotypic cell-cell adhesion negative regulation of GTPase activity intracellular signal transduction chemokine (C-C motif) ligand 21 signaling pathway protein autophosphorylation regulation of cellular process ion homeostasis T cell receptor signaling pathway cellular response to calcium ion negative regulation of protein serine/threonine kinase activity negative regulation of pancreatic juice secretion positive regulation of canonical Wnt signaling pathway lymphocyte migration into lymph node negative regulation of leukocyte cell-cell adhesion positive regulation of potassium ion import cellular response to chemokine positive regulation of sodium ion transmembrane transporter activity uc009dmt.1 uc009dmt.2 uc009dmt.3 uc009dmt.4 
ENSMUST00000060049.8 Haus3 ENSMUST00000060049.8 HAUS augmin-like complex, subunit 3 (from RefSeq NM_146159.1) ENSMUST00000060049.1 ENSMUST00000060049.2 ENSMUST00000060049.3 ENSMUST00000060049.4 ENSMUST00000060049.5 ENSMUST00000060049.6 ENSMUST00000060049.7 HAUS3_MOUSE NM_146159 Q3TSW5 Q8BQL2 Q8CIH1 Q8QZX2 uc008xbv.1 uc008xbv.2 uc008xbv.3 uc008xbv.4 uc008xbv.5 uc008xbv.6 Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly (By similarity). Interacts with EML3 (phosphorylated at 'Thr-882') (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8QZX2-1; Sequence=Displayed; Name=2; IsoId=Q8QZX2-2; Sequence=VSP_027887; Belongs to the HAUS3 family. Sequence=BAE36560.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleoplasm cytoplasm mitochondrion centrosome microtubule organizing center spindle cytoskeleton microtubule cell cycle centrosome cycle microtubule cytoskeleton intercellular bridge spindle assembly cell division HAUS complex mitotic spindle uc008xbv.1 uc008xbv.2 uc008xbv.3 uc008xbv.4 uc008xbv.5 uc008xbv.6 
ENSMUST00000060050.6 Fam110d ENSMUST00000060050.6 family with sequence similarity 110, member D (from RefSeq NM_001099296.2) ENSMUST00000060050.1 ENSMUST00000060050.2 ENSMUST00000060050.3 ENSMUST00000060050.4 ENSMUST00000060050.5 F110D_MOUSE Fam110d Grrp1 NM_001099296 Q80X91 uc008veo.1 uc008veo.2 Belongs to the FAM110 family. molecular_function cellular_component biological_process uc008veo.1 uc008veo.2 
ENSMUST00000060057.2 Sowahd ENSMUST00000060057.2 sosondowah ankyrin repeat domain family member D (from RefSeq NM_173779.4) Ankrd58 ENSMUST00000060057.1 NM_173779 Q8BY98 SWAHD_MOUSE uc009syb.1 uc009syb.2 Belongs to the SOWAH family. molecular_function cellular_component biological_process uc009syb.1 uc009syb.2 
ENSMUST00000060061.11 Pygo2 ENSMUST00000060061.11 pygopus 2, transcript variant 1 (from RefSeq NM_001293768.1) ENSMUST00000060061.1 ENSMUST00000060061.10 ENSMUST00000060061.2 ENSMUST00000060061.3 ENSMUST00000060061.4 ENSMUST00000060061.5 ENSMUST00000060061.6 ENSMUST00000060061.7 ENSMUST00000060061.8 ENSMUST00000060061.9 NM_001293768 Pygo2 Q80V76 Q80V76_MOUSE uc008pzo.1 uc008pzo.2 uc008pzo.3 uc008pzo.4 uc008pzo.5 Involved in signal transduction through the Wnt pathway. Nucleus in utero embryonic development kidney development lens development in camera-type eye chromatin binding protein binding nucleus spermatid development spermatid nucleus differentiation brain development post-embryonic development mammary gland development regulation of mammary gland epithelial cell proliferation histone acetyltransferase regulator activity regulation of histone acetylation positive regulation of chromatin binding histone binding metal ion binding developmental growth regulation of histone H3-K4 methylation palate development canonical Wnt signaling pathway beta-catenin-TCF complex uc008pzo.1 uc008pzo.2 uc008pzo.3 uc008pzo.4 uc008pzo.5 
ENSMUST00000060062.5 Actrt2 ENSMUST00000060062.5 actin-related protein T2 (from RefSeq NM_028513.3) ACTT2_MOUSE Arpm2 ENSMUST00000060062.1 ENSMUST00000060062.2 ENSMUST00000060062.3 ENSMUST00000060062.4 NM_028513 Q9D9L5 uc008wca.1 uc008wca.2 uc008wca.3 uc008wca.4 Cytoplasm, cytoskeleton Belongs to the actin family. molecular_function cytoplasm cytoskeleton biological_process uc008wca.1 uc008wca.2 uc008wca.3 uc008wca.4 
ENSMUST00000060077.7 Cpox ENSMUST00000060077.7 coproporphyrinogen oxidase (from RefSeq NM_007757.2) Cpo ENSMUST00000060077.1 ENSMUST00000060077.2 ENSMUST00000060077.3 ENSMUST00000060077.4 ENSMUST00000060077.5 ENSMUST00000060077.6 HEM6_MOUSE NM_007757 P36552 Q7TQ36 Q8VD08 uc007zoa.1 uc007zoa.2 uc007zoa.3 uc007zoa.4 uc007zoa.5 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX (By similarity). Reaction=coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX; Xref=Rhea:RHEA:18257, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:57307, ChEBI:CHEBI:57309; EC=1.3.3.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18258; Evidence=; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. Homodimer. Mitochondrion intermembrane space Expressed in erythroid cells. Expressed in liver (PubMed:8407975). Acetylation of Lys-360 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the aerobic coproporphyrinogen-III oxidase family. Sequence=AAH17680.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAA03840.1; Type=Frameshift; Evidence=; coproporphyrinogen oxidase activity structural constituent of eye lens sodium:potassium-exchanging ATPase activity cytoplasm mitochondrion mitochondrial inner membrane mitochondrial intermembrane space cytosol porphyrin-containing compound biosynthetic process protoporphyrinogen IX biosynthetic process heme biosynthetic process potassium ion transport sodium ion transport response to inorganic substance response to iron ion establishment or maintenance of transmembrane electrochemical gradient response to lead ion membrane oxidoreductase activity response to insecticide identical protein binding protein homodimerization activity response to arsenic-containing substance response to methylmercury oxidation-reduction process uc007zoa.1 uc007zoa.2 uc007zoa.3 uc007zoa.4 uc007zoa.5 
ENSMUST00000060092.13 Upf2 ENSMUST00000060092.13 UPF2 regulator of nonsense transcripts homolog (yeast) (from RefSeq NM_001081132.1) A2AT37 ENSMUST00000060092.1 ENSMUST00000060092.10 ENSMUST00000060092.11 ENSMUST00000060092.12 ENSMUST00000060092.2 ENSMUST00000060092.3 ENSMUST00000060092.4 ENSMUST00000060092.5 ENSMUST00000060092.6 ENSMUST00000060092.7 ENSMUST00000060092.8 ENSMUST00000060092.9 NM_001081132 RENT2 RENT2_MOUSE Upf2 uc008igc.1 uc008igc.2 Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. Found in a post-splicing messenger ribonucleoprotein (mRNP) complex (By similarity). Associates with the exon junction complex (EJC) (By similarity). Interacts with SMG1, EST1A, UPF3A, UPF3B, EIF4A1 and EIF1 (By similarity). Interacts with UPF1; interaction is promoted by TDRD6 (PubMed:27149095). Interacts with DDX4 (PubMed:27149095). Cytoplasm, perinuclear region Cytoplasm Localized in male germ cells. Weakly expressed in neonatal testes and expression increases during the development of spermatocytes and spermatids, in the late meiotic and postmeiotic stages of spermatogenesis. Knockout adult liver results in hepatosteatosis and disruption of liver homeostasis. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay liver development RNA binding nucleus cytoplasm cytosol polysome response to unfolded protein animal organ regeneration exon-exon junction complex cytoplasmic ribonucleoprotein granule telomeric DNA binding perinuclear region of cytoplasm uc008igc.1 uc008igc.2 
ENSMUST00000060095.15 Tmtc1 ENSMUST00000060095.15 transmembrane and tetratricopeptide repeat containing 1, transcript variant 1 (from RefSeq NM_198967.6) E9QM13 ENSMUST00000060095.1 ENSMUST00000060095.10 ENSMUST00000060095.11 ENSMUST00000060095.12 ENSMUST00000060095.13 ENSMUST00000060095.14 ENSMUST00000060095.2 ENSMUST00000060095.3 ENSMUST00000060095.4 ENSMUST00000060095.5 ENSMUST00000060095.6 ENSMUST00000060095.7 ENSMUST00000060095.8 ENSMUST00000060095.9 NM_198967 Q3UV71 Q8BQV5 TMTC1_MOUSE Tmtc1 uc009etj.1 uc009etj.2 uc009etj.3 uc009etj.4 Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3. Reaction=a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3- O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+); Xref=Rhea:RHEA:17377, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:13546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:137321; EC=2.4.1.109; Evidence=; Reaction=a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+); Xref=Rhea:RHEA:53396, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13547, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:137323; EC=2.4.1.109; Evidence=; Protein modification; protein glycosylation. May interact with FAM168B. Membrane ; Multi-pass membrane protein Endoplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UV71-1; Sequence=Displayed; Name=2; IsoId=Q3UV71-2; Sequence=VSP_023618; Belongs to the TMTC family. Sequence=BAC32703.1; Type=Frameshift; Evidence=; mannosyltransferase activity dolichyl-phosphate-mannose-protein mannosyltransferase activity mitochondrion endoplasmic reticulum RNA processing protein glycosylation membrane integral component of membrane transferase activity protein O-linked mannosylation uc009etj.1 uc009etj.2 uc009etj.3 uc009etj.4 
ENSMUST00000060100.3 Ccdc96 ENSMUST00000060100.3 coiled-coil domain containing 96 (from RefSeq NM_025725.3) CCD96_MOUSE ENSMUST00000060100.1 ENSMUST00000060100.2 NM_025725 Q9CR92 uc008xeq.1 uc008xeq.2 uc008xeq.3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome molecular_function cellular_component cytoplasm microtubule organizing center cytoskeleton biological_process uc008xeq.1 uc008xeq.2 uc008xeq.3 
ENSMUST00000060108.7 1810030O07Rik ENSMUST00000060108.7 RIKEN cDNA 1810030O07 gene (from RefSeq NM_175141.6) CX038_MOUSE ENSMUST00000060108.1 ENSMUST00000060108.2 ENSMUST00000060108.3 ENSMUST00000060108.4 ENSMUST00000060108.5 ENSMUST00000060108.6 NM_175141 Q3TFM9 Q8C5K5 Q8CF12 uc009sqy.1 uc009sqy.2 uc009sqy.3 uc009sqy.4 uc009sqy.5 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C5K5-1; Sequence=Displayed; Name=2; IsoId=Q8C5K5-2; Sequence=VSP_014623; molecular_function cellular_component biological_process uc009sqy.1 uc009sqy.2 uc009sqy.3 uc009sqy.4 uc009sqy.5 
ENSMUST00000060125.7 Scn4b ENSMUST00000060125.7 sodium channel, type IV, beta (from RefSeq NM_001013390.3) ENSMUST00000060125.1 ENSMUST00000060125.2 ENSMUST00000060125.3 ENSMUST00000060125.4 ENSMUST00000060125.5 ENSMUST00000060125.6 Gm1471 NM_001013390 Q7M729 SCN4B_MOUSE uc009pfh.1 uc009pfh.2 uc009pfh.3 Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity). The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit (SCN2A) regulated by one or more beta subunits (SCN1B, SCN2B, SCN3B and SCN4B). SCN1B and SCN3B are non- covalently associated with SCN2A. SCN2B and SCN4B are disulfide-linked to SCN2A (By similarity). Cell membrane ; Single-pass type I membrane protein Contains an interchain disulfide bond with SCN2A. N-glycosylated. Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family. voltage-gated sodium channel complex voltage-gated ion channel activity voltage-gated sodium channel activity sodium channel activity plasma membrane ion transport sodium ion transport positive regulation of sodium ion transport intercalated disc membrane integral component of membrane sodium channel regulator activity intrinsic component of plasma membrane regulation of ion transmembrane transport sodium ion transmembrane transport ion channel binding cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization cardiac muscle cell action potential involved in contraction voltage-gated sodium channel activity involved in cardiac muscle cell action potential membrane depolarization during cardiac muscle cell action potential AV node cell action potential regulation of heart rate by cardiac conduction regulation of sodium ion transmembrane transporter activity uc009pfh.1 uc009pfh.2 uc009pfh.3 
ENSMUST00000060128.7 Cldn23 ENSMUST00000060128.7 claudin 23 (from RefSeq NM_027998.4) CLD23_MOUSE ENSMUST00000060128.1 ENSMUST00000060128.2 ENSMUST00000060128.3 ENSMUST00000060128.4 ENSMUST00000060128.5 ENSMUST00000060128.6 NM_027998 Q9D7D7 uc009llc.1 uc009llc.2 uc009llc.3 uc009llc.4 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and the protein encoded by this gene is 77% identical to the human homolog. [provided by RefSeq, Aug 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Belongs to the claudin family. molecular_function structural molecule activity cellular_component plasma membrane bicellular tight junction biological_process membrane integral component of membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding uc009llc.1 uc009llc.2 uc009llc.3 uc009llc.4 
ENSMUST00000060133.8 Spata33 ENSMUST00000060133.8 spermatogenesis associated 33 (from RefSeq NM_177279.4) ENSMUST00000060133.1 ENSMUST00000060133.2 ENSMUST00000060133.3 ENSMUST00000060133.4 ENSMUST00000060133.5 ENSMUST00000060133.6 ENSMUST00000060133.7 NM_177279 Q8C624 SPT33_MOUSE uc009nul.1 uc009nul.2 uc009nul.3 Plays an important role in sperm motility and male fertility (PubMed:34446558). Required for sperm midpiece flexibility and for the localization of sperm calcineurin to the mitochondria (PubMed:34446558). Promotes mitophagy as well as acts as an autophagy mediator in male germline cells (PubMed:33087875). Links damaged mitochondria to autophagosomes via its binding to the outer mitochondrial membrane protein VDAC2, as well as to key autophagy machinery component ATG16L1 (PubMed:33087875). Interacts (via PQIIIT motif) with PPP3R2 and PPP3CC (PubMed:34446558). Interacts with VDAC2 (PubMed:34446558, PubMed:33087875). Interacts with ATG16L1 (via WD repeats) (PubMed:33087875). Interacts with PPP3R1, PPP3CA and PPP3CB (By similarity). Cytoplasm, cytosol Nucleus Cytoplasm Mitochondrion Predominantly expressed in the testis (at protein level) (PubMed:23844118, PubMed:34446558, PubMed:33087875). Expressed in the sperm midpiece (at protein level) (PubMed:34446558, PubMed:33087875). Mainly expressed in the postpartum and adult testis. Predominantly expressed in the spermatocytes, as well as spermatogonia and round spermatids (at protein level). Expression increases during the first wave of the spermatogenesis. Mice exhibit reduced sperm motility because of an inflexible midpiece, leading to impaired male fertility (PubMed:34446558). Spata33 knockout in Sertoli cells and spermatogenic cells suppresses mitophagy (PubMed:33087875). molecular_function nucleus cytoplasm cytosol biological_process uc009nul.1 uc009nul.2 uc009nul.3 
ENSMUST00000060148.6 Hivep1 ENSMUST00000060148.6 human immunodeficiency virus type I enhancer binding protein 1 (from RefSeq NM_007772.2) ENSMUST00000060148.1 ENSMUST00000060148.2 ENSMUST00000060148.3 ENSMUST00000060148.4 ENSMUST00000060148.5 F8VPM9 F8VPM9_MOUSE Hivep1 NM_007772 uc007qfk.1 uc007qfk.2 Nucleus negative regulation of transcription from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding nucleus nucleoplasm mitochondrion zinc ion binding nuclear body BMP signaling pathway positive regulation of transcription from RNA polymerase II promoter metal ion binding uc007qfk.1 uc007qfk.2 
ENSMUST00000060167.6 Nrn1l ENSMUST00000060167.6 neuritin 1-like, transcript variant 1 (from RefSeq NM_175024.4) Cpg15-2 ENSMUST00000060167.1 ENSMUST00000060167.2 ENSMUST00000060167.3 ENSMUST00000060167.4 ENSMUST00000060167.5 NM_175024 NRN1L_MOUSE Q8BN06 Q8C4W3 uc009nem.1 uc009nem.2 uc009nem.3 Cell membrane ; Lipid-anchor, GPI- anchor Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C4W3-1; Sequence=Displayed; Name=2; IsoId=Q8C4W3-2; Sequence=VSP_031481; Belongs to the neuritin family. extracellular space plasma membrane nervous system development membrane axon anchored component of membrane protein homodimerization activity anchored component of plasma membrane protein heterodimerization activity neuron projection extension uc009nem.1 uc009nem.2 uc009nem.3 
ENSMUST00000060173.9 Samd10 ENSMUST00000060173.9 sterile alpha motif domain containing 10, transcript variant 1 (from RefSeq NM_172676.3) ENSMUST00000060173.1 ENSMUST00000060173.2 ENSMUST00000060173.3 ENSMUST00000060173.4 ENSMUST00000060173.5 ENSMUST00000060173.6 ENSMUST00000060173.7 ENSMUST00000060173.8 NM_172676 Q7TST3 SAM10_MOUSE Samd10 uc008omw.1 uc008omw.2 uc008omw.3 uc008omw.4 molecular_function cellular_component biological_process uc008omw.1 uc008omw.2 uc008omw.3 uc008omw.4 
ENSMUST00000060174.6 P2ry6 ENSMUST00000060174.6 pyrimidinergic receptor P2Y, G-protein coupled, 6 (from RefSeq NM_183168.2) ENSMUST00000060174.1 ENSMUST00000060174.2 ENSMUST00000060174.3 ENSMUST00000060174.4 ENSMUST00000060174.5 NM_183168 P2RY6_MOUSE Q9ERK9 uc009inw.1 uc009inw.2 uc009inw.3 uc009inw.4 Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. ADP receptor activity G-protein coupled receptor activity plasma membrane phagocytosis signal transduction G-protein coupled receptor signaling pathway positive regulation of smooth muscle cell migration membrane integral component of membrane basolateral plasma membrane apical plasma membrane pyrimidine nucleotide binding transepithelial chloride transport positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity positive regulation of inositol trisphosphate biosynthetic process G-protein coupled purinergic nucleotide receptor signaling pathway G-protein coupled purinergic nucleotide receptor activity UDP-activated nucleotide receptor activity UTP-activated nucleotide receptor activity positive regulation of ERK1 and ERK2 cascade cellular response to prostaglandin E stimulus cellular response to organic cyclic compound cellular response to purine-containing compound positive regulation of vascular smooth muscle cell proliferation uc009inw.1 uc009inw.2 uc009inw.3 uc009inw.4 
ENSMUST00000060175.8 Mosmo ENSMUST00000060175.8 modulator of smoothened, transcript variant 1 (from RefSeq NM_001164580.2) Atthog ENSMUST00000060175.1 ENSMUST00000060175.2 ENSMUST00000060175.3 ENSMUST00000060175.4 ENSMUST00000060175.5 ENSMUST00000060175.6 ENSMUST00000060175.7 MOSMO_MOUSE Mosmo NM_001164580 Q3TS22 Q8C784 Q8K0V1 uc009jmx.1 uc009jmx.2 uc009jmx.3 uc009jmx.4 Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane (PubMed:29290584). Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation (PubMed:29290584). Cell projection, cilium membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C784-1; Sequence=Displayed; Name=2; IsoId=Q8C784-2; Sequence=VSP_022277; Expressed in the ventral neural tube at 11.5 dpc. Sequence=AAH30336.1; Type=Erroneous initiation; Evidence=; molecular_function Golgi apparatus plasma membrane membrane integral component of membrane cell differentiation regulation of protein stability cell projection regulation of neuron differentiation negative regulation of smoothened signaling pathway ciliary membrane uc009jmx.1 uc009jmx.2 uc009jmx.3 uc009jmx.4 
ENSMUST00000060185.3 Fndc9 ENSMUST00000060185.3 fibronectin type III domain containing 9 (from RefSeq NM_177075.4) ENSMUST00000060185.1 ENSMUST00000060185.2 FNDC9_MOUSE NM_177075 Q8BJN4 uc007ioe.1 uc007ioe.2 uc007ioe.3 Membrane ; Single-pass membrane protein Encoded in intron of the gene CYFIP2 (opposite strand). molecular_function cellular_component biological_process membrane integral component of membrane uc007ioe.1 uc007ioe.2 uc007ioe.3 
ENSMUST00000060187.15 Or51e2 ENSMUST00000060187.15 olfactory receptor family 51 subfamily E member 2, transcript variant 1 (from RefSeq NM_130866.4) ENSMUST00000060187.1 ENSMUST00000060187.10 ENSMUST00000060187.11 ENSMUST00000060187.12 ENSMUST00000060187.13 ENSMUST00000060187.14 ENSMUST00000060187.2 ENSMUST00000060187.3 ENSMUST00000060187.4 ENSMUST00000060187.5 ENSMUST00000060187.6 ENSMUST00000060187.7 ENSMUST00000060187.8 ENSMUST00000060187.9 Mol2.3 NM_130866 O51E2_MOUSE Olfr78 Psgr Q8VBV9 uc009isl.1 uc009isl.2 uc009isl.3 uc009isl.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Olfactory receptor. The activity of this receptor is probably mediated by G-proteins wich induce elevation of intracellular Ca(2+), cAMP and activation of phosphorylation of the protein kinases PKA and MAPK3/MAPK1. Activation of OR51E2 may affect melanocyte proliferation, differentiation, and melanogenesis and may increase proliferation and migration of primary retinal pigment epithelial (RPE) cells (By similarity). Activated by the short chain fatty acids (SCFA), acetate and propionate (PubMed:23401498). In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (By similarity). Activated by L-lactate in glomus cells (PubMed:26560302, PubMed:30258151). Cell membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein In brain, expressed in medulla oblongata by cells close to the fourth ventricle, in the area postrema, the nucleus tractus solitarius (PubMed:11707321). Expressed in olfactory epithelium and vomeronasal organ (PubMed:11069588). Expressed in kidney by large renal vessels, renal afferent arterioles, and extrarenal vascular beds. In small resistance vessels the expression is restricted to cells of the juxtaglomerular afferent arteriole, which mediate renin secretion. Also detected in small blood vessels in a variety of tissues including heart, diaphragm, skeletal muscle, and skin. In the heart, esophagus, and stomach it is detected in axons of autonomic neurons and neurons of the enteric plexus (PubMed:23401498). Also detected in colon and liver (PubMed:23401498). Expressed in the glomus cells of the carotid body (PubMed:26560302). Primarily detected between 11 dpc and 12 dpc. Expressed at 12 dpc in the dorsal region of the developing nasal cavity and in the mesenchyme located between the olfactory epithelium and the presumptive olfactory bulb. In the medulla oblongata, first detected at 17 dpc. In the area postrema and the nucleus tractus solitarius expression peaks at P20 and then decreases slightly. Knockout mice display reduced baseline blood pressure. Belongs to the G-protein coupled receptor 1 family. Contradictory results have been reported for activation by beta-ionone in human and mouse. Beta-ionone does not activate OR51E2 in mouse. This difference may depend on the different methods used for these experiments, or may be due to species difference. Conflicting results for the role of OR51E2 in the regulation of breathing and its role as a hypoxia sensor activated by lactate are reported (PubMed:26560302, PubMed:30258151). It was first described as a hypoxia sensor in the breathing circuit by sensing lactate produced when oxygen levels decline (PubMed:26560302). A recent study fails to confirm a role for OR52E2 in this pathway (PubMed:30258151). Conflicting results may reflect the use of different strain backgrounds (PubMed:30258152, PubMed:26560302, PubMed:30258151). steroid hormone receptor activity G-protein coupled receptor activity olfactory receptor activity endosome plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane cell migration melanocyte differentiation early endosome membrane signaling receptor activity intracellular organelle steroid hormone mediated signaling pathway positive regulation of cAMP-mediated signaling positive regulation of blood pressure response to stimulus detection of chemical stimulus involved in sensory perception of smell cellular response to fatty acid melanocyte proliferation positive regulation of renin secretion into blood stream uc009isl.1 uc009isl.2 uc009isl.3 uc009isl.4 
ENSMUST00000060188.14 Ppp1r2 ENSMUST00000060188.14 protein phosphatase 1, regulatory inhibitor subunit 2 (from RefSeq NM_025800.3) ENSMUST00000060188.1 ENSMUST00000060188.10 ENSMUST00000060188.11 ENSMUST00000060188.12 ENSMUST00000060188.13 ENSMUST00000060188.2 ENSMUST00000060188.3 ENSMUST00000060188.4 ENSMUST00000060188.5 ENSMUST00000060188.6 ENSMUST00000060188.7 ENSMUST00000060188.8 ENSMUST00000060188.9 IPP2_MOUSE NM_025800 Q3UD25 Q8C1A6 Q9DCL8 uc007yxd.1 uc007yxd.2 uc007yxd.3 Inhibitor of protein-phosphatase 1. Heterodimer with PP1. Phosphorylation on Ser-45 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex. Phosphorylation on Thr-74 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex. Belongs to the protein phosphatase inhibitor 2 family. protein phosphatase inhibitor activity cytoplasm carbohydrate metabolic process glycogen metabolic process regulation of signal transduction protein domain specific binding growth cone negative regulation of protein binding negative regulation of phosphoprotein phosphatase activity dendritic spine regulation of phosphoprotein phosphatase activity uc007yxd.1 uc007yxd.2 uc007yxd.3 
ENSMUST00000060210.14 Gpm6b ENSMUST00000060210.14 glycoprotein m6b, transcript variant 5 (from RefSeq NM_023122.4) A2AEG4 ENSMUST00000060210.1 ENSMUST00000060210.10 ENSMUST00000060210.11 ENSMUST00000060210.12 ENSMUST00000060210.13 ENSMUST00000060210.2 ENSMUST00000060210.3 ENSMUST00000060210.4 ENSMUST00000060210.5 ENSMUST00000060210.6 ENSMUST00000060210.7 ENSMUST00000060210.8 ENSMUST00000060210.9 GPM6B_MOUSE M6b NM_023122 P35803 Q8R3J6 Q99L14 Q9D4F5 Q9JHG9 Q9JHI1 Q9JHK2 Q9JI62 Q9JI63 Q9JI64 Q9JI65 uc009uwg.1 uc009uwg.2 uc009uwg.3 uc009uwg.4 May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. Interacts with SERT. Membrane; Multi-pass membrane protein. Cell membrane. Note=Colocalizes with SERT at the plasma membrane. Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=Alpha-beta-TMD-omega; IsoId=P35803-1; Sequence=Displayed; Name=2; Synonyms=Alpha-beta-TMD-psi; IsoId=P35803-2; Sequence=VSP_007324, VSP_007325; Name=3; Synonyms=TMD-omega; IsoId=P35803-3; Sequence=VSP_007318; Name=4; Synonyms=Alpha-TMD-psi; IsoId=P35803-4; Sequence=VSP_007320, VSP_007324, VSP_007325; Name=5; Synonyms=TMD-psi; IsoId=P35803-5; Sequence=VSP_007318, VSP_007324, VSP_007325; Name=6; Synonyms=Alpha-beta-gamma; IsoId=P35803-6; Sequence=VSP_007322, VSP_007323; Name=7; Synonyms=Alpha-gamma; IsoId=P35803-7; Sequence=VSP_007319, VSP_007321; Name=8; Synonyms=Alpha-TMD-omega; IsoId=P35803-8; Sequence=VSP_007320; Widely expressed. In the brain, expressed in neurons and oligodendrocytes. First detected in presumptive postmitotic neurons in the developing neural tube at embryonic day 9. Belongs to the myelin proteolipid protein family. ossification plasma membrane protein transport membrane integral component of membrane positive regulation of bone mineralization neuron projection development regulation of actin cytoskeleton organization membrane raft negative regulation of serotonin uptake regulation of focal adhesion assembly extracellular matrix assembly negative regulation of protein localization to cell surface uc009uwg.1 uc009uwg.2 uc009uwg.3 uc009uwg.4 
ENSMUST00000060214.10 Tmem125 ENSMUST00000060214.10 transmembrane protein 125 (from RefSeq NM_172383.3) A2BI56 ENSMUST00000060214.1 ENSMUST00000060214.2 ENSMUST00000060214.3 ENSMUST00000060214.4 ENSMUST00000060214.5 ENSMUST00000060214.6 ENSMUST00000060214.7 ENSMUST00000060214.8 ENSMUST00000060214.9 NM_172383 Q8BHY6 Q8CHQ6 TM125_MOUSE uc012dkb.1 uc012dkb.2 uc012dkb.3 Membrane ; Multi-pass membrane protein Sequence=AAH39806.2; Type=Erroneous initiation; Evidence=; Sequence=BAC34092.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc012dkb.1 uc012dkb.2 uc012dkb.3 
ENSMUST00000060223.4 Ptgr3 ENSMUST00000060223.4 prostaglandin reductase 3, transcript variant 1 (from RefSeq NM_146090.6) ENSMUST00000060223.1 ENSMUST00000060223.2 ENSMUST00000060223.3 NM_146090 PTGR3_MOUSE Ptgr3 Q8BGC4 Zadh2 uc008fun.1 uc008fun.2 uc008fun.3 Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Reaction=13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15- oxoprostaglandin E2 + H(+) + NADPH; Xref=Rhea:RHEA:11912, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57402, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.48; Evidence=; Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15- oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584, ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133408; Evidence=; Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374, ChEBI:CHEBI:133409; Evidence=; Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15- oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:79072, ChEBI:CHEBI:133411; Evidence=; Kinetic parameters: KM=55.0 uM for 15-keto-PGE2 ; KM=75.1 uM for 15-keto-PGE1 ; KM=42.5 uM for 15-keto-PGF2-alpha ; KM=53.5 uM for 15-keto-PGF1-alpha ; Vmax=215.4 nmol/min/mg enzyme with 15-keto-PGE2 as substrate ; Vmax=109.6 nmol/min/mg enzyme with 15-keto-PGE1 as substrate ; Vmax=303.3 nmol/min/mg enzyme with 15-keto-PGF2-alpha as substrate ; Vmax=286.2 nmol/min/mg enzyme with 15-keto-PGF1-alpha as substrate ; Note=kcat is 8.6 min(-1) for 15-keto-PGE2, 4.37 min(-1) for 15-keto- PGE1, 11.55 for min(-1) for 15-keto-PGF2-alpha, 11.45 min(-1) for 15- keto-PGF1-alpha. ; Peroxisome Widely expressed. Up-regulated by high fat diet (PubMed:19091015). Down- regulated in white adipose tissue in ob/on mice (PubMed:23821743). Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. mitochondrion peroxisome prostaglandin metabolic process zinc ion binding oxidoreductase activity 13-prostaglandin reductase activity negative regulation of fat cell differentiation 15-oxoprostaglandin 13-oxidase activity oxidation-reduction process uc008fun.1 uc008fun.2 uc008fun.3 
ENSMUST00000060225.6 Gpr4 ENSMUST00000060225.6 G protein-coupled receptor 4 (from RefSeq NM_175668.4) ENSMUST00000060225.1 ENSMUST00000060225.2 ENSMUST00000060225.3 ENSMUST00000060225.4 ENSMUST00000060225.5 GPR4_MOUSE NM_175668 Q8BUD0 uc009flb.1 uc009flb.2 uc009flb.3 uc009flb.4 Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways (PubMed:17145776). Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway (PubMed:32058960). In the brain may mediate central respiratory sensitivity to CO(2)/H(+) (PubMed:26068853). Cell membrane ; Multi-pass membrane protein Detected in neurons of the brain-stem retrotrapezoid nucleus (RTN). Deficient mice display partial neonatal and postnatal lethality, hemorrhages, impaired association of vascular smooth muscle cells with capillaries and small arteries and veins, and impaired contact between mesangial cells and renal glomerular capillaries (PubMed:17145776). The inflammatory response is reduced in an inflammatory hindlimb ischemia-reperfusion model (PubMed:26068853). Deficient mice display reduced central respiratory chemoreflex, increased apnea frequency, and blunted ventilatory responses to CO2 (PubMed:32058960). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway response to acidic pH membrane integral component of membrane negative regulation of angiogenesis positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway angiogenesis involved in wound healing glomerular mesangial cell development uc009flb.1 uc009flb.2 uc009flb.3 uc009flb.4 
ENSMUST00000060226.11 Tmed2 ENSMUST00000060226.11 transmembrane p24 trafficking protein 2, transcript variant 2 (from RefSeq NM_019770.3) ENSMUST00000060226.1 ENSMUST00000060226.10 ENSMUST00000060226.2 ENSMUST00000060226.3 ENSMUST00000060226.4 ENSMUST00000060226.5 ENSMUST00000060226.6 ENSMUST00000060226.7 ENSMUST00000060226.8 ENSMUST00000060226.9 NM_019770 Q9R0Q3 Rnp24 Sid394 TMED2_MOUSE uc008zqa.1 uc008zqa.2 uc008zqa.3 Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle- mediated anterograde transport involved in the transport of GPI- anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing (By similarity). Required for morphogenesis of embryo and placenta. Monomer and homodimer in the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and Golgi. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED7, TMED9 and TMED10. Interacts (via GOLD domain) with TMED10 (via GOLD domain). Associates with the COPI vesicle coat (coatomer); TMED10:TMED2 heterotetramers are proposed to be involved in coatomer association. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED2. Interacts with SEC23A; indicative for an association of TMED2 with the COPII vesicle coat. Interacts with ARF1 and ARFGAP1. Interacts with CD59, SEC24A, SEC24B, SEC24C, SEC24D and ATL1. Interacts with KDELR1; the interaction is decreased by KDEL ligand. Interacts with F2RL1; the interaction occurs at the Golgi apparatus. Interacts with CASR (immaturely glycosylated form); the interaction occurs in the endoplasmic reticulum-Golgi intermediate compartment or cis-Golgi. Interacts with F2RL1; the interaction occurs at the Golgi apparatus. Interacts with GORASP1 and GORASP2. Found in a complex composed at least of SURF4, TMED2 and TMED10 (By similarity). Cytoplasmic vesicle membrane ; Single-pass type I membrane protein Cytoplasmic vesicle, COPI-coated vesicle membrane ; Single-pass type I membrane protein Golgi apparatus, cis-Golgi network membrane ; Single-pass type I membrane protein Golgi apparatus, Golgi stack membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein Note=Cycles between compartments of the early secretatory pathway. Expressed during embryonal and placental development. Embryonic lethal for homozygotes with Glu-15 in the signal peptide. Animals do not show Tmed2 protein expression and also have reduced protein levels of Tmed7 and Tmed10. Prior to death at mid- gestation, embryos exhibit developmental delay, abnormal rostral-caudal elongation, randomized heart looping, and absence of the labyrinth layer of the placenta. Belongs to the EMP24/GP25L family. in utero embryonic development somitogenesis neural tube closure embryonic placenta development maternal placenta development heart looping molecular_function endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus intracellular protein transport ER to Golgi vesicle-mediated transport Golgi organization positive regulation of gene expression protein transport membrane integral component of membrane vesicle-mediated transport ER to Golgi transport vesicle COPI-coated vesicle cytoplasmic vesicle membrane COPI-coated vesicle membrane cytoplasmic vesicle somite rostral/caudal axis specification Golgi cisterna membrane endoplasmic reticulum-Golgi intermediate compartment membrane negative regulation of GTPase activity multicellular organism growth post-anal tail morphogenesis zymogen granule membrane intracellular membrane-bounded organelle embryonic morphogenesis labyrinthine layer blood vessel development protein localization to plasma membrane uc008zqa.1 uc008zqa.2 uc008zqa.3 
ENSMUST00000060232.8 Rab2a ENSMUST00000060232.8 RAB2A, member RAS oncogene family, transcript variant 1 (from RefSeq NM_021518.4) ENSMUST00000060232.1 ENSMUST00000060232.2 ENSMUST00000060232.3 ENSMUST00000060232.4 ENSMUST00000060232.5 ENSMUST00000060232.6 ENSMUST00000060232.7 NM_021518 Q0PD65 Q0PD65_MOUSE Rab2 Rab2A Rab2a uc008rxw.1 uc008rxw.2 uc008rxw.3 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Cytoplasmic vesicle, secretory vesicle, acrosome Endoplasmic reticulum membrane ; Lipid-anchor Endoplasmic reticulum-Golgi intermediate compartment membrane ; Lipid-anchor Golgi apparatus membrane ; Lipid-anchor Melanosome Membrane ; Lipid-anchor Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding Golgi organization GDP binding uc008rxw.1 uc008rxw.2 uc008rxw.3 
ENSMUST00000060241.3 Otud6a ENSMUST00000060241.3 OTU domain containing 6A (from RefSeq NM_001163191.3) A2ADU1 A8E630 ENSMUST00000060241.1 ENSMUST00000060241.2 Hin6 NM_001163191 OTU6A_MOUSE Q6IE21 uc012hms.1 uc012hms.2 Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys- 29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; thiol-dependent ubiquitin-specific protease activity cellular_component proteolysis peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity protein K29-linked deubiquitination protein K11-linked deubiquitination thiol-dependent ubiquitinyl hydrolase activity protein K27-linked deubiquitination protein K33-linked deubiquitination uc012hms.1 uc012hms.2 
ENSMUST00000060251.8 Higd1a ENSMUST00000060251.8 HIG1 domain family, member 1A, transcript variant 5 (from RefSeq NM_019814.5) ENSMUST00000060251.1 ENSMUST00000060251.2 ENSMUST00000060251.3 ENSMUST00000060251.4 ENSMUST00000060251.5 ENSMUST00000060251.6 ENSMUST00000060251.7 HIG1A_MOUSE Hig1 NM_019814 Q9JLR9 uc009seb.1 uc009seb.2 uc009seb.3 uc009seb.4 Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). Associates with cytochrome c oxidase (COX, complex IV); proposed complex component. Also associates with respiratory chain supercomplexes (By similarity). Mitochondrion membrane ulti-pass membrane protein tochondrion inner membrane By hypoxia. molecular_function nucleus nucleoplasm mitochondrion mitochondrial inner membrane membrane integral component of membrane mitochondrial membrane macromolecular complex cellular response to glucose starvation negative regulation of apoptotic process oxidation-reduction process respiratory chain cellular response to hypoxia positive regulation of protein serine/threonine kinase activity negative regulation of release of cytochrome c from mitochondria uc009seb.1 uc009seb.2 uc009seb.3 uc009seb.4 
ENSMUST00000060253.5 Fem1a ENSMUST00000060253.5 fem 1 homolog a (from RefSeq NM_010192.4) ENSMUST00000060253.1 ENSMUST00000060253.2 ENSMUST00000060253.3 ENSMUST00000060253.4 Eprap FM1AA_MOUSE Fem1a Fem1aa NM_010192 Q3U2C2 Q8C4V3 Q8C6D9 Q8CBW9 Q9DBC6 Q9Z2G1 uc008dbk.1 uc008dbk.2 uc008dbk.3 uc008dbk.4 Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C- degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (By similarity). Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (PubMed:18270204, PubMed:26439841). Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (PubMed:27315781). Protein modification; protein ubiquitination. Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter FEM1A (By similarity). Interacts with PTGER4 (PubMed:18270204). Interacts with NFKB1; the interaction is direct (PubMed:18270204). Mitochondrion Cytoplasm Preferentially expressed in cardiac muscle, brain and liver (at protein level) (PubMed:9828124, PubMed:19406122). Also expressed in skeletal muscle (PubMed:9828124). Expressed during embryogenesis. Up-regulated in ischemic hearts. Phosphorylated; highly phosphorylated in myoblasts and myotubes (PubMed:19406122). Phosphorylation at Ser-108 and Ser-608 promote PGE2- EP4-mediated inhibition of inflammation (PubMed:27799315). Dephosphorylated by protein phosphatase 2A (PP2A) (PubMed:27799315). No visible phenotype in normal conditions: mice are fertile and develop normally without any apparent malformation (PubMed:26439841, PubMed:27315781). In mice model of chronic inflammation, mice develop more severe colitis induced by dextran sodium sulfate (DSS) (PubMed:26439841). Mice display less microglial accumulation; decreased microglial activation is observed in the brain after systemic lipopolysaccharide administration (PubMed:27315781). Mice also show behavioral abnormalities, possibly caused by monoamine deficits (PubMed:28336432). Mice display reduced anxiety-like behavior and brain inflammation in a model of Alzheimer disease (PubMed:28624505). Belongs to the fem-1 family. Sequence=BAC28699.1; Type=Frameshift; Evidence=; ubiquitin-protein transferase activity cellular_component cytoplasm transcription factor binding protein ubiquitination EP4 subtype prostaglandin E2 receptor binding negative regulation of MAP kinase activity negative regulation of inflammatory response regulation of ubiquitin-protein transferase activity uc008dbk.1 uc008dbk.2 uc008dbk.3 uc008dbk.4 
ENSMUST00000060265.6 Naa11 ENSMUST00000060265.6 N(alpha)-acetyltransferase 11, NatA catalytic subunit (from RefSeq NM_001033191.2) Ard1b Ard2 ENSMUST00000060265.1 ENSMUST00000060265.2 ENSMUST00000060265.3 ENSMUST00000060265.4 ENSMUST00000060265.5 NAA11_MOUSE NM_001033191 Q3UX61 Q3V0C7 uc008yfw.1 uc008yfw.2 uc008yfw.3 Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex. Reaction=acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetylglycyl-[protein]; Xref=Rhea:RHEA:50496, Rhea:RHEA-COMP:12666, Rhea:RHEA-COMP:12700, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64723, ChEBI:CHEBI:133369; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-alanyl-[protein]; Xref=Rhea:RHEA:50500, Rhea:RHEA-COMP:12701, Rhea:RHEA-COMP:12702, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64718, ChEBI:CHEBI:83683; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-seryl-[protein]; Xref=Rhea:RHEA:50504, Rhea:RHEA-COMP:12703, Rhea:RHEA-COMP:12704, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64738, ChEBI:CHEBI:83690; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-valyl-[protein]; Xref=Rhea:RHEA:50508, Rhea:RHEA-COMP:12705, Rhea:RHEA-COMP:12706, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64741, ChEBI:CHEBI:133371; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:50512, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:12708, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:65250, ChEBI:CHEBI:133372; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-threonyl-[protein]; Xref=Rhea:RHEA:50516, Rhea:RHEA-COMP:12709, Rhea:RHEA-COMP:12710, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64739, ChEBI:CHEBI:133375; EC=2.3.1.255; Evidence=; Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA11 and NAA15. Interacts with HIF1A. Cytoplasm Nucleus Belongs to the acetyltransferase family. ARD1 subfamily. peptide alpha-N-acetyltransferase activity nucleus cytoplasm N-terminal protein amino acid acetylation N-acetyltransferase activity transferase activity transferase activity, transferring acyl groups N-terminal peptidyl-serine acetylation N-terminal peptidyl-glutamic acid acetylation NatA complex peptide-serine-N-acetyltransferase activity peptide-glutamate-N-acetyltransferase activity uc008yfw.1 uc008yfw.2 uc008yfw.3 
ENSMUST00000060270.13 Zfp473 ENSMUST00000060270.13 zinc finger protein 473, transcript variant 3 (from RefSeq NM_178734.4) ENSMUST00000060270.1 ENSMUST00000060270.10 ENSMUST00000060270.11 ENSMUST00000060270.12 ENSMUST00000060270.2 ENSMUST00000060270.3 ENSMUST00000060270.4 ENSMUST00000060270.5 ENSMUST00000060270.6 ENSMUST00000060270.7 ENSMUST00000060270.8 ENSMUST00000060270.9 NM_178734 Q8BI67 Q8BI98 Q8BIB7 ZN473_MOUSE Zfp100 Znf473 uc009gqp.1 uc009gqp.2 uc009gqp.3 uc009gqp.4 Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases (By similarity). Interacts with the SLBP/pre-mRNA complex but not with SLBP alone. Interacts with LSM11 in a U7 snRNP-dependent manner (By similarity). Nucleus Note=Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA (By similarity). The C2H2-type zinc fingers are involved in discrete Cajal bodies localization, interaction with LSM11 and the SLBP/RNA complex and histone pre-mRNA processing. Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated mRNA 3'-end processing by stem-loop binding and cleavage Cajal body metal ion binding uc009gqp.1 uc009gqp.2 uc009gqp.3 uc009gqp.4 
ENSMUST00000060271.3 Foxi1 ENSMUST00000060271.3 forkhead box I1 (from RefSeq NM_023907.4) ENSMUST00000060271.1 ENSMUST00000060271.2 FOXI1_MOUSE NM_023907 Q5SRI5 Q922I5 Q9D299 uc007ikw.1 uc007ikw.2 uc007ikw.3 Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules. Nucleus. Expressed in intercalated cells of the epithelium of the distal renal tubule. Expressed in the entire otic vesicle at stage 9.5 dpc gradually restricted to the epithelium of the endolymphatic ducts at stage 16.5 dpc. Mice are deaf, impaired in their sense of balance and suffer from distal renal tubular acidosis. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleolus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter anatomical structure morphogenesis cell differentiation inner ear morphogenesis intracellular membrane-bounded organelle sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc007ikw.1 uc007ikw.2 uc007ikw.3 
ENSMUST00000060301.6 Ly6k ENSMUST00000060301.6 lymphocyte antigen 6 family member K (from RefSeq NM_029627.2) ENSMUST00000060301.1 ENSMUST00000060301.2 ENSMUST00000060301.3 ENSMUST00000060301.4 ENSMUST00000060301.5 LY6K_MOUSE Ly6k NM_029627 Q9CWP4 uc007wga.1 uc007wga.2 uc007wga.3 Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (PubMed:24501175). May play a role in cell growth (By similarity). Interacts with ADAM3 and TEX101. Secreted Cytoplasm Cell membrane ; Lipid-anchor, GPI-anchor Cytoplasmic vesicle, secretory vesicle, acrosome Membrane raft Strongly expressed in testes and weakly expressed in the epididymis, ovary, and uterus (PubMed:20920470). Expressed in testicular germ cells (TGCs) (PubMed:24501175). Expressed in the testicular seminiferous tubules, in spermatocytes, spermatids, and testicular spermatozoa (PubMed:27005865). Weakly expressed in testes from 18 day postcoitus to 1 day postpartum (dpp), with a plateau starting around 8 dpp; and testicular expression shows two-peak expression at around 14 dpp and 24 dpp, then exhibits stable expression from 6-week after birth onward. Knockout Ly6k mice are viable and show no overt developmental abnormalities. Males are infertile. acrosomal vesicle protein binding extracellular region cytoplasm plasma membrane binding of sperm to zona pellucida cell surface membrane flagellated sperm motility anchored component of membrane cytoplasmic vesicle membrane raft uc007wga.1 uc007wga.2 uc007wga.3 
ENSMUST00000060303.10 Tshz1 ENSMUST00000060303.10 teashirt zinc finger family member 1, transcript variant 1 (from RefSeq NM_001081300.2) ENSMUST00000060303.1 ENSMUST00000060303.2 ENSMUST00000060303.3 ENSMUST00000060303.4 ENSMUST00000060303.5 ENSMUST00000060303.6 ENSMUST00000060303.7 ENSMUST00000060303.8 ENSMUST00000060303.9 Kiaa4206 NM_001081300 Q5DTH5 Q6PE60 Q8VD19 Q9JLD5 Sdccag33 TSH1_MOUSE Tsh1 uc008fum.1 uc008fum.2 uc008fum.3 Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Interacts (via homeobox domain) with APBB1 (via PID domain 1). Nucleus From 12.5 dpc, expressed in the mesenchyme of the developing middle ear, within areas surrounding the condensing malleus and tympanic ring and on both sides of the external acoustic meatus. At 12.5 dpc, borders and surrounds the future cartilages, but excluded from cartilaginous condensations. Not detected in mesenchymal cells in proximal ureters at 14 dpc. Normal Mendelian ratio at birth, but none of the mutant animals survive beyond P0. Newborn mutant mice exhibit a strong defect of the soft palate, vertebral malformations in the cervical and thoracic regions of the axial skeleton and malformations in the middle ear components. Belongs to the teashirt C2H2-type zinc-finger protein family. Sequence=AAF63158.1; Type=Frameshift; Evidence=; Sequence=AAH58264.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD90534.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleic acid binding DNA binding chromatin binding protein binding nucleus regulation of transcription from RNA polymerase II promoter multicellular organism development anterior/posterior pattern specification regulation of gene expression middle ear morphogenesis metal ion binding soft palate development uc008fum.1 uc008fum.2 uc008fum.3 
ENSMUST00000060311.12 Hip1 ENSMUST00000060311.12 huntingtin interacting protein 1, transcript variant 3 (from RefSeq NR_168637.1) ENSMUST00000060311.1 ENSMUST00000060311.10 ENSMUST00000060311.11 ENSMUST00000060311.2 ENSMUST00000060311.3 ENSMUST00000060311.4 ENSMUST00000060311.5 ENSMUST00000060311.6 ENSMUST00000060311.7 ENSMUST00000060311.8 ENSMUST00000060311.9 HIP1_MOUSE Hip1 Kiaa4113 NR_168637 Q3TLS2 Q571K7 Q8VD75 uc008zyk.1 uc008zyk.2 uc008zyk.3 uc008zyk.4 uc008zyk.5 uc008zyk.6 Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11577110). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (PubMed:12839988, PubMed:17329427). Regulates presynaptic nerve terminal activity (PubMed:17928447). Enhances androgen receptor (AR)- mediated transcription (By similarity). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (By similarity). Binds 3-phosphoinositides (via ENTH domain) (By similarity). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (By similarity). May play a functional role in the cell filament networks (By similarity). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11604514, PubMed:14998932, PubMed:16967501, PubMed:17928447). Homodimer. Binds actin. Binds HTT (via N-terminus). This interaction is restricted to the brain. Binds to IFT57. In normal conditions, it poorly interacts with IFT57, HIP1 being strongly associated with HTT. However, in mutant HTT proteins with a long poly- Gln region, interaction between HTT and HIP1 is inhibited, promoting the interaction between HIP1 and IFT57. Interacts with CLTB (via N- terminus). Interacts (via coiled coil domain) with AR. Interacts with AP2A1, AP2A2, CLTC and HIP1R (By similarity). Interacts with GRIA1, GRIN2A and GRIN2B. Cytoplasm Nucleus Endomembrane system Cytoplasmic vesicle, clathrin-coated vesicle membrane Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR (By similarity). Most abundantly expressed in brain. In brain, expressed in cortical tissue, hippocampus, the molecular layer of the cerebellum and olfactory bulb. Also expressed in spinal cord and bone marrow (at protein level). Expressed in reproductive tissues. The pseudo DED region (pDED) mediates the interaction with IFT57. Binds F-actin via the talin-like I/LWEQ domain. Mice develop a neurological phenotype by 3 months of age, characterized by wasting, tremor and a gait ataxia secondary to a rigid thoracolumbar kyphosis (PubMed:12839988, PubMed:14998932). Recovery of synaptic transmission following synaptic depression induced by prolonged nerve stimulation is reduced (PubMed:17928447). Paired- pulse facilitation, a form of neuronal plasticity in which delivery of two stimuli within a second of each other produces an increase in the size of the second synaptic response, is enhanced (PubMed:17928447). They also display micro-ophthalmia with nuclear cataracts (PubMed:14998932). Mutant male mice are mostly infertile and exhibit testicular degeneration with increased apoptosis of postmeiotic spermatids (PubMed:11604514, PubMed:16967501). Hip1 and Hip1r double- knockout mice are dwarfed, afflicted with severe vertebral defects and die in early adulthood (PubMed:17452370). Belongs to the SLA2 family. Sequence=AAH17516.1; Type=Erroneous initiation; Evidence=; actin binding protein binding phospholipid binding nucleus cytoplasm Golgi apparatus endocytosis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process actin filament organization endomembrane system membrane clathrin-coated vesicle cell differentiation clathrin binding actin cortical patch clathrin-coated vesicle membrane extrinsic component of cytoplasmic side of plasma membrane cytoplasmic vesicle clathrin light chain binding phosphatidylinositol-3-phosphate binding phosphatidylinositol binding AP-2 adaptor complex binding clathrin adaptor activity protein homodimerization activity regulation of apoptotic process intracellular membrane-bounded organelle phosphatidylinositol-3,4-bisphosphate binding postsynaptic membrane positive regulation of epidermal growth factor receptor signaling pathway protein heterodimerization activity positive regulation of receptor-mediated endocytosis clathrin coat assembly protein stabilization actin filament binding clathrin-dependent endocytosis phosphatidylinositol-3,5-bisphosphate binding apoptotic signaling pathway presynapse postsynapse extrinsic component of presynaptic membrane extrinsic component of postsynaptic membrane glutamatergic synapse positive regulation of platelet-derived growth factor receptor-beta signaling pathway uc008zyk.1 uc008zyk.2 uc008zyk.3 uc008zyk.4 uc008zyk.5 uc008zyk.6 
ENSMUST00000060327.4 Skint10 ENSMUST00000060327.4 selection and upkeep of intraepithelial T cells 10 (from RefSeq NM_177668.2) A7TZG1 A7TZG2 ENSMUST00000060327.1 ENSMUST00000060327.2 ENSMUST00000060327.3 NM_177668 Q8CAZ8 SKI10_MOUSE uc008udy.1 uc008udy.2 uc008udy.3 May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. Membrane ; Multi-pass membrane protein Expressed in skin and thymus. Encoded by one of the 11 copies of Skint genes clustered in the D1 region of the chromosome 4. Belongs to the SKINT family. Sequence=ABS30727.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=ABS30728.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; receptor binding external side of plasma membrane membrane integral component of membrane regulation of immune response T cell receptor signaling pathway uc008udy.1 uc008udy.2 uc008udy.3 
ENSMUST00000060328.9 Spink14 ENSMUST00000060328.9 serine peptidase inhibitor, Kazal type 14 (from RefSeq NM_001039218.2) B9EJP9 B9EJP9_MOUSE EG433178 ENSMUST00000060328.1 ENSMUST00000060328.2 ENSMUST00000060328.3 ENSMUST00000060328.4 ENSMUST00000060328.5 ENSMUST00000060328.6 ENSMUST00000060328.7 ENSMUST00000060328.8 Gm5505 NM_001039218 Spink14 uc008euq.1 uc008euq.2 uc008euq.1 uc008euq.2 
ENSMUST00000060330.5 1700012B09Rik ENSMUST00000060330.5 RIKEN cDNA 1700012B09 gene (from RefSeq NM_029306.3) CK097_MOUSE ENSMUST00000060330.1 ENSMUST00000060330.2 ENSMUST00000060330.3 ENSMUST00000060330.4 NM_029306 Q9DAE7 uc009oey.1 uc009oey.2 uc009oey.3 uc009oey.4 Cytoplasm, cytoskeleton, cilium basal body Predominantly expressed in tissues containing motile cilia (PubMed:28666954, PubMed:27914912). Also expressed in non- motile ciliated adult olfactory bulbs (PubMed:28666954). Expressed in the developing fetal lung epithelium, embryonic ventral node and developing brain (at protein level) (PubMed:28666954, PubMed:27914912). Expression is activated by FOXJ1 and NOTO. Mice exhibited no impaired function of motile cilia or non-motile cilia. molecular_function cytoplasm cytoskeleton ciliary basal body cell projection ciliary base cilium assembly uc009oey.1 uc009oey.2 uc009oey.3 uc009oey.4 
ENSMUST00000060336.5 Fgf4 ENSMUST00000060336.5 fibroblast growth factor 4 (from RefSeq NM_010202.6) ENSMUST00000060336.1 ENSMUST00000060336.2 ENSMUST00000060336.3 ENSMUST00000060336.4 FGF4_MOUSE Fgf-4 Fgf4 Kfgf NM_010202 P11403 P15657 Q542N0 uc009kqq.1 uc009kqq.2 Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Is essential for survival of the postimplantation mouse embryo. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells (PubMed:8898217). Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity). Secreted Expressed in the blastocyst inner cell mass and later in distinct embryonic tissues. Belongs to the heparin-binding growth factors family. cartilage condensation positive regulation of protein phosphorylation fibroblast growth factor receptor binding protein binding extracellular region multicellular organism development growth factor activity positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway mesenchymal cell proliferation regulation of gene expression positive regulation of gene expression stem cell population maintenance cell differentiation embryonic limb morphogenesis embryonic hindlimb morphogenesis odontogenesis of dentin-containing tooth negative regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter positive regulation of cell division cranial suture morphogenesis apoptotic process involved in morphogenesis chondroblast differentiation positive regulation of ERK1 and ERK2 cascade cellular response to leukemia inhibitory factor regulation of endothelial cell chemotaxis to fibroblast growth factor uc009kqq.1 uc009kqq.2 
ENSMUST00000060348.3 5330417H12Rik ENSMUST00000060348.3 5330417H12Rik (from geneSymbol) AK017242 ENSMUST00000060348.1 ENSMUST00000060348.2 uc291ufb.1 uc291ufb.2 uc291ufb.1 uc291ufb.2 
ENSMUST00000060356.8 Foxi2 ENSMUST00000060356.8 forkhead box I2 (from RefSeq NM_183193.3) ENSMUST00000060356.1 ENSMUST00000060356.2 ENSMUST00000060356.3 ENSMUST00000060356.4 ENSMUST00000060356.5 ENSMUST00000060356.6 ENSMUST00000060356.7 FOXI2_MOUSE Foxi2 NM_183193 Q3I5G5 Q8BIK9 uc009kec.1 uc009kec.2 uc009kec.3 uc009kec.4 Possible transcriptional activator. Nucleus. Expressed in a subset of cells of the olfactory epithelium, in the dental epithelium, in developing whiskers and in cells lining the endolymphatic duct of the inner ear at stage 16.5 dpc. Also expressed in kidney, hair follicles, thymus and in collecting ducts from the mandibular gland as well as in a subset of epithelial cells lining the sublingual and submaxillary ducts from the salivary glands to the oral cavity at stage 18.5 dpc. Expressed in the developing brain along a neuromeric boundary between prosomeres p5 and p6 as well as in the neural layer of the retina. Sequence=AAH96623.1; Type=Erroneous initiation; Evidence=; Sequence=BAC32291.1; Type=Erroneous initiation; Evidence=; RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter anatomical structure morphogenesis cell differentiation sequence-specific DNA binding uc009kec.1 uc009kec.2 uc009kec.3 uc009kec.4 
ENSMUST00000060357.15 1700067K01Rik ENSMUST00000060357.15 1700067K01Rik (from geneSymbol) 1700067K01Rik A0A6E0D3Q4 A0A6E0D3Q4_MOUSE AK006917 ENSMUST00000060357.1 ENSMUST00000060357.10 ENSMUST00000060357.11 ENSMUST00000060357.12 ENSMUST00000060357.13 ENSMUST00000060357.14 ENSMUST00000060357.2 ENSMUST00000060357.3 ENSMUST00000060357.4 ENSMUST00000060357.5 ENSMUST00000060357.6 ENSMUST00000060357.7 ENSMUST00000060357.8 ENSMUST00000060357.9 mCG_5924 uc012ggv.1 uc012ggv.2 uc012ggv.3 uc012ggv.1 uc012ggv.2 uc012ggv.3 
ENSMUST00000060366.7 Zfp36l2 ENSMUST00000060366.7 zinc finger protein 36, C3H type-like 2 (from RefSeq NM_001001806.2) B9EIF6 ENSMUST00000060366.1 ENSMUST00000060366.2 ENSMUST00000060366.3 ENSMUST00000060366.4 ENSMUST00000060366.5 ENSMUST00000060366.6 NM_001001806 P23949 Q3TCE3 Q3TU59 TISD_MOUSE Tis11d Zfp36l2 uc008dsq.1 uc008dsq.2 uc008dsq.3 uc008dsq.4 uc008dsq.5 Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:22701344, PubMed:22367205, PubMed:25505318, PubMed:24830504, PubMed:27102483). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:22701344, PubMed:22367205, PubMed:25505318, PubMed:24830504). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12- myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (By similarity). Positively regulates early adipogenesis by promoting ARE- mediated mRNA decay of immediate early genes (IEGs) (PubMed:22701344). Plays a role in mature peripheral neuron integrity by promoting ARE- containing mRNA decay of the transcriptional repressor REST mRNA (PubMed:25505318). Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA (PubMed:24830504). Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid- induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation (PubMed:19633199, PubMed:23748442). In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation (PubMed:27102483). Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (PubMed:20622884). Associates with the cytoplasmic CCR4-NOT deadenylase to trigger ARE-containing mRNA deadenylation and decay processes. Interacts with CNOT7; this interaction is inhibited in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner. Interacts with CNOT6L. Nucleus toplasm te=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (PubMed:11796723, PubMed:22367205). Expressed in preadipocytes and adipocytes (at protein level) (PubMed:22701344). Expressed at highest level in lymphoid tissues such as thymus, spleen, lung, uterus, ovary, small and large intestine, mammary gland, fat and bone marrow (PubMed:19633199, PubMed:22367205). Expressed at intermediate level in kidney, heart, adrenal, eye and fetal liver (PubMed:19633199). Weakly expressed in brain, skeletal muscle and liver (PubMed:19633199, PubMed:22367205). Expressed through B lymphocyte development (PubMed:27102483). Expressed in superior cervical ganglion (SCG) and dorsal root ganglion (DRG) (PubMed:25505318). Expressed in embryonic stem cells (ESCs) (PubMed:24733888). Expressed in oocytes. In embryos, expression is detected at 7 dpc, increases at 9.5 dpc, and then remains constant through 18.5 dpc (PubMed:19633199). Expression in the yolk sac is relatively constant between 10.5 dpc and 18.5 dpc (PubMed:19633199). Placenta expression is also constant throughout development with a slight decrease observed at 18.5 dpc (PubMed:19633199). Expressed in burst-forming unit-erythroid (BFU-E) progenitor cells and down-regulated as erythroid cells differentiate (PubMed:23748442). Up-regulated in response to fibroblast growth factor FGF4 in embryonic stem cells (ESCs) in a p38 MAPK-dependent manner (at protein level) (PubMed:24733888). Up-regulated by glucocorticoid agonists, such as dexamethasone (DEX), in burst-forming unit-erythroid (BFU-E) progenitors in a receptor NR3C1-dependent manner (PubMed:23748442). Down-regulated during erythroid cell differentiation (PubMed:23748442). Down-regulated during the conversion from quiescence to activated satellite cells upon muscle injury (PubMed:23046558, PubMed:25815583). Phosphorylated by RPS6KA1 at Ser-480 and Ser-482 upon phorbol 12- myristate 13-acetate (PMA) treatment; this phosphorylation results in dissociation of the CCR4-NOT-deadenylase complex and induces p38 MAPK- mediated stabilization of the low-density lipoprotein (LDL) receptor (LDLR) mRNA (By similarity). Phosphorylation occurs during early preadipocyte differentiation (PubMed:22701344). Lethality between 2 weeks of birth, due to pancytopenia (PubMed:19633199). Peripheral blood shows a decrease in red and white cells, hemoglobin, hematocrit and platelets (PubMed:19633199). Yolk sacs from 11.5 dpc and fetal livers from 14.5 dpc display markedly reduced numbers of definitive multilineage and lineage-committed hematopoietic progenitors (PubMed:19633199). Mice lacking the N-terminus (DeltaN-ZFP36L2) display female infertility, with embryos that cannot progress beyond the 2-cell stage of development (PubMed:15342461). Show evidence of axonal and fiber degeneration (PubMed:25505318). Exhibit increased REST mRNA stability and REST protein expression in primary neuronal cells from superior cervical ganglion (SCG) and dorsal root ganglion (DRG) (PubMed:25505318). Mice lacking both ZFP36L2 and ZFP36L1 during thymopoiesis lead to aberrant T cell development and subsequently develop a T-cell acute lymphoblastic leukemia (T-ALL) (PubMed:20622884). Show also higher levels of NOTCH1 mRNA and protein in thymocytes (PubMed:20622884). Conditional knockout mice of both ZFP36L2 and ZFP36L1 in pro-B cells display reduced B lymphocyte number and delayed variable-diversity-joining (VDJ) recombination (PubMed:27102483). Exhibit also increased protein and ARE-containing mRNA expressions of several factors implicated in cell cycle progression in late pre-B cells (PubMed:27102483). Sequence=AAA39709.1; Type=Erroneous gene model prediction; Evidence=; Sequence=AAA72946.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAA72946.1; Type=Frameshift; Evidence=; MAPK cascade nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay DNA binding RNA binding nucleus cytoplasm mRNA catabolic process multicellular organism development response to wounding hemopoiesis T cell differentiation in thymus somatic stem cell population maintenance mRNA 3'-UTR AU-rich region binding regulation of mRNA stability cellular response to fibroblast growth factor stimulus regulation of B cell differentiation negative regulation of fat cell differentiation metal ion binding somatic stem cell division definitive hemopoiesis 3'-UTR-mediated mRNA destabilization ERK1 and ERK2 cascade cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to glucocorticoid stimulus cellular response to transforming growth factor beta stimulus cellular response to granulocyte macrophage colony-stimulating factor stimulus positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of mitotic cell cycle phase transition negative regulation of stem cell differentiation uc008dsq.1 uc008dsq.2 uc008dsq.3 uc008dsq.4 uc008dsq.5 
ENSMUST00000060389.10 Rspry1 ENSMUST00000060389.10 ring finger and SPRY domain containing 1, transcript variant 1 (from RefSeq NM_026274.4) ENSMUST00000060389.1 ENSMUST00000060389.2 ENSMUST00000060389.3 ENSMUST00000060389.4 ENSMUST00000060389.5 ENSMUST00000060389.6 ENSMUST00000060389.7 ENSMUST00000060389.8 ENSMUST00000060389.9 Kiaa1972 NM_026274 Q3T9F1 Q3TM35 Q3U802 Q3UKF9 Q3UYN5 Q8BMH0 Q8BVR6 Q8C039 Q9CZ54 RSPRY_MOUSE uc009mwq.1 uc009mwq.2 uc009mwq.3 uc009mwq.4 Secreted Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BVR6-1; Sequence=Displayed; Name=2; IsoId=Q8BVR6-2; Sequence=VSP_023385, VSP_023386; Name=3; IsoId=Q8BVR6-3; Sequence=VSP_023384; Expressed in embryonic bone during primary endochondral ossification. Strong localization is observed in the perichondrium and periostium (at protein level). Also expressed in embryonic and postnatal brain and craniofacial tissues. Expressed in skeletal muscles (PubMed:26497270). Shows relatively low expression levels in proliferating myoblasts. Expression peaks at around day 1 of differentiation into myotubes and decreases again by day 10, when assayed in C2C12 cell line (at protein level). Up-regulated in response to denervation-induced skeletal muscle atrophy. Induced by MYOD1. Sequence=BAE22177.1; Type=Frameshift; Evidence=; ubiquitin-protein transferase activity extracellular region cytoplasm protein ubiquitination metal ion binding proteolysis involved in cellular protein catabolic process uc009mwq.1 uc009mwq.2 uc009mwq.3 uc009mwq.4 
ENSMUST00000060396.7 Slc25a46 ENSMUST00000060396.7 solute carrier family 25, member 46, transcript variant 1 (from RefSeq NM_026165.4) ENSMUST00000060396.1 ENSMUST00000060396.2 ENSMUST00000060396.3 ENSMUST00000060396.4 ENSMUST00000060396.5 ENSMUST00000060396.6 NM_026165 Q3TUD3 Q3UGG7 Q8VDX9 Q9CQS4 S2546_MOUSE Slc25a46 uc008ehz.1 uc008ehz.2 Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization. May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane. Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex. May associate with the endoplasmic reticulum membrane protein complex (EMC). Mitochondrion outer membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. molecular_function mitochondrion mitochondrial outer membrane membrane integral component of membrane mitochondrial membrane fission uc008ehz.1 uc008ehz.2 
ENSMUST00000060397.13 Rfx4 ENSMUST00000060397.13 regulatory factor X, 4 (influences HLA class II expression), transcript variant 1 (from RefSeq NM_001024918.1) B2RS52 ENSMUST00000060397.1 ENSMUST00000060397.10 ENSMUST00000060397.11 ENSMUST00000060397.12 ENSMUST00000060397.2 ENSMUST00000060397.3 ENSMUST00000060397.4 ENSMUST00000060397.5 ENSMUST00000060397.6 ENSMUST00000060397.7 ENSMUST00000060397.8 ENSMUST00000060397.9 NM_001024918 Q3V158 Q76KT2 Q7TNK1 Q8HWA6 Q9D453 RFX4_MOUSE uc007gkv.1 uc007gkv.2 uc007gkv.3 [Isoform 1]: Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development. May be required for neural tube ciliogenesis during embryogenesis (By similarity). Homodimer. Heterodimer with RFX2 and RFX3. Binds DNA (By similarity). Interacts with GPS2 (PubMed:18218630). Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=bRFX4, RFX4_v3; IsoId=Q7TNK1-1; Sequence=Displayed; Name=2; IsoId=Q7TNK1-2; Sequence=VSP_030248, VSP_030249; Name=3; IsoId=Q7TNK1-3; Sequence=VSP_030247; Name=4; IsoId=Q7TNK1-4; Sequence=VSP_030248, VSP_030249, VSP_030250, VSP_030251; Isoform 1: Brain-specific. Isoform 2: Testis- specific. Isoform 1: Highly expressed in the suprachiasmatic nucleus, the central pacemaker site of the circadian clock (at protein level). At 8.5 dpc, detected in most of the neural plate but is excluded from the presumptive forebrain region. At 9.5 dpc, its expression is mostly restricted to two large regions, the caudal diencephalon/mesencephalon and the spinal cord. By 10.5 dpc, is present throughout the neural tube, and it is also detected in the cerebral cortex. It is also strongly expressed in the developing subcommissural organ (SCO) from 14.5 dpc to birth. [Isoform 1]: Induced in a subjective night-specific manner. Mice with an insertion of a cardiac-specific epoxygenase transgene into an intron in the Rfx4 locus develop head swelling and rapid neurological decline in young adulthood, and have marked hydrocephalus of the lateral and third ventricles. Interruption of two alleles results in profound failure of dorsal midline brain structure formation and perinatal death. Interruption of a single allele prevents formation of the subcommissural organ, a structure important for cerebrospinal fluid flow through the aqueduct of Sylvius and results in congenital hydrocephalus. Belongs to the RFX family. Sequence=BAC28598.1; Type=Erroneous initiation; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter dorsal spinal cord development telencephalon development cerebellar cortex morphogenesis negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning forebrain development midbrain development positive regulation of transcription from RNA polymerase II promoter cilium assembly regulation of protein processing uc007gkv.1 uc007gkv.2 uc007gkv.3 
ENSMUST00000060417.11 Trp53i13 ENSMUST00000060417.11 transformation related protein 53 inducible protein 13 (from RefSeq NM_001024920.1) ENSMUST00000060417.1 ENSMUST00000060417.10 ENSMUST00000060417.2 ENSMUST00000060417.3 ENSMUST00000060417.4 ENSMUST00000060417.5 ENSMUST00000060417.6 ENSMUST00000060417.7 ENSMUST00000060417.8 ENSMUST00000060417.9 NM_001024920 P5I13_MOUSE Q5F267 Tp53i13 uc007kgz.1 uc007kgz.2 uc007kgz.3 May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed (By similarity). Cell membrane ; Single-pass type I membrane protein ; Extracellular side Cytoplasm Note=Associates with unknown subcellular structures in the cytoplasm. molecular_function cytoplasm plasma membrane response to UV response to organic cyclic compound membrane integral component of membrane response to drug negative regulation of cell cycle uc007kgz.1 uc007kgz.2 uc007kgz.3 
ENSMUST00000060418.8 Pnma3 ENSMUST00000060418.8 paraneoplastic antigen MA3 (from RefSeq NM_153169.2) ENSMUST00000060418.1 ENSMUST00000060418.2 ENSMUST00000060418.3 ENSMUST00000060418.4 ENSMUST00000060418.5 ENSMUST00000060418.6 ENSMUST00000060418.7 NM_153169 PNMA3_MOUSE Q3URF3 Q8JZW8 uc009tla.1 uc009tla.2 Nucleus, nucleolus Expressed in the cerebrum and cerebellum. Belongs to the PNMA family. molecular_function nucleic acid binding cellular_component nucleus nucleolus biological_process zinc ion binding metal ion binding uc009tla.1 uc009tla.2 
ENSMUST00000060427.6 Ier2 ENSMUST00000060427.6 immediate early response 2 (from RefSeq NM_010499.4) ENSMUST00000060427.1 ENSMUST00000060427.2 ENSMUST00000060427.3 ENSMUST00000060427.4 ENSMUST00000060427.5 IER2_MOUSE NM_010499 P17950 Q3TD12 Q64251 Q8BME8 Q99M25 uc009mmr.1 uc009mmr.2 uc009mmr.3 uc009mmr.4 DNA-binding protein that seems to act as a transcription factor (By similarity). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (By similarity). Cytoplasm Nucleus Note=Cytoplasmic during quiescence, translocates to the nucleus upon stimulation. By growth factors and cycloheximide. Belongs to the IER family. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus nucleoplasm cytoplasm neuron differentiation positive regulation of transcription from RNA polymerase II promoter cell motility response to fibroblast growth factor uc009mmr.1 uc009mmr.2 uc009mmr.3 uc009mmr.4 
ENSMUST00000060433.10 Tssc4 ENSMUST00000060433.10 Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus. Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing. Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP. (from UniProt Q9JHE7) AB038011 ENSMUST00000060433.1 ENSMUST00000060433.2 ENSMUST00000060433.3 ENSMUST00000060433.4 ENSMUST00000060433.5 ENSMUST00000060433.6 ENSMUST00000060433.7 ENSMUST00000060433.8 ENSMUST00000060433.9 MNCb-3063 Q9JHE7 TSSC4_MOUSE Tssc4 uc009kow.1 uc009kow.2 uc009kow.3 Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus. Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing. Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP. Interacts in a RNA-independent manner with distinct U5 snRNP- containing complexes, the mono-U5 snRNP and the post-splicing U5 snRNP- PRPF19 complex. Interacts with SNRNP200; the interaction is direct, excludes recruitment of C9ORF78 and WBP4 to SNRNP200 and negatively regulates its RNA helicase activity. Interacts with PRPF8; the interaction is direct. Nucleus Cytoplasm Note=Shuttles between the cytoplasm and the nucleus, associated with the U5 snRNP. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Tssc4-1; IsoId=Q9JHE7-1; Sequence=Displayed; Name=2; Synonyms=Tssc4-2; IsoId=Q9JHE7-2; Sequence=VSP_016562, VSP_016563; Expressed in placenta. Widely expressed in embryo and newborn. Expressed in embryo at 12.5 dpc and 16.5 dpc. Belongs to the TSSC4 family. cellular_component biological_process uc009kow.1 uc009kow.2 uc009kow.3 
ENSMUST00000060435.8 Selenon ENSMUST00000060435.8 selenoprotein N (from RefSeq NM_029100.2) D3Z2R5 ENSMUST00000060435.1 ENSMUST00000060435.2 ENSMUST00000060435.3 ENSMUST00000060435.4 ENSMUST00000060435.5 ENSMUST00000060435.6 ENSMUST00000060435.7 NM_029100 SELN_MOUSE Selenon Seln Sepn1 uc008vfk.1 uc008vfk.2 This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in the orthologous gene in human are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. Knockout mice deleted for this gene exhibit abnormal lung development. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. [provided by RefSeq, Dec 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (By similarity). Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290). Interacts with RYR1, RYR2 and RYR3. Endoplasmic reticulum membrane The N-terminus (first 61 amino acids) contains an endoplasmic reticulum addressing and retention targeting signal. N-glycosylated. Mutant mice show only subtle alterations in the muscle morphology, ultrastructure and contractility. They display increased muscle stress-sensitivity to physical exercise when performed under stress conditions such as a forced swimming test. Under these conditions, they develop muscle atrophy, predominantly affecting trunk muscles and leading to severe kyphosis (PubMed:21858002). The number of satellite cells in uninjured adult muscle is reduced. After one single cardiotoxin-induced injury, a correct restoration of the muscle fibers is seen in skeletal muscle, whereas after two successive injuries, regeneration is completely abolished (PubMed:21131290). respiratory system process molecular_function calcium ion binding endoplasmic reticulum endoplasmic reticulum membrane mitochondrion organization skeletal muscle satellite cell differentiation skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration positive regulation of skeletal muscle cell proliferation response to muscle activity involved in regulation of muscle adaptation membrane oxidoreductase activity multicellular organismal response to stress cellular response to oxidative stress skeletal muscle tissue regeneration lung alveolus development skeletal muscle fiber development calcium ion homeostasis oxidation-reduction process regulation of ryanodine-sensitive calcium-release channel activity cellular response to caffeine positive regulation of response to oxidative stress uc008vfk.1 uc008vfk.2 
ENSMUST00000060442.14 Gpr85 ENSMUST00000060442.14 G protein-coupled receptor 85, transcript variant 1 (from RefSeq NM_145066.5) ENSMUST00000060442.1 ENSMUST00000060442.10 ENSMUST00000060442.11 ENSMUST00000060442.12 ENSMUST00000060442.13 ENSMUST00000060442.2 ENSMUST00000060442.3 ENSMUST00000060442.4 ENSMUST00000060442.5 ENSMUST00000060442.6 ENSMUST00000060442.7 ENSMUST00000060442.8 ENSMUST00000060442.9 Gpr85 NM_145066 Q6ZWR2 Q6ZWR2_MOUSE uc009ays.1 uc009ays.2 uc009ays.3 uc009ays.4 Orphan receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity endoplasmic reticulum plasma membrane G-protein coupled receptor signaling pathway membrane integral component of membrane uc009ays.1 uc009ays.2 uc009ays.3 uc009ays.4 
ENSMUST00000060444.6 Zfp3 ENSMUST00000060444.6 zinc finger protein 3 (from RefSeq NM_177565.3) ENSMUST00000060444.1 ENSMUST00000060444.2 ENSMUST00000060444.3 ENSMUST00000060444.4 ENSMUST00000060444.5 NM_177565 Q8BLB0 ZFP3_MOUSE uc007jwo.1 uc007jwo.2 uc007jwo.3 uc007jwo.4 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding DNA binding cellular_component nucleus biological_process metal ion binding uc007jwo.1 uc007jwo.2 uc007jwo.3 uc007jwo.4 
ENSMUST00000060447.13 Mettl5 ENSMUST00000060447.13 methyltransferase 5, N6-adenosine, transcript variant 1 (from RefSeq NM_029280.4) ENSMUST00000060447.1 ENSMUST00000060447.10 ENSMUST00000060447.11 ENSMUST00000060447.12 ENSMUST00000060447.2 ENSMUST00000060447.3 ENSMUST00000060447.4 ENSMUST00000060447.5 ENSMUST00000060447.6 ENSMUST00000060447.7 ENSMUST00000060447.8 ENSMUST00000060447.9 METL5_MOUSE Mettl5 NM_029280 Q8K1A0 uc008jyv.1 uc008jyv.2 uc008jyv.3 uc008jyv.4 uc008jyv.5 Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:32783360, PubMed:35033535). N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (PubMed:32783360, PubMed:32217665). Reaction=adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:62612, Rhea:RHEA-COMP:16144, Rhea:RHEA-COMP:16145, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62613; Evidence=; rRNA N6-adenosine-methyltransferase activity is inhibited by zinc. Heterodimer; heterodimerizes with TRMT112. Nucleus Presynapse Postsynapse Ubiquitously expressed in brain. Mice were born at non-Mendelian rates and develop morphological, such as craniofacial abnormalities, snout deviation due to altered nasal bone development and incomplete fusion of the frontal bone suture (PubMed:32217665). Mice display reduced body size and evidence of metabolic defects (PubMed:35033535). Mice also show behavioral abnormalities (PubMed:32217665). Deletion in embryonic stem cells (ESCs) results in a decrease in global translation rate, spontaneous loss of pluripotency and compromised differentiation potential (PubMed:32783360, PubMed:32217665). Cells show abolished level of N6-methylation of adenine(1832) in 18S rRNA (PubMed:35033535). Belongs to the methyltransferase superfamily. PrmA family. Sequence=AAH27547.1; Type=Frameshift; Evidence=; nucleic acid binding cellular_component biological_process methyltransferase activity transferase activity methylation uc008jyv.1 uc008jyv.2 uc008jyv.3 uc008jyv.4 uc008jyv.5 
ENSMUST00000060455.15 Ccndbp1 ENSMUST00000060455.15 cyclin D-type binding-protein 1, transcript variant 3 (from RefSeq NR_185170.1) CCDB1_MOUSE Dip1 ENSMUST00000060455.1 ENSMUST00000060455.10 ENSMUST00000060455.11 ENSMUST00000060455.12 ENSMUST00000060455.13 ENSMUST00000060455.14 ENSMUST00000060455.2 ENSMUST00000060455.3 ENSMUST00000060455.4 ENSMUST00000060455.5 ENSMUST00000060455.6 ENSMUST00000060455.7 ENSMUST00000060455.8 ENSMUST00000060455.9 Gcip Maid NR_185170 Q3TVC7 Q3UMI3 Q61162 Q99JA7 Q99KG4 uc008lxg.1 uc008lxg.2 uc008lxg.3 May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription (By similarity). May be required for hepatocyte proliferation. Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TVC7-1; Sequence=Displayed; Name=2; IsoId=Q3TVC7-2; Sequence=VSP_032017; Name=3; IsoId=Q3TVC7-3; Sequence=VSP_032018; Expressed at high levels in brain, intestine, muscle and ovary and at lower levels in heart, kidney, liver, lung, spleen and testis. Highly expressed in the unfertilized egg. Expression is reduced at the two cell and blastocyst stages. Expressed in the liver, CNS and dorsal root ganglia throughout organogenesis. Also expressed in the intestine, kidney, lung, nasal cavities and thymus from 13 dpc. Expression is induced by partial hepatectomy. Phosphorylated. Belongs to the CCNDBP1 family. Sequence=AAB58118.1; Type=Frameshift; Evidence=; nucleus nucleoplasm cytoplasm cell cycle regulation of cell cycle uc008lxg.1 uc008lxg.2 uc008lxg.3 
ENSMUST00000060474.14 Septin6 ENSMUST00000060474.14 septin 6, transcript variant 2 (from RefSeq NM_019942.5) A2A3V9 A2A3W0 ENSMUST00000060474.1 ENSMUST00000060474.10 ENSMUST00000060474.11 ENSMUST00000060474.12 ENSMUST00000060474.13 ENSMUST00000060474.2 ENSMUST00000060474.3 ENSMUST00000060474.4 ENSMUST00000060474.5 ENSMUST00000060474.6 ENSMUST00000060474.7 ENSMUST00000060474.8 ENSMUST00000060474.9 Kiaa0128 NM_019942 Q3TRH9 Q3TUA2 Q542H3 Q6A0C4 Q8C2L2 Q8C848 Q91XH2 Q9CZ94 Q9R1T4 SEPT6_MOUSE Sept6 Septin6 uc009sxx.1 uc009sxx.2 uc009sxx.3 uc009sxx.4 Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPTIN2, SEPTIN6 and SEPTIN7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPTIN2 and SEPTIN7. Also interacts with SEPTIN9 and SEPTIN12. Interaction with SEPTIN12 alters filament structure. Component of a septin core octameric complex consisting of SEPTIN12, SEPTIN7, SEPTIN6 and SEPTIN2 or SEPTIN4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6- 7-12 and located in the sperm annulus. Interacts with SOCS7. Interacts with HNRNPA1 (By similarity). Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore Cleavage furrow Midbody Cell projection, cilium, flagellum Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Found in the sperm annulus (By similarity). Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=II; IsoId=Q9R1T4-1; Sequence=Displayed; Name=I; Synonyms=III; IsoId=Q9R1T4-2; Sequence=VSP_006055; Name=V; IsoId=Q9R1T4-3; Sequence=VSP_006056; Expressed in the cerebral cortex (at protein level) (PubMed:20181826). Associated with synaptic vesicles in various brain regions, including glomeruli of the olfactory bulb (at protein level) (PubMed:11064363). Coordinated expression with SEPT2 and SEPT7. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. Sequence=BAD32172.1; Type=Erroneous initiation; Evidence=; Sequence=CAM19782.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding chromosome, centromeric region kinetochore condensed chromosome kinetochore GTPase activity protein binding GTP binding chromosome cytoplasm spindle cytoskeleton cilium septin ring cell cycle spermatogenesis synaptic vesicle microtubule cytoskeleton cell differentiation midbody septin complex motile cilium cleavage furrow septin collar cell projection axon terminus cell division cilium assembly cytoskeleton-dependent cytokinesis sperm annulus presynapse uc009sxx.1 uc009sxx.2 uc009sxx.3 uc009sxx.4 
ENSMUST00000060479.14 Ush2a ENSMUST00000060479.14 usherin (from RefSeq NM_021408.3) E9QLJ9 ENSMUST00000060479.1 ENSMUST00000060479.10 ENSMUST00000060479.11 ENSMUST00000060479.12 ENSMUST00000060479.13 ENSMUST00000060479.2 ENSMUST00000060479.3 ENSMUST00000060479.4 ENSMUST00000060479.5 ENSMUST00000060479.6 ENSMUST00000060479.7 ENSMUST00000060479.8 ENSMUST00000060479.9 Gm676 NM_021408 Q2QI47 Q9JLP3 USH2A_MOUSE Ush2A uc007eaf.1 uc007eaf.2 uc007eaf.3 uc007eaf.4 Involved in hearing and vision as member of the USH2 complex (PubMed:20502675). In the inner ear, required for the maintenance of hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells (PubMed:20502675, PubMed:24334608). In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport (PubMed:20502675). Interacts with collagen IV and fibronectin via its laminin EGF-like domains. Interaction with collagen may be required for stable integration into the basement membrane. Interacts with NINL (By similarity). Interacts with USH1C (PubMed:16301217). Component of USH2 complex, composed of ADGRV1, PDZD7, USH2A and WHRN (PubMed:20502675, PubMed:25406310). Interacts with ADGRV1/MASS1 (via N-terminal PDZ domain) (PubMed:20502675). Interacts (via the cytoplasmic region) with WHRN (PubMed:16301217, PubMed:20502675, PubMed:23055499). Interacts (via the cytoplasmic region) with PDZD7 (PubMed:23055499). Interacts (via the cytoplasmic region) with VEZT and MYO7A (via MyTH4-FERM domains); the interaction associates VEZT with the USH2 complex at the stereocilia base (PubMed:17567809). Cell projection, stereocilium membrane ingle-pass type I membrane protein. Photoreceptor inner segment te=Component of the interstereocilia ankle links in the inner ear sensory cells (PubMed:20502675, PubMed:24334608). In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment that surrounds the connecting cilia called periciliary membrane complex (PubMed:20502675, PubMed:24334608). [Isoform 2]: Secreted. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q2QI47-1; Sequence=Displayed; Name=2; IsoId=Q2QI47-2; Sequence=VSP_017774, VSP_017775; Name=3; IsoId=Q2QI47-3; Sequence=VSP_017776; Present in the testis, epididymis, oviduct, spleen, submaxillary gland, and small and large intestines. Not detected in the brain, skin, lung, skeletal muscle, cardiac muscle, liver or kidney. Expressed in smooth muscle of the colon and the epididymis. Also present in select vascular basement membranes. In the cochlea, it is present in virtually every basement membrane. It is particularly high in the strial capillary basement membranes (SCBMs). In the retina, it is again expressed in all of the basement membranes. It is also very prevalent in the lens capsule and the Bruch's layer between the retinal pigment epithelium and the choroid layer, which is very rich in basement membranes. In neonates in it is widely expressed in the basement membranes of the cochlea. Present in the synaptic terminals of retinal photoreceptors (at protein level). The PDZ-binding motif mediates the association with some of the PDZ domains of USH1C and WHRN. photoreceptor inner segment stereocilia ankle link stereocilia ankle link complex protein binding collagen binding extracellular region basement membrane cytoplasm plasma membrane visual perception sensory perception of sound animal organ morphogenesis tissue development membrane integral component of membrane apical plasma membrane myosin binding photoreceptor connecting cilium stereocilium stereocilium bundle hair cell differentiation ciliary basal body protein homodimerization activity cell projection establishment of protein localization synapse photoreceptor cell maintenance maintenance of animal organ identity response to stimulus sensory perception of light stimulus inner ear receptor cell differentiation stereocilium membrane periciliary membrane compartment USH2 complex neuronal cell body terminal bouton uc007eaf.1 uc007eaf.2 uc007eaf.3 uc007eaf.4 
ENSMUST00000060481.9 Dcaf12l1 ENSMUST00000060481.9 DDB1 and CUL4 associated factor 12-like 1, transcript variant A (from RefSeq NM_178739.6) DC121_MOUSE ENSMUST00000060481.1 ENSMUST00000060481.2 ENSMUST00000060481.3 ENSMUST00000060481.4 ENSMUST00000060481.5 ENSMUST00000060481.6 ENSMUST00000060481.7 ENSMUST00000060481.8 NM_178739 Q6NV47 Q8C8E2 Q8CA30 Q8CAL3 Q8CBW4 Q8CBX8 Wdr40b uc009tbg.1 uc009tbg.2 uc009tbg.3 uc009tbg.4 Belongs to the WD repeat DCAF12 family. It is uncertain whether Met-1 or Met-31 is the initiator. Sequence=BAC28681.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process Cul4-RING E3 ubiquitin ligase complex uc009tbg.1 uc009tbg.2 uc009tbg.3 uc009tbg.4 
ENSMUST00000060484.9 Clec4a1 ENSMUST00000060484.9 C-type lectin domain family 4, member a1 (from RefSeq NM_199311.2) BC049354 Clec4a1 Dcir4 ENSMUST00000060484.1 ENSMUST00000060484.2 ENSMUST00000060484.3 ENSMUST00000060484.4 ENSMUST00000060484.5 ENSMUST00000060484.6 ENSMUST00000060484.7 ENSMUST00000060484.8 NM_199311 Q80UI7 Q80UI7_MOUSE uc009dpu.1 uc009dpu.2 uc009dpu.3 molecular_function cellular_component biological_process membrane integral component of membrane carbohydrate binding uc009dpu.1 uc009dpu.2 uc009dpu.3 
ENSMUST00000060490.11 Homer1 ENSMUST00000060490.11 homer scaffolding protein 1, transcript variant b (from RefSeq NM_001284189.2) ENSMUST00000060490.1 ENSMUST00000060490.10 ENSMUST00000060490.2 ENSMUST00000060490.3 ENSMUST00000060490.4 ENSMUST00000060490.5 ENSMUST00000060490.6 ENSMUST00000060490.7 ENSMUST00000060490.8 ENSMUST00000060490.9 HOME1_MOUSE Homer1 NM_001284189 Q8K3E1 Q8K4M8 Q9Z0E9 Q9Z216 Q9Z2Y3 Vesl1 uc007rld.1 uc007rld.2 uc007rld.3 uc007rld.4 uc007rld.5 Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 5 counteracts the effects by competing for binding sites. Isoform 3 regulates the trafficking and surface expression of GRM5. Isoform 5 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, isoform 2 and isoform 3 to regulate synaptic metabotropic glutamate function. Isoform 5, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development (By similarity). Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity). Tetramer; this tetrameric structure is critical for forming the high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Isoform 1, isoform 2 and isoform 3 encode a coiled-coil structure that mediates homo- and heteromultimerization (By similarity). Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2 and SHANK3 (PubMed:12379179, PubMed:21558424, PubMed:24153177). Interacts with IFT57 and OPHN1 (PubMed:17107665). Interacts with SHANK1; forms high-order polymerized complex with a mesh-like network structure, at least composed of SHANK1, HOMER1 and DLGAP1; the complex formation is SHANK1 multimerization dependent (By similarity). Interacts with NFATC4 (By similarity). Interacts with DAGLA (via PPXXF motif); this interaction is required for the cell membrane localization of DAGLA (By similarity). Interacts with SRGAP2 (PubMed:27373832). Q9Z2Y3; Q9D415: Dlgap1; NbExp=4; IntAct=EBI-396980, EBI-400152; Q9Z2Y3; Q4ACU6: Shank3; NbExp=8; IntAct=EBI-396980, EBI-771450; Cytoplasm Postsynaptic density Synapse Cell projection, dendritic spine Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. The N-terminal of isoform 2 may facilitate trafficking of the complex with GRM5 from the endoplasmic reticulum (ER) to the plasma membrane (PM). Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Vesl-1L; IsoId=Q9Z2Y3-1; Sequence=Displayed; Name=2; Synonyms=1d; IsoId=Q9Z2Y3-2; Sequence=VSP_009060, VSP_009061; Name=3; Synonyms=1b; IsoId=Q9Z2Y3-3; Sequence=VSP_009061; Name=4; Synonyms=Vesl-1M; IsoId=Q9Z2Y3-4; Sequence=VSP_009063, VSP_009065; Name=5; Synonyms=Vesl-1S; IsoId=Q9Z2Y3-5; Sequence=VSP_009062, VSP_009064; Isoform 1, isoform 3 and isoform 5 are expressed in skeletal muscle at the level of the Z line, in heart, forebrain and cerebellum. Isoform 2, is a minor isoform and is expressed in cardiac and skeletal muscle. Isoform 5 is expressed in the postsynaptic region of neurons. The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3. The coiled-Coil domain forms an antiparallel tetrameric arrangement (By similarity). Belongs to the Homer family. skeletal muscle contraction receptor binding protein binding cytoplasm plasma membrane G-protein coupled glutamate receptor signaling pathway postsynaptic density membrane Z disc cell junction axon dendrite type 5 metabotropic glutamate receptor binding G-protein coupled glutamate receptor binding protein localization to synapse identical protein binding cell projection neuron projection neuronal cell body costamere dendritic spine dendritic shaft neuron spine ion channel binding apical part of cell synapse postsynaptic membrane protein heterodimerization activity behavioral response to cocaine skeletal muscle fiber development chemical homeostasis within a tissue protein tetramerization response to calcium ion positive regulation of calcium ion transport regulation of synaptic transmission, glutamatergic binding, bridging regulation of calcium ion import scaffold protein binding postsynapse regulation of postsynaptic neurotransmitter receptor activity glutamatergic synapse postsynaptic cytosol regulation of dendritic spine maintenance regulation of store-operated calcium entry regulation of cation channel activity excitatory synapse uc007rld.1 uc007rld.2 uc007rld.3 uc007rld.4 uc007rld.5 
ENSMUST00000060494.8 Krtap13-1 ENSMUST00000060494.8 keratin associated protein 13-1 (from RefSeq NM_183189.1) ENSMUST00000060494.1 ENSMUST00000060494.2 ENSMUST00000060494.3 ENSMUST00000060494.4 ENSMUST00000060494.5 ENSMUST00000060494.6 ENSMUST00000060494.7 Krtap13-1 NM_183189 Q8K198 Q8K198_MOUSE uc007zvb.1 uc007zvb.2 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the PMG family. molecular_function cellular_component intermediate filament biological_process uc007zvb.1 uc007zvb.2 
ENSMUST00000060500.9 Eif5a2 ENSMUST00000060500.9 eukaryotic translation initiation factor 5A2 (from RefSeq NM_177586.6) ENSMUST00000060500.1 ENSMUST00000060500.2 ENSMUST00000060500.3 ENSMUST00000060500.4 ENSMUST00000060500.5 ENSMUST00000060500.6 ENSMUST00000060500.7 ENSMUST00000060500.8 IF5A2_MOUSE NM_177586 Q8BGY2 uc008oud.1 uc008oud.2 uc008oud.3 Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). Binds to 80S ribosomes. Actively translating ribosomes show mutually exclusive binding of eIF5a (EIF5A or EIF5A2) and EEF2/eEF2 (By similarity). Interacts with DAPL1; interaction takes place at the polypeptide exit tunnel of hibernating ribosomes and prevents translation (By similarity). Cytoplasm Nucleus Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. Lys-50 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain and leads to the formation of a hypusine residue. eIF-5As are the only known proteins to undergo this modification, which is essential for their function. Belongs to the eIF-5A family. RNA binding translation elongation factor activity nucleus nuclear pore cytoplasm endoplasmic reticulum endoplasmic reticulum membrane translation translational elongation translational frameshifting positive regulation of cell proliferation protein transport membrane ribosome binding intracellular membrane-bounded organelle positive regulation of translational elongation positive regulation of translational termination mRNA transport uc008oud.1 uc008oud.2 uc008oud.3 
ENSMUST00000060501.5 Cdkn2a ENSMUST00000060501.5 cyclin dependent kinase inhibitor 2A, transcript variant 2 (from RefSeq NM_001040654.1) A2ANM1 A2ANM2 CDN2A_MOUSE Cdkn2a ENSMUST00000060501.1 ENSMUST00000060501.2 ENSMUST00000060501.3 ENSMUST00000060501.4 NM_001040654 O89088 P16ink4a P51480 P97510 P97937 Q6PEA2 Q78E39 Q78E57 Q792X7 Q9QWH6 Q9QWH7 Q9QWH8 uc008toh.1 uc008toh.2 uc008toh.3 Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. Heterodimer with CDK4 or CDK6. Predominamt P16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2 (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=4; Comment=Isoform 1 and isoform tumor suppressor ARF arise due to the use of two alternative first exons joined to a common exon 2 at the same acceptor site but in different reading frames, resulting in two completely different isoforms.; Name=1; Synonyms=p16INK4a; IsoId=P51480-1; Sequence=Displayed; Name=2; IsoId=P51480-2; Sequence=VSP_015867; Name=tumor suppressor ARF; Synonyms=p19ARF; IsoId=Q64364-1; Sequence=External; Name=smARF; IsoId=Q64364-2; Sequence=External; Phosphorylation seems to increase interaction with CDK4. Strain BALB/c displays a significantly reduced ability to inhibit phosphorylation of the retinoblastoma protein. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. The proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to tumor suppressor ARF (AC Q64364) which is encoded by the same gene. regulation of cyclin-dependent protein serine/threonine kinase activity G1/S transition of mitotic cell cycle protein polyubiquitination mitophagy negative regulation of cell-matrix adhesion p53 binding cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding nucleus nucleoplasm nucleolus cytoplasm mitochondrion negative regulation of protein kinase activity activation of cysteine-type endopeptidase activity involved in apoptotic process cell cycle cell cycle arrest aging cell aging transcription factor binding negative regulation of cell proliferation epidermis development apoptotic mitochondrial changes rRNA transcription response to organonitrogen compound regulation of G2/M transition of mitotic cell cycle regulation of gene expression positive regulation of gene expression response to organic cyclic compound protein sumoylation SUMO transferase activity protein kinase binding negative regulation of cell growth protein destabilization negative regulation of NF-kappaB transcription factor activity negative regulation of protein binding macromolecular complex positive regulation of protein sumoylation negative regulation of mammary gland epithelial cell proliferation positive regulation of smooth muscle cell apoptotic process somatic stem cell population maintenance senescence-associated heterochromatin focus senescence-associated heterochromatin focus assembly negative regulation of phosphorylation response to drug glucose homeostasis positive regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of nucleocytoplasmic transport regulation of protein export from nucleus protein N-terminus binding protein stabilization NF-kappaB binding regulation of sequence-specific DNA binding transcription factor activity mitochondrial depolarization positive regulation of apoptotic process involved in mammary gland involution cellular response to hydrogen peroxide protein K63-linked ubiquitination positive regulation of cell cycle arrest cellular senescence replicative senescence MDM2/MDM4 family protein binding disordered domain specific binding positive regulation of protein localization to nucleus positive regulation of signal transduction by p53 class mediator regulation of apoptotic DNA fragmentation negative regulation of proteolysis involved in cellular protein catabolic process regulation of protein targeting to mitochondrion negative regulation of ubiquitin protein ligase activity amyloid fibril formation ubiquitin ligase inhibitor activity negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of macrophage apoptotic process negative regulation of hepatocyte proliferation negative regulation of protein neddylation positive regulation of cellular senescence nuclear body uc008toh.1 uc008toh.2 uc008toh.3 
ENSMUST00000060513.8 Acad8 ENSMUST00000060513.8 acyl-Coenzyme A dehydrogenase family, member 8 (from RefSeq NM_025862.2) A0A0R4J0P1 A0A0R4J0P1_MOUSE Acad8 ENSMUST00000060513.1 ENSMUST00000060513.2 ENSMUST00000060513.3 ENSMUST00000060513.4 ENSMUST00000060513.5 ENSMUST00000060513.6 ENSMUST00000060513.7 NM_025862 uc009opy.1 uc009opy.2 uc009opy.3 uc009opy.4 uc009opy.5 Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Belongs to the acyl-CoA dehydrogenase family. acyl-CoA dehydrogenase activity lipid metabolic process oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors flavin adenine dinucleotide binding oxidation-reduction process uc009opy.1 uc009opy.2 uc009opy.3 uc009opy.4 uc009opy.5 
ENSMUST00000060522.11 Oc90 ENSMUST00000060522.11 otoconin 90, transcript variant 1 (from RefSeq NM_010953.3) ENSMUST00000060522.1 ENSMUST00000060522.10 ENSMUST00000060522.2 ENSMUST00000060522.3 ENSMUST00000060522.4 ENSMUST00000060522.5 ENSMUST00000060522.6 ENSMUST00000060522.7 ENSMUST00000060522.8 ENSMUST00000060522.9 NM_010953 OC90_MOUSE Oc90 Onc-95 Pla2ll Q9CZ60 Q9Z0L3 Q9Z225 uc007vzx.1 uc007vzx.2 uc007vzx.3 uc007vzx.4 Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear (PubMed:17300776). Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure (PubMed:21655225, PubMed:24748133). Together with OTOL1, modulates calcite crystal morphology and growth kinetics (PubMed:24748133). It is unlikely that this protein has phospholipase A2 activity (PubMed:17300776). Interacts with OTOL1. Secreted Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9Z0L3-1; Sequence=Displayed; Name=2; IsoId=Q9Z0L3-2; Sequence=VSP_004510; Name=3; IsoId=Q9Z0L3-3; Sequence=VSP_004511, VSP_004513; Name=4; IsoId=Q9Z0L3-4; Sequence=VSP_004515; Name=5; IsoId=Q9Z0L3-5; Sequence=VSP_004512, VSP_004514; In the embryo, highly expressed in the developing otocyst with weak expression in the brain. Also expressed in nonsensory epithelia of both the vestibular and cochlear portions of the developing inner ear. Not expressed in adult or embryonic macular sensory epithelia. Expressed from embryonic day 9.5. Consists of 3 PA2-type domains. Otoconia show a strongly reduced matrix-calcium. Belongs to the phospholipase A2 family. phospholipase A2 activity structural molecule activity calcium ion binding protein binding phospholipid binding extracellular region phospholipid metabolic process lipid catabolic process extracellular matrix otolith mineralization metal ion binding calcium-dependent phospholipase A2 activity arachidonic acid secretion uc007vzx.1 uc007vzx.2 uc007vzx.3 uc007vzx.4 
ENSMUST00000060524.11 Trim10 ENSMUST00000060524.11 tripartite motif-containing 10, transcript variant 2 (from RefSeq NM_011280.2) ENSMUST00000060524.1 ENSMUST00000060524.10 ENSMUST00000060524.2 ENSMUST00000060524.3 ENSMUST00000060524.4 ENSMUST00000060524.5 ENSMUST00000060524.6 ENSMUST00000060524.7 ENSMUST00000060524.8 ENSMUST00000060524.9 Herf1 NM_011280 Q80WA9 Q9CY03 Q9WUH5 Rnf9 TRI10_MOUSE uc008clj.1 uc008clj.2 uc008clj.3 E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells (PubMed:18560381). May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (PubMed:32343488). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (By similarity). Interacts with IFNAR1; this interaction prevents association of IFNAR1 with TYK2. Cytoplasm Expressed in embryonic liver. Deletion mice inhibit hypertrophic remodeling after transverse aortic constriction surgery. Belongs to the TRIM/RBCC family. protein binding cytoplasm zinc ion binding erythrocyte differentiation innate immune response negative regulation of viral entry into host cell metal ion binding uc008clj.1 uc008clj.2 uc008clj.3 
ENSMUST00000060526.11 Gm5087 ENSMUST00000060526.11 predicted gene 5087, transcript variant 1 (from RefSeq NR_121588.1) ENSMUST00000060526.1 ENSMUST00000060526.10 ENSMUST00000060526.2 ENSMUST00000060526.3 ENSMUST00000060526.4 ENSMUST00000060526.5 ENSMUST00000060526.6 ENSMUST00000060526.7 ENSMUST00000060526.8 ENSMUST00000060526.9 NR_121588 uc007sfx.1 uc007sfx.2 uc007sfx.3 uc007sfx.1 uc007sfx.2 uc007sfx.3 
ENSMUST00000060531.16 Lrrc8d ENSMUST00000060531.16 leucine rich repeat containing 8D, transcript variant 1 (from RefSeq NM_001122768.1) ENSMUST00000060531.1 ENSMUST00000060531.10 ENSMUST00000060531.11 ENSMUST00000060531.12 ENSMUST00000060531.13 ENSMUST00000060531.14 ENSMUST00000060531.15 ENSMUST00000060531.2 ENSMUST00000060531.3 ENSMUST00000060531.4 ENSMUST00000060531.5 ENSMUST00000060531.6 ENSMUST00000060531.7 ENSMUST00000060531.8 ENSMUST00000060531.9 LRC8D_MOUSE Lrrc5 Lrrc8d NM_001122768 Q3UVA9 Q8BGR2 Q8CI13 uc008ylg.1 uc008ylg.2 uc008ylg.3 Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29773801). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29773801). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324, ChEBI:CHEBI:16382; Evidence=; Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328, ChEBI:CHEBI:507393; Evidence=; Heterohexamer (Probable). Oligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8E) to form a heterohexamer. In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (PubMed:24782309). Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:29773801). Requires LRRC8A for expression at the cell membrane (By similarity). Expressed in pancreatic beta cells (PubMed:29773801). Also expressed in glucagon-secreting pancreatic alpha cells (PubMed:29773801). The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins. Belongs to the LRRC8 family. volume-sensitive anion channel activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane ion transport inorganic anion transport taurine transport aspartate transport membrane integral component of membrane ion channel complex cellular response to osmotic stress anion transmembrane transport uc008ylg.1 uc008ylg.2 uc008ylg.3 
ENSMUST00000060537.13 Kif1b ENSMUST00000060537.13 kinesin family member 1B, transcript variant 3 (from RefSeq NM_001290995.1) ENSMUST00000060537.1 ENSMUST00000060537.10 ENSMUST00000060537.11 ENSMUST00000060537.12 ENSMUST00000060537.2 ENSMUST00000060537.3 ENSMUST00000060537.4 ENSMUST00000060537.5 ENSMUST00000060537.6 ENSMUST00000060537.7 ENSMUST00000060537.8 ENSMUST00000060537.9 KIF1B_MOUSE NM_001290995 Q60575 Q9R0B4 Q9WVE5 Q9Z119 uc008vvz.1 uc008vvz.2 uc008vvz.3 uc008vvz.4 Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 1 mediates the transport of synaptic vesicles in neuronal cells. Monomer (PubMed:7528108). Interacts with KIFBP (By similarity). Interacts (via C-terminus end of the kinesin-motor domain) with CHP1; the interaction occurs in a calcium-dependent manner (By similarity). Interacts with MADD (via death domain) (PubMed:18849981). Cytoplasm, cytoskeleton. Mitochondrion Cell projection, axon [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q60575-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q60575-2; Sequence=VSP_002862, VSP_002863; Name=3; IsoId=Q60575-3; Sequence=VSP_002862, VSP_002863, VSP_002864, VSP_002865; Expressed in the brain (at protein level). Reduced Rab3 and Madd levels in distal axons of hippocampal neurons. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. nucleotide binding microtubule motor activity protein binding ATP binding cytoplasm mitochondrion cytoskeleton kinesin complex microtubule microtubule associated complex microtubule-based movement neuron-neuron synaptic transmission neuromuscular synaptic transmission microtubule binding anterograde axonal transport ATP-dependent microtubule motor activity, plus-end-directed embryo development ending in birth or egg hatching positive regulation of gene expression transport along microtubule membrane vesicle-mediated transport ATPase activity kinase binding axon dendrite cytoplasmic vesicle membrane cytoskeleton-dependent intracellular transport cytoplasmic vesicle lysosome localization neuron projection mitochondrion transport along microtubule scaffold protein binding axon cytoplasm response to rotenone anterograde neuronal dense core vesicle transport retrograde neuronal dense core vesicle transport cellular response to nerve growth factor stimulus protein localization to cell periphery ATP-dependent microtubule motor activity uc008vvz.1 uc008vvz.2 uc008vvz.3 uc008vvz.4 
ENSMUST00000060551.9 Apol10a ENSMUST00000060551.9 apolipoprotein L 10A (from RefSeq NM_177744.4) Apol10a ENSMUST00000060551.1 ENSMUST00000060551.2 ENSMUST00000060551.3 ENSMUST00000060551.4 ENSMUST00000060551.5 ENSMUST00000060551.6 ENSMUST00000060551.7 ENSMUST00000060551.8 NM_177744 Q8CCA5 Q8CCA5_MOUSE uc007wnr.1 uc007wnr.2 Belongs to the apolipoprotein L family. cellular_component extracellular region lipid transport biological_process lipid binding lipoprotein metabolic process uc007wnr.1 uc007wnr.2 
ENSMUST00000060561.15 Fam221a ENSMUST00000060561.15 family with sequence similarity 221, member A, transcript variant 1 (from RefSeq NM_172727.3) ENSMUST00000060561.1 ENSMUST00000060561.10 ENSMUST00000060561.11 ENSMUST00000060561.12 ENSMUST00000060561.13 ENSMUST00000060561.14 ENSMUST00000060561.2 ENSMUST00000060561.3 ENSMUST00000060561.4 ENSMUST00000060561.5 ENSMUST00000060561.6 ENSMUST00000060561.7 ENSMUST00000060561.8 ENSMUST00000060561.9 F221A_MOUSE NM_172727 Q7TML5 Q8C790 uc009bwr.1 uc009bwr.2 uc009bwr.3 uc009bwr.4 uc009bwr.5 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C790-1; Sequence=Displayed; Name=2; IsoId=Q8C790-2; Sequence=VSP_026740, VSP_026741; Belongs to the FAM221 family. molecular_function cellular_component biological_process uc009bwr.1 uc009bwr.2 uc009bwr.3 uc009bwr.4 uc009bwr.5 
ENSMUST00000060574.9 A2ml1 ENSMUST00000060574.9 alpha-2-macroglobulin like 1 (from RefSeq NM_001001179.3) E9QMV5 ENSMUST00000060574.1 ENSMUST00000060574.2 ENSMUST00000060574.3 ENSMUST00000060574.4 ENSMUST00000060574.5 ENSMUST00000060574.6 ENSMUST00000060574.7 ENSMUST00000060574.8 NM_001001179 OVOS_MOUSE Ovos Q3UU35 uc009eeh.1 uc009eeh.2 uc009eeh.3 uc009eeh.4 Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. Homotetramer. Secreted Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity cellular_component extracellular region extracellular space negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc009eeh.1 uc009eeh.2 uc009eeh.3 uc009eeh.4 
ENSMUST00000060576.8 Lpar4 ENSMUST00000060576.8 lysophosphatidic acid receptor 4 (from RefSeq NM_175271.4) A2ADM5 ENSMUST00000060576.1 ENSMUST00000060576.2 ENSMUST00000060576.3 ENSMUST00000060576.4 ENSMUST00000060576.5 ENSMUST00000060576.6 ENSMUST00000060576.7 Gpr23 LPAR4_MOUSE Lpa4 NM_175271 P2y9 Q8BKK1 Q8BLG2 Q8VE54 uc009ubx.1 uc009ubx.2 uc009ubx.3 uc009ubx.4 Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1- oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1- alkenyl-LPA (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway lipid binding membrane integral component of membrane nuclear body positive regulation of Rho protein signal transduction lysophosphatidic acid binding intracellular membrane-bounded organelle positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway lysophosphatidic acid receptor activity uc009ubx.1 uc009ubx.2 uc009ubx.3 uc009ubx.4 
ENSMUST00000060579.10 Mgat2 ENSMUST00000060579.10 mannoside acetylglucosaminyltransferase 2 (from RefSeq NM_146035.2) ENSMUST00000060579.1 ENSMUST00000060579.2 ENSMUST00000060579.3 ENSMUST00000060579.4 ENSMUST00000060579.5 ENSMUST00000060579.6 ENSMUST00000060579.7 ENSMUST00000060579.8 ENSMUST00000060579.9 MGAT2_MOUSE NM_146035 Q3U6X4 Q8C3Z6 Q921V5 uc011ymy.1 uc011ymy.2 uc011ymy.3 Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans. Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- (1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L- asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)- alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D- GlcNAc}-L-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:12941, Rhea:RHEA-COMP:13526, Rhea:RHEA-COMP:14369, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:60615, ChEBI:CHEBI:60651; EC=2.4.1.143; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Homodimer. Golgi apparatus membrane ; Single-pass type II membrane protein Detected in liver, lung, testis, kidney, brain, spleen, thymus, uterus and intestine. Decreased embryonic survival between 9 and 15 dpc. Surviving embryos are about 20% smaller than their littermates by 15 dpc. Most of the newborn pups die during the first week after birth, and none live longer than 4 weeks. Pups are about half the size of their littermates 8 days after birth, have dismorphic facial features and severe locomotor deficits. Pups display impaired muscle development and defects in bone development including a hunched spinal column, plus poorly calcified and brittle bones in vertebrae, ribs, femur and skull. Mutant mice have also mild anemia and impaired mucus production in the gastrointestinal system. Outcrossing increases the length of the lifespan, but does not increase the number of pups that survive after the fist week. Surviving males display testicular atrophy and are infertile. About one third of the surviving females produce offspring, but do not nurture their pups. Belongs to the glycosyltransferase 16 (GT16) protein family. Golgi membrane Golgi apparatus Golgi stack protein glycosylation protein N-linked glycosylation alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity oligosaccharide biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein N-linked glycosylation via asparagine manganese ion binding carbohydrate binding protein homodimerization activity metal ion binding uc011ymy.1 uc011ymy.2 uc011ymy.3 
ENSMUST00000060587.4 Defb13 ENSMUST00000060587.4 defensin beta 13 (from RefSeq NM_139223.5) A2A4E3 DFB13_MOUSE ENSMUST00000060587.1 ENSMUST00000060587.2 ENSMUST00000060587.3 NM_139223 Q8R2I4 uc009lcg.1 uc009lcg.2 uc009lcg.3 Has antibacterial activity. Secreted Expressed in testis and to a lesser extent in epididymis (caput, corpus and cauda). Also weakly expressed in kidneys. Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium uc009lcg.1 uc009lcg.2 uc009lcg.3 
ENSMUST00000060598.4 Defb29 ENSMUST00000060598.4 defensin beta 29 (from RefSeq NM_001001444.2) DFB29_MOUSE ENSMUST00000060598.1 ENSMUST00000060598.2 ENSMUST00000060598.3 NM_001001444 Q8BGW9 uc008nfq.1 uc008nfq.2 uc008nfq.3 Has antibacterial activity. Secreted Highly expressed in the cauda epididymis. Belongs to the beta-defensin family. extracellular region defense response defense response to bacterium innate immune response uc008nfq.1 uc008nfq.2 uc008nfq.3 
ENSMUST00000060608.13 Cyp20a1 ENSMUST00000060608.13 cytochrome P450, family 20, subfamily a, polypeptide 1, transcript variant 1 (from RefSeq NM_030013.3) CP20A_MOUSE ENSMUST00000060608.1 ENSMUST00000060608.10 ENSMUST00000060608.11 ENSMUST00000060608.12 ENSMUST00000060608.2 ENSMUST00000060608.3 ENSMUST00000060608.4 ENSMUST00000060608.5 ENSMUST00000060608.6 ENSMUST00000060608.7 ENSMUST00000060608.8 ENSMUST00000060608.9 NM_030013 Q8BKE6 uc007ben.1 uc007ben.2 uc007ben.3 uc007ben.4 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Membrane ; Single-pass membrane protein Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc007ben.1 uc007ben.2 uc007ben.3 uc007ben.4 
ENSMUST00000060642.7 Lrrk2 ENSMUST00000060642.7 leucine-rich repeat kinase 2 (from RefSeq NM_025730.3) E9QNJ2 ENSMUST00000060642.1 ENSMUST00000060642.2 ENSMUST00000060642.3 ENSMUST00000060642.4 ENSMUST00000060642.5 ENSMUST00000060642.6 LRRK2_MOUSE NM_025730 Q5S006 Q8BWG7 Q8BZJ6 Q8CI84 Q8K062 uc007xhz.1 uc007xhz.2 uc007xhz.3 Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:30398148, PubMed:29212815). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:30398148, PubMed:29212815, PubMed:29125462). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PubMed:26824392, PubMed:28720718, PubMed:30398148, PubMed:29212815). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (By similarity). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (By similarity). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (By similarity). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (By similarity). Phosphorylates PRDX3 (By similarity). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (By similarity). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (By similarity). In addition, has GTPase activity via its Roc domain which regulates LRKK2 kinase activity (By similarity). Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Kinase activity is regulated by the GTPase activity of the ROC domain (Probable). GTP-bound LLRK2 kinase activity is stimulated by RAB29 (Probable). Inhibited by small molecule inhibitors MLi-2 and LRRK2-IN-1 (PubMed:26824392, PubMed:28720718). Homodimer (By similarity). Interacts with PRKN, PRDX3 and TPCN2 (By similarity). Interacts with VPS35 and RAB29 (PubMed:23395371). Interacts (via ROC domain) with SEC16A (PubMed:25201882). Interacts with APP; interaction promotes phosphorylation of 'Thr-743' of APP (PubMed:28720718). Interacts with MAPT (By similarity). Interacts with RAB8A, RAB10, and RAB12 (By similarity). Interacts with YWHAG; this interaction is dependent on phosphorylation of Ser-910 and either Ser-935 or Ser-1444 (By similarity). Interacts with SFN; this interaction is dependent on phosphorylation of Ser-910 and/or Ser-935 (By similarity). Q5S006; Q9EPJ9: Arfgap1; NbExp=3; IntAct=EBI-2693710, EBI-6288020; Q5S006; O55143: Atp2a2; NbExp=9; IntAct=EBI-2693710, EBI-770763; Q5S006; Q8K1M6: Dnm1l; NbExp=5; IntAct=EBI-2693710, EBI-2365792; Q5S006; Q5S006: Lrrk2; NbExp=6; IntAct=EBI-2693710, EBI-2693710; Q5S006; P46460: Nsf; NbExp=3; IntAct=EBI-2693710, EBI-398006; Q5S006; P31324: Prkar2b; NbExp=3; IntAct=EBI-2693710, EBI-455340; Q5S006; Q9CQV8: Ywhab; NbExp=6; IntAct=EBI-2693710, EBI-771608; Q5S006; P62259: Ywhae; NbExp=4; IntAct=EBI-2693710, EBI-356480; Q5S006; P61982: Ywhag; NbExp=10; IntAct=EBI-2693710, EBI-359843; Q5S006; P68510: Ywhah; NbExp=7; IntAct=EBI-2693710, EBI-444641; Q5S006; P68254: Ywhaq; NbExp=4; IntAct=EBI-2693710, EBI-400675; Q5S006; P63101: Ywhaz; NbExp=5; IntAct=EBI-2693710, EBI-354751; Q5S006; P26038: MSN; Xeno; NbExp=2; IntAct=EBI-2693710, EBI-528768; Cytoplasmic vesicle Perikaryon Cell projection, axon Cell projection, dendrite Golgi apparatus membrane ; Peripheral membrane protein doplasmic reticulum membrane ; Peripheral membrane protein toplasmic vesicle, secretory vesicle, synaptic vesicle membrane Endosome Lysosome Mitochondrion outer membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton Note=Colocalized with RAB29 along tubular structures emerging from Golgi apparatus (By similarity). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:25201882). Expressed in the brain (at protein level) (PubMed:28720718). Detected throughout the adult brain. Expressed in deep cerebral cortex layers, superficial cingulate cortex layers, the piriform cortex, hippocampal formation, caudate putamen, substantia nigra, the basolateral and basomedial anterior amygdala nuclei, reticular thalamic nucleus and also in the cerebellar granular cell layer. Highly expressed in the striatum, cortex and olfactory tubercle. Little or no expression in the substantia nigra, where dopaminergic neurons preferentially degenerate in Parkinson disease. Expression is particularly high in brain dopaminoceptive areas. High and strikingly specific expression in striatum and parts of cortex and no signals in dopamine neurons. The seven-bladed WD repeat region is critical for synaptic vesicle trafficking and mediates interaction with multiple vesicle- associated presynaptic proteins (By similarity). It also mediates homodimerization and regulates kinase activity (By similarity). The Roc domain mediates homodimerization and regulates kinase activity. Autophosphorylated (PubMed:28720718, PubMed:29212815). Phosphorylation of Ser-910 and Ser-935 or Ser-1444 facilitates interaction with YWHAG (By similarity). Phosphorylation of Ser-910 and/or Ser-935 facilitates interaction with SFN (By similarity). Ubiquitinated by TRIM1; undergoes 'Lys-48'-linked polyubiquitination leading to proteasomal degradation. Contrary to LRRK1 knockout mice, LRRK2 knockout animals do not show obvious bone phenotypes. Osteoclast precursors differentiate into functional multinucleated cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. SNARE binding MAPK cascade nucleotide binding activation of MAPKK activity activation of MAPK activity magnesium ion binding negative regulation of protein phosphorylation positive regulation of protein phosphorylation actin binding GTPase activity protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity GTPase activator activity protein binding ATP binding GTP binding nucleus cytoplasm mitochondrion mitochondrial outer membrane mitochondrial inner membrane mitochondrial matrix lysosome endosome endoplasmic reticulum Golgi apparatus Golgi-associated vesicle trans-Golgi network cytosol plasma membrane microvillus protein phosphorylation protein import into nucleus endocytosis autophagy response to oxidative stress mitochondrion organization endoplasmic reticulum organization Golgi organization lysosome organization spermatogenesis neuromuscular junction development synaptic vesicle determination of adult lifespan cellular response to starvation regulation of gene expression regulation of autophagy positive regulation of autophagy regulation of protein kinase A signaling negative regulation of protein processing negative regulation of neuron projection development regulation of neuron maturation tubulin binding membrane inclusion body negative regulation of macroautophagy kinase activity phosphorylation transferase activity Rho GTPase binding syntaxin-1 binding peptidyl-serine phosphorylation peptidyl-threonine phosphorylation calcium-mediated signaling striatum development olfactory bulb development tangential migration from the subventricular zone to the olfactory bulb cell junction cell differentiation receptor signaling complex scaffold activity clathrin binding axon dendrite growth cone synaptic vesicle membrane positive regulation of protein ubiquitination cytoplasmic vesicle regulation of protein stability mitochondrial membrane negative regulation of protein binding positive regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process cytoplasmic side of mitochondrial outer membrane dendrite cytoplasm GTP-dependent protein kinase activity negative regulation of GTPase activity cellular response to oxidative stress cellular protein localization intracellular signal transduction regulation of kidney size exploration behavior locomotory exploration behavior regulation of lysosomal lumen pH synaptic vesicle recycling peroxidase inhibitor activity regulation of locomotion regulation of membrane potential identical protein binding protein homodimerization activity cell projection neuron projection neuronal cell body positive regulation of programmed cell death terminal bouton perikaryon intracellular membrane-bounded organelle positive regulation of GTPase activity ion channel binding amphisome autolysosome macromolecular complex binding membrane raft synapse GTP metabolic process protein autophosphorylation intracellular distribution of mitochondria neuron projection morphogenesis protein kinase A binding mitochondrion localization positive regulation of nitric-oxide synthase biosynthetic process regulation of mitochondrial depolarization regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential regulation of dopamine receptor signaling pathway positive regulation of dopamine receptor signaling pathway regulation of ER to Golgi vesicle-mediated transport regulation of canonical Wnt signaling pathway regulation of dendritic spine morphogenesis endoplasmic reticulum exit site protein localization to endoplasmic reticulum exit site neuron death cellular response to manganese ion cellular response to organic cyclic compound reactive oxygen species metabolic process positive regulation of canonical Wnt signaling pathway negative regulation of excitatory postsynaptic potential multivesicular body, internal vesicle postsynapse glutamatergic synapse caveola neck presynaptic cytosol regulation of synaptic vesicle endocytosis positive regulation of synaptic vesicle endocytosis regulation of neuron death negative regulation of neuron death positive regulation of histone deacetylase activity negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of protein autoubiquitination regulation of neuroblast proliferation regulation of synaptic vesicle transport negative regulation of autophagosome assembly negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation negative regulation of hydrogen peroxide-induced cell death negative regulation of protein targeting to mitochondrion cellular response to dopamine positive regulation of microglial cell activation positive regulation of tumor necrosis factor secretion beta-catenin destruction complex binding Wnt signalosome assembly regulation of retrograde transport, endosome to Golgi regulation of CAMKK-AMPK signaling cascade ribonucleoprotein complex Wnt signalosome regulation of branching morphogenesis of a nerve regulation of synaptic vesicle exocytosis uc007xhz.1 uc007xhz.2 uc007xhz.3 
ENSMUST00000060650.7 Frmd7 ENSMUST00000060650.7 FERM domain containing 7 (from RefSeq NM_001190332.2) A2AD83 ENSMUST00000060650.1 ENSMUST00000060650.2 ENSMUST00000060650.3 ENSMUST00000060650.4 ENSMUST00000060650.5 ENSMUST00000060650.6 FRMD7_MOUSE Frmd7 NM_001190332 Q8CCP8 uc012hgz.1 uc012hgz.2 uc012hgz.3 Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability. Cell projection, neuron projection Cell projection, growth cone Note=In undifferentiated neurons, located in the actin-rich regions of the cell body. In differentiated neurons, located in the actin-rich regions of the cell body and primary neurite processes but is almost absent from secondary extensions arising from the primary neurite. Also found at the actin-rich distal end of growth cones. In the developing cerebral cortex, strong expression is observed in the ventricular and intermediate zones at 13 and 17 dpc. At 17 dpc and P0, expression appears to be restricted to the cortical plate. In neonates, highly expressed in cortex, hippocampus, cerebellum, olfactory bulb and eye with little or no expression in liver, kidney, skeletal muscle or heart muscle (at protein level). Up-regulated during retinoic acid-induced differentiation of neuroblastoma cells. Sequence=AAI47258.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI47259.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC27826.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function protein binding cytoskeleton nervous system development positive regulation of lamellipodium assembly regulation of neuron projection development growth cone negative regulation of protein binding cell projection neuron projection neuronal cell body positive regulation of small GTPase mediated signal transduction negative regulation of stress fiber assembly Rac guanyl-nucleotide exchange factor activity uc012hgz.1 uc012hgz.2 uc012hgz.3 
ENSMUST00000060655.15 Nod1 ENSMUST00000060655.15 nucleotide-binding oligomerization domain containing 1, transcript variant 1 (from RefSeq NM_172729.3) ENSMUST00000060655.1 ENSMUST00000060655.10 ENSMUST00000060655.11 ENSMUST00000060655.12 ENSMUST00000060655.13 ENSMUST00000060655.14 ENSMUST00000060655.2 ENSMUST00000060655.3 ENSMUST00000060655.4 ENSMUST00000060655.5 ENSMUST00000060655.6 ENSMUST00000060655.7 ENSMUST00000060655.8 ENSMUST00000060655.9 NM_172729 NOD1_MOUSE Nod1 Q8BHB0 Q8BUT6 uc009cag.1 uc009cag.2 uc009cag.3 uc009cag.4 Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and thus participates in both innate and adaptive immune responses (PubMed:12796777, PubMed:21715553). Specifically recognizes and binds gamma-D-glutamyl- meso-diaminopimelic acid (iE-DAP), a dipeptide present in peptidoglycan of Gram-negative bacteria (PubMed:12796777, PubMed:16211083). Preferentially binds iE-DAP in tetrapeptide-containing muropeptides (MurNAc-TetraDAP or TetraDAP) (PubMed:16211083). Ligand binding triggers oligomerization that facilitates the binding and subsequent activation of the proximal adapter receptor-interacting RIPK2 (By similarity). Following recruitment, RIPK2 undergoes 'Met-1'- (linear) and 'Lys-63'-linked polyubiquitination by E3 ubiquitin-protein ligases XIAP, BIRC2, BIRC3 and the LUBAC complex, becoming a scaffolding protein for downstream effectors, triggering activation of the NF- kappa-B and MAP kinases signaling (By similarity). This in turn leads to the transcriptional activation of hundreds of genes involved in immune response (By similarity). Also acts as a regulator of antiviral response elicited by dsRNA and the expression of RLR pathway members by targeting IFIH1 and TRAF3 to modulate the formation of IFIH1-MAVS and TRAF3-MAVS complexes leading to increased transcription of type I IFNs (By similarity). Also acts as a regulator of autophagy via its interaction with ATG16L1, possibly by recruiting ATG16L1 at the site of bacterial entry (PubMed:19898471). Besides recognizing pathogens, also involved in the endoplasmic reticulum stress response: acts by sensing and binding to the cytosolic metabolite sphingosine-1-phosphate generated in response to endoplasmic reticulum stress, initiating an inflammation process that leads to activation of the NF-kappa-B and MAP kinases signaling (PubMed:27007849). In addition, plays a role in insulin trafficking in beta cells in a cell-autonomous manner (PubMed:21715553, PubMed:31201384). Mechanistically, upon recognizing cognate ligands, NOD1 and RIPK2 localize to insulin vesicles where they recruit RAB1A to direct insulin trafficking through the cytoplasm (PubMed:31201384). Homooligomer: homooligomerizes following ligand-binding, promoting RIPK2 recruitment (By similarity). Interacts (via CARD domain) with RIPK2 (via CARD domain) (By similarity). Following RIPK2 recruitment, RIPK2 homooligomerizes via its CARD domain and forms long filaments named RIPosomes (By similarity). Interacts (via CARD domain) with ubiquitin; inhibiting interaction with RIPK2 (By similarity). Interacts with ARHGEF2 (By similarity). Interacts with NLRP10 and recruits it to the cell membrane following invasive bacterial infection (By similarity). Interacts with IFIH1; this interaction promotes transcription of antiviral genes and inhibition of viral replication (By similarity). Interacts with Irgm1; promoting NOD1 degradation (By similarity). Interacts with ATG16L1 (PubMed:19898471). Cell membrane ; Lipid-anchor Apical cell membrane Basolateral cell membrane Cytoplasm Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells. Although ubiquitously expressed, NOD1 levels are more abundant in immune cells, the gastrointestinal tract, and adipose tissue. Ubiquitinated. 'Lys-48'-linked polyubiquitination by RNF34 promotes proteasomal degradation and thereby negatively regulates NOD1 for instance in NF-kappa-B activation. Palmitoylated. Palmitoylation is required for proper recruitment to the bacterial entry site and hence for proper signaling upon cognate peptidoglycan detection. Degraded via selective autophagy following interaction with Irgm1. Irgm1 promotes NOD1-RIPK2 RIPosome recruitment to autophagosome membranes, promoting their SQSTM1/p62-dependent autophagic degradation. No visible phenotype in absence of infection (PubMed:12796777). Mice however show impaired cytokine secretion in response to bacterial infection: macrophages do not secrete cytokines in response to synthetic gamma-D-glutamyl-meso-diaminopimelic acid (iE- DAP) and do not prime the lipopolysaccharide response (PubMed:12796777). Deletion mutant mice show a normal glucose tolerance but the level of circulating insulin after glucose infusion was significantly lower than in wild-type mice (PubMed:31201384). Mice lacking Nod1 and Nod2 are protected from high-fat diet-induced inflammation, lipid accumulation, and peripheral insulin intolerance (PubMed:21715553). Belongs to the NOD1-NOD2 family. Human and mouse NOD1 bind gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) in a different context (PubMed:16211083). do not detect the same muropeptide from bacterial peptidoglycan: while human NOD1 detects a tripeptide-containing muropeptide (MurNAc-TriDAP or TriDAP), mouse Nod1 needs a tetrapeptide structure for efficient sensing (MurNAc-tetraDAP or TetraDAP) (PubMed:16211083). nucleotide binding immune system process positive regulation of dendritic cell antigen processing and presentation protein binding ATP binding cytoplasm plasma membrane apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process defense response positive regulation of cell death membrane detection of bacterium basolateral plasma membrane apical plasma membrane positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade intracellular signal transduction interleukin-8 biosynthetic process defense response to bacterium identical protein binding protein homodimerization activity regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process macromolecular complex binding innate immune response positive regulation of JNK cascade CARD domain binding defense response to Gram-positive bacterium positive regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade cellular response to muramyl dipeptide positive regulation of NIK/NF-kappaB signaling positive regulation of xenophagy uc009cag.1 uc009cag.2 uc009cag.3 uc009cag.4 
ENSMUST00000060673.8 Liph ENSMUST00000060673.8 lipase, member H, transcript variant 3 (from RefSeq NM_001289581.1) ENSMUST00000060673.1 ENSMUST00000060673.2 ENSMUST00000060673.3 ENSMUST00000060673.4 ENSMUST00000060673.5 ENSMUST00000060673.6 ENSMUST00000060673.7 LIPH_MOUSE NM_001289581 Q3TRT3 Q3TTZ0 Q3UWA2 Q8BXB5 Q8CI45 Q8CIV3 uc007yru.1 uc007yru.2 uc007yru.3 uc007yru.4 Hydrolyzes specifically phosphatidic acid (PA) to produce 2- acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid (By similarity). Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG) (By similarity). Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate; Xref=Rhea:RHEA:40943, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64839, ChEBI:CHEBI:77593; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40944; Evidence=; Interacts with TTMP/C3orf52. Secreted Cell membrane ; Peripheral membrane protein. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CIV3-1; Sequence=Displayed; Name=2; IsoId=Q8CIV3-2; Sequence=VSP_022506; Name=3; IsoId=Q8CIV3-3; Sequence=VSP_022505; Expressed in placenta and colon. Weakly expressed in small intestine. Belongs to the AB hydrolase superfamily. Lipase family. phospholipase activity extracellular region extracellular space plasma membrane lipid metabolic process heparin binding membrane lipid catabolic process lipase activity hydrolase activity carboxylic ester hydrolase activity uc007yru.1 uc007yru.2 uc007yru.3 uc007yru.4 
ENSMUST00000060700.4 Ankrd34c ENSMUST00000060700.4 Belongs to the ANKRD34 family. (from UniProt Q8BLB8) AK045652 AN34C_MOUSE ENSMUST00000060700.1 ENSMUST00000060700.2 ENSMUST00000060700.3 Q8BLB8 uc012gyd.1 uc012gyd.2 uc012gyd.3 Belongs to the ANKRD34 family. molecular_function cellular_component biological_process uc012gyd.1 uc012gyd.2 uc012gyd.3 
ENSMUST00000060703.6 Ccer1 ENSMUST00000060703.6 coiled-coil glutamate-rich protein 1 (from RefSeq NM_025724.2) CCER1_MOUSE ENSMUST00000060703.1 ENSMUST00000060703.2 ENSMUST00000060703.3 ENSMUST00000060703.4 ENSMUST00000060703.5 NM_025724 Q9CQL2 uc007gxd.1 uc007gxd.2 uc007gxd.3 molecular_function cellular_component biological_process uc007gxd.1 uc007gxd.2 uc007gxd.3 
ENSMUST00000060710.9 Cdc25c ENSMUST00000060710.9 cell division cycle 25C (from RefSeq NM_009860.3) Cdc25c ENSMUST00000060710.1 ENSMUST00000060710.2 ENSMUST00000060710.3 ENSMUST00000060710.4 ENSMUST00000060710.5 ENSMUST00000060710.6 ENSMUST00000060710.7 ENSMUST00000060710.8 NM_009860 Q3UR74 Q3UR74_MOUSE uc008elf.1 uc008elf.2 uc008elf.3 uc008elf.4 uc008elf.5 uc008elf.6 This gene encodes a dual specificity phosphatase that dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis. [provided by RefSeq, Dec 2014]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK141737.1, AK168287.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Belongs to the MPI phosphatase family. G2/M transition of mitotic cell cycle protein tyrosine phosphatase activity nucleus protein dephosphorylation spermatogenesis nuclear speck protein kinase binding peptidyl-tyrosine dephosphorylation perinuclear region of cytoplasm WW domain binding cell division positive regulation of cell cycle G2/M phase transition uc008elf.1 uc008elf.2 uc008elf.3 uc008elf.4 uc008elf.5 uc008elf.6 
ENSMUST00000060714.10 Ubqln2 ENSMUST00000060714.10 ubiquilin 2 (from RefSeq NM_018798.2) B1AY62 ENSMUST00000060714.1 ENSMUST00000060714.2 ENSMUST00000060714.3 ENSMUST00000060714.4 ENSMUST00000060714.5 ENSMUST00000060714.6 ENSMUST00000060714.7 ENSMUST00000060714.8 ENSMUST00000060714.9 NM_018798 Plic2 Q7TSJ8 Q8VDH9 Q9QZM0 UBQL2_MOUSE uc009uqw.1 uc009uqw.2 uc009uqw.3 uc009uqw.4 Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and the endoplasmic reticulum- associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (By similarity). Links CD47 to vimentin- containing intermediate filaments of the cytoskeleton (PubMed:10549293). Homodimer. Forms heterodimer with UBQLN1. Binds UBE3A and BTRC. Interacts with the 19S proteasome subunit. Interacts with C9orf72 (By similarity). Binds CD47 (PubMed:10549293). Interacts with HNRNPA1 and HNRNPU. Found in a complex with UBQLN1 and MAP1LC3A/B/C. Interacts with EPS15, EPN1 and EPN2. Interacts with HERPUD1. Interacts with RAD23A. Interacts with TARDBP. Interacts (via C-terminus) with FAF2 (via N-terminus). Interacts with UBQLN4 (By similarity). Cytoplasm Nucleus Membrane Cytoplasmic vesicle, autophagosome Note=Colocalizes with a subset of proteasomes, namely those that are cytoskeleton associated or free in the cytosol. Associated with fibers in mitotic cells. Highly expressed in smooth muscle. Expression in other tissues is very low. The ubiquitin-like domain is essential for its inhibitory effect on GPCR endocytosis. Mediates its association with the subunits of the proteasome. The UBA domain is essential for its association with microtubule-associated protein 1 light chain 3 (MAP1LC3). Mediates its association with ubiquitinated substrates. Dimerization is dependent upon the central region of the protein containing the STI1 domains and is independent of its ubiquitin-like and UBA domains. Degraded during macroautophagy. autophagosome assembly protein binding nucleus cytoplasm autophagosome cytosol plasma membrane ubiquitin-dependent protein catabolic process autophagy membrane regulation of macroautophagy ER-associated ubiquitin-dependent protein catabolic process cytoplasmic vesicle polyubiquitin binding negative regulation of clathrin-dependent endocytosis positive regulation of ER-associated ubiquitin-dependent protein catabolic process negative regulation of G-protein coupled receptor internalization regulation of autophagosome assembly uc009uqw.1 uc009uqw.2 uc009uqw.3 uc009uqw.4 
ENSMUST00000060716.6 Samd3 ENSMUST00000060716.6 sterile alpha motif domain containing 3, transcript variant 5 (from RefSeq NM_001408267.1) E9Q3G4 E9Q3G4_MOUSE ENSMUST00000060716.1 ENSMUST00000060716.2 ENSMUST00000060716.3 ENSMUST00000060716.4 ENSMUST00000060716.5 NM_001408267 Samd3 uc011xbx.1 uc011xbx.2 uc011xbx.1 uc011xbx.2 
ENSMUST00000060719.12 Tlr7 ENSMUST00000060719.12 toll-like receptor 7, transcript variant 3 (from RefSeq NM_133211.4) ENSMUST00000060719.1 ENSMUST00000060719.10 ENSMUST00000060719.11 ENSMUST00000060719.2 ENSMUST00000060719.3 ENSMUST00000060719.4 ENSMUST00000060719.5 ENSMUST00000060719.6 ENSMUST00000060719.7 ENSMUST00000060719.8 ENSMUST00000060719.9 NM_133211 Q548J0 Q548J0_MOUSE Tlr7 uc009uxa.1 uc009uxa.2 uc009uxa.3 uc009uxa.4 Cytoplasmic vesicle, phagosome Endoplasmic reticulum membrane ; Single-pass type I membrane protein Lysosome Membrane ; Single-pass type I membrane protein Belongs to the Toll-like receptor family. microglial cell activation toll-like receptor signaling pathway immune system process MyD88-dependent toll-like receptor signaling pathway double-stranded RNA binding single-stranded RNA binding transmembrane signaling receptor activity cytoplasm plasma membrane immune response signal transduction I-kappaB phosphorylation drug binding membrane integral component of membrane positive regulation of chemokine production positive regulation of interleukin-8 production toll-like receptor 7 signaling pathway receptor complex positive regulation of interferon-gamma biosynthetic process innate immune response positive regulation of interferon-alpha biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of interleukin-8 biosynthetic process defense response to virus cellular response to mechanical stimulus positive regulation of NIK/NF-kappaB signaling uc009uxa.1 uc009uxa.2 uc009uxa.3 uc009uxa.4 
ENSMUST00000060722.8 Cxxc5 ENSMUST00000060722.8 CXXC finger 5, transcript variant 1 (from RefSeq NM_133687.3) CXXC5_MOUSE ENSMUST00000060722.1 ENSMUST00000060722.2 ENSMUST00000060722.3 ENSMUST00000060722.4 ENSMUST00000060722.5 ENSMUST00000060722.6 ENSMUST00000060722.7 NM_133687 Q3V0R4 Q8CES6 Q8CF49 Q91WA4 uc008emx.1 uc008emx.2 uc008emx.3 uc008emx.4 May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity). Binds preferentially to DNA containing cytidine- phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity). Interacts with DVL1 (By similarity). Interacts with RBPJ (By similarity). Nucleus Cytoplasm Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane. Expressed in dorsal pallium and in and around the developing choroid plexus at 10.5 and 12.5 dpc. The CXXC zinc finger mediates binding to CpG-DNA. Sequence=BAC25113.1; Type=Frameshift; Evidence=; Sequence=BAC25458.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter DNA binding nucleus nucleoplasm cytoplasm cytosol transcription factor binding zinc ion binding sequence-specific DNA binding metal ion binding uc008emx.1 uc008emx.2 uc008emx.3 uc008emx.4 
ENSMUST00000060738.9 S100a1 ENSMUST00000060738.9 S100 calcium binding protein A1 (from RefSeq NM_011309.3) ENSMUST00000060738.1 ENSMUST00000060738.2 ENSMUST00000060738.3 ENSMUST00000060738.4 ENSMUST00000060738.5 ENSMUST00000060738.6 ENSMUST00000060738.7 ENSMUST00000060738.8 NM_011309 Q91V77 Q91V77_MOUSE S100a1 uc008qct.1 uc008qct.2 uc008qct.3 Cytoplasm Mitochondrion Sarcoplasmic reticulum Belongs to the S-100 family. negative regulation of transcription from RNA polymerase II promoter calcium ion binding nucleus cytoplasm regulation of heart contraction sarcoplasmic reticulum Z disc M band A band I band identical protein binding protein homodimerization activity neuron projection S100 protein binding metal ion binding calcium-dependent protein binding positive regulation of nitric-oxide synthase activity ATPase binding positive regulation of voltage-gated calcium channel activity positive regulation of sprouting angiogenesis uc008qct.1 uc008qct.2 uc008qct.3 
ENSMUST00000060747.8 Bhlha15 ENSMUST00000060747.8 basic helix-loop-helix family, member a15 (from RefSeq NM_010800.4) BHA15_MOUSE Bhlhb8 ENSMUST00000060747.1 ENSMUST00000060747.2 ENSMUST00000060747.3 ENSMUST00000060747.4 ENSMUST00000060747.5 ENSMUST00000060747.6 ENSMUST00000060747.7 Mist1 NM_010800 Q9QYC3 Q9QYE4 uc009alh.1 uc009alh.2 Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated (PubMed:17612490). Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3'. Forms homodimers or heterodimers with TCF3 gene products E12 and E47. These dimers bind to the E-box site, however, heterodimer with MYOD1 does not bind target DNA. Nucleus Expressed in pancreatic tissue only in acinar cells. There is a complete absence of expression in intra- or interlobular pancreatic ducts and in all islet cells. First observed at 10.5 dpc in the primitive gut and in the developing lung bud. Expression in the gut persists through 16.5 dpc and remains restricted primarily to the epithelial lining of the esophagus, stomach and intestine. Expression in the lung is detected in the bronchial epithelium at 14.5 dpc and at 15.5 dpc. Expressed specifically in acinar cells during pancreatic development. Detected in skeletal muscle tissues beginning at 12.5 dpc, persisting throughout all embryonic stages examined although, in older embryos expression becomes severely reduced. Up-regulated by XBP1. Induced by chemical activators of the unfolded protein response (UPR) such as tunicamycin and thapsigargin, and also by glucose starvation (PubMed:17612490). Lacks a classic transcription activation domain and instead possesses an N-terminal region capable of inhibiting heterologous activators. Mice display incorrect granule organization in pancreatic acinar cells and other serous exocrine cells such as parotid acini and gastric chief cells. They also display mislocalization of mitochondria and Golgi apparatus and reduced Ca(2+) uptake by mitochondria. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus regulation of transcription, DNA-templated mitochondrial calcium ion transport Golgi organization G-protein coupled receptor signaling pathway cell-cell signaling negative regulation of myotube differentiation calcium-mediated signaling endoplasmic reticulum unfolded protein response cellular response to glucose starvation glucose homeostasis protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter protein dimerization activity intracellular distribution of mitochondria cell maturation uc009alh.1 uc009alh.2 
ENSMUST00000060761.8 Phxr2 ENSMUST00000060761.8 Phxr2 (from geneSymbol) ENSMUST00000060761.1 ENSMUST00000060761.2 ENSMUST00000060761.3 ENSMUST00000060761.4 ENSMUST00000060761.5 ENSMUST00000060761.6 ENSMUST00000060761.7 X12808 uc287uky.1 uc287uky.2 uc287uky.3 uc287uky.1 uc287uky.2 uc287uky.3 
ENSMUST00000060762.6 Zfp397 ENSMUST00000060762.6 zinc finger protein 397 (from RefSeq NM_027007.2) ENSMUST00000060762.1 ENSMUST00000060762.2 ENSMUST00000060762.3 ENSMUST00000060762.4 ENSMUST00000060762.5 NM_027007 Q7TNK4 Q7TNK4_MOUSE Zfp397 uc008egh.1 uc008egh.2 uc008egh.3 uc008egh.4 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus nucleolus cytoplasm cytosol plasma membrane regulation of transcription, DNA-templated microtubule cytoskeleton protein homodimerization activity negative regulation of transcription, DNA-templated metal ion binding protein heterodimerization activity uc008egh.1 uc008egh.2 uc008egh.3 uc008egh.4 
ENSMUST00000060783.7 Zfp768 ENSMUST00000060783.7 zinc finger protein 768 (from RefSeq NM_146202.1) ENSMUST00000060783.1 ENSMUST00000060783.2 ENSMUST00000060783.3 ENSMUST00000060783.4 ENSMUST00000060783.5 ENSMUST00000060783.6 NM_146202 Q8R0T2 ZN768_MOUSE Znf768 uc009jvc.1 uc009jvc.2 uc009jvc.3 Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (By similarity). Required for cell homeostasis (By similarity). May be involved in transcriptional regulation (Probable). Interacts (via zinc-finger domains) with TP53 (via N- terminus); interaction might be facilitated by TP53 oligomerization state (By similarity). Interacts with ELP3 (By similarity). Nucleus Chromosome Note=Localizes to euchromatin. May be phosphorylated at residue 'Ser-5' of the tandem heptapeptide repeats in the N-terminus (By similarity). Phosphorylation might be increased upon RAS pathway activation and negatively regulate protein stability (By similarity). Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus DNA-directed RNA polymerase II, core complex transcription from RNA polymerase II promoter biological_process metal ion binding uc009jvc.1 uc009jvc.2 uc009jvc.3 
ENSMUST00000060792.6 Cavin1 ENSMUST00000060792.6 caveolae associated 1, transcript variant 1 (from RefSeq NM_008986.2) CAVN1_MOUSE ENSMUST00000060792.1 ENSMUST00000060792.2 ENSMUST00000060792.3 ENSMUST00000060792.4 ENSMUST00000060792.5 NM_008986 O54724 Ptrf Q2TAW6 uc007lmr.1 uc007lmr.2 uc007lmr.3 uc007lmr.4 Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18191225, PubMed:18840361, PubMed:18056712, PubMed:30188967). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1) (PubMed:19546242). Essential for normal oligomerization of CAV1 (PubMed:23652019). Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop (PubMed:27528195). Dissociates transcription complexes paused by DNA- bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (PubMed:9582279, PubMed:11139612). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (PubMed:30188967). Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4 (PubMed:19546242). Homotrimer (PubMed:25588833). Interacts with LIPE in the adipocyte cytoplasm (By similarity). Interacts with RNA polymerase I (PubMed:9582279). Interacts with TTF1 (PubMed:9582279, PubMed:27528195). Binds the 3' end of pre-rRNA (PubMed:9582279). Interacts with transcription factor ZNF148 (PubMed:10727401). Interacts with CAV1, CAVIN2 and CAVIN3 (PubMed:25588833, PubMed:19546242). Interacts with CAVIN4 (PubMed:19546242). Membrane, caveola ll membrane Microsome Endoplasmic reticulum Cytoplasm, cytosol Mitochondrion Nucleus Note=Translocates to the cytoplasm from caveolae upon insulin stimulation (By similarity). Colocalizes with CAV1 in lipid rafts in adipocytes (PubMed:18056712). Localizes in the caveolae in a caveolin- dependent manner (PubMed:19546242). Expressed in the heart, stomach, adipose tissue and lung (at protein level). Expressed in testis, kidney, muscle, liver, spleen and brain. The leucine-zipper domain 1 is essential for its localization in the caveolae. Phosphorylated. Present in active and inactive forms. Changes in phosphorylation pattern may alter activity. Phosphorylation at Tyr-158 is essential for its function in the regulation of the ribosomal transcriptional activity. Monoubiquitinated. Mice show a metabolic phenotype of significantly reduced adipose tissue mass, higher circulating triglyceride levels, glucose intolerance, and hyperinsulinemia, consistent with a lipodystrophy. Cells from various tissues, including lung epithelium, intestinal smooth muscle, skeletal muscle, and endothelial cells showed no detectable caveolae cells. Belongs to the CAVIN family. RNA binding protein binding nucleus cytoplasm mitochondrion endoplasmic reticulum cytosol plasma membrane caveola DNA-templated transcription, termination transcription initiation from RNA polymerase I promoter termination of RNA polymerase I transcription rRNA transcription protein secretion membrane rRNA binding macromolecular complex rRNA primary transcript binding identical protein binding intracellular membrane-bounded organelle membrane raft positive regulation of cell motility uc007lmr.1 uc007lmr.2 uc007lmr.3 uc007lmr.4 
ENSMUST00000060798.6 Unc119b ENSMUST00000060798.6 unc-119 lipid binding chaperone B (from RefSeq NM_175352.4) ENSMUST00000060798.1 ENSMUST00000060798.2 ENSMUST00000060798.3 ENSMUST00000060798.4 ENSMUST00000060798.5 NM_175352 Q14BY8 Q8BRC4 Q8C4B4 Q922B4 U119B_MOUSE uc008zdc.1 uc008zdc.2 uc008zdc.3 Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells (By similarity). Found in a complex with ARL3, RP2 and UNC119B; RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119B. Interacts with NPHP3 (when myristoylated). Interacts with CYS1 (when myristoylated). Interacts with MACIR; interaction only takes place when UNC119B is not liganded with myristoylated proteins (By similarity). Cell projection, cilium Note=Enriched at the transition zone and extended into the proximal end of the cilium. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C4B4-1; Sequence=Displayed; Name=2; IsoId=Q8C4B4-2; Sequence=VSP_033985; Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (By similarity). Belongs to the PDE6D/unc-119 family. cilium nervous system development lipid binding protein transport cell projection organization ciliary transition zone lipoprotein transport cell projection cilium assembly uc008zdc.1 uc008zdc.2 uc008zdc.3 
ENSMUST00000060805.7 Fam120a ENSMUST00000060805.7 family with sequence similarity 120, member A (from RefSeq NM_001033268.3) A0PJK6 B3DFJ0 ENSMUST00000060805.1 ENSMUST00000060805.2 ENSMUST00000060805.3 ENSMUST00000060805.4 ENSMUST00000060805.5 ENSMUST00000060805.6 F120A_MOUSE FAM120A Kiaa0183 NM_001033268 Ossa Q6A0A9 Q91Z16 uc007qio.1 uc007qio.2 uc007qio.3 uc007qio.4 Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases. May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase. Binds IGF2 RNA and promotes the production of IGF2 protein. Interacts with PURA (PubMed:18413649). Interacts with SRC family protein kinases YES1, SRC and FYN. Upon tyrosine phosphorylation, interacts with PIK3R1. Interacts with IGF2BP1/IMP-1 in an RNA-dependent manner (By similarity). Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Translocates from the cytosol to plasma membrane after UV irradiation. In the brain, predominantly expressed in the hippocampus, caudate putamen, cerebral cortex and cerebellum. Expression is restricted to neurons (at protein level). Expressed in the developing brain at 12 dpc. Expression increases postnatally and is maintained at an adult level beyond 4 weeks after birth (at protein level). Arg-980 is dimethylated, probably to asymmetric dimethylarginine. Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure. Belongs to the constitutive coactivator of PPAR-gamma family. Sequence=BAD32187.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA binding nucleus cytoplasm cytosol plasma membrane membrane uc007qio.1 uc007qio.2 uc007qio.3 uc007qio.4 
ENSMUST00000060807.12 Fam83h ENSMUST00000060807.12 family with sequence similarity 83, member H, transcript variant 2 (from RefSeq NM_134087.2) ENSMUST00000060807.1 ENSMUST00000060807.10 ENSMUST00000060807.11 ENSMUST00000060807.2 ENSMUST00000060807.3 ENSMUST00000060807.4 ENSMUST00000060807.5 ENSMUST00000060807.6 ENSMUST00000060807.7 ENSMUST00000060807.8 ENSMUST00000060807.9 FA83H_MOUSE Fam83h NM_134087 Q148V8 Q8BZF6 Q8CI79 Q8R5C2 Q8R5D0 uc007wid.1 uc007wid.2 uc007wid.3 uc007wid.4 May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration. Interacts with CSNK1A1; recruits CSNK1A1 to keratin filaments. Interacts with KRT18 and probably other keratins. Cytoplasm, cytoskeleton Note=Colocalizes with keratin filaments. Expressed in tooth follicle, eye, liver and kidney. Belongs to the FAM83 family. Sequence=AAH36149.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cytoplasm cytoskeleton protein kinase binding positive regulation of cell migration biomineral tissue development protein localization to cytoskeleton keratin filament intermediate filament cytoskeleton organization keratin filament binding uc007wid.1 uc007wid.2 uc007wid.3 uc007wid.4 
ENSMUST00000060820.8 Nkx3-2 ENSMUST00000060820.8 NK3 homeobox 2 (from RefSeq NM_007524.3) A6H6G9 Bapx1 ENSMUST00000060820.1 ENSMUST00000060820.2 ENSMUST00000060820.3 ENSMUST00000060820.4 ENSMUST00000060820.5 ENSMUST00000060820.6 ENSMUST00000060820.7 NKX32_MOUSE NM_007524 Nkx-3.2 Nkx3b P97503 uc008xhc.1 uc008xhc.2 uc008xhc.3 Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus. Nucleus Expressed widely in mesoderm at the gastroduodenal junction (at protein level). Expressed in visceral mesoderm and embryonic skeleton. Expression is restricted to immature proliferative chondrocytes during endochondral ossification. During embryogenesis, expressed in a discrete domain within the mandibular component of the first branchial arch and later in the primordia of middle earassociated bones, the gonium and tympanic ring. Belongs to the NK-3 homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated determination of left/right symmetry cell differentiation pancreas development negative regulation of chondrocyte differentiation middle ear morphogenesis negative regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter animal organ development spleen development animal organ formation skeletal system morphogenesis embryonic skeletal system development digestive system development intestinal epithelial cell development uc008xhc.1 uc008xhc.2 uc008xhc.3 
ENSMUST00000060833.14 Gpa33 ENSMUST00000060833.14 glycoprotein A33 transmembrane, transcript variant 1 (from RefSeq NM_021610.2) A0A0R4J209 A0A0R4J209_MOUSE ENSMUST00000060833.1 ENSMUST00000060833.10 ENSMUST00000060833.11 ENSMUST00000060833.12 ENSMUST00000060833.13 ENSMUST00000060833.2 ENSMUST00000060833.3 ENSMUST00000060833.4 ENSMUST00000060833.5 ENSMUST00000060833.6 ENSMUST00000060833.7 ENSMUST00000060833.8 ENSMUST00000060833.9 Gpa33 NM_021610 uc007dkj.1 uc007dkj.2 uc007dkj.3 integral component of plasma membrane membrane integral component of membrane uc007dkj.1 uc007dkj.2 uc007dkj.3 
ENSMUST00000060834.12 Alkbh6 ENSMUST00000060834.12 alkB homolog 6 (from RefSeq NM_198027.3) ALKB6_MOUSE ENSMUST00000060834.1 ENSMUST00000060834.10 ENSMUST00000060834.11 ENSMUST00000060834.2 ENSMUST00000060834.3 ENSMUST00000060834.4 ENSMUST00000060834.5 ENSMUST00000060834.6 ENSMUST00000060834.7 ENSMUST00000060834.8 ENSMUST00000060834.9 G3X994 NM_198027 Q8K2U2 uc009geb.1 uc009geb.2 uc009geb.3 Probable dioxygenase that requires molecular oxygen, alpha- ketoglutarate and iron. Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. Interacts with VCPKMT. Cytoplasm Nucleus Belongs to the alkB family. Sequence=AAH29805.1; Type=Frameshift; Evidence=; nucleus nucleoplasm cytoplasm focal adhesion biological_process oxidoreductase activity metal ion binding dioxygenase activity oxidation-reduction process oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors uc009geb.1 uc009geb.2 uc009geb.3 
ENSMUST00000060835.12 Tex14 ENSMUST00000060835.12 testis expressed gene 14 intercellular bridge forming factor, transcript variant 2 (from RefSeq NM_031386.2) B2KGL0 ENSMUST00000060835.1 ENSMUST00000060835.10 ENSMUST00000060835.11 ENSMUST00000060835.2 ENSMUST00000060835.3 ENSMUST00000060835.4 ENSMUST00000060835.5 ENSMUST00000060835.6 ENSMUST00000060835.7 ENSMUST00000060835.8 ENSMUST00000060835.9 NM_031386 Q3UT36 Q5NC10 Q5NC11 Q7M6U3 Q8CGK1 Q8CGK2 Q99MV8 TEX14_MOUSE uc007ktr.1 uc007ktr.2 uc007ktr.3 Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro. Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and PDCD6IP/ALIX and TSG101. Q7M6U3; Q8BT07: Cep55; NbExp=11; IntAct=EBI-6674575, EBI-2552328; Cytoplasm. Midbody. Chromosome, centromere, kinetochore. Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7M6U3-1; Sequence=Displayed; Name=2; IsoId=Q7M6U3-2; Sequence=VSP_019870; Detected in testis and spermatogonia. Not detectable in the other tissues tested. Detected at low levels in developing testis at 5 and 10 days after birth. Highly expressed in testis 15 and 20 days after birth. Highly expressed in pachytene, diplotene and meiotically dividing spermatocytes and in early round spermatids. The protein kinase domain is predicted to be catalytically inactive. The GPPX3Y motif mediates interaction with CEP55. Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-431 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex. Male mice are sterile, due to the absence of intercellular bridges. Intercellular bridges do not form during spermatogenesis, and male mice are sterile. In females, embryonic intercellular bridges are also absent, mice have fewer oocytes, but they are fertile. Used as a marker for intercellular bridges. Belongs to the protein kinase superfamily. Ser-370 is present instead of the conserved Asp which is expected to be an active site residue. Sequence=CAI35965.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding chromosome, centromeric region kinetochore condensed chromosome kinetochore protein kinase activity protein binding ATP binding cell chromosome cytoplasm protein phosphorylation cell cycle mitotic spindle assembly checkpoint male meiosis attachment of spindle microtubules to kinetochore protein kinase binding midbody negative regulation of protein binding negative regulation of cytokinesis intercellular bridge organization intercellular bridge cell division mitotic sister chromatid separation cellular response to leukemia inhibitory factor uc007ktr.1 uc007ktr.2 uc007ktr.3 
ENSMUST00000060837.10 Rab11fip5 ENSMUST00000060837.10 RAB11 family interacting protein 5 (class I), transcript variant 2 (from RefSeq NM_177466.4) C4IXU4 D6Ertd32e ENSMUST00000060837.1 ENSMUST00000060837.2 ENSMUST00000060837.3 ENSMUST00000060837.4 ENSMUST00000060837.5 ENSMUST00000060837.6 ENSMUST00000060837.7 ENSMUST00000060837.8 ENSMUST00000060837.9 GAF1 NM_177466 Q8R361 RFIP5_MOUSE Rab11fip5 Rip11 uc009cpo.1 uc009cpo.2 uc009cpo.3 Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. Interacts with RAB11FIP4 (By similarity). Interacts with NAPG (By similarity). Interacts with RO60 (By similarity). Interacts with RAB11A that has been activated by GTP binding (By similarity). Cytoplasm Recycling endosome membrane ; Peripheral membrane protein Early endosome membrane ; Peripheral membrane protein Golgi apparatus membrane ; Peripheral membrane protein Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein Mitochondrion membrane ; Peripheral membrane protein Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg(2+) rather than Ca(2+) (By similarity). Phosphorylated on serine and threonine residues. Phosphorylation at Ser-357 is PKA-dependent. Golgi membrane cytoplasm mitochondrion mitochondrial outer membrane endosome early endosome Golgi apparatus microtubule organizing center protein transport membrane Rab GTPase binding secretory granule transport vesicle membrane cytoplasmic vesicle early endosome membrane mitochondrial membrane insulin secretion involved in cellular response to glucose stimulus gamma-tubulin binding intracellular membrane-bounded organelle regulated exocytosis phagocytic vesicle recycling endosome recycling endosome membrane negative regulation of adiponectin secretion cellular response to interferon-gamma cellular response to acidic pH regulation of protein localization to cell surface uc009cpo.1 uc009cpo.2 uc009cpo.3 
ENSMUST00000060855.7 H1f7 ENSMUST00000060855.7 H1.7 linker histone (from RefSeq NM_027304.2) ENSMUST00000060855.1 ENSMUST00000060855.2 ENSMUST00000060855.3 ENSMUST00000060855.4 ENSMUST00000060855.5 ENSMUST00000060855.6 H1-7 H1FNT_MOUSE H1f7 H1fnt Hanp1 NM_027304 Q5GKZ6 Q5RKV2 Q8CJI4 Q9CVV3 uc007xmd.1 uc007xmd.2 uc007xmd.3 uc007xmd.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. This gene encodes a testis specific protein that is required for spermatogenesis and male fertility. [provided by RefSeq, Oct 2015]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 24781148 ##RefSeq-Attributes-END## Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. Nucleus romosome te=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole. Testis-specific. Specifically expressed in haploid germ cells. First detected in round spermatids at stage 4 and expression strongly increases through stages 5-8. Localization in the nucleus is highly polar and it is concentrated in a cap-like structure at the inner periphery of the nuclear membrane. Polarized expression persists in steps 9-14 elongating spermatids before rapidly disappearing by stage 15. Belongs to the histone H1/H5 family. Sequence=BAB24570.1; Type=Frameshift; Evidence=; nucleotide binding nuclear chromatin DNA binding double-stranded DNA binding ATP binding nucleus chromosome regulation of transcription, DNA-templated nucleus organization multicellular organism development spermatogenesis spermatid nucleus elongation nucleosome positioning cell differentiation chromosome condensation nucleosomal DNA binding negative regulation of chromatin silencing sperm chromatin condensation negative regulation of DNA recombination uc007xmd.1 uc007xmd.2 uc007xmd.3 uc007xmd.4 
ENSMUST00000060864.13 Tesk1 ENSMUST00000060864.13 testis specific protein kinase 1 (from RefSeq NM_011571.3) ENSMUST00000060864.1 ENSMUST00000060864.10 ENSMUST00000060864.11 ENSMUST00000060864.12 ENSMUST00000060864.2 ENSMUST00000060864.3 ENSMUST00000060864.4 ENSMUST00000060864.5 ENSMUST00000060864.6 ENSMUST00000060864.7 ENSMUST00000060864.8 ENSMUST00000060864.9 NM_011571 O70146 O70147 Q499W7 TESK1_MOUSE uc008spq.1 uc008spq.2 uc008spq.3 uc008spq.4 Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (PubMed:30115939). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (By similarity). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Activated by autophosphorylation on Ser-215. Kinase activity is inhibited by SPRED1. Interacts (via both C- and N-termini) with SPRY4 (via C- terminus); the interaction inhibits TESK1 kinase activity (By similarity). Interacts with TAOK1; the interaction inhibits TAOK1 kinase activity (By similarity). Interacts (via C-terminus) with SPRED1 (via C-terminus); the interaction inhibits TESK1 kinase activity (By similarity). Interacts (via C-terminus) with PARVA/PARVIN (via C- terminus); the interaction inhibits TESK1 kinase activity (By similarity). Interacts with YWHAB/14-3-3 beta; the interaction is dependent on the phosphorylation of TESK1 Ser-439 and inhibits TESK1 kinase activity (By similarity). Interacts with SPRY1, SPRY3 and SPRED2 (By similarity). Interacts (via C-terminus) with SPRY2 (via C- terminus); the interaction disrupts SPRY2 interaction with PPP2CA/PP2A- C, possibly by vesicular sequestration of SPRY2 (PubMed:17974561). Therefore dephosphorylation of SPRY2 by the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme is lost, inhibiting its interaction with GRB2 (By similarity). Cytoplasm Cytoplasm, perinuclear region Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cell projection, lamellipodium Note=Colocalizes with SPRY4 in vesicular spots in the cytoplasm (By similarity). Localized to F-actin- rich lamellipodia at the cell periphery following fibronectin-mediated cell adhesion of Schwann cells (By similarity). Expressed in testes and brain (at protein level). The extracatalytic C-terminal part is highly rich in proline residues. Autophosphorylated on serine and tyrosine residues. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity ATP binding nucleus cytoplasm protein phosphorylation spermatogenesis protein C-terminus binding kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation protein kinase binding actin cytoskeleton organization cytoplasmic vesicle negative regulation of protein autophosphorylation regulation of protein localization metal ion binding positive regulation of stress fiber assembly negative regulation of protein serine/threonine kinase activity uc008spq.1 uc008spq.2 uc008spq.3 uc008spq.4 
ENSMUST00000060894.9 Erich5 ENSMUST00000060894.9 glutamate rich 5 (from RefSeq NM_173421.2) ENSMUST00000060894.1 ENSMUST00000060894.2 ENSMUST00000060894.3 ENSMUST00000060894.4 ENSMUST00000060894.5 ENSMUST00000060894.6 ENSMUST00000060894.7 ENSMUST00000060894.8 ERIC5_MOUSE NM_173421 Q3TS52 Q3UX98 Q8K0S2 uc007vls.1 uc007vls.2 uc007vls.3 uc007vls.4 molecular_function cellular_component biological_process uc007vls.1 uc007vls.2 uc007vls.3 uc007vls.4 
ENSMUST00000060899.9 Napepld ENSMUST00000060899.9 N-acyl phosphatidylethanolamine phospholipase D, transcript variant 7 (from RefSeq NR_188846.1) ENSMUST00000060899.1 ENSMUST00000060899.2 ENSMUST00000060899.3 ENSMUST00000060899.4 ENSMUST00000060899.5 ENSMUST00000060899.6 ENSMUST00000060899.7 ENSMUST00000060899.8 Mbldc1 NAPEP_MOUSE NR_188846 Napepld Q8BH82 uc008wov.1 uc008wov.2 uc008wov.3 D-type phospholipase that hydrolyzes N-acyl- phosphatidylethanolamines (NAPEs) to produce bioactive N- acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:15760304, PubMed:17655883, PubMed:21801852). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (PubMed:21801852, PubMed:16605240). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (PubMed:31685899). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose (PubMed:25757720). Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (PubMed:14634025). Reaction=H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+); Xref=Rhea:RHEA:33159, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:52640, ChEBI:CHEBI:58608, ChEBI:CHEBI:62537; EC=3.1.4.54; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33160; Evidence=; Reaction=H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn- glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine; Xref=Rhea:RHEA:45620, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72860, ChEBI:CHEBI:85298, ChEBI:CHEBI:85304; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45621; Evidence=; Reaction=H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn- glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine; Xref=Rhea:RHEA:45616, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72860, ChEBI:CHEBI:85297, ChEBI:CHEBI:85303; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45617; Evidence=; Reaction=H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn- glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine; Xref=Rhea:RHEA:45612, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72860, ChEBI:CHEBI:85296, ChEBI:CHEBI:85302; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45613; Evidence=; Reaction=H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn- glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine; Xref=Rhea:RHEA:45608, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72860, ChEBI:CHEBI:85295, ChEBI:CHEBI:85301; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45609; Evidence=; Reaction=H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine; Xref=Rhea:RHEA:45556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74546, ChEBI:CHEBI:85263, ChEBI:CHEBI:85294; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45557; Evidence=; Reaction=H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine; Xref=Rhea:RHEA:45552, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74546, ChEBI:CHEBI:85262, ChEBI:CHEBI:85293; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45553; Evidence=; Reaction=H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine; Xref=Rhea:RHEA:45540, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71464, ChEBI:CHEBI:74546, ChEBI:CHEBI:78097; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45541; Evidence= Reaction=H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn- glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N- hexadecanoylethanolamine; Xref=Rhea:RHEA:45596, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71464, ChEBI:CHEBI:72860, ChEBI:CHEBI:85334; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45597; Evidence=; Reaction=H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine; Xref=Rhea:RHEA:45536, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74546, ChEBI:CHEBI:85292, ChEBI:CHEBI:85299; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45537; Evidence=; Reaction=H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine; Xref=Rhea:RHEA:45532, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71466, ChEBI:CHEBI:74546, ChEBI:CHEBI:85291; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45533; Evidence=; Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn- glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine; Xref=Rhea:RHEA:56548, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58608, ChEBI:CHEBI:140532; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56549; Evidence=; Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-ethanolamine; Xref=Rhea:RHEA:45528, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74546, ChEBI:CHEBI:85277; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45529; Evidence=; Reaction=1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho- N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z- octadecenoyl)-sn-glycero-3-phosphate + H(+) + N- hexadecanoylethanolamine; Xref=Rhea:RHEA:56464, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71464, ChEBI:CHEBI:138663, ChEBI:CHEBI:140452; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56465; Evidence=; Reaction=H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl- sn-glycero-3-phosphate + an N-acylethanolamine + H(+); Xref=Rhea:RHEA:53164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:52640, ChEBI:CHEBI:57970, ChEBI:CHEBI:85216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53165; Evidence=; Reaction=H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine = 1- hexadecanoyl-sn-glycero-3-phosphate + H(+) + N- hexadecanoylethanolamine; Xref=Rhea:RHEA:45592, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57518, ChEBI:CHEBI:71464, ChEBI:CHEBI:85335; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45593; Evidence=; Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)- sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine; Xref=Rhea:RHEA:45544, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74544, ChEBI:CHEBI:85223; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45545; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 zinc divalent cations per subunit. ; Activated by divalent cations (PubMed:17655883). Activated by bile acids (By similarity). Activated by membrane phospholipids such as phosphatidylethanolamines (PubMed:17655883). Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis. Golgi apparatus membrane ; Peripheral membrane protein Early endosome membrane ; Peripheral membrane protein Nucleus envelope Nucleus, nucleoplasm Note=Localized in the proximity of the cellular membranes likely through interaction with membrane phospholipids. Widely expressed. Highest expression in brain, spinal cord, kidney and testis (at protein level) (PubMed:14634025, PubMed:16605240). Expressed in adipose tissue (at protein level) (PubMed:25757720). Down-regulated by neurotoxin 6-hydroxydopamine. Knockout mice are born at the expected Mendelian rate (PubMed:16605240). White adipose-tissue specific knockdown (effective when differentiation of adipose tissue is complete) causes obesity, adipose tissue inflammation, insulin resistance in the liver and profound changes of gut microbiota composition. Belongs to the NAPE-PLD family. Golgi membrane temperature homeostasis phospholipase activity nucleus nuclear envelope nucleoplasm endosome early endosome Golgi apparatus cytosol lipid metabolic process phospholipid metabolic process aging zinc ion binding phospholipid catabolic process membrane lipid catabolic process hydrolase activity early endosome membrane response to isolation stress identical protein binding membrane-bounded organelle metal ion binding homeostasis of number of cells in a free-living population positive regulation of inflammatory response N-acylphosphatidylethanolamine-specific phospholipase D activity N-acylethanolamine metabolic process N-acylphosphatidylethanolamine metabolic process positive regulation of brown fat cell differentiation negative regulation of eating behavior uc008wov.1 uc008wov.2 uc008wov.3 
ENSMUST00000060904.11 Tceal3 ENSMUST00000060904.11 transcription elongation factor A (SII)-like 3, transcript variant 4 (from RefSeq NM_001359279.1) A2AEC3 ENSMUST00000060904.1 ENSMUST00000060904.10 ENSMUST00000060904.2 ENSMUST00000060904.3 ENSMUST00000060904.4 ENSMUST00000060904.5 ENSMUST00000060904.6 ENSMUST00000060904.7 ENSMUST00000060904.8 ENSMUST00000060904.9 NM_001359279 Q8R0A5 Q9CYK5 Q9D1S4 TCAL3_MOUSE uc009uir.1 uc009uir.2 uc009uir.3 uc009uir.4 May be involved in transcriptional regulation. Nucleus Belongs to the TFS-II family. TFA subfamily. nucleus WW domain binding uc009uir.1 uc009uir.2 uc009uir.3 uc009uir.4 
ENSMUST00000060913.8 Dusp28 ENSMUST00000060913.8 dual specificity phosphatase 28 (from RefSeq NM_175118.3) DUS28_MOUSE ENSMUST00000060913.1 ENSMUST00000060913.2 ENSMUST00000060913.3 ENSMUST00000060913.4 ENSMUST00000060913.5 ENSMUST00000060913.6 ENSMUST00000060913.7 NM_175118 Q8BTR5 uc007cbu.1 uc007cbu.2 uc007cbu.3 Has phosphatase activity with the synthetic substrate 6,8- difluoro-4-methylumbelliferyl phosphate (in vitro). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine. The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Monomer. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc007cbu.1 uc007cbu.2 uc007cbu.3 
ENSMUST00000060918.11 Amz1 ENSMUST00000060918.11 archaelysin family metallopeptidase 1 (from RefSeq NM_173405.2) AMZ1_MOUSE ENSMUST00000060918.1 ENSMUST00000060918.10 ENSMUST00000060918.2 ENSMUST00000060918.3 ENSMUST00000060918.4 ENSMUST00000060918.5 ENSMUST00000060918.6 ENSMUST00000060918.7 ENSMUST00000060918.8 ENSMUST00000060918.9 NM_173405 Q811F9 Q8BMM5 Q8BVF9 uc009aif.1 uc009aif.2 uc009aif.3 Probable zinc metalloprotease. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role. ; Belongs to the peptidase M54 family. Sequence=BAC27003.1; Type=Erroneous initiation; Evidence=; cellular_component proteolysis peptidase activity metallopeptidase activity hydrolase activity metal ion binding uc009aif.1 uc009aif.2 uc009aif.3 
ENSMUST00000060930.10 Ccdc158 ENSMUST00000060930.10 coiled-coil domain containing 158, transcript variant 2 (from RefSeq NM_177230.3) CD158_MOUSE ENSMUST00000060930.1 ENSMUST00000060930.2 ENSMUST00000060930.3 ENSMUST00000060930.4 ENSMUST00000060930.5 ENSMUST00000060930.6 ENSMUST00000060930.7 ENSMUST00000060930.8 ENSMUST00000060930.9 NM_177230 Q3TU97 Q8CDI6 uc008ydr.1 uc008ydr.2 uc008ydr.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CDI6-1; Sequence=Displayed; Name=2; IsoId=Q8CDI6-2; Sequence=VSP_032393, VSP_032394; molecular_function cellular_component biological_process uc008ydr.1 uc008ydr.2 uc008ydr.3 
ENSMUST00000060943.5 Chrnb3 ENSMUST00000060943.5 cholinergic receptor, nicotinic, beta polypeptide 3, transcript variant 1 (from RefSeq NM_173212.4) ACHB3_MOUSE ENSMUST00000060943.1 ENSMUST00000060943.2 ENSMUST00000060943.3 ENSMUST00000060943.4 NM_173212 Q8BMN3 Q8R5H3 Q9CYK8 uc009lit.1 uc009lit.2 uc009lit.3 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR seems to be composed of two different types of subunits: alpha and beta. Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BMN3-1; Sequence=Displayed; Name=2; IsoId=Q8BMN3-2; Sequence=VSP_013775; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub- subfamily. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane integral component of plasma membrane acetylcholine-gated channel complex ion transport signal transduction chemical synaptic transmission synaptic transmission, cholinergic neuromuscular synaptic transmission drug binding membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction ion transmembrane transport response to nicotine acetylcholine binding regulation of membrane potential neuron projection synapse postsynaptic membrane neurological system process protein heterooligomerization regulation of postsynaptic membrane potential excitatory postsynaptic potential regulation of synaptic vesicle exocytosis acetylcholine receptor activity uc009lit.1 uc009lit.2 uc009lit.3 
ENSMUST00000060945.12 Aff4 ENSMUST00000060945.12 AF4/FMR2 family, member 4, transcript variant 1 (from RefSeq NM_033565.2) AFF4_MOUSE Alf4 B2RST9 ENSMUST00000060945.1 ENSMUST00000060945.10 ENSMUST00000060945.11 ENSMUST00000060945.2 ENSMUST00000060945.3 ENSMUST00000060945.4 ENSMUST00000060945.5 ENSMUST00000060945.6 ENSMUST00000060945.7 ENSMUST00000060945.8 ENSMUST00000060945.9 NM_033565 Q8C6K4 Q8C6W3 Q8CCH3 Q9ESC8 uc007ivu.1 uc007ivu.2 uc007ivu.3 uc007ivu.4 Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity). Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with ELL2; the interaction is direct and leads to stabilize ELL2 and prevent ELL2 ubiquitination and degradation (By similarity). Interacts with ELL3; the interaction is direct. Nucleus Note=Associates to transcriptionally active chromatin but not at snRNA genes. Highly expressed in testis by Sertoli cells, and at low levels in other tissues. Expressed throughout embryogenesis with maximum expression at 10.5 and 12.5 dpc. Mice are infertile with azoospermia. Spermatogenesis is arrested at the level of spermiogenesis. Belongs to the AF4 family. Sequence=BAC28178.1; Type=Frameshift; Evidence=; Sequence=BAC35763.1; Type=Frameshift; Evidence=; fibrillar center double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated spermatid development transcription elongation factor complex ELL-EAF complex transcriptionally active chromatin uc007ivu.1 uc007ivu.2 uc007ivu.3 uc007ivu.4 
ENSMUST00000060972.5 Kcna5 ENSMUST00000060972.5 potassium voltage-gated channel, shaker-related subfamily, member 5 (from RefSeq NM_145983.2) ENSMUST00000060972.1 ENSMUST00000060972.2 ENSMUST00000060972.3 ENSMUST00000060972.4 KCNA5_MOUSE NM_145983 Q61762 Q9Z1R6 uc009dva.1 uc009dva.2 uc009dva.3 uc009dva.4 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:8226976, PubMed:11349004). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8226976, PubMed:11349004). May play a role in regulating the secretion of insulin in normal pancreatic islets (By similarity). Homotetramer and heterotetramer of potassium channel proteins. Interacts with DLG1, which enhances channel currents. Forms a ternary complex with DLG1 and CAV3 (By similarity). Interacts with KCNAB1 (By similarity). Interacts with UBE2I (By similarity). Q61762; Q4U4S6: Xirp2; NbExp=2; IntAct=EBI-26520959, EBI-10768169; Cell membrane ulti-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q61762-1; Sequence=Displayed; Name=2; Synonyms=5'; IsoId=Q61762-2; Sequence=VSP_000961; Name=3; Synonyms=3'; IsoId=Q61762-3; Sequence=VSP_000962; Highly expressed in heart and moderately in brain. Low levels in thymus, skeletal muscle and spleen. Not expressed in liver, lung or kidney. The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. Sumoylated on Lys-212, and Lys-525, preferentially with SUMO3. Sumoylation regulates the voltage sensitivity of the channel (By similarity). No visible phenotype. The action potential in myocytes is not prolonged by low concentrations of 4-aminopyridine, contrary to the situation in wild-type. [Isoform 3]: Inactive. Inhibits expression of isoform 1 and isoform 2. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily. response to hypoxia receptor binding ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity protein binding endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane ion transport potassium ion transport Notch signaling pathway voltage-gated potassium channel complex response to mechanical stimulus cell surface response to organic substance intercalated disc outward rectifier potassium channel activity membrane integral component of membrane regulation of vasoconstriction potassium channel inhibitor activity protein kinase binding Z disc potassium channel complex regulation of ion transmembrane transport regulation of membrane potential response to hydrogen peroxide regulation of potassium ion transport negative regulation of potassium ion transport membrane raft intracellular canaliculus perinuclear region of cytoplasm protein oligomerization protein homooligomerization alpha-actinin binding negative regulation of cytosolic calcium ion concentration potassium ion homeostasis transmembrane transport response to hyperoxia membrane hyperpolarization regulation of atrial cardiac muscle cell membrane repolarization potassium ion transmembrane transport atrial cardiac muscle cell action potential membrane repolarization during bundle of His cell action potential membrane repolarization during SA node cell action potential voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in SA node cell action potential repolarization regulation of heart rate by cardiac conduction scaffold protein binding potassium ion export across plasma membrane membrane repolarization during atrial cardiac muscle cell action potential positive regulation of G1/S transition of mitotic cell cycle positive regulation of myoblast proliferation uc009dva.1 uc009dva.2 uc009dva.3 uc009dva.4 
ENSMUST00000060989.9 Sorl1 ENSMUST00000060989.9 sortilin-related receptor, LDLR class A repeats-containing, transcript variant 1 (from RefSeq NM_011436.4) ENSMUST00000060989.1 ENSMUST00000060989.2 ENSMUST00000060989.3 ENSMUST00000060989.4 ENSMUST00000060989.5 ENSMUST00000060989.6 ENSMUST00000060989.7 ENSMUST00000060989.8 NM_011436 O54711 O70581 O88307 Q3UHM3 SORL_MOUSE uc009pap.1 uc009pap.2 uc009pap.3 Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic reticulum to Golgi compartments (By similarity). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling by controlling the intracellular location of its receptor (PubMed:23977241). Sorting receptor for GDNF that promotes GDNF regulated, but not constitutive secretion (PubMed:21994944). Sorting receptor for the GDNF-GFRA1 complex, directing it from the cell surface to endosomes. GDNF is then targeted to lysosomes and degraded, while its receptor GFRA1 recycles back to the cell membrane, resulting in a GDNF clearance pathway. The SORL1-GFRA1 complex further targets RET for endocytosis, but not for degradation, affecting GDNF-induced neurotrophic activities (PubMed:23333276). Sorting receptor for ERBB2/HER2. Regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulating phosphoinositide 3-kinase (PI3K)-dependent ERBB2 signaling (By similarity). Sorting receptor for lipoprotein lipase LPL. Promotes LPL localization to endosomes and later to the lysosomes, leading to degradation of newly synthesized LPL (By similarity). Potential sorting receptor for APOA5, inducing APOA5 internalization to early endosomes, then to late endosomes, wherefrom a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network (By similarity). Sorting receptor for the insulin receptor INSR. Promotes recycling of internalized INSR via the Golgi apparatus back to the cell surface, thereby preventing lysosomal INSR catabolism, increasing INSR cell surface expression and strengthening insulin signal reception in adipose tissue. Does not affect INSR internalization (PubMed:27322061). Plays a role in renal ion homeostasis, controlling the phospho-regulation of SLC12A1/NKCC2 by STK39/SPAK kinase and PPP3CB/calcineurin A beta phosphatase, possibly through intracellular sorting of STK39 and PPP3CB (PubMed:20385770, PubMed:25967121). Stimulates, via the N-terminal ectodomain, the proliferation and migration of smooth muscle cells, possibly by increasing cell surface expression of the urokinase receptor uPAR/PLAUR. This may promote extracellular matrix proteolysis and hence facilitate cell migration (By similarity). By acting on the migration of intimal smooth muscle cells, may accelerate intimal thickening following vascular injury (PubMed:14764453). Promotes adhesion of monocytes (By similarity). Stimulates proliferation and migration of monocytes/macrophages. Through its action on intimal smooth muscle cells and macrophages, may accelerate intimal thickening and macrophage foam cell formation in the process of atherosclerosis (PubMed:17332490). Regulates hypoxia-enhanced adhesion of hematopoietic stem and progenitor cells to the bone marrow stromal cells via a PLAUR- mediated pathway. This function is mediated by the N-terminal ectodomain (PubMed:23486467). Metabolic regulator, which functions to maintain the adequate balance between lipid storage and oxidation in response to changing environmental conditions, such as temperature and diet. The N-terminal ectodomain negatively regulates adipose tissue energy expenditure, acting through the inhibition the BMP/Smad pathway (PubMed:26584636). May regulate signaling by the heterodimeric neurotrophic cytokine CLCF1-CRLF1 bound to the CNTFR receptor by promoting the endocytosis of the tripartite complex CLCF1-CRLF1-CNTFR and lysosomal degradation (PubMed:26858303). May regulate IL6 signaling, decreasing cis signaling, possibly by interfering with IL6- binding to membrane-bound IL6R, while up-regulating trans signaling via soluble IL6R (PubMed:28265003). After maturation cleavage, interacts (via N-terminus) with its own propeptide; this interaction prevents interaction with other ligands, including CRLF1, GDNF, GFRA1, IL6 and IL6R (By similarity). Interacts (via N-terminal ectodomain) with APP, forming a 1:1 stoichiometric complex, including with isoforms APP695, APP751 and APP770; this interaction retains APP in the trans-Golgi network and reduces processing into soluble APP-alpha and amyloid-beta peptides (PubMed:16174740, PubMed:16407538). Also interacts with APP C-terminal fragment C99 and with Abeta40 (By similarity). Interacts with beta- secretase BACE1/BACE; this interaction may affect BACE1-binding to APP and hence reduce BACE1-dependent APP cleavage (PubMed:16407538). Interacts with LRPAP1/RAP (By similarity). Interacts (via C-terminal cytosolic domain) with GGA1 and GGA2 (via N-terminal VHS domain) (By similarity). Interacts with PACS1 (By similarity). May interact (via the N-terminal ectodomain) with the morphogenetic neuropeptide, also called head activator or HA; this interaction is impaired in the presence of propeptide (By similarity). Interacts with neurotensin/NTS (By similarity). Interacts (via the N-terminal ectodomain) with PDGFB homodimer (By similarity). Interacts (via N-terminal ectodomain) with the uPA receptor PLAUR (By similarity). Interacts with uPA/PLAU and PAI1/SERPINE1, either individually or in complex with each other, leading to endocytosis (By similarity). Also interacts with PAI1/SERPINE1 in complex with tPA/PLAT. Interacts (via C-terminus) with AP-1 and AP-2 complexes (By similarity). Interacts with BMPR1A and BMPR1B (PubMed:26584636). Interacts with lipoprotein lipase LPL; this interaction is optimal in slightly acidic conditions (By similarity). Interacts (via N-terminal ectodomain) with GDNF (via propeptide) and GDNF receptor alpha-1/GFRA1, either individually or in complex with each other (By similarity). The interaction with GDNF occurs mostly intracellularly (By similarity). Also interacts with other GDNF receptor alpha family members, including GFRA2, GFRA3 and GFRA4 (By similarity). Interacts with the insulin receptor INSR; this interaction strongly increases the surface exposure of INSR (PubMed:27322061). Interacts (via cytosolic C-terminus) with STK39/SPAK (By similarity). Interacts (via N-terminal ectodomain) with the heterodimeric complex CRLF1-CLC; within this complex, the interaction is mediated predominantly by the CRLF1 moiety (By similarity). Interacts with CNTFR, as well as with the tripartite signaling complex formed by CRLF1, CLC and CNTFR (By similarity). Interacts (via N-terminal ectodomain) with IL6; this interaction leads to IL6 internalization and lysosomal degradation. Binding of SOLRL1 secreted N-terminal ectodomain to IL6 may increase IL6 trans signaling (By similarity). Interacts with secreted IL6R; this interaction leads to IL6R internalization (PubMed:28265003). Also interacts with transmembrane IL6R; this interaction does not affect subcellular location. Interacts with APOE (By similarity). Interacts with apolipoprotein E-rich beta-VLDL (By similarity). Interacts with APOA5; this interaction leads to APOA5 internalization and is abolished by heparin. Interaction with APOA5 results in enhanced binding to chylomicrons. Interacts with ROCK2 (By similarity). Interacts (via cytosolic C-terminus) with PPP3CB/calcineurin A beta (PubMed:25967121). Interacts with NTRK2/TRKB; this interaction facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling (PubMed:23977241). Interacts (via cytosolic C- terminus) with HSPA12A in an ADP-dependent manner; this interaction affects SORL1 internalization and subcellular localization (By similarity). Interacts (via N-terminal ectodomain) with ERBB2/HER2 (By similarity). O88307; P12023: App; NbExp=3; IntAct=EBI-7540114, EBI-78814; O88307; Q9EQH3: Vps35; NbExp=2; IntAct=EBI-7540114, EBI-775825; Golgi apparatus membrane ; Single-pass type I membrane protein Golgi apparatus, trans-Golgi network membrane ; Single-pass type I membrane protein Endosome membrane ; Single-pass type I membrane protein Early endosome membrane ; Single-pass type I membrane protein Recycling endosome membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Endosome, multivesicular body membrane ; Single-pass type I membrane protein Cell membrane ; Single-pass type I membrane protein Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass type I membrane protein Secreted Note=Mostly intracellular, predominantly in the trans-Golgi network (TGN) and in endosome, as well as in endosome-to-TGN recycling compartments; found at low levels on the plasma membrane (By similarity). At the cell surface, partially subjected to proteolytic shedding that releases the ectodomain (also called soluble SORLA, solLR11 or sLR11) in the extracellular milieu (PubMed:11082041). The shedding may be catalyzed by ADAM17/TACE. Following shedding, PSEN1/presenilin-1 cleaves the remaining transmembrane fragment and catalyzes the release of a C- terminal fragment in the cytosol and of a soluble N-terminal beta fragment in the extracellular milieu. The C-terminal cytosolic fragment localizes to the nucleus. At the cell surface, the full-length protein undergoes partial clathrin-dependent endocytosis guided by clathrin adapter protein 2 (AP-2) (By similarity). Highly expressed in the central nervous system, including in the brain and spinal cord, in neurons, as well as in glial cells (at protein level) (PubMed:9726247, PubMed:9510025, PubMed:11082041, PubMed:16174740, PubMed:21385844, PubMed:23333276, PubMed:23977241, PubMed:30679749). In the brain, mainly expressed in the cerebellum, hippocampus, dentate gyrus, hypothalamus, and in the cerebral cortex (at protein level) (PubMed:9726247, PubMed:9510025, PubMed:23333276, PubMed:27322061). Also detected in kidney, heart, lung and spleen (PubMed:9726247, PubMed:9510025). In the kidney, expressed in epithelial cells in the thick ascending limb of Henle's loop, the distal convoluted tubule, the connecting tubule and the cortical collecting duct (at protein level) (PubMed:20385770, PubMed:25967121). Expressed in skeletal muscle (at protein level) (PubMed:9726247, PubMed:9510025, PubMed:27322061). Expressed in adipose tissue, including in brown adipose tissue and subcutaneous white adipose tissue (PubMed:26584636, PubMed:27322061). Expressed in intimal smooth muscle cells (at protein level) (PubMed:14764453). Expression starts at 6.5 dpc (PubMed:9726247, PubMed:9510025). At 7.5 dpc, expressed over the entire embryo, with highest levels in the amnion. Up to 8.5 dpc, expression further increases and becomes more restricted to the foregut and the amnion. At 9.5 dpc, expression increases in the somites, as well as the developing gut, and is observed over the facial-cranial mesenchyme and the branchial arches. At 10.5 dpc, expression in the mesenchyme and the somites reaches its maximal intensity. At this stage, highest expression level is observed over the ventral part of the neural tube, in the marginal zone, and extends throughout the hindbrain. Also expressed in motor neurons of the spinal cord. With ongoing development, the brain becomes the main site of expression. At 11.5 dpc, expressed in the telencephalon, being restricted to the lateral aspects of the developing cerebral cortex, with highest levels in the outer layer of the neuronal tissue of the developing cerebral cortex. Also observed in the myelencephalon and in a thin cell layer in the rhombic lip of the metencephalon. At 12.5 dpc, expression begins in the mesencephalon and the diencephalon. Up to 14.5 dpc, expression levels in the developing cerebral cortex become more even and spread to more dorsal and caudal locations. At 14.5 dpc, decreased expression in the metencephalon and the myelencephalon. At 16.5 dpc, expressed over the entire cortical area, although at a slightly lower intensity. Expressed in the hypothalamus. At this stage, expression begins in the peripheral nervous system, including in the trigeminal ganglion, the dorsal root ganglia, the cochlear-vestibular ganglia and the sympathetic ganglia chain, but at lower levels compared to the central nervous system. Expressed over the mitral cell layer of the olfactory bulb and between the 2 outer walls of the gut. The overall expression levels in the cortex decrease until birth. At 18.5 dpc, the outer aspects of the cortical plate shows lower expression levels than the subventricular zone. At 18.5 dpc, expressed in the retina and the geniculate nucleus of the thalamus; this expression increases towards P0. At P0, expression levels are higher in the outer aspects of the cortical plate than in the subventricular zone (PubMed:9510025). 1 week after birth, abundantly expressed in the cerebrum, then levels decrease and become nearly undetectable at 4 weeks. Expression increases again and reaches moderate levels at 12 weeks. In the cerebellum, expressed at high levels during the first 2 weeks. Expression decreases at 4 and 8 weeks, and then increases again at 12 weeks (PubMed:9726247). Expressed in many organs outside the nervous system during organogenesis, such as the primitive gut where expression is detected already at 8.5 dpc. Other SORL1-expressing organs include the genital bud, the mesenchymal tissue, the developing skeletal muscles, the myocardium, the pituitary, the pineal, the thyroid and the Haderian glands, as well as the developing serous glands of the nasal cavity, the salivary and the submandibular glands, the pancreas, the epithelia of the stomach, the tubules of the kidney, the tooth germ, the cochlea, the nasal cavity, the trachea, the lung, the bladder and urethra, the intestine and the rectum (PubMed:9510025). Up-regulated by BDNF in cortical neurons (at protein level) (PubMed:20007471). Up-regulated under hypoxic conditions in hematopoietic stem and progenitor cells, a physiological conditions encountered by these cells in the endosteum (at protein level) (PubMed:23486467). In brown and sucutaneous white adipose tissues, down-regulated when environmental temperature rises from cold to thermoneutrality (PubMed:26584636). Up-regulated in adipose tissue by insulin through a post-transcriptional mechanism (PubMed:27322061). Expression levels increase in the fed state and decline after fasting (PubMed:26584636). Within the Golgi apparatus, the propeptide may be cleaved off by FURIN or a furin-like protease. After cleavage, the propeptide interacts with the mature protein N-terminus, preventing the association with other ligands. At the cell surface, partially subjected to proteolytic shedding that releases the ectodomain in the extracellular milieu. The shedding may be catalyzed by ADAM17/TACE. Following shedding, PSEN1/presenilin-1 cleaves the remaining transmembrane fragment and catalyzes the release of a C-terminal fragment in the cytosol and of a soluble N-terminal beta fragment in the extracellular milieu. The C-terminal cytosolic fragment localizes to the nucleus. Phosphorylation at Ser-2207 facilitates the interaction with GGA1. Knockout mice are viable and fertile with no overt phenotype (PubMed:16174740). They tend to be lighter than their wild-type littermates, with reduced adiposity (PubMed:26584636, PubMed:27322061). On a high-fat diet, they show a reduced gain in body weight compared with wild-type littermates (PubMed:27322061). Mutant animals display improved serum biochemistry profiles compared to wild- type, with lower fasting glucose, insulin and triglyceride levels, particularly on high fat diet (PubMed:26584636, PubMed:27322061). On a high-fat diet, brown adipose tissue from knockout mice shows reduced lipid content and subcutaneous white adipose tissue contains smaller, less lipid replete adipocytes, with increased thermogenic markers (PubMed:26584636). Mutant animals exhibit an increased production of soluble APP and enhanced amount of neuron-associated amyloid-beta protein 40 and 42 in the brain at 10 months of age (PubMed:16174740). Following vascular injury, knockout mice placed on a high-fat diet show reduced intimal thickness and decreased infiltration of lipid-laden macrophages compared to wild-type littermates (PubMed:17332490). Mutant mice display elevated GDNF levels, altered dopaminergic function, marked hyperactivity, and reduced anxiety (PubMed:23333276). Knockout mice show a weak phenotype in the maintenance of renal ion balance. Under basal conditions, they exhibit significant urinary loss of potassium and calcium compared to controls. Serum Na(+), Cl(-), and K(+) levels are normal, but aldosterone levels are elevated 2-fold. Mean arterial blood pressure is decreased despite the hyperaldosteronemic phenotype (PubMed:20385770). The lack of major renal phenotype in mutant mice may be explained by the fact that animals remain responsive to vasopressin endocrine stimulation (PubMed:25967121). Belongs to the VPS10-related sortilin family. SORL1 subfamily. Golgi membrane beta-amyloid binding diet induced thermogenesis protein binding extracellular region extracellular space nuclear envelope lumen endosome early endosome multivesicular body endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus trans-Golgi network plasma membrane protein targeting protein targeting to lysosome post-Golgi vesicle-mediated transport endocytosis multicellular organism development endosome membrane negative regulation of triglyceride catabolic process regulation of smooth muscle cell migration membrane integral component of membrane cell migration low-density lipoprotein particle binding ADP-ribosylation factor binding negative regulation of BMP signaling pathway transport vesicle membrane cytoplasmic vesicle early endosome membrane Golgi cisterna negative regulation of protein binding negative regulation of protein oligomerization multivesicular body membrane protein localization to Golgi apparatus insulin receptor recycling neuronal cell body negative regulation of MAP kinase activity protein retention in Golgi apparatus positive regulation of protein catabolic process positive regulation of insulin receptor signaling pathway perinuclear region of cytoplasm negative regulation of neurogenesis protein maturation recycling endosome recycling endosome membrane positive regulation of protein exit from endoplasmic reticulum positive regulation of glial cell-derived neurotrophic factor secretion negative regulation of neuron death negative regulation of beta-amyloid formation positive regulation of choline O-acetyltransferase activity negative regulation of tau-protein kinase activity positive regulation of ER to Golgi vesicle-mediated transport positive regulation of early endosome to recycling endosome transport negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process positive regulation of protein localization to early endosome negative regulation of neurofibrillary tangle assembly positive regulation of adipose tissue development adaptive thermogenesis positive regulation of endocytic recycling uc009pap.1 uc009pap.2 uc009pap.3 
ENSMUST00000060991.6 Tspan31 ENSMUST00000060991.6 tetraspanin 31 (from RefSeq NM_025982.4) ENSMUST00000060991.1 ENSMUST00000060991.2 ENSMUST00000060991.3 ENSMUST00000060991.4 ENSMUST00000060991.5 NM_025982 Q9CQ88 Q9CUY7 Sas TSN31_MOUSE uc007hhw.1 uc007hhw.2 uc007hhw.3 Membrane ; Multi-pass membrane protein Belongs to the tetraspanin (TM4SF) family. molecular_function membrane integral component of membrane uc007hhw.1 uc007hhw.2 uc007hhw.3 
ENSMUST00000060992.6 Rtn4 ENSMUST00000060992.6 reticulon 4, transcript variant 4 (from RefSeq NM_024226.4) ENSMUST00000060992.1 ENSMUST00000060992.2 ENSMUST00000060992.3 ENSMUST00000060992.4 ENSMUST00000060992.5 Kiaa0886 NM_024226 Nogo Q5DTK9 Q78NS1 Q7TNB7 Q80W95 Q8BGK7 Q8BGM9 Q8BH78 Q8BHF5 Q8K290 Q8K3G8 Q99P72 Q9CTE3 RTN4_MOUSE Rtn4 uc007iho.1 uc007iho.2 uc007iho.3 uc007iho.4 Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities. [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system (PubMed:20573699). Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (By similarity). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (PubMed:20573699). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (PubMed:23625008). [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells (PubMed:15034570). Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate- limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P) (PubMed:26301690). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair (PubMed:19805174). Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation (PubMed:21183689). Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes (PubMed:25917084). Also involved in immune response to LPS (PubMed:26174362). Plays a role in liver regeneration through the modulation of hepatocytes proliferation (PubMed:23299899). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (By similarity). [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (PubMed:27763637). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (By similarity). Binds to RTN4R (By similarity). Interacts with ATL1 (By similarity). Interacts with TMEM170A (By similarity). Interacts with RTN4IP1 (PubMed:12067236). [Isoform A]: Interacts in trans with CNTNAP1 (By similarity). Interacts with REEP5 (PubMed:32075961). Interacts with GPR50 (By similarity). Interacts with synaptic plasticity regulator PANTS; the interaction results in enhanced RTN4-mediated inhibition of AMPA receptor clustering (PubMed:35771867). [Isoform B]: Homodimer (By similarity). Interacts with BAD/Bcl-xl and BCL2. Interact with RTN3 (By similarity). Interacts with NGBR (By similarity). Interacts with SPTLC1 (PubMed:26301690). Interacts with GRAMD4 (PubMed:25917084). Interacts with CDH5 (By similarity). Interacts with BACE1 and BACE2 (By similarity). Interacts with REEP5 (PubMed:32075961). Interacts with RETREG3 (By similarity). [Isoform C]: Interacts with BACE1 and BACE2 (By similarity). Interacts with TMEM33 (By similarity). Q99P72; P48722: Hspa4l; NbExp=4; IntAct=EBI-3869532, EBI-8314699; Q99P72; P52592: S1pr2; NbExp=2; IntAct=EBI-3869532, EBI-16091339; [Isoform A]: Endoplasmic reticulum membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein ; Cytoplasmic side Synapse Note=Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network. Co-localizes with TMEM33 at the ER sheets. [Isoform B]: Endoplasmic reticulum membrane ulti-pass membrane protein Cell membrane ; Multi-pass membrane protein ; Extracellular side Cell junction Note=Mainly located on endoplasmic reticulum tubules and sheet edges (PubMed:27786289). Upon ICAM1 engagement, redistributed toward endothelial junctions where interacts with CDH5 (By similarity). [Isoform C]: Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=5; Name=A; Synonyms=RTN4A ogo-A TN-xL ; IsoId=Q99P72-2; Sequence=Displayed; Name=D; Synonyms=RTN4D ogo-D IsoId=Q99P72-3; Sequence=VSP_018089, VSP_018090; Name=C; Synonyms=RTN4C ogo-C IsoId=Q99P72-1; Sequence=VSP_018088, VSP_018091; Name=B2; Synonyms=RTN4B2 , Nogo-B2 ; IsoId=Q99P72-4; Sequence=VSP_060063; Name=B; Synonyms=RTN4B , Nogo-B , RTN4B1 , Nogo-B1 ; IsoId=Q99P72-5; Sequence=VSP_060062; [Isoform A]: Expressed in cardiomyocytes (at protein level) (PubMed:32075961). Highly expressed in brain but not deteceted in aorta, femoral and carotid arteries (PubMed:15034570). Main isoform expressed in neurons (PubMed:23625008, PubMed:27786289). [Isoform B]: Expressed in cardiomyocytes (at protein level) (PubMed:32075961). Expressed in splenocytes, T-cells, B- cells, bone marrow derived dendritic cells and macrophages (at protein level) (PubMed:19805174, PubMed:25917084). Expressed in neurons (PubMed:23625008, PubMed:27786289). Highly expressed in endothelial cells and vascular smooth muscle cells, including blood vessels and mesenteric arteries (PubMed:15034570, PubMed:26301690). Expressed in bronchial and alveolar epithelial cells as well as vascular endothelial cells of lungs (PubMed:26174362). [Isoform B2]: Expressed in B-cells, bone marrow dendritic cells and macrophages (at protein level). [Isoform C]: Expressed in cardiomyocytes. [Isoform D]: Expressed at very low levels in neurons. Expressed in radial glial cells, migrating postmitotic as well as postmigratory neurons of the embryonic cortex (PubMed:20093372). Expression is down-regulated in the ganglion cell layer and in the plexiform layer of the retina at P8 (PubMed:20093372). Isoform B: expression increases in regenirating liver (PubMed:23299899). Isoform C: expression is induced by hypoxic treatments or myocardial infarction (PubMed:27763637). Isoform C: is negatively regulated by the microRNA miR-182 (PubMed:27763637). Isoform B: expression is down-regulated by LPS in alveolar epithelium (PubMed:26174362). Isoform B: induced during tissue ischemia (PubMed:19805174). Isoform B2: induced during tissue ischemia (PubMed:19805174). Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity). [Isoform B]: N-terminal part, called Am-Nogo-B(1-200), is the functional domain for RTN4B-mediated signaling in endothelial and vascular smooth muscle cells. Isoform A mutant embryos show defects in the development of fore- and hindlimb innervation. Increased fasciculation and decreased branching of nerves innervating fore- and hindlimbs seen. Disturbances of the radial migration pattern of neuronal precursor cells seen in embryonic cortex (PubMed:20093372, PubMed:20573699). Isoform A mutants show increased density of blood vessels in postnatal brain, which is lost in adult brain (PubMed:23625008). Knockout mice for isoforms A and B are markedly hypotensive compared to control mice, with no significant increase of heart rate. They have mesenteric arteries thinner than controls (PubMed:26301690). Upon vascular injury mutants show markedly enhanced neointima formation and, in some cases, complete occlusion of the femoral artery (PubMed:15034570). Mutants for isoforms A and B show a marked reduction in neutrophil and monocyte recruitment to sites of inflammation (PubMed:21183689). Mutants for isoforms A and B are insensitive to stimulation with TLR9, TLR3 and TLR7 ligands (PubMed:25917084). Mutant mice for isoform C display improved cardiac function, smaller infarct area and less apoptotic cells after myocardial infarction (PubMed:27763637). Knockout mice show impaired responses to tissue injury (PubMed:19805174). Sequence=AAH32192.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BC056373; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Name=Protein Spotlight; Note=Nerve regrowth: nipped by a no-go - Issue 69 of April 2006; URL="https://web.expasy.org/spotlight/back_issues/069"; blastocyst formation leukocyte migration involved in inflammatory response protein binding nuclear envelope cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane endoplasmic reticulum organization nervous system development axonal fasciculation positive regulation of epithelial cell migration negative regulation of neuron projection development postsynaptic density membrane integral component of membrane cerebral cortex radial glia guided migration central nervous system vasculogenesis cell junction integral component of endoplasmic reticulum membrane negative regulation of cell growth regulation of cell migration axon negative regulation of axon extension ubiquitin protein ligase binding macromolecular complex positive regulation of mammary gland epithelial cell proliferation positive regulation of dopamine secretion positive regulation of toll-like receptor 9 signaling pathway positive regulation of Rac protein signal transduction cell migration involved in vasculogenesis protein homodimerization activity cell projection neuron projection neuronal cell body myelin sheath dendritic growth cone macromolecular complex binding cadherin binding negative regulation of neuron differentiation positive regulation of glial cell differentiation positive regulation of angiogenesis positive regulation of collateral sprouting of injured axon negative regulation of axonogenesis protein stabilization nuclear pore complex assembly positive regulation of protein kinase B signaling regulation of sensory perception of pain regulation of nervous system development cardiac epithelial to mesenchymal transition positive regulation of macrophage cytokine production protein localization to lysosome negative regulation of neuron projection regeneration cellular response to hypoxia endoplasmic reticulum tubular network endoplasmic reticulum tubular network organization endoplasmic reticulum tubular network assembly cellular sphingolipid homeostasis endoplasmic reticulum tubular network membrane glutamatergic synapse integral component of postsynaptic density membrane positive regulation of neutrophil migration negative regulation of dendrite extension positive regulation of macrophage migration positive regulation of protein localization to endoplasmic reticulum positive regulation of ERBB3 signaling pathway positive regulation of artery morphogenesis endoplasmic reticulum tubular network membrane organization regulation of branching morphogenesis of a nerve positive regulation of hepatocyte proliferation negative regulation of vasculogenesis uc007iho.1 uc007iho.2 uc007iho.3 uc007iho.4 
ENSMUST00000061019.6 Kif2b ENSMUST00000061019.6 kinesin family member 2B (from RefSeq NM_028547.3) ENSMUST00000061019.1 ENSMUST00000061019.2 ENSMUST00000061019.3 ENSMUST00000061019.4 ENSMUST00000061019.5 KIF2B_MOUSE NM_028547 Q8C0N1 uc007kxf.1 uc007kxf.2 uc007kxf.3 Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement during mitosis. Has microtubule depolymerization activity. Plays a role in chromosome congression. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Chromosome, centromere, kinetochore Note=Association with kinetochore is transient. Phosphorylation at Thr-125 by PLK1 is required for activity in the correction of kinetochore-microtubules attachment errors, while phosphorylation at Ser-204 also by PLK1 is required for the kinetochore localization and activity in prometaphase. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily. nucleotide binding chromosome, centromeric region kinetochore condensed chromosome kinetochore microtubule motor activity ATP binding nucleus chromosome nucleolus cytoplasm centrosome microtubule organizing center spindle cytoskeleton kinesin complex microtubule microtubule-based movement microtubule depolymerization cell cycle microtubule binding microtubule cytoskeleton ATPase activity intercellular bridge cell division metaphase plate congression regulation of chromosome segregation mitotic spindle uc007kxf.1 uc007kxf.2 uc007kxf.3 
ENSMUST00000061030.10 Rtp2 ENSMUST00000061030.10 receptor transporter protein 2 (from RefSeq NM_001008230.3) ENSMUST00000061030.1 ENSMUST00000061030.2 ENSMUST00000061030.3 ENSMUST00000061030.4 ENSMUST00000061030.5 ENSMUST00000061030.6 ENSMUST00000061030.7 ENSMUST00000061030.8 ENSMUST00000061030.9 Gm605 NM_001008230 Q80ZI2 RTP2_MOUSE uc007yty.1 uc007yty.2 Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs. Interacts with olfactory receptors. Cell membrane ; Single-pass type III membrane protein Note=Effective cell surface expression depends upon interaction with olfactory receptors. Predominantly expressed in olfactory and vomeronasal organs, in mature olfactory sensory neurons. Belongs to the TMEM7 family. detection of chemical stimulus involved in sensory perception of bitter taste plasma membrane protein targeting to membrane cell surface membrane integral component of membrane olfactory receptor binding protein insertion into membrane uc007yty.1 uc007yty.2 
ENSMUST00000061035.4 Ferd3l ENSMUST00000061035.4 Fer3 like bHLH transcription factor (from RefSeq NM_033522.2) ENSMUST00000061035.1 ENSMUST00000061035.2 ENSMUST00000061035.3 FER3L_MOUSE NM_033522 Nato Ntwist Q923Z4 uc007niv.1 uc007niv.2 uc007niv.3 Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins. Heterodimer with TCF3/E12. Interacts with the bHLH domain of TCF3/E12. Nucleus Detected in the developing central nervous system, in particular in embryonic ventral neural tube, brain, and spinal cord. Detected in embryonic intestine. Detected in embryonic and adult thalamus, hypothalamus, midbrain, pons and medulla. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus floor plate development negative regulation of transcription, DNA-templated protein dimerization activity cell development regulation of neurogenesis uc007niv.1 uc007niv.2 uc007niv.3 
ENSMUST00000061038.4 Sprr2b ENSMUST00000061038.4 small proline-rich protein 2B (from RefSeq NM_011469.4) A9JTY7 A9JTY7_MOUSE ENSMUST00000061038.1 ENSMUST00000061038.2 ENSMUST00000061038.3 NM_011469 Sprr2b uc008qdr.1 uc008qdr.2 uc008qdr.3 Belongs to the cornifin (SPRR) family. cornified envelope uc008qdr.1 uc008qdr.2 uc008qdr.3 
ENSMUST00000061045.3 Sntn ENSMUST00000061045.3 sentan, cilia apical structure protein (from RefSeq NM_177624.3) B7FF66 ENSMUST00000061045.1 ENSMUST00000061045.2 NM_177624 Q8C9X1 S100a1l SNTAN_MOUSE uc007sgc.1 uc007sgc.2 May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules. Cell projection, cilium Note=Expressed exclusively at the cilium tip where it localizes between the cell membrane and peripheral A- subfibers. Expressed exclusively in ciliated epithelial cells. Detected in ciliated epithelium of trachea and oviduct (at protein level). Expression gradually increases during in vitro ciliogenesis. 'Sentan' means 'tip' in Japanese. Belongs to the S-100 family. molecular_function cellular_component cilium biological_process cell projection transition metal ion binding uc007sgc.1 uc007sgc.2 
ENSMUST00000061047.7 Phlpp1 ENSMUST00000061047.7 PH domain and leucine rich repeat protein phosphatase 1 (from RefSeq NM_133821.3) ENSMUST00000061047.1 ENSMUST00000061047.2 ENSMUST00000061047.3 ENSMUST00000061047.4 ENSMUST00000061047.5 ENSMUST00000061047.6 Kiaa0606 NM_133821 PHLP1_MOUSE Phlpp Plekhe1 Q6PCN0 Q8CHE4 Q8QZU8 Q8R5E5 Q99KL6 Scop uc007cgv.1 uc007cgv.2 uc007cgv.3 uc007cgv.4 Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (By similarity). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylates RAF1 inhibiting its kinase activity. May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (PubMed:17382888). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (PubMed:20080691). Involved in development and function of regulatory T-cells (PubMed:21498666). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; Insensitive to okadaic acid. Deubiquitination by WDR48-USP12 complex positively regulates PHLPP1 stability. Interacts with the nucleotide free form of K-Ras (KRAS) via its LRR repeats (By similarity). Interacts with AKT2, AKT3 and PRKCB. Interacts with WDR48 and USP12 (By similarity). Cytoplasm. Membrane; Peripheral membrane protein. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=beta; IsoId=Q8CHE4-1; Sequence=Displayed; Name=2; Synonyms=alpha; IsoId=Q8CHE4-2; Sequence=VSP_057810; Isoforms 1 and 2 are expressed in the retina (PubMed:20089132). Up-regulated in the hippocampus upon chronic methamphetamine treatment. The PH domain is required for interaction with PRKCB and its dephosphorylation. Sequence=AAH59254.1; Type=Frameshift; Evidence=; regulation of protein phosphorylation regulation of T cell anergy catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity nucleus nucleoplasm cytoplasm plasma membrane protein dephosphorylation apoptotic process entrainment of circadian clock membrane hydrolase activity nuclear membrane regulation of apoptotic process regulation of MAPK cascade regulation of JNK cascade metal ion binding positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade positive regulation of protein kinase C signaling negative regulation of protein kinase C signaling regulation of p38MAPK cascade uc007cgv.1 uc007cgv.2 uc007cgv.3 uc007cgv.4 
ENSMUST00000061070.6 Pwwp2a ENSMUST00000061070.6 PWWP domain containing 2A, transcript variant 2 (from RefSeq NM_027557.2) A2AJK9 A2AJL0 ENSMUST00000061070.1 ENSMUST00000061070.2 ENSMUST00000061070.3 ENSMUST00000061070.4 ENSMUST00000061070.5 Kiaa1935 NM_027557 PWP2A_MOUSE Q3TBG3 Q69Z61 Q9CUT9 uc007imu.1 uc007imu.2 uc007imu.3 uc007imu.4 uc007imu.5 Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin- modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:33235983). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (By similarity). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (PubMed:30228260, PubMed:33235983). Essential for proper mitosis progression (By similarity). Component of a MTA1-specific subcomplex of the NuRD complex (M1HR), which is composed of PWWP2A, MTA1/2, HDAC1/2, and RBBP4/7 but does not contain CHD4 and MBD3 (By similarity). Interacts with MTA1; the interaction mediates the association of PWWP2A with the M1HR complex (By similarity). Interacts with H2A.Z/H2AZ1 (By similarity). Interacts (via PWWP domain) with histone H3 trimethylated at 'Lys-36' (H3K36me3) (By similarity). Does not interact with CHD4 and MBD3 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69Z61-1; Sequence=Displayed; Name=2; IsoId=Q69Z61-2; Sequence=VSP_029549, VSP_029550, VSP_029551; Sequence=BAB29417.1; Type=Frameshift; Evidence=; Sequence=BAD32583.1; Type=Erroneous initiation; Evidence=; Sequence=CAM20715.1; Type=Erroneous gene model prediction; Evidence=; chromatin binding nucleus biological_process histone binding uc007imu.1 uc007imu.2 uc007imu.3 uc007imu.4 uc007imu.5 
ENSMUST00000061071.13 Plppr4 ENSMUST00000061071.13 phospholipid phosphatase related 4 (from RefSeq NM_177664.5) B2RQ15 D3Bwg0562e ENSMUST00000061071.1 ENSMUST00000061071.10 ENSMUST00000061071.11 ENSMUST00000061071.12 ENSMUST00000061071.2 ENSMUST00000061071.3 ENSMUST00000061071.4 ENSMUST00000061071.5 ENSMUST00000061071.6 ENSMUST00000061071.7 ENSMUST00000061071.8 ENSMUST00000061071.9 Kiaa0455 Lppr4 NM_177664 PLPR4_MOUSE Php1 Plppr4 Prg1 Q6ZQA8 Q7TME0 Q8BV73 Q8BXK2 Q8R3R6 uc008rcz.1 uc008rcz.2 uc008rcz.3 uc008rcz.4 uc008rcz.5 Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways (PubMed:19766573). Binds lysophosphatidic acid (LPA) and mediates its internalization into cells (PubMed:26671989). Could act as receptor or a transporter of this lipid at the post-synaptic membrane (PubMed:19766573, PubMed:26671989). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity). Postsynaptic density membrane ; Multi-pass membrane protein Brain-specific, it is exclusively expressed in neurons (at protein level). O-glycosylated. Probably at Ser-347. Knockout mice lacking Plppr4 are viable but show a severe alteration of synaptic transmission leading to juvenile epileptic seizures (PubMed:19766573). Excitatory transmission in CA1 pyramidal neurons is significantly increased (PubMed:19766573). It is associated with transiently reduced weight during development, a reduction in brain size and higher mortality 3 to 4 weeks after birth (PubMed:19766573). Heterozygous knockout mice, show loss of somatosensory filter function and altered resilience during stress- related behaviors (PubMed:26671989). Belongs to the PA-phosphatase related phosphoesterase family. Originally described as a 2-lysophosphatidate/LPA phosphatase (PubMed:12730698). However, following studies suggested it does not have such activity or only a residual one (PubMed:19766573). This is further supported by the fact that the phosphatase sequence motifs as well as the His residue acting as a nucleophile in active phosphatases of the PA-phosphatase related phosphoesterase family are not conserved (PubMed:19766573). Sequence=BAC37711.1; Type=Erroneous initiation; Evidence=; Sequence=BAC97959.1; Type=Erroneous initiation; Evidence=; protein binding integral component of plasma membrane phospholipid metabolic process axonogenesis phosphatidate phosphatase activity external side of plasma membrane membrane integral component of membrane hydrolase activity phosphatase activity lipid phosphatase activity phospholipid dephosphorylation inner ear development glutamatergic synapse integral component of postsynaptic density membrane uc008rcz.1 uc008rcz.2 uc008rcz.3 uc008rcz.4 uc008rcz.5 
ENSMUST00000061074.10 Vmn2r68 ENSMUST00000061074.10 vomeronasal 2, receptor 68 (from RefSeq NM_001105181.1) ENSMUST00000061074.1 ENSMUST00000061074.2 ENSMUST00000061074.3 ENSMUST00000061074.4 ENSMUST00000061074.5 ENSMUST00000061074.6 ENSMUST00000061074.7 ENSMUST00000061074.8 ENSMUST00000061074.9 L7N2B3 L7N2B3_MOUSE NM_001105181 Vmn2r68 uc012foi.1 uc012foi.2 uc012foi.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012foi.1 uc012foi.2 uc012foi.3 
ENSMUST00000061086.9 Ptprcap ENSMUST00000061086.9 protein tyrosine phosphatase receptor type C polypeptide-associated protein (from RefSeq NM_016933.3) ENSMUST00000061086.1 ENSMUST00000061086.2 ENSMUST00000061086.3 ENSMUST00000061086.4 ENSMUST00000061086.5 ENSMUST00000061086.6 ENSMUST00000061086.7 ENSMUST00000061086.8 NM_016933 PTCA_MOUSE Q64697 uc008fza.1 uc008fza.2 uc008fza.3 Interacts with CD45/PTPRC. Membrane ; Single-pass membrane protein Leukocyte-specific. Expressed in B- and T-cell lines, in spleen, thymus, and bone marrow of adult mice, and in embryos. Phosphorylated on tyrosine residues. Sequence=AAA67166.1; Type=Erroneous initiation; Evidence=; plasma membrane membrane integral component of membrane uc008fza.1 uc008fza.2 uc008fza.3 
ENSMUST00000061093.7 Slc30a10 ENSMUST00000061093.7 solute carrier family 30, member 10 (from RefSeq NM_001033286.2) ENSMUST00000061093.1 ENSMUST00000061093.2 ENSMUST00000061093.3 ENSMUST00000061093.4 ENSMUST00000061093.5 ENSMUST00000061093.6 NM_001033286 Q32NY2 Q3UVU3 Slc30a10 ZNT10_MOUSE uc007dzk.1 uc007dzk.2 uc007dzk.3 Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange. Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis (PubMed:28461334). Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (By similarity). Reaction=Ca(2+)(in) + Mn(2+)(out) = Ca(2+)(out) + Mn(2+)(in); Xref=Rhea:RHEA:73059, ChEBI:CHEBI:29035, ChEBI:CHEBI:29108; Evidence=; Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence=; Forms homodimers. Forms heterodimers and high-molecular weight oligomers with SLC30A3, SLC30A2 and SLC30A4; heterodimerization is mediated by covalent-bound tyrosine residues, occurs probably in a tissue-specific manner and could mediate the intracellular zinc transport activity into early endosomes and recycling endosomes. Q3UVU3; Q2HJ10: Slc30a2; NbExp=2; IntAct=EBI-13945374, EBI-13945312; Cell membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Recycling endosome membrane Early endosome membrane ; Multi-pass membrane protein Note=Localization to the Golgi and plasma membrane is regulated by zinc. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UVU3-1; Sequence=Displayed; Name=2; IsoId=Q3UVU3-2; Sequence=VSP_029867; Specifically expressed in fetal liver and fetal brain. Homozygous knockout mice lacking Slc30a10 are born at expected Mendelian ratios and do not display overt phenotype until postnatal day 16 to 18 (PubMed:28461334). After weaning they fail to gain weight, are smaller, and die prematurely (PubMed:28461334). Manganese levels are elevated in the tested tissues including brain, liver, blood and thyroid and manganese toxicity induces an hypothyroidism phenotype (PubMed:28461334). Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. protein binding endosome early endosome Golgi apparatus plasma membrane ion transport cation transport manganese ion transport zinc II ion transport epidermal growth factor receptor signaling pathway cation transmembrane transporter activity membrane integral component of membrane negative regulation of neuron apoptotic process recycling endosome transmembrane transport positive regulation of ERK1 and ERK2 cascade manganese ion transmembrane transport regulation of zinc ion transport negative regulation of reactive oxygen species biosynthetic process cellular response to angiotensin negative regulation of cellular senescence uc007dzk.1 uc007dzk.2 uc007dzk.3 
ENSMUST00000061096.7 Or51f23 ENSMUST00000061096.7 olfactory receptor family 51 subfamily F member 23 (from RefSeq NM_146359.2) E9PWA8 E9PWA8_MOUSE ENSMUST00000061096.1 ENSMUST00000061096.2 ENSMUST00000061096.3 ENSMUST00000061096.4 ENSMUST00000061096.5 ENSMUST00000061096.6 NM_146359 Olfr564 Or51f23 uc009iso.1 uc009iso.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on protein homology data. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009iso.1 uc009iso.2 
ENSMUST00000061099.14 Ccdc169 ENSMUST00000061099.14 coiled-coil domain containing 169, transcript variant 1 (from RefSeq NM_177203.3) CC169_MOUSE ENSMUST00000061099.1 ENSMUST00000061099.10 ENSMUST00000061099.11 ENSMUST00000061099.12 ENSMUST00000061099.13 ENSMUST00000061099.2 ENSMUST00000061099.3 ENSMUST00000061099.4 ENSMUST00000061099.5 ENSMUST00000061099.6 ENSMUST00000061099.7 ENSMUST00000061099.8 ENSMUST00000061099.9 NM_177203 Q8BVQ6 Q8BXX9 uc008pgg.1 uc008pgg.2 uc008pgg.3 uc008pgg.4 uc008pgg.5 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BXX9-1; Sequence=Displayed; Name=2; IsoId=Q8BXX9-2; Sequence=VSP_035638; Belongs to the CCDC169 family. molecular_function cellular_component biological_process uc008pgg.1 uc008pgg.2 uc008pgg.3 uc008pgg.4 uc008pgg.5 
ENSMUST00000061111.10 Marveld1 ENSMUST00000061111.10 MARVEL (membrane-associating) domain containing 1 (from RefSeq NM_183195.3) ENSMUST00000061111.1 ENSMUST00000061111.2 ENSMUST00000061111.3 ENSMUST00000061111.4 ENSMUST00000061111.5 ENSMUST00000061111.6 ENSMUST00000061111.7 ENSMUST00000061111.8 ENSMUST00000061111.9 MALD1_MOUSE NM_183195 Q7TQJ1 Q8BHQ3 uc008hni.1 uc008hni.2 uc008hni.3 uc008hni.4 Microtubule-associated protein that exhibits cell cycle- dependent localization and can inhibit cell proliferation and migration. Cell membrane ; Multi-pass membrane protein Nucleus Cytoplasm, cytoskeleton Note=Observed in the nucleus and at the perinuclear region during interphase, but localizes at the mitotic spindle and midbody at metaphase. A significant fraction of MARVELD1 translocates to the plasma membrane during anaphase or upon microtubule depolymerization. nucleus cytoplasm cytoskeleton plasma membrane cell cycle membrane integral component of membrane structural constituent of myelin sheath myelination uc008hni.1 uc008hni.2 uc008hni.3 uc008hni.4 
ENSMUST00000061118.11 Slc25a26 ENSMUST00000061118.11 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 (from RefSeq NM_026255.5) ENSMUST00000061118.1 ENSMUST00000061118.10 ENSMUST00000061118.2 ENSMUST00000061118.3 ENSMUST00000061118.4 ENSMUST00000061118.5 ENSMUST00000061118.6 ENSMUST00000061118.7 ENSMUST00000061118.8 ENSMUST00000061118.9 NM_026255 Q5U680 Q8JZT2 SAMC_MOUSE Samc Slc25a26 uc009czr.1 uc009czr.2 uc009czr.3 uc009czr.4 uc009czr.5 Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L- homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl- L-methionine, the predominant methyl-group donor for macromolecule methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a by-product of methylation reactions. Reaction=S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out); Xref=Rhea:RHEA:75479, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. S-adenosyl-L-methionine transmembrane transporter activity mitochondrion mitochondrial inner membrane S-adenosyl-L-methionine transport membrane integral component of membrane transmembrane transporter activity transmembrane transport S-adenosyl-L-methionine transmembrane transport uc009czr.1 uc009czr.2 uc009czr.3 uc009czr.4 uc009czr.5 
ENSMUST00000061135.8 Msantd3 ENSMUST00000061135.8 Myb/SANT-like DNA-binding domain containing 3, transcript variant 3 (from RefSeq NM_001145925.1) ENSMUST00000061135.1 ENSMUST00000061135.2 ENSMUST00000061135.3 ENSMUST00000061135.4 ENSMUST00000061135.5 ENSMUST00000061135.6 ENSMUST00000061135.7 MSD3_MOUSE NM_001145925 Q9CR78 Q9CYY5 uc008svg.1 uc008svg.2 uc008svg.3 uc008svg.4 Belongs to the MSANTD3 family. cellular_component biological_process identical protein binding uc008svg.1 uc008svg.2 uc008svg.3 uc008svg.4 
ENSMUST00000061143.15 Map7d1 ENSMUST00000061143.15 MAP7 domain containing 1, transcript variant 1 (from RefSeq NM_144941.3) A2AJI0 ENSMUST00000061143.1 ENSMUST00000061143.10 ENSMUST00000061143.11 ENSMUST00000061143.12 ENSMUST00000061143.13 ENSMUST00000061143.14 ENSMUST00000061143.2 ENSMUST00000061143.3 ENSMUST00000061143.4 ENSMUST00000061143.5 ENSMUST00000061143.6 ENSMUST00000061143.7 ENSMUST00000061143.8 ENSMUST00000061143.9 Kiaa1187 MA7D1_MOUSE Mtap7d1 NM_144941 Q80TI3 Q8CIL3 Q8VCG2 Q91YQ4 uc008usz.1 uc008usz.2 uc008usz.3 uc008usz.4 uc008usz.5 Cytoplasm, cytoskeleton, spindle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AJI0-1; Sequence=Displayed; Name=2; IsoId=A2AJI0-2; Sequence=VSP_028489; Belongs to the MAP7 family. Sequence=AAH16081.1; Type=Erroneous initiation; Evidence=; Sequence=AAH19977.1; Type=Erroneous initiation; Evidence=; Sequence=BAC65744.3; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it is derived from pre-RNA.; Evidence=; microtubule cytoskeleton organization cytoplasm spindle cytosol cytoskeleton microtubule cytoskeleton uc008usz.1 uc008usz.2 uc008usz.3 uc008usz.4 uc008usz.5 
ENSMUST00000061156.10 Hacd2 ENSMUST00000061156.10 3-hydroxyacyl-CoA dehydratase 2 (from RefSeq NM_023587.2) ENSMUST00000061156.1 ENSMUST00000061156.2 ENSMUST00000061156.3 ENSMUST00000061156.4 ENSMUST00000061156.5 ENSMUST00000061156.6 ENSMUST00000061156.7 ENSMUST00000061156.8 ENSMUST00000061156.9 HACD2_MOUSE Hacd2 NM_023587 Ptplb Q3UG38 Q9D3B1 Q9JLK1 uc007zbi.1 uc007zbi.2 uc007zbi.3 Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Reaction=a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O; Xref=Rhea:RHEA:45812, ChEBI:CHEBI:15377, ChEBI:CHEBI:83728, ChEBI:CHEBI:85440; EC=4.2.1.134; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45813; Evidence=; Reaction=(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O; Xref=Rhea:RHEA:39159, ChEBI:CHEBI:15377, ChEBI:CHEBI:61526, ChEBI:CHEBI:74278; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39160; Evidence=; Reaction=(3R)-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O; Xref=Rhea:RHEA:39155, ChEBI:CHEBI:15377, ChEBI:CHEBI:71412, ChEBI:CHEBI:76374; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39156; Evidence=; Reaction=(3R)-hydroxyeicosanoyl-CoA = (2E)-eicosenoyl-CoA + H2O; Xref=Rhea:RHEA:39175, ChEBI:CHEBI:15377, ChEBI:CHEBI:74691, ChEBI:CHEBI:76373; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39176; Evidence=; Reaction=(3R)-hydroxydocosanoyl-CoA = (2E)-docosenoyl-CoA + H2O; Xref=Rhea:RHEA:39187, ChEBI:CHEBI:15377, ChEBI:CHEBI:74692, ChEBI:CHEBI:76375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39188; Evidence=; Reaction=(3R)-hydroxytetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O; Xref=Rhea:RHEA:39199, ChEBI:CHEBI:15377, ChEBI:CHEBI:74693, ChEBI:CHEBI:76377; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39200; Evidence=; Reaction=(3R)-hydroxyhexacosanoyl-CoA = (2E)-hexacosenoyl-CoA + H2O; Xref=Rhea:RHEA:39211, ChEBI:CHEBI:15377, ChEBI:CHEBI:74281, ChEBI:CHEBI:76378; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39212; Evidence=; Lipid metabolism; fatty acid biosynthesis. May interact with enzymes of the ELO family (including ELOVL1); with those enzymes that mediate condensation, the first of the four steps of the reaction cycle responsible for fatty acids elongation, may be part of a larger fatty acids elongase complex. Interacts with BCAP31. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the very long-chain fatty acids dehydratase HACD family. Shares some similarity with tyrosine phosphatase proteins but it has probably no phosphatase activity. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process membrane integral component of membrane lyase activity 3-hydroxyacyl-CoA dehydratase activity enzyme binding sphingolipid biosynthetic process integral component of endoplasmic reticulum membrane fatty acid elongation very long-chain fatty acid biosynthetic process 3-hydroxy-behenoyl-CoA dehydratase activity 3-hydroxy-lignoceroyl-CoA dehydratase activity uc007zbi.1 uc007zbi.2 uc007zbi.3 
ENSMUST00000061158.5 Commd3 ENSMUST00000061158.5 COMM domain containing 3 (from RefSeq NM_147778.4) A2ASR4 Bup COMD3_MOUSE ENSMUST00000061158.1 ENSMUST00000061158.2 ENSMUST00000061158.3 ENSMUST00000061158.4 NM_147778 Q3UKI1 Q63829 Q8C9P5 uc289tjc.1 uc289tjc.2 May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits. Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4A, CUL4B, CUL5. Cytoplasm Nucleus molecular_function cellular_component nucleus cytoplasm ion transport sodium ion transport biological_process uc289tjc.1 uc289tjc.2 
ENSMUST00000061169.7 Gal3st3 ENSMUST00000061169.7 galactose-3-O-sulfotransferase 3 (from RefSeq NM_001024717.2) ENSMUST00000061169.1 ENSMUST00000061169.2 ENSMUST00000061169.3 ENSMUST00000061169.4 ENSMUST00000061169.5 ENSMUST00000061169.6 G3ST3_MOUSE NM_001024717 P61315 uc008gco.1 uc008gco.2 uc008gco.3 uc008gco.4 Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc (By similarity). Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Protein modification; carbohydrate sulfation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Belongs to the galactose-3-O-sulfotransferase family. galactosylceramide sulfotransferase activity cellular_component Golgi apparatus glycolipid biosynthetic process membrane integral component of membrane transferase activity Golgi cisterna membrane galactose 3-O-sulfotransferase activity uc008gco.1 uc008gco.2 uc008gco.3 uc008gco.4 
ENSMUST00000061174.7 Sarm1 ENSMUST00000061174.7 sterile alpha and HEAT/Armadillo motif containing 1, transcript variant 2 (from RefSeq NM_172795.3) ENSMUST00000061174.1 ENSMUST00000061174.2 ENSMUST00000061174.3 ENSMUST00000061174.4 ENSMUST00000061174.5 ENSMUST00000061174.6 Kiaa0524 NM_172795 Q5SYG5 Q5SYG6 Q6A054 Q6PDS3 Q6SZW0 Q8BRI9 SARM1_MOUSE Sarm1 uc007kji.1 uc007kji.2 uc007kji.3 uc007kji.4 NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25818290, PubMed:26686637, PubMed:27735788, PubMed:32312889). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:21555464, PubMed:22678360, PubMed:25818290, PubMed:26686637, PubMed:26423149). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D- ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:28334607). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (By similarity). Can activate neuronal cell death in response to stress (PubMed:19587044). Regulates dendritic arborization through the MAPK4-JNK pathway (PubMed:17724133, PubMed:21555464). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:21555464). Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302; Evidence=; Reaction=NAD(+) = cyclic ADP-beta-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:38611, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:73672; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38612; Evidence=; Reaction=H2O + NADP(+) = ADP-D-ribose 2'-phosphate + H(+) + nicotinamide; Xref=Rhea:RHEA:19849, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:58349, ChEBI:CHEBI:58673; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19850; Evidence=; Autoinhibited: in the inactive state, the enzymatic TIR domain is held apart by the autoinhibiting ARM repeats. NAD(+)-binding to ARM repeats maintains an inactive state by promoting interaction between ARM repeats and the TIR domain, thereby facilitating inhibition of the enzymatic TIR domain. Following activation, possibly by nicotinamide mononucleotide (NMN), auto- inhibitory interactions are released, allowing self-association of the TIR domains and subsequent activation of the NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is facilitated by the octamer of SAM domains. Homooctamer; forms an octameric ring via SAM domains (By similarity). Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function (By similarity). Interacts with SDC2 (via cytoplasmic domain) and MAPK10/JNK3 (PubMed:17724133, PubMed:21555464). Q6PDS3; Q96A33: CCDC47; Xeno; NbExp=2; IntAct=EBI-6117196, EBI-720151; Q6PDS3; Q9H3K2: GHITM; Xeno; NbExp=2; IntAct=EBI-6117196, EBI-2868909; Q6PDS3; O43187: IRAK2; Xeno; NbExp=2; IntAct=EBI-6117196, EBI-447733; Q6PDS3; Q86UT6: NLRX1; Xeno; NbExp=2; IntAct=EBI-6117196, EBI-3893071; Q6PDS3; P46977: STT3A; Xeno; NbExp=2; IntAct=EBI-6117196, EBI-719212; Cytoplasm Cell projection, axon Cell projection, dendrite Synapse Mitochondrion Note=Associated with microtubules. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6PDS3-1; Sequence=Displayed; Name=2; IsoId=Q6PDS3-2; Sequence=VSP_013604; Name=3; IsoId=Q6PDS3-3; Sequence=VSP_013605; Name=4; IsoId=Q6PDS3-4; Sequence=VSP_013606, VSP_013607; Widely expressed in the brain and neurons (at protein level) (PubMed:21555464). Expressed in photoreceptor cells of the neural retina (PubMed:32312889). Down-regulated in sciatic nerve of mice with diabetic peripheral neuropathy (at protein level). The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. The ARM repeats inhibit the NAD(+) hydrolase (NADase) activity by binding to NAD(+): NAD(+)-binding to ARM repeats facilitates inhibition of the TIR domain NADase through their domain interface. In contrast to classical ARM repeats, the last helix of ARM 6 does not fold back to interact with the first two helices, but instead turns towards the N-terminus of SARM1. As a result, the two following motifs ARM 7 and ARM 8 reverse their directions and lie perpendicularly. Moreover, ARM repeats interact with different domains not only within each protomer but also of the adjacent ones. Phosphorylation at Ser-548 by JNK kinases (MAPK8, MAPK9 and /or MAPK10) enhance the NAD(+) hydrolase (NADase) activity. Phosphorylation at Ser-548 and subsequent activation takes place in response to oxidative stress conditions and inhibits mitochondrial respiration. Absence of Sarm1 provides a level of protection against axon degeneration (PubMed:22678360, PubMed:26912636, PubMed:28978465). Genetic deletion blocks Wallerian degeneration of sciatic nerve and cultured superior cervical ganglia and peripheral polyneuropathy induced by vincristine (PubMed:22678360, PubMed:27797810). Severed Sarm1 null axons are able to persist up to 72 hours after axotomy, whereas wild-type axons degenerate within 8 hours (PubMed:22678360). Similarly, axons appear to be protected from degeneration in a sciatic nerve lesion model, lasting up to 14 days compared with 3 days for wild type (PubMed:22678360). Mice display improved traumatic brain injury-associated phenotypes after injury: mice develop fewer beta-amyloid precursor protein aggregates in axons of the corpus callosum after traumatic brain injury and show improved axonal integrity (PubMed:26912636). Mice show some protection against early but not late axonal degeneration in experimental allergic encephalomyelitis mouse model (PubMed:32584865). Mice exhibit normal glucose metabolism and pain sensitivity but show attenuated diabetic peripheral neuropathy (PubMed:31439642). Mice lacking both Sarm1 and Nmnat2 are viable and survive: Sarm1 deficiency corrects axon outgrowth in mice lacking Nmnat2, independently of NMNAT metabolites, preventing perinatal lethality (PubMed:25818290). Mice lacking both Rho and Sarm1 show a level of protection against retinal degeneration induced by the absence of Rho: the absence of Sarm1 promoting rod and cone photoreceptor cell survival (PubMed:32312889). Belongs to the SARM1 family. Sequence=BAD32242.1; Type=Erroneous initiation; Evidence=; Sequence=CAI25546.1; Type=Erroneous gene model prediction; Evidence=; immune system process protein binding cytoplasm mitochondrion microtubule signal transduction nervous system development response to glucose positive regulation of signal transduction microtubule cytoskeleton cell junction cell differentiation axon dendrite extrinsic component of mitochondrial outer membrane negative regulation of MyD88-independent toll-like receptor signaling pathway signaling adaptor activity regulation of apoptotic process cell projection innate immune response synapse response to axon injury regulation of dendrite morphogenesis regulation of neuron death uc007kji.1 uc007kji.2 uc007kji.3 uc007kji.4 
ENSMUST00000061179.12 Rabgap1 ENSMUST00000061179.12 RAB GTPase activating protein 1, transcript variant 6 (from RefSeq NR_156419.1) B2RRC5 B2RRC5_MOUSE ENSMUST00000061179.1 ENSMUST00000061179.10 ENSMUST00000061179.11 ENSMUST00000061179.2 ENSMUST00000061179.3 ENSMUST00000061179.4 ENSMUST00000061179.5 ENSMUST00000061179.6 ENSMUST00000061179.7 ENSMUST00000061179.8 ENSMUST00000061179.9 NR_156419 Rabgap1 uc008jmx.1 uc008jmx.2 GTPase activator activity cytosol Rab GTPase binding regulation of GTPase activity positive regulation of GTPase activity uc008jmx.1 uc008jmx.2 
ENSMUST00000061185.8 Krt81 ENSMUST00000061185.8 keratin 81 (from RefSeq NM_001166157.1) E9QLY5 ENSMUST00000061185.1 ENSMUST00000061185.2 ENSMUST00000061185.3 ENSMUST00000061185.4 ENSMUST00000061185.5 ENSMUST00000061185.6 ENSMUST00000061185.7 KRT81_MOUSE Krt2-19 Krt81 NM_001166157 Q9ERE2 uc007xth.1 uc007xth.2 uc007xth.3 uc007xth.4 Heterotetramer of two type I and two type II keratins. Expressed in dorsal skin. There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). Belongs to the intermediate filament family. molecular_function intermediate filament biological_process keratin filament uc007xth.1 uc007xth.2 uc007xth.3 uc007xth.4 
ENSMUST00000061187.4 Dmrta2 ENSMUST00000061187.4 doublesex and mab-3 related transcription factor like family A2 (from RefSeq NM_172296.2) A2A9A2 DMTA2_MOUSE Dmrt5 ENSMUST00000061187.1 ENSMUST00000061187.2 ENSMUST00000061187.3 NM_172296 Q8CFF8 uc008ucv.1 uc008ucv.2 uc008ucv.3 May be involved in sexual development. Nucleus Expressed in adult brain and testis, as well as in embryonic ovary, kidney, heart, lung, stomach and brain. Expressed from 12.5 dpc to 15.5 dpc in ovary and from 12.5 dpc to 14.5 dpc in testis, but to a lower extent. Expression is detectable in early embryos at 8.5 dpc and in brain of embryos at 13.5 dpc. Belongs to the DMRT family. positive regulation of neuroblast proliferation DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated cerebral cortex regionalization skeletal muscle cell differentiation protein homodimerization activity sequence-specific DNA binding metal ion binding protein heterodimerization activity neuron fate specification dopaminergic neuron differentiation uc008ucv.1 uc008ucv.2 uc008ucv.3 
ENSMUST00000061190.8 Gp5 ENSMUST00000061190.8 glycoprotein 5 platelet (from RefSeq NM_008148.4) ENSMUST00000061190.1 ENSMUST00000061190.2 ENSMUST00000061190.3 ENSMUST00000061190.4 ENSMUST00000061190.5 ENSMUST00000061190.6 ENSMUST00000061190.7 Gp5 NM_008148 Q9QZU3 Q9QZU3_MOUSE uc007ywo.1 uc007ywo.2 uc007ywo.3 uc007ywo.4 membrane integral component of membrane uc007ywo.1 uc007ywo.2 uc007ywo.3 uc007ywo.4 
ENSMUST00000061193.4 Catsperg2 ENSMUST00000061193.4 cation channel sperm associated auxiliary subunit gamma 2 (from RefSeq NM_029714.4) C6KI89 CTSG2_MOUSE Catsperg Catsperg2 ENSMUST00000061193.1 ENSMUST00000061193.2 ENSMUST00000061193.3 NM_029714 uc012fhg.1 uc012fhg.2 Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation (PubMed:34225353, PubMed:19516020). Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (PubMed:19516020). Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG2, CATSPERD, CATSPERE, CATSPERZ, C2CD6/CATSPERT, SLCO6C1, TMEM249, TMEM262 and EFCAB9 (PubMed:34225353, PubMed:21224844, PubMed:19516020). HSPA1 may be an additional auxiliary complex member (PubMed:19516020). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (PubMed:34225353). The auxiliary CATSPERB, CATSPERG2, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively (PubMed:34225353). SLCO6C1 interacts with CATSPERE and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex (PubMed:34225353). C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane (Probable). Cell projection, cilium, flagellum membrane ; Single-pass type I membrane protein Testis-specific. Specifically expressed in the principal piece of the sperm tail (at protein level). Expressed in spermatocytes and spermatids within the seminiferous tubule but not in interstitial cells. Catsperg2 is absent in sperm from mice lacking Catsper1, suggesting that stable expression requires Catsper1. Belongs to the CATSPERG family. protein binding multicellular organism development spermatogenesis biological_process membrane integral component of membrane cell differentiation motile cilium CatSper complex sperm principal piece uc012fhg.1 uc012fhg.2 
ENSMUST00000061209.7 Ccdc71 ENSMUST00000061209.7 coiled-coil domain containing 71, transcript variant 2 (from RefSeq NM_133744.5) CCD71_MOUSE ENSMUST00000061209.1 ENSMUST00000061209.2 ENSMUST00000061209.3 ENSMUST00000061209.4 ENSMUST00000061209.5 ENSMUST00000061209.6 NM_133744 Q3UDX1 Q8VEG0 uc009rpq.1 uc009rpq.2 uc009rpq.3 uc009rpq.4 molecular_function cellular_component uc009rpq.1 uc009rpq.2 uc009rpq.3 uc009rpq.4 
ENSMUST00000061222.9 Kbtbd7 ENSMUST00000061222.9 kelch repeat and BTB (POZ) domain containing 7 (from RefSeq NM_001024135.2) ENSMUST00000061222.1 ENSMUST00000061222.2 ENSMUST00000061222.3 ENSMUST00000061222.4 ENSMUST00000061222.5 ENSMUST00000061222.6 ENSMUST00000061222.7 ENSMUST00000061222.8 G5E8C2 G5E8C2_MOUSE Kbtbd7 NM_001024135 uc007usy.1 uc007usy.2 uc007usy.3 uc007usy.4 uc007usy.1 uc007usy.2 uc007usy.3 uc007usy.4 
ENSMUST00000061234.14 Pdik1l ENSMUST00000061234.14 PDLIM1 interacting kinase 1 like, transcript variant 1 (from RefSeq NM_146156.3) A2A9L0 ENSMUST00000061234.1 ENSMUST00000061234.10 ENSMUST00000061234.11 ENSMUST00000061234.12 ENSMUST00000061234.13 ENSMUST00000061234.2 ENSMUST00000061234.3 ENSMUST00000061234.4 ENSMUST00000061234.5 ENSMUST00000061234.6 ENSMUST00000061234.7 ENSMUST00000061234.8 ENSMUST00000061234.9 NM_146156 PDK1L_MOUSE Q3URF0 Q8BKB3 Q8QZR7 uc008veq.1 uc008veq.2 uc008veq.3 uc008veq.4 uc008veq.5 uc008veq.6 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Nucleus Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleoplasm protein phosphorylation kinase activity phosphorylation transferase activity uc008veq.1 uc008veq.2 uc008veq.3 uc008veq.4 uc008veq.5 uc008veq.6 
ENSMUST00000061239.14 Sh3bp1 ENSMUST00000061239.14 SH3-domain binding protein 1, transcript variant 2 (from RefSeq NM_009164.4) A2A5V3 A2A5V3_MOUSE ENSMUST00000061239.1 ENSMUST00000061239.10 ENSMUST00000061239.11 ENSMUST00000061239.12 ENSMUST00000061239.13 ENSMUST00000061239.2 ENSMUST00000061239.3 ENSMUST00000061239.4 ENSMUST00000061239.5 ENSMUST00000061239.6 ENSMUST00000061239.7 ENSMUST00000061239.8 ENSMUST00000061239.9 NM_009164 Sh3bp1 uc007wro.1 uc007wro.2 uc007wro.3 uc007wro.4 GTPase activator activity cytoplasm signal transduction positive regulation of GTPase activity uc007wro.1 uc007wro.2 uc007wro.3 uc007wro.4 
ENSMUST00000061242.8 Arf1 ENSMUST00000061242.8 ADP-ribosylation factor 1, transcript variant 2 (from RefSeq NM_007476.4) ARF1_MOUSE ENSMUST00000061242.1 ENSMUST00000061242.2 ENSMUST00000061242.3 ENSMUST00000061242.4 ENSMUST00000061242.5 ENSMUST00000061242.6 ENSMUST00000061242.7 NM_007476 P10947 P32889 P84078 Q3THZ2 Q3U849 Q3UDG1 Q3UF76 uc007jdn.1 uc007jdn.2 uc007jdn.3 uc007jdn.4 Small GTPase involved in protein trafficking between different compartments (PubMed:11950392). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). The GTP- bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (PubMed:36566324). Plays also a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (PubMed:37392777). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Alternates between an inactive GDP-bound form and an active GTP-bound form (By similarity). Activated by guanine nucleotide-exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs) (By similarity). Interacts (when activated) with GGA1, GGA2 and GGA3; the interaction is required for proper subcellular location of GGA1, GGA2 and GGA3 (PubMed:11950392, PubMed:12679809). Interacts with ARHGAP21, ASAP2, HERC1, PRKCABP, PIP5K1B, TMED2, PSCD2, TMED10 and GRIA2 (PubMed:17347647). Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Interacts with PI4KB in the Golgi complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. Interacts with PLEKHA3. Interacts with PLEKHA8; the interaction, together with phosphatidylinositol 4-phosphate binding, is required for FAPP2-mediated glucosylceramide transfer activity. Interacts (activated) with PICK1 (via PDZ domain); the interaction blocks Arp2/3 complex inhibition. Interacts with IQSEC1 (By similarity). Interacts with C9orf72 (PubMed:27723745) (By similarity). P84078; Q5T5U3: ARHGAP21; Xeno; NbExp=3; IntAct=EBI-2308190, EBI-1642518; Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side Synapse, synaptosome Postsynaptic density Note=In the GDP-bound form, associates transiently with the membranes via its myristoylated N- terminus where guanine nucleotide-exchange factor (GEF)-mediated nucleotide exchange occurs (By similarity). Following nucleotide exchange, the GTP-bound form undergoes a conformational change, leading to the exposure of a myristoylated N-terminal amphipathic helix that provides stable membrane anchorage (By similarity). In intestine cells, ARF1 deletion results in a decreased number of proliferative cells as well as an increase in the number of apoptotic epithelial cells in the crypt areas. In addition, crypts from control mice survive and increase in size while isolated crypts from ARF1 knockout mice display an clear reduction in organoid- forming capacity (PubMed:37392777). Loss of ARF1 in bone marrow-derived mast cells attenuates mast cell expansion (PubMed:36566324). Belongs to the small GTPase superfamily. Arf family. Golgi membrane nucleotide binding magnesium ion binding regulation of receptor internalization protein binding GTP binding cytoplasm late endosome peroxisomal membrane Golgi apparatus trans-Golgi network cytosol plasma membrane cellular copper ion homeostasis intracellular protein transport actin filament organization endomembrane system postsynaptic density protein transport membrane vesicle-mediated transport GDP binding protein domain specific binding sarcomere cell junction COPI-coated vesicle cell leading edge macromolecular complex regulation of Arp2/3 complex-mediated actin nucleation very-low-density lipoprotein particle assembly protein homodimerization activity neuron projection positive regulation of catalytic activity synapse postsynaptic membrane positive regulation of endocytosis positive regulation of calcium ion-dependent exocytosis protein heterodimerization activity perinuclear region of cytoplasm positive regulation of protein secretion Golgi to transport vesicle transport long term synaptic depression positive regulation of dendritic spine development synaptic vesicle budding dendritic spine organization lysosomal membrane organization cellular response to virus postsynaptic actin cytoskeleton organization glutamatergic synapse positive regulation of sodium ion transmembrane transport positive regulation of late endosome to lysosome transport positive regulation of ER to Golgi vesicle-mediated transport regulation of phospholipid metabolic process mitotic cleavage furrow ingression phospholipase D activator activity uc007jdn.1 uc007jdn.2 uc007jdn.3 uc007jdn.4 
ENSMUST00000061260.8 Fat4 ENSMUST00000061260.8 FAT atypical cadherin 4 (from RefSeq NM_183221.4) E9QMR9 ENSMUST00000061260.1 ENSMUST00000061260.2 ENSMUST00000061260.3 ENSMUST00000061260.4 ENSMUST00000061260.5 ENSMUST00000061260.6 ENSMUST00000061260.7 FAT4_MOUSE Fatj NM_183221 Q2PZL6 Q68FE0 Q8BM82 Q8CD68 uc008pbf.1 uc008pbf.2 uc008pbf.3 Cadherins are cell-cell interaction molecules. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation. Heterophilic interaction with DCHS1; this interaction affects their respective protein levels. Interacts (via cytoplasmic domain) with MPDZ. Forms a complex with PALS1 and MPDZ. Membrane ; Single-pass type I membrane protein Note=In the kidney, localizes to primary cilia. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2PZL6-1; Sequence=Displayed; Name=2; IsoId=Q2PZL6-2; Sequence=VSP_032339, VSP_032340; Widely expressed. Expressed in all layers of the developing brain, with expression being most prominent at the ventricular margin. Deficient mice exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities. DCHS1 and FAT4 single mutants and DCHS1/FAT4 double mutants have similar phenotypes. Sequence=BAC27359.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC28751.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; branching involved in ureteric bud morphogenesis establishment of planar polarity kidney development heart morphogenesis calcium ion binding protein binding plasma membrane plasma membrane organization cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Notch signaling pathway fibroblast growth factor receptor signaling pathway membrane integral component of membrane cerebral cortex development neurogenesis hippo signaling ossification involved in bone maturation apical part of cell digestive tract development inner ear receptor stereocilium organization nephron development condensed mesenchymal cell proliferation regulation of metanephric nephron tubule epithelial cell differentiation cell-cell adhesion uc008pbf.1 uc008pbf.2 uc008pbf.3 
ENSMUST00000061262.11 Podxl2 ENSMUST00000061262.11 podocalyxin-like 2, transcript variant 10 (from RefSeq NM_001379223.1) ENSMUST00000061262.1 ENSMUST00000061262.10 ENSMUST00000061262.2 ENSMUST00000061262.3 ENSMUST00000061262.4 ENSMUST00000061262.5 ENSMUST00000061262.6 ENSMUST00000061262.7 ENSMUST00000061262.8 ENSMUST00000061262.9 G3X9D3 G3X9D3_MOUSE NM_001379223 Podxl2 uc291gvl.1 uc291gvl.2 Membrane ; Single- pass type I membrane protein membrane integral component of membrane uc291gvl.1 uc291gvl.2 
ENSMUST00000061274.9 Gpr156 ENSMUST00000061274.9 G protein-coupled receptor 156 (from RefSeq NM_153394.2) A0A0R4J0P3 A0A0R4J0P3_MOUSE ENSMUST00000061274.1 ENSMUST00000061274.2 ENSMUST00000061274.3 ENSMUST00000061274.4 ENSMUST00000061274.5 ENSMUST00000061274.6 ENSMUST00000061274.7 ENSMUST00000061274.8 Gpr156 NM_153394 uc007zel.1 uc007zel.2 uc007zel.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. G-protein coupled receptor activity G-protein coupled GABA receptor activity plasma membrane G-protein coupled receptor signaling pathway membrane integral component of membrane uc007zel.1 uc007zel.2 uc007zel.3 
ENSMUST00000061279.10 Pcdhga11 ENSMUST00000061279.10 protocadherin gamma subfamily A, 11 (from RefSeq NM_033594.2) ENSMUST00000061279.1 ENSMUST00000061279.2 ENSMUST00000061279.3 ENSMUST00000061279.4 ENSMUST00000061279.5 ENSMUST00000061279.6 ENSMUST00000061279.7 ENSMUST00000061279.8 ENSMUST00000061279.9 NM_033594 Pcdhga11 Q91XY8 Q91XY8_MOUSE uc008erb.1 uc008erb.2 uc008erb.3 uc008erb.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008erb.1 uc008erb.2 uc008erb.3 uc008erb.4 
ENSMUST00000061280.17 Pcmtd1 ENSMUST00000061280.17 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 (from RefSeq NM_183028.3) ENSMUST00000061280.1 ENSMUST00000061280.10 ENSMUST00000061280.11 ENSMUST00000061280.12 ENSMUST00000061280.13 ENSMUST00000061280.14 ENSMUST00000061280.15 ENSMUST00000061280.16 ENSMUST00000061280.2 ENSMUST00000061280.3 ENSMUST00000061280.4 ENSMUST00000061280.5 ENSMUST00000061280.6 ENSMUST00000061280.7 ENSMUST00000061280.8 ENSMUST00000061280.9 NM_183028 Pcmtd1 Q3TGS5 Q3TGS5_MOUSE uc007agb.1 uc007agb.2 Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family. protein-L-isoaspartate (D-aspartate) O-methyltransferase activity cellular protein modification process protein methylation methyltransferase activity transferase activity methylation uc007agb.1 uc007agb.2 
ENSMUST00000061283.15 Crlf3 ENSMUST00000061283.15 cytokine receptor-like factor 3, transcript variant 1 (from RefSeq NM_018776.2) CRLF3_MOUSE Creme9 Cytor4 ENSMUST00000061283.1 ENSMUST00000061283.10 ENSMUST00000061283.11 ENSMUST00000061283.12 ENSMUST00000061283.13 ENSMUST00000061283.14 ENSMUST00000061283.2 ENSMUST00000061283.3 ENSMUST00000061283.4 ENSMUST00000061283.5 ENSMUST00000061283.6 ENSMUST00000061283.7 ENSMUST00000061283.8 ENSMUST00000061283.9 NM_018776 Q5SYK6 Q91W21 Q9R262 Q9Z2L7 uc007kld.1 uc007kld.2 uc007kld.3 This gene encodes a cytokine receptor-like factor that contains a fibronectin type 3 domain. The encoded protein may act as a negative regulator of the cell cycle. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. May play a role in the negative regulation of cell cycle progression. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z2L7-1; Sequence=Displayed; Name=2; IsoId=Q9Z2L7-2; Sequence=VSP_025847, VSP_025848; Belongs to the cytokine receptor-like factor 3 family. Sequence=CAI24764.1; Type=Erroneous gene model prediction; Evidence=; G1/S transition of mitotic cell cycle DNA binding nucleus cytoplasm cytosol plasma membrane negative regulation of cell growth identical protein binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade positive regulation of cell cycle arrest uc007kld.1 uc007kld.2 uc007kld.3 
ENSMUST00000061287.12 Cep112 ENSMUST00000061287.12 centrosomal protein 112, transcript variant 2 (from RefSeq NM_029606.3) CE112_MOUSE Ccdc46 ENSMUST00000061287.1 ENSMUST00000061287.10 ENSMUST00000061287.11 ENSMUST00000061287.2 ENSMUST00000061287.3 ENSMUST00000061287.4 ENSMUST00000061287.5 ENSMUST00000061287.6 ENSMUST00000061287.7 ENSMUST00000061287.8 ENSMUST00000061287.9 NM_029606 Q5PR68 Q80ZN6 Q99JS4 Q9D9T1 uc007mbr.1 uc007mbr.2 uc007mbr.3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes around spindle poles in some cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5PR68-1; Sequence=Displayed; Name=2; IsoId=Q5PR68-2; Sequence=VSP_018340, VSP_018341; Sequence=AAH86808.1; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton plasma membrane inhibitory synapse receptor localization to synapse uc007mbr.1 uc007mbr.2 uc007mbr.3 
ENSMUST00000061294.5 Crh ENSMUST00000061294.5 corticotropin releasing hormone (from RefSeq NM_205769.3) CRF_MOUSE ENSMUST00000061294.1 ENSMUST00000061294.2 ENSMUST00000061294.3 ENSMUST00000061294.4 Gm1347 NM_205769 Q14AA2 Q8CIT0 uc008orx.1 uc008orx.2 uc008orx.3 This gene encodes a member of the corticotropin-releasing factor family and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is a neuropeptide hormone that binds to the corticotropin releasing hormone receptors (CRHR1 and CRHR2) to stimulate the release of adrenocorticotropic hormone from the pituitary gland in response to stress. The encoded protein may also regulate angiogenesis and inflammation. Homozygous knockout mice for this gene exhibit reduced corticosterone levels while the offspring of these mice die perinatally. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FO714297.1, CJ050024.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (PubMed:23470617). Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain). Secreted Expressed in parvocellular paraventricular nucleus of the hypothalamus and in medial accessory olivary nucleus. Up-regulated during water-avoidance stress. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. positive regulation of protein phosphorylation synaptic transmission, dopaminergic negative regulation of systemic arterial blood pressure hormone activity extracellular region extracellular space cytoplasm glucocorticoid biosynthetic process inflammatory response female pregnancy learning or memory steroid metabolic process positive regulation of cell proliferation associative learning hormone-mediated apoptotic signaling pathway positive regulation of gene expression negative regulation of gene expression negative regulation of norepinephrine secretion positive regulation of cell death regulation of serotonin secretion diterpenoid metabolic process corticotropin-releasing hormone activity hypothalamus development lung development adrenal gland development negative regulation of epinephrine secretion negative regulation of luteinizing hormone secretion locomotory exploration behavior positive regulation of insulin secretion involved in cellular response to glucose stimulus response to immobilization stress response to cocaine response to drug neuronal cell body varicosity perikaryon response to estrogen positive regulation of cAMP-mediated signaling response to ethanol response to ether response to pain ion homeostasis response to corticosterone corticotropin-releasing hormone receptor 1 binding corticotropin-releasing hormone receptor 2 binding positive regulation of corticotropin secretion positive regulation of cortisol secretion long-term synaptic potentiation positive regulation of digestive system process negative regulation of cell death negative regulation of glucagon secretion cellular response to cocaine cellular response to dexamethasone stimulus positive regulation of calcium ion import regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of corticosterone secretion positive regulation of behavioral fear response uc008orx.1 uc008orx.2 uc008orx.3 
ENSMUST00000061295.7 Dnajc22 ENSMUST00000061295.7 DnaJ heat shock protein family (Hsp40) member C22, transcript variant 1 (from RefSeq NM_176835.3) DJC22_MOUSE ENSMUST00000061295.1 ENSMUST00000061295.2 ENSMUST00000061295.3 ENSMUST00000061295.4 ENSMUST00000061295.5 ENSMUST00000061295.6 NM_176835 Q8CHS2 uc007xou.1 uc007xou.2 uc007xou.3 uc007xou.4 May function as a co-chaperone. Membrane ; Multi-pass membrane protein cellular_component membrane integral component of membrane uc007xou.1 uc007xou.2 uc007xou.3 uc007xou.4 
ENSMUST00000061318.9 Adamts12 ENSMUST00000061318.9 ADAM metallopeptidase with thrombospondin type 1 motif 12 (from RefSeq NM_175501.3) ATS12_MOUSE E9QKD6 ENSMUST00000061318.1 ENSMUST00000061318.2 ENSMUST00000061318.3 ENSMUST00000061318.4 ENSMUST00000061318.5 ENSMUST00000061318.6 ENSMUST00000061318.7 ENSMUST00000061318.8 NM_175501 Q811B3 Q8BK92 Q8BKY1 uc007vhb.1 uc007vhb.2 uc007vhb.3 This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Mice lacking the encoded protein exhibit increased angiogenic response and tumor invasion in different models of angiogenesis and, severe inflammation and delayed recovery when subjected to experimental conditions that induce colitis, endotoxic sepsis and pancreatitis. [provided by RefSeq, Jul 2016]. ##Evidence-Data-START## Transcript exon combination :: AJ537452.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Metalloprotease that plays a role in the degradation of COMP (By similarity). Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Inhibited by alpha-2 macroglobulin. Interacts with COMP. Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q811B3-1; Sequence=Displayed; Name=2; IsoId=Q811B3-2; Sequence=VSP_013149, VSP_013150; The C-terminal four TSP1-like repeats are necessary and sufficient for binding COMP. The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Subjected to an intracellular maturation process yielding a 120 kDa N-terminal fragment containing the metalloproteinase, disintegrin, one TSP type-1 and the Cys-rich domains and a 83 kDa C-terminal fragment containing the spacer 2 and four TSP type-1 domains. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2- G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3- glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). metalloendopeptidase activity extracellular region proteolysis cell-matrix adhesion peptidase activity metallopeptidase activity cell migration hydrolase activity proteoglycan catabolic process negative regulation of chondrocyte differentiation metal ion binding regulation of inflammatory response proteolysis involved in cellular protein catabolic process cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to BMP stimulus regulation of endothelial tube morphogenesis negative regulation of hepatocyte growth factor receptor signaling pathway negative regulation of cellular response to vascular endothelial growth factor stimulus negative regulation of cellular response to hepatocyte growth factor stimulus uc007vhb.1 uc007vhb.2 uc007vhb.3 
ENSMUST00000061326.5 Uqcrq ENSMUST00000061326.5 ubiquinol-cytochrome c reductase, complex III subunit VII, transcript variant 1 (from RefSeq NM_025352.3) ENSMUST00000061326.1 ENSMUST00000061326.2 ENSMUST00000061326.3 ENSMUST00000061326.4 NM_025352 Q9CQ69 QCR8_MOUSE uc007ivy.1 uc007ivy.2 uc007ivy.3 uc007ivy.4 uc007ivy.5 Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:19026783). Interacts with UQCC6 (PubMed:32161263). Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the UQCRQ/QCR8 family. mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex III mitochondrial electron transport, ubiquinol to cytochrome c ubiquinol-cytochrome-c reductase activity membrane subthalamus development pons development cerebellar Purkinje cell layer development hippocampus development thalamus development hypothalamus development pyramidal neuron development midbrain development oxidation-reduction process respiratory chain uc007ivy.1 uc007ivy.2 uc007ivy.3 uc007ivy.4 uc007ivy.5 
ENSMUST00000061327.2 Fbxo48 ENSMUST00000061327.2 F-box protein 48, transcript variant 1 (from RefSeq NM_176982.2) ENSMUST00000061327.1 FBX48_MOUSE Fbx48 NM_176982 Q8C9J8 Q8CAT8 uc007ibu.1 uc007ibu.2 molecular_function cytoplasm SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process uc007ibu.1 uc007ibu.2 
ENSMUST00000061328.6 Sowahb ENSMUST00000061328.6 sosondowah ankyrin repeat domain family member B (from RefSeq NM_175270.5) Ankrd56 ENSMUST00000061328.1 ENSMUST00000061328.2 ENSMUST00000061328.3 ENSMUST00000061328.4 ENSMUST00000061328.5 NM_175270 Q8BZS7 Q8BZW2 SWAHB_MOUSE uc008ydw.1 uc008ydw.2 Belongs to the SOWAH family. molecular_function cellular_component biological_process uc008ydw.1 uc008ydw.2 
ENSMUST00000061334.10 Mars2 ENSMUST00000061334.10 methionine-tRNA synthetase 2 (mitochondrial) (from RefSeq NM_175439.3) ENSMUST00000061334.1 ENSMUST00000061334.2 ENSMUST00000061334.3 ENSMUST00000061334.4 ENSMUST00000061334.5 ENSMUST00000061334.6 ENSMUST00000061334.7 ENSMUST00000061334.8 ENSMUST00000061334.9 NM_175439 Q3T9W7 Q499X9 Q8BWR9 Q8BXY1 SYMM_MOUSE uc007baj.1 uc007baj.2 uc007baj.3 Reaction=ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L- methionyl-tRNA(Met); Xref=Rhea:RHEA:13481, Rhea:RHEA-COMP:9667, Rhea:RHEA-COMP:9698, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530, ChEBI:CHEBI:456215; EC=6.1.1.10; Mitochondrion matrix Belongs to the class-I aminoacyl-tRNA synthetase family. Sequence=BAC31393.1; Type=Erroneous initiation; Evidence=; nucleotide binding aminoacyl-tRNA ligase activity methionine-tRNA ligase activity ATP binding mitochondrion mitochondrial matrix translation tRNA aminoacylation for protein translation methionyl-tRNA aminoacylation ligase activity uc007baj.1 uc007baj.2 uc007baj.3 
ENSMUST00000061343.4 Prss48 ENSMUST00000061343.4 serine protease 48, transcript variant 2 (from RefSeq NM_001411413.1) ENSMUST00000061343.1 ENSMUST00000061343.2 ENSMUST00000061343.3 Esspl Gm1019 NM_001411413 PRS48_MOUSE Q14B25 Q7M755 uc008pqz.1 uc008pqz.2 Secreted Belongs to the peptidase S1 family. serine-type endopeptidase activity extracellular region extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc008pqz.1 uc008pqz.2 
ENSMUST00000061360.1 Phgr1 ENSMUST00000061360.1 Phgr1 (from geneSymbol) AK019007 uc331rgi.1 uc331rgi.1 
ENSMUST00000061372.7 Tspyl1 ENSMUST00000061372.7 testis-specific protein, Y-encoded-like 1 (from RefSeq NM_009433.3) ENSMUST00000061372.1 ENSMUST00000061372.2 ENSMUST00000061372.3 ENSMUST00000061372.4 ENSMUST00000061372.5 ENSMUST00000061372.6 NM_009433 O88852 Q3TKW0 TSYL1_MOUSE Tspyl uc007eut.1 uc007eut.2 uc007eut.3 uc007eut.4 Nucleus, nucleolus Highly expressed in testis, ovary, liver, spleen, brain, kidney, prostate, lung, and heart. Low expression in liver. Detected in embryo at 10.5 dpc. Ubiquitinated by the CRL2(APPBP2) complex, which recognizes the Arg-Xaa-Xaa-Gly sequence at the C-terminus, leading to its degradation. Belongs to the nucleosome assembly protein (NAP) family. nucleus nucleolus nucleosome assembly enzyme binding uc007eut.1 uc007eut.2 uc007eut.3 uc007eut.4 
ENSMUST00000061390.9 Fkrp ENSMUST00000061390.9 fukutin related protein, transcript variant 1 (from RefSeq NM_173430.2) ENSMUST00000061390.1 ENSMUST00000061390.2 ENSMUST00000061390.3 ENSMUST00000061390.4 ENSMUST00000061390.5 ENSMUST00000061390.6 ENSMUST00000061390.7 ENSMUST00000061390.8 FKRP_MOUSE Fkrp NM_173430 Q8BJR3 Q8CG64 uc009fic.1 uc009fic.2 uc009fic.3 Catalyzes the transfer of CDP-ribitol to ribitol 5-phosphate previously attached by FKTN/fukutin of to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4- (phosphate-6-)mannose), a carbohydrate structure present in alpha- dystroglycan (DAG1) (PubMed:26923585). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta- 1 (PubMed:26923585). Reaction=3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O- 6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol = 3-O-[Rib-ol-P-Rib- ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D- Man)]-Thr-[protein] + CMP + H(+); Xref=Rhea:RHEA:39867, Rhea:RHEA- COMP:15021, Rhea:RHEA-COMP:17480, ChEBI:CHEBI:15378, ChEBI:CHEBI:57608, ChEBI:CHEBI:60377, ChEBI:CHEBI:142403, ChEBI:CHEBI:177331; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39868; Evidence=; Protein modification; protein glycosylation. Homodimer; disulfide-linked (By similarity). Forms a complex composed of FKRP, FKTN/fukutin, and RXYLT1/TMEM5 (By similarity). Exists also as large multimeric protein complexes (By similarity). May interact with the dystrophin-glycoprotein complex (DGC) (PubMed:17452335). Golgi apparatus membrane ingle-pass type II membrane protein Secreted Cell membrane, sarcolemma Rough endoplasmic reticulum Cytoplasm Note=The N-terminal hydrophobic domain is cleaved after translocation to the Golgi apparatus and the protein is secreted (PubMed:19900540). Localization at the cell membrane may require the presence of dystroglycan (PubMed:17452335). At the Golgi apparatus localizes to the middle-to-trans-cisternae (PubMed:12471058, PubMed:17554798). Detected in rough endoplasmic reticulum in myocytes (By similarity). Expressed in the retina, specifically in the inner segments of the photoreceptors, the outer plexiform layers, inner nuclear layers, and ganglion cell layers (at protein level) (PubMed:29416295). Expressed at highest levels in brain, lung, heart, kidney and liver (PubMed:12471058). N-glycosylated. Embryonic lethality before 12.5 dpc. Belongs to the LicD transferase family. Sequence=BAC37963.1; Type=Erroneous initiation; Evidence=; Golgi membrane dystroglycan binding extracellular region extracellular space nucleus cytoplasm endoplasmic reticulum rough endoplasmic reticulum Golgi apparatus cytosol plasma membrane protein glycosylation glycoprotein biosynthetic process membrane integral component of membrane protein processing transferase activity protein O-linked mannosylation sarcolemma uc009fic.1 uc009fic.2 uc009fic.3 
ENSMUST00000061391.9 Ccdc89 ENSMUST00000061391.9 coiled-coil domain containing 89 (from RefSeq NM_027298.1) Boip CCD89_MOUSE Ccdc89 ENSMUST00000061391.1 ENSMUST00000061391.2 ENSMUST00000061391.3 ENSMUST00000061391.4 ENSMUST00000061391.5 ENSMUST00000061391.6 ENSMUST00000061391.7 ENSMUST00000061391.8 NM_027298 Q9DA73 uc012fox.1 uc012fox.2 uc012fox.3 Interacts with HEY1. Cytoplasm Nucleus Note=Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to HEY1. Expression is restricted to the adult testis, where localization is almost exclusive to round spermatids. Expressed in adults but not embryos. Belongs to the CCDC89 family. Sequence=BAB24410.1; Type=Frameshift; Evidence=; Sequence=BAB24410.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; protein binding nucleus cytoplasm biological_process uc012fox.1 uc012fox.2 uc012fox.3 
ENSMUST00000061403.6 Krtap5-4 ENSMUST00000061403.6 keratin associated protein 5-4 (from RefSeq NM_015809.2) ENSMUST00000061403.1 ENSMUST00000061403.2 ENSMUST00000061403.3 ENSMUST00000061403.4 ENSMUST00000061403.5 KRA54_MOUSE Krtap5-4 NM_015809 Q62220 uc009kms.1 uc009kms.2 uc009kms.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Expressed during the active phases of the hair cycle in the medulla and the inner root sheath of the forming hair. Also expressed in the upper layers of the epidermis of skin. Belongs to the KRTAP type 5 family. molecular_function cellular_component intermediate filament biological_process keratin filament uc009kms.1 uc009kms.2 uc009kms.3 
ENSMUST00000061405.6 Pcdhb21 ENSMUST00000061405.6 protocadherin beta 21 (from RefSeq NM_053146.3) ENSMUST00000061405.1 ENSMUST00000061405.2 ENSMUST00000061405.3 ENSMUST00000061405.4 ENSMUST00000061405.5 NM_053146 Pcdhb18 Pcdhb21 Q91V48 Q91V48_MOUSE uc289oty.1 uc289oty.2 molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc289oty.1 uc289oty.2 
ENSMUST00000061419.9 Myef2l ENSMUST00000061419.9 myelin expression factor 2 like (from RefSeq NR_045710.1) ENSMUST00000061419.1 ENSMUST00000061419.2 ENSMUST00000061419.3 ENSMUST00000061419.4 ENSMUST00000061419.5 ENSMUST00000061419.6 ENSMUST00000061419.7 ENSMUST00000061419.8 Kiaa1341 MYEF2_MOUSE Mef2 Myef2 NR_045710 Q60690 Q6P930 Q6ZPT3 Q8C854 Q8QZZ1 uc029ujm.1 uc029ujm.2 uc029ujm.3 Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA. Monomer. Nucleus. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8C854-4; Sequence=Displayed; Name=2; IsoId=Q8C854-3; Sequence=VSP_013455; Name=3; IsoId=Q8C854-1; Sequence=VSP_013457, VSP_013458, VSP_013459; Name=4; IsoId=Q8C854-2; Sequence=VSP_013456, VSP_013460, VSP_013461; Highly expressed in the brain. Sequence=AAH60946.1; Type=Erroneous initiation; Evidence=; Sequence=BAC98146.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding single-stranded DNA binding RNA binding mRNA binding nucleus cytoplasm post-mRNA release spliceosomal complex ribonucleoprotein complex regulation of mRNA stability involved in response to oxidative stress uc029ujm.1 uc029ujm.2 uc029ujm.3 
ENSMUST00000061421.4 Mettl21c ENSMUST00000061421.4 methyltransferase 21C, AARS1 lysine (from RefSeq NM_001013799.1) ENSMUST00000061421.1 ENSMUST00000061421.2 ENSMUST00000061421.3 MT21C_MOUSE NM_001013799 Q8BLU2 uc007avv.1 uc007avv.2 Protein-lysine N-methyltransferase using S-adenosyl-L- methionine as methyl donor. Mono-di and trimethylates 'Lys-943' of AARS1. Reaction=L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:51736, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13053, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51737; Evidence=; Reaction=N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54196, Rhea:RHEA-COMP:13053, Rhea:RHEA-COMP:13827, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54197; Evidence=; Reaction=N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54200, Rhea:RHEA-COMP:13826, Rhea:RHEA- COMP:13827, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961, ChEBI:CHEBI:61976; Evidence=; Interacts with members of the heat shock protein 70 families; these proteins may possibly be methylation substrates for the enzyme. Nucleus Cytoplasm Specifically expressed in skeletal muscle. Belongs to the methyltransferase superfamily. METTL21 family. Contradictory results have been reported with regards to its ability to methylate HSPA8 and VCP. One study found that METTL21C methylates HSPA8, whereas one other reported methylation of VCP, but the experimental evidence was in both cases rather limited (PubMed:31346037, PubMed:29719249). Indeed, a subsequent, third study fails to observe in vitro activity of METTL21C on either HSPA8 or VCP (By similarity). nucleus protein methylation skeletal muscle tissue development methyltransferase activity hormone-mediated apoptotic signaling pathway regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine methylation heat shock protein binding methylation macromolecular complex cellular response to dexamethasone stimulus uc007avv.1 uc007avv.2 
ENSMUST00000061425.3 Pnma1 ENSMUST00000061425.3 paraneoplastic antigen MA1 (from RefSeq NM_027438.3) ENSMUST00000061425.1 ENSMUST00000061425.2 Ma1 NM_027438 PNMA1_MOUSE Q3UVU2 Q8C1C8 Q9CYP2 uc007oel.1 uc007oel.2 Nucleus, nucleolus Predominantly expressed in testis. Very low levels in the brain, including in the piriform cortex, hippocampus and some subcortical nuclei. Belongs to the PNMA family. inflammatory response to antigenic stimulus molecular_function nucleus nucleolus cytoplasm uc007oel.1 uc007oel.2 
ENSMUST00000061427.10 Adamts3 ENSMUST00000061427.10 ADAM metallopeptidase with thrombospondin type 1 motif 3, transcript variant 2 (from RefSeq NM_001081401.2) Adamts3 ENSMUST00000061427.1 ENSMUST00000061427.2 ENSMUST00000061427.3 ENSMUST00000061427.4 ENSMUST00000061427.5 ENSMUST00000061427.6 ENSMUST00000061427.7 ENSMUST00000061427.8 ENSMUST00000061427.9 G3X9D2 G3X9D2_MOUSE NM_001081401 uc008yaq.1 uc008yaq.2 uc008yaq.3 uc008yaq.4 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix Lacks conserved residue(s) required for the propagation of feature annotation. in utero embryonic development endopeptidase activity metalloendopeptidase activity extracellular space proteolysis peptidase activity metallopeptidase activity vascular endothelial growth factor production protein processing collagen biosynthetic process positive regulation of vascular endothelial growth factor signaling pathway uc008yaq.1 uc008yaq.2 uc008yaq.3 uc008yaq.4 
ENSMUST00000061437.5 Adrm1 ENSMUST00000061437.5 adhesion regulating molecule 1 26S proteasome ubiquitin receptor (from RefSeq NM_019822.3) ADRM1_MOUSE ENSMUST00000061437.1 ENSMUST00000061437.2 ENSMUST00000061437.3 ENSMUST00000061437.4 Gp110 NM_019822 Q3UKZ8 Q8BPH8 Q922A7 Q9JKV1 uc008oin.1 uc008oin.2 uc008oin.3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:18497827). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:18497827). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:18497827). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497827). Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (By similarity). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (By similarity). Component of the 19S proteasome regulatory particle complex (By similarity). The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (By similarity). Interacts with the proteasomal scaffolding protein PSMD1 (PubMed:18497827). Interacts with deubiquitinase UCHL5; this interaction activates the auto-inhibited UCHL5 by deoligomerizing it (PubMed:18497827). Interacts with UBQLN2 and ubiquitin (PubMed:18497827). Q9JKV1; Q99460-1: PSMD1; Xeno; NbExp=2; IntAct=EBI-8762776, EBI-15703973; Cytoplasm Nucleus Present in all tissues examined (at protein level). The Pru (pleckstrin-like receptor for ubiquitin) domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of 'Lys-48'-linked diubiquitin allows UCHL5 access to the distal subunit. Not N-glycosylated. Not O-glycosylated. Ubiquitinated by UBE3C in response to proteotoxic stress. Belongs to the ADRM1 family. Although initially described as a cell membrane glycoprotein, ADRM1 is intracellular and non-glycosylated, and has probably no direct role in cell adhesion. proteasome complex ovarian follicle development protease binding protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane transcription elongation from RNA polymerase II promoter ubiquitin-dependent protein catabolic process spermatid development proteasome regulatory particle, lid subcomplex positive regulation of endopeptidase activity regulation of T cell differentiation in thymus follicle-stimulating hormone signaling pathway ubiquitin binding proteasome assembly oogenesis thymus development Sertoli cell development positive regulation of growth hormone receptor signaling pathway adipose tissue development endopeptidase activator activity proteasome binding seminiferous tubule development uc008oin.1 uc008oin.2 uc008oin.3 
ENSMUST00000061444.5 Mrps16 ENSMUST00000061444.5 mitochondrial ribosomal protein S16, transcript variant 1 (from RefSeq NM_025440.3) ENSMUST00000061444.1 ENSMUST00000061444.2 ENSMUST00000061444.3 ENSMUST00000061444.4 NM_025440 Q9CPX7 RT16_MOUSE Rpms16 uc007sjp.1 uc007sjp.2 uc007sjp.3 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the bacterial ribosomal protein bS16 family. structural constituent of ribosome mitochondrion mitochondrial small ribosomal subunit cytosol ribosome translation mitochondrial translation uc007sjp.1 uc007sjp.2 uc007sjp.3 
ENSMUST00000061446.8 Tmem130 ENSMUST00000061446.8 transmembrane protein 130 (from RefSeq NM_177735.4) ENSMUST00000061446.1 ENSMUST00000061446.2 ENSMUST00000061446.3 ENSMUST00000061446.4 ENSMUST00000061446.5 ENSMUST00000061446.6 ENSMUST00000061446.7 NM_177735 Q6NXM3 Q8C4P6 TM130_MOUSE uc009als.1 uc009als.2 uc009als.3 Golgi apparatus membrane ; Single- pass type I membrane protein Sequence=BAC38251.1; Type=Erroneous initiation; Evidence=; Golgi membrane molecular_function Golgi apparatus integral component of plasma membrane biological_process membrane integral component of membrane uc009als.1 uc009als.2 uc009als.3 
ENSMUST00000061450.7 Tmem104 ENSMUST00000061450.7 transmembrane protein 104 (from RefSeq NM_001033393.2) ENSMUST00000061450.1 ENSMUST00000061450.2 ENSMUST00000061450.3 ENSMUST00000061450.4 ENSMUST00000061450.5 ENSMUST00000061450.6 NM_001033393 Q3TB48 Q3U2Y2 TM104_MOUSE uc007mgv.1 uc007mgv.2 uc007mgv.3 uc007mgv.4 Membrane ; Multi-pass membrane protein Belongs to the TMEM104 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007mgv.1 uc007mgv.2 uc007mgv.3 uc007mgv.4 
ENSMUST00000061455.9 Tent5c ENSMUST00000061455.9 terminal nucleotidyltransferase 5C (from RefSeq NM_001142952.1) ENSMUST00000061455.1 ENSMUST00000061455.2 ENSMUST00000061455.3 ENSMUST00000061455.4 ENSMUST00000061455.5 ENSMUST00000061455.6 ENSMUST00000061455.7 ENSMUST00000061455.8 Fam46c NM_001142952 Q0P629 Q5SSF7 Q80XL2 Q9CUN7 TET5C_MOUSE Tent5c uc008qqu.1 uc008qqu.2 uc008qqu.3 uc008qqu.4 Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression (PubMed:34048638). Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich (By similarity). Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein (PubMed:28931820). Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, ChEBI:CHEBI:173115; EC=2.7.7.19; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11333; Evidence=; Interacts with BCCIP and PABPC1; the interaction has no effect on TENT5C poly(A) polymerase function. Interacts with PLK4; this interaction leads to the TENT5C recruitment into the centrosome. Nucleus Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Recruited into the centrosome through its interaction with PLK4. Expressed by splenocytes, expression is increased in activated splenocytes. In splenocytes, expression is highly induced after yctivation by IL4 and LPS. Animals do not display major developmental phenotypes. They suffer from anemia with lower hemoglobin levels compared to controls. They have increased proliferation of B cells. Belongs to the TENT family. Sequence=AAH37072.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH46309.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; in utero embryonic development RNA binding polynucleotide adenylyltransferase activity nucleus cytoplasm transferase activity nucleotidyltransferase activity mRNA stabilization RNA adenylyltransferase activity uc008qqu.1 uc008qqu.2 uc008qqu.3 uc008qqu.4 
ENSMUST00000061456.8 Fbxw13 ENSMUST00000061456.8 F-box and WD-40 domain protein 13 (from RefSeq NM_177598.3) ENSMUST00000061456.1 ENSMUST00000061456.2 ENSMUST00000061456.3 ENSMUST00000061456.4 ENSMUST00000061456.5 ENSMUST00000061456.6 ENSMUST00000061456.7 Fbxw13 NM_177598 Q8BI57 Q8BI57_MOUSE uc009rsc.1 uc009rsc.2 molecular_function cellular_component biological_process uc009rsc.1 uc009rsc.2 
ENSMUST00000061457.7 Csrnp2 ENSMUST00000061457.7 cysteine-serine-rich nuclear protein 2 (from RefSeq NM_153407.2) CSRN2_MOUSE ENSMUST00000061457.1 ENSMUST00000061457.2 ENSMUST00000061457.3 ENSMUST00000061457.4 ENSMUST00000061457.5 ENSMUST00000061457.6 Fam130a1 NM_153407 Q3UIH1 Q8BGQ2 Taip12 uc007xrk.1 uc007xrk.2 uc007xrk.3 Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. May play a role in apoptosis. Nucleus Highest expression detected in thymus, brain and ovary. Low levels detected in naive T-cells. Mice display no obvious defects in development, hematopoiesis or T-cell function. Deletion of Axud1, Csrnp2 and Csrnp3 together causes partial neonatal lethality, suggesting that they have redundant functions. Belongs to the AXUD1 family. transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus apoptotic process negative regulation of phosphatase activity phosphatase binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc007xrk.1 uc007xrk.2 uc007xrk.3 
ENSMUST00000061468.9 Bcl7c ENSMUST00000061468.9 B cell CLL/lymphoma 7C, transcript variant 2 (from RefSeq NM_009746.2) BCL7C_MOUSE ENSMUST00000061468.1 ENSMUST00000061468.2 ENSMUST00000061468.3 ENSMUST00000061468.4 ENSMUST00000061468.5 ENSMUST00000061468.6 ENSMUST00000061468.7 ENSMUST00000061468.8 NM_009746 O08664 Q99LS2 uc009jwl.1 uc009jwl.2 uc009jwl.3 May play an anti-apoptotic role. Down-regulated by IL-10 in a malignant cell line derived from a murine model for chronic lymphocytic leukemia. Belongs to the BCL7 family. molecular_function cellular_component apoptotic process biological_process uc009jwl.1 uc009jwl.2 uc009jwl.3 
ENSMUST00000061469.4 Wfikkn2 ENSMUST00000061469.4 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 (from RefSeq NM_181819.2) ENSMUST00000061469.1 ENSMUST00000061469.2 ENSMUST00000061469.3 Gasp1 NM_181819 Q5SUS5 Q7TQN3 WFKN2_MOUSE uc007kyg.1 uc007kyg.2 uc007kyg.3 uc007kyg.4 Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease- inhibitor activity (By similarity). Inhibits the biological activity of mature myostatin, but not activin. Interacts with both mature and propeptide myostatin/MSTN. Secreted Widely expressed, with high expression in skeletal muscle and heart. Also expressed in brain, lung and testis. Weakly expressed in liver and kidney. Belongs to the WFIKKN family. skeletal system development enzyme inhibitor activity serine-type endopeptidase inhibitor activity protein binding extracellular region extracellular space transforming growth factor beta receptor signaling pathway metalloendopeptidase inhibitor activity negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of protein binding negative regulation of DNA binding receptor antagonist activity muscle fiber development transforming growth factor beta binding palate development negative regulation of receptor activity uc007kyg.1 uc007kyg.2 uc007kyg.3 uc007kyg.4 
ENSMUST00000061481.7 Prss38 ENSMUST00000061481.7 serine protease 38 (from RefSeq NM_001045521.1) B9EJM8 ENSMUST00000061481.1 ENSMUST00000061481.2 ENSMUST00000061481.3 ENSMUST00000061481.4 ENSMUST00000061481.5 ENSMUST00000061481.6 Gm249 Mpn2 NM_001045521 PRS38_MOUSE Q3UKY7 uc007jdr.1 uc007jdr.2 uc007jdr.3 Secreted Belongs to the peptidase S1 family. serine-type endopeptidase activity cellular_component extracellular region proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc007jdr.1 uc007jdr.2 uc007jdr.3 
ENSMUST00000061483.9 Bmyc ENSMUST00000061483.9 brain expressed myelocytomatosis oncogene (from RefSeq NM_023326.2) ENSMUST00000061483.1 ENSMUST00000061483.2 ENSMUST00000061483.3 ENSMUST00000061483.4 ENSMUST00000061483.5 ENSMUST00000061483.6 ENSMUST00000061483.7 ENSMUST00000061483.8 MYCB_MOUSE Mycb NM_023326 Q6P8Z1 Q9D6E3 uc008itg.1 uc008itg.2 uc008itg.3 uc008itg.4 Seems to act as an inhibitor of cellular proliferation. Nucleus Highly expressed in epididymis. Also expressed in hypothalamus, pituitary, uterus and ovary. Low expression in testis. Not detected in heart. Rapidly degraded via the ubiquitin-proteasome pathway. Sequence=BAB28992.1; Type=Frameshift; Evidence=; transcription factor activity, sequence-specific DNA binding protein binding nucleus spindle regulation of transcription, DNA-templated uc008itg.1 uc008itg.2 uc008itg.3 uc008itg.4 
ENSMUST00000061491.14 Slc27a2 ENSMUST00000061491.14 solute carrier family 27 (fatty acid transporter), member 2 (from RefSeq NM_011978.2) Acsvl1 ENSMUST00000061491.1 ENSMUST00000061491.10 ENSMUST00000061491.11 ENSMUST00000061491.12 ENSMUST00000061491.13 ENSMUST00000061491.2 ENSMUST00000061491.3 ENSMUST00000061491.4 ENSMUST00000061491.5 ENSMUST00000061491.6 ENSMUST00000061491.7 ENSMUST00000061491.8 ENSMUST00000061491.9 Facvl1 Fatp2 NM_011978 O35488 O70550 O88560 Q91WV6 S27A2_MOUSE Vlacs Vlcs uc008mdq.1 uc008mdq.2 uc008mdq.3 Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (PubMed:9671728, PubMed:15699031, PubMed:20530735). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:15699031, PubMed:20530735). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:15699031, PubMed:20530735). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (By similarity). May contribute to the synthesis of sphingosine-1-phosphate (By similarity). Does not activate C24 bile acids, cholate and chenodeoxycholate (By similarity). In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. However, it is not critical for THCA activation and bile synthesis in vivo (By similarity). Reaction=a fatty acid(in) = a fatty acid(out); Xref=Rhea:RHEA:38879, ChEBI:CHEBI:28868; Evidence= Reaction=(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in); Xref=Rhea:RHEA:33655, ChEBI:CHEBI:30823; Evidence=; Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl- CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:456215; EC=6.2.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19714; Evidence=; Reaction=(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:33607, ChEBI:CHEBI:30616, ChEBI:CHEBI:30823, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33608; Evidence=; Reaction=(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA = (9Z,12Z,15Z)- octadecatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:44936, ChEBI:CHEBI:30616, ChEBI:CHEBI:32387, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:74034, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44937; Evidence=; Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl- CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30752; Evidence=; Reaction=2,6,10,14-tetramethylpentadecanoate + ATP + CoA = AMP + diphosphate + pristanoyl-CoA; Xref=Rhea:RHEA:47264, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:77250, ChEBI:CHEBI:77268, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47265; Evidence=; Reaction=(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:36139, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61526, ChEBI:CHEBI:72745, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36140; Evidence=; Reaction=3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA; Xref=Rhea:RHEA:21380, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:37257, ChEBI:CHEBI:57287, ChEBI:CHEBI:57391, ChEBI:CHEBI:456215; EC=6.2.1.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21381; Evidence=; Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537; Evidence=; Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616, ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:44932, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:74298, ChEBI:CHEBI:77016, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44933; Evidence=; Reaction=(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan- 26-oyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:22976, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58677, ChEBI:CHEBI:58734, ChEBI:CHEBI:456215; EC=6.2.1.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22977; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Peroxisome membrane ; Peripheral membrane protein Cell membrane ; Multi-pass membrane protein Microsome Strong expression in liver and kidney (at protein level) (PubMed:20530735, PubMed:11980911, PubMed:9671728). Lower expression in brain and testis, no expression in skeletal muscle and spleen (PubMed:11980911). Shows uniform distribution in liver acinus (PubMed:11980911). Conditional knockout in liver results in decreased long-chain fatty acids (LCFA) uptake by hepatocytes and decreased peroxisomal long chain and very long-chain acyl-CoA synthetase (VLACS) activity. Belongs to the ATP-dependent AMP-binding enzyme family. Sequence=AAC40186.1; Type=Frameshift; Evidence=; very long-chain fatty acid metabolic process nucleotide binding fatty acid alpha-oxidation long-chain fatty acid metabolic process catalytic activity acyl-CoA ligase activity long-chain fatty acid-CoA ligase activity long-chain fatty acid transporter activity ATP binding mitochondrion peroxisome peroxisomal membrane integral component of peroxisomal membrane endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane plasma membrane lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation bile acid biosynthetic process fatty acid transporter activity fatty acid transport membrane integral component of membrane ligase activity enzyme binding integral component of endoplasmic reticulum membrane very long-chain fatty acid-CoA ligase activity very long-chain fatty acid catabolic process intracellular membrane-bounded organelle long-chain fatty acid import arachidonate-CoA ligase activity cholate-CoA ligase activity phytanate-CoA ligase activity pristanate-CoA ligase activity methyl-branched fatty acid metabolic process decanoate--CoA ligase activity uc008mdq.1 uc008mdq.2 uc008mdq.3 
ENSMUST00000061496.17 Tcf7l2 ENSMUST00000061496.17 transcription factor 7 like 2, T cell specific, HMG box, transcript variant 3 (from RefSeq NM_009333.4) ENSMUST00000061496.1 ENSMUST00000061496.10 ENSMUST00000061496.11 ENSMUST00000061496.12 ENSMUST00000061496.13 ENSMUST00000061496.14 ENSMUST00000061496.15 ENSMUST00000061496.16 ENSMUST00000061496.2 ENSMUST00000061496.3 ENSMUST00000061496.4 ENSMUST00000061496.5 ENSMUST00000061496.6 ENSMUST00000061496.7 ENSMUST00000061496.8 ENSMUST00000061496.9 F6WBK9 F6WBK9_MOUSE NM_009333 Tcf7l2 uc008hyg.1 uc008hyg.2 uc008hyg.3 uc008hyg.4 uc008hyg.5 Nucleus Belongs to the TCF/LEF family. DNA binding nucleus Wnt signaling pathway uc008hyg.1 uc008hyg.2 uc008hyg.3 uc008hyg.4 uc008hyg.5 
ENSMUST00000061497.9 Cryga ENSMUST00000061497.9 crystallin, gamma A (from RefSeq NM_007774.4) CRGA_MOUSE ENSMUST00000061497.1 ENSMUST00000061497.2 ENSMUST00000061497.3 ENSMUST00000061497.4 ENSMUST00000061497.5 ENSMUST00000061497.6 ENSMUST00000061497.7 ENSMUST00000061497.8 NM_007774 P04345 uc007bhk.1 uc007bhk.2 uc007bhk.3 Three main families of major soluble proteins, the alpha, beta and gamma crystallins, are ubiquitously expressed in vertebrate lenses. This gene encodes a member of the gamma-crystallin family of proteins which may function as a structural component of the eye lens. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Five gamma-crystallin genes (gamma-A through gamma-E) are tandemly organized in a genomic segment as a gene cluster in the mouse. Another gamma-crystallin gene (gamma-F) is found some distance upstream of the cluster on the same chromosome. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CN539000.1, CF738355.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139, SAMN01164142 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Crystallins are the dominant structural components of the vertebrate eye lens. Has a two-domain beta-structure, folded into four very similar Greek key motifs. There are six different gamma crystallins identified in mouse lens. Belongs to the beta/gamma-crystallin family. eye development lens development in camera-type eye structural constituent of eye lens visual perception uc007bhk.1 uc007bhk.2 uc007bhk.3 
ENSMUST00000061498.7 Fut4 ENSMUST00000061498.7 fucosyltransferase 4 (from RefSeq NM_010242.3) ENSMUST00000061498.1 ENSMUST00000061498.2 ENSMUST00000061498.3 ENSMUST00000061498.4 ENSMUST00000061498.5 ENSMUST00000061498.6 Fut4 NM_010242 Q544B8 Q544B8_MOUSE uc009oew.1 uc009oew.2 uc009oew.3 Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L- fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+); Xref=Rhea:RHEA:14257, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133507, ChEBI:CHEBI:137941; EC=2.4.1.152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14258; Evidence=; Reaction=an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)- N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D- GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:56076, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:136545, ChEBI:CHEBI:139509; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56077; Evidence=; Reaction=an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)- beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D- Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:68044, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:145343, ChEBI:CHEBI:176900; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68045; Evidence=; Reaction=an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal- (1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+); Xref=Rhea:RHEA:62004, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:145344, ChEBI:CHEBI:145345; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62005; Evidence=; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 10 family. Golgi apparatus protein glycosylation fucosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups Golgi cisterna membrane fucosylation uc009oew.1 uc009oew.2 uc009oew.3 
ENSMUST00000061506.9 Tmtc2 ENSMUST00000061506.9 transmembrane and tetratricopeptide repeat containing 2 (from RefSeq NM_177368.4) B2RRD8 ENSMUST00000061506.1 ENSMUST00000061506.2 ENSMUST00000061506.3 ENSMUST00000061506.4 ENSMUST00000061506.5 ENSMUST00000061506.6 ENSMUST00000061506.7 ENSMUST00000061506.8 NM_177368 Q56A06 Q5U620 Q8C787 TMTC2_MOUSE uc007gym.1 uc007gym.2 uc007gym.3 uc007gym.4 Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3. Reaction=a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3- O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+); Xref=Rhea:RHEA:17377, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:13546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:137321; EC=2.4.1.109; Evidence=; Reaction=a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+); Xref=Rhea:RHEA:53396, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13547, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:137323; EC=2.4.1.109; Evidence=; Protein modification; protein glycosylation. Membrane ; Multi-pass membrane protein Endoplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q56A06-1; Sequence=Displayed; Name=2; IsoId=Q56A06-2; Sequence=VSP_023628, VSP_023629; Belongs to the TMTC family. mannosyltransferase activity dolichyl-phosphate-mannose-protein mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation membrane integral component of membrane transferase activity protein O-linked mannosylation calcium ion homeostasis uc007gym.1 uc007gym.2 uc007gym.3 uc007gym.4 
ENSMUST00000061508.8 Zfp358 ENSMUST00000061508.8 zinc finger protein 358 (from RefSeq NM_080461.2) E9Q8M1 E9Q8M1_MOUSE ENSMUST00000061508.1 ENSMUST00000061508.2 ENSMUST00000061508.3 ENSMUST00000061508.4 ENSMUST00000061508.5 ENSMUST00000061508.6 ENSMUST00000061508.7 NM_080461 Zfp358 uc009krp.1 uc009krp.2 nucleic acid binding uc009krp.1 uc009krp.2 
ENSMUST00000061516.8 Fpr1 ENSMUST00000061516.8 formyl peptide receptor 1 (from RefSeq NM_013521.2) ENSMUST00000061516.1 ENSMUST00000061516.2 ENSMUST00000061516.3 ENSMUST00000061516.4 ENSMUST00000061516.5 ENSMUST00000061516.6 ENSMUST00000061516.7 FPR1_MOUSE NM_013521 P33766 Q3UV01 uc008apt.1 uc008apt.2 uc008apt.3 High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (By similarity). Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (By similarity). Cell membrane ; Multi-pass membrane protein Note=Internalizes in presence of its ligand, TAFA4. Expressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ. Phosphorylated; which is necessary for desensitization. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor binding complement receptor mediated signaling pathway G-protein coupled receptor activity N-formyl peptide receptor activity scavenger receptor binding cytoplasm plasma membrane chemotaxis inflammatory response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane RAGE receptor binding uc008apt.1 uc008apt.2 uc008apt.3 
ENSMUST00000061522.8 Dnd1 ENSMUST00000061522.8 DND microRNA-mediated repression inhibitor 1 (from RefSeq NM_173383.2) DND1_MOUSE ENSMUST00000061522.1 ENSMUST00000061522.2 ENSMUST00000061522.3 ENSMUST00000061522.4 ENSMUST00000061522.5 ENSMUST00000061522.6 ENSMUST00000061522.7 NM_173383 Q6VY05 Q8CFK7 Rbms4 Ter uc008eon.1 uc008eon.2 uc008eon.3 RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression (By similarity). Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Isoform 1 may play a role during primordial germ cell (PGC) survival. However, does not seem to be essential for PGC migration. Interacts with APOBEC3. Nucleus. Cytoplasm. Note=Perinuclear germ granules, also called germ plasm or chromatoid body (By similarity). Colocalizes in perinuclear sites with APOBEC3. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=DND1-alpha; IsoId=Q6VY05-1; Sequence=Displayed; Name=2; Synonyms=DND1-beta; IsoId=Q6VY05-2; Sequence=VSP_012943; Isoform 1 and isoform 2 are expressed in testis. Isoform 1 is expressed continuously in post natal (PN) testis although levels are low between PN1 to PN6. Isoform 2 is expressed from PN 20 onwards. Isoform 2 is strongly expressed in meiotic and in post-meiotic germ cells of the testis with highest expression at the elongated spermatid stage (at protein level). Expressed in testis and heart. Expressed in germ cells and genital ridges. Not detected in testicular tumors. Isoform 1, but not isoform 2, is expressed in embryos at 13.5 and 15.5 dpc. Isoform 1, but not isoform 2, is expressed in primordial gonads at 13.5 and 15.5 dpc. Isoform 1, but not isoform 2, is expressed in ES cell lines. Isoform 1, but not isoform 2, is expressed in embryonic germ (EG) cells (at protein level). Detected in the embryo and allantoic bud at 7.5 dpc, in the neuroectoderm at 8.5 dpc, and widespread at 9.5 dpc, including the neural tube, head mesenchyme, first branchial arch and the hindgut, through which primordial germ cells are migrating. At 11.5 dpc, also expressed in the XY and XX genital ridges. Expressed in genital ridges at 13.5 dpc. Between 12.5 to 14.5 dpc, up-regulated in the testis cords of the XY gonads and down-regulated in XX gonads. Down-regulation occurs progressively as an anterior to posterior wave. Note=Defects in Dnd1 are the cause of the Ter mutation phenotype. Ter mice are characterized by primordial germ cell loss and susceptibility to spontaneous testicular germ cell tumors (TGCT). They are sterile, but viable. Isoform 1 defects may be the cause of tumor development. [Isoform 2]: May be due to intron retention. nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding nucleus cytoplasm multicellular organism development germ cell development mRNA stabilization negative regulation of gene silencing by miRNA miRNA binding uc008eon.1 uc008eon.2 uc008eon.3 
ENSMUST00000061537.14 ENSMUSG00000121798 ENSMUST00000061537.14 ENSMUSG00000121798 (from geneSymbol) BC055845 ENSMUST00000061537.1 ENSMUST00000061537.10 ENSMUST00000061537.11 ENSMUST00000061537.12 ENSMUST00000061537.13 ENSMUST00000061537.2 ENSMUST00000061537.3 ENSMUST00000061537.4 ENSMUST00000061537.5 ENSMUST00000061537.6 ENSMUST00000061537.7 ENSMUST00000061537.8 ENSMUST00000061537.9 uc007ddi.1 uc007ddi.2 uc007ddi.3 uc007ddi.4 uc007ddi.5 uc007ddi.1 uc007ddi.2 uc007ddi.3 uc007ddi.4 uc007ddi.5 
ENSMUST00000061545.7 C1ql3 ENSMUST00000061545.7 C1q-like 3 (from RefSeq NM_153155.3) A2AUR9 B0LXL6 C1QL3_MOUSE C1ql Ctrp13 ENSMUST00000061545.1 ENSMUST00000061545.2 ENSMUST00000061545.3 ENSMUST00000061545.4 ENSMUST00000061545.5 ENSMUST00000061545.6 NM_153155 Q9ESN4 uc008ijv.1 uc008ijv.2 uc008ijv.3 May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC1 and PCK1 and hence decreases de novo glucose production. Forms homooligomers. Interacts with ADGRB3 (PubMed:21262840). Forms heterooligomers with C1QL2 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion. Q9ESN4; Q9ESN4: C1ql3; NbExp=3; IntAct=EBI-15907894, EBI-15907894; Q9ESN4; O60242: ADGRB3; Xeno; NbExp=4; IntAct=EBI-15907894, EBI-2682765; Secreted Highly expressed in brain and white adipose tissue. In gonadal fat pad, expressed at lower levels in adipocytes than in the stromal vascular fraction (VSP), which contains preadipocytes, fibroblasts, endothelial cells and occasional immune cells. Expression exhibits sexually dimorphism, with higher levels in females than in males (at protein level). Tends to be up-regulated in adipose tissue from obese males, but not females. Expressed in glial cells. In adipocytes, up-regulated by rosiglitazone, an insulin- sensitizing drug. protein binding extracellular region collagen trimer identical protein binding regulation of synapse organization uc008ijv.1 uc008ijv.2 uc008ijv.3 
ENSMUST00000061552.15 Peak1 ENSMUST00000061552.15 pseudopodium-enriched atypical kinase 1 (from RefSeq NM_172924.3) E9QKY2 ENSMUST00000061552.1 ENSMUST00000061552.10 ENSMUST00000061552.11 ENSMUST00000061552.12 ENSMUST00000061552.13 ENSMUST00000061552.14 ENSMUST00000061552.2 ENSMUST00000061552.3 ENSMUST00000061552.4 ENSMUST00000061552.5 ENSMUST00000061552.6 ENSMUST00000061552.7 ENSMUST00000061552.8 ENSMUST00000061552.9 Kiaa2002 NM_172924 PEAK1_MOUSE Q69Z38 Q8BX56 Q8R365 Sgk269 uc009psz.1 uc009psz.2 uc009psz.3 uc009psz.4 uc009psz.5 Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling. Homodimer (By similarity). Interacts with BCAR1 and CRK (By similarity). Interacts with PRAG1 (By similarity). Interacts (when phosphorylated at Tyr-1177) with SHC1 (via PID domain) (By similarity). Found in a complex with PPP1CA, PPP1CC and SHC1 (By similarity). Interacts (when phosphorylated at Tyr-632) with tensin TNS3 (when phosphorylated on the SH2 domain); TNS3 also interacts with integrins ITGB1, ITGB3 and ITGB5 and mediates their association with PEAK1 (PubMed:35687021). Cytoplasm, cytoskeleton Cell junction, focal adhesion Note=Colocalizes with actin (PubMed:20534451). The dimerization region encompasses helices both from the N- and C-terminal of the protein kinase domain. Phosphorylated on tyrosine in a CSK-dependent manner in response to adhesion to fibronectin and to EGF stimulation (PubMed:20534451). Phosphorylation at Tyr-662 by a Src family kinase controls subcellular localization to focal adhesion and focal adhesion dynamics. Phosphorylation at Tyr-1177 is essential for binding to SHC1. Phosphorylation at Tyr-632 promotes interaction with tensin TNS3. Belongs to the protein kinase superfamily. Has been the subject of controversy surrounding its catalytic capabilities. Early characterization of PEAK1 gave a weak in vitro tyrosine kinase activity. The crystal structure indicates that the kinase-domain contains a closed nucleotide-binding cleft that in this conformation may deleteriously affect nucleotide bindin. Furthermore PEAK1 is devoid of nucleotide binding activity, as detected by a thermal-shift assay. So it seems probable that PEAK1 is an inactive kinase. protein kinase activity non-membrane spanning protein tyrosine kinase activity cytoplasm cytoskeleton focal adhesion protein phosphorylation actin cytoskeleton cell migration peptidyl-tyrosine phosphorylation cell junction substrate adhesion-dependent cell spreading identical protein binding protein autophosphorylation focal adhesion assembly regulation of focal adhesion assembly ATP binding uc009psz.1 uc009psz.2 uc009psz.3 uc009psz.4 uc009psz.5 
ENSMUST00000061568.9 Slc36a4 ENSMUST00000061568.9 solute carrier family 36 (proton/amino acid symporter), member 4, transcript variant 1 (from RefSeq NM_172289.5) A0A0R4J0Q3 A0A0R4J0Q3_MOUSE ENSMUST00000061568.1 ENSMUST00000061568.2 ENSMUST00000061568.3 ENSMUST00000061568.4 ENSMUST00000061568.5 ENSMUST00000061568.6 ENSMUST00000061568.7 ENSMUST00000061568.8 NM_172289 Slc36a4 uc009ogg.1 uc009ogg.2 uc009ogg.3 L-alanine transmembrane transporter activity L-proline transmembrane transporter activity L-tryptophan transmembrane transporter activity L-alanine transport proline transport tryptophan transport membrane integral component of membrane proline transmembrane transport uc009ogg.1 uc009ogg.2 uc009ogg.3 
ENSMUST00000061571.5 Neurod4 ENSMUST00000061571.5 neurogenic differentiation 4, transcript variant 3 (from RefSeq NM_007501.5) ENSMUST00000061571.1 ENSMUST00000061571.2 ENSMUST00000061571.3 ENSMUST00000061571.4 NM_007501 Neurod4 Q545C0 Q545C0_MOUSE uc007hri.1 uc007hri.2 uc007hri.3 This gene belongs to the neurogenic differentiation factor family and encodes a basic helix-loop-helix (bHLH) transcription factor which is expressed in the developing nervous system with high levels of expression in the brain, retina and cranial ganglions. Expression gradually becomes restricted to the neural retina. It is a key gene in the Ngn2-regulated neuronal differentiation pathway, coordinating the onset of cortical gene transcription. This gene also regulates amacrine cell fate determination in the retina. [provided by RefSeq, Jul 2016]. Nucleus DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development nervous system development cell differentiation positive regulation of cell differentiation protein dimerization activity neuron development retina development in camera-type eye uc007hri.1 uc007hri.2 uc007hri.3 
ENSMUST00000061578.9 Setx ENSMUST00000061578.9 senataxin (from RefSeq NM_198033.2) A2AKX3 A2AKX4 A2AR33 Als4 ENSMUST00000061578.1 ENSMUST00000061578.2 ENSMUST00000061578.3 ENSMUST00000061578.4 ENSMUST00000061578.5 ENSMUST00000061578.6 ENSMUST00000061578.7 ENSMUST00000061578.8 Kiaa0625 NM_198033 Q6IMG6 Q6PED8 Q6ZQ81 Q80V90 Q8C5P1 Q8C859 Q8C8P6 SETX_MOUSE Setx uc008izm.1 uc008izm.2 Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription. Contributes to the mRNA splicing efficiency and splice site selection. Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (By similarity). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (PubMed:22767893). Involved in DNA double-strand breaks damage response generated by oxidative stress. In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (By similarity). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (PubMed:23593030). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis. May be involved in telomeric stability through the regulation of telomere repeat- containing RNA (TERRA) transcription (By similarity). Homodimer (By similarity). Interacts with PER2; the interaction inhibits termination of circadian target genes (PubMed:22767893). Interacts with CHD4, POLR2A, PRKDC and TRIM28. Does not interact with C14orf178. Interacts with UBE2I. Interacts (via N- terminus domain) with EXOSC9 (via C-terminus region); the interaction enhances SETX sumoylation. Interacts with NCL (via N-terminus domain). Interacts with PABPN1, PABPC1 and SF3B1. Interacts with SMN1/SMN2 and POLR2A; SMN1/SMN2 recruits SETX to POLR2A (By similarity). Nucleus Nucleus, nucleoplasm Nucleus, nucleolus Cytoplasm Chromosome Chromosome, telomere Cell projection, axon Cell projection, growth cone Note=Most abundant in the nucleus (By similarity). Detected in granules (By similarity). Colocalized in cycling cells with FBL in the nucleolus. Localizes with telomeric DNA in a transcription-dependent manner. Under replication stress, colocalizes with a variety of DNA damage signaling and repair response proteins at distinct nuclear foci in mitotic S/G2- and G1-phase cells in a transcription- and RNA/DNA hybrid-dependent manner. Localizes at limited number of nuclear foci. Colocalizes with EXOSC9 in nuclear foci upon induction of transcription-related DNA damage at the S phase (By similarity). At pachytene stage, colocalizes predominantly to the heterochromatic XY-body of sex chromosomes with DNA damage response proteins in a BRCA1-dependent manner (PubMed:23593030). May be detected in the nucleolus only in cycling cells (PubMed:16644229). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AKX3-1; Sequence=Displayed; Name=2; IsoId=A2AKX3-2; Sequence=VSP_028827; Expressed in cerebellum, hippocampus, olfactory bulb, Bergmann glial fibers, stellate cells and Purkinje cells. Expressed in the epithelial cells of the lens but not in mature lens fiber cells. Expressed in the retina (highly expressed in inner and outer segments of photoreceptors and outer plexiform layer cells but weakly expressed in the inner plexiform and ganglion cell layers). Expressed in the kidney. The N-terminus domain is necessary for S/G2 nuclear foci localization. Ubiquitinated. Sumoylated preferentially with SUMO2 or SUMO3. Mice are viable. Male germ cells proceed normally from spermatogonia up to the meiotic pachytene stage but fail to enter into spermiogenesis and form mature spermatids (PubMed:23593030), resulting in male infertility. In particular, during spermatogenesis, male germ cells accumulated DNA:RNA hybrids (R-loops), meiotic DNA double-strand breaks, and fails to produce crossovers and meiotic sex chromosome inactivation (MSCI) (PubMed:23593030). Belongs to the DNA2/NAM7 helicase family. Sequence=BAC32054.1; Type=Frameshift; Evidence=; Sequence=BAC97987.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it is derived from pre-RNA.; Evidence=; MAPK cascade nucleotide binding nuclear chromosome chromosome, telomeric region transcription termination site sequence-specific DNA binding RNA binding helicase activity protein binding ATP binding nucleus nucleoplasm chromosome nucleolus cytoplasm DNA repair double-strand break repair DNA recombination DNA-templated transcription, termination termination of RNA polymerase II transcription mRNA splice site selection cellular response to DNA damage stimulus spermatogenesis nervous system development circadian rhythm fibroblast growth factor receptor signaling pathway positive regulation of neuron projection development nuclear body hydrolase activity cell differentiation axon growth cone positive regulation of RNA splicing cellular response to oxidative stress identical protein binding cell projection negative regulation of apoptotic process protein kinase B signaling cellular response to fibroblast growth factor stimulus intercellular bridge positive regulation of transcription from RNA polymerase II promoter rhythmic process positive regulation of DNA-templated transcription, termination cellular response to hydrogen peroxide cellular response to retinoic acid positive regulation of DNA-templated transcription, initiation positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled uc008izm.1 uc008izm.2 
ENSMUST00000061586.11 Zfp507 ENSMUST00000061586.11 zinc finger protein 507 (from RefSeq NM_177739.3) ENSMUST00000061586.1 ENSMUST00000061586.10 ENSMUST00000061586.2 ENSMUST00000061586.3 ENSMUST00000061586.4 ENSMUST00000061586.5 ENSMUST00000061586.6 ENSMUST00000061586.7 ENSMUST00000061586.8 ENSMUST00000061586.9 Kiaa1084 NM_177739 Q3UQU3 Q6ZPY5 Q80VK1 ZN507_MOUSE Znf507 uc009gkh.1 uc009gkh.2 uc009gkh.3 uc009gkh.4 uc009gkh.5 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC98093.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009gkh.1 uc009gkh.2 uc009gkh.3 uc009gkh.4 uc009gkh.5 
ENSMUST00000061587.13 Orai3 ENSMUST00000061587.13 ORAI calcium release-activated calcium modulator 3 (from RefSeq NM_198424.3) ENSMUST00000061587.1 ENSMUST00000061587.10 ENSMUST00000061587.11 ENSMUST00000061587.12 ENSMUST00000061587.2 ENSMUST00000061587.3 ENSMUST00000061587.4 ENSMUST00000061587.5 ENSMUST00000061587.6 ENSMUST00000061587.7 ENSMUST00000061587.8 ENSMUST00000061587.9 NM_198424 ORAI3_MOUSE Q6P8G8 Tmem142c uc009jwr.1 uc009jwr.2 Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1. Interacts with CRACR2A/EFCAB4B. Cell membrane ; Multi-pass membrane protein Belongs to the Orai family. store-operated calcium entry store-operated calcium channel activity membrane integral component of membrane calcium ion transmembrane transport uc009jwr.1 uc009jwr.2 
ENSMUST00000061594.13 Ankrd34b ENSMUST00000061594.13 ankyrin repeat domain 34B (from RefSeq NM_175455.4) AN34B_MOUSE Dp58 ENSMUST00000061594.1 ENSMUST00000061594.10 ENSMUST00000061594.11 ENSMUST00000061594.12 ENSMUST00000061594.2 ENSMUST00000061594.3 ENSMUST00000061594.4 ENSMUST00000061594.5 ENSMUST00000061594.6 ENSMUST00000061594.7 ENSMUST00000061594.8 ENSMUST00000061594.9 NM_175455 Q3UUF8 Q4VA01 Q8BVH7 uc007rkn.1 uc007rkn.2 uc007rkn.3 uc007rkn.4 Cytoplasm Nucleus Specifically and constitutively expressed in brain (at protein level). Up-regulated in bone marrow upon differentiation (at protein level). Phosphorylated. Belongs to the ANKRD34 family. Sequence=AAH96609.1; Type=Frameshift; Evidence=; molecular_function cellular_component nucleus cytoplasm biological_process uc007rkn.1 uc007rkn.2 uc007rkn.3 uc007rkn.4 
ENSMUST00000061597.7 4921517D22Rik ENSMUST00000061597.7 RIKEN cDNA 4921517D22 gene (from RefSeq NM_183290.2) 4921517D22Rik ENSMUST00000061597.1 ENSMUST00000061597.2 ENSMUST00000061597.3 ENSMUST00000061597.4 ENSMUST00000061597.5 ENSMUST00000061597.6 NM_183290 Q8CET0 Q8CET0_MOUSE uc007quy.1 uc007quy.2 uc007quy.3 molecular_function cellular_component biological_process uc007quy.1 uc007quy.2 uc007quy.3 
ENSMUST00000061601.9 Ust ENSMUST00000061601.9 uronyl-2-sulfotransferase (from RefSeq NM_177387.3) B2RR02 ENSMUST00000061601.1 ENSMUST00000061601.2 ENSMUST00000061601.3 ENSMUST00000061601.4 ENSMUST00000061601.5 ENSMUST00000061601.6 ENSMUST00000061601.7 ENSMUST00000061601.8 NM_177387 Q8BUB6 UST_MOUSE uc007eit.1 uc007eit.2 uc007eit.3 Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N- resulfated heparin (By similarity). Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the sulfotransferase 3 family. Sequence=BAC39625.1; Type=Frameshift; Evidence=; Golgi membrane Golgi apparatus sulfotransferase activity membrane integral component of membrane transferase activity establishment of cell polarity regulation of axonogenesis uc007eit.1 uc007eit.2 uc007eit.3 
ENSMUST00000061611.15 Rps6kc1 ENSMUST00000061611.15 ribosomal protein S6 kinase polypeptide 1 (from RefSeq NM_178775.4) E9QMX4 E9QMX4_MOUSE ENSMUST00000061611.1 ENSMUST00000061611.10 ENSMUST00000061611.11 ENSMUST00000061611.12 ENSMUST00000061611.13 ENSMUST00000061611.14 ENSMUST00000061611.2 ENSMUST00000061611.3 ENSMUST00000061611.4 ENSMUST00000061611.5 ENSMUST00000061611.6 ENSMUST00000061611.7 ENSMUST00000061611.8 ENSMUST00000061611.9 NM_178775 Rps6kc1 uc007ebi.1 uc007ebi.2 uc007ebi.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; protein kinase activity ATP binding early endosome protein phosphorylation phosphatidylinositol binding uc007ebi.1 uc007ebi.2 uc007ebi.3 
ENSMUST00000061614.8 Gja3 ENSMUST00000061614.8 gap junction protein, alpha 3, transcript variant 1 (from RefSeq NM_016975.3) B2RRM1 CXA3_MOUSE ENSMUST00000061614.1 ENSMUST00000061614.2 ENSMUST00000061614.3 ENSMUST00000061614.4 ENSMUST00000061614.5 ENSMUST00000061614.6 ENSMUST00000061614.7 NM_016975 Q64448 uc007ucw.1 uc007ucw.2 uc007ucw.3 uc007ucw.4 Structural component of lens fiber gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore. A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels. Forms heteromeric channels with GJA8. Cell membrane ; Multi-pass membrane protein Cell junction, gap junction Belongs to the connexin family. Alpha-type (group II) subfamily. gap junction channel activity plasma membrane integral component of plasma membrane gap junction connexin complex cell communication visual perception response to pH membrane integral component of membrane cell junction response to hydrogen peroxide identical protein binding membrane raft gap junction hemi-channel activity transmembrane transport gap junction-mediated intercellular transport uc007ucw.1 uc007ucw.2 uc007ucw.3 uc007ucw.4 
ENSMUST00000061617.7 Zfp280b ENSMUST00000061617.7 zinc finger protein 280B (from RefSeq NM_177475.3) ENSMUST00000061617.1 ENSMUST00000061617.2 ENSMUST00000061617.3 ENSMUST00000061617.4 ENSMUST00000061617.5 ENSMUST00000061617.6 NM_177475 Q505F4 Q505F4_MOUSE Suhw2 Zfp280b uc007ftw.1 uc007ftw.2 uc007ftw.3 uc007ftw.4 nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated uc007ftw.1 uc007ftw.2 uc007ftw.3 uc007ftw.4 
ENSMUST00000061618.9 Patl1 ENSMUST00000061618.9 protein associated with topoisomerase II homolog 1 (yeast), transcript variant 1 (from RefSeq NM_172635.4) ENSMUST00000061618.1 ENSMUST00000061618.2 ENSMUST00000061618.3 ENSMUST00000061618.4 ENSMUST00000061618.5 ENSMUST00000061618.6 ENSMUST00000061618.7 ENSMUST00000061618.8 NM_172635 PATL1_MOUSE Q3TC46 Q3TD30 Q3U4Q3 Q3UD09 Q6PD49 Q8BN50 Q8C3S7 uc008gth.1 uc008gth.2 uc008gth.3 uc008gth.4 RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. Interacts (via region A) with DDX6/RCK. Interacts (via region H and region C) with LSM1 and LSM4. Interacts (via region N) with DCP1A, DCP2, EDC3, EDC4 and XRN1. Interacts with the CCR4-NOT complex. Interacts with the Lsm-containing SMN-Sm protein complex. Interacts with EIF4ENIF1/4E-T. Cytoplasm, P-body Nucleus Nucleus, PML body Nucleus speckle Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus. The region C, also named Pat-C, is required for RNA-binding and mediates the binding with the Lsm-containing SMN-Sm protein complex and the decapping machinery. It folds into an alpha-alpha superhelix, exposing conserved and basic residues on one side of the domain. Belongs to the PAT1 family. deadenylation-dependent decapping of nuclear-transcribed mRNA P-body G-quadruplex RNA binding RNA binding nucleus cytoplasm poly(U) RNA binding PML body nuclear speck negative regulation of translation CCR4-NOT complex translation repressor activity cytoplasmic mRNA processing body assembly poly(G) binding cytoplasmic ribonucleoprotein granule uc008gth.1 uc008gth.2 uc008gth.3 uc008gth.4 
ENSMUST00000061620.17 Unc80 ENSMUST00000061620.17 unc-80, NALCN activator, transcript variant 2 (from RefSeq NM_175510.4) B2KGE8 B2KGG4 B8XCJ6 ENSMUST00000061620.1 ENSMUST00000061620.10 ENSMUST00000061620.11 ENSMUST00000061620.12 ENSMUST00000061620.13 ENSMUST00000061620.14 ENSMUST00000061620.15 ENSMUST00000061620.16 ENSMUST00000061620.2 ENSMUST00000061620.3 ENSMUST00000061620.4 ENSMUST00000061620.5 ENSMUST00000061620.6 ENSMUST00000061620.7 ENSMUST00000061620.8 ENSMUST00000061620.9 Kiaa1843 NM_175510 Q69Z93 Q8BJN5 Q8BLN6 Q8BLP6 UNC80_MOUSE uc007bih.1 uc007bih.2 uc007bih.3 uc007bih.4 Auxiliary subunit of the NALCN sodium channel complex (PubMed:32620897, PubMed:19092807, PubMed:21040849). The NALCN sodium channel complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (PubMed:32620897). This complex is activated by neuropeptides substance P, neurotensin. In addition, the channel is inhibited by extracellular Ca(2+) through the Ca(2+)-sensing receptor. UNC80 is essential for NALCN sensitivity to extracellular calcium. NALCN complex consists of NALCN and auxiliary subunits, UNC79, UNC80 and NACL1 (PubMed:32620897, PubMed:19092807, PubMed:21040849, PubMed:26708751). These auxiliary subunits are essential for the NALCN complex function (PubMed:32620897). Interacts (via N-terminus half) with NALCN; this interaction facilitates NALCN surface localization (PubMed:19092807, PubMed:21040849, PubMed:32620897). Interacts (via C- terminus) with UNC79 (PubMed:19092807, PubMed:21040849, PubMed:32620897, PubMed:26708751). UNC80 bridges NALCN to UNC79 (PubMed:21040849, PubMed:32620897). Q8BLN6; Q8BXR5: Nalcn; NbExp=2; IntAct=EBI-15747640, EBI-11570410; Cell membrane ; Multi-pass membrane protein Cell projection, dendrite Note=In neurons, located in soma and dendrites. Event=Alternative splicing; Named isoforms=2; Comment=Named isoforms=2.; Name=1; IsoId=Q8BLN6-1; Sequence=Displayed; Name=2; IsoId=Q8BLN6-2; Sequence=VSP_015007, VSP_015008; Expressed almost exclusively in the brain (PubMed:26708753). Expressed in hippocampus and ventral tegmental area neurons (PubMed:19092807). Phosphorylated on tyrosine residues. Knockout leads to severe apnea and neonatal lethality. No mice pups survive beyond 24 hours of birth. Hippocampal neurons show decreased NALCN-dependent sodium leak current. Belongs to the unc-80 family. Sequence=BAC31737.1; Type=Frameshift; Evidence=; cation channel activity protein binding membrane integral component of membrane axon ion transmembrane transport cation channel complex cation homeostasis cation transmembrane transport uc007bih.1 uc007bih.2 uc007bih.3 uc007bih.4 
ENSMUST00000061628.7 Pcdh20 ENSMUST00000061628.7 protocadherin 20 (from RefSeq NM_178685.5) E9QK76 ENSMUST00000061628.1 ENSMUST00000061628.2 ENSMUST00000061628.3 ENSMUST00000061628.4 ENSMUST00000061628.5 ENSMUST00000061628.6 NM_178685 PCD20_MOUSE Q8BIV2 Q8BIZ0 uc007uuh.1 uc007uuh.2 uc007uuh.3 uc007uuh.4 This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in cell adhesion in the nervous system and has been shown to be specifically expressed in newly differentiated olfactory sensory neurons and their axons during development. In adult mice, the expression of this protein in the olfactory system is more restricted but shows a gender difference with higher expression in the male than in the female. [provided by RefSeq, Sep 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK083114.1, BB653201.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164132, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Potential calcium-dependent cell-adhesion protein. Cell membrane ; Single-pass type I membrane protein Sequence=BAC34009.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc007uuh.1 uc007uuh.2 uc007uuh.3 uc007uuh.4 
ENSMUST00000061632.9 Trhde ENSMUST00000061632.9 Trhde (from geneSymbol) BC032288 ENSMUST00000061632.1 ENSMUST00000061632.2 ENSMUST00000061632.3 ENSMUST00000061632.4 ENSMUST00000061632.5 ENSMUST00000061632.6 ENSMUST00000061632.7 ENSMUST00000061632.8 uc007hat.1 uc007hat.2 uc007hat.3 uc007hat.4 uc007hat.1 uc007hat.2 uc007hat.3 uc007hat.4 
ENSMUST00000061639.10 Spty2d1 ENSMUST00000061639.10 SPT2 chromatin protein domain containing 1 (from RefSeq NM_175318.4) ENSMUST00000061639.1 ENSMUST00000061639.2 ENSMUST00000061639.3 ENSMUST00000061639.4 ENSMUST00000061639.5 ENSMUST00000061639.6 ENSMUST00000061639.7 ENSMUST00000061639.8 ENSMUST00000061639.9 NM_175318 Q68FG3 Q8BIR1 SPT2_MOUSE uc009gzx.1 uc009gzx.2 uc009gzx.3 uc009gzx.4 Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity). Interacts with histones. Interacts with a heterotetrameric complex formed by histone H3 and H4, especially when the histone tetramer is not bound to DNA. Interacts with histone H3.3 (By similarity). Nucleus, nucleolus The acidic C-terminal domain mediates interaction with histone H3/H4 complexes. Belongs to the SPT2 family. RNA polymerase I core binding DNA binding nucleus nucleolus nucleosome assembly regulation of transcription, DNA-templated regulation of chromatin assembly histone binding histone exchange uc009gzx.1 uc009gzx.2 uc009gzx.3 uc009gzx.4 
ENSMUST00000061643.5 2610303G11Rik ENSMUST00000061643.5 2610303G11Rik (from geneSymbol) AK011970 ENSMUST00000061643.1 ENSMUST00000061643.2 ENSMUST00000061643.3 ENSMUST00000061643.4 uc292jwp.1 uc292jwp.2 uc292jwp.3 uc292jwp.1 uc292jwp.2 uc292jwp.3 
ENSMUST00000061656.8 Rictor ENSMUST00000061656.8 RPTOR independent companion of MTOR, complex 2 (from RefSeq NM_030168.3) E9QPE0 ENSMUST00000061656.1 ENSMUST00000061656.2 ENSMUST00000061656.3 ENSMUST00000061656.4 ENSMUST00000061656.5 ENSMUST00000061656.6 ENSMUST00000061656.7 Kiaa1999 NM_030168 Q0VAV4 Q69Z40 Q6PDL2 Q6QI06 Q6RI74 Q8BPH9 Q8CBF2 RICTR_MOUSE Rictor uc007vdr.1 uc007vdr.2 uc007vdr.3 uc007vdr.4 uc007vdr.5 Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (PubMed:15467718, PubMed:16962829, PubMed:16962653). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12- rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex; interaction with MTOR is enhanced by deubiquitination of RICTOR by USP9X. Interaction with MAPKAP1 is not enhanced by RICTOR deubiquitination by USP9X (By similarity). Interacts with CCDC28B. Interacts with NBN. Interacts with PRR5L (By similarity). Interacts with SIK3 (By similarity). Interacts with NCKAP1L (By similarity). Interacts with FBXW7; the interaction results in RICTOR ubiquitination and degradation (By similarity). Interacts with USP9X; the interaction results in deubiquitination of RICTOR and protection from proteasomal degradation, thus promoting mTORC2 complex assembly (By similarity). Interacts with ARMH4 (via cytoplasmic tail); this interaction bridges ARMH4 to the mTORC2 complex and inhibits the mTORC2 kinase activity (PubMed:25418727). Interacts with UBXN2A (By similarity). Q6QI06; Q9JLN9: Mtor; NbExp=12; IntAct=EBI-4286572, EBI-1571628; Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q6QI06-1; Sequence=Displayed; Name=2 ; IsoId=Q6QI06-2; Sequence=VSP_052583; Highest levels in liver and brain with expression also detected in heart, muscle, spleen and kidney (at protein level). Phosphorylated by MTOR; when part of mTORC2 (By similarity). Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling (By similarity). Ubiquitinated by the SCF(FBXW7) complex, leading to its degradation by the proteasome (By similarity). Deubiquitinated by USP9X; deubiquitination stabilizes RICTOR and enhances its binding to MTOR, thus promoting mTORC2 complex assembly (By similarity). Mice develop normally until 9.5 dpc, and then display growth arrest and embryonic lethality by 11.5 dpc. Belongs to the RICTOR family. regulation of protein phosphorylation positive regulation of endothelial cell proliferation protein binding multicellular organism development enzyme activator activity embryo development ending in birth or egg hatching regulation of gene expression peptidyl-serine phosphorylation protein kinase binding establishment of cell polarity positive regulation of actin filament polymerization establishment or maintenance of actin cytoskeleton polarity actin cytoskeleton reorganization TOR signaling TORC2 complex positive regulation of TOR signaling regulation of actin cytoskeleton organization regulation of peptidyl-serine phosphorylation regulation of phosphorylation ribosome binding positive regulation of catalytic activity regulation of GTPase activity regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation regulation of protein kinase B signaling positive regulation of protein kinase B signaling regulation of establishment of cell polarity uc007vdr.1 uc007vdr.2 uc007vdr.3 uc007vdr.4 uc007vdr.5 
ENSMUST00000061673.9 Itga1 ENSMUST00000061673.9 integrin alpha 1 (from RefSeq NM_001033228.3) ENSMUST00000061673.1 ENSMUST00000061673.2 ENSMUST00000061673.3 ENSMUST00000061673.4 ENSMUST00000061673.5 ENSMUST00000061673.6 ENSMUST00000061673.7 ENSMUST00000061673.8 F8VQN5 ITA1_MOUSE NM_001033228 Q3V3R4 uc007rxx.1 uc007rxx.2 uc007rxx.3 uc007rxx.4 Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1 (By similarity). Interacts with RAB21 (By similarity). Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively regulates EGF signaling (By similarity). Membrane ; Single-pass type I membrane protein The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. Belongs to the integrin alpha chain family. activation of MAPK activity acrosomal vesicle receptor binding protein binding collagen binding plasma membrane focal adhesion cell adhesion cell-matrix adhesion integrin-mediated signaling pathway negative regulation of cell proliferation integrin complex external side of plasma membrane cell surface membrane integral component of membrane protein phosphatase binding neutrophil chemotaxis positive regulation of phosphoprotein phosphatase activity integrin alpha1-beta1 complex negative regulation of epidermal growth factor receptor signaling pathway vasodilation neuron projection perikaryon positive regulation of neuron apoptotic process membrane raft cellular extravasation basal part of cell metal ion binding neuron projection morphogenesis cell chemotaxis collagen binding involved in cell-matrix adhesion uc007rxx.1 uc007rxx.2 uc007rxx.3 uc007rxx.4 
ENSMUST00000061679.3 4921508M14Rik ENSMUST00000061679.3 4921508M14Rik (from geneSymbol) AK014845 ENSMUST00000061679.1 ENSMUST00000061679.2 uc288fxc.1 uc288fxc.2 uc288fxc.1 uc288fxc.2 
ENSMUST00000061688.11 Ermardl2 ENSMUST00000061688.11 ER membrane associated RNA degradation like 2 (from RefSeq NM_001123370.1) 9030025P20Rik E9Q764 ENSMUST00000061688.1 ENSMUST00000061688.10 ENSMUST00000061688.2 ENSMUST00000061688.3 ENSMUST00000061688.4 ENSMUST00000061688.5 ENSMUST00000061688.6 ENSMUST00000061688.7 ENSMUST00000061688.8 ENSMUST00000061688.9 Ermardl2 NM_001123370 Q8C5D3 Q8C5D3_MOUSE uc008ano.1 uc008ano.2 uc008ano.3 uc008ano.4 molecular_function cellular_component biological_process uc008ano.1 uc008ano.2 uc008ano.3 uc008ano.4 
ENSMUST00000061695.5 4930451I11Rik ENSMUST00000061695.5 RIKEN cDNA 4930451I11 gene (from RefSeq NM_183131.3) E9Q9R3 ENSMUST00000061695.1 ENSMUST00000061695.2 ENSMUST00000061695.3 ENSMUST00000061695.4 FIMP_MOUSE Fimp NM_183131 Q8CEL4 uc009jta.1 uc009jta.2 uc009jta.3 [Isoform 1]: Plays a role in sperm-oocyte fusion process during fertilization. [Isoform 1]: Cell membrane ; Single-pass type I membrane protein Note=Localized to the equatorial segment of the sperm head. [Isoform 2]: Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q9R3-1; Sequence=Displayed; Name=2; IsoId=E9Q9R3-2; Sequence=VSP_060728, VSP_060729; Testis-specific. Deficient mice have no overt developmental abnormalities. Furthermore, no deleterious effects on testicular histology and sperm morphology are observed. However male mice are severely subfertile, their spermatozoa show impaired ability to fuse with the oocytes. Sequence=AAH48622.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC25600.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc009jta.1 uc009jta.2 uc009jta.3 
ENSMUST00000061699.12 Bpifc ENSMUST00000061699.12 BPI fold containing family C (from RefSeq NM_177772.4) Bpifc Bpil2 ENSMUST00000061699.1 ENSMUST00000061699.10 ENSMUST00000061699.11 ENSMUST00000061699.2 ENSMUST00000061699.3 ENSMUST00000061699.4 ENSMUST00000061699.5 ENSMUST00000061699.6 ENSMUST00000061699.7 ENSMUST00000061699.8 ENSMUST00000061699.9 NM_177772 Q3V1D7 Q3V1D7_MOUSE uc007gnj.1 uc007gnj.2 uc007gnj.3 uc007gnj.4 The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Monomer. Homodimer; disulfide-linked. Secreted The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues. The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C- terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. extracellular space lipid binding uc007gnj.1 uc007gnj.2 uc007gnj.3 uc007gnj.4 
ENSMUST00000061706.7 E130311K13Rik ENSMUST00000061706.7 RIKEN cDNA E130311K13 gene, transcript variant 1 (from RefSeq NM_177856.6) CC033_MOUSE ENSMUST00000061706.1 ENSMUST00000061706.2 ENSMUST00000061706.3 ENSMUST00000061706.4 ENSMUST00000061706.5 ENSMUST00000061706.6 NM_177856 Q059W9 Q8BN57 uc008pkb.1 uc008pkb.2 uc008pkb.3 May play a role in transcription regulation. Membrane ; Single-pass membrane protein molecular_function extracellular space membrane integral component of membrane regulation of sequence-specific DNA binding transcription factor activity negative regulation of ERK1 and ERK2 cascade uc008pkb.1 uc008pkb.2 uc008pkb.3 
ENSMUST00000061717.4 Pcdhb6 ENSMUST00000061717.4 protocadherin beta 6 (from RefSeq NM_053131.2) ENSMUST00000061717.1 ENSMUST00000061717.2 ENSMUST00000061717.3 NM_053131 PCDB6_MOUSE Pcdhb6 Q91XZ4 uc008epr.1 uc008epr.2 uc008epr.3 Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (PubMed:27161523). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523). Forms homodimers in trans (molecules expressed by two different cells). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins. Cell membrane ; Single-pass type I membrane protein Cadherin 1 to cadherin 4 domains mediate homophilic trans- interaction, the interaction with an identical protocadherin expressed by a neighboring cell (PubMed:27161523). This is a head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin (PubMed:27161523). The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane (PubMed:27161523). Each cadherin domain binds three calcium ions (PubMed:27161523). calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cell-cell recognition membrane integral component of membrane identical protein binding metal ion binding uc008epr.1 uc008epr.2 uc008epr.3 
ENSMUST00000061721.6 E2f2 ENSMUST00000061721.6 E2F transcription factor 2, transcript variant 1 (from RefSeq NM_177733.7) A2AW43 E2F2_MOUSE ENSMUST00000061721.1 ENSMUST00000061721.2 ENSMUST00000061721.3 ENSMUST00000061721.4 ENSMUST00000061721.5 NM_177733 P56931 Q8BID0 uc008vht.1 uc008vht.2 uc008vht.3 uc008vht.4 uc008vht.5 uc008vht.6 Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F2 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Binds EAPP. Nucleus. Expressed in the developing epidermis and intestinal epithelium. First detected in the epidermis at stage 13.5- 14.5 dpc with higher levels in the head and thorax regions. At 15.5 dpc, expression is found in both the epithelium and, to a lesser extent in the underlying mesenchyme. At day 16.5 dpc, high expression in the basal cells. Later expression is found in the developing hair follicles, around the dermal papillae. In the developing intestinal epithelium, expression first observed around 14.5 dpc. Levels continue to increase at least until 19.5 dpc, with highest levels in the intervillus epithelium and in the bottom half of the villi. In the nervous system, first expressed at 9.5 dpc, in the forebrain. At 10.5 dpc, expressed broadly in the brain, and at lower levels in the upper regions of the spinal cord. By 11.5 dpc, E2F2 expression is found throughout the central nervous system and levels peak at 12.5-15.5 dpc. In the developing spinal cord, E2F2 expression found only in the dorsal region. In the developing retina, highest expression found in the 14.5- 18.5 dpc embryonic retinoblastic cell layer. In other developing tissues, E2F2 is found highest in thymus and liver, with lower expression in lung, heart, kidney and skeletal muscle. Also found in choroid plexus and chondrocytes. Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Belongs to the E2F/DP family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated cell cycle transcription factor binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter protein dimerization activity regulation of cell cycle intrinsic apoptotic signaling pathway by p53 class mediator RNA polymerase II transcription factor complex negative regulation of sprouting angiogenesis lens fiber cell apoptotic process uc008vht.1 uc008vht.2 uc008vht.3 uc008vht.4 uc008vht.5 uc008vht.6 
ENSMUST00000061723.6 Or6d15 ENSMUST00000061723.6 olfactory receptor family 6 subfamily D member 15 (from RefSeq NM_146446.1) ENSMUST00000061723.1 ENSMUST00000061723.2 ENSMUST00000061723.3 ENSMUST00000061723.4 ENSMUST00000061723.5 NM_146446 Olfr215 Or6d15 Q8VF82 Q8VF82_MOUSE uc009dki.1 uc009dki.2 uc009dki.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009dki.1 uc009dki.2 uc009dki.3 
ENSMUST00000061725.8 Prss32 ENSMUST00000061725.8 serine protease 32 (from RefSeq NM_027220.2) E9Q409 E9Q409_MOUSE ENSMUST00000061725.1 ENSMUST00000061725.2 ENSMUST00000061725.3 ENSMUST00000061725.4 ENSMUST00000061725.5 ENSMUST00000061725.6 ENSMUST00000061725.7 NM_027220 Prss32 uc012ama.1 uc012ama.2 uc012ama.3 serine-type endopeptidase activity extracellular space plasma membrane proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc012ama.1 uc012ama.2 uc012ama.3 
ENSMUST00000061728.5 Nog ENSMUST00000061728.5 noggin (from RefSeq NM_008711.2) ENSMUST00000061728.1 ENSMUST00000061728.2 ENSMUST00000061728.3 ENSMUST00000061728.4 NM_008711 NOGG_MOUSE P97466 uc007kwh.1 uc007kwh.2 uc007kwh.3 uc007kwh.4 Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (PubMed:9585504, PubMed:9603738). Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity). Homodimer. Interacts with GDF5; inhibits chondrocyte differentiation. Secreted. Expressed in condensing cartilage and immature chondrocytes. Embryonic expression was first detected in the node at 7.5 dpc. By early somite stages, expression extends anteriorly along the entire length of the notochord and is expressed in the dorsal neural tube from the caudal hindbrain to the posterior-most region of the embryo. By the time cranial tube closure is completed expression is continuous along most of the dorsal midline of the neural tube, to its rostral termination at the base of the forebrain. Expression in the neural tube and caudal notochord remains unchanged during early organogenesis from 9.5 dpc to 10.5 dpc. Defects in Nog are the cause of a recessive lethal phenotype at birth. Multiple defects include a failure of neural tube closure, broad club-shaped limbs, loss of caudal vertebrae, a shortened body axis, and retention of a small vestigial tail. Belongs to the noggin family. negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast differentiation urogenital system development ureteric bud development in utero embryonic development endoderm formation mesoderm formation epithelial to mesenchymal transition neural plate morphogenesis neural tube closure membranous septum morphogenesis outflow tract morphogenesis endocardial cushion morphogenesis ventricular compact myocardium morphogenesis extracellular region extracellular space multicellular organism development pattern specification process axon guidance central nervous system development brain development endoderm development memory motor neuron axon guidance positive regulation of cell proliferation visual learning dorsal/ventral pattern formation positive regulation of gene expression negative regulation of gene expression cytokine binding spinal cord development cell differentiation in hindbrain neural tube development pituitary gland development cell differentiation negative regulation of cell migration axon regulation of BMP signaling pathway negative regulation of BMP signaling pathway macromolecular complex somatic stem cell population maintenance wound healing middle ear morphogenesis embryonic digit morphogenesis protein homodimerization activity macromolecular complex binding negative regulation of cell differentiation negative regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter axial mesoderm development notochord morphogenesis anatomical structure formation involved in morphogenesis embryonic skeletal system development negative regulation of astrocyte differentiation mesenchymal cell differentiation positive regulation of epithelial cell proliferation cartilage development atrial cardiac muscle tissue morphogenesis negative regulation of cardiac muscle cell proliferation limb development embryonic skeletal joint morphogenesis negative regulation of cytokine activity face morphogenesis negative regulation of pathway-restricted SMAD protein phosphorylation ventricular septum morphogenesis lung morphogenesis prostatic bud formation ureteric bud formation fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation negative regulation of cartilage development somite development BMP signaling pathway involved in heart development heart trabecula morphogenesis pharyngeal arch artery morphogenesis positive regulation of oligodendrocyte progenitor proliferation cellular response to BMP stimulus negative regulation of canonical Wnt signaling pathway positive regulation of branching involved in ureteric bud morphogenesis positive regulation of glomerulus development negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation negative regulation of apoptotic signaling pathway uc007kwh.1 uc007kwh.2 uc007kwh.3 uc007kwh.4 
ENSMUST00000061739.9 Pcp4 ENSMUST00000061739.9 Purkinje cell protein 4 (from RefSeq NM_008791.3) ENSMUST00000061739.1 ENSMUST00000061739.2 ENSMUST00000061739.3 ENSMUST00000061739.4 ENSMUST00000061739.5 ENSMUST00000061739.6 ENSMUST00000061739.7 ENSMUST00000061739.8 NM_008791 P07734 P63054 PCP4_MOUSE Pcp4 Pep19 Q63890 uc008adc.1 uc008adc.2 uc008adc.3 uc008adc.4 Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways. Binds to both calcium-free and calcium-bound calmodulin. The affinity for the calcium-bound form is 50-fold greater. Mostly intrinsically disordered, with residual structure localized to the IQ domain which mediates the interaction with calmodulin. Belongs to the PCP4 family. RNA binding calcium ion binding calmodulin binding cytoplasm neurofilament negative regulation of protein kinase activity positive regulation of neuron projection development axon macromolecular complex positive regulation of dopamine secretion neuron projection negative regulation of neuron apoptotic process positive regulation of neuron differentiation calmodulin dependent kinase signaling pathway uc008adc.1 uc008adc.2 uc008adc.3 uc008adc.4 
ENSMUST00000061745.5 Hoxd10 ENSMUST00000061745.5 homeobox D10 (from RefSeq NM_013554.5) ENSMUST00000061745.1 ENSMUST00000061745.2 ENSMUST00000061745.3 ENSMUST00000061745.4 HXD10_MOUSE Hox-4.5 Hoxd-10 NM_013554 P28359 Q91WU9 uc008kdx.1 uc008kdx.2 uc008kdx.3 uc008kdx.4 uc008kdx.5 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. P28359; O88513: Gmnn; NbExp=2; IntAct=EBI-445929, EBI-445922; P28359; P70323: Tbx1; NbExp=3; IntAct=EBI-445929, EBI-13635846; Nucleus. Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the second or third lumbar pre-vertebrae. Belongs to the Abd-B homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated multicellular organism development single fertilization skeletal muscle tissue development adult locomotory behavior anterior/posterior pattern specification proximal/distal pattern formation regulation of gene expression spinal cord motor neuron cell fate specification embryonic limb morphogenesis forelimb morphogenesis hindlimb morphogenesis cytoplasmic ribonucleoprotein granule sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system morphogenesis peripheral nervous system neuron development neuromuscular process uc008kdx.1 uc008kdx.2 uc008kdx.3 uc008kdx.4 uc008kdx.5 
ENSMUST00000061767.5 Crebzf ENSMUST00000061767.5 CREB/ATF bZIP transcription factor, transcript variant 1 (from RefSeq NM_145151.3) ENSMUST00000061767.1 ENSMUST00000061767.2 ENSMUST00000061767.3 ENSMUST00000061767.4 NM_145151 Q91Y72 Q91ZR3 ZHANG_MOUSE Zf uc009ihl.1 uc009ihl.2 uc009ihl.3 uc009ihl.4 Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells (By similarity). Interacts with HCFC1; the interaction inhibits CREB3 transcriptional activity. Interacts with CREB3; the interaction occurs only in combination with HCFC1. Q91ZR3; P62509: Esrrg; NbExp=3; IntAct=EBI-5274001, EBI-5274019; Nucleus Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML- NB) with CREB3 and HCFC1. Belongs to the bZIP family. ATF subfamily. Sequence=AAK51608.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence derived from chromosome 13 in the N-terminal part.; Evidence=; Sequence=AAL04512.1; Type=Erroneous initiation; Evidence=; transcription factor activity, sequence-specific DNA binding protein binding nucleus mitochondrion transcription, DNA-templated regulation of transcription, DNA-templated response to virus identical protein binding negative regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated regulation of sequence-specific DNA binding transcription factor activity uc009ihl.1 uc009ihl.2 uc009ihl.3 uc009ihl.4 
ENSMUST00000061772.11 Rbm15 ENSMUST00000061772.11 RNA binding motif protein 15 (from RefSeq NM_001045807.2) A0PJG5 ENSMUST00000061772.1 ENSMUST00000061772.10 ENSMUST00000061772.2 ENSMUST00000061772.3 ENSMUST00000061772.4 ENSMUST00000061772.5 ENSMUST00000061772.6 ENSMUST00000061772.7 ENSMUST00000061772.8 ENSMUST00000061772.9 Kiaa4257 NM_001045807 Ott1 Q0VBL3 Q3THK4 Q3TLX0 Q571M7 Q66JP8 Q6PGG1 Q7TT82 RBM15_MOUSE Rbm15 uc008qwz.1 uc008qwz.2 uc008qwz.3 RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:29535189). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:29535189). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (By similarity). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (PubMed:17283045, PubMed:17376872, PubMed:18981216, PubMed:25468569). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (By similarity). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (PubMed:18981216). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (PubMed:25468569). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (By similarity). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing- mediated NXF1 deposition, resulting in export prior to splicing (By similarity). May be implicated in HOX gene regulation (By similarity). Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:29535189). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:29535189). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29535189). Also a component of a MACOM- like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (By similarity). Interacts with RBPJ (PubMed:17283045). Interacts (via SPOC domain) with SETD1B (By similarity). Interacts with NXF1, the interaction is required to promote mRNA export (By similarity). Interacts with SF3B1 (By similarity). Nucleus speckle Nucleus, nucleoplasm Nucleus envelope Nucleus membrane ; Peripheral membrane protein Note=Colocalizes at the nuclear pore with DBP5 and NXF1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0VBL3-1; Sequence=Displayed; Name=2; IsoId=Q0VBL3-2; Sequence=VSP_059625; Methylated at Arg-577 by PRMT1, leading to promote ubiquitination by CNOT4 and subsequent degradation by the proteasome. Ubiquitinated by CNOT4 following methylation at Arg-577 by PRMT1. Embryonic lethality around E9.5 (PubMed:17376872, PubMed:18981216). Early embryos show growth retardation and incomplete closure of the notochord, as well as placental defects in the spongiotrophoblast and syncytiotrophoblast layers, resulting in an arrest of vascular branching morphogenesis (PubMed:18981216). Conditional knockout mice lacking Rbm15 within the hematopoietic compartment display a loss of peripheral B-cells due to a block in pro/pre-B differentiation, as well as a myeloid and megakaryocytic expansion in spleen and bone marrow (PubMed:17376872). Belongs to the RRM Spen family. Sequence=AAH80828.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence=; Sequence=BAD90348.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter regulation of alternative mRNA splicing, via spliceosome RNA methylation branching involved in blood vessel morphogenesis nucleic acid binding RNA binding mRNA binding protein binding nucleus nuclear envelope nucleoplasm positive regulation of transcription of Notch receptor target dosage compensation by inactivation of X chromosome membrane nuclear speck nuclear membrane MIS complex thrombopoietin-mediated signaling pathway negative regulation of myeloid cell differentiation regulation of megakaryocyte differentiation spleen development ventricular septum morphogenesis placenta blood vessel development uc008qwz.1 uc008qwz.2 uc008qwz.3 
ENSMUST00000061786.6 Tmem220 ENSMUST00000061786.6 transmembrane protein 220, transcript variant 3 (from RefSeq NM_001291043.1) ENSMUST00000061786.1 ENSMUST00000061786.2 ENSMUST00000061786.3 ENSMUST00000061786.4 ENSMUST00000061786.5 NM_001291043 Q2TB06 Q8BP07 Q8C936 TM220_MOUSE uc007jlr.1 uc007jlr.2 uc007jlr.3 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BP07-1; Sequence=Displayed; Name=2; IsoId=Q8BP07-2; Sequence=VSP_031478; Name=3; IsoId=Q8BP07-3; Sequence=VSP_031479, VSP_031480; molecular_function cellular_component biological_process membrane integral component of membrane uc007jlr.1 uc007jlr.2 uc007jlr.3 
ENSMUST00000061789.14 Nyap1 ENSMUST00000061789.14 neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1, transcript variant 1 (from RefSeq NM_175521.4) E1CB66 ENSMUST00000061789.1 ENSMUST00000061789.10 ENSMUST00000061789.11 ENSMUST00000061789.12 ENSMUST00000061789.13 ENSMUST00000061789.2 ENSMUST00000061789.3 ENSMUST00000061789.4 ENSMUST00000061789.5 ENSMUST00000061789.6 ENSMUST00000061789.7 ENSMUST00000061789.8 ENSMUST00000061789.9 NM_175521 NYAP1_MOUSE Q3UF51 Q6PFX7 Q8BNR4 Q8CCL6 uc291ayo.1 uc291ayo.2 Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling. Q6PFX7; P27986: PIK3R1; Xeno; NbExp=4; IntAct=EBI-7447489, EBI-79464; Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PFX7-1; Sequence=Displayed; Name=2; IsoId=Q6PFX7-2; Sequence=VSP_031748; Name=3; IsoId=Q6PFX7-3; Sequence=VSP_031747, VSP_031748; Expressed predominantly in brain where it is present in the neurons, but not in astrocytes or oligodendrites. Expression first detected in the cortical plate as early as 14 dpc, peaks in the middle neocortex at postnatal day 1 and then gradually decreases. At postnatal day 1, also expressed in the striatum, but not in the olfactory bulb. Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5. Phosphorylation begins at 14 dpc, reaches a peak during perinatal days in brain, then gradually decreases. Triple knockout mice NYAP1/NYAP2/MYO16 are fertile and appear healthy. However, compared to wild-type mice they show a clear reduction in brain size, exhibiting a reduction in the size of the cortex and striatum, but not the olfactory bulb or corpus callosum. The total neurite length of neurons in these mice is also significantly shorter. Belongs to the NYAP family. Sequence=BAC38036.1; Type=Frameshift; Evidence=; protein binding phosphatidylinositol 3-kinase signaling neuron projection morphogenesis uc291ayo.1 uc291ayo.2 
ENSMUST00000061796.8 Gpr6 ENSMUST00000061796.8 G protein-coupled receptor 6 (from RefSeq NM_199058.2) ENSMUST00000061796.1 ENSMUST00000061796.2 ENSMUST00000061796.3 ENSMUST00000061796.4 ENSMUST00000061796.5 ENSMUST00000061796.6 ENSMUST00000061796.7 GPR6_MOUSE Gm233 NM_199058 Q6YNI2 uc007exj.1 uc007exj.2 uc007exj.3 Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Cell membrane ; Multi-pass membrane protein Note=Highly expressed and localized along the cytoplasmic membrane as well as in a perinuclear compartment. Mainly expressed in the brain. Selectively expressed in striatopallidal neurons in the striatum. Deficient mice show reduced striatal cyclic AMP production and selective alterations in instrumental conditioning. Belongs to the G-protein coupled receptor 1 family. Was originally (PubMed:14592418) thought to be a receptor for sphingosine 1-phosphate. It has been demonstrated that it is not the case in human. sphingosine-1-phosphate signaling pathway G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane sphingosine-1-phosphate receptor activity uc007exj.1 uc007exj.2 uc007exj.3 
ENSMUST00000061799.10 Loxl1 ENSMUST00000061799.10 lysyl oxidase-like 1 (from RefSeq NM_010729.3) A0A0R4J0Q4 A0A0R4J0Q4_MOUSE ENSMUST00000061799.1 ENSMUST00000061799.2 ENSMUST00000061799.3 ENSMUST00000061799.4 ENSMUST00000061799.5 ENSMUST00000061799.6 ENSMUST00000061799.7 ENSMUST00000061799.8 ENSMUST00000061799.9 Loxl1 NM_010729 uc009pwv.1 uc009pwv.2 uc009pwv.3 uc009pwv.4 This gene encodes a member of the lysyl oxidase family of copper-dependent enzymes that catalyze the formation of lysine-derived crosslinks in proteins such as collagen and elastin. The encoded preproprotein undergoes proteolytic processing to generate the mature, functional enzyme. Mice lacking the encoded protein fail to deposit normal elastic fibers in the uterine tract post partum and develop pelvic organ prolapse, enlarged airspaces of the lung, loose skin and vascular abnormalities with concomitant tropoelastin accumulation. [provided by RefSeq, Sep 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC037999.1, AF357006.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Belongs to the lysyl oxidase family. acrosomal vesicle copper ion binding basement membrane cytoplasm oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor extracellular matrix response to lipopolysaccharide aorta development oxidation-reduction process uc009pwv.1 uc009pwv.2 uc009pwv.3 uc009pwv.4 
ENSMUST00000061826.3 B3galnt1 ENSMUST00000061826.3 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1, transcript variant 1 (from RefSeq NM_020026.5) B3GL1_MOUSE B3galnt1 B3galt3 B3gt3 ENSMUST00000061826.1 ENSMUST00000061826.2 Mbrn1 NM_020026 O54906 Q91V72 Q920V0 Q920V1 Q9CTE5 uc008pmj.1 uc008pmj.2 uc008pmj.3 uc008pmj.4 Transfers N-acetylgalactosamine onto globotriaosylceramide (PubMed:9417047). Plays a critical role in preimplantation stage embryonic development (PubMed:11463849). Reaction=a globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D- galactosamine = a globoside Gb4Cer (d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:22252, ChEBI:CHEBI:15378, ChEBI:CHEBI:18259, ChEBI:CHEBI:18313, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.79; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22253; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein Detected in brain, ovary, kidney, uterus and stomach (PubMed:9417047, PubMed:11463849). In ovary, specifically expressed in follicular granulosa cells and shows particularly strong expression at later stages of follicle development (PubMed:11463849). Detected in embryos from 12.5 days post coitum (dpc) onwards. Expressed in all four ventricles of the developing brain, with highest expression in the outer ventricular layer. Also found in the limb buds at 12.5 dpc. Detected in the brain (hippocampus) and retina at postnatal day 1. Expression in the retina is localized to the ganglion cell layer. At postnatal day 10, expression remains strong in the hippocampus where it localizes to the four CA fields and the dentate gyrus. Embryonic lethal. Lethality occurs at the preimplantation stage, between 3.5 and 4.5 days post-coitum (dpc). Belongs to the glycosyltransferase 31 family. Name=Functional Glycomics Gateway - GTase; Note=b3GalT3; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_456"; Golgi membrane endoplasmic reticulum Golgi apparatus protein glycosylation protein N-linked glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity oligosaccharide biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity uc008pmj.1 uc008pmj.2 uc008pmj.3 uc008pmj.4 
ENSMUST00000061828.10 Kcng4 ENSMUST00000061828.10 potassium voltage-gated channel, subfamily G, member 4, transcript variant 1 (from RefSeq NM_025734.2) ENSMUST00000061828.1 ENSMUST00000061828.2 ENSMUST00000061828.3 ENSMUST00000061828.4 ENSMUST00000061828.5 ENSMUST00000061828.6 ENSMUST00000061828.7 ENSMUST00000061828.8 ENSMUST00000061828.9 KCNG4_MOUSE NM_025734 Q80XM3 uc009nqb.1 uc009nqb.2 Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Heterotetramer with KCNB1. Cell membrane ; Multi-pass membrane protein Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Colocalizes with KCNB1 at the plasma membrane. Remains intracellular in the absence of KCNB1. The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane regulation of ion transmembrane transport ion channel binding protein homooligomerization transmembrane transport potassium ion transmembrane transport uc009nqb.1 uc009nqb.2 
ENSMUST00000061829.8 Cd14 ENSMUST00000061829.8 CD14 antigen (from RefSeq NM_009841.4) Cd14 ENSMUST00000061829.1 ENSMUST00000061829.2 ENSMUST00000061829.3 ENSMUST00000061829.4 ENSMUST00000061829.5 ENSMUST00000061829.6 ENSMUST00000061829.7 NM_009841 Q4FJP7 Q4FJP7_MOUSE uc008eof.1 uc008eof.2 uc008eof.3 uc008eof.4 uc008eof.5 This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. [provided by RefSeq, Jul 2014]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149744.1, BC057889.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-). Belongs to the lipopolysaccharide (LPS) receptor, a multi- protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1. Cell membrane ; Lipid-anchor, GPI-anchor Golgi apparatus Membrane raft Membrane ; Lipid-anchor, GPI-anchor lipopolysaccharide binding immune system process extracellular space Golgi apparatus plasma membrane inflammatory response response to heat cell surface membrane anchored component of external side of plasma membrane response to magnesium ion response to lipopolysaccharide positive regulation of tumor necrosis factor production response to tumor necrosis factor innate immune response membrane raft response to ethanol lipopolysaccharide receptor complex positive regulation of cytokine secretion response to electrical stimulus lipoteichoic acid binding cellular response to molecule of bacterial origin cellular response to lipopolysaccharide cellular response to lipoteichoic acid lipopeptide binding cellular response to diacyl bacterial lipopeptide cellular response to triacyl bacterial lipopeptide positive regulation of NIK/NF-kappaB signaling positive regulation of interleukin-8 secretion uc008eof.1 uc008eof.2 uc008eof.3 uc008eof.4 uc008eof.5 
ENSMUST00000061833.6 Tlcd5 ENSMUST00000061833.6 TLC domain containing 5, transcript variant 2 (from RefSeq NR_153341.1) B9EI43 ENSMUST00000061833.1 ENSMUST00000061833.2 ENSMUST00000061833.3 ENSMUST00000061833.4 ENSMUST00000061833.5 Gm184 NR_153341 Q3TYE7 TLCD5_MOUSE Tmem136 uc009pbd.1 uc009pbd.2 uc009pbd.3 Membrane ; Multi-pass membrane protein Belongs to the TLCD5 family. molecular_function cellular_component biological_process membrane integral component of membrane uc009pbd.1 uc009pbd.2 uc009pbd.3 
ENSMUST00000061835.10 Vsig8 ENSMUST00000061835.10 V-set and immunoglobulin domain containing 8, transcript variant 1 (from RefSeq NM_177723.4) ENSMUST00000061835.1 ENSMUST00000061835.2 ENSMUST00000061835.3 ENSMUST00000061835.4 ENSMUST00000061835.5 ENSMUST00000061835.6 ENSMUST00000061835.7 ENSMUST00000061835.8 ENSMUST00000061835.9 NM_177723 Q6P3A4 VSIG8_MOUSE uc007dqs.1 uc007dqs.2 uc007dqs.3 Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P3A4-1; Sequence=Displayed; Name=2; IsoId=Q6P3A4-2; Sequence=VSP_030071; biological_process membrane integral component of membrane uc007dqs.1 uc007dqs.2 uc007dqs.3 
ENSMUST00000061837.11 Neurl4 ENSMUST00000061837.11 neuralized E3 ubiquitin protein ligase 4, transcript variant 1 (from RefSeq NM_001013414.4) ENSMUST00000061837.1 ENSMUST00000061837.10 ENSMUST00000061837.2 ENSMUST00000061837.3 ENSMUST00000061837.4 ENSMUST00000061837.5 ENSMUST00000061837.6 ENSMUST00000061837.7 ENSMUST00000061837.8 ENSMUST00000061837.9 Kiaa1787 NEUL4_MOUSE NM_001013414 Q3U090 Q5NCX4 Q5NCX5 Q69ZA2 Q8R1V5 uc007jsn.1 uc007jsn.2 uc007jsn.3 uc007jsn.4 uc007jsn.5 Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers (By similarity). Interacts with CCP110; this interaction propmotes CCP110 ubiquitination and degradation via the proteasome pathway. Via its interaction with CCP110, may indirectly interact with CEP97. Interacts with the E3 ubiquitin-protein ligase HERC2 and UBE3A. May interact with MAPK6 and hence mediate MAPK6 interaction with UBE3A. Interaction with UBE3A may be indirect and mediated by HERC2 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5NCX5-1; Sequence=Displayed; Name=2; IsoId=Q5NCX5-2; Sequence=VSP_027564; Ubiquitinated; undergoes HERC2-dependent 'Lys-48' ubiquitination. This ubiquitination leads to proteasomal degradation (By similarity). Sequence=CAI35150.1; Type=Erroneous gene model prediction; Evidence=; cellular_component cytoplasm centriole cytoskeleton protein ubiquitination ubiquitin protein ligase activity uc007jsn.1 uc007jsn.2 uc007jsn.3 uc007jsn.4 uc007jsn.5 
ENSMUST00000061850.5 Pomk ENSMUST00000061850.5 protein-O-mannose kinase (from RefSeq NM_029037.4) ENSMUST00000061850.1 ENSMUST00000061850.2 ENSMUST00000061850.3 ENSMUST00000061850.4 NM_029037 Q3TBZ0 Q3TUA9 Q8BZ83 Q8R2S2 Q9D5G4 SG196_MOUSE Sgk196 uc009lhh.1 uc009lhh.2 uc009lhh.3 Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)- beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4- (phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O- mannose, suggesting that this disaccharide serves as the substrate recognition motif (By similarity). Reaction=3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L- Thr-[protein] + ATP = 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)- (O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+); Xref=Rhea:RHEA:52616, Rhea:RHEA-COMP:13308, Rhea:RHEA-COMP:13309, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:136709, ChEBI:CHEBI:136710, ChEBI:CHEBI:456216; EC=2.7.1.183; Endoplasmic reticulum membrane ; Single-pass type II membrane protein Hydrocephaly: mutant mice exhibit dome-shaped heads of varying severity. Surviving mutant mice display numerous behavioral abnormalities: tremors, and inverted screen testing show 5 of 8 falling off, suggesting impaired motor strength. Impaired sensorimotor gating/attention is suggested by decreased prepulse inhibition, and impaired learning/memory is detected with trace aversive conditioning testing. In testing nociception, decreased paw flinching is observed during both formalin phases, suggesting decreased sensitivity to acute and tonic pain. Histologically, the most obvious changes are hydrocephalus in 4 of 5 and cerebellar dysplasia in all 5. Abnormalities in neuronal migration are evident in other parts of the brain; in the cerebral cortex, there is disorganization of cortical neuron layers, and the dentate gyrus of the hippocampus has a scalloped appearance. The cerebellar dysplasia is characterized by multifocal disorganization of cerebellar cortical neurons, with clusters of external granular neurons being scattered on the surface of the cerebellum and multifocally within the molecular layer of the cerebellum. In some regions, there is incomplete separation of cerebellar folia, and Purkinje cell. neurons were occasionally found in the molecular layer. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily. Although related to the Ser/Thr protein kinase family, has no protein kinase activity and acts as a mannose kinase instead. nucleotide binding neuron migration protein kinase activity ATP binding endoplasmic reticulum endoplasmic reticulum membrane protein phosphorylation protein O-linked glycosylation brain development learning or memory membrane integral component of membrane kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor carbohydrate kinase activity sensory perception of pain carbohydrate phosphorylation neuromuscular process uc009lhh.1 uc009lhh.2 uc009lhh.3 
ENSMUST00000061852.12 Dclre1c ENSMUST00000061852.12 DNA cross-link repair 1C, transcript variant 2 (from RefSeq NM_175683.4) A2AJG6 A2AJG7 A2AJG8 Art DCR1C_MOUSE ENSMUST00000061852.1 ENSMUST00000061852.10 ENSMUST00000061852.11 ENSMUST00000061852.2 ENSMUST00000061852.3 ENSMUST00000061852.4 ENSMUST00000061852.5 ENSMUST00000061852.6 ENSMUST00000061852.7 ENSMUST00000061852.8 ENSMUST00000061852.9 NM_175683 Q8BG72 Q8BTT1 Q8K4J0 Snm1l uc057lbh.1 uc057lbh.2 uc057lbh.3 This gene encodes a member of the SNM1 family of nucleases and is involved in V(D)J recombination and DNA repair. This protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Homozygous knockout mice for this gene exhibit severe combined immunodeficiency with sensitivity to ionizing radiation. Mutations in this gene in humans can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]. Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein likely exhibits single-strand specific 5'-3' exonuclease activity in isolation, and may acquire endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity may be required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ. Interacts with LIG4; the interaction is direct. Interacts with ATM. Interacts with BRCA1. Interacts with PRKDC. Interacts with TP53BP1. Also exhibits ATM- and phosphorylation-dependent interaction with the MRN complex, composed of MRE11, RAD50, and NBN. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K4J0-1; Sequence=Displayed; Name=2; IsoId=Q8K4J0-2; Sequence=VSP_014895, VSP_014896; Name=3; IsoId=Q8K4J0-3; Sequence=VSP_014893, VSP_014894, VSP_014895, VSP_014896; Phosphorylation on undefined residues by PRKDC may stimulate endonucleolytic activity on 5' and 3' hairpins and overhangs. PRKDC must remain present, even after phosphorylation, for efficient hairpin opening. Also phosphorylated by ATM in response to ionizing radiation (IR) and by ATR in response to ultraviolet (UV) radiation (By similarity). [Isoform 2]: May be due to an intron retention. Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family. single-stranded DNA endodeoxyribonuclease activity telomere maintenance nuclear chromosome, telomeric region adaptive immune response immune system process damaged DNA binding nuclease activity endonuclease activity exonuclease activity nucleus nucleoplasm Golgi apparatus DNA repair double-strand break repair double-strand break repair via nonhomologous end joining DNA recombination cellular response to DNA damage stimulus 5'-3' exonuclease activity response to ionizing radiation hydrolase activity B cell differentiation protection from non-homologous end joining at telomere V(D)J recombination 5'-3' exodeoxyribonuclease activity interstrand cross-link repair chromosome organization nonhomologous end joining complex nucleic acid phosphodiester bond hydrolysis uc057lbh.1 uc057lbh.2 uc057lbh.3 
ENSMUST00000061859.7 D17H6S53E ENSMUST00000061859.7 DNA segment, Chr 17, human D6S53E (from RefSeq NM_033477.2) CF047_MOUSE D17h6s53e ENSMUST00000061859.1 ENSMUST00000061859.2 ENSMUST00000061859.3 ENSMUST00000061859.4 ENSMUST00000061859.5 ENSMUST00000061859.6 NM_033477 Q9Z1R4 uc008cfz.1 uc008cfz.2 uc008cfz.3 uc008cfz.4 molecular_function cytosol biological_process uc008cfz.1 uc008cfz.2 uc008cfz.3 uc008cfz.4 
ENSMUST00000061866.6 Dnajb8 ENSMUST00000061866.6 DnaJ heat shock protein family (Hsp40) member B8 (from RefSeq NM_019964.1) DNJB8_MOUSE ENSMUST00000061866.1 ENSMUST00000061866.2 ENSMUST00000061866.3 ENSMUST00000061866.4 ENSMUST00000061866.5 NM_019964 Q9QYI7 uc009cve.1 uc009cve.2 uc009cve.3 Efficient suppressor of aggregation and toxicity of disease- associated polyglutamine proteins. Interacts with histone deacetylases HDAC4, HDAC6, and SIRT2, HDAC activity is required for antiaggregation. The antiaggregation activity resides in the serine-rich region and the C-terminus. nucleus cytosol protein binding involved in protein folding unfolded protein binding chaperone binding chaperone-mediated protein folding negative regulation of inclusion body assembly uc009cve.1 uc009cve.2 uc009cve.3 
ENSMUST00000061875.8 Zfp622 ENSMUST00000061875.8 zinc finger protein 622 (from RefSeq NM_144523.3) D15Ertd806e ENSMUST00000061875.1 ENSMUST00000061875.2 ENSMUST00000061875.3 ENSMUST00000061875.4 ENSMUST00000061875.5 ENSMUST00000061875.6 ENSMUST00000061875.7 NM_144523 Q91VY9 ZN622_MOUSE Znf622 uc007vjk.1 uc007vjk.2 uc007vjk.3 Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. Homo- and heterodimer. Associates with pre-60S ribosomal particles. Interacts with MELK and MYBL2. Interacts with DNAJC21. Cytoplasm Nucleus Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus. Ubiquitinated by HECTD1, leading to its degradation. Belongs to the REI1 family. nucleic acid binding nucleus nucleolus cytoplasm Golgi apparatus cytosol zinc ion binding intrinsic apoptotic signaling pathway in response to oxidative stress preribosome, large subunit precursor positive regulation of kinase activity ribosomal large subunit biogenesis positive regulation of apoptotic process positive regulation of MAPK cascade positive regulation of JNK cascade metal ion binding uc007vjk.1 uc007vjk.2 uc007vjk.3 
ENSMUST00000061878.5 Klhdc9 ENSMUST00000061878.5 kelch domain containing 9 (from RefSeq NM_001033039.2) ENSMUST00000061878.1 ENSMUST00000061878.2 ENSMUST00000061878.3 ENSMUST00000061878.4 KLDC9_MOUSE NM_001033039 Q3USL1 Q8BVR4 uc007dod.1 uc007dod.2 uc007dod.3 Interacts with CCNA1. cellular_component biological_process cyclin binding uc007dod.1 uc007dod.2 uc007dod.3 
ENSMUST00000061882.10 Mcat ENSMUST00000061882.10 malonyl CoA:ACP acyltransferase (mitochondrial), transcript variant 1 (from RefSeq NM_001030014.3) ENSMUST00000061882.1 ENSMUST00000061882.2 ENSMUST00000061882.3 ENSMUST00000061882.4 ENSMUST00000061882.5 ENSMUST00000061882.6 ENSMUST00000061882.7 ENSMUST00000061882.8 ENSMUST00000061882.9 FABD_MOUSE Mcat Mt NM_001030014 Q4FZH0 Q8R3F5 uc007xbf.1 uc007xbf.2 uc007xbf.3 Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria. Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]; Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449; EC=2.3.1.39; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41793; Evidence=; Lipid metabolism; fatty acid biosynthesis. Mitochondrion Belongs to the type II malonyltransferase family. Sequence=AAH25519.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; fatty acid synthase activity [acyl-carrier-protein] S-malonyltransferase activity mitochondrion lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process S-malonyltransferase activity transferase activity uc007xbf.1 uc007xbf.2 uc007xbf.3 
ENSMUST00000061890.8 Zfp282 ENSMUST00000061890.8 zinc finger protein 282 (from RefSeq NM_146175.3) E9PVC2 E9PVC2_MOUSE ENSMUST00000061890.1 ENSMUST00000061890.2 ENSMUST00000061890.3 ENSMUST00000061890.4 ENSMUST00000061890.5 ENSMUST00000061890.6 ENSMUST00000061890.7 NM_146175 Zfp282 uc009btl.1 uc009btl.2 uc009btl.3 uc009btl.4 molecular_function nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc009btl.1 uc009btl.2 uc009btl.3 uc009btl.4 
ENSMUST00000061891.11 Shld1 ENSMUST00000061891.11 shieldin complex subunit 1, transcript variant 1 (from RefSeq NM_001358260.2) A2AW53 ENSMUST00000061891.1 ENSMUST00000061891.10 ENSMUST00000061891.2 ENSMUST00000061891.3 ENSMUST00000061891.4 ENSMUST00000061891.5 ENSMUST00000061891.6 ENSMUST00000061891.7 ENSMUST00000061891.8 ENSMUST00000061891.9 NM_001358260 Q9D112 RINN3 SHLD1_MOUSE Shld1 uc008mne.1 uc008mne.2 uc008mne.3 uc008mne.4 Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. Component of the shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and MAD2L2/REV7. Within the complex, SHLD2 forms a scaffold which interacts with a SHLD3-MAD2L2 subcomplex via its N-terminus, and with SHLD1 via its C-terminus. Chromosome molecular_function chromosome DNA repair cellular response to DNA damage stimulus site of double-strand break positive regulation of isotype switching negative regulation of double-strand break repair via homologous recombination regulation of double-strand break repair via nonhomologous end joining positive regulation of double-strand break repair via nonhomologous end joining uc008mne.1 uc008mne.2 uc008mne.3 uc008mne.4 
ENSMUST00000061899.6 4931429P17Rik ENSMUST00000061899.6 RIKEN cDNA 4931429P17 gene (from RefSeq NR_038004.1) ENSMUST00000061899.1 ENSMUST00000061899.2 ENSMUST00000061899.3 ENSMUST00000061899.4 ENSMUST00000061899.5 NR_038004 uc029rzz.1 uc029rzz.2 uc029rzz.1 uc029rzz.2 
ENSMUST00000061923.5 Rln3 ENSMUST00000061923.5 relaxin 3 (from RefSeq NM_173184.1) ENSMUST00000061923.1 ENSMUST00000061923.2 ENSMUST00000061923.3 ENSMUST00000061923.4 Insl7 NM_173184 Q8CHK2 REL3_MOUSE uc009mls.1 uc009mls.2 uc009mls.3 May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity). Heterodimer of a B chain and an A chain linked by two disulfide bonds. Secreted. High expression in the brain localized to the pons/medulla with highest levels in pars ventromedialis of the dorsal tegmental nucleus. Significant expression is also detected in the spleen, thymus, lung, testis and ovary. Belongs to the insulin family. G-protein coupled receptor binding hormone activity extracellular region signal transduction uc009mls.1 uc009mls.2 uc009mls.3 
ENSMUST00000061925.5 Plcxd3 ENSMUST00000061925.5 phosphatidylinositol-specific phospholipase C, X domain containing 3 (from RefSeq NM_177355.3) ENSMUST00000061925.1 ENSMUST00000061925.2 ENSMUST00000061925.3 ENSMUST00000061925.4 G3X9A7 G3X9A7_MOUSE NM_177355 Plcxd3 uc007vcn.1 uc007vcn.2 uc007vcn.3 uc007vcn.4 uc007vcn.5 lipid metabolic process phosphoric diester hydrolase activity uc007vcn.1 uc007vcn.2 uc007vcn.3 uc007vcn.4 uc007vcn.5 
ENSMUST00000061936.8 Rnase2a ENSMUST00000061936.8 ribonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin) (from RefSeq NM_053113.2) ENSMUST00000061936.1 ENSMUST00000061936.2 ENSMUST00000061936.3 ENSMUST00000061936.4 ENSMUST00000061936.5 ENSMUST00000061936.6 ENSMUST00000061936.7 Ear11 NM_053113 Q8K196 Q8K196_MOUSE Rnase2a uc007tmw.1 uc007tmw.2 uc007tmw.3 uc007tmw.4 Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity ribonuclease activity hydrolase activity nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis uc007tmw.1 uc007tmw.2 uc007tmw.3 uc007tmw.4 
ENSMUST00000061937.13 Ctbs ENSMUST00000061937.13 chitobiase, transcript variant 1 (from RefSeq NM_001293672.1) DIAC_MOUSE ENSMUST00000061937.1 ENSMUST00000061937.10 ENSMUST00000061937.11 ENSMUST00000061937.12 ENSMUST00000061937.2 ENSMUST00000061937.3 ENSMUST00000061937.4 ENSMUST00000061937.5 ENSMUST00000061937.6 ENSMUST00000061937.7 ENSMUST00000061937.8 ENSMUST00000061937.9 NM_001293672 Q8R242 Q9D7V4 uc008rrh.1 uc008rrh.2 uc008rrh.3 uc008rrh.4 uc008rrh.5 Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase (By similarity). Lysosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R242-1; Sequence=Displayed; Name=2; IsoId=Q8R242-2; Sequence=VSP_013909; Belongs to the glycosyl hydrolase 18 family. hydrolase activity, hydrolyzing O-glycosyl compounds chitinase activity lysosome carbohydrate metabolic process chitin catabolic process chitin binding metabolic process oligosaccharide catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds uc008rrh.1 uc008rrh.2 uc008rrh.3 uc008rrh.4 uc008rrh.5 
ENSMUST00000061973.5 Trex1 ENSMUST00000061973.5 three prime repair exonuclease 1, transcript variant 1 (from RefSeq NM_011637.6) ENSMUST00000061973.1 ENSMUST00000061973.2 ENSMUST00000061973.3 ENSMUST00000061973.4 NM_011637 Q3TAD7 Q91XB0 Q9D6W2 Q9R1B0 TREX1_MOUSE Trex1 uc009rrr.1 uc009rrr.2 uc009rrr.3 Major cellular 3'-to-5' DNA exonuclease which digests single- stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini (PubMed:10391904, PubMed:11279105, PubMed:15254239, PubMed:17293595, PubMed:17355961, PubMed:18780819). Prevents cell- intrinsic initiation of autoimmunity (PubMed:18724932, PubMed:24218451). Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements (PubMed:18724932). Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation (By similarity). Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation (By similarity). Unless degraded, these DNA fragments accumulate in the cytosol and activate the cGAS-STING innate immune signaling, leading to the production of type I interferon (PubMed:18724932). Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates (PubMed:18045533). Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light (PubMed:23993650). During GZMA-mediated cell death, contributes to DNA damage in concert with NME1 (By similarity). NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity). Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.2; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Note=Binds 2 Mg(2+) per subunit. The second magnesium ion interacts with only one residue. Substitution with Mn(2+) results in partial activity. Calcium, lithium and sodium inhibit the exonuclease activity but not the DNA binding. pH dependence: Optimum pH is 7.5-8.0. ; Homodimer (PubMed:17293595, PubMed:17355961, PubMed:22071149). Interacts (via proline-rich region) with TCERG1/CA150 (via the second WW domain) (PubMed:17355961). Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1 (By similarity). Within this complex, directly interacts with SET; this interaction does not result in TREX1 inhibition (By similarity). Also interacts with NME1, but only following translocation to the nucleus (By similarity). Directly interacts with UBQLN1 (via ubiquitin-like domain); the interaction may control TREX1 subcellular location (By similarity). Nucleus toplasm, cytosol Endoplasmic reticulum membrane ; Peripheral membrane protein Note=Retained in the cytoplasm through the C-terminal region (PubMed:18045533). Localization to the endoplasmic reticulum membrane is required to direct TREX1 to ruptured micronuclei (By similarity). In response to DNA damage, translocates to the nucleus where it is specifically recruited to replication foci (PubMed:18045533). Translocation to the nucleus also occurs during GZMA-mediated cell death (PubMed:18045533). Widely expressed with high expression levels detected in spleen, thymus and uterus. Induced by cytosolic DNA. Induced by inflammatory stimuli in a cell-specific fashion. Up-regulated by IFN-alpha and IFN-gamma in B- cells and by LPS and viral and bacterial DNA (via Toll-like receptor signaling) in dendritic cells and macrophages. Ubiquitinated, but not targeted to proteasomal degradation. Ubiquitination may be important for interaction with UBQLN1 (By similarity). Mutant animals exhibit a dramatically reduced survival after weaning, with 50% of survival at 9 weeks (PubMed:18724932) or 17 weeks (PubMed:15254239). In 6-8 week old animals, multiple organs show extensive inflammation. The most severe diffuse lymphocytic infiltration occurs in the heart, followed by the lung, the liver, the smooth muscle of the uterus and the salivary gland with periductal infiltration. Other tissues exhibit only minimal to mild lymphocytic infiltration (PubMed:24218451). The heart phenotype includes inflammatory myocarditis leading to progressive, often dilated, cardiomyopathy and circulatory failure. Enlargement of the spleen and lymph nodes is observed in less than 10% of old mice (over 1 year of age) (PubMed:15254239). Mutant animals have a reduced 3'- exonuclease activity. They accumulate ssDNA from endogenous retroelements and produce high levels of autoantibodies. Do not show an increase in spontaneous mutation frequency or cancer incidence. Double knockout of TREX1 and either IRF3, IFNAR1 or RAG2 fully rescues the TREX1 single knockout phenotype (PubMed:18724932). Belongs to the exonuclease superfamily. TREX family. magnesium ion binding blood vessel development kidney development adaptive immune response organ or tissue specific immune response activation of immune response macrophage activation involved in immune response lymphoid progenitor cell differentiation immunoglobulin biosynthetic process involved in immune response immune response in brain or nervous system inflammatory response to antigenic stimulus T cell antigen processing and presentation regulation of immunoglobulin production heart morphogenesis heart process atrial cardiac muscle tissue development nucleic acid binding DNA binding double-stranded DNA binding single-stranded DNA binding nuclease activity exonuclease activity protein binding nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol generation of precursor metabolites and energy regulation of glycolytic process DNA metabolic process DNA replication DNA modification DNA catabolic process inflammatory response immune response cellular response to DNA damage stimulus oligosaccharyltransferase complex 3'-5'-exodeoxyribonuclease activity DNA binding, bending determination of adult lifespan 3'-5' exonuclease activity exodeoxyribonuclease III activity response to UV regulation of gene expression membrane hydrolase activity regulation of fatty acid metabolic process regulation of cellular metabolic process transposition, RNA-mediated MutLalpha complex binding MutSalpha complex binding regulation of type I interferon production DNA duplex unwinding adenyl deoxyribonucleotide binding interferon-alpha production regulation of tumor necrosis factor production protein-DNA complex cellular response to oxidative stress cellular response to reactive oxygen species cellular response to UV cellular response to interferon-beta CD86 biosynthetic process protein homodimerization activity apoptotic cell clearance regulation of cellular respiration nuclear replication fork innate immune response regulation of innate immune response establishment of protein localization metal ion binding regulation of lipid biosynthetic process WW domain binding regulation of inflammatory response regulation of catalytic activity protein stabilization regulation of T cell activation defense response to virus type I interferon signaling pathway negative regulation of type I interferon-mediated signaling pathway regulation of protein complex stability cellular response to organic substance cellular response to type I interferon cellular response to gamma radiation detection of stimulus involved in cell cycle checkpoint detection of DNA damage stimulus involved in DNA damage checkpoint signal transduction involved in DNA damage checkpoint cellular response to hydroxyurea nucleic acid phosphodiester bond hydrolysis immune complex formation DNA synthesis involved in UV-damage excision repair regulation of lysosome organization uc009rrr.1 uc009rrr.2 uc009rrr.3 
ENSMUST00000061986.12 Shb ENSMUST00000061986.12 src homology 2 domain-containing transforming protein B (from RefSeq NM_001033306.2) A2AKW3 ENSMUST00000061986.1 ENSMUST00000061986.10 ENSMUST00000061986.11 ENSMUST00000061986.2 ENSMUST00000061986.3 ENSMUST00000061986.4 ENSMUST00000061986.5 ENSMUST00000061986.6 ENSMUST00000061986.7 ENSMUST00000061986.8 ENSMUST00000061986.9 NM_001033306 Q3ULM3 Q6PD21 SHB_MOUSE uc008sst.1 uc008sst.2 uc008sst.3 uc008sst.4 Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin- producing cells (By similarity). Interacts with phosphorylated 'Tyr-720' of the ligand- activated receptor PDGFRA via its SH2 domain. Interacts with the ligand-activated receptors PDGFRB, FGFR1, KDR/VEGFR2, IL2RB and IL2RG. Interacts with EPS8 and V-SRC. Interacts with GRB2 and GRAP. Interacts with CD3Z. Interacts with tyrosine-phosphorylated LAT upon T-cell antigen receptor activation. Interacts with PLCG1. Interacts with ZAP70, LCP2/SLP-76, VAV1 and GRAP2. Interacts with JAK1 and JAK3. Interacts with PTK2/FAK1. Interacts with CRK/CrKII. Interacts with IRS2 (By similarity). Interacts with PTPN11. Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Associates with membrane lipid rafts upon TCR stimulation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PD21-1; Sequence=Displayed; Name=2; IsoId=Q6PD21-2; Sequence=VSP_019848, VSP_019849, VSP_019850; Expressed in heart, liver, brain and kidney (at protein level). Up-regulated by okadaic acid and genistein. The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII. Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation. Sequence=AAH58986.1; Type=Erroneous initiation; Evidence=; angiogenesis blood vessel development phosphotyrosine binding SH3/SH2 adaptor activity protein binding nucleoplasm cytoplasm cytosol plasma membrane negative regulation of protein kinase activity apoptotic process signal transduction multicellular organism development positive regulation of signal transduction membrane hemopoiesis cell differentiation cytoplasmic ribonucleoprotein granule B cell proliferation positive regulation of T-helper cell differentiation positive regulation of mitotic cell cycle blood vessel morphogenesis T cell receptor signaling pathway hematopoietic stem cell proliferation negative regulation of oocyte maturation uc008sst.1 uc008sst.2 uc008sst.3 uc008sst.4 
ENSMUST00000061995.10 Spryd4 ENSMUST00000061995.10 SPRY domain containing 4 (from RefSeq NM_025716.2) ENSMUST00000061995.1 ENSMUST00000061995.2 ENSMUST00000061995.3 ENSMUST00000061995.4 ENSMUST00000061995.5 ENSMUST00000061995.6 ENSMUST00000061995.7 ENSMUST00000061995.8 ENSMUST00000061995.9 NM_025716 Q8BUS6 Q91WK1 Q9D651 SPRY4_MOUSE uc007hlq.1 uc007hlq.2 uc007hlq.3 uc007hlq.4 Sequence=BAB29469.1; Type=Frameshift; Evidence=; molecular_function nucleus mitochondrion biological_process uc007hlq.1 uc007hlq.2 uc007hlq.3 uc007hlq.4 
ENSMUST00000062000.6 Foxo4 ENSMUST00000062000.6 forkhead box O4 (from RefSeq NM_018789.2) Afx Afx1 ENSMUST00000062000.1 ENSMUST00000062000.2 ENSMUST00000062000.3 ENSMUST00000062000.4 ENSMUST00000062000.5 FOXO4_MOUSE Fkhr3 Mllt7 NM_018789 Q9WVH3 uc009twz.1 uc009twz.2 uc009twz.3 Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity (By similarity). Represses smooth muscle cell differentiation by inhibiting the transcriptional coactivator activity of myocardin. Interacts with CREBBP/CBP, MYOCD, SIRT1, SRF and YWHAZ. Acetylated by CREBBP/CBP and deacetylated by SIRT1. Binding of YWHAZ inhibits DNA-binding. Interacts with USP7; the interaction is enhanced in presence of hydrogen peroxide and occurs independently of TP53. Interacts with NLK, and this inhibits monoubiquitination and transcriptional activity (By similarity). Interacts with FOXK1; the interaction inhibits MEF2C transactivation activity (PubMed:22956541). Q9WVH3; P56558: Ogt; Xeno; NbExp=2; IntAct=EBI-4567305, EBI-7614183; Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm (By similarity). Strongly expressed in brown adipose tissue and weakly in white adipose tissue (at protein level). Expressed in skeletal muscle. By artery ligation in proliferating neointimal smooth muscle cells. Acetylation by CREBBP/CBP is induced by oxidative stress and inhibits transcriptional activity. Deacetylation by SIRT1 is NAD- dependent and stimulates transcriptional activity (By similarity). Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization. May be phosphorylated at multiple sites by NLK (By similarity). Monoubiquitinated; monoubiquitination is induced by oxidative stress and reduced by deacetylase inhibitors; results in its relocalization to the nucleus and its increased transcriptional activity. Deubiquitinated by USP7; deubiquitination is induced by oxidative stress; enhances its interaction with USP7 and consequently, deubiquitination; increases its translocation to the cytoplasm and inhibits its transcriptional activity. Hydrogene-peroxide-induced ubiquitination and USP7-mediated deubiquitination have no major effect on its protein stability (By similarity). negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated cell cycle cell cycle arrest mitotic G2 DNA damage checkpoint multicellular organism development muscle organ development aging beta-catenin binding transcription factor binding negative regulation of cell proliferation insulin receptor signaling pathway positive regulation of smooth muscle cell migration negative regulation of angiogenesis nuclear speck enzyme binding cell differentiation response to nutrient levels glucose homeostasis identical protein binding sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter stem cell differentiation negative regulation of smooth muscle cell differentiation negative regulation of G0 to G1 transition positive regulation of cell cycle arrest response to water-immersion restraint stress promoter-specific chromatin binding uc009twz.1 uc009twz.2 uc009twz.3 
ENSMUST00000062002.6 Mafa ENSMUST00000062002.6 MAF bZIP transcription factor A (from RefSeq NM_194350.2) ENSMUST00000062002.1 ENSMUST00000062002.2 ENSMUST00000062002.3 ENSMUST00000062002.4 ENSMUST00000062002.5 MAFA_MOUSE NM_194350 Q8CF90 uc007whe.1 uc007whe.2 uc007whe.3 Transcriptional factor that activates insulin gene expression (PubMed:12368292, PubMed:15665000). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15665000). Binds the insulin enhancer C1/RIPE3b element (PubMed:12917329, PubMed:14680841, PubMed:14973194, PubMed:15665000). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (By similarity). Forms homodimers (By similarity). Interacts with NEUROD1 and PDX1 (PubMed:15665000). May interact with MAFB, FOS, JUN and PCAF (By similarity). Nucleus Expressed in brain, lung, spleen, pancreas and kidney (PubMed:12368292, PubMed:14680841). In the pancreas, expressed in the insulin-producing beta-cells of the islets of Langerhans (at protein level) (PubMed:12917329, PubMed:15923615). Also expressed in the eye (PubMed:12368292, PubMed:15923615). In the developing pancreas, expressed exclusively in the insulin-positive cells from 13.5 dpc onward and never in the glucagon-expressing cells (at protein level) (PubMed:14973194). At 12.5dpc, at the mRNA level, detected in each formed somite, in myotomal cells. Also detected in the head neural tube, liver cells and, at low levels, in some mesenchyme-like cells (PubMed:14680841). Up-regulated by glucose in pancreatic beta-cell lines. Ubiquitinated, leading to its degradation by the proteasome. Phosphorylated at tyrosines. Mice are born at the expected Mendelian rate and survive until adulthood. They show a normal pancreatic morphology at birth. A 12 weeks, they exhibit a reduction in the proportion of Langerhans islet beta-cells and impaired glucose-stimulated insulin secretion and eventually they develop diabetes mellitus. Belongs to the bZIP family. Maf subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated nitric oxide mediated signal transduction response to glucose insulin secretion sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc007whe.1 uc007whe.2 uc007whe.3 
ENSMUST00000062010.10 Rtl3 ENSMUST00000062010.10 retrotransposon Gag like 3 (from RefSeq NM_199468.2) ENSMUST00000062010.1 ENSMUST00000062010.2 ENSMUST00000062010.3 ENSMUST00000062010.4 ENSMUST00000062010.5 ENSMUST00000062010.6 ENSMUST00000062010.7 ENSMUST00000062010.8 ENSMUST00000062010.9 MArt3 Mar3 NM_199468 Q6P1Y1 RTL3_MOUSE Rtl3 Zcchc5 uc009ubw.1 uc009ubw.2 uc009ubw.3 May function as a transcriptional regulator (Probable). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912). Nucleus Expressed in embryonic myogenic progenitor cells, not expressed in adult and aged satellite cells. In myogenic progenitor cells, not expressed during early myogenic development, appears during early formation of the satellite cell pool (from 12.5 dpc to 17.5 dpc), before being completely down-regulated during adquisition of satellite cell quiescence. RTL3 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. molecular_function nucleic acid binding cellular_component nucleus biological_process zinc ion binding metal ion binding uc009ubw.1 uc009ubw.2 uc009ubw.3 
ENSMUST00000062024.3 Trarg1 ENSMUST00000062024.3 trafficking regulator of GLUT4 (SLC2A4) 1 (from RefSeq NM_177709.3) ENSMUST00000062024.1 ENSMUST00000062024.2 NM_177709 Q8C838 TARG1_MOUSE Tusc5 uc007kfy.1 uc007kfy.2 uc007kfy.3 uc007kfy.4 Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. Interacts with SLC2A4; the interaction is required for proper SLC2A4 reacycling after insulin stimulation. Cell membrane ingle-pass membrane protein Endomembrane system ; Single-pass membrane protein Cytoplasm, perinuclear region Note=Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation. Expressed specifically in white and brown adipose tissues. Target gene of PPARG, expression is induced upon PPARG activation (PubMed:26629404, PubMed:26240143). Expression is inhibited by TNF (PubMed:26240143). Mutant adipocytes show reduced glucose uptake in response to an insulin stimulus (PubMed:26629404). Knockout animals placed on high-fat diet along with wild-type littermates exhibit an increased weight gain, significant elevated blood insulin and glucose levelswith insulin resistance (PubMed:26629404). Belongs to the CD225/Dispanin family. protein binding cytoplasm plasma membrane endomembrane system membrane integral component of membrane cytoplasmic vesicle membrane cellular response to insulin stimulus glucose import in response to insulin stimulus perinuclear region of cytoplasm protein localization to plasma membrane vesicle fusion to plasma membrane endosome to plasma membrane protein transport uc007kfy.1 uc007kfy.2 uc007kfy.3 uc007kfy.4 
ENSMUST00000062028.8 Gpr61 ENSMUST00000062028.8 G protein-coupled receptor 61, transcript variant 2 (from RefSeq NM_001411298.1) ENSMUST00000062028.1 ENSMUST00000062028.2 ENSMUST00000062028.3 ENSMUST00000062028.4 ENSMUST00000062028.5 ENSMUST00000062028.6 ENSMUST00000062028.7 GPR61_MOUSE NM_001411298 Q3UZR6 Q8C010 uc008qye.1 uc008qye.2 uc008qye.3 uc008qye.4 Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). May be involved in the regulation of food intake and body weight (PubMed:21971119). Forms heterodimer with MTNR1B. Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR61 in the endosomal compartment (By similarity). Cell membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Note=Colocalizes with ARRB2/beta-arrestin-2 in the endosome (By similarity). Predominantly expressed in the brain and testes, with relatively lower expression observed in the eye, adrenal gland and pituitary gland. Deficient mice exhibit obesity associated with hyperphagia. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity endosome plasma membrane signal transduction G-protein coupled receptor signaling pathway endosome membrane membrane integral component of membrane receptor complex positive regulation of cAMP-mediated signaling arrestin family protein binding uc008qye.1 uc008qye.2 uc008qye.3 uc008qye.4 
ENSMUST00000062037.7 Clec4g ENSMUST00000062037.7 C-type lectin domain family 4, member g (from RefSeq NM_029465.3) CLC4G_MOUSE ENSMUST00000062037.1 ENSMUST00000062037.2 ENSMUST00000062037.3 ENSMUST00000062037.4 ENSMUST00000062037.5 ENSMUST00000062037.6 NM_029465 Q5I0T7 Q8BNX1 Q8R188 uc009ksp.1 uc009ksp.2 uc009ksp.3 uc009ksp.4 Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner. Q8BNX1; P56817: BACE1; Xeno; NbExp=2; IntAct=EBI-11176364, EBI-2433139; Cell membrane ; Single-pass type II membrane protein negative regulation of T cell mediated immunity protein binding plasma membrane membrane integral component of membrane carbohydrate binding polysaccharide binding negative regulation of T cell proliferation uc009ksp.1 uc009ksp.2 uc009ksp.3 uc009ksp.4 
ENSMUST00000062041.6 Crppa ENSMUST00000062041.6 CDP-L-ribitol pyrophosphorylase A, transcript variant 1 (from RefSeq NM_178629.6) ENSMUST00000062041.1 ENSMUST00000062041.2 ENSMUST00000062041.3 ENSMUST00000062041.4 ENSMUST00000062041.5 ISPD_MOUSE Ispd NM_178629 Q148Q0 Q501J8 Q5RJG7 Q8BR14 Q8C934 Q8CAE0 Q8CIF0 uc007nkb.1 uc007nkb.2 uc007nkb.3 uc007nkb.4 uc007nkb.5 Cytidylyltransferase required for protein O-linked mannosylation (By similarity). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (By similarity). CDP- ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3- N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (By similarity). Not involved in dolichol production (By similarity). Reaction=CTP + D-ribitol 5-phosphate + H(+) = CDP-L-ribitol + diphosphate; Xref=Rhea:RHEA:12456, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:57608, ChEBI:CHEBI:57695; EC=2.7.7.40; Evidence=; Reaction=CTP + D-ribose 5-phosphate + H(+) = CDP-D-ribose + diphosphate; Xref=Rhea:RHEA:53872, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:78346, ChEBI:CHEBI:137525; Evidence=; Reaction=CTP + D-ribulose 5-phosphate + H(+) = CDP-D-ribulose + diphosphate; Xref=Rhea:RHEA:53612, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:58121, ChEBI:CHEBI:137524; Evidence=; Protein modification; protein glycosylation. Homodimer. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q5RJG7-1; Sequence=Displayed; Name=2; IsoId=Q5RJG7-2; Sequence=VSP_034670, VSP_034671; Name=3; IsoId=Q5RJG7-3; Sequence=VSP_034668, VSP_034669; Name=4; IsoId=Q5RJG7-4; Sequence=VSP_034667, VSP_034668, VSP_034669; Name=5; IsoId=Q5RJG7-5; Sequence=VSP_034672, VSP_034673; Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. Sequence=BAC32538.1; Type=Frameshift; Evidence=; catalytic activity cytoplasm cytosol protein glycosylation axon guidance isoprenoid biosynthetic process transferase activity nucleotidyltransferase activity protein O-linked mannosylation protein homodimerization activity D-ribitol-5-phosphate cytidylyltransferase activity cytidylyltransferase activity uc007nkb.1 uc007nkb.2 uc007nkb.3 uc007nkb.4 uc007nkb.5 
ENSMUST00000062045.4 H1f4 ENSMUST00000062045.4 H1.4 linker histone, cluster member (from RefSeq NM_015787.4) ENSMUST00000062045.1 ENSMUST00000062045.2 ENSMUST00000062045.3 H1-4 H14_MOUSE H1f4 Hist1h1e NM_015787 P43274 Q5EBH3 uc007puj.1 uc007puj.2 uc007puj.3 uc007puj.4 uc007puj.5 Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Nucleus. Chromosome. Note=Mainly localizes in heterochromatin. Dysplays a punctuate staining pattern in the nucleus. The C-terminal domain is required for high-affinity binding to chromatin. Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. ADP-ribosylated on Ser-55, Ser-113 and Ser-150 in response to DNA damage. H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT1. Hydroxybutyrylation of histones is induced by starvation. Triple-deficient mice (H1-2, H1-3 and H1-4) die by midgestation with a broad range of defects. These embryos have about 50% of the normal ratio of H1 to nucleosomes. This proves at least that a correct stoichiometry of linker histone deposition on chromatin is essential. Belongs to the histone H1/H5 family. negative regulation of transcription from RNA polymerase II promoter nucleotide binding nucleosome nuclear nucleosome nuclear chromatin DNA binding double-stranded DNA binding calcium ion binding protein binding ATP binding GTP binding nucleus chromosome nuclear euchromatin nuclear heterochromatin nucleosome assembly regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter AMP binding nucleosome positioning chromosome condensation chromatin DNA binding nucleosomal DNA binding negative regulation of chromatin silencing dATP binding ADP binding negative regulation of DNA recombination histone H3-K4 trimethylation histone H3-K27 trimethylation nucleolus uc007puj.1 uc007puj.2 uc007puj.3 uc007puj.4 uc007puj.5 
ENSMUST00000062047.6 Fam110a ENSMUST00000062047.6 family with sequence similarity 110, member A, transcript variant 2 (from RefSeq NM_146127.4) ENSMUST00000062047.1 ENSMUST00000062047.2 ENSMUST00000062047.3 ENSMUST00000062047.4 ENSMUST00000062047.5 F110A_MOUSE NM_146127 Q505P3 Q8BQE5 Q8K024 Q8R184 Q8VEM7 Q9CU80 uc008net.1 uc008net.2 uc008net.3 uc008net.4 May interact with CSPP1. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cytoplasm during mitosis, accumulating at spindle poles. Belongs to the FAM110 family. Sequence=BC018162; Type=Frameshift; Evidence=; spindle pole molecular_function cellular_component cytoplasm microtubule organizing center cytoskeleton biological_process uc008net.1 uc008net.2 uc008net.3 uc008net.4 
ENSMUST00000062058.5 Lix1l ENSMUST00000062058.5 Lix1-like (from RefSeq NM_001163170.1) ENSMUST00000062058.1 ENSMUST00000062058.2 ENSMUST00000062058.3 ENSMUST00000062058.4 G3X9C8 G3X9C8_MOUSE Lix1l NM_001163170 uc008qnh.1 uc008qnh.2 uc008qnh.3 Belongs to the LIX1 family. uc008qnh.1 uc008qnh.2 uc008qnh.3 
ENSMUST00000062060.5 4921504E06Rik ENSMUST00000062060.5 RIKEN cDNA 4921504E06 gene (from RefSeq NM_027600.4) 4921504E06Rik ENSMUST00000062060.1 ENSMUST00000062060.2 ENSMUST00000062060.3 ENSMUST00000062060.4 NM_027600 Q8CET2 Q8CET2_MOUSE uc008imi.1 uc008imi.2 uc008imi.3 molecular_function cellular_component biological_process uc008imi.1 uc008imi.2 uc008imi.3 
ENSMUST00000062067.8 Lamtor4 ENSMUST00000062067.8 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (from RefSeq NM_001081108.2) B7ZN18 ENSMUST00000062067.1 ENSMUST00000062067.2 ENSMUST00000062067.3 ENSMUST00000062067.4 ENSMUST00000062067.5 ENSMUST00000062067.6 ENSMUST00000062067.7 LTOR4_MOUSE NM_001081108 Q8CEW4 Q8CF66 Q8CF77 uc009afd.1 uc009afd.2 uc009afd.3 As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and RagD/RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator. Lysosome Phosphorylation at Ser-67 by PKA inhibits Ragulator complex assembly. Belongs to the LAMTOR4 family. Sequence=BAC24993.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC25020.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC25306.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; guanyl-nucleotide exchange factor activity lysosome regulation of cell size positive regulation of TOR signaling intracellular membrane-bounded organelle binding, bridging protein localization to lysosome cellular response to amino acid stimulus Ragulator complex uc009afd.1 uc009afd.2 uc009afd.3 
ENSMUST00000062069.6 Ptgs1 ENSMUST00000062069.6 prostaglandin-endoperoxide synthase 1 (from RefSeq NM_008969.4) ENSMUST00000062069.1 ENSMUST00000062069.2 ENSMUST00000062069.3 ENSMUST00000062069.4 ENSMUST00000062069.5 NM_008969 Ptgs1 Q543T1 Q543T1_MOUSE Q8CIL6 uc008jll.1 uc008jll.2 uc008jll.3 uc008jll.4 This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005573.1, AK159907.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## multifunctional gene product(s) :: PMID: 8121489 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2; Xref=Rhea:RHEA:42596, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:82629; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42597; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2; Xref=Rhea:RHEA:23728, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:32395, ChEBI:CHEBI:57405; EC=1.14.99.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23729; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)- octadecadienoate + A + H2O; Xref=Rhea:RHEA:75455, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:136655; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75456; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)- octadecadienoate + A + H2O; Xref=Rhea:RHEA:75451, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:90850; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75452; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)- octadecadienoate + A + H2O; Xref=Rhea:RHEA:75447, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:77895; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75448; Evidence=; Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)- octadecadienoate + A + H2O; Xref=Rhea:RHEA:75459, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:77852; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75460; Evidence=; Reaction=AH2 + prostaglandin G2 = A + H2O + prostaglandin H2; Xref=Rhea:RHEA:42600, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:57405, ChEBI:CHEBI:82629; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42601; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Lipid metabolism; prostaglandin biosynthesis. Homodimer. Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Belongs to the prostaglandin G/H synthase family. Lacks conserved residue(s) required for the propagation of feature annotation. prostaglandin biosynthetic process peroxidase activity prostaglandin-endoperoxide synthase activity cytoplasm Golgi apparatus inflammatory response response to oxidative stress regulation of blood pressure cyclooxygenase pathway heme binding intracellular membrane-bounded organelle oxidation-reduction process cellular oxidant detoxification uc008jll.1 uc008jll.2 uc008jll.3 uc008jll.4 
ENSMUST00000062085.6 Hsfy2 ENSMUST00000062085.6 heat shock transcription factor, Y-linked 2 (from RefSeq NM_027661.2) ENSMUST00000062085.1 ENSMUST00000062085.2 ENSMUST00000062085.3 ENSMUST00000062085.4 ENSMUST00000062085.5 Hsfy2 Hspy2l NM_027661 Q80Y37 Q80Y37_MOUSE uc007bar.1 uc007bar.2 uc007bar.3 uc007bar.4 uc007bar.5 Nucleus Belongs to the HSF family. RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated cellular response to heat sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter in response to heat stress uc007bar.1 uc007bar.2 uc007bar.3 uc007bar.4 uc007bar.5 
ENSMUST00000062108.10 Ikbke ENSMUST00000062108.10 inhibitor of kappaB kinase epsilon (from RefSeq NM_019777.3) ENSMUST00000062108.1 ENSMUST00000062108.2 ENSMUST00000062108.3 ENSMUST00000062108.4 ENSMUST00000062108.5 ENSMUST00000062108.6 ENSMUST00000062108.7 ENSMUST00000062108.8 ENSMUST00000062108.9 IKKE_MOUSE Ikke Ikki NM_019777 Q8C2I3 Q9R0T8 uc007cnf.1 uc007cnf.2 uc007cnf.3 Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I- like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. Reaction=ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L- seryl-[I-kappa-B protein]; Xref=Rhea:RHEA:19073, Rhea:RHEA- COMP:13698, Rhea:RHEA-COMP:13699, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.10; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19074; Evidence=; Kinase activity is inhibited competitively by amlexanox. Homodimer (By similarity). Interacts with MAVS/IPS1 (By similarity). Interacts (via protein kinase domain) with TTLL12 (via N- terminus); the interaction prevents MAVS binding to IKBKE (By similarity). Interacts with the adapter proteins AZI2/NAP1, TANK and TBKBP1/SINTBAD (PubMed:17568778). Interacts with SIKE1 (By similarity). Interacts with TICAM1/TRIF, IRF3 and RIGI; interactions are disrupted by the interaction between IKBKE and SIKE1 (By similarity). Interacts with TOPORS; induced by DNA damage (By similarity). Interacts with CYLD, IKBKB, IKBKG and MYD88 (By similarity). Interacts with IFIH1 (By similarity). Interacts with DDX3X; the interaction may be induced upon virus infection (By similarity). Interacts with TRIM6 (via SPRY box) (By similarity). Interacts with unanchored K48-linked polyubiquitin chains; this leads to IKBKE activation (By similarity). Interacts with TBK1 (By similarity). Interacts with FKBP5 (By similarity). Q9R0T8; Q8N7N6: Traf3ip2; NbExp=3; IntAct=EBI-6664658, EBI-646165; Cytoplasm Nucleus Nucleus, PML body Note=Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent. Located diffusely throughout the cytoplasm but locates to punctate cytoplasmic bodies when coexpressed with TRIM6. Expressed in bone marrow-derived macrophages and at low levels in liver and white adipose tissue (at protein level). Detected in muscle and lung. Induced by lipopolysaccharide (LPS) and TNFA. Under high-fat diet, highly induced (via NF-kappa-B) in adipocytes and M1-polarized adipose tissue macrophages. Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death. Desumoylated by SENP1 (By similarity). Autophosphorylated and phosphorylated by IKBKB/IKKB. Phosphorylation at Ser-172 is enhanced by the interaction with DDX3X. Phosphorylated at Thr-503 upon IFN activation. 'Lys-63'-linked polyubiquitinated at Lys-30 and Lys-403 by TRAF2:BIRC2 and TRAF2:BIRC3 complexes. Ubiquitination is induced by LPS, TNFA and interleukin-1 and required for full kinase activity and KF-kappa-B pathway activation (By similarity). Animals are hypersusceptible to influenza virus infection because of a defect in the activation of a subset of type 1 IFN-stimulated genes, however the amounts of IFNB produced are normals. Lungs of mice infected 7 days with influenza virus exhibit an inflammatory infiltrate consisting of lymphocytes, macrophages and neutrophils. After West Nile virus infection, animals display earlier neurological symptoms, a higher degree of neurovirulence and a failure to recover, compared to wild type. Animals are protected from high-fat diet-induced obesity, liver and adipose inflammation, hepatic steatosis and insulin resistance. They show an increased energy expenditure and thermogenesis and maintain insulin sensitivity in liver and adipose tissue. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity NF-kappaB-inducing kinase activity protein binding ATP binding nucleus cytoplasm protein phosphorylation cellular response to DNA damage stimulus I-kappaB phosphorylation IkappaB kinase activity intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of lipid storage kinase activity phosphorylation PML body transferase activity peptidyl-serine phosphorylation ubiquitin protein ligase binding mitochondrial membrane response to type I interferon response to interferon-beta K48-linked polyubiquitin binding NIK/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling protein homooligomerization positive regulation of type I interferon-mediated signaling pathway cellular response to virus uc007cnf.1 uc007cnf.2 uc007cnf.3 
ENSMUST00000062113.9 Defb12 ENSMUST00000062113.9 defensin beta 12 (from RefSeq NM_152802.4) DFB12_MOUSE ENSMUST00000062113.1 ENSMUST00000062113.2 ENSMUST00000062113.3 ENSMUST00000062113.4 ENSMUST00000062113.5 ENSMUST00000062113.6 ENSMUST00000062113.7 ENSMUST00000062113.8 NM_152802 Q8K4N3 uc009lac.1 uc009lac.2 uc009lac.3 uc009lac.4 Has antibacterial activity. Secreted Only expressed in epididymis (caput, corpus and cauda). Belongs to the beta-defensin family. Sequence=BAC10632.1; Type=Erroneous initiation; Evidence=; Sequence=BAC25621.1; Type=Erroneous initiation; Evidence=; molecular_function extracellular region defense response defense response to bacterium innate immune response defense response to Gram-negative bacterium uc009lac.1 uc009lac.2 uc009lac.3 uc009lac.4 
ENSMUST00000062117.14 Rap2a ENSMUST00000062117.14 RAS related protein 2a (from RefSeq NM_029519.3) ENSMUST00000062117.1 ENSMUST00000062117.10 ENSMUST00000062117.11 ENSMUST00000062117.12 ENSMUST00000062117.13 ENSMUST00000062117.2 ENSMUST00000062117.3 ENSMUST00000062117.4 ENSMUST00000062117.5 ENSMUST00000062117.6 ENSMUST00000062117.7 ENSMUST00000062117.8 ENSMUST00000062117.9 NM_029519 Q3USK1 Q7TSK4 Q80ZJ1 Q810A2 Q9D3D5 RAP2A_MOUSE uc007uzx.1 uc007uzx.2 uc007uzx.3 uc007uzx.4 Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Activated by the guanine nucleotide-exchange factors RAPGEF3 and RAPGEF4 in a cAMP-dependent manner. Nucleotide exchange is also specifically stimulated by RAPGEF5, RASGEF1A and RASGEF1B (By similarity). Interacts with PLCE1. Interacts with ARHGAP29, SGSM1, SGSM2 and SGSM3. Interacts (GTP-bound form preferentially) with MAP4K4. Interacts with MINK1. Interacts with cytoskeletal actin (By similarity). Interacts (GTP-bound form) with RUNDC3A. Interacts (GTP- bound form preferentially) with TNIK (via the CNH domain); the interaction is direct and recruits RAP2A to the E3 ubiquitin ligase NEDD4. Interacts with RGS14; the interaction is GTP-dependent. Midbody Recycling endosome membrane ; Lipid-anchor ; Cytoplasmic side Note=Localizes to midbody at telophase. May also localize to the Golgi and the gelatinase-containing granules of neutrophils. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80ZJ1-1; Sequence=Displayed; Name=2; IsoId=Q80ZJ1-2; Sequence=VSP_013381; Expressed in granular layer of the cerebellum, forebrain, striatum, layer V of the cortex, olfactory cortex, tubercules, subthalamic and hippocampus, particularly in the CA2 region, to a lesser extent in the CA1 region and the external layer of the dentate gyrus. Expressed in neurons. The effector domain mediates the interaction with RUNDC3A. Ubiquitinated; undergoes 'Lys-63' monoubiquitination and diubiquitination by NEDD4. Multiple lysine residues are probably modified. Ubiquitination requires TNIK, prevents interaction with effectors and inactivates RAP2A. Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK. Transgenic mice expressing a constitutively active form of Rap2a display impaired spatial learning and defective extinction of contextual fear. Belongs to the small GTPase superfamily. Ras family. nucleotide binding magnesium ion binding positive regulation of protein phosphorylation GTPase activity protein binding GTP binding endosome cytosol plasma membrane signal transduction membrane GDP binding microvillus assembly negative regulation of cell migration midbody actin cytoskeleton reorganization positive regulation of protein autophosphorylation Rap protein signal transduction cellular protein localization cellular response to drug establishment of protein localization regulation of JNK cascade regulation of dendrite morphogenesis recycling endosome recycling endosome membrane protein localization to plasma membrane uc007uzx.1 uc007uzx.2 uc007uzx.3 uc007uzx.4 
ENSMUST00000062118.11 Pigv ENSMUST00000062118.11 phosphatidylinositol glycan anchor biosynthesis, class V, transcript variant 1 (from RefSeq NM_178698.5) ENSMUST00000062118.1 ENSMUST00000062118.10 ENSMUST00000062118.2 ENSMUST00000062118.3 ENSMUST00000062118.4 ENSMUST00000062118.5 ENSMUST00000062118.6 ENSMUST00000062118.7 ENSMUST00000062118.8 ENSMUST00000062118.9 NM_178698 PIGV_MOUSE Q7TPN3 Q8BGL2 Q8BJR5 Q8BWH9 Q8BXF5 uc008vdf.1 uc008vdf.2 uc008vdf.3 uc008vdf.4 Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity). Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TPN3-1; Sequence=Displayed; Name=2; IsoId=Q7TPN3-2; Sequence=VSP_019840; Not N-glycosylated. Belongs to the PIGV family. Sequence=BAC33023.1; Type=Erroneous initiation; Evidence=; mannosyltransferase activity dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups mannosyltransferase complex mannosylation uc008vdf.1 uc008vdf.2 uc008vdf.3 uc008vdf.4 
ENSMUST00000062122.4 Cmya5 ENSMUST00000062122.4 cardiomyopathy associated 5 (from RefSeq NM_023821.3) Cmya5 E9QLJ0 E9QLJ0_MOUSE ENSMUST00000062122.1 ENSMUST00000062122.2 ENSMUST00000062122.3 NM_023821 uc007rky.1 uc007rky.2 uc007rky.3 uc007rky.4 uc007rky.1 uc007rky.2 uc007rky.3 uc007rky.4 
ENSMUST00000062125.11 Timm29 ENSMUST00000062125.11 translocase of inner mitochondrial membrane 29 (from RefSeq NM_178619.4) ENSMUST00000062125.1 ENSMUST00000062125.10 ENSMUST00000062125.2 ENSMUST00000062125.3 ENSMUST00000062125.4 ENSMUST00000062125.5 ENSMUST00000062125.6 ENSMUST00000062125.7 ENSMUST00000062125.8 ENSMUST00000062125.9 NM_178619 Q8BGX2 TIM29_MOUSE uc009omb.1 uc009omb.2 uc009omb.3 Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40. Component of the TIM22 complex, which core is composed of TIMM22, associated with TIMM10 (TIMM10A and/or TIMM10B), TIMM9, AGK and TIMM29. Interacts with TIMM10B; the interaction is direct. Interacts with TOMM40; linking the TIM22 complex to the TOM complex. Interacts with TIMM22 (when oxidized); the interaction is direct. Mitochondrion inner membrane ; Single-pass membrane protein ; Intermembrane side molecular_function mitochondrion mitochondrial inner membrane mitochondrial intermembrane space protein transport membrane integral component of membrane mitochondrial inner membrane protein insertion complex protein import into mitochondrial inner membrane uc009omb.1 uc009omb.2 uc009omb.3 
ENSMUST00000062129.2 Sprr4 ENSMUST00000062129.2 small proline-rich protein 4 (from RefSeq NM_173070.1) ENSMUST00000062129.1 NM_173070 Q3KNY6 Q8CGN8 SPRR4_MOUSE uc008qee.1 uc008qee.2 Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification (By similarity). Cytoplasm Cytoplasm, cell cortex Note=Translocates to the cell periphery of keratinocytes and is integrated into both rigid and fragile cornified envelopes. Cross-linked to membrane proteins by transglutaminase. Belongs to the cornifin (SPRR) family. cytoplasm cell cortex keratinization uc008qee.1 uc008qee.2 
ENSMUST00000062144.4 Or51v8 ENSMUST00000062144.4 olfactory receptor family 51 subfamily V member 8 (from RefSeq NM_001011865.2) ENSMUST00000062144.1 ENSMUST00000062144.2 ENSMUST00000062144.3 F8VQI7 F8VQI7_MOUSE NM_001011865 Olfr624 Or51v8 uc009iuh.1 uc009iuh.2 uc009iuh.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009iuh.1 uc009iuh.2 uc009iuh.3 
ENSMUST00000062145.2 4933430I17Rik ENSMUST00000062145.2 RIKEN cDNA 4933430I17 gene, transcript variant 1 (from RefSeq NM_177607.4) 4933430I17Rik ENSMUST00000062145.1 F6UZS4 F6UZS4_MOUSE NM_177607 uc008tfc.1 uc008tfc.2 uc008tfc.1 uc008tfc.2 
ENSMUST00000062148.9 Mcts2 ENSMUST00000062148.9 malignant T cell amplified sequence 2 (from RefSeq NM_025543.3) ENSMUST00000062148.1 ENSMUST00000062148.2 ENSMUST00000062148.3 ENSMUST00000062148.4 ENSMUST00000062148.5 ENSMUST00000062148.6 ENSMUST00000062148.7 ENSMUST00000062148.8 MCTS2_MOUSE Mcts2 NM_025543 Q9CQ21 uc008nge.1 uc008nge.2 uc008nge.3 uc008nge.4 Cytoplasm Imprinted gene expressed from the paternal allele in blastocysts. Belongs to the MCTS1 family. formation of translation preinitiation complex translation reinitiation RNA binding cytoplasm cytosolic small ribosomal subunit uc008nge.1 uc008nge.2 uc008nge.3 uc008nge.4 
ENSMUST00000062153.12 Rilpl1 ENSMUST00000062153.12 Rab interacting lysosomal protein-like 1, transcript variant 2 (from RefSeq NM_021430.3) ENSMUST00000062153.1 ENSMUST00000062153.10 ENSMUST00000062153.11 ENSMUST00000062153.2 ENSMUST00000062153.3 ENSMUST00000062153.4 ENSMUST00000062153.5 ENSMUST00000062153.6 ENSMUST00000062153.7 ENSMUST00000062153.8 ENSMUST00000062153.9 MNCb-2440 NM_021430 Q80WV8 Q9JJC6 RIPL1_MOUSE uc008zpz.1 uc008zpz.2 Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (By similarity). Plays a role in the regulation of cell shape and polarity (PubMed:23264467). Plays a role in cellular protein transport, including protein transport away from primary cilia (PubMed:23264467). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (By similarity). Interacts (when S-nitrosylated) with GAPDH (By similarity). Interacts with RAB8A; interaction is dependent on the phosphorylation of 'Thr-72' of RAB8A (PubMed:29125462). Interacts with RAB10 and RAB12; the interaction is dependent on the phosphorylation of 'Thr-73' of RAB10, and 'Ser-105' of RAB12 (By similarity). Cytoplasm, cytosol Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole S-nitrosylation is required for the interaction with GAPDH. Belongs to the RILPL family. epithelial cell morphogenesis nucleoplasm cytoplasm centrosome centriole cytosol cytoskeleton plasma membrane cilium protein transport small GTPase binding cell projection protein dimerization activity dynein light intermediate chain binding regulation of neuron death protein transport from ciliary membrane to plasma membrane uc008zpz.1 uc008zpz.2 
ENSMUST00000062159.9 1600012P17Rik ENSMUST00000062159.9 RIKEN cDNA 1600012P17 gene (from RefSeq NR_163823.1) ENSMUST00000062159.1 ENSMUST00000062159.2 ENSMUST00000062159.3 ENSMUST00000062159.4 ENSMUST00000062159.5 ENSMUST00000062159.6 ENSMUST00000062159.7 ENSMUST00000062159.8 NR_163823 uc007ddx.1 uc007ddx.2 uc007ddx.3 uc007ddx.1 uc007ddx.2 uc007ddx.3 
ENSMUST00000062160.4 Sprr1b ENSMUST00000062160.4 small proline-rich protein 1B (from RefSeq NM_009265.5) ENSMUST00000062160.1 ENSMUST00000062160.2 ENSMUST00000062160.3 NM_009265 Q0VEC0 Q62267 SPR1B_MOUSE uc008qeb.1 uc008qeb.2 uc008qeb.3 Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Cytoplasm. Expressed in fetal periderm, hair follicles and in the thickened epidermis of the lip and footpad. Also present in the epithelia of various tissues such as the penis, vagina, forestomach, tongue and esophagus. First detected in fetal skin around day 16 and expression continues throughout newborn and adult stages. Belongs to the cornifin (SPRR) family. cornified envelope structural constituent of cytoskeleton cytoplasm cytoskeleton organization regulation of cell shape keratinization uc008qeb.1 uc008qeb.2 uc008qeb.3 
ENSMUST00000062163.8 Mrgprd ENSMUST00000062163.8 MAS-related GPR, member D (from RefSeq NM_203490.4) ENSMUST00000062163.1 ENSMUST00000062163.2 ENSMUST00000062163.3 ENSMUST00000062163.4 ENSMUST00000062163.5 ENSMUST00000062163.6 ENSMUST00000062163.7 Gm499 MRGRD_MOUSE Mrgd NM_203490 Q91ZB8 uc009kra.1 uc009kra.2 uc009kra.3 May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i) (By similarity). Cell membrane; Multi-pass membrane protein. Expressed in a subset of sensory neurons that includes nociceptors. Expressed in the subclass of non-peptidergic sensory neurons that are IB4(+) and VR1(-). Belongs to the G-protein coupled receptor 1 family. Mas subfamily. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009kra.1 uc009kra.2 uc009kra.3 
ENSMUST00000062181.9 Zfp146 ENSMUST00000062181.9 zinc finger protein 146, transcript variant 1 (from RefSeq NM_011980.4) A0JNX3 ENSMUST00000062181.1 ENSMUST00000062181.2 ENSMUST00000062181.3 ENSMUST00000062181.4 ENSMUST00000062181.5 ENSMUST00000062181.6 ENSMUST00000062181.7 ENSMUST00000062181.8 NM_011980 OZF_MOUSE Ozf Q8BQN6 Q9Z0Q5 Znf146 uc009gdn.1 uc009gdn.2 uc009gdn.3 uc009gdn.4 Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP (By similarity). Nucleus Expressed in heart, brain, liver, lung, skeletal muscle and kidney, and at much lower level in spleen and testicle. Expressed in lactating mammary gland. Mice lacking Zfp146 in mammary gland display impaired mammary gland development. They cannot sustain full growth of their pups. This phenotype is associated with an impaired mammary gland development noticeable only after mid-gestation. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC33129.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleolus cytosol regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc009gdn.1 uc009gdn.2 uc009gdn.3 uc009gdn.4 
ENSMUST00000062182.8 Gm4787 ENSMUST00000062182.8 predicted gene 4787 (from RefSeq NM_001038995.2) B2RUD9 B2RUD9_MOUSE EG214321 ENSMUST00000062182.1 ENSMUST00000062182.2 ENSMUST00000062182.3 ENSMUST00000062182.4 ENSMUST00000062182.5 ENSMUST00000062182.6 ENSMUST00000062182.7 Gm4787 NM_001038995 uc007ocb.1 uc007ocb.2 uc007ocb.3 Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function metalloendopeptidase activity cellular_component proteolysis biological_process metallopeptidase activity membrane integral component of membrane uc007ocb.1 uc007ocb.2 uc007ocb.3 
ENSMUST00000062202.14 Sned1 ENSMUST00000062202.14 sushi, nidogen and EGF-like domains 1 (from RefSeq NM_172463.5) A0A0R4J0N0 A0A0R4J0N0_MOUSE ENSMUST00000062202.1 ENSMUST00000062202.10 ENSMUST00000062202.11 ENSMUST00000062202.12 ENSMUST00000062202.13 ENSMUST00000062202.2 ENSMUST00000062202.3 ENSMUST00000062202.4 ENSMUST00000062202.5 ENSMUST00000062202.6 ENSMUST00000062202.7 ENSMUST00000062202.8 ENSMUST00000062202.9 NM_172463 Sned1 uc007cdm.1 uc007cdm.2 uc007cdm.3 Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding cell-matrix adhesion uc007cdm.1 uc007cdm.2 uc007cdm.3 
ENSMUST00000062206.3 Dynlt4 ENSMUST00000062206.3 dynein light chain Tctex-type 4 (from RefSeq NM_175030.2) A2AE79 A2AE80 DYLT4_MOUSE ENSMUST00000062206.1 ENSMUST00000062206.2 NM_175030 Q14C28 Q8CDY7 Tctex1d4 uc008uia.1 uc008uia.2 uc008uia.3 Interacts with ENG/endoglin, TGFBR2 and TGFBR3. Interacts with PPP1CC. Cell projection, cilium, flagellum Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm Nucleus Cytoplasm, cytoskeleton, microtubule organizing center Note=Present along the entire length of the flagellum, including principal and endpiece, and more predominantly in the midpiece region. Expression is elevated in spermatocytes, this expression is maintained high in the round spermatids with a decreased in elongated spermatid. Belongs to the dynein light chain Tctex-type family. acrosomal vesicle nucleus cytoplasm microtubule organizing center axoneme biological_process protein phosphatase 1 binding sperm flagellum uc008uia.1 uc008uia.2 uc008uia.3 
ENSMUST00000062211.4 Gpat2 ENSMUST00000062211.4 glycerol-3-phosphate acyltransferase 2, mitochondrial (from RefSeq NM_001081089.2) B1AW16 ENSMUST00000062211.1 ENSMUST00000062211.2 ENSMUST00000062211.3 GPAT2_MOUSE Gpat2 NM_001081089 Q0KK60 Q14CH8 Q14DK4 Q6KAQ3 Q8BRZ9 uc008mfj.1 uc008mfj.2 uc008mfj.3 Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids (PubMed:17013544, PubMed:17689486, PubMed:22905194). In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA) (PubMed:22905194). Prefers arachidonoyl-CoA as the acyl donor (PubMed:22905194). Required for primary processing step during piRNA biosynthesis (PubMed:23611983). Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity (PubMed:23611983). Reaction=an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3- phosphate + CoA; Xref=Rhea:RHEA:15325, ChEBI:CHEBI:57287, ChEBI:CHEBI:57597, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342; EC=2.3.1.15; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15326; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19710; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74544, ChEBI:CHEBI:74546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37132; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn- glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37443, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74544, ChEBI:CHEBI:74928; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37444; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37463, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:57597, ChEBI:CHEBI:74938; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37464; Evidence=; Inhibited by N-ethylmaleimide (NEM). Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 1/3. Interacts with PIWIL2 (PubMed:23611983). Mitochondrion outer membrane ulti-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14DK4-1; Sequence=Displayed; Name=2; IsoId=Q14DK4-2; Sequence=VSP_032457, VSP_032458; Name=3; IsoId=Q14DK4-3; Sequence=VSP_032457; Highly expressed in the testis (PubMed:26268560). Expressed at lower levels in the heart, liver, kidney, spleen and adipose cells (PubMed:17013544, PubMed:17689486). Only detected in primary spermatocytes (PubMed:22905194). Highly expressed in pachytene spermatocytes (at protein level) (PubMed:26268560). Up-regulated by retinoic acid (PubMed:26268560). The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. Belongs to the GPAT/DAPAT family. Sequence=AAI13777.1; Type=Erroneous initiation; Evidence=; Sequence=BAD21404.1; Type=Erroneous initiation; Evidence=; glycerol-3-phosphate O-acyltransferase activity protein binding mitochondrion mitochondrial outer membrane glycerol-3-phosphate metabolic process lipid metabolic process fatty acid metabolic process O-acyltransferase activity phospholipid biosynthetic process membrane integral component of membrane CDP-diacylglycerol biosynthetic process transferase activity transferase activity, transferring acyl groups triglyceride biosynthetic process mitochondrial membrane cellular lipid metabolic process piRNA biosynthetic process uc008mfj.1 uc008mfj.2 uc008mfj.3 
ENSMUST00000062213.13 Sfxn3 ENSMUST00000062213.13 sideroflexin 3, transcript variant 7 (from RefSeq NR_155547.1) ENSMUST00000062213.1 ENSMUST00000062213.10 ENSMUST00000062213.11 ENSMUST00000062213.12 ENSMUST00000062213.2 ENSMUST00000062213.3 ENSMUST00000062213.4 ENSMUST00000062213.5 ENSMUST00000062213.6 ENSMUST00000062213.7 ENSMUST00000062213.8 ENSMUST00000062213.9 NR_155547 Q544M7 Q8C1Z2 Q91V61 SFXN3_MOUSE Sfxn3 uc012bml.1 uc012bml.2 uc012bml.3 Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Reaction=L-serine(in) = L-serine(out); Xref=Rhea:RHEA:35031, ChEBI:CHEBI:33384; Evidence=; Mitochondrion membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91V61-1; Sequence=Displayed; Name=2; IsoId=Q91V61-2; Sequence=VSP_007388; Widely expressed. Belongs to the sideroflexin family. mitochondrion one-carbon metabolic process ion transport amino acid transport ion transmembrane transporter activity membrane integral component of membrane serine transmembrane transporter activity mitochondrial membrane transmembrane transport mitochondrial transmembrane transport uc012bml.1 uc012bml.2 uc012bml.3 
ENSMUST00000062216.4 Emx2 ENSMUST00000062216.4 empty spiracles homeobox 2 (from RefSeq NM_010132.2) EMX2_MOUSE ENSMUST00000062216.1 ENSMUST00000062216.2 ENSMUST00000062216.3 Emx-2 G3X9A6 NM_010132 Q04744 Q80UE7 uc008ibl.1 uc008ibl.2 uc008ibl.3 Transcription factor, which in cooperation with EMX1, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combination with OTX1/2 to specify cell fates in the developing central nervous system. Interacts with translation initiation factor EIF4E. Nucleus Cell projection, axon Note=Detected in axons within the olfactory mucosa and glomeruli in the olfactory bulb. Expressed in immature and mature olfactory sensory neurons (at protein level) (PubMed:15247416). Cerebral cortex (PubMed:1352754). Belongs to the EMX homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development central nervous system development brain development anterior/posterior pattern specification regulation of gene expression dentate gyrus development cerebral cortex regionalization cell proliferation in forebrain forebrain cell migration cerebral cortex development neuron differentiation forebrain development response to drug sequence-specific DNA binding ureter morphogenesis uc008ibl.1 uc008ibl.2 uc008ibl.3 
ENSMUST00000062232.15 Nrl ENSMUST00000062232.15 neural retina leucine zipper gene, transcript variant 3 (from RefSeq NM_001271916.2) ENSMUST00000062232.1 ENSMUST00000062232.10 ENSMUST00000062232.11 ENSMUST00000062232.12 ENSMUST00000062232.13 ENSMUST00000062232.14 ENSMUST00000062232.2 ENSMUST00000062232.3 ENSMUST00000062232.4 ENSMUST00000062232.5 ENSMUST00000062232.6 ENSMUST00000062232.7 ENSMUST00000062232.8 ENSMUST00000062232.9 NM_001271916 Nrl Q543Y0 Q543Y0_MOUSE uc007tyu.1 uc007tyu.2 uc007tyu.3 uc007tyu.4 This gene encodes a member of the basic leucine zipper domain family of transcription factors. The encoded protein is preferentially expressed in the retina and is necessary for rod photoreceptor development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated regulation of rhodopsin gene expression leucine zipper domain binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter retinal rod cell development uc007tyu.1 uc007tyu.2 uc007tyu.3 uc007tyu.4 
ENSMUST00000062241.11 Tlr9 ENSMUST00000062241.11 toll-like receptor 9 (from RefSeq NM_031178.2) ENSMUST00000062241.1 ENSMUST00000062241.10 ENSMUST00000062241.2 ENSMUST00000062241.3 ENSMUST00000062241.4 ENSMUST00000062241.5 ENSMUST00000062241.6 ENSMUST00000062241.7 ENSMUST00000062241.8 ENSMUST00000062241.9 F8VPN5 NM_031178 Q4L0K3 Q4L0K4 Q99MF2 Q99MQ8 Q9EQU3 TLR9_MOUSE uc009rjh.1 uc009rjh.2 uc009rjh.3 Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:18931679, PubMed:21402738, PubMed:14993594, PubMed:17474149, PubMed:25686612, PubMed:18820679). Plays a role in defense against systemic mouse cytomegalovirus infection (PubMed:14993594). Controls lymphocyte response to Helicobacter infection (PubMed:17474149). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (By similarity). Interacts with MYD88 via their respective TIR domains (PubMed:18820679). Interacts with BTK (By similarity). Interacts (via transmembrane domain) with UNC93B1 (PubMed:17452530, PubMed:18931679). Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (PubMed:21940676). Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum (PubMed:18780723, PubMed:20865800). Interacts with SMPDL3B (PubMed:26095358). Q9EQU3; P11507: Atp2a2; Xeno; NbExp=4; IntAct=EBI-9979528, EBI-916319; Endoplasmic reticulum membrane ; Single-pass type I membrane protein Endosome sosome toplasmic vesicle, phagosome te=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (PubMed:18305481). Exit from the ER requires UNC93B1 (PubMed:18820679). Endolysosomal localization is required for proteolytic cleavage and subsequent activation (PubMed:18931679, PubMed:18820679). Intracellular localization of the active receptor may prevent from responding to self nucleic acid (PubMed:18820679). Expressed in the basolateral region of gastric epithelial cells with high levels detected in antrum and body mucosa (at protein level). Detected in spleen and stomach at higher levels in C57BL/6 mice than BALB/C. Following Helicobacter infection, down-regulated in C57BL/6 mice and up-regulated in BALB/C mice. Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain (PubMed:18931679, PubMed:18820679). Cleavage requires UNC93B1 (PubMed:18820679). Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling (PubMed:21402738). Reduced proliferation of lymphocytes, reduced interferon-gamma production by splenocytes and reduced neutrophil numbers following Helicobacter infection. Belongs to the Toll-like receptor family. microglial cell activation cytokine production regulation of protein phosphorylation activation of innate immune response toll-like receptor signaling pathway response to molecule of bacterial origin immune system process positive regulation of immunoglobulin production regulation of dendritic cell cytokine production MyD88-dependent toll-like receptor signaling pathway transmembrane signaling receptor activity interleukin-1 receptor binding protein binding cytoplasm lysosome endosome endoplasmic reticulum endoplasmic reticulum membrane plasma membrane inflammatory response immune response signal transduction I-kappaB kinase/NF-kappaB signaling I-kappaB phosphorylation signaling pattern recognition receptor activity male gonad development response to virus positive regulation of autophagy positive regulation of gene expression membrane integral component of membrane basolateral plasma membrane apical plasma membrane maintenance of gastrointestinal epithelium positive regulation of B cell proliferation cytoplasmic vesicle early phagosome negative regulation of NF-kappaB transcription factor activity tumor necrosis factor production negative regulation of interleukin-6 production negative regulation of interleukin-8 production positive regulation of chemokine production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway positive regulation of toll-like receptor signaling pathway toll-like receptor 9 signaling pathway regulation of toll-like receptor 9 signaling pathway positive regulation of toll-like receptor 9 signaling pathway siRNA binding endolysosome protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade positive regulation of JUN kinase activity positive regulation of interferon-gamma biosynthetic process innate immune response unmethylated CpG binding phagocytic vesicle positive regulation of interferon-alpha biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of interleukin-8 biosynthetic process regulation of B cell differentiation positive regulation of transcription from RNA polymerase II promoter regulation of cytokine secretion regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium regulation of B cell activation positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity defense response to virus positive regulation of nitric-oxide synthase biosynthetic process cellular response to lipopolysaccharide cellular response to metal ion positive regulation of NIK/NF-kappaB signaling negative regulation of calcium-transporting ATPase activity cellular response to chloroquine uc009rjh.1 uc009rjh.2 uc009rjh.3 
ENSMUST00000062246.8 Tnfsf15 ENSMUST00000062246.8 tumor necrosis factor (ligand) superfamily, member 15 (from RefSeq NM_177371.4) B2RR33 B2RR33_MOUSE E9PVT2 ENSMUST00000062246.1 ENSMUST00000062246.2 ENSMUST00000062246.3 ENSMUST00000062246.4 ENSMUST00000062246.5 ENSMUST00000062246.6 ENSMUST00000062246.7 F6VXB8 NM_177371 Tnfsf15 uc008thc.1 uc008thc.2 uc008thc.3 uc008thc.4 Belongs to the tumor necrosis factor family. cytokine activity tumor necrosis factor receptor binding extracellular region extracellular space apoptotic process immune response signal transduction membrane integral component of membrane uc008thc.1 uc008thc.2 uc008thc.3 uc008thc.4 
ENSMUST00000062248.3 Or7e173 ENSMUST00000062248.3 olfactory receptor family 7 subfamily E member 173 (from RefSeq NM_146558.2) ENSMUST00000062248.1 ENSMUST00000062248.2 NM_146558 Olfr866 Or7e173 Q8VFI7 Q8VFI7_MOUSE uc009ohz.1 uc009ohz.2 uc009ohz.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC119369.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ohz.1 uc009ohz.2 uc009ohz.3 
ENSMUST00000062254.4 Clec14a ENSMUST00000062254.4 C-type lectin domain family 14, member a (from RefSeq NM_025809.5) CLC14_MOUSE ENSMUST00000062254.1 ENSMUST00000062254.2 ENSMUST00000062254.3 NM_025809 Q3TP72 Q8VCP9 Q9CXA8 Q9D624 Q9DC55 uc007npv.1 uc007npv.2 uc007npv.3 uc007npv.4 Membrane ; Single-pass type I membrane protein cell migration involved in sprouting angiogenesis external side of plasma membrane membrane integral component of membrane cell migration carbohydrate binding extracellular matrix binding extracellular matrix protein binding uc007npv.1 uc007npv.2 uc007npv.3 uc007npv.4 
ENSMUST00000062264.8 Nucks1 ENSMUST00000062264.8 nuclear casein kinase and cyclin-dependent kinase substrate 1, transcript variant 1 (from RefSeq NM_175294.3) ENSMUST00000062264.1 ENSMUST00000062264.2 ENSMUST00000062264.3 ENSMUST00000062264.4 ENSMUST00000062264.5 ENSMUST00000062264.6 ENSMUST00000062264.7 NM_175294 NUCKS_MOUSE Nucks Q80XU3 Q8BVD8 uc007cny.1 uc007cny.2 uc007cny.3 uc007cny.4 Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1. Does not interact with RAD51. Nucleus Chromosome Phosphorylated in an ATM-dependent manner in response to DNA damage. Phosphorylated by CDK1 and casein kinase. double-strand break repair via homologous recombination chromatin nuclear chromatin transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cellular glucose homeostasis chromatin binding double-stranded DNA binding single-stranded DNA binding nucleus nucleolus cytoplasm regulation of DNA replication chromatin organization regulation of transcription from RNA polymerase II promoter transcription factor binding release from viral latency replication fork processing interstrand cross-link repair glucose homeostasis positive regulation by host of viral transcription positive regulation by host of viral genome replication positive regulation of transcription from RNA polymerase II promoter regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway regulation of DNA strand elongation cellular response to X-ray modulation by host of RNA binding by virus modulation by host of viral RNA-binding transcription factor activity uc007cny.1 uc007cny.2 uc007cny.3 uc007cny.4 
ENSMUST00000062289.11 Bend6 ENSMUST00000062289.11 BEN domain containing 6, transcript variant 1 (from RefSeq NM_177235.3) BEND6_MOUSE ENSMUST00000062289.1 ENSMUST00000062289.10 ENSMUST00000062289.2 ENSMUST00000062289.3 ENSMUST00000062289.4 ENSMUST00000062289.5 ENSMUST00000062289.6 ENSMUST00000062289.7 ENSMUST00000062289.8 ENSMUST00000062289.9 NM_177235 Q6PFX2 Q8BLC9 Q8BXN2 uc007aoc.1 uc007aoc.2 uc007aoc.3 uc007aoc.4 Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214, PubMed:25561495). Interacts (via BEN domain) with RBPJ. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PFX2-1; Sequence=Displayed; Name=2; IsoId=Q6PFX2-2; Sequence=VSP_026968, VSP_026969; Name=3; IsoId=Q6PFX2-3; Sequence=VSP_026967; Expressed in differentiating neurons in embryonic neocortex (at protein level). chromatin binding transcription corepressor activity nucleus nervous system development positive regulation of neuron differentiation negative regulation of Notch signaling pathway negative regulation of nucleic acid-templated transcription uc007aoc.1 uc007aoc.2 uc007aoc.3 uc007aoc.4 
ENSMUST00000062292.5 Foxc1 ENSMUST00000062292.5 forkhead box C1 (from RefSeq NM_008592.2) ENSMUST00000062292.1 ENSMUST00000062292.2 ENSMUST00000062292.3 ENSMUST00000062292.4 FOXC1_MOUSE Fkh1 Fkhl7 Freac3 Mf1 NM_008592 O88409 Q61572 Q61582 Q9QWR9 uc007pzp.1 uc007pzp.2 uc007pzp.3 DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:9635428, PubMed:9106663, PubMed:10479458, PubMed:10395790, PubMed:11562355, PubMed:18187037, PubMed:19668217, PubMed:22493429, PubMed:24590069, PubMed:25808752, PubMed:28223138). Acts either as a transcriptional activator or repressor (PubMed:28223138). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:25808752). Upon DNA-binding, promotes DNA bending. Acts as a transcriptional coactivator (PubMed:25808752). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (PubMed:25808752). Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells. Regulates FOXO1 through binding to a conserved element, 5'- GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (By similarity). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (PubMed:28223138). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (By similarity). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (PubMed:18187037). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (By similarity). Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage (PubMed:9106663, PubMed:10479458, PubMed:10395790, PubMed:10704385, PubMed:11562355, PubMed:15196959). Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC) (PubMed:24590069). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF- dependent manner (PubMed:22171010). May function as a tumor suppressor (By similarity). Monomer. Interacts with C1QBP (By similarity). Interacts (via N-terminus) with GLI2 (via C-terminal internal region); this interaction is direct and increases GLI2 DNA-binding and transcriptional activity through a smoothened (SMO)-independent Hedgehog (Hh) signaling pathway (PubMed:26565916, PubMed:25808752). Interacts (via C-terminus domain) with PITX2 (via homeobox domain) (By similarity). Interacts with FLNA and PBX1 (By similarity). Nucleus Note=Colocalizes with PITX2 in the nucleus at subnuclear chromatin regions. Colocalizes with CBX5 to a heterochromatin-rich region of the nucleus (By similarity). Colocalizes with GLI2 in the nucleus (PubMed:25808752). Expressed in glomerular epithelial cells, the podocytes (PubMed:28223138). Expressed in a population of adipo- osteogenic progenitor cells, termed CXCL12-abundant reticular (CAR) cells (at protein level) (PubMed:24590069). Expressed in many embryonic tissues, including prechondrogenic mesenchyme, periocular mesenchyme, meninges, endothelial cells and kidney (PubMed:9767123). Detected in adult brain, heart, kidney, adrenal gland, lung and testis, with lower levels in stomach, spleen and thymus (PubMed:9767123). Expressed in endothelial cells (PubMed:18187037). Expressed in the mesenchyme adjacent to the developing cerebellum (PubMed:19668217). Expressed in the sternum and rib cartilage (PubMed:25808752). Expressed in growth plate chondrocytes (PubMed:25808752). Expressed in the anterior presomitic mesoderm (PSM) and somites at 9.5 dpc. Expressed in endothelial and smooth muscle cells of blood vessels at 9.5 dpc (PubMed:11562355). Expressed in growth plate chondrocytes and perichondrial cells at 13.5 dpc (at protein level) (PubMed:25808752). Expressed in non-notochordal mesoderm surrounding the node and notochord at 7.5 dpc (PubMed:9106663). Expressed in anterior presomitic mesoderm adjacent to somites, in the somites, and in the cephalic mesoderm at 8.5 and 9.5 dpc (PubMed:9106663). Detected weakly in yolk sac at 9.5 dpc (PubMed:11562355). Expressed in presumptive intermediate mesoderm, as well as in the presomitic mesoderm and somites at 8.5 and 9.5 dpc (PubMed:10704385). Expressed in the metanephric mesenchyme of the kidney at 10.5 and 12.5 dpc (PubMed:10704385). Expressed during the developing cardiovascular system (PubMed:10479458). Expressed in the branchial arches and mesenchymal cells surrounding the eye at 10.5 dpc (PubMed:9106663). Expressed in nasal processes, corneal mesenchyme cells, branchial arches, blood vessels and endocardium at 11.5 dpc (PubMed:9106663, PubMed:10395790). Expressed in cells located in the presumptive anterior segment that are fated to contribute to the corneal endothelium or stroma, as well as within cells located at the periphery of the optic cup at 11.5 dpc (PubMed:16449236). Expressed in periocular mesenchyme cells at 11.5, 12.5 and 16.5 dpc (PubMed:10395790, PubMed:16449236). Expressed in developing limb buds at 12.5 dpc (PubMed:25808752). Expressed in chondrocytes at 15 dpc (PubMed:25808752). Expressed in the trabecular meshwork cells, the sclera, the conjunctival epithelium and the corneal epithelium at 16.5 dpc (PubMed:10395790). Strongly expressed in adipo-osteogenic progenitor cells (CXCL12-abundant reticular (CAR) cells) at 16.5 dpc and at birth (PubMed:24590069). Phosphorylated (PubMed:22493429). Phosphorylated on Ser-274 in response to epidermal growth factor (EGF) in a ERK1/2 MAPK-dependent signaling pathway; phosphorylation contributes to its protein stability and transcriptional regulatory activity (By similarity). Sumoylated preferentially with SUMO2 or SUMO3. Desumoylated by SENP2. Ubiquitinated, leading to its proteasomal degradation. Embryos die pre- and perinatally with haemorrhagic hydrocephalus and calvarial defects, beginning at 13.5 dpc (PubMed:9635428, PubMed:10479458, PubMed:19668217). Mutants that survive to later stages exhibit multiple craniofacial and vertebral defects characterized by disorganized rib fusion, absence of chondrocytes proliferation and ossification (PubMed:9106663, PubMed:25808752). Show abnormal cerebellar development with an enlarged fourth ventricle roof plate at 12.5 dpc and a disorganized cerebellar rhombic lip (PubMed:19668217). Show eye formation abnormalities: the lens remains attached to the cornea, both the anterior chamber and the corneal endothelium are absent, the corneal stroma is thicker, the arrangement of mesenchyme cells are disorganized and the corneal endothelial cells do not differentiate (PubMed:10395790). Show cardiovascular defects including persistent truncus arteriosus, ventricular septal defect, coarctation of the aortic arch, and aortic and pulmonary valve dysplasia (PubMed:10479458). Show abnormal kidney and ureter development, including duplex kidneys connecting to double ureters (PubMed:10704385). Show a decrease in hedgehog-induced genes expression levels involved in endochondral ossification (PubMed:25808752). Double knockout of FOXC1 and FOXC2 genes in mice embryos die around 8-9.5 dpc and show profound abnormalities in the first and second branchial arches, the early remodeling of blood vessels, a complete absence of segmented paraxial mesoderm, and the presence of ectopic and disorganized mesonephric kidney tubules (PubMed:11562355, PubMed:15196959). Mice with conditional knockout of both FOXC1 and FOXC2 genes in adult mice show renal tubular damage with protein reabsorption droplets, tubular dilation and proteinaceous casts and show also altered expression levels for several genes involved in the differentiation of podocytes (PubMed:28223138). Display also podocyte degeneration characterized with microvillous transformation, podocyte foot process effacement and irregular thickness of the glomerular basement membrane (PubMed:28223138). Podocyte-cell-specific conditional knockout of both FOXC1 and FOXC2 genes in adult mice show reabsorption droplets, tubular dilation and proteinaceous casts (PubMed:28223138). Endothelial-specific conditional knockout mice show a significant reduction in CXCR4 expression as well as in chemokine CXCL12-induced endothelial cell migration (PubMed:18187037). Limb bud mesenchymal-specific conditional knockout mice display strong reduction in haematopoietic stem and progenitor cells, the presence of adipocytes in marrow cavities (yellow adipose marrow) instead of CXCL12-abundant reticular (CAR) cells and die around 6 weeks of age with haemorrhagic hydrocephalus and calvarial defects (PubMed:24590069). CAR cell- specific conditional knockout mice are viable and die without hydrocephalus defects, but show a reduction in haematopoietic stem and progenitor cells (HSPCs) and most marrow cavities are filled with adipocytes (PubMed:24590069). Adult widespread cell-specific conditional knockout mice show a reduction in haematopoietic stem and progenitor cells (HSPCs), with only occasional adipocytes present in marrow cavities (PubMed:24590069). Neural crest (NC)-specific conditional knockout mice die postnatally with hydrocephalus and craniofacial abnormalities comparable to those seen in conventional knockout mice; embryos display pupillary abnormalities, with impaired collagen formation in the corneal stroma and aberrant vessel growth in the normally avascular corneas (PubMed:22171010). negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription coactivator binding skeletal system development ossification angiogenesis ovarian follicle development blood vessel development eye development ureteric bud development in utero embryonic development somitogenesis kidney development lymph vessel development endochondral ossification blood vessel remodeling heart morphogenesis DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity nucleus nucleoplasm nuclear heterochromatin cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Notch signaling pathway multicellular organism development brain development heart development transcription factor binding cell proliferation DNA binding, bending germ cell migration anatomical structure morphogenesis positive regulation of gene expression positive regulation of epithelial to mesenchymal transition mesenchymal cell development neural crest cell development cell migration negative regulation of angiogenesis cerebellum development cell differentiation collagen fibril organization glycosaminoglycan metabolic process lacrimal gland development embryonic heart tube development maintenance of lens transparency vascular endothelial growth factor signaling pathway odontogenesis of dentin-containing tooth camera-type eye development positive regulation of DNA binding sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of keratinocyte differentiation positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter regulation of organ growth vascular endothelial growth factor receptor signaling pathway paraxial mesoderm formation mesenchymal cell differentiation artery morphogenesis ventricular cardiac muscle tissue morphogenesis cardiac muscle cell proliferation chemokine-mediated signaling pathway cellular response to epidermal growth factor stimulus glomerular epithelium development regulation of blood vessel diameter negative regulation of lymphangiogenesis positive regulation of hematopoietic progenitor cell differentiation positive regulation of hematopoietic stem cell differentiation negative regulation of apoptotic process involved in outflow tract morphogenesis positive regulation of core promoter binding promoter-specific chromatin binding cellular response to chemokine uc007pzp.1 uc007pzp.2 uc007pzp.3 
ENSMUST00000062304.7 Lrrc4 ENSMUST00000062304.7 leucine rich repeat containing 4 (from RefSeq NM_138682.2) ENSMUST00000062304.1 ENSMUST00000062304.2 ENSMUST00000062304.3 ENSMUST00000062304.4 ENSMUST00000062304.5 ENSMUST00000062304.6 LRRC4_MOUSE NM_138682 Q149E5 Q8VI35 Q99PH1 uc009bcu.1 uc009bcu.2 uc009bcu.3 Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma. Interacts (via LRR repeats) with NTNG2. Interacts with DLG4. Forms a complex with DLG4 and with NMDA receptors. Membrane; Single-pass type I membrane protein. Postsynaptic cell membrane Note=LRRC4 and DLG4 are interdependent for synaptic localization. Specifically expressed in brain. In the hippocampus, parietal cortex and piriform cortex expressed in proximal segments of CA1 pyramidal neurons. The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4. N-glycosylated. Mutant mice dysplay impaired startle response to acoustic stimulus. protein binding plasma membrane membrane integral component of membrane cell junction dendritic spine neuron spine synapse postsynaptic membrane modulation of synaptic transmission synapse organization excitatory synapse postsynaptic density protein 95 clustering glutamatergic synapse integral component of postsynaptic density membrane synaptic membrane adhesion excitatory synapse assembly uc009bcu.1 uc009bcu.2 uc009bcu.3 
ENSMUST00000062306.7 Stpg2 ENSMUST00000062306.7 sperm tail PG rich repeat containing 2 (from RefSeq NM_198659.3) B2RQW3 ENSMUST00000062306.1 ENSMUST00000062306.2 ENSMUST00000062306.3 ENSMUST00000062306.4 ENSMUST00000062306.5 ENSMUST00000062306.6 NM_198659 Q8C8J0 STPG2_MOUSE uc008rny.1 uc008rny.2 molecular_function cellular_component biological_process uc008rny.1 uc008rny.2 
ENSMUST00000062307.5 Phf11a ENSMUST00000062307.5 PHD finger protein 11A (from RefSeq NM_172603.3) ENSMUST00000062307.1 ENSMUST00000062307.2 ENSMUST00000062307.3 ENSMUST00000062307.4 NM_172603 PH11A_MOUSE Phf11 Phf11-4 Phf11l Q8BVM9 uc007uee.1 uc007uee.2 uc007uee.3 Nucleus molecular_function nucleus nucleoplasm nuclear membrane metal ion binding regulation of immune response uc007uee.1 uc007uee.2 uc007uee.3 
ENSMUST00000062315.7 Tlr6 ENSMUST00000062315.7 toll-like receptor 6, transcript variant 1 (from RefSeq NM_011604.6) ENSMUST00000062315.1 ENSMUST00000062315.2 ENSMUST00000062315.3 ENSMUST00000062315.4 ENSMUST00000062315.5 ENSMUST00000062315.6 NM_011604 Q9EPW9 Q9WTQ4 TLR6_MOUSE uc008xmx.1 uc008xmx.2 uc008xmx.3 uc008xmx.4 Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:19931471). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low- density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:20037584, PubMed:23812099). Homodimer (via cytoplasmic TIR domain) (By similarity). Heterodimer with TLR2 via their respective extracellular domains (PubMed:19931471). Binds MYD88 via their respective TIR domains (Probable). Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4:TLR6 heterodimerization and signal initiation (By similarity). The heterodimer TLR2:TLR6 interacts with CD14 and CD36 in response to triacylated lipopeptides (By similarity). Cell membrane ; Single-pass type I membrane protein Cytoplasmic vesicle, phagosome membrane ; Single-pass type I membrane protein Membrane raft Golgi apparatus Note=Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. Detected in thymus, spleen, ovary and lung. Expressed in macrohpages. Animals with a double knockout of APOE and TLR6, fed a Western diet for 12 weeks, have less aortic plaque formation than single APOE knockout mice. They also show lower serum concentrations of IL1A, ILB and IL18. Belongs to the Toll-like receptor family. In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity. Sequence=AAG38563.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAA78632.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; microglial cell activation cell activation toll-like receptor signaling pathway immune system process MyD88-dependent toll-like receptor signaling pathway transmembrane signaling receptor activity receptor binding cell Golgi apparatus plasma membrane integral component of plasma membrane inflammatory response signal transduction positive regulation of gene expression membrane integral component of membrane phagocytic vesicle membrane cytoplasmic vesicle response to bacterial lipoprotein negative regulation of toll-like receptor 2 signaling pathway toll-like receptor 6 signaling pathway Toll-like receptor 2-Toll-like receptor 6 protein complex Toll-like receptor 2 binding TRIF-dependent toll-like receptor signaling pathway detection of diacyl bacterial lipopeptide diacyl lipopeptide binding identical protein binding positive regulation of macrophage activation positive regulation of I-kappaB kinase/NF-kappaB signaling receptor complex positive regulation of JUN kinase activity positive regulation of interleukin-12 biosynthetic process innate immune response membrane raft positive regulation of interleukin-6 biosynthetic process positive regulation of nitric oxide biosynthetic process nitric oxide metabolic process protein heterodimerization activity interleukin-1 beta secretion regulation of cytokine secretion positive regulation of inflammatory response positive regulation of NF-kappaB transcription factor activity lipopeptide binding cellular response to diacyl bacterial lipopeptide positive regulation of cytokine production involved in inflammatory response positive regulation of NLRP3 inflammasome complex assembly positive regulation of oxidative stress-induced neuron death positive regulation of reactive oxygen species biosynthetic process negative regulation of tumor necrosis factor secretion cellular response to beta-amyloid negative regulation of interleukin-8 secretion uc008xmx.1 uc008xmx.2 uc008xmx.3 uc008xmx.4 
ENSMUST00000062353.12 Or6b3 ENSMUST00000062353.12 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGU5) ENSMUST00000062353.1 ENSMUST00000062353.10 ENSMUST00000062353.11 ENSMUST00000062353.2 ENSMUST00000062353.3 ENSMUST00000062353.4 ENSMUST00000062353.5 ENSMUST00000062353.6 ENSMUST00000062353.7 ENSMUST00000062353.8 ENSMUST00000062353.9 Olfr1414 Or6b3 Q8VGU5 Q8VGU5_MOUSE uc007cbk.1 uc007cbk.2 uc007cbk.3 uc007cbk.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007cbk.1 uc007cbk.2 uc007cbk.3 uc007cbk.4 
ENSMUST00000062356.7 Marcksl1 ENSMUST00000062356.7 MARCKS-like 1 (from RefSeq NM_010807.4) ENSMUST00000062356.1 ENSMUST00000062356.2 ENSMUST00000062356.3 ENSMUST00000062356.4 ENSMUST00000062356.5 ENSMUST00000062356.6 MRP_MOUSE Mlp Mrp NM_010807 P28667 Q3TEZ4 Q91W07 uc008uxf.1 uc008uxf.2 uc008uxf.3 uc008uxf.4 Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (PubMed:22751924). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (PubMed:22751924). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (Probable). Binds to filamentous actin (F-actin), but not to monomeric G- actin, independently of its phosphorylation status (PubMed:22751924). Interacts with calmodulin (PubMed:1618855). Cytoplasm, cytoskeleton Cell membrane ; Lipid-anchor Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain (Probable). Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin (By similarity). Colocalizes with F-actin at the leading edge of migrating cells (PubMed:22751924). Expressed at high levels in brain cortex and hippocampus, including dentate gyrus, anterior olfactory nucleus, primary olfactory cortex, entorhinal cortex, medial preoptic area and dorsomedial hypothalamic nucleus (at protein level) (PubMed:1864362, PubMed:8406449, PubMed:9598313, PubMed:22751924). Expressed in neuronal cells (at protein level) (PubMed:22751924). Detected in the retina (PubMed:9598313). Strongly expressed in testis and uterus; expressed at lower levels in cerebellum, cerebrum, adipose tissue, spleen, kidney, thyroid, liver, lung, skeletal muscle and heart (PubMed:8406449). Detected in T-cells and B-cells (PubMed:8406449). Expressed in the developing neural tube as early as 8.5 dpc. Remains most highly expressed in the developing brain and spinal cord during later development at least until 14.5 dpc. Also detected in the lung, adrenal gland, gut and kidney, particularly the kidney cortex. Undetectable in the liver. Up-regulated in peritoneal macrophages in response to bacterial lipopolysaccharide (LPS). Phosphorylated (PubMed:1618855, PubMed:22751924). Phosphorylation at Ser-120 and Thr-183 is non-redundantly catalyzed by MAPK8 in vivo (PubMed:22751924). Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8 (PubMed:22751924). May be phosphorylated by protein kinase C, which disrupts the interaction with calmodulin (PubMed:1618855). Belongs to the MARCKS family. actin binding calmodulin binding cytoplasm cytoskeleton plasma membrane synaptic vesicle positive regulation of cell proliferation membrane anchored component of presynaptic membrane regulation of presynaptic cytosolic calcium ion concentration presynaptic cytosol voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels uc008uxf.1 uc008uxf.2 uc008uxf.3 uc008uxf.4 
ENSMUST00000062357.6 Bnip5 ENSMUST00000062357.6 BCL2 interacting protein 5 (from RefSeq NM_172450.3) B2KF61 BNIP5_MOUSE ENSMUST00000062357.1 ENSMUST00000062357.2 ENSMUST00000062357.3 ENSMUST00000062357.4 ENSMUST00000062357.5 NM_172450 Q148X2 Q8CC96 uc008bru.1 uc008bru.2 uc008bru.3 molecular_function cellular_component biological_process uc008bru.1 uc008bru.2 uc008bru.3 
ENSMUST00000062370.9 Wdr89 ENSMUST00000062370.9 WD repeat domain 89 (from RefSeq NM_028203.1) ENSMUST00000062370.1 ENSMUST00000062370.2 ENSMUST00000062370.3 ENSMUST00000062370.4 ENSMUST00000062370.5 ENSMUST00000062370.6 ENSMUST00000062370.7 ENSMUST00000062370.8 NM_028203 Q9D0R9 WDR89_MOUSE uc007nxj.1 uc007nxj.2 uc007nxj.3 uc007nxj.4 molecular_function cellular_component biological_process uc007nxj.1 uc007nxj.2 uc007nxj.3 uc007nxj.4 
ENSMUST00000062372.14 Reln ENSMUST00000062372.14 reelin, transcript variant 2 (from RefSeq NM_001310464.1) E9PZ78 ENSMUST00000062372.1 ENSMUST00000062372.10 ENSMUST00000062372.11 ENSMUST00000062372.12 ENSMUST00000062372.13 ENSMUST00000062372.2 ENSMUST00000062372.3 ENSMUST00000062372.4 ENSMUST00000062372.5 ENSMUST00000062372.6 ENSMUST00000062372.7 ENSMUST00000062372.8 ENSMUST00000062372.9 NM_001310464 Q60841 Q9CUA6 RELN_MOUSE Rl uc008wpi.1 uc008wpi.2 uc008wpi.3 Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2. Q60841; Q924X6: Lrp8; NbExp=4; IntAct=EBI-9248666, EBI-432319; Q60841; Q14114: LRP8; Xeno; NbExp=10; IntAct=EBI-9248666, EBI-2681187; Q60841; P98155: VLDLR; Xeno; NbExp=7; IntAct=EBI-9248666, EBI-9004309; Secreted, extracellular space, extracellular matrix. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q60841-1; Sequence=Displayed; Name=2; IsoId=Q60841-2; Sequence=VSP_005577; Name=3; IsoId=Q60841-3; Sequence=VSP_005578; The major isoform 1 is neuron-specific. It is abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. Expression is located in deeper layers in the developing hippocampus and olfactory bulb, low levels of expression are also detected in the immature striatum. At early developmental stages, expressed also in hypothalamic differentiation fields, tectum and spinal cord. A moderate to low level of expression occurs in the septal area, striatal fields, habenular nuclei, some thalamic nuclei, particularly the lateral geniculate, the retina and some nuclei of the reticular formation in the central field of the medulla. Very low levels found in liver and kidney. No expression in radial glial cells, cortical plate, Purkinje cells and inferior olivary neurons. The minor isoform 2 is only expressed in non neuronal cells. The minor isoform 3 is found in the same cells as isoform 1, but is almost undetectable in retina and brain stem. First detected at embryonic day 11.5. Expression increases up to birth and remains high from postnatal day 2 to 11 in both cerebellum and fore/midbrain. Expression declines thereafter and is largely brain specific in the adult. The basic C-terminal region is essential for secretion. N-glycosylated and to a lesser extent also O-glycosylated. Note=Defects in Reln are the cause of the autosomal recessive reeler (rl) phenotype which is characterized by impaired motor coordination, tremors and ataxia. Neurons in affected mice fail to reach their correct locations in the developing brain, disrupting the organization of the cerebellar and cerebral cortices and other laminated regions. Belongs to the reelin family. Sequence=BAA09788.1; Type=Erroneous initiation; Evidence=; cell morphogenesis involved in differentiation neuron migration extracellular matrix structural constituent protein binding extracellular region extracellular space cytoplasm plasma membrane proteolysis cell adhesion multicellular organism development axon guidance central nervous system development brain development learning long-term memory locomotory behavior peptidase activity serine-type peptidase activity associative learning glial cell differentiation regulation of gene expression positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase signaling dendrite development cell migration hydrolase activity peptidyl-tyrosine phosphorylation spinal cord patterning ventral spinal cord development dentate gyrus development hippocampus development cerebral cortex tangential migration layer formation in cerebral cortex cerebral cortex development axon dendrite forebrain development extracellular matrix positive regulation of TOR signaling positive regulation of CREB transcription factor activity protein localization to synapse reelin-mediated signaling pathway neuron projection neuronal cell body perikaryon positive regulation of protein kinase activity metal ion binding response to pain positive regulation of peptidyl-tyrosine phosphorylation regulation of behavior modulation of synaptic transmission positive regulation of small GTPase mediated signal transduction positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation positive regulation of dendritic spine morphogenesis positive regulation of protein tyrosine kinase activity lipoprotein particle receptor binding very-low-density lipoprotein particle receptor binding positive regulation of synapse maturation postsynaptic density assembly NMDA glutamate receptor clustering postsynaptic density protein 95 clustering receptor localization to synapse lateral motor column neuron migration positive regulation of long-term synaptic potentiation positive regulation of lateral motor column neuron migration regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc008wpi.1 uc008wpi.2 uc008wpi.3 
ENSMUST00000062387.8 Kcnj9 ENSMUST00000062387.8 potassium inwardly-rectifying channel, subfamily J, member 9, transcript variant 2 (from RefSeq NM_008429.3) ENSMUST00000062387.1 ENSMUST00000062387.2 ENSMUST00000062387.3 ENSMUST00000062387.4 ENSMUST00000062387.5 ENSMUST00000062387.6 ENSMUST00000062387.7 Kcnj9 NM_008429 Q544N3 Q544N3_MOUSE uc007dqg.1 uc007dqg.2 uc007dqg.3 Membrane ulti-pass membrane protein Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. inward rectifier potassium channel activity voltage-gated ion channel activity ion transport potassium ion transport G-protein activated inward rectifier potassium channel activity membrane integral component of membrane ion transmembrane transport regulation of ion transmembrane transport potassium ion transmembrane transport uc007dqg.1 uc007dqg.2 uc007dqg.3 
ENSMUST00000062405.8 Rasd1 ENSMUST00000062405.8 RAS, dexamethasone-induced 1 (from RefSeq NM_009026.5) ENSMUST00000062405.1 ENSMUST00000062405.2 ENSMUST00000062405.3 ENSMUST00000062405.4 ENSMUST00000062405.5 ENSMUST00000062405.6 ENSMUST00000062405.7 NM_009026 Q5SWR8 Q5SWR8_MOUSE Rasd1 uc007jfh.1 uc007jfh.2 uc007jfh.3 uc007jfh.4 This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF009246.1, BC034166.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Belongs to the small GTPase superfamily. RasD family. nucleotide binding GTPase activity GTP binding nucleus cytoplasm signal transduction nitric oxide mediated signal transduction membrane negative regulation of transcription, DNA-templated perinuclear region of cytoplasm uc007jfh.1 uc007jfh.2 uc007jfh.3 uc007jfh.4 
ENSMUST00000062407.6 Or4g17 ENSMUST00000062407.6 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF29) ENSMUST00000062407.1 ENSMUST00000062407.2 ENSMUST00000062407.3 ENSMUST00000062407.4 ENSMUST00000062407.5 Olfr1279 Olfr1284 Or4g17 Q8VF29 Q8VF29_MOUSE uc008lnl.1 uc008lnl.2 uc008lnl.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008lnl.1 uc008lnl.2 uc008lnl.3 
ENSMUST00000062428.5 Zfp784 ENSMUST00000062428.5 zinc finger protein 784 (from RefSeq NM_001039532.2) ENSMUST00000062428.1 ENSMUST00000062428.2 ENSMUST00000062428.3 ENSMUST00000062428.4 NM_001039532 Q8BI69 ZN784_MOUSE Znf784 uc009ezn.1 uc009ezn.2 uc009ezn.3 uc009ezn.4 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. hematopoietic progenitor cell differentiation nucleic acid binding DNA binding nucleus metal ion binding uc009ezn.1 uc009ezn.2 uc009ezn.3 uc009ezn.4 
ENSMUST00000062437.10 Nkx2-6 ENSMUST00000062437.10 NK2 homeobox 6, transcript variant 1 (from RefSeq NM_010920.2) ENSMUST00000062437.1 ENSMUST00000062437.2 ENSMUST00000062437.3 ENSMUST00000062437.4 ENSMUST00000062437.5 ENSMUST00000062437.6 ENSMUST00000062437.7 ENSMUST00000062437.8 ENSMUST00000062437.9 NKX26_MOUSE NM_010920 Nkx-2.6 Nkx2f P43688 uc007umc.1 uc007umc.2 uc007umc.3 uc007umc.4 Acts as a transcriptional activator (By similarity). In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development (PubMed:10733590, PubMed:11390666). Nucleus Not detected in any neonate or adult tissues. Expressed in developing gut endoderm, cardiac progenitors and heart. Expression restricted to the very narrow development period between stages 8.0 and 11.5 dpc. First detected at 8.0 dpc in the endoderm of the lateral walls and lip of the forming foregut pocket, directly juxtaposed to cardiogenic mesoderm. At 8.5 dpc, expressed in the forming pharynx, predominantly in its lateral aspects where pouches will form. From 8.5 to 11.5 dpc, expressed in the ventrolateral endoderm of all forming pouches, as well as in juxtaposed arch ectoderm and mesenchyme. Expression levels decrease as pouches matured. Also expressed in the ventral hindgut endoderm from 9.5 dpc and in a short segment at the foregut-midgut junction spanning the proximal parts of the common bile and pancreatic ducts. No visible phenotype; possibly due to the redundancy with NKX2-6. Mutant mice are viable and fertile. No obvious abnormalities in the caudal pharyngeal pouch derivatives (thymus, parathyroid glands, and thyroid gland), heart and gut. In NKX2-5 and NKX2-6 double mutants, the pharynx does not form properly and the development of the atrium is less advanced. Belongs to the NK-2 homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development heart development positive regulation of cell proliferation hypothalamus development cell differentiation embryonic heart tube development negative regulation of apoptotic process sequence-specific DNA binding tongue development positive regulation of transcription from RNA polymerase II promoter digestive tract development atrial cardiac muscle cell development ventricular cardiac muscle cell development pharyngeal system development pericardium development uc007umc.1 uc007umc.2 uc007umc.3 uc007umc.4 
ENSMUST00000062439.6 Ccdc54 ENSMUST00000062439.6 coiled-coil domain containing 54 (from RefSeq NM_027046.4) CCD54_MOUSE ENSMUST00000062439.1 ENSMUST00000062439.2 ENSMUST00000062439.3 ENSMUST00000062439.4 ENSMUST00000062439.5 NM_027046 Q9DAL3 uc007zkx.1 uc007zkx.2 uc007zkx.3 molecular_function cellular_component biological_process uc007zkx.1 uc007zkx.2 uc007zkx.3 
ENSMUST00000062463.4 Tas2r118 ENSMUST00000062463.4 taste receptor, type 2, member 118 (from RefSeq NM_207022.1) ENSMUST00000062463.1 ENSMUST00000062463.2 ENSMUST00000062463.3 NM_207022 P59529 Q7M728 T2R16_MOUSE Tas2r16 Tas2r18 uc009bbn.1 uc009bbn.2 Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). Interacts with RTP3 and RTP4. Cell membrane ; Multi-pass membrane protein Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity endoplasmic reticulum trans-Golgi network plasma membrane signal transduction G-protein coupled receptor signaling pathway external side of plasma membrane membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009bbn.1 uc009bbn.2 
ENSMUST00000062474.5 Cyp8b1 ENSMUST00000062474.5 cytochrome P450, family 8, subfamily b, polypeptide 1 (from RefSeq NM_010012.3) A0A0R4J0N7 A0A0R4J0N7_MOUSE Cyp8b1 ENSMUST00000062474.1 ENSMUST00000062474.2 ENSMUST00000062474.3 ENSMUST00000062474.4 NM_010012 uc009sef.1 uc009sef.2 uc009sef.3 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane sterol 12-alpha-hydroxylase activity membrane oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc009sef.1 uc009sef.2 uc009sef.3 
ENSMUST00000062483.15 Gli2 ENSMUST00000062483.15 GLI-Kruppel family member GLI2 (from RefSeq NM_001081125.1) E9PYJ4 ENSMUST00000062483.1 ENSMUST00000062483.10 ENSMUST00000062483.11 ENSMUST00000062483.12 ENSMUST00000062483.13 ENSMUST00000062483.14 ENSMUST00000062483.2 ENSMUST00000062483.3 ENSMUST00000062483.4 ENSMUST00000062483.5 ENSMUST00000062483.6 ENSMUST00000062483.7 ENSMUST00000062483.8 ENSMUST00000062483.9 GLI2_MOUSE Gli2 NM_001081125 Q0VGT2 Thp uc007cim.1 uc007cim.2 uc007cim.3 Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:9006072). Functions as a transcriptional activator (PubMed:10806483). May also function as transcriptional repressor (PubMed:10433919). Requires STK36 for full transcriptional activator activity (PubMed:10806483). Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element (By similarity). Is involved in the smoothened (SHH) signaling pathway (PubMed:10433919). Required for normal skeleton development (PubMed:9006072). Interacts with ZIC1 and ZIC2 (PubMed:11238441). Interacts with STK36 (PubMed:10806483). Interacts with SUFU; this inhibits transcriptional activation mediated by GLI2 (PubMed:10806483, PubMed:23034632). Interacts (via C-terminal internal region) with FOXC1 (via N-terminus); this interaction is direct and increases GLI2 DNA- binding and transcriptional activity through a smoothened (SMO)- independent Hedgehog (Hh) signaling pathway (PubMed:26565916, PubMed:25808752). Q0VGT2; Q6ZWS8: Spop; NbExp=2; IntAct=EBI-9344284, EBI-7128920; Q0VGT2; Q9UMX1: SUFU; Xeno; NbExp=3; IntAct=EBI-9344284, EBI-740595; Nucleus Cytoplasm Cell projection, cilium Note=STK36 promotes translocation to the nucleus (PubMed:10806483). In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus (PubMed:23034632). The N-terminal domain confers transcriptional repressor activity, while the C-terminal domain mediates transcriptional activation. Phosphorylated in vitro by ULK3. Phosphorylated by DYRK2; this inhibits GLI2 transcription factor activity and promotes proteasomal degradation of GLI2. Acetylation at Lys-740 inhibits Hh target gene expression, probably by impeding entry into chromatin thus preventing promoter occupancy. Full embryonic lethality. Homozygous embryos are detected at the expected Mendelian rate up to about 18.5 dpc, but there are no live pups. Mutant embryos present important craniofacial defects, including defects of the medial portion of the frontal and parietal skull bones, absence of upper and/or lower incisors, often combined with a cleft palate. Besides, mutant embryos show defects in the ossification of skeletal bones and shortened limb bones. Belongs to the GLI C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development osteoblast differentiation in utero embryonic development kidney development morphogenesis of an epithelium chondrocyte differentiation osteoblast development nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol cilium axoneme smoothened signaling pathway multicellular organism development pattern specification process axon guidance ventral midline development hindgut morphogenesis heart development transcription factor binding zinc ion binding cell proliferation positive regulation of cell proliferation epidermal cell differentiation anterior/posterior pattern specification dorsal/ventral pattern formation proximal/distal pattern formation membrane nuclear speck floor plate formation spinal cord dorsal/ventral patterning ventral spinal cord development spinal cord motor neuron differentiation cerebellar cortex morphogenesis smoothened signaling pathway involved in ventral spinal cord interneuron specification smoothened signaling pathway involved in spinal cord motor neuron cell fate specification dorsal/ventral neural tube patterning neural tube development smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation spinal cord ventral commissure morphogenesis pituitary gland development cell differentiation lung development mammary gland development hindbrain development motile cilium negative regulation of chondrocyte differentiation tube development odontogenesis of dentin-containing tooth embryonic digit morphogenesis cell projection negative regulation of apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of neuron differentiation positive regulation of DNA replication positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding embryonic digestive tract development developmental growth anatomical structure formation involved in morphogenesis neuron development branching morphogenesis of an epithelial tube anatomical structure development notochord regression head development prostatic bud formation mammary gland duct morphogenesis smoothened signaling pathway involved in dorsal/ventral neural tube patterning cellular response to organic cyclic compound cochlea morphogenesis ciliary tip cellular response to virus promoter-specific chromatin binding uc007cim.1 uc007cim.2 uc007cim.3 
ENSMUST00000062519.14 Crebrf ENSMUST00000062519.14 CREB3 regulatory factor (from RefSeq NM_029870.2) B8JJI1 CRERF_MOUSE ENSMUST00000062519.1 ENSMUST00000062519.10 ENSMUST00000062519.11 ENSMUST00000062519.12 ENSMUST00000062519.13 ENSMUST00000062519.2 ENSMUST00000062519.3 ENSMUST00000062519.4 ENSMUST00000062519.5 ENSMUST00000062519.6 ENSMUST00000062519.7 ENSMUST00000062519.8 ENSMUST00000062519.9 NM_029870 Q14DI2 Q8C8N7 Q8CDG5 Q9CTQ7 uc008bel.1 uc008bel.2 uc008bel.3 uc008bel.4 uc008bel.5 Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci (By similarity). Interacts (via leucine-zipper domain) with CREB3 (via leucine- zipper domain); the interaction promotes CREB3 degradation. Nucleus Note=Colocalizes with CREB3 in nuclear foci. Highly expressed in intestin, testis, heart and kidney, weakly in brain adipose, colon, liver, lung and skeletal. Probably degraded by the proteasome. Belongs to the bZIP family. CREBRF subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated response to unfolded protein nuclear body positive regulation of intracellular transport response to endoplasmic reticulum stress maternal behavior positive regulation of protein catabolic process positive regulation of transcription from RNA polymerase II promoter positive regulation of protein transport negative regulation of endoplasmic reticulum unfolded protein response negative regulation of glucocorticoid mediated signaling pathway positive regulation of prolactin signaling pathway uc008bel.1 uc008bel.2 uc008bel.3 uc008bel.4 uc008bel.5 
ENSMUST00000062524.6 Krtap20-21 ENSMUST00000062524.6 predicted gene 9789 (from RefSeq NM_001357999.1) ENSMUST00000062524.1 ENSMUST00000062524.2 ENSMUST00000062524.3 ENSMUST00000062524.4 ENSMUST00000062524.5 Gm9789 MGC58416 NM_001357999 Q8BIG3 Q8BIG3_MOUSE uc289fvz.1 uc289fvz.2 Interacts with hair keratins. molecular_function cellular_component biological_process uc289fvz.1 uc289fvz.2 
ENSMUST00000062525.11 Rnf149 ENSMUST00000062525.11 ring finger protein 149 (from RefSeq NM_001033135.3) E9QAH5 ENSMUST00000062525.1 ENSMUST00000062525.10 ENSMUST00000062525.2 ENSMUST00000062525.3 ENSMUST00000062525.4 ENSMUST00000062525.5 ENSMUST00000062525.6 ENSMUST00000062525.7 ENSMUST00000062525.8 ENSMUST00000062525.9 Greul4 NM_001033135 Q14BF0 Q3U2C5 Q8CGR2 RN149_MOUSE uc007atl.1 uc007atl.2 uc007atl.3 uc007atl.4 uc007atl.5 E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U2C5-1; Sequence=Displayed; Name=2; IsoId=Q3U2C5-2; Sequence=VSP_021734; The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. protein binding ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination transferase activity regulation of protein stability cellular response to drug negative regulation of MAPK cascade metal ion binding ubiquitin protein ligase activity uc007atl.1 uc007atl.2 uc007atl.3 uc007atl.4 uc007atl.5 
ENSMUST00000062528.9 Cdh20 ENSMUST00000062528.9 cadherin 20, transcript variant 1 (from RefSeq NM_011800.6) CAD20_MOUSE Cdh7 ENSMUST00000062528.1 ENSMUST00000062528.2 ENSMUST00000062528.3 ENSMUST00000062528.4 ENSMUST00000062528.5 ENSMUST00000062528.6 ENSMUST00000062528.7 ENSMUST00000062528.8 NM_011800 Q9Z0M3 uc007cgc.1 uc007cgc.2 uc007cgc.3 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). Cell membrane ; Single-pass type I membrane protein Expressed in brain. Highest level of expression in the retina. In embryo it is synthesized by the forebrain, anterior neural ridge, developing visual system, primitive external granular layer of the cerebellum and a subset of neural crest cells likely to develop into melanoblasts. Expressed during embryogenesis. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane metal ion binding cell-cell adhesion uc007cgc.1 uc007cgc.2 uc007cgc.3 
ENSMUST00000062530.5 Hexim2 ENSMUST00000062530.5 hexamethylene bis-acetamide inducible 2, transcript variant 1 (from RefSeq NM_027658.2) ENSMUST00000062530.1 ENSMUST00000062530.2 ENSMUST00000062530.3 ENSMUST00000062530.4 HEXI2_MOUSE NM_027658 Q3TVI4 Q9D4C7 uc007ltr.1 uc007ltr.2 uc007ltr.3 uc007ltr.4 Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Homooligomer and heterooligomer with HEXIM1; probably dimeric. Core component of the 7SK RNP complex, at least composed of 7SK RNA, LARP7, MEPCE, HEXIM1 (or HEXIM2) and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1). Interacts with CCNT2. Nucleus The coiled-coil domain mediates oligomerization. Belongs to the HEXIM family. Sequence=BAB30344.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter cyclin-dependent protein serine/threonine kinase inhibitor activity nucleus nucleoplasm cytoplasm cytosol nuclear speck snRNA binding identical protein binding negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated 7SK snRNA binding uc007ltr.1 uc007ltr.2 uc007ltr.3 uc007ltr.4 
ENSMUST00000062534.5 Or11h6 ENSMUST00000062534.5 olfactory receptor family 11 subfamily H member 6 (from RefSeq NM_146299.2) ENSMUST00000062534.1 ENSMUST00000062534.2 ENSMUST00000062534.3 ENSMUST00000062534.4 NM_146299 Olfr745 Or11h6 Q7TRL9 Q7TRL9_MOUSE uc007tlh.1 uc007tlh.2 uc007tlh.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC132579.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007tlh.1 uc007tlh.2 uc007tlh.3 
ENSMUST00000062535.2 Or8c13 ENSMUST00000062535.2 olfactory receptor family 8 subfamily C member 13 (from RefSeq NM_146478.2) E9Q843 E9Q843_MOUSE ENSMUST00000062535.1 NM_146478 Olfr891 Or8c13 uc009ovz.1 uc009ovz.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ovz.1 uc009ovz.2 
ENSMUST00000062560.14 Lgsn ENSMUST00000062560.14 lengsin, lens protein with glutamine synthetase domain (from RefSeq NM_153601.1) ENSMUST00000062560.1 ENSMUST00000062560.10 ENSMUST00000062560.11 ENSMUST00000062560.12 ENSMUST00000062560.13 ENSMUST00000062560.2 ENSMUST00000062560.3 ENSMUST00000062560.4 ENSMUST00000062560.5 ENSMUST00000062560.6 ENSMUST00000062560.7 ENSMUST00000062560.8 ENSMUST00000062560.9 Gluld1 LGSN_MOUSE Lgs NM_153601 Q149K1 Q8CIX8 uc007ank.1 uc007ank.2 uc007ank.3 May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity. Dodecamer. Interacts with BFSP2 and VIM. Expressed in lens. Belongs to the glutamine synthetase family. catalytic activity protein binding plasma membrane nitrogen compound metabolic process membrane glutamate-ammonia ligase activity glutamine biosynthetic process nitrogen utilization uc007ank.1 uc007ank.2 uc007ank.3 
ENSMUST00000062562.7 Apol7c ENSMUST00000062562.7 apolipoprotein L 7c (from RefSeq NM_175391.4) Apol7c ENSMUST00000062562.1 ENSMUST00000062562.2 ENSMUST00000062562.3 ENSMUST00000062562.4 ENSMUST00000062562.5 ENSMUST00000062562.6 NM_175391 Q8C6E1 Q8C6E1_MOUSE uc007wns.1 uc007wns.2 uc007wns.3 Belongs to the apolipoprotein L family. cellular_component extracellular region lipid transport lipid binding lipoprotein metabolic process uc007wns.1 uc007wns.2 uc007wns.3 
ENSMUST00000062572.3 Fzd9 ENSMUST00000062572.3 frizzled class receptor 9 (from RefSeq NM_010246.1) ENSMUST00000062572.1 ENSMUST00000062572.2 FZD9_MOUSE Fzd3 NM_010246 O35494 Q9CX16 Q9R216 Q9R2B3 uc008zya.1 uc008zya.2 uc008zya.3 uc008zya.4 Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (PubMed:24860427). May play a role in neural progenitor cells (NPCs) viability through the beta- catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (By similarity). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death (PubMed:15930120). Controls bone formation through non canonical Wnt signaling mediated via ISG15 (PubMed:21402791). Positively regulates bone regeneration through non canonical Wnt signaling (PubMed:24391920). Cell membrane ; Multi-pass membrane protein Note=Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. In the embryo, found in the neural tube, trunk skeletal muscle precursors (myotomes), limb skeletal anlagen, craniofacial regions and nephric ducts. In the adult, expression is abundant in heart, brain, testis and skeletal muscle. In the testis, expressed in all spermatogenic cell types. Lower levels in adult lung, liver and kidney. Barely detectable in spleen. Expressed also in chondrocytes. Not detected at 7 dpc, weakly at 11 dpc and strongly at 15 dpc and 17 dpc. Expression covers the entire neural tube at 9.5 dpc, decreases at 10.5 dpc and becomes detectable only in the lumbar to tail regions at 11.5 dpc. In the somites, expression begins at 10.5 dpc to become up-regulated all along the rostrocaudal trunk axis at 11.5 dpc. In craniofacial territories, expression is first detected at 11.5 dpc in restricted areas of the nose, the maxillar mandibular and second branchial arch anlagen. At 11.5 dpc, predominantly expressed in restricted areas of the nose, dorsally to the eye and in the caudal pharyngeal region. Highly expressed at early stages of neuromuscular junction assembly (14.5 dpc) and gradually decreases as development proceeds, being more than about 4-fold less expressed in 19.5 dpc. Increases during the initial stages of osteoblast differentiation. Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. The FZ domain is involved in binding with Wnt ligands. Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. Homozygous Fzd9 knockout mice show deficits in spatial memory behaviors. Heterozygous and homozygous Fzd9 knockout mice appear healthy, develop normally, and are fertile (PubMed:15930120). Homozygous Fzd9 knockout mice display osteopenia (PubMed:21402791). Belongs to the G-protein coupled receptor Fz/Smo family. Has been first described as FZD3 in literature. ossification release of cytochrome c from mitochondria transmembrane signaling receptor activity G-protein coupled receptor activity cytoplasm endoplasmic reticulum membrane Golgi apparatus plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway multicellular organism development neuroblast proliferation learning or memory cell surface membrane integral component of membrane Wnt signaling pathway Wnt-protein binding B cell differentiation positive regulation of bone mineralization filopodium membrane mitochondrial membrane non-canonical Wnt signaling pathway protein homodimerization activity Wnt-activated receptor activity positive regulation of apoptotic process negative regulation of neuron apoptotic process protein heterodimerization activity perinuclear region of cytoplasm regulation of cytosolic calcium ion concentration negative regulation of mitochondrial depolarization canonical Wnt signaling pathway negative regulation of necroptotic process negative regulation of cell cycle arrest positive regulation of canonical Wnt signaling pathway postsynapse glutamatergic synapse regulation of postsynaptic cytosolic calcium ion concentration negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of skeletal muscle acetylcholine-gated channel clustering negative regulation of skeletal muscle acetylcholine-gated channel clustering bone regeneration positive regulation of neural precursor cell proliferation uc008zya.1 uc008zya.2 uc008zya.3 uc008zya.4 
ENSMUST00000062580.8 Itsn2 ENSMUST00000062580.8 intersectin 2, transcript variant 2 (from RefSeq NM_011365.4) E9QNG1 E9QNG1_MOUSE ENSMUST00000062580.1 ENSMUST00000062580.2 ENSMUST00000062580.3 ENSMUST00000062580.4 ENSMUST00000062580.5 ENSMUST00000062580.6 ENSMUST00000062580.7 Itsn2 NM_011365 uc007mxx.1 uc007mxx.2 uc007mxx.3 Cytoplasm Rho guanyl-nucleotide exchange factor activity calcium ion binding centrosome endocytosis regulation of Rho protein signal transduction positive regulation of dendrite extension uc007mxx.1 uc007mxx.2 uc007mxx.3 
ENSMUST00000062586.3 Defb15 ENSMUST00000062586.3 defensin beta 15 (from RefSeq NM_139222.4) A2A4E5 DFB15_MOUSE ENSMUST00000062586.1 ENSMUST00000062586.2 NM_139222 Q8R2I5 uc009lce.1 uc009lce.2 uc009lce.3 Has antibacterial activity. Secreted Expressed in testis and to a lesser extent in epididymis (caput, corpus and cauda). Also weakly expressed in kidneys and colon. Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium innate immune response uc009lce.1 uc009lce.2 uc009lce.3 
ENSMUST00000062606.8 Upk3b ENSMUST00000062606.8 uroplakin 3B (from RefSeq NM_175309.4) A0A0R4J0S8 A0A0R4J0S8_MOUSE ENSMUST00000062606.1 ENSMUST00000062606.2 ENSMUST00000062606.3 ENSMUST00000062606.4 ENSMUST00000062606.5 ENSMUST00000062606.6 ENSMUST00000062606.7 NM_175309 Upk3b uc008zzq.1 uc008zzq.2 uc008zzq.3 negative regulation of gene expression membrane integral component of membrane uc008zzq.1 uc008zzq.2 uc008zzq.3 
ENSMUST00000062609.6 Zkscan4 ENSMUST00000062609.6 zinc finger with KRAB and SCAN domains 4 (from RefSeq NM_001039115.2) ENSMUST00000062609.1 ENSMUST00000062609.2 ENSMUST00000062609.3 ENSMUST00000062609.4 ENSMUST00000062609.5 NM_001039115 Q5SZT6 Q5SZT6_MOUSE Zkscan4 uc007pqn.1 uc007pqn.2 uc007pqn.3 uc007pqn.4 uc007pqn.5 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc007pqn.1 uc007pqn.2 uc007pqn.3 uc007pqn.4 uc007pqn.5 
ENSMUST00000062613.12 Tdrp ENSMUST00000062613.12 testis development related protein, transcript variant 2 (from RefSeq NM_173744.5) ENSMUST00000062613.1 ENSMUST00000062613.10 ENSMUST00000062613.11 ENSMUST00000062613.2 ENSMUST00000062613.3 ENSMUST00000062613.4 ENSMUST00000062613.5 ENSMUST00000062613.6 ENSMUST00000062613.7 ENSMUST00000062613.8 ENSMUST00000062613.9 NM_173744 Q3TQC8 Q8C5P7 TDRP_MOUSE uc009kyv.1 uc009kyv.2 uc009kyv.3 Contributes to normal sperm motility, but not essential for male fertility. Interacts with PRM2. Nucleus Cytoplasm Note=Mainly nuclear. Also detected in cytoplasm near the midpiece of the flagellum. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C5P7-1; Sequence=Displayed; Name=2; IsoId=Q8C5P7-2; Sequence=VSP_028924; Strongly expressed in testis. Also detected at lower levels in epididymis, bone marrow and kidney. Viable with no gross morphological defects. Morphology of testis tissue and mature epididymal sperm is normal. Sperm counts are also normal. Sperm motility is reduced, however this has no significant effect on male fertility. Belongs to the TDRP family. molecular_function cellular_component nucleus cytoplasm cytosol spermatogenesis biological_process intracellular membrane-bounded organelle uc009kyv.1 uc009kyv.2 uc009kyv.3 
ENSMUST00000062620.9 Hamp ENSMUST00000062620.9 hepcidin antimicrobial peptide (from RefSeq NM_032541.2) ENSMUST00000062620.1 ENSMUST00000062620.2 ENSMUST00000062620.3 ENSMUST00000062620.4 ENSMUST00000062620.5 ENSMUST00000062620.6 ENSMUST00000062620.7 ENSMUST00000062620.8 HEPC_MOUSE Hamp1 Hepc Hepc1 NM_032541 Q9EQ21 uc009ghf.1 uc009ghf.2 uc009ghf.3 uc009ghf.4 This gene encodes hepcidin, an antimicrobial peptide and master hormonal regulator of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature peptides that are secreted into the bloodstream. Mice lacking the encoded protein develop multivisceral iron overlaod, with sparing of the spleen macrophages. Certain mutations in the human ortholog of this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis. This gene is located adjacent to a related hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016]. Sequence Note: An in-frame AUG is located 1 codon upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB950373.1, CB951177.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. Interacts with SLC40A1; this interaction promotes SLC40A1 rapid ubiquitination. Secreted Highly expressed in the liver and to a much lesser extent in the heart. Secreted in blood (PubMed:15124018). Regulated in response to changes in circulating iron concentrations, iron stores or the development of inflammation and iron-restricted erythropoiesis. Down-regulated following anemia induced by hemorrhage or hemolysis: down-regulation is mediated by ERFE (PubMed:12370282, PubMed:24880340, PubMed:15124018). The induction of upon inflammation is mediated by IL6 (PubMed:15124018). Belongs to the hepcidin family. negative regulation of transcription from RNA polymerase II promoter myeloid cell homeostasis hormone activity copper ion binding extracellular region extracellular space nucleus cellular iron ion homeostasis JAK-STAT cascade cellular response to extracellular stimulus negative regulation of iron ion transmembrane transport defense response to bacterium positive regulation of macrophage activation negative regulation of bone resorption positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response defense response to fungus iron ion homeostasis positive regulation of cellular protein catabolic process uc009ghf.1 uc009ghf.2 uc009ghf.3 uc009ghf.4 
ENSMUST00000062623.4 Tigd4 ENSMUST00000062623.4 tigger transposable element derived 4 (from RefSeq NM_207278.2) ENSMUST00000062623.1 ENSMUST00000062623.2 ENSMUST00000062623.3 NM_207278 Q8BUZ3 TIGD4_MOUSE uc008pqh.1 uc008pqh.2 Nucleus Belongs to the tigger transposable element derived protein family. molecular_function nucleic acid binding DNA binding cellular_component nucleus biological_process uc008pqh.1 uc008pqh.2 
ENSMUST00000062626.4 Tigd2 ENSMUST00000062626.4 tigger transposable element derived 2 (from RefSeq NM_001081145.1) ENSMUST00000062626.1 ENSMUST00000062626.2 ENSMUST00000062626.3 NM_001081145 Q0VBL1 Q505P7 Q6NV77 TIGD2_MOUSE uc009cdj.1 uc009cdj.2 Nucleus Belongs to the tigger transposable element derived protein family. molecular_function nucleic acid binding DNA binding cellular_component nucleus biological_process uc009cdj.1 uc009cdj.2 
ENSMUST00000062629.5 Npm2 ENSMUST00000062629.5 nucleophosmin/nucleoplasmin 2, transcript variant 1 (from RefSeq NM_181345.4) ENSMUST00000062629.1 ENSMUST00000062629.2 ENSMUST00000062629.3 ENSMUST00000062629.4 NM_181345 NPM2_MOUSE Q80W85 Q8BW23 uc007uot.1 uc007uot.2 uc007uot.3 Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization. Homopentamer, when bound to H2A-H2B dimers only. Homodecamer of two stacked pentamers, when bound to H2A-H2B dimers and H3-H4 tetramers simultaneously (By similarity). Nucleus Note=Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm. Ovary specific. The acidic tract A2 mediates histone binding. Belongs to the nucleoplasmin family. cytoplasmic chromatin nuclear chromatin blastocyst development chromatin binding nucleus nucleoplasm nucleolus cytoplasm chromatin organization chromatin remodeling regulation of exit from mitosis multicellular organism development single fertilization oocyte differentiation enzyme binding histone binding positive regulation of catalytic activity positive regulation of DNA replication positive regulation of meiotic nuclear division positive regulation of DNA metabolic process protein homooligomerization uc007uot.1 uc007uot.2 uc007uot.3 
ENSMUST00000062638.8 Fam243 ENSMUST00000062638.8 family with sequence similarity 243 (from RefSeq NM_029252.2) ENSMUST00000062638.1 ENSMUST00000062638.2 ENSMUST00000062638.3 ENSMUST00000062638.4 ENSMUST00000062638.5 ENSMUST00000062638.6 ENSMUST00000062638.7 FA243_MOUSE Fam243 Fam243a NM_029252 Q8CDS7 uc007zyz.1 uc007zyz.2 uc007zyz.3 Belongs to the FAM243 family. molecular_function cellular_component biological_process uc007zyz.1 uc007zyz.2 uc007zyz.3 
ENSMUST00000062657.5 Ly6g5b ENSMUST00000062657.5 lymphocyte antigen 6 family member G5B, transcript variant 1 (from RefSeq NM_148939.3) ENSMUST00000062657.1 ENSMUST00000062657.2 ENSMUST00000062657.3 ENSMUST00000062657.4 LY65B_MOUSE NM_148939 Q3U982 Q8K1T4 uc008cfs.1 uc008cfs.2 uc008cfs.3 uc008cfs.4 uc008cfs.5 Monomer. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K1T4-1; Sequence=Displayed; Name=2; IsoId=Q8K1T4-2; Sequence=VSP_031256; N-glycosylated. extracellular region macromolecular complex external side of plasma membrane identical protein binding protein homooligomerization uc008cfs.1 uc008cfs.2 uc008cfs.3 uc008cfs.4 uc008cfs.5 
ENSMUST00000062672.7 Rpp38 ENSMUST00000062672.7 ribonuclease P/MRP 38 subunit (from RefSeq NM_001013376.2) A2AJG0 A2AJG0_MOUSE ENSMUST00000062672.1 ENSMUST00000062672.2 ENSMUST00000062672.3 ENSMUST00000062672.4 ENSMUST00000062672.5 ENSMUST00000062672.6 NM_001013376 Rpp38 uc008ids.1 uc008ids.2 uc008ids.3 uc008ids.4 fibrillar center tRNA 5'-leader removal ribonuclease P activity nucleolus multimeric ribonuclease P complex ribonuclease P RNA binding RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc008ids.1 uc008ids.2 uc008ids.3 uc008ids.4 
ENSMUST00000062677.12 Tmem11 ENSMUST00000062677.12 transmembrane protein 11, transcript variant 1 (from RefSeq NM_173453.3) ENSMUST00000062677.1 ENSMUST00000062677.10 ENSMUST00000062677.11 ENSMUST00000062677.2 ENSMUST00000062677.3 ENSMUST00000062677.4 ENSMUST00000062677.5 ENSMUST00000062677.6 ENSMUST00000062677.7 ENSMUST00000062677.8 ENSMUST00000062677.9 NM_173453 Q5NCT6 Q8BK08 TMM11_MOUSE uc007jgs.1 uc007jgs.2 uc007jgs.3 uc007jgs.4 Plays a role in mitochondrial morphogenesis. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60. Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the TMEM11 family. Sequence=CAI35260.1; Type=Erroneous gene model prediction; Evidence=; molecular_function mitochondrion mitochondrial inner membrane mitochondrion organization inner mitochondrial membrane organization membrane integral component of membrane integral component of mitochondrial inner membrane uc007jgs.1 uc007jgs.2 uc007jgs.3 uc007jgs.4 
ENSMUST00000062678.11 Rrp1 ENSMUST00000062678.11 ribosomal RNA processing 1 (from RefSeq NM_010925.2) ENSMUST00000062678.1 ENSMUST00000062678.10 ENSMUST00000062678.2 ENSMUST00000062678.3 ENSMUST00000062678.4 ENSMUST00000062678.5 ENSMUST00000062678.6 ENSMUST00000062678.7 ENSMUST00000062678.8 ENSMUST00000062678.9 NM_010925 Nnp1 O35712 P56183 Q9ERE1 Q9JI07 Q9JK67 Q9JKU2 RRP1_MOUSE uc007fxs.1 uc007fxs.2 uc007fxs.3 Plays a critical role in the generation of 28S rRNA. Interacts with C1QBP. Interacts with RRP1B. Nucleus, nucleolus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P56183-1; Sequence=Displayed; Name=2; IsoId=P56183-2; Sequence=VSP_004335, VSP_004336; Name=3; IsoId=P56183-3; Sequence=VSP_004337; Embryonic, expression starting between days 1 and 10. Belongs to the RRP1 family. nucleus nucleolus rRNA processing preribosome, large subunit precursor preribosome, small subunit precursor uc007fxs.1 uc007fxs.2 uc007fxs.3 
ENSMUST00000062683.3 Krtap9-3 ENSMUST00000062683.3 keratin associated protein 9-3 (from RefSeq NM_029351.2) ENSMUST00000062683.1 ENSMUST00000062683.2 KRA93_MOUSE Krtap9-3 NM_029351 Q3V2C1 Q9D718 uc007ljf.1 uc007ljf.2 uc007ljf.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). Interacts with hair keratins. Belongs to the KRTAP type 9 family. molecular_function cellular_component intermediate filament biological_process keratin filament uc007ljf.1 uc007ljf.2 uc007ljf.3 
ENSMUST00000062684.9 Tmem64 ENSMUST00000062684.9 transmembrane protein 64 (from RefSeq NM_181401.3) ENSMUST00000062684.1 ENSMUST00000062684.2 ENSMUST00000062684.3 ENSMUST00000062684.4 ENSMUST00000062684.5 ENSMUST00000062684.6 ENSMUST00000062684.7 ENSMUST00000062684.8 NM_181401 Q3TCK1 Q3TE31 Q3U145 Q6YI45 Q8CBJ4 Q8K2Q6 TMM64_MOUSE uc008sbk.1 uc008sbk.2 uc008sbk.3 uc008sbk.4 Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (PubMed:23395171). Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1 (PubMed:25979161). Interacts with ATP2A2 (PubMed:23395171). Membrane ; Multi-pass membrane protein Endoplasmic reticulum Liver, testis, kidney and muscle. The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain. Mice exhibit increased bone mass due in part to impaired osteoclast formation. Bones show reduced osteoclast numbers (PubMed:23395171). Increased osteogenesis and impaired adipogenesis observed in bone marrow-derived stromal cells (PubMed:25979161). Belongs to the TVP38/TMEM64 family. Sequence=AAN05738.1; Type=Frameshift; Evidence=; protein binding endoplasmic reticulum membrane integral component of membrane regulation of ATPase activity positive regulation of fat cell differentiation negative regulation of osteoblast differentiation positive regulation of osteoclast differentiation positive regulation of bone resorption regulation of cytosolic calcium ion concentration negative regulation of canonical Wnt signaling pathway uc008sbk.1 uc008sbk.2 uc008sbk.3 uc008sbk.4 
ENSMUST00000062694.16 Mapk14 ENSMUST00000062694.16 mitogen-activated protein kinase 14, transcript variant 6 (from RefSeq NR_189138.1) B2KF37 B2KF38 Crk1 Csbp1 Csbp2 ENSMUST00000062694.1 ENSMUST00000062694.10 ENSMUST00000062694.11 ENSMUST00000062694.12 ENSMUST00000062694.13 ENSMUST00000062694.14 ENSMUST00000062694.15 ENSMUST00000062694.2 ENSMUST00000062694.3 ENSMUST00000062694.4 ENSMUST00000062694.5 ENSMUST00000062694.6 ENSMUST00000062694.7 ENSMUST00000062694.8 ENSMUST00000062694.9 MK14_MOUSE Mapk14 NR_189138 O08666 P47811 Q3U6R5 Q3UZS3 Q8C289 Q9JLV8 Q9QZ80 uc008brl.1 uc008brl.2 uc008brl.3 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF- kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc- N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Phosphorylates S100A9 at 'Thr-113' (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Activated by cell stresses such as DNA damage, heat shock, osmotic shock, anisomycin and sodium arsenite, as well as pro-inflammatory stimuli such as bacterial lipopolysaccharide (LPS) and interleukin-1. Activation occurs through dual phosphorylation of Thr- 180 and Tyr-182 by either of two dual specificity kinases, MAP2K3/MKK3 or MAP2K6/MKK6, and potentially also MAP2K4/MKK4, as well as by TAB1- mediated autophosphorylation. MAPK14 phosphorylated on both Thr-180 and Tyr-182 is 10-20-fold more active than MAPK14 phosphorylated only on Thr-180, whereas MAPK14 phosphorylated on Tyr-182 alone is inactive. whereas Thr-180 is necessary for catalysis, Tyr-182 may be required for auto-activation and substrate recognition. Phosphorylated at Tyr-323 by ZAP70 in an alternative activation pathway in response to TCR signaling in T-cells. This alternative pathway is inhibited by GADD45A. Inhibited by dual specificity phosphatases, such as DUSP1, DUSP10, and DUSP16. Specifically inhibited by the binding of pyridinyl-imidazole compounds, which are cytokine-suppressive anti-inflammatory drugs (CSAID). SB203580 is an inhibitor of MAPK14. Kinetic parameters: KM=212 uM for ATP (when both Thr-180 and Tyr-182 are phosphorylated) ; KM=1669 uM for ATP (when only Thr-180 is phosphorylated) ; KM=656 uM for EGFR peptide as a substrate (when both Thr-180 and Tyr- 182 are phosphorylated) ; KM=2800 uM for EGFR peptide as a substrate (when only Thr-180 is phosphorylated) ; KM=2.03 uM for ATF2 as a substrate (when both Thr-180 and Tyr-182 are phosphorylated) ; KM=20.1 uM for ATF2 as a substrate (when only Thr-180 is phosphorylated) ; Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (By similarity). Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR (By similarity). This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation (By similarity). Interacts with SPAG9 and GADD45A (By similarity). Interacts with CDC25B, CDC25C, DUSP1, DUSP10, DUSP16, NP60, SUPT20H and TAB1. Interacts with casein kinase II subunits CSNK2A1 and CSNK2B. Interacts with PPM1D. Interacts with CDK5RAP3; recruits PPM1D to MAPK14 and may regulate its dephosphorylation (By similarity). Interacts with DUSP2; this interaction does not lead to catalytic activation of DUSP2 and dephosphrylation of MAPK14 (PubMed:16288922). P47811; Q61233: Lcp1; NbExp=5; IntAct=EBI-298727, EBI-309345; P47811; Q9WUI1: Mapk11; NbExp=10; IntAct=EBI-298727, EBI-645081; P47811; P49138: Mapkapk2; NbExp=2; IntAct=EBI-298727, EBI-298776; P47811; Q9WVS6: Prkn; NbExp=3; IntAct=EBI-298727, EBI-973635; P47811; P55012: Slc12a2; NbExp=2; IntAct=EBI-298727, EBI-621078; P47811; Q9Z1W9: Stk39; NbExp=2; IntAct=EBI-298727, EBI-444764; P47811; Q99956: DUSP9; Xeno; NbExp=2; IntAct=EBI-298727, EBI-3906678; P47811; P49137-1: MAPKAPK2; Xeno; NbExp=2; IntAct=EBI-298727, EBI-15629963; P47811; P35236: PTPN7; Xeno; NbExp=2; IntAct=EBI-298727, EBI-2265723; Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P47811-1; Sequence=Displayed; Name=2; Synonyms=Piccolo; IsoId=P47811-2; Sequence=VSP_004846, VSP_007545; Name=3; IsoId=P47811-3; Sequence=VSP_007544; Name=4; IsoId=P47811-4; Sequence=VSP_022359; Macrophages, monocytes, T- and B-lymphocytes. Isoform 2 is specifically expressed in kidney and liver. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. Dually phosphorylated on Thr-180 and Tyr-182 by the MAP2Ks MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6 in response to inflammatory cytokines, environmental stress or growth factors, which activates the enzyme. Dual phosphorylation can also be mediated by TAB1-mediated autophosphorylation. TCR engagement in T-cells also leads to Tyr-323 phosphorylation by ZAP70. Dephosphorylated and inactivated by DUPS1, DUSP10 and DUSP16. PPM1D also mediates dephosphorylation and inactivation of MAPK14 (By similarity). Acetylated at Lys-53 and Lys-152 by KAT2B and EP300. Acetylation at Lys-53 increases the affinity for ATP and enhances kinase activity. Lys-53 and Lys-152 are deacetylated by HDAC3 (By similarity). Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. DNA damage checkpoint nucleotide binding cell morphogenesis spindle pole cartilage condensation angiogenesis placenta development chondrocyte differentiation positive regulation of cytokine secretion involved in immune response protein kinase activity protein serine/threonine kinase activity MAP kinase activity protein binding ATP binding cell nucleus nucleoplasm cytoplasm mitochondrion cytosol glucose metabolic process regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein phosphorylation apoptotic process cellular response to DNA damage stimulus transmembrane receptor protein serine/threonine kinase signaling pathway skeletal muscle tissue development protein C-terminus binding regulation of gene expression positive regulation of gene expression positive regulation of macrophage chemotaxis positive regulation of myotube differentiation myoblast differentiation involved in skeletal muscle regeneration kinase activity phosphorylation nuclear speck transferase activity peptidyl-serine phosphorylation fatty acid oxidation enzyme binding protein phosphatase binding regulation of ossification osteoclast differentiation positive regulation of cyclase activity lipopolysaccharide-mediated signaling pathway response to muramyl dipeptide response to lipopolysaccharide intracellular signal transduction cellular response to vascular endothelial growth factor stimulus response to muscle stretch p38MAPK cascade positive regulation of protein import into nucleus signal transduction in response to DNA damage positive regulation of erythrocyte differentiation positive regulation of myoblast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import protein autophosphorylation vascular endothelial growth factor receptor signaling pathway mitogen-activated protein kinase p38 binding striated muscle cell differentiation stress-activated MAPK cascade NFAT protein binding positive regulation of cardiac muscle cell proliferation cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to tumor necrosis factor cellular response to ionizing radiation negative regulation of canonical Wnt signaling pathway positive regulation of brown fat cell differentiation stress-induced premature senescence cellular response to virus glutamatergic synapse regulation of cytokine production involved in inflammatory response positive regulation of myoblast fusion positive regulation of metallopeptidase activity positive regulation of reactive oxygen species metabolic process positive regulation of interleukin-12 secretion uc008brl.1 uc008brl.2 uc008brl.3 
ENSMUST00000062695.2 Ube2dnl2 ENSMUST00000062695.2 ubiquitin-conjugating enzyme E2D N-terminal like 2 (from RefSeq NM_001081661.1) 4930524E20Rik A2AFH2 A2AFH2_MOUSE ENSMUST00000062695.1 NM_001081661 Ube2dnl2 uc009udz.1 uc009udz.2 Belongs to the ubiquitin-conjugating enzyme family. ubiquitin ligase complex nucleotide binding ATP binding ubiquitin-dependent protein catabolic process transferase activity ubiquitin protein ligase binding ubiquitin conjugating enzyme activity protein K48-linked ubiquitination uc009udz.1 uc009udz.2 
ENSMUST00000062709.4 Hoxb13 ENSMUST00000062709.4 homeobox B13 (from RefSeq NM_008267.4) ENSMUST00000062709.1 ENSMUST00000062709.2 ENSMUST00000062709.3 HXB13_MOUSE NM_008267 P70321 Q80Y12 uc007lbk.1 uc007lbk.2 uc007lbk.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (By similarity). Heterodimer with MEIS1 and MEIS2. Nucleus. Exhibits both spatial and temporal colinearity within the main body axis. At 12.5 dpc, is detected in hindgut, urogenital tract, spinal cord and tailbud. Not detected in secondary axes such as the limb and the genital tubercule. Belongs to the Abd-B homeobox family. negative regulation of transcription from RNA polymerase II promoter angiogenesis morphogenesis of an epithelium DNA binding protein binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated multicellular organism development methyl-CpG binding prostate gland development response to testosterone regulation of growth sequence-specific DNA binding prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis epithelial cell maturation involved in prostate gland development uc007lbk.1 uc007lbk.2 uc007lbk.3 
ENSMUST00000062721.11 Lipi ENSMUST00000062721.11 lipase, member I (from RefSeq NM_001252513.2) ENSMUST00000062721.1 ENSMUST00000062721.10 ENSMUST00000062721.2 ENSMUST00000062721.3 ENSMUST00000062721.4 ENSMUST00000062721.5 ENSMUST00000062721.6 ENSMUST00000062721.7 ENSMUST00000062721.8 ENSMUST00000062721.9 F6YQT7 F6YQT7_MOUSE Lipi NM_001252513 uc007zrn.1 uc007zrn.2 uc007zrn.3 uc007zrn.4 uc007zrn.5 Secreted Belongs to the AB hydrolase superfamily. Lipase family. phospholipase activity extracellular region extracellular space plasma membrane lipid metabolic process heparin binding lipid catabolic process lipase activity metal ion binding carboxylic ester hydrolase activity uc007zrn.1 uc007zrn.2 uc007zrn.3 uc007zrn.4 uc007zrn.5 
ENSMUST00000062723.14 Acp3 ENSMUST00000062723.14 acid phosphatase 3, transcript variant 1 (from RefSeq NM_207668.2) A4QPG2 Acpp B8JJZ5 B8JJZ6 ENSMUST00000062723.1 ENSMUST00000062723.10 ENSMUST00000062723.11 ENSMUST00000062723.12 ENSMUST00000062723.13 ENSMUST00000062723.2 ENSMUST00000062723.3 ENSMUST00000062723.4 ENSMUST00000062723.5 ENSMUST00000062723.6 ENSMUST00000062723.7 ENSMUST00000062723.8 ENSMUST00000062723.9 NM_207668 PPAP_MOUSE Q8C682 Q8CE08 Q9QXH7 uc009rhl.1 uc009rhl.2 uc009rhl.3 A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity). [Isoform 2]: In addition to its tyrosine phosphatase activity, also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP. This extracellular adenosine leads to a decrease in chronic pain by activating A1R in nociceptive neurons. Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2; Evidence=; Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377, ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z- octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:39835, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:74544, ChEBI:CHEBI:75757; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39836; Evidence=; Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Homodimer; dimer formation is required for phosphatase activity. [Isoform 1]: Secreted [Isoform 2]: Cell membrane ; Single-pass type I membrane protein Lysosome membrane ; Single- pass type I membrane protein Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CE08-1; Sequence=Displayed; Name=2; Synonyms=TMPase, TM-PAP, cellular PAP, cPAP; IsoId=Q8CE08-2; Sequence=VSP_036024; [Isoform 1]: Expressed in salivary gland, thymus and thyroid gland. [Isoform 2]: Widely expressed in prostate lobes, brain, kidney, liver, lung, muscle, placenta, salivary gland, spleen, thyroid and thymus. Locates to Schwann cells and fibroblasts. Expressed in peptidergic and non-peptidergic nociceptive (pain-sensing) neurons. Preferentially expressed in non-peptidergic doral root ganglia neurons. Null mice display greater thermal hyperalgesia (pain sensitivity) and mechanical allodynia. No thiamine monophosphatase (TMPase) activity detected in dorsal root ganglion (DRG) neurons. Belongs to the histidine acid phosphatase family. acid phosphatase activity extracellular region extracellular space lysosome lysosomal membrane multivesicular body plasma membrane purine nucleobase metabolic process thiamine metabolic process 5'-nucleotidase activity nucleotide metabolic process vesicle membrane membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity secretory granule filopodium Golgi cisterna choline binding thiamine phosphate phosphatase activity identical protein binding protein homodimerization activity apical part of cell adenosine metabolic process protein homotetramerization regulation of sensory perception of pain lysophosphatidic acid phosphatase activity positive regulation of adenosine receptor signaling pathway uc009rhl.1 uc009rhl.2 uc009rhl.3 
ENSMUST00000062740.15 Acp1 ENSMUST00000062740.15 acid phosphatase 1, soluble, transcript variant 2 (from RefSeq NM_021330.4) Acp1 ENSMUST00000062740.1 ENSMUST00000062740.10 ENSMUST00000062740.11 ENSMUST00000062740.12 ENSMUST00000062740.13 ENSMUST00000062740.14 ENSMUST00000062740.2 ENSMUST00000062740.3 ENSMUST00000062740.4 ENSMUST00000062740.5 ENSMUST00000062740.6 ENSMUST00000062740.7 ENSMUST00000062740.8 ENSMUST00000062740.9 NM_021330 O88739 O88740 PPAC_MOUSE Q9D358 Q9QWF5 uc007ngw.1 uc007ngw.2 uc007ngw.3 uc007ngw.4 Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10685; Evidence=; Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15018; Evidence=; Inhibited by sulfhydryl reagents. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1. [Isoform 1]: Interacts with the SH3 domain of SPTAN1. There is no interaction observed for isoform 2. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1 ; Synonyms=m-IF1 ; IsoId=Q9D358-1; Sequence=Displayed; Name=2 ; Synonyms=m-IF2 ; IsoId=Q9D358-2; Sequence=VSP_050726; Widely expressed with highest levels in brain and liver and lowest levels in muscle. [Isoform 2]: Phosphorylated by LCK. Phosphorylation at Tyr-132 increases its phosphatase activity. Belongs to the low molecular weight phosphotyrosine protein phosphatase family. acid phosphatase activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity cytoplasm cytosol protein dephosphorylation cytoplasmic side of plasma membrane hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation sarcolemma uc007ngw.1 uc007ngw.2 uc007ngw.3 uc007ngw.4 
ENSMUST00000062747.6 Klf17 ENSMUST00000062747.6 Kruppel-like transcription factor 17 (from RefSeq NM_029416.2) B1ASI5 ENSMUST00000062747.1 ENSMUST00000062747.2 ENSMUST00000062747.3 ENSMUST00000062747.4 ENSMUST00000062747.5 Gzf KLF17_MOUSE NM_029416 Q3UT30 Q6P233 Q8CFA7 Q9D351 Zfp393 Znf393 uc008uix.1 uc008uix.2 uc008uix.3 Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development. Nucleus Exclusively expressed in testis and ovary. Localized to step 3-8 spermatids in testis and growing oocytes in ovary. Belongs to the Sp1 C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription from RNA polymerase II promoter gamete generation transcription regulatory region DNA binding metal ion binding uc008uix.1 uc008uix.2 uc008uix.3 
ENSMUST00000062750.12 Cfap100 ENSMUST00000062750.12 Cfap100 (from geneSymbol) A0A171EBL0 A0A171EBL0_MOUSE BC047211 Cfap100 ENSMUST00000062750.1 ENSMUST00000062750.10 ENSMUST00000062750.11 ENSMUST00000062750.2 ENSMUST00000062750.3 ENSMUST00000062750.4 ENSMUST00000062750.5 ENSMUST00000062750.6 ENSMUST00000062750.7 ENSMUST00000062750.8 ENSMUST00000062750.9 uc009cxg.1 uc009cxg.2 uc009cxg.3 uc009cxg.4 uc009cxg.1 uc009cxg.2 uc009cxg.3 uc009cxg.4 
ENSMUST00000062753.3 D030056L22Rik ENSMUST00000062753.3 RIKEN cDNA D030056L22 gene, transcript variant 1 (from RefSeq NM_001374130.1) CI040_MOUSE ENSMUST00000062753.1 ENSMUST00000062753.2 NM_001374130 Q8BJJ5 Q8VCE4 uc008gxz.1 uc008gxz.2 uc008gxz.3 molecular_function cellular_component biological_process uc008gxz.1 uc008gxz.2 uc008gxz.3 
ENSMUST00000062755.10 Borcs5 ENSMUST00000062755.10 BLOC-1 related complex subunit 5, transcript variant 2 (from RefSeq NM_026371.3) BORC5_MOUSE Borcs5 ENSMUST00000062755.1 ENSMUST00000062755.2 ENSMUST00000062755.3 ENSMUST00000062755.4 ENSMUST00000062755.5 ENSMUST00000062755.6 ENSMUST00000062755.7 ENSMUST00000062755.8 ENSMUST00000062755.9 NM_026371 Q8BJB0 Q9D920 uc012eul.1 uc012eul.2 uc012eul.3 As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility. Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. Interacts with ARL8B, KIF5A, KLC1 and PLEKHM2; links the lysosomal BORC complex to the microtubule plus-end-directed kinesin motor. Lysosome membrane ; Lipid-anchor ; Cytoplasmic side Myristoylation at Gly-2 mediates attachment to lysosome membranes. Belongs to the BORCS5 family. molecular_function lysosome lysosomal membrane membrane synaptic vesicle membrane intrinsic component of membrane lysosome localization organelle transport along microtubule cytoplasmic side of lysosomal membrane BORC complex positive regulation of anterograde synaptic vesicle transport plus-end kinesin complex uc012eul.1 uc012eul.2 uc012eul.3 
ENSMUST00000062758.11 Cpa5 ENSMUST00000062758.11 carboxypeptidase A5 (from RefSeq NM_144537.4) CBPA5_MOUSE ENSMUST00000062758.1 ENSMUST00000062758.10 ENSMUST00000062758.2 ENSMUST00000062758.3 ENSMUST00000062758.4 ENSMUST00000062758.5 ENSMUST00000062758.6 ENSMUST00000062758.7 ENSMUST00000062758.8 ENSMUST00000062758.9 NM_144537 Q8R4H4 uc009bfp.1 uc009bfp.2 uc009bfp.3 This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is expressed in mouse testes where the encoded protein is localized to the germ cells. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF466283.1, AK015256.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted Detected in testis germ cells. Belongs to the peptidase M14 family. carboxypeptidase activity metallocarboxypeptidase activity extracellular region extracellular space proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding uc009bfp.1 uc009bfp.2 uc009bfp.3 
ENSMUST00000062759.4 Ccr10 ENSMUST00000062759.4 C-C motif chemokine receptor 10 (from RefSeq NM_007721.4) CCR10_MOUSE Cmkbr9 ENSMUST00000062759.1 ENSMUST00000062759.2 ENSMUST00000062759.3 Gpr2 NM_007721 Q542A4 Q9JIP1 Q9JL20 Q9JL21 uc007lns.1 uc007lns.2 uc007lns.3 Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level. Cell membrane; Multi-pass membrane protein. Expressed at high levels in small intestine, colon, lymph nodes, Peyer patches and at lower levels in thymus, lung and spleen. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity chemokine receptor activity endoplasmic reticulum plasma membrane integral component of plasma membrane chemotaxis immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration external side of plasma membrane cell surface membrane integral component of membrane C-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding cell chemotaxis chemokine-mediated signaling pathway uc007lns.1 uc007lns.2 uc007lns.3 
ENSMUST00000062765.14 Zfp583 ENSMUST00000062765.14 May be involved in transcriptional regulation. (from UniProt Q3V080) BC056221 ENSMUST00000062765.1 ENSMUST00000062765.10 ENSMUST00000062765.11 ENSMUST00000062765.12 ENSMUST00000062765.13 ENSMUST00000062765.2 ENSMUST00000062765.3 ENSMUST00000062765.4 ENSMUST00000062765.5 ENSMUST00000062765.6 ENSMUST00000062765.7 ENSMUST00000062765.8 ENSMUST00000062765.9 Q3V080 Q3V3L4 ZN583_MOUSE Znf583 uc009fbd.1 uc009fbd.2 uc009fbd.3 uc009fbd.4 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009fbd.1 uc009fbd.2 uc009fbd.3 uc009fbd.4 
ENSMUST00000062769.7 Cetn1 ENSMUST00000062769.7 Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (PubMed:27530713). (from UniProt P41209) AK076986 CETN1_MOUSE Calt Cetn1 ENSMUST00000062769.1 ENSMUST00000062769.2 ENSMUST00000062769.3 ENSMUST00000062769.4 ENSMUST00000062769.5 ENSMUST00000062769.6 P41209 Q3V119 Q9D9G9 Q9DAL6 uc008eaj.1 uc008eaj.2 uc008eaj.3 Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (PubMed:27530713). Monomer (By similarity). Interacts with CIMAP3 (PubMed:20643351). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium Note=Centrosome of interphase and mitotic cells. In the retinal photoreceptor cells, localizes at the connecting cilium, a thin bridge linking the cell body and the light- sensing outer segment (PubMed:30120214). Expressed in testis. Localizes to the caudal portion of spermatozoa in seminiferous tubule and epididymis (PubMed:10486202). Expressed in retina photoreceptor cells (at protein level) (PubMed:30120214). First expressed at 14 days postpartum (dpp). Levels increase dramatically between 14 dpp and 17 dpp. Binds two moles of calcium per mole of protein. Belongs to the centrin family. mitotic cell cycle spindle pole calcium ion binding cytoplasm centrosome centriole microtubule organizing center cytoskeleton nucleotide-excision repair cell cycle centriole replication microtubule binding G-protein beta/gamma-subunit complex binding photoreceptor connecting cilium heterotrimeric G-protein binding cellular response to heat metal ion binding cell division uc008eaj.1 uc008eaj.2 uc008eaj.3 
ENSMUST00000062784.8 Calhm6 ENSMUST00000062784.8 calcium homeostasis modulator family member 6 (from RefSeq NM_175449.4) CAHM6_MOUSE ENSMUST00000062784.1 ENSMUST00000062784.2 ENSMUST00000062784.3 ENSMUST00000062784.4 ENSMUST00000062784.5 ENSMUST00000062784.6 ENSMUST00000062784.7 Fam26f NM_175449 Q8C9E8 uc007eur.1 uc007eur.2 uc007eur.3 uc007eur.4 Pore-forming subunit of a voltage-gated ion channel. Membrane ; Multi-pass membrane protein Belongs to the CALHM family. integral component of plasma membrane ion transport membrane integral component of membrane uc007eur.1 uc007eur.2 uc007eur.3 uc007eur.4 
ENSMUST00000062787.9 Cd300e ENSMUST00000062787.9 CD300E molecule (from RefSeq NM_172050.3) CLM2_MOUSE Cd300le Clm2 ENSMUST00000062787.1 ENSMUST00000062787.2 ENSMUST00000062787.3 ENSMUST00000062787.4 ENSMUST00000062787.5 ENSMUST00000062787.6 ENSMUST00000062787.7 ENSMUST00000062787.8 NM_172050 Q8K249 uc007mgk.1 uc007mgk.2 uc007mgk.3 uc007mgk.4 Probably acts as an activating receptor. Interacts with TYROBP. Cell membrane ; Single-pass type I membrane protein Belongs to the CD300 family. immune system process molecular_function plasma membrane biological_process membrane integral component of membrane uc007mgk.1 uc007mgk.2 uc007mgk.3 uc007mgk.4 
ENSMUST00000062789.15 Lacc1 ENSMUST00000062789.15 laccase domain containing 1 (from RefSeq NM_172488.2) ENSMUST00000062789.1 ENSMUST00000062789.10 ENSMUST00000062789.11 ENSMUST00000062789.12 ENSMUST00000062789.13 ENSMUST00000062789.14 ENSMUST00000062789.2 ENSMUST00000062789.3 ENSMUST00000062789.4 ENSMUST00000062789.5 ENSMUST00000062789.6 ENSMUST00000062789.7 ENSMUST00000062789.8 ENSMUST00000062789.9 Famin LACC1_MOUSE Lacc1 NM_172488 Q14AQ3 Q3U600 Q8BZT9 uc007urq.1 uc007urq.2 uc007urq.3 Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1- phosphate and the respective free bases, adenine, guanine and hypoxanthine (By similarity). Also catalyzes the phosphorolysis of S- methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (By similarity). Also has adenosine deaminase activity (By similarity). Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages (PubMed:27478939, PubMed:31978345). Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic- mitochondrial redox interface (PubMed:31978345). The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity (PubMed:31978345). Participates in pattern recognition receptor-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (By similarity). Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (By similarity). Does not show laccase activity (By similarity). Reaction=adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate; Xref=Rhea:RHEA:27642, ChEBI:CHEBI:16335, ChEBI:CHEBI:16708, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27643; Evidence=; Reaction=inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine; Xref=Rhea:RHEA:27646, ChEBI:CHEBI:17368, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27647; Evidence=; Reaction=guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine; Xref=Rhea:RHEA:13233, ChEBI:CHEBI:16235, ChEBI:CHEBI:16750, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13234; Evidence=; Reaction=phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5- thio-alpha-D-ribose 1-phosphate; Xref=Rhea:RHEA:11852, ChEBI:CHEBI:16708, ChEBI:CHEBI:17509, ChEBI:CHEBI:43474, ChEBI:CHEBI:58533; EC=2.4.2.28; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11853; Evidence=; Reaction=adenosine + H(+) + H2O = inosine + NH4(+); Xref=Rhea:RHEA:24408, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16335, ChEBI:CHEBI:17596, ChEBI:CHEBI:28938; EC=3.5.4.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24409; Evidence=; Interacts with FASN. Interacts with SDHA. Interacts with ATF6, EIF2AK3 and ERN1. Cytoplasm Nucleus Endoplasmic reticulum Peroxisome Note=Upon stimulation of the pattern- recognition receptor (PRR) NOD2, localizes to the endoplasmic reticulum. Predominantly expressed in myeloid cells (PubMed:30510070). Highly expressed in primary macrophages and dendritic cells sorted from the peritoneum or spleen, respectively (at protein level) (PubMed:30510070). Phosphorylated on tyrosine residues. No visible phenotype in normal conditions (PubMed:30510070). Mice show increased inflammatory response in mouse models of arthritis and inflammation (PubMed:30510070). Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. copper ion binding peroxisome biological_process uc007urq.1 uc007urq.2 uc007urq.3 
ENSMUST00000062802.5 Lyrm2 ENSMUST00000062802.5 LYR motif containing 2 (from RefSeq NM_175364.4) A2ANY7 ENSMUST00000062802.1 ENSMUST00000062802.2 ENSMUST00000062802.3 ENSMUST00000062802.4 LYRM2_MOUSE NM_175364 Q8R033 uc008sfe.1 uc008sfe.2 uc008sfe.3 uc008sfe.4 uc008sfe.5 Involved in effecient integration of the N-module into mitochondrial respiratory chain complex I. Mitochondrion Belongs to the complex I LYR family. molecular_function mitochondrion biological_process uc008sfe.1 uc008sfe.2 uc008sfe.3 uc008sfe.4 uc008sfe.5 
ENSMUST00000062806.6 Lect2 ENSMUST00000062806.6 leukocyte cell-derived chemotaxin 2 (from RefSeq NM_010702.2) A0A0R4J0R8 A0A0R4J0R8_MOUSE ENSMUST00000062806.1 ENSMUST00000062806.2 ENSMUST00000062806.3 ENSMUST00000062806.4 ENSMUST00000062806.5 Lect2 NM_010702 uc007qst.1 uc007qst.2 uc007qst.3 uc007qst.4 Belongs to the LECT2/MIM-1 family. identical protein binding metal ion binding uc007qst.1 uc007qst.2 uc007qst.3 uc007qst.4 
ENSMUST00000062821.13 Emid1 ENSMUST00000062821.13 EMI domain containing 1, transcript variant 1 (from RefSeq NM_080595.3) EMID1_MOUSE ENSMUST00000062821.1 ENSMUST00000062821.10 ENSMUST00000062821.11 ENSMUST00000062821.12 ENSMUST00000062821.2 ENSMUST00000062821.3 ENSMUST00000062821.4 ENSMUST00000062821.5 ENSMUST00000062821.6 ENSMUST00000062821.7 ENSMUST00000062821.8 ENSMUST00000062821.9 Emu1 NM_080595 Q91VF5 uc007hwg.1 uc007hwg.2 uc007hwg.3 Homo- or heteromers. Secreted, extracellular space, extracellular matrix. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VF5-1; Sequence=Displayed; Name=2; IsoId=Q91VF5-2; Sequence=VSP_008446; At 9.5 dpc it is expressed in the nephric duct, the dorsal neural tube, the epithelia of the branchial arches, and the optic vesicle. In 14.5 dpc embryos, like in earlier ones, it is expressed in the dorsal spinal cord and the brain, where it is restricted to the proliferating ependymal and cortical cell layers. Expression is also detected in smooth muscles of the digestive tract as well as in the epithelia of the salivary gland, the inner ear, and the developing nephrons of kidney. In early embryos, it is expressed in the epithelium of the branchial arches. At 14.5 dpc, Emu1 is restricted to the epithelium in the advanced developing kidney (at 15.5 dpc and later), transcripts are detected in the epithelium of the developing nephrons and in the collecting duct epithelium. [Isoform 2]: May be due to a competing acceptor splice site. extracellular matrix structural constituent protein binding extracellular region collagen trimer endoplasmic reticulum Golgi apparatus extracellular matrix uc007hwg.1 uc007hwg.2 uc007hwg.3 
ENSMUST00000062824.12 Tmem53 ENSMUST00000062824.12 transmembrane protein 53, transcript variant 2 (from RefSeq NM_026837.3) A2AE66 ENSMUST00000062824.1 ENSMUST00000062824.10 ENSMUST00000062824.11 ENSMUST00000062824.2 ENSMUST00000062824.3 ENSMUST00000062824.4 ENSMUST00000062824.5 ENSMUST00000062824.6 ENSMUST00000062824.7 ENSMUST00000062824.8 ENSMUST00000062824.9 NM_026837 Net4 Q8VDW5 Q9D0Z3 Q9DAF0 TMM53_MOUSE uc008uii.1 uc008uii.2 uc008uii.3 uc008uii.4 Negatively regulates bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD1/5/9 proteins. Nucleus outer membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D0Z3-1; Sequence=Displayed; Name=2; IsoId=Q9D0Z3-2; Sequence=VSP_024449; Name=3; IsoId=Q9D0Z3-3; Sequence=VSP_024447, VSP_024448; Expressed in liver (at protein level). Expressed in calvaria at 16.5 dpc. Knockout mice do not display severe skeletal abnormity at birth, but exhibit late-onset short stature. They show craniofacial dysmorphias, including hypertelorism, thickening of the calvaria and minor sclerosis of the skull base. Platyspondyly is also observed, as well as short limbs and underconstriction of the diaphyses. Belongs to the TMEM53 family. molecular_function biological_process membrane integral component of membrane uc008uii.1 uc008uii.2 uc008uii.3 uc008uii.4 
ENSMUST00000062829.9 Hoxa6 ENSMUST00000062829.9 homeobox A6 (from RefSeq NM_010454.3) ENSMUST00000062829.1 ENSMUST00000062829.2 ENSMUST00000062829.3 ENSMUST00000062829.4 ENSMUST00000062829.5 ENSMUST00000062829.6 ENSMUST00000062829.7 ENSMUST00000062829.8 Hoxa6 NM_010454 Q0VEU7 Q0VEU7_MOUSE uc009byi.1 uc009byi.2 uc009byi.3 Nucleus Belongs to the Antp homeobox family. DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development sequence-specific DNA binding uc009byi.1 uc009byi.2 uc009byi.3 
ENSMUST00000062831.16 Ercc2 ENSMUST00000062831.16 excision repair cross-complementing rodent repair deficiency, complementation group 2, transcript variant 1 (from RefSeq NM_007949.5) ENSMUST00000062831.1 ENSMUST00000062831.10 ENSMUST00000062831.11 ENSMUST00000062831.12 ENSMUST00000062831.13 ENSMUST00000062831.14 ENSMUST00000062831.15 ENSMUST00000062831.2 ENSMUST00000062831.3 ENSMUST00000062831.4 ENSMUST00000062831.5 ENSMUST00000062831.6 ENSMUST00000062831.7 ENSMUST00000062831.8 ENSMUST00000062831.9 ERCC2_MOUSE NM_007949 O08811 Q8C487 Q9DC01 Xpd uc009flq.1 uc009flq.2 uc009flq.3 ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre- initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK- activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. The interaction with GTF2H2 results in the stimulation of the 5'-->3' helicase activity. Component of the MMXD complex, which includes CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5. Interacts with CIAO1 and CIAO2B; the interaction WITH CIAO2B is direct. Interacts with ATF7IP. Interacts directly with MMS19. Nucleus. Cytoplasm, cytoskeleton, spindle ISGylated. Belongs to the helicase family. RAD3/XPD subfamily. Sequence=BAB23443.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; regulation of mitotic recombination nucleotide binding core TFIIH complex maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleotide-excision repair, DNA duplex unwinding response to hypoxia in utero embryonic development nucleic acid binding DNA binding DNA helicase activity damaged DNA binding helicase activity protein kinase activity ATP binding nucleus nucleoplasm transcription factor TFIID complex holo TFIIH complex cytoplasm spindle cytosol cytoskeleton nucleobase-containing compound metabolic process DNA repair transcription-coupled nucleotide-excision repair nucleotide-excision repair transcription elongation from RNA polymerase I promoter transcription from RNA polymerase II promoter protein phosphorylation apoptotic process cellular response to DNA damage stimulus response to oxidative stress chromosome segregation aging protein C-terminus binding DNA-dependent ATPase activity cell proliferation RNA polymerase II carboxy-terminal domain kinase activity response to UV UV protection post-embryonic development hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides spinal cord development hair cycle process extracellular matrix organization bone mineralization protein binding, bridging central nervous system myelin formation nucleotide-excision repair, DNA incision multicellular organism growth hair cell differentiation embryonic cleavage ribosomal small subunit biogenesis 5'-3' DNA helicase activity erythrocyte maturation positive regulation of DNA binding skin development positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of mitotic recombination metal ion binding protein N-terminus binding embryonic organ development hair follicle maturation iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding hematopoietic stem cell differentiation CAK-ERCC2 complex MMXD complex regulation of mitotic cell cycle phase transition uc009flq.1 uc009flq.2 uc009flq.3 
ENSMUST00000062855.15 Mier2 ENSMUST00000062855.15 MIER family member 2, transcript variant 2 (from RefSeq NM_027422.4) ENSMUST00000062855.1 ENSMUST00000062855.10 ENSMUST00000062855.11 ENSMUST00000062855.12 ENSMUST00000062855.13 ENSMUST00000062855.14 ENSMUST00000062855.2 ENSMUST00000062855.3 ENSMUST00000062855.4 ENSMUST00000062855.5 ENSMUST00000062855.6 ENSMUST00000062855.7 ENSMUST00000062855.8 ENSMUST00000062855.9 Kiaa1193 MIER2_MOUSE NM_027422 Q3U3N0 Q5XJI0 Q66JU5 Q69ZP0 Q6NXL7 uc007fyx.1 uc007fyx.2 uc007fyx.3 uc007fyx.4 Transcriptional repressor. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U3N0-1; Sequence=Displayed; Name=2; IsoId=Q3U3N0-2; Sequence=VSP_030097; Name=3; IsoId=Q3U3N0-3; Sequence=VSP_030096, VSP_030097, VSP_030098; Sequence=BAD32406.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding DNA binding transcription corepressor activity histone deacetylase activity nucleus nucleoplasm cytoplasm histone deacetylation macromolecular complex histone deacetylase binding uc007fyx.1 uc007fyx.2 uc007fyx.3 uc007fyx.4 
ENSMUST00000062879.5 Gm5414 ENSMUST00000062879.5 predicted gene 5414 (from RefSeq NM_001003670.2) EG406223 ENSMUST00000062879.1 ENSMUST00000062879.2 ENSMUST00000062879.3 ENSMUST00000062879.4 Gm5414 NM_001003670 Q6IFZ8 Q6IFZ8_MOUSE uc007xts.1 uc007xts.2 Belongs to the intermediate filament family. molecular_function intermediate filament biological_process keratin filament uc007xts.1 uc007xts.2 
ENSMUST00000062883.7 Fam13c ENSMUST00000062883.7 family with sequence similarity 13, member C, transcript variant 1 (from RefSeq NM_024244.5) D3YTZ3 ENSMUST00000062883.1 ENSMUST00000062883.2 ENSMUST00000062883.3 ENSMUST00000062883.4 ENSMUST00000062883.5 ENSMUST00000062883.6 FA13C_MOUSE Fam13c1 NM_024244 Q9DBR2 uc007fnx.1 uc007fnx.2 uc007fnx.3 uc007fnx.4 Belongs to the FAM13 family. molecular_function cellular_component biological_process uc007fnx.1 uc007fnx.2 uc007fnx.3 uc007fnx.4 
ENSMUST00000062893.12 Cenpe ENSMUST00000062893.12 centromere protein E (from RefSeq NM_173762.4) Cenpe E9QKK1 E9QKK1_MOUSE ENSMUST00000062893.1 ENSMUST00000062893.10 ENSMUST00000062893.11 ENSMUST00000062893.2 ENSMUST00000062893.3 ENSMUST00000062893.4 ENSMUST00000062893.5 ENSMUST00000062893.6 ENSMUST00000062893.7 ENSMUST00000062893.8 ENSMUST00000062893.9 NM_173762 uc008rkz.1 uc008rkz.2 uc008rkz.3 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding mitotic cell cycle chromosome, centromeric region kinetochore condensed chromosome, centromeric region motor activity microtubule motor activity ATP binding nucleus nucleoplasm chromosome kinetochore microtubule cytosol microtubule microtubule-based movement mitotic spindle organization chromosome segregation mitotic chromosome movement towards spindle pole mitotic metaphase plate congression microtubule binding microtubule cytoskeleton regulation of mitotic metaphase/anaphase transition midbody kinetochore binding positive regulation of protein kinase activity spindle midzone metaphase plate congression attachment of mitotic spindle microtubules to kinetochore kinetochore assembly microtubule plus-end directed mitotic chromosome migration lateral attachment of mitotic spindle microtubules to kinetochore mitotic spindle midzone uc008rkz.1 uc008rkz.2 uc008rkz.3 
ENSMUST00000062902.8 AB041806 ENSMUST00000062902.8 hypothetical protein, MNCb-2457 (from RefSeq NR_189008.1) ENSMUST00000062902.1 ENSMUST00000062902.2 ENSMUST00000062902.3 ENSMUST00000062902.4 ENSMUST00000062902.5 ENSMUST00000062902.6 ENSMUST00000062902.7 NR_189008 uc290rct.1 uc290rct.2 uc290rct.3 uc290rct.1 uc290rct.2 uc290rct.3 
ENSMUST00000062904.11 Dnajc11 ENSMUST00000062904.11 DnaJ heat shock protein family (Hsp40) member C11 (from RefSeq NM_172704.3) A2A8C9 DJC11_MOUSE ENSMUST00000062904.1 ENSMUST00000062904.10 ENSMUST00000062904.2 ENSMUST00000062904.3 ENSMUST00000062904.4 ENSMUST00000062904.5 ENSMUST00000062904.6 ENSMUST00000062904.7 ENSMUST00000062904.8 ENSMUST00000062904.9 NM_172704 Q5U458 Q8BP83 Q8C1Z4 Q8C6U5 uc008vyt.1 uc008vyt.2 uc008vyt.3 uc008vyt.4 Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Mitochondrion tochondrion outer membrane ; Peripheral membrane protein Following chemical mutagenesis predicted to give rise to a transcript subject to non-sense mediated deccay, mice exhibit an autosomal recessive neuromuscular disease and abnormal mitochondrial cristae morphology. Belongs to the DNAJC11 family. Sequence=BAC41027.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; mitochondrial sorting and assembly machinery complex mitochondrion mitochondrial outer membrane mitochondrial inner membrane membrane cristae formation MICOS complex uc008vyt.1 uc008vyt.2 uc008vyt.3 uc008vyt.4 
ENSMUST00000062915.9 Gdpgp1 ENSMUST00000062915.9 GDP-D-glucose phosphorylase 1 (from RefSeq NM_178752.3) ENSMUST00000062915.1 ENSMUST00000062915.2 ENSMUST00000062915.3 ENSMUST00000062915.4 ENSMUST00000062915.5 ENSMUST00000062915.6 ENSMUST00000062915.7 ENSMUST00000062915.8 GDPP1_MOUSE NM_178752 Q3TLS3 Q3UP89 Q8C3L2 Q8C3Y3 Q8CI49 uc009hzu.1 uc009hzu.2 uc009hzu.3 Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. Reaction=GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+); Xref=Rhea:RHEA:30387, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189, ChEBI:CHEBI:58601, ChEBI:CHEBI:62230; EC=2.7.7.78; Cytoplasm Highly expressed in the nervous and male reproductive systems compared to kidney, liver and heart. The orthologs in A.thaliana are GDP-L-galactose phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants. Belongs to the GDPGP1 family. Sequence=BAC39476.1; Type=Frameshift; Evidence=; nucleotide binding guanyl-nucleotide exchange factor activity cytoplasm glucose metabolic process transferase activity nucleotidyltransferase activity hydrolase activity GDP-D-glucose phosphorylase activity uc009hzu.1 uc009hzu.2 uc009hzu.3 
ENSMUST00000062931.2 Gjd3 ENSMUST00000062931.2 gap junction protein, delta 3 (from RefSeq NM_178596.3) CXD3_MOUSE ENSMUST00000062931.1 Gja11 Gjc1 NM_178596 Q80ZH0 Q91YD1 uc007lib.1 uc007lib.2 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Cell membrane ; Multi-pass membrane protein Cell junction, gap junction Belongs to the connexin family. Delta-type subfamily. ion channel activity gap junction channel activity plasma membrane gap junction connexin complex cell communication response to glucose cell surface membrane integral component of membrane gap junction assembly cell junction ion transmembrane transport transmembrane transport AV node cell to bundle of His cell communication by electrical coupling gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling uc007lib.1 uc007lib.2 
ENSMUST00000062944.7 Gja8 ENSMUST00000062944.7 gap junction protein, alpha 8 (from RefSeq NM_008123.3) Cxnl ENSMUST00000062944.1 ENSMUST00000062944.2 ENSMUST00000062944.3 ENSMUST00000062944.4 ENSMUST00000062944.5 ENSMUST00000062944.6 Gja8 NM_008123 Q548M7 Q548M7_MOUSE uc008qon.1 uc008qon.2 uc008qon.3 uc008qon.4 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Cell junction, gap junction Cell membrane ; Multi- pass membrane protein mbrane ; Multi-pass membrane protein Belongs to the connexin family. Alpha-type (group II) subfamily. gap junction channel activity plasma membrane integral component of plasma membrane gap junction connexin complex cell communication cell-cell signaling membrane integral component of membrane cell junction protein homooligomerization transmembrane transport gap junction-mediated intercellular transport uc008qon.1 uc008qon.2 uc008qon.3 uc008qon.4 
ENSMUST00000062945.12 Bcl2l15 ENSMUST00000062945.12 BCLl2-like 15, transcript variant 1 (from RefSeq NM_001142959.1) A1A5A5 B0V3P5 B2L15_MOUSE ENSMUST00000062945.1 ENSMUST00000062945.10 ENSMUST00000062945.11 ENSMUST00000062945.2 ENSMUST00000062945.3 ENSMUST00000062945.4 ENSMUST00000062945.5 ENSMUST00000062945.6 ENSMUST00000062945.7 ENSMUST00000062945.8 ENSMUST00000062945.9 Gm566 NM_001142959 Q08ED0 Q8K186 uc008qts.1 uc008qts.2 uc008qts.3 Sequence=AAH27668.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI17781.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI17782.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI28506.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI28507.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleus cytosol biological_process regulation of apoptotic process uc008qts.1 uc008qts.2 uc008qts.3 
ENSMUST00000062957.8 Ttc7b ENSMUST00000062957.8 tetratricopeptide repeat domain 7B, transcript variant 4 (from RefSeq NM_001413292.1) E9Q6P5 ENSMUST00000062957.1 ENSMUST00000062957.2 ENSMUST00000062957.3 ENSMUST00000062957.4 ENSMUST00000062957.5 ENSMUST00000062957.6 ENSMUST00000062957.7 NM_001413292 TTC7B_MOUSE Ttc7b uc007oss.1 uc007oss.2 uc007oss.3 uc007oss.4 Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions. Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2). Interacts with PI4KA, interaction is direct. Interacts with EFR3 (EFR3A or EFR3B), interaction is direct. Interacts with HYCC (HYCC1 or HYCC2), interaction is direct. Association with the PI4K complex is strongly reduced by TMEM150A. Cytoplasm, cytosol Cell membrane Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with EFR3 (EFR3A or EFR3B). molecular_function cytoplasm cytosol plasma membrane membrane phosphatidylinositol phosphorylation protein localization to plasma membrane uc007oss.1 uc007oss.2 uc007oss.3 uc007oss.4 
ENSMUST00000062962.12 Slc35f6 ENSMUST00000062962.12 solute carrier family 35, member F6 (from RefSeq NM_175675.3) ENSMUST00000062962.1 ENSMUST00000062962.10 ENSMUST00000062962.11 ENSMUST00000062962.2 ENSMUST00000062962.3 ENSMUST00000062962.4 ENSMUST00000062962.5 ENSMUST00000062962.6 ENSMUST00000062962.7 ENSMUST00000062962.8 ENSMUST00000062962.9 NM_175675 Q3UB33 Q8BKN1 Q8VE96 Q9D5B2 S35F6_MOUSE uc008wvs.1 uc008wvs.2 uc008wvs.3 uc008wvs.4 Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity). Interacts with SLC25A5. Mitochondrion Lysosome membrane ; Multi-pass membrane protein Belongs to the SLC35F solute transporter family. Sequence=BAB29891.1; Type=Frameshift; Evidence=; molecular_function nucleoplasm mitochondrion lysosome lysosomal membrane cytosol positive regulation of cell proliferation membrane integral component of membrane transmembrane transporter activity intracellular membrane-bounded organelle transmembrane transport negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway uc008wvs.1 uc008wvs.2 uc008wvs.3 uc008wvs.4 
ENSMUST00000062967.10 Bicdl2 ENSMUST00000062967.10 BICD family like cargo adaptor 2 (from RefSeq NM_153784.3) BICL2_MOUSE Bicdr2 Ccdc64b ENSMUST00000062967.1 ENSMUST00000062967.2 ENSMUST00000062967.3 ENSMUST00000062967.4 ENSMUST00000062967.5 ENSMUST00000062967.6 ENSMUST00000062967.7 ENSMUST00000062967.8 ENSMUST00000062967.9 NM_153784 Q8CB50 Q8CHW5 uc008asr.1 uc008asr.2 uc008asr.3 uc008asr.4 Interacts with RAB13. Belongs to the BICDR family. Sequence=BAC29578.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cell cytoplasm Rab GTPase binding vesicle transport along microtubule Golgi to secretory granule transport uc008asr.1 uc008asr.2 uc008asr.3 uc008asr.4 
ENSMUST00000062978.7 BC030500 ENSMUST00000062978.7 cDNA sequence BC030500 (from RefSeq NM_173411.2) BC030500 ENSMUST00000062978.1 ENSMUST00000062978.2 ENSMUST00000062978.3 ENSMUST00000062978.4 ENSMUST00000062978.5 ENSMUST00000062978.6 NM_173411 Q8K0R8 Q8K0R8_MOUSE uc009ltd.1 uc009ltd.2 molecular_function cellular_component biological_process uc009ltd.1 uc009ltd.2 
ENSMUST00000062990.4 Slfnl1 ENSMUST00000062990.4 schlafen like 1, transcript variant 1 (from RefSeq NM_177570.4) ENSMUST00000062990.1 ENSMUST00000062990.2 ENSMUST00000062990.3 NM_177570 Q149Q6 Q8BHW9 SLNL1_MOUSE uc008unh.1 uc008unh.2 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BHW9-1; Sequence=Displayed; Name=2; IsoId=Q8BHW9-2; Sequence=VSP_024279; Belongs to the Schlafen family. Subgroup I subfamily. nucleotide binding molecular_function ATP binding cellular_component biological_process uc008unh.1 uc008unh.2 
ENSMUST00000062991.9 Grpel2 ENSMUST00000062991.9 GrpE-like 2, mitochondrial (from RefSeq NM_021296.2) ENSMUST00000062991.1 ENSMUST00000062991.2 ENSMUST00000062991.3 ENSMUST00000062991.4 ENSMUST00000062991.5 ENSMUST00000062991.6 ENSMUST00000062991.7 ENSMUST00000062991.8 Grpel2 NM_021296 Q0VB85 Q0VB85_MOUSE uc008fco.1 uc008fco.2 uc008fco.3 uc008fco.4 Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Mitochondrion matrix Belongs to the GrpE family. adenyl-nucleotide exchange factor activity mitochondrion mitochondrial matrix protein folding protein homodimerization activity regulation of catalytic activity chaperone binding uc008fco.1 uc008fco.2 uc008fco.3 uc008fco.4 
ENSMUST00000063031.4 Or6c38 ENSMUST00000063031.4 olfactory receptor family 6 subfamily C member 38 (from RefSeq NM_146864.1) ENSMUST00000063031.1 ENSMUST00000063031.2 ENSMUST00000063031.3 NM_146864 Olfr768 Or6c38 Q8VGC4 Q8VGC4_MOUSE uc007hpj.1 uc007hpj.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hpj.1 uc007hpj.2 
ENSMUST00000063042.11 Glb1 ENSMUST00000063042.11 galactosidase, beta 1, transcript variant 3 (from RefSeq NR_108102.1) ENSMUST00000063042.1 ENSMUST00000063042.10 ENSMUST00000063042.2 ENSMUST00000063042.3 ENSMUST00000063042.4 ENSMUST00000063042.5 ENSMUST00000063042.6 ENSMUST00000063042.7 ENSMUST00000063042.8 ENSMUST00000063042.9 Glb1 NR_108102 Q3TAW7 Q3TAW7_MOUSE uc009rxm.1 uc009rxm.2 uc009rxm.3 uc009rxm.4 uc009rxm.5 This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a lysosomal enzyme that catalyzes the hydrolysis of terminal beta-D-galactose residues in various substrates like lactose, ganglioside GM1 and other glycoproteins. Mutations in the human gene are associated with GM1-gangliosidosis and Morquio B syndrome. Disruption of the mouse gene mirrors the symptoms of human gangliosidosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.; EC=3.2.1.23; Evidence=; Belongs to the glycosyl hydrolase 35 family. hydrolase activity, hydrolyzing O-glycosyl compounds beta-galactosidase activity cytoplasm lysosome Golgi apparatus carbohydrate metabolic process metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds galactoside binding galactose catabolic process protein homodimerization activity intracellular membrane-bounded organelle cellular carbohydrate metabolic process response to cortisone response to Thyroglobulin triiodothyronine uc009rxm.1 uc009rxm.2 uc009rxm.3 uc009rxm.4 uc009rxm.5 
ENSMUST00000063062.9 Chil3 ENSMUST00000063062.9 chitinase-like 3 (from RefSeq NM_009892.4) CHIL3_MOUSE Chi3l3 ENSMUST00000063062.1 ENSMUST00000063062.2 ENSMUST00000063062.3 ENSMUST00000063062.4 ENSMUST00000063062.5 ENSMUST00000063062.6 ENSMUST00000063062.7 ENSMUST00000063062.8 NM_009892 O35744 P70201 Q3U462 Q3UV87 Q61201 Ym1 uc008qvw.1 uc008qvw.2 uc008qvw.3 The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is thought to function as a lectin and may be involved in inflammation and allergy. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061154.1, AK137503.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849387 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy. Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52; Evidence=; Kinetic parameters: KM=120.8 uM for 4-methylumbelliferone-N-acetylglucosamine (at pH 4- 4.5) ; Vmax=0.023 umol/min/mg enzyme ; Note=4-methylumbelliferone-N-acetylglucosamine (MU-(GlcNAc)1) is a GlcNAc2 analog.; pH dependence: Optimum pH is 4.5-5.0. ; Secreted. Rough endoplasmic reticulum lumen. Nucleus envelope. Cytoplasm. Cytoplasmic granule. Note=Predominantly localizes to the lumen of rough endoplasmic reticulum (rER) and nuclear envelope in alveolar macrophages. Localizes to the dilated lumen of rER in immature neutrophils in spleen and in cytoplasmic granules in peritoneal neutrophils. Detected in needle-shaped crystals present in the cytoplasm of bone marrow macrophages. Expressed in peritoneal cavity macrophages and in peritoneal and bone marrow-derived neutrophils. Abundantly expressed in bone marrow, with moderate levels detected in gastric antrum, spleen and in alveolar macrophages in lung. Not detected in brain, heart, liver, kidney, stomach, intestine, skeletal muscle, ovary, testis, thymus and lymph nodes (at protein level). Detected at low levels in bone marrow, spleen, thymus and lung. Barely detectable in intestine, kidney and coecum. In yolk sac, first detected at low levels at 8.5 dpc, with significant expression detected at 10.5 dpc in myeloid precursor cells. In liver, expressed from 16.5 dpc to P7.5 with highest levels detected from 18.5 dpc to P0.5. In spleen, first detected at 16.5 dpc, with peak levels detected at 18.5 dpc and P0.5 and expression persisting through the spleen maturation to the adult stage. In bone marrow, high expression levels detected from 16.5 dpc until adulthood. In lung, first detected around the time of birth, with levels increasing significantly from P14.5 towards adulthood. Up-regulated in response to IL3 and IL4, during the inflammatory response and upon parasitic infection. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. polysaccharide catabolic process beta-N-acetylhexosaminidase activity chitinase activity extracellular region nucleus nuclear envelope cytoplasm endoplasmic reticulum carbohydrate metabolic process chitin catabolic process inflammatory response chitin binding metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds carbohydrate binding cytoplasmic vesicle rough endoplasmic reticulum lumen uc008qvw.1 uc008qvw.2 uc008qvw.3 
ENSMUST00000063063.14 Scml4 ENSMUST00000063063.14 Scm polycomb group protein like 4, transcript variant 2 (from RefSeq NM_172938.3) ENSMUST00000063063.1 ENSMUST00000063063.10 ENSMUST00000063063.11 ENSMUST00000063063.12 ENSMUST00000063063.13 ENSMUST00000063063.2 ENSMUST00000063063.3 ENSMUST00000063063.4 ENSMUST00000063063.5 ENSMUST00000063063.6 ENSMUST00000063063.7 ENSMUST00000063063.8 ENSMUST00000063063.9 NM_172938 Q3TA16 Q3V358 Q5DU61 Q80VG1 Q8CC08 SCML4_MOUSE uc011xdi.1 uc011xdi.2 uc011xdi.3 Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80VG1-1; Sequence=Displayed; Name=2; IsoId=Q80VG1-2; Sequence=VSP_033947; Belongs to the SCM family. molecular_function nucleus nucleoplasm biological_process uc011xdi.1 uc011xdi.2 uc011xdi.3 
ENSMUST00000063076.6 Htr1f ENSMUST00000063076.6 5-hydroxytryptamine (serotonin) receptor 1F (from RefSeq NM_008310.3) ENSMUST00000063076.1 ENSMUST00000063076.2 ENSMUST00000063076.3 ENSMUST00000063076.4 ENSMUST00000063076.5 Htr1f NM_008310 Q543V2 Q543V2_MOUSE uc007zqg.1 uc007zqg.2 uc007zqg.3 uc007zqg.4 G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway membrane integral component of membrane serotonin binding uc007zqg.1 uc007zqg.2 uc007zqg.3 uc007zqg.4 
ENSMUST00000063089.12 Nsun3 ENSMUST00000063089.12 NOL1/NOP2/Sun domain family member 3, transcript variant 1 (from RefSeq NM_178925.4) ENSMUST00000063089.1 ENSMUST00000063089.10 ENSMUST00000063089.11 ENSMUST00000063089.2 ENSMUST00000063089.3 ENSMUST00000063089.4 ENSMUST00000063089.5 ENSMUST00000063089.6 ENSMUST00000063089.7 ENSMUST00000063089.8 ENSMUST00000063089.9 NM_178925 NSUN3_MOUSE Nsun3 Q3TE43 Q8CCT7 uc007zps.1 uc007zps.2 uc007zps.3 Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt- tRNA(Met). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5- formylcytosine (f(5)c) at this position. mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation. Reaction=cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine = 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:53076, Rhea:RHEA-COMP:13451, Rhea:RHEA- COMP:13453, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53077; Evidence=; Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CCT7-1; Sequence=Displayed; Name=2; IsoId=Q8CCT7-2; Sequence=VSP_025970; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. tRNA binding wobble base cytosine methylation RNA binding mitochondrion mitochondrial matrix mitochondrial large ribosomal subunit methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity transferase activity rRNA methylation methylation regulation of mitochondrial translation uc007zps.1 uc007zps.2 uc007zps.3 
ENSMUST00000063112.4 Defb6 ENSMUST00000063112.4 defensin beta 6 (from RefSeq NM_054074.1) DEFB6_MOUSE ENSMUST00000063112.1 ENSMUST00000063112.2 ENSMUST00000063112.3 NM_054074 Q91VD6 uc009lal.1 uc009lal.2 Has potent antibacterial activity against E.coli (ATCC 25922). Secreted. Predominantly expressed in skeletal muscle, also expressed in esophagus, tongue, and trachea. Also expressed in lung when induced by lipopolysaccharide. Expressed constitutively and induced by lipopolysaccharide (LPS). Belongs to the beta-defensin family. extracellular region extracellular space chemotaxis defense response CCR6 chemokine receptor binding chemoattractant activity defense response to bacterium defense response to Gram-negative bacterium positive chemotaxis cell chemotaxis uc009lal.1 uc009lal.2 
ENSMUST00000063116.10 Msx1 ENSMUST00000063116.10 msh homeobox 1 (from RefSeq NM_010835.2) ENSMUST00000063116.1 ENSMUST00000063116.2 ENSMUST00000063116.3 ENSMUST00000063116.4 ENSMUST00000063116.5 ENSMUST00000063116.6 ENSMUST00000063116.7 ENSMUST00000063116.8 ENSMUST00000063116.9 Hox7 Hox7.1 MSX1_MOUSE Msx1 NM_010835 P13297 Q91W75 Q9ERF6 uc008xfw.1 uc008xfw.2 uc008xfw.3 Acts as a transcriptional repressor (PubMed:7823952, PubMed:22629437, PubMed:23371388). Capable of transcription autoinactivation (PubMed:10215616). Binds to the consensus sequence 5'- C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR (PubMed:23371388). Represses transcription of myoblast differentiation factors (PubMed:16600910, PubMed:22629437). Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1 (PubMed:16600910). Recruits histone H3 methyltransferases such as EHMT2/G9a to gene promoter regions which leads to inhibition of myoblast differentiation via transcriptional repression of differentiation factors (PubMed:22629437). Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells (PubMed:7914451, PubMed:8898217, PubMed:24028588, PubMed:27713059, PubMed:29148101). At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells (PubMed:8898217). May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme (PubMed:27713059). Required for BMP4 expression in dental mesenchyme cells (PubMed:8898217). Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells (PubMed:8898217). Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells (PubMed:8898217). Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells (PubMed:8898217). At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as an homeostatic regulator of the cell cycle (PubMed:24028588, PubMed:29148101). Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB1 and subsequent repression of the odontoblast differentiation factors BMP2, BMP4, LEF1, ALPL and BGLAP/OCN (PubMed:24028588, PubMed:29148101). Additionally, required for correct development and fusion of the palatal shelves and embryonic mandibular formation (PubMed:7914451). Plays a role in embryonic bone formation of the middle ear, skull and nasal bones (PubMed:7914451). Required for correct formation and thickness of the nail plate (PubMed:11369996). May play a role in limb-pattern formation (PubMed:1677742). Interacts with CREBBP/CBP, TBP and SP1; interaction with these transcription activators may inhibit autoinactivation (PubMed:10215616). Interacts (via homeobox domain) with EHMT2/G9a (PubMed:22629437). Interacts with EHMT1/GLP (PubMed:22629437). Interacts (via C-terminus) with PIAS1 (via N-terminus); the interaction is required for the localization of both proteins to the nuclear periphery and specific binding of MSX1 to the core enhancer region in target gene promoters (PubMed:16600910). Interacts with H1-5 (PubMed:16600910). P13297; P43276: H1-5; NbExp=3; IntAct=EBI-903969, EBI-903960; P13297; P25233: Ndn; NbExp=2; IntAct=EBI-903969, EBI-1801080; Nucleus Note=Interaction with EHMT2/G9a is required for localization to the nuclear periphery (PubMed:22629437). Interaction with PIAS1 is required for localization to the nuclear periphery (PubMed:16600910). Expressed in the developing limb bud at 11.5 dpc (at protein level) (PubMed:22629437). Expressed in the pituitary gland at 11.5 dpc, reaching peak abundance at 13.5 dpc with abundance decreasing from 15.5 dpc onwards (PubMed:23371388). Expression is most prevalent in the ventral pituitary area where developing gonadotropes reside (PubMed:23371388). Expressed in early bell stage and mid bell stage in dental mesenchymal cells at 15.5 and 17.5 dpc respectively (at protein level) (PubMed:24028588, PubMed:29148101). Expressed in the mesenchyme subjacent to the thickened epithelium of the nail bed at 16.5 and 18.5 dpc (at protein level) (PubMed:11369996). Sumoylated by PIAS1, desumoylated by SENP1 (PubMed:16678795). Sumoylation of Lys-15 and Lys-133 not required for interaction with H1- 5, transcriptional repression, inhibition of myoblast differentiation, or binding to gene promoters (PubMed:16600910). Knockout mice die shortly after birth (PubMed:7914451). Development of mesenchymal molar tooth buds is arrested at the bud stage, as a result of reduced expression of Bmp4 and Lef1 in the dental mesenchyme at 13.5 and 14.5 dpc, there is no change in expression in the dental epithelium (PubMed:8898217, PubMed:27713059). Decrease in the expression of the Wnt signaling gene Tcf7, and an increase in Dkk2, Sfrp1 and Sfrp2 in the mandibular molar tooth mesenchyme at 13.5 dpc (PubMed:27713059). Expression of Dkk2 and Sfrp2 expands into the distal tooth mesenchyme in mandibular molar tooth buds at 13.5 dpc (PubMed:27713059). Decrease in Sdc1 expression in the dental mesenchyme at 13.5 dpc (PubMed:8898217). Palatal shelves are correctly elevated however not fused with each other or with the nasal septum at 14.75 dpc (PubMed:7914451). Reduced nail bed thickness with pitting defects and irregular shape at 18.5 dpc (PubMed:11369996). Complete cleft of the secondary palate at birth, including loss of both the maxillary shelf and palatine shelf (PubMed:7914451). Absence of bone development in the premaxilla along with absent upper incisors and alveolar process (PubMed:7914451). Absence of mandibular alveolar process and incisor tooth buds, foreshortening of the distal tooth- bearing mandible, a slightly reduced overall mandibular length, and an abnormal lower border and anterior segment (PubMed:7914451). Newborn mice show retarded first and second molar teeth at the tooth bud stage with a significant reduction in the amount of condensed dental follicle and papilla mesenchyme (PubMed:7914451). The nasal bones appear more rectangular, parietal bones show a slight overlap, there is a deficiency of the medial portions of the frontal bones which results in an enlarged anterior fontanelle and sutural bone (PubMed:7914451). Failure to form of the processus brevis of the malleus with an overall reduction in height of the malleus in the middle ear (PubMed:7914451). Belongs to the Msh homeobox family. It is uncertain whether Met-1 or Met-7 is the initiator. Sequence=AAH16426.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAA32871.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAA32871.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter cell morphogenesis RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development epithelial to mesenchymal transition p53 binding heart morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation DNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development heart development muscle organ development negative regulation of cell proliferation anterior/posterior pattern specification mesenchymal cell proliferation pituitary gland development signal transduction involved in regulation of gene expression negative regulation of cell growth embryonic limb morphogenesis BMP signaling pathway positive regulation of BMP signaling pathway forebrain development midbrain development protein localization to nucleus embryonic forelimb morphogenesis embryonic hindlimb morphogenesis enhancer binding embryonic nail plate morphogenesis middle ear morphogenesis odontogenesis of dentin-containing tooth odontogenesis regulation of odontogenesis embryonic digit morphogenesis negative regulation of apoptotic process negative regulation of DNA binding sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic morphogenesis stem cell differentiation protein stabilization negative regulation of striated muscle cell differentiation cartilage development palate development face morphogenesis bone morphogenesis cartilage morphogenesis mammary gland epithelium development BMP signaling pathway involved in heart development cellular response to nicotine activation of meiosis positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of transcription regulatory region DNA binding positive regulation of mesenchymal cell apoptotic process uc008xfw.1 uc008xfw.2 uc008xfw.3 
ENSMUST00000063117.10 Gstz1 ENSMUST00000063117.10 glutathione transferase zeta 1 (maleylacetoacetate isomerase), transcript variant 1 (from RefSeq NM_010363.4) ENSMUST00000063117.1 ENSMUST00000063117.2 ENSMUST00000063117.3 ENSMUST00000063117.4 ENSMUST00000063117.5 ENSMUST00000063117.6 ENSMUST00000063117.7 ENSMUST00000063117.8 ENSMUST00000063117.9 MAAI_MOUSE Maai NM_010363 Q9WVL0 uc007oim.1 uc007oim.2 uc007oim.3 uc007oim.4 Probable bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2- oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid (By similarity). Reaction=4-maleylacetoacetate = 4-fumarylacetoacetate; Xref=Rhea:RHEA:14817, ChEBI:CHEBI:17105, ChEBI:CHEBI:18034; EC=5.2.1.2; Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Name=glutathione; Xref=ChEBI:CHEBI:57925; Evidence=; Note=Glutathione is required for the MAAI activity. ; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6. Homodimer. Cytoplasm Expressed in liver, kidney, seminal glands and breast. Belongs to the GST superfamily. Zeta family. catalytic activity glutathione transferase activity cytoplasm mitochondrion L-phenylalanine catabolic process tyrosine catabolic process glutathione metabolic process metabolic process aromatic amino acid family metabolic process maleylacetoacetate isomerase activity transferase activity isomerase activity identical protein binding protein homodimerization activity uc007oim.1 uc007oim.2 uc007oim.3 uc007oim.4 
ENSMUST00000063119.5 Rxfp4 ENSMUST00000063119.5 relaxin family peptide receptor 4 (from RefSeq NM_181817.2) ENSMUST00000063119.1 ENSMUST00000063119.2 ENSMUST00000063119.3 ENSMUST00000063119.4 Gpr100 NM_181817 Q7TQP4 Q80UD6 RL3R2_MOUSE Rln3r2 uc008pwc.1 uc008pwc.2 High affinity receptor for INSL5. Also acts as a receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity). Cell membrane; Multi-pass membrane protein. Detected only in bone marrow. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane positive regulation of feeding behavior uc008pwc.1 uc008pwc.2 
ENSMUST00000063127.4 5430402E10Rik ENSMUST00000063127.4 RIKEN cDNA 5430402E10 gene (from RefSeq NM_027768.3) 5430402E10Rik ENSMUST00000063127.1 ENSMUST00000063127.2 ENSMUST00000063127.3 NM_027768 Q9D3N5 Q9D3N5_MOUSE uc029xlb.1 uc029xlb.2 Secreted Belongs to the calycin superfamily. Lipocalin family. odorant binding cellular_component biological_process small molecule binding uc029xlb.1 uc029xlb.2 
ENSMUST00000063132.6 Svs3b ENSMUST00000063132.6 seminal vesicle secretory protein 3B (from RefSeq NM_173377.2) ENSMUST00000063132.1 ENSMUST00000063132.2 ENSMUST00000063132.3 ENSMUST00000063132.4 ENSMUST00000063132.5 NM_173377 Q8BZH8 Q8BZH8_MOUSE Svs3 Svs3a Svs3b uc008nud.1 uc008nud.2 uc008nud.3 molecular_function cellular_component sperm capacitation uc008nud.1 uc008nud.2 uc008nud.3 
ENSMUST00000063138.8 Msl3l2 ENSMUST00000063138.8 MSL3 like 2 (from RefSeq NM_001163833.1) ENSMUST00000063138.1 ENSMUST00000063138.2 ENSMUST00000063138.3 ENSMUST00000063138.4 ENSMUST00000063138.5 ENSMUST00000063138.6 ENSMUST00000063138.7 G3X992 G3X992_MOUSE Msl3l2 NM_001163833 uc007fcb.1 uc007fcb.2 Nucleus histone acetyltransferase complex molecular_function nucleus chromatin organization chromatin silencing regulation of transcription, DNA-templated histone acetylation histone deacetylation NuA4 histone acetyltransferase complex histone H4 acetylation histone H2A acetylation histone H4-K16 acetylation MSL complex uc007fcb.1 uc007fcb.2 
ENSMUST00000063166.6 Garin3 ENSMUST00000063166.6 golgi associated RAB2 interactor 3 (from RefSeq NM_001013783.2) ENSMUST00000063166.1 ENSMUST00000063166.2 ENSMUST00000063166.3 ENSMUST00000063166.4 ENSMUST00000063166.5 Fam71b GAR3_MOUSE Garin3 NM_001013783 Q5STT6 uc007ioj.1 uc007ioj.2 uc007ioj.3 uc007ioj.4 May be involved in RNA biogenesis. Interacts (via N-terminus) with RAB2B (in GTP-bound form) (PubMed:18256213). Interacts with FRG1. Golgi apparatus Nucleus, Cajal body Expressed in adult spermatocytes and spermatids. Belongs to the GARIN family. It is uncertain whether Met-1 or Met-8 is the initiator. molecular_function nucleus biological_process uc007ioj.1 uc007ioj.2 uc007ioj.3 uc007ioj.4 
ENSMUST00000063169.10 Dleu7 ENSMUST00000063169.10 deleted in lymphocytic leukemia, 7 (from RefSeq NM_173419.2) ENSMUST00000063169.1 ENSMUST00000063169.2 ENSMUST00000063169.3 ENSMUST00000063169.4 ENSMUST00000063169.5 ENSMUST00000063169.6 ENSMUST00000063169.7 ENSMUST00000063169.8 ENSMUST00000063169.9 LEU7_MOUSE Leu7 NM_173419 Q8CHZ8 uc007ugk.1 uc007ugk.2 uc007ugk.3 uc007ugk.4 molecular_function cellular_component biological_process uc007ugk.1 uc007ugk.2 uc007ugk.3 uc007ugk.4 
ENSMUST00000063191.14 Serpinb9 ENSMUST00000063191.14 Belongs to the serpin family. Ov-serpin subfamily. (from UniProt O08797) AK161581 ENSMUST00000063191.1 ENSMUST00000063191.10 ENSMUST00000063191.11 ENSMUST00000063191.12 ENSMUST00000063191.13 ENSMUST00000063191.2 ENSMUST00000063191.3 ENSMUST00000063191.4 ENSMUST00000063191.5 ENSMUST00000063191.6 ENSMUST00000063191.7 ENSMUST00000063191.8 ENSMUST00000063191.9 O08797 O08797_MOUSE Serpinb9 uc288luu.1 uc288luu.2 Belongs to the serpin family. Ov-serpin subfamily. T cell mediated cytotoxicity protease binding acute inflammatory response to antigenic stimulus serine-type endopeptidase inhibitor activity protein binding extracellular space nucleus nucleoplasm cytoplasm Golgi apparatus cytosol apoptotic process immune response response to bacterium positive regulation of gene expression negative regulation of endopeptidase activity negative regulation by symbiont of host apoptotic process protection from natural killer cell mediated cytotoxicity defense response to bacterium cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of T cell apoptotic process uc288luu.1 uc288luu.2 
ENSMUST00000063192.15 Tmem150c ENSMUST00000063192.15 transmembrane protein 150C, transcript variant 15 (from RefSeq NR_188915.1) D3YVG3 ENSMUST00000063192.1 ENSMUST00000063192.10 ENSMUST00000063192.11 ENSMUST00000063192.12 ENSMUST00000063192.13 ENSMUST00000063192.14 ENSMUST00000063192.2 ENSMUST00000063192.3 ENSMUST00000063192.4 ENSMUST00000063192.5 ENSMUST00000063192.6 ENSMUST00000063192.7 ENSMUST00000063192.8 ENSMUST00000063192.9 NR_188915 Q3TL78 Q8C8S3 Q8K117 T150C_MOUSE Ttn3 uc008yhc.1 uc008yhc.2 uc008yhc.3 Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception (PubMed:27321926). Cell membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Note=Localizes at the plasma membrane. A portion co-localizes with LAMP1 lysosomal marker. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C8S3-1; Sequence=Displayed; Name=2; IsoId=Q8C8S3-2; Sequence=VSP_039351; High expression in the epididymis, pancreas, dorsal-root ganglion, eye, brain, and spinal cord. Expressed in muscle spindle afferents (at protein level)(PubMed:27321926). Deficient mice exhibit loss of coordinated movements and abnormal gait. Tentonin comes from the Greek 'tentono' meaning to stretch. Belongs to the DRAM/TMEM150 family. The function of the TMEM150C complex is debated. One study confirms that naive cells expressing TMEM150C is activated by mechanically stimuli but this response is absent in CRISPR-Cas9 PIEZO1 knockout cell lines suggesting that TMEM150C is not sufficient to function as mechanically activated channels but is a modulatory protein of PIEZO1 (PubMed:28426961). In another study, based on coexpression of TMEM150C and PEIZO1 and mutant variants of TMEM150C supports that TMEM150C is a pore-forming unit, and not an amplifying adapter for PIEZO1 activity (PubMed:28426962). Sequence=BAE38914.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; lysosome lysosomal membrane plasma membrane integral component of plasma membrane mechanically-gated ion channel activity regulation of autophagy membrane integral component of membrane proprioception transmembrane transport cellular response to mechanical stimulus uc008yhc.1 uc008yhc.2 uc008yhc.3 
ENSMUST00000063204.9 Fam229b ENSMUST00000063204.9 family with sequence similarity 229, member B, transcript variant 7 (from RefSeq NR_153111.1) ENSMUST00000063204.1 ENSMUST00000063204.2 ENSMUST00000063204.3 ENSMUST00000063204.4 ENSMUST00000063204.5 ENSMUST00000063204.6 ENSMUST00000063204.7 ENSMUST00000063204.8 F229B_MOUSE NR_153111 Q8CF36 uc007evr.1 uc007evr.2 uc007evr.3 uc007evr.4 Belongs to the FAM229 family. molecular_function cellular_component biological_process uc007evr.1 uc007evr.2 uc007evr.3 uc007evr.4 
ENSMUST00000063216.6 5730507C01Rik ENSMUST00000063216.6 RIKEN cDNA 5730507C01 gene, transcript variant 2 (from RefSeq NM_001033157.4) 5730507C01Rik ENSMUST00000063216.1 ENSMUST00000063216.2 ENSMUST00000063216.3 ENSMUST00000063216.4 ENSMUST00000063216.5 NM_001033157 Q3UT17 Q3UT17_MOUSE uc007ndb.1 uc007ndb.2 uc007ndb.3 uc007ndb.4 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007ndb.1 uc007ndb.2 uc007ndb.3 uc007ndb.4 
ENSMUST00000063219.3 Pabpc2 ENSMUST00000063219.3 poly(A) binding protein, cytoplasmic 2 (from RefSeq NM_011033.2) ENSMUST00000063219.1 ENSMUST00000063219.2 NM_011033 Pabpc2 Q62029 Q62029_MOUSE uc008etc.1 uc008etc.2 Binds the poly(A) tail of mRNA. Cytoplasm Nucleus Belongs to the polyadenylate-binding protein type-1 family. nucleic acid binding RNA binding mRNA 3'-UTR binding nucleus cytoplasm cytosol mRNA polyadenylation poly(A) binding poly(U) RNA binding cytoplasmic stress granule ribonucleoprotein complex uc008etc.1 uc008etc.2 
ENSMUST00000063251.3 Wfdc15a ENSMUST00000063251.3 WAP four-disulfide core domain 15A (from RefSeq NM_183271.3) ENSMUST00000063251.1 ENSMUST00000063251.2 NM_183271 Q8BH89 WF15A_MOUSE Wfdc15a uc008nty.1 uc008nty.2 uc008nty.3 Antibacterial protein. Secreted molecular_function cellular_component extracellular region biological_process negative regulation of peptidase activity peptidase inhibitor activity defense response to bacterium uc008nty.1 uc008nty.2 uc008nty.3 
ENSMUST00000063263.5 Iqcj ENSMUST00000063263.5 IQ motif containing J (from RefSeq NM_177585.3) ENSMUST00000063263.1 ENSMUST00000063263.2 ENSMUST00000063263.3 ENSMUST00000063263.4 IQCJ_MOUSE Iqcj NM_177585 Q8BPW0 uc008plq.1 uc008plq.2 Event=Alternative splicing; Named isoforms=3; Name=Iqcj-1; IsoId=Q8BPW0-1; Sequence=Displayed; Name=Iqcj-schip1-1; Synonyms=IQCJ-SCHIP-1; IsoId=A0A088MLT8-1; Sequence=External; Name=Iqcj-schip1-2; IsoId=A0A088MLT8-2; Sequence=External; molecular_function cellular_component biological_process uc008plq.1 uc008plq.2 
ENSMUST00000063272.13 Tmem175 ENSMUST00000063272.13 transmembrane protein 175, transcript variant 6 (from RefSeq NM_001359427.1) ENSMUST00000063272.1 ENSMUST00000063272.10 ENSMUST00000063272.11 ENSMUST00000063272.12 ENSMUST00000063272.2 ENSMUST00000063272.3 ENSMUST00000063272.4 ENSMUST00000063272.5 ENSMUST00000063272.6 ENSMUST00000063272.7 ENSMUST00000063272.8 ENSMUST00000063272.9 NM_001359427 Q3TDC4 Q99K00 Q9CXY1 TM175_MOUSE Tmem175 uc008yoq.1 uc008yoq.2 uc008yoq.3 uc008yoq.4 Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (PubMed:35750034). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (By similarity). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (PubMed:26317472). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (PubMed:26317472, PubMed:33505021). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (PubMed:33505021). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (PubMed:33505021). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:33505021). Reaction=H(+)(in) = H(+)(out); Xref=Rhea:RHEA:34979, ChEBI:CHEBI:15378; Evidence=; Reaction=K(+)(in) = K(+)(out); Xref=Rhea:RHEA:29463, ChEBI:CHEBI:29103; Evidence=; Active at low pH (under pH 4.6): proton channel activity is activated by luminal side protons (By similarity). Polyunsaturated fatty acids, such as arachidonic acid, also activate the channel activity (By similarity). Proton channel activity is directly inhibited by LAMP1 or LAMP2, facilitating lysosomal acidification (By similarity). Channel activity is activated following interaction with AKT (AKT1, AKT2 or AKT3): interaction promotes activation from closed to an open state (PubMed:33505021). Activation by AKT is independent of AKT serine/threonine-protein kinase activity (PubMed:33505021). Homodimer (By similarity). Interacts with AKT (AKT1, AKT2 or AKT3); leading to formation of the lysoK(GF) complex, which activates the channel (PubMed:33505021). Interacts with LAMP1; inhibiting the proton channel activity of TMEM175 (By similarity). Interacts with LAMP2; inhibiting the proton channel activity of TMEM175 (By similarity). Endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Composed of two modules of six transmembranes, forming a homodimer with a tetrameric architecture. The six transmembrane regions of each module are tightly packed within each subunit without undergoing domain swapping. Forms a central ion-conduction pore lined by the side chains of the pore-lining helices. Conserved isoleucine residues (Ile-43 in the first module and Ile-268 in the second module) in the center of the pore serve as the gate in the closed conformation. In the widened channel in the open conformation, the same residues establish a constriction essential for potassium selectivity. Mice display accelerated loss of dopaminergic neurons and impaired motor skills (PubMed:33505021). Knockout neurons show increased damage in response to insults and an accumulation of alpha-synuclein (PubMed:33505021, PubMed:35750034). The accumulation of alpha-synuclein leads to increased damage to the integrity of lysosomal membranes (PubMed:33505021, PubMed:35750034). Belongs to the TMEM175 family. potassium channel activity lysosome lysosomal membrane endosome ion transport potassium ion transport endosome membrane membrane integral component of membrane potassium ion leak channel activity regulation of lysosomal lumen pH potassium ion transmembrane transport phagosome-lysosome fusion uc008yoq.1 uc008yoq.2 uc008yoq.3 uc008yoq.4 
ENSMUST00000063289.4 Or8s5 ENSMUST00000063289.4 olfactory receptor family 8 subfamily S member 5 (from RefSeq NM_146281.1) ENSMUST00000063289.1 ENSMUST00000063289.2 ENSMUST00000063289.3 NM_146281 Olfr284 Or8s5 Q8VET7 Q8VET7_MOUSE uc007xmh.1 uc007xmh.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007xmh.1 uc007xmh.2 
ENSMUST00000063292.8 Krt73 ENSMUST00000063292.8 keratin 73 (from RefSeq NM_212485.3) ENSMUST00000063292.1 ENSMUST00000063292.2 ENSMUST00000063292.3 ENSMUST00000063292.4 ENSMUST00000063292.5 ENSMUST00000063292.6 ENSMUST00000063292.7 K2C73_MOUSE Kb36 NM_212485 Q6NXH9 uc007xua.1 uc007xua.2 uc007xua.3 Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity). Heterotetramer of two type I and two type II keratins. There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively). Belongs to the intermediate filament family. intermediate filament keratin filament uc007xua.1 uc007xua.2 uc007xua.3 
ENSMUST00000063303.11 Cdkl3 ENSMUST00000063303.11 cyclin dependent kinase like 3, transcript variant 2 (from RefSeq NM_153785.4) A2ACR7 A2ACR8 A2ACR9 A2ACS0 A2ACS1 CDKL3_MOUSE Cdkl3 ENSMUST00000063303.1 ENSMUST00000063303.10 ENSMUST00000063303.2 ENSMUST00000063303.3 ENSMUST00000063303.4 ENSMUST00000063303.5 ENSMUST00000063303.6 ENSMUST00000063303.7 ENSMUST00000063303.8 ENSMUST00000063303.9 NM_153785 Q5M6W2 Q8BKR2 Q8BL49 Q8BLF2 Q8BLN9 Q8BVE0 Q8K134 uc007iuy.1 uc007iuy.2 uc007iuy.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Cytoplasm Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q8BLF2-1; Sequence=Displayed; Name=2; IsoId=Q8BLF2-2; Sequence=VSP_016154, VSP_016157; Name=3; IsoId=Q8BLF2-7; Sequence=VSP_016155, VSP_016156; Name=4; IsoId=Q8BLF2-4; Sequence=VSP_016150, VSP_016151; Name=5; IsoId=Q8BLF2-5; Sequence=VSP_016149, VSP_016155, VSP_016156; Name=6; IsoId=Q8BLF2-6; Sequence=VSP_016152; Name=7; IsoId=Q8BLF2-8; Sequence=VSP_030154; The [NKR]KIAxRE motif seems to be a cyclin-binding region. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity negative regulation of axon extension positive regulation of dendrite morphogenesis regulation of cell cycle dendrite extension uc007iuy.1 uc007iuy.2 uc007iuy.3 
ENSMUST00000063307.6 Ppargc1b ENSMUST00000063307.6 peroxisome proliferative activated receptor, gamma, coactivator 1 beta, transcript variant 2 (from RefSeq NM_001364996.1) ENSMUST00000063307.1 ENSMUST00000063307.2 ENSMUST00000063307.3 ENSMUST00000063307.4 ENSMUST00000063307.5 Errl1 NM_001364996 PRGC2_MOUSE Pgc1 Pgc1b Ppargc1 Q8C1C0 Q8VHJ7 uc012bdq.1 uc012bdq.2 uc012bdq.3 Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Interacts with estrogen receptor alpha/ESR1 (By similarity). Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VHJ7-1; Sequence=Displayed; Name=2; IsoId=Q8VHJ7-2; Sequence=VSP_019302; Ubiquitous with higher expression in heart, brown adipose tissue, brain and skeletal muscle. Induced by fasting in the liver, but not by cold exposure in brown adipose tissue. Induced also by saturated fatty acids in primary hepatocytes. Contains 3 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors. Transgenic mice overexpressing PPARGC1B exhibits increased expression of medium-chain acyl CoA dehydrogenase. They are hyperphagic but lean, with increased energy expenditure and resistance to obesity. ossification nucleic acid binding transcription cofactor activity RNA binding protein binding nucleus nucleoplasm mitochondrion regulation of transcription, DNA-templated transcription from mitochondrial promoter actin filament organization transcription factor binding positive regulation of alkaline phosphatase activity mediator complex estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity intracellular estrogen receptor signaling pathway cellular response to reactive oxygen species positive regulation of phosphorylation positive regulation of osteoclast differentiation positive regulation of bone resorption negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter AF-2 domain binding positive regulation of sequence-specific DNA binding transcription factor activity response to glucocorticoid response to cAMP bone trabecula formation uc012bdq.1 uc012bdq.2 uc012bdq.3 
ENSMUST00000063317.4 Adam6b ENSMUST00000063317.4 a disintegrin and metallopeptidase domain 6B (from RefSeq NM_001009545.1) Adam6b ENSMUST00000063317.1 ENSMUST00000063317.2 ENSMUST00000063317.3 NM_001009545 Q6IMH7 Q6IMH7_MOUSE uc007pgv.1 uc007pgv.2 uc007pgv.3 Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function metalloendopeptidase activity cellular_component proteolysis biological_process metallopeptidase activity membrane integral component of membrane uc007pgv.1 uc007pgv.2 uc007pgv.3 
ENSMUST00000063324.14 Cox6b2 ENSMUST00000063324.14 cytochrome c oxidase subunit 6B2, transcript variant 6 (from RefSeq NR_110411.1) CX6B2_MOUSE ENSMUST00000063324.1 ENSMUST00000063324.10 ENSMUST00000063324.11 ENSMUST00000063324.12 ENSMUST00000063324.13 ENSMUST00000063324.2 ENSMUST00000063324.3 ENSMUST00000063324.4 ENSMUST00000063324.5 ENSMUST00000063324.6 ENSMUST00000063324.7 ENSMUST00000063324.8 ENSMUST00000063324.9 NR_110411 Q3KNG2 Q80ZN9 uc009eym.1 uc009eym.2 uc009eym.3 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Energy metabolism; oxidative phosphorylation. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side Testis specific. Belongs to the cytochrome c oxidase subunit 6B family. mitochondrion biological_process mitochondrial crista uc009eym.1 uc009eym.2 uc009eym.3 
ENSMUST00000063339.14 Rarg ENSMUST00000063339.14 retinoic acid receptor, gamma, transcript variant 2 (from RefSeq NM_001042727.3) ENSMUST00000063339.1 ENSMUST00000063339.10 ENSMUST00000063339.11 ENSMUST00000063339.12 ENSMUST00000063339.13 ENSMUST00000063339.2 ENSMUST00000063339.3 ENSMUST00000063339.4 ENSMUST00000063339.5 ENSMUST00000063339.6 ENSMUST00000063339.7 ENSMUST00000063339.8 ENSMUST00000063339.9 NM_001042727 Nr1b3 P18911 P20787 Q3UG86 Q62149 Q91VK5 Q91YX2 RARG_MOUSE uc007xvc.1 uc007xvc.2 uc007xvc.3 uc007xvc.4 Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function. Homodimer (By similarity). Heterodimer with a RXR molecule (By similarity). Binds DNA preferentially as a RAR/RXR heterodimer (By similarity). Forms a complex with PUS1 and the SRA1 RNA in the nucleus. P18911; Q91XC0: Ajuba; NbExp=2; IntAct=EBI-8053650, EBI-1565930; Nucleus toplasm Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=P18911-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P18911-2, P20787-1; Sequence=VSP_031082; Name=3; IsoId=P18911-3; Sequence=VSP_031081; In 9.5-12.5 dpc embryos, expression throughout limb bud mesenchyme. This expression overlaps with that of CYP26B1. Also strongly expressed in the caudal and craniofacial regions. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Rarg and Rarb double null mice exhibit growth retardation 3 weeks after birth. Defects are found in the growth plates with deficiency in cartilage. Growth retardation was noticable in limb sketal elements such as femurs. Early lethality and male sterility due to squamous metaplasia of the seminal vesicles and prostate are also observed. Isoform 2 mutants appear normal. The Rarg and Cyp26b1 double null mutation is able to partially rescue limb skeletal morphology without restoring normal expression of proximo-distal patterning genes. Belongs to the nuclear hormone receptor family. NR1 subfamily. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding neural tube closure chondrocyte development glandular epithelial cell development retinal pigment epithelium development growth plate cartilage development growth plate cartilage chondrocyte growth DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm regulation of transcription, DNA-templated multicellular organism development transcription factor binding zinc ion binding positive regulation of cell proliferation negative regulation of cell proliferation hormone-mediated signaling pathway anterior/posterior pattern specification regulation of gene expression positive regulation of gene expression cell differentiation ligand-dependent nuclear receptor transcription coactivator activity embryonic camera-type eye development regulation of myelination negative regulation of chondrocyte differentiation response to retinoic acid response to lipid embryonic hindlimb morphogenesis multicellular organism growth signaling receptor activity camera-type eye development positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death steroid hormone mediated signaling pathway sequence-specific DNA binding negative regulation of cell differentiation regulation of myeloid cell differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding retinoid X receptor binding embryonic eye morphogenesis retinoic acid receptor signaling pathway reproductive structure development gland development retina development in camera-type eye limb development face development bone development bone morphogenesis epithelium development trachea cartilage development prostate gland epithelium morphogenesis negative regulation of cartilage development Harderian gland development cellular response to retinoic acid RNA polymerase II transcription factor complex cellular response to leukemia inhibitory factor nuclear chromatin uc007xvc.1 uc007xvc.2 uc007xvc.3 uc007xvc.4 
ENSMUST00000063340.12 Rhox2a ENSMUST00000063340.12 reproductive homeobox 2A, transcript variant 1 (from RefSeq NM_029203.2) ENSMUST00000063340.1 ENSMUST00000063340.10 ENSMUST00000063340.11 ENSMUST00000063340.2 ENSMUST00000063340.3 ENSMUST00000063340.4 ENSMUST00000063340.5 ENSMUST00000063340.6 ENSMUST00000063340.7 ENSMUST00000063340.8 ENSMUST00000063340.9 NM_029203 Q9D4Y3 Q9D4Y3_MOUSE Rhox2a Rhox2e uc009sym.1 uc009sym.2 uc009sym.3 Nucleus negative regulation of transcription from RNA polymerase II promoter molecular_function DNA binding cellular_component nucleus biological_process uc009sym.1 uc009sym.2 uc009sym.3 
ENSMUST00000063359.8 Gypa ENSMUST00000063359.8 glycophorin A (from RefSeq NM_010369.3) ENSMUST00000063359.1 ENSMUST00000063359.2 ENSMUST00000063359.3 ENSMUST00000063359.4 ENSMUST00000063359.5 ENSMUST00000063359.6 ENSMUST00000063359.7 Gypa NM_010369 Q3TZH8 Q3TZH8_MOUSE uc009miz.1 uc009miz.2 uc009miz.3 Belongs to the glycophorin-A family. membrane integral component of membrane uc009miz.1 uc009miz.2 uc009miz.3 
ENSMUST00000063376.10 B230319C09Rik ENSMUST00000063376.10 RIKEN cDNA B230319C09 gene (from RefSeq NR_028382.1) ENSMUST00000063376.1 ENSMUST00000063376.2 ENSMUST00000063376.3 ENSMUST00000063376.4 ENSMUST00000063376.5 ENSMUST00000063376.6 ENSMUST00000063376.7 ENSMUST00000063376.8 ENSMUST00000063376.9 NR_028382 uc012enz.1 uc012enz.2 uc012enz.1 uc012enz.2 
ENSMUST00000063384.4 Rtl8c ENSMUST00000063384.4 retrotransposon Gag like 8C (from RefSeq NM_028375.3) Cxx1c ENSMUST00000063384.1 ENSMUST00000063384.2 ENSMUST00000063384.3 NM_028375 Q9D6I0 Q9D6I0_MOUSE Rtl8c uc033jpx.1 uc033jpx.2 uc033jpx.3 molecular_function cellular_component biological_process uc033jpx.1 uc033jpx.2 uc033jpx.3 
ENSMUST00000063414.9 Tbc1d22a ENSMUST00000063414.9 TBC1 domain family, member 22a, transcript variant 1 (from RefSeq NM_145476.3) D15Ertd781e ENSMUST00000063414.1 ENSMUST00000063414.2 ENSMUST00000063414.3 ENSMUST00000063414.4 ENSMUST00000063414.5 ENSMUST00000063414.6 ENSMUST00000063414.7 ENSMUST00000063414.8 NM_145476 Q3U268 Q3U3T0 Q8CA49 Q8R5A6 TB22A_MOUSE uc007xea.1 uc007xea.2 May act as a GTPase-activating protein for Rab family protein(s). Homodimer. Interacts with ACBD3 and ARFGEF1. Interacts with YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R5A6-1; Sequence=Displayed; Name=2; IsoId=Q8R5A6-2; Sequence=VSP_016761; Sequence=AAH23106.1; Type=Erroneous initiation; Evidence=; GTPase activator activity cell intracellular protein transport Rab GTPase binding protein homodimerization activity 14-3-3 protein binding activation of GTPase activity uc007xea.1 uc007xea.2 
ENSMUST00000063417.11 Srsf7 ENSMUST00000063417.11 serine and arginine-rich splicing factor 7, transcript variant 10 (from RefSeq NR_175815.1) ENSMUST00000063417.1 ENSMUST00000063417.10 ENSMUST00000063417.2 ENSMUST00000063417.3 ENSMUST00000063417.4 ENSMUST00000063417.5 ENSMUST00000063417.6 ENSMUST00000063417.7 ENSMUST00000063417.8 ENSMUST00000063417.9 NR_175815 Q8BL97 Q8BMC6 Q8BUR2 Q8R2N4 Q8R3E9 Q91YS1 SRSF7_MOUSE Sfrs7 uc008dqq.1 uc008dqq.2 uc008dqq.3 Required for pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi- sequence specific (By similarity). Found in large molecular weight complexes containing CCNL1 and the p110 isoforms of either CDC2L1 or CDC2L2 (By similarity). Interacts with CCNL2 and CPSF6. Interacts with NXF1 (By similarity). Interacts with YTHDC1 (PubMed:29799838). Q8BL97; Q6PFR5: Tra2a; NbExp=4; IntAct=EBI-913123, EBI-913075; Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=4; Comment=Isoforms, lacking all or part of the RS domain, may be involved in modulating Srsf7 function.; Name=1; IsoId=Q8BL97-1; Sequence=Displayed; Name=2; IsoId=Q8BL97-2; Sequence=VSP_013654; Name=3; IsoId=Q8BL97-3; Sequence=VSP_013654, VSP_013655, VSP_013656; Name=4; IsoId=Q8BL97-4; Sequence=VSP_013654, VSP_013657; Extensively phosphorylated on serine residues in the RS domain. Belongs to the splicing factor SR family. regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding protein binding nucleus nucleoplasm cytoplasm mRNA processing zinc ion binding RNA splicing nuclear speck protein domain specific binding mRNA cis splicing, via spliceosome metal ion binding negative regulation of mRNA splicing, via spliceosome mRNA transport cellular response to leukemia inhibitory factor uc008dqq.1 uc008dqq.2 uc008dqq.3 
ENSMUST00000063425.9 Vmn2r72 ENSMUST00000063425.9 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt D3Z4N8) D3Z4N8 D3Z4N8_MOUSE E9PVN4 E9PVS7 E9Q1T0 E9Q3R2 E9Q4W3 ENSMUST00000063425.1 ENSMUST00000063425.2 ENSMUST00000063425.3 ENSMUST00000063425.4 ENSMUST00000063425.5 ENSMUST00000063425.6 ENSMUST00000063425.7 ENSMUST00000063425.8 Vmn2r66 Vmn2r72 uc012fom.1 uc012fom.2 uc012fom.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012fom.1 uc012fom.2 uc012fom.3 
ENSMUST00000063445.13 Klhdc1 ENSMUST00000063445.13 kelch domain containing 1, transcript variant 1 (from RefSeq NM_178253.6) ENSMUST00000063445.1 ENSMUST00000063445.10 ENSMUST00000063445.11 ENSMUST00000063445.12 ENSMUST00000063445.2 ENSMUST00000063445.3 ENSMUST00000063445.4 ENSMUST00000063445.5 ENSMUST00000063445.6 ENSMUST00000063445.7 ENSMUST00000063445.8 ENSMUST00000063445.9 KLDC1_MOUSE Klhdc1 NM_178253 Q0VDQ7 Q80YG3 uc007nrx.1 uc007nrx.2 uc007nrx.3 Substrate-recognition component of a Cul5-RING (CRL5) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL5(KLHDC1) complex mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine. Protein modification; protein ubiquitination. Component of a CRL5 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL5, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter KLHDC1. Cytoplasm, cytosol molecular_function cytoplasm cytosol biological_process uc007nrx.1 uc007nrx.2 uc007nrx.3 
ENSMUST00000063456.5 Spmip9 ENSMUST00000063456.5 sperm microtubule inner protein 9, transcript variant 1 (from RefSeq NM_028825.3) ENSMUST00000063456.1 ENSMUST00000063456.2 ENSMUST00000063456.3 ENSMUST00000063456.4 NM_028825 Q810N1 Q9DAG4 SMIP9_MOUSE Tex37 Tsc21 uc009cgd.1 uc009cgd.2 uc009cgd.3 Nucleus Cytoplasm Note=Present in the germ cell lineage at all stages. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DAG4-1; Sequence=Displayed; Name=2; IsoId=Q9DAG4-2; Sequence=VSP_028172; Only detected after the mouse is 35 days old. Expression increases gradually from day 35 to 6 months, and remains stable after 54 days (PubMed:17091336, PubMed:29563520). Exclusively expressed in the epididymis and testis (PubMed:17091336, PubMed:29563520). Deficeint mice are fertile and have no detectable defects in the testis/body weight ratio, epididymal sperm count, and testicular and epididymal histology. molecular_function nucleus cytoplasm biological_process uc009cgd.1 uc009cgd.2 uc009cgd.3 
ENSMUST00000063465.12 Wnt5a ENSMUST00000063465.12 wingless-type MMTV integration site family, member 5A, transcript variant 1 (from RefSeq NM_009524.4) ENSMUST00000063465.1 ENSMUST00000063465.10 ENSMUST00000063465.11 ENSMUST00000063465.2 ENSMUST00000063465.3 ENSMUST00000063465.4 ENSMUST00000063465.5 ENSMUST00000063465.6 ENSMUST00000063465.7 ENSMUST00000063465.8 ENSMUST00000063465.9 NM_009524 P22725 Q8BM17 Q8BMF9 Q8VCV6 WNT5A_MOUSE Wnt-5a uc007sug.1 uc007sug.2 uc007sug.3 uc007sug.4 Ligand for members of the frizzled family of seven transmembrane receptors (PubMed:17117926). Can activate or inhibit canonical Wnt signaling, depending on receptor context (PubMed:16602827). In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (PubMed:16602827). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration (PubMed:17117926). Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells (By similarity). Required during embryogenesis for extension of the primary anterior- posterior axis and for outgrowth of limbs and the genital tubercle (PubMed:10021340). Inhibits type II collagen expression in chondrocytes (By similarity). Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Homooligomer; disulfide-linked, leading to inactivation (PubMed:22726442). Interacts with PORCN (PubMed:10866835). Interacts with WLS (PubMed:19841259). Interacts with glypican GCP3 (By similarity). Interacts with PKD1 (via extracellular domain) (PubMed:27214281). Interacts with TMEM67 (By similarity). P22725; O35082: Kl; NbExp=2; IntAct=EBI-1570983, EBI-1570828; P22725; Q9Y5W5: WIF1; Xeno; NbExp=7; IntAct=EBI-1570983, EBI-3922719; Secreted, extracellular space, extracellular matrix Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P22725-1; Sequence=Displayed; Name=2; IsoId=P22725-2; Sequence=VSP_035595; Expressed in a gradient at the caudal end of the embryo during gastrulation and later in the distal-most aspect of several structures that extend from the body such as the limbs and genital tubercle. Glycosylation is necessary for secretion but not for activity. Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A. Mice display perinatal lethality and display gross morphological defects in outgrowing tissues. They are truncated caudally, displaying loss of the tail and a significant shortening of the anterior-posterior axis. The shape of the head is abnormal with truncated snout, mandible and tongue and reduced outgrowth of the external ear. Fore- and hindlimbs lack digits, the genital tubercle is missing and chondrocyte differentiation is inhibited. Belongs to the Wnt family. A palmitoylation site was proposed at Cys-104, but it was later shown that this cysteine is engaged in a disulfide bond. activation of MAPK activity ameboidal-type cell migration establishment of planar polarity somitogenesis positive regulation of cytokine production epithelial to mesenchymal transition neural tube closure positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation heart looping morphogenesis of an epithelium positive regulation of mesenchymal cell proliferation positive regulation of cytokine secretion involved in immune response type B pancreatic cell development pericardium morphogenesis axis elongation planar cell polarity pathway involved in axis elongation transcription factor activity, sequence-specific DNA binding receptor binding frizzled binding receptor tyrosine kinase-like orphan receptor binding cytokine activity protein binding extracellular region extracellular space cytoplasm endoplasmic reticulum lumen protein phosphorylation signal transduction Wnt signaling pathway, calcium modulating pathway JNK cascade activation of JUN kinase activity cell-cell signaling multicellular organism development determination of left/right symmetry axonogenesis axon guidance axonal fasciculation hindgut morphogenesis midgut development positive regulation of cell proliferation male gonad development anterior/posterior axis specification, embryo animal organ morphogenesis anterior/posterior pattern specification cell surface response to organic substance positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of peptidyl-threonine phosphorylation positive regulation of T cell chemotaxis positive regulation of neuron projection development Wnt signaling pathway cell migration protein domain specific binding olfactory bulb interneuron development neural tube development neurogenesis positive regulation of cell-cell adhesion cell differentiation neuron differentiation keratinocyte differentiation lung development embryonic limb morphogenesis negative regulation of BMP signaling pathway midbrain development extracellular matrix positive regulation of protein binding activation of protein kinase B activity positive regulation of interferon-gamma production positive regulation of interleukin-6 production regulation of protein localization positive regulation of peptidyl-serine phosphorylation cellular protein localization limb morphogenesis non-canonical Wnt signaling pathway post-anal tail morphogenesis chemoattraction of serotonergic neuron axon chemorepulsion of dopaminergic neuron axon non-canonical Wnt signaling pathway via JNK cascade negative regulation of fibroblast growth factor receptor signaling pathway wound healing inner ear morphogenesis embryonic digit morphogenesis positive regulation of macrophage activation negative regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JUN kinase activity positive regulation of GTPase activity transcription regulatory region DNA binding positive regulation of chemokine biosynthetic process cell fate commitment establishment of epithelial cell apical/basal polarity negative regulation of fat cell differentiation positive regulation of protein catabolic process positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of angiogenesis positive regulation of ossification positive regulation of endocytosis positive regulation of meiotic nuclear division positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade development of primary male sexual characteristics negative regulation of melanin biosynthetic process positive regulation of fibroblast proliferation paraxial mesoderm formation digestive tract morphogenesis notochord morphogenesis embryonic skeletal system development genitalia development neuron projection morphogenesis negative regulation of axon extension involved in axon guidance hypophysis morphogenesis positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of interleukin-1 beta secretion positive regulation of inflammatory response regulation of synapse organization negative chemotaxis positive regulation of NF-kappaB transcription factor activity cartilage development positive regulation of anagen negative regulation of synapse assembly convergent extension convergent extension involved in axis elongation convergent extension involved in organogenesis uterus development cervix development vagina development canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway urinary bladder development face development positive regulation of type I interferon-mediated signaling pathway lateral sprouting involved in mammary gland duct morphogenesis tube closure mesenchymal-epithelial cell signaling negative regulation of prostatic bud formation mammary gland branching involved in thelarche epithelial cell proliferation involved in mammary gland duct elongation positive regulation of response to cytokine stimulus regulation of branching involved in mammary gland duct morphogenesis planar cell polarity pathway involved in gastrula mediolateral intercalation mesodermal to mesenchymal transition involved in gastrulation positive regulation of macrophage cytokine production positive regulation of cartilage development somite development planar cell polarity pathway involved in outflow tract morphogenesis planar cell polarity pathway involved in ventricular septum morphogenesis planar cell polarity pathway involved in cardiac right atrium morphogenesis planar cell polarity pathway involved in cardiac muscle tissue morphogenesis planar cell polarity pathway involved in pericardium morphogenesis positive regulation of thymocyte apoptotic process cellular response to molecule of bacterial origin cellular response to lipopolysaccharide cellular response to calcium ion cellular response to interferon-gamma hematopoietic stem cell proliferation dopaminergic neuron differentiation cellular response to transforming growth factor beta stimulus negative regulation of mesenchymal cell proliferation primitive streak formation positive regulation of protein kinase C signaling negative regulation of canonical Wnt signaling pathway cochlea morphogenesis planar cell polarity pathway involved in neural tube closure activation of GTPase activity melanocyte proliferation postsynapse glutamatergic synapse regulation of postsynaptic cytosolic calcium ion concentration positive regulation of protein kinase C activity positive regulation of neuron death chemoattractant activity involved in axon guidance regulation of cellular protein localization positive regulation of tumor necrosis factor secretion negative regulation of cell proliferation in midbrain planar cell polarity pathway involved in axon guidance midbrain dopaminergic neuron differentiation Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation positive regulation of cell-cell adhesion mediated by cadherin positive regulation of non-canonical Wnt signaling pathway positive regulation of interleukin-8 secretion uc007sug.1 uc007sug.2 uc007sug.3 uc007sug.4 
ENSMUST00000063470.11 Ptprr ENSMUST00000063470.11 protein tyrosine phosphatase receptor type R, transcript variant 1 (from RefSeq NM_011217.2) ENSMUST00000063470.1 ENSMUST00000063470.10 ENSMUST00000063470.2 ENSMUST00000063470.3 ENSMUST00000063470.4 ENSMUST00000063470.5 ENSMUST00000063470.6 ENSMUST00000063470.7 ENSMUST00000063470.8 ENSMUST00000063470.9 NM_011217 PTPRR_MOUSE Ptp13 Q62132 Q64491 Q64492 Q9QUH9 uc007hbp.1 uc007hbp.2 uc007hbp.3 uc007hbp.4 Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Interacts with MAPKs. Q62132; P63085: Mapk1; NbExp=5; IntAct=EBI-6954051, EBI-397697; Q62132; P27361: MAPK3; Xeno; NbExp=3; IntAct=EBI-6954051, EBI-73995; [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein. [Isoform Beta]: Cytoplasm. Note=Locates to the areas within the cytoplasm. [Isoform Gamma]: Cytoplasm. Note=Locates to the areas within the cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=Alpha; Synonyms=PTPBR7; IsoId=Q62132-1; Sequence=Displayed; Name=Beta; Synonyms=PTP-SL; IsoId=Q62132-2; Sequence=VSP_005159, VSP_005160; Name=Gamma; IsoId=Q62132-3; Sequence=VSP_005161; Expressed in the heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Isoform alpha is expressed throughout the granular layer of the cerebellar but not within the Purkinje cells, also in the villi of the ileum and jejunum and both the villi and crypts of the duodenum. Isoform beta is expressed only in the Purkinje cells. Isoform gamma is expressed throughout the brain, the villi and crypts of the duodenum, jejunum and ileum and expressed at low levels in the proximal colon. Isoform gamma is the only family member developmentally expressed. Expressed throughout the brain in 15.5 day embryos and in cranial nerve cells, skeletal tissues such as neural crest-derived face bones, and the periphery of cartilaginous skeletal elements including the rib and vertebrae anlage. On day 17.5, expression was observed throughout the brain, trigeminal ganglion, cranofacial bones, oral-facial structures, cervical vertebrae, axis and the ileum. Expression continued in the vertebral column throughout ossification. Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily. Sequence=CAA82958.1; Type=Erroneous initiation; Evidence=; in utero embryonic development phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding cytoplasm cytosol plasma membrane protein dephosphorylation negative regulation of epithelial cell migration membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity protein kinase binding cell junction peptidyl-tyrosine dephosphorylation ERBB2 signaling pathway negative regulation of ERK1 and ERK2 cascade uc007hbp.1 uc007hbp.2 uc007hbp.3 uc007hbp.4 
ENSMUST00000063481.9 Trem5 ENSMUST00000063481.9 RIKEN cDNA 9830107B12 gene, transcript variant 2 (from RefSeq NM_177824.4) 9830107B12Rik D3Z5D6 D3Z5D6_MOUSE ENSMUST00000063481.1 ENSMUST00000063481.2 ENSMUST00000063481.3 ENSMUST00000063481.4 ENSMUST00000063481.5 ENSMUST00000063481.6 ENSMUST00000063481.7 ENSMUST00000063481.8 NM_177824 uc008cwt.1 uc008cwt.2 uc008cwt.3 uc008cwt.4 cell surface signaling receptor activity regulation of innate immune response uc008cwt.1 uc008cwt.2 uc008cwt.3 uc008cwt.4 
ENSMUST00000063489.4 Tas2r144 ENSMUST00000063489.4 taste receptor, type 2, member 144 (from RefSeq NM_001001453.1) ENSMUST00000063489.1 ENSMUST00000063489.2 ENSMUST00000063489.3 NM_001001453 Q7TQB8 T2R40_MOUSE T2r33 Tas2r40 Tas2r44 uc009bqn.1 uc009bqn.2 Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). Membrane; Multi-pass membrane protein. Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway taste receptor activity membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009bqn.1 uc009bqn.2 
ENSMUST00000063507.11 Mcf2 ENSMUST00000063507.11 mcf.2 transforming sequence, transcript variant 1 (from RefSeq NM_001289731.2) A2AEU1 ENSMUST00000063507.1 ENSMUST00000063507.10 ENSMUST00000063507.2 ENSMUST00000063507.3 ENSMUST00000063507.4 ENSMUST00000063507.5 ENSMUST00000063507.6 ENSMUST00000063507.7 ENSMUST00000063507.8 ENSMUST00000063507.9 Mcf2 NM_001289731 Q8BLE2 Q8BLE2_MOUSE uc009thz.1 uc009thz.2 uc009thz.3 uc009thz.4 guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding dendrite development regulation of Rho protein signal transduction intracellular signal transduction cellular response to leukemia inhibitory factor uc009thz.1 uc009thz.2 uc009thz.3 uc009thz.4 
ENSMUST00000063508.15 Gria4 ENSMUST00000063508.15 glutamate receptor, ionotropic, AMPA4 (alpha 4), transcript variant 1 (from RefSeq NM_019691.5) ENSMUST00000063508.1 ENSMUST00000063508.10 ENSMUST00000063508.11 ENSMUST00000063508.12 ENSMUST00000063508.13 ENSMUST00000063508.14 ENSMUST00000063508.2 ENSMUST00000063508.3 ENSMUST00000063508.4 ENSMUST00000063508.5 ENSMUST00000063508.6 ENSMUST00000063508.7 ENSMUST00000063508.8 ENSMUST00000063508.9 GRIA4_MOUSE Glur4 NM_019691 Q6P9M7 Q9Z2W8 uc009obp.1 uc009obp.2 uc009obp.3 uc009obp.4 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]. Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with EPB41L1 via its C-terminus (By similarity). Found in a complex with GRIA1, GRIA2, GRIA3, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 and PRKCG (By similarity). Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression. The M4 transmembrane segment mediates tetramerization and is required for cell surface expression. Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity). Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily. ionotropic glutamate receptor activity AMPA glutamate receptor activity ion channel activity protein binding plasma membrane ion transport chemical synaptic transmission glutamate receptor activity postsynaptic density ligand-gated ion channel activity membrane integral component of membrane cell junction dendrite AMPA glutamate receptor complex kainate selective glutamate receptor complex ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic signaling receptor activity identical protein binding cell projection neuronal cell body terminal bouton dendritic spine synapse postsynaptic membrane modulation of synaptic transmission positive regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential postsynaptic density membrane glutamatergic synapse integral component of postsynaptic density membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc009obp.1 uc009obp.2 uc009obp.3 uc009obp.4 
ENSMUST00000063509.11 Sult2a8 ENSMUST00000063509.11 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8, transcript variant 1 (from RefSeq NM_175250.5) 2810007J24Rik B1PQU4 ENSMUST00000063509.1 ENSMUST00000063509.10 ENSMUST00000063509.2 ENSMUST00000063509.3 ENSMUST00000063509.4 ENSMUST00000063509.5 ENSMUST00000063509.6 ENSMUST00000063509.7 ENSMUST00000063509.8 ENSMUST00000063509.9 NM_175250 Q8BGL3 ST2A8_MOUSE Sult2a8 uc009fgc.1 uc009fgc.2 uc009fgc.3 uc009fgc.4 Hepatic sulfotransferase involved in the maintenance of bile acid homeostasis and energy balance. Catalyzes the transfer of sulfonate group from 3'-phosphoadenylyl sulfate (PAPS) to the 7-alpha hydroxy group of primary bile acids to form 7-monosulfate derivatives in the pathway of bile acid elimination. Displays high catalytic efficiency toward cholate, chenodeoxycholate and their glycine and taurine conjugates. Reaction=3'-phosphoadenylyl sulfate + cholate = adenosine 3',5'- bisphosphate + cholate 7-sulfate + H(+); Xref=Rhea:RHEA:67552, ChEBI:CHEBI:15378, ChEBI:CHEBI:29747, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:172392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67553; Evidence=; Reaction=3'-phosphoadenylyl sulfate + glycocholate = adenosine 3',5'- bisphosphate + glycocholate 7-sulfate + H(+); Xref=Rhea:RHEA:67556, ChEBI:CHEBI:15378, ChEBI:CHEBI:29746, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:172393; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67557; Evidence=; Reaction=3'-phosphoadenylyl sulfate + taurocholate = adenosine 3',5'- bisphosphate + H(+) + taurocholate 7-sulfate; Xref=Rhea:RHEA:67560, ChEBI:CHEBI:15378, ChEBI:CHEBI:36257, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:172394; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67561; Evidence=; Reaction=3'-phosphoadenylyl sulfate + chenodeoxycholate = adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+); Xref=Rhea:RHEA:67564, ChEBI:CHEBI:15378, ChEBI:CHEBI:36234, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:172395; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67565; Evidence=; Reaction=3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+); Xref=Rhea:RHEA:17689, ChEBI:CHEBI:15378, ChEBI:CHEBI:36252, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58877; EC=2.8.2.34; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17690; Evidence=; Reaction=3'-phosphoadenylyl sulfate + taurochenodeoxycholate = adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7- sulfate; Xref=Rhea:RHEA:67568, ChEBI:CHEBI:9407, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:172396; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67569; Evidence=; Reaction=3'-phosphoadenylyl sulfate + alpha-muricholate = adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+); Xref=Rhea:RHEA:67572, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:134116, ChEBI:CHEBI:172398; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67573; Evidence=; Kinetic parameters: KM=1.2 uM for cholate (at pH 6.27) ; KM=5.3 uM for glycocholate (at pH 6.27) ; KM=4.75 uM for chenodeoxycholate (at pH 6.27) ; KM=21.1 uM for taurocholate (at pH 6.27) ; KM=3.6 uM for taurochenodeoxycholate (at pH 6.27) ; Vmax=73.5 pmol/min/mg enzyme toward cholate (at pH 6.27) ; Vmax=82.7 pmol/min/mg enzyme glycocholate (at pH 6.27) ; Vmax=31.5 pmol/min/mg enzyme chenodeoxycholate (at pH 6.27) ; Vmax=100 pmol/min/mg enzyme taurocholate (at pH 6.27) ; Vmax=60.1 pmol/min/mg enzyme taurochenodeoxycholate (at pH 6.27) ; Note=The catalytic activity decreases as pH increases from 5.5 to 7.5. ; pH dependence: Optimum pH is 5.5. ; Lipid metabolism; bile acid degradation. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=L-STL1 ; IsoId=Q8BGL3-1; Sequence=Displayed; Name=2; Synonyms=L-STL2 ; IsoId=Q8BGL3-2; Sequence=VSP_061163; Liver (at protein level). Not detected in 8.5 and 14.5 dpc embryos. Expressed early in postnatal liver reaching maximal levels at one month of age in both male and female mice. The expression in female mice is lower than in males across the lifespan. Down-regulated by PPARA agonist Wy-14.643. The short isoform L-STL2 appears to be a minor form. It is likely non-functional as it lacks a conserved C-terminus region required for PAPS binding and sulfotransferase activity. Belongs to the sulfotransferase 1 family. molecular_function cellular_component sulfotransferase activity biological_process transferase activity uc009fgc.1 uc009fgc.2 uc009fgc.3 uc009fgc.4 
ENSMUST00000063517.6 Spats2 ENSMUST00000063517.6 spermatogenesis associated, serine-rich 2, transcript variant 1 (from RefSeq NM_139140.2) ENSMUST00000063517.1 ENSMUST00000063517.2 ENSMUST00000063517.3 ENSMUST00000063517.4 ENSMUST00000063517.5 NM_139140 Q3UX77 Q8C810 Q8K1N4 Q8R1P6 SPAS2_MOUSE Scr59 uc007xox.1 uc007xox.2 uc007xox.3 Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K1N4-1; Sequence=Displayed; Name=2; IsoId=Q8K1N4-2; Sequence=VSP_028790, VSP_028791; Detected in testis, in spermatocytes and round spermatids (at protein level). Highly expressed in testis, and detected at lower levels in brain, heart, thymus, skeletal muscle, ovary, stomach and lung. Detected in newborns. Levels increase during the first four weeks, and then remain at the same stable level. Belongs to the SPATS2 family. Sequence=AAH23432.1; Type=Erroneous initiation; Evidence=; cytoplasm cytosol biological_process uc007xox.1 uc007xox.2 uc007xox.3 
ENSMUST00000063520.15 Naa50 ENSMUST00000063520.15 N(alpha)-acetyltransferase 50, NatE catalytic subunit, transcript variant 1 (from RefSeq NM_028108.3) ENSMUST00000063520.1 ENSMUST00000063520.10 ENSMUST00000063520.11 ENSMUST00000063520.12 ENSMUST00000063520.13 ENSMUST00000063520.14 ENSMUST00000063520.2 ENSMUST00000063520.3 ENSMUST00000063520.4 ENSMUST00000063520.5 ENSMUST00000063520.6 ENSMUST00000063520.7 ENSMUST00000063520.8 ENSMUST00000063520.9 Mak3 NAA50_MOUSE NM_028108 Naa50 Nat13 Q3TH79 Q3TK59 Q6PGB6 Q7TML2 Q80VE3 Q9D0Q8 uc007zgy.1 uc007zgy.2 uc007zgy.3 N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (By similarity). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (By similarity). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (By similarity). Autoacetylates in vivo (By similarity). The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (By similarity). Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity (By similarity). Does not influence the acetyltransferase activity of NAA10 (By similarity). However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex) (By similarity). The multiprotein complexes probably constitute the major contributor for N- terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (By similarity). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 (By similarity). Reaction=acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]; Xref=Rhea:RHEA:50564, Rhea:RHEA-COMP:12726, Rhea:RHEA-COMP:12727, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133398, ChEBI:CHEBI:133399; EC=2.3.1.258; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]; Xref=Rhea:RHEA:50568, Rhea:RHEA-COMP:12728, Rhea:RHEA-COMP:12729, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133400, ChEBI:CHEBI:133401; EC=2.3.1.258; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]; Xref=Rhea:RHEA:50572, Rhea:RHEA-COMP:12730, Rhea:RHEA-COMP:12731, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133402, ChEBI:CHEBI:133403; EC=2.3.1.258; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]; Xref=Rhea:RHEA:50576, Rhea:RHEA-COMP:12732, Rhea:RHEA-COMP:12733, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133404, ChEBI:CHEBI:133405; EC=2.3.1.258; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]; Xref=Rhea:RHEA:50580, Rhea:RHEA-COMP:12734, Rhea:RHEA-COMP:12735, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133406, ChEBI:CHEBI:133407; EC=2.3.1.258; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]; Xref=Rhea:RHEA:50520, Rhea:RHEA-COMP:12711, Rhea:RHEA-COMP:12712, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133377, ChEBI:CHEBI:133378; EC=2.3.1.258; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl- [protein]; Xref=Rhea:RHEA:50528, Rhea:RHEA-COMP:12715, Rhea:RHEA- COMP:12716, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133382, ChEBI:CHEBI:133383; EC=2.3.1.258; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]; Xref=Rhea:RHEA:50532, Rhea:RHEA-COMP:12717, Rhea:RHEA-COMP:12718, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133384, ChEBI:CHEBI:133385; EC=2.3.1.258; Evidence=; Component of the N-terminal acetyltransferase E (NatE) complex at least composed of NAA10, NAA15 and NAA50 (By similarity). Interacts with NAA10 (By similarity). Interacts with NAA15 (By similarity). Predominantly interacts with NAA15 in the N-terminal acetyltransferase A complex (NatA complex); the interactions reduce the acetylation activity of the NatA complex (By similarity). Component of the N- terminal acetyltransferase E (NatE)/HYPK complex at least composed of NAA10, NAA15, NAA50 and HYPK (By similarity). Within the complex interacts with NAA15 (By similarity). Its capacity to interact with the NatA complex is reduced by HYPK (By similarity). Interacts with NAA35 (PubMed:16484612). Cytoplasm Nucleus Note=Localizes to the cytoplasm in interphase cells. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q6PGB6-1; Sequence=Displayed; Name=2; IsoId=Q6PGB6-2; Sequence=VSP_024749; Name=3; IsoId=Q6PGB6-3; Sequence=VSP_024750; Name=4; IsoId=Q6PGB6-4; Sequence=VSP_024748; Name=5; IsoId=Q6PGB6-5; Sequence=VSP_024749, VSP_024751; Belongs to the acetyltransferase family. GNAT subfamily. Sequence=BAE40319.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; peptide alpha-N-acetyltransferase activity protein binding nucleus cytoplasm cytosol N-terminal protein amino acid acetylation mitotic sister chromatid cohesion N-acetyltransferase activity H4 histone acetyltransferase activity histone acetylation transferase activity transferase activity, transferring acyl groups NatA complex establishment of mitotic sister chromatid cohesion histone H4 acetylation peptidyl-lysine acetyltransferase activity mitotic sister chromatid cohesion, centromeric uc007zgy.1 uc007zgy.2 uc007zgy.3 
ENSMUST00000063523.5 Prss58 ENSMUST00000063523.5 serine protease 58 (from RefSeq NM_175020.3) ENSMUST00000063523.1 ENSMUST00000063523.2 ENSMUST00000063523.3 ENSMUST00000063523.4 NM_175020 PRS58_MOUSE Q8BW11 Tryx3 uc009bnk.1 uc009bnk.2 uc009bnk.3 Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4; Secreted Belongs to the peptidase S1 family. Thr-195 is present instead of the conserved Ser which is expected to be an active site residue. It is therefore unsure if this protein has kept its catalytic activity. serine-type endopeptidase activity extracellular region proteolysis peptidase activity serine-type peptidase activity hydrolase activity secretory granule uc009bnk.1 uc009bnk.2 uc009bnk.3 
ENSMUST00000063524.3 5031410I06Rik ENSMUST00000063524.3 RIKEN cDNA 5031410I06 gene (from RefSeq NM_207657.3) 5031410I06Rik E9Q4E0 E9Q4E0_MOUSE ENSMUST00000063524.1 ENSMUST00000063524.2 NM_207657 uc008wtf.1 uc008wtf.2 uc008wtf.3 molecular_function cellular_component biological_process uc008wtf.1 uc008wtf.2 uc008wtf.3 
ENSMUST00000063551.7 Rgs7bp ENSMUST00000063551.7 regulator of G-protein signalling 7 binding protein (from RefSeq NM_029879.2) D13Bwg1146e ENSMUST00000063551.1 ENSMUST00000063551.2 ENSMUST00000063551.3 ENSMUST00000063551.4 ENSMUST00000063551.5 ENSMUST00000063551.6 NM_029879 Q0VF69 Q3UVC4 Q8BQP9 Q8CBD6 Q9CTP1 R7BP_MOUSE R7bp uc007rtp.1 uc007rtp.2 uc007rtp.3 Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. Interacts with 'R7' family proteins RGS6, RGS7, RGS9 and RGS11. Component of some R7-Gbeta5 complex composed of some R7 protein (RGS6, RGS7, RGS9 or RGS11), Gbeta5 (GNB5) and RGS7BP. Nucleus toplasm ll membrane ipid-anchor Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation (PubMed:15897264, PubMed:21343290). Specifically expressed in the central nervous system including the retina but not in other non-neuronal tissues (at protein level). The nuclear localization signal is both required for nuclear localization and palmitoylation. Palmitoylated (PubMed:15897264, PubMed:16574655, PubMed:21343290). Undergoes rapid palmitoylation turnover (PubMed:21343290). De novo and turnover palmitoylation are both mediated by ZDHHC2 (PubMed:21343290). Palmitoylation regulates the cell membrane and nuclear shuttling and the regulation of GPCR signaling (PubMed:15897264, PubMed:16574655, PubMed:16867977, PubMed:21343290). Upon depalmitoylation, it is targeted from the plasma membrane into the nucleus (PubMed:15897264, PubMed:16574655). GPCR signaling inhibits depalmitoylation and promotes localization to the plasma membrane (PubMed:21343290). Belongs to the RGS7BP/RGS9BP family. Sequence=BAC29358.1; Type=Frameshift; Evidence=; protein binding nucleus cytoplasm plasma membrane G-protein coupled receptor signaling pathway negative regulation of signal transduction membrane axon dendritic shaft perikaryon dendritic spine head regulation of postsynaptic membrane potential presynapse postsynapse glutamatergic synapse anchored component of presynaptic membrane anchored component of postsynaptic density membrane uc007rtp.1 uc007rtp.2 uc007rtp.3 
ENSMUST00000063562.9 Mipep ENSMUST00000063562.9 mitochondrial intermediate peptidase, transcript variant 1 (from RefSeq NM_027436.3) A6H611 ENSMUST00000063562.1 ENSMUST00000063562.2 ENSMUST00000063562.3 ENSMUST00000063562.4 ENSMUST00000063562.5 ENSMUST00000063562.6 ENSMUST00000063562.7 ENSMUST00000063562.8 MIPEP_MOUSE NM_027436 Q2YD79 Q3UJJ3 Q80VA3 uc288uzn.1 uc288uzn.2 Cleaves proteins, imported into the mitochondrion, to their mature size. Reaction=Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.; EC=3.4.24.59; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion. ; Activity is divalent cation-dependent. It is stimulated by manganese, magnesium or calcium ions and reversibly inhibited by zinc, cobalt and iron (By similarity). Monomer. Mitochondrion matrix Belongs to the peptidase M3 family. endopeptidase activity metalloendopeptidase activity mitochondrion mitochondrial matrix proteolysis peptide metabolic process protein processing involved in protein targeting to mitochondrion peptidase activity metallopeptidase activity hydrolase activity metal ion binding uc288uzn.1 uc288uzn.2 
ENSMUST00000063563.9 Nanos2 ENSMUST00000063563.9 nanos C2HC-type zinc finger 2 (from RefSeq NM_194064.2) ENSMUST00000063563.1 ENSMUST00000063563.2 ENSMUST00000063563.3 ENSMUST00000063563.4 ENSMUST00000063563.5 ENSMUST00000063563.6 ENSMUST00000063563.7 ENSMUST00000063563.8 F8VQ09 NANO2_MOUSE NM_194064 Nos2 P60322 uc009fjz.1 uc009fjz.2 uc009fjz.3 Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state. Interacts with CNOT1, CNOT3, CNOT6L, CNOT7 and CNOT9. P60322; Q6ZQ08: Cnot1; NbExp=3; IntAct=EBI-6507212, EBI-682479; Cytoplasm Cytoplasm, P-body Cytoplasm, perinuclear region Note=More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis (By similarity). Localizes at P-bodies during gonocyte development. Predominantly expressed in male germ cells. Expressed in self-renewing spermatogonial stem cells and developing gonads. First detectable at 13.5 dpc in the male gonocytes, levels increase until about 16.5 dpc and then slightly decrease by 17.5 dpc (at protein level). Expression is maintained in all male gonocytes during embryogenesis, but becomes confined to a small population of the spermatogonia after birth. The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein. Mice show a gradual loss of the germ cell population within a few cycles of spermatogenesis which is caused by the depletion of spermatogonial stem cells that produce differentiating spermatogenic cells. Belongs to the nanos family. P-body RNA binding mRNA binding protein binding nucleus cytoplasm mRNA catabolic process regulation of translation multicellular organism development spermatogenesis zinc ion binding negative regulation of translation cell differentiation germ-line stem cell population maintenance negative regulation of meiotic nuclear division metal ion binding perinuclear region of cytoplasm positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay uc009fjz.1 uc009fjz.2 uc009fjz.3 
ENSMUST00000063574.8 Tsr3 ENSMUST00000063574.8 TSR3 20S rRNA accumulation, transcript variant 1 (from RefSeq NM_026676.3) ENSMUST00000063574.1 ENSMUST00000063574.2 ENSMUST00000063574.3 ENSMUST00000063574.4 ENSMUST00000063574.5 ENSMUST00000063574.6 ENSMUST00000063574.7 NM_026676 Q5HZH2 Q9DD00 TSR3_MOUSE Tsr3 uc008baf.1 uc008baf.2 uc008baf.3 uc008baf.4 uc008baf.5 Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Reaction=N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl- L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3- carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'- thioadenosine; Xref=Rhea:RHEA:63292, Rhea:RHEA-COMP:11639, Rhea:RHEA- COMP:16308, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789, ChEBI:CHEBI:74890, ChEBI:CHEBI:146234; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63293; Evidence= Cytoplasm Belongs to the TDD superfamily. TSR3 family. cellular_component rRNA processing transferase activity maturation of SSU-rRNA ribosome biogenesis uc008baf.1 uc008baf.2 uc008baf.3 uc008baf.4 uc008baf.5 
ENSMUST00000063577.10 Zmym3 ENSMUST00000063577.10 zinc finger, MYM-type 3, transcript variant 1 (from RefSeq NM_019831.3) ENSMUST00000063577.1 ENSMUST00000063577.2 ENSMUST00000063577.3 ENSMUST00000063577.4 ENSMUST00000063577.5 ENSMUST00000063577.6 ENSMUST00000063577.7 ENSMUST00000063577.8 ENSMUST00000063577.9 Kiaa0385 NM_019831 Q80U17 Q9JLM4 ZMYM3_MOUSE Zfp261 Znf261 uc009txm.1 uc009txm.2 uc009txm.3 uc009txm.4 Plays a role in the regulation of cell morphology and cytoskeletal organization. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Q9JLM4; Q9UHL9: GTF2IRD1; Xeno; NbExp=3; IntAct=EBI-12517169, EBI-372530; Nucleus Ubiquitously expressed in all embryonic stages and adult tissues. Sequence=BAC65550.3; Type=Erroneous initiation; Evidence=; RNA polymerase II transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter cytoskeleton organization zinc ion binding regulation of cell morphogenesis metal ion binding uc009txm.1 uc009txm.2 uc009txm.3 uc009txm.4 
ENSMUST00000063578.6 Ghrhr ENSMUST00000063578.6 growth hormone releasing hormone receptor (from RefSeq NM_001003685.3) ENSMUST00000063578.1 ENSMUST00000063578.2 ENSMUST00000063578.3 ENSMUST00000063578.4 ENSMUST00000063578.5 GHRHR_MOUSE Grfr NM_001003685 P32082 Q0VB62 uc009cas.1 uc009cas.2 uc009cas.3 uc009cas.4 Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Cell membrane; Multi-pass membrane protein. Pituitary gland. Note=Little (lit) mice exhibits anterior pituitary hypoplasia. Belongs to the G-protein coupled receptor 2 family. transmembrane signaling receptor activity G-protein coupled receptor activity protein binding nuclear inner membrane nuclear outer membrane cytoplasm plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity lactation positive regulation of cell proliferation determination of adult lifespan G-protein coupled peptide receptor activity cell surface membrane integral component of membrane nuclear matrix growth hormone-releasing hormone receptor activity peptide hormone binding growth factor binding cAMP-mediated signaling adenohypophysis development water homeostasis secretory granule mammary gland development response to insulin cellular response to insulin stimulus regulation of intracellular steroid hormone receptor signaling pathway positive regulation of multicellular organism growth sarcolemma hormone metabolic process regulation of insulin-like growth factor receptor signaling pathway response to estrogen positive regulation of circadian sleep/wake cycle, non-REM sleep positive regulation of hormone secretion cell maturation regulation of protein metabolic process response to glucocorticoid positive regulation of growth hormone secretion somatotropin secreting cell development cellular response to glucose stimulus uc009cas.1 uc009cas.2 uc009cas.3 uc009cas.4 
ENSMUST00000063597.14 Casr ENSMUST00000063597.14 calcium-sensing receptor (from RefSeq NM_013803.3) CASR_MOUSE Casr ENSMUST00000063597.1 ENSMUST00000063597.10 ENSMUST00000063597.11 ENSMUST00000063597.12 ENSMUST00000063597.13 ENSMUST00000063597.2 ENSMUST00000063597.3 ENSMUST00000063597.4 ENSMUST00000063597.5 ENSMUST00000063597.6 ENSMUST00000063597.7 ENSMUST00000063597.8 ENSMUST00000063597.9 G3UX06 Gprc2a NM_013803 O08968 O88519 Q9QY95 Q9QY96 Q9QZU8 Q9R1D6 Q9R1Y2 uc007zcp.1 uc007zcp.2 uc007zcp.3 uc007zcp.4 G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (By similarity). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (PubMed:7493018). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (By similarity). In resting state, adopts an open conformation, anion-binding promoting the inactive configuration. Upon aromatic amino acid-binding, the groove in the extracellular venus flytrap module is closed, thereby inducing the formation of a novel homodimer interface between subunits. Calcium ions stabilize the active state by enhancing homodimer interactions between membrane-proximal domains to fully activate the receptor. Homodimer; disulfide-linked. Interacts with VCP and RNF19A (By similarity). Interacts with ARRB1 (By similarity). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=Q9QY96-1; Sequence=Displayed; Name=B; IsoId=Q9QY96-2; Sequence=VSP_002036; Epidermis, kidney and cartilage. The extracellular regions of the homodimer interact in a side- by-side fashion while facing opposite directions. Each extracellular region consists of three domains, LB1 (ligand-binding 1), LB2 and CR (cysteine-rich). The two lobe-shaped domains LB1 and LB2 form a venus flytrap module. In the inactive configuration, the venus flytrap modules of both protomers are in the open conformation associated with the resting state (open-open) and the interdomain cleft is empty. In addition, each protomer contains three anions, which reinforce the inactive conformation, and one calcium ion. In the active configuration, both protomers of extracellular regions have the closed conformation associated with agonist-binding (closed-closed). The ligand-binding cleft of each protomer is solely occupied by an aromatic amino-acid. Calcium is bound at four novel sites, including one at the homodimer interface. Agonist-binding induces large conformational changes within the extracellular region homodimer: first, the venus flytrap module of each protomer undergoes domain closure. Second, the LB2 regions of the two protomers approach each other, resulting in an expansion of the homodimer interactions involving LB2 domains. Third, the CR regions of the two subunits interact to form a large homodimer interface that is unique to the active state. The CR regions are brought into close contact by the motion involving LB2 since the two domains are rigidly associated within each subunit. N-glycosylated. Ubiquitinated by RNF19A; which induces proteasomal degradation. Heterozygous mice show benign and modest elevations of serum calcium, magnesium and parathyroid hormone levels as well as hypocalciuria. Homozygous mice show neonatal severe hyperparathyroidism, had markedly elevated serum calcium and parathyroid hormone levels, parathyroid hyperplasia, bone abnormalities, retarded growth and premature death. Belongs to the G-protein coupled receptor 3 family. ossification response to ischemia G-protein coupled receptor activity integrin binding calcium ion binding detection of calcium ion nucleus cytoplasm plasma membrane integral component of plasma membrane cellular calcium ion homeostasis apoptotic process signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway JNK cascade positive regulation of cell proliferation cell surface response to metal ion positive regulation of gene expression response to organic cyclic compound membrane integral component of membrane basolateral plasma membrane apical plasma membrane amino acid binding protein kinase binding axon positive regulation of insulin secretion positive regulation of ATPase activity bile acid secretion cellular response to hepatocyte growth factor stimulus signaling receptor activity vasodilation protein homodimerization activity neuron projection neuronal cell body axon terminus ion channel binding positive regulation of vasoconstriction metal ion binding branching morphogenesis of an epithelial tube positive regulation of positive chemotaxis response to calcium ion regulation of calcium ion transport fat pad development positive regulation of ERK1 and ERK2 cascade calcium ion import cellular response to vitamin D cellular response to glucose stimulus cellular response to low-density lipoprotein particle stimulus cellular response to hypoxia response to fibroblast growth factor positive regulation of calcium ion import cellular response to peptide chloride transmembrane transport uc007zcp.1 uc007zcp.2 uc007zcp.3 uc007zcp.4 
ENSMUST00000063605.15 Zbtb21 ENSMUST00000063605.15 zinc finger and BTB domain containing 21, transcript variant 2 (from RefSeq NM_001081684.2) E9Q3R9 E9Q3R9_MOUSE ENSMUST00000063605.1 ENSMUST00000063605.10 ENSMUST00000063605.11 ENSMUST00000063605.12 ENSMUST00000063605.13 ENSMUST00000063605.14 ENSMUST00000063605.2 ENSMUST00000063605.3 ENSMUST00000063605.4 ENSMUST00000063605.5 ENSMUST00000063605.6 ENSMUST00000063605.7 ENSMUST00000063605.8 ENSMUST00000063605.9 NM_001081684 Zbtb21 Zfp295 uc029szd.1 uc029szd.2 uc029szd.3 uc029szd.4 nucleic acid binding nucleus nucleoplasm cytosol methyl-CpG binding negative regulation of transcription, DNA-templated uc029szd.1 uc029szd.2 uc029szd.3 uc029szd.4 
ENSMUST00000063632.14 Sec31b ENSMUST00000063632.14 SEC31 homolog B, COPII coat complex component (from RefSeq NM_001033343.1) ENSMUST00000063632.1 ENSMUST00000063632.10 ENSMUST00000063632.11 ENSMUST00000063632.12 ENSMUST00000063632.13 ENSMUST00000063632.2 ENSMUST00000063632.3 ENSMUST00000063632.4 ENSMUST00000063632.5 ENSMUST00000063632.6 ENSMUST00000063632.7 ENSMUST00000063632.8 ENSMUST00000063632.9 Gm341 NM_001033343 Q3TZ89 Q811L4 SC31B_MOUSE Sec31l2 uc008hpu.1 uc008hpu.2 uc008hpu.3 As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum. COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with SEC31A (By similarity). Cytoplasm Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Endoplasmic reticulum membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TZ89-1; Sequence=Displayed; Name=2; IsoId=Q3TZ89-2; Sequence=VSP_026764; Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats. Belongs to the WD repeat SEC31 family. Golgi membrane structural molecule activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane intracellular protein transport ER to Golgi vesicle-mediated transport endoplasmic reticulum organization ER to Golgi transport vesicle membrane protein transport membrane vesicle-mediated transport vesicle coat COPII vesicle coat cytoplasmic vesicle endoplasmic reticulum exit site cargo loading into COPII-coated vesicle COPII-coated vesicle budding uc008hpu.1 uc008hpu.2 uc008hpu.3 
ENSMUST00000063635.15 Radil ENSMUST00000063635.15 Ras association and DIL domains, transcript variant 2 (from RefSeq NM_178702.4) ENSMUST00000063635.1 ENSMUST00000063635.10 ENSMUST00000063635.11 ENSMUST00000063635.12 ENSMUST00000063635.13 ENSMUST00000063635.14 ENSMUST00000063635.2 ENSMUST00000063635.3 ENSMUST00000063635.4 ENSMUST00000063635.5 ENSMUST00000063635.6 ENSMUST00000063635.7 ENSMUST00000063635.8 ENSMUST00000063635.9 Kiaa1849 NM_178702 Q69Z89 Q8BNL0 Q8C549 Q8C6X2 Q8CAL1 RADIL_MOUSE uc009ait.1 uc009ait.2 uc009ait.3 Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family. Interacts (via PDZ domain) with KIF14; is recruited to the microtubule network restricting its interaction with activated RAP1A (By similarity). Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q69Z89-1; Sequence=Displayed; Name=2; IsoId=Q69Z89-2; Sequence=VSP_016101, VSP_016103; Name=3; IsoId=Q69Z89-3; Sequence=VSP_016100; Name=4; IsoId=Q69Z89-4; Sequence=VSP_016101, VSP_016102; Name=5; IsoId=Q69Z89-5; Sequence=VSP_016101; Belongs to the RADIL family. Sequence=BAC38904.1; Type=Frameshift; Evidence=; Sequence=BAD32555.1; Type=Erroneous initiation; Evidence=; protein binding microtubule cell adhesion signal transduction multicellular organism development macromolecular complex substrate adhesion-dependent cell spreading uc009ait.1 uc009ait.2 uc009ait.3 
ENSMUST00000063641.11 Smim11 ENSMUST00000063641.11 small integral membrane protein 11 (from RefSeq NM_138743.2) ENSMUST00000063641.1 ENSMUST00000063641.10 ENSMUST00000063641.2 ENSMUST00000063641.3 ENSMUST00000063641.4 ENSMUST00000063641.5 ENSMUST00000063641.6 ENSMUST00000063641.7 ENSMUST00000063641.8 ENSMUST00000063641.9 Fam165b NM_138743 Q99J19 SIM11_MOUSE Smim11 Smim11a uc007zyx.1 uc007zyx.2 uc007zyx.3 Membrane ; Single-pass membrane protein Expressed in brain, heart, kidney, thymus, liver, stomach, muscle, lung, testis, ovary, skin and eye. molecular_function cellular_component biological_process membrane integral component of membrane uc007zyx.1 uc007zyx.2 uc007zyx.3 
ENSMUST00000063642.10 Ccdc30 ENSMUST00000063642.10 Ccdc30 (from geneSymbol) A0A589M9T4 A0A589M9T4_MOUSE AK078362 Ccdc30 ENSMUST00000063642.1 ENSMUST00000063642.2 ENSMUST00000063642.3 ENSMUST00000063642.4 ENSMUST00000063642.5 ENSMUST00000063642.6 ENSMUST00000063642.7 ENSMUST00000063642.8 ENSMUST00000063642.9 uc008umc.1 uc008umc.2 uc008umc.3 uc008umc.4 uc008umc.5 uc008umc.1 uc008umc.2 uc008umc.3 uc008umc.4 uc008umc.5 
ENSMUST00000063654.6 Btla ENSMUST00000063654.6 B and T lymphocyte associated, transcript variant 1 (from RefSeq NM_001037719.2) Btla E9QNY6 E9QNY6_MOUSE ENSMUST00000063654.1 ENSMUST00000063654.2 ENSMUST00000063654.3 ENSMUST00000063654.4 ENSMUST00000063654.5 NM_001037719 uc007zil.1 uc007zil.2 uc007zil.3 immune response-regulating cell surface receptor signaling pathway integral component of plasma membrane membrane integral component of membrane signaling receptor activity uc007zil.1 uc007zil.2 uc007zil.3 
ENSMUST00000063663.6 B3gat2 ENSMUST00000063663.6 beta-1,3-glucuronyltransferase 2 (from RefSeq NM_172124.2) B3GA2_MOUSE ENSMUST00000063663.1 ENSMUST00000063663.2 ENSMUST00000063663.3 ENSMUST00000063663.4 ENSMUST00000063663.5 Glcats NM_172124 P59270 uc007ame.1 uc007ame.2 uc007ame.3 uc007ame.4 Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Reaction=3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D- xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl- [protein] + H(+) + UDP; Xref=Rhea:RHEA:24168, Rhea:RHEA-COMP:12571, Rhea:RHEA-COMP:12573, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132090, ChEBI:CHEBI:132093; EC=2.4.1.135; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Protein modification; protein glycosylation. Homodimer. Golgi apparatus membrane ; Single- pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P59270-1; Sequence=Displayed; Name=2; IsoId=P59270-2; Sequence=VSP_001796, VSP_001797; Expressed in brain, but not in liver and kidney. Belongs to the glycosyltransferase 43 family. Golgi membrane Golgi apparatus protein glycosylation galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity membrane integral component of membrane carbohydrate biosynthetic process transferase activity metal ion binding chondroitin sulfate proteoglycan biosynthetic process uc007ame.1 uc007ame.2 uc007ame.3 uc007ame.4 
ENSMUST00000063669.8 Dhx32 ENSMUST00000063669.8 DEAH-box helicase 32 (putative), transcript variant 3 (from RefSeq NM_001286031.2) DHX32_MOUSE Ddx32 ENSMUST00000063669.1 ENSMUST00000063669.2 ENSMUST00000063669.3 ENSMUST00000063669.4 ENSMUST00000063669.5 ENSMUST00000063669.6 ENSMUST00000063669.7 NM_001286031 Q3TFU4 Q8BZS9 Q8VH39 Q922N6 uc009kdl.1 uc009kdl.2 uc009kdl.3 uc009kdl.4 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Nucleus Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZS9-1; Sequence=Displayed; Name=2; IsoId=Q8BZS9-2; Sequence=VSP_026428; Belongs to the DEAD box helicase family. DEAH subfamily. nucleotide binding RNA binding RNA helicase activity helicase activity ATP binding nucleus mitochondrion hydrolase activity uc009kdl.1 uc009kdl.2 uc009kdl.3 uc009kdl.4 
ENSMUST00000063682.12 Pfdn4 ENSMUST00000063682.12 prefoldin 4, transcript variant 1 (from RefSeq NM_001110152.3) ENSMUST00000063682.1 ENSMUST00000063682.10 ENSMUST00000063682.11 ENSMUST00000063682.2 ENSMUST00000063682.3 ENSMUST00000063682.4 ENSMUST00000063682.5 ENSMUST00000063682.6 ENSMUST00000063682.7 ENSMUST00000063682.8 ENSMUST00000063682.9 NM_001110152 Pfdn4 Q3UWL8 Q3UWL8_MOUSE uc008oce.1 uc008oce.2 uc008oce.3 uc008oce.4 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Belongs to the prefoldin subunit beta family. nucleus cytoplasm mitochondrion protein folding prefoldin complex unfolded protein binding uc008oce.1 uc008oce.2 uc008oce.3 uc008oce.4 
ENSMUST00000063683.8 Tagap1 ENSMUST00000063683.8 T cell activation GTPase activating protein 1 (from RefSeq NM_147155.2) ENSMUST00000063683.1 ENSMUST00000063683.2 ENSMUST00000063683.3 ENSMUST00000063683.4 ENSMUST00000063683.5 ENSMUST00000063683.6 ENSMUST00000063683.7 Fksg15 NM_147155 P0CAX8 Q8K2L9 TGAP1_MOUSE uc008aia.1 uc008aia.2 uc008aia.3 Previously thought to be the same gene as Tagap. These are distinct loci that encode proteins with identical C-termini but each with a unique N-terminus. GTPase activator activity cellular_component positive regulation of GTPase activity uc008aia.1 uc008aia.2 uc008aia.3 
ENSMUST00000063690.4 Dhrs9 ENSMUST00000063690.4 dehydrogenase/reductase 9 (from RefSeq NM_175512.2) DHRS9_MOUSE ENSMUST00000063690.1 ENSMUST00000063690.2 ENSMUST00000063690.3 NM_175512 Q58NB6 Q8BGC7 uc008jyb.1 uc008jyb.2 uc008jyb.3 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha- tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. Also plays a role in the biosynthesis of retinoic acid. Can utilize both NADH and NADPH. Reaction=3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) = 5alpha- pregnane-3,20-dione + H(+) + NADH; Xref=Rhea:RHEA:41988, ChEBI:CHEBI:11909, ChEBI:CHEBI:15378, ChEBI:CHEBI:28952, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha- androstan-3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:41992, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:16330, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=androsterone + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:20381, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:16032, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.209; Evidence=; Reaction=5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta- hydroxy-5alpha-androstan-3-one + H(+) + NADH; Xref=Rhea:RHEA:42004, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:36713, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.53; Evidence=; Reaction=all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH; Xref=Rhea:RHEA:21284, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.105; Evidence=; Reaction=3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) = 5alpha- pregnane-3,20-dione + H(+) + NADH; Xref=Rhea:RHEA:41980, ChEBI:CHEBI:15378, ChEBI:CHEBI:28952, ChEBI:CHEBI:50169, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Homotetramer. Microsome membrane Endoplasmic reticulum membrane Belongs to the short-chain dehydrogenases/reductases (SDR) family. retinoic acid biosynthetic process alcohol dehydrogenase (NAD) activity retinol dehydrogenase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid metabolic process androgen metabolic process membrane oxidoreductase activity integral component of endoplasmic reticulum membrane organelle membrane progesterone metabolic process 9-cis-retinoic acid biosynthetic process intracellular membrane-bounded organelle androsterone dehydrogenase activity testosterone dehydrogenase (NAD+) activity androstan-3-alpha,17-beta-diol dehydrogenase activity oxidation-reduction process uc008jyb.1 uc008jyb.2 uc008jyb.3 
ENSMUST00000063694.10 Klf13 ENSMUST00000063694.10 Kruppel-like transcription factor 13 (from RefSeq NM_021366.3) Bteb3 ENSMUST00000063694.1 ENSMUST00000063694.2 ENSMUST00000063694.3 ENSMUST00000063694.4 ENSMUST00000063694.5 ENSMUST00000063694.6 ENSMUST00000063694.7 ENSMUST00000063694.8 ENSMUST00000063694.9 Fklf2 KLF13_MOUSE NM_021366 Q9ESX3 Q9JHF8 Q9JJZ6 uc009hfn.1 uc009hfn.2 uc009hfn.3 Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage. Q9JJZ6; P70326: Tbx5; NbExp=3; IntAct=EBI-8407880, EBI-8411807; Nucleus. Ubiquitous. Belongs to the Sp1 C2H2-type zinc-finger protein family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter negative regulation of cell proliferation negative regulation of erythrocyte differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding uc009hfn.1 uc009hfn.2 uc009hfn.3 
ENSMUST00000063707.3 Stpg1 ENSMUST00000063707.3 sperm tail PG rich repeat containing 1, transcript variant 1 (from RefSeq NM_030189.4) ENSMUST00000063707.1 ENSMUST00000063707.2 NM_030189 Q9D2F5 STPG1_MOUSE uc008vgq.1 uc008vgq.2 May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine. Cytoplasm Nucleus After exposure to alkylating agent, significantly suppresses the depolarization of the mitochondrial membrane and the activation of BAK and caspase-3, all of which are hallmarks for the induction of apoptosis. Belongs to the STPG1 family. molecular_function nucleus cytoplasm mitochondrion apoptotic process positive regulation of apoptotic process positive regulation of protein homodimerization activity positive regulation of mitochondrial membrane permeability involved in apoptotic process uc008vgq.1 uc008vgq.2 
ENSMUST00000063726.5 Mageb6b1 ENSMUST00000063726.5 MAGE family member B6B1 (from RefSeq NM_001114678.1) A2AHM1 A2AHM1_MOUSE ENSMUST00000063726.1 ENSMUST00000063726.2 ENSMUST00000063726.3 ENSMUST00000063726.4 Gm5072 Gm8914 Mageb6b1 Mageb6b2 NM_001114678 uc057mbv.1 uc057mbv.2 molecular_function cellular_component biological_process uc057mbv.1 uc057mbv.2 
ENSMUST00000063750.8 Rarb ENSMUST00000063750.8 retinoic acid receptor, beta, transcript variant beta2 (from RefSeq NM_011243.2) ENSMUST00000063750.1 ENSMUST00000063750.2 ENSMUST00000063750.3 ENSMUST00000063750.4 ENSMUST00000063750.5 ENSMUST00000063750.6 ENSMUST00000063750.7 NM_011243 Q6DFX0 Q6DFX0_MOUSE Rarb uc007she.1 uc007she.2 uc007she.3 uc007she.4 uc007she.5 Nucleus Belongs to the nuclear hormone receptor family. NR1 subfamily. DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated drug binding zinc ion binding regulation of myelination steroid hormone mediated signaling pathway sequence-specific DNA binding macromolecular complex binding positive regulation of neuron differentiation metal ion binding retinoid X receptor binding retinoic acid receptor signaling pathway embryonic digestive tract development uc007she.1 uc007she.2 uc007she.3 uc007she.4 uc007she.5 
ENSMUST00000063761.8 Cpt1c ENSMUST00000063761.8 carnitine palmitoyltransferase 1c, transcript variant 1 (from RefSeq NM_153679.2) CPT1C_MOUSE ENSMUST00000063761.1 ENSMUST00000063761.2 ENSMUST00000063761.3 ENSMUST00000063761.4 ENSMUST00000063761.5 ENSMUST00000063761.6 ENSMUST00000063761.7 NM_153679 Q6NZF8 Q8BGD5 Q8C071 uc009gsb.1 uc009gsb.2 uc009gsb.3 uc009gsb.4 Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1 (By similarity). Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner (PubMed:32931550). Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control (PubMed:16651524, PubMed:22539351, PubMed:37309891). Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels (PubMed:12376098, PubMed:25751282, PubMed:30135643). Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; EC=3.1.2.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19234; Evidence=; Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including CPT1C. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (PubMed:32931550). Interacts with SACM1L; the interaction regulates SACM1L phosphatidylinositol-3- phosphatase activity and translocation to endoplasmic reticulum/trans Golgi network in a malonyl-CoA dependent manner (PubMed:32931550). Interacts with ATL1 (By similarity). Synapse Cell projection, axon Cell projection, dendrite Cell projection, dendritic spine Endoplasmic reticulum membrane ulti-pass membrane protein Note=Localized in the soma and dendritic and axonal projections. Predominantly expressed in brain (at protein level) and testis, highly expressed in the hippocampus, amygdala and cerebellum (PubMed:12376098, PubMed:22632720, PubMed:25751282, PubMed:37309891, PubMed:18192268, PubMed:22539351). Expressed in neurons but not astrocytes (PubMed:18192268, PubMed:25751282, PubMed:22539351). Expressed in the ventral horn from spinal cords (PubMed:25751282). CPT1 enzymes are comprised of an N-terminal regulatory domain and a C-terminal catalytic domain that are separated by two transmembrane helices. In CPT1A, the regulatory domain, termed N, adopts a malonyl-CoA inhibitory and non-inhibitory state, Nalpha and Nbeta, respectively, which differ in their association with the catalytic domain. In CPT1C, the inhibitory Nalpha state is structurally homolog whereas the non-inhibitory Nbeta state is severely destabilized which probably contributes to the low catalytic activity of CPT1C relative to CPT1A and makes its association with the catalytic domain unlikely. Knockout mice show decreased food intake but higher susceptibility to obesity and diabetes when fed a high fat diet (PubMed:16651524). Mutant mice show extensive learning and memory deficits, they exhibit impaired motor and instrumental learning as well as detrimental hippocampus-dependent spatial and habituation memory (PubMed:37309891). Belongs to the carnitine/choline acetyltransferase family. In contrast to its paralogs, CPT1A and CPT1B, does not have, or at very low levels, carnitine O-palmitoyltransferase activity (EC:2.3.1.21) in vivo, being unable to catalyze the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine. This is in agreement with its expression specific to neurons which is a cell-type that does not use fatty acids as fuel to any major extent and the fact that it locates to endoplasmic reticulum instead of mitochondria. carnitine O-palmitoyltransferase activity mitochondrion mitochondrial outer membrane endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation carnitine metabolic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups cell junction integral component of endoplasmic reticulum membrane axon dendrite AMPA glutamate receptor complex cell projection synapse postsynapse glutamatergic synapse regulation of postsynaptic specialization membrane neurotransmitter receptor levels uc009gsb.1 uc009gsb.2 uc009gsb.3 uc009gsb.4 
ENSMUST00000063771.14 Rgs14 ENSMUST00000063771.14 regulator of G-protein signaling 14, transcript variant 1 (from RefSeq NM_016758.3) ENSMUST00000063771.1 ENSMUST00000063771.10 ENSMUST00000063771.11 ENSMUST00000063771.12 ENSMUST00000063771.13 ENSMUST00000063771.2 ENSMUST00000063771.3 ENSMUST00000063771.4 ENSMUST00000063771.5 ENSMUST00000063771.6 ENSMUST00000063771.7 ENSMUST00000063771.8 ENSMUST00000063771.9 NM_016758 P97492 Q8K2R4 Q9DCD1 RGS14_MOUSE uc007qqq.1 uc007qqq.2 uc007qqq.3 Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)- stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division; required for completion of the first mitotic division of the embryo. Involved in visual memory processing capacity; when overexpressed in the V2 secondary visual cortex area. Involved in hippocampal-based learning and memory; acts as a suppressor of synaptic plasticity in CA2 neurons. Required for the nerve growth factor (NGF)- mediated neurite outgrowth. Involved in stress resistance. Interacts with GNAI1 and GNAI2 (PubMed:15112653, PubMed:17635935). Interacts with GNAI3 (By similarity). Interacts with GNAO1 (PubMed:10926822). Interacts (via RGS and GoLoco domains) with GNAI1; the interaction occurs in the centrosomes. Interaction with GNAI1 or GNAI3 (via active GTP- or inactive GDP-bound forms) prevents association of RGS14 with centrosomes or nuclear localization (By similarity). Interacts with RABGEF1; the interactions is GTP-dependent (PubMed:10926822, PubMed:15112653). Interacts with RAP2A; the interactions is GTP-dependent and does not alter its function on G(i) alpha subunits either as GAP or as GDI (PubMed:10926822, PubMed:15112653). Associates with microtubules (By similarity). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14. Interacts with RIC8A (via C-terminus). Interacts (via RBD 1 domain) with HRAS (active GTP-bound form preferentially). Interacts (via RBD domains) with BRAF (via N-terminus); the interaction mediates the formation of a ternary complex with RAF1. Interacts (via RBD domains) with RAF1 (via N-terminus); the interaction mediates the formation of a ternary complex with BRAF. Interacts with KRAS (active GTP-bound form preferentially), MRAS (active GTP-bound form preferentially), NRAS (active GTP-bound form preferentially) and RRAS (active GTP-bound form preferentially) (By similarity). Nucleus. Nucleus, PML body. Cytoplasm. Membrane. Cell membrane Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, dendrite. Cell projection, dendritic spine. Postsynaptic density. Note=Localizes with spindle poles during metaphase. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Recruited from the cytosol to the plasma membrane by the inactive GDP-bound forms of G(i) alpha subunits GNAI1 and GNAI3. Recruited from the cytosol to membranes by the active GTP-bound form of HRAS. Colocalizes with G(i) alpha subunit GNAI1 and RIC8A at the plasma membrane. Colocalizes with BRAF and RAF1 in both the cytoplasm and membranes (By similarity). Associates with the perinuclear sheaths of microtubules (MTs) surrounding the pronuclei, prior to segregating to the anastral mitotic apparatus and subsequently the barrel- shaped cytoplasmic bridge between the nascent nuclei of the emerging 2-cell embryo. Localizes to a perinuclear compartment near the microtubule-organizing center (MTOC). Expressed in the nucleus during interphase and segregates to the centrosomes and astral MTs during mitosis. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Relocalizes to the nucleus in PML nuclear bodies in respons to heat stress. Colocalizes with RIC8A in CA2 hippocampal neurons. Expressed in pyramidal neurons of the CA1, CA2 and fasciola cinerea (FC) subregions of the hippocampus and in the olfactory cortex (at protein level). Expressed in brain, spleen, heart, liver, lung, kidney, skin and thymus (at protein level). Expressed in granular layer of the cerebellum, forbrain, striatum, layer V of the cortex, olfactory cortex, tubercules, subthalamic and hippocampus, particularly in the CA2 region, to a lesser extent in the CA1 region and the external layer of the dentate gyrus. Expressed in neurons. Expressed in germinal vesicle oocytes, not in metaphase II oocytes. Expressed in embryo from 8.5 through 16.5 dpc (at protein level). Expressed in the zygote through to the blastocyst stage. Expressed in area lateral to the rhombencephalic floor plate at 12 dpc. Expressed in the anterior region of the brain, including the telencephalic olfactive nuclei and the hippocampus anlage at 17 dpc. The RGS domain is necessary for GTPase-activating protein (GAP) activity for G subunits and localization to the nucleus and centrosomes. The GoLoco domain is necessary for GDP-dissociation inhibitor (GDI) activity, translocation out of the nucleus and interaction with G(i) alpha subunits GNAI1, GNAI2 and GNAI3. The RBD domains are necessary for localization to the nucleus and centrosomes. Phosphorylated by PKC. Phosphorylation is increased in presence of forskolin and may enhance the GDI activity on G(i) alpha subunit GNAI1 (By similarity). No visible phenotype. Mice show an enhancement of postsynaptic long-term potentiation (LTP) responses in the CA2 neurons of the hippocampus that is correlated with an increase of spatial learning and object recognition memory (OMR). Name=Protein Spotlight; Note=A balanced mind - Issue 132 of October 2011; URL="https://web.expasy.org/spotlight/back_issues/132"; mitotic cell cycle spindle pole G-protein alpha-subunit binding GDP-dissociation inhibitor activity GTPase activator activity protein binding nucleus cytoplasm centrosome microtubule organizing center spindle cytoskeleton microtubule plasma membrane nucleocytoplasmic transport response to oxidative stress cell cycle spindle organization chromosome segregation signal transduction G-protein coupled receptor signaling pathway multicellular organism development learning long-term memory microtubule binding regulation of G-protein coupled receptor protein signaling pathway visual learning positive regulation of signal transduction negative regulation of signal transduction zygote asymmetric cell division postsynaptic density membrane nuclear body PML body protein kinase binding cell junction receptor signaling complex scaffold activity dendrite GTPase regulator activity negative regulation of synaptic plasticity GTPase activating protein binding intracellular signal transduction cell projection dendritic spine negative regulation of MAP kinase activity positive regulation of GTPase activity regulation of DNA-templated transcription in response to stress synapse postsynaptic membrane negative regulation of G-protein coupled receptor protein signaling pathway platelet-derived growth factor receptor signaling pathway positive regulation of neurogenesis modulation of synaptic transmission cell division long-term synaptic potentiation negative regulation of ERK1 and ERK2 cascade glutamatergic synapse uc007qqq.1 uc007qqq.2 uc007qqq.3 
ENSMUST00000063775.5 Ldlrad4 ENSMUST00000063775.5 low density lipoprotein receptor class A domain containing 4, transcript variant 1 (from RefSeq NM_172631.4) D18Ertd653e ENSMUST00000063775.1 ENSMUST00000063775.2 ENSMUST00000063775.3 ENSMUST00000063775.4 LRAD4_MOUSE NM_172631 Q8BWJ4 uc008fng.1 uc008fng.2 uc008fng.3 Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. Interacts with PMEPA1. Interacts (via the SMAD interaction motif) with SMAD2 and SMAD3 (By similarity). Early endosome membrane ; Single- pass membrane protein Detected in all tissues tested. The SMAD interaction motif is required for interaction with SMAD2 and SMAD3 and the negative regulation of TGF-beta signaling. Belongs to the PMEPA1 family. nucleoplasm endosome negative regulation of signal transduction negative regulation of epithelial to mesenchymal transition negative regulation of SMAD protein complex assembly membrane integral component of membrane negative regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway early endosome membrane intracellular membrane-bounded organelle negative regulation of pathway-restricted SMAD protein phosphorylation R-SMAD binding uc008fng.1 uc008fng.2 uc008fng.3 
ENSMUST00000063814.15 Gnpda1 ENSMUST00000063814.15 glucosamine-6-phosphate deaminase 1 (from RefSeq NM_011937.2) ENSMUST00000063814.1 ENSMUST00000063814.10 ENSMUST00000063814.11 ENSMUST00000063814.12 ENSMUST00000063814.13 ENSMUST00000063814.14 ENSMUST00000063814.2 ENSMUST00000063814.3 ENSMUST00000063814.4 ENSMUST00000063814.5 ENSMUST00000063814.6 ENSMUST00000063814.7 ENSMUST00000063814.8 ENSMUST00000063814.9 GNPI1_MOUSE Gnpi NM_011937 O88958 Q91WJ4 Q9R188 uc008esi.1 uc008esi.2 uc008esi.3 uc008esi.4 Catalyzes the reversible conversion of alpha-D-glucosamine 6- phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling (By similarity). Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity). Reaction=alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6- phosphate + NH4(+); Xref=Rhea:RHEA:12172, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57634, ChEBI:CHEBI:75989; EC=3.5.99.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12173; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:12174; Evidence=; Allosterically activated by N-acetylglucosamine-6- phosphate (GlcNAc6P). Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D- fructose 6-phosphate: step 1/1. Homohexamer. Cytoplasm Widely expressed. Detected in brain, liver, kidney, muscle, ovary, testis, spermatids and spermatozoa. In spermatids, located close to the developing acrosome vesicle. In spermatozoa, found close to the acrosomal region. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. glucosamine-6-phosphate deaminase activity cytoplasm carbohydrate metabolic process fructose 6-phosphate metabolic process glucosamine metabolic process glucosamine catabolic process N-acetylglucosamine metabolic process N-acetylglucosamine catabolic process UDP-N-acetylglucosamine biosynthetic process generation of precursor metabolites and energy acrosome reaction hydrolase activity N-acetylneuraminate catabolic process identical protein binding fructose biosynthetic process uc008esi.1 uc008esi.2 uc008esi.3 uc008esi.4 
ENSMUST00000063816.6 D630039A03Rik ENSMUST00000063816.6 RIKEN cDNA D630039A03 gene (from RefSeq NM_178727.2) D630039A03Rik ENSMUST00000063816.1 ENSMUST00000063816.2 ENSMUST00000063816.3 ENSMUST00000063816.4 ENSMUST00000063816.5 NM_178727 Q8BHF6 Q8K0M7 Q8K0M7_MOUSE uc008syo.1 uc008syo.2 uc008syo.3 molecular_function cellular_component biological_process uc008syo.1 uc008syo.2 uc008syo.3 
ENSMUST00000063820.12 F10 ENSMUST00000063820.12 coagulation factor X, transcript variant 2 (from RefSeq NM_007972.4) ENSMUST00000063820.1 ENSMUST00000063820.10 ENSMUST00000063820.11 ENSMUST00000063820.2 ENSMUST00000063820.3 ENSMUST00000063820.4 ENSMUST00000063820.5 ENSMUST00000063820.6 ENSMUST00000063820.7 ENSMUST00000063820.8 ENSMUST00000063820.9 F10 NM_007972 Q3TBR2 Q3TBR2_MOUSE uc009kws.1 uc009kws.2 uc009kws.3 This gene encodes factor X, a component of both the intrinsic and extrinsic blood coagulation pathways. The encoded protein is a zymogen that undergoes further processing in a vitamin K-dependent manner to generate mature factor X, a heterodimer comprised of disulfide-linked heavy and light chains. The mature factor X is proteolytically activated either by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway) to form factor Xa serine endopeptidase. Activated factor Xa catalyzes the conversion of prothrombin to thrombin. A complete lack of the encoded protein is fatal to mice. A severe deficiency of the encoded protein in mice causes age-dependent iron deposition and cardiac fibrosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]. Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Reaction=Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.; EC=3.4.21.6; Evidence=; The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds. Forms a heterodimer with SERPINA5. Secreted Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase activity calcium ion binding extracellular region proteolysis blood coagulation peptidase activity serine-type peptidase activity hydrolase activity uc009kws.1 uc009kws.2 uc009kws.3 
ENSMUST00000063824.14 Rasal3 ENSMUST00000063824.14 RAS protein activator like 3, transcript variant 7 (from RefSeq NR_174480.1) A3KMM0 ENSMUST00000063824.1 ENSMUST00000063824.10 ENSMUST00000063824.11 ENSMUST00000063824.12 ENSMUST00000063824.13 ENSMUST00000063824.2 ENSMUST00000063824.3 ENSMUST00000063824.4 ENSMUST00000063824.5 ENSMUST00000063824.6 ENSMUST00000063824.7 ENSMUST00000063824.8 ENSMUST00000063824.9 NR_174480 Q8C2A5 Q8C2K5 Q8C9R4 Q8CDB4 RASL3_MOUSE uc008bwv.1 uc008bwv.2 uc008bwv.3 Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down- stream ERK signaling pathway. Cytoplasm Cytoplasm, cell cortex Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C2K5-1; Sequence=Displayed; Name=2; IsoId=Q8C2K5-2; Sequence=VSP_031931, VSP_031932; Predominantly expressed in hematopoietic tissues. No visible phenotype. The number of natural killer T (NKT) cells in the liver is selectively decreased (around 50%) in mutant mice (PubMed:25652366). It is uncertain whether Met-1 or Met-23 is the initiator. Sequence=BAC30956.1; Type=Frameshift; Evidence=; GTPase activator activity cytoplasm cell cortex signal transduction regulation of GTPase activity positive regulation of GTPase activity negative regulation of Ras protein signal transduction positive regulation of NK T cell proliferation cytoplasmic side of membrane uc008bwv.1 uc008bwv.2 uc008bwv.3 
ENSMUST00000063838.11 Cyrib ENSMUST00000063838.11 CYFIP related Rac1 interactor B, transcript variant 2 (from RefSeq NM_144846.5) CYRIB_MOUSE Cyri ENSMUST00000063838.1 ENSMUST00000063838.10 ENSMUST00000063838.2 ENSMUST00000063838.3 ENSMUST00000063838.4 ENSMUST00000063838.5 ENSMUST00000063838.6 ENSMUST00000063838.7 ENSMUST00000063838.8 ENSMUST00000063838.9 Fam49b NM_144846 Q921M7 uc007vzf.1 uc007vzf.2 uc007vzf.3 uc007vzf.4 Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (By similarity). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (PubMed:31285585). Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164). Interacts with RAC1 (GTP-bound form preferentially). Membrane ; Lipid- anchor Mitochondrion Expressed in pancreatic ducts (at protein level). Ubiquitinated at Lys-74 upon Salmonella bacterial infection. Myeloid-specific conditional knockout mice have a reduced survival following Salmonella systemic infection. Upon infection, they show increased levels of several serum pro-inflammatory cytokines and chemokines produced by activated neutrophils and monocytes. Belongs to the CYRI family. positive regulation of T cell mediated cytotoxicity protein binding cilium membrane MHC class Ib protein binding, via antigen binding groove positive regulation of interferon-gamma production positive regulation of T cell activation positive regulation of memory T cell activation uc007vzf.1 uc007vzf.2 uc007vzf.3 uc007vzf.4 
ENSMUST00000063839.6 Rbm12b2 ENSMUST00000063839.6 RNA binding motif protein 12 B2, transcript variant 1 (from RefSeq NM_198957.2) A2AJP4 ENSMUST00000063839.1 ENSMUST00000063839.2 ENSMUST00000063839.3 ENSMUST00000063839.4 ENSMUST00000063839.5 NM_198957 Q3TE05 Q66JV4 Q8BNP2 Q8K0T9 R12BB_MOUSE Rbm12bb uc008sak.1 uc008sak.2 uc008sak.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q66JV4-1; Sequence=Displayed; Name=2; IsoId=Q66JV4-2; Sequence=VSP_022525; Sequence=AAH30408.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleic acid binding RNA binding cellular_component biological_process uc008sak.1 uc008sak.2 uc008sak.3 
ENSMUST00000063854.7 Ppp4r2 ENSMUST00000063854.7 protein phosphatase 4, regulatory subunit 2, transcript variant 1 (from RefSeq NM_182939.5) A0A0R4J0U2 A0A0R4J0U2_MOUSE ENSMUST00000063854.1 ENSMUST00000063854.2 ENSMUST00000063854.3 ENSMUST00000063854.4 ENSMUST00000063854.5 ENSMUST00000063854.6 NM_182939 Ppp4r2 uc009dcb.1 uc009dcb.2 uc009dcb.3 Belongs to the PPP4R2 family. protein phosphatase regulator activity protein phosphatase 4 complex regulation of phosphoprotein phosphatase activity uc009dcb.1 uc009dcb.2 uc009dcb.3 
ENSMUST00000063857.11 Slc6a9 ENSMUST00000063857.11 Sodium- and chloride-dependent glycine transporter which is essential for regulating glycine concentrations at inhibitory glycinergic synapses. (from UniProt P28571) AK048168 B1ASI9 ENSMUST00000063857.1 ENSMUST00000063857.10 ENSMUST00000063857.2 ENSMUST00000063857.3 ENSMUST00000063857.4 ENSMUST00000063857.5 ENSMUST00000063857.6 ENSMUST00000063857.7 ENSMUST00000063857.8 ENSMUST00000063857.9 Glyt1 P28571 Q8VC47 SC6A9_MOUSE uc290peo.1 uc290peo.2 Sodium- and chloride-dependent glycine transporter which is essential for regulating glycine concentrations at inhibitory glycinergic synapses. [Isoform GlyT-1A]: Sodium- and chloride-dependent glycine transporter. Reaction=chloride(out) + glycine(out) + 2 Na(+)(out) = chloride(in) + glycine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70691, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57305; Evidence=; [Isoform GlyT-1A]: Reaction=chloride(out) + glycine(out) + 2 Na(+)(out) = chloride(in) + glycine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70691, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57305; Evidence=; [Isoform GlyT-1A]: Kinetic parameters: KM=20 uM for glycine ; Interacts with EXOC1; interaction increases the transporter capacity of SLC6A9 probably by promoting its insertion into the cell membrane (By similarity). Interacts with EXOC3 and EXOC4 (By similarity). Cell membrane ; Multi-pass membrane protein Event=Alternative promoter usage, Alternative splicing; Named isoforms=3; Name=GlyT-1C; Synonyms=GLYT1c; IsoId=P28571-3; Sequence=Displayed; Name=GlyT-1A; Synonyms=GLYT1a; IsoId=P28571-1; Sequence=VSP_006272; Name=GlyT-1B; Synonyms=GLYT1b; IsoId=P28571-2; Sequence=VSP_039241; Expressed in the brain (at protein level) (PubMed:27773429). At 11 dpc, expressed in the ventral part of the ventricular zone. At 15 dpc, also expressed in adjacent mantle tissue and the meninges. Strongly expressed in 12 dpc and 15 dpc liver. [Isoform GlyT-1A]: Expressed in the brain. Expression is present at low levels as early as 9 dpc and 10 dpc, but strongly increases at 13 dpc and remains at high levels up to 15 dpc. Also expressed in adult. Mice show severe motor and respiration deficits at birth and die during the first postnatal day (PubMed:14622582). Accumulation of glycine in the synaptic cleft results in over- activation of postsynaptic glycine receptors and death of the newborn animals due to respiratory and feeding problem (PubMed:14622582). [Isoform GlyT-1C]: Produced by alternative promoter usage. [Isoform GlyT-1A]: Produced by alternative promoter usage. [Isoform GlyT-1B]: Produced by alternative splicing of isoform GlyT-1C. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily. neurotransmitter uptake amino acid transmembrane transport sodium:amino acid symporter activity neurotransmitter:sodium symporter activity plasma membrane integral component of plasma membrane neurotransmitter transport amino acid transport postsynaptic density glycine transmembrane transporter activity symporter activity glycine transport membrane integral component of membrane integral component of synaptic vesicle membrane asymmetric synapse transmembrane transport glycine secretion, neurotransmission integral component of postsynaptic membrane integral component of presynaptic membrane organic acid transmembrane transport uc290peo.1 uc290peo.2 
ENSMUST00000063871.13 Cbln3 ENSMUST00000063871.13 cerebellin 3 precursor protein (from RefSeq NM_019820.3) CBLN3_MOUSE ENSMUST00000063871.1 ENSMUST00000063871.10 ENSMUST00000063871.11 ENSMUST00000063871.12 ENSMUST00000063871.2 ENSMUST00000063871.3 ENSMUST00000063871.4 ENSMUST00000063871.5 ENSMUST00000063871.6 ENSMUST00000063871.7 ENSMUST00000063871.8 ENSMUST00000063871.9 NM_019820 Q9JHG0 uc007uba.1 uc007uba.2 uc007uba.3 May be involved in synaptic functions in the CNS. Heterohexamer; disulfide-linked heterotrimers (By similarity). Interacts with CBLN1. May also form oligomers with CBLN2 and CBLN4. Endoplasmic reticulum. Golgi apparatus, cis-Golgi network. Secreted. Synapse. Note=In the absence of CBLN1, remains in the endoplasmic reticulum/cis-Golgi apparatus. Partial secretion depends on an association with CBLN1 and maybe CBLN4, but not on CBLN2. Expressed in brain, restricted to the cerebellar cortex. Within the cerebellum, expressed in granule layers (at protein level). Also detected in postsynaptic Purkinje cell spines (at protein level). In the developing brain, selectively expressed as early as postnatal day 7-10 in cerebellar granule cells. protein binding extracellular region extracellular space endoplasmic reticulum Golgi apparatus biological_process cell junction synapse uc007uba.1 uc007uba.2 uc007uba.3 
ENSMUST00000063879.13 Plpp2 ENSMUST00000063879.13 phospholipid phosphatase 2, transcript variant 1 (from RefSeq NM_015817.3) ENSMUST00000063879.1 ENSMUST00000063879.10 ENSMUST00000063879.11 ENSMUST00000063879.12 ENSMUST00000063879.2 ENSMUST00000063879.3 ENSMUST00000063879.4 ENSMUST00000063879.5 ENSMUST00000063879.6 ENSMUST00000063879.7 ENSMUST00000063879.8 ENSMUST00000063879.9 Lpp2 NM_015817 PLPP2_MOUSE Plpp2 Ppap2c Q9DAX2 Q9WUA4 uc007fyr.1 uc007fyr.2 uc007fyr.3 uc007fyr.4 The protein encoded by this gene is a lipid phosphate phosphohydrolase. It is an integral membrane protein that catalyzes the conversion of phosphatidic acid to diacylglycerol and inorganic phosphate. The transcript is expressed at high levels in lung, liver, and kidney and at low levels in brain and heart. Null mutant mice are viable and fertile and display no overt phenotypic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly. Also acts on N-oleoyl ethanolamine phosphate/N- (9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (By similarity). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn- glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27430; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2- dihexadecanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:43236, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:72859, ChEBI:CHEBI:82929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43237; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2- di-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:43244, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43245; Evidence=; Reaction=H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate; Xref=Rhea:RHEA:46736, ChEBI:CHEBI:15377, ChEBI:CHEBI:17408, ChEBI:CHEBI:43474, ChEBI:CHEBI:77589; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46737; Evidence=; Reaction=(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z- octadecenoyl)-glycerol + phosphate; Xref=Rhea:RHEA:50884, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:75937, ChEBI:CHEBI:84973; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50885; Evidence=; Reaction=H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine; Xref=Rhea:RHEA:27518, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27519; Evidence=; Reaction=an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4- enine + phosphate; Xref=Rhea:RHEA:33743, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52639, ChEBI:CHEBI:57674; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33744; Evidence=; Reaction=H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N- octanoylsphing-4-enine + phosphate; Xref=Rhea:RHEA:62040, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:45815, ChEBI:CHEBI:85376; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62041; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z- octadecenoyl) ethanolamine + phosphate; Xref=Rhea:RHEA:62160, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:71466, ChEBI:CHEBI:145465; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62161; Evidence=; Magnesium-independent phospholipid phosphatase. Insensitive to N-ethylmaleimide. Lipid metabolism; phospholipid metabolism. Forms functional homodimers and homooligomers. Can also form heterooligomers with PLPP1 and PLPP3. Membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DAX2-1; Sequence=Displayed; Name=2; IsoId=Q9DAX2-2; Sequence=VSP_009654, VSP_009655; Expressed at high levels in lung, liver and kidney; at low levels in heart and brain, and was not detected in skeletal muscle. N-glycosylated. Mice lacking Plpp2 do not show overt phenotype (PubMed:10992322). Born at the expected Mendelian frequency they are perfectly viable and fertile (PubMed:10992322). Belongs to the PA-phosphatase related phosphoesterase family. integral component of plasma membrane phospholipid metabolic process phosphatidate phosphatase activity membrane integral component of membrane hydrolase activity phosphatase activity lipid phosphatase activity phospholipid dephosphorylation uc007fyr.1 uc007fyr.2 uc007fyr.3 uc007fyr.4 
ENSMUST00000063882.12 Dcun1d4 ENSMUST00000063882.12 defective in cullin neddylation 1 domain containing 4, transcript variant J (from RefSeq NR_189592.1) DCNL4_MOUSE Dcun1d4 ENSMUST00000063882.1 ENSMUST00000063882.10 ENSMUST00000063882.11 ENSMUST00000063882.2 ENSMUST00000063882.3 ENSMUST00000063882.4 ENSMUST00000063882.5 ENSMUST00000063882.6 ENSMUST00000063882.7 ENSMUST00000063882.8 ENSMUST00000063882.9 NR_189592 Q2YDW5 Q8CCA0 SCCRO4 uc008xsz.1 uc008xsz.2 uc008xsz.3 uc008xsz.4 Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). Interacts (via the DCUN1 domain) with the unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5; these interactions promote the cullin neddylation and the identity of the cullin dictates the affinity of the interaction. Interacts with RBX1 and RNF7. Interacts with CAND1; this interaction is bridged by cullins such as CUL3 and strongly inhibits the neddylation of CUL3. These CAND- cullin-DCNL complexes can only be neddylated in the presence of a substrate adapter. Interacts (via DCUN1 domain) with UBE2M (N- terminally acetylated form) and probably with UBE2F (N-terminally acetylated form). Nucleus Highest levels of expression are in the testis (PubMed:26792857). Very low levels of expression in other tissues such as the heart, brain, kidney, liver, lung and ovary (PubMed:26792857). The DCUN1 domain, also known as PONY domain, mediates the interaction with different cullins. The DCUN1 domain mediates the interaction with the N-terminally acetylated NEDD8-conjugating E2s enzyme leading to the NEDD8 transfer from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes; the neddylation efficiency correlates with the DCUN1D5- cullin and DCUN1D5-E2 interaction affinities. ubiquitin ligase complex molecular_function cellular_component nucleus biological_process ubiquitin conjugating enzyme binding ubiquitin-like protein binding protein neddylation positive regulation of ubiquitin-protein transferase activity cullin family protein binding uc008xsz.1 uc008xsz.2 uc008xsz.3 uc008xsz.4 
ENSMUST00000063886.4 Acvr2a ENSMUST00000063886.4 activin receptor IIA (from RefSeq NM_007396.4) AVR2A_MOUSE Acvr2 Acvr2a ENSMUST00000063886.1 ENSMUST00000063886.2 ENSMUST00000063886.3 NM_007396 P27038 uc008jpn.1 uc008jpn.2 uc008jpn.3 uc008jpn.4 On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555). Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA- COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44881; Evidence=; Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18674; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Part of a complex consisting of MAGI2/ARIP1, ACVR2A, ACVR1B and SMAD3 (PubMed:10681527). Interacts with MAGI2/ARIP1 (PubMed:10681527). Interacts with type I receptor ACVR1 (By similarity). Interacts with BMP7 (By similarity). Interacts with TSC22D1/TSC-22 (By similarity). P27038; P12643: BMP2; Xeno; NbExp=2; IntAct=EBI-1036102, EBI-1029262; Cell membrane ; Single-pass type I membrane protein Brain, testis, intestine, liver and kidney. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. nucleotide binding gastrulation with mouth forming second positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type II protein binding ATP binding cytoplasm plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway spermatogenesis determination of left/right symmetry pattern specification process mesoderm development male gonad development anterior/posterior pattern specification regulation of signal transduction cell surface positive regulation of pathway-restricted SMAD protein phosphorylation coreceptor activity membrane integral component of membrane kinase activity phosphorylation transferase activity activin-activated receptor activity growth factor binding PDZ domain binding positive regulation of bone mineralization BMP signaling pathway activin receptor signaling pathway positive regulation of activin receptor signaling pathway inhibin-betaglycan-ActRII complex inhibin binding type I transforming growth factor beta receptor binding sperm ejaculation penile erection receptor complex protein self-association positive regulation of erythrocyte differentiation positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter SMAD binding metal ion binding positive regulation of follicle-stimulating hormone secretion activin receptor complex activin binding embryonic skeletal system development regulation of nitric-oxide synthase activity Sertoli cell proliferation cellular response to BMP stimulus BMP receptor activity uc008jpn.1 uc008jpn.2 uc008jpn.3 uc008jpn.4 
ENSMUST00000063888.5 Pld4 ENSMUST00000063888.5 phospholipase D family member 4 (from RefSeq NM_178911.4) ENSMUST00000063888.1 ENSMUST00000063888.2 ENSMUST00000063888.3 ENSMUST00000063888.4 NM_178911 PLD4_MOUSE Q3TD59 Q3UA19 Q6PDR0 Q8BG07 Q8BR69 uc007pfc.1 uc007pfc.2 uc007pfc.3 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (PubMed:30111894). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor (PubMed:30111894). Involved in phagocytosis of activated microglia (PubMed:22102906). Reaction=Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates.; EC=3.1.16.1; Evidence=; pH dependence: Optimum pH is pH 5.5-5. ; Endoplasmic reticulum membrane ; Single-pass type II membrane protein Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein Nucleus Early endosome Cytoplasmic vesicle, phagosome Note=Activation of microglia induces translocation of PLD4 from the nucleus to the phagosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BG07-1; Sequence=Displayed; Name=2; IsoId=Q8BG07-2; Sequence=VSP_023630; Enriched in the white matter of early postnatal brains, as well as in splenic marginal zone cells (PubMed:21085684). Highly expressed in dendritic cells (DCs) and other myeloid cells, with lower expression in B cell (PubMed:30111894). First detected in cerebellum at postnatal day 0 (P0), increased with age and peaked at P7, and then rapidly decreased to adult levels by P21. Up-regulated by lipopolysaccharide (LPS) stimulation in microglia (PubMed:22102906). Increased expression in activated microglia and in the demyelinating lesions of adult brain (PubMed:22102906). Highly N-glycosylated. Deficient mice exhibit a phenotype of chronic activation of the immune system, with splenomegaly marked by elevated levels of interferon-gamma (IFN-gamma) (PubMed:30111894). PDL3 and PLD4 double-deficient mice are unable to survive beyond the age of 21 days due to severe liver inflammation (PubMed:30111894). Livers from double- knockout mice develop lethal hepatic autoinflammatory disease that could be prevented by a single allele of either PDL3 or PLD4 (PubMed:30111894). Belongs to the phospholipase D family. Exhibits no phospholipase activity, despite two HKD motifs. Sequence=BAC32379.1; Type=Frameshift; Evidence=; hematopoietic progenitor cell differentiation catalytic activity protein binding nucleus endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phagocytosis membrane integral component of membrane lipid catabolic process hydrolase activity trans-Golgi network membrane phagocytic vesicle N-acylphosphatidylethanolamine-specific phospholipase D activity phospholipase D activity uc007pfc.1 uc007pfc.2 uc007pfc.3 
ENSMUST00000063918.4 Sp8 ENSMUST00000063918.4 trans-acting transcription factor 8, transcript variant 2 (from RefSeq NM_177082.4) ENSMUST00000063918.1 ENSMUST00000063918.2 ENSMUST00000063918.3 NM_177082 Q8BMJ8 Q8BWA3 SP8_MOUSE uc007pih.1 uc007pih.2 uc007pih.3 uc007pih.4 Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos. Nucleus Expression is detected in the forebrain, midbrain/hindbrain boundary and neural tube. At the stage of limb bud outgrowth, expressed in a scattered manner in the ventral ectoderm, and is later confined to the apical ectodermal ridge (AER). The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Belongs to the Sp1 C2H2-type zinc-finger protein family. RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleic acid binding DNA binding nucleus regulation of transcription from RNA polymerase II promoter dorsal/ventral pattern formation proximal/distal pattern formation embryonic limb morphogenesis metal ion binding uc007pih.1 uc007pih.2 uc007pih.3 uc007pih.4 
ENSMUST00000063920.3 Art2b ENSMUST00000063920.3 ADP-ribosyltransferase 2b (from RefSeq NM_019915.3) ENSMUST00000063920.1 ENSMUST00000063920.2 F8VQK8 NAR2B_MOUSE NM_019915 O35702 O35975 Rt6-2 Rt6.2 uc009ioy.1 uc009ioy.2 Has both NAD(+) glycohydrolase and ADP-ribosyltransferase activity. Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D- ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=2.4.2.31; Evidence=; Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.5; Evidence=; Cell membrane ; Lipid-anchor, GPI- anchor Expressed in spleen, intestine and thymus. Belongs to the Arg-specific ADP-ribosyltransferase family. NAD+ ADP-ribosyltransferase activity NAD(P)+-protein-arginine ADP-ribosyltransferase activity plasma membrane protein ADP-ribosylation membrane transferase activity transferase activity, transferring glycosyl groups hydrolase activity hydrolase activity, acting on glycosyl bonds peptidyl-arginine ADP-ribosylation NAD catabolic process extrinsic component of plasma membrane anchored component of membrane anchored component of external side of plasma membrane anchored component of plasma membrane NAD glycohydrolase activity uc009ioy.1 uc009ioy.2 
ENSMUST00000063956.7 Cd177 ENSMUST00000063956.7 CD177 antigen (from RefSeq NM_026862.4) CD177_MOUSE ENSMUST00000063956.1 ENSMUST00000063956.2 ENSMUST00000063956.3 ENSMUST00000063956.4 ENSMUST00000063956.5 ENSMUST00000063956.6 NM_026862 Q8R2S8 uc009fql.1 uc009fql.2 In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (By similarity). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (By similarity). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (By similarity). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:25359465). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (By similarity). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (By similarity). Found in a complex with integrin ITGAM/CD11b and ITGB2/CD18. Interacts with PECAM1 (via Ig-like C2-type domain 6); the interaction is Ca(2+)-dependent; the interaction is direct. Interacts with serine protease PRTN3/myeloblastin; the interaction tethers PRTN3 to the cell surface; the interaction is direct. Cell membrane ; Single-pass type IV membrane protein Expressed in neutrophils. Mice are viable, fertile and are born at the expected Mendelian rate. Slight decrease in blood CD11b(+)Ly-6G(-)Ly- 6C(+) monocyte and CD11b(+)Ly-6G(+)Ly-6C(+) neutrophil populations. Lymphocyte and myeloid development is not affected. In S.aureus- mediated skin infection, recruitment of neutrophils and monocytes to the infection site is transiently reduced. In thioglycolate-induced peritonitis, recruitment of neutrophils is normal. protease binding immune system process integrin binding plasma membrane cell adhesion leukocyte cell-cell adhesion membrane integral component of membrane regulation of endocytosis secretory granule membrane positive regulation of superoxide anion generation protein localization to cell surface positive regulation of neutrophil degranulation plasma membrane raft innate immune response cell-cell junction maintenance calcium-dependent protein binding tertiary granule membrane neutrophil extravasation cell-cell adhesion via plasma-membrane adhesion molecules regulation of integrin-mediated signaling pathway uc009fql.1 uc009fql.2 
ENSMUST00000063957.6 Hbb-bh1 ENSMUST00000063957.6 hemoglobin Z, beta-like embryonic chain (from RefSeq NM_008219.3) ENSMUST00000063957.1 ENSMUST00000063957.2 ENSMUST00000063957.3 ENSMUST00000063957.4 ENSMUST00000063957.5 Glnb3 Hbb-bh1 NM_008219 Q5EBL1 Q5EBL1_MOUSE uc009iur.1 uc009iur.2 uc009iur.3 Belongs to the globin family. oxygen transporter activity hemoglobin complex oxygen transport oxygen binding heme binding hemoglobin alpha binding metal ion binding protein heterooligomerization uc009iur.1 uc009iur.2 uc009iur.3 
ENSMUST00000063976.9 Opa3 ENSMUST00000063976.9 optic atrophy 3 (from RefSeq NM_207525.3) ENSMUST00000063976.1 ENSMUST00000063976.2 ENSMUST00000063976.3 ENSMUST00000063976.4 ENSMUST00000063976.5 ENSMUST00000063976.6 ENSMUST00000063976.7 ENSMUST00000063976.8 NM_207525 OPA3_MOUSE Q505D7 Q8C6Z9 uc009flc.1 uc009flc.2 uc009flc.3 May play some role in mitochondrial processes. Mitochondrion Belongs to the OPA3 family. molecular_function mitochondrion visual perception regulation of lipid metabolic process regulation of growth neuromuscular process mitochondrion morphogenesis uc009flc.1 uc009flc.2 uc009flc.3 
ENSMUST00000063977.9 Ppp1r36 ENSMUST00000063977.9 protein phosphatase 1, regulatory subunit 36 (from RefSeq NM_001163103.1) D3Z0R2 ENSMUST00000063977.1 ENSMUST00000063977.2 ENSMUST00000063977.3 ENSMUST00000063977.4 ENSMUST00000063977.5 ENSMUST00000063977.6 ENSMUST00000063977.7 ENSMUST00000063977.8 Gm70 NM_001163103 PPR36_MOUSE uc011yob.1 uc011yob.2 uc011yob.3 Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Interacts with PPP1CA. protein phosphatase inhibitor activity cellular_component negative regulation of phosphatase activity phosphatase binding negative regulation of phosphoprotein phosphatase activity uc011yob.1 uc011yob.2 uc011yob.3 
ENSMUST00000063980.8 Zkscan7 ENSMUST00000063980.8 zinc finger with KRAB and SCAN domains 7 (from RefSeq NM_001177505.2) E9PVW1 E9PVW1_MOUSE ENSMUST00000063980.1 ENSMUST00000063980.2 ENSMUST00000063980.3 ENSMUST00000063980.4 ENSMUST00000063980.5 ENSMUST00000063980.6 ENSMUST00000063980.7 NM_001177505 Zfp167 Zkscan7 uc009sfh.1 uc009sfh.2 uc009sfh.3 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding transcription factor activity, sequence-specific DNA binding cellular_component nucleus regulation of transcription, DNA-templated biological_process metal ion binding uc009sfh.1 uc009sfh.2 uc009sfh.3 
ENSMUST00000063982.7 Fzd5 ENSMUST00000063982.7 frizzled class receptor 5, transcript variant 1 (from RefSeq NM_022721.4) ENSMUST00000063982.1 ENSMUST00000063982.2 ENSMUST00000063982.3 ENSMUST00000063982.4 ENSMUST00000063982.5 ENSMUST00000063982.6 FZD5_MOUSE G5E8F0 NM_022721 O08975 Q8BMR2 Q8CHK9 Q9EQD0 uc007bgy.1 uc007bgy.2 uc007bgy.3 Receptor for Wnt proteins (PubMed:11092808, PubMed:18230341). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (PubMed:11092808). In neurons, activation of WNT7A promotes formation of synapses (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:18230341). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:18230341). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (PubMed:11092808). Binding of unsaturated fatty acid molecules (via FZ domain) promotes homodimerization (via FZ domain). Interacts with WNT2B (By similarity). Interacts with WNT7A (PubMed:18230341, PubMed:20530549). Interacts with GOPC (PubMed:11520064). Q9EQD0; Q8BH60: Gopc; NbExp=3; IntAct=EBI-7938232, EBI-296357; Cell membrane ulti-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Synapse Perikaryon Cell projection, dendrite Cell projection, axon Note=Localized at the plasma membrane and also found at the Golgi. Detected in hippocampus (at protein level) (PubMed:20530549). Expressed in eye, kidney, lung, chondrocytes, epithelial cells of the small intestine and gobelet cells of the colon (PubMed:8626800). Detected at low levels in neonate brain; expression levels increase steadily during the first four weeks after birth and show a further increase in adults (at protein level) (PubMed:20530549). Expressed in the yolk sac, placenta, eye and lung bud at 9.5 dpc. At 10.5 dpc, also expressed in the placental blood vessel of embryonic origin (PubMed:11092808). The PDZ-binding motif mediates interaction with GOPC. The FZ domain is involved in binding with Wnt ligands. Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome. Full embryonic lethality around 12.5 dpc, due to defects in yolk sac and placenta vascularization. Belongs to the G-protein coupled receptor Fz/Smo family. Sequence=AAG39355.1; Type=Frameshift; Evidence=; Golgi membrane embryonic axis specification angiogenesis beta-amyloid binding vasculature development positive regulation of T cell cytokine production transmembrane signaling receptor activity G-protein coupled receptor activity protein binding Golgi apparatus plasma membrane integral component of plasma membrane bicellular tight junction signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway multicellular organism development negative regulation of cell proliferation lipid binding anterior/posterior axis specification, embryo cell surface membrane integral component of membrane Wnt signaling pathway Wnt-protein binding protein kinase binding cell junction cell differentiation axon dendrite embryonic camera-type eye development post-embryonic camera-type eye development ubiquitin protein ligase binding positive regulation of interferon-gamma production T cell differentiation in thymus non-canonical Wnt signaling pathway Wnt-activated receptor activity cell projection perikaryon positive regulation of JUN kinase activity macromolecular complex binding synapse positive regulation of transcription from RNA polymerase II promoter cell maturation perinuclear region of cytoplasm embryonic camera-type eye morphogenesis positive regulation of interleukin-1 beta secretion Spemann organizer formation canonical Wnt signaling pathway apoptotic process involved in morphogenesis branching involved in labyrinthine layer morphogenesis syncytiotrophoblast cell differentiation involved in labyrinthine layer development labyrinthine layer blood vessel development chorionic trophoblast cell differentiation cellular response to molecule of bacterial origin glutamatergic synapse presynapse assembly regulation of chorionic trophoblast cell proliferation positive regulation of tumor necrosis factor secretion regulation of bicellular tight junction assembly early endosome uc007bgy.1 uc007bgy.2 uc007bgy.3 
ENSMUST00000064016.6 Gpr17 ENSMUST00000064016.6 G protein-coupled receptor 17 (from RefSeq NM_001025381.2) ENSMUST00000064016.1 ENSMUST00000064016.2 ENSMUST00000064016.3 ENSMUST00000064016.4 ENSMUST00000064016.5 GPR17_MOUSE Gpr17 NM_001025381 Q6NS65 Q80UD2 uc008eiw.1 uc008eiw.2 uc008eiw.3 uc008eiw.4 Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia (By similarity). Q6NS65; Q99JA4: Cysltr1; NbExp=2; IntAct=EBI-15791369, EBI-15791392; Cell membrane; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. negative regulation of inflammatory response to antigenic stimulus G-protein coupled receptor activity protein binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane receptor serine/threonine kinase binding positive regulation of Rho protein signal transduction oligodendrocyte differentiation positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway uc008eiw.1 uc008eiw.2 uc008eiw.3 uc008eiw.4 
ENSMUST00000064054.14 Syt1 ENSMUST00000064054.14 synaptotagmin I, transcript variant 2 (from RefSeq NM_009306.3) ENSMUST00000064054.1 ENSMUST00000064054.10 ENSMUST00000064054.11 ENSMUST00000064054.12 ENSMUST00000064054.13 ENSMUST00000064054.2 ENSMUST00000064054.3 ENSMUST00000064054.4 ENSMUST00000064054.5 ENSMUST00000064054.6 ENSMUST00000064054.7 ENSMUST00000064054.8 ENSMUST00000064054.9 NM_009306 P46096 SYT1_MOUSE Syt1 uc007gzg.1 uc007gzg.2 uc007gzg.3 uc007gzg.4 Calcium sensor that participates in triggering neurotransmitter release at the synapse (PubMed:11242035). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (PubMed:7961887). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (By similarity). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. ; Homotetramer (Probable). Heterodimer; heterodimerizes with SYT2 in presence of calcium (By similarity). Interacts with SCAMP5 (By similarity). Interacts with STON2 (By similarity). Forms a complex with SV2B, syntaxin 1 and SNAP25 (PubMed:15466855). Interacts with SV2A, SV2B and SV2C (By similarity). Interacts with RIMS1 (By similarity). Interacts with PRRT2 (PubMed:27052163). Interacts with DNAJC5 in a phosphorylation-dependent manner (By similarity). Interacts (via N- terminus) with RAB3A (By similarity). Interacts with SYT12 (By similarity). Interacts with calmodulin (By similarity). Interacts with DNM1 (via C-terminal proline-rich domain (PRD)); this interaction facilitates vesicle fission during clathrin-mediated endocytosis (CME) (By similarity). P46096; P49769: Psen1; NbExp=6; IntAct=EBI-445340, EBI-990067; P46096; Q8TAC9: SCAMP5; Xeno; NbExp=2; IntAct=EBI-445340, EBI-2695784; Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane ; Single-pass membrane protein Cytoplasm Expressed in the brain and adrenal medulla (at protein level). Detected in the brain at 18 days post coitum (dpc) (at protein level). Expression increases after birth, with expression increasing till adulthood. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with SV2A and probably with STN2. Glycosylated. Belongs to the synaptotagmin family. SNARE binding phosphatidylserine binding calcium ion binding detection of calcium ion protein binding calmodulin binding phospholipid binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm Golgi apparatus plasma membrane neurotransmitter secretion brain development synaptic vesicle protein C-terminus binding regulation of dopamine secretion membrane integral component of membrane synaptic vesicle exocytosis vesicle-mediated transport syntaxin-1 binding calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis syntaxin binding cell junction secretory granule cell differentiation clathrin binding integral component of synaptic vesicle membrane syntaxin-3 binding axon synaptic vesicle membrane dense core granule positive regulation of vesicle fusion cytoplasmic vesicle chromaffin granule membrane presynaptic membrane identical protein binding neuron projection intracellular organelle neuron projection terminus synapse positive regulation of calcium ion-dependent exocytosis metal ion binding protein heterodimerization activity vesicle docking calcium-dependent protein binding synaptic vesicle endocytosis calcium ion-regulated exocytosis of neurotransmitter low-density lipoprotein particle receptor binding positive regulation of synaptic transmission protein homooligomerization protein heterooligomerization response to calcium ion regulation of synaptic transmission, glutamatergic excitatory synapse spontaneous neurotransmitter secretion exocytic vesicle cellular response to calcium ion synchronous neurotransmitter secretion fast, calcium ion-dependent exocytosis of neurotransmitter glutamatergic synapse calcium-dependent activation of synaptic vesicle fusion positive regulation of calcium ion-dependent exocytosis of neurotransmitter regulation of regulated secretory pathway positive regulation of dendrite extension regulation of synaptic vesicle exocytosis SNARE complex uc007gzg.1 uc007gzg.2 uc007gzg.3 uc007gzg.4 
ENSMUST00000064061.4 Scrt2 ENSMUST00000064061.4 scratch family zinc finger 2 (from RefSeq NM_001160410.2) A2AQU7 ENSMUST00000064061.1 ENSMUST00000064061.2 ENSMUST00000064061.3 NM_001160410 Q8BTH6 SCRT2_MOUSE uc012cgb.1 uc012cgb.2 May be involved in transcriptional regulation. Nucleus Belongs to the snail C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding regulation of neuron migration uc012cgb.1 uc012cgb.2 
ENSMUST00000064068.5 Fpr2 ENSMUST00000064068.5 formyl peptide receptor 2 (from RefSeq NM_008039.2) ENSMUST00000064068.1 ENSMUST00000064068.2 ENSMUST00000064068.3 ENSMUST00000064068.4 FPR2_MOUSE Fpr-rs2 NM_008039 O88536 uc033hbc.1 uc033hbc.2 uc033hbc.3 High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophil chemotactic factors (PubMed:12218158, PubMed:10477558, PubMed:19387439). Stimulates chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation (PubMed:10477558, PubMed:19497865). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (PubMed:29138422). Interacts with Amyloid-beta protein 42, product of APP; the interaction takes place at the cell surface and the complex is then rapidly internalized. Cell membrane ; Multi-pass membrane protein Note=Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized. Primarily expressed in neutrophils. Not detected in vomeronasal neurons. Blocks Fam19a5-stimulated macrophage chemotaxis and phosphorylation of Erk1 and Akt1 (PubMed:29138422). Suppression of Fam19a5-mediated inhibition of Rankl-induced osteoclast differentiation (PubMed:29138422). Belongs to the G-protein coupled receptor 1 family. beta-amyloid binding microglial cell activation positive regulation of protein phosphorylation complement receptor mediated signaling pathway immune response-regulating cell surface receptor signaling pathway G-protein coupled receptor activity N-formyl peptide receptor activity scavenger receptor binding cytoplasm plasma membrane receptor-mediated endocytosis chemotaxis inflammatory response signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane calcium-mediated signaling positive regulation of superoxide anion generation signaling receptor activity cargo receptor activity defense response to bacterium positive regulation of innate immune response positive regulation of G-protein coupled receptor protein signaling pathway astrocyte activation negative regulation of inflammatory response positive regulation of phagocytosis RAGE receptor binding positive chemotaxis positive regulation of ERK1 and ERK2 cascade positive regulation of monocyte chemotaxis cellular response to beta-amyloid uc033hbc.1 uc033hbc.2 uc033hbc.3 
ENSMUST00000064076.6 Tnni3k ENSMUST00000064076.6 TNNI3 interacting kinase (from RefSeq NM_177066.5) B2RTJ7 Cark ENSMUST00000064076.1 ENSMUST00000064076.2 ENSMUST00000064076.3 ENSMUST00000064076.4 ENSMUST00000064076.5 NM_177066 Q5GIG5 Q5GIG6 TNI3K_MOUSE Tnni3k uc008rus.1 uc008rus.2 uc008rus.3 uc008rus.4 May play a role in cardiac physiology. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, FABP3 and HADHB. Nucleus Cytoplasm Note=Expressed at lower levels in the cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5GIG6-1; Sequence=Displayed; Name=2; IsoId=Q5GIG6-2; Sequence=VSP_051886, VSP_051887; Autophosphorylated. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. nucleotide binding regulation of heart rate protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation protein C-terminus binding kinase activity phosphorylation transferase activity troponin I binding metal ion binding regulation of cardiac muscle contraction bundle of His cell to Purkinje myocyte communication regulation of cardiac conduction uc008rus.1 uc008rus.2 uc008rus.3 uc008rus.4 
ENSMUST00000064091.12 Ptpn4 ENSMUST00000064091.12 protein tyrosine phosphatase, non-receptor type 4 (from RefSeq NM_019933.2) ENSMUST00000064091.1 ENSMUST00000064091.10 ENSMUST00000064091.11 ENSMUST00000064091.2 ENSMUST00000064091.3 ENSMUST00000064091.4 ENSMUST00000064091.5 ENSMUST00000064091.6 ENSMUST00000064091.7 ENSMUST00000064091.8 ENSMUST00000064091.9 G5E8E7 NM_019933 PTN4_MOUSE Q9WU22 uc007ciz.1 uc007ciz.2 uc007ciz.3 uc007ciz.4 Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:17953619, PubMed:25825441). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (By similarity). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441). Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (PubMed:18614237). May act at junctions between the membrane and the cytoskeleton. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Q9WU22; P24161: Cd247; NbExp=3; IntAct=EBI-7249866, EBI-7803400; Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Highly expressed in testis. Specifically expressed in spermatocytes and spermatids within seminiferous tubules (at protein level). PTPN4-deficient mice are born at normal Mendelian ratio with no apparent developmental or phenotypic defects. They display normal cytokine production and T-cell effector functions (PubMed:18614237). However, they show impairment in motor learning and cerebellar long-term depression (PubMed:17953619). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity protein binding cytoplasm cytoskeleton plasma membrane protein dephosphorylation cytoskeletal protein binding cytoplasmic side of plasma membrane membrane dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc007ciz.1 uc007ciz.2 uc007ciz.3 uc007ciz.4 
ENSMUST00000064099.8 Ppp6r1 ENSMUST00000064099.8 protein phosphatase 6, regulatory subunit 1 (from RefSeq NM_172894.2) ENSMUST00000064099.1 ENSMUST00000064099.2 ENSMUST00000064099.3 ENSMUST00000064099.4 ENSMUST00000064099.5 ENSMUST00000064099.6 ENSMUST00000064099.7 Kiaa1115 NM_172894 PP6R1_MOUSE Pp6r1 Q7TSI3 Q80TJ4 Saps1 uc009eyb.1 uc009eyb.2 uc009eyb.3 Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha (By similarity). Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed of the catalytic subunit, a SAPS domain- containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28, ANKRD44 and ANKRD52 (By similarity). Cytoplasm Ubiquitous with highest expression in lung, spleen and bladder. Belongs to the SAPS family. Sequence=BAC65732.3; Type=Miscellaneous discrepancy; Note=Derived from pre-RNA.; Evidence=; cytoplasm cytosol Rho GTPase binding protein phosphatase binding regulation of phosphoprotein phosphatase activity uc009eyb.1 uc009eyb.2 uc009eyb.3 
ENSMUST00000064104.13 Cdc42se2 ENSMUST00000064104.13 CDC42 small effector 2 (from RefSeq NM_178626.3) C42S2_MOUSE ENSMUST00000064104.1 ENSMUST00000064104.10 ENSMUST00000064104.11 ENSMUST00000064104.12 ENSMUST00000064104.2 ENSMUST00000064104.3 ENSMUST00000064104.4 ENSMUST00000064104.5 ENSMUST00000064104.6 ENSMUST00000064104.7 ENSMUST00000064104.8 ENSMUST00000064104.9 NM_178626 Q3UKN9 Q8BGH7 uc007iyf.1 uc007iyf.2 uc007iyf.3 uc007iyf.4 Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T- cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity). Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA (By similarity). Cytoplasm, cytoskeleton Cell membrane ; Lipid-anchor Cell projection, phagocytic cup Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages. Detected in spleen, thymus and lung (at protein level). The CRIB domain mediates interaction with CDC42. Belongs to the CDC42SE/SPEC family. phagocytic cup cytoplasm cytoskeleton plasma membrane phagocytosis regulation of cell shape regulation of signal transduction positive regulation of signal transduction membrane Rho GTPase binding regulation of Rho protein signal transduction signaling adaptor activity cell projection uc007iyf.1 uc007iyf.2 uc007iyf.3 uc007iyf.4 
ENSMUST00000064107.7 Tbc1d30 ENSMUST00000064107.7 TBC1 domain family, member 30, transcript variant 1 (from RefSeq NM_029057.2) B9EHP9 ENSMUST00000064107.1 ENSMUST00000064107.2 ENSMUST00000064107.3 ENSMUST00000064107.4 ENSMUST00000064107.5 ENSMUST00000064107.6 Kiaa0984 NM_029057 Q69ZT9 Q6AXF5 Q6PCX1 Q8C8T3 TBC30_MOUSE uc007hfm.1 uc007hfm.2 uc007hfm.3 uc007hfm.4 uc007hfm.5 GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro (By similarity). Cell membrane ; Peripheral membrane protein Sequence=AAH79587.1; Type=Frameshift; Evidence=; Sequence=BAD32357.1; Type=Erroneous initiation; Evidence=; GTPase activator activity cytosol plasma membrane cilium intracellular protein transport membrane Rab GTPase binding ciliary basal body positive regulation of GTPase activity activation of GTPase activity negative regulation of cilium assembly uc007hfm.1 uc007hfm.2 uc007hfm.3 uc007hfm.4 uc007hfm.5 
ENSMUST00000064110.14 Doc2a ENSMUST00000064110.14 double C2, alpha, transcript variant 8 (from RefSeq NR_178188.1) DOC2A_MOUSE ENSMUST00000064110.1 ENSMUST00000064110.10 ENSMUST00000064110.11 ENSMUST00000064110.12 ENSMUST00000064110.13 ENSMUST00000064110.2 ENSMUST00000064110.3 ENSMUST00000064110.4 ENSMUST00000064110.5 ENSMUST00000064110.6 ENSMUST00000064110.7 ENSMUST00000064110.8 ENSMUST00000064110.9 NR_178188 Q7TNF0 uc009jtb.1 uc009jtb.2 Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts (via N-terminus) with UNC13A. Interacts with cytoplasmic dynein light chain DYNLT1 (By similarity). Interacts with UNC13D (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein Synapse, synaptosome Lysosome Brain and mast cells. C2 domain 1 is involved in binding calcium and phospholipids. calcium ion binding calcium-dependent phospholipid binding nucleus nucleolus lysosome exocytosis chemical synaptic transmission membrane synaptic vesicle exocytosis regulation of calcium ion-dependent exocytosis cell junction synaptic vesicle membrane cytoplasmic vesicle neuron projection synapse spontaneous neurotransmitter secretion extrinsic component of synaptic vesicle membrane uc009jtb.1 uc009jtb.2 
ENSMUST00000064139.8 Plpp3 ENSMUST00000064139.8 phospholipid phosphatase 3 (from RefSeq NM_080555.2) ENSMUST00000064139.1 ENSMUST00000064139.2 ENSMUST00000064139.3 ENSMUST00000064139.4 ENSMUST00000064139.5 ENSMUST00000064139.6 ENSMUST00000064139.7 Lpp3 NM_080555 PLPP3_MOUSE Plpp3 Ppap2b Q3TVM4 Q3TXR7 Q8BTB7 Q99JY8 uc008tye.1 uc008tye.2 uc008tye.3 Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z- octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro- inflammatory cytokines (By similarity). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (PubMed:21319224). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (By similarity). Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta- catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth (PubMed:12925589, PubMed:27125875). Also plays a role in integrin- mediated cell-cell adhesion in angiogenesis (PubMed:16099422). Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn- glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27430; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2- dihexadecanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:43236, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:72859, ChEBI:CHEBI:82929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43237; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2- di-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:43244, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43245; Evidence=; Reaction=H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate; Xref=Rhea:RHEA:46736, ChEBI:CHEBI:15377, ChEBI:CHEBI:17408, ChEBI:CHEBI:43474, ChEBI:CHEBI:77589; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46737; Evidence=; Reaction=(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z- octadecenoyl)-glycerol + phosphate; Xref=Rhea:RHEA:50884, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:75937, ChEBI:CHEBI:84973; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50885; Evidence=; Reaction=H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine; Xref=Rhea:RHEA:27518, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27519; Evidence=; Reaction=an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4- enine + phosphate; Xref=Rhea:RHEA:33743, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52639, ChEBI:CHEBI:57674; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33744; Evidence=; Reaction=H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N- octanoylsphing-4-enine + phosphate; Xref=Rhea:RHEA:62040, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:45815, ChEBI:CHEBI:85376; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62041; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z- octadecenoyl) ethanolamine + phosphate; Xref=Rhea:RHEA:62160, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:71466, ChEBI:CHEBI:145465; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62161; Evidence=; Magnesium-independent phospholipid phosphatase. Insensitive to N-ethylmaleimide. Lipid metabolism; phospholipid metabolism. Forms functional homodimers and homooligomers that are not required for substrate recognition and catalytic activity. Can also form heterooligomers with other PLPP2 and PLPP3. Interacts with CTNND1; negatively regulates the PLPP3-mediated stabilization of beta- catenin/CTNNB1. Cell membrane ulti-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Membrane raft ; Multi-pass membrane protein Note=Cycles between the endoplasmic reticulum and the Golgi. Detected in lung, cerebellum and heart atrium. Display a characteristic dynamic and changing pattern of expression throughout the life cycle of the mouse (PubMed:12925589). Expression during early stages of development is specific of structures where multiple inductive interactions occur such as the limb buds, mammary gland primordia, heart cushions and valves among others (PubMed:19123136). Detected in a few cells of the extra- embryonic ectoderm of 6.5 dpc embryos. By 7.5 dpc, starts to be strongly expressed in the anterior visceral endoderm, as well as in the extra-embryonic membranes. By 8.0 dpc, expression extends to a highly localized region around the node and appears at the tip of the allantois. At 8.5 dpc, predominantly expressed in the allantois, the developing gut, the pericardio-peritoneal canal and somites. In 9.5 dpc embryos, persists in the umbilical cord, and is also found in the chorionic region. In later mid-gestation embryos, present at high levels in the apical ectodermal ridge and mesenchyme of the limb buds, in the peripheral nervous system, cranial nerves, and mammary gland primordia (PubMed:12925589). The integrin-binding motif mediates the binding to integrin alpha-5/beta-1 (ITGA5:ITGB1) and integrin alpha-V/beta-3 (ITGAV:ITGB3) and is required for the function in integrin-mediated cell-cell adhesion. The dityrosine basolateral targeting motif mediates localization to the basolateral membrane in polarized cells. N-glycosylated. Contains high-mannose oligosaccharides. The homozygous knockout of Plpp3 is embryonic lethal (PubMed:12925589, PubMed:17610274, PubMed:19123136). It is characterized by a delay in development, absence of chorioallantoic fusion at the 6 somite stage, allantois compaction, impaired remodeling of the primary capillary plexus of the yolk sac and gastrulation defects with low penetrance. Persistence of open neural tube is also frequently observed (PubMed:12925589, PubMed:19123136). Conditional knockout of Plpp3 in the cerebellum is associated with defects in postnatal cerebellum development, modifications in the cytoarchitecture and arrangement of Bergmann glia with a mild non-progressive motor coordination defect (PubMed:21319224). Conditional knockout of Plpp3 in endothelial cells is associated with vascular leakage and hemorrhage that likely result in insufficient cardiovascular development and the observed embryonic lethality (PubMed:27125875). Conditional knockout of Plpp3 in adipocytes does not affect the development of the adipose tissue. However, mutant homozygous mice display lower accumulation of ceramide and sphingomyelin on high fat or Western diets compared to control animals (PubMed:29889835). Belongs to the PA-phosphatase related phosphoesterase family. blood vessel development gastrulation with mouth forming second negative regulation of protein phosphorylation integrin binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane integral component of plasma membrane phospholipid metabolic process cell adhesion multicellular organism development phosphatidate phosphatase activity membrane integral component of membrane hydrolase activity phosphatase activity regulation of Wnt signaling pathway homotypic cell-cell adhesion sphingosine-1-phosphate phosphatase activity lipid phosphatase activity canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion canonical Wnt signaling pathway involved in positive regulation of wound healing phospholipid dephosphorylation positive regulation of peptidyl-tyrosine phosphorylation protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity Bergmann glial cell differentiation canonical Wnt signaling pathway cell-cell adhesion regulation of sphingolipid mediated signaling pathway uc008tye.1 uc008tye.2 uc008tye.3 
ENSMUST00000064141.12 Dcaf17 ENSMUST00000064141.12 DDB1 and CUL4 associated factor 17, transcript variant 2 (from RefSeq NM_001165981.1) A2AUU6 DCA17_MOUSE ENSMUST00000064141.1 ENSMUST00000064141.10 ENSMUST00000064141.11 ENSMUST00000064141.2 ENSMUST00000064141.3 ENSMUST00000064141.4 ENSMUST00000064141.5 ENSMUST00000064141.6 ENSMUST00000064141.7 ENSMUST00000064141.8 ENSMUST00000064141.9 NM_001165981 Q3TUL7 Q8C002 Q8K0F5 uc008kae.1 uc008kae.2 uc008kae.3 uc008kae.4 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Protein modification; protein ubiquitination. Interacts with DDB1, CUL4A and CUL4B. Membrane ; Multi-pass membrane protein Nucleus, nucleolus Note=According to PubMed:19026396, it is a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TUL7-1; Sequence=Displayed; Name=2; IsoId=Q3TUL7-2; Sequence=VSP_027789; Name=3; IsoId=Q3TUL7-3; Sequence=VSP_027790, VSP_027791; Ubiquitously expressed in the embryo, with higher expression in brain, liver and skin tissues. molecular_function nucleus nucleoplasm nucleolus cytosol biological_process membrane integral component of membrane protein ubiquitination Cul4-RING E3 ubiquitin ligase complex uc008kae.1 uc008kae.2 uc008kae.3 uc008kae.4 
ENSMUST00000064162.11 1700024B05Rik ENSMUST00000064162.11 1700024B05Rik (from geneSymbol) 1700024B05Rik AK006291 E9Q6D7 E9Q6D7_MOUSE ENSMUST00000064162.1 ENSMUST00000064162.10 ENSMUST00000064162.2 ENSMUST00000064162.3 ENSMUST00000064162.4 ENSMUST00000064162.5 ENSMUST00000064162.6 ENSMUST00000064162.7 ENSMUST00000064162.8 ENSMUST00000064162.9 uc288soo.1 uc288soo.2 molecular_function cellular_component biological_process uc288soo.1 uc288soo.2 
ENSMUST00000064166.5 Gpr20 ENSMUST00000064166.5 G protein-coupled receptor 20 (from RefSeq NM_173365.2) ENSMUST00000064166.1 ENSMUST00000064166.2 ENSMUST00000064166.3 ENSMUST00000064166.4 GPR20_MOUSE NM_173365 Q80T63 Q8BYC4 uc007wci.1 uc007wci.2 uc007wci.3 Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP. Cell membrane ; Multi-pass membrane protein Ubiquitous expressed with abundant expression in intestinal tissues. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane positive regulation of Rho protein signal transduction receptor complex positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway uc007wci.1 uc007wci.2 uc007wci.3 
ENSMUST00000064174.12 Cemip ENSMUST00000064174.12 cell migration inducing protein, hyaluronan binding (from RefSeq NM_030728.4) CEMIP_MOUSE E9QJS6 ENSMUST00000064174.1 ENSMUST00000064174.10 ENSMUST00000064174.11 ENSMUST00000064174.2 ENSMUST00000064174.3 ENSMUST00000064174.4 ENSMUST00000064174.5 ENSMUST00000064174.6 ENSMUST00000064174.7 ENSMUST00000064174.8 ENSMUST00000064174.9 Hybid Kiaa1199 NM_030728 Q6L9J4 Q8BI06 Q9EPQ3 Q9EPQ4 uc009idz.1 uc009idz.2 uc009idz.3 uc009idz.4 Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC- dependent manner. May be involved in hearing. Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D- glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35; Evidence=; Activity is up-regulated by histamine. Interacts with EPHA2 and ITPR3. Interacts with HSPA5/BIP; the interaction induces calcium leakage from the endoplasmic reticulum and cell migration. Interacts with clathrin heavy chain/CLTC (By similarity). Nucleus Cytoplasm Endoplasmic reticulum Cell membrane Membrane, clathrin-coated pit creted Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP-dependent manner. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas (By similarity). Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BI06-1; Sequence=Displayed; Name=2; IsoId=Q8BI06-2; Sequence=VSP_009816; Name=3; IsoId=Q8BI06-3; Sequence=VSP_009817; Expressed in Deiters' cells and various supporting cells in the organ of Corti including inner phalangeal, border, inner and outer pillar cells (at protein level). Weakly expressed in brain and testis. In ear, it is specifically expressed in inner ear. Expressed in Deiters' cells in the organ of Corti at P0 (postnatal day zero) before the onset of hearing, but disappears by day P7. Also expressed in fibrocytes of the spiral ligament and the spiral limbus through to P21, when the cochlea matures. Expressed throughout development. The signal sequence is essential in mediating its proper translocation, hyaluronic acid (HA) degradation activity and secretion. N-glycosylated; glycosylation is not necessary for HA-binding. Belongs to the CEMIP family. Sequence=AAH56981.1; Type=Erroneous initiation; Evidence=; Sequence=BAC29586.1; Type=Frameshift; Evidence=; hyalurononglucosaminidase activity hyaluronic acid binding extracellular region nucleus cytoplasm endoplasmic reticulum plasma membrane clathrin-coated pit sensory perception of sound metabolic process positive regulation of peptidyl-threonine phosphorylation membrane hydrolase activity hydrolase activity, acting on glycosyl bonds hyaluronan catabolic process positive regulation of cell migration clathrin-coated vesicle membrane clathrin heavy chain binding clathrin-coated endocytic vesicle ER retention sequence binding positive regulation of release of sequestered calcium ion into cytosol positive regulation of protein targeting to membrane positive regulation of protein kinase C activity uc009idz.1 uc009idz.2 uc009idz.3 uc009idz.4 
ENSMUST00000064190.13 Rai1 ENSMUST00000064190.13 retinoic acid induced 1, transcript variant 1 (from RefSeq NM_009021.2) B1AU87 ENSMUST00000064190.1 ENSMUST00000064190.10 ENSMUST00000064190.11 ENSMUST00000064190.12 ENSMUST00000064190.2 ENSMUST00000064190.3 ENSMUST00000064190.4 ENSMUST00000064190.5 ENSMUST00000064190.6 ENSMUST00000064190.7 ENSMUST00000064190.8 ENSMUST00000064190.9 Kiaa1820 NM_009021 Q61818 Q6ZPH7 Q8CEV1 RAI1_MOUSE uc007jfk.1 uc007jfk.2 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. Cytoplasm. Nucleus. Note=In neurons, localized to neurites. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61818-1; Sequence=Displayed; Name=2; IsoId=Q61818-2; Sequence=VSP_011004, VSP_011005; Detected in all tissues examined with strong expression in the thymus and brain. Expressed in epithelial cells involved in organogenesis. No expression was seen in the corpus callosum of the brain. Haploinsufficiency cause obesity and craniofacial abnormalities. Homozygous mice die during gastrulation and organogenesis. The few surviving mice experienced postnatal growth retardation and most of them died before weaning. skeletal system development transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytoplasm mitochondrion regulation of transcription from RNA polymerase II promoter circadian regulation of gene expression enhancer binding negative regulation of multicellular organism growth transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding rhythmic process uc007jfk.1 uc007jfk.2 
ENSMUST00000064192.8 Zdhhc19 ENSMUST00000064192.8 zinc finger, DHHC domain containing 19 (from RefSeq NM_199309.2) ENSMUST00000064192.1 ENSMUST00000064192.2 ENSMUST00000064192.3 ENSMUST00000064192.4 ENSMUST00000064192.5 ENSMUST00000064192.6 ENSMUST00000064192.7 Gm616 NM_199309 Q810M5 ZDH19_MOUSE uc007yyy.1 uc007yyy.2 uc007yyy.3 Palmitoyltransferase that mediates palmitoylation of RRAS, leading to increased cell viability. Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Q810M5; P62993: GRB2; Xeno; NbExp=2; IntAct=EBI-22225085, EBI-401755; Q810M5; P40763: STAT3; Xeno; NbExp=4; IntAct=EBI-22225085, EBI-518675; Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region The DHHC domain is required for palmitoyltransferase activity. Belongs to the DHHC palmitoyltransferase family. endoplasmic reticulum Golgi apparatus protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein-cysteine S-palmitoyltransferase activity uc007yyy.1 uc007yyy.2 uc007yyy.3 
ENSMUST00000064196.5 B630019K06Rik ENSMUST00000064196.5 RIKEN cDNA B630019K06 gene (from RefSeq NR_045448.1) B630019K06Rik ENSMUST00000064196.1 ENSMUST00000064196.2 ENSMUST00000064196.3 ENSMUST00000064196.4 NR_045448 Q7TNS5 Q7TNS5_MOUSE uc009spi.1 uc009spi.2 uc009spi.3 uc009spi.4 uc009spi.5 molecular_function cellular_component biological_process uc009spi.1 uc009spi.2 uc009spi.3 uc009spi.4 uc009spi.5 
ENSMUST00000064200.9 Tmem106c ENSMUST00000064200.9 transmembrane protein 106C, transcript variant 13 (from RefSeq NR_183250.1) D15Ertd405e ENSMUST00000064200.1 ENSMUST00000064200.2 ENSMUST00000064200.3 ENSMUST00000064200.4 ENSMUST00000064200.5 ENSMUST00000064200.6 ENSMUST00000064200.7 ENSMUST00000064200.8 NR_183250 Q80VP8 T106C_MOUSE uc007xln.1 uc007xln.2 uc007xln.3 uc007xln.4 Interacts with TMEM106B. Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Lipid-anchor Belongs to the TMEM106 family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane biological_process membrane integral component of membrane uc007xln.1 uc007xln.2 uc007xln.3 uc007xln.4 
ENSMUST00000064204.14 Actn2 ENSMUST00000064204.14 actinin alpha 2 (from RefSeq NM_033268.4) ACTN2_MOUSE ENSMUST00000064204.1 ENSMUST00000064204.10 ENSMUST00000064204.11 ENSMUST00000064204.12 ENSMUST00000064204.13 ENSMUST00000064204.2 ENSMUST00000064204.3 ENSMUST00000064204.4 ENSMUST00000064204.5 ENSMUST00000064204.6 ENSMUST00000064204.7 ENSMUST00000064204.8 ENSMUST00000064204.9 G3UW84 NM_033268 Q9JI91 uc007pli.1 uc007pli.2 uc007pli.3 uc007pli.4 F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C- terminal region with the LDB3 PDZ domain. Interacts with XIRP2. Interacts with DST (via N-terminus). Interacts with PARVB. Interacts with SYNPO2 (By similarity). Q9JI91; P11798: Camk2a; NbExp=3; IntAct=EBI-299169, EBI-400384; Q9JI91; Q01097: Grin2b; NbExp=2; IntAct=EBI-299169, EBI-400125; Cytoplasm, myofibril, sarcomere, Z line Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle. Ubiquitinated by FBXL22, leading to proteasomal degradation. Belongs to the alpha-actinin family. actin binding calcium ion binding protein binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm striated muscle thin filament plasma membrane focal adhesion muscle contraction cytoskeletal protein binding protein domain specific binding sarcomere Z disc microspike assembly filopodium LIM domain binding ligand-dependent nuclear receptor transcription coactivator activity thyroid hormone receptor coactivator activity protein binding, bridging cortical actin cytoskeleton titin binding regulation of membrane potential identical protein binding protein homodimerization activity negative regulation of potassium ion transport positive regulation of potassium ion transport ion channel binding sarcomere organization metal ion binding protein dimerization activity focal adhesion assembly actin filament binding protein homotetramerization FATZ binding actin filament uncapping cardiac muscle cell development titin Z domain binding protein localization to plasma membrane phospholipase C-activating angiotensin-activated signaling pathway postsynaptic density membrane glutamatergic synapse postsynaptic density, intracellular component negative regulation of potassium ion transmembrane transporter activity positive regulation of potassium ion transmembrane transporter activity positive regulation of nucleic acid-templated transcription negative regulation of protein localization to cell surface positive regulation of endocytic recycling positive regulation of cation channel activity uc007pli.1 uc007pli.2 uc007pli.3 uc007pli.4 
ENSMUST00000064214.4 Rnase9 ENSMUST00000064214.4 ribonuclease, RNase A family, 9 (non-active) (from RefSeq NM_183032.2) ENSMUST00000064214.1 ENSMUST00000064214.2 ENSMUST00000064214.3 NM_183032 Q5QJV3 Q5QJV3_MOUSE Rak1 Rnase9 uc007tmh.1 uc007tmh.2 uc007tmh.3 Does not exhibit any ribonuclease activity. Belongs to the pancreatic ribonuclease family. nucleic acid binding uc007tmh.1 uc007tmh.2 uc007tmh.3 
ENSMUST00000064230.16 Rft1 ENSMUST00000064230.16 RFT1 homolog, transcript variant 9 (from RefSeq NR_189626.1) B2RUN9 ENSMUST00000064230.1 ENSMUST00000064230.10 ENSMUST00000064230.11 ENSMUST00000064230.12 ENSMUST00000064230.13 ENSMUST00000064230.14 ENSMUST00000064230.15 ENSMUST00000064230.2 ENSMUST00000064230.3 ENSMUST00000064230.4 ENSMUST00000064230.5 ENSMUST00000064230.6 ENSMUST00000064230.7 ENSMUST00000064230.8 ENSMUST00000064230.9 NR_189626 Q8C3B8 RFT1_MOUSE uc007svn.1 uc007svn.2 uc007svn.3 uc007svn.4 May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane (By similarity). Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C3B8-1; Sequence=Displayed; Name=2; IsoId=Q8C3B8-2; Sequence=VSP_029509, VSP_029510; Belongs to the RFT1 family. molecular_function lipid transporter activity endoplasmic reticulum membrane lipid transport carbohydrate transport membrane integral component of membrane glycolipid translocation uc007svn.1 uc007svn.2 uc007svn.3 uc007svn.4 
ENSMUST00000064231.8 Mogat2 ENSMUST00000064231.8 monoacylglycerol O-acyltransferase 2 (from RefSeq NM_177448.4) Dgat2l5 ENSMUST00000064231.1 ENSMUST00000064231.2 ENSMUST00000064231.3 ENSMUST00000064231.4 ENSMUST00000064231.5 ENSMUST00000064231.6 ENSMUST00000064231.7 MOGT2_MOUSE Mgat1l Mogat2 NM_177448 Q80W94 uc009ilf.1 uc009ilf.2 uc009ilf.3 uc009ilf.4 Involved in glycerolipid synthesis and lipid metabolism (PubMed:12576479, PubMed:12730219, PubMed:14966132, PubMed:12621063). Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes (Probable). Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol (PubMed:12621063, PubMed:12730219). Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0 (PubMed:12730219). Able to use 1-monoalkylglycerol (1-MAkG, 1-O-alkylglycerol) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG, 1-O- alkyl-3-acylglycerol) (PubMed:12730219). Possesses weak but significant activity with diacylglycerol as substrate, producing triacylglycerol (triacyl-sn-glycerol) (PubMed:12730219). Reaction=a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA; Xref=Rhea:RHEA:16741, ChEBI:CHEBI:17389, ChEBI:CHEBI:49172, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; EC=2.3.1.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16742; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77539, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:73990, ChEBI:CHEBI:197391; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77540; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl- 2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77275, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:73990, ChEBI:CHEBI:75579; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77276; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1- hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77283, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:73990, ChEBI:CHEBI:75585; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77284; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1- octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77287, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:73990, ChEBI:CHEBI:75590; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77288; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:39951, ChEBI:CHEBI:52323, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:73990; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39952; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77291, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:73990, ChEBI:CHEBI:75614; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77292; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA = 1-eicosanoyl- 2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77543, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:73990, ChEBI:CHEBI:197392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77544; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)- glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)- glycerol + CoA; Xref=Rhea:RHEA:77547, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:73990, ChEBI:CHEBI:75611; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77548; Evidence=; Reaction=a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA; Xref=Rhea:RHEA:32947, ChEBI:CHEBI:17389, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32948; Evidence=; Reaction=a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA; Xref=Rhea:RHEA:38467, ChEBI:CHEBI:17389, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:75524; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38468; Evidence=; Reaction=a 1-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA; Xref=Rhea:RHEA:39943, ChEBI:CHEBI:35759, ChEBI:CHEBI:49172, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39944; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-2- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38115, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75539, ChEBI:CHEBI:75579; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38116; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1- tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38119, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75562, ChEBI:CHEBI:75582; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38120; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1- hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38123, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:69081, ChEBI:CHEBI:75585; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38124; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:37915, ChEBI:CHEBI:52323, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37916; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75568, ChEBI:CHEBI:75614; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38132; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)- glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)- glycerol + CoA; Xref=Rhea:RHEA:38135, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75609, ChEBI:CHEBI:75610; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38136; Evidence=; Reaction=a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA; Xref=Rhea:RHEA:77571, ChEBI:CHEBI:35759, ChEBI:CHEBI:47777, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77572; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octanoylglycerol = 1-octanoyl-3-(9Z- octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77579, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:85241, ChEBI:CHEBI:197405; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77580; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-3- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77587, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75539, ChEBI:CHEBI:197406; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77588; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1-(9Z- octadecenoyl)-3-hexadecanoylglycerol + CoA; Xref=Rhea:RHEA:77563, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:69081, ChEBI:CHEBI:75869; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77564; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1- octadecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77583, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75555, ChEBI:CHEBI:197407; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77584; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycerol = 1,3- di-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77267, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75735, ChEBI:CHEBI:75757; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77268; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol = 1-(9Z-octadecenoyl)-3-(9Z,12Z-octadecadienoyl)-glycerol + CoA; Xref=Rhea:RHEA:77591, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75568, ChEBI:CHEBI:133484; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77592; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)- glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-3-(9Z-octadecenoyl)- glycerol + CoA; Xref=Rhea:RHEA:77595, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75610, ChEBI:CHEBI:197408; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77596; Evidence=; Reaction=1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA; Xref=Rhea:RHEA:77627, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:76225, ChEBI:CHEBI:77997; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77628; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-O-hexadecylglycerol = 1-O-hexadecyl- 3-(9Z)-octadecenoylglycerol + CoA; Xref=Rhea:RHEA:77575, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:76061, ChEBI:CHEBI:76062; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77576; Evidence=; Reaction=a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA; Xref=Rhea:RHEA:10868, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64615; EC=2.3.1.20; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10869; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219, ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38220; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77271, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371, ChEBI:CHEBI:73990, ChEBI:CHEBI:197386; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77272; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1- tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77279, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:73990, ChEBI:CHEBI:75582; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77280; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-decanoylglycerol = 1-decanoyl-2-(9Z- octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75547, ChEBI:CHEBI:85787; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38020; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1- octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38127, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75555, ChEBI:CHEBI:75590; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38128; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)- glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)- glycerol + CoA; Xref=Rhea:RHEA:38139, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75611, ChEBI:CHEBI:75612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38140; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-decanoylglycerol = 1-decanoyl-3-(9Z- octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77615, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75547, ChEBI:CHEBI:197430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77616; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1- tetradecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77631, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75562, ChEBI:CHEBI:197427; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77632; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)- glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)- glycerol + CoA; Xref=Rhea:RHEA:77635, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75612, ChEBI:CHEBI:197426; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77636; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O- (9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:55340, ChEBI:CHEBI:34116, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:197429; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55341; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecyl)-3-(9Z- octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z- octadecenoyl)glycerol + CoA; Xref=Rhea:RHEA:55344, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:138735, ChEBI:CHEBI:197429; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55345; Evidence=; Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid. pH dependence: Optimum pH is 7.0. ; Glycerolipid metabolism; triacylglycerol biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region Mainly expressed in small intestine. Detected in the small intestine in a proximal-to-distal gradient that correlated with fat absorption pattern. Present not only in the villi, but also in the crypt regions of the small intestine, which suggests that expression occurs prior to the maturation of enterocytes. Not detectable in other sections of the digestive tract, including stomach, cecum, colon and rectum, or other tissues such as kidney, liver and adipocytes (at protein level). Also detected in kidney, adipose and stomach. Expressed at very low level in liver, skeletal muscle and spleen. Not expressed in brain, heart, lung, skin, testis and thymus. Up-regulated in mice fed a high fat diet, implicating a role in diet-induced obesity (at protein level). Belongs to the diacylglycerol acyltransferase family. 2-acylglycerol O-acyltransferase activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane glycerol metabolic process lipid metabolic process diacylglycerol biosynthetic process membrane integral component of membrane acetyltransferase activity transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups triglyceride biosynthetic process monoacylglycerol metabolic process perinuclear region of cytoplasm intestinal absorption perinuclear endoplasmic reticulum membrane uc009ilf.1 uc009ilf.2 uc009ilf.3 uc009ilf.4 
ENSMUST00000064234.7 Ezr ENSMUST00000064234.7 ezrin (from RefSeq NM_009510.2) ENSMUST00000064234.1 ENSMUST00000064234.2 ENSMUST00000064234.3 ENSMUST00000064234.4 ENSMUST00000064234.5 ENSMUST00000064234.6 Ezr NM_009510 Q4KML7 Q4KML7_MOUSE Vil2 uc008ahv.1 uc008ahv.2 uc008ahv.3 Apical cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, microvillus membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cell cortex Cytoplasm, cytoskeleton Membrane ; Peripheral membrane protein ; Cytoplasmic side negative regulation of transcription from RNA polymerase II promoter fibrillar center ruffle immunological synapse sphingosine-1-phosphate signaling pathway actin binding cytoplasm endosome cytosol cytoskeleton actin filament plasma membrane microvillus focal adhesion leukocyte cell-cell adhesion microtubule binding cytoskeletal protein binding regulation of cell shape positive regulation of gene expression protein kinase A signaling actin cytoskeleton basolateral plasma membrane apical plasma membrane extrinsic component of membrane protein domain specific binding membrane to membrane docking microvillus assembly filopodium T-tubule epithelial cell differentiation astral microtubule organization microvillus membrane actin cytoskeleton reorganization macromolecular complex protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding cellular protein complex localization identical protein binding cell projection cortical microtubule organization cell body microspike S100 protein binding plasma membrane raft macromolecular complex binding membrane raft apical part of cell filopodium assembly phosphatidylinositol-mediated signaling perinuclear region of cytoplasm positive regulation of protein secretion cell adhesion molecule binding negative regulation of T cell receptor signaling pathway actin filament binding actin filament bundle assembly protein kinase A binding ATPase binding cell tip establishment of centrosome localization establishment of endothelial barrier negative regulation of ERK1 and ERK2 cascade cellular response to cAMP invadopodium cell periphery protein localization to plasma membrane protein localization to cell cortex astrocyte projection Schwann cell microvillus cytoplasmic side of apical plasma membrane negative regulation of interleukin-2 secretion regulation of organelle assembly positive regulation of protein localization to early endosome positive regulation of cellular protein catabolic process negative regulation of p38MAPK cascade positive regulation of early endosome to late endosome transport uc008ahv.1 uc008ahv.2 uc008ahv.3 
ENSMUST00000064244.11 Rexo4 ENSMUST00000064244.11 REX4, 3'-5' exonuclease, transcript variant 3 (from RefSeq NR_156410.1) A2ALB2 A2ALB2_MOUSE ENSMUST00000064244.1 ENSMUST00000064244.10 ENSMUST00000064244.2 ENSMUST00000064244.3 ENSMUST00000064244.4 ENSMUST00000064244.5 ENSMUST00000064244.6 ENSMUST00000064244.7 ENSMUST00000064244.8 ENSMUST00000064244.9 NR_156410 Rexo4 uc008iwn.1 uc008iwn.2 uc008iwn.3 Belongs to the REXO4 family. nucleic acid binding rRNA processing 3'-5' exonuclease activity nucleic acid phosphodiester bond hydrolysis uc008iwn.1 uc008iwn.2 uc008iwn.3 
ENSMUST00000064257.6 Tchh ENSMUST00000064257.6 trichohyalin (from RefSeq NM_001163098.2) A0A0B4J1F9 A0A0B4J1F9_MOUSE ENSMUST00000064257.1 ENSMUST00000064257.2 ENSMUST00000064257.3 ENSMUST00000064257.4 ENSMUST00000064257.5 NM_001163098 Tchh uc012cti.1 uc012cti.2 calcium ion binding protein binding, bridging intermediate filament organization metal ion binding transition metal ion binding uc012cti.1 uc012cti.2 
ENSMUST00000064265.13 Pla2g3 ENSMUST00000064265.13 phospholipase A2, group III (from RefSeq NM_172791.2) ENSMUST00000064265.1 ENSMUST00000064265.10 ENSMUST00000064265.11 ENSMUST00000064265.12 ENSMUST00000064265.2 ENSMUST00000064265.3 ENSMUST00000064265.4 ENSMUST00000064265.5 ENSMUST00000064265.6 ENSMUST00000064265.7 ENSMUST00000064265.8 ENSMUST00000064265.9 NM_172791 PA2G3_MOUSE Pla2g3 Q8BZT7 uc007hsz.1 uc007hsz.2 uc007hsz.3 Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids without apparent head group selectivity (PubMed:20424323). Contributes to phospholipid remodeling of low-density lipoprotein (LDL) and high- density lipoprotein (HDL) particles. Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (By similarity). May act in an autocrine and paracrine manner (PubMed:23624557). Secreted by immature mast cells, acts on nearby fibroblasts upstream to PTDGS to synthesize prostaglandin D2 (PGD2), which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557). Secreted by epididymal epithelium, acts on immature sperm cells within the duct, modulating the degree of unsaturation of the fatty acyl components of phosphatidylcholines required for acrosome assembly and sperm cell motility (PubMed:20424323). Facilitates the replacement of fatty acyl chains in phosphatidylcholines in sperm membranes from omega-6 and omega-9 to omega-3 polyunsaturated fatty acids (PUFAs) (PubMed:20424323). Coupled to lipoxygenase pathway, may process omega-6 PUFAs to generate oxygenated lipid mediators in the male reproductive tract (PubMed:20424323). At pericentrosomal preciliary compartment, negatively regulates ciliogenesis likely by regulating endocytotic recycling of ciliary membrane protein (By similarity). Coupled to cyclooxygenase pathway provides arachidonate to generate prostaglandin E2 (PGE2), a potent immunomodulatory lipid in inflammation and tumorigenesis (By similarity). At colonic epithelial barrier, preferentially hydrolyzes phospholipids having arachidonate and docosahexaenoate at sn-2 position, contributing to the generation of oxygenated metabolites involved in colonic stem cell homeostasis (PubMed:28947740). Releases C16:0 and C18:0 lysophosphatidylcholine subclasses from neuron plasma membranes and promotes neurite outgrowth and neuron survival (PubMed:17868035). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn- glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40812; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40432; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion. ; Secreted Cell membrane Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Recycling endosome Note=Localized at pericentrosomal preciliary compartment. Expressed in dermal mast cells (at protein level) (PubMed:23624557). Highly expressed in EPCAM-positive colonic epithelial cells throughout the proximal to distal colon (at protein level) (PubMed:28947740). Expressed at lower levels in ileum section of small intestine and immune organs including bone marrow, spleen and lymph nodes (PubMed:28947740, PubMed:20424323). Expressed in stomach and lung (at protein level) (PubMed:17868035). Expressed in testis and epididymis and to a lesser extent in the seminal vesicles and prostate (PubMed:20424323). Detected in ovary, oviduct and uterus (PubMed:20424323). Expressed in Sertoli and Leydig cells as well as in epididymal epithelium particularly in apical border of principal cells in the corpus (at protein level) (PubMed:20424323). Present in cauda epididymal fluid (at protein level) (PubMed:20424323). Expressed in central nervous system, with high levels in spinal cord and at a lesser extent in brain (at protein level) (PubMed:17868035, PubMed:20424323). Highly expressed in dorsal root ganglia of the developing brain at 12.5 dpc (at protein level). The phospholipase A2-like domain represents the fully processed form after N- and C-termini are cleaved off. It is the secreted mature form found in biological fluids. N-glycosylation does not affect the catalytic activity, but is required for proper secretion. A nonglycosylated form is observed in several cell types. In several cell types, the N- and C-termini are cleaved off. Male mutant mice have reduced fertility associated with reduced sperm cell motility, aberrant acrosomes and flagella resulting in poor morula development. The litter size after intercrossing heterozygous mutant male and female mice is significantly smaller when compared to wild-type mice. Nevertheless, mutant offspring are born at approximately Mendelian proportions, have normal survival, appearance and behavior (PubMed:20424323). Mutant mice are resistant to both passive systemic and active cutaneous anaphylaxis (PubMed:23624557). In models of colon carcinogenesis either induced by azoxymethane procarcinogen or upon activation of oncogenic Wnt/beta- catenin signal due to a mutation in the APC gene (model of human familial adenomatous polyposis), mutant mice are resistant to tumorigeneis showing markedly decreased total tumor burden in the colon. In a colitis model induced by toxic dextran sulfate sodium, mutant mice are protected from shortening of the colon length and mucosal inflammation and rapidly recover from epithelial injury (PubMed:28947740). Belongs to the phospholipase A2 family. acrosome assembly molecular_function phospholipase A2 activity extracellular region centriole phospholipid metabolic process sperm axoneme assembly lipoxygenase pathway mast cell granule mast cell degranulation phosphatidylcholine metabolic process cell development arachidonic acid secretion cilium assembly uc007hsz.1 uc007hsz.2 uc007hsz.3 
ENSMUST00000064272.10 B4galt3 ENSMUST00000064272.10 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 (from RefSeq NM_020579.2) B4GT3_MOUSE B4galt3 ENSMUST00000064272.1 ENSMUST00000064272.2 ENSMUST00000064272.3 ENSMUST00000064272.4 ENSMUST00000064272.5 ENSMUST00000064272.6 ENSMUST00000064272.7 ENSMUST00000064272.8 ENSMUST00000064272.9 NM_020579 Q91YY2 Q9QY13 uc007dnp.1 uc007dnp.2 uc007dnp.3 Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Reaction=an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D- galactose = a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:22932, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:61631, ChEBI:CHEBI:66914, ChEBI:CHEBI:133507; EC=2.4.1.38; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22933; Evidence=; Reaction=N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D- galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP; Xref=Rhea:RHEA:17745, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:60152, ChEBI:CHEBI:66914, ChEBI:CHEBI:506227; EC=2.4.1.90; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17746; Evidence=; Reaction=a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)- Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:31499, ChEBI:CHEBI:15378, ChEBI:CHEBI:17006, ChEBI:CHEBI:17103, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914; EC=2.4.1.275; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31500; Evidence=; Reaction=beta-D-glucosylceramide + UDP-alpha-D-galactose = a beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP; Xref=Rhea:RHEA:62552, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:79208, ChEBI:CHEBI:83264; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62553; Evidence=; Reaction=a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D- galactose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl- (1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)- beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP; Xref=Rhea:RHEA:62548, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:90357, ChEBI:CHEBI:144378; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62549; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Note=Trans cisternae of Golgi stack. Belongs to the glycosyltransferase 7 family. Name=Functional Glycomics Gateway - GTase; Note=b4GalT3; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_462"; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity N-acetyllactosamine synthase activity Golgi apparatus cytosol carbohydrate metabolic process protein glycosylation galactosylceramide biosynthetic process galactosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups Golgi cisterna membrane metal ion binding uc007dnp.1 uc007dnp.2 uc007dnp.3 
ENSMUST00000064285.15 Glcci1 ENSMUST00000064285.15 glucocorticoid induced transcript 1, transcript variant 1 (from RefSeq NM_133236.3) E9QKK4 E9QKK4_MOUSE ENSMUST00000064285.1 ENSMUST00000064285.10 ENSMUST00000064285.11 ENSMUST00000064285.12 ENSMUST00000064285.13 ENSMUST00000064285.14 ENSMUST00000064285.2 ENSMUST00000064285.3 ENSMUST00000064285.4 ENSMUST00000064285.5 ENSMUST00000064285.6 ENSMUST00000064285.7 ENSMUST00000064285.8 ENSMUST00000064285.9 Glcci1 NM_133236 uc009axt.1 uc009axt.2 uc009axt.3 uc009axt.4 uc009axt.1 uc009axt.2 uc009axt.3 uc009axt.4 
ENSMUST00000064290.8 Cebpe ENSMUST00000064290.8 CCAAT/enhancer binding protein epsilon (from RefSeq NM_207131.2) CEBPE_MOUSE ENSMUST00000064290.1 ENSMUST00000064290.2 ENSMUST00000064290.3 ENSMUST00000064290.4 ENSMUST00000064290.5 ENSMUST00000064290.6 ENSMUST00000064290.7 Gm294 NM_207131 Q32MW9 Q6PZD9 uc007twz.1 uc007twz.2 uc007twz.3 Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation. Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPD (By similarity). Interacts with GATA1 and SPI1 (By similarity). Interacts with SMARCD2 (By similarity). Nucleus Phosphorylated. Belongs to the bZIP family. C/EBP subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated phagocytosis positive regulation of gene expression myeloid cell differentiation macrophage differentiation granulocyte differentiation cytokine biosynthetic process defense response to bacterium protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity cellular response to lipopolysaccharide uc007twz.1 uc007twz.2 uc007twz.3 
ENSMUST00000064314.10 Get3 ENSMUST00000064314.10 guided entry of tail-anchored proteins factor 3, ATPase, transcript variant 1 (from RefSeq NM_019652.2) Arsa Asna1 ENSMUST00000064314.1 ENSMUST00000064314.2 ENSMUST00000064314.3 ENSMUST00000064314.4 ENSMUST00000064314.5 ENSMUST00000064314.6 ENSMUST00000064314.7 ENSMUST00000064314.8 ENSMUST00000064314.9 GET3_MOUSE Get3 NM_019652 O54984 Q3TAQ4 uc009mox.1 uc009mox.2 uc009mox.3 ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. Homodimer. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40. Within the complex, CAMLG and GET1 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer. Interacts with CAMLG/GET2 (via N-terminus). GET3 shows a higher affinity for CAMLG than for GET1. Interacts with SERP1 and SEC61B. Cytoplasm Endoplasmic reticulum Nucleus, nucleolus Causes early embryonic lethality. Belongs to the arsA ATPase family. nucleotide binding ATP binding nucleus nucleolus cytoplasm endoplasmic reticulum posttranslational protein targeting to membrane hydrolase activity ATPase activity GET complex protein insertion into ER membrane metal ion binding tail-anchored membrane protein insertion into ER membrane uc009mox.1 uc009mox.2 uc009mox.3 
ENSMUST00000064324.12 Try5 ENSMUST00000064324.12 trypsin 5 (from RefSeq NM_001003405.4) ENSMUST00000064324.1 ENSMUST00000064324.10 ENSMUST00000064324.11 ENSMUST00000064324.2 ENSMUST00000064324.3 ENSMUST00000064324.4 ENSMUST00000064324.5 ENSMUST00000064324.6 ENSMUST00000064324.7 ENSMUST00000064324.8 ENSMUST00000064324.9 NM_001003405 Q9QUK9 TRY5_MOUSE Tc Tesp4 Try5 uc009bot.1 uc009bot.2 uc009bot.3 uc009bot.4 Serine protease capable of autoactivation. Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4; Evidence=; Activated by autocatalytic cleavage (PubMed:23814066). Cleavage by CTRC inhibits autoactivation (PubMed:23814066). Cytoplasmic vesicle, secretory vesicle, acrosome Expressed in the heart, lung, brain, kidney, liver, epididymis, ovary and uterus. Expression in the testis is limited to round and elongating spermatids. Expressed in the testis from 20 days of age onwards. Proteolytically cleaved and activated by an autocatalytic mechanism (PubMed:23814066). Cleavage by CTRC inhibits autoactivation (PubMed:23814066). Belongs to the peptidase S1 family. serine-type endopeptidase activity calcium ion binding extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009bot.1 uc009bot.2 uc009bot.3 uc009bot.4 
ENSMUST00000064341.9 Sp140l2 ENSMUST00000064341.9 Sp140 nuclear body protein like 2, transcript variant 2 (from RefSeq NM_001037909.3) C130026I21Rik ENSMUST00000064341.1 ENSMUST00000064341.2 ENSMUST00000064341.3 ENSMUST00000064341.4 ENSMUST00000064341.5 ENSMUST00000064341.6 ENSMUST00000064341.7 ENSMUST00000064341.8 NM_001037909 Q3KNJ6 Q3KNJ6_MOUSE Sp140l2 uc007btu.1 uc007btu.2 uc007btu.3 cellular_component nucleus nuclear body uc007btu.1 uc007btu.2 uc007btu.3 
ENSMUST00000064347.8 Tmem171 ENSMUST00000064347.8 transmembrane protein 171, transcript variant 1 (from RefSeq NM_001373965.1) ENSMUST00000064347.1 ENSMUST00000064347.2 ENSMUST00000064347.3 ENSMUST00000064347.4 ENSMUST00000064347.5 ENSMUST00000064347.6 ENSMUST00000064347.7 Gm905 NM_001373965 Q4KL18 TM171_MOUSE uc007roy.1 uc007roy.2 uc007roy.3 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007roy.1 uc007roy.2 uc007roy.3 
ENSMUST00000064370.6 Pkdrej ENSMUST00000064370.6 polycystin (PKD) family receptor for egg jelly (from RefSeq NM_011105.2) ENSMUST00000064370.1 ENSMUST00000064370.2 ENSMUST00000064370.3 ENSMUST00000064370.4 ENSMUST00000064370.5 F8VQF3 F8VQF3_MOUSE NM_011105 Pkdrej uc007xdm.1 uc007xdm.2 uc007xdm.3 Membrane ; Multi- pass membrane protein Belongs to the polycystin family. Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding membrane integral component of membrane uc007xdm.1 uc007xdm.2 uc007xdm.3 
ENSMUST00000064371.14 Magi3 ENSMUST00000064371.14 membrane associated guanylate kinase, WW and PDZ domain containing 3, transcript variant 2 (from RefSeq NM_133853.3) B0V3N7 B0V3N8 ENSMUST00000064371.1 ENSMUST00000064371.10 ENSMUST00000064371.11 ENSMUST00000064371.12 ENSMUST00000064371.13 ENSMUST00000064371.2 ENSMUST00000064371.3 ENSMUST00000064371.4 ENSMUST00000064371.5 ENSMUST00000064371.6 ENSMUST00000064371.7 ENSMUST00000064371.8 ENSMUST00000064371.9 Kiaa1634 MAGI3_MOUSE NM_133853 Q69ZE1 Q8C0P8 Q9EQJ9 uc008qua.1 uc008qua.2 uc008qua.3 uc008qua.4 uc008qua.5 Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. Interacts with ADRB1, ADGRB1, LPAR2/EDG4, GRIN2B, PTEN, and PTPRB. Interacts with unidentified tyrosine phosphorylated proteins (By similarity). Interacts with FZD4, FZD7, TGFA and VANGL2. Interacts with DLL1 (PubMed:15509766). Interacts with PRRG4 (via cytoplasmic domain) (By similarity). Q9EQJ9; P01135: TGFA; Xeno; NbExp=4; IntAct=EBI-7455245, EBI-1034374; Cell membrane ; Peripheral membrane protein Cell junction, tight junction Nucleus Note=Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EQJ9-1; Sequence=Displayed; Name=2; IsoId=Q9EQJ9-2; Sequence=VSP_034288, VSP_034289; Widely expressed. Colocalizes with TGFA in neurons in the cortex and dentate gyrus, as well as in ependymal cells and some astrocytes (at protein level). Present in lens epithelium. Belongs to the MAGUK family. Sequence=BAD32503.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence=; nucleotide binding frizzled binding protein binding ATP binding nucleus cytoplasm plasma membrane cell-cell junction bicellular tight junction signal transduction membrane cell junction positive regulation of JUN kinase activity regulation of JNK cascade binding, bridging uc008qua.1 uc008qua.2 uc008qua.3 uc008qua.4 uc008qua.5 
ENSMUST00000064376.13 Arhgap4 ENSMUST00000064376.13 Rho GTPase activating protein 4, transcript variant 1 (from RefSeq NM_138630.2) Arhgap4 ENSMUST00000064376.1 ENSMUST00000064376.10 ENSMUST00000064376.11 ENSMUST00000064376.12 ENSMUST00000064376.2 ENSMUST00000064376.3 ENSMUST00000064376.4 ENSMUST00000064376.5 ENSMUST00000064376.6 ENSMUST00000064376.7 ENSMUST00000064376.8 ENSMUST00000064376.9 NM_138630 Q80Z68 Q80Z68_MOUSE uc009tna.1 uc009tna.2 uc009tna.3 uc009tna.4 GTPase activator activity cytoplasm Golgi apparatus microtubule signal transduction nervous system development negative regulation of fibroblast migration negative regulation of cell migration growth cone negative regulation of axon extension identical protein binding positive regulation of GTPase activity Rac GTPase binding uc009tna.1 uc009tna.2 uc009tna.3 uc009tna.4 
ENSMUST00000064377.7 Gcc1 ENSMUST00000064377.7 Probably involved in maintaining Golgi structure. (from UniProt Q9D4H2) AK016531 ENSMUST00000064377.1 ENSMUST00000064377.2 ENSMUST00000064377.3 ENSMUST00000064377.4 ENSMUST00000064377.5 ENSMUST00000064377.6 GCC1_MOUSE Q8CCR3 Q9D4H2 uc291cyw.1 uc291cyw.2 Probably involved in maintaining Golgi structure. Cytoplasm. Golgi apparatus membrane ; Peripheral membrane protein Extended rod-like protein with coiled-coil domains. Golgi membrane molecular_function cytoplasm Golgi apparatus cytosol plasma membrane biological_process membrane uc291cyw.1 uc291cyw.2 
ENSMUST00000064391.12 Cpne8 ENSMUST00000064391.12 copine VIII, transcript variant 1 (from RefSeq NM_025815.2) B2RS65 CPNE8_MOUSE Cpne8 ENSMUST00000064391.1 ENSMUST00000064391.10 ENSMUST00000064391.11 ENSMUST00000064391.2 ENSMUST00000064391.3 ENSMUST00000064391.4 ENSMUST00000064391.5 ENSMUST00000064391.6 ENSMUST00000064391.7 ENSMUST00000064391.8 ENSMUST00000064391.9 NM_025815 Q9CUZ8 Q9DC53 uc007xhn.1 uc007xhn.2 uc007xhn.3 This gene encodes a member of the copine family of highly conserved, calcium-dependent phospholipid binding proteins. The encoded protein has two characteristic C2 domains and a VWFA domain and may play a role in membrane trafficking. A related pseudogene is found on chromosome 8. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per C2 domain. Belongs to the copine family. It is uncertain whether Met-1 or Met-14 is the initiator. calcium-dependent phospholipid binding plasma membrane cellular response to calcium ion uc007xhn.1 uc007xhn.2 uc007xhn.3 
ENSMUST00000064393.6 Rcl1 ENSMUST00000064393.6 RNA terminal phosphate cyclase-like 1 (from RefSeq NM_021525.2) ENSMUST00000064393.1 ENSMUST00000064393.2 ENSMUST00000064393.3 ENSMUST00000064393.4 ENSMUST00000064393.5 NM_021525 Q9JJT0 RCL1_MOUSE Rnac uc008hda.1 uc008hda.2 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome (By similarity). Does not have cyclase activity (By similarity). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) catalytic activity endoribonuclease activity nucleus nucleolus rRNA processing RNA processing ribosome biogenesis RNA-3'-phosphate cyclase activity uc008hda.1 uc008hda.2 
ENSMUST00000064404.8 Glrx3 ENSMUST00000064404.8 glutaredoxin 3, transcript variant 1 (from RefSeq NM_023140.5) ENSMUST00000064404.1 ENSMUST00000064404.2 ENSMUST00000064404.3 ENSMUST00000064404.4 ENSMUST00000064404.5 ENSMUST00000064404.6 ENSMUST00000064404.7 GLRX3_MOUSE NM_023140 Picot Q5I0V8 Q9CQM9 Q9JLZ2 Txnl2 uc009kex.1 uc009kex.2 uc009kex.3 Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (PubMed:16809552, PubMed:18258855, PubMed:18929570). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). Homodimer; the homodimer is independent of 2Fe-2S clusters. Heterotrimer; forms a heterotrimeric complex composed by two BOLA2 molecules and one GLRX3 molecule; linked by [2Fe-2S] clusters. Interacts (via N-terminus) with PRKCQ/PKC-theta (By similarity). Interacts (via C-terminus) with CSRP3 (PubMed:18258855). Interacts with CSRP2 (PubMed:18258855). Q9CQM9; Q8WTY4: Ciapin1; NbExp=4; IntAct=EBI-4319195, EBI-2943068; Cytoplasm, cytosol Cytoplasm, cell cortex Cytoplasm, myofibril, sarcomere, Z line Note=Under the plasma membrane (PubMed:18258855). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (PubMed:18258855). In the Z line, found associated with CSRP3 (PubMed:18258855). The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity. Homozygous null mutants die in utero some time between 12.5 and 14.5 dpc. 12.5 dpc embryos have a smaller body size and hemorrhage in the head. Heterozygous mutants are fertile and show no abnormalities in growth and development, cardiomyocytes exhibit significantly reduced contractility. Transgenic mice with cardiac-specific Glrx3 overexpression show that it is a potent inhibitor of cardiac hypertrophy induced by pressure overload (transverse aortic constriction). In addition, overexpression dramatically increases the ventricular function and cardiomyocyte contractility. regulation of the force of heart contraction protein kinase C binding protein binding nucleus cytoplasm cytosol cell cortex cellular iron ion homeostasis electron carrier activity negative regulation of cardiac muscle hypertrophy protein disulfide oxidoreductase activity electron transport chain Z disc dendrite identical protein binding [2Fe-2S] cluster assembly cell redox homeostasis metal ion binding iron-sulfur cluster binding oxidation-reduction process protein maturation by iron-sulfur cluster transfer uc009kex.1 uc009kex.2 uc009kex.3 
ENSMUST00000064405.8 Epha3 ENSMUST00000064405.8 Eph receptor A3, transcript variant 1 (from RefSeq NM_010140.4) ENSMUST00000064405.1 ENSMUST00000064405.2 ENSMUST00000064405.3 ENSMUST00000064405.4 ENSMUST00000064405.5 ENSMUST00000064405.6 ENSMUST00000064405.7 Epha3 NM_010140 Q8BRB1 Q8BRB1_MOUSE uc007zpy.1 uc007zpy.2 uc007zpy.3 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity GPI-linked ephrin receptor activity ATP binding early endosome integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of neuron projection development membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation regulation of actin cytoskeleton organization regulation of GTPase activity negative regulation of endocytosis ephrin receptor signaling pathway regulation of focal adhesion assembly regulation of microtubule cytoskeleton organization cellular response to retinoic acid positive regulation of protein localization to plasma membrane uc007zpy.1 uc007zpy.2 uc007zpy.3 
ENSMUST00000064433.11 Tmod2 ENSMUST00000064433.11 tropomodulin 2, transcript variant 2 (from RefSeq NM_016711.3) ENSMUST00000064433.1 ENSMUST00000064433.10 ENSMUST00000064433.2 ENSMUST00000064433.3 ENSMUST00000064433.4 ENSMUST00000064433.5 ENSMUST00000064433.6 ENSMUST00000064433.7 ENSMUST00000064433.8 ENSMUST00000064433.9 NM_016711 Q3UH50 Q8BGX9 Q9CUK4 Q9JKK7 Q9JLH9 TMOD2_MOUSE uc009qsm.1 uc009qsm.2 uc009qsm.3 uc009qsm.4 Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). Binds to the N-terminus of tropomyosin and to actin. Cytoplasm, cytoskeleton Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9JKK7-1; Sequence=Displayed; Name=2; IsoId=Q9JKK7-2; Sequence=VSP_024896, VSP_024897; Name=3; IsoId=Q9JKK7-3; Sequence=VSP_024895; Neuronal-tissue specific. Belongs to the tropomodulin family. actin binding tropomyosin binding cytoplasm cytoskeleton striated muscle thin filament muscle contraction neuron-neuron synaptic transmission learning or memory myofibril myofibril assembly growth cone neuron projection positive regulation of G-protein coupled receptor protein signaling pathway pointed-end actin filament capping uc009qsm.1 uc009qsm.2 uc009qsm.3 uc009qsm.4 
ENSMUST00000064444.8 Maneal ENSMUST00000064444.8 mannosidase, endo-alpha-like (from RefSeq NM_001007573.3) ENSMUST00000064444.1 ENSMUST00000064444.2 ENSMUST00000064444.3 ENSMUST00000064444.4 ENSMUST00000064444.5 ENSMUST00000064444.6 ENSMUST00000064444.7 Gm50 MANEL_MOUSE NM_001007573 Q3UVP2 Q6P1J0 uc008urg.1 uc008urg.2 Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the glycosyl hydrolase 99 family. Golgi membrane alpha-mannosidase activity Golgi apparatus biological_process membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds uc008urg.1 uc008urg.2 
ENSMUST00000064447.12 Nup188 ENSMUST00000064447.12 nucleoporin 188, transcript variant 2 (from RefSeq NR_156132.1) ENSMUST00000064447.1 ENSMUST00000064447.10 ENSMUST00000064447.11 ENSMUST00000064447.2 ENSMUST00000064447.3 ENSMUST00000064447.4 ENSMUST00000064447.5 ENSMUST00000064447.6 ENSMUST00000064447.7 ENSMUST00000064447.8 ENSMUST00000064447.9 Kiaa0169 NR_156132 NU188_MOUSE Q4VA15 Q6ZQH8 Q80UL4 Q8C7A1 Q8R3F1 uc008jcb.1 uc008jcb.2 uc008jcb.3 Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Required for proper protein transport into the nucleus. Part of the nuclear pore complex (NPC). Nucleus, nuclear pore complex Belongs to the Nup188 family. Sequence=AAH25526.1; Type=Erroneous initiation; Evidence=; Sequence=BAC97883.1; Type=Erroneous initiation; Evidence=; nucleus nuclear pore protein import into nucleus protein transport structural constituent of nuclear pore nuclear pore inner ring mRNA transport uc008jcb.1 uc008jcb.2 uc008jcb.3 
ENSMUST00000064454.12 Gcn1 ENSMUST00000064454.12 GCN1 activator of EIF2AK4 (from RefSeq NM_172719.2) B2RWW6 E9PVA8 ENSMUST00000064454.1 ENSMUST00000064454.10 ENSMUST00000064454.11 ENSMUST00000064454.2 ENSMUST00000064454.3 ENSMUST00000064454.4 ENSMUST00000064454.5 ENSMUST00000064454.6 ENSMUST00000064454.7 ENSMUST00000064454.8 ENSMUST00000064454.9 GCN1_MOUSE Gcn1 Gcn1l1 NM_172719 uc008zeg.1 uc008zeg.2 uc008zeg.3 Ribosome collision sensor that plays a key role in the RNF14- RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (By similarity). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (By similarity). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (PubMed:15937339, PubMed:24333428, PubMed:32324833). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF- 2-alpha/EIF2S1) (PubMed:24333428, PubMed:32324833). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR- specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:24333428, PubMed:32324833). Interacts with EIF2AK4/GCN2; this interaction stimulates the EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation (PubMed:24333428). Interacts with IMPACT; this prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity (PubMed:15937339, PubMed:22404850). Interacts with RNF14; interaction takes place following ribosome stalling and promotes recruitment of RNF14 (By similarity). Cytoplasm te=Associates with ribosomes in undifferentiated neuroblastoma cells and increases after neuronal differentiation (PubMed:23447528). Expressed in the hypothalamus, cortex and hippocampus (PubMed:15937339). The RWDBD (RWD-binding domain) region mediates binding to RWD domain-containing proteins, such as EIF2AK4/GCN2, IMPACT and RNF14. Perinatal lethality; mice die at the intermediate stage of embryonic development because of severe growth retardation (PubMed:32324833). Tamoxifen-inducible deletion in adult mice leads to transient body weight loss associated with decrease of fat and liver glycogen storage (PubMed:35328622). Belongs to the GCN1 family. protein binding cytoplasm cytosol polysome regulation of translation protein kinase regulator activity protein kinase binding positive regulation of kinase activity cellular response to amino acid starvation positive regulation of transcription from RNA polymerase II promoter in response to stress ribosome binding regulation of protein kinase activity cellular response to leucine starvation uc008zeg.1 uc008zeg.2 uc008zeg.3 
ENSMUST00000064462.5 C1ql4 ENSMUST00000064462.5 complement component 1, q subcomponent-like 4 (from RefSeq NM_001024702.1) B2RV40 C1QL4_MOUSE C1qtnf11 Ctrp11 ENSMUST00000064462.1 ENSMUST00000064462.2 ENSMUST00000064462.3 ENSMUST00000064462.4 NM_001024702 Q4ZJM9 uc007xot.1 uc007xot.2 uc007xot.3 May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. May inhibit adipocyte differentiation at an early stage of the process. Forms homooligomers, predominantly dimers or trimers. Forms heterooligomers with C1QL1, C1QL2 and C1QL3, when proteins are coexpressed; this interaction does not occur after secretion (PubMed:23449976). Interacts with ADGRB3 (PubMed:21262840). Secreted Highly expressed in testis and adipose tissue, brown adipose tissue expressing higher levels than subcutaneous and visceral white adipose tissue. In gonadal fat pad, expressed at lower levels in adipocytes than in the stromal vascular fraction (VSP), which contains preadipocytes, fibroblasts, endothelial cells and occasional immune cells. Expression exhibits sexually dimorphism, with higher levels in females than in males. Down-regulated in fasted animals. protein binding extracellular region collagen trimer extracellular space identical protein binding negative regulation of fat cell differentiation negative regulation of fibroblast proliferation negative regulation of ERK1 and ERK2 cascade uc007xot.1 uc007xot.2 uc007xot.3 
ENSMUST00000064473.13 Adarb2 ENSMUST00000064473.13 adenosine deaminase, RNA-specific, B2, transcript variant 1 (from RefSeq NM_052977.5) Adar3 ENSMUST00000064473.1 ENSMUST00000064473.10 ENSMUST00000064473.11 ENSMUST00000064473.12 ENSMUST00000064473.2 ENSMUST00000064473.3 ENSMUST00000064473.4 ENSMUST00000064473.5 ENSMUST00000064473.6 ENSMUST00000064473.7 ENSMUST00000064473.8 ENSMUST00000064473.9 NM_052977 Q3UTP1 Q8CC51 Q9JI20 Q9JIE5 RED2_MOUSE Red2 uc007pkf.1 uc007pkf.2 uc007pkf.3 uc007pkf.4 Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA (By similarity). Nucleus Brain specific. RNA binding double-stranded RNA binding double-stranded RNA adenosine deaminase activity adenosine deaminase activity nucleus nucleolus cytoplasm adenosine to inosine editing RNA processing mRNA processing tRNA-specific adenosine deaminase activity hydrolase activity metal ion binding uc007pkf.1 uc007pkf.2 uc007pkf.3 uc007pkf.4 
ENSMUST00000064475.4 Defb34 ENSMUST00000064475.4 defensin beta 34 (from RefSeq NM_183035.1) DFB34_MOUSE ENSMUST00000064475.1 ENSMUST00000064475.2 ENSMUST00000064475.3 NM_183035 Q7TNV8 uc009lad.1 uc009lad.2 Has antibacterial activity. Secreted Only expressed in epididymis (caput, corpus and cauda). Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium innate immune response uc009lad.1 uc009lad.2 
ENSMUST00000064476.5 Arl13a ENSMUST00000064476.5 ADP-ribosylation factor-like 13A (from RefSeq NM_028947.1) AR13A_MOUSE Arl13 ENSMUST00000064476.1 ENSMUST00000064476.2 ENSMUST00000064476.3 ENSMUST00000064476.4 NM_028947 Q497J4 Q9D416 uc009ufp.1 uc009ufp.2 uc009ufp.3 Belongs to the small GTPase superfamily. nucleotide binding GTP binding cilium ciliary membrane receptor localization to non-motile cilium non-motile cilium non-motile cilium assembly uc009ufp.1 uc009ufp.2 uc009ufp.3 
ENSMUST00000064488.11 Gan ENSMUST00000064488.11 giant axonal neuropathy (from RefSeq NM_001081151.2) ENSMUST00000064488.1 ENSMUST00000064488.10 ENSMUST00000064488.2 ENSMUST00000064488.3 ENSMUST00000064488.4 ENSMUST00000064488.5 ENSMUST00000064488.6 ENSMUST00000064488.7 ENSMUST00000064488.8 ENSMUST00000064488.9 GAN_MOUSE Gan NM_001081151 Q8CA72 uc009nox.1 uc009nox.2 Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB (By similarity). Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. Protein modification; protein ubiquitination. Interacts with TBCB. Interacts with CUL3. Part of a complex that contains CUL3, RBX1 and GAN. Interacts (via BTB domain) with UBA1 (By similarity). Interacts (via Kelch domains) with MAP1B (via C- terminus) and MAP1S (via C-terminus). Cytoplasm Cytoplasm, cytoskeleton Expressed in brain, heart and muscle (at protein level). Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Mice have a relatively normal life span. However, they display deterioration in motor function with onset varying from 6 to 10 months as well as abnormalities in non-neuronal tissues. The prominent pathological features include limb weakness, muscular atrophy, axonal degeneration, neurofilament accumulation, an abnormal microtubule network, mitochondrial swelling and thinned myelin sheaths. cytoplasm cytoskeleton cytoskeleton organization protein ubiquitination Cul3-RING ubiquitin ligase complex uc009nox.1 uc009nox.2 
ENSMUST00000064493.7 D930048N14Rik ENSMUST00000064493.7 RIKEN cDNA D930048N14 gene (from RefSeq NR_027958.1) ENSMUST00000064493.1 ENSMUST00000064493.2 ENSMUST00000064493.3 ENSMUST00000064493.4 ENSMUST00000064493.5 ENSMUST00000064493.6 NR_027958 uc007iuf.1 uc007iuf.2 uc007iuf.3 uc007iuf.4 uc007iuf.1 uc007iuf.2 uc007iuf.3 uc007iuf.4 
ENSMUST00000064495.8 Hook2 ENSMUST00000064495.8 hook microtubule tethering protein 2, transcript variant 12 (from RefSeq NR_164168.1) ENSMUST00000064495.1 ENSMUST00000064495.2 ENSMUST00000064495.3 ENSMUST00000064495.4 ENSMUST00000064495.5 ENSMUST00000064495.6 ENSMUST00000064495.7 HOOK2_MOUSE NR_164168 Q66JV2 Q7TMK6 Q8BY47 Q8R347 Q8VCN4 Q99LU2 uc009mor.1 uc009mor.2 uc009mor.3 uc009mor.4 Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. Self-associates (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3 (By similarity). May interact directly with AKTIP/FTS, HOOK1 and HOOK3 (By similarity). Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect (By similarity). Interacts with CNTRL (By similarity). Interacts with microtubules (By similarity). Interacts with ZC3H14 (By similarity). Interacts with LRGUK (via guanylate kinase-like domain) (PubMed:25781171, PubMed:28003339). Interacts with CCDC181 (PubMed:28283191). Interacts with AP4M1; the interaction is direct, mediates the interaction between FTS-Hook-FHIP (FHF) complex and AP-4 and the perinuclear distribution of AP-4 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome toplasm Cytoplasm, cytoskeleton lgi apparatus, trans-Golgi network Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosome, or mitochondria (By similarity). Often found in close association with microtubules (By similarity). Localizes to the manchette in elongating spermatids (PubMed:28003339). Expressed in brain, cerebellum, kidney, liver and heart, with highest levels in heart and kidney (at protein level). Belongs to the hook family. Sequence=AAH02226.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding cytoplasm centrosome microtubule organizing center cytosol cytoskeleton microtubule endosome organization lysosome organization microtubule binding endosome to lysosome transport protein transport cytoskeleton-dependent intracellular transport HOPS complex cytoplasmic microtubule organization identical protein binding intracellular membrane-bounded organelle early endosome to late endosome transport dynein light intermediate chain binding FHF complex uc009mor.1 uc009mor.2 uc009mor.3 uc009mor.4 
ENSMUST00000064503.13 Lnpk ENSMUST00000064503.13 lunapark, ER junction formation factor, transcript variant 1 (from RefSeq NM_027133.3) A2ASL9 ENSMUST00000064503.1 ENSMUST00000064503.10 ENSMUST00000064503.11 ENSMUST00000064503.12 ENSMUST00000064503.2 ENSMUST00000064503.3 ENSMUST00000064503.4 ENSMUST00000064503.5 ENSMUST00000064503.6 ENSMUST00000064503.7 ENSMUST00000064503.8 ENSMUST00000064503.9 Kiaa1715 LNP_MOUSE Lnp Lnpk NM_027133 Q69ZC5 Q6PAQ1 Q6PEN8 Q7TQ95 Uln uc008kdq.1 uc008kdq.2 uc008kdq.3 uc008kdq.4 Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network. May be involved in limb and central nervous system development (PubMed:12732147). Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner. Endoplasmic reticulum membrane ; Multi-pass membrane protein ; Cytoplasmic side Note=Localizes at endoplasmic reticulum (ER) three-way tubular junctions, which represent crossing-points at which the tubules build a polygonal network. Expressed in most tissues at basal level, with reinforcement in distal limb buds, genital bud, and in parts of the central nervous system. Strongly expressed in both limb and genital buds as is the case for Evx2 and Hoxd genes, in particular Hoxd13. In developing limb buds, it is first seen in 10.5 days old fetuses, in the posterior distal bud, to subsequently extend throughout the distal aspect, in presumptive digits. The transmembrane domain 1 and 2 function as a signal-anchor and stop-transfer sequence, respectively, generating a double-spanning integral membrane protein with a N- and C-terminal cytoplasmic orientation. Transmembrane domain 1 and 2 are probably sufficient to mediate membrane translocation and topology formation in a N- myristoylation-independent manner. Transmembrane domain 2 is sufficient to block the protein secretion pathway. The two coiled-coil domains are necessary for its endoplasmic reticulum (ER) three-way tubular junction localization. The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. Myristoylated; myristoylation is necessary for the endoplasmic reticulum (ER) three-way ER tubular junction formation, but is not required neither for membrane translocation, membrane topology formation, nor for the specific localization to ER membranes. Phosphorylated. Phosphorylation occurs at Ser-177, Ser-182, Ser- 222, Ser-316 and Ser-380 during interphase. Phosphorylation occurs at Ser-114, Ser-153, Ser-194, Thr-211 and Ser-348 during mitosis; these phosphorylations reduce both its homodimerization and the ER three-way tubular junction formation. Subject to proteasomal degradation following phosphorylation during mitosis. Was named 'Lunapark' because the protein sequence contains the word 'LNPARK'. Belongs to the lunapark family. Sequence=BAD32519.1; Type=Erroneous initiation; Evidence=; Sequence=BC060153; Type=Frameshift; Evidence=; nucleoplasm endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum organization multicellular organism development blood coagulation membrane integral component of membrane integral component of endoplasmic reticulum membrane regulation of chondrocyte differentiation embryonic forelimb morphogenesis embryonic digit morphogenesis identical protein binding metal ion binding endoplasmic reticulum tubular network endoplasmic reticulum tubular network organization endoplasmic reticulum tubular network maintenance endoplasmic reticulum tubular network membrane positive regulation of endoplasmic reticulum tubular network organization uc008kdq.1 uc008kdq.2 uc008kdq.3 uc008kdq.4 
ENSMUST00000064517.9 Serp2 ENSMUST00000064517.9 stress-associated endoplasmic reticulum protein family member 2, transcript variant 6 (from RefSeq NR_153389.1) ENSMUST00000064517.1 ENSMUST00000064517.2 ENSMUST00000064517.3 ENSMUST00000064517.4 ENSMUST00000064517.5 ENSMUST00000064517.6 ENSMUST00000064517.7 ENSMUST00000064517.8 NR_153389 Q497L0 Q6TAW2 SERP2_MOUSE uc011zor.1 uc011zor.2 uc011zor.3 Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins. Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX. Membrane ; Single- pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6TAW2-1; Sequence=Displayed; Name=2; IsoId=Q6TAW2-2; Sequence=VSP_022876, VSP_022877; Belongs to the RAMP4 family. molecular_function endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation protein transport membrane integral component of membrane endoplasmic reticulum unfolded protein response uc011zor.1 uc011zor.2 uc011zor.3 
ENSMUST00000064536.13 Adam17 ENSMUST00000064536.13 a disintegrin and metallopeptidase domain 17, transcript variant 1 (from RefSeq NM_009615.6) ADA17_MOUSE ENSMUST00000064536.1 ENSMUST00000064536.10 ENSMUST00000064536.11 ENSMUST00000064536.12 ENSMUST00000064536.2 ENSMUST00000064536.3 ENSMUST00000064536.4 ENSMUST00000064536.5 ENSMUST00000064536.6 ENSMUST00000064536.7 ENSMUST00000064536.8 ENSMUST00000064536.9 NM_009615 O88726 Q505A7 Q9R1U4 Q9Z0F8 Q9Z0K3 Tace uc007ndu.1 uc007ndu.2 uc007ndu.3 uc007ndu.4 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero or fail to survive beyond one week of age. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]. Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2 (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:10799547, PubMed:11108241). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT) (PubMed:10882063). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (PubMed:12907434). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (PubMed:17245433). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (By similarity). Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. Reaction=Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln- Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane- anchored, cell-surface proteins to 'shed' the extracellular domains.; EC=3.4.24.86; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Inhibited by metalloproteinase inhibitor 3 (TIMP- 3), but not by TIMP-1, TIMP-2 and TIMP-4. Interacts with MAD2L1, MAPK14 and MUC1. Interacts with iRhom1/RHBDF1 and iRhom2/RHBDF2. Interacts with FRMD8 via its interaction with iRhom1/RHBDF1 and iRhom2/RHBDF2. Q9Z0F8; Q80WQ6: Rhbdf2; NbExp=6; IntAct=EBI-7848498, EBI-647271; [Isoform Long]: Cell membrane; Single-pass type I membrane protein. [Isoform Short]: Secreted. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q9Z0F8-1; Sequence=Displayed; Name=Short; IsoId=Q9Z0F8-2; Sequence=VSP_005479, VSP_005480; Ubiquitously expressed. Expressed at highest levels in heart, liver, skeletal muscle, kidney and testes. Expressed at lower levels in brain, spleen and lung. Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Phosphorylated. Stimulation by growth factor or phorbol 12- myristate 13-acetate induces phosphorylation of Ser-822 but decreases phosphorylation of Ser-794. Phosphorylation at Thr-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding (By similarity). response to hypoxia positive regulation of protein phosphorylation germinal center formation production of molecular mediator involved in inflammatory response endopeptidase activity metalloendopeptidase activity serine-type endopeptidase activity Notch binding interleukin-6 receptor binding integrin binding protein binding extracellular region extracellular space cytoplasm cytosol plasma membrane integral component of plasma membrane proteolysis membrane protein ectodomain proteolysis cell adhesion epidermal growth factor receptor signaling pathway Notch signaling pathway Notch receptor processing peptidase activity metallopeptidase activity positive regulation of cell proliferation cell surface positive regulation of T cell chemotaxis positive regulation of neuron projection development negative regulation of neuron projection development actin cytoskeleton membrane integral component of membrane apical plasma membrane hydrolase activity SH3 domain binding PDZ domain binding B cell differentiation positive regulation of cell growth positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway cytoplasmic vesicle response to lipopolysaccharide positive regulation of chemokine production regulation of mast cell apoptotic process T cell differentiation in thymus cell adhesion mediated by integrin receptor transactivation response to drug positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of blood vessel endothelial cell migration membrane raft apical part of cell positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of epidermal growth factor-activated receptor activity metal ion binding spleen development regulation of axon regeneration cell motility defense response to Gram-positive bacterium PMA-inducible membrane protein ectodomain proteolysis positive regulation of cellular component movement positive regulation of ERK1 and ERK2 cascade cellular response to high density lipoprotein particle stimulus positive regulation of G1/S transition of mitotic cell cycle positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of vascular endothelial cell proliferation regulation of neuron migration cell-cell junction focal adhesion ruffle membrane uc007ndu.1 uc007ndu.2 uc007ndu.3 uc007ndu.4 
ENSMUST00000064571.11 Afap1 ENSMUST00000064571.11 actin filament associated protein 1, transcript variant 2 (from RefSeq NM_027373.3) AFAP1_MOUSE ENSMUST00000064571.1 ENSMUST00000064571.10 ENSMUST00000064571.2 ENSMUST00000064571.3 ENSMUST00000064571.4 ENSMUST00000064571.5 ENSMUST00000064571.6 ENSMUST00000064571.7 ENSMUST00000064571.8 ENSMUST00000064571.9 Kiaa3018 NM_027373 Q3UGX1 Q6ZPE4 Q80YS6 uc008xej.1 uc008xej.2 uc008xej.3 Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton (By similarity). Monomer and homomultimer. Interacts via its C-terminus with F- actin; probably involving AFAP1 multimers. Interacts with activated SRC SH3-SH2 domains. Interacts via its PH 1 domain with PRKCA, PRKCB and PRKCI (By similarity). Cytoplasm, cytoskeleton, stress fiber Phosphorylated on tyrosine residues by SRC. Sequence=BAC98293.1; Type=Erroneous initiation; Evidence=; actin binding cytoplasm cytosol cytoskeleton actin filament focal adhesion regulation of signal transduction actin cytoskeleton SH3 domain binding SH2 domain binding regulation of cytoskeleton organization uc008xej.1 uc008xej.2 uc008xej.3 
ENSMUST00000064576.8 Terb1 ENSMUST00000064576.8 telomere repeat binding bouquet formation protein 1 (from RefSeq NM_180958.3) A1L2Z9 Ccdc79 E9QPF2 ENSMUST00000064576.1 ENSMUST00000064576.2 ENSMUST00000064576.3 ENSMUST00000064576.4 ENSMUST00000064576.5 ENSMUST00000064576.6 ENSMUST00000064576.7 NM_180958 Q14CI1 Q8C0N5 Q8C0V1 TERB1_MOUSE Terb1 uc009naq.1 uc009naq.2 Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis (PubMed:24885367, PubMed:24413433, PubMed:26548954). Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN- TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA (PubMed:26548954). In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment' (PubMed:26548954). Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex (PubMed:24885367, PubMed:24413433). Also recruits cohesin to telomeres to develop structural rigidity (PubMed:24413433). Component of the MAJIN-TERB1-TERB2 complex, composed of MAJIN, TERB1 and TERB2 (PubMed:26548954). Interacts with TERF1, STAG3 and SUN1 (PubMed:24413433). Interacts (via Myb-like domain) with the cohesin complex; probably mediated via interaction with STAG3 (PubMed:24413433). Q8C0V1; Q9D666: Sun1; NbExp=2; IntAct=EBI-11707325, EBI-6752574; Q8C0V1-1; P70371: Terf1; NbExp=4; IntAct=EBI-16089839, EBI-6919183; Chromosome, telomere Nucleus inner membrane Note=Localizes to telomeres during meiotic prophase (PubMed:24413433). In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane (PubMed:26548954). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8C0V1-1; Sequence=Displayed; Name=2; IsoId=Q8C0V1-2; Sequence=VSP_031617, VSP_031623; Name=3; IsoId=Q8C0V1-3; Sequence=VSP_031616, VSP_031618, VSP_031620, VSP_031622; Name=4; IsoId=Q8C0V1-4; Sequence=VSP_031616, VSP_031618, VSP_031619, VSP_031621; Expressed in testis and fetal oocytes. Expressed during meiotic prophase and becomes undetectable in metaphase I in spermatocytes and oocytes (at protein level). Phosphorylated by CDK (PubMed:24413433, PubMed:26548954). Phosphorylation by CDK takes place in late prophase when the cap exchange is prominent (PubMed:26548954). is important for the stabilization of telomere attachment but dispenable for the cap exchange (PubMed:26548954). Mice develop normally, exhibit no overt phenotype, but are infertile (both males and females). Testis lack postmeiotic cells due to massive elimination of spermatocytes, while females show degeneration of the ovaries, lacking growing follicles and mature oocytes. Belongs to the TERB1 family. chromosome, telomeric region nuclear chromosome, telomeric region DNA binding protein binding nucleus nuclear inner membrane chromosome synapsis membrane meiotic telomere clustering meiotic cell cycle meiotic attachment of telomere to nuclear envelope telosome uc009naq.1 uc009naq.2 
ENSMUST00000064580.14 Slc6a13 ENSMUST00000064580.14 solute carrier family 6 (neurotransmitter transporter, GABA), member 13, transcript variant 8 (from RefSeq NR_176896.1) ENSMUST00000064580.1 ENSMUST00000064580.10 ENSMUST00000064580.11 ENSMUST00000064580.12 ENSMUST00000064580.13 ENSMUST00000064580.2 ENSMUST00000064580.3 ENSMUST00000064580.4 ENSMUST00000064580.5 ENSMUST00000064580.6 ENSMUST00000064580.7 ENSMUST00000064580.8 ENSMUST00000064580.9 Gabt2 Gabt3 Gat-3 Gat2 Gat3 NR_176896 P31649 S6A13_MOUSE uc009doj.1 uc009doj.2 uc009doj.3 Mediates sodium- and chloride-dependent transport of gamma- aminobutyric acid (GABA) (PubMed:8420981, PubMed:22896705, PubMed:30270321). Can also mediate transport of beta-alanine, taurine and hypotaurine and is the major taurine transporter in hepatocytes (PubMed:8420981, PubMed:22896705, PubMed:30270321). Reaction=4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) = 4- aminobutanoate(in) + chloride(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70687, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:59888; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70688; Evidence=; Reaction=chloride(out) + 2 Na(+)(out) + taurine(out) = chloride(in) + 2 Na(+)(in) + taurine(in); Xref=Rhea:RHEA:71223, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:507393; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71224; Evidence=; Reaction=beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta- alanine(in) + chloride(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71247, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57966; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71248; Evidence=; Reaction=chloride(out) + hypotaurine(out) + 2 Na(+)(out) = chloride(in) + hypotaurine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71243, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57853; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71244; Evidence=; Gamma-aminobutyric acid (GABA) transport is inhibited by beta-alanine, taurine, hypotaurine, beta- guanidinopropionic acid, 2,3-diaminopropionic acid, guvacine and nipecotic acid (PubMed:8420981, PubMed:22896705). Beta-alanine transport is inhibited by GABA (PubMed:8420981). Taurine transport is inhibited by GABA, beta-alanine, SNAP-5114, nigericin, nipecotic acid and ouabain (PubMed:22896705). Kinetic parameters: KM=18 uM for GABA ; KM=28 uM for beta-alanine ; KM=540 uM for taurine ; KM=210 uM for taurine ; KM=10.6 uM for hypotaurine ; Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Note=In the kidney, detected at the basolateral membranes of parts of proximal tubules. Expressed at high levels in liver, followed by kidney and leptomeninges, and very low levels in the cerebellum (at protein level). In the brain, detected in some blood vessels (at protein level). In the kidney, expressed in the cortex, including parts of the proximal tubules, but not in the medulla (at protein level). In the liver, highest expression in periportal hepatocytes, with highest density at the vascular side (at protein level). Also detected at low levels in other organs, including skeletal muscle. Abundant in neonatal brain, but not in adult brain. Mutant animals are born at the expected Mendelian ratio. They appear normal, fertile, with a normal life span. Tissue taurine levels are altered, with 50% decrease in the liver and 20% increase in the brain. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily. neurotransmitter:sodium symporter activity gamma-aminobutyric acid:sodium symporter activity plasma membrane integral component of plasma membrane neurotransmitter transport symporter activity gamma-aminobutyric acid transport membrane integral component of membrane neurotransmitter binding neuron projection transmembrane transport uc009doj.1 uc009doj.2 uc009doj.3 
ENSMUST00000064606.8 Lrrc15 ENSMUST00000064606.8 leucine rich repeat containing 15 (from RefSeq NM_028973.2) ENSMUST00000064606.1 ENSMUST00000064606.2 ENSMUST00000064606.3 ENSMUST00000064606.4 ENSMUST00000064606.5 ENSMUST00000064606.6 ENSMUST00000064606.7 LRC15_MOUSE NM_028973 Q80X72 uc007ywn.1 uc007ywn.2 uc007ywn.3 uc007ywn.4 Cell membrane ; Single-pass type I membrane protein Expressed in chodrocytes (at protein level). In chodrocytes, expression is induced by IL1B. fibronectin binding collagen binding extracellular space cell surface membrane integral component of membrane positive regulation of cell migration extracellular matrix laminin binding receptor-mediated virion attachment to host cell negative regulation of protein localization to plasma membrane uc007ywn.1 uc007ywn.2 uc007ywn.3 uc007ywn.4 
ENSMUST00000064614.4 Lypd9 ENSMUST00000064614.4 LY6/PLAUR domain containing 9 (from RefSeq NM_207527.3) 4930504O13Rik ENSMUST00000064614.1 ENSMUST00000064614.2 ENSMUST00000064614.3 Lypd9 NM_207527 Q8C5Z9 Q8C5Z9_MOUSE uc007jbn.1 uc007jbn.2 uc007jbn.3 uc007jbn.4 molecular_function cellular_component biological_process uc007jbn.1 uc007jbn.2 uc007jbn.3 uc007jbn.4 
ENSMUST00000064635.12 Eef2kmt ENSMUST00000064635.12 eukaryotic elongation factor 2 lysine methyltransferase (from RefSeq NM_027446.2) EF2KT_MOUSE ENSMUST00000064635.1 ENSMUST00000064635.10 ENSMUST00000064635.11 ENSMUST00000064635.2 ENSMUST00000064635.3 ENSMUST00000064635.4 ENSMUST00000064635.5 ENSMUST00000064635.6 ENSMUST00000064635.7 ENSMUST00000064635.8 ENSMUST00000064635.9 Fam86 Fam86a NM_027446 Q3TQL2 Q3UZW7 Q80XE2 Q9CS89 uc007ybz.1 uc007ybz.2 uc007ybz.3 Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'. Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54193; Evidence=; Interacts with FAM86B2 and FAM86C1P. Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UZW7-1; Sequence=Displayed; Name=2; IsoId=Q3UZW7-2; Sequence=VSP_033329; Name=3; IsoId=Q3UZW7-3; Sequence=VSP_033330; Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family. cytoplasm methyltransferase activity protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine trimethylation methylation macromolecular complex uc007ybz.1 uc007ybz.2 uc007ybz.3 
ENSMUST00000064637.11 Rnf103 ENSMUST00000064637.11 ring finger protein 103, transcript variant 1 (from RefSeq NM_009543.4) B9EHC2 ENSMUST00000064637.1 ENSMUST00000064637.10 ENSMUST00000064637.2 ENSMUST00000064637.3 ENSMUST00000064637.4 ENSMUST00000064637.5 ENSMUST00000064637.6 ENSMUST00000064637.7 ENSMUST00000064637.8 ENSMUST00000064637.9 NM_009543 O08670 O08883 Q9R1W3 RN103_MOUSE Zfp103 uc009cgv.1 uc009cgv.2 uc009cgv.3 uc009cgv.4 This gene encodes a member of the RING finger family of E3 ubiquitin-protein ligases. These proteins catalyze the transfer of the ubiquitin protein from a ubiquitin E2 enzyme to a protein substrate. Homozygous knockout mice for this gene exhibit enhanced anxiety-like behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with DERL1 and VCP. Endoplasmic reticulum membrane ; Multi-pass membrane protein Highly expressed in the normal cerebellum but not in the cerebral cortex. ubiquitin-protein transferase activity endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane protein ubiquitination transferase activity ER-associated ubiquitin-dependent protein catabolic process metal ion binding uc009cgv.1 uc009cgv.2 uc009cgv.3 uc009cgv.4 
ENSMUST00000064656.8 Zfp365 ENSMUST00000064656.8 zinc finger protein 365 (from RefSeq NM_178679.2) Dbz ENSMUST00000064656.1 ENSMUST00000064656.2 ENSMUST00000064656.3 ENSMUST00000064656.4 ENSMUST00000064656.5 ENSMUST00000064656.6 ENSMUST00000064656.7 Kiaa0844 NM_178679 Q80TQ4 Q8BG89 Q8BK39 Q8BXT2 ZN365_MOUSE Znf365 uc007fmb.1 uc007fmb.2 uc007fmb.3 Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis (PubMed:23912123). Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth (PubMed:24481677). Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (PubMed:25983680). Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth. Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (By similarity). Homodimer. Interacts with NDE1 and NDEL1 (By similarity). Interacts with DISC1. Interacts with PARP1 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=ZNF365a; IsoId=Q8BG89-1; Sequence=Displayed; Name=2; IsoId=Q8BG89-2; Sequence=VSP_016601, VSP_016602; Detected in several tissues, with highest levels in brain. Also expressed during embryonic development. Expressed in cerebral cortex, hippocampus, striatum, inferior colliculus and thalamus (PubMed:23912123). In the embryo at day 14.5 post-coitum, expressed in the basal, medial and lateral ganglionic eminences of the cerebral cortex, but not in the caudal ganglionic eminence (PubMed:23912123). Expressed in the corpus callosum from postnatal day 7 (PD7) to PD56 with a peak at PD14 (PubMed:24481677). Induced by gamma irradiation. Basket cells with reduced branches and short processes in the somatosensory cortex of adult knockout (KO) mice. Reduced expression of the gamma-aminobutyric acid-synthesizing enzymes Gad1 in the somatosensory cortex of KO mice (PubMed:23912123). Delayed myelination in the corpus callosum of KO mice during the postnatal period, but recovery by adulthood (PubMed:24481677). Decreased dendritic arborization and increased spine density dendrites in cortical pyramidal neurons of adult KO mice (PubMed:25983680). Sequence=BAC65669.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; mitotic cytokinesis telomere maintenance cytoplasm centrosome microtubule organizing center cytoskeleton nervous system development regulation of double-strand break repair via homologous recombination negative regulation of neuron projection development cerebellar molecular layer morphogenesis gamma-tubulin complex localization identical protein binding protein homodimerization activity intracellular membrane-bounded organelle metal ion binding positive regulation of oligodendrocyte differentiation dendritic spine morphogenesis gamma-tubulin complex uc007fmb.1 uc007fmb.2 uc007fmb.3 
ENSMUST00000064659.6 Zmat1 ENSMUST00000064659.6 zinc finger, matrin type 1 (from RefSeq NM_175446.3) ENSMUST00000064659.1 ENSMUST00000064659.2 ENSMUST00000064659.3 ENSMUST00000064659.4 ENSMUST00000064659.5 G5E8E4 G5E8E4_MOUSE NM_175446 Zmat1 uc009ugy.1 uc009ugy.2 uc009ugy.3 uc009ugy.4 nucleic acid binding zinc ion binding metal ion binding uc009ugy.1 uc009ugy.2 uc009ugy.3 uc009ugy.4 
ENSMUST00000064667.9 Rap1b ENSMUST00000064667.9 RAS related protein 1b (from RefSeq NM_024457.2) ENSMUST00000064667.1 ENSMUST00000064667.2 ENSMUST00000064667.3 ENSMUST00000064667.4 ENSMUST00000064667.5 ENSMUST00000064667.6 ENSMUST00000064667.7 ENSMUST00000064667.8 NM_024457 Q99JI6 RAP1B_MOUSE uc007hdr.1 uc007hdr.2 uc007hdr.3 GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner. Heterodimer with RAP1GAP (By similarity). Interacts with EPAC2 (By similarity). Interacts with SGSM1 (By similarity). Interacts with SGSM2 (By similarity). Interacts with SGSM3 (By similarity). Interacts with KRIT1 (By similarity). Interacts with RAP1GDS1 (By similarity). Cell membrane Cytoplasm, cytosol Cell junction Note=May shuttle between plasma membrane and cytosol (By similarity). Presence of KRIT1 and CDH5 is required for its localization to the cell junction (By similarity). Belongs to the small GTPase superfamily. Ras family. nucleotide binding GTPase activity protein binding GTP binding cytoplasm lipid particle cytosol plasma membrane cell-cell junction signal transduction small GTPase mediated signal transduction cell proliferation response to carbohydrate membrane GDP binding cell junction Rap protein signal transduction positive regulation of integrin activation cellular response to drug macromolecular complex binding negative regulation of calcium ion-dependent exocytosis establishment of endothelial barrier positive regulation of ERK1 and ERK2 cascade cellular response to cAMP cellular response to organic cyclic compound cellular response to gonadotropin-releasing hormone regulation of cell junction assembly regulation of establishment of cell polarity negative regulation of synaptic vesicle exocytosis uc007hdr.1 uc007hdr.2 uc007hdr.3 
ENSMUST00000064679.9 Rab7b ENSMUST00000064679.9 RAB7B, member RAS oncogene family, transcript variant 1 (from RefSeq NM_145509.3) ENSMUST00000064679.1 ENSMUST00000064679.2 ENSMUST00000064679.3 ENSMUST00000064679.4 ENSMUST00000064679.5 ENSMUST00000064679.6 ENSMUST00000064679.7 ENSMUST00000064679.8 NM_145509 Q0PD09 Q8BJT0 Q8BZB1 Q8VEA8 RAB7B_MOUSE uc007cnp.1 uc007cnp.2 uc007cnp.3 Controls vesicular trafficking from endosomes to the trans- Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. Late endosome Lysosome Golgi apparatus Golgi apparatus, trans- Golgi network Cytoplasmic vesicle, phagosome Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side Note=Recruited to phagosomes containing S.aureus or Mycobacterium. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VEA8-1; Sequence=Displayed; Name=2; IsoId=Q8VEA8-2; Sequence=VSP_011108; Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity GTP binding lysosome endosome late endosome Golgi apparatus trans-Golgi network intracellular protein transport endosome to lysosome transport protein transport membrane phagocytic vesicle membrane cytoplasmic vesicle Rab protein signal transduction positive regulation of interleukin-6 production negative regulation of toll-like receptor 4 signaling pathway negative regulation of toll-like receptor 9 signaling pathway late endosome to Golgi transport phagocytic vesicle positive regulation of megakaryocyte differentiation positive regulation of NF-kappaB transcription factor activity cellular response to interferon-gamma phagosome-lysosome fusion uc007cnp.1 uc007cnp.2 uc007cnp.3 
ENSMUST00000064685.14 Meig1 ENSMUST00000064685.14 meiosis expressed gene 1, transcript variant 2 (from RefSeq NM_008579.4) ENSMUST00000064685.1 ENSMUST00000064685.10 ENSMUST00000064685.11 ENSMUST00000064685.12 ENSMUST00000064685.13 ENSMUST00000064685.2 ENSMUST00000064685.3 ENSMUST00000064685.4 ENSMUST00000064685.5 ENSMUST00000064685.6 ENSMUST00000064685.7 ENSMUST00000064685.8 ENSMUST00000064685.9 MEIG1_MOUSE MLZ-278 Meg1 Meig1 NM_008579 Q61845 uc008idx.1 uc008idx.2 Essential for spermiogenesis. Interacts with PACRG. Interacts with MORN3 (PubMed:25248657). Q61845; Q9DAK2: Pacrg; NbExp=3; IntAct=EBI-15805257, EBI-8572392; Expressed in the testes (at protein level) (PubMed:1390336, PubMed:35547804, PubMed:20339383). Expressed in the ovary (PubMed:20339383). Several isoforms have been identified differing in their 5'-untranslated exons. These isoforms show different tissue expression (PubMed:19805151). Some are expressed in various tissues, including lung, liver, brain, testis, oviduct and oocytes (PubMed:19805151). Some are testis-specific (PubMed:19805151). Detected in the fetal ovary and testis (PubMed:20339383). Detected in the testes as early as 6 days after birth, expression increases during the first wave of spermatogenesis (PubMed:19805151). Mice are viable, but males are sterile, producing only a few sperm that are morphologically abnormal. Spermatogenesis is dramatically impaired at the stage of elongation and condensation. Spermatozoa exhibit failure of flagellar formation, disorganization of sperm axonemes and deformed heads. Belongs to the MEIG1 family. protein binding nucleus spermatogenesis cell differentiation meiotic cell cycle uc008idx.1 uc008idx.2 
ENSMUST00000064701.8 B4galt7 ENSMUST00000064701.8 beta-1,4-galactosyltransferase 7, transcript variant 1 (from RefSeq NM_146045.2) B4GT7_MOUSE ENSMUST00000064701.1 ENSMUST00000064701.2 ENSMUST00000064701.3 ENSMUST00000064701.4 ENSMUST00000064701.5 ENSMUST00000064701.6 ENSMUST00000064701.7 NM_146045 Q7TNU3 Q8R087 Xgalt1 uc007qru.1 uc007qru.2 uc007qru.3 uc007qru.4 Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts. Reaction=3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:15297, Rhea:RHEA-COMP:12567, Rhea:RHEA- COMP:12570, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:132085, ChEBI:CHEBI:132088; EC=2.4.1.133; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Note=Cis cisternae of Golgi stack. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R087-1; Sequence=Displayed; Name=2; IsoId=Q8R087-2; Sequence=VSP_014231; Belongs to the glycosyltransferase 7 family. Name=Functional Glycomics Gateway - GTase; Note=b4GalT7; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_466"; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity Golgi apparatus carbohydrate metabolic process glycosaminoglycan biosynthetic process proteoglycan metabolic process protein glycosylation protein N-linked glycosylation galactosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups manganese ion binding Golgi cisterna membrane xylosylprotein 4-beta-galactosyltransferase activity metal ion binding negative regulation of fibroblast proliferation supramolecular fiber organization uc007qru.1 uc007qru.2 uc007qru.3 uc007qru.4 
ENSMUST00000064725.11 Serpinc1 ENSMUST00000064725.11 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1, transcript variant 1 (from RefSeq NM_080844.5) AT3 ENSMUST00000064725.1 ENSMUST00000064725.10 ENSMUST00000064725.2 ENSMUST00000064725.3 ENSMUST00000064725.4 ENSMUST00000064725.5 ENSMUST00000064725.6 ENSMUST00000064725.7 ENSMUST00000064725.8 ENSMUST00000064725.9 NM_080844 Q543J5 Q543J5_MOUSE Serpinc1 uc007dem.1 uc007dem.2 uc007dem.3 uc007dem.4 uc007dem.5 Forms protease inhibiting heterodimer with TMPRSS7. Secreted, extracellular space Belongs to the serpin family. protease binding acute inflammatory response to antigenic stimulus serine-type endopeptidase inhibitor activity extracellular space response to nutrient lactation heparin binding negative regulation of endopeptidase activity regulation of blood coagulation identical protein binding regulation of blood coagulation, intrinsic pathway uc007dem.1 uc007dem.2 uc007dem.3 uc007dem.4 uc007dem.5 
ENSMUST00000064740.9 Suclg1 ENSMUST00000064740.9 succinate-CoA ligase, GDP-forming, alpha subunit (from RefSeq NM_019879.3) ENSMUST00000064740.1 ENSMUST00000064740.2 ENSMUST00000064740.3 ENSMUST00000064740.4 ENSMUST00000064740.5 ENSMUST00000064740.6 ENSMUST00000064740.7 ENSMUST00000064740.8 NM_019879 Q8C2C3 Q9DBA3 Q9DCI8 Q9WUM5 SUCA_MOUSE Suclg1 uc009cjm.1 uc009cjm.2 uc009cjm.3 uc009cjm.4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. Reaction=ATP + CoA + succinate = ADP + phosphate + succinyl-CoA; Xref=Rhea:RHEA:17661, ChEBI:CHEBI:30031, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:456216; EC=6.2.1.5; Evidence= Reaction=CoA + GTP + succinate = GDP + phosphate + succinyl-CoA; Xref=Rhea:RHEA:22120, ChEBI:CHEBI:30031, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:58189; EC=6.2.1.4; Evidence= Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP- specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS). Mitochondrion Belongs to the succinate/malate CoA ligase alpha subunit family. Sequence=AAD33927.2; Type=Erroneous initiation; Evidence=; Sequence=AAH11087.1; Type=Erroneous initiation; Evidence=; Sequence=BAB22331.1; Type=Erroneous initiation; Evidence=; Sequence=BAB23804.1; Type=Erroneous initiation; Evidence=; Sequence=BAC40634.1; Type=Erroneous initiation; Evidence=; nucleotide binding catalytic activity nucleoside diphosphate kinase activity succinate-CoA ligase activity succinate-CoA ligase (ADP-forming) activity succinate-CoA ligase (GDP-forming) activity mitochondrion mitochondrial inner membrane cytosol plasma membrane tricarboxylic acid cycle succinyl-CoA metabolic process succinate metabolic process nucleoside diphosphate phosphorylation nucleoside triphosphate biosynthetic process ligase activity GDP binding macromolecular complex succinate-CoA ligase complex (GDP-forming) protein heterodimerization activity cofactor binding uc009cjm.1 uc009cjm.2 uc009cjm.3 uc009cjm.4 
ENSMUST00000064759.7 Strip1 ENSMUST00000064759.7 striatin interacting protein 1 (from RefSeq NM_153563.3) ENSMUST00000064759.1 ENSMUST00000064759.2 ENSMUST00000064759.3 ENSMUST00000064759.4 ENSMUST00000064759.5 ENSMUST00000064759.6 Fam40a Kiaa1761 NM_153563 Q80T92 Q8BZC6 Q8C079 Q8CIF7 STRP1_MOUSE uc008qxg.1 uc008qxg.2 uc008qxg.3 uc008qxg.4 Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (By similarity). Component of striatin-interacting phosphatase and kinase (STRIPAK) complex (PubMed:18782753). Interacts with CDC42BPB. Interacts with CTTNBP2NL. Cytoplasm Note=Enriched on the plasma membrane. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8C079-1; Sequence=Displayed; Name=2; IsoId=Q8C079-2; Sequence=VSP_014865; Name=3; IsoId=Q8C079-3; Sequence=VSP_014866; Name=4; IsoId=Q8C079-4; Sequence=VSP_014863; Belongs to the STRIP family. [Isoform 2]: Sequence=BAC29206.1; Type=Frameshift; Evidence=; nucleus cytoplasm cytosol Rho GTPase binding protein kinase binding regulation of cell morphogenesis cortical actin cytoskeleton organization uc008qxg.1 uc008qxg.2 uc008qxg.3 uc008qxg.4 
ENSMUST00000064762.6 Map1b ENSMUST00000064762.6 microtubule-associated protein 1B (from RefSeq NM_008634.2) E9QM11 ENSMUST00000064762.1 ENSMUST00000064762.2 ENSMUST00000064762.3 ENSMUST00000064762.4 ENSMUST00000064762.5 MAP1B_MOUSE Mtap1b Mtap5 NM_008634 P14873 uc007rpr.1 uc007rpr.2 uc007rpr.3 uc007rpr.4 Required for proper microtubule dynamics. Plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation. 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino-terminal region of MAP1B. Interacts with ANP32A and TIAM2 (PubMed:12807913, PubMed:17320046). Interacts with the tubulin tyrosine TTL (PubMed:18075266). Interacts (via C-terminus) with GAN (via Kelch domains) (PubMed:12147674). Interacts (via N-terminus) with DAPK1 (By similarity). Interacts with TMEM185A (By similarity). Interacts with MAP1LC3B (By similarity). Interacts with KIRREL3 (By similarity). MAP1 light chain LC1 (via C-terminus): Interacts with ELAVL4; the interaction contributes to the association of ELAVL4 with microtubules (PubMed:21288476). MAP1 light chain LC1: Interacts with ELAVL2 and ELAVL3 (PubMed:21288476). P14873; Q61166: Mapre1; NbExp=5; IntAct=EBI-764653, EBI-2027055; P14873; Q9WTU3: Scn8a; NbExp=7; IntAct=EBI-764653, EBI-6396042; P14873; Q9UPY8: MAPRE3; Xeno; NbExp=4; IntAct=EBI-764653, EBI-726739; Cytoplasm, cytoskeleton Cytoplasm Synapse Cell projection, dendritic spine Note=Colocalizes with DAPK1 in the microtubules and cortical actin fibers. [MAP1 light chain LC1]: Cytoplasm Highly expressed in brain and cochlea, mildly expressed in heart, and very weakly expressed in liver and muscle. In the cochlea, it is abundantly expressed in spiral ganglions. Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1B to microtubules. LC1 is coexpressed with MAP1B. It is a polypeptide generated from MAP1B by proteolytic processing. It is free to associate with both MAP1A and MAP1B. It interacts with the N-terminal region of MAP1B. S-nitrosylation at Cys-2460 enhances interaction with microtubules, and may act as an effector modification for neuronal nitric oxide synthase control of growth-cone size, growth-cone collapse and axon retraction. Belongs to the MAP1 family. microtubule cytoskeleton organization microtubule bundle formation photoreceptor outer segment actin binding protein binding cytoskeletal regulatory protein binding phospholipid binding cytoplasm cytosol cytoskeleton microtubule microtubule associated complex plasma membrane microtubule-based process negative regulation of microtubule depolymerization nervous system development axonogenesis synapse assembly microtubule binding response to wounding response to mechanical stimulus response to carbohydrate cellular process response to inorganic substance peripheral nervous system axon regeneration postsynaptic density tubulin binding dendrite development response to insecticide developmental maturation cell junction axon dendrite growth cone regulation of microtubule depolymerization positive regulation of microtubule polymerization response to nutrient levels response to estradiol negative regulation of intracellular transport response to vitamin A somatodendritic compartment response to drug cell projection neuronal cell body varicosity dendritic spine perikaryon macromolecular complex binding synapse positive regulation of neuron differentiation positive regulation of axon extension mitochondrion transport along microtubule perinuclear region of cytoplasm neuron development axon extension response to axon injury induction of synaptic plasticity by chemical substance establishment of monopolar cell polarity cellular response to growth factor stimulus cellular response to peptide hormone stimulus apical dendrite basilar dendrite hippocampal mossy fiber uc007rpr.1 uc007rpr.2 uc007rpr.3 uc007rpr.4 
ENSMUST00000064763.7 Zfp608 ENSMUST00000064763.7 zinc finger protein 608, transcript variant 1 (from RefSeq NM_175751.4) ENSMUST00000064763.1 ENSMUST00000064763.2 ENSMUST00000064763.3 ENSMUST00000064763.4 ENSMUST00000064763.5 ENSMUST00000064763.6 Kiaa1281 NM_175751 Q56A10 Q6ZPU8 Q8BIG5 Q8BJ06 ZN608_MOUSE Znf608 uc008eyc.1 uc008eyc.2 uc008eyc.3 uc008eyc.4 Transcription factor, which represses ZNF609 transcription. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q56A10-1; Sequence=Displayed; Name=2; IsoId=Q56A10-2; Sequence=VSP_023667, VSP_023668; Name=3; IsoId=Q56A10-3; Sequence=VSP_023665, VSP_023666; Expressed at low levels in thymocytes. Sequence=BAC36234.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleic acid binding negative regulation of T cell differentiation in thymus metal ion binding uc008eyc.1 uc008eyc.2 uc008eyc.3 uc008eyc.4 
ENSMUST00000064771.12 Swt1 ENSMUST00000064771.12 SWT1 RNA endoribonuclease homolog (S. cerevisiae) (from RefSeq NM_025819.4) E9QP79 ENSMUST00000064771.1 ENSMUST00000064771.10 ENSMUST00000064771.11 ENSMUST00000064771.2 ENSMUST00000064771.3 ENSMUST00000064771.4 ENSMUST00000064771.5 ENSMUST00000064771.6 ENSMUST00000064771.7 ENSMUST00000064771.8 ENSMUST00000064771.9 NM_025819 Q6PAN2 Q7TMQ6 Q9DBQ9 SWT1_MOUSE uc007cyq.1 uc007cyq.2 uc007cyq.3 uc007cyq.4 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DBQ9-1; Sequence=Displayed; Name=2; IsoId=Q9DBQ9-2; Sequence=VSP_020736; Name=3; IsoId=Q9DBQ9-3; Sequence=VSP_020734, VSP_020735; Belongs to the SWT1 family. Sequence=AAH60204.1; Type=Frameshift; Evidence=; molecular_function nucleus uc007cyq.1 uc007cyq.2 uc007cyq.3 uc007cyq.4 
ENSMUST00000064780.4 Gabre ENSMUST00000064780.4 gamma-aminobutyric acid (GABA) A receptor, subunit epsilon (from RefSeq NM_017369.2) A2AMW3 A2AMW3_MOUSE ENSMUST00000064780.1 ENSMUST00000064780.2 ENSMUST00000064780.3 Gabre NM_017369 uc009tkm.1 uc009tkm.2 uc009tkm.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. Lacks conserved residue(s) required for the propagation of feature annotation. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity inhibitory extracellular ligand-gated ion channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction gamma-aminobutyric acid signaling pathway chemical synaptic transmission membrane integral component of membrane GABA-gated chloride ion channel activity dendrite membrane ion transmembrane transport regulation of membrane potential neuron projection synapse neurological system process synaptic transmission, GABAergic regulation of postsynaptic membrane potential postsynapse chloride transmembrane transport GABA-A receptor complex transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential benzodiazepine receptor activity uc009tkm.1 uc009tkm.2 uc009tkm.3 
ENSMUST00000064783.10 Mfap4 ENSMUST00000064783.10 microfibrillar-associated protein 4, transcript variant 2 (from RefSeq NM_029568.3) ENSMUST00000064783.1 ENSMUST00000064783.2 ENSMUST00000064783.3 ENSMUST00000064783.4 ENSMUST00000064783.5 ENSMUST00000064783.6 ENSMUST00000064783.7 ENSMUST00000064783.8 ENSMUST00000064783.9 MFAP4_MOUSE NM_029568 Q5NCN1 Q9D1H9 uc007jhm.1 uc007jhm.2 uc007jhm.3 Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance. Homodimer. Can also form higher oligomers. Interacts with FBN1, FBN2 and LOX. Interacts with COL1A1 in a Ca (2+)-dependent manner. Interacts with ELN in a Ca (2+)-dependent manner; this interaction promotes ELN self-assembly. Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D1H9-1; Sequence=Displayed; Name=2; IsoId=Q9D1H9-2; Sequence=VSP_013482; microfibril extracellular matrix structural constituent extracellular region extracellular space cell adhesion UV protection regulation of collagen metabolic process elastic fiber assembly cellular response to UV-B elastic fiber supramolecular fiber organization uc007jhm.1 uc007jhm.2 uc007jhm.3 
ENSMUST00000064786.12 Zfp672 ENSMUST00000064786.12 zinc finger protein 672, transcript variant 1 (from RefSeq NM_178761.5) ENSMUST00000064786.1 ENSMUST00000064786.10 ENSMUST00000064786.11 ENSMUST00000064786.2 ENSMUST00000064786.3 ENSMUST00000064786.4 ENSMUST00000064786.5 ENSMUST00000064786.6 ENSMUST00000064786.7 ENSMUST00000064786.8 ENSMUST00000064786.9 NM_178761 Q8BIR7 Q99LH4 ZN672_MOUSE Znf672 uc007jbc.1 uc007jbc.2 uc007jbc.3 uc007jbc.4 uc007jbc.5 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus nucleoplasm biological_process metal ion binding uc007jbc.1 uc007jbc.2 uc007jbc.3 uc007jbc.4 uc007jbc.5 
ENSMUST00000064794.14 Fgf7 ENSMUST00000064794.14 fibroblast growth factor 7 (from RefSeq NM_008008.4) ENSMUST00000064794.1 ENSMUST00000064794.10 ENSMUST00000064794.11 ENSMUST00000064794.12 ENSMUST00000064794.13 ENSMUST00000064794.2 ENSMUST00000064794.3 ENSMUST00000064794.4 ENSMUST00000064794.5 ENSMUST00000064794.6 ENSMUST00000064794.7 ENSMUST00000064794.8 ENSMUST00000064794.9 Fgf5b Fgf7 NM_008008 Q544I6 Q544I6_MOUSE uc012cdg.1 uc012cdg.2 Belongs to the heparin-binding growth factors family. fibroblast growth factor receptor binding extracellular region growth factor activity positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway mesenchymal cell proliferation positive regulation of keratinocyte proliferation actin cytoskeleton reorganization protein localization to cell surface chemoattractant activity positive regulation of epithelial cell proliferation positive regulation of peptidyl-tyrosine phosphorylation positive chemotaxis positive regulation of keratinocyte migration positive regulation of epithelial cell proliferation involved in lung morphogenesis secretion by lung epithelial cell involved in lung growth uc012cdg.1 uc012cdg.2 
ENSMUST00000064795.6 Egr1 ENSMUST00000064795.6 early growth response 1 (from RefSeq NM_007913.5) ENSMUST00000064795.1 ENSMUST00000064795.2 ENSMUST00000064795.3 ENSMUST00000064795.4 ENSMUST00000064795.5 Egr1 NM_007913 Q544D6 Q544D6_MOUSE uc008elt.1 uc008elt.2 uc008elt.3 Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Cytoplasm Nucleus Belongs to the EGR C2H2-type zinc-finger protein family. transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytoplasm transcription from RNA polymerase II promoter zinc ion binding double-stranded methylated DNA binding positive regulation of gene expression regulation of protein sumoylation histone acetyltransferase binding sequence-specific DNA binding hemi-methylated DNA-binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding interleukin-1-mediated signaling pathway cellular response to interleukin-8 positive regulation of neuron death positive regulation of tau-protein kinase activity promoter-specific chromatin binding uc008elt.1 uc008elt.2 uc008elt.3 
ENSMUST00000064797.12 Itsn1 ENSMUST00000064797.12 Cytoplasm (from UniProt E9Q0N0) BC172688 E9Q0N0 E9Q0N0_MOUSE ENSMUST00000064797.1 ENSMUST00000064797.10 ENSMUST00000064797.11 ENSMUST00000064797.2 ENSMUST00000064797.3 ENSMUST00000064797.4 ENSMUST00000064797.5 ENSMUST00000064797.6 ENSMUST00000064797.7 ENSMUST00000064797.8 ENSMUST00000064797.9 Itsn1 uc289gcr.1 uc289gcr.2 Cytoplasm guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity calcium ion binding regulation of Rho protein signal transduction intracellular signal transduction uc289gcr.1 uc289gcr.2 
ENSMUST00000064798.16 Ndufv3 ENSMUST00000064798.16 NADH:ubiquinone oxidoreductase core subunit V3, transcript variant 2 (from RefSeq NM_001083891.1) ENSMUST00000064798.1 ENSMUST00000064798.10 ENSMUST00000064798.11 ENSMUST00000064798.12 ENSMUST00000064798.13 ENSMUST00000064798.14 ENSMUST00000064798.15 ENSMUST00000064798.2 ENSMUST00000064798.3 ENSMUST00000064798.4 ENSMUST00000064798.5 ENSMUST00000064798.6 ENSMUST00000064798.7 ENSMUST00000064798.8 ENSMUST00000064798.9 NDUV3_MOUSE NM_001083891 Q8BK30 uc008bvf.1 uc008bvf.2 uc008bvf.3 uc008bvf.4 uc008bvf.5 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I. Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the complex I NDUFV3 subunit family. nucleoplasm mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I membrane mitochondrial ATP synthesis coupled electron transport oxidation-reduction process respiratory chain uc008bvf.1 uc008bvf.2 uc008bvf.3 uc008bvf.4 uc008bvf.5 
ENSMUST00000064809.9 Gm9889 ENSMUST00000064809.9 predicted gene 9889 (from RefSeq NR_189022.1) ENSMUST00000064809.1 ENSMUST00000064809.2 ENSMUST00000064809.3 ENSMUST00000064809.4 ENSMUST00000064809.5 ENSMUST00000064809.6 ENSMUST00000064809.7 ENSMUST00000064809.8 NR_189022 uc290ixu.1 uc290ixu.2 uc290ixu.3 uc290ixu.4 uc290ixu.1 uc290ixu.2 uc290ixu.3 uc290ixu.4 
ENSMUST00000064848.7 Nup107 ENSMUST00000064848.7 nucleoporin 107, transcript variant 1 (from RefSeq NM_134010.3) ENSMUST00000064848.1 ENSMUST00000064848.2 ENSMUST00000064848.3 ENSMUST00000064848.4 ENSMUST00000064848.5 ENSMUST00000064848.6 NM_134010 NU107_MOUSE Q8BH74 Q99KH5 uc007hdo.1 uc007hdo.2 uc007hdo.3 Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis. Part of the nuclear pore complex (NPC) (By similarity). Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96; this complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus (By similarity). Does not interact with TPR (By similarity). Interacts with ZNF106 (PubMed:28072389). Nucleus membrane Nucleus, nuclear pore complex Chromosome, centromere, kinetochore Note=Located on both the cytoplasmic and nuclear sides of the NPC core structure. During mitosis, localizes to the kinetochores. Dissociates from the dissasembled NPC structure late during prophase of mitosis. Belongs to the nucleoporin Nup84/Nup107 family. chromosome, centromeric region kinetochore condensed chromosome kinetochore posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery nucleus nuclear pore chromosome mRNA export from nucleus protein import into nucleus female gonad development protein transport membrane structural constituent of nuclear pore nuclear pore outer ring nuclear membrane nuclear periphery mRNA transport nuclear pore complex assembly nephron development uc007hdo.1 uc007hdo.2 uc007hdo.3 
ENSMUST00000064853.13 1700030K09Rik ENSMUST00000064853.13 RIKEN cDNA 1700030K09 gene (from RefSeq NM_028170.2) CS044_MOUSE ENSMUST00000064853.1 ENSMUST00000064853.10 ENSMUST00000064853.11 ENSMUST00000064853.12 ENSMUST00000064853.2 ENSMUST00000064853.3 ENSMUST00000064853.4 ENSMUST00000064853.5 ENSMUST00000064853.6 ENSMUST00000064853.7 ENSMUST00000064853.8 ENSMUST00000064853.9 NM_028170 Q3UZJ9 Q922C1 uc009mfy.1 uc009mfy.2 uc009mfy.3 uc009mfy.4 molecular_function cellular_component biological_process uc009mfy.1 uc009mfy.2 uc009mfy.3 uc009mfy.4 
ENSMUST00000064856.9 Cpn2 ENSMUST00000064856.9 carboxypeptidase N, polypeptide 2 (from RefSeq NM_027904.3) B2RR89 CPN2_MOUSE ENSMUST00000064856.1 ENSMUST00000064856.2 ENSMUST00000064856.3 ENSMUST00000064856.4 ENSMUST00000064856.5 ENSMUST00000064856.6 ENSMUST00000064856.7 ENSMUST00000064856.8 NM_027904 Q8R113 Q9DBB9 uc007ywm.1 uc007ywm.2 uc007ywm.3 uc007ywm.4 The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit (By similarity). Tetramer of two catalytic chains and two glycosylated inactive chains. Secreted Sequence=AAH25836.1; Type=Erroneous initiation; Evidence=; Sequence=BAB23775.1; Type=Erroneous initiation; Evidence=; molecular_function extracellular region extracellular space biological_process extracellular matrix uc007ywm.1 uc007ywm.2 uc007ywm.3 uc007ywm.4 
ENSMUST00000064873.9 C8a ENSMUST00000064873.9 complement component 8, alpha polypeptide, transcript variant 1 (from RefSeq NM_146148.3) CO8A_MOUSE ENSMUST00000064873.1 ENSMUST00000064873.2 ENSMUST00000064873.3 ENSMUST00000064873.4 ENSMUST00000064873.5 ENSMUST00000064873.6 ENSMUST00000064873.7 ENSMUST00000064873.8 NM_146148 Q8CHJ9 Q8CHK1 Q8K182 uc008tya.1 uc008tya.2 uc008tya.3 uc008tya.4 uc008tya.5 This gene encodes the alpha subunit of complement component C8 that participates in the assembly of the complement membrane attack complex. The encoded preproprotein undergoes proteolytic processing to generate the alpha subunit, which associates with the beta and gamma subunits to form a trimeric complement component, C8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. This gene is located adjacent to the gene encoding the beta subunit. [provided by RefSeq, Oct 2015]. Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b sequentially binds C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity). Secreted Cell membrane ; Multi-pass membrane protein Note=Secreted as soluble protein. Inserts into the cell membrane of target cells (By similarity). Belongs to the complement C6/C7/C8/C9 family. complement binding immune system process extracellular region membrane attack complex extracellular space plasma membrane immune response complement activation complement activation, alternative pathway complement activation, classical pathway membrane integral component of membrane cytolysis macromolecular complex binding innate immune response uc008tya.1 uc008tya.2 uc008tya.3 uc008tya.4 uc008tya.5 
ENSMUST00000064883.14 Plekha2 ENSMUST00000064883.14 pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2, transcript variant 7 (from RefSeq NM_001427351.1) ENSMUST00000064883.1 ENSMUST00000064883.10 ENSMUST00000064883.11 ENSMUST00000064883.12 ENSMUST00000064883.13 ENSMUST00000064883.2 ENSMUST00000064883.3 ENSMUST00000064883.4 ENSMUST00000064883.5 ENSMUST00000064883.6 ENSMUST00000064883.7 ENSMUST00000064883.8 ENSMUST00000064883.9 NM_001427351 PKHA2_MOUSE Q8BY29 Q9ERS5 Tapp2 uc009lfr.1 uc009lfr.2 uc009lfr.3 uc009lfr.4 uc009lfr.5 Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. Binds MPDZ and PTPN13. Q9ERS5; O75970: MPDZ; Xeno; NbExp=5; IntAct=EBI-8079166, EBI-821405; Cytoplasm Cell membrane ; Peripheral membrane protein Nucleus Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. positive regulation of cell-matrix adhesion fibronectin binding protein binding nucleus cytoplasm plasma membrane lipid binding membrane PDZ domain binding macromolecular complex laminin binding phosphatidylinositol-3,4-bisphosphate binding uc009lfr.1 uc009lfr.2 uc009lfr.3 uc009lfr.4 uc009lfr.5 
ENSMUST00000064900.16 Pias3 ENSMUST00000064900.16 protein inhibitor of activated STAT 3, transcript variant 3 (from RefSeq NM_001165949.1) ENSMUST00000064900.1 ENSMUST00000064900.10 ENSMUST00000064900.11 ENSMUST00000064900.12 ENSMUST00000064900.13 ENSMUST00000064900.14 ENSMUST00000064900.15 ENSMUST00000064900.2 ENSMUST00000064900.3 ENSMUST00000064900.4 ENSMUST00000064900.5 ENSMUST00000064900.6 ENSMUST00000064900.7 ENSMUST00000064900.8 ENSMUST00000064900.9 NM_001165949 O54714 PIAS3_MOUSE Q80WF8 Q8R598 uc008qnv.1 uc008qnv.2 uc008qnv.3 uc008qnv.4 Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Repressor of STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Repressor of MITF transcriptional activity. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1 (By similarity). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity). Protein modification; protein sumoylation. Monomer. Interacts with PLAG1 and ZFHX3. Interacts with STAT5A; the interaction occurs on stimulation by PRL (By similarity). Binds SUMO1 and UBE2I. Interacts with AR, BCL11A, HMGA2, IRF1 and NCOA2. Interacts with MITF; the interaction inhibits the transcriptional activity of MITF. Interacts with STAT3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. Interacts with GFI1; the interaction relieves the inhibitory effect of PIAS3 on STAT3-mediated transcriptional activity. Interacts with MTA1. Interacts with CCAR2 (via N-terminus) (By similarity). Interacts with TRIM8 (By similarity). Interacts with PRDM1 (By similarity). O54714; P70338: Gfi1; NbExp=6; IntAct=EBI-927969, EBI-3954754; Cytoplasm cleus cleus speckle Note=Colocalizes with MITF in the nucleus (PubMed:11709556). Colocalizes with GFI1 in nuclear dots (PubMed:11060035). Colocalizes with SUMO1 in nuclear granules (PubMed:12077349). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O54714-1; Sequence=Displayed; Name=2; IsoId=O54714-2; Sequence=VSP_012203; Name=3; IsoId=O54714-3; Sequence=VSP_012204; Expressed in kidney, heart, spleen, brain and cerebellum; weak expression, if any, in liver and lung. Expressed as early as 7.6 dpc. Expression remains high through 15.5 dpc. The LXXLL motif is a transcriptional coregulator signature. Sumoylated. Belongs to the PIAS family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding transcription cofactor activity protein binding nucleus cytoplasm regulation of transcription from RNA polymerase II promoter protein C-terminus binding zinc ion binding response to hormone positive regulation of gene expression negative regulation of gene expression potassium channel regulator activity nuclear speck transferase activity protein sumoylation SUMO transferase activity enzyme binding dendrite negative regulation of protein sumoylation positive regulation of protein sumoylation synapse negative regulation of osteoclast differentiation positive regulation of membrane potential negative regulation of transcription, DNA-templated metal ion binding protein N-terminus binding SUMO ligase activity TNFSF11-mediated signaling pathway uc008qnv.1 uc008qnv.2 uc008qnv.3 uc008qnv.4 
ENSMUST00000064910.7 Strap ENSMUST00000064910.7 serine/threonine kinase receptor associated protein (from RefSeq NM_011499.3) ENSMUST00000064910.1 ENSMUST00000064910.2 ENSMUST00000064910.3 ENSMUST00000064910.4 ENSMUST00000064910.5 ENSMUST00000064910.6 NM_011499 Q8BP89 Q8C6F6 Q9Z1Z2 STRAP_MOUSE Unrip uc012euz.1 uc012euz.2 uc012euz.3 The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre- mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity). Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with GEMIN6 and GEMIN7. Associates with the SMN complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Interacts with TRIM48. Cytoplasm Nucleus Note=Localized predominantly in the cytoplasm but also found in the nucleus. Belongs to the WD repeat STRAP family. negative regulation of transcription from RNA polymerase II promoter spliceosomal snRNP assembly receptor binding protein binding nucleus nucleoplasm cytoplasm cytosol mRNA processing RNA splicing negative regulation of epithelial cell migration negative regulation of epithelial to mesenchymal transition maintenance of gastrointestinal epithelium negative regulation of transforming growth factor beta receptor signaling pathway SMN complex SMN-Sm protein complex negative regulation of epithelial cell proliferation negative regulation of pathway-restricted SMAD protein phosphorylation uc012euz.1 uc012euz.2 uc012euz.3 
ENSMUST00000064922.7 Junb ENSMUST00000064922.7 jun B proto-oncogene (from RefSeq NM_008416.3) ENSMUST00000064922.1 ENSMUST00000064922.2 ENSMUST00000064922.3 ENSMUST00000064922.4 ENSMUST00000064922.5 ENSMUST00000064922.6 Junb NM_008416 Q569U6 Q569U6_MOUSE uc012ghn.1 uc012ghn.2 uc012ghn.3 uc012ghn.4 Nucleus Belongs to the bZIP family. Jun subfamily. DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription factor AP-1 complex positive regulation of transcription from RNA polymerase II promoter regulation of cell cycle uc012ghn.1 uc012ghn.2 uc012ghn.3 uc012ghn.4 
ENSMUST00000064924.6 Espl1 ENSMUST00000064924.6 extra spindle pole bodies 1, separase, transcript variant 1 (from RefSeq NM_001014976.2) A6H6E3 ENSMUST00000064924.1 ENSMUST00000064924.2 ENSMUST00000064924.3 ENSMUST00000064924.4 ENSMUST00000064924.5 ESPL1_MOUSE Esp1 Kiaa0165 NM_001014976 P60330 uc007xvf.1 uc007xvf.2 uc007xvf.3 uc007xvf.4 Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms (By similarity). Reaction=All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.; EC=3.4.22.49; Regulated by at least two independent mechanisms. First, it is inactivated via its interaction with securin/PTTG1, which probably covers its active site. The association with PTTG1 is not only inhibitory, since PTTG1 is also required for activating it, the enzyme being inactive in cells in which PTTG1 is absent. PTTG1 degradation at anaphase, liberates it and triggers RAD21 cleavage. Second, phosphorylation at Ser-1121 inactivates it. The complete phosphorylation during mitosis, is removed when cells undergo anaphase. Activation of the enzyme at the metaphase-anaphase transition probably requires the removal of both securin and inhibitory phosphate (By similarity). Interacts with PTTG1. Interacts with RAD21 (By similarity). Cytoplasm Nucleus Autocleaves. This function, which is not essential for its protease activity, is unknown (By similarity). Phosphorylated by CDK1. There is 8 Ser/Thr phosphorylation sites. Among them, only Ser-1121 phosphorylation is the major site, which conducts to the enzyme inactivation (By similarity). Sequence=BAC97882.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; mitotic sister chromatid segregation meiotic spindle organization mitotic cell cycle cysteine-type endopeptidase activity nucleus cytoplasm centrosome proteolysis chromosome segregation meiosis I peptidase activity cysteine-type peptidase activity hydrolase activity homologous chromosome segregation meiotic chromosome separation mitotic spindle uc007xvf.1 uc007xvf.2 uc007xvf.3 uc007xvf.4 
ENSMUST00000064932.6 Tas2r137 ENSMUST00000064932.6 taste receptor, type 2, member 137 (from RefSeq NM_001025385.1) A0A0R4J0T3 A0A0R4J0T3_MOUSE ENSMUST00000064932.1 ENSMUST00000064932.2 ENSMUST00000064932.3 ENSMUST00000064932.4 ENSMUST00000064932.5 NM_001025385 Tas2r137 uc009bmv.1 uc009bmv.2 uc009bmv.3 Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Membrane ulti-pass membrane protein Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009bmv.1 uc009bmv.2 uc009bmv.3 
ENSMUST00000064937.14 Nrk ENSMUST00000064937.14 Nik related kinase (from RefSeq NM_013724.2) B2RSW5 ENSMUST00000064937.1 ENSMUST00000064937.10 ENSMUST00000064937.11 ENSMUST00000064937.12 ENSMUST00000064937.13 ENSMUST00000064937.2 ENSMUST00000064937.3 ENSMUST00000064937.4 ENSMUST00000064937.5 ENSMUST00000064937.6 ENSMUST00000064937.7 ENSMUST00000064937.8 ENSMUST00000064937.9 NM_013724 NRK_MOUSE Nesk Q6NV55 Q8C9S9 Q9R0G8 Q9R0S4 uc009ujx.1 uc009ujx.2 uc009ujx.3 uc009ujx.4 May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Predominantly expressed in skeletal muscle during embryogenesis. Expression was detected in the myotome at 10.5 dpc and, thereafter, was observed in developing skeletal musculature from 11.5 to 13.5 dpc and increased from 15 to 17 dpc. However, expression in skeletal muscle was not observed in adults. Its expression may be down- regulated as development proceeds. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Sequence=AAH68311.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm protein phosphorylation activation of JNKK activity parturition negative regulation of cell proliferation kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation actin cytoskeleton reorganization activation of protein kinase activity neuron projection morphogenesis regulation of spongiotrophoblast cell proliferation uc009ujx.1 uc009ujx.2 uc009ujx.3 uc009ujx.4 
ENSMUST00000064941.7 Nr1d1 ENSMUST00000064941.7 nuclear receptor subfamily 1, group D, member 1 (from RefSeq NM_145434.4) ENSMUST00000064941.1 ENSMUST00000064941.2 ENSMUST00000064941.3 ENSMUST00000064941.4 ENSMUST00000064941.5 ENSMUST00000064941.6 Ear1 NM_145434 NR1D1_MOUSE Q3UJJ1 Q3UV55 Q62171 Q6EEZ6 Q922A5 Q9ESY4 uc007lhh.1 uc007lhh.2 uc007lhh.3 uc007lhh.4 This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Feb 2014]. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008989.1, AK146430.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha- cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose- induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (PubMed:30555544). Represses the transcription of CES2 (PubMed:29653076). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (PubMed:24794873). Negatively regulates the protein stability of NR3C1 and influences the time- dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (PubMed:27686098). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (PubMed:29533925). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF- kappaB pathway in the central nervous system (PubMed:30792350). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (PubMed:30096135). Binds DNA as a monomer or a homodimer (By similarity). Interacts with NR2E3 and ZNHIT1 (By similarity). Interacts with C1D (PubMed:9405624). Interacts with SP1 (PubMed:22549838). Interacts with OPHN1 (via C-terminus) (PubMed:21874017). Interacts with PER2; the interaction associates PER2 to BMAL1 promoter region (PubMed:20159955, PubMed:22170608). Interacts with CRY1 (By similarity). Interacts with CCAR2 (PubMed:23398316). Interacts with SIAH2 (By similarity). Interacts with FBXW7 and CDK1 (PubMed:27238018). Interacts with HUWE1 (By similarity). Interacts with NR0B2 (PubMed:25212631, PubMed:30555544). Interacts with NFIL3 (PubMed:29653076). Interacts (via domain NR LBD) with HSP90AA1 and HSP90AB1 (PubMed:27686098). Nucleus toplasm ll projection, dendrite Cell projection, dendritic spine Note=Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1 (PubMed:21874017). Localizes predominantly to the nucleus at ZT8 whereas it is cytoplasmic at ZT20 (PubMed:27686098). Phosphorylation by CSNK1E enhances its cytoplasmic localization (PubMed:29508494). Expressed during adipocyte differentiation (at protein level). Expressed in skeletal muscle, bladder, lumbar spinal cord, pancreatic islets and hypothalamus. Expressed in developing and adult retina. In the adult retina, predominantly expressed in the outer nuclear layer, where rod and cone cells reside, and also localized to the ganglion cell layer. Expressed in a circadian manner in the liver (PubMed:27686098). Expressed in a circadian manner in the lung with a peak between ZT8 and ZT12 (PubMed:29533925). During development at embryonic day 18.5 dpc, expressed in the outer neuroblastic layer of the retina where developing postmitotic photoreceptors and retinal progenitors reside (at protein level). Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues. In bladder smooth muscle cells, pancreas and lumbar spinal cord, exhibits night/day variations with a peak time at circadian time (CT) 4-12 and a trough at CT16-24. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Ubiquitinated, leading to its proteasomal degradation (PubMed:20534529). Ubiquitinated by the SCF(FBXW7) complex when phosphorylated by CDK1 leading to its proteasomal degradation (PubMed:27238018). Ubiquitinated by SIAH2; leading to its proteasomal degradation (By similarity). Rapidly ubiquitinated in response to inflammatory triggers and sumoylation is a prerequisite to its ubiquitination (PubMed:29533925). Sumoylated by UBE2I, desumoylated by SENP1, and sumoylation is a prerequisite to its ubiquitination. Phosphorylated by CSNK1E; phosphorylation enhances its cytoplasmic localization. Undergoes lysosome-mediated degradation in a time-dependent manner in the liver. Mice display increased cold tolerance, higher oxygen consumption rates, enhanced brown adipose tissue metabolic capacity, maintenance of higher body temperature throughout the light phase and increased glucose uptake only during the day. They also show retinal abnormalities such as pan-retinal spotting and decreased response to light and decreased bile acid accumulation. Double knockout for NR1D1 and PER2 show a significantly shorter period length compared with wild type or single knockouts for both genes. 50% of double knockouts animals show a stable circadian throughout at least 5 weeks in constant darkness. The other 50% of animals lose their circadian rhythmicity when held in constant darkness for an average of 21 days. Animals have blunted steady-state levels of glycogen in the liver in spite of normal patterns of food consumption. Mice show exaggerated pulmonary inflammatory responses (PubMed:29533925). Mice display enhanced spontaneous hippocampal microglial and astrocyte activation, increased microglial NF-kappaB signaling and exacerbated LPS-induced neuroinflammation in the hippocampus (PubMed:30792350). Conditional knockout of both NR1D1 and NR1D2 in bronchiolar epithelial cells abolished diurnal rhythmicity of PER2 in the bronchioles and increased inflammatory responses and chemokine activation (PubMed:29533925). Belongs to the nuclear hormone receptor family. NR1 subfamily. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription corepressor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity protein binding nucleus nucleoplasm cytoplasm glycogen biosynthetic process regulation of transcription, DNA-templated multicellular organism development circadian rhythm transcription factor binding zinc ion binding hormone-mediated signaling pathway proteasomal protein catabolic process negative regulation of receptor biosynthetic process nuclear body regulation of lipid metabolic process heme binding cell differentiation ligand-dependent nuclear receptor transcription coactivator activity dendrite protein destabilization circadian regulation of gene expression response to lipid negative regulation of toll-like receptor 4 signaling pathway regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter signaling receptor activity cholesterol homeostasis regulation of circadian sleep/wake cycle regulation of circadian rhythm positive regulation of circadian rhythm cell projection neuronal cell body negative regulation of I-kappaB kinase/NF-kappaB signaling dendritic spine steroid hormone mediated signaling pathway sequence-specific DNA binding transcription regulatory region DNA binding response to leptin regulation of fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding rhythmic process negative regulation of inflammatory response circadian temperature homeostasis regulation of insulin secretion involved in cellular response to glucose stimulus regulation of type B pancreatic cell proliferation positive regulation of bile acid biosynthetic process E-box binding cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor RNA polymerase II transcription factor complex negative regulation of microglial cell activation sequence-specific double-stranded DNA binding regulation of hepatic stellate cell activation uc007lhh.1 uc007lhh.2 uc007lhh.3 uc007lhh.4 
ENSMUST00000064948.13 Dnah6 ENSMUST00000064948.13 dynein, axonemal, heavy chain 6 (from RefSeq NM_001164669.1) Dnah6 Dnahc6 E9Q0B6 E9Q0B6_MOUSE ENSMUST00000064948.1 ENSMUST00000064948.10 ENSMUST00000064948.11 ENSMUST00000064948.12 ENSMUST00000064948.2 ENSMUST00000064948.3 ENSMUST00000064948.4 ENSMUST00000064948.5 ENSMUST00000064948.6 ENSMUST00000064948.7 ENSMUST00000064948.8 ENSMUST00000064948.9 NM_001164669 uc009cjk.1 uc009cjk.2 uc009cjk.3 uc009cjk.4 Belongs to the dynein heavy chain family. cilium movement microtubule motor activity ATP binding microtubule-based movement ATP-dependent microtubule motor activity, minus-end-directed dynein complex inner dynein arm dynein intermediate chain binding dynein light intermediate chain binding uc009cjk.1 uc009cjk.2 uc009cjk.3 uc009cjk.4 
ENSMUST00000064989.12 Prkcb ENSMUST00000064989.12 protein kinase C, beta, transcript variant 1 (from RefSeq NM_008855.2) A0JNZ5 ENSMUST00000064989.1 ENSMUST00000064989.10 ENSMUST00000064989.11 ENSMUST00000064989.2 ENSMUST00000064989.3 ENSMUST00000064989.4 ENSMUST00000064989.5 ENSMUST00000064989.6 ENSMUST00000064989.7 ENSMUST00000064989.8 ENSMUST00000064989.9 F2Z441 KPCB_MOUSE NM_008855 P04410 P04411 P68404 Pkcb Prkcb1 uc009jou.1 uc009jou.2 uc009jou.3 uc009jou.4 Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin- stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain. ; Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-500 (activation loop of the kinase domain), Thr-642 (turn motif) and Ser- 661 (hydrophobic region), need to be phosphorylated for its full activation. Specifically inhibited by enzastaurin (LY317615) (By similarity). Interacts with PDK1. Interacts in vitro with PRKCBP1. Interacts with PHLPP1 and PHLPP2; both proteins mediate its dephosphorylation. Interacts with KDM1A/LSD1, PKN1 and ANDR (By similarity). P68404; Q13873: BMPR2; Xeno; NbExp=4; IntAct=EBI-397048, EBI-527196; P68404; P56537: EIF6; Xeno; NbExp=2; IntAct=EBI-397048, EBI-372243; P68404-2; P48736: PIK3CG; Xeno; NbExp=2; IntAct=EBI-16063464, EBI-1030384; Cytoplasm Nucleus Membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=Beta-I; IsoId=P68404-1; Sequence=Displayed; Name=Beta-II; IsoId=P68404-2; Sequence=VSP_041812; Phosphorylation on Thr-500 within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr- 642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Autophosphorylation on other sites i.e. in the N-terminal and hinge regions have no effect on enzyme activity (By similarity). Phosphorylation at Tyr-662 by SYK induces binding with GRB2 and contributes to the activation of MAPK/ERK signaling cascade. Mice develop an immunodeficiency characterized by impaired humoral immune responses and reduced cellular responses of B- cells similar to X-linked immunodeficiency (Xid). Mice are unable to activate NF-kappa-B and promote cell survival in B-cells upon BCR signaling, or even in mast cells. B-cells fail to recruit the I-kappa-B kinase (IKK) complex into lipid rafts, activate IKK, degrade I-kappa-B or up-regulate NF-kappa-B-dependent survival signals. Moreover, mutant animals are hyperphagic and exhibit higher food intake and reduced feed efficiency versus wild type. Mice are considerably leaner and display markedly decreased size of white fat depots. Triglyceride content in the liver and skeletal muscle is also significantly low. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. nucleotide binding response to hypoxia adaptive immune response immune system process chromatin binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein kinase C binding calcium channel regulator activity protein binding ATP binding nucleus nucleoplasm cytoplasm centrosome cytosol plasma membrane chromatin organization regulation of transcription from RNA polymerase II promoter protein phosphorylation calcium ion transport cellular calcium ion homeostasis apoptotic process zinc ion binding regulation of glucose transport negative regulation of glucose transport regulation of dopamine secretion membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation ligand-dependent nuclear receptor transcription coactivator activity positive regulation of vascular endothelial growth factor receptor signaling pathway brush border membrane histone kinase activity (H3-T6 specific) histone H3-T6 phosphorylation intracellular signal transduction regulation of growth B cell activation histone binding response to drug positive regulation of I-kappaB kinase/NF-kappaB signaling calyx of Held positive regulation of angiogenesis negative regulation of insulin receptor signaling pathway metal ion binding androgen receptor binding B cell receptor signaling pathway positive regulation of B cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity cellular response to carbohydrate stimulus presynaptic cytosol positive regulation of nucleic acid-templated transcription regulation of synaptic vesicle exocytosis uc009jou.1 uc009jou.2 uc009jou.3 uc009jou.4 
ENSMUST00000064993.8 Ghrl ENSMUST00000064993.8 ghrelin, transcript variant 1 (from RefSeq NM_021488.5) ENSMUST00000064993.1 ENSMUST00000064993.2 ENSMUST00000064993.3 ENSMUST00000064993.4 ENSMUST00000064993.5 ENSMUST00000064993.6 ENSMUST00000064993.7 GHRL_MOUSE Mtlrp NM_021488 Q9EQX0 Q9WUZ1 uc009dhl.1 uc009dhl.2 uc009dhl.3 uc009dhl.4 This gene encodes a preproprotein that undergoes proteolytic processing to yield two bioactive peptides, ghrelin and obestatin. The hormone ghrelin plays a role in enhancing appetite and has numerous other biological functions that include stimulating the secretion of growth hormone (somatotropin) from the anterior pituitary gland. Obestatin is thought to be a hormone that functions in decreasing appetite. Mice lacking the encoded protein develop normally and exhibit no gross anatomical abnormalities. This gene encodes distinct isoforms, some or all of which may undergo similar proteolytic processing. [provided by RefSeq, Jul 2016]. [Ghrelin]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. [Obestatin]: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). Secreted Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Ghrelin; IsoId=Q9EQX0-1; Sequence=Displayed; Name=2; Synonyms=des-Gln14-ghrelin; IsoId=Q9EQX0-2; Sequence=VSP_003246; Mainly expressed in the gastrointestinal tract with higher levels in the stomach, medium levels in the duodenum, jejunum, ileum and colon. Low expression in the testis and brain. Not detected in the salivary gland, pancreas, liver and lung. Levels of n-octanoylated and n-decanoylated ghrelin drop by one third and 3-fold, respectively, between postnatal weeks 3 and 4 due to change of diet during weaning. O-octanoylated by GOAT/MBOAT4 (PubMed:18443287). O-octanoylation or O-decanoylation is essential for ghrelin activity (By similarity). The O-decanoylated form ghrelin-C10 differs in the length of the carbon backbone of the carboxylic acid bound to Ser-26 (PubMed:15746259). Amidation of Leu-98 is essential for obestatin activity. [Ghrelin]: Mass=3314; Method=MALDI; Note=Ghrelin, O- octanoylated form.; Evidence=; Belongs to the motilin family. Name=Protein Spotlight; Note=Gut feelings - Issue 66 of January 2006; URL="https://web.expasy.org/spotlight/back_issues/066"; activation of MAPK activity G-protein coupled receptor binding gastric acid secretion negative regulation of endothelial cell proliferation hormone activity extracellular region extracellular space cytoplasm G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration actin polymerization or depolymerization adult feeding behavior visual learning response to hormone dendrite development growth hormone-releasing hormone activity protein tyrosine kinase activator activity axon response to nutrient levels ghrelin receptor binding positive regulation of insulin secretion regulation of response to food positive regulation of response to food positive regulation of appetite negative regulation of interleukin-1 beta production gastric emptying positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of growth rate negative regulation of locomotion regulation of cell proliferation negative regulation of circadian sleep/wake cycle, REM sleep negative regulation of tumor necrosis factor biosynthetic process negative regulation of apoptotic process response to estrogen negative regulation of interleukin-6 biosynthetic process positive regulation of growth positive regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of insulin secretion decidualization negative regulation of inflammatory response positive regulation of corticotropin secretion positive regulation of cortisol secretion response to electrical stimulus positive regulation of synapse assembly regulation of transmission of nerve impulse excitatory postsynaptic potential positive regulation of growth hormone secretion positive regulation of protein tyrosine kinase activity postsynapse glutamatergic synapse positive regulation of bone development positive regulation of sprouting angiogenesis positive regulation of eating behavior positive regulation of adipose tissue development positive regulation of gastro-intestinal system smooth muscle contraction positive regulation of gastric mucosal blood circulation positive regulation of small intestine smooth muscle contraction negative regulation of tumor necrosis factor secretion regulation of gastric motility positive regulation of vascular endothelial cell proliferation positive regulation of feeding behavior uc009dhl.1 uc009dhl.2 uc009dhl.3 uc009dhl.4 
ENSMUST00000065005.5 Atg4d ENSMUST00000065005.5 autophagy related 4D, cysteine peptidase (from RefSeq NM_153583.10) ATG4D_MOUSE Apg4d Atg4d Autl4 ENSMUST00000065005.1 ENSMUST00000065005.2 ENSMUST00000065005.3 ENSMUST00000065005.4 NM_153583 Q8BGV9 Q8C4N9 Q8K0Q2 uc009okt.1 uc009okt.2 uc009okt.3 uc009okt.4 [Cysteine protease ATG4D]: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:33795848). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (By similarity). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:33795848). Catalyzes delipidation of PE- conjugated forms of ATG8 proteins during macroautophagy (PubMed:33795848). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (By similarity). ATG4D plays a role in the autophagy-mediated neuronal homeostasis in the central nervous system (PubMed:33795848). Compared to other members of the family (ATG4A, ATG4B or ATG4C), constitutes the major protein for the delipidation activity, while it promotes weak proteolytic activation of ATG8 proteins (PubMed:33795848). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (By similarity). [Cysteine protease ATG4D, mitochondrial]: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability. Reaction=[protein]-C-terminal L-amino acid-glycyl- phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid- glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:67548, Rhea:RHEA-COMP:17323, Rhea:RHEA-COMP:17324, ChEBI:CHEBI:15377, ChEBI:CHEBI:64612, ChEBI:CHEBI:172940, ChEBI:CHEBI:172941; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67549; Evidence=; Reaction=[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn- glycero-3-phospho-L-serine; Xref=Rhea:RHEA:67576, Rhea:RHEA- COMP:17324, Rhea:RHEA-COMP:17326, ChEBI:CHEBI:15377, ChEBI:CHEBI:57262, ChEBI:CHEBI:172940, ChEBI:CHEBI:172942; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67577; Evidence=; Inhibited by N-ethylmaleimide. [Cysteine protease ATG4D]: Cytoplasm [Cysteine protease ATG4D, mitochondrial]: Cytoplasm Mitochondrion matrix Note=Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death. The cryptic mitochondrial transit peptide is revealed after cleavage by caspase upon oxidative stress and cell death. It acts then as a functional transit peptide, and allows the import of the cleaved protein into the mitochondria. Cleaved by CASP3 during apoptosis which leads to increased activity. The cleavage by CASP3 reveals a cryptic mitochondrial targeting sequence immediately downstream of their canonical caspase cleavage sites which leads to mitochondrial import of the protein. Mice develop normally and are born at the expected Mendelian ration (PubMed:33795848). Cells display accumulation of lipidated forms of ATG8 family proteins, affecting autophagosome number and size without significantly altering autophagic flux (PubMed:33795848). Mice show cerebellar neurodegeneration and impaired motor coordination, whose severity increases with age (PubMed:33795848). Belongs to the peptidase C54 family. cytoplasm mitochondrion mitochondrial matrix proteolysis autophagy apoptotic process peptidase activity cysteine-type peptidase activity protein transport hydrolase activity uc009okt.1 uc009okt.2 uc009okt.3 uc009okt.4 
ENSMUST00000065014.10 Lamb2 ENSMUST00000065014.10 laminin, beta 2, transcript variant 1 (from RefSeq NM_008483.4) ENSMUST00000065014.1 ENSMUST00000065014.2 ENSMUST00000065014.3 ENSMUST00000065014.4 ENSMUST00000065014.5 ENSMUST00000065014.6 ENSMUST00000065014.7 ENSMUST00000065014.8 ENSMUST00000065014.9 LAMB2_MOUSE Lams NM_008483 Q61292 Q62182 Q8R0Y0 uc009rpr.1 uc009rpr.2 uc009rpr.3 uc009rpr.4 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin-3 (S-laminin) regulates the formation of motor nerve terminals. Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-7 (laminin-321 or KS-laminin), laminin-9 (laminin-421), laminin-11 (laminin-521), laminin-14 (laminin-423) and laminin-15 (laminin-523). Secreted, extracellular space, extracellular matrix, basement membrane. Neuromuscular synapse and kidney glomerulus. The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. Domains VI and IV are globular. cell morphogenesis involved in differentiation integrin binding extracellular matrix structural constituent extracellular region basement membrane laminin-3 complex extracellular space cell adhesion axon guidance neuromuscular junction development visual perception animal organ morphogenesis tissue development astrocyte development Schwann cell development cell migration neuron projection development neuromuscular junction substrate adhesion-dependent cell spreading synaptic cleft laminin complex synapse axon extension involved in regeneration synapse organization retina development in camera-type eye basement membrane assembly metanephric glomerular visceral epithelial cell development metanephric glomerular basement membrane development uc009rpr.1 uc009rpr.2 uc009rpr.3 uc009rpr.4 
ENSMUST00000065039.3 Bpi ENSMUST00000065039.3 bactericidal permeablility increasing protein, transcript variant 1 (from RefSeq NM_177850.3) A2AC63 BPI_MOUSE ENSMUST00000065039.1 ENSMUST00000065039.2 NM_177850 Q5I5I4 Q67E05 Q8BSF3 uc008npw.1 uc008npw.2 uc008npw.3 The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Monomer. Homodimer; disulfide-linked. Secreted Cytoplasmic granule membrane Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q67E05-1; Sequence=Displayed; Name=2; IsoId=Q67E05-2; Sequence=VSP_036070; Name=3; IsoId=Q67E05-3; Sequence=VSP_036069; Expressed in testis, epididymis, and bone marrow, as well as in Sertoli and promyelocytic cell lines. Upon stimulation with different TLR ligands, it is strongly expressed in granulocytes and in bone marrow-derived dendritic cells. By lipopolysaccharide (LPS) through TRL4-TRIF-dependent pathway. Expression in Sertoli and promyelocytic cells is enhanced several-fold by all-trans retinoic acid. The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C- terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested. The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues. The 199 N-terminal fragment fused to gas vesicle protein C (gvpC1) of H.salinarum, when incorporated in gas vesicles (GV), increases the survival rate of mice challenged with lethal concentrations of lipopolysaccharide (LPS) and D-galactosamine, if GVs are administered before challenge. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. lipopolysaccharide binding extracellular region extracellular space cytoplasm immune response lipid binding cytoplasmic stress granule membrane antibacterial humoral response lipopolysaccharide-mediated signaling pathway negative regulation of interleukin-6 production negative regulation of interleukin-8 production negative regulation of tumor necrosis factor production defense response to bacterium negative regulation of macrophage activation innate immune response defense response to Gram-negative bacterium cellular response to lipopolysaccharide uc008npw.1 uc008npw.2 uc008npw.3 
ENSMUST00000065060.12 Tmcc3 ENSMUST00000065060.12 transmembrane and coiled coil domains 3, transcript variant 1 (from RefSeq NM_172051.3) ENSMUST00000065060.1 ENSMUST00000065060.10 ENSMUST00000065060.11 ENSMUST00000065060.2 ENSMUST00000065060.3 ENSMUST00000065060.4 ENSMUST00000065060.5 ENSMUST00000065060.6 ENSMUST00000065060.7 ENSMUST00000065060.8 ENSMUST00000065060.9 NM_172051 Q501N6 Q8R310 TMCC3_MOUSE Tmcc3 uc007gvt.1 uc007gvt.2 uc007gvt.3 uc007gvt.4 May form homodimers and heterodimers with TMCC2 or TMCC3 via the coiled-coil domains. Interacts with ribosomal proteins RPL4 and RPS6. Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Concentrates in discrete patches along peripheral endoplasmic reticulum tubules. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R310-1; Sequence=Displayed; Name=2; IsoId=Q8R310-2; Sequence=VSP_025999; At 12.5 dpc, weak expression in the developing lung and hindbrain, high expression in the tongue mesenchyme (PubMed:27697108). At 14.5 dpc, expressed in the trigeminal ganglion, oral epithelium and hindbrain (PubMed:27697108). Also detected in lung, kidney and somites (PubMed:27697108). Belongs to the TEX28 family. endoplasmic reticulum endoplasmic reticulum membrane biological_process membrane integral component of membrane identical protein binding 14-3-3 protein binding uc007gvt.1 uc007gvt.2 uc007gvt.3 uc007gvt.4 
ENSMUST00000065067.14 Prkg1 ENSMUST00000065067.14 protein kinase, cGMP-dependent, type I, transcript variant 3 (from RefSeq NM_001411181.1) ENSMUST00000065067.1 ENSMUST00000065067.10 ENSMUST00000065067.11 ENSMUST00000065067.12 ENSMUST00000065067.13 ENSMUST00000065067.2 ENSMUST00000065067.3 ENSMUST00000065067.4 ENSMUST00000065067.5 ENSMUST00000065067.6 ENSMUST00000065067.7 ENSMUST00000065067.8 ENSMUST00000065067.9 NM_001411181 Prkg1 Q8BND1 Q8BND1_MOUSE uc008hep.1 uc008hep.2 uc008hep.3 uc008hep.4 uc008hep.5 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.12; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.12; Evidence= Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity cGMP-dependent protein kinase activity ATP binding protein phosphorylation kinase activity phosphorylation transferase activity cGMP binding uc008hep.1 uc008hep.2 uc008hep.3 uc008hep.4 uc008hep.5 
ENSMUST00000065080.10 C2cd2l ENSMUST00000065080.10 C2 calcium-dependent domain containing 2-like, transcript variant 1 (from RefSeq NM_027909.2) C2C2L_MOUSE C2cd2l ENSMUST00000065080.1 ENSMUST00000065080.2 ENSMUST00000065080.3 ENSMUST00000065080.4 ENSMUST00000065080.5 ENSMUST00000065080.6 ENSMUST00000065080.7 ENSMUST00000065080.8 ENSMUST00000065080.9 G5E8D9 NM_027909 Q80X80 Tmem24 uc009pct.1 uc009pct.2 uc009pct.3 Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (By similarity). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (By similarity). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (By similarity). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (By similarity). Positively regulates insulin secretion in response to glucose (PubMed:24012759). Phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (By similarity). Homodimer. Endoplasmic reticulum membrane ; Single-pass membrane protein Cell membrane ; Peripheral membrane protein Note=Localizes to sites of contact between the endoplasmic reticulum and the cell membrane. Embedded into the endoplasmic reticulum membrane via its N-terminal transmembrane domain and associates with cell membrane via its C-terminus. In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane and localizes to the reticular endoplasmic reticulum. Reassociates with cell membrane upon dephosphorylation. The SMP-LBD domain is a lipid transport module, which binds glycerolipids with a preference for phosphatidylinositol (PI). Phosphorylation at the C-terminus acidifies the protein and leads to disassociation from the acidic cell membrane. Reassociates with the cell membrane upon dephosphorylation. endoplasmic reticulum endoplasmic reticulum membrane plasma membrane lipid transport lipid binding phosphatidylinositol transporter activity phospholipid transport membrane integral component of membrane cortical endoplasmic reticulum phosphatidylinositol binding positive regulation of insulin secretion involved in cellular response to glucose stimulus insulin binding cytoplasmic side of apical plasma membrane uc009pct.1 uc009pct.2 uc009pct.3 
ENSMUST00000065086.6 Gas1 ENSMUST00000065086.6 Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. (from UniProt Q01721) ENSMUST00000065086.1 ENSMUST00000065086.2 ENSMUST00000065086.3 ENSMUST00000065086.4 ENSMUST00000065086.5 GAS1_MOUSE Gas-1 LF204998 Q01721 uc288nli.1 uc288nli.2 Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. Q01721; Q6AZB0: Boc; NbExp=2; IntAct=EBI-15729104, EBI-15610126; Q01721; Q32MD9: Cdon; NbExp=3; IntAct=EBI-15729104, EBI-7017034; Q01721; Q9BWV1: BOC; Xeno; NbExp=2; IntAct=EBI-15729104, EBI-718555; Q01721; O35158: Cdon; Xeno; NbExp=4; IntAct=EBI-15729104, EBI-7016767; Cell membrane ; Lipid-anchor, GPI- anchor Sequence=CAA46256.1; Type=Erroneous initiation; Evidence=; positive regulation of mesenchymal cell proliferation protein binding plasma membrane cell cycle cell cycle arrest axon guidance positive regulation of cell proliferation regulation of smoothened signaling pathway dorsal/ventral pattern formation negative regulation of protein processing programmed cell death membrane cerebellum morphogenesis dorsal/ventral neural tube patterning negative regulation of cell growth anchored component of membrane outer ear morphogenesis middle ear morphogenesis odontogenesis embryonic digit morphogenesis camera-type eye development negative regulation of apoptotic process cell fate commitment negative regulation of smoothened signaling pathway positive regulation of smoothened signaling pathway negative regulation of mitotic cell cycle anchored component of plasma membrane developmental growth eye morphogenesis embryonic morphogenesis embryonic cranial skeleton morphogenesis embryonic skeletal system development positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation palate development regulation of ER to Golgi vesicle-mediated transport negative regulation of cell cycle G1/S phase transition negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc288nli.1 uc288nli.2 
ENSMUST00000065090.8 Flnc ENSMUST00000065090.8 filamin C, gamma, transcript variant 1 (from RefSeq NM_001081185.2) Abpl B2RY80 B9EKT2 ENSMUST00000065090.1 ENSMUST00000065090.2 ENSMUST00000065090.3 ENSMUST00000065090.4 ENSMUST00000065090.5 ENSMUST00000065090.6 ENSMUST00000065090.7 FLNC_MOUSE Fln2 NM_001081185 Q6PAI6 Q8VHX6 Q9JJ38 uc009bdn.1 uc009bdn.2 uc009bdn.3 Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (By similarity). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (PubMed:16914736). Homodimer; the filamin repeat 24 and the second hinge domain are important for dimer formation (By similarity). Interacts with FLNB, INPPL1, ITGB1A, KCND2, MYOT, MYOZ1 and MYOZ3. Interacts with sarcoglycans SGCD and SGCG. Interacts (via filament repeats 17-18, 20- 21 and 24) with USP25 (isoform USP25m only). Interacts with FBLIM1 (By similarity). Interacts with XIRP1; this interaction is mediated by filamin 20 repeat (By similarity). Interacts with KY. Interacts with IGFN1. Interacts with MICALL2. Interacts with ANK3. Interacts with MICALL2 (By similarity). Interacts with ANK3. Interacts with SYNPO2 (By similarity). Cytoplasm Membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line Note=A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme (By similarity). Targeting to developing and mature Z lines is mediated by the intradomain insert (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=H1; IsoId=Q8VHX6-1; Sequence=Displayed; Name=2; Synonyms=Delta-H1; IsoId=Q8VHX6-2; Sequence=VSP_007580; During myogenesis, isoform 1 is expressed the first day, then is replaced by isoform 2. Ubiquitinated by FBXL22, leading to proteasomal degradation. Belongs to the filamin family. actin binding cytoplasm cytosol cytoskeleton plasma membrane cytoskeletal protein binding actin cytoskeleton membrane sarcoplasm Z disc actin filament-based process ankyrin binding sarcolemma identical protein binding muscle fiber development uc009bdn.1 uc009bdn.2 uc009bdn.3 
ENSMUST00000065103.4 Mrpl35 ENSMUST00000065103.4 mitochondrial ribosomal protein L35 (from RefSeq NM_025430.3) ENSMUST00000065103.1 ENSMUST00000065103.2 ENSMUST00000065103.3 NM_025430 Q9CQL6 RM35_MOUSE uc009chd.1 uc009chd.2 uc009chd.3 uc009chd.4 Mitochondrion Belongs to the bacterial ribosomal protein bL35 family. molecular_function structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation biological_process uc009chd.1 uc009chd.2 uc009chd.3 uc009chd.4 
ENSMUST00000065111.15 Usp45 ENSMUST00000065111.15 ubiquitin specific petidase 45, transcript variant 1 (from RefSeq NM_152825.2) A2AJT1 ENSMUST00000065111.1 ENSMUST00000065111.10 ENSMUST00000065111.11 ENSMUST00000065111.12 ENSMUST00000065111.13 ENSMUST00000065111.14 ENSMUST00000065111.2 ENSMUST00000065111.3 ENSMUST00000065111.4 ENSMUST00000065111.5 ENSMUST00000065111.6 ENSMUST00000065111.7 ENSMUST00000065111.8 ENSMUST00000065111.9 NM_152825 Q8BU19 Q8BZ19 Q8K387 UBP45_MOUSE uc008sda.1 uc008sda.2 uc008sda.3 Catalyzes the deubiquitination of SPDL1 (By similarity). Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (By similarity). May be involved in the maintenance of photoreceptor function (PubMed:30573563). May play a role in normal retinal development (By similarity). Plays a role in cell migration (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with ERCC1 (PubMed:25538220). The catalytically active form interacts with SPDL1 (By similarity). Photoreceptor inner segment Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K387-1; Sequence=Displayed; Name=2; IsoId=Q8K387-2; Sequence=VSP_023794; Retina. Mutant mice generated by CRISPR-Cas9-mediated gene editing show severely reduced scotopic and photopic responses and have significantly fewer green cone photoreceptors compared to wild- type animals. [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the peptidase C19 family. Sequence=BAC29631.1; Type=Erroneous initiation; Evidence=; thiol-dependent ubiquitin-specific protease activity protein binding nucleus cytoplasm DNA repair proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity zinc ion binding protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity metal ion binding uc008sda.1 uc008sda.2 uc008sda.3 
ENSMUST00000065112.7 Adamts15 ENSMUST00000065112.7 ADAM metallopeptidase with thrombospondin type 1 motif 15, transcript variant 3 (from RefSeq NM_001410620.1) ATS15_MOUSE ENSMUST00000065112.1 ENSMUST00000065112.2 ENSMUST00000065112.3 ENSMUST00000065112.4 ENSMUST00000065112.5 ENSMUST00000065112.6 NM_001410620 P59384 Q504Z2 Q91Z56 uc009oqz.1 uc009oqz.2 Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1401-|-1402-Ala' site (PubMed:24220035). Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (PubMed:23233679). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix Cell surface At 10.5 dpc, strongly and specifically expressed in the developing heart tubes (PubMed:24220035). By 13.5 dpc, widely expressed including in the perichondrium in the developing autopod, brain, ear, whisker follicles, vertebral column and epidermis (PubMed:24220035). Also localizes to the myocardium of the developing right atrium, the bulbous cordis and the airway epithelia of the main bronchiole in the lung bud at 11.5 dpc, the vertebral column and dorsal root ganglia at 14.5 dpc, and the developing hind limb at 15.5 dpc (PubMed:24220035). In the adult colon, highly expressed in the muscularis externa (inner circular smooth muscle and outer longitudinal smooth muscle), muscularis mucosa, submucosal glands, crypt, villi epithelial cells, goblet cells and lamina propria (PubMed:24220035). In embryonic skeletal muscle, significantly increased levels between 13.5 dpc and 15.5 dpc with maximal expression observed at 15.5 dpc (PubMed:23233679). Decreased levels in postnatal skeletal muscle (PubMed:23233679). In myoblasts, up-regulated soon after induction of myoblast differentiation (PubMed:23233679). The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Glycosylated (PubMed:24220035). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1- X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively (By similarity). Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL (By similarity). Fucosylation mediates the efficient secretion of ADAMTS family members (By similarity). Can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs (By similarity). Also N- glycosylated (PubMed:24220035). These other glycosylations can also facilitate secretion (By similarity). endopeptidase activity metalloendopeptidase activity extracellular region extracellular space proteolysis heparin binding peptidase activity metallopeptidase activity zinc ion binding cell surface hydrolase activity metal ion binding extracellular matrix binding uc009oqz.1 uc009oqz.2 
ENSMUST00000065118.7 Ube2ql1 ENSMUST00000065118.7 ubiquitin-conjugating enzyme E2Q family-like 1 (from RefSeq NM_001145162.1) E9QMD2 E9QMD2_MOUSE ENSMUST00000065118.1 ENSMUST00000065118.2 ENSMUST00000065118.3 ENSMUST00000065118.4 ENSMUST00000065118.5 ENSMUST00000065118.6 NM_001145162 Ube2ql1 uc007rcp.1 uc007rcp.2 uc007rcp.3 uc007rcp.4 uc007rcp.1 uc007rcp.2 uc007rcp.3 uc007rcp.4 
ENSMUST00000065134.4 Ier5l ENSMUST00000065134.4 immediate early response 5-like (from RefSeq NM_030244.3) ENSMUST00000065134.1 ENSMUST00000065134.2 ENSMUST00000065134.3 IER5L_MOUSE NM_030244 Q8BTA0 Q8CC26 Q99J55 uc008jco.1 uc008jco.2 uc008jco.3 uc008jco.4 Belongs to the IER family. Sequence=BAC25357.1; Type=Frameshift; Evidence=; Sequence=BAC28563.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc008jco.1 uc008jco.2 uc008jco.3 uc008jco.4 
ENSMUST00000065162.11 Fam53a ENSMUST00000065162.11 Belongs to the FAM53 family. (from UniProt E9PV65) AK220276 E9PV65 E9PV65_MOUSE ENSMUST00000065162.1 ENSMUST00000065162.10 ENSMUST00000065162.2 ENSMUST00000065162.3 ENSMUST00000065162.4 ENSMUST00000065162.5 ENSMUST00000065162.6 ENSMUST00000065162.7 ENSMUST00000065162.8 ENSMUST00000065162.9 Fam53a uc290ung.1 uc290ung.2 Belongs to the FAM53 family. uc290ung.1 uc290ung.2 
ENSMUST00000065163.15 Cib1 ENSMUST00000065163.15 calcium and integrin binding 1, transcript variant 1 (from RefSeq NM_011870.6) CIB1_MOUSE Cib ENSMUST00000065163.1 ENSMUST00000065163.10 ENSMUST00000065163.11 ENSMUST00000065163.12 ENSMUST00000065163.13 ENSMUST00000065163.14 ENSMUST00000065163.2 ENSMUST00000065163.3 ENSMUST00000065163.4 ENSMUST00000065163.5 ENSMUST00000065163.6 ENSMUST00000065163.7 ENSMUST00000065163.8 ENSMUST00000065163.9 Kip NM_011870 Prkdcip Q3TN80 Q9Z0F4 uc009hzs.1 uc009hzs.2 uc009hzs.3 uc009hzs.4 Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation- dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells. Monomer. Interacts with the heterodimeric integrin alpha- IIb/beta3 (ITGA2B-ITGB3). Interacts with ITGA2B (via cytoplasmic domain); the interaction is direct and calcium-dependent. Interacts with the protein kinases PLK2/SNK and PRKDC (via the region immediately upstream of the kinase domain). Interacts with PLK3; the interaction inhibits PLK3 kinase activity. Interacts with PSEN2. Interacts (via C- terminus) with F8. Interacts with NBR1 (via C-terminus). Interacts with FEZ1 (via C-terminus). Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation. Interacts with IFI6; the interaction is direct. Interacts with BCL2. Interacts with TAS1R2 (via C-terminus); the interaction is independent of the myristoylation state of CIB1. Interacts with ITPR3; the interaction occurs in a calcium dependent manner. Interacts with PTK2/FAK1. Interacts with MAP3K5; the interaction inhibits MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2. Interacts (via C-terminal region) with STMN2 (via the N-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the STMN2-induced neurite outgrowth inhibition. Interacts with SPHK1, the interaction occurs in a calcium-dependent manner. Interacts with ITGA2B (via C- terminal cytoplasmic tail); the interaction occurs upon platelet aggregation and is stabilized/increased in a calcium and magnesium- dependent manner. Interacts with PAK1 (via N-terminal region); the interaction is direct and occurs in a calcium-dependent manner. Interacts with RAC3 (via C-terminal region); the interaction induces their association with the cytoskeleton upon alpha-IIb/beta3 integrin- mediated adhesion. Interacts with ITGA5 and ITGAV (By similarity). Interacts with MYO1C. Interacts with ITGA2B (via C-terminal cytoplasmic tail region). Interacts (via C-terminal region) with PPP3R1 isoform 1 and isoform 2; the interactions increase upon cardiomyocytes hypertrophy. Interacts with CACNA1C; the interaction increases upon cardiomyocytes hypertrophy. Interacts and forms a complex with TMC6 and TMC8 (By similarity). Membrane ; Lipid- anchor Cell membrane, sarcolemma Cell membrane Apical cell membrane Cell projection, ruffle membrane Cell projection, filopodium tip Cell projection, growth cone Cell projection, lamellipodium Cytoplasm Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, perinuclear region Nucleus Cell projection, neuron projection Perikaryon Note=Colocalized with PPP3R1 at the cell membrane of cardiomyocytes in the hypertrophic heart (By similarity). Colocalized with NBR1 to the perinuclear region. Colocalizes with TAS1R2 in apical regions of taste receptor cells. Colocalized with RAC3 in the perinuclear area and at the cell periphery. Colocalized with PAK1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Redistributed to the cytoskeleton upon platelet aggregation. Translocates from the cytosol to the plasma membrane in a calcium-dependent manner. Colocalized with PLK3 at centrosomes in ductal breast carcinoma cells. Expressed strongly in Sertoli cells, weakly in pachytene spermatocytes, round spermatids and condensing spermatids (at protein level) (PubMed:16982698). Expressed in testis (PubMed:16982698). Expressed in cardiac myocytes and endothelial cells (PubMed:17975111, PubMed:18989529, PubMed:20639889). Expressed in heart, liver, spleen, lung, kidney, brain and inner ear (PubMed:29255404). In the inner ear, expressed in the vestibule, basilar membrane and spiral ganglion cells (PubMed:29255404). Expressed in the heart at 16 dpc (at protein level) (PubMed:20639889). On P7, detected mainly at the apical surface of hair cells (PubMed:16418530). In outer hair cells, it was observed in the kinocilium and in the basal body region at the periphery of the hair cell (PubMed:16418530). Up-regulated upon cardiomyocytes hypertrophy (at protein level). The EF-hands may also bind magnesium ions in the presence of high Mg(2+) levels and low Ca(2+) levels. Mice grow normally and are healthy; other family members (CIB2, CIB3 and CIB4) may probably compensate for CIB1 loss (PubMed:18989529). Males are sterile: spermatogenic cells can complete both mitotic and meiotic divisions, but postmeiotic spermatids do not develop normally and sperm is not produced (PubMed:16982698). Display increased bone marrow megakaryocytes and circulating platelets (PubMed:22128142). Mice display tail bleeding time increase, impaired thrombus formation and angiogenesis defect after ischemia (PubMed:19691476). Show compromised tumor growth (PubMed:20804551). Does not affect auditory function (PubMed:29255404). The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo- CIB (calcium- and magnesium-free form). angiogenesis negative regulation of protein phosphorylation positive regulation of protein phosphorylation positive regulation of cell-matrix adhesion response to ischemia calcium ion binding protein binding nucleus nucleoplasm cytoplasm endoplasmic reticulum centrosome microtubule organizing center cytoskeleton plasma membrane negative regulation of protein kinase activity apoptotic process cellular response to DNA damage stimulus negative regulation of microtubule depolymerization cell cycle endomitotic cell cycle cell adhesion spermatogenesis spermatid development protein C-terminus binding positive regulation of cell proliferation negative regulation of cell proliferation calcium-dependent protein kinase inhibitor activity negative regulation of neuron projection development membrane apical plasma membrane Ras GTPase binding protein kinase binding lamellipodium cell differentiation platelet formation protein serine/threonine kinase inhibitor activity positive regulation of cell growth positive regulation of cell migration axon dendrite growth cone cytoplasmic microtubule organization filopodium tip ruffle membrane positive regulation of cell adhesion mediated by integrin thrombopoietin-mediated signaling pathway regulation of cell proliferation sarcolemma cell projection neuron projection neuronal cell body negative regulation of apoptotic process positive regulation of catalytic activity protein anchor ion channel binding negative regulation of megakaryocyte differentiation metal ion binding perinuclear region of cytoplasm positive regulation of NF-kappaB transcription factor activity cell division regulation of cell division negative regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade positive regulation of calcineurin-NFAT signaling cascade cellular response to tumor necrosis factor cellular response to growth factor stimulus negative regulation of protein serine/threonine kinase activity positive regulation of protein serine/threonine kinase activity cell periphery positive regulation of cell migration involved in sprouting angiogenesis positive regulation of protein targeting to membrane positive regulation of substrate adhesion-dependent cell spreading positive regulation of protein localization to plasma membrane cellular response to nerve growth factor stimulus positive regulation of male germ cell proliferation uc009hzs.1 uc009hzs.2 uc009hzs.3 uc009hzs.4 
ENSMUST00000065167.9 Grk3 ENSMUST00000065167.9 G protein-coupled receptor kinase 3, transcript variant 1 (from RefSeq NM_177078.4) ARBK2_MOUSE Adrbk2 ENSMUST00000065167.1 ENSMUST00000065167.2 ENSMUST00000065167.3 ENSMUST00000065167.4 ENSMUST00000065167.5 ENSMUST00000065167.6 ENSMUST00000065167.7 ENSMUST00000065167.8 F8VPM8 Grk3 NM_177078 Q3UYH7 uc008ytt.1 uc008ytt.2 uc008ytt.3 uc008ytt.4 Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. Reaction=[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]- phosphate + ADP + H(+); Xref=Rhea:RHEA:19429, Rhea:RHEA-COMP:11222, Rhea:RHEA-COMP:11223, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19430; Evidence=; Interacts with GIT1. Postsynapse Presynapse Ubiquitinated. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. nucleotide binding positive regulation of protein phosphorylation desensitization of G-protein coupled receptor protein signaling pathway protein kinase activity protein serine/threonine kinase activity G-protein coupled receptor kinase activity ATP binding nucleus cytosol cilium protein phosphorylation intracellular protein transport signal transduction membrane kinase activity phosphorylation transferase activity Z disc axon receptor internalization D1 dopamine receptor binding dendritic spine dendritic shaft inositol phosphate metabolic process dendrite terminus membrane raft synapse rhodopsin metabolic process beta-adrenergic receptor kinase activity perinuclear region of cytoplasm sperm midpiece uc008ytt.1 uc008ytt.2 uc008ytt.3 uc008ytt.4 
ENSMUST00000065169.12 Gatad2a ENSMUST00000065169.12 GATA zinc finger domain containing 2A, transcript variant 1 (from RefSeq NM_145596.4) E9QMN5 E9QMN5_MOUSE ENSMUST00000065169.1 ENSMUST00000065169.10 ENSMUST00000065169.11 ENSMUST00000065169.2 ENSMUST00000065169.3 ENSMUST00000065169.4 ENSMUST00000065169.5 ENSMUST00000065169.6 ENSMUST00000065169.7 ENSMUST00000065169.8 ENSMUST00000065169.9 Gatad2a NM_145596 uc009lyg.1 uc009lyg.2 uc009lyg.3 uc009lyg.4 uc009lyg.5 Nucleus negative regulation of transcription from RNA polymerase II promoter nucleus nucleoplasm NuRD complex protein binding, bridging negative regulation of transcription, DNA-templated uc009lyg.1 uc009lyg.2 uc009lyg.3 uc009lyg.4 uc009lyg.5 
ENSMUST00000065196.13 Scn5a ENSMUST00000065196.13 sodium channel, voltage-gated, type V, alpha, transcript variant 2 (from RefSeq NM_001253860.1) ENSMUST00000065196.1 ENSMUST00000065196.10 ENSMUST00000065196.11 ENSMUST00000065196.12 ENSMUST00000065196.2 ENSMUST00000065196.3 ENSMUST00000065196.4 ENSMUST00000065196.5 ENSMUST00000065196.6 ENSMUST00000065196.7 ENSMUST00000065196.8 ENSMUST00000065196.9 K3W4N7 K3W4N7_MOUSE NM_001253860 Scn5a uc009sbe.1 uc009sbe.2 uc009sbe.3 Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the sodium channel (TC 1.A.1.10) family. Lacks conserved residue(s) required for the propagation of feature annotation. voltage-gated sodium channel complex ion channel activity voltage-gated ion channel activity voltage-gated sodium channel activity sodium channel activity plasma membrane ion transport sodium ion transport membrane integral component of membrane ion transmembrane transport regulation of ion transmembrane transport sodium ion transmembrane transport transmembrane transport uc009sbe.1 uc009sbe.2 uc009sbe.3 
ENSMUST00000065204.8 Kcnk18 ENSMUST00000065204.8 potassium channel, subfamily K, member 18 (from RefSeq NM_207261.3) ENSMUST00000065204.1 ENSMUST00000065204.2 ENSMUST00000065204.3 ENSMUST00000065204.4 ENSMUST00000065204.5 ENSMUST00000065204.6 ENSMUST00000065204.7 KCNKI_MOUSE NM_207261 Q1LZJ5 Q1LZM8 Q3MI50 Q3MI51 Q6VV64 Tresk-2 Tresk2 uc008ibh.1 uc008ibh.2 uc008ibh.3 Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3- 3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation. Interacts with calcineurin. Interacts with YWHAH, in a phosphorylation-dependent manner. Cell membrane ; Multi-pass membrane protein Detected in brain cortex, cerebellum, dorsal root ganglion, spinal cord and testis. High expression in trigeminal ganglion, also expressed in autonomic nervous system ganglia such as the stellate ganglion and paravertebral sympathetic ganglia. Expressed in all adult spinal cord and brain regions, with slightly higher expression in thalamus, hypothalamus, hippocampus and posterior corte (at protein level). In non-neuronal tissues, substantial expression found in lung and heart and weal expression in liver, testis, kidney, small intestine and spleen. Expression appears in trigeminal ganglion and dorsal root ganglia from 15.5 dpc and increased through 18 dpc to reach a peak in newborn mouse postnatal day 1. Phosphorylation of Ser-264 is required for the binding of 14-3- 3eta/YWHAH. Calcineurin-mediated dephosphorylation of Ser-276 enhances channel activity. N-glycosylated. Regulated by extracellular protons whereas human ortholog is not. His-132 is responsible for proton-dependent specific activity. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. Name=Protein Spotlight; Note=Throb - Issue 124 of December 2010; URL="https://web.expasy.org/spotlight/back_issues/124"; potassium channel activity protein binding plasma membrane integral component of plasma membrane ion transport potassium ion transport calcium-activated potassium channel activity outward rectifier potassium channel activity membrane integral component of membrane potassium ion leak channel activity stabilization of membrane potential cellular response to pH potassium ion transmembrane transport potassium ion export across plasma membrane uc008ibh.1 uc008ibh.2 uc008ibh.3 
ENSMUST00000065211.9 Srr ENSMUST00000065211.9 serine racemase, transcript variant 1 (from RefSeq NM_013761.5) ENSMUST00000065211.1 ENSMUST00000065211.2 ENSMUST00000065211.3 ENSMUST00000065211.4 ENSMUST00000065211.5 ENSMUST00000065211.6 ENSMUST00000065211.7 ENSMUST00000065211.8 NM_013761 Q401M7 Q5SWE4 Q5SWE5 Q5SWE7 Q8BT19 Q8CD11 Q9QZX7 SRR_MOUSE uc007kcr.1 uc007kcr.2 uc007kcr.3 Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. Reaction=L-serine = D-serine; Xref=Rhea:RHEA:10980, ChEBI:CHEBI:33384, ChEBI:CHEBI:35247; EC=5.1.1.18; Evidence= Reaction=D-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:13977, ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:35247; EC=4.3.1.18; Evidence=; Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169, ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17; Evidence= Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Homodimer. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9QZX7-1; Sequence=Displayed; Name=2; IsoId=Q9QZX7-2; Sequence=VSP_025013; Name=3; IsoId=Q9QZX7-3; Sequence=VSP_025014; Detected in brain (at protein level). Brain. S-nitrosylated, leading to decrease the enzyme activity. Belongs to the serine/threonine dehydratase family. Sequence=CAI24255.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding magnesium ion binding catalytic activity L-serine ammonia-lyase activity calcium ion binding protein binding ATP binding cytoplasm plasma membrane cellular amino acid metabolic process L-serine metabolic process brain development aging metabolic process D-serine ammonia-lyase activity serine family amino acid metabolic process response to organic cyclic compound glycine binding lyase activity isomerase activity threonine racemase activity PDZ domain binding pyridoxal phosphate binding serine racemase activity response to lipopolysaccharide response to drug identical protein binding protein homodimerization activity pyruvate biosynthetic process neuronal cell body response to morphine apical part of cell metal ion binding D-serine metabolic process D-serine biosynthetic process uc007kcr.1 uc007kcr.2 uc007kcr.3 
ENSMUST00000065213.5 Rnf222 ENSMUST00000065213.5 ring finger protein 222 (from RefSeq NM_177060.3) B1ARA2 ENSMUST00000065213.1 ENSMUST00000065213.2 ENSMUST00000065213.3 ENSMUST00000065213.4 NM_177060 Q8CEF8 RN222_MOUSE uc007jog.1 uc007jog.2 uc007jog.3 Membrane ; Single-pass membrane protein membrane integral component of membrane metal ion binding uc007jog.1 uc007jog.2 uc007jog.3 
ENSMUST00000065216.11 Spink2 ENSMUST00000065216.11 serine peptidase inhibitor, Kazal type 2, transcript variant 2 (from RefSeq NM_183284.3) D3Z3X9 ENSMUST00000065216.1 ENSMUST00000065216.10 ENSMUST00000065216.2 ENSMUST00000065216.3 ENSMUST00000065216.4 ENSMUST00000065216.5 ENSMUST00000065216.6 ENSMUST00000065216.7 ENSMUST00000065216.8 ENSMUST00000065216.9 ISK2_MOUSE NM_183284 Q5M8S4 Q8BMY7 uc008xvx.1 uc008xvx.2 uc008xvx.3 uc008xvx.4 As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:21705336, PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (PubMed:21705336). It also inhibits trypsin (PubMed:21705336). Secreted Cytoplasmic vesicle, secretory vesicle, acrosome Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=Q8BMY7-1; Sequence=Displayed; Name=2; IsoId=Q8BMY7-2; Sequence=VSP_060766; Expressed in sperm (at protein level). Expressed in testis but not in ovary, brain, heart, kidney or lung. Within testis, expressed in epididymis and germ cells. First expressed at 16 days postpartum (dpp). Level increases until 20 dpp and is maintained into adulthood (at protein level). Knockout male mice are completely infertile, whereas no reproductive defects are observed in females. Spermatozoa are completely absent from caudal epididymis, which only contains round cells likely corresponding to round spermatids and multinucleated cells. Seminiferous tubules contain germ cells up to the early round- spermatid stage but condensed and elongated spermatids and mature spermatozoa are completely absent. Round spermatids do not contain an acrosomal vesicle. On the 2D-gel the determined pI of this protein is: 5, its MW is: 8 kDa. acrosomal vesicle acrosome assembly male germ cell proliferation serine-type endopeptidase inhibitor activity extracellular region cytoplasm apoptotic process spermatogenesis spermatid development male gonad development fertilization negative regulation of peptidase activity cell differentiation peptidase inhibitor activity cytoplasmic vesicle neuron projection positive regulation of apoptotic process seminiferous tubule development negative regulation of serine-type endopeptidase activity uc008xvx.1 uc008xvx.2 uc008xvx.3 uc008xvx.4 
ENSMUST00000065224.8 Galr1 ENSMUST00000065224.8 galanin receptor 1 (from RefSeq NM_008082.2) ENSMUST00000065224.1 ENSMUST00000065224.2 ENSMUST00000065224.3 ENSMUST00000065224.4 ENSMUST00000065224.5 ENSMUST00000065224.6 ENSMUST00000065224.7 GALR1_MOUSE Galnr Galnr1 NM_008082 P56479 uc008ftq.1 uc008ftq.2 uc008ftq.3 Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Interacts with GRP39 AND HTR1A. Cell membrane ; Multi-pass membrane protein. Expression is detected in brain, spinal cord, heart and skeletal muscle. Three cysteine residues are found in the C-terminus, at least one of which may be palmitoylated. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity galanin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane peptide hormone binding neuropeptide binding positive regulation of transcription from RNA polymerase II promoter positive regulation of cortisol secretion uc008ftq.1 uc008ftq.2 uc008ftq.3 
ENSMUST00000065248.9 Cd8b1 ENSMUST00000065248.9 CD8 subunit beta 1 (from RefSeq NM_009858.3) Cd8b1 ENSMUST00000065248.1 ENSMUST00000065248.2 ENSMUST00000065248.3 ENSMUST00000065248.4 ENSMUST00000065248.5 ENSMUST00000065248.6 ENSMUST00000065248.7 ENSMUST00000065248.8 NM_009858 Q3TEK8 Q3TEK8_MOUSE uc009cgp.1 uc009cgp.2 uc009cgp.3 Membrane ; Single- pass type I membrane protein coreceptor activity membrane integral component of membrane MHC class I protein binding regulation of immune response uc009cgp.1 uc009cgp.2 uc009cgp.3 
ENSMUST00000065263.12 Sbno1 ENSMUST00000065263.12 strawberry notch 1, transcript variant 2 (from RefSeq NM_001081203.2) B2RRI2 B2RRI2_MOUSE ENSMUST00000065263.1 ENSMUST00000065263.10 ENSMUST00000065263.11 ENSMUST00000065263.2 ENSMUST00000065263.3 ENSMUST00000065263.4 ENSMUST00000065263.5 ENSMUST00000065263.6 ENSMUST00000065263.7 ENSMUST00000065263.8 ENSMUST00000065263.9 NM_001081203 Sbno1 uc008zpq.1 uc008zpq.2 Belongs to the SBNO family. regulation of transcription, DNA-templated uc008zpq.1 uc008zpq.2 
ENSMUST00000065286.2 Fam204a ENSMUST00000065286.2 family with sequence similarity 204, member A, transcript variant 1 (from RefSeq NM_029648.7) D19Ertd737e ENSMUST00000065286.1 F204A_MOUSE NM_029648 Q8C6C7 uc008ibr.1 uc008ibr.2 molecular_function cellular_component biological_process uc008ibr.1 uc008ibr.2 
ENSMUST00000065289.6 Clec12a ENSMUST00000065289.6 C-type lectin domain family 12, member a (from RefSeq NM_177686.4) A0A0R4J0T2 A0A0R4J0T2_MOUSE Clec12a ENSMUST00000065289.1 ENSMUST00000065289.2 ENSMUST00000065289.3 ENSMUST00000065289.4 ENSMUST00000065289.5 NM_177686 uc009efl.1 uc009efl.2 uc009efl.3 uc009efl.4 Membrane ; Single- pass type II membrane protein membrane integral component of membrane carbohydrate binding uc009efl.1 uc009efl.2 uc009efl.3 uc009efl.4 
ENSMUST00000065291.2 Cfap300 ENSMUST00000065291.2 cilia and flagella associated protein 300, transcript variant 1 (from RefSeq NM_199017.3) CF300_MOUSE Cfap300 ENSMUST00000065291.1 NM_199017 Q8CC70 uc009odh.1 uc009odh.2 Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly. Interacts with DNAAF2. Cytoplasm Cytoplasm, cytoskeleton, cilium axoneme Expressed in the left-right organiser (LRO) node at 8.25 dpc. Belongs to the CFAP300 family. molecular_function cellular_component cytoplasm cytoskeleton biological_process motile cilium cell projection uc009odh.1 uc009odh.2 
ENSMUST00000065308.13 Azin1 ENSMUST00000065308.13 antizyme inhibitor 1, transcript variant 2 (from RefSeq NM_018745.5) AZIN1_MOUSE ENSMUST00000065308.1 ENSMUST00000065308.10 ENSMUST00000065308.11 ENSMUST00000065308.12 ENSMUST00000065308.2 ENSMUST00000065308.3 ENSMUST00000065308.4 ENSMUST00000065308.5 ENSMUST00000065308.6 ENSMUST00000065308.7 ENSMUST00000065308.8 ENSMUST00000065308.9 NM_018745 O35484 Oazi Oazin Q542G5 Q8C2R8 Q8K1E5 uc007vnt.1 uc007vnt.2 uc007vnt.3 The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]. Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:16916800, PubMed:18062773, PubMed:18508777). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:10698696, PubMed:18062773, PubMed:18369191). Monomer (PubMed:18369191). Interacts with OAZ1 and OAZ3; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:18062773, PubMed:18369191). Nucleus Expressed during testis development. Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1. Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily. catalytic activity ornithine decarboxylase activity nucleus cytoplasm polyamine metabolic process polyamine biosynthetic process putrescine biosynthetic process from ornithine negative regulation of protein catabolic process ornithine decarboxylase activator activity positive regulation of catalytic activity positive regulation of polyamine transmembrane transport uc007vnt.1 uc007vnt.2 uc007vnt.3 
ENSMUST00000065329.13 Tmem248 ENSMUST00000065329.13 transmembrane protein 248, transcript variant 2 (from RefSeq NM_001081394.1) ENSMUST00000065329.1 ENSMUST00000065329.10 ENSMUST00000065329.11 ENSMUST00000065329.12 ENSMUST00000065329.2 ENSMUST00000065329.3 ENSMUST00000065329.4 ENSMUST00000065329.5 ENSMUST00000065329.6 ENSMUST00000065329.7 ENSMUST00000065329.8 ENSMUST00000065329.9 NM_001081394 Q3TBN1 Q8CIB2 Q9DD07 TM248_MOUSE uc008zuh.1 uc008zuh.2 Membrane ; Multi-pass membrane protein Belongs to the TMEM248 family. Sequence=BAB21996.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008zuh.1 uc008zuh.2 
ENSMUST00000065330.8 Clk3 ENSMUST00000065330.8 CDC-like kinase 3, transcript variant 1 (from RefSeq NM_007713.5) A0A8Z1S2G3 A0A8Z1S2G3_MOUSE Clk3 ENSMUST00000065330.1 ENSMUST00000065330.2 ENSMUST00000065330.3 ENSMUST00000065330.4 ENSMUST00000065330.5 ENSMUST00000065330.6 ENSMUST00000065330.7 NM_007713 mCG_9314 uc009pvr.1 uc009pvr.2 uc009pvr.3 Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. uc009pvr.1 uc009pvr.2 uc009pvr.3 
ENSMUST00000065335.3 Gpr141 ENSMUST00000065335.3 G protein-coupled receptor 141 (from RefSeq NM_181754.4) ENSMUST00000065335.1 ENSMUST00000065335.2 GP141_MOUSE NM_181754 Pgr13 Q059N8 Q7TQP0 Q80UC5 uc007ppl.1 uc007ppl.2 Orphan receptor. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc007ppl.1 uc007ppl.2 
ENSMUST00000065358.9 Commd4 ENSMUST00000065358.9 COMM domain containing 4 (from RefSeq NM_025417.2) COMD4_MOUSE ENSMUST00000065358.1 ENSMUST00000065358.2 ENSMUST00000065358.3 ENSMUST00000065358.4 ENSMUST00000065358.5 ENSMUST00000065358.6 ENSMUST00000065358.7 ENSMUST00000065358.8 NM_025417 Q9CQ02 uc009pul.1 uc009pul.2 uc009pul.3 May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL5, CUL7. Cytoplasm Nucleus molecular_function nucleus cytoplasm biological_process uc009pul.1 uc009pul.2 uc009pul.3 
ENSMUST00000065359.12 Fank1 ENSMUST00000065359.12 fibronectin type 3 and ankyrin repeat domains 1, transcript variant 1 (from RefSeq NM_025850.3) ENSMUST00000065359.1 ENSMUST00000065359.10 ENSMUST00000065359.11 ENSMUST00000065359.2 ENSMUST00000065359.3 ENSMUST00000065359.4 ENSMUST00000065359.5 ENSMUST00000065359.6 ENSMUST00000065359.7 ENSMUST00000065359.8 ENSMUST00000065359.9 FANK1_MOUSE Fank1 NM_025850 Q9CUA7 Q9DAM9 uc009kdn.1 uc009kdn.2 uc009kdn.3 Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis. Interacts with COPS5; regulates the phosphorylation of JUN and the transcriptional activity of AP-1. Interacts with RYBP; may prevent the ubiquitin-mediated proteasomal degradation of FANK1. Nucleus Cytoplasm, cytosol Cytoplasm, cytoskeleton, cilium basal body Cell projection, cilium Note=Weakly detected in the cytoplasm of elongated spermatids. Mostly restricted to testis (at protein level), including mid to late pachytene spermatocytes (stages VI-X), diplotene spermatocytes (stage XI), meiotically dividing spermatocytes (stage XII) and spermatids in steps 1-14. Highest levels in late pachytene spermatocytes and spermatids in steps 1-9. In the developing testis, first detected at postnatal day 14 (P14) and levels increase after P20 (at protein level). At P20, detected in pachytene spermatocytes and round spermatids, but not in preleptotene and leptotene spermatocytes. Not detected in testis at P10. Detected in germinal vesicle (GV) stage oocytes and in embryos up to the 2-cell stage, but not in morula or blastocysts. Expression is activated by FOXJ1. The fibronectin type-III domain mediates interaction with COPS5 and RYBP. Polyubiquitinated. Polyubiquitination leads to proteasomal degradation. chromatin molecular_function nucleus nucleoplasm cytoplasm cytosol cytoskeleton cilium ciliary basal body cell projection positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of transcription, DNA-templated positive regulation of sequence-specific DNA binding transcription factor activity ciliary base uc009kdn.1 uc009kdn.2 uc009kdn.3 
ENSMUST00000065364.5 Chmp3 ENSMUST00000065364.5 charged multivesicular body protein 3, transcript variant 4 (from RefSeq NM_001361405.1) CHMP3_MOUSE ENSMUST00000065364.1 ENSMUST00000065364.2 ENSMUST00000065364.3 ENSMUST00000065364.4 NM_001361405 Q9CQ10 Q9D2Z2 Q9D7A5 Vps24 uc009cgx.1 uc009cgx.2 uc009cgx.3 Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity). Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Forms a metastable monomer in solution; its core structure (without part of the putative autoinhibitory C-terminal acidic region) oligomerizes into a flat lattice via two different dimerization interfaces. In vitro, heteromerizes with CHMP2A (but not CHMP4) to form helical tubular structures that expose membrane- interacting sites on the outside whereas VPS4B can associate on the inside of the tubule. May interact with IGFBP7; the relevance of such interaction however remains unclear. Interacts with CHMP2A. Interacts with CHMP4A; the interaction requires the release of CHMP4A autoinhibition. Interacts with VPS4A. Interacts with STAMBP; the interaction appears to relieve the autoinhibition of CHMP3 (By similarity). Interacts with VTA1 (By similarity). Cytoplasm, cytosol Membrane ; Lipid-anchor Endosome Late endosome membrane Note=Localizes to the midbody of dividing cells. Expressed in lung, testis, heart, spleen, skeletal muscle, kidney, liver and brain. The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components. Belongs to the SNF7 family. ESCRT III complex phosphatidylinositol-4,5-bisphosphate binding cytoplasm endosome early endosome late endosome multivesicular body cytosol plasma membrane vacuolar transport cell cycle endosome to lysosome transport regulation of centrosome duplication protein transport membrane midbody phosphatidylcholine binding cytoplasmic vesicle late endosome membrane positive regulation of cytokinesis endosome transport via multivesicular body sorting pathway viral budding via host ESCRT complex identical protein binding protein homodimerization activity late endosome to vacuole transport regulation of viral process regulation of endosome size protein polymerization protein heterooligomerization cell division multivesicular body-lysosome fusion negative regulation of viral release from host cell positive regulation of viral release from host cell ubiquitin-specific protease binding regulation of early endosome to late endosome transport uc009cgx.1 uc009cgx.2 uc009cgx.3 
ENSMUST00000065373.6 Tmem70 ENSMUST00000065373.6 transmembrane protein 70, transcript variant 1 (from RefSeq NM_027415.2) ENSMUST00000065373.1 ENSMUST00000065373.2 ENSMUST00000065373.3 ENSMUST00000065373.4 ENSMUST00000065373.5 NM_027415 Q3TKB6 Q3UAP8 Q921N7 Q9CQY4 Q9D7R8 TMM70_MOUSE Tmem70 uc007ajy.1 uc007ajy.2 uc007ajy.3 Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction (By similarity). Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis (PubMed:31652072, PubMed:28173120). In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies (By similarity). Homooligomer. Interacts (homooligomer form) with ATP5MC1; this interaction facilitates the oligomer formation of subunit c/ATP5MC1 (c- ring) and the c-ring membrane insertion and also protects ATP5MC1 against intramitochondrial proteolysis. Interacts with the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 of the MCIA complex. Interacts with ATP5MC3, TMEM242 and TIMMDC1. Mitochondrion inner membrane ; Multi-pass membrane protein Note=Mostly located within the inner cristae membrane. Higher expressed in the heart than in the liver (at protein level). Homozygous knockout mice for Tmem70 are embryonically lethal at about 9.5 days post coitum and exhibit profound growth retardation (PubMed:28173120). Embryos exhibit delayed development of the cardiovascular system and a disturbed heart mitochondrial ultrastructure, with concentric or irregular cristae structures (PubMed:28173120). Belongs to the TMEM70 family. Sequence=BAB25987.1; Type=Frameshift; Evidence=; molecular_function nucleoplasm mitochondrion mitochondrial inner membrane membrane integral component of membrane integral component of mitochondrial membrane mitochondrial proton-transporting ATP synthase complex assembly uc007ajy.1 uc007ajy.2 uc007ajy.3 
ENSMUST00000065382.6 Gsx1 ENSMUST00000065382.6 GS homeobox 1 (from RefSeq NM_008178.3) ENSMUST00000065382.1 ENSMUST00000065382.2 ENSMUST00000065382.3 ENSMUST00000065382.4 ENSMUST00000065382.5 GSX1_MOUSE Gsh-1 Gsh1 NM_008178 P31315 uc009anw.1 uc009anw.2 uc009anw.3 Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development. Nucleus. Belongs to the Antp homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development central nervous system development spinal cord association neuron differentiation hypothalamus development adenohypophysis development neuron differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter neuron fate commitment uc009anw.1 uc009anw.2 uc009anw.3 
ENSMUST00000065388.11 Supt7l ENSMUST00000065388.11 SPT7-like, STAGA complex gamma subunit (from RefSeq NM_028150.2) ENSMUST00000065388.1 ENSMUST00000065388.10 ENSMUST00000065388.2 ENSMUST00000065388.3 ENSMUST00000065388.4 ENSMUST00000065388.5 ENSMUST00000065388.6 ENSMUST00000065388.7 ENSMUST00000065388.8 ENSMUST00000065388.9 NM_028150 Q9CZV5 ST65G_MOUSE uc008wyj.1 uc008wyj.2 uc008wyj.3 uc008wyj.4 Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, SUPT7L, GCN5L2, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12 and TAF9. Nucleus Sumoylated. transcription coactivator activity histone acetyltransferase activity nucleus nucleoplasm STAGA complex histone H3 acetylation protein heterodimerization activity maintenance of protein location in nucleus positive regulation of nucleic acid-templated transcription uc008wyj.1 uc008wyj.2 uc008wyj.3 uc008wyj.4 
ENSMUST00000065398.13 Nup214 ENSMUST00000065398.13 nucleoporin 214, transcript variant 1 (from RefSeq NM_172268.3) A2ATN2 ENSMUST00000065398.1 ENSMUST00000065398.10 ENSMUST00000065398.11 ENSMUST00000065398.12 ENSMUST00000065398.2 ENSMUST00000065398.3 ENSMUST00000065398.4 ENSMUST00000065398.5 ENSMUST00000065398.6 ENSMUST00000065398.7 ENSMUST00000065398.8 ENSMUST00000065398.9 Kiaa0023 NM_172268 NU214_MOUSE Q80U93 uc008jeh.1 uc008jeh.2 uc008jeh.3 Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. Homodimer. Part of the nuclear pore complex (NPC). Interacts with NUP88. Interacts with ZFP36; this interaction increases upon lipopolysaccharide (LPS) stimulation. Interacts with DDX19. Interacts with XPO1. Interacts with XPO5. Nucleus, nuclear pore complex Note=Cytoplasmic side of the nuclear pore complex. Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B. Probably glycosylated as it reacts with wheat germ agglutinin (WGA). Sequence=BAC65471.1; Type=Erroneous initiation; Evidence=; mitotic cell cycle nuclear export signal receptor activity nucleus nuclear envelope nuclear pore focal adhesion mRNA export from nucleus protein import into nucleus protein export from nucleus nuclear localization sequence binding protein transport structural constituent of nuclear pore intracellular membrane-bounded organelle regulation of nucleocytoplasmic transport mRNA transport regulation of cell cycle cytoplasmic side of nuclear pore uc008jeh.1 uc008jeh.2 uc008jeh.3 
ENSMUST00000065403.7 Daw1 ENSMUST00000065403.7 dynein assembly factor with WDR repeat domains 1, transcript variant 7 (from RefSeq NR_164165.1) D3Z7A5 DAW1_MOUSE Daw1 ENSMUST00000065403.1 ENSMUST00000065403.2 ENSMUST00000065403.3 ENSMUST00000065403.4 ENSMUST00000065403.5 ENSMUST00000065403.6 NR_164165 Wdr69 uc287jts.1 uc287jts.2 Required for axonemal dynein assembly and ciliary motility in ciliated organs, including Kupffer's vesicle, during embryogenesis (By similarity). Facilitates the onset of robust cilia motility during development (By similarity). Interacts with IFT46. Cytoplasm, cytoskeleton, flagellum basal body Cytoplasm, cytoskeleton, flagellum axoneme Note=Expression is concentrated at the flagellum basal body but is also detected along the length of the flagellum. In early mouse embryos, expression is limited to distal, motile ciliated cells of the node. Belongs to the WD repeat WDR69 family. epithelial cilium movement molecular_function extracellular region determination of left/right symmetry heart development outer dynein arm assembly cerebrospinal fluid circulation uc287jts.1 uc287jts.2 
ENSMUST00000065408.16 Ly6c1 ENSMUST00000065408.16 lymphocyte antigen 6 family member C1, transcript variant 1 (from RefSeq NM_010741.4) ENSMUST00000065408.1 ENSMUST00000065408.10 ENSMUST00000065408.11 ENSMUST00000065408.12 ENSMUST00000065408.13 ENSMUST00000065408.14 ENSMUST00000065408.15 ENSMUST00000065408.2 ENSMUST00000065408.3 ENSMUST00000065408.4 ENSMUST00000065408.5 ENSMUST00000065408.6 ENSMUST00000065408.7 ENSMUST00000065408.8 ENSMUST00000065408.9 LY6C1_MOUSE NM_010741 P09568 P0CW02 Q58E40 Q8C2D8 Q91XG0 uc007wgn.1 uc007wgn.2 uc007wgn.3 uc007wgn.4 uc007wgn.5 Cell membrane ; Lipid-anchor, GPI- anchor plasma membrane external side of plasma membrane cell surface membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway negative regulation of receptor activity uc007wgn.1 uc007wgn.2 uc007wgn.3 uc007wgn.4 uc007wgn.5 
ENSMUST00000065417.15 Ly6h ENSMUST00000065417.15 lymphocyte antigen 6 family member H, transcript variant 6 (from RefSeq NM_001411858.1) ENSMUST00000065417.1 ENSMUST00000065417.10 ENSMUST00000065417.11 ENSMUST00000065417.12 ENSMUST00000065417.13 ENSMUST00000065417.14 ENSMUST00000065417.2 ENSMUST00000065417.3 ENSMUST00000065417.4 ENSMUST00000065417.5 ENSMUST00000065417.6 ENSMUST00000065417.7 ENSMUST00000065417.8 ENSMUST00000065417.9 LY6H_MOUSE NM_001411858 Q9WUC3 uc011zul.1 uc011zul.2 Believed to act as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response (PubMed:26276394). May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface (PubMed:25716842). Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons (By similarity). Interacts with CHRNA4 and CHRNA7. Cell membrane ; Lipid-anchor, GPI- anchor Strongly expressed in brain, also found in lower levels in eye and reproductive tissues. Expression increases during embryonic development. It is uncertain whether Met-1 or Met-6 is the initiator. Sequence=AAD28600.1; Type=Erroneous initiation; Evidence=; plasma membrane membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway negative regulation of receptor activity uc011zul.1 uc011zul.2 
ENSMUST00000065418.7 Rab13 ENSMUST00000065418.7 RAB13, member RAS oncogene family, transcript variant 1 (from RefSeq NM_026677.4) ENSMUST00000065418.1 ENSMUST00000065418.2 ENSMUST00000065418.3 ENSMUST00000065418.4 ENSMUST00000065418.5 ENSMUST00000065418.6 NM_026677 Q9DD03 RAB13_MOUSE uc008qbn.1 uc008qbn.2 uc008qbn.3 uc008qbn.4 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). That Rab may be activated by DENND1C, a guanine exchange factor. Activated in response to insulin (By similarity). Interacts (GTP-bound form) with MICALL2; competes with RAB8A and is involved in tight junctions assembly. Interacts (GTP-bound form) with MICALL1. Interacts (GTP-bound form) with MICAL1, MICAL3, MICALCL, EHBP1 and EHBP1L1; ternary complexes of RAB8A, RAB13 and either MICAL1 or EHBP1L1 are possible. Interacts with PRKACA; downstream effector of RAB13 involved in tight junction assembly. Interacts with GRB2; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA. Interacts (isoprenylated form) with PDE6D; dissociates RAB13 from membranes. Interacts with BICDL2/BICDR2. Interacts with LEPROT and LEPROTL1. Cell membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasmic vesicle membrane ; Lipid-anchor ; Cytoplasmic side Cell junction, tight junction Golgi apparatus, trans-Golgi network membrane Recycling endosome membrane Cell projection, lamellipodium Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (By similarity). Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (PubMed:21543326). Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity GTP binding endosome Golgi apparatus trans-Golgi network cytosol plasma membrane cell-cell junction bicellular tight junction intracellular protein transport vesicle docking involved in exocytosis synaptic vesicle protein secretion protein kinase A signaling protein transport membrane endosomal transport lateral plasma membrane regulation of exocytosis extrinsic component of plasma membrane lamellipodium cell junction endocytic vesicle trans-Golgi network transport vesicle cytoplasmic vesicle membrane cortical actin cytoskeleton organization neuron projection development cytoplasmic vesicle endocytic recycling Rab protein signal transduction insulin-responsive compartment cellular response to insulin stimulus protein kinase A catalytic subunit binding endothelial cell chemotaxis cell projection neuron projection trans-Golgi network to recycling endosome transport Golgi vesicle fusion to target membrane recycling endosome recycling endosome membrane bicellular tight junction assembly protein localization to plasma membrane establishment of Sertoli cell barrier protein localization to cell leading edge uc008qbn.1 uc008qbn.2 uc008qbn.3 uc008qbn.4 
ENSMUST00000065420.12 Hjurp ENSMUST00000065420.12 RIKEN cDNA A730008H23 gene (from RefSeq NM_172505.5) E9Q4T0 E9Q4T0_MOUSE ENSMUST00000065420.1 ENSMUST00000065420.10 ENSMUST00000065420.11 ENSMUST00000065420.2 ENSMUST00000065420.3 ENSMUST00000065420.4 ENSMUST00000065420.5 ENSMUST00000065420.6 ENSMUST00000065420.7 ENSMUST00000065420.8 ENSMUST00000065420.9 Hjurp NM_172505 uc287kfw.1 uc287kfw.2 nucleus histone binding uc287kfw.1 uc287kfw.2 
ENSMUST00000065422.12 Rpap2 ENSMUST00000065422.12 RNA polymerase II associated protein 2, transcript variant 1 (from RefSeq NM_144911.3) ENSMUST00000065422.1 ENSMUST00000065422.10 ENSMUST00000065422.11 ENSMUST00000065422.2 ENSMUST00000065422.3 ENSMUST00000065422.4 ENSMUST00000065422.5 ENSMUST00000065422.6 ENSMUST00000065422.7 ENSMUST00000065422.8 ENSMUST00000065422.9 NM_144911 Q3TLC8 Q3TSP8 Q3UKX0 Q8C7M5 Q8CBW8 Q8VC34 RPAP2_MOUSE uc008ymp.1 uc008ymp.2 uc008ymp.3 uc008ymp.4 uc008ymp.5 Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:35975910). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD (By similarity). Cytoplasm Nucleus Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8VC34-1; Sequence=Displayed; Name=2; IsoId=Q8VC34-2; Sequence=VSP_020686, VSP_020687; Name=3; IsoId=Q8VC34-3; Sequence=VSP_020685; Name=4; IsoId=Q8VC34-4; Sequence=VSP_020682, VSP_020685; Name=5; IsoId=Q8VC34-5; Sequence=VSP_020683, VSP_020684; Belongs to the RPAP2 family. phosphoprotein phosphatase activity protein serine/threonine phosphatase activity nucleus nucleolus cytoplasm cytosol CTD phosphatase activity snRNA transcription DNA-directed RNA polymerase II, holoenzyme hydrolase activity RNA polymerase core enzyme binding metal ion binding dephosphorylation of RNA polymerase II C-terminal domain uc008ymp.1 uc008ymp.2 uc008ymp.3 uc008ymp.4 uc008ymp.5 
ENSMUST00000065425.12 Spag16 ENSMUST00000065425.12 sperm associated antigen 16, transcript variant 1 (from RefSeq NM_029160.3) ENSMUST00000065425.1 ENSMUST00000065425.10 ENSMUST00000065425.11 ENSMUST00000065425.2 ENSMUST00000065425.3 ENSMUST00000065425.4 ENSMUST00000065425.5 ENSMUST00000065425.6 ENSMUST00000065425.7 ENSMUST00000065425.8 ENSMUST00000065425.9 NM_029160 Pf20 Q0VBE7 Q8C450 Q8K450 Q9CPU8 Q9D522 SPG16_MOUSE uc007bjh.1 uc007bjh.2 uc007bjh.3 uc007bjh.4 Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia. Interacts with SPAG6 and STK36. Cytoplasm Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme Cell projection, cilium, flagellum Note=Detected on the sperm flagellum. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=SPAG16L; IsoId=Q8K450-1; Sequence=Displayed; Name=2; IsoId=Q8K450-2; Sequence=VSP_013507, VSP_013506; Name=3; IsoId=Q8K450-3; Sequence=VSP_013504, VSP_013505; Name=4; Synonyms=SPAG16S; IsoId=Q8K450-4; Sequence=VSP_013503; Expressed in testis. Phosphorylated by TSSK2. protein binding nucleus cytoplasm cytoskeleton cilium axoneme sperm axoneme assembly protein kinase binding cell projection organization motile cilium axoneme assembly sperm flagellum cell projection microtubule sliding cilium assembly cilium movement involved in cell motility cell motility in response to calcium ion axonemal central apparatus uc007bjh.1 uc007bjh.2 uc007bjh.3 uc007bjh.4 
ENSMUST00000065438.13 Cdh22 ENSMUST00000065438.13 cadherin 22 (from RefSeq NM_174988.3) CAD22_MOUSE ENSMUST00000065438.1 ENSMUST00000065438.10 ENSMUST00000065438.11 ENSMUST00000065438.12 ENSMUST00000065438.2 ENSMUST00000065438.3 ENSMUST00000065438.4 ENSMUST00000065438.5 ENSMUST00000065438.6 ENSMUST00000065438.7 ENSMUST00000065438.8 ENSMUST00000065438.9 I7HIP9 NM_174988 Q9WTP5 uc008nxc.1 uc008nxc.2 uc008nxc.3 uc008nxc.4 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues. Cell membrane; Single-pass type I membrane protein. Predominantly expressed in brain. Abundant in olfactory bulb, cerebrum, and cerebellum, less in pons, medulla, and spinal cord. Low expression in heart. No expression in lung, liver, spleen, kidney, testis, stomach, intestine, colon, and placenta. Expressed at 9.5 dpc onwards. At 10.5 dpc, in brain (telencephalic vesicles and isthmus), spinal cord and limb buds (in the zone of polarizing activity). At 14.5 dpc, in olfactory bulb and cerebellum. Down-regulated by thyroid hormone. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules brain development membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules metal ion binding cell-cell adhesion uc008nxc.1 uc008nxc.2 uc008nxc.3 uc008nxc.4 
ENSMUST00000065441.7 Gpr21 ENSMUST00000065441.7 G protein-coupled receptor 21 (from RefSeq NM_177383.4) ENSMUST00000065441.1 ENSMUST00000065441.2 ENSMUST00000065441.3 ENSMUST00000065441.4 ENSMUST00000065441.5 ENSMUST00000065441.6 GPR21_MOUSE NM_177383 Q80T46 Q8BX79 uc008jna.1 uc008jna.2 uc008jna.3 Orphan receptor. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane positive regulation of multicellular organism growth glucose homeostasis negative regulation of insulin receptor signaling pathway uc008jna.1 uc008jna.2 uc008jna.3 
ENSMUST00000065461.9 Usp2 ENSMUST00000065461.9 ubiquitin specific peptidase 2, transcript variant 2 (from RefSeq NM_198091.2) ENSMUST00000065461.1 ENSMUST00000065461.2 ENSMUST00000065461.3 ENSMUST00000065461.4 ENSMUST00000065461.5 ENSMUST00000065461.6 ENSMUST00000065461.7 ENSMUST00000065461.8 MNCb-0190 NM_198091 O88623 Q6X4T9 Q6X4U1 Q8VD74 Q9JJ87 UBP2_MOUSE Ubp41 Usp2 uc009pbp.1 uc009pbp.2 uc009pbp.3 Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (By similarity). Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (By similarity). Has no deubiquitinase activity against p53/TP53 (By similarity). Prevents MDM2-mediated degradation of MDM4 (By similarity). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (By similarity). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (PubMed:23213472, PubMed:25238854, PubMed:26756164). Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (PubMed:23213472). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and BMAL1 (PubMed:25238854). [Isoform 2]: Circadian clock output effector that regulates Ca(2+) absorption in the small intestine. Probably functions by regulating protein levels of the membrane scaffold protein NHERF4 in a rhythmic manner, and is therefore likely to control Ca(2+) membrane permeability mediated by the Ca(2+) channel TRPV6 in the intestine. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Cleavage is inhibited by ubiquitin in a dosage- dependent manner. Cleavage is blocked by ubiquitin aldehyde. Found in trimeric complex with MDM2 and MDM4 and USP2. Interacts with CCND1; the interaction is direct and promotes its stabilization by antagonizing ubiquitin-dependent degradation. Interacts (via N-terminus and C-terminus) with MDM2. Interacts with MDM4 and PER1 (By similarity). Homooligomer. Interacts with KCNQ1; counteracts the NEDD4L-specific down-regulation of I(Ks) and restores plasma membrane localization of KCNQ1 (By similarity). Isoform 2: Interacts with NHERF4 and CLTC (PubMed:26756164). Cytoplasm Cytoplasm, perinuclear region Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. [Isoform 2]: Nucleus Membrane ; Peripheral membrane protein Cytoplasm Note=Predominantly expressed at membranes. Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=O88623-3; Sequence=Displayed; Name=2; Synonyms=Usp2-45 ; IsoId=O88623-2; Sequence=VSP_061746, VSP_061747; Name=4; IsoId=O88623-4; Sequence=VSP_061745, VSP_061748; Isoform 1: Expressed in heart, liver, kidney, pancreas and to a lower extent in skeletal muscle, brain and testis (at protein level) (PubMed:14686789). Expressed in testis, brain, heart and skeletal muscle (PubMed:14686789, PubMed:26756164). Not detected in the small intestine (PubMed:26756164). Isoform 2: Expressed in the small intestine (PubMed:26756164). No stage-dependent developmental pattern of expression is detected. First detected throughout 7.5 dpc embryos. [Isoform 2]: Expressed in a circadian manner in the intestine. The different N-terminus extensions of isoform 1 and isoform 2 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity. Belongs to the peptidase C19 family. USP2 subfamily. negative regulation of transcription from RNA polymerase II promoter thiol-dependent ubiquitin-specific protease activity protein binding nucleus cytoplasm centrosome cell cortex proteolysis ubiquitin-dependent protein catabolic process cell cycle muscle organ development peptidase activity cysteine-type peptidase activity membrane protein deubiquitination hydrolase activity cyclin binding ubiquitin protein ligase binding circadian regulation of gene expression thiol-dependent ubiquitinyl hydrolase activity identical protein binding entrainment of circadian clock by photoperiod locomotor rhythm positive regulation of mitotic cell cycle metal ion binding perinuclear region of cytoplasm rhythmic process circadian behavior negative regulation of skeletal muscle tissue development positive regulation of skeletal muscle tissue development protein stabilization negative regulation of calcium ion transport uc009pbp.1 uc009pbp.2 uc009pbp.3 
ENSMUST00000065465.3 A830005F24Rik ENSMUST00000065465.3 RIKEN cDNA A830005F24 gene (from RefSeq NR_165458.1) ENSMUST00000065465.1 ENSMUST00000065465.2 NR_165458 uc288mqk.1 uc288mqk.2 uc288mqk.3 uc288mqk.1 uc288mqk.2 uc288mqk.3 
ENSMUST00000065486.3 Cib4 ENSMUST00000065486.3 calcium and integrin binding family member 4, transcript variant 1 (from RefSeq NM_028483.2) CIB4_MOUSE ENSMUST00000065486.1 ENSMUST00000065486.2 NM_028483 Q9D9N5 uc008wvo.1 uc008wvo.2 uc008wvo.3 Interacts with ITGA2B (via C-terminus cytoplasmic tail region); the interaction is stabilized/increased in a calcium- and magnesium-dependent manner. Expressed weakly in megakaryocytes and endothelial cells. The binding of either calcium or magnesium may significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form). magnesium ion binding calcium ion binding cellular_component biological_process metal ion binding uc008wvo.1 uc008wvo.2 uc008wvo.3 
ENSMUST00000065515.14 Tfg ENSMUST00000065515.14 Trk-fused gene, transcript variant 1 (from RefSeq NM_019678.3) ENSMUST00000065515.1 ENSMUST00000065515.10 ENSMUST00000065515.11 ENSMUST00000065515.12 ENSMUST00000065515.13 ENSMUST00000065515.2 ENSMUST00000065515.3 ENSMUST00000065515.4 ENSMUST00000065515.5 ENSMUST00000065515.6 ENSMUST00000065515.7 ENSMUST00000065515.8 ENSMUST00000065515.9 NM_019678 Q9Z1A1 Q9Z1A1_MOUSE Tfg uc007zmv.1 uc007zmv.2 uc007zmv.3 uc007zmv.4 Golgi membrane ER to Golgi vesicle-mediated transport identical protein binding COPII vesicle coating endoplasmic reticulum exit site uc007zmv.1 uc007zmv.2 uc007zmv.3 uc007zmv.4 
ENSMUST00000065532.2 Tas2r136 ENSMUST00000065532.2 taste receptor, type 2, member 136 (from RefSeq NM_181276.1) A0A0R4J0W1 A0A0R4J0W1_MOUSE ENSMUST00000065532.1 NM_181276 Tas2r136 uc009ejo.1 uc009ejo.2 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor T2R family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane response to stimulus sensory perception of taste uc009ejo.1 uc009ejo.2 
ENSMUST00000065534.10 Def8 ENSMUST00000065534.10 differentially expressed in FDCP 8, transcript variant 20 (from RefSeq NR_182269.1) D8Ertd713e DEFI8_MOUSE ENSMUST00000065534.1 ENSMUST00000065534.2 ENSMUST00000065534.3 ENSMUST00000065534.4 ENSMUST00000065534.5 ENSMUST00000065534.6 ENSMUST00000065534.7 ENSMUST00000065534.8 ENSMUST00000065534.9 NR_182269 Q3TPT6 Q3UBE6 Q3UZ91 Q8BJN0 Q8BWP0 Q99J78 uc009nvy.1 uc009nvy.2 uc009nvy.3 uc009nvy.4 Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970). Involved in bone resorption (PubMed:27777970). Interacts (via C-terminus) with PLEKHM1; this interaction is weak but increased in a RAB7A-dependent manner (PubMed:27777970). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99J78-1; Sequence=Displayed; Name=2; IsoId=Q99J78-2; Sequence=VSP_031825; Abundantly expressed in peripheral blood leukocytes. Highly expressed in B-cells. Also present in lymph node and appendix. Down-regulated upon macrophage/granulocyte differentiation. Weakly expressed in bone marrow and spleen. Weakly or not expressed in thymus and fetal liver. Abundantly expressed during embryogenesis. Belongs to the DEF8 family. Sequence=BAC34239.1; Type=Erroneous initiation; Evidence=; Sequence=X96708; Type=Frameshift; Evidence=; protein binding cellular_component lysosome localization intracellular signal transduction positive regulation of bone resorption metal ion binding positive regulation of ruffle assembly uc009nvy.1 uc009nvy.2 uc009nvy.3 uc009nvy.4 
ENSMUST00000065536.9 Fam161b ENSMUST00000065536.9 family with sequence similarity 161, member B, transcript variant 2 (from RefSeq NM_001358283.2) ENSMUST00000065536.1 ENSMUST00000065536.2 ENSMUST00000065536.3 ENSMUST00000065536.4 ENSMUST00000065536.5 ENSMUST00000065536.6 ENSMUST00000065536.7 ENSMUST00000065536.8 F161B_MOUSE NM_001358283 Q8BQX8 Q8BSL9 Q8CB59 Q8CBZ3 uc007oez.1 uc007oez.2 uc007oez.3 Interacts with FAM161A. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CB59-1; Sequence=Displayed; Name=2; IsoId=Q8CB59-2; Sequence=VSP_007818, VSP_007819; Belongs to the FAM161 family. molecular_function cytoplasmic microtubule microtubule cytoskeleton cilium organization uc007oez.1 uc007oez.2 uc007oez.3 
ENSMUST00000065537.9 Jmy ENSMUST00000065537.9 junction-mediating and regulatory protein (from RefSeq NM_021310.3) A0A0R4J0V4 A0A0R4J0V4_MOUSE ENSMUST00000065537.1 ENSMUST00000065537.2 ENSMUST00000065537.3 ENSMUST00000065537.4 ENSMUST00000065537.5 ENSMUST00000065537.6 ENSMUST00000065537.7 ENSMUST00000065537.8 Jmy NM_021310 uc007rlf.1 uc007rlf.2 uc007rlf.3 uc007rlf.4 Membrane transcription coactivator activity actin binding regulation of transcription from RNA polymerase II promoter cell leading edge Arp2/3 complex-mediated actin nucleation 'de novo' actin filament nucleation positive regulation of nucleic acid-templated transcription uc007rlf.1 uc007rlf.2 uc007rlf.3 uc007rlf.4 
ENSMUST00000065539.6 Dand5 ENSMUST00000065539.6 DAN domain family member 5, BMP antagonist, transcript variant 1 (from RefSeq NM_201227.3) Cerl2 DAND5_MOUSE ENSMUST00000065539.1 ENSMUST00000065539.2 ENSMUST00000065539.3 ENSMUST00000065539.4 ENSMUST00000065539.5 NM_201227 Q76LW6 Sp1 uc009mnh.1 uc009mnh.2 uc009mnh.3 Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Secreted At 7.0 dpc (early head-fold stage) expressed in perinodal region. At 7.5 dpc (late head-fold stage) expression begins to decrease in intensity on the left side and starts to be asymmetrically up-regulated on the right side of the node. By early 8.0 dpc (somitogenesis), highly expressed in the right side of the node. No expression seen in later stages of development. Mice display multiple laterality defects including randomization of the L/R axis, left pulmonary isomerism thoracic situs inversus and cardiovascular malformations. Belongs to the DAN family. determination of left/right asymmetry in lateral mesoderm ventricular septum development atrial septum development protein binding extracellular region extracellular space determination of left/right symmetry morphogen activity regulation of transforming growth factor beta receptor signaling pathway signal transduction involved in regulation of gene expression negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway sequestering of BMP in extracellular matrix sequestering of nodal from receptor via nodal binding determination of heart left/right asymmetry negative regulation of nodal signaling pathway negative regulation of nodal signaling pathway involved in determination of left/right asymmetry nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry uc009mnh.1 uc009mnh.2 uc009mnh.3 
ENSMUST00000065562.6 Socs4 ENSMUST00000065562.6 suppressor of cytokine signaling 4 (from RefSeq NM_080843.3) ENSMUST00000065562.1 ENSMUST00000065562.2 ENSMUST00000065562.3 ENSMUST00000065562.4 ENSMUST00000065562.5 NM_080843 Q149F7 Q149F8 Q91ZA6 SOCS4_MOUSE Socs7 uc007thx.1 uc007thx.2 uc007thx.3 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity). Protein modification; protein ubiquitination. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. cytosol phosphatidylinositol 3-kinase complex negative regulation of epidermal growth factor-activated receptor activity negative regulation of signal transduction protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process intracellular signal transduction regulation of growth regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity uc007thx.1 uc007thx.2 uc007thx.3 
ENSMUST00000065573.14 Gpatch2 ENSMUST00000065573.14 G patch domain containing 2, transcript variant 1 (from RefSeq NM_026367.4) ENSMUST00000065573.1 ENSMUST00000065573.10 ENSMUST00000065573.11 ENSMUST00000065573.12 ENSMUST00000065573.13 ENSMUST00000065573.2 ENSMUST00000065573.3 ENSMUST00000065573.4 ENSMUST00000065573.5 ENSMUST00000065573.6 ENSMUST00000065573.7 ENSMUST00000065573.8 ENSMUST00000065573.9 GPTC2_MOUSE Gpatc2 NM_026367 Q7TQC7 Q8BNJ9 Q8BPM1 Q8CDH9 uc007dzy.1 uc007dzy.2 uc007dzy.3 uc007dzy.4 uc007dzy.5 Enhances the ATPase activity of DHX15 in vitro. Interacts with DHX15. Nucleus speckle Nucleus, nucleolus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7TQC7-1; Sequence=Displayed; Name=2; IsoId=Q7TQC7-2; Sequence=VSP_010529; Name=3; IsoId=Q7TQC7-3; Sequence=VSP_010530; molecular_function nucleic acid binding nucleus nucleolus negative regulation of phosphatase activity nuclear speck uc007dzy.1 uc007dzy.2 uc007dzy.3 uc007dzy.4 uc007dzy.5 
ENSMUST00000065587.5 Ackr3 ENSMUST00000065587.5 atypical chemokine receptor 3, transcript variant 2 (from RefSeq NM_007722.4) ACKR3_MOUSE Ackr3 Cmkor1 Cxcr7 ENSMUST00000065587.1 ENSMUST00000065587.2 ENSMUST00000065587.3 ENSMUST00000065587.4 NM_007722 P56485 Q91WI0 Rdc1 uc007bzh.1 uc007bzh.2 uc007bzh.3 uc007bzh.4 uc007bzh.5 Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein- mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels (PubMed:31211835). Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2. Cell membrane ; Multi-pass membrane protein Early endosome Recycling endosome Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits in a beta-arrestin-dependent manner. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane. Not detected in blood, liver, lung and heart, but high expression detected in several tumor cell lines (at protein level). Expressed in heart, spleen, kidney, lung, ovary, brain, testis, astrocytes, neutrophils and B-lymphocytes. Expression detected after 9.5 dpc in the endothelial layer of the forming heart, neural tube, brain and septum transversum. At 10.5 dpc, expressed at high levels in the prosencephalon and in a part of the rhombencephalon and at lower levels in the neural tube, somites and heart. Detected in liver at 11 dpc and 13 dpc, but not at 15 dpc and 17 dpc. During heart development, expression detected mainly in endocardial cells and endocardial cushion mesenchymal cells in both outflow tract and atrioventricular canal regions and to a lesser degree in myocardial cells at 10.5 dpc, in the mesenchyme of the forming valves and in numerous microvessels in the myocardium at 12.5 dpc, and from 14.5 dpc onward mainly in the microvasculature associated with myocardium, valves and great vessels. In developing telencephalon, observed at 11.5 dpc in the ventral telencephalon in proliferative zones of the medial ganglionic eminence (MGE), in ventral part of the lateral ganglionic eminence (LGE) and in Cajal-Retzius (CR) neurons of dorsal telencephalon. At 12.5 dpc, detected in migrating olfactory tubercle neuron precursors and cortical interneurons, and in CR cells and subplate neurons of the cortex. At 13.5 dpc, observed in the germinal zone of MGE in the subpallium, in the marginal zone and cortical subventricular zone (SVZ) of the lateral cortex as well as in pyramidal cells and tangentially migrating interneurons. At postnatal stages, expressed in postnatal cortical plate and in migrating olfactory bulb interneurons in the striatal SVZ and rostral migratory stream. Expressed in the developing neuroepithelium in the region of the developing oculomotor nucleus at 11.5 dpc and 13.5 dpc (PubMed:31211835). The C-terminal cytoplasmic tail, plays a key role in: correct trafficking to the cell membrane, recruitment of beta-arrestin, ubiquitination, and in chemokine scavenging and signaling functions. The Ser/Thr residues and the Lys residues in the C-terminal cytoplasmic tail are essential for beta-arrestin recruitment and ubiquitination respectively. The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated. Ubiquitinated at the Lys residues in its C-terminal cytoplasmic tail and is essential for correct trafficking from and to the cell membrane. Deubiquitinated by CXCL12-stimulation in a reversible manner. Lethal at perinatal stages, with most of the neonates dying within 24 hours. Mutants display slightly enlarged heart, but no clear effect on heart functionality is observed. Mutant mice display abnormalities in semilunar valves and ventricles, myocardial degeneration and fibrosis, as well as abnormal intracortical migration of interneurons and premature invasion of the cortical plate. According to PubMed:17804806, mutants display ventricular septal and atrial septal defects. According to PubMed:21246655, mutants display ventricular septal defects but no atrial septal defects. According to PubMed:18442043, no abnormalities in semilunar valve formation or ventricular septal defects are observed. No effect on hematopoiesis, neural development and gastrointestinal vascularization is observed. No apparent bone phenotype is observed. Mutant embryos show oculomotor nerve misrouting, ranging from complete misprojection in the midbrain, to aberrant peripheral branching, to a thin nerve, which aberrantly innervates the lateral rectus (PubMed:31211835). Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily. angiogenesis vasculogenesis G-protein coupled receptor activity scavenger receptor activity nucleus cytoplasm endosome early endosome plasma membrane clathrin-coated pit chemotaxis immune response cell adhesion signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration multicellular organism development external side of plasma membrane cell surface coreceptor activity membrane integral component of membrane C-C chemokine receptor activity C-X-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding C-X-C chemokine binding receptor internalization intracellular membrane-bounded organelle perinuclear region of cytoplasm recycling endosome cell chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of mesenchymal stem cell migration uc007bzh.1 uc007bzh.2 uc007bzh.3 uc007bzh.4 uc007bzh.5 
ENSMUST00000065588.7 Gbp10 ENSMUST00000065588.7 guanylate-binding protein 10 (from RefSeq NM_001039646.2) D3YWK4 ENSMUST00000065588.1 ENSMUST00000065588.2 ENSMUST00000065588.3 ENSMUST00000065588.4 ENSMUST00000065588.5 ENSMUST00000065588.6 Gbp10 NM_001039646 Q000W5 Q000W5_MOUSE uc008ykz.1 uc008ykz.2 uc008ykz.3 Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. nucleotide binding GTPase activity GTP binding symbiont-containing vacuole membrane cytoplasmic vesicle defense response to protozoan defense response to Gram-positive bacterium cellular response to lipopolysaccharide cellular response to interferon-gamma uc008ykz.1 uc008ykz.2 uc008ykz.3 
ENSMUST00000065600.8 Kics2 ENSMUST00000065600.8 KICSTOR subunit 2, transcript variant 1 (from RefSeq NM_173022.3) ENSMUST00000065600.1 ENSMUST00000065600.2 ENSMUST00000065600.3 ENSMUST00000065600.4 ENSMUST00000065600.5 ENSMUST00000065600.6 ENSMUST00000065600.7 KICS2_MOUSE Kics2 NM_173022 Q3TE08 Q3TRB8 Q6P1I3 Q8C334 uc007hfx.1 uc007hfx.2 uc007hfx.3 As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. Part of the KICSTOR complex composed of KPTN, ITFG2, KICS2 and SZT2. SZT2 probably serves as a link between the other three proteins in the KICSTOR complex and may mediate the direct interaction with the GATOR complex via GATOR1. The KICSTOR complex interacts directly with the GATOR1 complex and most probably indirectly with the GATOR2 complex in an amino acid-independent manner. Lysosome membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P1I3-1; Sequence=Displayed; Name=2; IsoId=Q6P1I3-2; Sequence=VSP_031819, VSP_031820; Belongs to the KICS2 family. Sequence=BAC39804.1; Type=Frameshift; Evidence=; Sequence=BAE41440.1; Type=Frameshift; Evidence=; molecular_function lysosome lysosomal membrane membrane cellular response to amino acid starvation cellular response to glucose starvation protein localization to lysosome negative regulation of TORC1 signaling uc007hfx.1 uc007hfx.2 uc007hfx.3 
ENSMUST00000065601.13 Btrc ENSMUST00000065601.13 beta-transducin repeat containing protein, transcript variant 10 (from RefSeq NM_001409992.1) Btrc ENSMUST00000065601.1 ENSMUST00000065601.10 ENSMUST00000065601.11 ENSMUST00000065601.12 ENSMUST00000065601.2 ENSMUST00000065601.3 ENSMUST00000065601.4 ENSMUST00000065601.5 ENSMUST00000065601.6 ENSMUST00000065601.7 ENSMUST00000065601.8 ENSMUST00000065601.9 FBW1A_MOUSE Fbw1 Fbxw1 Fwd1 Kiaa4123 NM_001409992 Q3U0Q4 Q3ULA2 Q571K6 Q9QUI5 Q9R1G7 Q9Z159 uc008hqy.1 uc008hqy.2 uc008hqy.3 uc008hqy.4 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10097128, PubMed:16371461, PubMed:18782782, PubMed:9859996, PubMed:9990853, PubMed:21911472, PubMed:29593216). Recognizes and binds to phosphorylated target proteins (PubMed:10097128, PubMed:16371461, PubMed:18782782, PubMed:9859996, PubMed:9990853, PubMed:21911472). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (By similarity). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:9859996, PubMed:10097128). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:9859996, PubMed:10097128). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (By similarity). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (PubMed:21911472). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:18782782). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1- CUL4 E3 ubiquitin-protein ligase (By similarity). Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF (By similarity). Required for proteolytic processing of GLI3 (PubMed:16371461). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (By similarity). SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (By similarity). Protein modification; protein ubiquitination. Homodimer. Self-associates. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. Direct interaction with SKP1 with SKP1 occurs via the F-box domain. Interacts with phosphorylated ubiquitination substrates SMAD3 and SMAD4. Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, NFKBIB, NFKBIE, NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5 and SNAI1; the interaction requires the phosphorylation of the 2 serine residues in the substrate destruction motif D-S-G- X(2,3,4)-S. Binds UBQLN1. Interacts with CDC34 and UBE2R2. Interacts with FBXW11. Interacts with CUL4A and DDB1. Part of a SCF(BTRC)-like complex lacking CUL1, which is associated with phosphorylated NKBIA and RELA; RELA interacts directly with NFKBIA. Interacts with the phosphorylated form of GLI3. Interacts with CLU. Interacts with PER1 (phosphorylated), PER2 (phosphorylated) and PER3. Interacts with phosphorylated ubiquitination substrate CEP68 (By similarity). Interacts with ZC3H12A; this interaction occurs when ZC3H12A is phosphorylated in a IKBKB/IKKB-dependent manner (PubMed:22037600). Interacts with HSF1; this interaction occurs during mitosis and induces HSF1 ubiquitin-dependent degradation, a process inhibited by CDC20 (By similarity). Interacts with NFE2L1 (PubMed:21911472). Interacts with INAVA (By similarity). Interacts with IL10RA; this interaction leads to IL10RA ubiquitination and subsequent degradation (By similarity). Interacts with REST (By similarity). Interacts with KLF4; this interaction leads to KLF4 ubiquitination and subsequent degradation (PubMed:29593216). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q3ULA2-1; Sequence=Displayed; Name=2 IsoId=Q3ULA2-2; Sequence=VSP_053208; Expressed in heart, brain, liver, skeletal muscle and, most strongly, in testis. The N-terminal D domain mediates homodimerization. Ubiquitinated. Deubiquitinated by OTUD5, promoting its stability. Mutants have normal circadian behavior with normal PER2 expression in the suprachiasmatic nucleus. PubMed:10531037 wrongly lists the species as human. Sequence=BAD90368.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein polyubiquitination ubiquitin-protein transferase activity protein binding nucleus cytoplasm cytosol protein dephosphorylation ubiquitin-dependent protein catabolic process beta-catenin binding Wnt signaling pathway protein ubiquitination SCF ubiquitin ligase complex protein catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein destabilization mammary gland epithelial cell proliferation regulation of circadian rhythm positive regulation of circadian rhythm regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process protein phosphorylated amino acid binding positive regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated protein dimerization activity rhythmic process regulation of cell cycle branching involved in mammary gland duct morphogenesis regulation of canonical Wnt signaling pathway regulation of proteasomal protein catabolic process ubiquitin protein ligase activity cellular response to organic cyclic compound uc008hqy.1 uc008hqy.2 uc008hqy.3 uc008hqy.4 
ENSMUST00000065603.12 Lrrc49 ENSMUST00000065603.12 leucine rich repeat containing 49, transcript variant 2 (from RefSeq NM_145616.4) E9QM16 E9QM16_MOUSE ENSMUST00000065603.1 ENSMUST00000065603.10 ENSMUST00000065603.11 ENSMUST00000065603.2 ENSMUST00000065603.3 ENSMUST00000065603.4 ENSMUST00000065603.5 ENSMUST00000065603.6 ENSMUST00000065603.7 ENSMUST00000065603.8 ENSMUST00000065603.9 Lrrc49 NM_145616 uc009pze.1 uc009pze.2 uc009pze.3 uc009pze.4 uc009pze.5 uc009pze.6 uc009pze.1 uc009pze.2 uc009pze.3 uc009pze.4 uc009pze.5 uc009pze.6 
ENSMUST00000065625.12 Trmt1l ENSMUST00000065625.12 tRNA methyltransferase 1 like, transcript variant 1 (from RefSeq NM_026876.4) A0A0R4J0U8 A0A0R4J0U8_MOUSE ENSMUST00000065625.1 ENSMUST00000065625.10 ENSMUST00000065625.11 ENSMUST00000065625.2 ENSMUST00000065625.3 ENSMUST00000065625.4 ENSMUST00000065625.5 ENSMUST00000065625.6 ENSMUST00000065625.7 ENSMUST00000065625.8 ENSMUST00000065625.9 NM_026876 Trmt1l uc007cyv.1 uc007cyv.2 uc007cyv.3 uc007cyv.4 May play a role in motor coordination and exploratory behavior. tRNA binding nucleic acid binding RNA binding tRNA (guanine-N2-)-methyltransferase activity tRNA processing methyltransferase activity transferase activity tRNA methylation methylation uc007cyv.1 uc007cyv.2 uc007cyv.3 uc007cyv.4 
ENSMUST00000065630.8 Ddx10 ENSMUST00000065630.8 DEAD box helicase 10 (from RefSeq NM_029936.2) DDX10_MOUSE ENSMUST00000065630.1 ENSMUST00000065630.2 ENSMUST00000065630.3 ENSMUST00000065630.4 ENSMUST00000065630.5 ENSMUST00000065630.6 ENSMUST00000065630.7 NM_029936 Q80Y44 uc009plz.1 uc009plz.2 uc009plz.3 uc009plz.4 Putative ATP-dependent RNA helicase. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily. Sequence=AAH49261.1; Type=Erroneous initiation; Evidence=; nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus rRNA processing hydrolase activity anterior head development uc009plz.1 uc009plz.2 uc009plz.3 uc009plz.4 
ENSMUST00000065634.8 Slc22a26 ENSMUST00000065634.8 solute carrier family 22 (organic cation transporter), member 26 (from RefSeq NM_146232.1) BC014805 ENSMUST00000065634.1 ENSMUST00000065634.2 ENSMUST00000065634.3 ENSMUST00000065634.4 ENSMUST00000065634.5 ENSMUST00000065634.6 ENSMUST00000065634.7 NM_146232 Q91WJ2 Q91WJ2_MOUSE Slc22a26 uc008glr.1 uc008glr.2 uc008glr.3 uc008glr.4 Membrane ; Multi- pass membrane protein organic anion transport membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008glr.1 uc008glr.2 uc008glr.3 uc008glr.4 
ENSMUST00000065651.5 Slc22a28 ENSMUST00000065651.5 solute carrier family 22, member 28 (from RefSeq NM_001013820.3) B2RT89 B2RT89_MOUSE EG434674 ENSMUST00000065651.1 ENSMUST00000065651.2 ENSMUST00000065651.3 ENSMUST00000065651.4 Gm5631 NM_001013820 Slc22a28 uc008glt.1 uc008glt.2 Membrane ; Multi- pass membrane protein organic anion transport membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008glt.1 uc008glt.2 
ENSMUST00000065666.6 Retnlg ENSMUST00000065666.6 resistin like gamma (from RefSeq NM_181596.4) ENSMUST00000065666.1 ENSMUST00000065666.2 ENSMUST00000065666.3 ENSMUST00000065666.4 ENSMUST00000065666.5 NM_181596 Q7TM98 Q8K426 RETNG_MOUSE Retnlg Xcp1 uc007zjw.1 uc007zjw.2 uc007zjw.3 uc007zjw.4 Probable hormone (Probable). Promotes chemotaxis in myeloid cells (PubMed:15064728). Homodimer. Heterodimer with RETNLB. Secreted Expressed in colon, lung, spleen, pancreas, ileum and bone marrow (at protein level) (PubMed:15834545). In colon, found throughout the crypt and surface epithelium, including goblet cells (at protein level) (PubMed:15834545). Highest expression is observed in bone marrow, spleen and lung, with lower levels in other tissues (PubMed:12782128, PubMed:14733912, PubMed:15064728, PubMed:15834545). Detected at low levels in granulocytes, but not found in monocytes or lymphocytes (PubMed:14733912). Has very weak expression in white adipose tissue (PubMed:12782128). In liver, strongly expressed at 18 dpc and at birth, and then rapidly declines. In pancreas, strongly expressed at birth with decreasing expression after 4 days of age. Also shows strong expression in neonatal gut, lung and heart. Up-regulated in colon and bone marrow in response to a high- fat diet. Also up-regulated in obese mice mutant for the leptin receptor LEPR (db/db genotype). Belongs to the resistin/FIZZ family. Sequence=AAI17107.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC78641.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAD56117.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; myeloid dendritic cell chemotaxis hormone activity extracellular region extracellular space signal transduction uc007zjw.1 uc007zjw.2 uc007zjw.3 uc007zjw.4 
ENSMUST00000065668.12 Nrgn ENSMUST00000065668.12 neurogranin (from RefSeq NM_022029.2) B2RRN7 ENSMUST00000065668.1 ENSMUST00000065668.10 ENSMUST00000065668.11 ENSMUST00000065668.2 ENSMUST00000065668.3 ENSMUST00000065668.4 ENSMUST00000065668.5 ENSMUST00000065668.6 ENSMUST00000065668.7 ENSMUST00000065668.8 ENSMUST00000065668.9 NEUG_MOUSE NM_022029 P60761 Q3TYH4 uc009ovc.1 uc009ovc.2 uc009ovc.3 Regulates the affinity of calmodulin for calcium. Involved in synaptic plasticity and spatial learning. Interacts with apo-calmodulin; this interaction decreases the affinity of calmodulin for calcium ions. Cytoplasm. Synapse. Cell projection, dendritic spine. Note=Restricted to dendritic spines of a subset of neurons. Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation. Disulfide bond formation is redox-sensitive. The cysteine residues are readily oxidized by several nitric acid (NO) donors and other oxidants to form intramolecular disulfide. Cys-51 can form a disulfide with any other of the cysteine residues with an order of reactivity Cys-9 > Cys-4 > Cys-3 (By similarity). Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions. Belongs to the neurogranin family. calmodulin binding phosphatidylinositol-3,4,5-trisphosphate binding nucleus cytoplasm associative learning trans-Golgi network transport vesicle membrane postsynaptic density telencephalon development cell junction axon dendrite mitochondrial membrane intracellular signal transduction cell projection neuronal cell body dendritic spine dendritic spine head synapse postsynaptic membrane phosphatidic acid binding postsynapse glutamatergic synapse positive regulation of long-term synaptic potentiation uc009ovc.1 uc009ovc.2 uc009ovc.3 
ENSMUST00000065678.6 Sec61b ENSMUST00000065678.6 SEC61 translocon subunit beta (from RefSeq NM_024171.2) ENSMUST00000065678.1 ENSMUST00000065678.2 ENSMUST00000065678.3 ENSMUST00000065678.4 ENSMUST00000065678.5 NM_024171 Q9CQS8 SC61B_MOUSE Sec61b uc008sur.1 uc008sur.2 uc008sur.3 Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (By similarity). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). Required for PKD1/Polycystin-1 biogenesis (PubMed:28375157). The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (By similarity). The SEC61 channel associates with the multi-pass translocon (MPT) complex. Interacts with TRAM1 (By similarity). Endoplasmic reticulum membrane ; Single-pass membrane protein Belongs to the SEC61-beta family. ARF guanyl-nucleotide exchange factor activity protein binding endoplasmic reticulum Sec61 translocon complex endoplasmic reticulum membrane SRP-dependent cotranslational protein targeting to membrane, translocation intracellular protein transport protein transport membrane integral component of membrane ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol posttranslational protein targeting to membrane, translocation endoplasmic reticulum Sec complex ribosome binding endoplasmic reticulum quality control compartment epidermal growth factor binding P-P-bond-hydrolysis-driven protein transmembrane transporter activity uc008sur.1 uc008sur.2 uc008sur.3 
ENSMUST00000065679.8 Slamf8 ENSMUST00000065679.8 SLAM family member 8 (from RefSeq NM_029084.3) ENSMUST00000065679.1 ENSMUST00000065679.2 ENSMUST00000065679.3 ENSMUST00000065679.4 ENSMUST00000065679.5 ENSMUST00000065679.6 ENSMUST00000065679.7 NM_029084 Q3UQA2 Q3UQA2_MOUSE Slamf8 uc007dqu.1 uc007dqu.2 uc007dqu.3 membrane integral component of membrane uc007dqu.1 uc007dqu.2 uc007dqu.3 
ENSMUST00000065694.8 Dis3l2 ENSMUST00000065694.8 DIS3 like 3'-5' exoribonuclease 2, transcript variant 2 (from RefSeq NM_153530.2) DI3L2_MOUSE ENSMUST00000065694.1 ENSMUST00000065694.2 ENSMUST00000065694.3 ENSMUST00000065694.4 ENSMUST00000065694.5 ENSMUST00000065694.6 ENSMUST00000065694.7 NM_153530 Q8BMG9 Q8CI75 uc007bvv.1 uc007bvv.2 uc007bvv.3 uc007bvv.4 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= Interacts with XRN1. Q8CI75; Q8K3Y3: Lin28a; NbExp=2; IntAct=EBI-16045218, EBI-11109197; Cytoplasm toplasm, P-body Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CI75-1; Sequence=Displayed; Name=2; IsoId=Q8CI75-2; Sequence=VSP_030379; Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. Sequence=BAC27292.1; Type=Frameshift; Evidence=; 3'-5'-exoribonuclease activity exosome (RNase complex) mitotic cell cycle magnesium ion binding nuclear-transcribed mRNA catabolic process, exonucleolytic P-body RNA binding nuclease activity exonuclease activity ribonuclease activity protein binding cytoplasm cell cycle poly(U) RNA binding negative regulation of cell proliferation miRNA catabolic process hydrolase activity stem cell population maintenance nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' metal ion binding cell division mitotic sister chromatid separation nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic polyuridylation-dependent mRNA catabolic process uc007bvv.1 uc007bvv.2 uc007bvv.3 uc007bvv.4 
ENSMUST00000065698.7 Ficd ENSMUST00000065698.7 FIC domain containing (from RefSeq NM_001010825.3) A4QPF9 D5Ertd40e ENSMUST00000065698.1 ENSMUST00000065698.2 ENSMUST00000065698.3 ENSMUST00000065698.4 ENSMUST00000065698.5 ENSMUST00000065698.6 FICD_MOUSE Ficd NM_001010825 Q8BIC9 Q8BIX9 Q8BJ12 uc008yyl.1 uc008yyl.2 uc008yyl.3 uc008yyl.4 Protein that can both mediate the addition of adenosine 5'- monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (By similarity). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (By similarity). Reaction=ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L- tyrosyl-[protein]; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108; Evidence=; Reaction=3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = AMP + H(+) + L- threonyl-[protein]; Xref=Rhea:RHEA:55932, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13847, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:138113, ChEBI:CHEBI:456215; Evidence=; Reaction=ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl- [protein] + diphosphate; Xref=Rhea:RHEA:54292, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13847, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:138113; EC=2.7.7.108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Divalent metal cation. Prefers Mn(2+) over Mg(2+). ; The side chain of Glu-234 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. In response to endoplasmic reticulum stress, mediates de-AMPylase activity (By similarity). Adenylyltransferase activity is inhibited by the inhibitory helix present at the N-terminus: Glu-234 binds ATP and competes with ATP-binding at Arg-374, thereby preventing adenylyltransferase activity (By similarity). In unstressed cells, disengagement of Glu-234 promotes adenylyltransferase activity (By similarity). Activation dissociates ATP-binding from Glu-234, allowing ordered binding of the entire ATP moiety with the alpha-phosphate in an orientation that is productive for accepting an incoming target hydroxyl side chain (By similarity). Homodimer. Interacts with HD. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BIX9-1; Sequence=Displayed; Name=2; IsoId=Q8BIX9-2; Sequence=VSP_030934; The fido domain mediates the adenylyltransferase activity. Auto-AMPylated in vitro. Belongs to the fic family. nucleotide binding ATP binding endoplasmic reticulum endoplasmic reticulum membrane response to unfolded protein membrane integral component of membrane transferase activity nucleotidyltransferase activity hydrolase activity protein adenylylation integral component of endoplasmic reticulum membrane Hsp70 protein binding response to endoplasmic reticulum stress identical protein binding protein homodimerization activity protein deadenylylation protein adenylylhydrolase activity chaperone binding protein adenylyltransferase activity regulation of IRE1-mediated unfolded protein response uc008yyl.1 uc008yyl.2 uc008yyl.3 uc008yyl.4 
ENSMUST00000065731.6 2310001K24Rik ENSMUST00000065731.6 2310001K24Rik (from geneSymbol) ENSMUST00000065731.1 ENSMUST00000065731.2 ENSMUST00000065731.3 ENSMUST00000065731.4 ENSMUST00000065731.5 uc012cir.1 uc012cir.2 uc012cir.3 uc012cir.1 uc012cir.2 uc012cir.3 
ENSMUST00000065740.3 Gm9905 ENSMUST00000065740.3 Gm9905 (from geneSymbol) ENSMUST00000065740.1 ENSMUST00000065740.2 uc057cay.1 uc057cay.2 uc057cay.3 uc057cay.1 uc057cay.2 uc057cay.3 
ENSMUST00000065745.10 Rxfp2 ENSMUST00000065745.10 relaxin/insulin-like family peptide receptor 2, transcript variant 1 (from RefSeq NM_080468.2) ENSMUST00000065745.1 ENSMUST00000065745.2 ENSMUST00000065745.3 ENSMUST00000065745.4 ENSMUST00000065745.5 ENSMUST00000065745.6 ENSMUST00000065745.7 ENSMUST00000065745.8 ENSMUST00000065745.9 Gpr106 Great Lgr8 NM_080468 Q0VB90 Q91ZZ5 RXFP2_MOUSE uc009atp.1 uc009atp.2 uc009atp.3 uc009atp.4 Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity). Cell membrane; Multi-pass membrane protein. Expressed in embryonic and adult gonads of males and females, as well in male gubernarculum. Expressed also in brain. Not detected in kidney, spleen and heart. Note=Defects in Rxfp2 seems to be a cause of impaired testicular descent (known as cryptorchidism). Belongs to the G-protein coupled receptor 1 family. By homology with the human sequence, it is uncertain whether Met-1 is the initiator. oocyte maturation G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway negative regulation of cell proliferation G-protein coupled peptide receptor activity male gonad development hormone-mediated signaling pathway membrane integral component of membrane protein-hormone receptor activity peptide hormone binding negative regulation of apoptotic process positive regulation of cAMP-mediated signaling uc009atp.1 uc009atp.2 uc009atp.3 uc009atp.4 
ENSMUST00000065766.7 Adamts6 ENSMUST00000065766.7 ADAM metallopeptidase with thrombospondin type 1 motif 6, transcript variant 1 (from RefSeq NM_001081020.2) Adamts6 D3Z1A5 D3Z1A5_MOUSE ENSMUST00000065766.1 ENSMUST00000065766.2 ENSMUST00000065766.3 ENSMUST00000065766.4 ENSMUST00000065766.5 ENSMUST00000065766.6 NM_001081020 uc007rti.1 uc007rti.2 uc007rti.3 uc007rti.4 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix Lacks conserved residue(s) required for the propagation of feature annotation. cardiac septum development molecular_function metalloendopeptidase activity cellular_component proteolysis heart development peptidase activity metallopeptidase activity aorta development coronary vasculature development uc007rti.1 uc007rti.2 uc007rti.3 uc007rti.4 
ENSMUST00000065767.9 Poglut2 ENSMUST00000065767.9 protein O-glucosyltransferase 2 (from RefSeq NM_023645.3) ENSMUST00000065767.1 ENSMUST00000065767.2 ENSMUST00000065767.3 ENSMUST00000065767.4 ENSMUST00000065767.5 ENSMUST00000065767.6 ENSMUST00000065767.7 ENSMUST00000065767.8 Ep58 Kdelc1 NM_023645 PLGT2_MOUSE Q8BPU6 Q8C528 Q8R591 Q9D8P1 Q9JHP7 uc007awb.1 uc007awb.2 uc007awb.3 Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway. Reaction=L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O- (beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:58116, Rhea:RHEA-COMP:14610, Rhea:RHEA-COMP:16010, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885, ChEBI:CHEBI:140576; Evidence=; Reaction=L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O- (beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:62016, Rhea:RHEA-COMP:16010, Rhea:RHEA-COMP:16011, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:132085; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum lumen Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9JHP7-1; Sequence=Displayed; Name=2; IsoId=Q9JHP7-2; Sequence=VSP_019936; Name=3; IsoId=Q9JHP7-3; Sequence=VSP_019935; Widely expressed. Expressed in various fetal tissues. N-glycosylated. Belongs to the KDELC family. endoplasmic reticulum endoplasmic reticulum lumen protein glycosylation transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via serine protein xylosyltransferase activity UDP-glucosyltransferase activity UDP-xylosyltransferase activity glucosyltransferase activity uc007awb.1 uc007awb.2 uc007awb.3 
ENSMUST00000065781.5 Tas2r107 ENSMUST00000065781.5 taste receptor, type 2, member 107 (from RefSeq NM_199154.2) ENSMUST00000065781.1 ENSMUST00000065781.2 ENSMUST00000065781.3 ENSMUST00000065781.4 NM_199154 Q71QD3 Q7M725 T2r4 T2r43 TR107_MOUSE Tas2r107 uc009eiw.1 uc009eiw.2 uc009eiw.3 Putative taste receptor which may play a role in the perception of bitterness. Membrane ; Multi-pass membrane protein Several bitter taste receptors with distinct ligand specificities are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane response to stimulus sensory perception of taste uc009eiw.1 uc009eiw.2 uc009eiw.3 
ENSMUST00000065785.4 Trim50 ENSMUST00000065785.4 tripartite motif-containing 50, transcript variant 1 (from RefSeq NM_178240.3) ENSMUST00000065785.1 ENSMUST00000065785.2 ENSMUST00000065785.3 NM_178240 Q810I2 TRI50_MOUSE uc008zyf.1 uc008zyf.2 uc008zyf.3 E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 (PubMed:29604308). In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction (PubMed:22792322). Promotes also NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (PubMed:36178239). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Can form dimers and trimers. Interacts with several E2 ubiquitin-conjugating enzymes, including UBE2L6, UBE2E1, UBE2E3. No interaction with UBE2H. Interacts with BECN1. Interacts with SQSTM1. Interacts with NLRP3 (PubMed:36178239). Cytoplasm te=Localizes mainly into discrete cytoplasmic punctuate structures heterogeneous in size and shape containing polyubiquitinated proteins. Expressed in the stomach. Auto-ubiquitinated. Acetylated by EP300 and KAT2B. HDAC6 drives TRIM50 deacetylation. Acetylation antagonizes with TRIM50 ubiquitination. TRIM50-deficient mice show a significantly prolonged survival time when LPS-challenged when compared with wild- type mice. TRIM50 deficiency also significantly ameliorates NLRP3- mediated inflammation and tissue damage in vivo. Belongs to the TRIM/RBCC family. protein binding cytoplasm cytosol zinc ion binding aggresome transferase activity identical protein binding metal ion binding regulation of establishment of protein localization uc008zyf.1 uc008zyf.2 uc008zyf.3 
ENSMUST00000065793.12 Phgdh ENSMUST00000065793.12 3-phosphoglycerate dehydrogenase (from RefSeq NM_016966.3) ENSMUST00000065793.1 ENSMUST00000065793.10 ENSMUST00000065793.11 ENSMUST00000065793.2 ENSMUST00000065793.3 ENSMUST00000065793.4 ENSMUST00000065793.5 ENSMUST00000065793.6 ENSMUST00000065793.7 ENSMUST00000065793.8 ENSMUST00000065793.9 NM_016966 Q3TEE5 Q61753 Q75SV9 Q8C603 SERA_MOUSE uc008qps.1 uc008qps.2 uc008qps.3 Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Does not catalyze the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. Reaction=(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH; Xref=Rhea:RHEA:12641, ChEBI:CHEBI:15378, ChEBI:CHEBI:18110, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58272; EC=1.1.1.95; Evidence=; Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3. Homotetramer. Decreased level of free serine, glycine, taurine, GABA, glutamine, and threonine in spinal cord and head. Impaired central nervous system (CNS) with shorter neural tube length and overall growth retardation. Severe atrophy at the thoracic level, particularly in the dorsal spinal cord. Poorly developed dorsal horn and adjacent mantle zone. Neurons fail to develop neurites, particularly commissural axonal fibers. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. phosphoglycerate dehydrogenase activity cellular amino acid metabolic process glutamine metabolic process glycine metabolic process L-serine metabolic process L-serine biosynthetic process threonine metabolic process cellular amino acid biosynthetic process gamma-aminobutyric acid metabolic process regulation of gene expression oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor taurine metabolic process spinal cord development glial cell development neural tube development neurogenesis neuron projection development myelin sheath NAD binding oxidation-reduction process G1 to G0 transition uc008qps.1 uc008qps.2 uc008qps.3 
ENSMUST00000065796.10 Jak2 ENSMUST00000065796.10 Janus kinase 2, transcript variant 1 (from RefSeq NM_008413.4) ENSMUST00000065796.1 ENSMUST00000065796.2 ENSMUST00000065796.3 ENSMUST00000065796.4 ENSMUST00000065796.5 ENSMUST00000065796.6 ENSMUST00000065796.7 ENSMUST00000065796.8 ENSMUST00000065796.9 G5E852 JAK2_MOUSE Jak2 NM_008413 Q62120 Q62124 Q7TQD0 uc008hdb.1 uc008hdb.2 uc008hdb.3 uc008hdb.4 Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Mn(2+) was used in the in vitro kinase assay but Mg(2+) is likely to be the in vivo cofactor. ; Regulated by autophosphorylation, can both activate or decrease activity (PubMed:8343951, PubMed:20304997, PubMed:21726629). Heme regulates its activity by enhancing the phosphorylation on Tyr-1007 and Tyr-1008 (By similarity). Interacts with IL23R, SKB1 and STAM2 (By similarity). Interacts with EPOR (PubMed:8343951, PubMed:11779507). Interacts with LYN (PubMed:9573010). Interacts with SIRPA (PubMed:10842184). Interacts with SH2B1 (PubMed:17565041, PubMed:16824542). Interacts with TEC (PubMed:9473212). Interacts with IFNGR2 (via intracellular domain) (By similarity). Interacts with LEPR (Isoform B) (PubMed:11923481). Interacts with HSP90AB1; promotes functional activation in a heat shock-dependent manner. Interacts with STRA6 (By similarity). Interacts with ASB2; the interaction targets JAK2 for Notch-induced proteasomal degradation (By similarity). Q62120; P14753: Epor; NbExp=4; IntAct=EBI-646604, EBI-617901; Q62120; P20491: Fcer1g; NbExp=2; IntAct=EBI-646604, EBI-9306159; Q62120; P48356: Lepr; NbExp=3; IntAct=EBI-646604, EBI-2257257; Q62120; Q91ZM2: Sh2b1; NbExp=3; IntAct=EBI-646604, EBI-7178606; Q62120; P46527: CDKN1B; Xeno; NbExp=7; IntAct=EBI-646604, EBI-519280; Q62120; Q5VWK5: IL23R; Xeno; NbExp=2; IntAct=EBI-646604, EBI-10248005; Q62120; P10686: Plcg1; Xeno; NbExp=3; IntAct=EBI-646604, EBI-520788; Q62120; P29353: SHC1; Xeno; NbExp=2; IntAct=EBI-646604, EBI-78835; Endomembrane system; Peripheral membrane protein. Cytoplasm Nucleus Ubiquitously expressed throughout most tissues. Possesses 2 protein kinase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for protein kinase 1. Autophosphorylated, leading to regulate its activity. Leptin promotes phosphorylation on tyrosine residues, including phosphorylation on Tyr-813 (PubMed:16824542, PubMed:17565041). Autophosphorylation on Tyr-119 in response to EPO down-regulates its kinase activity (PubMed:17024180). Autophosphorylation on Tyr-868, Tyr- 966 and Tyr-972 in response to growth hormone (GH) are required for maximal kinase activity (PubMed:20304997). Also phosphorylated by TEC (PubMed:9473212). Phosphorylated on tyrosine residues in response to interferon gamma signaling (By similarity). Phosphorylated on tyrosine residues in response to a signaling cascade that is activated by increased cellular retinol (PubMed:21368206). Undergoes Notch-induced ubiquitination and subsequent proteasomal degradation which is mediated by ASB1 or ASB2, the substrate- recognition components of probable ECS E3 ubiquitin-protein ligase complexes. Embryos are anemic and die around day 12.5 post- coitum (dpc). Primitive erythrocytes are found, but definitive erythropoiesis is absent. Fetal liver myeloid progenitors, although present based on the expression of lineage specific markers, fail to respond to erythropoietin (Epo), thrombopoietin (Thpo), interleukin-3 (Il3), or granulocyte and macrophage colony-stimulating factor 1 (Csf1 and Csf2). Fetal liver BFU-E and CFU-E colonies are completely absent. However, multilineage hematopoietic stem cells (CD34(low), c-kit(pos)) can be found, and B-lymphopoiesis appears intact. Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Sequence=AAB41327.1; Type=Frameshift; Evidence=; nucleotide binding activation of MAPKK activity microglial cell activation adaptive immune response immune system process protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol cytoskeleton plasma membrane caveola focal adhesion chromatin organization protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process response to oxidative stress signal transduction enzyme linked receptor protein signaling pathway G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration JAK-STAT cascade tyrosine phosphorylation of STAT protein protein C-terminus binding positive regulation of cell proliferation negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to oxidative stress hormone-mediated signaling pathway negative regulation of cardiac muscle cell apoptotic process positive regulation of cell-substrate adhesion positive regulation of receptor biosynthetic process endomembrane system positive regulation of phosphatidylinositol 3-kinase signaling membrane kinase activity phosphorylation nuclear matrix transferase activity peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway protein kinase binding heme binding negative regulation of cell-cell adhesion myeloid cell differentiation cell differentiation erythrocyte differentiation positive regulation of cell migration axon regeneration type 1 angiotensin receptor binding mineralocorticoid receptor signaling pathway positive regulation of insulin secretion response to lipopolysaccharide positive regulation of phosphoprotein phosphatase activity positive regulation of interleukin-1 beta production positive regulation of tumor necrosis factor production acetylcholine receptor binding response to hydroperoxide tumor necrosis factor-mediated signaling pathway host programmed cell death induced by symbiont response to tumor necrosis factor post-embryonic hemopoiesis histone kinase activity (H3-Y41 specific) histone H3-Y41 phosphorylation intracellular signal transduction interleukin-12-mediated signaling pathway cellular response to interleukin-3 SH2 domain binding histone binding positive regulation of tyrosine phosphorylation of STAT protein positive regulation of tumor necrosis factor biosynthetic process identical protein binding activation of Janus kinase activity positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of DNA binding negative regulation of DNA binding negative regulation of neuron apoptotic process phosphatidylinositol 3-kinase binding insulin receptor substrate binding innate immune response membrane raft positive regulation of MHC class II biosynthetic process regulation of nitric oxide biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation negative regulation of heart contraction positive regulation of transcription from RNA polymerase II promoter response to antibiotic protein autophosphorylation metal ion binding platelet-derived growth factor receptor signaling pathway positive regulation of interleukin-1 beta biosynthetic process regulation of inflammatory response positive regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation modulation of synaptic transmission positive regulation of cell activation positive regulation of sequence-specific DNA binding transcription factor activity peptide hormone receptor binding positive regulation of nitric-oxide synthase biosynthetic process interferon-gamma-mediated signaling pathway growth hormone receptor signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway positive regulation of growth hormone receptor signaling pathway negative regulation of cell death mammary gland epithelium development response to interleukin-12 cellular response to lipopolysaccharide cellular response to dexamethasone stimulus response to granulocyte macrophage colony-stimulating factor extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway postsynapse glutamatergic synapse postsynapse to nucleus signaling pathway positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of epithelial cell apoptotic process positive regulation of vascular smooth muscle cell proliferation positive regulation of apoptotic signaling pathway uc008hdb.1 uc008hdb.2 uc008hdb.3 uc008hdb.4 
ENSMUST00000065797.7 Chst1 ENSMUST00000065797.7 carbohydrate sulfotransferase 1, transcript variant 2 (from RefSeq NM_023850.2) CHST1_MOUSE ENSMUST00000065797.1 ENSMUST00000065797.2 ENSMUST00000065797.3 ENSMUST00000065797.4 ENSMUST00000065797.5 ENSMUST00000065797.6 Gst1 NM_023850 Q9D0K5 Q9EQC0 uc008lfk.1 uc008lfk.2 uc008lfk.3 uc008lfk.4 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit [->3(6- sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer (By similarity). Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain (PubMed:24152993). Involved in biosynthesis of 6- sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking (PubMed:23254996) (By similarity). Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures (By similarity). Reaction=3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'- bisphosphate + keratan 6'-sulfate.; EC=2.8.2.21; Evidence=; Glycan metabolism. Golgi apparatus membrane ; Single- pass type II membrane protein Broadly expressed with highest levels in central nervous system. Expressed in cortex (at protein level) (PubMed:24152993, PubMed:23254996). Expressed in high endothelial venules in peripheral lymph nodes, mesenteric lymph nodes and Peyer's patches (PubMed:23254996). Expressed in cortex and cerebellum throughout the postnatal period (at protein level). Mutant mice are born at the expected Mendelian rate and have normal developmental and reproductive potential. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. Golgi membrane N-acetylglucosamine 6-O-sulfotransferase activity Golgi apparatus trans-Golgi network carbohydrate metabolic process galactose metabolic process N-acetylglucosamine metabolic process sulfur compound metabolic process inflammatory response sulfotransferase activity membrane integral component of membrane transferase activity keratan sulfate metabolic process keratan sulfotransferase activity uc008lfk.1 uc008lfk.2 uc008lfk.3 uc008lfk.4 
ENSMUST00000065806.5 Yy2 ENSMUST00000065806.5 Yy2 transcription factor (from RefSeq NM_001098723.1) ENSMUST00000065806.1 ENSMUST00000065806.2 ENSMUST00000065806.3 ENSMUST00000065806.4 NM_001098723 Q3TTC2 Q8CBG3 TYY2_MOUSE uc012hrb.1 uc012hrb.2 Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation. Nucleus Weakly expressed by neuronal and glial cells in the cerebral cortex. Expressed by Purkinje cells and in the granular layers of the cerebellum. Expressed in all layers of spermatocytes in testis but not detected in sperm cells. The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene Mbtps2. Belongs to the YY transcription factor family. nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding nucleic acid binding DNA binding nucleus transcription factor complex regulation of transcription from RNA polymerase II promoter PcG protein complex sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc012hrb.1 uc012hrb.2 
ENSMUST00000065826.5 Gm4792 ENSMUST00000065826.5 predicted gene 4792 (from RefSeq NR_033209.1) ENSMUST00000065826.1 ENSMUST00000065826.2 ENSMUST00000065826.3 ENSMUST00000065826.4 NR_033209 uc007gvr.1 uc007gvr.2 uc007gvr.3 uc007gvr.4 uc007gvr.1 uc007gvr.2 uc007gvr.3 uc007gvr.4 
ENSMUST00000065841.5 Btnl4 ENSMUST00000065841.5 butyrophilin-like 4 (from RefSeq NM_030746.2) A2CG29 A2CG29_MOUSE Btn3a3 Btnl4 ENSMUST00000065841.1 ENSMUST00000065841.2 ENSMUST00000065841.3 ENSMUST00000065841.4 NM_030746 RP23-24A13.3-001 uc012apz.1 uc012apz.2 Membrane ; Single- pass type I membrane protein Belongs to the immunoglobulin superfamily. BTN/MOG family. receptor binding external side of plasma membrane membrane integral component of membrane regulation of immune response T cell receptor signaling pathway uc012apz.1 uc012apz.2 
ENSMUST00000065856.8 Hunk ENSMUST00000065856.8 hormonally upregulated Neu-associated kinase (from RefSeq NM_015755.2) ENSMUST00000065856.1 ENSMUST00000065856.2 ENSMUST00000065856.3 ENSMUST00000065856.4 ENSMUST00000065856.5 ENSMUST00000065856.6 ENSMUST00000065856.7 HUNK_MOUSE Makv NM_015755 O88866 uc007zwi.1 uc007zwi.2 uc007zwi.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity intracellular signal transduction uc007zwi.1 uc007zwi.2 uc007zwi.3 
ENSMUST00000065865.10 Thoc7 ENSMUST00000065865.10 THO complex 7, transcript variant 21 (from RefSeq NR_189661.1) ENSMUST00000065865.1 ENSMUST00000065865.2 ENSMUST00000065865.3 ENSMUST00000065865.4 ENSMUST00000065865.5 ENSMUST00000065865.6 ENSMUST00000065865.7 ENSMUST00000065865.8 ENSMUST00000065865.9 NR_189661 Nif3l1bp1 Q3UIA6 Q7TMY4 Q80VT4 Q9CQ50 THOC7_MOUSE uc007sge.1 uc007sge.2 uc007sge.3 uc007sge.4 Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling (By similarity). Interacts with NIF3L1 (PubMed:12951069). Interacts with THOC5 (By similarity). Cytoplasm Nucleus Nucleus speckle Note=Interaction with THOC5 is required for nuclear localization. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TMY4-1; Sequence=Displayed; Name=2; IsoId=Q7TMY4-2; Sequence=VSP_029326; Ubiquitously expressed. Expressed at low levels in testis between P3 and P14. Expression in testis increases at P20 and reaches maximum levels in adult. Belongs to the THOC7 family. Sequence=AAH42209.1; Type=Erroneous initiation; Evidence=; transcription export complex THO complex THO complex part of transcription export complex nuclear chromosome, telomeric region RNA binding protein binding nucleus cytoplasm cytosol mRNA processing mRNA export from nucleus RNA splicing nuclear speck viral mRNA export from host cell nucleus mRNA transport uc007sge.1 uc007sge.2 uc007sge.3 uc007sge.4 
ENSMUST00000065871.14 Zfp229 ENSMUST00000065871.14 zinc finger protein 229 (from RefSeq NM_001164676.1) E9PWT2 E9PWT2_MOUSE ENSMUST00000065871.1 ENSMUST00000065871.10 ENSMUST00000065871.11 ENSMUST00000065871.12 ENSMUST00000065871.13 ENSMUST00000065871.2 ENSMUST00000065871.3 ENSMUST00000065871.4 ENSMUST00000065871.5 ENSMUST00000065871.6 ENSMUST00000065871.7 ENSMUST00000065871.8 ENSMUST00000065871.9 NM_001164676 Zfp229 uc012aln.1 uc012aln.2 uc012aln.3 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc012aln.1 uc012aln.2 uc012aln.3 
ENSMUST00000065878.5 4930597O21Rik ENSMUST00000065878.5 4930597O21Rik (from geneSymbol) AK087755 ENSMUST00000065878.1 ENSMUST00000065878.2 ENSMUST00000065878.3 ENSMUST00000065878.4 uc009cev.1 uc009cev.2 uc009cev.3 uc009cev.4 uc009cev.1 uc009cev.2 uc009cev.3 uc009cev.4 
ENSMUST00000065887.14 Kifbp ENSMUST00000065887.14 kinesin family binding protein (from RefSeq NM_028197.2) ENSMUST00000065887.1 ENSMUST00000065887.10 ENSMUST00000065887.11 ENSMUST00000065887.12 ENSMUST00000065887.13 ENSMUST00000065887.2 ENSMUST00000065887.3 ENSMUST00000065887.4 ENSMUST00000065887.5 ENSMUST00000065887.6 ENSMUST00000065887.7 ENSMUST00000065887.8 ENSMUST00000065887.9 KBP_MOUSE Kbp Kiaa1279 Kif1bp Kifbp NM_028197 Q3TYD0 Q5BKR5 Q6ZPU9 Q7TPE0 Q80VQ5 Q8BZE2 Q8CFS7 uc007fhk.1 uc007fhk.2 Required for neuronal development and differentiation. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. Interacts with KIF1B. Interacts with STMN2. Cytoplasm, cytoskeleton Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6ZPU9-1; Sequence=Displayed; Name=2; IsoId=Q6ZPU9-2; Sequence=VSP_015214, VSP_015215; Name=3; IsoId=Q6ZPU9-3; Sequence=VSP_015213; In the embryo it is expressed in cortical neurons; expression increases during neuronal development. Belongs to the KIF-binding protein family. Sequence=AAH90974.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC98130.1; Type=Erroneous initiation; Evidence=; in utero embryonic development cytoplasm mitochondrion cytoskeleton mitochondrial transport multicellular organism development nervous system development kinesin binding cell differentiation uc007fhk.1 uc007fhk.2 
ENSMUST00000065894.7 Slc51b ENSMUST00000065894.7 solute carrier family 51, beta subunit (from RefSeq NM_178933.2) ENSMUST00000065894.1 ENSMUST00000065894.2 ENSMUST00000065894.3 ENSMUST00000065894.4 ENSMUST00000065894.5 ENSMUST00000065894.6 NM_178933 OSTB_MOUSE Ostb Q14BU3 Q3V4C1 Q80WK2 uc009qdg.1 uc009qdg.2 uc009qdg.3 Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:15563450, PubMed:16317684, PubMed:17650074, PubMed:22535958). The Ost-alpha/Ost-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684, PubMed:17650074, PubMed:22535958). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (PubMed:16317684). Can also transport steroids such as estrone 3- sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (By similarity). Able to transport eicosanoids such as prostaglandin E2 (By similarity). Modulates SLC51A glycosylation, membrane trafficking and stability activities (PubMed:15563450). Reaction=taurocholate(out) = taurocholate(in); Xref=Rhea:RHEA:71703, ChEBI:CHEBI:36257; Evidence= Reaction=tauroursodeoxycholate(out) = tauroursodeoxycholate(in); Xref=Rhea:RHEA:71843, ChEBI:CHEBI:132028; Evidence=; Reaction=glycoursodeoxycholate(out) = glycoursodeoxycholate(in); Xref=Rhea:RHEA:71847, ChEBI:CHEBI:132030; Evidence=; Reaction=glycocholate(out) = glycocholate(in); Xref=Rhea:RHEA:71851, ChEBI:CHEBI:29746; Evidence=; Reaction=taurochenodeoxycholate(out) = taurochenodeoxycholate(in); Xref=Rhea:RHEA:71855, ChEBI:CHEBI:9407; Evidence=; Reaction=glycochenodeoxycholate(out) = glycochenodeoxycholate(in); Xref=Rhea:RHEA:71859, ChEBI:CHEBI:36252; Evidence=; Reaction=taurodeoxycholate(out) = taurodeoxycholate(in); Xref=Rhea:RHEA:71863, ChEBI:CHEBI:36261; Evidence=; Reaction=glycodeoxycholate(out) = glycodeoxycholate(in); Xref=Rhea:RHEA:71867, ChEBI:CHEBI:82982; Evidence=; Reaction=prostaglandin E2(out) = prostaglandin E2(in); Xref=Rhea:RHEA:50984, ChEBI:CHEBI:606564; Evidence=; Reaction=estrone 3-sulfate(out) = estrone 3-sulfate(in); Xref=Rhea:RHEA:71835, ChEBI:CHEBI:60050; Evidence=; Reaction=dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 3-sulfate(in); Xref=Rhea:RHEA:71839, ChEBI:CHEBI:57905; Evidence=; Interacts with SLC51A. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit; induces the transport of SLC51A from the reticulum endoplasmic to the plasma membrane. Cell membrane ingle-pass membrane protein te=Mainly restricted to the lateral and basal membranes of ileal enterocytes. Present at high level in ileum. In ileum, it is restricted to the apical domain on the mature villus enterocytes with little detectable expression in the goblet cells or crypt enterocytes (at protein level). Expressed in kidney but not in heart, brain, liver, spleen, embryo, lung, thymus, ovary nor testis. Positively regulated via the bile acid-activated nuclear receptor farnesoid X receptor (NR1H4/FXR). The transmembrane domain (TM) is the major site of interaction with SLC51A. The extracellular-membrane interface is absolutely required for transport activity. The intracellular-membrane interface is necessary for establishing the correct membrane orientation that is essential for the heterodimer Ost-alpha/Ost-beta complex formation and transport activity at the cell membrane surface. Belongs to the OST-beta family. Sequence=BAE20418.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; protein binding plasma membrane bile acid transmembrane transporter activity bile acid and bile salt transport membrane integral component of membrane basolateral plasma membrane transmembrane transporter activity regulation of protein stability bile acid secretion macromolecular complex protein heterodimerization activity transmembrane transport positive regulation of protein glycosylation positive regulation of protein exit from endoplasmic reticulum organic substance transport positive regulation of protein targeting to membrane uc009qdg.1 uc009qdg.2 uc009qdg.3 
ENSMUST00000065900.10 Hhipl2 ENSMUST00000065900.10 hedgehog interacting protein-like 2, transcript variant 1 (from RefSeq NM_030175.5) ENSMUST00000065900.1 ENSMUST00000065900.2 ENSMUST00000065900.3 ENSMUST00000065900.4 ENSMUST00000065900.5 ENSMUST00000065900.6 ENSMUST00000065900.7 ENSMUST00000065900.8 ENSMUST00000065900.9 HIPL2_MOUSE Hhip3 Kiaa1822l NM_030175 Q9D2G9 uc012bop.1 uc012bop.2 uc012bop.3 uc012bop.4 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D2G9-1; Sequence=Displayed; Name=2; IsoId=Q9D2G9-2; Sequence=VSP_030459; Belongs to the HHIP family. molecular_function catalytic activity cellular_component extracellular region biological_process uc012bop.1 uc012bop.2 uc012bop.3 uc012bop.4 
ENSMUST00000065904.5 Hs6st3 ENSMUST00000065904.5 heparan sulfate 6-O-sulfotransferase 3 (from RefSeq NM_015820.3) ENSMUST00000065904.1 ENSMUST00000065904.2 ENSMUST00000065904.3 ENSMUST00000065904.4 H6ST3_MOUSE NM_015820 Q148Q1 Q9QYK4 uc007uzn.1 uc007uzn.2 uc007uzn.3 uc007uzn.4 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:56604, Rhea:RHEA- COMP:9830, Rhea:RHEA-COMP:14621, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:140604; Kinetic parameters: KM=20 uM for CDSNS-heparin ; KM=20 uM for NS-heparosan ; Membrane ; Single-pass type II membrane protein Ubiquitously expressed. Belongs to the sulfotransferase 6 family. sulfotransferase activity heparan sulfate proteoglycan biosynthetic process, enzymatic modification membrane integral component of membrane transferase activity heparan sulfate 6-O-sulfotransferase activity uc007uzn.1 uc007uzn.2 uc007uzn.3 uc007uzn.4 
ENSMUST00000065906.9 Ggcx ENSMUST00000065906.9 gamma-glutamyl carboxylase, transcript variant 9 (from RefSeq NR_177214.1) ENSMUST00000065906.1 ENSMUST00000065906.2 ENSMUST00000065906.3 ENSMUST00000065906.4 ENSMUST00000065906.5 ENSMUST00000065906.6 ENSMUST00000065906.7 ENSMUST00000065906.8 NR_177214 Q3UXN5 Q8CCB3 Q9QYC7 VKGC_MOUSE uc009cio.1 uc009cio.2 uc009cio.3 uc009cio.4 Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide (By similarity). Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (bglap and bglap2) or matrix Gla protein (MGP) (PubMed:25264202). Reaction=2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O = CO2 + L-glutamyl-[protein] + O2 + phylloquinol; Xref=Rhea:RHEA:45140, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:11094, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15759, ChEBI:CHEBI:16526, ChEBI:CHEBI:28433, ChEBI:CHEBI:29973, ChEBI:CHEBI:84990; EC=4.1.1.90; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:45142; Evidence=; Monomer (By similarity). May interact with CALU (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Embryonic lethality between 9.5-18 dpc due to massive hemorrhage (PubMed:17327402). Conditional deletion in osteoblasts leads to altered glucose metabolism due to inability to carboxylate osteocalcin (bglap and bglap2) (PubMed:25264202). The vitamin K-dependent protein substrates of carboxylase have usually a propeptide that binds to a high-affinity site on the carboxylase. CO(2), O(2) and reduced vitamin K are cosubstrates. Belongs to the vitamin K-dependent gamma-carboxylase family. endoplasmic reticulum endoplasmic reticulum membrane gamma-glutamyl carboxylase activity membrane integral component of membrane lyase activity peptidyl-glutamic acid carboxylation vitamin binding intracellular membrane-bounded organelle uc009cio.1 uc009cio.2 uc009cio.3 uc009cio.4 
ENSMUST00000065916.14 Tg ENSMUST00000065916.14 thyroglobulin (from RefSeq NM_009375.2) ENSMUST00000065916.1 ENSMUST00000065916.10 ENSMUST00000065916.11 ENSMUST00000065916.12 ENSMUST00000065916.13 ENSMUST00000065916.2 ENSMUST00000065916.3 ENSMUST00000065916.4 ENSMUST00000065916.5 ENSMUST00000065916.6 ENSMUST00000065916.7 ENSMUST00000065916.8 ENSMUST00000065916.9 NM_009375 O08710 O88590 Q2NKY1 Q9QWY7 THYG_MOUSE Tgn uc007wap.1 uc007wap.2 uc007wap.3 uc007wap.4 Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (Probable). One dimer produces 7 thyroid hormone molecules (By similarity). Monomer (PubMed:12782676). Homodimer (via ChEL region); occurs in the endoplasmic reticulum and is required for export to the Golgi apparatus (PubMed:19276074, PubMed:12782676). Homooligomer; disulfide- linked; stored in this form in the thyroid follicle lumen (By similarity). Secreted te=Secreted into the thyroid follicle lumen (PubMed:12782676). Localizes to colloid globules, a structure formed in the thyroid follicle lumen consisting of cross-linked TG arranged in concentric layers (PubMed:12782676). Specifically expressed in the thyroid gland. The cholinesterase-like (ChEL) region is required for dimerization and export from the endoplasmic reticulum. Iodinated on tyrosine residues by TPO (By similarity). There are 4 pairs of iodinated tyrosines used for coupling: acceptor Tyr-25 is coupled to donor Tyr-150 or Tyr-235, acceptor Tyr-2572 is coupled to donor Tyr-2539, acceptor Tyr-2764 in monomer 1 is coupled to donor Tyr- 2764 in monomer 2 and acceptor Tyr-1310 in monomer 1 is coupled to donor Tyr-109 in monomer 2 (By similarity). Sulfated tyrosines are desulfated during iodination. Undergoes sequential proteolysis by cathepsins to release thyroxine (T4) and triiodothyronine (T3) hormones (PubMed:12782676). In the thyroid follicle lumen, cross-linked TG (storage form) is solubilized by limited proteolysis mediated by cathepsins CTSB and/or CTSL (PubMed:12782676). Partially cleaved TG is further processed by CTSK/cathepsin K and/or CTSL resulting in the release of T4 (PubMed:12782676). Following endocytosis, further processing occurs leading to the release of T3 and more T4 hormones (Probable). Note=Congenital goiter (cog) is caused by a hypertrophy of the thyroid gland (goiter). Mice have reduced growth rate, hypothyroidism due to reduced production of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), and lack colloid globules, a structure in the thyroid follicle lumen that is enriched in Tg/thyroglobulin. Belongs to the type-B carboxylesterase/lipase family. The cholinesterase-like (ChEL) region lacks the Ser residue of the catalytic triad suggesting that it has no esterase activity. receptor binding hormone activity extracellular region extracellular space endoplasmic reticulum Golgi apparatus thyroid hormone generation signal transduction response to pH iodide transport thyroid gland development regulation of myelination macromolecular complex thyroid hormone metabolic process hormone biosynthetic process protein homodimerization activity anion binding macromolecular complex binding transcytosis perinuclear region of cytoplasm chaperone binding uc007wap.1 uc007wap.2 uc007wap.3 uc007wap.4 
ENSMUST00000065917.16 Nap1l1 ENSMUST00000065917.16 nucleosome assembly protein 1-like 1, transcript variant 2 (from RefSeq NM_015781.5) ENSMUST00000065917.1 ENSMUST00000065917.10 ENSMUST00000065917.11 ENSMUST00000065917.12 ENSMUST00000065917.13 ENSMUST00000065917.14 ENSMUST00000065917.15 ENSMUST00000065917.2 ENSMUST00000065917.3 ENSMUST00000065917.4 ENSMUST00000065917.5 ENSMUST00000065917.6 ENSMUST00000065917.7 ENSMUST00000065917.8 ENSMUST00000065917.9 NM_015781 NP1L1_MOUSE Nrp P28656 Q3UL14 uc007hac.1 uc007hac.2 uc007hac.3 uc007hac.4 Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (PubMed:29490266). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (PubMed:29490266). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (PubMed:29490266). Homodimer. The dimer binds strongly and sequentially to single and double H2A-H2B heterodimers. Interacts with ERCC6; this interaction increases ERCC6 processivity. Interacts with RAD54 (By similarity). Interacts with SETD1A (PubMed:29490266). P28656; Q9WVS7: Map2k5; NbExp=20; IntAct=EBI-645055, EBI-446144; Nucleus Cytoplasm Melanosome Highly expressed in the brain (at protein level) (PubMed:29490266). High expression in cerebral cortex, not in cerebellar cortex. During brain development, expression decreases from 12 dpc to P0. Expressed predominantly but not restricted in the ventricular zone (VZ)/subventricular zone (SVZ), and peak expression is observed at 12.5 dpc, in which the cerebral cortex consists primarily of neural progenitor cells (NPCs). At 15.5 dpc, the expression decreases in the cerebral cortical plate. At 18.5 dpc, when the embryonic neurogenesis period nears its end, the expression throughout the cerebral cortex is lower than that at 12.5 dpc (at protein level). The NAP1L motif is required for the histone chaperone activity. The acidic domains are probably involved in the interaction with histones. Polyglycylated by TTLL10 on glutamate residues, resulting in polyglycine chains on the gamma-carboxyl group. Both polyglutamylation and polyglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Polyglutamylated by TTLL4 on glutamate residues, resulting in polyglutamate chains on the gamma-carboxyl group. Both polyglutamylation and polyglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Mice show abnormal embryonic neurogenesis. Belongs to the nucleosome assembly protein (NAP) family. protein binding nucleus cytoplasm nucleosome assembly nervous system development kinase binding melanosome neuron projection positive regulation of neurogenesis positive regulation of neural precursor cell proliferation uc007hac.1 uc007hac.2 uc007hac.3 uc007hac.4 
ENSMUST00000065927.6 Tnfaip6 ENSMUST00000065927.6 tumor necrosis factor alpha induced protein 6 (from RefSeq NM_009398.2) ENSMUST00000065927.1 ENSMUST00000065927.2 ENSMUST00000065927.3 ENSMUST00000065927.4 ENSMUST00000065927.5 NM_009398 Q3USX6 Q3USX6_MOUSE Tnfaip6 uc008jqp.1 uc008jqp.2 uc008jqp.3 Secreted Lacks conserved residue(s) required for the propagation of feature annotation. hyaluronic acid binding extracellular space cell adhesion positive regulation of cell migration ovulation negative regulation of inflammatory response uc008jqp.1 uc008jqp.2 uc008jqp.3 
ENSMUST00000065938.15 Impa1 ENSMUST00000065938.15 inositol (myo)-1(or 4)-monophosphatase 1, transcript variant 1 (from RefSeq NM_018864.6) ENSMUST00000065938.1 ENSMUST00000065938.10 ENSMUST00000065938.11 ENSMUST00000065938.12 ENSMUST00000065938.13 ENSMUST00000065938.14 ENSMUST00000065938.2 ENSMUST00000065938.3 ENSMUST00000065938.4 ENSMUST00000065938.5 ENSMUST00000065938.6 ENSMUST00000065938.7 ENSMUST00000065938.8 ENSMUST00000065938.9 Impa1 NM_018864 Q924B0 Q924B0_MOUSE uc008opo.1 uc008opo.2 uc008opo.3 uc008opo.4 Reaction=a myo-inositol phosphate + H2O = myo-inositol + phosphate; Xref=Rhea:RHEA:24056, ChEBI:CHEBI:15377, ChEBI:CHEBI:17268, ChEBI:CHEBI:43474, ChEBI:CHEBI:84139; EC=3.1.3.25; Evidence= Reaction=alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate; Xref=Rhea:RHEA:29315, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58336; EC=3.1.3.94; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2. Homodimer. Cytoplasm Belongs to the inositol monophosphatase superfamily. magnesium ion binding cytoplasm inositol biosynthetic process phosphatidylinositol biosynthetic process phosphate-containing compound metabolic process signal transduction inositol monophosphate 1-phosphatase activity hydrolase activity manganese ion binding lithium ion binding identical protein binding protein homodimerization activity phosphatidylinositol phosphorylation inositol phosphate dephosphorylation metal ion binding inositol monophosphate 3-phosphatase activity inositol monophosphate 4-phosphatase activity inositol monophosphate phosphatase activity uc008opo.1 uc008opo.2 uc008opo.3 uc008opo.4 
ENSMUST00000065941.12 Usp21 ENSMUST00000065941.12 ubiquitin specific peptidase 21 (from RefSeq NM_013919.4) E9PUE2 E9PUE2_MOUSE ENSMUST00000065941.1 ENSMUST00000065941.10 ENSMUST00000065941.11 ENSMUST00000065941.2 ENSMUST00000065941.3 ENSMUST00000065941.4 ENSMUST00000065941.5 ENSMUST00000065941.6 ENSMUST00000065941.7 ENSMUST00000065941.8 ENSMUST00000065941.9 NM_013919 Usp21 uc011wwa.1 uc011wwa.2 uc011wwa.3 uc011wwa.4 Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence= Belongs to the peptidase C19 family. thiol-dependent ubiquitin-specific protease activity nucleoplasm cytosol plasma membrane proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity NEDD8-specific protease activity neuron projection development thiol-dependent ubiquitinyl hydrolase activity uc011wwa.1 uc011wwa.2 uc011wwa.3 uc011wwa.4 
ENSMUST00000065956.5 Gm5444 ENSMUST00000065956.5 Gm5444 (from geneSymbol) AK030184 ENSMUST00000065956.1 ENSMUST00000065956.2 ENSMUST00000065956.3 ENSMUST00000065956.4 uc288kkm.1 uc288kkm.2 uc288kkm.1 uc288kkm.2 
ENSMUST00000065957.7 Syt5 ENSMUST00000065957.7 synaptotagmin V, transcript variant 2 (from RefSeq NM_001360422.1) ENSMUST00000065957.1 ENSMUST00000065957.2 ENSMUST00000065957.3 ENSMUST00000065957.4 ENSMUST00000065957.5 ENSMUST00000065957.6 NM_001360422 Q9R0N5 SYT5_MOUSE Syt9 uc009exy.1 uc009exy.2 May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. ; Homodimer (By similarity). Interacts with both alpha- and beta-tubulin (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein Recycling endosome membrane ; Single-pass membrane protein Note=In mast cells, localizes to the endocytic recycling compartment. Belongs to the synaptotagmin family. SNARE binding phosphatidylserine binding calcium ion binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding endosome plasma membrane regulation of dopamine secretion membrane integral component of membrane synaptic vesicle exocytosis vesicle-mediated transport calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis syntaxin binding cell junction clathrin binding axon synaptic vesicle membrane dense core granule cytoplasmic vesicle neuron projection neuronal cell body synapse metal ion binding protein heterodimerization activity perinuclear region of cytoplasm synaptic vesicle endocytosis calcium ion-regulated exocytosis of neurotransmitter recycling endosome membrane exocytic vesicle cellular response to calcium ion integral component of neuronal dense core vesicle membrane proximal neuron projection uc009exy.1 uc009exy.2 
ENSMUST00000065967.14 Pld5 ENSMUST00000065967.14 phospholipase D family member 5, transcript variant 1 (from RefSeq NM_176916.4) ENSMUST00000065967.1 ENSMUST00000065967.10 ENSMUST00000065967.11 ENSMUST00000065967.12 ENSMUST00000065967.13 ENSMUST00000065967.2 ENSMUST00000065967.3 ENSMUST00000065967.4 ENSMUST00000065967.5 ENSMUST00000065967.6 ENSMUST00000065967.7 ENSMUST00000065967.8 ENSMUST00000065967.9 NM_176916 PLD5_MOUSE Q3UNN8 Q3UVW3 Q497Q7 uc007dtw.1 uc007dtw.2 uc007dtw.3 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UNN8-1; Sequence=Displayed; Name=2; IsoId=Q3UNN8-2; Sequence=VSP_025729; Name=3; IsoId=Q3UNN8-3; Sequence=VSP_025728; Belongs to the phospholipase D family. In contrast to other members of the family, it lacks the conserved active sites, suggesting that it has no phospholipase activity. Sequence=AAI00429.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; molecular_function catalytic activity cellular_component biological_process membrane integral component of membrane uc007dtw.1 uc007dtw.2 uc007dtw.3 
ENSMUST00000065970.6 Kcnip1 ENSMUST00000065970.6 Kv channel-interacting protein 1, transcript variant B (from RefSeq NM_027398.5) ENSMUST00000065970.1 ENSMUST00000065970.2 ENSMUST00000065970.3 ENSMUST00000065970.4 ENSMUST00000065970.5 KCIP1_MOUSE Kchip1 NM_027398 Q5SSA3 Q6DTJ1 Q8BGJ4 Q8C4K4 Q8CGL1 Q8K1U1 Q8K3M2 Q9JJ57 uc007iko.1 uc007iko.2 uc007iko.3 uc007iko.4 uc007iko.5 Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND2/Kv4.2 currents (PubMed:14572458). In vitro, modulates KCND1/Kv4.1 currents (By similarity). Increases the presence of KCND2 at the cell surface. Component of heteromultimeric potassium channels (PubMed:19713751). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (PubMed:19713751). Part of a heterooctamer composed of the tetrameric channel and four KCNIP1 chains (By similarity). Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. Self-associates to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner (By similarity). Cell membrane ; Peripheral membrane protein Cytoplasm Cell projection, dendrite Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=A, Kchip1.2, KCHIP1b; IsoId=Q9JJ57-1; Sequence=Displayed; Name=2; Synonyms=Kchip1.1, KCHP1a; IsoId=Q9JJ57-2; Sequence=VSP_015047; Name=3; Synonyms=Kchip1.2; IsoId=Q9JJ57-3; Sequence=VSP_015045; Name=4; IsoId=Q9JJ57-4; Sequence=VSP_015046; Expressed in brain. Found in a subpopulation of neurons widely distributed and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei. Belongs to the recoverin family. Sequence=AAN77492.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; voltage-gated ion channel activity potassium channel activity calcium ion binding cytoplasm plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex potassium channel regulator activity membrane dendrite extrinsic component of cytoplasmic side of plasma membrane potassium channel complex regulation of ion transmembrane transport cell projection neuronal cell body ion channel binding positive regulation of action potential metal ion binding protein heterodimerization activity protein N-terminus binding potassium ion transmembrane transport regulation of potassium ion transmembrane transport uc007iko.1 uc007iko.2 uc007iko.3 uc007iko.4 uc007iko.5 
ENSMUST00000065978.9 Gtsf2 ENSMUST00000065978.9 gametocyte specific factor 2 (from RefSeq NM_177631.4) BC048502 ENSMUST00000065978.1 ENSMUST00000065978.2 ENSMUST00000065978.3 ENSMUST00000065978.4 ENSMUST00000065978.5 ENSMUST00000065978.6 ENSMUST00000065978.7 ENSMUST00000065978.8 Gtsf2 NM_177631 Q80Y74 Q80Y74_MOUSE uc007xye.1 uc007xye.2 uc007xye.3 molecular_function cellular_component biological_process uc007xye.1 uc007xye.2 uc007xye.3 
ENSMUST00000065987.14 Abat ENSMUST00000065987.14 4-aminobutyrate aminotransferase, transcript variant 1 (from RefSeq NM_172961.3) Abat ENSMUST00000065987.1 ENSMUST00000065987.10 ENSMUST00000065987.11 ENSMUST00000065987.12 ENSMUST00000065987.13 ENSMUST00000065987.2 ENSMUST00000065987.3 ENSMUST00000065987.4 ENSMUST00000065987.5 ENSMUST00000065987.6 ENSMUST00000065987.7 ENSMUST00000065987.8 ENSMUST00000065987.9 GABT_MOUSE Gabat NM_172961 P61922 Q8BZA3 uc007yco.1 uc007yco.2 uc007yco.3 uc007yco.4 The encoded gene product is responsible for catabolism of gamma-aminobutyric acid (GABA), a mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. Deficiency of this encoded protein includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. Reaction=2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde; Xref=Rhea:RHEA:23352, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57706, ChEBI:CHEBI:59888; EC=2.6.1.19; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23353; Evidence=; Reaction=(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3- oxopropanoate + L-glutamate; Xref=Rhea:RHEA:13993, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57700, ChEBI:CHEBI:58655; EC=2.6.1.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13994; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 1 [2Fe-2S] cluster per homodimer. ; Homodimer; disulfide-linked. Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P61922-1; Sequence=Displayed; Name=2; IsoId=P61922-2; Sequence=VSP_012005; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. response to hypoxia catalytic activity 4-aminobutyrate transaminase activity mitochondrion mitochondrial matrix aging copulation locomotory behavior transaminase activity gamma-aminobutyric acid metabolic process gamma-aminobutyric acid biosynthetic process gamma-aminobutyric acid catabolic process response to iron ion negative regulation of gamma-aminobutyric acid secretion transferase activity cerebellum development pyridoxal phosphate binding positive regulation of heat generation positive regulation of insulin secretion 4-aminobutyrate transaminase complex succinate-semialdehyde dehydrogenase binding negative regulation of dopamine secretion 4-aminobutyrate:2-oxoglutarate transaminase activity response to nicotine exploration behavior neurotransmitter catabolic process response to cocaine response to drug protein homodimerization activity neuron projection response to ethanol negative regulation of blood pressure positive regulation of dopamine metabolic process metal ion binding (S)-3-amino-2-methylpropionate transaminase activity behavioral response to cocaine iron-sulfur cluster binding positive regulation of uterine smooth muscle contraction negative regulation of platelet aggregation positive regulation of inhibitory postsynaptic potential positive regulation of prolactin secretion positive regulation of aspartate secretion uc007yco.1 uc007yco.2 uc007yco.3 uc007yco.4 
ENSMUST00000066026.8 Cul9 ENSMUST00000066026.8 Cytoplasm (from UniProt E9QP09) AK147675 Cul9 E9QP09 E9QP09_MOUSE ENSMUST00000066026.1 ENSMUST00000066026.2 ENSMUST00000066026.3 ENSMUST00000066026.4 ENSMUST00000066026.5 ENSMUST00000066026.6 ENSMUST00000066026.7 uc289lnc.1 uc289lnc.2 Cytoplasm Belongs to the cullin family. microtubule cytoskeleton organization ubiquitin-dependent protein catabolic process regulation of mitotic nuclear division protein ubiquitination transferase activity cullin-RING ubiquitin ligase complex ubiquitin protein ligase binding metal ion binding uc289lnc.1 uc289lnc.2 
ENSMUST00000066038.4 Gm16568 ENSMUST00000066038.4 Gm16568 (from geneSymbol) AK143036 ENSMUST00000066038.1 ENSMUST00000066038.2 ENSMUST00000066038.3 uc292eqm.1 uc292eqm.2 uc292eqm.1 uc292eqm.2 
ENSMUST00000066039.8 Cstf2t ENSMUST00000066039.8 cleavage stimulation factor, 3' pre-RNA subunit 2, tau (from RefSeq NM_031249.2) CSTFT_MOUSE ENSMUST00000066039.1 ENSMUST00000066039.2 ENSMUST00000066039.3 ENSMUST00000066039.4 ENSMUST00000066039.5 ENSMUST00000066039.6 ENSMUST00000066039.7 Kiaa0689 NM_031249 Q6A016 Q8BHH7 Q8C3W7 Q8C7E9 Q8R2Y1 Q9EPU3 uc008her.1 uc008her.2 uc008her.3 uc008her.4 May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre- mRNAs. Nucleus Expressed in testes, where it is restricted to pachytene spermatocytes and spermatids, and in the brain (at protein level). Sequence=BAC39256.1; Type=Frameshift; Evidence=; Sequence=BAD32280.1; Type=Erroneous initiation; Evidence=; nucleic acid binding RNA binding mRNA binding nucleus nucleoplasm mRNA cleavage and polyadenylation specificity factor complex mRNA polyadenylation mRNA processing mRNA 3'-end processing pre-mRNA cleavage required for polyadenylation uc008her.1 uc008her.2 uc008her.3 uc008her.4 
ENSMUST00000066041.12 Shisa7 ENSMUST00000066041.12 shisa family member 7, transcript variant 1 (from RefSeq NM_172737.4) A0A172Q401 A0A172Q418 ENSMUST00000066041.1 ENSMUST00000066041.10 ENSMUST00000066041.11 ENSMUST00000066041.2 ENSMUST00000066041.3 ENSMUST00000066041.4 ENSMUST00000066041.5 ENSMUST00000066041.6 ENSMUST00000066041.7 ENSMUST00000066041.8 ENSMUST00000066041.9 NM_172737 Q3UMB3 Q8C3Q5 SHSA7_MOUSE Shisa7 uc009eyu.1 uc009eyu.2 uc009eyu.3 uc009eyu.4 Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain (PubMed:31601770). Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain (PubMed:31601770). May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall (Probable). May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses (Probable). Interacts with GABA(A)R (GABA type A receptor) subunits GABRA1, GABRA2 and GABRG2; the interaction is direct (PubMed:31601770). Does not interact with GABRB2 and GABRB3 subunits (PubMed:31601770). Interacts with AMPAR subunits GRIA1, GRIA2 and GRIA3 and AMPAR auxiliary proteins SHISA6 and SHISA7 in heterologous cells (PubMed:26623514, PubMed:29199957). Interacts (via PDZ-binding motif) with DLG4/PSD-95 (via PDZ domain)in heterologous cells; the interaction is direct (PubMed:29199957). Postsynaptic density membrane ; Single-pass type I membrane protein Note=Localizes at GABAergic inhibitory synapses and colocalizes with gephyrin in hippocampal neurons. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C3Q5-1; Sequence=Displayed; Name=2; IsoId=Q8C3Q5-2; Sequence=VSP_034790; Mainly expressed in neurons (PubMed:26623514, PubMed:29199957, PubMed:31601770). Highly expressed in brain structures including cortex, striatum, olfactory bulb, amygdala hippocampus CA1-3 and dentate gyrus (at protein level) (PubMed:26623514, PubMed:29199957, PubMed:31601770). Expressed in the cerebral cortex on 17 dpc and in olfactory bulb and hippocampus on postnatal day 1 (P1) (PubMed:26623514). Expression in hippocampus increases during postnatal development and reaches a plateau after 3 weeks (PubMed:29199957). Expression is high during prenatal development and decreases in the thalamus and brainstem during postnatal development (PubMed:26623514). The GRID (GABA(A)R-interacting domain) is critical for its subcellular localization and interaction with GABA(A)R. The PDZ-binding motif interacts with PDZ-domain of scaffolding protein DLG4 in heterologous cells. N-glycosylated. Knockout mice show a decrease in miniature inhibitory postsynaptic currents frequency, but not amplitude, in CA1 pyramidal neurons (PubMed:31601770). Mice show impaired acquisition of contextual fear memory without affecting auditory fear learning or anxiety (PubMed:29199957). Decreased long-term potentiation of hippocampal glutamatergic synapses (PubMed:29199957). Belongs to the shisa family. SHISA7 has been reported to interact with AMPAR subunit GRIA1 in heterologous conditions and in the brain (PubMed:26623514, PubMed:29199957). However, it was later demonstrated that SHISA7 does not colocalize neither interact with AMPAR, but with GABA(A)R (PubMed:31601770). Therefore additional experiments are needed to understand the discrepancy for SHISA7 function. Sequence=BAC39371.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding plasma membrane memory postsynaptic density membrane integral component of membrane cell junction AMPA glutamate receptor complex dendritic spine membrane ionotropic glutamate receptor binding synapse postsynaptic membrane regulation of short-term neuronal synaptic plasticity regulation of postsynaptic neurotransmitter receptor activity glutamatergic synapse asymmetric, glutamatergic, excitatory synapse integral component of postsynaptic specialization membrane positive regulation of long-term synaptic potentiation regulation of AMPA glutamate receptor clustering regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc009eyu.1 uc009eyu.2 uc009eyu.3 uc009eyu.4 
ENSMUST00000066049.7 Tmem200a ENSMUST00000066049.7 transmembrane protein 200A, transcript variant 1 (from RefSeq NM_029881.4) ENSMUST00000066049.1 ENSMUST00000066049.2 ENSMUST00000066049.3 ENSMUST00000066049.4 ENSMUST00000066049.5 ENSMUST00000066049.6 Kiaa1913 NM_029881 Q69Z67 Q8C817 Q8CCL5 T200A_MOUSE uc007erw.1 uc007erw.2 uc007erw.3 Membrane ; Multi-pass membrane protein Belongs to the TMEM200 family. Sequence=BAD32577.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc007erw.1 uc007erw.2 uc007erw.3 
ENSMUST00000066052.12 3110082I17Rik ENSMUST00000066052.12 RIKEN cDNA 3110082I17 gene, transcript variant 1 (from RefSeq NM_028469.4) CG050_MOUSE ENSMUST00000066052.1 ENSMUST00000066052.10 ENSMUST00000066052.11 ENSMUST00000066052.2 ENSMUST00000066052.3 ENSMUST00000066052.4 ENSMUST00000066052.5 ENSMUST00000066052.6 ENSMUST00000066052.7 ENSMUST00000066052.8 ENSMUST00000066052.9 G5E8F7 NM_028469 Q6PDQ0 Q9CXL3 uc009agk.1 uc009agk.2 uc009agk.3 Sequence=BAB29235.1; Type=Frameshift; Evidence=; cellular_component biological_process uc009agk.1 uc009agk.2 uc009agk.3 
ENSMUST00000066058.8 Mapkbp1 ENSMUST00000066058.8 mitogen-activated protein kinase binding protein 1, transcript variant 2 (from RefSeq NM_011941.3) A0A0A0MQA2 A0A0A0MQA2_MOUSE ENSMUST00000066058.1 ENSMUST00000066058.2 ENSMUST00000066058.3 ENSMUST00000066058.4 ENSMUST00000066058.5 ENSMUST00000066058.6 ENSMUST00000066058.7 Mapkbp1 NM_011941 uc008luw.1 uc008luw.2 uc008luw.3 uc008luw.4 cytoplasm negative regulation of I-kappaB kinase/NF-kappaB signaling mitotic spindle pole negative regulation of defense response to bacterium negative regulation of interleukin-8 secretion uc008luw.1 uc008luw.2 uc008luw.3 uc008luw.4 
ENSMUST00000066068.7 Smagp ENSMUST00000066068.7 small cell adhesion glycoprotein, transcript variant 6 (from RefSeq NR_104338.1) ENSMUST00000066068.1 ENSMUST00000066068.2 ENSMUST00000066068.3 ENSMUST00000066068.4 ENSMUST00000066068.5 ENSMUST00000066068.6 NR_104338 Q99KC7 SMAGP_MOUSE uc007xru.1 uc007xru.2 uc007xru.3 uc007xru.4 uc007xru.5 May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation (By similarity). Cell membrane ; Single-pass type III membrane protein Cytoplasmic vesicle membrane ; Single-pass type III membrane protein Note=Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions. Detected on cytoplasmic membranes in undifferentiated tumors. O-glycosylated. The O-glycan is modified with sialic acid residues (By similarity). Belongs to the SMAGP family. nucleoplasm plasma membrane membrane integral component of membrane cell junction cytoplasmic vesicle membrane cytoplasmic vesicle uc007xru.1 uc007xru.2 uc007xru.3 uc007xru.4 uc007xru.5 
ENSMUST00000066070.7 Eif3k ENSMUST00000066070.7 eukaryotic translation initiation factor 3, subunit K, transcript variant 1 (from RefSeq NM_028659.4) EIF3K_MOUSE ENSMUST00000066070.1 ENSMUST00000066070.2 ENSMUST00000066070.3 ENSMUST00000066070.4 ENSMUST00000066070.5 ENSMUST00000066070.6 Eif3s12 NM_028659 Q58EU9 Q8K3A1 Q9DBZ5 uc009gai.1 uc009gai.2 uc009gai.3 uc009gai.4 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Identified in a HCV IRES- mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts with ALKBH4, IFIT1 and IFIT2. Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DBZ5-1; Sequence=Displayed; Name=2; IsoId=Q9DBZ5-2; Sequence=VSP_013425; Belongs to the eIF-3 subunit K family. formation of cytoplasmic translation initiation complex cytoplasmic translational initiation RNA binding translation initiation factor activity nucleus cytoplasm cytosol eukaryotic translation initiation factor 3 complex translation translational initiation regulation of translational initiation eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex ribosome binding uc009gai.1 uc009gai.2 uc009gai.3 uc009gai.4 
ENSMUST00000066087.5 4930563E22Rik ENSMUST00000066087.5 RIKEN cDNA 4930563E22 gene (from RefSeq NM_001163728.1) CQ100_MOUSE ENSMUST00000066087.1 ENSMUST00000066087.2 ENSMUST00000066087.3 ENSMUST00000066087.4 NM_001163728 Q3V1L1 Q8BGJ3 uc011xyh.1 uc011xyh.2 uc011xyh.3 uc011xyh.4 molecular_function cellular_component biological_process uc011xyh.1 uc011xyh.2 uc011xyh.3 uc011xyh.4 
ENSMUST00000066091.14 Smad1 ENSMUST00000066091.14 SMAD family member 1 (from RefSeq NM_008539.4) ENSMUST00000066091.1 ENSMUST00000066091.10 ENSMUST00000066091.11 ENSMUST00000066091.12 ENSMUST00000066091.13 ENSMUST00000066091.2 ENSMUST00000066091.3 ENSMUST00000066091.4 ENSMUST00000066091.5 ENSMUST00000066091.6 ENSMUST00000066091.7 ENSMUST00000066091.8 ENSMUST00000066091.9 Madh1 Madr1 NM_008539 P70340 P70442 Q6GT95 Q9CYK6 SMAD1_MOUSE uc009mip.1 uc009mip.2 uc009mip.3 uc009mip.4 uc009mip.5 Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:11566864, PubMed:15329343, PubMed:21420501, PubMed:35594155). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7- mediated nuclear import (PubMed:34995814). Found in a complex with SMAD4 and YY1. Interacts with HGS, NANOG and ZCCHC12 (PubMed:11094085, PubMed:18160706). Upon C-terminus phosphorylation: forms trimers with another SMAD1 and the co-SMAD SMAD4 (By similarity). Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2, USP15 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with SKOR1. Interacts (via MH2 domain) with LEMD3. Binding to LEMD3 results in at least a partial reduction of receptor-mediated phosphorylation. Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome. Found in a macromolecular complex with FAM83G. Interacts (via MH2 domain) with FAM83G (via MH2 domain); in a SMAD4-independent manner. Interacts with ZC3H3 (PubMed:16115198). Interacts with TMEM119 (PubMed:21239498). Interacts (via MH1 and MH2 domains) with ZNF8 (PubMed:12370310). Interacts with RANBP3L; the interaction increases when SMAD1 is not phosphorylated and mediates SMAD1 nuclear export (PubMed:25755279). Interacts with EGR1; this interaction inhibits SMAD1 dephosphorylation (PubMed:35594155). Interacts with SMAD6 (By similarity). Interacts with YAP1 (By similarity). P70340; Q62073: Map3k7; NbExp=3; IntAct=EBI-6992047, EBI-1775345; Cytoplasm Nucleus Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane (By similarity). Exported from the nucleus to the cytoplasm when dephosphorylated PubMed:25755279. Ubiquitous. Ubiquitously expressed during embryogenesis. Expression starts in some seminiferous tubules at 2 weeks of age. After mid-puberty a stage-specific expression is established. During the cycling of the seminiferous epithelium, expression initiates in the pachytene spermatocytes of stage V seminiferous tubules, peaks at stage X, then decreases as pachytene spermatocytes differentiate into secondary spermatocytes and then round spermatids. The MH2 domain mediates phosphorylation-dependent trimerization through L3 loop binding of phosphoserines in the adjacent subunit. Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor kinase activates SMAD1 by promoting dissociation from the receptor and trimerization with SMAD4. Phosphorylation by ERK2 MAP kinase in response to EGF or HGF prevents SMAD1 nuclear accumulation and transcriptional activity in response to BMP (By similarity). Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (PubMed:25755279). Dephosphorylation is inhibited by association with EGR1 (PubMed:35594155). Phosphorylation by CDK8/9 creates binding sites for YAP1, and subsequent phosphorylation by GSK3 switches off YAP1 binding and adds binding sites for SMURF1 (By similarity). Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes. Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (By similarity). Phospho- SMAD1 is ubiquitinated by CHIP leading to disruption of the SMAD1-SMAD4 complex (By similarity). SMAD1 deletion results in early embryonic lethality due to failure of the allantois to fuse to the chorion (PubMed:11566864). Chondrocyte-specific conditional knockout show a delay in calvarial bone mineralization and reduction of postnatal bone formation (PubMed:21420501). Belongs to the dwarfin/SMAD family. MAPK cascade RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ureteric bud development mesodermal cell fate commitment osteoblast fate commitment DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nuclear inner membrane transcription factor complex cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein phosphorylation inflammatory response transforming growth factor beta receptor signaling pathway SMAD protein complex assembly gamete generation negative regulation of cell proliferation embryonic pattern specification positive regulation of gene expression DEAD/H-box RNA helicase binding protein kinase binding BMP signaling pathway midbrain development hindbrain development macromolecular complex response to drug homeostatic process identical protein binding protein homodimerization activity sequence-specific DNA binding positive regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding cartilage development cardiac muscle cell proliferation bone development SMAD protein signal transduction positive regulation of cartilage development co-SMAD binding I-SMAD binding primary miRNA binding cellular response to organic cyclic compound cellular response to BMP stimulus positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of sprouting angiogenesis uc009mip.1 uc009mip.2 uc009mip.3 uc009mip.4 uc009mip.5 
ENSMUST00000066116.8 Fate1 ENSMUST00000066116.8 fetal and adult testis expressed 1 (from RefSeq NR_003243.2) ENSMUST00000066116.1 ENSMUST00000066116.2 ENSMUST00000066116.3 ENSMUST00000066116.4 ENSMUST00000066116.5 ENSMUST00000066116.6 ENSMUST00000066116.7 FATE1_MOUSE Fate NR_003243 Q14BM4 Q8CEK7 uc009tkj.1 uc009tkj.2 uc009tkj.3 uc009tkj.4 uc009tkj.5 Involved in the regulation of endoplasmic reticulum (ER)- mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling. Interacts with BIK and RNF183. Interacts with IMMT/MIC60and EMD. Mitochondrion Mitochondrion outer membrane Endoplasmic reticulum membrane ; Single- pass membrane protein ; Cytoplasmic side Note=Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER. The human, porcine and bovine orthologs have a longer N- terminal part. mitochondrion mitochondrial outer membrane endoplasmic reticulum endoplasmic reticulum membrane apoptotic process membrane integral component of membrane ubiquitin protein ligase binding regulation of apoptotic process negative regulation of apoptotic process ER-mitochondrion membrane contact site negative regulation of mitochondrial calcium ion concentration uc009tkj.1 uc009tkj.2 uc009tkj.3 uc009tkj.4 uc009tkj.5 
ENSMUST00000066134.6 Rpia ENSMUST00000066134.6 ribose 5-phosphate isomerase A (from RefSeq NM_009075.2) ENSMUST00000066134.1 ENSMUST00000066134.2 ENSMUST00000066134.3 ENSMUST00000066134.4 ENSMUST00000066134.5 NM_009075 P47968 Q3UVI8 RPIA_MOUSE Rpi uc009cfy.1 uc009cfy.2 uc009cfy.3 Reaction=aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate; Xref=Rhea:RHEA:14657, ChEBI:CHEBI:58121, ChEBI:CHEBI:58273; EC=5.3.1.6; Evidence=; Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. Widely expressed, with highest levels in testis. Belongs to the ribose 5-phosphate isomerase family. Sequence=AAC42060.1; Type=Erroneous initiation; Evidence=; Sequence=BAE23281.1; Type=Erroneous initiation; Evidence=; ribose-5-phosphate isomerase activity D-ribose metabolic process pentose-phosphate shunt pentose-phosphate shunt, non-oxidative branch isomerase activity ribose phosphate metabolic process carbohydrate binding identical protein binding intracellular membrane-bounded organelle monosaccharide binding uc009cfy.1 uc009cfy.2 uc009cfy.3 
ENSMUST00000066140.13 Pcdhgc4 ENSMUST00000066140.13 protocadherin gamma subfamily C, 4 (from RefSeq NM_033582.2) ENSMUST00000066140.1 ENSMUST00000066140.10 ENSMUST00000066140.11 ENSMUST00000066140.12 ENSMUST00000066140.2 ENSMUST00000066140.3 ENSMUST00000066140.4 ENSMUST00000066140.5 ENSMUST00000066140.6 ENSMUST00000066140.7 ENSMUST00000066140.8 ENSMUST00000066140.9 NM_033582 Pcdhgc4 Q91XX0 Q91XX0_MOUSE uc008erf.1 uc008erf.2 uc008erf.3 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane synapse organization uc008erf.1 uc008erf.2 uc008erf.3 
ENSMUST00000066148.12 Tbcel ENSMUST00000066148.12 tubulin folding cofactor E-like, transcript variant 2 (from RefSeq NM_173038.5) B9EID8 ENSMUST00000066148.1 ENSMUST00000066148.10 ENSMUST00000066148.11 ENSMUST00000066148.2 ENSMUST00000066148.3 ENSMUST00000066148.4 ENSMUST00000066148.5 ENSMUST00000066148.6 ENSMUST00000066148.7 ENSMUST00000066148.8 ENSMUST00000066148.9 Lrrc35 NM_173038 Q8C5W3 Q8C7A5 TBCEL_MOUSE uc009pay.1 uc009pay.2 uc009pay.3 Acts as a regulator of tubulin stability. Cytoplasm, cytoskeleton Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C5W3-1; Sequence=Displayed; Name=2; IsoId=Q8C5W3-2; Sequence=VSP_019253; microtubule cytoskeleton organization cytoplasm cytoskeleton tubulin complex assembly post-chaperonin tubulin folding pathway alpha-tubulin binding uc009pay.1 uc009pay.2 uc009pay.3 
ENSMUST00000066149.9 Pcdhga8 ENSMUST00000066149.9 protocadherin gamma subfamily A, 8 (from RefSeq NM_033591.3) ENSMUST00000066149.1 ENSMUST00000066149.2 ENSMUST00000066149.3 ENSMUST00000066149.4 ENSMUST00000066149.5 ENSMUST00000066149.6 ENSMUST00000066149.7 ENSMUST00000066149.8 NM_033591 Pcdhga8 Q91XY0 Q91XY0_MOUSE uc008eqv.1 uc008eqv.2 uc008eqv.3 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules biological_process membrane integral component of membrane metal ion binding uc008eqv.1 uc008eqv.2 uc008eqv.3 
ENSMUST00000066157.2 Gm9913 ENSMUST00000066157.2 Gm9913 (from geneSymbol) ENSMUST00000066157.1 LF202442 uc290aco.1 uc290aco.2 uc290aco.1 uc290aco.2 
ENSMUST00000066160.3 Chek2 ENSMUST00000066160.3 checkpoint kinase 2, transcript variant 6 (from RefSeq NR_189323.1) CHK2_MOUSE Chk2 ENSMUST00000066160.1 ENSMUST00000066160.2 NR_189323 Q9Z265 Rad53 uc008yrw.1 uc008yrw.2 uc008yrw.3 Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK- cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Activated through phosphorylation at Thr-68 by ATM in response to DNA double-strand breaks. Activation is modulated by several mediators including MDC1 and TP53BP1. Induces homodimerization with exchange of the T-loop/activation segment between protomers and transphosphorylation of the protomers. The autophosphorylated kinase dimer is fully active. Negatively regulated by PPM1D through dephosphorylation of Thr-68 (By similarity). Homodimer. Homodimerization is part of the activation process but the dimer may dissociate following activation. Interacts with PML. Interacts with TP53. Interacts with RB1; phosphorylates RB1. Interacts with BRCA1. Interacts (phosphorylated at Thr-68) with MDC1; requires ATM-mediated phosphorylation of CHEK2. Interacts with TP53BP1; modulates CHEK2 phosphorylation at Thr-68 in response to ionizing radiation. Interacts with CDC25A; phosphorylates CDC25A and mediates its degradation in response to ionizing radiation. Interacts with CUL1; mediates CHEK2 ubiquitination and regulation. Interacts with CDKN2AIP. Interacts (via protein kinase domain) with CCAR2 (via N-terminus). Interacts with SIRT1 (By similarity). Nucleus, PML body Nucleus, nucleoplasm. Note=Recruited into PML bodies together with TP53. Ubiquitously expressed with higher levels in the thymus, spleen and colon (at protein level). Phosphorylated. Phosphorylated at Ser-82 by PLK3 in response to DNA damage, promoting phosphorylation at Thr-77 by ATM and the G2/M transition checkpoint. Phosphorylation at Thr-77 induces homodimerization. Autophosphorylates at Thr-387 and Thr-391 in the T- loop/activation segment upon dimerization to become fully active. DNA damage-induced autophosphorylation at Ser-383 induces CUL1-mediated ubiquitination and regulates the pro-apoptotic function. Phosphorylation at Ser-460 also regulates ubiquitination. Phosphorylated by PLK4 (By similarity). Ubiquitinated. CUL1-mediated ubiquitination regulates the pro- apoptotic function. Ubiquitination may also regulate protein stability. Ubiquitinated by RNF8 via 'Lys-48'-linked ubiquitination (By similarity). No overt morphological phenotype but apoptosis and cell cycle arrest induced by ionizing radiation are abolished. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily. DNA damage checkpoint G2/M transition of mitotic cell cycle nucleotide binding chromosome, telomeric region replicative cell aging positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleoplasm cytoplasm Golgi apparatus DNA repair double-strand break repair regulation of transcription, DNA-templated protein phosphorylation apoptotic process cellular response to DNA damage stimulus DNA damage induced protein phosphorylation DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cell cycle intrinsic apoptotic signaling pathway in response to DNA damage response to gamma radiation kinase activity phosphorylation PML body transferase activity peptidyl-serine phosphorylation protein kinase binding ubiquitin protein ligase binding cellular response to drug regulation of protein catabolic process signal transduction in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator identical protein binding protein homodimerization activity cellular protein catabolic process mitotic DNA damage checkpoint positive regulation of transcription, DNA-templated protein autophosphorylation metal ion binding protein stabilization cell division negative regulation of cell cycle arrest cellular response to gamma radiation signal transduction involved in intra-S DNA damage checkpoint mitotic spindle assembly response to glycoside cellular response to bisphenol A negative regulation of DNA damage checkpoint positive regulation of anoikis uc008yrw.1 uc008yrw.2 uc008yrw.3 
ENSMUST00000066163.3 A930004D18Rik ENSMUST00000066163.3 RIKEN cDNA A930004D18 gene, transcript variant 1 (from RefSeq NR_028376.1) ENSMUST00000066163.1 ENSMUST00000066163.2 NR_028376 uc289thv.1 uc289thv.2 uc289thv.1 uc289thv.2 
ENSMUST00000066166.6 Tll1 ENSMUST00000066166.6 tolloid-like, transcript variant 1 (from RefSeq NM_009390.4) ENSMUST00000066166.1 ENSMUST00000066166.2 ENSMUST00000066166.3 ENSMUST00000066166.4 ENSMUST00000066166.5 G3X9F5 G3X9F5_MOUSE NM_009390 Tll1 uc009lut.1 uc009lut.2 uc009lut.3 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Note=Binds 1 zinc ion per subunit. Lacks conserved residue(s) required for the propagation of feature annotation. metalloendopeptidase activity calcium ion binding proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding uc009lut.1 uc009lut.2 uc009lut.3 
ENSMUST00000066175.10 Abcg5 ENSMUST00000066175.10 ATP binding cassette subfamily G member 5 (from RefSeq NM_031884.2) ABCG5_MOUSE Abcg5 ENSMUST00000066175.1 ENSMUST00000066175.2 ENSMUST00000066175.3 ENSMUST00000066175.4 ENSMUST00000066175.5 ENSMUST00000066175.6 ENSMUST00000066175.7 ENSMUST00000066175.8 ENSMUST00000066175.9 NM_031884 Q540E8 Q99PE8 uc008dsz.1 uc008dsz.2 uc008dsz.3 uc008dsz.4 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily, and functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. Disruption of this gene in mice results in thrombocytopenia, prolonged bleeding times, anemia, leukopenia, infertility, shortened life span and cardiomyopathy. Mice lacking this gene show symptoms of sitosterolemia. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF312713.2, AK149569.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:16352607, PubMed:16867993, PubMed:18402465). Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:12444248, PubMed:14504269, PubMed:14657202, PubMed:19846887, PubMed:25378657). Required for normal sterol homeostasis (PubMed:12444248, PubMed:14657202). The heterodimer with ABCG8 has ATPase activity (PubMed:16352607, PubMed:16867993). Reaction=ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate; Xref=Rhea:RHEA:39051, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39052; Evidence=; Reaction=ATP + H2O + sitosterol(in) = ADP + H(+) + phosphate + sitosterol(out); Xref=Rhea:RHEA:39103, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27693, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39104; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cholesterol transport is inhibited by vanadate and by beryllium fluoride. Heterodimer with ABCG8. Cell membrane ulti-pass membrane protein Apical cell membrane ulti-pass membrane protein Detected in liver and jejunum (PubMed:12444248, PubMed:15040800, PubMed:18402465, PubMed:25378657). Detected on enterocyte villi (at protein level) (PubMed:15040800). Expressed in jejunum, ileum and, at lower level, in the liver (PubMed:11138003, PubMed:11907139, PubMed:11099417, PubMed:12444248, PubMed:25378657). Up-regulated in liver and small intestine by cholesterol feeding (PubMed:11099417). Up-regulated via the oxysterols receptor LXR/retinoic X receptor (LXR/RXR) pathway (PubMed:14657202). Endotoxin (LPS) significantly decreased mRNA levels in the liver but not in the small intestine (PubMed:12777468). The Walker motif (consensus sequence G-X-X-G-X-G-K-[ST]-T) is expected to bind ATP. Within this motif, the conserved Lys is essential for transport activity mediated by the heterodimer with ABCG8. N-glycosylated (PubMed:12208867, PubMed:12444248, PubMed:16867993, PubMed:15040800, PubMed:15054092, PubMed:18402465, PubMed:25378657). N- glycosylation is important for efficient export out of the endoplasmic reticulum (PubMed:15054092). Note=A spontaneous mutation gives raise to thrombocytopenia and cardiomyopathy (trac), with recessive inheritance and fully penetrant phenotype. Mice are small, infertile, and have shortened lifespan. Mice deficient for both Abcg5 and Abcg8 appear healthy and are fertile, but display strongly increased levels of the food-derived plant sterols sitosterol and campesterol in liver and blood plasma (PubMed:12444248, PubMed:14657202, PubMed:25378657). When mice are fed chow containing 0.02% cholesterol, cholesterol levels in blood plasma and in liver are considerably lower than in wild-type (PubMed:12444248, PubMed:14657202). In spite of the increased plasma and liver levels of plant sterols, and the decreased cholesterol levels, the total sterol levels in plasma and liver are closely similar in wild-type and mutant mice (PubMed:14657202). When mice are fed chow containing 2% cholesterol, plasma cholesterol levels remain stable in wild-type, but increase 2.4-fold in mutant mice. In the liver of mice kept on chow containing 2% cholesterol, cholesterol levels increase 3- fold for wild-type mice and 18-fold for mutant mice, resulting in much higher cholesterol levels than in wild-type livers (PubMed:12444248). Dietary cholesterol absorption appears normal in mutant mice, but the absorption of dietary cholestanol, campesterol and sitosterol is increased (PubMed:12444248). At the same time, mutant mice have very low cholesterol levels in bile, suggesting that the increased hepatic cholesterol levels are due to impaired cholesterol secretion into bile (PubMed:12444248). Likewise, the levels of the food-derived plant sterols stigmasterol, sitosterol, campesterol and brassicasterol are strongly decreased in bile from mutant mice (PubMed:14657202). In contrast, biliary phospholipid and bile acid levels appear unchanged relative to wild-type (PubMed:12444248). The blood plasma of mice with liver-specific or intestine-specific disruption of Abcg5 and Abcg8 has nearly normal levels of cholesterol, and mildly increased levels of sitosterol and campesterol (PubMed:25378657). Mice with intestine- specific disruption of Abcg5 and Abcg8 have strongly increased levels of sitosterol and campesterol in enterocytes, similar to that observed for mice with complete gene disruption (PubMed:25378657). In addition, they display strongly increased levels of sitosterol and campesterol in bile (PubMed:25378657). Mice with liver-specific disruption of Abcg5 and Abcg8 have slightly increased levels of campesterol and sitosterol in the liver, and normal, low levels of sitosterol and campesterol in bile (PubMed:25378657). Enterocytes and liver from mice with liver- specific or intestine-specific disruption of Abcg5 and Abcg8 have normal cholesterol levels (PubMed:25378657). Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. nucleotide binding protein binding ATP binding plasma membrane integral component of plasma membrane lipid transport response to nutrient excretion response to ionizing radiation negative regulation of intestinal phytosterol absorption sterol transport membrane integral component of membrane apical plasma membrane ATPase activity intestinal cholesterol absorption cholesterol efflux response to drug ATPase activity, coupled to transmembrane movement of substances cholesterol homeostasis ATP-binding cassette (ABC) transporter complex receptor complex apical part of cell negative regulation of intestinal cholesterol absorption metal ion binding protein heterodimerization activity transmembrane transport uc008dsz.1 uc008dsz.2 uc008dsz.3 uc008dsz.4 
ENSMUST00000066187.6 Nhlh2 ENSMUST00000066187.6 nescient helix loop helix 2 (from RefSeq NM_178777.3) ENSMUST00000066187.1 ENSMUST00000066187.2 ENSMUST00000066187.3 ENSMUST00000066187.4 ENSMUST00000066187.5 HEN2_MOUSE Hen2 NM_178777 Q64221 Q8BFV7 uc008qro.1 uc008qro.2 uc008qro.3 Transcription factor which binds the E box motif 5'- CA[TC][AG]TG-3' (PubMed:15470499, PubMed:18356286). Involved in regulating energy expenditure, body mass, voluntary physical activity, mating behavior and reproductive longevity, acting through the hypothalamic-pituitary-gonadal axis (PubMed:15470499, PubMed:12419415, PubMed:9090387, PubMed:17717072, PubMed:23785158, PubMed:15465527). Acts as a transcriptional activator of target genes, including Ndn, Pcsk1, Mc4r (PubMed:15470499, PubMed:18356286, PubMed:21664420). Is also a transcriptional activator of KISS1 (By similarity). May act centrally to regulate function of both white and brown adipose tissue (PubMed:20808804, PubMed:19436734). Together with NHLH1, required to maintain migration and survival of cells in the anterior extramural migration stream (aes), which forms the precerebellar nuclei (PubMed:17573818). Also, in concert with Nhlh1, may determine fate of gonadotropin releasing hormone-1 (GnRH-1) neurons (PubMed:15470499). Homodimer. Interacts and may form heterodimers with STAT3. Q64221; Q923E4: Sirt1; NbExp=2; IntAct=EBI-5378529, EBI-1802585; Nucleus Expressed in developing neurons (PubMed:1633105). Transiently expressed in the cerebellum during postnatal development, exclusively in the premigratory zone of the external granule layer where postmitotic neurons undergo initial stages of neuronal differentiation (PubMed:9011755). Expression is not detected in mature neurons (PubMed:9011755). Expressed in the anterior lobe of the adult pituitary (PubMed:9090387). Expressed in embryos at 10.5-13 days post coitus (dpc), including developing ventral hypothalamus, Rathke's pouch and subventricular layers of the developing diencephalon (PubMed:1633105, PubMed:9090387). Expressed in the vomeronasal organ, olfactory epithelium, and vomeronasal nerve fibers at 14.5 to 16.5 dpc (PubMed:15470499). Expressed in various areas of the developing hypothalamus at 18.5 dpc, including the septal areas, the diagonal band of Broca (DBB), within the organum vasculosum lateralis terminalis (OVLT) region, in the paraventricular nucleus (PVN), in lateral areas of the hypothalamus (LH), in the arcuate nucleus (ARC), and in the dorsomedial hypothalamic nucleus (DMH) (PubMed:15470499). Also expressed in the developing pons from 14.5 dpc onwards, including the pontine and reticulotegmental nuclei (PubMed:17573818). Disruption of the hypothalamic-pituitary axis in both genders, but female pubertal development is influenced by the presence or absence of male mice (PubMed:9090387, PubMed:17717072). Altered female sexual behavior and reproductive longevity, with fewer pregnancies over a shorter period, abnormal estrous cycles and reduced ovulation with aging (PubMed:15465527). Reduction in neuroendocrine gonadotropin releasing hormone-1 (GnRH-1) cell number and altered location of these cells, and morphological and functional abnormalities of the adenohypophysis (PubMed:17717072, PubMed:15470499). Ndn expression almost abolished at the level of the optic chiasma in the hypothalamus (PubMed:15470499). Hypothalamic Pcsk1 expression does not respond to signals of energy availability (PubMed:18356286). Progressive adult-onset obesity, preceded by reduced physical activity (PubMed:9090387, PubMed:12419415). Significant reduction in the innervation and vascularization of white adipose tissue and accumulation of preadipocyte/macrophage-like cells, prior to onset of obesity (PubMed:19436734). Defective torpor response and altered serum leptin levels, body temperature and adipose inflammation (PubMed:20808804). Conditional knockout in GnRH neurons but not in pro- opiomelanocortin (POMC) neurons reduces POMC neuron number and increases visceral fat mass (PubMed:23785158). Double knockout of Nhlh1 and Nhlh2 genes causes neonatal lethality, complete absence of GnRH-1 neurons in the posterior parts of the brain at 18.5 days post coitus (dpc) and aberrant morphology of the remaining GnRH-1 neurons in the anterior parts of the brain (PubMed:15470499). Double knockout of Nhlh1 and Nhlh2 genes causes absence of pontine nuclei, which belong to the precerebellar nuclei and are located either side of the midline of the ventral rhombencephalon (PubMed:17573818). Has been reported to be expressed in Rathke's pouch and the developing pituitary gland (PubMed:9090387). However, a later report found no expression in these tissues and speculated that earlier results may represent cross-hybridization with the very similar Nhlh1 gene (PubMed:15470499). RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein binding nucleus regulation of transcription from RNA polymerase II promoter multicellular organism development mating behavior cell differentiation ovulation cycle positive regulation of transcription from RNA polymerase II promoter protein dimerization activity uc008qro.1 uc008qro.2 uc008qro.3 
ENSMUST00000066193.5 Gykl1 ENSMUST00000066193.5 glycerol kinase-like 1 (from RefSeq NM_010293.3) ENSMUST00000066193.1 ENSMUST00000066193.2 ENSMUST00000066193.3 ENSMUST00000066193.4 Gk-rs1 Gykl1 NM_010293 Q8C635 Q8C635_MOUSE uc008exl.1 uc008exl.2 uc008exl.3 uc008exl.4 uc008exl.5 Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. Cytoplasm Belongs to the FGGY kinase family. glycerol kinase activity mitochondrion carbohydrate metabolic process glycerol metabolic process glycerol-3-phosphate metabolic process triglyceride metabolic process membrane integral component of membrane kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor glycerol-3-phosphate biosynthetic process uc008exl.1 uc008exl.2 uc008exl.3 uc008exl.4 uc008exl.5 
ENSMUST00000066196.2 Gm9915 ENSMUST00000066196.2 Gm9915 (from geneSymbol) AK048997 ENSMUST00000066196.1 uc287hqq.1 uc287hqq.2 uc287hqq.1 uc287hqq.2 
ENSMUST00000066197.7 Asic2 ENSMUST00000066197.7 acid-sensing ion channel 2, transcript variant MDEG1 (from RefSeq NM_001034013.2) ASIC2_MOUSE Accn1 Bnac1 ENSMUST00000066197.1 ENSMUST00000066197.2 ENSMUST00000066197.3 ENSMUST00000066197.4 ENSMUST00000066197.5 ENSMUST00000066197.6 NM_001034013 Q5SUU2 Q61203 Q925H0 uc007kmm.1 uc007kmm.2 uc007kmm.3 uc007kmm.4 Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with PRKCABP and ASIC3 (By similarity). Interacts with STOM; this regulates channel activity (PubMed:15471860, PubMed:22850675). Heterotrimer of Asic1a-Asic2a interacts with the snake venom mambalgin-1, mambalgin-2 and mambalgin-3 (By similarity). Heterotrimer of Asic1a-Asic2b interacts with the snake venom mambalgin- 1 and mambalgin-2 (By similarity). Cell membrane ulti-pass membrane protein Note=Localized at the plasma membrane, in the soma and punctated peripheral processes of neurons. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=BNaC1-alpha , Asic2a; IsoId=Q925H0-1; Sequence=Displayed; Name=2; Synonyms=Mdeg2 , Asic2b; IsoId=Q925H0-2; Sequence=VSP_015592, VSP_015593; Expressed by sensory neurons. Expressed by nociceptive sensory neurons, spiral ganglion (SG) neurons and the retina (at protein level). Isoform 1 and isoform 2 are expressed in outer nuclear layer of retina (photoreceptors) and to a lower extent in distal and proximal inner nuclear layer. Expression changes dramatically during cochlear development. Expression is detected at 11.5 dpc in otocyst and increases in the SG neurons after 18.5 dpc. Also detected in the lumen side of all cells forming the vestibular cavity and at the top of the macula of saccule and utricle. Before birth expressed by epithelial cells facing the endolymphatic space. Post-natally expressed by cells in the apical turn of the cochlea, while expression on the lumen side of the membranous labyrinth decreases. Expression shifts gradually toward the top of supporting cells and the spiral limbus. Also expressed by vestibular ganglion neurons. Restricted to the SG neurons in the mature cochlea (at protein level). Expression in a subset of neurons may be regulated by neurotrophins. Mice display altered rod phototransduction and neurotransmission, associated with increased light-induced retina damages. Regulated by Zn(2+). Inhibited by anti-inflammatory drugs like salicylic acid (By similarity). Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback ion channel activity voltage-gated sodium channel activity cation channel activity sodium channel activity protein binding plasma membrane integral component of plasma membrane ion transport cation transport sodium ion transport phototransduction sensory perception of sound response to mechanical stimulus response to acidic pH ligand-gated sodium channel activity membrane integral component of membrane regulation of vasoconstriction ion gated channel activity ion transmembrane transport regulation of ion transmembrane transport protein localization to synapse cellular response to drug sodium ion transmembrane transport regulation of membrane potential neuron projection neuronal cell body negative regulation of apoptotic process dendritic spine synapse sensory perception of sour taste detection of mechanical stimulus involved in sensory perception positive regulation of synapse assembly cellular response to acidic pH cation transmembrane transport positive regulation of cation channel activity uc007kmm.1 uc007kmm.2 uc007kmm.3 uc007kmm.4 
ENSMUST00000066207.4 Mepe ENSMUST00000066207.4 matrix extracellular phosphoglycoprotein with ASARM motif (bone) (from RefSeq NM_053172.2) D6C6N6 ENSMUST00000066207.1 ENSMUST00000066207.2 ENSMUST00000066207.3 MEPE_MOUSE Mepe NM_053172 Q3TYZ5 Q8K4L6 Q924I1 uc008ykh.1 uc008ykh.2 uc008ykh.3 Regulates renal phosphate and uric acid excretion (PubMed:26051469). Regulates bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:11414762, PubMed:12421822, PubMed:15843468, PubMed:22766095). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (PubMed:26927967). Increases dental pulp stem cell proliferation (By similarity). Interacts (via ASARM motif) with PHEX; the interaction is zinc-dependent. Secreted, extracellular space, extracellular matrix creted Expressed in osteocytes (at protein level) (PubMed:12421822, PubMed:15221418). Expressed by chondrocytes, specifically in the hypertrophic zone of the bone growth plate (at protein level) (PubMed:22766095). Expressed in osteoblasts in bone (at protein level) (PubMed:11414762, PubMed:15221418, PubMed:18597632). Expressed by osteoblasts within the metaphysis (at protein level) (PubMed:15221418, PubMed:22766095). Expressed at low levels in white fat, brown fat, testes, brain and aorta (PubMed:12421822). Expressed in the craniofacial complex (at protein level) (PubMed:26927967). Expressed in odontoblasts, ameloblasts and in predentin during tooth development (at protein level) (PubMed:22042093). Expressed in the kidney (at protein level) (PubMed:26051469). Expressed in osteocytes in mandibular condylar cartilage and tibial cartilage (at protein level) (PubMed:26428891). Expressed in salivary glands (PubMed:15329369). Detected at 16 days post coitum (dpc) in both epithelial and mesenchymal components of the tooth organ (PubMed:26927967). Also detected at 16 dpc and 18 dpc in mandibular bone osteocytes (PubMed:26428891). Detected at 15 dpc in the bone collar (PubMed:26428891). Detected at 13 dpc in the cartilage matrix (PubMed:26428891). Detected at postnatal day 3 in odontoblasts and ameloblasts (PubMed:22042093). At postnatal day 5, expression is decreased in dental papilla cells, but increased in the predentin (PubMed:22042093). By postnatal day 9, is only detected in the predentin (PubMed:22042093). Detected at postnatal day 2 in osteoblasts, the calcified cartilage cores in primary metaphyseal bone and in osterocytes embedded in cortical bone matrix (PubMed:15221418). At postnatal day 84 expression is detected in the osteocytes of cortical and trabecular bone (PubMed:15221418). Induced by ascorbate and beta-glycerophosphate (PubMed:11414762, PubMed:12421822). Induced expression during bone fracture healing, with low levels of expression being detected in fibroblast-like cells at 6 days post-fracture, and increased expression at 10 days post-fracture in late hypertrophic chondrocytes. At 14 days post-fracture, expression is detected in osteocytes, osteoblasts, and hypertrophic chondrocytes. By 28 days post-fracture, expression was highest in osteocytes and lower in osteoblasts (PubMed:15221418). Down- regulated by 1-alpha-25-dihydroxyvitamin D3 (calcitriol) (PubMed:11414762). The acidic serine aspartate-rich MEPE-associated (ASARM) motif is sufficient when phosphorylated to inhibit bone mineralization by osteoblasts and cartilage mineralization by chondrocytes by binding hydroxyapatite crystals during the mineralization stage (PubMed:15843468, PubMed:22766095, PubMed:26051469). It can also inhibit dentin mineralization (By similarity). The dentonin region is sufficient to promote dental pulp stem cell proliferation. It can also stimulate bone formation, osteoblast differentiation, and activate integrin signaling pathways. Phosphorylated on serine residues in the ASARM motif; the phosphorylation is important for the inhibition of bone mineralization. Cleaved by CTSB/cathepsin B; the cleavage is blocked by metalloprotease PHEX. Mutant mice exhibit increased cancellous bone mass and no loss of trabecular bone characteristics (PubMed:12421822, PubMed:26051469). They also exhibit decreased biomechanical strength in their bones and increased skeletal mineralization (PubMed:15843468). In craniofacial complex development, mutant mice also exhibit hypermineralization in predentin, dentin and enamel of teeth and decreased expression of AMBN, ENAM, IBSP, DMP1, DSPP and SPP1 (PubMed:26927967). Mutant mice also exhibit hyperphostatemia and increased expression of SLC34A1/NPT2a, SLC34A3/NPT2c and VEGF in the kidney (PubMed:26051469). Hyperuricemia and reduced fractional excretion of uric acid was also exhibited (PubMed:26051469). As mutant mice age, bone mineral density and content is increased (PubMed:26051469). It has been proposed that MEPE is cleaved and generate 2 peptides dentonin and ASARM peptide. Belongs to the PF07175/osteoregulin family. Sequence=AAI19163.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAK70342.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=ACS37545.1; Type=Erroneous gene model prediction; Evidence=; skeletal system development extracellular region negative regulation of bone mineralization extracellular matrix biomineral tissue development extracellular matrix protein binding uc008ykh.1 uc008ykh.2 uc008ykh.3 
ENSMUST00000066208.13 Aldh7a1 ENSMUST00000066208.13 aldehyde dehydrogenase family 7, member A1, transcript variant 1 (from RefSeq NM_138600.4) AL7A1_MOUSE Ald7a1 Aldh7a1 ENSMUST00000066208.1 ENSMUST00000066208.10 ENSMUST00000066208.11 ENSMUST00000066208.12 ENSMUST00000066208.2 ENSMUST00000066208.3 ENSMUST00000066208.4 ENSMUST00000066208.5 ENSMUST00000066208.6 ENSMUST00000066208.7 ENSMUST00000066208.8 ENSMUST00000066208.9 NM_138600 Q3TFC7 Q3TVH7 Q3UKT6 Q9DBF1 uc008eyn.1 uc008eyn.2 uc008eyn.3 uc008eyn.4 Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. Reaction=H2O + NAD(+) + nonanal = 2 H(+) + NADH + nonanoate; Xref=Rhea:RHEA:69759, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32361, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:84268; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69760; Evidence=; Reaction=(S)-2-amino-6-oxohexanoate + H2O + NAD(+) = 2 H(+) + L-2- aminoadipate + NADH; Xref=Rhea:RHEA:12308, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58321, ChEBI:CHEBI:58672; EC=1.2.1.31; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12309; Evidence=; Reaction=betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH; Xref=Rhea:RHEA:15305, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15710, ChEBI:CHEBI:17750, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15306; Evidence=; Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16186; Evidence=; Reaction=H2O + hexanal + NAD(+) = 2 H(+) + hexanoate + NADH; Xref=Rhea:RHEA:67276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:88528; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67277; Evidence=; Reaction=H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate; Xref=Rhea:RHEA:44100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:25646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44101; Evidence=; Reaction=(E)-non-2-enal + H2O + NAD(+) = (E)-non-2-enoate + 2 H(+) + NADH; Xref=Rhea:RHEA:69767, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:142592, ChEBI:CHEBI:143908; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69768; Evidence=; Reaction=(E)-4-hydroxynon-2-enal + H2O + NAD(+) = (E)-4-hydroxynon-2- enoate + 2 H(+) + NADH; Xref=Rhea:RHEA:67248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58968, ChEBI:CHEBI:142920; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67249; Evidence=; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. Homotetramer. [Isoform 1]: Cytoplasm, cytosol Nucleus [Isoform 2]: Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=mALDH7A1_v2 ; IsoId=Q9DBF1-1; Sequence=Displayed; Name=2; Synonyms=mALDH7A1_v1 ; IsoId=Q9DBF1-2; Sequence=VSP_038989; Present in liver, kidney, brain and pancreas, and at lower levels in jejunum, duodenum, stomach and testes (at protein level). Belongs to the aldehyde dehydrogenase family. Sequence=AAH12407.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE26715.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; aldehyde dehydrogenase (NAD) activity L-aminoadipate-semialdehyde dehydrogenase activity nucleus cytoplasm mitochondrion cytosol betaine-aldehyde dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor glycine betaine biosynthetic process from choline glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity oxidation-reduction process uc008eyn.1 uc008eyn.2 uc008eyn.3 uc008eyn.4 
ENSMUST00000066211.5 Gper1 ENSMUST00000066211.5 G protein-coupled estrogen receptor 1 (from RefSeq NM_029771.3) B2RRW0 Cmkrl2 ENSMUST00000066211.1 ENSMUST00000066211.2 ENSMUST00000066211.3 ENSMUST00000066211.4 GPER1_MOUSE Gper Gpr30 NM_029771 Q8BMP4 Q9D392 uc009agr.1 uc009agr.2 uc009agr.3 uc009agr.4 G-protein coupled estrogen receptor that binds to 17-beta- estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells. Interacts with RAMP3. Interacts with KRT7 and KRT8. Interacts with EGFR; the interaction increases after agonist-induced stimulation in cancer-associated fibroblasts (CAF). Interacts with EGFR and ESR1. Interacts (via C-terminus tail motif) with DLG4 (via N-terminus tandem pair of PDZ domains); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner (By similarity). Homodimer (Probable). Heterodimer; heterodimerizes with other G-protein-coupled receptor (GPCRs) like CRHR1, HTR1A and PAQR8. Nucleus Cytoplasm. Cytoplasm, perinuclear region Cytoplasm, cytoskeleton Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Cell projection, dendrite Cytoplasmic vesicle membrane ; Multi-pass membrane protein Early endosome Recycling endosome Golgi apparatus, trans-Golgi network Cell projection, dendritic spine membrane ; Multi-pass membrane protein Cell projection, axon Postsynaptic density Mitochondrion membrane ; Multi-pass membrane protein Note=Colocalized with BSN to the active zone of presynaptic density. Colocalized with DLG4/PSD95 and neurabin-2 PPP1R9B in neuronal synaptosomes. Endocytosed in an agonist- and arrestin-independent manner. Colocalized with RAMP3 and clathrin-coated pits at the plasma membrane. Colocalized with transferrin receptor at the plasma membrane and perinuclear region. Accumulated and colocalized with RAB11 proteins in recycling endosomes and trans-Golgi network (TGN), but does neither recycle back to the cell surface nor traffics to late endosome or lysosome. Colocalized with calnexin in the endoplasmic reticulum. Traffics to intracellular sites via cytokeratin intermediate filaments like KRT7 and KRT8 after constitutive endocytosis in epithelial cells. Colocalized with EGFR in the nucleus of agonist-induced cancer- associated fibroblasts (CAF) (By similarity). Expressed in brain, heart, spleen, preadipocytes, mature adipocytes and primary hippocampal neurons. Expressed in neurons of the hippocampus, hypothalamic paraventricular nucleus (PVH), supraoptic nucleus (SON) and the median eminence. Expressed in the nucleus ambiguous (at protein level). Expressed in brain, pituitary gland, adrenal medulla, renal pelvis, ovary, endothelial cells, visceral fat tissues and islets of Langerhans. Up-regulated during adipogenesis. Ubiquitinated; ubiquitination occurs at the plasma membrane and leads to proteasome-mediated degradation. N-glycosylated. Strong variations in phenotypes, probably depending on the distinct targeting strategies, genetic background and experimental conditions used in the different experiments. According to PubMed:18063692, mice are viable and fertile and do not display any gross physical, immunological, reproductive and neurological abnormalities, but show 17-beta-estradiol (E2)-induced alleviated thymic atrophy. According to PubMed:20734455, male mice display increased body size, femur length, bone mass and cell proliferative activity within the growth plate. According to PubMed:18845638, female mice, but not male, show reduced body weight and skeletal growth, hyperglycemia, impaired glucose tolerance with reduced glucose- stimulated insulin release and increased blood pressure. According to PubMed:19179659 mice show increased body weight, visceral adiposity, vascular tone and blood pressure. No visible phenotype according to PubMed:18799753. Belongs to the G-protein coupled receptor 1 family. Golgi membrane positive regulation of protein phosphorylation positive regulation of neurotransmitter secretion immune system process negative regulation of leukocyte activation chromatin binding steroid hormone receptor activity G-protein coupled receptor activity steroid binding nucleus nuclear envelope cytoplasm mitochondrion endosome early endosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus trans-Golgi network cytoskeleton plasma membrane apoptotic process inflammatory response cell cycle signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration nervous system development drug binding positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression negative regulation of cell cycle process positive regulation of phosphatidylinositol 3-kinase signaling postsynaptic density membrane integral component of membrane neuronal action potential cell junction cell differentiation apoptotic chromosome condensation nuclear fragmentation involved in apoptotic nuclear change estrogen receptor activity positive regulation of cell migration axon dendrite intracellular steroid hormone receptor signaling pathway cytoplasmic vesicle membrane cytoplasmic vesicle mitochondrial membrane positive regulation of insulin secretion dendritic spine membrane positive regulation of inositol trisphosphate biosynthetic process hormone binding presynaptic membrane cell projection positive regulation of apoptotic process dendritic shaft positive regulation of cysteine-type endopeptidase activity involved in apoptotic process steroid hormone mediated signaling pathway positive regulation of MAPK cascade axon terminus dendritic spine head innate immune response keratin filament synapse postsynaptic membrane negative regulation of fat cell differentiation positive regulation of epidermal growth factor receptor signaling pathway positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm presynaptic active zone negative regulation of inflammatory response positive regulation of neurogenesis modulation of synaptic transmission negative regulation of DNA metabolic process negative regulation of lipid biosynthetic process positive regulation of release of sequestered calcium ion into cytosol regulation of cytosolic calcium ion concentration negative regulation of protein kinase B signaling recycling endosome negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of uterine smooth muscle contraction negative regulation of cell cycle arrest cellular response to glucose stimulus cellular response to tumor necrosis factor cellular response to peptide hormone stimulus cellular response to mineralocorticoid stimulus cellular response to estradiol stimulus positive regulation of release of cytochrome c from mitochondria positive regulation of protein localization to plasma membrane negative regulation of vascular smooth muscle cell proliferation steroid hormone binding positive regulation of endothelial cell apoptotic process positive regulation of cardiac vascular smooth muscle cell differentiation positive regulation of extrinsic apoptotic signaling pathway uc009agr.1 uc009agr.2 uc009agr.3 uc009agr.4 
ENSMUST00000066257.6 Khdrbs1 ENSMUST00000066257.6 KH domain containing, RNA binding, signal transduction associated 1, transcript variant 1 (from RefSeq NM_011317.4) A2ACH3 B2KG38 ENSMUST00000066257.1 ENSMUST00000066257.2 ENSMUST00000066257.3 ENSMUST00000066257.4 ENSMUST00000066257.5 KHDR1_MOUSE Khdrbs1 NM_011317 Q3U8T3 Q60735 Q60749 Q7M4N5 Q99M33 uc008uyd.1 uc008uyd.2 uc008uyd.3 uc008uyd.4 uc008uyd.5 Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. May not be involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species. RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'- [AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (By similarity). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner. Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (PubMed:12478298, PubMed:22196734, PubMed:24469635). Self-associates to form homooligomers when bound to RNA, oligomerization appears to be limited when binding to proteins (PubMed:9315629). Interacts with KHDRBS3/SLIM-2 and KHDRBS2/SLIM-1; heterooligomer formation of KHDRBS family proteins may modulate RNA substrate specificity (PubMed:10077576, PubMed:24469635). Interacts with RASA1, FYN, GRB2, PLCG1, SRC, RBMY1A1, CBP, PRMT1 (PubMed:7799925, PubMed:7512695, PubMed:10077576, PubMed:10823932, PubMed:12496368, PubMed:12529443). Interacts with PTK6 (via SH3 and SH2 domains). Forms a complex with ILF2, ILF3, YLPM1, RBMX, NCOA5 and PPP1CA. Binds WBP4/FBP21 (via WW domains), FNBP4/FBP30 (via WW domains). Interacts (via Arg/Gly-rich-flanked Pro-rich regions) with FYN (via the SH3 domain). Interacts with APC, HNRNPA1 (By similarity). Interacts with the non-receptor tyrosine kinase SRMS; the interaction leads to phosphorylation of KHDRBS1 (By similarity). Interacts with ZBTB7A; negatively regulates KHDRBS1 splicing activity toward BCL2L1 (By similarity). Q60749; P45481: Crebbp; NbExp=7; IntAct=EBI-519077, EBI-296306; Q60749; P39688: Fyn; NbExp=15; IntAct=EBI-519077, EBI-524514; Q60749; Q60631: Grb2; NbExp=2; IntAct=EBI-519077, EBI-1688; Q60749; Q60749: Khdrbs1; NbExp=2; IntAct=EBI-519077, EBI-519077; Q60749; Q9JIF0: Prmt1; NbExp=2; IntAct=EBI-519077, EBI-519055; Q60749; P10686: Plcg1; Xeno; NbExp=2; IntAct=EBI-519077, EBI-520788; Nucleus Cytoplasm Membrane Note=Predominantly located in the nucleus but also located partially in the cytoplasm. In adult cerebellum expressed in most neuronal cell populations, specifically in cerebellar granule cells of the internal granular layer, ROR(alpha)-positive Purkinje cells, internal granular layer and molecular layer interneurons (at protein level). In the developing cerebellum expression is high at birth and declines over the first 3 weeks. At P7 highly expressed in granule cell precursor cells in the external granular layer and mature granule cells of the internal granule layer. The KH domain is required for binding to RNA. The Pro-rich domains are flanked by Arg/Gly-rich motifs which can be asymmetric dimethylated on arginine residues to give the DMA/Gly-rich regions. Selective methylation on these motifs can modulate protein-protein interactions (By similarity). Tyrosine phosphorylated by several non-receptor tyrosine kinases including LCK, FYN and JAK3. Also tyrosine phosphorylated by the non- receptor tyrosine kinase SRMS in an EGF-dependent manner (By similarity). Phosphorylation by PTK6 negatively regulates its RNA binding ability. Phosphorylation by PTK6 at Tyr-440 dictates the nuclear localization of KHDRBS1. Phosphorylation by MAPK1 at Ser-58, Thr-71 and Thr-84 regulates CD44 alternative splicing by promoting CD44 exon v5 inclusion. Acetylated. Positively correlates with ability to bind RNA (By similarity). Arginine methylation is required for nuclear localization. Inhibits interaction with Src-like SH3 domains, but not interaction with WW domains of WBP4/FBP21 and FNBP4/FBP30 (By similarity). Belongs to the KHDRBS family. negative regulation of transcription from RNA polymerase II promoter regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding SH3/SH2 adaptor activity protein binding nucleus nucleoplasm cytoplasm mRNA processing cell cycle cell surface receptor signaling pathway spermatogenesis poly(A) binding poly(U) RNA binding positive regulation of signal transduction membrane SH3 domain binding protein domain specific binding identical protein binding macromolecular complex binding positive regulation of translational initiation regulation of RNA export from nucleus positive regulation of RNA export from nucleus regulation of mRNA splicing, via spliceosome protein oligomerization Grb2-Sos complex uc008uyd.1 uc008uyd.2 uc008uyd.3 uc008uyd.4 uc008uyd.5 
ENSMUST00000066258.8 Defb40 ENSMUST00000066258.8 defensin beta 40 (from RefSeq NM_183039.4) A0A0R4J0U1 A0A0R4J0U1_MOUSE Defb40 ENSMUST00000066258.1 ENSMUST00000066258.2 ENSMUST00000066258.3 ENSMUST00000066258.4 ENSMUST00000066258.5 ENSMUST00000066258.6 ENSMUST00000066258.7 NM_183039 uc009kzy.1 uc009kzy.2 uc009kzy.3 Secreted extracellular region defense response uc009kzy.1 uc009kzy.2 uc009kzy.3 
ENSMUST00000066264.13 Ech1 ENSMUST00000066264.13 enoyl coenzyme A hydratase 1, peroxisomal (from RefSeq NM_016772.1) ECH1_MOUSE ENSMUST00000066264.1 ENSMUST00000066264.10 ENSMUST00000066264.11 ENSMUST00000066264.12 ENSMUST00000066264.2 ENSMUST00000066264.3 ENSMUST00000066264.4 ENSMUST00000066264.5 ENSMUST00000066264.6 ENSMUST00000066264.7 ENSMUST00000066264.8 ENSMUST00000066264.9 Ech1 NM_016772 O35459 Q5M8P6 uc009gab.1 uc009gab.2 uc009gab.3 Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4- trans-dienoyl-CoA. Reaction=(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA; Xref=Rhea:RHEA:45244, ChEBI:CHEBI:62243, ChEBI:CHEBI:85108; Evidence=; Reaction=(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA = (2E,4E,8Z,11Z,14Z)- eicosapentaenoyl-CoA; Xref=Rhea:RHEA:45224, ChEBI:CHEBI:85090, ChEBI:CHEBI:85091; Evidence=; Lipid metabolism; fatty acid beta-oxidation. Homohexamer. Mitochondrion Peroxisome Belongs to the enoyl-CoA hydratase/isomerase family. catalytic activity mitochondrion peroxisome lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation isomerase activity delta3,5-delta2,4-dienoyl-CoA isomerase activity uc009gab.1 uc009gab.2 uc009gab.3 
ENSMUST00000066272.6 Taf7 ENSMUST00000066272.6 TATA-box binding protein associated factor 7 (from RefSeq NM_175770.4) ENSMUST00000066272.1 ENSMUST00000066272.2 ENSMUST00000066272.3 ENSMUST00000066272.4 ENSMUST00000066272.5 NM_175770 Q9R1C0 TAF7_MOUSE Taf2f uc008eqi.1 uc008eqi.2 uc008eqi.3 The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2. Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta). Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP- associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Part of a TFIID- containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TAF1; the interaction is direct (By similarity). Interacts with TAF1, TAF5, TAF11, TAF12, and TAF13, but not with TAF10 or TBP (PubMed:10438527). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CIITA and TAF1 and inhibits their acetyltransferase activity, and behaving as a repressor of CIITA- and TAF1-regulated promoters (By similarity). Nucleus The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase. Phosphorylated by CIITA. Phosphorylation at Ser-256 by TAF1 in early G1 phase disrupts binding to TAF1 (By similarity). Ubiquitinated by TRIM26; leading to proteasomal degradation. Belongs to the TAF7 family. negative regulation of transcription from RNA polymerase II promoter TFIIH-class transcription factor binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus nucleoplasm transcription factor complex transcription factor TFIID complex cytoplasm Golgi apparatus DNA-templated transcription, initiation regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter negative regulation of protein kinase activity transcription factor binding intracellular estrogen receptor signaling pathway transcription factor TFTC complex histone acetyltransferase binding negative regulation of histone acetylation vitamin D receptor binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter thyroid hormone receptor binding protein heterodimerization activity RNA polymerase II transcriptional preinitiation complex assembly H3K27me3 modified histone binding MLL1 complex uc008eqi.1 uc008eqi.2 uc008eqi.3 
ENSMUST00000066279.11 Sh3bp4 ENSMUST00000066279.11 SH3-domain binding protein 4, transcript variant 1 (from RefSeq NM_133816.4) ENSMUST00000066279.1 ENSMUST00000066279.10 ENSMUST00000066279.2 ENSMUST00000066279.3 ENSMUST00000066279.4 ENSMUST00000066279.5 ENSMUST00000066279.6 ENSMUST00000066279.7 ENSMUST00000066279.8 ENSMUST00000066279.9 NM_133816 Q8BXV5 Q8BY95 Q8C007 Q921I6 SH3B4_MOUSE uc007byv.1 uc007byv.2 uc007byv.3 May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity). Homodimer or homooligomer. Interacts with DNM2, EPS15, clathrin, the adapter protein complex 2/AP-2 and TFRC. Interacts with the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; the interaction is most probably direct, preferentially occurs with their inactive GDP-bound form and is negatively regulated by amino acids (By similarity). Membrane, clathrin-coated pit Cytoplasmic vesicle, clathrin-coated vesicle Nucleus Note=Specifically associated with transferrin receptor- containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus (By similarity). The SH3 domain mediates localization to the clathrin-coated pits and vesicles. The SH3 domain mediates interaction with DNM2 and the cytoplasmic part of TFRC with a lower affinity. The SH3 domain also mediates interaction with RRAGB, RRAGC and is required for the negative regulation of mTORC1 (By similarity). Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2 (By similarity). GDP-dissociation inhibitor activity nucleus cytoplasm clathrin-coated pit endocytosis negative regulation of cell proliferation positive regulation of autophagy membrane Ras GTPase binding clathrin-coated vesicle negative regulation of cell growth cytoplasmic vesicle negative regulation of TOR signaling negative regulation of GTPase activity identical protein binding regulation of catalytic activity protein localization to lysosome cellular response to amino acid stimulus uc007byv.1 uc007byv.2 uc007byv.3 
ENSMUST00000066282.4 Defb37 ENSMUST00000066282.4 defensin beta 37 (from RefSeq NM_181683.3) DFB37_MOUSE ENSMUST00000066282.1 ENSMUST00000066282.2 ENSMUST00000066282.3 NM_181683 Q7TMD2 uc009kzz.1 uc009kzz.2 Has antibacterial activity. Secreted Only expressed in epididymis (corpus and cauda). Belongs to the beta-defensin family. molecular_function cellular_component extracellular region defense response biological_process defense response to bacterium uc009kzz.1 uc009kzz.2 
ENSMUST00000066283.12 Lif ENSMUST00000066283.12 leukemia inhibitory factor, transcript variant 1 (from RefSeq NM_008501.3) ENSMUST00000066283.1 ENSMUST00000066283.10 ENSMUST00000066283.11 ENSMUST00000066283.2 ENSMUST00000066283.3 ENSMUST00000066283.4 ENSMUST00000066283.5 ENSMUST00000066283.6 ENSMUST00000066283.7 ENSMUST00000066283.8 ENSMUST00000066283.9 LIF_MOUSE NM_008501 P09056 uc007hut.1 uc007hut.2 uc007hut.3 LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. Secreted. Belongs to the LIF/OSM family. blood vessel remodeling receptor binding cytokine activity leukemia inhibitory factor receptor binding extracellular region extracellular space cytosol immune response tyrosine phosphorylation of STAT protein embryo implantation growth factor activity positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of gene expression positive regulation of neuron projection development negative regulation of angiogenesis stem cell population maintenance lung development animal organ regeneration positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein positive regulation of MAPK cascade regulation of cell differentiation positive regulation of macrophage differentiation negative regulation of meiotic nuclear division positive regulation of transcription from RNA polymerase II promoter decidualization negative regulation of hormone secretion lung alveolus development muscle organ morphogenesis neuron development astrocyte differentiation positive regulation of astrocyte differentiation leukemia inhibitory factor signaling pathway stem cell differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of corticotropin secretion retina development in camera-type eye maternal process involved in female pregnancy transdifferentiation lung vasculature development lung lobe morphogenesis trophoblast giant cell differentiation spongiotrophoblast differentiation negative regulation of ERK1 and ERK2 cascade positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis regulation of metanephric nephron tubule epithelial cell differentiation positive regulation of protein localization to nucleus positive regulation of histone H3-K27 acetylation regulation of RNA polymerase II regulatory region sequence-specific DNA binding uc007hut.1 uc007hut.2 uc007hut.3 
ENSMUST00000066285.6 Hspa12a ENSMUST00000066285.6 heat shock protein 12A, transcript variant 2 (from RefSeq NM_175199.3) ENSMUST00000066285.1 ENSMUST00000066285.2 ENSMUST00000066285.3 ENSMUST00000066285.4 ENSMUST00000066285.5 HS12A_MOUSE Kiaa0417 NM_175199 Q3UQZ8 Q8CHF6 Q8K0U4 uc008iaw.1 uc008iaw.2 uc008iaw.3 uc008iaw.4 uc008iaw.5 Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. Interacts with SORL1 (via cytosolic C-terminus); this interaction affects SORL1 internalization and subcellular localization. Cytoplasm Nucleus Expressed most strongly in brain, kidney and heart with little or no expression in other tissues (PubMed:12552099). In the brain, expressed in glial cells, including astrocytes (at protein level) (PubMed:30679749). In the aorta, preferentially expressed in lesions (PubMed:12552099). Belongs to the heat shock protein 70 family. Sequence=BAC41423.1; Type=Erroneous initiation; Evidence=; nucleotide binding molecular_function ATP binding nucleus cytoplasm biological_process uc008iaw.1 uc008iaw.2 uc008iaw.3 uc008iaw.4 uc008iaw.5 
ENSMUST00000066295.5 Kcnk3 ENSMUST00000066295.5 potassium channel, subfamily K, member 3 (from RefSeq NM_010608.3) Ctbak ENSMUST00000066295.1 ENSMUST00000066295.2 ENSMUST00000066295.3 ENSMUST00000066295.4 KCNK3_MOUSE NM_010608 O35111 O35163 Task Task1 uc008wvr.1 uc008wvr.2 uc008wvr.3 pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Homodimer. Heterodimer with KCNK1. Cell membrane ; Multi-pass membrane protein Very strong expression in heart, also detected in kidney, brain, skin, testis, lung, skeletal muscle, small intestine and stomach. Not detected in liver, thymus or spleen. Inactivated by barium. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. ion channel activity open rectifier potassium channel activity potassium channel activity plasma membrane integral component of plasma membrane ion transport potassium ion transport brain development protein C-terminus binding membrane integral component of membrane potassium ion leak channel activity stabilization of membrane potential ion transmembrane transport response to drug S100 protein binding negative regulation of cytosolic calcium ion concentration cellular response to zinc ion cellular response to hypoxia potassium ion transmembrane transport cochlea development uc008wvr.1 uc008wvr.2 uc008wvr.3 
ENSMUST00000066308.9 Cfap58 ENSMUST00000066308.9 cilia and flagella associated protein 58 (from RefSeq NM_001163267.1) B2RW38 CFA58_MOUSE Cfap58 ENSMUST00000066308.1 ENSMUST00000066308.2 ENSMUST00000066308.3 ENSMUST00000066308.4 ENSMUST00000066308.5 ENSMUST00000066308.6 ENSMUST00000066308.7 ENSMUST00000066308.8 NM_001163267 uc008hvw.1 uc008hvw.2 uc008hvw.3 Has an essential role in the assembly and organization of the sperm flagellar axoneme (PubMed:32791035). Required for the elongation of the primary cilium and sperm flagellar midpiece via modulation of the Notch signaling pathway (PubMed:31904090). Interacts with ODFP2. Cell projection, cilium Cell projection, cilium, flagellum Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localized to the entire flagellum and predominantly concentrated in the midpiece. Co-localizes with ODFP2 at the centrosome. Predominantly expressed in the testis (PubMed:32791035, PubMed:31904090). Also found at lower levels in ciliated cells and tissues such as neural progenitor cells and oviducts (PubMed:31904090). Male mice are infertile with severely decreased sperm motility and abnormal sperm flagellar morphology. Belongs to the CFAP58 family. molecular_function cilium biological_process cell projection uc008hvw.1 uc008hvw.2 uc008hvw.3 
ENSMUST00000066317.5 Vmn2r43 ENSMUST00000066317.5 vomeronasal 2, receptor 43 (from RefSeq NM_198961.3) EC2-V2R ENSMUST00000066317.1 ENSMUST00000066317.2 ENSMUST00000066317.3 ENSMUST00000066317.4 Gm1961 NM_198961 Q80Z08 Q80Z08_MOUSE Vmn2r43 uc009fcx.1 uc009fcx.2 uc009fcx.3 uc009fcx.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009fcx.1 uc009fcx.2 uc009fcx.3 uc009fcx.4 
ENSMUST00000066319.8 Cimap3 ENSMUST00000066319.8 ciliary microtubule associated protein 3, transcript variant 2 (from RefSeq NM_029604.3) CMAP3_MOUSE D9J0A0 D9J0A1 ENSMUST00000066319.1 ENSMUST00000066319.2 ENSMUST00000066319.3 ENSMUST00000066319.4 ENSMUST00000066319.5 ENSMUST00000066319.6 ENSMUST00000066319.7 NM_029604 Pifo Q810M7 Q9D9W1 uc008qvr.1 uc008qvr.2 uc008qvr.3 During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle- dependent manner. Interacts with proteins involved in ciliary transport, including ARL13B, CETN1, KIF3A, RAB6A, RAB8A, TUBB1 and TUBG1. Interacts with AURKA. [Isoform 1]: Golgi apparatus, Golgi stack. Golgi apparatus, trans-Golgi network. [Isoform 2]: Nucleus. Cytoplasm Cytoplasmic vesicle Note=Accumulates specifically at the basal body and ciliary necklace during the early steps of cilia assembly and disassembly, when structural, functional and regulatory proteins are delivered to cilia. At S phase, accumulates in vesicles and declines during mitosis. In node pit cells, found close to the ciliary membrane along the axoneme. In spermatocytes, localizes to particles along the stabilized microtubules of tails. Event=Alternative promoter usage; Named isoforms=2; Name=1; IsoId=Q9D9W1-1; Sequence=Displayed; Name=2; IsoId=Q9D9W1-2; Sequence=VSP_024558; Expressed in tissues rich in ciliated cells, such as lung, kidney, vas deferens and testis. Both isoforms 1 and 2 are expressed in testis. At 7.75 dpc, expression restricted to the ventral node monociliated pit cells. Not expressed in other tissues at detectable levels until 9.5 dpc. At 10.5 dpc, expressed in motor neurons in the ventral neural tube and in the apical ectodermal ridge of lim buds. protein binding nucleus cytoplasm Golgi apparatus Golgi stack trans-Golgi network Rab GTPase binding kinesin binding protein kinase binding cell projection organization regulation of cell projection organization cytoplasmic vesicle positive regulation of kinase activity ciliary basal body gamma-tubulin binding beta-tubulin binding uc008qvr.1 uc008qvr.2 uc008qvr.3 
ENSMUST00000066328.5 Spinkl ENSMUST00000066328.5 serine protease inhibitor, Kazal type-like (from RefSeq NM_183123.2) ENSMUST00000066328.1 ENSMUST00000066328.2 ENSMUST00000066328.3 ENSMUST00000066328.4 NM_183123 Q8CEK3 SPIKL_MOUSE uc008eut.1 uc008eut.2 uc008eut.3 Does not function as an inhibitor of trypsin, chymotrypsin, subtilisin or elastase. Binds sperm and enhances sperm motility. May act as a decapacitation factor, suppresses BSA-stimulated sperm capacitation and blocks sperm-oocyte interactions in vitro. Secreted Luminal fluid and mucosal folds of the seminal vesicles (at protein level). Not detected in brain, heart, lung, liver, kidney, stomach, small intestine, muscle, skin, thymus, placenta or bladder. First appears at low levels in 3 week old mice. Levels increase rapidly after 4 weeks, highest levels are reached in 8 week old mice. By testosterone. extracellular region extracellular space positive regulation of flagellated sperm motility negative regulation of sperm capacitation uc008eut.1 uc008eut.2 uc008eut.3 
ENSMUST00000066337.13 Alas2 ENSMUST00000066337.13 aminolevulinic acid synthase 2, erythroid, transcript variant 1 (from RefSeq NM_009653.4) ENSMUST00000066337.1 ENSMUST00000066337.10 ENSMUST00000066337.11 ENSMUST00000066337.12 ENSMUST00000066337.2 ENSMUST00000066337.3 ENSMUST00000066337.4 ENSMUST00000066337.5 ENSMUST00000066337.6 ENSMUST00000066337.7 ENSMUST00000066337.8 ENSMUST00000066337.9 HEM0_MOUSE NM_009653 P08680 Q64452 Q9DCN0 uc009uoj.1 uc009uoj.2 uc009uoj.3 Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:3557128, PubMed:8268805). Contributes significantly to heme formation during erythropoiesis (By similarity). Reaction=glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO2 + CoA; Xref=Rhea:RHEA:12921, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:57305, ChEBI:CHEBI:356416; EC=2.3.1.37; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12922; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1. Homodimer. Interacts with SUCLA2. Mitochondrion inner membrane ; Peripheral membrane protein Mitochondrion Note=Localizes to the matrix side of the mitochondrion inner membrane. Predomnantly expressed in erythroid cells. C-terminus is a mobile self-inhibitory loop which interferes directly with active site. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Sequence=AAA37207.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; response to hypoxia catalytic activity 5-aminolevulinate synthase activity mitochondrion mitochondrial inner membrane mitochondrial matrix porphyrin-containing compound metabolic process protoporphyrinogen IX biosynthetic process heme biosynthetic process cellular iron ion homeostasis biosynthetic process glycine binding transferase activity transferase activity, transferring acyl groups pyridoxal phosphate binding erythrocyte differentiation tetrapyrrole biosynthetic process hemoglobin biosynthetic process coenzyme binding uc009uoj.1 uc009uoj.2 uc009uoj.3 
ENSMUST00000066352.6 Ptrh1 ENSMUST00000066352.6 peptidyl-tRNA hydrolase 1 homolog (from RefSeq NM_178595.4) ENSMUST00000066352.1 ENSMUST00000066352.2 ENSMUST00000066352.3 ENSMUST00000066352.4 ENSMUST00000066352.5 NM_178595 PTH_MOUSE Ptrh1 Q8BW00 uc008jgx.1 uc008jgx.2 uc008jgx.3 Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes (By similarity). Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes (By similarity). Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation (By similarity). Reaction=an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L- amino acid + H(+); Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123, Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191; EC=3.1.1.29; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54449; Evidence=; Belongs to the PTH family. aminoacyl-tRNA hydrolase activity mitochondrion hydrolase activity uc008jgx.1 uc008jgx.2 uc008jgx.3 
ENSMUST00000066368.13 Mdfi ENSMUST00000066368.13 MyoD family inhibitor, transcript variant 2 (from RefSeq NM_001109973.2) ENSMUST00000066368.1 ENSMUST00000066368.10 ENSMUST00000066368.11 ENSMUST00000066368.12 ENSMUST00000066368.2 ENSMUST00000066368.3 ENSMUST00000066368.4 ENSMUST00000066368.5 ENSMUST00000066368.6 ENSMUST00000066368.7 ENSMUST00000066368.8 ENSMUST00000066368.9 MDFI_MOUSE NM_001109973 P70330 P70331 P70332 Q5XK64 Q99JM9 uc008cwi.1 uc008cwi.2 uc008cwi.3 uc008cwi.4 Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA- binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. The C-terminus interacts with AXIN1 and LEF1 (PubMed:12192039). Interacts with CCNT2 (By similarity). Nucleus. Cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=I-mfB; IsoId=P70331-1; Sequence=Displayed; Name=I-mfA; IsoId=P70331-2; Sequence=VSP_004056; Name=I-mfC; IsoId=P70331-3; Sequence=VSP_004055, VSP_004057; In the embryo, highly expressed in the sclerotome. Also expressed in the notochord, neural tube, limb buds, heart, branchial arches and head mesenchyme. In the adult, highly expressed in skeletal muscle. Expressed at lower levels in most other tissues. Belongs to the MDFI family. negative regulation of transcription from RNA polymerase II promoter protein binding nucleus cytoplasm activation of JUN kinase activity multicellular organism development transcription factor binding dorsal/ventral axis specification regulation of Wnt signaling pathway cell differentiation negative regulation of Wnt signaling pathway identical protein binding negative regulation of DNA binding embryonic skeletal system morphogenesis trophoblast giant cell differentiation uc008cwi.1 uc008cwi.2 uc008cwi.3 uc008cwi.4 
ENSMUST00000066379.11 Chchd3 ENSMUST00000066379.11 coiled-coil-helix-coiled-coil-helix domain containing 3, transcript variant 1 (from RefSeq NM_025336.2) ENSMUST00000066379.1 ENSMUST00000066379.10 ENSMUST00000066379.2 ENSMUST00000066379.3 ENSMUST00000066379.4 ENSMUST00000066379.5 ENSMUST00000066379.6 ENSMUST00000066379.7 ENSMUST00000066379.8 ENSMUST00000066379.9 MIC19_MOUSE Mic19 NM_025336 Q9CRB9 uc009bgo.1 uc009bgo.2 uc009bgo.3 Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex (By similarity). Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form. Mitochondrion inner membrane ; Lipid-anchor ; Intermembrane side Cytoplasm Nucleus Mitochondrion Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic19 subfamily. negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding nucleus cytoplasm mitochondrion mitochondrial inner membrane inner mitochondrial membrane organization mitochondrial fusion membrane phosphatase binding cristae formation binding, bridging MICOS complex uc009bgo.1 uc009bgo.2 uc009bgo.3 
ENSMUST00000066386.6 Lysmd1 ENSMUST00000066386.6 LysM, putative peptidoglycan-binding, domain containing 1 (from RefSeq NM_153121.2) ENSMUST00000066386.1 ENSMUST00000066386.2 ENSMUST00000066386.3 ENSMUST00000066386.4 ENSMUST00000066386.5 LYSM1_MOUSE NM_153121 Q9D0E3 uc008qie.1 uc008qie.2 uc008qie.3 uc008qie.4 molecular_function nucleus nucleoplasm biological_process uc008qie.1 uc008qie.2 uc008qie.3 uc008qie.4 
ENSMUST00000066387.6 Rdh8 ENSMUST00000066387.6 retinol dehydrogenase 8 (from RefSeq NM_001030290.2) D3Z6W3 D3Z6W3_MOUSE ENSMUST00000066387.1 ENSMUST00000066387.2 ENSMUST00000066387.3 ENSMUST00000066387.4 ENSMUST00000066387.5 NM_001030290 Rdh8 uc009ojh.1 uc009ojh.2 uc009ojh.3 Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. Reaction=all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH; Xref=Rhea:RHEA:25033, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.300; Evidence=; Membrane Belongs to the short-chain dehydrogenases/reductases (SDR) family. estradiol 17-beta-dehydrogenase activity retinol dehydrogenase activity cytoplasm estrogen biosynthetic process visual perception oxidoreductase activity retinol metabolic process oxidation-reduction process uc009ojh.1 uc009ojh.2 uc009ojh.3 
ENSMUST00000066408.6 Liat1 ENSMUST00000066408.6 ligand of ATE1 (from RefSeq NM_198637.2) ENSMUST00000066408.1 ENSMUST00000066408.2 ENSMUST00000066408.3 ENSMUST00000066408.4 ENSMUST00000066408.5 LIAT1_MOUSE Liat1 NM_198637 Q810M6 uc007key.1 uc007key.2 uc007key.3 Participates in nucleolar liquid-liquid phase separation (LLPS) through its N-terminal intrinsically disordered region (IDR) (PubMed:33443146). May be involved in ATE1-mediated N-terminal arginylation (PubMed:25369936). Self-associates (via Lys-rich domain); targets LIAT1 to the nucleolus (PubMed:33443146). Interacts with ATE1; it is not a substrate of ATE1, the interaction takes place in the cytoplasm and seems to increase ATE1 arginyltransferase activity (PubMed:25369936, PubMed:33443146). Interacts with JMJD6 and MRPS14 (PubMed:25369936). Nucleus, nucleolus Cytoplasm Note=Shuttles between the cytoplasm and nucleoplasm, a significant portion localizes to the nucleolus. Highly expressed in spleen, thymus, liver and brown adipose tissue. Moderately expressed in liver, testis and lung. The N-terminal intrinsically disordered region (IDR) facilitates its liquid-liquid phase separation (LLPS) in the nucleolus (PubMed:33443146). In the IDR, the lysine-rich domain mediates self- association and targeting to the nucleolus (PubMed:33443146). LIAT1 proteins of some primates, from macaques to humans, contain tandem repeats of a 10-residue sequence, whereas LIAT1 proteins of other mammals contain a single copy of this motif. Quantities of these repeats are, in general, different in LIAT1 of different primates. For example, there are 1, 4, 13, 13, 17, and 17 repeats in the gibbon, gorilla, orangutan, bonobo, neanderthal, and human LIAT1, respectively. Post-translationally modified by JMJD6 lysyl-hydroxylase activity at its Lys-rich domain, which inhibits its self-association and nucleolar localization. protein binding cellular_component protein arginylation uc007key.1 uc007key.2 uc007key.3 
ENSMUST00000066412.8 Agtr1a ENSMUST00000066412.8 angiotensin II receptor, type 1a (from RefSeq NM_177322.3) AGTRA_MOUSE Agtr1 ENSMUST00000066412.1 ENSMUST00000066412.2 ENSMUST00000066412.3 ENSMUST00000066412.4 ENSMUST00000066412.5 ENSMUST00000066412.6 ENSMUST00000066412.7 NM_177322 P29754 uc007pyu.1 uc007pyu.2 uc007pyu.3 uc007pyu.4 Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. Interacts with MAS1 (By similarity). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity). P29754; Q9WVK0: Agtrap; NbExp=5; IntAct=EBI-765178, EBI-645964; Cell membrane ; Multi-pass membrane protein C-terminal Ser or Thr residues may be phosphorylated. Belongs to the G-protein coupled receptor 1 family. blood vessel development angiotensin type I receptor activity kidney development positive regulation of receptor recycling regulation of systemic arterial blood pressure by circulatory renin-angiotensin renin secretion into blood stream renin-angiotensin regulation of aldosterone production regulation of renal output by angiotensin brain renin-angiotensin system G-protein coupled receptor activity angiotensin type II receptor activity protein binding cytoplasm endosome Golgi apparatus plasma membrane regulation of pH inflammatory response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration Rho protein signal transduction heart development aging positive regulation of cell proliferation response to salt stress positive regulation of cholesterol esterification endomembrane system response to activity membrane integral component of membrane basolateral plasma membrane regulation of vasoconstriction calcium-mediated signaling protein kinase binding dendrite cytoplasmic vesicle bradykinin receptor binding D1 dopamine receptor binding organelle outer membrane positive regulation of cellular protein metabolic process positive regulation of phospholipase A2 activity positive regulation of superoxide anion generation regulation of smooth muscle cell apoptotic process negative regulation of smooth muscle cell apoptotic process angiotensin-activated signaling pathway vasoconstriction dopamine biosynthetic process drinking behavior activation of Janus kinase activity response to estrogen positive regulation of blood pressure protein heterodimerization activity positive regulation of cytokine secretion response to corticosterone positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway recycling endosome cell chemotaxis cellular response to dexamethasone stimulus phospholipase C-activating angiotensin-activated signaling pathway positive regulation of branching involved in ureteric bud morphogenesis positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of calcium ion import across plasma membrane response to angiotensin uc007pyu.1 uc007pyu.2 uc007pyu.3 uc007pyu.4 
ENSMUST00000066416.4 Defb38 ENSMUST00000066416.4 defensin beta 38 (from RefSeq NM_183036.2) DFB38_MOUSE ENSMUST00000066416.1 ENSMUST00000066416.2 ENSMUST00000066416.3 NM_183036 Q7TNV7 uc009laa.1 uc009laa.2 uc009laa.3 Synthetic Defb38 kills both Gram-negative (E.coli and P.aeruginosa) and Gram-positive (E.faecium) bacteria. Secreted. Only expressed in epididymis (caput, corpus and cauda). Belongs to the beta-defensin family. molecular_function cellular_component extracellular region defense response biological_process defense response to bacterium uc009laa.1 uc009laa.2 uc009laa.3 
ENSMUST00000066427.11 Sp100 ENSMUST00000066427.11 nuclear antigen Sp100, transcript variant 1 (from RefSeq NM_013673.4) ENSMUST00000066427.1 ENSMUST00000066427.10 ENSMUST00000066427.2 ENSMUST00000066427.3 ENSMUST00000066427.4 ENSMUST00000066427.5 ENSMUST00000066427.6 ENSMUST00000066427.7 ENSMUST00000066427.8 ENSMUST00000066427.9 NM_013673 Q8C405 Q8C405_MOUSE Sp100 uc007buh.1 uc007buh.2 uc007buh.3 uc007buh.4 uc007buh.5 Cytoplasm DNA binding nucleus uc007buh.1 uc007buh.2 uc007buh.3 uc007buh.4 uc007buh.5 
ENSMUST00000066437.5 Fam216b ENSMUST00000066437.5 family with sequence similarity 216, member B (from RefSeq NM_177629.4) ENSMUST00000066437.1 ENSMUST00000066437.2 ENSMUST00000066437.3 ENSMUST00000066437.4 F216B_MOUSE NM_177629 Q8CC14 uc007usg.1 uc007usg.2 uc007usg.3 Belongs to the FAM216 family. molecular_function cellular_component biological_process uc007usg.1 uc007usg.2 uc007usg.3 
ENSMUST00000066439.8 Exoc6 ENSMUST00000066439.8 exocyst complex component 6 (from RefSeq NM_175353.2) ENSMUST00000066439.1 ENSMUST00000066439.2 ENSMUST00000066439.3 ENSMUST00000066439.4 ENSMUST00000066439.5 ENSMUST00000066439.6 ENSMUST00000066439.7 Exoc6 NM_175353 Q3U9D6 Q3U9D6_MOUSE uc008hiq.1 uc008hiq.2 uc008hiq.3 uc008hiq.4 uc008hiq.5 Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC15 family. exocyst exocytosis vesicle docking involved in exocytosis uc008hiq.1 uc008hiq.2 uc008hiq.3 uc008hiq.4 uc008hiq.5 
ENSMUST00000066460.5 Bcl2a1c ENSMUST00000066460.5 B cell leukemia/lymphoma 2 related protein A1c (from RefSeq NM_007535.2) Bcl2a1c ENSMUST00000066460.1 ENSMUST00000066460.2 ENSMUST00000066460.3 ENSMUST00000066460.4 NM_007535 Q0P538 Q0P538_MOUSE uc009rxd.1 uc009rxd.2 Belongs to the Bcl-2 family. mitochondrial outer membrane intrinsic apoptotic signaling pathway in response to DNA damage protein homodimerization activity regulation of apoptotic process negative regulation of apoptotic process protein heterodimerization activity extrinsic apoptotic signaling pathway in absence of ligand uc009rxd.1 uc009rxd.2 
ENSMUST00000066465.3 Acsm5 ENSMUST00000066465.3 acyl-CoA synthetase medium-chain family member 5 (from RefSeq NM_178758.3) ACSM5_MOUSE ENSMUST00000066465.1 ENSMUST00000066465.2 Macs3 NM_178758 Q8BGA8 Q8BJS0 Q8BM02 Q8BWQ8 Q8BWS7 uc009jlf.1 uc009jlf.2 uc009jlf.3 Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Reaction=a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:48340, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:59558, ChEBI:CHEBI:90546, ChEBI:CHEBI:456215; EC=6.2.1.2; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48341; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGA8-1; Sequence=Displayed; Name=2; IsoId=Q8BGA8-2; Sequence=VSP_028399, VSP_028400; Belongs to the ATP-dependent AMP-binding enzyme family. nucleotide binding catalytic activity acyl-CoA ligase activity fatty-acyl-CoA synthase activity ATP binding mitochondrion mitochondrial matrix lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process acyl-CoA metabolic process fatty acid ligase activity ligase activity metal ion binding butyrate-CoA ligase activity uc009jlf.1 uc009jlf.2 uc009jlf.3 
ENSMUST00000066469.14 Cope ENSMUST00000066469.14 coatomer protein complex, subunit epsilon (from RefSeq NM_021538.2) COPE_MOUSE Cope1 ENSMUST00000066469.1 ENSMUST00000066469.10 ENSMUST00000066469.11 ENSMUST00000066469.12 ENSMUST00000066469.13 ENSMUST00000066469.2 ENSMUST00000066469.3 ENSMUST00000066469.4 ENSMUST00000066469.5 ENSMUST00000066469.6 ENSMUST00000066469.7 ENSMUST00000066469.8 ENSMUST00000066469.9 NM_021538 O89079 Q9JM65 uc009lzx.1 uc009lzx.2 uc009lzx.3 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Phosphorylated by PKA. Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation. Belongs to the COPE family. Golgi membrane structural molecule activity nucleoplasm cytoplasm Golgi apparatus ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER intra-Golgi vesicle-mediated transport protein transport membrane vesicle-mediated transport COPI vesicle coat COPI-coated vesicle COPI-coated vesicle membrane cytoplasmic vesicle uc009lzx.1 uc009lzx.2 uc009lzx.3 
ENSMUST00000066473.12 Madd ENSMUST00000066473.12 Cell membrane Cytoplasm Membrane (from UniProt E9QN47) AY263980 E9QKN1 E9QN47 E9QN47_MOUSE ENSMUST00000066473.1 ENSMUST00000066473.10 ENSMUST00000066473.11 ENSMUST00000066473.2 ENSMUST00000066473.3 ENSMUST00000066473.4 ENSMUST00000066473.5 ENSMUST00000066473.6 ENSMUST00000066473.7 ENSMUST00000066473.8 ENSMUST00000066473.9 Madd uc289yiv.1 uc289yiv.2 Cell membrane Cytoplasm Membrane Belongs to the MADD family. activation of MAPK activity cytosol plasma membrane integral component of membrane Rab guanyl-nucleotide exchange factor activity regulation of Rab protein signal transduction regulation of apoptotic process regulation of cell cycle execution phase of apoptosis regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of extrinsic apoptotic signaling pathway uc289yiv.1 uc289yiv.2 
ENSMUST00000066489.13 P3h4 ENSMUST00000066489.13 prolyl 3-hydroxylase family member 4 (non-enzymatic), transcript variant 2 (from RefSeq NM_176830.3) ENSMUST00000066489.1 ENSMUST00000066489.10 ENSMUST00000066489.11 ENSMUST00000066489.12 ENSMUST00000066489.2 ENSMUST00000066489.3 ENSMUST00000066489.4 ENSMUST00000066489.5 ENSMUST00000066489.6 ENSMUST00000066489.7 ENSMUST00000066489.8 ENSMUST00000066489.9 Leprel4 NM_176830 P3h4 Q8K2B0 SC65_MOUSE Sc65 uc007lla.1 uc007lla.2 uc007lla.3 uc007lla.4 Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils (PubMed:27119146). Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly (PubMed:23959653, PubMed:27119146, PubMed:28115524). Interacts with PLOD1, P3H3 and PPIB. Identified in a complex with PLOD1 and P3H3. Endoplasmic reticulum Detected in calvaria, cartilage, kidney, ribs, and at lower levels in tail (PubMed:23959653, PubMed:27119146). Detected in proliferating and prehypertrophic chondrocytes in the growth plate of long bones and in mineralizing chondro-osseus bone collar and cortical bone (PubMed:23959653). Detected on osteoblasts in long bones (PubMed:23959653, PubMed:27119146). Detected in skin fibroblasts (at protein level) (PubMed:27119146). Detected in fetal ribs, and in tibia and metatarsus from neonates (PubMed:23959653). No visible phenotype at birth (PubMed:23959653, PubMed:27119146, PubMed:28115524). Mice are born at the expected Mendelian rate (PubMed:23959653, PubMed:27119146). Two and six month old mutant mice display a decreased ratio between trabecular bone volume and tissue volume in tibia and femur, plus decreased connectivity density in femur and tibia (PubMed:23959653, PubMed:27119146). Osteoblast number is not affected, while osteoclast numbers are increased, suggesting that increased bone resorption is the cause for the low bone mass phenotype (PubMed:23959653). Lysine hydroxylation of skin and bone collagen alpha chains is strongly reduced (PubMed:27119146, PubMed:28115524). In contrast, prolyl 3- hydroxylation is not affected (PubMed:23959653, PubMed:27119146). Dorsal skin displays impaired packing of collagen fibrils, decreased skin tensile strength, decreased skin stiffness and increased skin fragility (PubMed:27119146, PubMed:28115524). Likewise, mice deficient for both P3h3 and P3h4 display decreased lysine hydroxylation of collagen alpha chains, but normal collagen prolyl 3-hydroxylation (PubMed:28115524). Belongs to the leprecan family. synaptonemal complex protein binding endoplasmic reticulum peptidyl-lysine hydroxylation collagen fibril organization collagen biosynthetic process bone remodeling catalytic complex uc007lla.1 uc007lla.2 uc007lla.3 uc007lla.4 
ENSMUST00000066496.10 Nudcd3 ENSMUST00000066496.10 NudC domain containing 3, transcript variant 5 (from RefSeq NR_185059.1) ENSMUST00000066496.1 ENSMUST00000066496.2 ENSMUST00000066496.3 ENSMUST00000066496.4 ENSMUST00000066496.5 ENSMUST00000066496.6 ENSMUST00000066496.7 ENSMUST00000066496.8 ENSMUST00000066496.9 Kiaa1068 NR_185059 NUDC3_MOUSE Q3TX16 Q5SVV6 Q5SVV7 Q6PFE4 Q6ZPZ2 Q8BL70 Q8BWN3 Q8BWW5 Q8R1N4 uc007hxy.1 uc007hxy.2 uc007hxy.3 uc007hxy.4 uc007hxy.5 Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8R1N4-1; Sequence=Displayed; Name=2; IsoId=Q8R1N4-2; Sequence=VSP_013678; Name=3; IsoId=Q8R1N4-3; Sequence=VSP_013679, VSP_013680; Name=4; IsoId=Q8R1N4-4; Sequence=VSP_013677; Sequence=BAC98086.1; Type=Erroneous initiation; Evidence=; cytoplasm cytoplasmic dynein complex protein folding developmental process unfolded protein binding cilium assembly uc007hxy.1 uc007hxy.2 uc007hxy.3 uc007hxy.4 uc007hxy.5 
ENSMUST00000066497.12 Zfp24 ENSMUST00000066497.12 zinc finger protein 24, transcript variant 1 (from RefSeq NM_021559.3) ENSMUST00000066497.1 ENSMUST00000066497.10 ENSMUST00000066497.11 ENSMUST00000066497.2 ENSMUST00000066497.3 ENSMUST00000066497.4 ENSMUST00000066497.5 ENSMUST00000066497.6 ENSMUST00000066497.7 ENSMUST00000066497.8 ENSMUST00000066497.9 Hmcns NM_021559 Q5MDG8 Q91VN1 Q9WUQ0 ZNF24_MOUSE Zfp191 Zfp24 Znf24 uc008egl.1 uc008egl.2 uc008egl.3 Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro. Nucleus Widely expressed with highest levels in heart, brain, liver, skeletal muscle, kidney and testis and very low levels in spleen and lung. In the embryo, barely detectable at day 17, peaks at day 11 and remains constant thereafter. Detected early during embryogenesis in ectodermal, endodermal, mesodermal and extraembryonic tissues. Expressed in the developing central nervous system. In the developing central nervous system (CNS), mainly expressed in progenitors. Sumoylated. According to PubMed:20080941, most mice die by postnatal day 25 (P25) due to myelination defects. Brains and spinal cords isolated from P14 mice appear to be smaller than those from wild- type mice and to lack white matter. Mutant oligodendrocytes arrest at a late stage of differentiation. Expression of genes expressed specifically in mature myelinating oligodendrocytes is down-regulated. According to PubMed:17064688, embryos are severely retarded in development and die at approximately 7.5 dpc. One possible explanation for the different phenotypes described is that the two null alleles are not identical. In the mutants described by PubMed:20080941, the PGK-neo cassette used for positive selection of embryonic stem (ES) cells has been removed, whereas it remains in the allele described by PubMed:17064688. Belongs to the krueppel C2H2-type zinc-finger protein family. transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated myelination sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding uc008egl.1 uc008egl.2 uc008egl.3 
ENSMUST00000066498.8 Tmem255a ENSMUST00000066498.8 transmembrane protein 255A, transcript variant 1 (from RefSeq NM_172930.4) ENSMUST00000066498.1 ENSMUST00000066498.2 ENSMUST00000066498.3 ENSMUST00000066498.4 ENSMUST00000066498.5 ENSMUST00000066498.6 ENSMUST00000066498.7 Fam70a NM_172930 Q6P5C9 Q8BHV8 Q8BHW5 Q8BHZ6 T255A_MOUSE uc009szr.1 uc009szr.2 uc009szr.3 uc009szr.4 uc009szr.5 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BHW5-1; Sequence=Displayed; Name=2; IsoId=Q8BHW5-2; Sequence=VSP_021922; Name=3; IsoId=Q8BHW5-3; Sequence=VSP_021923; Belongs to the TMEM255 family. molecular_function cellular_component response to bacterium membrane integral component of membrane uc009szr.1 uc009szr.2 uc009szr.3 uc009szr.4 uc009szr.5 
ENSMUST00000066529.5 Npr3 ENSMUST00000066529.5 natriuretic peptide receptor 3, transcript variant 1 (from RefSeq NM_008728.3) ANPRC_MOUSE ENSMUST00000066529.1 ENSMUST00000066529.2 ENSMUST00000066529.3 ENSMUST00000066529.4 G3X9E5 NM_008728 P70180 P97804 Q9R025 Q9R027 Q9R028 uc007vhf.1 uc007vhf.2 uc007vhf.3 uc007vhf.4 Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP (PubMed:10377427, PubMed:17951249). May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects (PubMed:10377427, PubMed:17951249). May regulate diuresis, blood pressure and skeletal development (PubMed:10377427). Does not have guanylate cyclase activity (PubMed:10377427). Homodimer; disulfide-linked (By similarity). Interacts with OSTN (PubMed:17951249). Cell membrane ; Single-pass type I membrane protein. Note=Defects in Npr3 are the cause of a number of skeletal- overgrowth phenotypes, Longjohn (Lgj), Longjohn-2J (Lgj-2J) and Strigosus (Stri). These are all recessive conditions characterized by an elongated body, thoracic kyphosis, arachnodactyly, and sacral and/or tail kinks, but no significant changes in craniofacial structures (PubMed:10468599). Half of the mice dies before weaning. They display reduced ability to concentrate urine, a lower blood pressure, and skeletal abnormalities. Despite a reduced half-life of NPPA in the circulation, the plasma levels of NPPA and NPPB are not affected. Has low affinity for peptide hormones in the absence of bound chloride. Belongs to the ANF receptor family. skeletal system development osteoclast proliferation adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity phospholipase C-activating G-protein coupled receptor signaling pathway regulation of blood pressure G-protein coupled peptide receptor activity membrane integral component of membrane natriuretic peptide receptor activity peptide hormone binding pancreatic juice secretion chloride ion binding macromolecular complex regulation of osteoblast proliferation positive regulation of urine volume peptide binding hormone binding protein homodimerization activity phosphatidylinositol-mediated signaling negative regulation of smooth muscle cell proliferation positive regulation of nitric-oxide synthase activity uc007vhf.1 uc007vhf.2 uc007vhf.3 uc007vhf.4 
ENSMUST00000066532.5 Lipg ENSMUST00000066532.5 lipase, endothelial (from RefSeq NM_010720.3) ENSMUST00000066532.1 ENSMUST00000066532.2 ENSMUST00000066532.3 ENSMUST00000066532.4 LIPG_MOUSE NM_010720 Q8VDU2 Q9WVG5 uc008fpu.1 uc008fpu.2 uc008fpu.3 Exerts both phospholipase and triglyceride lipase activities (By similarity). More active as a phospholipase than a triglyceride lipase (By similarity). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (By similarity). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (By similarity). Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + di-(9Z)-octadecenoylglycerol + H(+); Xref=Rhea:RHEA:38575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38576; Evidence=; Reaction=1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+); Xref=Rhea:RHEA:40475, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:35020, ChEBI:CHEBI:76478; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40476; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:41384, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41385; Evidence=; Head to tail homodimer. Secreted Expressed in placenta, lung, liver, testis and spleen. Belongs to the AB hydrolase superfamily. Lipase family. lipoprotein lipase activity phospholipase activity triglyceride lipase activity extracellular region extracellular space early endosome Golgi apparatus lipid metabolic process response to nutrient heparin binding cell proliferation phosphatidylcholine 1-acylhydrolase activity cell surface positive regulation of high-density lipoprotein particle clearance lipid catabolic process lipase activity hydrolase activity positive regulation of cholesterol transport high-density lipoprotein particle remodeling cholesterol homeostasis reverse cholesterol transport regulation of lipoprotein metabolic process carboxylic ester hydrolase activity phospholipid homeostasis uc008fpu.1 uc008fpu.2 uc008fpu.3 
ENSMUST00000066544.5 Dnajc5g ENSMUST00000066544.5 DnaJ heat shock protein family (Hsp40) member C5 gamma, transcript variant 1 (from RefSeq NM_177677.3) Dnajc5g ENSMUST00000066544.1 ENSMUST00000066544.2 ENSMUST00000066544.3 ENSMUST00000066544.4 NM_177677 Q8C632 Q8C632_MOUSE uc008wxc.1 uc008wxc.2 uc008wxc.3 Membrane ; Lipid- anchor molecular_function cellular_component biological_process uc008wxc.1 uc008wxc.2 uc008wxc.3 
ENSMUST00000066560.13 Glb1l2 ENSMUST00000066560.13 galactosidase, beta 1-like 2, transcript variant 2 (from RefSeq NM_001310768.1) E0CYE1 E0CYE1_MOUSE ENSMUST00000066560.1 ENSMUST00000066560.10 ENSMUST00000066560.11 ENSMUST00000066560.12 ENSMUST00000066560.2 ENSMUST00000066560.3 ENSMUST00000066560.4 ENSMUST00000066560.5 ENSMUST00000066560.6 ENSMUST00000066560.7 ENSMUST00000066560.8 ENSMUST00000066560.9 Glb1l2 NM_001310768 uc009opu.1 uc009opu.2 uc009opu.3 uc009opu.4 Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.; EC=3.2.1.23; Evidence=; Belongs to the glycosyl hydrolase 35 family. hydrolase activity, hydrolyzing O-glycosyl compounds beta-galactosidase activity carbohydrate metabolic process metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds uc009opu.1 uc009opu.2 uc009opu.3 uc009opu.4 
ENSMUST00000066568.6 Fpgt ENSMUST00000066568.6 fucose-1-phosphate guanylyltransferase (from RefSeq NM_029330.2) ENSMUST00000066568.1 ENSMUST00000066568.2 ENSMUST00000066568.3 ENSMUST00000066568.4 ENSMUST00000066568.5 FPGT_MOUSE Fpgt G5E8F4 NM_029330 Q2TB53 Q712G7 Q8C1A2 uc008ruu.1 uc008ruu.2 uc008ruu.3 uc008ruu.4 Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate (PubMed:14686921). Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids (Probable). Reaction=beta-L-fucose 1-phosphate + GTP + H(+) = diphosphate + GDP- beta-L-fucose; Xref=Rhea:RHEA:13549, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57268, ChEBI:CHEBI:57273; EC=2.7.7.30; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13550; Evidence=; Cytoplasm Expressed at highest levels in brain, moderately in testis, ovary and kidney, and weakly in liver, spleen, heart and lung. Sequence=BAC26043.1; Type=Frameshift; Evidence=; nucleotide binding molecular_function GTP binding cellular_component cytoplasm biological_process transferase activity transferase activity, transferring phosphorus-containing groups nucleotidyltransferase activity fucose-1-phosphate guanylyltransferase activity uc008ruu.1 uc008ruu.2 uc008ruu.3 uc008ruu.4 
ENSMUST00000066573.2 Aym1 ENSMUST00000066573.2 activator of yeast meiotic promoters 1 (from RefSeq NR_183840.1) ENSMUST00000066573.1 NR_183840 uc008yyg.1 uc008yyg.2 uc008yyg.1 uc008yyg.2 
ENSMUST00000066594.4 Sh2d4a ENSMUST00000066594.4 SH2 domain containing 4A (from RefSeq NM_028182.1) ENSMUST00000066594.1 ENSMUST00000066594.2 ENSMUST00000066594.3 NM_028182 Q14AV2 Q9D7V1 SH24A_MOUSE uc009lwe.1 uc009lwe.2 uc009lwe.3 uc009lwe.4 Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation (By similarity). May play a role in T-cell development and function. Interacts with ESR1. Cytoplasm Note=Located at podocyte foot processes. In the kidney, expressed only in the glomerulus. Expressed in T-cells, B-cells, macrophages and dendritic cells (at protein level). In adult, highest levels are found in muscle and lung with lower levels in kidney. Upon CD3/CD28 stimulation in CD4 T-cells. cytoplasm cytosol negative regulation of phosphatase activity phosphatase binding uc009lwe.1 uc009lwe.2 uc009lwe.3 uc009lwe.4 
ENSMUST00000066597.13 Klhl26 ENSMUST00000066597.13 kelch-like 26, transcript variant 2 (from RefSeq NM_178771.3) ENSMUST00000066597.1 ENSMUST00000066597.10 ENSMUST00000066597.11 ENSMUST00000066597.12 ENSMUST00000066597.2 ENSMUST00000066597.3 ENSMUST00000066597.4 ENSMUST00000066597.5 ENSMUST00000066597.6 ENSMUST00000066597.7 ENSMUST00000066597.8 ENSMUST00000066597.9 KLH26_MOUSE NM_178771 Q8BGY4 Q8CIG6 Q8R153 uc009mah.1 uc009mah.2 uc009mah.3 uc009mah.4 May play a role in endo(sarco)plasmic reticulum (ER/SR) mitochondrial signaling (By similarity). May be part of the ubiquitin- proteasome system (UPS) and affect ubiquitination and degradation of target substrates in cardiomyocytes (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BGY4-1; Sequence=Displayed; Name=2; IsoId=Q8BGY4-2; Sequence=VSP_019474; Name=3; IsoId=Q8BGY4-3; Sequence=VSP_019473; Sequence=AAH23909.1; Type=Erroneous initiation; Evidence=; uc009mah.1 uc009mah.2 uc009mah.3 uc009mah.4 
ENSMUST00000066601.13 Hyou1 ENSMUST00000066601.13 hypoxia up-regulated 1, transcript variant 1 (from RefSeq NM_021395.5) ENSMUST00000066601.1 ENSMUST00000066601.10 ENSMUST00000066601.11 ENSMUST00000066601.12 ENSMUST00000066601.2 ENSMUST00000066601.3 ENSMUST00000066601.4 ENSMUST00000066601.5 ENSMUST00000066601.6 ENSMUST00000066601.7 ENSMUST00000066601.8 ENSMUST00000066601.9 Grp170 HYOU1_MOUSE NM_021395 Q3TAL1 Q3TZD0 Q3U1U2 Q64139 Q80X75 Q9JKR6 uc009pdf.1 uc009pdf.2 uc009pdf.3 Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Endoplasmic reticulum lumen Belongs to the heat shock protein 70 family. nucleotide binding response to hypoxia response to ischemia ATP binding extracellular region endoplasmic reticulum endoplasmic reticulum lumen smooth endoplasmic reticulum ER to Golgi vesicle-mediated transport endoplasmic reticulum chaperone complex response to endoplasmic reticulum stress negative regulation of apoptotic process cellular response to hypoxia negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway uc009pdf.1 uc009pdf.2 uc009pdf.3 
ENSMUST00000066604.4 Kirrel3os ENSMUST00000066604.4 Kirrel3os (from geneSymbol) AK037951 ENSMUST00000066604.1 ENSMUST00000066604.2 ENSMUST00000066604.3 uc292fpd.1 uc292fpd.2 uc292fpd.1 uc292fpd.2 
ENSMUST00000066610.8 Inka2 ENSMUST00000066610.8 inka box actin regulator 2, transcript variant 1 (from RefSeq NM_175398.4) ENSMUST00000066610.1 ENSMUST00000066610.2 ENSMUST00000066610.3 ENSMUST00000066610.4 ENSMUST00000066610.5 ENSMUST00000066610.6 ENSMUST00000066610.7 Fam212b INKA2_MOUSE Inka2 NM_175398 Q80VY2 Q8C5H0 Q8CCA1 uc008qvc.1 uc008qvc.2 uc008qvc.3 Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity. Interacts with PAK4. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80VY2-1; Sequence=Displayed; Name=2; IsoId=Q80VY2-2; Sequence=VSP_028174; Enriched in the nervous system. During development, expressed in oligodendrocyte progenitor cells and in the proliferative neuronal progenitors in the developing cerebellum. In the embryonic brain, not expressed in immature newborn neurons, except for the cells residing in the marginal zone of the embryonic telencephalon. As brain development proceeds during the postnatal stage, expressed in some populations of immature neurons, including the neocortical pyramidal neurons, hippocampal pyramidal neurons and granule cells migrating in the cerebellar cortex. In the adult brain, expression is confined in terminally differentiated neurons in the restricted forebrain regions. The Inka box (also named iBox or inca box) binds and inhibits PAK4 by binding a substrate-like manner. Belongs to the INKA family. nucleus protein kinase binding protein serine/threonine kinase inhibitor activity negative regulation of protein serine/threonine kinase activity uc008qvc.1 uc008qvc.2 uc008qvc.3 
ENSMUST00000066640.5 Nanp ENSMUST00000066640.5 N-acetylneuraminic acid phosphatase (from RefSeq NM_026086.2) ENSMUST00000066640.1 ENSMUST00000066640.2 ENSMUST00000066640.3 ENSMUST00000066640.4 Hdhd4 NANP_MOUSE NM_026086 Q9CPT3 uc008muv.1 uc008muv.2 uc008muv.3 uc008muv.4 Reaction=an N-acylneuraminate 9-phosphate + H2O = an N-acylneuraminate + phosphate; Xref=Rhea:RHEA:13057, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57537, ChEBI:CHEBI:60073; EC=3.1.3.29; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by vanadate and calcium. Amino-sugar metabolism; N-acetylneuraminate biosynthesis. Belongs to the HAD-like hydrolase superfamily. NANP family. cellular_component carbohydrate metabolic process N-acetylglucosamine biosynthetic process dephosphorylation hydrolase activity N-acetylneuraminate biosynthetic process N-acylneuraminate-9-phosphatase activity uc008muv.1 uc008muv.2 uc008muv.3 uc008muv.4 
ENSMUST00000066646.12 Rcor2 ENSMUST00000066646.12 REST corepressor 2, transcript variant 2 (from RefSeq NM_054048.4) ENSMUST00000066646.1 ENSMUST00000066646.10 ENSMUST00000066646.11 ENSMUST00000066646.2 ENSMUST00000066646.3 ENSMUST00000066646.4 ENSMUST00000066646.5 ENSMUST00000066646.6 ENSMUST00000066646.7 ENSMUST00000066646.8 ENSMUST00000066646.9 NM_054048 Q8C796 Q9JMK4 RCOR2_MOUSE uc008gko.1 uc008gko.2 uc008gko.3 uc008gko.4 uc008gko.5 uc008gko.6 May act as a component of a corepressor complex that represses transcription. Q8C796; P70288: Hdac2; NbExp=2; IntAct=EBI-3043949, EBI-302251; Nucleus Predominantly, but not exclusively, expressed in neural tissue. Strongly expressed in neural domains of the developing brain of the developing mouse CNS. During early development (7 dpc to 8.5 dpc), it is uniformly distributed, with a higher expression in the presumptive neural tissue (head region) while it is not expressed in the heart. From 9 dpc on, it becomes increasingly restricted to the developing brain and spinal cord. With the exception of the floor plate, it is expressed in many cell clusters in the neural tube at that stage. Expressed in dorsal root ganglia and in the neural retina (sensory layer of the retina) of embryos from 11 dpc on throughout development. During mid-gestation, it is particularly expressed in neural tissue thereby shifting to the intermediate and distal layers of the expanding intraneural domains. From late gestational stages on, pronounced expression is detectable only in selected areas of the brain such as the retrospinal cortex. Expressed in neural cell layers in the hypothalamic region at postnatal day 5. In adult brains, it is expressed in many neural cells of the differentiated cortex. Expression is also observed in non-neural tissue such as the developing limbs where it becomes restricted to the interdigital areas. Strongly expressed in the odontoblast layer of the developing teeth and the maxillary bone. In the cerebellum, it is already expressed before the lobules form. At 14 dpc, it is uniformly distributed in the cerebellar rudiment. When lobulation becomes evident, expression is detectable only in the proliferating granule cells of the outermost layer (external granular layer). Belongs to the CoREST family. Sequence=CAB93943.1; Type=Erroneous initiation; Evidence=; chromatin DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus transcription factor complex transcription factor binding transcriptional repressor complex enzyme binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated uc008gko.1 uc008gko.2 uc008gko.3 uc008gko.4 uc008gko.5 uc008gko.6 
ENSMUST00000066650.12 Dbr1 ENSMUST00000066650.12 debranching RNA lariats 1, transcript variant 1 (from RefSeq NM_031403.3) DBR1_MOUSE ENSMUST00000066650.1 ENSMUST00000066650.10 ENSMUST00000066650.11 ENSMUST00000066650.2 ENSMUST00000066650.3 ENSMUST00000066650.4 ENSMUST00000066650.5 ENSMUST00000066650.6 ENSMUST00000066650.7 ENSMUST00000066650.8 ENSMUST00000066650.9 NM_031403 Q8C1T9 Q8C7J7 Q923B1 Q99MT1 uc009rei.1 uc009rei.2 uc009rei.3 Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover (PubMed:11355701). Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication and have an antiviral cell-intrinsic defense function (By similarity). Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 divalent metal cations per subunit. ; Active in presence of diverse metals including Fe(2+), Zn(2+), Mn(2+) (By similarity). Also activated by Ca(2+) (By similarity). Binds two metal cations in two adjacent alpha and beta metal-binding pockets (By similarity). Nucleus Belongs to the lariat debranching enzyme family. Sequence=AAK18789.1; Type=Frameshift; Evidence=; RNA splicing, via transesterification reactions mRNA splicing, via spliceosome nucleus nucleoplasm mRNA processing RNA lariat debranching enzyme activity hydrolase activity hydrolase activity, acting on ester bonds metal ion binding RNA phosphodiester bond hydrolysis, endonucleolytic uc009rei.1 uc009rei.2 uc009rei.3 
ENSMUST00000066668.14 Dnpep ENSMUST00000066668.14 Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism (By similarity). (from UniProt Q9Z2W0) AK038646 DNPEP_MOUSE Dnpep ENSMUST00000066668.1 ENSMUST00000066668.10 ENSMUST00000066668.11 ENSMUST00000066668.12 ENSMUST00000066668.13 ENSMUST00000066668.2 ENSMUST00000066668.3 ENSMUST00000066668.4 ENSMUST00000066668.5 ENSMUST00000066668.6 ENSMUST00000066668.7 ENSMUST00000066668.8 ENSMUST00000066668.9 Q56A00 Q9Z2W0 uc011wnp.1 uc011wnp.2 uc011wnp.3 Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism (By similarity). Reaction=Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.; EC=3.4.11.21; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; One of the zinc ions is readily exchangeable with other divalent cations such as manganese, which strongly stimulates the enzymatic activity. Tetrahedron-shaped homododecamer built from six homodimers. Cytoplasm. Ubiquitous. Belongs to the peptidase M18 family. aminopeptidase activity cytoplasm cytosol proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity identical protein binding metal ion binding metalloaminopeptidase activity uc011wnp.1 uc011wnp.2 uc011wnp.3 
ENSMUST00000066674.8 Car8 ENSMUST00000066674.8 carbonic anhydrase 8, transcript variant 1 (from RefSeq NM_007592.4) CAH8_MOUSE Ca8 Cals Cals1 Carp ENSMUST00000066674.1 ENSMUST00000066674.2 ENSMUST00000066674.3 ENSMUST00000066674.4 ENSMUST00000066674.5 ENSMUST00000066674.6 ENSMUST00000066674.7 NM_007592 P28651 Q8CF58 Q91XF6 uc008rxv.1 uc008rxv.2 uc008rxv.3 Does not have a carbonic anhydrase catalytic activity. Expressed only in Purkinje cells. Belongs to the alpha-carbonic anhydrase family. Although it belongs to the alpha-carbonic anhydrase family, Arg-117 is present instead of the conserved His which is a zinc-binding residue. It is therefore expected that this protein lacks carbonic anhydrase activity. carbonate dehydratase activity protein binding cytoplasm zinc ion binding metal ion binding phosphatidylinositol-mediated signaling uc008rxv.1 uc008rxv.2 uc008rxv.3 
ENSMUST00000066675.10 Mtif3 ENSMUST00000066675.10 mitochondrial translational initiation factor 3, transcript variant 3 (from RefSeq NM_029581.4) ENSMUST00000066675.1 ENSMUST00000066675.2 ENSMUST00000066675.3 ENSMUST00000066675.4 ENSMUST00000066675.5 ENSMUST00000066675.6 ENSMUST00000066675.7 ENSMUST00000066675.8 ENSMUST00000066675.9 IF3M_MOUSE NM_029581 Q14BP1 Q14BP2 Q9CZD5 uc009anp.1 uc009anp.2 uc009anp.3 uc009anp.4 IF-3 binds to the 28S ribosomal subunit and shifts the equilibrium between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. Mitochondrion Belongs to the IF-3 family. translation initiation factor activity mitochondrion translation translational initiation translation factor activity, RNA binding ribosome disassembly ribosome binding ribosomal small subunit binding mitochondrial translational initiation uc009anp.1 uc009anp.2 uc009anp.3 uc009anp.4 
ENSMUST00000066679.7 Shisa6 ENSMUST00000066679.7 shisa family member 6, transcript variant 2 (from RefSeq NM_001034874.4) A0A172Q417 ENSMUST00000066679.1 ENSMUST00000066679.2 ENSMUST00000066679.3 ENSMUST00000066679.4 ENSMUST00000066679.5 ENSMUST00000066679.6 Gm879 NM_001034874 Q3UH99 SHSA6_MOUSE Shisa6 uc007jlm.1 uc007jlm.2 uc007jlm.3 uc007jlm.4 Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (PubMed:26931375). May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway (PubMed:28196692). Component of the postsynaptic hippocampal AMPA-type glutamate receptor (AMPAR) complex, at least composed of pore forming AMPAR subunits GRIA1, GRIA2 and GRIA3 and AMPAR auxiliary proteins SHISA6 and SHISA7 (PubMed:26931375, PubMed:29199957). Interacts (via PDZ-binding motif) with DLG4/PSD-95 (via PDZ domain); the interaction is direct (PubMed:26931375). Postsynaptic density membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UH99-1; Sequence=Displayed; Name=2; IsoId=Q3UH99-2; Sequence=VSP_059384; Highly expressed in cerebellum and hippocampal neurons: CA1 stratum oriens and stratum radiatum, CA3 stratum oriens and stratum lucidum, and the dentate gyrus polymorphic layer (PubMed:26931375). Expressed in other brain structures including olfactory bulb, cortex, amygdala and midbrain (at protein level) (PubMed:26623514, PubMed:26931375). Also expressed in a subset of spermatogonial stem cells (PubMed:28196692). Also expressed in eye, heart, kidney, lung, muscle and spleen. Isoform 2: Specifically expressed in hippocampus (PubMed:26931375). Barely detectable in the brain of embryonic day 17 (17 dpc). Expressed in hippocampus and septum from postnatal day 1 (P1) and then in cerebellum and olfactory bulb from postnatal day 7 (P7). The PDZ-binding motif interacts with PDZ-domain of scaffolding protein DLG4. N-glycosylated. Decreases decay times of miniature excitatory postsynaptic currents (mEPSCs) and light-induced AMPA-type glutamate receptor (AMPAR) currents in CA1 pyramidal cell. Belongs to the shisa family. plasma membrane spermatogenesis postsynaptic density membrane integral component of membrane Wnt signaling pathway cell junction PDZ domain binding AMPA glutamate receptor complex dendritic spine membrane ionotropic glutamate receptor binding synapse postsynaptic membrane regulation of short-term neuronal synaptic plasticity negative regulation of canonical Wnt signaling pathway regulation of postsynaptic neurotransmitter receptor activity postsynaptic neurotransmitter receptor diffusion trapping excitatory chemical synaptic transmission glutamatergic synapse asymmetric, glutamatergic, excitatory synapse integral component of postsynaptic density membrane regulation of AMPA glutamate receptor clustering regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc007jlm.1 uc007jlm.2 uc007jlm.3 uc007jlm.4 
ENSMUST00000066701.13 Ifi27 ENSMUST00000066701.13 interferon, alpha-inducible protein 27, transcript variant 3 (from RefSeq NM_194067.2) D12Ertd647e ENSMUST00000066701.1 ENSMUST00000066701.10 ENSMUST00000066701.11 ENSMUST00000066701.12 ENSMUST00000066701.2 ENSMUST00000066701.3 ENSMUST00000066701.4 ENSMUST00000066701.5 ENSMUST00000066701.6 ENSMUST00000066701.7 ENSMUST00000066701.8 ENSMUST00000066701.9 ISG12a Ifi27 Ifi27l1 NM_194067 Q9D1E1 Q9D1E1_MOUSE uc007ovq.1 uc007ovq.2 uc007ovq.3 uc007ovq.4 Membrane ; Multi- pass membrane protein Belongs to the IFI6/IFI27 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding lamin binding nuclear inner membrane mitochondrion integral component of membrane regulation of protein export from nucleus uc007ovq.1 uc007ovq.2 uc007ovq.3 uc007ovq.4 
ENSMUST00000066708.7 Dmp1 ENSMUST00000066708.7 dentin matrix protein 1, transcript variant 2 (from RefSeq NM_016779.2) DMP1_MOUSE Dmp Dmp1 ENSMUST00000066708.1 ENSMUST00000066708.2 ENSMUST00000066708.3 ENSMUST00000066708.4 ENSMUST00000066708.5 ENSMUST00000066708.6 NM_016779 O55188 Q3TZB6 uc008yke.1 uc008yke.2 uc008yke.3 May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast- specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity). Interacts with importin alpha. Nucleus Cytoplasm Secreted, extracellular space, extracellular matrix Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus (By similarity). Expressed in tooth particularly in odontoblast, ameloblast and cementoblast. Also expressed in bone particularly in osteoblast. Expressed in early bell stage dental mesenchymal cells at 15.5 dpc (at protein level) (PubMed:24028588). Expressed in bell stage dental mesenchymal cells at 17.5 dpc (PubMed:29148101). Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif (By similarity). Mice display rickets and osteomalacia with isolated renal phosphate wasting associated with elevated FGF23 levels and normocalciuria. ossification extracellular region nucleus cytoplasm positive regulation of cell-substrate adhesion extracellular matrix organization Hsp70 protein binding extracellular matrix biomineral tissue development extracellular matrix binding regulation of enamel mineralization uc008yke.1 uc008yke.2 uc008yke.3 
ENSMUST00000066715.11 Zbtb48 ENSMUST00000066715.11 zinc finger and BTB domain containing 48, transcript variant 1 (from RefSeq NM_133879.3) A2A8B1 ENSMUST00000066715.1 ENSMUST00000066715.10 ENSMUST00000066715.2 ENSMUST00000066715.3 ENSMUST00000066715.4 ENSMUST00000066715.5 ENSMUST00000066715.6 ENSMUST00000066715.7 ENSMUST00000066715.8 ENSMUST00000066715.9 Hkr3 NM_133879 Q1H9T6 Q99K15 TZAP_MOUSE Tzap Zbtb48 uc008vyz.1 uc008vyz.2 uc008vyz.3 Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A. Interacts with EP300. Nucleus Chromosome, telomere Note=Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2. According to another report, binds telomeres regardless of their length. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q1H9T6-1; Sequence=Displayed; Name=2; IsoId=Q1H9T6-2; Sequence=VSP_026381; The C2H2-type zinc fingers mediate binding to the telomeric double-stranded 5'-TTAGGG-3' repeats. The last C2H2-type zinc finger is required for telomeric-binding. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=CAM24576.2; Type=Erroneous gene model prediction; Evidence=; chromosome, telomeric region nucleic acid binding DNA binding double-stranded telomeric DNA binding nucleus nucleoplasm chromosome cytosol telomere maintenance via telomere lengthening identical protein binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated metal ion binding uc008vyz.1 uc008vyz.2 uc008vyz.3 
ENSMUST00000066723.15 Lgals4 ENSMUST00000066723.15 lectin, galactose binding, soluble 4, transcript variant 3 (from RefSeq NR_182022.1) ENSMUST00000066723.1 ENSMUST00000066723.10 ENSMUST00000066723.11 ENSMUST00000066723.12 ENSMUST00000066723.13 ENSMUST00000066723.14 ENSMUST00000066723.2 ENSMUST00000066723.3 ENSMUST00000066723.4 ENSMUST00000066723.5 ENSMUST00000066723.6 ENSMUST00000066723.7 ENSMUST00000066723.8 ENSMUST00000066723.9 LEG4_MOUSE NR_182022 O88353 Q8K419 Q91X74 uc009gac.1 uc009gac.2 uc009gac.3 uc009gac.4 Galectin that binds lactose and a related range of sugars. Monomer. Epithelial cells of the embryonic and adult gastrointestinal tract. Expressed at about equal levels in colon and small intestine but much less in stomach. Contains two homologous but distinct carbohydrate-binding domains. Name=Functional Glycomics Gateway - Glycan Binding; Note=Galectin-4; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Stlect_200"; protein binding extracellular space galactoside binding carbohydrate binding uc009gac.1 uc009gac.2 uc009gac.3 uc009gac.4 
ENSMUST00000066740.5 A730045E13Rik ENSMUST00000066740.5 A730045E13Rik (from geneSymbol) AK042983 ENSMUST00000066740.1 ENSMUST00000066740.2 ENSMUST00000066740.3 ENSMUST00000066740.4 uc291yts.1 uc291yts.2 uc291yts.1 uc291yts.2 
ENSMUST00000066742.5 Gm9930 ENSMUST00000066742.5 Gm9930 (from geneSymbol) AK032987 ENSMUST00000066742.1 ENSMUST00000066742.2 ENSMUST00000066742.3 ENSMUST00000066742.4 uc056yge.1 uc056yge.2 uc056yge.1 uc056yge.2 
ENSMUST00000066743.11 Adnp2 ENSMUST00000066743.11 ADNP homeobox 2 (from RefSeq NM_175028.1) ADNP2_MOUSE ENSMUST00000066743.1 ENSMUST00000066743.10 ENSMUST00000066743.2 ENSMUST00000066743.3 ENSMUST00000066743.4 ENSMUST00000066743.5 ENSMUST00000066743.6 ENSMUST00000066743.7 ENSMUST00000066743.8 ENSMUST00000066743.9 Kiaa0863 NM_175028 Q6P294 Q80VS0 Q811H5 Q8CHC8 Q8R1A2 Zfp508 Znf508 uc008fsk.1 uc008fsk.2 uc008fsk.3 May be involved in transcriptional regulation (PubMed:23071114). May play a role in neuronal function; perhaps involved in protection of brain tissues from oxidative stress (PubMed:18179478). May be involved in erythroid differentiation (PubMed:23071114). May interact with SMARCA4/BRG1. Nucleus Expressed widely, with the highest level in the brain. Expressed at 7.5 dpc, increasing by 9.5 dpc, concomitant with cranial neural tube closure, and at 11.5 dpc (PubMed:18179478). Expression levels were relatively stable between 12.5 dpc and birth, continuing into adulthood (PubMed:18179478). Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAH24969.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH44898.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC41452.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function nucleic acid binding DNA binding cellular_component nucleus neuron differentiation positive regulation of cell growth cellular response to oxidative stress metal ion binding negative regulation of cell death cellular response to retinoic acid uc008fsk.1 uc008fsk.2 uc008fsk.3 
ENSMUST00000066747.14 Cd8a ENSMUST00000066747.14 CD8 subunit alpha, transcript variant 1 (from RefSeq NM_001081110.2) CD8A_MOUSE ENSMUST00000066747.1 ENSMUST00000066747.10 ENSMUST00000066747.11 ENSMUST00000066747.12 ENSMUST00000066747.13 ENSMUST00000066747.2 ENSMUST00000066747.3 ENSMUST00000066747.4 ENSMUST00000066747.5 ENSMUST00000066747.6 ENSMUST00000066747.7 ENSMUST00000066747.8 ENSMUST00000066747.9 Lyt-2 Lyt2 NM_001081110 P01731 uc009cgr.1 uc009cgr.2 uc009cgr.3 Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T- lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. Forms disulfide-linked heterodimers with CD8B at the cell surface. Forms also homodimers in several cell types including NK-cells or peripheral blood T-lymphocytes. Interacts with the MHC class I HLA- A/B2M dimer. Interacts with LCK in a zinc-dependent manner. P01731; P06240: Lck; NbExp=2; IntAct=EBI-1433, EBI-1401; Cell membrane ; Single-pass type I membrane protein Note=Cd8a localizes to lipid rafts only when associated with its partner Cd8b. Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced. Alternative splicing involves excision of the transmembrane or cytoplasmic domains.; Name=1; IsoId=P01731-1; Sequence=Displayed; Palmitoylated, but association with CD8B seems to be more important for the enrichment of CdD8A in lipid rafts. Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation. Cd8a-deficient mice prevent the development of class I MHC restricted cytotoxic T-cells. However, maturation of class II MHC restricted T-helper cells seems to be unaffected by the absence of Cd8a. adaptive immune response immune system process T cell mediated immunity protein binding plasma membrane cell surface receptor signaling pathway external side of plasma membrane cell surface membrane integral component of membrane protein kinase binding MHC class I protein complex binding T cell activation identical protein binding plasma membrane raft cytotoxic T cell differentiation positive regulation of calcium-mediated signaling defense response to virus uc009cgr.1 uc009cgr.2 uc009cgr.3 
ENSMUST00000066760.8 Senp3 ENSMUST00000066760.8 SUMO/sentrin specific peptidase 3, transcript variant 2 (from RefSeq NM_001163571.1) ENSMUST00000066760.1 ENSMUST00000066760.2 ENSMUST00000066760.3 ENSMUST00000066760.4 ENSMUST00000066760.5 ENSMUST00000066760.6 ENSMUST00000066760.7 NM_001163571 Q5F2A5 Q8BRD5 Q8C2H5 Q9EP97 SENP3_MOUSE Smt3ip Smt3ip1 uc007jrc.1 uc007jrc.2 uc007jrc.3 uc007jrc.4 Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:11029585). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (By similarity). Deconjugates SUMO2 and SUMO3 from CDCA8 (By similarity). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (By similarity). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (By similarity). Plays a role in the regulation of sumoylation status of ZNF148 (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (By similarity). On oxidative stress, SENP3 degradation is blocked by inhibition of its ubiquitination, which stabilizes it as it accumulates in the nucleoplasm. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Interacts with EP300, NPM1 and CDCA8 (By similarity). Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148 (PubMed:22872859). Interacts with NOL9 (PubMed:22872859). Interacts with CCAR2 (By similarity). Nucleus, nucleolus Nucleus, nucleoplasm Cytoplasm Note=Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (By similarity). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (PubMed:22872859). Belongs to the peptidase C48 family. thiol-dependent ubiquitin-specific protease activity protein binding nucleus nucleoplasm nucleolus cytoplasm proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity protein desumoylation protein metabolic process MLL1 complex uc007jrc.1 uc007jrc.2 uc007jrc.3 uc007jrc.4 
ENSMUST00000066774.6 Tusc1 ENSMUST00000066774.6 tumor suppressor candidate 1 (from RefSeq NM_026954.1) ENSMUST00000066774.1 ENSMUST00000066774.2 ENSMUST00000066774.3 ENSMUST00000066774.4 ENSMUST00000066774.5 NM_026954 Q673H1 Q9CVE2 TUSC1_MOUSE uc008tou.1 uc008tou.2 uc008tou.3 molecular_function cellular_component biological_process uc008tou.1 uc008tou.2 uc008tou.3 
ENSMUST00000066778.6 Pi4k2a ENSMUST00000066778.6 phosphatidylinositol 4-kinase type 2 alpha (from RefSeq NM_145501.2) ENSMUST00000066778.1 ENSMUST00000066778.2 ENSMUST00000066778.3 ENSMUST00000066778.4 ENSMUST00000066778.5 NM_145501 P4K2A_MOUSE Q2TBE6 uc008hng.1 uc008hng.2 uc008hng.3 Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4- phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216; EC=2.7.1.67; Evidence=; Associates with the BLOC-1 and the AP-3 complexes; the BLOC-1 complex is required for optimal binding of PI4K2A to the AP-3 complex (PubMed:21998198). Interacts with BLOC1S5 and DTNBP1 (By similarity). Interacts with ITCH (PubMed:23146885). Interacts with FOS; this interaction may enhance phosphatidylinositol phosphorylation activity (PubMed:22105363). Interacts with ATG9A (By similarity). Golgi apparatus, trans-Golgi network membrane ; Lipid-anchor Membrane raft Endosome Cytoplasmic vesicle Cell projection, dendrite Presynaptic cell membrane Synapse, synaptosome Mitochondrion Membrane ; Lipid-anchor Cell membrane Perikaryon Cell projection, neuron projection Note=Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. Transported from neuronal cell body to neuron projections and neurite tips in a BLOC-1- and AP-3- complexes-dependent manner (PubMed:21998198). Detected in brain (at protein level). Palmitoylated by ZDHHC3 and ZDHHC7 in the CCPCC motif. Palmitoylation is cholesterol-dependent, and required for TGN localization (By similarity). Ubiquitinated by ITCH; this does not lead to proteasomal degradation. Mice are born at the expected Mendelian rate. Young animals have no visible phenotype, but oldeer mice develop urinary incontinence, head tremor, spastic gait, weakness of the hind limbs, followed by additional weakness of the forelimbs, weight loss and premature death. Their brains show no gross anatomical defects, but show loss of Purkinje cells. In addition, mice present massive axon degeneration in the ascending and descending tract of the spinal cord. Male mice are infertile and females are subfertile. Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. nucleotide binding basophil degranulation 1-phosphatidylinositol 4-kinase activity ATP binding mitochondrion endosome Golgi apparatus trans-Golgi network plasma membrane integral component of plasma membrane phosphatidylinositol biosynthetic process Golgi organization endosome organization membrane kinase activity phosphorylation transferase activity cell junction dendrite synaptic vesicle membrane intrinsic component of membrane cytoplasmic vesicle early endosome membrane macromolecular complex AP-3 adaptor complex binding growing cell tip presynaptic membrane cell projection neuron projection neuronal cell body perikaryon intracellular membrane-bounded organelle host cell presynaptic membrane macromolecular complex binding membrane raft synapse phosphatidylinositol phosphorylation exocytic vesicle BLOC-1 complex uc008hng.1 uc008hng.2 uc008hng.3 
ENSMUST00000066780.5 Mill1 ENSMUST00000066780.5 MHC I like leukocyte 1 (from RefSeq NM_153749.4) ENSMUST00000066780.1 ENSMUST00000066780.2 ENSMUST00000066780.3 ENSMUST00000066780.4 MILL1_MOUSE Mill1 NM_153749 Q8HWA4 Q8HWA5 Q8HWE7 uc009fjh.1 uc009fjh.2 Heterodimer with B2M. Cell membrane ; Lipid-anchor, GPI-anchor Expressed in stomach, intestine, uterus, skeletal muscle and heart. In neonatal animals, highly expressed in skin where it localizes to a region of the inner root sheath of hair follicles (at protein level) (PubMed:12370446, PubMed:16920948). Also expressed in thymic medullary epithelial cells (at protein level) (PubMed:12370446, PubMed:16920948). Detected in skeletal muscle, eyes, and submandibular glands (PubMed:12370446). N-glycosylated. Belongs to the MHC class I family. Lacks key residues involved in peptide docking and also does not require TAP (transporter involved in antigen processing) for cell surface expression, suggesting that this is a non-classical MHC class I protein which does not play a role in antigen presentation. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent protein binding extracellular space plasma membrane immune response external side of plasma membrane integral component of membrane anchored component of external side of plasma membrane uc009fjh.1 uc009fjh.2 
ENSMUST00000066791.7 Tmem179 ENSMUST00000066791.7 transmembrane protein 179 (from RefSeq NM_178915.3) ENSMUST00000066791.1 ENSMUST00000066791.2 ENSMUST00000066791.3 ENSMUST00000066791.4 ENSMUST00000066791.5 ENSMUST00000066791.6 NM_178915 Q78GD2 Q7TPP8 Q8BHH9 Q8BN09 T179A_MOUSE uc007per.1 uc007per.2 uc007per.3 Membrane ; Multi-pass membrane protein Belongs to the TMEM179 family. Sequence=BAC41142.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc007per.1 uc007per.2 uc007per.3 
ENSMUST00000066794.10 ENSMUSG00000121700 ENSMUST00000066794.10 ENSMUSG00000121700 (from geneSymbol) ENSMUST00000066794.1 ENSMUST00000066794.2 ENSMUST00000066794.3 ENSMUST00000066794.4 ENSMUST00000066794.5 ENSMUST00000066794.6 ENSMUST00000066794.7 ENSMUST00000066794.8 ENSMUST00000066794.9 LT629304 uc290dwk.1 uc290dwk.2 uc290dwk.3 uc290dwk.1 uc290dwk.2 uc290dwk.3 
ENSMUST00000066807.8 Ercc6 ENSMUST00000066807.8 excision repair cross-complementing rodent repair deficiency, complementation group 6 (from RefSeq NM_001081221.2) A3KMN2 Csb ENSMUST00000066807.1 ENSMUST00000066807.2 ENSMUST00000066807.3 ENSMUST00000066807.4 ENSMUST00000066807.5 ENSMUST00000066807.6 ENSMUST00000066807.7 ERCC6_MOUSE F8VPZ5 NM_001081221 uc007sze.1 uc007sze.2 uc007sze.3 Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (By similarity). It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-blocking lesions (By similarity). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (By similarity). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (By similarity). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing the premature exit from the G2/M checkpoint (By similarity). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (By similarity). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (By similarity). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (By similarity). Involved in UV-induced translocation of ERCC8 to the nuclear matrix (By similarity). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Homodimer (By similarity). Binds DNA (By similarity). Interacts with ERCC8 (By similarity). Interacts with RNA polymerase II; interaction is enhanced by UV irradiation (By similarity). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (By similarity). Interacts with KIAA1530/UVSSA (By similarity). Interacts with ELOA and CUL5; the interaction is induced by DNA damaging agents or by inhibitors of RNA polymerase II elongation (By similarity). Interacts (via WHD region) with RIF1 (By similarity). Interacts with SMARCC2/BAF170, SMARCB1/BAF47 and the neuron-specific chromatin remodeling complex (nBAF complex) (By similarity). Interacts with ERCC5/XPG (via C-terminus); the interaction stimulates ERCC6/CSB binding to DNA repair bubble and ERCC6/CSB ATPase activity (By similarity). May form a complex composed of RNA polymerase II, ERCC6/CSB and ERCC5/XPG which associates with the DNA repair bubble during transcription-coupled nucleotide excision repair (By similarity). Interacts with CAND1, CSTF1, DDX3X, DDX5, DDX17, DDX23, DHX36, HDAC1, HNRNPU, MTA2, PRPF3, PSMD3, RBBP4, SFPQ, SMARCA1, SMARCA2, TOP1, USP7 and XRCC5 (By similarity). Nucleus A C-terminal ubiquitin-binding domain (UBD) is essential for transcription-coupled nucleotide excision repair activity, interaction with RNA polymerase II, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. The N-terminal domain exerts an inhibitory effect on the helicase ATP-binding domain in such a manner that its ATPase activity is restricted (By similarity). Phosphorylation at Ser-158 promotes the intramolecular interaction of the N-terminal domain with the helicase ATP-binding domain, thereby probably releasing the inhibitory effect of the N-terminal domain on its ATPase activity (By similarity). Phosphorylated in a cell cycle-dependent manner at Ser-158 by cyclin A-CDK2 in response to DNA damage (By similarity). Phosphorylation at this site promotes the intramolecular interaction of the N-terminal domain with the helicase ATP-binding domain, thereby probably releasing the inhibitory effect of the N-terminal domain on its ATPase activity (By similarity). Phosphorylation is essential for its chromatin remodeling activity (By similarity). Ubiquitinated at the C-terminus (By similarity). Ubiquitination by the CSA complex leads to ERCC6 proteasomal degradation in a UV- dependent manner (By similarity). Stabilized following interaction with KIAA1530/UVSSA, which promotes recruitment of deubiquitinating enzyme USP7, leading to deubiquitination of ERCC6 thereby preventing UV- induced degradation of ERCC6 by the proteasome (By similarity). Belongs to the SNF2/RAD54 helicase family. response to superoxide positive regulation of defense response to virus by host DNA binding chromatin binding ATP binding nucleus nucleoplasm nucleolus DNA repair transcription-coupled nucleotide-excision repair base-excision repair pyrimidine dimer repair transcription elongation from RNA polymerase I promoter cellular response to DNA damage stimulus response to oxidative stress activation of JNKK activity activation of JUN kinase activity protein C-terminus binding transcription elongation factor complex DNA-dependent ATPase activity intrinsic apoptotic signaling pathway in response to DNA damage response to UV response to toxic substance response to X-ray response to UV-B response to gamma radiation positive regulation of gene expression protein tyrosine kinase activator activity regulation of DNA-templated transcription, elongation positive regulation of DNA-templated transcription, elongation positive regulation of peptidyl-serine phosphorylation of STAT protein multicellular organism growth sequence-specific DNA binding macromolecular complex binding photoreceptor cell maintenance positive regulation of DNA repair protein N-terminus binding positive regulation of protein tyrosine kinase activity RNA polymerase binding uc007sze.1 uc007sze.2 uc007sze.3 
ENSMUST00000066814.7 Adam39 ENSMUST00000066814.7 a disintegrin and metallopeptidase domain 39 (from RefSeq NM_001025380.3) Adam39 ENSMUST00000066814.1 ENSMUST00000066814.2 ENSMUST00000066814.3 ENSMUST00000066814.4 ENSMUST00000066814.5 ENSMUST00000066814.6 NM_001025380 Q7M762 Q7M762_MOUSE uc009lne.1 uc009lne.2 uc009lne.3 Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function metalloendopeptidase activity cellular_component proteolysis biological_process metallopeptidase activity membrane integral component of membrane uc009lne.1 uc009lne.2 uc009lne.3 
ENSMUST00000066819.11 Tceal5 ENSMUST00000066819.11 transcription elongation factor A (SII)-like 5, transcript variant 1 (from RefSeq NM_177919.3) ENSMUST00000066819.1 ENSMUST00000066819.10 ENSMUST00000066819.2 ENSMUST00000066819.3 ENSMUST00000066819.4 ENSMUST00000066819.5 ENSMUST00000066819.6 ENSMUST00000066819.7 ENSMUST00000066819.8 ENSMUST00000066819.9 NM_177919 Q497R6 Q8CCT4 TCAL5_MOUSE uc009uif.1 uc009uif.2 uc009uif.3 May be involved in transcriptional regulation. Nucleus Belongs to the TFS-II family. TFA subfamily. nucleus WW domain binding uc009uif.1 uc009uif.2 uc009uif.3 
ENSMUST00000066824.14 Sgip1 ENSMUST00000066824.14 SH3-domain GRB2-like (endophilin) interacting protein 1, transcript variant 3 (from RefSeq NM_001285859.1) A7BFW0 ENSMUST00000066824.1 ENSMUST00000066824.10 ENSMUST00000066824.11 ENSMUST00000066824.12 ENSMUST00000066824.13 ENSMUST00000066824.2 ENSMUST00000066824.3 ENSMUST00000066824.4 ENSMUST00000066824.5 ENSMUST00000066824.6 ENSMUST00000066824.7 ENSMUST00000066824.8 ENSMUST00000066824.9 NM_001285859 Q3UFU3 Q3UGA0 Q8BXX4 Q8C034 Q8VD37 Q9CXT2 SGIP1_MOUSE uc008twr.1 uc008twr.2 uc008twr.3 uc008twr.4 May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. Interacts with proteins essential or regulating the formation of functional clathrin-coated pits (Probable). Interacts with CANX (PubMed:17626015, PubMed:21747946). Interacts with AP2A1 (PubMed:17626015). Interacts with EPS15 (PubMed:17626015). Interacts with SH3GL3 (By similarity). Interacts with AMPH (By similarity). Interacts with ITSN1 (via SH3 domains) (By similarity). Interacts with and REPS1 (By similarity). Q8VD37; P35564: Canx; NbExp=3; IntAct=EBI-776269, EBI-738422; Q8VD37; A7BFV9: Eps15; Xeno; NbExp=4; IntAct=EBI-776269, EBI-6095043; Membrane, clathrin-coated pit ; Peripheral membrane protein ; Cytoplasmic side Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q8VD37-1; Sequence=Displayed; Name=2; IsoId=Q8VD37-2; Sequence=VSP_020280, VSP_020282, VSP_020284; Name=3; IsoId=Q8VD37-3; Sequence=VSP_020279, VSP_020284, VSP_020285; Name=4; IsoId=Q8VD37-4; Sequence=VSP_020279, VSP_020284; Name=5; IsoId=Q8VD37-5; Sequence=VSP_020281, VSP_020283; Name=6; Synonyms=SGIP1alpha; IsoId=Q8VD37-6; Sequence=VSP_043987, VSP_020285; Name=7; IsoId=Q8VD37-8; Sequence=VSP_020285; Detected in brain, spinal cord and cerebellum. Up-regulated in the hypothalamus of obese mice. [Isoform 6]: The N-terminal domain (1-97) of this isoform mediates binding to and tubulation of membranes. response to dietary excess protein binding phospholipid binding cytoplasm cytoskeleton plasma membrane clathrin-coated pit endocytosis microtubule binding cytoskeletal protein binding tubulin binding membrane SH3 domain binding AP-2 adaptor complex clathrin-coated vesicle positive regulation of multicellular organism growth positive regulation of receptor-mediated endocytosis clathrin coat assembly clathrin-dependent endocytosis energy homeostasis plasma membrane tubulation presynapse positive regulation of eating behavior positive regulation of feeding behavior uc008twr.1 uc008twr.2 uc008twr.3 uc008twr.4 
ENSMUST00000066834.8 Klk13 ENSMUST00000066834.8 kallikrein related-peptidase 13 (from RefSeq NM_001039042.2) ENSMUST00000066834.1 ENSMUST00000066834.2 ENSMUST00000066834.3 ENSMUST00000066834.4 ENSMUST00000066834.5 ENSMUST00000066834.6 ENSMUST00000066834.7 Egfbp2 Klk13 Klnl NM_001039042 Q8CGR6 Q8CGR6_MOUSE uc009gnk.1 uc009gnk.2 uc009gnk.3 endopeptidase activity serine-type endopeptidase activity extracellular space cytoplasm proteolysis peptidase activity serine-type peptidase activity protein processing hydrolase activity secretory granule uc009gnk.1 uc009gnk.2 uc009gnk.3 
ENSMUST00000066849.13 Lef1 ENSMUST00000066849.13 lymphoid enhancer binding factor 1, transcript variant 5 (from RefSeq NM_001379060.1) D3Z654 D3Z654_MOUSE ENSMUST00000066849.1 ENSMUST00000066849.10 ENSMUST00000066849.11 ENSMUST00000066849.12 ENSMUST00000066849.2 ENSMUST00000066849.3 ENSMUST00000066849.4 ENSMUST00000066849.5 ENSMUST00000066849.6 ENSMUST00000066849.7 ENSMUST00000066849.8 ENSMUST00000066849.9 Lef1 NM_001379060 uc290jsv.1 uc290jsv.2 Nucleus Belongs to the TCF/LEF family. DNA binding nucleus regulation of transcription from RNA polymerase II promoter beta-catenin binding Wnt signaling pathway uc290jsv.1 uc290jsv.2 
ENSMUST00000066852.9 Ostn ENSMUST00000066852.9 osteocrin (from RefSeq NM_198112.2) ENSMUST00000066852.1 ENSMUST00000066852.2 ENSMUST00000066852.3 ENSMUST00000066852.4 ENSMUST00000066852.5 ENSMUST00000066852.6 ENSMUST00000066852.7 ENSMUST00000066852.8 NM_198112 OSTN_MOUSE Ostn P61364 Q149W1 uc007yvl.1 uc007yvl.2 uc007yvl.3 Hormone that acts as a ligand for natriuretic peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance in muscle. Acts as a regulator of osteoblast differentiation and bone growth by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (PubMed:14523025, PubMed:17951249). Required to enhance physical endurance: induced following physical exercise in muscle and promotes cGMP production, probably by interacting with NPR3/NPR-C (PubMed:26668395). May act as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (PubMed:15044443). Interacts with NPR3. Secreted Expressed in skeletal muscle and to a much lesser extent in bone, brown adipose tissue, spleen and testis (PubMed:14523025, PubMed:15044443, PubMed:26668395). Not expressed in neurons (PubMed:27830782). Expressed during matrix production and maturation. Also expressed during myocyte differentiation. Is regulated by nutritional changes (PubMed:15044443). Is up-regulated dose-dependently by insulin (PubMed:15044443). Is down- regulated dose-dependently by forskolin (PubMed:15044443). Induced in muscle following physical exercise (PubMed:26668395). Mice grow normally and do not display any visible phenotype but show reduced physical endurance (PubMed:26668395). Mice do not show skeletal deformities, differences in bone density, growth abnormalities, blood pressure nor body composition changes (PubMed:26668395). Belongs to the Osteocrin family. This protein-coding gene has been repurposed in primates, with the presence of a new enhancer sequence that drives expression in brain in response to sensory experience (PubMed:27830782). Name=Protein Spotlight; Note=Something else - Issue 189 of March 2017; URL="https://web.expasy.org/spotlight/back_issues/189/"; ossification endochondral bone growth receptor binding hormone activity extracellular region extracellular space cell surface receptor signaling pathway multicellular organism development hormone-mediated signaling pathway cell differentiation regulation of bone mineralization negative regulation of osteoblast differentiation negative regulation of glucose import negative regulation of dendrite extension uc007yvl.1 uc007yvl.2 uc007yvl.3 
ENSMUST00000066859.13 Cfh ENSMUST00000066859.13 Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. (from UniProt P06909) CFAH_MOUSE ENSMUST00000066859.1 ENSMUST00000066859.10 ENSMUST00000066859.11 ENSMUST00000066859.12 ENSMUST00000066859.2 ENSMUST00000066859.3 ENSMUST00000066859.4 ENSMUST00000066859.5 ENSMUST00000066859.6 ENSMUST00000066859.7 ENSMUST00000066859.8 ENSMUST00000066859.9 Hf1 M12660 P06909 Q6NZK3 uc287mgw.1 uc287mgw.2 Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. Homodimer. Forms also homooligomers. Interacts with complement protein C3b; this interaction inhibits complement activation. Interacts with complement protein C3d. Interacts with CR3/ITGAM; this interaction mediates adhesion of neutrophils to pathogens leading to pathogen clearance. Secreted CFH is one of the most abundant complement components in blood where the liver is the major source of CFH protein in vivo. in addition, CFH is secreted by additional cell types including monocytes, fibroblasts, or endothelial cells. Sushi 1-3 domain represents the minimal unit capable of cofactor activity. The property to discriminate self surfaces from non- self surfaces depends on the C-terminal region made of Sushis 19-20. Sulfated on tyrosine residues. Two codominant alleles of factor H are present in mice. The lack of CFH alters the microarchitecture of bone and affects osteoblast and osteoclast dynamics. complement component C3b binding immune system process protein binding extracellular region extracellular space nucleus cytoplasm plasma membrane complement activation complement activation, alternative pathway heparin binding regulation of complement activation heparan sulfate proteoglycan binding innate immune response positive regulation of cytolysis regulation of complement-dependent cytotoxicity uc287mgw.1 uc287mgw.2 
ENSMUST00000066863.13 Pfkfb2 ENSMUST00000066863.13 Synthesis and degradation of fructose 2,6-bisphosphate. (from UniProt Q6GTL7) BC051014 ENSMUST00000066863.1 ENSMUST00000066863.10 ENSMUST00000066863.11 ENSMUST00000066863.12 ENSMUST00000066863.2 ENSMUST00000066863.3 ENSMUST00000066863.4 ENSMUST00000066863.5 ENSMUST00000066863.6 ENSMUST00000066863.7 ENSMUST00000066863.8 ENSMUST00000066863.9 Pfkfb2 Q6GTL7 Q6GTL7_MOUSE uc287lne.1 uc287lne.2 Synthesis and degradation of fructose 2,6-bisphosphate. In the C-terminal section; belongs to the phosphoglycerate mutase family. catalytic activity 6-phosphofructo-2-kinase activity ATP binding fructose metabolic process fructose 2,6-bisphosphate metabolic process kinase activity phosphorylation carbohydrate phosphorylation uc287lne.1 uc287lne.2 
ENSMUST00000066873.5 Pkp3 ENSMUST00000066873.5 plakophilin 3, transcript variant 1 (from RefSeq NM_019762.2) A4QPD8 ENSMUST00000066873.1 ENSMUST00000066873.2 ENSMUST00000066873.3 ENSMUST00000066873.4 NM_019762 PKP3_MOUSE Q0VGP3 Q3KQL7 Q9QY23 uc009kji.1 uc009kji.2 uc009kji.3 uc009kji.4 May play a role in junctional plaques. Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QY23-1; Sequence=Displayed; Name=2; IsoId=Q9QY23-2; Sequence=VSP_026139; Belongs to the beta-catenin family. desmosome assembly protein binding nucleus nucleoplasm cytoplasm plasma membrane cell-cell junction cell-cell adherens junction spot adherens junction cell-cell junction assembly cell adhesion positive regulation of gene expression enzyme binding cell junction desmosome alpha-catenin binding cadherin binding cell adhesion molecule binding protein localization to plasma membrane cell-cell adhesion negative regulation of mRNA catabolic process messenger ribonucleoprotein complex uc009kji.1 uc009kji.2 uc009kji.3 uc009kji.4 
ENSMUST00000066875.9 6030452D12Rik ENSMUST00000066875.9 6030452D12Rik (from geneSymbol) AK031558 ENSMUST00000066875.1 ENSMUST00000066875.2 ENSMUST00000066875.3 ENSMUST00000066875.4 ENSMUST00000066875.5 ENSMUST00000066875.6 ENSMUST00000066875.7 ENSMUST00000066875.8 uc292czp.1 uc292czp.2 uc292czp.3 uc292czp.1 uc292czp.2 uc292czp.3 
ENSMUST00000066880.6 Capn12 ENSMUST00000066880.6 calpain 12 (from RefSeq NM_001110807.1) Capn12 E9QL26 E9QL26_MOUSE ENSMUST00000066880.1 ENSMUST00000066880.2 ENSMUST00000066880.3 ENSMUST00000066880.4 ENSMUST00000066880.5 NM_001110807 uc012fgy.1 uc012fgy.2 uc012fgy.3 Belongs to the peptidase C2 family. calcium-dependent cysteine-type endopeptidase activity calcium ion binding proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity uc012fgy.1 uc012fgy.2 uc012fgy.3 
ENSMUST00000066882.10 Pfn2 ENSMUST00000066882.10 profilin 2 (from RefSeq NM_019410.3) ENSMUST00000066882.1 ENSMUST00000066882.2 ENSMUST00000066882.3 ENSMUST00000066882.4 ENSMUST00000066882.5 ENSMUST00000066882.6 ENSMUST00000066882.7 ENSMUST00000066882.8 ENSMUST00000066882.9 NM_019410 PROF2_MOUSE Q3TPT7 Q3V171 Q9ES48 Q9ES49 Q9ES50 Q9JJV2 uc008phn.1 uc008phn.2 uc008phn.3 uc008phn.4 Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio (By similarity). Interacts with PFN2 (PubMed:19403918). [Isoform 1]: Interacts with ACTMAP (via N-terminus); the interaction may facilitate efficient cleavage of the acetylated N- terminus of immature actin by ACTMAP. [Isoform 2]: Interacts with ACTMAP (via N-terminus); the interaction may facilitate efficient cleavage of the acetylated N- terminus of immature actin by ACTMAP. Q9JJV2-1; P39053: Dnm1; NbExp=2; IntAct=EBI-990256, EBI-397785; Cytoplasm, cytoskeleton. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=IIa; IsoId=Q9JJV2-1; Sequence=Displayed; Name=2; Synonyms=IIb; IsoId=Q9JJV2-2; Sequence=VSP_005218; Name=3; IsoId=Q9JJV2-3; Sequence=VSP_024736; Isoform IIa is the main isoform and is abundant in brain. Isoform IIb is a minor isoform. Belongs to the profilin family. actin binding actin monomer binding protein binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm cytosol cytoskeleton negative regulation of epithelial cell migration ATPase activity actin cytoskeleton organization regulation of actin filament polymerization negative regulation of actin filament polymerization positive regulation of actin filament polymerization positive regulation of actin filament bundle assembly positive regulation of ATPase activity positive regulation of peptidyl-serine phosphorylation terminal bouton protein stabilization positive regulation of stress fiber assembly presynapse postsynapse modification of postsynaptic actin cytoskeleton glutamatergic synapse negative regulation of ruffle assembly regulation of synaptic vesicle exocytosis uc008phn.1 uc008phn.2 uc008phn.3 uc008phn.4 
ENSMUST00000066888.10 Utp18 ENSMUST00000066888.10 UTP18 small subunit processome component (from RefSeq NM_001013375.1) ENSMUST00000066888.1 ENSMUST00000066888.2 ENSMUST00000066888.3 ENSMUST00000066888.4 ENSMUST00000066888.5 ENSMUST00000066888.6 ENSMUST00000066888.7 ENSMUST00000066888.8 ENSMUST00000066888.9 NM_001013375 Q5SSI6 UTP18_MOUSE Wdr50 uc007kxk.1 uc007kxk.2 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus Belongs to the WD repeat UTP18 family. nucleus nucleolus rRNA processing nuclear membrane small-subunit processome Pwp2p-containing subcomplex of 90S preribosome uc007kxk.1 uc007kxk.2 
ENSMUST00000066905.9 Chl1 ENSMUST00000066905.9 cell adhesion molecule L1-like (from RefSeq NM_007697.2) A2RRK1 Call ENSMUST00000066905.1 ENSMUST00000066905.2 ENSMUST00000066905.3 ENSMUST00000066905.4 ENSMUST00000066905.5 ENSMUST00000066905.6 ENSMUST00000066905.7 ENSMUST00000066905.8 NCHL1_MOUSE NM_007697 P70232 Q8BS24 Q8C6W0 Q8C823 Q8VBY7 uc009dcj.1 uc009dcj.2 uc009dcj.3 Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons as well as in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane. May interact with L1CAM. May interact with ITGB1/ITGA1 heterodimer and ITGB1/ITGA2 heterodimer as well as with ANK3. P70232; Q9JMB8: Cntn6; NbExp=5; IntAct=EBI-7703109, EBI-7703151; P70232; P18052: Ptpra; NbExp=4; IntAct=EBI-7703109, EBI-6597520; Cell membrane; Single-pass type I membrane protein. Note=Soluble forms produced by cleavage/shedding also exist. [Processed neural cell adhesion molecule L1-like protein]: Secreted, extracellular space, extracellular matrix. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70232-1; Sequence=Displayed; Name=2; IsoId=P70232-2; Sequence=VSP_020083, VSP_020084, VSP_020085; Expressed in the brain, in the cerebellum and in the spinal cord. Detected in the retina and the optic nerve. Expressed in neurons and glial cells in the central nervous system and by Schwann cells in the peripheral nervous system. Not detectable in the forebrain at 11 dpc, weakly detectable at 13 dpc with highest detection at 18 dpc to postnatal day 7. Down-regulated at postnatal day 15 and further reduced in four-week- old animals. The FIG[AQ]Y motif seems to be an ankyrin recruitment region. The DGEA motif seems to be a recognition site for integrin. Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors. In brain extracts, these two soluble forms are also present and are dramatically reduced in mice lacking ADAM8 (PubMed:14761956). Cleaved by BACE1 (PubMed:29325091). N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc). O-glycosylated. Mice exhibit misguided axonal projections and aberrant axonal connectivity. They show alterations of hippocampal fiber organization and olfactory axon projections. Their exploratory behavior in novel environments is altered suggesting deficits in information processing and in attention. They also display signs of decreased stress and are more sociable and less aggressive. Heterozygous mice exhibit half levels of CHL1 expression in the hippocampus compared to their wild-type littermates, reflecting a gene dosage effect. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. Sequence=BAC30699.1; Type=Frameshift; Evidence=; neuron migration protease binding protein binding extracellular region plasma membrane cell adhesion multicellular organism development nervous system development axon guidance adult locomotory behavior membrane integral component of membrane sarcomere cell differentiation dendrite neuron projection development exploration behavior negative regulation of neuron apoptotic process apical part of cell cognition homophilic cell adhesion via plasma membrane adhesion molecules uc009dcj.1 uc009dcj.2 uc009dcj.3 
ENSMUST00000066921.10 Slc25a40 ENSMUST00000066921.10 solute carrier family 25, member 40, transcript variant 1 (from RefSeq NM_178766.5) ENSMUST00000066921.1 ENSMUST00000066921.2 ENSMUST00000066921.3 ENSMUST00000066921.4 ENSMUST00000066921.5 ENSMUST00000066921.6 ENSMUST00000066921.7 ENSMUST00000066921.8 ENSMUST00000066921.9 NM_178766 Q3UVZ5 Q8BGP6 Q8BXT8 S2540_MOUSE Slc25a40 uc008wkf.1 uc008wkf.2 uc008wkf.3 uc008wkf.4 uc008wkf.5 Probable mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron- sulfur clusters, as well as erythropoiesis (PubMed:34707288). Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGP6-1; Sequence=Displayed; Name=2; IsoId=Q8BGP6-2; Sequence=VSP_026243; Cells lacking both Slc25a39 and Slc25a40 show defects in the activity and stability of proteins containing iron- sulfur clusters. Belongs to the mitochondrial carrier (TC 2.A.29) family. mitochondrion mitochondrial inner membrane membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008wkf.1 uc008wkf.2 uc008wkf.3 uc008wkf.4 uc008wkf.5 
ENSMUST00000066936.9 Gpsm1 ENSMUST00000066936.9 G-protein signalling modulator 1 (AGS3-like, C. elegans), transcript variant 1 (from RefSeq NM_153410.5) A2AIX7 A2AIX8 A2AIX9 Ags3 C10a ENSMUST00000066936.1 ENSMUST00000066936.2 ENSMUST00000066936.3 ENSMUST00000066936.4 ENSMUST00000066936.5 ENSMUST00000066936.6 ENSMUST00000066936.7 ENSMUST00000066936.8 GPSM1_MOUSE NM_153410 Q61366 Q6IR34 Q8BUK4 Q8BX78 Q8R0R9 uc008iun.1 uc008iun.2 uc008iun.3 uc008iun.4 Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein- coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Interacts with GNAI1 and GNAI2 preferentially in their GDP- bound state. May also interact with GNAO1. Interacts with INSC/inscuteable and FRMPD1 (By similarity). Interacts with GNAI3. Interacts with STK11/LKB1 and MACF1. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q6IR34-1; Sequence=Displayed; Name=2; IsoId=Q6IR34-2; Sequence=VSP_039033; Name=3; IsoId=Q6IR34-3; Sequence=VSP_039029; Name=4; IsoId=Q6IR34-4; Sequence=VSP_039030, VSP_039031, VSP_039032; Name=5; IsoId=Q6IR34-5; Sequence=VSP_039030; Expressed in neural progenitor cells (at protein level). Expressed in brain at 14 dpc. The GoLoco domains are essential for the GDI activity toward G(i/o) alpha. The GoLoco domains mediate interaction with G(i/o) alpha (By similarity). Phosphorylation regulates interaction with G(i/o) alpha. Belongs to the GPSM family. Sequence=AAH26486.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH71197.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi membrane G-protein alpha-subunit binding GDP-dissociation inhibitor activity protein binding nucleoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol plasma membrane multicellular organism development nervous system development regulation of G-protein coupled receptor protein signaling pathway membrane positive regulation of macroautophagy cell differentiation GTPase regulator activity macromolecular complex negative regulation of GTPase activity negative regulation of guanyl-nucleotide exchange factor activity cell cortex uc008iun.1 uc008iun.2 uc008iun.3 uc008iun.4 
ENSMUST00000066949.9 Zdhhc25 ENSMUST00000066949.9 zinc finger, DHHC domain containing 25 (from RefSeq NM_027306.3) ENSMUST00000066949.1 ENSMUST00000066949.2 ENSMUST00000066949.3 ENSMUST00000066949.4 ENSMUST00000066949.5 ENSMUST00000066949.6 ENSMUST00000066949.7 ENSMUST00000066949.8 NM_027306 Q810M4 Q810M4_MOUSE Zdhhc25 uc007xeh.1 uc007xeh.2 uc007xeh.3 Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Membrane ; Multi- pass membrane protein The DHHC domain is required for palmitoyltransferase activity. Belongs to the DHHC palmitoyltransferase family. endoplasmic reticulum Golgi apparatus protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein-cysteine S-palmitoyltransferase activity uc007xeh.1 uc007xeh.2 uc007xeh.3 
ENSMUST00000066954.2 E130116L18Rik ENSMUST00000066954.2 E130116L18Rik (from geneSymbol) E130116L18Rik ENSMUST00000066954.1 Q8BMV6 Q8BMV6_MOUSE uc290ttu.1 uc290ttu.2 molecular_function cellular_component biological_process uc290ttu.1 uc290ttu.2 
ENSMUST00000066983.13 Abhd10 ENSMUST00000066983.13 abhydrolase domain containing 10, transcript variant 7 (from RefSeq NR_169117.1) ABHDA_MOUSE Abhd10 ENSMUST00000066983.1 ENSMUST00000066983.10 ENSMUST00000066983.11 ENSMUST00000066983.12 ENSMUST00000066983.2 ENSMUST00000066983.3 ENSMUST00000066983.4 ENSMUST00000066983.5 ENSMUST00000066983.6 ENSMUST00000066983.7 ENSMUST00000066983.8 ENSMUST00000066983.9 NR_169117 Q3TMB4 Q6PE15 Q8C3S8 Q8C724 Q8K188 uc007ziy.1 uc007ziy.2 uc007ziy.3 uc007ziy.4 This gene encodes a mitochondrially-localized enzyme that acts as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There are two pseudogenes for this gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.3523296.1, FO715707.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 21078990; reported by MitoCarta ##RefSeq-Attributes-END## Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins (PubMed:31740833). Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability (PubMed:31740833). Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate (By similarity). Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; EC=3.1.2.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19234; Evidence=; Reaction=H2O + mycophenolic acid O-acyl-beta-D-glucuronide = D- glucuronate + H(+) + mycophenolate; Xref=Rhea:RHEA:34179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58720, ChEBI:CHEBI:62932, ChEBI:CHEBI:66982; EC=3.1.1.93; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:34180; Evidence=; Inhibited by palmostatin-B. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PE15-1; Sequence=Displayed; Name=2; IsoId=Q6PE15-2; Sequence=VSP_023893, VSP_023894; Belongs to the AB hydrolase superfamily. hydrolase activity, hydrolyzing O-glycosyl compounds mitochondrion cytosol hydrolase activity glucuronoside catabolic process mycophenolic acid acyl-glucuronide esterase activity uc007ziy.1 uc007ziy.2 uc007ziy.3 uc007ziy.4 
ENSMUST00000066984.14 Gtf2h2 ENSMUST00000066984.14 general transcription factor II H, polypeptide 2, transcript variant 1 (from RefSeq NM_022011.4) Btf2p44 ENSMUST00000066984.1 ENSMUST00000066984.10 ENSMUST00000066984.11 ENSMUST00000066984.12 ENSMUST00000066984.13 ENSMUST00000066984.2 ENSMUST00000066984.3 ENSMUST00000066984.4 ENSMUST00000066984.5 ENSMUST00000066984.6 ENSMUST00000066984.7 ENSMUST00000066984.8 ENSMUST00000066984.9 NM_022011 Q9JIB4 TF2H2_MOUSE uc007rqv.1 uc007rqv.2 uc007rqv.3 uc007rqv.4 Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. Component of the TFIID-containing RNA polymerase II pre- initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2 and ERCC3. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with XPB, XPD, GTF2H1 and GTF2H3. Nucleus Belongs to the GTF2H2 family. core TFIIH complex portion of holo TFIIH complex core TFIIH complex G-protein coupled receptor internalization nucleic acid binding nucleus transcription factor TFIID complex holo TFIIH complex DNA repair nucleotide-excision repair transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein phosphorylation cellular response to DNA damage stimulus zinc ion binding obsolete general RNA polymerase II transcription factor activity nuclear speck metal ion binding protein N-terminus binding positive regulation of DNA helicase activity protein kinase activity DNA-dependent ATPase activity RNA polymerase II carboxy-terminal domain kinase activity uc007rqv.1 uc007rqv.2 uc007rqv.3 uc007rqv.4 
ENSMUST00000066987.14 Galnt10 ENSMUST00000066987.14 polypeptide N-acetylgalactosaminyltransferase 10 (from RefSeq NM_134189.2) ENSMUST00000066987.1 ENSMUST00000066987.10 ENSMUST00000066987.11 ENSMUST00000066987.12 ENSMUST00000066987.13 ENSMUST00000066987.2 ENSMUST00000066987.3 ENSMUST00000066987.4 ENSMUST00000066987.5 ENSMUST00000066987.6 ENSMUST00000066987.7 ENSMUST00000066987.8 ENSMUST00000066987.9 GLT10_MOUSE NM_134189 Q6KAQ2 Q6P9S7 Q8BZU8 Q91YJ6 uc007jab.1 uc007jab.2 uc007jab.3 uc007jab.4 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates (By similarity). Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Expressed at higher level than GALNT9. In the developing hindbrain region of 14.5 dpc embryos it accumulates in the rapidly dividing, undifferentiated ventricular zone adjacent to the pons. It also accumulates in the regions immediately rostral and caudal to the dorsal rhombic lips differentiating into the cerebellum. Not expressed in the developing choroid plexus. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. According to experiments made in rat, this enzyme is unable to transfer GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties, thereby acting as a glycopeptide transferase. Sequence=AAH16585.1; Type=Erroneous initiation; Evidence=; Sequence=BAD21405.1; Type=Erroneous initiation; Evidence=; Name=Functional Glycomics Gateway - GTase; Note=Polypeptide N-acetylgalactosaminyltransferase 10; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_518"; Golgi membrane polypeptide N-acetylgalactosaminyltransferase activity Golgi apparatus protein glycosylation protein O-linked glycosylation membrane integral component of membrane O-glycan processing transferase activity transferase activity, transferring glycosyl groups carbohydrate binding metal ion binding uc007jab.1 uc007jab.2 uc007jab.3 uc007jab.4 
ENSMUST00000066991.7 Adm2 ENSMUST00000066991.7 adrenomedullin 2 (from RefSeq NM_182928.5) ADM2_MOUSE Am2 ENSMUST00000066991.1 ENSMUST00000066991.2 ENSMUST00000066991.3 ENSMUST00000066991.4 ENSMUST00000066991.5 ENSMUST00000066991.6 NM_182928 Q4VAE1 Q7TNK8 uc007xgb.1 uc007xgb.2 uc007xgb.3 uc007xgb.4 uc007xgb.5 This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. Intravenous injection of the active peptide was found to protect mouse lungs from ischemia/reperfusion injury. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC096428.1, AB121035.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## [Adrenomedullin-2]: May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. [Intermedin-short]: May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. Secreted. High expression detected in the submaxillary gland, kidney, stomach, and mesentery, followed by the pituitary, lung, pancreas, intestines, spleen, thymus and ovary. Expressed mainly in the intermediate lobe of the pituitary, with sporadic in the anterior lobe. Belongs to the adrenomedullin family. angiogenesis hormone activity extracellular region protein phosphorylation adenylate cyclase-activating G-protein coupled receptor signaling pathway digestion feeding behavior positive regulation of gene expression macromolecular complex binding positive regulation of angiogenesis negative regulation of blood pressure uc007xgb.1 uc007xgb.2 uc007xgb.3 uc007xgb.4 uc007xgb.5 
ENSMUST00000066994.7 Zfp395 ENSMUST00000066994.7 zinc finger protein 395 (from RefSeq NM_199029.2) E9Q5N9 E9Q5N9_MOUSE ENSMUST00000066994.1 ENSMUST00000066994.2 ENSMUST00000066994.3 ENSMUST00000066994.4 ENSMUST00000066994.5 ENSMUST00000066994.6 NM_199029 Zfp395 uc007ujg.1 uc007ujg.2 uc007ujg.3 Nucleus RNA polymerase II core promoter proximal region sequence-specific DNA binding enhancer sequence-specific DNA binding nucleic acid binding DNA binding nucleus cytoplasm cytosol regulation of transcription from RNA polymerase II promoter uc007ujg.1 uc007ujg.2 uc007ujg.3 
ENSMUST00000067020.3 Nkx2-4 ENSMUST00000067020.3 NK2 homeobox 4 (from RefSeq NM_023504.1) A2ATK2 ENSMUST00000067020.1 ENSMUST00000067020.2 NKX24_MOUSE NM_023504 Nkx2d Q9EQM3 Q9EQM4 uc008mss.1 uc008mss.2 uc008mss.3 Probable transcription factor. Nucleus In the embryo it is detected in the posterior hypothalamus and later in the head. In the adult it is detected only in testis. Expressed in a restricted region of the posterior hypothalamus from 10 dpc. Detected in the head region from 12.5 dpc to 14.5 dpc. Expression is down-regulated by 15.5 dpc. Belongs to the NK-2 homeobox family. RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc008mss.1 uc008mss.2 uc008mss.3 
ENSMUST00000067036.12 Bsg ENSMUST00000067036.12 basigin, transcript variant 1 (from RefSeq NM_009768.2) BASI_MOUSE ENSMUST00000067036.1 ENSMUST00000067036.10 ENSMUST00000067036.11 ENSMUST00000067036.2 ENSMUST00000067036.3 ENSMUST00000067036.4 ENSMUST00000067036.5 ENSMUST00000067036.6 ENSMUST00000067036.7 ENSMUST00000067036.8 ENSMUST00000067036.9 NM_009768 P18572 Q6LDB0 Q7TSC0 uc007fzl.1 uc007fzl.2 uc007fzl.3 [Isoform 1]: Essential for normal retinal maturation and development (PubMed:10967074, PubMed:11273674, PubMed:11853760). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity). Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane (PubMed:12601063). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity). Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids (PubMed:23727514, PubMed:11882021). [Isoform 1]: Interacts with NXNL1 (PubMed:25957687). Interacts with SLC2A1 and SLC16A1/GLUT1 (By similarity). Interacts with XKR8; promoting its localization at the cell membrane (PubMed:27503893). [Isoform 2]: Interacts with ATP1B2, MAG and L1CAM (PubMed:12558975). Interacts with SLC16A7 (PubMed:21792931). Interacts with VEGFA, KDR/VEGFR2, PPIA/CYPA, SLC1A3, SLC16A11 and SLC16A12 (By similarity). Interacts with PPIL2; regulates BSG transport to the cell membrane (By similarity). Interacts with SLC16A1; interaction mediates SLC16A1 targeting to the plasma membrane (By similarity). Interacts with SLC16A3; interaction mediates SLC16A3 targeting to the plasma membrane (By similarity). Interacts with SLC16A6; this interaction mediates targeting to the plasma membrane. P18572; Q8BIL5: Hook1; NbExp=2; IntAct=EBI-772883, EBI-4285715; [Isoform 1]: Cell membrane ; Single-pass type I membrane protein Photoreceptor inner segment ll projection, cilium, photoreceptor outer segment [Isoform 2]: Cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Basolateral cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=5A11/Basigin asigin-1 ; IsoId=P18572-1; Sequence=Displayed; Name=2; Synonyms=5A11/Basigin-2 , Basigin-2 ; IsoId=P18572-2; Sequence=VSP_011502; [Isoform 1]: Retina-specific (PubMed:12939332, PubMed:11273674, PubMed:11853760, PubMed:25957687). Expressed in both rods and cones (at protein level) (PubMed:25957687). [Isoform 2]: Testis and caput, corpus and cauda epididymides (at protein level) (PubMed:11882021, PubMed:23727514, PubMed:21792931). Expressed in the brain, lung, liver, kidney, heart, spleen, uterus, retina and skeletal muscle (PubMed:2361961, PubMed:12939332, PubMed:12601063). In developing eye expressed at embryonic days 12 dpc, 15 dpc and 18 dpc, and at postnatal days P1, P7, P14, and P21. Expression progressed from a more generalized distribution throughout the undifferentiated neural retina to specific staining of retina- pigmented epithilia, the MCs, photoreceptor cells and the ciliary apparatus. Expression is highest at P21. Isoform 1 and isoform 2 are expressed at equivalent levels at P7, isoform 1 is more abundant at P14, P21 and P28. In uterus during the peri-implantation period strongly expressed in luminal and glandular epithelium on day 1 of pregnancy and gradually decreased to a basal level from day 2-4 of pregnancy. Expression in the sub-luminal stroma was first detected on day 3 of pregnancy and increased on day 4 of pregnancy. On day 5 of pregnancy, the expression of basigin protein and mRNA was only detected in the implanting embryos, and the luminal epithelium and sub-luminal stroma surrounding the embryos. In ovary during sexual maturation expressed in the granulosa cells of preantral follicles at days 20 and 25 after birth. Expressed during corpus luteum formation. By estrogen in the uterine epithelium of ovariectomized animals. By eCG in ovary. [Isoform 1]: N-glycosylated. [Isoform 2]: N-glycosylated (PubMed:12558975, PubMed:23727514). During spermatogenesis, probably deglycosylated during epididymal transit (PubMed:11882021). Male mice are sterile, testis lack elongated spermatids and mature spermatozoa, spermatogenesis is arrested at the early round spermatid stages before any spermatid differentiation occurrs and a large increase in the number of germ cells undergoing apoptosis is seen in the testis (PubMed:23727514). Mice are visually impaired at the time of eye opening (2 weeks of age), despite normal retina architecture at that age (PubMed:10967074, PubMed:11273674, PubMed:11853760). At visual maturity (3 weeks of age), the photoreceptor outer segments appear less dense and shorter than those of control animals, and at 8 weeks, retinal degeneration is observed (PubMed:10967074, PubMed:11273674, PubMed:11853760). acrosomal membrane protein binding mannose binding mitochondrion plasma membrane integral component of plasma membrane homophilic cell adhesion via plasma membrane adhesion molecules axon guidance embryo implantation membrane integral component of membrane carbohydrate binding axon sarcolemma melanosome odontogenesis of dentin-containing tooth intracellular membrane-bounded organelle response to peptide hormone membrane raft response to mercury ion decidualization response to cAMP dendrite self-avoidance protein localization to plasma membrane protein binding involved in cell-cell adhesion uc007fzl.1 uc007fzl.2 uc007fzl.3 
ENSMUST00000067043.5 Zbtb26 ENSMUST00000067043.5 zinc finger and BTB domain containing 26 (from RefSeq NM_199025.3) ENSMUST00000067043.1 ENSMUST00000067043.2 ENSMUST00000067043.3 ENSMUST00000067043.4 NM_199025 Q6P9Q3 Q6P9Q3_MOUSE Zbtb26 uc008jmv.1 uc008jmv.2 negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus identical protein binding uc008jmv.1 uc008jmv.2 
ENSMUST00000067048.8 Dnah5 ENSMUST00000067048.8 dynein, axonemal, heavy chain 5 (from RefSeq NM_133365.3) DYH5_MOUSE Dnah5 Dnahc5 E9QKD7 ENSMUST00000067048.1 ENSMUST00000067048.2 ENSMUST00000067048.3 ENSMUST00000067048.4 ENSMUST00000067048.5 ENSMUST00000067048.6 ENSMUST00000067048.7 NM_133365 Q8BWG1 Q8VHE6 uc007vjy.1 uc007vjy.2 uc007vjy.3 Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. Interacts with DNAL1 (By similarity). Consists of at least two heavy chains and a number of intermediate and light chains. Cytoplasm, cytoskeleton, cilium axoneme Strongly expressed in lung and kidney and weaker expression seen in brain, heart and testis. In the brain, expressed in ependymal cells lining the brain ventricles and the aqueduct. Embryos show a weak expression confined to the node from 7.0 to 8.25 dpc. Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function. Note=Defects in Dnah5 are the cause of primary ciliary dyskinesia (PCD). PCD is characterized by recurrent respiratory infections, situs inversus and ciliary immotility and hydrocephalus. Mice display defects in motility of the ependymal cells lining the brain ventricles and aqueduct. This results in impaired flow of cerebrospinal fluid through the cerebral aqueduct and gives rise to closure of the aqueduct and subsequent formation of triventricular hydrocephalus during early postnatal brain development. Belongs to the dynein heavy chain family. nucleotide binding cilium movement epithelial cilium movement motor activity microtubule motor activity ATP binding extracellular region cytoplasm cytoskeleton axonemal dynein complex microtubule cilium axoneme microtubule-based movement determination of left/right symmetry heart development ATP-dependent microtubule motor activity, minus-end-directed lateral ventricle development dynein complex flagellated sperm motility outer dynein arm outer dynein arm assembly cell projection dynein intermediate chain binding dynein light intermediate chain binding cilium assembly 9+2 motile cilium uc007vjy.1 uc007vjy.2 uc007vjy.3 
ENSMUST00000067058.3 Pigw ENSMUST00000067058.3 phosphatidylinositol glycan anchor biosynthesis, class W, transcript variant 1 (from RefSeq NM_027388.2) ENSMUST00000067058.1 ENSMUST00000067058.2 NM_027388 PIGW_MOUSE Pigw Q8C398 Q8C4S0 Q9CSX1 uc007kqy.1 uc007kqy.2 uc007kqy.3 Required for the transport of GPI-anchored proteins to the plasma membrane. Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI- anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins. Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the PIGW family. Sequence=BAC38199.1; Type=Frameshift; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups glucosaminyl-phosphotidylinositol O-acyltransferase activity protein localization to plasma membrane uc007kqy.1 uc007kqy.2 uc007kqy.3 
ENSMUST00000067060.10 Klf1 ENSMUST00000067060.10 Kruppel-like transcription factor 1 (erythroid) (from RefSeq NM_010635.3) E9QNP6 E9QNP6_MOUSE ENSMUST00000067060.1 ENSMUST00000067060.2 ENSMUST00000067060.3 ENSMUST00000067060.4 ENSMUST00000067060.5 ENSMUST00000067060.6 ENSMUST00000067060.7 ENSMUST00000067060.8 ENSMUST00000067060.9 Klf1 NM_010635 uc009mnz.1 uc009mnz.2 uc009mnz.3 uc009mnz.4 Nucleus nuclear chromatin core promoter proximal region sequence-specific DNA binding nucleic acid binding nucleus nucleoplasm regulation of transcription, DNA-templated erythrocyte differentiation transcription regulatory region DNA binding positive regulation of transcription, DNA-templated maternal process involved in female pregnancy cellular response to peptide uc009mnz.1 uc009mnz.2 uc009mnz.3 uc009mnz.4 
ENSMUST00000067072.5 Cthrc1 ENSMUST00000067072.5 collagen triple helix repeat containing 1, transcript variant 1 (from RefSeq NM_026778.3) CTHR1_MOUSE ENSMUST00000067072.1 ENSMUST00000067072.2 ENSMUST00000067072.3 ENSMUST00000067072.4 NM_026778 Q3UAP6 Q9D1D6 uc007voa.1 uc007voa.2 uc007voa.3 May act as a negative regulator of collagen matrix deposition. Secreted, extracellular space, extracellular matrix N-glycosylated. frizzled binding protein binding extracellular region collagen trimer extracellular space cytoplasm cell migration Wnt-protein binding extracellular matrix positive regulation of protein binding positive regulation of osteoblast proliferation ossification involved in bone remodeling positive regulation of osteoblast differentiation Wnt signaling pathway, planar cell polarity pathway inner ear receptor stereocilium organization negative regulation of canonical Wnt signaling pathway cochlea morphogenesis establishment of planar polarity involved in neural tube closure uc007voa.1 uc007voa.2 uc007voa.3 
ENSMUST00000067075.7 Nkx2-2 ENSMUST00000067075.7 NK2 homeobox 2, transcript variant 1 (from RefSeq NM_010919.3) ENSMUST00000067075.1 ENSMUST00000067075.2 ENSMUST00000067075.3 ENSMUST00000067075.4 ENSMUST00000067075.5 ENSMUST00000067075.6 NM_010919 Nkx2-2 Q3URZ4 Q3URZ4_MOUSE uc008msu.1 uc008msu.2 uc008msu.3 Nucleus Belongs to the NK-2 homeobox family. DNA binding nucleus regulation of transcription, DNA-templated response to glucose response to organic cyclic compound optic nerve development response to progesterone sequence-specific DNA binding uc008msu.1 uc008msu.2 uc008msu.3 
ENSMUST00000067081.10 Cdk11b ENSMUST00000067081.10 cyclin dependent kinase 11B, transcript variant 1 (from RefSeq NM_007661.5) CD11B_MOUSE Cdc2l1 Cdk11 ENSMUST00000067081.1 ENSMUST00000067081.2 ENSMUST00000067081.3 ENSMUST00000067081.4 ENSMUST00000067081.5 ENSMUST00000067081.6 ENSMUST00000067081.7 ENSMUST00000067081.8 ENSMUST00000067081.9 NM_007661 P24788 Q3UI03 Q61399 Q7TST4 Q8BP53 uc008wea.1 uc008wea.2 uc008wea.3 Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity- dependent manner. May act as a negative regulator of normal cell cycle progression. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Phosphorylation at Thr-437 or Tyr-438 inactivates the enzyme, while phosphorylation at Thr-584 activates it. May interact PAK1 and RANBP9. p110C interacts with RNPS1. Interacts with CCND3. Interacts with CCNL1 and CCNL2. Forms complexes with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7. Event=Alternative initiation; Named isoforms=2; Name=1; Synonyms=p130PITSLRE; IsoId=P24788-1; Sequence=Displayed; Name=2; Synonyms=p58clk-1; IsoId=P24788-2; Sequence=VSP_018835; Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Sequence=AAA03518.1; Type=Frameshift; Evidence=; nucleotide binding blastocyst development protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus nucleoplasm protein phosphorylation cell cycle regulation of mitotic nuclear division kinase activity phosphorylation transferase activity regulation of mRNA processing negative regulation of apoptotic signaling pathway uc008wea.1 uc008wea.2 uc008wea.3 
ENSMUST00000067082.14 Pde8b ENSMUST00000067082.14 phosphodiesterase 8B, transcript variant 5 (from RefSeq NM_001374004.1) E9Q4S1 ENSMUST00000067082.1 ENSMUST00000067082.10 ENSMUST00000067082.11 ENSMUST00000067082.12 ENSMUST00000067082.13 ENSMUST00000067082.2 ENSMUST00000067082.3 ENSMUST00000067082.4 ENSMUST00000067082.5 ENSMUST00000067082.6 ENSMUST00000067082.7 ENSMUST00000067082.8 ENSMUST00000067082.9 NM_001374004 PDE8B_MOUSE uc288pgd.1 uc288pgd.2 Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland (By similarity). Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. Widely expressed. Detectable in the adrenal gland of newborn animals. Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. behavioral fear response 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cellular_component cAMP catabolic process signal transduction phosphoric diester hydrolase activity visual learning hydrolase activity operant conditioning negative regulation of insulin secretion metal ion binding neuromuscular process controlling balance negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of steroid hormone biosynthetic process uc288pgd.1 uc288pgd.2 
ENSMUST00000067085.7 Nepn ENSMUST00000067085.7 nephrocan (from RefSeq NM_025684.3) ENSMUST00000067085.1 ENSMUST00000067085.2 ENSMUST00000067085.3 ENSMUST00000067085.4 ENSMUST00000067085.5 ENSMUST00000067085.6 NEPN_MOUSE NM_025684 Nepn Q9CQ76 uc007fbh.1 uc007fbh.2 uc007fbh.3 May inhibit TGF-beta signaling. Secreted Expressed at highest levels in the kidney, where it is primarily detected in the epithelial cells of distal tubules and collecting ducts, and more weakly in proximal epithelial cells. Expressed at lower levels in heart and lung (at protein level). Detected in skeletal muscle. Detected in the definitive endoderm from 7.5 dpc onwards (PubMed:17683524). Strongly expressed in the developing midgut by 9 dpc, but then at 9.5 dpc expression appears to decrease (PubMed:17683524). Global expression levels peak during 11 dpc: also detected at slightly lower levels during 7 dpc, 15 dpc and 17 dpc (PubMed:16990280). N-glycosylated. Belongs to the small leucine-rich proteoglycan (SLRP) family. negative regulation of transcription from RNA polymerase II promoter molecular_function extracellular region interstitial matrix extracellular space extracellular matrix organization negative regulation of transforming growth factor beta receptor signaling pathway extracellular matrix uc007fbh.1 uc007fbh.2 uc007fbh.3 
ENSMUST00000067087.7 Alkal2 ENSMUST00000067087.7 ALK and LTK ligand 2, transcript variant 2 (from RefSeq NM_001377064.1) ALKL2_MOUSE Alkal2 ENSMUST00000067087.1 ENSMUST00000067087.2 ENSMUST00000067087.3 ENSMUST00000067087.4 ENSMUST00000067087.5 ENSMUST00000067087.6 Fam150b G3X9F3 NM_001377064 Q80UG6 uc007ngv.1 uc007ngv.2 uc007ngv.3 Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation. Cytokine- binding is sufficient to activate LTK. In contrast, ALKAL2-driven activation of ALK is coupled with heparin-binding to ALK. Stimulation of ALK signaling is involved in neural development and regulation of energy expenditure. Homodimer. Secreted Cell membrane Note=Following interaction with receptor tyrosine kinase ALK, associates with the cell membrane, membrane-binding is required to activate ALK. Belongs to the ALKAL family. Sequence=AAH46522.1; Type=Erroneous initiation; Evidence=; cellular_component extracellular region positive regulation of neuron projection development receptor signaling protein tyrosine kinase activator activity receptor tyrosine kinase binding positive regulation of protein tyrosine kinase activity positive regulation of ERK1 and ERK2 cascade positive regulation of ERK5 cascade uc007ngv.1 uc007ngv.2 uc007ngv.3 
ENSMUST00000067098.8 Ffar4 ENSMUST00000067098.8 free fatty acid receptor 4 (from RefSeq NM_181748.2) ENSMUST00000067098.1 ENSMUST00000067098.2 ENSMUST00000067098.3 ENSMUST00000067098.4 ENSMUST00000067098.5 ENSMUST00000067098.6 ENSMUST00000067098.7 FFAR4_MOUSE Gpr120 NM_181748 O3far1 Q7TMA4 uc008hjc.1 uc008hjc.2 uc008hjc.3 G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G-protein and beta-arrestin pathways (PubMed:27852822, PubMed:26873857). LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs) (PubMed:27852822, PubMed:26873857). After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed:27852822, PubMed:26873857). In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation (PubMed:17250804, PubMed:22343897, PubMed:27853148, PubMed:29343498, PubMed:31761534). Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry (PubMed:31761534). Induces differentiation of brown and beige adipocytes probably via autocrine and endocrine functions of FGF21 hormone (PubMed:27853148, PubMed:29343498). Contributes to the thermogenic activation of brown adipose tissue and the browning of white adipose tissue (PubMed:27853148, PubMed:29343498). Activates brown adipocytes by initiating intracellular calcium signaling leading to mitochondrial depolarization and fission, and overall increased mitochondrial respiration (PubMed:29343498). Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass (PubMed:29343498). Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins (PubMed:26365922). In response to dietary fats regulates hormone secretion and appetite (PubMed:15619630, PubMed:25535828, PubMed:24742677, PubMed:24663807, PubMed:24222669). Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG secretion in pancreatic alpha cells, thereby playing a role in the regulation of blood glucose levels (PubMed:15619630, PubMed:25535828, PubMed:24742677). Negatively regulates glucose-induced SST secretion in pancreatic delta cells (PubMed:24663807). Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone (PubMed:24222669). In taste buds, contributes to sensing of dietary fatty acids by the gustatory system (PubMed:20573884). During the inflammatory response, promotes anti-inflammatory M2 macrophage differentiation in adipose tissue (PubMed:20813258). Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation (By similarity). In this pathway, interacts with adapter protein ARRB2 and inhibits the priming step triggered by Toll-like receptors (TLRs) at the level of TAK1 and TAB1 (PubMed:20813258). Further inhibits the activation step when ARRB2 directly associates with NLRP3, leading to inhibition of pro-inflammatory cytokine release (By similarity). Mediates LCFAs anti-apoptotic effects (PubMed:15774482). Interacts (via C-terminus) with ARRB2 following LCFAs stimulation. Q7TMA4; Q91YI4: Arrb2; NbExp=4; IntAct=EBI-2912413, EBI-994161; Cell membrane ulti-pass membrane protein Endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Cell projection, cilium membrane ; Multi-pass membrane protein Note=Sorted to late endosome/lysosome compartments upon internalization (By similarity). Specifically localizes to the primary cilium of undifferentiated adipocytes. Ciliary trafficking is TULP3- dependent. As the cilium is lost during adipogenesis, moves to the plasma membrane (PubMed:31761534). Highly expressed in brown and white adipose tissue (PubMed:27853148, PubMed:17250804, PubMed:24222669). Expressed in perivascular ciliated preadipocytes (at protein level) (PubMed:31761534). Expressed in the taste buds of the circumvallate and fungiform papillae, mainly in type II cells (at protein level) (PubMed:19071193, PubMed:20573884). Abundant expression is detected in the gastrointestinal tract (PubMed:15619630, PubMed:27853148, PubMed:17250804, PubMed:24222669). Highly expressed in lung and pituitary gland (PubMed:15619630, PubMed:17250804). Expressed in enteroendocrine K cells of the upper small intestine (PubMed:25535828). Expressed in alpha and delta cells of pancreatic islets (PubMed:24742677, PubMed:24663807). Expressed in pro-inflammatory CD11C-positive macrophages (PubMed:20813258). Also expressed in spleen (PubMed:17250804). Expression detected in differentiated mature adipocytes, with levels increasing during late stage adipocyte differentiation (PubMed:17250804, PubMed:29343498). Low expression is detected in preadipocytes, mainly localized in primary cilium (PubMed:31761534). Expression level in bone marrow mesenchymal stem cells is gradually increased during differentiation toward osteoblasts (PubMed:26365922). Up-regulated in response to high-fat diet in adipose tissue macrophages and in hepatic Kupffer cells (PubMed:17250804, PubMed:20813258). Up-regulated in response to either short- or long- term cold exposure in brown adipose tissue and inguinal white adipose tissue (PubMed:27853148). Up-regulated by ADRB3 agonist (PubMed:29343498). Phosphorylated at two clusters of Ser and Thr residues located in the intracellular C-terminus, a prerequisite for FFAR4 internalization via an ARRB2-dependent pathway. Deficient mice show glucose intolerance, hyperinsulinemia and display insulin (INS) resistance and a reduced preference for fatty acids (PubMed:22343897, PubMed:24742677, PubMed:20573884). When fed a high-fat diet, they develop obesity and have fatty liver with decreased adipocyte differentiation and lipogenesis, and enhanced hepatic lipogenesis (PubMed:22343897). INS resistance in such mice is associated with reduced INS signaling and enhanced inflammation in adipose tissue (PubMed:20813258). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity fatty acid binding protein binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway lipid binding taste receptor activity regulation of glucose transport membrane integral component of membrane endocytic vesicle negative regulation of apoptotic process fat cell differentiation hormone secretion negative regulation of cytokine secretion negative regulation of inflammatory response detection of chemical stimulus involved in sensory perception of taste positive regulation of ERK1 and ERK2 cascade uc008hjc.1 uc008hjc.2 uc008hjc.3 
ENSMUST00000067101.10 Kcnj3 ENSMUST00000067101.10 potassium inwardly-rectifying channel, subfamily J, member 3, transcript variant 1 (from RefSeq NM_008426.2) ENSMUST00000067101.1 ENSMUST00000067101.2 ENSMUST00000067101.3 ENSMUST00000067101.4 ENSMUST00000067101.5 ENSMUST00000067101.6 ENSMUST00000067101.7 ENSMUST00000067101.8 ENSMUST00000067101.9 Kcnj3 NM_008426 Q3ZAT1 Q3ZAT1_MOUSE uc008jru.1 uc008jru.2 uc008jru.3 This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger. Membrane ulti-pass membrane protein Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily. inward rectifier potassium channel activity voltage-gated ion channel activity ion transport potassium ion transport voltage-gated potassium channel complex external side of plasma membrane cell surface G-protein activated inward rectifier potassium channel activity membrane integral component of membrane T-tubule regulation of ion transmembrane transport response to electrical stimulus potassium ion import across plasma membrane uc008jru.1 uc008jru.2 uc008jru.3 
ENSMUST00000067102.3 Sprr2k ENSMUST00000067102.3 small proline-rich protein 2K (from RefSeq NM_011477.3) ENSMUST00000067102.1 ENSMUST00000067102.2 G5E8D1 G5E8D1_MOUSE NM_011477 Sprr2k uc008qea.1 uc008qea.2 uc008qea.3 Belongs to the cornifin (SPRR) family. cornified envelope uc008qea.1 uc008qea.2 uc008qea.3 
ENSMUST00000067103.4 Taf8 ENSMUST00000067103.4 TATA-box binding protein associated factor 8, transcript variant 10 (from RefSeq NR_176963.1) ENSMUST00000067103.1 ENSMUST00000067103.2 ENSMUST00000067103.3 NR_176963 Q3TSE4 Q6PES8 Q8C382 Q8C664 Q8C7L7 Q9EQH4 TAF8_MOUSE Tbn uc008cvh.1 uc008cvh.2 uc008cvh.3 The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (By similarity). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (By similarity). TAF8 is involved in forming the TFIID-B module, together with TAF5 (By similarity). Mediates both basal and activator-dependent transcription (By similarity). Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349). Required for the integration of TAF10 in the TAF complex (By similarity). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (PubMed:11076765). Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP- associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TBP, TAF1, TAF6, TAF10, TAF11 and TAF13. Component also of a small TAF complex (SMAT) containing TAF8, TAF10 and SUPT7L. Forms a heterodimer with TAF10. Interaction with TAF10 is mediated mainly via its histone fold domain while interaction with SUPT7L is via its C-terminal region. Nucleus Cytoplasm Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9EQH4-1; Sequence=Displayed; Name=2; IsoId=Q9EQH4-2; Sequence=VSP_030555; Name=3; IsoId=Q9EQH4-3; Sequence=VSP_030553, VSP_030554; Name=4; IsoId=Q9EQH4-4; Sequence=VSP_030552; Name=5; IsoId=Q9EQH4-5; Sequence=VSP_030550, VSP_030551; Low level of expression throughout the brain with slightly higher expression in the hippocampus. Expressed ubiquitously at very low levels throughout embryonic development. Higher levels of expression seen in inner cell mass and heart. Death during early embryonic development. The inner cell mass cells of mutant embryos died of apoptosis. 'Taube nuss' means 'empty nut' in German. Belongs to the TAF8 family. inner cell mass cell proliferation protein binding nucleus nucleoplasm transcription factor TFIID complex cytoplasm multicellular organism development cell differentiation regulation of fat cell differentiation positive regulation of transcription, DNA-templated protein heterodimerization activity perinuclear region of cytoplasm maintenance of protein location in nucleus uc008cvh.1 uc008cvh.2 uc008cvh.3 
ENSMUST00000067120.14 Chrna4 ENSMUST00000067120.14 cholinergic receptor, nicotinic, alpha polypeptide 4, transcript variant 1 (from RefSeq NM_015730.6) Chrna4 ENSMUST00000067120.1 ENSMUST00000067120.10 ENSMUST00000067120.11 ENSMUST00000067120.12 ENSMUST00000067120.13 ENSMUST00000067120.2 ENSMUST00000067120.3 ENSMUST00000067120.4 ENSMUST00000067120.5 ENSMUST00000067120.6 ENSMUST00000067120.7 ENSMUST00000067120.8 ENSMUST00000067120.9 NM_015730 Q53YK0 Q53YK0_MOUSE uc008okq.1 uc008okq.2 uc008okq.3 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. Cell membrane ; Lipid-anchor Cell membrane ; Multi-pass membrane protein Membrane ; Lipid-anchor Membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub- subfamily. response to hypoxia transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane acetylcholine-gated channel complex DNA repair ion transport response to oxidative stress signal transduction synaptic transmission, cholinergic acetylcholine receptor activity membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction ion transmembrane transport response to nicotine behavioral response to nicotine synapse postsynaptic membrane neurological system process cognition regulation of postsynaptic membrane potential excitatory postsynaptic potential uc008okq.1 uc008okq.2 uc008okq.3 
ENSMUST00000067167.6 Fra10ac1 ENSMUST00000067167.6 FRA10A associated CGG repeat 1, transcript variant 1 (from RefSeq NM_001081075.2) ENSMUST00000067167.1 ENSMUST00000067167.2 ENSMUST00000067167.3 ENSMUST00000067167.4 ENSMUST00000067167.5 F10C1_MOUSE F8VPM5 NM_001081075 Q1LZ54 Q3T9W6 Q8BP78 uc008hjg.1 uc008hjg.2 uc008hjg.3 uc008hjg.4 May be involved in pre-mRNA splicing. Interacts with ESS2. Nucleus Sequence=AK017666; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAC36871.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component nucleus biological_process uc008hjg.1 uc008hjg.2 uc008hjg.3 uc008hjg.4 
ENSMUST00000067173.8 Tmem45a2 ENSMUST00000067173.8 transmembrane protein 45A2, transcript variant 2 (from RefSeq NM_183281.2) 2310005G13Rik B7ZWJ5 B7ZWJ5_MOUSE ENSMUST00000067173.1 ENSMUST00000067173.2 ENSMUST00000067173.3 ENSMUST00000067173.4 ENSMUST00000067173.5 ENSMUST00000067173.6 ENSMUST00000067173.7 NM_183281 Tmem45a2 uc007zmy.1 uc007zmy.2 uc007zmy.3 uc007zmy.4 Membrane ; Multi- pass membrane protein Belongs to the TMEM45 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007zmy.1 uc007zmy.2 uc007zmy.3 uc007zmy.4 
ENSMUST00000067190.12 Lifr ENSMUST00000067190.12 LIF receptor alpha, transcript variant 3 (from RefSeq NM_001358593.1) ENSMUST00000067190.1 ENSMUST00000067190.10 ENSMUST00000067190.11 ENSMUST00000067190.2 ENSMUST00000067190.3 ENSMUST00000067190.4 ENSMUST00000067190.5 ENSMUST00000067190.6 ENSMUST00000067190.7 ENSMUST00000067190.8 ENSMUST00000067190.9 LIFR_MOUSE NM_001358593 P42703 Q5I0Y2 uc007vdx.1 uc007vdx.2 uc007vdx.3 uc007vdx.4 Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR (By similarity). [Isoform 1]: Cell membrane; Single-pass type I membrane protein. [Isoform 2]: Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Membrane; IsoId=P42703-1; Sequence=Displayed; Name=2; Synonyms=Secreted; IsoId=P42703-2; Sequence=VSP_001686, VSP_001687; Placenta, liver, kidney, heart, lung, brain, and embryos. The liver may be the primary site of synthesis of the secreted form. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Belongs to the type I cytokine receptor family. Type 2 subfamily. cytokine receptor activity ciliary neurotrophic factor receptor activity leukemia inhibitory factor receptor activity oncostatin-M receptor activity ciliary neurotrophic factor receptor binding protein binding extracellular region extracellular space plasma membrane positive regulation of cell proliferation external side of plasma membrane negative regulation of muscle cell apoptotic process membrane integral component of membrane cytokine-mediated signaling pathway growth factor binding cytokine binding animal organ regeneration response to cytokine oncostatin-M-mediated signaling pathway receptor complex neuron projection morphogenesis leukemia inhibitory factor signaling pathway ciliary neurotrophic factor-mediated signaling pathway uc007vdx.1 uc007vdx.2 uc007vdx.3 uc007vdx.4 
ENSMUST00000067198.3 Serpinb9d ENSMUST00000067198.3 serine (or cysteine) peptidase inhibitor, clade B, member 9d (from RefSeq NM_011460.3) ENSMUST00000067198.1 ENSMUST00000067198.2 NM_011460 Q8BMT0 Q8BMT0_MOUSE Serpinb9d uc007qad.1 uc007qad.2 uc007qad.3 Belongs to the serpin family. Ov-serpin subfamily. serine-type endopeptidase inhibitor activity extracellular space cytoplasm negative regulation of endopeptidase activity uc007qad.1 uc007qad.2 uc007qad.3 
ENSMUST00000067210.12 Zscan4d ENSMUST00000067210.12 zinc finger and SCAN domain containing 4D (from RefSeq NM_001100186.1) A7KBS4 ENSMUST00000067210.1 ENSMUST00000067210.10 ENSMUST00000067210.11 ENSMUST00000067210.2 ENSMUST00000067210.3 ENSMUST00000067210.4 ENSMUST00000067210.5 ENSMUST00000067210.6 ENSMUST00000067210.7 ENSMUST00000067210.8 ENSMUST00000067210.9 NM_001100186 ZSC4D_MOUSE uc009fdm.1 uc009fdm.2 uc009fdm.3 Transcription factor required to regulate early development. Binds telomeres and plays a key role in genomic stability by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation (By similarity). Nucleus Chromosome, telomere Highly expressed at the 2-cell stage but its expression is rapidly turned off. chromosome, telomeric region nuclear chromosome, telomeric region nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus chromosome regulation of transcription, DNA-templated telomere maintenance via telomere lengthening metal ion binding uc009fdm.1 uc009fdm.2 uc009fdm.3 
ENSMUST00000067215.9 Arfgap3 ENSMUST00000067215.9 ADP-ribosylation factor GTPase activating protein 3, transcript variant 3 (from RefSeq NM_025445.4) A0A0R4J0T8 A0A0R4J0T8_MOUSE Arfgap3 ENSMUST00000067215.1 ENSMUST00000067215.2 ENSMUST00000067215.3 ENSMUST00000067215.4 ENSMUST00000067215.5 ENSMUST00000067215.6 ENSMUST00000067215.7 ENSMUST00000067215.8 NM_025445 uc007xag.1 uc007xag.2 uc007xag.3 GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side GTPase activator activity Golgi apparatus cytosol protein secretion positive regulation of GTPase activity metal ion binding uc007xag.1 uc007xag.2 uc007xag.3 
ENSMUST00000067218.14 Parp3 ENSMUST00000067218.14 poly (ADP-ribose) polymerase family, member 3, transcript variant 2 (from RefSeq NM_145619.3) A0A1L1SRP6 Adprt3 E9PX17 E9Q992 ENSMUST00000067218.1 ENSMUST00000067218.10 ENSMUST00000067218.11 ENSMUST00000067218.12 ENSMUST00000067218.13 ENSMUST00000067218.2 ENSMUST00000067218.3 ENSMUST00000067218.4 ENSMUST00000067218.5 ENSMUST00000067218.6 ENSMUST00000067218.7 ENSMUST00000067218.8 ENSMUST00000067218.9 NM_145619 PARP3_MOUSE Parp3 Q3UGL7 Q3ULW8 Q8BHN6 Q8BXU2 Q8CFB8 Q91YR6 uc009rjy.1 uc009rjy.2 uc009rjy.3 Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:21270334, PubMed:24598253). Mediates mono-ADP- ribosylation of glutamate, aspartate or lysine residues on target proteins (By similarity). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6 (By similarity). ADP- ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). Involved in single-strand break repair by catalyzing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA (By similarity). Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ (By similarity). Suppresses G-quadruplex (G4) structures in response to DNA damage (By similarity). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (By similarity). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (By similarity). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (PubMed:26000965). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (By similarity). Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA- COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=; Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence=; Reaction=L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L- lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58220, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:15088, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:142515; Evidence=; Interacts with PARP1; leading to activate PARP1 in absence of DNA. Interacts with PRKDC. Interacts with XRCC5/Ku80; the interaction is dependent on nucleic acids. Interacts with XRCC6/Ku70; the interaction is dependent on nucleic acids. Interacts with EZH2, HDAC1, HDAC2, SUZ12, YY1, LRIG3 and LIG4. Nucleus Chromosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected. In response to DNA damage, localizes to sites of double-strand break. Also localizes to single-strand breaks. Preferentially localized to the daughter centriole. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3ULW8-1; Sequence=Displayed; Name=2; IsoId=Q3ULW8-2; Sequence=VSP_060032; Auto-ADP-ribosylated. No visible phenotype in normal conditions, but mutant mice are sensitive to ionizing radiation (PubMed:21270334). In B-cells, class switch recombination is increased, while somatic hypermutation is unaffected, due to increased occupancy of Aicda/Aid at the donor switch region (PubMed:26000965). Belongs to the ARTD/PARP family. telomere maintenance NAD+ ADP-ribosyltransferase activity nucleus nucleolus cytoplasm DNA repair double-strand break repair protein ADP-ribosylation cellular response to DNA damage stimulus transferase activity transferase activity, transferring glycosyl groups DNA ADP-ribosylation site of double-strand break negative regulation of isotype switching positive regulation of DNA ligation regulation of mitotic spindle organization protein poly-ADP-ribosylation protein auto-ADP-ribosylation negative regulation of telomerase RNA reverse transcriptase activity protein localization to site of double-strand break protein ADP-ribosylase activity positive regulation of double-strand break repair via nonhomologous end joining uc009rjy.1 uc009rjy.2 uc009rjy.3 
ENSMUST00000067219.5 Dach2 ENSMUST00000067219.5 dachshund family transcription factor 2, transcript variant 2 (from RefSeq NM_033605.2) DACH2_MOUSE ENSMUST00000067219.1 ENSMUST00000067219.2 ENSMUST00000067219.3 ENSMUST00000067219.4 NM_033605 Q8BMA0 Q925Q8 uc009uds.1 uc009uds.2 uc009uds.3 Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression. Probably binds to DNA via its DACHbox-N domain. Interacts with SIX6. Interacts with EYA2 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q925Q8-1; Sequence=Displayed; Name=2; IsoId=Q925Q8-2; Sequence=VSP_009493, VSP_009494; Name=3; IsoId=Q925Q8-3; Sequence=VSP_009495, VSP_009496, VSP_009497; Expressed in embryo, and at lower levels in the newborn. From 8.5 to 14.5 dpc detected in nervous tissue. In the brain detected at 8.5 dpc within the prospective hindbrain, but not within the developing forebrain or midbrain. At 9.5 dpc expressed within the ventral prosencephalon, hindbrain and forebrain. Expression within the forebrain neuroectoderm flanked the optic vesicle with rostral and caudal restrictions. In addition, dorsal and ventral expression domains were observed within the hindbrain. At 10.5 to 12.5 dpc detected in the dorsal mesencephalon, in addition to the telencephalon and hindbrain. At 14.5 dpc visible in the olfactory bulbs. Detected from 9.5 to 12.5 dpc in the dorsal neural tube with the highest expression near the hindbrain. At 9.5 and 10.5 dpc detected in cells located in the dorsal and ventral neural tube and dorsal root ganglia. Detected during the development of the optic and the auditory systems. At 10.5 dpc, a small ring of ocular staining was observed suggesting expression in the lens pit. At 10.5 dpc expressed in the developing lens epithelium and in the mesenchyme surrounding the retina. However, expression in the lens placode ectoderm was not detected, suggesting that DACH2 is activated after lens vesicle formation. Low levels of expression could also be detected in the peripheral neuroretina at 10.5 and 12.5 dpc. Detected in the otic pit at 9.5 dpc and in the otic endolymphatic duct at 10.5, 11.5 and 12.5 dpc. From 10.5 to 14.5 dpc detected in the developing fore and hind limbs. At 10.5 and 11.5 dpc observed in the anterior and posterior margins and presumptive hand plate of the limb bud. At 9.5 and 10.5 dpc expressed in the limb. At 12.5 dpc is detected in the hand plate with strong expression at the margins of the limb plate. At 14.5 dpc detected in the hand plate and lateral edges of the digits. At 8.5 dpc expression was not detected in the developing somites. In contrast, from 9.5 to 12.5 dpc, expression is detected in a repeated pattern located lateral to the neural tube and in the interlimb bud region suggesting expression in somite derivatives. At 9.5 dpc detected in the forelimb dermamyotome. Also located along the lateral portion of the trunk and within a dorsal domain within the limb bud. At 10.5 dpc expressed in lateral and limb mesoderm. From 9.5 to 10.5 dpc detected in head mesenchyme and the branchial arches. At 9.5 and 10 dpc. expressed in the head mesoderm associated with the developing eye. At 10.5 dpc this pattern appears as a ring of expression surrounding the eye. At 11.5 dpc expression is still detectable in the branchial arches with strong expression at the cranial sinus. At 14.5 dpc mammary gland primordia. Detected in the nasal openings and vibrissae. The DACHbox-N domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain. Belongs to the DACH/dachshund family. DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated multicellular organism development development of primary female sexual characteristics uc009uds.1 uc009uds.2 uc009uds.3 
ENSMUST00000067230.6 Sox4 ENSMUST00000067230.6 SRY (sex determining region Y)-box 4 (from RefSeq NM_009238.3) ENSMUST00000067230.1 ENSMUST00000067230.2 ENSMUST00000067230.3 ENSMUST00000067230.4 ENSMUST00000067230.5 NM_009238 Q06831 Q5SW95 SOX4_MOUSE Sox-4 Sox4 uc007pyk.1 uc007pyk.2 uc007pyk.3 uc007pyk.4 Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:8404853). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (PubMed:23562159). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311). Interacts with UBE2I. Interacts with HDAC1; interaction inhibits the transcriptional activator activity. Q06831; P15884: TCF4; Xeno; NbExp=2; IntAct=EBI-6262177, EBI-533224; Nucleus Expressed in both gamma-delta T-cells and Cd4+ Cd8+ double-positive (DP) alpha-beta T-cells (PubMed:17218525). Expressed in the ovaries and the thymus (PubMed:8404853, PubMed:17218525). Expressed in molar and incisor tooth germs at 14.5 dpc. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Acetylation at Lys-95 by KAT5 promotes the transcription activator activity and is required during myoblast differentiation (By similarity). Acetylation by KAT5 abolishes the interaction between SOX4 and HDAC1 and switches SOX4 into a transcriptional activator (By similarity). In T-cell-specific knockout mice, loss of mature Il17a-producing Vgamma2-positive gamma-delta T-cells and reduction of Rorc expression in immature Vgamma2-positive thymocytes (PubMed:23562159). In a mouse model for psoriasis, dermal inflammation induced by skin application of TLR7 synthetic ligand imiquimod is substantially reduced due to the absence of Vgamma2-positive gamma- delta T-cells (PubMed:23562159). May be involved in the T-cell immune response in the psoriasis-like disease which is induced in mice by the application of the TLR7 ligand Imiquimod to skin. transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development response to hypoxia neural tube formation pro-B cell differentiation mitral valve morphogenesis cardiac ventricle formation cardiac right ventricle morphogenesis atrial septum primum morphogenesis noradrenergic neuron differentiation DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus nucleoplasm cytoplasm mitochondrion regulation of transcription, DNA-templated DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest heart development positive regulation of cell proliferation negative regulation of cell proliferation glial cell proliferation spinal cord development spinal cord motor neuron differentiation glial cell development cell differentiation T cell differentiation endocrine pancreas development negative regulation of protein ubiquitination regulation of protein stability positive regulation of insulin secretion somatic stem cell population maintenance ascending aorta morphogenesis glucose homeostasis DNA damage response, detection of DNA damage positive regulation of apoptotic process nuclear transcription factor complex positive regulation of translation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter sympathetic nervous system development protein stabilization limb bud formation ventricular septum morphogenesis negative regulation of cell death neuroepithelial cell differentiation kidney morphogenesis cellular response to glucose stimulus positive regulation of canonical Wnt signaling pathway positive regulation of N-terminal peptidyl-lysine acetylation uc007pyk.1 uc007pyk.2 uc007pyk.3 uc007pyk.4 
ENSMUST00000067232.10 Ctnnd1 ENSMUST00000067232.10 catenin delta 1, transcript variant 1 (from RefSeq NM_007615.4) CTND1_MOUSE Catns ENSMUST00000067232.1 ENSMUST00000067232.2 ENSMUST00000067232.3 ENSMUST00000067232.4 ENSMUST00000067232.5 ENSMUST00000067232.6 ENSMUST00000067232.7 ENSMUST00000067232.8 ENSMUST00000067232.9 Kiaa0384 NM_007615 P30999 Q3TSU9 Q80XQ4 Q8CHF8 uc008kiq.1 uc008kiq.2 uc008kiq.3 Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin/CDH1, alpha-catenin/CTNNA1, beta-catenin/CTNNB1, and gamma-catenin/JUP. Binds to the C-terminal fragment of PSEN1 and mutually competes for CDH1 (By similarity). Interacts with ZBTB33 (PubMed:10207085, PubMed:12087177). Interacts with GLIS2 (PubMed:17344476). Interacts with FER (By similarity). Interacts with NANOS1 (via N-terminal region) (By similarity). Interacts (via N- terminus) with GNA12; the interaction regulates CDH1-mediated cell-cell adhesion (PubMed:15240885). Interacts with GNA13 (PubMed:15240885). Component of a cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1 (By similarity). Interacts with CCDC85B (By similarity). Interacts with PLPP3; negatively regulates the PLPP3-mediated stabilization of CTNNB1 (By similarity). P30999; Q60598: Cttn; NbExp=4; IntAct=EBI-529924, EBI-397955; P30999; P35235: Ptpn11; NbExp=3; IntAct=EBI-529924, EBI-397236; P30999; Q8BN78: Zbtb33; NbExp=3; IntAct=EBI-529924, EBI-1216314; Cell junction, adherens junction Cytoplasm cleus ll membrane Note=Interaction with GLIS2 promotes nuclear translocation (PubMed:17344476). Detected at cell-cell contacts (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (By similarity). CDH1 enhances cell membrane localization (By similarity). [Isoform 2]: Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P30999-1; Sequence=Displayed; Name=2; IsoId=P30999-2; Sequence=VSP_030567, VSP_030568; Name=3; IsoId=P30999-3; Sequence=VSP_030568; Expressed in basal keratinocytes (at protein level). Expressed at the outer limiting membrane of the retina at 18.5 dpc. ARM repeats 1 to 5 mediate interaction with cadherins. Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ (By similarity). Belongs to the beta-catenin family. Sequence=BAC41421.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; morphogenesis of a polarized epithelium kidney development receptor binding protein binding nucleus cytoplasm cytosol plasma membrane cell-cell junction cell-cell adherens junction zonula adherens bicellular tight junction cell-cell junction assembly cell adhesion salivary gland morphogenesis positive regulation of protein processing membrane Wnt signaling pathway catenin complex flotillin complex protein kinase binding protein phosphatase binding protein domain specific binding lamellipodium growth cone midbody dendritic spine synapse cadherin binding cell adhesion molecule binding epithelial cell differentiation involved in salivary gland development glomerulus morphogenesis negative regulation of canonical Wnt signaling pathway cell-cell adhesion presynaptic active zone cytoplasmic component glutamatergic synapse regulation of postsynaptic specialization membrane neurotransmitter receptor levels postsynaptic density, intracellular component positive regulation of peptidyl-tyrosine autophosphorylation uc008kiq.1 uc008kiq.2 uc008kiq.3 
ENSMUST00000067246.6 Slc30a5 ENSMUST00000067246.6 solute carrier family 30 (zinc transporter), member 5 (from RefSeq NM_022885.2) ENSMUST00000067246.1 ENSMUST00000067246.2 ENSMUST00000067246.3 ENSMUST00000067246.4 ENSMUST00000067246.5 NM_022885 Q8BQA0 Q8K315 Q8R4H9 Slc30a5 ZNT5_MOUSE Znt5 uc007rrr.1 uc007rrr.2 Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis. Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin. Reaction=2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out); Xref=Rhea:RHEA:72627, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105; Evidence=; Heterodimer with SLC30A6/ZNT6; form a functional zinc ion transmembrane transporter. Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein Cytoplasmic vesicle, COPII-coated vesicle membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Note=Enriched in early compartments of the secretory pathway including COPII-coated vesicles and the Golgi cis cisterna. Ubiquitously expressed. Could homodimerize through the formation of dityrosine bonds upon oxidative stress. Homozygous knockout mice are viable and fertile (PubMed:12095919). However, they grow poorly and display lean phenotype, muscle weakness, osteopenia due to impairment of osteoblast maturation to osteocyte and male-specific sudden cardiac death associated with bradyarrhythmia (PubMed:12095919). Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. Sequence=BAC34549.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; zinc ion transmembrane transporter activity nucleus nucleolus Golgi apparatus ion transport cation transport cobalt ion transport zinc II ion transport cellular zinc ion homeostasis cation transmembrane transporter activity response to zinc ion membrane integral component of membrane apical plasma membrane secretory granule transmembrane transport zinc II ion transmembrane transport cation transmembrane transport uc007rrr.1 uc007rrr.2 
ENSMUST00000067252.14 Piezo1 ENSMUST00000067252.14 piezo-type mechanosensitive ion channel component 1, transcript variant 2 (from RefSeq NM_001037298.1) E9PUQ9 E9PUQ9_MOUSE ENSMUST00000067252.1 ENSMUST00000067252.10 ENSMUST00000067252.11 ENSMUST00000067252.12 ENSMUST00000067252.13 ENSMUST00000067252.2 ENSMUST00000067252.3 ENSMUST00000067252.4 ENSMUST00000067252.5 ENSMUST00000067252.6 ENSMUST00000067252.7 ENSMUST00000067252.8 ENSMUST00000067252.9 Fam38a NM_001037298 Piezo1 uc012gme.1 uc012gme.2 Membrane ulti-pass membrane protein Belongs to the PIEZO (TC 1.A.75) family. Lacks conserved residue(s) required for the propagation of feature annotation. endoplasmic reticulum mechanically-gated ion channel activity membrane integral component of membrane positive regulation of integrin activation positive regulation of cell-cell adhesion mediated by integrin transmembrane transport uc012gme.1 uc012gme.2 
ENSMUST00000067258.9 Adra1b ENSMUST00000067258.9 adrenergic receptor, alpha 1b, transcript variant 3 (from RefSeq NM_001284381.1) Adra1b ENSMUST00000067258.1 ENSMUST00000067258.2 ENSMUST00000067258.3 ENSMUST00000067258.4 ENSMUST00000067258.5 ENSMUST00000067258.6 ENSMUST00000067258.7 ENSMUST00000067258.8 NM_001284381 Q9DBL0 Q9DBL0_MOUSE uc007imz.1 uc007imz.2 uc007imz.3 uc007imz.4 This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. Cell membrane ; Multi-pass membrane protein Cytoplasm Membrane ; Multi-pass membrane protein Nucleus membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity adrenergic receptor activity alpha1-adrenergic receptor activity nucleus cytoplasm plasma membrane regulation of muscle contraction signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane regulation of vasoconstriction nuclear membrane positive regulation of MAPK cascade protein heterodimerization activity regulation of cardiac muscle contraction adrenergic receptor signaling pathway uc007imz.1 uc007imz.2 uc007imz.3 uc007imz.4 
ENSMUST00000067268.15 Pxn ENSMUST00000067268.15 paxillin, transcript variant alpha (from RefSeq NM_011223.4) ENSMUST00000067268.1 ENSMUST00000067268.10 ENSMUST00000067268.11 ENSMUST00000067268.12 ENSMUST00000067268.13 ENSMUST00000067268.14 ENSMUST00000067268.2 ENSMUST00000067268.3 ENSMUST00000067268.4 ENSMUST00000067268.5 ENSMUST00000067268.6 ENSMUST00000067268.7 ENSMUST00000067268.8 ENSMUST00000067268.9 NM_011223 PAXI_MOUSE Q3TB62 Q3TZQ6 Q8VI36 Q8VI37 uc008zeb.1 uc008zeb.2 uc008zeb.3 Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. Interacts in vitro with VCL/vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of CRK (By similarity). Interacts with GIT1 (By similarity). Interacts with NUDT16L1/SDOS (PubMed:11805099). Interacts with PTK2/FAK1 (PubMed:11799401). Interacts with PTK2B/PYK2 (PubMed:8940124). Interacts with ASAP2 (By similarity). Interacts with unphosphorylated ITGA4 (By similarity). Interacts with RNF5 (By similarity). Interacts with PDCD10 (By similarity). Interacts with NEK3, the interaction is prolactin-dependent (By similarity). Interacts with PTK6 (By similarity). Interacts with TGFB1I1 (By similarity). Interacts with SORBS1 (By similarity). Interacts with PARVB (By similarity). Interacts (via LD motif 4) with PARVA/PARVIN (PubMed:11134073). Interacts (via LD motif 4) with ILK (By similarity). Interacts (via cytoplasmic domain) with CEACAM1; the interaction is phosphotyrosyl-dependent (By similarity). Interacts with LIMA1; this complex stabilizes actin dynamics (By similarity). Interacts with CD36 (via C-terminus) (By similarity). Interacts with TRIM15 (By similarity). Q8VI36; P11627: L1cam; NbExp=2; IntAct=EBI-983394, EBI-397964; Q8VI36; P34152: Ptk2; NbExp=5; IntAct=EBI-983394, EBI-77070; Q8VI36; Q64727: Vcl; NbExp=3; IntAct=EBI-983394, EBI-432047; Q8VI36; P18031: PTPN1; Xeno; NbExp=2; IntAct=EBI-983394, EBI-968788; Cytoplasm, cytoskeleton Cell junction, focal adhesion Cytoplasm, cell cortex Note=Colocalizes with integrins at the cell periphery. Colocalizes with PXN to membrane ruffles and the leading edge of migrating cells (By similarity). Event=Alternative splicing; Named isoforms=2; Name=Beta; IsoId=Q8VI36-1; Sequence=Displayed; Name=Alpha; IsoId=Q8VI36-2; Sequence=VSP_016357; Phosphorylated by MAPK1/ERK2. Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation (By similarity). Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion (By similarity). Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (By similarity). Belongs to the paxillin family. activation of MAPK activity stress fiber transcription cofactor activity integrin binding protein binding cytoplasm cytosol cytoskeleton plasma membrane adherens junction focal adhesion cell cortex cytoskeleton organization cell adhesion transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway beta-catenin binding regulation of cell shape vinculin binding peptidyl-tyrosine phosphorylation protein kinase binding protein phosphatase binding lamellipodium lamellipodium assembly cell junction receptor signaling complex scaffold activity cell leading edge ubiquitin protein ligase binding substrate adhesion-dependent cell spreading neuropilin binding endothelial cell migration macromolecular complex binding positive regulation of angiogenesis positive regulation of protein kinase activity metal ion binding focal adhesion assembly branching morphogenesis of an epithelial tube BH4 domain binding positive regulation of stress fiber assembly growth hormone receptor signaling pathway response to peptide regulation of nucleic acid-templated transcription uc008zeb.1 uc008zeb.2 uc008zeb.3 
ENSMUST00000067284.10 Cpsf3 ENSMUST00000067284.10 cleavage and polyadenylation specificity factor 3, transcript variant 4 (from RefSeq NR_186677.1) CPSF3_MOUSE Cpsf73 ENSMUST00000067284.1 ENSMUST00000067284.2 ENSMUST00000067284.3 ENSMUST00000067284.4 ENSMUST00000067284.5 ENSMUST00000067284.6 ENSMUST00000067284.7 ENSMUST00000067284.8 ENSMUST00000067284.9 NR_186677 Q8CIM0 Q9QXK7 uc007ndp.1 uc007ndp.2 uc007ndp.3 uc007ndp.4 Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as an mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3' endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'- ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre- mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (PubMed:26255770, PubMed:29804889). Required for entering/progressing through S-phase of the cell cycle (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (PubMed:26255770). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (PubMed:29804889). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with CPSF2, CSTF2 and SYMPK. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3'UTR of pre-mRNAs. Interacts with WDR33 (By similarity). Interacts with ZC3H3 (PubMed:16115198). Interacts with ISY1; this interaction is in an RNA independent manner (PubMed:26255770). Interacts with the microprocessor complex subunits DGCR8 and DROSHA; this interaction is in an RNA dependent manner (PubMed:26255770). Nucleus Sumoylated on Lys-462, Lys-465 and Lys-545, preferentially by SUMO3. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. CPSF3 subfamily. RNA binding nuclease activity endonuclease activity endoribonuclease activity nucleus mRNA cleavage and polyadenylation specificity factor complex mRNA polyadenylation mRNA processing mRNA 3'-end processing by stem-loop binding and cleavage 5'-3' exonuclease activity hydrolase activity metal ion binding nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc007ndp.1 uc007ndp.2 uc007ndp.3 uc007ndp.4 
ENSMUST00000067298.5 Mrps21 ENSMUST00000067298.5 mitochondrial ribosomal protein S21, transcript variant 1 (from RefSeq NM_078479.4) ENSMUST00000067298.1 ENSMUST00000067298.2 ENSMUST00000067298.3 ENSMUST00000067298.4 Mrps21 NM_078479 Q059G7 Q059G7_MOUSE uc008qlj.1 uc008qlj.2 uc008qlj.3 Belongs to the bacterial ribosomal protein bS21 family. structural constituent of ribosome mitochondrial small ribosomal subunit ribosome translation uc008qlj.1 uc008qlj.2 uc008qlj.3 
ENSMUST00000067318.6 Lce3a ENSMUST00000067318.6 late cornified envelope 3A (from RefSeq NM_001039594.2) ENSMUST00000067318.1 ENSMUST00000067318.2 ENSMUST00000067318.3 ENSMUST00000067318.4 ENSMUST00000067318.5 Lce3a NM_001039594 Q497I5 Q497I5_MOUSE uc008qev.1 uc008qev.2 Belongs to the LCE family. epidermis development uc008qev.1 uc008qev.2 
ENSMUST00000067327.11 Cdkn1b ENSMUST00000067327.11 Important regulator of cell cycle progression (PubMed:8033213, PubMed:12972555). Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (By similarity). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes (PubMed:8033213). Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (from UniProt P46414) AK050240 CDN1B_MOUSE ENSMUST00000067327.1 ENSMUST00000067327.10 ENSMUST00000067327.2 ENSMUST00000067327.3 ENSMUST00000067327.4 ENSMUST00000067327.5 ENSMUST00000067327.6 ENSMUST00000067327.7 ENSMUST00000067327.8 ENSMUST00000067327.9 P46414 Q8BG74 uc009ela.1 uc009ela.2 uc009ela.3 uc009ela.4 Important regulator of cell cycle progression (PubMed:8033213, PubMed:12972555). Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (By similarity). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes (PubMed:8033213). Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. Forms a ternary complex composed of CCNE1, CDK2 and CDKN1B. Interacts directly with CCNE1; the interaction is inhibited by CDK2- dependent phosphorylation on Thr-187. Interacts with COPS5, subunit of the COP9 signalosome complex; the interaction leads to CDKN1B degradation. Interacts with NUP50; the interaction leads to nuclear import and degradation of phosphorylated CDKN1B. Interacts with CCND1 and SNX6 (By similarity). Interacts (Thr-197-phosphorylated form) with 14-3-3 proteins, binds strongly YWHAQ, weakly YWHAE and YWHAH, but not YWHAB nor YWHAZ; the interaction with YWHAQ results in translocation to the cytoplasm. Interacts with AKT1 and LYN; the interactions lead to cytoplasmic mislocation, phosphorylation of CDKN1B and inhibition of cell cycle arrest. Forms a ternary complex with CCNA2 and CDK2; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements. Interacts (unphosphorylated form) with CDK2. Forms a complex with CDK2 and SPDYA, but does not directly interact with SPDYA. Forms a ternary complex composed of cyclin D, CDK4 and CDKN1B. Interacts (phosphorylated on Tyr-88 and Tyr-89) with CDK4; the interaction is required for cyclin D and CDK4 complex assembly, induces nuclear translocation and activates the CDK4 kinase activity. Interacts with GRB2. Interacts with PIM1. Identified in a complex with SKP1, SKP2 and CKS1B. Interacts with UHMK1; the interaction leads to cytoplasmic mislocation, phosphorylation of CDKN1B and inhibition of cell cycle arrest. Interacts also with CDK1. Dephosphorylated on Thr-187 by PPM1H, leading to CDKN1B stability (By similarity). P46414; P30285: Cdk4; NbExp=2; IntAct=EBI-1005742, EBI-847225; P46414; Q61881: Mcm7; NbExp=2; IntAct=EBI-1005742, EBI-457180; P46414; P54227: Stmn1; NbExp=2; IntAct=EBI-1005742, EBI-1006438; Nucleus. Cytoplasm. Endosome Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-197, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89 (By similarity). Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (PubMed:20228253). A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activity. Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is the major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability. Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, MYC and in certain cancer cell lines. The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-197 is required for interaction with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK1 and CDK2 leads to protein ubiquitination and proteasomal degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF (By similarity). Dephosphorylated on Thr-187 by PPM1H, leading to CDKN1B stability (By similarity). Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus, by SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing SCF(SKP2)-like complex; leads to its degradation (By similarity). Subject to degradation in the lysosome. Interaction with SNX6 promotes lysosomal degradation. Belongs to the CDI family. G1/S transition of mitotic cell cycle response to hypoxia placenta development protein kinase inhibitor activity cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding nucleus cytoplasm endosome cytosol potassium ion transport cell cycle cell cycle arrest regulation of exit from mitosis Notch signaling pathway heart development sensory perception of sound cell death positive regulation of cell proliferation negative regulation of cell proliferation response to glucose positive regulation of cell death response to organic cyclic compound protein kinase binding protein phosphatase binding negative regulation of cell growth cyclin binding Hsp70 protein binding positive regulation of microtubule polymerization Cul4A-RING E3 ubiquitin ligase complex response to estradiol macromolecular complex negative regulation of kinase activity regulation of cell proliferation negative regulation of phosphorylation response to drug negative regulation of apoptotic process response to amino acid intracellular membrane-bounded organelle response to peptide hormone macromolecular complex binding positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell cycle negative regulation of transcription, DNA-templated negative regulation of mitotic cell cycle response to cadmium ion autophagic cell death inner ear development negative regulation of epithelial cell proliferation chaperone binding negative regulation of cellular component movement negative regulation of epithelial cell proliferation involved in prostate gland development cellular response to antibiotic cellular response to lithium ion cellular response to organic cyclic compound mitotic cell cycle arrest regulation of lens fiber cell differentiation negative regulation of cyclin-dependent protein kinase activity negative regulation of vascular smooth muscle cell proliferation negative regulation of cardiac muscle tissue regeneration uc009ela.1 uc009ela.2 uc009ela.3 uc009ela.4 
ENSMUST00000067328.7 Cyp2c67 ENSMUST00000067328.7 cytochrome P450, family 2, subfamily c, polypeptide 67, transcript variant 2 (from RefSeq NM_001417644.1) Cyp2c40 Cyp2c67 Cyp2c68 E9QAE5 ENSMUST00000067328.1 ENSMUST00000067328.2 ENSMUST00000067328.3 ENSMUST00000067328.4 ENSMUST00000067328.5 ENSMUST00000067328.6 NM_001417644 Q569X9 Q569X9_MOUSE uc008hkc.1 uc008hkc.2 uc008hkc.3 uc008hkc.4 Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc008hkc.1 uc008hkc.2 uc008hkc.3 uc008hkc.4 
ENSMUST00000067354.10 Depp1 ENSMUST00000067354.10 Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS. (from UniProt Q8K2F3) AK078806 DEPP1_MOUSE Depp ENSMUST00000067354.1 ENSMUST00000067354.2 ENSMUST00000067354.3 ENSMUST00000067354.4 ENSMUST00000067354.5 ENSMUST00000067354.6 ENSMUST00000067354.7 ENSMUST00000067354.8 ENSMUST00000067354.9 Fseg Q8BU66 Q8K2F3 uc009dkp.1 uc009dkp.2 uc009dkp.3 uc009dkp.4 Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS. Cytoplasm Peroxisome Mitochondrion Note=May localize to aggresomes. Up-regulated by hypoxia. molecular_function cytoplasm mitochondrion peroxisome autophagy regulation of autophagy uc009dkp.1 uc009dkp.2 uc009dkp.3 uc009dkp.4 
ENSMUST00000067375.5 Bsx ENSMUST00000067375.5 brain specific homeobox (from RefSeq NM_178245.3) BSH_MOUSE Bsx ENSMUST00000067375.1 ENSMUST00000067375.2 ENSMUST00000067375.3 ENSMUST00000067375.4 NM_178245 Q3SXB1 Q810B3 uc009paa.1 uc009paa.2 uc009paa.3 DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance. [Isoform 1]: Nucleus [Isoform 2]: Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Bsxla; IsoId=Q810B3-1; Sequence=Displayed; Name=2; Synonyms=Bsxlb; IsoId=Q810B3-2; Sequence=VSP_027570, VSP_027571; Expressed in brain. In brain, it is restricted to a few specific developing brain structures such as pineal gland, telencephalic septum, hypothalamic pre-mammillary body and arcuate nucleus. Expressed in early embryonic stages of epiphysis development from 9.5 dpc onwards. Belongs to the distal-less homeobox family. Name=Protein Spotlight; Note=Of fidgets and food - Issue 85 of August 2007; URL="https://web.expasy.org/spotlight/back_issues/085"; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter brain development locomotory behavior eating behavior sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter mammary gland involution uc009paa.1 uc009paa.2 uc009paa.3 
ENSMUST00000067384.6 Rhob ENSMUST00000067384.6 ras homolog family member B (from RefSeq NM_007483.3) ENSMUST00000067384.1 ENSMUST00000067384.2 ENSMUST00000067384.3 ENSMUST00000067384.4 ENSMUST00000067384.5 NM_007483 Q4FJM5 Q4FJM5_MOUSE Rhob uc007mzp.1 uc007mzp.2 uc007mzp.3 uc007mzp.4 Belongs to the small GTPase superfamily. Rho family. nucleotide binding mitotic cytokinesis GTPase activity GTP binding cytosol plasma membrane small GTPase mediated signal transduction endosome to lysosome transport endosome membrane positive regulation of endothelial cell migration membrane regulation of cell migration negative regulation of cell migration cleavage furrow positive regulation of apoptotic process endothelial tube morphogenesis cellular response to hydrogen peroxide cellular response to ionizing radiation uc007mzp.1 uc007mzp.2 uc007mzp.3 uc007mzp.4 
ENSMUST00000067386.14 2310022A10Rik ENSMUST00000067386.14 RIKEN cDNA 2310022A10 gene, transcript variant 1 (from RefSeq NM_175107.5) 2310022A10Rik ENSMUST00000067386.1 ENSMUST00000067386.10 ENSMUST00000067386.11 ENSMUST00000067386.12 ENSMUST00000067386.13 ENSMUST00000067386.2 ENSMUST00000067386.3 ENSMUST00000067386.4 ENSMUST00000067386.5 ENSMUST00000067386.6 ENSMUST00000067386.7 ENSMUST00000067386.8 ENSMUST00000067386.9 G5E8E3 G5E8E3_MOUSE NM_175107 uc009fwo.1 uc009fwo.2 uc009fwo.3 uc009fwo.4 uc009fwo.5 uc009fwo.6 nucleoplasm uc009fwo.1 uc009fwo.2 uc009fwo.3 uc009fwo.4 uc009fwo.5 uc009fwo.6 
ENSMUST00000067399.14 B3gntl1 ENSMUST00000067399.14 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 (from RefSeq NM_178664.5) B3GNL_MOUSE B7ZNC6 ENSMUST00000067399.1 ENSMUST00000067399.10 ENSMUST00000067399.11 ENSMUST00000067399.12 ENSMUST00000067399.13 ENSMUST00000067399.2 ENSMUST00000067399.3 ENSMUST00000067399.4 ENSMUST00000067399.5 ENSMUST00000067399.6 ENSMUST00000067399.7 ENSMUST00000067399.8 ENSMUST00000067399.9 NM_178664 Q3U129 Q5HZJ4 Q8BLR1 Q8C0H0 Q8R1Y3 uc007mwb.1 uc007mwb.2 uc007mwb.3 uc007mwb.4 Putative glycosyltransferase. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U129-1; Sequence=Displayed; Name=2; IsoId=Q3U129-2; Sequence=VSP_025965; Name=3; IsoId=Q3U129-3; Sequence=VSP_025966, VSP_025967; Belongs to the glycosyltransferase 2 family. cellular_component biological_process transferase activity transferase activity, transferring glycosyl groups uc007mwb.1 uc007mwb.2 uc007mwb.3 uc007mwb.4 
ENSMUST00000067404.13 Fgfr1op2 ENSMUST00000067404.13 FGFR1 oncogene partner 2, transcript variant 2 (from RefSeq NM_001347513.1) ENSMUST00000067404.1 ENSMUST00000067404.10 ENSMUST00000067404.11 ENSMUST00000067404.12 ENSMUST00000067404.2 ENSMUST00000067404.3 ENSMUST00000067404.4 ENSMUST00000067404.5 ENSMUST00000067404.6 ENSMUST00000067404.7 ENSMUST00000067404.8 ENSMUST00000067404.9 FGOP2_MOUSE NM_001347513 Q3TEX1 Q3TW81 Q9CRA9 Q9D7R0 uc009esd.1 uc009esd.2 uc009esd.3 May be involved in wound healing pathway. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CRA9-1; Sequence=Displayed; Name=2; IsoId=Q9CRA9-2; Sequence=VSP_027541; Belongs to the SIKE family. cytoplasm response to wounding wound healing protein homodimerization activity uc009esd.1 uc009esd.2 uc009esd.3 
ENSMUST00000067414.13 Nav1 ENSMUST00000067414.13 neuron navigator 1, transcript variant 2 (from RefSeq NM_173437.2) ENSMUST00000067414.1 ENSMUST00000067414.10 ENSMUST00000067414.11 ENSMUST00000067414.12 ENSMUST00000067414.2 ENSMUST00000067414.3 ENSMUST00000067414.4 ENSMUST00000067414.5 ENSMUST00000067414.6 ENSMUST00000067414.7 ENSMUST00000067414.8 ENSMUST00000067414.9 Kiaa1151 NAV1_MOUSE NM_173437 Pomfil3 Q3U5B6 Q68EE8 Q6PB78 Q80TI7 Q8BKG2 Q8BUT5 Q8CH77 uc033fll.1 uc033fll.2 uc033fll.3 May be involved in neuronal migration. Interacts with tubulin. Cytoplasm, cytoskeleton Note=Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8CH77-1; Sequence=Displayed; Name=2; IsoId=Q8CH77-2; Sequence=VSP_025262, VSP_025263; Name=3; IsoId=Q8CH77-3; Sequence=VSP_025263, VSP_025266, VSP_025267; Name=4; IsoId=Q8CH77-4; Sequence=VSP_025260, VSP_025261, VSP_025264, VSP_025265; Expressed in heart and brain. Present in brain (at protein level). In adult brain, found almost exclusively in areas of secondary neurogenesis from the hippocampus and the subventricular zone. Expressed in neural structures at 10 dpc. At 13 dpc and 15 dpc, highly expressed in neural tube, somites, heart and dispersed cells in tongue and face. At P5, widely expressed through the central nervous system in post-mitotic post-migratory zones. Brain expression decreases rapidly from P5 to P21 (at protein level). Belongs to the Nav/unc-53 family. Sequence=BAC65740.1; Type=Erroneous initiation; Evidence=; microtubule bundle formation neuron migration cytoplasm cytoskeleton microtubule multicellular organism development nervous system development microtubule cytoskeleton neurogenesis cell differentiation axon initial segment uc033fll.1 uc033fll.2 uc033fll.3 
ENSMUST00000067425.6 Zfp747 ENSMUST00000067425.6 zinc finger protein 747 (from RefSeq NM_175560.3) ENSMUST00000067425.1 ENSMUST00000067425.2 ENSMUST00000067425.3 ENSMUST00000067425.4 ENSMUST00000067425.5 NM_175560 Q6PDC4 Q8BHM7 Q8BHM7_MOUSE Zfp747 uc009jvd.1 uc009jvd.2 Nucleus nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009jvd.1 uc009jvd.2 
ENSMUST00000067426.6 Cdkn3 ENSMUST00000067426.6 cyclin dependent kinase inhibitor 3, transcript variant 2 (from RefSeq NM_028222.2) CDKN3_MOUSE Cdkn3 ENSMUST00000067426.1 ENSMUST00000067426.2 ENSMUST00000067426.3 ENSMUST00000067426.4 ENSMUST00000067426.5 Kap NM_028222 Q810P3 Q9CWS3 uc007thf.1 uc007thf.2 uc007thf.3 uc007thf.4 May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity (By similarity). Cytoplasm, perinuclear region Belongs to the protein-tyrosine phosphatase family. Sequence=BAB26929.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=BAC28238.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein binding cytoplasm cytosol protein dephosphorylation cellular response to DNA damage stimulus cell cycle cell cycle arrest dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation perinuclear region of cytoplasm cilium assembly uc007thf.1 uc007thf.2 uc007thf.3 uc007thf.4 
ENSMUST00000067443.10 Slfn5 ENSMUST00000067443.10 schlafen 5 (from RefSeq NM_183201.4) ENSMUST00000067443.1 ENSMUST00000067443.2 ENSMUST00000067443.3 ENSMUST00000067443.4 ENSMUST00000067443.5 ENSMUST00000067443.6 ENSMUST00000067443.7 ENSMUST00000067443.8 ENSMUST00000067443.9 NM_183201 Q148Z1 Q3V3H0 Q5QNT5 Q7TMA8 Q8CBA2 SLFN5_MOUSE uc007knz.1 uc007knz.2 uc007knz.3 uc007knz.4 May have a role in hematopoietic cell differentiation. Belongs to the Schlafen family. Subgroup III subfamily. nucleotide binding ATP binding nucleus cell differentiation uc007knz.1 uc007knz.2 uc007knz.3 uc007knz.4 
ENSMUST00000067444.10 Gfap ENSMUST00000067444.10 glial fibrillary acidic protein, transcript variant 2 (from RefSeq NM_010277.3) A1E2H7 A2AH87 B2RTI7 ENSMUST00000067444.1 ENSMUST00000067444.2 ENSMUST00000067444.3 ENSMUST00000067444.4 ENSMUST00000067444.5 ENSMUST00000067444.6 ENSMUST00000067444.7 ENSMUST00000067444.8 ENSMUST00000067444.9 GFAP_MOUSE NM_010277 P03995 Q09J71 Q3USS4 Q496R4 Q496S3 Q7TQ30 Q80VX6 Q925K2 Q925K3 uc007lsw.1 uc007lsw.2 uc007lsw.3 uc007lsw.4 GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Interacts with SYNM. [Isoform 2]: Interacts with PSEN1 (via N-terminus). Cytoplasm Note=Associated with intermediate filaments. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=GFAP alpha ; IsoId=P03995-1; Sequence=Displayed; Name=2; Synonyms=GFAP epsilon ; IsoId=P03995-2; Sequence=VSP_017053; Brain; isoform 2 expressed at 20-fold lower level than isoform 1. Phosphorylated by PKN1. Belongs to the intermediate filament family. Sequence=CAA26571.1; Type=Erroneous initiation; Evidence=; integrin binding structural constituent of cytoskeleton protein binding cytoplasm cytoskeleton intermediate filament response to wounding positive regulation of Schwann cell proliferation negative regulation of neuron projection development astrocyte development membrane kinase binding extracellular matrix organization neuron projection regeneration identical protein binding cell projection myelin sheath cell body intermediate filament-based process intermediate filament organization regulation of neurotransmitter uptake Bergmann glial cell differentiation positive regulation of glial cell proliferation long-term synaptic potentiation glial cell projection astrocyte projection astrocyte end-foot cytoplasmic side of lysosomal membrane regulation of chaperone-mediated autophagy uc007lsw.1 uc007lsw.2 uc007lsw.3 uc007lsw.4 
ENSMUST00000067450.4 2700046A07Rik ENSMUST00000067450.4 RIKEN cDNA 2700046A07 gene (from RefSeq NR_037693.1) ENSMUST00000067450.1 ENSMUST00000067450.2 ENSMUST00000067450.3 NR_037693 uc008fdk.1 uc008fdk.2 uc008fdk.3 uc008fdk.4 uc008fdk.1 uc008fdk.2 uc008fdk.3 uc008fdk.4 
ENSMUST00000067458.7 Sema5a ENSMUST00000067458.7 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A (from RefSeq NM_009154.2) ENSMUST00000067458.1 ENSMUST00000067458.2 ENSMUST00000067458.3 ENSMUST00000067458.4 ENSMUST00000067458.5 ENSMUST00000067458.6 NM_009154 Q3UPZ0 Q3UPZ0_MOUSE Sema5a uc007vku.1 uc007vku.2 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane semaphorin receptor binding uc007vku.1 uc007vku.2 
ENSMUST00000067468.6 Gm4793 ENSMUST00000067468.6 Gm4793 (from geneSymbol) AK044378 ENSMUST00000067468.1 ENSMUST00000067468.2 ENSMUST00000067468.3 ENSMUST00000067468.4 ENSMUST00000067468.5 uc007ctm.1 uc007ctm.2 uc007ctm.3 uc007ctm.1 uc007ctm.2 uc007ctm.3 
ENSMUST00000067469.6 Tmem74 ENSMUST00000067469.6 transmembrane protein 74 (from RefSeq NM_175502.3) ENSMUST00000067469.1 ENSMUST00000067469.2 ENSMUST00000067469.3 ENSMUST00000067469.4 ENSMUST00000067469.5 NM_175502 Q8BQU7 TMM74_MOUSE uc007vpn.1 uc007vpn.2 uc007vpn.3 Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction (By similarity). Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein Belongs to the TMEM74 family. autophagosome membrane molecular_function cellular_component lysosome lysosomal membrane autophagy membrane integral component of membrane macroautophagy cytoplasmic vesicle uc007vpn.1 uc007vpn.2 uc007vpn.3 
ENSMUST00000067476.9 Spcs3 ENSMUST00000067476.9 signal peptidase complex subunit 3 homolog (S. cerevisiae) (from RefSeq NM_029701.1) ENSMUST00000067476.1 ENSMUST00000067476.2 ENSMUST00000067476.3 ENSMUST00000067476.4 ENSMUST00000067476.5 ENSMUST00000067476.6 ENSMUST00000067476.7 ENSMUST00000067476.8 NM_029701 Q6ZWQ7 Q8C1D0 SPCS3_MOUSE Spcs3 uc033jfo.1 uc033jfo.2 Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity). Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3. Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3. Within the complex, interacts with SEC11A or SEC11C and SPCS1. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Belongs to the SPCS3 family. endoplasmic reticulum signal peptidase complex endoplasmic reticulum membrane signal peptide processing proteolysis peptidase activity membrane integral component of membrane hydrolase activity viral protein processing organelle membrane intracellular membrane-bounded organelle protein targeting to ER uc033jfo.1 uc033jfo.2 
ENSMUST00000067479.6 Cyp3a44 ENSMUST00000067479.6 cytochrome P450, family 3, subfamily a, polypeptide 44 (from RefSeq NM_177380.3) Cyp3a44 ENSMUST00000067479.1 ENSMUST00000067479.2 ENSMUST00000067479.3 ENSMUST00000067479.4 ENSMUST00000067479.5 NM_177380 Q9EQW4 Q9EQW4_MOUSE cyp3a uc009amx.1 uc009amx.2 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence= Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane eripheral membrane protein Membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cellular_component endoplasmic reticulum membrane steroid metabolic process steroid hydroxylase activity retinoic acid 4-hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding demethylase activity intracellular membrane-bounded organelle metal ion binding testosterone 6-beta-hydroxylase activity oxidation-reduction process oxidative demethylation estrogen 16-alpha-hydroxylase activity uc009amx.1 uc009amx.2 
ENSMUST00000067485.4 Slc30a7 ENSMUST00000067485.4 solute carrier family 30 (zinc transporter), member 7 (from RefSeq NM_023214.7) ENSMUST00000067485.1 ENSMUST00000067485.2 ENSMUST00000067485.3 NM_023214 Q80Y27 Q9JKN1 Slc30a7 ZNT7_MOUSE Znt7 Zntl2 uc008rbt.1 uc008rbt.2 uc008rbt.3 Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway (PubMed:12446736, PubMed:17954933). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases (By similarity). Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence=; Homooligomer. Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasmic vesicle Golgi apparatus, trans-Golgi network Sarcoplasmic reticulum Mitochondrion Highly expressed in liver, spleen, duodenum and part of the jejunum of small intestine (at protein level). Moderately expressed in kidney, lung, and brain. Barely detectable in heart (PubMed:12446736, PubMed:17954933). In brain, expressed in cerebellum, cerebral cortex and hippocampus (at protein level) (PubMed:19283665). Homozygous knockout mice are viable, fertile, and display no obvious morphological abnormalities. However, they accumulate less zinc in cells and tissues and have a low body zinc status. This is associated with classic manifestations of dietary zinc deficiency, reduced food intake and poor growth. A decrease in body fat accumulation and reduced zinc absorption in the gut are observed. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. Golgi membrane zinc ion transmembrane transporter activity cytoplasm Golgi apparatus ion transport cation transport zinc II ion transport zinc ion binding cation transmembrane transporter activity membrane integral component of membrane cytoplasmic vesicle vesicle sequestering of zinc ion perinuclear region of cytoplasm transmembrane transport zinc II ion transmembrane transport cation transmembrane transport uc008rbt.1 uc008rbt.2 uc008rbt.3 
ENSMUST00000067492.8 Fabp1 ENSMUST00000067492.8 fatty acid binding protein 1, liver (from RefSeq NM_017399.5) ENSMUST00000067492.1 ENSMUST00000067492.2 ENSMUST00000067492.3 ENSMUST00000067492.4 ENSMUST00000067492.5 ENSMUST00000067492.6 ENSMUST00000067492.7 Fabp1 NM_017399 Q3V2F7 Q3V2F7_MOUSE uc009cgh.1 uc009cgh.2 uc009cgh.3 Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Cytoplasm Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. long-chain fatty acid transporter activity fatty acid binding phospholipid binding nucleus nucleoplasm cytoplasm peroxisomal matrix cytosol drug binding lipid binding long-chain fatty acid transport antioxidant activity positive regulation of fatty acid beta-oxidation bile acid binding macromolecular complex negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process apical cortex intestinal absorption positive regulation of hydrolase activity cellular response to hydrogen peroxide cellular response to hypoxia cellular oxidant detoxification uc009cgh.1 uc009cgh.2 uc009cgh.3 
ENSMUST00000067495.9 Wnt11 ENSMUST00000067495.9 wingless-type MMTV integration site family, member 11, transcript variant 3 (from RefSeq NM_001285794.1) ENSMUST00000067495.1 ENSMUST00000067495.2 ENSMUST00000067495.3 ENSMUST00000067495.4 ENSMUST00000067495.5 ENSMUST00000067495.6 ENSMUST00000067495.7 ENSMUST00000067495.8 NM_001285794 Q059Y4 Q059Y4_MOUSE Wnt11 uc009ikw.1 uc009ikw.2 uc009ikw.3 uc009ikw.4 uc009ikw.5 Ligand for members of the frizzled family of seven transmembrane receptors. Secreted, extracellular space, extracellular matrix Belongs to the Wnt family. GTPase activator activity receptor binding extracellular region cytoplasm protein phosphorylation multicellular organism development positive regulation of gene expression Wnt signaling pathway cell differentiation protein kinase activator activity negative regulation of cell growth adrenal gland development positive regulation of cell migration negative regulation of cell migration response to nutrient levels activation of protein kinase activity protein localization to cell surface negative regulation of apoptotic process positive regulation of GTPase activity transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated embryonic skeletal system development positive regulation of stress fiber assembly cloacal septation lung-associated mesenchyme development negative regulation of cell death ureteric bud morphogenesis neuroendocrine cell differentiation mesonephric duct development positive regulation of protein kinase C signaling negative regulation of canonical Wnt signaling pathway uc009ikw.1 uc009ikw.2 uc009ikw.3 uc009ikw.4 uc009ikw.5 
ENSMUST00000067496.7 Atp5if1 ENSMUST00000067496.7 ATP synthase inhibitory factor subunit 1, transcript variant 2 (from RefSeq NM_007512.5) ATIF1_MOUSE Atp5if1 Atpi Atpif1 ENSMUST00000067496.1 ENSMUST00000067496.2 ENSMUST00000067496.3 ENSMUST00000067496.4 ENSMUST00000067496.5 ENSMUST00000067496.6 If1 NM_007512 O35143 Q9D879 uc290qlt.1 uc290qlt.2 This gene encodes a member of the ATPase inhibitor family of proteins. This protein has been shown to negatively regulate the ATP hydrolysis activity of the F1Fo-ATPase. Knockdown of this gene is associated with reduced heme synthesis in differentiating erythroid cells. Misregulation of this gene has been found to lead to increased aerobic glycolysis in mouse cancer cells, while high expression levels of this gene have been correlated with gastric and liver cancer severity in human patients. A pseudogene of this gene has been identified. [provided by RefSeq, Apr 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase (By similarity). Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme (PubMed:23135403). Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0 (By similarity). Mitochondrion Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil composed of residues 74-106, leaving each N-terminal inhibitory region (residues 26-52) accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region (residues 26-52) binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity (By similarity). Belongs to the ATPase inhibitor family. negative regulation of endothelial cell proliferation protein binding calmodulin binding mitochondrion heme biosynthetic process cell surface enzyme binding erythrocyte differentiation negative regulation of ATPase activity ATPase inhibitor activity protein homodimerization activity angiostatin binding ATPase binding protein homooligomerization protein homotetramerization negative regulation of hydrolase activity mitochondrial depolarization reactive oxygen species metabolic process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway positive regulation of proteolysis involved in cellular protein catabolic process regulation of protein targeting to mitochondrion regulation of ATP metabolic process positive regulation of mitophagy in response to mitochondrial depolarization uc290qlt.1 uc290qlt.2 
ENSMUST00000067505.15 Tmem120b ENSMUST00000067505.15 transmembrane protein 120B, transcript variant 5 (from RefSeq NR_185160.1) ENSMUST00000067505.1 ENSMUST00000067505.10 ENSMUST00000067505.11 ENSMUST00000067505.12 ENSMUST00000067505.13 ENSMUST00000067505.14 ENSMUST00000067505.2 ENSMUST00000067505.3 ENSMUST00000067505.4 ENSMUST00000067505.5 ENSMUST00000067505.6 ENSMUST00000067505.7 ENSMUST00000067505.8 ENSMUST00000067505.9 NR_185160 Q14BK6 Q3TA38 Q8R243 T120B_MOUSE Tmem120b uc008znc.1 uc008znc.2 uc008znc.3 Necessary for efficient adipogenesis (PubMed:26024229). Does not show ion channel activity (PubMed:32084332). Heterooligomer with TMEM120A. Nucleus inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TA38-1; Sequence=Displayed; Name=2; IsoId=Q3TA38-2; Sequence=VSP_029233; Expressed in inguinal and subcutaneous white adipose tissue and in brown adipose tissue. Up-regulated during adipocyte differentiation. Belongs to the TMEM120 family. molecular_function nucleus nuclear inner membrane membrane integral component of membrane fat cell differentiation protein heterooligomerization uc008znc.1 uc008znc.2 uc008znc.3 
ENSMUST00000067512.8 Smpd3 ENSMUST00000067512.8 sphingomyelin phosphodiesterase 3, neutral (from RefSeq NM_021491.4) ENSMUST00000067512.1 ENSMUST00000067512.2 ENSMUST00000067512.3 ENSMUST00000067512.4 ENSMUST00000067512.5 ENSMUST00000067512.6 ENSMUST00000067512.7 NM_021491 NSMA2_MOUSE Q3UTQ5 Q9JJY3 Smpd3 uc009nfy.1 uc009nfy.2 Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:15051724, PubMed:15764706, PubMed:15929065, PubMed:16025116). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location (PubMed:21550973). May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:295975; EC=3.1.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19254; Evidence=; Reaction=H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine = H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine; Xref=Rhea:RHEA:45320, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74450, ChEBI:CHEBI:74535, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45321; Evidence=; Reaction=H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine; Xref=Rhea:RHEA:45324, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72965, ChEBI:CHEBI:83360, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45325; Evidence=; Reaction=H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-hexadecanoylsphing-4-enine + phosphocholine; Xref=Rhea:RHEA:45644, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72959, ChEBI:CHEBI:78646, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45645; Evidence=; Reaction=an N-(acyl)-sphingosylphosphocholine + H2O = an N-acyl- sphingoid base + H(+) + phosphocholine; Xref=Rhea:RHEA:45300, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64583, ChEBI:CHEBI:83273, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45301; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:75542, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41120; Evidence=; Reaction=1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O- octadecyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:39923, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74001, ChEBI:CHEBI:75216, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39924; Evidence=; Reaction=a sphingosylphosphocholine + H2O = a sphingoid base + H(+) + phosphocholine; Xref=Rhea:RHEA:45296, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:84410, ChEBI:CHEBI:85171, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45297; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by nSMase inhibitor GW4869. Binding of anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) increases enzymatic activity (PubMed:21550973). Lipid metabolism; sphingolipid metabolism. Q9JJY3; O75530: EED; Xeno; NbExp=5; IntAct=EBI-9817007, EBI-923794; Q9JJY3; P10809: HSPD1; Xeno; NbExp=3; IntAct=EBI-9817007, EBI-352528; Golgi apparatus membrane ; Lipid-anchor Cell membrane ; Lipid- anchor Note=May localize to detergent- resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons (PubMed:15764706). Predominantly expressed in brain (at protein level). Palmitoylated, palmitoylation-deficient proteins are targeted for lysosomal degradation. Defects in smpd3 are the cause of fragilitas ossium (fro) mutation characterized by severe osteogenesis and dentinogenesis imperfecta with no detectable collagen defect. Mice lacking Smpd2 and Smpd3 are completely devoid of neutral SMase activity but do not developed sphingomyelin storage abnormalities. Mice lacking Smpd3 develop a form of dwarfism and delayed puberty as part of a hypothalamus-induced combined pituitary hormone deficiency (CPHD). Growth retardation is probably due to delayed ossification of long bones. Belongs to the neutral sphingomyelinase family. Golgi cis cisterna Golgi membrane skeletal system development ossification regulation of protein phosphorylation endochondral ossification chondrocyte development hematopoietic progenitor cell differentiation regulation of leukocyte migration chondrocyte development involved in endochondral bone morphogenesis phospholipase activity sphingomyelin phosphodiesterase activity protein binding cytoplasm Golgi apparatus plasma membrane lipid metabolic process sphingolipid metabolic process ceramide metabolic process sphingomyelin metabolic process sphingomyelin catabolic process cell cycle signal transduction multicellular organism development artery smooth muscle contraction polysaccharide transport membrane hydrolase activity peptide hormone secretion bone mineralization lung development BMP signaling pathway collagen metabolic process cellular response to reactive oxygen species multicellular organism growth identical protein binding protein kinase B signaling positive regulation of nitric oxide biosynthetic process positive regulation of mitotic nuclear division metal ion binding platelet-derived growth factor receptor signaling pathway lung alveolus development positive regulation of smooth muscle cell proliferation cartilage development negative regulation of cytosolic calcium ion concentration bone development respiratory system development regulation of cartilage development neutral sphingomyelin phosphodiesterase activity cellular response to hydrogen peroxide G1 to G0 transition cellular response to magnesium ion cellular response to tumor necrosis factor cellular response to redox state DNA biosynthetic process extracellular matrix assembly dopamine uptake sphingolipid mediated signaling pathway dentinogenesis bone growth regulation of hyaluronan biosynthetic process negative regulation of hyaluronan biosynthetic process positive regulation of NIK/NF-kappaB signaling cellular response to peptide positive regulation of exosomal secretion positive regulation of ceramide biosynthetic process uc009nfy.1 uc009nfy.2 
ENSMUST00000067523.2 Gm9945 ENSMUST00000067523.2 Gm9945 (from geneSymbol) AK078725 ENSMUST00000067523.1 uc287ycj.1 uc287ycj.2 uc287ycj.1 uc287ycj.2 
ENSMUST00000067529.9 Sytl5 ENSMUST00000067529.9 synaptotagmin-like 5, transcript variant 1 (from RefSeq NM_177704.3) A2AF59 ENSMUST00000067529.1 ENSMUST00000067529.2 ENSMUST00000067529.3 ENSMUST00000067529.4 ENSMUST00000067529.5 ENSMUST00000067529.6 ENSMUST00000067529.7 ENSMUST00000067529.8 NM_177704 Q80T23 Q812E5 SYTL5_MOUSE Slp5 uc009sqa.1 uc009sqa.2 uc009sqa.3 uc009sqa.4 May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids (By similarity). Binds RAB27A that has been activated by GTP-binding. Membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80T23-1; Sequence=Displayed; Name=2; Synonyms=Slp5 delta 5S-I; IsoId=Q80T23-2; Sequence=VSP_007905; protein binding phospholipid binding intracellular protein transport exocytosis membrane Rab GTPase binding metal ion binding exocytic vesicle uc009sqa.1 uc009sqa.2 uc009sqa.3 uc009sqa.4 
ENSMUST00000067530.6 Vapb ENSMUST00000067530.6 vesicle-associated membrane protein, associated protein B and C (from RefSeq NM_019806.6) ENSMUST00000067530.1 ENSMUST00000067530.2 ENSMUST00000067530.3 ENSMUST00000067530.4 ENSMUST00000067530.5 NM_019806 Q8BH80 Q8BH80_MOUSE Vapb uc008oei.1 uc008oei.2 uc008oei.3 uc008oei.4 Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Membrane ; Single-pass type IV membrane protein Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. Golgi membrane cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cellular calcium ion homeostasis ER to Golgi vesicle-mediated transport endoplasmic reticulum organization microtubule binding membrane integral component of membrane modulation by virus of host morphology or physiology enzyme binding endoplasmic reticulum unfolded protein response FFAT motif binding IRE1-mediated unfolded protein response protein homodimerization activity positive regulation of viral genome replication protein heterodimerization activity beta-tubulin binding COPII-coated vesicle budding uc008oei.1 uc008oei.2 uc008oei.3 uc008oei.4 
ENSMUST00000067532.11 Ms4a7 ENSMUST00000067532.11 membrane-spanning 4-domains, subfamily A, member 7, transcript variant 1 (from RefSeq NM_027836.6) ENSMUST00000067532.1 ENSMUST00000067532.10 ENSMUST00000067532.2 ENSMUST00000067532.3 ENSMUST00000067532.4 ENSMUST00000067532.5 ENSMUST00000067532.6 ENSMUST00000067532.7 ENSMUST00000067532.8 ENSMUST00000067532.9 Ms4a7 NM_027836 Q99N04 Q99N04_MOUSE uc008grz.1 uc008grz.2 uc008grz.3 uc008grz.4 uc008grz.5 Belongs to the MS4A family. molecular_function cellular_component biological_process membrane integral component of membrane uc008grz.1 uc008grz.2 uc008grz.3 uc008grz.4 uc008grz.5 
ENSMUST00000067538.6 Ptprs ENSMUST00000067538.6 protein tyrosine phosphatase receptor type S, transcript variant 1 (from RefSeq NM_011218.2) B0V2N1 ENSMUST00000067538.1 ENSMUST00000067538.2 ENSMUST00000067538.3 ENSMUST00000067538.4 ENSMUST00000067538.5 NM_011218 PTPRS_MOUSE Q3TEC3 Q3TXC9 Q4JFC7 Q5XJV4 Q64503 Q64699 Q7TT17 uc008dby.1 uc008dby.2 uc008dby.3 uc008dby.4 Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:19833921, PubMed:21454754, PubMed:22406547). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (PubMed:21454754). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:15797710, PubMed:19833921, PubMed:19780196, PubMed:21454754, PubMed:22519304, PubMed:22406547). Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2 (PubMed:21454754). Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (PubMed:10080191). Functions as a tyrosine phosphatase (PubMed:7529177). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (PubMed:15797710). Down-regulates TLR9-mediated activation of NF-kappa- B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Binding to large heparan sulfate proteoglycan structures promotes oligomerization (PubMed:21454754). Binding to chondroitin sulfate proteoglycan does not lead to oligomerization (PubMed:21454754). Interacts (via Ig-like domains) with NTRK3 (PubMed:25385546). Interacts (via Ig-like domains) with NTRK1, but does not form detectable complexes with NTRK2 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3 (By similarity). Cell membrane ; Single-pass type I membrane protein Cell projection, axon Perikaryon Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Synapse, synaptosome Postsynaptic density Cell projection, neuron projection Cell projection, growth cone Note=Is rapidly internalized when dendritic cells are stimulated with the TLR9 ligand cytidine-phosphate- guanosine (CpG) (PubMed:26231120). Detected in a punctate pattern along neurites and axon growth cones (PubMed:21454754). Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=B0V2N1-1; Sequence=Displayed; Name=2; IsoId=B0V2N1-2; Sequence=VSP_036062; Name=3; IsoId=B0V2N1-3; Sequence=VSP_036058, VSP_036059; Name=4; IsoId=B0V2N1-4; Sequence=VSP_036058, VSP_036059, VSP_036061; Name=5; IsoId=B0V2N1-5; Sequence=VSP_036057; Name=6; IsoId=B0V2N1-6; Sequence=VSP_036060; Detected in brain cortex, cerebellum and thoracic spinal cord (at protein level) (PubMed:19780196, PubMed:22519304). Detected in motor cortex and white matter of the spinal cord, but not in spinal cord gray matter (PubMed:19780196). Isoform 1 and isoform 6 are predominantly expressed in the brain (cerebrum and cerebellum) and to a lesser extent in the heart and skeletal muscle. Also found in neuronal-derived cell lines (PubMed:7529177). Detected in the ganglion cell layer of the retina and in glial cells along the optic nerve (PubMed:15797710). Detected in bone marrow and spleen plasmacytoid dendritic cells (PubMed:26231120). Expression is seen in embryos between 8 dpc and 16 dpc and a peak expression is seen at 14 dpc. A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity). Mating heterozygous mice gives rise to Ptprs deficient mice at the expected Mendelian rate, but the pups are somewhat lighter than their littermates at birth and display strongly impaired weight gain (PubMed:10080191). After about three weeks, mutant mice weigh only 50 to 55% of normal littermates, possibly due to reduced Igf1 levels in blood serum (PubMed:10080191). Pups born after crossing Ptprs deficient mice display about 41% lethality during the first day after birth (PubMed:10080191). Adult mutants have a reduced overall brain size, with a dramatic decrease in the size of the olfactory bulb (PubMed:10080191). As a consequence, mutant mice have strongly impaired ability to perceive repellent smells (PubMed:10080191). Females are less often in estrus (PubMed:10080191). Besides, mutant mice display a decreased overall size of the pituitary glands; relative to the total size, the intermediary lobe is enlarged with a concomitant decrease in the size of the anterior and posterior lobes (PubMed:10080191). Likewise, the size of the hypothalamus is decreased (PubMed:10080191). No visible effect on the structure of the retina and the optic nerve (PubMed:15797710). Mutant mice show increased axon outgrowth from retinal ganglion cells after optic nerve transection (PubMed:15797710). Mutant mice display increased axon outgrowth after spinal cord injury (PubMed:19833921, PubMed:19780196). In aging mice, mossy fibers in the CA3C region of the hippocampus show increased sprouting (PubMed:22519304). No difference in mossy fiber sprouting is seen in the CA3A region of the hippocampus (PubMed:22519304). After kainate-induced seizures, mutant mice show increased mossy fiber sprouting in both the CA3C and the CA3A region of the hippocampus (PubMed:22519304). Mutant mice display a slight increase in dendrite length and dendrite spine density in pyramidal cells in the CA1 region of the hippocampus, and subtle changes in miniature AMPAR-mediated excitatory post-synaptic currents (PubMed:22519304). Dorsal root ganglion neurons from mutant mice show decreased stimulation of neurite outgrowth in response to the heparan sulfate proteoglycan GPC2 (PubMed:21454754). Cerebellar granule neurons and dorsal root ganglion neurons from mutant mice show decreased inhibition of neurite outgrowth in response to chondroitin sulfate proteoglycan (PubMed:19833921, PubMed:19780196, PubMed:21454754, PubMed:22406547). Sensory neurons show increased axon outgrowth after spinal cord crush injury (PubMed:19833921). After optic nerve crush injury, mutant mice show no increase in axon regeneration (PubMed:22406547). Combined disruption of Rtn4r, Rtn4rl1 and Ptprs increases axon regeneration after injury (PubMed:22406547). Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding plasma membrane protein dephosphorylation cell adhesion heparin binding negative regulation of neuron projection development postsynaptic density membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity spinal cord development cerebellum development hippocampus development cerebral cortex development corpus callosum development cell junction integral component of synaptic vesicle membrane axon negative regulation of axon extension synaptic vesicle membrane cytoplasmic vesicle negative regulation of interferon-alpha production negative regulation of interferon-beta production negative regulation of toll-like receptor 9 signaling pathway peptidyl-tyrosine dephosphorylation chondroitin sulfate binding cell projection neuron projection perikaryon heparan sulfate proteoglycan binding synapse postsynaptic membrane negative regulation of collateral sprouting negative regulation of axon regeneration modulation of synaptic transmission synapse organization negative regulation of dendritic spine development establishment of endothelial intestinal barrier glutamatergic synapse integral component of presynaptic membrane integral component of postsynaptic density membrane synaptic membrane adhesion regulation of presynapse assembly uc008dby.1 uc008dby.2 uc008dby.3 uc008dby.4 
ENSMUST00000067539.4 Tas2r109 ENSMUST00000067539.4 taste receptor, type 2, member 109 (from RefSeq NM_207017.1) ENSMUST00000067539.1 ENSMUST00000067539.2 ENSMUST00000067539.3 NM_207017 Q7M707 T2r62 TR109_MOUSE Tas2r109 uc009ejx.1 uc009ejx.2 Putative taste receptor which may play a role in the perception of bitterness. Membrane ; Multi-pass membrane protein Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009ejx.1 uc009ejx.2 
ENSMUST00000067543.8 Trib1 ENSMUST00000067543.8 tribbles pseudokinase 1 (from RefSeq NM_144549.4) ENSMUST00000067543.1 ENSMUST00000067543.2 ENSMUST00000067543.3 ENSMUST00000067543.4 ENSMUST00000067543.5 ENSMUST00000067543.6 ENSMUST00000067543.7 NM_144549 Q8BFS7 Q8BJR9 Q8BZX3 Q8K4K4 Q91W04 TRIB1_MOUSE Trb1 Trib1 uc007vxx.1 uc007vxx.2 uc007vxx.3 Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:23515163, PubMed:20410507). Promotes CEBPA degradation and inhibits its function (PubMed:20410507). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (PubMed:24003916, PubMed:23515163). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (PubMed:23515163). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (By similarity). Monomer. Interacts (via protein kinase domain) with CEBPA. Interacts with COP1. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8K4K4-1; Sequence=Displayed; Name=2 ; IsoId=Q8K4K4-2; Sequence=VSP_051888; The COP1-binding motif (355-360) is required for regulation activity (PubMed:24003916). The C-terminus (351-372) is required for interaction with COP1 (By similarity). The protein kinase active site is incompatible with ATP binding and is inactive (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. Sequence=BAC28245.1; Type=Erroneous initiation; Evidence=; Sequence=BAC37854.1; Type=Erroneous initiation; Evidence=; protein kinase inhibitor activity nucleus cytoplasm negative regulation of protein kinase activity JNK cascade transcription factor binding negative regulation of smooth muscle cell migration mitogen-activated protein kinase kinase binding ubiquitin protein ligase binding negative regulation of lipopolysaccharide-mediated signaling pathway positive regulation of proteasomal ubiquitin-dependent protein catabolic process response to lipopolysaccharide regulation of MAP kinase activity negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of eosinophil differentiation positive regulation of macrophage differentiation negative regulation of neutrophil differentiation negative regulation of smooth muscle cell proliferation positive regulation of ubiquitin-protein transferase activity ubiquitin-protein transferase regulator activity protein kinase activity ATP binding protein phosphorylation uc007vxx.1 uc007vxx.2 uc007vxx.3 
ENSMUST00000067545.8 Lclat1 ENSMUST00000067545.8 lysocardiolipin acyltransferase 1, transcript variant 3 (from RefSeq NM_001177968.1) Agpat8 Alcat1 ENSMUST00000067545.1 ENSMUST00000067545.2 ENSMUST00000067545.3 ENSMUST00000067545.4 ENSMUST00000067545.5 ENSMUST00000067545.6 ENSMUST00000067545.7 Gm91 LCLT1_MOUSE Lycat NM_001177968 Q3UN02 uc008dnh.1 uc008dnh.2 uc008dnh.3 uc008dnh.4 uc008dnh.5 Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (PubMed:15152008). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (PubMed:15152008). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol- 3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn- glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Possesses lysophosphatidylinositol acyltransferase (LPIAT) activity (PubMed:20668164). Possesses lysophosphatidylglycerol acyltransferase (LPGAT) activity (By similarity). Required for establishment of the hematopoietic and endothelial lineages (PubMed:17675553). Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19710; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:33195, ChEBI:CHEBI:57287, ChEBI:CHEBI:57880, ChEBI:CHEBI:58342, ChEBI:CHEBI:64771; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33196; Evidence=; Reaction=1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:33203, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64716, ChEBI:CHEBI:64840; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33204; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:33187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57518, ChEBI:CHEBI:64839; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33188; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74544, ChEBI:CHEBI:74546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37132; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero- 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn- glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37135, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74547, ChEBI:CHEBI:74548; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37136; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn- glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)- octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37139, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74549, ChEBI:CHEBI:74550; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37140; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37143, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74544, ChEBI:CHEBI:74551; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37144; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37147, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:74544, ChEBI:CHEBI:74552; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37148; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn- glycerol) = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn- glycerol) + CoA; Xref=Rhea:RHEA:37619, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:64840, ChEBI:CHEBI:75173; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37620; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo- inositol) = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D- myo-inositol) + CoA; Xref=Rhea:RHEA:37623, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:64771, ChEBI:CHEBI:75116; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37624; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo- inositol) + CoA; Xref=Rhea:RHEA:35871, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72833, ChEBI:CHEBI:72835; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35872; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3- phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:35875, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:72833, ChEBI:CHEBI:72836; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35876; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho- (1D-myo-inositol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:35879, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72833, ChEBI:CHEBI:72837; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35880; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:35883, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:72833, ChEBI:CHEBI:72838; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35884; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn- glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA; Xref=Rhea:RHEA:35867, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:72833, ChEBI:CHEBI:72834; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35868; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn- glycerol) + CoA; Xref=Rhea:RHEA:35851, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72829, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35852; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3- phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35887, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:72839, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35888; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho- (1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35891, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72841, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35892; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)- sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35895, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:72840, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35896; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho- (1'-sn-glycerol) = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37643, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72826, ChEBI:CHEBI:75161; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37644; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho- (1'-sn-glycerol) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37647, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72827, ChEBI:CHEBI:72845; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37648; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phospho-(1'-sn-glycerol) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37651, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72828, ChEBI:CHEBI:75163; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37652; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho- (1D-myo-inositol) + CoA; Xref=Rhea:RHEA:37639, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:72833, ChEBI:CHEBI:75160; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37640; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3- phospho]-glycerol = 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3- phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37615, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75137, ChEBI:CHEBI:75139; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37616; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3- phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl- sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3- phospho]-glycerol + CoA; Xref=Rhea:RHEA:37611, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:64743, ChEBI:CHEBI:75140; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37612; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3- phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl- sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn- glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37675, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:64743, ChEBI:CHEBI:75205; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37676; Evidence=; Reaction=1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3- phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3- phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37679, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:64743, ChEBI:CHEBI:75203; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37680; Evidence=; Reaction=1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl- CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2- hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37683, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:75137, ChEBI:CHEBI:75201; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37684; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1- acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37427, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57970, ChEBI:CHEBI:74917; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37428; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3- phospho]-glycerol = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero- 3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37687, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:75137, ChEBI:CHEBI:75209; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37688; Evidence=; Reaction=1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3- phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37691, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75137, ChEBI:CHEBI:75207; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37692; Evidence=; Reaction=1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3- phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37695, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:75137, ChEBI:CHEBI:75208; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37696; Evidence=; Reaction=1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3- phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3- phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:38623, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:64743, ChEBI:CHEBI:75990; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38624; Evidence=; Reaction=1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl- CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2- hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:38627, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:75137, ChEBI:CHEBI:75993; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38628; Evidence=; Reaction=1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3- phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3- phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:38631, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:64743, ChEBI:CHEBI:75994; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38632; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn- glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'- [1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:38635, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:64743, ChEBI:CHEBI:75995; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38636; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn- glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn- glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:38639, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:75137, ChEBI:CHEBI:75996; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38640; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D- myo-inositol) + CoA; Xref=Rhea:RHEA:43960, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:64771, ChEBI:CHEBI:83939; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43961; Evidence=; Reaction=a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl- CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA; Xref=Rhea:RHEA:43964, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:64872, ChEBI:CHEBI:65055; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43965; Evidence=; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 2/3. Endoplasmic reticulum membrane ; Multi-pass membrane protein Widely expressed with highest expression in heart, liver and 12.5 dpc aorta-gonad-mesonephros and lower levels in the 16 dpc fetal liver and adult bone marrow. In bone marrow, highest levels are found in B-cells compared with whole bone marrow, T-cells, erythrocytes, and granulocytes. The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. 1-acylglycerol-3-phosphate O-acyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane cytosol lipid metabolic process multicellular organism development phospholipid biosynthetic process membrane integral component of membrane CDP-diacylglycerol biosynthetic process transferase activity transferase activity, transferring acyl groups cardiolipin acyl-chain remodeling phosphatidylinositol acyl-chain remodeling uc008dnh.1 uc008dnh.2 uc008dnh.3 uc008dnh.4 uc008dnh.5 
ENSMUST00000067549.15 Zfp219 ENSMUST00000067549.15 zinc finger protein 219, transcript variant 1 (from RefSeq NM_027248.2) ENSMUST00000067549.1 ENSMUST00000067549.10 ENSMUST00000067549.11 ENSMUST00000067549.12 ENSMUST00000067549.13 ENSMUST00000067549.14 ENSMUST00000067549.2 ENSMUST00000067549.3 ENSMUST00000067549.4 ENSMUST00000067549.5 ENSMUST00000067549.6 ENSMUST00000067549.7 ENSMUST00000067549.8 ENSMUST00000067549.9 NM_027248 Q6IQX8 Q921W9 Q924S6 Q9CVF3 ZN219_MOUSE Zfp219 Znf219 uc007tnx.1 uc007tnx.2 uc007tnx.3 uc007tnx.4 uc007tnx.5 Transcriptional regulator (PubMed:20940257). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:20940257). Binds to the HMGN1 promoter and may repress HMGN1 expression (By similarity). Regulates SNCA expression in primary cortical neurons (By similarity). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (PubMed:20940257). Plays a role in chondrocyte differentiation (PubMed:20940257). Interacts with SOX9 (via C-terminus). Nucleus Highly expressed in primary chondrocytes, heart, pancreas and testis. Expressed in proliferating chondrocytes in the tibia at embryonic stage 15.5 dpc (at protein level). Expressed in limb buds at stage 11.5 dpc, where it colocalizes with Col2a1 and Sox9. C2H2-type zinc-finger domains 5 and 6 are important for the interaction with SOX9. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription, DNA-templated regulation of transcription, DNA-templated cell differentiation positive regulation of chondrocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding limb bud formation uc007tnx.1 uc007tnx.2 uc007tnx.3 uc007tnx.4 uc007tnx.5 
ENSMUST00000067556.4 4930503L19Rik ENSMUST00000067556.4 RIKEN cDNA 4930503L19 gene, transcript variant 6 (from RefSeq NR_166658.1) ENSMUST00000067556.1 ENSMUST00000067556.2 ENSMUST00000067556.3 LAS2_MOUSE Las2 NR_166658 Q8BNS5 Q8C2X0 Q8CB14 uc008fod.1 uc008fod.2 Might play a role in cell proliferation. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CB14-1; Sequence=Displayed; Name=2; IsoId=Q8CB14-4; Sequence=VSP_015086, VSP_015087; Widely expressed with highest levels in lung and spleen. Also expressed during embryonic development, at least from 7 to 17 dpc. extracellular region negative regulation of cell proliferation uc008fod.1 uc008fod.2 
ENSMUST00000067563.9 Ntaq1 ENSMUST00000067563.9 N-terminal glutamine amidase 1, transcript variant 1 (from RefSeq NM_029734.2) ENSMUST00000067563.1 ENSMUST00000067563.2 ENSMUST00000067563.3 ENSMUST00000067563.4 ENSMUST00000067563.5 ENSMUST00000067563.6 ENSMUST00000067563.7 ENSMUST00000067563.8 NM_029734 NTAQ1_MOUSE Q80WB5 Wdyhv1 uc007vti.1 uc007vti.2 uc007vti.3 uc007vti.4 Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. Reaction=H2O + N-terminal L-glutaminyl-[protein] = N-terminal L- glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:50680, Rhea:RHEA- COMP:12668, Rhea:RHEA-COMP:12777, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:64721, ChEBI:CHEBI:64722; EC=3.5.1.122; Evidence=; Monomer. Cytoplasm, cytosol Nucleus Widely expressed. Belongs to the NTAQ1 family. nucleus cytoplasm cytosol cellular protein modification process protein-N-terminal asparagine amidohydrolase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides protein catabolic process protein-N-terminal glutamine amidohydrolase activity uc007vti.1 uc007vti.2 uc007vti.3 uc007vti.4 
ENSMUST00000067567.5 Lypla2 ENSMUST00000067567.5 lysophospholipase 2, transcript variant 5 (from RefSeq NR_185005.1) ENSMUST00000067567.1 ENSMUST00000067567.2 ENSMUST00000067567.3 ENSMUST00000067567.4 LYPA2_MOUSE NR_185005 Q3TJD6 Q9WTL7 uc008vhn.1 uc008vhn.2 uc008vhn.3 Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (By similarity). Deacylates GAP43 (By similarity). Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (PubMed:10064901). Hydrolyzes prostaglandin glycerol esters (PG-Gs) (PubMed:25301951). Hydrolyzes PG-Gs in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha- glycerol ester (PGF2-alpha-G) (By similarity). Hydrolyzes 1- arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (By similarity). Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; EC=3.1.2.22; Evidence=; Reaction=H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2; Xref=Rhea:RHEA:48296, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:90230, ChEBI:CHEBI:606564; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48297; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + octadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40887, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:25629, ChEBI:CHEBI:73858; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40888; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphate + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:49092, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57518, ChEBI:CHEBI:57597; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49093; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O = H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine; Xref=Rhea:RHEA:44552, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64765, ChEBI:CHEBI:75020; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44553; Evidence=; Cytoplasm Ubiquitous; detected at low levels. Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. protein depalmitoylation cytoplasm Golgi stack lipid metabolic process fatty acid metabolic process palmitoyl-(protein) hydrolase activity hydrolase activity carboxylic ester hydrolase activity uc008vhn.1 uc008vhn.2 uc008vhn.3 
ENSMUST00000067582.14 Tmem62 ENSMUST00000067582.14 transmembrane protein 62 (from RefSeq NM_175285.4) A2AQ55 ENSMUST00000067582.1 ENSMUST00000067582.10 ENSMUST00000067582.11 ENSMUST00000067582.12 ENSMUST00000067582.13 ENSMUST00000067582.2 ENSMUST00000067582.3 ENSMUST00000067582.4 ENSMUST00000067582.5 ENSMUST00000067582.6 ENSMUST00000067582.7 ENSMUST00000067582.8 ENSMUST00000067582.9 NM_175285 Q8BXJ9 TMM62_MOUSE uc008lxe.1 uc008lxe.2 uc008lxe.3 uc008lxe.4 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane hydrolase activity uc008lxe.1 uc008lxe.2 uc008lxe.3 uc008lxe.4 
ENSMUST00000067597.5 Tas2r130 ENSMUST00000067597.5 taste receptor, type 2, member 130 (from RefSeq NM_199156.1) ENSMUST00000067597.1 ENSMUST00000067597.2 ENSMUST00000067597.3 ENSMUST00000067597.4 NM_199156 P59530 Q0VE81 Q7M726 TA2R7_MOUSE Tas2r6 Tas2r7 uc009eiv.1 uc009eiv.2 uc009eiv.3 Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Membrane; Multi-pass membrane protein. Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in gastric and duodenal tissues. Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009eiv.1 uc009eiv.2 uc009eiv.3 
ENSMUST00000067602.5 Ncam2 ENSMUST00000067602.5 neural cell adhesion molecule 2, transcript variant 1 (from RefSeq NM_001113208.1) ENSMUST00000067602.1 ENSMUST00000067602.2 ENSMUST00000067602.3 ENSMUST00000067602.4 NCAM2_MOUSE NM_001113208 O35136 O35962 Ocam Q0VF23 Rncam uc007ztb.1 uc007ztb.2 uc007ztb.3 uc007ztb.4 uc007ztb.5 May play important roles in selective fasciculation and zone- to-zone projection of the primary olfactory axons. [Isoform Long]: Cell membrane; Single-pass type I membrane protein. [Isoform Short]: Cell membrane; Lipid-anchor, GPI-anchor. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=O35136-1; Sequence=Displayed; Name=Short; IsoId=O35136-2; Sequence=VSP_002590; Expressed in subsets of both olfactory and vomeronasal neurons in a zone-specific manner. plasma membrane cell adhesion axonal fasciculation sensory perception of smell membrane integral component of membrane nuclear body axon anchored component of membrane identical protein binding uc007ztb.1 uc007ztb.2 uc007ztb.3 uc007ztb.4 uc007ztb.5 
ENSMUST00000067620.12 Chdh ENSMUST00000067620.12 choline dehydrogenase, transcript variant 3 (from RefSeq NM_172264.2) CHDH_MOUSE ENSMUST00000067620.1 ENSMUST00000067620.10 ENSMUST00000067620.11 ENSMUST00000067620.2 ENSMUST00000067620.3 ENSMUST00000067620.4 ENSMUST00000067620.5 ENSMUST00000067620.6 ENSMUST00000067620.7 ENSMUST00000067620.8 ENSMUST00000067620.9 NM_172264 Q3TPY4 Q8BJ64 Q8CHT7 uc007sup.1 uc007sup.2 uc007sup.3 uc007sup.4 Reaction=A + choline = AH2 + betaine aldehyde; Xref=Rhea:RHEA:17433, ChEBI:CHEBI:13193, ChEBI:CHEBI:15354, ChEBI:CHEBI:15710, ChEBI:CHEBI:17499; EC=1.1.99.1; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. Mitochondrion inner membrane Acetylation of Lys-498 is observed in liver mitochondria from fasted mice but not from fed mice. Decreased testicular betaine and increased choline and phosphatidylcholine concentrations. Only one of eleven males was able to reproduce, impaired fertility was due to diminished sperm motility. Belongs to the GMC oxidoreductase family. mitochondrion mitochondrial inner membrane choline dehydrogenase activity membrane oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors glycine betaine biosynthetic process from choline flavin adenine dinucleotide binding oxidation-reduction process uc007sup.1 uc007sup.2 uc007sup.3 uc007sup.4 
ENSMUST00000067625.9 Glrp1 ENSMUST00000067625.9 glutamine repeat protein 1 (from RefSeq NM_008132.2) E9Q9S8 E9Q9S8_MOUSE ENSMUST00000067625.1 ENSMUST00000067625.2 ENSMUST00000067625.3 ENSMUST00000067625.4 ENSMUST00000067625.5 ENSMUST00000067625.6 ENSMUST00000067625.7 ENSMUST00000067625.8 Glrp1 NM_008132 uc007byr.1 uc007byr.2 negative regulation of transcription from RNA polymerase II promoter molecular_function nucleus uc007byr.1 uc007byr.2 
ENSMUST00000067628.4 Atad3aos ENSMUST00000067628.4 Atad3aos (from geneSymbol) AK078249 ENSMUST00000067628.1 ENSMUST00000067628.2 ENSMUST00000067628.3 uc012dqx.1 uc012dqx.2 uc012dqx.3 uc012dqx.4 uc012dqx.1 uc012dqx.2 uc012dqx.3 uc012dqx.4 
ENSMUST00000067630.13 Dram2 ENSMUST00000067630.13 DNA-damage regulated autophagy modulator 2, transcript variant 2 (from RefSeq NM_026013.3) DRAM2_MOUSE ENSMUST00000067630.1 ENSMUST00000067630.10 ENSMUST00000067630.11 ENSMUST00000067630.12 ENSMUST00000067630.2 ENSMUST00000067630.3 ENSMUST00000067630.4 ENSMUST00000067630.5 ENSMUST00000067630.6 ENSMUST00000067630.7 ENSMUST00000067630.8 ENSMUST00000067630.9 NM_026013 Q9CR48 Q9D520 Tmem77 uc008qwd.1 uc008qwd.2 uc008qwd.3 uc008qwd.4 Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1. Lysosome membrane ; Multi-pass membrane protein Photoreceptor inner segment Apical cell membrane Note=Localized to photoreceptor inner segments and to the apical surface of retinal pigment epithelial cells. Expressed in the retina. Belongs to the DRAM/TMEM150 family. photoreceptor inner segment molecular_function cytoplasm lysosome lysosomal membrane Golgi apparatus plasma membrane autophagy apoptotic process visual perception regulation of autophagy membrane integral component of membrane apical plasma membrane intracellular membrane-bounded organelle photoreceptor cell maintenance uc008qwd.1 uc008qwd.2 uc008qwd.3 uc008qwd.4 
ENSMUST00000067632.4 Trim65 ENSMUST00000067632.4 tripartite motif-containing 65 (from RefSeq NM_178802.4) A2A867 ENSMUST00000067632.1 ENSMUST00000067632.2 ENSMUST00000067632.3 NM_178802 Q6PGD3 Q8BFW4 TRI65_MOUSE uc007mkb.1 uc007mkb.2 uc007mkb.3 uc007mkb.4 E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation (PubMed:31310649, PubMed:34512673). Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein involved in RNA- mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs. This ubiquitination results in the suppressed expression of miR-138-5p leading to increased autophagy (By similarity). Upon enteroviral infection, promotes 'Lys-63'-mediated ubiquitination activation of IFIH1/MDA5 leading to innate signaling cascade. Mechanistically, selectively recognizes MDA5 filaments that occur on dsRNAs (By similarity). Plays also a role in limitation of inflammation through different mechanisms. First, promotes 'Lys-48'- mediated ubiquitination of VCAM1 leading to its degradation and limitation of LPS-induced lung inflammation (PubMed:31310649). In addition, negatively regulates inflammasome activation by promoting 'lys48'-linked ubiquitination of NLRP3 which is critical for the inhibition of NLRP3 inflammasome activation in resting macrophages (PubMed:34512673). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homo-multimerizes. Interacts with ARRDC4. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BFW4-1; Sequence=Displayed; Name=2; IsoId=Q8BFW4-2; Sequence=VSP_020368, VSP_020369; TRIM65-deficient mice show impaired NLRP3 ubiquitination and enhanced NLRP3 inflammasome activation. Belongs to the TRIM/RBCC family. molecular_function nucleus nucleoplasm cytosol zinc ion binding positive regulation of autophagy metal ion binding uc007mkb.1 uc007mkb.2 uc007mkb.3 uc007mkb.4 
ENSMUST00000067638.14 Sh3bp2 ENSMUST00000067638.14 SH3-domain binding protein 2, transcript variant 1 (from RefSeq NM_011893.3) ENSMUST00000067638.1 ENSMUST00000067638.10 ENSMUST00000067638.11 ENSMUST00000067638.12 ENSMUST00000067638.13 ENSMUST00000067638.2 ENSMUST00000067638.3 ENSMUST00000067638.4 ENSMUST00000067638.5 ENSMUST00000067638.6 ENSMUST00000067638.7 ENSMUST00000067638.8 ENSMUST00000067638.9 NM_011893 Q5U3L0 Q5U3L0_MOUSE Sh3bp2 uc008xcl.1 uc008xcl.2 uc008xcl.3 uc008xcl.4 SH3/SH2 adaptor activity signal transduction positive regulation of signal transduction uc008xcl.1 uc008xcl.2 uc008xcl.3 uc008xcl.4 
ENSMUST00000067646.12 Ilf3 ENSMUST00000067646.12 interleukin enhancer binding factor 3, transcript variant 2 (from RefSeq NM_001042707.2) ENSMUST00000067646.1 ENSMUST00000067646.10 ENSMUST00000067646.11 ENSMUST00000067646.2 ENSMUST00000067646.3 ENSMUST00000067646.4 ENSMUST00000067646.5 ENSMUST00000067646.6 ENSMUST00000067646.7 ENSMUST00000067646.8 ENSMUST00000067646.9 ILF3_MOUSE NM_001042707 Q80VD5 Q812A1 Q8BP80 Q8C2H8 Q8K588 Q9Z1X4 uc009ole.1 uc009ole.2 uc009ole.3 uc009ole.4 The protein encoded by this gene contains two double-stranded RNA binding domains and functions in the post-transcriptional regulation of gene expression. It is a component of an RNA-protein complex that may be involved in mediating the export of messenger RNAs. Alternative splicing results in multiple transcript variants encoding distinct isoforms. These isoforms are grouped into two categories, NFAR-1 or NFAR-2, based on variation at the C-terminus. [provided by RefSeq, Mar 2013]. RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back- splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post- transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with FUS and SMN. Interacts (via C-terminus) with PRMT1. Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80. Forms a heteromeric complex with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5 and ZNF346. Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Interacts with AGO1 and AGO2. Interacts with DHX36; this interaction occurs in a RNA-dependent manner. Interacts with ELAVL1; this interaction occurs in a RNA-dependent manner. Interacts with HAVCR2; this interaction promotes ILF3 ubiquitination and subsequent degradation (By similarity). Nucleus, nucleolus Cytoplasm Nucleus Note=Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Z1X4-1; Sequence=Displayed; Name=2; IsoId=Q9Z1X4-2; Sequence=VSP_013406, VSP_013407, VSP_013408; Name=3; IsoId=Q9Z1X4-3; Sequence=VSP_013406; Ubiquitous. Expressed at high levels in the thymus, testis, ovary and at lower levelss in the spleen. Phosphorylated at Thr-188 and Thr-315 by PKR in response to RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication. Methylated by protein arginine N-methyltransferase 1. Sequence=AAC71052.1; Type=Frameshift; Evidence=; Sequence=BAC36863.1; Type=Frameshift; Evidence=; DNA binding RNA binding double-stranded RNA binding single-stranded RNA binding nucleus nucleoplasm nucleolus cytoplasm mitochondrion protein phosphorylation protein methylation negative regulation of translation enzyme binding mRNA 3'-UTR AU-rich region binding negative regulation of viral genome replication negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated defense response to virus ribonucleoprotein complex uc009ole.1 uc009ole.2 uc009ole.3 uc009ole.4 
ENSMUST00000067663.14 Psmc3 ENSMUST00000067663.14 proteasome (prosome, macropain) 26S subunit, ATPase 3 (from RefSeq NM_008948.2) ENSMUST00000067663.1 ENSMUST00000067663.10 ENSMUST00000067663.11 ENSMUST00000067663.12 ENSMUST00000067663.13 ENSMUST00000067663.2 ENSMUST00000067663.3 ENSMUST00000067663.4 ENSMUST00000067663.5 ENSMUST00000067663.6 ENSMUST00000067663.7 ENSMUST00000067663.8 ENSMUST00000067663.9 NM_008948 O88685 PRS6A_MOUSE Q99JN8 Tbp1 uc008kuf.1 uc008kuf.2 uc008kuf.3 uc008kuf.4 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC3 and few additional components. Interacts with PAAF1. Cytoplasm Nucleus Note=Colocalizes with TRIM5 in cytoplasmic bodies. Belongs to the AAA ATPase family. nucleotide binding proteasome complex P-body blastocyst development ATP binding nucleus cytoplasm proteasome regulatory particle, base subcomplex hydrolase activity proteasome accessory complex protein catabolic process identical protein binding modulation by host of viral transcription positive regulation of RNA polymerase II transcriptional preinitiation complex assembly positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm uc008kuf.1 uc008kuf.2 uc008kuf.3 uc008kuf.4 
ENSMUST00000067664.10 Ywhae ENSMUST00000067664.10 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (from RefSeq NM_009536.4) ENSMUST00000067664.1 ENSMUST00000067664.2 ENSMUST00000067664.3 ENSMUST00000067664.4 ENSMUST00000067664.5 ENSMUST00000067664.6 ENSMUST00000067664.7 ENSMUST00000067664.8 ENSMUST00000067664.9 NM_009536 Q5SS40 Q5SS40_MOUSE Ywhae uc007ket.1 uc007ket.2 uc007ket.3 uc007ket.4 Cytoplasm Belongs to the 14-3-3 family. MAPK cascade monooxygenase activity calcium channel regulator activity nucleus cytoplasm cytosol kinesin complex plasma membrane potassium channel regulator activity enzyme binding protein domain specific binding axon ubiquitin protein ligase binding protein localization to nucleus cellular response to heat identical protein binding histone deacetylase binding ion channel binding macromolecular complex binding synapse positive regulation of protein export from nucleus protein heterodimerization activity phosphoserine binding phosphoprotein binding regulation of cytosolic calcium ion concentration oxidation-reduction process regulation of membrane repolarization central region of growth cone scaffold protein binding glutamatergic synapse regulation of postsynaptic specialization membrane neurotransmitter receptor levels regulation of potassium ion transmembrane transporter activity negative regulation of calcium ion transmembrane transporter activity negative regulation of peptidyl-serine dephosphorylation uc007ket.1 uc007ket.2 uc007ket.3 uc007ket.4 
ENSMUST00000067673.13 Ms4a5 ENSMUST00000067673.13 membrane-spanning 4-domains, subfamily A, member 5, transcript variant 1 (from RefSeq NM_183190.3) ENSMUST00000067673.1 ENSMUST00000067673.10 ENSMUST00000067673.11 ENSMUST00000067673.12 ENSMUST00000067673.2 ENSMUST00000067673.3 ENSMUST00000067673.4 ENSMUST00000067673.5 ENSMUST00000067673.6 ENSMUST00000067673.7 ENSMUST00000067673.8 ENSMUST00000067673.9 Ms4a5 NM_183190 Q810P8 Q810P8_MOUSE uc008gry.1 uc008gry.2 uc008gry.3 Belongs to the MS4A family. molecular_function cellular_component biological_process membrane integral component of membrane uc008gry.1 uc008gry.2 uc008gry.3 
ENSMUST00000067680.11 Adam12 ENSMUST00000067680.11 ADAM metallopeptidase domain 12 (from RefSeq NM_007400.3) ADA12_MOUSE ENSMUST00000067680.1 ENSMUST00000067680.10 ENSMUST00000067680.2 ENSMUST00000067680.3 ENSMUST00000067680.4 ENSMUST00000067680.5 ENSMUST00000067680.6 ENSMUST00000067680.7 ENSMUST00000067680.8 ENSMUST00000067680.9 F8VQN4 Mltna NM_007400 Q61824 uc009kdp.1 uc009kdp.2 uc009kdp.3 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein that localizes to the cell surface. About a third of the mice lacking the encoded protein die before weaning. Overexpression of the encoded protein in a mouse model of Duchenne muscular dystrophy alleviates the muscle pathology by preventing cell necrosis and inflammation. [provided by RefSeq, May 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D50411.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Interacts with alpha-actinin-2 and with syndecans. Interacts with SH3PXD2A. Interacts with FST3. Interacts with RACK1; the interaction is required for PKC-dependent translocation of ADAM12 to the cell membrane (By similarity). Q61824; P35609: ACTN2; Xeno; NbExp=3; IntAct=EBI-77785, EBI-77797; Membrane; Single-pass type I membrane protein. Expressed during early developing mesenchymal cells that give rise to skeletal muscle, bones and visceral organs. Not expressed in adult normal muscle but expressed in regenerating muscle. At the onset of myoblast fusion. The first 30 amino acids of the cytoplasmic domain contain a major binding site to alpha-actinin-2. This interaction is necessary to promote muscle cell fusion. The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin- dependent cell spreading. In carcinoma cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading (By similarity). The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Marker of skeletal muscle regeneration. metalloendopeptidase activity protein binding extracellular space nucleoplasm plasma membrane proteolysis cell adhesion peptidase activity metallopeptidase activity membrane integral component of membrane hydrolase activity SH3 domain binding positive regulation of angiogenesis metal ion binding uc009kdp.1 uc009kdp.2 uc009kdp.3 
ENSMUST00000067689.9 Tnrc6b ENSMUST00000067689.9 trinucleotide repeat containing 6b, transcript variant 2 (from RefSeq NM_177124.4) ENSMUST00000067689.1 ENSMUST00000067689.2 ENSMUST00000067689.3 ENSMUST00000067689.4 ENSMUST00000067689.5 ENSMUST00000067689.6 ENSMUST00000067689.7 ENSMUST00000067689.8 Kiaa1093 NM_177124 Q80TK4 Q8BKI2 TNR6B_MOUSE uc007wvt.1 uc007wvt.2 uc007wvt.3 Plays a role in RNA-mediated gene silencing by both micro- RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA- dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Interacts with AGO1, AGO2, AGO3 and AGO4. Interacts with CNOT1; the interaction mediates the association with the CCR4-NOT complex. Interacts with PAN3; the interaction mediates the association with the PAN complex. Interacts with MOV10; the interaction is direct and RNA-dependent. Cytoplasm, P-body Note=Mammalian P-bodies are also known as GW bodies (GWBs). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BKI2-1; Sequence=Displayed; Name=2; IsoId=Q8BKI2-2; Sequence=VSP_037294, VSP_037295, VSP_037296, VSP_037297; Belongs to the GW182 family. P-body nucleic acid binding RNA binding nucleoplasm cytoplasm regulation of translation gene silencing by RNA gene silencing by miRNA miRNA mediated inhibition of translation positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay uc007wvt.1 uc007wvt.2 uc007wvt.3 
ENSMUST00000067692.13 Rad51c ENSMUST00000067692.13 RAD51 paralog C, transcript variant 2 (from RefSeq NM_053269.4) B2KGK7 ENSMUST00000067692.1 ENSMUST00000067692.10 ENSMUST00000067692.11 ENSMUST00000067692.12 ENSMUST00000067692.2 ENSMUST00000067692.3 ENSMUST00000067692.4 ENSMUST00000067692.5 ENSMUST00000067692.6 ENSMUST00000067692.7 ENSMUST00000067692.8 ENSMUST00000067692.9 NM_053269 Q5SX32 Q8C653 Q924H5 RA51C_MOUSE Rad51l2 uc007ktp.1 uc007ktp.2 uc007ktp.3 uc007ktp.4 Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD51 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1- BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single- stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA- dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross- link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. Part of the RAD51 paralog protein complexes BCDX2 and CX3; the complexes have a ring-like structure arranged into a flat disc around a central channel (By similarity). The BCDX2 complex consits of RAD51B, RAD51C, RAD51D and XRCC2; the CX3 complex consists of RAD51C and XRCC3 (By similarity). The BCDX2 subcomplex RAD51B:RAD51C interacts with RAD51 (By similarity). Interacts with SWSAP1; involved in homologous recombination repair (By similarity). Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3 (By similarity). Interacts with HELQ (PubMed:24005329). Nucleus Cytoplasm Cytoplasm, perinuclear region Mitochondrion Note=DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q924H5-1; Sequence=Displayed; Name=2; IsoId=Q924H5-2; Sequence=VSP_040206; Expressed in the heart, brain, spleen, lung, liver, kidney and testis but not detected in skeletal muscle. Expressed in embryos at various developmental stages. The expression is found to be higher between 11 and 15 days of gestation compared to day 7 or 17. Belongs to the RecA family. RAD51 subfamily. nucleotide binding four-way junction DNA binding telomere maintenance via recombination double-strand break repair via homologous recombination DNA binding protein binding ATP binding nucleus replication fork cytoplasm mitochondrion cytosol DNA repair DNA recombination cellular response to DNA damage stimulus female meiosis sister chromatid cohesion reciprocal meiotic recombination male meiosis I spermatogenesis DNA-dependent ATPase activity crossover junction endodeoxyribonuclease activity positive regulation of G2/M transition of mitotic cell cycle cell junction Rad51B-Rad51C-Rad51D-XRCC2 complex Rad51C-XRCC3 complex intracellular membrane-bounded organelle perinuclear region of cytoplasm Holliday junction resolvase complex uc007ktp.1 uc007ktp.2 uc007ktp.3 uc007ktp.4 
ENSMUST00000067695.8 Usp17la ENSMUST00000067695.8 ubiquitin specific peptidase 17-like A (from RefSeq NM_007887.2) Dub-1 Dub1 ENSMUST00000067695.1 ENSMUST00000067695.2 ENSMUST00000067695.3 ENSMUST00000067695.4 ENSMUST00000067695.5 ENSMUST00000067695.6 ENSMUST00000067695.7 NM_007887 Q61068 U17PA_MOUSE uc009iwz.1 uc009iwz.2 uc009iwz.3 uc009iwz.4 Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Has deubiquitinating enzyme activity for DNAH5, suggesting a role in the regulation of DNAH5 degradation by the ubiquitin-proteasome pathway. Has growth-suppressing activity; induces arrest in G1 phase upon controlled expression. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Expressed in hematopoietic progenitor cell lines Ba/F3 and FDCP1. Not detected in brain, lung, liver, kidney, thymus, spleen and bone marrow. Up-regulated by IL3, IL5 and CSF2. Polyubiquitinated; ubiquitination leads to its subsequent degradation. Belongs to the peptidase C19 family. cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity regulation of apoptotic process uc009iwz.1 uc009iwz.2 uc009iwz.3 uc009iwz.4 
ENSMUST00000067715.5 Pabpc1l ENSMUST00000067715.5 poly(A) binding protein, cytoplasmic 1-like (from RefSeq NM_001114079.2) A2A5N3 A2A5N3_MOUSE ENSMUST00000067715.1 ENSMUST00000067715.2 ENSMUST00000067715.3 ENSMUST00000067715.4 Epab NM_001114079 Pabpc1l uc012cix.1 uc012cix.2 uc012cix.3 uc012cix.4 Binds the poly(A) tail of mRNA. Cytoplasm Nucleus Belongs to the polyadenylate-binding protein type-1 family. oocyte maturation nucleic acid binding RNA binding mRNA 3'-UTR binding nucleus cytoplasm cytosol chromatin remodeling mRNA polyadenylation poly(A) binding poly(U) RNA binding cytoplasmic stress granule chromatin-mediated maintenance of transcription nucleus localization ribonucleoprotein complex uc012cix.1 uc012cix.2 uc012cix.3 uc012cix.4 
ENSMUST00000067744.8 Cggbp1 ENSMUST00000067744.8 CGG triplet repeat binding protein 1, transcript variant 1 (from RefSeq NM_178647.3) CGBP1_MOUSE ENSMUST00000067744.1 ENSMUST00000067744.2 ENSMUST00000067744.3 ENSMUST00000067744.4 ENSMUST00000067744.5 ENSMUST00000067744.6 ENSMUST00000067744.7 NM_178647 Q8BHG9 Q8K2K1 uc007zqf.1 uc007zqf.2 uc007zqf.3 Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter (By similarity). Nucleus Binding is severely inhibited by complete or partial cytosine-specific DNA methylation of the binding motif. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter identical protein binding uc007zqf.1 uc007zqf.2 uc007zqf.3 
ENSMUST00000067752.5 Tmt1a ENSMUST00000067752.5 thiol methyltransferase 1A1 (from RefSeq NM_027334.3) ENSMUST00000067752.1 ENSMUST00000067752.2 ENSMUST00000067752.3 ENSMUST00000067752.4 Mettl7a Mettl7a1 NM_027334 Q8C6B0 Q8C6B0_MOUSE Tmt1a uc007xqv.1 uc007xqv.2 uc007xqv.3 lipid particle methyltransferase activity membrane integral component of membrane transferase activity methylation uc007xqv.1 uc007xqv.2 uc007xqv.3 
ENSMUST00000067780.10 Myef2 ENSMUST00000067780.10 myelin basic protein expression factor 2, repressor, transcript variant 2 (from RefSeq NM_010852.3) ENSMUST00000067780.1 ENSMUST00000067780.2 ENSMUST00000067780.3 ENSMUST00000067780.4 ENSMUST00000067780.5 ENSMUST00000067780.6 ENSMUST00000067780.7 ENSMUST00000067780.8 ENSMUST00000067780.9 Kiaa1341 MYEF2_MOUSE Mef2 NM_010852 Q60690 Q6P930 Q6ZPT3 Q8C854 Q8QZZ1 uc008mby.1 uc008mby.2 uc008mby.3 Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA. Monomer. Nucleus. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8C854-4; Sequence=Displayed; Name=2; IsoId=Q8C854-3; Sequence=VSP_013455; Name=3; IsoId=Q8C854-1; Sequence=VSP_013457, VSP_013458, VSP_013459; Name=4; IsoId=Q8C854-2; Sequence=VSP_013456, VSP_013460, VSP_013461; Highly expressed in the brain. Sequence=AAH60946.1; Type=Erroneous initiation; Evidence=; Sequence=BAC98146.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding single-stranded DNA binding RNA binding mRNA binding nucleus cytoplasm post-mRNA release spliceosomal complex ribonucleoprotein complex regulation of mRNA stability involved in response to oxidative stress uc008mby.1 uc008mby.2 uc008mby.3 
ENSMUST00000067784.8 Cdh24 ENSMUST00000067784.8 cadherin-like 24 (from RefSeq NM_199470.3) CAD24_MOUSE ENSMUST00000067784.1 ENSMUST00000067784.2 ENSMUST00000067784.3 ENSMUST00000067784.4 ENSMUST00000067784.5 ENSMUST00000067784.6 ENSMUST00000067784.7 NM_199470 Q6PFX6 uc011zlc.1 uc011zlc.2 uc011zlc.3 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion (By similarity). Associates with alpha-, beta- and delta-catenins. Cell membrane ; Single-pass type I membrane protein Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. cell morphogenesis calcium ion binding plasma membrane cell-cell junction cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules beta-catenin binding cytoskeletal protein binding cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex adherens junction organization protein homodimerization activity cell-cell adhesion mediated by cadherin alpha-catenin binding cadherin binding metal ion binding delta-catenin binding cell-cell adhesion uc011zlc.1 uc011zlc.2 uc011zlc.3 
ENSMUST00000067786.9 Slc20a2 ENSMUST00000067786.9 solute carrier family 20, member 2, transcript variant 1 (from RefSeq NM_011394.4) E9QLQ8 ENSMUST00000067786.1 ENSMUST00000067786.2 ENSMUST00000067786.3 ENSMUST00000067786.4 ENSMUST00000067786.5 ENSMUST00000067786.6 ENSMUST00000067786.7 ENSMUST00000067786.8 NM_011394 Pit2 Q3TBZ8 Q80UP8 Q9ES96 S20A2_MOUSE uc009ldf.1 uc009ldf.2 uc009ldf.3 uc009ldf.4 Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11003594, PubMed:23968976, PubMed:26822507, PubMed:30721528). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (PubMed:30721528). Required to maintain normal cerebrospinal fluid phosphate levels (PubMed:26822507). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (PubMed:23968976). Reaction=2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in); Xref=Rhea:RHEA:71259, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; Evidence= Homodimer. Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Brain. In the brain, expressed in the choroid plexus, ependyma and arteriolar smooth muscle cells (at protein level) (PubMed:26822507). Widely expressed including intestine, kidney, heart, liver, testis and skin. Expressed throughout the vertcal crypt-axial axis of intestinal epithelium (PubMed:11003594). Mice develop basal ganglia calcification and display significantly elevated phosphate in cerebral spinal fluid, calcified optic nerve tissue, moderate to severe hydrocephalus, poor skeletal development, low body weight and significantly decreased postweaning survival rates (PubMed:26822507). Juvenile mice exhibit abnormal endochondral and intramembranous ossification, decreased mineral accrual, and short stature (PubMed:30721528). Adults exhibit only small reductions in bone mass and mineralization but a profound impairment of bone strength (PubMed:30721528). Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. inorganic phosphate transmembrane transporter activity plasma membrane integral component of plasma membrane ion transport sodium ion transport phosphate ion transport symporter activity sodium:inorganic phosphate symporter activity membrane integral component of membrane viral process phosphate ion transmembrane transport sodium ion transmembrane transport uc009ldf.1 uc009ldf.2 uc009ldf.3 uc009ldf.4 
ENSMUST00000067790.7 Ugt2b5 ENSMUST00000067790.7 UDP glucuronosyltransferase 2 family, polypeptide B5 (from RefSeq NM_009467.3) ENSMUST00000067790.1 ENSMUST00000067790.2 ENSMUST00000067790.3 ENSMUST00000067790.4 ENSMUST00000067790.5 ENSMUST00000067790.6 NM_009467 Q8K169 Q8K169_MOUSE Ugt2b5 uc008xyf.1 uc008xyf.2 uc008xyf.3 uc008xyf.4 uc008xyf.5 Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; Membrane ; Single- pass membrane protein Belongs to the UDP-glycosyltransferase family. glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups uc008xyf.1 uc008xyf.2 uc008xyf.3 uc008xyf.4 uc008xyf.5 
ENSMUST00000067795.13 Lcor ENSMUST00000067795.13 Repressor of ligand-dependent transcription activation by various nuclear repressors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (By similarity). May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. (from UniProt Q6ZPI3) AK155007 ENSMUST00000067795.1 ENSMUST00000067795.10 ENSMUST00000067795.11 ENSMUST00000067795.12 ENSMUST00000067795.2 ENSMUST00000067795.3 ENSMUST00000067795.4 ENSMUST00000067795.5 ENSMUST00000067795.6 ENSMUST00000067795.7 ENSMUST00000067795.8 ENSMUST00000067795.9 Kiaa1795 LCOR_MOUSE Mlr2 Q3U302 Q5CZW7 Q6ZPI3 Q80VA8 Q8BGT2 Q8C9Q0 uc008hly.1 uc008hly.2 uc008hly.3 uc008hly.4 Repressor of ligand-dependent transcription activation by various nuclear repressors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (By similarity). May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2 (By similarity). Nucleus Detected in heart and kidney. Sequence=BAC98252.1; Type=Erroneous initiation; Evidence=; Sequence=BAE32988.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter DNA binding chromatin binding protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter uc008hly.1 uc008hly.2 uc008hly.3 uc008hly.4 
ENSMUST00000067821.13 Ercc6l2 ENSMUST00000067821.13 excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2, transcript variant 2 (from RefSeq NM_023507.5) E9Q4J6 ENSMUST00000067821.1 ENSMUST00000067821.10 ENSMUST00000067821.11 ENSMUST00000067821.12 ENSMUST00000067821.2 ENSMUST00000067821.3 ENSMUST00000067821.4 ENSMUST00000067821.5 ENSMUST00000067821.6 ENSMUST00000067821.7 ENSMUST00000067821.8 ENSMUST00000067821.9 ER6L2_MOUSE Ercc6l2 NM_023507 Q6DI94 Q8BIV4 Q8BM40 Q8K267 Q8R2Z6 Q9DA70 Q9DD01 Q9JIM3 Rad26l uc007qyc.1 uc007qyc.2 uc007qyc.3 uc007qyc.4 May be involved in early DNA damage response. Interacts with NEK6. Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Mitochondrion Note=Colocalizes with NEK6 in the centrosome. In response to DNA damage, translocates from the cytosol to mitochondria and nucleus in a reactive oxygen species (ROS)-dependent manner. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9JIM3-1; Sequence=Displayed; Name=2; IsoId=Q9JIM3-2; Sequence=VSP_054675, VSP_054676; Name=3; IsoId=Q9JIM3-3; Sequence=VSP_054670, VSP_054671, VSP_054674; Name=4; IsoId=Q9JIM3-4; Sequence=VSP_054672, VSP_054673; Phosphorylated by NEK6. Belongs to the SNF2/RAD54 helicase family. Sequence=AAH26917.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH32964.1; Type=Frameshift; Evidence=; Sequence=AAH75679.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB24414.1; Type=Miscellaneous discrepancy; Note=The first 10 codons may be found on an alternative exon not observed on any other cDNA/EST.; Evidence=; nucleotide binding DNA binding helicase activity ATP binding nucleus cytoplasm mitochondrion microtubule organizing center cytoskeleton DNA repair cellular response to DNA damage stimulus hydrolase activity protein kinase binding macromolecular complex cellular response to reactive oxygen species interstrand cross-link repair centrosome uc007qyc.1 uc007qyc.2 uc007qyc.3 uc007qyc.4 
ENSMUST00000067836.9 Ano9 ENSMUST00000067836.9 anoctamin 9 (from RefSeq NM_178381.3) ANO9_MOUSE Ano9 ENSMUST00000067836.1 ENSMUST00000067836.2 ENSMUST00000067836.3 ENSMUST00000067836.4 ENSMUST00000067836.5 ENSMUST00000067836.6 ENSMUST00000067836.7 ENSMUST00000067836.8 NM_178381 P86044 Tmem16j uc012fwo.1 uc012fwo.2 uc012fwo.3 Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium- activated chloride channel (CaCC) activity (By similarity). Can inhibit the activity of ANO1 (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38664; Evidence=; Reaction=a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in); Xref=Rhea:RHEA:38899, ChEBI:CHEBI:18390; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38900; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38573; Evidence=; Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane. Predominant expression seen in epithelial tissues. In the developing respiratory system, expression is restricted to the lung epithelium at 14.5 dpc. At 14.5 dpc and 16.5 dpc, expressed in the epithelium of the esophagus, small intestine, stomach and pancreas. At 16.5 dpc, detected in bronchial epithelium. In the developing skeleton, expressed in the perichondria of developing ribs at 14.5 dpc. In developing skin, expression is detected in the most suprabasal layers at 16.5 dpc. The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. Belongs to the anoctamin family. intracellular calcium activated chloride channel activity plasma membrane chloride transport lipid transport membrane integral component of membrane phospholipid scramblase activity ion transmembrane transport calcium activated phospholipid scrambling calcium activated phosphatidylserine scrambling calcium activated phosphatidylcholine scrambling calcium activated galactosylceramide scrambling negative regulation of intracellular calcium activated chloride channel activity uc012fwo.1 uc012fwo.2 uc012fwo.3 
ENSMUST00000067841.8 Irs4 ENSMUST00000067841.8 insulin receptor substrate 4 (from RefSeq NM_010572.2) A2BHF6 ENSMUST00000067841.1 ENSMUST00000067841.2 ENSMUST00000067841.3 ENSMUST00000067841.4 ENSMUST00000067841.5 ENSMUST00000067841.6 ENSMUST00000067841.7 IRS4_MOUSE NM_010572 Q8BRB9 Q9Z0Y7 uc009ulp.1 uc009ulp.2 uc009ulp.3 Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin- stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH (By similarity). Interacts with SOCS6 in response to stimulation with either insulin or IGF1. Interacts with PIK3R1 and GRB2. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Expressed in skeletal muscle, brain, heart, kidney and liver. First detected from days 15 and 17 embryos. Phosphorylated on tyrosine residues in response to both insulin and IGF1 signaling. Phosphorylated on Tyr-894 in response to FGF2 signaling. Phosphorylation of Tyr-894 is required for GRB2, phospholipase C-gamma and phosphatidylinositol 3-kinase interaction (By similarity). Slight defects in growth, reproduction and glucose homeostasis. Sequence=BAC32246.1; Type=Erroneous initiation; Evidence=; insulin receptor binding protein binding cytosol plasma membrane signal transduction insulin receptor signaling pathway membrane protein domain specific binding macromolecular complex phosphatidylinositol 3-kinase binding uc009ulp.1 uc009ulp.2 uc009ulp.3 
ENSMUST00000067843.10 Hmbox1 ENSMUST00000067843.10 homeobox containing 1, transcript variant 2 (from RefSeq NM_177338.7) ENSMUST00000067843.1 ENSMUST00000067843.2 ENSMUST00000067843.3 ENSMUST00000067843.4 ENSMUST00000067843.5 ENSMUST00000067843.6 ENSMUST00000067843.7 ENSMUST00000067843.8 ENSMUST00000067843.9 HMBX1_MOUSE NM_177338 Q80WC2 Q8BJA3 Q8BWE7 Q99LV1 uc007uir.1 uc007uir.2 Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (By similarity). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (By similarity). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (PubMed:23685356). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (By similarity). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (By similarity). Might also be involved in the DNA damage response at telomeres (By similarity). Associates with the telomerase holoenzyme complex. Interacts with DKC1, XRCC6 and COIL. Nucleus Cytoplasm Chromosome, telomere Nucleus, Cajal body Nucleus, PML body Note=Predominantly detected in cytoplasm. Localizes in a dynamic manner to actively processed telomeres. Localizes to the periphery of Cajal bodies. Associates with PML nuclear bodies in telomerase-negative cells. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BJA3-1; Sequence=Displayed; Name=2; IsoId=Q8BJA3-2; Sequence=VSP_018114, VSP_018115; Name=3; IsoId=Q8BJA3-3; Sequence=VSP_018116; Name=4; IsoId=Q8BJA3-4; Sequence=VSP_018115; The homeobox domain is required for binding to 5'-TTAGGG-3' repeats in telomeres, and for telomere localization. Reported to have transcriptional repression activity in vitro. However, it is unclear whether this protein has any function in transcription in vivo. negative regulation of transcription from RNA polymerase II promoter chromosome, telomeric region nuclear chromosome, telomeric region DNA binding double-stranded telomeric DNA binding protein binding nucleus nucleoplasm chromosome cytoplasm cytosol Cajal body nuclear body PML body positive regulation of telomere maintenance via telomerase positive regulation of chromatin binding telomeric DNA binding identical protein binding sequence-specific DNA binding macromolecular complex binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of telomerase activity positive regulation of telomerase activity uc007uir.1 uc007uir.2 
ENSMUST00000067853.6 Tmem119 ENSMUST00000067853.6 transmembrane protein 119, transcript variant 1 (from RefSeq NM_146162.3) ENSMUST00000067853.1 ENSMUST00000067853.2 ENSMUST00000067853.3 ENSMUST00000067853.4 ENSMUST00000067853.5 NM_146162 Q8BP14 Q8R138 TM119_MOUSE uc008yyq.1 uc008yyq.2 uc008yyq.3 uc008yyq.4 Plays an important role in bone formation and normal bone mineralization (PubMed:26207632, PubMed:22416756, PubMed:20025746). Promotes the differentiation of myoblasts into osteoblasts (PubMed:22416756, PubMed:20025746, PubMed:22579779). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway (PubMed:21239498, PubMed:22579779). Up-regulates the expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451). Essential for normal spermatogenesis and late testicular differentiation (PubMed:26207632). Interacts with SMAD1, SMAD5 and RUNX2. Cell membrane ; Single-pass type I membrane protein Cytoplasm Endoplasmic reticulum membrane Secreted Expressed in spermatocytes and spermatids in the developing testis (at protein level). Expressed in the brain, heart, lung, spleen, skeletal muscle, ovary, testis and epididymis (PubMed:26207632). Predominantly expressed in osteoblasts (PubMed:20025746). Highly expressed in early and late stage osteoblasts of developing embryos (at protein level). By parathyroid hormone (PTH) in osteoblasts (at protein level). Mice show a significant decrease in bone formation and bone mineralization and the mineralization defect is independent of calcium and phosphate metabolisms. Testis is smaller, sperm number is significantly decreased and testicular differentiation is perturbed (PubMed:26207632). Significantly reduced cortical thickness in the mid-shaft of the femur at postnatal day 14 (P14), and progressive bone hypoplasia after 8 weeks (PubMed:22416756). ossification osteoblast differentiation positive regulation of protein phosphorylation endochondral ossification protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane spermatogenesis positive regulation of gene expression negative regulation of myotube differentiation membrane integral component of membrane cell differentiation positive regulation of bone mineralization biomineral tissue development positive regulation of osteoblast proliferation positive regulation of osteoblast differentiation negative regulation of bone resorption spermatid differentiation positive regulation of bone development uc008yyq.1 uc008yyq.2 uc008yyq.3 uc008yyq.4 
ENSMUST00000067857.11 Aifm2 ENSMUST00000067857.11 apoptosis-inducing factor, mitochondrion-associated 2, transcript variant 2 (from RefSeq NM_178058.4) Aifm2 Amid ENSMUST00000067857.1 ENSMUST00000067857.10 ENSMUST00000067857.2 ENSMUST00000067857.3 ENSMUST00000067857.4 ENSMUST00000067857.5 ENSMUST00000067857.6 ENSMUST00000067857.7 ENSMUST00000067857.8 ENSMUST00000067857.9 FSP1_MOUSE NM_178058 Q8BUE4 Q8CHZ2 uc007fgk.1 uc007fgk.2 uc007fgk.3 uc007fgk.4 A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis (By similarity). At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis (By similarity). Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis (By similarity). This anti-ferroptotic function is independent of cellular glutathione levels (By similarity). Also acts as a potent radical- trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms (PubMed:35922516). Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis (PubMed:26689472). May play a role in mitochondrial stress signaling (PubMed:26689472). Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death (PubMed:26689472). Reaction=H(+) + NADH + ubiquinone-10 = NAD(+) + ubiquinol-10; Xref=Rhea:RHEA:61984, ChEBI:CHEBI:15378, ChEBI:CHEBI:46245, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:64183; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61985; Evidence=; Reaction=H(+) + NADH + phylloquinone = NAD(+) + phylloquinol; Xref=Rhea:RHEA:74075, ChEBI:CHEBI:15378, ChEBI:CHEBI:18067, ChEBI:CHEBI:28433, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74076; Evidence=; Reaction=H(+) + menaquinone-4 + NADH = menaquinol-4 + NAD(+); Xref=Rhea:RHEA:74079, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78277, ChEBI:CHEBI:193091; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74080; Evidence=; Reaction=H(+) + menadione + NADH = menadiol + NAD(+); Xref=Rhea:RHEA:69695, ChEBI:CHEBI:6746, ChEBI:CHEBI:15378, ChEBI:CHEBI:28869, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69696; Evidence=; Name=6-hydroxy-FAD; Xref=ChEBI:CHEBI:60470; Evidence=; Note=Binds 6-hydroxy-FAD non-covalently. ; The modification by 4-hydroxy-2-nonenal (HNE) adduction in mitochondria results in loss of the oxidoreductase activity and activation of a novel function in mitochondrial oxidative stress signaling. Interacts with importin subunits KPNA2 and IPO5; this interaction likely mediates the translocation into the nucleus upon oxidative stress. Lipid droplet Cell membrane ; Lipid-anchor Cytoplasm Mitochondrion membrane Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8BUE4-1; Sequence=Displayed; Name=2 ; IsoId=Q8BUE4-2; Sequence=VSP_052049; Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in liver, testis, and kidney, and expressed at lower levels in pancreas, spleen, brain and lung (PubMed:16186796). Expressed in heart (at protein level) (PubMed:26689472). Expression is up-regulated in mouse embryonic fibroblasts by genotoxic reagents 5-fluorouracil and etoposide (PubMed:16186796). Up- regulated in cardiac cells by anticancer drug doxorubicin (PubMed:26689472). N-myristoylation at Gly-2 mediates the recruitment to lipid droplets and plasma membrane. Belongs to the FAD-dependent oxidoreductase family. [Isoform 2]: Sequence=AAH38129.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; DNA binding electron-transferring-flavoprotein dehydrogenase activity cytoplasm mitochondrion mitochondrial outer membrane lipid particle cytosol apoptotic mitochondrial changes membrane integral component of membrane oxidoreductase activity respiratory electron transport chain positive regulation of apoptotic process flavin adenine dinucleotide binding oxidation-reduction process uc007fgk.1 uc007fgk.2 uc007fgk.3 uc007fgk.4 
ENSMUST00000067864.8 Srsf12 ENSMUST00000067864.8 serine and arginine-rich splicing factor 12, transcript variant 2 (from RefSeq NM_177774.5) ENSMUST00000067864.1 ENSMUST00000067864.2 ENSMUST00000067864.3 ENSMUST00000067864.4 ENSMUST00000067864.5 ENSMUST00000067864.6 ENSMUST00000067864.7 NM_177774 Q8C8K3 SRS12_MOUSE Sfrs13b Srrp Srsf13b uc008sft.1 uc008sft.2 Splicing factor that seems to antagonize SR proteins in pre- mRNA splicing regulation. Nucleus Belongs to the splicing factor SR family. In contrast to the human ortholog, lacks the RRM (RNA recognition motif) domain at the N-terminus. regulation of alternative mRNA splicing, via spliceosome mRNA 5'-splice site recognition nucleus mRNA processing RNA splicing uc008sft.1 uc008sft.2 
ENSMUST00000067880.13 Adam10 ENSMUST00000067880.13 a disintegrin and metallopeptidase domain 10 (from RefSeq NM_007399.4) ADA10_MOUSE B8JJJ0 ENSMUST00000067880.1 ENSMUST00000067880.10 ENSMUST00000067880.11 ENSMUST00000067880.12 ENSMUST00000067880.2 ENSMUST00000067880.3 ENSMUST00000067880.4 ENSMUST00000067880.5 ENSMUST00000067880.6 ENSMUST00000067880.7 ENSMUST00000067880.8 ENSMUST00000067880.9 Kuz Madm NM_007399 O35598 uc009qor.1 uc009qor.2 uc009qor.3 uc009qor.4 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero with multiple defects of the developing central nervous system, somites, and cardiovascular system. [provided by RefSeq, May 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC057346.1, SRR1660813.163299.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis (PubMed:17245433, PubMed:29325091, PubMed:29430990, PubMed:30639848). Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity (PubMed:9244301, PubMed:30463011, PubMed:26668317). Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) at '687-Lys-|-Leu-688' (By similarity). Contributes to the normal cleavage of the cellular prion protein (By similarity). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (By similarity). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (PubMed:9244301). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (By similarity). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (PubMed:17245433). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177). Enhances the cleavage of CHL1 by BACE1 (PubMed:29325091). Cleaves NRCAM (PubMed:29430990). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity). Involved in the development and maturation of glomerular and coronary vasculature (PubMed:30446855, PubMed:29397483). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (PubMed:30639848). May regulate the EFNA5-EPHA3 signaling (By similarity). Reaction=Endopeptidase of broad specificity.; EC=3.4.24.81; Evidence= Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Catalytically inactive when the propeptide is intact and associated with the mature enzyme (By similarity). The disintegrin and cysteine-rich regions modulate access of substrates to exerts an inhibitory effect on the cleavage of ADAM10 substrates (By similarity). Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function, the cleavage occurs in trans, with ADAM10 and its substrate being on the membranes of opposing cells (By similarity). Interacts with the clathrin adapter AP2 complex subunits AP2A1, AP2A2, AP2B1, and AP2M1; this interaction facilitates ADAM10 endocytosis from the plasma membrane during long-term potentiation in hippocampal neurons (PubMed:23676497). Forms a ternary complex composed of ADAM10, EPHA4 and CADH1; within the complex, ADAM10 cleaves CADH1 which disrupts adherens junctions (PubMed:30639848). Interacts with EPHA2 (PubMed:10958785). Interacts with NGF in a divalent cation-dependent manner (By similarity). Interacts with TSPAN14; the interaction promotes ADAM10 maturation and cell surface expression (PubMed:23035126, PubMed:26668317). Interacts with TSPAN5, TSPAN10, TSPAN14, TSPAN15, TSPAN17 and TSPAN33; these interactions regulate ADAM10 substrate specificity, endocytosis and turnover (PubMed:23035126, PubMed:26668317). Interacts (via extracellular domain) with TSPAN33 (via extracellular domain) and (via cytoplasmic domain) with AFDN; interaction with TSPAN33 allows the docking of ADAM10 to zonula adherens through a PDZ11-dependent interaction between TSPAN33 and PLEKHA7 while interaction with AFDN locks ADAM10 at zonula adherens (PubMed:30463011). Interacts with DLG1; this interaction recruits ADAM10 to the cell membrane during long-term depression in hippocampal neurons (PubMed:23676497). Interacts (via extracellular domain) with BACE1 (via extracellular domain) (PubMed:29325091). Interacts with FAM171A1 (By similarity). Cell membrane ingle-pass type I membrane protein Golgi apparatus membrane ; Single-pass type I membrane protein Cytoplasmic vesicle, clathrin-coated vesicle Cell projection, axon Cell projection, dendrite Cell junction, adherens junction Cytoplasm Note=Is localized in the plasma membrane but is also expressed in the Golgi apparatus and in clathrin-coated vesicles derived likely from the Golgi (By similarity). During long term depression, it is recruited to the cell membrane by DLG1 (PubMed:23676497). The immature form is mainly located near cytoplasmic fibrillar structures, while the mature form is predominantly located at zonula adherens and the cell membrane (PubMed:30463011). The localization and clustering of mature ADAM10 to zonula adherens is regulated by AFDN, TSPAN33, PLEKHA7 and PDZD11 (PubMed:30463011). Expressed in the brain, specifically in neurons and astrocytes (at protein level) (PubMed:23676497, PubMed:29325091). Expressed in inner and outer pillar cells of the organ of Corti (at protein level) (PubMed:30639848). Expressed in kidney and lung (PubMed:30463011). Widely expressed in the nervous system at 18 dpc, with high expression in the posterior midbrain, which diminished toward the anterior midbrain. The Cys-rich region C-terminal to the disintegrin domain functions as a substrate-recognition module, it recognizes the EFNA5- EPHA3 Complex but not the individual proteins (By similarity). Both Cys-rich and stalk region are necessary for interaction with TSPAN5, TSPAN10, TSPAN14, TSPAN17, TSPAN33 (PubMed:26668317). Stalk region is sufficient for interaction with TSPAN15 (PubMed:26668317). The propeptide keeps the metalloprotease in a latent form via a cysteine switch mechanism. This mechanism may be mediated by a highly conserved cysteine (Cys-173) in the propeptide, which interacts and neutralizes the zinc-coordinating HEXGHXXGXXHD catalytic core of the metalloprotease domain. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. The precursor is cleaved by furin and PCSK7. Conditional knockout in endothelial cells results in abnormal myocardial compaction, insufficient systolic contraction, and enlarged hearts relative to body weight (PubMed:30446855). Conditional knockout in endothelial cells also results in dilated glomerular vessels and maturation defects in glomerular endothelial cells but kidney function is not impacted (PubMed:29397483). Golgi membrane in utero embryonic development endopeptidase activity metalloendopeptidase activity protein binding extracellular space nucleus cytoplasm Golgi apparatus Golgi-associated vesicle trans-Golgi network plasma membrane adherens junction protein phosphorylation proteolysis membrane protein ectodomain proteolysis nucleocytoplasmic transport negative regulation of cell adhesion Notch signaling pathway Notch receptor processing spermatogenesis synaptic vesicle peptidase activity metallopeptidase activity positive regulation of cell proliferation regulation of Notch signaling pathway cell surface positive regulation of T cell chemotaxis postsynaptic density membrane integral component of membrane protein processing hydrolase activity SH3 domain binding protein kinase binding cell junction clathrin-coated vesicle positive regulation of cell growth positive regulation of cell migration axon dendrite cytoplasmic vesicle beta-amyloid formation response to tumor necrosis factor monocyte activation SH2 domain binding protein homodimerization activity amyloid precursor protein catabolic process cell projection neuronal cell body positive regulation of apoptotic process dendritic spine postsynaptic membrane metal ion binding pore complex pore complex assembly PMA-inducible membrane protein ectodomain proteolysis constitutive protein ectodomain proteolysis regulation of dendritic spine morphogenesis cochlea development perinuclear endoplasmic reticulum synaptic membrane tetraspanin-enriched microdomain response to antineoplastic agent postsynapse glutamatergic synapse regulation of vasculature development toxin transport metalloendopeptidase activity involved in amyloid precursor protein catabolic process uc009qor.1 uc009qor.2 uc009qor.3 uc009qor.4 
ENSMUST00000067888.14 Tpk1 ENSMUST00000067888.14 thiamine pyrophosphokinase, transcript variant 1 (from RefSeq NM_013861.4) ENSMUST00000067888.1 ENSMUST00000067888.10 ENSMUST00000067888.11 ENSMUST00000067888.12 ENSMUST00000067888.13 ENSMUST00000067888.2 ENSMUST00000067888.3 ENSMUST00000067888.4 ENSMUST00000067888.5 ENSMUST00000067888.6 ENSMUST00000067888.7 ENSMUST00000067888.8 ENSMUST00000067888.9 NM_013861 Q3UWB5 Q8CAB5 Q8CEE8 Q8R1Q6 Q9R0M5 TPK1_MOUSE Tpk1 uc009bsq.1 uc009bsq.2 uc009bsq.3 Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. Reaction=ATP + thiamine = AMP + H(+) + thiamine diphosphate; Xref=Rhea:RHEA:11576, ChEBI:CHEBI:15378, ChEBI:CHEBI:18385, ChEBI:CHEBI:30616, ChEBI:CHEBI:58937, ChEBI:CHEBI:456215; EC=2.7.6.2; Evidence=; Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1. Homodimer. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9R0M5-1; Sequence=Displayed; Name=2; IsoId=Q9R0M5-2; Sequence=VSP_009597; Name=3; IsoId=Q9R0M5-3; Sequence=VSP_009595, VSP_009596; Detected in kidney and liver, and at lower levels in heart, brain and testis. [Isoform 3]: May be due to intron retention. Belongs to the thiamine pyrophosphokinase family. nucleotide binding thiamine diphosphokinase activity ATP binding thiamine metabolic process thiamine diphosphate biosynthetic process kinase activity phosphorylation transferase activity thiamine binding uc009bsq.1 uc009bsq.2 uc009bsq.3 
ENSMUST00000067912.8 Klf2 ENSMUST00000067912.8 Kruppel-like transcription factor 2 (lung) (from RefSeq NM_008452.2) B2RS60 ENSMUST00000067912.1 ENSMUST00000067912.2 ENSMUST00000067912.3 ENSMUST00000067912.4 ENSMUST00000067912.5 ENSMUST00000067912.6 ENSMUST00000067912.7 KLF2_MOUSE Lklf NM_008452 Q60843 uc009mfq.1 uc009mfq.2 uc009mfq.3 uc009mfq.4 Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (By similarity). Interacts with WWP1. Nucleus Predominant expression in the lungs and spleen. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin cell morphogenesis RNA polymerase II transcription factor activity, sequence-specific DNA binding in utero embryonic development nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription from RNA polymerase II promoter negative regulation of interleukin-6 production erythrocyte homeostasis response to laminar fluid shear stress multicellular organism growth positive regulation of transcription from RNA polymerase II promoter in response to stress regulation of gene expression, epigenetic erythrocyte maturation positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of protein metabolic process Type I pneumocyte differentiation cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to organic cyclic compound cellular response to cycloheximide cellular response to fluid shear stress cellular response to laminar fluid shear stress cellular stress response to acid chemical cellular response to peptide negative regulation of sprouting angiogenesis uc009mfq.1 uc009mfq.2 uc009mfq.3 uc009mfq.4 
ENSMUST00000067918.12 Ppm1h ENSMUST00000067918.12 protein phosphatase 1H (PP2C domain containing), transcript variant 1 (from RefSeq NM_001110218.1) ENSMUST00000067918.1 ENSMUST00000067918.10 ENSMUST00000067918.11 ENSMUST00000067918.2 ENSMUST00000067918.3 ENSMUST00000067918.4 ENSMUST00000067918.5 ENSMUST00000067918.6 ENSMUST00000067918.7 ENSMUST00000067918.8 ENSMUST00000067918.9 Kiaa1157 NM_001110218 PPM1H_MOUSE Q3UD05 Q3UYC0 Q3V3H5 Q3V3Y7 Q571C9 Q7TMU7 Q8BYE6 uc007hgh.1 uc007hgh.2 uc007hgh.3 uc007hgh.4 uc007hgh.5 Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UYC0-1; Sequence=Displayed; Name=2; IsoId=Q3UYC0-2; Sequence=VSP_025121, VSP_025122; Belongs to the PP2C family. Sequence=BAD90185.1; Type=Erroneous initiation; Evidence=; Sequence=BAE29457.1; Type=Erroneous initiation; Evidence=; Sequence=BAE43270.1; Type=Erroneous initiation; Evidence=; catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity [pyruvate dehydrogenase (lipoamide)] phosphatase activity nucleus nucleoplasm cytoplasm mitochondrion protein dephosphorylation hydrolase activity synapse glutamatergic synapse positive regulation of pyruvate dehydrogenase activity uc007hgh.1 uc007hgh.2 uc007hgh.3 uc007hgh.4 uc007hgh.5 
ENSMUST00000067924.13 Lrrc8c ENSMUST00000067924.13 leucine rich repeat containing 8 family, member C (from RefSeq NM_133897.2) Ad158 ENSMUST00000067924.1 ENSMUST00000067924.10 ENSMUST00000067924.11 ENSMUST00000067924.12 ENSMUST00000067924.2 ENSMUST00000067924.3 ENSMUST00000067924.4 ENSMUST00000067924.5 ENSMUST00000067924.6 ENSMUST00000067924.7 ENSMUST00000067924.8 ENSMUST00000067924.9 Fad158 LRC8C_MOUSE Lrrc8c NM_133897 Q3TEP9 Q8C296 Q8R0N7 Q8R3G5 Q8R502 uc008ylf.1 uc008ylf.2 uc008ylf.3 Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). May play a role in adipogenesis (PubMed:15184384, PubMed:15564382, PubMed:21804215). Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324, ChEBI:CHEBI:16382; Evidence=; Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328, ChEBI:CHEBI:507393; Evidence=; Reaction=2',3'-cGAMP(out) = 2',3'-cGAMP(in); Xref=Rhea:RHEA:66320, ChEBI:CHEBI:143093; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66321; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:66322; Evidence=; Heterohexamer (PubMed:29769723). Oligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8D and/or LRRC8E) to form a heterohexamer (PubMed:24782309, PubMed:29769723). Detected in a channel complex that contains LRRC8A, LRRC8C and LRRC8E (By similarity). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable). Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. Expressed at very low levels in adipose tissue. Induced during the earliest stages of adipogenesis. The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins. The cytoplasmic N-terminus preceding the first transmembrane (residues 1-22) regulates volume-regulated anion channel (VRAC) conductance, ion permeability and inactivation gating. Mice do not show remarkable changes in body weight or the weight of white adipose tissue on a chow diet, but display significantly lower body weights and fat mass than wild-type mice when fed a high-fat diet. Moreover, improved insulin resistance induced by the high-fat diet is observed. Belongs to the LRRC8 family. volume-sensitive anion channel activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane ion transport inorganic anion transport taurine transport aspartate transport membrane integral component of membrane protein hexamerization ion channel complex fat cell differentiation cellular response to osmotic stress anion transmembrane transport uc008ylf.1 uc008ylf.2 uc008ylf.3 
ENSMUST00000067925.8 Hmgb2 ENSMUST00000067925.8 high mobility group box 2, transcript variant 2 (from RefSeq NM_008252.3) ENSMUST00000067925.1 ENSMUST00000067925.2 ENSMUST00000067925.3 ENSMUST00000067925.4 ENSMUST00000067925.5 ENSMUST00000067925.6 ENSMUST00000067925.7 HMGB2_MOUSE Hmg2 NM_008252 P30681 Q3UXT1 Q9EQD5 uc009lsx.1 uc009lsx.2 uc009lsx.3 uc009lsx.4 Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non- canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (PubMed:9184213). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (PubMed:19890330). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (By similarity). Has antimicrobial activity in gastrointestinal epithelial tissues (By similarity). Involved in inflammatory response to antigenic stimulus coupled with pro- inflammatory activity (PubMed:25306442). May play a role in germ cell differentiation (PubMed:11262228). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (PubMed:24391977). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (PubMed:19805379). Interacts with POU2F2, POU2F1 and POU3F1 (PubMed:7720710). Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2 (PubMed:9184213). Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET (By similarity). Interacts with LEF1 (PubMed:19805379). P30681; P27782: Lef1; NbExp=2; IntAct=EBI-6910056, EBI-984464; Nucleus Chromosome Cytoplasm Secreted Widely expressed in embryo. In adult mainly expressed in lymphoid organs and testes (PubMed:11262228). Expressed in primary spermatocytes. Expressed in the superficial zone of articular cartilage (PubMed:19805379). Both, HMG box 1 and HMG box 2, show antimicrobial activity. Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys- 106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB2 (HMGB2C23hC45hC106h), 2- disulfide HMGB2 (HMGB2C23-C45C106h) and 3- sulfonyl HMGB2 (HMGB2C23soC45soC106so). Viable, with severe reduction of sperm production in males. Belongs to the HMGB family. nuclear chromatin condensed chromosome enhancer sequence-specific DNA binding positive regulation of endothelial cell proliferation immune system process inflammatory response to antigenic stimulus DNA binding damaged DNA binding double-stranded DNA binding transcription coactivator activity protein binding extracellular region extracellular space cell nucleus chromosome nucleolus cytoplasm DNA topological change DNA recombination regulation of transcription from RNA polymerase II promoter chemotaxis inflammatory response spermatogenesis spermatid nucleus differentiation transcription factor binding DNA binding, bending male gonad development positive regulation of gene expression negative regulation of gene expression protein domain specific binding positive regulation of nuclease activity response to lipopolysaccharide positive regulation of interferon-beta production macromolecular complex chemoattractant activity positive regulation of DNA binding transcription regulatory region DNA binding non-sequence-specific DNA binding, bending innate immune response positive regulation of innate immune response positive regulation of erythrocyte differentiation positive regulation of megakaryocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm response to steroid hormone regulation of neurogenesis RAGE receptor binding defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive chemotaxis cell chemotaxis cellular response to lipopolysaccharide regulation of stem cell proliferation supercoiled DNA binding negative regulation of extrinsic apoptotic signaling pathway via death domain receptors uc009lsx.1 uc009lsx.2 uc009lsx.3 uc009lsx.4 
ENSMUST00000067927.9 Msra ENSMUST00000067927.9 methionine sulfoxide reductase A, transcript variant 1 (from RefSeq NM_026322.4) ENSMUST00000067927.1 ENSMUST00000067927.2 ENSMUST00000067927.3 ENSMUST00000067927.4 ENSMUST00000067927.5 ENSMUST00000067927.6 ENSMUST00000067927.7 ENSMUST00000067927.8 MSRA_MOUSE NM_026322 Q5EBQ7 Q91WK9 Q9D6Y7 Q9DCY2 uc288vec.1 uc288vec.2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Reaction=[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]; Xref=Rhea:RHEA:14217, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12315, ChEBI:CHEBI:15377, ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:44120, ChEBI:CHEBI:50058; EC=1.8.4.11; Evidence=; Reaction=[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]- dithiol + L-methionine (S)-S-oxide; Xref=Rhea:RHEA:19993, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57844, ChEBI:CHEBI:58772; EC=1.8.4.11; Evidence=; [Isoform 1]: Mitochondrion. [Isoform 2]: Cytoplasm. Nucleus. Membrane; Lipid- anchor. Event=Alternative splicing, Alternative initiation; Named isoforms=4; Comment=Only about 25% of mRNAs are initiated at the mitochondrial isoform 1 codon. According to PubMed:15924425, differential subcellular targeting is not due alternative initiation. ; Name=1; IsoId=Q9D6Y7-1; Sequence=Displayed; Name=2; IsoId=Q9D6Y7-2; Sequence=VSP_042133; Name=3; IsoId=Q9D6Y7-3; Sequence=VSP_041409; Name=4; IsoId=Q9D6Y7-4; Sequence=VSP_041408; [Isoform 1]: Mitochondrial. [Isoform 2]: Cytoplasmic. Produced by alternative initiation. Belongs to the MsrA Met sulfoxide reductase family. nucleus nucleoplasm cytoplasm mitochondrion cytosol aging peptide-methionine (S)-S-oxide reductase activity actin cytoskeleton membrane oxidoreductase activity cellular response to oxidative stress L-methionine-(S)-S-oxide reductase activity oxidation-reduction process uc288vec.1 uc288vec.2 
ENSMUST00000067931.7 Vmac ENSMUST00000067931.7 vimentin-type intermediate filament associated coiled-coil protein, transcript variant 1 (from RefSeq NM_178926.4) ENSMUST00000067931.1 ENSMUST00000067931.2 ENSMUST00000067931.3 ENSMUST00000067931.4 ENSMUST00000067931.5 ENSMUST00000067931.6 NM_178926 Q3UKV2 Q8BP01 VMAC_MOUSE uc008dcx.1 uc008dcx.2 uc008dcx.3 uc008dcx.4 Cytoplasm Note=Colocalizes with vimentin-type intermediate filaments. cytoplasm biological_process type III intermediate filament uc008dcx.1 uc008dcx.2 uc008dcx.3 uc008dcx.4 
ENSMUST00000067935.11 Vps37d ENSMUST00000067935.11 vacuolar protein sorting 37D, transcript variant 3 (from RefSeq NR_189596.1) ENSMUST00000067935.1 ENSMUST00000067935.10 ENSMUST00000067935.2 ENSMUST00000067935.3 ENSMUST00000067935.4 ENSMUST00000067935.5 ENSMUST00000067935.6 ENSMUST00000067935.7 ENSMUST00000067935.8 ENSMUST00000067935.9 NR_189596 Q80UX4 Q810I0 Q8C1V8 VP37D_MOUSE Vps37d Wbscr24 uc008zxr.1 uc008zxr.2 uc008zxr.3 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity). Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101 and MVB12A. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry (By similarity). Late endosome membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q810I0-1; Sequence=Displayed; Name=2 ; IsoId=Q810I0-2; Sequence=VSP_052739; Belongs to the VPS37 family. Sequence=AAH44789.1; Type=Erroneous initiation; Evidence=; ESCRT I complex molecular_function endosome protein targeting to membrane protein targeting to vacuole protein transport membrane late endosome membrane endosome transport via multivesicular body sorting pathway ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway intracellular membrane-bounded organelle uc008zxr.1 uc008zxr.2 uc008zxr.3 
ENSMUST00000067940.3 1700013H16Rik ENSMUST00000067940.3 RIKEN cDNA 1700013H16 gene (from RefSeq NM_001200013.1) 1700013H16Rik ENSMUST00000067940.1 ENSMUST00000067940.2 NM_001200013 Q9DAC5 Q9DAC5_MOUSE uc009tfj.1 uc009tfj.2 uc009tfj.3 Belongs to the XLR/SYCP3 family. synaptonemal complex XY body protein binding nucleus nucleolus spermatogenesis spermatid development meiotic cell cycle chromatin uc009tfj.1 uc009tfj.2 uc009tfj.3 
ENSMUST00000067947.7 Rock1 ENSMUST00000067947.7 Rho-associated coiled-coil containing protein kinase 1 (from RefSeq NM_009071.2) ENSMUST00000067947.1 ENSMUST00000067947.2 ENSMUST00000067947.3 ENSMUST00000067947.4 ENSMUST00000067947.5 ENSMUST00000067947.6 NM_009071 P70335 Q8C3G4 Q8C7H0 ROCK1_MOUSE uc008eaq.1 uc008eaq.2 uc008eaq.3 Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:19036714, PubMed:19181962). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:19036714, PubMed:19181962). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By similarity). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (PubMed:20008297). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (PubMed:30115939). Promotes keratinocyte terminal differentiation (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (PubMed:21768292). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (PubMed:15753128). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by RHOA binding. Inhibited by Y-27632 (By similarity). Homodimer (By similarity). Interacts with RHOA (activated by GTP), RHOB, RHOC, GEM, MYLC2B, RHOE, PPP1R12A, LIMK1, LIMK2, TSG101, CHORDC1, DAPK3, PFN1 and JIP3 (By similarity). Interacts with FHOD1 in a Src-dependent manner (By similarity). Interacts with PTEN. Interacts with ITGB1BP1 (via N-terminus and PTB domain). Interacts with SHROOM3 (PubMed:22493320). P70335; P61588: Rnd3; NbExp=7; IntAct=EBI-989293, EBI-6930266; Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Golgi apparatus membrane ; Peripheral membrane protein Cell projection, bleb Cytoplasm, cytoskeleton Cell membrane Cell projection, lamellipodium Cell projection, ruffle Note=A small proportion is associated with Golgi membranes (By similarity). Associated with the mother centriole and an intercentriolar linker (PubMed:16741948). Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers (PubMed:16741948). Localizes at the cell membrane in an ITGB1BP1- dependent manner (PubMed:16741948). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70335-1; Sequence=Displayed; Name=2; IsoId=P70335-2; Sequence=VSP_010448; Highly expressed in brain, heart, lung, liver, stomach, spleen, kidney, testis, muscle, embryo and placenta. The C-terminal auto-inhibitory domain interferes with kinase activity. RHOA binding leads to a conformation change and activation of the kinase. Truncated ROCK1 is constitutively activated. Autophosphorylated on serine and threonine residues. Cleaved by caspase-3 during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing (By similarity). Mice exhibit both EOB (eyes open at birth) and omphalocele phenotypes as a result of disorganization of actomyosin cables in the eyelid epithelium and defective actin assembly in the umbilical ring. [Isoform 2]: May be due to a competing donor splice site. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Sequence=AAH57154.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC34154.1; Type=Erroneous initiation; Evidence=; Golgi membrane nucleotide binding mitotic cytokinesis ruffle apical constriction protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm Golgi apparatus centriole cytoskeleton plasma membrane protein phosphorylation apoptotic process cytoskeleton organization leukocyte cell-cell adhesion I-kappaB kinase/NF-kappaB signaling Rho protein signal transduction cytoplasmic stress granule positive regulation of autophagy positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of endopeptidase activity membrane kinase activity phosphorylation negative regulation of angiogenesis transferase activity Rho GTPase binding GTP-Rho binding peptidyl-serine phosphorylation peptidyl-threonine phosphorylation aspartic-type endopeptidase inhibitor activity membrane to membrane docking lamellipodium actin cytoskeleton organization cortical actin cytoskeleton organization actomyosin structure organization neuron projection development bleb bleb assembly negative regulation of protein binding regulation of actin cytoskeleton organization regulation of actin filament-based process negative regulation of myosin-light-chain-phosphatase activity intracellular signal transduction cell projection positive regulation of MAPK cascade negative regulation of neuron apoptotic process regulation of keratinocyte differentiation regulation of neuron differentiation metal ion binding embryonic morphogenesis leukocyte migration leukocyte tethering or rolling myoblast migration positive regulation of focal adhesion assembly mRNA destabilization response to transforming growth factor beta Rho-dependent protein serine/threonine kinase activity protein localization to plasma membrane regulation of blood vessel diameter positive regulation of beta-amyloid clearance regulation of synaptic vesicle endocytosis regulation of cell junction assembly negative regulation of beta-amyloid formation negative regulation of amyloid precursor protein catabolic process regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly positive regulation of connective tissue replacement response to angiotensin uc008eaq.1 uc008eaq.2 uc008eaq.3 
ENSMUST00000067976.9 Ppp2r5a ENSMUST00000067976.9 protein phosphatase 2, regulatory subunit B', alpha (from RefSeq NM_144880.4) 2A5A_MOUSE ENSMUST00000067976.1 ENSMUST00000067976.2 ENSMUST00000067976.3 ENSMUST00000067976.4 ENSMUST00000067976.5 ENSMUST00000067976.6 ENSMUST00000067976.7 ENSMUST00000067976.8 NM_144880 Q6PD03 Q8R1U7 uc007eci.1 uc007eci.2 uc007eci.3 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1 (By similarity). Cytoplasm Nucleus Chromosome, centromere Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase (By similarity). Widely expressed with highest levels in thymus and ovary. Belongs to the phosphatase 2A regulatory subunit B56 family. Sequence=AAH23062.1; Type=Erroneous initiation; Evidence=; protein phosphatase type 2A complex chromosome, centromeric region phosphoprotein phosphatase activity protein binding nucleus chromosome cytoplasm centrosome cytosol protein dephosphorylation signal transduction membrane protein phosphatase regulator activity kinase binding Z disc M band regulation of protein autophosphorylation positive regulation of protein dephosphorylation regulation of phosphoprotein phosphatase activity protein phosphatase activator activity negative regulation of lipid kinase activity negative regulation of protein localization to plasma membrane uc007eci.1 uc007eci.2 uc007eci.3 
ENSMUST00000067980.12 Amy1 ENSMUST00000067980.12 amylase 1, salivary, transcript variant 2 (from RefSeq NM_001110505.1) AMY1_MOUSE Amy-1-a Amy1a ENSMUST00000067980.1 ENSMUST00000067980.10 ENSMUST00000067980.11 ENSMUST00000067980.2 ENSMUST00000067980.3 ENSMUST00000067980.4 ENSMUST00000067980.5 ENSMUST00000067980.6 ENSMUST00000067980.7 ENSMUST00000067980.8 ENSMUST00000067980.9 NM_001110505 P00687 Q921Y7 uc008rbb.1 uc008rbb.2 uc008rbb.3 uc008rbb.4 Reaction=Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D- glucose units.; EC=3.2.1.1; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence=; Note=Binds 1 Cl(-) ion per subunit. ; Monomer. Secreted. Expressed in liver and saliva. Hepatic and salivary alpha-amylases are encoded by the same gene; however, their mRNAs have different 5'-UTR sequences. Belongs to the glycosyl hydrolase 13 family. catalytic activity alpha-amylase activity calcium ion binding extracellular region extracellular space carbohydrate metabolic process metabolic process response to bacterium carbohydrate catabolic process amylase activity hydrolase activity hydrolase activity, acting on glycosyl bonds chloride ion binding cation binding metal ion binding uc008rbb.1 uc008rbb.2 uc008rbb.3 uc008rbb.4 
ENSMUST00000067984.9 Mtnr1a ENSMUST00000067984.9 melatonin receptor 1A (from RefSeq NM_008639.3) ENSMUST00000067984.1 ENSMUST00000067984.2 ENSMUST00000067984.3 ENSMUST00000067984.4 ENSMUST00000067984.5 ENSMUST00000067984.6 ENSMUST00000067984.7 ENSMUST00000067984.8 MTR1A_MOUSE NM_008639 Q61184 uc009loq.1 uc009loq.2 uc009loq.3 High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway circadian rhythm melatonin receptor activity membrane integral component of membrane hormone binding neuronal cell body receptor complex negative regulation of insulin secretion organic cyclic compound binding uc009loq.1 uc009loq.2 uc009loq.3 
ENSMUST00000067987.3 Gm9955 ENSMUST00000067987.3 Gm9955 (from geneSymbol) ENSMUST00000067987.1 ENSMUST00000067987.2 uc289oka.1 uc289oka.2 uc289oka.3 uc289oka.1 uc289oka.2 uc289oka.3 
ENSMUST00000067990.8 Defb42 ENSMUST00000067990.8 defensin beta 42, transcript variant 1 (from RefSeq NM_001034910.4) DFB42_MOUSE Defb42 Defb44 ENSMUST00000067990.1 ENSMUST00000067990.2 ENSMUST00000067990.3 ENSMUST00000067990.4 ENSMUST00000067990.5 ENSMUST00000067990.6 ENSMUST00000067990.7 NM_001034910 Q4FZ54 Q8BVB5 uc007uhf.1 uc007uhf.2 uc007uhf.3 uc007uhf.4 Has bactericidal activity (By similarity). May play a role in the antimicrobial protection of sperm and urogenital tract epithelia (PubMed:16023745). Secreted Epididymis-specific, with highest levels in the initial segment and distal caput. By androgens. Belongs to the beta-defensin family. molecular_function cellular_component extracellular region defense response biological_process defense response to bacterium uc007uhf.1 uc007uhf.2 uc007uhf.3 uc007uhf.4 
ENSMUST00000067996.7 Set ENSMUST00000067996.7 SET nuclear oncogene, transcript variant 2 (from RefSeq NM_001204875.2) A2BE95 ENSMUST00000067996.1 ENSMUST00000067996.2 ENSMUST00000067996.3 ENSMUST00000067996.4 ENSMUST00000067996.5 ENSMUST00000067996.6 NM_001204875 Q9CY82 Q9D0A9 Q9EQU5 Q9Z181 SET_MOUSE uc008jay.1 uc008jay.2 uc008jay.3 uc008jay.4 Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF- mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity). Headphone-shaped homodimer. Isoform 1 and isoform 2 interact directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex. Isoform 1 and isoform 2 interact also with histones. Isoform 2 is a omponent of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1, but not NME2 or TREX2. Within this complex, directly interacts with ANP32A, NME1, HMGB2 and TREX1; the interaction with ANP32A is enhanced after cleavage. Interacts with APBB1, CHTOP, SETBP1, SGO1. Cytoplasm, cytosol Endoplasmic reticulum Nucleus, nucleoplasm Note=In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=TAF-I alpha; IsoId=Q9EQU5-1; Sequence=Displayed; Name=2; Synonyms=TAF-I beta; IsoId=Q9EQU5-2; Sequence=VSP_009869; Name=3; IsoId=Q9EQU5-3; Sequence=VSP_009870, VSP_009871; A long alpha helix in the N-terminus mediates dimerization, while the earmuff domain is responsible for core histone and dsDNA binding. The C-terminal acidic domain mediates the inhibition of histone acetyltransferases and is required for the DNA replication stimulatory activity (By similarity). Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group. N-terminus of isoform 1 is methylated by METTL11A/NTM1. Mainly trimethylated. [Isoform 2]: Cleaved after Lys-176 by GZMA. The cleavage inhibits its nucleosome assembly activity and disrupts the inhibition on NME1 (By similarity). Belongs to the nucleosome assembly protein (NAP) family. DNA binding nucleus nucleoplasm cytoplasm endoplasmic reticulum lipid particle cytosol nucleosome assembly macromolecular complex negative regulation of neuron apoptotic process negative regulation of transcription, DNA-templated perinuclear region of cytoplasm uc008jay.1 uc008jay.2 uc008jay.3 uc008jay.4 
ENSMUST00000068004.13 Pcx ENSMUST00000068004.13 pyruvate carboxylase, transcript variant 1 (from RefSeq NM_001162946.1) E9QPD7 E9QPD7_MOUSE ENSMUST00000068004.1 ENSMUST00000068004.10 ENSMUST00000068004.11 ENSMUST00000068004.12 ENSMUST00000068004.2 ENSMUST00000068004.3 ENSMUST00000068004.4 ENSMUST00000068004.5 ENSMUST00000068004.6 ENSMUST00000068004.7 ENSMUST00000068004.8 ENSMUST00000068004.9 NM_001162946 Pcx uc008gaf.1 uc008gaf.2 uc008gaf.3 Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Reaction=ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate; Xref=Rhea:RHEA:20844, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=6.4.1.1; Evidence=; Name=biotin; Xref=ChEBI:CHEBI:57586; Evidence= Carbohydrate biosynthesis; gluconeogenesis. nucleotide binding catalytic activity pyruvate carboxylase activity ATP binding mitochondrion pyruvate metabolic process gluconeogenesis biotin binding ligase activity metal ion binding uc008gaf.1 uc008gaf.2 uc008gaf.3 
ENSMUST00000068006.9 Mocos ENSMUST00000068006.9 molybdenum cofactor sulfurase (from RefSeq NM_026779.1) ENSMUST00000068006.1 ENSMUST00000068006.2 ENSMUST00000068006.3 ENSMUST00000068006.4 ENSMUST00000068006.5 ENSMUST00000068006.6 ENSMUST00000068006.7 ENSMUST00000068006.8 MOCOS_MOUSE NM_026779 Q14CH1 uc008egy.1 uc008egy.2 uc008egy.3 Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. Reaction=AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin; Xref=Rhea:RHEA:42636, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:35235, ChEBI:CHEBI:57972, ChEBI:CHEBI:71302, ChEBI:CHEBI:82685; EC=2.8.1.9; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily. catalytic activity cellular_component Mo-molybdopterin cofactor biosynthetic process Mo-molybdopterin cofactor sulfurase activity transferase activity lyase activity molybdenum ion binding pyridoxal phosphate binding molybdopterin cofactor metabolic process uc008egy.1 uc008egy.2 uc008egy.3 
ENSMUST00000068023.8 Cadm4 ENSMUST00000068023.8 cell adhesion molecule 4 (from RefSeq NM_153112.3) CADM4_MOUSE ENSMUST00000068023.1 ENSMUST00000068023.2 ENSMUST00000068023.3 ENSMUST00000068023.4 ENSMUST00000068023.5 ENSMUST00000068023.6 ENSMUST00000068023.7 Igsf4c NM_153112 Necl4 Q8R464 Tsll2 uc009fps.1 uc009fps.2 uc009fps.3 Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity. Monomer and homodimer. Membrane ; Single-pass type I membrane protein Expressed in the brain and several organs including the kidney and liver. N-glycosylated. Belongs to the nectin family. regulation of protein phosphorylation negative regulation of protein phosphorylation cell adhesion negative regulation of peptidyl-threonine phosphorylation membrane integral component of membrane protein phosphatase binding negative regulation of vascular endothelial growth factor receptor signaling pathway receptor tyrosine kinase binding cell leading edge regulation of Rac protein signal transduction regulation of cell proliferation vascular endothelial growth factor receptor 1 binding vascular endothelial growth factor receptor 2 binding cell-cell contact zone negative regulation of peptidyl-tyrosine phosphorylation regulation of wound healing negative regulation of vascular endothelial growth factor signaling pathway regulation of cell motility uc009fps.1 uc009fps.2 uc009fps.3 
ENSMUST00000068025.13 Klhl18 ENSMUST00000068025.13 kelch-like 18, transcript variant 1 (from RefSeq NM_177771.5) E9Q4F2 ENSMUST00000068025.1 ENSMUST00000068025.10 ENSMUST00000068025.11 ENSMUST00000068025.12 ENSMUST00000068025.2 ENSMUST00000068025.3 ENSMUST00000068025.4 ENSMUST00000068025.5 ENSMUST00000068025.6 ENSMUST00000068025.7 ENSMUST00000068025.8 ENSMUST00000068025.9 KLH18_MOUSE NM_177771 uc009rua.1 uc009rua.2 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis (By similarity). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (By similarity). Regulates light- and dark-dependent alpha-transducin localization changes in rod photoreceptors through UNC119 ubiquitination and degradation (PubMed:31696965). Preferentially ubiquitinates the unphosphorylated form of UNC119 over the phosphorylated form (PubMed:31696965). In the presence of UNC119, under dark-adapted conditions alpha-transducin mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light (PubMed:31696965). Protein modification; protein ubiquitination. Interacts with AURKA (By similarity). Interacts (via BTB domain) with CUL3 (By similarity). Interacts (via kelch repeats) with UNC119 (PubMed:31696965). Predominantly expressed in maturing and mature retinal photoreceptor cells. Retina-specific gene disruption leads to decreased light response in rod photoreceptor cells and mislocalization of alpha-transducin from the outer segment to the inner part of rod photoreceptors. protein ubiquitination positive regulation of mitotic cell cycle phase transition uc009rua.1 uc009rua.2 
ENSMUST00000068031.8 Top2a ENSMUST00000068031.8 topoisomerase (DNA) II alpha (from RefSeq NM_011623.2) E9PX08 ENSMUST00000068031.1 ENSMUST00000068031.2 ENSMUST00000068031.3 ENSMUST00000068031.4 ENSMUST00000068031.5 ENSMUST00000068031.6 ENSMUST00000068031.7 NM_011623 Q01320 TOP2A_MOUSE Top-2 Top2 uc007lid.1 uc007lid.2 uc007lid.3 Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:1331984). May play a role in regulating the period length of BMAL1 transcriptional oscillation (PubMed:24321095). Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). Homodimer (By similarity). Interacts with COPS5 (By similarity). Interacts with RECQL5; this stimulates DNA decatenation (By similarity). Interacts with SETMAR; stimulates the topoisomerase activity (By similarity). Interacts with DHX9; this interaction occurs in a E2 enzyme UBE2I- and RNA-dependent manner, negatively regulates DHX9-mediated double-stranded DNA and RNA duplex helicase activity and stimulates TOP2A-mediated supercoiled DNA relaxation activity (By similarity). Interacts with HNRNPU (via C-terminus); this interaction protects the topoisomerase TOP2A from degradation and positively regulates the relaxation of supercoiled DNA in a RNA-dependent manner (By similarity). Interacts with MCM3AP (By similarity). Interacts with ERCC6 (By similarity). Interacts with PLSCR1 (By similarity). Interacts with GCNA; this interaction allows the resolution of topoisomerase II (TOP2A) DNA-protein cross-links (PubMed:31839538). Q01320; Q3TKT4: Smarca4; NbExp=3; IntAct=EBI-642809, EBI-1210244; Cytoplasm Nucleus, nucleoplasm Nucleus Nucleus, nucleolus Phosphorylation has no effect on catalytic activity (By similarity). However, phosphorylation at Ser-1105 by CSNK1D/CK1 promotes DNA cleavable complex formation (By similarity). Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils. Belongs to the type II topoisomerase family. nucleotide binding nuclear chromosome magnesium ion binding resolution of meiotic recombination intermediates condensed chromosome sister chromatid segregation hematopoietic progenitor cell differentiation DNA binding chromatin binding DNA topoisomerase activity DNA topoisomerase type II (ATP-hydrolyzing) activity protein kinase C binding protein binding ATP binding nucleus nucleoplasm nucleolus centriole DNA metabolic process DNA topological change DNA ligation cellular response to DNA damage stimulus chromosome segregation female meiotic division protein C-terminus binding DNA-dependent ATPase activity drug binding DNA binding, bending DNA topoisomerase complex (ATP-hydrolyzing) isomerase activity viral integration complex enzyme binding chromosome condensation apoptotic chromosome condensation macromolecular complex embryonic cleavage regulation of circadian rhythm protein homodimerization activity histone deacetylase binding positive regulation of apoptotic process ubiquitin binding sequence-specific DNA binding mitotic DNA integrity checkpoint positive regulation of single stranded viral RNA replication via double stranded DNA intermediate positive regulation of transcription from RNA polymerase II promoter metal ion binding protein heterodimerization activity rhythmic process female meiosis chromosome separation negative regulation of DNA duplex unwinding ribonucleoprotein complex uc007lid.1 uc007lid.2 uc007lid.3 
ENSMUST00000068054.9 Stambp ENSMUST00000068054.9 STAM binding protein, transcript variant 2 (from RefSeq NM_024239.2) Amsh ENSMUST00000068054.1 ENSMUST00000068054.2 ENSMUST00000068054.3 ENSMUST00000068054.4 ENSMUST00000068054.5 ENSMUST00000068054.6 ENSMUST00000068054.7 ENSMUST00000068054.8 NM_024239 Q3UTI9 Q9CQ26 STABP_MOUSE uc009cnt.1 uc009cnt.2 uc009cnt.3 uc009cnt.4 Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Inhibited by N-ethylmaleimide. Interacts with STAM. Interacts with SMAD6 and SMAD7. Interacts with CHMP3; the interaction appears to relieve the autoinhibition of CHMP3. Interacts with SMURF2 and RNF11; this interaction promotes ubiquitination. Nucleus Membrane ; Peripheral membrane protein Cytoplasm Early endosome Expressed in brain. Highest expression at 18.5 dpc, followed by a gradual decrease. The JAMM motif is essential for the protease activity. Phosphorylated after BMP type I receptor activation. Ubiquitinated by SMURF2 in the presence of RNF11. Mice show a loss of neurons and apoptotic cells in the hippocampus. Belongs to the peptidase M67C family. mitotic cytokinesis thiol-dependent ubiquitin-specific protease activity nucleus nucleoplasm cytoplasm endosome cytosol plasma membrane proteolysis peptidase activity metallopeptidase activity negative regulation of phosphatidylinositol 3-kinase signaling membrane protein deubiquitination hydrolase activity protein domain specific binding cleavage furrow negative regulation of neuron apoptotic process negative regulation of Ras protein signal transduction metal ion binding Lys63-specific deubiquitinase activity protein K63-linked deubiquitination uc009cnt.1 uc009cnt.2 uc009cnt.3 uc009cnt.4 
ENSMUST00000068056.12 Ddx39b ENSMUST00000068056.12 DEAD box helicase 39b, transcript variant 1 (from RefSeq NM_019693.3) Bat1 Bat1a DX39B_MOUSE ENSMUST00000068056.1 ENSMUST00000068056.10 ENSMUST00000068056.11 ENSMUST00000068056.2 ENSMUST00000068056.3 ENSMUST00000068056.4 ENSMUST00000068056.5 ENSMUST00000068056.6 ENSMUST00000068056.7 ENSMUST00000068056.8 ENSMUST00000068056.9 NM_019693 Q8HW97 Q9Z1N5 Uap56 uc008cha.1 uc008cha.2 uc008cha.3 Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [] reporting a stimulatory effect. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Homodimer, and heterodimer with DDX39A. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex bridges ALYREF/THOC4 and the THO complex, and, in a ATP-dependent manner, ALYREF/THOC4 and SARNP/CIP29. Component of the spliceosome. Interacts directly with U2AF2. Interacts with RBM8A, RNPS1 and SRRM1, FYTTD1/UIF, THOC1, MX1 and POLDIP3. Interacts with LUZP4. Nucleus Nucleus speckle Cytoplasm Note=Can translocate to the cytoplasm in the presence of MX1. The helicase C-terminal domain mediates interaction with ALYREF/THOC4. Belongs to the DEAD box helicase family. DECD subfamily. nucleotide binding spliceosomal complex assembly transcription export complex mRNA splicing, via spliceosome liver development nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus spliceosomal complex U4 snRNP U6 snRNP cytoplasm mRNA processing mRNA export from nucleus RNA-dependent ATPase activity RNA splicing RNA secondary structure unwinding nuclear matrix nuclear speck hydrolase activity ATPase activity U6 snRNA binding U4 snRNA binding positive regulation of DNA-templated transcription, elongation macromolecular complex identical protein binding ATP-dependent protein binding macromolecular complex binding positive regulation of translation viral mRNA export from host cell nucleus mRNA transport positive regulation of cell growth involved in cardiac muscle cell development positive regulation of vascular smooth muscle cell proliferation negative regulation of DNA damage checkpoint positive regulation of DNA biosynthetic process uc008cha.1 uc008cha.2 uc008cha.3 
ENSMUST00000068058.14 Usp46 ENSMUST00000068058.14 ubiquitin specific peptidase 46, transcript variant 1 (from RefSeq NM_177561.4) ENSMUST00000068058.1 ENSMUST00000068058.10 ENSMUST00000068058.11 ENSMUST00000068058.12 ENSMUST00000068058.13 ENSMUST00000068058.2 ENSMUST00000068058.3 ENSMUST00000068058.4 ENSMUST00000068058.5 ENSMUST00000068058.6 ENSMUST00000068058.7 ENSMUST00000068058.8 ENSMUST00000068058.9 NM_177561 P62069 Q3ULU5 Q80V95 Q9H7U4 Q9H9T8 UBP46_MOUSE uc008xtg.1 uc008xtg.2 uc008xtg.3 Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (PubMed:19465912). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with WDR48. Interacts with WDR20. Interacts with DMWD. Component of the USP46/WDR20/WDR48 deubiquitinating complex. Cytoplasm Note=USP46/WDR48/WDR20 complex is predominantly cytoplasmic. Belongs to the peptidase C19 family. USP12/USP46 subfamily. behavioral fear response cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus cytosol proteolysis ubiquitin-dependent protein catabolic process behavior peptidase activity cysteine-type peptidase activity adult feeding behavior protein deubiquitination hydrolase activity regulation of synaptic transmission, GABAergic thiol-dependent ubiquitinyl hydrolase activity synapse metal ion binding behavioral response to ethanol positive regulation of T cell receptor signaling pathway righting reflex glutamatergic synapse ubiquitinyl hydrolase activity uc008xtg.1 uc008xtg.2 uc008xtg.3 
ENSMUST00000068063.4 Tgtp1 ENSMUST00000068063.4 T cell specific GTPase 1 (from RefSeq NM_011579.3) ENSMUST00000068063.1 ENSMUST00000068063.2 ENSMUST00000068063.3 Ifggb5 Irgb6 Mg21 NM_011579 Q60711 Q62293 Q8BN19 TGTP1_MOUSE uc007ipm.1 uc007ipm.2 uc007ipm.3 uc007ipm.4 uc007ipm.5 Involved in innate cell-autonomous resistance to intracellular pathogens, such as Toxoplasma gondii (PubMed:19265156, PubMed:20109161, PubMed:24563254). During avirulent type II T. gondii infection, recruited to the parasitophorous vacuole (PV) membrane, leading to PV vesiculation and rupture, and subsequent digestion of the parasite within the cytosol (PubMed:19265156, PubMed:24563254). Not recruited to virulent type I T. gondii PV membrane (PubMed:19265156). May confer an antiviral state for vesicular stomatitis virus (PubMed:9725230). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; Cytoplasm Endoplasmic reticulum Golgi apparatus Note=In astrocytes stimulated with IFNG or TNF, diffuse cytoplasmic localization decreases and the protein partially relocalizes to the endoplasmic reticulum and Golgi apparatus (PubMed:19285957). Due to sequence similarity with Tgtp2, it is impossible to assign unambiguously experimental data published in the literature to Tgtp1 or Tgtp2 gene (Probable). Expressed in thymus and lymph nodes, predominantly T-cells. Not expressed by immature CD4(+) CD8(+) thymocytes (at protein level) (PubMed:7836757). Expressed in IFNG-stimulated macrophages (PubMed:7884320). Expressed at low levels in unstimulated astrocytes (PubMed:19285957). Due to sequence similarity with Tgtp2, it is impossible to assign unambiguously experimental data published in the literature to Tgtp1 or Tgtp2 gene. In macrophages, up-regulated by IFNG, but not by IL2, IL4, IL10, nor TNF (PubMed:7884320). Up-regulated by IFNG in lymph node cells and thymocytes and other cell types (PubMed:7836757, PubMed:9725230, PubMed:24563254). In astrocytes, up-regulated by TNF and IFNG; when both cytokines are combined, the effect is synergistic (PubMed:19285957). Due to sequence similarity with Tgtp2, it is impossible to assign unambiguously experimental data published in the literature to Tgtp1 or Tgtp2 gene (Probable). Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. The gene Tgtp1 belongs to a large family of eutherian IFNG- inducible GTPases, called immunity-related p47 GTPases, which comprises a variable amount of paralogs depending upon the species studied. In C57BL/6J mice, there is over 20 genes, whereas humans have only one ortholog. Tgtp1 closest paralog is Tgtp2. Both genes encode identical proteins. At the nucleotide sequence level, their CDSs differ at only 4 positions. Consequently it is almost impossible to assign unambiguously to one gene or the other experimental data published in the literature. nucleotide binding immune system process GTPase activity GTP binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus defense response immune response response to virus response to bacterium membrane hydrolase activity response to interferon-gamma response to interferon-alpha cellular response to interferon-beta innate immune response uc007ipm.1 uc007ipm.2 uc007ipm.3 uc007ipm.4 uc007ipm.5 
ENSMUST00000068068.6 1700041G16Rik ENSMUST00000068068.6 1700041G16Rik (from geneSymbol) AK033542 ENSMUST00000068068.1 ENSMUST00000068068.2 ENSMUST00000068068.3 ENSMUST00000068068.4 ENSMUST00000068068.5 uc291ysm.1 uc291ysm.2 uc291ysm.3 uc291ysm.1 uc291ysm.2 uc291ysm.3 
ENSMUST00000068079.14 Zfp560 ENSMUST00000068079.14 zinc finger protein 560 (from RefSeq NM_001004190.3) ENSMUST00000068079.1 ENSMUST00000068079.10 ENSMUST00000068079.11 ENSMUST00000068079.12 ENSMUST00000068079.13 ENSMUST00000068079.2 ENSMUST00000068079.3 ENSMUST00000068079.4 ENSMUST00000068079.5 ENSMUST00000068079.6 ENSMUST00000068079.7 ENSMUST00000068079.8 ENSMUST00000068079.9 NM_001004190 Q3URI6 Q3URI6_MOUSE Zfp560 uc009oij.1 uc009oij.2 uc009oij.3 nucleic acid binding DNA binding cellular_component regulation of transcription, DNA-templated metal ion binding uc009oij.1 uc009oij.2 uc009oij.3 
ENSMUST00000068088.8 Tafa5 ENSMUST00000068088.8 TAFA chemokine like family member 5, transcript variant 2 (from RefSeq NM_134096.2) ENSMUST00000068088.1 ENSMUST00000068088.2 ENSMUST00000068088.3 ENSMUST00000068088.4 ENSMUST00000068088.5 ENSMUST00000068088.6 ENSMUST00000068088.7 Fam19a5 NM_134096 Q8C1V6 Q91WE9 TAFA5_MOUSE uc007xef.1 uc007xef.2 This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]. Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (PubMed:29453251, PubMed:29138422). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (PubMed:29138422). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (PubMed:29138422). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated through the GPCR FPR2 (PubMed:29138422). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (PubMed:29453251). Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91WE9-1; Sequence=Displayed; Name=2; IsoId=Q91WE9-2; Sequence=VSP_016069; Expressed in the subcutaneous, brown, epididymal and perirenal adipose tissue (at protein level). Repressed in epididymal adipose tissue of diet-induced obese mice or leptin receptor-deficient mice. [Isoform 2]: Contains a predicted signal peptide at positions 1-25. Belongs to the TAFA family. molecular_function cytokine activity cellular_component extracellular region extracellular space signal transduction biological_process uc007xef.1 uc007xef.2 
ENSMUST00000068106.5 Smim10l2a ENSMUST00000068106.5 small integral membrane protein 10 like 2A (from RefSeq NM_183030.2) 6330419J24Rik A0A0B4J1F8 A0A0B4J1F8_MOUSE ENSMUST00000068106.1 ENSMUST00000068106.2 ENSMUST00000068106.3 ENSMUST00000068106.4 NM_183030 Smim10l2a uc292ofy.1 uc292ofy.2 molecular_function cellular_component biological_process uc292ofy.1 uc292ofy.2 
ENSMUST00000068116.13 Lrrfip1 ENSMUST00000068116.13 leucine rich repeat (in FLII) interacting protein 1, transcript variant 3 (from RefSeq NM_001111312.1) ENSMUST00000068116.1 ENSMUST00000068116.10 ENSMUST00000068116.11 ENSMUST00000068116.12 ENSMUST00000068116.2 ENSMUST00000068116.3 ENSMUST00000068116.4 ENSMUST00000068116.5 ENSMUST00000068116.6 ENSMUST00000068116.7 ENSMUST00000068116.8 ENSMUST00000068116.9 G5E8E1 G5E8E1_MOUSE Lrrfip1 NM_001111312 uc007bzq.1 uc007bzq.2 uc007bzq.3 uc007bzq.4 Belongs to the LRRFIP family. regulation of transcription, DNA-templated uc007bzq.1 uc007bzq.2 uc007bzq.3 uc007bzq.4 
ENSMUST00000068135.13 Adamts8 ENSMUST00000068135.13 ADAM metallopeptidase with thrombospondin type 1 motif 8, transcript variant 1 (from RefSeq NM_013906.3) Adamts8 ENSMUST00000068135.1 ENSMUST00000068135.10 ENSMUST00000068135.11 ENSMUST00000068135.12 ENSMUST00000068135.2 ENSMUST00000068135.3 ENSMUST00000068135.4 ENSMUST00000068135.5 ENSMUST00000068135.6 ENSMUST00000068135.7 ENSMUST00000068135.8 ENSMUST00000068135.9 F8VQ15 F8VQ15_MOUSE NM_013906 uc009ora.1 uc009ora.2 uc009ora.3 uc009ora.4 This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is expressed in mouse lung, heart and macrophage-rich areas of atherosclerotic plaques. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. This gene is located adjacent to a related ADAMTS gene on chromosome 9. [provided by RefSeq, May 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF175282.1, SRR1660819.107997.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix Lacks conserved residue(s) required for the propagation of feature annotation. metalloendopeptidase activity proteolysis metallopeptidase activity zinc ion binding uc009ora.1 uc009ora.2 uc009ora.3 uc009ora.4 
ENSMUST00000068140.6 Tmem158 ENSMUST00000068140.6 transmembrane protein 158 (from RefSeq NM_001002267.2) B2RTM1 B2RTM1_MOUSE ENSMUST00000068140.1 ENSMUST00000068140.2 ENSMUST00000068140.3 ENSMUST00000068140.4 ENSMUST00000068140.5 NM_001002267 Tmem158 uc009sgb.1 uc009sgb.2 uc009sgb.3 membrane integral component of membrane peptide binding uc009sgb.1 uc009sgb.2 uc009sgb.3 
ENSMUST00000068156.8 Vps13a ENSMUST00000068156.8 vacuolar protein sorting 13A (from RefSeq NM_173028.4) Chac ENSMUST00000068156.1 ENSMUST00000068156.2 ENSMUST00000068156.3 ENSMUST00000068156.4 ENSMUST00000068156.5 ENSMUST00000068156.6 ENSMUST00000068156.7 Kiaa0986 NM_173028 Q3UQG7 Q3UX03 Q5DU08 Q5H8C4 Q80YV7 Q8C722 VP13A_MOUSE Vps13a uc008gwv.1 uc008gwv.2 uc008gwv.3 uc008gwv.4 Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria (By similarity). Negatively regulates lipid droplet size and motility (By similarity). Required for efficient lysosomal protein degradation (By similarity). Interacts (via FFAT motif) with VAPA and VAPB (By similarity). Interacts with RAB7A (By similarity). Interacts with XK (By similarity). Mitochondrion outer membrane ; Peripheral membrane protein Endoplasmic reticulum membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Lysosome membrane ; Peripheral membrane protein Lipid droplet Golgi apparatus Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle Note=Localizes at mitochondria-endosomes and mitochondria-endoplasmic reticulum contact sites. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q5H8C4-1; Sequence=Displayed; Name=2 ; IsoId=Q5H8C4-2; Sequence=VSP_052241, VSP_052242; The FFAT motif is required for interaction with VAPA and VAPB and its localization to the endoplasmic reticulum. The C-terminal part (3050-3166) is involved in phospholipid binding, including phosphatidylinositol 4,5-bisphosphate. Mice show defects in motor coordination, social investigation, erythrocyte morphology as well as size and morphology of the striatum. Provides a mouse model for chorea-acanthocytosis (CHAC) with a mild phenotype and late adult onset. Belongs to the VPS13 family. Sequence=BAE22761.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; molecular_function protein targeting to vacuole autophagy nervous system development locomotory behavior protein transport extrinsic component of membrane dense core granule social behavior protein retention in Golgi apparatus uc008gwv.1 uc008gwv.2 uc008gwv.3 uc008gwv.4 
ENSMUST00000068168.10 Kansl1l ENSMUST00000068168.10 KAT8 regulatory NSL complex subunit 1-like, transcript variant 2 (from RefSeq NM_177645.4) B2KGC3 E9QLD1 ENSMUST00000068168.1 ENSMUST00000068168.2 ENSMUST00000068168.3 ENSMUST00000068168.4 ENSMUST00000068168.5 ENSMUST00000068168.6 ENSMUST00000068168.7 ENSMUST00000068168.8 ENSMUST00000068168.9 KAL1L_MOUSE Kiaa4189 NM_177645 Q3TC00 Q5DTI6 Q8BNM1 Q8C4R5 uc007bin.1 uc007bin.2 uc007bin.3 uc007bin.4 Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q5DTI6-1; Sequence=Displayed; Name=2; IsoId=Q5DTI6-2; Sequence=VSP_031505, VSP_031506; Name=3; IsoId=Q5DTI6-3; Sequence=VSP_031507; Name=4; IsoId=Q5DTI6-4; Sequence=VSP_031502, VSP_031503; Name=5; IsoId=Q5DTI6-5; Sequence=VSP_031504; Acetylated on lysine residues by KAT8 upon ionizing radiation- induced DNA damage; deacetylated by HDAC3. Sequence=BAC38675.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD90312.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; histone acetyltransferase complex biological_process histone acetyltransferase binding histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation NSL complex histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) histone acetyltransferase activity (H4-K16 specific) uc007bin.1 uc007bin.2 uc007bin.3 uc007bin.4 
ENSMUST00000068182.3 Stfa3 ENSMUST00000068182.3 stefin A3 (from RefSeq NM_025288.2) CYT3_MOUSE ENSMUST00000068182.1 ENSMUST00000068182.2 NM_025288 P35173 Q540I0 Stf-3 Stf3 uc007zco.1 uc007zco.2 This is an intracellular thiol proteinase inhibitor. Cytoplasm Belongs to the cystatin family. endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity cytoplasm cytosol biological_process negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc007zco.1 uc007zco.2 
ENSMUST00000068214.11 Astn2 ENSMUST00000068214.11 astrotactin 2, transcript variant 2 (from RefSeq NM_207109.2) ASTN2_MOUSE E9Q8T4 ENSMUST00000068214.1 ENSMUST00000068214.10 ENSMUST00000068214.2 ENSMUST00000068214.3 ENSMUST00000068214.4 ENSMUST00000068214.5 ENSMUST00000068214.6 ENSMUST00000068214.7 ENSMUST00000068214.8 ENSMUST00000068214.9 Kiaa0634 NM_207109 Q6A031 Q80Z10 Q811X9 Q811Y0 Q811Y1 Q811Y2 uc008thn.1 uc008thn.2 uc008thn.3 Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (PubMed:20573900). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (By similarity). Interacts with ASTN1; the interaction is not calcium- dependent. Membrane ; Multi- pass membrane protein Perikaryon Cytoplasm, cell cortex Early endosome Late endosome Cytoplasmic vesicle, clathrin-coated vesicle Cytoplasmic vesicle Note=Integral membrane protein not detected at the cell membrane. Detected in cytoplasmic vesicles in the cell cortex, close to the anterior pole of migrating neurons. Detected at the base of the leading process in migrating neurons. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80Z10-1; Sequence=Displayed; Name=2; IsoId=Q80Z10-2; Sequence=VSP_028938; Name=3; Synonyms=a ; IsoId=Q80Z10-3; Sequence=VSP_058454; Detected in cerebellum granule neurons; not detected in astroglia (at protein level). Detected primarily in cerebellum, and at lower levels in brain cortex, olfactory bulb, hindbrain and hippocampus dentate gyrus. Between 6 and 10 days after birth, when granule cell migration occurs in the cerebellum, detected in granule cell precursors in the external germinal layer, the molecular layer, the internal granule layer and in Purkinje neurons. Detected in postmitotic neurons in adult cerebellum. Detected at low levels in embryonic brain. Highly expressed 6 and 10 days after birth, when granule cell migration occurs in the cerebellum; expression in cerebellum is considerably higher than in brain cortex. Expressed at lower levels in adult cerebellum. The C-terminal region after the fibronectin type-III domain presents structural similarity to annexin domains and binds calcium ions. Belongs to the astrotactin family. Sequence=BAD32265.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; calcium ion binding protein binding cytoplasm endosome early endosome late endosome cell cortex protein transport membrane integral component of membrane clathrin-coated vesicle cytoplasmic vesicle perikaryon inositol 1,3,4,5 tetrakisphosphate binding metal ion binding establishment of body hair planar orientation cell pole negative regulation of protein localization to cell surface uc008thn.1 uc008thn.2 uc008thn.3 
ENSMUST00000068225.15 Nusap1 ENSMUST00000068225.15 nucleolar and spindle associated protein 1, transcript variant 1 (from RefSeq NM_133851.4) ENSMUST00000068225.1 ENSMUST00000068225.10 ENSMUST00000068225.11 ENSMUST00000068225.12 ENSMUST00000068225.13 ENSMUST00000068225.14 ENSMUST00000068225.2 ENSMUST00000068225.3 ENSMUST00000068225.4 ENSMUST00000068225.5 ENSMUST00000068225.6 ENSMUST00000068225.7 ENSMUST00000068225.8 ENSMUST00000068225.9 NM_133851 NUSAP_MOUSE Q8C2L8 Q8C989 Q921Z0 Q9ERH4 uc008lua.1 uc008lua.2 Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. Interacts with DNA and microtubules. Microtubule bundling is inhibited by IPO7, KPNA2 and KPNB1 while association with DNA is also inhibited by IPO7 and KPNA2. Cytoplasm. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Chromosome. Note=Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase. Localizes to the mitotic spindle and to the chromosomes during anaphase and telophase then disappears from around the chromosomes during cytokinesis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ERH4-1; Sequence=Displayed; Name=2; IsoId=Q9ERH4-2; Sequence=VSP_027913; Expression peaks at G2/M phase and is low in G1 phase. Expressed at higher levels in immature erythroblasts relative to mature erythroblasts. The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination. Ubiquitinated. Ubiquitination by FZR1 may lead to proteasome- dependent degradation of this protein (By similarity). Belongs to the NUSAP family. mitotic sister chromatid segregation microtubule cytoskeleton organization mitotic cytokinesis DNA binding nucleus chromosome nucleolus cytoplasm spindle cytoskeleton microtubule cell cycle mitotic chromosome condensation microtubule binding establishment of mitotic spindle localization positive regulation of mitotic nuclear division cell division mitotic spindle spindle microtubule uc008lua.1 uc008lua.2 
ENSMUST00000068233.11 Kcnmb4 ENSMUST00000068233.11 potassium large conductance calcium-activated channel, subfamily M, beta member 4, transcript variant 4 (from RefSeq NR_184586.1) ENSMUST00000068233.1 ENSMUST00000068233.10 ENSMUST00000068233.2 ENSMUST00000068233.3 ENSMUST00000068233.4 ENSMUST00000068233.5 ENSMUST00000068233.6 ENSMUST00000068233.7 ENSMUST00000068233.8 ENSMUST00000068233.9 KCMB4_MOUSE NR_184586 Q149I1 Q9JIN6 uc007hbw.1 uc007hbw.2 uc007hbw.3 Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations (By similarity). Interacts with KCNMA1 tetramer (PubMed:10804197). There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer (PubMed:10804197). Interacts with FMR1 (via N-terminus) (PubMed:25561520). Membrane ; Multi-pass membrane protein Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain. Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics (By similarity). N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin (By similarity). Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily. action potential potassium channel activity detection of calcium ion protein binding integral component of plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex calcium-activated potassium channel activity potassium channel regulator activity membrane integral component of membrane neuronal action potential potassium ion transmembrane transport uc007hbw.1 uc007hbw.2 uc007hbw.3 
ENSMUST00000068235.6 Nkapl ENSMUST00000068235.6 NFKB activating protein-like (from RefSeq NM_025719.3) ENSMUST00000068235.1 ENSMUST00000068235.2 ENSMUST00000068235.3 ENSMUST00000068235.4 ENSMUST00000068235.5 NKAPL_MOUSE NM_025719 Nkapl Q3TV39 Q4KKZ9 Q5EBJ1 Q5SZT7 Q6P8T3 Q9CUJ2 Q9D5Y8 uc007pqm.1 uc007pqm.2 uc007pqm.3 uc007pqm.4 Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis. Interacts with RBPJ, CIR1 and HDAC3. Nucleus Specific to testis (at protein level). Detected in differenting spermatogonia and early spermatocytes (at protein level). Strongly expressed in testis from 3 weeks onwards. Viable. Males are infertile with reduced testis size, while female fertility is not affected. In the testis, germ cell development arrests at the pachytene spermatocyte stage leading to complete absence of mature spermatozoa. Belongs to the NKAP family. Sequence=AAH61080.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; molecular_function chromatin binding cellular_component nucleus Notch signaling pathway spermatogenesis biological_process cell differentiation negative regulation of transcription, DNA-templated uc007pqm.1 uc007pqm.2 uc007pqm.3 uc007pqm.4 
ENSMUST00000068237.12 Mlxip ENSMUST00000068237.12 MLX interacting protein, transcript variant 2 (from RefSeq NM_133917.3) ENSMUST00000068237.1 ENSMUST00000068237.10 ENSMUST00000068237.11 ENSMUST00000068237.2 ENSMUST00000068237.3 ENSMUST00000068237.4 ENSMUST00000068237.5 ENSMUST00000068237.6 ENSMUST00000068237.7 ENSMUST00000068237.8 ENSMUST00000068237.9 G5E8D8 G5E8D8_MOUSE Mlxip NM_133917 uc008znr.1 uc008znr.2 uc008znr.3 uc008znr.4 uc008znr.5 uc008znr.6 RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter uc008znr.1 uc008znr.2 uc008znr.3 uc008znr.4 uc008znr.5 uc008znr.6 
ENSMUST00000068242.9 Rimklb ENSMUST00000068242.9 ribosomal modification protein rimK-like family member B (from RefSeq NM_027664.1) ENSMUST00000068242.1 ENSMUST00000068242.2 ENSMUST00000068242.3 ENSMUST00000068242.4 ENSMUST00000068242.5 ENSMUST00000068242.6 ENSMUST00000068242.7 ENSMUST00000068242.8 Fam80b Kiaa1238 NM_027664 Q69ZN3 Q80WS1 Q8CA77 Q9D3Z1 RIMKB_MOUSE uc009dpg.1 uc009dpg.2 uc009dpg.3 Catalyzes the synthesis of beta-citryl-L-glutamate and N- acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate. Reaction=ATP + citrate + L-glutamate = ADP + beta-citrylglutamate + H(+) + phosphate; Xref=Rhea:RHEA:40043, ChEBI:CHEBI:15378, ChEBI:CHEBI:16947, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:76942, ChEBI:CHEBI:456216; EC=6.3.1.17; Evidence= Reaction=ATP + L-glutamate + N-acetyl-L-aspartate = ADP + H(+) + N- acetyl-L-aspartyl-L-glutamate + phosphate; Xref=Rhea:RHEA:40035, ChEBI:CHEBI:15378, ChEBI:CHEBI:16953, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:76931, ChEBI:CHEBI:456216; EC=6.3.2.41; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit. ; Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80WS1-1; Sequence=Displayed; Name=2; IsoId=Q80WS1-2; Sequence=VSP_024200, VSP_024201; Name=3; IsoId=Q80WS1-3; Sequence=VSP_024200, VSP_024201, VSP_024202, VSP_024203; Strongly expressed in brain and testis. Expressed in eyes, thymus, lung, kidney, skeletal muscle, spleen, skin and heart. Expressed in neurons of the neocortex, the gray matter and Purkinje cells. N-acetyl-L-aspartyl-L-glutamate (NAAG) is the most abundant dipeptide present in vertebrate central nervous system (CNS). Beta-citryl-L-glutamate, a structural analog of NAAG, is present in testis and immature brain. Belongs to the RimK family. Sequence=BAD32413.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding ATP binding cytoplasm cellular protein modification process ligase activity metal ion binding N-acetyl-L-aspartate-L-glutamate ligase activity citrate-L-glutamate ligase activity uc009dpg.1 uc009dpg.2 uc009dpg.3 
ENSMUST00000068258.3 9130008F23Rik ENSMUST00000068258.3 RIKEN cDNA 9130008F23 gene (from RefSeq NM_027834.3) 9130008F23Rik ENSMUST00000068258.1 ENSMUST00000068258.2 NM_027834 Q9D2Z6 Q9D2Z6_MOUSE uc008com.1 uc008com.2 uc008com.3 blastocyst hatching molecular_function cellular_component uc008com.1 uc008com.2 uc008com.3 
ENSMUST00000068259.10 Klhdc10 ENSMUST00000068259.10 kelch domain containing 10, transcript variant 1 (from RefSeq NM_029742.3) ENSMUST00000068259.1 ENSMUST00000068259.2 ENSMUST00000068259.3 ENSMUST00000068259.4 ENSMUST00000068259.5 ENSMUST00000068259.6 ENSMUST00000068259.7 ENSMUST00000068259.8 ENSMUST00000068259.9 KLD10_MOUSE Kiaa0265 Klhdc10 NM_029742 Q6A095 Q6PAR0 Q8BH94 Q8BPK7 Q8C3Q4 Q8C7G4 Q9CWF4 uc009bfe.1 uc009bfe.2 uc009bfe.3 uc009bfe.4 Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) or an alanine tail (CAT tail) at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(KLHDC10) complex is involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: CRL2(KLHDC10) acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (By similarity). Participates in the oxidative stress-induced cell death through MAP3K5 activation (By similarity). Inhibits PPP5C phosphatase activity on MAP3K5 (PubMed:23102700). Acts as a regulator of necroptosis (PubMed:27631783). Protein modification; protein ubiquitination. Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter KLHDC10 (By similarity). Interacts (via the 6 Kelch repeats) with PPP5C (PubMed:23102700). Nucleus Cytoplasm [Isoform 2]: Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PAR0-1; Sequence=Displayed; Name=2; IsoId=Q6PAR0-2; Sequence=VSP_031486; Name=3; IsoId=Q6PAR0-3; Sequence=VSP_031485; No visible phenotype in normal conditions (PubMed:27631783). Mice are protected against TNF-alpha-induced systemic inflammation: they show a reduction in the inflammatory response, but not in early systemic necroptosis (PubMed:27631783). Belongs to the KLHDC10 family. Sequence=BAB27179.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC35547.1; Type=Frameshift; Evidence=; Sequence=BAD32201.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function nucleus nucleoplasm cytoplasm positive regulation of stress-activated MAPK cascade uc009bfe.1 uc009bfe.2 uc009bfe.3 uc009bfe.4 
ENSMUST00000068261.9 Atp6v1g2 ENSMUST00000068261.9 ATPase, H+ transporting, lysosomal V1 subunit G2, transcript variant 1 (from RefSeq NM_023179.3) Atp6g2 ENSMUST00000068261.1 ENSMUST00000068261.2 ENSMUST00000068261.3 ENSMUST00000068261.4 ENSMUST00000068261.5 ENSMUST00000068261.6 ENSMUST00000068261.7 ENSMUST00000068261.8 NM_023179 Ng38 Q9WTT4 VATG2_MOUSE uc057kxp.1 uc057kxp.2 uc057kxp.3 Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Melanosome Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein Note=Highly enriched in late-stage melanosomes. Belongs to the V-ATPase G subunit family. protein binding ion transport hydrogen-exporting ATPase activity, phosphorylative mechanism vacuolar proton-transporting V-type ATPase complex ATPase activity integral component of synaptic vesicle membrane melanosome ATPase activity, coupled to transmembrane movement of substances hydrogen ion transmembrane transport uc057kxp.1 uc057kxp.2 uc057kxp.3 
ENSMUST00000068262.6 Nt5c1a ENSMUST00000068262.6 5'-nucleotidase, cytosolic IA (from RefSeq NM_001085502.2) 5NT1A_MOUSE A3KFX0 B2RVQ9 ENSMUST00000068262.1 ENSMUST00000068262.2 ENSMUST00000068262.3 ENSMUST00000068262.4 ENSMUST00000068262.5 NM_001085502 uc008uoy.1 uc008uoy.2 uc008uoy.3 Catalyzes the hydrolysis of ribonucleotide and deoxyribonucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (By similarity). AMP is the major substrate but can also hydrolyze dCMP and IMP (By similarity). Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377, ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5; Evidence=; Reaction=a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'- deoxyribonucleoside + phosphate; Xref=Rhea:RHEA:36167, ChEBI:CHEBI:15377, ChEBI:CHEBI:18274, ChEBI:CHEBI:43474, ChEBI:CHEBI:65317; EC=3.1.3.89; Evidence=; Reaction=H2O + IMP = inosine + phosphate; Xref=Rhea:RHEA:27718, ChEBI:CHEBI:15377, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474, ChEBI:CHEBI:58053; EC=3.1.3.99; Evidence=; Reaction=AMP + H2O = adenosine + phosphate; Xref=Rhea:RHEA:29375, ChEBI:CHEBI:15377, ChEBI:CHEBI:16335, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; Evidence=; Reaction=dCMP + H2O = 2'-deoxycytidine + phosphate; Xref=Rhea:RHEA:29363, ChEBI:CHEBI:15377, ChEBI:CHEBI:15698, ChEBI:CHEBI:43474, ChEBI:CHEBI:57566; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by ADP. Cytoplasm Belongs to the 5'-nucleotidase type 3 family. nucleotide binding magnesium ion binding cytoplasm cytosol 5'-nucleotidase activity nucleotide metabolic process purine nucleoside monophosphate catabolic process dephosphorylation hydrolase activity adenosine metabolic process uc008uoy.1 uc008uoy.2 uc008uoy.3 
ENSMUST00000068282.7 Atl2 ENSMUST00000068282.7 atlastin GTPase 2, transcript variant 1 (from RefSeq NM_019717.3) ATLA2_MOUSE Arl6ip2 ENSMUST00000068282.1 ENSMUST00000068282.2 ENSMUST00000068282.3 ENSMUST00000068282.4 ENSMUST00000068282.5 ENSMUST00000068282.6 NM_019717 Q3UX01 Q6PA06 Q7TMM3 uc008dqe.1 uc008dqe.2 uc008dqe.3 GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. Interacts with REEP5 and RTN3 (PubMed:19665976). Interacts with ZFYVE27 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Localizes at endoplasmic reticulum (ER) three-way tubular junctions. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PA06-1; Sequence=Displayed; Name=2; IsoId=Q6PA06-2; Sequence=VSP_025311; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily. nucleotide binding GTPase activity protein binding GTP binding endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum organization Golgi organization membrane integral component of membrane hydrolase activity identical protein binding protein homooligomerization endoplasmic reticulum tubular network membrane endoplasmic reticulum tubular network membrane organization uc008dqe.1 uc008dqe.2 uc008dqe.3 
ENSMUST00000068293.4 Smco3 ENSMUST00000068293.4 single-pass membrane protein with coiled-coil domains 3 (from RefSeq NM_001039558.2) ENSMUST00000068293.1 ENSMUST00000068293.2 ENSMUST00000068293.3 NM_001039558 Q8BNZ4 Q8BQM7 Q8BR60 SMCO3_MOUSE uc009emj.1 uc009emj.2 uc009emj.3 Membrane ; Single-pass membrane protein Sequence=BAC37368.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc009emj.1 uc009emj.2 uc009emj.3 
ENSMUST00000068301.11 Cept1 ENSMUST00000068301.11 choline/ethanolaminephosphotransferase 1, transcript variant 1 (from RefSeq NM_133869.4) CEPT1_MOUSE Cept1 ENSMUST00000068301.1 ENSMUST00000068301.10 ENSMUST00000068301.2 ENSMUST00000068301.3 ENSMUST00000068301.4 ENSMUST00000068301.5 ENSMUST00000068301.6 ENSMUST00000068301.7 ENSMUST00000068301.8 ENSMUST00000068301.9 NM_133869 Q8BGS7 Q8VC64 uc008qwc.1 uc008qwc.2 uc008qwc.3 Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. Reaction=a 1,2-diacyl-sn-glycerol + CDP-ethanolamine = a 1,2-diacyl-sn- glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:32943, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:64612; EC=2.7.8.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32944; Evidence=; Reaction=a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn- glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:32939, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57643, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377; EC=2.7.8.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32940; Evidence=; Reaction=1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acyl- sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:36179, ChEBI:CHEBI:15378, ChEBI:CHEBI:36702, ChEBI:CHEBI:52595, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377; EC=2.7.8.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36180; Evidence=; Reaction=1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline = 1-O-(1Z- alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:36227, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:77286, ChEBI:CHEBI:77296; EC=2.7.8.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36228; Evidence=; Reaction=1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn- glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54232, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:76979, ChEBI:CHEBI:78228; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54233; Evidence=; Reaction=1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn- glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54236, ChEBI:CHEBI:15378, ChEBI:CHEBI:18155, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:78226; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54237; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di- (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54240, ChEBI:CHEBI:15378, ChEBI:CHEBI:52333, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:74669; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54241; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54244, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:73001, ChEBI:CHEBI:75466; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54245; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2- di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:54248, ChEBI:CHEBI:15378, ChEBI:CHEBI:52333, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:74986; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54249; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP- ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:54252, ChEBI:CHEBI:15378, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:73007, ChEBI:CHEBI:75466; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54253; Evidence=; Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z- docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54332, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:74963, ChEBI:CHEBI:82949; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54333; Evidence=; Reaction=1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di- (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54336, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:83717, ChEBI:CHEBI:84417; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54337; Evidence=; Reaction=1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2- di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:54340, ChEBI:CHEBI:15378, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:84417, ChEBI:CHEBI:138145; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54341; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O- hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54348, ChEBI:CHEBI:15378, ChEBI:CHEBI:44811, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:75936; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54349; Evidence=; Reaction=1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54352, ChEBI:CHEBI:15378, ChEBI:CHEBI:55430, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:77184; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54353; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3. Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2. Endoplasmic reticulum membrane ; Multi-pass membrane protein Nucleus membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGS7-1; Sequence=Displayed; Name=2; IsoId=Q8BGS7-2; Sequence=VSP_025988; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. diacylglycerol cholinephosphotransferase activity ethanolaminephosphotransferase activity nucleus endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus lipid metabolic process phosphatidylethanolamine biosynthetic process phosphatidylcholine biosynthetic process CDP-choline pathway phospholipid biosynthetic process membrane integral component of membrane transferase activity phosphotransferase activity, for other substituted phosphate groups nuclear membrane metal ion binding uc008qwc.1 uc008qwc.2 uc008qwc.3 
ENSMUST00000068302.4 Tas2r117 ENSMUST00000068302.4 taste receptor, type 2, member 117 (from RefSeq NM_207021.1) A2RSQ6 ENSMUST00000068302.1 ENSMUST00000068302.2 ENSMUST00000068302.3 NM_207021 Q7M715 T2r54 TR117_MOUSE Tas2r117 uc009ejp.1 uc009ejp.2 uc009ejp.3 Putative taste receptor which may play a role in the perception of bitterness. Membrane ; Multi-pass membrane protein Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009ejp.1 uc009ejp.2 uc009ejp.3 
ENSMUST00000068307.4 Kbtbd13 ENSMUST00000068307.4 kelch repeat and BTB (POZ) domain containing 13 (from RefSeq NM_028974.2) ENSMUST00000068307.1 ENSMUST00000068307.2 ENSMUST00000068307.3 KBTBD_MOUSE NM_028974 Q8C828 uc009qde.1 uc009qde.2 uc009qde.3 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. Protein modification; protein ubiquitination. Component of the BCR(KBTBD13) E3 ubiquitin ligase complex, at least composed of CUL3 and KBTBD13 and RBX1. Interacts with CUL3 (By similarity). Cytoplasm Expressed in skeletal muscle, heart and lung. The BCB domain mediates the interaction with CUL3. Autoubiquitinated. Sequence=BAC33390.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cytoplasm protein ubiquitination uc009qde.1 uc009qde.2 uc009qde.3 
ENSMUST00000068316.8 Agtr1b ENSMUST00000068316.8 angiotensin II receptor, type 1b (from RefSeq NM_175086.3) AGTRB_MOUSE ENSMUST00000068316.1 ENSMUST00000068316.2 ENSMUST00000068316.3 ENSMUST00000068316.4 ENSMUST00000068316.5 ENSMUST00000068316.6 ENSMUST00000068316.7 NM_175086 P29755 uc008osr.1 uc008osr.2 Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. Interacts with MAS1 (By similarity). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity). Cell membrane ; Multi-pass membrane protein C-terminal Ser or Thr residues may be phosphorylated. Belongs to the G-protein coupled receptor 1 family. blood vessel development angiotensin type I receptor activity response to hypoxia kidney development regulation of systemic arterial blood pressure by circulatory renin-angiotensin G-protein coupled receptor activity angiotensin type II receptor activity plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration response to nutrient response to salt stress membrane integral component of membrane regulation of vasoconstriction response to nicotine response to immobilization stress angiotensin-activated signaling pathway response to drug drinking behavior response to estrogen positive regulation of blood pressure cellular response to dexamethasone stimulus phospholipase C-activating angiotensin-activated signaling pathway positive regulation of branching involved in ureteric bud morphogenesis response to angiotensin uc008osr.1 uc008osr.2 
ENSMUST00000068317.13 Cyp3a25 ENSMUST00000068317.13 cytochrome P450, family 3, subfamily a, polypeptide 25, transcript variant 1 (from RefSeq NM_019792.2) CP3AP_MOUSE ENSMUST00000068317.1 ENSMUST00000068317.10 ENSMUST00000068317.11 ENSMUST00000068317.12 ENSMUST00000068317.2 ENSMUST00000068317.3 ENSMUST00000068317.4 ENSMUST00000068317.5 ENSMUST00000068317.6 ENSMUST00000068317.7 ENSMUST00000068317.8 ENSMUST00000068317.9 NM_019792 O09158 uc009amz.1 uc009amz.2 uc009amz.3 uc009amz.4 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane steroid metabolic process testosterone 16-alpha-hydroxylase activity steroid hydroxylase activity response to bacterium membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding organelle membrane intracellular membrane-bounded organelle metal ion binding testosterone 6-beta-hydroxylase activity oxidation-reduction process aromatase activity oxidative demethylation uc009amz.1 uc009amz.2 uc009amz.3 uc009amz.4 
ENSMUST00000068322.7 Sec14l3 ENSMUST00000068322.7 SEC14-like lipid binding 3 (from RefSeq NM_001029937.2) ENSMUST00000068322.1 ENSMUST00000068322.2 ENSMUST00000068322.3 ENSMUST00000068322.4 ENSMUST00000068322.5 ENSMUST00000068322.6 NM_001029937 Q5SQ27 Q5SQ27_MOUSE Sec14l3 uc007huf.1 uc007huf.2 uc007huf.3 uc007huf.4 molecular_function biological_process uc007huf.1 uc007huf.2 uc007huf.3 uc007huf.4 
ENSMUST00000068326.14 Slc8b1 ENSMUST00000068326.14 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1, transcript variant 1 (from RefSeq NM_133221.2) ENSMUST00000068326.1 ENSMUST00000068326.10 ENSMUST00000068326.11 ENSMUST00000068326.12 ENSMUST00000068326.13 ENSMUST00000068326.2 ENSMUST00000068326.3 ENSMUST00000068326.4 ENSMUST00000068326.5 ENSMUST00000068326.6 ENSMUST00000068326.7 ENSMUST00000068326.8 ENSMUST00000068326.9 NCLX_MOUSE NM_133221 Nckx6 Nclx Q3U067 Q80XM7 Q925Q3 Slc24a6 Slc8b1 uc008zhj.1 uc008zhj.2 uc008zhj.3 uc008zhj.4 Mitochondrial sodium/calcium antiporter that mediates sodium- dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:28445457). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (PubMed:24067497, PubMed:28445457). Regulates rates of glucose- dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (By similarity). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (By similarity). Involved in B-lymphocyte chemotaxis (PubMed:27328625). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (By similarity). In contrast to other members of the family its function is independent of K(+) (By similarity). Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in); Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108; Evidence=; Reaction=Ca(2+)(in) + 3 Li(+)(out) = Ca(2+)(out) + 3 Li(+)(in); Xref=Rhea:RHEA:72631, ChEBI:CHEBI:29108, ChEBI:CHEBI:49713; Evidence=; Inhibited by the sodium/calcium exchanger inhibitor CGP-37157 (PubMed:28445457). Strongly inhibited by zinc (By similarity). Mitochondrion inner membrane ; Multi-pass membrane protein Note=Mainly localizes to mitochondrion inner membrane (PubMed:20018762). [Isoform 2]: Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=L , Long ; IsoId=Q925Q3-1; Sequence=Displayed; Name=2; Synonyms=S , Short ; IsoId=Q925Q3-2; Sequence=VSP_016998; Name=3; IsoId=Q925Q3-3; Sequence=VSP_016997; Ubiquitously expressed. Expressed in dental tissues. Phosphorylation at Ser-258 by PKA prevents calcium overload. Conditional deletion in adult hearts causes sudden death in 87% of the mice. Hearts show substantial cardiac remodeling, including an increase in heart mass and correlative change in cardiomyocyte cross-sectional area, as well as a significant increase in cardiac fibrosis. Defects are probably due to mitochondrial calcium overload leading to increased generation of superoxide and necrotic cell death. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. Isoform 1 was reported to not have cation exchanger activity (PubMed:12080145). However, such result is unclear. Isoform 1 and isoform 2 were reported to localize to the endoplasmic reticulum membrane and cell membrane, respectively (PubMed:14625281). This result is however not supported by other studies that report localization to the mitochondrial membrane (PubMed:20018762, PubMed:24067497). calcium:sodium antiporter activity mitochondrion mitochondrial inner membrane plasma membrane ion transport sodium ion transport calcium ion transport mitochondrial calcium ion transport antiporter activity membrane integral component of membrane mitochondrial crista integral component of mitochondrial membrane sodium ion transmembrane transport sarcolemma glucose homeostasis identical protein binding protein homodimerization activity regulation of insulin secretion response to stimulus regulation of cytosolic calcium ion concentration mitochondrial calcium ion homeostasis transmembrane transport calcium ion transmembrane transport regulation of cardiac muscle cell membrane potential calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential mitochondrial calcium release regulation of lymphocyte chemotaxis regulation of store-operated calcium entry uc008zhj.1 uc008zhj.2 uc008zhj.3 uc008zhj.4 
ENSMUST00000068340.3 Pramel3e ENSMUST00000068340.3 PRAME like 3E (from RefSeq NM_177918.2) A2AWL3 AV320801 ENSMUST00000068340.1 ENSMUST00000068340.2 NM_177918 Pramel3e Q8C0S8 Q8C0S8_MOUSE uc009uhf.1 uc009uhf.2 molecular_function cytoplasm biological_process uc009uhf.1 uc009uhf.2 
ENSMUST00000068351.14 Lrtm2 ENSMUST00000068351.14 Membrane ; Single-pass type I membrane protein (from UniProt Q8BGX3) BC058944 ENSMUST00000068351.1 ENSMUST00000068351.10 ENSMUST00000068351.11 ENSMUST00000068351.12 ENSMUST00000068351.13 ENSMUST00000068351.2 ENSMUST00000068351.3 ENSMUST00000068351.4 ENSMUST00000068351.5 ENSMUST00000068351.6 ENSMUST00000068351.7 ENSMUST00000068351.8 ENSMUST00000068351.9 LRTM2_MOUSE Q8BGX3 uc009dmb.1 uc009dmb.2 uc009dmb.3 Membrane ; Single-pass type I membrane protein axon guidance heparin binding membrane integral component of membrane Roundabout binding negative chemotaxis positive regulation of synapse assembly uc009dmb.1 uc009dmb.2 uc009dmb.3 
ENSMUST00000068355.8 Opn5 ENSMUST00000068355.8 opsin 5 (from RefSeq NM_181753.4) ENSMUST00000068355.1 ENSMUST00000068355.2 ENSMUST00000068355.3 ENSMUST00000068355.4 ENSMUST00000068355.5 ENSMUST00000068355.6 ENSMUST00000068355.7 Gpr136 NM_181753 OPN5_MOUSE Pgr12 Q059L5 Q6VZZ7 Q7TQP1 Q80T51 Q8BYI2 uc008coq.1 uc008coq.2 uc008coq.3 G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina (PubMed:22043319). Preferentially binds the chromophore 11- cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light) (PubMed:22043319, PubMed:31607531). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light- response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (PubMed:30936473). Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (PubMed:26392540, PubMed:30240620). Acts as a circadian photoreceptor in the outer ear and vibrissal pads, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (PubMed:31607531). Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (PubMed:30936473). Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (PubMed:30936473). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6VZZ7-1; Sequence=Displayed; Name=2; IsoId=Q6VZZ7-2; Sequence=VSP_014041, VSP_014042; Expressed in the brain (at protein level) (PubMed:14623103, PubMed:22043319). Weakly expressed in the skin and liver (at protein level) (PubMed:22043319). Abundantly expressed in striated muscle cells (PubMed:22043319). Expressed in Math7/Atok7- dependent retinal ganglion cells in the ganglion cell layer (at protein level) (PubMed:14623103, PubMed:22043319, PubMed:26392540, PubMed:30240620, PubMed:31607531). Additionally expressed in horizontal and amacrine cells in the inner nuclear layer of the retina (at protein level) (PubMed:22043319). Expressed around the base of hair follicles and in epidermal and sebaceous gland cells of the outer ear (at protein level) (PubMed:22043319, PubMed:31607531). Abundantly expressed in vibrissae hair follicles and weakly expressed in the vibrissae skin pad, dorsal back skin, and tail (PubMed:31607531). Expressed weakly in the inner retina at postnatal day 5 (P5), with expression becoming abundant in retinal ganglion cells at P8 (PubMed:30936473). Expressed throughout the retinal sublaminae layers, with abundant expression in the ganglion cell layer and nerve fiber layer at P12 (PubMed:30936473). Expressed in ganglion cells in the optic tracts, superior colliculus and lateral geniculate nucleus of the brain at P28 (PubMed:30936473). Expressed around the base of hair follicles in the dorsal ear skin, in the vibrissal nose pad, and weakly expressed below the epidermis in the vibrissal nose pad at P8 (PubMed:31607531). It is uncertain whether Cys-315 or Cys-316 is palmitoylated. Ultrastructure of the retina is normal (PubMed:30936473, PubMed:30240620, PubMed:26392540). Newborn mice show normal hyaloid vessel numbers and normal vessel cellularity (PubMed:30936473). Retinas show normal expression patterns of rod and cone opsins including Opn4 (PubMed:26392540, PubMed:30240620). Decreased activated Vegfr2 in the hyaloid vessels and increased activated Akt1 at P5 (PubMed:30936473). Reduced levels of dopamine in the retina, however increased levels in the vitreous at P6 (PubMed:30936473). Reduced number of hyaloid blood vessels due to precocious regression, however no change in abundance of Vegfa or Flt1 at P8 (PubMed:30936473). Expression of tyrosine hydroxylase Th in retinal cell processes at P8, with increased expression in developed dopaminergic amacrine cells at P15 (PubMed:30936473). Loss of retinal and corneal circadian rhythm photoentrainment (PubMed:26392540, PubMed:30240620). Reduced UVA-induced phase-shift response and Fos expression in the suprachiasmatic nuclei (SCN) in the brain (PubMed:30240620). Abolishes retinaldehyde-dependent photoentrainment in the dermal tissues of the outer ear and vibrissal pad (PubMed:31607531). Loss of phase shifting activity in response to violet light and expression of circadian clock-genes in the skin of the outer ear during light-to-dark cycle, including Per1, Per2, Cry2, Dbp and Nr1d2 (PubMed:31607531). Pde6b and Opn5 double knockout mice also show loss of retinal ultrastructures and a more severe reduction in the rate of circadian photoentrainment, light-induced phase-shift response and Fos expression in the SCN (PubMed:30240620). Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. photoreceptor outer segment G-protein coupled receptor activity 11-cis retinal binding integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway visual perception phototransduction G-protein coupled photoreceptor activity detection of visible light photoreceptor activity membrane integral component of membrane protein-chromophore linkage response to stimulus cellular response to light stimulus uc008coq.1 uc008coq.2 uc008coq.3 
ENSMUST00000068360.2 A830031A19Rik ENSMUST00000068360.2 A830031A19Rik (from geneSymbol) A830031A19Rik AK080628 ENSMUST00000068360.1 Q8BNT5 Q8BNT5_MOUSE uc287xao.1 uc287xao.2 molecular_function cellular_component biological_process uc287xao.1 uc287xao.2 
ENSMUST00000068387.11 Ep300 ENSMUST00000068387.11 E1A binding protein p300 (from RefSeq NM_177821.7) B2RWS6 E9PYJ8 ENSMUST00000068387.1 ENSMUST00000068387.10 ENSMUST00000068387.2 ENSMUST00000068387.3 ENSMUST00000068387.4 ENSMUST00000068387.5 ENSMUST00000068387.6 ENSMUST00000068387.7 ENSMUST00000068387.8 ENSMUST00000068387.9 EP300_MOUSE NM_177821 P300 uc007wws.1 uc007wws.2 uc007wws.3 Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (By similarity). Acetylates all four core histones in nucleosomes (By similarity). Histone acetylation gives an epigenetic tag for transcriptional activation (By similarity). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein (PubMed:18486321, PubMed:24216764). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity). Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (By similarity). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:28883095, PubMed:28576496). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (By similarity). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (By similarity). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53- dependent transcription and apoptosis (By similarity). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (By similarity). Acetylates HDAC1 leading to its inactivation and modulation of transcription (By similarity). Acetylates 'Lys-247' of EGR2 (PubMed:28576496). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (By similarity). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium (By similarity). Promotes cardiac myocyte enlargement (By similarity). Can also mediate transcriptional repression (By similarity). Acetylates FOXO1 and enhances its transcriptional activity (By similarity). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (By similarity). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (By similarity). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:14645221, PubMed:9512516). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (By similarity). Acetylates MEF2D (By similarity). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (PubMed:25200183). Acetylates PCK1 and promotes PCK1 anaplerotic activity (By similarity). Acetylates RXRA and RXRG (By similarity). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (By similarity). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (By similarity). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2- hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:27105113). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Histone crotonyltransferase activity is dependent on the concentration of (2E)- butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (By similarity). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:27105113). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (By similarity). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes. Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (By similarity). Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45949; Evidence=; Reaction=butanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-butanoyl- L-lysyl-[protein]; Xref=Rhea:RHEA:53912, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13708, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371, ChEBI:CHEBI:137955; Evidence=; Reaction=(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)- (2E)-butenoyl-L-lysyl-[protein]; Xref=Rhea:RHEA:53908, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:13707, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57332, ChEBI:CHEBI:137954; Evidence=; Reaction=L-lysyl-[protein] + propanoyl-CoA = CoA + H(+) + N(6)- propanoyl-L-lysyl-[protein]; Xref=Rhea:RHEA:54020, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:13758, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392, ChEBI:CHEBI:138019; Evidence=; Reaction=2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]; Xref=Rhea:RHEA:24180, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:15921, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:131780, ChEBI:CHEBI:144968; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24181; Evidence=; Reaction=L-lysyl-[protein] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L- lysyl-[protein]; Xref=Rhea:RHEA:61996, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:16001, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57382, ChEBI:CHEBI:145324; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61997; Evidence=; Part of a complex composed of MSX3, CREBBP/CBP AND EP300/p300; the interaction with MSX3 decreases histone acetylation activity (PubMed:11115394). Interacts with HIF1A; the interaction is stimulated in response to hypoxia and inhibited by CITED2. Probably part of a complex with HIF1A and CREBBP. Interacts (via N-terminus) with TFAP2A (via N-terminus); the interaction requires CITED2 (By similarity). Interacts (via CH1 domain) with CITED2 (via C-terminus) (PubMed:10593900). Interacts with CITED1 (unphosphorylated form preferentially and via C-terminus) (PubMed:10722728). Interacts with ESR1; the interaction is estrogen-dependent and enhanced by CITED1 (By similarity). Interacts with HIPK2 (PubMed:16917507). Interacts with DTX1, EID1, ELF3, FEN1, LEF1, NCOA1, NCOA6, NR3C1, PCAF, PELP1, PRDM6, SP1, SP3, SPIB, SRY, TCF7L2, DDX5, DDX17, SATB1, SRCAP and TRERF1 (By similarity). Interacts with JMY, the complex activates p53/TP53 transcriptional activity. Interacts with TTC5/STRAP; the interaction facilitates the association between JMY and p300/EP300 cofactors. Interacts with p53/TP53; the interaction is facilitated by TTC5/STRAP. Forms a complex with TTC5/STRAP and HSF1; these interactions augment chromatin-bound HSF1 and p300/EP300 histone acetyltransferase activity (By similarity). Part of a complex containing CARM1 and NCOA2/GRIP1. Interacts with ING4 and this interaction may be indirect. Interacts with ING5. Interacts with the C-terminal region of CITED4. Non- sumoylated EP300 preferentially interacts with SENP3. Interacts with SS18L1/CREST. Interacts with ALX1 (via homeobox domain) (By similarity). Interacts with NEUROD1; the interaction is inhibited by NR0B2 (PubMed:9512516). Interacts with TCF3 (By similarity). Interacts (via CREB-binding domain) with MYOCD (via C-terminus) (PubMed:15601857). Interacts with ROCK2 and PPARG. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with IRF1 and this interaction enhances acetylation of p53/TP53 and stimulation of its activity. Interacts with FOXO1; the interaction acetylates FOXO1 and enhances its transcriptional activity. Interacts with ALKBH4 and DDIT3/CHOP. Interacts with KLF15 (By similarity). Interacts with CEBPB and RORA (PubMed:18486321, PubMed:24216764). Interacts with NPAS2, BMAL1 and CLOCK. Interacts with SIRT2 isoform 1, isoform 2 and isoform 5. Interacts with MTA1. Interacts with HDAC4 and HDAC5 in the presence of TFAP2C. Interacts with TRIP4 (By similarity). Interacts with NPAS2 (PubMed:14645221). Directly interacts with ZBTB49; this interaction leads to synergistic transactivation of CDKN1A (By similarity). Interacts with NR4A3 (PubMed:12709428). Interacts with ZNF451 (By similarity). Interacts with ATF5; EP300 is required for ATF5 and CEBPB interaction and DNA binding (PubMed:24216764). Interacts with HSF1. Interacts with ZBTB48/TZAP. Interacts with STAT1; the interaction is enhanced upon IFN-gamma stimulation. Interacts with HNRNPU (via C- terminus); this interaction enhances DNA-binding of HNRNPU to nuclear scaffold/matrix attachment region (S/MAR) elements. Interacts with BCL11B. Interacts with SMAD4; negatively regulated by ZBTB7A. Interacts with DUX4 (via C-terminus). Interacts with NUPR1; this interaction enhances the effect of EP300 on PAX2 transcription factor activity. Interacts with RXRA; the interaction is decreased by 9-cis retinoic acid. NR4A1 competes with EP300 for interaction with RXRA and thereby attenuates EP300 mediated acetylation of RXRA (By similarity). Interacts with RB1 (PubMed:20940255). Interacts with DDX3X; this interaction may facilitate HNF4A acetylation. Interacts with SOX9. Interacts with ATF4; EP300/p300 stabilizes ATF4 and increases its transcriptional activity independently of its catalytic activity by preventing its ubiquitination (By similarity). Interacts with KAT5; promoting KAT5 autoacetylation (By similarity). B2RWS6; A0A087WPF7: Auts2; NbExp=3; IntAct=EBI-3953360, EBI-27122375; B2RWS6; P02340: Tp53; NbExp=3; IntAct=EBI-3953360, EBI-474016; Cytoplasm Nucleus Note=In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Colocalizes with ROCK2 in the nucleus. Localizes to sites of DNA damage. The CRD1 domain (cell cycle regulatory domain 1) mediates transcriptional repression of a subset of p300 responsive genes; it can be de-repressed by CDKN1A/p21WAF1 at least at some promoters. It conatins sumoylation and acetylation sites and the same lysine residues may be targeted for the respective modifications. It is proposed that deacetylation by SIRT1 allows sumoylation leading to suppressed activity (By similarity). Acetylated on Lys at up to 17 positions by intermolecular autocatalysis. Deacetylated in the transcriptional repression domain (CRD1) by SIRT1, preferentially at Lys-1019. Deacetylated by SIRT2, preferentially at Lys-419, Lys-424, Lys-1541, Lys-1545, Lys-1548, Lys- 1698, Lys-1703 and Lys-1706. Citrullinated at Arg-2143 by PADI4, which impairs methylation by CARM1 and promotes interaction with NCOA2/GRIP1. Methylated at Arg-581 and Arg-605 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates apoptotic response. Also methylated at Arg-2143 by CARM1, which impairs interaction with NCOA2/GRIP1 (By similarity). Sumoylated; sumoylation in the transcriptional repression domain (CRD1) mediates transcriptional repression. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3 (By similarity). Probable target of ubiquitination by FBXO3, leading to rapid proteasome-dependent degradation. Phosphorylation at Ser-89 by AMPK reduces interaction with nuclear receptors, such as PPARG (By similarity). Phosphorylated by HIPK2 in a RUNX1-dependent manner. This phosphorylation that activates EP300 happens when RUNX1 is associated with DNA and CBFB. Phosphorylated by ROCK2 and this enhances its activity (By similarity). negative regulation of transcription from RNA polymerase II promoter histone acetyltransferase complex chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding response to hypoxia somitogenesis positive regulation of protein phosphorylation thigmotaxis p53 binding behavioral defense response DNA binding chromatin binding damaged DNA binding transcription cofactor activity transcription coactivator activity antigen binding histone acetyltransferase activity lysine N-acetyltransferase activity, acting on acetyl phosphate as donor protein binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein acetylation internal protein amino acid acetylation apoptotic process positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response cell cycle heart development skeletal muscle tissue development learning or memory circadian rhythm beta-catenin binding protein C-terminus binding transcription factor binding zinc ion binding response to glucose animal organ morphogenesis positive regulation of glycoprotein biosynthetic process positive regulation of gene expression macrophage derived foam cell differentiation positive regulation of cell death positive regulation of neuron projection development positive regulation of muscle atrophy acetyltransferase activity histone acetylation transferase activity transferase activity, transferring acyl groups N-terminal peptidyl-lysine acetylation internal peptidyl-lysine acetylation peptidyl-lysine acetylation protein kinase binding cell differentiation B cell differentiation platelet formation positive regulation of cell growth lung development positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of cellular metabolic process positive regulation of cellular metabolic process negative regulation of protein complex assembly chromatin DNA binding protein destabilization positive regulation of protein binding negative regulation of protein oligomerization positive regulation of collagen biosynthetic process macromolecular complex protein-DNA complex activating transcription factor binding cellular response to UV positive regulation of histone acetylation nuclear hormone receptor binding glucocorticoid receptor binding multicellular organism growth megakaryocyte development swimming response to drug intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator peroxisome proliferator activated receptor binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of DNA binding bHLH transcription factor binding protein kinase B signaling response to estrogen positive regulation by host of viral transcription histone H3 acetylation histone H4 acetylation histone H2B acetylation macromolecular complex binding fat cell differentiation negative regulation of gluconeogenesis positive regulation of translation positive regulation of axon extension positive regulation of cell size positive regulation of gene expression, epigenetic positive regulation of proteolysis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter SMAD binding metal ion binding rhythmic process androgen receptor binding positive regulation of protein secretion protein stabilization mitogen-activated protein kinase binding NF-kappaB binding positive regulation of sequence-specific DNA binding transcription factor activity cartilage development response to calcium ion regulation of angiotensin metabolic process positive regulation of sarcomere organization face morphogenesis negative regulation of cell death regulation of androgen receptor signaling pathway positive regulation of cell growth involved in cardiac muscle cell development protein-DNA complex assembly response to dexamethasone regulation of tubulin deacetylation pre-mRNA intronic binding STAT family protein binding positive regulation of NIK/NF-kappaB signaling positive regulation of protein acetylation positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding protein antigen binding promoter-specific chromatin binding negative regulation of miRNA metabolic process transcription factor activity, sequence-specific DNA binding uc007wws.1 uc007wws.2 uc007wws.3 
ENSMUST00000068397.7 Gm9961 ENSMUST00000068397.7 predicted gene 9961 (from RefSeq NR_033509.1) ENSMUST00000068397.1 ENSMUST00000068397.2 ENSMUST00000068397.3 ENSMUST00000068397.4 ENSMUST00000068397.5 ENSMUST00000068397.6 NR_033509 uc007yfq.1 uc007yfq.2 uc007yfq.3 uc007yfq.4 uc007yfq.5 uc007yfq.6 uc007yfq.1 uc007yfq.2 uc007yfq.3 uc007yfq.4 uc007yfq.5 uc007yfq.6 
ENSMUST00000068399.2 Sprr2e ENSMUST00000068399.2 small proline-rich protein 2E (from RefSeq NM_011471.3) ENSMUST00000068399.1 NM_011471 O70556 SPR2E_MOUSE uc008qdt.1 uc008qdt.2 Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). Cytoplasm Expressed in uterus. During early pregnancy, uterine expression is markedly increased at 1 dpc and 2 dpc, with levels decreasing from 3 dpc onwards. Up-regulated by estrogen in the uterus of ovariectomized animals, with strongly increased expression detected in luminal epithelial cells at 6 and 12 hours after hormone injection. Belongs to the cornifin (SPRR) family. cornified envelope cytoplasm epidermis development keratinocyte differentiation keratinization response to estradiol uc008qdt.1 uc008qdt.2 
ENSMUST00000068407.6 Commd5 ENSMUST00000068407.6 COMM domain containing 5, transcript variant 1 (from RefSeq NM_025536.3) A0A0R4J0U7 A0A0R4J0U7_MOUSE Commd5 ENSMUST00000068407.1 ENSMUST00000068407.2 ENSMUST00000068407.3 ENSMUST00000068407.4 ENSMUST00000068407.5 NM_025536 uc007wms.1 uc007wms.2 uc007wms.3 nucleoplasm cytosol uc007wms.1 uc007wms.2 uc007wms.3 
ENSMUST00000068408.14 Rps15 ENSMUST00000068408.14 ribosomal protein S15, transcript variant 1 (from RefSeq NM_009091.2) ENSMUST00000068408.1 ENSMUST00000068408.10 ENSMUST00000068408.11 ENSMUST00000068408.12 ENSMUST00000068408.13 ENSMUST00000068408.2 ENSMUST00000068408.3 ENSMUST00000068408.4 ENSMUST00000068408.5 ENSMUST00000068408.6 ENSMUST00000068408.7 ENSMUST00000068408.8 ENSMUST00000068408.9 NM_009091 P11174 P62843 Q52KC9 RS15_MOUSE Rig uc007gcn.1 uc007gcn.2 uc007gcn.3 uc007gcn.4 Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the small ribosomal subunit. Cytoplasm Belongs to the universal ribosomal protein uS19 family. ribosomal small subunit assembly ribosomal small subunit export from nucleus RNA binding structural constituent of ribosome protein binding nucleoplasm ribosome rRNA processing translation small ribosomal subunit cytosolic small ribosomal subunit ribosomal small subunit biogenesis synapse liver regeneration uc007gcn.1 uc007gcn.2 uc007gcn.3 uc007gcn.4 
ENSMUST00000068411.5 Ccdc88c ENSMUST00000068411.5 coiled-coil domain containing 88C, transcript variant 1 (from RefSeq NM_026681.5) DAPLE_MOUSE Daple ENSMUST00000068411.1 ENSMUST00000068411.2 ENSMUST00000068411.3 ENSMUST00000068411.4 NM_026681 Q3UVI2 Q6VGS5 uc007ote.1 uc007ote.2 uc007ote.3 Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation. Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling. Promotes apical constriction of cells via ARHGEF18. Homooligomer (PubMed:14750955). Interacts with DVL1 (via PDZ domain); dissociates following initiation of non-canonical Wnt signaling (PubMed:14750955). Interacts (via C-terminus) with ligand- activated Wnt receptor FZD7; competes with DVL1 for binding to FZD7 and displaces DVL1 from ligand-activated FZD7 (By similarity). Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunits GNAI1, GNAI2 and GNAI3 (inactive GDP-bound form); interacts with higher affinity with GNAI1 and GNAI3 than with GNAI2 and interaction leads to G(i) alpha subunit activation (By similarity). Does not interact with GNAO1 (By similarity). Cytoplasm Cell junction Note=Enriched at apical cell junctions. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q6VGS5-1; Sequence=Displayed; Name=2 ; IsoId=Q6VGS5-2; Sequence=VSP_052377; The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins). The PDZ domain is required for localization to apical junctions. Belongs to the CCDC88 family. regulation of protein phosphorylation protein binding cytoplasm centrosome cytosol microtubule binding Wnt signaling pathway PDZ domain binding cytoskeleton-dependent intracellular transport stress-activated protein kinase signaling cascade cytoplasmic microtubule organization protein destabilization protein self-association protein homooligomerization dynein light intermediate chain binding uc007ote.1 uc007ote.2 uc007ote.3 
ENSMUST00000068423.10 Cbln2 ENSMUST00000068423.10 cerebellin 2 precursor protein, transcript variant 5 (from RefSeq NM_001361144.1) CBLN2_MOUSE ENSMUST00000068423.1 ENSMUST00000068423.2 ENSMUST00000068423.3 ENSMUST00000068423.4 ENSMUST00000068423.5 ENSMUST00000068423.6 ENSMUST00000068423.7 ENSMUST00000068423.8 ENSMUST00000068423.9 NM_001361144 Q8BGU2 uc008fva.1 uc008fva.2 The protein encoded by this gene belongs to a family of secreted neuronal glycoproteins. The transcript is broadly expressed in the embryonic and adult brain with higher levels in some regions including the olfactory bulb, thalamus, and cerebral cortex. The protein can bind to presynaptic neurexins and induce synaptogenesis in cultured neurons. Null mutant mice are viable, fertile and do not display obvious neuroanatomical defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Acts as a synaptic organizer in specific subsets of neurons in the brain (PubMed:29691328, PubMed:21410790). Essential for long- term maintenance but not establishment of excitatory synapses (PubMed:29691328, PubMed:30287486). Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the globular C1q domains. The trimers associate via N- terminal cysteine residues to form disulfide-linked hexamers (By similarity). May form homooligomers or heterooligomers with CBLN1 and CBLN3 prior to secretion (PubMed:29782851). Once secreted, does not interact with other CBLN family members. Interacts with GRID2, and more weakly with GRID1. Interacts with NRXN1 and NRXN2 long and short isoforms produced by alternative promoter usage (PubMed:21410790, PubMed:22220752, PubMed:29782851). Weakly interacts with NRXN3 short isoform and not at all with NRXN3 long isoform (PubMed:22220752, PubMed:29782851). Secreted Expressed in various brain regions with higher levels in the olfactory bulb, cerebral cortex, certain thalamic and hypothalamic nuclei, superior and inferior colliculi and some brainstem nuclei. Highly expressed in the dorsal medial habenula. In the developing brain, expressed as early as 10- 13 dpc. Expression level peaks at 18 dpc and gradually decreases afterwards. Mice show impaired synaptic transmission within 3 weeks in interpeduncular target neurons whereas significant decrease in both the synapse density and size seen only after 3 months (PubMed:30287486). Display impaired passive avoidance learning, spatial learning and short-term memory (PubMed:30287486). Double CBLN1 and CBLN2 knockout mice exhibit gait abnormalities, impairments in balance and coordination and develop seizures (PubMed:29691328). Synapse density in the hippocampus is normal in 1-2 months old mice, but severely decreased in 6 month old mice (PubMed:29691328). Triple CBLN1, CBLN2 and CBLN4 knockout mice exhibit impairments in sensory processing and sensorimotor gating, in addition to severe motor deficits, seizures and reduced synapse density in the hippocampus of aging mice (PubMed:29691328). protein binding extracellular region extracellular space positive regulation of synapse assembly glutamatergic synapse regulation of presynapse assembly uc008fva.1 uc008fva.2 
ENSMUST00000068439.13 Pdlim1 ENSMUST00000068439.13 PDZ and LIM domain 1 (elfin) (from RefSeq NM_016861.4) Clim1 ENSMUST00000068439.1 ENSMUST00000068439.10 ENSMUST00000068439.11 ENSMUST00000068439.12 ENSMUST00000068439.2 ENSMUST00000068439.3 ENSMUST00000068439.4 ENSMUST00000068439.5 ENSMUST00000068439.6 ENSMUST00000068439.7 ENSMUST00000068439.8 ENSMUST00000068439.9 NM_016861 O70400 PDLI1_MOUSE Q99K93 uc008hkk.1 uc008hkk.2 uc008hkk.3 uc008hkk.4 Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (By similarity). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). Interacts with ACTN1, ACTN2 and ACTN4 (By similarity). Interacts with PDLIM4 (By similarity). Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line Note=Associates with the actin stress fibers (PubMed:11596114). Expressed in heart, lung, spleen, testis and skeletal muscle. Detected throughout the developing heart. response to hypoxia stress fiber transcription coactivator activity actin binding protein binding transcription factor complex cytoplasm cytoskeleton cell-cell adherens junction regulation of transcription from RNA polymerase II promoter heart development Z disc actin cytoskeleton organization filamentous actin metal ion binding muscle alpha-actinin binding muscle structure development positive regulation of nucleic acid-templated transcription uc008hkk.1 uc008hkk.2 uc008hkk.3 uc008hkk.4 
ENSMUST00000068448.3 Gm9964 ENSMUST00000068448.3 Gm9964 (from geneSymbol) AK039395 ENSMUST00000068448.1 ENSMUST00000068448.2 uc288aql.1 uc288aql.2 uc288aql.1 uc288aql.2 
ENSMUST00000068449.4 Rab39 ENSMUST00000068449.4 RAB39, member RAS oncogene family (from RefSeq NM_175562.3) ENSMUST00000068449.1 ENSMUST00000068449.2 ENSMUST00000068449.3 NM_175562 Q8BHD0 RB39A_MOUSE Rab39a uc009pmm.1 uc009pmm.2 Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K (By similarity). May be involved in multiple neurite formation (PubMed:23624502). Interacts with BECN1. Probably associates with the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex (By similarity). Interacts with UACA. Interacts with isoform a of RASSF1 (PubMed:23294242). Does not interact with isoform c of RASSF1 (PubMed:23294242). Q8BHD0; Q8CGB3-3: Uaca; NbExp=3; IntAct=EBI-10767908, EBI-10767725; Cell membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasmic vesicle, phagosome Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side Lysosome Note=Recruited to phagosomes containing S.aureus or Mycobacterium. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity protein binding GTP binding lysosome plasma membrane intracellular protein transport autophagy protein transport membrane phagocytic vesicle membrane cytoplasmic vesicle Rab protein signal transduction phagocytic vesicle phagosome acidification phagosome-lysosome fusion uc009pmm.1 uc009pmm.2 
ENSMUST00000068456.8 Gabra5 ENSMUST00000068456.8 gamma-aminobutyric acid type A receptor subunit alpha 5, transcript variant 1 (from RefSeq NM_176942.4) ENSMUST00000068456.1 ENSMUST00000068456.2 ENSMUST00000068456.3 ENSMUST00000068456.4 ENSMUST00000068456.5 ENSMUST00000068456.6 ENSMUST00000068456.7 GBRA5_MOUSE NM_176942 Q8BHJ7 uc009heb.1 uc009heb.2 uc009heb.3 Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho (By similarity). Q8BHJ7; Q5WQV5; Xeno; NbExp=4; IntAct=EBI-8069233, EBI-8069271; Postsynaptic cell membrane ; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub- subfamily. behavioral fear response transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity inhibitory extracellular ligand-gated ion channel activity chloride channel activity protein binding nucleoplasm cytosol plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction gamma-aminobutyric acid signaling pathway chemical synaptic transmission brain development sensory perception of sound associative learning membrane integral component of membrane GABA-gated chloride ion channel activity cell junction dendrite dendrite membrane neuronal cell body membrane ion transmembrane transport chloride channel complex regulation of membrane potential neuron projection receptor complex regulation of neuron apoptotic process negative regulation of neuron apoptotic process cell body synapse postsynaptic membrane neuron development GABA receptor binding neurological system process synaptic transmission, GABAergic regulation of postsynaptic membrane potential inner ear receptor cell development innervation cochlea development postsynapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane integral component of postsynaptic specialization membrane chloride transmembrane transport GABA-A receptor complex transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential benzodiazepine receptor activity uc009heb.1 uc009heb.2 uc009heb.3 
ENSMUST00000068457.15 Pphln1 ENSMUST00000068457.15 periphilin 1, transcript variant 2 (from RefSeq NM_175363.5) ENSMUST00000068457.1 ENSMUST00000068457.10 ENSMUST00000068457.11 ENSMUST00000068457.12 ENSMUST00000068457.13 ENSMUST00000068457.14 ENSMUST00000068457.2 ENSMUST00000068457.3 ENSMUST00000068457.4 ENSMUST00000068457.5 ENSMUST00000068457.6 ENSMUST00000068457.7 ENSMUST00000068457.8 ENSMUST00000068457.9 NM_175363 Pphln1 Q3UBL8 Q3UBL8_MOUSE uc007xiy.1 uc007xiy.2 uc007xiy.3 uc007xiy.4 negative regulation of transcription, DNA-templated uc007xiy.1 uc007xiy.2 uc007xiy.3 uc007xiy.4 
ENSMUST00000068505.10 Capn2 ENSMUST00000068505.10 calpain 2 (from RefSeq NM_009794.4) CAN2_MOUSE ENSMUST00000068505.1 ENSMUST00000068505.2 ENSMUST00000068505.3 ENSMUST00000068505.4 ENSMUST00000068505.5 ENSMUST00000068505.6 ENSMUST00000068505.7 ENSMUST00000068505.8 ENSMUST00000068505.9 NM_009794 O08529 O35518 O54843 uc007dye.1 uc007dye.2 uc007dye.3 uc007dye.4 Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (By similarity). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (PubMed:22711986). Reaction=Broad endopeptidase specificity.; EC=3.4.22.53; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 7 Ca(2+) ions. ; Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin. Forms a heterodimer with a small (regulatory) subunit (CAPNS1) (By similarity). Interacts with CPEB3; this leads to cleavage of CPEB3 (PubMed:22711986). Cytoplasm Cell membrane Note=Translocates to the plasma membrane upon Ca(2+) binding. Ubiquitous. Belongs to the peptidase C2 family. chromatin response to hypoxia blastocyst development calcium-dependent cysteine-type endopeptidase activity calcium ion binding nucleus cytoplasm mitochondrial intermembrane space lysosome endoplasmic reticulum Golgi apparatus cytosol plasma membrane focal adhesion proteolysis myoblast fusion female pregnancy cytoskeletal protein binding peptidase activity external side of plasma membrane positive regulation of cardiac muscle cell apoptotic process membrane protein autoprocessing hydrolase activity enzyme binding dendrite pseudopodium regulation of interleukin-6 production cellular response to interferon-beta response to hydrogen peroxide cell projection neuronal cell body membrane raft metal ion binding protein heterodimerization activity behavioral response to pain regulation of cytoskeleton organization proteolysis involved in cellular protein catabolic process cellular response to lipopolysaccharide cellular response to amino acid stimulus perinuclear endoplasmic reticulum positive regulation of neuron death positive regulation of myoblast fusion positive regulation of phosphatidylcholine biosynthetic process uc007dye.1 uc007dye.2 uc007dye.3 uc007dye.4 
ENSMUST00000068532.10 Cgrrf1 ENSMUST00000068532.10 cell growth regulator with ring finger domain 1, transcript variant 1 (from RefSeq NM_026832.4) CGRF1_MOUSE Cgr19 ENSMUST00000068532.1 ENSMUST00000068532.2 ENSMUST00000068532.3 ENSMUST00000068532.4 ENSMUST00000068532.5 ENSMUST00000068532.6 ENSMUST00000068532.7 ENSMUST00000068532.8 ENSMUST00000068532.9 NM_026832 Q3U3F1 Q8BMJ7 Q8CI24 uc007thl.1 uc007thl.2 uc007thl.3 Able to inhibit growth in several cell lines. Nucleus Endoplasmic reticulum molecular_function nucleus nucleoplasm endoplasmic reticulum cell cycle cell cycle arrest negative regulation of cell growth intracellular membrane-bounded organelle metal ion binding uc007thl.1 uc007thl.2 uc007thl.3 
ENSMUST00000068545.6 Sugct ENSMUST00000068545.6 succinyl-CoA glutarate-CoA transferase (from RefSeq NM_138654.3) ENSMUST00000068545.1 ENSMUST00000068545.2 ENSMUST00000068545.3 ENSMUST00000068545.4 ENSMUST00000068545.5 G3X9F8 NM_138654 Q7TNE1 SUCHY_MOUSE uc007pnx.1 uc007pnx.2 uc007pnx.3 uc007pnx.4 uc007pnx.5 uc007pnx.6 Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3- hydroxymethylglutarate (By similarity). Reaction=3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-hydroxy-3- methylglutaryl-CoA + succinate; Xref=Rhea:RHEA:12284, ChEBI:CHEBI:17325, ChEBI:CHEBI:30031, ChEBI:CHEBI:43074, ChEBI:CHEBI:57292; EC=2.8.3.13; Mitochondrion Belongs to the CoA-transferase III family. mitochondrion CoA-transferase activity transferase activity succinate-hydroxymethylglutarate CoA-transferase activity uc007pnx.1 uc007pnx.2 uc007pnx.3 uc007pnx.4 uc007pnx.5 uc007pnx.6 
ENSMUST00000068551.9 Xlr4c ENSMUST00000068551.9 Belongs to the XLR/SYCP3 family. (from UniProt Q3TKR2) AK013623 ENSMUST00000068551.1 ENSMUST00000068551.2 ENSMUST00000068551.3 ENSMUST00000068551.4 ENSMUST00000068551.5 ENSMUST00000068551.6 ENSMUST00000068551.7 ENSMUST00000068551.8 Q3TKR2 Q3TKR2_MOUSE Xlr4b Xlr4c uc292oqq.1 uc292oqq.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc292oqq.1 uc292oqq.2 
ENSMUST00000068569.5 Bcl2a1b ENSMUST00000068569.5 B cell leukemia/lymphoma 2 related protein A1b (from RefSeq NM_007534.3) Bcl2a1b ENSMUST00000068569.1 ENSMUST00000068569.2 ENSMUST00000068569.3 ENSMUST00000068569.4 NM_007534 Q497M6 Q497M6_MOUSE uc009qzj.1 uc009qzj.2 uc009qzj.3 uc009qzj.4 Belongs to the Bcl-2 family. mitochondrial outer membrane intrinsic apoptotic signaling pathway in response to DNA damage protein homodimerization activity regulation of apoptotic process negative regulation of apoptotic process protein heterodimerization activity BH domain binding extrinsic apoptotic signaling pathway in absence of ligand uc009qzj.1 uc009qzj.2 uc009qzj.3 uc009qzj.4 
ENSMUST00000068580.4 Dcpp1 ENSMUST00000068580.4 demilune cell and parotid protein 1, transcript variant 1 (from RefSeq NM_019910.3) Dcpp1 ENSMUST00000068580.1 ENSMUST00000068580.2 ENSMUST00000068580.3 L7N1X9 L7N1X9_MOUSE NM_019910 uc008atz.1 uc008atz.2 blastocyst development molecular_function extracellular space uc008atz.1 uc008atz.2 
ENSMUST00000068581.9 Gja1 ENSMUST00000068581.9 gap junction protein, alpha 1 (from RefSeq NM_010288.3) CXA1_MOUSE Cxn-43 ENSMUST00000068581.1 ENSMUST00000068581.2 ENSMUST00000068581.3 ENSMUST00000068581.4 ENSMUST00000068581.5 ENSMUST00000068581.6 ENSMUST00000068581.7 ENSMUST00000068581.8 NM_010288 P23242 Q544I7 Q8CE05 uc007fcd.1 uc007fcd.2 uc007fcd.3 uc007fcd.4 Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Plays an essential role in gap junction communication in the ventricles (PubMed:26403541). Connexin 43 is possibly the ATP-induced pore of mouse macrophages. A connexon is composed of a hexamer of connexins. Interacts with CSNK1D (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts (via C-terminus) with TJP1 (By similarity). Interacts (via C-terminus) with SRC (via SH3 domain) (By similarity). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain). Interacts with CNST. Interacts with SGSM3. Interacts with NOV (By similarity). Interacts with TMEM65 (PubMed:26403541). P23242; Q8CDJ3: Atg14; NbExp=2; IntAct=EBI-298630, EBI-3506699; P23242; Q8C0J2: Atg16l1; NbExp=2; IntAct=EBI-298630, EBI-769195; P23242; Q7TT37: Elp1; NbExp=3; IntAct=EBI-298630, EBI-8418161; P23242; P28231: Gjb3; NbExp=2; IntAct=EBI-298630, EBI-1767245; P23242; P28229: Gjc1; NbExp=2; IntAct=EBI-298630, EBI-1767271; P23242; Q6NZM9: Hdac4; NbExp=2; IntAct=EBI-298630, EBI-646397; P23242; Q9Z2V6: Hdac5; NbExp=2; IntAct=EBI-298630, EBI-645339; P23242; Q6PF93: Pik3c3; NbExp=4; IntAct=EBI-298630, EBI-6678149; P23242; Q8VD65: Pik3r4; NbExp=3; IntAct=EBI-298630, EBI-6678184; P23242; P28867: Prkcd; NbExp=4; IntAct=EBI-298630, EBI-1551324; P23242; P16054: Prkce; NbExp=3; IntAct=EBI-298630, EBI-298451; P23242; P05480: Src; NbExp=3; IntAct=EBI-298630, EBI-298680; P23242; P39447: Tjp1; NbExp=4; IntAct=EBI-298630, EBI-79508; P23242; P68254: Ywhaq; NbExp=3; IntAct=EBI-298630, EBI-400675; P23242; Q63664: Kcnj8; Xeno; NbExp=4; IntAct=EBI-298630, EBI-6991142; Cell membrane ulti-pass membrane protein Cell junction, gap junction Endoplasmic reticulum Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and proper localization at ICD is dependent on TMEM65. Expressed in heart, non-sensory epithelial cells, and in fibrocytes of the spiral ligament and the spiral limbus. Expressed in bladder smooth muscle cells (at protein level). Expressed in astrocytes (at protein level) (PubMed:15213231). At 7.5 dpc, expressed in the embryo, but not in the extraembryonic region containing the ectoplacental cone. In bladder smooth muscle cells, exhibits night/day variations with low levels during the sleep phase, at circadian time (CT) 4-12 (at protein level). Down-regulation during the night allows increase in bladder capacity, avoiding disturbance of sleep by micturition. Expression starts to increase around CT12 and forms a plateau during the active phase (CT16-24) (at protein level). Circadian transcription is activated by NR1D1. Up-regulated by SP1 and SP3. Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity. Phosphorylation at Ser-368 by PRKCD triggers its internalization into small vesicles leading to proteasome-mediated degradation (By similarity). Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2 (By similarity). Acetylated in the developing cortex; leading to delocalization from the cell membrane. S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication. Mutant mice die shortly after birth. Belongs to the connexin family. Alpha-type (group II) subfamily. establishment of mitotic spindle orientation osteoblast differentiation in utero embryonic development neuron migration negative regulation of endothelial cell proliferation heart looping epithelial cell maturation lens development in camera-type eye chronic inflammatory response response to ischemia positive regulation of glomerular filtration endothelium development atrial ventricular junction remodeling epicardial cell to mesenchymal cell transition receptor binding gap junction channel activity protein binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane lysosome endosome early endosome late endosome multivesicular body endoplasmic reticulum Golgi apparatus cytosol intermediate filament plasma membrane cell-cell junction fascia adherens gap junction connexin complex apoptotic process cell communication signal transduction positive regulation of cytosolic calcium ion concentration cell-cell signaling spermatogenesis heart development adult heart development beta-catenin binding regulation of heart contraction negative regulation of cell proliferation male gonad development response to pH response to glucose vascular transport positive regulation of gene expression negative regulation of gene expression cell communication by chemical coupling cell communication by electrical coupling positive regulation of cell communication by chemical coupling intercalated disc ion transmembrane transporter activity tubulin binding ATP transport membrane integral component of membrane apical plasma membrane lateral plasma membrane SH3 domain binding protein domain specific binding transmembrane transporter activity regulation of transmembrane transporter activity cell junction PDZ domain binding negative regulation of cell growth regulation of bone mineralization positive regulation of insulin secretion negative regulation of gonadotropin secretion response to estradiol response to lipopolysaccharide response to retinoic acid macromolecular complex ion transmembrane transport response to fluid shear stress cellular protein localization embryonic heart tube development T cell proliferation T cell activation embryonic digit morphogenesis regulation of apoptotic process alpha-tubulin binding intracellular membrane-bounded organelle contractile fiber skeletal muscle tissue regeneration response to peptide hormone cell-cell contact zone membrane raft cell-cell junction organization positive regulation of protein catabolic process positive regulation of striated muscle tissue development positive regulation of vasoconstriction decidualization bone remodeling regulation of bone remodeling beta-tubulin binding blood vessel morphogenesis neuron projection morphogenesis protein oligomerization regulation of calcium ion transport gap junction hemi-channel activity transmembrane transport negative regulation of cardiac muscle cell proliferation milk ejection reflex regulation of ventricular cardiac muscle cell membrane repolarization regulation of blood vessel remodeling bone development regulation of atrial cardiac muscle cell membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization negative regulation of wound healing cardiac conduction occluding junction connexin binding cellular response to mechanical stimulus cellular response to parathyroid hormone stimulus cellular response to pH cell communication by electrical coupling involved in cardiac conduction gap junction channel activity involved in cardiac conduction electrical coupling establishment of epithelial cell polarity scaffold protein binding disordered domain specific binding microtubule-based transport negative regulation of trophoblast cell migration gap junction channel activity involved in cell communication by electrical coupling positive regulation of morphogenesis of an epithelium positive regulation of mesodermal cell differentiation protein tyrosine kinase binding negative regulation of DNA biosynthetic process positive regulation of stem cell proliferation regulation of bicellular tight junction assembly positive regulation of behavioral fear response uc007fcd.1 uc007fcd.2 uc007fcd.3 uc007fcd.4 
ENSMUST00000068584.7 Cd48 ENSMUST00000068584.7 CD48 antigen, transcript variant 1 (from RefSeq NM_007649.5) Bcm-1 CD48_MOUSE ENSMUST00000068584.1 ENSMUST00000068584.2 ENSMUST00000068584.3 ENSMUST00000068584.4 ENSMUST00000068584.5 ENSMUST00000068584.6 NM_007649 P18181 Q545K2 uc007doz.1 uc007doz.2 uc007doz.3 Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:9881969, PubMed:21278219). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation (PubMed:9881969). Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK- cells (By similarity) (PubMed:9881969, PubMed:21278219). Interacts with CD2 (PubMed:1383383). Interacts with CD244 (PubMed:17950006). Interacts with LCK (By similarity). Cell membrane ; Lipid-anchor, GPI-anchor Secreted Deletion mice do not develop signs of autoimmunity, but exhibit defects in induction of tolerance. regulation of adaptive immune response antigen binding protein binding plasma membrane signal transduction external side of plasma membrane membrane anchored component of membrane macromolecular complex signaling receptor activity T cell activation membrane raft mast cell activation anchored component of plasma membrane uc007doz.1 uc007doz.2 uc007doz.3 
ENSMUST00000068592.5 Ifng ENSMUST00000068592.5 interferon gamma (from RefSeq NM_008337.4) ENSMUST00000068592.1 ENSMUST00000068592.2 ENSMUST00000068592.3 ENSMUST00000068592.4 IFNG_MOUSE NM_008337 P01580 Q542B8 uc007hdy.1 uc007hdy.2 uc007hdy.3 uc007hdy.4 This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: K00083.1, M28621.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849388 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:8456301, PubMed:11585387). Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (PubMed:20535209, PubMed:25078851). Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization. P01580; P52293: Kpna2; NbExp=5; IntAct=EBI-7892102, EBI-3043908; Secreted Released primarily from activated T lymphocytes. Deletion mutant mice show no special developmental defects, and their immune system appear to develop normally. However, they show susceptibility to bacterial or viral infections such as vaccinia virus or Theiler's murine encephalomyelitis virus, despite normal cytotoxic and T-helper cell responses. Belongs to the type II (or gamma) interferon family. negative regulation of transcription from RNA polymerase II promoter microglial cell activation neutrophil apoptotic process positive regulation of protein phosphorylation regulation of the force of heart contraction adaptive immune response CD8-positive, alpha-beta T cell differentiation involved in immune response cytokine activity interferon-gamma receptor binding protein binding extracellular region extracellular space cytoplasm regulation of transcription, DNA-templated apoptotic process inflammatory cell apoptotic process immune response humoral immune response cell cycle arrest JAK-STAT cascade positive regulation of cell proliferation negative regulation of cell proliferation response to virus external side of plasma membrane positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration regulation of protein ADP-ribosylation positive regulation of receptor biosynthetic process antigen processing and presentation neutrophil chemotaxis negative regulation of epithelial cell differentiation endoplasmic reticulum unfolded protein response positive regulation of protein complex assembly negative regulation of myelination positive regulation of synaptic transmission, cholinergic negative regulation of interleukin-17 production positive regulation of interleukin-12 production positive regulation of interleukin-23 production positive regulation of tumor necrosis factor production positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of smooth muscle cell apoptotic process regulation of growth positive regulation of T cell proliferation positive regulation of protein import into nucleus response to drug positive regulation of tyrosine phosphorylation of STAT protein positive regulation of tumor necrosis factor biosynthetic process defense response to bacterium defense response to protozoan neuron projection positive regulation of apoptotic process perikaryon positive regulation by host of viral process positive regulation of chemokine biosynthetic process positive regulation of interleukin-12 biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of interleukin-6 biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of neuron differentiation negative regulation of osteoclast differentiation positive regulation of osteoclast differentiation positive regulation of cell adhesion positive regulation of glycolytic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter astrocyte activation negative regulation of fibroblast proliferation positive regulation of isotype switching to IgG isotypes negative regulation of smooth muscle cell proliferation regulation of defense response to virus by host positive regulation of interleukin-1 beta secretion positive regulation of interleukin-1 beta biosynthetic process positive regulation of phagocytosis positive regulation of neurogenesis regulation of immune response regulation of insulin secretion T cell receptor signaling pathway sensory perception of mechanical stimulus positive regulation of membrane protein ectodomain proteolysis positive regulation of nitrogen compound metabolic process defense response to virus positive regulation of killing of cells of other organism positive regulation of nitric-oxide synthase biosynthetic process regulation of glial cell proliferation interferon-gamma-mediated signaling pathway positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity positive regulation of fructose 1,6-bisphosphate metabolic process positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1-monooxygenase activity cellular response to lipopolysaccharide cellular response to interleukin-18 positive regulation of protein serine/threonine kinase activity negative regulation of glomerular mesangial cell proliferation positive regulation of protein deacetylation extrinsic apoptotic signaling pathway regulation of neuronal action potential negative regulation of beta-amyloid clearance positive regulation of neuron death positive regulation of cellular respiration positive regulation of beta-amyloid formation negative regulation of tau-protein kinase activity positive regulation of ferrous iron import across plasma membrane positive regulation of tumor necrosis factor secretion positive regulation of NMDA glutamate receptor activity positive regulation of core promoter binding positive regulation of tumor necrosis factor (ligand) superfamily member 11 production regulation of hepatocyte proliferation uc007hdy.1 uc007hdy.2 uc007hdy.3 uc007hdy.4 
ENSMUST00000068593.9 C1ra ENSMUST00000068593.9 complement component 1, r subcomponent A (from RefSeq NM_023143.3) C1RA_MOUSE C1r ENSMUST00000068593.1 ENSMUST00000068593.2 ENSMUST00000068593.3 ENSMUST00000068593.4 ENSMUST00000068593.5 ENSMUST00000068593.6 ENSMUST00000068593.7 ENSMUST00000068593.8 NM_023143 Q8CG16 Q99KI6 Q9ET60 uc009dra.1 uc009dra.2 uc009dra.3 uc009dra.4 C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Reaction=Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).; EC=3.4.21.41; C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds (By similarity). The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Belongs to the peptidase S1 family. immune system process serine-type endopeptidase activity calcium ion binding extracellular space proteolysis complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity zymogen activation innate immune response uc009dra.1 uc009dra.2 uc009dra.3 uc009dra.4 
ENSMUST00000068603.8 Iqgap2 ENSMUST00000068603.8 IQ motif containing GTPase activating protein 2 (from RefSeq NM_027711.1) ENSMUST00000068603.1 ENSMUST00000068603.2 ENSMUST00000068603.3 ENSMUST00000068603.4 ENSMUST00000068603.5 ENSMUST00000068603.6 ENSMUST00000068603.7 IQGA2_MOUSE NM_027711 Q3UQ44 uc007rmo.1 uc007rmo.2 uc007rmo.3 Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. Sequence=AK147360; Type=Frameshift; Evidence=; calmodulin binding phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm microtubule microvillus signal transduction cell surface Rho GTPase binding lamellipodium filopodium Arp2/3 complex-mediated actin nucleation regulation of GTPase activity Rac GTPase binding actin filament binding thrombin-activated receptor signaling pathway Arp2/3 complex binding uc007rmo.1 uc007rmo.2 uc007rmo.3 
ENSMUST00000068613.5 Fam72a ENSMUST00000068613.5 family with sequence similarity 72, member A (from RefSeq NM_175382.5) B2RR49 ENSMUST00000068613.1 ENSMUST00000068613.2 ENSMUST00000068613.3 ENSMUST00000068613.4 FA72A_MOUSE NM_175382 Q3KQN3 Q8BFZ8 uc007cnk.1 uc007cnk.2 uc007cnk.3 uc007cnk.4 May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation (By similarity). Interacts with UNG. Cytoplasm Mitochondrion Expressed at high levels in stomach and also in kidney and, at low levels, in heart (at protein level). In the stomach, highly expressed in foveolar cells, parietal cells and chief cells (at protein level). In kidney, expressed in endothelial cells, mesangial and epithelial cells (parietal and visceral epithelium) around glomerulus (at protein level). Belongs to the FAM72 family. molecular_function cytoplasm mitochondrion cytosol membrane negative regulation of brain-derived neurotrophic factor-activated receptor activity positive regulation of apoptotic process intracellular membrane-bounded organelle uc007cnk.1 uc007cnk.2 uc007cnk.3 uc007cnk.4 
ENSMUST00000068625.5 Klk15 ENSMUST00000068625.5 kallikrein related-peptidase 15 (from RefSeq NM_174865.2) ENSMUST00000068625.1 ENSMUST00000068625.2 ENSMUST00000068625.3 ENSMUST00000068625.4 KLK15 Klk15 NM_174865 Q8CGR4 Q8CGR4_MOUSE uc009gnz.1 uc009gnz.2 uc009gnz.3 serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity secretory granule uc009gnz.1 uc009gnz.2 uc009gnz.3 
ENSMUST00000068631.4 Fev ENSMUST00000068631.4 FEV transcription factor, ETS family member (from RefSeq NM_153111.2) ENSMUST00000068631.1 ENSMUST00000068631.2 ENSMUST00000068631.3 FEV_MOUSE NM_153111 Pet1 Q8QZW2 uc007bnh.1 uc007bnh.2 uc007bnh.3 uc007bnh.4 Functions as a transcriptional regulator. May function as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. Nucleus Expressed in central serotonergic neurons. First expressed at 11 dpc in the rostral cluster of serotonergic neurons. During development, expression is restricted to serotonergic neurons located in the raphe nuclei. Mice display heightened aggressive and anxiety- like behaviors. They also display an extended and exacerbated period of breathing instability immediately after birth which results in an increased risk of death. This is associated with loss of the differentiation of a large number of the serotonin (5-HT) neurons without major structural abnormalities of the brain. Belongs to the ETS family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development nervous system development positive regulation of gene expression nuclear speck cell differentiation neuron maturation neuronal cell body sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter neuron fate specification regulation of serotonin uptake regulation of serotonin biosynthetic process uc007bnh.1 uc007bnh.2 uc007bnh.3 uc007bnh.4 
ENSMUST00000068641.8 Sertad3 ENSMUST00000068641.8 SERTA domain containing 3 (from RefSeq NM_133210.2) ENSMUST00000068641.1 ENSMUST00000068641.2 ENSMUST00000068641.3 ENSMUST00000068641.4 ENSMUST00000068641.5 ENSMUST00000068641.6 ENSMUST00000068641.7 NM_133210 Q9ERC3 Rbt1 SRTD3_MOUSE uc009fwg.1 uc009fwg.2 uc009fwg.3 Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms (By similarity). Plays a role in the late phase response of TLR-induced immune effector expression (PubMed:28750197). Strong transcriptional coactivator (By similarity). Interacts with RPA2. Nucleus Nucleus, nucleolus protein binding nucleus nucleolus cytoplasm regulation of transcription, DNA-templated negative regulation of cell growth positive regulation of transcription, DNA-templated uc009fwg.1 uc009fwg.2 uc009fwg.3 
ENSMUST00000068654.5 Foxd2 ENSMUST00000068654.5 forkhead box D2 (from RefSeq NM_008593.3) A2AD43 ENSMUST00000068654.1 ENSMUST00000068654.2 ENSMUST00000068654.3 ENSMUST00000068654.4 FOXD2_MOUSE Mf2 NM_008593 O35392 uc012dix.1 uc012dix.2 uc012dix.3 Probable transcription factor involved in embryogenesis and somatogenesis. Nucleus Expressed at high levels in the ventral region of newly formed somites, in sclerotomal derivatives, in lateral plate and cephalic mesoderm and in the first and second branchial arches. Other regions of mesodermal expression include the developing tongue, meninges, nose, whiskers, kidney, genital tubercule and limb joints. In the nervous system it is transcribed in restricted regions of the mid- and forebrain. RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter anatomical structure morphogenesis cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc012dix.1 uc012dix.2 uc012dix.3 
ENSMUST00000068664.7 Neo1 ENSMUST00000068664.7 neogenin, transcript variant 1 (from RefSeq NM_008684.3) ENSMUST00000068664.1 ENSMUST00000068664.2 ENSMUST00000068664.3 ENSMUST00000068664.4 ENSMUST00000068664.5 ENSMUST00000068664.6 NEO1_MOUSE NM_008684 Neo1 Ngn P97798 uc009pxk.1 uc009pxk.2 uc009pxk.3 uc009pxk.4 Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. Interacts with BMP2, BMP4, BMP6, and BMP7 (By similarity). Interacts with RGMA and RGMB. Interacts with MYO10. P97798; Q6NW40: RGMB; Xeno; NbExp=2; IntAct=EBI-774991, EBI-16155464; P97798-1; F8VQB6: Myo10; NbExp=2; IntAct=EBI-40201781, EBI-6445959; Cell membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P97798-1; Sequence=Displayed; Name=2; IsoId=P97798-2; Sequence=VSP_002594; Name=3; IsoId=P97798-3; Sequence=VSP_002595; Name=4; IsoId=P97798-4; Sequence=VSP_002596; Name=5; IsoId=P97798-5; Sequence=VSP_002597; Widely expressed. Expressed ubiquitously throughout the mid to late stages of gestation and in adult tissues. Strong expression is observed in the ventral region of the ventricular zone of the 15.5 dpc mouse neural tube, as well as in the ventricular zones of the mesencephalon and rhombencephalon. Isoform 3 and isoform 4 are expressed at higher level compared to other isoforms between 11.5 dpc and 16.5 dpc. The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules. [Isoform 3]: Expression developmentally regulated. [Isoform 4]: Expression developmentally regulated. [Isoform 5]: Expression developmentally regulated. Belongs to the immunoglobulin superfamily. DCC family. Sequence=CAA70727.1; Type=Frameshift; Evidence=; neuron migration protein binding nucleoplasm Golgi apparatus plasma membrane integral component of plasma membrane regulation of transcription, DNA-templated cell adhesion nervous system development axon guidance myoblast fusion cell surface membrane integral component of membrane positive regulation of BMP signaling pathway signaling receptor activity co-receptor binding neuronal cell body cadherin binding regulation of axon regeneration negative regulation of axon regeneration negative regulation of protein secretion iron ion homeostasis BMP receptor binding intracellular vesicle plasma membrane protein complex negative regulation of neuron death regulation of neuron migration uc009pxk.1 uc009pxk.2 uc009pxk.3 uc009pxk.4 
ENSMUST00000068686.13 Calcoco2 ENSMUST00000068686.13 calcium binding and coiled-coil domain 2 (from RefSeq NM_001271018.2) A2A6M5 CACO2_MOUSE Calcoco2 ENSMUST00000068686.1 ENSMUST00000068686.10 ENSMUST00000068686.11 ENSMUST00000068686.12 ENSMUST00000068686.2 ENSMUST00000068686.3 ENSMUST00000068686.4 ENSMUST00000068686.5 ENSMUST00000068686.6 ENSMUST00000068686.7 ENSMUST00000068686.8 ENSMUST00000068686.9 NM_001271018 Ndp52 Ndp52l1 Q3TK36 Q3TKZ6 Q3TL30 Q9CWE3 uc033fzk.1 uc033fzk.2 uc033fzk.3 Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen- containing autophagosome maturation (By similarity). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity). Dimer. Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Interacts with MYO6 (By similarity). Interacts with GEMIN4. Interacts with ATG8 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. Interacts with ATG8 family member MAP1LC3C. Interacts with LGALS8. Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and CALCOCO2 (By similarity). Interacts with AZI2 (By similarity). Cytoplasm, perinuclear region Cytoplasm, cytoskeleton Cytoplasmic vesicle, autophagosome membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A2A6M5-1; Sequence=Displayed; Name=2; IsoId=A2A6M5-2; Sequence=VSP_029832; Name=3; IsoId=A2A6M5-3; Sequence=VSP_029833; Name=4; IsoId=A2A6M5-4; Sequence=VSP_029830; Name=5; IsoId=A2A6M5-5; Sequence=VSP_029831; Expression is limited to the pluripotent cells of the early embryo and the germline. Expressed in blastocysts, epiblasts and purified primordial germ cells. The LGALS8-binding domain is essential for the recruitment to cytosol-exposed infecting bacteria. The CLIR (LC3C-interacting region) motif is required for interaction with MAP1LC3C, but dispensable for CALCOCO2-mediated autophagosome maturation. The LIR-like motif is required for interaction with MAP1LC3A, MAP1LC3B and GABARAPL2, as well as for CALCOCO2-mediated autophagosome maturation. Belongs to the CALCOCO family. Sequence=BAE38997.1; Type=Frameshift; Evidence=; autophagosome membrane cytoplasm autophagosome cytoskeleton autophagy membrane PML body cytoplasmic vesicle perinuclear region of cytoplasm xenophagy positive regulation of autophagosome maturation uc033fzk.1 uc033fzk.2 uc033fzk.3 
ENSMUST00000068693.12 Wdr86 ENSMUST00000068693.12 WD repeat domain 86 (from RefSeq NM_001081441.1) D3Z757 D3Z757_MOUSE ENSMUST00000068693.1 ENSMUST00000068693.10 ENSMUST00000068693.11 ENSMUST00000068693.2 ENSMUST00000068693.3 ENSMUST00000068693.4 ENSMUST00000068693.5 ENSMUST00000068693.6 ENSMUST00000068693.7 ENSMUST00000068693.8 ENSMUST00000068693.9 NM_001081441 Wdr86 uc008wsh.1 uc008wsh.2 uc008wsh.3 molecular_function cellular_component biological_process uc008wsh.1 uc008wsh.2 uc008wsh.3 
ENSMUST00000068697.11 Kcmf1 ENSMUST00000068697.11 potassium channel modulatory factor 1, transcript variant 1 (from RefSeq NM_019715.2) Debt91 ENSMUST00000068697.1 ENSMUST00000068697.10 ENSMUST00000068697.2 ENSMUST00000068697.3 ENSMUST00000068697.4 ENSMUST00000068697.5 ENSMUST00000068697.6 ENSMUST00000068697.7 ENSMUST00000068697.8 ENSMUST00000068697.9 KCMF1_MOUSE NM_019715 Q80UY2 Q9WUM2 uc009cjd.1 uc009cjd.2 uc009cjd.3 uc009cjd.4 Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80UY2-1; Sequence=Displayed; Name=2; IsoId=Q80UY2-2; Sequence=VSP_035227; Testis, liver, kidney, heart and skeletal muscle. Expressed throughout embryonic development, with much higher expression after day 15, when many organs including the kidney are undergoing extensive branching morphogenesis. Up-regulated during growth factor-induced branching tubulogenesis. Belongs to the KCMF1 family. nucleic acid binding cytosol zinc ion binding protein ubiquitination transferase activity metal ion binding ubiquitin protein ligase activity uc009cjd.1 uc009cjd.2 uc009cjd.3 uc009cjd.4 
ENSMUST00000068700.7 Wdr6 ENSMUST00000068700.7 WD repeat domain 6 (from RefSeq NM_031392.4) ENSMUST00000068700.1 ENSMUST00000068700.2 ENSMUST00000068700.3 ENSMUST00000068700.4 ENSMUST00000068700.5 ENSMUST00000068700.6 NM_031392 Q99ME2 WDR6_MOUSE uc009rqj.1 uc009rqj.2 uc009rqj.3 Together with methyltransferase FTSJ1, methylates the 2'-O- ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (By similarity). Required for the correct positioning of the substrate tRNA for methylation (By similarity). Required to suppress amino acid starvation-induced autophagy (By similarity). Enhances the STK11/LKB1-induced cell growth suppression activity (By similarity). Interacts with FTSJ1; the interaction is direct, and required for 2'-O-methylation of position 34 in substrate tRNAs (By similarity). Interacts with IRS4 (By similarity). Interacts with STK11/LKB1 (By similarity). Cytoplasm Note=Colocalizes in the cytoplasm with STK11/LKB1. Belongs to the WD repeat WDR6 family. cytoplasm cytosol plasma membrane cell cycle cell cycle arrest negative regulation of cell proliferation negative regulation of autophagy macromolecular complex insulin receptor substrate binding COP9 signalosome uc009rqj.1 uc009rqj.2 uc009rqj.3 
ENSMUST00000068714.7 Sos1 ENSMUST00000068714.7 SOS Ras/Rac guanine nucleotide exchange factor 1 (from RefSeq NM_009231.2) ENSMUST00000068714.1 ENSMUST00000068714.2 ENSMUST00000068714.3 ENSMUST00000068714.4 ENSMUST00000068714.5 ENSMUST00000068714.6 NM_009231 Q62244 Q62245 SOS1_MOUSE uc008drg.1 uc008drg.2 uc008drg.3 Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (By similarity). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (PubMed:10499589, PubMed:11524436). Interacts (via C-terminus) with GRB2 (via SH3 domain). Forms a complex with phosphorylated MUC1 and GRB2 (via its SH3 domains). Interacts with phosphorylated LAT2. Interacts with NCK1 and NCK2 (By similarity). Part of a complex consisting of ABI1, EPS8 and SOS1 (PubMed:10499589, PubMed:11524436). Interacts (Ser-1120 and Ser-1147 phosphorylated form) with YWHAB and YWHAE (By similarity). Q62245; Q60631: Grb2; NbExp=7; IntAct=EBI-1693, EBI-1688; Q62245; P62993: GRB2; Xeno; NbExp=4; IntAct=EBI-1693, EBI-401755; Q62245; P62993-1: GRB2; Xeno; NbExp=2; IntAct=EBI-1693, EBI-15787932; Q62245; P29355: sem-5; Xeno; NbExp=2; IntAct=EBI-1693, EBI-315286; Q62245; P26663; Xeno; NbExp=2; IntAct=EBI-1693, EBI-6857429; Expressed in most embryonic and adult tissues. Phosphorylation at Ser-1120 and Ser-1147 by RPS6KA3 create YWHAB and YWHAE binding sites and which contribute to the negative regulation of EGF-induced MAPK1/3 phosphorylation. nucleosome B cell homeostasis hair follicle development lymphocyte homeostasis heart morphogenesis cardiac atrium morphogenesis pericardium morphogenesis DNA binding guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding cytoplasm cytosol plasma membrane epidermal growth factor receptor signaling pathway small GTPase mediated signal transduction Ras protein signal transduction vitellogenesis postsynaptic density SH3 domain binding regulation of T cell differentiation in thymus regulation of Rho protein signal transduction multicellular organism growth regulation of T cell proliferation neuronal cell body positive regulation of epidermal growth factor receptor signaling pathway positive regulation of Ras protein signal transduction protein heterodimerization activity neurotrophin TRK receptor signaling pathway blood vessel morphogenesis positive regulation of small GTPase mediated signal transduction palate development eyelid development in camera-type eye heart trabecula morphogenesis midbrain morphogenesis regulation of pro-B cell differentiation uc008drg.1 uc008drg.2 uc008drg.3 
ENSMUST00000068725.10 Mtarc2 ENSMUST00000068725.10 mitochondrial amidoxime reducing component 2, transcript variant 1 (from RefSeq NM_133684.4) ENSMUST00000068725.1 ENSMUST00000068725.2 ENSMUST00000068725.3 ENSMUST00000068725.4 ENSMUST00000068725.5 ENSMUST00000068725.6 ENSMUST00000068725.7 ENSMUST00000068725.8 ENSMUST00000068725.9 MARC2_MOUSE Marc2 Mg87 Mosc2 NM_133684 Q922Q1 uc007dyq.1 uc007dyq.2 uc007dyq.3 Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L- arginine = 2 Fe(III)-[cytochrome b5] + H2O + L-arginine; Xref=Rhea:RHEA:61644, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:32682, ChEBI:CHEBI:60107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61645; Evidence=; Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Evidence=; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. ; Component of a complex composed of cytochrome b5, NADH- cytochrome b5 reductase (CYB5R3) and MTARC2. Mitochondrion outer membrane ; Peripheral membrane protein Peroxisome Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. catalytic activity mitochondrion mitochondrial outer membrane mitochondrial inner membrane peroxisome nitrate reductase activity membrane oxidoreductase activity molybdenum ion binding pyridoxal phosphate binding nitrate metabolic process molybdopterin cofactor binding oxidation-reduction process uc007dyq.1 uc007dyq.2 uc007dyq.3 
ENSMUST00000068755.14 Bhlhb9 ENSMUST00000068755.14 basic helix-loop-helix domain containing, class B9, transcript variant 1 (from RefSeq NM_198161.3) ENSMUST00000068755.1 ENSMUST00000068755.10 ENSMUST00000068755.11 ENSMUST00000068755.12 ENSMUST00000068755.13 ENSMUST00000068755.2 ENSMUST00000068755.3 ENSMUST00000068755.4 ENSMUST00000068755.5 ENSMUST00000068755.6 ENSMUST00000068755.7 ENSMUST00000068755.8 ENSMUST00000068755.9 GASP3_MOUSE Gprasp3 Kiaa1701 NM_198161 Q3U0C1 Q69ZD0 Q6PB60 uc009uhw.1 uc009uhw.2 uc009uhw.3 Survival and differentiation promoting protein that plays a role in the regulation of neurosynaptogenesis. Induces phosphatase PP2A activity which results in APP dephosphorylation and inhibits BACE1- mediated processing of APP. Homodimer. Cytoplasm Nucleus Note=Mainly cytoplasmic, and nuclear at lower level. Belongs to the GPRASP family. Despite its name, no basic helix-loop-helix (bHLH) domain is detected by any prediction tool. Sequence=BAD32514.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAD32514.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; nucleus nucleoplasm cytoplasm cytosol learning or memory protein homodimerization activity negative regulation of neuron apoptotic process positive regulation of neurogenesis positive regulation of synapse assembly positive regulation of dendritic spine morphogenesis uc009uhw.1 uc009uhw.2 uc009uhw.3 
ENSMUST00000068767.10 Nlrp4a ENSMUST00000068767.10 NLR family, pyrin domain containing 4A, transcript variant 1 (from RefSeq NM_172896.4) ENSMUST00000068767.1 ENSMUST00000068767.2 ENSMUST00000068767.3 ENSMUST00000068767.4 ENSMUST00000068767.5 ENSMUST00000068767.6 ENSMUST00000068767.7 ENSMUST00000068767.8 ENSMUST00000068767.9 NAL4A_MOUSE NM_172896 Nalp4a Q8BU40 uc009ful.1 uc009ful.2 uc009ful.3 May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Belongs to the NLRP family. nucleotide binding molecular_function ATP binding cellular_component defense response inflammatory response uc009ful.1 uc009ful.2 uc009ful.3 
ENSMUST00000068792.13 Tmem245 ENSMUST00000068792.13 transmembrane protein 245, transcript variant 5 (from RefSeq NR_161228.1) B1AZA5 ENSMUST00000068792.1 ENSMUST00000068792.10 ENSMUST00000068792.11 ENSMUST00000068792.12 ENSMUST00000068792.2 ENSMUST00000068792.3 ENSMUST00000068792.4 ENSMUST00000068792.5 ENSMUST00000068792.6 ENSMUST00000068792.7 ENSMUST00000068792.8 ENSMUST00000068792.9 NR_161228 TM245_MOUSE uc029uuk.1 uc029uuk.2 uc029uuk.3 Membrane ; Multi-pass membrane protein Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family. membrane integral component of membrane uc029uuk.1 uc029uuk.2 uc029uuk.3 
ENSMUST00000068795.4 Mrfap1 ENSMUST00000068795.4 Morf4 family associated protein 1 (from RefSeq NM_026242.3) ENSMUST00000068795.1 ENSMUST00000068795.2 ENSMUST00000068795.3 MNCb-1039 MOFA1_MOUSE Mrfap1 NM_026242 Pam14 Q9CQL7 Q9CX68 uc008xfa.1 uc008xfa.2 uc008xfa.3 uc008xfa.4 Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2. Nucleus Cytoplasm, perinuclear region Note=Colocalizes with MORF4L1 to cell nuclei. Widely expressed in all tissues examined and as early as 7 days during embryonic development. Male mice are viable, fertile and show normal T- cell function. Belongs to the MORF4 family-associated protein family. Sequence=BAB31978.1; Type=Frameshift; Evidence=; protein binding nucleus cytoplasm cytosol biological_process perinuclear region of cytoplasm uc008xfa.1 uc008xfa.2 uc008xfa.3 uc008xfa.4 
ENSMUST00000068805.14 Eif2d ENSMUST00000068805.14 eukaryotic translation initiation factor 2D, transcript variant 10 (from RefSeq NM_001420324.1) EIF2D_MOUSE ENSMUST00000068805.1 ENSMUST00000068805.10 ENSMUST00000068805.11 ENSMUST00000068805.12 ENSMUST00000068805.13 ENSMUST00000068805.2 ENSMUST00000068805.3 ENSMUST00000068805.4 ENSMUST00000068805.5 ENSMUST00000068805.6 ENSMUST00000068805.7 ENSMUST00000068805.8 ENSMUST00000068805.9 Lgtn NM_001420324 Q3TDE0 Q3THV5 Q3TTP4 Q61211 Q8C491 Q8CBF1 Q8CC17 Q8R1I9 Q8R3M5 uc007cmz.1 uc007cmz.2 uc007cmz.3 uc007cmz.4 Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61211-1; Sequence=Displayed; Name=2; IsoId=Q61211-2; Sequence=VSP_016233; Belongs to the eIF2D family. Sequence=AAC53056.1; Type=Frameshift; Evidence=; formation of translation preinitiation complex RNA binding translation initiation factor activity cytoplasm cytosol translation translational initiation nuclear body cytosolic small ribosomal subunit ribosome disassembly IRES-dependent viral translational initiation uc007cmz.1 uc007cmz.2 uc007cmz.3 uc007cmz.4 
ENSMUST00000068813.3 Them7 ENSMUST00000068813.3 thioesterase superfamily member 7, transcript variant 1 (from RefSeq NM_028747.2) 0610012H03Rik ENSMUST00000068813.1 ENSMUST00000068813.2 NM_028747 Q9DCP4 Q9DCP4_MOUSE RP23-444H3.1 RP23-444H3.1-001 Them7 uc008lkq.1 uc008lkq.2 uc008lkq.3 uc008lkq.4 Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. mitochondrion biological_process acyl-CoA hydrolase activity uc008lkq.1 uc008lkq.2 uc008lkq.3 uc008lkq.4 
ENSMUST00000068825.8 Nub1 ENSMUST00000068825.8 negative regulator of ubiquitin-like proteins 1, transcript variant 2 (from RefSeq NM_016736.3) ENSMUST00000068825.1 ENSMUST00000068825.2 ENSMUST00000068825.3 ENSMUST00000068825.4 ENSMUST00000068825.5 ENSMUST00000068825.6 ENSMUST00000068825.7 NM_016736 Nub1 Q3UYM1 Q3UYM1_MOUSE uc008wsf.1 uc008wsf.2 uc008wsf.3 uc008wsf.4 uc008wsf.1 uc008wsf.2 uc008wsf.3 uc008wsf.4 
ENSMUST00000068853.13 Fat2 ENSMUST00000068853.13 Involved in the regulation of cell migration (By similarity). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity). (from UniProt Q5F226) AK173031 ENSMUST00000068853.1 ENSMUST00000068853.10 ENSMUST00000068853.11 ENSMUST00000068853.12 ENSMUST00000068853.2 ENSMUST00000068853.3 ENSMUST00000068853.4 ENSMUST00000068853.5 ENSMUST00000068853.6 ENSMUST00000068853.7 ENSMUST00000068853.8 ENSMUST00000068853.9 FAT2_MOUSE Fath2 Kiaa0811 Q3V1D4 Q5F226 Q69ZY7 uc287ygy.1 uc287ygy.2 Involved in the regulation of cell migration (By similarity). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity). Homodimer. Cell membrane ; Single-pass membrane protein Cell junction Golgi apparatus, trans-Golgi network Note=Localized at adhesion zippers (early state of adherens junctions) of keratinocytes. calcium ion binding Golgi apparatus plasma membrane cell-cell adherens junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules epithelial cell migration membrane integral component of membrane cell junction cell-substrate adhesion cell-cell adhesion uc287ygy.1 uc287ygy.2 
ENSMUST00000068856.5 Snupn ENSMUST00000068856.5 snurportin 1 (from RefSeq NM_178374.4) ENSMUST00000068856.1 ENSMUST00000068856.2 ENSMUST00000068856.3 ENSMUST00000068856.4 NM_178374 Q80W37 Rnut1 SPN1_MOUSE uc009ptr.1 uc009ptr.2 uc009ptr.3 Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts (via IBB domain) with KPNB1; the interaction is direct. Interacts with DDX20, IPO7, SMN1, SNRPB and XPO1. Interacts directly with XPO1. Its interaction with XPO1 and binding to m3G-cap U snRNPs appears to be mutually exclusive. Nucleus Cytoplasm Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta. It is re-exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway. Belongs to the snurportin family. molecular_function RNA binding nucleus cytoplasm protein import into nucleus snRNA import into nucleus nuclear import signal receptor activity uc009ptr.1 uc009ptr.2 uc009ptr.3 
ENSMUST00000068860.13 Epha6 ENSMUST00000068860.13 Eph receptor A6 (from RefSeq NM_007938.2) ENSMUST00000068860.1 ENSMUST00000068860.10 ENSMUST00000068860.11 ENSMUST00000068860.12 ENSMUST00000068860.2 ENSMUST00000068860.3 ENSMUST00000068860.4 ENSMUST00000068860.5 ENSMUST00000068860.6 ENSMUST00000068860.7 ENSMUST00000068860.8 ENSMUST00000068860.9 Epha6 G1K381 G1K381_MOUSE NM_007938 uc007zpo.1 uc007zpo.2 uc007zpo.3 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Membrane ; Single- pass type I membrane protein nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity ATP binding nucleoplasm protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation ephrin receptor signaling pathway uc007zpo.1 uc007zpo.2 uc007zpo.3 
ENSMUST00000068861.8 Cyp2d12 ENSMUST00000068861.8 cytochrome P450, family 2, subfamily d, polypeptide 12, transcript variant 1 (from RefSeq NM_201360.2) Cyp2d12 ENSMUST00000068861.1 ENSMUST00000068861.2 ENSMUST00000068861.3 ENSMUST00000068861.4 ENSMUST00000068861.5 ENSMUST00000068861.6 ENSMUST00000068861.7 NM_201360 Q8BVD2 Q8BVD2_MOUSE uc007wzh.1 uc007wzh.2 uc007wzh.3 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane Microsome membrane Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen arachidonic acid metabolic process heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc007wzh.1 uc007wzh.2 uc007wzh.3 
ENSMUST00000068875.5 Apobec4 ENSMUST00000068875.5 apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 4 (from RefSeq NM_001081197.1) ABEC4_MOUSE ENSMUST00000068875.1 ENSMUST00000068875.2 ENSMUST00000068875.3 ENSMUST00000068875.4 NM_001081197 Q497M3 uc007czi.1 uc007czi.2 Putative C to U editing enzyme whose physiological substrate is not yet known. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Predominantly expressed in testis. Belongs to the cytidine and deoxycytidylate deaminase family. Sequence=AAI00466.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; molecular_function cellular_component mRNA processing biological_process hydrolase activity metal ion binding uc007czi.1 uc007czi.2 
ENSMUST00000068877.7 Timd4 ENSMUST00000068877.7 T cell immunoglobulin and mucin domain containing 4 (from RefSeq NM_178759.4) ENSMUST00000068877.1 ENSMUST00000068877.2 ENSMUST00000068877.3 ENSMUST00000068877.4 ENSMUST00000068877.5 ENSMUST00000068877.6 NM_178759 Q6U7R3 Q6U7R4 Q8CIC7 TIMD4_MOUSE Tim4 uc007iox.1 uc007iox.2 uc007iox.3 Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation (PubMed:17960135). Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:18354194, PubMed:18367551). Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (By similarity). Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (PubMed:31263038). Homodimer. Q6U7R4; Q5QNS5: Havcr1; NbExp=4; IntAct=EBI-16764486, EBI-20217708; Q6U7R4; Q5QNS5-2: Havcr1; NbExp=2; IntAct=EBI-16764486, EBI-20217763; Membrane ; Single-pass type I membrane protein Predominantly expressed in lymphoid tissues, such as spleen, lymph nodes, and Peyer patches. Also expressed in fetal liver, salivary gland, and spleen stromal cells, predominantly in the marginal zone and to a lesser extent throughout the white pulp. Not expressed in bone marrow-derived cells. Expressed mainly by antigen presenting cells (APCs) in T- and B-cell areas, but not by T- or B- lymphocytes. Down-regulated in lymphotoxin deficient mice. Deletion mice maintained on methionine and choline-deficient diet exhibit significantly more obvious inflammation and severe lipid accumulation. Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma. Low expression of Timd4 is associated with lymphotoxin deficiency. Belongs to the immunoglobulin superfamily. TIM family. phosphatidylserine binding protein binding membrane integral component of membrane uc007iox.1 uc007iox.2 uc007iox.3 
ENSMUST00000068878.14 Ly9 ENSMUST00000068878.14 lymphocyte antigen 9, transcript variant 1 (from RefSeq NM_008534.4) ENSMUST00000068878.1 ENSMUST00000068878.10 ENSMUST00000068878.11 ENSMUST00000068878.12 ENSMUST00000068878.13 ENSMUST00000068878.2 ENSMUST00000068878.3 ENSMUST00000068878.4 ENSMUST00000068878.5 ENSMUST00000068878.6 ENSMUST00000068878.7 ENSMUST00000068878.8 ENSMUST00000068878.9 LY9_MOUSE Ly-9 NM_008534 Q01965 Q9ES29 Q9ES35 Q9ES36 uc007dou.1 uc007dou.2 uc007dou.3 uc007dou.4 Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922). May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T- cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter (By similarity). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T- cells (PubMed:23914190). May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (PubMed:23225888). Can promote natural killer (NK) cell activation (PubMed:19648922). Interacts with SH2D1A and INPP5D. Interacts (via phosphorylated cytoplasmic domain) with PTPN11; the interaction is blocked by SH2D1A. Membrane; Single-pass type I membrane protein. Cell membrane Lymphocytes. The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain- containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3). adaptive immune response immune system process plasma membrane cell adhesion cell surface membrane integral component of membrane positive regulation of interleukin-17 production innate immune response T-helper 17 cell lineage commitment uc007dou.1 uc007dou.2 uc007dou.3 uc007dou.4 
ENSMUST00000068891.12 Rnf144b ENSMUST00000068891.12 ring finger protein 144B, transcript variant 1 (from RefSeq NM_146042.4) ENSMUST00000068891.1 ENSMUST00000068891.10 ENSMUST00000068891.11 ENSMUST00000068891.2 ENSMUST00000068891.3 ENSMUST00000068891.4 ENSMUST00000068891.5 ENSMUST00000068891.6 ENSMUST00000068891.7 ENSMUST00000068891.8 ENSMUST00000068891.9 Ibrdc2 NM_146042 Q8BG97 Q8BKD6 Q8R195 R144B_MOUSE uc007qhx.1 uc007qhx.2 uc007qhx.3 uc007qhx.4 E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin- dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se (By similarity). Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence=; Protein modification; protein ubiquitination. Interacts with UBE2L3, UBE2L6 and LCMT2 as well as with BAX. Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation. Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT- type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain. Auto-ubiquitinated. Belongs to the RBR family. RNF144 subfamily. Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family. Sequence=AAH25007.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH25007.1; Type=Frameshift; Evidence=; ubiquitin ligase complex protein polyubiquitination ubiquitin-protein transferase activity cytoplasm mitochondrion ubiquitin-dependent protein catabolic process apoptotic process membrane integral component of membrane protein ubiquitination transferase activity ubiquitin conjugating enzyme binding mitochondrial membrane positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of apoptotic process metal ion binding ubiquitin protein ligase activity uc007qhx.1 uc007qhx.2 uc007qhx.3 uc007qhx.4 
ENSMUST00000068894.2 Capza1b ENSMUST00000068894.2 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (from UniProt Q9CR52) 4933400A11Rik AK015979 Capza1b ENSMUST00000068894.1 Q9CR52 Q9CR52_MOUSE uc012hrp.1 uc012hrp.2 uc012hrp.3 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Heterodimer of an alpha and a beta subunit. Belongs to the F-actin-capping protein alpha subunit family. actin binding F-actin capping protein complex actin cytoskeleton organization actin cortical patch actin filament binding barbed-end actin filament capping actin filament capping uc012hrp.1 uc012hrp.2 uc012hrp.3 
ENSMUST00000068904.9 Krt7 ENSMUST00000068904.9 keratin 7 (from RefSeq NM_033073.3) ENSMUST00000068904.1 ENSMUST00000068904.2 ENSMUST00000068904.3 ENSMUST00000068904.4 ENSMUST00000068904.5 ENSMUST00000068904.6 ENSMUST00000068904.7 ENSMUST00000068904.8 K2C7_MOUSE Krt2-7 Krt7 NM_033073 Q9DCV7 uc007xtd.1 uc007xtd.2 uc007xtd.3 uc007xtd.4 Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10. Interacts with GPER1 (By similarity). Expressed in most simple epithelia tested including liver, lactating mammary gland, lung, kidney, stomach, duodenum, colon, oviduct, uterus, pancreas, epididymis, prostate, preputial gland and mesothelium, and in most stratified epithelia tested including dorsal skin, paw/toe, tail, tongue, cervix, forestomach, and bladder. Also expressed in Henle layer of the inner root sheath of whisker follicle. Arg-15 is dimethylated, probably to asymmetric dimethylarginine. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. protein binding cytoplasm intermediate filament keratin filament uc007xtd.1 uc007xtd.2 uc007xtd.3 uc007xtd.4 
ENSMUST00000068911.13 Gabrg3 ENSMUST00000068911.13 gamma-aminobutyric acid type A receptor, subunit gamma 3 (from RefSeq NM_008074.3) ENSMUST00000068911.1 ENSMUST00000068911.10 ENSMUST00000068911.11 ENSMUST00000068911.12 ENSMUST00000068911.2 ENSMUST00000068911.3 ENSMUST00000068911.4 ENSMUST00000068911.5 ENSMUST00000068911.6 ENSMUST00000068911.7 ENSMUST00000068911.8 ENSMUST00000068911.9 G5E8E8 GBRG3_MOUSE NM_008074 P27681 uc009hdz.1 uc009hdz.2 uc009hdz.3 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. May be palmitoylated. This subunit carries the benzodiazepine binding site. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub- subfamily. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity inhibitory extracellular ligand-gated ion channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction gamma-aminobutyric acid signaling pathway chemical synaptic transmission membrane integral component of membrane GABA-gated chloride ion channel activity cell junction dendrite membrane ion transmembrane transport chloride channel complex regulation of membrane potential response to drug neuron projection synapse postsynaptic membrane neurological system process synaptic transmission, GABAergic regulation of postsynaptic membrane potential postsynapse GABA-ergic synapse chloride transmembrane transport GABA-A receptor complex transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential benzodiazepine receptor activity uc009hdz.1 uc009hdz.2 uc009hdz.3 
ENSMUST00000068916.16 Plpp5 ENSMUST00000068916.16 phospholipid phosphatase 5, transcript variant 1 (from RefSeq NM_028000.1) ENSMUST00000068916.1 ENSMUST00000068916.10 ENSMUST00000068916.11 ENSMUST00000068916.12 ENSMUST00000068916.13 ENSMUST00000068916.14 ENSMUST00000068916.15 ENSMUST00000068916.2 ENSMUST00000068916.3 ENSMUST00000068916.4 ENSMUST00000068916.5 ENSMUST00000068916.6 ENSMUST00000068916.7 ENSMUST00000068916.8 ENSMUST00000068916.9 NM_028000 PLPP5_MOUSE Plpp5 Q3UMZ3 Q4KL19 uc009lgr.1 uc009lgr.2 uc009lgr.3 Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules. Reaction=a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl- sn-glycero-3-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:27449, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608, ChEBI:CHEBI:59996; EC=3.6.1.75; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27450; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn- glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27430; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2- dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:42856, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:78229, ChEBI:CHEBI:82765; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42857; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctanoyl- sn-glycerol + phosphate; Xref=Rhea:RHEA:42860, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:76979, ChEBI:CHEBI:78229; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42861; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z- octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:39835, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:74544, ChEBI:CHEBI:75757; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39836; Evidence=; Magnesium-independent phospholipid phosphatase. Inhibited by N-ethylmaleimide. Lipid metabolism; phospholipid metabolism. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UMZ3-1; Sequence=Displayed; Name=2; IsoId=Q3UMZ3-2; Sequence=VSP_025243, VSP_025244; Specifically expressed by antibody-secreting immune cells. Mice lacking Plpp5 are viable and display no overt physical defect. Belongs to the PA-phosphatase related phosphoesterase family. integral component of plasma membrane phospholipid metabolic process phosphatidate phosphatase activity membrane integral component of membrane hydrolase activity phosphatase activity phospholipid dephosphorylation uc009lgr.1 uc009lgr.2 uc009lgr.3 
ENSMUST00000068944.9 Plekho2 ENSMUST00000068944.9 pleckstrin homology domain containing, family O member 2 (from RefSeq NM_153119.3) ENSMUST00000068944.1 ENSMUST00000068944.2 ENSMUST00000068944.3 ENSMUST00000068944.4 ENSMUST00000068944.5 ENSMUST00000068944.6 ENSMUST00000068944.7 ENSMUST00000068944.8 NM_153119 PKHO2_MOUSE Plekhq1 Q3TCY2 Q3U4R2 Q8C1F2 Q8K124 Q8R140 uc009qdn.1 uc009qdn.2 uc009qdn.3 uc009qdn.4 molecular_function cellular_component biological_process uc009qdn.1 uc009qdn.2 uc009qdn.3 uc009qdn.4 
ENSMUST00000068947.14 Acox3 ENSMUST00000068947.14 acyl-Coenzyme A oxidase 3, pristanoyl, transcript variant 1 (from RefSeq NM_030721.4) ACOX3_MOUSE ENSMUST00000068947.1 ENSMUST00000068947.10 ENSMUST00000068947.11 ENSMUST00000068947.12 ENSMUST00000068947.13 ENSMUST00000068947.2 ENSMUST00000068947.3 ENSMUST00000068947.4 ENSMUST00000068947.5 ENSMUST00000068947.6 ENSMUST00000068947.7 ENSMUST00000068947.8 ENSMUST00000068947.9 NM_030721 Q7TPP6 Q80UQ0 Q9EPL9 uc008xdx.1 uc008xdx.2 uc008xdx.3 Oxidizes the CoA-esters of 2-methyl-branched fatty acids. Reaction=a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2; Xref=Rhea:RHEA:38959, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:58856, ChEBI:CHEBI:65111; EC=1.3.3.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38960; Evidence=; Reaction=(2S)-pristanoyl-CoA + O2 = (2E)-pristenoyl-CoA + H2O2; Xref=Rhea:RHEA:40459, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:77099, ChEBI:CHEBI:77293; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40460; Evidence=; Reaction=O2 + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O2; Xref=Rhea:RHEA:40319, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:65052, ChEBI:CHEBI:74693; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40320; Evidence=; Reaction=hexadecanoyl-CoA + O2 = (2E)-hexadecenoyl-CoA + H2O2; Xref=Rhea:RHEA:40167, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57379, ChEBI:CHEBI:61526; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40168; Evidence=; Reaction=hexadecanedioyl-CoA + O2 = (2E)-hexadecenedioyl-CoA + H2O2; Xref=Rhea:RHEA:40275, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:77075, ChEBI:CHEBI:77085; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40276; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Lipid metabolism; peroxisomal fatty acid beta-oxidation. Peroxisome Belongs to the acyl-CoA oxidase family. acyl-CoA oxidase activity fatty acid binding mitochondrion peroxisome peroxisomal matrix lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation pristanoyl-CoA oxidase activity oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors fatty acid beta-oxidation using acyl-CoA oxidase flavin adenine dinucleotide binding lipid homeostasis oxidation-reduction process FAD binding uc008xdx.1 uc008xdx.2 uc008xdx.3 
ENSMUST00000068958.9 Cdc42ep3 ENSMUST00000068958.9 CDC42 effector protein 3 (from RefSeq NM_026514.3) BORG2_MOUSE Borg2 Cep3 ENSMUST00000068958.1 ENSMUST00000068958.2 ENSMUST00000068958.3 ENSMUST00000068958.4 ENSMUST00000068958.5 ENSMUST00000068958.6 ENSMUST00000068958.7 ENSMUST00000068958.8 NM_026514 Q3UD77 Q8BVR7 Q9CQC5 uc008dpx.1 uc008dpx.2 uc008dpx.3 Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts (By similarity). Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7. Endomembrane system ; Peripheral membrane protein Cytoplasm, cytoskeleton Belongs to the BORG/CEP family. Sequence=BAC36479.1; Type=Frameshift; Evidence=; protein binding cytoplasm cytoskeleton plasma membrane Rho protein signal transduction regulation of cell shape endomembrane system actin cytoskeleton membrane GTP-Rho binding positive regulation of actin filament polymerization positive regulation of pseudopodium assembly uc008dpx.1 uc008dpx.2 uc008dpx.3 
ENSMUST00000068968.12 4933427D06Rik ENSMUST00000068968.12 RIKEN cDNA 4933427D06 gene, transcript variant 2 (from RefSeq NR_134978.1) ENSMUST00000068968.1 ENSMUST00000068968.10 ENSMUST00000068968.11 ENSMUST00000068968.2 ENSMUST00000068968.3 ENSMUST00000068968.4 ENSMUST00000068968.5 ENSMUST00000068968.6 ENSMUST00000068968.7 ENSMUST00000068968.8 ENSMUST00000068968.9 NR_134978 uc291gwx.1 uc291gwx.2 uc291gwx.1 uc291gwx.2 
ENSMUST00000068975.6 Zfp180 ENSMUST00000068975.6 zinc finger protein 180, transcript variant 5 (from RefSeq NM_001289641.1) ENSMUST00000068975.1 ENSMUST00000068975.2 ENSMUST00000068975.3 ENSMUST00000068975.4 ENSMUST00000068975.5 NM_001289641 Q6NZI9 Q6NZI9_MOUSE Zfp180 uc009for.1 uc009for.2 uc009for.3 uc009for.4 uc009for.5 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc009for.1 uc009for.2 uc009for.3 uc009for.4 uc009for.5 
ENSMUST00000068996.13 9430038I01Rik ENSMUST00000068996.13 RIKEN cDNA 9430038I01 gene (from RefSeq NM_029886.2) CJ143_MOUSE ENSMUST00000068996.1 ENSMUST00000068996.10 ENSMUST00000068996.11 ENSMUST00000068996.12 ENSMUST00000068996.2 ENSMUST00000068996.3 ENSMUST00000068996.4 ENSMUST00000068996.5 ENSMUST00000068996.6 ENSMUST00000068996.7 ENSMUST00000068996.8 ENSMUST00000068996.9 NM_029886 Q9CX25 uc009ket.1 uc009ket.2 uc009ket.3 uc009ket.4 molecular_function cellular_component biological_process uc009ket.1 uc009ket.2 uc009ket.3 uc009ket.4 
ENSMUST00000068999.14 Micu3 ENSMUST00000068999.14 mitochondrial calcium uptake family, member 3 (from RefSeq NM_030110.2) ENSMUST00000068999.1 ENSMUST00000068999.10 ENSMUST00000068999.11 ENSMUST00000068999.12 ENSMUST00000068999.13 ENSMUST00000068999.2 ENSMUST00000068999.3 ENSMUST00000068999.4 ENSMUST00000068999.5 ENSMUST00000068999.6 ENSMUST00000068999.7 ENSMUST00000068999.8 ENSMUST00000068999.9 Efha2 MICU3_MOUSE NM_030110 Q9CTY5 uc009lmm.1 uc009lmm.2 uc009lmm.3 uc009lmm.4 May play a role in mitochondrial calcium uptake. Mitochondrion Membrane ; Single-pass membrane protein Predominantly expressed in skeletal muscle and central nervous system. Binds calcium. Belongs to the MICU1 family. MICU3 subfamily. Sequence=BAB31674.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; calcium ion binding cellular_component mitochondrion mitochondrial calcium ion transport biological_process membrane integral component of membrane metal ion binding uc009lmm.1 uc009lmm.2 uc009lmm.3 uc009lmm.4 
ENSMUST00000069004.14 Dcbld1 ENSMUST00000069004.14 discoidin, CUB and LCCL domain containing 1, transcript variant 1 (from RefSeq NM_025705.4) DCBD1_MOUSE ENSMUST00000069004.1 ENSMUST00000069004.10 ENSMUST00000069004.11 ENSMUST00000069004.12 ENSMUST00000069004.13 ENSMUST00000069004.2 ENSMUST00000069004.3 ENSMUST00000069004.4 ENSMUST00000069004.5 ENSMUST00000069004.6 ENSMUST00000069004.7 ENSMUST00000069004.8 ENSMUST00000069004.9 NM_025705 Q8R327 Q9D4J3 Q9D696 uc007fbd.1 uc007fbd.2 uc007fbd.3 uc007fbd.4 Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D4J3-1; Sequence=Displayed; Name=2; IsoId=Q9D4J3-2; Sequence=VSP_010783; Sequence=BAB29409.1; Type=Erroneous initiation; Evidence=; serine-type endopeptidase activity extracellular space membrane integral component of membrane zymogen activation uc007fbd.1 uc007fbd.2 uc007fbd.3 uc007fbd.4 
ENSMUST00000069009.7 Maf ENSMUST00000069009.7 Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters (By similarity). Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta- crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding. (from UniProt P54843) AK132165 ENSMUST00000069009.1 ENSMUST00000069009.2 ENSMUST00000069009.3 ENSMUST00000069009.4 ENSMUST00000069009.5 ENSMUST00000069009.6 MAF_MOUSE Maf2 P54843 Q3V1Z2 Q4QY62 uc009noe.1 uc009noe.2 uc009noe.3 uc009noe.4 Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters (By similarity). Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta- crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding. Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or as a heterodimer. Heterotetramer of two MAF and two USF2. Interacts with PAX6; the interaction is direct. Interacts with MYB; interaction takes place weakly in normal T- cells and increases in T-cells following stimulation through the TCR engagement. Interacts with MYB; the ternary complex formed with MYB and the CD13 promoter is regulated in response to differentiating signals. Interacts with USF2; the interaction inhibits its DNA-binding activity on the L7 promoter. Interacts with CREBBP, EP300 and ETS1 (By similarity). P54843; Q91ZW3: Smarca5; NbExp=2; IntAct=EBI-3842521, EBI-927547; Nucleus. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P54843-1; Sequence=Displayed; Name=2; Synonyms=Long; IsoId=P54843-2; Sequence=VSP_036408; Name=3; IsoId=P54843-3; Sequence=VSP_036409; Expressed in tubules of the renal cortex and hepatocytes. Expressed in the lens (at protein level). Expressed in pancreatic islets and endothelial cells. Expressed in the floor of the diencephalon at 10 dpc (at protein level). Expressed in the midline of the forebrain and in the eye region at 9 dpc. Expressed in the head ectoderm destined to become the lens vesicle at 9 and 10 dpc. Expressed in the lens placode at 10.5 dpc. Expressed in the lens vesicle in both epithelial and fiber cells at 11 dpc. Expressed in secondary fiber cells at the equatorial region that divides the lens into anterior and posterior hemispheres between 11 and 14 dpc. Expressed in the neural tube and in primary fiber cells of the lens at 11.5 dpc. Expressed in proximal tubules of the cortex in the kidney at 16 and 17 dpc. Expressed in hypertrophic chondrocytes at 14.5 to 18.5 dpc. Expressed in the pancreas at 12.5 dpc until the adult stage. Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by glucocorticoids (By similarity). Phosphorylated by GSK3 and MAPK13 on serine and threonine residues (By similarity). The phosphorylation status can serve to either stimulate or inhibit transcription. Knockout mice lacking this gene exhibit small eyes or microphthalmia with an absence of normal lens structures, an abnormal chondrocyte development, with terminal differentiation of hypertrophic chondrocytes initially delayed, followed by a subsequent expansion of the hypertrophic chondrocyte domain in the growth plates of embryonic and postnatal long bones. They also show a lack of IL4 production. Belongs to the bZIP family. Maf subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cytokine production lens development in camera-type eye DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated positive regulation of gene expression regulation of chondrocyte differentiation protein homodimerization activity sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity cell development inner ear development lens fiber cell differentiation uc009noe.1 uc009noe.2 uc009noe.3 uc009noe.4 
ENSMUST00000069023.4 Tcaf3 ENSMUST00000069023.4 TRPM8 channel-associated factor 3 (from RefSeq NM_203396.1) ENSMUST00000069023.1 ENSMUST00000069023.2 ENSMUST00000069023.3 Eapa2 Fam115e NM_203396 Q6QR59 TCAF3_MOUSE Tcaf3 uc009brm.1 uc009brm.2 May play a role in the regulation of the cation channel TRPM8 activity. Prostate-specific. Present in both dorso-lateral and anterior prostate. May act as an autoantigen in prostate autoimmunity. Belongs to the TCAF family. protein binding plasma membrane negative regulation of anion channel activity ion channel binding positive regulation of protein targeting to membrane uc009brm.1 uc009brm.2 
ENSMUST00000069035.6 A630091E08Rik ENSMUST00000069035.6 A630091E08Rik (from geneSymbol) AK080393 ENSMUST00000069035.1 ENSMUST00000069035.2 ENSMUST00000069035.3 ENSMUST00000069035.4 ENSMUST00000069035.5 uc009ikm.1 uc009ikm.2 uc009ikm.3 uc009ikm.1 uc009ikm.2 uc009ikm.3 
ENSMUST00000069041.15 Ap1s2 ENSMUST00000069041.15 adaptor-related protein complex 1, sigma 2 subunit, transcript variant 3 (from RefSeq NM_001290379.1) AP1S2_MOUSE B1B0F4 ENSMUST00000069041.1 ENSMUST00000069041.10 ENSMUST00000069041.11 ENSMUST00000069041.12 ENSMUST00000069041.13 ENSMUST00000069041.14 ENSMUST00000069041.2 ENSMUST00000069041.3 ENSMUST00000069041.4 ENSMUST00000069041.5 ENSMUST00000069041.6 ENSMUST00000069041.7 ENSMUST00000069041.8 ENSMUST00000069041.9 NM_001290379 Q543R7 Q9DB50 uc009uuy.1 uc009uuy.2 uc009uuy.3 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity). Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds to MUC1 (By similarity). Golgi apparatus. Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane, clathrin-coated pit Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Widely expressed. Belongs to the adaptor complexes small subunit family. protein binding Golgi apparatus clathrin-coated pit intracellular protein transport visual learning protein transport membrane synaptic vesicle budding from endosome vesicle-mediated transport membrane coat cytoplasmic vesicle membrane cytoplasmic vesicle synaptic vesicle recycling intracellular membrane-bounded organelle synapse fat cell differentiation neuromuscular process controlling balance adipose tissue development presynapse uc009uuy.1 uc009uuy.2 uc009uuy.3 
ENSMUST00000069051.2 Gm9972 ENSMUST00000069051.2 Gm9972 (from geneSymbol) ENSMUST00000069051.1 uc287xmn.1 uc287xmn.2 uc287xmn.1 uc287xmn.2 
ENSMUST00000069064.7 Ydjc ENSMUST00000069064.7 YdjC homolog (bacterial), transcript variant 1 (from RefSeq NM_026940.4) ENSMUST00000069064.1 ENSMUST00000069064.2 ENSMUST00000069064.3 ENSMUST00000069064.4 ENSMUST00000069064.5 ENSMUST00000069064.6 NM_026940 Q14BV6 Q8C5Z5 Q9D8Z7 YDJC_MOUSE uc007ykj.1 uc007ykj.2 uc007ykj.3 uc007ykj.4 Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14BV6-1; Sequence=Displayed; Name=2; IsoId=Q14BV6-2; Sequence=VSP_032788; Belongs to the YdjC deacetylase family. Sequence=BAC36514.1; Type=Frameshift; Evidence=; magnesium ion binding catalytic activity cellular_component carbohydrate metabolic process biological_process hydrolase activity deacetylase activity metal ion binding uc007ykj.1 uc007ykj.2 uc007ykj.3 uc007ykj.4 
ENSMUST00000069066.14 Cyria ENSMUST00000069066.14 CYFIP related Rac1 interactor A, transcript variant 1 (from RefSeq NM_029758.5) CYRIA_MOUSE D12Ertd553e ENSMUST00000069066.1 ENSMUST00000069066.10 ENSMUST00000069066.11 ENSMUST00000069066.12 ENSMUST00000069066.13 ENSMUST00000069066.2 ENSMUST00000069066.3 ENSMUST00000069066.4 ENSMUST00000069066.5 ENSMUST00000069066.6 ENSMUST00000069066.7 ENSMUST00000069066.8 ENSMUST00000069066.9 Fam49a NM_029758 Q8BHZ0 uc007nbc.1 uc007nbc.2 uc007nbc.3 uc007nbc.4 uc007nbc.5 May negatively regulate RAC1 signaling and RAC1-driven cytoskeletal remodeling. May regulate chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Interacts with RAC1 (GTP-bound form preferentially). Membrane ; Lipid- anchor Belongs to the CYRI family. molecular_function biological_process uc007nbc.1 uc007nbc.2 uc007nbc.3 uc007nbc.4 uc007nbc.5 
ENSMUST00000069097.13 Ago3 ENSMUST00000069097.13 argonaute RISC catalytic subunit 3 (from RefSeq NM_153402.2) AGO3_MOUSE ENSMUST00000069097.1 ENSMUST00000069097.10 ENSMUST00000069097.11 ENSMUST00000069097.12 ENSMUST00000069097.2 ENSMUST00000069097.3 ENSMUST00000069097.4 ENSMUST00000069097.5 ENSMUST00000069097.6 ENSMUST00000069097.7 ENSMUST00000069097.8 ENSMUST00000069097.9 Eif2c3 NM_153402 Q3TBP7 Q8CJF9 uc008uth.1 uc008uth.2 uc008uth.3 uc008uth.4 Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA- dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4 (PubMed:19174539). Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide- target complementarity (By similarity). Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.n2; Evidence=; Interacts with EIF4B, IMP8, PRMT5 and TNRC6B (By similarity). Interacts with APOBEC3F, APOBEC3G and APOBEC3H. Interacts with EDC4 (By similarity). Cytoplasm, P-body Ubiquitinated on surface-exposed lysines by a SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 during target- directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). Ubiquitination by the SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 leads to its subsequent degradation, thereby exposing miRNAs for degradation. ZSWIM8 recognizes and binds AGO3 when it is engaged with a TDMD target. Belongs to the argonaute family. Ago subfamily. condensed nuclear chromosome P-body nucleic acid binding RNA binding double-stranded RNA binding single-stranded RNA binding nuclease activity endonuclease activity endoribonuclease activity nucleoplasm cytoplasm mRNA catabolic process regulation of translation RNA secondary structure unwinding positive regulation of gene expression RISC complex hydrolase activity gene silencing by RNA pre-miRNA processing production of miRNAs involved in gene silencing by miRNA miRNA binding miRNA mediated inhibition of translation mRNA cleavage involved in gene silencing by miRNA miRNA loading onto RISC involved in gene silencing by miRNA cytoplasmic ribonucleoprotein granule metal ion binding RISC-loading complex regulation of stem cell proliferation nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic endoribonuclease activity, cleaving miRNA-paired mRNA positive regulation of NIK/NF-kappaB signaling uc008uth.1 uc008uth.2 uc008uth.3 uc008uth.4 
ENSMUST00000069098.7 Mtcl2 ENSMUST00000069098.7 microtubule crosslinking factor 2 (from RefSeq NM_001164663.1) A2ACV6 E1U8D0 ENSMUST00000069098.1 ENSMUST00000069098.2 ENSMUST00000069098.3 ENSMUST00000069098.4 ENSMUST00000069098.5 ENSMUST00000069098.6 MTCL2_MOUSE NM_001164663 Soga Soga1 uc008nol.1 uc008nol.2 uc008nol.3 uc008nol.4 Microtubule-associated factor that enables integration of the centrosomal and Golgi-associated microtubules on the Golgi membrane, supporting directional migration. Preferentially acts on the perinuclear microtubules accumulated around the Golgi. Associates with the Golgi membrane through the N-terminal coiled-coil region and directly binds microtubules through the C-terminal domain (PubMed:35543016). Required for faithful chromosome segregation during mitosis (By similarity). Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin- dependent manner (PubMed:20813965). Interacts with CLASP2 (PubMed:28550165). Interacts with CLASP1 (By similarity). The C-terminal SOGA 25 kDa form occurs as a monomer (PubMed:20813965). [C-terminal 80 kDa form]: Secreted Note=Secreted in primary hepatocyte- conditioned media. Cytoplasm, cytoskeleton Golgi apparatus membrane Midbody Note=Co-localizes with CLASP2 in microtubules. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E1U8D0-1; Sequence=Displayed; Name=2; IsoId=E1U8D0-2; Sequence=VSP_062227; Expressed in liver (at protein level). Up-regulated by adiponectin in primary hepatocytes through the insulin signaling pathway. Down-regulated by amino-imidazole carboxamide riboside (AICAR), an AMPK activator that potentiated insulin secretion. Associates with the Golgi membrane through the N-terminal coiled-coil region and directly binds microtubules through the C- terminal domain. Proteolytically cleaved into a C-terminal SOGA 25 kDa form that is detected in plasma (By similarity). Proteolytically cleaved in primary hepatocytes into a C-terminal SOGA 80 kDa form. Phosphorylated during mitosis in a CDK1-dependent manner. Belongs to the MTCL family. Sequence=ADC34694.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=DAA34787.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function extracellular region extracellular space insulin receptor signaling pathway regulation of autophagy negative regulation of gluconeogenesis uc008nol.1 uc008nol.2 uc008nol.3 uc008nol.4 
ENSMUST00000069103.11 Xlr4b ENSMUST00000069103.11 X-linked lymphocyte-regulated 4B, transcript variant 1 (from RefSeq NM_021365.3) ENSMUST00000069103.1 ENSMUST00000069103.10 ENSMUST00000069103.2 ENSMUST00000069103.3 ENSMUST00000069103.4 ENSMUST00000069103.5 ENSMUST00000069103.6 ENSMUST00000069103.7 ENSMUST00000069103.8 ENSMUST00000069103.9 NM_021365 Q9JJQ7 Q9JJQ7_MOUSE Xlr4 Xlr4b Xlr4e uc009tlj.1 uc009tlj.2 uc009tlj.3 uc009tlj.4 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle positive regulation of synapse assembly positive regulation of dendritic spine morphogenesis uc009tlj.1 uc009tlj.2 uc009tlj.3 uc009tlj.4 
ENSMUST00000069106.5 Epm2a ENSMUST00000069106.5 epilepsy, progressive myoclonic epilepsy, type 2 gene alpha (from RefSeq NM_010146.2) ENSMUST00000069106.1 ENSMUST00000069106.2 ENSMUST00000069106.3 ENSMUST00000069106.4 EPM2A_MOUSE G5E8E2 NM_010146 Q8BY80 Q9WUA5 uc007ejv.1 uc007ejv.2 uc007ejv.3 Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin (PubMed:18040046, PubMed:18852261, PubMed:19036738, PubMed:23663739, PubMed:24430976, PubMed:24068615). Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:16971387, PubMed:24430976). Has also been shown to dephosphorylate MAPT (PubMed:19542233). Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:18040046, PubMed:18852261, PubMed:23663739). Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS) (PubMed:19036738, PubMed:24068615). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway (PubMed:20453062). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Homodimer (PubMed:16971387). Interacts with PPP1R3B, PPP1R3C, HIRIP5, and EPM2AIP1 (By similarity). Binds glycogen and Lafora bodies. Interacts with NHLRC1/malin (via the NHL repeats) (By similarity). Forms a complex with NHLRC1/malin and HSP70 (PubMed:19036738). Interacts with PPP1R3D; in the presence of NHLC1/malin the interaction leads to ubiquitination and autophagic degradation of PPP1R3D (PubMed:23624058). Interacts (via the phosphatase domain) with MAPT/Tau; the interaction dephosphorylates MAPT (PubMed:19542233). Interacts with PRDM8 (By similarity). Q9WUA5; Q9WV60: Gsk3b; NbExp=2; IntAct=EBI-1040928, EBI-400793; Q9WUA5; Q6VVB1: NHLRC1; Xeno; NbExp=12; IntAct=EBI-1040928, EBI-6426628; Cytoplasm Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane Note=Colocalizes with glycogen synthase in punctate structures in the cytoplasm. Primarily associated with polyribosomes at the rough endoplasmic reticulum, and also detected at the plasma membrane. Under glycogenolytic conditions localizes to the nucleus. Detected in skeletal muscle and in brain (at protein level) (PubMed:24430976). Widely expressed. Higher levels of expression are found in heart, brain, liver, skeletal muscle and kidney (PubMed:10092504). In the embryo, highly expressed at 17 dpc. Detected in all postnatal stages, but highest expression is found at day 160 after birth. The CBM20 domain mediates binding to cytoplasmic glycogen and to Lafora polyglucosan bodies. Polyubiquitinated by NHLRC1/malin. Phosphorylation on Ser-25 by AMPK affects the phosphatase activity of the enzyme and its ability to homodimerize and interact with NHLRC1, PPP1R3C or PRKAA2. Impaired behavioral responses, ataxia, spontaneous myoclonic seizures and progressive accumulation of poorly- branched, insoluble forms of glycogen (Lafora bodies) in liver, brain and skeletal muscle tissue (PubMed:12019206, PubMed:18040046, PubMed:24430976). Expression of both wild-type Epm2a and mutated Epm2a without phosphatase activity can abolish the appearance of Lafora bodies in brain and heart from 7 to over 12 month old mutant mice (PubMed:24430976). At 3 months of age, overall glycogen levels are normal; by 9 months of age, a 3-fold increase in overall glycogen levels and a 6-fold increase in glycogen phosphate levels is observed (PubMed:18040046, PubMed:18852261, PubMed:22669944, PubMed:23663739). Muscle glycogen has an altered structure, with a reduced size, an abnormally high proportion of very short side chains, fewer medium- length chains and an increased number of long chains (PubMed:23663739). Glycogen synthase (Gys1) and 1,4-alpha-glucan-branching enzyme (Gbe1) activities in brain and muscle tissue are normal (PubMed:18040046). 10 month old mice have neurofibrillary tangles (NFTs, aggregates of hyperphosphorylated Mapt/Tau) in brain and muscle tissue, however NFTs are not observed in 4 and 6 month old mice (PubMed:19542233). 3- and 12- month old mice show reduced numbers of autophagosomes in liver extracts, and 3-month old starved mice have increased levels of the autophagy dysfunction marker Map1lc3b/LC3-II and increased levels of ubiquitinated proteins, suggesting impaired macroautophagy (PubMed:20453062). Belongs to the protein-tyrosine phosphatase family. autophagosome assembly regulation of cell growth regulation of protein phosphorylation glycogen (starch) synthase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein binding nucleus nucleoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol polysome plasma membrane carbohydrate metabolic process glycogen metabolic process glycogen biosynthetic process protein dephosphorylation calcium ion transport autophagy mitochondrion organization nervous system development protein tyrosine/serine/threonine phosphatase activity regulation of gene expression negative regulation of gene expression negative regulation of phosphatase activity glial cell proliferation L-glutamate transport membrane Wnt signaling pathway positive regulation of macroautophagy dephosphorylation hydrolase activity phosphatase activity carbohydrate phosphatase activity carbohydrate binding polysaccharide binding dendrite regulation of protein ubiquitination negative regulation of TOR signaling negative regulation of peptidyl-serine phosphorylation negative regulation of dephosphorylation peptidyl-tyrosine dephosphorylation regulation of protein import into nucleus regulation of phosphorylation identical protein binding protein homodimerization activity proteasome-mediated ubiquitin-dependent protein catabolic process perikaryon cellular macromolecule metabolic process negative regulation of cell cycle regulation of protein kinase activity carbohydrate phosphorylation phosphorylated carbohydrate dephosphorylation habituation protein dimerization activity regulation of proteasomal protein catabolic process cytoplasmic side of endoplasmic reticulum membrane cytoplasmic side of rough endoplasmic reticulum membrane regulation of protein localization to plasma membrane regulation of ubiquitin protein ligase activity regulation of glycogen (starch) synthase activity glycogen binding starch binding uc007ejv.1 uc007ejv.2 uc007ejv.3 
ENSMUST00000069107.14 Mapk1 ENSMUST00000069107.14 mitogen-activated protein kinase 1, transcript variant 1 (from RefSeq NM_011949.3) ENSMUST00000069107.1 ENSMUST00000069107.10 ENSMUST00000069107.11 ENSMUST00000069107.12 ENSMUST00000069107.13 ENSMUST00000069107.2 ENSMUST00000069107.3 ENSMUST00000069107.4 ENSMUST00000069107.5 ENSMUST00000069107.6 ENSMUST00000069107.7 ENSMUST00000069107.8 ENSMUST00000069107.9 Erk2 MK01_MOUSE Mapk Mapk1 NM_011949 P27703 P63085 Prkm1 Q3V1U6 uc007yjr.1 uc007yjr.2 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1 and FXR1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-183 and Tyr-185 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Phosphorylation on Ser-27 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Dephosphorylated and inactivated by DUSP1, DUSP3, DUSP6 and DUSP9. Inactivated by pyrimidylpyrrole inhibitors. Binds both upstream activators and downstream substrates in multimolecular complexes. This interaction inhibits its tyrosine-kinase activity. Interacts with ADAM15, ARHGEF2, ARRB2, DAPK1 (via death domain), HSF4, IER3, IPO7, NISCH, SGK1, and isoform 1 of NEK2. Interacts (via phosphorylated form) with TPR (via C-terminal region and phosphorylated form); the interaction requires dimerization of MAPK1/ERK2 and increases following EGF stimulation (By similarity). Interacts with MAP2K1 (By similarity). Interacts with DUSP6 (By similarity). Interacts (phosphorylated form) with CAV2 ('Tyr-19'- phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with DCC (By similarity). Interacts with MORG1 (PubMed:15118098). Interacts with PEA15 (PubMed:16162500). Interacts with MKNK2. MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (PubMed:11702783). The phosphorylated form interacts with PML. Interacts with STYX. Interacts with CDK2AP2. Interacts with CAVIN4 (By similarity). Interacts with DUSP7; the interaction enhances DUSP7 phosphatase activity (PubMed:27783954). Interacts with GIT1; this interaction is necessary for MAPK1 localization to focal adhesions (PubMed:15923189). Interacts with ZNF263 (By similarity). P63085; Q62108: Dlg4; NbExp=4; IntAct=EBI-397697, EBI-300895; P63085; Q9DBB1: Dusp6; NbExp=2; IntAct=EBI-397697, EBI-7812384; P63085; Q03172: Hivep1; NbExp=4; IntAct=EBI-397697, EBI-646850; P63085; P63085: Mapk1; NbExp=5; IntAct=EBI-397697, EBI-397697; P63085; Q8CDB0: Mknk2; NbExp=23; IntAct=EBI-397697, EBI-646209; P63085; Q8R332-1: Nup58; NbExp=3; IntAct=EBI-397697, EBI-646962; P63085; Q62132: Ptprr; NbExp=5; IntAct=EBI-397697, EBI-6954051; P63085; Q9Z2B9: Rps6ka4; NbExp=3; IntAct=EBI-397697, EBI-412887; P63085; P49841: GSK3B; Xeno; NbExp=2; IntAct=EBI-397697, EBI-373586; P63085; O95863: SNAI1; Xeno; NbExp=3; IntAct=EBI-397697, EBI-1045459; P63085; A0A0F6AZL3: sseI; Xeno; NbExp=3; IntAct=EBI-397697, EBI-16463657; P63085; G3G926: US2; Xeno; NbExp=8; IntAct=EBI-397697, EBI-11692733; Cytoplasm, cytoskeleton, spindle Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm. Membrane, caveola Cell junction, focal adhesion Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser-244 and Ser-246 as well as autophosphorylation at Thr-188 promote nuclear localization (By similarity). Localization to focal adhesions is stimulated by EGF (PubMed:15923189). Widely expressed. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation (By similarity). Dephosphorylated by PTPRJ at Tyr-185 (By similarity). Phosphorylated upon FLT3 and KIT signaling (By similarity). Dephosphorylated by DUSP1 and DUSP2 at Thr-183 and Tyr-185 (By similarity) (PubMed:8221888). ISGylated. Ubiquitinated by TRIM15 via 'Lys-63'-linked ubiquitination; leading to activation. Deubiquitinated by CYLD. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. MAPK cascade nucleotide binding activation of MAPK activity phosphotyrosine binding double-stranded DNA binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity MAP kinase kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm mitochondrion early endosome late endosome Golgi apparatus microtubule organizing center spindle cytosol cytoskeleton plasma membrane caveola focal adhesion transcription, DNA-templated protein phosphorylation apoptotic process cellular response to DNA damage stimulus cell cycle signal transduction heart development aging transcription factor binding positive regulation of cell proliferation RNA polymerase II carboxy-terminal domain kinase activity response to toxic substance animal organ morphogenesis regulation of gene expression positive regulation of gene expression positive regulation of peptidyl-threonine phosphorylation neural crest cell development postsynaptic density diadenosine tetraphosphate biosynthetic process membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation sensory perception of pain cytosine metabolic process protein kinase binding phosphatase binding regulation of ossification positive regulation of cell migration axon regulation of cellular pH thyroid gland development pseudopodium mitogen-activated protein kinase kinase kinase binding regulation of protein stability lipopolysaccharide-mediated signaling pathway positive regulation of telomere maintenance via telomerase response to lipopolysaccharide dendrite cytoplasm regulation of stress-activated MAPK cascade macromolecular complex mammary gland epithelial cell proliferation cellular response to amino acid starvation cellular response to reactive oxygen species response to nicotine intracellular signal transduction ERBB signaling pathway positive regulation of protein import into nucleus outer ear morphogenesis identical protein binding perikaryon response to exogenous dsRNA response to estrogen negative regulation of cell differentiation positive regulation of translation positive regulation of transcription, DNA-templated decidualization thymus development T cell receptor signaling pathway B cell receptor signaling pathway regulation of sequence-specific DNA binding transcription factor activity stress-activated MAPK cascade regulation of cytoskeleton organization positive regulation of telomerase activity Bergmann glial cell differentiation positive regulation of cardiac muscle cell proliferation long-term synaptic potentiation face development lung morphogenesis trachea formation labyrinthine layer blood vessel development cardiac neural crest cell development involved in heart development ERK1 and ERK2 cascade response to epidermal growth factor cellular response to cadmium ion cellular response to organic substance cellular response to tumor necrosis factor caveolin-mediated endocytosis mitotic spindle regulation of Golgi inheritance cellular response to granulocyte macrophage colony-stimulating factor stimulus cellular response to dopamine positive regulation of telomere capping regulation of early endosome to late endosome transport uc007yjr.1 uc007yjr.2 
ENSMUST00000069125.8 Calhm5 ENSMUST00000069125.8 calcium homeostasis modulator family member 5 (from RefSeq NM_178908.3) CAHM5_MOUSE ENSMUST00000069125.1 ENSMUST00000069125.2 ENSMUST00000069125.3 ENSMUST00000069125.4 ENSMUST00000069125.5 ENSMUST00000069125.6 ENSMUST00000069125.7 Fam26e NM_178908 Q8C3G8 Q8R100 uc007euq.1 uc007euq.2 uc007euq.3 Pore-forming subunit of a voltage-gated ion channel. Membrane ; Multi-pass membrane protein Belongs to the CALHM family. Sequence=BAC39570.1; Type=Frameshift; Evidence=; integral component of plasma membrane ion transport membrane integral component of membrane uc007euq.1 uc007euq.2 uc007euq.3 
ENSMUST00000069142.12 Akr1cl ENSMUST00000069142.12 aldo-keto reductase family 1, member C-like, transcript variant 1 (from RefSeq NM_027582.4) Akr1cl ENSMUST00000069142.1 ENSMUST00000069142.10 ENSMUST00000069142.11 ENSMUST00000069142.2 ENSMUST00000069142.3 ENSMUST00000069142.4 ENSMUST00000069142.5 ENSMUST00000069142.6 ENSMUST00000069142.7 ENSMUST00000069142.8 ENSMUST00000069142.9 NM_027582 Q3UXL1 Q3UXL1_MOUSE uc007bhc.1 uc007bhc.2 uc007bhc.3 uc007bhc.4 Belongs to the aldo/keto reductase family. alditol:NADP+ 1-oxidoreductase activity aldo-keto reductase (NADP) activity cytoplasm cytosol alcohol dehydrogenase (NADP+) activity steroid metabolic process steroid dehydrogenase activity oxidoreductase activity ketosteroid monooxygenase activity oxidation-reduction process uc007bhc.1 uc007bhc.2 uc007bhc.3 uc007bhc.4 
ENSMUST00000069168.13 Cpsf6 ENSMUST00000069168.13 cleavage and polyadenylation specific factor 6, transcript variant 2 (from RefSeq NM_001013391.2) CPSF6_MOUSE Cpsf6 ENSMUST00000069168.1 ENSMUST00000069168.10 ENSMUST00000069168.11 ENSMUST00000069168.12 ENSMUST00000069168.2 ENSMUST00000069168.3 ENSMUST00000069168.4 ENSMUST00000069168.5 ENSMUST00000069168.6 ENSMUST00000069168.7 ENSMUST00000069168.8 ENSMUST00000069168.9 NM_001013391 Q6NVF9 Q8BX86 Q8BXI8 uc007hdd.1 uc007hdd.2 uc007hdd.3 uc007hdd.4 Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA- 3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export. Component of the cleavage factor Im (CFIm) complex which is a heterotetramer composed of two subunits of NUDT21/CPSF5 and two subunits of CPSF6 or CPSF7 or a heterodimer of CPSF6 and CPSF7. The cleavage factor Im (CFIm) complex associates with the CPSF and CSTF complexes to promote the assembly of the core mRNA 3'-processing machinery. Associates with the exon junction complex (EJC). Associates with the 80S ribosome particle. Interacts (via the RRM domain) with NUDT21/CPSF5; this interaction is direct and enhances binding to RNA. Interacts (via Arg/Ser-rich domain) with FIP1L1 (preferentially via unphosphorylated form and Arg/Glu/Asp-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF6 hyper-phosphorylation. Interacts (via N-terminus) with NXF1; this interaction is direct. Interacts with SRSF3. Interacts with SRSF7. Interacts with SNRNP70. Interacts with TRA2B/SFRS10. Interacts with UPF1. Interacts with UPF3B. Interacts with VIRMA. Interacts (via Arg/Ser-rich domain) with TNPO3; promoting nuclear import of CPSF6 independently of its phosphorylation status (By similarity). Interacts with YTHDC1 (PubMed:29799838). Nucleus Nucleus, nucleoplasm Nucleus speckle Cytoplasm Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm). Colocalizes with PSPC1 in punctate subnuclear structures often located adjacent to nuclear speckles, called paraspeckles, and corresponding to interchromatin granules-associated zones (IGAZs). Distribution in speckles and paraspeckles varies during the cell cycle. Associates at sites of active transcription on nascent perichromatin fibrils (PFs) and perichromatin granules. Nuclear import is mediated via interaction with TNPO3 independently of CPSF6 phosphorylation status. Expressed in testis (PubMed:18032416). Expressed in male germ cells (at protein level) (PubMed:18032416). Up-regulated during spermatogenesis (PubMed:18032416). Contains an Arg/Ser-rich domain composed of arginine-serine dipeptide repeats within the C-terminal region that is necessary and sufficient for activating mRNA 3'-processing and alternative polyadenylation (APA). Phosphorylated. Phosphorylated in the Arg/Ser-rich domain by SRPK1, in vitro. Symmetrically dimethylated on arginine residues by PRMT5 in a WDR77- and CLNS1A-dependent manner. Asymmetrically dimethylated on arginine residues by PRMT1. Symmetrically dimethylated on arginine residues in the GAR motif by PRMT5 in a WDR77- and CLNS1A-dependent manner. Asymmetrically dimethylated on arginine residues in the GAR motif by PRMT1. Belongs to the RRM CPSF6/7 family. nucleic acid binding RNA binding mRNA binding nucleus nucleoplasm perichromatin fibrils cytoplasm mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex mRNA processing nuclear speck interchromatin granule paraspeckles ribosomal large subunit binding positive regulation of RNA export from nucleus protein tetramerization protein heterotetramerization pre-mRNA cleavage required for polyadenylation messenger ribonucleoprotein complex assembly exon-exon junction complex binding ribonucleoprotein complex uc007hdd.1 uc007hdd.2 uc007hdd.3 uc007hdd.4 
ENSMUST00000069180.8 Zcchc24 ENSMUST00000069180.8 zinc finger, CCHC domain containing 24 (from RefSeq NM_001101433.2) B2RVL6 ENSMUST00000069180.1 ENSMUST00000069180.2 ENSMUST00000069180.3 ENSMUST00000069180.4 ENSMUST00000069180.5 ENSMUST00000069180.6 ENSMUST00000069180.7 NM_001101433 ZCH24_MOUSE Zcchc24 uc011zho.1 uc011zho.2 uc011zho.3 nucleic acid binding cellular_component zinc ion binding metal ion binding uc011zho.1 uc011zho.2 uc011zho.3 
ENSMUST00000069183.8 Gucy2g ENSMUST00000069183.8 guanylate cyclase 2g, transcript variant 1 (from RefSeq NM_001081076.3) ENSMUST00000069183.1 ENSMUST00000069183.2 ENSMUST00000069183.3 ENSMUST00000069183.4 ENSMUST00000069183.5 ENSMUST00000069183.6 ENSMUST00000069183.7 GUC2G_MOUSE NM_001081076 Q6TL19 Q8BWU7 uc008hxo.1 uc008hxo.2 uc008hxo.3 uc008hxo.4 uc008hxo.5 Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13666; Evidence=; Homooligomer. In vitro interacts with NPR1/GC-A. Cell membrane ; Single-pass type I membrane protein Highly expressed in testis. N-glycosylated. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding peptide receptor activity guanylate cyclase activity protein kinase activity ATP binding GTP binding plasma membrane cGMP biosynthetic process protein phosphorylation signal transduction receptor guanylyl cyclase signaling pathway cyclic nucleotide biosynthetic process external side of plasma membrane membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity intracellular signal transduction uc008hxo.1 uc008hxo.2 uc008hxo.3 uc008hxo.4 uc008hxo.5 
ENSMUST00000069195.5 Zfp46 ENSMUST00000069195.5 zinc finger protein 46, transcript variant 2 (from RefSeq NM_009557.5) ENSMUST00000069195.1 ENSMUST00000069195.2 ENSMUST00000069195.3 ENSMUST00000069195.4 Kiaa1710 Mlz-4 NM_009557 Q03309 Q69ZC6 Q8BPP0 Q8BQC2 ZN436_MOUSE Znf436 uc008vhw.1 uc008vhw.2 uc008vhw.3 May be involved in transcriptional regulation. Nucleus Lens, liver, heart, kidney, spleen and brain. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAA39949.1; Type=Erroneous initiation; Evidence=; Sequence=BAD32518.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated metal ion binding uc008vhw.1 uc008vhw.2 uc008vhw.3 
ENSMUST00000069209.2 Ct55 ENSMUST00000069209.2 cancer/testis antigen 55 (from RefSeq NM_029142.1) CT55_MOUSE ENSMUST00000069209.1 NM_029142 Q14BQ3 Q9D585 uc009tfi.1 uc009tfi.2 uc009tfi.3 Plays a role in spermatogenesis, possibly acting in the regulation of the autophagy pathway. Interacts with GABARAP; this interaction may be important for GABARAP protein stability (By similarity). Interacts with LAMP2; this interaction may be important for LAMP2 protein stability (By similarity). Cytoplasm Cytoplasmic vesicle, secretory vesicle, acrosome Cell projection, cilium, flagellum Note=Mainly observed in the cytoplasm of spermatocyte and spermatogonia, and also found in acrosome or flagellum in early and late spermatids. Expressed in spermatozoa (at protein level). Expressed during spermatogenesis, with highest expression in late spermatids. Detected in the cytoplasm of spermatocyte and spermatogonia. Also found in acrosome or flagellum in early and late spermatids (at protein level). Knockout mice do not exhibit any gross abnormalities and survive to adulthood. Homozygous females are fertile, while the numbers of both litters and pups progressively decrease in hemizygous males over time. Males are totally infertile around 32 weeks of age. molecular_function cellular_component biological_process uc009tfi.1 uc009tfi.2 uc009tfi.3 
ENSMUST00000069245.8 Spink5 ENSMUST00000069245.8 serine peptidase inhibitor, Kazal type 5 (from RefSeq NM_001081180.1) ENSMUST00000069245.1 ENSMUST00000069245.2 ENSMUST00000069245.3 ENSMUST00000069245.4 ENSMUST00000069245.5 ENSMUST00000069245.6 ENSMUST00000069245.7 NM_001081180 Q148R4 Q148R4_MOUSE Spink5 uc008eup.1 uc008eup.2 uc008eup.3 negative regulation of antibacterial peptide production serine-type endopeptidase inhibitor activity extracellular region cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol cell cortex multicellular organism development central nervous system development epidermal cell differentiation cell differentiation regulation of cell adhesion peptidase inhibitor activity intracellular membrane-bounded organelle negative regulation of proteolysis perinuclear region of cytoplasm epidermal lamellar body negative regulation of serine-type endopeptidase activity negative regulation of serine-type peptidase activity uc008eup.1 uc008eup.2 uc008eup.3 
ENSMUST00000069250.14 Zfp57 ENSMUST00000069250.14 zinc finger protein 57, transcript variant 2 (from RefSeq NM_001168501.1) ENSMUST00000069250.1 ENSMUST00000069250.10 ENSMUST00000069250.11 ENSMUST00000069250.12 ENSMUST00000069250.13 ENSMUST00000069250.2 ENSMUST00000069250.3 ENSMUST00000069250.4 ENSMUST00000069250.5 ENSMUST00000069250.6 ENSMUST00000069250.7 ENSMUST00000069250.8 ENSMUST00000069250.9 NM_001168501 Q3UT94 Q62515 Q6JPI1 Q8C6P8 ZFP57_MOUSE uc008clv.1 uc008clv.2 uc008clv.3 uc008clv.4 Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:15070898, PubMed:18854139, PubMed:23059534, PubMed:30602440). Acts together with ZNF445, but ZFP57 plays the predominant role in imprinting maintenance. In contrast, in humans, ZNF445 seems to be the major factor early embryonic imprinting maintenance (PubMed:30602440). Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (PubMed:15070898, PubMed:18854139, PubMed:23059534). Nucleus te=Binds various differentially methylated regions (DMR), including the Snrpn DMR. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C6P8-1; Sequence=Displayed; Name=2; IsoId=Q8C6P8-2; Sequence=VSP_026331; Expressed in oocytes and in a subset of adult tissues. Expressed at high levels in testis, and at low levels in cerebellum. Present in sciatic nerve and spinal cord (at protein level). Expression peaks between 11 dpc and 17 dpc, and decreases from P0 to P28. Expressed in lung throughout embryonic development. At 12 dpc, expressed in spinal cord, dorsal root ganglia and sciatic nerve. At 15 dpc, highly expressed in all neural tissues. At P0, expressed in brain and spinal cord. Present in Schwann cells at 16 dpc and P0 (at protein level). Maternal product is present in preimplantation embryos. Expressed in pluripotent embryonic stem cells. Down-regulated when embryonic stem cells differentiate. Up-regulated by LIF. Down-regulated during differentiation of embryonic stem cells, or during retinoic acid-induced differentiation of F9 cells (at protein level). Regulated by JMJD1A, which mediates histone H3K9Me2 demethylation at its promoter, thereby activating expression. The KRAB domain is required for function as transcriptional repressor. Zinc fingers 2 and 3 mediate recognition of the target element, ZF2 interacting with the 5' half (TGC) and ZF3 interacting with the 3' half (CGC). Affects the maintenance of DNA methylation imprints. The absence of just the zygotic function causes partial neonatal lethality, whereas eliminating both the maternal and zygotic functions results in a highly penetrant embryonic lethality. In oocytes, its absence results in failure to establish maternal methylation imprints at the Snrpn imprinted region. Intriguingly, methylation imprints are reacquired specifically at the maternally derived Snrpn imprinted region when the zygotic Zfp57 is present in embryos (PubMed:18854139, PubMed:30602440). Double zygotic mutations of ZFP57 and ZNF445 are embryonically lethal and embryos show no gross morphological abnormalities but significant reduction in size and weight at 11.5 dpc, a phenotype more pronounced than in ZFP57 mutant mice with a more severe loss of impinting (PubMed:30602440). Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAR04560.1; Type=Miscellaneous discrepancy; Note=Numerous sequencing errors.; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleic acid binding DNA binding protein binding nucleus nuclear heterochromatin regulation of gene expression by genetic imprinting regulation of transcription, DNA-templated multicellular organism development DNA methylation involved in embryo development metal ion binding uc008clv.1 uc008clv.2 uc008clv.3 uc008clv.4 
ENSMUST00000069268.3 Tas2r102 ENSMUST00000069268.3 taste receptor, type 2, member 102 (from RefSeq NM_199153.2) ENSMUST00000069268.1 ENSMUST00000069268.2 F8VPL4 F8VPL4_MOUSE NM_199153 Tas2r102 uc009ejn.1 uc009ejn.2 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor T2R family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane response to stimulus sensory perception of taste uc009ejn.1 uc009ejn.2 
ENSMUST00000069271.5 Dmrtb1 ENSMUST00000069271.5 DMRT-like family B with proline-rich C-terminal, 1, transcript variant 1 (from RefSeq NM_019872.3) A2A9I7 DMRTB_MOUSE Dmrt6 ENSMUST00000069271.1 ENSMUST00000069271.2 ENSMUST00000069271.3 ENSMUST00000069271.4 NM_019872 Q8CGW8 uc008tzy.1 uc008tzy.2 uc008tzy.3 uc008tzy.4 Nucleus Brain. Belongs to the DMRT family. DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated protein homodimerization activity metal ion binding sequence-specific DNA binding uc008tzy.1 uc008tzy.2 uc008tzy.3 uc008tzy.4 
ENSMUST00000069292.14 Zfp248 ENSMUST00000069292.14 zinc finger protein 248, transcript variant 1 (from RefSeq NM_028335.2) ENSMUST00000069292.1 ENSMUST00000069292.10 ENSMUST00000069292.11 ENSMUST00000069292.12 ENSMUST00000069292.13 ENSMUST00000069292.2 ENSMUST00000069292.3 ENSMUST00000069292.4 ENSMUST00000069292.5 ENSMUST00000069292.6 ENSMUST00000069292.7 ENSMUST00000069292.8 ENSMUST00000069292.9 NM_028335 Q640N4 Q640N4_MOUSE Zfp248 uc009dlp.1 uc009dlp.2 uc009dlp.3 molecular_function nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc009dlp.1 uc009dlp.2 uc009dlp.3 
ENSMUST00000069324.7 Zfp580 ENSMUST00000069324.7 zinc finger protein 580 (from RefSeq NM_026900.1) ENSMUST00000069324.1 ENSMUST00000069324.2 ENSMUST00000069324.3 ENSMUST00000069324.4 ENSMUST00000069324.5 ENSMUST00000069324.6 NM_026900 Q9DB38 ZN580_MOUSE Znf580 uc009ezp.1 uc009ezp.2 uc009ezp.3 uc009ezp.4 Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation (By similarity). Interacts with SMAD2. Nucleus Note=Colocalized with SMAD2 in the nucleus. positive regulation of endothelial cell proliferation positive regulation of leukocyte chemotaxis nucleic acid binding DNA binding nucleus chemotaxis inflammatory response positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of interleukin-8 production metal ion binding cellular response to hydrogen peroxide uc009ezp.1 uc009ezp.2 uc009ezp.3 uc009ezp.4 
ENSMUST00000069325.14 Dnai2 ENSMUST00000069325.14 dynein axonemal intermediate chain 2 (from RefSeq NM_001034878.3) A2AC93 A2AC94 DNAI2_MOUSE Dnaic2 ENSMUST00000069325.1 ENSMUST00000069325.10 ENSMUST00000069325.11 ENSMUST00000069325.12 ENSMUST00000069325.13 ENSMUST00000069325.2 ENSMUST00000069325.3 ENSMUST00000069325.4 ENSMUST00000069325.5 ENSMUST00000069325.6 ENSMUST00000069325.7 ENSMUST00000069325.8 ENSMUST00000069325.9 NM_001034878 uc007mfn.1 uc007mfn.2 uc007mfn.3 Part of the dynein complex of respiratory cilia. Consists of at least two heavy chains and a number of intermediate and light chains (Probable). Interacts with DNAAF2 (PubMed:19052621). Interacts with DNAAF6/PIH1D3 (PubMed:24421334). Interacts with HEATR2; probably involved in outer arm dynein assembly (By similarity). A2AC93; Q8BPI1: Dnaaf2; NbExp=2; IntAct=EBI-15744757, EBI-15744709; Cytoplasm, cytoskeleton, cilium axoneme Dynein axonemal particle Note=Located in the proximal region of respiratory cilia. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AC93-1; Sequence=Displayed; Name=2; IsoId=A2AC93-2; Sequence=VSP_036542; Predominantly expressed in ovary, testis and lung. In ovaries, it is detected at high levels in vivo on day 10, with a subsequent decrease on days 15 and 20, in adult and old ovaries. Weakly expressed on day 5. Belongs to the dynein intermediate chain family. Sequence=CAM19252.1; Type=Erroneous gene model prediction; Evidence=; cilium movement motor activity microtubule motor activity protein binding cytoplasm cytoskeleton axonemal dynein complex microtubule cilium axoneme microtubule-based movement determination of left/right symmetry external side of plasma membrane cell projection organization dynein complex sperm flagellum outer dynein arm outer dynein arm assembly cell projection dynein light chain binding dynein heavy chain binding cilium assembly ATP-dependent microtubule motor activity, plus-end-directed uc007mfn.1 uc007mfn.2 uc007mfn.3 
ENSMUST00000069334.8 Dach1 ENSMUST00000069334.8 dachshund family transcription factor 1, transcript variant 3 (from RefSeq NM_001424435.1) B2RUG1 DACH1_MOUSE Dach ENSMUST00000069334.1 ENSMUST00000069334.2 ENSMUST00000069334.3 ENSMUST00000069334.4 ENSMUST00000069334.5 ENSMUST00000069334.6 ENSMUST00000069334.7 NM_001424435 O88716 Q8BPQ0 Q8C8D7 Q9QY47 Q9QYB2 Q9R218 Q9Z0Y5 uc007uus.1 uc007uus.2 uc007uus.3 uc007uus.4 Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1 (By similarity). Binds to chromatin DNA via its DACHbox-N domain. Interacts with SIX1, SIX6 and EYA3. Interacts with NCOR1 and HDAC3 through its N-terminus. Interacts with SIN3A through its C- terminus. Interacts with SMAD3 and SMAD4 (By similarity). Q9QYB2; Q60974: Ncor1; NbExp=2; IntAct=EBI-348961, EBI-349004; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QYB2-1; Sequence=Displayed; Name=2; IsoId=Q9QYB2-2; Sequence=VSP_009489; Expressed at higher levels in adult kidney and lung, and at lower levels in brain and testis. Expressed in embryonal kidneys, eyes, cochleae and limb buds. Highest expression was found at 11.5 dpc, and expression rapidly declines at later stages of the development. Between 8.0 and 13.5 dpc is found in neural crest cells during their pre- migratory, migratory, and, in some cases post-migratory phase throughout the body axis. Also found in lateral mesenchyme of trunk and head. At 10 and 12 dpc found in mesonephric tubules. At 16 dpc found in epithalial cells of metanephric 'comma' and 'S'-shaped bodies, in mesenchymal cells of the medulla and the cortex. Colocalized to the nucleus of glomerular podocytes and epithelial cells lining many of the convoluted tubes. At 10.5 dpc found in both the anterior and posterior of the limb bud. At 11.5 dpc expression becomes increasingly peripheral, extending around the entire handplate in the mesenchymal cells underlying the apical ectodermal ridge. At 12.5 dpc expression is entirely peripheral an by 13.5 dpc is localized to the mesenchyme at the distal tips of the digits. At 10 dpc found in cells of the optic cup and in some cells surrounding the eye. At 12 dpc found in developing lens fibers, the ectoderm overlaying the developing eye and less intensely in the retina. At 12 dpc found in cells of the dorsomedial and dorsolateral epithelium of the otic vesicle. At later stages expressed in only a few specialized cell types of the cochlear duct, including the inner and outer hair cells, stria vascularis, and the mesenchymal cells directly underlying the organ of Corti. From 10.5 to 12.5 dpc expressed in the telencephalon including the olfactory bulbs, throughout the length of the neural tube and within the dorsal root ganglia, in cranial ganglia in the trigeminal ganglion and the glossopharyngeal-vagal ganglion complex. At 10.5 and 11.5 dpc expressed in punctate pattern on the ventral side of the embryo between the fore and hind limbs, the rib primordia; this expression disappears by 12.5 dpc. At 11.5 and 12.5 dpc found in genital eminence. The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain. Belongs to the DACH/dachshund family. Sequence=CAA06665.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding suckling behavior DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm regulation of transcription, DNA-templated multicellular organism development respiratory gaseous exchange cell proliferation negative regulation of transcription by competitive promoter binding negative regulation of cell migration regulation of nuclear cell cycle DNA replication negative regulation of transcription, DNA-templated development of primary female sexual characteristics negative regulation of fibroblast proliferation negative regulation of cell proliferation involved in contact inhibition negative regulation of DNA biosynthetic process uc007uus.1 uc007uus.2 uc007uus.3 uc007uus.4 
ENSMUST00000069360.14 Gpc3 ENSMUST00000069360.14 glypican 3 (from RefSeq NM_016697.3) ENSMUST00000069360.1 ENSMUST00000069360.10 ENSMUST00000069360.11 ENSMUST00000069360.12 ENSMUST00000069360.13 ENSMUST00000069360.2 ENSMUST00000069360.3 ENSMUST00000069360.4 ENSMUST00000069360.5 ENSMUST00000069360.6 ENSMUST00000069360.7 ENSMUST00000069360.8 ENSMUST00000069360.9 GPC3_MOUSE NM_016697 Q8CFZ4 uc009teg.1 uc009teg.2 uc009teg.3 uc009teg.4 uc009teg.5 Cell surface proteoglycan (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI- anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (PubMed:18477453, PubMed:23665349). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (PubMed:18477453). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (By similarity). Positively regulates the non-canonical Wnt signaling pathway (PubMed:15537637). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (PubMed:23665349). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (PubMed:10964473). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (PubMed:11180950). Required for coronary vascular development (PubMed:19733558). Plays a role in regulating cell movements during gastrulation (By similarity). Heterodimer; disulfide-linked (By similarity). Cleavage by a furin-like convertase results in production of alpha and beta chains which form a disulfide-linked heterodimer (By similarity). Interacts with DPP4 (By similarity). Interacts with FGF2 (By similarity). Interacts with WNT5A (By similarity). Also interacts with WNT3A and WNT7B (By similarity). Interacts with hedgehog protein SHH; the heparan sulfate chains are not required for the interaction (PubMed:18477453). Also interacts with hedgehog protein IHH (PubMed:23665349). Interacts with CD81 (PubMed:23665349). Interacts with Wnt receptors FZD4, FZD7 and FZD8; the heparan sulfate chains are required for the interaction (By similarity). Cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side In the developing limb, absent from the apical epidermal ridge at 11 dpc but highly expressed in the underlying mesenchyme (PubMed:10964473). Expression in the mesenchyme at this stage is asymmetric with highest levels in the regions of the distal mesenchyme within the progress zone and within the proximal anterior and posterior limb bud (PubMed:10964473). At later developmental stages including 12.5 and 13.5 dpc, expression is restricted to the interdigital webs and the regions of chondrocytic differentiation of the developing bones (PubMed:10964473). In the embryonic kidney, expressed in both the ureteric bud and mesenchymal cells as early as 13.5 dpc (PubMed:11180950). Expression at 16.5 dpc is similar to that at 13.5 dpc but decreases by 18.5 dpc (PubMed:11180950). O-glycosylated; contains heparan sulfate and/or chondroitin sulfate. Cleaved intracellularly by a furin-like convertase to generate 2 subunits, alpha and beta, which remain associated through disulfide bonds and are associated with the cell surface via the GPI-anchor. This processing is essential for its role in inhibition of hedgehog signaling. A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface. Perinatal death, developmental overgrowth, cystic and dyplastic kidneys, abnormal lung development and ventral wall closure defects (PubMed:10402475, PubMed:10964473). A proportion of mutants also display mandibular hypoplasia and an imperforate vagina (PubMed:10402475). There is an early and persistent abnormality in ureteric bud development in the kidney due to increased cell proliferation (PubMed:10402475). In the developing kidney, cell proliferation is increased threefold in cortical collecting duct cells and apoptosis is increased 16-fold in medullary collecting duct cells (PubMed:11180950). High incidence of congenital cardiac malformations including ventricular septal defects, common atrioventricular canal, double outlet right ventricle and presence of coronary artery fistulas (PubMed:19733558). Elevated levels of hedgehog pathway proteins Gli1 and Ptc1, indicative of activation of the hedgehog pathway and increased levels of Shh (PubMed:18477453). Reduced non-canonical Wnt signaling (PubMed:15537637). Similar levels of tissue and serum Igf2 to wild-type mice (PubMed:10402475). Belongs to the glypican family. branching involved in ureteric bud morphogenesis kidney development protein binding extracellular region lysosome Golgi lumen plasma membrane integral component of plasma membrane negative regulation of cell proliferation response to bacterium animal organ morphogenesis anterior/posterior axis specification regulation of signal transduction cell surface body morphogenesis negative regulation of peptidase activity membrane cell migration bone mineralization osteoclast differentiation lung development peptidase inhibitor activity positive regulation of BMP signaling pathway anchored component of membrane embryonic hindlimb morphogenesis regulation of growth cell migration involved in gastrulation positive regulation of protein catabolic process positive regulation of endocytosis negative regulation of smoothened signaling pathway positive regulation of smoothened signaling pathway negative regulation of growth positive regulation of glucose import anchored component of plasma membrane negative regulation of epithelial cell proliferation peptidyl-dipeptidase inhibitor activity regulation of canonical Wnt signaling pathway coronary vasculature development cell proliferation involved in kidney development mesenchymal cell proliferation involved in ureteric bud development mesonephric duct morphogenesis cell proliferation involved in metanephros development negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of protein localization to membrane regulation of non-canonical Wnt signaling pathway positive regulation of Wnt signaling pathway, planar cell polarity pathway uc009teg.1 uc009teg.2 uc009teg.3 uc009teg.4 uc009teg.5 
ENSMUST00000069399.7 Kbtbd11 ENSMUST00000069399.7 kelch repeat and BTB (POZ) domain containing 11 (from RefSeq NM_029116.2) A3KME3 ENSMUST00000069399.1 ENSMUST00000069399.2 ENSMUST00000069399.3 ENSMUST00000069399.4 ENSMUST00000069399.5 ENSMUST00000069399.6 KBTBB_MOUSE Kiaa0711 NM_029116 Q8BNW9 uc009kzk.1 uc009kzk.2 uc009kzk.3 uc009kzk.4 Sequence=BAC98007.1; Type=Erroneous initiation; Evidence=; uc009kzk.1 uc009kzk.2 uc009kzk.3 uc009kzk.4 
ENSMUST00000069417.6 Gja6 ENSMUST00000069417.6 gap junction protein, alpha 6 (from RefSeq NM_001001496.2) CXA6_MOUSE ENSMUST00000069417.1 ENSMUST00000069417.2 ENSMUST00000069417.3 ENSMUST00000069417.4 ENSMUST00000069417.5 NM_001001496 Q3TFY9 Q6S5G4 Q8BLZ9 uc009utt.1 uc009utt.2 uc009utt.3 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Belongs to the connexin family. Alpha-type (group II) subfamily. plasma membrane gap junction connexin complex cell communication membrane integral component of membrane cell junction uc009utt.1 uc009utt.2 uc009utt.3 
ENSMUST00000069419.8 Ccdc172 ENSMUST00000069419.8 coiled-coil domain containing 172, transcript variant 2 (from RefSeq NM_029372.3) CC172_MOUSE ENSMUST00000069419.1 ENSMUST00000069419.2 ENSMUST00000069419.3 ENSMUST00000069419.4 ENSMUST00000069419.5 ENSMUST00000069419.6 ENSMUST00000069419.7 NM_029372 Q810N9 Q9DAG3 Tekt2bp1 uc008iao.1 uc008iao.2 uc008iao.3 May interact with TEKT2. Cytoplasm Cell projection, cilium Note=In caput spermatozoa, localized in the middle piece, predominantly concentrated at the mitochondrial sheath of the flagella and to a lesser extent with outer dense fibers (ODF) (By similarity). Colocalized with TEKT2 at the perinuclear region (PubMed:24394471). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q810N9-1; Sequence=Displayed; Name=2; IsoId=Q810N9-2; Sequence=VSP_034843; Belongs to the CCDC172 family. molecular_function cytoplasm cilium biological_process cell projection sperm midpiece uc008iao.1 uc008iao.2 uc008iao.3 
ENSMUST00000069431.5 Gm9978 ENSMUST00000069431.5 Gm9978 (from geneSymbol) AK081416 ENSMUST00000069431.1 ENSMUST00000069431.2 ENSMUST00000069431.3 ENSMUST00000069431.4 uc287spr.1 uc287spr.2 uc287spr.1 uc287spr.2 
ENSMUST00000069443.14 Slain1 ENSMUST00000069443.14 SLAIN motif family, member 1, transcript variant 2 (from RefSeq NM_198014.3) ENSMUST00000069443.1 ENSMUST00000069443.10 ENSMUST00000069443.11 ENSMUST00000069443.12 ENSMUST00000069443.13 ENSMUST00000069443.2 ENSMUST00000069443.3 ENSMUST00000069443.4 ENSMUST00000069443.5 ENSMUST00000069443.6 ENSMUST00000069443.7 ENSMUST00000069443.8 ENSMUST00000069443.9 NM_198014 Q68FF7 Q8R3I6 SLAI1_MOUSE uc007uws.1 uc007uws.2 uc007uws.3 uc007uws.4 Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation. Interacts with MAPRE1, MAPRE2, MAPRE3 and CKAP5 (PubMed:21646404). Interacts with ZDHHC17 (via ANK repeats) (By similarity). Cytoplasm, cytoskeleton Note=Colocalizes with microtubules. Detected at the plus end of growing microtubules. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q68FF7-1; Sequence=Displayed; Name=2; IsoId=Q68FF7-2; Sequence=VSP_030833; Expressed in embryonic stem cells (PubMed:16546155). Expressed in adult bone marrow, brain, kidney, lung, testis and thymus (PubMed:16546155, PubMed:20563991). Expressed in colon (PubMed:20563991). Isoform 1 is highly expressed in brain (PubMed:20563991). Isoform 2 is more widely expressed in bone marrow, brain, colon, kidney, lung and thymus (PubMed:20563991). During embryonic stem cell differentiation, expression peaks at d2 and d3 (epiblast stage) (PubMed:16546155). In postimplantation embryos widely expressed throughout 6.5-7.0 dpc, followed by higher levels of expression in the headfold neurectoderm at 7.5 dpc (PubMed:16546155). At 8.5 dpc, observed in the neural tube and optic vesicles (PubMed:16546155). At 9.0-9.5 dpc, expressed at sites of imminent neural tube closure in the midbrain, hindbrain, and tailbud and in the dorsal aspects of the somites (PubMed:16546155). At 9.5 dpc, expressed within the neuroepithelium surrounding the telencephalic, mesencephalic and optic vesicles and in neural crest cells on either side of the mesencephalic vesicles, along the neural tube continuous with the tailbud, in the neural crest-derived dorsal root ganglia, in the surface ectoderm of the branchial arches as well as the primitive gut tube (PubMed:20563991). At 11.5 dpc, predominantly expressed within the forebrain, eye and neural tube, and weaker expression within the optic and oropharyngeal regions, in the epithelium of the olfactory pit, optic stalk and otic vesicle, parts of the gut tube, particularly within the lumen of the midgut loop and the stomach, in branchial arches and in the condensing mesenchyme of the developing limb buds (PubMed:20563991). At 11.5 dpc, also expressed within the neuroepithelium surrounding both the fourth and telencephalic ventricles (PubMed:20563991). At 13.5 dpc, expressed throughout the developing nervous system with most prominent expression in forebrain, midbrain and spinal cord, including the dorsal root ganglia and the olfactory bulb and within the endoderm derived midgut loop in the physiological umbilical hernia, as well as in the eye and in the main bronchi of the lung and within the developing metanephric tubules (PubMed:20563991). At 13.5 dpc, also expressed at the superficial layers of the neuroepithelium and the ependymal layers surrounding the fourth and lateral ventricles and in neurons of the dorsal root ganglia and in dorsal roots between the cartilage primordia as well as in cranial sensory ganglia (PubMed:20563991). Also expressed along the apical epidermal ridge and in the forelimb and hind limb (PubMed:20563991). Belongs to the SLAIN motif-containing family. molecular_function cellular_component cytoplasm cytoskeleton biological_process uc007uws.1 uc007uws.2 uc007uws.3 uc007uws.4 
ENSMUST00000069449.7 Rras2 ENSMUST00000069449.7 related RAS viral (r-ras) oncogene 2 (from RefSeq NM_025846.2) ENSMUST00000069449.1 ENSMUST00000069449.2 ENSMUST00000069449.3 ENSMUST00000069449.4 ENSMUST00000069449.5 ENSMUST00000069449.6 NM_025846 P17082 P62071 Q3TA79 Q8C5D1 Q9D0H6 RRAS2_MOUSE Rras2 uc009jhw.1 uc009jhw.2 uc009jhw.3 GTP-binding protein with GTPase activity involved in the regulation of MAPK signaling pathway, thereby controlling multiple cellular processes. Involved in the regulation of MAPK signaling pathway. Regulation of craniofacial development. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Interacts with RASSF5. Cell membrane ; Lipid-anchor ; Cytoplasmic side Golgi apparatus membrane ; Lipid-anchor May be post-translationally modified by both palmitoylation and polyisoprenylation. Fatty-acylation at Lys-192, Lys-194; lys-196 and Lys-197 is required for localization to the plasma membrane and activity. Defatty- acylated by SIRT6, affecting its localization to the plasma membrane. Belongs to the small GTPase superfamily. Ras family. nucleotide binding GTPase activity protein binding GTP binding plasma membrane signal transduction Ras protein signal transduction cellular process membrane GDP binding positive regulation of cell migration regulation of neuron death uc009jhw.1 uc009jhw.2 uc009jhw.3 
ENSMUST00000069451.11 Ghr ENSMUST00000069451.11 growth hormone receptor, transcript variant 1 (from RefSeq NM_010284.3) ENSMUST00000069451.1 ENSMUST00000069451.10 ENSMUST00000069451.2 ENSMUST00000069451.3 ENSMUST00000069451.4 ENSMUST00000069451.5 ENSMUST00000069451.6 ENSMUST00000069451.7 ENSMUST00000069451.8 ENSMUST00000069451.9 Ghr NM_010284 Q3UP14 Q3UP14_MOUSE uc007vcc.1 uc007vcc.2 uc007vcc.3 uc007vcc.4 The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Cell membrane ; Single-pass type I membrane protein Belongs to the type I cytokine receptor family. Type 1 subfamily. activation of MAPK activity cytokine receptor activity growth hormone receptor activity extracellular space nucleus cytoplasm mitochondrion cytosol plasma membrane JAK-STAT cascade response to hormone hormone-mediated signaling pathway membrane integral component of membrane cytokine-mediated signaling pathway protein kinase binding protein phosphatase binding response to food cellular response to insulin stimulus response to cytokine cytoplasmic ribonucleoprotein granule SH2 domain binding activation of Janus kinase activity neuronal cell body response to morphine response to peptide hormone positive regulation of cell differentiation positive regulation of JAK-STAT cascade response to glucocorticoid cartilage development involved in endochondral bone morphogenesis growth hormone receptor signaling pathway response to growth hormone response to interleukin-1 negative regulation of neuron death uc007vcc.1 uc007vcc.2 uc007vcc.3 uc007vcc.4 
ENSMUST00000069453.9 Paqr3 ENSMUST00000069453.9 progestin and adipoQ receptor family member III, transcript variant 2 (from RefSeq NM_198422.3) ENSMUST00000069453.1 ENSMUST00000069453.2 ENSMUST00000069453.3 ENSMUST00000069453.4 ENSMUST00000069453.5 ENSMUST00000069453.6 ENSMUST00000069453.7 ENSMUST00000069453.8 NM_198422 PAQR3_MOUSE Paqr3 Q6TCG8 uc008yfq.1 uc008yfq.2 Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi. Golgi apparatus membrane ; Multi-pass membrane protein Belongs to the ADIPOR family. Golgi membrane negative regulation of protein phosphorylation Golgi apparatus negative regulation of neuron projection development membrane integral component of membrane negative regulation of peptidyl-serine phosphorylation protein localization to Golgi apparatus signaling receptor activity negative regulation of MAP kinase activity uc008yfq.1 uc008yfq.2 
ENSMUST00000069457.3 Gm9979 ENSMUST00000069457.3 predicted gene 9979 (from RefSeq NR_188820.1) ENSMUST00000069457.1 ENSMUST00000069457.2 NR_188820 uc288mgi.1 uc288mgi.2 uc288mgi.3 uc288mgi.1 uc288mgi.2 uc288mgi.3 
ENSMUST00000069476.5 Rtl6 ENSMUST00000069476.5 retrotransposon Gag like 6 (from RefSeq NM_177630.4) ENSMUST00000069476.1 ENSMUST00000069476.2 ENSMUST00000069476.3 ENSMUST00000069476.4 Ldoc1l Mar6 Mart6 NM_177630 Q505G4 Q8BNE4 RTL6_MOUSE Rtl6 Sushi-15E3 uc007xcc.1 uc007xcc.2 Widely expressed. Expressed at 14.5 dpc. RTL6 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. Belongs to the LDOC1 family. Sequence=BAC39047.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc007xcc.1 uc007xcc.2 
ENSMUST00000069483.12 Fbrsl1 ENSMUST00000069483.12 fibrosin-like 1, transcript variant 1 (from RefSeq NM_001142642.1) E9Q9T0 E9Q9T0_MOUSE ENSMUST00000069483.1 ENSMUST00000069483.10 ENSMUST00000069483.11 ENSMUST00000069483.2 ENSMUST00000069483.3 ENSMUST00000069483.4 ENSMUST00000069483.5 ENSMUST00000069483.6 ENSMUST00000069483.7 ENSMUST00000069483.8 ENSMUST00000069483.9 Fbrsl1 NM_001142642 uc012ebb.1 uc012ebb.2 uc012ebb.3 uc012ebb.4 cellular_component biological_process uc012ebb.1 uc012ebb.2 uc012ebb.3 uc012ebb.4 
ENSMUST00000069486.13 Gemin6 ENSMUST00000069486.13 gem nuclear organelle associated protein 6, transcript variant 1 (from RefSeq NM_026053.4) ENSMUST00000069486.1 ENSMUST00000069486.10 ENSMUST00000069486.11 ENSMUST00000069486.12 ENSMUST00000069486.2 ENSMUST00000069486.3 ENSMUST00000069486.4 ENSMUST00000069486.5 ENSMUST00000069486.6 ENSMUST00000069486.7 ENSMUST00000069486.8 ENSMUST00000069486.9 GEMI6_MOUSE NM_026053 Q3TIW7 Q9CQI0 Q9CX53 Q9CXC5 uc008dqv.1 uc008dqv.2 uc008dqv.3 The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre- mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts with GEMIN7; the interaction is direct. Interacts with GEMIN8; the interaction is direct. Interacts with SNRPB, SNRPD2, SNRPD3 and SNRPE; the interaction is direct. Nucleus, nucleoplasm Nucleus, gem Cytoplasm Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm (By similarity). spliceosomal complex assembly spliceosomal snRNP assembly protein binding nucleus nucleoplasm cytoplasm cytosol mRNA processing RNA splicing nuclear body SMN complex SMN-Sm protein complex Gemini of coiled bodies uc008dqv.1 uc008dqv.2 uc008dqv.3 
ENSMUST00000069503.13 Tubd1 ENSMUST00000069503.13 tubulin, delta 1, transcript variant 2 (from RefSeq NM_019756.3) ENSMUST00000069503.1 ENSMUST00000069503.10 ENSMUST00000069503.11 ENSMUST00000069503.12 ENSMUST00000069503.2 ENSMUST00000069503.3 ENSMUST00000069503.4 ENSMUST00000069503.5 ENSMUST00000069503.6 ENSMUST00000069503.7 ENSMUST00000069503.8 ENSMUST00000069503.9 NM_019756 Q9R1K7 TBD_MOUSE uc007ksu.1 uc007ksu.2 uc007ksu.3 Acts as a positive regulator of hedgehog signaling and regulates ciliary function (PubMed:29290584). Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1. Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm Nucleus Note=Associated with centrioles (PubMed:10753753). Both cytoplasmic and nuclear (PubMed:10753753). In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head (PubMed:10753753). Highly expressed in testis. Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle GTPase activity structural constituent of cytoskeleton GTP binding nucleus nucleoplasm cytoplasm centriole cytosol cytoskeleton microtubule cilium microtubule-based process multicellular organism development cell projection organization cell projection positive regulation of smoothened signaling pathway uc007ksu.1 uc007ksu.2 uc007ksu.3 
ENSMUST00000069507.9 C4b ENSMUST00000069507.9 complement C4B (Chido blood group) (from RefSeq NM_009780.2) C4 CO4B_MOUSE E9QKK7 ENSMUST00000069507.1 ENSMUST00000069507.2 ENSMUST00000069507.3 ENSMUST00000069507.4 ENSMUST00000069507.5 ENSMUST00000069507.6 ENSMUST00000069507.7 ENSMUST00000069507.8 NM_009780 O70346 P01029 Q31201 Q3TYY1 Q3TZC9 Q61372 Q61859 Q62353 Q6NWV8 uc008cdk.1 uc008cdk.2 uc008cdk.3 uc008cdk.4 uc008cdk.5 Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. Catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens (By similarity). Circulates in blood as a disulfide-linked trimer of an alpha, beta and gamma chain. Secreted Synapse Cell projection, axon Cell projection, dendrite Prior to secretion, the single-chain precursor is enzymatically cleaved to yield non-identical chains alpha, beta and gamma. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase. C4 is a major histocompatibility complex class-III protein. complement binding complement component C1q binding immune system process endopeptidase inhibitor activity extracellular region extracellular space inflammatory response complement activation complement activation, classical pathway negative regulation of endopeptidase activity immunoglobulin mediated immune response cell junction carbohydrate binding axon dendrite cell projection neuronal cell body other organism cell innate immune response synapse uc008cdk.1 uc008cdk.2 uc008cdk.3 uc008cdk.4 uc008cdk.5 
ENSMUST00000069511.8 Abcd2 ENSMUST00000069511.8 ATP-binding cassette, sub-family D member 2, transcript variant 4 (from RefSeq NR_177950.1) A0A0R4J0U5 ABCD2_MOUSE Aldr ENSMUST00000069511.1 ENSMUST00000069511.2 ENSMUST00000069511.3 ENSMUST00000069511.4 ENSMUST00000069511.5 ENSMUST00000069511.6 ENSMUST00000069511.7 NR_177950 Q61285 Q8BQ63 Q8C4B6 uc007xhx.1 uc007xhx.2 uc007xhx.3 ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)- CoA from the cytosol to the peroxisome lumen (By similarity). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (By similarity). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) (By similarity). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:18854420, PubMed:16223892). Reaction=a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+); Xref=Rhea:RHEA:67072, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950, ChEBI:CHEBI:138261; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67073; Evidence=; Reaction=a very long-chain fatty acid(in) + ATP + H2O = a very long- chain fatty acid(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:67080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58950, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67081; Evidence=; Homodimers. Homotetramers. The minimal functional unit is a homodimer but the major oligomeric form in peroxisomal membrane is a homotetramer. Forms heterotramers with ABCD1. Forms heterodimers with ABCD3. In addition to tetramers, some larger molecular assemblies are also found but represented only a minor fraction. Interacts with PEX19. Peroxisome membrane ; Multi-pass membrane protein Strongly expressed in brain and adrenals, and weakly expressed in liver. Deficient mice exhibit a late-onset cerebellar and sensory ataxia, loss of Purkinje cells, dorsal root ganglia cell degeneration, axonal degeneration in the spinal cord, and an accumulation of very long chain fatty acids (C26:0 and C24:0) in dorsal root ganglia cells, and reduced levels of C22:6omega3 in primary neurons. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. very long-chain fatty acid metabolic process nucleotide binding protein binding ATP binding mitochondrion peroxisome peroxisomal membrane fatty acid beta-oxidation response to bacterium membrane integral component of membrane ATPase activity positive regulation of fatty acid beta-oxidation ATPase activity, coupled to transmembrane movement of substances very long-chain fatty acid catabolic process protein homodimerization activity myelin maintenance transmembrane transport negative regulation of cytokine production involved in inflammatory response negative regulation of reactive oxygen species biosynthetic process neuron projection maintenance positive regulation of unsaturated fatty acid biosynthetic process uc007xhx.1 uc007xhx.2 uc007xhx.3 
ENSMUST00000069520.11 Syp ENSMUST00000069520.11 synaptophysin (from RefSeq NM_009305.2) ENSMUST00000069520.1 ENSMUST00000069520.10 ENSMUST00000069520.2 ENSMUST00000069520.3 ENSMUST00000069520.4 ENSMUST00000069520.5 ENSMUST00000069520.6 ENSMUST00000069520.7 ENSMUST00000069520.8 ENSMUST00000069520.9 NM_009305 Q62277 Q8BRQ0 Q91WI8 SYPH_MOUSE uc009sls.1 uc009sls.2 uc009sls.3 uc009sls.4 Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity. Homohexamer or homotetramer. Interacts with SRCIN1 (By similarity). Interacts with VAMP2; the interaction is inhibit by interaction of VAPM2 with SEPT8 (PubMed:19196426). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Synapse, synaptosome The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein. Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. Phosphorylated by SRC. Mice lackin both SYNGR1 and SYP show normal brain structure and composition, but impaired short-term and long-term synaptic plasticity. Belongs to the synaptophysin/synaptobrevin family. SNARE binding protein binding endocytosis chemical synaptic transmission synaptic vesicle postsynaptic density cholesterol binding membrane integral component of membrane syntaxin-1 binding protein domain specific binding cell junction integral component of synaptic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle neuromuscular junction macromolecular complex SH2 domain binding presynaptic membrane identical protein binding neuron projection terminal bouton intracellular organelle neuron projection terminus neuron spine macromolecular complex binding synapse regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity regulation of short-term neuronal synaptic plasticity perinuclear region of cytoplasm synaptic vesicle endocytosis presynaptic active zone excitatory synapse cellular response to organic substance regulation of synaptic vesicle exocytosis regulation of opioid receptor signaling pathway uc009sls.1 uc009sls.2 uc009sls.3 uc009sls.4 
ENSMUST00000069536.12 Tcf7l1 ENSMUST00000069536.12 transcription factor 7 like 1 (T cell specific, HMG box), transcript variant 2 (from RefSeq NM_009332.3) A1A550 A1A550_MOUSE ENSMUST00000069536.1 ENSMUST00000069536.10 ENSMUST00000069536.11 ENSMUST00000069536.2 ENSMUST00000069536.3 ENSMUST00000069536.4 ENSMUST00000069536.5 ENSMUST00000069536.6 ENSMUST00000069536.7 ENSMUST00000069536.8 ENSMUST00000069536.9 NM_009332 Tcf3 Tcf7l1 uc009cja.1 uc009cja.2 uc009cja.3 uc009cja.4 Nucleus Belongs to the TCF/LEF family. DNA binding nucleus regulation of transcription from RNA polymerase II promoter beta-catenin binding Wnt signaling pathway canonical Wnt signaling pathway uc009cja.1 uc009cja.2 uc009cja.3 uc009cja.4 
ENSMUST00000069538.14 Elapor2 ENSMUST00000069538.14 endosome-lysosome associated apoptosis and autophagy regulator family member 2, transcript variant 7 (from RefSeq NR_153371.1) ELAP2_MOUSE ENSMUST00000069538.1 ENSMUST00000069538.10 ENSMUST00000069538.11 ENSMUST00000069538.12 ENSMUST00000069538.13 ENSMUST00000069538.2 ENSMUST00000069538.3 ENSMUST00000069538.4 ENSMUST00000069538.5 ENSMUST00000069538.6 ENSMUST00000069538.7 ENSMUST00000069538.8 ENSMUST00000069538.9 Eig121l Elapor2 NR_153371 Q3UZV7 Q8BJM9 Q8BJN9 Q8BJT7 Q8BKX9 Q8BL89 Q8BLT1 Q8BM91 uc008wlk.1 uc008wlk.2 uc008wlk.3 Functions as a regulator of the BMP signaling pathway and may be involved in epidermal differentiation. Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q3UZV7-1; Sequence=Displayed; Name=2; IsoId=Q3UZV7-2; Sequence=VSP_033539; Name=3; IsoId=Q3UZV7-3; Sequence=VSP_033531, VSP_033539; Name=4; IsoId=Q3UZV7-4; Sequence=VSP_033532, VSP_033535; Name=5; IsoId=Q3UZV7-5; Sequence=VSP_033531, VSP_033537, VSP_033538; Name=6; IsoId=Q3UZV7-6; Sequence=VSP_033533; Name=7; IsoId=Q3UZV7-7; Sequence=VSP_033534, VSP_033536; Belongs to the ELAPOR family. Sequence=BAC33441.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; Sequence=BAC33441.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008wlk.1 uc008wlk.2 uc008wlk.3 
ENSMUST00000069549.3 Cldn17 ENSMUST00000069549.3 claudin 17 (from RefSeq NM_181490.3) CLD17_MOUSE ENSMUST00000069549.1 ENSMUST00000069549.2 NM_181490 Q8BXA6 uc007zuy.1 uc007zuy.2 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with the Cldn8 gene on chromosome 16. [provided by RefSeq, Aug 2010]. ##Evidence-Data-START## Transcript is intronless :: AK048287.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability. Interacts with OCLN. Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Expressed at high levels in the kidney and at mucher lower levels in the brain. In the kidney, expression gradually decreases from the proximal tubule downstream to the distal convoluted tubule. Expressed in the thin ascending limb of Henle's loop, as well as in the thick ascending limb of Henle's loop. In the distal convoluted tubules, expressed only in a few tubules. Not detected in the collecting duct. In the brain, expressed in blood vessels (at protein level). Belongs to the claudin family. molecular_function structural molecule activity chloride channel activity plasma membrane bicellular tight junction ion transport chloride transport biological_process membrane integral component of membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction chloride channel complex identical protein binding chloride transmembrane transport uc007zuy.1 uc007zuy.2 
ENSMUST00000069556.4 Magea5 ENSMUST00000069556.4 Magea5 (from geneSymbol) BC109340 ENSMUST00000069556.1 ENSMUST00000069556.2 ENSMUST00000069556.3 Magea5 O89009 O89009_MOUSE uc033jvc.1 uc033jvc.2 uc033jvc.3 molecular_function cellular_component biological_process uc033jvc.1 uc033jvc.2 uc033jvc.3 
ENSMUST00000069557.14 Smad5 ENSMUST00000069557.14 SMAD family member 5, transcript variant 1 (from RefSeq NM_008541.3) ENSMUST00000069557.1 ENSMUST00000069557.10 ENSMUST00000069557.11 ENSMUST00000069557.12 ENSMUST00000069557.13 ENSMUST00000069557.2 ENSMUST00000069557.3 ENSMUST00000069557.4 ENSMUST00000069557.5 ENSMUST00000069557.6 ENSMUST00000069557.7 ENSMUST00000069557.8 ENSMUST00000069557.9 Madh5 Msmad5 NM_008541 P70341 P97454 Q810K0 SMAD5_MOUSE uc007qsz.1 uc007qsz.2 uc007qsz.3 uc007qsz.4 Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:10079220, PubMed:12393578). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:26304548). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes. Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis. Homodimer. Forms trimers with the co-SMAD SMAD4 (By similarity). Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2. Interacts (via MH2 domain) with LEMD3. Interacts with WWP1. Interacts with TMEM119 (PubMed:21239498). Interacts with ZNF8 (PubMed:12370310). Interacts with RANBP3L (By similarity). Interacts with HK1 (By similarity). Interacts with HGS; this interaction attenuates BMP signaling (By similarity). P97454; Q62424: Hoxa13; NbExp=3; IntAct=EBI-7066475, EBI-925160; Cytoplasm Nucleus Mitochondrion Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Predominantly expressed in mesenchyme and somites during embryogenesis, and present in many tissues of the adult. Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase. Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1. Disruption of SMAD5 gene leads to the mid- gestation death of mutant embryos largely due to extraembryonic yolk sac defects. Belongs to the dwarfin/SMAD family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding ossification angiogenesis ureteric bud development Mullerian duct regression osteoblast fate commitment DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated protein phosphorylation transforming growth factor beta receptor signaling pathway multicellular organism development germ cell development embryonic pattern specification DEAD/H-box RNA helicase binding cell differentiation erythrocyte differentiation BMP signaling pathway ubiquitin protein ligase binding macromolecular complex positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding cartilage development cardiac muscle contraction bone development SMAD protein signal transduction cellular response to organic cyclic compound cellular response to BMP stimulus positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus uc007qsz.1 uc007qsz.2 uc007qsz.3 uc007qsz.4 
ENSMUST00000069562.6 Tescl ENSMUST00000069562.6 tescalcin-like (from RefSeq NM_001163810.1) 1700008P20Rik ENSMUST00000069562.1 ENSMUST00000069562.2 ENSMUST00000069562.3 ENSMUST00000069562.4 ENSMUST00000069562.5 NM_001163810 Q9DAJ7 Q9DAJ7_MOUSE Tescl uc009fpi.1 uc009fpi.2 uc009fpi.3 uc009fpi.4 molecular_function calcium ion binding cellular_component biological_process uc009fpi.1 uc009fpi.2 uc009fpi.3 uc009fpi.4 
ENSMUST00000069579.7 Elob ENSMUST00000069579.7 elongin B (from RefSeq NM_026305.2) ELOB_MOUSE ENSMUST00000069579.1 ENSMUST00000069579.2 ENSMUST00000069579.3 ENSMUST00000069579.4 ENSMUST00000069579.5 ENSMUST00000069579.6 Elob NM_026305 P62869 Q63529 Q80W20 Tceb2 uc008atr.1 uc008atr.2 uc008atr.3 SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (PubMed:27863225, PubMed:27863226). Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. This includes the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. As part of a multisubunit ubiquitin ligase complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (By similarity). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (PubMed:33590678). Protein modification; protein ubiquitination. Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit (PubMed:16498413). The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED- EZH2 complex (PubMed:27863225, PubMed:27863226). Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either ASB2, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, SOCS1, SOCS5, ELOA, VHL or WSB1. Interacts with VHL. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2. Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component. May also interact with DCUN1D1, DCUN1D2, DCUN1D3 and DCUN1D5 (By similarity). As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1 (By similarity). Component of the ECS(PCMTD1) complex with the substrate recognition subunit PCMTD1. Interacts with PCMTD1 (via the BC-box); the interaction is direct and stabilizes PCMTD1 (By similarity). Nucleus transcription coactivator activity protein binding nucleus transcription factor complex transcription elongation from RNA polymerase II promoter protein ubiquitination VCB complex Cul2-RING ubiquitin ligase complex Cul5-RING ubiquitin ligase complex ubiquitin protein ligase binding macromolecular complex binding positive regulation of transcription from RNA polymerase II promoter elongin complex uc008atr.1 uc008atr.2 uc008atr.3 
ENSMUST00000069600.13 Ndrg3 ENSMUST00000069600.13 N-myc downstream regulated gene 3, transcript variant 1 (from RefSeq NM_180956.1) ENSMUST00000069600.1 ENSMUST00000069600.10 ENSMUST00000069600.11 ENSMUST00000069600.12 ENSMUST00000069600.2 ENSMUST00000069600.3 ENSMUST00000069600.4 ENSMUST00000069600.5 ENSMUST00000069600.6 ENSMUST00000069600.7 ENSMUST00000069600.8 ENSMUST00000069600.9 NM_180956 Ndrg3 Q8VCV2 Q8VCV2_MOUSE uc008nog.1 uc008nog.2 uc008nog.3 uc008nog.4 Belongs to the NDRG family. cytoplasm uc008nog.1 uc008nog.2 uc008nog.3 uc008nog.4 
ENSMUST00000069604.15 Mthfr ENSMUST00000069604.15 methylenetetrahydrofolate reductase, transcript variant 3 (from RefSeq NR_027809.1) A2A7F7 A2A7F7_MOUSE ENSMUST00000069604.1 ENSMUST00000069604.10 ENSMUST00000069604.11 ENSMUST00000069604.12 ENSMUST00000069604.13 ENSMUST00000069604.14 ENSMUST00000069604.2 ENSMUST00000069604.3 ENSMUST00000069604.4 ENSMUST00000069604.5 ENSMUST00000069604.6 ENSMUST00000069604.7 ENSMUST00000069604.8 ENSMUST00000069604.9 Mthfr NR_027809 uc008vtx.1 uc008vtx.2 uc008vtx.3 uc008vtx.4 Reaction=(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10- methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH; Xref=Rhea:RHEA:19817, ChEBI:CHEBI:15378, ChEBI:CHEBI:15636, ChEBI:CHEBI:18608, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.53; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:19819; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= One-carbon metabolism; tetrahydrofolate interconversion. Belongs to the methylenetetrahydrofolate reductase family. response to hypoxia neural tube closure methylenetetrahydrofolate reductase (NAD(P)H) activity cytosol methionine metabolic process oxidoreductase activity regulation of histone methylation response to vitamin B2 tetrahydrofolate interconversion response to drug response to amino acid macromolecular complex binding synapse S-adenosylmethionine metabolic process tetrahydrofolate metabolic process flavin adenine dinucleotide binding NADP binding homocysteine metabolic process response to folic acid oxidation-reduction process response to interleukin-1 heterochromatin maintenance modified amino acid binding uc008vtx.1 uc008vtx.2 uc008vtx.3 uc008vtx.4 
ENSMUST00000069609.12 Pou2f1 ENSMUST00000069609.12 POU domain, class 2, transcription factor 1, transcript variant 3 (from RefSeq NM_198933.3) ENSMUST00000069609.1 ENSMUST00000069609.10 ENSMUST00000069609.11 ENSMUST00000069609.2 ENSMUST00000069609.3 ENSMUST00000069609.4 ENSMUST00000069609.5 ENSMUST00000069609.6 ENSMUST00000069609.7 ENSMUST00000069609.8 ENSMUST00000069609.9 NM_198933 Oct-1 Otf-1 Otf1 P25425 PO2F1_MOUSE Q61994 Q63891 Q6Y681 Q7TSD0 Q8BT04 Q8K570 Q99JH0 Q9WTZ4 Q9WTZ5 Q9WTZ6 uc007djx.1 uc007djx.2 uc007djx.3 uc007djx.4 Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. Interacts with POU2AF1; the interaction increases POU2F1 transactivation activity. Interacts with NR3C1, AR, PGR and HCFC1. Nucleus. Event=Alternative splicing; Named isoforms=12; Name=1; Synonyms=OCT-1A; IsoId=P25425-1; Sequence=Displayed; Name=2; Synonyms=OCT-1B; IsoId=P25425-2; Sequence=VSP_002321; Name=3; Synonyms=OCT-1C; IsoId=P25425-3; Sequence=VSP_002321, VSP_002322, VSP_002323; Name=4; Synonyms=OCT-1R; IsoId=P25425-4; Sequence=VSP_007271, VSP_007272, VSP_002321, VSP_007273; Name=5; Synonyms=OCT-1L; IsoId=P25425-5; Sequence=VSP_007271, VSP_002321; Name=6; IsoId=P25425-6; Sequence=VSP_007278; Name=7; IsoId=P25425-7; Sequence=VSP_007276, VSP_007277; Name=8; IsoId=P25425-8; Sequence=VSP_007278, VSP_002322, VSP_002323; Name=9; IsoId=P25425-9; Sequence=VSP_007274, VSP_007275; Name=10; Synonyms=OCT-1Z; IsoId=P25425-10; Sequence=VSP_013404, VSP_013405; Name=11; IsoId=P25425-11; Sequence=VSP_007271, VSP_007273; Name=12; IsoId=P25425-12; Sequence=VSP_013403; Ubiquitously expressed. However, isoforms 4 and 5 are only expressed in lymphocytes. Phosphorylated by PRKDC. Belongs to the POU transcription factor family. Class-2 subfamily. transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding receptor binding protein binding nucleus nucleoplasm transcription factor complex endoplasmic reticulum regulation of transcription, DNA-templated negative regulation of gene expression olfactory placode formation intracellular membrane-bounded organelle sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lens induction in camera-type eye RNA polymerase II transcription factor complex uc007djx.1 uc007djx.2 uc007djx.3 uc007djx.4 
ENSMUST00000069614.7 Dcdc2a ENSMUST00000069614.7 doublecortin domain containing 2a, transcript variant 1 (from RefSeq NM_177577.3) Dcdc2a ENSMUST00000069614.1 ENSMUST00000069614.2 ENSMUST00000069614.3 ENSMUST00000069614.4 ENSMUST00000069614.5 ENSMUST00000069614.6 NM_177577 R4GML1 R4GML1_MOUSE uc007pww.1 uc007pww.2 uc007pww.3 uc007pww.4 This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Sep 2010]. neuron migration nucleoplasm cytoplasm microtubule organizing center cytosol cytoskeleton cilium axoneme sensory perception of sound microtubule cytoskeleton kinesin binding regulation of Wnt signaling pathway intracellular signal transduction positive regulation of smoothened signaling pathway kinocilium cilium assembly mitotic spindle regulation of cilium assembly uc007pww.1 uc007pww.2 uc007pww.3 uc007pww.4 
ENSMUST00000069620.10 Per2 ENSMUST00000069620.10 period circadian clock 2, transcript variant 3 (from RefSeq NR_185210.1) A0A0R4J0U3 A0A0R4J0U3_MOUSE ENSMUST00000069620.1 ENSMUST00000069620.2 ENSMUST00000069620.3 ENSMUST00000069620.4 ENSMUST00000069620.5 ENSMUST00000069620.6 ENSMUST00000069620.7 ENSMUST00000069620.8 ENSMUST00000069620.9 NR_185210 Per2 uc007cav.1 uc007cav.2 uc007cav.3 Cytoplasm Nucleus negative regulation of transcription from RNA polymerase II promoter nucleus circadian rhythm negative regulation of transcription, DNA-templated uc007cav.1 uc007cav.2 uc007cav.3 
ENSMUST00000069623.12 Arhgef10l ENSMUST00000069623.12 Rho guanine nucleotide exchange factor 10-like, transcript variant 2 (from RefSeq NM_001112722.1) A2AWP5 A2AWP8 A2AWP9 A2AWQ0 A2AWQ1 ARGAL_MOUSE ENSMUST00000069623.1 ENSMUST00000069623.10 ENSMUST00000069623.11 ENSMUST00000069623.2 ENSMUST00000069623.3 ENSMUST00000069623.4 ENSMUST00000069623.5 ENSMUST00000069623.6 ENSMUST00000069623.7 ENSMUST00000069623.8 ENSMUST00000069623.9 Kiaa1626 NM_001112722 Q6PCQ2 Q6ZPL3 Q8C1A1 Q8VDH5 uc008vmy.1 uc008vmy.2 uc008vmy.3 uc008vmy.4 Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. Interacts with RHOA, RHOB and RHOC. Cytoplasm Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A2AWP8-1; Sequence=Displayed; Name=2; IsoId=A2AWP8-2; Sequence=VSP_034428; Name=3; IsoId=A2AWP8-3; Sequence=VSP_034428, VSP_034431; Name=4; IsoId=A2AWP8-4; Sequence=VSP_034431; Name=5; IsoId=A2AWP8-5; Sequence=VSP_034427, VSP_034429, VSP_034430, VSP_034431; Sequence=BAC98218.1; Type=Erroneous initiation; Evidence=; guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity cytoplasm cytosol actin cytoskeleton organization SREBP signaling pathway regulation of Rho protein signal transduction positive regulation of GTPase activity positive regulation of stress fiber assembly uc008vmy.1 uc008vmy.2 uc008vmy.3 uc008vmy.4 
ENSMUST00000069637.15 Zfp277 ENSMUST00000069637.15 zinc finger protein 277, transcript variant 2 (from RefSeq NM_178845.3) E9Q6D6 ENSMUST00000069637.1 ENSMUST00000069637.10 ENSMUST00000069637.11 ENSMUST00000069637.12 ENSMUST00000069637.13 ENSMUST00000069637.14 ENSMUST00000069637.2 ENSMUST00000069637.3 ENSMUST00000069637.4 ENSMUST00000069637.5 ENSMUST00000069637.6 ENSMUST00000069637.7 ENSMUST00000069637.8 ENSMUST00000069637.9 NM_178845 Q3U0V6 Q3UM86 Q80UK2 Q8BVL5 Q8BVX7 ZN277_MOUSE Zfp277 Znf277 uc007nlb.1 uc007nlb.2 uc007nlb.3 uc007nlb.4 Probable transcription factor (PubMed:20808772). Involved in modulation of cellular senescence; represses transcription of the tumor suppressor gene INK4A/ARF, perhaps acting via the Polycomb group (PcG) complex PRC1 (PubMed:20808772). Interacts (via zinc-finger domains) with RPS2/40S ribosomal protein S2, perhaps as nascent RPS2 is synthesized during translation; the interaction is direct; the interaction is extra-ribosomal. Interaction with RPS2 competes with the binding of RPS2 to protein arginine methyltransferase PRMT3 (By similarity). Interacts with Polycomb group (PcG) complex protein BMI1 (PubMed:20808772). May be part of a complex including at least ZNF277, BMI1 and RNF2/RING2 (PubMed:20808772). Nucleus Cytoplasm Nucleus, nucleolus Chromosome Note=Probably localized to nucleolus and cytoplasm in complex with 40S ribosomal protein S2/RPS2. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q6D6-1; Sequence=Displayed; Name=2; IsoId=E9Q6D6-2; Sequence=VSP_061466; Down-regulated by oxidative stress. Belongs to the ZNF277 family. RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleic acid binding protein binding cellular_component cellular response to hydrogen peroxide regulation of cellular senescence uc007nlb.1 uc007nlb.2 uc007nlb.3 uc007nlb.4 
ENSMUST00000069649.9 Abhd16b ENSMUST00000069649.9 abhydrolase domain containing 16B (from RefSeq NM_183181.2) ABHGB_MOUSE Abhd16b ENSMUST00000069649.1 ENSMUST00000069649.2 ENSMUST00000069649.3 ENSMUST00000069649.4 ENSMUST00000069649.5 ENSMUST00000069649.6 ENSMUST00000069649.7 ENSMUST00000069649.8 NM_183181 Q80YU0 uc008omj.1 uc008omj.2 uc008omj.3 Belongs to the AB hydrolase superfamily. ABHD16 family. molecular_function cellular_component biological_process hydrolase activity uc008omj.1 uc008omj.2 uc008omj.3 
ENSMUST00000069652.8 Rab3gap2 ENSMUST00000069652.8 RAB3 GTPase activating protein subunit 2, transcript variant 3 (from RefSeq NR_175935.1) E9QKE4 E9QKE4_MOUSE ENSMUST00000069652.1 ENSMUST00000069652.2 ENSMUST00000069652.3 ENSMUST00000069652.4 ENSMUST00000069652.5 ENSMUST00000069652.6 ENSMUST00000069652.7 NR_175935 Rab3gap2 uc007dyu.1 uc007dyu.2 uc007dyu.3 uc007dyu.4 Cytoplasm Belongs to the Rab3-GAP regulatory subunit family. cytosol plasma membrane Rab guanyl-nucleotide exchange factor activity Rab GTPase binding macromolecular complex regulation of GTPase activity establishment of protein localization to endoplasmic reticulum membrane positive regulation of protein lipidation positive regulation of endoplasmic reticulum tubular network organization positive regulation of autophagosome assembly uc007dyu.1 uc007dyu.2 uc007dyu.3 uc007dyu.4 
ENSMUST00000069674.6 Tmem69 ENSMUST00000069674.6 transmembrane protein 69 (from RefSeq NM_177670.4) A2ACZ7 ENSMUST00000069674.1 ENSMUST00000069674.2 ENSMUST00000069674.3 ENSMUST00000069674.4 ENSMUST00000069674.5 NM_177670 Q3KQJ0 Q8C9K2 TMM69_MOUSE uc012djj.1 uc012djj.2 uc012djj.3 Membrane ; Multi-pass membrane protein Sequence=BAC31112.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc012djj.1 uc012djj.2 uc012djj.3 
ENSMUST00000069695.9 Tmem150a ENSMUST00000069695.9 transmembrane protein 150A (from RefSeq NM_144916.3) ENSMUST00000069695.1 ENSMUST00000069695.2 ENSMUST00000069695.3 ENSMUST00000069695.4 ENSMUST00000069695.5 ENSMUST00000069695.6 ENSMUST00000069695.7 ENSMUST00000069695.8 NM_144916 Q91WN2 T150A_MOUSE Tmem150 uc009cih.1 uc009cih.2 uc009cih.3 Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex. Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (By similarity). May also play a role in fasting-induced catabolism (By similarity). Interacts (via C-terminal cytoplasmic tail) with PI4KA. Cell membrane ; Multi-pass membrane protein Note=Localizes mainly at the plasma membrane; only a minor fraction localizes on intracellular structures. Belongs to the DRAM/TMEM150 family. molecular_function lysosome plasma membrane integral component of plasma membrane catabolic process regulation of autophagy membrane integral component of membrane phosphatidylinositol phosphorylation protein localization to plasma membrane uc009cih.1 uc009cih.2 uc009cih.3 
ENSMUST00000069718.15 Fto ENSMUST00000069718.15 FTO alpha-ketoglutarate dependent dioxygenase (from RefSeq NM_011936.2) ENSMUST00000069718.1 ENSMUST00000069718.10 ENSMUST00000069718.11 ENSMUST00000069718.12 ENSMUST00000069718.13 ENSMUST00000069718.14 ENSMUST00000069718.2 ENSMUST00000069718.3 ENSMUST00000069718.4 ENSMUST00000069718.5 ENSMUST00000069718.6 ENSMUST00000069718.7 ENSMUST00000069718.8 ENSMUST00000069718.9 FTO_MOUSE Fto Kiaa1752 NM_011936 Q3TTZ5 Q6ZPI7 Q8BGW1 Q8BR68 Q8CB66 Q8R250 Q9QZ13 uc009mst.1 uc009mst.2 uc009mst.3 uc009mst.4 RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:17991826, PubMed:18775698, PubMed:28002401). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:28002401). M6A demethylation by FTO affects mRNA expression and stability (By similarity). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (By similarity). Mediates demethylation of N(6),2'- O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)- methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (By similarity). Also acts as a tRNA demethylase by removing N(1)- methyladenine from various tRNAs (By similarity). Has no activity towards 1-methylguanine (By similarity). Has no detectable activity towards double-stranded DNA (By similarity). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single- stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single- stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:17991826, PubMed:18775698). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:17991826, PubMed:18775698). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:19234441, PubMed:19680540, PubMed:21076408, PubMed:23817550, PubMed:23300482). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:19234441, PubMed:19680540). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (PubMed:23817550). Reaction=2-oxoglutarate + a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:57896, Rhea:RHEA-COMP:11518, Rhea:RHEA-COMP:11519, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:85958, ChEBI:CHEBI:85959; Evidence=; Reaction=2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:49520, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=1.14.11.53; Evidence=; Reaction=2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 = adenosine in U6 snRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:57900, Rhea:RHEA-COMP:13573, Rhea:RHEA-COMP:13574, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; Evidence=; Reaction=2-oxoglutarate + a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:57904, Rhea:RHEA-COMP:15030, Rhea:RHEA-COMP:15031, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:85958, ChEBI:CHEBI:85959; Evidence=; Reaction=2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 = an adenosine in tRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:54576, Rhea:RHEA-COMP:10242, Rhea:RHEA-COMP:12312, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Activated by ascorbate (PubMed:17991826). Inhibited by N-oxalylglycine, fumarate and succinate (PubMed:17991826). pH dependence: Optimum pH is 5.5-6. ; Monomer (PubMed:19680540). May also exist as homodimer (PubMed:19680540). Nucleus cleus speckle Cytoplasm Note=Localizes mainly in the nucleus, where it is able to demethylate N(6)-methyladenosine (m6A) and N(6),2'- O-dimethyladenosine cap (m6A(m)) in U6 small nuclear RNA (snRNA), N(1)- methyladenine from tRNAs and internal m6A in mRNAs. In the cytoplasm, mediates demethylation of m6A and m6A(m) in mRNAs and N(1)- methyladenine from tRNAs. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BGW1-1; Sequence=Displayed; Name=2; IsoId=Q8BGW1-2; Sequence=VSP_025011; Name=3; IsoId=Q8BGW1-3; Sequence=VSP_025009, VSP_025010; Name=4; IsoId=Q8BGW1-4; Sequence=VSP_025007, VSP_025008; Ubiquitous. Detected in brain, brain cortex, hypothalamus, cerebellum, liver, pancreas, heart, kidney, white adipose tissue and skeletal muscle. Most abundant in the brain, particularly in hypothalamic nuclei governing energy balance. Down-regulated in fasting animals. The 3D-structure of the Fe2OG dioxygenase domain is similar to that of the Fe2OG dioxygenase domain found in the bacterial DNA repair dioxygenase alkB and its mammalian orthologs, but sequence similarity is very low. As a consequence, the domain is not detected by protein signature databases. Elevated perinatal mortality (PubMed:19234441). Mice have normal body weight at birth, but show growth retardation from day 2 onwards, resulting in a weight reduction of 30-40% after 6 weeks, both in males and females (PubMed:19234441). In addition, animals display reduced nose to anus length (PubMed:19234441). Fat mass is reduced by 60% in males and by 23% in females (PubMed:19234441). Lean body mass is reduced by 26% in males and 19% in females (PubMed:19234441). White adipose tissue decreases more and more over time, while brown adipose tissue is not affected (PubMed:19234441). Serum leptin levels are decreased, while serum levels of adiponectin are increased (PubMed:19234441). Mice exhibit significant hyperphagia after correction for body weight (PubMed:19234441). They show increased oxygen consumption, carbon dioxide production and heat generation, indicating increased energy expenditure, in spite of reduced spontaneous locomotor activity (PubMed:19234441). Plasma adrenaline concentrations are significantly increased (PubMed:19234441). Overall glucose metabolism appears normal (PubMed:19234441). Conditional deletion in the adult affects body composition and metabolism, and causes a small reduction in food intake and weight gain (PubMed:23300482). Mice with conditional deletion in dopaminergic neurons show abnormal dopamine signaling pathways, including impaired dopamine receptor type 2 (D2R) and type 3 (D3R) signaling and the related locomotion function (PubMed:23817550). Deficient mice show increased N(6)-methyladenosine (m6A) in a subset of mRNAs important for neuronal signaling, including many in the dopaminergic signaling pathway (PubMed:23817550). Knockout cells show strongly increased levels of N(6),2'-O-dimethyladenosine cap (m6A(m)) mRNAs (PubMed:28002401). Belongs to the fto family. Many publications have reported a critical role of Fto in regulating fat mass, adipogenesis and total body weight (PubMed:19234441, PubMed:19680540, PubMed:21076408, PubMed:23817550, PubMed:23300482). However, some reports suggest that some effects are indirect and caused by impaired expression of adjacent genes such as Irx3 and Rpgrip1l (PubMed:24807221, PubMed:24646999). Sequence=BAC98247.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; temperature homeostasis nucleus cytoplasm DNA dealkylation involved in DNA repair ferrous iron binding regulation of lipid storage oxidoreductase activity nuclear speck oxidative RNA demethylase activity oxidative DNA demethylase activity oxidative single-stranded DNA demethylation oxidative single-stranded RNA demethylation regulation of multicellular organism growth RNA repair DNA-N1-methyladenine dioxygenase activity regulation of respiratory system process metal ion binding dioxygenase activity oxidation-reduction process adipose tissue development mRNA destabilization regulation of white fat cell proliferation oxidative demethylation DNA demethylation regulation of brown fat cell differentiation RNA N6-methyladenosine dioxygenase activity tRNA demethylase activity uc009mst.1 uc009mst.2 uc009mst.3 uc009mst.4 
ENSMUST00000069741.4 E130018O15Rik ENSMUST00000069741.4 RIKEN cDNA E130018O15 gene (from RefSeq NR_152157.1) ENSMUST00000069741.1 ENSMUST00000069741.2 ENSMUST00000069741.3 NR_152157 uc008xdr.1 uc008xdr.2 uc008xdr.3 uc008xdr.1 uc008xdr.2 uc008xdr.3 
ENSMUST00000069742.8 Prr18 ENSMUST00000069742.8 proline rich 18, transcript variant 2 (from RefSeq NM_001399587.1) ENSMUST00000069742.1 ENSMUST00000069742.2 ENSMUST00000069742.3 ENSMUST00000069742.4 ENSMUST00000069742.5 ENSMUST00000069742.6 ENSMUST00000069742.7 NM_001399587 PRR18_MOUSE Q6PAN7 Q8BR84 Q8CA32 Q8CBI5 uc008ajo.1 uc008ajo.2 uc008ajo.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PAN7-1; Sequence=Displayed; Name=2; IsoId=Q6PAN7-2; Sequence=VSP_028816; Sequence=BAC29250.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc008ajo.1 uc008ajo.2 uc008ajo.3 
ENSMUST00000069747.6 Emc7 ENSMUST00000069747.6 ER membrane protein complex subunit 7 (from RefSeq NM_133749.2) EMC7_MOUSE ENSMUST00000069747.1 ENSMUST00000069747.2 ENSMUST00000069747.3 ENSMUST00000069747.4 ENSMUST00000069747.5 NM_133749 Orf3 Q9EP72 uc056zoh.1 uc056zoh.2 uc056zoh.3 Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N- exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Component of the ER membrane protein complex (EMC). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Belongs to the EMC7 family. molecular_function biological_process membrane integral component of membrane carbohydrate binding ER membrane protein complex uc056zoh.1 uc056zoh.2 uc056zoh.3 
ENSMUST00000069756.11 Ocln ENSMUST00000069756.11 occludin, transcript variant 1 (from RefSeq NM_008756.2) ENSMUST00000069756.1 ENSMUST00000069756.10 ENSMUST00000069756.2 ENSMUST00000069756.3 ENSMUST00000069756.4 ENSMUST00000069756.5 ENSMUST00000069756.6 ENSMUST00000069756.7 ENSMUST00000069756.8 ENSMUST00000069756.9 NM_008756 OCLN_MOUSE Ocl Q544A7 Q61146 uc007rqy.1 uc007rqy.2 uc007rqy.3 May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Interacts with TJP1/ZO1. Interacts with VAPA. Interacts with CLDN1, CLDN6, CLDN9, CLDN11, CLDN12 and CLDN17. Interacts with PLSCR1. Interacts with LSR, ILDR1 and ILDR2. Interacts with TJP2/ZO2 (PubMed:10026224). Cell membrane ; Multi-pass membrane protein Cell junction, tight junction Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in the testis, kidney, lung, liver and brain. Not detected in skeletal muscle, spleen and heart. Found diffusely on the lateral membranes of Sertoli cells in the early prepubertal period. With development, became gradually concentrated at the most basal regions of Sertoli cells. The C-terminal is cytoplasmic and is important for interaction with ZO-1. Necessary for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction (By similarity). Dephosphorylated by PTPRJ (By similarity). May be phosphorylated by PKC during translocation to cell-cell contacts. Mice have a complex phenotype including abnormalities of salivary gland, gastric epithelium, bone, testis and intracranial calcification. Belongs to the ELL/occludin family. protein binding plasma membrane cell-cell junction bicellular tight junction cell surface membrane integral component of membrane apical plasma membrane apicolateral plasma membrane lateral plasma membrane protein domain specific binding cell junction endocytic vesicle cytoplasmic vesicle macromolecular complex cell-cell junction organization response to interleukin-18 bicellular tight junction assembly cellular response to tumor necrosis factor uc007rqy.1 uc007rqy.2 uc007rqy.3 
ENSMUST00000069760.13 Oosp3 ENSMUST00000069760.13 oocyte secreted protein 3 (from RefSeq NM_001033283.2) B9EIY2 ENSMUST00000069760.1 ENSMUST00000069760.10 ENSMUST00000069760.11 ENSMUST00000069760.12 ENSMUST00000069760.2 ENSMUST00000069760.3 ENSMUST00000069760.4 ENSMUST00000069760.5 ENSMUST00000069760.6 ENSMUST00000069760.7 ENSMUST00000069760.8 ENSMUST00000069760.9 G5E8D7 NM_001033283 OOSP3_MOUSE Oosp3 uc008gsv.1 uc008gsv.2 Secreted Oocyte-specific. Belongs to the PLAC1 family. molecular_function cellular_component extracellular region biological_process uc008gsv.1 uc008gsv.2 
ENSMUST00000069763.3 Lancl3 ENSMUST00000069763.3 LanC lantibiotic synthetase component C-like 3 (bacterial) (from RefSeq NM_173414.3) A2AFA5 ENSMUST00000069763.1 ENSMUST00000069763.2 LANC3_MOUSE NM_173414 Q14BF1 Q8BRA2 Q8BRN8 Q8CD19 uc009spo.1 uc009spo.2 uc009spo.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CD19-1; Sequence=Displayed; Name=2; IsoId=Q8CD19-2; Sequence=VSP_024856; Belongs to the LanC-like protein family. Sequence=BAC32282.1; Type=Frameshift; Evidence=; molecular_function catalytic activity plasma membrane uc009spo.1 uc009spo.2 uc009spo.3 
ENSMUST00000069772.16 Tmem143 ENSMUST00000069772.16 transmembrane protein 143 (from RefSeq NM_144801.2) ENSMUST00000069772.1 ENSMUST00000069772.10 ENSMUST00000069772.11 ENSMUST00000069772.12 ENSMUST00000069772.13 ENSMUST00000069772.14 ENSMUST00000069772.15 ENSMUST00000069772.2 ENSMUST00000069772.3 ENSMUST00000069772.4 ENSMUST00000069772.5 ENSMUST00000069772.6 ENSMUST00000069772.7 ENSMUST00000069772.8 ENSMUST00000069772.9 G3X9F4 G3X9F4_MOUSE NM_144801 Tmem143 uc009gxs.1 uc009gxs.2 uc009gxs.3 uc009gxs.4 mitochondrion membrane integral component of membrane uc009gxs.1 uc009gxs.2 uc009gxs.3 uc009gxs.4 
ENSMUST00000069782.11 Dglucy ENSMUST00000069782.11 D-glutamate cyclase, transcript variant 3 (from RefSeq NM_145448.5) ENSMUST00000069782.1 ENSMUST00000069782.10 ENSMUST00000069782.2 ENSMUST00000069782.3 ENSMUST00000069782.4 ENSMUST00000069782.5 ENSMUST00000069782.6 ENSMUST00000069782.7 ENSMUST00000069782.8 ENSMUST00000069782.9 GLUCM_MOUSE NM_145448 Q8BH86 Q8BNN0 Q8VC99 uc007osw.1 uc007osw.2 uc007osw.3 D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. Reaction=D-glutamate = 5-oxo-D-proline + H2O; Xref=Rhea:RHEA:22360, ChEBI:CHEBI:15377, ChEBI:CHEBI:29986, ChEBI:CHEBI:57948; EC=4.2.1.48; Evidence=; Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BH86-1; Sequence=Displayed; Name=2; IsoId=Q8BH86-2; Sequence=VSP_010512, VSP_010513; Accumulation of D-glutamate in heart. Mice develop normally and do not display any visible phenotype under normal conditions. Belongs to the D-glutamate cyclase family. mitochondrion mitochondrial matrix glutamate metabolic process lyase activity D-glutamate cyclase activity uc007osw.1 uc007osw.2 uc007osw.3 
ENSMUST00000069789.12 Lep ENSMUST00000069789.12 leptin (from RefSeq NM_008493.3) ENSMUST00000069789.1 ENSMUST00000069789.10 ENSMUST00000069789.11 ENSMUST00000069789.2 ENSMUST00000069789.3 ENSMUST00000069789.4 ENSMUST00000069789.5 ENSMUST00000069789.6 ENSMUST00000069789.7 ENSMUST00000069789.8 ENSMUST00000069789.9 Lep NM_008493 Q544U0 Q544U0_MOUSE uc009bcv.1 uc009bcv.2 uc009bcv.3 Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up- regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation. Secreted Belongs to the leptin family. angiogenesis ovulation from ovarian follicle response to hypoxia positive regulation of cytokine production placenta development regulation of endothelial cell proliferation response to dietary excess cardiac muscle hypertrophy receptor binding hormone activity extracellular region extracellular space energy reserve metabolic process glycerol biosynthetic process phagocytosis signal transduction female pregnancy response to nutrient circadian rhythm regulation of blood pressure positive regulation of cell proliferation fatty acid catabolic process negative regulation of metabolic process negative regulation of autophagy negative regulation of lipid storage positive regulation of phosphatidylinositol 3-kinase signaling response to activity sexual reproduction response to nutrient levels positive regulation of TOR signaling prostaglandin secretion response to estradiol regulation of natural killer cell activation regulation of natural killer cell proliferation response to vitamin E leptin-mediated signaling pathway positive regulation of luteinizing hormone secretion positive regulation of peroxisome proliferator activated receptor signaling pathway intracellular signal transduction bone mineralization involved in bone maturation negative regulation of appetite by leptin-mediated signaling pathway positive regulation of T cell proliferation regulation of natural killer cell mediated cytotoxicity positive regulation of tyrosine phosphorylation of STAT protein negative regulation of apoptotic process positive regulation of ion transport positive regulation of MAPK cascade cellular response to leptin stimulus response to ethanol regulation of angiogenesis negative regulation of vasoconstriction negative regulation of glucose import positive regulation of JAK-STAT cascade positive regulation of insulin receptor signaling pathway positive regulation of follicle-stimulating hormone secretion positive regulation of developmental growth intestinal absorption leukocyte tethering or rolling regulation of nitric-oxide synthase activity peptide hormone receptor binding regulation of cell cycle regulation of lipoprotein lipid oxidation negative regulation of cartilage development cellular response to L-ascorbic acid cellular response to retinoic acid interleukin-6 secretion interleukin-8 secretion regulation of cytokine production involved in inflammatory response positive regulation of p38MAPK cascade positive regulation of fat cell apoptotic process activation of protein kinase C activity positive regulation of reactive oxygen species metabolic process negative regulation of glutamine transport positive regulation of hepatic stellate cell activation uc009bcv.1 uc009bcv.2 uc009bcv.3 
ENSMUST00000069790.5 Or1e19 ENSMUST00000069790.5 olfactory receptor family 1 subfamily E member 19 (from RefSeq NM_147024.2) ENSMUST00000069790.1 ENSMUST00000069790.2 ENSMUST00000069790.3 ENSMUST00000069790.4 NM_147024 Olfr378 Or1e19 Q8VGT2 Q8VGT2_MOUSE uc007kat.1 uc007kat.2 uc007kat.3 uc007kat.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DR065651.1, DR065676.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007kat.1 uc007kat.2 uc007kat.3 uc007kat.4 
ENSMUST00000069792.14 Nab1 ENSMUST00000069792.14 Ngfi-A binding protein 1, transcript variant 1 (from RefSeq NM_008667.4) ENSMUST00000069792.1 ENSMUST00000069792.10 ENSMUST00000069792.11 ENSMUST00000069792.12 ENSMUST00000069792.13 ENSMUST00000069792.2 ENSMUST00000069792.3 ENSMUST00000069792.4 ENSMUST00000069792.5 ENSMUST00000069792.6 ENSMUST00000069792.7 ENSMUST00000069792.8 ENSMUST00000069792.9 NAB1_MOUSE NM_008667 Q61122 Q99J24 uc007ayh.1 uc007ayh.2 uc007ayh.3 uc007ayh.4 Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Homomultimers may associate with EGR1 bound to DNA. Nucleus Widely expressed in adult. In day 16 embryo highest levels in forebrain, thymus, salivary gland and cartilage. In day 16 embryo highest levels in forebrain, thymus, salivary gland and cartilage. The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization. The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression. Belongs to the NAB family. endochondral ossification transcription cofactor activity nucleus regulation of transcription, DNA-templated transcription factor binding Schwann cell differentiation myelination regulation of epidermis development negative regulation of transcription, DNA-templated uc007ayh.1 uc007ayh.2 uc007ayh.3 uc007ayh.4 
ENSMUST00000069799.3 Irs1 ENSMUST00000069799.3 insulin receptor substrate 1 (from RefSeq NM_010570.4) ENSMUST00000069799.1 ENSMUST00000069799.2 Irs1 NM_010570 Q543V3 Q543V3_MOUSE uc007brp.1 uc007brp.2 uc007brp.3 uc007brp.4 phosphotyrosine binding SH3/SH2 adaptor activity insulin receptor binding insulin-like growth factor receptor binding nucleus cytosol plasma membrane caveola insulin receptor signaling pathway positive regulation of glucose metabolic process phosphatidylinositol 3-kinase signaling positive regulation of fatty acid beta-oxidation response to insulin cellular response to insulin stimulus phosphatidylinositol 3-kinase binding positive regulation of glycogen biosynthetic process positive regulation of glucose import positive regulation of insulin receptor signaling pathway negative regulation of insulin secretion insulin-like growth factor receptor signaling pathway uc007brp.1 uc007brp.2 uc007brp.3 uc007brp.4 
ENSMUST00000069800.6 Fut2 ENSMUST00000069800.6 fucosyltransferase 2, transcript variant 2 (from RefSeq NM_018876.4) ENSMUST00000069800.1 ENSMUST00000069800.2 ENSMUST00000069800.3 ENSMUST00000069800.4 ENSMUST00000069800.5 FUT2_MOUSE Fut2 NM_018876 O70504 Q9JL27 Sec2 uc009gwn.1 uc009gwn.2 uc009gwn.3 This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N- linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:11018479, PubMed:11368156, PubMed:14967068, PubMed:11323419, PubMed:27161092, PubMed:19706747). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (PubMed:11713270, PubMed:14967068). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:27161092, PubMed:19706747). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:11323419). Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal- (1->3)-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:50664, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133506, ChEBI:CHEBI:133509; EC=2.4.1.69; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50665; Evidence=; Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal- (1->4)-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:50668, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133507, ChEBI:CHEBI:133510; EC=2.4.1.344; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50669; Evidence=; Reaction=a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+); Xref=Rhea:RHEA:48800, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90376, ChEBI:CHEBI:90803; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48801; Evidence=; Reaction=a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+); Xref=Rhea:RHEA:48304, ChEBI:CHEBI:15378, ChEBI:CHEBI:17006, ChEBI:CHEBI:28691, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48305; Evidence=; Reaction=a ganglioside GM1 + GDP-beta-L-fucose = a ganglioside Fuc-GM1 + GDP + H(+); Xref=Rhea:RHEA:48292, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:82639, ChEBI:CHEBI:90189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48293; Evidence=; Reaction=a ganglioside GA1 + GDP-beta-L-fucose = a ganglioside Fuc-GA1 + GDP + H(+); Xref=Rhea:RHEA:48320, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:88069, ChEBI:CHEBI:90262; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48321; Evidence=; Reaction=GDP-beta-L-fucose + Lc4Cer = alpha-L-fucosyl-(1->2)-beta-D- galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+); Xref=Rhea:RHEA:48792, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90800, ChEBI:CHEBI:90802; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48793; Evidence=; Reaction=a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)- beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = alpha-L- fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D- glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1')-N-acylsphing-4-enine + GDP + H(+); Xref=Rhea:RHEA:32175, ChEBI:CHEBI:15378, ChEBI:CHEBI:17292, ChEBI:CHEBI:28743, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189; EC=2.4.1.69; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32176; Evidence=; Reaction=a ganglioside GD1b + GDP-beta-L-fucose = a ganglioside Fuc- GD1b + GDP + H(+); Xref=Rhea:RHEA:48324, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:82939, ChEBI:CHEBI:90265; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48325; Evidence=; Reaction=a ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = a ganglioside Fuc-GM1 (d18:1(4E)) + GDP + H(+); Xref=Rhea:RHEA:42040, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:77709, ChEBI:CHEBI:78607; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42041; Evidence=; Reaction=a globoside GalGb4Cer (d18:1(4E)) + GDP-beta-L-fucose = a globoside Globo-H (d18:1(4E)) + GDP + H(+); Xref=Rhea:RHEA:42044, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:62571, ChEBI:CHEBI:62649; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42045; Evidence=; Reaction=a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+); Xref=Rhea:RHEA:62616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90811, ChEBI:CHEBI:142612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62617; Evidence=; Reaction=beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta- L-fucose = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl- D-galactosamine + GDP + H(+); Xref=Rhea:RHEA:62964, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:84728, ChEBI:CHEBI:546807; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62965; Evidence=; Kinetic parameters: KM=10.2 mM for phenyl-beta-D-galactoside ; KM=54.73 mM for phenyl-beta-D-galactoside ; KM=36.46 mM for lactose ; KM=50 uM for ganglioside GA1 ; KM=500 uM for ganglioside GM1a ; KM=166 uM for nLc4Cer ; KM=95 uM for Lc4Cer ; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Note=Membrane-bound form in trans cisternae of Golgi. Expressed in stomach, colon, ovary and uterus, specifically in luminal uterine epithelium (PubMed:11323419, PubMed:11368156). Expressed in various tissues including heart, liver, kidney, testis, epididymis, small intestine,and cecum (PubMed:11368156). Expressed in duodenum, jejunum and ileum (PubMed:14967068). Detected at highest levels in proestrus and estrus, with 10- to 12-fold increases over early diestrus. Induced after microbes administration in the intestinal epithelia, particularly in the duodenal and jejunal epithelia (PubMed:11368156, PubMed:14967068). Down-regulated by androgen in the caput epididymis (PubMed:24284406). Homozygous knockout mice for FUT2 are fertiles and develop normally and exhibit no gross phenotypic abnormalities. In mouse, there are three genes (Fut1, Fut2 and Sec1) which encode galactoside 2-L-fucosyltransferase. Belongs to the glycosyltransferase 11 family. Name=Functional Glycomics Gateway - GTase; Note=Fucosyltransferase 2; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_612"; Golgi apparatus carbohydrate metabolic process protein glycosylation galactoside 2-alpha-L-fucosyltransferase activity fucosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups Golgi cisterna membrane fucosylation uc009gwn.1 uc009gwn.2 uc009gwn.3 
ENSMUST00000069803.5 Tmsb15b2 ENSMUST00000069803.5 thymosin beta 15b2 (from RefSeq NM_001080967.4) A2AF31 A2AF31_MOUSE ENSMUST00000069803.1 ENSMUST00000069803.2 ENSMUST00000069803.3 ENSMUST00000069803.4 NM_001080967 Tmsb15b2 uc009ujg.1 uc009ujg.2 uc009ujg.3 uc009ujg.4 This gene is part of tandem duplication; the other copy of this gene is about 1.5 kb away. Readthrough transcripts that include two exons transcribed from each gene exist. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CN842750.1, BX638998.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Cytoplasm, cytoskeleton Belongs to the thymosin beta family. stress fiber actin binding actin monomer binding cytoplasm cytoskeleton actin filament organization negative regulation of actin filament polymerization filamentous actin sequestering of actin monomers negative regulation of stress fiber assembly uc009ujg.1 uc009ujg.2 uc009ujg.3 uc009ujg.4 
ENSMUST00000069828.10 Thsd1 ENSMUST00000069828.10 thrombospondin, type I, domain 1, transcript variant 1 (from RefSeq NM_019576.2) A0A0R4J0U4 A0A0R4J0U4_MOUSE ENSMUST00000069828.1 ENSMUST00000069828.2 ENSMUST00000069828.3 ENSMUST00000069828.4 ENSMUST00000069828.5 ENSMUST00000069828.6 ENSMUST00000069828.7 ENSMUST00000069828.8 ENSMUST00000069828.9 NM_019576 Thsd1 uc009lcv.1 uc009lcv.2 uc009lcv.3 uc009lcv.4 uc009lcv.5 cytosol membrane integral component of membrane uc009lcv.1 uc009lcv.2 uc009lcv.3 uc009lcv.4 uc009lcv.5 
ENSMUST00000069837.4 Slit3 ENSMUST00000069837.4 slit guidance ligand 3 (from RefSeq NM_011412.3) B1ATW4 ENSMUST00000069837.1 ENSMUST00000069837.2 ENSMUST00000069837.3 NM_011412 Q9WVB4 SLIT3_MOUSE uc007ild.1 uc007ild.2 uc007ild.3 uc007ild.4 May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors. Secreted Detected as early as 8.25 dpc in the ventral neural tube. From 9.5 dpc to 11.5 dpc is expressed in the floor plate and motor columns. This pattern of expression continued until at least 17.5 dpc and remained weak. Rostrally, at 8.25 dpc is expressed in the ventral midline of the neural groove and in the neural fold prior to closure of the neural tube. Between 8.5 dpc and 9.5 dpc, expression is observed in the ventral side of the mesencephalon and metencephalon and in the commissural plate after closure of the neural tube. After 13.5 dpc, the expression of SLIT3 is weak in the developing CNS. At 9.5 dpc, SLIT3 is detected in the otic vesicle and in the clefts between the first and the second branchial arches. Between 10.5 dpc and 11.5 dpc is prominently expressed in the otic vesicle but decreased in the branchial clefts. From 13.5 dpc to 17.5 dpc, expression is observed in the cochlea, in the pigment layer of the retina, and in the olfactory epithelium. At 13.5 dpc expression is observed in the whisker follicle surrounding the bulb and shaft. In the developing limb is first detected at 10.5 dpc in distal limb bud mesenchyme. At this stage, is also observed in lateral ridge tissue flanking the limb bud. This pattern persisted through 11.5 dpc but unlike with SLIT2, expression is not observed in the inter-limb bud lateral ridge tissue. At 11.5 dpc, expression in both the fore- and the hindlimb is most intense in the distal anterior mesenchyme and in the proximal posterior cleft between the limb bud and the lateral ridge. At 13.5 dpc could be detected in the wrist and weakly in palm and proximal part of the digits excluding the tips of the digits. aortic valve morphogenesis atrioventricular valve morphogenesis receptor binding calcium ion binding extracellular region extracellular space plasma membrane multicellular organism development nervous system development axon guidance heparin binding negative regulation of cell proliferation animal organ morphogenesis negative regulation of gene expression membrane cell differentiation negative regulation of cell growth cellular response to hormone stimulus Roundabout signaling pathway Roundabout binding axon extension involved in axon guidance negative chemotaxis response to cortisol ventricular septum morphogenesis apoptotic process involved in luteolysis negative regulation of chemokine-mediated signaling pathway mitochondrion uc007ild.1 uc007ild.2 uc007ild.3 uc007ild.4 
ENSMUST00000069852.2 Gm11541 ENSMUST00000069852.2 predicted gene 11541 (from RefSeq NR_177955.1) ENSMUST00000069852.1 NR_177955 uc007kzj.1 uc007kzj.2 uc007kzj.1 uc007kzj.2 
ENSMUST00000069862.11 A430033K04Rik ENSMUST00000069862.11 RIKEN cDNA A430033K04 gene (from RefSeq NM_183025.2) A430033K04Rik E9Q8G5 ENSMUST00000069862.1 ENSMUST00000069862.10 ENSMUST00000069862.2 ENSMUST00000069862.3 ENSMUST00000069862.4 ENSMUST00000069862.5 ENSMUST00000069862.6 ENSMUST00000069862.7 ENSMUST00000069862.8 ENSMUST00000069862.9 NM_183025 ObI1 ZFOI1_MOUSE uc009afu.1 uc009afu.2 uc009afu.3 uc009afu.4 uc009afu.5 May modulate osteogenic differentiation, at least in part, through the bone morphogenetic protein (BMP) signaling pathway, increasing RUNX2 activation and leading to osteoblast commitment and maturation. Nucleus Expressed during osteogenic differentiation where levels increase from the first days of differentiation and remain high during the whole process (PubMed:30654721). Highly expressed in lung (PubMed:30654721). Up-regulated during osteogenic differentiation. Polyubiquitinated, leading to its degradation via the ubiquitin- proteasome pathway. nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding negative regulation of transcription, DNA-templated metal ion binding uc009afu.1 uc009afu.2 uc009afu.3 uc009afu.4 uc009afu.5 
ENSMUST00000069912.6 Rgs9bp ENSMUST00000069912.6 regulator of G-protein signalling 9 binding protein (from RefSeq NM_145840.3) ENSMUST00000069912.1 ENSMUST00000069912.2 ENSMUST00000069912.3 ENSMUST00000069912.4 ENSMUST00000069912.5 NM_145840 Q148R9 Q8K462 R9BP_MOUSE R9ap uc009gkb.1 uc009gkb.2 uc009gkb.3 uc009gkb.4 Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation. Specifically interacts with isoform RGS9-1 of RGS9. Interaction is decreased when RGS9-1 is phosphorylated at 'Ser-475'. Component of the RGS9-1-Gbeta5 complex composed of RGS9-1, Gbeta5 (GNB5) and RGS9BP. Membrane ; Single- pass type IV membrane protein Predominantly expressed in photoreceptors of the retina. Weakly expressed in other areas of the central nervous system. Mice show light responses that recover at a abnormally slow rate. Belongs to the RGS7BP/RGS9BP family. photoreceptor outer segment visual perception negative regulation of signal transduction membrane integral component of membrane response to stimulus detection of light stimulus involved in visual perception uc009gkb.1 uc009gkb.2 uc009gkb.3 uc009gkb.4 
ENSMUST00000069926.14 Slitrk4 ENSMUST00000069926.14 SLIT and NTRK-like family, member 4, transcript variant 1 (from RefSeq NM_178740.5) ENSMUST00000069926.1 ENSMUST00000069926.10 ENSMUST00000069926.11 ENSMUST00000069926.12 ENSMUST00000069926.13 ENSMUST00000069926.2 ENSMUST00000069926.3 ENSMUST00000069926.4 ENSMUST00000069926.5 ENSMUST00000069926.6 ENSMUST00000069926.7 ENSMUST00000069926.8 ENSMUST00000069926.9 NM_178740 Q810B8 Q8BL56 Q8BWB0 Q8BYG4 Q8C056 SLIK4_MOUSE uc009tio.1 uc009tio.2 uc009tio.3 It is involved in synaptogenesis and promotes synapse differentiation (By similarity). Suppresses neurite outgrowth (PubMed:14550773). Interacts (via LRR 1 and 2 repeats) with PTPRD (via extracellular domain). Membrane ; Single- pass type I membrane protein Cell membrane In the adult, significant expression is detected only in the brain. Broadly expressed in embryonic brain with highest expression in subventricular zone, subplate, cortical plate, pyramidal cell layer of hippocampus, thalamus and hypothalamus. In the embryo, expressed from day 10-12 and continues through later gestational development and into adulthood. Belongs to the SLITRK family. Sequence=BAC67207.1; Type=Erroneous initiation; Evidence=; protein binding plasma membrane axonogenesis membrane integral component of membrane regulation of synapse organization positive regulation of synapse assembly glutamatergic synapse uc009tio.1 uc009tio.2 uc009tio.3 
ENSMUST00000069927.10 S100a8 ENSMUST00000069927.10 S100 calcium binding protein A8 (calgranulin A) (from RefSeq NM_013650.2) ENSMUST00000069927.1 ENSMUST00000069927.2 ENSMUST00000069927.3 ENSMUST00000069927.4 ENSMUST00000069927.5 ENSMUST00000069927.6 ENSMUST00000069927.7 ENSMUST00000069927.8 ENSMUST00000069927.9 NM_013650 Q53X15 Q53X15_MOUSE S100a8 uc008qdd.1 uc008qdd.2 uc008qdd.3 Belongs to the S-100 family. leukocyte migration involved in inflammatory response calcium ion binding extracellular space cytosol autophagy activation of cysteine-type endopeptidase activity involved in apoptotic process microtubule binding zinc ion binding peptidyl-cysteine S-nitrosylation neutrophil chemotaxis Toll-like receptor 4 binding innate immune response intermediate filament cytoskeleton metal ion binding arachidonic acid binding regulation of inflammatory response positive regulation of inflammatory response RAGE receptor binding neutrophil aggregation positive regulation of intrinsic apoptotic signaling pathway uc008qdd.1 uc008qdd.2 uc008qdd.3 
ENSMUST00000069941.13 Btnl10 ENSMUST00000069941.13 butyrophilin-like 10, transcript variant 1 (from RefSeq NM_001363414.1) A2AB75 BTNLA_MOUSE Butr1 ENSMUST00000069941.1 ENSMUST00000069941.10 ENSMUST00000069941.11 ENSMUST00000069941.12 ENSMUST00000069941.2 ENSMUST00000069941.3 ENSMUST00000069941.4 ENSMUST00000069941.5 ENSMUST00000069941.6 ENSMUST00000069941.7 ENSMUST00000069941.8 ENSMUST00000069941.9 NM_001363414 Q8C0U8 Q9JK39 uc007jco.1 uc007jco.2 uc007jco.3 Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JK39-1; Sequence=Displayed; Name=2; IsoId=Q9JK39-2; Sequence=VSP_043775; Belongs to the immunoglobulin superfamily. BTN/MOG family. receptor binding external side of plasma membrane membrane integral component of membrane regulation of immune response T cell receptor signaling pathway uc007jco.1 uc007jco.2 uc007jco.3 
ENSMUST00000069943.5 Gata5os ENSMUST00000069943.5 GATA binding protein 5, opposite strand (from RefSeq NR_045877.1) ENSMUST00000069943.1 ENSMUST00000069943.2 ENSMUST00000069943.3 ENSMUST00000069943.4 NR_045877 uc029ujg.1 uc029ujg.2 uc029ujg.3 uc029ujg.4 uc029ujg.5 uc029ujg.6 uc029ujg.1 uc029ujg.2 uc029ujg.3 uc029ujg.4 uc029ujg.5 uc029ujg.6 
ENSMUST00000069965.9 Cdk17 ENSMUST00000069965.9 cyclin dependent kinase 17 (from RefSeq NM_146239.2) CDK17_MOUSE ENSMUST00000069965.1 ENSMUST00000069965.2 ENSMUST00000069965.3 ENSMUST00000069965.4 ENSMUST00000069965.5 ENSMUST00000069965.6 ENSMUST00000069965.7 ENSMUST00000069965.8 NM_146239 Pctaire2 Pctk2 Q8K0D0 uc007gul.1 uc007gul.2 uc007gul.3 uc007gul.4 May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K0D0-1; Sequence=Displayed; Name=2; IsoId=Q8K0D0-2; Sequence=VSP_010640, VSP_010641; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Sequence=AAH31778.1; Type=Erroneous initiation; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity regulation of cell cycle uc007gul.1 uc007gul.2 uc007gul.3 uc007gul.4 
ENSMUST00000069992.7 Gm5468 ENSMUST00000069992.7 predicted gene 5468, transcript variant 8 (from RefSeq NR_168943.1) ENSMUST00000069992.1 ENSMUST00000069992.2 ENSMUST00000069992.3 ENSMUST00000069992.4 ENSMUST00000069992.5 ENSMUST00000069992.6 NR_168943 uc288xfu.1 uc288xfu.2 uc288xfu.3 uc288xfu.1 uc288xfu.2 uc288xfu.3 
ENSMUST00000070004.4 Ldhd ENSMUST00000070004.4 lactate dehydrogenase D (from RefSeq NM_027570.5) ENSMUST00000070004.1 ENSMUST00000070004.2 ENSMUST00000070004.3 LDHD_MOUSE Ldhd NM_027570 Q7TNG8 Q8BYU7 Q8CIV4 uc009nmn.1 uc009nmn.2 uc009nmn.3 Involved in D-lactate, but not L-lactate catabolic process. Reaction=(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate; Xref=Rhea:RHEA:13521, Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16004, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.1.2.4; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13522; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Interacts with CSRP3. Mitochondrion Readily detected in liver and kidney, with a weaker signal observed in heart, skeletal muscle, stomach, brain, and lung. Belongs to the FAD-binding oxidoreductase/transferase type 4 family. Sequence=AAM50323.1; Type=Frameshift; Evidence=; Sequence=BAC29917.1; Type=Frameshift; Evidence=; catalytic activity D-lactate dehydrogenase (cytochrome) activity protein binding mitochondrion mitochondrial inner membrane ATP biosynthetic process D-lactate dehydrogenase activity oxidoreductase activity flavin adenine dinucleotide binding oxidation-reduction process FAD binding lactate catabolic process uc009nmn.1 uc009nmn.2 uc009nmn.3 
ENSMUST00000070028.3 Tas2r134 ENSMUST00000070028.3 taste receptor, type 2, member 134 (from RefSeq NM_199158.1) ENSMUST00000070028.1 ENSMUST00000070028.2 NM_199158 Q4VHF1 Q7TQB0 TR134_MOUSE Tas2r34 uc008jqj.1 uc008jqj.2 uc008jqj.3 Putative taste receptor which may play a role in the perception of bitterness. Membrane; Multi-pass membrane protein. Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway taste receptor activity membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc008jqj.1 uc008jqj.2 uc008jqj.3 
ENSMUST00000070048.5 Gm9991 ENSMUST00000070048.5 Gm9991 (from geneSymbol) AK039913 ENSMUST00000070048.1 ENSMUST00000070048.2 ENSMUST00000070048.3 ENSMUST00000070048.4 uc287kif.1 uc287kif.2 uc287kif.3 uc287kif.1 uc287kif.2 uc287kif.3 
ENSMUST00000070059.5 Unc93a2 ENSMUST00000070059.5 unc-93 homolog A2 (from RefSeq NM_001142539.1) B2RWK3 B2RWK3_MOUSE ENSMUST00000070059.1 ENSMUST00000070059.2 ENSMUST00000070059.3 ENSMUST00000070059.4 Gm9992 NM_001142539 Unc93a Unc93a2 uc012ajn.1 uc012ajn.2 uc012ajn.3 Membrane ; Multi- pass membrane protein Belongs to the unc-93 family. molecular_function plasma membrane biological_process membrane integral component of membrane uc012ajn.1 uc012ajn.2 uc012ajn.3 
ENSMUST00000070064.11 Pgm3 ENSMUST00000070064.11 phosphoglucomutase 3, transcript variant 1 (from RefSeq NM_028352.4) AGM1_MOUSE Agm1 B2RS40 ENSMUST00000070064.1 ENSMUST00000070064.10 ENSMUST00000070064.2 ENSMUST00000070064.3 ENSMUST00000070064.4 ENSMUST00000070064.5 ENSMUST00000070064.6 ENSMUST00000070064.7 ENSMUST00000070064.8 ENSMUST00000070064.9 NM_028352 Pgm-3 Pgm3 Q543F9 Q9CYR6 uc009qxm.1 uc009qxm.2 uc009qxm.3 uc009qxm.4 Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation. Reaction=N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D- glucosamine 6-phosphate; Xref=Rhea:RHEA:23804, ChEBI:CHEBI:57513, ChEBI:CHEBI:57776; EC=5.4.2.3; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2. Belongs to the phosphohexose mutase family. magnesium ion binding phosphoacetylglucosamine mutase activity phosphoglucomutase activity carbohydrate metabolic process UDP-N-acetylglucosamine biosynthetic process protein N-linked glycosylation protein O-linked glycosylation spermatogenesis isomerase activity intramolecular transferase activity, phosphotransferases glucose 1-phosphate metabolic process hemopoiesis metal ion binding organic substance metabolic process uc009qxm.1 uc009qxm.2 uc009qxm.3 uc009qxm.4 
ENSMUST00000070070.8 Dnaja4 ENSMUST00000070070.8 DnaJ heat shock protein family (Hsp40) member A4, transcript variant 2 (from RefSeq NM_021422.4) B2RW09 DNJA4_MOUSE ENSMUST00000070070.1 ENSMUST00000070070.2 ENSMUST00000070070.3 ENSMUST00000070070.4 ENSMUST00000070070.5 ENSMUST00000070070.6 ENSMUST00000070070.7 NM_021422 Q543S9 Q9CTD6 Q9CUD4 Q9JMC3 uc009prl.1 uc009prl.2 uc009prl.3 uc009prl.4 Membrane ; Lipid-anchor Specifically expressed in testis and heart. Sequence=BAB30367.2; Type=Erroneous initiation; Evidence=; ATP binding cytosol protein folding response to heat negative regulation of endothelial cell migration positive regulation of gene expression membrane heat shock protein binding protein refolding metal ion binding unfolded protein binding chaperone binding negative regulation of inclusion body assembly uc009prl.1 uc009prl.2 uc009prl.3 uc009prl.4 
ENSMUST00000070080.6 B4galt6 ENSMUST00000070080.6 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 (from RefSeq NM_019737.2) B4GT6_MOUSE B4galt6 ENSMUST00000070080.1 ENSMUST00000070080.2 ENSMUST00000070080.3 ENSMUST00000070080.4 ENSMUST00000070080.5 NM_019737 Q9WVK5 uc008eeu.1 uc008eeu.2 uc008eeu.3 Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:23882130, PubMed:30114188). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (PubMed:30114188). Reaction=a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D- galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:31495, ChEBI:CHEBI:15378, ChEBI:CHEBI:17950, ChEBI:CHEBI:22801, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914; EC=2.4.1.274; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31496; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Inhibited by EDTA. Protein modification; protein glycosylation. Sphingolipid metabolism. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack. Brain and kidney. Single knockout mice are born normally and grow to adulthood without apparent abnormalities (PubMed:23882130). Decreased glucosylceramide beta-1,4-galactosyltransferase activity seen in the brain of female mice whereas minimal or no reduction in the enzyme activity seen in the male brain (PubMed:23882130). Double knockout mice of B4GALT5 and B4GALT6 genes develop normally during embryogenesis and perinatal stage (PubMed:30114188). However, they show growth retardation and motor deficits with hindlimb dysfunction at 2 weeks of age, and they all die by 4 weeks of age (PubMed:30114188). Axonal and myelin formation are remarkably impaired in the spinal cords and increased immature neurons in the cerebral cortices seen (PubMed:30114188). Glucosylceramide beta-1,4-galactosyltransferase activity and major brain gangliosides are completely absent in the brain (PubMed:30114188). Belongs to the glycosyltransferase 7 family. Name=Functional Glycomics Gateway - GTase; Note=b4GalT6; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_465"; lactosylceramide biosynthetic process cellular_component Golgi apparatus carbohydrate metabolic process protein glycosylation lipid metabolic process sphingolipid metabolic process glycosphingolipid biosynthetic process galactosyltransferase activity UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity ganglioside biosynthetic process via lactosylceramide membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups central nervous system neuron axonogenesis central nervous system myelination sphingolipid biosynthetic process Golgi cisterna membrane neuron maturation metal ion binding uc008eeu.1 uc008eeu.2 uc008eeu.3 
ENSMUST00000070084.11 Ticam2 ENSMUST00000070084.11 TIR domain containing adaptor molecule 2 (from RefSeq NM_173394.3) ENSMUST00000070084.1 ENSMUST00000070084.10 ENSMUST00000070084.2 ENSMUST00000070084.3 ENSMUST00000070084.4 ENSMUST00000070084.5 ENSMUST00000070084.6 ENSMUST00000070084.7 ENSMUST00000070084.8 ENSMUST00000070084.9 NM_173394 Q3U996 Q8BJQ4 TCAM2_MOUSE Tirp Tram uc008evp.1 uc008evp.2 uc008evp.3 uc008evp.4 uc008evp.5 Functions as a sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria. Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs in late endosomes and disrupts the interaction between isoform 1 and TICAM1. Interacts with MYD88; the interaction decreases after IL-18 stimulation in a time-dependent manner. Interacts with IL18R1 and IL18RAP. Interacts with TLR2. Interacts with RAB11FIP2. Cytoplasm Golgi apparatus Cell membrane Early endosome Late endosome Endoplasmic reticulum Cell projection, phagocytic cup Note=Localized to the plasma membrane as a result of myristoylation. The TIR domain mediates the interaction with TRAF6 and MYD88. Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling. Phosphorylated by PRKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation. Tyrosine phosphorylation is inhibited by phosphatase PTPN4. regulation of cytokine production phagocytic cup immune system process interleukin-1 receptor binding protein binding phospholipid binding cytoplasm endosome early endosome late endosome endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus plasma membrane intracellular protein transport ER to Golgi vesicle-mediated transport phagocytosis inflammatory response Golgi organization signal transduction membrane ER to Golgi transport vesicle positive regulation of interferon-gamma production positive regulation of interleukin-6 production negative regulation of toll-like receptor 4 signaling pathway positive regulation of toll-like receptor 4 signaling pathway TRAM-dependent toll-like receptor 4 signaling pathway cell projection regulation of I-kappaB kinase/NF-kappaB signaling innate immune response interleukin-1 receptor complex protein heterodimerization activity defense response to virus response to interleukin-12 cellular response to lipopolysaccharide negative regulation of chemokine (C-C motif) ligand 5 production positive regulation of chemokine (C-C motif) ligand 5 production positive regulation of interleukin-18-mediated signaling pathway regulation of interferon-beta biosynthetic process uc008evp.1 uc008evp.2 uc008evp.3 uc008evp.4 uc008evp.5 
ENSMUST00000070085.7 AI504432 ENSMUST00000070085.7 expressed sequence AI504432 (from RefSeq NR_033498.1) ENSMUST00000070085.1 ENSMUST00000070085.2 ENSMUST00000070085.3 ENSMUST00000070085.4 ENSMUST00000070085.5 ENSMUST00000070085.6 NR_033498 uc008qwq.1 uc008qwq.2 uc008qwq.3 uc008qwq.4 uc008qwq.5 uc008qwq.1 uc008qwq.2 uc008qwq.3 uc008qwq.4 uc008qwq.5 
ENSMUST00000070112.6 Ndufa8 ENSMUST00000070112.6 NADH:ubiquinone oxidoreductase subunit A8 (from RefSeq NM_026703.3) A2AL45 ENSMUST00000070112.1 ENSMUST00000070112.2 ENSMUST00000070112.3 ENSMUST00000070112.4 ENSMUST00000070112.5 NDUA8_MOUSE NM_026703 Q9DCJ5 uc008jlb.1 uc008jlb.2 uc008jlb.3 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Peripheral membrane protein Mitochondrion intermembrane space Mitochondrion Contains four C-X9-C motifs that are predicted to form a helix- coil-helix structure, permitting the formation of intramolecular disulfide bonds. Belongs to the complex I NDUFA8 subunit family. mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial intermembrane space mitochondrial electron transport, NADH to ubiquinone membrane mitochondrial respiratory chain complex I assembly macromolecular complex binding oxidation-reduction process respiratory chain uc008jlb.1 uc008jlb.2 uc008jlb.3 
ENSMUST00000070116.12 Socs6 ENSMUST00000070116.12 suppressor of cytokine signaling 6 (from RefSeq NM_018821.5) Cis4 Cish4 ENSMUST00000070116.1 ENSMUST00000070116.10 ENSMUST00000070116.11 ENSMUST00000070116.2 ENSMUST00000070116.3 ENSMUST00000070116.4 ENSMUST00000070116.5 ENSMUST00000070116.6 ENSMUST00000070116.7 ENSMUST00000070116.8 ENSMUST00000070116.9 NM_018821 Q8VEN5 Q9D2A0 Q9JLY0 SOCS6_MOUSE Socs4 uc008fvf.1 uc008fvf.2 uc008fvf.3 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine- phosphorylated receptor (By similarity). Protein modification; protein ubiquitination. Interacts with KIT (phosphorylated) (By similarity). Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3. Q9JLY0; Q9BYM8: RBCK1; Xeno; NbExp=5; IntAct=EBI-8500205, EBI-2340624; The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. immunological synapse protein binding cytosol phosphatidylinositol 3-kinase complex negative regulation of signal transduction proteasomal protein catabolic process protein ubiquitination intracellular signal transduction regulation of growth regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity negative regulation of T cell activation cellular glucose homeostasis uc008fvf.1 uc008fvf.2 uc008fvf.3 
ENSMUST00000070117.8 Cnot10 ENSMUST00000070117.8 CCR4-NOT transcription complex, subunit 10 (from RefSeq NM_153585.5) CNO10_MOUSE ENSMUST00000070117.1 ENSMUST00000070117.2 ENSMUST00000070117.3 ENSMUST00000070117.4 ENSMUST00000070117.5 ENSMUST00000070117.6 ENSMUST00000070117.7 NM_153585 Q05CH8 Q3TSS4 Q3UDS5 Q80VN2 Q8BH15 Q8CI74 uc009rxq.1 uc009rxq.2 uc009rxq.3 uc009rxq.4 Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity). Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8BH15-1; Sequence=Displayed; Name=2; IsoId=Q8BH15-2; Sequence=VSP_030318; Name=3; IsoId=Q8BH15-3; Sequence=VSP_030320; Name=4; IsoId=Q8BH15-4; Sequence=VSP_030319; Name=5; IsoId=Q8BH15-5; Sequence=VSP_030316, VSP_030317; Name=6; IsoId=Q8BH15-6; Sequence=VSP_030315; Belongs to the CNOT10 family. molecular_function nucleus cytoplasm mRNA catabolic process regulation of translation negative regulation of translation CCR4-NOT complex gene silencing by RNA uc009rxq.1 uc009rxq.2 uc009rxq.3 uc009rxq.4 
ENSMUST00000070124.5 H2ac13 ENSMUST00000070124.5 H2A clustered histone 13 (from RefSeq NM_178182.2) C0HKE9 ENSMUST00000070124.1 ENSMUST00000070124.2 ENSMUST00000070124.3 ENSMUST00000070124.4 H2A1P_MOUSE Hist1h2ap NM_178182 P10812 P22752 Q149U0 Q5SZZ2 uc007prb.1 uc007prb.2 uc007prb.3 uc007prb.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007prb.1 uc007prb.2 uc007prb.3 uc007prb.4 
ENSMUST00000070125.6 Chat ENSMUST00000070125.6 choline acetyltransferase (from RefSeq NM_009891.2) Chat ENSMUST00000070125.1 ENSMUST00000070125.2 ENSMUST00000070125.3 ENSMUST00000070125.4 ENSMUST00000070125.5 NM_009891 Q8BQV2 Q8BQV2_MOUSE uc007syv.1 uc007syv.2 uc007syv.3 Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Reaction=acetyl-CoA + choline = acetylcholine + CoA; Xref=Rhea:RHEA:18821, ChEBI:CHEBI:15354, ChEBI:CHEBI:15355, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.6; Evidence=; Belongs to the carnitine/choline acetyltransferase family. transferase activity transferase activity, transferring acyl groups uc007syv.1 uc007syv.2 uc007syv.3 
ENSMUST00000070132.7 Col8a2 ENSMUST00000070132.7 collagen, type VIII, alpha 2 (from RefSeq NM_199473.3) A3KFY2 CO8A2_MOUSE ENSMUST00000070132.1 ENSMUST00000070132.2 ENSMUST00000070132.3 ENSMUST00000070132.4 ENSMUST00000070132.5 ENSMUST00000070132.6 NM_199473 P25318 Q68ED0 Q6KAQ4 Q6P1C4 uc008utd.1 uc008utd.2 uc008utd.3 Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). Homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrahedron stabilized by central interacting C-terminal NC1 trimers (By similarity). Secreted, extracellular space, extracellular matrix, basement membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P25318-1; Sequence=Displayed; Name=2; IsoId=P25318-2; Sequence=VSP_014975; In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Proteolytically cleaved by neutrophil elastase, in vitro. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. COL8A1(-)/COL8A2(-) mice exhibit decreased proliferation of mesangial cells, reduced phosphorylation of ERK1/2 and increased p27(KIP1) expression. Diabetic COL8A1(-)/COL8A2(-) mice reveal reduced mesangial expansion and cellularity and extracellular matrix expansion. angiogenesis extracellular matrix structural constituent extracellular region collagen trimer basement membrane extracellular space cell adhesion extracellular matrix organization extracellular matrix camera-type eye morphogenesis epithelial cell proliferation uc008utd.1 uc008utd.2 uc008utd.3 
ENSMUST00000070139.9 Cndp1 ENSMUST00000070139.9 carnosine dipeptidase 1 (from RefSeq NM_177450.4) A0A0R4J0V0 A0A0R4J0V0_MOUSE Cndp1 ENSMUST00000070139.1 ENSMUST00000070139.2 ENSMUST00000070139.3 ENSMUST00000070139.4 ENSMUST00000070139.5 ENSMUST00000070139.6 ENSMUST00000070139.7 ENSMUST00000070139.8 NM_177450 uc008fur.1 uc008fur.2 uc008fur.3 uc008fur.4 uc008fur.5 Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; Belongs to the peptidase M20A family. cytosol proteolysis metallopeptidase activity hydrolase activity dipeptidase activity regulation of cellular protein metabolic process metal ion binding uc008fur.1 uc008fur.2 uc008fur.3 uc008fur.4 uc008fur.5 
ENSMUST00000070141.7 Magea8 ENSMUST00000070141.7 MAGE family member A8 (from RefSeq NM_020020.4) ENSMUST00000070141.1 ENSMUST00000070141.2 ENSMUST00000070141.3 ENSMUST00000070141.4 ENSMUST00000070141.5 ENSMUST00000070141.6 Magea8 NM_020020 O89012 O89012_MOUSE uc009url.1 uc009url.2 molecular_function cellular_component biological_process uc009url.1 uc009url.2 
ENSMUST00000070150.11 E130308A19Rik ENSMUST00000070150.11 RIKEN cDNA E130308A19 gene, transcript variant 2 (from RefSeq NM_001015681.2) B1AX79 ENSMUST00000070150.1 ENSMUST00000070150.10 ENSMUST00000070150.2 ENSMUST00000070150.3 ENSMUST00000070150.4 ENSMUST00000070150.5 ENSMUST00000070150.6 ENSMUST00000070150.7 ENSMUST00000070150.8 ENSMUST00000070150.9 K1958_MOUSE NM_001015681 Q8BN62 Q8C4P0 Q8K1X8 uc008tab.1 uc008tab.2 uc008tab.3 uc008tab.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C4P0-1; Sequence=Displayed; Name=2; IsoId=Q8C4P0-2; Sequence=VSP_015147; Sequence=BAC39905.1; Type=Frameshift; Evidence=; biological_process uc008tab.1 uc008tab.2 uc008tab.3 uc008tab.4 
ENSMUST00000070172.6 Snx32 ENSMUST00000070172.6 sorting nexin 32, transcript variant 1 (from RefSeq NM_001024560.3) ENSMUST00000070172.1 ENSMUST00000070172.2 ENSMUST00000070172.3 ENSMUST00000070172.4 ENSMUST00000070172.5 NM_001024560 Q80ZJ7 SNX32_MOUSE Snx6b uc008gds.1 uc008gds.2 uc008gds.3 May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family. endosome cytosol protein transport phosphatidylinositol binding retrograde transport, endosome to Golgi uc008gds.1 uc008gds.2 uc008gds.3 
ENSMUST00000070173.9 Pgpep1 ENSMUST00000070173.9 pyroglutamyl-peptidase I (from RefSeq NM_023217.4) ENSMUST00000070173.1 ENSMUST00000070173.2 ENSMUST00000070173.3 ENSMUST00000070173.4 ENSMUST00000070173.5 ENSMUST00000070173.6 ENSMUST00000070173.7 ENSMUST00000070173.8 NM_023217 PGPI_MOUSE Pgpi Q9ESW8 uc009mbc.1 uc009mbc.2 uc009mbc.3 uc009mbc.4 Removes 5-oxoproline from various penultimate amino acid residues except L-proline. Reaction=Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.; EC=3.4.19.3; Evidence= Monomer. Cytoplasm Belongs to the peptidase C15 family. cytoplasm cytosol proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity pyroglutamyl-peptidase activity uc009mbc.1 uc009mbc.2 uc009mbc.3 uc009mbc.4 
ENSMUST00000070178.5 Tas2r135 ENSMUST00000070178.5 taste receptor, type 2, member 135 (from RefSeq NM_199159.1) B9EII2 B9EII2_MOUSE ENSMUST00000070178.1 ENSMUST00000070178.2 ENSMUST00000070178.3 ENSMUST00000070178.4 NM_199159 Tas2r135 uc009brg.1 uc009brg.2 uc009brg.3 Membrane ulti-pass membrane protein Belongs to the G-protein coupled receptor T2R family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane response to stimulus sensory perception of taste uc009brg.1 uc009brg.2 uc009brg.3 
ENSMUST00000070181.7 Itpkb ENSMUST00000070181.7 inositol 1,4,5-trisphosphate 3-kinase B, transcript variant 3 (from RefSeq NM_001418286.1) B2RXC2 B2RXC2_MOUSE ENSMUST00000070181.1 ENSMUST00000070181.2 ENSMUST00000070181.3 ENSMUST00000070181.4 ENSMUST00000070181.5 ENSMUST00000070181.6 Itpkb NM_001418286 uc007dwg.1 uc007dwg.2 uc007dwg.3 Belongs to the inositol phosphokinase (IPK) family. MAPK cascade nucleotide binding regulation of protein phosphorylation myeloid cell homeostasis ATP binding nucleus cytosol cell surface receptor signaling pathway inositol-1,4,5-trisphosphate 3-kinase activity membrane kinase activity phosphorylation transferase activity T cell differentiation inositol trisphosphate metabolic process inositol phosphate biosynthetic process negative regulation of neutrophil apoptotic process common myeloid progenitor cell proliferation positive thymic T cell selection thymic T cell selection negative regulation of myeloid cell differentiation positive regulation of Ras protein signal transduction positive regulation of alpha-beta T cell differentiation cellular response to calcium ion uc007dwg.1 uc007dwg.2 uc007dwg.3 
ENSMUST00000070189.10 Lrguk ENSMUST00000070189.10 leucine-rich repeats and guanylate kinase domain containing, transcript variant 3 (from RefSeq NM_028886.2) ENSMUST00000070189.1 ENSMUST00000070189.2 ENSMUST00000070189.3 ENSMUST00000070189.4 ENSMUST00000070189.5 ENSMUST00000070189.6 ENSMUST00000070189.7 ENSMUST00000070189.8 ENSMUST00000070189.9 LRGUK_MOUSE NM_028886 Q9D5S7 uc009bgv.1 uc009bgv.2 Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development (PubMed:25781171). Not essential for primary cilium biogenesis (PubMed:28003339). Interacts (via guanylate kinase-like domain) with RIMBP3 (via coiled-coil region) (PubMed:28003339). Interacts (via guanylate kinase- like domain) with HOOK2 (PubMed:25781171, PubMed:28003339). Interacts (via LRRCT domain) with KLC3. Interacts with HOOK1 and HOOK3 (PubMed:28003339). Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, cilium basal body Note=Localizes to the acrosome and acroplaxome in round spermatids. Localizes to the manchette during spermiogenesis. Also found in the basal body of elongating spermatids, and in primary cilia of somatic cells. Highly expressed in the testis (PubMed:25781171). During spermatid development is initially localized to a supra-nuclear region of round spermatids, and is particularly evident at the leading edge of the developing acrosome and acroplaxome. As maturation proceeded and nuclear elongation initiated, LRGUK moves distally to ultimately reside on the microtubules of the manchette. LRGUK is also evident in the sperm basal body and the sperm tail (PubMed:25781171). Detectable at low levels from birth, up-regulated at day 14 coincident with the appearance of pachytene spermatocytes, then maximal from day 18 coincident with the appearance of haploid germ cells (PubMed:25781171). Mutagenesis with N-ethyl-N-nitrosourea (ENU) lead to the discovery of the Kaos phenotype. The Kaos mutation results in the conversion of Arg-528 to a stop codon. Homozygous males are oligoasthenoteratospermic and sterile. nucleotide binding acrosomal vesicle manchette guanylate kinase activity protein binding ATP binding cytoplasm cytosol cytoskeleton spermatogenesis kinase activity phosphorylation transferase activity cell differentiation cytoplasmic vesicle axoneme assembly cell projection GMP metabolic process GDP metabolic process uc009bgv.1 uc009bgv.2 
ENSMUST00000070200.15 Pla2g4a ENSMUST00000070200.15 phospholipase A2, group IVA (cytosolic, calcium-dependent), transcript variant 1 (from RefSeq NM_008869.4) ENSMUST00000070200.1 ENSMUST00000070200.10 ENSMUST00000070200.11 ENSMUST00000070200.12 ENSMUST00000070200.13 ENSMUST00000070200.14 ENSMUST00000070200.2 ENSMUST00000070200.3 ENSMUST00000070200.4 ENSMUST00000070200.5 ENSMUST00000070200.6 ENSMUST00000070200.7 ENSMUST00000070200.8 ENSMUST00000070200.9 NM_008869 Pla2g4a Q3UMQ1 Q3UMQ1_MOUSE uc007cxt.1 uc007cxt.2 uc007cxt.3 uc007cxt.4 The protein encoded by this gene is a member of the phospholipase A2 group IV family. This enzyme hydrolyzes membrane phospholipids, thereby releasing the polyunsaturated fatty acid, arachidonic acid. Arachidonic acid is further metabolized into eicosanoids such as leukotrienes, thromboxanes and prostaglandins, that play important roles in regulating diverse biological processes such as inflammatory responses, membrane and actin dynamics, and tumorigenesis. A rise in intracellular calcium levels results in binding of calcium to the C2 domain of this protein, and triggers the translocation from the cytosol to intracellular membranes, including the Golgi apparatus. Disruption of this gene in mice led to decreased levels of eicosonaoids and platelet-activating factor, decreased allergic symptoms, and impaired reproductive ability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]. Reaction=1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3- phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41075, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:60657, ChEBI:CHEBI:74344; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41076; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3- phospho-(1'-sn-glycerol) + H(+); Xref=Rhea:RHEA:41123, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72828, ChEBI:CHEBI:75163; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41124; Evidence=; Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3- phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O- hexadecyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41271, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:77695, ChEBI:CHEBI:77696; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41272; Evidence=; Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero- 3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn- glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41071, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74344, ChEBI:CHEBI:77694; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41072; Evidence=; Reaction=1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3- phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O- hexadecyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41067, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:55430, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41068; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn- glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40812; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- octadecanoyl-sn-glycero-3-phosphate + H(+); Xref=Rhea:RHEA:40451, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:74565, ChEBI:CHEBI:77091; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40452; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- octadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40519, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73858, ChEBI:CHEBI:74965; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40520; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)- glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:41099, ChEBI:CHEBI:17754, ChEBI:CHEBI:73858, ChEBI:CHEBI:74965, ChEBI:CHEBI:75612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41100; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3- phosphocholine + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1- octadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41307, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32387, ChEBI:CHEBI:73858, ChEBI:CHEBI:78022; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41308; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3- phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:41087, ChEBI:CHEBI:17754, ChEBI:CHEBI:73858, ChEBI:CHEBI:75610, ChEBI:CHEBI:78022; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41088; Evidence=; Reaction=2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O = H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:53692, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:137585, ChEBI:CHEBI:606564; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53693; Evidence=; Reaction=2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O = H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:53704, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:137581, ChEBI:CHEBI:143890, ChEBI:CHEBI:606564; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53705; Evidence=; Reaction=2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero- 3-phosphocholine + H2O = (11R)-hydroxy-(5Z,8Z,12E,14Z)- eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:53688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:78836, ChEBI:CHEBI:137582; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53689; Evidence=; Reaction=2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero- 3-phosphocholine + H2O = (15R)-hydroxy-(5Z,8Z,11Z,13E)- eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:53696, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:78837, ChEBI:CHEBI:137583; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53697; Evidence=; Reaction=2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero- 3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)- eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:53700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:57409, ChEBI:CHEBI:137584; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53701; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15178; Evidence=; Lipid metabolism; arachidonate metabolism. Lipid metabolism; leukotriene B4 biosynthesis. Lipid metabolism; prostaglandin biosynthesis. Membrane lipid metabolism; glycerophospholipid metabolism. Interacts with KAT5. Cytoplasm Nucleus envelope The N-terminal C2 domain associates with lipid membranes upon calcium binding. phospholipase activity phospholipase A2 activity calcium ion binding calcium-dependent phospholipid binding cytoplasm lipid particle cytosol lipid metabolic process phospholipid catabolic process lipid catabolic process hydrolase activity metal ion binding uc007cxt.1 uc007cxt.2 uc007cxt.3 uc007cxt.4 
ENSMUST00000070215.8 Npm3 ENSMUST00000070215.8 nucleoplasmin 3 (from RefSeq NM_008723.2) ENSMUST00000070215.1 ENSMUST00000070215.2 ENSMUST00000070215.3 ENSMUST00000070215.4 ENSMUST00000070215.5 ENSMUST00000070215.6 ENSMUST00000070215.7 NM_008723 NPM3_MOUSE Q3UJ58 Q9CPP0 uc008hrk.1 uc008hrk.2 uc008hrk.3 Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function and the RNA- binding activity of nucleolar phosphoprotein B23/NPM. Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM. Interacts with NPM (via N-terminus). Forms a pentamer with NPM at a ratio 4:1 (NPM3/NPM). Two pentamers form a decamer. Nucleus Nucleus, nucleolus Note=Mainly found in the granular component of the nucleolus. Predominantly expressed in testis. Phosphorylated. Belongs to the nucleoplasmin family. chromatin binding protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol chromatin remodeling rRNA processing rRNA transcription actin cytoskeleton histone binding uc008hrk.1 uc008hrk.2 uc008hrk.3 
ENSMUST00000070216.9 Spata31 ENSMUST00000070216.9 spermatogenesis associated 31 (from RefSeq NM_030047.2) Aep1 E9QAF0 ENSMUST00000070216.1 ENSMUST00000070216.2 ENSMUST00000070216.3 ENSMUST00000070216.4 ENSMUST00000070216.5 ENSMUST00000070216.6 ENSMUST00000070216.7 ENSMUST00000070216.8 NM_030047 Q5MAT5 SPT31_MOUSE Vad1.3 uc007qza.1 uc007qza.2 uc007qza.3 uc007qza.4 May play a role in spermatogenesis. Interacts with ACTB and STX1A and/or STX1B. Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle, acrosome lumen Note=Localizes to the inner and outer membranes as well as to the matrix of the acrosome. Belongs to the SPATA31 family. acrosomal vesicle acrosomal membrane actin binding spermatogenesis biological_process membrane integral component of membrane cell differentiation cytoplasmic vesicle acrosomal lumen uc007qza.1 uc007qza.2 uc007qza.3 uc007qza.4 
ENSMUST00000070219.9 Pard6g ENSMUST00000070219.9 par-6 family cell polarity regulator gamma (from RefSeq NM_053117.3) ENSMUST00000070219.1 ENSMUST00000070219.2 ENSMUST00000070219.3 ENSMUST00000070219.4 ENSMUST00000070219.5 ENSMUST00000070219.6 ENSMUST00000070219.7 ENSMUST00000070219.8 NM_053117 PAR6G_MOUSE Par6g Q9JK84 uc008fsj.1 uc008fsj.2 uc008fsj.3 uc008fsj.4 Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Interacts with PARD3 (Probable). Interacts with GTP-bound forms of CDC42, RHOQ/TC10 and RAC1 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ (By similarity). Cytoplasm. Cell membrane Cell junction, tight junction The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases. Belongs to the PAR6 family. protein kinase C binding nucleus cytoplasm plasma membrane bicellular tight junction cell cortex cell cycle centrosome cycle establishment or maintenance of cell polarity membrane apical plasma membrane Rho GTPase binding cell junction macromolecular complex cell division regulation of cellular localization uc008fsj.1 uc008fsj.2 uc008fsj.3 uc008fsj.4 
ENSMUST00000070223.6 Khdc1c ENSMUST00000070223.6 KH domain containing 1C (from RefSeq NM_001033904.1) ENSMUST00000070223.1 ENSMUST00000070223.2 ENSMUST00000070223.3 ENSMUST00000070223.4 ENSMUST00000070223.5 KHD1C_MOUSE NM_001033904 Q4KL78 uc007alo.1 uc007alo.2 uc007alo.3 Belongs to the KHDC1 family. RNA binding cytoplasm activation of cysteine-type endopeptidase activity involved in apoptotic process uc007alo.1 uc007alo.2 uc007alo.3 
ENSMUST00000070256.9 Kcnq3 ENSMUST00000070256.9 potassium voltage-gated channel, subfamily Q, member 3 (from RefSeq NM_152923.3) E9QJY5 ENSMUST00000070256.1 ENSMUST00000070256.2 ENSMUST00000070256.3 ENSMUST00000070256.4 ENSMUST00000070256.5 ENSMUST00000070256.6 ENSMUST00000070256.7 ENSMUST00000070256.8 KCNQ3_MOUSE Kcnq3 NM_152923 Q8K3F6 uc007wab.1 uc007wab.2 uc007wab.3 uc007wab.4 Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation. Heterotetramer with KCNQ2; form the heterotetrameric M potassium channel. Interacts with calmodulin; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel. Heteromultimer with KCNQ5. May associate with KCNE2. Interacts with IQCJ-SCHIP1 (PubMed:27979964). Cell membrane ; Multi-pass membrane protein The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. KCNQ2/KCNQ3 are ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation. Degradation induced by NEDD4L is inhibited by USP36. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity calmodulin binding plasma membrane integral component of plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex cell surface membrane integral component of membrane protein kinase binding dendrite ubiquitin protein ligase binding node of Ranvier ion transmembrane transport regulation of ion transmembrane transport somatodendritic compartment neuron projection neuronal cell body axon initial segment ion channel binding membrane raft transmembrane transport membrane hyperpolarization cellular response to ammonium ion potassium ion transmembrane transport uc007wab.1 uc007wab.2 uc007wab.3 uc007wab.4 
ENSMUST00000070257.14 Ascc2 ENSMUST00000070257.14 activating signal cointegrator 1 complex subunit 2, transcript variant 1 (from RefSeq NM_029291.2) ASCC2_MOUSE Asc1p100 ENSMUST00000070257.1 ENSMUST00000070257.10 ENSMUST00000070257.11 ENSMUST00000070257.12 ENSMUST00000070257.13 ENSMUST00000070257.2 ENSMUST00000070257.3 ENSMUST00000070257.4 ENSMUST00000070257.5 ENSMUST00000070257.6 ENSMUST00000070257.7 ENSMUST00000070257.8 ENSMUST00000070257.9 NM_029291 Q5NCK1 Q8BKM9 Q8BX60 Q8R1B9 Q91WR3 uc007hva.1 uc007hva.2 uc007hva.3 uc007hva.4 uc007hva.5 Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes. Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa- B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes. Identified in the ASCC complex that contains ASCC1, ASCC2 and ASCC3. Interacts directly with ASCC3. The ASCC complex interacts with ALKBH3. Interacts (via CUE domain) with 'Lys-63'-linked polyubiquitin chains, but not with 'Lys-48'-linked polyubiquitin chains. Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3. Component of the RQT (ribosome quality control trigger) complex, that contains ASCC2, ASCC3 and TRIP4. Interacts with CSRP1. Interacts with PRPF8, a component of the spliceosome. Interacts with ZCCHC4. Nucleus Nucleus speckle Note=Colocalizes with the spliceosomal components PRPF8 and SNRNP200/BRR2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Colocalizes with RNF113A and 'Lys-63'-linked polyubiquitinated proteins, ALKBH3 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q91WR3-1; Sequence=Displayed; Name=2; Synonyms=100S; IsoId=Q91WR3-2; Sequence=VSP_011012; Name=3; IsoId=Q91WR3-3; Sequence=VSP_011013; The CUE domain specifically binds RPS20/uS10 ubiquitinated via 'Lys-63'-linked ubiquitin chains by ZNF598. [Isoform 3]: Incomplete sequence. Belongs to the ASCC2 family. nucleus DNA repair regulation of transcription, DNA-templated cellular response to DNA damage stimulus nuclear speck ubiquitin binding activating signal cointegrator 1 complex uc007hva.1 uc007hva.2 uc007hva.3 uc007hva.4 uc007hva.5 
ENSMUST00000070284.4 Prr9 ENSMUST00000070284.4 proline rich 9 (from RefSeq NM_175424.3) ENSMUST00000070284.1 ENSMUST00000070284.2 ENSMUST00000070284.3 NM_175424 PRR9_MOUSE Q8BV84 uc008qdm.1 uc008qdm.2 uc008qdm.1 uc008qdm.2 
ENSMUST00000070316.12 Gpr173 ENSMUST00000070316.12 G-protein coupled receptor 173, transcript variant 1 (from RefSeq NM_027543.5) A2AHI2 ENSMUST00000070316.1 ENSMUST00000070316.10 ENSMUST00000070316.11 ENSMUST00000070316.2 ENSMUST00000070316.3 ENSMUST00000070316.4 ENSMUST00000070316.5 ENSMUST00000070316.6 ENSMUST00000070316.7 ENSMUST00000070316.8 ENSMUST00000070316.9 GP173_MOUSE NM_027543 Q4VA66 Q6PI62 Sreb3 uc009uqh.1 uc009uqh.2 uc009uqh.3 uc009uqh.4 Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (PubMed:27268078). It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (PubMed:27268078). In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth (PubMed:30933929). Cell membrane ; Multi-pass membrane protein Expressed in the ovary, specifically in granulosa cells of follicles that have passed the primary stage and in oocytes (at protein level) (PubMed:30933929). Expressed in preadipocytes (PubMed:30251651). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity gonadotropin-releasing hormone receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane cellular response to gonadotropin-releasing hormone negative regulation of neuron migration uc009uqh.1 uc009uqh.2 uc009uqh.3 uc009uqh.4 
ENSMUST00000070323.12 Synpr ENSMUST00000070323.12 synaptoporin, transcript variant 1 (from RefSeq NM_028052.4) ENSMUST00000070323.1 ENSMUST00000070323.10 ENSMUST00000070323.11 ENSMUST00000070323.2 ENSMUST00000070323.3 ENSMUST00000070323.4 ENSMUST00000070323.5 ENSMUST00000070323.6 ENSMUST00000070323.7 ENSMUST00000070323.8 ENSMUST00000070323.9 NM_028052 Q8BGN8 Q8C5J4 Q9DB89 SYNPR_MOUSE uc007sfy.1 uc007sfy.2 uc007sfy.3 uc007sfy.4 Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Synapse, synaptosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGN8-1; Sequence=Displayed; Name=2; IsoId=Q8BGN8-2; Sequence=VSP_008550; Belongs to the synaptophysin/synaptobrevin family. synaptic vesicle membrane integral component of membrane syntaxin-1 binding cell junction integral component of synaptic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle neuron projection synapse uc007sfy.1 uc007sfy.2 uc007sfy.3 uc007sfy.4 
ENSMUST00000070326.14 Ttk ENSMUST00000070326.14 Ttk protein kinase, transcript variant 1 (from RefSeq NM_009445.3) ENSMUST00000070326.1 ENSMUST00000070326.10 ENSMUST00000070326.11 ENSMUST00000070326.12 ENSMUST00000070326.13 ENSMUST00000070326.2 ENSMUST00000070326.3 ENSMUST00000070326.4 ENSMUST00000070326.5 ENSMUST00000070326.6 ENSMUST00000070326.7 ENSMUST00000070326.8 ENSMUST00000070326.9 Esk NM_009445 P35761 TTK_MOUSE uc012gxl.1 uc012gxl.2 uc012gxl.3 Phosphorylates proteins on serine, threonine, and tyrosine (By similarity). Probably associated with cell proliferation (By similarity). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (By similarity). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Inhibited by the ATP-competitive kinase inhibitor, SP600125. Interacts with TPR; the interactions occurs in a microtubule- independent manner (By similarity). Interacts with MAD1L1 and MAD2L1 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P35761-1; Sequence=Displayed; Name=2; IsoId=P35761-2; Sequence=VSP_004875; Present in rapidly proliferating cell lines; high levels in testis, bone marrow, spleen and thymus. Low levels in brain, heart, lung and kidney. Autophosphorylated. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding kinetochore protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity ATP binding nucleus cytoplasm spindle protein phosphorylation chromosome segregation mitotic cell cycle checkpoint mitotic spindle assembly checkpoint membrane kinase activity phosphorylation female meiosis chromosome segregation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation meiotic spindle assembly checkpoint protein localization to kinetochore protein localization to chromosome protein homodimerization activity kinetochore binding protein autophosphorylation chromosome separation protein localization to meiotic spindle midzone uc012gxl.1 uc012gxl.2 uc012gxl.3 
ENSMUST00000070330.14 Dnm3 ENSMUST00000070330.14 dynamin 3, transcript variant 2 (from RefSeq NM_172646.3) B2RUH0 DYN3_MOUSE ENSMUST00000070330.1 ENSMUST00000070330.10 ENSMUST00000070330.11 ENSMUST00000070330.12 ENSMUST00000070330.13 ENSMUST00000070330.2 ENSMUST00000070330.3 ENSMUST00000070330.4 ENSMUST00000070330.5 ENSMUST00000070330.6 ENSMUST00000070330.7 ENSMUST00000070330.8 ENSMUST00000070330.9 Kiaa0820 NM_172646 Q3UGY9 Q80TR2 Q8BWW6 Q8BZ98 uc007dgb.1 uc007dgb.2 uc007dgb.3 uc007dgb.4 Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5; Q8BZ98; Q7TQF7: Amph; NbExp=2; IntAct=EBI-6880033, EBI-775139; Cytoplasm Cytoplasm, cytoskeleton Note=Microtubule-associated. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZ98-1; Sequence=Displayed; Name=2; IsoId=Q8BZ98-2; Sequence=VSP_031548; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. nucleotide binding mitochondrial fission photoreceptor inner segment GTPase activity protein binding GTP binding cytoplasm mitochondrion Golgi apparatus cytoskeleton microtubule plasma membrane endocytosis synapse assembly microtubule binding postsynaptic density membrane synaptic vesicle budding from presynaptic endocytic zone membrane hydrolase activity axon cytoplasmic vesicle receptor internalization type 1 metabotropic glutamate receptor binding type 5 metabotropic glutamate receptor binding identical protein binding synaptic cleft dendritic spine dendritic spine head synapse postsynaptic membrane filopodium assembly perinuclear region of cytoplasm synaptic vesicle endocytosis regulation of synapse structure or activity nitric-oxide synthase binding positive regulation of filopodium assembly regulation of dendritic spine morphogenesis negative regulation of dendritic spine morphogenesis presynapse postsynaptic endocytic zone membrane postsynaptic neurotransmitter receptor internalization glutamatergic synapse positive regulation of synaptic vesicle recycling uc007dgb.1 uc007dgb.2 uc007dgb.3 uc007dgb.4 
ENSMUST00000070334.10 G6pc3 ENSMUST00000070334.10 Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function. (from UniProt Q6NSQ9) AK002966 ENSMUST00000070334.1 ENSMUST00000070334.2 ENSMUST00000070334.3 ENSMUST00000070334.4 ENSMUST00000070334.5 ENSMUST00000070334.6 ENSMUST00000070334.7 ENSMUST00000070334.8 ENSMUST00000070334.9 G6PC3_MOUSE Q3TND0 Q6NSQ9 Q811R8 Ugrp uc057kmn.1 uc057kmn.2 Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function. Reaction=D-glucose 6-phosphate + H2O = D-glucose + phosphate; Xref=Rhea:RHEA:16689, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:61548; EC=3.1.3.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16690; Evidence=; Inhibited by vanadate. pH dependence: Optimum pH is 6.5. ; Temperature dependence: Optimum temperature is 37 degrees Celsius. ; Carbohydrate biosynthesis; gluconeogenesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Widely expressed. Highly expressed in heart and testis and to a lower extent in spleen, stomach, small intestine, skeletal muscle and uterus. Expressed in muscle, brain, thymus, lung, kidney, spleen and pancreas (at protein level). In the brain, expressed in astrocytes (at protein level) (PubMed:15661744). Mice display reduced glucose-6-phosphate hydrolytic activity in the brain. No phenotypic difference was noted at birth but 4 months old female mice display growth retardation. Mutant mice exhibit a decreased plasma cholesterol concentration and an increased plasma glucagon concentration but no difference in blood glucose concentration (PubMed:17023421). Mice display neutropenia and neutrophil dysfunctions. Belongs to the glucose-6-phosphatase family. glucose-6-phosphatase activity endoplasmic reticulum endoplasmic reticulum membrane gluconeogenesis phosphate-containing compound metabolic process glucose-6-phosphate transport membrane integral component of membrane dephosphorylation hydrolase activity glucose 6-phosphate metabolic process uc057kmn.1 uc057kmn.2 
ENSMUST00000070340.6 Purg ENSMUST00000070340.6 purine-rich element binding protein G, transcript variant 1 (from RefSeq NM_152821.2) ENSMUST00000070340.1 ENSMUST00000070340.2 ENSMUST00000070340.3 ENSMUST00000070340.4 ENSMUST00000070340.5 NM_152821 PURG_MOUSE Q14B11 Q8R4E6 Q8R4E7 uc033jew.1 uc033jew.2 uc033jew.3 Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PURG-A; IsoId=Q8R4E6-1; Sequence=Displayed; Name=2; Synonyms=PURG-A; IsoId=Q8R4E6-2; Sequence=VSP_021320; Isoform 1 is expressed in testis. Isoform 2 is expressed in blastocyst and kidney. Belongs to the PUR DNA-binding protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding nucleus biological_process purine-rich negative regulatory element binding sequence-specific DNA binding uc033jew.1 uc033jew.2 uc033jew.3 
ENSMUST00000070342.4 Sertm1 ENSMUST00000070342.4 serine rich and transmembrane domain containing 1 (from RefSeq NM_177854.4) ENSMUST00000070342.1 ENSMUST00000070342.2 ENSMUST00000070342.3 NM_177854 Q8CD78 SRTM1_MOUSE uc008pfx.1 uc008pfx.2 uc008pfx.3 uc008pfx.4 uc008pfx.5 Membrane ; Single-pass membrane protein molecular_function biological_process membrane integral component of membrane intracellular membrane-bounded organelle uc008pfx.1 uc008pfx.2 uc008pfx.3 uc008pfx.4 uc008pfx.5 
ENSMUST00000070345.5 Usp39 ENSMUST00000070345.5 ubiquitin specific peptidase 39, transcript variant 3 (from RefSeq NR_177101.1) ENSMUST00000070345.1 ENSMUST00000070345.2 ENSMUST00000070345.3 ENSMUST00000070345.4 NR_177101 Q3TI55 Q3TIX9 Q8BLI5 Q8BZZ5 Q9CQR1 UBP39_MOUSE Usp39 uc009cif.1 uc009cif.2 uc009cif.3 Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:35139388, PubMed:35440748, PubMed:36651806). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (By similarity). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2. Plays also an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair. Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (By similarity). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa- B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Nucleus USP39-deficient embryos display early embryonic lethality due to a failure in primitive streak formation and apico- basal polarity in epiblast cells (PubMed:35440748). In addition, USP39- deficient mice are more sensitive to LPS stimulation and bacterial infection (PubMed:36651806). Belongs to the peptidase C19 family. Lacks the conserved His and Cys residues that are essential for the activity of de-ubiquitinating enzymes. Lacks ubiquitin C- terminal hydrolase activity. spliceosomal complex assembly mRNA splicing, via spliceosome nucleus nucleoplasm spliceosomal complex mRNA processing cell cycle zinc ion binding RNA splicing protein deubiquitination thiol-dependent ubiquitinyl hydrolase activity U4/U6 x U5 tri-snRNP complex metal ion binding cell division uc009cif.1 uc009cif.2 uc009cif.3 
ENSMUST00000070353.4 Slc24a5 ENSMUST00000070353.4 solute carrier family 24, member 5 (from RefSeq NM_175034.4) ENSMUST00000070353.1 ENSMUST00000070353.2 ENSMUST00000070353.3 NCKX5_MOUSE NM_175034 Nckx5 Q6XE39 Q8C261 Q8CJF1 uc008mbv.1 uc008mbv.2 uc008mbv.3 Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes. Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29108; Evidence=; Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Melanosome Highly expressed in melanin-producing cells such as skin and eye compared to other tissues. Strongly overexpressed in melanoma cell lines. Expressed in dental tissues. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. Sequence=BAC24122.1; Type=Frameshift; Evidence=; Name=Protein Spotlight; Note=Skin-deep - Issue 74 of September 2006; URL="https://web.expasy.org/spotlight/back_issues/074"; calcium channel activity Golgi apparatus trans-Golgi network ion transport potassium ion transport sodium ion transport calcium ion transport cellular calcium ion homeostasis calcium, potassium:sodium antiporter activity symporter activity antiporter activity membrane integral component of membrane melanocyte differentiation ion transmembrane transport sodium ion transmembrane transport melanosome negative regulation of melanin biosynthetic process response to stimulus transmembrane transport calcium ion transmembrane transport potassium ion transmembrane transport anion transmembrane transport uc008mbv.1 uc008mbv.2 uc008mbv.3 
ENSMUST00000070359.3 Gm9996 ENSMUST00000070359.3 Gm9996 (from geneSymbol) AK029414 ENSMUST00000070359.1 ENSMUST00000070359.2 uc287qgu.1 uc287qgu.2 uc287qgu.1 uc287qgu.2 
ENSMUST00000070368.8 Siah2 ENSMUST00000070368.8 siah E3 ubiquitin protein ligase 2 (from RefSeq NM_009174.3) ENSMUST00000070368.1 ENSMUST00000070368.2 ENSMUST00000070368.3 ENSMUST00000070368.4 ENSMUST00000070368.5 ENSMUST00000070368.6 ENSMUST00000070368.7 NM_009174 Q3UEV2 Q3UEV2_MOUSE Siah2 uc008pia.1 uc008pia.2 uc008pia.3 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence= Protein modification; protein ubiquitination. The RING-type zinc finger domain is essential for ubiquitin ligase activity. The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. Belongs to the SINA (Seven in absentia) family. nucleus nucleoplasm early endosome cytosol ubiquitin-dependent protein catabolic process multicellular organism development zinc ion binding protein ubiquitination regulation of protein ubiquitination ubiquitin conjugating enzyme binding regulation of circadian rhythm neuron projection neuronal cell body negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process intracellular membrane-bounded organelle cellular protein catabolic process metal ion binding negative regulation of canonical Wnt signaling pathway negative regulation of extrinsic apoptotic signaling pathway uc008pia.1 uc008pia.2 uc008pia.3 
ENSMUST00000070375.8 Penk ENSMUST00000070375.8 preproenkephalin, transcript variant 2 (from RefSeq NM_001348209.1) ENSMUST00000070375.1 ENSMUST00000070375.2 ENSMUST00000070375.3 ENSMUST00000070375.4 ENSMUST00000070375.5 ENSMUST00000070375.6 ENSMUST00000070375.7 NM_001348209 P22005 PENK_MOUSE Penk1 Q68G73 uc008rwz.1 uc008rwz.2 uc008rwz.3 [Met-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. [Leu-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. [Met-enkephalin-Arg-Phe]: Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1 (PubMed:6933569, PubMed:35201898). Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release (PubMed:35201898). [PENK(114-133)]: Increases glutamate release in the striatum and decreases GABA concentration in the striatum. [PENK(238-259)]: Increases glutamate release in the striatum. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen Secreted Spermatogenic and somatic cells. Highest expression in late pachytene spermatocytes and postmeiotic round spermatids. Proenkephalin-A is cleaved by CTSL to generate Met-enkephalin. [Met-enkephalin]: Processed and degraded by ACE. [Leu-enkephalin]: Processed and degraded by ACE. [Met-enkephalin-Arg-Ser-Leu]: Probably cleaved by ACE. [Met-enkephalin-Arg-Phe]: Processed by ACE to generate Met- enkephalin in the nucleus accumbens of the brain. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. Belongs to the opioid neuropeptide precursor family. opioid peptide activity osteoblast differentiation behavioral fear response response to hypoxia startle response aggressive behavior extracellular region plasma membrane neuropeptide signaling pathway chemical synaptic transmission aging locomotory behavior response to radiation response to bacterium response to toxic substance glial cell proliferation sensory perception of pain axon dendrite opioid receptor binding symmetric synapse response to estradiol response to lipopolysaccharide synaptic vesicle lumen cellular response to oxidative stress response to nicotine locomotory exploration behavior neuronal cell body perikaryon response to morphine axon terminus response to ethanol response to calcium ion general adaptation syndrome, behavioral process cell body fiber cellular response to vitamin D cellular response to cAMP cellular response to transforming growth factor beta stimulus response to epinephrine cellular response to virus neuronal dense core vesicle lumen synaptic signaling via neuropeptide positive regulation of behavioral fear response uc008rwz.1 uc008rwz.2 uc008rwz.3 
ENSMUST00000070380.5 Prss2 ENSMUST00000070380.5 serine protease 2 (from RefSeq NM_009430.2) ENSMUST00000070380.1 ENSMUST00000070380.2 ENSMUST00000070380.3 ENSMUST00000070380.4 NM_009430 Prss2 Q792Y6 Q792Y6_MOUSE Ta trypsinogen uc009boz.1 uc009boz.2 uc009boz.3 uc009boz.4 Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4; Evidence=; serine-type endopeptidase activity extracellular space proteolysis response to nutrient peptidase activity serine-type peptidase activity response to organic substance hydrolase activity response to caffeine response to nicotine uc009boz.1 uc009boz.2 uc009boz.3 uc009boz.4 
ENSMUST00000070382.5 Gm16294 ENSMUST00000070382.5 predicted gene 16294 (from RefSeq NR_046185.1) ENSMUST00000070382.1 ENSMUST00000070382.2 ENSMUST00000070382.3 ENSMUST00000070382.4 NR_046185 uc029sou.1 uc029sou.2 uc029sou.1 uc029sou.2 
ENSMUST00000070395.9 Aarsd1 ENSMUST00000070395.9 alanyl-tRNA synthetase domain containing 1 (from RefSeq NM_144829.1) AASD1_MOUSE Alax ENSMUST00000070395.1 ENSMUST00000070395.2 ENSMUST00000070395.3 ENSMUST00000070395.4 ENSMUST00000070395.5 ENSMUST00000070395.6 ENSMUST00000070395.7 ENSMUST00000070395.8 NM_144829 Q3THG9 Q3UWH8 Q8BVJ6 Q99JS9 uc007los.1 uc007los.2 uc007los.3 uc007los.4 Functions in trans to edit the amino acid moiety from incorrectly charged Ser-tRNA(Ala). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Q3THG9; Q62406-1: Irak1; NbExp=4; IntAct=EBI-646572, EBI-488313; Cytoplasm Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. nucleotide binding aminoacyl-tRNA editing activity Ser-tRNA(Ala) hydrolase activity nucleic acid binding aminoacyl-tRNA ligase activity alanine-tRNA ligase activity protein binding ATP binding cytoplasm translation alanyl-tRNA aminoacylation regulation of translational fidelity tRNA aminoacylation metal ion binding uc007los.1 uc007los.2 uc007los.3 uc007los.4 
ENSMUST00000070449.6 Gpr50 ENSMUST00000070449.6 G-protein-coupled receptor 50, transcript variant 1 (from RefSeq NM_010340.2) ENSMUST00000070449.1 ENSMUST00000070449.2 ENSMUST00000070449.3 ENSMUST00000070449.4 ENSMUST00000070449.5 MTR1L_MOUSE NM_010340 O88495 Q3V1S8 uc009tke.1 uc009tke.2 uc009tke.3 This gene encodes a multipass membrane protein that is thought to act as a G protein-coupled receptor. Activity of this protein may be important in neurotransmitter and glucocorticoid signalling. Mutation of this gene causes a decreased ability to maintain a constant body temperature, resulting in torpor, as well as an increased metabolic rate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration (PubMed:17957037, PubMed:19699797). Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways (PubMed:25689717). Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalisation (PubMed:21858214). Plays also a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration (PubMed:29572483). Homodimer, and heterodimer with MTNR1A and MTNR1B. Interacts with KAT5 (PubMed:21858214). Interacts with RTN4 isoform A/NOGO-A (By similarity). Interacts with TGFBR1 (PubMed:29572483). O88495; Q8CHK4: Kat5; NbExp=3; IntAct=EBI-21227860, EBI-1169948; Cell membrane ulti-pass membrane protein. Postsynaptic density Strongly expressed in the brain with highly restricted pattern of expression, confined to a subset of the ependymal cells of the third ventricle and a population of cells in the dorsomedial hypothalamic nucleus. Expression in the brain is highly responsive to energy status being decreased by both fasting and high fat diet feeding (PubMed:19699797). Induced by TGFB (PubMed:29572483). GPR50-deletion mice exhibit significantly lower body weights in the weeks following weaning and by 10 weeks of age are significantly lighter than wild type mice. This is due in part by an increased metabolic rate (PubMed:17957037). In addition, glucocorticoid receptor signaling is significantly diminished in mice lacking GPR50 (PubMed:21858214). Belongs to the G-protein coupled receptor 1 family. It is uncertain whether Met-1 or Met-9 is the initiator. G-protein coupled receptor activity protein binding nucleoplasm plasma membrane signal transduction G-protein coupled receptor signaling pathway melatonin receptor activity membrane integral component of membrane identical protein binding uc009tke.1 uc009tke.2 uc009tke.3 
ENSMUST00000070458.11 Lrrc56 ENSMUST00000070458.11 leucine rich repeat containing 56, transcript variant 4 (from RefSeq NM_001357825.1) ENSMUST00000070458.1 ENSMUST00000070458.10 ENSMUST00000070458.2 ENSMUST00000070458.3 ENSMUST00000070458.4 ENSMUST00000070458.5 ENSMUST00000070458.6 ENSMUST00000070458.7 ENSMUST00000070458.8 ENSMUST00000070458.9 LRC56_MOUSE NM_001357825 Q571F2 Q8K375 uc009kjx.1 uc009kjx.2 uc009kjx.3 uc009kjx.4 Required for the assembly of dynein arms. Interacts with IFT88. Cell projection, cilium Belongs to the LRRC56 family. Sequence=BAD90162.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component cilium biological_process cell projection organization cell projection uc009kjx.1 uc009kjx.2 uc009kjx.3 uc009kjx.4 
ENSMUST00000070478.4 Sdc3 ENSMUST00000070478.4 syndecan 3, transcript variant 1 (from RefSeq NM_011520.4) ENSMUST00000070478.1 ENSMUST00000070478.2 ENSMUST00000070478.3 Kiaa0468 NM_011520 Q3UDD9 Q64519 Q6ZQA4 Q7TQD4 SDC3_MOUSE uc008uzr.1 uc008uzr.2 uc008uzr.3 Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism (By similarity). Interacts with TIAM1 (By similarity). Interacts with PTN (via heparan sulfate chains); this interaction mediates the neurite outgrowth-promoting signal from PTN to the cytoskeleton of growing neurites; this interaction mediates osteoblast recruitment (By similarity). Interacts with MDK; this interaction induces SDC3 clustering; this interaction induces neuronal cell adhesion and neurite outgrowth (PubMed:12084985). Cell membrane; Single-pass type I membrane protein. O-glycosylated within the Thr/Ser-rich region which could interact with lectin domains on other molecules. Belongs to the syndecan proteoglycan family. protein binding Golgi lumen plasma membrane cell adhesion cell surface membrane integral component of membrane cell migration regulation of cell migration axon macromolecular complex identical protein binding neuron projection microspike uc008uzr.1 uc008uzr.2 uc008uzr.3 
ENSMUST00000070481.8 Ppp1r3b ENSMUST00000070481.8 protein phosphatase 1, regulatory subunit 3B, transcript variant 1 (from RefSeq NM_177741.4) ENSMUST00000070481.1 ENSMUST00000070481.2 ENSMUST00000070481.3 ENSMUST00000070481.4 ENSMUST00000070481.5 ENSMUST00000070481.6 ENSMUST00000070481.7 NM_177741 PPR3B_MOUSE Ppp1r4 Q6PAJ7 Q8C767 uc009lkw.1 uc009lkw.2 uc009lkw.3 Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity (By similarity). Highly expressed in liver (at protein level). Expressed predominantly in liver. Expressed moderately in heart. Expressed weakly in prostate, stomach, thyroid, lung, kidney, spleen and skeletal muscle. Expressed in lung at 12.5 and 16.5 dpc and declines thereafter. Expressed in epithelial cells of the bronchus and smooth muscle of the pulmonary artery at 13.5 and 16.5 dpc. Up-regulated by TITF1. The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to PYGL. Sequence=AAH60261.1; Type=Erroneous initiation; Evidence=; protein phosphatase type 1 complex phosphoprotein phosphatase activity carbohydrate metabolic process glycogen metabolic process regulation of glycogen biosynthetic process regulation of glycogen catabolic process protein dephosphorylation protein phosphatase regulator activity enzyme binding glycogen granule intracellular membrane-bounded organelle regulation of phosphoprotein phosphatase activity [phosphorylase] phosphatase activity uc009lkw.1 uc009lkw.2 uc009lkw.3 
ENSMUST00000070514.4 Nat3 ENSMUST00000070514.4 N-acetyltransferase 3 (from RefSeq NM_008674.2) ENSMUST00000070514.1 ENSMUST00000070514.2 ENSMUST00000070514.3 NM_008674 Nat3 Q546K5 Q546K5_MOUSE uc009lvy.1 uc009lvy.2 Belongs to the arylamine N-acetyltransferase family. arylamine N-acetyltransferase activity N-acetyltransferase activity acetyltransferase activity transferase activity transferase activity, transferring acyl groups uc009lvy.1 uc009lvy.2 
ENSMUST00000070515.2 Ephx2 ENSMUST00000070515.2 epoxide hydrolase 2, cytoplasmic, transcript variant 1 (from RefSeq NM_007940.4) ENSMUST00000070515.1 Eph2 Ephx2 HYES_MOUSE NM_007940 P34914 Q8CGV0 uc007ujw.1 uc007ujw.2 uc007ujw.3 uc007ujw.4 Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:7840649, PubMed:21217101). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (By similarity). Bifunctional enzyme. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10- phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10- phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z- enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (By similarity). Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (By similarity). Reaction=an epoxide + H2O = an ethanediol; Xref=Rhea:RHEA:19037, ChEBI:CHEBI:15377, ChEBI:CHEBI:32955, ChEBI:CHEBI:140594; EC=3.3.2.10; Evidence=; Reaction=(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate; Xref=Rhea:RHEA:16537, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58796, ChEBI:CHEBI:58797; EC=3.1.3.76; Evidence=; Reaction=8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O = (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate; Xref=Rhea:RHEA:50896, ChEBI:CHEBI:15377, ChEBI:CHEBI:78100, ChEBI:CHEBI:132127; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50897; Evidence=; Reaction=10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O = (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:50900, ChEBI:CHEBI:15377, ChEBI:CHEBI:78084, ChEBI:CHEBI:78099; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50901; Evidence=; Reaction=(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)- dihydroxy-(5Z,11Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:53972, ChEBI:CHEBI:15377, ChEBI:CHEBI:131974, ChEBI:CHEBI:138002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53973; Evidence=; Reaction=(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:53980, ChEBI:CHEBI:15377, ChEBI:CHEBI:131969, ChEBI:CHEBI:138004; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53981; Evidence=; Reaction=(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:53984, ChEBI:CHEBI:15377, ChEBI:CHEBI:131969, ChEBI:CHEBI:138005; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53985; Evidence=; Reaction=(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)- dihydroxy-(5Z,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:53992, ChEBI:CHEBI:15377, ChEBI:CHEBI:131964, ChEBI:CHEBI:138003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53993; Evidence=; Reaction=(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)- dihydroxy-(5Z,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:53996, ChEBI:CHEBI:15377, ChEBI:CHEBI:131964, ChEBI:CHEBI:138006; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53997; Evidence=; Reaction=(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:54004, ChEBI:CHEBI:15377, ChEBI:CHEBI:131970, ChEBI:CHEBI:138005; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54005; Evidence=; Reaction=(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:54000, ChEBI:CHEBI:15377, ChEBI:CHEBI:131970, ChEBI:CHEBI:138004; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54001; Evidence=; Reaction=(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)- dihydroxy-(5Z,11Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:54016, ChEBI:CHEBI:15377, ChEBI:CHEBI:131974, ChEBI:CHEBI:138008; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54017; Evidence=; Reaction=12-phosphooxy-(9Z)-octadecenoate + H2O = 12-hydroxy-(9Z)- octadecenoate + phosphate; Xref=Rhea:RHEA:45272, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:85141, ChEBI:CHEBI:85150; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45273; Evidence=; Reaction=12-phosphooxy-(9E)-octadecenoate + H2O = 12-hydroxy-(9E)- octadecenoate + phosphate; Xref=Rhea:RHEA:45276, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:85137, ChEBI:CHEBI:85152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45277; Evidence=; Reaction=12-(phosphooxy)octadecanoate + H2O = 12-hydroxyoctadecanoate + phosphate; Xref=Rhea:RHEA:45280, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:84201, ChEBI:CHEBI:85134; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45281; Evidence=; Reaction=8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = 8,9-dihydroxy- (5Z,11Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:44048, ChEBI:CHEBI:15377, ChEBI:CHEBI:84025, ChEBI:CHEBI:84032; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44049; Evidence=; Reaction=11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = 11,12- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:44044, ChEBI:CHEBI:15377, ChEBI:CHEBI:76625, ChEBI:CHEBI:84031; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44045; Evidence=; Reaction=14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = 14,15- dihydroxy-(5Z,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:44040, ChEBI:CHEBI:15377, ChEBI:CHEBI:84024, ChEBI:CHEBI:84029; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44041; Evidence=; Reaction=9,10-epoxy-(12Z)-octadecenoate + H2O = 9,10-dihydroxy-(12Z)- octadecenoate; Xref=Rhea:RHEA:44032, ChEBI:CHEBI:15377, ChEBI:CHEBI:84023, ChEBI:CHEBI:84027; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44033; Evidence=; Reaction=1-tetradecanoyl-sn-glycerol 3-phosphate + H2O = 1- tetradecanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:53592, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:72683, ChEBI:CHEBI:75536; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53593; Evidence=; Reaction=1-octadecanoyl-sn-glycero-3-phosphate + H2O = 1-octadecanoyl- sn-glycerol + phosphate; Xref=Rhea:RHEA:53596, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:74565, ChEBI:CHEBI:75550; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53597; Evidence=; Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:53600, ChEBI:CHEBI:15377, ChEBI:CHEBI:34071, ChEBI:CHEBI:43474, ChEBI:CHEBI:74938; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53601; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl- sn-glycerol + phosphate; Xref=Rhea:RHEA:53604, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57518, ChEBI:CHEBI:75542; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53605; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z- octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:39835, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:74544, ChEBI:CHEBI:75757; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39836; Evidence=; Reaction=(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)- dihydroxy-(5Z,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:53976, ChEBI:CHEBI:15377, ChEBI:CHEBI:131965, ChEBI:CHEBI:138003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53977; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by 1-(1-acetylpiperidin-4-yl)-3-(4- (trifl uoromethoxy)phenyl)urea (TPAU), 1-cyclohexyl-3-dodecylurea (CDU), 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), 1-((3S, 5S, 7S)-adamantan-1-yl)-3-(5-(2-(2-ethoxyethoxy) ethoxy)pentyl)urea (AEPU), N-adamantyl-N[']-cyclohexyl urea (ACU), 4-(((1S, 4S)-4-(3-((3S, 5S, 7S)-adamantan-1-yl) ureido)cyclohexyl)oxy)benzoic acid (c-AUCB), 4- (((1R, 4R)-4-(3-((3S, 5S, 7S)-adamantan-1- yl)ureido)cyclohexyl)oxy)benzoic acid (t-AUCB), 4-(((1R, 4R)-4-(3- (4(trifluoromethoxy)phenyl)ureido)cyclohexyl)oxy)benzoic acid (t-TAUCB) and to a lesser extent by 8-(3-((3S, 5S, 7S)-adamantan-1-yl)ureido) octanoic acid (AUOA) (By similarity). Phosphatase activity is inhibited by dodecyl-phosphate, phospholipids such as phospho-lysophosphatidic acids and fatty acids such as palmitic acid and lauric acid (PubMed:21217101). Kinetic parameters: KM=4 uM for 14(R),15(S)-EET ; KM=5 uM for 14(S),15(R)-EET ; KM=3 uM for 11(R),12(R)-EET ; KM=4 uM for 11(S),12(R)-EET ; KM=41 uM for 8(R),9(S)-EET ; KM=5 uM for 8(S),9(R)-EET ; Vmax=9.03 umol/min/mg enzyme with 14(R),15(S)-EET as substrate ; Vmax=1.36 umol/min/mg enzyme with 14(S),15(R)-EET as substrate ; Vmax=0.82 umol/min/mg enzyme with 11(R),12(R)-EET as substrate ; Vmax=3.02 umol/min/mg enzyme with 11(S),12(R)-EET as substrate ; Vmax=0.83 umol/min/mg enzyme with 8(R),9(S)-EET as substrate ; Vmax=3.10 umol/min/mg enzyme with 8(S),9(R)-EET as substrate ; Homodimer. Cytoplasm roxisome. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Ephx2A; IsoId=P34914-1; Sequence=Displayed; Name=2; Synonyms=Ephx2B; IsoId=P34914-2; Sequence=VSP_013904; Detected in liver, intestine, ovary and kidney. Detected at low levels in heart and muscle. Up-regulated during the luteal phase of the stimulated estrus cycle and by compounds that cause peroxisome proliferation, such as clofibrate, tiadenol and fenofibrate. The N-terminal domain has phosphatase activity. The C-terminal domain has epoxide hydrolase activity. The N-terminus is blocked. The covalent modification of cysteine by 15-deoxy-Delta12,14- prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation (By similarity). In knockout mice, hepoxilin turnover to trioxilins is greatly abolished (PubMed:21217101). In livers, the activity toward HxA3 (8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)- eicosatrienoate) and HxB3 (10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)- eicosatrienoate) is greatly reduced compared with the WT mice (PubMed:21217101). Belongs to the AB hydrolase superfamily. Epoxide hydrolase family. magnesium ion binding prostaglandin production involved in inflammatory response catalytic activity epoxide hydrolase activity cytoplasm peroxisome cytosol lipid metabolic process inflammatory response metabolic process response to toxic substance positive regulation of gene expression toxic substance binding dephosphorylation hydrolase activity phosphatase activity sensory perception of pain aromatic compound catabolic process 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity lipid phosphatase activity cholesterol homeostasis protein homodimerization activity linoleic acid metabolic process positive regulation of blood pressure stilbene catabolic process phospholipid dephosphorylation metal ion binding regulation of cholesterol metabolic process epoxide metabolic process uc007ujw.1 uc007ujw.2 uc007ujw.3 uc007ujw.4 
ENSMUST00000070518.4 Nkg7 ENSMUST00000070518.4 natural killer cell group 7 sequence (from RefSeq NM_024253.4) ENSMUST00000070518.1 ENSMUST00000070518.2 ENSMUST00000070518.3 NM_024253 Nkg7 Q9CY55 Q9CY55_MOUSE uc009gmq.1 uc009gmq.2 uc009gmq.3 Membrane ; Multi- pass membrane protein Belongs to the PMP-22/EMP/MP20 family. membrane integral component of membrane uc009gmq.1 uc009gmq.2 uc009gmq.3 
ENSMUST00000070524.5 Tgoln1 ENSMUST00000070524.5 trans-golgi network protein (from RefSeq NM_009443.3) ENSMUST00000070524.1 ENSMUST00000070524.2 ENSMUST00000070524.3 ENSMUST00000070524.4 NM_009443 Q62313 TGON1_MOUSE Ttgn1 uc033isn.1 uc033isn.2 uc033isn.3 uc033isn.4 May be involved in regulating membrane traffic to and from trans-Golgi network. Cell membrane ; Single-pass type I membrane protein Golgi apparatus, trans-Golgi network membrane ; Single-pass type I membrane protein Note=Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes (By similarity). Widely expressed. Also found in strains BALB/c, C57BL/6 and DBA/2. endosome Golgi apparatus trans-Golgi network plasma membrane membrane integral component of membrane trans-Golgi network transport vesicle uc033isn.1 uc033isn.2 uc033isn.3 uc033isn.4 
ENSMUST00000070531.8 Uts2b ENSMUST00000070531.8 urotensin 2B (from RefSeq NM_198166.3) ENSMUST00000070531.1 ENSMUST00000070531.2 ENSMUST00000070531.3 ENSMUST00000070531.4 ENSMUST00000070531.5 ENSMUST00000070531.6 ENSMUST00000070531.7 NM_198166 Q765I1 UTS2B_MOUSE Urp Uts2d uc007yvm.1 uc007yvm.2 Potent vasoconstrictor. Secreted Belongs to the urotensin-2 family. G-protein coupled receptor binding hormone activity extracellular region signal transduction regulation of blood pressure regulation of blood vessel diameter uc007yvm.1 uc007yvm.2 
ENSMUST00000070532.8 Fabp3 ENSMUST00000070532.8 fatty acid binding protein 3, muscle and heart (from RefSeq NM_010174.2) ENSMUST00000070532.1 ENSMUST00000070532.2 ENSMUST00000070532.3 ENSMUST00000070532.4 ENSMUST00000070532.5 ENSMUST00000070532.6 ENSMUST00000070532.7 Fabp3 NM_010174 Q5EBJ0 Q5EBJ0_MOUSE uc008uzd.1 uc008uzd.2 uc008uzd.3 Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. long-chain fatty acid transporter activity fatty acid binding extracellular space cytoplasm cytosol fatty acid metabolic process cytoskeletal protein binding lipid binding long-chain fatty acid transport sarcoplasm response to insulin long-chain fatty acid binding response to drug icosatetraenoic acid binding oleic acid binding response to fatty acid uc008uzd.1 uc008uzd.2 uc008uzd.3 
ENSMUST00000070533.5 Xkr4 ENSMUST00000070533.5 X-linked Kx blood group related 4 (from RefSeq NM_001011874.1) ENSMUST00000070533.1 ENSMUST00000070533.2 ENSMUST00000070533.3 ENSMUST00000070533.4 NM_001011874 Q5GH67 XKR4_MOUSE Xkr4 Xrg4 uc007aeu.1 uc007aeu.2 [XK-related protein 4, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:25231987, PubMed:33725486). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:25231987, PubMed:33725486). [XK-related protein 4, processed form]: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence= Phospholipid scramblase activity is activated upon caspase cleavage to generate the XK-related protein 4, processed form (PubMed:25231987, PubMed:33725486). Does not act prior the onset of apoptosis (PubMed:25231987). [XK-related protein 4, processed form]: Homodimerizes upon caspase cleavage (PubMed:33725486). Phospholipid scramblase activity is activated following interaction with the processed C-terminus of XRCC4 (protein XRCC4, C-terminus) (PubMed:33725486). [XK-related protein 4, processed form]: Homodimer; homodimerization takes place upon caspase cleavage (PubMed:33725486). Interacts with the processed C-terminus of XRCC4 (protein XRCC4, C- terminus); interaction promotes the phospholipid scramblase activity (PubMed:33725486). Cell membrane ; Multi-pass membrane protein Highly expressed in expressed in the brain; weakly expressed in the spleen, thymus, uterus, blood vessels and fetus. [XK-related protein 4, processed form]: Undergoes proteolytic processing by caspase-3 (CASP3), caspase-6 (CASP6) and caspase-7 (CASP7) to generate the XK-related protein 4, processed form, leading to its activation. Belongs to the XK family. molecular_function plasma membrane membrane integral component of membrane engulfment of apoptotic cell phosphatidylserine exposure on apoptotic cell surface apoptotic process involved in development uc007aeu.1 uc007aeu.2 
ENSMUST00000070538.12 Rab12 ENSMUST00000070538.12 RAB12, member RAS oncogene family (from RefSeq NM_024448.3) A2CG35 A2CG35_MOUSE ENSMUST00000070538.1 ENSMUST00000070538.10 ENSMUST00000070538.11 ENSMUST00000070538.2 ENSMUST00000070538.3 ENSMUST00000070538.4 ENSMUST00000070538.5 ENSMUST00000070538.6 ENSMUST00000070538.7 ENSMUST00000070538.8 ENSMUST00000070538.9 NM_024448 Rab12 uc289mlp.1 uc289mlp.2 Membrane ; Lipid- anchor ; Cytoplasmic side Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding Rab protein signal transduction uc289mlp.1 uc289mlp.2 
ENSMUST00000070552.14 Osbp2 ENSMUST00000070552.14 oxysterol binding protein 2, transcript variant 1 (from RefSeq NM_152818.3) ENSMUST00000070552.1 ENSMUST00000070552.10 ENSMUST00000070552.11 ENSMUST00000070552.12 ENSMUST00000070552.13 ENSMUST00000070552.2 ENSMUST00000070552.3 ENSMUST00000070552.4 ENSMUST00000070552.5 ENSMUST00000070552.6 ENSMUST00000070552.7 ENSMUST00000070552.8 ENSMUST00000070552.9 NM_152818 OSBP2_MOUSE Q5QNQ6 Q8CF21 uc007htq.1 uc007htq.2 The protein encoded by this gene belongs to the oxysterol-binding protein-related family of proteins, which are defined by a C-terminal sterol domain with a highly conserved EQVSHHPP motif. Oxysterols are oxygenated derivatives of cholesterol that are involved in mechanisms that include apoptosis, cholesterol homeostasis, lipid trafficking and cell differentiation. This protein is selectively expressed at high levels in the brain and testis. Within the testis, the mRNA is localized to postmeiotic germ cells, including spermatids and spermatozoa, but is not detectable in somatic cells. Mice homozygous mutant for a targeted deletion in this gene do not exhibit overt developmental phenotypes but are male sterile. Females display normal fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Sequence Note: The RefSeq transcript and protein were derived from partial transcripts because no single transcript was available for the full length of the gene. The full-length structure is inferred from partial transcripts, RNA-seq data and orthologous alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.131757.1, SRR1660817.3301.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Binds 7-ketocholesterol. Membrane ; Peripheral membrane protein Belongs to the OSBP family. cytosol lipid transport spermatid development lipid binding cholesterol binding membrane sterol binding intracellular membrane-bounded organelle apical dendrite uc007htq.1 uc007htq.2 
ENSMUST00000070565.15 Mok ENSMUST00000070565.15 MOK protein kinase, transcript variant 21 (from RefSeq NR_184527.1) ENSMUST00000070565.1 ENSMUST00000070565.10 ENSMUST00000070565.11 ENSMUST00000070565.12 ENSMUST00000070565.13 ENSMUST00000070565.14 ENSMUST00000070565.2 ENSMUST00000070565.3 ENSMUST00000070565.4 ENSMUST00000070565.5 ENSMUST00000070565.6 ENSMUST00000070565.7 ENSMUST00000070565.8 ENSMUST00000070565.9 MOK_MOUSE NR_184527 Q8CFU4 Q9WVS4 Rage Stk30 uc007pbv.1 uc007pbv.2 Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (PubMed:10421840). Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner (PubMed:25243405). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Phosphorylation appears to increase the enzymatic activity. Cytoplasm Cell projection, cilium Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WVS4-1; Sequence=Displayed; Name=2; IsoId=Q9WVS4-2; Sequence=VSP_009147, VSP_009148, VSP_009149, VSP_009150; Highly expressed in testis, and less in kidney, brain and lung. Autophosphorylated. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus cytoplasm cilium protein phosphorylation regulation of gene expression kinase activity phosphorylation transferase activity intracellular signal transduction cell projection metal ion binding regulation of cell cycle ciliary base uc007pbv.1 uc007pbv.2 
ENSMUST00000070577.7 1700030J22Rik ENSMUST00000070577.7 RIKEN cDNA 1700030J22 gene, transcript variant 1 (from RefSeq NM_027103.3) CP046_MOUSE ENSMUST00000070577.1 ENSMUST00000070577.2 ENSMUST00000070577.3 ENSMUST00000070577.4 ENSMUST00000070577.5 ENSMUST00000070577.6 NM_027103 Q810Q8 Q8BHB7 Q9D9R4 uc009noq.1 uc009noq.2 uc009noq.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BHB7-1; Sequence=Displayed; Name=2; IsoId=Q8BHB7-2; Sequence=VSP_023436, VSP_023437; molecular_function nucleus nucleoplasm cytosol biological_process uc009noq.1 uc009noq.2 uc009noq.3 
ENSMUST00000070587.5 5730596B20Rik ENSMUST00000070587.5 RIKEN cDNA 5730596B20 gene (from RefSeq NR_163848.1) ENSMUST00000070587.1 ENSMUST00000070587.2 ENSMUST00000070587.3 ENSMUST00000070587.4 NR_163848 uc291emf.1 uc291emf.2 uc291emf.3 uc291emf.1 uc291emf.2 uc291emf.3 
ENSMUST00000070597.13 Retsat ENSMUST00000070597.13 retinol saturase (all trans retinol 13,14 reductase) (from RefSeq NM_026159.5) ENSMUST00000070597.1 ENSMUST00000070597.10 ENSMUST00000070597.11 ENSMUST00000070597.12 ENSMUST00000070597.2 ENSMUST00000070597.3 ENSMUST00000070597.4 ENSMUST00000070597.5 ENSMUST00000070597.6 ENSMUST00000070597.7 ENSMUST00000070597.8 ENSMUST00000070597.9 NM_026159 Ppsig Q149J8 Q3UNN9 Q64FW2 Q78JX8 Q8VHE7 Q9CW85 RETST_MOUSE uc009cix.1 uc009cix.2 uc009cix.3 Catalyzes the saturation of all-trans-retinol to all-trans- 13,14-dihydroretinol (PubMed:15358783, PubMed:17253779, PubMed:19139408). Does not exhibit any activity toward all-trans- retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers (PubMed:15358783). May play a role in the metabolism of vitamin A (PubMed:15358783, PubMed:17253779). Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP (PubMed:28855500). Required for adipocyte differentiation in a 3T3-L1 cell culture model (PubMed:19139408). This effect seems not to mimic the in vivo situation in which animals show increased adiposity in the absence of RETSAT (PubMed:19940255). Reaction=A + all-trans-13,14-dihydroretinol = AH2 + all-trans-retinol; Xref=Rhea:RHEA:19193, ChEBI:CHEBI:13193, ChEBI:CHEBI:17336, ChEBI:CHEBI:17499, ChEBI:CHEBI:52075; EC=1.3.99.23; Evidence= Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence=; Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Endoplasmic reticulum membrane ; Peripheral membrane protein Predominantly expressed in the liver (at protein level) (PubMed:19940255). Also expressed at high levels in kidney, intestine, and white fat and brown fat (PubMed:15358783, PubMed:18289917, PubMed:19139408, PubMed:28855500). Weakly expressed in heart, skeletal muscle and testis and barely detected in the lung, brain and spleen (PubMed:15358783, PubMed:18289917, PubMed:28855500). Up-regulated in the liver of diet-induced obese mice, compared to lean animals (PubMed:28855500). Down-regulated in adipose tissue of obese mice; this decrease could be due to the impact of inflammatory cells on adipocytes (PubMed:19139408). Up-regulated during adipocyte differentiation in a 3T3-L1 cell culture model (at protein level). Up-regulated during starvation (PubMed:18289917). Up- regulated by PPARG (PubMed:19139408). Knockout mice fed either low-fat or high-fat (HFD) diets gain weight at a similar rate as their wild-type littermates and show normal insulin resistance and glucose tolerance. However, they exhibit increased adiposity and increased expression of key adipogenic markers, including PPAR-gamma and its target adipocyte P2 (aP2/FABP4), while maintained on an HFD. Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. Sequence=BAB22406.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nuclear outer membrane endoplasmic reticulum endoplasmic reticulum membrane membrane oxidoreductase activity nuclear membrane retinol metabolic process all-trans-retinol 13,14-reductase activity oxidation-reduction process uc009cix.1 uc009cix.2 uc009cix.3 
ENSMUST00000070607.9 Haus6 ENSMUST00000070607.9 HAUS augmin-like complex, subunit 6 (from RefSeq NM_173400.3) 6230416J20Rik ENSMUST00000070607.1 ENSMUST00000070607.2 ENSMUST00000070607.3 ENSMUST00000070607.4 ENSMUST00000070607.5 ENSMUST00000070607.6 ENSMUST00000070607.7 ENSMUST00000070607.8 Haus6 NM_173400 Q6NV99 Q6NV99_MOUSE uc008tlx.1 uc008tlx.2 uc008tlx.3 uc008tlx.4 molecular_function centrosome microtubule organizing center cytosol centrosome cycle nuclear speck spindle assembly HAUS complex uc008tlx.1 uc008tlx.2 uc008tlx.3 uc008tlx.4 
ENSMUST00000070617.8 Scn11a ENSMUST00000070617.8 sodium channel, voltage-gated, type XI, alpha (from RefSeq NM_011887.3) E9QM88 ENSMUST00000070617.1 ENSMUST00000070617.2 ENSMUST00000070617.3 ENSMUST00000070617.4 ENSMUST00000070617.5 ENSMUST00000070617.6 ENSMUST00000070617.7 NM_011887 Nan Nat Q9JMD4 Q9R053 SCNBA_MOUSE Scn11a Sns2 uc009sbk.1 uc009sbk.2 uc009sbk.3 Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient (PubMed:24036948). Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system (PubMed:24036948). Also involved in rapid BDNF- evoked neuronal depolarization (By similarity). Reaction=Na(+)(in) = Na(+)(out); Xref=Rhea:RHEA:34963, ChEBI:CHEBI:29101; Evidence=; The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B and SCN3B. Cell membrane ; Multi-pass membrane protein Expressed in the dorsal root ganglia (C-fiber neurons), spinal cord, trigeminal ganglia, testis, ovary, uterus and small intestine. Expressed in embryo at 15 dpc onwards. The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily. voltage-gated sodium channel complex ion channel activity voltage-gated ion channel activity voltage-gated sodium channel activity sodium channel activity protein binding plasma membrane ion transport sodium ion transport membrane integral component of membrane neuronal action potential axon regulation of ion transmembrane transport sodium ion transmembrane transport C-fiber regulation of sensory perception of pain transmembrane transport membrane depolarization during action potential glutamatergic synapse integral component of presynaptic membrane uc009sbk.1 uc009sbk.2 uc009sbk.3 
ENSMUST00000070630.8 Cd248 ENSMUST00000070630.8 CD248 antigen, endosialin (from RefSeq NM_054042.2) CD248_MOUSE ENSMUST00000070630.1 ENSMUST00000070630.2 ENSMUST00000070630.3 ENSMUST00000070630.4 ENSMUST00000070630.5 ENSMUST00000070630.6 ENSMUST00000070630.7 NM_054042 Q3UMV6 Q91V98 Q91ZV1 Tem1 uc008gcb.1 uc008gcb.2 uc008gcb.3 uc008gcb.4 uc008gcb.5 May play a role in angiogenesis or vascular function. Membrane ; Single-pass type I membrane protein Expressed in cell lines derived from endothelial cells, embryonic fibroblasts and preadipocytes. Detected at 19 dpc in embryo. O-glycosylated by sialylated oligosaccharides. May be N-glycosylated. calcium ion binding cytoplasm plasma membrane positive regulation of cell proliferation external side of plasma membrane membrane integral component of membrane cell migration carbohydrate binding lymph node development extracellular matrix binding anatomical structure regression extracellular matrix protein binding positive regulation of endothelial cell apoptotic process uc008gcb.1 uc008gcb.2 uc008gcb.3 uc008gcb.4 uc008gcb.5 
ENSMUST00000070631.15 Ddx60 ENSMUST00000070631.15 DExD/H box helicase 60 (from RefSeq NM_001293783.2) Ddx60 ENSMUST00000070631.1 ENSMUST00000070631.10 ENSMUST00000070631.11 ENSMUST00000070631.12 ENSMUST00000070631.13 ENSMUST00000070631.14 ENSMUST00000070631.2 ENSMUST00000070631.3 ENSMUST00000070631.4 ENSMUST00000070631.5 ENSMUST00000070631.6 ENSMUST00000070631.7 ENSMUST00000070631.8 ENSMUST00000070631.9 G3X9F7 G3X9F7_MOUSE NM_001293783 uc009lum.1 uc009lum.2 uc009lum.3 uc009lum.4 nucleic acid binding double-stranded DNA binding RNA binding double-stranded RNA binding single-stranded RNA binding protein binding ATP binding cytoplasm cytosol response to virus intermediate filament cytoskeleton defense response to virus positive regulation of MDA-5 signaling pathway positive regulation of RIG-I signaling pathway uc009lum.1 uc009lum.2 uc009lum.3 uc009lum.4 
ENSMUST00000070639.8 Pira12 ENSMUST00000070639.8 paired-Ig-like receptor A12, transcript variant 2 (from RefSeq NM_001384210.1) E9Q1Z6 E9Q1Z6_MOUSE ENSMUST00000070639.1 ENSMUST00000070639.2 ENSMUST00000070639.3 ENSMUST00000070639.4 ENSMUST00000070639.5 ENSMUST00000070639.6 ENSMUST00000070639.7 Gm14548 NM_001384210 Pira12 uc012ewi.1 uc012ewi.2 uc012ewi.3 uc012ewi.4 uc012ewi.5 uc012ewi.6 molecular_function cellular_component biological_process uc012ewi.1 uc012ewi.2 uc012ewi.3 uc012ewi.4 uc012ewi.5 uc012ewi.6 
ENSMUST00000070642.4 Cebpb ENSMUST00000070642.4 CCAAT/enhancer binding protein beta, transcript variant 1 (from RefSeq NM_009883.4) Cebpb ENSMUST00000070642.1 ENSMUST00000070642.2 ENSMUST00000070642.3 NM_009883 Q3UPN9 Q3UPN9_MOUSE uc008oaf.1 uc008oaf.2 uc008oaf.3 uc008oaf.4 Nucleus Belongs to the bZIP family. C/EBP subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding liver development DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated memory transcription factor binding nuclear matrix response to endoplasmic reticulum stress glucocorticoid receptor binding CHOP-C/EBP complex protein homodimerization activity sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity positive regulation of biomineral tissue development cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to organic cyclic compound hepatocyte proliferation regulation of odontoblast differentiation positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of sodium-dependent phosphate transport uc008oaf.1 uc008oaf.2 uc008oaf.3 uc008oaf.4 
ENSMUST00000070649.2 Ccdc70 ENSMUST00000070649.2 coiled-coil domain containing 70, transcript variant 2 (from RefSeq NM_001357224.1) CCD70_MOUSE Ccdc70 ENSMUST00000070649.1 NM_001357224 Q9D9B0 Q9D9H6 uc009lci.1 uc009lci.2 uc009lci.3 molecular_function extracellular region plasma membrane biological_process uc009lci.1 uc009lci.2 uc009lci.3 
ENSMUST00000070658.16 Mgrn1 ENSMUST00000070658.16 mahogunin, ring finger 1, transcript variant 2 (from RefSeq NM_029657.4) ENSMUST00000070658.1 ENSMUST00000070658.10 ENSMUST00000070658.11 ENSMUST00000070658.12 ENSMUST00000070658.13 ENSMUST00000070658.14 ENSMUST00000070658.15 ENSMUST00000070658.2 ENSMUST00000070658.3 ENSMUST00000070658.4 ENSMUST00000070658.5 ENSMUST00000070658.6 ENSMUST00000070658.7 ENSMUST00000070658.8 ENSMUST00000070658.9 Kiaa0544 MGRN1_MOUSE NM_029657 Q3U5V9 Q3UDA1 Q6ZQ97 Q8BZM9 Q9D074 uc007yap.1 uc007yap.2 uc007yap.3 uc007yap.4 E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity). Acts also as a negative regulator of hedgehog signaling (PubMed:29290584). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with MC1R and MC4R (By similarity). Interacts with TSG101. Interacts with mislocalized cytosolically exposed PRNP; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement. Early endosome te=The endosomal localization is dependent on the interaction with TSG101. [Isoform 1]: Cytoplasm. Cell membrane [Isoform 5]: Cytoplasm. Nucleus. Note=In the cytoplasm, predominantly localized to the perinuclear region and discrete vesicular structures. In the nucleus, broadly distributed, but excluded from nucleoli. Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=I; IsoId=Q9D074-1; Sequence=Displayed; Name=2; IsoId=Q9D074-2; Sequence=VSP_019854; Name=3; Synonyms=III; IsoId=Q9D074-3; Sequence=VSP_019856; Name=4; Synonyms=II; IsoId=Q9D074-4; Sequence=VSP_019855; Name=5; Synonyms=IV; IsoId=Q9D074-5; Sequence=VSP_019855, VSP_019856; Widely expressed, with highest levels in brain, heart, kidney and liver. In the CNS, especially prominent in the Purkinje cells of the cerebellum. In the skin, expressed in the basal layer of the epidermis and hair follicles, primarily in the outer root sheath. Isoforms 1, 3, 4 and 5 are equally expressed in the liver. Isoforms 1, 3 and 4 are most abundant in brain, kidney and heart, respectively. In presomite and early somite stage embryos, most strongly expressed in the node and more weakly in the neuroepithelium. In 6- to 12-somite embryos, strongest expression in the node, symmetrically in the floor plate of the neural tube and in the developing heart; weaker expression in paraxial mesoderm, somites, neuroepithelium, as well as in hind- and foregut pockets. By 9.5 dpc, virtually ubiquitous. The RING finger is required for ubiquitin ligase activity. Autoubiquitinated in vitro. Mutant mice have a pleiotropic phenotype that includes the absence of yellow hair pigment, curly hair and whiskers, abnormal craniofacial patterning, reduced embryonic viability due to mispatterning of the left-right body axis and age-dependent spongiform neurodegeneration. Many months before onset of vacuolation, mitochondrial complex IV expression and activity is significantly reduced in mutant brains and oxidative stress is increased. A global reduction of ubiquitinated proteins in the brain is observed. At 1 month of age, null mutant mouse brains have less ubiquitinated TSG101, while adult mutant brains contain more ubiquitinated and insoluble TSG101 than wild type. At 1 month of age, significant increase in EGFR levels in the brains of null mutant mice relative to wild-type mice, suggesting an impaired trafficking to the lysosome for degradation. [Isoform 1]: Sufficient for normal development, pigmentation and neuronal integrity. [Isoform 3]: Sufficient for normal development, pigmentation and neuronal integrity. [Isoform 4]: Partial rescue of the phenotype of mutant null mice. [Isoform 5]: Unable to rescue the phenotype of mutant null mice. This sequence has been deduced from the description in PubMed:19422019. protein polyubiquitination ubiquitin-protein transferase activity protein binding nucleus cytoplasm endosome early endosome plasma membrane protein monoubiquitination endosome to lysosome transport membrane protein ubiquitination transferase activity negative regulation of cAMP-mediated signaling negative regulation of G-protein coupled receptor protein signaling pathway negative regulation of smoothened signaling pathway metal ion binding ubiquitin protein ligase activity uc007yap.1 uc007yap.2 uc007yap.3 uc007yap.4 
ENSMUST00000070659.7 1700001K19Rik ENSMUST00000070659.7 RIKEN cDNA 1700001K19 gene (from RefSeq NM_025488.2) 1700001K19Rik ENSMUST00000070659.1 ENSMUST00000070659.2 ENSMUST00000070659.3 ENSMUST00000070659.4 ENSMUST00000070659.5 ENSMUST00000070659.6 NM_025488 Q80ZT1 Q80ZT1_MOUSE uc007pbp.1 uc007pbp.2 uc007pbp.3 uc007pbp.4 molecular_function cellular_component biological_process uc007pbp.1 uc007pbp.2 uc007pbp.3 uc007pbp.4 
ENSMUST00000070660.11 Misfa ENSMUST00000070660.11 mitochondrial sheath formation associated (from RefSeq NR_033461.1) A0A0N4SVS5 ENSMUST00000070660.1 ENSMUST00000070660.10 ENSMUST00000070660.2 ENSMUST00000070660.3 ENSMUST00000070660.4 ENSMUST00000070660.5 ENSMUST00000070660.6 ENSMUST00000070660.7 ENSMUST00000070660.8 ENSMUST00000070660.9 Gm9999 MISFA_MOUSE Misfa NR_033461 Q8C5Y2 uc291qde.1 uc291qde.2 [Isoform Kastor]: Regulates sperm development. May be involved in mitochondrial sheath formation. [Isoform Polluks]: Regulates sperm development. May be involved in mitochondrial sheath formation. [Isoform Kastor]: Interacts with VDAC3. [Isoform Polluks]: Interacts with VDAC3. [Isoform Kastor]: Mitochondrion outer membrane ; Single-pass membrane protein [Isoform Polluks]: Mitochondrion outer membrane ; Single-pass membrane protein Event=Alternative initiation; Named isoforms=2; Name=Kastor ; IsoId=Q8C5Y2-1; Sequence=Displayed; Name=Polluks ; IsoId=Q8C5Y2-2; Sequence=VSP_061801; [Isoform Kastor]: Testis specific. Detected only in germ cells at the step of spermiogenesis (at protein level). Expressed during the middle steps of spermatid development. [Isoform Polluks]: Testis specific. Detected only in germ cells at the step of spermiogenesis (at protein level). Expressed in the late steps of spermatid development. [Isoform Kastor]: Knockout mice are viable and manifest no substantial differences in body weight, testis weight or size, sperm count, or testicular histology. Although Kastor-deficient male mice are fertile, the number of pups produced by wild-type females after breeding with the mutant males is significantly reduced compared with that for wild-type males. The loss of Kastor induced a a nonuniform size of mitochondria and abnormal bending in spermatozoa. [Isoform Polluks]: Knockout mice are viable and manifest no substantial differences in body weight, testis weight or size, sperm count, or testicular histology. Although Polluks-deficient male mice are fertile, the number of pups produced by wild-type females after breeding with the mutant males is significantly reduced compared with that for wild-type males. The loss of Polluks results in irregular elongation and flattening of mitochondria without abnormal bending in spermatozoa. Isoform Kastor and isoform Polluks are conserved only in mammals. The locus MISFA encodes two different polypeptides Kastor and Polluks, with different transcription start sites and different ORFs. uc291qde.1 uc291qde.2 
ENSMUST00000070673.9 Rab31 ENSMUST00000070673.9 RAB31, member RAS oncogene family (from RefSeq NM_133685.2) ENSMUST00000070673.1 ENSMUST00000070673.2 ENSMUST00000070673.3 ENSMUST00000070673.4 ENSMUST00000070673.5 ENSMUST00000070673.6 ENSMUST00000070673.7 ENSMUST00000070673.8 NM_133685 Q8BKP0 Q921E2 RAB31_MOUSE uc008dgh.1 uc008dgh.2 uc008dgh.3 uc008dgh.4 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Interacts with OCRL. Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF). Interacts with EGFR (By similarity). Interacts with NGFR. Interacts (in GTP-bound form) with EEA1. Interacts (in GTP-bound form) with APPL2; interaction contributes to or enhances recruitment of APPL2 to the phagosomes; interaction enhances Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (PubMed:25568335). Early endosome Golgi apparatus, trans-Golgi network Golgi apparatus, trans-Golgi network membrane ; Lipid- anchor ; Cytoplasmic side Cytoplasmic vesicle, phagosome Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis. Detected in brain astrocytes (at protein level). Belongs to the small GTPase superfamily. Rab family. Sequence=AAH13063.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding phagocytic cup GTPase activity protein binding GTP binding cytoplasm endosome early endosome Golgi apparatus intracellular protein transport membrane GDP binding phagocytic vesicle membrane cytoplasmic vesicle receptor internalization Rab protein signal transduction trans-Golgi network membrane cellular response to insulin stimulus early phagosome membrane Golgi to plasma membrane protein transport regulated exocytosis phagocytic vesicle Golgi vesicle transport positive regulation of phagocytosis, engulfment phagosome maturation late endosome trans-Golgi network uc008dgh.1 uc008dgh.2 uc008dgh.3 uc008dgh.4 
ENSMUST00000070681.7 Gid4 ENSMUST00000070681.7 GID complex subunit 4, VID24 homolog (from RefSeq NM_025757.4) ENSMUST00000070681.1 ENSMUST00000070681.2 ENSMUST00000070681.3 ENSMUST00000070681.4 ENSMUST00000070681.5 ENSMUST00000070681.6 GID4_MOUSE NM_025757 Q3TP79 Q7TT31 Q99JE9 Q9CPY6 uc007jfw.1 uc007jfw.2 uc007jfw.3 uc007jfw.4 Substrate-recognition subunit of the CTLH E3 ubiquitin- protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly- Leu-Trp. Binds peptides with an N-terminal sequence of the type Pro- [Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind peptides with an acetylated N-terminal Pro residue. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. The first four residues of target peptides with a free N- terminal Pro (a Pro/N-degron) are bound inside a deep and narrow beta- barrel structure. Belongs to the GID4/VID24 family. The human orthologous sequence is longer in the N-terminus. Sequence=CAC34590.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; ubiquitin ligase complex protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin protein ligase activity uc007jfw.1 uc007jfw.2 uc007jfw.3 uc007jfw.4 
ENSMUST00000070690.8 Ptafr ENSMUST00000070690.8 platelet-activating factor receptor (from RefSeq NM_001081211.2) B1B170 ENSMUST00000070690.1 ENSMUST00000070690.2 ENSMUST00000070690.3 ENSMUST00000070690.4 ENSMUST00000070690.5 ENSMUST00000070690.6 ENSMUST00000070690.7 NM_001081211 PTAFR_MOUSE Q62035 Q8C017 uc008vbn.1 uc008vbn.2 uc008vbn.3 uc008vbn.4 This gene encodes a member of the G-protein coupled receptor 1 family of proteins. Binding of the encoded protein to its phospholipid ligand, platelet-activating factor (PAF), may regulate the inflammatory response and the perception of pain. Homozygous knockout mice for this gene exhibit impaired anaphylactic response, resistance to bacterial infection, and reduced pain-related behavior. [provided by RefSeq, Aug 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK032547.1, BY203963.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. Interacts with ARRB1. Cell membrane; Multi-pass membrane protein. Found in a range of organs. Expressed most strongly in spleen, followed by skeletal muscle, lung and small intestine. Expressed at moderate levels in the heart. Expressed at relatively low levels in the brain, liver and kidney. By lipopolysaccharide (LPS). Belongs to the G-protein coupled receptor 1 family. lipopolysaccharide binding cytokine production lipopolysaccharide receptor activity positive regulation of cellular extravasation G-protein coupled receptor activity platelet activating factor receptor activity phospholipid binding plasma membrane regulation of transcription from RNA polymerase II promoter chemotaxis inflammatory response signal transduction G-protein coupled receptor signaling pathway parturition response to symbiotic bacterium positive regulation of phospholipase C activity membrane integral component of membrane lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide positive regulation of tumor necrosis factor production inositol trisphosphate biosynthetic process G-protein coupled purinergic nucleotide receptor signaling pathway positive regulation of neutrophil degranulation G-protein coupled purinergic nucleotide receptor activity transcytosis positive regulation of interleukin-6 biosynthetic process positive regulation of translation negative regulation of blood pressure positive regulation of vasoconstriction positive regulation of smooth muscle contraction response to organophosphorus phosphatidylinositol-mediated signaling positive regulation of smooth muscle cell proliferation mitogen-activated protein kinase binding positive regulation of inositol phosphate biosynthetic process cellular response to gravity cellular response to cAMP cellular response to fatty acid response to dexamethasone positive regulation of voltage-gated chloride channel activity positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte tethering or rolling positive regulation of sensory perception of pain positive regulation of transcytosis positive regulation of maternal process involved in parturition positive regulation of gastro-intestinal system smooth muscle contraction response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine uc008vbn.1 uc008vbn.2 uc008vbn.3 uc008vbn.4 
ENSMUST00000070709.9 Rell2 ENSMUST00000070709.9 RELT-like 2 (from RefSeq NM_153793.2) ENSMUST00000070709.1 ENSMUST00000070709.2 ENSMUST00000070709.3 ENSMUST00000070709.4 ENSMUST00000070709.5 ENSMUST00000070709.6 ENSMUST00000070709.7 ENSMUST00000070709.8 NM_153793 Q8BRJ3 RELL2_MOUSE uc008ern.1 uc008ern.2 uc008ern.3 Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed. Interacts with RELT, RELL1, OXSR1, PLSCR1 and TRAF2. Cell membrane ; Single-pass membrane protein Belongs to the RELT family. collagen binding basement membrane plasma membrane positive regulation of cell-substrate adhesion membrane integral component of membrane extracellular matrix positive regulation of p38MAPK cascade uc008ern.1 uc008ern.2 uc008ern.3 
ENSMUST00000070722.3 Defb21 ENSMUST00000070722.3 defensin beta 21, transcript variant 1 (from RefSeq NM_207276.3) Defb21 ENSMUST00000070722.1 ENSMUST00000070722.2 NM_207276 Q8C5Z4 Q8C5Z4_MOUSE uc008nfr.1 uc008nfr.2 uc008nfr.3 Has antibacterial activity. Secreted Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium innate immune response uc008nfr.1 uc008nfr.2 uc008nfr.3 
ENSMUST00000070726.10 Slc39a6 ENSMUST00000070726.10 solute carrier family 39 (metal ion transporter), member 6 (from RefSeq NM_139143.3) ENSMUST00000070726.1 ENSMUST00000070726.2 ENSMUST00000070726.3 ENSMUST00000070726.4 ENSMUST00000070726.5 ENSMUST00000070726.6 ENSMUST00000070726.7 ENSMUST00000070726.8 ENSMUST00000070726.9 NM_139143 Q7TPP9 Q7TQE0 Q8C145 Q8R518 S39A6_MOUSE Slc39a6 Zip6 uc008egv.1 uc008egv.2 Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:28098160). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (By similarity). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (PubMed:28098160). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as E-cadherin, causing loss of cell adherence (By similarity). In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (By similarity). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (By similarity). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461). Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence=; Interacts with SLC39A10; which triggers cells to undergo EMT and mitosis. Found in a complex with SLC39A6, SLC39A10 and with the 'Ser-727' phosphorylated form of STAT3 throughout mitosis (By similarity). Found in a complex with SLC39A6, SLC39A10 and with NCAM1; this complex controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition (EMT) (PubMed:28098160). Found in a complex with SLC39A6, SLC39A10 and with GSK3B that controls NCAM1 phosphorylation (PubMed:28098160). Cell membrane ; Multi-pass membrane protein Cell projection, lamellipodium membrane ; Multi-pass membrane protein Membrane raft ; Multi-pass membrane protein Apical cell membrane Note=Localizes to lipid rafts in T cells and is recruited into the immunological synapse in response to TCR stimulation (By similarity). In the choroid plexus is limited to the apical membrane in epithelial cells (By similarity). Highly expressed in the brain and testis. In the brain strongly expressed in the CA1 and CA3 regions, Purkinje cells in cerebellum and dentate gyrus in hippocampus. In testis found in spermatids or mature sperms in the central areas of seminiferous tubules. Highly expressed in the oocyte and egg but decreased and remained low after fertilization (PubMed:25143461). During preimplantation embryos, localizes to the cortex (PubMed:25143461). Induced during neuronal differentiation neuroblastoma cells line but down-regulated during myogenic differentiation of skeletal muscle cells line (PubMed:11891044). Induced during epithelialto- mesenchymal transition (EMT) (PubMed:28098160). Cleaved on the N-terminus before locating to the plasma membrane. N-glycosylated. Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation. Belongs to the ZIP transporter (TC 2.A.5) family. Sequence=AAH54780.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB86300.1; Type=Frameshift; Evidence=; zinc ion transmembrane transporter activity endoplasmic reticulum plasma membrane integral component of plasma membrane ion transport zinc II ion transport cellular zinc ion homeostasis membrane integral component of membrane metal ion transport lamellipodium membrane metal ion transmembrane transporter activity transmembrane transport zinc II ion transmembrane transport zinc II ion transmembrane import uc008egv.1 uc008egv.2 
ENSMUST00000070733.9 Ptprn2 ENSMUST00000070733.9 protein tyrosine phosphatase receptor type N polypeptide 2 (from RefSeq NM_011215.2) ENSMUST00000070733.1 ENSMUST00000070733.2 ENSMUST00000070733.3 ENSMUST00000070733.4 ENSMUST00000070733.5 ENSMUST00000070733.6 ENSMUST00000070733.7 ENSMUST00000070733.8 NM_011215 O09134 P70328 P80560 PTPR2_MOUSE Q1RLJ1 uc007phx.1 uc007phx.2 uc007phx.3 uc007phx.4 Plays a role in vesicle-mediated secretory processes (PubMed:21732083). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:21732083). Plays a role in insulin secretion in response to glucose stimuli (PubMed:15220191, PubMed:16418280, PubMed:21732083). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (PubMed:16269463). Required to maintain normal levels of renin expression and renin release (PubMed:19019914). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (PubMed:12364328). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Self-associates. Interacts (via cytoplasmic domain) with PTPRN (via cytoplasmic domain) (PubMed:12364328). Interacts (precursor form) with CPE (PubMed:21210912). Interacts with HAP1 isoform A (PubMed:21544547). Interacts with AP2A1 or AP2A2 and AP1G1; indicative for an association with adaptor protein complex 2 (AP-2) and adaptor protein complex 1 (AP-1) (PubMed:16262730). Interacts with AP2M1; indicative for an association with adaptor protein complex 2 (AP-2). Interacts with MYO5A (By similarity). P80560; Q60673: Ptprn; NbExp=4; IntAct=EBI-8538944, EBI-8328895; Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass type I membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein Note=Predominantly found on dense-core secretory granules. Sorting to secretory granules in part is dependent of the N- terminal pro domain of the precursor and its interaction with CPE. Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles involving clathrin-dependent AP2- mediated endocytosis. Recycled via STX6- but not TTTGN1/TGN38- containing compartments. [IA-2beta60]: Cytoplasmic vesicle, secretory vesicle membrane Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Type 1-PTP-NP; IsoId=P80560-1; Sequence=Displayed; Name=2; Synonyms=Type 2-PTP-NP; IsoId=P80560-2; Sequence=Not described; Detected in brain (PubMed:15220191, PubMed:19361477). Detected in pancreas islets (at protein level) (PubMed:8681804). Detected in pancreas and brain (PubMed:8681804, PubMed:8637868). Expressed in early stages of pancreatic development. First expressed in 8.5 dpc embryos in the dorsal part of the midgut endoderm and by 9.5 dpc, in the pancreatic rudiment specifically in early endocrine progenitor cells. At later stages expressed in insulin- or glucagon-producing cells. During neural development, the type 2 PTP-NP is expressed in early stages of neurogenesis, and the type 1 weakly in the later stages. By GHRL in brain, pancreas, and insulinoma cell lines. The tyrosine-based internalization signal is proposed to function in clathrin-mediated endocytosis and recycling. The leucine-based sorting signal is proposed to function in trafficking at the plasma membrane. Subject to proteolytic cleavage at multiple sites during maturation of secretory granules. In the brain at least IA-2beta71, IA- 2beta64 and IA-2beta60 have been detected, in the pancreas and a pancreatic beta cell line only IA-2beta60 has been detected. Mice appear healthy and normal, but display mildly decreased glucose tolerance and impaired glucose-stimulated insulin secretion (PubMed:15220191). Pancreatic islets from mice lacking both Ptprn and Ptprn2 contain decreased numbers of insulin- containing vesicles and show a further decrease in insulin secretion after glucose stimuli (PubMed:21732083). Mice lacking both Ptprn and Ptprn2 appear normal, but have lower levels of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. Likewise, they have decreased numbers of synaptic vesicles in the hippocampus and show decreased neurotransmitter release after K(+) stimulation; basal levels of neurotransmitter release are unaffected. They show increased anxiety-like behavior with strongly decreased exploratory activity and rearing. Besides, they show defects in remembering conditioned learning. With increasing age, mutant mice develop a tendency to suffer seizures and display a reduced life span; roughly half of the mutant mice are dead after 40 weeks (PubMed:19361477). The majority of female mice deficient in both Ptprn and Ptprn2 are infertile or have small litters, due to abnormalities of the estrous cycle and absence of corpora lutea. These defects are due to decreased levels of luteinizing hormone and follicle-stimulating hormone (FSH) in the pituitary and decreased levels of luteinizing hormone (LH) in the blood plasma. In contrast, male mice lacking both Ptprn and Ptprn2 display normal hormone levels and normal fertility (PubMed:16269463). Belongs to the protein-tyrosine phosphatase family. Has no tyrosine-protein phosphatase activity at mild acidic conditions (pH 5.5). The in vivo relevance of the low PPase activity for the human protein at acidic conditions (pH 4.5) is questioned. This catalytic activity seems to be affected by the replacement of a highly conserved residue in the tyrosine-protein phosphatase domain. phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding cytoplasm endoplasmic reticulum lumen protein dephosphorylation lipid metabolic process neurotransmitter secretion membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity cell junction secretory granule integral component of synaptic vesicle membrane transport vesicle membrane secretory granule membrane synaptic vesicle membrane cytoplasmic vesicle negative regulation of GTPase activity peptidyl-tyrosine dephosphorylation insulin secretion involved in cellular response to glucose stimulus terminal bouton receptor complex synapse uc007phx.1 uc007phx.2 uc007phx.3 uc007phx.4 
ENSMUST00000070735.10 Gabrg2 ENSMUST00000070735.10 gamma-aminobutyric acid type A receptor, subunit gamma 2, transcript variant 1 (from RefSeq NM_008073.4) ENSMUST00000070735.1 ENSMUST00000070735.2 ENSMUST00000070735.3 ENSMUST00000070735.4 ENSMUST00000070735.5 ENSMUST00000070735.6 ENSMUST00000070735.7 ENSMUST00000070735.8 ENSMUST00000070735.9 GBRG2_MOUSE NM_008073 P22723 Q91V50 Q91VA8 uc007imb.1 uc007imb.2 uc007imb.3 uc007imb.4 This gene encodes a gamma-aminobutyric acid (GABA)-A receptor subunit, which is a member of the ligand-gated ion channel family. GABA is the major inhibitory neurotransmitter in the adult central nervous system, and conversely exhibits an excitatory function during development. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. This gene encodes one of three gamma subunits in mammals, which contain the binding site for benzodiazepine drugs. Several mutations in this gene are associated with epileptic seizures, and genetic knockdown is associated with anxiety behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:27129275). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:27129275). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275). The alpha1/beta2/gamma2 receptor, alpha2/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (PubMed:27129275). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Allosterically activated by benzodiazepines (By similarity). Activated by pentobarbitol (By similarity). Inhibited by the antagonist bicuculline (By similarity). Inhibited by zinc ions (By similarity). Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (PubMed:18281286). Interacts with GABARAP (By similarity). Interacts with KIF21B (By similarity). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Interacts with LHFPL4 (PubMed:28978485, PubMed:29742426). Interacts with SHISA7; interaction leads to the regulation of GABA(A) receptor trafficking, channel deactivation kinetics and pharmacology (PubMed:31601770). Postsynaptic cell membrane ; Multi-pass membrane protein Cell membrane ulti-pass membrane protein Cell projection, dendrite Cytoplasmic vesicle membrane Event=Alternative splicing; Named isoforms=2; Name=2L; IsoId=P22723-1; Sequence=Displayed; Name=2S; IsoId=P22723-2; Sequence=VSP_000091; Expressed in brain neurons (at protein level). The extracellular domain contributes to synaptic contact formation. Glycosylated. Palmitoylated by ZDHHC3/GODZ; required for the accumulation of GABA(A) receptors at the postsynaptic membrane of inhibitory GABAergic synapses. This subunit carries the benzodiazepine binding site. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub- subfamily. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity inhibitory extracellular ligand-gated ion channel activity chloride channel activity protein binding cytoplasm plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction gamma-aminobutyric acid signaling pathway chemical synaptic transmission post-embryonic development membrane integral component of membrane GABA-gated chloride ion channel activity cell junction axon dendrite adult behavior cytoplasmic vesicle membrane cytoplasmic vesicle dendrite membrane ion transmembrane transport chloride channel complex regulation of membrane potential cell projection neuron projection synapse postsynaptic membrane neurological system process synaptic transmission, GABAergic inhibitory synapse regulation of postsynaptic membrane potential cellular response to histamine postsynapse glutamatergic synapse GABA-ergic synapse integral component of postsynaptic specialization membrane chloride transmembrane transport GABA receptor complex GABA-A receptor complex transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential inhibitory synapse assembly benzodiazepine receptor activity GABA receptor activity uc007imb.1 uc007imb.2 uc007imb.3 uc007imb.4 
ENSMUST00000070742.14 Cgas ENSMUST00000070742.14 cyclic GMP-AMP synthase, transcript variant 2 (from RefSeq NR_125721.1) CGAS_MOUSE Cgas ENSMUST00000070742.1 ENSMUST00000070742.10 ENSMUST00000070742.11 ENSMUST00000070742.12 ENSMUST00000070742.13 ENSMUST00000070742.2 ENSMUST00000070742.3 ENSMUST00000070742.4 ENSMUST00000070742.5 ENSMUST00000070742.6 ENSMUST00000070742.7 ENSMUST00000070742.8 ENSMUST00000070742.9 Mb21d1 NR_125721 Q3ULW3 Q8C6L5 uc009quj.1 uc009quj.2 uc009quj.3 uc009quj.4 The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:23258413, PubMed:23647843, PubMed:23722158, PubMed:26829768, PubMed:28214358, PubMed:29625897, PubMed:29426904, PubMed:32814054). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:23258413, PubMed:23647843, PubMed:23722158, PubMed:26829768, PubMed:28214358). Acts as a key DNA sensor: directly binds double- stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:23722158, PubMed:28314590, PubMed:28363908, PubMed:28095500). Preferentially binds long dsDNA (around 45 bp) and forms ladder-like networks that function cooperatively to stabilize individual cGAS-dsDNA complexes (PubMed:28902841). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:23722158, PubMed:28314590, PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:23258413, PubMed:23722158, PubMed:23647843). Also acts as an innate immune sensor of infection by retroviruses by detecting the presence of reverse- transcribed DNA in the cytosol (PubMed:23929945). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse- transcribed retroviral DNA (By similarity). Also detects the presence of DNA from bacteria (By similarity). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS- independent but STING1-dependent manner (PubMed:26229117). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (By similarity). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759028). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (PubMed:28759028). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408). Micronuclei, which as frequently found in cancer cells, consist of chromatin surrounded by its own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (By similarity). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31808743, PubMed:32911481, PubMed:32911480, PubMed:32913000). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964, PubMed:35210392). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (By similarity). Reaction=ATP + GTP = 2',3'-cGAMP + 2 diphosphate; Xref=Rhea:RHEA:42064, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:143093; EC=2.7.7.86; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42065; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mg(2+) per subunit (PubMed:23647843). Is also active with Mn(2+) (PubMed:23647843, PubMed:32814054). Mn(2+)-activated enzyme forms an inverted pppGp(2'-5')A intermediate, suggesting a non- canonical but accelerated 2',3'-cGAMP cyclization without substrate flip-over (PubMed:32814054). Mn(2+) ions are coordinated by triphosphate moiety of the inverted substrate, independent of the catalytic triad residues (PubMed:32814054). ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Note=Undergoes a liquid-like phase transition after binding to DNA, which is dependent on zinc. ; The enzyme activity is strongly increased by double-stranded DNA (dsDNA), but not by single-stranded DNA or RNA (By similarity). DNA-binding induces the formation of liquid-like droplets in which CGAS is activated (By similarity). Liquid-like droplets also create a selective environment that restricts entry of negative regulators, such as TREX1 or BANF1/BAF, allowing sensing of DNA (By similarity). A number of mechanisms exist to restrict its activity toward self-DNA (PubMed:32911481, PubMed:32911480, PubMed:32913000). The nucleotidyltransferase activity is inhibited in the nucleus via its association with nucleosomes: interacts with the acidic patch of histones H2A and H2B, thereby blocking DNA-binding and subsequent activation (PubMed:32156810, PubMed:32911481, PubMed:32911480, PubMed:32913000). CGAS is also inactive when associated with mitotic chromatin (By similarity). Chromatin-bound CGAS cannot be activated by exogenous DNA in mitotic cells: phosphorylation of the N-terminal disordered part by AURKB during the G2-M transition blocks CGAS liquid phase separation and activation (By similarity). Activity toward self- DNA is inhibited by BANF1/BAF upon acute loss of nuclear membrane integrity: BANF1/BAF acts by outcompeting CGAS for DNA-binding, thereby preventing CGAS activation (PubMed:32156810). DNA-induced activation at micronuclei is also limited by TREX1, which degrades micronuclear DNA upon nuclear envelope rupture, thereby preventing CGAS activation (By similarity). Acetylation at Lys-372, Lys-382 and Lys-402 inhibits the cyclic GMP-AMP synthase activity (By similarity). Acetylation by KAT5 increases the cyclic GMP-AMP synthase activity by promoting DNA-binding and subsequent activation (By similarity). Phosphorylation at Ser-291 suppresses the nucleotidyltransferase activity (PubMed:26440888). Phosphorylation at Ser-420 promotes the cyclic GMP-AMP synthase activity (PubMed:32474700). Phosphorylation at Thr-52 and Ser-199 inhibits its cyclic GMP-AMP synthase activity (By similarity). Ubiquitination at Lys-372 via 'Lys-27'-linked polyubiquitination enhances the cyclic GMP-AMP synthase activity (By similarity). Monoubiquitination at Lys-335 promotes oligomerization and subsequent activation (PubMed:29426904). Sumoylation at Lys-335, Lys-372 and Lys- 382 prevents DNA-binding, oligomerization and nucleotidyltransferase activity (PubMed:28095500). The enzyme activity is impaired by the cleavage by CASP1 (PubMed:28314590). In addition to DNA, also activated by collided ribosomes upon translation stress: specifically binds collided ribosomes, promoting its activation and triggering type-I interferon production (By similarity). In hematopoietic stem cells, binding to circular RNA cia-cGAS inhibits the cyclic GMP-AMP synthase activity (PubMed:29625897). Strongly inhibited by compound RU.521, which is specific for mouse protein (PubMed:28963528, PubMed:30007416). Monomer in the absence of DNA (PubMed:28214358). Homodimer in presence of dsDNA: forms a 2:2 dimer with two enzymes binding to two DNA molecules (PubMed:29426904, PubMed:28902841). Interacts with nucleosomes; interaction is mainly mediated via histones H2A and H2B and inactivates the nucleotidyltransferase activity by blocking DNA- binding and subsequent activation (PubMed:32911481, PubMed:32911480, PubMed:32913000). Interacts with PQBP1 (via WW domain) (By similarity). Interacts with TRIM14; this interaction recruits USP14, leading to deubiquitinate and stabilize CGAS and promote type I interferon production (By similarity). Interacts with ZCCHC3; promoting sensing of dsDNA by CGAS (By similarity). Interacts (when not monomethylated) with (poly-ADP-ribosylated) PARP1; interaction takes place in the nucleus and prevents the formation of the PARP1-TIMELESS complex (PubMed:35210392). Interacts (when monomethylated) with SGF29; interaction with SGF29 prevents interaction with PARP1 (PubMed:35210392). Interacts with PCBP2; preventing the formation of liquid-like droplets in which CGAS is activated (By similarity). Interacts with Irgm1; promoting CGAS degradation (By similarity). Nucleus romosome ll membrane ; Peripheral membrane protein Cytoplasm, cytosol te=Mainly localizes in the nucleus, and at low level in the cytosol (PubMed:31808743, PubMed:31544964). On chromosomes, enriched on centromeric satellite and LINE DNA repeat elements (By similarity). Exported from the nucleus to the cytosol in a XPO1/CRM1 via the nuclear export signal in response to DNA stimulation (By similarity). Outside the nucleus, localizes at the cell membrane as a peripheral membrane protein in resting conditions: association to the cell membrane is mediated via binding to phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2) (PubMed:30827685). Localization at the cell membrane is required to limit the recognition of self-DNA (By similarity). Following detection of double-stranded DNA (dsDNA), released from the cell membrane into the cytosol in order to signal (By similarity). Upon transfection with dsDNA forms punctate structures that co-localize with DNA and Beclin-1 (BECN1) (By similarity). Phosphorylation at Tyr-201 promotes cytosolic retention (By similarity). In response to translation stress, translocates to the cytosol and associates with collided ribosomes (By similarity). The N-terminal disordered part (1-146) binds unspecifically dsDNA and expand the binding and moving range of CGAS on dsDNA (PubMed:28214358, PubMed:28314590, PubMed:28363908). The disordered and positively charged residues enhance CGAS-DNA phase separation by increasing the valencies of DNA-binding (By similarity). The N-terminus is required to sense chromatin and its phosphorylation blocks its activation by chromatin DNA (By similarity). When the N-terminal part (1-146) is missing the protein bound to dsDNA homodimerizes (PubMed:28214358). The arginine-anchor tightly binds to the canonical H2A acidic- patch residues. The N-terminal disordered part (1-146) is phosphorylated by AURKB during the G2-M transition, blocking CGAS liquid phase separation and preventing activation (By similarity). Phosphorylation at Tyr-201 by BLK promotes cytosolic retention (By similarity). Localizes into the nucleus following dephosphorylation at Tyr-201 (By similarity). Phosphorylation at Ser-420 activates the nucleotidyltransferase activity (PubMed:32474700). Dephosphorylation at Ser-420 by PPP6C impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700). Phosphorylation at Thr-52 and Ser-199 by PRKDC inhibits its cyclic GMP-AMP synthase activity by impairing homodimerization and activation (By similarity). Phosphorylation at Ser-291 by AKT (AKT1, AKT2 or AKT3) suppresses the nucleotidyltransferase activity (PubMed:26440888). Phosphorylation at Ser-291 by CDK1 during mitosis leads to its inhibition, thereby preventing CGAS activation by self-DNA during mitosis (PubMed:32351706). Dephosphorylated at Ser-291 by protein phosphatase PP1 upon mitotic exit (PubMed:32351706). Ubiquitinated at Lys-402 via 'Lys-48'-linked polyubiquitin chains, leading to its SQSTM1-mediated autophagic degradation (By similarity). Interaction with TRIM14 promotes recruitment of USP14, leading to deubiquitinate Lys-402 and stabilize CGAS (By similarity). Ubiquitinated at Lys-372 by RNF185 via 'Lys-27'-linked polyubiquitination, promoting CGAS cyclic GMP-AMP synthase activity (By similarity). Monoubiquitination at Lys-335 by TRIM56 promotes oligomerization and subsequent activation (PubMed:29426904). Monoubiquitination by TRIM41 promotes CGAS activation (By similarity). Ubiquitination at Lys-271 and Lys-464 via 'Lys-48'-linked polyubiquitination promotes its degradation (PubMed:32457395, PubMed:27637147). Deubiquitination at Lys-271 by USP29 promotes its stabilization (PubMed:32457395). Deubiquitinated by USP27X, promoting its stabilization (PubMed:31534008). Ubiquitinated at Lys-399 via 'Lys- 63'-linked polyubiquitin chains by MARCHF8, leading to the inhibition of its DNA binding ability (By similarity). Sumoylated at Lys-217 and Lys-464 by TRIM38 in uninfected cells and during the early phase of viral infection, promoting its stability by preventing ubiquitination at Lys-271 and Lys-464, and subsequent degradation (PubMed:27637147). Desumoylated by SENP2 during the late phase of viral infection (PubMed:27637147). Sumoylation at Lys-335, Lys-372 and Lys-382 prevents DNA-binding, oligomerization and nucleotidyltransferase activity (PubMed:28095500). Desumoylation at Lys-335, Lys-372 and Lys-382 by SENP7 relieves inhibition and activates CGAS (PubMed:28095500). Polyglutamylated by TTLL6 at Glu-272, leading to impair DNA- binding activity. Monoglutamylated at Glu-302 by TTLL4, leading to impair the nucleotidyltransferase activity. Deglutamylated by AGBL5/CCP5 and AGBL6/CCP6. Acetylation at Lys-372, Lys-382 and Lys-402 inhibits the cyclic GMP-AMP synthase activity. Deacetylated upon cytosolic DNA challenge such as viral infections. Acetylation by KAT5 increases the cyclic GMP- AMP synthase activity by promoting DNA-binding and subsequent activation. Proteolytically cleaved by apoptotic caspases during apoptosis, leading to its inactivation (PubMed:25525874, PubMed:30878284). The damage of the nucleus and the mitochondria during apoptosis leads to leakage of nuclear and mitochondrial DNA, which activate CGAS: cleavage and inactivation during apoptosis in required to prevent cytokine overproduction (PubMed:25525874). Cleaved by CASP7 and CASP3 during virus-induced apoptosis, thereby inactivating it and preventing cytokine overproduction (PubMed:30878284). Cleaved by CASP1 upon DNA virus infection; the cleavage impairs cGAMP production (PubMed:28314590). Also cleaved by the pyroptotic CASP4 during non- canonical inflammasome activation; does not cut at the same sites than CASP1 (PubMed:28314590). Degraded via selective autophagy following interaction with Irgm1. Irgm1 promotes CGAS recruitment to autophagosome membranes, promoting its SQSTM1/p62-dependent autophagic degradation. Poly-ADP-ribosylation at Glu-176 by PARP1 impairs DNA-binding, thereby preventing the cyclic GMP-AMP synthase activity. Palmitoylation at Cys-459 by ZDHHC18 impairs DNA-binding, thereby preventing the cyclic GMP-AMP synthase activity. Monomethylated at Lys-491 by SETD7 (PubMed:35210392). Monomethylation promotes interaction with SGF29, preventing interaction between PARP1 nad SGF29 (PubMed:35210392). Demethylation by RIOX1 promotes interaction with PARP1, followed by PARP1 inactivation (PubMed:35210392). Belongs to the mab-21 family. Was reported to homodimerize in presence of double-stranded DNA (dsDNA) (PubMed:24332030). However, this result was based on a structure lacking the N-terminal part (1-146), which caused homodimerization in presence of dsDNA (PubMed:28214358). nucleotide binding activation of innate immune response positive regulation of defense response to virus by host immune system process regulation of immunoglobulin production DNA binding chromatin binding double-stranded DNA binding protein binding ATP binding GTP binding phosphatidylinositol-4,5-bisphosphate binding nucleus cytoplasm cytosol plasma membrane DNA repair cellular response to DNA damage stimulus lipid binding determination of adult lifespan positive regulation of cGMP-mediated signaling membrane transferase activity nucleotidyltransferase activity regulation of type I interferon production positive regulation of type I interferon production site of double-strand break paracrine signaling positive regulation of cAMP-mediated signaling innate immune response metal ion binding regulation of immune response regulation of T cell activation defense response to virus cyclic-GMP-AMP synthase activity cellular response to exogenous dsRNA negative regulation of double-strand break repair via homologous recombination positive regulation of cellular senescence uc009quj.1 uc009quj.2 uc009quj.3 uc009quj.4 
ENSMUST00000070748.10 Ldb2 ENSMUST00000070748.10 LIM domain binding 2, transcript variant 1 (from RefSeq NM_010698.4) Clim1 ENSMUST00000070748.1 ENSMUST00000070748.2 ENSMUST00000070748.3 ENSMUST00000070748.4 ENSMUST00000070748.5 ENSMUST00000070748.6 ENSMUST00000070748.7 ENSMUST00000070748.8 ENSMUST00000070748.9 LDB2_MOUSE NM_010698 O55203 O55205 Q3UHY1 Q6AXE6 uc008xit.1 uc008xit.2 uc008xit.3 uc008xit.4 Transcription cofactor (PubMed:9192866). Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors (PubMed:9192866). [Isoform 1]: Regulates the transcriptional activity of LIM- containing proteins such as LHX3 or PITX1. Interacts with LHX9 (PubMed:10330499). Interacts with SLK; leading to negatively regulate SLK kinase activity (PubMed:19675209). Interacts with LMO4 (PubMed:9860983). [Isoform 1]: Interacts with PITX1 (PubMed:9192866). Interacts with LHX3 (PubMed:9192866). O55203; Q9WTV7: Rlim; NbExp=2; IntAct=EBI-15657830, EBI-15657872; Nucleus Note=Colocalizes with SLK at leading edges (PubMed:19675209). [Isoform 1]: Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CLIM-1a; IsoId=O55203-1; Sequence=Displayed; Name=2; Synonyms=CLIM-1b; IsoId=O55203-2; Sequence=VSP_014369, VSP_014370; Name=3; IsoId=O55203-3; Sequence=VSP_027829, VSP_014369, VSP_014370; Expressed in multiple tissues including heart, brain, liver, kidney, testis, lung and muscle, with expression highest in the brain, trigeminal ganglia, and lung. Expression in the embryo overlaps that of LIM domain-containing proteins (PubMed:9192866). Expressed widely in the embryo with highest expression in several regions of the brain, and the central nervous system ganglia (PubMed:9192866). Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. [Isoform 2]: Lacks LIM-binding domain. Belongs to the LDB family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding hair follicle development transcription cofactor activity protein binding nucleus transcription factor complex nucleolus plasma membrane regulation of transcription from RNA polymerase II promoter multicellular organism development epithelial structure maintenance enzyme binding LIM domain binding regulation of cell migration cell leading edge somatic stem cell population maintenance regulation of kinase activity positive regulation of cellular component biogenesis negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc008xit.1 uc008xit.2 uc008xit.3 uc008xit.4 
ENSMUST00000070755.13 Rad54b ENSMUST00000070755.13 RAD54 homolog B (S. cerevisiae), transcript variant 1 (from RefSeq NM_001039556.4) A2AIV0 ENSMUST00000070755.1 ENSMUST00000070755.10 ENSMUST00000070755.11 ENSMUST00000070755.12 ENSMUST00000070755.2 ENSMUST00000070755.3 ENSMUST00000070755.4 ENSMUST00000070755.5 ENSMUST00000070755.6 ENSMUST00000070755.7 ENSMUST00000070755.8 ENSMUST00000070755.9 NM_001039556 Q6PFE3 RA54B_MOUSE uc008rzs.1 uc008rzs.2 uc008rzs.3 uc008rzs.4 Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group. Interacts with RAD51 through the NH2-terminal domain. Nucleus Belongs to the SNF2/RAD54 helicase family. nucleotide binding double-strand break repair via homologous recombination DNA binding helicase activity ATP binding nucleus DNA repair cellular response to DNA damage stimulus reciprocal meiotic recombination determination of adult lifespan response to ionizing radiation DNA translocase activity hydrolase activity response to drug uc008rzs.1 uc008rzs.2 uc008rzs.3 uc008rzs.4 
ENSMUST00000070756.12 Adcyap1r1 ENSMUST00000070756.12 adenylate cyclase activating polypeptide 1 receptor 1, transcript variant 2 (from RefSeq NM_001025372.2) Adcyap1r1 ENSMUST00000070756.1 ENSMUST00000070756.10 ENSMUST00000070756.11 ENSMUST00000070756.2 ENSMUST00000070756.3 ENSMUST00000070756.4 ENSMUST00000070756.5 ENSMUST00000070756.6 ENSMUST00000070756.7 ENSMUST00000070756.8 ENSMUST00000070756.9 NM_001025372 Q6NXJ9 Q6NXJ9_MOUSE uc009cau.1 uc009cau.2 uc009cau.3 uc009cau.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 2 family. transmembrane signaling receptor activity G-protein coupled receptor activity vasoactive intestinal polypeptide receptor activity signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway membrane integral component of membrane uc009cau.1 uc009cau.2 uc009cau.3 uc009cau.4 
ENSMUST00000070758.10 Mpz ENSMUST00000070758.10 Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. (from UniProt E9QK82) AK089180 E9QK82 E9QK82_MOUSE ENSMUST00000070758.1 ENSMUST00000070758.2 ENSMUST00000070758.3 ENSMUST00000070758.4 ENSMUST00000070758.5 ENSMUST00000070758.6 ENSMUST00000070758.7 ENSMUST00000070758.8 ENSMUST00000070758.9 Mpz uc007dnc.1 uc007dnc.2 uc007dnc.3 uc007dnc.4 Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. Homodimer and homotetramer. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the myelin P0 protein family. lysosome rough endoplasmic reticulum plasma membrane integral component of plasma membrane membrane integral component of membrane basolateral plasma membrane myelination negative regulation of apoptotic process myelin sheath cell-cell adhesion via plasma-membrane adhesion molecules cell aggregation uc007dnc.1 uc007dnc.2 uc007dnc.3 uc007dnc.4 
ENSMUST00000070797.7 Pcdha1 ENSMUST00000070797.7 protocadherin alpha 1 (from RefSeq NM_054072.1) ENSMUST00000070797.1 ENSMUST00000070797.2 ENSMUST00000070797.3 ENSMUST00000070797.4 ENSMUST00000070797.5 ENSMUST00000070797.6 NM_054072 Pcdha1 Q91Y21 Q91Y21_MOUSE uc008eot.1 uc008eot.2 uc008eot.3 uc008eot.4 uc008eot.5 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding endoplasmic reticulum plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eot.1 uc008eot.2 uc008eot.3 uc008eot.4 uc008eot.5 
ENSMUST00000070801.11 Alg13 ENSMUST00000070801.11 asparagine-linked glycosylation 13, transcript variant 1 (from RefSeq NM_026247.3) A3KGC8 A3KGD0 A3KGD1 ALG13_MOUSE ENSMUST00000070801.1 ENSMUST00000070801.10 ENSMUST00000070801.2 ENSMUST00000070801.3 ENSMUST00000070801.4 ENSMUST00000070801.5 ENSMUST00000070801.6 ENSMUST00000070801.7 ENSMUST00000070801.8 ENSMUST00000070801.9 Glt28d1 NM_026247 Q8BUA4 Q9D5Z6 Q9D8C3 uc009ums.1 uc009ums.2 uc009ums.3 uc009ums.4 [Isoform 1]: Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities. [Isoform 2]: May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway (By. similarity). Reaction=N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N- acetyl-alpha-D-glucosamine = H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP; Xref=Rhea:RHEA:23380, Rhea:RHEA-COMP:9519, Rhea:RHEA-COMP:9520, ChEBI:CHEBI:15378, ChEBI:CHEBI:57269, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:58427; EC=2.4.1.141; Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Isoform 2 may interact with ALG14. Endoplasmic reticulum Note=Could be recruited to the cytosolic face of the endoplasmic reticulum membrane through its interaction with ALG14. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D8C3-1; Sequence=Displayed; Name=2; IsoId=Q9D8C3-2; Sequence=VSP_039304, VSP_039305; Belongs to the glycosyltransferase 28 family. Sequence=CAM45938.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM45939.1; Type=Erroneous gene model prediction; Evidence=; catalytic activity N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity endoplasmic reticulum dolichol-linked oligosaccharide biosynthetic process proteolysis metabolic process peptidase activity cysteine-type peptidase activity transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups hydrolase activity thiol-dependent ubiquitinyl hydrolase activity uc009ums.1 uc009ums.2 uc009ums.3 uc009ums.4 
ENSMUST00000070810.8 Npy5r ENSMUST00000070810.8 neuropeptide Y receptor Y5, transcript variant 1 (from RefSeq NM_016708.3) ENSMUST00000070810.1 ENSMUST00000070810.2 ENSMUST00000070810.3 ENSMUST00000070810.4 ENSMUST00000070810.5 ENSMUST00000070810.6 ENSMUST00000070810.7 NM_016708 Npy5r Q543U8 Q543U8_MOUSE uc009lvr.1 uc009lvr.2 uc009lvr.3 Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein peptide YY receptor activity pancreatic polypeptide receptor activity positive regulation of acute inflammatory response negative regulation of acute inflammatory response to antigenic stimulus outflow tract morphogenesis cardiac left ventricle morphogenesis G-protein coupled receptor activity neuropeptide Y receptor activity cytoplasm G-protein coupled receptor signaling pathway neuropeptide signaling pathway aging positive regulation of cell proliferation negative regulation of glutamate secretion membrane integral component of membrane negative regulation of synaptic transmission, GABAergic eating behavior negative regulation of apoptotic process positive regulation of smooth muscle cell proliferation generation of ovulation cycle rhythm positive regulation of ERK1 and ERK2 cascade uc009lvr.1 uc009lvr.2 uc009lvr.3 
ENSMUST00000070816.9 Artn ENSMUST00000070816.9 artemin, transcript variant 4 (from RefSeq NM_009711.4) ARTN_MOUSE ENSMUST00000070816.1 ENSMUST00000070816.2 ENSMUST00000070816.3 ENSMUST00000070816.4 ENSMUST00000070816.5 ENSMUST00000070816.6 ENSMUST00000070816.7 ENSMUST00000070816.8 NM_009711 Q3SXF4 Q3SXF5 Q9Z0L2 uc008ujh.1 uc008ujh.2 uc008ujh.3 uc008ujh.4 This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Mice lacking a functional copy of this gene exhibit ptosis and impaired development of the sympathetic nervous system. [provided by RefSeq, Aug 2016]. Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain (By similarity). Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Homodimer; disulfide-linked (By similarity). Binds to RET. Secreted Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Z0L2-1; Sequence=Displayed; Name=2; IsoId=Q9Z0L2-2; Sequence=VSP_019338, VSP_019340; Name=3; IsoId=Q9Z0L2-3; Sequence=VSP_019337, VSP_019339, VSP_019340; Belongs to the TGF-beta family. GDNF subfamily. receptor binding protein binding extracellular region extracellular space cell surface receptor signaling pathway axon guidance peripheral nervous system development growth factor activity glial cell-derived neurotrophic factor receptor binding induction of positive chemotaxis Peyer's patch morphogenesis lymphocyte migration into lymphoid organs uc008ujh.1 uc008ujh.2 uc008ujh.3 uc008ujh.4 
ENSMUST00000070820.7 Dcst1 ENSMUST00000070820.7 DC-STAMP domain containing 1 (from RefSeq NM_029974.2) DCST1_MOUSE ENSMUST00000070820.1 ENSMUST00000070820.2 ENSMUST00000070820.3 ENSMUST00000070820.4 ENSMUST00000070820.5 ENSMUST00000070820.6 NM_029974 Q059Y8 uc008pyy.1 uc008pyy.2 uc008pyy.3 This gene encodes a transmembrane protein. A similar gene in human has been associated with dendritic cells. [provided by RefSeq, May 2015]. ##Evidence-Data-START## Transcript exon combination :: AK030269.1, BC125478.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteasomal degradation thereby negatively regulating type-I-interferon signaling. Essential sperm cell-surface protein required for sperm-egg fusion and fertilization. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with STAT2; the interaction results in STAT2 'Lys- 48'-linked ubiquitination leading to its proteasomal degradation. Interacts with DCST2 (PubMed:35393517). Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Multi-pass membrane protein Note=Localizes in the anterior acrosome before the acrosome reaction and then translocates to the equatorial segment in acrosome-reacted sperm. Expressed in testis. In testis, not detected before 3 weeks after birth. The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity. Knockout males are sterile despite normal mating behavior with ejaculation and vaginal plug formation (PubMed:33871360, PubMed:35393517). DCST1 and DCST2 double knockout males, but not females, are completely infertile. Mutants have no disturbances in sperm migration into the oviduct, acrosome reaction and zona penetration. Mutant spermatozoa are capable of binding to the plasma membranes of oocytes but fail to proceed to membrane fusion with oocytes (PubMed:33871360, PubMed:35393517). immune system process plasma membrane ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination transferase activity innate immune response metal ion binding negative regulation of type I interferon-mediated signaling pathway ubiquitin protein ligase activity uc008pyy.1 uc008pyy.2 uc008pyy.3 
ENSMUST00000070832.3 Wfdc21 ENSMUST00000070832.3 WAP four-disulfide core domain 21 (from RefSeq NM_183249.2) ENSMUST00000070832.1 ENSMUST00000070832.2 NM_183249 Q8BTE6 WFD21_MOUSE Wdnml1 Wfdc21 uc007kps.1 uc007kps.2 uc007kps.3 May promote activation of the metalloproteinase MMP2. Secreted Predominantly expressed in white adipose tissue and liver. Up-regulated by TNF-alpha and lipopolysaccharide (LPS) in vitro. extracellular region extracellular space enzyme activator activity negative regulation of peptidase activity peptidase inhibitor activity response to lipopolysaccharide response to tumor necrosis factor positive regulation of catalytic activity white fat cell differentiation uc007kps.1 uc007kps.2 uc007kps.3 
ENSMUST00000070850.8 Ppp1r14b ENSMUST00000070850.8 protein phosphatase 1, regulatory inhibitor subunit 14B (from RefSeq NM_008889.2) ENSMUST00000070850.1 ENSMUST00000070850.2 ENSMUST00000070850.3 ENSMUST00000070850.4 ENSMUST00000070850.5 ENSMUST00000070850.6 ENSMUST00000070850.7 NM_008889 PP14B_MOUSE Png Q62084 Q640Q7 uc008gjs.1 uc008gjs.2 uc008gjs.3 Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated. Cytoplasm Ubiquitous. Highly expressed in testis. Detected at low levels in the other tissues tested. Highly expressed in cardiac muscle, bladder and aorta (at protein level). Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro). Belongs to the PP1 inhibitor family. Sequence=CAA66121.1; Type=Erroneous initiation; Evidence=; protein phosphatase inhibitor activity protein serine/threonine phosphatase inhibitor activity cytoplasm phosphatase inhibitor activity protein phosphatase regulator activity negative regulation of phosphoprotein phosphatase activity regulation of phosphorylation negative regulation of catalytic activity regulation of phosphoprotein phosphatase activity innate immune response uc008gjs.1 uc008gjs.2 uc008gjs.3 
ENSMUST00000070872.13 Slc16a6 ENSMUST00000070872.13 solute carrier family 16 (monocarboxylic acid transporters), member 6, transcript variant 2 (from RefSeq NM_134038.4) B1AT66 D3Z3P6 E9Q5J8 ENSMUST00000070872.1 ENSMUST00000070872.10 ENSMUST00000070872.11 ENSMUST00000070872.12 ENSMUST00000070872.2 ENSMUST00000070872.3 ENSMUST00000070872.4 ENSMUST00000070872.5 ENSMUST00000070872.6 ENSMUST00000070872.7 ENSMUST00000070872.8 ENSMUST00000070872.9 MOT7_MOUSE Mct7 NM_134038 Q3TCY8 Q8C086 Q91W47 Slc16a6 uc007mcl.1 uc007mcl.2 uc007mcl.3 uc007mcl.4 Monocarboxylate transporter selective for taurine. May associate with BSG/CD147 or EMB/GP70 ancillary proteins to mediate facilitative efflux or influx of taurine across the plasma membrane. The transport is pH- and sodium-independent. Rather low-affinity, is likely effective for taurine transport in tissues where taurine is present at high concentrations. Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328, ChEBI:CHEBI:507393; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66329; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:66330; Evidence=; Forms functional complexes with BSG/CD147 or EMB/GP70 ancillary proteins. Basolateral cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B1AT66-1; Sequence=Displayed; Name=2; IsoId=B1AT66-2; Sequence=VSP_042512; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. plasma membrane integral component of plasma membrane monocarboxylic acid transmembrane transporter activity symporter activity monocarboxylic acid transport membrane integral component of membrane transmembrane transport uc007mcl.1 uc007mcl.2 uc007mcl.3 uc007mcl.4 
ENSMUST00000070875.8 Ankrd33 ENSMUST00000070875.8 ankyrin repeat domain 33, transcript variant 1 (from RefSeq NM_144790.1) Ankrd33 D5G1T0 ENSMUST00000070875.1 ENSMUST00000070875.2 ENSMUST00000070875.3 ENSMUST00000070875.4 ENSMUST00000070875.5 ENSMUST00000070875.6 ENSMUST00000070875.7 NM_144790 PANKY_MOUSE Panky Q8BXP4 Q8BXP5 Q8R1Z1 uc007xsk.1 uc007xsk.2 uc007xsk.3 uc007xsk.4 [Isoform 1]: Acts as a transcriptional repressor for CRX- activated photoreceptor gene regulation. [Isoform 1]: Cytoplasm, cytosol Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Panky-A ; IsoId=Q8BXP5-1; Sequence=Displayed; Name=2; Synonyms=Panky-B ; IsoId=Q8BXP5-2; Sequence=VSP_059268; Isoform 1: Expressed predominantly in the retina. Isoform 2: Expressed in the pineal gland. [Isoform 1]: Predominantly expressed in developing and mature photoreceptors (at protein level). [Isoform 1]: Expression is up-regulated by the CRX transcription factor. Sequence=BAC31971.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence=; negative regulation of transcription from RNA polymerase II promoter molecular_function nucleus cytoplasm cytosol skeletal muscle cell differentiation negative regulation of transcription regulatory region DNA binding uc007xsk.1 uc007xsk.2 uc007xsk.3 uc007xsk.4 
ENSMUST00000070877.7 Amacr ENSMUST00000070877.7 alpha-methylacyl-CoA racemase, transcript variant 2 (from RefSeq NR_177236.1) AMACR_MOUSE ENSMUST00000070877.1 ENSMUST00000070877.2 ENSMUST00000070877.3 ENSMUST00000070877.4 ENSMUST00000070877.5 ENSMUST00000070877.6 Macr1 NR_177236 O09174 Q543Q9 Q9DCW6 uc007vgw.1 uc007vgw.2 uc007vgw.3 Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (By similarity). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3- methyl-branched nor linear-chain acyl-CoAs (By similarity). Reaction=a (2S)-2-methylacyl-CoA = a (2R)-2-methylacyl-CoA; Xref=Rhea:RHEA:12657, ChEBI:CHEBI:57313, ChEBI:CHEBI:57314; EC=5.1.99.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12658; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:12659; Evidence=; Reaction=(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl- CoA = (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl- CoA; Xref=Rhea:RHEA:40455, ChEBI:CHEBI:58677, ChEBI:CHEBI:77251; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40456; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:40457; Evidence=; Reaction=(2R,6)-dimethylheptanoyl-CoA = (2S,6)-dimethylheptanoyl-CoA; Xref=Rhea:RHEA:46732, ChEBI:CHEBI:86982, ChEBI:CHEBI:86983; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46733; Evidence=; Lipid metabolism; bile acid biosynthesis. Lipid metabolism; fatty acid metabolism. Monomer. Peroxisome Mitochondrion Belongs to the CoA-transferase III family. Sequence=AAB72146.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; receptor binding cytoplasm mitochondrion peroxisome plasma membrane fatty acid metabolic process bile acid biosynthetic process alpha-methylacyl-CoA racemase activity bile acid metabolic process isoprenoid catabolic process CoA-transferase activity isomerase activity intracellular membrane-bounded organelle uc007vgw.1 uc007vgw.2 uc007vgw.3 
ENSMUST00000070890.6 Chst13 ENSMUST00000070890.6 carbohydrate sulfotransferase 13 (from RefSeq NM_027928.1) Chst13 D3Z6E3 D3Z6E3_MOUSE ENSMUST00000070890.1 ENSMUST00000070890.2 ENSMUST00000070890.3 ENSMUST00000070890.4 ENSMUST00000070890.5 NM_027928 uc012eov.1 uc012eov.2 uc012eov.3 Golgi apparatus membrane ; Single- pass type II membrane protein mbrane ; Single-pass type II membrane protein Belongs to the sulfotransferase 2 family. Golgi membrane N-acetylgalactosamine 4-O-sulfotransferase activity cellular_component Golgi apparatus carbohydrate metabolic process sulfotransferase activity integral component of membrane carbohydrate biosynthetic process transferase activity proteoglycan biosynthetic process chondroitin sulfate biosynthetic process chondroitin 4-sulfotransferase activity uc012eov.1 uc012eov.2 uc012eov.3 
ENSMUST00000070892.8 Dsg3 ENSMUST00000070892.8 desmoglein 3 (from RefSeq NM_030596.4) Dsg3 ENSMUST00000070892.1 ENSMUST00000070892.2 ENSMUST00000070892.3 ENSMUST00000070892.4 ENSMUST00000070892.5 ENSMUST00000070892.6 ENSMUST00000070892.7 NM_030596 Q3UFC6 Q3UFC6_MOUSE uc008eep.1 uc008eep.2 uc008eep.3 uc008eep.4 This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein exhibit loss of keratinocyte cell adhesion resulting in a phenotype that resembles that of patients with pemphigus vulgaris. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK148657.1, AK037142.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell junction, desmosome Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eep.1 uc008eep.2 uc008eep.3 uc008eep.4 
ENSMUST00000070911.4 Apol8 ENSMUST00000070911.4 apolipoprotein L 8, transcript variant 2 (from RefSeq NM_001357895.1) A2VDH7 A2VDH7_MOUSE Apol8 ENSMUST00000070911.1 ENSMUST00000070911.2 ENSMUST00000070911.3 F6VS49 F7B5U4 NM_001357895 uc007wob.1 uc007wob.2 uc007wob.3 uc007wob.4 Belongs to the apolipoprotein L family. extracellular region lipid transport biological_process lipid binding membrane integral component of membrane lipoprotein metabolic process uc007wob.1 uc007wob.2 uc007wob.3 uc007wob.4 
ENSMUST00000070918.14 Cmbl ENSMUST00000070918.14 carboxymethylenebutenolidase homolog (from RefSeq NM_181588.4) CMBL_MOUSE ENSMUST00000070918.1 ENSMUST00000070918.10 ENSMUST00000070918.11 ENSMUST00000070918.12 ENSMUST00000070918.13 ENSMUST00000070918.2 ENSMUST00000070918.3 ENSMUST00000070918.4 ENSMUST00000070918.5 ENSMUST00000070918.6 ENSMUST00000070918.7 ENSMUST00000070918.8 ENSMUST00000070918.9 NM_181588 Q8C1N1 Q8R1G2 uc007vki.1 uc007vki.2 uc007vki.3 Cysteine hydrolase. Cytoplasm, cytosol Belongs to the dienelactone hydrolase family. Sequence=BAC25255.1; Type=Frameshift; Evidence=; molecular_function cytoplasm cytosol biological_process hydrolase activity uc007vki.1 uc007vki.2 uc007vki.3 
ENSMUST00000070923.3 Them6 ENSMUST00000070923.3 thioesterase superfamily member 6 (from RefSeq NM_198607.1) ENSMUST00000070923.1 ENSMUST00000070923.2 NM_198607 Q80ZW2 THEM6_MOUSE uc007wfs.1 uc007wfs.2 uc007wfs.3 Secreted Belongs to the THEM6 family. molecular_function cellular_component extracellular region biological_process uc007wfs.1 uc007wfs.2 uc007wfs.3 
ENSMUST00000070942.3 A530095I07Rik ENSMUST00000070942.3 A530095I07Rik (from geneSymbol) AK041266 ENSMUST00000070942.1 ENSMUST00000070942.2 uc007rcj.1 uc007rcj.2 uc007rcj.3 uc007rcj.4 uc007rcj.1 uc007rcj.2 uc007rcj.3 uc007rcj.4 
ENSMUST00000070951.8 Plpp1 ENSMUST00000070951.8 phospholipid phosphatase 1, transcript variant 2 (from RefSeq NM_008903.2) ENSMUST00000070951.1 ENSMUST00000070951.2 ENSMUST00000070951.3 ENSMUST00000070951.4 ENSMUST00000070951.5 ENSMUST00000070951.6 ENSMUST00000070951.7 Hpic53 Lpp1 NM_008903 PLPP1_MOUSE Plpp1 Ppap2a Q61469 Q61690 Q6GT30 Q8BPB8 uc007rwq.1 uc007rwq.2 uc007rwq.3 uc007rwq.4 Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P (PubMed:8702556, PubMed:10359651, PubMed:10818444, PubMed:10620492, PubMed:15461590, PubMed:19215222). Also acts on N- oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:17379599). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:15461590, PubMed:17057224). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (PubMed:17057224). Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn- glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27430; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2- dihexadecanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:43236, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:72859, ChEBI:CHEBI:82929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43237; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2- di-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:43244, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43245; Evidence=; Reaction=H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate; Xref=Rhea:RHEA:46736, ChEBI:CHEBI:15377, ChEBI:CHEBI:17408, ChEBI:CHEBI:43474, ChEBI:CHEBI:77589; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46737; Evidence=; Reaction=(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z- octadecenoyl)-glycerol + phosphate; Xref=Rhea:RHEA:50884, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:75937, ChEBI:CHEBI:84973; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50885; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:33155, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57970, ChEBI:CHEBI:64683; EC=3.1.3.106; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33156; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z- octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:39835, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:74544, ChEBI:CHEBI:75757; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39836; Evidence=; Reaction=a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl- sn-glycero-3-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:27449, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608, ChEBI:CHEBI:59996; EC=3.6.1.75; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27450; Evidence=; Reaction=H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine; Xref=Rhea:RHEA:27518, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27519; Evidence=; Reaction=an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4- enine + phosphate; Xref=Rhea:RHEA:33743, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52639, ChEBI:CHEBI:57674; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33744; Evidence=; Reaction=H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N- octanoylsphing-4-enine + phosphate; Xref=Rhea:RHEA:62040, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:45815, ChEBI:CHEBI:85376; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62041; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z- octadecenoyl) ethanolamine + phosphate; Xref=Rhea:RHEA:62160, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:71466, ChEBI:CHEBI:145465; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62161; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:41255, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:64839, ChEBI:CHEBI:75466; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41256; Evidence=; Magnesium-independent phospholipid phosphatase. Insensitive to N-ethylmaleimide. Kinetic parameters: KM=67 uM for 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate ; Vmax=1.25 nmol/min/mg enzyme with 1,2-di-(9Z-octadecenoyl)-sn- glycero-3-phosphate as substrate ; Lipid metabolism; phospholipid metabolism. Forms functional homodimers and homooligomers that are not required for substrate recognition and catalytic activity (PubMed:14725715). Can also form heterooligomers with PLPP2 and PLPP3 (By similarity). Cell membrane ulti-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Membrane raft ; Multi-pass membrane protein Membrane, caveola ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61469-1; Sequence=Displayed; Name=2; IsoId=Q61469-2; Sequence=VSP_009652; Widely expressed (PubMed:19215222). Highly expressed in kidney and lung. Almost undetectable in brain, heart, bone, muscle or spleen. Moderately, by hydrogen peroxide, calcium ionophore and dexamethasone. N-glycosylated (PubMed:8702556, PubMed:10620492). N-linked sugars are of the complex type (PubMed:8702556). N-glycosylation is not required for the phosphatase activity (PubMed:10620492). Overexpression elicited a number of phenotypic alteration without affecting several aspects of LPA signaling. Phenotypic abnormalities affect primarily three organs: the liver, the skin, and the reproductive organs. There is a reduction on body size, birth weight, abnormalities in fur growth, and a severely impaired spermatogenesis. Belongs to the PA-phosphatase related phosphoesterase family. Sequence=AAA85353.1; Type=Frameshift; Evidence=; plasma membrane integral component of plasma membrane protein dephosphorylation lipid metabolic process phospholipid metabolic process diacylglycerol biosynthetic process sphingosine metabolic process ceramide metabolic process signal transduction phosphatidate phosphatase activity membrane integral component of membrane hydrolase activity phosphatase activity lipid phosphatase activity phospholipid dephosphorylation uc007rwq.1 uc007rwq.2 uc007rwq.3 uc007rwq.4 
ENSMUST00000070968.14 Stat1 ENSMUST00000070968.14 signal transducer and activator of transcription 1, transcript variant 2 (from RefSeq NM_009283.4) E9QK78 ENSMUST00000070968.1 ENSMUST00000070968.10 ENSMUST00000070968.11 ENSMUST00000070968.12 ENSMUST00000070968.13 ENSMUST00000070968.2 ENSMUST00000070968.3 ENSMUST00000070968.4 ENSMUST00000070968.5 ENSMUST00000070968.6 ENSMUST00000070968.7 ENSMUST00000070968.8 ENSMUST00000070968.9 NM_009283 Q8C3V4 Q8C3V4_MOUSE Stat1 uc007aya.1 uc007aya.2 uc007aya.3 uc007aya.4 Cytoplasm cleus Belongs to the transcription factor STAT family. DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated signal transduction uc007aya.1 uc007aya.2 uc007aya.3 uc007aya.4 
ENSMUST00000070980.4 4933402N03Rik ENSMUST00000070980.4 RIKEN cDNA 4933402N03 gene (from RefSeq NM_173409.4) CJ120_MOUSE ENSMUST00000070980.1 ENSMUST00000070980.2 ENSMUST00000070980.3 NM_173409 Q8CDT9 uc009kay.1 uc009kay.2 uc009kay.3 Dispensable for normal development and fertility. Expressed in testis and epididymis (PubMed:36871790). Expressed at lower levels in ovary (PubMed:36871790). No visible phenotype (PubMed:36871790). No effect on testis size, testis-to-body weight ratio, germ cell development or spermiogenesis (PubMed:36871790). No effect on sperm morphology, count or motility (PubMed:36871790). No effect on levels of germ cell apoptosis, chromosome H1t histone association or acrosome biogenesis (PubMed:36871790). molecular_function biological_process uc009kay.1 uc009kay.2 uc009kay.3 
ENSMUST00000070987.9 Gm5533 ENSMUST00000070987.9 Gm5533 (from geneSymbol) AK040286 ENSMUST00000070987.1 ENSMUST00000070987.2 ENSMUST00000070987.3 ENSMUST00000070987.4 ENSMUST00000070987.5 ENSMUST00000070987.6 ENSMUST00000070987.7 ENSMUST00000070987.8 uc287ood.1 uc287ood.2 uc287ood.3 uc287ood.1 uc287ood.2 uc287ood.3 
ENSMUST00000070991.5 Tas2r129 ENSMUST00000070991.5 taste receptor, type 2, member 129 (from RefSeq NM_207029.1) ENSMUST00000070991.1 ENSMUST00000070991.2 ENSMUST00000070991.3 ENSMUST00000070991.4 NM_207029 Q7M709 T2r60 TR129_MOUSE Tas2r129 uc009ejv.1 uc009ejv.2 uc009ejv.3 Putative taste receptor which may play a role in the perception of bitterness. Membrane ; Multi-pass membrane protein Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009ejv.1 uc009ejv.2 uc009ejv.3 
ENSMUST00000071016.3 Gm13199 ENSMUST00000071016.3 Gm13199 (from geneSymbol) AK047370 ENSMUST00000071016.1 ENSMUST00000071016.2 Gm13199 OTTMUSG00000010878 Q8C8E0 Q8C8E0_MOUSE uc008ifw.1 uc008ifw.2 uc008ifw.3 uc008ifw.4 uc008ifw.5 uc008ifw.6 molecular_function cellular_component biological_process uc008ifw.1 uc008ifw.2 uc008ifw.3 uc008ifw.4 uc008ifw.5 uc008ifw.6 
ENSMUST00000071023.12 Pabir2 ENSMUST00000071023.12 PABIR family member 2, transcript variant 2 (from RefSeq NM_030167.4) B1B0Y4 B1B0Y5 ENSMUST00000071023.1 ENSMUST00000071023.10 ENSMUST00000071023.11 ENSMUST00000071023.2 ENSMUST00000071023.3 ENSMUST00000071023.4 ENSMUST00000071023.5 ENSMUST00000071023.6 ENSMUST00000071023.7 ENSMUST00000071023.8 ENSMUST00000071023.9 Fam122b NM_030167 PBIR2_MOUSE Pabir2 Q6NZE7 Q8BRG5 Q8CBB0 Q9D2N2 uc009tev.1 uc009tev.2 uc009tev.3 Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6NZE7-1; Sequence=Displayed; Name=2; IsoId=Q6NZE7-2; Sequence=VSP_021219; Name=3; IsoId=Q6NZE7-3; Sequence=VSP_021220; Name=4; IsoId=Q6NZE7-4; Sequence=VSP_021221; Belongs to the FAM122 family. molecular_function cellular_component biological_process uc009tev.1 uc009tev.2 uc009tev.3 
ENSMUST00000071026.10 Eif5a ENSMUST00000071026.10 eukaryotic translation initiation factor 5A, transcript variant 6 (from RefSeq NM_001166593.1) ENSMUST00000071026.1 ENSMUST00000071026.2 ENSMUST00000071026.3 ENSMUST00000071026.4 ENSMUST00000071026.5 ENSMUST00000071026.6 ENSMUST00000071026.7 ENSMUST00000071026.8 ENSMUST00000071026.9 IF5A1_MOUSE NM_001166593 P10159 P63242 Q16182 Q5NCX0 Q78NR3 Q9D0G2 uc011xxk.1 uc011xxk.2 uc011xxk.3 This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]. Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (By similarity). Regulates also TNF-alpha-mediated apoptosis (By similarity). Mediates effects of polyamines on neuronal process extension and survival (PubMed:15377278). Binds to 80S ribosomes. Actively translating ribosomes show mutually exclusive binding of eIF5a (EIF5A or EIF5A2) and EEF2/eEF2 (By similarity). Interacts with DAPL1; interaction takes place at the polypeptide exit tunnel of hibernating ribosomes and prevents translation (By similarity). Interacts with DHPS. Interacts with SDCBP. Interacts with DOHH (By similarity). Cytoplasm Nucleus Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. Nuclear export of hypusinated protein is mediated by XPO4. Acetylated by PCAF/KAT2B, regulating its subcellular localization (By similarity). Deacetylated by SIRT2 (By similarity). Lys-50 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain, leading to the formation of the unusual amino acid hypusine. eIF-5As are the only known proteins to undergo this modification, which is essential for their function. Belongs to the eIF-5A family. Sequence=CAI35154.1; Type=Erroneous gene model prediction; Evidence=; RNA binding translation elongation factor activity nucleus annulate lamellae nuclear pore cytoplasm endoplasmic reticulum endoplasmic reticulum membrane mRNA export from nucleus translation translational elongation translational frameshifting protein export from nucleus apoptotic process positive regulation of cytosolic calcium ion concentration aging positive regulation of cell proliferation positive regulation of cardiac muscle cell apoptotic process protein transport membrane U6 snRNA binding dendrite ribosome binding neuronal cell body positive regulation of apoptotic process negative regulation of apoptotic process synapse positive regulation of translational elongation positive regulation of translational termination protein N-terminus binding mRNA transport positive regulation of muscle cell differentiation cellular response to thyroid hormone stimulus positive regulation of reactive oxygen species metabolic process uc011xxk.1 uc011xxk.2 uc011xxk.3 
ENSMUST00000071044.13 Capg ENSMUST00000071044.13 capping actin protein, gelsolin like, transcript variant 1 (from RefSeq NM_007599.4) Capg ENSMUST00000071044.1 ENSMUST00000071044.10 ENSMUST00000071044.11 ENSMUST00000071044.12 ENSMUST00000071044.2 ENSMUST00000071044.3 ENSMUST00000071044.4 ENSMUST00000071044.5 ENSMUST00000071044.6 ENSMUST00000071044.7 ENSMUST00000071044.8 ENSMUST00000071044.9 NM_007599 Q99LB4 Q99LB4_MOUSE uc009cis.1 uc009cis.2 uc009cis.3 nucleus nucleoplasm nucleolus cytoplasm centriole protein domain specific binding macromolecular complex binding actin filament binding barbed-end actin filament capping mitotic spindle Flemming body uc009cis.1 uc009cis.2 uc009cis.3 
ENSMUST00000071056.14 Bckdk ENSMUST00000071056.14 branched chain ketoacid dehydrogenase kinase (from RefSeq NM_009739.3) Bckdk ENSMUST00000071056.1 ENSMUST00000071056.10 ENSMUST00000071056.11 ENSMUST00000071056.12 ENSMUST00000071056.13 ENSMUST00000071056.2 ENSMUST00000071056.3 ENSMUST00000071056.4 ENSMUST00000071056.5 ENSMUST00000071056.6 ENSMUST00000071056.7 ENSMUST00000071056.8 ENSMUST00000071056.9 NM_009739 Q3UCB5 Q3UCB5_MOUSE uc009jxf.1 uc009jxf.2 uc009jxf.3 Mitochondrion matrix Belongs to the PDK/BCKDK protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding mitochondrion mitochondrial matrix mitochondrial alpha-ketoglutarate dehydrogenase complex protein phosphorylation branched-chain amino acid catabolic process kinase activity phosphorylation transferase activity transferase activity, transferring phosphorus-containing groups [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity uc009jxf.1 uc009jxf.2 uc009jxf.3 
ENSMUST00000071057.14 Ddx55 ENSMUST00000071057.14 DEAD box helicase 55, transcript variant 1 (from RefSeq NM_026409.4) DDX55_MOUSE ENSMUST00000071057.1 ENSMUST00000071057.10 ENSMUST00000071057.11 ENSMUST00000071057.12 ENSMUST00000071057.13 ENSMUST00000071057.2 ENSMUST00000071057.3 ENSMUST00000071057.4 ENSMUST00000071057.5 ENSMUST00000071057.6 ENSMUST00000071057.7 ENSMUST00000071057.8 ENSMUST00000071057.9 Kiaa1595 NM_026409 Q149H5 Q3U460 Q6ZPL9 Q8BZR1 uc008zqc.1 uc008zqc.2 uc008zqc.3 Probable ATP-binding RNA helicase. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily. Sequence=BAC98212.1; Type=Erroneous initiation; Evidence=; Sequence=BAE32574.1; Type=Erroneous initiation; Evidence=; nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus nucleolus cytosol hydrolase activity uc008zqc.1 uc008zqc.2 uc008zqc.3 
ENSMUST00000071064.13 Insig2 ENSMUST00000071064.13 insulin induced gene 2, transcript variant 2 (from RefSeq NM_178082.3) ENSMUST00000071064.1 ENSMUST00000071064.10 ENSMUST00000071064.11 ENSMUST00000071064.12 ENSMUST00000071064.2 ENSMUST00000071064.3 ENSMUST00000071064.4 ENSMUST00000071064.5 ENSMUST00000071064.6 ENSMUST00000071064.7 ENSMUST00000071064.8 ENSMUST00000071064.9 INSI2_MOUSE Insig2 NM_178082 Q3TMY2 Q8BWP1 Q91WG1 uc007cjq.1 uc007cjq.2 uc007cjq.3 uc007cjq.4 Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:12624180, PubMed:16100574). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:16100574). Binds oxysterol, including 22- hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (By similarity). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (By similarity). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139 (By similarity). Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); association is mediated via its interaction with SCAP and only takes place in the presence of sterols. Interacts with RNF139. Interacts with RNF145. Endoplasmic reticulum membrane ; Multi-pass membrane protein Expressed in liver, testis, kidney, spleen, intestine, brain and adrenal gland. Up-regulated in differentiating preadipocytes. Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4. The KxHxx motif mediates association with the coatomer complex. Phosphorylation at Ser-151 by PCK1 reduces binding to oxysterol, disrupting the interaction between INSIG2 and SCAP, thereby promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis- related genes. Polyubiquitinated by AMFR/gp78 at Cys-215 in some tissues such as adipose tissues, undifferentiated myoblasts and liver, leading to its degradation. In differentiated myotubes, Cys-215 oxidation prevents ubiquitination at the same site, resulting in protein stabilization. Oxidized at Cys-215 in differentiated myotubes, preventing ubiquitination at the same site, and resulting in protein stabilization. Knockout mice with a conditional deletion of Insig1 in the liver and a germline deletion of Insig2 overaccumulate cholesterol and triglycerides in liver: despite this accumulation, levels of nuclear sterol regulatory element-binding proteins (SREBPs) are not reduced (PubMed:16100574). The amount of HMGCR is also elevated, caused by impaired degradation of the enzyme (PubMed:16100574). Knockout mice with a germline deletion of both Insig1 and Insig2 die within one day of birth (PubMed:16100574, PubMed:16955138). After 18.5 days of development, embryos lacking both Insig1 and Insig2 show defects in midline facial development, ranging from cleft palate to complete cleft face: middle and inner ear structures are abnormal, but teeth and skeletons are normal (PubMed:16955138). The livers and heads of embryos lacking both Insig1 and Insig2 overproduce sterols, causing a marked buildup of sterol intermediates (PubMed:16955138). Belongs to the INSIG family. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process triglyceride metabolic process cholesterol biosynthetic process response to sterol depletion transcription factor binding steroid metabolic process cholesterol metabolic process negative regulation of steroid biosynthetic process membrane integral component of membrane sterol biosynthetic process response to insulin SREBP signaling pathway SREBP-SCAP-Insig complex response to lipid inner ear morphogenesis middle ear morphogenesis negative regulation of fatty acid biosynthetic process palate development cranial suture morphogenesis response to fatty acid uc007cjq.1 uc007cjq.2 uc007cjq.3 uc007cjq.4 
ENSMUST00000071065.8 Nfil3 ENSMUST00000071065.8 nuclear factor, interleukin 3, regulated (from RefSeq NM_017373.3) E4bp4 ENSMUST00000071065.1 ENSMUST00000071065.2 ENSMUST00000071065.3 ENSMUST00000071065.4 ENSMUST00000071065.5 ENSMUST00000071065.6 ENSMUST00000071065.7 NFIL3_MOUSE NM_017373 O08750 Q3ULK2 Q497U0 uc007qni.1 uc007qni.2 uc007qni.3 The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses Per1 and Per2 expression and therefore plays a role in the regulation of circadian rhythm. [provided by RefSeq, Feb 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC031377.1, AK087541.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites (By similarity). Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B- site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells (By similarity). Competes for the same consensus- binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death. Represses the transcription of CYP2A5 (PubMed:30555544). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (PubMed:29653076). Required for the development of natural killer cell precursors (PubMed:32190943). Homodimer (By similarity). Binds DNA as a dimer (By similarity). Interacts with DR1 (By similarity). Interacts with PER2 and CRY2 (PubMed:17274955). Interacts with NR0B2 (PubMed:30555544). Interacts with NR1D1 (PubMed:29653076). Interacts with MYSM1 (By similarity). Nucleus Expressed in suprachiasmatic nucleus and liver (at protein level). Expressed in suprachiasmatic nucleus, hippocampus, gyrus dentatus, piriform cortex, internal granular layer of olfactory bulb, dorsomedial hypothalamic nucleus, pontine nuclei, granular layer of cerebellum, liver and calvariae osteoblasts. Expressed in natural killer cell precursors in bone marrow (PubMed:32190943). Expression is regulated by circadian rhythms. Up-regulated by parathyroid hormone (PTH) (at protein level). Up-regulated by IL-3, forskolin, 8-bromo-cAMP, phorbol myristate acetate and PTH in primary osteoblasts and calvariae. Reduced number of natural killer cell-committed progenitors in bone marrow. Belongs to the bZIP family. NFIL3 subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter immune response circadian rhythm positive regulation of gene expression negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated rhythmic process cellular response to interleukin-4 uc007qni.1 uc007qni.2 uc007qni.3 
ENSMUST00000071067.4 C330011M18Rik ENSMUST00000071067.4 C330011M18Rik (from geneSymbol) AK049185 ENSMUST00000071067.1 ENSMUST00000071067.2 ENSMUST00000071067.3 uc292bmq.1 uc292bmq.2 uc292bmq.1 uc292bmq.2 
ENSMUST00000071077.14 Spata18 ENSMUST00000071077.14 spermatogenesis associated 18 (from RefSeq NM_178387.3) B7ZMP4 ENSMUST00000071077.1 ENSMUST00000071077.10 ENSMUST00000071077.11 ENSMUST00000071077.12 ENSMUST00000071077.13 ENSMUST00000071077.2 ENSMUST00000071077.3 ENSMUST00000071077.4 ENSMUST00000071077.5 ENSMUST00000071077.6 ENSMUST00000071077.7 ENSMUST00000071077.8 ENSMUST00000071077.9 MIEAP_MOUSE Mieap NM_178387 Q0P557 uc008xte.1 uc008xte.2 uc008xte.3 uc008xte.4 Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. May have a role in spermatogenesis, especially in cell differentiation from late elongate spermatids to mature spermatozoa (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Interacts (via coiled-coil domains) with BNIP3L (via BH3 domain). Interacts (via coiled-coil domains) with BNIP3 (via BH3 domain). Cytoplasm Mitochondrion outer membrane Note=Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha, Mieap-alpha; IsoId=Q0P557-1; Sequence=Displayed; Name=2; Synonyms=Beta, Mieap-beta; IsoId=Q0P557-2; Sequence=VSP_041057; Name=3; IsoId=Q0P557-3; Sequence=VSP_041058; In testis, expressed primarily in spermatids. By p53/TP53 and p63/TP63. Directly activated by p53/TP53. Belongs to the MIEAP family. molecular_function cytoplasm mitochondrion mitochondrial outer membrane cellular response to DNA damage stimulus multicellular organism development spermatogenesis membrane cell differentiation mitochondrial protein catabolic process mitophagy by induced vacuole formation sperm flagellum intracellular membrane-bounded organelle uc008xte.1 uc008xte.2 uc008xte.3 uc008xte.4 
ENSMUST00000071087.12 Cspp1 ENSMUST00000071087.12 centrosome and spindle pole associated protein 1, transcript variant 1 (from RefSeq NM_026493.3) B2RX88 C7SBE3 C7SBE4 CSPP1_MOUSE Cspp ENSMUST00000071087.1 ENSMUST00000071087.10 ENSMUST00000071087.11 ENSMUST00000071087.2 ENSMUST00000071087.3 ENSMUST00000071087.4 ENSMUST00000071087.5 ENSMUST00000071087.6 ENSMUST00000071087.7 ENSMUST00000071087.8 ENSMUST00000071087.9 NM_026493 Q8CCQ4 Q8VE83 Q9CQD5 uc007ahi.1 uc007ahi.2 uc007ahi.3 May play a role in cell-cycle-dependent microtubule organization. Interacts with PLEKHG6. Interacts with ARMC9, TOGARAM1, CCDC66, CEP104 and CEP290 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=Associated with mitotic spindles. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=B2RX88-1; Sequence=Displayed; Name=2; Synonyms=Cspp2; IsoId=B2RX88-2; Sequence=VSP_040073, VSP_040079; Name=3; Synonyms=Cspp3; IsoId=B2RX88-3; Sequence=VSP_040074, VSP_040077, VSP_040078; Name=4; IsoId=B2RX88-4; Sequence=VSP_040074; Name=5; IsoId=B2RX88-5; Sequence=VSP_040075, VSP_040076; Name=6; IsoId=B2RX88-6; Sequence=VSP_040074, VSP_040075, VSP_040076; Phosphorylated. Phosphorylation increases in colcemide-treated cells (By similarity). spindle pole protein binding cytoplasm centrosome microtubule organizing center spindle cytoskeleton microtubule positive regulation of cytokinesis positive regulation of cell division uc007ahi.1 uc007ahi.2 uc007ahi.3 
ENSMUST00000071093.9 Rims3 ENSMUST00000071093.9 regulating synaptic membrane exocytosis 3 (from RefSeq NM_182929.3) ENSMUST00000071093.1 ENSMUST00000071093.2 ENSMUST00000071093.3 ENSMUST00000071093.4 ENSMUST00000071093.5 ENSMUST00000071093.6 ENSMUST00000071093.7 ENSMUST00000071093.8 Kiaa0237 NM_182929 Q80U57 RIMS3_MOUSE uc008unr.1 uc008unr.2 uc008unr.3 Regulates synaptic membrane exocytosis. Binds PPFIA3 (By similarity). Does not bind RAB3. Synapse neurotransmitter transport exocytosis membrane Rab GTPase binding calcium ion regulated exocytosis cell junction regulation of membrane potential presynaptic membrane ion channel binding synapse regulation of synaptic plasticity cytoskeleton of presynaptic active zone calcium ion-regulated exocytosis of neurotransmitter positive regulation of synaptic transmission regulation of synapse organization presynaptic active zone cytoplasmic component glutamatergic synapse postsynaptic cytosol regulation of synaptic vesicle exocytosis uc008unr.1 uc008unr.2 uc008unr.3 
ENSMUST00000071095.14 Setd3 ENSMUST00000071095.14 SET domain containing 3, transcript variant 2 (from RefSeq NM_028262.3) D12Ertd771e ENSMUST00000071095.1 ENSMUST00000071095.10 ENSMUST00000071095.11 ENSMUST00000071095.12 ENSMUST00000071095.13 ENSMUST00000071095.2 ENSMUST00000071095.3 ENSMUST00000071095.4 ENSMUST00000071095.5 ENSMUST00000071095.6 ENSMUST00000071095.7 ENSMUST00000071095.8 ENSMUST00000071095.9 NM_028262 Q6PEN3 Q8CD86 Q8CDX8 Q91WC0 Q9CZZ1 SETD3_MOUSE Setd3 uc007ozj.1 uc007ozj.2 uc007ozj.3 uc007ozj.4 Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30626964). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N- methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964). Reaction=L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:19369, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:11600, ChEBI:CHEBI:15378, ChEBI:CHEBI:16367, ChEBI:CHEBI:29979, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.85; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19370; Evidence=; Interacts with MYOD1. Cytoplasm Nucleus Note=Localizes mainly in the cytoplasm. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q91WC0-1; Sequence=Displayed; Name=2; IsoId=Q91WC0-2; Sequence=VSP_021195, VSP_021196; Name=3; IsoId=Q91WC0-3; Sequence=VSP_021194; Name=4; IsoId=Q91WC0-4; Sequence=VSP_021195, VSP_021197, VSP_021198; Prominently expressed in the heart and skeletal muscles and is also detected weakly in the stomach, small intestine, and colon. Expression is repressed by microRNAs miR-15b and miR-322, repressing muscle cell differentiation. The SET domain specifically recognizes and binds actin, suggesting that it does not accommodate substrates diverging from actin. Phosphorylated by GSK3B, which is required for recognition by the SCF(FBXW7) complex and subsequent degradation. Ubiquitinated by the SCF(FBXW7) complex following phosphorylation by GSK3B, leading to its degradation by the proteasome. Mice are viable, but females display severely decreased litter sizes due to primary maternal dystocia (delayed parturition) that is refractory to ecbolic induction agents (PubMed:30626964). Cells show complete loss of actin histidine methylation (PubMed:30626964). Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family. Was initially reported to have histone methyltransferase activity and methylate 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me) (PubMed:21832073). However, this conclusion was based on mass spectrometry data wherin mass shifts were inconsistent with a bona fide methylation event and the histone methyltransferase activity could not be confirmed (PubMed:30626964). nuclear chromatin RNA polymerase II activating transcription factor binding transcription coactivator activity actin binding nucleus cytoplasm methyltransferase activity histone H3-K36 methylation protein-lysine N-methyltransferase activity transferase activity peptidyl-histidine methylation peptidyl-lysine trimethylation peptidyl-lysine monomethylation peptidyl-lysine dimethylation protein-histidine N-methyltransferase activity actin modification methylation histone methyltransferase activity (H3-K4 specific) positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter histone methyltransferase activity (H3-K36 specific) positive regulation of muscle cell differentiation histone H3-K4 methylation regulation of uterine smooth muscle contraction uc007ozj.1 uc007ozj.2 uc007ozj.3 uc007ozj.4 
ENSMUST00000071096.3 Hemgn ENSMUST00000071096.3 Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity). (from UniProt Q9ERZ0) AF269248 B1AVH8 ENSMUST00000071096.1 ENSMUST00000071096.2 HEMGN_MOUSE Ndr Q3TAE6 Q80YT2 Q8CF29 Q9ERZ0 uc008sts.1 uc008sts.2 uc008sts.3 Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity). Nucleus Expressed in hematopoietic precursor cells. Highly expressed in bone marrow, the red pulp of the spleen and round spermatids. Weakly expressed in peripheral blood cells. Expressed at 8.5 dpc in the blood islands of the yolk sac and in the circulating primitive blood cells. Expressed in the circulating blood cells at 9.5 dpc and 10.5 dpc. Detected in the developing hepatic primordia at 10.5 dpc. From 11.5 dpc to 14.5 dpc, exclusively expressed in the fetal liver. molecular_function nucleus nucleoplasm multicellular organism development cell differentiation regulation of osteoblast differentiation uc008sts.1 uc008sts.2 uc008sts.3 
ENSMUST00000071103.10 Ddx1 ENSMUST00000071103.10 DEAD box helicase 1 (from RefSeq NM_134040.1) DDX1_MOUSE ENSMUST00000071103.1 ENSMUST00000071103.2 ENSMUST00000071103.3 ENSMUST00000071103.4 ENSMUST00000071103.5 ENSMUST00000071103.6 ENSMUST00000071103.7 ENSMUST00000071103.8 ENSMUST00000071103.9 NM_134040 Q3TU41 Q91VR5 uc007nbh.1 uc007nbh.2 uc007nbh.3 Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double- strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation (By similarity). Acts as a positive transcriptional regulator of cyclin CCND2 expression (PubMed:19398953). Binds to the cyclin CCND2 promoter region (PubMed:19398953). Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (PubMed:21703541). Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (PubMed:21703541). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this complex exists in resting cells with or without poly(I:C) RNA ligand stimulation (PubMed:21703541). Interacts with DHX36 (PubMed:21703541). Interacts (via B30.2/SPRY domain) with DDX21 (via N-terminus); this interaction serves as bridges to TICAM1 (PubMed:21703541). Interacts with FAM98A (via N- and C- terminus) (By similarity). Interacts with MBNL1 (By similarity). Interacts with CSTF2 (By similarity). Interacts with HNRNPK (By similarity). Interacts with ATM (By similarity). Interacts with RELA (via C-terminus) (By similarity). Component of the tRNA-splicing ligase complex (By similarity). Interacts with PHF5A (via C-terminus) (PubMed:18758164). Interacts with PQBP1 (By similarity). Interacts with ERCC6 (By similarity). Nucleus Cytoplasm, cytosol Cytoplasm Cytoplasmic granule Mitochondrion Note=Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR-induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM-dependent manner after IR treatment. Colocalized with RELA in the nucleus upon TNF-alpha induction. Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (By similarity). Colocalizes in the cytosol with DDX21, DHX36 and TICAM1 (PubMed:21703541). Colocalizes in the mitochondria with TICAM1 and poly(I:C) RNA ligand (PubMed:21703541). The multi- helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) stimulation (PubMed:21703541). Testis-specific. Expressed in the germ line stem cells, spermatogonia and spermatocytes of the testis. Also expressed in the seminoma and nonseminoma types of testicular germ cell tumors (TGCTs) (at protein level). Expressed in the testis from 11.5 to 19.5 dpc. The helicase domain is involved in the stimulation of RELA transcriptional activity. Phosphorylated by ATM kinase; phosphorylation is increased in response to ionizing radiation (IR). Belongs to the DEAD box helicase family. DDX1 subfamily. nucleotide binding immune system process positive regulation of myeloid dendritic cell cytokine production nucleic acid binding DNA binding chromatin binding transcription cofactor activity RNA binding RNA helicase activity double-stranded RNA binding helicase activity nuclease activity exonuclease activity protein binding ATP binding nucleus nucleoplasm cytoplasm mitochondrion cytosol double-strand break repair tRNA splicing, via endonucleolytic cleavage and ligation mRNA processing multicellular organism development tRNA processing poly(A) binding response to virus cytoplasmic stress granule hydrolase activity DNA duplex unwinding DNA/RNA helicase activity positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA innate immune response defense response to virus cleavage body tRNA-splicing ligase complex nucleic acid phosphodiester bond hydrolysis regulation of nucleic acid-templated transcription protein localization to cytoplasmic stress granule ribonucleoprotein complex uc007nbh.1 uc007nbh.2 uc007nbh.3 
ENSMUST00000071104.6 Krt72 ENSMUST00000071104.6 keratin 72 (from RefSeq NM_213728.2) ENSMUST00000071104.1 ENSMUST00000071104.2 ENSMUST00000071104.3 ENSMUST00000071104.4 ENSMUST00000071104.5 K2C72_MOUSE Kb35 Krt72-ps NM_213728 Q6IME9 uc007xtz.1 uc007xtz.2 uc007xtz.3 Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity). Heterotetramer of two type I and two type II keratins. There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively). Belongs to the intermediate filament family. intermediate filament keratin filament uc007xtz.1 uc007xtz.2 uc007xtz.3 
ENSMUST00000071106.6 Gpatch2l ENSMUST00000071106.6 G patch domain containing 2 like, transcript variant 2 (from RefSeq NM_001324488.1) ENSMUST00000071106.1 ENSMUST00000071106.2 ENSMUST00000071106.3 ENSMUST00000071106.4 ENSMUST00000071106.5 GPT2L_MOUSE Kiaa1152 NM_001324488 Q6PE65 Q6ZPW9 Q8CD08 Q9DA49 uc007ohs.1 uc007ohs.2 uc007ohs.3 uc007ohs.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PE65-1; Sequence=Displayed; Name=2; IsoId=Q6PE65-2; Sequence=VSP_014717; Sequence=BAC98109.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process uc007ohs.1 uc007ohs.2 uc007ohs.3 uc007ohs.4 
ENSMUST00000071118.7 Prp2rt ENSMUST00000071118.7 May play a role in cell differentiation in the intestinal epithelium. (from UniProt Q9R1Q7) ENSMUST00000071118.1 ENSMUST00000071118.2 ENSMUST00000071118.3 ENSMUST00000071118.4 ENSMUST00000071118.5 ENSMUST00000071118.6 LF199676 PLP2_MOUSE Plp2 Q3U4I3 Q9R1Q7 uc288pis.1 uc288pis.2 May play a role in cell differentiation in the intestinal epithelium. Membrane ; Multi-pass membrane protein plasma membrane membrane integral component of membrane chemokine binding uc288pis.1 uc288pis.2 
ENSMUST00000071119.8 Tssk5 ENSMUST00000071119.8 testis-specific serine kinase 5 (from RefSeq NM_183099.2) ENSMUST00000071119.1 ENSMUST00000071119.2 ENSMUST00000071119.3 ENSMUST00000071119.4 ENSMUST00000071119.5 ENSMUST00000071119.6 ENSMUST00000071119.7 NM_183099 Q1WWK7 Q8C1R0 TSSK5_MOUSE Tssk5 uc007wka.1 uc007wka.2 uc007wka.3 May be involved in a signaling pathway during male germ cell development or mature sperm function. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation on Thr-207, potentially by autophosphorylation. Autophosphorylated. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Sequence=BAC25160.1; Type=Frameshift; Evidence=; nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation multicellular organism development spermatogenesis kinase activity phosphorylation transferase activity cell differentiation intracellular signal transduction metal ion binding uc007wka.1 uc007wka.2 uc007wka.3 
ENSMUST00000071130.5 Alox5ap ENSMUST00000071130.5 arachidonate 5-lipoxygenase activating protein, transcript variant 1 (from RefSeq NM_009663.2) AL5AP_MOUSE ENSMUST00000071130.1 ENSMUST00000071130.2 ENSMUST00000071130.3 ENSMUST00000071130.4 Flap NM_009663 P30355 Q9D138 uc009app.1 uc009app.2 uc009app.3 uc009app.4 Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity). Homotrimer. Interacts with LTC4S and ALOX5. Nucleus membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein The C-terminal part after residue 140 is mostly disordered. Belongs to the MAPEG family. leukotriene production involved in inflammatory response positive regulation of acute inflammatory response arachidonate 5-lipoxygenase activity glutathione transferase activity leukotriene-C4 synthase activity glutathione peroxidase activity protein binding nucleus nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane cytosol leukotriene metabolic process enzyme activator activity membrane integral component of membrane leukotriene biosynthetic process lipoxygenase pathway enzyme binding nuclear membrane protein homodimerization activity positive regulation of catalytic activity protein heterodimerization activity protein N-terminus binding arachidonic acid binding oxidation-reduction process protein homotrimerization cellular response to calcium ion cellular oxidant detoxification uc009app.1 uc009app.2 uc009app.3 uc009app.4 
ENSMUST00000071134.4 Tubb3 ENSMUST00000071134.4 tubulin, beta 3 class III (from RefSeq NM_023279.3) ENSMUST00000071134.1 ENSMUST00000071134.2 ENSMUST00000071134.3 NM_023279 Q3UF42 Q5I036 Q9ERD7 TBB3_MOUSE uc009nvt.1 uc009nvt.2 uc009nvt.3 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (By similarity). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (By similarity). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (By similarity). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (By similarity). Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with UNC5C (via cytoplasmic domain); this interaction is decreased by NTN1/Netrin-1 (PubMed:28483977). Interacts with NLRP5/MATER at cytoskeleton microtubules (By similarity). Interacts with DPYSL5 (By similarity). Q9ERD7; P47757: Capzb; NbExp=2; IntAct=EBI-2255594, EBI-299194; Q9ERD7; O08747: Unc5c; NbExp=3; IntAct=EBI-2255594, EBI-21004500; Cytoplasm, cytoskeleton Cell projection, growth cone Cell projection, lamellipodium Cell projection, filopodium Expressed in the external granular layer cells of the cerebellar cortex (at protein level). Detected at postnatal day 2 and 4. The highly acidic C-terminal region may bind cations such as calcium. The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation. Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility (PubMed:33414192). Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:15890843). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (PubMed:23897886). Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle GTPase activity structural constituent of cytoskeleton protein binding GTP binding cytoplasm cytoskeleton microtubule microtubule-based process axon guidance microtubule cytoskeleton lamellipodium filopodium neuron differentiation axon dendrite growth cone netrin-activated signaling pathway peptide binding cell projection neuronal cell body cell periphery dorsal root ganglion development netrin receptor binding uc009nvt.1 uc009nvt.2 uc009nvt.3 
ENSMUST00000071135.6 Tubb4a ENSMUST00000071135.6 tubulin, beta 4A class IVA (from RefSeq NM_009451.4) ENSMUST00000071135.1 ENSMUST00000071135.2 ENSMUST00000071135.3 ENSMUST00000071135.4 ENSMUST00000071135.5 NM_009451 Q62364 Q80Y54 Q9D6F9 TBB4A_MOUSE Tubb4 uc008dea.1 uc008dea.2 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Cytoplasm, cytoskeleton. The highly acidic C-terminal region may bind cations such as calcium. The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation. Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility (PubMed:33414192). Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:15890843). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (PubMed:23897886). Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle GTPase activity structural constituent of cytoskeleton calcium ion binding GTP binding cytoplasm cytoskeleton microtubule cilium axoneme microtubule-based process cell projection organization negative regulation of microtubule polymerization internode region of axon cell projection neuronal cell body myelin sheath uc008dea.1 uc008dea.2 
ENSMUST00000071149.7 Klrc3 ENSMUST00000071149.7 killer cell lectin-like receptor subfamily C, member 3 (from RefSeq NM_021378.1) ENSMUST00000071149.1 ENSMUST00000071149.2 ENSMUST00000071149.3 ENSMUST00000071149.4 ENSMUST00000071149.5 ENSMUST00000071149.6 Klrc3 NM_021378 Q9QXN7 Q9QXN7_MOUSE uc009egj.1 uc009egj.2 uc009egj.3 Cell membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein external side of plasma membrane membrane integral component of membrane carbohydrate binding uc009egj.1 uc009egj.2 uc009egj.3 
ENSMUST00000071169.9 Rcc2 ENSMUST00000071169.9 Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Functions as a guanine nucleotide exchange factor (GEF) for RALA. Interferes with the activation of RAC1 by guanine nucleotide exchange factors (By similarity). Prevents accumulation of active, GTP- bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (By similarity). (from UniProt Q8BK67) A2AWQ3 BC060624 ENSMUST00000071169.1 ENSMUST00000071169.2 ENSMUST00000071169.3 ENSMUST00000071169.4 ENSMUST00000071169.5 ENSMUST00000071169.6 ENSMUST00000071169.7 ENSMUST00000071169.8 Kiaa1470 Q6ZPQ0 Q8BK67 RCC2_MOUSE uc290rgh.1 uc290rgh.2 Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Functions as a guanine nucleotide exchange factor (GEF) for RALA. Interferes with the activation of RAC1 by guanine nucleotide exchange factors (By similarity). Prevents accumulation of active, GTP- bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (By similarity). Interacts with RAC1 (PubMed:25074804). Interacts with nucleotide-free and with GDP and GTP-bound forms of RAC1, with a slight preference for GDP-bound RAC1. Binds preferentially to the nucleotide- free form of RAC1. Interacts with CORO1C. Interacts with microtubules (By similarity). Nucleus, nucleolus Nucleus Cytoplasm, cytoskeleton Chromosome, centromere Cytoplasm, cytoskeleton, spindle Chromosome Midbody Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex. Colocalizes with cytoplasmic microtubules in interphase cells. Colocalizes with RAC1 at the cell membrane. Induced by TP53/p53 in response to oxidative stress and DNA damage. chromosome, centromeric region guanyl-nucleotide exchange factor activity nucleus chromosome nucleolus cytoplasm spindle cytoskeleton microtubule plasma membrane cell cycle integrin-mediated signaling pathway microtubule binding regulation of fibroblast migration positive regulation of G2/M transition of mitotic cell cycle membrane protein kinase binding protein domain specific binding regulation of cell migration midbody small GTPase binding early endosome membrane negative regulation of GTPase activity chromosome, centromeric core domain establishment of protein localization focal adhesion assembly Rac GTPase binding cell division negative regulation of focal adhesion assembly positive regulation of attachment of spindle microtubules to kinetochore chromosome passenger complex localization to kinetochore activation of GTPase activity negative regulation of substrate adhesion-dependent cell spreading regulation of ruffle assembly mitotic spindle midzone uc290rgh.1 uc290rgh.2 
ENSMUST00000071182.9 Pramel55 ENSMUST00000071182.9 PRAME like 55 (from RefSeq NM_001122668.1) ENSMUST00000071182.1 ENSMUST00000071182.2 ENSMUST00000071182.3 ENSMUST00000071182.4 ENSMUST00000071182.5 ENSMUST00000071182.6 ENSMUST00000071182.7 ENSMUST00000071182.8 NM_001122668 Pramel55 Pramel57 Q3UL33 Q3UL33_MOUSE uc008yfa.1 uc008yfa.2 uc008yfa.3 uc008yfa.4 uc008yfa.5 uc008yfa.6 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008yfa.1 uc008yfa.2 uc008yfa.3 uc008yfa.4 uc008yfa.5 uc008yfa.6 
ENSMUST00000071189.2 Fpr-rs3 ENSMUST00000071189.2 formyl peptide receptor, related sequence 3 (from RefSeq NM_008040.2) A4IF56 E9QL30 ENSMUST00000071189.1 FPRS3_MOUSE NM_008040 O88537 uc012alk.1 uc012alk.2 May have an olfactory function associated with the identification of pathogens or of pathogenic states. Cell membrane ; Multi-pass membrane protein Expressed exclusively in vomeronasal neurons (PubMed:19387439, PubMed:19497865). Expressed in 0.8 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Localized in sensory somata as well as dendritic cells. Each neuron appears to express only one receptor gene. Belongs to the G-protein coupled receptor 1 family. Name=Protein Spotlight; Note=A sickly smell - Issue 114 of February 2010; URL="https://web.expasy.org/spotlight/back_issues/114"; complement receptor mediated signaling pathway G-protein coupled receptor activity N-formyl peptide receptor activity plasma membrane chemotaxis inflammatory response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane uc012alk.1 uc012alk.2 
ENSMUST00000071199.9 Arl9 ENSMUST00000071199.9 Arl9 (from geneSymbol) Arl9 BC140255 ENSMUST00000071199.1 ENSMUST00000071199.2 ENSMUST00000071199.3 ENSMUST00000071199.4 ENSMUST00000071199.5 ENSMUST00000071199.6 ENSMUST00000071199.7 ENSMUST00000071199.8 Q6IMB2 Q6IMB2_MOUSE uc008xvr.1 uc008xvr.2 uc008xvr.3 nucleotide binding molecular_function GTP binding cellular_component biological_process uc008xvr.1 uc008xvr.2 uc008xvr.3 
ENSMUST00000071204.12 Ppef1 ENSMUST00000071204.12 protein phosphatase with EF hand calcium-binding domain 1 (from RefSeq NM_011147.1) A2AIC6 Dres10 ENSMUST00000071204.1 ENSMUST00000071204.10 ENSMUST00000071204.11 ENSMUST00000071204.2 ENSMUST00000071204.3 ENSMUST00000071204.4 ENSMUST00000071204.5 ENSMUST00000071204.6 ENSMUST00000071204.7 ENSMUST00000071204.8 ENSMUST00000071204.9 NM_011147 O35655 PPE1_MOUSE Ppef uc009uto.1 uc009uto.2 uc009uto.3 May have a role in the recovery or adaptation response of photoreceptors. May have a role in diverse sensory neurons and in development. Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by calcium. In the embryo it is almost exclusively expressed in the peripheral nervous system, within sensory neurons of cranial and dorsal root ganglia. Otherwise found in fetal inner ear and a small group of neurons in the midbrain/pons junction. Up-regulated at 12.3 dpc in dorsal root ganglia (DRG) and in some sensory cranial ganglia. A slightly decreased expression could still be detected in sensory ganglia at 16.5 dpc. It is not known if expression in sensory neurons persists in adult life. Belongs to the PPP phosphatase family. phosphoprotein phosphatase activity protein serine/threonine phosphatase activity iron ion binding calcium ion binding nucleus cytosol protein dephosphorylation hydrolase activity manganese ion binding metal ion binding detection of stimulus involved in sensory perception uc009uto.1 uc009uto.2 uc009uto.3 
ENSMUST00000071207.14 Fuz ENSMUST00000071207.14 fuzzy planar cell polarity protein, transcript variant 2 (from RefSeq NM_027376.4) E9QL29 E9QL29_MOUSE ENSMUST00000071207.1 ENSMUST00000071207.10 ENSMUST00000071207.11 ENSMUST00000071207.12 ENSMUST00000071207.13 ENSMUST00000071207.2 ENSMUST00000071207.3 ENSMUST00000071207.4 ENSMUST00000071207.5 ENSMUST00000071207.6 ENSMUST00000071207.7 ENSMUST00000071207.8 ENSMUST00000071207.9 Fuz NM_027376 uc009grt.1 uc009grt.2 uc009grt.3 Cytoplasm, cytoskeleton Belongs to the fuzzy family. neural tube closure negative regulation of cell migration positive regulation of cilium assembly non-motile cilium assembly uc009grt.1 uc009grt.2 uc009grt.3 
ENSMUST00000071215.5 Chchd1 ENSMUST00000071215.5 coiled-coil-helix-coiled-coil-helix domain containing 1 (from RefSeq NM_025366.3) CHCH1_MOUSE ENSMUST00000071215.1 ENSMUST00000071215.2 ENSMUST00000071215.3 ENSMUST00000071215.4 Mrps37 NM_025366 Q56A12 Q9CQA6 uc007skm.1 uc007skm.2 uc007skm.3 uc007skm.4 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Nucleus Belongs to the mitochondrion-specific ribosomal protein mS37 family. fibrillar center nucleus nucleoplasm mitochondrion mitochondrial ribosome cytosol ribosome biological_process mitochondrial translation uc007skm.1 uc007skm.2 uc007skm.3 uc007skm.4 
ENSMUST00000071230.8 Eif2s1 ENSMUST00000071230.8 eukaryotic translation initiation factor 2, subunit 1 alpha (from RefSeq NM_026114.3) ENSMUST00000071230.1 ENSMUST00000071230.2 ENSMUST00000071230.3 ENSMUST00000071230.4 ENSMUST00000071230.5 ENSMUST00000071230.6 ENSMUST00000071230.7 Eif2a Eif2s1 IF2A_MOUSE NM_026114 Q3TIQ0 Q6ZWX6 uc007nzk.1 uc007nzk.2 uc007nzk.3 Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:15277680, PubMed:19131336). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex (PubMed:15277680, PubMed:19131336). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:15277680, PubMed:19131336). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:15277680, PubMed:19131336). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap- dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1- mediated reprogramming (PubMed:15277680, PubMed:21285359). Activity is regulated by phosphorylation at Ser-49 and Ser-52, which stabilizes the eIF2/GDP/eIF2B complex and prevents the eIF2B-mediated exchange of GDP for GTP, thereby preventing the formation of the 43S pre-initiation complex (43S PIC) (PubMed:11106749, PubMed:12176355, PubMed:15277680, PubMed:19131336, PubMed:21285359). This results in the global attenuation of 5' cap-dependent protein synthesis and concomitant translation of ISR-specific mRNAs that contain a short upstream open reading frame (uORF) in their 5' UTR, such as ATF4, ATF5, DDIT3/CHOP and PPP1R15A/GADD34 (PubMed:15277680, PubMed:19131336, PubMed:21285359). Eukaryotic translation initiation factor 2 eIF2 is a heterotrimeric complex composed of an alpha (EIF2S1), a beta (EIF2S2) and a gamma (EIF2S3) chain (By similarity). eIF2 is member of the 43S pre-initiation complex (43S PIC). eIF2 forms a complex with at least CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (PubMed:16931514). Interaction with METAP2 protects EIF2S1 from inhibitory phosphorylation (By similarity). Interacts with ABCF1 (By similarity). Associates with ribosomes (By similarity). Interacts with DDX3X in an RNA-independent manner (By similarity). Q6ZWX6; Q9Z2R9: Eif2ak1; NbExp=6; IntAct=EBI-1202234, EBI-642878; Cytoplasm, Stress granule Cytoplasm, cytosol Note=Colocalizes with NANOS3 in the stress granules. Phosphorylation at Ser-49 and Ser-52 stabilizes the eIF- 2/GDP/eIF2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF2 between successive rounds of initiation and leading to global inhibition of translation, while concomitantly initiating the preferential translation of integrated stress response (ISR)-specific mRNAs (PubMed:10504407, PubMed:11106749, PubMed:12176355, PubMed:15213227, PubMed:15277680, PubMed:16054071, PubMed:19131336, PubMed:21285359). Substrate for at least 4 kinases: EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2 (PubMed:10504407, PubMed:11106749, PubMed:12176355, PubMed:15213227, PubMed:15277680, PubMed:16054071). Phosphorylated; phosphorylation on Ser-52 by the EIF2AK4/GCN2 protein kinase occurs in response to amino acid starvation and UV irradiation (PubMed:10504407, PubMed:12176355, PubMed:15213227, PubMed:16054071). Belongs to the eIF-2-alpha family. This gene should not be confused with EIF2A, with which it shares the alias EIF2A. Although both of these proteins function in binding initiator tRNA to the 40S ribosomal subunit, the eIF2 complex requires GTP, whereas the EIF2A protein does so in a codon-dependent manner. nucleic acid binding RNA binding translation initiation factor activity protein binding nucleus cytoplasm eukaryotic translation initiation factor 2 complex eukaryotic translation initiation factor 2B complex translation translational initiation regulation of translation aging cytoplasmic stress granule negative regulation of translational initiation in response to stress eukaryotic 48S preinitiation complex stress granule assembly cellular response to amino acid starvation cellular response to oxidative stress cellular response to heat cellular response to UV response to endoplasmic reticulum stress ribosome binding regulation of translational initiation in response to stress multi-eIF complex translation initiation ternary complex synapse protein autophosphorylation glial limiting end-foot positive regulation of neuron death negative regulation of guanyl-nucleotide exchange factor activity response to manganese-induced endoplasmic reticulum stress positive regulation of type B pancreatic cell apoptotic process uc007nzk.1 uc007nzk.2 uc007nzk.3 
ENSMUST00000071242.5 Or56a42-ps1 ENSMUST00000071242.5 Or56a42-ps1 (from geneSymbol) ENSMUST00000071242.1 ENSMUST00000071242.2 ENSMUST00000071242.3 ENSMUST00000071242.4 uc291tws.1 uc291tws.2 uc291tws.1 uc291tws.2 
ENSMUST00000071250.13 Pygl ENSMUST00000071250.13 liver glycogen phosphorylase (from RefSeq NM_133198.2) ENSMUST00000071250.1 ENSMUST00000071250.10 ENSMUST00000071250.11 ENSMUST00000071250.12 ENSMUST00000071250.2 ENSMUST00000071250.3 ENSMUST00000071250.4 ENSMUST00000071250.5 ENSMUST00000071250.6 ENSMUST00000071250.7 ENSMUST00000071250.8 ENSMUST00000071250.9 NM_133198 PYGL_MOUSE Pygl Q3UKJ0 Q9ET01 uc007ntm.1 uc007ntm.2 uc007ntm.3 uc007ntm.4 Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. Reaction=[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate; Xref=Rhea:RHEA:41732, Rhea:RHEA-COMP:9584, Rhea:RHEA-COMP:9586, ChEBI:CHEBI:15444, ChEBI:CHEBI:43474, ChEBI:CHEBI:58601; EC=2.4.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41733; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Allosterically regulated through the non-covalent binding of metabolites, being activated by AMP and inhibited by ATP, ADP, and glucose-6-phosphate. The activity is also controlled by post- translational modifications including phosphorylation and acetylation. Homodimer; enzymatically active. Interacts with PPP1R3B; recruits the phosphatase PP1 which dephosphorylates and inactivates PYGL/glycogen phosphorylase. Cytoplasm, cytosol Acetylation, which is up-regulated by glucose and insulin and down-regulated by glucagon, inhibits the glycogen phosphorylase activity by promoting PPP1R3B-mediated recruitment of phosphatase PP1 and Ser-15 dephosphorylation. Phosphorylation at Ser-15 converts inactive phosphorylase b into active phosphorylase a. Dephosphorylation of Ser-15 by phosphatase PP1 inactivates the enzyme. Belongs to the glycogen phosphorylase family. nucleotide binding purine nucleobase binding catalytic activity phosphorylase activity protein binding ATP binding cytoplasm carbohydrate metabolic process glycogen metabolic process glycogen catabolic process 5-phosphoribose 1-diphosphate biosynthetic process drug binding metabolic process glycogen phosphorylase activity response to bacterium AMP binding transferase activity transferase activity, transferring glycosyl groups vitamin binding pyridoxal phosphate binding carbohydrate binding bile acid binding glucose homeostasis protein homodimerization activity necroptotic process uc007ntm.1 uc007ntm.2 uc007ntm.3 uc007ntm.4 
ENSMUST00000071263.7 Dnajc30 ENSMUST00000071263.7 DnaJ heat shock protein family (Hsp40) member C30 (from RefSeq NM_025362.3) DJC30_MOUSE Dnajc30 ENSMUST00000071263.1 ENSMUST00000071263.2 ENSMUST00000071263.3 ENSMUST00000071263.4 ENSMUST00000071263.5 ENSMUST00000071263.6 NM_025362 P59041 Wbscr18 uc008zxp.1 uc008zxp.2 uc008zxp.3 Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (PubMed:30318146). Associates with the ATP synthase complex and facilitates ATP synthesis (PubMed:30318146). May be a chaperone protein involved in the turnover of the subunits of mitochondrial complex I N-module. It facilitates the degradation of N-module subunits damaged by oxidative stress, and contributes to complex I functional efficiency (By similarity). Associates with the ATP synthase complex. Interacts with MT- ATP6; interaction is direct. Interacts with ATP5MC2; interaction is direct. Mitochondrion inner membrane ; Single-pass membrane protein In brain, expressed in gray matter structures. Mice are smaller and have a decreased weight (PubMed:30318146). Neocortical projection neurons display morphological defects reminiscent of Williams-Beuren syndrome (WBS) in human, characterized by less complex dendritic architecture and a smaller corpus callosum (PubMed:30318146). Mitochondria show decreased ATP production (PubMed:30318146). Mice do not show significant systemic metabolic defects (PubMed:30318146). mitochondrion mitochondrial inner membrane ATP biosynthetic process brain development membrane integral component of membrane regulation of mitochondrial ATP synthesis coupled proton transport uc008zxp.1 uc008zxp.2 uc008zxp.3 
ENSMUST00000071268.11 Taok2 ENSMUST00000071268.11 TAO kinase 2, transcript variant 1 (from RefSeq NM_001163774.2) ENSMUST00000071268.1 ENSMUST00000071268.10 ENSMUST00000071268.2 ENSMUST00000071268.3 ENSMUST00000071268.4 ENSMUST00000071268.5 ENSMUST00000071268.6 ENSMUST00000071268.7 ENSMUST00000071268.8 ENSMUST00000071268.9 Kiaa0881 NM_001163774 Q6ZQ29 Q7TSS8 TAOK2_MOUSE uc009jtg.1 uc009jtg.2 uc009jtg.3 uc009jtg.4 Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with MAP2K3 and MAP2K6 (By similarity). Self- associates. Interacts with tubulins. Interacts with MAP3K7 and interferes with MAP3K7-binding to CHUK and thus prevents NF-kappa-B activation (By similarity). Isoform 2 interacts with PCDH8; this complex may also include CDH2 (By similarity). Cytoplasmic vesicle membrane ; Multi-pass membrane protein Cytoplasm, cytoskeleton Note=Found to be perinuclear and localized to vesicular compartment. [Isoform 2]: Cell projection, dendrite Note=In dendrites, colocalizes with PCDH8. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZQ29-1; Sequence=Displayed; Name=2; IsoId=Q6ZQ29-2; Sequence=VSP_040543, VSP_040544; Autophosphorylated. Phosphorylated by ATM (By similarity). [Isoform 2]: Phosphorylated on Ser-1037 by MAPK14. This phosphorylation is required PCDH8 for endocytosis (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Sequence=AAH52933.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N- and C-terminal parts.; Evidence=; Sequence=BAC98045.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding activation of MAPKK activity protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity ATP binding nucleus nucleolus cytoplasm cytosol cytoskeleton protein phosphorylation cellular response to DNA damage stimulus mitotic G2 DNA damage checkpoint axonogenesis regulation of cell shape membrane integral component of membrane kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation actin cytoskeleton organization axon dendrite cytoplasmic vesicle membrane cytoplasmic vesicle mitogen-activated protein kinase kinase binding activation of protein kinase activity positive regulation of stress-activated MAPK cascade regulation of actin cytoskeleton organization neuropilin binding cell projection neuron projection receptor complex dendritic growth cone axonal growth cone positive regulation of JNK cascade focal adhesion assembly stress-activated MAPK cascade actin cytoskeleton uc009jtg.1 uc009jtg.2 uc009jtg.3 uc009jtg.4 
ENSMUST00000071281.5 Foxb1 ENSMUST00000071281.5 forkhead box B1 (from RefSeq NM_022378.3) ENSMUST00000071281.1 ENSMUST00000071281.2 ENSMUST00000071281.3 ENSMUST00000071281.4 FOXB1_MOUSE Fkh5 Foxb1a Foxb1b Mf3 NM_022378 O08753 Q2M2M4 Q64732 uc012gwj.1 uc012gwj.2 Transcription factor expressed by neural progenitor cells in specific regions of the embryonic neuroepithelium (PubMed:28725186, PubMed:15654859). Essential for the mammillary nuclei maintenance (PubMed:15654859). Negatively regulates the proliferation of oligodendrocyte progenitors and promotes oligodendrocyte maturation (PubMed:28725186). Also expressed in mammary glands, plays a role in lactation, controls development of mammary glands and the inferior colliculi of the midbrain in the central nervous system that regulates the milk-ejection reflex (PubMed:11170346). Nucleus Expressed widespread in the early developing ventricular zone of the neural tube and later restricted to areas of the spinal cord, hindbrain, thalamus and hypothalamus (PubMed:28725186, PubMed:27292133, PubMed:15654859, PubMed:11170346). Expressed in epithelial cells of developing and adult mammary glands (PubMed:11170346). Expressed in oligodendrocyte-generating regions of the embryonic hindbrain. Mutants suffer perinatal degeneration of the medial and most of the lateral mammillary nuclei, as well as of the mammillothalamic bundle. Mutants show no deficits in hippocampal- dependent tasks as contextual fear conditioning and social transmission of food preference. They have a highly specific memory deficit, restricted to the performance of spatial working memory tasks with no impairment of spatial reference memory (PubMed:15654859). Female mutants have lactation defects with mammary glands with incomplete lobuloavelor development and morphological defects in the inferior colliculi of the midbrain (PubMed:11170346). RNA polymerase II transcription factor activity, sequence-specific DNA binding urogenital system development somitogenesis DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter axon target recognition lactation visual learning anatomical structure morphogenesis spinal cord development mammillary body development thalamus development hypothalamus cell migration telencephalon cell migration cell differentiation midbrain development floor plate development negative regulation of neuron apoptotic process sequence-specific DNA binding epithelial cell differentiation involved in mammary gland alveolus development mammillothalamic axonal tract development mammary gland lobule development inferior colliculus development cell migration in diencephalon uc012gwj.1 uc012gwj.2 
ENSMUST00000071302.3 Prr23a2 ENSMUST00000071302.3 proline rich 23A, member 2 (from RefSeq NM_001134661.1) D3YWX5 D3YWX5_MOUSE ENSMUST00000071302.1 ENSMUST00000071302.2 Gm6406 NM_001134661 Prr23a2 uc012gyv.1 uc012gyv.2 uc012gyv.3 Belongs to the PRR23 family. molecular_function cellular_component biological_process uc012gyv.1 uc012gyv.2 uc012gyv.3 
ENSMUST00000071308.6 Semp2l2a ENSMUST00000071308.6 SUMO/sentrin specific peptidase 2-like 2A (from RefSeq NM_153093.4) AF366264 ENSMUST00000071308.1 ENSMUST00000071308.2 ENSMUST00000071308.3 ENSMUST00000071308.4 ENSMUST00000071308.5 G3X9P9 G3X9P9_MOUSE NM_153093 Semp2l2a uc012gaa.1 uc012gaa.2 uc012gaa.3 uc012gaa.4 Belongs to the peptidase C48 family. nucleus proteolysis cysteine-type peptidase activity protein desumoylation uc012gaa.1 uc012gaa.2 uc012gaa.3 uc012gaa.4 
ENSMUST00000071325.9 Nf1 ENSMUST00000071325.9 neurofibromin 1 (from RefSeq NM_010897.2) ENSMUST00000071325.1 ENSMUST00000071325.2 ENSMUST00000071325.3 ENSMUST00000071325.4 ENSMUST00000071325.5 ENSMUST00000071325.6 ENSMUST00000071325.7 ENSMUST00000071325.8 NF1_MOUSE NM_010897 Q04690 Q61956 Q61957 uc007kkl.1 uc007kkl.2 uc007kkl.3 Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. Interacts with HTR6. Interacts with SPRED2. Nucleus Nucleus, nucleolus Cell membrane Event=Alternative splicing; Named isoforms=4; Name=II ; IsoId=Q04690-1; Sequence=Displayed; Name=I ; IsoId=Q04690-2; Sequence=VSP_001633; Name=III ; IsoId=Q04690-3; Sequence=VSP_001634, VSP_001635; Name=IV ; IsoId=Q04690-4; Sequence=VSP_001633, VSP_001634, VSP_001635; [Isoform I]: Expressed predominantly in brain, spinal cord and testis. [Isoform II]: Expressed predominantly in adrenal gland, kidney, ovary and lung. [Isoform III]: Widely and more weakly expressed. Predominantly expressed in adrenal gland. [Isoform IV]: Widely and more weakly expressed. Expressed mainly in testis. Binds phospholipids via a region that includes the CRAL-TRIO domain. Binds primarily glycerophospholipids with monounsaturated C18:1 and/or C16:1 fatty acid moieties and a phosphatidylethanolamine or phosphatidylcholine headgroup. Has lesser affinity for lipids containing phosphatidylserine and phosphatidylinositol (By similarity). MAPK cascade osteoblast differentiation metanephros development response to hypoxia liver development negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation regulation of cell-matrix adhesion negative regulation of cell-matrix adhesion GTPase activator activity protein binding nucleus nucleolus cytoplasm negative regulation of protein kinase activity cell communication signal transduction Ras protein signal transduction negative regulation of neuroblast proliferation brain development peripheral nervous system development heart development skeletal muscle tissue development microtubule binding negative regulation of cell proliferation lipid binding phosphatidylethanolamine binding visual learning extrinsic apoptotic signaling pathway via death domain receptors regulation of gene expression positive regulation of neuron projection development Schwann cell development phosphatidylinositol 3-kinase signaling postsynaptic density membrane negative regulation of angiogenesis spinal cord development amygdala development forebrain astrocyte development neural tube development cerebral cortex development myelination in peripheral nervous system actin cytoskeleton organization extracellular matrix organization collagen fibril organization adrenal gland development negative regulation of cell migration axon dendrite phosphatidylcholine binding regulation of synaptic transmission, GABAergic macromolecular complex cellular response to heat negative regulation of Rac protein signal transduction wound healing regulation of cell proliferation negative regulation of protein import into nucleus neuron projection positive regulation of apoptotic process regulation of GTPase activity negative regulation of MAP kinase activity regulation of MAPK cascade negative regulation of MAPK cascade pigmentation positive regulation of neuron apoptotic process regulation of blood vessel endothelial cell migration positive regulation of GTPase activity regulation of bone resorption syndecan binding regulation of neuron differentiation negative regulation of osteoclast differentiation regulation of glial cell differentiation positive regulation of adenylate cyclase activity regulation of angiogenesis negative regulation of Ras protein signal transduction negative regulation of neurotransmitter secretion negative regulation of fibroblast proliferation regulation of long-term neuronal synaptic plasticity sympathetic nervous system development camera-type eye morphogenesis negative regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation smooth muscle tissue development hair follicle maturation artery morphogenesis forebrain morphogenesis cognition gamma-aminobutyric acid secretion, neurotransmission glutamate secretion, neurotransmission observational learning presynapse regulation of long-term synaptic potentiation positive regulation of extrinsic apoptotic signaling pathway in absence of ligand uc007kkl.1 uc007kkl.2 uc007kkl.3 
ENSMUST00000071329.8 Bckdha ENSMUST00000071329.8 branched chain ketoacid dehydrogenase E1, alpha polypeptide, transcript variant 2 (from RefSeq NM_007533.6) Bckdha ENSMUST00000071329.1 ENSMUST00000071329.2 ENSMUST00000071329.3 ENSMUST00000071329.4 ENSMUST00000071329.5 ENSMUST00000071329.6 ENSMUST00000071329.7 NM_007533 Q3U3J1 Q3U3J1_MOUSE uc009fth.1 uc009fth.2 uc009fth.3 uc009fth.4 Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. Reaction=3-methyl-2-oxobutanoate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl- [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] = CO2 + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl- [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]; Xref=Rhea:RHEA:13457, Rhea:RHEA-COMP:10488, Rhea:RHEA-COMP:10489, ChEBI:CHEBI:11851, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:83099, ChEBI:CHEBI:83142; EC=1.2.4.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13458; Evidence=; Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Belongs to the BCKDHA family. alpha-ketoacid dehydrogenase activity 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity branched-chain amino acid catabolic process oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor oxidation-reduction process uc009fth.1 uc009fth.2 uc009fth.3 uc009fth.4 
ENSMUST00000071370.7 Pcdh17 ENSMUST00000071370.7 protocadherin 17 (from RefSeq NM_001013753.2) E9PXF0 E9PXF0_MOUSE ENSMUST00000071370.1 ENSMUST00000071370.2 ENSMUST00000071370.3 ENSMUST00000071370.4 ENSMUST00000071370.5 ENSMUST00000071370.6 NM_001013753 Pcdh17 uc007utp.1 uc007utp.2 uc007utp.3 uc007utp.4 This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Sep 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147265.1, SRR1660813.181429.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane adult behavior negative regulation of synaptic transmission glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane synaptic membrane adhesion presynaptic active zone assembly regulation of synaptic vesicle clustering uc007utp.1 uc007utp.2 uc007utp.3 uc007utp.4 
ENSMUST00000071378.6 Ifnab ENSMUST00000071378.6 interferon alpha B (from RefSeq NM_008336.2) ENSMUST00000071378.1 ENSMUST00000071378.2 ENSMUST00000071378.3 ENSMUST00000071378.4 ENSMUST00000071378.5 If1ai8 Ifnab L7MTU6 L7MTU6_MOUSE NM_008336 uc008tnj.1 uc008tnj.2 uc008tnj.3 Secreted Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tnj.1 uc008tnj.2 uc008tnj.3 
ENSMUST00000071402.7 Elovl6 ENSMUST00000071402.7 ELOVL fatty acid elongase 6 (from RefSeq NM_130450.2) ELOV6_MOUSE ENSMUST00000071402.1 ENSMUST00000071402.2 ENSMUST00000071402.3 ENSMUST00000071402.4 ENSMUST00000071402.5 ENSMUST00000071402.6 Elovl6 Face Lce Masr NM_130450 Q8CE45 Q920L5 uc008rid.1 uc008rid.2 uc008rid.3 Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long- chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=2.3.1.199; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32728; Evidence=; Reaction=H(+) + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35315, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57384, ChEBI:CHEBI:71407; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35316; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)- octadecenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:39675, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:61540, ChEBI:CHEBI:76555; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39676; Evidence=; Reaction=dodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetradecanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:60140, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:57384, ChEBI:CHEBI:62543; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60141; Evidence=; Reaction=H(+) + malonyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:39167, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57349, ChEBI:CHEBI:57384, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39168; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3- oxoicosenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36511, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:57387, ChEBI:CHEBI:74011; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36512; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)- 3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36503, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:57384, ChEBI:CHEBI:74012; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36504; Evidence=; Reaction=(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36523, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74034, ChEBI:CHEBI:74054; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36524; Evidence=; The reaction is stimulated by the presence of HSD17B12, the enzyme catalyzing the second step of the elongation cycle. pH dependence: Optimum pH is 6.5 at 37 degrees Celsius with hexadecanoyl-CoA as substrate. ; Lipid metabolism; fatty acid biosynthesis. Endoplasmic reticulum membrane ulti-pass membrane protein Highly expressed in adrenal gland, liver, white adipose tissue (WAT), adult and fetal brain, cerebellum, spinal cord, testis, skin and peripheral nerve; where lipogenesis and steroidogenesis are active. Weakly expressed in kidney, heart, skeletal muscle, lung, and spleen. By SREBF1. N-Glycosylated. Homozygous knockout mice lacking Elovl6 are partially viable and surviving animals are fertile. Mutant mice appear grossly normal and slightly but significantly leaner than wild-type littermates. Hepatic concentrations of stearate (C18:0) and oleate (C18:1n-9) are lowered, whereas those of palmitate (C16:0) and palmitoleate (C16:1n7) are increased. Elovl6 deletion abrogates the development of diet-induced insulin resistance. Belongs to the ELO family. ELOVL6 subfamily. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process fatty acid elongase activity membrane integral component of membrane transferase activity transferase activity, transferring acyl groups other than amino-acyl groups fatty acid elongation, saturated fatty acid sphingolipid biosynthetic process integral component of endoplasmic reticulum membrane fatty acid elongation fatty acid elongation, monounsaturated fatty acid fatty acid elongation, polyunsaturated fatty acid long-chain fatty-acyl-CoA biosynthetic process long-chain fatty acid biosynthetic process very long-chain fatty acid biosynthetic process 3-oxo-arachidoyl-CoA synthase activity 3-oxo-cerotoyl-CoA synthase activity 3-oxo-lignoceronyl-CoA synthase activity uc008rid.1 uc008rid.2 uc008rid.3 
ENSMUST00000071404.5 Ccr1l1 ENSMUST00000071404.5 C-C motif chemokine receptor 1 like 1 (from RefSeq NM_007718.4) A0JP35 CC1L1_MOUSE Cmkbr1l1 ENSMUST00000071404.1 ENSMUST00000071404.2 ENSMUST00000071404.3 ENSMUST00000071404.4 NM_007718 P51676 uc009sgz.1 uc009sgz.2 uc009sgz.3 uc009sgz.4 Probable receptor for a C-C type chemokine. Cell membrane; Multi-pass membrane protein. Detected in the spleen, liver and leukocytes. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity chemokine receptor activity cytoplasm plasma membrane chemotaxis inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration external side of plasma membrane membrane integral component of membrane C-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding chemokine (C-C motif) ligand 7 binding cell chemotaxis chemokine-mediated signaling pathway chemokine (C-C motif) ligand 5 binding positive regulation of monocyte chemotaxis uc009sgz.1 uc009sgz.2 uc009sgz.3 uc009sgz.4 
ENSMUST00000071421.6 Gm4871 ENSMUST00000071421.6 predicted gene 4871 (from RefSeq NM_001101463.1) D3Z0W7 D3Z0W7_MOUSE ENSMUST00000071421.1 ENSMUST00000071421.2 ENSMUST00000071421.3 ENSMUST00000071421.4 ENSMUST00000071421.5 Gm4871 NM_001101463 uc012egs.1 uc012egs.2 uc012egs.3 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc012egs.1 uc012egs.2 uc012egs.3 
ENSMUST00000071423.7 Nhlrc2 ENSMUST00000071423.7 NHL repeat containing 2 (from RefSeq NM_025811.3) ENSMUST00000071423.1 ENSMUST00000071423.2 ENSMUST00000071423.3 ENSMUST00000071423.4 ENSMUST00000071423.5 ENSMUST00000071423.6 NHLC2_MOUSE NM_025811 Q80XU0 Q8BZW8 uc008hzc.1 uc008hzc.2 uc008hzc.3 Required for normal embryonic development. Monomer. Cytoplasm, cytosol Ubiquitous. Full embryonic lethality. No homozygous embryos are present at 2.5 dpc. molecular_function cytoplasm cytosol biological_process cell redox homeostasis uc008hzc.1 uc008hzc.2 uc008hzc.3 
ENSMUST00000071430.7 2310039H08Rik ENSMUST00000071430.7 RIKEN cDNA 2310039H08 gene (from RefSeq NM_025966.3) CF226_MOUSE ENSMUST00000071430.1 ENSMUST00000071430.2 ENSMUST00000071430.3 ENSMUST00000071430.4 ENSMUST00000071430.5 ENSMUST00000071430.6 NM_025966 Q9D1N0 Q9D727 uc008cui.1 uc008cui.2 uc008cui.3 molecular_function cellular_component biological_process uc008cui.1 uc008cui.2 uc008cui.3 
ENSMUST00000071449.3 Or8c9 ENSMUST00000071449.3 olfactory receptor family 8 subfamily C member 9 (from RefSeq NM_146870.2) ENSMUST00000071449.1 ENSMUST00000071449.2 NM_146870 Olfr25 Or8c9 Q7TRD6 Q7TRD6_MOUSE uc009owe.1 uc009owe.2 uc009owe.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC125306.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009owe.1 uc009owe.2 uc009owe.3 
ENSMUST00000071465.9 Zkscan6 ENSMUST00000071465.9 zinc finger with KRAB and SCAN domains 6, transcript variant 3 (from RefSeq NM_001302375.1) ENSMUST00000071465.1 ENSMUST00000071465.2 ENSMUST00000071465.3 ENSMUST00000071465.4 ENSMUST00000071465.5 ENSMUST00000071465.6 ENSMUST00000071465.7 ENSMUST00000071465.8 NM_001302375 Q810A1 Q9D972 ZNF18_MOUSE Zfp535 Znf18 uc007jle.1 uc007jle.2 uc007jle.3 uc007jle.4 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated myelination negative regulation of transcription, DNA-templated metal ion binding uc007jle.1 uc007jle.2 uc007jle.3 uc007jle.4 
ENSMUST00000071492.9 Fam136a ENSMUST00000071492.9 family with sequence similarity 136, member A, transcript variant 1 (from RefSeq NM_025591.3) ENSMUST00000071492.1 ENSMUST00000071492.2 ENSMUST00000071492.3 ENSMUST00000071492.4 ENSMUST00000071492.5 ENSMUST00000071492.6 ENSMUST00000071492.7 ENSMUST00000071492.8 F136A_MOUSE NM_025591 Q91YY1 Q9CR98 uc009crl.1 uc009crl.2 uc009crl.3 Belongs to the FAM136 family. molecular_function cytoplasm mitochondrion biological_process uc009crl.1 uc009crl.2 uc009crl.3 
ENSMUST00000071526.6 Ctsj ENSMUST00000071526.6 cathepsin J, transcript variant 2 (from RefSeq NM_012007.2) A0A0R4J0V8 A0A0R4J0V8_MOUSE Ctsj ENSMUST00000071526.1 ENSMUST00000071526.2 ENSMUST00000071526.3 ENSMUST00000071526.4 ENSMUST00000071526.5 NM_012007 uc007qwa.1 uc007qwa.2 uc007qwa.3 uc007qwa.4 Lysosome Belongs to the peptidase C1 family. proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity perinuclear region of cytoplasm uc007qwa.1 uc007qwa.2 uc007qwa.3 uc007qwa.4 
ENSMUST00000071555.13 Actg1 ENSMUST00000071555.13 actin, gamma, cytoplasmic 1, transcript variant 1 (from RefSeq NM_009609.3) Actg1 ENSMUST00000071555.1 ENSMUST00000071555.10 ENSMUST00000071555.11 ENSMUST00000071555.12 ENSMUST00000071555.2 ENSMUST00000071555.3 ENSMUST00000071555.4 ENSMUST00000071555.5 ENSMUST00000071555.6 ENSMUST00000071555.7 ENSMUST00000071555.8 ENSMUST00000071555.9 NM_009609 Q4KL81 Q4KL81_MOUSE uc007msi.1 uc007msi.2 uc007msi.3 uc007msi.4 Actins are highly conserved proteins that are involved in various types of cell motility and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta, and gamma, have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Belongs to the actin family. nucleotide binding profilin binding ATP binding cytoplasm cytoskeleton actin filament plasma membrane focal adhesion ubiquitin protein ligase binding identical protein binding extracellular exosome dense body uc007msi.1 uc007msi.2 uc007msi.3 uc007msi.4 
ENSMUST00000071562.3 Ovca2 ENSMUST00000071562.3 candidate tumor suppressor in ovarian cancer 2 (from RefSeq NM_027136.3) ENSMUST00000071562.1 ENSMUST00000071562.2 NM_027136 OVCA2_MOUSE Q9D7E3 uc007kdf.1 uc007kdf.2 uc007kdf.3 Strongly expressed in kidney and liver. Moderately expressed in brain, skin and testis. Weakly expressed in heart, lung, small intestine, spleen, stomach and thymus. Expressed in embryonic stem (ES) cells. Belongs to the LovG family. Encoded in an intron of the gene DPH1/OVCA1 (same strand). molecular_function nucleus cytoplasm hydrolase activity response to retinoic acid uc007kdf.1 uc007kdf.2 uc007kdf.3 
ENSMUST00000071564.14 Fbh1 ENSMUST00000071564.14 F-box DNA helicase 1, transcript variant 1 (from RefSeq NM_015792.2) ENSMUST00000071564.1 ENSMUST00000071564.10 ENSMUST00000071564.11 ENSMUST00000071564.12 ENSMUST00000071564.13 ENSMUST00000071564.2 ENSMUST00000071564.3 ENSMUST00000071564.4 ENSMUST00000071564.5 ENSMUST00000071564.6 ENSMUST00000071564.7 ENSMUST00000071564.8 ENSMUST00000071564.9 FBH1_MOUSE Fbh1 Fbx18 Fbxo18 NM_015792 Q8C444 Q8K2I9 Q99KS0 Q9CTC6 Q9QZG7 uc008ijc.1 uc008ijc.2 uc008ijc.3 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:24108124). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (By similarity). Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.; EC=5.6.2.4; Evidence=; Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4; Evidence=; Protein modification; protein ubiquitination. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBH1) composed of CUL1, SKP1, RBX1 and FBH1 (By similarity). Interacts with RPA2 (By similarity). Interacts with RAD51 (PubMed:24108124). Interacts (via PIP-box and RanBP2-type zinc finger) with PCNA (By similarity). Nucleus Chromosome Note=Accumulates at sites of DNA damage or replication stress. PCNA is required for localization to DNA damage sites. Localizes to the nucleoplasm in absence of DNA damage. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2I9-1; Sequence=Displayed; Name=2; IsoId=Q8K2I9-2; Sequence=VSP_009716, VSP_009717; The PIP-box mediates the interaction with PCNA. Ubiquitinated. Ubiquitination by the DCX(DTL) complex, also named CRL4(CDT2), leading to its degradation: ubiquitination takes place after its localization to DNA damage sites, possibly to facilitate the translesion synthesis (TLS) pathway. Belongs to the helicase family. UvrD subfamily. nucleotide binding double-strand break repair via homologous recombination recombinational repair DNA catabolic process, endonucleolytic chromatin positive regulation of protein phosphorylation DNA binding DNA helicase activity double-stranded DNA binding single-stranded DNA binding helicase activity protein binding ATP binding nucleus chromosome DNA repair cellular response to DNA damage stimulus cell death DNA translocase activity protein ubiquitination hydrolase activity SCF ubiquitin ligase complex replication fork processing DNA duplex unwinding negative regulation of chromatin binding 3'-5' DNA helicase activity replication fork protection response to intra-S DNA damage checkpoint signaling positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of double-strand break repair via homologous recombination uc008ijc.1 uc008ijc.2 uc008ijc.3 
ENSMUST00000071580.8 Pramel51 ENSMUST00000071580.8 PRAME like 51, transcript variant 1 (from RefSeq NM_001105254.1) ENSMUST00000071580.1 ENSMUST00000071580.2 ENSMUST00000071580.3 ENSMUST00000071580.4 ENSMUST00000071580.5 ENSMUST00000071580.6 ENSMUST00000071580.7 L7N1Y3 L7N1Y3_MOUSE NM_001105254 Pramel51 uc011yps.1 uc011yps.2 uc011yps.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc011yps.1 uc011yps.2 uc011yps.3 
ENSMUST00000071585.10 Oprl1 ENSMUST00000071585.10 opioid receptor-like 1, transcript variant 1 (from RefSeq NM_011012.6) ENSMUST00000071585.1 ENSMUST00000071585.2 ENSMUST00000071585.3 ENSMUST00000071585.4 ENSMUST00000071585.5 ENSMUST00000071585.6 ENSMUST00000071585.7 ENSMUST00000071585.8 ENSMUST00000071585.9 NM_011012 Oprl1 Q542U1 Q542U1_MOUSE uc008onk.1 uc008onk.2 uc008onk.3 The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]. G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. nociceptin receptor activity G-protein coupled receptor activity opioid receptor activity integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway protein C-terminus binding membrane integral component of membrane response to estradiol positive regulation of urine volume opioid receptor signaling pathway eating behavior negative regulation of cAMP-mediated signaling estrous cycle negative regulation of blood pressure positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway regulation of sensory perception of pain positive regulation of gastric acid secretion negative regulation of voltage-gated calcium channel activity positive regulation of sensory perception of pain regulation of locomotor rhythm conditioned place preference uc008onk.1 uc008onk.2 uc008onk.3 
ENSMUST00000071588.8 Nkx6-3 ENSMUST00000071588.8 NK6 homeobox 3 (from RefSeq NM_029002.2) ENSMUST00000071588.1 ENSMUST00000071588.2 ENSMUST00000071588.3 ENSMUST00000071588.4 ENSMUST00000071588.5 ENSMUST00000071588.6 ENSMUST00000071588.7 NKX63_MOUSE NM_029002 Q3UHX8 Q4JGN0 Q9D2W8 uc009len.1 uc009len.2 uc009len.3 Putative transcription factor, which may be involved in patterning of central nervous system and pancreas. Nucleus Expressed in the developing CNS and gastro- intestinal tract. In the developing embryo, it is confined to the gut and caudal hindbrain. In caudal hindbrain, it is specifically expressed in a subpopulation of differentiating V2 neurons. Not detected prior to 12.5 dpc and is not found in motor nuclei. At 12.5 dpc, it is expressed in the ventral medial aspect of the medullary reticular formation (MDR). At 16.5 dpc, expression is confined to the gigantocellular nucleus, a nucleus that is part of the MDR. In addition to the CNS, it is also expressed in the developing gut, in duodenal and glandular stomach endoderm and, at the end of gestation becomes restricted to the base of the gastric units in the glandular stomach. Expressed at very low level in the pancreatic epithelium. Expressed in the pancreas at 15.5 dpc. RNA polymerase II core promoter proximal region sequence-specific DNA binding cell fate determination glandular epithelial cell differentiation DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated cell differentiation negative regulation of epithelial cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc009len.1 uc009len.2 uc009len.3 
ENSMUST00000071592.12 Prmt7 ENSMUST00000071592.12 protein arginine N-methyltransferase 7 (from RefSeq NM_145404.1) ANM7_MOUSE ENSMUST00000071592.1 ENSMUST00000071592.10 ENSMUST00000071592.11 ENSMUST00000071592.2 ENSMUST00000071592.3 ENSMUST00000071592.4 ENSMUST00000071592.5 ENSMUST00000071592.6 ENSMUST00000071592.7 ENSMUST00000071592.8 ENSMUST00000071592.9 Kiaa1933 NM_145404 Q3TRZ6 Q69Z62 Q6B955 Q6PG80 Q922X9 uc009nfu.1 uc009nfu.2 uc009nfu.3 Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo (By similarity). Reaction=L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48100, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:11990, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65280; EC=2.1.1.321; Evidence=; Homodimer and heterodimer. Interacts with PRMT5 and SNRPD3 (By similarity). Interacts with CTCFL. Q922X9; A2APF3: Ctcfl; NbExp=3; IntAct=EBI-15606508, EBI-11566304; Cytoplasm, cytosol Nucleus Present in undifferentiated embryonic stem and germ cells; expression is lost when cells differentiate. In the developing testis, it is expressed at all stages. Present in all cells within the developing tubule, including gonocytes and spermatogonia (at protein level). It the developing kidney, it is confined to the nephrogenic zone in the cortical region, where the tips of the ureteric bud induce de novo formation of epithelia in the metanephric mesenchyme and early glomeruli. Expression is around 8-fold lower in adult kidneys. Mutants, shortly after birth, display significant reduced body size, reduced weight and shortened fifth metatarsals. They are subviable with about 45% of the expected number of mutant pups at P14. Surviving adult mice exhibit increased fat mass, reduced length and limb abnormalities. They also have reduced bone mineral content and density. Knockout mice show sexually dimorphic phenotypes, including changes in bone mineral content, bone mineral density and fifth metacarpal length that are only significant in females. Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily. Sequence=BAD32582.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; spliceosomal snRNP assembly fibrillar center protein binding nucleus nucleoplasm cytoplasm cytosol chromatin organization regulation of gene expression by genetic imprinting protein methylation methyltransferase activity histone-arginine N-methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity [myelin basic protein]-arginine N-methyltransferase activity histone methylation transferase activity peptidyl-arginine methylation peptidyl-arginine methylation, to symmetrical-dimethyl arginine cell differentiation methylation histone arginine methylation protein-arginine omega-N monomethyltransferase activity protein-arginine omega-N symmetric methyltransferase activity peptidyl-arginine N-methylation peptidyl-arginine omega-N-methylation ribonucleoprotein complex binding DNA methylation involved in gamete generation histone H4-R3 methylation histone methyltransferase activity (H4-R3 specific) uc009nfu.1 uc009nfu.2 uc009nfu.3 
ENSMUST00000071617.6 Or8g26 ENSMUST00000071617.6 olfactory receptor family 8 subfamily G member 26 (from RefSeq NM_146326.3) ENSMUST00000071617.1 ENSMUST00000071617.2 ENSMUST00000071617.3 ENSMUST00000071617.4 ENSMUST00000071617.5 NM_146326 Olfr943 Or8g26 Q9EQ92 Q9EQ92_MOUSE uc009oxr.1 uc009oxr.2 uc009oxr.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB174114.1, CB174399.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oxr.1 uc009oxr.2 uc009oxr.3 
ENSMUST00000071641.6 ENSMUSG00000121777 ENSMUST00000071641.6 ENSMUSG00000121777 (from geneSymbol) AK088036 ENSMUST00000071641.1 ENSMUST00000071641.2 ENSMUST00000071641.3 ENSMUST00000071641.4 ENSMUST00000071641.5 uc291uqs.1 uc291uqs.2 uc291uqs.3 uc291uqs.1 uc291uqs.2 uc291uqs.3 
ENSMUST00000071646.2 Rdh16 ENSMUST00000071646.2 retinol dehydrogenase 16 (from RefSeq NM_009040.3) Crad Crad1 ENSMUST00000071646.1 NM_009040 O54909 RDH16_MOUSE Rdh1 Rdh16 Rdh6 uc007hkq.1 uc007hkq.2 uc007hkq.3 uc007hkq.4 Oxidoreductase with a preference for NAD. Oxidizes all-trans- retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction. Reaction=all-trans-retinol--[retinol-binding protein] + NAD(+) = all- trans-retinal--[retinol-binding protein] + H(+) + NADH; Xref=Rhea:RHEA:48488, Rhea:RHEA-COMP:14428, Rhea:RHEA-COMP:14430, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83228; EC=1.1.1.105; Evidence=; Reaction=9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH; Xref=Rhea:RHEA:42052, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78272, ChEBI:CHEBI:78273; Evidence=; Reaction=11-cis-retinol + NAD(+) = 11-cis-retinal + H(+) + NADH; Xref=Rhea:RHEA:42060, ChEBI:CHEBI:15378, ChEBI:CHEBI:16066, ChEBI:CHEBI:16302, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.315; Evidence=; Reaction=13-cis-retinol + NAD(+) = 13-cis-retinal + H(+) + NADH; Xref=Rhea:RHEA:42056, ChEBI:CHEBI:15378, ChEBI:CHEBI:45479, ChEBI:CHEBI:45487, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=androsterone + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:20381, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:16032, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.209; Evidence=; Reaction=5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta- hydroxy-5alpha-androstan-3-one + H(+) + NADH; Xref=Rhea:RHEA:42004, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:36713, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.53; Evidence=; Kinetic parameters: KM=0.2 uM for 3alpha-hydroxy-5alpha-androstan-17-one (androsterone) ; Cofactor metabolism; retinol metabolism. Homodimer. Endoplasmic reticulum membrane ingle-pass membrane protein Microsome membrane The C-terminal region plays a crucial role in controlling the activity of RDH16 and its required for endoplasmic reticulum (ER) retention. Not glycosylated. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Membrane topology is controversial (PubMed:16223484, PubMed:15355969). Membrane topology structure with endoplasmic reticulum lumen orientation of the catalytic domains while the C- terminus is in the cytosol have been suggested (PubMed:16223484, PubMed:11279029). Others investigators have argued for a reverse orientation, with a membrane-embedded N-terminal domain but no C- terminal transmembrane segment, and a cytosolic orientation of the catalytic domain (PubMed:15355969). These contradictory results are probably because of differences in the assay systems. retinoid metabolic process retinol dehydrogenase activity endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane lipid metabolic process steroid metabolic process membrane integral component of membrane oxidoreductase activity organelle membrane integral component of organelle membrane retinol metabolic process protein homodimerization activity 9-cis-retinoic acid biosynthetic process intracellular membrane-bounded organelle androsterone dehydrogenase activity androstan-3-alpha,17-beta-diol dehydrogenase activity oxidation-reduction process uc007hkq.1 uc007hkq.2 uc007hkq.3 uc007hkq.4 
ENSMUST00000071650.13 Idua ENSMUST00000071650.13 iduronidase, alpha-L, transcript variant 1 (from RefSeq NM_008325.4) ENSMUST00000071650.1 ENSMUST00000071650.10 ENSMUST00000071650.11 ENSMUST00000071650.12 ENSMUST00000071650.2 ENSMUST00000071650.3 ENSMUST00000071650.4 ENSMUST00000071650.5 ENSMUST00000071650.6 ENSMUST00000071650.7 ENSMUST00000071650.8 ENSMUST00000071650.9 Idua NM_008325 Q8BMG0 Q8BMG0_MOUSE uc008yov.1 uc008yov.2 uc008yov.3 uc008yov.4 uc008yov.5 Belongs to the glycosyl hydrolase 39 family. L-iduronidase activity hydrolase activity, hydrolyzing O-glycosyl compounds receptor binding lysosome carbohydrate metabolic process glycosaminoglycan catabolic process coated vesicle dermatan sulfate catabolic process heparin catabolic process uc008yov.1 uc008yov.2 uc008yov.3 uc008yov.4 uc008yov.5 
ENSMUST00000071652.6 Mthfd2l ENSMUST00000071652.6 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like (from RefSeq NM_026788.1) D3YZG8 ENSMUST00000071652.1 ENSMUST00000071652.2 ENSMUST00000071652.3 ENSMUST00000071652.4 ENSMUST00000071652.5 MTD2L_MOUSE Mthfd2l NM_026788 uc008ybp.1 uc008ybp.2 uc008ybp.3 uc008ybp.4 uc008ybp.5 Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)- 5,10-methenyltetrahydrofolate + NADH; Xref=Rhea:RHEA:22892, ChEBI:CHEBI:15636, ChEBI:CHEBI:57455, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.5.1.15; Evidence=; Reaction=(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10- formyltetrahydrofolate + H(+); Xref=Rhea:RHEA:23700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57455, ChEBI:CHEBI:195366; EC=3.5.4.9; Evidence=; Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)- 5,10-methenyltetrahydrofolate + NADPH; Xref=Rhea:RHEA:22812, ChEBI:CHEBI:15636, ChEBI:CHEBI:57455, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.5; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; One-carbon metabolism; tetrahydrofolate interconversion. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Widely expressed. Expressed at all embryonic days examined in the neural tube and the forebrain, midbrain, and hindbrain. Also detected in the branchial arches and limb buds, particularly along the progress zone. Expression is low at 8.5 dpc but increases at 10.5 dpc. Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. histidine biosynthetic process catalytic activity methenyltetrahydrofolate cyclohydrolase activity methylenetetrahydrofolate dehydrogenase (NAD+) activity methylenetetrahydrofolate dehydrogenase (NADP+) activity mitochondrion mitochondrial inner membrane mitochondrial matrix purine nucleotide biosynthetic process one-carbon metabolic process metabolic process cellular amino acid biosynthetic process methionine biosynthetic process 10-formyltetrahydrofolate metabolic process membrane oxidoreductase activity hydrolase activity tetrahydrofolate interconversion tetrahydrofolate metabolic process oxidation-reduction process uc008ybp.1 uc008ybp.2 uc008ybp.3 uc008ybp.4 uc008ybp.5 
ENSMUST00000071667.9 Siah1b ENSMUST00000071667.9 siah E3 ubiquitin protein ligase 1B, transcript variant 3 (from RefSeq NM_001308386.1) A2AHZ2 A2AHZ2_MOUSE ENSMUST00000071667.1 ENSMUST00000071667.2 ENSMUST00000071667.3 ENSMUST00000071667.4 ENSMUST00000071667.5 ENSMUST00000071667.6 ENSMUST00000071667.7 ENSMUST00000071667.8 NM_001308386 Siah1b uc057cge.1 uc057cge.2 uc057cge.3 This gene encodes a member of the seven in absentia homolog (Siah) family of E3 ubiquitin ligase enzymes that catalyze the transfer of ubiquitin to substrate proteins. The encoded protein targets Pard3A (partitioning defective 3A) protein for proteasome-mediated degradation during the exit of cerebellar granule neurons from their germinal zone niche. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence= Protein modification; protein ubiquitination. The RING-type zinc finger domain is essential for ubiquitin ligase activity. The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. Belongs to the SINA (Seven in absentia) family. nucleus ubiquitin-dependent protein catabolic process multicellular organism development zinc ion binding protein ubiquitination metal ion binding uc057cge.1 uc057cge.2 uc057cge.3 
ENSMUST00000071691.4 Taar7f ENSMUST00000071691.4 trace amine-associated receptor 7F (from RefSeq NM_001010839.1) B2RT90 ENSMUST00000071691.1 ENSMUST00000071691.2 ENSMUST00000071691.3 NM_001010839 Q5QD08 TAA7F_MOUSE uc007eqn.1 uc007eqn.2 Olfactory receptor activated by trace amine N- methylpiperidine. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase. Cell membrane ; Multi-pass membrane protein Specifically expressed in neurons of the olfactory epithelium. Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2- phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus G-protein coupled amine receptor activity membrane integral component of membrane uc007eqn.1 uc007eqn.2 
ENSMUST00000071696.2 Tas2r123 ENSMUST00000071696.2 taste receptor, type 2, member 123 (from RefSeq NM_207025.1) ENSMUST00000071696.1 NM_207025 P59528 Q7M714 T2r55 TR123_MOUSE Tas2r23 uc009ejq.1 uc009ejq.2 Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). Membrane; Multi-pass membrane protein. Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the duodenum, antrum and fundus (part of the stomach). Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. This protein was previously referred to as T2R2 but is now considered to be an ortholog of rat TAS2R23. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009ejq.1 uc009ejq.2 
ENSMUST00000071703.6 Tut7 ENSMUST00000071703.6 terminal uridylyl transferase 7, transcript variant 2 (from RefSeq NM_153538.3) E9PUA2 E9PUA2_MOUSE ENSMUST00000071703.1 ENSMUST00000071703.2 ENSMUST00000071703.3 ENSMUST00000071703.4 ENSMUST00000071703.5 NM_153538 Tut7 Zcchc6 uc007qvg.1 uc007qvg.2 uc007qvg.3 uc007qvg.4 Reaction=RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide; Xref=Rhea:RHEA:14785, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17348, ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:140395, ChEBI:CHEBI:173116; EC=2.7.7.52; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; nucleic acid binding nucleoplasm cytoplasm cytosol zinc ion binding negative regulation of transposition, RNA-mediated miRNA metabolic process nucleotidyltransferase activity pre-miRNA processing RNA 3'-end processing miRNA binding RNA uridylyltransferase activity uridylyltransferase activity RNA 3' uridylation uc007qvg.1 uc007qvg.2 uc007qvg.3 uc007qvg.4 
ENSMUST00000071707.3 Tas2r120 ENSMUST00000071707.3 taste receptor, type 2, member 120 (from RefSeq NM_207023.1) ENSMUST00000071707.1 ENSMUST00000071707.2 NM_207023 Q7M721 T2r47 TR120_MOUSE Tas2r120 uc009eji.1 uc009eji.2 uc009eji.3 Putative taste receptor which may play a role in the perception of bitterness. Membrane ; Multi-pass membrane protein Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009eji.1 uc009eji.2 uc009eji.3 
ENSMUST00000071711.4 Zfp36l3 ENSMUST00000071711.4 zinc finger protein 36, C3H type-like 3 (from RefSeq NM_001009549.2) ENSMUST00000071711.1 ENSMUST00000071711.2 ENSMUST00000071711.3 NM_001009549 Q5ISE2 Z36L3_MOUSE Zfp36l3 uc033jpz.1 uc033jpz.2 uc033jpz.3 Placenta-specific zinc-finger RNA-binding protein that destabilizes cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:15814898, PubMed:26952984). Binds to the 3'-UTR ARE of placental target mRNAs, such as TNF, HBEGF and LIPG (PubMed:15814898, PubMed:18367448, PubMed:26952984). Involved in placental expression of many genes important for normal placental physiology (PubMed:26952984). Cytoplasm mbrane ; Multi-pass membrane protein Note=Localizes exlusively in the cytoplasm (PubMed:18367448, PubMed:15814898). Not detected in the nucleus despite the presence of a nuclear localization signal (NLS) in the zinc finger regions; a C- terminal alanine-rich repeat domain is able to override the activity of the nuclear localization signal and prevent import into the nucleus (PubMed:18367448, PubMed:26493225). Expressed in placenta and extraembryonic tissues (at protein level). Not detected in embryos and fetus (PubMed:15814898, PubMed:26952984). Expressed in placenta at 14.5 dpc. Expressed in the single layer of endodermal epithelial cells of the visceral yolk sac at 15.5 dpc (PubMed:26952984). Expressed in syncytiotrophoblast and trophoblast giant cells of the labyrinth region of the placenta at 17.5 dpc (PubMed:15814898, PubMed:26952984) (at protein level). Expressed specifically in extraembryonic structures, in placenta from 9.5 to 18.5 and yolk sac/amnion from 12.5 to 18.5 (PubMed:15814898, PubMed:26952984). Expressed in the labyrinthine layer of the trophoblastic placenta at 10.5, 12.5 and 14.5 dpc (PubMed:15814898). Expressed in syncytiotrophoblast and trophoblast giant cells, less in spongiotrophoblast cells, and not detected in maternal decidua or in allantois at 17.5 dpc (PubMed:26952984). Contains long series of C-terminal alanine-rich repeats that serve to maintain the protein in the cytoplasm. Mice are viable and fertile, without apparent morphological or histological abnormalities in the placenta, but display a decrease in the numbers of surviving offspring. Display an abnormal accumulation of placental 3'UTR ARE-containing mRNAs. Exhibit also a decrease in ARE-containing mRNA decay in differentiated trophoblast stem cells. Rodent-specific retrogene derived apparently from its related family member ZFP36L2 mRNA (PubMed:15814898, PubMed:26493225). nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA poly(A) tail shortening DNA binding RNA binding cytoplasm membrane integral component of membrane mRNA 3'-UTR AU-rich region binding metal ion binding uc033jpz.1 uc033jpz.2 uc033jpz.3 
ENSMUST00000071718.12 Prdx6 ENSMUST00000071718.12 peroxiredoxin 6, transcript variant 1 (from RefSeq NM_007453.4) ENSMUST00000071718.1 ENSMUST00000071718.10 ENSMUST00000071718.11 ENSMUST00000071718.2 ENSMUST00000071718.3 ENSMUST00000071718.4 ENSMUST00000071718.5 ENSMUST00000071718.6 ENSMUST00000071718.7 ENSMUST00000071718.8 ENSMUST00000071718.9 NM_007453 Prdx6 Q6GT24 Q6GT24_MOUSE uc007dfl.1 uc007dfl.2 uc007dfl.3 uc007dfl.4 This gene encodes a member of the peroxiredoxin family of peroxidases. The encoded protein is a bifunctional enzyme that has glutathione peroxidase and phospholipase activities. This protein is an antioxidant that reduces peroxidized membrane phospholipids and plays an important role in phospholipid homeostasis based on its ability to generate lysophospholipid substrate for the remodeling pathway of phospholipid synthesis. Mice lacking this gene are sensitive to oxidant stress, have altered lung phospholipid metabolism and susceptible to skin tumorigenesis. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Dec 2014]. Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35983, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35984; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2- diacyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:12937, ChEBI:CHEBI:57287, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:58342; EC=2.3.1.23; Evidence=; Reaction=a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O; Xref=Rhea:RHEA:62632, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.27; Evidence= Cytoplasm Belongs to the peroxiredoxin family. Prx6 subfamily. cell antioxidant activity oxidoreductase activity cell redox homeostasis peroxiredoxin activity oxidation-reduction process cellular oxidant detoxification uc007dfl.1 uc007dfl.2 uc007dfl.3 uc007dfl.4 
ENSMUST00000071739.12 Gsk3a ENSMUST00000071739.12 glycogen synthase kinase 3 alpha (from RefSeq NM_001031667.1) ENSMUST00000071739.1 ENSMUST00000071739.10 ENSMUST00000071739.11 ENSMUST00000071739.2 ENSMUST00000071739.3 ENSMUST00000071739.4 ENSMUST00000071739.5 ENSMUST00000071739.6 ENSMUST00000071739.7 ENSMUST00000071739.8 ENSMUST00000071739.9 GSK3A_MOUSE NM_001031667 Q2NL51 uc009frx.1 uc009frx.2 uc009frx.3 Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:15791206, PubMed:17908561). Requires primed phosphorylation of the majority of its substrates (PubMed:22539723). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:15791206, PubMed:17908561). Regulates glycogen metabolism in liver, but not in muscle (PubMed:17908561). May also mediate the development of insulin resistance by regulating activation of transcription factors (By similarity). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:15791206). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (By similarity). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (PubMed:17391670). Through phosphorylation of the anti- apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (PubMed:16543145). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:22539723). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Reaction=ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl- [tau protein]; Xref=Rhea:RHEA:12801, Rhea:RHEA-COMP:13701, Rhea:RHEA- COMP:13702, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.26; Reaction=ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L- threonyl-[tau protein]; Xref=Rhea:RHEA:53904, Rhea:RHEA-COMP:13703, Rhea:RHEA-COMP:13704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.26; Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Activated by phosphorylation at Tyr-279. In response to insulin, inhibited by phosphorylation at Ser-21 by PKB/AKT1; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site. Inhibited by lithium. Monomer. Interacts with AXIN1 and CTNNB1/beta-catenin (By similarity). Interacts with ARRB2 (PubMed:16051150). Interacts with CTNND2 (By similarity). Interacts with LMBR1L (By similarity). Interacts with DDX3X (By similarity). Interacts with TNFRSF10B (By similarity). Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and deactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-279. Enhanced glucose tolerance and insulin sensitivity, increased activity of hepatic glycogen synthase, elevated hepatic glycogen storage and reduced fat mass. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. nucleotide binding regulation of systemic arterial blood pressure cardiac left ventricle morphogenesis protein kinase activity protein serine/threonine kinase activity receptor binding protein binding ATP binding nucleus cytoplasm mitochondrion cytosol microtubule carbohydrate metabolic process glycogen metabolic process regulation of gene expression by genetic imprinting protein phosphorylation signal transduction nervous system development aging insulin receptor signaling pathway negative regulation of signal transduction positive regulation of autophagy positive regulation of gene expression positive regulation of peptidyl-threonine phosphorylation Wnt signaling pathway kinase activity phosphorylation cell migration transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation protein kinase binding axon positive regulation of protein ubiquitination negative regulation of TOR signaling positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to insulin stimulus positive regulation of peptidyl-serine phosphorylation protein kinase A catalytic subunit binding cellular response to interleukin-3 proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of neuron apoptotic process hypermethylation of CpG island positive regulation of heart contraction positive regulation of transcription from RNA polymerase II promoter negative regulation of glucose import negative regulation of insulin receptor signaling pathway tau-protein kinase activity negative regulation of cell growth involved in cardiac muscle cell development regulation of microtubule cytoskeleton organization cellular response to lithium ion cellular response to organic cyclic compound positive regulation of adrenergic receptor signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway positive regulation of beta-amyloid formation regulation of mitophagy positive regulation of protein targeting to mitochondrion negative regulation of glycogen synthase activity, transferring glucose-1-phosphate negative regulation of dendrite development positive regulation of glycogen (starch) synthase activity uc009frx.1 uc009frx.2 uc009frx.3 
ENSMUST00000071750.13 Col12a1 ENSMUST00000071750.13 collagen, type XII, alpha 1 (from RefSeq NM_001290308.1) COCA1_MOUSE ENSMUST00000071750.1 ENSMUST00000071750.10 ENSMUST00000071750.11 ENSMUST00000071750.12 ENSMUST00000071750.2 ENSMUST00000071750.3 ENSMUST00000071750.4 ENSMUST00000071750.5 ENSMUST00000071750.6 ENSMUST00000071750.7 ENSMUST00000071750.8 ENSMUST00000071750.9 NM_001290308 P70322 Q60847 uc009qus.1 uc009qus.2 uc009qus.3 uc009qus.4 Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. Trimer of identical chains each containing 190 kDa of non- triple-helical sequences. Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=5; Comment=The final tissue form of collagen XII may contain homotrimers or any combination of the various isoforms.; Name=1; Synonyms=XIIA-1; IsoId=Q60847-1; Sequence=Displayed; Name=2; Synonyms=ER#K, XIIA-2; IsoId=Q60847-2; Sequence=VSP_001151, VSP_001152; Name=3; Synonyms=XIIB-1; IsoId=Q60847-3; Sequence=VSP_001150; Name=4; Synonyms=XIIB-2; IsoId=Q60847-4; Sequence=VSP_001150, VSP_001151, VSP_001152; Name=5; IsoId=Q60847-5; Sequence=VSP_023404, VSP_023405; Highest expression in tendons, perichondrium, skin, cornea, sclera, blood vessels, and periosteum. The long NC3 XIIA isoforms are predominant at early stages (ED7 and 11); at later stages of development (ED15 and 17) the short NC3 XIIB forms become the major forms. As the short NC3 forms become the major product, the long splice variant continues to be expressed in several tissues, even after birth. The long NC1 isoforms, XIIA-1 and XIIB-1, peak in 15-day old embryos and decrease in 17-day old ones. The expression of the short NC1 form XIIB-2 remains constant throughout late stages of embryonic development (ED15 and ED17). The triple-helical tail is stabilized by disulfide bonds at each end. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4- hydroxylation in vertebrates. O-glycosylation of isoform 2; glycosaminoglycan of chondroitin- sulfate type. Animals have fragile bones with a disorganized collagen fiber arrangement, decreased expression of bone matrix proteins, and decreased bone-forming activity associated with delayed terminal differentiation. They have also decreased grip strength, a delay in fiber-type transition, and a deficiency in passive force generation, while the muscle seemed more resistant to eccentric contraction-induced force drop, indicating a role for a matrix-based passive force-transducing elastic element in the generation of the weakness. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. growth plate cartilage chondrocyte morphogenesis extracellular region collagen trimer collagen type XII trimer extracellular space cell adhesion extracellular matrix structural constituent conferring tensile strength extracellular matrix endodermal cell differentiation uc009qus.1 uc009qus.2 uc009qus.3 uc009qus.4 
ENSMUST00000071760.8 Gm14496 ENSMUST00000071760.8 predicted gene 14496 (from RefSeq NM_001205282.1) ENSMUST00000071760.1 ENSMUST00000071760.2 ENSMUST00000071760.3 ENSMUST00000071760.4 ENSMUST00000071760.5 ENSMUST00000071760.6 ENSMUST00000071760.7 Gm14496 K7N5U4 K7N5U4_MOUSE NM_001205282 uc029uji.1 uc029uji.2 uc029uji.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc029uji.1 uc029uji.2 uc029uji.3 
ENSMUST00000071782.8 Nptx2 ENSMUST00000071782.8 neuronal pentraxin 2 (from RefSeq NM_016789.3) ENSMUST00000071782.1 ENSMUST00000071782.2 ENSMUST00000071782.3 ENSMUST00000071782.4 ENSMUST00000071782.5 ENSMUST00000071782.6 ENSMUST00000071782.7 NM_016789 NPTX2_MOUSE O70340 uc012egq.1 uc012egq.2 uc012egq.3 Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 calcium ions per subunit. ; Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR). Secreted extracellular region associative learning carbohydrate binding metal ion binding extrinsic component of postsynaptic specialization membrane regulation of postsynaptic neurotransmitter receptor activity glutamatergic synapse neurotransmitter receptor localization to postsynaptic specialization membrane uc012egq.1 uc012egq.2 uc012egq.3 
ENSMUST00000071792.7 1110038F14Rik ENSMUST00000071792.7 RIKEN cDNA 1110038F14 gene, transcript variant 1 (from RefSeq NM_001347540.1) CH033_MOUSE ENSMUST00000071792.1 ENSMUST00000071792.2 ENSMUST00000071792.3 ENSMUST00000071792.4 ENSMUST00000071792.5 ENSMUST00000071792.6 NM_001347540 Q3U6N9 Q3URI5 Q9D0Z5 uc007wmv.1 uc007wmv.2 uc007wmv.3 uc007wmv.4 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U6N9-1; Sequence=Displayed; Name=2; IsoId=Q3U6N9-2; Sequence=VSP_028170, VSP_028171; Name=3; IsoId=Q3U6N9-3; Sequence=VSP_028170; Belongs to the UPF0488 family. molecular_function cellular_component biological_process uc007wmv.1 uc007wmv.2 uc007wmv.3 uc007wmv.4 
ENSMUST00000071804.10 AI987944 ENSMUST00000071804.10 expressed sequence AI987944, transcript variant 1 (from RefSeq NM_183167.5) AI987944 ENSMUST00000071804.1 ENSMUST00000071804.2 ENSMUST00000071804.3 ENSMUST00000071804.4 ENSMUST00000071804.5 ENSMUST00000071804.6 ENSMUST00000071804.7 ENSMUST00000071804.8 ENSMUST00000071804.9 NM_183167 Q7TPX5 Q7TPX5_MOUSE uc009glm.1 uc009glm.2 uc009glm.3 uc009glm.4 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc009glm.1 uc009glm.2 uc009glm.3 uc009glm.4 
ENSMUST00000071812.11 Iqgap3 ENSMUST00000071812.11 IQ motif containing GTPase activating protein 3 (from RefSeq NM_001033484.1) ENSMUST00000071812.1 ENSMUST00000071812.10 ENSMUST00000071812.2 ENSMUST00000071812.3 ENSMUST00000071812.4 ENSMUST00000071812.5 ENSMUST00000071812.6 ENSMUST00000071812.7 ENSMUST00000071812.8 ENSMUST00000071812.9 F8VQ29 F8VQ29_MOUSE Iqgap3 NM_001033484 uc008pty.1 uc008pty.2 uc008pty.3 G1/S transition of mitotic cell cycle activation of MAPK activity positive regulation of protein phosphorylation protein binding calmodulin binding cytoplasm cell-cell junction signal transduction Ras protein signal transduction regulation of cell size positive regulation of gene expression negative regulation of gene expression lateral plasma membrane Ras GTPase binding Rho GTPase binding positive regulation of mammary gland epithelial cell proliferation regulation of GTPase activity ERK1 and ERK2 cascade myosin VI light chain binding cellular response to organic substance uc008pty.1 uc008pty.2 uc008pty.3 
ENSMUST00000071826.10 Crb3 ENSMUST00000071826.10 crumbs family member 3, transcript variant 3 (from RefSeq NM_001359813.1) CRUM3_MOUSE ENSMUST00000071826.1 ENSMUST00000071826.2 ENSMUST00000071826.3 ENSMUST00000071826.4 ENSMUST00000071826.5 ENSMUST00000071826.6 ENSMUST00000071826.7 ENSMUST00000071826.8 ENSMUST00000071826.9 NM_001359813 Q3TJV6 Q8QZT4 uc289meo.1 uc289meo.2 Involved in the establishment of cell polarity in mammalian epithelial cells (By similarity). Regulates the morphogenesis of tight junctions (PubMed:21145499). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (PubMed:21145499). Component of a complex composed of CRB3, PALS1 and PATJ (By similarity). Interacts (via C-terminus) with PALS1 (via PDZ domain) (PubMed:12527193). Interacts with PARD6A (By similarity). Interacts (via intracellular domain) with EPB41L5 (By similarity). Apical cell membrane ; Single-pass type I membrane protein Cell junction, tight junction Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8QZT4-1; Sequence=Displayed; Name=2; IsoId=Q8QZT4-2; Sequence=VSP_013990; Expressed in the apical renal tubules (at protein level) (PubMed:17920587). Expressed in the retinal pigment epithelium (PubMed:26404741). Expressed in the branchial arches, optic vesicle and mesonephric tubules of the kidney at 10.5 dpc (PubMed:17920587). Expressed in the internal endodermal layer and in the nascent bronchial tips of the lung at 11.5 dpc (PubMed:17920587). The PDZ-binding motif is involved in the interactions with PARD6A and PALS1. plasma membrane bicellular tight junction membrane integral component of membrane apical plasma membrane SH3 domain binding protein domain specific binding cell junction macromolecular complex apical part of cell establishment of epithelial cell apical/basal polarity cell-cell junction organization protein localization to plasma membrane uc289meo.1 uc289meo.2 
ENSMUST00000071848.7 Fmr1nb ENSMUST00000071848.7 Fmr1 neighbor, transcript variant 1 (from RefSeq NM_174993.3) B7ZNB2 B7ZNB2_MOUSE ENSMUST00000071848.1 ENSMUST00000071848.2 ENSMUST00000071848.3 ENSMUST00000071848.4 ENSMUST00000071848.5 ENSMUST00000071848.6 Fmr1nb NM_174993 uc012hjh.1 uc012hjh.2 uc012hjh.3 uc012hjh.4 membrane integral component of membrane uc012hjh.1 uc012hjh.2 uc012hjh.3 uc012hjh.4 
ENSMUST00000071852.10 Commd7 ENSMUST00000071852.10 COMM domain containing 7, transcript variant 1 (from RefSeq NM_133850.2) COMD7_MOUSE ENSMUST00000071852.1 ENSMUST00000071852.2 ENSMUST00000071852.3 ENSMUST00000071852.4 ENSMUST00000071852.5 ENSMUST00000071852.6 ENSMUST00000071852.7 ENSMUST00000071852.8 ENSMUST00000071852.9 NM_133850 Q8BG94 Q99J75 uc008nhy.1 uc008nhy.2 uc008nhy.3 uc008nhy.4 May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Associates with the NF-kappa-B complex and suppresses its transcriptional activity. Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA. Interacts with CCDC22, CCDC93, SCNN1B, CUL7. Cytoplasmic vesicle Sequence=AAH03310.1; Type=Erroneous initiation; Evidence=; cytoplasmic vesicle negative regulation of NF-kappaB transcription factor activity tumor necrosis factor-mediated signaling pathway intracellular membrane-bounded organelle negative regulation of transcription, DNA-templated NF-kappaB binding uc008nhy.1 uc008nhy.2 uc008nhy.3 uc008nhy.4 
ENSMUST00000071858.5 Hpcal1 ENSMUST00000071858.5 hippocalcin-like 1, transcript variant 1 (from RefSeq NM_016677.5) ENSMUST00000071858.1 ENSMUST00000071858.2 ENSMUST00000071858.3 ENSMUST00000071858.4 HPCL1_MOUSE NM_016677 P35333 P62748 uc007ncx.1 uc007ncx.2 uc007ncx.3 May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Membrane ; Lipid- anchor Probably binds two or three calcium ions. Belongs to the recoverin family. calcium ion binding protein binding biological_process membrane metal ion binding uc007ncx.1 uc007ncx.2 uc007ncx.3 
ENSMUST00000071873.4 Serpinb9e ENSMUST00000071873.4 serine (or cysteine) peptidase inhibitor, clade B, member 9e (from RefSeq NM_011456.3) ENSMUST00000071873.1 ENSMUST00000071873.2 ENSMUST00000071873.3 NM_011456 O08806 O08806_MOUSE Serpinb9e uc007qaf.1 uc007qaf.2 uc007qaf.3 Belongs to the serpin family. Ov-serpin subfamily. serine-type endopeptidase inhibitor activity extracellular space cytoplasm negative regulation of endopeptidase activity uc007qaf.1 uc007qaf.2 uc007qaf.3 
ENSMUST00000071874.8 Ano6 ENSMUST00000071874.8 anoctamin 6, transcript variant 2 (from RefSeq NM_175344.4) ANO6_MOUSE ENSMUST00000071874.1 ENSMUST00000071874.2 ENSMUST00000071874.3 ENSMUST00000071874.4 ENSMUST00000071874.5 ENSMUST00000071874.6 ENSMUST00000071874.7 NM_175344 Q6P9J9 Q8C242 Tmem16f uc007xju.1 uc007xju.2 uc007xju.3 uc007xju.4 Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38664; Evidence=; Reaction=a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in); Xref=Rhea:RHEA:38899, ChEBI:CHEBI:18390; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38900; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38573; Evidence=; Exhibits synergistic gating by Ca(2+) and voltage. Inhibited by some non-specific cation channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions. Homodimer. Cell membrane ; Multi-pass membrane protein Note=Shows an intracellular localization. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P9J9-1; Sequence=Displayed; Name=2; IsoId=Q6P9J9-2; Sequence=VSP_015654, VSP_015655; Predominant expression seen in epithelial tissues. Also found in skeletal system where it is primarily expressed in osteoblasts. At 14.5 dpc, expressed in lung epithelium and mesenchyme. At 16.5 dpc, expressed in esophageal epithelium and mesenchyme. In the caudal digestive tract, detected in small intestine epithelium at 14.5 dpc. Also detected at 14.5 dpc in epithelium and mesenchyme of trachea, ovary, kidney and stomach. In the developing skeleton, expressed in developing rib perichondria at 14.5 dpc. Also expressed in the neural tube and dorsal root ganglia at 14.5 dpc. In developing skin, expression is restricted to basal layers of the epidermis at 16.5 dpc. Mice are viable and fertile, and display no major morphological defects. They exhibit deficiencies in Ca(2+)-dependent phospholipid scramblase activity in platelets and defects in blood coagulation (PubMed:23021219). They also show reduced skeleton size and skeletal deformities. The term 'anoctamin' was coined because these channels are anion selective and are predicted to have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. Belongs to the anoctamin family. Contains ten transmembrane regions, not eight as predicted. dendritic cell chemotaxis activation of blood coagulation via clotting cascade calcium activated cation channel activity intracellular calcium activated chloride channel activity voltage-gated ion channel activity voltage-gated chloride channel activity chloride channel activity cytosol plasma membrane integral component of plasma membrane ion transport cation transport chloride transport lipid transport blood coagulation membrane integral component of membrane phospholipid scrambling phospholipid scramblase activity positive regulation of bone mineralization bleb assembly chloride channel complex regulation of ion transmembrane transport positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway bone mineralization involved in bone maturation sodium ion transmembrane transport protein homodimerization activity positive regulation of apoptotic process phospholipid translocation negative regulation of cell volume metal ion binding pore complex assembly protein dimerization activity positive regulation of phagocytosis, engulfment calcium activated phospholipid scrambling calcium activated phosphatidylserine scrambling calcium activated phosphatidylcholine scrambling calcium activated galactosylceramide scrambling calcium ion transmembrane transport positive regulation of monocyte chemotaxis phosphatidylserine exposure on blood platelet chloride transmembrane transport positive regulation of potassium ion export across plasma membrane positive regulation of endothelial cell apoptotic process uc007xju.1 uc007xju.2 uc007xju.3 uc007xju.4 
ENSMUST00000071876.13 Cdpf1 ENSMUST00000071876.13 cysteine rich, DPF motif domain containing 1, transcript variant 2 (from RefSeq NM_197998.2) CDPF1_MOUSE E9PUA4 ENSMUST00000071876.1 ENSMUST00000071876.10 ENSMUST00000071876.11 ENSMUST00000071876.12 ENSMUST00000071876.2 ENSMUST00000071876.3 ENSMUST00000071876.4 ENSMUST00000071876.5 ENSMUST00000071876.6 ENSMUST00000071876.7 ENSMUST00000071876.8 ENSMUST00000071876.9 NM_197998 Q8R3A2 uc007xdl.1 uc007xdl.2 uc007xdl.3 uc007xdl.4 Belongs to the CDPF1 family. molecular_function cellular_component biological_process uc007xdl.1 uc007xdl.2 uc007xdl.3 uc007xdl.4 
ENSMUST00000071880.9 Myo15a ENSMUST00000071880.9 myosin XVA, transcript variant 1 (from RefSeq NM_010862.2) A2A637 A2A638 ENSMUST00000071880.1 ENSMUST00000071880.2 ENSMUST00000071880.3 ENSMUST00000071880.4 ENSMUST00000071880.5 ENSMUST00000071880.6 ENSMUST00000071880.7 ENSMUST00000071880.8 MYO15_MOUSE Myo15 NM_010862 O70395 Q5SX93 Q7TMR5 Q7TMR6 Q9QWL6 Q9QZZ4 uc033fwa.1 uc033fwa.2 uc033fwa.3 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Required for the arrangement of stereocilia in mature hair bundles. Interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips. Interacts with FASLG (By similarity). Interacts with EPS8. Q9QZZ4; Q80VW5: Whrn; NbExp=5; IntAct=EBI-4281382, EBI-7417603; Cell projection, stereocilium Cytoplasm, cytoskeleton Note=Localizes to stereocilium tips in cochlear and vestibular hair cells. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9QZZ4-1; Sequence=Displayed; Name=2; Synonyms=1a; IsoId=Q9QZZ4-2; Sequence=VSP_029945; Name=3; Synonyms=2a; IsoId=Q9QZZ4-3; Sequence=VSP_029944, VSP_029945; In the developing inner ear, expressed in cochlea and vestibular apparatus. Expression appears to be restricted to cochlear neurosensory cells and upper epithelial layer of macula saccula. Also expressed in macula utriculi and cristae ampullaris of the semicircular canals. In adult cochlear hair cells, highest expression in stereocilia and apical body. Note=Defects in Myo15a are the cause of shaker-2 (sh-2), a condition causing deafness, circling behavior, head tossing and hyperactivity. Auditory hair cells of affected animals have very short stereocilia and a long actin-containing protrusion at their basal end. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15). nucleotide binding motor activity actin binding protein binding ATP binding cytoplasm cytoskeleton sensory perception of sound locomotory behavior myosin complex stereocilium stereocilium bundle inner ear morphogenesis cell projection uc033fwa.1 uc033fwa.2 uc033fwa.3 
ENSMUST00000071881.10 Nudt1 ENSMUST00000071881.10 nudix hydrolase 1, transcript variant 4 (from RefSeq NM_001356585.2) 8ODP_MOUSE ENSMUST00000071881.1 ENSMUST00000071881.2 ENSMUST00000071881.3 ENSMUST00000071881.4 ENSMUST00000071881.5 ENSMUST00000071881.6 ENSMUST00000071881.7 ENSMUST00000071881.8 ENSMUST00000071881.9 Mth1 NM_001356585 P53368 P97795 Q542J4 Q8VDG0 uc009aho.1 uc009aho.2 uc009aho.3 Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:11572992, PubMed:29281266, PubMed:7592783, PubMed:30304478). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (By similarity). Has also a significant hydrolase activity toward 2-oxo- ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:11572992, PubMed:29281266, PubMed:7592783, PubMed:30304478). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:11572992, PubMed:29281266, PubMed:7592783, PubMed:30304478). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:11572992, PubMed:29281266, PubMed:7592783, PubMed:30304478, PubMed:32144205). Reaction=2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+); Xref=Rhea:RHEA:31583, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:63212, ChEBI:CHEBI:77897; EC=3.6.1.56; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31584; Evidence=; Reaction=2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+); Xref=Rhea:RHEA:67392, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:71395, ChEBI:CHEBI:172878; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67393; Evidence=; Reaction=8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+); Xref=Rhea:RHEA:31575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:63224, ChEBI:CHEBI:77896; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31576; Evidence=; Reaction=8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+); Xref=Rhea:RHEA:65396, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:71361, ChEBI:CHEBI:172871; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65397; Evidence=; Reaction=H2O + O(6)-methyl-dGTP = diphosphate + H(+) + O(6)-methyl- dGMP; Xref=Rhea:RHEA:67600, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:169974, ChEBI:CHEBI:169975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67601; Evidence=; Reaction=H2O + N(6)-methyl-dATP = diphosphate + H(+) + N(6)-methyl- dAMP; Xref=Rhea:RHEA:67604, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:169976, ChEBI:CHEBI:172872; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67605; Evidence=; Reaction=H2O + N(6)-methyl-ATP = diphosphate + H(+) + N(6)-methyl-AMP; Xref=Rhea:RHEA:67608, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:144842, ChEBI:CHEBI:172873; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67609; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 Mg(2+) ion per subunit. ; Monomer. Cytoplasm Nucleus Nucleus membrane Cytoplasmic vesicle, secretory vesicle, acrosome High expression levels detected in thymus, liver, spleen, kidney, testis and large intestine, with lower levels detected in brain, heart, lung and stomach (at protein level). Expressed in kidney, liver and small intestine. Mutant mice appear normal, but have higher incidence of tumors in lung, liver and stomach. Belongs to the Nudix hydrolase family. acrosomal vesicle RNA binding GTPase activity extracellular space nucleus cytoplasm mitochondrion mitochondrial matrix cytosol plasma membrane purine nucleotide catabolic process dGTP catabolic process DNA repair aging 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity male gonad development membrane hydrolase activity snoRNA binding cytoplasmic vesicle nuclear membrane 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity GTP diphosphatase activity DNA protection dATP catabolic process response to cadmium ion metal ion binding ATP diphosphatase activity m7G(5')pppN diphosphatase activity uc009aho.1 uc009aho.2 uc009aho.3 
ENSMUST00000071885.7 Rhox8 ENSMUST00000071885.7 reproductive homeobox 8 (from RefSeq NM_001004193.3) ENSMUST00000071885.1 ENSMUST00000071885.2 ENSMUST00000071885.3 ENSMUST00000071885.4 ENSMUST00000071885.5 ENSMUST00000071885.6 NM_001004193 Q6VSS7 Q6VSS7_MOUSE Rhox8 Tox uc009szi.1 uc009szi.2 uc009szi.3 Nucleus DNA binding cellular_component nucleus biological_process uc009szi.1 uc009szi.2 uc009szi.3 
ENSMUST00000071886.7 Defa39 ENSMUST00000071886.7 defensin, alpha, 39 (from RefSeq NM_001007582.3) AY761184 Defa39 Defcr-rs1 ENSMUST00000071886.1 ENSMUST00000071886.2 ENSMUST00000071886.3 ENSMUST00000071886.4 ENSMUST00000071886.5 ENSMUST00000071886.6 NM_001007582 Q9D848 Q9D848_MOUSE uc009lbw.1 uc009lbw.2 uc009lbw.3 uc009lbw.4 Secreted innate immune response in mucosa molecular_function extracellular region extracellular space defense response response to bacterium antibacterial humoral response defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc009lbw.1 uc009lbw.2 uc009lbw.3 uc009lbw.4 
ENSMUST00000071889.13 Car12 ENSMUST00000071889.13 carbonic anhydrase 12, transcript variant 1 (from RefSeq NM_178396.5) A0A0R4J0W4 A0A0R4J0W4_MOUSE Car12 ENSMUST00000071889.1 ENSMUST00000071889.10 ENSMUST00000071889.11 ENSMUST00000071889.12 ENSMUST00000071889.2 ENSMUST00000071889.3 ENSMUST00000071889.4 ENSMUST00000071889.5 ENSMUST00000071889.6 ENSMUST00000071889.7 ENSMUST00000071889.8 ENSMUST00000071889.9 NM_178396 uc009qfc.1 uc009qfc.2 uc009qfc.3 This gene encodes a membrane-bound member of the alpha carbonic anhydrase family of enzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate. These proteins participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Reversible hydration of carbon dioxide. Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Belongs to the alpha-carbonic anhydrase family. carbonate dehydratase activity zinc ion binding membrane integral component of membrane metal ion binding chloride ion homeostasis uc009qfc.1 uc009qfc.2 uc009qfc.3 
ENSMUST00000071898.7 Cpsf1 ENSMUST00000071898.7 cleavage and polyadenylation specific factor 1, transcript variant 2 (from RefSeq NM_053193.2) CPSF1_MOUSE Cpsf160 ENSMUST00000071898.1 ENSMUST00000071898.2 ENSMUST00000071898.3 ENSMUST00000071898.4 ENSMUST00000071898.5 ENSMUST00000071898.6 NM_053193 Q9EPU4 uc007wky.1 uc007wky.2 uc007wky.3 uc007wky.4 Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3'UTR of selected pre-mRNAs (By similarity). Interacts with TENT2/GLD2. Nucleus, nucleoplasm Belongs to the CPSF1 family. nucleic acid binding RNA binding nucleus nucleoplasm mRNA cleavage and polyadenylation specificity factor complex mRNA polyadenylation mRNA processing enzyme binding mRNA 3'-UTR AU-rich region binding uc007wky.1 uc007wky.2 uc007wky.3 uc007wky.4 
ENSMUST00000071917.4 Fbxw26 ENSMUST00000071917.4 F-box and WD-40 domain protein 26 (from RefSeq NM_198674.2) EG382109 ENSMUST00000071917.1 ENSMUST00000071917.2 ENSMUST00000071917.3 Fbxw26 NM_198674 Q8BI58 Q8BI58_MOUSE uc009rsp.1 uc009rsp.2 molecular_function cellular_component biological_process uc009rsp.1 uc009rsp.2 
ENSMUST00000071921.13 Dmtf1 ENSMUST00000071921.13 cyclin D binding myb like transcription factor 1, transcript variant 16 (from RefSeq NR_189319.1) DMTF1_MOUSE Dmp1 ENSMUST00000071921.1 ENSMUST00000071921.10 ENSMUST00000071921.11 ENSMUST00000071921.12 ENSMUST00000071921.2 ENSMUST00000071921.3 ENSMUST00000071921.4 ENSMUST00000071921.5 ENSMUST00000071921.6 ENSMUST00000071921.7 ENSMUST00000071921.8 ENSMUST00000071921.9 NR_189319 P70413 Q3TUR9 Q80VR8 Q8BQX6 Q8CA56 Q8CCZ0 Q8CE22 uc008wky.1 uc008wky.2 uc008wky.3 uc008wky.4 Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53- dependent growth arrest. May also cooperate with MYB to activate transcription of the ANPEP gene. Binds to the consensus sequence 5'- CCCG[GT]ATGT-3'. Interacts with the D-type cyclins CCND1, CCND2 and CCND3. Interaction with D-type cyclins may modulate transcriptional activation by this protein. Nucleus Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8CE22-1; Sequence=Displayed; Name=2; IsoId=Q8CE22-2; Sequence=VSP_032097; Name=3; IsoId=Q8CE22-3; Sequence=VSP_032097, VSP_032100, VSP_032101; Name=4; IsoId=Q8CE22-4; Sequence=VSP_032094, VSP_032098, VSP_032099; Name=5; IsoId=Q8CE22-5; Sequence=VSP_032095, VSP_032096; Ubiquitously expressed (at mRNA level). Expressed in brain, intestine, kidney, lung, pancreas, skin, spleen and tongue (at protein level). Expressed at high levels in testis and thymus (at protein level). In all tissues examined, expression is predominant in non-proliferating and differentiated cell types. These include epithelial, interstitial and smooth muscle cells of the intestine, differentiated spermatids, sperm and interstitial cells of the testis, and lymphoid cells of the medullary compartment of the thymus. Expressed throughout the cell cycle. Expression is highest in G0 and G1 phases and decreases during S and G2/M phases. Expression is induced by activation of the Ras-Raf signaling pathway, and this may require JUN and JUNB. Expression can be repressed by E2F1, E2F2, E2F3 and E2F4. Expression is also repressed by non- classical inhibitors of NF-kappa-B signaling such as doxorubicin, daunorubicin and UVC, and by the NF-kappa-B p65 subunit (RELA). Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin- D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex. Mice spontaneously develop tumors with a mean latency around 80 weeks. The most common tumor types are pulmonary adenomas, adenocarcinomas, hepatocellular tumors, B-cell lymphomas and vascular tumors. The protein appears to be haplo-insufficient for tumor suppression, as heterozygous animals are also prone to spontaneous tumor development. Mice lacking this protein also exhibit enhanced susceptibility to tumor induction by activated Ras or the application of dimethylbenzanthracene (DMBA) or ionizing radiation. Early passage murine embryonic fibroblasts (MEFs) from animals lacking this protein are susceptible to transformation by activated Ras alone due to functional inactivation of the ARF-p53 pathway. Late passage MEFs from animals lacking this protein escape senescence without disrupting CDKN2A/ARF or p53 function. [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the DMTF1 family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus nucleoplasm cytosol cell cycle positive regulation of transcription from RNA polymerase II promoter uc008wky.1 uc008wky.2 uc008wky.3 uc008wky.4 
ENSMUST00000071926.5 Nol7 ENSMUST00000071926.5 nucleolar protein 7 (from RefSeq NM_023554.2) ENSMUST00000071926.1 ENSMUST00000071926.2 ENSMUST00000071926.3 ENSMUST00000071926.4 MNCb-1192 NM_023554 NOL7_MOUSE Q9CY79 Q9D7Z3 Q9JJE2 uc007qgc.1 uc007qgc.2 uc007qgc.3 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D7Z3-1; Sequence=Displayed; Name=2; IsoId=Q9D7Z3-2; Sequence=VSP_014793; [Isoform 2]: May be due to intron retention. Sequence=BAA95050.1; Type=Frameshift; Evidence=; nucleus nucleolus mitochondrion biological_process uc007qgc.1 uc007qgc.2 uc007qgc.3 
ENSMUST00000071937.7 Kcnj14 ENSMUST00000071937.7 potassium inwardly-rectifying channel, subfamily J, member 14 (from RefSeq NM_145963.3) ENSMUST00000071937.1 ENSMUST00000071937.2 ENSMUST00000071937.3 ENSMUST00000071937.4 ENSMUST00000071937.5 ENSMUST00000071937.6 Irk4 KCJ14_MOUSE NM_145963 Q8BMK3 Q8BXM0 Q8JZN3 uc009gxi.1 uc009gxi.2 uc009gxi.3 Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity). Membrane; Multi-pass membrane protein. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily. inward rectifier potassium channel activity voltage-gated ion channel activity ion transport potassium ion transport membrane integral component of membrane dendrite regulation of ion transmembrane transport neuronal cell body potassium ion import across plasma membrane uc009gxi.1 uc009gxi.2 uc009gxi.3 
ENSMUST00000071949.5 Bloc1s4 ENSMUST00000071949.5 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino (from RefSeq NM_133724.3) BL1S4_MOUSE Cno ENSMUST00000071949.1 ENSMUST00000071949.2 ENSMUST00000071949.3 ENSMUST00000071949.4 NM_133724 Q8VED2 uc008xez.1 uc008xez.2 uc008xez.3 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8 (By similarity). Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. Interacts with BLOC1S5 and BLOC1S6. Cytoplasm Widely expressed. Note=Defects in Cno are the cause of the cappuccino (Cno) mutant, which is characterized by a severe oculocutaneous albinism due to abnormal melanosome formation, and prolonged bleeding due to deficiency of platelet dense body contents. Belongs to the BLOC1S4 family. protein binding cytoplasm anterograde axonal transport BLOC-1 complex neuron projection development melanosome organization anterograde synaptic vesicle transport neuromuscular process controlling balance platelet aggregation axon cytoplasm uc008xez.1 uc008xez.2 uc008xez.3 
ENSMUST00000071951.14 H2-Q7 ENSMUST00000071951.14 histocompatibility 2, Q region locus 7, transcript variant 1 (from RefSeq NM_010394.4) ENSMUST00000071951.1 ENSMUST00000071951.10 ENSMUST00000071951.11 ENSMUST00000071951.12 ENSMUST00000071951.13 ENSMUST00000071951.2 ENSMUST00000071951.3 ENSMUST00000071951.4 ENSMUST00000071951.5 ENSMUST00000071951.6 ENSMUST00000071951.7 ENSMUST00000071951.8 ENSMUST00000071951.9 HA17_MOUSE NM_010394 P14429 uc008chs.1 uc008chs.2 uc008chs.3 uc008chs.4 Involved in the presentation of foreign antigens to the immune system. Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Membrane; Single-pass type I membrane protein. Belongs to the MHC class I family. Sequence=CAA28977.1; Type=Erroneous initiation; Evidence=; positive regulation of T cell mediated cytotoxicity immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response embryo implantation external side of plasma membrane cell surface membrane integral component of membrane phagocytic vesicle membrane beta-2-microglobulin binding peptide binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex TAP binding protein heterodimerization activity endoplasmic reticulum exit site cellular response to interferon-gamma integral component of lumenal side of endoplasmic reticulum membrane uc008chs.1 uc008chs.2 uc008chs.3 uc008chs.4 
ENSMUST00000071968.9 Trpv4 ENSMUST00000071968.9 transient receptor potential cation channel, subfamily V, member 4 (from RefSeq NM_022017.3) A0JNY0 ENSMUST00000071968.1 ENSMUST00000071968.2 ENSMUST00000071968.3 ENSMUST00000071968.4 ENSMUST00000071968.5 ENSMUST00000071968.6 ENSMUST00000071968.7 ENSMUST00000071968.8 NM_022017 Q91XR5 Q9EPK8 Q9EQZ4 Q9ERZ7 Q9ES76 TRPV4_MOUSE Trp12 Vrl2 Vroac uc008yzv.1 uc008yzv.2 uc008yzv.3 uc008yzv.4 Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11094154). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:12093812, PubMed:14691263, PubMed:16368742, PubMed:16571723). Also activated by heat, low pH, citrate and phorbol esters (PubMed:14691263). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (By similarity). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4- alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (By similarity). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (PubMed:20413591). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (PubMed:23021218). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (PubMed:23021218). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Required for normal development and maintenance of bone and cartilage (By similarity). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (By similarity). Homotetramer. Interacts with calmodulin (By similarity). Interacts with CTNNB1 (PubMed:20413591). The TRPV4 and CTNNB1 complex can interact with CDH1 (PubMed:20413591). Part of a complex containing MLC1, AQP4, HEPACAM and ATP1B1 (By similarity). Interacts with MAP7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES (PubMed:14517216, PubMed:12538589). Interacts with PACSIN1, PACSIN2 and PACSIN3 (via SH3 domain) (PubMed:16627472, PubMed:18174177). Interacts with ITPR3 (By similarity). Interacts with AQP5; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity (PubMed:16571723). Interacts with ANO1 (PubMed:24509911). Interacts (via C-terminus) with PKD2 (via C-terminus) (PubMed:18695040). Interacts with DDX3X; this interaction is decreased when the channel is activated (By similarity). Q9EPK8; P55088: Aqp4; NbExp=2; IntAct=EBI-7091763, EBI-6273066; Q9EPK8; Q13563: PKD2; Xeno; NbExp=11; IntAct=EBI-7091763, EBI-7813714; Q9EPK8; P48995: TRPC1; Xeno; NbExp=10; IntAct=EBI-7091763, EBI-929665; Q9EPK8; P0CG48: UBC; Xeno; NbExp=3; IntAct=EBI-7091763, EBI-3390054; Cell membrane Apical cell membrane ulti-pass membrane protein Cell junction, adherens junction Cell projection, cilium Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. Localization to the cell membrane is inhibited by WNK kinases (WNK1, WNK2, WNK3 or WNK4) in a kinase-independent mechanism. Detected in liver, kidney, heart, brain cortex, cerebellum and brainstem (at protein level). Expressed in salivary glands (at protein level) (PubMed:16571723). Expressed in heart, lung, spleen, liver, kidney, brain, skeletal muscle and testis. In the central nervous system, expressed in the lamina terminalis (arched vascular organ and neurons of the subfornical organ), median preoptic area, ventral hippocampal commissure, and ependymal cells of the choroid plexus. In the cochlea, expressed in both inner and outer hair cells, and in marginal cells of the cochlear stria vascularis. Expressed in large neurons of the trigeminal ganglion. In the kidney cortex, strongly expressed by epithelial cells of tubules and much weaker in glomeruli. The ANK repeat region mediates interaction with Ca(2+)- calmodulin and ATP binding. The ANK repeat region mediates interaction with phosphatidylinositol-4,5-bisphosphate and related phosphatidylinositides. N-glycosylated. Mice display impairment of the intercellular junction-dependent barrier function in the skin (PubMed:20413591). Increased energy expenditure and improved insulin sensitivity in white adipose tissues (PubMed:23021218). Reduced Ca2+ entry and loss of regulatory volume decrease in response to hypotonicity in acinar cells (PubMed:16571723). Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily. Sequence=AAG28028.1; Type=Frameshift; Evidence=; Sequence=AAK69486.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleotide binding diet induced thermogenesis actin binding osmosensor activity protein kinase C binding ion channel activity cation channel activity calcium channel activity protein binding calmodulin binding ATP binding cytoplasmic microtubule plasma membrane integral component of plasma membrane adherens junction focal adhesion cilium ion transport calcium ion transport cellular calcium ion homeostasis response to osmotic stress hypotonic response actin filament organization cell-cell junction assembly positive regulation of cytosolic calcium ion concentration osmosensory signaling pathway microtubule binding lipid binding cell surface positive regulation of gene expression positive regulation of macrophage chemotaxis negative regulation of neuron projection development stretch-activated, cation-selective, calcium channel activity membrane integral component of membrane apical plasma membrane protein kinase binding lamellipodium cell junction vasopressin secretion filopodium growth cone cortical actin cytoskeleton positive regulation of microtubule depolymerization cytoplasmic vesicle actin cytoskeleton reorganization ruffle membrane response to insulin cellular response to heat SH2 domain binding hyperosmotic salinity response glucose homeostasis identical protein binding cell projection alpha-tubulin binding positive regulation of vascular permeability cortical microtubule organization positive regulation of JNK cascade microtubule polymerization metal ion binding regulation of response to osmotic stress beta-tubulin binding positive regulation of inflammatory response multicellular organismal water homeostasis actin filament binding transmembrane transport cartilage development involved in endochondral bone morphogenesis positive regulation of ERK1 and ERK2 cascade calcium ion import calcium ion transmembrane transport cellular response to osmotic stress cellular hypotonic response cellular hypotonic salinity response positive regulation of monocyte chemotactic protein-1 production positive regulation of macrophage inflammatory protein 1 alpha production positive regulation of chemokine (C-C motif) ligand 5 production energy homeostasis blood vessel endothelial cell delamination negative regulation of brown fat cell differentiation signal transduction involved in regulation of aerobic respiration positive regulation of chemokine (C-X-C motif) ligand 1 production positive regulation of interleukin-6 secretion response to lipopolysaccharide response to fatty acid regulation of p38MAPK cascade uc008yzv.1 uc008yzv.2 uc008yzv.3 uc008yzv.4 
ENSMUST00000071972.11 Cfap57 ENSMUST00000071972.11 cilia and flagella associated protein 57 (from RefSeq NM_026789.5) A2ACY9 CFA57_MOUSE Cfap57 ENSMUST00000071972.1 ENSMUST00000071972.10 ENSMUST00000071972.2 ENSMUST00000071972.3 ENSMUST00000071972.4 ENSMUST00000071972.5 ENSMUST00000071972.6 ENSMUST00000071972.7 ENSMUST00000071972.8 ENSMUST00000071972.9 NM_026789 Q9D180 Wdr65 uc012dkc.1 uc012dkc.2 uc012dkc.3 uc012dkc.4 Predominanly expressed in testis, lung and skin. Weak expression in brain and kidney. Expression in the palate increases from 12.5 up to 15.5 dpc. At 14.5, detected in the nasal epithelium and detected in the medial edge epithelium. At 15.5 dpc, very strong expression in the nasal respiratory epithelium and epidermis, but not in the oral epithelium. In the nasal epithelium, limited to the respiratory, but not the olfactory, epithelium. Sequence=AAH62805.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB23034.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function uc012dkc.1 uc012dkc.2 uc012dkc.3 uc012dkc.4 
ENSMUST00000071973.8 Ero1b ENSMUST00000071973.8 endoplasmic reticulum oxidoreductase 1 beta, transcript variant 2 (from RefSeq NM_026184.3) ENSMUST00000071973.1 ENSMUST00000071973.2 ENSMUST00000071973.3 ENSMUST00000071973.4 ENSMUST00000071973.5 ENSMUST00000071973.6 ENSMUST00000071973.7 ERO1B_MOUSE Ero1b Ero1lb NM_026184 Q14DN0 Q8R2E9 uc007pls.1 uc007pls.2 Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2, PDIA3, PDIA4, PDIA6 and NXNDC12. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity). Involved in oxidative proinsulin folding in pancreatic cells, hence required for glucose homeostasis in vivo. Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Glutathione may be required to regulate its activity in the endoplasmic reticulum. Homodimer; disulfide-linked (By similarity). Heterodimer with ERO1A; disulfide-linked (By similarity). Also detected as monomer. Homodimers may be somewhat less active than monomers. The abundance of monomers and homodimers may be tissue-specific. Interacts with P4HB (By similarity). Interacts with ERP44 (By similarity). Endoplasmic reticulum membrane ; Peripheral membrane protein ; Lumenal side Note=The association with ERP44 may be essential for its retention in the endoplasmic reticulum. Predominantly expressed in stomach and pancreas (mostly in the islets of Langerhans) (at protein level). N-glycosylated. The Cys-90/Cys-95 and Cys-393/Cys-396 disulfide bonds constitute the redox-active center. The Cys-90/Cys-95 disulfide bond may accept electron from P4HB and funnel them to the active site disulfide Cys- 393/Cys-396 (By similarity). Belongs to the EROs family. protein disulfide isomerase activity endoplasmic reticulum endoplasmic reticulum membrane protein disulfide oxidoreductase activity membrane oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor 4-hydroxyproline metabolic process protein maturation by protein folding insulin processing extracellular matrix organization protein folding in endoplasmic reticulum glucose homeostasis cell redox homeostasis oxidation-reduction process uc007pls.1 uc007pls.2 
ENSMUST00000071979.2 Or10ak8 ENSMUST00000071979.2 olfactory receptor family 10 subfamily AK member 8 (from RefSeq NM_001011870.2) ENSMUST00000071979.1 L7MTV4 L7MTV4_MOUSE NM_001011870 Olfr1329 Or10ak8 uc008ula.1 uc008ula.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008ula.1 uc008ula.2 
ENSMUST00000071982.7 Bmper ENSMUST00000071982.7 BMP-binding endothelial regulator (from RefSeq NM_028472.2) BMPER_MOUSE Cv2 ENSMUST00000071982.1 ENSMUST00000071982.2 ENSMUST00000071982.3 ENSMUST00000071982.4 ENSMUST00000071982.5 ENSMUST00000071982.6 NM_028472 Q7TN57 Q80UZ1 Q8CJ69 Q9CXM8 uc009oow.1 uc009oow.2 uc009oow.3 uc009oow.4 This gene encodes a secreted protein that contains five Von Willebrand factor type C domains and a Von Willebrand factor type D domain and a trypsin inhibitory-like domain. The encoded protein binds to bone morphogenetic proteins (BMP) and regulates their activity. Mutation of the related gene in humans causes diaphanospondylodysostosis. [provided by RefSeq, Mar 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF454954.1, AY263358.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. Interacts with BMP4. Secreted At 9.0 dpc, expressed in the ventral tail bud and also in the closing anterior neuropore and in the roof of the neural tube, at 10.5 dpc, also expressed in mesonephric ridge. ureteric bud development blood vessel endothelial cell proliferation involved in sprouting angiogenesis extracellular matrix structural constituent protein binding extracellular region extracellular space regulation of endothelial cell migration negative regulation of BMP signaling pathway endothelial cell activation inner ear development regulation of pathway-restricted SMAD protein phosphorylation positive regulation of ERK1 and ERK2 cascade positive regulation of sprouting angiogenesis uc009oow.1 uc009oow.2 uc009oow.3 uc009oow.4 
ENSMUST00000071985.6 Slco4c1 ENSMUST00000071985.6 solute carrier organic anion transporter family, member 4C1 (from RefSeq NM_172658.3) ENSMUST00000071985.1 ENSMUST00000071985.2 ENSMUST00000071985.3 ENSMUST00000071985.4 ENSMUST00000071985.5 NM_172658 Oatp4c1 Q8BGD4 SO4C1_MOUSE Slc21a20 Slco4c1 uc007cfc.1 uc007cfc.2 uc007cfc.3 Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney. Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate. Transport is independent of sodium, chloride ion, and ATP. Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (By similarity). The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (By similarity). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)- dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (By similarity). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (PubMed:16641146). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (PubMed:16641146). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (PubMed:16641146). Reaction=estrone 3-sulfate(out) = estrone 3-sulfate(in); Xref=Rhea:RHEA:71835, ChEBI:CHEBI:60050; Evidence=; Reaction=L-thyroxine(out) = L-thyroxine(in); Xref=Rhea:RHEA:71819, ChEBI:CHEBI:58448; Evidence=; Reaction=3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L- thyronine(in); Xref=Rhea:RHEA:71811, ChEBI:CHEBI:533015; Evidence=; Reaction=chenodeoxycholate(out) = chenodeoxycholate(in); Xref=Rhea:RHEA:75051, ChEBI:CHEBI:36234; Evidence=; Reaction=glycocholate(out) = glycocholate(in); Xref=Rhea:RHEA:71851, ChEBI:CHEBI:29746; Evidence=; Reaction=L-homoarginine(in) = L-homoarginine(out); Xref=Rhea:RHEA:71203, ChEBI:CHEBI:143006; Evidence=; Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143, ChEBI:CHEBI:32682; Evidence=; Reaction=N(omega),N(omega)-dimethyl-L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(in); Xref=Rhea:RHEA:75047, ChEBI:CHEBI:58326; Evidence=; Basolateral cell membrane ; Multi-pass membrane protein Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney. Strongly expressed in initial segment of epididymis and seminal vesicles. Dramatically down-regulated 1 day after gonadectomy. Belongs to the organo anion transporter (TC 2.A.60) family. plasma membrane integral component of plasma membrane ion transport multicellular organism development spermatogenesis organic anion transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity organic anion transport membrane integral component of membrane basolateral plasma membrane cell differentiation sodium-independent organic anion transport transmembrane transport uc007cfc.1 uc007cfc.2 uc007cfc.3 
ENSMUST00000071986.13 Mia ENSMUST00000071986.13 MIA SH3 domain containing (from RefSeq NM_019394.3) Cdrap ENSMUST00000071986.1 ENSMUST00000071986.10 ENSMUST00000071986.11 ENSMUST00000071986.12 ENSMUST00000071986.2 ENSMUST00000071986.3 ENSMUST00000071986.4 ENSMUST00000071986.5 ENSMUST00000071986.6 ENSMUST00000071986.7 ENSMUST00000071986.8 ENSMUST00000071986.9 MIA_MOUSE Mia1 NM_019394 O09086 P97495 Q61865 uc009fvf.1 uc009fvf.2 uc009fvf.3 uc009fvf.4 Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas. Interacts with FASLG. Secreted. All malignant melanoma cell lines tested and infrequently in glioma cell lines. May possess two intramolecular disulfide bonds. Belongs to the MIA/OTOR family. extracellular region cell-matrix adhesion signal transduction growth factor activity extracellular matrix organization uc009fvf.1 uc009fvf.2 uc009fvf.3 uc009fvf.4 
ENSMUST00000071991.6 Dppa5a ENSMUST00000071991.6 developmental pluripotency associated 5A (from RefSeq NM_025274.3) DPA5A_MOUSE Dppa5 ENSMUST00000071991.1 ENSMUST00000071991.2 ENSMUST00000071991.3 ENSMUST00000071991.4 ENSMUST00000071991.5 Ecat2 Esg1 NM_025274 Ph34 Q9CQS7 uc009qug.1 uc009qug.2 uc009qug.3 uc009qug.4 uc009qug.5 Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs. Cytoplasm Pluripotent cell-specific. Expressed in zygotes, cleavage-stage embryos and blastocysts, embryonic stem (ES) and embryonic germ (EG) cells. Detected in both the trophectoderm (TE) and inner cell mass (ICM) of blastocysts. More abundant in the ICM than TE at 3.5 dpc blastocyst stage. Expressed in primordial germ (PGC) cells from 10.5 to 13.5 dpc. Expressed in developing gonads from 11.5 to 15.5 dpc. Progressively undetectable in ovary from 13.5 to 15.5 dpc. Undetectable in testis after 15.5 dpc. Not expressed in somatic cells at 13.5 dpc (at protein level). Expressed in embryonic stem (ES) and embryonic carcinoma (EC) cells. Not detected during the differentiation of stem cells or midgestation embryos nor in neonatal tissues. Weakly expressed or not detected in oocytes and fertilized eggs. Down-regulated by retinoic acid in embryonic carcinoma (EC) cells and in developing germ cells. Mice develop normally and are fertile. ES cells derived from these mice demonstrate normal morphology, proliferation and differentiation. Belongs to the KHDC1 family. RNA binding mRNA binding cytoplasm multicellular organism development regulation of gene expression uc009qug.1 uc009qug.2 uc009qug.3 uc009qug.4 uc009qug.5 
ENSMUST00000072008.11 Sh3rf2 ENSMUST00000072008.11 SH3 domain containing ring finger 2, transcript variant 1 (from RefSeq NM_001146299.1) B2RQJ2 ENSMUST00000072008.1 ENSMUST00000072008.10 ENSMUST00000072008.2 ENSMUST00000072008.3 ENSMUST00000072008.4 ENSMUST00000072008.5 ENSMUST00000072008.6 ENSMUST00000072008.7 ENSMUST00000072008.8 ENSMUST00000072008.9 NM_001146299 Posh3 Ppp1r39 Q80VJ1 Q8BZT2 Q8C122 Q8C1E3 Rnf158 SH3R2_MOUSE uc008etl.1 uc008etl.2 uc008etl.3 uc008etl.4 Has E3 ubiquitin-protein ligase activity. Acts as an anti- apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro- apoptotic JNK activation. Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with FASLG and PPP1CA. Interacts with PAK4 and TNFRSF1A. Interacts with DLK1, MAP3K10, MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3. Interacts with RAC1 (both active GTP- or inactive GDP-bound forms). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZT2-1; Sequence=Displayed; Name=2; IsoId=Q8BZT2-2; Sequence=VSP_022060; The RING finger domain is required for ubiquitin ligase activity and autoubiquitination. Autoubiquitinated. Belongs to the SH3RF family. protein phosphatase inhibitor activity nucleus nucleoplasm protein phosphatase 1 binding negative regulation of phosphatase activity protein ubiquitination transferase activity phosphatase binding positive regulation of cell migration negative regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of phosphoprotein phosphatase activity negative regulation of apoptotic process regulation of JNK cascade negative regulation of JNK cascade positive regulation of JNK cascade metal ion binding protein autoubiquitination ubiquitin protein ligase activity uc008etl.1 uc008etl.2 uc008etl.3 uc008etl.4 
ENSMUST00000072018.6 Alms1 ENSMUST00000072018.6 ALMS1, centrosome and basal body associated (from RefSeq NM_145223.2) ALMS1_MOUSE E9QKT8 ENSMUST00000072018.1 ENSMUST00000072018.2 ENSMUST00000072018.3 ENSMUST00000072018.4 ENSMUST00000072018.5 Kiaa0328 NM_145223 Q6A084 Q8C9N9 Q8K4E0 uc009cpz.1 uc009cpz.2 uc009cpz.3 Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells (By similarity). Q8K4E0; Q7TPR4: Actn1; NbExp=4; IntAct=EBI-6272972, EBI-774010; Q8K4E0; P57780: Actn4; NbExp=4; IntAct=EBI-6272972, EBI-445071; Q8K4E0; Q9D753: Exosc8; NbExp=3; IntAct=EBI-6272972, EBI-8387079; Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, spindle pole Note=Associated with centrosomes and basal bodies at the base of primary cilia. Specifically locates to the proximal ends of centrioles and basal bodies. Colocalizes partially with NCAPD2 at these sites. During mitosis localizes to both spindle poles (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K4E0-1; Sequence=Displayed; Name=2; IsoId=Q8K4E0-2; Sequence=VSP_017350; Ubiquitously expressed. Expressed at 7.5 dpc. At 8.0 dpc expression is found in mesodermal- and ectodermal-derived layers. At 10.5 dpc mainly detected in midbrain, hindbrain, forelimb and hindlimb. Also expressed at 15.5 dpc and 18.5 dpc. Mice display obesity, hypogonadism, hyperinsulinemia, retinal dysfunction and hearing loss. Belongs to the ALMS1 family. Sequence=BAD32212.1; Type=Erroneous initiation; Evidence=; spindle pole cellular glucose homeostasis establishment of planar polarity cytoplasm centrosome centriole microtubule organizing center cytosol cytoskeleton cilium lipid metabolic process spermatid development sensory perception of sound microtubule binding endosomal transport calcium-mediated signaling ovulation ciliary basal body negative regulation of multicellular organism growth glucose homeostasis cholesterol homeostasis cell projection negative regulation of apoptotic process regulation of fat cell differentiation retinal rod cell development regulation of centriole replication epithelial cell proliferation alpha-actinin binding regulation of stress fiber assembly inner ear receptor stereocilium organization cilium assembly uc009cpz.1 uc009cpz.2 uc009cpz.3 
ENSMUST00000072020.9 Tle6 ENSMUST00000072020.9 transducin-like enhancer of split 6, transcript variant 1 (from RefSeq NM_053254.2) ENSMUST00000072020.1 ENSMUST00000072020.2 ENSMUST00000072020.3 ENSMUST00000072020.4 ENSMUST00000072020.5 ENSMUST00000072020.6 ENSMUST00000072020.7 ENSMUST00000072020.8 Grg6 NM_053254 Q9WVB3 TLE6_MOUSE uc007giu.1 uc007giu.2 As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:18804437, PubMed:25208553). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (PubMed:31575650). Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (PubMed:32823735). Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (PubMed:16314515). Acts as a transcriptional corepressor of NFATC1- mediated gene expression by contributing to PAX6-mediated repression (PubMed:23990468). Homodimers (PubMed:16314515). Component of the subcortical maternal complex (SCMC), at least composed of NLRP5, KHDC3, OOEP, and TLE6 (PubMed:18804437, PubMed:28992324). Within the complex, interacts with NLRP5, KHDC3 and OOEP (PubMed:28992324, PubMed:31575650). The SCMC may facilitate translocation of its components between the nuclear and cytoplasmic compartments (By similarity). As part of the SCMC interacts with the SCMC-associated protein ZBED3 (PubMed:31575650). As part of the SCMC interacts with the SCMC-associated protein NLRP4F (PubMed:31575650). As part of the SCMC interacts with the SCMC- associated protein CFL1/Cofilin-1 (PubMed:25208553). Interacts with FOXG1/BF-1; the interaction inhibits TLE1 interaction with FOXG1/BF-1 (PubMed:16314515). Interacts with NFATC1 (PubMed:23990468). Interacts with PAX6 (PubMed:23990468). Cytoplasm cleus Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages (PubMed:18804437, PubMed:25208553). At the 2-cell and morular stage, still detected in the subcortex, but excluded from cell-cell contact regions (PubMed:18804437, PubMed:25208553). Expression largely disappears in blastocysts (PubMed:25208553). Expressed in spermatogonia (at protein level) (PubMed:32823735). Expressed predominantly in ovaries, where it is restricted to growing oocytes, with greatest levels in fully grown oocytes (PubMed:18804437, PubMed:25208553). Expressed predominantly in testis, heart, lung, liver and muscle, and at very low levels in the brain, spleen and kidney (PubMed:11486032). Expressed in bone marrow- derived macrophages and osteoclasts (PubMed:23990468). Transcripts first detected at 15.5 dpc and peak 1 week after birth. Transcripts accumulate during oogenesis (PubMed:18804437). During meiotic maturation, the vast majority of the transcripts are degraded and virtually none is detected by 2-cell stage embryogenesis (PubMed:18804437). The protein however persists during preimplantation up to the blastocyst stage (PubMed:18804437). At 2-cell stage, excluded from cell-cell contact regions. Continuous exclusion from these regions during preimplantation development leads to the absence of the protein from the inner cells of the morula and the inner cell mass of the blastocyst (PubMed:18804437). Expressed in the forebrain, midbrain, ventricular zone and superficial cortical plate at 14.5 dpc (PubMed:16314515). Expressed in cortical progenitors in the forebrain dorsal telencephalon and the midbrain at 15.5 dpc (PubMed:16314515). Expressed in ovaries at postnatal day 2 (P2), expression peaks at P10, expression is then decreased at P17 and further decreased at P21 (PubMed:31575650). Induced by E2A-HLF, a chimeric transcription factor containing the transactivation domain of E2A linked to the DNA-binding and dimerization domain of HLF (PubMed:11486032). Induced during TNFSF11/RANKL-induced osteoclast differentiation (PubMed:23990468). Contrary to other WD repeat Groucho/TLE family members, does not contain any identifiable Q, GP, CcN or SP domains. Only the C- terminal WD-repeat domain is conserved. Females show normal ovarian histology, ovulation and egg morphology, however fail to produce offspring following successful mating (PubMed:25208553). Progression from one- to two-cell embryos is delayed by 4-6 hours and embryos failed to develop into morulae and blastocysts (PubMed:25208553). Embryos form unequal sized blastomeres due to smaller, dysmorphic, and displaced mitotic spindles resulting to asymmetric division (PubMed:25208553). Loss of FMN2- expressing endoplasmic reticulum localization to the mitotic spindle periphery, and incorrect localization of mitochondria to the subcortical region prior to nuclear envelope breakdown in zygotes and oocytes (PubMed:28992324). Extension of the alpha-tubulin pool into the subcortical region following microtubule-organizing center congression in oocytes (PubMed:28992324). Decrease in expression of the SCMC components ZBED3, NLRP5/MATER, KHDC3/FILIA and OOEP/FLOPED in oocytes (PubMed:25208553, PubMed:28992324). Loss of F-actin cytoplasmic lattices in oocytes, zygotes and embryos (PubMed:25208553, PubMed:31575650). Decrease in thickness of subcortical F-actin in zygotes and thickening of F-actin bundles in the cytoplasm is evident (PubMed:25208553). Decrease in CFL1/Cofilin-1 expression in the subcortex, diffused distribution in the cytoplasm of zygotes and decrease in phosphorylated CFL1/Cofilin-1 expression in oocytes and zygotes (PubMed:25208553). Belongs to the WD repeat Groucho/TLE family. transcription corepressor activity protein binding nucleus transcription factor complex cytoplasm cytosol cell cortex regulation of transcription, DNA-templated macromolecular complex positive regulation of neuron differentiation positive regulation of neurogenesis embryonic process involved in female pregnancy repressing transcription factor binding negative regulation of canonical Wnt signaling pathway negative regulation of nucleic acid-templated transcription uc007giu.1 uc007giu.2 
ENSMUST00000072031.13 Mprip ENSMUST00000072031.13 myosin phosphatase Rho interacting protein, transcript variant 1 (from RefSeq NM_201245.3) ENSMUST00000072031.1 ENSMUST00000072031.10 ENSMUST00000072031.11 ENSMUST00000072031.12 ENSMUST00000072031.2 ENSMUST00000072031.3 ENSMUST00000072031.4 ENSMUST00000072031.5 ENSMUST00000072031.6 ENSMUST00000072031.7 ENSMUST00000072031.8 ENSMUST00000072031.9 Kiaa0864 MPRIP_MOUSE Mrip NM_201245 P97434 Q3TBR5 Q3TC85 Q3TRS0 Q3U1Y8 Q3U3E4 Q5SWZ3 Q5SWZ4 Q5SWZ7 Q6P559 Q80YC8 Rhoip3 uc007jeo.1 uc007jeo.2 uc007jeo.3 Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin- binding region leads to disassembly of stress fibers in neuronal cells. Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains. Interacts with MYZAP. Binds F-actin through its N- terminus. Cytoplasm, cytoskeleton Note=Colocalizes with F-actin. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P97434-1; Sequence=Displayed; Name=2; IsoId=P97434-2; Sequence=VSP_017293; Name=3; IsoId=P97434-3; Sequence=VSP_017292, VSP_017293; Name=4; IsoId=P97434-4; Sequence=VSP_017290; Name=5; IsoId=P97434-5; Sequence=VSP_017291; Expressed in Kidney, Brain, Heart and Lung. Sequence=BAE36957.1; Type=Erroneous initiation; Evidence=; stress fiber positive regulation of protein phosphorylation actin binding cytoplasm cytosol cytoskeleton actin cytoskeleton maintenance of protein location in cell negative regulation of myosin-light-chain-phosphatase activity uc007jeo.1 uc007jeo.2 uc007jeo.3 
ENSMUST00000072035.4 Or5p62 ENSMUST00000072035.4 olfactory receptor family 5 subfamily P member 62 (from RefSeq NM_146496.1) ENSMUST00000072035.1 ENSMUST00000072035.2 ENSMUST00000072035.3 Mor204-19 NM_146496 O5P62_MOUSE Olfr486 Or5p62 Q8VFD0 uc009jcb.1 uc009jcb.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jcb.1 uc009jcb.2 
ENSMUST00000072040.7 Vrk1 ENSMUST00000072040.7 vaccinia related kinase 1, transcript variant 7 (from RefSeq NM_001422980.1) ENSMUST00000072040.1 ENSMUST00000072040.2 ENSMUST00000072040.3 ENSMUST00000072040.4 ENSMUST00000072040.5 ENSMUST00000072040.6 NM_001422980 O88635 O88636 Q80X41 Q8C2P7 Q91YH9 VRK1_MOUSE Vrk1 uc007ozd.1 uc007ozd.2 uc007ozd.3 Serine/threonine kinase involved in cell cycle, nuclear condensation and transcription regulation (PubMed:14645249, PubMed:9521809, PubMed:33076429). Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation (By similarity). Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2 (By similarity). Phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity (PubMed:33076429). Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain- containing proteins and causes its relocalization from the nucleus to the cytoplasm (By similarity). Phosphorylates ATF2 which activates its transcriptional activity (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Active in presence of Mn(2+), Mg(2+) and Zn(2+), but is not functional with Ca(2+) or Cu(2+). Has a higher affinity for Mn(2+) than for Mg(2+). RAN inhibits its autophosphorylation and its ability to phosphorylate histone H3 (By similarity). Nucleus toplasm Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=L; IsoId=Q80X41-1; Sequence=Displayed; Name=2; IsoId=Q80X41-2; Sequence=VSP_008529; Name=3; Synonyms=S; IsoId=Q80X41-3; Sequence=VSP_008532; Name=5; IsoId=Q80X41-5; Sequence=VSP_008528, VSP_008532; Highly expressed in testis. Expressed in liver, kidney and muscle. Weakly expressed in thymus, bone marrow and spleen. Expressed from 10.5 dpc to 14 dpc in developing liver and then decreases. It increases again from 17.5 dpc and remains thereafter. Highly expressed in hematopoietic embryonic tissues from 10.5 dpc to 14.5 dpc. Weakly expressed in the yolk-sac. Autophosphorylated at various serine and threonine residues (PubMed:14645249). Autophosphorylation does not impair its ability to phosphorylate p53/TP53 (By similarity). Phosphorylation by PLK3 leads to induction of Golgi fragmentation during mitosis (By similarity). Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleoplasm nucleolus cytoplasm Golgi stack spindle cytosol cytoskeleton protein phosphorylation cell cycle kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation protein kinase binding nucleosomal histone binding histone kinase activity (H3-S10 specific) histone H3-S10 phosphorylation protein autophosphorylation cell division histone kinase activity (H3-T3 specific) histone H3-T3 phosphorylation Golgi disassembly uc007ozd.1 uc007ozd.2 uc007ozd.3 
ENSMUST00000072055.13 Chka ENSMUST00000072055.13 choline kinase alpha, transcript variant 1 (from RefSeq NM_013490.5) CHKA_MOUSE Chk ENSMUST00000072055.1 ENSMUST00000072055.10 ENSMUST00000072055.11 ENSMUST00000072055.12 ENSMUST00000072055.2 ENSMUST00000072055.3 ENSMUST00000072055.4 ENSMUST00000072055.5 ENSMUST00000072055.6 ENSMUST00000072055.7 ENSMUST00000072055.8 ENSMUST00000072055.9 G5E853 NM_013490 O54804 Q8BPL3 Q8BPW6 Q9CXP3 Q9QX56 uc008fxg.1 uc008fxg.2 uc008fxg.3 uc008fxg.4 Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis. Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis. Has higher activity with choline. May contribute to tumor cell growth. [Isoform 1]: This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation (By similarity). In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets (By similarity). Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer (By similarity). Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets (By similarity). Reaction=ATP + choline = ADP + H(+) + phosphocholine; Xref=Rhea:RHEA:12837, ChEBI:CHEBI:15354, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:295975, ChEBI:CHEBI:456216; EC=2.7.1.32; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12838; Evidence=; Reaction=ATP + ethanolamine = ADP + H(+) + phosphoethanolamine; Xref=Rhea:RHEA:13069, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57603, ChEBI:CHEBI:58190, ChEBI:CHEBI:456216; EC=2.7.1.82; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13070; Evidence=; [Isoform 1]: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10597; Evidence=; Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1. Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. Homodimer (PubMed:16490392). Heterodimer with CHKB (PubMed:16490392). [Isoform 1]: Monomer; acetylation by KAT5 promotes dissociation of the homodimer and monomerization. Cytoplasm, cytosol [Isoform 1]: Lipid droplet Note=Isoform 1 localizes to lipid droplets following phosphorylation by AMPK. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CHETK-alpha2 , CHKalpha2 ; IsoId=O54804-1; Sequence=Displayed; Name=2; Synonyms=CHETK-alpha1 , CHKalpha1 ; IsoId=O54804-2; Sequence=VSP_009684; Expressed ubiquitously with the highest level in testis. [Isoform 1]: Phosphorylated at Ser-275 by AMPK in response to glucose deprivation, leading to localization to lipid droplets. [Isoform 1]: Acetylated by KAT5 at Lys-243 following phosphorylation by AMPK, leading to monomerization and conversion into a tyrosine-protein kinase. Death at an early embryonic stage. Embryos die after 3 to 5 days of development. Belongs to the choline/ethanolamine kinase family. Sequence=AAH56758.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAA88154.1; Type=Erroneous gene model prediction; Evidence=; Sequence=BAB29191.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAC34841.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAC35539.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; nucleotide binding choline kinase activity cholinesterase activity ethanolamine kinase activity ATP binding cytoplasm ethanolamine metabolic process lipid metabolic process phosphatidylethanolamine biosynthetic process phosphatidylcholine biosynthetic process CDP-choline pathway drug binding phospholipid biosynthetic process response to toxic substance kinase activity phosphorylation transferase activity choline metabolic process choline binding protein homodimerization activity response to 3-methylcholanthrene uc008fxg.1 uc008fxg.2 uc008fxg.3 uc008fxg.4 
ENSMUST00000072079.9 Rrs1 ENSMUST00000072079.9 ribosome biogenesis regulator 1 (from RefSeq NM_021511.2) ENSMUST00000072079.1 ENSMUST00000072079.2 ENSMUST00000072079.3 ENSMUST00000072079.4 ENSMUST00000072079.5 ENSMUST00000072079.6 ENSMUST00000072079.7 ENSMUST00000072079.8 MNCb-2643 NM_021511 Q3UQW6 Q9CS27 Q9CYH6 Q9D2B2 Q9D6M6 Q9JJC1 RRS1_MOUSE Rrr uc007agk.1 uc007agk.2 uc007agk.3 Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. Nucleus, nucleolus Citrullinated by PADI4. Belongs to the RRS1 family. ribosomal large subunit assembly ribosomal large subunit export from nucleus endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) condensed nuclear chromosome fibrillar center hematopoietic progenitor cell differentiation protein binding nucleus nucleolus endoplasmic reticulum mitotic metaphase plate congression 5S rRNA binding preribosome, large subunit precursor ribosome biogenesis ribosomal large subunit biogenesis regulation of signal transduction by p53 class mediator protein localization to nucleolus uc007agk.1 uc007agk.2 uc007agk.3 
ENSMUST00000072080.10 Lrrc40 ENSMUST00000072080.10 leucine rich repeat containing 40, transcript variant 1 (from RefSeq NM_024194.7) A0A0R4J0W6 A0A0R4J0W6_MOUSE ENSMUST00000072080.1 ENSMUST00000072080.2 ENSMUST00000072080.3 ENSMUST00000072080.4 ENSMUST00000072080.5 ENSMUST00000072080.6 ENSMUST00000072080.7 ENSMUST00000072080.8 ENSMUST00000072080.9 Lrrc40 NM_024194 uc008rvu.1 uc008rvu.2 uc008rvu.3 uc008rvu.4 uc008rvu.1 uc008rvu.2 uc008rvu.3 uc008rvu.4 
ENSMUST00000072093.13 Plxnb1 ENSMUST00000072093.13 plexin B1 (from RefSeq NM_172775.2) E9QKS4 ENSMUST00000072093.1 ENSMUST00000072093.10 ENSMUST00000072093.11 ENSMUST00000072093.12 ENSMUST00000072093.2 ENSMUST00000072093.3 ENSMUST00000072093.4 ENSMUST00000072093.5 ENSMUST00000072093.6 ENSMUST00000072093.7 ENSMUST00000072093.8 ENSMUST00000072093.9 Kiaa0407 NM_172775 PLXB1_MOUSE Q6ZQC3 Q80ZZ1 Q8CJH3 uc009rrz.1 uc009rrz.2 uc009rrz.3 uc009rrz.4 Receptor for SEMA4D (PubMed:19788569). Plays a role in GABAergic synapse development (PubMed:23699507, PubMed:29981480). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (PubMed:23699507, PubMed:29981480). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (By similarity). Plays a role in axon guidance, invasive growth and cell migration (By similarity). Monomer, and heterodimer with PLXNB2 after proteolytic processing (By similarity). Binds RAC1 that has been activated by GTP binding (By similarity). Interaction with SEMA4D promotes binding of cytoplasmic ligands (By similarity). Interacts with RRAS, ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, RHOD, NRP1 and NRP2 (By similarity). Interacts with PLXNA1 (PubMed:12559962). Q8CJH3; Q68FM7: Arhgef11; NbExp=5; IntAct=EBI-2637650, EBI-2365869; Q8CJH3; Q8R4H2: Arhgef12; NbExp=2; IntAct=EBI-2637650, EBI-8046267; Cell membrane ; Single-pass type I membrane protein Detected in brain, heart, lung, liver, kidney, stomach, testis, uterus and placenta (PubMed:12559962). Expressed in neurons and glia in the developing hippocampus (PubMed:29981480). Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding. Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding. Belongs to the plexin family. semaphorin receptor complex protein binding plasma membrane integral component of plasma membrane negative regulation of cell adhesion signal transduction regulation of cell shape positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane semaphorin receptor activity regulation of cell migration GTPase activating protein binding negative regulation of osteoblast proliferation regulation of GTPase activity positive regulation of GTPase activity ossification involved in bone maturation neuron projection morphogenesis positive regulation of axonogenesis regulation of cytoskeleton organization semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis semaphorin-plexin signaling pathway involved in axon guidance inhibitory synapse assembly uc009rrz.1 uc009rrz.2 uc009rrz.3 uc009rrz.4 
ENSMUST00000072097.14 Hsh2d ENSMUST00000072097.14 hematopoietic SH2 domain containing (from RefSeq NM_197944.1) Alx ENSMUST00000072097.1 ENSMUST00000072097.10 ENSMUST00000072097.11 ENSMUST00000072097.12 ENSMUST00000072097.13 ENSMUST00000072097.2 ENSMUST00000072097.3 ENSMUST00000072097.4 ENSMUST00000072097.5 ENSMUST00000072097.6 ENSMUST00000072097.7 ENSMUST00000072097.8 ENSMUST00000072097.9 HSH2D_MOUSE NM_197944 Q52KL3 Q6VYH9 uc009mfl.1 uc009mfl.2 uc009mfl.3 Adapter protein involved in tyrosine kinase and CD28 signaling (By similarity). May be a modulator of the apoptotic response through its ability to affect mitochondrial stability. Interacts with FES and TNK2. Cytoplasm Mitochondrion Predominantly expressed in spleen and thymus. Appears not to be expressed in heart, brain, liver, kidney, embryo, lung and ovary. May be phosphorylated by FES and ACK1. negative regulation of B cell apoptotic process SH3/SH2 adaptor activity cytoplasm mitochondrion cytosol signal transduction positive regulation of signal transduction T cell activation negative regulation of mitochondrial depolarization uc009mfl.1 uc009mfl.2 uc009mfl.3 
ENSMUST00000072103.7 Try10 ENSMUST00000072103.7 trypsin 10 (from RefSeq NM_001038996.2) ENSMUST00000072103.1 ENSMUST00000072103.2 ENSMUST00000072103.3 ENSMUST00000072103.4 ENSMUST00000072103.5 ENSMUST00000072103.6 NM_001038996 Q792Z1 Q792Z1_MOUSE Tcrb-V20 Try10 trypsinogen uc009bou.1 uc009bou.2 uc009bou.3 uc009bou.4 Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4; Evidence=; serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009bou.1 uc009bou.2 uc009bou.3 uc009bou.4 
ENSMUST00000072113.6 Tmem65 ENSMUST00000072113.6 transmembrane protein 65 (from RefSeq NM_175212.4) ENSMUST00000072113.1 ENSMUST00000072113.2 ENSMUST00000072113.3 ENSMUST00000072113.4 ENSMUST00000072113.5 NM_175212 Q4VAE3 Q810S8 TMM65_MOUSE uc007vto.1 uc007vto.2 uc007vto.3 May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (PubMed:26403541). Regulates mitochondrial respiration and mitochondrial DNA copy number maintenance (By similarity). Monomer. Homodimer. Interacts with GJA1. Interacts weakly with DSP. Cell membrane ; Multi-pass membrane protein Mitochondrion inner membrane ; Multi-pass membrane protein Note=Localizes at the intercalated disk in ventricular tissue and cardiomyocytes. Predominantly expressed in the ventricular tissue (at protein level). Low level expression seen in the heart between 8.5 dpc and 15.5 dpc. Expression levels increase progressively after birth, with the highest levels seen in adults. Sequence=AAH49380.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cardiac ventricle development protein binding mitochondrion mitochondrial inner membrane plasma membrane intercalated disc membrane integral component of membrane regulation of cardiac conduction uc007vto.1 uc007vto.2 uc007vto.3 
ENSMUST00000072114.4 Or1j10 ENSMUST00000072114.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGK6) ENSMUST00000072114.1 ENSMUST00000072114.2 ENSMUST00000072114.3 Olfr338 Or1j10 Q8VGK6 Q8VGK6_MOUSE uc289vow.1 uc289vow.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vow.1 uc289vow.2 
ENSMUST00000072119.15 Ccnb1 ENSMUST00000072119.15 cyclin B1 (from RefSeq NM_172301.3) Ccnb1 ENSMUST00000072119.1 ENSMUST00000072119.10 ENSMUST00000072119.11 ENSMUST00000072119.12 ENSMUST00000072119.13 ENSMUST00000072119.14 ENSMUST00000072119.2 ENSMUST00000072119.3 ENSMUST00000072119.4 ENSMUST00000072119.5 ENSMUST00000072119.6 ENSMUST00000072119.7 ENSMUST00000072119.8 ENSMUST00000072119.9 NM_172301 Q3TQW9 Q3TQW9_MOUSE uc007rro.1 uc007rro.2 uc007rro.3 Essential for the control of the cell cycle at the G2/M (mitosis) transition. Belongs to the cyclin family. Cyclin AB subfamily. mitotic cell cycle spindle pole condensed nuclear chromosome outer kinetochore oocyte maturation negative regulation of protein phosphorylation patched binding nucleus cytoplasm mitochondrial matrix centrosome cytosol mitotic spindle organization mitotic metaphase plate congression spermatogenesis response to mechanical stimulus response to toxic substance negative regulation of gene expression positive regulation of G2/M transition of mitotic cell cycle histone phosphorylation protein kinase binding positive regulation of mRNA 3'-end processing positive regulation of histone phosphorylation histone kinase activity tissue regeneration response to drug ubiquitin-like protein ligase binding positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of mitotic cell cycle response to DDT digestive tract development regulation of cell cycle positive regulation of attachment of spindle microtubules to kinetochore ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation regulation of chromosome condensation cyclin-dependent protein serine/threonine kinase activator activity macromolecular complex assembly cellular response to iron(III) ion cellular response to fatty acid cellular response to organic cyclic compound cellular response to hypoxia regulation of mitotic cell cycle spindle assembly checkpoint cyclin B1-CDK1 complex positive regulation of mitochondrial ATP synthesis coupled electron transport uc007rro.1 uc007rro.2 uc007rro.3 
ENSMUST00000072141.4 Pdcd11 ENSMUST00000072141.4 programmed cell death 11 (from RefSeq NM_011053.2) Alg4 ENSMUST00000072141.1 ENSMUST00000072141.2 ENSMUST00000072141.3 Kiaa0185 NM_011053 Q3TSU4 Q3UGG2 Q3URK0 Q6NS46 Q6PIA8 Q6ZQH2 Q7TPE2 Q9CTD8 Q9R1Z2 Q9WTU7 RRP5_MOUSE uc008hup.1 uc008hup.2 uc008hup.3 uc008hup.4 uc008hup.5 Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (By similarity). Interacts with NF-kappa-B p50/NFKB1 and NF-kappa-B p65/RELA. Nucleus, nucleolus Ubiquitous. Sequence=AAD20941.1; Type=Miscellaneous discrepancy; Note=The mRNA 5'- and 3'-ends do not match to the genomic DNA.; Evidence=; Sequence=BAB23064.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC97890.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleic acid binding nucleus nucleolus cytosol rRNA processing RNA processing mRNA processing transcription factor binding small-subunit processome uc008hup.1 uc008hup.2 uc008hup.3 uc008hup.4 uc008hup.5 
ENSMUST00000072154.9 Pigh ENSMUST00000072154.9 phosphatidylinositol glycan anchor biosynthesis, class H (from RefSeq NM_029988.2) ENSMUST00000072154.1 ENSMUST00000072154.2 ENSMUST00000072154.3 ENSMUST00000072154.4 ENSMUST00000072154.5 ENSMUST00000072154.6 ENSMUST00000072154.7 ENSMUST00000072154.8 NM_029988 PIGH_MOUSE Pigh Q5M9N4 uc007nzs.1 uc007nzs.2 uc007nzs.3 uc007nzs.4 uc007nzs.5 Part of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Component of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts with PIGQ. Cytoplasm Belongs to the PIGH family. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex molecular_function cytoplasm GPI anchor biosynthetic process transferase activity transferase activity, transferring glycosyl groups phosphatidylinositol N-acetylglucosaminyltransferase activity uc007nzs.1 uc007nzs.2 uc007nzs.3 uc007nzs.4 uc007nzs.5 
ENSMUST00000072155.5 Cfap119 ENSMUST00000072155.5 cilia and flagella associated protein 119, transcript variant 4 (from RefSeq NR_175799.1) CF119_MOUSE Ccdc189 Cfap119 ENSMUST00000072155.1 ENSMUST00000072155.2 ENSMUST00000072155.3 ENSMUST00000072155.4 Gm166 NR_175799 Q3UST8 Q6NZQ0 uc009jwd.1 uc009jwd.2 uc009jwd.3 Cell projection, cilium, flagellum Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasm Note=In elongated spermatids, enriched in the principal piece of flagella where it is peri-axonemal. Disappears from sperm heads upon acrosome reaction. molecular_function cellular_component biological_process uc009jwd.1 uc009jwd.2 uc009jwd.3 
ENSMUST00000072167.10 Rhox2e ENSMUST00000072167.10 reproductive homeobox 2E (from RefSeq NM_001085348.1) ENSMUST00000072167.1 ENSMUST00000072167.2 ENSMUST00000072167.3 ENSMUST00000072167.4 ENSMUST00000072167.5 ENSMUST00000072167.6 ENSMUST00000072167.7 ENSMUST00000072167.8 ENSMUST00000072167.9 NM_001085348 Q9D4Y3 Q9D4Y3_MOUSE Rhox2a Rhox2e uc009syy.1 uc009syy.2 uc009syy.3 Nucleus negative regulation of transcription from RNA polymerase II promoter molecular_function DNA binding cellular_component nucleus biological_process uc009syy.1 uc009syy.2 uc009syy.3 
ENSMUST00000072177.14 Nuak2 ENSMUST00000072177.14 NUAK family, SNF1-like kinase, 2, transcript variant 1 (from RefSeq NM_001195025.2) ENSMUST00000072177.1 ENSMUST00000072177.10 ENSMUST00000072177.11 ENSMUST00000072177.12 ENSMUST00000072177.13 ENSMUST00000072177.2 ENSMUST00000072177.3 ENSMUST00000072177.4 ENSMUST00000072177.5 ENSMUST00000072177.6 ENSMUST00000072177.7 ENSMUST00000072177.8 ENSMUST00000072177.9 NM_001195025 NUAK2_MOUSE Nuak2 Omphk2 Q80ZW3 Q8BZN4 Q8CIC0 Q9DBV0 uc007cop.1 uc007cop.2 uc007cop.3 uc007cop.4 Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation on Thr-220. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8BZN4-1; Sequence=Displayed; Name=2 ; IsoId=Q8BZN4-2; Sequence=VSP_052095; First expressed in the anterior neuroectoderm at 7.5 dpc. At 8.5 dpc, the expression is present in future forebrain and midbrain regions. At 9.5 dpc, the expression is intense in the forebrain and midbrain with a sharp caudal boundary at the isthmic region; a low level of the expression is found throughout the neuroectoderm. Not expressed in the ventral body wall. Phosphorylated at Thr-220 by STK11/LKB1 in complex with STE20- related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylation is also possible at Thr-220. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation apoptotic process kinase activity phosphorylation nuclear speck transferase activity actin cytoskeleton organization intracellular signal transduction cellular response to glucose starvation negative regulation of apoptotic process metal ion binding uc007cop.1 uc007cop.2 uc007cop.3 uc007cop.4 
ENSMUST00000072180.5 Gm10062 ENSMUST00000072180.5 Gm10062 (from geneSymbol) ENSMUST00000072180.1 ENSMUST00000072180.2 ENSMUST00000072180.3 ENSMUST00000072180.4 uc290tum.1 uc290tum.2 uc290tum.1 uc290tum.2 
ENSMUST00000072182.9 Sim2 ENSMUST00000072182.9 single-minded family bHLH transcription factor 2 (from RefSeq NM_011377.2) ENSMUST00000072182.1 ENSMUST00000072182.2 ENSMUST00000072182.3 ENSMUST00000072182.4 ENSMUST00000072182.5 ENSMUST00000072182.6 ENSMUST00000072182.7 ENSMUST00000072182.8 NM_011377 O35391 Q61046 Q61079 Q61904 SIM2_MOUSE uc008aae.1 uc008aae.2 uc008aae.3 Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM2 and ARNT. Nucleus Transcripts were detected in high levels in kidney followed by skeletal muscle and lung. Low levels were found in testis, brain and heart. In early fetal development it is found in CNS, developing kidney, tongue epithelium and cartilage primordia. Sequence=AAA91202.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development nervous system development embryonic pattern specification nuclear body cell differentiation lung development negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity uc008aae.1 uc008aae.2 uc008aae.3 
ENSMUST00000072186.12 Strbp ENSMUST00000072186.12 Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Binds also to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA. (from UniProt Q91WM1) BC014710 ENSMUST00000072186.1 ENSMUST00000072186.10 ENSMUST00000072186.11 ENSMUST00000072186.2 ENSMUST00000072186.3 ENSMUST00000072186.4 ENSMUST00000072186.5 ENSMUST00000072186.6 ENSMUST00000072186.7 ENSMUST00000072186.8 ENSMUST00000072186.9 Q62262 Q91WM1 STRBP_MOUSE Spnr uc008jnd.1 uc008jnd.2 uc008jnd.3 uc008jnd.4 Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Binds also to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA. Interacts with EIF2AK2 (By similarity). Associates with microtubules; it is unsure whether such interaction is direct or indirect. [Isoform 2]: Cytoplasm, cytoskeleton. Note=Microtubule-associated that localizes to the manchette in developing spermatids. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91WM1-1; Sequence=Displayed; Name=2; IsoId=Q91WM1-2; Sequence=VSP_022938; Isoform 2 is expressed in spermatocytes (at protein level). Expressed in testis, thymus, ovary, liver, kidney, heart, spleen and brain. Expressed in cortex, dentate gyrus and Purkinje cell layer and granule cells of the cerebellum. Expressed in brain at 13.5 dpc. Expressed in brain, trigeminal ganglia and nasal epithelium at 18.5 dpc. manchette RNA binding double-stranded RNA binding single-stranded RNA binding nucleus cytoplasm cytoskeleton multicellular organism development spermatogenesis spermatid development mechanosensory behavior microtubule binding microtubule cytoskeleton tubulin binding cell differentiation DNA binding uc008jnd.1 uc008jnd.2 uc008jnd.3 uc008jnd.4 
ENSMUST00000072204.5 Klk1b8 ENSMUST00000072204.5 kallikrein 1-related peptidase b8 (from RefSeq NM_008457.3) ENSMUST00000072204.1 ENSMUST00000072204.2 ENSMUST00000072204.3 ENSMUST00000072204.4 K1KB8_MOUSE Klk-8 Klk8 NM_008457 P07628 uc009gob.1 uc009gob.2 uc009gob.3 uc009gob.4 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC031798.1, X03994.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Reaction=Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl- bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|- Xaa.; EC=3.4.21.35; Belongs to the peptidase S1 family. Kallikrein subfamily. regulation of systemic arterial blood pressure endopeptidase activity serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides secretory granule zymogen activation macromolecular complex uc009gob.1 uc009gob.2 uc009gob.3 uc009gob.4 
ENSMUST00000072206.14 Poc1a ENSMUST00000072206.14 POC1 centriolar protein A (from RefSeq NM_027354.2) ENSMUST00000072206.1 ENSMUST00000072206.10 ENSMUST00000072206.11 ENSMUST00000072206.12 ENSMUST00000072206.13 ENSMUST00000072206.2 ENSMUST00000072206.3 ENSMUST00000072206.4 ENSMUST00000072206.5 ENSMUST00000072206.6 ENSMUST00000072206.7 ENSMUST00000072206.8 ENSMUST00000072206.9 NM_027354 POC1A_MOUSE Q8JZX3 Q9CY09 Wdr51a uc009rjk.1 uc009rjk.2 uc009rjk.3 uc009rjk.4 Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation (By similarity). Interacts with POC1B. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, spindle pole Note=Component of both mother and daughter centrioles. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8JZX3-1; Sequence=Displayed; Name=2; IsoId=Q8JZX3-2; Sequence=VSP_017841; Name=3; IsoId=Q8JZX3-3; Sequence=VSP_017840, VSP_017841; Widely expressed in embryonic and adult tissues. Belongs to the WD repeat POC1 family. spindle pole growth plate cartilage chondrocyte development molecular_function cytoplasm centrosome centriole cytoskeleton mitotic spindle organization spermatogenesis positive regulation of centrosome duplication cell projection organization ciliary basal body cell projection bone development non-motile cilium assembly uc009rjk.1 uc009rjk.2 uc009rjk.3 uc009rjk.4 
ENSMUST00000072217.9 Ggt5 ENSMUST00000072217.9 gamma-glutamyltransferase 5, transcript variant 1 (from RefSeq NM_011820.5) ENSMUST00000072217.1 ENSMUST00000072217.2 ENSMUST00000072217.3 ENSMUST00000072217.4 ENSMUST00000072217.5 ENSMUST00000072217.6 ENSMUST00000072217.7 ENSMUST00000072217.8 GGT5_MOUSE Ggtla1 NM_011820 Q8C7B4 Q9Z2A9 uc007fqq.1 uc007fqq.2 uc007fqq.3 Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate (By similarity). Converts leukotriene C4 (LTC4), a glutathione-S-conjugate, to leukotriene D4 (LTD4) (PubMed:9774450, PubMed:11463821, PubMed:12163373). Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine. May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (By similarity). Reaction=an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]; Xref=Rhea:RHEA:23904, Rhea:RHEA-COMP:9780, Rhea:RHEA-COMP:9795, ChEBI:CHEBI:77644, ChEBI:CHEBI:78597, ChEBI:CHEBI:78599, ChEBI:CHEBI:78608; EC=2.3.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23905; Evidence=; Reaction=glutathione + H2O = L-cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:28807, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:57925, ChEBI:CHEBI:61694; EC=3.4.19.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28808; Evidence=; Reaction=an S-substituted glutathione + H2O = an S-substituted L- cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:59468, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:90779, ChEBI:CHEBI:143103; EC=3.4.19.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59469; Evidence=; Reaction=H2O + leukotriene C4 = L-glutamate + leukotriene D4; Xref=Rhea:RHEA:31563, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:57973, ChEBI:CHEBI:63166; EC=3.4.19.14; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31564; Evidence=; Reaction=H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione = L- glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine; Xref=Rhea:RHEA:65120, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:156326, ChEBI:CHEBI:156330; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65121; Evidence=; Inhibited by serine-borate. Lipid metabolism; leukotriene D4 biosynthesis. Sulfur metabolism; glutathione metabolism. Heterodimer composed of the light and heavy chains (PubMed:12163373). The active site is located in the light chain (By similarity). Membrane ; Single- pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z2A9-1; Sequence=Displayed; Name=2; IsoId=Q9Z2A9-2; Sequence=VSP_008147, VSP_008148; Very low level of expression. Detected in spleen lymphocytes, medullary and paracortical thymic lymphocytes, lung interstitial cells, bronchial epithelium, proximal tubules in kidney, crypt cells in small intestine, neurons in brain stem and cerebral cortex and in Purkinje cells. [Isoform 2]: Very low expression. Cleaved by autocatalysis into a large and a small subunit. Glycosylated. Deficient mice shown no obvious phenotype but in most organs they have only 10% of the wild-type levels of gamma- glutamyl leukotrienase activity (PubMed:11463821). Mice deficient in GGT5 have significantly more airway hyper-reactivity in a model of experimental asthma (PubMed:12163373). A previous study reported that GSH and oxidized glutathione (GSSG) are not substrates for murine GGT5 (PubMed:9774450). However, this result contrasts with two studies reported that GSH is indeed a substrate for GGT5 (By similarity). Belongs to the gamma-glutamyltransferase family. peptidyltransferase activity plasma membrane translation proteolysis cellular amino acid metabolic process fatty acid metabolic process glutathione metabolic process glutathione biosynthetic process glutathione catabolic process inflammatory response spermatogenesis peptidase activity membrane integral component of membrane transferase activity transferase activity, transferring acyl groups hydrolase activity leukotriene biosynthetic process intrinsic component of plasma membrane response to estradiol response to lipopolysaccharide response to tumor necrosis factor glutathione hydrolase activity leukotriene D4 biosynthetic process uc007fqq.1 uc007fqq.2 uc007fqq.3 
ENSMUST00000072222.8 Zfp329 ENSMUST00000072222.8 zinc finger protein 329 (from RefSeq NM_026046.3) ENSMUST00000072222.1 ENSMUST00000072222.2 ENSMUST00000072222.3 ENSMUST00000072222.4 ENSMUST00000072222.5 ENSMUST00000072222.6 ENSMUST00000072222.7 NM_026046 Q6GQR8 Q8BKL5 Q9D459 ZN329_MOUSE Znf329 uc009feh.1 uc009feh.2 uc009feh.3 uc009feh.4 uc009feh.5 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAB30425.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc009feh.1 uc009feh.2 uc009feh.3 uc009feh.4 uc009feh.5 
ENSMUST00000072232.9 Tmod3 ENSMUST00000072232.9 tropomodulin 3, transcript variant 1 (from RefSeq NM_016963.2) ENSMUST00000072232.1 ENSMUST00000072232.2 ENSMUST00000072232.3 ENSMUST00000072232.4 ENSMUST00000072232.5 ENSMUST00000072232.6 ENSMUST00000072232.7 ENSMUST00000072232.8 NM_016963 Q3TIT1 Q9JHJ0 TMOD3_MOUSE uc009qsi.1 uc009qsi.2 uc009qsi.3 Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). Binds to the N-terminus of tropomyosin and to actin. Cytoplasm, cytoskeleton Ubiquitous. Belongs to the tropomodulin family. ruffle actin binding tropomyosin binding cytoplasm cytoskeleton striated muscle thin filament muscle contraction myofibril lamellipodium actin cytoskeleton organization myofibril assembly filamentous actin erythrocyte development microtubule minus-end binding negative regulation of cellular component movement pointed-end actin filament capping positive regulation of mitotic cell cycle phase transition uc009qsi.1 uc009qsi.2 uc009qsi.3 
ENSMUST00000072235.10 1700019A02Rik ENSMUST00000072235.10 RIKEN cDNA 1700019A02 gene, transcript variant 1 (from RefSeq NM_027070.2) 1700019A02Rik ENSMUST00000072235.1 ENSMUST00000072235.2 ENSMUST00000072235.3 ENSMUST00000072235.4 ENSMUST00000072235.5 ENSMUST00000072235.6 ENSMUST00000072235.7 ENSMUST00000072235.8 ENSMUST00000072235.9 NM_027070 Q9DA74 Q9DA74_MOUSE uc007ayu.1 uc007ayu.2 uc007ayu.3 molecular_function cellular_component biological_process uc007ayu.1 uc007ayu.2 uc007ayu.3 
ENSMUST00000072237.13 Mink1 ENSMUST00000072237.13 misshapen-like kinase 1 (zebrafish), transcript variant 6 (from RefSeq NM_001403556.1) ENSMUST00000072237.1 ENSMUST00000072237.10 ENSMUST00000072237.11 ENSMUST00000072237.12 ENSMUST00000072237.2 ENSMUST00000072237.3 ENSMUST00000072237.4 ENSMUST00000072237.5 ENSMUST00000072237.6 ENSMUST00000072237.7 ENSMUST00000072237.8 ENSMUST00000072237.9 G3X9G2 G3X9G2_MOUSE Mink1 NM_001403556 uc007jvi.1 uc007jvi.2 regulation of cell-matrix adhesion protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm Golgi apparatus protein phosphorylation kinase activity phosphorylation regulation of cell-cell adhesion regulation of cell migration actin cytoskeleton reorganization positive regulation of JNK cascade protein autophosphorylation uc007jvi.1 uc007jvi.2 
ENSMUST00000072271.13 Etnppl ENSMUST00000072271.13 ethanolamine phosphate phospholyase, transcript variant 1 (from RefSeq NM_027907.3) AT2L1_MOUSE Agxt2l1 ENSMUST00000072271.1 ENSMUST00000072271.10 ENSMUST00000072271.11 ENSMUST00000072271.12 ENSMUST00000072271.2 ENSMUST00000072271.3 ENSMUST00000072271.4 ENSMUST00000072271.5 ENSMUST00000072271.6 ENSMUST00000072271.7 ENSMUST00000072271.8 ENSMUST00000072271.9 NM_027907 Q811K4 Q8BWU8 Q9DBB3 uc008rjb.1 uc008rjb.2 uc008rjb.3 uc008rjb.4 Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde. Reaction=H2O + phosphoethanolamine = acetaldehyde + NH4(+) + phosphate; Xref=Rhea:RHEA:17889, ChEBI:CHEBI:15343, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:43474, ChEBI:CHEBI:58190; EC=4.2.3.2; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Homotetramer. Mitochondrion Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Does not seem to possess aminotransferase activity. catalytic activity mitochondrion biological_process transaminase activity lyase activity pyridoxal phosphate binding ethanolamine-phosphate phospho-lyase activity uc008rjb.1 uc008rjb.2 uc008rjb.3 uc008rjb.4 
ENSMUST00000072280.5 Krtap8-1 ENSMUST00000072280.5 keratin associated protein 8-1 (from RefSeq NM_010675.1) ENSMUST00000072280.1 ENSMUST00000072280.2 ENSMUST00000072280.3 ENSMUST00000072280.4 KRA81_MOUSE NM_010675 O08633 Q3UZQ1 uc007zvr.1 uc007zvr.2 uc007zvr.3 uc007zvr.4 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Expression restricted exclusively to the cortical cells of hair follicles. Belongs to the KRTAP type 8 family. molecular_function cellular_component intermediate filament biological_process uc007zvr.1 uc007zvr.2 uc007zvr.3 uc007zvr.4 
ENSMUST00000072286.7 Gm5862 ENSMUST00000072286.7 predicted gene 5862 (from RefSeq NM_001281525.1) ENSMUST00000072286.1 ENSMUST00000072286.2 ENSMUST00000072286.3 ENSMUST00000072286.4 ENSMUST00000072286.5 ENSMUST00000072286.6 Gm5862 K7N5V5 K7N5V5_MOUSE NM_001281525 uc033iib.1 uc033iib.2 uc033iib.3 molecular_function cellular_component biological_process uc033iib.1 uc033iib.2 uc033iib.3 
ENSMUST00000072287.12 Pi4kb ENSMUST00000072287.12 phosphatidylinositol 4-kinase beta, transcript variant 2 (from RefSeq NM_175356.3) ENSMUST00000072287.1 ENSMUST00000072287.10 ENSMUST00000072287.11 ENSMUST00000072287.2 ENSMUST00000072287.3 ENSMUST00000072287.4 ENSMUST00000072287.5 ENSMUST00000072287.6 ENSMUST00000072287.7 ENSMUST00000072287.8 ENSMUST00000072287.9 NM_175356 PI4KB_MOUSE Pik4cb Q14CH6 Q14DJ4 Q3TA58 Q68FH2 Q8BKC8 Q8C146 uc008qhl.1 uc008qhl.2 uc008qhl.3 uc008qhl.4 uc008qhl.5 Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). May play an important role in the inner ear development. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216; EC=2.7.1.67; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19878; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ. Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (By similarity). Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity). Interacts with ACBD3. Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (By similarity). Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane (By similarity). Interacts with ATG9A. Endomembrane system Mitochondrion outer membrane ; Peripheral membrane protein Rough endoplasmic reticulum membrane ; Peripheral membrane protein Golgi apparatus Golgi apparatus membrane Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3, GGA2 is also involved in the recruitment (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BKC8-1; Sequence=Displayed; Name=2; IsoId=Q8BKC8-2; Sequence=VSP_037135; Name=3; IsoId=Q8BKC8-3; Sequence=VSP_037134; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. Golgi membrane nucleotide binding 1-phosphatidylinositol 4-kinase activity ATP binding cytoplasm mitochondrion mitochondrial outer membrane endoplasmic reticulum Golgi apparatus cytosol plasma membrane endomembrane system membrane kinase activity phosphorylation transferase activity rough endoplasmic reticulum membrane phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling 14-3-3 protein binding uc008qhl.1 uc008qhl.2 uc008qhl.3 uc008qhl.4 uc008qhl.5 
ENSMUST00000072289.12 Flot2 ENSMUST00000072289.12 flotillin 2, transcript variant 3 (from RefSeq NM_001284227.2) ENSMUST00000072289.1 ENSMUST00000072289.10 ENSMUST00000072289.11 ENSMUST00000072289.2 ENSMUST00000072289.3 ENSMUST00000072289.4 ENSMUST00000072289.5 ENSMUST00000072289.6 ENSMUST00000072289.7 ENSMUST00000072289.8 ENSMUST00000072289.9 Esa1 FLOT2_MOUSE M17s1 NM_001284227 Q5SS82 Q60634 Q6NS75 uc007khx.1 uc007khx.2 uc007khx.3 May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS (By similarity). Cell membrane ; Peripheral membrane protein Membrane, caveola ; Peripheral membrane protein Endosome Membrane ; Lipid-anchor Note=Membrane-associated protein of caveolae. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q60634-1; Sequence=Displayed; Name=2; IsoId=Q60634-2; Sequence=VSP_000502; Name=3; IsoId=Q60634-3; Sequence=VSP_037692; Expressed in many tissues, including suprabasal epidermis, hair follicles, heart, lung, thymus, spleen, liver, kidney and brain. Not expressed in skeletal muscle. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells. Belongs to the band 7/mec-2 family. Flotillin subfamily. membrane raft assembly uropod protease binding acrosomal membrane endosome plasma membrane caveola cell-cell adherens junction cell adhesion negative regulation of gene expression membrane basolateral plasma membrane flotillin complex lamellipodium endocytic vesicle cortical actin cytoskeleton cytoplasmic vesicle vesicle dendrite cytoplasm ionotropic glutamate receptor binding cell-cell contact zone protein localization to plasma membrane raft membrane raft synapse regulation of myoblast differentiation protein heterodimerization activity perinuclear region of cytoplasm protein stabilization positive regulation of NF-kappaB transcription factor activity protein localization to plasma membrane anterograde dendritic transport glutamatergic synapse anchored component of presynaptic active zone membrane regulation of postsynaptic specialization membrane neurotransmitter receptor levels negative regulation of amyloid precursor protein catabolic process positive regulation of establishment of T cell polarity uc007khx.1 uc007khx.2 uc007khx.3 
ENSMUST00000072299.7 Vsnl1 ENSMUST00000072299.7 visinin-like 1, transcript variant 1 (from RefSeq NM_012038.5) ENSMUST00000072299.1 ENSMUST00000072299.2 ENSMUST00000072299.3 ENSMUST00000072299.4 ENSMUST00000072299.5 ENSMUST00000072299.6 NM_012038 Nvp-1 Q4W4C9 Q4W4C9_MOUSE Vsnl1 uc011ykf.1 uc011ykf.2 uc011ykf.3 Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. Belongs to the recoverin family. calcium ion binding uc011ykf.1 uc011ykf.2 uc011ykf.3 
ENSMUST00000072306.4 Krtap2-22 ENSMUST00000072306.4 predicted gene 11938 (from RefSeq NM_001127354.1) ENSMUST00000072306.1 ENSMUST00000072306.2 ENSMUST00000072306.3 Gm11937 Gm11938 Krtap2-4 NM_001127354 Q9D3H4 Q9D3H4_MOUSE uc011yep.1 uc011yep.2 molecular_function cellular_component biological_process keratin filament uc011yep.1 uc011yep.2 
ENSMUST00000072311.13 Yes1 ENSMUST00000072311.13 YES proto-oncogene 1, Src family tyrosine kinase, transcript variant 1 (from RefSeq NM_009535.3) ENSMUST00000072311.1 ENSMUST00000072311.10 ENSMUST00000072311.11 ENSMUST00000072311.12 ENSMUST00000072311.2 ENSMUST00000072311.3 ENSMUST00000072311.4 ENSMUST00000072311.5 ENSMUST00000072311.6 ENSMUST00000072311.7 ENSMUST00000072311.8 ENSMUST00000072311.9 NM_009535 Q3TJI7 Q3TJI7_MOUSE Yes1 uc008wzu.1 uc008wzu.2 uc008wzu.3 uc008wzu.4 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Belongs to the protein kinase superfamily. Tyr protein kinase family. nucleotide binding phosphotyrosine binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity epidermal growth factor receptor binding ATP binding Golgi apparatus cytosol plasma membrane protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation enzyme binding ion channel binding protein autophosphorylation glutamatergic synapse postsynaptic specialization, intracellular component uc008wzu.1 uc008wzu.2 uc008wzu.3 uc008wzu.4 
ENSMUST00000072312.12 Usp13 ENSMUST00000072312.12 ubiquitin specific peptidase 13 (isopeptidase T-3) (from RefSeq NM_001013024.2) D3YYG7 ENSMUST00000072312.1 ENSMUST00000072312.10 ENSMUST00000072312.11 ENSMUST00000072312.2 ENSMUST00000072312.3 ENSMUST00000072312.4 ENSMUST00000072312.5 ENSMUST00000072312.6 ENSMUST00000072312.7 ENSMUST00000072312.8 ENSMUST00000072312.9 NM_001013024 Q5BKP2 UBP13_MOUSE uc008owr.1 uc008owr.2 uc008owr.3 Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Alternatively, forms with NEDD4 a deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34- containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Regulates the cell cycle progression by stabilizing cell cycle proteins such as SKP2 and AURKB. In addition, plays an important role in maintaining genomic stability and in DNA replication checkpoint activation via regulation of RAP80 and TOPBP1. Deubiquitinates the multifunctional protein HMGB1 and subsequently drives its nucleocytoplasmic localization and its secretion. Positively regulates type I and type II interferon signalings by deubiquitinating STAT1 but negatively regulates antiviral response by deubiquitinating STING1. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative of MBCQ that binds to USP13 and inhibits deubiquitinase activity. Regulated by PIK3C3/VPS34- containing complexes. The weak deubiquitinase activity in vitro suggests the existence of some mechanism that activates the enzyme (By similarity). Interacts with UFD1. Interacts (via UBA domains) with SIAH2 (when ubiquitinated). Interacts with BAG6; the interaction is direct and may mediate UBL4A deubiquitination. Interacts (via UBA 2 domain) with AMFR; the interaction is direct. Interacts with UBL4A; may be indirect via BAG6. Interacts with NEDD4. Cytoplasm The UBP-type zinc finger has lost its ability to bind ubiquitin and USP13 is not activated by unanchored ubiquitin. The UBA domains mediate binding to ubiquitin. Deficient mice are more resistant than wild-type littermates to lethal HSV-1 infection. In addition, USP13 deficiency impairs autophagy in lungs of aged mice (PubMed:36150040). Belongs to the peptidase C19 family. cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity regulation of transcription, DNA-templated proteolysis ubiquitin-dependent protein catabolic process autophagy peptidase activity cysteine-type peptidase activity zinc ion binding cell proliferation regulation of autophagy protein deubiquitination hydrolase activity ubiquitin protein ligase binding protein K29-linked deubiquitination thiol-dependent ubiquitinyl hydrolase activity ubiquitin binding protein K6-linked deubiquitination ubiquitin-like protein ligase binding metal ion binding protein stabilization chaperone binding protein K63-linked deubiquitination proteasome binding protein K48-linked deubiquitination BAT3 complex binding positive regulation of ERAD pathway maintenance of unfolded protein involved in ERAD pathway Lys48-specific deubiquitinase activity uc008owr.1 uc008owr.2 uc008owr.3 
ENSMUST00000072329.15 Dtnbp1 ENSMUST00000072329.15 dystrobrevin binding protein 1 (from RefSeq NM_025772.4) Bloc1s8 DTBP1_MOUSE ENSMUST00000072329.1 ENSMUST00000072329.10 ENSMUST00000072329.11 ENSMUST00000072329.12 ENSMUST00000072329.13 ENSMUST00000072329.14 ENSMUST00000072329.2 ENSMUST00000072329.3 ENSMUST00000072329.4 ENSMUST00000072329.5 ENSMUST00000072329.6 ENSMUST00000072329.7 ENSMUST00000072329.8 ENSMUST00000072329.9 NM_025772 Q3TWK1 Q6WXQ1 Q80ZN4 Q91WZ8 Q9CY43 Sdy uc007qgx.1 uc007qgx.2 uc007qgx.3 uc007qgx.4 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3- kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. Interacts with AP3M1 and TRIM32. Interacts (isoform 1 and isoform 2 only) with the DNA-dependent protein kinase complex DNA-PK; the interaction phosphorylates DTNBP1 in vitro. Interacts directly in this complex with XRCC5 and XRCC6. Interacts with XPO1; the interaction exports DTNBP1 out of the nucleus (By similarity). Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. This BLOC-1 complex also associates with the BLOC-2 complex in endosomes. Binds to DTNA and DTNB but may not be a physiological binding partner (PubMed:16448387, PubMed:16980328). Interacts (via its coiled coil domain) with KXD1. Interacts with AP3B2, BLOC1S5, BLOC1S6, CMYA5, PI4K2, RNF151 and SNAPIN/BLOC1S8. Interacts with XPO1; the interaction exports DTNBP1 out of the nucleus. Q91WZ8; Q70KF4: Cmya5; NbExp=5; IntAct=EBI-643186, EBI-782290; Q91WZ8; Q9D2N4: Dtna; NbExp=3; IntAct=EBI-643186, EBI-296019; [Isoform 1]: Cytoplasm. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Melanosome membrane; Peripheral membrane protein; Cytoplasmic side. Postsynaptic density. Endoplasmic reticulum Nucleus. Note=Mainly cytoplasmic but shuttles between the cytoplasm and nucleus. Exported out of the nucleus via its NES in a XPO1-dependent manner. Nuclear localization is required for regulation of the expression of genes such as SYN1. Detected in neuron cell bodies, axons and dendrites. Mainly located to the postsynaptic density. Detected at tubulovesicular elements in the vicinity of the Golgi apparatus and of melanosomes. Occasionally detected at the membrane of pigmented melanosomes in cultured melanoma cells (By similarity). The BLOC-1 complex associates with the BLOC-2 complex in early endosome-associated tubules. Associated with the AP-3 complex at presynaptic terminals. [Isoform 3]: Cytoplasm. Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Melanosome membrane ; Peripheral membrane protein ; Cytoplasmic side Postsynaptic cell membrane. Endoplasmic reticulum Note=Exclusivley cytoplasmic. Predominantly found in the postsynaptic density (PSD). Little association with synaptic vesicles (By similarity). The BLOC-1 complex associates with the BLOC-2 complex in early endosome-associated tubules. Vesicle membranes and microtubules. Associated with the AP-3 complex at presynaptic terminals. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Dysbindin 1-A; IsoId=Q91WZ8-1; Sequence=Displayed; Name=2; IsoId=Q91WZ8-2; Sequence=VSP_009024; Name=3; Synonyms=Dysbindin 1-C; IsoId=Q91WZ8-3; Sequence=VSP_021939; Detected in brain, in hippocampus and dentate gyrus neurons. Detected at axon bundles and axon terminals, notably in the cerebellum and hippocampus. Detected in neuropil in hippocampus, lateral septum, basal ganglia and substantia nigra. Highly expressed in pyramidal cells of hippocampus CA2 and CA3. Detected at the heart and skeletal muscle sarcolemma (at protein level). Ubiquitously expressed. The highest expression is observed in testis, liver, kidney, brain, heart and lung. Expressed at lower levels in stomach and small intestine. Ubiquitinated by TRIM32. Ubiquitination leads to DTNBP1 degradation. Note=Defects in Dtnbp1 are the cause of the sandy (sdy) mutant phenotype, a model for human Hermansky-Pudlak syndrome (HPS). Sdy mice lack dysbindin expression; they have a characteristic sandy coat color and have much fewer melanosomes in the retinal pigment epithelium and choroid. They are fully viable, but present behavioral abnormalities. They have prolonged bleeding times due to platelet storage pool deficiency, and lysosomal storage defects. The number of electron- opaque platelet dense granules is severely reduced, and the platelet serotonin content is strongly reduced. Secretion of lysosomal enzymes from kidney and from thrombin-stimulated platelets is depressed 2- and 3-fold, and ceroid pigment is present in kidney. Sandy mice also display impaired long-term memory retention and working memory and schizophrenia-like behavioral abnormalities. Vesicle morphology and kinetics of transmitter release are affected in both neuroendocrine cells and hippocampal synapses, characterized by larger vesicle size, slower quantal release, fewer release events and reduced readily releasable pool (RRP). Expression levels of SYN1 are lower in both the cortex and the hippocampal formation (HF). Null mice exhibit cognitive abnormalities including schizophrenia-related behaviors such as impaired working memory under stressful conditions. There is higher acoustic startle reactivity to stimuli. Pyramidal neurons are hypoexcitable on dopamine- 2 receptor stimulation. There is reduced expression of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and CaMKKbeta in the medial prefrontal cortex mPFC. There is increased expression levels of cell surface dopamine receptor D2 in cortical neurons. Expression levels of SYN1 are lower in both cortex and in the hippocampal formation (HF). Belongs to the dysbindin family. Sequence=AAH48682.1; Type=Frameshift; Evidence=; Sequence=BAE35265.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; positive regulation of protein phosphorylation positive regulation of neurotransmitter secretion positive regulation of receptor internalization protein binding nucleus cytoplasm endosome endoplasmic reticulum endoplasmic reticulum membrane plasma membrane organelle organization muscle organ development blood coagulation anterograde axonal transport endosome membrane positive regulation of gene expression regulation of dopamine secretion postsynaptic density microtubule cytoskeleton membrane sarcoplasm cell junction axon growth cone midbody cytoplasmic vesicle membrane synaptic vesicle membrane BLOC-1 complex neuron projection development cytoplasmic vesicle actin cytoskeleton reorganization negative regulation of protein binding asymmetric synapse melanosome membrane sarcolemma neuron projection neuronal cell body dendritic spine regulation of JUN kinase activity synapse postsynaptic membrane anterograde synaptic vesicle transport neuron projection morphogenesis dendrite morphogenesis response to stimulus platelet dense granule organization regulation of dopamine receptor signaling pathway negative regulation of dendritic spine morphogenesis positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization negative regulation of protein serine/threonine kinase activity glutamatergic synapse negative regulation of neuron death axon cytoplasm regulation of synaptic vesicle exocytosis uc007qgx.1 uc007qgx.2 uc007qgx.3 uc007qgx.4 
ENSMUST00000072334.12 Dnajc5 ENSMUST00000072334.12 DnaJ heat shock protein family (Hsp40) member C5, transcript variant 3 (from RefSeq NM_016775.3) Cspalpha DNJC5_MOUSE Dnajc5 ENSMUST00000072334.1 ENSMUST00000072334.10 ENSMUST00000072334.11 ENSMUST00000072334.2 ENSMUST00000072334.3 ENSMUST00000072334.4 ENSMUST00000072334.5 ENSMUST00000072334.6 ENSMUST00000072334.7 ENSMUST00000072334.8 ENSMUST00000072334.9 NM_016775 P54101 P60904 uc008omp.1 uc008omp.2 uc008omp.3 uc008omp.4 Acts as a co-chaperone for the SNARE protein SNAP-25 (PubMed:22187053). Involved in the calcium-mediated control of a late stage of exocytosis (PubMed:20847230). Acts as a general chaperone in regulated exocytosis (By similarity). May have an important role in presynaptic function (By similarity). May be involved in calcium- dependent neurotransmitter release at nerve endings (By similarity). Homodimer (Probable). Interacts with the chaperone complex consisting of HSC70 and SGTA (PubMed:17034881, PubMed:20847230). Interacts with ZDHHC13 (via ANK repeats) (PubMed:25253725, PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:25253725, PubMed:26198635). Interacts with SYT1, SYT5 and SYT7, and with SYT9, forming a complex with SNAP25 (PubMed:20847230). The interaction with SYT9 is stimulated tenfold in presence of calcium (PubMed:20847230). Cytoplasm, cytosol Membrane ; Lipid-anchor Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane Melanosome Cell membrane Note=The association with membranes is regulated by palmitoylation (By similarity). Colocalizes with insulin granules, when overexpressed in an islet cell line (PubMed:17034881). Formation of the chaperone complex DNAJC5/HSC70 is not regulated by phosphorylation (PubMed:20847230). Ser-10 phosphorylation induces an order-to-disorder transition triggering the interaction with Lys-58 (By similarity). This conformational switch modulates DNAJC5's cellular functions by reducing binding to syntaxin and synaptogamin without altering HSC70 interactions (By similarity). Palmitoylated (PubMed:17034881). Could be palmitoylated by DHHC3, DHHC7, DHHC15 and DHHC17 (By similarity). Palmitoylation occurs probably in the cysteine-rich domain and regulates DNAJC5 membrane attachment (PubMed:17034881). Defective SNAP-25 function, which causes neurodegeneration by impairing SNARE-complex assembly (PubMed:22187053). protein binding plasma membrane synaptic vesicle membrane neuromuscular junction melanosome ATP-dependent protein binding negative regulation of neuron apoptotic process chaperone-mediated protein folding presynapse anchored component of synaptic vesicle membrane uc008omp.1 uc008omp.2 uc008omp.3 uc008omp.4 
ENSMUST00000072359.8 Tpm3-rs7 ENSMUST00000072359.8 Cytoplasm, cytoskeleton (from UniProt D3Z2H9) AK145238 D3Z2H9 D3Z2H9_MOUSE ENSMUST00000072359.1 ENSMUST00000072359.2 ENSMUST00000072359.3 ENSMUST00000072359.4 ENSMUST00000072359.5 ENSMUST00000072359.6 ENSMUST00000072359.7 Tpm3-rs7 uc288wkq.1 uc288wkq.2 Cytoplasm, cytoskeleton Belongs to the tropomyosin family. actin filament actin filament organization actin filament binding uc288wkq.1 uc288wkq.2 
ENSMUST00000072363.5 Kprp ENSMUST00000072363.5 keratinocyte expressed, proline-rich (from RefSeq NM_028629.1) B2RUR4 ENSMUST00000072363.1 ENSMUST00000072363.2 ENSMUST00000072363.3 ENSMUST00000072363.4 KPRP_MOUSE Kprp NM_028629 Q9D1P8 uc008qes.1 uc008qes.2 Cytoplasm Sequence=BAB22669.1; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm biological_process uc008qes.1 uc008qes.2 
ENSMUST00000072376.13 Rnf14 ENSMUST00000072376.13 ring finger protein 14, transcript variant 2 (from RefSeq NM_020012.2) ENSMUST00000072376.1 ENSMUST00000072376.10 ENSMUST00000072376.11 ENSMUST00000072376.12 ENSMUST00000072376.2 ENSMUST00000072376.3 ENSMUST00000072376.4 ENSMUST00000072376.5 ENSMUST00000072376.6 ENSMUST00000072376.7 ENSMUST00000072376.8 ENSMUST00000072376.9 NM_020012 Q7TPR0 Q9D0L2 Q9D6N2 Q9D6Z8 Q9JI89 Q9JI90 RNF14_MOUSE Rnf14 Triad2 uc008ese.1 uc008ese.2 uc008ese.3 uc008ese.4 uc008ese.5 E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates ubiquitination of EEF1A1/eEF1A, leading to its degradation (By similarity). In addition to EEF1A1/eEF1A, RNF14 catalyzes ubiquitination of other translation factors on stalled ribosomes: mediates ubiquitination and degradation of ETF1/eRF1 and ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (By similarity). Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (By similarity). May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (By similarity). May regulate the expression of both mitochondrial and immune related genes in skeletal muscle (PubMed:24472305). Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence=; Protein modification; protein ubiquitination. Interacts with GCN1; interaction takes place in response to ribosome collisions and is required for ubiquitination of EEF1A1/eEF1A. Interacts with the ubiquitin-conjugating enzymes UBE2E1 and UBE2E2. Interacts with AR/androgen receptor. Interacts with TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4; promoting Wnt signaling. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JI90-1; Sequence=Displayed; Name=2; IsoId=Q9JI90-2; Sequence=VSP_005751, VSP_005752; The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway. Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT- type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain. RING-type zinc finger-dependent and UBE2E2-dependent autoubiquitination. Belongs to the RBR family. RNF14 subfamily. ubiquitin ligase complex protein polyubiquitination ubiquitin-protein transferase activity nucleus cytoplasm cytosol regulation of transcription, DNA-templated ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity ubiquitin-like protein transferase activity ubiquitin conjugating enzyme binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of transcription, DNA-templated metal ion binding androgen receptor binding regulation of androgen receptor signaling pathway ubiquitin protein ligase activity uc008ese.1 uc008ese.2 uc008ese.3 uc008ese.4 uc008ese.5 
ENSMUST00000072381.14 Ceacam23 ENSMUST00000072381.14 CEA cell adhesion moleculen23 (from RefSeq NM_001378684.1) A0A3Q4EGJ1 A0A3Q4EGJ1_MOUSE Ceacam23 ENSMUST00000072381.1 ENSMUST00000072381.10 ENSMUST00000072381.11 ENSMUST00000072381.12 ENSMUST00000072381.13 ENSMUST00000072381.2 ENSMUST00000072381.3 ENSMUST00000072381.4 ENSMUST00000072381.5 ENSMUST00000072381.6 ENSMUST00000072381.7 ENSMUST00000072381.8 ENSMUST00000072381.9 Gm5155 NM_001378684 uc291mel.1 uc291mel.2 molecular_function cellular_component biological_process uc291mel.1 uc291mel.2 
ENSMUST00000072383.14 Washc1 ENSMUST00000072383.14 WASH complex subunit 1, transcript variant 1 (from RefSeq NM_026833.1) ENSMUST00000072383.1 ENSMUST00000072383.10 ENSMUST00000072383.11 ENSMUST00000072383.12 ENSMUST00000072383.13 ENSMUST00000072383.2 ENSMUST00000072383.3 ENSMUST00000072383.4 ENSMUST00000072383.5 ENSMUST00000072383.6 ENSMUST00000072383.7 ENSMUST00000072383.8 ENSMUST00000072383.9 NM_026833 Orf19 Q3U473 Q8VDD8 WASH1_MOUSE Wash Wash1 Washc1 uc008dgy.1 uc008dgy.2 uc008dgy.3 Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875). Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function (PubMed:23275443). In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (PubMed:24886983). Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation (PubMed:24998208). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (PubMed:19732055). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (PubMed:23974797). Component of the WASH core complex also described as WASH regulatory complex SHRC composed of WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. The WASH core complex associates with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex. Interacts (via WHD1 region) with WASHC2; the interaction is direct (By similarity). Interacts with BECN1; WASHC1 and AMBRA1 can competitively interact with BECN1 (PubMed:23974797). Interacts with BLOC1S2; may associate with the BLOC-1 complex. Interacts with tubulin gamma chain (TUBG1 or TUBG2) (PubMed:20308062). Interacts with TBC1D23 (PubMed:29084197). Early endosome membrane Recycling endosome membrane Cytoplasmic vesicle, autophagosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localization to the endosome membrane is mediated via its interaction with WASHC2 (By similarity). Localized to Salmonella typhimurium entry sites (PubMed:19732055). Ubiquitously expressed. The VCA (verprolin, cofilin, acidic) domain promotes actin polymerization by the Arp2/3 complex in vitro. Ubiquitinated at Lys-219 via 'Lys-63'-linked ubiquitin chains by the TRIM27:MAGEL2 E3 ubiquitin ligase complex, leading to promote endosomal F-actin assembly. Belongs to the WASH1 family. Sequence=BAE32561.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; oocyte maturation dendritic cell antigen processing and presentation actin binding cytoplasm endosome early endosome autophagosome centrosome centriole cytosol cytoskeleton exocytosis endosome organization negative regulation of autophagy membrane endosomal transport extracellular matrix disassembly positive regulation of cell migration regulation of actin filament polymerization positive regulation of pseudopodium assembly regulation of protein ubiquitination cytoplasmic vesicle ubiquitin protein ligase binding early endosome membrane Arp2/3 complex-mediated actin nucleation low-density lipoprotein particle clearance protein localization to cell surface polar body extrusion after meiotic divisions T cell proliferation retrograde transport, endosome to Golgi alpha-tubulin binding gamma-tubulin binding intracellular membrane-bounded organelle negative regulation of phosphatidylinositol 3-kinase activity low-density lipoprotein particle receptor binding regulation of immune response recycling endosome recycling endosome membrane WASH complex invadopodium spindle assembly involved in meiosis endosome to plasma membrane protein transport positive regulation of cholesterol import retrograde transport, endosome to plasma membrane positive regulation of protein localization to cell surface exocyst BLOC-1 complex uc008dgy.1 uc008dgy.2 uc008dgy.3 
ENSMUST00000072391.2 H2ac1 ENSMUST00000072391.2 H2A clustered histone 1 (from RefSeq NM_175658.3) ENSMUST00000072391.1 H2ac1 Hist1h2aa NM_175658 Q8CGP4 Q8CGP4_MOUSE uc007pvj.1 uc007pvj.2 uc007pvj.3 uc007pvj.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC107355.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Chromosome Nucleus Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007pvj.1 uc007pvj.2 uc007pvj.3 uc007pvj.4 
ENSMUST00000072403.7 Ugt3a1 ENSMUST00000072403.7 UDP glycosyltransferases 3 family, polypeptide A2, transcript variant 1 (from RefSeq NM_144845.4) A1A4B4 ENSMUST00000072403.1 ENSMUST00000072403.2 ENSMUST00000072403.3 ENSMUST00000072403.4 ENSMUST00000072403.5 ENSMUST00000072403.6 NM_144845 Q3UP49 Q8JZZ0 Q8VC11 UD3A2_MOUSE Ugt3a2 uc007vfm.1 uc007vfm.2 uc007vfm.3 UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Membrane ; Single-pass type I membrane protein Highly expressed in kidney, while it is expressed at low levels in liver. Not detected in other tissues examined. Belongs to the UDP-glycosyltransferase family. UDP-glycosyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups intracellular membrane-bounded organelle cellular response to genistein uc007vfm.1 uc007vfm.2 uc007vfm.3 
ENSMUST00000072404.3 Tas2r104 ENSMUST00000072404.3 taste receptor, type 2, member 104 (from RefSeq NM_207011.1) A7MAX0 ENSMUST00000072404.1 ENSMUST00000072404.2 NM_207011 Q7M723 T2r45 TR104_MOUSE Tas2r104 uc009eiy.1 uc009eiy.2 Putative taste receptor which may play a role in the perception of bitterness. Membrane ; Multi-pass membrane protein Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane response to stimulus sensory perception of taste uc009eiy.1 uc009eiy.2 
ENSMUST00000072406.5 Prepl ENSMUST00000072406.5 prolyl endopeptidase-like, transcript variant 2 (from RefSeq NM_145984.3) ENSMUST00000072406.1 ENSMUST00000072406.2 ENSMUST00000072406.3 ENSMUST00000072406.4 Kiaa0436 NM_145984 PPCEL_MOUSE Q3TR35 Q6ZQB4 Q8BUP5 Q8C167 Q99KJ9 uc008dtp.1 uc008dtp.2 uc008dtp.3 uc008dtp.4 Serine peptidase whose precise substrate specificity remains unclear (PubMed:21692504). Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (PubMed:23321636). May play a role in the regulation of synaptic vesicle exocytosis (By similarity). Inhibited by 1-isobutyl-3-oxo-3,5,6,7-tetrahydro- 2H-cyclopenta[c]pyridine-4-carbonitrile. Homodimer (By similarity). Interacts with the AP-1 complex (By similarity). Cytoplasm, cytosol lgi apparatus, trans-Golgi network Cytoplasm, cytoskeleton Golgi apparatus Nucleus Note=Co-localizes with AP-1 in the trans-Golgi network (PubMed:23321636). Co-localizes with MAP2 and ACTB on the cytoskeleton (PubMed:23485813). Co-localizes with STX6 and GOSR2 at the Golgi apparatus (PubMed:23485813). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8C167-1; Sequence=Displayed; Name=2; IsoId=Q8C167-2; Sequence=VSP_030405; Name=3; IsoId=Q8C167-3; Sequence=VSP_030404; Name=4; IsoId=Q8C167-4; Sequence=VSP_030406, VSP_030407; Highly expressed in the brain, specifically in neurons of the neocortex, substantia nigra, locus coeruleus, and cerebellum, and a slightly lesser extent in neurons in the hypothalamus and hippocampus (at protein level) (PubMed:23321636, PubMed:23485813). Also expressed in interneurons in the stratum lacunosum moleculare and stratum radiatum (PubMed:23485813). PREPL-null mice are significantly shorter and lighter than their wild-type littermates and suffer from neonatal hypotonia. Belongs to the peptidase S9A family. Sequence=BAC97952.1; Type=Erroneous initiation; Evidence=; serine-type endopeptidase activity protein binding cytoplasm Golgi apparatus cytosol cytoskeleton proteolysis peptidase activity serine-type peptidase activity hydrolase activity retrograde transport, endosome to Golgi Golgi to plasma membrane protein transport serine-type exopeptidase activity regulation of synaptic vesicle exocytosis trans-Golgi network uc008dtp.1 uc008dtp.2 uc008dtp.3 uc008dtp.4 
ENSMUST00000072419.3 Or7g34 ENSMUST00000072419.3 olfactory receptor family 7 subfamily G member 34 (from RefSeq NM_146522.1) ENSMUST00000072419.1 ENSMUST00000072419.2 NM_146522 Olfr854 Or7g34 Q8VFF1 Q8VFF1_MOUSE uc009ohn.1 uc009ohn.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ohn.1 uc009ohn.2 
ENSMUST00000072437.5 Gm10113 ENSMUST00000072437.5 Gm10113 (from geneSymbol) AK028988 ENSMUST00000072437.1 ENSMUST00000072437.2 ENSMUST00000072437.3 ENSMUST00000072437.4 uc288mnu.1 uc288mnu.2 uc288mnu.1 uc288mnu.2 
ENSMUST00000072438.13 Cyp2b10 ENSMUST00000072438.13 cytochrome P450, family 2, subfamily b, polypeptide 10 (from RefSeq NM_009999.4) Cyp2b10 Cyp2b20 ENSMUST00000072438.1 ENSMUST00000072438.10 ENSMUST00000072438.11 ENSMUST00000072438.12 ENSMUST00000072438.2 ENSMUST00000072438.3 ENSMUST00000072438.4 ENSMUST00000072438.5 ENSMUST00000072438.6 ENSMUST00000072438.7 ENSMUST00000072438.8 ENSMUST00000072438.9 NM_009999 Q9WUD0 Q9WUD0_MOUSE uc009fue.1 uc009fue.2 uc009fue.3 uc009fue.4 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding metal ion binding oxidation-reduction process uc009fue.1 uc009fue.2 uc009fue.3 uc009fue.4 
ENSMUST00000072451.11 Slc9a7 ENSMUST00000072451.11 solute carrier family 9 (sodium/hydrogen exchanger), member 7 (from RefSeq NM_177353.4) A2ACD5 A2ACD6 ENSMUST00000072451.1 ENSMUST00000072451.10 ENSMUST00000072451.2 ENSMUST00000072451.3 ENSMUST00000072451.4 ENSMUST00000072451.5 ENSMUST00000072451.6 ENSMUST00000072451.7 ENSMUST00000072451.8 ENSMUST00000072451.9 NM_177353 Nhe7 Q8BLV3 SL9A7_MOUSE uc009sst.1 uc009sst.2 uc009sst.3 Golgi Na(+), K(+)/(H+) antiporter. Mediates the electoneutral influx of Na(+) or K(+) in exchange for H(+). May contribute to the regulation of Golgi apparatus volume and pH. Reaction=H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out); Xref=Rhea:RHEA:29419, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29420; Evidence=; Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out); Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29468; Evidence=; Interacts with SCAMP1, SCAMP2 and SCAMP5; may participate in its shuttling from trans-Golgi network to recycling endosomes. Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BLV3-1; Sequence=Displayed; Name=2; IsoId=Q8BLV3-2; Sequence=VSP_009498, VSP_009499; N-glycosylated. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. endosome Golgi apparatus trans-Golgi network plasma membrane ion transport cation transport potassium ion transport sodium ion transport regulation of pH antiporter activity solute:proton antiporter activity sodium:proton antiporter activity potassium:proton antiporter activity membrane integral component of membrane intracellular membrane-bounded organelle regulation of intracellular pH recycling endosome recycling endosome membrane transmembrane transport potassium ion transmembrane transport anion transmembrane transport sodium ion import across plasma membrane hydrogen ion transmembrane transport regulation of Golgi lumen acidification uc009sst.1 uc009sst.2 uc009sst.3 
ENSMUST00000072453.8 Lhb ENSMUST00000072453.8 luteinizing hormone beta (from RefSeq NM_008497.2) ENSMUST00000072453.1 ENSMUST00000072453.2 ENSMUST00000072453.3 ENSMUST00000072453.4 ENSMUST00000072453.5 ENSMUST00000072453.6 ENSMUST00000072453.7 G3X9G6 G3X9G6_MOUSE Lhb NM_008497 uc009gvb.1 uc009gvb.2 uc009gvb.3 Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin. Secreted Belongs to the glycoprotein hormones subunit beta family. hormone activity extracellular region signal transduction uc009gvb.1 uc009gvb.2 uc009gvb.3 
ENSMUST00000072465.9 Zfp809 ENSMUST00000072465.9 zinc finger protein 809, transcript variant 1 (from RefSeq NM_172763.3) ENSMUST00000072465.1 ENSMUST00000072465.2 ENSMUST00000072465.3 ENSMUST00000072465.4 ENSMUST00000072465.5 ENSMUST00000072465.6 ENSMUST00000072465.7 ENSMUST00000072465.8 G3X9G7 NM_172763 Q4KL58 Q8BIJ2 ZN809_MOUSE Zfp809 uc009oog.1 uc009oog.2 uc009oog.3 uc009oog.4 Transcription factor specifically required to repress retrotransposons in embryonic stem cells. Recognizes and binds retroviral DNA sequences from a large subset of mammalian retroviruses and retroelements and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:19270682). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=G3X9G7-1; Sequence=Displayed; Name=2; IsoId=G3X9G7-2; Sequence=VSP_057362, VSP_057363; Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding protein binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding innate immune response negative regulation of single stranded viral RNA replication via double stranded DNA intermediate metal ion binding uc009oog.1 uc009oog.2 uc009oog.3 uc009oog.4 
ENSMUST00000072475.9 Vmn2r30 ENSMUST00000072475.9 vomeronasal 2, receptor 30, transcript variant 1 (from RefSeq NM_009490.4) ENSMUST00000072475.1 ENSMUST00000072475.2 ENSMUST00000072475.3 ENSMUST00000072475.4 ENSMUST00000072475.5 ENSMUST00000072475.6 ENSMUST00000072475.7 ENSMUST00000072475.8 K7N5W1 K7N5W1_MOUSE NM_009490 Vmn2r30 uc012exr.1 uc012exr.2 uc012exr.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012exr.1 uc012exr.2 uc012exr.3 
ENSMUST00000072476.13 Oas1h ENSMUST00000072476.13 2'-5' oligoadenylate synthetase 1H, transcript variant 1 (from RefSeq NM_145228.2) ENSMUST00000072476.1 ENSMUST00000072476.10 ENSMUST00000072476.11 ENSMUST00000072476.12 ENSMUST00000072476.2 ENSMUST00000072476.3 ENSMUST00000072476.4 ENSMUST00000072476.5 ENSMUST00000072476.6 ENSMUST00000072476.7 ENSMUST00000072476.8 ENSMUST00000072476.9 NM_145228 Oas1h Q8VI97 Q8VI97_MOUSE oasl6 uc008zih.1 uc008zih.2 uc008zih.3 uc008zih.4 Belongs to the 2-5A synthase family. RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm cytosol immune response transferase activity nucleotidyltransferase activity negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity 2'-5'-oligoadenylate synthetase activity uc008zih.1 uc008zih.2 uc008zih.3 uc008zih.4 
ENSMUST00000072480.9 Fcrl1 ENSMUST00000072480.9 Fc receptor-like 1, transcript variant 2 (from RefSeq NM_178165.4) A0A0R4J0W8 A0A0R4J0W8_MOUSE ENSMUST00000072480.1 ENSMUST00000072480.2 ENSMUST00000072480.3 ENSMUST00000072480.4 ENSMUST00000072480.5 ENSMUST00000072480.6 ENSMUST00000072480.7 ENSMUST00000072480.8 Fcrl1 NM_178165 uc008psb.1 uc008psb.2 uc008psb.3 uc008psb.4 membrane integral component of membrane uc008psb.1 uc008psb.2 uc008psb.3 uc008psb.4 
ENSMUST00000072514.3 Myod1 ENSMUST00000072514.3 myogenic differentiation 1 (from RefSeq NM_010866.2) ENSMUST00000072514.1 ENSMUST00000072514.2 MYOD1_MOUSE Myod NM_010866 P10085 Q8C6B1 uc012fkv.1 uc012fkv.2 uc012fkv.3 Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation (PubMed:16901893). Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (PubMed:21798092, PubMed:3175662). Interacts with SUV39H1 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with DDX5. Interacts with CHD2. Interacts with TSC22D3 isoform 1 and isoform 4. Interacts with SETD3 (PubMed:21832073). Interacts with P-TEFB complex; promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation (PubMed:12037670). Interacts with CSRP3 (By similarity). Interacts with NUPR1 (PubMed:19723804). P10085; Q8VIM5-1: Myocd; NbExp=2; IntAct=EBI-4405734, EBI-15626132; P10085; Q6P9Z1: Smarcd3; NbExp=6; IntAct=EBI-4405734, EBI-7525857; P10085; O54864: Suv39h1; NbExp=3; IntAct=EBI-4405734, EBI-302230; P10085; P50463: Csrp3; Xeno; NbExp=3; IntAct=EBI-4405734, EBI-12502290; P10085; P17844: DDX5; Xeno; NbExp=3; IntAct=EBI-4405734, EBI-351962; P10085; Q92993: KAT5; Xeno; NbExp=5; IntAct=EBI-4405734, EBI-399080; P10085; Q02078: MEF2A; Xeno; NbExp=2; IntAct=EBI-4405734, EBI-2656305; Nucleus Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function. Ubiquitinated on the N-terminus; which is required for proteasomal degradation. Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation (By similarity). Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity. regulation of alternative mRNA splicing, via spliceosome nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development muscle organ development myoblast fate determination skeletal muscle tissue development myoblast fusion transcription factor binding cellular response to starvation regulation of gene expression myotube differentiation myotube cell development myotube differentiation involved in skeletal muscle regeneration nuclear body enzyme binding myofibril cell differentiation chromatin DNA binding ubiquitin protein ligase binding nuclear hormone receptor binding skeletal muscle cell differentiation skeletal muscle tissue regeneration positive regulation of skeletal muscle tissue regeneration regulation of RNA splicing skeletal muscle fiber adaptation sequence-specific DNA binding histone H3 acetylation histone H4 acetylation myoblast differentiation positive regulation of myoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity skeletal muscle fiber development positive regulation of skeletal muscle fiber development striated muscle cell differentiation positive regulation of muscle cell differentiation cardiac muscle cell differentiation E-box binding cellular response to tumor necrosis factor cellular response to glucocorticoid stimulus cellular response to estradiol stimulus cellular response to oxygen levels positive regulation of myoblast fusion positive regulation of snRNA transcription from RNA polymerase II promoter promoter-specific chromatin binding negative regulation of myoblast proliferation uc012fkv.1 uc012fkv.2 uc012fkv.3 
ENSMUST00000072518.8 Tgif2lx2 ENSMUST00000072518.8 TGFB-induced factor homeobox 2-like, X-linked 2 (from RefSeq NM_001142750.1) ENSMUST00000072518.1 ENSMUST00000072518.2 ENSMUST00000072518.3 ENSMUST00000072518.4 ENSMUST00000072518.5 ENSMUST00000072518.6 ENSMUST00000072518.7 NM_001142750 Q8K5B9 Q8K5B9_MOUSE Tgif2lx1 Tgif2lx2 uc009ueb.1 uc009ueb.2 uc009ueb.3 uc009ueb.4 Nucleus Belongs to the TALE/TGIF homeobox family. molecular_function DNA binding cellular_component nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding uc009ueb.1 uc009ueb.2 uc009ueb.3 uc009ueb.4 
ENSMUST00000072519.7 Elmo1 ENSMUST00000072519.7 engulfment and cell motility 1, transcript variant 3 (from RefSeq NM_080288.2) ELMO1_MOUSE ENSMUST00000072519.1 ENSMUST00000072519.2 ENSMUST00000072519.3 ENSMUST00000072519.4 ENSMUST00000072519.5 ENSMUST00000072519.6 NM_080288 Q8BPU7 Q8BSY9 Q8K2C5 Q91ZU3 uc007ppn.1 uc007ppn.2 uc007ppn.3 uc007ppn.4 uc007ppn.5 uc007ppn.6 Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3- binding site. Probably forms a heterotrimeric complex with DOCK1 and RAC1 (By similarity). Interacts with PLEKHG6. Interacts with HCK (via SH3 domain) (By similarity). Interacts with ADGRB1 (PubMed:17960134). Interacts with ADGRB3 (By similarity). Interacts with DOCK5 (PubMed:27505886). Q8BPU7-1; Q8BUR4: Dock1; NbExp=13; IntAct=EBI-644162, EBI-646023; Cytoplasm Cell membrane Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BPU7-1; Sequence=Displayed; Name=2; IsoId=Q8BPU7-2; Sequence=VSP_007481; Name=3; IsoId=Q8BPU7-3; Sequence=VSP_007482, VSP_007483; Name=4; IsoId=Q8BPU7-4; Sequence=VSP_007481, VSP_007484, VSP_007485; Phosphorylated by HCK. guanyl-nucleotide exchange factor activity protein binding cytoplasm plasma membrane phagocytosis phagocytosis, engulfment apoptotic process membrane cell migration Rac protein signal transduction SH3 domain binding actin filament-based process actin cytoskeleton organization guanyl-nucleotide exchange factor complex cell motility uc007ppn.1 uc007ppn.2 uc007ppn.3 uc007ppn.4 uc007ppn.5 uc007ppn.6 
ENSMUST00000072539.12 Csn1s2b ENSMUST00000072539.12 casein alpha s2-like B, transcript variant 1 (from RefSeq NM_009973.3) CS2LB_MOUSE Csnd Csne ENSMUST00000072539.1 ENSMUST00000072539.10 ENSMUST00000072539.11 ENSMUST00000072539.2 ENSMUST00000072539.3 ENSMUST00000072539.4 ENSMUST00000072539.5 ENSMUST00000072539.6 ENSMUST00000072539.7 ENSMUST00000072539.8 ENSMUST00000072539.9 NM_009973 P02664 Q3TP28 Q3TP29 Q542L5 uc008xyz.1 uc008xyz.2 uc008xyz.3 uc008xyz.4 uc008xyz.5 This gene is a member of the alpha-s2-like casein gene family, and this gene product is a calcium-sensitive casein. Members of this gene family are organized as a gene cluster that is conserved in its order, but with greater conservation amongst orthologs than paralogs. The protein encoded by this gene interacts with other casein proteins to form a micelle structure, and is a major source of protein in milk. This structure is important for the transport of calcium, phosphate, and protein. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Aug 2014]. Important role in the capacity of milk to transport calcium phosphate. Secreted. Mammary gland specific. Secreted in milk. Belongs to the alpha-casein family. extracellular region extracellular space zymogen binding protein homodimerization activity uc008xyz.1 uc008xyz.2 uc008xyz.3 uc008xyz.4 uc008xyz.5 
ENSMUST00000072554.13 9430015G10Rik ENSMUST00000072554.13 RIKEN cDNA 9430015G10 gene, transcript variant 2 (from RefSeq NM_145557.3) 9430015G10Rik A2ASP7 A2ASP7_MOUSE ENSMUST00000072554.1 ENSMUST00000072554.10 ENSMUST00000072554.11 ENSMUST00000072554.12 ENSMUST00000072554.2 ENSMUST00000072554.3 ENSMUST00000072554.4 ENSMUST00000072554.5 ENSMUST00000072554.6 ENSMUST00000072554.7 ENSMUST00000072554.8 ENSMUST00000072554.9 NM_145557 uc008wgd.1 uc008wgd.2 uc008wgd.3 uc008wgd.4 molecular_function cellular_component biological_process membrane integral component of membrane uc008wgd.1 uc008wgd.2 uc008wgd.3 uc008wgd.4 
ENSMUST00000072572.13 Alg11 ENSMUST00000072572.13 ALG11 alpha-1,2-mannosyltransferase, transcript variant 3 (from RefSeq NR_040650.1) ALG11_MOUSE ENSMUST00000072572.1 ENSMUST00000072572.10 ENSMUST00000072572.11 ENSMUST00000072572.12 ENSMUST00000072572.2 ENSMUST00000072572.3 ENSMUST00000072572.4 ENSMUST00000072572.5 ENSMUST00000072572.6 ENSMUST00000072572.7 ENSMUST00000072572.8 ENSMUST00000072572.9 NR_040650 Q3TZM9 Q6P7W8 Q8BL38 uc009lcn.1 uc009lcn.2 uc009lcn.3 Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain (By similarity). Reaction=alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha- D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)- [alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D- GlcNAc-diphosphodolichol + 2 GDP + 2 H(+); Xref=Rhea:RHEA:29523, Rhea:RHEA-COMP:12626, Rhea:RHEA-COMP:12627, ChEBI:CHEBI:15378, ChEBI:CHEBI:57527, ChEBI:CHEBI:58189, ChEBI:CHEBI:132511, ChEBI:CHEBI:132515; EC=2.4.1.131; Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TZM9-1; Sequence=Displayed; Name=2; IsoId=Q3TZM9-2; Sequence=VSP_026940; Name=3; IsoId=Q3TZM9-3; Sequence=VSP_026941; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein N-linked glycosylation oligosaccharide-lipid intermediate biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups mannosylation uc009lcn.1 uc009lcn.2 uc009lcn.3 
ENSMUST00000072576.10 Srp19 ENSMUST00000072576.10 signal recognition particle 19 (from RefSeq NM_025527.3) ENSMUST00000072576.1 ENSMUST00000072576.2 ENSMUST00000072576.3 ENSMUST00000072576.4 ENSMUST00000072576.5 ENSMUST00000072576.6 ENSMUST00000072576.7 ENSMUST00000072576.8 ENSMUST00000072576.9 NM_025527 Q9D104 Q9D104_MOUSE Srp19 uc008ekg.1 uc008ekg.2 uc008ekg.3 Cytoplasm Belongs to the SRP19 family. nucleolus signal recognition particle, endoplasmic reticulum targeting SRP-dependent cotranslational protein targeting to membrane 7S RNA binding response to drug ribosome binding signal recognition particle uc008ekg.1 uc008ekg.2 uc008ekg.3 
ENSMUST00000072578.8 Ube2d2b ENSMUST00000072578.8 ubiquitin-conjugating enzyme E2D 2B (from RefSeq NM_001276397.1) ENSMUST00000072578.1 ENSMUST00000072578.2 ENSMUST00000072578.3 ENSMUST00000072578.4 ENSMUST00000072578.5 ENSMUST00000072578.6 ENSMUST00000072578.7 NM_001276397 Q6ZWY6 U2D2B_MOUSE uc008yng.1 uc008yng.2 uc008yng.3 uc008yng.4 Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIG-I in response to viral infection (By similarity). Plays a role in early maturation of the testis. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence= Protein modification; protein ubiquitination. Interacts with CNOT4 (via RING domain). Testis-specific. Mice show a delay in postnatal testis development but normal spermatogenesis and fertility. Belongs to the ubiquitin-conjugating enzyme family. ubiquitin ligase complex nucleotide binding ubiquitin-protein transferase activity ATP binding ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity ubiquitin protein ligase binding protein K29-linked ubiquitination protein K27-linked ubiquitination ubiquitin conjugating enzyme activity protein K63-linked ubiquitination protein K48-linked ubiquitination protein K11-linked ubiquitination cellular response to cadmium ion protein K6-linked ubiquitination cellular response to arsenite(3-) uc008yng.1 uc008yng.2 uc008yng.3 uc008yng.4 
ENSMUST00000072581.9 Gps2 ENSMUST00000072581.9 Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'- linked ubiquitination (PubMed:22424771, PubMed:24953653, PubMed:28039360, PubMed:28123943, PubMed:29499132). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:18218630, PubMed:24953653, PubMed:25519902, PubMed:27270589, PubMed:28039360). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (PubMed:22666460, PubMed:24953653). Promotes cholesterol efflux by acting as a transcription coactivator (By similarity). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (PubMed:28039360). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes (PubMed:29499132). Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132). Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG (PubMed:25519902). Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (PubMed:27270589). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (By similarity). In the cytosol, also plays a non- transcriptional role by regulating insulin signaling and pro- inflammatory pathways (PubMed:22424771, PubMed:28123943). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the pro-inflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13 activity (PubMed:22424771). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13- mediated ubiquitination of AKT (PubMed:28123943). Able to suppress G- protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity). (from UniProt Q921N8) AF153696 ENSMUST00000072581.1 ENSMUST00000072581.2 ENSMUST00000072581.3 ENSMUST00000072581.4 ENSMUST00000072581.5 ENSMUST00000072581.6 ENSMUST00000072581.7 ENSMUST00000072581.8 GPS2_MOUSE Gps2 Q921N8 uc287zlc.1 uc287zlc.2 Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'- linked ubiquitination (PubMed:22424771, PubMed:24953653, PubMed:28039360, PubMed:28123943, PubMed:29499132). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:18218630, PubMed:24953653, PubMed:25519902, PubMed:27270589, PubMed:28039360). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (PubMed:22666460, PubMed:24953653). Promotes cholesterol efflux by acting as a transcription coactivator (By similarity). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (PubMed:28039360). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes (PubMed:29499132). Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132). Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG (PubMed:25519902). Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (PubMed:27270589). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (By similarity). In the cytosol, also plays a non- transcriptional role by regulating insulin signaling and pro- inflammatory pathways (PubMed:22424771, PubMed:28123943). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the pro-inflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13 activity (PubMed:22424771). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13- mediated ubiquitination of AKT (PubMed:28123943). Able to suppress G- protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity). Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (PubMed:25519902). Interacts (when sumoylated at Lys-71) with TBL1X; leading to protect GPS2 from degradation by the proteasome (PubMed:26070566). Interacts with UBE2N; leading to inhibit UBE2N/Ubc13 activity (PubMed:22424771). Interacts with TRAF1 (PubMed:22424771). Interacts with TRAF2 (PubMed:22424771). Interacts with TRAF6 (PubMed:22424771). Interacts with PPARG (when in the liganded conformation) (PubMed:25519902). Interacts with (sumoylated) NR1H2; interaction with sumoylated NR1H2 and NR5A2 onto hepatic acute phase protein promoters prevents N-Cor corepressor complex dissociation (By similarity). Interacts with (sumoylated) NR5A2; interaction with sumoylated NR1H2 and NR5A2 onto hepatic acute phase protein promoters prevents N-Cor corepressor complex dissociation (By similarity). Interacts with NR1H3 (By similarity). Interacts with RFX4 (PubMed:18218630). Interacts with ANKRD26 (By similarity). Nucleus Mitochondrion Cytoplasm, cytosol Note=Sumoylation regulates the subcellular location (PubMed:29499132). Relocates from the mitochondria to the nucleus following desumoylation, leading to mediate mitochondrial stress response (PubMed:29499132). Sumoylation regulates its subcellular location (PubMed:26070566, PubMed:29499132). Sumoylation at Lys-45 and Lys-71 regulates the shuttling between the cytoplasm and the nucleus (By similarity). Sumoylation at Lys-71 is required for interaction with TBL1X (PubMed:26070566). Sumoylated at Lys-45 and Lys-71 in mitochondrion (PubMed:29499132). Desumoylation by SENP1 leads to relocation from the mitochondria to the nucleus (PubMed:29499132). Ubiquitinated at the C-terminus by SIAH2; leading to its degradation by the proteasome. Interaction with TBL1X and methylation at Arg-323 protect GPS2 against ubiquitination and degradation. Methylated at Arg-312 and Arg-323 by PRMT6. Methylation at Arg-323 protects from degradation by the proteasome. Embryonic lethality (PubMed:25519902). Embryonic fibroblast cells show reduced corepressor function of the N-CoR complex for PPARG, leading to constitutive activation of PPARG target genes and spontaneous adipogenesis of the cells (PubMed:25519902). Conditional knockout mice lacking Gps2 in B-cells show developmental defects at multiple stages of B-cell differentiation, caused by of aberrant activation of 'Lys-63'-linked ubiquitination events and altered gene expression programs downstream of the misregulated signaling pathways (PubMed:28039360). Conditional knockout mice lacking Gps2 in macrophages show inappropriate corepressor complex function, leading to enhancer activation, pro-inflammatory gene expression and hypersensitivity toward metabolic-stress signals (PubMed:27270589). Conditional knockout mice lacking Gps2 in adipose tissues show obesity associated with constitutive insulin signaling, increased lipid deposition in the white adipose tissue and improved systemic insulin sensitivity (PubMed:28123943). Conditional knockout mice lacking Gps2 in adipose tissues display reduced mitochondrial content in brown adipose tissue (PubMed:29499132). negative regulation of transcription from RNA polymerase II promoter transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm cytoplasm mitochondrion cytosol negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of cholesterol efflux transcriptional repressor complex regulation of lipid metabolic process B cell differentiation cyclin binding negative regulation of toll-like receptor signaling pathway positive regulation of peroxisome proliferator activated receptor signaling pathway regulation of fat cell differentiation negative regulation of fat cell differentiation positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of inflammatory response negative regulation of B cell receptor signaling pathway response to mitochondrial depolarisation negative regulation of protein K63-linked ubiquitination uc287zlc.1 uc287zlc.2 
ENSMUST00000072593.9 Ssxa1 ENSMUST00000072593.9 Belongs to the SSX family. (from UniProt A0A5H1ZRK6) A0A5H1ZRK6 A0A5H1ZRK6_MOUSE AY244804 ENSMUST00000072593.1 ENSMUST00000072593.2 ENSMUST00000072593.3 ENSMUST00000072593.4 ENSMUST00000072593.5 ENSMUST00000072593.6 ENSMUST00000072593.7 ENSMUST00000072593.8 Ssxa1 uc292nlx.1 uc292nlx.2 Belongs to the SSX family. uc292nlx.1 uc292nlx.2 
ENSMUST00000072596.12 Ntng1 ENSMUST00000072596.12 netrin G1, transcript variant a (from RefSeq NM_030699.2) ENSMUST00000072596.1 ENSMUST00000072596.10 ENSMUST00000072596.11 ENSMUST00000072596.2 ENSMUST00000072596.3 ENSMUST00000072596.4 ENSMUST00000072596.5 ENSMUST00000072596.6 ENSMUST00000072596.7 ENSMUST00000072596.8 ENSMUST00000072596.9 Kiaa0976 Lmnt1 NM_030699 NTNG1_MOUSE Q68FE5 Q69ZU3 Q8R4F3 Q8R4F4 Q8R4F5 Q8R4F6 Q8R4F7 Q8R4F8 Q8R4F9 Q8R4G0 Q9ESR3 Q9ESR4 Q9ESR5 Q9ESR6 Q9ESR7 Q9ESR8 uc290ivl.1 uc290ivl.2 Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. Cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side Event=Alternative splicing; Named isoforms=10; Name=1A ; Synonyms=G1a ; IsoId=Q8R4G0-1; Sequence=Displayed; Name=1B ; Synonyms=G1b ; IsoId=Q8R4G0-2; Sequence=VSP_050547, VSP_050548; Name=1C ; Synonyms=G1c ; IsoId=Q8R4G0-3; Sequence=VSP_050549, VSP_050550; Name=1D ; Synonyms=G1d ; IsoId=Q8R4G0-4; Sequence=VSP_050551; Name=1E ; Synonyms=G1e ; IsoId=Q8R4G0-5; Sequence=VSP_050552, VSP_050553; Name=1F ; Synonyms=G1f ; IsoId=Q8R4G0-6; Sequence=VSP_050554, VSP_050555; Name=1G ; IsoId=Q8R4G0-7; Sequence=VSP_050558, VSP_050559; Name=1H ; IsoId=Q8R4G0-8; Sequence=VSP_050560, VSP_050561; Name=1I ; IsoId=Q8R4G0-9; Sequence=VSP_050556, VSP_050557; Name=1J ; IsoId=Q8R4G0-10; Sequence=VSP_050546; Expression is restricted primarily to neurons of the CNS, particularly in the dorsal thalamus, olfactory bulb and inferior colliculus. Isoform 1A and isoform 1D are the major products in adult brain. Detected in the midbrain and the hindbrain regions as early as 12 dpc. In the deep nucleus of the cerebellum, as well as in the inferior colliculus and the thalamic regions, expression is detected at 14 dpc, persists to postnatal day 1 and is down-regulated by postnatal day 12. At 14 dpc, expression is segmented in dorsal thalamus and pretectum in the midbrain and is regulated in a layer- specific manner in the superior colliculus. In the olfactory bulb, expression is detected at 14 dpc, increases by postnatal day 1 and is maintained at a high level through postnatal day 21 and into adulthood. The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains (By similarity). N-glycosylated. Sequence=BAD32353.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function protein binding plasma membrane multicellular organism development nervous system development axonogenesis animal organ morphogenesis tissue development membrane cell differentiation anchored component of membrane anchored component of plasma membrane modulation of synaptic transmission cell adhesion molecule binding protein binding involved in cell-cell adhesion glutamatergic synapse anchored component of presynaptic active zone membrane synaptic membrane adhesion uc290ivl.1 uc290ivl.2 
ENSMUST00000072600.7 Gja5 ENSMUST00000072600.7 gap junction protein, alpha 5, transcript variant 2 (from RefSeq NM_008121.3) CXA5_MOUSE Cxn-40 ENSMUST00000072600.1 ENSMUST00000072600.2 ENSMUST00000072600.3 ENSMUST00000072600.4 ENSMUST00000072600.5 ENSMUST00000072600.6 NM_008121 Q01231 uc008qop.1 uc008qop.2 uc008qop.3 uc008qop.4 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Cell membrane ; Multi-pass membrane protein Cell junction, gap junction. Abundantly expressed in the lung, also expressed in the kidney and heart. Expressed in arteries of the heart at 16.5 dpc (PubMed:28179430). Expressed in embryonic brain, skin, liver and kidney (PubMed:1318884). Belongs to the connexin family. Alpha-type (group II) subfamily. skeletal system development angiogenesis blood vessel development renal system process involved in regulation of systemic arterial blood pressure regulation of systemic arterial blood pressure negative regulation of glomerular filtration outflow tract morphogenesis endothelium development cardiac conduction system development mitral valve development pulmonary valve formation ventricular septum development atrial septum development septum primum development atrial ventricular junction remodeling gap junction channel activity plasma membrane integral component of plasma membrane gap junction connexin complex potassium ion transport cell communication heart development cell communication by chemical coupling cell communication by electrical coupling positive regulation of cell communication by chemical coupling intercalated disc membrane integral component of membrane gap junction assembly cell junction embryonic limb morphogenesis embryonic heart tube development foramen ovale closure cell projection negative regulation of blood pressure positive regulation of vasoconstriction artery morphogenesis protein oligomerization gap junction hemi-channel activity transmembrane transport regulation of cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization ventricular septum morphogenesis atrial septum morphogenesis cardiac conduction connexin binding ventricular cardiac muscle cell action potential SA node cell action potential atrial cardiac muscle cell to AV node cell communication by electrical coupling AV node cell to bundle of His cell communication by electrical coupling bundle of His cell to Purkinje myocyte communication by electrical coupling cell communication by electrical coupling involved in cardiac conduction cell communication involved in cardiac conduction AV node cell to bundle of His cell communication gap junction channel activity involved in cardiac conduction electrical coupling gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling regulation of heart rate by cardiac conduction disordered domain specific binding regulation of blood vessel diameter regulation of AV node cell action potential regulation of bundle of His cell action potential regulation of Purkinje myocyte action potential regulation of atrial cardiac muscle cell action potential regulation of renin secretion into blood stream regulation of membrane depolarization during cardiac muscle cell action potential vasomotion uc008qop.1 uc008qop.2 uc008qop.3 uc008qop.4 
ENSMUST00000072602.14 Hvcn1 ENSMUST00000072602.14 hydrogen voltage-gated channel 1, transcript variant 1 (from RefSeq NM_001042489.2) Bts ENSMUST00000072602.1 ENSMUST00000072602.10 ENSMUST00000072602.11 ENSMUST00000072602.12 ENSMUST00000072602.13 ENSMUST00000072602.2 ENSMUST00000072602.3 ENSMUST00000072602.4 ENSMUST00000072602.5 ENSMUST00000072602.6 ENSMUST00000072602.7 ENSMUST00000072602.8 ENSMUST00000072602.9 HVCN1_MOUSE NM_001042489 Q3U2S8 Q9DCE4 Vsop uc008zku.1 uc008zku.2 uc008zku.3 Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. The dimers display cooperative channel gating. The channel activity is inhibited by zinc ions. Homodimer. Q3U2S8; Q3U2S8: Hvcn1; NbExp=3; IntAct=EBI-8401579, EBI-8401579; Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Enriched in immune tissues, such as bone marrow, macrophages and spleen. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain. The C-terminal coiled coil region mediates homodimerization and cooperative channel gating. It is essential for normal subcellular localization. Phosphorylation may enhance channel gating. Belongs to the hydrogen channel family. ion channel activity voltage-gated ion channel activity plasma membrane integral component of plasma membrane ion transport response to pH response to zinc ion membrane integral component of membrane voltage-gated cation channel activity voltage-gated proton channel activity regulation of ion transmembrane transport identical protein binding transmembrane transport cellular response to zinc ion cellular response to pH hydrogen ion transmembrane transport uc008zku.1 uc008zku.2 uc008zku.3 
ENSMUST00000072631.6 Nkx2-9 ENSMUST00000072631.6 NK2 homeobox 9 (from RefSeq NM_008701.2) B2RWY9 ENSMUST00000072631.1 ENSMUST00000072631.2 ENSMUST00000072631.3 ENSMUST00000072631.4 ENSMUST00000072631.5 NKX28_MOUSE NM_008701 Nkx-2.9 Nkx2-8 Nkx2h O70584 uc007nph.1 uc007nph.2 uc007nph.3 uc007nph.4 Possible role in the specification of a distinct subset of neurons. Nucleus Prominent expression in ventral brain and neural tube structures. Belongs to the NK-2 homeobox family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development axonogenesis cell differentiation respiratory tube development lung development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter negative regulation of epithelial cell proliferation uc007nph.1 uc007nph.2 uc007nph.3 uc007nph.4 
ENSMUST00000072634.15 Aplp2 ENSMUST00000072634.15 amyloid beta precursor-like protein 2, transcript variant 1 (from RefSeq NM_001102455.2) APLP2 Aplp2 ENSMUST00000072634.1 ENSMUST00000072634.10 ENSMUST00000072634.11 ENSMUST00000072634.12 ENSMUST00000072634.13 ENSMUST00000072634.14 ENSMUST00000072634.2 ENSMUST00000072634.3 ENSMUST00000072634.4 ENSMUST00000072634.5 ENSMUST00000072634.6 ENSMUST00000072634.7 ENSMUST00000072634.8 ENSMUST00000072634.9 NM_001102455 Q60709 Q60709_MOUSE uc009orm.1 uc009orm.2 uc009orm.3 Membrane ; Single- pass type I membrane protein Belongs to the APP family. Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase inhibitor activity nucleus heparin binding negative regulation of endopeptidase activity membrane integral component of membrane identical protein binding transition metal ion binding uc009orm.1 uc009orm.2 uc009orm.3 
ENSMUST00000072662.12 Zscan5b ENSMUST00000072662.12 zinc finger and SCAN domain containing 5B (from RefSeq NM_133204.2) B2RTN3 B2RTN3_MOUSE ENSMUST00000072662.1 ENSMUST00000072662.10 ENSMUST00000072662.11 ENSMUST00000072662.2 ENSMUST00000072662.3 ENSMUST00000072662.4 ENSMUST00000072662.5 ENSMUST00000072662.6 ENSMUST00000072662.7 ENSMUST00000072662.8 ENSMUST00000072662.9 NM_133204 Zscan5b uc009faz.1 uc009faz.2 uc009faz.3 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009faz.1 uc009faz.2 uc009faz.3 
ENSMUST00000072666.4 Zfp474 ENSMUST00000072666.4 zinc finger protein 474, transcript variant 2 (from RefSeq NM_025749.3) ENSMUST00000072666.1 ENSMUST00000072666.2 ENSMUST00000072666.3 NM_025749 Q6V5K9 Q9D472 Q9D985 ZN474_MOUSE Znf474 uc008exi.1 uc008exi.2 uc008exi.3 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; molecular_function cellular_component biological_process metal ion binding uc008exi.1 uc008exi.2 uc008exi.3 
ENSMUST00000072678.6 Mup13 ENSMUST00000072678.6 major urinary protein 13 (from RefSeq NM_001347134.1) A2CEK6 A2CEK6_MOUSE ENSMUST00000072678.1 ENSMUST00000072678.2 ENSMUST00000072678.3 ENSMUST00000072678.4 ENSMUST00000072678.5 Mup11 Mup13 Mup14 NM_001347134 OTTMUSG00000012492 OTTMUSG00000012493 uc290nbk.1 uc290nbk.2 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc290nbk.1 uc290nbk.2 
ENSMUST00000072695.13 Tle1 ENSMUST00000072695.13 transducin-like enhancer of split 1, transcript variant 1 (from RefSeq NM_011599.5) ENSMUST00000072695.1 ENSMUST00000072695.10 ENSMUST00000072695.11 ENSMUST00000072695.12 ENSMUST00000072695.2 ENSMUST00000072695.3 ENSMUST00000072695.4 ENSMUST00000072695.5 ENSMUST00000072695.6 ENSMUST00000072695.7 ENSMUST00000072695.8 ENSMUST00000072695.9 NM_011599 Q5SQA2 Q5SQA2_MOUSE Tle1 uc008tif.1 uc008tif.2 uc008tif.3 uc008tif.4 uc008tif.5 Nucleus Belongs to the WD repeat Groucho/TLE family. transcription corepressor activity nucleus nucleoplasm cytosol regulation of transcription, DNA-templated transcription factor binding positive regulation of gene expression identical protein binding negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of transcription, DNA-templated beta-catenin-TCF complex negative regulation of anoikis uc008tif.1 uc008tif.2 uc008tif.3 uc008tif.4 uc008tif.5 
ENSMUST00000072697.13 Acadm ENSMUST00000072697.13 acyl-Coenzyme A dehydrogenase, medium chain (from RefSeq NM_007382.5) ACADM_MOUSE Acadm ENSMUST00000072697.1 ENSMUST00000072697.10 ENSMUST00000072697.11 ENSMUST00000072697.12 ENSMUST00000072697.2 ENSMUST00000072697.3 ENSMUST00000072697.4 ENSMUST00000072697.5 ENSMUST00000072697.6 ENSMUST00000072697.7 ENSMUST00000072697.8 ENSMUST00000072697.9 NM_007382 P45952 Q64235 uc008ruj.1 uc008ruj.2 uc008ruj.3 uc008ruj.4 This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C6- and C12-acylCoA. In mice, deficiency of this gene can cause neonatal mortality as well as fasting and cold intolerance. This gene has multiple, intronless pseudogenes. [provided by RefSeq, Nov 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. The transit peptide annotated at aa 1-25 is inferred by similarity to the cleavage site in the orthologous rat protein as described in PMID: 2777793. The software program TargetP1.1 predicts that the transit peptide in mouse is aa 1-27. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146444.1, U07159.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849390, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:16121256). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl- CoA (PubMed:16121256). Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains (PubMed:16121256). Reaction=a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:14477, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:83723, ChEBI:CHEBI:83726; EC=1.3.8.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14478; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl- CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:43456, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57389, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:86160; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43457; Evidence=; Reaction=H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:43464, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:62077, ChEBI:CHEBI:62620; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43465; Evidence=; Reaction=H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:48180, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57386, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:62242; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48181; Evidence=; Reaction=decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:48176, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:61406, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48177; Evidence=; Reaction=dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47296, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57330, ChEBI:CHEBI:57375, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47297; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:47316, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57385, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:61405; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47317; Evidence=; Reaction=H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:43448, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57379, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:61526; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43449; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Lipid metabolism; mitochondrial fatty acid beta-oxidation. Homotetramer. Interacts with the heterodimeric electron transfer flavoprotein ETF. Mitochondrion matrix Acetylated. Could occur at proximity of the cofactor-binding sites and reduce the catalytic activity. Could be deacetylated by SIRT3. Mice lacking Mcad show increased neonatal mortality (PubMed:16121256). They display hypothermia and cold intolerance upon fasting (PubMed:16121256). Their serum and bile acylcarnitine profile is also different from wild-type mice, with an elevation of serum decenoylcarnitine compared to wild-type mice (PubMed:16121256). They also display hepatic steatosis following fast periods (PubMed:16121256). They develop significantly elevated concentrations of urinary adipic, suberic, and sebacic acids and hexanoylglycine (PubMed:16121256). Belongs to the acyl-CoA dehydrogenase family. fatty-acyl-CoA binding liver development acyl-CoA dehydrogenase activity mitochondrion mitochondrial matrix glycogen biosynthetic process organic acid metabolic process regulation of gluconeogenesis lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation heart development response to cold carnitine metabolic process post-embryonic development oxidoreductase activity nuclear speck oxidoreductase activity, acting on the CH-CH group of donors isomerase activity carnitine metabolic process, CoA-linked axon mitochondrial membrane fatty acid beta-oxidation using acyl-CoA dehydrogenase response to starvation identical protein binding carnitine biosynthetic process flavin adenine dinucleotide binding protein homotetramerization medium-chain fatty acid metabolic process medium-chain fatty acid catabolic process cardiac muscle cell differentiation oxidation-reduction process medium-chain-acyl-CoA dehydrogenase activity uc008ruj.1 uc008ruj.2 uc008ruj.3 uc008ruj.4 
ENSMUST00000072699.13 Hmgb3 ENSMUST00000072699.13 high mobility group box 3, transcript variant 10 (from RefSeq NM_001411302.1) ENSMUST00000072699.1 ENSMUST00000072699.10 ENSMUST00000072699.11 ENSMUST00000072699.12 ENSMUST00000072699.2 ENSMUST00000072699.3 ENSMUST00000072699.4 ENSMUST00000072699.5 ENSMUST00000072699.6 ENSMUST00000072699.7 ENSMUST00000072699.8 ENSMUST00000072699.9 Hmgb3 NM_001411302 Q544R9 Q544R9_MOUSE uc009tkb.1 uc009tkb.2 uc009tkb.3 uc009tkb.4 Chromosome Nucleus Belongs to the HMGB family. four-way junction DNA binding DNA binding nucleus DNA binding, bending DNA geometric change uc009tkb.1 uc009tkb.2 uc009tkb.3 uc009tkb.4 
ENSMUST00000072726.7 Wdr7 ENSMUST00000072726.7 WD repeat domain 7, transcript variant 1 (from RefSeq NM_001014981.1) ENSMUST00000072726.1 ENSMUST00000072726.2 ENSMUST00000072726.3 ENSMUST00000072726.4 ENSMUST00000072726.5 ENSMUST00000072726.6 Kiaa0541 NM_001014981 Q059Q1 Q3U440 Q80TY3 Q920I9 Q920J0 Trag WDR7_MOUSE uc008fea.1 uc008fea.2 uc008fea.3 uc008fea.4 uc008fea.5 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q920I9-1; Sequence=Displayed; Name=2; IsoId=Q920I9-2; Sequence=VSP_015275; hematopoietic progenitor cell differentiation molecular_function synaptic vesicle uc008fea.1 uc008fea.2 uc008fea.3 uc008fea.4 uc008fea.5 
ENSMUST00000072729.10 Ms4a4c ENSMUST00000072729.10 membrane-spanning 4-domains, subfamily A, member 4C (from RefSeq NM_029499.3) ENSMUST00000072729.1 ENSMUST00000072729.2 ENSMUST00000072729.3 ENSMUST00000072729.4 ENSMUST00000072729.5 ENSMUST00000072729.6 ENSMUST00000072729.7 ENSMUST00000072729.8 ENSMUST00000072729.9 Ms4a4c NM_029499 Q99N06 Q9D3F6 Q9D3F6_MOUSE uc008gsc.1 uc008gsc.2 uc008gsc.3 Belongs to the MS4A family. molecular_function cellular_component biological_process membrane integral component of membrane uc008gsc.1 uc008gsc.2 uc008gsc.3 
ENSMUST00000072735.9 Antkmt ENSMUST00000072735.9 adenine nucleotide translocase lysine methyltransferase, transcript variant 1 (from RefSeq NM_145410.4) ANKMT_MOUSE Antkmt ENSMUST00000072735.1 ENSMUST00000072735.2 ENSMUST00000072735.3 ENSMUST00000072735.4 ENSMUST00000072735.5 ENSMUST00000072735.6 ENSMUST00000072735.7 ENSMUST00000072735.8 Fam173a NM_145410 Q501J2 uc008bbx.1 uc008bbx.2 uc008bbx.3 uc008bbx.4 uc008bbx.5 Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration. Probably also trimethylates ANT1/SLC25A4. Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54193; Evidence=; Mitochondrion membrane ; Single-pass membrane protein The pre-methyltransferase (preMT) region is responsible for mitochondrial localization. Belongs to the ANT/ATPSC lysine N-methyltransferase family. molecular_function cellular_component biological_process methyltransferase activity membrane integral component of membrane protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine methylation methylation uc008bbx.1 uc008bbx.2 uc008bbx.3 uc008bbx.4 uc008bbx.5 
ENSMUST00000072744.15 Vipas39 ENSMUST00000072744.15 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog, transcript variant 1 (from RefSeq NM_001142580.1) ENSMUST00000072744.1 ENSMUST00000072744.10 ENSMUST00000072744.11 ENSMUST00000072744.12 ENSMUST00000072744.13 ENSMUST00000072744.14 ENSMUST00000072744.2 ENSMUST00000072744.3 ENSMUST00000072744.4 ENSMUST00000072744.5 ENSMUST00000072744.6 ENSMUST00000072744.7 ENSMUST00000072744.8 ENSMUST00000072744.9 NM_001142580 Q8BGQ1 Q8BL55 Q8CIK4 Q91YI3 SPE39_MOUSE Spe39 Vipar uc007oiq.1 uc007oiq.2 uc007oiq.3 uc007oiq.4 Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (By similarity). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E- cadherin. Interacts with VPS33B (By similarity). Associates with the homotypic fusion and vacuole protein sorting (HOPS) complex; impaired by VPS33B (By similarity). Interacts with RAB11A (PubMed:20190753). Cytoplasm Cytoplasmic vesicle Early endosome Recycling endosome Late endosome Note=Colocalizes in clusters with VPS33B at cytoplasmic organelles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGQ1-1; Sequence=Displayed; Name=2; IsoId=Q8BGQ1-2; Sequence=VSP_009285; Vipar-deficient inner medullary collecting duct cells display abnormal expression of membrane proteins such as Ceacam5, structural and functional tight junction defects and reduced E-cadherin expression. Belongs to the SPE39 family. cytoplasm endosome early endosome late endosome Golgi apparatus intracellular protein transport spermatogenesis endosome to lysosome transport protein transport peptidyl-lysine hydroxylation cell differentiation collagen fibril organization cytoplasmic vesicle collagen metabolic process post-translational protein modification macromolecular complex binding recycling endosome uc007oiq.1 uc007oiq.2 uc007oiq.3 uc007oiq.4 
ENSMUST00000072748.13 Ms4a10 ENSMUST00000072748.13 membrane-spanning 4-domains, subfamily A, member 10, transcript variant 1 (from RefSeq NM_023529.3) ENSMUST00000072748.1 ENSMUST00000072748.10 ENSMUST00000072748.11 ENSMUST00000072748.12 ENSMUST00000072748.2 ENSMUST00000072748.3 ENSMUST00000072748.4 ENSMUST00000072748.5 ENSMUST00000072748.6 ENSMUST00000072748.7 ENSMUST00000072748.8 ENSMUST00000072748.9 M4A10_MOUSE NM_023529 Q99N03 Q9D8H8 Q9EQY8 uc008grk.1 uc008grk.2 uc008grk.3 May be involved in signal transduction as a component of a multimeric receptor complex. Membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99N03-1; Sequence=Displayed; Name=2; IsoId=Q99N03-2; Sequence=VSP_007387; Expressed in thymus, kidney, colon, brain and testis. Expressed also by various hematopoietic and lymphoblastoid cell lines. Belongs to the MS4A family. Sequence=BAB18758.1; Type=Frameshift; Evidence=; protein binding membrane integral component of membrane uc008grk.1 uc008grk.2 uc008grk.3 
ENSMUST00000072751.13 Dohh ENSMUST00000072751.13 deoxyhypusine hydroxylase/monooxygenase (from RefSeq NM_133964.3) DOHH_MOUSE Dohh ENSMUST00000072751.1 ENSMUST00000072751.10 ENSMUST00000072751.11 ENSMUST00000072751.12 ENSMUST00000072751.2 ENSMUST00000072751.3 ENSMUST00000072751.4 ENSMUST00000072751.5 ENSMUST00000072751.6 ENSMUST00000072751.7 ENSMUST00000072751.8 ENSMUST00000072751.9 NM_133964 Q8BNT3 Q8BTD5 Q99LN9 uc007ghu.1 uc007ghu.2 uc007ghu.3 Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF- 5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. Reaction=[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]- hypusine + A + H2O; Xref=Rhea:RHEA:14101, Rhea:RHEA-COMP:10144, Rhea:RHEA-COMP:12592, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:82657, ChEBI:CHEBI:91175; EC=1.14.99.29; Evidence= Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence= Note=Binds 2 Fe(2+) ions per subunit. Protein modification; eIF5A hypusination. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99LN9-1; Sequence=Displayed; Name=2; IsoId=Q99LN9-2; Sequence=VSP_020315, VSP_020316; Embryonic lethal between E3.5 and E9.5. Belongs to the deoxyhypusine hydroxylase family. Sequence=BAC25064.1; Type=Frameshift; Evidence=; monooxygenase activity iron ion binding cellular_component peptidyl-lysine modification to peptidyl-hypusine oxidoreductase activity deoxyhypusine monooxygenase activity metal ion binding cofactor binding oxidation-reduction process uc007ghu.1 uc007ghu.2 uc007ghu.3 
ENSMUST00000072755.12 Col18a1 ENSMUST00000072755.12 Lacks conserved residue(s) required for the propagation of feature annotation. (from UniProt E9QPX1) BC043697 Col18a1 E9QPX1 E9QPX1_MOUSE ENSMUST00000072755.1 ENSMUST00000072755.10 ENSMUST00000072755.11 ENSMUST00000072755.2 ENSMUST00000072755.3 ENSMUST00000072755.4 ENSMUST00000072755.5 ENSMUST00000072755.6 ENSMUST00000072755.7 ENSMUST00000072755.8 ENSMUST00000072755.9 uc011xhb.1 uc011xhb.2 uc011xhb.3 Lacks conserved residue(s) required for the propagation of feature annotation. collagen trimer uc011xhb.1 uc011xhb.2 uc011xhb.3 
ENSMUST00000072769.7 Gm17494 ENSMUST00000072769.7 Gm17494 (from geneSymbol) AK138382 ENSMUST00000072769.1 ENSMUST00000072769.2 ENSMUST00000072769.3 ENSMUST00000072769.4 ENSMUST00000072769.5 ENSMUST00000072769.6 uc290jgl.1 uc290jgl.2 uc290jgl.1 uc290jgl.2 
ENSMUST00000072776.5 Cyp2d10 ENSMUST00000072776.5 cytochrome P450, family 2, subfamily d, polypeptide 10 (from RefSeq NM_010005.3) CP2DA_MOUSE Cyp2d-10 ENSMUST00000072776.1 ENSMUST00000072776.2 ENSMUST00000072776.3 ENSMUST00000072776.4 NM_010005 P24456 Q64490 uc007wzf.1 uc007wzf.2 uc007wzf.3 uc007wzf.4 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen arachidonic acid metabolic process heme binding organelle membrane exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc007wzf.1 uc007wzf.2 uc007wzf.3 uc007wzf.4 
ENSMUST00000072777.14 Hmga2 ENSMUST00000072777.14 high mobility group AT-hook 2, transcript variant 1 (from RefSeq NM_010441.3) ENSMUST00000072777.1 ENSMUST00000072777.10 ENSMUST00000072777.11 ENSMUST00000072777.12 ENSMUST00000072777.13 ENSMUST00000072777.2 ENSMUST00000072777.3 ENSMUST00000072777.4 ENSMUST00000072777.5 ENSMUST00000072777.6 ENSMUST00000072777.7 ENSMUST00000072777.8 ENSMUST00000072777.9 HMGA2_MOUSE Hmgic NM_010441 P52927 Q3UQW0 uc007hfb.1 uc007hfb.2 uc007hfb.3 Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (PubMed:27446912). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (By similarity). Interacts with E4F1 (By similarity). Interacts with NEK2 (PubMed:14668482). P52927; P06400: RB1; Xeno; NbExp=5; IntAct=EBI-912574, EBI-491274; Nucleus Expressed in mitotic spermatogonia, meiotic spermatocytes, and postmeiotic round spermatids (at protein level) (PubMed:14668482). Expressed in embryonic myogenic progenitor cells (PubMed:27446912). Expressed predominantly during embryogenesis. In myogenic progenitor cells, expressed during early myogenic development (11.5 dpc) to be gradually down-regulated during the fetal stages (17.5 dpc) (PubMed:27446912). Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. Phosphorylated by NEK2. Belongs to the HMGA family. negative regulation of transcription from RNA polymerase II promoter nuclear chromosome chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding epithelial to mesenchymal transition chondrocyte differentiation mesodermal-endodermal cell signaling DNA binding AT DNA binding DNA-(apurinic or apyrimidinic site) lyase activity protein binding nucleus base-excision repair regulation of transcription, DNA-templated cell cycle mitotic G2 DNA damage checkpoint signal transduction spermatogenesis positive regulation of cell proliferation DNA binding, bending male gonad development regulation of cell cycle process positive regulation of gene expression enzyme binding cell proliferation in forebrain pituitary gland development negative regulation of Wnt signaling pathway chromosome condensation adrenal gland development chromosome breakage nucleosomal DNA binding heterochromatin assembly protein-DNA complex negative regulation of intracellular steroid hormone receptor signaling pathway somatic stem cell population maintenance cAMP response element binding MH2 domain binding MH1 domain binding histone H2A-S139 phosphorylation senescence-associated heterochromatin focus senescence-associated heterochromatin focus assembly endodermal cell differentiation chondrocyte proliferation regulation of growth positive regulation of multicellular organism growth DNA damage response, detection of DNA damage positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of DNA binding negative regulation by host of viral transcription transcription regulatory region DNA binding fat cell differentiation positive regulation of angiogenesis negative regulation of single stranded viral RNA replication via double stranded DNA intermediate negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JAK-STAT cascade mesodermal cell differentiation negative regulation of astrocyte differentiation mesenchymal cell differentiation positive regulation of sequence-specific DNA binding transcription factor activity cell division meiotic cell cycle 5'-deoxyribose-5-phosphate lyase activity regulation of growth hormone secretion lung epithelium development epithelial tube branching involved in lung morphogenesis positive regulation of epithelial cell proliferation involved in lung morphogenesis adipose tissue development fat pad development C2H2 zinc finger domain binding SMAD protein complex positive regulation of cell cycle arrest positive regulation of cell proliferation in bone marrow positive regulation of protein serine/threonine kinase activity regulation of peptide hormone secretion oncogene-induced cell senescence regulation of stem cell population maintenance positive regulation of stem cell proliferation positive regulation of transcription regulatory region DNA binding positive regulation of cellular response to X-ray negative regulation of cellular senescence positive regulation of cellular senescence positive regulation of response to DNA damage stimulus negative regulation of double-strand break repair via nonhomologous end joining regulation of cellular response to drug uc007hfb.1 uc007hfb.2 uc007hfb.3 
ENSMUST00000072787.5 Vmn2r37 ENSMUST00000072787.5 vomeronasal 2, receptor 37 (from RefSeq NM_009489.2) ENSMUST00000072787.1 ENSMUST00000072787.2 ENSMUST00000072787.3 ENSMUST00000072787.4 F8VQD3 F8VQD3_MOUSE NM_009489 Vmn2r37 uc009fcu.1 uc009fcu.2 uc009fcu.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009fcu.1 uc009fcu.2 uc009fcu.3 
ENSMUST00000072801.5 Vmn1r82 ENSMUST00000072801.5 vomeronasal 1 receptor 82 (from RefSeq NM_134234.1) ENSMUST00000072801.1 ENSMUST00000072801.2 ENSMUST00000072801.3 ENSMUST00000072801.4 F6QZH4 NM_134234 Q8R283 Q8R283_MOUSE V1rg12 Vmn1r82 uc009fdx.1 uc009fdx.2 uc009fdx.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009fdx.1 uc009fdx.2 uc009fdx.3 
ENSMUST00000072804.11 Sox6 ENSMUST00000072804.11 SRY (sex determining region Y)-box 6, transcript variant 1 (from RefSeq NM_011445.5) ENSMUST00000072804.1 ENSMUST00000072804.10 ENSMUST00000072804.2 ENSMUST00000072804.3 ENSMUST00000072804.4 ENSMUST00000072804.5 ENSMUST00000072804.6 ENSMUST00000072804.7 ENSMUST00000072804.8 ENSMUST00000072804.9 NM_011445 Q3V1J7 Q3V1J7_MOUSE Sox6 uc009jiq.1 uc009jiq.2 uc009jiq.3 uc009jiq.4 This gene encodes a member of a family of transcriptional regulators containing high mobility group (HMG) DNA-binding domains. Function of the encoded protein is important for proper cardiac and skeletal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. Nucleus DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated positive regulation of chondrocyte differentiation astrocyte differentiation positive regulation of cartilage development cellular response to transforming growth factor beta stimulus negative regulation of cardiac muscle cell differentiation positive regulation of mesenchymal stem cell differentiation uc009jiq.1 uc009jiq.2 uc009jiq.3 uc009jiq.4 
ENSMUST00000072818.6 Ugt2b38 ENSMUST00000072818.6 UDP glucuronosyltransferase 2 family, polypeptide B38 (from RefSeq NM_133894.2) ENSMUST00000072818.1 ENSMUST00000072818.2 ENSMUST00000072818.3 ENSMUST00000072818.4 ENSMUST00000072818.5 NM_133894 Q91WH2 Q91WH2_MOUSE Ugt2b38 uc008xyi.1 uc008xyi.2 uc008xyi.3 uc008xyi.4 uc008xyi.5 nuclear outer membrane endoplasmic reticulum UDP-glycosyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring hexosyl groups intracellular membrane-bounded organelle uc008xyi.1 uc008xyi.2 uc008xyi.3 uc008xyi.4 uc008xyi.5 
ENSMUST00000072835.7 Ccdc112 ENSMUST00000072835.7 coiled-coil domain containing 112 (from RefSeq NM_001160399.1) Ccdc112 D3Z1J2 D3Z1J2_MOUSE ENSMUST00000072835.1 ENSMUST00000072835.2 ENSMUST00000072835.3 ENSMUST00000072835.4 ENSMUST00000072835.5 ENSMUST00000072835.6 NM_001160399 uc012bcr.1 uc012bcr.2 uc012bcr.1 uc012bcr.2 
ENSMUST00000072837.7 Foxk1 ENSMUST00000072837.7 forkhead box K1 (from RefSeq NM_199068.2) ENSMUST00000072837.1 ENSMUST00000072837.2 ENSMUST00000072837.3 ENSMUST00000072837.4 ENSMUST00000072837.5 ENSMUST00000072837.6 FOXK1_MOUSE Foxk1 Mnf NM_199068 O35939 P42128 Q3UHI6 Q3UN67 uc009aio.1 uc009aio.2 uc009aio.3 Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (PubMed:25402684, PubMed:29861159, PubMed:30700909). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:25402684, PubMed:29861159, PubMed:30700909). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (PubMed:30700909). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (PubMed:30700909). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (PubMed:30700909). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (PubMed:29861159). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (PubMed:25402684). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (PubMed:8007964, PubMed:9271401, PubMed:12446708, PubMed:22956541). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (PubMed:8007964, PubMed:9271401). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (PubMed:12446708, PubMed:22956541). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (PubMed:9271401, PubMed:22956541). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (PubMed:10792059). Represses myogenic differentiation by inhibiting MEFC activity (PubMed:22956541). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (By similarity). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (By similarity). Interacts with SIN3A and SIN3B (via PAH2) to form a complex which represses transcription (PubMed:10620510). Component of SIN3A-, but not SIN3B-, containing multiprotein complexes (PubMed:25402684). Interacts with FOXO4 and MEF2C; both interactions inhibit FOXO4 and MEF2C transactivation activity (PubMed:22956541). Interacts (when phosphorylated) with YWHAE/14-3-3-epsilon; promotes sequestration in the cytoplasm and leads to impaired ability to bind DNA (PubMed:29861159). Interacts with FHL2 (PubMed:20013826). Interacts with SRF (By similarity). Interacts with DVL2 and DVL3; the interaction induces DVL2 nuclear translocation (By similarity). Interacts with BAP1 (when phosphorylated) (By similarity). P42128; Q62141-2: Sin3b; NbExp=11; IntAct=EBI-878270, EBI-591466; Nucleus toplasm Note=Translocation to the nucleus is regulated by phosphorylation: phosphorylation by GSK3 (GSK3A or GSK3B) promotes interaction with 14- 3-3 proteins and sequestration in the cytoplasm (PubMed:29861159). Dephosphorylation promotes translocation to the nucleus (PubMed:29861159). Expressed in tissues and cells in which the myoglobin gene is transcriptionally active including cardiac and skeletal myocytes, brain and kidney (PubMed:8007964, PubMed:9271401). In the adult brain, expressed in the piriform cortex and the indusium griseum. In the hippocampus, expression is localized to the dentate gyrus and CA3 area (PubMed:16376864). In the cerebellum, expression is confined to the Purkinje cell layer (PubMed:16376864). Present in neuroretinal cells: expressed in rod bipolar cells, amacrine cells and ganglion cells (at protein level) (PubMed:23714736). Expressed at 13.5 dpc in developing muscle, limbs, trunk, and heart. Phosphorylation by GSK3 (GSK3A or GSK3B) promotes interaction with YWHAE/14-3-3-epsilon and retention in the cytoplasm (PubMed:29861159). In response to mTORC1 signaling, phosphorylation by GSK3 is prevented, leading to translocation to the nucleus (PubMed:29861159). Mutants exhibit a growth deficiency and a severe impairment in skeletal muscle regeneration following injury (PubMed:12446708, PubMed:10792059). They show atrophic skeletal muscles and their satellite cell function is impaired (PubMed:10792059). Double knockouts of CDKN1A and FOXK1 don't show significant differences compared to wild-type (PubMed:12446708). The mode of regulation of FOXK1 by mTORC1 is controversial. According to a first report, mTORC1 signaling promotes phosphorylation of FOXK1 and nuclear exclusion (PubMed:25402684). According to a second report, mTORC1 signaling prevents phosphorylation by GSK3 (GSK3A or GSK3B), thereby promoting translocation to the nucleus (PubMed:29861159). Sequence=AAA37529.1; Type=Frameshift; Evidence=; Sequence=AAB69641.1; Type=Frameshift; Evidence=; Sequence=BAE25880.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding cellular glucose homeostasis DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development muscle organ development negative regulation of autophagy regulation of glucose metabolic process cell differentiation negative regulation of cell growth regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter response to starvation sequence-specific DNA binding negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated canonical glycolysis 14-3-3 protein binding uc009aio.1 uc009aio.2 uc009aio.3 
ENSMUST00000072841.12 Eno3 ENSMUST00000072841.12 enolase 3, beta muscle, transcript variant 3 (from RefSeq NM_001276285.1) ENOB_MOUSE ENSMUST00000072841.1 ENSMUST00000072841.10 ENSMUST00000072841.11 ENSMUST00000072841.2 ENSMUST00000072841.3 ENSMUST00000072841.4 ENSMUST00000072841.5 ENSMUST00000072841.6 ENSMUST00000072841.7 ENSMUST00000072841.8 ENSMUST00000072841.9 Eno-3 NM_001276285 P21550 uc007jvx.1 uc007jvx.2 uc007jvx.3 uc007jvx.4 uc007jvx.5 This gene encodes one of the three enolase isoenzymes found in vertebrates. Enolase is a dimeric enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate as part of the glycolytic pathway. This isozyme is found in skeletal muscle where it is involved in muscle development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. Glycolytic enzyme that catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. Reaction=(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate; Xref=Rhea:RHEA:10164, ChEBI:CHEBI:15377, ChEBI:CHEBI:58289, ChEBI:CHEBI:58702; EC=4.2.1.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10165; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Mg(2+) is required for catalysis and for stabilizing the dimer.; Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 4/5. Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific. In vitro, interacts with several glycolytic enzymes including PKM, PGM, CKM and ALDO. Also binds PLG and troponin, in vitro. Interacts with PNKD (By similarity). Cytoplasm Note=Localized to the Z line. Some colocalization with CKM at M-band (By similarity). Brain (at protein level). The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. In striated muscle, the fiber-type order of ENO3 expression is IIB > IIX > IIA > I. During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells. In hindleg muscle, first expressed at 15 dpc after which, levels increase sharply between 15 dpc and 17 dpc. A steep prenatal rise in expression accompanies the formation of secondary myofibers and the development of innervation. High levels continue throughout newborn and adult stages. Beginning at postnatal day 5, a second sharp increase in expression correlates with the definitive specialization of the myofibers. Later in development, mainly expressed in fast-twitch fibers. In cardiac muscle, first expressed in the embryo in the cardiac tube. Levels decrease in degenerating myofibers, and increase with their regeneration. Belongs to the enolase family. phosphopyruvate hydratase complex magnesium ion binding phosphopyruvate hydratase activity cytoplasm cytosol plasma membrane glycolytic process aging membrane lyase activity response to drug protein homodimerization activity skeletal muscle tissue regeneration metal ion binding protein heterodimerization activity uc007jvx.1 uc007jvx.2 uc007jvx.3 uc007jvx.4 uc007jvx.5 
ENSMUST00000072854.2 Or1j12 ENSMUST00000072854.2 olfactory receptor family 1 subfamily J member 12 (from RefSeq NM_146951.1) ENSMUST00000072854.1 NM_146951 Olfr340 Or1j12 Q8VGL0 Q8VGL0_MOUSE uc008jlp.1 uc008jlp.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC109141.1, BC109142.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008jlp.1 uc008jlp.2 
ENSMUST00000072857.13 Scfd2 ENSMUST00000072857.13 Sec1 family domain containing 2, transcript variant a (from RefSeq NM_001114660.2) ENSMUST00000072857.1 ENSMUST00000072857.10 ENSMUST00000072857.11 ENSMUST00000072857.12 ENSMUST00000072857.2 ENSMUST00000072857.3 ENSMUST00000072857.4 ENSMUST00000072857.5 ENSMUST00000072857.6 ENSMUST00000072857.7 ENSMUST00000072857.8 ENSMUST00000072857.9 NM_001114660 Q3USN5 Q8BFV9 Q8BKU5 Q8BKZ0 Q8BTP6 Q8BTQ9 Q8BTY8 Q8BXI1 Q8BXS0 Q8BZ58 SCFD2_MOUSE Stxbp1l1 uc008xtk.1 uc008xtk.2 uc008xtk.3 uc008xtk.4 uc008xtk.5 May be involved in protein transport. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BTY8-1; Sequence=Displayed; Name=2; IsoId=Q8BTY8-2; Sequence=VSP_010714; Name=3; IsoId=Q8BTY8-3; Sequence=VSP_010712, VSP_010713; Name=4; IsoId=Q8BTY8-4; Sequence=VSP_010711, VSP_010712, VSP_010713; Belongs to the STXBP/unc-18/SEC1 family. Sequence=BAC32943.1; Type=Erroneous initiation; Evidence=; Sequence=BAC34373.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component vesicle docking involved in exocytosis biological_process protein transport vesicle-mediated transport uc008xtk.1 uc008xtk.2 uc008xtk.3 uc008xtk.4 uc008xtk.5 
ENSMUST00000072866.12 Ubap1 ENSMUST00000072866.12 ubiquitin-associated protein 1, transcript variant 1 (from RefSeq NM_023305.3) ENSMUST00000072866.1 ENSMUST00000072866.10 ENSMUST00000072866.11 ENSMUST00000072866.2 ENSMUST00000072866.3 ENSMUST00000072866.4 ENSMUST00000072866.5 ENSMUST00000072866.6 ENSMUST00000072866.7 ENSMUST00000072866.8 ENSMUST00000072866.9 NM_023305 Q8BH48 Q8BQ80 Q8BSW6 Q9D749 Q9ERV5 UBAP1_MOUSE Ubap1 uc008sin.1 uc008sin.2 uc008sin.3 Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (By similarity). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:31203368). Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with PTPN23. Interacts (via UBA domains) with ubiquitinated proteins. Cytoplasm, cytosol Endosome Note=Predominantly cytosolic. Recruited to endosomes as part of the ESCRT-I complex. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BH48-1; Sequence=Displayed; Name=2; IsoId=Q8BH48-2; Sequence=VSP_013651; Ubiquitous. Highly expressed in heart, liver, brain, kidney, spleen, skeletal muscle, stomach, testis and lung. The UMA domain mediates association with the ESCRT-I complex. Lethality by postnatal day 14 (PubMed:31203368). Conditional deletion in neurons impairs endosomal ubiquitin processing and promotes neurodegeneration (PubMed:31203368). Sequence=AAG09810.3; Type=Frameshift; Evidence=; Sequence=BAC26927.1; Type=Frameshift; Evidence=; ESCRT I complex cytoplasm endosome Golgi apparatus cytosol plasma membrane protein transport ubiquitin binding ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway uc008sin.1 uc008sin.2 uc008sin.3 
ENSMUST00000072868.5 Kcns2 ENSMUST00000072868.5 K+ voltage-gated channel, subfamily S, 2, transcript variant 1 (from RefSeq NM_181317.4) ENSMUST00000072868.1 ENSMUST00000072868.2 ENSMUST00000072868.3 ENSMUST00000072868.4 KCNS2_MOUSE NM_181317 O35174 Q543P3 uc007vly.1 uc007vly.2 uc007vly.3 Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed:9305895). Heterotetramer with KCNB1 and KCNB2 (PubMed:9305895). Does not form homomultimers (PubMed:9305895). Cell membrane ; Multi-pass membrane protein Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2 (PubMed:9305895). Detected in brain, but not in the other tissues tested. Expression was highest in the olfactory bulb, cerebral cortex, hippocampus, habenula, basolateral amygdaloid nuclei and cerebellum (PubMed:9305895). The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane regulation of ion transmembrane transport perinuclear region of cytoplasm protein homooligomerization transmembrane transport potassium ion transmembrane transport regulation of delayed rectifier potassium channel activity uc007vly.1 uc007vly.2 uc007vly.3 
ENSMUST00000072875.15 Srsf11 ENSMUST00000072875.15 serine and arginine-rich splicing factor 11, transcript variant 16 (from RefSeq NR_166766.1) ENSMUST00000072875.1 ENSMUST00000072875.10 ENSMUST00000072875.11 ENSMUST00000072875.12 ENSMUST00000072875.13 ENSMUST00000072875.14 ENSMUST00000072875.2 ENSMUST00000072875.3 ENSMUST00000072875.4 ENSMUST00000072875.5 ENSMUST00000072875.6 ENSMUST00000072875.7 ENSMUST00000072875.8 ENSMUST00000072875.9 NR_166766 Q3UIX4 Q3UIX4_MOUSE Sfrs11 Srsf11 uc008rvn.1 uc008rvn.2 uc008rvn.3 The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]. ##Evidence-Data-START## Transcript exon combination :: SRR6238556.1017902.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## nucleic acid binding RNA binding nucleoplasm biological_process RNA splicing nuclear speck uc008rvn.1 uc008rvn.2 uc008rvn.3 
ENSMUST00000072886.11 Sctr ENSMUST00000072886.11 secretin receptor, transcript variant 1 (from RefSeq NM_001012322.2) ENSMUST00000072886.1 ENSMUST00000072886.10 ENSMUST00000072886.2 ENSMUST00000072886.3 ENSMUST00000072886.4 ENSMUST00000072886.5 ENSMUST00000072886.6 ENSMUST00000072886.7 ENSMUST00000072886.8 ENSMUST00000072886.9 H7BX37 H7BX37_MOUSE NM_001012322 Sctr uc007cjb.1 uc007cjb.2 uc007cjb.3 uc007cjb.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 2 family. transmembrane signaling receptor activity G-protein coupled receptor activity cytoplasmic microtubule signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway secretin receptor activity membrane integral component of membrane peptide hormone binding uc007cjb.1 uc007cjb.2 uc007cjb.3 uc007cjb.4 
ENSMUST00000072887.5 Or52n1 ENSMUST00000072887.5 Or52n1 (from geneSymbol) ENSMUST00000072887.1 ENSMUST00000072887.2 ENSMUST00000072887.3 ENSMUST00000072887.4 NR_190745 uc291tuz.1 uc291tuz.2 uc291tuz.1 uc291tuz.2 
ENSMUST00000072889.12 Carmil1 ENSMUST00000072889.12 capping protein regulator and myosin 1 linker 1, transcript variant 1 (from RefSeq NM_026825.3) CARL1_MOUSE Carmil Carmil1 ENSMUST00000072889.1 ENSMUST00000072889.10 ENSMUST00000072889.11 ENSMUST00000072889.2 ENSMUST00000072889.3 ENSMUST00000072889.4 ENSMUST00000072889.5 ENSMUST00000072889.6 ENSMUST00000072889.7 ENSMUST00000072889.8 ENSMUST00000072889.9 Lrrc16 Lrrc16a NM_026825 Q5NCM0 Q6EDY6 Q8BQ45 Q8BRS5 Q91YZ6 uc007pvn.1 uc007pvn.2 uc007pvn.3 uc007pvn.4 Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:16054028). Homodimer (By similarity). Interacts (via C-terminus) with heterodimeric capping protein (CP); this interaction uncaps barbed ends capped by CP, enhances barbed-end actin polymerization and promotes lamellipodial formation and cell migration (PubMed:16054028). Interacts with MYO1E (By similarity). Interacts with TRIO (By similarity). Cytoplasm Cytoplasm, cytoskeleton Cell membrane Cell projection, lamellipodium Note=Found on macropinosomes (By similarity). Colocalized with heterodimeric capping protein (CP) and F- actin in lamellipodia but not with F-actin in stress fibers (PubMed:16054028). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6EDY6-1; Sequence=Displayed; Name=2; IsoId=Q6EDY6-2; Sequence=VSP_032421, VSP_032422; Name=3; IsoId=Q6EDY6-3; Sequence=VSP_032423, VSP_032424; The C-terminus is necessary for localization to the cell membrane. [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the CARMIL family. Sequence=AAH12229.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC31591.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleus cytoplasm cytosol cytoskeleton plasma membrane establishment or maintenance of cell polarity membrane cell migration nuclear speck lamellipodium lamellipodium assembly positive regulation of cell migration positive regulation of actin filament polymerization cell leading edge ruffle organization filamentous actin cell projection macropinocytosis macropinosome macromolecular complex binding intermediate filament cytoskeleton urate metabolic process positive regulation of stress fiber assembly barbed-end actin filament uncapping actin filament network formation positive regulation of substrate adhesion-dependent cell spreading positive regulation of lamellipodium organization negative regulation of barbed-end actin filament capping uc007pvn.1 uc007pvn.2 uc007pvn.3 uc007pvn.4 
ENSMUST00000072895.10 Gm14393 ENSMUST00000072895.10 predicted gene 14393 (from RefSeq NM_001085546.2) A2ARW5 A2ARW5_MOUSE ENSMUST00000072895.1 ENSMUST00000072895.2 ENSMUST00000072895.3 ENSMUST00000072895.4 ENSMUST00000072895.5 ENSMUST00000072895.6 ENSMUST00000072895.7 ENSMUST00000072895.8 ENSMUST00000072895.9 Gm14393 NM_001085546 uc008ofj.1 uc008ofj.2 uc008ofj.3 uc008ofj.4 Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008ofj.1 uc008ofj.2 uc008ofj.3 uc008ofj.4 
ENSMUST00000072896.13 Armc10 ENSMUST00000072896.13 armadillo repeat containing 10, transcript variant 1 (from RefSeq NM_026034.5) ARM10_MOUSE ENSMUST00000072896.1 ENSMUST00000072896.10 ENSMUST00000072896.11 ENSMUST00000072896.12 ENSMUST00000072896.2 ENSMUST00000072896.3 ENSMUST00000072896.4 ENSMUST00000072896.5 ENSMUST00000072896.6 ENSMUST00000072896.7 ENSMUST00000072896.8 ENSMUST00000072896.9 NM_026034 Q80ZY2 Q9CUN3 Q9CZ87 Q9D0L7 uc008wos.1 uc008wos.2 uc008wos.3 May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53 (By similarity). Interacts with the DNA-binding domain of p53/TP53. Endoplasmic reticulum membrane ; Single-pass membrane protein Mitochondrion outer membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D0L7-1; Sequence=Displayed; Name=2; IsoId=Q9D0L7-2; Sequence=VSP_027363; Sequence=BAB29775.1; Type=Frameshift; Evidence=; p53 binding mitochondrion endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane regulation of growth positive regulation of growth rate negative regulation of apoptotic process DBD domain binding negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator uc008wos.1 uc008wos.2 uc008wos.3 
ENSMUST00000072899.9 Cgnl1 ENSMUST00000072899.9 cingulin-like 1, transcript variant 2 (from RefSeq NM_026599.6) B2RSU6 CGNL1_MOUSE Cgnl1 ENSMUST00000072899.1 ENSMUST00000072899.2 ENSMUST00000072899.3 ENSMUST00000072899.4 ENSMUST00000072899.5 ENSMUST00000072899.6 ENSMUST00000072899.7 ENSMUST00000072899.8 Jacop Kiaa1749 NM_026599 Q5U5U0 Q69ZB4 Q6AW69 Q8BLZ5 Q8BZ26 Q9D2T3 uc009qpc.1 uc009qpc.2 uc009qpc.3 uc009qpc.4 This gene encodes a protein localized to the tight junctions and adherens junctions in vertebrate epithelial cells. The encoded protein regulates the activity of Rho family GTPases during junction assembly and at confluence. At the adherens junctions, the encoded protein is part of a protein complex that links E-cadherin to the microtubule cytoskeleton. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. Homodimer or oligomer (Probable). Interacts with CD2AP and SH3BP1; probably part of a complex at cell junctions (By similarity). Cell junction, tight junction Note=Localizes to the apical junction complex composed of tight and adherens junctions. In the liver and kidney, it is also found along non-junctional actin filament bundles in addition to the apical junction. Event=Alternative splicing; Named isoforms=3; Name=4; IsoId=Q6AW69-4; Sequence=Displayed; Name=3; IsoId=Q6AW69-3; Sequence=VSP_061744; Name=5; IsoId=Q6AW69-5; Sequence=VSP_061743; Widely expressed. Highly expressed in the kidney and lung. The head region is responsible for both junction and actin filament-based distribution. Belongs to the cingulin family. Sequence=AAH31499.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB31463.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; molecular_function motor activity bicellular tight junction actin filament organization actin cytoskeleton myosin complex cell junction apical junction complex negative regulation of small GTPase mediated signal transduction uc009qpc.1 uc009qpc.2 uc009qpc.3 uc009qpc.4 
ENSMUST00000072910.6 Chadl ENSMUST00000072910.6 chondroadherin-like (from RefSeq NM_001164320.1) CHADL_MOUSE E9Q7T7 ENSMUST00000072910.1 ENSMUST00000072910.2 ENSMUST00000072910.3 ENSMUST00000072910.4 ENSMUST00000072910.5 NM_001164320 SLRR4B uc007wwy.1 uc007wwy.2 uc007wwy.3 uc007wwy.4 uc007wwy.5 Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment. Associates with collagen and binds to collagen fibrils. Secreted, extracellular space, extracellular matrix Expressed in cartilage, including articular knee cartilage, where it localizes to the extracellular space in the area immediately surrounding the chondrocytes, not detected in any other tissues (at protein level). Not detected before 13.5 dpc. From 13.5 dpc on, prominently expressed only in mesenchymal condensations and in cartilaginous tissues. In the ATDC5 cell line model, up-regulated during chondrocyte differentiation, absent in precondrogenic, non- differentiating stage (at protein level). Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily. collagen binding extracellular region extracellular space extracellular matrix negative regulation of chondrocyte differentiation collagen fibril binding negative regulation of collagen fibril organization uc007wwy.1 uc007wwy.2 uc007wwy.3 uc007wwy.4 uc007wwy.5 
ENSMUST00000072914.3 Or5p80 ENSMUST00000072914.3 olfactory receptor family 5 subfamily P member 80 (from RefSeq NM_146773.1) ENSMUST00000072914.1 ENSMUST00000072914.2 Mor204-6 NM_146773 O5P80_MOUSE Olfr508 Or5p80 Q8VG42 uc009jcr.1 uc009jcr.2 uc009jcr.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC130241.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jcr.1 uc009jcr.2 uc009jcr.3 
ENSMUST00000072915.4 Foxb2 ENSMUST00000072915.4 forkhead box B2 (from RefSeq NM_008023.2) ENSMUST00000072915.1 ENSMUST00000072915.2 ENSMUST00000072915.3 FOXB2_MOUSE Fkh4 NM_008023 Q64733 uc008gxc.1 uc008gxc.2 uc008gxc.3 Transcription factor. Nucleus Expressed during embryogenesis. RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter anatomical structure morphogenesis cell differentiation sequence-specific DNA binding uc008gxc.1 uc008gxc.2 uc008gxc.3 
ENSMUST00000072916.5 Zswim7 ENSMUST00000072916.5 zinc finger SWIM-type containing 7 (from RefSeq NM_027198.1) ENSMUST00000072916.1 ENSMUST00000072916.2 ENSMUST00000072916.3 ENSMUST00000072916.4 NM_027198 Q9CWQ2 Sws1 ZSWM7_MOUSE uc007jip.1 uc007jip.2 uc007jip.3 uc007jip.4 Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents (By similarity). Required for meiotic progression, hence for fertility (PubMed:33713115). Interacts with RAD51D and XRCC3; involved in homologous recombination repair. Interacts with SWSAP1; they form a functional complex involved in homologous recombination repair and stabilize each other (By similarity). Nucleus Belongs to the SWS1 family. double-strand break repair via homologous recombination molecular_function nucleus DNA repair DNA recombination cellular response to DNA damage stimulus zinc ion binding metal ion binding protein stabilization Shu complex uc007jip.1 uc007jip.2 uc007jip.3 uc007jip.4 
ENSMUST00000072943.5 Prl7c1 ENSMUST00000072943.5 prolactin family 7, subfamily c, member 1, transcript variant 1 (from RefSeq NM_026206.3) ENSMUST00000072943.1 ENSMUST00000072943.2 ENSMUST00000072943.3 ENSMUST00000072943.4 NM_026206 PR7C1_MOUSE Prlpo Q9CRB5 uc007pyd.1 uc007pyd.2 Secreted Expressed exclusively in the placenta. Expressed in spongiotrophoblast cells and trophoblast giant cells of the junctional zone and in labyrinthine trophoblast. Detectable throughout the second half of gestation. Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pyd.1 uc007pyd.2 
ENSMUST00000072948.11 Acox1 ENSMUST00000072948.11 acyl-Coenzyme A oxidase 1, palmitoyl, transcript variant 4 (from RefSeq NM_001377522.1) A2A850 ACOX1_MOUSE Acox Acox1 ENSMUST00000072948.1 ENSMUST00000072948.10 ENSMUST00000072948.2 ENSMUST00000072948.3 ENSMUST00000072948.4 ENSMUST00000072948.5 ENSMUST00000072948.6 ENSMUST00000072948.7 ENSMUST00000072948.8 ENSMUST00000072948.9 NM_001377522 O35616 Paox Q3TDG0 Q8BYC3 Q9R0H0 uc007mkm.1 uc007mkm.2 uc007mkm.3 uc007mkm.4 This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.3412197.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long- chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl- CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)). [Isoform 1]: Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro. [Isoform 2]: Is active against a much broader range of substrates and shows activity towards long-chain acyl-CoAs. Reaction=a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2; Xref=Rhea:RHEA:38959, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:58856, ChEBI:CHEBI:65111; EC=1.3.3.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38960; Evidence=; Reaction=hexadecanoyl-CoA + O2 = (2E)-hexadecenoyl-CoA + H2O2; Xref=Rhea:RHEA:40167, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57379, ChEBI:CHEBI:61526; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40168; Evidence=; Reaction=dodecanoyl-CoA + O2 = (2E)-dodecenoyl-CoA + H2O2; Xref=Rhea:RHEA:40171, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57330, ChEBI:CHEBI:57375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40172; Evidence=; Reaction=O2 + octanoyl-CoA = (2E)-octenoyl-CoA + H2O2; Xref=Rhea:RHEA:40175, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57386, ChEBI:CHEBI:62242; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40176; Evidence=; Reaction=decanoyl-CoA + O2 = (2E)-decenoyl-CoA + H2O2; Xref=Rhea:RHEA:40179, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:61406, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40180; Evidence=; Reaction=O2 + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O2; Xref=Rhea:RHEA:40183, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57385, ChEBI:CHEBI:61405; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40184; Evidence=; Reaction=hexadecanedioyl-CoA + O2 = (2E)-hexadecenedioyl-CoA + H2O2; Xref=Rhea:RHEA:40275, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:77075, ChEBI:CHEBI:77085; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40276; Evidence=; Reaction=O2 + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O2; Xref=Rhea:RHEA:40319, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:65052, ChEBI:CHEBI:74693; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40320; Evidence=; Reaction=glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2; Xref=Rhea:RHEA:40315, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57353, ChEBI:CHEBI:57378; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40316; Evidence=; Reaction=hexanoyl-CoA + O2 = (2E)-hexenoyl-CoA + H2O2; Xref=Rhea:RHEA:40311, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:62077, ChEBI:CHEBI:62620; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40312; Evidence=; Reaction=O2 + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O2; Xref=Rhea:RHEA:38971, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57394, ChEBI:CHEBI:71412; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38972; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2; Xref=Rhea:RHEA:69643, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:73862, ChEBI:CHEBI:187901; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69644; Evidence=; Reaction=(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2; Xref=Rhea:RHEA:39119, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:74086, ChEBI:CHEBI:76360; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39120; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Lipid metabolism; peroxisomal fatty acid beta-oxidation. Homodimer (By similarity). Interacts with LONP2 (By similarity). Peroxisome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9R0H0-1; Sequence=Displayed; Name=2; IsoId=Q9R0H0-2; Sequence=VSP_042477; Highest levels of isoform 1 are found in liver and kidney while highest levels of isoform 2 are found in white adipose tissue. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 is expressed at higher levels in brain, heart, lung, muscle, white adipose tissue and testis. Severe microvesicular hepatic steatosis, sustained activation of Ppara, spontaneous massive peroxisome proliferation and eventual development of hepatocellular carcinomas (PubMed:20195242). Null mice have strikingly increased levels of both n-3 and n-6 very long chain polyunsaturated fatty acids (over twenty- four (24) carbons long) (PubMed:11855929). Belongs to the acyl-CoA oxidase family. Sequence=BAE41642.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; very long-chain fatty acid metabolic process acyl-CoA oxidase activity fatty acid binding nucleus nucleoplasm nucleolus cytoplasm mitochondrion peroxisome peroxisomal membrane cytosol plasma membrane generation of precursor metabolites and energy lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation prostaglandin metabolic process spermatogenesis palmitoyl-CoA oxidase activity oxidoreductase activity peroxisome fission oxidoreductase activity, acting on the CH-CH group of donors fatty acid oxidation PDZ domain binding fatty acid beta-oxidation using acyl-CoA oxidase cholesterol homeostasis protein homodimerization activity intracellular membrane-bounded organelle protein N-terminus binding flavin adenine dinucleotide binding lipid homeostasis oxidation-reduction process FAD binding uc007mkm.1 uc007mkm.2 uc007mkm.3 uc007mkm.4 
ENSMUST00000072954.8 Lancl2 ENSMUST00000072954.8 Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. (from UniProt Q9JJK2) BC016072 ENSMUST00000072954.1 ENSMUST00000072954.2 ENSMUST00000072954.3 ENSMUST00000072954.4 ENSMUST00000072954.5 ENSMUST00000072954.6 ENSMUST00000072954.7 LANC2_MOUSE Q9JJK2 Tasp uc291euw.1 uc291euw.2 Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4- phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP- binding enhances membrane association. Nucleus Cytoplasm Cell membrane Note=Localizes to the juxta-nuclear vesicles. Associates with the cortical actin cytoskeleton. Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo. Myristoylated. Essential for membrane association. Belongs to the LanC-like protein family. catalytic activity nucleus cytoplasm cytosol plasma membrane positive regulation of abscisic acid-activated signaling pathway phosphatidylinositol-5-phosphate binding membrane cortical actin cytoskeleton phosphatidylinositol-3-phosphate binding negative regulation of transcription, DNA-templated phosphatidylinositol-4-phosphate binding uc291euw.1 uc291euw.2 
ENSMUST00000072961.6 Vps41 ENSMUST00000072961.6 VPS41 HOPS complex subunit (from RefSeq NM_172120.4) ENSMUST00000072961.1 ENSMUST00000072961.2 ENSMUST00000072961.3 ENSMUST00000072961.4 ENSMUST00000072961.5 NM_172120 Q05AE9 Q3TPS1 Q5KU39 Q80V99 Q8BKK6 Q8CG01 Q8CJC3 VPS41_MOUSE uc007pok.1 uc007pok.2 uc007pok.3 uc007pok.4 Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo. Required for fusion of autophagosomes with lysosomes. Links the HOPS complex to endosomal via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (By similarity). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (By similarity). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (By similarity). Component of the putative homotypic fusion and vacuole protein sorting (HOPS) complex; the core of which composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, is associated with VPS39 and VPS41. Interacts with RILP, MON1B. Interacts with ARL8B (GTP-bound form); involved in recruitment to lysosomes and probably hierarchial assembly of the HOPS complex at lysosomal membranes. In vitro can self- assemble into a lattice. Associates with adapter protein complex 3 (AP- 3) and clathrin:AP-3 complexes. Interacts with STX17; this interaction is increased in the absence of TMEM39A. Interacts with ARL8B and PLEKHM1; the interaction mediates the recruitment of the HOPS complex to lysosomes. Endosome membrane ; Peripheral membrane protein Late endosome membrane ; Peripheral membrane protein Early endosome membrane ; Peripheral membrane protein Lysosome membrane ; Peripheral membrane protein Golgi apparatus, trans-Golgi network Cytoplasmic vesicle, clathrin-coated vesicle Cytoplasm, cytosol Belongs to the VPS41 family. protein binding lysosome lysosomal membrane endosome early endosome late endosome Golgi apparatus Golgi-associated vesicle cytosol intracellular protein transport autophagy microtubule binding endosome to lysosome transport endosome membrane protein transport microtubule cytoskeleton membrane vesicle-mediated transport AP-3 adaptor complex clathrin-coated vesicle HOPS complex cytoplasmic vesicle late endosome membrane endosomal vesicle fusion regulation of SNARE complex assembly vacuole fusion, non-autophagic identical protein binding protein self-association regulated exocytosis metal ion binding intracellular transport Golgi vesicle transport clathrin complex late endosome to lysosome transport uc007pok.1 uc007pok.2 uc007pok.3 uc007pok.4 
ENSMUST00000072965.5 Sirt2 ENSMUST00000072965.5 sirtuin 2, transcript variant 1 (from RefSeq NM_022432.5) E9PXF5 ENSMUST00000072965.1 ENSMUST00000072965.2 ENSMUST00000072965.3 ENSMUST00000072965.4 NM_022432 Q8VDQ8 Q9CXS5 Q9EQ18 Q9ERJ9 SIR2_MOUSE Sir2l2 U5TP50 uc009fzt.1 uc009fzt.2 uc009fzt.3 uc009fzt.4 NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:17521387, PubMed:17681146, PubMed:17574768, PubMed:19037106, PubMed:22014574, PubMed:21791548, PubMed:21841822, PubMed:24334550). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression. Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response. Deacetylates also histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition. During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter and thereby contributes to regulate expression of VEGFA, a key regulator of angiogenesis. Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells (PubMed:17574768, PubMed:21791548). Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination. Involved in several cellular metabolic pathways. Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability. Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6- phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage. Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis. Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity (PubMed:17681146, PubMed:19037106). Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells (PubMed:17681146, PubMed:19037106). Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy (PubMed:17681146, PubMed:19037106). Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation (PubMed:17521387, PubMed:21841822). Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia. Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation. Inhibits transcriptional activation by deacetylating p53/TP53 and EP300. Deacetylates also EIF5A. Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions. Plays a role as tumor suppressor (PubMed:22014574, PubMed:23468428). In addition to protein deacetylase activity, also has activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as ARF6 and KRAS, thereby regulating their association with membranes (By similarity). [Isoform 1]: Deacetylates alpha-tubulin. [Isoform 2]: Deacetylates alpha-tubulin. [Isoform 4]: Deacetylates alpha-tubulin. Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286; Evidence= Reaction=H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O- tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:70567, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:15437, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:141129, ChEBI:CHEBI:189674; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70568; Evidence=; Reaction=H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O- hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:70563, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:14175, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:138936, ChEBI:CHEBI:189673; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70564; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide. Inhibited by a macrocyclic peptide inhibitor S2iL5. Inhibited by EP300-induced acetylation (By similarity). Interacts with CDC20, FOXO3 and FZR1 (PubMed:17521387, PubMed:22014574). Associates with microtubule in primary cortical mature neurons (By similarity). Homotrimer. Interacts (via both phosphorylated, unphosphorylated, active or inactive forms) with HDAC6; the interaction is necessary for the complex to interact with alpha- tubulin, suggesting that these proteins belong to a large complex that deacetylates the cytoskeleton. Interacts with FOXO1; the interaction is disrupted upon serum-starvation or oxidative stress, leading to increased level of acetylated FOXO1 and induction of autophagy (PubMed:17681146, PubMed:19037106). Interacts with RELA; the interaction occurs in the cytoplasm and is increased in a TNF-alpha- dependent manner. Interacts with HOXA10; the interaction is direct. Interacts with YWHAB and YWHAG; the interactions occur in a AKT- dependent manner and increase SIRT2-dependent TP53 deacetylation. Interacts with MAPK1/ERK2 and MAPK3/ERK1; the interactions increase SIRT2 stability and deacetylation activity. Interacts (phosphorylated form) with KMT5A isoform 2; the interaction is direct, stimulates KMT5A-mediated methyltransferase activity on histone at 'Lys-20' (H4K20me1) and is increased in a H(2)O(2)-induced oxidative stress- dependent manner. Interacts with G6PD; the interaction is enhanced by H(2)O(2) treatment. Interacts with a G1/S-specific cyclin E-CDK2 complex. Interacts with AURKA, CDK5R1 (p35 form) and CDK5 and HIF1A. Interacts with the tRNA ligase SARS1; recruited to the VEGFA promoter via interaction with SARS1 (By similarity). Isoform 2 and isoform 4 associate with microtubules in primary cortical mature neurons. Interacts with BEX4; negatively regulates alpha-tubulin deacetylation by SIRT2 (By similarity). Q8VDQ8; Q9JJ66: Cdc20; NbExp=2; IntAct=EBI-911012, EBI-2551389; Q8VDQ8; Q9R1K5: Fzr1; NbExp=2; IntAct=EBI-911012, EBI-5238560; Q8VDQ8; O14965: AURKA; Xeno; NbExp=5; IntAct=EBI-911012, EBI-448680; Nucleus toplasm toplasm, perinuclear region Perikaryon Cytoplasm, cytoskeleton Cell projection Cell projection, growth cone Myelin membrane Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Chromosome Midbody Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localizes in the cytoplasm during most of the cell cycle except in the G2/M transition and during mitosis, where it is localized in association with chromatin and induces deacetylation of histone at 'Lys-16' (H4K16ac). Colocalizes with KMT5A at mitotic foci. Colocalizes with CDK1 at centrosome during prophase and splindle fibers during metaphase. Colocalizes with Aurora kinase AURKA at centrosome during early prophase and in the centrioles and growing mitotic spindle throughout metaphase. Colocalizes with Aurora kinase AURKB during cytokinesis with the midbody. Colocalizes with microtubules (By similarity). Deacetylates FOXO3 in the cytoplasm (PubMed:17521387). Colocalizes with PLP1 in internodal regions of myelin sheat, at paranodal axoglial junction and Schmidt-Lanterman incisures (PubMed:16933150). Colocalizes with CDK5R1 in the perikaryon, neurites and growth cone of hippocampal neurons (PubMed:16933150). Colocalizes with alpha-tubulin in neuronal growth cone (PubMed:18332217). Localizes in the cytoplasm and nucleus of germinal vesicle (GV) stage oocytes (PubMed:24334550). Colocalizes with alpha- tubulin on the meiotic spindle as the oocytes enter into metaphase, and also during meiotic anaphase and telophase, especially with the midbody (PubMed:24334550). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=SIRT2.1; IsoId=Q8VDQ8-1; Sequence=Displayed; Name=2; Synonyms=SIRT2.2; IsoId=Q8VDQ8-2; Sequence=VSP_008729; Name=3; IsoId=Q8VDQ8-3; Sequence=VSP_055330; Name=4; Synonyms=SIRT2.3; IsoId=Q8VDQ8-4; Sequence=VSP_055329; Isoform 1 is weakly expressed in the cortex at postnatal(P) days P1, P3 and P7, and increases progressively between P17 and older adult cortex. Isoform 1 is also expressed in heart, liver and skeletal muscle, weakly expressed in the striatum and spinal cord. Isoform 2 is not expressed in the cortex at P1, P3 and P7, and increases strongly and progressively between P17 and older adult cortex. Isoform 2 is also expressed in the heart, liver, striatum and spinal cord. Isoform 4 is weakly expressed in older adult cortex and spinal cords. Expressed in the cortex. Expressed in postnatal sciatic nerves during myelination and during remyelination after nerve injury. Expressed in neurons, oligodendrocytes, Schwann cells, Purkinje cells and in astrocytes of white matter. Strongly expressed in preadipocytes compared with differentiated adipocytes. Expressed in cerebellar granule cells. Expressed in the inner ear: in the cochlea, expressed in types I and V fibrocytes in the spiral ligament (SL) and slightly in stria vascularis (SV); in the organ of Corti, expressed in some supporting cells; in the crista ampullaris, expressed in spiral ganglion cells; also expressed in the endolymphatic sac (ES) epithelial cells (at protein level). Expressed in the brain, spinal cord, optic nerve and hippocampus. Strongly expressed in 6-8 week-old ovulated meiosis II oocytes and weakly expressed in 45-58 week-old ovulated meiosis II oocytes. Expressed in the cochlea, vestibule and acoustic nerve of the inner ear. Isoform 1 is expressed in the cortex at 15.5 dpc. Isoform 2 is not detected in the cortex at 15.5 dpc (at protein level). Up-regulated in response to caloric restriction in white and brown adipose tissues. Up-regulated during cold exposure and down- regulated in higher ambient temperature in brown adipose tissue. Up- regulated after beta-adrenergic agonist (isoproterenol) treatment in white adipose tissue (at protein level). Up-regulated in response to caloric restriction in adipose tissue and kidney. Up-regulated in response to oxidative stress. Up-regulated during postnatal sciatic nerve myelination development and axonal regeneration. Down-regulated during preadipocyte differentiation. Down-regulated in Schwann dedifferentiated cells during Wallerian degeneration. Isoform 1 is up- regulated upon differentiation to a neuron-like phenotype. Phosphorylated at phosphoserine and phosphothreonine. Phosphorylated at Ser-368 by a mitotic kinase CDK1/cyclin B at the G2/M transition; phosphorylation regulates the delay in cell-cycle progression. Phosphorylated at Ser-368 by a mitotic kinase G1/S- specific cyclin E/Cdk2 complex; phosphorylation inactivates SIRT2- mediated alpha-tubulin deacetylation and thereby negatively regulates cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Phosphorylated by cyclin A/Cdk2 and p35-Cdk5 complexes and to a lesser extent by the cyclin D3/Cdk4 and cyclin B/Cdk1, in vitro. Dephosphorylated at Ser-368 by CDC14A and CDC14B around early anaphase (By similarity). Acetylated by EP300; acetylation leads both to the decreased of SIRT2-mediated alpha-tubulin deacetylase activity and SIRT2-mediated down-regulation of TP53 transcriptional activity. Ubiquitinated. Tissue-specific knockout of SIRT2 in Schwann cells of early postnatal mice leads to a transient delay in myelination, a reduction in the nerve conduction velocity and hyperacetylation of PARD3. The number of dividing Schwann cells in the developing nerve and alpha-tubulin acetylation are normal (PubMed:21949390). Mutant mice embryo grow normally and new born are healthy. Embryonic fibroblasts (MEFs) display reduced cell proliferation capacity, centrosome amplification and mitotic cell death. Nude mice inoculated with immortalized MEFs from mutant mice developed tumors. Adult mutant mice exhibit genomic instability and chromosomal aberrations, such as double-strand breaks (DSBs), with a gender-specific spectrum of tumorigenesis; females develop primarily mammary tumors and males develop tumors in several organs, including the liver, lung, pancreas, stomach, duodenum and prostate. Drastic increases of histone H4K16 acetylation and decreases of both histone methylation (H4K20me1) in metaphasic chromosomes and histone methylations (H4K20me2/3) in late M/early G1 but also throughout all phases of the cell cycle (PubMed:23468428). Belongs to the sirtuin family. Class I subfamily. negative regulation of transcription from RNA polymerase II promoter chromatin binding NAD+ ADP-ribosyltransferase activity histone deacetylase activity protein binding nucleus chromosome nuclear heterochromatin nucleolus cytoplasm mitochondrion centrosome centriole microtubule organizing center spindle cytosol cytoskeleton microtubule plasma membrane protein ADP-ribosylation protein deacetylation autophagy cell cycle nervous system development transcription factor binding zinc ion binding negative regulation of cell proliferation negative regulation of autophagy negative regulation of peptidyl-threonine phosphorylation phosphatidylinositol 3-kinase signaling membrane histone deacetylation hydrolase activity NAD-dependent histone deacetylase activity myelination in peripheral nervous system cell differentiation growth cone midbody regulation of myelination positive regulation of proteasomal ubiquitin-dependent protein catabolic process paranodal junction paranode region of axon protein deacetylase activity cellular response to oxidative stress NAD-dependent protein deacetylase activity peptidyl-lysine deacetylation histone acetyltransferase binding cellular response to hepatocyte growth factor stimulus myelin sheath abaxonal region negative regulation of protein catabolic process histone deacetylase binding tubulin deacetylase activity cell projection negative regulation of apoptotic process ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process perikaryon myelin sheath lateral loop Schmidt-Lanterman incisure positive regulation of DNA binding protein kinase B signaling juxtaparanode region of axon cellular lipid catabolic process regulation of fat cell differentiation negative regulation of fat cell differentiation positive regulation of meiotic nuclear division negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding NAD-dependent histone deacetylase activity (H4-K16 specific) hepatocyte growth factor receptor signaling pathway perinuclear region of cytoplasm negative regulation of oligodendrocyte differentiation cell division meiotic cell cycle regulation of cell cycle positive regulation of cell division positive regulation of attachment of spindle microtubules to kinetochore negative regulation of transcription from RNA polymerase II promoter in response to hypoxia cellular response to caloric restriction NAD+ binding negative regulation of oligodendrocyte progenitor proliferation histone H3 deacetylation histone H4 deacetylation cellular response to molecule of bacterial origin cellular response to hypoxia cellular response to epinephrine stimulus mitotic spindle meiotic spindle tubulin deacetylation glial cell projection terminal loop glutamatergic synapse positive regulation of execution phase of apoptosis positive regulation of oocyte maturation negative regulation of NLRP3 inflammasome complex assembly negative regulation of defense response to bacterium negative regulation of reactive oxygen species metabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia uc009fzt.1 uc009fzt.2 uc009fzt.3 uc009fzt.4 
ENSMUST00000072974.2 Or8b36 ENSMUST00000072974.2 olfactory receptor family 8 subfamily B member 36 (from RefSeq NM_146419.2) ENSMUST00000072974.1 NM_146419 Olfr883 Or8b36 Q8VF64 Q8VF64_MOUSE uc009ovs.1 uc009ovs.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ovs.1 uc009ovs.2 
ENSMUST00000072976.4 Or6c204 ENSMUST00000072976.4 olfactory receptor family 6 subfamily C member 204 (from RefSeq NM_207008.2) ENSMUST00000072976.1 ENSMUST00000072976.2 ENSMUST00000072976.3 F6VS78 F6VS78_MOUSE NM_207008 Olfr772 Olfr773 Or6c204 uc007hpo.1 uc007hpo.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hpo.1 uc007hpo.2 
ENSMUST00000073029.13 Fancc ENSMUST00000073029.13 Fanconi anemia, complementation group C, transcript variant 2 (from RefSeq NM_001042673.2) ENSMUST00000073029.1 ENSMUST00000073029.10 ENSMUST00000073029.11 ENSMUST00000073029.12 ENSMUST00000073029.2 ENSMUST00000073029.3 ENSMUST00000073029.4 ENSMUST00000073029.5 ENSMUST00000073029.6 ENSMUST00000073029.7 ENSMUST00000073029.8 ENSMUST00000073029.9 Fancc NM_001042673 Q8CBR3 Q8CBR3_MOUSE uc007qxp.1 uc007qxp.2 uc007qxp.3 DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70. Nucleus nucleus cytoplasm DNA repair cellular response to DNA damage stimulus interstrand cross-link repair Fanconi anaemia nuclear complex uc007qxp.1 uc007qxp.2 uc007qxp.3 
ENSMUST00000073049.7 Ugt1a1 ENSMUST00000073049.7 UDP glucuronosyltransferase 1 family, polypeptide A1 (from RefSeq NM_201645.2) ENSMUST00000073049.1 ENSMUST00000073049.2 ENSMUST00000073049.3 ENSMUST00000073049.4 ENSMUST00000073049.5 ENSMUST00000073049.6 NM_201645 Q561M6 Q63886 Q6XL50 UD11_MOUSE Ugt1 Ugt1a1 uc007byk.1 uc007byk.2 uc007byk.3 UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (By similarity). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (By similarity). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (By similarity). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (By similarity). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (By similarity). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (By similarity). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (By similarity). Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21033; Evidence=; Reaction=17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52460, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136641; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52461; Evidence=; Reaction=2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53048, ChEBI:CHEBI:1156, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136967; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53049; Evidence=; Reaction=2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53004, ChEBI:CHEBI:15378, ChEBI:CHEBI:28744, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136931; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53005; Evidence=; Reaction=2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53072, ChEBI:CHEBI:15378, ChEBI:CHEBI:28955, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136974; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53073; Evidence=; Reaction=17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52868, ChEBI:CHEBI:15378, ChEBI:CHEBI:17160, ChEBI:CHEBI:57529, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52869; Evidence=; Reaction=16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52880, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:87620, ChEBI:CHEBI:136886; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52881; Evidence=; Reaction=losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D- glucuronide + UDP; Xref=Rhea:RHEA:63720, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:149504, ChEBI:CHEBI:149507; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63721; Evidence=; Reaction=prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D- glucuronide + UDP; Xref=Rhea:RHEA:63588, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:147403, ChEBI:CHEBI:147404; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63589; Evidence=; Reaction=SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP; Xref=Rhea:RHEA:63696, ChEBI:CHEBI:8988, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:149482; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63697; Evidence=; Homodimers. Homooligomer. Interacts with UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers. Endoplasmic reticulum membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=1; Comment=UGT1A1 is one of the isoforms produced at the UGT1A complex locus. The UGT1A complex locus produces different isoforms based on alternative use of promoters, first exons and terminal exons. ; Name=1; IsoId=Q63886-1; Sequence=Displayed; Highly expressed in liver and at lower levels in colon, kidney, stomach and intestine. By dioxin. Belongs to the UDP-glycosyltransferase family. liver development retinoic acid binding enzyme inhibitor activity steroid binding endoplasmic reticulum endoplasmic reticulum membrane integral component of plasma membrane acute-phase response response to nutrient response to organic substance response to organic cyclic compound glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups enzyme binding animal organ regeneration response to lipopolysaccharide cellular response to hormone stimulus endoplasmic reticulum chaperone complex response to drug response to starvation protein homodimerization activity negative regulation of catalytic activity intracellular membrane-bounded organelle response to ethanol protein heterodimerization activity response to steroid hormone response to glucocorticoid flavone metabolic process cellular glucuronidation flavonoid glucuronidation xenobiotic glucuronidation cytochrome complex biphenyl catabolic process cellular response to ethanol cellular response to glucocorticoid stimulus cellular response to estradiol stimulus cellular response to xenobiotic stimulus negative regulation of cellular glucuronidation uc007byk.1 uc007byk.2 uc007byk.3 
ENSMUST00000073054.5 Mppe1 ENSMUST00000073054.5 metallophosphoesterase 1, transcript variant 1 (from RefSeq NM_172630.3) ENSMUST00000073054.1 ENSMUST00000073054.2 ENSMUST00000073054.3 ENSMUST00000073054.4 MPPE1_MOUSE NM_172630 Pgap5 Q3T9I6 Q3TYP9 Q3U4F5 Q80XL7 Q8BLU5 uc008flv.1 uc008flv.2 uc008flv.3 Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI- anchor proteins (By similarity). Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; Interacts with GPI-anchor proteins. Interacts with TMED10 (By similarity). Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi- pass membrane protein Note=Also localizes to endoplasmic reticulum exit site. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80XL7-1; Sequence=Displayed; Name=2; IsoId=Q80XL7-2; Sequence=VSP_030686; Name=3; IsoId=Q80XL7-3; Sequence=VSP_030684, VSP_030685; Belongs to the metallophosphoesterase superfamily. MPPE1 family. molecular_function nucleoplasm endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cis-Golgi network GPI anchor biosynthetic process ER to Golgi vesicle-mediated transport phosphoric diester hydrolase activity membrane integral component of membrane vesicle-mediated transport hydrolase activity manganese ion binding endoplasmic reticulum-Golgi intermediate compartment membrane GPI anchor binding metal ion binding endoplasmic reticulum exit site uc008flv.1 uc008flv.2 uc008flv.3 
ENSMUST00000073080.7 Gm10053 ENSMUST00000073080.7 Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (from UniProt Q56A15) AK002732 CYCS Cycs ENSMUST00000073080.1 ENSMUST00000073080.2 ENSMUST00000073080.3 ENSMUST00000073080.4 ENSMUST00000073080.5 ENSMUST00000073080.6 Q56A15 Q56A15_MOUSE uc289rlo.1 uc289rlo.2 uc289rlo.3 Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Mitochondrion intermembrane space Binds 1 heme group per subunit. Belongs to the cytochrome c family. mitochondrion electron carrier activity heme binding electron transport chain metal ion binding oxidation-reduction process respiratory chain uc289rlo.1 uc289rlo.2 uc289rlo.3 
ENSMUST00000073089.13 Miga1 ENSMUST00000073089.13 mitoguardin 1, transcript variant 1 (from RefSeq NM_174868.4) ENSMUST00000073089.1 ENSMUST00000073089.10 ENSMUST00000073089.11 ENSMUST00000073089.12 ENSMUST00000073089.2 ENSMUST00000073089.3 ENSMUST00000073089.4 ENSMUST00000073089.5 ENSMUST00000073089.6 ENSMUST00000073089.7 ENSMUST00000073089.8 ENSMUST00000073089.9 Fam73a MIGA1_MOUSE Miga1 NM_174868 Q4QQM5 Q8BR91 Q8C3S6 Q8C8P4 uc008rte.1 uc008rte.2 uc008rte.3 uc008rte.4 uc008rte.5 Regulator of mitochondrial fusion (PubMed:26711011). Acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD (By similarity). Homodimer and heterodimer; forms heterodimers with MIGA2. Interacts with PLD6/MitoPLD. Mitochondrion outer membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q4QQM5-1; Sequence=Displayed; Name=2; IsoId=Q4QQM5-2; Sequence=VSP_024881, VSP_024882; Name=3; IsoId=Q4QQM5-3; Sequence=VSP_024880; Mitochondrial fragmentation: mitochondria become round and show loss of cristae (PubMed:26711011). Female mice show decreased quality of oocytes (PubMed:26716412). Mice lacking both Miga1 and Miga2 show strongly reduced quality of oocytes and are subfertile (PubMed:26716412). Belongs to the mitoguardin family. Sequence=BAC32059.1; Type=Frameshift; Evidence=; mitochondrion mitochondrial outer membrane integral component of plasma membrane mitochondrial fusion membrane integral component of membrane protein homodimerization activity protein heterodimerization activity uc008rte.1 uc008rte.2 uc008rte.3 uc008rte.4 uc008rte.5 
ENSMUST00000073102.2 Or52e8b ENSMUST00000073102.2 olfactory receptor family 52 subfamily E member 8B (from RefSeq NM_001011848.1) ENSMUST00000073102.1 NM_001011848 Olfr671 Olfr675 Or52e8b Q7TRP1 Q7TRP1_MOUSE uc009ixj.1 uc009ixj.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ixj.1 uc009ixj.2 
ENSMUST00000073109.12 Ctdspl ENSMUST00000073109.12 CTD small phosphatase like (from RefSeq NM_133710.3) CTDSL_MOUSE ENSMUST00000073109.1 ENSMUST00000073109.10 ENSMUST00000073109.11 ENSMUST00000073109.2 ENSMUST00000073109.3 ENSMUST00000073109.4 ENSMUST00000073109.5 ENSMUST00000073109.6 ENSMUST00000073109.7 ENSMUST00000073109.8 ENSMUST00000073109.9 NM_133710 Nif1 Nifl P58465 Q52KL5 uc009rzz.1 uc009rzz.2 uc009rzz.3 uc009rzz.4 Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per monomer. ; Monomer. Interacts with REST. Nucleus negative regulation of protein phosphorylation phosphoprotein phosphatase activity nucleus regulation of transcription from RNA polymerase II promoter protein dephosphorylation CTD phosphatase activity dephosphorylation hydrolase activity phosphatase activity metal ion binding negative regulation of G1/S transition of mitotic cell cycle uc009rzz.1 uc009rzz.2 uc009rzz.3 uc009rzz.4 
ENSMUST00000073111.3 Krtap20-20 ENSMUST00000073111.3 Interacts with hair keratins. (from UniProt D3Z714) D3Z714 D3Z714_MOUSE ENSMUST00000073111.1 ENSMUST00000073111.2 Gm10061 uc289fvy.1 uc289fvy.2 Interacts with hair keratins. molecular_function cellular_component biological_process uc289fvy.1 uc289fvy.2 
ENSMUST00000073115.5 H2ac21 ENSMUST00000073115.5 H2A clustered histone 21 (from RefSeq NM_178213.6) ENSMUST00000073115.1 ENSMUST00000073115.2 ENSMUST00000073115.3 ENSMUST00000073115.4 H2A2B_MOUSE H2ac21 Hist2h2ab NM_178213 Q64522 uc008qmh.1 uc008qmh.2 uc008qmh.3 uc008qmh.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: SRR6238556.1091733.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc008qmh.1 uc008qmh.2 uc008qmh.3 uc008qmh.4 
ENSMUST00000073120.11 Ppox ENSMUST00000073120.11 protoporphyrinogen oxidase (from RefSeq NM_008911.2) ENSMUST00000073120.1 ENSMUST00000073120.10 ENSMUST00000073120.2 ENSMUST00000073120.3 ENSMUST00000073120.4 ENSMUST00000073120.5 ENSMUST00000073120.6 ENSMUST00000073120.7 ENSMUST00000073120.8 ENSMUST00000073120.9 NM_008911 P51175 P97344 PPOX_MOUSE Q99M34 uc007dns.1 uc007dns.2 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Reaction=3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX; Xref=Rhea:RHEA:25576, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57306, ChEBI:CHEBI:57307; EC=1.3.3.4; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Inhibited by acifluorfen. Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1. Monomer. Homodimer (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side During erythroid differentiation. Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily. oxygen-dependent protoporphyrinogen oxidase activity mitochondrion mitochondrial inner membrane porphyrin-containing compound biosynthetic process protoporphyrinogen IX biosynthetic process heme biosynthetic process membrane oxidoreductase activity intrinsic component of mitochondrial inner membrane integral component of mitochondrial inner membrane mitochondrial membrane response to drug protoporphyrinogen IX metabolic process oxidation-reduction process uc007dns.1 uc007dns.2 
ENSMUST00000073122.4 Or7h8 ENSMUST00000073122.4 olfactory receptor family 7 subfamily H member 8 (from RefSeq NM_146903.2) ENSMUST00000073122.1 ENSMUST00000073122.2 ENSMUST00000073122.3 NM_146903 Olfr871 Or7h8 Q7TRF0 Q7TRF0_MOUSE uc009oie.1 uc009oie.2 uc009oie.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oie.1 uc009oie.2 uc009oie.3 
ENSMUST00000073124.9 Zfp746 ENSMUST00000073124.9 zinc finger protein 746, transcript variant 1 (from RefSeq NM_001163475.1) E9QPR1 ENSMUST00000073124.1 ENSMUST00000073124.2 ENSMUST00000073124.3 ENSMUST00000073124.4 ENSMUST00000073124.5 ENSMUST00000073124.6 ENSMUST00000073124.7 ENSMUST00000073124.8 NM_001163475 Q3U133 ZN746_MOUSE Znf746 uc009btv.1 uc009btv.2 uc009btv.3 Transcription repressor that specifically binds to the 5'- TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. Interacts (via C2H2-type zinc fingers) with PRKN (PubMed:21376232). Interacts with TRIM28 (By similarity). Q3U133; Q9WVS6: Prkn; NbExp=2; IntAct=EBI-3862590, EBI-973635; Cytoplasm Nucleus Note=Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes. Widely expressed. In brain, it is heterogeneously distributed throughout the brain and localizes to neurons, including substantia nigra pars compacta dopamine-containing neurons. Weakly expressed in cerebellum and midbrain (at protein level). Ubiquitinated by PRKN. 'Lys-48'-linked polyubiquitination by PRKN leads to degradation by the proteasome and may play a key role in regulation of neuron death (By similarity). Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAE33667.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated ubiquitin protein ligase binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of neuron death uc009btv.1 uc009btv.2 uc009btv.3 
ENSMUST00000073127.14 Ncapd3 ENSMUST00000073127.14 non-SMC condensin II complex, subunit D3, transcript variant 1 (from RefSeq NM_178113.4) ENSMUST00000073127.1 ENSMUST00000073127.10 ENSMUST00000073127.11 ENSMUST00000073127.12 ENSMUST00000073127.13 ENSMUST00000073127.2 ENSMUST00000073127.3 ENSMUST00000073127.4 ENSMUST00000073127.5 ENSMUST00000073127.6 ENSMUST00000073127.7 ENSMUST00000073127.8 ENSMUST00000073127.9 K4DI67 K4DI67_MOUSE NM_178113 Ncapd3 uc009oqh.1 uc009oqh.2 uc009oqh.3 uc009oqh.4 Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Component of the condensin-2 complex. Nucleus condensed chromosome, centromeric region nuclear condensin complex chromatin binding nucleus nucleoplasm cell cycle mitotic chromosome condensation meiotic chromosome condensation chromosome condensation nuclear pericentric heterochromatin methylated histone binding cell division chromosome separation uc009oqh.1 uc009oqh.2 uc009oqh.3 uc009oqh.4 
ENSMUST00000073139.14 Ndrg4 ENSMUST00000073139.14 N-myc downstream regulated gene 4, transcript variant 11 (from RefSeq NM_001372431.1) ENSMUST00000073139.1 ENSMUST00000073139.10 ENSMUST00000073139.11 ENSMUST00000073139.12 ENSMUST00000073139.13 ENSMUST00000073139.2 ENSMUST00000073139.3 ENSMUST00000073139.4 ENSMUST00000073139.5 ENSMUST00000073139.6 ENSMUST00000073139.7 ENSMUST00000073139.8 ENSMUST00000073139.9 Kiaa1180 NDRG4_MOUSE NM_001372431 Ndr4 Q6ZPW3 Q8BTG7 Q923D7 uc009myu.1 uc009myu.2 uc009myu.3 Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BTG7-1; Sequence=Displayed; Name=2; IsoId=Q8BTG7-2; Sequence=VSP_022959; Name=3; IsoId=Q8BTG7-3; Sequence=VSP_022958; Predominantly expressed in the brain (at protein level). Detected in neurons of various parts of brain, including the olfactory bulb, olfactory tuberculum, cerebral cortex, striatum, hippocampus, dentate gyrus, thalamus, hypothalamus, mesencephalon, cerebellum, pons and medulla oblongata. Mutant mice have impaired spatial learning and memory but normal motor function. Belongs to the NDRG family. Sequence=BAC98115.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding cytoplasm mitochondrion endoplasmic reticulum membrane cytosol signal transduction brain development visual learning negative regulation of platelet-derived growth factor receptor signaling pathway positive regulation of neuron projection development negative regulation of smooth muscle cell migration basolateral plasma membrane cell projection membrane vesicle docking negative regulation of smooth muscle cell proliferation cell migration involved in heart development positive regulation of ERK1 and ERK2 cascade regulation of endocytic recycling uc009myu.1 uc009myu.2 uc009myu.3 
ENSMUST00000073143.7 Cimip3 ENSMUST00000073143.7 ciliary microtubule inner protein 3, transcript variant 3 (from RefSeq NM_001347584.1) 1700001C19Rik Cimip3 E9Q6U5 E9Q6U5_MOUSE ENSMUST00000073143.1 ENSMUST00000073143.2 ENSMUST00000073143.3 ENSMUST00000073143.4 ENSMUST00000073143.5 ENSMUST00000073143.6 NM_001347584 uc057kyb.1 uc057kyb.2 uc057kyb.3 molecular_function cellular_component biological_process uc057kyb.1 uc057kyb.2 uc057kyb.3 
ENSMUST00000073149.7 Slc9a5 ENSMUST00000073149.7 solute carrier family 9 (sodium/hydrogen exchanger), member 5, transcript variant 6 (from RefSeq NR_175837.1) B2RXE2 ENSMUST00000073149.1 ENSMUST00000073149.2 ENSMUST00000073149.3 ENSMUST00000073149.4 ENSMUST00000073149.5 ENSMUST00000073149.6 NR_175837 Nhe5 SL9A5_MOUSE uc009ncu.1 uc009ncu.2 uc009ncu.3 Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Responsible for regulating intracellular pH homeostasis, in particular in neural tissues. Acts as a negative regulator of dendritic spine growth. Plays a role in postsynaptic remodeling and signaling. Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking. Reaction=H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out); Xref=Rhea:RHEA:29419, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29421; Evidence=; Interacts with CHP1 and CHP2 (By similarity). Interacts with ARRB2; facilitates the endocytosis of SLC9A5 from the plasma membrane (By similarity). Interacts with RACK1; this interaction positively regulates SLC9A5 activity and promote SLC9A5 localization to focal adhesions (By similarity). Interacts with SCAMP2; this interaction regulates SLC9A5 cell-surface targeting and SLC9A5 activity (By similarity). Cell membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Cell projection, dendritic spine membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein. Cell junction, focal adhesion Note=Cycles between recycling endosome and plasma membrane in response to diverse stimuli. Its internalization is clathrin- and beta-arrestin dependent and its plasma membrane insertion from the recycling endosomes requires phosphoinositide 3- kinase (PIK3CA) and SCAMP2. Highest expression level is detected in brain (PubMed:28981195). Expressed in hippocampal neurons (at protein level) (PubMed:21551074). Phosphorylated by PRKAA2; promotes its accumulation at the cell surface. Phosphorylated by CSNK2A1 in a manner favoring its beta- arrestin binding and endocytosis. Deficient mice are born at normal Mendelian ratios without gross abnormalities in postnatal development. However, deficient mice display significant enhancement of learning and memory accompanied by an increase in the number of hippocampal excitatory synapses in the hippocampus. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. plasma membrane ion transport cation transport sodium ion transport regulation of pH antiporter activity solute:proton antiporter activity sodium:proton antiporter activity potassium:proton antiporter activity membrane integral component of membrane regulation of intracellular pH transmembrane transport potassium ion transmembrane transport anion transmembrane transport sodium ion import across plasma membrane hydrogen ion transmembrane transport uc009ncu.1 uc009ncu.2 uc009ncu.3 
ENSMUST00000073150.6 Peli2 ENSMUST00000073150.6 pellino 2, transcript variant 1 (from RefSeq NM_033602.3) E9QPQ6 E9QPQ6_MOUSE ENSMUST00000073150.1 ENSMUST00000073150.2 ENSMUST00000073150.3 ENSMUST00000073150.4 ENSMUST00000073150.5 NM_033602 Peli2 uc007tjh.1 uc007tjh.2 uc007tjh.3 E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Belongs to the pellino family. protein polyubiquitination positive regulation of protein phosphorylation Toll signaling pathway regulation of Toll signaling pathway protein ubiquitination transferase activity positive regulation of MAPK cascade ubiquitin protein ligase activity uc007tjh.1 uc007tjh.2 uc007tjh.3 
ENSMUST00000073151.13 Nlrp9b ENSMUST00000073151.13 NLR family, pyrin domain containing 9B (from RefSeq NM_194058.2) ENSMUST00000073151.1 ENSMUST00000073151.10 ENSMUST00000073151.11 ENSMUST00000073151.12 ENSMUST00000073151.2 ENSMUST00000073151.3 ENSMUST00000073151.4 ENSMUST00000073151.5 ENSMUST00000073151.6 ENSMUST00000073151.7 ENSMUST00000073151.8 ENSMUST00000073151.9 NLR9B_MOUSE NM_194058 Nalp9 Nalp9b Q66X22 Q6UTW9 uc009fnt.1 uc009fnt.2 uc009fnt.3 As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments. Sensor component of NLRP9 inflammasomes. Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens, such as rotavirus, but not encephalomyocarditis virus (EMCV), and play critical roles in innate immunity and inflammation. The core of NLRP9 inflammasomes consists of a signal sensor component (NLRP9), an adapter (ASC/PYCARD), which recruits an effector pro- inflammatory caspase (CASP1). Within the complex, NLRP9 and PYCARD interact via their respective DAPIN/pyrin domains. This interaction initiates speck formation (nucleation) which greatly enhances further addition of soluble PYCARD molecules to the speck in a prion-like polymerization process. Clustered PYCARD nucleates the formation of CASP1 filaments through the interaction of their respective CARD domains, acting as a platform for CASP1 polymerization. CASP1 filament formation increases local enzyme concentration, resulting in trans- autocleavage and activation. Active CASP1 then processes IL1B and IL18 precursors, leading to the release of mature cytokines in the extracellular milieu and inflammatory response. Interacts with DHX9 upon rotavirus infection; this interaction may trigger inflammasome activation and inflammatory response. Cytoplasm Inflammasome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q66X22-1; Sequence=Displayed; Name=2; IsoId=Q66X22-2; Sequence=VSP_025024, VSP_025025, VSP_025026; Predominantly expressed in the intestine, including proximal and distal colon, cecum, ileum, jejunum and duodenum (at protein level) (PubMed:26411641, PubMed:28636595). In the ileum, expressed in epithelial cells (PubMed:28636595). Also expressed in oocytes at all follicular stages and in preimplantation embryos (at protein level) (PubMed:15317747, PubMed:26411641). Although expression decreases in preimplantation embryos, it is still detectable in blastocyts (PubMed:26411641). Down-regulated in preimplantation embryos, with decreased levels observed at the 4-cell stages. Still detectable in blastocysts (at protein level) (PubMed:15317747). Expression in oocytes decline with age. It is much higher at 10 weeks of age rather than at 40 (at protein level) (PubMed:26411641). In ileum epithelial cells, up- regulated in the first 12 hours following rotavirus infection. Levels drastically decrease 36 hours post infection (at protein level) (PubMed:28636595). No visible phenotype. Mutant mice exhibit normal gut homeostasis and microbiota composition. Following rotavirus infection, mutant animals have higher viral loads in the small intestine, increased fecal shedding of viral antigens, and more frequent incidences of diarrhea compared to wild-type littermates. Mice with a conditional knockout in ileum intestinal epithelial cells are also more susceptible to rotavirus infection compared to control animals. nucleotide binding immune system process molecular_function ATP binding cytoplasm inflammatory response positive regulation of interleukin-18 production innate immune response defense response to virus inflammasome complex pyroptosis uc009fnt.1 uc009fnt.2 uc009fnt.3 
ENSMUST00000073152.13 Fastkd1 ENSMUST00000073152.13 FAST kinase domains 1 (from RefSeq NM_177244.3) A2AR00 B0R0D3 ENSMUST00000073152.1 ENSMUST00000073152.10 ENSMUST00000073152.11 ENSMUST00000073152.12 ENSMUST00000073152.2 ENSMUST00000073152.3 ENSMUST00000073152.4 ENSMUST00000073152.5 ENSMUST00000073152.6 ENSMUST00000073152.7 ENSMUST00000073152.8 ENSMUST00000073152.9 FAKD1_MOUSE Kiaa1800 NM_177244 Q5DTU7 Q6DI86 Q6IS39 Q8BSV8 Q8C429 Q8R1N6 uc008jyh.1 uc008jyh.2 uc008jyh.3 uc008jyh.4 Involved in the down-regulation of mitochondrial MT-ND3 mRNA levels which leads to decreased respiratory complex I abundance and activity. Mitochondrion Note=Preferentially localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6DI86-1; Sequence=Displayed; Name=2; IsoId=Q6DI86-2; Sequence=VSP_024620; Name=3; IsoId=Q6DI86-3; Sequence=VSP_024621; Name=4; IsoId=Q6DI86-4; Sequence=VSP_024618, VSP_024619; Expression detected in spleen, testis, colon, heart, smooth muscle, kidney, brain, lung, liver, brown and white adipose tissue with highest expression in heart and brown adipose tissue. The RAP domain is essential to regulate MT-ND3 mRNA levels. Belongs to the FAST kinase family. mitochondrial RNA metabolic process protein kinase activity mitochondrion protein phosphorylation regulation of mitochondrial mRNA stability uc008jyh.1 uc008jyh.2 uc008jyh.3 uc008jyh.4 
ENSMUST00000073157.15 Zfp65 ENSMUST00000073157.15 zinc finger protein 65, transcript variant 1 (from RefSeq NM_145622.3) ENSMUST00000073157.1 ENSMUST00000073157.10 ENSMUST00000073157.11 ENSMUST00000073157.12 ENSMUST00000073157.13 ENSMUST00000073157.14 ENSMUST00000073157.2 ENSMUST00000073157.3 ENSMUST00000073157.4 ENSMUST00000073157.5 ENSMUST00000073157.6 ENSMUST00000073157.7 ENSMUST00000073157.8 ENSMUST00000073157.9 NM_145622 Q91W94 Q91W94_MOUSE Zfp65 Zfp71-rs1 uc007rbk.1 uc007rbk.2 uc007rbk.3 uc007rbk.4 May be involved in transcriptional regulation. nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc007rbk.1 uc007rbk.2 uc007rbk.3 uc007rbk.4 
ENSMUST00000073179.6 Ppp1r14bl ENSMUST00000073179.6 protein phosphatase 1, regulatory inhibitor subunit 14B like (from RefSeq NM_025746.2) 4933415F23Rik ENSMUST00000073179.1 ENSMUST00000073179.2 ENSMUST00000073179.3 ENSMUST00000073179.4 ENSMUST00000073179.5 NM_025746 Ppp1r14bl Q14BX6 Q14BX6_MOUSE uc007alz.1 uc007alz.2 uc007alz.3 Inhibitor of PPP1CA. Membrane ; Peripheral membrane protein Belongs to the PP1 inhibitor family. protein serine/threonine phosphatase inhibitor activity cellular_component cytoplasm negative regulation of phosphoprotein phosphatase activity regulation of phosphorylation innate immune response uc007alz.1 uc007alz.2 uc007alz.3 
ENSMUST00000073192.14 Erlec1 ENSMUST00000073192.14 endoplasmic reticulum lectin 1 (from RefSeq NM_025745.3) ENSMUST00000073192.1 ENSMUST00000073192.10 ENSMUST00000073192.11 ENSMUST00000073192.12 ENSMUST00000073192.13 ENSMUST00000073192.2 ENSMUST00000073192.3 ENSMUST00000073192.4 ENSMUST00000073192.5 ENSMUST00000073192.6 ENSMUST00000073192.7 ENSMUST00000073192.8 ENSMUST00000073192.9 ERLEC_MOUSE NM_025745 Q3UZF3 Q8BVN6 Q8VEH8 uc007iic.1 uc007iic.2 uc007iic.3 Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non- glycosylated proteins and glycoproteins (By similarity). May form a complex with OS9, HSPA5, SYVN1, and SEL1L with which it interacts directly. Interacts (via PRKCSH 2 domain) with KREMEN2 (when glycosylated). Interacts with HSPA5 (By similarity). Endoplasmic reticulum lumen N-glycosylated. protein binding endoplasmic reticulum endoplasmic reticulum lumen ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol unfolded protein binding negative regulation of retrograde protein transport, ER to cytosol uc007iic.1 uc007iic.2 uc007iic.3 
ENSMUST00000073208.6 H2-Q1 ENSMUST00000073208.6 histocompatibility 2, Q region locus 1, transcript variant 1 (from RefSeq NM_010390.4) ENSMUST00000073208.1 ENSMUST00000073208.2 ENSMUST00000073208.3 ENSMUST00000073208.4 ENSMUST00000073208.5 H2-Q1 NM_010390 O19441 O19441_MOUSE uc008chj.1 uc008chj.2 uc008chj.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response external side of plasma membrane cell surface membrane integral component of membrane antigen processing and presentation beta-2-microglobulin binding peptide binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex TAP binding protein heterodimerization activity endoplasmic reticulum exit site uc008chj.1 uc008chj.2 uc008chj.3 
ENSMUST00000073228.12 Slc52a3 ENSMUST00000073228.12 solute carrier protein family 52, member 3, transcript variant 1 (from RefSeq NM_027172.3) A2AQU3 ENSMUST00000073228.1 ENSMUST00000073228.10 ENSMUST00000073228.11 ENSMUST00000073228.2 ENSMUST00000073228.3 ENSMUST00000073228.4 ENSMUST00000073228.5 ENSMUST00000073228.6 ENSMUST00000073228.7 ENSMUST00000073228.8 ENSMUST00000073228.9 NM_027172 Q3TDJ6 Q3U328 Q8CE36 Q91WB9 Q9D6X5 RFVT3 Rft2 S52A3_MOUSE uc008neu.1 uc008neu.2 uc008neu.3 uc008neu.4 Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Reaction=riboflavin(in) = riboflavin(out); Xref=Rhea:RHEA:35015, ChEBI:CHEBI:57986; Evidence=; Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D6X5-1; Sequence=Displayed; Name=2; IsoId=Q9D6X5-2; Sequence=VSP_003816, VSP_003817; Within the small intestine, it is particularly expressed in the jujenum and the ileum. Almost negligible expression in the stomach, duodenum, and large intestine. Belongs to the riboflavin transporter family. protein binding nucleus cytoplasm plasma membrane integral component of plasma membrane sensory perception of sound membrane integral component of membrane riboflavin transporter activity riboflavin transport cellular response to heat uc008neu.1 uc008neu.2 uc008neu.3 uc008neu.4 
ENSMUST00000073234.9 Atxn7l3 ENSMUST00000073234.9 ataxin 7-like 3, transcript variant 6 (from RefSeq NM_001403852.1) A2AWT2 A2AWT3 A2AWT4 AT7L3_MOUSE ENSMUST00000073234.1 ENSMUST00000073234.2 ENSMUST00000073234.3 ENSMUST00000073234.4 ENSMUST00000073234.5 ENSMUST00000073234.6 ENSMUST00000073234.7 ENSMUST00000073234.8 NM_001403852 Q8C1T7 uc007lrh.1 uc007lrh.2 uc007lrh.3 Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AWT3-1; Sequence=Displayed; Name=2; IsoId=A2AWT3-2; Sequence=VSP_036728; The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module. The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module. Belongs to the SGF11 family. Sequence=CAM25078.1; Type=Erroneous gene model prediction; Evidence=; SAGA complex transcription coactivator activity nucleus chromatin organization zinc ion binding histone monoubiquitination histone deubiquitination ligand-dependent nuclear receptor transcription coactivator activity positive regulation of transcription, DNA-templated metal ion binding DUBm complex uc007lrh.1 uc007lrh.2 uc007lrh.3 
ENSMUST00000073248.2 Or8g18 ENSMUST00000073248.2 olfactory receptor family 8 subfamily G member 18 (from RefSeq NM_207665.1) ENSMUST00000073248.1 NM_207665 O8G18_MOUSE Olfr144 Olfr1537 Olfr7 Or8g18 P34983 Q7TRB4 Q9EQA1 uc009oxt.1 uc009oxt.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oxt.1 uc009oxt.2 
ENSMUST00000073251.8 Ccdc177 ENSMUST00000073251.8 coiled-coil domain containing 177 (from RefSeq NM_001008423.2) CC177_MOUSE ENSMUST00000073251.1 ENSMUST00000073251.2 ENSMUST00000073251.3 ENSMUST00000073251.4 ENSMUST00000073251.5 ENSMUST00000073251.6 ENSMUST00000073251.7 Gm1568 NM_001008423 Q3UHB8 Q6NXJ5 uc007obh.1 uc007obh.2 uc007obh.3 uc007obh.4 molecular_function cellular_component biological_process uc007obh.1 uc007obh.2 uc007obh.3 uc007obh.4 
ENSMUST00000073252.9 Chrnd ENSMUST00000073252.9 cholinergic receptor, nicotinic, delta polypeptide (from RefSeq NM_021600.3) Chrnd ENSMUST00000073252.1 ENSMUST00000073252.2 ENSMUST00000073252.3 ENSMUST00000073252.4 ENSMUST00000073252.5 ENSMUST00000073252.6 ENSMUST00000073252.7 ENSMUST00000073252.8 NM_021600 Q80VZ5 Q80VZ5_MOUSE uc007bwf.1 uc007bwf.2 uc007bwf.3 uc007bwf.4 This gene encodes the delta subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The delta subunit together with the alpha subunit forms the ligand-binding site. [provided by RefSeq, Nov 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052153.1, BC141376.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. Lacks conserved residue(s) required for the propagation of feature annotation. skeletal muscle contraction transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity nucleoplasm cytosol plasma membrane acetylcholine-gated channel complex ion transport cation transport ligand-gated ion channel activity membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction neuromuscular junction ion transmembrane transport synapse postsynaptic membrane skeletal muscle tissue growth musculoskeletal movement regulation of postsynaptic membrane potential excitatory postsynaptic potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc007bwf.1 uc007bwf.2 uc007bwf.3 uc007bwf.4 
ENSMUST00000073261.3 H2ac10 ENSMUST00000073261.3 H2A clustered histone 10 (from RefSeq NM_175661.3) ENSMUST00000073261.1 ENSMUST00000073261.2 H2A1F_MOUSE Hist1h2af NM_175661 Q08AU5 Q8CGP5 uc007ptw.1 uc007ptw.2 uc007ptw.3 uc007ptw.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC125011.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007ptw.1 uc007ptw.2 uc007ptw.3 uc007ptw.4 
ENSMUST00000073277.12 Ccdc154 ENSMUST00000073277.12 Ccdc154 (from geneSymbol) A0A570Y9P0 A0A570Y9P0_MOUSE AK133084 Ccdc154 ENSMUST00000073277.1 ENSMUST00000073277.10 ENSMUST00000073277.11 ENSMUST00000073277.2 ENSMUST00000073277.3 ENSMUST00000073277.4 ENSMUST00000073277.5 ENSMUST00000073277.6 ENSMUST00000073277.7 ENSMUST00000073277.8 ENSMUST00000073277.9 uc289ihk.1 uc289ihk.2 uc289ihk.1 uc289ihk.2 
ENSMUST00000073295.3 Gsdma3 ENSMUST00000073295.3 gasdermin A3 (from RefSeq NM_001007461.2) A2A4X5 ENSMUST00000073295.1 ENSMUST00000073295.2 GSDA3_MOUSE Gsdm3 Gsdma3 NM_001007461 Q5Y4Y6 uc007lgs.1 uc007lgs.2 [Gasdermin-A3]: Precursor of a pore-forming protein involved in the transition from catagen to telogen at the end of hair follicle morphogenesis (PubMed:15475261, PubMed:26375003, PubMed:27281216). This form constitutes the precursor of the pore: upon cleavage, the released N-terminal moiety (Gasdermin-A3, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:27281216, PubMed:35545613). This form acts as a sensor of infection: activation is triggered by cleavage by some bacterial effector protein, which releases the N-terminal moiety (Gasdermin-A3, N-terminal) (By similarity). [Gasdermin-A3, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:26375003, PubMed:27281216, PubMed:35545613). Released upon cleavage by some bacterial effector protein, and binds to membrane inner leaflet lipids (By similarity). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukin-1 (IL1B and IL18) and triggering pyroptosis (PubMed:27281216, PubMed:33883744, PubMed:35545613). Binds to membrane inner leaflet lipids, including bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to monophosphorylated phosphatidylinositols (PubMed:27281216). Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216, PubMed:29695864). Plays a role in the transition from catagen to telogen at the end of hair follicle morphogenesis, possibly by regulating hair follicle stem cell niche maintenance (PubMed:15475261, PubMed:15737203, PubMed:17572385, PubMed:22155111, PubMed:32302611). Also required for mammary gland development (PubMed:28168650). [Gasdermin-A3]: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C- terminal domains mediate autoinhibition in the absence of activation signal (PubMed:25825937, PubMed:26100518, PubMed:26375003). The intrinsic pyroptosis-inducing activity is carried by the released N- terminal moiety (Gasdermin-A3, N-terminal) (PubMed:26100518, PubMed:26375003). [Gasdermin-A3, N-terminal]: Homooligomer; homooligomeric ring- shaped pore complex containing 18-36 subunits when inserted in the membrane. [Gasdermin-A3]: Cytoplasm, cytosol [Gasdermin-A3, N-terminal]: Cell membrane ; Multi-pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Highest levels in skin with weak expression in placenta and testis. Not detected in the gastrointestinal tract. In skin, expressed in postnatal hair follicles and epidermis as well as sebaceous gland basal cells. Not detected at postnatal day 1. Expressed on subsequent postnatal days up to day 20 and throughout adulthood. Intramolecular interactions between N- and C-terminal domains are important for autoinhibition in the absence of activation signal (PubMed:26375003). The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain (PubMed:26375003). [Gasdermin-A3, N-terminal]: Forms a ring-shaped pore complex containing 27-28 subunits that inserts into the membrane (PubMed:33883744). The pore conduit is predominantly negatively charged, facilitating the release of mature interleukin-1 (IL1B and IL18). In contrast interleukin-1 precursors are not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). Cleavage relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-A3, N-terminal) that initiates pyroptosis (By similarity). In contrast to Gsdma, not cleaved by bacterial effector protein SpeB (PubMed:35110732). No visible phenotype (PubMed:25825937). A number of gain-of-function mutations, such as alopecia and excoriation (AE), bareskin (Bsk), defolliculated (Dfl), finnegan (Fgn) reduced coat 2 (Rco2), Rex-denuded (Re-den) and recombination induced mutation 3 (Rim3), have been identified: they cause progressive hair loss (alopecia) accompanied with hyperkeratosis and chronic skin inflammation (PubMed:15475261, PubMed:15737203, PubMed:17572385, PubMed:22155111). Gain-of-function mutations cause bulge stem cell depletion, leading to skin inflammation and alopecia (PubMed:22155111). Mice lacking Gsdma, Gsdma2 and Gsdma3 are highly susceptible to subcutaneous group A Streptococcus (GAS) infection in an animal model (PubMed:35545676). Pyroptosis-induced inflammation mediated by Gsdma3 triggers robust anti-tumor immunity and may be used in therapies to suppress tumor growth (PubMed:32188939). Use of a nanoparticle-mediated delivery system that selectively directs release of N-terminal moiety (Gasdermin-A3, N-terminal) into tumor cells, triggers pyroptosis and robust anti-tumor immunity (PubMed:32188939). Pyroptosis of less than 15% of tumor cells is sufficient to clear the entire tumor in a mammary tumor graft (PubMed:32188939). Belongs to the gasdermin family. Sequence=CAM24379.1; Type=Erroneous gene model prediction; Evidence=; phosphatidylserine binding hair follicle development sebaceous gland cell differentiation phosphatidylinositol-4,5-bisphosphate binding nucleus cytoplasm cytosol plasma membrane multicellular organism development programmed cell death membrane hair follicle morphogenesis somatic stem cell population maintenance avascular cornea development in camera-type eye hair cycle positive regulation of apoptotic process skin development negative regulation of anagen pyroptosis phosphatidylinositol-4-phosphate binding negative regulation of canonical Wnt signaling pathway positive regulation of extrinsic apoptotic signaling pathway uc007lgs.1 uc007lgs.2 
ENSMUST00000073312.7 Zfp760 ENSMUST00000073312.7 zinc finger protein 760, transcript variant 5 (from RefSeq NM_001410566.1) E9QAF5 E9QAF5_MOUSE ENSMUST00000073312.1 ENSMUST00000073312.2 ENSMUST00000073312.3 ENSMUST00000073312.4 ENSMUST00000073312.5 ENSMUST00000073312.6 NM_001410566 Zfp760 uc008arf.1 uc008arf.2 uc008arf.3 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc008arf.1 uc008arf.2 uc008arf.3 
ENSMUST00000073316.13 Foxm1 ENSMUST00000073316.13 forkhead box M1 (from RefSeq NM_008021.4) ENSMUST00000073316.1 ENSMUST00000073316.10 ENSMUST00000073316.11 ENSMUST00000073316.12 ENSMUST00000073316.2 ENSMUST00000073316.3 ENSMUST00000073316.4 ENSMUST00000073316.5 ENSMUST00000073316.6 ENSMUST00000073316.7 ENSMUST00000073316.8 ENSMUST00000073316.9 Foxm1 NM_008021 Q6P1H7 Q6P1H7_MOUSE uc009edl.1 uc009edl.2 uc009edl.3 Nucleus G2/M transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator positive regulation of cell proliferation protein kinase binding negative regulation of stress-activated MAPK cascade sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of Ras protein signal transduction regulation of cell cycle arrest negative regulation of cell aging regulation of reactive oxygen species metabolic process positive regulation of double-strand break repair uc009edl.1 uc009edl.2 uc009edl.3 
ENSMUST00000073339.7 Pgrmc1 ENSMUST00000073339.7 progesterone receptor membrane component 1 (from RefSeq NM_016783.4) ENSMUST00000073339.1 ENSMUST00000073339.2 ENSMUST00000073339.3 ENSMUST00000073339.4 ENSMUST00000073339.5 ENSMUST00000073339.6 NM_016783 Pgrmc1 Q3TXU8 Q3TXU8_MOUSE uc009sxo.1 uc009sxo.2 uc009sxo.3 uc009sxo.4 Endoplasmic reticulum membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein Microsome membrane ; Single-pass membrane protein Mitochondrion outer membrane ; Single-pass membrane protein ; Extracellular side Secreted Belongs to the cytochrome b5 family. MAPR subfamily. membrane integral component of membrane uc009sxo.1 uc009sxo.2 uc009sxo.3 uc009sxo.4 
ENSMUST00000073350.13 Ctse ENSMUST00000073350.13 cathepsin E (from RefSeq NM_007799.3) CATE_MOUSE ENSMUST00000073350.1 ENSMUST00000073350.10 ENSMUST00000073350.11 ENSMUST00000073350.12 ENSMUST00000073350.2 ENSMUST00000073350.3 ENSMUST00000073350.4 ENSMUST00000073350.5 ENSMUST00000073350.6 ENSMUST00000073350.7 ENSMUST00000073350.8 ENSMUST00000073350.9 NM_007799 O35647 P70269 Q3UKT5 Q4FK00 uc007cnn.1 uc007cnn.2 uc007cnn.3 uc007cnn.4 This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005432.1, AK145875.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. Reaction=Similar to cathepsin D, but slightly broader specificity.; EC=3.4.23.34; Evidence=; Homodimer; disulfide-linked. Endosome Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome. Expressed abundantly in the stomach, club cells and alveolar macrophages of the lung, brain microglia, spleen and activated B-lymphocytes. Not expressed in resting B-lymphocytes. Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. Belongs to the peptidase A1 family. aspartic-type endopeptidase activity endosome proteolysis peptidase activity protein autoprocessing hydrolase activity antigen processing and presentation of exogenous peptide antigen via MHC class II protein catabolic process protein homodimerization activity uc007cnn.1 uc007cnn.2 uc007cnn.3 uc007cnn.4 
ENSMUST00000073363.2 Amtn ENSMUST00000073363.2 amelotin (from RefSeq NM_027793.1) AMTN_MOUSE ENSMUST00000073363.1 NM_027793 Q9D3J8 uc008xzq.1 uc008xzq.2 Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. Secreted Specifically expressed in maturation-stage ameloblasts. Expression increases greatly with the transition from secretory to maturation-stage ameloblasts, is maintained during the maturation stage and gradually declines towards the zone of reduced ameloblasts. Phosphorylated by FAM20C in vitro. O-glycosylated. Belongs to the amelotin family. molecular_function extracellular region basement membrane cell-cell junction cell adhesion extracellular matrix biomineral tissue development odontogenesis of dentin-containing tooth positive regulation of biomineral tissue development positive regulation of enamel mineralization uc008xzq.1 uc008xzq.2 
ENSMUST00000073364.6 Fam120c ENSMUST00000073364.6 family with sequence similarity 120, member C (from RefSeq NM_198105.2) ENSMUST00000073364.1 ENSMUST00000073364.2 ENSMUST00000073364.3 ENSMUST00000073364.4 ENSMUST00000073364.5 F120C_MOUSE NM_198105 ORF34 Q3U0F6 Q8C3F2 uc009upc.1 uc009upc.2 uc009upc.3 uc009upc.4 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C3F2-1; Sequence=Displayed; Name=2; IsoId=Q8C3F2-2; Sequence=VSP_010521, VSP_010522; Name=3; IsoId=Q8C3F2-3; Sequence=VSP_010523, VSP_010524; Belongs to the constitutive coactivator of PPAR-gamma family. Sequence=BAC39601.1; Type=Erroneous initiation; Evidence=; nucleus biological_process uc009upc.1 uc009upc.2 uc009upc.3 uc009upc.4 
ENSMUST00000073387.5 Epha1 ENSMUST00000073387.5 Eph receptor A1 (from RefSeq NM_023580.4) ENSMUST00000073387.1 ENSMUST00000073387.2 ENSMUST00000073387.3 ENSMUST00000073387.4 EPHA1_MOUSE Esk NM_023580 Q60750 Q8CED9 Q9ESJ2 uc009brc.1 uc009brc.2 Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2/FAK1 (By similarity). Cell membrane ; Single-pass type I membrane protein Preferentially expressed in epithelial cells including skin, kidney, liver and thymus (PubMed:11519828, PubMed:18802966). Expressed in myogenic progenitor cells (PubMed:27446912). In myogenic progenitor cells, expressed during the acquisition of muscle stem cell properties, from 18.5 dpc to adulthood. Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1 (By similarity). Ubiquitinated. Mice display a partially-penetrant uterovaginal and tail development defects. The uterovaginal defect is due to a defect in apoptosis during development. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. nucleotide binding angiogenesis positive regulation of cell-matrix adhesion protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity transmembrane-ephrin receptor activity ATP binding plasma membrane integral component of plasma membrane protein phosphorylation negative regulation of protein kinase activity cell adhesion cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway axon guidance positive regulation of cell proliferation membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation protein kinase binding positive regulation of cell migration negative regulation of cell migration substrate adhesion-dependent cell spreading neuron projection regulation of GTPase activity dendritic spine receptor complex positive regulation of angiogenesis protein autophosphorylation ephrin receptor signaling pathway positive regulation of stress fiber assembly activation of GTPase activity uc009brc.1 uc009brc.2 
ENSMUST00000073388.13 Afmid ENSMUST00000073388.13 arylformamidase, transcript variant 3 (from RefSeq NM_027827.3) B1AQK9 ENSMUST00000073388.1 ENSMUST00000073388.10 ENSMUST00000073388.11 ENSMUST00000073388.12 ENSMUST00000073388.2 ENSMUST00000073388.3 ENSMUST00000073388.4 ENSMUST00000073388.5 ENSMUST00000073388.6 ENSMUST00000073388.7 ENSMUST00000073388.8 ENSMUST00000073388.9 KFA_MOUSE NM_027827 Q80XP3 Q8K4H1 Q8R1K6 uc007mob.1 uc007mob.2 uc007mob.3 uc007mob.4 Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. Reaction=H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine; Xref=Rhea:RHEA:13009, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:57959, ChEBI:CHEBI:58629; EC=3.5.1.9; Evidence=; Kinetic parameters: KM=0.18 mM for N-formyl-L-kynurenine ; Vmax=42 umol/min/mg enzyme ; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. Homodimer. Cytoplasm, cytosol cleus Note=Predominantly cytosolic. Some fraction is nuclear. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K4H1-1; Sequence=Displayed; Name=2; IsoId=Q8K4H1-2; Sequence=VSP_020237; Highly expressed in liver. Expressed in kidney. Weakly or not expressed in other tissues. Down-regulated upon IL2-mediated activation. Transcriptional activation correlates with reduced histone acetylation. The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage. The N-terminus is blocked. Mice display sclerosis of kidney glomeruli, possibly due to failures in the elimination of toxic metabolites. The Afmid gene shares a bidirectional promoter region with Tk1 gene. Belongs to the kynurenine formamidase family. Sequence=AAH24452.1; Type=Erroneous initiation; Evidence=; arylformamidase activity nucleus cytoplasm cytosol tryptophan catabolic process catabolic process NAD biosynthetic process hydrolase activity tryptophan catabolic process to kynurenine 'de novo' NAD biosynthetic process from tryptophan uc007mob.1 uc007mob.2 uc007mob.3 uc007mob.4 
ENSMUST00000073391.5 Cyp26c1 ENSMUST00000073391.5 cytochrome P450, family 26, subfamily c, polypeptide 1 (from RefSeq NM_001105201.1) B2RXA7 CP26C_MOUSE Cyp26c1 ENSMUST00000073391.1 ENSMUST00000073391.2 ENSMUST00000073391.3 ENSMUST00000073391.4 NM_001105201 uc012ble.1 uc012ble.2 uc012ble.3 A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (Probable) (PubMed:15911617). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13- cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the oxidation of atRA primarily at C-4 (Probable). Oxidation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination, thereby contributes to the regulation of atRA homeostasis and signaling. Able to metabolize other RAs such as 9-cis with high efficiency (By similarity). Can oxidize all-trans-13,14- dihydroretinoate (DRA) to metabolites which could include all-trans-4- oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all- trans-18-hydroxy-DRA (Probable). Shares sequence similarity with other CYP26 family members, but has higher affinity to 9-cis-RA and is much less sensitive to the inhibitory effects of ketoconazole (By similarity). In cooperation with Cyp26a1, contributes to the CNS patterning and the development of regions of higher visual acuity (PubMed:15531370, PubMed:17067568). Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence=; Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51984, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134178; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51985; Evidence=; Reaction=all-trans-4-hydroxyretinoate + O2 + reduced [NADPH-- hemoprotein reductase] = all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:75851, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134178, ChEBI:CHEBI:134186; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75852; Evidence=; Reaction=9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:75847, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78630, ChEBI:CHEBI:139253; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75848; Evidence=; Reaction=9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:75855, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:139253, ChEBI:CHEBI:139254; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75856; Evidence=; Reaction=all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-oxo-13,14- dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:75859, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:194184, ChEBI:CHEBI:194478; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75860; Evidence=; Reaction=all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH-- hemoprotein reductase] = all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:75863, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:194183, ChEBI:CHEBI:194478; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75864; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Membrane ; Single-pass membrane protein During murine development it is initially expressed in the hindbrain and first branchial arch, while in late stages of embryogenesis, it can only be found in tooth buds and in inner ear structures (PubMed:12915310, PubMed:15872003). At E8.0, it is specifically expressed in prospective rhombomeres 2 (r2) and 4 (r4), and in the rostral portion of the first branchial arch (PubMed:12915310, PubMed:15872003). At E8.5 it is expressed in the mid- portion of the neuroepithelium of the prospective hindbrain and the branchial arch ectoderm (PubMed:12915310). By E9.5, its expression is observed in the maxillary and the mandibular components of the first branchial arch, in r2 and in the lateral epibranchial placodes (PubMed:12915310). By E10.5, it displays a specific pattern of expression in the cervical mesenchyme and is restricted to a few cells ventral to the pontine flexure (PubMed:12915310). By E11.5, its expression is confined only to a narrow band in the lateral cervical mesenchyme (PubMed:12915310). At E12.5, it is expressed along the mouth epithelium and at the level of the dental lamina, as well as in the cervical mesenchyme caudal to the otic vesicle (PubMed:12915310). By E14.5 there is strong expression in the dental epithelium (presumptive enamel organ), whereas it almost disappears from the mouth and tongue epithelium (PubMed:12915310). By E15, strongly expressed in a stripe across the retina (PubMed:15531370). At E16.5 expressed only in the enamel organ (specifically the inner dental epithelium) of the various tooth anlagen (PubMed:12915310). At E18.5 it is highly expressed in the second molar, but almost absent in the first molar epithelium (PubMed:12915310). Expression continues for several days postnatally, and persists longer in the temporal than nasal retina, disappearing around P14 (PubMed:15531370). The knockout presents no discernible embryological defects, however double homozygous mutants for Cyp26a1/c1 display a more severe RA embryopathy phenotype than either mutant alone, with lethality by E11.0. Among others, this includes CNS patterning abnormalities, a reduced size of the head, eye, frontonasal region and an open neural tube between the fore and hindbrain. Belongs to the cytochrome P450 family. C-22 sterol desaturase activity retinoic acid binding monooxygenase activity iron ion binding ergosterol biosynthetic process central nervous system development retinoic acid 4-hydroxylase activity anterior/posterior pattern specification neural crest cell development sterol metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding retinoic acid catabolic process metal ion binding organelle fusion oxidation-reduction process uc012ble.1 uc012ble.2 uc012ble.3 
ENSMUST00000073394.3 Usp17ld ENSMUST00000073394.3 ubiquitin specific peptidase 17-like D (from RefSeq NM_001001559.2) Dub2a ENSMUST00000073394.1 ENSMUST00000073394.2 G5E8G2 NM_001001559 Q923V2 Q923V3 U17PD_MOUSE Usp17ld uc009itk.1 uc009itk.2 uc009itk.3 Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Nucleus Endoplasmic reticulum Detected in T-cell, myeloid, and embryonic stem cell lines. Belongs to the peptidase C19 family. USP17 subfamily. cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus endoplasmic reticulum proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity regulation of apoptotic process uc009itk.1 uc009itk.2 uc009itk.3 
ENSMUST00000073415.2 Vmn1r48 ENSMUST00000073415.2 vomeronasal 1 receptor 48 (from RefSeq NM_053218.1) ENSMUST00000073415.1 NM_053218 Q9EQ52 V1R48_MOUSE V1ra3 V1ra6 uc009cws.1 uc009cws.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Cell membrane ; Multi-pass membrane protein Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc009cws.1 uc009cws.2 
ENSMUST00000073441.13 Smg7 ENSMUST00000073441.13 SMG7 nonsense mediated mRNA decay factor, transcript variant 3 (from RefSeq NM_001005507.2) ENSMUST00000073441.1 ENSMUST00000073441.10 ENSMUST00000073441.11 ENSMUST00000073441.12 ENSMUST00000073441.2 ENSMUST00000073441.3 ENSMUST00000073441.4 ENSMUST00000073441.5 ENSMUST00000073441.6 ENSMUST00000073441.7 ENSMUST00000073441.8 ENSMUST00000073441.9 Est1c Kiaa0250 NM_001005507 Q5RJH6 Q63ZW5 Q6ZQF3 SMG7_MOUSE Smg7 uc007czo.1 uc007czo.2 uc007czo.3 uc007czo.4 Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). Part of a complex that contains SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1 (By similarity). Interacts with DHX34; the interaction is RNA-independent (By similarity). Cytoplasm Nucleus Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5RJH6-1; Sequence=Displayed; Name=2; IsoId=Q5RJH6-2; Sequence=VSP_016577; Name=3; IsoId=Q5RJH6-3; Sequence=VSP_016578, VSP_016579; Sequence=BAC97911.1; Type=Erroneous initiation; Evidence=; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nucleus telomerase holoenzyme complex cytoplasm cytosol telomere maintenance via telomerase regulation of telomere maintenance via telomerase telomeric DNA binding intermediate filament cytoskeleton protein phosphatase 2A binding telomerase RNA binding uc007czo.1 uc007czo.2 uc007czo.3 uc007czo.4 
ENSMUST00000073447.8 Pcdhga3 ENSMUST00000073447.8 protocadherin gamma subfamily A, 3 (from RefSeq NM_033586.2) ENSMUST00000073447.1 ENSMUST00000073447.2 ENSMUST00000073447.3 ENSMUST00000073447.4 ENSMUST00000073447.5 ENSMUST00000073447.6 ENSMUST00000073447.7 NM_033586 Pcdhga3 Q91XY5 Q91XY5_MOUSE uc008eqn.1 uc008eqn.2 uc008eqn.3 uc008eqn.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding protein binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules endosome to lysosome transport membrane integral component of membrane lipid tube assembly involved in organelle fusion uc008eqn.1 uc008eqn.2 uc008eqn.3 uc008eqn.4 
ENSMUST00000073456.9 Nsa2 ENSMUST00000073456.9 NSA2 ribosome biogenesis homolog (from RefSeq NM_021552.5) A0JNU8 ENSMUST00000073456.1 ENSMUST00000073456.2 ENSMUST00000073456.3 ENSMUST00000073456.4 ENSMUST00000073456.5 ENSMUST00000073456.6 ENSMUST00000073456.7 ENSMUST00000073456.8 NM_021552 NSA2_MOUSE Q8BHQ6 Q8BHT0 Q9CR47 Q9CRQ0 Q9CS34 Q9CYK0 Q9JKF9 Tinp1 uc007rns.1 uc007rns.2 uc007rns.3 uc007rns.4 Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). Component of the pre-66S ribosomal particle. Nucleus, nucleolus Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily. Sequence=AAF63492.1; Type=Frameshift; Evidence=; nucleus nucleolus rRNA processing preribosome, large subunit precursor ribosome biogenesis uc007rns.1 uc007rns.2 uc007rns.3 uc007rns.4 
ENSMUST00000073459.12 Syt9 ENSMUST00000073459.12 synaptotagmin IX, transcript variant 4 (from RefSeq NR_184792.1) ENSMUST00000073459.1 ENSMUST00000073459.10 ENSMUST00000073459.11 ENSMUST00000073459.2 ENSMUST00000073459.3 ENSMUST00000073459.4 ENSMUST00000073459.5 ENSMUST00000073459.6 ENSMUST00000073459.7 ENSMUST00000073459.8 ENSMUST00000073459.9 NR_184792 Q3U0R7 Q8C280 Q9R0N9 SYT9_MOUSE Syt5 uc009jba.1 uc009jba.2 uc009jba.3 May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. ; Homodimer; disulfide-linked via the cysteine motif (PubMed:10531343). Can also form heterodimers with SYT3, SYT6, SYT7 and SYT10 (PubMed:10531343, PubMed:10531344, PubMed:10871604). Interacts with DNAJC5 and SNAP25, but not with HSC70 (PubMed:20847230). The interaction with DNAJC5 is stimulated tenfold in presence of calcium while the interaction with SNAP25 is inhibited (PubMed:20847230). Q9R0N9; Q9R0N4: Syt10; NbExp=2; IntAct=EBI-458006, EBI-5239459; Q9R0N9; O35681: Syt3; NbExp=2; IntAct=EBI-458006, EBI-457995; Q9R0N9; Q9R0N8: Syt6; NbExp=2; IntAct=EBI-458006, EBI-5239378; Q9R0N9; Q9R0N9: Syt9; NbExp=2; IntAct=EBI-458006, EBI-458006; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds. Belongs to the synaptotagmin family. SNARE binding phosphatidylserine binding calcium ion binding protein binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding plasma membrane regulation of dopamine secretion membrane integral component of membrane vesicle-mediated transport calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis syntaxin binding cell junction secretory granule clathrin binding integral component of synaptic vesicle membrane secretory granule membrane synaptic vesicle membrane dense core granule cytoplasmic vesicle identical protein binding synapse positive regulation of calcium ion-dependent exocytosis metal ion binding regulation of insulin secretion exocytic vesicle cellular response to calcium ion calcium-dependent activation of synaptic vesicle fusion uc009jba.1 uc009jba.2 uc009jba.3 
ENSMUST00000073466.13 Cryzl1 ENSMUST00000073466.13 crystallin zeta like 1, transcript variant 1 (from RefSeq NM_133679.2) ENSMUST00000073466.1 ENSMUST00000073466.10 ENSMUST00000073466.11 ENSMUST00000073466.12 ENSMUST00000073466.2 ENSMUST00000073466.3 ENSMUST00000073466.4 ENSMUST00000073466.5 ENSMUST00000073466.6 ENSMUST00000073466.7 ENSMUST00000073466.8 ENSMUST00000073466.9 NM_133679 Q3UKX2 Q8VCS1 Q921W4 Q9CWR9 QORL1_MOUSE uc007zyf.1 uc007zyf.2 uc007zyf.3 uc007zyf.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q921W4-1; Sequence=Displayed; Name=2; IsoId=Q921W4-2; Sequence=VSP_000209, VSP_000210; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. oxidoreductase activity oxidation-reduction process uc007zyf.1 uc007zyf.2 uc007zyf.3 uc007zyf.4 
ENSMUST00000073468.5 Or5ae1 ENSMUST00000073468.5 olfactory receptor family 5 subfamily AE member 1 (from RefSeq NM_146416.2) ENSMUST00000073468.1 ENSMUST00000073468.2 ENSMUST00000073468.3 ENSMUST00000073468.4 NM_146416 Olfr290 Or5ae1 Q7TS13 Q7TS13_MOUSE uc009ieq.1 uc009ieq.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC127990.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ieq.1 uc009ieq.2 
ENSMUST00000073471.13 Rpl26 ENSMUST00000073471.13 ribosomal protein L26 (from RefSeq NM_009080.2) ENSMUST00000073471.1 ENSMUST00000073471.10 ENSMUST00000073471.11 ENSMUST00000073471.12 ENSMUST00000073471.2 ENSMUST00000073471.3 ENSMUST00000073471.4 ENSMUST00000073471.5 ENSMUST00000073471.6 ENSMUST00000073471.7 ENSMUST00000073471.8 ENSMUST00000073471.9 NM_009080 Q4FZH2 Q4FZH2_MOUSE Rpl26 uc007joh.1 uc007joh.2 uc007joh.3 Belongs to the universal ribosomal protein uL24 family. structural constituent of ribosome ribosome translation large ribosomal subunit uc007joh.1 uc007joh.2 uc007joh.3 
ENSMUST00000073488.12 Nr1h2 ENSMUST00000073488.12 nuclear receptor subfamily 1, group H, member 2, transcript variant 1 (from RefSeq NM_009473.4) ENSMUST00000073488.1 ENSMUST00000073488.10 ENSMUST00000073488.11 ENSMUST00000073488.2 ENSMUST00000073488.3 ENSMUST00000073488.4 ENSMUST00000073488.5 ENSMUST00000073488.6 ENSMUST00000073488.7 ENSMUST00000073488.8 ENSMUST00000073488.9 Lxrb NM_009473 NR1H2_MOUSE Q60644 Rip15 Unr Unr2 uc009gqa.1 uc009gqa.2 uc009gqa.3 uc009gqa.4 Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4) (PubMed:18055760, PubMed:19520913, PubMed:20427281). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8 (PubMed:18055760, PubMed:19520913, PubMed:20427281). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (PubMed:18055760, PubMed:19520913, PubMed:20427281, PubMed:24206663, PubMed:28846071). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (PubMed:28846071, PubMed:25806685). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (PubMed:25806685). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (PubMed:24206663). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity). Forms a heterodimer with RXR. Interacts with CCAR2 (via N- terminus) in a ligand-independent manner. Interacts (when sumoylated) with GPS2; interaction with GPS2 onto hepatic acute phase protein promoters prevents N-Cor corepressor complex dissociation (By similarity). Interacts with ABCA12 and ABCA1; this interaction is required for ABCA1 localization to the cell surface and is necessary for its normal activity and stability (By similarity). Q60644; Q96EB6: SIRT1; Xeno; NbExp=2; IntAct=EBI-5276809, EBI-1802965; Nucleus Ubiquitous. Sumoylated by SUMO2 at Lys-395 and Lys-433 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation. Belongs to the nuclear hormone receptor family. NR1 subfamily. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter lipid metabolic process multicellular organism development transcription factor binding zinc ion binding positive regulation of gene expression negative regulation of gene expression positive regulation of triglyceride biosynthetic process positive regulation of cholesterol efflux positive regulation of lipid storage negative regulation of cholesterol storage cell differentiation ligand-dependent nuclear receptor transcription coactivator activity positive regulation of cellular protein metabolic process negative regulation of lipid transport positive regulation of cholesterol transport apolipoprotein A-I receptor binding signaling receptor activity cholesterol homeostasis steroid hormone mediated signaling pathway sequence-specific DNA binding cellular lipid metabolic process positive regulation of fatty acid biosynthetic process negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding retinoid X receptor binding retinoic acid receptor signaling pathway negative regulation of pinocytosis positive regulation of lipoprotein lipase activity ATPase binding lipid homeostasis cellular response to lipopolysaccharide positive regulation of high-density lipoprotein particle assembly positive regulation of pancreatic juice secretion positive regulation of secretion of lysosomal enzymes RNA polymerase II transcription factor complex uc009gqa.1 uc009gqa.2 uc009gqa.3 uc009gqa.4 
ENSMUST00000073490.7 Lct ENSMUST00000073490.7 lactase (from RefSeq NM_001081078.2) ENSMUST00000073490.1 ENSMUST00000073490.2 ENSMUST00000073490.3 ENSMUST00000073490.4 ENSMUST00000073490.5 ENSMUST00000073490.6 F8VPT3 F8VPT3_MOUSE Lct NM_001081078 uc007clm.1 uc007clm.2 uc007clm.3 lactase activity response to hypoxia hydrolase activity, hydrolyzing O-glycosyl compounds brush border carbohydrate metabolic process response to nutrient metabolic process beta-glucosidase activity response to organic substance response to iron(II) ion response to nickel cation response to lead ion membrane integral component of membrane transferase activity hydrolase activity hydrolase activity, acting on glycosyl bonds response to drug response to ethanol uc007clm.1 uc007clm.2 uc007clm.3 
ENSMUST00000073521.12 Nudt7 ENSMUST00000073521.12 nudix hydrolase 7, transcript variant 1 (from RefSeq NM_024437.4) ENSMUST00000073521.1 ENSMUST00000073521.10 ENSMUST00000073521.11 ENSMUST00000073521.2 ENSMUST00000073521.3 ENSMUST00000073521.4 ENSMUST00000073521.5 ENSMUST00000073521.6 ENSMUST00000073521.7 ENSMUST00000073521.8 ENSMUST00000073521.9 NM_024437 NUDT7_MOUSE Nudt7 Q6IS65 Q8BU08 Q8K260 Q99P30 Q9D0Q3 Q9DBI9 uc009nnw.1 uc009nnw.2 uc009nnw.3 uc009nnw.4 uc009nnw.5 Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'- bisphosphate (PubMed:11415433, PubMed:18799520, PubMed:29378847). Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (PubMed:11415433). Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (PubMed:18799520). Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester (PubMed:18799520). May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (PubMed:18799520). Does not play a role in U8 snoRNA decapping activity (PubMed:21070968). Binds U8 snoRNA (PubMed:21070968). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673). Reaction=H2O + hexanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:49980, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58343, ChEBI:CHEBI:62620, ChEBI:CHEBI:132012; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49981; Evidence=; Reaction=H2O + octanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50016, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57386, ChEBI:CHEBI:58343, ChEBI:CHEBI:132013; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50017; Evidence=; Reaction=butanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:49976, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57371, ChEBI:CHEBI:58343, ChEBI:CHEBI:132011; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49977; Evidence=; Reaction=decanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + decanoyl- 4'-phosphopantetheine + 2 H(+); Xref=Rhea:RHEA:50020, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58343, ChEBI:CHEBI:61430, ChEBI:CHEBI:132014; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50021; Evidence=; Reaction=dodecanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50024, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57375, ChEBI:CHEBI:58343, ChEBI:CHEBI:132015; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50025; Evidence=; Reaction=H2O + tetradecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50028, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57385, ChEBI:CHEBI:58343, ChEBI:CHEBI:132017; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50029; Evidence=; Reaction=choloyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S- choloyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50036, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57373, ChEBI:CHEBI:58343, ChEBI:CHEBI:132020; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50037; Evidence=; Reaction=3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'- phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+); Xref=Rhea:RHEA:50040, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58343, ChEBI:CHEBI:63001, ChEBI:CHEBI:132021; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50041; Evidence=; Reaction=acetyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S- acetyl-4'-phosphopantetheine; Xref=Rhea:RHEA:64992, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57288, ChEBI:CHEBI:58343, ChEBI:CHEBI:156266; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64993; Evidence=; Reaction=CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'- bisphosphate + 2 H(+); Xref=Rhea:RHEA:64988, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58343, ChEBI:CHEBI:61723; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64989; Evidence=; Reaction=H2O + propanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:67464, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57392, ChEBI:CHEBI:58343, ChEBI:CHEBI:172362; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67465; Evidence=; Reaction=H2O + malonyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine; Xref=Rhea:RHEA:67468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57384, ChEBI:CHEBI:58343, ChEBI:CHEBI:172363; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67469; Evidence=; Reaction=H2O + succinyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine; Xref=Rhea:RHEA:67472, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57292, ChEBI:CHEBI:58343, ChEBI:CHEBI:172364; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67473; Evidence=; Reaction=a 5'-end CoA-ribonucleoside in mRNA + H2O = (R)-4'- phosphopantetheine + a 5'-end phospho-adenosine-phospho- ribonucleoside in mRNA + 2 H(+); Xref=Rhea:RHEA:67592, Rhea:RHEA- COMP:15719, Rhea:RHEA-COMP:17276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:61723, ChEBI:CHEBI:144051, ChEBI:CHEBI:172371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67593; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by fluoride. Kinetic parameters: KM=0.240 mM for CoA ; KM=0.157 mM for CoA ; KM=0.270 mM for acetyl-CoA ; KM=92.6 uM for hexanoyl-CoA ; KM=62.6 uM for octanoyl-CoA ; KM=34 uM for tetradecanoyl-CoA ; KM=157.9 uM for butanoyl-CoA ; KM=242 uM for decanoyl-CoA ; KM=22.4 uM for dodecanoyl-CoA ; KM=221.4 uM for propionyl-CoA ; KM=28.7 uM for palmitoyl-CoA ; KM=0.430 mM for acetyl-CoA ; KM=0.235 mM for CoA-S-S-CoA ; KM=0.330 mM for succinyl-CoA ; KM=0.480 mM for 3'-dephospho-CoA ; KM=283 uM for CoA ; Vmax=0.13 umol/min/mg enzyme toward CoA ; Vmax=0.27 umol/min/mg enzyme toward acetyl-CoA ; Vmax=0.33 umol/min/mg enzyme toward propionyl-CoA ; Vmax=0.49 umol/min/mg enzyme toward butanoyl-CoA ; Vmax=0.83 umol/min/mg enzyme toward hexanoyl-CoA ; Vmax=1.08 umol/min/mg enzyme toward octanoyl-CoA ; Vmax=1.84 umol/min/mg enzyme toward decanoyl-CoA ; Vmax=1.06 umol/min/mg enzyme toward dodecanoyl-CoA ; Vmax=0.41 umol/min/mg enzyme toward tetradecanoyl-CoA ; Vmax=0.15 umol/min/mg enzyme toward palmitoyl-CoA ; pH dependence: Optimum pH is 8. ; Monomer. Peroxisome Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Alpha, Nudt7alpha ; IsoId=Q99P30-1; Sequence=Displayed; Name=2; Synonyms=Beta, Nudt7beta, Nudt7gamma ; IsoId=Q99P30-2; Sequence=VSP_014272; Name=3; IsoId=Q99P30-3; Sequence=VSP_014273; Name=4; IsoId=Q99P30-4; Sequence=VSP_014271; Name=5; IsoId=Q99P30-5; Sequence=VSP_014274, VSP_014275; [Isoform 1]: Highly expressed in liver, brown adipose tissue and heart. Expressed at intermediate level in lung and kidney and at low level in brain. [Isoform 2]: Expressed in liver, brown adipose tissue and heart at 20 times lower levels than isoform 1. [Isoform 1]: Expression decreases in response to peroxisome proliferators. [Isoform 2]: Inactive. Belongs to the Nudix hydrolase family. PCD1 subfamily. Sequence=AAH33046.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; magnesium ion binding RNA binding acetyl-CoA hydrolase activity peroxisome nucleoside diphosphate metabolic process coenzyme A catabolic process hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides manganese ion binding snoRNA binding acetyl-CoA catabolic process metal ion binding brown fat cell differentiation m7G(5')pppN diphosphatase activity uc009nnw.1 uc009nnw.2 uc009nnw.3 uc009nnw.4 uc009nnw.5 
ENSMUST00000073527.13 Thsd7b ENSMUST00000073527.13 thrombospondin, type I, domain containing 7B (from RefSeq NM_172485.3) ENSMUST00000073527.1 ENSMUST00000073527.10 ENSMUST00000073527.11 ENSMUST00000073527.12 ENSMUST00000073527.2 ENSMUST00000073527.3 ENSMUST00000073527.4 ENSMUST00000073527.5 ENSMUST00000073527.6 ENSMUST00000073527.7 ENSMUST00000073527.8 ENSMUST00000073527.9 NM_172485 Q6P4U0 THS7B_MOUSE Thsd7b uc007clv.1 uc007clv.2 uc007clv.3 uc007clv.4 Membrane ; Single-pass type I membrane protein molecular_function plasma membrane membrane integral component of membrane actin cytoskeleton reorganization uc007clv.1 uc007clv.2 uc007clv.3 uc007clv.4 
ENSMUST00000073528.4 Zar1 ENSMUST00000073528.4 zygote arrest 1, transcript variant 1 (from RefSeq NM_174877.3) ENSMUST00000073528.1 ENSMUST00000073528.2 ENSMUST00000073528.3 NM_174877 Q4FZK8 Q80SU3 ZAR1_MOUSE Zar1 uc008xrp.1 uc008xrp.2 uc008xrp.3 mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes (PubMed:36264786). MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth (PubMed:36264786). Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (PubMed:36264786). Binds to the 3'-UTR of maternal mRNAs (PubMed:31598710). Maternal mRNAs stored in the MARDO are translationally repressed (PubMed:36264786). Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation (PubMed:12539046, PubMed:31598710, PubMed:36264786). Interacts with YBX2. Cytoplasm, Cytoplasmic ribonucleoprotein granule Cytoplasm Note=Specifically localizes to MARDO (mitochondria-associated ribonucleoprotein domain), a mitochondria- associated membraneless compartment that stores mRNAs in oocytes. Ovary (PubMed:12539046, PubMed:12773403). Expressed in primary oocytes (from primary through antral follicle stages) and during the progression from Meiosis I to Meiosis II (PubMed:12539046, PubMed:12773403, PubMed:31598710). The mRNA is detected in growing oocytes (early primary follicle, type 3a) through fully grown oocytes (antral follicle, type 8) (PubMed:12539046, PubMed:12773403). Expressed in zygote at the one-cell embryo, markedly less abundant at the two-cell embryo. Disordered region at the N-terminus undergoes liquid-liquid phase separation (LLPS) for the formation of MARDO (mitochondria- associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. The 3CxxC-type mediates binding to the 3'-UTR of mRNAs. Phosphorylation by CDK1 does not regulate formation of MARDO (mitochondria-associated ribonucleoprotein domain) membraneless compartment. Ubiquitinated and degradaded by the proteasome during oocyte meiotic maturation, leading to MARDO (mitochondria-associated ribonucleoprotein domain) membraneless compartment dissolution. Mice are viable but females are infertile (PubMed:12539046). Ovarian development and oogenesis through the early stages of fertilization are normal, but most embryos from mutant females arrest at the one-cell stage (PubMed:12539046, PubMed:36264786). Abolished formation of MARDO phase-separated membraneless compartment and mitochondrial clustering in oocytes (PubMed:36264786). Mice lacking Zar1 and Zar1l oocytes display delayed meiotic resumption and polar body-1 emission and a higher incidence of abnormal meiotic spindle formation and chromosome aneuploidy (PubMed:31598710). The grown oocytes of Zar1 and Zar1l mutant mice contain decreased levels of many maternal mRNAs and display a reduced level of protein synthesis (PubMed:31598710). Belongs to the ZAR1 family. Name=Protein Spotlight; Note=In good time - Issue 261 of September 2023; URL="https://www.proteinspotlight.org/back_issues/261/"; molecular_function cytoplasm multicellular organism development biological_process uc008xrp.1 uc008xrp.2 uc008xrp.3 
ENSMUST00000073532.5 Pramel23 ENSMUST00000073532.5 PRAME like 23 (from RefSeq NM_001356572.1) A2AGW7 A2AGW7_MOUSE ENSMUST00000073532.1 ENSMUST00000073532.2 ENSMUST00000073532.3 ENSMUST00000073532.4 NM_001356572 Pramel23 uc008vqj.1 uc008vqj.2 uc008vqj.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vqj.1 uc008vqj.2 uc008vqj.3 
ENSMUST00000073534.10 Zfp523 ENSMUST00000073534.10 zinc finger protein 523, transcript variant 8 (from RefSeq NR_182186.1) ENSMUST00000073534.1 ENSMUST00000073534.2 ENSMUST00000073534.3 ENSMUST00000073534.4 ENSMUST00000073534.5 ENSMUST00000073534.6 ENSMUST00000073534.7 ENSMUST00000073534.8 ENSMUST00000073534.9 NR_182186 Q6P9T2 Q8BMU0 ZNF76_MOUSE Znf76 uc289iwt.1 uc289iwt.2 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BMU0-1; Sequence=Displayed; Name=2; IsoId=Q8BMU0-2; Sequence=VSP_035628, VSP_035629; Belongs to the krueppel C2H2-type zinc-finger protein family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding protein binding nucleus central nervous system development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc289iwt.1 uc289iwt.2 
ENSMUST00000073536.13 Nrap ENSMUST00000073536.13 nebulin-related anchoring protein, transcript variant 2 (from RefSeq NM_008733.5) E9QN76 ENSMUST00000073536.1 ENSMUST00000073536.10 ENSMUST00000073536.11 ENSMUST00000073536.12 ENSMUST00000073536.2 ENSMUST00000073536.3 ENSMUST00000073536.4 ENSMUST00000073536.5 ENSMUST00000073536.6 ENSMUST00000073536.7 ENSMUST00000073536.8 ENSMUST00000073536.9 NM_008733 NRAP_MOUSE Nrap O35884 Q3UTY7 Q3UU10 Q80V40 Q80XB4 uc008hyu.1 uc008hyu.2 uc008hyu.3 uc008hyu.4 uc008hyu.5 May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. Interacts with actin, alpha-actinin, KLHL41, TLN1 and VCL. Interacts with CSRP3. Note=Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle. Event=Alternative splicing; Named isoforms=4; Name=1 ; Synonyms=S ; IsoId=Q80XB4-1; Sequence=Displayed; Name=2 ; Synonyms=C ; IsoId=Q80XB4-2; Sequence=VSP_052160; Name=3 ; IsoId=Q80XB4-3; Sequence=VSP_052160, VSP_052162; Name=4 ; IsoId=Q80XB4-4; Sequence=VSP_052159, VSP_052160; Expressed in cardiac and skeletal muscle. Not detected in kidney, spleen, liver, brain, lung, stomach or uterus. Expression significantly increased from 10.5 dpc to 16.5 dpc, and subsequently remained constant until 21 days after birth. In 9.5 dpc to 10.5 dpc embryonic heart, expression is primarily associated with developing premyofibril structures containing alpha- actinin. Sequence=AAC53323.1; Type=Frameshift; Evidence=; actin binding protein binding fascia adherens muscle tendon junction vinculin binding myofibril Z disc actin cytoskeleton organization metal ion binding muscle fiber development actin filament binding muscle alpha-actinin binding cardiac muscle thin filament assembly uc008hyu.1 uc008hyu.2 uc008hyu.3 uc008hyu.4 uc008hyu.5 
ENSMUST00000073543.2 Or1x6 ENSMUST00000073543.2 olfactory receptor family 1 subfamily X member 6 (from RefSeq NM_146516.2) A0A0N4SUP0 A0A0N4SUP0_MOUSE ENSMUST00000073543.1 NM_146516 Olfr1375 Olfr1375-ps1 Or1x6 uc057ayh.1 uc057ayh.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc057ayh.1 uc057ayh.2 
ENSMUST00000073546.5 H2-M10.3 ENSMUST00000073546.5 histocompatibility 2, M region locus 10.3 (from RefSeq NM_201608.2) ENSMUST00000073546.1 ENSMUST00000073546.2 ENSMUST00000073546.3 ENSMUST00000073546.4 H2-M10.3 NM_201608 Q85ZW6 Q85ZW6_MOUSE uc008ckz.1 uc008ckz.2 uc008ckz.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc008ckz.1 uc008ckz.2 uc008ckz.3 
ENSMUST00000073554.4 Cytl1 ENSMUST00000073554.4 cytokine-like 1 (from RefSeq NM_001081106.1) 4Cytl1 A1E5L0 A1E5L0_MOUSE Cytl1 ENSMUST00000073554.1 ENSMUST00000073554.2 ENSMUST00000073554.3 NM_001081106 uc008xfu.1 uc008xfu.2 chondrocyte differentiation cellular_component positive regulation of transcription from RNA polymerase II promoter inner ear development chondroitin sulfate proteoglycan biosynthetic process positive regulation of sequence-specific DNA binding transcription factor activity cartilage homeostasis uc008xfu.1 uc008xfu.2 
ENSMUST00000073556.12 Mdga1 ENSMUST00000073556.12 MAM domain containing glycosylphosphatidylinositol anchor 1, transcript variant 2 (from RefSeq NM_001081160.1) D3Z499 D3Z499_MOUSE ENSMUST00000073556.1 ENSMUST00000073556.10 ENSMUST00000073556.11 ENSMUST00000073556.2 ENSMUST00000073556.3 ENSMUST00000073556.4 ENSMUST00000073556.5 ENSMUST00000073556.6 ENSMUST00000073556.7 ENSMUST00000073556.8 ENSMUST00000073556.9 Mdga1 NM_001081160 uc008bto.1 uc008bto.2 Cell membrane ; Lipid-anchor, GPI-anchor Membrane ; Lipid-anchor, GPI-anchor membrane anchored component of plasma membrane GABA-ergic synapse regulation of presynapse assembly uc008bto.1 uc008bto.2 
ENSMUST00000073572.12 Mtx1 ENSMUST00000073572.12 metaxin 1, transcript variant 1 (from RefSeq NM_013604.3) E9Q6T4 ENSMUST00000073572.1 ENSMUST00000073572.10 ENSMUST00000073572.11 ENSMUST00000073572.2 ENSMUST00000073572.3 ENSMUST00000073572.4 ENSMUST00000073572.5 ENSMUST00000073572.6 ENSMUST00000073572.7 ENSMUST00000073572.8 ENSMUST00000073572.9 F7C846 Mtx1 NM_013604 Q8R5C0 Q8R5C0_MOUSE uc008pye.1 uc008pye.2 uc008pye.3 uc008pye.4 Involved in transport of proteins into the mitochondrion. Essential for embryonic development. Membrane Mitochondrion outer membrane Belongs to the metaxin family. mitochondrial sorting and assembly machinery complex membrane integral component of membrane uc008pye.1 uc008pye.2 uc008pye.3 uc008pye.4 
ENSMUST00000073575.12 Slc39a13 ENSMUST00000073575.12 solute carrier family 39 (metal ion transporter), member 13, transcript variant 2 (from RefSeq NM_026721.4) B7ZCF2 ENSMUST00000073575.1 ENSMUST00000073575.10 ENSMUST00000073575.11 ENSMUST00000073575.2 ENSMUST00000073575.3 ENSMUST00000073575.4 ENSMUST00000073575.5 ENSMUST00000073575.6 ENSMUST00000073575.7 ENSMUST00000073575.8 ENSMUST00000073575.9 NM_026721 Q497M5 Q8BZH0 Q8VDX1 Q9D1R4 S39AD_MOUSE Slc39a13 Zip13 uc008kug.1 uc008kug.2 uc008kug.3 uc008kug.4 Functions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol (PubMed:18985159). May regulate beige adipocyte differentiation (PubMed:28854265). Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence=; Homodimer. Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane Endoplasmic reticulum membrane Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BZH0-1; Sequence=Displayed; Name=2; IsoId=Q8BZH0-2; Sequence=VSP_029821; Name=3; IsoId=Q8BZH0-3; Sequence=VSP_029820, VSP_029822; Highly expressed in some tissues such as bone and eye (PubMed:18985159). Expressed in osteoblasts of tibia and of alveolar bone, in proliferative zone of growth plate, and in odontoblasts on the forming of the dentine of crown in molar tooth (PubMed:18985159). Also expressed fibroblasts in reticular layer of dermis of skin (PubMed:18985159). Homozygous knockout mice for Slc39a13 show growth retardation and results in a generalized skeletal and connective tissue disorder, namely develop progressive kyphosis after 3 or 4 weeks of age. Belongs to the ZIP transporter (TC 2.A.5) family. Golgi membrane zinc ion transmembrane transporter activity endoplasmic reticulum Golgi apparatus ion transport zinc II ion transport cellular zinc ion homeostasis response to zinc ion membrane integral component of membrane metal ion transport protein homodimerization activity metal ion transmembrane transporter activity perinuclear region of cytoplasm transmembrane transport connective tissue development zinc II ion transmembrane transport uc008kug.1 uc008kug.2 uc008kug.3 uc008kug.4 
ENSMUST00000073600.9 Errfi1 ENSMUST00000073600.9 ERBB receptor feedback inhibitor 1, transcript variant 1 (from RefSeq NM_001356323.1) ENSMUST00000073600.1 ENSMUST00000073600.2 ENSMUST00000073600.3 ENSMUST00000073600.4 ENSMUST00000073600.5 ENSMUST00000073600.6 ENSMUST00000073600.7 ENSMUST00000073600.8 ERRFI_MOUSE Mig6 NM_001356323 Q99JZ7 uc008vxw.1 uc008vxw.2 uc008vxw.3 Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development. Interacts with EGFR (By similarity). Interacts with ERBB2. Q99JZ7; Q60631: Grb2; NbExp=3; IntAct=EBI-643375, EBI-1688; Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes. Detected in lung, in airway epithelial cells and alveolar type 2 cells (at protein level). Detected in uterus stroma, luminal epithelium and glandular epithelium. Detected at low levels during embryogenesis. Strongly up-regulated during the first days after birth. Levels are increased on the first day after birth, and culminate three days after birth. Detected at low levels four days after birth, and throughout the remaining life span. Up-regulated by lysophosphatidic acid (LPA) and sphingosine 1-phosphate. Up-regulated by globular actin monomers, via MKL1 signaling. Up-regulated in uterus in response to progesterone. Up- regulated in uterus in response to estrogen. Up-regulated in pregnant uterus. The EGFR-binding region prevents binding of a cyclin-like activator to the EGFR kinase domain, and thereby keeps EGFR in an inactive conformation. Also maintains EGFR in an inactive conformation by preventing formation of an asymmetric homodimer (By similarity). Embryos are present at the expected Mendelian ratio, but half of the mice die before adolescence, due to defects in prenatal and perinatal lung development. In the 15.5 dpc embryo, lungs are smaller, have a less complex structure than normal, and present fewer blood vessels. Lungs in newborns present abnormal patterns of cell proliferation and apoptosis. Adults develop chronic obstructive pulmonary disease (COPD). Mice present epidermal hyperplasia with thickening and flaking skin and ulcerations on tail and footpads. Papillomas develop at sites of wounding. Mice are highly susceptible to chemical carcinogens and develop melanomas and/or papillomas after application of a carcinogen. They have a high incidence of spontaneous hyperplastic and neoplastic lesions, such as adenocarcinomas or squamous cell carcinomas. They present bone and cartilage hyperplasia, leading to fixed joints. Mice have altered response to progesterone in the uterus, resulting in endometrial epithelial hyperplasia and complete loss of fertility. Mice have a shortened life span and die prematurely at an age of five to seven months. Belongs to the MIG6 family. protein binding nucleus cytoplasm cytosol plasma membrane negative regulation of epidermal growth factor-activated receptor activity membrane SH3 domain binding kinase binding protein kinase binding stress-activated protein kinase signaling cascade extrinsic component of cytoplasmic side of plasma membrane small GTPase binding negative regulation of protein autophosphorylation negative regulation of interleukin-1 beta production cellular response to insulin stimulus negative regulation of collagen biosynthetic process cellular response to platelet-derived growth factor stimulus negative regulation of epidermal growth factor receptor signaling pathway negative regulation of tumor necrosis factor biosynthetic process skin morphogenesis regulation of keratinocyte differentiation lung alveolus development negative regulation of peptidyl-tyrosine phosphorylation lung vasculature development lung epithelium development regulation of type B pancreatic cell proliferation negative regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus cellular hyperosmotic response cellular response to dexamethasone stimulus negative regulation of cardiac muscle hypertrophy in response to stress uc008vxw.1 uc008vxw.2 uc008vxw.3 
ENSMUST00000073601.5 Prl3d3 ENSMUST00000073601.5 prolactin family 3, subfamily d, member 3, transcript variant 1 (from RefSeq NM_172156.3) ENSMUST00000073601.1 ENSMUST00000073601.2 ENSMUST00000073601.3 ENSMUST00000073601.4 NM_172156 Plig Prl3d3 Q8CGZ7 Q8CGZ7_MOUSE uc007pxg.1 uc007pxg.2 uc007pxg.3 Secreted Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pxg.1 uc007pxg.2 uc007pxg.3 
ENSMUST00000073605.15 Gapdh ENSMUST00000073605.15 Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:19903941). Glyceraldehyde-3- phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3- phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:19903941). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon- activated inhibitor of translation) complex which mediates interferon- gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). (from UniProt P16858) A6H6A8 AK144690 ENSMUST00000073605.1 ENSMUST00000073605.10 ENSMUST00000073605.11 ENSMUST00000073605.12 ENSMUST00000073605.13 ENSMUST00000073605.14 ENSMUST00000073605.2 ENSMUST00000073605.3 ENSMUST00000073605.4 ENSMUST00000073605.5 ENSMUST00000073605.6 ENSMUST00000073605.7 ENSMUST00000073605.8 ENSMUST00000073605.9 G3P_MOUSE Gapd P16858 Q0QEU0 Q3THM2 Q3TUI2 Q3UMT2 Q4V783 Q569X2 Q569X5 Q5U410 uc291izi.1 uc291izi.2 Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:19903941). Glyceraldehyde-3- phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3- phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:19903941). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon- activated inhibitor of translation) complex which mediates interferon- gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Reaction=D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3- phospho-glyceroyl phosphate + H(+) + NADH; Xref=Rhea:RHEA:10300, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57540, ChEBI:CHEBI:57604, ChEBI:CHEBI:57945, ChEBI:CHEBI:59776; EC=1.2.1.12; Evidence= Reaction=L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] = L- cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]; Xref=Rhea:RHEA:66684, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:17089, Rhea:RHEA-COMP:17090, Rhea:RHEA-COMP:17091, ChEBI:CHEBI:29950, ChEBI:CHEBI:149494; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66685; Evidence=; Glyceraldehyde-3-phosphate dehydrogenase activity is inhibited by fumarate, via the formation of S-(2-succinyl)cysteine residues. Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 1/5. Homotetramer (PubMed:23071094). Interacts with TPPP; the interaction is direct (By similarity). Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules. Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS1. Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)) (By similarity). Component of the GAIT complex. Interacts with FKBP6; leading to inhibit GAPDH catalytic activity (PubMed:23071094). Interacts with TRAF2, promoting TRAF2 ubiquitination (By similarity). Interacts with TRAF3, promoting TRAF3 ubiquitination (By similarity). P16858; P23819: Gria2; NbExp=2; IntAct=EBI-444871, EBI-77538; P16858; Q08460: Kcnma1; NbExp=3; IntAct=EBI-444871, EBI-1633915; Cytoplasm, cytosol Cytoplasm, cytoskeleton Nucleus Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. Colocalizes with CHP1 to small punctate structures along the microtubules tracks. The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex. ISGylated. S-nitrosylation of Cys-150 leads to interaction with SIAH1, followed by translocation to the nucleus S-nitrosylation of Cys-245 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity (By similarity). Sulfhydration at Cys-150 increases catalytic activity. Oxidative stress can promote the formation of high molecular weight disulfide-linked GAPDH aggregates, through a process called nucleocytoplasmic coagulation. Succination of Cys-150 and Cys-245 by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits glyceraldehyde-3-phosphate dehydrogenase activity. Fumarate concentration as well as succination of cysteine residues in GAPDH is significantly increased in muscle of diabetic mammals. It was proposed that the S-(2-succinyl)cysteine chemical modification may be a useful biomarker of mitochondrial and oxidative stress in diabetes and that succination of GAPDH and other thiol proteins by fumarate may contribute to the metabolic changes underlying the development of diabetes complications. Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. microtubule cytoskeleton organization glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity protein binding nucleus cytoplasm mitochondrion lipid particle cytosol cytoskeleton plasma membrane carbohydrate metabolic process glucose metabolic process gluconeogenesis glycolytic process regulation of translation apoptotic process multicellular organism development microtubule binding negative regulation of endopeptidase activity microtubule cytoskeleton oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor transferase activity negative regulation of translation aspartic-type endopeptidase inhibitor activity enzyme binding cAMP-mediated signaling killing of cells of other organism nuclear membrane peptidyl-cysteine S-nitrosylase activity peptidyl-cysteine S-trans-nitrosylation identical protein binding protein homodimerization activity myelin sheath intracellular membrane-bounded organelle NADP binding positive regulation of cytokine secretion protein stabilization defense response to fungus NAD binding protein homotetramerization neuron apoptotic process killing by host of symbiont cells positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction oxidation-reduction process response to ammonium ion cellular response to interferon-gamma GAIT complex disordered domain specific binding glutamatergic synapse postsynaptic density, intracellular component negative regulation of vascular associated smooth muscle cell apoptotic process ribonucleoprotein complex uc291izi.1 uc291izi.2 
ENSMUST00000073612.7 Or10ad1b ENSMUST00000073612.7 olfactory receptor family 10 subfamily AD member 1B (from RefSeq NM_001011779.1) A0A2I3BRI6 A0A2I3BRI6_MOUSE ENSMUST00000073612.1 ENSMUST00000073612.2 ENSMUST00000073612.3 ENSMUST00000073612.4 ENSMUST00000073612.5 ENSMUST00000073612.6 NM_001011779 Olfr286 Or10ad1b uc289bac.1 uc289bac.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. ##Evidence-Data-START## Transcript exon combination :: DR065569.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289bac.1 uc289bac.2 
ENSMUST00000073617.5 Glipr1l1 ENSMUST00000073617.5 GLI pathogenesis-related 1 like 1 (from RefSeq NM_027018.1) ENSMUST00000073617.1 ENSMUST00000073617.2 ENSMUST00000073617.3 ENSMUST00000073617.4 GPRL1_MOUSE Glipr1l1 NM_027018 Q9DAG6 uc007hak.1 uc007hak.2 uc007hak.3 Required for optimal fertilization at the stage of sperm- oocyte fusion, plays a role in optimizing acrosome function, the translocation of IZUMO1 during the acrosome reaction and the fertilization process (PubMed:20219979, PubMed:31672133). Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region. Part of a oolemmal binding multimeric complex (IZUMO1 complex) composed at least of IZUMO1 and GLIPR1L1; the complex assemblage is influenced by the maturation status of the male germ cell (PubMed:31672133). Interacts with IZUMO1 (PubMed:31672133). Cytoplasmic vesicle, secretory vesicle, acrosome Cell membrane ; Peripheral membrane protein ; Extracellular side Membrane raft Secreted Note=Located in the connecting piece of elongated spermatids and sperm (PubMed:20219979, PubMed:31672133). Also located in the apical region of the sperm head after sperm capacitation (PubMed:20219979, PubMed:31672133). Weakly attached to the cell membrane and later secreted into the extracellular space (PubMed:20219979). Located on sperm equatorial segment and neck (By similarity). Associated with epididymosomes from the caput and cauda epididymis (By similarity). Expressed in testis (at protein level). Little or no expression in other tissues tested. Detected at postnatal day 14 in developing testis (at protein level). Detected from postnatal day 18 onwards, with increasing levels through to postnatal day 36. N-glycosylated (PubMed:20219979). N-glycosylation decreases during the transit in the caput. Mutants have normal number of pups per litter, body weight, testis weight and daily sperm production (PubMed:31672133). Mutant sperm have a significantly reduced ability to undergo the progesterone-induced acrosome reaction compared to wild type (PubMed:31672133). Belongs to the CRISP family. acrosomal vesicle molecular_function extracellular region extracellular space plasma membrane single fertilization binding of sperm to zona pellucida membrane cytoplasmic vesicle membrane raft sperm connecting piece uc007hak.1 uc007hak.2 uc007hak.3 
ENSMUST00000073639.6 Rdh1 ENSMUST00000073639.6 retinol dehydrogenase 1 (all trans) (from RefSeq NM_080436.3) ENSMUST00000073639.1 ENSMUST00000073639.2 ENSMUST00000073639.3 ENSMUST00000073639.4 ENSMUST00000073639.5 NM_080436 Q8CGV4 Q8CGV4_MOUSE Rdh1 uc007hkn.1 uc007hkn.2 uc007hkn.3 uc007hkn.4 Belongs to the short-chain dehydrogenases/reductases (SDR) family. retinoid metabolic process retinol dehydrogenase activity endoplasmic reticulum membrane steroid metabolic process steroid dehydrogenase activity oxidoreductase activity integral component of organelle membrane intracellular membrane-bounded organelle androsterone dehydrogenase activity androstan-3-alpha,17-beta-diol dehydrogenase activity oxidation-reduction process uc007hkn.1 uc007hkn.2 uc007hkn.3 uc007hkn.4 
ENSMUST00000073641.4 Oog4 ENSMUST00000073641.4 oogenesin 4, transcript variant 1 (from RefSeq NM_001347238.2) ENSMUST00000073641.1 ENSMUST00000073641.2 ENSMUST00000073641.3 NM_001347238 Oog4 Q4G0C7 Q4G0C7_MOUSE uc008vqg.1 uc008vqg.2 uc008vqg.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vqg.1 uc008vqg.2 uc008vqg.3 
ENSMUST00000073667.6 Or1o2 ENSMUST00000073667.6 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFE1) ENSMUST00000073667.1 ENSMUST00000073667.2 ENSMUST00000073667.3 ENSMUST00000073667.4 ENSMUST00000073667.5 Olfr108 Olfr97 Or1o2 Q8VFE1 Q8VFE1_MOUSE uc289kym.1 uc289kym.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kym.1 uc289kym.2 
ENSMUST00000073674.3 Tmsb15a ENSMUST00000073674.3 thymosin beta 15a (from RefSeq NM_030106.3) ENSMUST00000073674.1 ENSMUST00000073674.2 NM_030106 Q9D2R9 Q9D2R9_MOUSE Tmsb15a uc009uhj.1 uc009uhj.2 Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Cytoplasm, cytoskeleton Belongs to the thymosin beta family. actin binding actin monomer binding cytoplasm cytoskeleton actin filament organization regulation of cell migration sequestering of actin monomers uc009uhj.1 uc009uhj.2 
ENSMUST00000073691.5 Lima1 ENSMUST00000073691.5 LIM domain and actin binding 1, transcript variant 3 (from RefSeq NR_177985.1) D15Ertd366e ENSMUST00000073691.1 ENSMUST00000073691.2 ENSMUST00000073691.3 ENSMUST00000073691.4 Eplin LIMA1_MOUSE NR_177985 Q8K2H0 Q9ERG0 Q9ERG1 uc007xqi.1 uc007xqi.2 uc007xqi.3 uc007xqi.4 Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (PubMed:29880681). Interacts with NPC1L1; bridges NPC1L1 with MYO5B (PubMed:29880681). Interacts with MYO5B; bridges MYO5B with NPC1L1 (PubMed:29880681). Interacts with PXN; this complex stabilizes actin dynamics (By similarity). Binds to G-actin and F-actin (PubMed:17875928) (By similarity). Q9ERG0-2; P35221: CTNNA1; Xeno; NbExp=2; IntAct=EBI-15677021, EBI-701918; Q9ERG0-2; P35221-1: CTNNA1; Xeno; NbExp=2; IntAct=EBI-15677021, EBI-7053242; Cytoplasm. Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, stress fiber Cell membrane Cell projection, ruffle Note=Expressed mainly in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (PubMed:29880681). Colocalizes with PXN at focal adhesions in mesangial cells (By similarity). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (PubMed:17875928). Event=Alternative promoter usage; Named isoforms=2; Name=Beta; IsoId=Q9ERG0-1; Sequence=Displayed; Name=Alpha; IsoId=Q9ERG0-2; Sequence=VSP_003118; Highly expressed in the small intestine, including the duodenum, jejunum, and ileum. Low expression in the liver and very low expressed in the heart, spleen, lung, brain, and pancreas (PubMed:29880681). Isoform Alpha is highly expressed in embryos from day 7-11 and in adult spleen and lung. Isoform Beta expression is highest in adult kidney, testis, lung and liver, intermediate in heart, brain, spleen, skeletal muscle and low in embryos. Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C- terminal domain binds filaments more efficiently than the N-terminus (By similarity). Phosphorylation of the C-terminal region by MAPK1/MAPK3 reduces its association with F-actin and contributes to actin filament reorganization and enhances cell motility. Deficient mice display reduced dietary cholesterol absorption. stress fiber ruffle actin binding actin monomer binding protein binding cytoplasm cytosol cytoskeleton plasma membrane brush border focal adhesion lipid metabolic process steroid metabolic process cholesterol metabolic process actin cytoskeleton membrane cell migration intestinal cholesterol absorption negative regulation of actin filament depolymerization brush border membrane ruffle organization cleavage furrow cholesterol homeostasis cell projection metal ion binding actin filament binding actin filament bundle assembly uc007xqi.1 uc007xqi.2 uc007xqi.3 uc007xqi.4 
ENSMUST00000073705.12 Fam222b ENSMUST00000073705.12 family with sequence similarity 222, member B, transcript variant 1 (from RefSeq NM_145430.3) ENSMUST00000073705.1 ENSMUST00000073705.10 ENSMUST00000073705.11 ENSMUST00000073705.2 ENSMUST00000073705.3 ENSMUST00000073705.4 ENSMUST00000073705.5 ENSMUST00000073705.6 ENSMUST00000073705.7 ENSMUST00000073705.8 ENSMUST00000073705.9 F222B_MOUSE NM_145430 Q3UV50 Q6P539 Q8VD11 uc007kic.1 uc007kic.2 uc007kic.3 uc007kic.4 Belongs to the FAM222 family. molecular_function nucleoplasm biological_process uc007kic.1 uc007kic.2 uc007kic.3 uc007kic.4 
ENSMUST00000073713.8 Klk1b24 ENSMUST00000073713.8 kallikrein 1-related peptidase b24 (from RefSeq NM_010643.2) A6H6V7 ENSMUST00000073713.1 ENSMUST00000073713.2 ENSMUST00000073713.3 ENSMUST00000073713.4 ENSMUST00000073713.5 ENSMUST00000073713.6 ENSMUST00000073713.7 K1B24_MOUSE Klk-24 Klk24 NM_010643 Q61754 Q61755 Q9JM69 uc009gok.1 uc009gok.2 uc009gok.3 uc009gok.4 uc009gok.5 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC146015.1, BF540391.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Reaction=Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl- bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|- Xaa.; EC=3.4.21.35; Evidence=; Belongs to the peptidase S1 family. Kallikrein subfamily. regulation of systemic arterial blood pressure endopeptidase activity serine-type endopeptidase activity cellular_component extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides secretory granule zymogen activation macromolecular complex uc009gok.1 uc009gok.2 uc009gok.3 uc009gok.4 uc009gok.5 
ENSMUST00000073721.7 1700001J03Rik ENSMUST00000073721.7 RIKEN cDNA 1700001J03 gene, transcript variant 2 (from RefSeq NM_001418329.1) 1700001J03Rik ENSMUST00000073721.1 ENSMUST00000073721.2 ENSMUST00000073721.3 ENSMUST00000073721.4 ENSMUST00000073721.5 ENSMUST00000073721.6 NM_001418329 Q80ZR8 Q80ZR8_MOUSE uc009ana.1 uc009ana.2 uc009ana.3 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc009ana.1 uc009ana.2 uc009ana.3 
ENSMUST00000073724.7 Phf1 ENSMUST00000073724.7 PHD finger protein 1, transcript variant 3 (from RefSeq NR_126158.1) ENSMUST00000073724.1 ENSMUST00000073724.2 ENSMUST00000073724.3 ENSMUST00000073724.4 ENSMUST00000073724.5 ENSMUST00000073724.6 NR_126158 O54808 PHF1_MOUSE Plc1 Q9Z1B8 Tctex-3 Tctex3 uc008bes.1 uc008bes.2 uc008bes.3 uc008bes.4 uc008bes.5 The protein encoded by this gene belongs to the polycomb-like protein family, which is a component of polycomb repressive complex-2. This complex represses gene expression by catalyzing the trimethylation of histone H3 lysine 27 and is required for the regulation of developmental genes including homeotic genes. The gene is expressed primarily in testis tissue. Small interfering RNA-mediated knockdown in cultured cell lines results in changes in homeotic gene expression coincident with alterations in promoter methylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18086877). According to other reports, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. Associated component of the PRC2 complex. Interacts with p53/TP53 (By similarity). Interacts with CHMP1. Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes specifically to the promoters of numerous target genes. Localizes to double-strand breaks (DSBs) sites following DNA damage. Colocalizes with NEK6 in the centrosome (By similarity). Testis-specific. The Tudor domain recognizes and binds H3K36me3. Belongs to the Polycomblike family. chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm centrosome microtubule organizing center cytoskeleton chromatin organization cellular response to DNA damage stimulus regulation of histone methylation methylated histone binding ESC/E(Z) complex site of double-strand break sequence-specific DNA binding positive regulation of transcription, DNA-templated metal ion binding negative regulation of histone H3-K27 methylation positive regulation of histone H3-K27 methylation nucleosome binding uc008bes.1 uc008bes.2 uc008bes.3 uc008bes.4 uc008bes.5 
ENSMUST00000073772.5 Ugt1a9 ENSMUST00000073772.5 UDP glucuronosyltransferase 1 family, polypeptide A9 (from RefSeq NM_201644.2) A6H6W3 E9QN27 ENSMUST00000073772.1 ENSMUST00000073772.2 ENSMUST00000073772.3 ENSMUST00000073772.4 NM_201644 Q62452 Q6XL44 UD19_MOUSE Ugt1 Ugt1a12 Ugt1a9 uc007byb.1 uc007byb.2 uc007byb.3 UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Also metabolizes mycophenolic acid, an immunosuppressive agent. Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21033; Evidence=; Reaction=2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53004, ChEBI:CHEBI:15378, ChEBI:CHEBI:28744, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136931; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53005; Evidence=; Reaction=4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta- estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53040, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:62845, ChEBI:CHEBI:136937; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53041; Evidence=; Reaction=2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53048, ChEBI:CHEBI:1156, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136967; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53049; Evidence=; Reaction=4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O- (beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53060, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:87602, ChEBI:CHEBI:136970; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53061; Evidence=; Reaction=prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D- glucuronide + UDP; Xref=Rhea:RHEA:63612, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:147403, ChEBI:CHEBI:147405; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63613; Evidence=; Reaction=candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP; Xref=Rhea:RHEA:63724, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:149509, ChEBI:CHEBI:149522; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63725; Evidence=; Reaction=SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP; Xref=Rhea:RHEA:63696, ChEBI:CHEBI:8988, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:149482; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63697; Evidence=; Reaction=mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP; Xref=Rhea:RHEA:63704, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:62932, ChEBI:CHEBI:149486; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63705; Evidence=; Homodimer. Homooligomer. Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10 to form heterodimers. Endoplasmic reticulum membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=1; Comment=UGT1A9 is one of the isoforms produced at the UGT1A complex locus. The UGT1A complex locus produces different isoforms based on alternative use of promoters, first exons and terminal exons. ; Name=1; IsoId=Q62452-1; Sequence=Displayed; Highly expressed in liver and at lower levels in stomach and kidney. Belongs to the UDP-glycosyltransferase family. Sequence=AAA40524.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; enzyme inhibitor activity protein kinase C binding steroid binding fatty acid binding endoplasmic reticulum endoplasmic reticulum membrane drug binding glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups enzyme binding protein homodimerization activity negative regulation of catalytic activity intracellular membrane-bounded organelle protein heterodimerization activity flavonoid glucuronidation xenobiotic glucuronidation uc007byb.1 uc007byb.2 uc007byb.3 
ENSMUST00000073781.12 E2f7 ENSMUST00000073781.12 E2F transcription factor 7, transcript variant 1 (from RefSeq NM_178609.6) B2RWZ8 E2F7_MOUSE ENSMUST00000073781.1 ENSMUST00000073781.10 ENSMUST00000073781.11 ENSMUST00000073781.2 ENSMUST00000073781.3 ENSMUST00000073781.4 ENSMUST00000073781.5 ENSMUST00000073781.6 ENSMUST00000073781.7 ENSMUST00000073781.8 ENSMUST00000073781.9 NM_178609 Q6S7F2 Q8BRE2 Q8BSQ3 Q8C9R3 uc007gzp.1 uc007gzp.2 uc007gzp.3 Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. Interacts with HIF1A (By similarity). Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA-binding. Interacts with MN1 (By similarity). Q6S7F2; Q16665: HIF1A; Xeno; NbExp=3; IntAct=EBI-8030813, EBI-447269; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6S7F2-1; Sequence=Displayed; Name=2; IsoId=Q6S7F2-2; Sequence=VSP_044618, VSP_044619; Widely expressed with highest levels in skin and thymus and very low levels in brain, muscle and stomach. Expressed in trophoblast giant cells throughout placenta development (at protein level). Highly expressed during mid to late S-phase. Induced at the onset of hepatocyte polyploidization. In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (PubMed:12893818). No visible phenotype; mice develop normally and live to old age. E2f7 and E2f8 double knockout embryos die by 11.5 dpc of massive apoptosis and dilation of blood vessels and show increased expression of E2f1 and Tp53, as well as many stress-related genes. Belongs to the E2F/DP family. Sequence=BAC32193.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding placenta development sprouting angiogenesis DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus transcription factor complex regulation of transcription, DNA-templated cellular response to DNA damage stimulus cell cycle transcription factor binding negative regulation of cell proliferation nuclear speck DNA damage response, signal transduction by p53 class mediator negative regulation of cytokinesis positive regulation of DNA endoreduplication identical protein binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter regulation of cell cycle trophoblast giant cell differentiation chorionic trophoblast cell differentiation hepatocyte differentiation negative regulation of transcription involved in G1/S transition of mitotic cell cycle RNA polymerase II transcription factor complex negative regulation of G1/S transition of mitotic cell cycle uc007gzp.1 uc007gzp.2 uc007gzp.3 
ENSMUST00000073782.4 Zfp937 ENSMUST00000073782.4 zinc finger protein 937 (from RefSeq NM_001142411.2) A2ANU7 A2ANU7_MOUSE ENSMUST00000073782.1 ENSMUST00000073782.2 ENSMUST00000073782.3 Gm4979 NM_001142411 ZIPO-I Zfp937 uc012cfs.1 uc012cfs.2 uc012cfs.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc012cfs.1 uc012cfs.2 uc012cfs.3 
ENSMUST00000073787.7 Akr7a5 ENSMUST00000073787.7 aldo-keto reductase family 7, member A5 (from RefSeq NM_025337.3) A2AMV3 ARK72_MOUSE Afar Akr7a2 Akr7a5 ENSMUST00000073787.1 ENSMUST00000073787.2 ENSMUST00000073787.3 ENSMUST00000073787.4 ENSMUST00000073787.5 ENSMUST00000073787.6 NM_025337 Q3UPU2 Q8CG76 Q8CG77 Q8JZQ8 Q9D157 uc008vmc.1 uc008vmc.2 uc008vmc.3 uc008vmc.4 Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity). Reaction=4-hydroxybutanoate + NADP(+) = H(+) + NADPH + succinate semialdehyde; Xref=Rhea:RHEA:26381, ChEBI:CHEBI:15378, ChEBI:CHEBI:16724, ChEBI:CHEBI:57706, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.n11; Evidence=; Inhibited by citrate, succinate and tartrate. Kinetic parameters: KM=19.8 uM for succinic semialdehyde ; Homodimer. Mitochondrion Golgi apparatus Cytoplasm Expressed in liver, kidney, testis and brain with low levels in skeletal muscle, spleen, heart and lung. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. Sequence=AAH31857.1; Type=Erroneous initiation; Evidence=; Sequence=CAC81077.1; Type=Erroneous initiation; Evidence=; Sequence=CAC81078.1; Type=Erroneous initiation; Evidence=; alditol:NADP+ 1-oxidoreductase activity nuclear envelope cytoplasm mitochondrion Golgi apparatus cytosol oxidoreductase activity phenanthrene-9,10-epoxide hydrolase activity daunorubicin metabolic process doxorubicin metabolic process oxidation-reduction process uc008vmc.1 uc008vmc.2 uc008vmc.3 uc008vmc.4 
ENSMUST00000073791.10 Atp5pd ENSMUST00000073791.10 ATP synthase peripheral stalk subunit d, transcript variant 5 (from RefSeq NR_184656.1) ATP5H_MOUSE Atp5h Atp5pd B1ASE1 ENSMUST00000073791.1 ENSMUST00000073791.2 ENSMUST00000073791.3 ENSMUST00000073791.4 ENSMUST00000073791.5 ENSMUST00000073791.6 ENSMUST00000073791.7 ENSMUST00000073791.8 ENSMUST00000073791.9 NR_184656 Q542H1 Q7M0I0 Q91YK9 Q9DCX2 uc288dky.1 uc288dky.2 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding (PubMed:32973183). Mitochondrion. Mitochondrion inner membrane. Belongs to the ATPase d subunit family. mitochondrial proton-transporting ATP synthase, stator stalk mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) nucleoplasm mitochondrion mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex ion transport hydrogen ion transmembrane transporter activity ATP synthesis coupled proton transport membrane ATPase activity myelin sheath macromolecular complex binding proton-transporting ATP synthase complex, coupling factor F(o) ATP metabolic process cellular response to peptide proton-transporting ATP synthase activity, rotational mechanism uc288dky.1 uc288dky.2 
ENSMUST00000073822.6 Opcml ENSMUST00000073822.6 Cell membrane ; Lipid-anchor, GPI-anchor Membrane ; Lipid-anchor, GPI-anchor (from UniProt G5E8G3) BC076581 ENSMUST00000073822.1 ENSMUST00000073822.2 ENSMUST00000073822.3 ENSMUST00000073822.4 ENSMUST00000073822.5 G5E8G3 G5E8G3_MOUSE Opcml uc292fkl.1 uc292fkl.2 Cell membrane ; Lipid-anchor, GPI-anchor Membrane ; Lipid-anchor, GPI-anchor Belongs to the immunoglobulin superfamily. IgLON family. molecular_function uc292fkl.1 uc292fkl.2 
ENSMUST00000073834.5 Lrrc10 ENSMUST00000073834.5 leucine rich repeat containing 10 (from RefSeq NM_146242.2) ENSMUST00000073834.1 ENSMUST00000073834.2 ENSMUST00000073834.3 ENSMUST00000073834.4 Hrlrrp LRC10_MOUSE NM_146242 Q8BUL2 Q8K3W2 uc007hcr.1 uc007hcr.2 May play important roles in cardiac development and/or cardiac function. Nucleus Detected specifically in the heart. actin binding nucleus mitochondrion cytoskeleton myofibril sarcomere alpha-actinin binding cardiac muscle cell development uc007hcr.1 uc007hcr.2 
ENSMUST00000073837.13 Pou6f1 ENSMUST00000073837.13 POU domain, class 6, transcription factor 1, transcript variant 2 (from RefSeq NM_001404294.1) ENSMUST00000073837.1 ENSMUST00000073837.10 ENSMUST00000073837.11 ENSMUST00000073837.12 ENSMUST00000073837.2 ENSMUST00000073837.3 ENSMUST00000073837.4 ENSMUST00000073837.5 ENSMUST00000073837.6 ENSMUST00000073837.7 ENSMUST00000073837.8 ENSMUST00000073837.9 NM_001404294 Pou6f1 Q5U4D4 Q5U4D4_MOUSE uc007xrr.1 uc007xrr.2 Nucleus Belongs to the POU transcription factor family. RNA polymerase II regulatory region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated actin cytoskeleton nuclear body uc007xrr.1 uc007xrr.2 
ENSMUST00000073853.3 Krtap2-20 ENSMUST00000073853.3 predicted gene 11562 (from RefSeq NM_001177537.2) A0PK51 A0PK51_MOUSE ENSMUST00000073853.1 ENSMUST00000073853.2 Gm11562 Krtap2-4 NM_001177537 OTTMUSG00000002199 uc029roa.1 uc029roa.2 uc029roa.3 molecular_function cellular_component intermediate filament biological_process keratin filament uc029roa.1 uc029roa.2 uc029roa.3 
ENSMUST00000073857.6 Tgif2lx1 ENSMUST00000073857.6 TGFB-induced factor homeobox 2-like, X-linked 1 (from RefSeq NM_153109.1) ENSMUST00000073857.1 ENSMUST00000073857.2 ENSMUST00000073857.3 ENSMUST00000073857.4 ENSMUST00000073857.5 NM_153109 Q8K5B9 Q8K5B9_MOUSE Tgif2lx1 Tgif2lx2 uc009uec.1 uc009uec.2 uc009uec.3 uc009uec.4 uc009uec.5 Nucleus Belongs to the TALE/TGIF homeobox family. molecular_function DNA binding cellular_component nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding uc009uec.1 uc009uec.2 uc009uec.3 uc009uec.4 uc009uec.5 
ENSMUST00000073860.6 Ang4 ENSMUST00000073860.6 angiogenin, ribonuclease A family, member 4 (from RefSeq NM_177544.4) Ang4 ENSMUST00000073860.1 ENSMUST00000073860.2 ENSMUST00000073860.3 ENSMUST00000073860.4 ENSMUST00000073860.5 NM_177544 Raa4 W0UUX7 W0UUX7_MOUSE uc007tnd.1 uc007tnd.2 uc007tnd.3 Cytoplasmic vesicle, secretory vesicle lumen Nucleus, nucleolus Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity hydrolase activity nucleic acid phosphodiester bond hydrolysis uc007tnd.1 uc007tnd.2 uc007tnd.3 
ENSMUST00000073868.9 Naca ENSMUST00000073868.9 nascent polypeptide-associated complex alpha polypeptide, transcript variant 2 (from RefSeq NM_013608.3) ENSMUST00000073868.1 ENSMUST00000073868.2 ENSMUST00000073868.3 ENSMUST00000073868.4 ENSMUST00000073868.5 ENSMUST00000073868.6 ENSMUST00000073868.7 ENSMUST00000073868.8 NACA_MOUSE NM_013608 Q3THR6 Q4FZL8 Q60817 uc007hlb.1 uc007hlb.2 uc007hlb.3 uc007hlb.4 Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). Isoform 1 and isoform 2 appear to bind DNA and play roles in transcription. Isoform 1 may function as a specific coactivator for JUN, acting to stabilize the interaction of JUN homodimers with promoter elements. Part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of NACA and BTF3 (via NAC-A/B domains). NAC associates with ribosomes through the BTF3/NACB subunit and contacts the ribosomal protein L23, which is positioned near the exiting site. Both subunits can contact nascent polypeptide chains. NACA may also form homodimers, and only this form binds DNA (By similarity). Interacts with TBP and JUN. Cytoplasm. Nucleus. Note=The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60817-1; Sequence=Displayed; Name=2; Synonyms=Gp220, skNAC; IsoId=P70670-1; Sequence=External; Isoform 1 appears to be ubiquitously expressed. Expressed concomitant with the onset of mineralization in ossification centers of developing bone. The positively charged inner surface of the NAC-A/B domain is crucial for NACA localization in the nucleus and DNA-binding. This region is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit, it also displays much higher affinity for RNA than DNA (By similarity). Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation. Belongs to the NAC-alpha family. cardiac ventricle development DNA binding transcription coactivator activity nucleus cytoplasm nascent polypeptide-associated complex negative regulation of striated muscle cell apoptotic process protein transport TBP-class protein binding skeletal muscle tissue regeneration positive regulation of skeletal muscle tissue growth regulation of skeletal muscle fiber development myoblast migration heart trabecula morphogenesis negative regulation of transcription from RNA polymerase II promoter involved in heart development positive regulation of transcription from RNA polymerase II promoter involved in heart development positive regulation of cell proliferation involved in heart morphogenesis uc007hlb.1 uc007hlb.2 uc007hlb.3 uc007hlb.4 
ENSMUST00000073870.7 Dusp29 ENSMUST00000073870.7 dual specificity phosphatase 29, transcript variant 2 (from RefSeq NM_001418869.1) B2RW26 DUS29_MOUSE Dupd1 Dusp27 Dusp29 ENSMUST00000073870.1 ENSMUST00000073870.2 ENSMUST00000073870.3 ENSMUST00000073870.4 ENSMUST00000073870.5 ENSMUST00000073870.6 NM_001418869 Q8BK84 uc007sll.1 uc007sll.2 uc007sll.3 Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of intracellular signaling cascades. In skeletal muscle regulates systemic glucose homeostasis by activating, AMPK, an energy sensor protein kinase (PubMed:30201684). Affects MAP kinase signaling though modulation of the MAPK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (PubMed:32639872). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Homodimer (By similarity). Interacts with PRKAA2 (PubMed:30201684). Cytoplasm cleus Skeletal muscle, liver and adipose tissue. Up-regulated during muscle cell differentiation. Deletion of the long non-coding RNA (lncRNA) H19 leads to a decreased DUSP29 expression in muscle (at protein level). Down- regulated in muscle of high-fat diets-induced glucose-intolerant mice (PubMed:30201684). Induced during neurogenic skeletal muscle atrophy (PubMed:32639872). Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytoplasm protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity macromolecular complex peptidyl-tyrosine dephosphorylation protein homodimerization activity uc007sll.1 uc007sll.2 uc007sll.3 
ENSMUST00000073878.12 Dhcr7 ENSMUST00000073878.12 7-dehydrocholesterol reductase, transcript variant 1 (from RefSeq NM_007856.2) DHCR7_MOUSE ENSMUST00000073878.1 ENSMUST00000073878.10 ENSMUST00000073878.11 ENSMUST00000073878.2 ENSMUST00000073878.3 ENSMUST00000073878.4 ENSMUST00000073878.5 ENSMUST00000073878.6 ENSMUST00000073878.7 ENSMUST00000073878.8 ENSMUST00000073878.9 NM_007856 O88455 uc009kqc.1 uc009kqc.2 uc009kqc.3 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7- dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien- 3beta-ol, two intermediates in that pathway. Reaction=cholesterol + NADP(+) = 7-dehydrocholesterol + H(+) + NADPH; Xref=Rhea:RHEA:23984, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:17759, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.21; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:23986; Evidence=; Reaction=7-dehydrodesmosterol + H(+) + NADPH = desmosterol + NADP(+); Xref=Rhea:RHEA:46740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17737, ChEBI:CHEBI:27910, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46741; Evidence=; Steroid biosynthesis; cholesterol biosynthesis. Interacts with DHCR24; this interaction regulates DHCR7 activity. Interacts with TMEM147. Endoplasmic reticulum membrane ; Multi-pass membrane protein Deficient mice die within one day of birth due to respiratory and suckling problems. They exhibit abnormal cholesterol homeostasis with reduced tissue cholesterol levels and total sterol levels, enlarged bladders and sometimes cleft palate. Belongs to the ERG4/ERG24 family. blood vessel development nuclear outer membrane endoplasmic reticulum endoplasmic reticulum membrane cytosol lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process steroid metabolic process cholesterol metabolic process post-embryonic development sterol delta7 reductase activity membrane integral component of membrane sterol biosynthetic process brassinosteroid biosynthetic process oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor cell differentiation integral component of endoplasmic reticulum membrane lung development multicellular organism growth regulation of cell proliferation intracellular membrane-bounded organelle regulation of cholesterol biosynthetic process 7-dehydrocholesterol reductase activity NADP binding oxidation-reduction process uc009kqc.1 uc009kqc.2 uc009kqc.3 
ENSMUST00000073889.14 Polg ENSMUST00000073889.14 polymerase (DNA directed), gamma, transcript variant 1 (from RefSeq NM_017462.3) ENSMUST00000073889.1 ENSMUST00000073889.10 ENSMUST00000073889.11 ENSMUST00000073889.12 ENSMUST00000073889.13 ENSMUST00000073889.2 ENSMUST00000073889.3 ENSMUST00000073889.4 ENSMUST00000073889.5 ENSMUST00000073889.6 ENSMUST00000073889.7 ENSMUST00000073889.8 ENSMUST00000073889.9 NM_017462 Polg Q75WC0 Q75WC0_MOUSE uc009hyj.1 uc009hyj.2 uc009hyj.3 Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA. Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits. Mitochondrion matrix, mitochondrion nucleoid Belongs to the DNA polymerase type-A family. protease binding DNA binding chromatin binding DNA-directed DNA polymerase activity mitochondrion gamma DNA polymerase complex DNA replication base-excision repair, gap-filling aging response to light stimulus response to gamma radiation macromolecular complex mitochondrial nucleoid terminal bouton response to hyperoxia cellular response to glucose stimulus DNA biosynthetic process uc009hyj.1 uc009hyj.2 uc009hyj.3 
ENSMUST00000073890.4 Krt33b ENSMUST00000073890.4 keratin 33B (from RefSeq NM_013570.1) A2A5X8 ENSMUST00000073890.1 ENSMUST00000073890.2 ENSMUST00000073890.3 Hka3 KT33B_MOUSE Krt1-3 NM_013570 Q61897 uc007lkb.1 uc007lkb.2 uc007lkb.3 Expressed strongly in cortex cells in newborn back skin and in the central unit of the lingual filiform papillae. There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). Belongs to the intermediate filament family. structural molecule activity intermediate filament uc007lkb.1 uc007lkb.2 uc007lkb.3 
ENSMUST00000073895.4 Or8g33 ENSMUST00000073895.4 olfactory receptor family 8 subfamily G member 33 (from RefSeq NM_146503.2) ENSMUST00000073895.1 ENSMUST00000073895.2 ENSMUST00000073895.3 NM_146503 Olfr952 Or8g33 Q8VFD7 Q8VFD7_MOUSE uc009oxx.1 uc009oxx.2 uc009oxx.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC150723.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oxx.1 uc009oxx.2 uc009oxx.3 
ENSMUST00000073909.6 Dcp1b ENSMUST00000073909.6 May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). (from UniProt Q3U564) AK050548 B2RUI2 DCP1B_MOUSE ENSMUST00000073909.1 ENSMUST00000073909.2 ENSMUST00000073909.3 ENSMUST00000073909.4 ENSMUST00000073909.5 Q3U564 Q3V333 uc009dly.1 uc009dly.2 uc009dly.3 uc009dly.4 May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP; Xref=Rhea:RHEA:67484, Rhea:RHEA-COMP:15692, Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:63714, ChEBI:CHEBI:138282, ChEBI:CHEBI:156461; EC=3.6.1.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67485; Evidence=; Interacts with DCP1A. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U564-1; Sequence=Displayed; Name=2; IsoId=Q3U564-2; Sequence=VSP_025609; Belongs to the DCP1 family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay deadenylation-dependent decapping of nuclear-transcribed mRNA P-body nucleus cytoplasm cytosol enzyme activator activity hydrolase activity deadenylation-independent decapping of nuclear-transcribed mRNA positive regulation of catalytic activity intracellular membrane-bounded organelle uc009dly.1 uc009dly.2 uc009dly.3 uc009dly.4 
ENSMUST00000073924.10 2810021J22Rik ENSMUST00000073924.10 RIKEN cDNA 2810021J22 gene (from RefSeq NM_172403.2) 2810021J22Rik ENSMUST00000073924.1 ENSMUST00000073924.2 ENSMUST00000073924.3 ENSMUST00000073924.4 ENSMUST00000073924.5 ENSMUST00000073924.6 ENSMUST00000073924.7 ENSMUST00000073924.8 ENSMUST00000073924.9 NM_172403 Q8BIB6 Q8BIB6_MOUSE uc007jcm.1 uc007jcm.2 uc007jcm.3 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc007jcm.1 uc007jcm.2 uc007jcm.3 
ENSMUST00000073935.7 Gsg1l ENSMUST00000073935.7 GSG1-like, transcript variant 4 (from RefSeq NM_001419660.1) D3Z7H4 ENSMUST00000073935.1 ENSMUST00000073935.2 ENSMUST00000073935.3 ENSMUST00000073935.4 ENSMUST00000073935.5 ENSMUST00000073935.6 GSG1L_MOUSE NM_001419660 uc009jqp.1 uc009jqp.2 uc009jqp.3 uc009jqp.4 As a component of the inner core of AMPAR complexes, modifies AMPA receptor (AMPAR) gating. Component of the inner core of AMPAR complexes. AMPAR complexes consist of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complexes is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complexes and profoundly impact their biogenesis and protein processing. Cell membrane ; Multi-pass membrane protein Synapse Expressed in the brain, including hippocampus (at protein level). Belongs to the GSG1 family. molecular_function plasma membrane postsynaptic density membrane integral component of membrane cell junction asymmetric synapse synapse glutamatergic synapse integral component of postsynaptic density membrane regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc009jqp.1 uc009jqp.2 uc009jqp.3 uc009jqp.4 
ENSMUST00000073942.12 Cnbd2 ENSMUST00000073942.12 cyclic nucleotide binding domain containing 2, transcript variant 2 (from RefSeq NM_001316755.1) 4921517L17Rik A2AV95 A2AV95_MOUSE Cnbd2 ENSMUST00000073942.1 ENSMUST00000073942.10 ENSMUST00000073942.11 ENSMUST00000073942.2 ENSMUST00000073942.3 ENSMUST00000073942.4 ENSMUST00000073942.5 ENSMUST00000073942.6 ENSMUST00000073942.7 ENSMUST00000073942.8 ENSMUST00000073942.9 NM_001316755 uc290bxk.1 uc290bxk.2 uc290bxk.1 uc290bxk.2 
ENSMUST00000073948.7 Vmn2r19 ENSMUST00000073948.7 vomeronasal 2, receptor 19 (from RefSeq NM_001104632.1) ENSMUST00000073948.1 ENSMUST00000073948.2 ENSMUST00000073948.3 ENSMUST00000073948.4 ENSMUST00000073948.5 ENSMUST00000073948.6 G5E8G4 G5E8G4_MOUSE NM_001104632 Vmn2r19 uc009vdu.1 uc009vdu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vdu.1 uc009vdu.2 
ENSMUST00000073949.4 H2al1m ENSMUST00000073949.4 H2A histone family member L1M (from RefSeq NM_029588.3) 1700012L04Rik B1AV31 ENSMUST00000073949.1 ENSMUST00000073949.2 ENSMUST00000073949.3 H2al1m NM_029588 Q9DAD9 Q9DAD9_MOUSE uc009spr.1 uc009spr.2 uc009spr.3 The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc009spr.1 uc009spr.2 uc009spr.3 
ENSMUST00000073957.8 Sema3e ENSMUST00000073957.8 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E (from RefSeq NM_011348.2) ENSMUST00000073957.1 ENSMUST00000073957.2 ENSMUST00000073957.3 ENSMUST00000073957.4 ENSMUST00000073957.5 ENSMUST00000073957.6 ENSMUST00000073957.7 NM_011348 O09078 O09079 P70275 Q9QX23 SEM3E_MOUSE Semah Semh uc008wme.1 uc008wme.2 Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation. Interacts with PLXND1. P70275; Q9Y4D7: PLXND1; Xeno; NbExp=2; IntAct=EBI-8876322, EBI-310731; Secreted. Detected in neurons in the thalamus. Detected in embryonic vasculature. Developing lungs, developing skeletal elements and ventral horns of the developing neural tube. Correlates positively with tumor progression. Embryos present defects in the patterning of intersomitic vasculature. Belongs to the semaphorin family. angiogenesis branching involved in blood vessel morphogenesis neural crest cell migration negative regulation of cell-matrix adhesion sprouting angiogenesis protein binding extracellular region extracellular space integral component of plasma membrane multicellular organism development nervous system development regulation of cell shape negative regulation of angiogenesis cell differentiation semaphorin receptor binding positive regulation of cell migration chemorepellent activity negative regulation of axon extension involved in axon guidance synapse organization negative chemotaxis semaphorin-plexin signaling pathway regulation of actin cytoskeleton reorganization uc008wme.1 uc008wme.2 
ENSMUST00000073962.8 Fbxw24 ENSMUST00000073962.8 F-box and WD-40 domain protein 24 (from RefSeq NM_001013776.4) E9PXM9 E9PXM9_MOUSE ENSMUST00000073962.1 ENSMUST00000073962.2 ENSMUST00000073962.3 ENSMUST00000073962.4 ENSMUST00000073962.5 ENSMUST00000073962.6 ENSMUST00000073962.7 Fbxw24 NM_001013776 uc009rsm.1 uc009rsm.2 uc009rsm.3 uc009rsm.4 uc009rsm.5 molecular_function cellular_component biological_process uc009rsm.1 uc009rsm.2 uc009rsm.3 uc009rsm.4 uc009rsm.5 
ENSMUST00000073967.4 Vmn1r177 ENSMUST00000073967.4 vomeronasal 1 receptor 177 (from RefSeq NM_206872.2) E9PXM3 E9PXM3_MOUSE ENSMUST00000073967.1 ENSMUST00000073967.2 ENSMUST00000073967.3 NM_206872 Vmn1r177 uc009fok.1 uc009fok.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009fok.1 uc009fok.2 
ENSMUST00000074002.12 Ube3b ENSMUST00000074002.12 ubiquitin protein ligase E3B, transcript variant 3 (from RefSeq NR_138602.2) ENSMUST00000074002.1 ENSMUST00000074002.10 ENSMUST00000074002.11 ENSMUST00000074002.2 ENSMUST00000074002.3 ENSMUST00000074002.4 ENSMUST00000074002.5 ENSMUST00000074002.6 ENSMUST00000074002.7 ENSMUST00000074002.8 ENSMUST00000074002.9 NR_138602 Q8K068 Q9ES34 UBE3B_MOUSE uc008yzn.1 uc008yzn.2 uc008yzn.3 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Protein modification; protein ubiquitination. Widely expressed. High expression is observed in developing central nervous system. Sequence=AAH34059.1; Type=Erroneous initiation; Evidence=; protein polyubiquitination ubiquitin-protein transferase activity ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity ubiquitin conjugating enzyme activity uc008yzn.1 uc008yzn.2 uc008yzn.3 
ENSMUST00000074015.11 Negr1 ENSMUST00000074015.11 neuronal growth regulator 1, transcript variant 1 (from RefSeq NM_001039094.3) ENSMUST00000074015.1 ENSMUST00000074015.10 ENSMUST00000074015.2 ENSMUST00000074015.3 ENSMUST00000074015.4 ENSMUST00000074015.5 ENSMUST00000074015.6 ENSMUST00000074015.7 ENSMUST00000074015.8 ENSMUST00000074015.9 Kiaa3001 NEGR1_MOUSE NM_001039094 Ntra Q3UHQ8 Q80T70 Q80Z24 uc008rvc.1 uc008rvc.2 uc008rvc.3 uc008rvc.4 May be involved in cell-adhesion. May function as a trans- neural growth-promoting factor in regenerative axon sprouting in the mammalian brain. Cell membrane ; Lipid-anchor, GPI- anchor Expressed in brain. Belongs to the immunoglobulin superfamily. IgLON family. molecular_function plasma membrane cell adhesion locomotory behavior feeding behavior positive regulation of neuron projection development membrane dendrite anchored component of membrane neuronal cell body cell-cell adhesion uc008rvc.1 uc008rvc.2 uc008rvc.3 uc008rvc.4 
ENSMUST00000074018.4 Mup20 ENSMUST00000074018.4 major urinary protein 20 (from RefSeq NM_001012323.1) ENSMUST00000074018.1 ENSMUST00000074018.2 ENSMUST00000074018.3 MUP20_MOUSE Mup20 Mup24 NM_001012323 Q5FW60 uc008tbr.1 uc008tbr.2 uc008tbr.3 uc008tbr.4 Male pheromone which stimulates female sexual attraction to male urinary scent and promotes a strong learned attraction to the airborne urinary odor of an individual male (PubMed:20525243, PubMed:31996852). Promotes spatial learning by rapidly conditioning preference for its remembered location among females and competitor males so that animals prefer to spend time in the site even when scent is absent (PubMed:23239735). In addition to promoting a rapid attraction response, also elicits ultrasonic vocalizations and urinary scent marking in females which do not occur immediately after exposure (PubMed:31996852). Stimulates hippocampal neurogenesis and cell proliferation in the subventricular zone in females (PubMed:25972792). Promotes male aggressive behavior (PubMed:18064011). Response to Mup20 is mediated by a neural circuit extending from the accessory olfactory bulb to a subset of nitric oxidase synthase-expressing neurons in the medial amygdala (PubMed:31996852). As well as acting as a pheromone itself, binds most of the male pheromone, 2-sec-butyl-4,5- dihydrothiazole, in urine and is responsible for its slow release from scent marks (PubMed:15934926, PubMed:25279835). Secreted Detected in urine of males but absent from female urine (at protein level). Mass=18894; Mass_error=2; Method=Electrospray; Evidence=; Constitutes approximately 10% of the total major urinary protein composition in the urine of C57BL/6 males but is barely detectable in the urine of BALB/c males. Belongs to the calycin superfamily. Lipocalin family. mating pheromone activity insulin-activated receptor activity pheromone activity pheromone binding extracellular region extracellular space nucleus cytosol energy reserve metabolic process insulin receptor signaling pathway olfactory learning aerobic respiration positive regulation of gene expression negative regulation of lipid storage positive regulation of glucose metabolic process heat generation small molecule binding glucose homeostasis locomotor rhythm negative regulation of gluconeogenesis positive regulation of lipid metabolic process negative regulation of transcription, DNA-templated negative regulation of lipid biosynthetic process positive regulation of protein kinase B signaling negative regulation of insulin secretion involved in cellular response to glucose stimulus mitochondrion morphogenesis cellular response to lipid uc008tbr.1 uc008tbr.2 uc008tbr.3 uc008tbr.4 
ENSMUST00000074043.7 Klf10 ENSMUST00000074043.7 Kruppel-like transcription factor 10, transcript variant 1 (from RefSeq NM_013692.4) ENSMUST00000074043.1 ENSMUST00000074043.2 ENSMUST00000074043.3 ENSMUST00000074043.4 ENSMUST00000074043.5 ENSMUST00000074043.6 Gdnfif KLF10_MOUSE NM_013692 O89091 Tieg Tieg1 uc007vnr.1 uc007vnr.2 uc007vnr.3 uc007vnr.4 Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. O89091; Q8C863: Itch; NbExp=4; IntAct=EBI-10949150, EBI-851782; Nucleus By TGF-beta and GDNF. Expressed in a circadian manner in the liver with a high at ZT14-18 and a low at ZT2 (at protein level). Expressed in a circadian manner in the bone, kidney and skeletal muscle. Up-regulated in response to glucose. Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. Male mice display postprandial and fasting hyperglycemia while female mice are normoglycemic but display higher plasma triglycerides. Belongs to the Sp1 C2H2-type zinc-finger protein family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter circadian rhythm cellular response to starvation bone mineralization somatic stem cell population maintenance regulation of circadian rhythm positive regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding rhythmic process cellular response to peptide uc007vnr.1 uc007vnr.2 uc007vnr.3 uc007vnr.4 
ENSMUST00000074051.6 Serpina1c ENSMUST00000074051.6 serine (or cysteine) peptidase inhibitor, clade A, member 1C (from RefSeq NM_009245.2) A0A0R4J0X5 A0A0R4J0X5_MOUSE ENSMUST00000074051.1 ENSMUST00000074051.2 ENSMUST00000074051.3 ENSMUST00000074051.4 ENSMUST00000074051.5 NM_009245 Serpina1c uc007owk.1 uc007owk.2 uc007owk.3 Belongs to the serpin family. extracellular space uc007owk.1 uc007owk.2 uc007owk.3 
ENSMUST00000074053.6 Sap18b ENSMUST00000074053.6 Sin3-associated polypeptide 18B (from RefSeq NM_001142441.1) E9Q317 E9Q317_MOUSE ENSMUST00000074053.1 ENSMUST00000074053.2 ENSMUST00000074053.3 ENSMUST00000074053.4 ENSMUST00000074053.5 NM_001142441 Sap18 Sap18b uc033jha.1 uc033jha.2 uc033jha.3 uc033jha.4 This intronless gene is highly similar to the multi-exon Sap18 gene on chromosome 14, whose product functions in transcriptional repression as a component of the Sin3 histone deacetylase complex. This gene may possibly be a Sap18 pseudogene, but it is represented as protein-coding because it appears to be transcribed and has an intact ORF that would result in a protein that is 100% identical to the Sap18 protein. [provided by RefSeq, Dec 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Belongs to the SAP18 family. nucleoplasm cytosol biological_process nuclear body nuclear speck ASAP complex exon-exon junction complex uc033jha.1 uc033jha.2 uc033jha.3 uc033jha.4 
ENSMUST00000074056.3 Klra6 ENSMUST00000074056.3 killer cell lectin-like receptor, subfamily A, member 6 (from RefSeq NM_008464.3) ENSMUST00000074056.1 ENSMUST00000074056.2 KLRA6_MOUSE Ly-49f Ly49-f Ly49F NM_008464 Q60653 uc009ehe.1 uc009ehe.2 uc009ehe.3 This gene belongs to the highly polymorphic family of C-type lectin-like Ly49 genes that are expressed in natural killer (NK) cells. The encoded protein is a homodimeric type II transmembrane receptor located at the cell surface and inhibits NK cell activation upon ligand binding. This gene is located in a cluster of several Klra paralogs on chromosome 6. Different strains of mice show variation in the number of paralogs, including strain specific duplications, deletions and pseudogene sequences. [provided by RefSeq, Apr 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U10092.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849383 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## Receptor on natural killer (NK) cells for class I MHC. Homodimer; disulfide-linked. Membrane; Single-pass type II membrane protein. plasma membrane cell adhesion membrane integral component of membrane carbohydrate binding uc009ehe.1 uc009ehe.2 uc009ehe.3 
ENSMUST00000074058.11 Mbd2 ENSMUST00000074058.11 methyl-CpG binding domain protein 2, transcript variant 1 (from RefSeq NM_010773.2) E9QMV9 ENSMUST00000074058.1 ENSMUST00000074058.10 ENSMUST00000074058.2 ENSMUST00000074058.3 ENSMUST00000074058.4 ENSMUST00000074058.5 ENSMUST00000074058.6 ENSMUST00000074058.7 ENSMUST00000074058.8 ENSMUST00000074058.9 MBD2_MOUSE Mbd2 NM_010773 Q811D9 Q9Z2D9 Q9Z2E1 uc008fon.1 uc008fon.2 uc008fon.3 uc008fon.4 Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (By similarity). Recruits histone deacetylases and DNA methyltransferases to chromatin (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Acts as transcriptional repressor and plays a role in gene silencing (By similarity). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (By similarity). May enhance the activation of some unmethylated cAMP-responsive promoters (By similarity). Selectively represses transcription activity of methylated rRNA promoters (PubMed:14610093). Heterodimer with MBD3 (via N-terminus) (By similarity). Component of the MeCP1 complex that contains HDAC1 and HDAC2 (By similarity). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (By similarity). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (By similarity). Interacts with CDK2AP1 (By similarity). Interacts with DHX9 (By similarity). Interacts with DNMT1 (By similarity). Interacts with GATAD2A/p66-alpha (By similarity). Interacts with GATAD2B/p66-beta (By similarity). Interacts with GPN1 (By similarity). Interacts with MIZF (By similarity). Interacts with PRMT5 (By similarity). Interacts with SIN3A (By similarity). Interacts with SPHK2 (By similarity). Q9Z2E1; Q9Z2E1: Mbd2; NbExp=6; IntAct=EBI-5716946, EBI-5716946; Q9Z2E1; Q00566: Mecp2; Xeno; NbExp=9; IntAct=EBI-5716946, EBI-9396907; Nucleus Chromosome Note=Nuclear, in discrete foci. Detected at replication foci in late S phase. Localizes to methylated chromatin. Localizes to sites of DNA damage in a manner partially dependent on ZMYND8. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z2E1-1; Sequence=Displayed; Name=2; IsoId=Q9Z2E1-2; Sequence=VSP_011079, VSP_011080; Highly expressed in brain, heart, kidney, lung, skeletal muscle, spleen and testis. Detected at lower levels in embryonic stem cells. histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter chromatin nuclear chromatin heterochromatin DNA binding chromatin binding mRNA binding protein binding nucleus nucleoplasm cytoplasm cytosol methylation-dependent chromatin silencing heart development aging methyl-CpG binding response to mechanical stimulus response to organic cyclic compound protein domain specific binding positive regulation of Wnt signaling pathway response to nutrient levels response to estradiol cellular macromolecular complex assembly siRNA binding positive regulation of chromatin binding regulation of cell proliferation maternal behavior regulation of DNA methylation embryonic organ development C2H2 zinc finger domain binding cellular response to organic cyclic compound nucleolus uc008fon.1 uc008fon.2 uc008fon.3 uc008fon.4 
ENSMUST00000074064.5 Or51a42 ENSMUST00000074064.5 olfactory receptor family 51 subfamily A member 42 (from RefSeq NM_147077.1) 4930516K23Rik ENSMUST00000074064.1 ENSMUST00000074064.2 ENSMUST00000074064.3 ENSMUST00000074064.4 NM_147077 Olfr643 Or51a42 Q8VGY1 Q8VGY1_MOUSE uc291tsu.1 uc291tsu.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC106803.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tsu.1 uc291tsu.2 
ENSMUST00000074072.5 Rps18-ps6 ENSMUST00000074072.5 Component of the small ribosomal subunit. (from UniProt F6YVP7) AK146354 ENSMUST00000074072.1 ENSMUST00000074072.2 ENSMUST00000074072.3 ENSMUST00000074072.4 F6YVP7 F6YVP7_MOUSE Gm10260 Gm17352 Rps18-ps6 uc288pjn.1 uc288pjn.2 Component of the small ribosomal subunit. Cytoplasm Belongs to the universal ribosomal protein uS13 family. nucleic acid binding RNA binding structural constituent of ribosome cytosol ribosome translation uc288pjn.1 uc288pjn.2 
ENSMUST00000074077.12 Bmp4 ENSMUST00000074077.12 bone morphogenetic protein 4, transcript variant 1 (from RefSeq NM_007554.3) Bmp4 ENSMUST00000074077.1 ENSMUST00000074077.10 ENSMUST00000074077.11 ENSMUST00000074077.2 ENSMUST00000074077.3 ENSMUST00000074077.4 ENSMUST00000074077.5 ENSMUST00000074077.6 ENSMUST00000074077.7 ENSMUST00000074077.8 ENSMUST00000074077.9 NM_007554 Q3ULR1 Q3ULR1_MOUSE uc007thd.1 uc007thd.2 uc007thd.3 uc007thd.4 uc007thd.5 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016]. Belongs to the TGF-beta family. negative regulation of transcription from RNA polymerase II promoter activation of MAPKK activity osteoblast differentiation ureteric bud development branching involved in ureteric bud morphogenesis kidney development mesonephros development positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation blood vessel endothelial cell proliferation involved in sprouting angiogenesis hematopoietic progenitor cell differentiation lymphoid progenitor cell differentiation BMP signaling pathway involved in heart induction secondary heart field specification type B pancreatic cell development mesenchymal to epithelial transition involved in metanephros morphogenesis cytokine activity extracellular region extracellular space common-partner SMAD protein phosphorylation smoothened signaling pathway growth factor activity positive regulation of cell proliferation negative regulation of cell proliferation post-embryonic development regulation of cell fate commitment positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of cell death telencephalon development monocyte differentiation macrophage differentiation positive regulation of bone mineralization BMP signaling pathway positive regulation of protein binding positive regulation of collagen biosynthetic process negative regulation of T cell differentiation in thymus negative regulation of immature T cell proliferation in thymus protein localization to nucleus co-receptor binding chemoattractant activity regulation of protein import into nucleus negative regulation of phosphorylation odontogenesis positive regulation of apoptotic process negative regulation of apoptotic process steroid hormone mediated signaling pathway negative regulation of MAP kinase activity positive regulation of epidermal cell differentiation negative regulation of myoblast differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of cell cycle negative regulation of mitotic nuclear division negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lung alveolus development intermediate mesodermal cell differentiation positive regulation of smooth muscle cell proliferation branching morphogenesis of an epithelial tube positive regulation of epithelial cell proliferation positive chemotaxis positive regulation of cardiac muscle fiber development positive regulation of SMAD protein import into nucleus regulation of pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction lung morphogenesis bronchus development trachea development epithelial tube branching involved in lung morphogenesis epithelial cell proliferation involved in lung morphogenesis bud dilation involved in lung branching negative regulation of cell death positive regulation of cartilage development pulmonary artery endothelial tube morphogenesis negative regulation of thymocyte apoptotic process BMP receptor binding cellular response to BMP stimulus BMP signaling pathway involved in nephric duct formation renal system development negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway negative regulation of glomerular mesangial cell proliferation negative regulation of mesenchymal cell proliferation involved in ureter development positive regulation of kidney development negative regulation of branching involved in ureteric bud morphogenesis negative regulation of glomerulus development negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of production of miRNAs involved in gene silencing by miRNA negative regulation of metanephric S-shaped body morphogenesis negative regulation of metanephric comma-shaped body morphogenesis negative regulation of cell proliferation involved in heart morphogenesis uc007thd.1 uc007thd.2 uc007thd.3 uc007thd.4 uc007thd.5 
ENSMUST00000074103.12 Pde4d ENSMUST00000074103.12 phosphodiesterase 4D, cAMP specific, transcript variant 5 (from RefSeq NM_001402886.1) B2KF58 ENSMUST00000074103.1 ENSMUST00000074103.10 ENSMUST00000074103.11 ENSMUST00000074103.2 ENSMUST00000074103.3 ENSMUST00000074103.4 ENSMUST00000074103.5 ENSMUST00000074103.6 ENSMUST00000074103.7 ENSMUST00000074103.8 ENSMUST00000074103.9 NM_001402886 PDE4D_MOUSE Q01063 Q6TRH9 Q8C4Q7 Q8CG05 uc288pwf.1 uc288pwf.2 Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions. ; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 2 has a preference for magnesium and/or manganese ions. ; Inhibited by rolipram. Activated by phosphatidic acid (By similarity). Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. Homodimer for the long isoforms. Isoforms with truncated N- termini are monomeric. Binds ARRB2. Interacts with PDE4DIP (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Interacts (via N-terminal region) with SHANK2 (via proline-rich region); the interaction is increased in a PKA-dependent manner. Q01063; P34971: Adrb1; NbExp=3; IntAct=EBI-7764239, EBI-7764182; Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Apical cell membrane Note=Colocalized with SHANK2 to the apical membrane of colonic crypt cells (By similarity). Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome. Event=Alternative splicing; Named isoforms=3; Name=7; Synonyms=PDE4D7; IsoId=Q01063-1; Sequence=Displayed; Name=9; Synonyms=PDE4D9; IsoId=Q01063-2; Sequence=VSP_012395, VSP_012396; Name=3; IsoId=Q01063-3; Sequence=VSP_012394, VSP_012397; Expressed in brain (at protein level). Isoform 7 is detected in heart, brain, lung, kidney and testis. Up-regulated by cAMP and follicle-stimulating hormone. Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. regulation of heart rate 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding cytoplasm centrosome microtubule organizing center cytosol cytoskeleton plasma membrane voltage-gated calcium channel complex cAMP catabolic process smooth muscle contraction signal transduction aging phosphoric diester hydrolase activity drug binding regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum membrane apical plasma membrane hydrolase activity cAMP binding neutrophil chemotaxis nuclear membrane positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-5 production negative regulation of peptidyl-serine phosphorylation calcium channel complex multicellular organism growth negative regulation of cAMP-mediated signaling ion channel binding negative regulation of heart contraction metal ion binding T cell receptor signaling pathway leukocyte migration ATPase binding regulation of ryanodine-sensitive calcium-release channel activity establishment of endothelial barrier cellular response to lipopolysaccharide cellular response to epinephrine stimulus regulation of cardiac muscle cell contraction scaffold protein binding regulation of cell communication by electrical coupling involved in cardiac conduction negative regulation of relaxation of cardiac muscle uc288pwf.1 uc288pwf.2 
ENSMUST00000074113.13 Prom1 ENSMUST00000074113.13 prominin 1, transcript variant 2 (from RefSeq NM_001163577.1) ENSMUST00000074113.1 ENSMUST00000074113.10 ENSMUST00000074113.11 ENSMUST00000074113.12 ENSMUST00000074113.2 ENSMUST00000074113.3 ENSMUST00000074113.4 ENSMUST00000074113.5 ENSMUST00000074113.6 ENSMUST00000074113.7 ENSMUST00000074113.8 ENSMUST00000074113.9 G5E8G5 G5E8G5_MOUSE NM_001163577 Prom1 uc008xig.1 uc008xig.2 uc008xig.3 uc008xig.4 Cell projection, microvillus membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the prominin family. endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment plasma membrane cell surface membrane integral component of membrane photoreceptor outer segment membrane actinin binding cadherin binding photoreceptor cell maintenance retina morphogenesis in camera-type eye camera-type eye photoreceptor cell differentiation extracellular exosome glomerular visceral epithelial cell differentiation glomerular parietal epithelial cell differentiation positive regulation of nephron tubule epithelial cell differentiation uc008xig.1 uc008xig.2 uc008xig.3 uc008xig.4 
ENSMUST00000074127.14 Aldh3a2 ENSMUST00000074127.14 aldehyde dehydrogenase family 3, subfamily A2, transcript variant 2 (from RefSeq NM_007437.6) AL3A2_MOUSE Ahd-3 Ahd3 Aldh3 Aldh4 ENSMUST00000074127.1 ENSMUST00000074127.10 ENSMUST00000074127.11 ENSMUST00000074127.12 ENSMUST00000074127.13 ENSMUST00000074127.2 ENSMUST00000074127.3 ENSMUST00000074127.4 ENSMUST00000074127.5 ENSMUST00000074127.6 ENSMUST00000074127.7 ENSMUST00000074127.8 ENSMUST00000074127.9 NM_007437 P47740 Q99L64 uc007jhf.1 uc007jhf.2 uc007jhf.3 uc007jhf.4 Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:25286108). Responsible for conversion of the sphingosine 1- phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:25286108). Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence=; Reaction=a fatty aldehyde + H2O + NAD(+) = a fatty acid + 2 H(+) + NADH; Xref=Rhea:RHEA:49832, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:35746, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+); Xref=Rhea:RHEA:33739, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17600, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate; Xref=Rhea:RHEA:44100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:25646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=(2E)-hexadecenal + H2O + NAD(+) = (E)-hexadec-2-enoate + 2 H(+) + NADH; Xref=Rhea:RHEA:36135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17585, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:72745; Evidence=; Reaction=22-oxodocosanoate + H2O + NAD(+) = docosanedioate + 2 H(+) + NADH; Xref=Rhea:RHEA:39015, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76298, ChEBI:CHEBI:76299; Evidence=; Reaction=2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) = 2,6,10,14- tetramethylpentadecanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:44016, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:49189, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:77268; Evidence=; Reaction=H2O + NAD(+) + octadecanal = 2 H(+) + NADH + octadecanoate; Xref=Rhea:RHEA:44020, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17034, ChEBI:CHEBI:25629, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=dodecanoate + 2 H(+) + NADH = dodecanal + H2O + NAD(+); Xref=Rhea:RHEA:44168, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:27836, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=decanal + H2O + NAD(+) = decanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:44104, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:31457, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=H2O + NAD(+) + tetradecanal = 2 H(+) + NADH + tetradecanoate; Xref=Rhea:RHEA:44172, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:84067; Evidence=; Reaction=H2O + heptanal + NAD(+) = 2 H(+) + heptanoate + NADH; Xref=Rhea:RHEA:44108, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32362, ChEBI:CHEBI:34787, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=(2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH; Xref=Rhea:RHEA:24216, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15894, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83276; EC=1.2.1.94; Evidence=; Homodimer. Membrane Microsome membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein ; Cytoplasmic side Belongs to the aldehyde dehydrogenase family. response to reactive oxygen species 3-chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity nucleus mitochondrion mitochondrial inner membrane peroxisome endoplasmic reticulum endoplasmic reticulum membrane cytosol cellular aldehyde metabolic process lipid metabolic process fatty acid metabolic process sesquiterpenoid metabolic process central nervous system development peripheral nervous system development epidermis development membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor organelle membrane phytol metabolic process extrinsic component of endoplasmic reticulum membrane protein homodimerization activity intracellular membrane-bounded organelle glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity formaldehyde metabolic process hexadecanal metabolic process long-chain-alcohol oxidase activity long-chain-aldehyde dehydrogenase activity medium-chain-aldehyde dehydrogenase activity oxidation-reduction process uc007jhf.1 uc007jhf.2 uc007jhf.3 uc007jhf.4 
ENSMUST00000074132.7 Vmn1r59 ENSMUST00000074132.7 vomeronasal 1 receptor 59 (from RefSeq NM_207543.1) ENSMUST00000074132.1 ENSMUST00000074132.2 ENSMUST00000074132.3 ENSMUST00000074132.4 ENSMUST00000074132.5 ENSMUST00000074132.6 NM_207543 Q8R2B9 Q8R2B9_MOUSE V1rd10 Vmn1r59 uc009fah.1 uc009fah.2 uc009fah.3 uc009fah.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009fah.1 uc009fah.2 uc009fah.3 uc009fah.4 
ENSMUST00000074142.7 Lce1a1 ENSMUST00000074142.7 late cornified envelope 1A1 (from RefSeq NM_025984.2) ENSMUST00000074142.1 ENSMUST00000074142.2 ENSMUST00000074142.3 ENSMUST00000074142.4 ENSMUST00000074142.5 ENSMUST00000074142.6 Lce1a1 NM_025984 Q9CQH5 Q9CQH5_MOUSE Sprrl3 uc008qei.1 uc008qei.2 uc008qei.3 Belongs to the LCE family. epidermis development uc008qei.1 uc008qei.2 uc008qei.3 
ENSMUST00000074144.11 Dcaf8 ENSMUST00000074144.11 DDB1 and CUL4 associated factor 8, transcript variant 4 (from RefSeq NM_001421210.1) D1Ucla4 DCAF8_MOUSE ENSMUST00000074144.1 ENSMUST00000074144.10 ENSMUST00000074144.2 ENSMUST00000074144.3 ENSMUST00000074144.4 ENSMUST00000074144.5 ENSMUST00000074144.6 ENSMUST00000074144.7 ENSMUST00000074144.8 ENSMUST00000074144.9 H326 NM_001421210 Q8CII7 Q8CIK6 Q8N7N5 Wdr42a uc007dpx.1 uc007dpx.2 uc007dpx.3 uc007dpx.4 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Protein modification; protein ubiquitination. Interacts with DDB1, CUL4A and CUL4B. Interacts with KPNA1, KPNB1 and XPO1. Nucleus Cytoplasm Note=It shuttles between the nucleus and the cytoplasm. Nuclear import is mediated by KPNA1 and KPNB1 under the regulation of nuclear GTPase RAN. Nuclear export to the cytoplasm is XPO1 dependent. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N7N5-1; Sequence=Displayed; Name=2; IsoId=Q8N7N5-2; Sequence=VSP_027266, VSP_027267; Expressed in the brain. Expressed in the brain at 8.5 dpc, 9.5 dpc and 10.5 dpc. The homozygous loop-tail (Lp) mouse has a severe neural tube closure defect, analogous to the craniorachischisis phenotype seen in humans. This gene has been mapped to The Lp critical region. Belongs to the WD repeat DCAF8 family. Sequence=AAH23704.1; Type=Erroneous initiation; Evidence=; molecular_function nucleus nucleoplasm cytoplasm mitochondrion cytosol biological_process protein ubiquitination Cul4-RING E3 ubiquitin ligase complex uc007dpx.1 uc007dpx.2 uc007dpx.3 uc007dpx.4 
ENSMUST00000074148.7 Gm7361 ENSMUST00000074148.7 predicted gene 7361 (from RefSeq NM_001281527.1) D3Z6R1 D3Z6R1_MOUSE ENSMUST00000074148.1 ENSMUST00000074148.2 ENSMUST00000074148.3 ENSMUST00000074148.4 ENSMUST00000074148.5 ENSMUST00000074148.6 Gm7361 NM_001281527 uc033iic.1 uc033iic.2 uc033iic.3 molecular_function cellular_component biological_process uc033iic.1 uc033iic.2 uc033iic.3 
ENSMUST00000074156.7 Ak8 ENSMUST00000074156.7 adenylate kinase 8 (from RefSeq NM_001033874.2) ENSMUST00000074156.1 ENSMUST00000074156.2 ENSMUST00000074156.3 ENSMUST00000074156.4 ENSMUST00000074156.5 ENSMUST00000074156.6 KAD8_MOUSE NM_001033874 Q32M07 Q497L2 uc008izd.1 uc008izd.2 uc008izd.3 Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3; Evidence=; Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Interacts with CFAP45 and CFAP52; CFAP45 and AK8 dimerization may create a cavity at the interface of the dimer that can accommodate AMP. Cytoplasm, cytosol Cytoplasm, cytoskeleton, cilium axoneme Note=Located in the proximal region of respiratory cilia. Belongs to the adenylate kinase family. nucleotide binding adenylate kinase activity cytidylate kinase activity nucleoside diphosphate kinase activity ATP binding cytoplasm cytosol axoneme nucleobase-containing compound metabolic process nucleoside diphosphate phosphorylation nucleoside triphosphate biosynthetic process kinase activity phosphorylation transferase activity nucleobase-containing compound kinase activity ventricular system development sperm flagellum nucleoside monophosphate phosphorylation uc008izd.1 uc008izd.2 uc008izd.3 
ENSMUST00000074157.13 Myo5b ENSMUST00000074157.13 myosin VB (from RefSeq NM_201600.2) ENSMUST00000074157.1 ENSMUST00000074157.10 ENSMUST00000074157.11 ENSMUST00000074157.12 ENSMUST00000074157.2 ENSMUST00000074157.3 ENSMUST00000074157.4 ENSMUST00000074157.5 ENSMUST00000074157.6 ENSMUST00000074157.7 ENSMUST00000074157.8 ENSMUST00000074157.9 G5E8G6 G5E8G6_MOUSE Myo5b NM_201600 uc008fpp.1 uc008fpp.2 uc008fpp.3 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. nucleotide binding motor activity actin binding ATP binding myosin complex actin filament binding uc008fpp.1 uc008fpp.2 uc008fpp.3 
ENSMUST00000074171.10 Otof ENSMUST00000074171.10 otoferlin, transcript variant 2 (from RefSeq NM_031875.2) E9PYR6 E9PYR6_MOUSE ENSMUST00000074171.1 ENSMUST00000074171.2 ENSMUST00000074171.3 ENSMUST00000074171.4 ENSMUST00000074171.5 ENSMUST00000074171.6 ENSMUST00000074171.7 ENSMUST00000074171.8 ENSMUST00000074171.9 NM_031875 Otof uc008wvk.1 uc008wvk.2 uc008wvk.3 calcium ion binding membrane integral component of membrane synaptic vesicle exocytosis presynapse uc008wvk.1 uc008wvk.2 uc008wvk.3 
ENSMUST00000074173.4 Spatc1 ENSMUST00000074173.4 spermatogenesis and centriole associated 1 (from RefSeq NM_028852.1) A0A0R4J0X4 A0A0R4J0X4_MOUSE ENSMUST00000074173.1 ENSMUST00000074173.2 ENSMUST00000074173.3 NM_028852 Spatc1 uc007wjm.1 uc007wjm.2 centrosome uc007wjm.1 uc007wjm.2 
ENSMUST00000074208.6 Ndufaf3 ENSMUST00000074208.6 NADH:ubiquinone oxidoreductase complex assembly factor 3 (from RefSeq NM_023247.2) ENSMUST00000074208.1 ENSMUST00000074208.2 ENSMUST00000074208.3 ENSMUST00000074208.4 ENSMUST00000074208.5 NDUF3_MOUSE NM_023247 Q8K1A3 Q9JKL4 uc009rqh.1 uc009rqh.2 uc009rqh.3 Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Interacts with NDUFAF4, NDUFS2 and NDUFS3. Nucleus Mitochondrion inner membrane Strongly expressed in testis and weakly expressed in the epididymis. Expressed in spermatocytes. molecular_function nucleus mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain complex I assembly uc009rqh.1 uc009rqh.2 uc009rqh.3 
ENSMUST00000074221.2 Or9i1 ENSMUST00000074221.2 olfactory receptor family 9 subfamily I member 1 (from RefSeq NM_146797.1) ENSMUST00000074221.1 NM_146797 Olfr1502 Or9i1 Q8VG66 Q8VG66_MOUSE uc008gwe.1 uc008gwe.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC106810.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gwe.1 uc008gwe.2 
ENSMUST00000074225.11 Cpne6 ENSMUST00000074225.11 copine VI, transcript variant 4 (from RefSeq NM_001360193.1) CPNE6_MOUSE Cpne6 ENSMUST00000074225.1 ENSMUST00000074225.10 ENSMUST00000074225.2 ENSMUST00000074225.3 ENSMUST00000074225.4 ENSMUST00000074225.5 ENSMUST00000074225.6 ENSMUST00000074225.7 ENSMUST00000074225.8 ENSMUST00000074225.9 NM_001360193 Q9Z140 uc007tyr.1 uc007tyr.2 uc007tyr.3 Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2018]. Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (PubMed:9886090). Plays a role in dendrite formation by melanocytes (By similarity). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts (via second C2 domain) with OS9 (via C-terminus); this interaction occurs in a calcium-dependent manner in vitro (PubMed:10403379). May interact with NECAB1 (By similarity). Cytoplasm ll membrane Endosome Cytoplasmic vesicle, clathrin-coated vesicle Perikaryon Cell projection, dendrite Note=Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium (PubMed:9886090). Translocates to the cell membrane in a calcium- dependent manner (PubMed:21087455, PubMed:26175110). Colocalized with transferrin in intracellular clathrin-coated membrane vesicles in a calcium-dependent manner (PubMed:21087455). Expressed in the brain (PubMed:9645480). Expressed in pyramidal cells, granule cells, and neurons in the dentate gyrus of the hippocampus and in granule cells of the olfactory bulb (at protein level). Expressed in pyramidal cells of the CA1-CA3 regions, in granule cells of the dentate gyrus, in granule cells of the olfactory bulbs, in the mitral cell layer and in neurons of the cerebral cortex layer II, brainstem and spinal cord (PubMed:9886090). Not detected in glial cells (PubMed:9645480, PubMed:9886090). Up-regulated by long-term potentiation (PubMed:9645480). Up- regulated by kainate in an NMDA-type glutamate receptor-dependent manner (PubMed:9645480). The C2 domain 1 binds phospholipids in a calcium-independent manner and is not necessary for calcium-mediated translocation and association to the plasma membrane (PubMed:9886090, PubMed:26175110). The C2 domain 2 binds phospholipids in a calcium-dependent manner and is necessary for calcium-mediated translocation and association to the plasma membrane (PubMed:9886090, PubMed:26175110). The linker region contributes to the calcium-dependent translocation and association to the plasma membrane (PubMed:21087455, PubMed:26175110). The VWFA domain is necessary for association with intracellular clathrin-coated vesicles in a calcium-dependent manner (PubMed:21087455). Belongs to the copine family. phosphatidylserine binding protein binding calcium-dependent phospholipid binding cytoplasm endosome plasma membrane membrane clathrin-coated vesicle cell differentiation axon dendrite cytoplasmic vesicle cell projection perikaryon clathrin-coated endocytic vesicle cellular response to calcium ion positive regulation of dendrite extension uc007tyr.1 uc007tyr.2 uc007tyr.3 
ENSMUST00000074231.6 Vamp5 ENSMUST00000074231.6 vesicle-associated membrane protein 5, transcript variant 1 (from RefSeq NM_016872.4) ENSMUST00000074231.1 ENSMUST00000074231.2 ENSMUST00000074231.3 ENSMUST00000074231.4 ENSMUST00000074231.5 NM_016872 Q9Z2P8 VAMP5_MOUSE uc009cil.1 uc009cil.2 uc009cil.3 uc009cil.4 May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking. Cell membrane ; Single-pass type IV membrane protein Endomembrane system ; Single-pass type IV membrane protein Golgi apparatus, trans-Golgi network membrane ; Single-pass type IV membrane protein Note=Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus. Preferentially expressed in the skeletal muscle and heart, detected at lower levels in several other tissues but not in the brain. During myogenesis. Belongs to the synaptobrevin family. late endosome Golgi apparatus trans-Golgi network plasma membrane integral component of plasma membrane multicellular organism development muscle organ development skeletal muscle tissue development cell surface endomembrane system intercalated disc membrane integral component of membrane vesicle-mediated transport cell differentiation cytoplasmic vesicle membrane integral component of organelle membrane Golgi to plasma membrane protein transport perinuclear region of cytoplasm uc009cil.1 uc009cil.2 uc009cil.3 uc009cil.4 
ENSMUST00000074232.7 Etd ENSMUST00000074232.7 embryonic testis differentiation (from RefSeq NM_175147.2) ENSMUST00000074232.1 ENSMUST00000074232.2 ENSMUST00000074232.3 ENSMUST00000074232.4 ENSMUST00000074232.5 ENSMUST00000074232.6 ETD_MOUSE Etd NM_175147 Q80SW5 uc009tfc.1 uc009tfc.2 uc009tfc.3 Specifically expressed in testis. Not detected at 9.5 dpc and 10.5 dpc. Specifically expressed in male and not female gonads during their differentiation, from 12.5 dpc to 14.5 dpc. molecular_function cellular_component biological_process uc009tfc.1 uc009tfc.2 uc009tfc.3 
ENSMUST00000074233.12 Synm ENSMUST00000074233.12 synemin, intermediate filament protein, transcript variant 1 (from RefSeq NM_201639.2) Dmn ENSMUST00000074233.1 ENSMUST00000074233.10 ENSMUST00000074233.11 ENSMUST00000074233.2 ENSMUST00000074233.3 ENSMUST00000074233.4 ENSMUST00000074233.5 ENSMUST00000074233.6 ENSMUST00000074233.7 ENSMUST00000074233.8 ENSMUST00000074233.9 Kiaa0353 NM_201639 Q3UPZ4 Q6A081 Q70IV3 Q70IV4 Q70IV5 SYNEM_MOUSE Synm uc009hiw.1 uc009hiw.2 uc009hiw.3 Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells (By similarity). Interacts with DES, DMD, DTNA, TLN1, UTRN and VCL (By similarity). Isoform 1 and isoform 2 interact with GFAP and VIM. Q70IV5; A2ASS6: Ttn; NbExp=3; IntAct=EBI-9989763, EBI-9672947; Cytoplasm, cytoskeleton Cell junction, adherens junction Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z- lines, and another in which it interacts with both DTNA and DES at the costamere. Event=Alternative splicing; Named isoforms=3; Name=1 ; Synonyms=H ; IsoId=Q70IV5-1; Sequence=Displayed; Name=2 ; Synonyms=M ; IsoId=Q70IV5-2; Sequence=VSP_053035; Name=3 ; Synonyms=L ; IsoId=Q70IV5-3; Sequence=VSP_053033, VSP_053034; Isoform 2 and isoform 3 are detected in adult skeletal muscle, heart and bladder, whereas isoform 1 is only detected in adult bladder (at protein level). At 11.5 dpc, isoform 1 and isoform 2 are widely expressed in the developing nervous and vascular systems and are also found specifically associated with vimentin in endothelial cells. By 15 dpc, isoform 1, isoform 2 and isoform 3, are found coexpressed with neurofilament, peripherin and internexin in the peripheral nervous system (at protein level). In the developing embryo, isoform 2 is detected as early as 5 dpc, whereas isoform 1 is first observed at 9 dpc in the nervous system and mesodermic derivatives. Isoform 3 is observed later in neurons at 15 dpc. Up-regulated in reactive astrocytes following neurotrauma (at protein level). Belongs to the intermediate filament family. structural constituent of cytoskeleton protein binding cytoplasm cytoskeleton intermediate filament adherens junction structural constituent of muscle membrane vinculin binding intermediate filament binding Z disc cell junction protein binding, bridging fast-twitch skeletal muscle fiber contraction sarcolemma costamere intermediate filament cytoskeleton organization neurofilament cytoskeleton uc009hiw.1 uc009hiw.2 uc009hiw.3 
ENSMUST00000074240.4 Dipk1b ENSMUST00000074240.4 divergent protein kinase domain 1B (from RefSeq NM_019833.3) DIK1B_MOUSE ENSMUST00000074240.1 ENSMUST00000074240.2 ENSMUST00000074240.3 Fam69b NM_019833 Pip49 Q0VG43 Q80UM6 Q99ML4 Q9JMG0 uc012bsn.1 uc012bsn.2 Endoplasmic reticulum membrane ; Single-pass type II membrane protein Expressed in kidney, testis, lung, heart, stomach, intestine, pancreas, liver and salivary gland. Strongly expressed in acute pancreatitis, brain, and in peripheral endothelial cells. Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds. Belongs to the DIPK family. Sequence=AAH51954.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH60081.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI16752.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAA92750.1; Type=Frameshift; Evidence=; molecular_function cellular_component endoplasmic reticulum endoplasmic reticulum membrane biological_process membrane integral component of membrane uc012bsn.1 uc012bsn.2 
ENSMUST00000074253.4 Krt40 ENSMUST00000074253.4 keratin 40, transcript variant 1 (from RefSeq NM_001039666.3) A0AUL0 ENSMUST00000074253.1 ENSMUST00000074253.2 ENSMUST00000074253.3 K1C40_MOUSE Ka36 NM_001039666 Q3B7Y6 Q6IFX3 uc007liy.1 uc007liy.2 May play a role in late hair differentiation. Heterotetramer of two type I and two type II keratins. There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively). Belongs to the intermediate filament family. structural molecule activity intermediate filament biological_process uc007liy.1 uc007liy.2 
ENSMUST00000074259.15 Nrm ENSMUST00000074259.15 nurim (nuclear envelope membrane protein) (from RefSeq NM_134122.2) ENSMUST00000074259.1 ENSMUST00000074259.10 ENSMUST00000074259.11 ENSMUST00000074259.12 ENSMUST00000074259.13 ENSMUST00000074259.14 ENSMUST00000074259.2 ENSMUST00000074259.3 ENSMUST00000074259.4 ENSMUST00000074259.5 ENSMUST00000074259.6 ENSMUST00000074259.7 ENSMUST00000074259.8 ENSMUST00000074259.9 NM_134122 NRM_MOUSE Q8VC65 uc008cis.1 uc008cis.2 uc008cis.3 Nucleus inner membrane ; Multi-pass membrane protein Belongs to the nurim family. molecular_function nucleus nuclear envelope nuclear inner membrane nuclear lamina biological_process membrane integral component of membrane nuclear membrane uc008cis.1 uc008cis.2 uc008cis.3 
ENSMUST00000074262.9 Calcrl ENSMUST00000074262.9 calcitonin receptor-like (from RefSeq NM_018782.2) CALRL_MOUSE Crlr ENSMUST00000074262.1 ENSMUST00000074262.2 ENSMUST00000074262.3 ENSMUST00000074262.4 ENSMUST00000074262.5 ENSMUST00000074262.6 ENSMUST00000074262.7 ENSMUST00000074262.8 NM_018782 Q9QXH8 Q9R1W5 Q9WUP2 uc008kii.1 uc008kii.2 uc008kii.3 uc008kii.4 uc008kii.5 uc008kii.6 Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2 (By similarity). Cell membrane; Multi-pass membrane protein. Expressed predominantly in the lung, thymus, heart and brain. Belongs to the G-protein coupled receptor 2 family. angiogenesis adrenomedullin receptor activity calcitonin gene-related peptide receptor activity transmembrane signaling receptor activity G-protein coupled receptor activity calcitonin receptor activity cytoplasm lysosome endosome endoplasmic reticulum plasma membrane calcium ion transport signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway heart development positive regulation of cell proliferation protein transport membrane integral component of membrane receptor internalization negative regulation of smooth muscle contraction positive regulation of smooth muscle cell proliferation negative regulation of inflammatory response cellular response to sucrose stimulus adrenomedullin receptor complex CGRP receptor complex calcitonin gene-related peptide receptor signaling pathway adrenomedullin binding adrenomedullin receptor signaling pathway uc008kii.1 uc008kii.2 uc008kii.3 uc008kii.4 uc008kii.5 uc008kii.6 
ENSMUST00000074267.5 Rps7 ENSMUST00000074267.5 ribosomal protein S7 (from RefSeq NM_011300.3) ENSMUST00000074267.1 ENSMUST00000074267.2 ENSMUST00000074267.3 ENSMUST00000074267.4 NM_011300 Q4FZE6 Q4FZE6_MOUSE Rps7 Rps7A uc007nfs.1 uc007nfs.2 uc007nfs.3 uc007nfs.4 Belongs to the eukaryotic ribosomal protein eS7 family. mRNA 3'-UTR binding structural constituent of ribosome nucleus nucleolus centrosome ribosome rRNA processing translation poly(U) RNA binding positive regulation of gene expression protein kinase binding cytosolic small ribosomal subunit macromolecular complex ribosomal small subunit biogenesis mRNA 5'-UTR binding protein stabilization positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of ubiquitin protein ligase activity ribonucleoprotein complex ubiquitin ligase inhibitor activity negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc007nfs.1 uc007nfs.2 uc007nfs.3 uc007nfs.4 
ENSMUST00000074301.10 Smyd1 ENSMUST00000074301.10 SET and MYND domain containing 1, transcript variant 1 (from RefSeq NM_001160127.1) Bop ENSMUST00000074301.1 ENSMUST00000074301.2 ENSMUST00000074301.3 ENSMUST00000074301.4 ENSMUST00000074301.5 ENSMUST00000074301.6 ENSMUST00000074301.7 ENSMUST00000074301.8 ENSMUST00000074301.9 NM_001160127 P97442 P97443 P97444 Q6DFW7 SMYD1_MOUSE uc009cgj.1 uc009cgj.2 uc009cgj.3 Methylates histone H3 at 'Lys-4' (H3K4me). Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis. Reaction=L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60260, Rhea:RHEA-COMP:15537, Rhea:RHEA- COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.354; Evidence=; Interacts with HDAC1, HDAC2 and HDAC3. Interacts (via MYND- type zinc finger) with NACA isoform skNAC. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=ISKM-BOP1 ; IsoId=P97443-1; Sequence=Displayed; Name=2; Synonyms=SKM-BOP2 ; IsoId=P97443-2; Sequence=VSP_050403, VSP_050404; Name=3; Synonyms=T-BOP ; IsoId=P97443-3; Sequence=VSP_050402; Expressed in cardiac and skeletal muscle, lymphocytes and thymus. The SET domain is split between the S-sequence (residues 1-49) and the core SET domain (residues 181-258), however the two segments still come together to form a conserved SET domain fold. Belongs to the class V-like SAM-binding methyltransferase superfamily. Sequence=AAC53021.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAC53022.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; DNA binding transcription corepressor activity protein binding nucleus cytoplasm chromatin remodeling heart development methyltransferase activity positive regulation of myotube differentiation transferase activity histone-lysine N-methyltransferase activity methylation histone lysine methylation skeletal muscle cell differentiation positive regulation of myoblast differentiation negative regulation of transcription, DNA-templated metal ion binding uc009cgj.1 uc009cgj.2 uc009cgj.3 
ENSMUST00000074343.6 Defa26 ENSMUST00000074343.6 defensin, alpha, 26 (from RefSeq NM_001079933.2) DFA26_MOUSE Defcr26 ENSMUST00000074343.1 ENSMUST00000074343.2 ENSMUST00000074343.3 ENSMUST00000074343.4 ENSMUST00000074343.5 NM_001079933 Q3L180 uc009lbs.1 uc009lbs.2 uc009lbs.3 uc009lbs.4 May have microbicidal activities. Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc009lbs.1 uc009lbs.2 uc009lbs.3 uc009lbs.4 
ENSMUST00000074352.11 Osbpl1a ENSMUST00000074352.11 oxysterol binding protein-like 1A, transcript variant 1 (from RefSeq NM_207530.3) ENSMUST00000074352.1 ENSMUST00000074352.10 ENSMUST00000074352.2 ENSMUST00000074352.3 ENSMUST00000074352.4 ENSMUST00000074352.5 ENSMUST00000074352.6 ENSMUST00000074352.7 ENSMUST00000074352.8 ENSMUST00000074352.9 NM_207530 O88318 OSBL1_MOUSE Orp1 Orp1a Orp1l Osbpl1a Q3TH97 Q673L8 Q6DFU6 Q91XL9 uc008ecu.1 uc008ecu.2 uc008ecu.3 uc008ecu.4 Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol. Interacts (via FFAT motif) with VAPA and VAPB (By similarity). Interacts with the GTP-bound form of RAB7A (By similarity). Interacts with OAS1B (PubMed:22623793). Interacts (via FFAT motif) with MOSPD2 (via MSP domain) (By similarity). Late endosome Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Osbpl1b; IsoId=Q91XL9-1; Sequence=Displayed; Name=2; Synonyms=Osbpl1a; IsoId=Q91XL9-2; Sequence=VSP_017724; Name=3; IsoId=Q91XL9-3; Sequence=VSP_017723; Ubiquitous. The FFAT motif is required for interaction with MOSPD2. The FFAT motif is required for interaction with MOSPD2, VAPA and VAPB. Belongs to the OSBP family. protein binding endosome late endosome cytosol lipid transport lipid binding cholesterol binding membrane sterol binding intracellular membrane-bounded organelle uc008ecu.1 uc008ecu.2 uc008ecu.3 uc008ecu.4 
ENSMUST00000074359.4 Klk1b5 ENSMUST00000074359.4 kallikrein 1-related peptidase b5 (from RefSeq NM_008456.4) ENSMUST00000074359.1 ENSMUST00000074359.2 ENSMUST00000074359.3 K1KB5_MOUSE Klk-5 Klk5 NM_008456 P15945 Q52KM1 Q565D7 uc009gon.1 uc009gon.2 uc009gon.3 uc009gon.4 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC094281.1, BG870715.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Reaction=Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl- bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|- Xaa.; EC=3.4.21.35; Belongs to the peptidase S1 family. Kallikrein subfamily. regulation of systemic arterial blood pressure endopeptidase activity serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides secretory granule zymogen activation macromolecular complex uc009gon.1 uc009gon.2 uc009gon.3 uc009gon.4 
ENSMUST00000074368.11 Slc35f4 ENSMUST00000074368.11 solute carrier family 35, member F4 (from RefSeq NM_029238.2) B8JJY8 ENSMUST00000074368.1 ENSMUST00000074368.10 ENSMUST00000074368.2 ENSMUST00000074368.3 ENSMUST00000074368.4 ENSMUST00000074368.5 ENSMUST00000074368.6 ENSMUST00000074368.7 ENSMUST00000074368.8 ENSMUST00000074368.9 MNCb-0335 NM_029238 Q8BL81 Q8BXC4 Q8BZK4 Q9JJG8 S35F4_MOUSE uc007tkf.1 uc007tkf.2 uc007tkf.3 Putative solute transporter. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BZK4-1; Sequence=Displayed; Name=2; IsoId=Q8BZK4-2; Sequence=VSP_029670, VSP_029671; Name=3; IsoId=Q8BZK4-3; Sequence=VSP_029672, VSP_029673; Belongs to the SLC35F solute transporter family. molecular_function cellular_component biological_process membrane integral component of membrane transmembrane transporter activity transmembrane transport uc007tkf.1 uc007tkf.2 uc007tkf.3 
ENSMUST00000074371.13 Pdcd4 ENSMUST00000074371.13 programmed cell death 4, transcript variant 1 (from RefSeq NM_011050.4) ENSMUST00000074371.1 ENSMUST00000074371.10 ENSMUST00000074371.11 ENSMUST00000074371.12 ENSMUST00000074371.2 ENSMUST00000074371.3 ENSMUST00000074371.4 ENSMUST00000074371.5 ENSMUST00000074371.6 ENSMUST00000074371.7 ENSMUST00000074371.8 ENSMUST00000074371.9 Ma3 NM_011050 P97296 PDCD4_MOUSE Q3T9A9 Q61823 Tis uc008hxb.1 uc008hxb.2 uc008hxb.3 uc008hxb.4 Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA. Interacts (via MI domains) with EIF4A1 and EIF4A2 (via N- terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11 (By similarity). Q61823; P60843: Eif4a1; NbExp=4; IntAct=EBI-296473, EBI-6665935; Q61823; Q62448: Eif4g2; NbExp=2; IntAct=EBI-296473, EBI-296494; Nucleus Cytoplasm Note=Shuttles between the nucleus and cytoplasm (PubMed:12894233). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (By similarity). Expressed ubiquitously. Highyly expressed in thymus and liver. Moderately expressed in brain, kidney and spleen; weakly in lung and heart. Expression is up- or down-regulated in response to apoptosis inducers. Regulated by many programmed cell death-inducing stimuli. Binds EIF4A1 via both MI domains. Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation (By similarity). Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4. Note=Decreases benign tumor development and malignant progression. Belongs to the PDCD4 family. RNA binding protein binding nucleus cytoplasm cytosol apoptotic process cell aging BMP signaling pathway positive regulation of smooth muscle cell apoptotic process negative regulation of apoptotic process negative regulation of JUN kinase activity negative regulation of transcription, DNA-templated positive regulation of inflammatory response regulation of protein metabolic process epithelial to mesenchymal transition involved in cardiac fibroblast development cellular response to lipopolysaccharide negative regulation of cytokine production involved in inflammatory response positive regulation of NIK/NF-kappaB signaling negative regulation of vascular smooth muscle cell proliferation negative regulation of myofibroblast differentiation negative regulation of vascular smooth muscle cell differentiation positive regulation of vascular associated smooth muscle cell apoptotic process positive regulation of endothelial cell apoptotic process uc008hxb.1 uc008hxb.2 uc008hxb.3 uc008hxb.4 
ENSMUST00000074372.6 Irx2 ENSMUST00000074372.6 Iroquois homeobox 2 (from RefSeq NM_010574.4) ENSMUST00000074372.1 ENSMUST00000074372.2 ENSMUST00000074372.3 ENSMUST00000074372.4 ENSMUST00000074372.5 IRX2_MOUSE Irx6 Irxa2 NM_010574 O55121 P81066 Q3UFG3 Q9ERN1 Q9JLL4 uc007rde.1 uc007rde.2 uc007rde.3 uc007rde.4 Nucleus Expressed in specific and overlapping patterns with Irx1 and Irx3 in the developing and adult metanephric kidney. In the adult metanephros, renal expression is found in the loop of Henle in the S3 proximal tubule segment and in the thick ascending limb (TAL) of the distal tubule. First expressed at 8.0 dpc. During neural tube closure (8.5 dpc), expression appears for the first time in the rhombencephalon in the presumptive region of future rhombomere 4. During neurogenesis (9.5 dpc to 10.5 dpc), predominantly expressed along the anteroposterior axis of the CNS in the mesencephalon, metencephalon and rhombencephalon. Expression is strong in the tectum of the mesencephalon and in the hindbrain, expression is restricted to rhombomeres. Expression in the spinal cord is weak and confined to the alar plate. Beginning at 9.5 dpc, expressed in the epithelial component of the branchial arches and foregut. At 10.5 dpc, expression extends rostrally into the dorsal diencephalon. Starting at the otic vesicle stage, shows regionalized expression in the developing inner ear with expression in the entire otic vesicle from 10.5 dpc onwards. From 10.5 dpc onwards, weak expression begins in the limb bud. Also expressed in other tissues during organogenesis; at 9.5 dpc, expressed in the superficial ectoderm surrounding the body and in the region of the foregut, which will form the pharynx and the lung bud. at 10.5 dpc, found in the cephalic mesenchyme around the optic vesicle. By 12.5 dpc, still expressed in the mesenchyme, and expression begins in specific subsets of post-mitotic cells in the neuroretina. As development ensues, expression increases in the neuroretina and mesenchymal expression gradually decreases. At 16.5 dpc, expressed exclusively in the inner neuroblast layers of the neuroretina. Expressed in the developing heart in the ventricular septum from the onset of its formation (10.5 dpc) onward. In fetal stages, expression becomes confined to the myocardium of the atrioventricular bundle and bundle branches of the forming ventricular conduction system. Belongs to the TALE/IRO homeobox family. Called Irx6 by PubMed:10704856. Sequence=AAF63956.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter metanephros development DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding specification of loop of Henle identity proximal/distal pattern formation involved in metanephric nephron development uc007rde.1 uc007rde.2 uc007rde.3 uc007rde.4 
ENSMUST00000074408.7 Ifnlr1 ENSMUST00000074408.7 interferon lambda receptor 1 (from RefSeq NM_174851.4) ENSMUST00000074408.1 ENSMUST00000074408.2 ENSMUST00000074408.3 ENSMUST00000074408.4 ENSMUST00000074408.5 ENSMUST00000074408.6 INLR1_MOUSE Il28ra NM_174851 Q6PEV1 Q8CGK5 uc008vgw.1 uc008vgw.2 uc008vgw.3 uc008vgw.4 uc008vgw.5 The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)- induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Heterodimer with IL10RB. Membrane ; Single-pass type I membrane protein Ubiquitinated by FBXO45-containing E3 ligase leading to proteasomal degradation. The mice are viable and appear to be of normal size, behavior and reproductive ability. There is no effect on the ability to combat vaginal viral infection, but antiviral response evoked by Toll-like reseptor (TLR) stimulation is reduced. Mice also display enhanced rotavirus susceptibility associated with epithelial vacuolization, villus deformation and epithelial cell disruption. Belongs to the type II cytokine receptor family. mucosal immune response cytokine receptor activity plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway interleukin-28 receptor complex response to type III interferon regulation of defense response to virus by host defense response to virus uc008vgw.1 uc008vgw.2 uc008vgw.3 uc008vgw.4 uc008vgw.5 
ENSMUST00000074416.10 Prima1 ENSMUST00000074416.10 proline rich membrane anchor 1 (from RefSeq NM_133364.2) ENSMUST00000074416.1 ENSMUST00000074416.2 ENSMUST00000074416.3 ENSMUST00000074416.4 ENSMUST00000074416.5 ENSMUST00000074416.6 ENSMUST00000074416.7 ENSMUST00000074416.8 ENSMUST00000074416.9 F8VQJ2 F8VQJ2_MOUSE NM_133364 Prima1 uc007ouz.1 uc007ouz.2 uc007ouz.3 membrane integral component of membrane uc007ouz.1 uc007ouz.2 uc007ouz.3 
ENSMUST00000074449.7 Sprr2a1 ENSMUST00000074449.7 small proline-rich protein 2A1 (from RefSeq NM_011468.4) ENSMUST00000074449.1 ENSMUST00000074449.2 ENSMUST00000074449.3 ENSMUST00000074449.4 ENSMUST00000074449.5 ENSMUST00000074449.6 NM_011468 O70553 Q9CQK8 SP2A1_MOUSE Sprr2a Sprr2a1 uc012cte.1 uc012cte.2 uc012cte.3 Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (By similarity). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (PubMed:34735226). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (By similarity). Secreted Secreted, extracellular space Cytoplasmic vesicle, secretory vesicle Note=Present in intestinal secretory epithelial cells and is secreted into the intestinal lumen. By type-2 cytokines IL4 and IL13 in response to helminth infection. Forms five pairs of intrachain disulfide bonds. Mice lacking Sprr2a1, Sprr2a2 and Sprr2a3 show an expansion of Gram-positive bacteria in the small intestinal lumen and mucus layer (PubMed:34735226). Mice were born in normal Mendelian ratios, are healthy and show normal intestinal morphology with no signs of inflammation in normal conditions (PubMed:34735226). They however show an increased abundance of Gram-positive bacteria in the small intestinal lumen, with a marked increase in the relative abundance of Lactobacillus, Turicibacter, and C.arthromitus (PubMed:34735226). At the same time, a reduction in the abundance of Bacteroidetes, a class of Gram-negative bacteria is observed (PubMed:34735226). Mice are more susceptible to L. monocytogenes infection (PubMed:34735226). Belongs to the cornifin (SPRR) family. cornified envelope structural constituent of cytoskeleton nucleus cytoplasm cytoskeleton organization regulation of cell shape epidermis development keratinocyte differentiation keratinization response to estradiol uc012cte.1 uc012cte.2 uc012cte.3 
ENSMUST00000074455.9 Zfp772 ENSMUST00000074455.9 zinc finger protein 772 (from RefSeq NM_145577.2) BC023179 ENSMUST00000074455.1 ENSMUST00000074455.2 ENSMUST00000074455.3 ENSMUST00000074455.4 ENSMUST00000074455.5 ENSMUST00000074455.6 ENSMUST00000074455.7 ENSMUST00000074455.8 NM_145577 Q3UQL6 Q3UQL6_MOUSE Zfp772 uc009fcl.1 uc009fcl.2 uc009fcl.3 Nucleus nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc009fcl.1 uc009fcl.2 uc009fcl.3 
ENSMUST00000074468.13 Snap91 ENSMUST00000074468.13 synaptosomal-associated protein 91, transcript variant 1 (from RefSeq NM_013669.2) E9QLK9 E9QLK9_MOUSE ENSMUST00000074468.1 ENSMUST00000074468.10 ENSMUST00000074468.11 ENSMUST00000074468.12 ENSMUST00000074468.2 ENSMUST00000074468.3 ENSMUST00000074468.4 ENSMUST00000074468.5 ENSMUST00000074468.6 ENSMUST00000074468.7 ENSMUST00000074468.8 ENSMUST00000074468.9 NM_013669 Snap91 uc292jjf.1 uc292jjf.2 Membrane Belongs to the PICALM/SNAP91 family. phospholipid binding 1-phosphatidylinositol binding clathrin-coated vesicle clathrin binding clathrin coat assembly uc292jjf.1 uc292jjf.2 
ENSMUST00000074519.13 Txnip ENSMUST00000074519.13 thioredoxin interacting protein, transcript variant 1 (from RefSeq NM_001009935.2) ENSMUST00000074519.1 ENSMUST00000074519.10 ENSMUST00000074519.11 ENSMUST00000074519.12 ENSMUST00000074519.2 ENSMUST00000074519.3 ENSMUST00000074519.4 ENSMUST00000074519.5 ENSMUST00000074519.6 ENSMUST00000074519.7 ENSMUST00000074519.8 ENSMUST00000074519.9 NM_001009935 Q8BG60 Q8BGQ0 Q8K2B2 Q9DC00 Q9EP90 Q9R115 TXNIP_MOUSE Vdup1 uc008qnc.1 uc008qnc.2 uc008qnc.3 uc008qnc.4 May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4 (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BG60-1; Sequence=Displayed; Name=2; IsoId=Q8BG60-2; Sequence=VSP_020653; Ubiquitously expressed. Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation. Marked reduction in the numbers of natural killer cells, low levels of Il2rb expression in the precursor hematopoietic stem cells and severe lymphoid hyperplasia in the small intestine. Belongs to the arrestin family. negative regulation of transcription from RNA polymerase II promoter enzyme inhibitor activity protein binding nucleus cytoplasm mitochondrial intermembrane space cytosol protein import into nucleus response to oxidative stress cell cycle response to mechanical stimulus response to glucose keratinocyte differentiation ubiquitin protein ligase binding response to estradiol response to progesterone regulation of cell proliferation response to drug response to hydrogen peroxide positive regulation of apoptotic process negative regulation of catalytic activity platelet-derived growth factor receptor signaling pathway response to calcium ion negative regulation of cell division cellular response to tumor cell uc008qnc.1 uc008qnc.2 uc008qnc.3 uc008qnc.4 
ENSMUST00000074523.13 Stmn4 ENSMUST00000074523.13 stathmin-like 4, transcript variant 2 (from RefSeq NM_019675.4) ENSMUST00000074523.1 ENSMUST00000074523.10 ENSMUST00000074523.11 ENSMUST00000074523.12 ENSMUST00000074523.2 ENSMUST00000074523.3 ENSMUST00000074523.4 ENSMUST00000074523.5 ENSMUST00000074523.6 ENSMUST00000074523.7 ENSMUST00000074523.8 ENSMUST00000074523.9 NM_019675 O35414 O35415 O35416 P63042 STMN4_MOUSE uc007ukf.1 uc007ukf.2 uc007ukf.3 uc007ukf.4 Exhibits microtubule-destabilizing activity. Golgi apparatus Cell projection, growth cone Cell projection, axon Belongs to the stathmin family. cytoplasm Golgi apparatus microtubule depolymerization tubulin binding axon growth cone regulation of microtubule polymerization or depolymerization neuron projection development cell projection neuron projection regulation of cytoskeleton organization uc007ukf.1 uc007ukf.2 uc007ukf.3 uc007ukf.4 
ENSMUST00000074525.10 Gulp1 ENSMUST00000074525.10 GULP, engulfment adaptor PTB domain containing 1 (from RefSeq NM_028450.3) Ced6 ENSMUST00000074525.1 ENSMUST00000074525.2 ENSMUST00000074525.3 ENSMUST00000074525.4 ENSMUST00000074525.5 ENSMUST00000074525.6 ENSMUST00000074525.7 ENSMUST00000074525.8 ENSMUST00000074525.9 GULP1_MOUSE NM_028450 Q8K2A1 Q9CRV4 Q9CYD2 uc007awm.1 uc007awm.2 uc007awm.3 uc007awm.4 Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization of various LRP1 ligands, such as PSAP (By similarity). May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Increases cellular levels of GTP-bound ARF6. Homodimer. Interacts with clathrin and MEGF10 (By similarity). Interacts with GDP-bound ARF6, but not with GTP-bound ARF6. Part of a complex composed of GULP1, ACAP1 and ARF6. Interacts with ACAP1, LRP1 and STAB2. Cytoplasm Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2A1-1; Sequence=Displayed; Name=2; IsoId=Q8K2A1-2; Sequence=VSP_027252; Detected throughout the brain, particularly in Purkinje cells, hippocampal and cortical neurons (at protein level). Belongs to the ced-6 family. Sequence=BAB29151.2; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm lipid transport phagocytosis phagocytosis, engulfment apoptotic process uc007awm.1 uc007awm.2 uc007awm.3 uc007awm.4 
ENSMUST00000074541.6 Jazf1 ENSMUST00000074541.6 JAZF zinc finger 1, transcript variant 1 (from RefSeq NM_173406.4) ENSMUST00000074541.1 ENSMUST00000074541.2 ENSMUST00000074541.3 ENSMUST00000074541.4 ENSMUST00000074541.5 JAZF1_MOUSE NM_173406 Q80ZQ5 Q8BLQ8 Q8BWN4 uc009bzb.1 uc009bzb.2 uc009bzb.3 uc009bzb.4 Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (By similarity). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (PubMed:24380856). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (PubMed:24930994). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (PubMed:24380856, PubMed:25614086). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (PubMed:25614086, PubMed:24380856). Interacts with NR2C2 (via ligand-binding region). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80ZQ5-1; Sequence=Displayed; Name=2; IsoId=Q80ZQ5-2; Sequence=VSP_007756; Expressed in range of tissues with highest expression levels in testis, liver, muscle and fat and lowest levels in kidney (PubMed:25614086). Detected in liver and white adipose tissue (at protein level) (PubMed:24380856). Expression is gradually but significantly up- regulated during adipocyte differentiation. negative regulation of transcription from RNA polymerase II promoter fibrillar center nucleic acid binding transcription corepressor activity nucleus cytosol lipid metabolic process transcriptional repressor complex metal ion binding uc009bzb.1 uc009bzb.2 uc009bzb.3 uc009bzb.4 
ENSMUST00000074552.12 Ncaph2 ENSMUST00000074552.12 non-SMC condensin II complex, subunit H2, transcript variant 1 (from RefSeq NM_001115132.3) CNDH2_MOUSE D15Ertd785e ENSMUST00000074552.1 ENSMUST00000074552.10 ENSMUST00000074552.11 ENSMUST00000074552.2 ENSMUST00000074552.3 ENSMUST00000074552.4 ENSMUST00000074552.5 ENSMUST00000074552.6 ENSMUST00000074552.7 ENSMUST00000074552.8 ENSMUST00000074552.9 NM_001115132 Ncaph2 Q3TNI4 Q8BSP2 Q8C2N3 Q8C3K9 Q8C4X8 Q8CAZ3 Q99L21 Q9CT99 uc007xgh.1 uc007xgh.2 uc007xgh.3 uc007xgh.4 uc007xgh.5 This gene encodes a component of the condensin-2 complex. The encoded protein may regulate the structure of mitotic chromosomes. Loss of function of this gene disrupts T-cell development. There are two pseudogenes for this gene on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]. Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). Seems to have lineage-specific role in T-cell development (By similarity). Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits, NCAPG2, NCAPH2 and NCAPD3 that probably regulate the complex. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BSP2-1; Sequence=Displayed; Name=2; IsoId=Q8BSP2-2; Sequence=VSP_032642; Name=3; IsoId=Q8BSP2-3; Sequence=VSP_032641; Note=Defects in Ncaph2 are the cause of the nessy phenotype which is characterized by a specific defect in T-cell development. Nessy thymuses are smaller, with corticomedullary junctions less well defined, and cortical cells sparser than in wild-type. The thymocyte defect is typified by an increased proportion of CD4-CD8- DN T-cell progenitors. Only thymocyte differentiation is affected in Nessy mice and not cell differentiation. Belongs to the CND2 H2 (condensin-2 subunit 2) family. Sequence=AAH03900.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; condensed chromosome condensin complex chromatin binding nucleus nucleoplasm chromosome mitotic chromosome condensation female meiotic division meiotic chromosome condensation cell junction chromosome condensation T cell differentiation in thymus intercellular bridge chromosome organization mitotic sister chromatid separation female meiosis chromosome separation uc007xgh.1 uc007xgh.2 uc007xgh.3 uc007xgh.4 uc007xgh.5 
ENSMUST00000074556.7 H2aj ENSMUST00000074556.7 H2J.A histone (from RefSeq NM_177688.4) ENSMUST00000074556.1 ENSMUST00000074556.2 ENSMUST00000074556.3 ENSMUST00000074556.4 ENSMUST00000074556.5 ENSMUST00000074556.6 H2AJ_MOUSE H2aj NM_177688 Q8R1M2 uc009eme.1 uc009eme.2 uc009eme.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 6 and encodes a replication-independent histone that is member of the histone H2A family. [provided by RefSeq, Nov 2015]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 15720718 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Chromosome Monoubiquitination of Lys-120 (H2AXK119ub) gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties (By similarity). Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (By similarity). Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription (By similarity). Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc009eme.1 uc009eme.2 uc009eme.3 
ENSMUST00000074570.10 Adgrg5 ENSMUST00000074570.10 adhesion G protein-coupled receptor G5, transcript variant 2 (from RefSeq NM_001033468.3) A6H6A1 AGRG5_MOUSE ENSMUST00000074570.1 ENSMUST00000074570.2 ENSMUST00000074570.3 ENSMUST00000074570.4 ENSMUST00000074570.5 ENSMUST00000074570.6 ENSMUST00000074570.7 ENSMUST00000074570.8 ENSMUST00000074570.9 G5E8G8 Gm1109 Gpr114 NM_001033468 Pgr27 Q3V3Z3 uc009mxi.1 uc009mxi.2 uc009mxi.3 uc009mxi.4 Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway (PubMed:22575658). Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking) (PubMed:26499266). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3V3Z3-1; Sequence=Displayed; Name=2; IsoId=Q3V3Z3-2; Sequence=VSP_058541; Expressed at least in kidney, heart, brain and spleen. In the kidney, both isoform 1 and isoform 2 are expressed at similar levels. Isoform 1 is predominant in spleen, while isoform 2 is the major form in heart and brain. Autoproteolysis between residues Leu-222 and Thr-223 occurs in the lumen of the endoplasmic reticulum during receptor biosynthesis. The N- terminal fragment (NTF) subsequently reassociates with the C-terminal fragment (CTF) either in a homogeneric heterodimerization, or with another family member through heterogeneric heterodimerization. Autocatalytic cleavage is thought to be critical for the maturation, stability, trafficking, and function. [Isoform 2]: May be due to competing acceptor splice site. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. transmembrane signaling receptor activity G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway membrane integral component of membrane uc009mxi.1 uc009mxi.2 uc009mxi.3 uc009mxi.4 
ENSMUST00000074574.13 Unc5cl ENSMUST00000074574.13 unc-5 family C-terminal like (from RefSeq NM_152823.4) E9QLC2 E9QLC2_MOUSE ENSMUST00000074574.1 ENSMUST00000074574.10 ENSMUST00000074574.11 ENSMUST00000074574.12 ENSMUST00000074574.2 ENSMUST00000074574.3 ENSMUST00000074574.4 ENSMUST00000074574.5 ENSMUST00000074574.6 ENSMUST00000074574.7 ENSMUST00000074574.8 ENSMUST00000074574.9 NM_152823 Unc5cl uc008cxz.1 uc008cxz.2 uc008cxz.3 uc008cxz.4 Belongs to the unc-5 family. netrin receptor activity proteolysis signal transduction peptidase activity membrane integral component of membrane netrin-activated signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade uc008cxz.1 uc008cxz.2 uc008cxz.3 uc008cxz.4 
ENSMUST00000074575.11 Snrnp70 ENSMUST00000074575.11 small nuclear ribonucleoprotein 70 (U1), transcript variant 1 (from RefSeq NM_009224.6) ENSMUST00000074575.1 ENSMUST00000074575.10 ENSMUST00000074575.2 ENSMUST00000074575.3 ENSMUST00000074575.4 ENSMUST00000074575.5 ENSMUST00000074575.6 ENSMUST00000074575.7 ENSMUST00000074575.8 ENSMUST00000074575.9 NM_009224 Q3UIW4 Q62376 RU17_MOUSE Snrp70 uc009guw.1 uc009guw.2 uc009guw.3 uc009guw.4 This gene encodes a subunit of the U1 snRNP (small nuclear ribonucleic particle), one of at least five snRNPs to comprise the spliceosome, which functions in processing of pre-mRNAs. The U1 snRNP has been shown to be important in defining the 5' splice site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]. Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1- snRNA. [Isoform 2]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (By similarity). Interacts with SCNM1 (PubMed:17656373). Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Interacts with dephosphorylated SFRS13A and SFPQ. Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2. Interacts with GEMIN5 (By similarity). Interacts with FUS (By similarity). Nucleus speckle Nucleus, nucleoplasm Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q62376-1; Sequence=Displayed; Name=2; IsoId=Q62376-2; Sequence=VSP_005851, VSP_005852; The RRM domain mediates interaction with U1 RNA. Extensively phosphorylated on serine residues in the C-terminal region. mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding nucleus nucleoplasm spliceosomal complex U1 snRNP cytoplasm nuclear speck U1 snRNA binding regulation of RNA splicing positive regulation of mRNA splicing, via spliceosome U2-type prespliceosome U1 snRNP binding uc009guw.1 uc009guw.2 uc009guw.3 uc009guw.4 
ENSMUST00000074606.11 Cd302 ENSMUST00000074606.11 CD302 antigen, transcript variant 1 (from RefSeq NM_001290660.1) A2AW84 A2AW85 CD302_MOUSE Clec13a ENSMUST00000074606.1 ENSMUST00000074606.10 ENSMUST00000074606.2 ENSMUST00000074606.3 ENSMUST00000074606.4 ENSMUST00000074606.5 ENSMUST00000074606.6 ENSMUST00000074606.7 ENSMUST00000074606.8 ENSMUST00000074606.9 NM_001290660 Q78KD8 Q9D0X7 Q9DCG2 uc008juc.1 uc008juc.2 uc008juc.3 uc008juc.4 Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration. Membrane ; Single-pass type I membrane protein Cell projection, filopodium Cytoplasm, cell cortex Cell projection, microvillus Note=Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DCG2-1; Sequence=Displayed; Name=2; IsoId=Q9DCG2-2; Sequence=VSP_020910; transmembrane signaling receptor activity cytoplasm microvillus cell cortex phagocytosis membrane integral component of membrane filopodium carbohydrate binding cell projection uc008juc.1 uc008juc.2 uc008juc.3 uc008juc.4 
ENSMUST00000074608.4 Ndufb11b ENSMUST00000074608.4 NADH:ubiquinone oxidoreductase subunit B11B (from RefSeq NM_025503.4) 1700029P11Rik ENSMUST00000074608.1 ENSMUST00000074608.2 ENSMUST00000074608.3 NM_025503 Ndufb11b Q9CQ68 Q9CQ68_MOUSE uc007wxv.1 uc007wxv.2 uc007wxv.3 uc007wxv.4 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Membrane ; Single- pass membrane protein Belongs to the complex I NDUFB11 subunit family. molecular_function mitochondrion mitochondrial respiratory chain complex I biological_process membrane integral component of membrane uc007wxv.1 uc007wxv.2 uc007wxv.3 uc007wxv.4 
ENSMUST00000074613.4 Acyp2 ENSMUST00000074613.4 acylphosphatase 2, muscle type (from RefSeq NM_029344.4) ACYP2_MOUSE Acyp ENSMUST00000074613.1 ENSMUST00000074613.2 ENSMUST00000074613.3 NM_029344 P56375 Q5SPV7 Q8BQX2 uc007ihw.1 uc007ihw.2 uc007ihw.3 Reaction=an acyl phosphate + H2O = a carboxylate + H(+) + phosphate; Xref=Rhea:RHEA:14965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:43474, ChEBI:CHEBI:59918; EC=3.6.1.7; Belongs to the acylphosphatase family. Sequence=AAH27642.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; acylphosphatase activity mitochondrion biological_process hydrolase activity identical protein binding uc007ihw.1 uc007ihw.2 uc007ihw.3 
ENSMUST00000074615.7 Atg5lrt ENSMUST00000074615.7 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. (from UniProt J3QNM7) Atg5lrt ENSMUST00000074615.1 ENSMUST00000074615.2 ENSMUST00000074615.3 ENSMUST00000074615.4 ENSMUST00000074615.5 ENSMUST00000074615.6 Gm5426 J3QNM7 J3QNM7_MOUSE uc287ujc.1 uc287ujc.2 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane. Membrane Mitochondrion Belongs to the ATPase g subunit family. mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) mitochondrion ATP biosynthetic process ion transport hydrogen ion transmembrane transporter activity ATP synthesis coupled proton transport membrane proton-transporting ATP synthase complex, coupling factor F(o) proton-transporting ATP synthase activity, rotational mechanism uc287ujc.1 uc287ujc.2 
ENSMUST00000074616.7 Srek1 ENSMUST00000074616.7 splicing regulatory glutamine/lysine-rich protein 1, transcript variant 7 (from RefSeq NR_189738.1) ENSMUST00000074616.1 ENSMUST00000074616.2 ENSMUST00000074616.3 ENSMUST00000074616.4 ENSMUST00000074616.5 ENSMUST00000074616.6 NR_189738 Q8BLM8 Q8BWK7 Q8BYK0 Q8BYZ4 Q8BZX4 SREK1_MOUSE Sfrs12 Srrp86 uc007rsj.1 uc007rsj.2 uc007rsj.3 Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). Homodimer. Binds SFRS1, SFRS2, SFRS3 and SFRS6. Interacts with the spliceosome. Interacts with SREK1IP1 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZX4-1; Sequence=Displayed; Name=2; IsoId=Q8BZX4-2; Sequence=VSP_008400; Belongs to the splicing factor SR family. regulation of alternative mRNA splicing, via spliceosome nucleic acid binding nucleus nucleoplasm spliceosomal complex mRNA processing biological_process RNA splicing nuclear speck uc007rsj.1 uc007rsj.2 uc007rsj.3 
ENSMUST00000074618.10 Nfatc2 ENSMUST00000074618.10 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2, transcript variant 1 (from RefSeq NM_010899.3) A2APK2 A2APK3 A2AQC5 A2AQC6 A2AQC7 B5B2Q3 ENSMUST00000074618.1 ENSMUST00000074618.2 ENSMUST00000074618.3 ENSMUST00000074618.4 ENSMUST00000074618.5 ENSMUST00000074618.6 ENSMUST00000074618.7 ENSMUST00000074618.8 ENSMUST00000074618.9 NFAC2_MOUSE NM_010899 Nfat1 Nfatp Q60591 Q60984 Q60985 Q91Y65 uc008oau.1 uc008oau.2 uc008oau.3 uc008oau.4 Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (By similarity). Is involved in the negative regulation of chondrogenesis (PubMed:10620601). Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. The phosphorylated form specifically interacts with XPO1; which mediates nuclear export. NFATC proteins bind to DNA as monomers. Interacts with NFATC2IP. Interacts with FOXP3 (By similarity). Interacts with TBX21 ('Thr-302' phosphorylated form) (PubMed:23616576). Interacts with KAT2A (PubMed:28424240). Interacts with HOMER2 and HOMER3; this interaction competes with calcineurin/PPP3CA-binding and hence prevents NFATC2 dephosphorylation and activation (By similarity). Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Q60591; Q86Y07-1: VRK2; Xeno; NbExp=2; IntAct=EBI-643104, EBI-1207633; Cytoplasm Nucleus Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin- mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. Event=Alternative splicing; Named isoforms=4; Name=C; IsoId=Q60591-3; Sequence=Displayed; Name=B; IsoId=Q60591-2; Sequence=VSP_005596; Name=D; IsoId=Q60591-4; Sequence=VSP_005597; Name=A; IsoId=Q60591-1; Sequence=Not described; Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas (PubMed:18675896). Expressed in cartilage (PubMed:10620601). Expressed in the developing heart at 13.5 and 16.5 dpc, during the transition from spongy to compact myocardium (PubMed:17198697). Not detected in the skeletal system at 11 and 13.5 dpc (PubMed:10620601). Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors. In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-365 region. Upon cell stimulation, all these sites except Ser-245 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, one site among Ser-53; Ser-54 and Ser-56 is phosphorylated; which is required for full transcriptional activity. Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome. NFATC2-knocked down adult animals develop progressive difficulty in ambulation, fixed joint contractures and reduced joint motion, associated with joint destruction and the formation of ectopic cartilage and bone masses. Skeletal morphogenesis is normal during embryonic development. Cartilage cells from NFATC2- knocked down mice display uncontrolled growth consistent with malignant transformation. [Isoform A]: PubMed:8668213 (AAC52929) sequence is a chimeric cDNA. Sequence=AAC52929.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA fused with Phyhd1 (Lrrc8a).; Evidence=; negative regulation of transcription from RNA polymerase II promoter nuclear chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cytokine production DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated cellular response to DNA damage stimulus transcription factor binding positive regulation of gene expression myotube cell development cell migration phosphatase binding positive regulation of B cell proliferation calcineurin-NFAT signaling cascade response to drug sequence-specific DNA binding transcription regulatory region DNA binding nuclear transcription factor complex positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter B cell receptor signaling pathway positive regulation of myoblast fusion negative regulation of vascular smooth muscle cell differentiation ribonucleoprotein complex uc008oau.1 uc008oau.2 uc008oau.3 uc008oau.4 
ENSMUST00000074622.11 Brinp3 ENSMUST00000074622.11 bone morphogenetic protein/retinoic acid inducible neural specific 3, transcript variant 1 (from RefSeq NM_153539.3) BRNP3_MOUSE ENSMUST00000074622.1 ENSMUST00000074622.10 ENSMUST00000074622.2 ENSMUST00000074622.3 ENSMUST00000074622.4 ENSMUST00000074622.5 ENSMUST00000074622.6 ENSMUST00000074622.7 ENSMUST00000074622.8 ENSMUST00000074622.9 Fam5c NM_153539 Q499E0 Q8K0R9 uc007cxo.1 uc007cxo.2 uc007cxo.3 uc007cxo.4 Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development. Secreted Mitochondrion Expressed in the brain. Weakly expressed in embryonic stem (ES) cells. Expressed in ES-derived neural stem cells (NSCs) and neuronal cells. Up-regulated upon differentiation into neuronal cells in the presence of retinoic acid and BDNF. Down-regulated upon differentiation into astroglial cells. Down-regulated in gonadotrope cells by bone morphogenetic protein and retinoic acid. Belongs to the BRINP family. molecular_function extracellular region mitochondrion endoplasmic reticulum cell cycle cell cycle arrest nervous system development dendrite neuronal cell body positive regulation of neuron differentiation negative regulation of cell cycle negative regulation of mitotic cell cycle cellular response to retinoic acid uc007cxo.1 uc007cxo.2 uc007cxo.3 uc007cxo.4 
ENSMUST00000074628.13 Wbp2 ENSMUST00000074628.13 WW domain binding protein 2, transcript variant 1 (from RefSeq NM_016852.3) ENSMUST00000074628.1 ENSMUST00000074628.10 ENSMUST00000074628.11 ENSMUST00000074628.12 ENSMUST00000074628.2 ENSMUST00000074628.3 ENSMUST00000074628.4 ENSMUST00000074628.5 ENSMUST00000074628.6 ENSMUST00000074628.7 ENSMUST00000074628.8 ENSMUST00000074628.9 NM_016852 Q544A1 Q544A1_MOUSE Wbp2 uc007mjv.1 uc007mjv.2 uc007mjv.3 nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription coactivator activity nucleus cytoplasm estrogen receptor binding chromatin DNA binding response to progesterone positive regulation of intracellular estrogen receptor signaling pathway response to estrogen establishment of protein localization positive regulation of gene expression, epigenetic positive regulation of transcription from RNA polymerase II promoter progesterone receptor signaling pathway cellular response to estrogen stimulus positive regulation of histone H3-K14 acetylation uc007mjv.1 uc007mjv.2 uc007mjv.3 
ENSMUST00000074637.4 Krtap6-5 ENSMUST00000074637.4 keratin associated protein 6-5 (from RefSeq NM_130856.2) ENSMUST00000074637.1 ENSMUST00000074637.2 ENSMUST00000074637.3 KRA65_MOUSE Krtap16-8 Krtap16.8 NM_130856 Q925H3 uc012ahz.1 uc012ahz.2 uc012ahz.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Strong expression in narrowly defined pattern restricted to the lower and middle cortical regions of the hair shaft in both developing and cycling hair. During hair follicle regression (catagen), expression levels decrease until expression is no longer detectable in follicles at resting stage (telogen). Expression in skin and hair follicle is regulated by HOXC13 and by GATA3. Belongs to the KRTAP type 6 family. molecular_function cellular_component intermediate filament biological_process keratinization uc012ahz.1 uc012ahz.2 uc012ahz.3 
ENSMUST00000074653.6 Ark2n ENSMUST00000074653.6 arkadia (RNF111) N-terminal like PKA signaling regulator 2N, transcript variant 1 (from RefSeq NM_178670.4) 8030462N17Rik Ark2n ENSMUST00000074653.1 ENSMUST00000074653.2 ENSMUST00000074653.3 ENSMUST00000074653.4 ENSMUST00000074653.5 NM_178670 Q0VAW6 Q0VAW6_MOUSE uc008frn.1 uc008frn.2 uc008frn.3 Nucleus uc008frn.1 uc008frn.2 uc008frn.3 
ENSMUST00000074667.9 T ENSMUST00000074667.9 brachyury, T-box transcription factor T (from RefSeq NM_009309.2) ENSMUST00000074667.1 ENSMUST00000074667.2 ENSMUST00000074667.3 ENSMUST00000074667.4 ENSMUST00000074667.5 ENSMUST00000074667.6 ENSMUST00000074667.7 ENSMUST00000074667.8 NM_009309 Q78ZW9 Q78ZW9_MOUSE T brachyury(T) uc008ajq.1 uc008ajq.2 Nucleus Lacks conserved residue(s) required for the propagation of feature annotation. nuclear chromatin RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II activating transcription factor binding heart morphogenesis positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated cellular response to retinoic acid uc008ajq.1 uc008ajq.2 
ENSMUST00000074690.11 Ubxn11 ENSMUST00000074690.11 UBX domain protein 11, transcript variant 1 (from RefSeq NM_026257.3) D4Bwg1540e ENSMUST00000074690.1 ENSMUST00000074690.10 ENSMUST00000074690.2 ENSMUST00000074690.3 ENSMUST00000074690.4 ENSMUST00000074690.5 ENSMUST00000074690.6 ENSMUST00000074690.7 ENSMUST00000074690.8 ENSMUST00000074690.9 NM_026257 Q8C843 Q8VCP5 Q9CWP0 Q9D572 Soc UBX11_MOUSE Ubxd5 uc008veb.1 uc008veb.2 uc008veb.3 uc008veb.4 May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity). Interacts with GNA12, GNA13, RND1, RND2 and RND3. Cytoplasm, cytoskeleton Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D572-1; Sequence=Displayed; Name=2; IsoId=Q9D572-2; Sequence=VSP_024778, VSP_024779; Sequence=BAB26982.1; Type=Frameshift; Evidence=; Sequence=BAC33351.1; Type=Frameshift; Evidence=; cellular_component cytoplasm cytoskeleton ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process uc008veb.1 uc008veb.2 uc008veb.3 uc008veb.4 
ENSMUST00000074693.13 Serpina11 ENSMUST00000074693.13 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11, transcript variant 1 (from RefSeq NM_199314.2) E9QLL8 E9QLL8_MOUSE ENSMUST00000074693.1 ENSMUST00000074693.10 ENSMUST00000074693.11 ENSMUST00000074693.12 ENSMUST00000074693.2 ENSMUST00000074693.3 ENSMUST00000074693.4 ENSMUST00000074693.5 ENSMUST00000074693.6 ENSMUST00000074693.7 ENSMUST00000074693.8 ENSMUST00000074693.9 NM_199314 Serpina11 uc007owm.1 uc007owm.2 uc007owm.3 uc007owm.4 Belongs to the serpin family. extracellular space uc007owm.1 uc007owm.2 uc007owm.3 uc007owm.4 
ENSMUST00000074694.7 Gnai1 ENSMUST00000074694.7 G protein subunit alpha i1 (from RefSeq NM_010305.1) B2RSH2 ENSMUST00000074694.1 ENSMUST00000074694.2 ENSMUST00000074694.3 ENSMUST00000074694.4 ENSMUST00000074694.5 ENSMUST00000074694.6 GNAI1_MOUSE Gnai-1 NM_010305 uc008wns.1 uc008wns.2 uc008wns.3 Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis. Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Part of a spindle orientation complex at least composed of GNAI1, GPSM2 and NUMA1. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG1. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG2. GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins (By similarity). Interacts (GDP-bound form) with GPSM1; this inhibits guanine nucleotide exchange and GTP binding (By similarity). Interacts (GDP-bound form) with GPSM2 (via GoLoco domains); this inhibits guanine nucleotide exchange. Interacts with RGS10; this strongly enhances GTP hydrolysis. Interacts with RGS1 and RGS16; this strongly enhances GTPase activity. Interacts with RGS4. Interacts with RGS12. Interacts (via active GTP- or inactive GDP-bound forms) with RGS14 (via RGS and GoLoco domains). Interacts with RGS3, RGS6, RGS7, RGS8, RGS17, RGS18 and RGS20 (in vitro) (By similarity). Interacts (GDP-bound form) with RIC8A (via C-terminus) (By similarity). Interacts (inactive GDP-bound form) with NUCB1 (via GBA motif); the interaction leads to activation of GNAI1 (By similarity). Interacts (inactive GDP-bound form) with CCDC88C/DAPLE (via GBA motif); the interaction leads to activation of GNAI1 (By similarity). Interacts (inactive GDP-bound form) with CCDC8A/GIV (via GBA motif) (By similarity). Nucleus Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cell cortex Membrane ; Lipid-anchor Note=Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane. Myristoylation at Gly-2 is required for membrane anchoring before palmitoylation. Palmitoylation at Cys-3 varies with membrane lipid composition. Belongs to the G-alpha family. G(i/o/t/z) subfamily. nucleotide binding magnesium ion binding G-protein coupled receptor binding GTPase activity protein binding GTP binding nucleus nucleolus cytoplasm centrosome microtubule organizing center heterotrimeric G-protein complex cytoskeleton plasma membrane cell cortex cell cycle signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway membrane guanyl nucleotide binding GDP binding midbody G-protein beta/gamma-subunit complex binding G-protein coupled serotonin receptor binding GTPase activating protein binding macromolecular complex regulation of cAMP-mediated signaling membrane raft metal ion binding negative regulation of synaptic transmission cell division regulation of mitotic spindle organization cell cortex region cellular response to forskolin positive regulation of protein localization to cell cortex uc008wns.1 uc008wns.2 uc008wns.3 
ENSMUST00000074700.9 Mup2 ENSMUST00000074700.9 major urinary protein 2, transcript variant 1 (from RefSeq NM_008647.4) A2AKN9 A2AKN9_MOUSE ENSMUST00000074700.1 ENSMUST00000074700.2 ENSMUST00000074700.3 ENSMUST00000074700.4 ENSMUST00000074700.5 ENSMUST00000074700.6 ENSMUST00000074700.7 ENSMUST00000074700.8 Mup2 Mup4 NM_008647 uc008taj.1 uc008taj.2 uc008taj.3 uc008taj.4 uc008taj.5 uc008taj.6 Secreted Belongs to the calycin superfamily. Lipocalin family. small molecule binding uc008taj.1 uc008taj.2 uc008taj.3 uc008taj.4 uc008taj.5 uc008taj.6 
ENSMUST00000074729.6 Dgkh ENSMUST00000074729.6 Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:27643686). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (By similarity). (from UniProt D3YXJ0) A0A0B5JC35 BC117904 D3YXJ0 DGKH_MOUSE Dgkh ENSMUST00000074729.1 ENSMUST00000074729.2 ENSMUST00000074729.3 ENSMUST00000074729.4 ENSMUST00000074729.5 uc007uso.1 uc007uso.2 Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:27643686). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (By similarity). Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10273; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328; Evidence=; Lipid metabolism; glycerolipid metabolism. Interacts with RAF1 and BRAF. [Isoform 1]: Homooligomers. Heterooligomers. Oligomerization through the SAM domain inhibits the diacylglycerol kinase activity. Heterooligomerizes with SAM domain-containing isoforms of DGKD. [Isoform 2]: Does not form homooligomers. Cytoplasm Cell membrane Cytoplasm, cytoskeleton Note=Translocated from the cytoplasm to endosomes in response to stress stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=DAG kinase eta-2 ; IsoId=D3YXJ0-1; Sequence=Displayed; Name=2; Synonyms=DAG kinase eta-1 ; IsoId=D3YXJ0-2; Sequence=VSP_060669, VSP_060670; Name=3; Synonyms=DAG kinase eta-3 ; IsoId=D3YXJ0-3; Sequence=VSP_060668, VSP_060669, VSP_060670; Widely expressed (PubMed:27643686). Detected in the granulosa cells of the primary and secondary follicles (PubMed:25613821). Expressed in mature follicles and corpus lutea (PubMed:25613821). Expressed in the oviductal epithelium (PubMed:25613821). In the uterus, strongly expressed in the luminal epithelium (PubMed:25613821). Detected in the uterine glands (PubMed:25613821). [Isoform 2]: Detected in ovary and uterus (at protein level). [Isoform 3]: Specifically expressed in testis (PubMed:25613821, PubMed:27643686). Detected in the inner area of the testis (PubMed:25613821). Strongly expressed in the secondary spermatocytes and the round spermatids and weakly detected in the primary spermatocytes (PubMed:25613821). The SAM domain mediates homooligomerization. Phosphorylated. Phosphorylation does not inhibit catalytic activity. Belongs to the eukaryotic diacylglycerol kinase family. nucleotide binding NAD+ kinase activity diacylglycerol kinase activity ATP binding cytoplasm endosome signal transduction protein kinase C-activating G-protein coupled receptor signaling pathway kinase activity phosphorylation transferase activity intracellular signal transduction protein homodimerization activity diacylglycerol metabolic process phosphatidic acid metabolic process glycerolipid metabolic process lipid phosphorylation protein oligomerization uc007uso.1 uc007uso.2 
ENSMUST00000074733.11 Septin11 ENSMUST00000074733.11 septin 11, transcript variant 3 (from RefSeq NM_001009818.2) D5Ertd606e ENSMUST00000074733.1 ENSMUST00000074733.10 ENSMUST00000074733.2 ENSMUST00000074733.3 ENSMUST00000074733.4 ENSMUST00000074733.5 ENSMUST00000074733.6 ENSMUST00000074733.7 ENSMUST00000074733.8 ENSMUST00000074733.9 NM_001009818 Q3TBA0 Q3TC24 Q5D0F0 Q6P2K5 Q6P6I0 Q8C1B7 SEP11_MOUSE Sept11 Septin11 uc008ydy.1 uc008ydy.2 uc008ydy.3 uc008ydy.4 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules (By similarity). Forms homooligomers (By similarity). GTPase activity is required for filament formation (By similarity). Interacts with SEPTIN7, SEPTIN9 and SEPTIN12 (By similarity). Cytoplasm Cytoplasm, cytoskeleton Synapse Cell projection, dendritic spine Cell projection, axon Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C1B7-1; Sequence=Displayed; Name=2; IsoId=Q8C1B7-2; Sequence=VSP_011041; Name=3; IsoId=Q8C1B7-3; Sequence=VSP_011042; Expressed in the cerebral cortex (at protein level). Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. nucleotide binding stress fiber GTPase activity protein binding GTP binding cytoplasm cytoskeleton septin ring cell cycle microtubule cytoskeleton cell junction axon septin complex cell projection dendritic spine synapse regulation of synapse organization protein heterooligomerization cell division cilium assembly cytoskeleton-dependent cytokinesis postsynapse glutamatergic synapse GABA-ergic synapse postsynaptic specialization of symmetric synapse uc008ydy.1 uc008ydy.2 uc008ydy.3 uc008ydy.4 
ENSMUST00000074740.5 Or8b53 ENSMUST00000074740.5 olfactory receptor family 8 subfamily B member 53 (from RefSeq NM_146787.2) E9Q413 E9Q413_MOUSE ENSMUST00000074740.1 ENSMUST00000074740.2 ENSMUST00000074740.3 ENSMUST00000074740.4 NM_146787 Olfr920 Or8b53 uc009oxc.1 uc009oxc.2 uc009oxc.3 uc009oxc.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK039833.1, BB634349.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oxc.1 uc009oxc.2 uc009oxc.3 uc009oxc.4 
ENSMUST00000074752.4 H2ac15 ENSMUST00000074752.4 H2A clustered histone 15 (from RefSeq NM_178183.2) ENSMUST00000074752.1 ENSMUST00000074752.2 ENSMUST00000074752.3 H2A1K_MOUSE H2ac15 Hist1h2ak NM_178183 Q0VE75 Q8CGP7 uc007prg.1 uc007prg.2 uc007prg.3 uc007prg.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007prg.1 uc007prg.2 uc007prg.3 uc007prg.4 
ENSMUST00000074783.12 Hmcn1 ENSMUST00000074783.12 hemicentin 1 (from RefSeq NM_001024720.3) D3YXG0 D3Z2Q7 ENSMUST00000074783.1 ENSMUST00000074783.10 ENSMUST00000074783.11 ENSMUST00000074783.2 ENSMUST00000074783.3 ENSMUST00000074783.4 ENSMUST00000074783.5 ENSMUST00000074783.6 ENSMUST00000074783.7 ENSMUST00000074783.8 ENSMUST00000074783.9 HMCN1_MOUSE Hmcn1 NM_001024720 uc007cyj.1 uc007cyj.2 uc007cyj.3 uc007cyj.4 Involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibers and broadening, flattening and elongation of podocytes (By similarity). Plays a role in basement membrane organization (PubMed:34504132). May promote cleavage furrow maturation during cytokinesis in preimplantation embryos (PubMed:21215633). May play a role in the architecture of adhesive and flexible epithelial cell junctions (PubMed:17015624). May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration (PubMed:24951538). Secreted, extracellular space, extracellular matrix, basement membrane toplasm Cell junction Cleavage furrow Note=Has been detected in the glomerular basement membrane in one study (PubMed:29488390). However, another study found expression in the glomerular mesangial matrix but not in the glomerular basement membrane (PubMed:32035013). The antibody used in PubMed:17015624 and PubMed:21215633 to determine subcellular location does not distinguish between HMCN1 and HMCN2 (PubMed:17015624, PubMed:21215633). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=D3YXG0-1; Sequence=Displayed; Name=2; IsoId=D3YXG0-2; Sequence=VSP_058526; In the kidney, expressed in the glomerulus (at protein level) (PubMed:29488390, PubMed:32035013). Expressed in whisker and hair follicles, eye, tongue, and splenic and lymph node conduits (at protein level) (PubMed:32035013). In the embryo, localizes to the cleavage furrow at the two-cell stage (at protein level) (PubMed:34504132). In neonatal skin, expressed throughout the dermis (at protein level) (PubMed:34504132). In adult skin, strongly concentrated at the dermal side of the basement membrane but not detectable in the deeper dermis (PubMed:34504132). Shows tendon- specific localization at the myotendinous junction and is also detected in the perichondrium (at protein level) (PubMed:34504132). Expressed by chondrocytes residing in articular cartilage and the femoral growth plate of 52 week old mice (at protein level) (PubMed:34504132). Expressed in vascular endothelial cells in coronary arteries and sparsely in endocardial endothelium (at protein level) (PubMed:24951538). Expressed in skin, tongue, lung and eye (PubMed:17015624). At 14.5 dpc, expressed in the vibrissae, dermis, forelimb, kidney, intestine, lung and iliac cartilage where expression is found mainly in mesenchymal cells (PubMed:34504132). Expression increases with age from 3 weeks to 15- 20 weeks (at protein level). Induced by high glucose and transforming growth factor beta (at protein level) (PubMed:29488390). Following wounding, up-regulated in the dermis adjacent to the epidermal tongues of closing wounds (at protein level) (PubMed:34504132). Up-regulated following myocardial infarction. Mutants are viable and fertile with no gross phenotypes (PubMed:32035013, PubMed:34504132). Ultrastructural basement membrane alterations are observed at dermal-epidermal and myotendinous junctions (PubMed:34504132). However, another study showed that embryos arrest between the one- and four-cell stages with cleavage furrows that form but fail to ingress and often retract prior to completion, resulting in multinucleate cells (PubMed:21215633). Double knockout of Hmcn1 and Hmcn2 results in no overt phenotypes with mice being viable and fertile (PubMed:32035013). Has been shown in one study to play a role in cleavage furrow maturation during cytokinesis (PubMed:21215633). However, other studies have shown no role in this process (PubMed:32035013, PubMed:34504132). extracellular matrix structural constituent calcium ion binding extracellular region basement membrane cytoplasm cell-cell adherens junction cell cortex cell cycle homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules response to bacterium cell junction cleavage furrow signaling receptor activity protein homodimerization activity cell adhesion molecule binding cell division uc007cyj.1 uc007cyj.2 uc007cyj.3 uc007cyj.4 
ENSMUST00000074792.7 Mtfmt ENSMUST00000074792.7 mitochondrial methionyl-tRNA formyltransferase (from RefSeq NM_027134.3) E9QKZ0 ENSMUST00000074792.1 ENSMUST00000074792.2 ENSMUST00000074792.3 ENSMUST00000074792.4 ENSMUST00000074792.5 ENSMUST00000074792.6 FMT_MOUSE Fmt NM_027134 Q8VE89 Q9D799 uc009qdh.1 uc009qdh.2 uc009qdh.3 Methionyl-tRNA formyltransferase that formylates methionyl- tRNA in mitochondria and is crucial for translation initiation. Reaction=(6R)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl- tRNA(fMet); Xref=Rhea:RHEA:24380, Rhea:RHEA-COMP:9952, Rhea:RHEA- COMP:9953, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453, ChEBI:CHEBI:78530, ChEBI:CHEBI:78844, ChEBI:CHEBI:195366; EC=2.1.2.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24381; Evidence=; Mitochondrion Composed of an N- and a C-terminal domain. The N-terminal domain carries the tetrahydrofolate (THF)-binding site and the C- terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylation reaction. Belongs to the Fmt family. methionyl-tRNA formyltransferase activity mitochondrion translation translational initiation biosynthetic process transferase activity hydroxymethyl-, formyl- and related transferase activity conversion of methionyl-tRNA to N-formyl-methionyl-tRNA uc009qdh.1 uc009qdh.2 uc009qdh.3 
ENSMUST00000074806.12 H2-Q2 ENSMUST00000074806.12 histocompatibility 2, Q region locus 2, transcript variant 1 (from RefSeq NM_010392.3) ENSMUST00000074806.1 ENSMUST00000074806.10 ENSMUST00000074806.11 ENSMUST00000074806.2 ENSMUST00000074806.3 ENSMUST00000074806.4 ENSMUST00000074806.5 ENSMUST00000074806.6 ENSMUST00000074806.7 ENSMUST00000074806.8 ENSMUST00000074806.9 Gm11132 H2-Q2 NM_010392 Q4KN81 Q4KN81_MOUSE uc008chl.1 uc008chl.2 uc008chl.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response female pregnancy external side of plasma membrane cell surface membrane integral component of membrane antigen processing and presentation beta-2-microglobulin binding multicellular organism growth peptide binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex TAP binding protein heterodimerization activity endoplasmic reticulum exit site uc008chl.1 uc008chl.2 uc008chl.3 
ENSMUST00000074807.8 Lrig3 ENSMUST00000074807.8 leucine-rich repeats and immunoglobulin-like domains 3 (from RefSeq NM_177152.5) ENSMUST00000074807.1 ENSMUST00000074807.2 ENSMUST00000074807.3 ENSMUST00000074807.4 ENSMUST00000074807.5 ENSMUST00000074807.6 ENSMUST00000074807.7 Kiaa3016 LRIG3_MOUSE NM_177152 Q6P1C6 Q6ZPE6 Q8BRF0 Q8BS51 Q8C5E4 uc007hhd.1 uc007hhd.2 uc007hhd.3 uc007hhd.4 Plays a role in craniofacial and inner ear morphogenesis during embryonic development. Acts within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1. Interacts with EGFR, ERBB2 and ERBB4 (in vitro). Cell membrane ; Single-pass type I membrane protein Cytoplasmic vesicle membrane ; Single-pass type I membrane protein Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4. Widely expressed. Detected in the lateral wall of the otic vesicle at 10.5 dpc. Enriched in lateral pouch epithelium at 12.5 dpc. Mice display circling and head tossing behavior, due to a defect in inner ear morphogenesis. In mutants, fusion of the canal pouches starts earlier than normal and involves an abnormally large region, leading to truncation of the lateral semicircular canal in the inner ear. Nevertheless, hearing seems to be normal. Mutant mice also display craniofacial deformities, and especially a dramatically shortened snout. Sequence=BAC32175.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC98291.1; Type=Frameshift; Evidence=; plasma membrane multicellular organism development membrane integral component of membrane cytoplasmic vesicle membrane cytoplasmic vesicle otolith morphogenesis uc007hhd.1 uc007hhd.2 uc007hhd.3 uc007hhd.4 
ENSMUST00000074829.4 Tlr12 ENSMUST00000074829.4 toll-like receptor 12 (from RefSeq NM_205823.2) ENSMUST00000074829.1 ENSMUST00000074829.2 ENSMUST00000074829.3 Gm1365 NM_205823 Q6QNU9 TLR12_MOUSE Tlr11 Tlr12 uc008uvf.1 uc008uvf.2 uc008uvf.3 Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in preventing infection of internal organs of the urogenital system. Binds MYD88 via their respective TIR domains. Membrane ; Single-pass type I membrane protein Macrophages, liver, kidney and bladder epithelial cells. Has increased susceptibility to the uropathogenic E.coli strain 8NU. Following infection, kidneys show a significantly increased bacterial load and increased inflammatory response, whereas bladder shows a similar response to wild type. Belongs to the Toll-like receptor family. There is some confusion regarding the nomenclature of this gene. In the literature, Tlr12 is frequently referred to as Tlr11 and vice-versa. In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity. toll-like receptor signaling pathway immune system process integral component of plasma membrane inflammatory response signal transduction membrane integral component of membrane defense response to protozoan innate immune response uc008uvf.1 uc008uvf.2 uc008uvf.3 
ENSMUST00000074839.7 Ear2 ENSMUST00000074839.7 eosinophil-associated, ribonuclease A family, member 2 (from RefSeq NM_007895.2) ENSMUST00000074839.1 ENSMUST00000074839.2 ENSMUST00000074839.3 ENSMUST00000074839.4 ENSMUST00000074839.5 ENSMUST00000074839.6 Ear2 NM_007895 Raf3 W0UVF7 W0UVF7_MOUSE uc007tdi.1 uc007tdi.2 uc007tdi.3 Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity hydrolase activity nucleic acid phosphodiester bond hydrolysis uc007tdi.1 uc007tdi.2 uc007tdi.3 
ENSMUST00000074840.12 Preb ENSMUST00000074840.12 prolactin regulatory element binding, transcript variant 5 (from RefSeq NR_185491.1) ENSMUST00000074840.1 ENSMUST00000074840.10 ENSMUST00000074840.11 ENSMUST00000074840.2 ENSMUST00000074840.3 ENSMUST00000074840.4 ENSMUST00000074840.5 ENSMUST00000074840.6 ENSMUST00000074840.7 ENSMUST00000074840.8 ENSMUST00000074840.9 NR_185491 PREB_MOUSE Q9QZ99 Q9WUQ2 Sec12 uc012dui.1 uc012dui.2 uc012dui.3 uc012dui.4 Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. Interacts with SAR1B (GDP-bound form) (PubMed:11422940). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites (By similarity). Interacts with CIDEB; facilitating loading of SCAP- SREBP into COPII vesicles (PubMed:30858281). Endoplasmic reticulum membrane ; Single-pass membrane protein Nucleus Note=Concentrates at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Detected starting at 10.5 dpc in the ectoderm and superficial mesoderm surrounding the caudal part of the tail region. At 12.5 dpc detected in dorsal root ganglia, surface ectoderm surrounding the caudal part of the tail, the inferior wall of the genital tubercle, developing liver, in Rathke pouch and in condensing mesenchyme forming the roof of the skull. At 14.5 dpc detected in the perichondrial region of the craniofacial, axial, and appendicular skeleton. By 16.5 dpc expression is much lower throughout the embryo, and is not detectable by 18.5 dpc. Golgi membrane transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding regulation of COPII vesicle coating DNA binding transcription factor activity, sequence-specific DNA binding Sar guanyl-nucleotide exchange factor activity GTPase activator activity nucleus endoplasmic reticulum endoplasmic reticulum membrane regulation of transcription, DNA-templated ER to Golgi vesicle-mediated transport protein secretion protein transport membrane integral component of membrane vesicle-mediated transport integral component of endoplasmic reticulum membrane protein exit from endoplasmic reticulum positive regulation of GTPase activity positive regulation of transcription from RNA polymerase II promoter COPII vesicle coating regulation of catalytic activity GTPase binding endoplasmic reticulum exit site ARF guanyl-nucleotide exchange factor activity Rab guanyl-nucleotide exchange factor activity uc012dui.1 uc012dui.2 uc012dui.3 uc012dui.4 
ENSMUST00000074861.9 Plac1 ENSMUST00000074861.9 placental specific protein 1, transcript variant 2 (from RefSeq NM_001357802.2) ENSMUST00000074861.1 ENSMUST00000074861.2 ENSMUST00000074861.3 ENSMUST00000074861.4 ENSMUST00000074861.5 ENSMUST00000074861.6 ENSMUST00000074861.7 ENSMUST00000074861.8 NM_001357802 PLAC1_MOUSE Plac1 Q3UKT4 Q80WW3 Q9JI83 uc009teu.1 uc009teu.2 uc009teu.3 May play a role in placental development. Secreted Expressed in placenta. Strongly expressed at 7 dpc and gradually declines with the progression of embryogenesis. Expression detected from 7.5 to 14.5 dpc in ectoplacental cone, trophoblast giant cells, and labyrinthine trophoblasts. Belongs to the PLAC1 family. placenta development molecular_function cellular_component extracellular region multicellular organism development spongiotrophoblast layer developmental growth uc009teu.1 uc009teu.2 uc009teu.3 
ENSMUST00000074880.6 Gfral ENSMUST00000074880.6 GDNF family receptor alpha like, transcript variant 1 (from RefSeq NM_205844.4) ENSMUST00000074880.1 ENSMUST00000074880.2 ENSMUST00000074880.3 ENSMUST00000074880.4 ENSMUST00000074880.5 GFRAL_MOUSE Gral NM_205844 Q6SJD9 Q6SJE0 uc009qsy.1 uc009qsy.2 Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846099, PubMed:28846097, PubMed:28846098). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways (PubMed:28846098, PubMed:28846099). Interacts (via the extracellular domain) with GDF15 and RET; receptor of GDF15, mediates cellular signaling through interaction with RET after GDF15-binding (PubMed:28846098, PubMed:28846099). Interaction with RET requires previous GDF15-binding (PubMed:28846099). Cell membrane ; Single-pass membrane protein ; Extracellular side Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=Q6SJE0-1; Sequence=Displayed; Name=B; IsoId=Q6SJE0-2; Sequence=VSP_019295, VSP_019296; Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius. On a chow diet, mutants show no difference in food intake, energy expenditure or body weight compare to wild-type controls. On high-fat diet, they gain substantially more weight and are more glucose intolerant. Diet-induced obese mutants are hyperphagic and have 32% greater total mass and 9% greater lean mass than diet-induced obese wild-type mice (PubMed:28953886, PubMed:28846097, PubMed:28846099). Upon chronical administration of GDF15, mutants are refractory to the GDF15 effects in comparison to wild-types that show attenuated food-intake and sustained weightloss (PubMed:28846098, PubMed:28953886, PubMed:28846097, PubMed:28846099). Belongs to the GDNFR family. activation of MAPK activity reduction of food intake in response to dietary excess protein binding plasma membrane nervous system development external side of plasma membrane membrane integral component of membrane glial cell-derived neurotrophic factor receptor activity receptor tyrosine kinase binding stress-activated protein kinase signaling cascade glial cell-derived neurotrophic factor receptor signaling pathway signaling receptor activity receptor complex positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of protein kinase B signaling negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc009qsy.1 uc009qsy.2 
ENSMUST00000074894.3 Gm6812 ENSMUST00000074894.3 predicted gene 6812 (from RefSeq NR_177969.1) ENSMUST00000074894.1 ENSMUST00000074894.2 NR_177969 uc009tja.1 uc009tja.2 uc009tja.3 uc009tja.4 uc009tja.5 uc009tja.1 uc009tja.2 uc009tja.3 uc009tja.4 uc009tja.5 
ENSMUST00000074898.8 Hp ENSMUST00000074898.8 haptoglobin, transcript variant 1 (from RefSeq NM_017370.2) ENSMUST00000074898.1 ENSMUST00000074898.2 ENSMUST00000074898.3 ENSMUST00000074898.4 ENSMUST00000074898.5 ENSMUST00000074898.6 ENSMUST00000074898.7 HPT_MOUSE NM_017370 Q61646 uc009nin.1 uc009nin.2 uc009nin.3 This gene encodes a plasma glycoprotein called haptoglobin that binds free hemoglobin. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta subunits that form a disulfide-linked tetrameric protein that plays an important role in the sequestration and clearance of extracorpuscular hemoglobin. Mice lacking the encoded protein exhibit stunted development of lymphoid organs associated with lower counts of mature T and B cells in the blood and secondary lymphoid compartments. [provided by RefSeq, Aug 2016]. As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity). Tetramer of two alpha and two beta chains; disulfide-linked (By similarity). The hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers (By similarity). Interacts with CD163 (By similarity). Interacts with ERGIC3 (By similarity). Secreted Expressed by the liver and secreted in plasma. The beta chain mediates most of the interactions with both subunits of hemoglobin, while the alpha chain forms the homodimeric interface. Belongs to the peptidase S1 family. Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity. liver development immune system process acute inflammatory response serine-type endopeptidase activity extracellular region extracellular space endoplasmic reticulum Golgi apparatus proteolysis acute-phase response Notch signaling pathway response to bacterium response to organic substance positive regulation of cell death antioxidant activity hemoglobin binding haptoglobin-hemoglobin complex response to hydrogen peroxide defense response to bacterium protein homodimerization activity negative regulation of oxidoreductase activity blood microparticle cellular oxidant detoxification negative regulation of hydrogen peroxide catabolic process uc009nin.1 uc009nin.2 uc009nin.3 
ENSMUST00000074912.8 Borcs7 ENSMUST00000074912.8 BLOC-1 related complex subunit 7 (from RefSeq NM_025563.3) BORC7_MOUSE Borcs7 ENSMUST00000074912.1 ENSMUST00000074912.2 ENSMUST00000074912.3 ENSMUST00000074912.4 ENSMUST00000074912.5 ENSMUST00000074912.6 ENSMUST00000074912.7 NM_025563 Q9CRC6 uc008hub.1 uc008hub.2 As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. Lysosome membrane Belongs to the BORCS7 family. molecular_function lysosome lysosomal membrane biological_process membrane BORC complex uc008hub.1 uc008hub.2 
ENSMUST00000074919.11 Wac ENSMUST00000074919.11 WW domain containing adaptor with coiled-coil, transcript variant 4 (from RefSeq NM_001360956.1) ENSMUST00000074919.1 ENSMUST00000074919.10 ENSMUST00000074919.2 ENSMUST00000074919.3 ENSMUST00000074919.4 ENSMUST00000074919.5 ENSMUST00000074919.6 ENSMUST00000074919.7 ENSMUST00000074919.8 ENSMUST00000074919.9 Kiaa1844 NM_001360956 Q3U0K1 Q66JM9 Q69Z92 Q8C2W2 Q8C8Q8 Q924H7 WAC_MOUSE uc008eab.1 uc008eab.2 uc008eab.3 uc008eab.4 uc008eab.5 Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway. Interacts (via coiled coil domain) with RNF20, RNF40 and UBE2A. Interacts (via WW domain) with RNA polymerase II. Interacts with MTOR and other components of the MTOR pathway including RPTOR, RUVBL1, RUVBL2, TTI1 and TTI2. Nucleus speckle Nucleus Note=In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q924H7-1; Sequence=Displayed; Name=2; IsoId=Q924H7-2; Sequence=VSP_021237; Name=3; IsoId=Q924H7-3; Sequence=VSP_021238; Phosphorylated on tyrosine residues. Sequence=BAD32552.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA polymerase II core binding chromatin binding nucleus nucleoplasm spliceosomal complex chromatin organization cellular response to DNA damage stimulus histone monoubiquitination positive regulation of macroautophagy nuclear speck negative regulation of proteasomal ubiquitin-dependent protein catabolic process G1 DNA damage checkpoint positive regulation of transcription, DNA-templated histone H2B conserved C-terminal lysine ubiquitination uc008eab.1 uc008eab.2 uc008eab.3 uc008eab.4 uc008eab.5 
ENSMUST00000074926.6 Krtap2-4 ENSMUST00000074926.6 keratin associated protein 2-4 (from RefSeq NM_027800.1) ENSMUST00000074926.1 ENSMUST00000074926.2 ENSMUST00000074926.3 ENSMUST00000074926.4 ENSMUST00000074926.5 Gm11937 Gm11938 Krtap2-4 NM_027800 Q9D3H4 Q9D3H4_MOUSE uc011yeq.1 uc011yeq.2 uc011yeq.3 molecular_function cellular_component biological_process keratin filament uc011yeq.1 uc011yeq.2 uc011yeq.3 
ENSMUST00000074936.10 Irak4 ENSMUST00000074936.10 interleukin-1 receptor-associated kinase 4 (from RefSeq NM_029926.5) ENSMUST00000074936.1 ENSMUST00000074936.2 ENSMUST00000074936.3 ENSMUST00000074936.4 ENSMUST00000074936.5 ENSMUST00000074936.6 ENSMUST00000074936.7 ENSMUST00000074936.8 ENSMUST00000074936.9 IRAK4_MOUSE NM_029926 Q80WW1 Q8R4K2 uc007xjk.1 uc007xjk.2 uc007xjk.3 uc007xjk.4 uc007xjk.5 Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome (PubMed:16951688). Once phosphorylated, IRAK4 dissociates from the receptor complex and then associates with the TNF receptor-associated factor 6 (TRAF6), IRAK1, and PELI1; this intermediate complex is required for subsequent NF-kappa-B activation (PubMed:16951688). Direct binding of SMAD6 to PELI1 prevents complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression (By similarity). Interacts with IL1RL1 (By similarity). Interacts (when phosphorylated) with IRAK1 (By similarity). May interact (when phosphorylated) with IRAK3 (By similarity). Q8R4K2; Q8K4B2: Irak3; NbExp=7; IntAct=EBI-3842721, EBI-646179; Q8R4K2; P22366: Myd88; NbExp=8; IntAct=EBI-3842721, EBI-525108; Cytoplasm Phosphorylated. Mice are strongly altered in their responses to viral and bacterial challenges due to a severe impairment of interleukin-1 and Toll-like receptor signaling pathways. Malt1 and Irak4 double knockout suggests an additional role of Irak4 in B-cell antigen receptor (BCR) mediated signaling pathway, since the double mutant inhibits B-cell proliferation. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. nucleotide binding magnesium ion binding cytokine production immune system process neutrophil mediated immunity protein kinase activity protein serine/threonine kinase activity interleukin-1 receptor binding protein binding ATP binding extracellular space nucleus cytoplasm protein phosphorylation signal transduction JNK cascade kinase activity phosphorylation transferase activity cytokine-mediated signaling pathway intracellular signal transduction positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of smooth muscle cell proliferation neutrophil migration uc007xjk.1 uc007xjk.2 uc007xjk.3 uc007xjk.4 uc007xjk.5 
ENSMUST00000074941.8 Zfp35 ENSMUST00000074941.8 zinc finger protein 35 (from RefSeq NM_011755.2) ENSMUST00000074941.1 ENSMUST00000074941.2 ENSMUST00000074941.3 ENSMUST00000074941.4 ENSMUST00000074941.5 ENSMUST00000074941.6 ENSMUST00000074941.7 NM_011755 Q3V142 Q3V142_MOUSE Zfp35 uc008egk.1 uc008egk.2 uc008egk.3 transcription regulatory region sequence-specific DNA binding nucleic acid binding nucleus metal ion binding uc008egk.1 uc008egk.2 uc008egk.3 
ENSMUST00000074943.9 Vmn2r50 ENSMUST00000074943.9 vomeronasal 2, receptor 50 (from RefSeq NM_001105178.1) E9PW61 E9PW61_MOUSE ENSMUST00000074943.1 ENSMUST00000074943.2 ENSMUST00000074943.3 ENSMUST00000074943.4 ENSMUST00000074943.5 ENSMUST00000074943.6 ENSMUST00000074943.7 ENSMUST00000074943.8 NM_001105178 Vmn2r46 Vmn2r50 uc012eyo.1 uc012eyo.2 uc012eyo.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012eyo.1 uc012eyo.2 uc012eyo.3 
ENSMUST00000074949.4 Tmem140 ENSMUST00000074949.4 transmembrane protein 140, transcript variant 1 (from RefSeq NM_197986.3) ENSMUST00000074949.1 ENSMUST00000074949.2 ENSMUST00000074949.3 NM_197986 Q8BGY5 Q8VDY2 TM140_MOUSE uc009bhu.1 uc009bhu.2 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009bhu.1 uc009bhu.2 
ENSMUST00000074950.11 Hnrnph2 ENSMUST00000074950.11 heterogeneous nuclear ribonucleoprotein H2, transcript variant 2 (from RefSeq NM_001313716.1) ENSMUST00000074950.1 ENSMUST00000074950.10 ENSMUST00000074950.2 ENSMUST00000074950.3 ENSMUST00000074950.4 ENSMUST00000074950.5 ENSMUST00000074950.6 ENSMUST00000074950.7 ENSMUST00000074950.8 ENSMUST00000074950.9 HNRH2_MOUSE Hnrph2 NM_001313716 P70333 Q3THV9 uc009ugi.1 uc009ugi.2 uc009ugi.3 uc009ugi.4 uc009ugi.5 This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity). Component of a ribonucleoprotein complex containing mRNAs and RNA-binding proteins including DDX5, HNRNPH2 and SRSF1 as well as splicing regulator ARVCF. Interacts with TXNL4/DIM1. Nucleus, nucleoplasm nucleic acid binding RNA binding nucleus nucleoplasm cytosol biological_process postsynaptic density ribonucleoprotein complex uc009ugi.1 uc009ugi.2 uc009ugi.3 uc009ugi.4 uc009ugi.5 
ENSMUST00000074957.5 Bud13 ENSMUST00000074957.5 BUD13 homolog (from RefSeq NM_146000.2) BUD13_MOUSE ENSMUST00000074957.1 ENSMUST00000074957.2 ENSMUST00000074957.3 ENSMUST00000074957.4 NM_146000 Q8BQC0 Q8CB03 Q8R149 uc009phj.1 uc009phj.2 uc009phj.3 Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well- formed active site but still cannot catalyze the branching reaction and is composed of at least 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Component of the minor spliceosome, which splices U12-type introns (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R149-1; Sequence=Displayed; Name=2; IsoId=Q8R149-2; Sequence=VSP_025591; Belongs to the CWC26 family. mRNA splicing, via spliceosome nucleus spliceosomal complex U2-type spliceosomal complex mRNA processing RNA splicing RES complex U2-type precatalytic spliceosome uc009phj.1 uc009phj.2 uc009phj.3 
ENSMUST00000074963.9 Bbs5 ENSMUST00000074963.9 Bardet-Biedl syndrome 5, transcript variant 1 (from RefSeq NM_028284.3) A2AUC7 BBS5_MOUSE ENSMUST00000074963.1 ENSMUST00000074963.2 ENSMUST00000074963.3 ENSMUST00000074963.4 ENSMUST00000074963.5 ENSMUST00000074963.6 ENSMUST00000074963.7 ENSMUST00000074963.8 NM_028284 Q9CZQ9 uc008jyf.1 uc008jyf.2 uc008jyf.3 The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity). PPart of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Binds to phosphoinositides. Interacts with CCDC28B. Interacts with SMO; the interaction is indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO. Interacts with PKD1 (By similarity). Interacts with DLEC1 (By similarity). Cell projection, cilium membrane Cytoplasm Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Note=Localizes to basal bodies. Belongs to the BBS5 family. RNA polymerase II repressing transcription factor binding protein binding cytoplasm microtubule organizing center cytoskeleton plasma membrane cilium axoneme protein transport membrane cell projection organization phosphatidylinositol-3-phosphate binding centriolar satellite BBSome ciliary basal body cell projection intracellular transport ciliary membrane cilium assembly uc008jyf.1 uc008jyf.2 uc008jyf.3 
ENSMUST00000074969.11 Cage1 ENSMUST00000074969.11 cancer antigen 1 (from RefSeq NM_027724.2) A6X913 CAGE1_MOUSE Ctag3 ENSMUST00000074969.1 ENSMUST00000074969.10 ENSMUST00000074969.2 ENSMUST00000074969.3 ENSMUST00000074969.4 ENSMUST00000074969.5 ENSMUST00000074969.6 ENSMUST00000074969.7 ENSMUST00000074969.8 ENSMUST00000074969.9 NM_027724 Q5IR70 Q640N7 uc007qde.1 uc007qde.2 uc007qde.3 uc007qde.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5IR70-1; Sequence=Displayed; Name=2; IsoId=Q5IR70-2; Sequence=VSP_023906, VSP_023907, VSP_023908; Expressed in spermatids and spermatozoa. Localized to the acrosomal matrix and acrosomal granule. Predominantly expressed during postmeiotic stages of spermatogenesis. molecular_function cellular_component biological_process uc007qde.1 uc007qde.2 uc007qde.3 uc007qde.4 
ENSMUST00000074976.8 H2ac19 ENSMUST00000074976.8 H2A clustered histone 19 (from RefSeq NM_178212.4) ENSMUST00000074976.1 ENSMUST00000074976.2 ENSMUST00000074976.3 ENSMUST00000074976.4 ENSMUST00000074976.5 ENSMUST00000074976.6 ENSMUST00000074976.7 H2A2A_MOUSE Hist2h2aa1 Hist2h2aa2 NM_178212 P20670 Q6GSS7 Q811M3 uc008qml.1 uc008qml.2 uc008qml.3 uc008qml.4 uc008qml.5 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization nucleosome assembly protein heterodimerization activity uc008qml.1 uc008qml.2 uc008qml.3 uc008qml.4 uc008qml.5 
ENSMUST00000074986.7 Or7g21 ENSMUST00000074986.7 olfactory receptor family 7 subfamily G member 21 (from RefSeq NM_146564.2) ENSMUST00000074986.1 ENSMUST00000074986.2 ENSMUST00000074986.3 ENSMUST00000074986.4 ENSMUST00000074986.5 ENSMUST00000074986.6 NM_146564 Olfr836 Or7g21 Q8VFJ3 Q8VFJ3_MOUSE uc009ohd.1 uc009ohd.2 uc009ohd.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC106988.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ohd.1 uc009ohd.2 uc009ohd.3 
ENSMUST00000075017.5 Vpreb1a ENSMUST00000075017.5 V-set pre-B cell surrogate light chain 1A (from RefSeq NM_016982.2) ENSMUST00000075017.1 ENSMUST00000075017.2 ENSMUST00000075017.3 ENSMUST00000075017.4 NM_016982 Q545E0 Q545E0_MOUSE Vpreb1 Vpreb1a uc007yjg.1 uc007yjg.2 uc007yjg.3 uc007yjg.4 uc007yjg.1 uc007yjg.2 uc007yjg.3 uc007yjg.4 
ENSMUST00000075020.10 5430401F13Rik ENSMUST00000075020.10 5430401F13Rik (from geneSymbol) 5430401F13Rik AK017253 E9Q328 E9Q328_MOUSE ENSMUST00000075020.1 ENSMUST00000075020.2 ENSMUST00000075020.3 ENSMUST00000075020.4 ENSMUST00000075020.5 ENSMUST00000075020.6 ENSMUST00000075020.7 ENSMUST00000075020.8 ENSMUST00000075020.9 F7D4R8 uc291jnq.1 uc291jnq.2 molecular_function cellular_component biological_process uc291jnq.1 uc291jnq.2 
ENSMUST00000075025.7 Or4c99 ENSMUST00000075025.7 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt F6XP16) ENSMUST00000075025.1 ENSMUST00000075025.2 ENSMUST00000075025.3 ENSMUST00000075025.4 ENSMUST00000075025.5 ENSMUST00000075025.6 F6XP16 F6XP16_MOUSE Olfr1185 Or4c99 uc289xym.1 uc289xym.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xym.1 uc289xym.2 
ENSMUST00000075036.9 Unc13d ENSMUST00000075036.9 unc-13 homolog D (from RefSeq NM_001009573.2) A2A856 A3R4M4 A3R4M5 B2RUP2 ENSMUST00000075036.1 ENSMUST00000075036.2 ENSMUST00000075036.3 ENSMUST00000075036.4 ENSMUST00000075036.5 ENSMUST00000075036.6 ENSMUST00000075036.7 ENSMUST00000075036.8 NM_001009573 Q571J0 UN13D_MOUSE uc007mjt.1 uc007mjt.2 Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis (By similarity). Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with RAB27A and DOC2A (PubMed:18354201). Both RAB27A and DOC2A can simultaneously bind UNC13D (PubMed:18354201). Interacts with RhoG; the interaction increases RhoG affinity to the membrane lipids, targets Unc13d to membrane lipids and facilitates cytotoxic granule (CG) docking to the plasma membrane (By similarity). Cytoplasm Membrane ; Peripheral membrane protein Late endosome Recycling endosome Lysosome Note=Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B2RUP2-1; Sequence=Displayed; Name=2; IsoId=B2RUP2-2; Sequence=VSP_037950; Mast cells. The MHD1 and MHD2 domains mediate localization on recycling endosomes and lysosome. A truncating mutation is the cause of the jinxed phenotype (jinx), a chemically-induced mutation that make mice susceptible to murine cytomegalovirus (MCMV). It is a mouse model of human type 3 familial hemophagocytic lymphohistiocytosis. Affected mice produce a truncated protein that lack the second of the C2 domains and part of the second MHD domain. In jinx homozygotes, activated NK cells and cytotoxic T-lymphocytes (CTLs) fail to degranulate, although they retain the ability to produce cytokines. Mice do not spontaneously develop clinical features of hemophagocytic lymphohistiocytosis (HLH), but do so when infected with lymphocytic choriomeningitis virus (LCMV), exhibiting hyperactivation of CTLs and antigen-presenting cells, and inadequate restriction of viral proliferation. In contrast, neither Listeria monocytogenes nor MCMV induce the syndrome. Belongs to the unc-13 family. granuloma formation germinal center formation protein binding cytoplasm lysosome endosome late endosome cytosol exocytosis phagocytosis membrane Rab GTPase binding Weibel-Palade body intracellular membrane-bounded organelle regulation of mast cell degranulation natural killer cell degranulation positive regulation of exocytosis defense response to virus recycling endosome dense core granule priming exocytic vesicle positive regulation of substrate adhesion-dependent cell spreading positive regulation of regulated secretory pathway uc007mjt.1 uc007mjt.2 
ENSMUST00000075040.9 Dusp13a ENSMUST00000075040.9 dual specificity phosphatase 13a (from RefSeq NM_001007268.2) DS13A_MOUSE Dusp13 Dusp13a ENSMUST00000075040.1 ENSMUST00000075040.2 ENSMUST00000075040.3 ENSMUST00000075040.4 ENSMUST00000075040.5 ENSMUST00000075040.6 ENSMUST00000075040.7 ENSMUST00000075040.8 Mdsp NM_001007268 Q6B8I0 uc007slo.1 uc007slo.2 uc007slo.3 Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In humans, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]. Probable protein tyrosine phosphatase. Has phosphatase activity with synthetic substrates. Has a phosphatase activity- independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Monomer. Interacts with MAP3K5/ASK1; may compete with AKT1 preventing MAP3K5/ASK1 phosphorylation by AKT1. Cytoplasm Skeletal muscle-specific. Expressed at very low levels in myotubes and early postnatal muscle. Expression markedly increases at approximately the 3rd week after birth and continues to increase gradually into adulthood. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytoplasm protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc007slo.1 uc007slo.2 uc007slo.3 
ENSMUST00000075045.4 Pramel26 ENSMUST00000075045.4 PRAME like 26, transcript variant 1 (from RefSeq NM_001005371.4) A2A8N0 A2A8N0_MOUSE ENSMUST00000075045.1 ENSMUST00000075045.2 ENSMUST00000075045.3 NM_001005371 Pramel26 uc008vqn.1 uc008vqn.2 uc008vqn.3 uc008vqn.4 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vqn.1 uc008vqn.2 uc008vqn.3 uc008vqn.4 
ENSMUST00000075052.10 Kcnh7 ENSMUST00000075052.10 potassium voltage-gated channel, subfamily H (eag-related), member 7 (from RefSeq NM_133207.2) A2AUY8 ENSMUST00000075052.1 ENSMUST00000075052.2 ENSMUST00000075052.3 ENSMUST00000075052.4 ENSMUST00000075052.5 ENSMUST00000075052.6 ENSMUST00000075052.7 ENSMUST00000075052.8 ENSMUST00000075052.9 Erg3 KCNH7_MOUSE NM_133207 Q9ER47 uc008jvq.1 uc008jvq.2 uc008jvq.3 Pore-forming (alpha) subunit of voltage-gated potassium channel (By similarity). Channel properties may be modulated by cAMP and subunit assembly. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2 (By similarity). Membrane; Multi-pass membrane protein. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily. ion channel activity inward rectifier potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity integral component of plasma membrane ion transport potassium ion transport membrane integral component of membrane regulation of ion transmembrane transport regulation of membrane potential protein heterooligomerization transmembrane transport potassium ion transmembrane transport uc008jvq.1 uc008jvq.2 uc008jvq.3 
ENSMUST00000075062.5 Hcst ENSMUST00000075062.5 hematopoietic cell signal transducer (from RefSeq NM_011827.3) Dap10 ENSMUST00000075062.1 ENSMUST00000075062.2 ENSMUST00000075062.3 ENSMUST00000075062.4 HCST_MOUSE Kap10 NM_011827 Q9QUJ0 Q9R1E7 uc009geg.1 uc009geg.2 Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as a docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR- induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells. Homodimer; Disulfide-linked. Interacts with KLRK1 to form a stable complex, which results in surface expression of both proteins, whereas alone, it is minimally expressed. Interacts with PIK3R1 and GRB2. Interacts with CLEC5A (By similarity). Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP. Heterohexamer composed of four subunits of HCST/DAP10 and two subunits of KLRK1. Interacts (via transmembrane domain) with KLRK1 isoform 1 (via transmembrane domain); the interaction is required for KLRK1 cell surface expression on naive NK cells and activated CD8(+) T- cells, but is dispensable on activated TYROBP-expressing NK cells. Interacts (via transmembrane domain) with KLRK1 isoform 2 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface expression and induces NK cell-mediated cytotoxicity. Interacts with CD300H (By similarity). Q9QUJ0; Q9R007: Clec5a; NbExp=3; IntAct=EBI-15761243, EBI-15761206; Q9QUJ0; O54885: Tyrobp; NbExp=4; IntAct=EBI-15761243, EBI-15687058; Membrane ; Single- pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QUJ0-1; Sequence=Displayed; Name=2; IsoId=Q9QUJ0-2; Sequence=VSP_033023; Phosphorylated; PIK3R1 and GRB2 associate specifically with tyrosine-phosphorylated HCST. O-glycosylated. Mice exhibit low expression of KLRK1 in NK cells, but no expression in resting T-cells. KLRK1 expression is not induced upon T-cell activation, while it is up-regulated in activated NK cells; NK cells promote KLRK1-mediated tumor rejection due to substitution of HCST by DAP12/TYROBP. Mice lacking HCST exhibit antitumor phenotype; they show enhanced immunity against melanoma malignancies due to hyperactive functioning of a group of T-cells that share properties of both T-cells and NK cells (NKT cells). NKT cells exhibit increased cytokine production and cytotoxicity, leading to efficient killing of melanoma tumors. Upon activation, T regulatory cells (Tregs) maintain higher levels of IL2 and produced significantly lower amounts of IL10 and IFN-gamma cytokines. NKT cells activated by IL2 efficiently lyse B16-melanoma tumors in vitro in an KLRK1-independent way; The hyperactivity of NKT cells in these mice is not related to signaling of KLRK1. Immune reactivity to healthy cells that express KLRK1 ligands can happen under physiological conditions; NK cells are able to reject syngeneic bone marrow grafts when the bone marrow cells expressed sufficient KLRK1 ligand. Belongs to the DAP10 family. receptor binding protein binding protein phosphorylation cell surface positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane phosphatidylinositol 3-kinase binding regulation of immune response uc009geg.1 uc009geg.2 
ENSMUST00000075068.14 Pepd ENSMUST00000075068.14 peptidase D, transcript variant 1 (from RefSeq NM_008820.3) ENSMUST00000075068.1 ENSMUST00000075068.10 ENSMUST00000075068.11 ENSMUST00000075068.12 ENSMUST00000075068.13 ENSMUST00000075068.2 ENSMUST00000075068.3 ENSMUST00000075068.4 ENSMUST00000075068.5 ENSMUST00000075068.6 ENSMUST00000075068.7 ENSMUST00000075068.8 ENSMUST00000075068.9 NM_008820 P97735 PEPD_MOUSE Pep4 Q11136 Q3TH86 Q9CWK4 uc009gjj.1 uc009gjj.2 uc009gjj.3 uc009gjj.4 Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position. The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved. Plays an important role in collagen metabolism because the high level of iminoacids in collagen. Reaction=H2O + Xaa-L-Pro dipeptide = an L-alpha-amino acid + L-proline; Xref=Rhea:RHEA:76407, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869, ChEBI:CHEBI:60039, ChEBI:CHEBI:195196; EC=3.4.13.9; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; Homodimer. Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily. aminopeptidase activity nucleus nucleoplasm proteolysis peptidase activity metallopeptidase activity hydrolase activity dipeptidase activity manganese ion binding collagen catabolic process metal ion binding proline dipeptidase activity uc009gjj.1 uc009gjj.2 uc009gjj.3 uc009gjj.4 
ENSMUST00000075072.6 Gpr65 ENSMUST00000075072.6 G-protein coupled receptor 65 (from RefSeq NM_008152.3) A0A0R4J0Y2 A0A0R4J0Y2_MOUSE ENSMUST00000075072.1 ENSMUST00000075072.2 ENSMUST00000075072.3 ENSMUST00000075072.4 ENSMUST00000075072.5 Gpr65 NM_008152 uc007olg.1 uc007olg.2 uc007olg.3 uc007olg.4 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway response to acidic pH membrane integral component of membrane actin cytoskeleton reorganization positive regulation of stress fiber assembly activation of GTPase activity uc007olg.1 uc007olg.2 uc007olg.3 uc007olg.4 
ENSMUST00000075081.9 1500035N22Rik ENSMUST00000075081.9 RIKEN cDNA 1500035N22 gene (from RefSeq NR_166410.1) ENSMUST00000075081.1 ENSMUST00000075081.2 ENSMUST00000075081.3 ENSMUST00000075081.4 ENSMUST00000075081.5 ENSMUST00000075081.6 ENSMUST00000075081.7 ENSMUST00000075081.8 NR_166410 uc008wsp.1 uc008wsp.2 uc008wsp.3 uc008wsp.4 uc008wsp.5 uc008wsp.1 uc008wsp.2 uc008wsp.3 uc008wsp.4 uc008wsp.5 
ENSMUST00000075084.5 Trim58 ENSMUST00000075084.5 tripartite motif-containing 58 (from RefSeq NM_001039047.2) ENSMUST00000075084.1 ENSMUST00000075084.2 ENSMUST00000075084.3 ENSMUST00000075084.4 Gm16 NM_001039047 Q5NCC9 TRI58_MOUSE uc007jby.1 uc007jby.2 E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Expressed in erythroblasts. The RING finger is required for ubiquitin ligase activity. Belongs to the TRIM/RBCC family. protein polyubiquitination cellular_component ubiquitin-dependent protein catabolic process zinc ion binding protein ubiquitination transferase activity dynein heavy chain binding dynein intermediate chain binding metal ion binding protein autoubiquitination ubiquitin protein ligase activity regulation of nuclear migration along microtubule uc007jby.1 uc007jby.2 
ENSMUST00000075085.7 Vmn1r63 ENSMUST00000075085.7 vomeronasal 1 receptor 63 (from RefSeq NM_030742.1) E9PV27 ENSMUST00000075085.1 ENSMUST00000075085.2 ENSMUST00000075085.3 ENSMUST00000075085.4 ENSMUST00000075085.5 ENSMUST00000075085.6 NM_030742 Q0VDQ1 Q9EPT1 Q9EPT1_MOUSE V1rd1 Vmn1r63 uc009fak.1 uc009fak.2 uc009fak.3 uc009fak.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009fak.1 uc009fak.2 uc009fak.3 uc009fak.4 
ENSMUST00000075095.7 Vmn2r24 ENSMUST00000075095.7 vomeronasal 2, receptor 24 (from RefSeq NM_001104639.1) D3YUI0 D3YUI0_MOUSE ENSMUST00000075095.1 ENSMUST00000075095.2 ENSMUST00000075095.3 ENSMUST00000075095.4 ENSMUST00000075095.5 ENSMUST00000075095.6 NM_001104639 Vmn2r24 uc009vdz.1 uc009vdz.2 uc009vdz.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vdz.1 uc009vdz.2 uc009vdz.3 
ENSMUST00000075108.9 Vmn2r31 ENSMUST00000075108.9 vomeronasal 2, receptor 31 (from RefSeq NM_001385037.1) ENSMUST00000075108.1 ENSMUST00000075108.2 ENSMUST00000075108.3 ENSMUST00000075108.4 ENSMUST00000075108.5 ENSMUST00000075108.6 ENSMUST00000075108.7 ENSMUST00000075108.8 L7N1Z4 L7N1Z4_MOUSE NM_001385037 Vmn2r31 uc012exs.1 uc012exs.2 uc012exs.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012exs.1 uc012exs.2 uc012exs.3 
ENSMUST00000075141.7 Trim17 ENSMUST00000075141.7 tripartite motif-containing 17 (from RefSeq NM_031172.3) A2AB82 ENSMUST00000075141.1 ENSMUST00000075141.2 ENSMUST00000075141.3 ENSMUST00000075141.4 ENSMUST00000075141.5 ENSMUST00000075141.6 NM_031172 Q7TPM3 Q99PP8 TRI17_MOUSE uc007jcv.1 uc007jcv.2 uc007jcv.3 E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation (PubMed:20559321, PubMed:22976837, PubMed:25215946). Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation. Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy- inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (By similarity). Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death (PubMed:22976837). In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities (PubMed:25215946). Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (PubMed:30485814). Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti- apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts (via coiled coil) with TRIM44 (via coiled coil). Interacts with TRIM28; this interaction prevents TRIM28 activity on BCL2A1 (By similarity). Interacts with TRIM41; this interaction prevents TRIM41 activity on ZSCAN2 (By similarity). Interacts with BECN1 (By similarity). Interacts with NFATC3 and NFATC4; these interactions prevent NFATC3 and NFATC4 nuclear localization (PubMed:25215946). Cytoplasm Lysosome Almost exclusively in the testis. By NFATC3 and JUN cooperation during neuronal apoptosis. Auto-ubiquitinated. Belongs to the TRIM/RBCC family. ubiquitin-protein transferase activity cellular_component autophagy zinc ion binding protein ubiquitination transferase activity protein binding, bridging regulation of protein localization metal ion binding protein autoubiquitination uc007jcv.1 uc007jcv.2 uc007jcv.3 
ENSMUST00000075161.12 Actg2 ENSMUST00000075161.12 actin, gamma 2, smooth muscle, enteric (from RefSeq NM_009610.2) Actg2 ENSMUST00000075161.1 ENSMUST00000075161.10 ENSMUST00000075161.11 ENSMUST00000075161.2 ENSMUST00000075161.3 ENSMUST00000075161.4 ENSMUST00000075161.5 ENSMUST00000075161.6 ENSMUST00000075161.7 ENSMUST00000075161.8 ENSMUST00000075161.9 NM_009610 Q3UJ36 Q3UJ36_MOUSE uc012eoa.1 uc012eoa.2 uc012eoa.3 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Cytoplasm, cytoskeleton Belongs to the actin family. nucleotide binding ATP binding cytoplasm cytoskeleton positive regulation of gene expression lamellipodium filopodium myosin filament cell body mesenchyme migration uc012eoa.1 uc012eoa.2 uc012eoa.3 
ENSMUST00000075162.5 Klk1 ENSMUST00000075162.5 kallikrein 1, transcript variant 1 (from RefSeq NM_010639.8) ENSMUST00000075162.1 ENSMUST00000075162.2 ENSMUST00000075162.3 ENSMUST00000075162.4 KLK1_MOUSE Klk-6 Klk6 NM_010639 P15947 Q61855 uc009goo.1 uc009goo.2 uc009goo.3 uc009goo.4 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein are unable to generate significant levels of kinins in most tissues, develop cardiovascular abnormalities and exhibit hypercalciuria of renal origin. This gene is located in a cluster of several related kallikrein genes on chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, Feb 2016]. Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Reaction=Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl- bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|- Xaa.; EC=3.4.21.35; Belongs to the peptidase S1 family. Kallikrein subfamily. regulation of systemic arterial blood pressure endopeptidase activity serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides secretory granule zymogen activation macromolecular complex uc009goo.1 uc009goo.2 uc009goo.3 uc009goo.4 
ENSMUST00000075164.11 Kif21b ENSMUST00000075164.11 kinesin family member 21B, transcript variant 1 (from RefSeq NM_001039472.2) ENSMUST00000075164.1 ENSMUST00000075164.10 ENSMUST00000075164.2 ENSMUST00000075164.3 ENSMUST00000075164.4 ENSMUST00000075164.5 ENSMUST00000075164.6 ENSMUST00000075164.7 ENSMUST00000075164.8 ENSMUST00000075164.9 F8VQE2 F8VQE2_MOUSE Kif21b NM_001039472 uc007cul.1 uc007cul.2 uc007cul.3 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding motor activity microtubule motor activity ATP binding microtubule-based movement microtubule binding uc007cul.1 uc007cul.2 uc007cul.3 
ENSMUST00000075172.12 Tspan32 ENSMUST00000075172.12 tetraspanin 32, transcript variant 2 (from RefSeq NM_020286.3) ENSMUST00000075172.1 ENSMUST00000075172.10 ENSMUST00000075172.11 ENSMUST00000075172.2 ENSMUST00000075172.3 ENSMUST00000075172.4 ENSMUST00000075172.5 ENSMUST00000075172.6 ENSMUST00000075172.7 ENSMUST00000075172.8 ENSMUST00000075172.9 NM_020286 Q3U3L6 Q3U3L6_MOUSE Tspan32 uc009kon.1 uc009kon.2 uc009kon.3 uc009kon.4 uc009kon.5 membrane integral component of membrane uc009kon.1 uc009kon.2 uc009kon.3 uc009kon.4 uc009kon.5 
ENSMUST00000075175.12 Rex1bd ENSMUST00000075175.12 required for excision 1-B domain containing, transcript variant 1 (from RefSeq NM_025577.3) ENSMUST00000075175.1 ENSMUST00000075175.10 ENSMUST00000075175.11 ENSMUST00000075175.2 ENSMUST00000075175.3 ENSMUST00000075175.4 ENSMUST00000075175.5 ENSMUST00000075175.6 ENSMUST00000075175.7 ENSMUST00000075175.8 ENSMUST00000075175.9 NM_025577 Q3TUY7 Q9CRH2 Q9CYZ6 REX1B_MOUSE Rex1bd uc009mal.1 uc009mal.2 uc009mal.3 Sequence=BAB27079.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc009mal.1 uc009mal.2 uc009mal.3 
ENSMUST00000075181.11 Plekha1 ENSMUST00000075181.11 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1, transcript variant 7 (from RefSeq NM_001382376.1) ENSMUST00000075181.1 ENSMUST00000075181.10 ENSMUST00000075181.2 ENSMUST00000075181.3 ENSMUST00000075181.4 ENSMUST00000075181.5 ENSMUST00000075181.6 ENSMUST00000075181.7 ENSMUST00000075181.8 ENSMUST00000075181.9 NM_001382376 PKHA1_MOUSE Q8BK96 Q8BUL6 Q8BXU1 Q8VE13 Tapp1 uc009kar.1 uc009kar.2 uc009kar.3 Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). Interacts with MPDZ and PTPN13. Cytoplasm Cell membrane ; Peripheral membrane protein Nucleus Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BUL6-1; Sequence=Displayed; Name=2; IsoId=Q8BUL6-2; Sequence=VSP_009764, VSP_009767; Binds to membranes enriched in PtdIns3,4P2 via the C-terminal PH domain. luteinization nucleus nucleoplasm cytoplasm cytosol plasma membrane spermatogenesis androgen metabolic process estrogen metabolic process lipid binding female gonad development post-embryonic development phosphatidylinositol 3-kinase signaling membrane PDZ domain binding ruffle organization ruffle membrane Leydig cell differentiation multicellular organism growth phosphatidylinositol-3,4-bisphosphate binding establishment of protein localization platelet-derived growth factor receptor signaling pathway skeletal system morphogenesis B cell receptor signaling pathway negative regulation of protein kinase B signaling palate development face morphogenesis cellular response to hydrogen peroxide uc009kar.1 uc009kar.2 uc009kar.3 
ENSMUST00000075190.5 Cdh11 ENSMUST00000075190.5 cadherin 11, transcript variant 1 (from RefSeq NM_009866.6) CAD11_MOUSE Cad-11 ENSMUST00000075190.1 ENSMUST00000075190.2 ENSMUST00000075190.3 ENSMUST00000075190.4 NM_009866 P55288 uc009mzu.1 uc009mzu.2 uc009mzu.3 uc009mzu.4 This gene encodes a type II classical cadherin and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is an integral membrane protein that mediates calcium-dependent cell-cell adhesion, specifically in the context of bone development. Homozygous knockout mice for this gene exhibit impaired synovium development and reduced bone density. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK049652.1, X77557.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly. Involved in the regulation of cell migration. Interacts with PCDH8. Cell membrane; Single-pass type I membrane protein. Selectively expressed in osteoblastic cell lines, precursor cell lines of osteoblasts, and primary osteoblastic cells from calvaria, as well as in lung, testis, and brain tissues at low levels. In the testis, expression is highest in fetal gonad and decreases 8-fold in newborn. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. cell morphogenesis calcium ion binding cytoplasm plasma membrane cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cytoskeletal protein binding cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex corticospinal tract morphogenesis adherens junction organization protein homodimerization activity cell-cell adhesion mediated by cadherin synapse cadherin binding metal ion binding modulation of synaptic transmission cell-cell adhesion glutamatergic synapse uc009mzu.1 uc009mzu.2 uc009mzu.3 uc009mzu.4 
ENSMUST00000075192.13 Nfe2 ENSMUST00000075192.13 nuclear factor, erythroid derived 2, transcript variant 2 (from RefSeq NM_008685.4) A0A0R4J0Y5 A0A0R4J0Y5_MOUSE ENSMUST00000075192.1 ENSMUST00000075192.10 ENSMUST00000075192.11 ENSMUST00000075192.12 ENSMUST00000075192.2 ENSMUST00000075192.3 ENSMUST00000075192.4 ENSMUST00000075192.5 ENSMUST00000075192.6 ENSMUST00000075192.7 ENSMUST00000075192.8 ENSMUST00000075192.9 NM_008685 Nfe2 uc007xxu.1 uc007xxu.2 uc007xxu.3 Belongs to the bZIP family. CNC subfamily. core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein-DNA complex protein N-terminus binding WW domain binding uc007xxu.1 uc007xxu.2 uc007xxu.3 
ENSMUST00000075206.12 Mup14 ENSMUST00000075206.12 major urinary protein 14 (from RefSeq NM_001199999.1) A2CEK7 A2CEK7_MOUSE ENSMUST00000075206.1 ENSMUST00000075206.10 ENSMUST00000075206.11 ENSMUST00000075206.2 ENSMUST00000075206.3 ENSMUST00000075206.4 ENSMUST00000075206.5 ENSMUST00000075206.6 ENSMUST00000075206.7 ENSMUST00000075206.8 ENSMUST00000075206.9 Mup12 Mup14 NM_001199999 OTTMUSG00000012493 uc012dfi.1 uc012dfi.2 uc012dfi.3 uc012dfi.4 uc012dfi.5 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc012dfi.1 uc012dfi.2 uc012dfi.3 uc012dfi.4 uc012dfi.5 
ENSMUST00000075214.9 Dsc2 ENSMUST00000075214.9 desmocollin 2, transcript variant Dsc2a (from RefSeq NM_001317365.1) DSC2_MOUSE Dsc3 ENSMUST00000075214.1 ENSMUST00000075214.2 ENSMUST00000075214.3 ENSMUST00000075214.4 ENSMUST00000075214.5 ENSMUST00000075214.6 ENSMUST00000075214.7 ENSMUST00000075214.8 NM_001317365 P55292 Q64734 uc008eec.1 uc008eec.2 uc008eec.3 uc008eec.4 This gene encodes a member of the desmocollin protein subfamily. Desmocollins are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. Event=Alternative splicing; Named isoforms=2; Name=2A; IsoId=P55292-1; Sequence=Displayed; Name=2B; IsoId=P55292-2; Sequence=VSP_000659, VSP_000660; In all epithelia tested and heart. Calcium may be bound by the cadherin-like repeats. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. calcium ion binding plasma membrane cell-cell junction cell-cell adherens junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cellular response to starvation intercalated disc membrane integral component of membrane cell junction desmosome cytoplasmic vesicle metal ion binding cardiac muscle cell-cardiac muscle cell adhesion bundle of His cell-Purkinje myocyte adhesion involved in cell communication regulation of heart rate by cardiac conduction cell-cell adhesion regulation of ventricular cardiac muscle cell action potential uc008eec.1 uc008eec.2 uc008eec.3 uc008eec.4 
ENSMUST00000075221.3 Osm ENSMUST00000075221.3 oncostatin M (from RefSeq NM_001013365.3) ENSMUST00000075221.1 ENSMUST00000075221.2 NM_001013365 ONCM_MOUSE P53347 Q3U1Y5 Q5SPX6 uc007hus.1 uc007hus.2 uc007hus.3 uc007hus.4 Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G- CSF and GM-CSF from endothelial cells (By similarity). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). Secreted. Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity. Belongs to the LIF/OSM family. cytokine activity oncostatin-M receptor binding extracellular region extracellular space immune response tyrosine phosphorylation of STAT protein peripheral nervous system development growth factor activity positive regulation of cell proliferation response to heat positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of peptidyl-serine phosphorylation oncostatin-M-mediated signaling pathway regulation of growth positive regulation of tyrosine phosphorylation of STAT protein positive regulation of MAPK cascade negative regulation of meiotic nuclear division positive regulation of transcription from RNA polymerase II promoter negative regulation of hormone secretion behavioral response to pain positive regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein kinase B signaling positive regulation of interleukin-17 secretion positive regulation of apoptotic signaling pathway uc007hus.1 uc007hus.2 uc007hus.3 uc007hus.4 
ENSMUST00000075242.7 Hspe1 ENSMUST00000075242.7 heat shock protein 1 (chaperonin 10) (from RefSeq NM_008303.4) CH10_MOUSE ENSMUST00000075242.1 ENSMUST00000075242.2 ENSMUST00000075242.3 ENSMUST00000075242.4 ENSMUST00000075242.5 ENSMUST00000075242.6 NM_008303 Q64433 uc007bac.1 uc007bac.2 uc007bac.3 uc007bac.4 Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. Homoheptamer arranged in a ring structure. 2 heptameric Hsp10 rings interact with a Hsp60 tetradecamer in the structure of a back-to- back double heptameric ring to form the symmetrical football complex. Mitochondrion matrix By stress. Belongs to the GroES chaperonin family. ATP binding mitochondrion mitochondrial matrix protein folding metal ion binding unfolded protein binding chaperone mediated protein folding requiring cofactor chaperone binding uc007bac.1 uc007bac.2 uc007bac.3 uc007bac.4 
ENSMUST00000075249.6 Plekhg3 ENSMUST00000075249.6 pleckstrin homology domain containing, family G (with RhoGef domain) member 3, transcript variant 2 (from RefSeq NM_153804.5) E9QL46 ENSMUST00000075249.1 ENSMUST00000075249.2 ENSMUST00000075249.3 ENSMUST00000075249.4 ENSMUST00000075249.5 Kiaa0599 NM_153804 PKHG3_MOUSE Plekhg3 Q3TSI8 Q4VAC9 Q6A041 Q8BJP5 Q8K0L5 Q8K0T6 uc007nyk.1 uc007nyk.2 uc007nyk.3 uc007nyk.4 Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. Cytoplasm, cytoskeleton Note=Colocalizes with actin at the leading edge of polarized cells. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q4VAC9-1; Sequence=Displayed; Name=2; IsoId=Q4VAC9-2; Sequence=VSP_028540, VSP_028541; Name=3; IsoId=Q4VAC9-3; Sequence=VSP_028539, VSP_028542; Name=4; IsoId=Q4VAC9-4; Sequence=VSP_028536, VSP_028537, VSP_028538; Name=5; IsoId=Q4VAC9-5; Sequence=VSP_028535; Sequence=BAE36687.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function Rho guanyl-nucleotide exchange factor activity cellular_component biological_process regulation of Rho protein signal transduction uc007nyk.1 uc007nyk.2 uc007nyk.3 uc007nyk.4 
ENSMUST00000075253.13 Cyp4f13 ENSMUST00000075253.13 cytochrome P450, family 4, subfamily f, polypeptide 13, transcript variant 1 (from RefSeq NM_130882.2) Cyp4f13 ENSMUST00000075253.1 ENSMUST00000075253.10 ENSMUST00000075253.11 ENSMUST00000075253.12 ENSMUST00000075253.2 ENSMUST00000075253.3 ENSMUST00000075253.4 ENSMUST00000075253.5 ENSMUST00000075253.6 ENSMUST00000075253.7 ENSMUST00000075253.8 ENSMUST00000075253.9 NM_130882 Q99N19 Q99N19_MOUSE uc008bxt.1 uc008bxt.2 uc008bxt.3 Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cellular_component leukotriene metabolic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc008bxt.1 uc008bxt.2 uc008bxt.3 
ENSMUST00000075255.6 Zfp874a ENSMUST00000075255.6 zinc finger protein 874a (from RefSeq NM_177712.4) ENSMUST00000075255.1 ENSMUST00000075255.2 ENSMUST00000075255.3 ENSMUST00000075255.4 ENSMUST00000075255.5 NM_177712 Q8BX23 Q8BX23_MOUSE Rslcan15 Zfp874 Zfp874a uc007rav.1 uc007rav.2 uc007rav.3 uc007rav.4 Nucleus nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007rav.1 uc007rav.2 uc007rav.3 uc007rav.4 
ENSMUST00000075258.13 Pitpnm3 ENSMUST00000075258.13 PITPNM family member 3, transcript variant 1 (from RefSeq NM_001024927.2) A6QRE8 ENSMUST00000075258.1 ENSMUST00000075258.10 ENSMUST00000075258.11 ENSMUST00000075258.12 ENSMUST00000075258.2 ENSMUST00000075258.3 ENSMUST00000075258.4 ENSMUST00000075258.5 ENSMUST00000075258.6 ENSMUST00000075258.7 ENSMUST00000075258.8 ENSMUST00000075258.9 NM_001024927 Nir1 PITM3_MOUSE Q3UH22 Q3UHE1 Q5RIT9 uc007jya.1 uc007jya.2 uc007jya.3 Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions (By similarity). Interacts with PTK2B via its C-terminus. Endomembrane system ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UHE1-1; Sequence=Displayed; Name=2; IsoId=Q3UHE1-2; Sequence=VSP_017966; Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. phospholipase activity calcium ion binding lipid binding endomembrane system membrane receptor tyrosine kinase binding cell projection cell body metal ion binding uc007jya.1 uc007jya.2 uc007jya.3 
ENSMUST00000075268.5 Defa34 ENSMUST00000075268.5 defensin, alpha, 34 (from RefSeq NM_001177528.1) D3Z0J0 D3Z0J0_MOUSE Defa34 ENSMUST00000075268.1 ENSMUST00000075268.2 ENSMUST00000075268.3 ENSMUST00000075268.4 NM_001177528 uc009lbu.1 uc009lbu.2 uc009lbu.3 uc009lbu.4 Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc009lbu.1 uc009lbu.2 uc009lbu.3 uc009lbu.4 
ENSMUST00000075280.12 Exosc1 ENSMUST00000075280.12 exosome component 1, transcript variant 1 (from RefSeq NM_025644.4) Csl4 ENSMUST00000075280.1 ENSMUST00000075280.10 ENSMUST00000075280.11 ENSMUST00000075280.2 ENSMUST00000075280.3 ENSMUST00000075280.4 ENSMUST00000075280.5 ENSMUST00000075280.6 ENSMUST00000075280.7 ENSMUST00000075280.8 ENSMUST00000075280.9 EXOS1_MOUSE NM_025644 Q9DAA6 Q9DCB9 uc008hmm.1 uc008hmm.2 uc008hmm.3 uc008hmm.4 Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8 (By similarity). Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with EXOSC5, EXOSC7 and EXOSC10 (By similarity). Interacts with DDX60 (By similarity). Nucleus, nucleolus. Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DAA6-1; Sequence=Displayed; Name=2; IsoId=Q9DAA6-2; Sequence=VSP_004176; Belongs to the CSL4 family. nuclear exosome (RNase complex) exosome (RNase complex) RNA binding protein binding nucleus nucleolus cytoplasm rRNA processing RNA processing uc008hmm.1 uc008hmm.2 uc008hmm.3 uc008hmm.4 
ENSMUST00000075282.10 Unc5c ENSMUST00000075282.10 unc-5 netrin receptor C, transcript variant 1 (from RefSeq NM_001293561.2) ENSMUST00000075282.1 ENSMUST00000075282.2 ENSMUST00000075282.3 ENSMUST00000075282.4 ENSMUST00000075282.5 ENSMUST00000075282.6 ENSMUST00000075282.7 ENSMUST00000075282.8 ENSMUST00000075282.9 NM_001293561 Q3UQ08 Q3UQ08_MOUSE Unc5c uc008rof.1 uc008rof.2 uc008rof.3 uc008rof.4 Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Cell membrane ingle-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the unc-5 family. netrin receptor activity plasma membrane signal transduction tubulin binding membrane integral component of membrane protein kinase binding netrin-activated signaling pathway dorsal root ganglion development uc008rof.1 uc008rof.2 uc008rof.3 uc008rof.4 
ENSMUST00000075284.4 Krtap19-3 ENSMUST00000075284.4 keratin associated protein 19-3 (from RefSeq NM_130857.2) ENSMUST00000075284.1 ENSMUST00000075284.2 ENSMUST00000075284.3 KR193_MOUSE Krtap16-5 Krtap16.5 NM_130857 Q925H6 uc007zvj.1 uc007zvj.2 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Strong expression in narrowly defined pattern restricted to the lower and middle cortical regions of the hair shaft in both developing and cycling hair. During hair follicle regression (catagen), expression levels decrease until expression is no longer detectable in follicles at resting stage (telogen). Expression in skin and hair follicle is regulated by HOXC13 and by GATA3. Belongs to the KRTAP type 19 family. molecular_function cellular_component intermediate filament biological_process uc007zvj.1 uc007zvj.2 
ENSMUST00000075296.4 Mrgprh ENSMUST00000075296.4 MAS-related GPR, member H (from RefSeq NM_030726.1) ENSMUST00000075296.1 ENSMUST00000075296.2 ENSMUST00000075296.3 Mgrb Mrgprh NM_030726 W8W3M0 W8W3M0_MOUSE uc008alg.1 uc008alg.2 uc008alg.3 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc008alg.1 uc008alg.2 uc008alg.3 
ENSMUST00000075303.7 Hdhd5 ENSMUST00000075303.7 haloacid dehalogenase like hydrolase domain containing 5 (from RefSeq NM_144815.2) Cecr5 ENSMUST00000075303.1 ENSMUST00000075303.2 ENSMUST00000075303.3 ENSMUST00000075303.4 ENSMUST00000075303.5 ENSMUST00000075303.6 HDHD5_MOUSE Hdhd5 NM_144815 Q91WM2 uc009dnl.1 uc009dnl.2 uc009dnl.3 Belongs to the HAD-like hydrolase superfamily. molecular_function mitochondrion glycerophospholipid biosynthetic process uc009dnl.1 uc009dnl.2 uc009dnl.3 
ENSMUST00000075304.14 Stx3 ENSMUST00000075304.14 syntaxin 3, transcript variant F (from RefSeq NR_153433.1) ENSMUST00000075304.1 ENSMUST00000075304.10 ENSMUST00000075304.11 ENSMUST00000075304.12 ENSMUST00000075304.13 ENSMUST00000075304.2 ENSMUST00000075304.3 ENSMUST00000075304.4 ENSMUST00000075304.5 ENSMUST00000075304.6 ENSMUST00000075304.7 ENSMUST00000075304.8 ENSMUST00000075304.9 NR_153433 Q3TBP0 Q64704 Q8R1B7 STX3_MOUSE Stx3a uc008gsy.1 uc008gsy.2 uc008gsy.3 Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles (By similarity). Essential for survival of retinal photoreceetors (PubMed:33974130). Interacts with REEP6 (PubMed:28369466). Isoform 3B interacts with PRPH2 in rod and cone photoreceptors (PubMed:26406599). Isoform 3B interacts with ROM1 (PubMed:26406599). Isoform 3B interacts with SNAP25 (PubMed:26406599). Isoform 3B interacts with VAMP2 (PubMed:26406599). Membrane ; Single-pass type IV membrane protein Note=Localized to the inner and outer plexiform layers, the cell body and the inner segments of photoreceptors. [Isoform 3B]: Photoreceptor inner segment Cell projection, cilium, photoreceptor outer segment Note=Colocalizes with SNAP25 and ROM1 in the inner segment and outer nuclear layer of the retina (at protein level) (PubMed:26406599). Partially colocalizes with PRPH2 in the inner segment of the retina (at protein level) (PubMed:26406599). Event=Alternative splicing; Named isoforms=4; Name=3A ; IsoId=Q64704-1; Sequence=Displayed; Name=3B ; IsoId=Q64704-2; Sequence=VSP_006346; Name=3C ; IsoId=Q64704-3; Sequence=VSP_006341, VSP_006346; Name=3D ; IsoId=Q64704-4; Sequence=VSP_006342, VSP_006344; Expressed in the retina (at protein level). Knockout animals show progressive photoreceptor degeneration. At 5 weeks of age, an approximately 60% decrease in thickness of the outer nuclear layer (ONL) and in the number of ONL neuronal somata is observed, indicating that a large number of photoreceptors have died. In some of the remaining rods, rhodopsin is appropriately localized to the outer segments, but a marked amount of rhodopsin mislocalized to the outer plexiform layer. At 8 and 12 weeks of age, increasing cell loss and further ectopic expression of rhodopsin are observed. Cone photoreceptor loss and ectopic expression of opsin in cones is also observed. Quantification of the progressive degenerative phenotype reveals a rapid loss in the number of neuronal somata in the ONL, indicative of photoreceptor death, whereas the number of cells in the inner nuclear layer, including horizontal, bipolar, and amacrine cells, is no different from that of controls. Belongs to the syntaxin family. SNARE binding SNAP receptor activity protein binding plasma membrane cell-cell junction neurotransmitter transport intracellular protein transport exocytosis vesicle fusion synaptic vesicle positive regulation of cell proliferation endomembrane system membrane integral component of membrane synaptic vesicle docking vesicle-mediated transport apical plasma membrane lamellipodium secretory granule dendrite growth cone neuron projection development SNARE complex synaptic vesicle fusion to presynaptic active zone membrane melanosome specific granule azurophil granule zymogen granule membrane presynaptic membrane neuron projection positive regulation of cell adhesion vesicle docking presynaptic active zone membrane arachidonic acid binding positive regulation of chemotaxis long-term synaptic potentiation membrane fusion ribbon synapse postsynapse exocytic insertion of neurotransmitter receptor to postsynaptic membrane glutamatergic synapse vesicle-mediated transport in synapse positive regulation of protein localization to plasma membrane photoreceptor cell terminal bouton positive regulation of protein localization to cell surface uc008gsy.1 uc008gsy.2 uc008gsy.3 
ENSMUST00000075312.5 Ttr ENSMUST00000075312.5 transthyretin (from RefSeq NM_013697.5) ENSMUST00000075312.1 ENSMUST00000075312.2 ENSMUST00000075312.3 ENSMUST00000075312.4 NM_013697 Q5M9K1 Q5M9K1_MOUSE Ttr uc008eet.1 uc008eet.2 uc008eet.3 uc008eet.4 This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease. [provided by RefSeq, Mar 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK014454.1, D89076.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4. Secreted Belongs to the transthyretin family. extracellular region extracellular space macromolecular complex hormone binding retinol metabolic process identical protein binding protein heterodimerization activity thyroid hormone binding thyroid hormone transport uc008eet.1 uc008eet.2 uc008eet.3 uc008eet.4 
ENSMUST00000075316.10 Gria2 ENSMUST00000075316.10 glutamate receptor, ionotropic, AMPA2 (alpha 2), transcript variant 8 (from RefSeq NR_152149.1) ENSMUST00000075316.1 ENSMUST00000075316.2 ENSMUST00000075316.3 ENSMUST00000075316.4 ENSMUST00000075316.5 ENSMUST00000075316.6 ENSMUST00000075316.7 ENSMUST00000075316.8 ENSMUST00000075316.9 G5E8H1 G5E8H1_MOUSE Gria2 NR_152149 uc008poa.1 uc008poa.2 uc008poa.3 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660825.118687.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## undergoes RNA editing :: PMID: 1717158, 12045112 ##RefSeq-Attributes-END## Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Postsynaptic density membrane ; Multi-pass membrane protein Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily. ionotropic glutamate receptor activity ion channel activity plasma membrane ion transport ligand-gated ion channel activity membrane integral component of membrane cell junction ion transmembrane transport ionotropic glutamate receptor signaling pathway signaling receptor activity synapse postsynaptic membrane uc008poa.1 uc008poa.2 uc008poa.3 
ENSMUST00000075317.12 Pdzd2 ENSMUST00000075317.12 PDZ domain containing 2 (from RefSeq NM_001081064.2) E9Q1M1 E9Q1M1_MOUSE ENSMUST00000075317.1 ENSMUST00000075317.10 ENSMUST00000075317.11 ENSMUST00000075317.2 ENSMUST00000075317.3 ENSMUST00000075317.4 ENSMUST00000075317.5 ENSMUST00000075317.6 ENSMUST00000075317.7 ENSMUST00000075317.8 ENSMUST00000075317.9 NM_001081064 Pdzd2 uc007vhq.1 uc007vhq.2 uc007vhq.3 extracellular region nucleus cytoplasm endoplasmic reticulum cell-cell junction postsynaptic density neuron projection apical part of cell uc007vhq.1 uc007vhq.2 uc007vhq.3 
ENSMUST00000075329.3 Or10x4 ENSMUST00000075329.3 olfactory receptor family 10 subfamily X member 4 (from RefSeq NM_146714.2) E9Q1L6 E9Q1L6_MOUSE ENSMUST00000075329.1 ENSMUST00000075329.2 NM_146714 Olfr248 Or10x4 uc007dta.1 uc007dta.2 uc007dta.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript is intronless :: BC131960.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007dta.1 uc007dta.2 uc007dta.3 
ENSMUST00000075340.12 Ctnna2 ENSMUST00000075340.12 catenin alpha 2, transcript variant 1 (from RefSeq NM_145732.2) CTNA2_MOUSE Catna2 ENSMUST00000075340.1 ENSMUST00000075340.10 ENSMUST00000075340.11 ENSMUST00000075340.2 ENSMUST00000075340.3 ENSMUST00000075340.4 ENSMUST00000075340.5 ENSMUST00000075340.6 ENSMUST00000075340.7 ENSMUST00000075340.8 ENSMUST00000075340.9 NM_145732 Q3TY37 Q61300 Q61301 Q6AXD1 uc291fxr.1 uc291fxr.2 May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (PubMed:12123610, PubMed:15034585). Required for proper regulation of cortical neuronal migration and neurite growth. It acts as a negative regulator of Arp2/3 complex activity and Arp2/3- mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability (By similarity). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (PubMed:12089526). Interacts with CDH1 and CDH2 (By similarity). Interacts with ZNF639; recruits CTNNA2 to the nucleus (By similarity). Interacts with F-actin (By similarity). Q61301; Q61301: Ctnna2; NbExp=2; IntAct=EBI-774089, EBI-774089; Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm Cytoplasm, cytoskeleton Cell junction, adherens junction Cell projection, axon cleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=alpha N-catenin II; IsoId=Q61301-1; Sequence=Displayed; Name=2; Synonyms=alpha N-catenin I; IsoId=Q61301-2; Sequence=VSP_006734; Name=3; IsoId=Q61301-3; Sequence=VSP_038010, VSP_006734; Expressed almost exclusively in the nervous system. The ratio of the two isoforms changes during development; isoform 1 is more abundant than isoform 2 in earlier embryonic stages, whereas isoform 2 is predominant in the adult stage. Expressed in the ventricular zone and in neurons of the developing cortical plate (at protein level). Expressed in migrating neurons of the external granule cell layer at 13.5 dpc while expression appears in the Purkinje cell layer at 17.5 dpc (at protein level). Expressed postnatally in Purkinje cells and hippocampus (at protein level). Mice generally die within 24 hours after birth. They display altered Purkinje cells migration, unstable synaptic junctions, defective ventricular architecture, impaired axon migration, reduced number of neurons in specific nuclei, and disordered laminar formation. The cdf (cerebellar deficient folia) mice are viable but are ataxic and have cerebellar hypoplasia associated with abnormal lobulation of the cerebellum. They also display defects in Purkinje cells positioning and in packing density and lamination. Fear conditioning and prepulse inhibition of the startle response are altered in cdf mice. Those phenotypes are associated with alteration of the Ctnna2 gene which results in the C-terminal truncation of the protein and are rescued by expression of a Ctnna2 transgene (isoform 2). Belongs to the vinculin/alpha-catenin family. structural molecule activity nucleus cytoplasm cytoskeleton plasma membrane adherens junction cell-cell adherens junction cell adhesion multicellular organism development axonogenesis regulation of neuron projection development postsynaptic density actin cytoskeleton membrane basolateral plasma membrane radial glia guided migration of Purkinje cell lamellipodium cell junction cell differentiation axon negative regulation of Arp2/3 complex-mediated actin nucleation identical protein binding cell projection cadherin binding dendrite morphogenesis brain morphogenesis actin filament binding regulation of synapse structural plasticity prepulse inhibition cell-cell adhesion presynaptic active zone cytoplasmic component modification of postsynaptic actin cytoskeleton extrinsic component of presynaptic membrane extrinsic component of postsynaptic membrane postsynaptic density, intracellular component regulation of neuron migration uc291fxr.1 uc291fxr.2 
ENSMUST00000075341.4 Orm2 ENSMUST00000075341.4 orosomucoid 2 (from RefSeq NM_011016.2) A1AG2_MOUSE Agp-2 ENSMUST00000075341.1 ENSMUST00000075341.2 ENSMUST00000075341.3 NM_011016 Orm-2 P07361 uc008tga.1 uc008tga.2 uc008tga.3 Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction. Secreted. Expressed by the liver and secreted in plasma. Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation. Contains a beta-barrel that binds various ligands in its interior. Belongs to the calycin superfamily. Lipocalin family. regulation of immune system process extracellular region extracellular space acute-phase response uc008tga.1 uc008tga.2 uc008tga.3 
ENSMUST00000075351.10 Pip ENSMUST00000075351.10 prolactin induced protein (from RefSeq NM_008843.4) ENSMUST00000075351.1 ENSMUST00000075351.2 ENSMUST00000075351.3 ENSMUST00000075351.4 ENSMUST00000075351.5 ENSMUST00000075351.6 ENSMUST00000075351.7 ENSMUST00000075351.8 ENSMUST00000075351.9 NM_008843 Pip Q3UU48 Q3UU48_MOUSE uc009bqh.1 uc009bqh.2 uc009bqh.3 Monomer. Interacts with AZGP1. Secreted Belongs to the PIP family. extracellular region uc009bqh.1 uc009bqh.2 uc009bqh.3 
ENSMUST00000075363.10 Acot7 ENSMUST00000075363.10 acyl-CoA thioesterase 7, transcript variant 2 (from RefSeq NM_133348.2) A2A8K9 A2A8L0 A2A8L2 BACH_MOUSE Bach ENSMUST00000075363.1 ENSMUST00000075363.2 ENSMUST00000075363.3 ENSMUST00000075363.4 ENSMUST00000075363.5 ENSMUST00000075363.6 ENSMUST00000075363.7 ENSMUST00000075363.8 ENSMUST00000075363.9 NM_133348 Q3U8C6 Q59HQ2 Q91V12 uc008vzx.1 uc008vzx.2 uc008vzx.3 uc008vzx.4 Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (Probable). Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (Probable). May play an important physiological function in brain (Probable). Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence=; Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence=; Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=; Reaction=decanoyl-CoA + H2O = CoA + decanoate + H(+); Xref=Rhea:RHEA:40059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40060; Evidence=; Reaction=H2O + octanoyl-CoA = CoA + H(+) + octanoate; Xref=Rhea:RHEA:30143, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30144; Evidence=; Reaction=H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate; Xref=Rhea:RHEA:30139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30140; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40140; Evidence=; Kinetic parameters: KM=16 uM for palmitoyl-CoA (isoform A at 30 degrees Celsius) ; KM=12 uM for palmitoyl-CoA (isoform D at 30 degrees Celsius) ; Lipid metabolism; fatty acid metabolism. Homohexamer. Q91V12-2; Q91V12-2: Acot7; NbExp=5; IntAct=EBI-15642238, EBI-15642238; [Isoform A]: Cytoplasm, cytosol [Isoform D]: Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=4; Name=B; Synonyms=mBACHb; IsoId=Q91V12-1; Sequence=Displayed; Name=A; Synonyms=mBach, mBACHa, 43-kDa BACH; IsoId=Q91V12-2; Sequence=VSP_000158; Name=C; Synonyms=mBACHc; IsoId=Q91V12-3; Sequence=VSP_000157; Name=D; Synonyms=50-kDa BACH; IsoId=Q91V12-4; Sequence=VSP_016955; Widely expressed with highest levels in brain. High levels also found in thymus, large intestine and testis. Negligible in muscle and adipose tissue. In the central and peripheral nervous systems, displays a predominantly neuronal localization with highest expression in cell bodies and neurites. Detected in the brain as early as embryonic day (E) 11.5. The level was low until 12.5 dpc, but promptly elevated to a peak 7 days after birth. Thereafter, it declined somewhat and reached a steady-state level in adulthood. These changes in BACH expression were approximately reflected in the palmitoyl-CoA hydrolyzing activity in the developing mouse brain, and the time course was quite similar to that of microtubule-associated protein 2 (MAP2) expression. Induced during embryogenesis in association with neuronal differentiation, and persists after terminal differentiation into neurons in postnatal stages, resulting in the constitutive high expression of BACH in the adult brain in a neuron-specific manner. Up-Regulated in activated macrophages. Both HotDog ACOT-type hydrolase domains are required for efficient activity. [Isoform A]: Major isoform. fatty-acyl-CoA binding nucleoplasm cytoplasm cytosol lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process fatty acid catabolic process coenzyme A biosynthetic process palmitoyl-CoA hydrolase activity hydrolase activity thiolester hydrolase activity long-chain fatty acyl-CoA binding medium-chain fatty-acyl-CoA catabolic process long-chain fatty-acyl-CoA catabolic process identical protein binding protein homodimerization activity neuron projection cell body acyl-CoA hydrolase activity medium-chain fatty acid biosynthetic process carboxylic ester hydrolase activity palmitic acid biosynthetic process uc008vzx.1 uc008vzx.2 uc008vzx.3 uc008vzx.4 
ENSMUST00000075371.5 Vpreb1b ENSMUST00000075371.5 V-set pre-B cell surrogate light chain 1B (from RefSeq NM_016983.1) ENSMUST00000075371.1 ENSMUST00000075371.2 ENSMUST00000075371.3 ENSMUST00000075371.4 NM_016983 P13373 VPRE2_MOUSE Vpreb2 uc007ymq.1 uc007ymq.2 uc007ymq.3 Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B- cell differentiation. Only expressed by pre-B-cells. Belongs to the immunoglobulin superfamily. cell morphogenesis immunoglobulin production extracellular space immune response regulation of cell size B cell proliferation homeostasis of number of cells uc007ymq.1 uc007ymq.2 uc007ymq.3 
ENSMUST00000075374.10 Pard3b ENSMUST00000075374.10 par-3 family cell polarity regulator beta (from RefSeq NM_001081050.3) Als2cr19 ENSMUST00000075374.1 ENSMUST00000075374.2 ENSMUST00000075374.3 ENSMUST00000075374.4 ENSMUST00000075374.5 ENSMUST00000075374.6 ENSMUST00000075374.7 ENSMUST00000075374.8 ENSMUST00000075374.9 NM_001081050 PAR3L_MOUSE Par3l Q5SV53 Q9CSB4 uc007bfe.1 uc007bfe.2 uc007bfe.3 Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions (By similarity). Interacts with PARD6B. Interacts with INSC/inscuteable (By similarity). Q9CSB4; Q9WTK7: Stk11; NbExp=2; IntAct=EBI-16107395, EBI-8627450; Endomembrane system Cell junction Cell junction, tight junction Note=Partially localized along the cell-cell contact region. Colocalizes with TJP1 to epithelial tight junctions (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CSB4-1; Sequence=Displayed; Name=2; IsoId=Q9CSB4-2; Sequence=VSP_022017; [Isoform 2]: Sequence incomplete. Belongs to the PAR3 family. microtubule cytoskeleton organization protein binding nucleoplasm cytoplasm adherens junction cell-cell adherens junction bicellular tight junction cell cortex cell cycle cell adhesion protein localization endomembrane system membrane apical plasma membrane nuclear body establishment of cell polarity cell junction macromolecular complex phosphatidylinositol binding apical junction complex establishment or maintenance of epithelial cell apical/basal polarity cell division establishment of centrosome localization uc007bfe.1 uc007bfe.2 uc007bfe.3 
ENSMUST00000075387.11 Sez6l ENSMUST00000075387.11 seizure related 6 homolog like, transcript variant 2 (from RefSeq NM_019982.4) A0A0R4J0Y4 A0A0R4J0Y4_MOUSE ENSMUST00000075387.1 ENSMUST00000075387.10 ENSMUST00000075387.2 ENSMUST00000075387.3 ENSMUST00000075387.4 ENSMUST00000075387.5 ENSMUST00000075387.6 ENSMUST00000075387.7 ENSMUST00000075387.8 ENSMUST00000075387.9 NM_019982 Sez6l uc008ytk.1 uc008ytk.2 uc008ytk.3 uc008ytk.4 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc008ytk.1 uc008ytk.2 uc008ytk.3 uc008ytk.4 
ENSMUST00000075388.13 Gm10147 ENSMUST00000075388.13 predicted gene 10147 (from RefSeq NM_001099919.2) ENSMUST00000075388.1 ENSMUST00000075388.10 ENSMUST00000075388.11 ENSMUST00000075388.12 ENSMUST00000075388.2 ENSMUST00000075388.3 ENSMUST00000075388.4 ENSMUST00000075388.5 ENSMUST00000075388.6 ENSMUST00000075388.7 ENSMUST00000075388.8 ENSMUST00000075388.9 Gm10058 Gm10096 Gm10147 Gm10230 Gm10486 Gm10487 Gm14632 Gm14819 Gm4836 NM_001099919 Q62478 Q62478_MOUSE XMR uc009svz.1 uc009svz.2 uc009svz.3 uc009svz.4 uc009svz.5 uc009svz.6 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function nucleus spermatogenesis spermatid development meiotic cell cycle uc009svz.1 uc009svz.2 uc009svz.3 uc009svz.4 uc009svz.5 uc009svz.6 
ENSMUST00000075390.2 Or4k41 ENSMUST00000075390.2 olfactory receptor family 4 subfamily K member 41 (from RefSeq NM_001011773.1) ENSMUST00000075390.1 NM_001011773 Olfr1287 Or4k41 Q7TQY1 Q7TQY1_MOUSE uc008lnn.1 uc008lnn.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008lnn.1 uc008lnn.2 
ENSMUST00000075406.12 Szt2 ENSMUST00000075406.12 SZT2 subunit of KICSTOR complex (from RefSeq NM_198170.4) A2A9C3 ENSMUST00000075406.1 ENSMUST00000075406.10 ENSMUST00000075406.11 ENSMUST00000075406.2 ENSMUST00000075406.3 ENSMUST00000075406.4 ENSMUST00000075406.5 ENSMUST00000075406.6 ENSMUST00000075406.7 ENSMUST00000075406.8 ENSMUST00000075406.9 NM_198170 Q6PB77 Q7TSS6 SZT2_MOUSE Szt2 uc012djw.1 uc012djw.2 uc012djw.3 uc012djw.4 This gene encodes a protein associated with low seizure threshold in mice and may contribute to susceptibility to epilepsy. [provided by RefSeq, Aug 2011]. ##Evidence-Data-START## Transcript exon combination :: FJ998170.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids (By similarity). In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (PubMed:20045724). Part of the KICSTOR complex composed of KPTN, ITFG2, KICS2 and SZT2. SZT2 probably serves as a link between the other three proteins in the KICSTOR complex and may mediate the direct interaction with the GATOR complex via GATOR1. The KICSTOR complex interacts directly with the GATOR1 complex and most probably indirectly with the GATOR2 complex in an amino acid-independent manner. Lysosome membrane Peroxisome Note=Localization to lysosomes is amino acid-independent. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2A9C3-1; Sequence=Displayed; Name=2; IsoId=A2A9C3-2; Sequence=VSP_039917; Mostly expressed in brain, spinal cord and lung. Induced in cells resistant to glutamate toxicity. Knockout mice lacking Szt2 are born at an expected Mendelian ratio, but they do not survive weaning or any fasting (PubMed:28199315). They display increased mTORC1 signaling in several tissues (PubMed:28199306, PubMed:28199315). Mutant mice with a gene trap-induced truncating mutation display embryonic lethality and surviving mutants show significantly decreased threshold to minimal forebrain clonic seizures (PubMed:19624305). Sequence=AAH52935.1; Type=Frameshift; Evidence=; Sequence=AAH52935.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; Sequence=GU433214; Type=Frameshift; Evidence=; lysosome lysosomal membrane peroxisome central nervous system development post-embryonic development membrane corpus callosum morphogenesis response to nutrient levels cellular response to amino acid starvation cellular response to glucose starvation pigmentation protein localization to lysosome GATOR2 complex regulation of superoxide dismutase activity negative regulation of TORC1 signaling Iml1 complex uc012djw.1 uc012djw.2 uc012djw.3 uc012djw.4 
ENSMUST00000075418.15 Stard5 ENSMUST00000075418.15 StAR related lipid transfer domain containing 5 (from RefSeq NM_023377.4) ENSMUST00000075418.1 ENSMUST00000075418.10 ENSMUST00000075418.11 ENSMUST00000075418.12 ENSMUST00000075418.13 ENSMUST00000075418.14 ENSMUST00000075418.2 ENSMUST00000075418.3 ENSMUST00000075418.4 ENSMUST00000075418.5 ENSMUST00000075418.6 ENSMUST00000075418.7 ENSMUST00000075418.8 ENSMUST00000075418.9 NM_023377 Q9CQY0 Q9EPQ6 Q9EPQ7 STAR5_MOUSE uc009idq.1 uc009idq.2 uc009idq.3 May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. Expressed in most tissues, with highest levels in liver and in kidney. lipid transport lipid binding cholesterol binding bile acid binding cholesterol import uc009idq.1 uc009idq.2 uc009idq.3 
ENSMUST00000075420.6 Tmt1a3 ENSMUST00000075420.6 thiol methyltransferase 1A3 (from RefSeq NM_001081471.1) ENSMUST00000075420.1 ENSMUST00000075420.2 ENSMUST00000075420.3 ENSMUST00000075420.4 ENSMUST00000075420.5 G3X9G9 G3X9G9_MOUSE NM_001081471 Tmt1a3 uc007xqx.1 uc007xqx.2 uc007xqx.3 methyltransferase activity membrane integral component of membrane methylation uc007xqx.1 uc007xqx.2 uc007xqx.3 
ENSMUST00000075421.7 Krtap12-22 ENSMUST00000075421.7 predicted gene 10024 (from RefSeq NM_001081452.2) A0A0A0MQA4 A0A0A0MQA4_MOUSE ENSMUST00000075421.1 ENSMUST00000075421.2 ENSMUST00000075421.3 ENSMUST00000075421.4 ENSMUST00000075421.5 ENSMUST00000075421.6 Gm10024 NM_001081452 uc011xhj.1 uc011xhj.2 uc011xhj.3 uc011xhj.4 molecular_function cellular_component intermediate filament biological_process keratin filament uc011xhj.1 uc011xhj.2 uc011xhj.3 uc011xhj.4 
ENSMUST00000075422.6 Mab21l1 ENSMUST00000075422.6 mab-21-like 1 (from RefSeq NM_010750.3) ENSMUST00000075422.1 ENSMUST00000075422.2 ENSMUST00000075422.3 ENSMUST00000075422.4 ENSMUST00000075422.5 MB211_MOUSE Mab21 NM_010750 O70299 uc008pgv.1 uc008pgv.2 uc008pgv.3 uc008pgv.4 Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning (PubMed:11857508, PubMed:12642482). It is unclear whether it displays nucleotidyltransferase activity in vivo (By similarity). Binds single-stranded RNA (ssRNA) (By similarity). Monomer. Homodecamer; composed of 2 back to back homopentamers. The protein may exist as monomer in solution and oiligomerizes upon ligand binding. Nucleus Expressed in the adult cerebellum and eye, with lower levels in the adult forebrain. At 10 dpc, expressed in the temporal aspect of the retina and the anterior portion of the alar midbrain. At 10.5 dpc this retinal pattern of expression persists, with expression also beginning in the lens. Also expressed in the spinal cord, the optic cup, the presumptive lens and the genital ridge. Expressed in the dorsal midline, somites, and interdigital tissues from 9.5 dpc to 13.5 dpc. Expression is down-regulated by BMP2. Mice show eye and preputial gland defects (PubMed:12642482). Most male mice are sterile, but they can reproduce by in vitro fertilization (PubMed:12642482). Mice display calvarial ossification characterized by an unclosed calvarial region with impaired growth of fontanelle and parietal bones during postnatal development (PubMed:29156428). Belongs to the mab-21 family. nucleotide binding nucleus multicellular organism development positive regulation of cell proliferation transferase activity nucleotidyltransferase activity camera-type eye development metal ion binding uc008pgv.1 uc008pgv.2 uc008pgv.3 uc008pgv.4 
ENSMUST00000075444.8 Ddn ENSMUST00000075444.8 dendrin (from RefSeq NM_001013741.1) DEND_MOUSE ENSMUST00000075444.1 ENSMUST00000075444.2 ENSMUST00000075444.3 ENSMUST00000075444.4 ENSMUST00000075444.5 ENSMUST00000075444.6 ENSMUST00000075444.7 Gm748 Kiaa0749 NM_001013741 Q3TPT2 Q3TY46 Q80TS7 uc007xny.1 uc007xny.2 uc007xny.3 Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein. Forms a ternary complex with MAGI2 and SH3KBP1; recruits DDN to the cytoplasm (By similarity). Interacts with MAGI1 (By similarity). Interacts with ACTN1 and may interact with WWC1 (By similarity). Interacts with the podocyte slit diaphragm proteins CD2AP, NPHS1 and NPHS2; the interaction with CD2AP and NPHS1 is direct. Cell projection, dendritic spine membrane ; Peripheral membrane protein Cytoplasm. Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Perikaryon Nucleus. Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites. Two forms of 81 kDa and 89 kDa are expressed in brain. The 81 kDa form is the only one found in kidney podocytes. Expressed in the developing podocytes during glomerulogenesis. The 81 and 89 kDa forms are detected by an antibody raised against a C-terminal peptide arguing for alternative N-terminal sequences. Sequence=AAI57996.1; Type=Erroneous initiation; Evidence=; Sequence=AAI57997.1; Type=Erroneous initiation; Evidence=; Sequence=BAE34717.1; Type=Erroneous initiation; Evidence=; Sequence=EDL04165.1; Type=Erroneous initiation; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane membrane dendrite dendritic spine membrane cell projection perikaryon positive regulation of transcription from RNA polymerase II promoter uc007xny.1 uc007xny.2 uc007xny.3 
ENSMUST00000075447.14 Nectin2 ENSMUST00000075447.14 nectin cell adhesion molecule 2, transcript variant 1 (from RefSeq NM_008990.3) ENSMUST00000075447.1 ENSMUST00000075447.10 ENSMUST00000075447.11 ENSMUST00000075447.12 ENSMUST00000075447.13 ENSMUST00000075447.2 ENSMUST00000075447.3 ENSMUST00000075447.4 ENSMUST00000075447.5 ENSMUST00000075447.6 ENSMUST00000075447.7 ENSMUST00000075447.8 ENSMUST00000075447.9 Mph NECT2_MOUSE NM_008990 Nectin2 P32507 Pvr Pvrl2 Pvs Q62096 uc009fnd.1 uc009fnd.2 uc009fnd.3 Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. Can form trans-heterodimers with NECTIN3 (PubMed:10744716, PubMed:22902367). Interacts with CD226 or with PVRIG; these interactions are competitive and have a differential functional outcome on T-cell activation, either positive or negative, respectively. Binds with low affinity to TIGIT (By similarity). P32507-2; P32507-2: Nectin2; NbExp=3; IntAct=EBI-8844104, EBI-8844104; Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=Beta; IsoId=P32507-1; Sequence=Displayed; Name=Alpha; IsoId=P32507-2; Sequence=VSP_002630, VSP_002631; Brain, spinal cord, spleen, kidney, heart and liver. Belongs to the nectin family. acrosome assembly positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of immunoglobulin mediated immune response protein binding plasma membrane cell-cell junction zonula adherens cytoskeleton organization cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules spermatid development spermatid nucleus differentiation fertilization cell surface membrane integral component of membrane virion attachment to host cell fusion of virus membrane with host plasma membrane sperm mitochondrion organization cell part morphogenesis positive regulation of mast cell activation susceptibility to natural killer cell mediated cytotoxicity identical protein binding protein homodimerization activity apical junction complex cell-cell contact zone adhesion of symbiont to host cilium organization positive regulation of natural killer cell mediated cytotoxicity regulation of viral entry into host cell coreceptor-mediated virion attachment to host cell cell adhesion molecule binding positive regulation of T cell receptor signaling pathway establishment of mitochondrion localization susceptibility to T cell mediated cytotoxicity uc009fnd.1 uc009fnd.2 uc009fnd.3 
ENSMUST00000075448.13 Nfia ENSMUST00000075448.13 nuclear factor I/A, transcript variant 2 (from RefSeq NM_010905.3) ENSMUST00000075448.1 ENSMUST00000075448.10 ENSMUST00000075448.11 ENSMUST00000075448.12 ENSMUST00000075448.2 ENSMUST00000075448.3 ENSMUST00000075448.4 ENSMUST00000075448.5 ENSMUST00000075448.6 ENSMUST00000075448.7 ENSMUST00000075448.8 ENSMUST00000075448.9 NFIA_MOUSE NM_010905 P70250 P70251 Q02780 Q3UUZ2 Q61960 Q8VBT5 Q9R1G5 uc008ttu.1 uc008ttu.2 uc008ttu.3 uc008ttu.4 Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Binds DNA as a homodimer. Nucleus. Event=Alternative splicing; Named isoforms=7; Name=2; IsoId=Q02780-1; Sequence=Displayed; Name=1; IsoId=Q02780-2; Sequence=VSP_003537, VSP_003544; Name=3; IsoId=Q02780-3; Sequence=VSP_003538; Name=4; IsoId=Q02780-4; Sequence=VSP_003539; Name=5; IsoId=Q02780-5; Sequence=VSP_003537, VSP_003541; Name=6; IsoId=Q02780-6; Sequence=VSP_003540, VSP_003542, VSP_003543; Name=7; IsoId=Q02780-7; Sequence=VSP_003537; The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. [Isoform 4]: Incomplete sequence. [Isoform 5]: Incomplete sequence. [Isoform 6]: Incomplete sequence. Belongs to the CTF/NF-I family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm DNA replication regulation of transcription, DNA-templated transcription factor binding cell junction positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter synapse maturation ureter development uc008ttu.1 uc008ttu.2 uc008ttu.3 uc008ttu.4 
ENSMUST00000075452.7 Chic2 ENSMUST00000075452.7 cysteine-rich hydrophobic domain 2 (from RefSeq NM_028850.5) CHIC2_MOUSE ENSMUST00000075452.1 ENSMUST00000075452.2 ENSMUST00000075452.3 ENSMUST00000075452.4 ENSMUST00000075452.5 ENSMUST00000075452.6 NM_028850 Q0VG23 Q3T9U2 Q80ZT7 Q9D9G3 uc008xtw.1 uc008xtw.2 uc008xtw.3 uc008xtw.4 Membrane ; Peripheral membrane protein Golgi apparatus Note=Associated and found in vesicular structures of Golgi complex. Palmitoylation in the CHIC motif is required for membrane association. Belongs to the CHIC family. molecular_function Golgi apparatus Golgi-associated vesicle plasma membrane Golgi to plasma membrane transport membrane intracellular membrane-bounded organelle uc008xtw.1 uc008xtw.2 uc008xtw.3 uc008xtw.4 
ENSMUST00000075477.8 Cav3 ENSMUST00000075477.8 caveolin 3 (from RefSeq NM_007617.3) CAV3_MOUSE Cav3 ENSMUST00000075477.1 ENSMUST00000075477.2 ENSMUST00000075477.3 ENSMUST00000075477.4 ENSMUST00000075477.5 ENSMUST00000075477.6 ENSMUST00000075477.7 NM_007617 P51637 uc009dea.1 uc009dea.2 This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. The encoded protein is muscle-specific and forms homooligomers in muscle cells. The protein binds and regulates phosphofructokinase M and neuronal nitric oxide synthase. It also associates with dystrophin in muscle cells. Mutations in this gene are associated with muscular dystrophy. [provided by RefSeq, Apr 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024383.1, U36579.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (PubMed:19380584). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (By similarity). Homooligomer. Interacts with DYSF. Interacts with DLG1 and KCNA5; forms a ternary complex. Interacts with DAG1 (via its C- terminal); the interaction prevents binding of DAG1 with DMD (By similarity). Interacts with TRIM72 (PubMed:19380584). Interacts with MUSK; may regulate MUSK signaling (PubMed:19940021). Interacts with BVES (PubMed:24066022). Interacts with CAVIN1, CAVIN2 and CAVIN4 (By similarity). P51637; P18762: Adrb2; NbExp=2; IntAct=EBI-298576, EBI-491143; P51637; Q01815: Cacna1c; NbExp=4; IntAct=EBI-298576, EBI-644904; P51637; Q5SUG4: Cacna1g; NbExp=3; IntAct=EBI-298576, EBI-6918583; P51637; Q6PE92: Cacna1h; NbExp=5; IntAct=EBI-298576, EBI-6918775; Golgi apparatus membrane ; Peripheral membrane protein Cell membrane ; Peripheral membrane protein Membrane, caveola ; Peripheral membrane protein Cell membrane, sarcolemma Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). Expressed predominantly in muscle. Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2. Belongs to the caveolin family. Golgi membrane plasma membrane repair regulation of heart rate calcium channel regulator activity protein binding cytoplasm endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane caveola negative regulation of protein kinase activity triglyceride metabolic process endocytosis plasma membrane organization actin filament organization positive regulation of cytosolic calcium ion concentration myoblast fusion regulation of heart contraction protein C-terminus binding protein localization positive regulation of cell proliferation cell surface negative regulation of cardiac muscle hypertrophy positive regulation of myotube differentiation intercalated disc regulation of skeletal muscle contraction myotube differentiation dystrophin-associated glycoprotein complex membrane regulation of transforming growth factor beta receptor signaling pathway sodium channel regulator activity potassium channel inhibitor activity enzyme binding regulation of signaling Z disc cell differentiation T-tubule positive regulation of microtubule polymerization cytoplasmic microtubule organization membrane raft organization neuromuscular junction vesicle macromolecular complex detection of muscle stretch regulation of signal transduction by receptor internalization sarcolemma regulation of membrane potential glucose homeostasis cholesterol homeostasis alpha-tubulin binding intracellular membrane-bounded organelle negative regulation of MAP kinase activity negative regulation of MAPK cascade ion channel binding macromolecular complex binding membrane raft negative regulation of cell size muscle cell cellular homeostasis nitric-oxide synthase binding negative regulation of nitric-oxide synthase activity regulation of nerve growth factor receptor activity nucleus localization regulation of protein kinase B signaling regulation of calcium ion transport negative regulation of calcium ion transport cardiac muscle cell development regulation of cardiac muscle contraction binding, bridging negative regulation of sarcomere organization regulation of ventricular cardiac muscle cell membrane repolarization heart trabecula formation regulation of ventricular cardiac muscle cell membrane depolarization regulation of branching involved in mammary gland duct morphogenesis negative regulation of cell growth involved in cardiac muscle cell development caveola assembly connexin binding cellular response to organonitrogen compound protein localization to plasma membrane ventricular cardiac muscle cell action potential regulation of calcium ion import regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of p38MAPK cascade regulation of membrane depolarization during cardiac muscle cell action potential negative regulation of membrane depolarization during cardiac muscle cell action potential negative regulation of potassium ion transmembrane transporter activity regulation of calcium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transport regulation of sodium ion transmembrane transporter activity positive regulation of caveolin-mediated endocytosis focal adhesion uc009dea.1 uc009dea.2 
ENSMUST00000075483.5 Btnl6 ENSMUST00000075483.5 butyrophilin-like 6 (from RefSeq NM_030747.1) A2CG22 A2CG22_MOUSE Btnl6 EG624681 ENSMUST00000075483.1 ENSMUST00000075483.2 ENSMUST00000075483.3 ENSMUST00000075483.4 NM_030747 RP23-24A13.7-001 uc012aqb.1 uc012aqb.2 Membrane ; Single- pass type I membrane protein Belongs to the immunoglobulin superfamily. BTN/MOG family. receptor binding external side of plasma membrane membrane integral component of membrane extrathymic T cell selection regulation of immune response T cell receptor signaling pathway uc012aqb.1 uc012aqb.2 
ENSMUST00000075491.14 Fkbp8 ENSMUST00000075491.14 FK506 binding protein 8, transcript variant 1 (from RefSeq NM_001111066.1) ENSMUST00000075491.1 ENSMUST00000075491.10 ENSMUST00000075491.11 ENSMUST00000075491.12 ENSMUST00000075491.13 ENSMUST00000075491.2 ENSMUST00000075491.3 ENSMUST00000075491.4 ENSMUST00000075491.5 ENSMUST00000075491.6 ENSMUST00000075491.7 ENSMUST00000075491.8 ENSMUST00000075491.9 FKBP8_MOUSE Fkbp38 NM_001111066 O35465 Q3UK86 Q6GTX9 Q811M7 Q811R4 Q8C2F0 Q99L93 Sam11 uc009maq.1 uc009maq.2 uc009maq.3 uc009maq.4 Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl- X(L). Does not bind and inhibit calcineurin (By similarity). Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation (By similarity). Mitochondrion membrane ; Single-pass membrane protein ; Cytoplasmic side Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O35465-1; Sequence=Displayed; Name=2; IsoId=O35465-2; Sequence=VSP_034487; Detected throughout the embryonic body, in caudal neural tube, limbs and head. Detected in adult retina, brain, heart, kidney, liver, pancreas, lung, testis and urinary bladder (at protein level). Detected in adult brain, kidney, liver, testis and trigeminal nerve, and in embryo. Detected at lower levels in lung, spleen, heart and ovary. Widely expressed in forebrain. Detected in the Purkinje cell layer in the cerebellum and in hippocampus neurons. Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. Mice die shortly after birth. They display neural tube and skeletal defects. The neuroepithelium is disorganized and the formation of dorsal root ganglia is defective, likely as a result of an increased frequency of apoptosis and aberrant migration of neuronal cells. The extension of nerve fibers in the spinal cord is also abnormal. Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form. Sequence=AAB86422.1; Type=Erroneous initiation; Evidence=; Sequence=AAH03739.1; Type=Erroneous initiation; Evidence=; Sequence=AAH27808.1; Type=Erroneous initiation; Evidence=; Sequence=AAO27795.1; Type=Erroneous gene model prediction; Evidence=; Sequence=BAC40541.1; Type=Erroneous initiation; Evidence=; Sequence=BAE26916.1; Type=Erroneous initiation; Evidence=; Sequence=BAE31027.1; Type=Erroneous initiation; Evidence=; Sequence=BAE38118.1; Type=Erroneous initiation; Evidence=; Sequence=BAE39713.1; Type=Erroneous initiation; Evidence=; protein peptidyl-prolyl isomerization cell fate specification negative regulation of protein phosphorylation peptidyl-prolyl cis-trans isomerase activity mitochondrion mitochondrial envelope endoplasmic reticulum cytosol apoptotic process smoothened signaling pathway dorsal/ventral pattern formation regulation of gene expression membrane integral component of membrane isomerase activity dorsal/ventral neural tube patterning neural tube development integral component of endoplasmic reticulum membrane regulation of BMP signaling pathway positive regulation of BMP signaling pathway mitochondrial membrane macromolecular complex multicellular organism growth identical protein binding camera-type eye development negative regulation of apoptotic process disordered domain specific binding uc009maq.1 uc009maq.2 uc009maq.3 uc009maq.4 
ENSMUST00000075504.3 Defb39 ENSMUST00000075504.3 defensin beta 39 (from RefSeq NM_183038.3) A0A0R4J0Y8 A0A0R4J0Y8_MOUSE Defb39 ENSMUST00000075504.1 ENSMUST00000075504.2 NM_183038 uc009lab.1 uc009lab.2 Secreted extracellular region defense response uc009lab.1 uc009lab.2 
ENSMUST00000075510.12 Safb2 ENSMUST00000075510.12 scaffold attachment factor B2, transcript variant 8 (from RefSeq NM_001414454.1) ENSMUST00000075510.1 ENSMUST00000075510.10 ENSMUST00000075510.11 ENSMUST00000075510.2 ENSMUST00000075510.3 ENSMUST00000075510.4 ENSMUST00000075510.5 ENSMUST00000075510.6 ENSMUST00000075510.7 ENSMUST00000075510.8 ENSMUST00000075510.9 NM_001414454 Q80YR5 Q8K153 SAFB2_MOUSE uc008dcg.1 uc008dcg.2 uc008dcg.3 Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation (By similarity). Interacts with SAFB/SAFB1 and SCAM1. Interacts with SRPK1 and inhibits its activity. Cytoplasm Nucleus Sequence=AAH50855.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding RNA binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nuclear body identical protein binding intracellular membrane-bounded organelle sequence-specific DNA binding regulation of mRNA processing Sertoli cell differentiation regulation of androgen receptor signaling pathway uc008dcg.1 uc008dcg.2 uc008dcg.3 
ENSMUST00000075515.7 Serpinb9f ENSMUST00000075515.7 serine (or cysteine) peptidase inhibitor, clade B, member 9f (from RefSeq NM_183197.1) BC052216 ENSMUST00000075515.1 ENSMUST00000075515.2 ENSMUST00000075515.3 ENSMUST00000075515.4 ENSMUST00000075515.5 ENSMUST00000075515.6 NM_183197 Q80UK5 Q80UK5_MOUSE Serpinb9f uc007qag.1 uc007qag.2 uc007qag.3 Belongs to the serpin family. Ov-serpin subfamily. hematopoietic progenitor cell differentiation serine-type endopeptidase inhibitor activity extracellular space cytoplasm negative regulation of endopeptidase activity uc007qag.1 uc007qag.2 uc007qag.3 
ENSMUST00000075540.8 Mcm9 ENSMUST00000075540.8 Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross- links (ICLs) by homologous recombination (HR) (PubMed:23401855, PubMed:22771120). Required for DNA resection by the MRE11-RAD50- NBN/NBS1 (MRN) complex at double-stranded DNA breaks to generate ssDNA by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (By similarity). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:22771120, PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:22771120, PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (By similarity). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:21987787). Probably by regulating HR, plays a key role during gametogenesis (PubMed:21987787, PubMed:22771120). (from UniProt Q2KHI9) BC172624 ENSMUST00000075540.1 ENSMUST00000075540.2 ENSMUST00000075540.3 ENSMUST00000075540.4 ENSMUST00000075540.5 ENSMUST00000075540.6 ENSMUST00000075540.7 MCM9_MOUSE Mcmdc1 Q2KHI9 Q3V370 Q6P6J6 Q9D344 uc007fbq.1 uc007fbq.2 uc007fbq.3 uc007fbq.4 Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross- links (ICLs) by homologous recombination (HR) (PubMed:23401855, PubMed:22771120). Required for DNA resection by the MRE11-RAD50- NBN/NBS1 (MRN) complex at double-stranded DNA breaks to generate ssDNA by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (By similarity). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:22771120, PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:22771120, PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (By similarity). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:21987787). Probably by regulating HR, plays a key role during gametogenesis (PubMed:21987787, PubMed:22771120). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9 (PubMed:22771120). Interacts with the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1 (By similarity). Interacts with MLH1; the interaction recruits MLH1 to chromatin (By similarity). Interacts with MSH2; the interaction recruits MCM9 to chromatin (By similarity). Interacts with MSH6 (By similarity). Interacts with the MRN complex composed of MRE11, RAD50 and NBN/NBS1; the interaction recruits the MRN complex to DNA damage sites (By similarity). Interacts with RAD51; the interaction recruits RAD51 to DNA damage sites (By similarity). Nucleus Chromosome Note=Colocalizes to nuclear foci with RPA1 following DNA damage (PubMed:23401855). Localizes to double- stranded DNA breaks (By similarity). Recruited to chromatin by MSH2 (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Mcm9(L) ; IsoId=Q2KHI9-1; Sequence=Displayed; Name=2; IsoId=Q2KHI9-2; Sequence=VSP_028015; Name=3; Synonyms=Mcm9(S) ; IsoId=Q2KHI9-3; Sequence=VSP_028016, VSP_028017; Ubiquitously expressed. Expressed in embryos and adults. By E2F1 and serum stimulation. Females are viable but are sterile due to defects in double-strand break repair during gametogenesis. Males are not sterile and produce spermatozoa, but in much reduced quantity. Female ovaries are completely devoid of oocytes, and testes show a severe early proliferation defect of germ cells, causing a retarded development of only a fraction of seminiferous tubules that produce then apparently normal spermatozoa. [Isoform 3]: Incomplete sequence. Belongs to the MCM family. nucleotide binding double-strand break repair via homologous recombination DNA binding DNA helicase activity chromatin binding DNA replication origin binding single-stranded DNA binding helicase activity protein binding ATP binding nucleus chromosome DNA repair cellular response to DNA damage stimulus gamete generation female gamete generation hydrolase activity enzyme binding MutLbeta complex binding MutSalpha complex binding MutSbeta complex binding DNA duplex unwinding recombinational interstrand cross-link repair MCM complex macromolecular complex binding mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication protein localization to chromatin MCM8-MCM9 complex DNA replication uc007fbq.1 uc007fbq.2 uc007fbq.3 uc007fbq.4 
ENSMUST00000075550.4 Cenph ENSMUST00000075550.4 centromere protein H, transcript variant 1 (from RefSeq NM_021886.3) CENPH_MOUSE Cenph ENSMUST00000075550.1 ENSMUST00000075550.2 ENSMUST00000075550.3 Enp NM_021886 Q8R3K9 Q9D079 Q9D0N1 Q9QYM8 uc007rrn.1 uc007rrn.2 uc007rrn.3 Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate (By similarity). Self-associates. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS (By similarity). Interacts directly with CENPK (By similarity). Interacts with KIF2C and NDC80 (By similarity). Interacts with TRIM36. Nucleus Chromosome, centromere, kinetochore Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase. Abundantly expressed in thymus, spleen, uterus, ovary, testis and muscle, and weakly expressed in small intestine, lung and stomach. Barely detectable expression in kidney, liver, skin and prostate gland. Not detected in brain, heart or adrenal gland. Also expressed weakly in various hematopoietic cell lines. Abundantly expressed between embryonic day 9.5 and 12.5. Belongs to the CENP-H/MCM16 family. Sequence=BAB27505.1; Type=Frameshift; Evidence=; Sequence=BAB27810.1; Type=Frameshift; Evidence=; mitotic cell cycle chromosome, centromeric region kinetochore condensed chromosome kinetochore protein binding nucleus chromosome nucleolus chromosome segregation kinetochore binding kinetochore assembly kinetochore organization uc007rrn.1 uc007rrn.2 uc007rrn.3 
ENSMUST00000075552.7 Cyp2a12 ENSMUST00000075552.7 cytochrome P450, family 2, subfamily a, polypeptide 12 (from RefSeq NM_133657.1) CP2AC_MOUSE ENSMUST00000075552.1 ENSMUST00000075552.2 ENSMUST00000075552.3 ENSMUST00000075552.4 ENSMUST00000075552.5 ENSMUST00000075552.6 NM_133657 P56593 Q8VCW9 uc009fux.1 uc009fux.2 uc009fux.3 uc009fux.4 Highly active in the 7-alpha-hydroxylation of testosterone. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Liver. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity coumarin metabolic process membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding organelle membrane exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc009fux.1 uc009fux.2 uc009fux.3 uc009fux.4 
ENSMUST00000075558.5 H3c7 ENSMUST00000075558.5 H3 clustered histone 7 (from RefSeq NM_013548.4) A3KMN6 ENSMUST00000075558.1 ENSMUST00000075558.2 ENSMUST00000075558.3 ENSMUST00000075558.4 H3-143 H3-53 H3-B H3-F H3.2 H3.2-221 H3.2-614 H3.2-615 H3.2-616 H32_MOUSE H3b H3c13 H3c14 H3c15 H3c2 H3c3 H3c4 H3c6 H3c7 H3f Hist1h3b Hist1h3c Hist1h3d Hist1h3e Hist1h3f Hist2h3b Hist2h3c1 Hist2h3c2 Hist2h3ca1 Hist2h3ca2 NM_013548 P02295 P02297 P16105 P17269 P17320 P84228 Q60582 Q78E59 Q8CGN9 uc007ptz.1 uc007ptz.2 uc007ptz.3 uc007ptz.4 uc007ptz.5 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer (By similarity). Interacts with DNAJC9, CHAF1A and CHAF1B (By similarity). P84228; Q8TF76-1: HASPIN; Xeno; NbExp=3; IntAct=EBI-2658213, EBI-15815652; Nucleus. Chromosome. Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity). Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys- 10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H3 family. Sequence=AAH94041.1; Type=Erroneous initiation; Evidence=; Sequence=AAO06264.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter nuclear chromosome chromatin nucleosome nuclear nucleosome DNA binding chromatin binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly macromolecular complex protein heterodimerization activity protein heterotetramerization regulation of gene silencing uc007ptz.1 uc007ptz.2 uc007ptz.3 uc007ptz.4 uc007ptz.5 
ENSMUST00000075571.16 Sult2b1 ENSMUST00000075571.16 sulfotransferase family, cytosolic, 2B, member 1, transcript variant 1 (from RefSeq NM_017465.3) ENSMUST00000075571.1 ENSMUST00000075571.10 ENSMUST00000075571.11 ENSMUST00000075571.12 ENSMUST00000075571.13 ENSMUST00000075571.14 ENSMUST00000075571.15 ENSMUST00000075571.2 ENSMUST00000075571.3 ENSMUST00000075571.4 ENSMUST00000075571.5 ENSMUST00000075571.6 ENSMUST00000075571.7 ENSMUST00000075571.8 ENSMUST00000075571.9 NM_017465 O35400 Q8K472 Q91V03 ST2B1_MOUSE Sult2b uc009gxb.1 uc009gxb.2 uc009gxb.3 uc009gxb.4 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Preferentially sulfonates cholesterol (PubMed:12639899). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Cholesterol sulfation is approximately 10-fold higher than for pregnenolone and 20-fold higher than for DHEA (PubMed:12639899). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (By similarity). [Isoform 2]: Strongly sulfonates pregnenolone, however is capable to sulfonate cholesterol with a high degree of efficiency. DHEA is a relatively poor substrate. Reaction=3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'- bisphosphate + an alkyl sulfate + H(+); Xref=Rhea:RHEA:22552, ChEBI:CHEBI:15378, ChEBI:CHEBI:30879, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:83414; EC=2.8.2.2; Evidence=; Reaction=3'-phosphoadenylyl sulfate + pregnenolone = adenosine 3',5'- bisphosphate + H(+) + pregnenolone sulfate; Xref=Rhea:RHEA:52356, ChEBI:CHEBI:15378, ChEBI:CHEBI:16581, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:133000; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+); Xref=Rhea:RHEA:51216, ChEBI:CHEBI:15378, ChEBI:CHEBI:28689, ChEBI:CHEBI:57905, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343; Evidence=; Reaction=3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'- bisphosphate + cholesterol sulfate + H(+); Xref=Rhea:RHEA:52368, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136579; Evidence=; Kinetic parameters: KM=0.88 uM for cholesterol (isoform 2) ; KM=17.7 uM for pregnenolone (isoform 2) ; KM=0.87 uM for cholesterol (isoform 1) ; KM=16.7 uM for pregnenolone (isoform 1) ; KM=19.7 uM for 3beta-hydroxyandrost-5-en-17-one (DHEA)(isoform 1) ; Cytoplasm, cytosol Microsome Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SULT2B1b, B; IsoId=O35400-1; Sequence=Displayed; Name=2; Synonyms=SULT2B1a, A; IsoId=O35400-2; Sequence=VSP_012511; Expressed at high levels in epididymis, intestine and uterus, and low levels in brain and hypothalamus (PubMed:9647753). Isoform 2 is most prominent in the brain and spinal cord, with modest expression in the lung, skin and spleen (PubMed:12639899). Isoform 1 is most prominently expressed in skin and small intestine, with modest expression in muscle and prostate (PubMed:12639899). Isoform 1 and isoform 2 are expressed from stages 8.5-19 dpc. Belongs to the sulfotransferase 1 family. sulfate assimilation nucleic acid binding alcohol sulfotransferase activity nucleus cytoplasm endoplasmic reticulum cytosol lipid metabolic process sulfotransferase activity steroid metabolic process cholesterol metabolic process negative regulation of cell proliferation cholesterol binding transferase activity intracellular membrane-bounded organelle positive regulation of epidermal cell differentiation steroid sulfotransferase activity 3'-phosphoadenosine 5'-phosphosulfate metabolic process steroid hormone binding uc009gxb.1 uc009gxb.2 uc009gxb.3 uc009gxb.4 
ENSMUST00000075578.7 Abcb10 ENSMUST00000075578.7 ATP-binding cassette, sub-family B member 10 (from RefSeq NM_019552.2) ABCBA_MOUSE Abcb10 ENSMUST00000075578.1 ENSMUST00000075578.2 ENSMUST00000075578.3 ENSMUST00000075578.4 ENSMUST00000075578.5 ENSMUST00000075578.6 NM_019552 Q542P7 Q9D0C7 Q9JI39 uc009nwv.1 uc009nwv.2 This gene encodes a member of the ATP-binding cassette superfamily of transporters. ATP-binding cassette proteins transport various molecules across extra- and intra-cellular membranes. The encoded protein is localized to the mitochondrial inner membrane where it interacts with and stabilizes mitoferrin-1, and is important for heme biosynthesis. Additional evidence suggests the encoded protein is involved in oxidative stress protection and erythropoisesis. [provided by RefSeq, May 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC054793.1, AK081782.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164140, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 15215243; reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Catalyzes the export of an unknown physiological substrate from the mitochondrial matrix to the cytosol in an ATP-dependent manner (PubMed:26053025). May also transport the heme analog Zn (II) mesoporphyrin (ZnMP) in an ATP dependent manner but can't export the heme precursor 5-aminolevulinic acid (ALA) from mitochondria (PubMed:28808058, PubMed:26053025). Plays a role in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). In turn participates in hemoglobin synthesis and also protects against oxidative stress (PubMed:22240895, PubMed:28808058, PubMed:24421385). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (By similarity). Oxidized glutathione (GSSG) stimulates ATP hydrolysis without affecting ATP binding, whereas reduced glutathione (GSH) inhibits ATP binding and hydrolysis. Homodimer or homooligomer (PubMed:15215243, PubMed:30765471). Interacts with PAAT (By similarity). Interacts with SLC25A37; this interaction stabilizes SLC25A37 and enhances the function of SLC25A37 to import mitochondrial iron during erythroid differentiation (PubMed:19805291). Interacts with FECH; this interaction may allow the formation of an oligomeric complex with SLC25A37 (PubMed:20427704). Forms a complex with ABCB7 and FECH, where a dimeric FECH bridges ABCB7 and ABCB10 homodimers; this complex may be required for cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). Interacts with FECH (By similarity). Mitochondrion inner membrane ; Multi-pass membrane protein Expressed at particularly high levels in fetal liver, and erythroid tissues of embryos and adults. Found also in adult bone marrow, liver and kidney, and at lower levels in heart, brain and spleen. Abundant in the liver but not in non-hematopoietic tissues of 13 dpc embryos. By transcription factor GATA-1 during erythroid differentiation and in vitro, by DMSO during terminal erythroid maturation. Induced during cell erythroid differentiation (PubMed:20427704). Homozygous knockout mice for ABCB10 are embryonic lethal and embryos are pale and die between 10.5 and 11.5 dpc because of embryonic hematopoietic failure (PubMed:24421385, PubMed:22240895). Embryos are completely resorbed by the uterus by 13.5 dpc and present severe anemia at 10.5 dpc (PubMed:22240895). Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily. nucleotide binding protein binding ATP binding mitochondrion mitochondrial inner membrane membrane integral component of membrane ATPase activity integral component of mitochondrial membrane ATPase activity, coupled to transmembrane movement of substances protein homodimerization activity transmembrane transport uc009nwv.1 uc009nwv.2 
ENSMUST00000075595.3 Or56b1b ENSMUST00000075595.3 olfactory receptor family 56 subfamily B member 1B (from RefSeq NM_001011858.1) ENSMUST00000075595.1 ENSMUST00000075595.2 NM_001011858 Olfr504 Or56b1b Q7TRU7 Q7TRU7_MOUSE uc009jco.1 uc009jco.2 uc009jco.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC104310.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jco.1 uc009jco.2 uc009jco.3 
ENSMUST00000075602.8 Hmgn2-ps ENSMUST00000075602.8 Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. (from UniProt Q5BL14) ENSMUST00000075602.1 ENSMUST00000075602.2 ENSMUST00000075602.3 ENSMUST00000075602.4 ENSMUST00000075602.5 ENSMUST00000075602.6 ENSMUST00000075602.7 Hmgn2 Q5BL14 Q5BL14_MOUSE uc292azz.1 uc292azz.2 Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Nucleus Belongs to the HMGN family. chromatin nucleus nucleosomal DNA binding uc292azz.1 uc292azz.2 
ENSMUST00000075603.5 Glra1 ENSMUST00000075603.5 glycine receptor, alpha 1 subunit, transcript variant 1 (from RefSeq NM_001290821.1) ENSMUST00000075603.1 ENSMUST00000075603.2 ENSMUST00000075603.3 ENSMUST00000075603.4 GLRA1_MOUSE NM_001290821 Q5NCT8 Q64018 Q64019 Q9R0Y6 Q9R0Y7 uc007izo.1 uc007izo.2 uc007izo.3 uc007izo.4 Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:16672662, PubMed:17114051, PubMed:24801766). Channel opening is also triggered by taurine and beta-alanine (By similarity). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (By similarity). Plays an important role in the down-regulation of neuronal excitability (PubMed:9145798). Contributes to the generation of inhibitory postsynaptic currents (PubMed:16672662, PubMed:17114051, PubMed:24801766). Channel activity is potentiated by ethanol. Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (PubMed:24801766). Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence= Inhibited by strychnine. Inhibited by picrotoxin (PubMed:16672662). Channel activity is enhanced by 5 uM Zn(2+) and inhibited by 100 uM Zn(2+) (PubMed:17114051). Homopentamer (in vitro). Interacts with GLRB to form heteropentameric channels; this is probably the predominant form in vivo. Heteropentamer composed of two GLRA1 and three GLRB. Heteropentamer composed of three GLRA1 and two GLRB. Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different. Interacts with GLRB (By similarity). Postsynaptic cell membrane ulti-pass membrane protein Synapse rikaryon Cell projection, dendrite Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=a; Synonyms=Long; IsoId=Q64018-1; Sequence=Displayed; Name=b; Synonyms=Short; IsoId=Q64018-2; Sequence=VSP_000080; Detected in spinal cord neurons (PubMed:9145798, PubMed:17114051, PubMed:24801766). Detected in brain stem neurons (PubMed:16672662, PubMed:24801766). Detected at lower levels in hippocampus and cerebellum (PubMed:24801766). Detected in the inner plexiform layer of the retina (at protein level) (PubMed:12975813). The channel pore is formed by pentameric assembly of the second transmembrane domain from all five subunits. Channel opening is effected by an outward rotation of the transmembrane domains that increases the diameter of the pore. Note=Defects in Glra1 are the cause of the spasmodic (spd) phenotype, a mouse mutant which resembles the human neurological disease, hyperekplexia (or startle disease (STHE)) (PubMed:7920629). Defects in Glra1 are the cause of the lethal oscillator (spd-ot) phenotype. Mutant mice display a fine motor tremor and muscle spasms that begin at 2 weeks of age and progressively worsen, resulting in death by 3 weeks of age (PubMed:7874121). Heterozygous mice show an increased acoustic startle response (PubMed:9145798). Neurons from homozygous oscillator mice have dramatically reduced amplitude and frequency of glycinergic inhibitory postsynaptic currents (PubMed:16672662). The oscillator phenotype is due to the complete absence of Glra1 protein (PubMed:9145798). The alpha subunit binds strychnine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily. action potential startle response regulation of respiratory gaseous exchange by neurological system process transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity chloride channel activity endoplasmic reticulum plasma membrane integral component of plasma membrane ion transport anion transport chloride transport muscle contraction signal transduction neuropeptide signaling pathway chemical synaptic transmission acrosome reaction visual perception adult walking behavior zinc ion binding external side of plasma membrane membrane integral component of membrane glycine binding extracellular-glycine-gated ion channel activity extracellular-glycine-gated chloride channel activity transmitter-gated ion channel activity cell junction dendrite taurine binding ion transmembrane transport chloride channel complex regulation of membrane potential identical protein binding cell projection neuron projection neuronal cell body response to amino acid perikaryon intracellular membrane-bounded organelle regulation of respiratory gaseous exchange calyx of Held synapse postsynaptic membrane metal ion binding neurological system process neuromuscular process controlling posture neuromuscular process protein homooligomerization protein heterooligomerization negative regulation of transmission of nerve impulse synaptic transmission, glycinergic righting reflex inhibitory synapse excitatory postsynaptic potential inhibitory postsynaptic potential cellular response to amino acid stimulus cellular response to zinc ion cellular response to ethanol response to alcohol integral component of presynaptic membrane integral component of postsynaptic specialization membrane chloride transmembrane transport transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential positive regulation of acrosome reaction uc007izo.1 uc007izo.2 uc007izo.3 uc007izo.4 
ENSMUST00000075606.6 Ehbp1l1 ENSMUST00000075606.6 EH domain binding protein 1-like 1, transcript variant D (from RefSeq NM_001114596.1) ENSMUST00000075606.1 ENSMUST00000075606.2 ENSMUST00000075606.3 ENSMUST00000075606.4 ENSMUST00000075606.5 Ehbp1l1 G5E8Y6 G5E8Y6_MOUSE NM_001114596 uc008gex.1 uc008gex.2 uc008gex.3 uc008gex.4 uc008gex.5 uc008gex.6 uc008gex.1 uc008gex.2 uc008gex.3 uc008gex.4 uc008gex.5 uc008gex.6 
ENSMUST00000075610.13 Pstk ENSMUST00000075610.13 phosphoseryl-tRNA kinase, transcript variant 2 (from RefSeq NM_001364161.1) ENSMUST00000075610.1 ENSMUST00000075610.10 ENSMUST00000075610.11 ENSMUST00000075610.12 ENSMUST00000075610.2 ENSMUST00000075610.3 ENSMUST00000075610.4 ENSMUST00000075610.5 ENSMUST00000075610.6 ENSMUST00000075610.7 ENSMUST00000075610.8 ENSMUST00000075610.9 NM_001364161 PSTK_MOUSE Q0D2I7 Q14C09 Q8BP74 uc009kbh.1 uc009kbh.2 uc009kbh.3 uc009kbh.4 Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis. No activity with other tRNAs has been detected. Reaction=ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec); Xref=Rhea:RHEA:25037, Rhea:RHEA-COMP:9742, Rhea:RHEA-COMP:9947, ChEBI:CHEBI:30616, ChEBI:CHEBI:78533, ChEBI:CHEBI:78551, ChEBI:CHEBI:456216; EC=2.7.1.164; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 1/2. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BP74-1; Sequence=Displayed; Name=2; IsoId=Q8BP74-2; Sequence=VSP_024860; Belongs to the L-seryl-tRNA(Sec) kinase family. tRNA binding nucleotide binding selenocysteine incorporation ATP binding mitochondrion cytosol translation kinase activity phosphorylation transferase activity selenocysteinyl-tRNA(Sec) biosynthetic process uc009kbh.1 uc009kbh.2 uc009kbh.3 uc009kbh.4 
ENSMUST00000075619.5 Slc22a27 ENSMUST00000075619.5 solute carrier family 22, member 27, transcript variant 1 (from RefSeq NM_134256.1) ENSMUST00000075619.1 ENSMUST00000075619.2 ENSMUST00000075619.3 ENSMUST00000075619.4 NM_134256 Oat9 Q76M71 Q76M72 S22AR_MOUSE Slc22a27 uc008gls.1 uc008gls.2 uc008gls.3 [Isoform 1]: Does not appear to have transporter activity. [Isoform 2]: Sodium-independent organic anion transporter which exhibits high specificity for L-carnitine. Can also transport salicylic acid and the drug cimetidine. Kinetic parameters: KM=2.8 uM for L-carnitine (isoform 2) ; KM=16.1 uM for cimetidine (isoform 2) ; KM=175.5 uM for salicylic acid (isoform 2) ; Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=L ; IsoId=Q76M72-1; Sequence=Displayed; Name=2; Synonyms=S ; IsoId=Q76M72-2; Sequence=VSP_058421; Expressed in proximal kidney tubules, and in liver hepatocytes (at protein level). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. plasma membrane organic anion transport membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008gls.1 uc008gls.2 uc008gls.3 
ENSMUST00000075637.11 Ptpn3 ENSMUST00000075637.11 protein tyrosine phosphatase, non-receptor type 3, transcript variant 1 (from RefSeq NM_011207.2) A2ALK8 ENSMUST00000075637.1 ENSMUST00000075637.10 ENSMUST00000075637.2 ENSMUST00000075637.3 ENSMUST00000075637.4 ENSMUST00000075637.5 ENSMUST00000075637.6 ENSMUST00000075637.7 ENSMUST00000075637.8 ENSMUST00000075637.9 NM_011207 PTN3_MOUSE uc008sya.1 uc008sya.2 uc008sya.3 May act at junctions between the membrane and the cytoskeleton. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. phosphotyrosine binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytoplasm cytoskeleton plasma membrane protein dephosphorylation cytoskeletal protein binding cytoplasmic side of plasma membrane membrane dephosphorylation hydrolase activity phosphatase activity sodium channel regulator activity peptidyl-tyrosine dephosphorylation negative regulation of mitotic cell cycle negative regulation of membrane protein ectodomain proteolysis ATPase binding liver regeneration regulation of membrane depolarization during action potential regulation of sodium ion transmembrane transporter activity uc008sya.1 uc008sya.2 uc008sya.3 
ENSMUST00000075639.11 Lrmda ENSMUST00000075639.11 leucine rich melanocyte differentiation associated (from RefSeq NM_028275.1) ENSMUST00000075639.1 ENSMUST00000075639.10 ENSMUST00000075639.2 ENSMUST00000075639.3 ENSMUST00000075639.4 ENSMUST00000075639.5 ENSMUST00000075639.6 ENSMUST00000075639.7 ENSMUST00000075639.8 ENSMUST00000075639.9 LRMDA_MOUSE Lrmda NM_028275 Q9D9B4 uc007slz.1 uc007slz.2 uc007slz.3 uc007slz.4 Required for melanocyte differentiation. molecular_function cellular_component cell differentiation melanocyte differentiation uc007slz.1 uc007slz.2 uc007slz.3 uc007slz.4 
ENSMUST00000075641.10 Npm1 ENSMUST00000075641.10 nucleophosmin 1, transcript variant 1 (from RefSeq NM_008722.3) ENSMUST00000075641.1 ENSMUST00000075641.2 ENSMUST00000075641.3 ENSMUST00000075641.4 ENSMUST00000075641.5 ENSMUST00000075641.6 ENSMUST00000075641.7 ENSMUST00000075641.8 ENSMUST00000075641.9 NM_008722 NPM_MOUSE Q61937 uc007ikd.1 uc007ikd.2 uc007ikd.3 uc007ikd.4 Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (PubMed:20513429). Decamer formed by two pentameric rings associated in a head- to-head fashion. Disulfide-linked dimers under certain conditions. Interacts with NSUN2 and SENP3 (By similarity). The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with the methylated form of RPS10. Interacts (via N-terminal domain) with APEX1; the interaction is RNA-dependent and decreases peroxide-damaged cells. Interacts with NEK2. Interacts with ROCK2 and BRCA2 (By similarity). Interacts with RPGR. Interacts with CENPW (By similarity). Interacts with EIF2AK2/PKR. Interacts with DDX31; this interaction prevents interaction between NPM1 and HDM2 (By similarity). Interacts with MYC; competitive with NOP53. Interacts with NOP53; the interaction is direct and competitive with MYC (By similarity). Interacts with LRRC34 (PubMed:24991885). Interacts with RRP1B (By similarity). Interacts with NPM3 (By similarity). Interacts with ALKBH2. Interacts with TTF1 (via C-terminal region) (PubMed:20513429). Q61937; Q00987: MDM2; Xeno; NbExp=2; IntAct=EBI-626362, EBI-389668; Nucleus, nucleolus Nucleus, nucleoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Colocalizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. NEK2 is required for its localization to the centrosome during mitosis (By similarity). Expressed in B-cells that have been induced to switch to various Ig isotypes. Acetylated at C-terminal lysine residues, thereby increasing affinity to histones. ADP-ribosylated. Phosphorylated at Ser-4 by PLK1 and PLK2. Phosphorylation at Ser-4 by PLK2 in S phase is required for centriole duplication and is sufficient to trigger centriole replication. Phosphorylation at Ser-4 by PLK1 takes place during mitosis. Phosphorylated by CDK2 at Ser-125 and Thr-198. Phosphorylation at Thr-198 may trigger initiation of centrosome duplication. Phosphorylated by CDK1 at Thr-198, Thr-217, Thr-232 and Thr-235 during cell mitosis. When these four sites are phosphorated, RNA-binding activity seem to be abolished. May be phosphorylated at Ser-70 by NEK2. The Thr-198 phosphorylated form has higher affinity for ROCK2 (By similarity). Sumoylated by ARF. Ubiquitinated. Ubiquitination leads to proteasomal degradation. Deubiquitinated by USP36. Belongs to the nucleoplasmin family. ribosomal large subunit export from nucleus ribosomal small subunit export from nucleus cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) core promoter binding regulation of cell growth granular component p53 binding nucleic acid binding DNA binding chromatin binding transcription coactivator activity RNA binding protein kinase inhibitor activity protein binding ATP binding phosphatidylinositol-3,4,5-trisphosphate binding nucleus nucleoplasm nucleolus cytoplasm centrosome microtubule organizing center cytosol cytoskeleton DNA repair nucleosome assembly chromatin remodeling rRNA export from nucleus cell volume homeostasis nucleocytoplasmic transport centrosome cycle cell aging protein localization transcription factor binding positive regulation of cell proliferation negative regulation of cell proliferation rRNA transcription posttranscriptional regulation of gene expression negative regulation of gene expression negative regulation of cardiac muscle cell apoptotic process regulation of centrosome duplication positive regulation of centrosome duplication negative regulation of centrosome duplication large ribosomal subunit small ribosomal subunit nuclear matrix nuclear speck rRNA binding enzyme binding protein kinase binding Tat protein binding positive regulation of cellular biosynthetic process positive regulation of protein ubiquitination spindle pole centrosome regulation of protein stability regulation of endodeoxyribonuclease activity macromolecular complex protein-DNA complex activating transcription factor binding cellular response to UV ribosomal large subunit biogenesis ribosomal small subunit biogenesis histone binding identical protein binding protein homodimerization activity ribosomal large subunit binding ribosomal small subunit binding negative regulation of apoptotic process positive regulation of catalytic activity protein kinase B binding regulation of DNA damage response, signal transduction by p53 class mediator regulation of neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of protein kinase activity by regulation of protein phosphorylation positive regulation of translation positive regulation of DNA replication positive regulation of protein kinase activity positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of centriole replication protein heterodimerization activity protein N-terminus binding negative regulation of mRNA splicing, via spliceosome negative regulation of epithelial cell proliferation protein stabilization positive regulation of DNA metabolic process NF-kappaB binding unfolded protein binding positive regulation of NF-kappaB transcription factor activity protein homooligomerization regulation of cell cycle regulation of endoribonuclease activity regulation of eIF2 alpha phosphorylation by dsRNA positive regulation of DNA-directed DNA polymerase activity regulation of mRNA stability involved in cellular response to UV positive regulation of cell cycle G2/M phase transition positive regulation of protein localization to nucleolus ribonucleoprotein complex uc007ikd.1 uc007ikd.2 uc007ikd.3 uc007ikd.4 
ENSMUST00000075648.4 Rnase2b ENSMUST00000075648.4 ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin) (from RefSeq NM_019398.2) ENSMUST00000075648.1 ENSMUST00000075648.2 ENSMUST00000075648.3 NM_019398 Raf4 Rnase2b W0UVC5 W0UVC5_MOUSE uc007tmt.1 uc007tmt.2 uc007tmt.3 Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity hydrolase activity nucleic acid phosphodiester bond hydrolysis uc007tmt.1 uc007tmt.2 uc007tmt.3 
ENSMUST00000075654.2 1700020N15Rik ENSMUST00000075654.2 RIKEN cDNA 1700020N15 gene (from RefSeq NR_177970.1) 1700020N15Rik ENSMUST00000075654.1 L7MTX3 L7MTX3_MOUSE NR_177970 uc009tjd.1 uc009tjd.2 uc009tjd.3 uc009tjd.4 molecular_function cellular_component biological_process uc009tjd.1 uc009tjd.2 uc009tjd.3 uc009tjd.4 
ENSMUST00000075657.8 Ap3s2 ENSMUST00000075657.8 adaptor-related protein complex 3, sigma 2 subunit (from RefSeq NM_009682.3) AP3S2_MOUSE ENSMUST00000075657.1 ENSMUST00000075657.2 ENSMUST00000075657.3 ENSMUST00000075657.4 ENSMUST00000075657.5 ENSMUST00000075657.6 ENSMUST00000075657.7 NM_009682 O09077 O09149 Q3UDG7 Q8BSZ2 Q8CAY1 Q99589 uc009hzf.1 uc009hzf.2 uc009hzf.3 uc009hzf.4 Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). AP- 3 associates with the BLOC-1 complex. Interacts with AGAP1. Golgi apparatus. Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Present in all adult tissues examined. Belongs to the adaptor complexes small subunit family. Golgi apparatus trans-Golgi network intracellular protein transport anterograde axonal transport protein transport membrane vesicle-mediated transport membrane coat AP-3 adaptor complex cytoplasmic vesicle membrane cytoplasmic vesicle intracellular membrane-bounded organelle anterograde synaptic vesicle transport axon cytoplasm uc009hzf.1 uc009hzf.2 uc009hzf.3 uc009hzf.4 
ENSMUST00000075671.5 Nfatc2ip ENSMUST00000075671.5 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein, transcript variant 1 (from RefSeq NM_010900.4) ENSMUST00000075671.1 ENSMUST00000075671.2 ENSMUST00000075671.3 ENSMUST00000075671.4 NF2IP_MOUSE NM_010900 Nip45 O09130 Q8CDG2 Q9CVY5 uc009jra.1 uc009jra.2 In T-helper 2 (Th2) cells, regulates the magnitude of NFAT- driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly- SUMO chains by UBE2I/UBC9. Interacts with NFATC2, TRAF1, TRAF2 and PRMT1. Interacts with UBE2I/UBC9. Nucleus. Cytoplasm. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus. Highest level detected in spleen, thymus and testis. Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production. Mutant mice are born at the expected Mendelian ratio and appear healthy and viable. No alteration in thymic T-cell populations, T-cell proliferation, or peripheral lymphocyte development. Inefficient type-2 antiparasitic immune response to the intestinal nematode Trichinella spiralis due to impaired IL4 and IL13 cytokine production by Th2 cells. Sequence=BAB24331.1; Type=Frameshift; Evidence=; cytokine production nucleus cytoplasm positive regulation of transcription from RNA polymerase II promoter uc009jra.1 uc009jra.2 
ENSMUST00000075675.7 Methig1 ENSMUST00000075675.7 methyltransferase hypoxia inducible domain containing 1 (from RefSeq NM_001024672.3) ENSMUST00000075675.1 ENSMUST00000075675.2 ENSMUST00000075675.3 ENSMUST00000075675.4 ENSMUST00000075675.5 ENSMUST00000075675.6 LOC554292 Methig1 NM_001024672 Q76I26 Q76I26_MOUSE UbiE-YGHL1(HIG1-4) UbiE2-Hig1-4 uc007xra.1 uc007xra.2 uc007xra.3 molecular_function cellular_component biological_process methyltransferase activity membrane integral component of membrane methylation uc007xra.1 uc007xra.2 uc007xra.3 
ENSMUST00000075686.7 Ado ENSMUST00000075686.7 2-aminoethanethiol dioxygenase (from RefSeq NM_001005419.2) AEDO_MOUSE ENSMUST00000075686.1 ENSMUST00000075686.2 ENSMUST00000075686.3 ENSMUST00000075686.4 ENSMUST00000075686.5 ENSMUST00000075686.6 Gm237 NM_001005419 Q3U2E1 Q6PDY2 uc007flz.1 uc007flz.2 uc007flz.3 uc007flz.4 Plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate (PubMed:17581819, PubMed:32601061). Catalyzes the oxidation of cysteamine (2-aminoethanethiol) to hypotaurine (PubMed:17581819, PubMed:32601061). Catalyzes the oxidation of the regulator of G-protein signaling 5 (RGS5) (PubMed:32601061). Also oxidizes proteins RGS4 and interleukin-32 (IL32) (By similarity). Reaction=cysteamine + O2 = H(+) + hypotaurine; Xref=Rhea:RHEA:14409, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57853, ChEBI:CHEBI:58029; EC=1.13.11.19; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14410; Evidence=; Reaction=N-terminal L-cysteinyl-[protein] + O2 = H(+) + N-terminal S- hydroxy-S-oxy-L-cysteinyl-[protein]; Xref=Rhea:RHEA:70895, Rhea:RHEA- COMP:12707, Rhea:RHEA-COMP:17973, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:65250, ChEBI:CHEBI:156254; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70896; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Kinetic parameters: KM=3.8 mM for cysteamine ; Vmax=2300 nmol/min/mg enzyme for cysteamine ; Monomer. Ubiquitous, with highest expression in brain, heart and skeletal muscle (at protein level). Sequence=AAH57106.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH58407.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding mitochondrion oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen metal ion binding cysteamine dioxygenase activity dioxygenase activity oxidation-reduction process uc007flz.1 uc007flz.2 uc007flz.3 uc007flz.4 
ENSMUST00000075689.7 Parp10 ENSMUST00000075689.7 poly (ADP-ribose) polymerase family, member 10, transcript variant 1 (from RefSeq NM_001163575.1) ENSMUST00000075689.1 ENSMUST00000075689.2 ENSMUST00000075689.3 ENSMUST00000075689.4 ENSMUST00000075689.5 ENSMUST00000075689.6 F6Z9X8 NM_001163575 PAR10_MOUSE Parp10 Q3TLV7 Q3U6C0 Q8BSZ1 Q8C8L6 Q8CIE4 Q8R133 Q8R1U9 uc007wjk.1 uc007wjk.2 uc007wjk.3 uc007wjk.4 ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA. Reaction=L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L- lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58220, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:15088, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:142515; Evidence=; Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA- COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=; Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence=; Interacts with MYC. Interacts with PARP14. Interacts (via-PIP box and ubiquitin-interacting motifs) with PCNA. Cytoplasm Nucleus Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1- dependent manner. The PIP-box mediates the interaction with PCNA. Stimulated through its phosphorylation by CDK2. Acquires CDK- dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells. Auto-mono-ADP-ribosylated on glutamate and lysine residues. Belongs to the ARTD/PARP family. Sequence=AAH25608.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC32856.1; Type=Frameshift; Evidence=; NAD+ ADP-ribosyltransferase activity nucleus nucleolus cytoplasm cytosol DNA repair protein ADP-ribosylation cellular response to DNA damage stimulus negative regulation of gene expression regulation of chromatin assembly transferase activity transferase activity, transferring glycosyl groups translesion synthesis negative regulation of NF-kappaB transcription factor activity intracellular membrane-bounded organelle negative regulation of viral genome replication negative regulation of fibroblast proliferation protein poly-ADP-ribosylation protein auto-ADP-ribosylation K63-linked polyubiquitin binding negative regulation of protein K63-linked ubiquitination protein ADP-ribosylase activity uc007wjk.1 uc007wjk.2 uc007wjk.3 uc007wjk.4 
ENSMUST00000075693.12 Yipf1 ENSMUST00000075693.12 Yip1 domain family, member 1, transcript variant 1 (from RefSeq NM_145550.3) ENSMUST00000075693.1 ENSMUST00000075693.10 ENSMUST00000075693.11 ENSMUST00000075693.2 ENSMUST00000075693.3 ENSMUST00000075693.4 ENSMUST00000075693.5 ENSMUST00000075693.6 ENSMUST00000075693.7 ENSMUST00000075693.8 ENSMUST00000075693.9 NM_145550 Q3TZU1 Q91VU1 YIPF1_MOUSE uc008tzs.1 uc008tzs.2 uc008tzs.3 uc008tzs.4 Interacts with YIPF6; this interaction may stabilize YIPF1. May also form a ternary complex with YIPF2 and YIPF6. Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane Late endosome membrane Note=Mainly localizes within medial-/trans-Golgi and trans-Golgi network (TGN), while less so within cis-Golgi. Belongs to the YIP1 family. Golgi trans cisterna endosome Golgi apparatus Golgi medial cisterna trans-Golgi network membrane integral component of membrane vesicle-mediated transport Rab GTPase binding transport vesicle late endosome membrane uc008tzs.1 uc008tzs.2 uc008tzs.3 uc008tzs.4 
ENSMUST00000075717.7 Or7e177 ENSMUST00000075717.7 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PX82) E9PX82 E9PX82_MOUSE ENSMUST00000075717.1 ENSMUST00000075717.2 ENSMUST00000075717.3 ENSMUST00000075717.4 ENSMUST00000075717.5 ENSMUST00000075717.6 Olfr873 Or7e177 uc292evj.1 uc292evj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292evj.1 uc292evj.2 
ENSMUST00000075724.9 Rfxank ENSMUST00000075724.9 regulatory factor X-associated ankyrin-containing protein, transcript variant 2 (from RefSeq NM_001025589.1) ENSMUST00000075724.1 ENSMUST00000075724.2 ENSMUST00000075724.3 ENSMUST00000075724.4 ENSMUST00000075724.5 ENSMUST00000075724.6 ENSMUST00000075724.7 ENSMUST00000075724.8 NM_001025589 Q9Z205 RFXK_MOUSE Rfxb Tvl1 uc009lyu.1 uc009lyu.2 uc009lyu.3 Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (By similarity). May also potentiate the activation of RAF1 (PubMed:10329666). Forms homodimers (PubMed:10329666). The RFX heterotetrameric complex consists of 2 molecules of RFX5 and one each of RFXAP and RFX- B/RFXANK; with each subunit representing a separate complementation group. Interacts (via ankyrin repeats) with RFX5 (via PxLPxI/L motif); the interaction is direct. RFX forms cooperative DNA binding complexes with X2BP and CBF/NF-Y. RFX associates with CIITA to form an active transcriptional complex (By similarity). Interacts with RAF1 (PubMed:10329666). Interacts with RFX7 (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q9Z205-1; Sequence=Displayed; Name=Short; IsoId=Q9Z205-2; Sequence=VSP_000285; Expressed primarily in thymus, lung and testis. Interacts with RAF-1 via its C-terminal ankyrin repeat domain. The same domain also mediates its homodimerization (PubMed:10329666). The third ankyrin repeat is required for association with the two other RFX subunits; RFX5 and RFXAP. The three central ANK repeats mediate binding to the PxLPxI/L motif of RFX5 (By similarity). Phosphorylated by RAF1. DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol Ras protein signal transduction histone deacetylase binding intercellular bridge positive regulation of transcription from RNA polymerase II promoter uc009lyu.1 uc009lyu.2 uc009lyu.3 
ENSMUST00000075738.6 Cox6b1 ENSMUST00000075738.6 cytochrome c oxidase, subunit 6B1, transcript variant 1 (from RefSeq NM_025628.3) CX6B1_MOUSE Cox6b ENSMUST00000075738.1 ENSMUST00000075738.2 ENSMUST00000075738.3 ENSMUST00000075738.4 ENSMUST00000075738.5 NM_025628 P56391 Q545A3 uc009gfl.1 uc009gfl.2 uc009gfl.3 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Energy metabolism; oxidative phosphorylation. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side Belongs to the cytochrome c oxidase subunit 6B family. mitochondrion mitochondrial inner membrane mitochondrial intermembrane space respiratory chain complex IV uc009gfl.1 uc009gfl.2 uc009gfl.3 
ENSMUST00000075756.3 Or6d12 ENSMUST00000075756.3 olfactory receptor family 6 subfamily D member 12 (from RefSeq NM_001011800.2) ENSMUST00000075756.1 ENSMUST00000075756.2 NM_001011800 Olfr212 Or6d12 Q7TS33 Q7TS33_MOUSE uc009dkf.1 uc009dkf.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AK029829.1, BC141000.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009dkf.1 uc009dkf.2 
ENSMUST00000075759.13 Abl1 ENSMUST00000075759.13 c-abl oncogene 1, non-receptor tyrosine kinase, transcript variant 5 (from RefSeq NM_001283047.1) Abl1 ENSMUST00000075759.1 ENSMUST00000075759.10 ENSMUST00000075759.11 ENSMUST00000075759.12 ENSMUST00000075759.2 ENSMUST00000075759.3 ENSMUST00000075759.4 ENSMUST00000075759.5 ENSMUST00000075759.6 ENSMUST00000075759.7 ENSMUST00000075759.8 ENSMUST00000075759.9 NM_001283047 Q3SYK5 Q3SYK5_MOUSE uc008jeb.1 uc008jeb.2 uc008jeb.3 uc008jeb.4 uc008jeb.5 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Belongs to the protein kinase superfamily. Tyr protein kinase family. nucleotide binding magnesium ion binding four-way junction DNA binding bubble DNA binding phosphotyrosine binding positive regulation of protein phosphorylation protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein kinase C binding ATP binding nucleus nucleoplasm nucleolus cytoplasm cytosol protein phosphorylation cellular response to DNA damage stimulus DNA damage induced protein phosphorylation response to oxidative stress positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway protein C-terminus binding positive regulation of endothelial cell migration kinase activity phosphorylation nuclear body transferase activity SH3 domain binding peptidyl-tyrosine phosphorylation syntaxin binding manganese ion binding regulation of axon extension regulation of microtubule polymerization regulation of Cdc42 protein signal transduction regulation of actin cytoskeleton organization macromolecular complex platelet-derived growth factor receptor-beta signaling pathway peptidyl-tyrosine autophosphorylation neuropilin signaling pathway neuropilin binding SH2 domain binding signal transduction in response to DNA damage positive regulation of apoptotic process endothelial cell migration establishment of protein localization protein autophosphorylation perinuclear region of cytoplasm positive regulation of peptidyl-tyrosine phosphorylation mitogen-activated protein kinase binding positive regulation of oxidoreductase activity negative regulation of ubiquitin-protein transferase activity positive regulation of stress fiber assembly positive regulation of focal adhesion assembly proline-rich region binding cellular response to hydrogen peroxide DNA conformation change negative regulation of protein serine/threonine kinase activity positive regulation of substrate adhesion-dependent cell spreading negative regulation of phospholipase C activity positive regulation of microtubule binding positive regulation of actin filament binding activation of protein kinase C activity sequence-specific double-stranded DNA binding positive regulation of actin cytoskeleton reorganization regulation of response to DNA damage stimulus uc008jeb.1 uc008jeb.2 uc008jeb.3 uc008jeb.4 uc008jeb.5 
ENSMUST00000075764.8 Drd2 ENSMUST00000075764.8 dopamine receptor D2, transcript variant 1 (from RefSeq NM_010077.3) DRD2_MOUSE ENSMUST00000075764.1 ENSMUST00000075764.2 ENSMUST00000075764.3 ENSMUST00000075764.4 ENSMUST00000075764.5 ENSMUST00000075764.6 ENSMUST00000075764.7 NM_010077 P13953 P61168 Q0VGH9 uc009pja.1 uc009pja.2 uc009pja.3 Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (PubMed:30936473). Forms homo- and heterooligomers with DRD4 (By similarity). The interaction with DRD4 may modulate agonist-induced downstream signaling (By similarity). Interacts with CADPS and CADPS2 (By similarity). Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with ARRB2 (By similarity). Interacts with HTR2A (By similarity). Interacts with DRD1 (PubMed:25865831). [Isoform 1]: Interacts with KCNA2. [Isoform 2]: Interacts with KCNA2. Cell membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=P61168-1, P13953-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P61168-2, P13953-2; Sequence=VSP_010241; Expressed in retinal hyaloid vessels at postnatal day 6. [Isoform 1]: Expressed in the pituitary gland, stratum, brain stem and cortex. [Isoform 2]: Expressed in the brain stem. Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8. Conditional knockouts in vascular endothelial cells show an increase in activated Vegfr2/Kdr in the retinal hyaloid at P6, and hyaloid vessels continue to persist at P8. Belongs to the G-protein coupled receptor 1 family. dopamine neurotransmitter receptor activity, coupled via Gi/Go temperature homeostasis response to hypoxia acrosomal vesicle negative regulation of protein phosphorylation synaptic transmission, dopaminergic startle response response to amphetamine neurological system process involved in regulation of systemic arterial blood pressure regulation of heart rate regulation of sodium ion transport G-protein coupled receptor internalization positive regulation of neuroblast proliferation positive regulation of receptor internalization G-protein coupled receptor activity adrenergic receptor activity dopamine neurotransmitter receptor activity receptor binding protein binding plasma membrane integral component of plasma membrane cilium autophagy signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway dopamine receptor signaling pathway neuron-neuron synaptic transmission axonogenesis synapse assembly sensory perception of smell long-term memory grooming behavior locomotory behavior adult walking behavior feeding behavior protein localization drug binding negative regulation of cell proliferation associative learning visual learning response to light stimulus response to toxic substance response to iron ion regulation of dopamine secretion postsynaptic density response to inactivity membrane integral component of membrane Wnt signaling pathway lateral plasma membrane striatum development orbitofrontal cortex development cerebral cortex GABAergic interneuron migration adenohypophysis development endocytic vesicle negative regulation of cell migration axon dendrite peristalsis adult behavior synaptic vesicle membrane forebrain development auditory behavior cytoplasmic vesicle activation of protein kinase activity regulation of synaptic transmission, GABAergic positive regulation of cytokinesis circadian regulation of gene expression negative regulation of dopamine secretion response to histamine response to nicotine dopamine binding ionotropic glutamate receptor binding intracellular signal transduction positive regulation of urine volume positive regulation of renal sodium excretion sperm flagellum positive regulation of multicellular organism growth response to cocaine negative regulation of circadian sleep/wake cycle, sleep dopamine metabolic process response to drug drinking behavior identical protein binding protein homodimerization activity dendritic spine perikaryon regulation of potassium ion transport response to morphine regulation of MAPK cascade pigmentation regulation of phosphoprotein phosphatase activity axon terminus response to ethanol positive regulation of G-protein coupled receptor protein signaling pathway negative regulation of blood pressure negative regulation of innate immune response positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion acid secretion protein heterodimerization activity behavioral response to cocaine behavioral response to ethanol regulation of long-term neuronal synaptic plasticity response to axon injury branching morphogenesis of a nerve arachidonic acid secretion negative regulation of protein secretion positive regulation of neurogenesis modulation of synaptic transmission release of sequestered calcium ion into cytosol negative regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway regulation of neurotransmitter uptake regulation of dopamine uptake involved in synaptic transmission positive regulation of dopamine uptake involved in synaptic transmission regulation of synapse structural plasticity negative regulation of protein kinase B signaling negative regulation of synaptic transmission, glutamatergic positive regulation of growth hormone secretion prepulse inhibition phospholipase C-activating dopamine receptor signaling pathway negative regulation of dopamine receptor signaling pathway ciliary membrane negative regulation of cell death positive regulation of ERK1 and ERK2 cascade adenylate cyclase-activating adrenergic receptor signaling pathway regulation of locomotion involved in locomotory behavior non-motile cilium glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane positive regulation of glial cell-derived neurotrophic factor secretion positive regulation of long-term synaptic potentiation negative regulation of voltage-gated calcium channel activity regulation of synaptic vesicle exocytosis uc009pja.1 uc009pja.2 uc009pja.3 
ENSMUST00000075770.13 Megf10 ENSMUST00000075770.13 multiple EGF-like-domains 10 (from RefSeq NM_001001979.2) ENSMUST00000075770.1 ENSMUST00000075770.10 ENSMUST00000075770.11 ENSMUST00000075770.12 ENSMUST00000075770.2 ENSMUST00000075770.3 ENSMUST00000075770.4 ENSMUST00000075770.5 ENSMUST00000075770.6 ENSMUST00000075770.7 ENSMUST00000075770.8 ENSMUST00000075770.9 MEG10_MOUSE Megf10 NM_001001979 Q3TLU3 Q3UG73 Q6DIB5 uc008eyz.1 uc008eyz.2 uc008eyz.3 Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PubMed:27170117). Cooperates with ABCA1 within the process of engulfment (By similarity). Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PubMed:20828568). Necessary for astrocyte- dependent apoptotic neuron clearance in the developing cerebellum (PubMed:27170117). Plays a role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:28498977, Ref.10). May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PubMed:22407321). Homomer (Probable). Interacts with GULP1 and ABCA1. Interacts with AP2M1. Does not interact with MEGF11 (By similarity). Binds with high affinity to complement C1q (By similarity). Interacts (via the cytoplasmic domain) with NOTCH1 (via NICD domain) (PubMed:28498977). Cell membrane ingle-pass type I membrane protein Cell projection, phagocytic cup Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell surface that becomes firmely fixed to the substrate. Expressed at the cell surface in clusters around cell corpses during engulfment. During the engulfment of apoptotic thymocytes, recruited at the bottom of the forming phagocytic cup. Colocalizes with ABCA1 in absence of any phagocytic challenge. Does not localize within lamellipodia. Does not localize with MEGF11 (By similarity). Enriched at the sites of contact with apoptotic thymocyte cells. Expressed in cerebellum (at protein level). Expressed in kidney, stellate cells of the cerebellum and macrophage cell lines. Expressed in embryo at 15 dpc (at protein level). Expressed in embryo at 8, 10, 11, 13, 14 and 15 dpc. The EMI and EGF-like domains work in concert to promote self- assembly. Ubiquitinated; mono- and polyubiquitinated forms are detected. Phosphorylated on tyrosine residues. Phosphorylation at Tyr-1030 may be important for muscle cell proliferation. Mutants show at postnatal day 7 an increased amount of apoptotic cells in the developing cerebellum. However, adult brains do not show higher numbers of apoptotic cells in the cerebellum compared to wild-type. Astrocytes from knockout mice as well as heterozygous mice have a significant impairment in engulfment of apoptotic cells (PubMed:27170117). Reduced proliferation of primary myoblasts (Ref.10). Mutants have normal mobility and their skeletal muscles show mildly increased endomysial connective tissue. They display reduced motor activity after exercise and show slower muscle regeneration (PubMed:28498977). MEGF10 and DMD double knockout animals have pronounced fiber size variability and intracellular inclusions in the quadriceps femoris with extensive endomysial connective tissue infiltration. Mice develop muscle weakness, kyphosis and a waddling gait. At 2 months of age, they have reduced contractile force compared to wild-type mice. They display reduced motor activity after exercise and they walk shorter distances than wild-type. They have a delayed regeneration after muscle injury and an aberrant muscle fber typing and cross-sectional areas (PubMed:28498977). Belongs to the MEGF family. complement component C1q binding phagocytic cup scavenger receptor activity Notch binding plasma membrane phagocytosis cell adhesion muscle organ development skeletal muscle satellite cell activation skeletal muscle satellite cell differentiation skeletal muscle satellite cell proliferation membrane integral component of membrane muscle cell proliferation homotypic cell-cell adhesion cell projection apoptotic cell clearance engulfment of apoptotic cell recognition of apoptotic cell regulation of skeletal muscle tissue development regulation of muscle cell differentiation myoblast migration muscle cell development apoptotic process involved in development uc008eyz.1 uc008eyz.2 uc008eyz.3 
ENSMUST00000075774.5 Tubb2b ENSMUST00000075774.5 tubulin, beta 2B class IIB (from RefSeq NM_023716.2) ENSMUST00000075774.1 ENSMUST00000075774.2 ENSMUST00000075774.3 ENSMUST00000075774.4 NM_023716 Q3TG26 Q9CWF2 TBB2B_MOUSE uc007qbd.1 uc007qbd.2 uc007qbd.3 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Cytoplasm, cytoskeleton Strong expression is detected in the developing cortex and peripheral nervous system, as well as in the adult cerebellum, hippocampus and olfactory bulb. The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation. Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility (PubMed:33414192). Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:15890843). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (PubMed:23897886). Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle neuron migration GTPase activity structural constituent of cytoskeleton GTP binding cytoplasm cytoskeleton microtubule microtubule-based process nervous system development microtubule cytoskeleton protein heterodimerization activity modulation of synaptic transmission positive regulation of axon guidance embryonic brain development uc007qbd.1 uc007qbd.2 uc007qbd.3 
ENSMUST00000075775.6 Rex2 ENSMUST00000075775.6 reduced expression 2 (from RefSeq NM_001177767.1) A2AWF2 A2AWF2_MOUSE ENSMUST00000075775.1 ENSMUST00000075775.2 ENSMUST00000075775.3 ENSMUST00000075775.4 ENSMUST00000075775.5 NM_001177767 Rex2 uc008vsr.1 uc008vsr.2 uc008vsr.3 uc008vsr.4 uc008vsr.5 uc008vsr.6 nucleic acid binding nucleus regulation of transcription, DNA-templated metal ion binding uc008vsr.1 uc008vsr.2 uc008vsr.3 uc008vsr.4 uc008vsr.5 uc008vsr.6 
ENSMUST00000075792.5 Fthl17c ENSMUST00000075792.5 ferritin, heavy polypeptide-like 17, pseudogene 1 (from RefSeq NM_001277184.1) A2AHC6 A2AHC6_MOUSE ENSMUST00000075792.1 ENSMUST00000075792.2 ENSMUST00000075792.3 ENSMUST00000075792.4 Fthl17c Gm14511 Gm5634 NM_001277184 uc009spk.1 uc009spk.2 uc009spk.3 uc009spk.4 uc009spk.5 Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. ferroxidase activity iron ion binding cytoplasm iron ion transport cellular iron ion homeostasis intracellular sequestering of iron ion ferrous iron binding ferric iron binding identical protein binding metal ion binding oxidation-reduction process uc009spk.1 uc009spk.2 uc009spk.3 uc009spk.4 uc009spk.5 
ENSMUST00000075806.11 Atp13a5 ENSMUST00000075806.11 ATPase type 13A5, transcript variant 1 (from RefSeq NM_175650.4) AT135_MOUSE ENSMUST00000075806.1 ENSMUST00000075806.10 ENSMUST00000075806.2 ENSMUST00000075806.3 ENSMUST00000075806.4 ENSMUST00000075806.5 ENSMUST00000075806.6 ENSMUST00000075806.7 ENSMUST00000075806.8 ENSMUST00000075806.9 NM_175650 Q14BM0 Q3TYU2 Q8BUP1 uc007yvy.1 uc007yvy.2 uc007yvy.3 uc007yvy.4 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TYU2-1; Sequence=Displayed; Name=2; IsoId=Q3TYU2-2; Sequence=VSP_033924; Specifically expressed in brain and stomach. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. nucleotide binding ATP binding cell cation transport cellular calcium ion homeostasis membrane integral component of membrane hydrolase activity ATPase activity metal ion binding uc007yvy.1 uc007yvy.2 uc007yvy.3 uc007yvy.4 
ENSMUST00000075812.11 Nsd2 ENSMUST00000075812.11 Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19483677, PubMed:32862441, PubMed:31636135). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:19483677). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (By similarity). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (PubMed:19483677). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:19483677, PubMed:31636135, PubMed:32862441, PubMed:23241889). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (PubMed:19483677). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (PubMed:19483677). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (By similarity). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (PubMed:31636135). During B-cell development, required for the generation of the B1 lineage (PubMed:32862441). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (PubMed:32862441). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (PubMed:23241889). By regulating the methylation of histone H3 at 'Lys- 36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (PubMed:23241889). (from UniProt Q8BVE8) B3VCH6 BC079668 ENSMUST00000075812.1 ENSMUST00000075812.10 ENSMUST00000075812.2 ENSMUST00000075812.3 ENSMUST00000075812.4 ENSMUST00000075812.5 ENSMUST00000075812.6 ENSMUST00000075812.7 ENSMUST00000075812.8 ENSMUST00000075812.9 Kiaa1090 NSD2_MOUSE Q6ZPY1 Q7TSF5 Q811F0 Q8BVE8 Whsc1 uc290uow.1 uc290uow.2 Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19483677, PubMed:32862441, PubMed:31636135). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:19483677). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (By similarity). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (PubMed:19483677). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:19483677, PubMed:31636135, PubMed:32862441, PubMed:23241889). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (PubMed:19483677). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (PubMed:19483677). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (By similarity). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (PubMed:31636135). During B-cell development, required for the generation of the B1 lineage (PubMed:32862441). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (PubMed:32862441). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (PubMed:23241889). By regulating the methylation of histone H3 at 'Lys- 36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (PubMed:23241889). [Isoform RE-IIBP]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (By similarity). Mono-, di- and tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2, H3K27me3) (PubMed:18172012). Methylation of histone H3 at 'Lys-27' is controversial (By similarity). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:18172012). Reaction=L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60312, Rhea:RHEA-COMP:9785, Rhea:RHEA-COMP:9786, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence=; Reaction=L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60308, Rhea:RHEA-COMP:9785, Rhea:RHEA- COMP:9787, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61976; EC=2.1.1.357; Evidence= Interacts with HDAC1 (PubMed:19483677). Interacts (via PHD- type zinc fingers 1, 2 and 3) with SALL1 (PubMed:19483677). Interacts (via PHD-type 1, 2 and 3) with SALL4 (PubMed:19483677). Interacts with NANOG (PubMed:19483677). Interacts with OGT (PubMed:19483677). Interacts (via HMG box) with NKX2-5 (PubMed:19483677). Q8BVE8-2; P42582: Nkx2-5; NbExp=2; IntAct=EBI-11518042, EBI-297021; Q8BVE8-2; Q8BX22: Sall4; NbExp=3; IntAct=EBI-11518042, EBI-2312582; Nucleus romosome te=In embryonic stem (ES) cells, localizes to small foci, probably corresponding to euchromatin (PubMed:19483677). In B-cells, localizes to Ig heavy chain switch region during class switch recombination (PubMed:23241889). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BVE8-1; Sequence=Displayed; Name=2; IsoId=Q8BVE8-2; Sequence=VSP_021426; Name=3; IsoId=Q8BVE8-3; Sequence=VSP_021424, VSP_021425, VSP_021426; Name=RE-IIBP ; IsoId=Q8BVE8-4; Sequence=VSP_044420; During B-cell development, expressed in early B2 cell progenitors (pre- and pro-B cells) with a decrease in expression at later stages. Ubiquitously expressed in early development (PubMed:9618163). Highly expressed in neuroepithelium at 10.5 dpc, and in the forebrain, midbrain, frontal facial region, jaw, heart but not in the endocardial cushion, and cartilage primordial at 14.5 dpc (PubMed:19483677). Induced in CD4(+) T-cell in response to T-cell receptor (TCR) and CD28 stimulation (at protein level) (PubMed:31636135). Induced in B2-cells by IgM antibodies or lipopolysaccharide (LPS) stimulation (PubMed:32862441). Offspring number is low at birth (PubMed:19483677). After birth, pups have growth retardation and die within 10 days (PubMed:19483677). At 15.5 dpc, levels of trimethylated 'Lys-36' on histone H3 are reduced (PubMed:19483677). At 18.5 dpc, embryos are smaller with midline fusion defects due to a lack of ossification centers and some have cleft palates (PubMed:19483677). They also have heart defects including atrial and ventricular septal defects (PubMed:19483677). Conditional knockout in CD4(+) T-cells, reduces dimethylation of histone H3 at 'Lys-36' at the Bcl6 gene locus in response to T-cell activation which results in impaired Bcl6 expresseion (PubMed:31636135). Following immunization with ovalbumin antigen or sheep red blood cells, or infection with LCMV virus, follicular helper T (Tfh) cell differentiation and germinal center B cell response are reduced (PubMed:31636135). Also, following infection with LCMV virus, clearance of the virus is delayed (PubMed:31636135). No defect in T-cell development (PubMed:31636135). Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. Depending on the experimental set up and substrate used, NSD2 has been shown to mono-, di- or tri-methylate 'Lys-27', 'Lys-36' or 'Lys-79' of histone H3 and 'Lys-20' or 'Lys-44' of histone H4 (By similarity). However, dimethylation of nucleosomal histone H3 at 'Lys- 36' (H3K36me2) is likely to be the physiological reaction catalyzed by NSD2 (By similarity). Sequence=ACE75882.1; Type=Miscellaneous discrepancy; Note=Incorrectly indicated as originating from human.; Evidence=; Sequence=BAC37342.1; Type=Frameshift; Evidence=; Sequence=BAC98097.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter chromatin membranous septum morphogenesis atrial septum primum morphogenesis atrial septum secundum morphogenesis DNA binding chromatin binding protein binding nucleus chromosome chromatin organization regulation of transcription, DNA-templated methyltransferase activity histone H3-K36 methylation transferase activity histone-lysine N-methyltransferase activity methylation histone H4-K20 methylation sequence-specific DNA binding metal ion binding histone methyltransferase activity (H3-K36 specific) positive regulation of isotype switching to IgA isotypes bone development regulation of establishment of protein localization regulation of double-strand break repair via nonhomologous end joining uc290uow.1 uc290uow.2 
ENSMUST00000075821.10 Dnase1l1 ENSMUST00000075821.10 deoxyribonuclease 1-like 1, transcript variant 2 (from RefSeq NM_001172154.2) A0A6I8MWW4 A0A6I8MWW4_MOUSE Dnase1l1 ENSMUST00000075821.1 ENSMUST00000075821.2 ENSMUST00000075821.3 ENSMUST00000075821.4 ENSMUST00000075821.5 ENSMUST00000075821.6 ENSMUST00000075821.7 ENSMUST00000075821.8 ENSMUST00000075821.9 NM_001172154 uc012hkr.1 uc012hkr.2 uc012hkr.3 Belongs to the DNase I family. uc012hkr.1 uc012hkr.2 uc012hkr.3 
ENSMUST00000075827.5 Jag2 ENSMUST00000075827.5 jagged 2, transcript variant 1 (from RefSeq NM_010588.3) ENSMUST00000075827.1 ENSMUST00000075827.2 ENSMUST00000075827.3 ENSMUST00000075827.4 F8VPV5 JAG2_MOUSE NM_010588 O55139 O70219 Q9QYE5 uc007pfl.1 uc007pfl.2 uc007pfl.3 Putative Notch ligand involved in the mediation of Notch signaling. Plays an essential role during limb, craniofacial and thymic development. May be involved in myogenesis and in the development of peripheral and central nervous systems. Membrane; Single-pass type I membrane protein. Found to be highest in fetal thymus, epidermis, foregut dorsal root ganglia and inner ear. In 2-weeK-old mice, abundant in heart, lung, thymus, skeletal muscle, brain and testis. Expression overlaps partially with Notch1 expression. At 13 dpc, found in paravertebral vessels and dorsal root ganglia. At 14 dpc, in oropharyngeal epithelium, developing thymus and in the muscles of the tongue. By 15 dpc, in many tissues. skeletal system development in utero embryonic development cell fate determination respiratory system process Notch binding calcium ion binding protein binding plasma membrane integral component of plasma membrane cell communication Notch signaling pathway multicellular organism development spermatogenesis sensory perception of sound growth factor activity auditory receptor cell fate commitment membrane integral component of membrane morphogenesis of embryonic epithelium cell differentiation regulation of cell adhesion T cell differentiation regulation of cell proliferation odontogenesis of dentin-containing tooth gamma-delta T cell differentiation thymic T cell selection negative regulation of Notch signaling pathway positive regulation of Notch signaling pathway perinuclear region of cytoplasm epithelial cell apoptotic process involved in palatal shelf morphogenesis uc007pfl.1 uc007pfl.2 uc007pfl.3 
ENSMUST00000075837.8 Cyp3a41b ENSMUST00000075837.8 cytochrome P450, family 3, subfamily a, polypeptide 41B (from RefSeq NM_001105159.1) B2RQU5 CP341_MOUSE Cyp3a41 Cyp3a41a E9QJT9 ENSMUST00000075837.1 ENSMUST00000075837.2 ENSMUST00000075837.3 ENSMUST00000075837.4 ENSMUST00000075837.5 ENSMUST00000075837.6 ENSMUST00000075837.7 NM_001105159 Q9JMA7 uc057lom.1 uc057lom.2 Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Expressed in liver. Also expressed in the kidneys of female mice, with traces in the stomach, ovary, and heart of female mice and in the testis of male mice. Detected immediately after birth in the livers of animals of both sexes, but increases with age in females, whereas it is gradually reduced in males, resulting in predominantly female-specific expression in livers. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cellular_component endoplasmic reticulum endoplasmic reticulum membrane steroid metabolic process steroid hydroxylase activity retinoic acid 4-hydroxylase activity response to bacterium regulation of gene expression membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding organelle membrane demethylase activity intracellular membrane-bounded organelle metal ion binding testosterone 6-beta-hydroxylase activity oxidation-reduction process aromatase activity oxidative demethylation estrogen 16-alpha-hydroxylase activity uc057lom.1 uc057lom.2 
ENSMUST00000075838.8 A1cf ENSMUST00000075838.8 APOBEC1 complementation factor, transcript variant 1 (from RefSeq NM_001081074.2) A1CF_MOUSE Acf Asp E9QJS8 ENSMUST00000075838.1 ENSMUST00000075838.2 ENSMUST00000075838.3 ENSMUST00000075838.4 ENSMUST00000075838.5 ENSMUST00000075838.6 ENSMUST00000075838.7 NM_001081074 Q5FW55 Q5YD47 Q5YD48 uc008heu.1 uc008heu.2 uc008heu.3 uc008heu.4 Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay (By similarity). Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2 (By similarity). Interacts with RBM47 (PubMed:24916387). Nucleus Endoplasmic reticulum Cytoplasm Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum. Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1 (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q5YD48-1; Sequence=Displayed; Name=2 ; IsoId=Q5YD48-2; Sequence=VSP_051930; Name=3 ; IsoId=Q5YD48-3; Sequence=VSP_051931, VSP_051932; Expressed primarily in liver, small intestine and kidney. The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity (By similarity). Mice display embryonic lethality at E3.5 due to failure of embryos to implant. [Isoform 3]: Minor isoform detected in less than 10% of cDNA clones. nucleic acid binding RNA binding single-stranded RNA binding mRNA binding protein binding nucleus nucleoplasm nuclear heterochromatin cytoplasm endoplasmic reticulum mRNA processing embryo implantation mRNA localization resulting in posttranscriptional regulation of gene expression cytidine to uridine editing mRNA modification apolipoprotein B mRNA editing enzyme complex mRNA editing complex positive regulation of protein secretion protein stabilization double-stranded RNA binding uc008heu.1 uc008heu.2 uc008heu.3 uc008heu.4 
ENSMUST00000075843.13 Adgre5 ENSMUST00000075843.13 adhesion G protein-coupled receptor E5, transcript variant 1 (from RefSeq NM_011925.3) Adgre5 Cd97 E9QJS7 E9QJS7_MOUSE ENSMUST00000075843.1 ENSMUST00000075843.10 ENSMUST00000075843.11 ENSMUST00000075843.12 ENSMUST00000075843.2 ENSMUST00000075843.3 ENSMUST00000075843.4 ENSMUST00000075843.5 ENSMUST00000075843.6 ENSMUST00000075843.7 ENSMUST00000075843.8 ENSMUST00000075843.9 NM_011925 uc009mlc.1 uc009mlc.2 uc009mlc.3 uc009mlc.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. transmembrane signaling receptor activity G-protein coupled receptor activity calcium ion binding cell surface receptor signaling pathway G-protein coupled receptor signaling pathway membrane integral component of membrane uc009mlc.1 uc009mlc.2 uc009mlc.3 uc009mlc.4 
ENSMUST00000075844.4 Or2y6 ENSMUST00000075844.4 olfactory receptor family 2 subfamily Y member 6 (from RefSeq NM_207253.1) ENSMUST00000075844.1 ENSMUST00000075844.2 ENSMUST00000075844.3 NM_207253 Olfr1371 Or2y6 Q7TQT7 Q7TQT7_MOUSE uc007ive.1 uc007ive.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC106788.1, BC106789.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007ive.1 uc007ive.2 
ENSMUST00000075845.11 Arhgap35 ENSMUST00000075845.11 Rho GTPase activating protein 35 (from RefSeq NM_172739.4) Arhgap35 ENSMUST00000075845.1 ENSMUST00000075845.10 ENSMUST00000075845.2 ENSMUST00000075845.3 ENSMUST00000075845.4 ENSMUST00000075845.5 ENSMUST00000075845.6 ENSMUST00000075845.7 ENSMUST00000075845.8 ENSMUST00000075845.9 Grlf1 Kiaa1722 NM_172739 P190A Q3UGY1 Q69ZC4 Q91YM2 RHG35_MOUSE p190ARHOGAP uc009fhw.1 uc009fhw.2 uc009fhw.3 Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:16971514). This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (PubMed:11044403, PubMed:11283609, PubMed:18502760, PubMed:21945077). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (PubMed:16971514). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (PubMed:11283609). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (PubMed:11044403, PubMed:26859289, PubMed:18502760). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (PubMed:21945077). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'- GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (By similarity). Interacts with the general transcription factor GTF2I, the interaction sequesters GTF2I in the cytoplasm (By similarity). Interacts with RASA1 (PubMed:16971514). Cytoplasm, cytoskeleton, cilium basal body Cytoplasm Nucleus Cell membrane Note=In response to integrins and SDC4 and upon phosphorylation by PKC, relocalizes from the cytoplasm to regions of plasma membrane ruffling where it colocalizes with polymerized actin. Expressed in the developing kidneys (PubMed:26859289). Expressed in all regions of the mature nervous system (at protein level) (PubMed:11044403). Detected in neutrophils (at protein level) (PubMed:20675588). At 12.5 dpc, the highest level of expression is in the spinal cord and lower expression levels are seen in the developing brain. At 15.5 dpc, highly expressed in brain, spinal cord and eyes (PubMed:11044403). In developing kidney, at 17.5 dpc, low expression is observed in the glomerulus, while high expression levels are detected in the proximal tubule (PubMed:26859289). At 14.5 dpc, is expressed within the epithelial compartment of the embryonic mammary bud and at lower level in the surrounding stroma and skin. Also expressed at terminal end bunds (TEB) at comparable levels in body and cap cells as well as in fibroblasts and stroma surrounding the TEB (PubMed:21945077). N-terminal part (1-266) has GTPase activity. Required for proper cellular localization. Mutation of this region is a severely defective loss of function. Mutants have defective morphogenesis of neural retinal tissue, agenesis of the corpus callosum due to defectuous midline fusion of the cerebral hemispheres (PubMed:11044403). Mutants show defects in axon guidance and fasciculation (PubMed:11283609). The pG1 pseudoGTPase domain does not bind GTP. Phosphorylation of Tyr-1105 by PTK6 promotes the association with RASA1, inactivating RHOA while activating RAS. Phosphorylation at Tyr- 308 by PDGFRA inhibits binding to GTF2I (By similarity). Phosphorylated by PRKCA at Ser-1221 and Thr-1226, induces relocalization from the cytoplasm to regions of plasma membrane ruffling and prevents the binding and substrate specificity regulation by phospholipids (PubMed:11044403). In brain, phosphorylated by FYN and SRC (PubMed:11283609). During focal adhesion formation, phosphorylated by MAPK1 and MAPK3 at the C-terminal region, probably at Ser-1451, Ser- 1476, Thr-1480 and Ser-1483. Phosphorylation by MAPK1 and MAPK3 inhibits GAP function and localizes ARGHAP35 away from newly forming focal adhesions and stress fibers in cells spreading on fibronectin (By similarity). Phosphorylation at Ser-1476 and Thr-1480 by GSK3B requires priming by MAPK and inhibits RhoGAP activity and modulates polarized cell migration (PubMed:18502760). Deficiency leads to perinatal lethality and defective neural development. One third of the fetuses show exencephaly and spina bifida as well as defective kidney development. negative regulation of transcription from RNA polymerase II promoter nucleotide binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding neural tube closure DNA binding GTPase activity GTPase activator activity GTP binding phospholipid binding nucleus cytoplasm cytosol cytoskeleton plasma membrane signal transduction integrin-mediated signaling pathway axon guidance axonal fasciculation regulation of actin polymerization or depolymerization lipid binding regulation of cell shape positive regulation of neuron projection development actin cytoskeleton membrane cell migration central nervous system neuron axonogenesis mammary gland development forebrain development establishment or maintenance of actin cytoskeleton polarity cellular response to extracellular stimulus GTPase activating protein binding regulation of actin cytoskeleton organization negative regulation of Rho protein signal transduction ciliary basal body cell projection camera-type eye development negative regulation of vascular permeability positive regulation of GTPase activity wound healing, spreading of cells macromolecular complex binding positive regulation of cilium assembly negative regulation of transcription, DNA-templated regulation of axonogenesis neuron projection guidance uc009fhw.1 uc009fhw.2 uc009fhw.3 
ENSMUST00000075853.6 Cks2 ENSMUST00000075853.6 CDC28 protein kinase regulatory subunit 2 (from RefSeq NM_025415.3) Cks2 ENSMUST00000075853.1 ENSMUST00000075853.2 ENSMUST00000075853.3 ENSMUST00000075853.4 ENSMUST00000075853.5 NM_025415 Q545R9 Q545R9_MOUSE uc007qmh.1 uc007qmh.2 uc007qmh.3 uc007qmh.4 Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. Forms a homohexamer that can probably bind six kinase subunits. Belongs to the CKS family. regulation of cyclin-dependent protein serine/threonine kinase activity cell cycle kinase activity phosphorylation cyclin-dependent protein serine/threonine kinase regulator activity cell division uc007qmh.1 uc007qmh.2 uc007qmh.3 uc007qmh.4 
ENSMUST00000075858.4 Ugt2b37 ENSMUST00000075858.4 UDP glucuronosyltransferase 2 family, polypeptide B37 (from RefSeq NM_053215.3) ENSMUST00000075858.1 ENSMUST00000075858.2 ENSMUST00000075858.3 NM_053215 Q8VCN3 Q8VCN3_MOUSE Ugt2b37 uc008xyg.1 uc008xyg.2 uc008xyg.3 Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; Membrane ; Single- pass membrane protein Belongs to the UDP-glycosyltransferase family. nuclear outer membrane mitochondrial inner membrane endoplasmic reticulum UDP-glycosyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups intracellular membrane-bounded organelle uc008xyg.1 uc008xyg.2 uc008xyg.3 
ENSMUST00000075869.13 Fbxo40 ENSMUST00000075869.13 F-box protein 40, transcript variant 1 (from RefSeq NM_001358217.1) ENSMUST00000075869.1 ENSMUST00000075869.10 ENSMUST00000075869.11 ENSMUST00000075869.12 ENSMUST00000075869.2 ENSMUST00000075869.3 ENSMUST00000075869.4 ENSMUST00000075869.5 ENSMUST00000075869.6 ENSMUST00000075869.7 ENSMUST00000075869.8 ENSMUST00000075869.9 Fbxo40 NM_001358217 Q3KN92 Q3KN92_MOUSE uc007zdl.1 uc007zdl.2 uc007zdl.3 zinc ion binding protein ubiquitination metal ion binding ubiquitin protein ligase activity uc007zdl.1 uc007zdl.2 uc007zdl.3 
ENSMUST00000075872.4 Mysm1 ENSMUST00000075872.4 myb-like, SWIRM and MPN domains 1 (from RefSeq NM_177239.3) A2AJE3 B9EKJ6 ENSMUST00000075872.1 ENSMUST00000075872.2 ENSMUST00000075872.3 Kiaa1915 MYSM1_MOUSE NM_177239 Q3TPV7 Q69Z66 Q8BRP5 Q8C4N1 uc008tsn.1 uc008tsn.2 uc008tsn.3 Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:26474655, PubMed:27895164, PubMed:30405132). Participates in the normal programming of B-cell responses to antigen after the maturation process (PubMed:27895164). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:26474655, PubMed:30405132). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (PubMed:26474655). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (PubMed:30405132). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:22169041, PubMed:24062447, PubMed:25217698, PubMed:26348977). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (By similarity). Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones (By similarity). Nucleus toplasm te=Localizes to the cytoplasm in response to bacterial infection. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69Z66-1; Sequence=Displayed; Name=2; IsoId=Q69Z66-2; Sequence=VSP_018212; Contains an N-terminal SANT domain that mediates histone/DNA binding, a central SWIRM domain to mediate interaction with chromatin associated proteins, and a C-terminal MPN domain that contains the metalloprotease activity. Deficient mice elicit hyper-inflammatory responses, are more susceptible to septic shock, more resistant to RNA virus replication but exhibit early death upon DNA viral infection (PubMed:26474655, PubMed:33086059). They also show an impaired B-cell development (PubMed:22169041, PubMed:26348977, PubMed:27895164). In a similar way, NK-cell and dendritic cell development is impaired in deletion mutant (PubMed:25217698, PubMed:24062447). An enhanced systemic inflammation can be observed characterized by higher cytokine levels, as well as the hepatocellular enzyme alanine aminotransferase, a marker of liver damage (PubMed:30405132). Belongs to the peptidase M67A family. MYSM1 subfamily. DNA binding transcription coactivator activity thiol-dependent ubiquitin-specific protease activity nucleus nucleoplasm plasma membrane chromatin organization chromatin remodeling proteolysis peptidase activity metallopeptidase activity SWI/SNF complex hydrolase activity regulation of cell migration macromolecular complex monoubiquitinated histone H2A deubiquitination thiol-dependent ubiquitinyl hydrolase activity histone binding pigmentation positive regulation of transcription from RNA polymerase II promoter metal ion binding regulation of hair follicle development regulation of hemopoiesis uc008tsn.1 uc008tsn.2 uc008tsn.3 
ENSMUST00000075888.6 Zic2 ENSMUST00000075888.6 zinc finger protein of the cerebellum 2 (from RefSeq NM_009574.3) ENSMUST00000075888.1 ENSMUST00000075888.2 ENSMUST00000075888.3 ENSMUST00000075888.4 ENSMUST00000075888.5 F8VPV3 F8VPV3_MOUSE NM_009574 Zic2 uc007vbd.1 uc007vbd.2 uc007vbd.3 Belongs to the GLI C2H2-type zinc-finger protein family. nucleic acid binding nucleus nuclear body uc007vbd.1 uc007vbd.2 uc007vbd.3 
ENSMUST00000075895.9 Pex19 ENSMUST00000075895.9 peroxisomal biogenesis factor 19, transcript variant 1 (from RefSeq NM_023041.3) ENSMUST00000075895.1 ENSMUST00000075895.2 ENSMUST00000075895.3 ENSMUST00000075895.4 ENSMUST00000075895.5 ENSMUST00000075895.6 ENSMUST00000075895.7 ENSMUST00000075895.8 NM_023041 PEX19_MOUSE Pxf Q4FJU7 Q8CEE1 Q8VCI5 Q921H0 Q9CZC1 Q9QUQ1 uc007dpq.1 uc007dpq.2 uc007dpq.3 uc007dpq.4 Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF (By similarity). Q8VCI5; Q64364-1: Cdkn2a; NbExp=4; IntAct=EBI-1810767, EBI-1202306; Cytoplasm Peroxisome membrane ; Lipid-anchor ; Cytoplasmic side Note=Mainly cytoplasmic, some fraction membrane-associated to the outer surface of peroxisomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VCI5-1; Sequence=Displayed; Name=2; IsoId=Q8VCI5-2; Sequence=VSP_012652; Belongs to the peroxin-19 family. protein binding nucleus nucleoplasm cytoplasm peroxisome peroxisomal membrane cytosol protein targeting to peroxisome peroxisome organization membrane integral component of membrane peroxisome membrane biogenesis peroxisome fission brush border membrane macromolecular complex peroxisome membrane class-1 targeting sequence binding protein import into peroxisome membrane protein N-terminus binding protein stabilization ATPase binding chaperone-mediated protein folding chaperone-mediated protein transport establishment of protein localization to peroxisome negative regulation of lipid binding uc007dpq.1 uc007dpq.2 uc007dpq.3 uc007dpq.4 
ENSMUST00000075896.7 Tsnax ENSMUST00000075896.7 translin-associated factor X (from RefSeq NM_016909.3) ENSMUST00000075896.1 ENSMUST00000075896.2 ENSMUST00000075896.3 ENSMUST00000075896.4 ENSMUST00000075896.5 ENSMUST00000075896.6 NM_016909 Q3UJR2 Q9QZE7 TSNAX_MOUSE Trax uc009nya.1 uc009nya.2 Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity). Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner (By similarity). Q9QZE7; P30543: Adora2a; Xeno; NbExp=6; IntAct=EBI-2910751, EBI-2902822; Cytoplasm, perinuclear region Golgi apparatus Nucleus Note=Expressed in the cytoplasm in the presence of TSN (By similarity). Accumulate in the Golgi complex of mid-late pachytene spermatocytes. Detected in heart, brain, lung, liver, kidney and testis. Sumoylated with SUMO1. Belongs to the translin family. DNA binding single-stranded DNA binding endoribonuclease activity protein binding nucleus cytoplasm Golgi apparatus multicellular organism development spermatogenesis cell differentiation A2A adenosine receptor binding sequence-specific DNA binding macromolecular complex binding metal ion binding perinuclear region of cytoplasm RNA phosphodiester bond hydrolysis, endonucleolytic uc009nya.1 uc009nya.2 
ENSMUST00000075909.7 4933411G06Rik ENSMUST00000075909.7 4933411G06Rik (from geneSymbol) AK016770 ENSMUST00000075909.1 ENSMUST00000075909.2 ENSMUST00000075909.3 ENSMUST00000075909.4 ENSMUST00000075909.5 ENSMUST00000075909.6 uc287rdq.1 uc287rdq.2 uc287rdq.3 uc287rdq.1 uc287rdq.2 uc287rdq.3 
ENSMUST00000075934.7 Psg29 ENSMUST00000075934.7 pregnancy-specific beta-1-glycoprotein 29 (from RefSeq NM_054064.3) ENSMUST00000075934.1 ENSMUST00000075934.2 ENSMUST00000075934.3 ENSMUST00000075934.4 ENSMUST00000075934.5 ENSMUST00000075934.6 NM_054064 Psg29 Q3URN6 Q3URN6_MOUSE uc012fam.1 uc012fam.2 uc012fam.3 Belongs to the immunoglobulin superfamily. CEA family. molecular_function cellular_component female pregnancy biological_process uc012fam.1 uc012fam.2 uc012fam.3 
ENSMUST00000075941.12 Ppp2r3a ENSMUST00000075941.12 protein phosphatase 2, regulatory subunit B'', alpha, transcript variant 1 (from RefSeq NM_001161362.3) 3222402P14Rik B2RXC8 B2RXC8_MOUSE ENSMUST00000075941.1 ENSMUST00000075941.10 ENSMUST00000075941.11 ENSMUST00000075941.2 ENSMUST00000075941.3 ENSMUST00000075941.4 ENSMUST00000075941.5 ENSMUST00000075941.6 ENSMUST00000075941.7 ENSMUST00000075941.8 ENSMUST00000075941.9 NM_001161362 Ppp2r3a uc009rfh.1 uc009rfh.2 uc009rfh.3 uc009rfh.4 uc009rfh.5 protein phosphatase type 2A complex eye photoreceptor cell differentiation calcium ion binding protein dephosphorylation somatic muscle development protein phosphatase regulator activity protein binding, bridging regulation of phosphoprotein phosphatase activity positive regulation of protein catabolic process negative regulation of canonical Wnt signaling pathway regulation of cell motility involved in somitogenic axis elongation positive regulation of canonical Wnt signaling pathway uc009rfh.1 uc009rfh.2 uc009rfh.3 uc009rfh.4 uc009rfh.5 
ENSMUST00000075953.2 Tdpoz4 ENSMUST00000075953.2 TD and POZ domain containing 4 (from RefSeq NM_207272.2) E9QJY8 ENSMUST00000075953.1 NM_207272 Q14BT0 Q6YCH2 TDPZ4_MOUSE Tdpoz4 uc008qfn.1 uc008qfn.2 Strongly expressed in 2-cell embryos. No expression detected in other embryonic stages or in adult testis. Belongs to the Tdpoz family. nucleus cytoplasm ubiquitin-dependent protein catabolic process regulation of proteolysis ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process uc008qfn.1 uc008qfn.2 
ENSMUST00000075954.9 Taf1b ENSMUST00000075954.9 TATA-box binding protein associated factor, RNA polymerase I, B, transcript variant 1 (from RefSeq NM_020614.2) E9QJY7 ENSMUST00000075954.1 ENSMUST00000075954.2 ENSMUST00000075954.3 ENSMUST00000075954.4 ENSMUST00000075954.5 ENSMUST00000075954.6 ENSMUST00000075954.7 ENSMUST00000075954.8 NM_020614 P97358 Q08AT7 Q3V292 Q6NSS9 TAF1B_MOUSE uc007nek.1 uc007nek.2 uc007nek.3 uc007nek.4 Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1C. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with TBP and RRN3. Interacts with FLNA (via N-terminus). Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P97358-1; Sequence=Displayed; Name=2; IsoId=P97358-2; Sequence=VSP_028024, VSP_028025; Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N- terminal zinc finger, a connecting region (composed of B-reader and B- linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a step preceding synthesis of the first 40 nucleotides (By similarity). Belongs to the RRN7/TAF1B family. RNA polymerase I transcription factor complex RNA polymerase I CORE element sequence-specific DNA binding RNA polymerase I transcriptional preinitiation complex assembly DNA binding protein binding nucleus nucleoplasm RNA polymerase transcription factor SL1 complex nucleolus transcription from RNA polymerase I promoter transcription of nuclear large rRNA transcript from RNA polymerase I promoter metal ion binding RNA polymerase I core factor complex uc007nek.1 uc007nek.2 uc007nek.3 uc007nek.4 
ENSMUST00000075973.3 Mup4 ENSMUST00000075973.3 major urinary protein 4 (from RefSeq NM_008648.2) ENSMUST00000075973.1 ENSMUST00000075973.2 MUP4_MOUSE NM_008648 P11590 uc008tag.1 uc008tag.2 uc008tag.3 Binds pheromones, likely to displace pheromones complexed to urinary MUPs and transport them to the vomeronasal organ (VNO) where they associate with their neuronal receptor(s). MUP4 is highly specific for the male mouse pheromone 2-sec-butyl-4,5-dihydrothiazole (SBT). Secreted. Expressed in lacrimal gland, parotid gland, sublingual gland, nasal mucus, and vomeronasal organ. Belongs to the calycin superfamily. Lipocalin family. insulin-activated receptor activity protein binding pheromone binding extracellular region extracellular space nucleus cytosol energy reserve metabolic process insulin receptor signaling pathway aerobic respiration positive regulation of gene expression negative regulation of lipid storage positive regulation of glucose metabolic process heat generation small molecule binding glucose homeostasis locomotor rhythm negative regulation of gluconeogenesis positive regulation of lipid metabolic process negative regulation of transcription, DNA-templated negative regulation of lipid biosynthetic process positive regulation of protein kinase B signaling negative regulation of insulin secretion involved in cellular response to glucose stimulus mitochondrion morphogenesis cellular response to lipid uc008tag.1 uc008tag.2 uc008tag.3 
ENSMUST00000075980.12 Tmem107 ENSMUST00000075980.12 transmembrane protein 107, transcript variant 1 (from RefSeq NM_025838.2) B2RPS9 ENSMUST00000075980.1 ENSMUST00000075980.10 ENSMUST00000075980.11 ENSMUST00000075980.2 ENSMUST00000075980.3 ENSMUST00000075980.4 ENSMUST00000075980.5 ENSMUST00000075980.6 ENSMUST00000075980.7 ENSMUST00000075980.8 ENSMUST00000075980.9 NM_025838 Q5SUQ6 Q9CPV0 Q9CZ71 TM107_MOUSE Tmem107 uc007jpc.1 uc007jpc.2 uc007jpc.3 uc007jpc.4 Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types. During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (PubMed:26595381, PubMed:26518474). Part of the tectonic-like complex (also named B9 complex). Interacts with TMEM237, TMEM231, MKS1 and TMEM216. Membrane ; Multi-pass membrane protein Cell projection, cilium. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CPV0-1; Sequence=Displayed; Name=2; IsoId=Q9CPV0-2; Sequence=VSP_021214; Note=Defect in TMEM107 is the cause of the schlei phenotype. Schlei mice display Shh-related defects including, preaxial polydactyly, exencephaly, and disrupted ventral neural tube patterning. Mice shown decreased numbers of cilia in several developing tissues and organs. However, nodal cilia appear normal in schlei mutants and subsequently, no left-right defects are observed. molecular_function cilium multicellular organism development membrane integral component of membrane neural tube patterning cell projection organization ciliary transition zone MKS complex embryonic digit morphogenesis cell projection cilium assembly protein localization to ciliary transition zone non-motile cilium assembly uc007jpc.1 uc007jpc.2 uc007jpc.3 uc007jpc.4 
ENSMUST00000075983.6 Ldoc1 ENSMUST00000075983.6 regulator of NFKB signaling (from RefSeq NM_001018087.2) B1AV12 ENSMUST00000075983.1 ENSMUST00000075983.2 ENSMUST00000075983.3 ENSMUST00000075983.4 ENSMUST00000075983.5 Gm366 LDOC1_MOUSE NM_001018087 Q7TPY9 uc009tij.1 uc009tij.2 uc009tij.3 May have an important role in the development and/or progression of some cancers. Interacts with NOD2. Nucleus Belongs to the LDOC1 family. maternal placenta development molecular_function nucleus nucleolus maternal process involved in parturition cellular response to lipopolysaccharide cellular response to muramyl dipeptide regulation of growth hormone activity uc009tij.1 uc009tij.2 uc009tij.3 
ENSMUST00000075992.12 Pkib ENSMUST00000075992.12 protein kinase inhibitor beta, cAMP dependent, testis specific, transcript variant 3 (from RefSeq NM_001039051.2) ENSMUST00000075992.1 ENSMUST00000075992.10 ENSMUST00000075992.11 ENSMUST00000075992.2 ENSMUST00000075992.3 ENSMUST00000075992.4 ENSMUST00000075992.5 ENSMUST00000075992.6 ENSMUST00000075992.7 ENSMUST00000075992.8 ENSMUST00000075992.9 F8WGJ1 NM_001039051 Pkib Q3TZU5 Q3TZU5_MOUSE uc007fcq.1 uc007fcq.2 uc007fcq.3 uc007fcq.4 Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Belongs to the PKI family. protein kinase inhibitor activity cAMP-dependent protein kinase inhibitor activity negative regulation of protein kinase activity kinase activity phosphorylation negative regulation of protein serine/threonine kinase activity uc007fcq.1 uc007fcq.2 uc007fcq.3 uc007fcq.4 
ENSMUST00000075994.11 Pdzrn3 ENSMUST00000075994.11 PDZ domain containing RING finger 3 (from RefSeq NM_018884.2) ENSMUST00000075994.1 ENSMUST00000075994.10 ENSMUST00000075994.2 ENSMUST00000075994.3 ENSMUST00000075994.4 ENSMUST00000075994.5 ENSMUST00000075994.6 ENSMUST00000075994.7 ENSMUST00000075994.8 ENSMUST00000075994.9 Kiaa1095 NM_018884 PZRN3_MOUSE Q69ZS0 Q91Z03 Q9QY54 Q9QY55 Semcap3 uc009dcd.1 uc009dcd.2 uc009dcd.3 uc009dcd.4 E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with NLGN1 and EFNB2 (By similarity). Interacts with UBE2D2 and with MUSK via the first PDZ domain. In myotubes, the interaction between PDZRN3 and MUSK is enhanced upon agrin stimulation. Synapse Cytoplasm Note=Localizes to the postsynaptic region of neuromuscular junctions. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=SEMCAP-3A, PDZRN3B; IsoId=Q69ZS0-1; Sequence=Displayed; Name=2; Synonyms=SEMCAP-3B; IsoId=Q69ZS0-2; Sequence=VSP_012610; Name=3; Synonyms=PDZRN3A; IsoId=Q69ZS0-3; Sequence=VSP_039769; Highly expressed in skeletal and cardiac muscle and at lower levels in spinal cord and brain (at protein level). Also expressed in kidney and lung. In muscles, concentrated at the neuromuscular junction (NMJ). First detected at the NMJ at approximately 16.5 dpc, when NMJs have just formed. As the NMJ grows and matures, expression levels increase in concert with that of acetylcholine receptors. Levels stay relatively high until 14 days after birth, but decrease significantly by 21 days. Up-regulated during myogenic differentiation in C2C12 cells and during injury-induced muscle regeneration. The RING-type zinc finger domain is required for E3 ligase activity. Auto-ubiquitinated. Sequence=AAH10329.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; ubiquitin-protein transferase activity protein binding nucleus nucleoplasm cytoplasm cytosol neuromuscular junction development zinc ion binding protein ubiquitination transferase activity cell junction neuromuscular junction synapse metal ion binding ubiquitin protein ligase activity uc009dcd.1 uc009dcd.2 uc009dcd.3 uc009dcd.4 
ENSMUST00000075995.7 Cand2 ENSMUST00000075995.7 cullin associated and neddylation dissociated 2 (putative) (from RefSeq NM_025958.2) CAND2_MOUSE ENSMUST00000075995.1 ENSMUST00000075995.2 ENSMUST00000075995.3 ENSMUST00000075995.4 ENSMUST00000075995.5 ENSMUST00000075995.6 Kiaa0667 NM_025958 Q6PHT7 Q6ZQ73 Tip120b uc009djb.1 uc009djb.2 uc009djb.3 uc009djb.4 Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Binds TBP, CNOT3 and UBE3C. Q6ZQ73; O75175: CNOT3; Xeno; NbExp=3; IntAct=EBI-6504831, EBI-743073; Nucleus Highly expressed in embryonic limb buds. Ubiquitinated and targeted for proteasomal degradation. Belongs to the CAND family. Sequence=BAC97996.1; Type=Erroneous initiation; Evidence=; protein binding nucleus cytosol SCF complex assembly protein ubiquitination TBP-class protein binding uc009djb.1 uc009djb.2 uc009djb.3 uc009djb.4 
ENSMUST00000075999.5 Pramel18 ENSMUST00000075999.5 Belongs to the PRAME family. (from UniProt B1AUV4) B1AUV4 B1AUV4_MOUSE ENSMUST00000075999.1 ENSMUST00000075999.2 ENSMUST00000075999.3 ENSMUST00000075999.4 Gm12794 Pramel18 uc290ocs.1 uc290ocs.2 uc290ocs.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290ocs.1 uc290ocs.2 uc290ocs.3 
ENSMUST00000076034.8 B3gnt8 ENSMUST00000076034.8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8, transcript variant 1 (from RefSeq NM_146184.4) B3GN8_MOUSE B3galt7 B3gnt8 ENSMUST00000076034.1 ENSMUST00000076034.2 ENSMUST00000076034.3 ENSMUST00000076034.4 ENSMUST00000076034.5 ENSMUST00000076034.6 ENSMUST00000076034.7 NM_146184 Q8R3I9 uc009ftg.1 uc009ftg.2 uc009ftg.3 Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N- glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans (By similarity). Protein modification; protein glycosylation. Interacts with B3GNT2; this interaction greatly increases B3GNT2 catalytic activity, independently of B3GNT8 enzymatic activity. Golgi apparatus membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 31 family. Golgi membrane endoplasmic reticulum Golgi apparatus protein glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity membrane integral component of membrane protein N-acetylglucosaminyltransferase activity transferase activity transferase activity, transferring glycosyl groups poly-N-acetyllactosamine biosynthetic process uc009ftg.1 uc009ftg.2 uc009ftg.3 
ENSMUST00000076038.7 Cntnap5c ENSMUST00000076038.7 contactin associated protein-like 5C, transcript variant 1 (from RefSeq NM_001081653.3) CTP5C_MOUSE Caspr5-3 ENSMUST00000076038.1 ENSMUST00000076038.2 ENSMUST00000076038.3 ENSMUST00000076038.4 ENSMUST00000076038.5 ENSMUST00000076038.6 NM_001081653 Q0V8T7 uc008dew.1 uc008dew.2 uc008dew.3 May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication. Membrane ; Single-pass type I membrane protein Expressed in brain. Expressed from 6 dpc in brain. Belongs to the neurexin family. cell adhesion membrane integral component of membrane uc008dew.1 uc008dew.2 uc008dew.3 
ENSMUST00000076043.13 Sema6a ENSMUST00000076043.13 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A, transcript variant 2 (from RefSeq NM_001311097.1) ENSMUST00000076043.1 ENSMUST00000076043.10 ENSMUST00000076043.11 ENSMUST00000076043.12 ENSMUST00000076043.2 ENSMUST00000076043.3 ENSMUST00000076043.4 ENSMUST00000076043.5 ENSMUST00000076043.6 ENSMUST00000076043.7 ENSMUST00000076043.8 ENSMUST00000076043.9 NM_001311097 O35464 Q6P5A8 Q6PCN9 Q9EQ71 SEM6A_MOUSE Semaq uc008ewb.1 uc008ewb.2 uc008ewb.3 uc008ewb.4 Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. Active as a homodimer or oligomer. The SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a heterotetramer. Interacts with EVL. O35464; Q80UG2: Plxna4; NbExp=3; IntAct=EBI-8057848, EBI-8057809; O35464-1; P70207: Plxna2; NbExp=5; IntAct=EBI-15880936, EBI-771272; O35464-1; O35464-1: Sema6a; NbExp=9; IntAct=EBI-15880936, EBI-15880936; Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O35464-1; Sequence=Displayed; Name=2; IsoId=O35464-2; Sequence=VSP_012097; Name=3; IsoId=O35464-3; Sequence=VSP_012098; Particularly high levels in spinal cord, cerebellum, metencephalon, superior and inferior colliculus, diencephalon, olfactory bulb and eye. Temporally and spatially regulated during development. No visible phenotype. Mice are viable and fertile, and do not show any major behavioral defects. In developing cerebellum, migration of granule cells is impaired. Granule cells can form normal cell processes, but the movement of the nucleus seems to be impaired. Belongs to the semaphorin family. neural crest cell migration neuron migration transmembrane signaling receptor activity protein binding extracellular space plasma membrane integral component of plasma membrane apoptotic process cell surface receptor signaling pathway multicellular organism development nervous system development axon guidance membrane integral component of membrane negative regulation of angiogenesis cell differentiation semaphorin receptor binding positive regulation of cell migration axon cellular response to vascular endothelial growth factor stimulus identical protein binding chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis centrosome localization negative regulation of ERK1 and ERK2 cascade semaphorin-plexin signaling pathway negative regulation of vascular endothelial growth factor signaling pathway negative regulation of sprouting angiogenesis positive regulation of neuron migration uc008ewb.1 uc008ewb.2 uc008ewb.3 uc008ewb.4 
ENSMUST00000076046.7 Csf2ra ENSMUST00000076046.7 colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (from RefSeq NM_009970.2) CSF2R_MOUSE Csfgmra E9QJX0 ENSMUST00000076046.1 ENSMUST00000076046.2 ENSMUST00000076046.3 ENSMUST00000076046.4 ENSMUST00000076046.5 ENSMUST00000076046.6 NM_009970 Q00941 uc008icj.1 uc008icj.2 uc008icj.3 Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity). Membrane ; Single-pass type I membrane protein The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Belongs to the type I cytokine receptor family. Type 5 subfamily. cytokine receptor activity granulocyte colony-stimulating factor receptor activity plasma membrane external side of plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway cytokine binding granulocyte colony-stimulating factor signaling pathway receptor complex granulocyte colony-stimulating factor binding cellular response to granulocyte macrophage colony-stimulating factor stimulus uc008icj.1 uc008icj.2 uc008icj.3 
ENSMUST00000076048.5 Bglap ENSMUST00000076048.5 bone gamma carboxyglutamate protein (from RefSeq NM_007541.3) Bglap ENSMUST00000076048.1 ENSMUST00000076048.2 ENSMUST00000076048.3 ENSMUST00000076048.4 NM_007541 OSTCN_MOUSE Ocn P04641 P86546 uc008puy.1 uc008puy.2 uc008puy.3 uc008puy.4 This gene encodes one of the most abundant non-collagenous proteins in bone tissue that is localized to the mineralized matrix of bone. The encoded preproprotein undergoes proteolytic processing and post-translational gamma carboxylation to generate a mature, calcium-binding protein. Mice lacking the encoded protein develop abnormalities of bone remodelling. This gene is located adjacent to two other osteocalcin-related genes on chromosome 3. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX523252.1, CJ326308.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (PubMed:8684484). The carboxylated form binds strongly to apatite and calcium (PubMed:17693256). The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development (PubMed:17693256, PubMed:20655470, PubMed:20655471, PubMed:21333348, PubMed:24074871). Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure (PubMed:17693256, PubMed:20655470, PubMed:20655471). Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein- coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (PubMed:21333348). Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA) (PubMed:24074871, PubMed:28851741). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development (PubMed:24074871). Secreted Bone. Expressed in early bell stage dental mesenchymal cells at 15.5 dpc (at protein level) (PubMed:24028588). Expressed in bell stage dental mesenchymal cells at 17.5 dpc (PubMed:29148101). Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation by GGCX (By similarity). These residues are essential for the binding of calcium (By similarity). Carboxylated in a Ptprv/Esp- dependent process (PubMed:17693256, PubMed:20655470, PubMed:20655471). Decarboxylation promotes the hormone activity (PubMed:17693256, PubMed:20655470, PubMed:20655471, PubMed:21333348, PubMed:24074871). Mice lacking Bglap and Bglap2 show increased bone formation, characterized by higher bone mass and bones of improved functional quality (PubMed:8684484). Mice lacking Bglap and Bglap2 also display reduced male fertility due to decreased testosterone production in the testes (PubMed:21333348). Mice lacking Bglap and Bglap2 are passive and show greater anxiety-like behaviors due to impaired synthesis of neurotransmitters (PubMed:24074871). Belongs to the osteocalcin/matrix Gla protein family. ossification osteoblast differentiation calcium ion binding extracellular region extracellular space cytoplasm rough endoplasmic reticulum Golgi apparatus structural constituent of bone dendrite regulation of bone mineralization biomineral tissue development vesicle response to vitamin K cell projection perikaryon hydroxyapatite binding metal ion binding bone development cellular response to BMP stimulus regulation of cellular response to insulin stimulus uc008puy.1 uc008puy.2 uc008puy.3 uc008puy.4 
ENSMUST00000076052.8 Prcp ENSMUST00000076052.8 prolylcarboxypeptidase (angiotensinase C) (from RefSeq NM_028243.3) ENSMUST00000076052.1 ENSMUST00000076052.2 ENSMUST00000076052.3 ENSMUST00000076052.4 ENSMUST00000076052.5 ENSMUST00000076052.6 ENSMUST00000076052.7 NM_028243 PCP_MOUSE Q3TLW3 Q3V302 Q7TMR0 Q8BKK3 Q8R0T8 Q9D049 uc009iik.1 uc009iik.2 uc009iik.3 uc009iik.4 Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity). Reaction=Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid.; EC=3.4.16.2; Homodimer. Lysosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TMR0-1; Sequence=Displayed; Name=2; IsoId=Q7TMR0-2; Sequence=VSP_039456; Belongs to the peptidase S28 family. regulation of thyroid hormone mediated signaling pathway plasma kallikrein-kinin cascade negative regulation of systemic arterial blood pressure carboxypeptidase activity lysosome proteolysis peptidase activity serine-type peptidase activity dipeptidyl-peptidase activity hydrolase activity glucose homeostasis regulation of blood vessel endothelial cell migration basal part of cell angiogenesis involved in wound healing energy homeostasis regulation of reactive oxygen species metabolic process uc009iik.1 uc009iik.2 uc009iik.3 uc009iik.4 
ENSMUST00000076061.4 Prp2 ENSMUST00000076061.4 proline rich protein 2 (from RefSeq NM_031499.3) ENSMUST00000076061.1 ENSMUST00000076061.2 ENSMUST00000076061.3 F8VPU9 F8VPU9_MOUSE NM_031499 Prp2 uc291jos.1 uc291jos.2 This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an important dental function by protecting mice against toxic dietary polyphenols such as tannins and influence the visco-elastic properties of the mucus. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 6. [provided by RefSeq, Nov 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## uc291jos.1 uc291jos.2 
ENSMUST00000076070.9 Zcrb1 ENSMUST00000076070.9 zinc finger CCHC-type and RNA binding motif 1, transcript variant 1 (from RefSeq NM_026025.3) ENSMUST00000076070.1 ENSMUST00000076070.2 ENSMUST00000076070.3 ENSMUST00000076070.4 ENSMUST00000076070.5 ENSMUST00000076070.6 ENSMUST00000076070.7 ENSMUST00000076070.8 NM_026025 Q3TDL3 Q9CZ96 ZCRB1_MOUSE uc007xiu.1 uc007xiu.2 uc007xiu.3 Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Interacts with ZRSR1 (PubMed:29617656). Nucleus, nucleoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZ96-1; Sequence=Displayed; Name=2; IsoId=Q9CZ96-2; Sequence=VSP_020918; Expressed at higher level in heart and testis, and at lower level in cerebellum. Weakly expressed at low level in liver. mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus nucleoplasm spliceosomal complex U12-type spliceosomal complex mRNA processing zinc ion binding RNA splicing metal ion binding uc007xiu.1 uc007xiu.2 uc007xiu.3 
ENSMUST00000076071.3 Gm10115 ENSMUST00000076071.3 Gm10115 (from geneSymbol) AK081831 ENSMUST00000076071.1 ENSMUST00000076071.2 uc289svs.1 uc289svs.2 uc289svs.1 uc289svs.2 
ENSMUST00000076084.6 Ppp1r14d ENSMUST00000076084.6 protein phosphatase 1, regulatory inhibitor subunit 14D, transcript variant 2 (from RefSeq NM_028104.4) A2AV57 ENSMUST00000076084.1 ENSMUST00000076084.2 ENSMUST00000076084.3 ENSMUST00000076084.4 ENSMUST00000076084.5 Gbpi NM_028104 PP14D_MOUSE Q7TT52 Q9D878 uc008ltj.1 uc008ltj.2 uc008ltj.3 uc008ltj.4 uc008ltj.5 Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=GBPI-1; IsoId=Q7TT52-1; Sequence=Displayed; Name=2; Synonyms=GBPI-2; IsoId=Q7TT52-2; Sequence=VSP_011842; Isoform 1 is detected in intestine, kidney, lung, spleen, stomach and brain. Isoform 2 is detected in testis. Phosphorylated on several residues. Belongs to the PP1 inhibitor family. protein phosphatase inhibitor activity protein serine/threonine phosphatase inhibitor activity cellular_component cytoplasm regulation of phosphorylation negative regulation of protein serine/threonine phosphatase activity positive regulation of protein serine/threonine phosphatase activity uc008ltj.1 uc008ltj.2 uc008ltj.3 uc008ltj.4 uc008ltj.5 
ENSMUST00000076086.3 Vmn1r53 ENSMUST00000076086.3 vomeronasal 1 receptor 53 (from RefSeq NM_053226.2) A2RS76 A2RS76_MOUSE ENSMUST00000076086.1 ENSMUST00000076086.2 NM_053226 V1rb3 Vmn1r53 uc009cwy.1 uc009cwy.2 uc009cwy.3 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009cwy.1 uc009cwy.2 uc009cwy.3 
ENSMUST00000076091.4 Ctf2 ENSMUST00000076091.4 cardiotrophin 2 (from RefSeq NM_198858.1) Ctf2 ENSMUST00000076091.1 ENSMUST00000076091.2 ENSMUST00000076091.3 NM_198858 Q0VB69 Q0VB69_MOUSE uc009jwn.1 uc009jwn.2 uc009jwn.3 Secreted uc009jwn.1 uc009jwn.2 uc009jwn.3 
ENSMUST00000076099.4 Speer4f1 ENSMUST00000076099.4 spermatogenesis associated glutamate (E)-rich protein 4F1 (from RefSeq NM_027609.2) ENSMUST00000076099.1 ENSMUST00000076099.2 ENSMUST00000076099.3 NM_027609 Q9D5Q6 Q9D5Q6_MOUSE Speer4f Speer4f1 uc008wnk.1 uc008wnk.2 uc008wnk.3 molecular_function cellular_component biological_process uc008wnk.1 uc008wnk.2 uc008wnk.3 
ENSMUST00000076106.4 Rnase11 ENSMUST00000076106.4 ribonuclease, RNase A family, 11 (non-active) (from RefSeq NM_001011877.2) ENSMUST00000076106.1 ENSMUST00000076106.2 ENSMUST00000076106.3 NM_001011877 Raj1 Rnase11 W0UVF9 W0UVF9_MOUSE uc007tmi.1 uc007tmi.2 uc007tmi.3 Belongs to the pancreatic ribonuclease family. nucleic acid binding uc007tmi.1 uc007tmi.2 uc007tmi.3 
ENSMUST00000076110.11 Rnf2 ENSMUST00000076110.11 ring finger protein 2, transcript variant 4 (from RefSeq NM_011277.4) DinG ENSMUST00000076110.1 ENSMUST00000076110.10 ENSMUST00000076110.2 ENSMUST00000076110.3 ENSMUST00000076110.4 ENSMUST00000076110.5 ENSMUST00000076110.6 ENSMUST00000076110.7 ENSMUST00000076110.8 ENSMUST00000076110.9 NM_011277 O35699 O35729 Q4FJV5 Q8C1X8 Q9CQJ4 RING2_MOUSE Ring1b uc007cyx.1 uc007cyx.2 uc007cyx.3 E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15525528, PubMed:22325148, PubMed:28596365). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals (PubMed:15525528, PubMed:28596365). May be involved in the initiation of both imprinted and random X inactivation (PubMed:15525528). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:22325148, PubMed:16710298). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:15525528, PubMed:22325148, PubMed:16710298). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:16710298). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (PubMed:15525528, PubMed:16710298). Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers (PubMed:22226355). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation (PubMed:24980959). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence= Protein modification; protein ubiquitination. Component of chromatin-associated Polycomb (PcG) complexes (PubMed:22325148). Component of a number of PRC1-like complexes; these complexes contain either the polycomb group ring finger protein PCGF1, or PCGF2, or PCGF3, or BMI1, or PCGF5, or PCGF6 (PubMed:28596365, PubMed:16710298). Distinct PRC1-like complexes are composed of a RING1 subunit (RING1B or RING1A), one of the six PCGF proteins (PCGF1, PCGF2, PCGF3, BMI1, PCGF5 or PCGF6), one PHC protein (PHC1, PHC2 or PHC3) and one of the CBX proteins (CBX2, CBX4, CBX6, CBX7 or CBX8) (Probable). Part of a complex that contains RNF2, UB2D3 and BMI1; within that complex RNF2 and BMI1 form a tight heterodimer, where UB2D3 interacts only with RNF2. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (By similarity). Part of a complex that contains PCGF5, RNF2 and UBE2D3. Part of a complex that contains AUTS2, PCGF5, RNF2, CSNK2B and RYBP (By similarity). Interacts with CBX6 and CBX8 (By similarity). Interacts with PHC1, PCGF2, RYBP, CBX7, CBX4, CBX2, RNF1/RING1, BMI1 and PHC2 (PubMed:12183370, PubMed:16024804, PubMed:16710298, PubMed:19170609, PubMed:9312051, PubMed:10369680, PubMed:22325148, PubMed:22226355). Interaction with RYBP and CBX7 is mutually exclusive; both compete for the same binding site on RNF2 (PubMed:22325148). Component of repressive BCOR complex containing a Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RING1 (By similarity). Interacts with CBX2 and PHC1 (PubMed:22226355). Interacts with CHTOP (PubMed:22872859). Interacts with AURKB (PubMed:24034696). Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RNF1/RING1, RNF2/RING2, MBLR, L3MBTL2 and YAF2 (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with RYBP, HIP2 and TFCP2 (By similarity). Interacts with NUPR1 (By similarity). Q9CQJ4; A0A087WPF7: Auts2; NbExp=2; IntAct=EBI-927321, EBI-27122375; Q9CQJ4; P25916: Bmi1; NbExp=17; IntAct=EBI-927321, EBI-927401; Q9CQJ4; Q9QXV1: Cbx8; NbExp=5; IntAct=EBI-927321, EBI-1216641; Q9CQJ4; Q61177: Csnk2a1; NbExp=4; IntAct=EBI-927321, EBI-1216438; Q9CQJ4; Q6ZQ88: Kdm1a; NbExp=3; IntAct=EBI-927321, EBI-1216284; Q9CQJ4; Q6P1G2: Kdm2b; NbExp=4; IntAct=EBI-927321, EBI-1216214; Q9CQJ4; P23798: Pcgf2; NbExp=15; IntAct=EBI-927321, EBI-926857; Q9CQJ4; Q64028: Phc1; NbExp=7; IntAct=EBI-927321, EBI-927346; Q9CQJ4; Q9QWH1: Phc2; NbExp=7; IntAct=EBI-927321, EBI-642357; Q9CQJ4; O35730: Ring1; NbExp=3; IntAct=EBI-927321, EBI-929310; Q9CQJ4; Q8CCI5: Rybp; NbExp=8; IntAct=EBI-927321, EBI-929290; Q9CQJ4; Q9WTX5: Skp1; NbExp=4; IntAct=EBI-927321, EBI-1202363; Nucleus toplasm Chromosome te=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells (PubMed:12183370). The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells (PubMed:12183370). Expressed in embryonic stem cells. Monoubiquitinated, by auto-ubiquitination (PubMed:16710298). Polyubiquitinated in the presence of UBE2D3 (in vitro) (By similarity). negative regulation of transcription from RNA polymerase II promoter ubiquitin ligase complex mitotic cell cycle euchromatin heterochromatin gastrulation with mouth forming second sex chromatin chromatin binding ubiquitin-protein transferase activity protein binding nucleus nucleoplasm chromosome germ cell development zinc ion binding anterior/posterior axis specification protein ubiquitination histone ubiquitination nuclear body transferase activity PcG protein complex PRC1 complex histone H2A monoubiquitination histone H2A-K119 monoubiquitination negative regulation of sequence-specific DNA binding transcription factor activity metal ion binding ubiquitin protein ligase activity MLL1 complex RING-like zinc finger domain binding uc007cyx.1 uc007cyx.2 uc007cyx.3 
ENSMUST00000076119.6 Tas2r125 ENSMUST00000076119.6 taste receptor, type 2, member 125 (from RefSeq NM_207027.1) ENSMUST00000076119.1 ENSMUST00000076119.2 ENSMUST00000076119.3 ENSMUST00000076119.4 ENSMUST00000076119.5 NM_207027 Q7M710 T2r59 TR125_MOUSE Tas2r125 uc009eju.1 uc009eju.2 uc009eju.3 Putative taste receptor which may play a role in the perception of bitterness. Membrane ; Multi-pass membrane protein Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009eju.1 uc009eju.2 uc009eju.3 
ENSMUST00000076123.12 Zfp58 ENSMUST00000076123.12 zinc finger protein 58 (from RefSeq NM_001007575.2) ENSMUST00000076123.1 ENSMUST00000076123.10 ENSMUST00000076123.11 ENSMUST00000076123.2 ENSMUST00000076123.3 ENSMUST00000076123.4 ENSMUST00000076123.5 ENSMUST00000076123.6 ENSMUST00000076123.7 ENSMUST00000076123.8 ENSMUST00000076123.9 Mfg-1 NM_001007575 P16372 Q3TS54 Q6P8L3 Q7M6X1 Q8BRV1 Rslcan5 ZFP58_MOUSE Zfp817 uc007ray.1 uc007ray.2 uc007ray.3 uc007ray.4 May have a role during differentiation processes. Nucleus Expressed in liver, testis and, at considerably lower levels, in brain, spleen and heart. Expression increases upon differentiation and is not related to the cell cycle. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAH61200.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc007ray.1 uc007ray.2 uc007ray.3 uc007ray.4 
ENSMUST00000076124.7 Srrm4 ENSMUST00000076124.7 serine/arginine repetitive matrix 4, transcript variant 1 (from RefSeq NM_026886.4) ENSMUST00000076124.1 ENSMUST00000076124.2 ENSMUST00000076124.3 ENSMUST00000076124.4 ENSMUST00000076124.5 ENSMUST00000076124.6 NM_026886 Q8BKA3 Q8R1S5 Q9CW37 SRRM4_MOUSE uc008zfc.1 uc008zfc.2 uc008zfc.3 uc008zfc.4 Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural- specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural- specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (PubMed:19737518). Promotes alternative splicing of REST transcripts to produce REST isoform 2 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells (PubMed:21884984). Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (PubMed:25838543). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BKA3-1; Sequence=Displayed; Name=2; IsoId=Q8BKA3-2; Sequence=VSP_029639; Specifically expressed in neuronal cells (at protein level). Expressed in adult nervous system and sensory organ tissues. Expressed in both the central and peripheral nervous system in developing mice. Phosphorylated. About 85% of the mutant mice die in the first few hours after birth and few surviving animals display balance defects and exhibit persistent tremors. Mice show impaired development of the central and peripheral nervous systems in part by disrupting neurite outgrowth, cortical layering in the forebrain, and axon guidance in the corpus callosum. Belongs to the nSR100 family. regulation of alternative mRNA splicing, via spliceosome RNA binding mRNA binding nucleus mRNA processing nervous system development sensory perception of sound RNA splicing cell differentiation neuron maturation regulation of RNA splicing uc008zfc.1 uc008zfc.2 uc008zfc.3 uc008zfc.4 
ENSMUST00000076147.6 Ackr4 ENSMUST00000076147.6 atypical chemokine receptor 4 (from RefSeq NM_145700.2) ACKR4_MOUSE Ccr11 Ccrl1 ENSMUST00000076147.1 ENSMUST00000076147.2 ENSMUST00000076147.3 ENSMUST00000076147.4 ENSMUST00000076147.5 NM_145700 Q8C0M1 Q8QZW9 Q924I3 uc009rhi.1 uc009rhi.2 uc009rhi.3 uc009rhi.4 Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus and inhibits spontaneous autoimmunity. Forms heteromers with CXCR3. Interacts with ARRB1 and ARRB2 (By similarity). Early endosome Recycling endosome Cell membrane ; Multi-pass membrane protein Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity). Expressed in lung, heart, spleen, skeletal muscle, testis, astrocytes and microglia. Expressed by cortical thymic epithelial cells. The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated. Mice have a larger thymus with relatively fewer cortical thymic epithelial cells and this is associated with severe reductions in cortical CCL25 distribution and accumulation of DN2 thymocyte precursor cells in the medulla. The downstream effects materialize in reduced proportions of DN3 cells and significantly reduced numbers of cortical DN3 cells. Aberrant thymocyte development culminates in increased prevalence of spontaneous autoimmune-like disease, characterized by lymphocytic infiltration of peripheral organs. Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily. G-protein coupled receptor activity chemokine receptor activity scavenger receptor activity endosome early endosome plasma membrane endocytosis chemotaxis immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration external side of plasma membrane membrane integral component of membrane C-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding recycling endosome cell chemotaxis chemokine-mediated signaling pathway uc009rhi.1 uc009rhi.2 uc009rhi.3 uc009rhi.4 
ENSMUST00000076150.3 Tas2r124 ENSMUST00000076150.3 taste receptor, type 2, member 124 (from RefSeq NM_207026.1) ENSMUST00000076150.1 ENSMUST00000076150.2 NM_207026 Q7M718 T2r50 TR124_MOUSE Tas2r124 uc009ejm.1 uc009ejm.2 Putative taste receptor which may play a role in the perception of bitterness. Membrane ; Multi-pass membrane protein Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009ejm.1 uc009ejm.2 
ENSMUST00000076155.6 Eno1b ENSMUST00000076155.6 enolase 1B, retrotransposed (from RefSeq NM_001025388.2) EG433182 ENSMUST00000076155.1 ENSMUST00000076155.2 ENSMUST00000076155.3 ENSMUST00000076155.4 ENSMUST00000076155.5 Eno1 NM_001025388 Q5FW97 Q5FW97_MOUSE Q5XJG8 Q5XKE1 uc008ewh.1 uc008ewh.2 uc008ewh.3 uc008ewh.4 uc008ewh.5 This gene may represent an evolving pseudogene of the alpha-enolase (enolase 1, alpha non-neuron) gene, which has multiple pseudogenes. This gene has an intact open reading frame as well as strong transcriptional support. The length of encoded protein is conserved, compared to the original enolase 1 protein. The exact function of this gene is unknown. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC089539.1, SRR5189685.109089.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 4/5. Belongs to the enolase family. phosphopyruvate hydratase complex magnesium ion binding phosphopyruvate hydratase activity glycolytic process uc008ewh.1 uc008ewh.2 uc008ewh.3 uc008ewh.4 uc008ewh.5 
ENSMUST00000076169.4 Mtx3 ENSMUST00000076169.4 metaxin 3, transcript variant 3 (from RefSeq NR_160869.1) D3YTP3 D3YTP3_MOUSE ENSMUST00000076169.1 ENSMUST00000076169.2 ENSMUST00000076169.3 Mtx3 NR_160869 uc011zct.1 uc011zct.2 Membrane Mitochondrion outer membrane Belongs to the metaxin family. mitochondrial sorting and assembly machinery complex molecular_function cellular_component biological_process uc011zct.1 uc011zct.2 
ENSMUST00000076183.12 Rnf207 ENSMUST00000076183.12 ring finger protein 207 (from RefSeq NM_001033489.2) A6PW94 ENSMUST00000076183.1 ENSMUST00000076183.10 ENSMUST00000076183.11 ENSMUST00000076183.2 ENSMUST00000076183.3 ENSMUST00000076183.4 ENSMUST00000076183.5 ENSMUST00000076183.6 ENSMUST00000076183.7 ENSMUST00000076183.8 ENSMUST00000076183.9 Gm143 NM_001033489 Q3V3A7 RN207_MOUSE uc008waf.1 uc008waf.2 uc008waf.3 uc008waf.4 Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. Interacts with the core-glycosylated, but not the fully glycosylated form of KCNH2/HERG. Interacts with DNAJA1 and HSPA8. Interacts (via the C-terminus) with HSPA1A; this interaction additively increases KCNH2 expression. Cytoplasm Note=Probably located in the endoplasmic reticulum and/or possibly the cis-Golgi apparatus. Sequence=BAE20631.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; cytoplasm zinc ion binding positive regulation of gene expression Hsp70 protein binding ion channel binding metal ion binding perinuclear region of cytoplasm chaperone binding positive regulation of delayed rectifier potassium channel activity positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization uc008waf.1 uc008waf.2 uc008waf.3 uc008waf.4 
ENSMUST00000076186.4 Krtap19-2 ENSMUST00000076186.4 keratin associated protein 19-2 (from RefSeq NM_130870.1) ENSMUST00000076186.1 ENSMUST00000076186.2 ENSMUST00000076186.3 KR192_MOUSE Krtap16-1 Krtap16.1 NM_130870 Q3UUY7 Q925I0 uc007zvi.1 uc007zvi.2 uc007zvi.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Strong expression in narrowly defined pattern restricted to the lower and middle cortical regions of the hair shaft in both developing and cycling hair. During hair follicle regression (catagen), expression levels decrease until expression is no longer detectable in follicles at resting stage (telogen). Expression in skin and hair follicle is regulated by HOXC13 and by GATA3. Belongs to the KRTAP type 19 family. molecular_function cellular_component intermediate filament biological_process uc007zvi.1 uc007zvi.2 uc007zvi.3 
ENSMUST00000076194.6 Spink7 ENSMUST00000076194.6 serine peptidase inhibitor, Kazal type 7 (putative) (from RefSeq NM_001001803.4) ENSMUST00000076194.1 ENSMUST00000076194.2 ENSMUST00000076194.3 ENSMUST00000076194.4 ENSMUST00000076194.5 Ecg2 F8WGH2 ISK7_MOUSE NM_001001803 Q6IE32 uc012bdx.1 uc012bdx.2 uc012bdx.3 Probable serine protease inhibitor. Secreted Sequence=CAE51413.1; Type=Erroneous gene model prediction; Evidence=; serine-type endopeptidase inhibitor activity extracellular region negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc012bdx.1 uc012bdx.2 uc012bdx.3 
ENSMUST00000076195.7 Gm49359 ENSMUST00000076195.7 Nucleus (from UniProt A0A1Y7VP04) A0A1Y7VP04 A0A1Y7VP04_MOUSE BC115966 ENSMUST00000076195.1 ENSMUST00000076195.2 ENSMUST00000076195.3 ENSMUST00000076195.4 ENSMUST00000076195.5 ENSMUST00000076195.6 Gm49359 Zfp935 uc288npt.1 uc288npt.2 Nucleus nucleic acid binding cellular_component regulation of transcription, DNA-templated uc288npt.1 uc288npt.2 
ENSMUST00000076206.11 Prdm13 ENSMUST00000076206.11 May be involved in transcriptional regulation. Is required for the differentiation of Kiss1-expressing neurons in the arcuate (Arc) nucleus of the hypothalamus. Is a critical regulator of GABAergic cell fate in the cerebellum, required for normal postnatal cerebellar development (PubMed:34730112). (from UniProt E9PZZ1) B1AV74 BC017632 E9PZZ1 ENSMUST00000076206.1 ENSMUST00000076206.10 ENSMUST00000076206.2 ENSMUST00000076206.3 ENSMUST00000076206.4 ENSMUST00000076206.5 ENSMUST00000076206.6 ENSMUST00000076206.7 ENSMUST00000076206.8 ENSMUST00000076206.9 PRD13_MOUSE uc290lka.1 uc290lka.2 May be involved in transcriptional regulation. Is required for the differentiation of Kiss1-expressing neurons in the arcuate (Arc) nucleus of the hypothalamus. Is a critical regulator of GABAergic cell fate in the cerebellum, required for normal postnatal cerebellar development (PubMed:34730112). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9PZZ1-1; Sequence=Displayed; Name=2; IsoId=E9PZZ1-2; Sequence=VSP_042506; Expressed in the brain, hypothalamus, and embryonic nose and brain tissues. Expression is observed in the cerebellum at 12.5- 14.5 days post coitum (dpc). Transcripts are detected prominently in the ventricular zone of both the cerebellar vermis and hemispheres. Belongs to the class V-like SAM-binding methyltransferase superfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus methyltransferase activity histone methylation transferase activity neurogenesis chromatin DNA binding methylation histone methyltransferase activity sequence-specific DNA binding positive regulation of transcription, DNA-templated metal ion binding uc290lka.1 uc290lka.2 
ENSMUST00000076212.4 Abtb2 ENSMUST00000076212.4 ankyrin repeat and BTB domain containing 2 (from RefSeq NM_178890.3) ABTB2_MOUSE ENSMUST00000076212.1 ENSMUST00000076212.2 ENSMUST00000076212.3 NM_178890 Q7TQI7 uc008lix.1 uc008lix.2 May be involved in the initiation of hepatocyte growth. nucleus nucleoplasm protein heterodimerization activity cellular response to toxic substance uc008lix.1 uc008lix.2 
ENSMUST00000076219.7 Pum3 ENSMUST00000076219.7 pumilio RNA-binding family member 3, transcript variant 2 (from RefSeq NR_131940.2) D19Bwg1357e ENSMUST00000076219.1 ENSMUST00000076219.2 ENSMUST00000076219.3 ENSMUST00000076219.4 ENSMUST00000076219.5 ENSMUST00000076219.6 Kiaa0020 NR_131940 PUM3_MOUSE Pum3 Q6A0E6 Q8BKS9 Q8BU15 uc008hby.1 uc008hby.2 uc008hby.3 uc008hby.4 uc008hby.5 uc008hby.6 This gene encodes a member of the evolutionarily conserved Pumilio and Fem-3 mRNA-binding factor family of proteins, which are characterized by tandem 36 amino acid pumilio homolog domains and which function in diverse biological processes. This protein belongs to a group of atypical Pumilio and Fem-3 mRNA-binding factor proteins, whose members are distinguished from other Pumilio and Fem-3 mRNA-binding factor proteins by a novel protein fold with 11 pumilio homolog domains and an ability to bind to DNA and single- and double-stranded RNA without sequence specificity. In mouse, lower levels of gene expression have been correlated with increased testicular germ cell tumors. A pseudogene of this gene is found on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells. Interacts with PARP1 (via catalytic domain). Nucleus, nucleolus Nucleus, nucleoplasm Chromosome Note=Localizes predominantly in the nucleolus with minor punctate signals in the nucleoplasm. In the adult eye, expressed primarily in retinal ganglion cells and, to a lesser extent, in the pigmented cells. A 90 degree bend between Pumilio repeats 3 and 4 gives rise to a L-shaped protein. Sequence=BAC34427.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC40135.1; Type=Frameshift; Evidence=; Sequence=BAE24873.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; DNA binding RNA binding nucleus nucleoplasm chromosome nucleolus endoplasmic reticulum regulation of protein ADP-ribosylation uc008hby.1 uc008hby.2 uc008hby.3 uc008hby.4 uc008hby.5 uc008hby.6 
ENSMUST00000076226.13 Herc2 ENSMUST00000076226.13 HECT and RLD domain containing E3 ubiquitin protein ligase 2, transcript variant 1 (from RefSeq NM_010418.2) E9PZT6 ENSMUST00000076226.1 ENSMUST00000076226.10 ENSMUST00000076226.11 ENSMUST00000076226.12 ENSMUST00000076226.2 ENSMUST00000076226.3 ENSMUST00000076226.4 ENSMUST00000076226.5 ENSMUST00000076226.6 ENSMUST00000076226.7 ENSMUST00000076226.8 ENSMUST00000076226.9 HERC2_MOUSE Herc2 Jdf2 Kiaa0393 NM_010418 O88473 Q3TRJ8 Q3TS47 Q3TST2 Q3UFQ6 Q3URH7 Q4U2R1 Q5DU32 Q7TPR5 Q80VV7 Q9QYT1 Q9Z168 Q9Z171 Rjs uc009hdv.1 uc009hdv.2 uc009hdv.3 uc009hdv.4 E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage- induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Modulates also iron metabolism by regulating the basal turnover of FBXL5. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence=; Protein modification; protein ubiquitination. Interacts (when phosphorylated at Thr-4829 and sumoylated) with RNF8 (via FHA domain); this interaction increases after ionising radiation (IR) treatment. Interacts with XPA. Interacts with NEURL4. Via its interaction with NEURL4, may indirectly interact with CCP110 and CEP97. Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Nucleus Note=Recruited to sites of DNA damage in response to ionising radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q4U2R1-1; Sequence=Displayed; Name=2 ; IsoId=Q4U2R1-2; Sequence=VSP_051975; Highest levels are found in brain and testis with lower levels in heart, lung, liver, skeletal muscle and kidney. Little expression detected in spleen. The ZZ-type zinc finger mediates binding to SUMO1, and at low level SUMO2. The RCC1 repeats are grouped into three seven-bladed beta- propeller regions. Phosphorylation at Thr-4829 is required for interaction with RNF8. Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs), promoting the interaction with RNF8. Note=Defects in Herc2 are the cause of the runty, jerky, sterile phenotype (rjs), also known as the juvenile development and fertility phenotype (jfd2), which is characterized by reduced size, jerky gait, fertility problems including spermatocyte and oocyte abnormalities, defective maternal behavior and reduced lifespan with juvenile lethality. ubiquitin-protein transferase activity nucleus cytoplasm mitochondrial inner membrane centriole cytoskeleton DNA repair cellular response to DNA damage stimulus spermatogenesis zinc ion binding protein ubiquitination transferase activity ubiquitin protein ligase binding SUMO binding proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding uc009hdv.1 uc009hdv.2 uc009hdv.3 uc009hdv.4 
ENSMUST00000076228.3 Rcc1l ENSMUST00000076228.3 reculator of chromosome condensation 1 like (from RefSeq NM_033572.2) ENSMUST00000076228.1 ENSMUST00000076228.2 NM_033572 Q9CYF5 RCC1L_MOUSE Rcc1l Wbscr16 uc008zvc.1 uc008zvc.2 uc008zvc.3 uc008zvc.4 Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876). Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (By similarity). Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct (By similarity). Interacts with OPA1; this interaction is direct (PubMed:28746876). Mitochondrion inner membrane At E8.5, broadly expressed in yolk sac placenta, decidua, and embryo, with highest levels found in the trophoblast giant cells (TGCs) and ectoplacental cone (at protein level). The RCC1-like repeats assemble into a circular seven-bladed beta propeller structure. Each blade is composed of four antiparallel beta-strands with loops between each strand. guanyl-nucleotide exchange factor activity Ran guanyl-nucleotide exchange factor activity protein binding mitochondrion mitochondrial inner membrane membrane rRNA binding mitochondrial membrane positive regulation of mitochondrial translation mitochondrial membrane fusion uc008zvc.1 uc008zvc.2 uc008zvc.3 uc008zvc.4 
ENSMUST00000076236.7 Carmil3 ENSMUST00000076236.7 capping protein regulator and myosin 1 linker 3, transcript variant 6 (from RefSeq NM_001374105.1) CARL3_MOUSE ENSMUST00000076236.1 ENSMUST00000076236.2 ENSMUST00000076236.3 ENSMUST00000076236.4 ENSMUST00000076236.5 ENSMUST00000076236.6 Lrrc16b NM_001374105 Q3UFQ8 Q6KAP3 uc007tyo.1 uc007tyo.2 uc007tyo.3 Cytoplasm Cell membrane The C-terminus is necessary for localization to the cell membrane. Belongs to the CARMIL family. Sequence=BAD21414.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence=; molecular_function cytoplasm plasma membrane biological_process membrane uc007tyo.1 uc007tyo.2 uc007tyo.3 
ENSMUST00000076249.6 Ifit3b ENSMUST00000076249.6 interferon-induced protein with tetratricopeptide repeats 3B (from RefSeq NM_001005858.3) E9PV48 E9PV48_MOUSE ENSMUST00000076249.1 ENSMUST00000076249.2 ENSMUST00000076249.3 ENSMUST00000076249.4 ENSMUST00000076249.5 I830012O16Rik Ifit3b NM_001005858 uc008hgr.1 uc008hgr.2 uc008hgr.3 Belongs to the IFIT family. cytoplasm mitochondrion cytosol cellular response to interferon-alpha identical protein binding defense response to virus uc008hgr.1 uc008hgr.2 uc008hgr.3 
ENSMUST00000076251.7 Zfp865 ENSMUST00000076251.7 zinc finger protein 865, transcript variant 1 (from RefSeq NM_001033383.2) D3Z3M5 ENSMUST00000076251.1 ENSMUST00000076251.2 ENSMUST00000076251.3 ENSMUST00000076251.4 ENSMUST00000076251.5 ENSMUST00000076251.6 NM_001033383 Q3U3I9 ZN865_MOUSE Znf865 uc009ezk.1 uc009ezk.2 uc009ezk.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus metal ion binding uc009ezk.1 uc009ezk.2 uc009ezk.3 
ENSMUST00000076263.2 Or8k30 ENSMUST00000076263.2 olfactory receptor family 8 subfamily K member 30 (from RefSeq NM_146406.2) A2AK60 A2AK60_MOUSE ENSMUST00000076263.1 NM_146406 Olfr1076 Or8k30 uc008kmm.1 uc008kmm.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kmm.1 uc008kmm.2 
ENSMUST00000076264.8 Zfp512 ENSMUST00000076264.8 zinc finger protein 512, transcript variant 1 (from RefSeq NM_172993.3) ENSMUST00000076264.1 ENSMUST00000076264.2 ENSMUST00000076264.3 ENSMUST00000076264.4 ENSMUST00000076264.5 ENSMUST00000076264.6 ENSMUST00000076264.7 Kiaa1805 NM_172993 Q3U365 Q3UDU3 Q3UJQ0 Q5FWY0 Q69Z99 Q8BJF3 ZN512_MOUSE Znf512 uc008wyg.1 uc008wyg.2 uc008wyg.3 uc008wyg.4 uc008wyg.5 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAD32545.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding nucleus biological_process metal ion binding uc008wyg.1 uc008wyg.2 uc008wyg.3 uc008wyg.4 uc008wyg.5 
ENSMUST00000076265.13 Upf3b ENSMUST00000076265.13 UPF3 regulator of nonsense transcripts homolog B (yeast) (from RefSeq NM_026573.3) ENSMUST00000076265.1 ENSMUST00000076265.10 ENSMUST00000076265.11 ENSMUST00000076265.12 ENSMUST00000076265.2 ENSMUST00000076265.3 ENSMUST00000076265.4 ENSMUST00000076265.5 ENSMUST00000076265.6 ENSMUST00000076265.7 ENSMUST00000076265.8 ENSMUST00000076265.9 NM_026573 Q3ULL6 Q3ULL6_MOUSE Upf3b uc009sye.1 uc009sye.2 uc009sye.3 Belongs to the RENT3 family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nucleic acid binding mRNA binding nucleus nucleolus cytoplasm microtubule organizing center cytosol response to unfolded protein exon-exon junction complex positive regulation of translation uc009sye.1 uc009sye.2 uc009sye.3 
ENSMUST00000076270.13 Rabep1 ENSMUST00000076270.13 rabaptin, RAB GTPase binding effector protein 1, transcript variant 1 (from RefSeq NM_019400.3) A1L322 ENSMUST00000076270.1 ENSMUST00000076270.10 ENSMUST00000076270.11 ENSMUST00000076270.12 ENSMUST00000076270.2 ENSMUST00000076270.3 ENSMUST00000076270.4 ENSMUST00000076270.5 ENSMUST00000076270.6 ENSMUST00000076270.7 ENSMUST00000076270.8 ENSMUST00000076270.9 NM_019400 O35551 Q5QNU3 Q99L08 Q9CRP3 Q9EQF9 Q9JI94 RABE1_MOUSE Rab5ep Rabpt5 Rabpt5a uc007jwr.1 uc007jwr.2 uc007jwr.3 uc007jwr.4 uc007jwr.5 Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (PubMed:25405894). Heterodimer with RABGEF1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with TSC2 (By similarity). Interacts with GGA1 (via GAE domain), GGA2 (via GAE domain) and GGA3 (via GAE domain) (By similarity). Interacts with AP1G1 (via GAE domain) (By similarity). Interacts with AP1G2 (via GAE domain) (By similarity). Interacts with ECPAS (By similarity). Interacts with KCNH1 (PubMed:22841712). Interacts with PKD1 (via C-terminal domain) and GGA1; the interactions recruit PKD1:PKD2 complex to GGA1 and ARL3 at trans-Golgi network (PubMed:25405894). Interacts with KCNH1 (By similarity). Cytoplasm Early endosome Recycling endosome Cytoplasmic vesicle Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Rabaptin-5; IsoId=O35551-1; Sequence=Displayed; Name=2; Synonyms=Rabaptin-5gamma; IsoId=O35551-2; Sequence=VSP_010452; Name=3; Synonyms=Rabaptin-5delta; IsoId=O35551-3; Sequence=VSP_010453; Name=4; IsoId=O35551-4; Sequence=VSP_010454, VSP_010455; Name=5; IsoId=O35551-5; Sequence=VSP_010456, VSP_010457; Name=6; IsoId=O35551-6; Sequence=VSP_025444; Proteolytic cleavage by caspases in apoptotic cells causes loss of endosome fusion activity. [Isoform 5]: May be due to an intron retention. Belongs to the rabaptin family. Sequence=AAH03921.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; GTPase activator activity protein binding cytoplasm endosome early endosome Golgi to plasma membrane transport endocytosis apoptotic process signal transduction growth factor activity protein transport vesicle-mediated transport protein domain specific binding endocytic vesicle cytoplasmic vesicle macromolecular complex protein homodimerization activity intracellular membrane-bounded organelle positive regulation of GTPase activity recycling endosome protein localization to ciliary membrane uc007jwr.1 uc007jwr.2 uc007jwr.3 uc007jwr.4 uc007jwr.5 
ENSMUST00000076272.5 Abca15 ENSMUST00000076272.5 ATP-binding cassette, sub-family A member 15 (from RefSeq NM_177213.3) Abca15 ENSMUST00000076272.1 ENSMUST00000076272.2 ENSMUST00000076272.3 ENSMUST00000076272.4 NM_177213 Q6XBG2 Q6XBG2_MOUSE uc009jmp.1 uc009jmp.2 Membrane ; Multi- pass membrane protein nucleotide binding hematopoietic progenitor cell differentiation lipid transporter activity ATP binding lipid transport membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances intracellular membrane-bounded organelle transmembrane transport uc009jmp.1 uc009jmp.2 
ENSMUST00000076276.5 Cnfn ENSMUST00000076276.5 cornifelin, transcript variant 2 (from RefSeq NM_001081375.1) CNFN_MOUSE ENSMUST00000076276.1 ENSMUST00000076276.2 ENSMUST00000076276.3 ENSMUST00000076276.4 NM_001081375 Q6PCW6 uc009fsl.1 uc009fsl.2 uc009fsl.3 Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Directly or indirectly cross-linked to CE proteins loricin and involucrin (IVL). Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope. Belongs to the cornifelin family. cornified envelope molecular_function cytoplasm biological_process keratinization uc009fsl.1 uc009fsl.2 uc009fsl.3 
ENSMUST00000076316.6 Arhgap10 ENSMUST00000076316.6 Rho GTPase activating protein 10, transcript variant 7 (from RefSeq NR_156496.1) ENSMUST00000076316.1 ENSMUST00000076316.2 ENSMUST00000076316.3 ENSMUST00000076316.4 ENSMUST00000076316.5 NR_156496 Q6Y5D6 Q6Y5D7 Q6Y5D8 Q99MT3 Q99MT4 RHG10_MOUSE uc009mhm.1 uc009mhm.2 uc009mhm.3 GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11238453). Also converts Cdc42 to an inactive GDP-bound state (By similarity). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases (PubMed:11238453). Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (PubMed:15471851). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (By similarity). Interacts with PKN3 (By similarity). Interacts with caspase- activated PAK2 proteolytic fragment PAK-2p34; the interaction does not affect ARHGAP10 GTPase activation activity towards RHOA and CDC42 (PubMed:15471851). Interacts via its SH3 domain with PTK2/FAK1. Interacts with PTK2B/PYK2; the interaction negatively regulates ARHGAP10 GTPase-activating activity (PubMed:11238453). Interacts with MICAL1 and WDR44; complex formation might transit from GRAF2/ARHGAP10- MICAL1 to GRAF2/ARHGAP10-WDR44 complexes (By similarity). Q6Y5D8; PRO_0000304927 [Q29502]: PAK2; Xeno; NbExp=3; IntAct=EBI-4396535, EBI-4406512; Q6Y5D8-1; PRO_0000304927 [Q29502]: PAK2; Xeno; NbExp=4; IntAct=EBI-4396677, EBI-4406512; Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Endosome membrane Note=Association to cell membrane is dependent on PH domain. Colocalized with MICAL1, RAB8A, RAB8B and RAB10 on endosomal tubules (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=PS-GAP-a, PSGAP-m; IsoId=Q6Y5D8-1; Sequence=Displayed; Name=2; Synonyms=PS-GAP-b; IsoId=Q6Y5D8-2; Sequence=VSP_028128; Name=3; Synonyms=PS-GAP-c; IsoId=Q6Y5D8-3; Sequence=VSP_028129; Name=4; Synonyms=PS-GAP-s, PSGAP-s; IsoId=Q6Y5D8-4; Sequence=VSP_028127; High levels of expression in brain, testes, liver, heart and kidney. The BAR domain is important to associate RAB8A (or RAB8B) and RAB10 to endosomal membrane to promote tubule extension. The BAR domain is also important to recruit WDR44 to endosomal tubules. Phosphorylated on tyrosine residues, probably involving PTK2B/PYK2. GTPase activator activity protein binding cytoplasm cytosol plasma membrane cytoskeleton organization signal transduction membrane negative regulation of apoptotic process positive regulation of GTPase activity perinuclear region of cytoplasm uc009mhm.1 uc009mhm.2 uc009mhm.3 
ENSMUST00000076325.12 Mef2a ENSMUST00000076325.12 myocyte enhancer factor 2A, transcript variant 3 (from RefSeq NM_001291192.1) ENSMUST00000076325.1 ENSMUST00000076325.10 ENSMUST00000076325.11 ENSMUST00000076325.2 ENSMUST00000076325.3 ENSMUST00000076325.4 ENSMUST00000076325.5 ENSMUST00000076325.6 ENSMUST00000076325.7 ENSMUST00000076325.8 ENSMUST00000076325.9 MEF2A_MOUSE NM_001291192 Q3V155 Q4VA09 Q60929 Q6P8Q3 uc009hij.1 uc009hij.2 uc009hij.3 uc009hij.4 uc009hij.5 Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter (By similarity). Binds DNA as a homo- or heterodimer. Dimerizes with MEF2D. Interacts with HDAC7. Interacts with PIAS1; the interaction enhances sumoylation. Interacts with HDAC4, HDAC9 and SLC2A4RG. Interacts (via the N-terminal) with MAPK7; the interaction results in the phosphorylation and transcriptional activity of MEF2A (By similarity). Q60929; P12979: Myog; NbExp=2; IntAct=EBI-2639094, EBI-7132875; Q60929; P70257-2: Nfix; NbExp=2; IntAct=EBI-2639094, EBI-2639084; Nucleus. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q60929-1; Sequence=Displayed; Name=2; IsoId=Q60929-2; Sequence=VSP_026031; Name=3; IsoId=Q60929-3; Sequence=VSP_026060, VSP_026031; Widely expressed though mainly restricted to skeletal and cardiac muscle, brain, neurons and lymphocytes. Differentially expressed depending on if isoforms contain the beta domain or not, with the total expression of the beta domain-lacking isoforms vastly exceding that of the beta domain-containing isoforms. Isoforms containing the beta domain are expressed primarily in skeletal and cardiac muscle and in brain. Also present in lung and testis. Splicing to include the beta domain is induced in differentiating myocytes. Isoforms lacking the beta domain are expressed less abundantly in skeletal muscle, brain and lymphocytes, and are uniquely found in ovary, liver, spleen and kidney. In embryos, the beta domain- containing and beta domain-lacking isoforms are equally expressed. Also expressed cerebellar granule neurons and other regions of the CNS. Highest levels in the olfactory bulb, cortex, hippocampus, thalamus and cerebellum. In the developing cerebellum, increasing levels after birth. The majority of this increase occurs around postnataL day 9 reaching a peak at postnatal day 15-18 which is maintained in adults. The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity. Constitutive phosphorylation on Ser-406 promotes Lys-401 sumoylation thus preventing acetylation at this site. Dephosphorylation on Ser-406 by PPP3CA upon neuron depolarization promotes a switch from sumoylation to acetylation on residue Lys-403 leading to inhibition of dendrite claw differentiation. Phosphorylation on Thr-312 and Thr-319 are the main sites involved in p38 MAPK signaling and activate transcription. Phosphorylated on these sites by MAPK14/p38alpha and MAPK11/p38beta, but not by MAPK13/p38delta nor by MAPK12/p38gamma. Phosphorylation on Ser-408 by CDK5 induced by neurotoxicity inhibits MEF2A transcriptional activation leading to apoptosis of cortical neurons. Phosphorylation on Thr-312, Thr-319 and Ser-355 can be induced by EGF (By similarity). Isoform 3 is phosphorylated on Ser-98 and Thr- 108. Sumoylation on Lys-401 is enhanced by PIAS1 and represses transcriptional activity. Phosphorylation on Ser-406 is required for sumoylation. Has no effect on nuclear location nor on DNA binding. Sumoylated with SUMO1 and, to a lesser extent with SUMO2 and SUMO3. PIASx facilitates sumoylation in postsynaptic dendrites in the cerebellar cortex and promotes their morphogenesis (By similarity). Acetylation on Lys-401 activates transcriptional activity. Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation. Hyperacetylation by p300 leads to enhanced cardiac myocyte growth and heart failure (By similarity). Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 3 and caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation (By similarity). Belongs to the MEF2 family. mitochondrial genome maintenance negative regulation of transcription from RNA polymerase II promoter MAPK cascade nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus nucleoplasm transcription factor complex cytosol transcription, DNA-templated regulation of transcription, DNA-templated apoptotic process multicellular organism development nervous system development heart development transcription factor binding positive regulation of cardiac muscle hypertrophy protein kinase binding cell differentiation activating transcription factor binding histone acetyltransferase binding histone deacetylase binding sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import SMAD binding protein heterodimerization activity protein dimerization activity mitochondrion distribution dendrite morphogenesis ventricular cardiac myofibril assembly cardiac conduction ERK5 cascade cellular response to calcium ion uc009hij.1 uc009hij.2 uc009hij.3 uc009hij.4 uc009hij.5 
ENSMUST00000076349.12 Gria3 ENSMUST00000076349.12 glutamate receptor, ionotropic, AMPA3 (alpha 3), transcript variant 1 (from RefSeq NM_016886.5) A2VDF4 ENSMUST00000076349.1 ENSMUST00000076349.10 ENSMUST00000076349.11 ENSMUST00000076349.2 ENSMUST00000076349.3 ENSMUST00000076349.4 ENSMUST00000076349.5 ENSMUST00000076349.6 ENSMUST00000076349.7 ENSMUST00000076349.8 ENSMUST00000076349.9 GRIA3_MOUSE Glur3 Kiaa4184 NM_016886 Q5DTJ0 Q9Z2W9 uc009tam.1 uc009tam.2 uc009tam.3 uc009tam.4 uc009tam.5 This gene encodes a multi-pass transmembrane protein that forms a homotetramer or heterotetramer in neuronal cells. The encoded protein is a ligand-gated ion channel that responds to the neurotransmitter L-glutamate to promote synaptic transmission. Deficiency of this gene leads to behavioral phenotypes. The transcript is subject to RNA editing at codon 769 (AGA->GGA; R->G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with PRKCABP, GRIP1 and GRIP2 (By similarity). Found in a complex with GRIA1, GRIA2, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 (By similarity). Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi- pass membrane protein Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression. Event=Alternative splicing; Named isoforms=2; Name=Flip; IsoId=Q9Z2W9-1; Sequence=Displayed; Name=Flop; IsoId=Q9Z2W9-2; Sequence=Not described; The M4 transmembrane segment mediates tetramerization and is required for cell surface expression. Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-615 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-841 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity). The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily. Sequence=BAD90527.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; beta-amyloid binding regulation of receptor recycling ionotropic glutamate receptor activity AMPA glutamate receptor activity ion channel activity protein binding plasma membrane ion transport glutamate receptor activity postsynaptic density ligand-gated ion channel activity membrane integral component of membrane cell junction PDZ domain binding dendrite asymmetric synapse AMPA glutamate receptor complex macromolecular complex ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic signaling receptor activity neuronal cell body synaptic cleft terminal bouton dendritic spine dendritic shaft perikaryon synapse postsynaptic membrane modulation of synaptic transmission regulation of postsynaptic membrane potential postsynaptic density membrane glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane integral component of postsynaptic density membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc009tam.1 uc009tam.2 uc009tam.3 uc009tam.4 uc009tam.5 
ENSMUST00000076352.8 Serpinb1a ENSMUST00000076352.8 serine (or cysteine) peptidase inhibitor, clade B, member 1a (from RefSeq NM_025429.2) ENSMUST00000076352.1 ENSMUST00000076352.2 ENSMUST00000076352.3 ENSMUST00000076352.4 ENSMUST00000076352.5 ENSMUST00000076352.6 ENSMUST00000076352.7 ILEUA_MOUSE NM_025429 Q3TV23 Q5SUV7 Q9D0S8 Q9D154 Q9D7S8 Serpinb1 uc007pzu.1 uc007pzu.2 Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:17664292, PubMed:21683252, PubMed:21248149, PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection (PubMed:17664292). These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of granzyme H (PubMed:12189154). During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). In addition, promotes the proliferation of beta-cells when secreted (PubMed:26701651). Monomer. Interacts (via C-terminus) with CASP1 and CASP4 (via CARD domain); these interactions regulate the activity of inflammatory caspases. Secreted Cytoplasm Cytolytic granule Early endosome Ubiquitous with higher expression in pancreas, spleen and bone marrow. Mutant mice do not differ from wild-type in growth, litter size or life span when maintained in a specific pathogen-free environement (PubMed:17664292). However, they have increased mortality in association with late-onset failed bacterial clearance, and specifically increased neutrophil death (PubMed:17664292, PubMed:30692621). Mutant mice also show a severe defect in the bone marrow reserve of mature neutrophils demonstrating a key role for in cellular homeostasis (PubMed:21683252, PubMed:21248149). In addition, Serpinb1a-deficiency leads to maladaptive beta-cell proliferation in insulin-resistant states (PubMed:26701651). Belongs to the serpin family. Ov-serpin subfamily. Sequence=BAB23335.1; Type=Frameshift; Evidence=; Sequence=CAI25648.1; Type=Erroneous gene model prediction; Evidence=; serine-type endopeptidase inhibitor activity protein binding extracellular region extracellular space cytoplasm inflammatory response negative regulation of peptidase activity negative regulation of endopeptidase activity cellular homeostasis peptidase inhibitor activity regulation of protein catabolic process type B pancreatic cell proliferation regulation of innate immune response negative regulation of interleukin-1 beta secretion uc007pzu.1 uc007pzu.2 
ENSMUST00000076354.13 Tspan7 ENSMUST00000076354.13 tetraspanin 7 (from RefSeq NM_019634.2) ENSMUST00000076354.1 ENSMUST00000076354.10 ENSMUST00000076354.11 ENSMUST00000076354.12 ENSMUST00000076354.2 ENSMUST00000076354.3 ENSMUST00000076354.4 ENSMUST00000076354.5 ENSMUST00000076354.6 ENSMUST00000076354.7 ENSMUST00000076354.8 ENSMUST00000076354.9 Mxs1 NM_019634 O88429 Q62283 Q9DBS3 TSN7_MOUSE Tm4sf2 uc009sqm.1 uc009sqm.2 uc009sqm.3 May be involved in cell proliferation and cell motility. Membrane; Multi-pass membrane protein. Belongs to the tetraspanin (TM4SF) family. Sequence=AAC34579.1; Type=Erroneous initiation; Evidence=; Sequence=BAA05493.1; Type=Erroneous initiation; Evidence=; integral component of plasma membrane membrane integral component of membrane uc009sqm.1 uc009sqm.2 uc009sqm.3 
ENSMUST00000076364.6 Rpl10-ps3 ENSMUST00000076364.6 Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes (PubMed:36517592). May play a role in the embryonic brain development (By similarity). (from UniProt Q6ZWV3) BC092383 ENSMUST00000076364.1 ENSMUST00000076364.2 ENSMUST00000076364.3 ENSMUST00000076364.4 ENSMUST00000076364.5 P45634 Q569M8 Q5M9K8 Q6ZWV3 Qm RL10_MOUSE Rpl10 uc292hcn.1 uc292hcn.2 Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes (PubMed:36517592). May play a role in the embryonic brain development (By similarity). Component of the large ribosomal subunit (PubMed:36517592). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:36517592). The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S) (PubMed:36517592). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:36517592). Cytoplasm Citrullinated by PADI4. Ufmylated by UFL1. Belongs to the universal ribosomal protein uL16 family. ribosomal large subunit assembly negative regulation of transcription from RNA polymerase II promoter structural constituent of ribosome nucleus cytoplasm endoplasmic reticulum cytosol ribosome translation regulation of translation multicellular organism development cytosolic large ribosomal subunit macromolecular complex negative regulation of apoptotic process translation regulator activity synapse liver regeneration embryonic brain development smooth endoplasmic reticulum uc292hcn.1 uc292hcn.2 
ENSMUST00000076372.5 Sf3b4 ENSMUST00000076372.5 splicing factor 3b, subunit 4 (from RefSeq NM_153053.4) ENSMUST00000076372.1 ENSMUST00000076372.2 ENSMUST00000076372.3 ENSMUST00000076372.4 NM_153053 Q8QZY9 SF3B4_MOUSE uc008qme.1 uc008qme.2 uc008qme.3 uc008qme.4 This gene encodes one of the subunits of splicing factor 3B. A similar gene in human encodes a protein that cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes, and also belongs with the minor U12-dependent spliceosome. [provided by RefSeq, May 2015]. ##Evidence-Data-START## Transcript exon combination :: AK047751.1, BC026567.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre- mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs. Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Part of the SF3B subcomplex of the 17S U2 SnRNP complex. SF3B associates with the splicing subcomplex SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). SF3B4 has been found in complex spliceosome 'B' and 'C' as well. Component of the minor (U12-type spliceosome) spliceosome. Found in a complex with PRMT9, SF3B2 and SF3B4. Nucleus Belongs to the SF3B4 family. mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus spliceosomal complex U12-type spliceosomal complex nucleolus mRNA processing RNA splicing positive regulation of mRNA splicing, via spliceosome U2-type precatalytic spliceosome ribonucleoprotein complex splicing factor binding uc008qme.1 uc008qme.2 uc008qme.3 uc008qme.4 
ENSMUST00000076379.8 Csn1s2a ENSMUST00000076379.8 casein alpha s2-like A, transcript variant 1 (from RefSeq NM_007785.2) Csn1s2a Csng ENSMUST00000076379.1 ENSMUST00000076379.2 ENSMUST00000076379.3 ENSMUST00000076379.4 ENSMUST00000076379.5 ENSMUST00000076379.6 ENSMUST00000076379.7 NM_007785 Q547D1 Q547D1_MOUSE uc008xyw.1 uc008xyw.2 uc008xyw.3 uc008xyw.4 Important role in the capacity of milk to transport calcium phosphate. Secreted Belongs to the alpha-casein family. extracellular region uc008xyw.1 uc008xyw.2 uc008xyw.3 uc008xyw.4 
ENSMUST00000076383.8 Fbxw11 ENSMUST00000076383.8 F-box and WD-40 domain protein 11, transcript variant 1 (from RefSeq NM_134015.4) Btrcp2 ENSMUST00000076383.1 ENSMUST00000076383.2 ENSMUST00000076383.3 ENSMUST00000076383.4 ENSMUST00000076383.5 ENSMUST00000076383.6 ENSMUST00000076383.7 FBW1B_MOUSE Fbw1b Fbxw1b NM_134015 Q3TGM9 Q3TLZ8 Q5SRY7 Q8BY90 Q8K022 Q923H0 uc007ijx.1 uc007ijx.2 uc007ijx.3 uc007ijx.4 uc007ijx.5 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11896578). Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S (By similarity). SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation (By similarity). SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription (PubMed:11896578). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (By similarity). SCF(FBXW11) mediates the ubiquitination of IFNAR1 (By similarity). SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1 (By similarity). Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2 (PubMed:18782782). SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (By similarity). SCF(FBXW11) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (By similarity). Protein modification; protein ubiquitination. Self-associates (By similarity). Component of the SCF(FBXW11) complex formed of CUL1, SKP1, RBX1 and a FBXW11 dimer (PubMed:11896578). Interacts with BST2 and USP47 (By similarity). Interacts with TRIM21 (By similarity). Interacts with PER3 (PubMed:15917222). Interacts with INAVA (By similarity). Interacts with REST (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5SRY7-1; Sequence=Displayed; Name=2; IsoId=Q5SRY7-2; Sequence=VSP_039581; Name=3; IsoId=Q5SRY7-3; Sequence=VSP_039580; Name=4; IsoId=Q5SRY7-4; Sequence=VSP_039579; Expression is negatively regulated by Wnt/beta-catenin pathway. The N-terminal D domain mediates homodimerization. Sequence=AAK72095.1; Type=Frameshift; Evidence=; protein polyubiquitination ubiquitin-protein transferase activity protein binding nucleus cytoplasm centrosome cytosol protein dephosphorylation cell cycle Wnt signaling pathway protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein destabilization regulation of circadian rhythm positive regulation of circadian rhythm proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated protein dimerization activity rhythmic process negative regulation of NIK/NF-kappaB signaling ubiquitin protein ligase activity uc007ijx.1 uc007ijx.2 uc007ijx.3 uc007ijx.4 uc007ijx.5 
ENSMUST00000076384.6 Ces2f ENSMUST00000076384.6 carboxylesterase 2F, transcript variant 1 (from RefSeq NM_001079865.2) 2310038E17Rik Ces2f ENSMUST00000076384.1 ENSMUST00000076384.2 ENSMUST00000076384.3 ENSMUST00000076384.4 ENSMUST00000076384.5 NM_001079865 Q08ED5 Q08ED5_MOUSE uc009nbi.1 uc009nbi.2 uc009nbi.3 Belongs to the type-B carboxylesterase/lipase family. extracellular space biological_process hydrolase activity carboxylic ester hydrolase activity uc009nbi.1 uc009nbi.2 uc009nbi.3 
ENSMUST00000076431.13 Pmpca ENSMUST00000076431.13 peptidase (mitochondrial processing) alpha, transcript variant 6 (from RefSeq NR_184781.1) ENSMUST00000076431.1 ENSMUST00000076431.10 ENSMUST00000076431.11 ENSMUST00000076431.12 ENSMUST00000076431.2 ENSMUST00000076431.3 ENSMUST00000076431.4 ENSMUST00000076431.5 ENSMUST00000076431.6 ENSMUST00000076431.7 ENSMUST00000076431.8 ENSMUST00000076431.9 Inpp5e MPPA_MOUSE NR_184781 Q3TF19 Q9DC61 uc008ive.1 uc008ive.2 uc008ive.3 Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit. Mitochondrion matrix Mitochondrion inner membrane Belongs to the peptidase M16 family. Does not seem to have protease activity as it lacks the zinc- binding site. catalytic activity endopeptidase activity metalloendopeptidase activity mitochondrion mitochondrial inner membrane mitochondrial matrix proteolysis protein processing involved in protein targeting to mitochondrion membrane mitochondrial processing peptidase complex metal ion binding metallopeptidase activity uc008ive.1 uc008ive.2 uc008ive.3 
ENSMUST00000076442.12 Plec ENSMUST00000076442.12 plectin, transcript variant 6 (from RefSeq NM_201389.2) E9QN87 ENSMUST00000076442.1 ENSMUST00000076442.10 ENSMUST00000076442.11 ENSMUST00000076442.2 ENSMUST00000076442.3 ENSMUST00000076442.4 ENSMUST00000076442.5 ENSMUST00000076442.6 ENSMUST00000076442.7 ENSMUST00000076442.8 ENSMUST00000076442.9 NM_201389 PLEC_MOUSE Plec1 Q6S384 Q6S389 Q6S394 Q9CS65 Q9QUT2 Q9QXQ8 Q9QXQ9 Q9QXR0 Q9QXR1 Q9QXR2 Q9QXR3 Q9QXR4 Q9QXR5 Q9QXR6 Q9QXR7 Q9QXR8 Q9QXR9 Q9QXS0 Q9QXS1 Q9QXS2 Q9QXS3 uc007wiw.1 uc007wiw.2 uc007wiw.3 uc007wiw.4 Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as 'hemidesmosomal protein 1' or 'plectin 1, intermediate filament binding 500kDa'. These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). It has been shown that the short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (human variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011]. Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics. Homodimer or homotetramer (By similarity). Interacts (via actin-binding domain) with SYNE3 (PubMed:16330710). Interacts (via calponin-homology (CH) 1 domain) with VIM (via rod region) (PubMed:15128297). Interacts (via N-terminus) with DST isoform 2 (via N-terminus) (PubMed:19932097). Interacts with FER (PubMed:12200133). Interacts with TOR1A (PubMed:18827015). Interacts with ANK3 (By similarity). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (PubMed:21745462). [Isoform PLEC-0,1C]: Interacts with KRT14, heterodimers consisting of KRT8 and KRT18, heterodimers consisting of KRT5 and KRT14, heterodimers consisting of KRT14 and KRT15, and heterodimers consisting of KRT1 and KRT10 (PubMed:24940650). Interacts with DES and VIM (PubMed:24940650). Q9QXS1; Q9D2G2: Dlst; NbExp=2; IntAct=EBI-774583, EBI-773210; Q9QXS1; P35486: Pdha1; NbExp=2; IntAct=EBI-774583, EBI-773613; Q9QXS1-3; P62158: CALM3; Xeno; NbExp=11; IntAct=EBI-16145475, EBI-397435; Q9QXS1-3; P16144: ITGB4; Xeno; NbExp=4; IntAct=EBI-16145475, EBI-948678; Cytoplasm, cytoskeleton Cell junction, hemidesmosome Event=Alternative splicing; Named isoforms=16; Name=PLEC-1,2A; IsoId=Q9QXS1-1; Sequence=Displayed; Name=PLEC-1; IsoId=Q9QXS1-2; Sequence=VSP_005048; Name=PLEC-1A; IsoId=Q9QXS1-3; Sequence=VSP_005036, VSP_005045, VSP_005048; Name=PLEC-1B,2A; IsoId=Q9QXS1-4; Sequence=VSP_005037, VSP_005045; Name=PLEC-1B; IsoId=Q9QXS1-5; Sequence=VSP_005037, VSP_005045, VSP_005048; Name=PLEC-0,1C; IsoId=Q9QXS1-6; Sequence=VSP_005039, VSP_005047, VSP_005048; Name=PLEC-0,1C,2A; IsoId=Q9QXS1-7; Sequence=VSP_005039, VSP_005047; Name=PLEC-0,1C,2A,3A; IsoId=Q9QXS1-8; Sequence=VSP_005039, VSP_005047, VSP_005049; Name=PLEC-1D,2A; IsoId=Q9QXS1-9; Sequence=VSP_005032, VSP_005041; Name=PLEC-1D; IsoId=Q9QXS1-10; Sequence=VSP_005032, VSP_005041, VSP_005048; Name=PLEC-1E,2A; IsoId=Q9QXS1-11; Sequence=VSP_005033, VSP_005042; Name=PLEC-1E; IsoId=Q9QXS1-12; Sequence=VSP_005033, VSP_005042, VSP_005048; Name=PLEC-1F; IsoId=Q9QXS1-13; Sequence=VSP_005034, VSP_005043, VSP_005048; Name=PLEC-1G; IsoId=Q9QXS1-14; Sequence=VSP_005038, VSP_005046, VSP_005048; Name=PLEC-1H; IsoId=Q9QXS1-15; Sequence=VSP_005040; Name=PLEC-1I; IsoId=Q9QXS1-16; Sequence=VSP_005035, VSP_005044; Detected in eye lens fiber cells (at protein level) (PubMed:21745462). Expressed at high levels in lung, brain, small intestine, muscle, heart and skin with lower levels found in kidney, liver, uterus, spleen and salivary gland (PubMed:10556294). The N-terminus interacts with actin, the C-terminus with vimentin, desmin, GFAP, cytokeratins, lamin B; whereas both the N- and the C-terminus can bind integrin beta-4. Phosphorylated by CDK1; regulates dissociation from intermediate filaments during mitosis. Isoform PLEC-1A is phosphorylated on Ser-21. Isoform PLEC-1A is phosphorylated on Tyr-26. Belongs to the plakin or cytolinker family. actin binding structural constituent of cytoskeleton protein binding cytoplasm cytosol cytoskeleton brush border focal adhesion response to nutrient cytoskeletal protein binding structural constituent of muscle basal plasma membrane membrane apical plasma membrane sarcoplasm cell junction hemidesmosome ankyrin binding hemidesmosome assembly wound healing sarcolemma contractile fiber intermediate filament cytoskeleton organization intermediate filament cytoskeleton protein N-terminus binding perinuclear region of cytoplasm intermediate filament uc007wiw.1 uc007wiw.2 uc007wiw.3 uc007wiw.4 
ENSMUST00000076443.10 Ggt6 ENSMUST00000076443.10 gamma-glutamyltransferase 6, transcript variant 1 (from RefSeq NM_027819.3) ENSMUST00000076443.1 ENSMUST00000076443.2 ENSMUST00000076443.3 ENSMUST00000076443.4 ENSMUST00000076443.5 ENSMUST00000076443.6 ENSMUST00000076443.7 ENSMUST00000076443.8 ENSMUST00000076443.9 GGT6_MOUSE Ggt6 NM_027819 Q5F245 Q6PDE7 Q9D347 uc007jyw.1 uc007jyw.2 uc007jyw.3 uc007jyw.4 Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors. Reaction=an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]; Xref=Rhea:RHEA:23904, Rhea:RHEA-COMP:9780, Rhea:RHEA-COMP:9795, ChEBI:CHEBI:77644, ChEBI:CHEBI:78597, ChEBI:CHEBI:78599, ChEBI:CHEBI:78608; EC=2.3.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23905; Evidence=; Reaction=glutathione + H2O = L-cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:28807, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:57925, ChEBI:CHEBI:61694; EC=3.4.19.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28808; Evidence=; Reaction=an S-substituted glutathione + H2O = an S-substituted L- cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:59468, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:90779, ChEBI:CHEBI:143103; EC=3.4.19.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59469; Evidence=; Sulfur metabolism; glutathione metabolism. Heterodimer composed of the light and heavy chains. The active site is located in the light chain. Membrane ; Single- pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PDE7-1; Sequence=Displayed; Name=2; IsoId=Q6PDE7-2; Sequence=VSP_030452; Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme. Belongs to the gamma-glutamyltransferase family. Sequence=BAB31233.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAB31233.1; Type=Frameshift; Evidence=; molecular_function proteolysis glutathione metabolic process glutathione biosynthetic process biological_process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups hydrolase activity glutathione hydrolase activity uc007jyw.1 uc007jyw.2 uc007jyw.3 uc007jyw.4 
ENSMUST00000076463.12 Gpr155 ENSMUST00000076463.12 G protein-coupled receptor 155, transcript variant 3 (from RefSeq NM_001276443.1) A2AWR2 A2AWR3 D7RXL9 D7RXM0 ENSMUST00000076463.1 ENSMUST00000076463.10 ENSMUST00000076463.11 ENSMUST00000076463.2 ENSMUST00000076463.3 ENSMUST00000076463.4 ENSMUST00000076463.5 ENSMUST00000076463.6 ENSMUST00000076463.7 ENSMUST00000076463.8 ENSMUST00000076463.9 Gpr155 LYCHS_MOUSE NM_001276443 Q14BN5 Q80UC0 Q8R0W2 uc008kco.1 uc008kco.2 uc008kco.3 uc008kco.4 uc008kco.5 Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway (By similarity). Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disrupt interaction between the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (By similarity). Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition (By similarity). Interacts with the GATOR1 complex; preventing interaction between GATOR1 and KICSTOR; interaction is disrupted upon cholesterol starvation. Lysosome membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Variant 1 ; IsoId=A2AWR3-1; Sequence=Displayed; Name=2; Synonyms=Variant 5 ; IsoId=A2AWR3-2; Sequence=VSP_061976; Name=3; Synonyms=Variant 3 ; IsoId=A2AWR3-3; Sequence=VSP_061978, VSP_061979; Name=4; Synonyms=Variant 2 ; IsoId=A2AWR3-4; Sequence=VSP_061981, VSP_061982; Name=5; Synonyms=Variant 4 ; IsoId=A2AWR3-5; Sequence=VSP_061977, VSP_061980; Widely expressed in adult tissues and during development (PubMed:20537985). In brain, widely distributed in forebrain regions, while it shows a more restricted distribution in the midbrain and hindbrain regions (PubMed:20537985). Expressed at highest level in the lateral part of striatum and hippocampus (PubMed:20537985). molecular_function membrane integral component of membrane intracellular signal transduction cognition transmembrane transport uc008kco.1 uc008kco.2 uc008kco.3 uc008kco.4 uc008kco.5 
ENSMUST00000076470.5 Nlrp4e ENSMUST00000076470.5 NLR family, pyrin domain containing 4E (from RefSeq NM_001004194.2) ENSMUST00000076470.1 ENSMUST00000076470.2 ENSMUST00000076470.3 ENSMUST00000076470.4 NAL4E_MOUSE NM_001004194 Nalp4e Nlrp4 Q66X19 uc009fod.1 uc009fod.2 uc009fod.3 May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Belongs to the NLRP family. nucleotide binding molecular_function ATP binding inflammatory response biological_process uc009fod.1 uc009fod.2 uc009fod.3 
ENSMUST00000076478.2 Krtap2-21 ENSMUST00000076478.2 predicted gene 11937 (from RefSeq NM_001099346.2) ENSMUST00000076478.1 Gm11937 Gm11938 Krtap2-4 NM_001099346 Q9D3H4 Q9D3H4_MOUSE uc007ljg.1 uc007ljg.2 molecular_function cellular_component biological_process keratin filament uc007ljg.1 uc007ljg.2 
ENSMUST00000076493.11 Slc22a21 ENSMUST00000076493.11 solute carrier family 22 (organic cation transporter), member 21, transcript variant 1 (from RefSeq NM_019723.3) ENSMUST00000076493.1 ENSMUST00000076493.10 ENSMUST00000076493.2 ENSMUST00000076493.3 ENSMUST00000076493.4 ENSMUST00000076493.5 ENSMUST00000076493.6 ENSMUST00000076493.7 ENSMUST00000076493.8 ENSMUST00000076493.9 NM_019723 Octn3 Q5SWV0 Q9WTN6 S22AL_MOUSE Slc22a9 uc007ixd.1 uc007ixd.2 uc007ixd.3 Sodium-ion independent, medium affinity carnitine transporter. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 746. Peroxisome membrane ulti-pass membrane protein Predominantly expressed in testis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. nucleotide binding ATP binding peroxisome peroxisomal membrane ion transport carnitine transmembrane transporter activity quaternary ammonium group transmembrane transporter activity quaternary ammonium group transport carnitine transport membrane integral component of membrane transmembrane transporter activity intrinsic component of peroxisomal membrane transmembrane transport carnitine transmembrane transport uc007ixd.1 uc007ixd.2 uc007ixd.3 
ENSMUST00000076500.14 Speer2 ENSMUST00000076500.14 spermatogenesis associated glutamate (E)-rich protein 2, transcript variant 1 (from RefSeq NM_173069.4) E9Q9U2 E9Q9U2_MOUSE ENSMUST00000076500.1 ENSMUST00000076500.10 ENSMUST00000076500.11 ENSMUST00000076500.12 ENSMUST00000076500.13 ENSMUST00000076500.2 ENSMUST00000076500.3 ENSMUST00000076500.4 ENSMUST00000076500.5 ENSMUST00000076500.6 ENSMUST00000076500.7 ENSMUST00000076500.8 ENSMUST00000076500.9 NM_173069 Speer2 uc012ahb.1 uc012ahb.2 molecular_function cellular_component biological_process uc012ahb.1 uc012ahb.2 
ENSMUST00000076501.2 Usp17lb ENSMUST00000076501.2 ubiquitin specific peptidase 17-like B, transcript variant 1 (from RefSeq NM_201409.3) B7ZN74 Dub1a E9Q9U0 E9QMF1 ENSMUST00000076501.1 NM_201409 Q6X3X0 U17PB_MOUSE Usp17lb uc009iwy.1 uc009iwy.2 Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Inhibited by ubiquitin aldehyde. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q9U0-1; Sequence=Displayed; Name=2; IsoId=E9Q9U0-2; Sequence=VSP_058560; Detected in brain, heart, liver, lung, kidney, ovary and spleen. Up-regulated by interleukin-3 (IL-3) in the B-lymphocyte cell line Ba/F3. May also be up-regulated in response to JAK2. Ubiquitinated. [Isoform 2]: May be due to competing acceptor splice site. Belongs to the peptidase C19 family. USP17 subfamily. cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity regulation of apoptotic process uc009iwy.1 uc009iwy.2 
ENSMUST00000076505.4 Pyroxd2 ENSMUST00000076505.4 pyridine nucleotide-disulphide oxidoreductase domain 2 (from RefSeq NM_029011.2) E9QPD2 ENSMUST00000076505.1 ENSMUST00000076505.2 ENSMUST00000076505.3 NM_029011 PYRD2_MOUSE Pyroxd2 Q3U4I7 Q8CAN2 Q9D630 uc008hnu.1 uc008hnu.2 Probable oxidoreductase that may play a role as regulator of mitochondrial function. Interacts with COX5B; this interaction may contribute to localize PYROXD2 to the inner face of the inner mitochondrial membrane. Mitochondrion matrix Note=The import into mitochondria is dependent on TOMM40 and TIMM23. Belongs to the carotenoid/retinoid oxidoreductase family. Sequence=BAE32444.1; Type=Miscellaneous discrepancy; Note=Intron retention between positions 50 and 165.; Evidence=; oxidoreductase activity oxidation-reduction process uc008hnu.1 uc008hnu.2 
ENSMUST00000076521.7 Irf6 ENSMUST00000076521.7 interferon regulatory factor 6 (from RefSeq NM_016851.2) ENSMUST00000076521.1 ENSMUST00000076521.2 ENSMUST00000076521.3 ENSMUST00000076521.4 ENSMUST00000076521.5 ENSMUST00000076521.6 IRF6_MOUSE NM_016851 P97431 Q91VD0 uc007edy.1 uc007edy.2 uc007edy.3 uc007edy.4 Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Interacts with SERPINB5. P97431; P37238: Pparg; NbExp=2; IntAct=EBI-21183505, EBI-5260705; Nucleus Cytoplasm Note=Translocates to nucleus in response to an activating signal. High levels of expression along the medial edge of the fusing palate, tooth buds, hair follicles, genitalia and skin. Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation. Belongs to the IRF family. RNA polymerase II transcription factor activity, sequence-specific DNA binding immune system process DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm cytosol regulation of transcription, DNA-templated cell cycle arrest negative regulation of cell proliferation cell junction cell differentiation keratinocyte differentiation sequence-specific DNA binding skin development keratinocyte proliferation transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell development palate development mammary gland epithelial cell differentiation uc007edy.1 uc007edy.2 uc007edy.3 uc007edy.4 
ENSMUST00000076532.14 Serpinb6a ENSMUST00000076532.14 serine (or cysteine) peptidase inhibitor, clade B, member 6a, transcript variant 4 (from RefSeq NM_001243192.1) ENSMUST00000076532.1 ENSMUST00000076532.10 ENSMUST00000076532.11 ENSMUST00000076532.12 ENSMUST00000076532.13 ENSMUST00000076532.2 ENSMUST00000076532.3 ENSMUST00000076532.4 ENSMUST00000076532.5 ENSMUST00000076532.6 ENSMUST00000076532.7 ENSMUST00000076532.8 ENSMUST00000076532.9 NM_001243192 Q60854 SPB6_MOUSE Serpinb6 Spi3 uc011yyf.1 uc011yyf.2 uc011yyf.3 Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Forms a complex with the monomeric form of beta-tryptase. Cytoplasm Expressed in the inner ear hair cells, keratinocytes of hair follicles and epidermis in abdominal skin. At 13.5 dpc, weakly detected in utricle sensory epithelium but not in hair cells. At 16.5 dpc, more prominently detected in crista hair cells. Hair cell expression is sustained in postnatal mice. In cochlea, detected in cochlear hair cells in embryo and in hair cells and the greater epithelial ridge (GER) region in early postnatal age. Belongs to the serpin family. Ov-serpin subfamily. protease binding serine-type endopeptidase inhibitor activity protein binding extracellular space cytoplasm sensory perception of sound gonad development negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity cellular response to osmotic stress serine protease inhibitor complex uc011yyf.1 uc011yyf.2 uc011yyf.3 
ENSMUST00000076542.2 Or8b52 ENSMUST00000076542.2 olfactory receptor family 8 subfamily B member 52 (from RefSeq NM_001011864.1) ENSMUST00000076542.1 NM_001011864 Olfr917 Or8b52 Q7TRC3 Q7TRC3_MOUSE uc009owx.1 uc009owx.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009owx.1 uc009owx.2 
ENSMUST00000076565.3 Tas2r138 ENSMUST00000076565.3 taste receptor, type 2, member 138 (from RefSeq NM_001001451.1) A0PK79 ENSMUST00000076565.1 ENSMUST00000076565.2 NM_001001451 Q4VHF0 Q7TQA6 T2R38_MOUSE T2r31 Tas2r38 uc009bne.1 uc009bne.2 Putative taste receptor which may play a role in the perception of bitterness. Membrane; Multi-pass membrane protein. Low levels in tongue, stomach and duodenum. Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway taste receptor activity membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009bne.1 uc009bne.2 
ENSMUST00000076576.7 Sult2a6 ENSMUST00000076576.7 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6 (from RefSeq NM_001081325.2) B2RVI8 ENSMUST00000076576.1 ENSMUST00000076576.2 ENSMUST00000076576.3 ENSMUST00000076576.4 ENSMUST00000076576.5 ENSMUST00000076576.6 Gm6957 NM_001081325 ST2A6_MOUSE Sult2a6 uc009fga.1 uc009fga.2 uc009fga.3 uc009fga.4 This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC147210.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of the hydroxyl group of hydroxysteroids and bile acids. Reaction=3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'- bisphosphate + an alkyl sulfate + H(+); Xref=Rhea:RHEA:22552, ChEBI:CHEBI:15378, ChEBI:CHEBI:30879, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:83414; EC=2.8.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22553; Evidence=; Reaction=3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate; Xref=Rhea:RHEA:10908, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:60007, ChEBI:CHEBI:60008; EC=2.8.2.14; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10909; Evidence=; Reaction=3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate; Xref=Rhea:RHEA:14013, ChEBI:CHEBI:15378, ChEBI:CHEBI:17179, ChEBI:CHEBI:58301, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343; EC=2.8.2.14; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14014; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+); Xref=Rhea:RHEA:51216, ChEBI:CHEBI:15378, ChEBI:CHEBI:28689, ChEBI:CHEBI:57905, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51217; Evidence=; Oligomer. Cytoplasm, cytosol Belongs to the sulfotransferase 1 family. alcohol sulfotransferase activity cytoplasm cytosol drug binding sulfotransferase activity biological_process transferase activity bile-salt sulfotransferase activity steroid sulfotransferase activity 3'-phosphoadenosine 5'-phosphosulfate binding uc009fga.1 uc009fga.2 uc009fga.3 uc009fga.4 
ENSMUST00000076592.4 Iho1 ENSMUST00000076592.4 interactor of HORMAD1 1, transcript variant 4 (from RefSeq NM_001411370.1) Ccdc36 ENSMUST00000076592.1 ENSMUST00000076592.2 ENSMUST00000076592.3 IHO1_MOUSE Iho1 NM_001411370 Q6PDM4 uc009rpl.1 uc009rpl.2 uc009rpl.3 uc009rpl.4 uc009rpl.5 Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:27723721). Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721). Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance (PubMed:27723721). Part of the MCD recombinosome complex, at least composed of IHO1, REC114 and MEI4 (PubMed:27723721, PubMed:30569039). Interacts with REC114 (PubMed:27723721). Interacts with MEI4 (PubMed:30569039). Interacts with HORMAD1 (PubMed:27723721). Interacts with ANKRD31 (PubMed:31000436). Chromosome Note=Specifically localizes to unsynapsed chromosomal regions during meiosis (PubMed:27723721). Appears on chromatin during preleptotene, when pre-meiotic replication occurs and axes have not yet developed (PubMed:27723721). Remains associated with unsynapsed axesn zygotene, when axes elongate and synapsis begins but disappears from synapsed axes (PubMed:27723721). Localization diverges in the two sexes beyond zygotene (PubMed:27723721). In spermatocytes, synapsis between the largely non-homologous X and Y chromosomes is mostly constrained to their short pseudoautosomal regions (PARs) (PubMed:27723721). At the zygotene-to-pachytene transition, high levels remain on unsynapsed sex chromosome axes but also on PARs (PubMed:27723721). However, by early pachytene disappears from both the synapsed and unsynapsed regions of sex chromosomes (PubMed:27723721). Reaccumulates on unsynapsed axes of sex chromosomes in mid-late pachytene and on desynapsing autosome axes in diplotene, but disappears from chromatin concomitant with axis disassembly after diplotene (PubMed:27723721). In oocytes, disappears from axes after all chromosomes synapsed and is undetectable on chromatin beyond zygotene (PubMed:27723721). Ovarian levels also dramatically decrease as oocytes progress to late prophase (PubMed:27723721). HORMAD1 is required for robust accumulation on chromatin and unsynapsed axes, suggesting that HORMAD1 recruits IHO1 to unsynapsed axes (PubMed:27723721). Detected in spermatocytes and testis (at protein level) (PubMed:27723721). Meiosis-specific. Mice develop normally without obvious somatic defects but males and females are sterile due to defects in homologous synapsis (PubMed:27723721). Oocytes are depleted in six-week-old females and spermatocytes in males undergo apoptosis at a stage equivalent to wild-type mid-pachytene (PubMed:27723721). Complete synapsis is never observed and incomplete synaptonemal complexes are detected in meiocytes equivalent to late-zygotene and pachytene (PubMed:27723721). Sequence=AAH58624.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; condensed nuclear chromosome protein binding chromosome DNA recombination synapsis spermatogenesis cell differentiation meiotic DNA double-strand break formation oogenesis meiotic cell cycle regulation of homologous chromosome segregation uc009rpl.1 uc009rpl.2 uc009rpl.3 uc009rpl.4 uc009rpl.5 
ENSMUST00000076599.8 Ap4b1 ENSMUST00000076599.8 adaptor-related protein complex AP-4, beta 1, transcript variant 2 (from RefSeq NM_001163552.1) AP4B1_MOUSE Ap4b1 B0V3P2 ENSMUST00000076599.1 ENSMUST00000076599.2 ENSMUST00000076599.3 ENSMUST00000076599.4 ENSMUST00000076599.5 ENSMUST00000076599.6 ENSMUST00000076599.7 NM_001163552 Q9WV76 uc008qtq.1 uc008qtq.2 uc008qtq.3 uc008qtq.4 Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (By similarity). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (PubMed:18341993). AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (By similarity). Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1). Interacts with TEPSIN; this interaction requires the presence of a functional AP-4 complex (By similarity). Interacts with GRIA2; probably indirect it mediates the somatodendritic localization of GRIA2 in neurons (PubMed:18341993). Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Mice lacking Ap4b1 are fertile, have no overt anatomical abnormalities and have normal life spans. They only show a significantly poorer rotorod performance than wild-type mice. No significant differences in body weight or grip power is observed compared to wild-type mice. The cerebella has normal foliation and a normal laminated cortical structure. Main neuronal types are present in the cerebella and the gross morphology of the soma and dendrites of Purkinje cells is normal. Belongs to the adaptor complexes large subunit family. protein binding Golgi apparatus trans-Golgi network cytosol protein targeting intracellular protein transport protein transport membrane vesicle-mediated transport extrinsic component of membrane membrane coat AP-4 adaptor complex clathrin adaptor complex clathrin binding uc008qtq.1 uc008qtq.2 uc008qtq.3 uc008qtq.4 
ENSMUST00000076605.9 Gnal ENSMUST00000076605.9 guanine nucleotide binding protein, alpha stimulating, olfactory type, transcript variant 1 (from RefSeq NM_010307.3) ENSMUST00000076605.1 ENSMUST00000076605.2 ENSMUST00000076605.3 ENSMUST00000076605.4 ENSMUST00000076605.5 ENSMUST00000076605.6 ENSMUST00000076605.7 ENSMUST00000076605.8 GNAL_MOUSE NM_010307 Q61020 Q61589 Q8CGK7 uc008flt.1 uc008flt.2 uc008flt.3 uc008flt.4 uc008flt.5 uc008flt.6 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters (By similarity). G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GAS2L2 (PubMed:23994616). Belongs to the G-alpha family. G(s) subfamily. nucleotide binding G-protein coupled receptor binding response to amphetamine GTPase activity GTP binding heterotrimeric G-protein complex signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity adenylate cyclase-activating dopamine receptor signaling pathway sensory perception of smell guanyl nucleotide binding response to caffeine G-protein beta/gamma-subunit complex binding metal ion binding uc008flt.1 uc008flt.2 uc008flt.3 uc008flt.4 uc008flt.5 uc008flt.6 
ENSMUST00000076615.6 Crtc1 ENSMUST00000076615.6 CREB regulated transcription coactivator 1, transcript variant 17 (from RefSeq NM_001404430.1) CRTC1_MOUSE Crtc1 ENSMUST00000076615.1 ENSMUST00000076615.2 ENSMUST00000076615.3 ENSMUST00000076615.4 ENSMUST00000076615.5 Kiaa0616 Mect1 NM_001404430 Q68ED7 Q6ZQ85 Torc1 uc009mae.1 uc009mae.2 uc009mae.3 Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 (By similarity). 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (By similarity). Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1 (By similarity). Interacts with 14-3-3 proteins, including YWHAE/14-3-3 epsilon (PubMed:28235073, PubMed:30611118). Interacts with calmodulin- dependent catalytic subunit PPP3CA/calcineurin A (PubMed:30611118). Cytoplasm cleus Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels (By similarity). Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain (PubMed:23699513). Highly expressed in specific regions of the brain including the cortex, hippocampus and striatum. Expressed in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain. Expression is highest during the day and reaches a nadir during the early subjective night. Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1. Belongs to the TORC family. Sequence=BAC97983.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane memory cAMP response element binding protein binding postsynaptic density nuclear body dendrite positive regulation of CREB transcription factor activity neuronal cell body entrainment of circadian clock by photoperiod synapse positive regulation of transcription from RNA polymerase II promoter rhythmic process protein homotetramerization energy homeostasis glutamatergic synapse postsynapse to nucleus signaling pathway positive regulation of dendrite development positive regulation of long-term synaptic potentiation negative regulation of membrane hyperpolarization uc009mae.1 uc009mae.2 uc009mae.3 
ENSMUST00000076617.7 Fbxw19 ENSMUST00000076617.7 F-box and WD-40 domain protein 19 (from RefSeq NM_177703.3) ENSMUST00000076617.1 ENSMUST00000076617.2 ENSMUST00000076617.3 ENSMUST00000076617.4 ENSMUST00000076617.5 ENSMUST00000076617.6 Fbxw19 NM_177703 Q8C2W8 Q8C2W8_MOUSE uc009rsk.1 uc009rsk.2 uc009rsk.3 molecular_function cellular_component biological_process uc009rsk.1 uc009rsk.2 uc009rsk.3 
ENSMUST00000076622.4 Stmnd1 ENSMUST00000076622.4 stathmin domain containing 1 (from RefSeq NM_001005422.1) ENSMUST00000076622.1 ENSMUST00000076622.2 ENSMUST00000076622.3 Gm1574 NM_001005422 Q6P3A1 STMD1_MOUSE uc007qhd.1 uc007qhd.2 cytoplasm microtubule depolymerization tubulin binding regulation of microtubule polymerization or depolymerization neuron projection development neuron projection regulation of cytoskeleton organization uc007qhd.1 uc007qhd.2 
ENSMUST00000076623.8 Arap2 ENSMUST00000076623.8 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 (from RefSeq NM_178407.3) Arap2 E9QP44 E9QP44_MOUSE ENSMUST00000076623.1 ENSMUST00000076623.2 ENSMUST00000076623.3 ENSMUST00000076623.4 ENSMUST00000076623.5 ENSMUST00000076623.6 ENSMUST00000076623.7 NM_178407 uc008xma.1 uc008xma.2 uc008xma.3 uc008xma.4 uc008xma.5 Cytoplasm GTPase activator activity phosphatidylinositol-3,4,5-trisphosphate binding signal transduction positive regulation of GTPase activity uc008xma.1 uc008xma.2 uc008xma.3 uc008xma.4 uc008xma.5 
ENSMUST00000076634.5 Esr2 ENSMUST00000076634.5 estrogen receptor 2 (beta), transcript variant 2 (from RefSeq NM_010157.3) A0A0R4J0Y6 A0A0R4J0Y6_MOUSE ENSMUST00000076634.1 ENSMUST00000076634.2 ENSMUST00000076634.3 ENSMUST00000076634.4 Esr2 NM_010157 uc007nxv.1 uc007nxv.2 uc007nxv.3 Nucleus Belongs to the nuclear hormone receptor family. NR3 subfamily. DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity steroid binding nucleus regulation of transcription, DNA-templated zinc ion binding estrogen receptor activity intracellular estrogen receptor signaling pathway sequence-specific DNA binding metal ion binding uc007nxv.1 uc007nxv.2 uc007nxv.3 
ENSMUST00000076638.7 1810009J06Rik ENSMUST00000076638.7 RIKEN cDNA 1810009J06 gene (from RefSeq NM_023707.3) 1810009J06Rik ENSMUST00000076638.1 ENSMUST00000076638.2 ENSMUST00000076638.3 ENSMUST00000076638.4 ENSMUST00000076638.5 ENSMUST00000076638.6 NM_023707 Q9CPN7 Q9CPN7_MOUSE trypsinogen uc009bnn.1 uc009bnn.2 uc009bnn.3 serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009bnn.1 uc009bnn.2 uc009bnn.3 
ENSMUST00000076648.8 Fcgbp ENSMUST00000076648.8 Fc fragment of IgG binding protein (from RefSeq NM_001122603.1) E9Q9C6 E9Q9C6_MOUSE ENSMUST00000076648.1 ENSMUST00000076648.2 ENSMUST00000076648.3 ENSMUST00000076648.4 ENSMUST00000076648.5 ENSMUST00000076648.6 ENSMUST00000076648.7 Fcgbp NM_001122603 uc009fxs.1 uc009fxs.2 uc009fxs.3 uc009fxs.4 biological_process extracellular matrix uc009fxs.1 uc009fxs.2 uc009fxs.3 uc009fxs.4 
ENSMUST00000076657.11 Ndufa3 ENSMUST00000076657.11 NADH:ubiquinone oxidoreductase subunit A3 (from RefSeq NM_025348.3) ENSMUST00000076657.1 ENSMUST00000076657.10 ENSMUST00000076657.2 ENSMUST00000076657.3 ENSMUST00000076657.4 ENSMUST00000076657.5 ENSMUST00000076657.6 ENSMUST00000076657.7 ENSMUST00000076657.8 ENSMUST00000076657.9 NDUA3_MOUSE NM_025348 Q0VBA7 Q9CQ91 uc009eve.1 uc009eve.2 uc009eve.3 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the complex I NDUFA3 subunit family. molecular_function mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I membrane integral component of membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc009eve.1 uc009eve.2 uc009eve.3 
ENSMUST00000076661.7 Etaa1 ENSMUST00000076661.7 Ewing tumor-associated antigen 1, transcript variant 1 (from RefSeq NM_026576.4) ENSMUST00000076661.1 ENSMUST00000076661.2 ENSMUST00000076661.3 ENSMUST00000076661.4 ENSMUST00000076661.5 ENSMUST00000076661.6 ETAA1_MOUSE Etaa1 NM_026576 Q5SVT3 Q8BZM6 Q8K332 Q9CS19 Q9D2Z9 uc007icf.1 uc007icf.2 uc007icf.3 uc007icf.4 Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets. Interacts (via RBM1 motif) with RPA1. Interacts (via RBM2 motif) with RPA2. Interacts (via the ATR-activation domain motif) with ATR. Nucleus Note=Localizes at sites of DNA damage following replication stress. Recruited to stalled replication forks via interaction with RPA1 and RPA2 subunits of the RPA complex. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5SVT3-1; Sequence=Displayed; Name=2; IsoId=Q5SVT3-2; Sequence=VSP_023538; Name=3; IsoId=Q5SVT3-3; Sequence=VSP_023537; The RBM1 (RPA1-binding, also named RPA70N-binding) motif mediates interaction with RPA1. The RBM2 (RPA2-binding, also named RPA32C-binding) motif mediates interaction with RPA2. The ATR-activation domain (AAD) motif is required to bind and activate ATR. Phosphorylated by ATR. It is uncertain whether Met-1 or Met-10 is the initiator. nucleus DNA repair cellular response to DNA damage stimulus replication fork processing protein serine/threonine kinase activator activity nuclear replication fork positive regulation of protein serine/threonine kinase activity regulation of DNA damage checkpoint uc007icf.1 uc007icf.2 uc007icf.3 uc007icf.4 
ENSMUST00000076667.3 0610039K10Rik ENSMUST00000076667.3 0610039K10Rik (from geneSymbol) AK002842 ENSMUST00000076667.1 ENSMUST00000076667.2 uc012civ.1 uc012civ.2 uc012civ.3 uc012civ.1 uc012civ.2 uc012civ.3 
ENSMUST00000076670.3 Plppr1 ENSMUST00000076670.3 phospholipid phosphatase related 1 (from RefSeq NM_178756.4) ENSMUST00000076670.1 ENSMUST00000076670.2 Kiaa4247 Lppr1 NM_178756 PLPR1_MOUSE Plppr1 Prg3 Q4V9R3 Q5DTF2 Q8BFZ2 Q8BID2 Q8BIQ1 uc008svp.1 uc008svp.2 uc008svp.3 May play a role in neurite outgrowth and neurogenesis. Cell membrane ; Multi-pass membrane protein Cell projection, neuron projection Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BFZ2-1; Sequence=Displayed; Name=2; IsoId=Q8BFZ2-2; Sequence=VSP_031009; Belongs to the PA-phosphatase related phosphoesterase family. Has no 2-lysophosphatidate/LPA phosphatase activity. This is supported by the fact that the phosphatase sequence motifs as well as the His residue acting as a nucleophile in active phosphatases of the PA-phosphatase related phosphoesterase family are not conserved. Sequence=BAD90332.1; Type=Erroneous initiation; Evidence=; nucleoplasm integral component of plasma membrane phospholipid metabolic process nervous system development phosphatidate phosphatase activity membrane integral component of membrane phosphatase activity lipid phosphatase activity phospholipid dephosphorylation uc008svp.1 uc008svp.2 uc008svp.3 
ENSMUST00000076671.4 Cldn34b2 ENSMUST00000076671.4 claudin 34B2, transcript variant 2 (from RefSeq NM_028511.1) 1700042B14Rik Cldn34b2 ENSMUST00000076671.1 ENSMUST00000076671.2 ENSMUST00000076671.3 NM_028511 Q9D9N2 Q9D9N2_MOUSE uc033jvd.1 uc033jvd.2 uc033jvd.3 Cell junction, tight junction Belongs to the claudin family. molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc033jvd.1 uc033jvd.2 uc033jvd.3 
ENSMUST00000076674.4 Grin3a ENSMUST00000076674.4 glutamate receptor ionotropic, NMDA3A, transcript variant 2 (from RefSeq NM_001033351.2) A2AIR4 A2AIR5 ENSMUST00000076674.1 ENSMUST00000076674.2 ENSMUST00000076674.3 Kiaa1973 NMD3A_MOUSE NM_001033351 Q69Z52 uc012ded.1 uc012ded.2 uc012ded.3 uc012ded.4 NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth (By similarity). By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses (PubMed:24297929). May also play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (By similarity). Interacts (via C-terminus) with GIT1, but not with GRIA1/GluA1, nor with synaptophysin/SYP; this interaction competes with GIT1 interaction with ARHGEF7/beta-PIX (PubMed:24297929). Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane Postsynaptic density Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AIR5-1; Sequence=Displayed; Name=2; IsoId=A2AIR5-2; Sequence=VSP_061048; Expressed in the brain (at protein level). Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily. ionotropic glutamate receptor activity NMDA glutamate receptor activity ion channel activity calcium channel activity protein binding plasma membrane ion transport calcium ion transport glutamate receptor activity ligand-gated ion channel activity membrane integral component of membrane dendrite development glycine binding NMDA selective glutamate receptor complex cell junction ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic signaling receptor activity neurotransmitter binding identical protein binding neuron projection neuronal cell body synapse postsynaptic membrane response to ethanol rhythmic process modulation of synaptic transmission protein phosphatase 2A binding regulation of postsynaptic membrane potential prepulse inhibition calcium ion transmembrane transport postsynaptic density membrane glutamatergic synapse integral component of postsynaptic density membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential regulation of synaptic vesicle exocytosis uc012ded.1 uc012ded.2 uc012ded.3 uc012ded.4 
ENSMUST00000076694.13 Slc25a3 ENSMUST00000076694.13 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 (from RefSeq NM_133668.4) ENSMUST00000076694.1 ENSMUST00000076694.10 ENSMUST00000076694.11 ENSMUST00000076694.12 ENSMUST00000076694.2 ENSMUST00000076694.3 ENSMUST00000076694.4 ENSMUST00000076694.5 ENSMUST00000076694.6 ENSMUST00000076694.7 ENSMUST00000076694.8 ENSMUST00000076694.9 NM_133668 Q542V7 Q8VEM8 S25A3_MOUSE Slc25a3 uc007gtn.1 uc007gtn.2 uc007gtn.3 Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity). Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity). Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (PubMed:29237729). May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity). Reaction=H(+)(in) + phosphate(in) = H(+)(out) + phosphate(out); Xref=Rhea:RHEA:29939, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29941; Evidence=; Interacts with PPIF; the interaction is impaired by CsA. Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. inorganic phosphate transmembrane transporter activity mitochondrion mitochondrial inner membrane symporter activity membrane integral component of membrane integral component of mitochondrial inner membrane phosphate ion transmembrane transport myelin sheath macromolecular complex binding uc007gtn.1 uc007gtn.2 uc007gtn.3 
ENSMUST00000076700.11 Ikzf1 ENSMUST00000076700.11 IKAROS family zinc finger 1, transcript variant 63 (from RefSeq NM_001404554.1) ENSMUST00000076700.1 ENSMUST00000076700.10 ENSMUST00000076700.2 ENSMUST00000076700.3 ENSMUST00000076700.4 ENSMUST00000076700.5 ENSMUST00000076700.6 ENSMUST00000076700.7 ENSMUST00000076700.8 ENSMUST00000076700.9 G5E8H3 G5E8H3_MOUSE Ikzf1 NM_001404554 uc007iak.1 uc007iak.2 uc007iak.3 uc007iak.4 nucleic acid binding DNA binding nucleus nucleoplasm protein domain specific binding lymphocyte differentiation erythrocyte differentiation nuclear pericentric heterochromatin macromolecular complex protein heterooligomerization uc007iak.1 uc007iak.2 uc007iak.3 uc007iak.4 
ENSMUST00000076713.6 Ccn6 ENSMUST00000076713.6 cellular communication network factor 6 (from RefSeq NM_001127376.1) CCN6_MOUSE Ccn6 D3Z5L9 ENSMUST00000076713.1 ENSMUST00000076713.2 ENSMUST00000076713.3 ENSMUST00000076713.4 ENSMUST00000076713.5 NM_001127376 Wisp3 uc011xcu.1 uc011xcu.2 uc011xcu.3 Plays a role in mitochondrial electron transport and mitochondrial respiration. Secreted Mitochondrion Note=Associated with membranes. Deficient mice are viable and fertile with no obvious abnormalities in size, weight, skeletal development, ossification, or the occurrence of joint disease. Belongs to the CCN family. integrin binding insulin-like growth factor binding extracellular region extracellular space mitochondrion endoplasmic reticulum cell adhesion signal transduction growth factor activity heparin binding negative regulation of cell proliferation negative regulation of angiogenesis extracellular matrix regulation of mitochondrial membrane potential negative regulation of cell death regulation of reactive oxygen species biosynthetic process uc011xcu.1 uc011xcu.2 uc011xcu.3 
ENSMUST00000076730.8 Gm1123 ENSMUST00000076730.8 predicted gene 1123 (from RefSeq NM_001080776.1) CLSP ENSMUST00000076730.1 ENSMUST00000076730.2 ENSMUST00000076730.3 ENSMUST00000076730.4 ENSMUST00000076730.5 ENSMUST00000076730.6 ENSMUST00000076730.7 Gm1123 NM_001080776 Q1RME4 Q1RME4_MOUSE uc009rdu.1 uc009rdu.2 uc009rdu.3 Basolateral cell membrane ; Single-pass type I membrane protein Cell junction, adherens junction Cell junction, tight junction Lateral cell membrane ; Single-pass type I membrane protein molecular_function uc009rdu.1 uc009rdu.2 uc009rdu.3 
ENSMUST00000076734.8 Scaf8 ENSMUST00000076734.8 SR-related CTD-associated factor 8 (from RefSeq NM_134123.3) ENSMUST00000076734.1 ENSMUST00000076734.2 ENSMUST00000076734.3 ENSMUST00000076734.4 ENSMUST00000076734.5 ENSMUST00000076734.6 ENSMUST00000076734.7 Kiaa1116 NM_134123 Q3TTX6 Q5U5V8 Q6DID3 Q80TJ3 Q8C037 Rbm16 SCAF8_MOUSE Scaf8 uc008aej.1 uc008aej.2 uc008aej.3 uc008aej.4 Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation. Interacts with POLR2A; via C-terminal heptapeptide repeat domain (CTD) phosphorylated at 'Ser-2' and 'Ser-5' (PubMed:9528809). Identified in a complex with CDC5L and other spliceosomal proteins (By similarity). Nucleus Nucleus matrix Note=Detected in granular nuclear foci which correspond to sites of active transcription. Sequence=BAC65733.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA polymerase II core binding nucleic acid binding RNA binding mRNA binding nucleus nucleoplasm cytoplasm mRNA cleavage factor complex transcription from RNA polymerase II promoter termination of RNA polymerase II transcription mRNA polyadenylation mRNA processing nuclear matrix protein domain specific binding positive regulation of DNA-templated transcription, elongation RNA polymerase core enzyme binding RNA polymerase binding RNA polymerase II C-terminal domain phosphoserine binding negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled uc008aej.1 uc008aej.2 uc008aej.3 uc008aej.4 
ENSMUST00000076737.7 Dsg1b ENSMUST00000076737.7 desmoglein 1 beta (from RefSeq NM_181682.2) DSG1B_MOUSE Dsg5 ENSMUST00000076737.1 ENSMUST00000076737.2 ENSMUST00000076737.3 ENSMUST00000076737.4 ENSMUST00000076737.5 ENSMUST00000076737.6 NM_181682 Q7TQ60 Q7TSF1 uc008eem.1 uc008eem.2 uc008eem.3 uc008eem.4 This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036986.1, AY192158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Cell membrane ; Single-pass type I membrane protein Cell junction, desmosome Cytoplasm Nucleus Expressed in epidermis. Expressed in embryo at 17 dpc. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. calcium ion binding plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cytoplasmic side of plasma membrane membrane integral component of membrane apical plasma membrane lateral plasma membrane cell junction desmosome gamma-catenin binding metal ion binding cell-cell adhesion uc008eem.1 uc008eem.2 uc008eem.3 uc008eem.4 
ENSMUST00000076754.3 Defa21 ENSMUST00000076754.3 defensin, alpha, 21 (from RefSeq NM_183253.3) DFA21_MOUSE Defcr21 ENSMUST00000076754.1 ENSMUST00000076754.2 NM_183253 Q8C1P2 uc009lbj.1 uc009lbj.2 uc009lbj.3 uc009lbj.4 May have microbicidal activities. Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc009lbj.1 uc009lbj.2 uc009lbj.3 uc009lbj.4 
ENSMUST00000076756.3 Tas2r106 ENSMUST00000076756.3 taste receptor, type 2, member 106 (from RefSeq NM_207016.1) ENSMUST00000076756.1 ENSMUST00000076756.2 NM_207016 Q3B817 Q7M724 T2r44 TR106_MOUSE Tas2r106 uc009eix.1 uc009eix.2 Putative taste receptor which may play a role in the perception of bitterness. Membrane ; Multi-pass membrane protein Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane response to stimulus sensory perception of taste uc009eix.1 uc009eix.2 
ENSMUST00000076786.3 Defb35 ENSMUST00000076786.3 defensin beta 35 (from RefSeq NM_139224.1) DFB35_MOUSE ENSMUST00000076786.1 ENSMUST00000076786.2 NM_139224 Q8R2I3 uc009lcf.1 uc009lcf.2 Has antibacterial activity. Secreted Expressed in testis, epididymis (caput, corpus and cauda), kidney and neonatal and adult brain. Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium innate immune response uc009lcf.1 uc009lcf.2 
ENSMUST00000076803.12 Atg13 ENSMUST00000076803.12 autophagy related 13, transcript variant 7 (from RefSeq NM_145528.3) A2AH18 ATG13_MOUSE D2Ertd391e ENSMUST00000076803.1 ENSMUST00000076803.10 ENSMUST00000076803.11 ENSMUST00000076803.2 ENSMUST00000076803.3 ENSMUST00000076803.4 ENSMUST00000076803.5 ENSMUST00000076803.6 ENSMUST00000076803.7 ENSMUST00000076803.8 ENSMUST00000076803.9 Kiaa0652 NM_145528 Q80TU9 Q91YI1 uc008kwn.1 uc008kwn.2 uc008kwn.3 uc008kwn.4 Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. Part of a complex consisting of ATG13, ULK1 and RB1CC1 (PubMed:19258318, PubMed:19211835). Interacts with ATG101 (By similarity). Interacts with ULK1 (via C-terminus); this interaction is increased in the absence of TMEM39A (By similarity). Interacts with ULK2 (via C-terminus) (By similarity). Interacts (via the LIR motif) with GABARAP, GABARAPL and GABARAPL2 (By similarity). Interacts (via the LIR motif) with MAP1LC3A, MAP1LC3B and MAP1LC3C (By similarity). Interacts with TAB2 and TAB3 (By similarity). Interacts with C9orf72 (By similarity). Interacts with RB1CC1; this interaction is increased in the absence of TMEM39A (By similarity). Q91YI1; Q9BSB4: ATG101; Xeno; NbExp=2; IntAct=EBI-8391007, EBI-2946739; Cytoplasm, cytosol eautophagosomal structure Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91YI1-1; Sequence=Displayed; Name=2; IsoId=Q91YI1-2; Sequence=VSP_034922; The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins GABARAP, GABARAPL, GABARAPL2, and MAP1LC3A. Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-354 is required for efficient clearance of depolarized mitochondria. Belongs to the ATG13 family. Metazoan subfamily. Sequence=BAC65621.3; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence=; autophagosome assembly pre-autophagosomal structure mitophagy macromitophagy protein binding cytoplasm mitochondrion cytosol autophagy macroautophagy protein kinase regulator activity extrinsic component of membrane protein kinase binding activation of protein kinase activity protein localization to pre-autophagosomal structure piecemeal microautophagy of nucleus response to mitochondrial depolarisation ATG1/ULK1 kinase complex uc008kwn.1 uc008kwn.2 uc008kwn.3 uc008kwn.4 
ENSMUST00000076807.7 Pcdhgc3 ENSMUST00000076807.7 protocadherin gamma subfamily C, 3 (from RefSeq NM_033581.3) ENSMUST00000076807.1 ENSMUST00000076807.2 ENSMUST00000076807.3 ENSMUST00000076807.4 ENSMUST00000076807.5 ENSMUST00000076807.6 NM_033581 Pcdhgc3 Q91XX1 Q91XX1_MOUSE uc008ere.1 uc008ere.2 uc008ere.3 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding plasma membrane integral component of plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules metal ion binding synapse organization uc008ere.1 uc008ere.2 uc008ere.3 
ENSMUST00000076810.12 Kalrn ENSMUST00000076810.12 kalirin, RhoGEF kinase, transcript variant 1 (from RefSeq NM_177357.3) A2CG49 A2CG50 A2CG51 A2CG52 A2CG53 B2RXR5 D3Z559 ENSMUST00000076810.1 ENSMUST00000076810.10 ENSMUST00000076810.11 ENSMUST00000076810.2 ENSMUST00000076810.3 ENSMUST00000076810.4 ENSMUST00000076810.5 ENSMUST00000076810.6 ENSMUST00000076810.7 ENSMUST00000076810.8 ENSMUST00000076810.9 KALRN_MOUSE Kalrn NM_177357 Q3TXY8 Q3TYL1 Q3UTA5 Q8BTT9 Q8C4Q2 Q9CVA9 uc289ehh.1 uc289ehh.2 Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with the C-terminal of peptidylglycine alpha- amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1). Interacts with FASLG (By similarity). Cytoplasm toplasm, cytoskeleton Event=Alternative splicing, Alternative initiation; Named isoforms=10; Name=1; Synonyms=Kalirin-12A ; IsoId=A2CG49-1; Sequence=Displayed; Name=2; Synonyms=Kalirin-9A ; IsoId=A2CG49-2; Sequence=VSP_052576, VSP_052579; Name=3 ; IsoId=A2CG49-3; Sequence=VSP_052562; Name=4 ; IsoId=A2CG49-4; Sequence=VSP_052563, VSP_052570, VSP_052571, VSP_052573, VSP_052577, VSP_052578; Name=5 ; IsoId=A2CG49-5; Sequence=VSP_052564, VSP_052567, VSP_052568, VSP_052569; Name=6 ; IsoId=A2CG49-6; Sequence=VSP_052563, VSP_052570, VSP_052573, VSP_052574, VSP_052575; Name=7 ; IsoId=A2CG49-7; Sequence=VSP_052565, VSP_052572; Name=8 ; IsoId=A2CG49-8; Sequence=VSP_052566, VSP_052567, VSP_052568, VSP_052569; Name=9 ; Synonyms=Kalirin-7c ; IsoId=A2CG49-9; Sequence=VSP_052566, VSP_052568, VSP_052569; Name=10; Synonyms=Delta Kalirin-7 ; IsoId=A2CG49-10; Sequence=VSP_052564, VSP_052568, VSP_052569; The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity). Autophosphorylated. [Isoform 1]: Produced by alternative splicing. [Isoform 2]: Produced by alternative splicing. [Isoform 3]: Produced by alternative splicing. [Isoform 4]: Produced by alternative splicing. [Isoform 5]: Produced by alternative initiation at Met- 624 of isoform 1. Inferred by similarity. [Isoform 6]: Produced by alternative splicing. [Isoform 7]: Produced by alternative splicing. [Isoform 8]: Produced by alternative splicing. [Isoform 9]: Produced by alternative splicing. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding ATP binding nucleoplasm cytoplasm cytosol cytoskeleton protein phosphorylation nervous system development axonogenesis neuromuscular junction development lactation memory adult locomotory behavior postsynaptic density kinase activity phosphorylation transferase activity enzyme binding regulation of Rho protein signal transduction social behavior intracellular signal transduction maternal behavior neuron projection neuronal cell body positive regulation of GTPase activity metal ion binding habituation perinuclear region of cytoplasm regulation of dendrite development negative regulation of growth hormone secretion maternal process involved in parturition positive regulation of dendritic spine morphogenesis presynapse modification of postsynaptic actin cytoskeleton glutamatergic synapse NMDA selective glutamate receptor signaling pathway neurotransmitter receptor localization to postsynaptic specialization membrane regulation of modification of postsynaptic actin cytoskeleton uc289ehh.1 uc289ehh.2 
ENSMUST00000076813.8 Iah1 ENSMUST00000076813.8 isoamyl acetate-hydrolyzing esterase 1 homolog (from RefSeq NM_026347.3) ENSMUST00000076813.1 ENSMUST00000076813.2 ENSMUST00000076813.3 ENSMUST00000076813.4 ENSMUST00000076813.5 ENSMUST00000076813.6 ENSMUST00000076813.7 IAH1_MOUSE NM_026347 Q9DB29 uc007ndt.1 uc007ndt.2 uc007ndt.3 Probable lipase. Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily. lipid metabolic process biological_process lipid catabolic process hydrolase activity uc007ndt.1 uc007ndt.2 uc007ndt.3 
ENSMUST00000076831.7 Cdc42ep5 ENSMUST00000076831.7 CDC42 effector protein 5 (from RefSeq NM_021454.4) BORG3_MOUSE Borg3 Cep5 ENSMUST00000076831.1 ENSMUST00000076831.2 ENSMUST00000076831.3 ENSMUST00000076831.4 ENSMUST00000076831.5 ENSMUST00000076831.6 NM_021454 Q3SYK1 Q9QZT9 Q9Z0X0 uc009exe.1 uc009exe.2 uc009exe.3 uc009exe.4 Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42. Interacts with CDC42 in a GTP-dependent manner, and with SEPT7. Endomembrane system ; Peripheral membrane protein Cytoplasm, cytoskeleton Highly expressed in the skeletal muscle. The CRIB domain mediates interaction with CDC42. Belongs to the BORG/CEP family. protein binding cytoplasm cytoskeleton plasma membrane JNK cascade Rho protein signal transduction regulation of cell shape endomembrane system membrane GTP-Rho binding positive regulation of actin filament polymerization positive regulation of pseudopodium assembly uc009exe.1 uc009exe.2 uc009exe.3 uc009exe.4 
ENSMUST00000076840.12 Efna5 ENSMUST00000076840.12 ephrin A5, transcript variant 1 (from RefSeq NM_207654.3) EFNA5_MOUSE ENSMUST00000076840.1 ENSMUST00000076840.10 ENSMUST00000076840.11 ENSMUST00000076840.2 ENSMUST00000076840.3 ENSMUST00000076840.4 ENSMUST00000076840.5 ENSMUST00000076840.6 ENSMUST00000076840.7 ENSMUST00000076840.8 ENSMUST00000076840.9 Epl7 Eplg7 Lerk7 NM_207654 O08543 O08544 uc008dfg.1 uc008dfg.2 uc008dfg.3 uc008dfg.4 Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. Binds to the receptor tyrosine kinases EPHA2, EPHA3 and EPHB1. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function (By similarity). Binds to EPHB2. Interacts with EPHA8; activates EPHA8. Cell membrane ; Lipid-anchor, GPI- anchor Membrane, caveola ; Lipid-anchor, GPI-anchor Note=Compartmentalized in discrete caveolae- like membrane microdomains. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=O08543-1; Sequence=Displayed; Name=Short; IsoId=O08543-2; Sequence=VSP_001449; Expressed in myogenic progenitor cells. In myogenic progenitor cells, highly expressed at 11.5 dpc and ceases its expression at the late fetal stage (17.5 dpc). Mice display cataract an opacification of the lens. Belongs to the ephrin family. neurotrophin TRKB receptor binding protein binding basement membrane plasma membrane caveola adherens junction multicellular organism development nervous system development axon guidance brain development membrane regulation of cell-cell adhesion regulation of cell morphogenesis cell differentiation anchored component of membrane retinal ganglion cell axon guidance anchored component of external side of plasma membrane regulation of actin cytoskeleton organization regulation of GTPase activity chemorepellent activity ephrin receptor binding ephrin receptor signaling pathway collateral sprouting positive regulation of collateral sprouting positive regulation of peptidyl-tyrosine phosphorylation negative chemotaxis regulation of focal adhesion assembly positive regulation of synapse assembly regulation of insulin secretion involved in cellular response to glucose stimulus regulation of microtubule cytoskeleton organization cellular response to follicle-stimulating hormone stimulus cell periphery GABA-ergic synapse synaptic membrane adhesion negative regulation of substrate adhesion-dependent cell spreading cellular response to forskolin uc008dfg.1 uc008dfg.2 uc008dfg.3 uc008dfg.4 
ENSMUST00000076846.11 Il34 ENSMUST00000076846.11 interleukin 34, transcript variant 1 (from RefSeq NM_001135100.2) B2ZC71 B2ZC72 ENSMUST00000076846.1 ENSMUST00000076846.10 ENSMUST00000076846.2 ENSMUST00000076846.3 ENSMUST00000076846.4 ENSMUST00000076846.5 ENSMUST00000076846.6 ENSMUST00000076846.7 ENSMUST00000076846.8 ENSMUST00000076846.9 IL34_MOUSE NM_001135100 Q8R1R4 Q9D8F2 uc009nla.1 uc009nla.2 uc009nla.3 uc009nla.4 uc009nla.5 Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity). Homodimer. Interacts with CSF1R (By similarity). Secreted Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R1R4-1; Sequence=Displayed; Name=2; IsoId=Q8R1R4-2; Sequence=VSP_026632; Name=3; IsoId=Q8R1R4-3; Sequence=VSP_035080; Belongs to the IL-34 family. positive regulation of protein phosphorylation immune system process cytokine activity macrophage colony-stimulating factor receptor binding extracellular region extracellular space inflammatory response signal transduction growth factor activity positive regulation of cell proliferation positive regulation of gene expression identical protein binding innate immune response positive regulation of macrophage differentiation positive regulation of monocyte differentiation positive regulation of oligodendrocyte differentiation microglial cell proliferation uc009nla.1 uc009nla.2 uc009nla.3 uc009nla.4 uc009nla.5 
ENSMUST00000076850.2 Or1j16 ENSMUST00000076850.2 olfactory receptor family 1 subfamily J member 16 (from RefSeq NM_146945.1) ENSMUST00000076850.1 NM_146945 Olfr345 Or1j16 Q8VGK4 Q8VGK4_MOUSE uc008jlt.1 uc008jlt.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC148219.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008jlt.1 uc008jlt.2 
ENSMUST00000076859.12 Plk3 ENSMUST00000076859.12 polo like kinase 3, transcript variant 1 (from RefSeq NM_013807.3) ENSMUST00000076859.1 ENSMUST00000076859.10 ENSMUST00000076859.11 ENSMUST00000076859.2 ENSMUST00000076859.3 ENSMUST00000076859.4 ENSMUST00000076859.5 ENSMUST00000076859.6 ENSMUST00000076859.7 ENSMUST00000076859.8 ENSMUST00000076859.9 NM_013807 Plk3 Q6P571 Q6P571_MOUSE uc008uib.1 uc008uib.2 uc008uib.3 This gene encodes a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal catalytic domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases have primarily been implicated in cell cycle regulation. In mouse, this protein that has been reported to localize to the nucleolus during interphase but is undetectable during mitosis, following nucleolus dissociation during prophase. The protein relocalizes to the nucleolus just prior to cytokinesis and peak levels are detected during G1 of interphase. This gene has been implicated in regulation of entry into S phase, with RNAi-induced depletion resulting in failure to re-enter the cell cycle. Mice deficient for this gene exhibit increased weight and tumor development at advanced age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.21; Evidence=; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter nucleotide binding response to reactive oxygen species p53 binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleolus cytoplasm Golgi stack centrosome protein phosphorylation response to osmotic stress cellular response to DNA damage stimulus response to radiation kinase activity phosphorylation transferase activity dendrite cytoplasmic microtubule organization regulation of cytokinesis neuronal cell body negative regulation of apoptotic process regulation of cell division Golgi disassembly positive regulation of intracellular protein transport positive regulation of chaperone-mediated autophagy positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia uc008uib.1 uc008uib.2 uc008uib.3 
ENSMUST00000076894.11 Cop1 ENSMUST00000076894.11 COP1, E3 ubiquitin ligase, transcript variant 1 (from RefSeq NM_011931.4) COP1_MOUSE Cop1 ENSMUST00000076894.1 ENSMUST00000076894.10 ENSMUST00000076894.2 ENSMUST00000076894.3 ENSMUST00000076894.4 ENSMUST00000076894.5 ENSMUST00000076894.6 ENSMUST00000076894.7 ENSMUST00000076894.8 ENSMUST00000076894.9 NM_011931 Q9R1A8 RNF200 Rfwd2 uc007ddz.1 uc007ddz.2 uc007ddz.3 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; TRIB1 competes with substrates for RFWD2 binding. Protein modification; protein ubiquitination. Homodimer. Homodimerization is mediated by the coiled coil domain. Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. Isoform 2 does not interact with CUL4A but still binds to RBX1, suggesting that the interaction may be mediated by another cullin protein. Isoform 1 and isoform 2 interact with CUL5 but not with CUL1, CUL2 not CUL3. Interacts with bZIP transcription factors JUN, JUNB and JUND but not with FOS, ATF2 nor XBP1. Interacts with p53 (TP53). Interacts with COPS6; this interaction stabilizes RFWD2 through reducing its auto- ubiquitination and decelerating its turnover rate. Interacts with SFN; this interaction leads to SFN degradation. Interacts with p53/TP53 and MTA1. Interacts with TRIB1 (via C-terminus) and TRIB2. Q9R1A8; Q3U182: Crtc2; NbExp=3; IntAct=EBI-15656898, EBI-8018890; Nucleus speckle Cytoplasm Note=In the nucleus, it forms nuclear speckles. The RING finger domain, in addition to its role in ubiquitination, functions as a structural scaffold to bring two clusters of positive-charged residues within spatial proximity to mimic a bipartite nuclear localization signal (NLS). The WD40 domain (386-731) is necessary and sufficient for TRIB1 binding. Belongs to the COP1 family. Golgi membrane protein binding nucleus cytoplasm response to ionizing radiation protein ubiquitination nuclear speck transferase activity Cul4A-RING E3 ubiquitin ligase complex positive regulation of proteasomal ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity uc007ddz.1 uc007ddz.2 uc007ddz.3 
ENSMUST00000076903.3 Or8g28 ENSMUST00000076903.3 olfactory receptor family 8 subfamily G member 28 (from RefSeq NM_146506.1) ENSMUST00000076903.1 ENSMUST00000076903.2 NM_146506 Olfr945 Or8g28 Q9EQB5 Q9EQB5_MOUSE uc292gaq.1 uc292gaq.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC128004.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gaq.1 uc292gaq.2 
ENSMUST00000076906.2 Krtap6-1 ENSMUST00000076906.2 keratin associated protein 6-1 (from RefSeq NM_010672.3) 1110025L11Rik ENSMUST00000076906.1 Gm10228 Krtap6-1 NM_010672 O09048 O09048_MOUSE uc007zvo.1 uc007zvo.2 Belongs to the KRTAP type 6 family. molecular_function cellular_component intermediate filament biological_process keratinization uc007zvo.1 uc007zvo.2 
ENSMUST00000076921.7 Arl16 ENSMUST00000076921.7 ADP-ribosylation factor-like 16 (from RefSeq NM_197995.2) Arl16 B1ATY8 B1ATY8_MOUSE ENSMUST00000076921.1 ENSMUST00000076921.2 ENSMUST00000076921.3 ENSMUST00000076921.4 ENSMUST00000076921.5 ENSMUST00000076921.6 NM_197995 uc007msw.1 uc007msw.2 uc007msw.3 nucleotide binding molecular_function GTP binding cellular_component biological_process uc007msw.1 uc007msw.2 uc007msw.3 
ENSMUST00000076922.6 Trim30a ENSMUST00000076922.6 tripartite motif-containing 30A, transcript variant 1 (from RefSeq NM_009099.2) ENSMUST00000076922.1 ENSMUST00000076922.2 ENSMUST00000076922.3 ENSMUST00000076922.4 ENSMUST00000076922.5 NM_009099 P15533 Q3UV85 Q3UZ29 Q99K55 Q99PQ7 Q99PQ8 Q99PQ9 Rpt-1 Rpt1 TR30A_MOUSE Trim30 uc009iwh.1 uc009iwh.2 uc009iwh.3 Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses. Homomultimer. Interacts with NR2C2/TAK1, TAB2 and TAB3. Does not interact with NLRP3, NLRC4 or TAB1. Cytoplasm. Nucleus. Event=Alternative splicing; Named isoforms=2; Name=Alpha; IsoId=P15533-1; Sequence=Displayed; Name=Beta; IsoId=P15533-2; Sequence=VSP_005762, VSP_005763; Highly expressed in spleen and lymph nodes (at protein level). By the TLR ligands lipopolysaccharide, CpG dinucleotide and polyinosinic-polycytidylic acid. Sequence=AAA40073.1; Type=Frameshift; Evidence=; Sequence=AAG53470.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; DNA binding ubiquitin-protein transferase activity nucleus cytoplasm autophagy zinc ion binding response to bacterium negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway innate immune response positive regulation of protein catabolic process positive regulation of viral entry into host cell metal ion binding defense response to virus protein autoubiquitination negative regulation of NLRP3 inflammasome complex assembly negative regulation of reactive oxygen species metabolic process uc009iwh.1 uc009iwh.2 uc009iwh.3 
ENSMUST00000076941.12 Ttf2 ENSMUST00000076941.12 transcription termination factor, RNA polymerase II (from RefSeq NM_001013026.2) ENSMUST00000076941.1 ENSMUST00000076941.10 ENSMUST00000076941.11 ENSMUST00000076941.2 ENSMUST00000076941.3 ENSMUST00000076941.4 ENSMUST00000076941.5 ENSMUST00000076941.6 ENSMUST00000076941.7 ENSMUST00000076941.8 ENSMUST00000076941.9 NM_001013026 Q4V9Y7 Q5M924 Q5NC05 TTF2_MOUSE uc008qrb.1 uc008qrb.2 uc008qrb.3 DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing (By similarity). Interacts with CDC5L. Part of the spliceosome (By similarity). Cytoplasm Nucleus Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis (By similarity). Belongs to the SNF2/RAD54 helicase family. nucleotide binding DNA binding helicase activity ATP binding nucleus spliceosomal complex cytoplasm cytosol DNA-templated transcription, termination mRNA processing biological_process zinc ion binding RNA splicing hydrolase activity uc008qrb.1 uc008qrb.2 uc008qrb.3 
ENSMUST00000076949.13 Gpn1 ENSMUST00000076949.13 GPN-loop GTPase 1 (from RefSeq NM_133756.6) ENSMUST00000076949.1 ENSMUST00000076949.10 ENSMUST00000076949.11 ENSMUST00000076949.12 ENSMUST00000076949.2 ENSMUST00000076949.3 ENSMUST00000076949.4 ENSMUST00000076949.5 ENSMUST00000076949.6 ENSMUST00000076949.7 ENSMUST00000076949.8 ENSMUST00000076949.9 GPN1_MOUSE Gpn1 Mbdin NM_133756 Q8VCE2 Xab1 uc008wyi.1 uc008wyi.2 uc008wyi.3 Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA. Heterodimer with GPN3. Binds to RNA polymerase II (RNAPII). Interacts directly with RNAPII subunits RPB4 and RPB7 and the CTD of RPB1. Interacts with XPA. Cytoplasm Nucleus Note=Shuttles between the nucleus and the cytoplasm. Belongs to the GPN-loop GTPase family. nucleotide binding GTPase activity GTP binding nucleus nucleoplasm cytoplasm mitochondrion cytosol hydrolase activity uc008wyi.1 uc008wyi.2 uc008wyi.3 
ENSMUST00000076957.7 Zdhhc8 ENSMUST00000076957.7 zinc finger, DHHC domain containing 8, transcript variant 1 (from RefSeq NM_172151.4) ENSMUST00000076957.1 ENSMUST00000076957.2 ENSMUST00000076957.3 ENSMUST00000076957.4 ENSMUST00000076957.5 ENSMUST00000076957.6 NM_172151 Q5Y5T5 Q7TNF7 ZDHC8_MOUSE Zdhhc8 uc007ymx.1 uc007ymx.2 Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes. Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (By similarity). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (By similarity). Could also play a role in glutamatergic transmission (PubMed:15184899). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Golgi apparatus membrane ; Multi-pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Expressed in brain cortex and hippocampus. The DHHC domain is required for palmitoyltransferase activity. Mice have normal brain morphology, but female have strong locomotor deficits in open field, due to a greater fear of new environments. Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. protein binding mitochondrion Golgi apparatus locomotory behavior membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups protein palmitoylation protein-cysteine S-palmitoyltransferase activity cytoplasmic vesicle membrane cytoplasmic vesicle perinuclear region of cytoplasm uc007ymx.1 uc007ymx.2 
ENSMUST00000076961.9 Rabac1 ENSMUST00000076961.9 Rab acceptor 1 (prenylated) (from RefSeq NM_010261.2) ENSMUST00000076961.1 ENSMUST00000076961.2 ENSMUST00000076961.3 ENSMUST00000076961.4 ENSMUST00000076961.5 ENSMUST00000076961.6 ENSMUST00000076961.7 ENSMUST00000076961.8 NM_010261 PRAF1_MOUSE Pra Pra1 Praf1 Q3TDB4 Q9Z0S9 uc009frd.1 uc009frd.2 uc009frd.3 General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1 (By similarity). Homodimer. Interacts with VAMP2 (synaptobrevin-2), GDI1, NRDG1 and PCLO (By similarity). Interacts with prenylated Rab proteins (including RAB5 and RAB6), and with the members of the Ras superfamily HRAS, RHOA, TC21, and RAP1A. Q9Z0S9; P01112: HRAS; Xeno; NbExp=4; IntAct=EBI-476965, EBI-350145; Q9Z0S9; P61586: RHOA; Xeno; NbExp=2; IntAct=EBI-476965, EBI-446668; Cell membrane ; Multi-pass membrane protein Cytoplasm Golgi apparatus Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Note=According to PubMed:11535589, it is an integral membrane protein, while other authors showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles. Belongs to the PRA1 family. Interaction with the Ras-like GTPases failed to be confirmed in other species. protein binding cytoplasm Golgi apparatus plasma membrane synaptic vesicle protein C-terminus binding membrane integral component of membrane cell junction cytoplasmic vesicle identical protein binding synapse proline-rich region binding uc009frd.1 uc009frd.2 uc009frd.3 
ENSMUST00000076982.7 Gm17728 ENSMUST00000076982.7 Gm17728 (from geneSymbol) E9Q5K2 E9Q5K2_MOUSE ENSMUST00000076982.1 ENSMUST00000076982.2 ENSMUST00000076982.3 ENSMUST00000076982.4 ENSMUST00000076982.5 ENSMUST00000076982.6 Gm17728 uc289gxu.1 uc289gxu.2 uc289gxu.1 uc289gxu.2 
ENSMUST00000076989.7 Sohlh1 ENSMUST00000076989.7 spermatogenesis and oogenesis specific basic helix-loop-helix 1, transcript variant 2 (from RefSeq NM_001413658.1) B2RTA1 ENSMUST00000076989.1 ENSMUST00000076989.2 ENSMUST00000076989.3 ENSMUST00000076989.4 ENSMUST00000076989.5 ENSMUST00000076989.6 Gm110 NM_001413658 Q6IUP1 SOLH1_MOUSE Tohlh1 uc008itn.1 uc008itn.2 uc008itn.3 Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation (PubMed:22056784). Coordinates oocyte differentiation without affecting meiosis I (PubMed:28504655). Forms both hetero- and homodimers with SOHLH2. Cytoplasm cleus In males, it is mainly expressed in testis, while in females it is mainly expressed in ovary. In testis, it is exclusively expressed in spermatogonia, with a preference for prespermatogonia and type A spermatogonia. In ovary, it is detected in germ cell cysts, primordial follicles, and primary follicles but is undetectable by the secondary follicle stage (at protein level). Expressed in the majority of spermatogonia in adult animals, but not in the most undifferentiated spermatogonial population (PubMed:22056784). In male testis, it is expressed as early as 12.5 dpc. After birth, it localizes to type A spermatogonia in 7-day-old testis and adult testis, but not in spermatocytes. In spermatogonia, it is initially detected in stage IV Aal spermatogonia and strongly expressed in Aal, A1, A2, A3, A4, intermediate and type B spermatogonia (at protein level). In ovary, it is detected at 15.5 dpc, when oocytes have entered meiosis I, although a low level expression is detectable at 13.5 dpc. Expressed in oocytes of germ cell cysts as well as primordial follicles in the newborn ovary. In adult ovaries, it is preferentially expressed in primordial oocytes but disappear rapidly as the oocytes are recruited to form primary and secondary (multilayer and preantral) follicles. During oocyte differentiation, protein appearance at 15.5 dpc correlates with SOHLH2 translocation from the cytoplasm into the nucleus and is dependent on SOHLH2 expression (PubMed:28504655). Transcription is activated by DMRT1 in undifferentiated spermatogonia. Knockout mice are infertile. Males lacking SOHLH1 display disrupted spermatogonial differentiation into spermatocytes and show a strong down-regulation Lhx8 and Neurog3/Ngn3 genes (PubMed:16564520). Females display perturbed follicular formation, probably partially due to down-regulation of Nobox and Figla, 2 genes required for folliculogenesis (PubMed:16690745). Fertility could be restored by conditional expression of a SOHLH1 transgene after the onset of meiosis (PubMed:28504655). RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ovarian follicle development DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated multicellular organism development spermatogenesis oocyte differentiation regulation of gene expression cell differentiation protein homodimerization activity positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity oogenesis uc008itn.1 uc008itn.2 uc008itn.3 
ENSMUST00000076991.7 4930453N24Rik ENSMUST00000076991.7 RIKEN cDNA 4930453N24 gene (from RefSeq NM_026273.2) A9C482 CC038_MOUSE ENSMUST00000076991.1 ENSMUST00000076991.2 ENSMUST00000076991.3 ENSMUST00000076991.4 ENSMUST00000076991.5 ENSMUST00000076991.6 NM_026273 Q3TTL0 Q8VE03 uc056zco.1 uc056zco.2 uc056zco.3 May be involved in apoptosis regulation. molecular_function nucleus apoptotic process positive regulation of apoptotic process uc056zco.1 uc056zco.2 uc056zco.3 
ENSMUST00000077004.6 Ly6m ENSMUST00000077004.6 lymphocyte antigen 6 family member M (from RefSeq NM_025929.2) 2010109I03Rik ENSMUST00000077004.1 ENSMUST00000077004.2 ENSMUST00000077004.3 ENSMUST00000077004.4 ENSMUST00000077004.5 Ly6m NM_025929 Q9CQ11 Q9CQ11_MOUSE uc007wgg.1 uc007wgg.2 uc007wgg.3 Cell membrane ; Lipid-anchor, GPI-anchor Membrane ; Lipid-anchor, GPI-anchor plasma membrane biological_process membrane acetylcholine receptor inhibitor activity negative regulation of receptor activity uc007wgg.1 uc007wgg.2 uc007wgg.3 
ENSMUST00000077060.3 Or10d4b ENSMUST00000077060.3 olfactory receptor family 10 subfamily D member 4B (from RefSeq NM_146279.1) ENSMUST00000077060.1 ENSMUST00000077060.2 NM_146279 Olfr960 Or10d4b Q8VET5 Q8VET5_MOUSE uc292gbs.1 uc292gbs.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gbs.1 uc292gbs.2 
ENSMUST00000077066.8 Tmem151a ENSMUST00000077066.8 transmembrane protein 151A, transcript variant 1 (from RefSeq NM_001001885.2) ENSMUST00000077066.1 ENSMUST00000077066.2 ENSMUST00000077066.3 ENSMUST00000077066.4 ENSMUST00000077066.5 ENSMUST00000077066.6 ENSMUST00000077066.7 Gm961 NM_001001885 Q6GQT5 T151A_MOUSE Tmem151 uc008gcc.1 uc008gcc.2 uc008gcc.3 Endoplasmic reticulum membrane ; Multi-pass membrane protein Cell projection, axon Cell projection, dendrite Highly expressed in the central nervous system (CNS) including the cerebral cortex, hippocampus, spinal cord, brainstem, and thalamus. Expression is relatively low during postnatal stages but highly expressed at postnatal day 14 (P14), and declined in adulthood. Also expressed in the stomach, heart, liver, spleen, lung, kidney, and muscle. Knockout mice exhibited frequent spontaneous dyskinesia attacks. Belongs to the TMEM151 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008gcc.1 uc008gcc.2 uc008gcc.3 
ENSMUST00000077075.5 Or5g27 ENSMUST00000077075.5 olfactory receptor family 5 subfamily G member 27 (from RefSeq NM_146437.2) ENSMUST00000077075.1 ENSMUST00000077075.2 ENSMUST00000077075.3 ENSMUST00000077075.4 NM_146437 Olfr996 Or5g27 Q7TRA0 Q7TRA0_MOUSE uc008kkk.1 uc008kkk.2 uc008kkk.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC120782.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kkk.1 uc008kkk.2 uc008kkk.3 
ENSMUST00000077078.12 Rnf185 ENSMUST00000077078.12 ring finger protein 185, transcript variant 4 (from RefSeq NR_110959.1) ENSMUST00000077078.1 ENSMUST00000077078.10 ENSMUST00000077078.11 ENSMUST00000077078.2 ENSMUST00000077078.3 ENSMUST00000077078.4 ENSMUST00000077078.5 ENSMUST00000077078.6 ENSMUST00000077078.7 ENSMUST00000077078.8 ENSMUST00000077078.9 NR_110959 Q6ZWS3 Q91YT2 RN185_MOUSE uc007hsw.1 uc007hsw.2 uc007hsw.3 uc007hsw.4 E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (By similarity). Acts in the endoplasmic reticulum (ER)- associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (By similarity). Protects cells from ER stress-induced apoptosis (By similarity). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (By similarity). Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity (PubMed:28273161). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with ATG5 and BNIP1. Mitochondrion outer membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91YT2-1; Sequence=Displayed; Name=2; IsoId=Q91YT2-2; Sequence=VSP_020005; Ubiquitously expressed with high expression in testis. The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity. mitochondrion mitochondrial outer membrane endoplasmic reticulum endoplasmic reticulum membrane ubiquitin-dependent protein catabolic process autophagy membrane integral component of membrane protein ubiquitination transferase activity ER-associated ubiquitin-dependent protein catabolic process ERAD pathway ubiquitin binding ubiquitin-like protein conjugating enzyme binding macromolecular complex binding metal ion binding protein autoubiquitination ubiquitin protein ligase activity ER-associated misfolded protein catabolic process positive regulation of ERAD pathway uc007hsw.1 uc007hsw.2 uc007hsw.3 uc007hsw.4 
ENSMUST00000077115.13 Ptpro ENSMUST00000077115.13 protein tyrosine phosphatase receptor type O, transcript variant 1 (from RefSeq NM_011216.4) E9Q612 ENSMUST00000077115.1 ENSMUST00000077115.10 ENSMUST00000077115.11 ENSMUST00000077115.12 ENSMUST00000077115.2 ENSMUST00000077115.3 ENSMUST00000077115.4 ENSMUST00000077115.5 ENSMUST00000077115.6 ENSMUST00000077115.7 ENSMUST00000077115.8 ENSMUST00000077115.9 GLEPP1 NM_011216 PTPRO_MOUSE PTPU2 Ptpn15 Q7TSY7 uc009emv.1 uc009emv.2 uc009emv.3 uc009emv.4 uc009emv.5 Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Interacts (phosphorylated form) with FYN and GRB2. E9Q612; P27467: Wnt3a; NbExp=2; IntAct=EBI-8183885, EBI-2899665; Membrane ; Single-pass type I membrane protein Modification of podocyte structure such that the normal octopoid podocyte is simplified to a more amoeboid structure and that the foot processes are shorter and broader than normal. These changes are associated with altered distribution of the podocyte intermediate cytoskeletal protein vimentin/VIM. Mutant animals have a reduced glomerular filtration rate and reduced glomerular nephrin (NPHS1) content. However, there is no evidence of proteinuria. After removal of one or more kidneys, Ptpro-null animals have higher blood pressure than does their wild-type littermates. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. cell morphogenesis monocyte chemotaxis regulation of glomerular filtration negative regulation of glomerular filtration phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding plasma membrane protein dephosphorylation axon guidance membrane integral component of membrane dephosphorylation apical plasma membrane lateral plasma membrane hydrolase activity phosphatase activity Wnt-protein binding lamellipodium assembly glomerulus development peptidyl-tyrosine dephosphorylation slit diaphragm assembly protein homodimerization activity dendritic spine cadherin binding regulation of synapse organization glomerular visceral epithelial cell differentiation negative regulation of canonical Wnt signaling pathway glutamatergic synapse GABA-ergic synapse integral component of postsynaptic density membrane uc009emv.1 uc009emv.2 uc009emv.3 uc009emv.4 uc009emv.5 
ENSMUST00000077119.8 Gjc3 ENSMUST00000077119.8 gap junction protein, gamma 3, transcript variant 1 (from RefSeq NM_080450.5) CXG3_MOUSE Cx29 ENSMUST00000077119.1 ENSMUST00000077119.2 ENSMUST00000077119.3 ENSMUST00000077119.4 ENSMUST00000077119.5 ENSMUST00000077119.6 ENSMUST00000077119.7 Gje1 NM_080450 Q53ZP5 Q8BHJ3 Q921C1 uc009aeg.1 uc009aeg.2 uc009aeg.3 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Cell membrane ; Multi-pass membrane protein Cell junction, gap junction CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve. Belongs to the connexin family. Gamma-type subfamily. It is uncertain whether Met-1 or Met-12 is the initiator. gap junction channel activity plasma membrane gap junction connexin complex cell communication cell-cell signaling sensory perception of sound membrane integral component of membrane cell junction myelination protein homodimerization activity myelin sheath transmembrane transport uc009aeg.1 uc009aeg.2 uc009aeg.3 
ENSMUST00000077136.5 Sftpd ENSMUST00000077136.5 surfactant associated protein D (from RefSeq NM_009160.2) ENSMUST00000077136.1 ENSMUST00000077136.2 ENSMUST00000077136.3 ENSMUST00000077136.4 NM_009160 P50404 SFTPD_MOUSE Sftp4 uc007tcr.1 uc007tcr.2 uc007tcr.3 uc007tcr.4 Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties. Oligomeric complex of 4 set of homotrimers. P50404; P50404: Sftpd; NbExp=2; IntAct=EBI-8402361, EBI-8402361; Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. S-nitrosylation at Cys-34 and Cys-39 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages. Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C). Belongs to the SFTPD family. Name=Functional Glycomics Gateway - Glycan Binding; Note=Pulmonary surfactant protein SP-D; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_170"; lipopolysaccharide binding immune system process extracellular region collagen trimer extracellular space cytoplasm multivesicular body rough endoplasmic reticulum respiratory gaseous exchange opsonization carbohydrate binding cytoplasmic vesicle developmental process negative regulation of interleukin-2 production negative regulation of T cell proliferation identical protein binding surfactant homeostasis induction of bacterial agglutination innate immune response monosaccharide binding lung alveolus development negative regulation of phagocytosis positive regulation of phagocytosis regulation of liquid surface tension negative regulation by host of symbiont molecular function regulation of adhesion of symbiont to host epithelial cell uc007tcr.1 uc007tcr.2 uc007tcr.3 uc007tcr.4 
ENSMUST00000077146.4 Dsg1a ENSMUST00000077146.4 desmoglein 1 alpha (from RefSeq NM_010079.3) A8WFQ4 DSG1A_MOUSE Dsg1 ENSMUST00000077146.1 ENSMUST00000077146.2 ENSMUST00000077146.3 NM_010079 Q61495 Q8CE03 uc008eel.1 uc008eel.2 uc008eel.3 uc008eel.4 This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC154410.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849387 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Binds to JUP/plakoglobin (By similarity). Interacts with PKP2 (By similarity). Cell membrane ; Single-pass type I membrane protein Cell junction, desmosome. Cytoplasm Nucleus Expressed in testis. Expressed in embryo at 17 dpc. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Sequence=BAC26378.1; Type=Frameshift; Evidence=; calcium ion binding protein binding plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cytoplasmic side of plasma membrane membrane integral component of membrane apical plasma membrane lateral plasma membrane cell junction desmosome gamma-catenin binding metal ion binding cell-cell adhesion uc008eel.1 uc008eel.2 uc008eel.3 uc008eel.4 
ENSMUST00000077173.13 Dppa1 ENSMUST00000077173.13 developmental pluripotency associated 1, transcript variant 1 (from RefSeq NM_178247.3) Dppa1 ENSMUST00000077173.1 ENSMUST00000077173.10 ENSMUST00000077173.11 ENSMUST00000077173.12 ENSMUST00000077173.2 ENSMUST00000077173.3 ENSMUST00000077173.4 ENSMUST00000077173.5 ENSMUST00000077173.6 ENSMUST00000077173.7 ENSMUST00000077173.8 ENSMUST00000077173.9 NM_178247 Q810Y7 Q810Y7_MOUSE uc007iop.1 uc007iop.2 uc007iop.3 uc007iop.4 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007iop.1 uc007iop.2 uc007iop.3 uc007iop.4 
ENSMUST00000077175.7 Polr3b ENSMUST00000077175.7 polymerase (RNA) III (DNA directed) polypeptide B (from RefSeq NM_027423.2) ENSMUST00000077175.1 ENSMUST00000077175.2 ENSMUST00000077175.3 ENSMUST00000077175.4 ENSMUST00000077175.5 ENSMUST00000077175.6 NM_027423 P59470 Polr3b Q6NVF3 RPC2_MOUSE uc007gku.1 uc007gku.2 uc007gku.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Second largest core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (By similarity). Pol III-mediated transcription proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol III is recruited to DNA promoters type I, II or III with the help of general transcription factors and other specific initiation factors. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity). Forms Pol III active center together with the largest subunit POLR3A/RPC1. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from POLR3A/RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the DNA-RNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR3A/RPC1 most likely contributing a Mg(2+)- coordinating DxDGD motif, and POLR3B/RPC2 providing lysine residues involved in catalysis. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphoester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein- Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity). Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA- COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21249; Evidence=; Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3- POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Nucleus Cytoplasm, cytosol Belongs to the RNA polymerase beta chain family. Sequence=AAH44796.1; Type=Erroneous initiation; Evidence=; immune system process DNA binding DNA-directed 5'-3' RNA polymerase activity nucleus DNA-directed RNA polymerase III complex transcription, DNA-templated transcription from RNA polymerase III promoter transferase activity nucleotidyltransferase activity ribonucleoside binding positive regulation of interferon-beta production innate immune response positive regulation of innate immune response metal ion binding defense response to virus RNA polymerase III activity uc007gku.1 uc007gku.2 uc007gku.3 
ENSMUST00000077182.13 Nrxn2 ENSMUST00000077182.13 neurexin II, transcript variant 3 (from RefSeq NM_001205235.2) E9Q5N7 E9Q5N7_MOUSE ENSMUST00000077182.1 ENSMUST00000077182.10 ENSMUST00000077182.11 ENSMUST00000077182.12 ENSMUST00000077182.2 ENSMUST00000077182.3 ENSMUST00000077182.4 ENSMUST00000077182.5 ENSMUST00000077182.6 ENSMUST00000077182.7 ENSMUST00000077182.8 ENSMUST00000077182.9 NM_001205235 Nrxn2 uc012bhm.1 uc012bhm.2 uc012bhm.3 uc012bhm.4 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc012bhm.1 uc012bhm.2 uc012bhm.3 uc012bhm.4 
ENSMUST00000077191.7 Ethe1 ENSMUST00000077191.7 ethylmalonic encephalopathy 1, transcript variant 1 (from RefSeq NM_023154.4) ENSMUST00000077191.1 ENSMUST00000077191.2 ENSMUST00000077191.3 ENSMUST00000077191.4 ENSMUST00000077191.5 ENSMUST00000077191.6 ETHE1_MOUSE Hsco NM_023154 Q9DCM0 Q9ESL5 uc009fqb.1 uc009fqb.2 uc009fqb.3 uc009fqb.4 First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (By similarity). Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R- SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. Reaction=H2O + O2 + S-sulfanylglutathione = glutathione + 2 H(+) + sulfite; Xref=Rhea:RHEA:12981, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17359, ChEBI:CHEBI:57925, ChEBI:CHEBI:58905; EC=1.13.11.18; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Homodimer. Monomer. Interacts with TST. May interact with RELA. Cytoplasm Nucleus Mitochondrion matrix Mice are born at slightly less than the expected Mendelian rate. Pups display growth arrest at about 15 days after birth and die five to six weeks after birth. Mice exhibit elevated levels of hydrogen sulfide (H(2)S) in liver, muscle and brain, together with increased urinary levels of ethylmalonic acid and thiosulfate. Their mitochondria show decreased cytochrome c oxidase activity, probably due to the toxic effects of supraphysiological levels of hydrogen sulfide. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. iron ion binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial matrix glutathione metabolic process oxidoreductase activity hydrolase activity, acting on ester bonds metal ion binding sulfur dioxygenase activity dioxygenase activity oxidation-reduction process hydrogen sulfide metabolic process uc009fqb.1 uc009fqb.2 uc009fqb.3 uc009fqb.4 
ENSMUST00000077194.2 Tpte ENSMUST00000077194.2 transmembrane phosphatase with tensin homology (from RefSeq NM_199257.3) ENSMUST00000077194.1 G5E8H5 G5E8H5_MOUSE NM_199257 Tpte uc009lcy.1 uc009lcy.2 molecular_function protein tyrosine phosphatase activity cytoplasm endoplasmic reticulum membrane Golgi apparatus protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity biological_process membrane integral component of membrane dephosphorylation hydrolase activity peptidyl-tyrosine dephosphorylation uc009lcy.1 uc009lcy.2 
ENSMUST00000077196.6 Krt80 ENSMUST00000077196.6 keratin 80 (from RefSeq NM_028770.3) ENSMUST00000077196.1 ENSMUST00000077196.2 ENSMUST00000077196.3 ENSMUST00000077196.4 ENSMUST00000077196.5 K2C80_MOUSE Kb20 NM_028770 Q0VBK2 uc007xtb.1 uc007xtb.2 uc007xtb.3 Heterotetramer of two type I and two type II keratins. There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively). Belongs to the intermediate filament family. cytoplasm intermediate filament keratin filament intermediate filament cytoskeleton uc007xtb.1 uc007xtb.2 uc007xtb.3 
ENSMUST00000077208.6 ENSMUSG00000121644 ENSMUST00000077208.6 ENSMUSG00000121644 (from geneSymbol) ENSMUST00000077208.1 ENSMUST00000077208.2 ENSMUST00000077208.3 ENSMUST00000077208.4 ENSMUST00000077208.5 uc292dbl.1 uc292dbl.2 uc292dbl.1 uc292dbl.2 
ENSMUST00000077210.3 Or14a258 ENSMUST00000077210.3 olfactory receptor family 14 subfamily A member 258 (from RefSeq NM_001011828.1) ENSMUST00000077210.1 ENSMUST00000077210.2 NM_001011828 Olfr304 Or14a258 Q7TS03 Q7TS03_MOUSE uc009iex.1 uc009iex.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009iex.1 uc009iex.2 
ENSMUST00000077220.14 Gtpbp6 ENSMUST00000077220.14 GTP binding protein 6 (putative), transcript variant 2 (from RefSeq NR_189623.1) A0A0R4J0Z0 A0A0R4J0Z0_MOUSE ENSMUST00000077220.1 ENSMUST00000077220.10 ENSMUST00000077220.11 ENSMUST00000077220.12 ENSMUST00000077220.13 ENSMUST00000077220.2 ENSMUST00000077220.3 ENSMUST00000077220.4 ENSMUST00000077220.5 ENSMUST00000077220.6 ENSMUST00000077220.7 ENSMUST00000077220.8 ENSMUST00000077220.9 Gtpbp6 NR_189623 uc008ypr.1 uc008ypr.2 uc008ypr.3 uc008ypr.4 GTP binding uc008ypr.1 uc008ypr.2 uc008ypr.3 uc008ypr.4 
ENSMUST00000077221.6 Sgcd ENSMUST00000077221.6 sarcoglycan, delta (dystrophin-associated glycoprotein) (from RefSeq NM_011891.5) ENSMUST00000077221.1 ENSMUST00000077221.2 ENSMUST00000077221.3 ENSMUST00000077221.4 ENSMUST00000077221.5 NM_011891 Q544D4 Q544D4_MOUSE Sgcd uc007ioz.1 uc007ioz.2 uc007ioz.3 Cell membrane, sarcolemma ; Single-pass type II membrane protein Belongs to the sarcoglycan beta/delta/gamma/zeta family. dystrophin-associated glycoprotein complex sarcoglycan complex membrane integral component of membrane uc007ioz.1 uc007ioz.2 uc007ioz.3 
ENSMUST00000077247.3 Or10ak13 ENSMUST00000077247.3 olfactory receptor family 10 subfamily AK member 13 (from RefSeq NM_146309.3) A2ACY8 A2ACY8_MOUSE ENSMUST00000077247.1 ENSMUST00000077247.2 NM_146309 Olfr1337 Or10ak13 uc008ukv.1 uc008ukv.2 uc008ukv.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC152318.1, BC127989.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008ukv.1 uc008ukv.2 uc008ukv.3 
ENSMUST00000077257.12 Rxra ENSMUST00000077257.12 retinoid X receptor alpha, transcript variant 1 (from RefSeq NM_011305.3) ENSMUST00000077257.1 ENSMUST00000077257.10 ENSMUST00000077257.11 ENSMUST00000077257.2 ENSMUST00000077257.3 ENSMUST00000077257.4 ENSMUST00000077257.5 ENSMUST00000077257.6 ENSMUST00000077257.7 ENSMUST00000077257.8 ENSMUST00000077257.9 NM_011305 Nr2b1 P28700 RXRA_MOUSE uc008ixs.1 uc008ixs.2 uc008ixs.3 Receptor for retinoic acid that acts as a transcription factor (PubMed:10383391, PubMed:12032153, PubMed:25417649). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9- cis retinoic acid, to regulate gene expression in various biological processes (PubMed:1310259, PubMed:10383391). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:1310259). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:10383391, PubMed:25417649). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (By similarity). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:1310259). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (By similarity). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (By similarity). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (By similarity). Acts as an enhancer of RARA binding to RARE DNA element (By similarity). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (By similarity). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (By similarity). Homodimer (By similarity). Heterodimer with RARA; required for ligand-dependent retinoic acid receptor transcriptional activity (PubMed:10882070). Heterodimer with PPARA (via the leucine-like zipper in the LBD); the interaction is required for PPARA transcriptional activity (By similarity). Heterodimerizes with PPARG (PubMed:7838715). Heterodimerizes (via NR LBD) with RARB (By similarity). Heterodimerizes with NR1H4; the heterodimerization enhances the binding affinity for LXXLL motifs from coactivators (By similarity). Interacts with coactivator NCO6 (PubMed:10788465). Interacts with coactivator NCO3 (By similarity). Interacts with coactivator FAM120B (PubMed:17595322). Interacts with coactivator PELP1, SENP6, SFPQ, DNTTIP2 and RNF8 (By similarity). Interacts with PRMT2 (By similarity). Interacts with ASXL1 (PubMed:16606617). Interacts with BHLHE40/DEC1, BHLHE41/DEC2, NCOR1 and NCOR2 (By similarity). Interacts in a ligand-dependent fashion with MED1 and NCOA1 (PubMed:15528208, PubMed:16606617). Interacts with VDR (By similarity). Interacts with EP300; the interaction is decreased by 9-cis retinoic acid (By similarity). Heterodimer (via C-terminus) with NR4A1 (via DNA-binding domain); the interaction is enhanced by 9-cis retinoic acid (By similarity). NR4A1 competes with EP300 for interaction with RXRA and thereby attenuates EP300 mediated acetylation of RXRA (By similarity). In the absence of hormonal ligand, interacts with TACC1 (PubMed:20078863). P28700; P59598: Asxl1; NbExp=2; IntAct=EBI-346715, EBI-5743705; P28700; Q64337: Sqstm1; NbExp=3; IntAct=EBI-346715, EBI-645025; P28700; Q8IXJ9: ASXL1; Xeno; NbExp=2; IntAct=EBI-346715, EBI-1646500; P28700; Q71SY5: MED25; Xeno; NbExp=3; IntAct=EBI-346715, EBI-394558; P28700; P23246-1: SFPQ; Xeno; NbExp=3; IntAct=EBI-346715, EBI-355463; P28700; Q13501: SQSTM1; Xeno; NbExp=3; IntAct=EBI-346715, EBI-307104; P28700; P11473: VDR; Xeno; NbExp=3; IntAct=EBI-346715, EBI-286357; Nucleus Cytoplasm Mitochondrion Note=Localization to the nucleus is enhanced by vitamin D3 (By similarity). Nuclear localization may be enhanced by the interaction with heterodimerization partner VDR (By similarity). Translocation to the mitochondrion upon interaction with NR4A1 (By similarity). Increased nuclear localization upon pulsatile shear stress (By similarity). Expressed in macrophages (at protein level). Down-regulated by infection with viruses, such as VSV, HSV-1 and MHV68 (PubMed:25417649). Down-regulated by aging (PubMed:26463675). Composed of three domains: a modulating N-terminal or AF1 domain, a DNA-binding domain and a C-terminal ligand-binding or AF2 domain. Acetylated by EP300; acetylation enhances DNA binding and transcriptional activity. Phosphorylated on serine and threonine residues mainly in the N- terminal modulating domain (PubMed:10383391, PubMed:12032153). Constitutively phosphorylated on Ser-22 in the presence or absence of ligand (PubMed:10383391, PubMed:12032153). Under stress conditions, hyperphosphorylated by activated JNK on Ser-61, Ser-75, Thr-87 and Ser- 265 (PubMed:10383391). Phosphorylated on Ser-28, in vitro, by PKA (By similarity). This phosphorylation is required for repression of cAMP- mediated transcriptional activity of RARA (By similarity). Sumoylation negatively regulates transcriptional activity. Desumoylated specifically by SENP6. Reduced myelin debris uptake by bone marrow- derived macrophages (PubMed:26463675). Conditional knockout in myeloid cells results in reduced myelin debris clearing by macrophages, delayed oligodendrocyte progenitor cell differentiation and slowern remyelination after induced focal demyelination (PubMed:26463675). Belongs to the nuclear hormone receptor family. NR2 subfamily. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding in utero embryonic development placenta development maternal placenta development retinoic acid binding heart morphogenesis DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm mitochondrion regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter heart development embryo implantation transcription factor binding zinc ion binding negative regulation of cell proliferation negative regulation of gene expression ligand-dependent nuclear receptor binding modulation by virus of host morphology or physiology enzyme binding protein domain specific binding cell differentiation axon chromatin DNA binding regulation of myelination response to retinoic acid macromolecular complex peroxisome proliferator activated receptor signaling pathway peptide binding identical protein binding vitamin D receptor binding retinoic acid receptor binding camera-type eye development positive regulation of apoptotic process receptor complex steroid hormone mediated signaling pathway sequence-specific DNA binding transcription regulatory region DNA binding retinoic acid-responsive element binding macromolecular complex binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation by iron metal ion binding protein heterodimerization activity retinoic acid receptor signaling pathway anatomical structure development DBD domain binding LBD domain binding response to glucocorticoid cardiac muscle cell differentiation ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle cell differentiation cardiac muscle cell proliferation mesenchyme development secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development regulation of branching involved in prostate gland morphogenesis angiogenesis involved in coronary vascular morphogenesis visceral serous pericardium development vitamin D response element binding RNA polymerase II transcription factor complex positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus uc008ixs.1 uc008ixs.2 uc008ixs.3 
ENSMUST00000077271.9 Gfm1 ENSMUST00000077271.9 G elongation factor, mitochondrial 1 (from RefSeq NM_138591.2) EFGM_MOUSE ENSMUST00000077271.1 ENSMUST00000077271.2 ENSMUST00000077271.3 ENSMUST00000077271.4 ENSMUST00000077271.5 ENSMUST00000077271.6 ENSMUST00000077271.7 ENSMUST00000077271.8 Efg Efg1 Gfm NM_138591 Q8K0D5 Q921D6 Q924I0 uc008plm.1 uc008plm.2 uc008plm.3 uc008plm.4 Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Protein biosynthesis; polypeptide chain elongation. Mitochondrion. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. nucleotide binding translation elongation factor activity GTPase activity GTP binding mitochondrion translation translational elongation mitochondrial translational elongation uc008plm.1 uc008plm.2 uc008plm.3 uc008plm.4 
ENSMUST00000077273.9 Ext1 ENSMUST00000077273.9 exostosin glycosyltransferase 1 (from RefSeq NM_010162.2) ENSMUST00000077273.1 ENSMUST00000077273.2 ENSMUST00000077273.3 ENSMUST00000077273.4 ENSMUST00000077273.5 ENSMUST00000077273.6 ENSMUST00000077273.7 ENSMUST00000077273.8 Ext1 NM_010162 Q3V1P4 Q3V1P4_MOUSE uc007vrh.1 uc007vrh.2 uc007vrh.3 uc007vrh.4 Endoplasmic reticulum membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 47 family. ossification endoplasmic reticulum Golgi apparatus glycosaminoglycan biosynthetic process protein glycosylation brain development acetylglucosaminyltransferase activity heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process glucuronosyltransferase activity membrane integral component of membrane transferase activity, transferring glycosyl groups cellular polysaccharide biosynthetic process protein homodimerization activity protein heterodimerization activity uc007vrh.1 uc007vrh.2 uc007vrh.3 uc007vrh.4 
ENSMUST00000077282.7 Atrnl1 ENSMUST00000077282.7 attractin like 1 (from RefSeq NM_181415.4) ATRN1_MOUSE Alp Atrnl ENSMUST00000077282.1 ENSMUST00000077282.2 ENSMUST00000077282.3 ENSMUST00000077282.4 ENSMUST00000077282.5 ENSMUST00000077282.6 Kiaa0534 NM_181415 Q3UHB0 Q68HV2 Q6A051 Q80VI3 Q8BKS4 Q8K0P5 uc008iai.1 uc008iai.2 uc008iai.3 uc008iai.4 uc008iai.5 uc008iai.6 May play a role in melanocortin signaling pathways that regulate energy homeostasis. Interacts with MC4R. Cell membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6A051-1; Sequence=Displayed; Name=2; IsoId=Q6A051-2; Sequence=VSP_033722, VSP_033723; Name=3; IsoId=Q6A051-3; Sequence=VSP_033720, VSP_033721; Highly expressed in brain, heart, lung, kidney and liver. In the central nervous system, it is highly expressed in the dentate gyrus, CA1-3 regions of the hippocampus, and the ventral taenia tecta. Mice are grossly normal with no alterations of pigmentation, central nervous system pathology or body weight. In contrast, constitutive expression of Atrnl1 in mice lacking Atrn display normal, agouti-banded hairs and significantly delayed onset of spongiform neurodegeneration, indicating that overexpression of Atrnl1 compensates for loss of Atrn. Sequence=BAD32245.1; Type=Erroneous initiation; Evidence=; protein binding cellular_component plasma membrane G-protein coupled receptor signaling pathway animal organ morphogenesis tissue development membrane integral component of membrane carbohydrate binding uc008iai.1 uc008iai.2 uc008iai.3 uc008iai.4 uc008iai.5 uc008iai.6 
ENSMUST00000077290.9 Pdia4 ENSMUST00000077290.9 protein disulfide isomerase associated 4, transcript variant 2 (from RefSeq NM_009787.2) A0A0R4J0Z1 A0A0R4J0Z1_MOUSE ENSMUST00000077290.1 ENSMUST00000077290.2 ENSMUST00000077290.3 ENSMUST00000077290.4 ENSMUST00000077290.5 ENSMUST00000077290.6 ENSMUST00000077290.7 ENSMUST00000077290.8 NM_009787 Pdia4 uc009btf.1 uc009btf.2 uc009btf.3 Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; Evidence= Part of a large chaperone multiprotein complex. Endoplasmic reticulum lumen Melanosome Belongs to the protein disulfide isomerase family. protein disulfide isomerase activity endoplasmic reticulum endoplasmic reticulum lumen isomerase activity cell redox homeostasis uc009btf.1 uc009btf.2 uc009btf.3 
ENSMUST00000077337.9 Irx1 ENSMUST00000077337.9 Iroquois homeobox 1 (from RefSeq NM_010573.2) ENSMUST00000077337.1 ENSMUST00000077337.2 ENSMUST00000077337.3 ENSMUST00000077337.4 ENSMUST00000077337.5 ENSMUST00000077337.6 ENSMUST00000077337.7 ENSMUST00000077337.8 G5E8H6 IRX1_MOUSE Irxa1 NM_010573 O55120 P81068 Q3UZB9 Q9JLL6 uc007rdd.1 uc007rdd.2 uc007rdd.3 Nucleus Expressed in specific and overlapping patterns with Irx1 and Irx2 in the developing and adult metanephric kidney. In the adult metanephros, renal expression is found in the loop of Henle in the S3 proximal tubule segment and in the thick ascending limb (TAL) of the distal tubule. First detected in the mesoderm at stage 7.5 dpc. During neurogenesis (9.5 dpc to 10.5 dpc), predominantly expressed along the anteroposterior axis of the CNS in the mesencephalon, metencephalon, rhombencephalon and spinal cord, with expression excluded from the midbrain-hindbrain junction. Beginning at 9.5 dpc, expression is found in the epithelial component of the branchial arches and foregut. At later stages, expressed in somites. At 10.5 dpc, expressed in the cephalic mesenchyme surrounding the optic vesicle. By 12.5 dpc, expression remains in the mesenchyme and also begins in the neuroretina, and at 16.5 dpc expression is exclusively located in the inner neuroblast layers of the neuroretina. Starting at the otic vesicle stage, shows regionalized expression in the developing inner ear with expression in the entire otic vesicle from 10.5 dpc onwards. Expressed in distinct patterns in the developing limb buds from 10.5 dpc onwards. Expressed in the developing heart in the ventricular septum from the onset of its formation (10.5 dpc) onward. In fetal stages, expression becomes confined to the myocardium of the atrioventricular bundle and bundle branches of the forming ventricular conduction system. Belongs to the TALE/IRO homeobox family. negative regulation of transcription from RNA polymerase II promoter metanephros development DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding specification of loop of Henle identity proximal/distal pattern formation involved in metanephric nephron development uc007rdd.1 uc007rdd.2 uc007rdd.3 
ENSMUST00000077338.12 Dmac2 ENSMUST00000077338.12 distal membrane arm assembly complex 2, transcript variant 1 (from RefSeq NM_001290487.1) Atp5sl DMAC2_MOUSE ENSMUST00000077338.1 ENSMUST00000077338.10 ENSMUST00000077338.11 ENSMUST00000077338.2 ENSMUST00000077338.3 ENSMUST00000077338.4 ENSMUST00000077338.5 ENSMUST00000077338.6 ENSMUST00000077338.7 ENSMUST00000077338.8 ENSMUST00000077338.9 NM_001290487 Q9D7K5 uc009fte.1 uc009fte.2 uc009fte.3 uc009fte.4 Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. Interacts with incompletely assembled mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Mitochondrion Belongs to the ATP synthase subunit s family. mitochondrion mitochondrial respiratory chain complex I ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process mitochondrial respiratory chain complex I assembly ubiquitin-protein transferase activity uc009fte.1 uc009fte.2 uc009fte.3 uc009fte.4 
ENSMUST00000077340.14 Rnpep ENSMUST00000077340.14 arginyl aminopeptidase (aminopeptidase B), transcript variant 3 (from RefSeq NR_185276.1) AMPB_MOUSE ENSMUST00000077340.1 ENSMUST00000077340.10 ENSMUST00000077340.11 ENSMUST00000077340.12 ENSMUST00000077340.13 ENSMUST00000077340.2 ENSMUST00000077340.3 ENSMUST00000077340.4 ENSMUST00000077340.5 ENSMUST00000077340.6 ENSMUST00000077340.7 ENSMUST00000077340.8 ENSMUST00000077340.9 NR_185276 Q3TX27 Q8VCT3 uc007csy.1 uc007csy.2 uc007csy.3 uc007csy.4 Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)- somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). Reaction=Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys.; EC=3.4.11.6; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Monomer. Secreted. Belongs to the peptidase M1 family. aminopeptidase activity copper ion binding extracellular region extracellular space Golgi apparatus plasma membrane proteolysis peptidase activity metallopeptidase activity zinc ion binding external side of plasma membrane hydrolase activity secretory granule peptide binding neuron projection negative regulation of blood pressure metal ion binding cobalt ion binding metalloaminopeptidase activity uc007csy.1 uc007csy.2 uc007csy.3 uc007csy.4 
ENSMUST00000077347.3 Or7g31 ENSMUST00000077347.3 olfactory receptor family 7 subfamily G member 32 (from RefSeq NM_146523.1) ENSMUST00000077347.1 ENSMUST00000077347.2 NM_146523 Olfr845 Olfr850 Or7g31 Q8VFF2 Q8VFF2_MOUSE uc009ohk.1 uc009ohk.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC113136.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ohk.1 uc009ohk.2 
ENSMUST00000077353.15 Hmbs ENSMUST00000077353.15 hydroxymethylbilane synthase, transcript variant 1 (from RefSeq NM_013551.2) ENSMUST00000077353.1 ENSMUST00000077353.10 ENSMUST00000077353.11 ENSMUST00000077353.12 ENSMUST00000077353.13 ENSMUST00000077353.14 ENSMUST00000077353.2 ENSMUST00000077353.3 ENSMUST00000077353.4 ENSMUST00000077353.5 ENSMUST00000077353.6 ENSMUST00000077353.7 ENSMUST00000077353.8 ENSMUST00000077353.9 HEM3_MOUSE NM_013551 P22907 Q3TIV0 Uros1 uc009pda.1 uc009pda.2 uc009pda.3 uc009pda.4 As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact. Reaction=H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+); Xref=Rhea:RHEA:13185, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57845, ChEBI:CHEBI:58126; EC=2.5.1.61; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13186; Evidence=; Name=dipyrromethane; Xref=ChEBI:CHEBI:60342; Evidence=; Note=Binds 1 dipyrromethane group covalently. ; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. Monomer. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Non-erythropoietic; IsoId=P22907-1; Sequence=Displayed; Name=2; Synonyms=Erythrocyte; IsoId=P22907-2; Sequence=VSP_002068; Belongs to the HMBS family. Sequence=AAA39890.1; Type=Erroneous gene model prediction; Evidence=; hydroxymethylbilane synthase activity uroporphyrinogen-III synthase activity nucleus cytoplasm porphyrin-containing compound biosynthetic process protoporphyrinogen IX biosynthetic process heme biosynthetic process transferase activity peptidyl-pyrromethane cofactor linkage axon carboxylic acid binding tetrapyrrole biosynthetic process amine binding coenzyme binding condensed chromosome uc009pda.1 uc009pda.2 uc009pda.3 uc009pda.4 
ENSMUST00000077354.5 Klk1b4 ENSMUST00000077354.5 kallikrein 1-related pepidase b4 (from RefSeq NM_010915.4) ENSMUST00000077354.1 ENSMUST00000077354.2 ENSMUST00000077354.3 ENSMUST00000077354.4 K1KB4_MOUSE Klk-4 Klk4 NM_010915 Ngfa P00757 uc009gom.1 uc009gom.2 uc009gom.3 uc009gom.4 uc009gom.5 This gene encodes the alpha subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034518.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per 7S complex. The Zn(2+) ions are bound at the alpha-gamma interfaces.; 7S nerve growth factor is composed of two alpha chains, a beta dimer composed of identical chains, and two gamma chains. The presence of Gln-24 prevents cleavage of the activation peptide, which remains attached at the amino end of the mature alpha chain. Belongs to the peptidase S1 family. Kallikrein subfamily. Has no demonstrable enzymatic activity. This may be due to several critical changes in its sequence, relative to those of related proteases. regulation of systemic arterial blood pressure endopeptidase activity serine-type endopeptidase activity extracellular space proteolysis small GTPase mediated signal transduction growth factor activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides secretory granule zymogen activation macromolecular complex positive regulation of phosphatidylinositol 3-kinase activity metal ion binding uc009gom.1 uc009gom.2 uc009gom.3 uc009gom.4 uc009gom.5 
ENSMUST00000077356.7 Cyp2b23 ENSMUST00000077356.7 cytochrome P450, family 2, subfamily b, polypeptide 23 (from RefSeq NM_001081148.1) Cyp2b23 E9Q593 E9Q593_MOUSE ENSMUST00000077356.1 ENSMUST00000077356.2 ENSMUST00000077356.3 ENSMUST00000077356.4 ENSMUST00000077356.5 ENSMUST00000077356.6 NM_001081148 uc009fur.1 uc009fur.2 uc009fur.3 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc009fur.1 uc009fur.2 uc009fur.3 
ENSMUST00000077367.11 Gba1 ENSMUST00000077367.11 glucosylceramidase beta 1, transcript variant 10 (from RefSeq NR_176923.1) ENSMUST00000077367.1 ENSMUST00000077367.10 ENSMUST00000077367.2 ENSMUST00000077367.3 ENSMUST00000077367.4 ENSMUST00000077367.5 ENSMUST00000077367.6 ENSMUST00000077367.7 ENSMUST00000077367.8 ENSMUST00000077367.9 GBA1_MOUSE Gba NR_176923 P17439 Q78NR7 uc008pyc.1 uc008pyc.2 uc008pyc.3 uc008pyc.4 Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta- D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose (PubMed:24211208). Plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698). Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation (By similarity). Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol (PubMed:24211208). GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine) (By similarity). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide (By similarity). Can also hydrolyze cholesteryl 3-beta-D- glucoside producing glucose and cholesterol (By similarity). Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D- galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers (By similarity). Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N- acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside (By similarity). Reaction=a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N- acylsphing-4-enine + D-glucose; Xref=Rhea:RHEA:13269, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:22801, ChEBI:CHEBI:52639; EC=3.2.1.45; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13270; Evidence=; Reaction=a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose; Xref=Rhea:RHEA:14297, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377, ChEBI:CHEBI:18390, ChEBI:CHEBI:52639; EC=3.2.1.46; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14298; Evidence=; Reaction=cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D- glucose; Xref=Rhea:RHEA:11956, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11957; Evidence=; Reaction=a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside; Xref=Rhea:RHEA:58264, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:22801, ChEBI:CHEBI:52639; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58265; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:58266; Evidence=; Reaction=beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing- 4-enine; Xref=Rhea:RHEA:58316, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:72959, ChEBI:CHEBI:84716; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58317; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:58318; Evidence=; Reaction=beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)- sphing-4-enine; Xref=Rhea:RHEA:58324, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:77996, ChEBI:CHEBI:139140; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58325; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:58326; Evidence=; Reaction=beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine; Xref=Rhea:RHEA:70303, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:45815, ChEBI:CHEBI:65222; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70304; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70305; Evidence=; Reaction=beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine; Xref=Rhea:RHEA:70307, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:72956, ChEBI:CHEBI:76297; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70308; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70309; Evidence=; Reaction=beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing- 4-enine; Xref=Rhea:RHEA:70311, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:72961, ChEBI:CHEBI:84719; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70312; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70313; Evidence=; Reaction=beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(15Z- tetracosenoyl)-sphing-4-enine; Xref=Rhea:RHEA:70315, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:74450, ChEBI:CHEBI:76302; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70316; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70317; Evidence=; Reaction=a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D- galactoside; Xref=Rhea:RHEA:70235, ChEBI:CHEBI:16113, ChEBI:CHEBI:18390, ChEBI:CHEBI:52639, ChEBI:CHEBI:189066; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70236; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70237; Evidence=; Reaction=1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine; Xref=Rhea:RHEA:70255, ChEBI:CHEBI:16113, ChEBI:CHEBI:72956, ChEBI:CHEBI:73432, ChEBI:CHEBI:189066; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70256; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70257; Evidence=; Reaction=a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside; Xref=Rhea:RHEA:70239, ChEBI:CHEBI:16113, ChEBI:CHEBI:52639, ChEBI:CHEBI:189067, ChEBI:CHEBI:189068; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70240; Evidence=; Reaction=beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)- sphing-4-enine; Xref=Rhea:RHEA:70251, ChEBI:CHEBI:16113, ChEBI:CHEBI:77996, ChEBI:CHEBI:189067, ChEBI:CHEBI:189081; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70252; Evidence=; Inhibited by conduritol B epoxide/CBE. Steroid metabolism; cholesterol metabolism. Sphingolipid metabolism. Interacts with saposin-C. Interacts with SCARB2. Interacts with TCP1 (By similarity). Interacts with GRN; this interaction prevents aggregation of GBA1-SCARB2 complex via interaction with HSPA1A upon stress (PubMed:27789271). Lysosome membrane ; Peripheral membrane protein ; Lumenal side Note=Interaction with saposin-C promotes membrane [?]association. Targeting to lysosomes occurs through an alternative MPR-independent mechanism via SCARB2. Homozygous knockout mice die within 24 hours of birth (PubMed:1594045). They are under weight, respire abnormally and show rapidly progressing cyanosis (PubMed:1594045). Feeding and movement are also decreased in these mice (PubMed:1594045). Macrophages accumulating glucosylceramides in tubular lysosomal deposits are found in liver (in Kupffer cells), bone marrow, spleen and brain (PubMed:1594045). Hematopoietic stem cells conditional knockout of GBA1, leads to widespread and organ-specific dysfunction of immune cells. Thymus shows the earliest alteration with features of impaired T-cell maturation, aberrant B-cell recruitment, enhanced antigen presentation, and impaired egress of mature thymocytes (PubMed:22665763). Belongs to the glycosyl hydrolase 30 family. glucosylceramidase activity receptor binding scavenger receptor binding protein binding extracellular space lysosome lysosomal membrane endoplasmic reticulum Golgi apparatus trans-Golgi network lipid metabolic process sphingolipid metabolic process glucosylceramide catabolic process autophagy lysosome organization metabolic process steroid metabolic process cholesterol metabolic process cellular response to starvation response to pH membrane transferase activity transferase activity, transferring glycosyl groups hydrolase activity hydrolase activity, acting on glycosyl bonds termination of signal transduction lipid glycosylation negative regulation of protein complex assembly regulation of TOR signaling regulation of cellular protein metabolic process negative regulation of cellular protein metabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of protein homooligomerization negative regulation of interleukin-6 production regulation of water loss via skin response to testosterone positive regulation of protein dephosphorylation lysosomal lumen positive regulation of protein complex disassembly negative regulation of MAP kinase activity skin morphogenesis response to estrogen sphingosine biosynthetic process ceramide biosynthetic process glucosyltransferase activity steryl-beta-glucosidase activity regulation of protein metabolic process positive regulation of protein metabolic process cellular response to tumor necrosis factor response to dexamethasone response to thyroid hormone negative regulation of neuron death beta-glucoside catabolic process positive regulation of proteolysis involved in cellular protein catabolic process positive regulation of protein lipidation positive regulation of neuronal action potential positive regulation of mitophagy in response to mitochondrial depolarization autophagosome organization uc008pyc.1 uc008pyc.2 uc008pyc.3 uc008pyc.4 
ENSMUST00000077375.5 Scml2 ENSMUST00000077375.5 Scml2 (from geneSymbol) B1AVB3 B1AVB3_MOUSE BC056382 ENSMUST00000077375.1 ENSMUST00000077375.2 ENSMUST00000077375.3 ENSMUST00000077375.4 Scml2 uc009utz.1 uc009utz.2 uc009utz.3 nuclear chromatin XY body protein binding nucleus regulation of transcription, DNA-templated apoptotic process cellular protein localization histone H2A-K119 monoubiquitination uc009utz.1 uc009utz.2 uc009utz.3 
ENSMUST00000077376.3 Mtrfr ENSMUST00000077376.3 mitochondrial translation release factor in rescue, transcript variant 1 (from RefSeq NM_001134717.2) ENSMUST00000077376.1 ENSMUST00000077376.2 MTRFR_MOUSE Mtrfr NM_001134717 Q3US94 Q80VP5 Q8BYK3 Q9CSJ6 uc008zpn.1 uc008zpn.2 uc008zpn.3 uc008zpn.4 Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue. Interacts (via C-terminus) with MTRES1 (via S4 domain). Associates with mitoribosomal S39 large subunit, peptidyl tRNA and nascent chain. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80VP5-1; Sequence=Displayed; Name=2; IsoId=Q80VP5-2; Sequence=VSP_029604, VSP_029605; The GGQ domain interacts with the peptidyltransferase center (PTC) of the large ribosomal subunit to trigger nascent chain hydrolysis. Methylation of glutamine in the GGQ triplet by HEMK1. Belongs to the prokaryotic/mitochondrial release factor family. In contrast to other members of the family, lacks the regions that come into close contact with the mRNA in the ribosomal A-site and determine the STOP codon specificity, suggesting a loss of codon specificity for translation release factor activity. translation release factor activity mitochondrion mitochondrial large ribosomal subunit translation translational termination uc008zpn.1 uc008zpn.2 uc008zpn.3 uc008zpn.4 
ENSMUST00000077408.8 Bloc1s3 ENSMUST00000077408.8 biogenesis of lysosomal organelles complex-1, subunit 3, transcript variant 1 (from RefSeq NM_177692.4) BL1S3_MOUSE Blos3 ENSMUST00000077408.1 ENSMUST00000077408.2 ENSMUST00000077408.3 ENSMUST00000077408.4 ENSMUST00000077408.5 ENSMUST00000077408.6 ENSMUST00000077408.7 NM_177692 Q5U5M8 Q8C6R4 Q8R0Z3 Rp uc009fma.1 uc009fma.2 uc009fma.3 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Interacts directly with BLOC1S2 (By similarity). Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. Interacts with BLOC1S4, BLOC1S5 and BLOC1S6. Cytoplasm Ubiquitously expressed. Phosphorylated. Note=Defects in Bloc1s3 are the cause of the reduced pigmentation (rp) mutation phenotype, a mouse model for human Hermansky-Pudlak syndrome (HPS). Rp mice are characterized by abnormal melanosomes and display altered expression levels of the proteins of the BLOC-1 complex. Belongs to the BLOC1S3 family. eye development protein binding cytoplasm cytosol blood coagulation anterograde axonal transport protein transmembrane transporter activity transport vesicle platelet activation BLOC-1 complex neuron projection development melanosome transport melanosome organization positive regulation of natural killer cell activation secretion of lysosomal enzymes endosome to melanosome transport response to drug pigmentation developmental pigmentation anterograde synaptic vesicle transport platelet dense granule organization protein transmembrane transport axon cytoplasm uc009fma.1 uc009fma.2 uc009fma.3 
ENSMUST00000077451.14 Rhot1 ENSMUST00000077451.14 ras homolog family member T1, transcript variant 7 (from RefSeq NM_001404128.1) Arht1 ENSMUST00000077451.1 ENSMUST00000077451.10 ENSMUST00000077451.11 ENSMUST00000077451.12 ENSMUST00000077451.13 ENSMUST00000077451.2 ENSMUST00000077451.3 ENSMUST00000077451.4 ENSMUST00000077451.5 ENSMUST00000077451.6 ENSMUST00000077451.7 ENSMUST00000077451.8 ENSMUST00000077451.9 MIRO1_MOUSE NM_001404128 Q3TJB7 Q3UGU4 Q5SYC3 Q5SYC6 Q8BG51 Q8BLW3 Q8BMH1 Q922N0 Q9D2R1 Q9JKB9 uc288asf.1 uc288asf.2 Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Promotes mitochondrial fission during high calcium conditions (By similarity). Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules (By similarity). Interacts with RAP1GDS1 (By similarity). Interacts with ARMCX1 (PubMed:28009275). Found in a complex with KIF5B, OGT, RHOT2 and TRAK1 (By similarity). Mitochondrion outer membrane ; Single-pass type IV membrane protein Note=Colocalizes with MGARP and RHOT2 at the mitochondria. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BG51-1; Sequence=Displayed; Name=2; IsoId=Q8BG51-2; Sequence=VSP_019159; Name=3; IsoId=Q8BG51-3; Sequence=VSP_019160; Name=4; IsoId=Q8BG51-4; Sequence=VSP_019161; Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30 (By similarity). Belongs to the mitochondrial Rho GTPase family. Sequence=AAF64187.1; Type=Erroneous initiation; Evidence=; Sequence=BAC27274.1; Type=Erroneous initiation; Evidence=; Sequence=CAI25296.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding GTPase activity calcium ion binding GTP binding mitochondrion mitochondrial outer membrane mitochondrion organization Rho protein signal transduction regulation of mitochondrion organization membrane integral component of membrane hydrolase activity cellular homeostasis integral component of mitochondrial outer membrane establishment of mitochondrion localization by microtubule attachment metal ion binding regulation of neurotransmitter secretion mitochondrion transport along microtubule mitochondrial outer membrane permeabilization regulation of organelle transport along microtubule uc288asf.1 uc288asf.2 
ENSMUST00000077452.4 Defa38 ENSMUST00000077452.4 defensin, alpha, 38 (from RefSeq NM_001177482.2) Defa38 Defcr-rs1 ENSMUST00000077452.1 ENSMUST00000077452.2 ENSMUST00000077452.3 Gm14851 NM_001177482 Q5ERJ0 Q5ERJ0_MOUSE uc012gar.1 uc012gar.2 uc012gar.3 Secreted innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc012gar.1 uc012gar.2 uc012gar.3 
ENSMUST00000077460.5 Or10p21 ENSMUST00000077460.5 olfactory receptor family 10 subfamily P member 21 (from RefSeq NM_146862.1) ENSMUST00000077460.1 ENSMUST00000077460.2 ENSMUST00000077460.3 ENSMUST00000077460.4 NM_146862 Olfr763 Or10p21 Q8VGC1 Q8VGC1_MOUSE uc007hpg.1 uc007hpg.2 uc007hpg.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hpg.1 uc007hpg.2 uc007hpg.3 
ENSMUST00000077471.5 Or5w13 ENSMUST00000077471.5 olfactory receptor family 5 subfamily W member 13 (from RefSeq NM_146659.3) A2AV48 ENSMUST00000077471.1 ENSMUST00000077471.2 ENSMUST00000077471.3 ENSMUST00000077471.4 NM_146659 Olfr1136 Olfr153 Or5w13 Q0VBI4 Q0VBI4_MOUSE uc008kol.1 uc008kol.2 uc008kol.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC120618.1, BC120620.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kol.1 uc008kol.2 uc008kol.3 
ENSMUST00000077477.12 Stk19 ENSMUST00000077477.12 serine/threonine kinase 19 (from RefSeq NM_019442.3) ENSMUST00000077477.1 ENSMUST00000077477.10 ENSMUST00000077477.11 ENSMUST00000077477.2 ENSMUST00000077477.3 ENSMUST00000077477.4 ENSMUST00000077477.5 ENSMUST00000077477.6 ENSMUST00000077477.7 ENSMUST00000077477.8 ENSMUST00000077477.9 NM_019442 O70347 Q9JHN8 Rp1 STK19_MOUSE Stk19 uc008cdq.1 uc008cdq.2 uc008cdq.3 Inactive serine/threonine-protein kinase. Nucleus Belongs to the STK19 family. nucleotide binding protein serine/threonine kinase activity ATP binding nucleus protein phosphorylation kinase activity phosphorylation nuclear speck transferase activity Ras GTPase binding positive regulation of Ras protein signal transduction uc008cdq.1 uc008cdq.2 uc008cdq.3 
ENSMUST00000077478.8 Vmn2r73 ENSMUST00000077478.8 vomeronasal 2, receptor 73 (from RefSeq NM_001105186.1) D3Z7M3 D3Z7M3_MOUSE ENSMUST00000077478.1 ENSMUST00000077478.2 ENSMUST00000077478.3 ENSMUST00000077478.4 ENSMUST00000077478.5 ENSMUST00000077478.6 ENSMUST00000077478.7 NM_001105186 Vmn2r73 uc012fon.1 uc012fon.2 uc012fon.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012fon.1 uc012fon.2 uc012fon.3 
ENSMUST00000077485.11 Zfp12 ENSMUST00000077485.11 zinc finger protein 12, transcript variant 2 (from RefSeq NM_177681.5) ENSMUST00000077485.1 ENSMUST00000077485.10 ENSMUST00000077485.2 ENSMUST00000077485.3 ENSMUST00000077485.4 ENSMUST00000077485.5 ENSMUST00000077485.6 ENSMUST00000077485.7 ENSMUST00000077485.8 ENSMUST00000077485.9 NM_177681 Q7TSI0 Q8C7Q7 ZNF12_MOUSE Znf12 uc009ajt.1 uc009ajt.2 uc009ajt.3 uc009ajt.4 Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TSI0-1; Sequence=Displayed; Name=2; IsoId=Q7TSI0-2; Sequence=VSP_040336; Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding nucleus nucleoplasm centrosome regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated metal ion binding uc009ajt.1 uc009ajt.2 uc009ajt.3 uc009ajt.4 
ENSMUST00000077502.5 Dqx1 ENSMUST00000077502.5 DEAQ RNA-dependent ATPase (from RefSeq NM_033606.3) DQX1_MOUSE ENSMUST00000077502.1 ENSMUST00000077502.2 ENSMUST00000077502.3 ENSMUST00000077502.4 NM_033606 Q80ZJ5 Q924H9 uc009cmc.1 uc009cmc.2 uc009cmc.3 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q924H9-1; Sequence=Displayed; Name=2; IsoId=Q924H9-2; Sequence=VSP_024473; Ubiquitous. nucleotide binding DNA helicase activity RNA binding helicase activity ATP binding nucleus hydrolase activity ATPase activity DNA duplex unwinding uc009cmc.1 uc009cmc.2 uc009cmc.3 
ENSMUST00000077517.9 Tmem236 ENSMUST00000077517.9 transmembrane protein 236 (from RefSeq NM_001081310.2) A2ARJ3 ENSMUST00000077517.1 ENSMUST00000077517.2 ENSMUST00000077517.3 ENSMUST00000077517.4 ENSMUST00000077517.5 ENSMUST00000077517.6 ENSMUST00000077517.7 ENSMUST00000077517.8 Fam23a NM_001081310 TM236_MOUSE uc008ikj.1 uc008ikj.2 uc008ikj.3 Membrane ; Multi-pass membrane protein Belongs to the TMEM236 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008ikj.1 uc008ikj.2 uc008ikj.3 
ENSMUST00000077524.4 Mab21l2 ENSMUST00000077524.4 Required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning. (from UniProt Q8BPP1) AK053645 ENSMUST00000077524.1 ENSMUST00000077524.2 ENSMUST00000077524.3 MB212_MOUSE Q8BPP1 Q9R1B2 Q9WVF2 uc008prj.1 uc008prj.2 Required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning. Nucleus Cytoplasm Note=Predominantly localizes to the nucleus, with some cytoplasmic localization. Expressed in the adult cerebellum and eye, with lower levels in the adult forebrain (PubMed:10556287). In embryos at 10.5 days post-coitum strongly expressed in the rostral and distal regions of the developing neural retina, with no expression immediately adjacent to the closing optic fissure. Expression is also observed in the dorsal and ventral aspects of the developing forelimb bud and in the developing pharyngeal arches, as well as in the midbrain (PubMed:24906020). Expressed in the developing dorsal midbrain, the posterior portion of the mesencephalon and the retinal primordium of the optic cup. At 10 dpc, expressed in the temporal and nasal aspect of the retina and throughout the length of the dorsal midbrain. At 10.5 dpc this retinal pattern of expression persists, and extraneural sites of expression include the branchial region, limb buds and intestine. Also highly expressed in the alar mesencephalon and the rhombencephalic basal plate from 10.5 dpc to 14.5 dpc, and in the posterior third of the tectum and the presumptive gut wall. Also strongly expressed in the hindbrain, optic vesicle, maxillary and mandible process, paraxial mesoderm, developing digits and the umbilical cord. Belongs to the mab-21 family. eye development nucleus cytoplasm multicellular organism development positive regulation of cell proliferation embryonic body morphogenesis camera-type eye development uc008prj.1 uc008prj.2 
ENSMUST00000077528.7 Klk1b22 ENSMUST00000077528.7 kallikrein 1-related peptidase b22 (from RefSeq NM_010114.2) ENSMUST00000077528.1 ENSMUST00000077528.2 ENSMUST00000077528.3 ENSMUST00000077528.4 ENSMUST00000077528.5 ENSMUST00000077528.6 Gk22 Klk1b22 Klk22 NM_010114 Q540N3 Q540N3_MOUSE uc009goi.1 uc009goi.2 uc009goi.3 This gene encodes the beta subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. The encoded preproprotein undergoes proteolytic processing to generate a functional, mature peptide. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC106155.1, BF302117.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009goi.1 uc009goi.2 uc009goi.3 
ENSMUST00000077530.3 Rdh19 ENSMUST00000077530.3 retinol dehydrogenase 19 (from RefSeq NM_147222.2) ENSMUST00000077530.1 ENSMUST00000077530.2 G5E8H9 G5E8H9_MOUSE NM_147222 Rdh19 uc007hkt.1 uc007hkt.2 Belongs to the short-chain dehydrogenases/reductases (SDR) family. endoplasmic reticulum membrane oxidoreductase activity integral component of organelle membrane intracellular membrane-bounded organelle androsterone dehydrogenase activity androstan-3-alpha,17-beta-diol dehydrogenase activity oxidation-reduction process retinol dehydrogenase activity uc007hkt.1 uc007hkt.2 
ENSMUST00000077548.12 Cttnbp2nl ENSMUST00000077548.12 CTTNBP2 N-terminal like, transcript variant 1 (from RefSeq NM_030249.4) CT2NL_MOUSE ENSMUST00000077548.1 ENSMUST00000077548.10 ENSMUST00000077548.11 ENSMUST00000077548.2 ENSMUST00000077548.3 ENSMUST00000077548.4 ENSMUST00000077548.5 ENSMUST00000077548.6 ENSMUST00000077548.7 ENSMUST00000077548.8 ENSMUST00000077548.9 Kiaa1433 NM_030249 Q6ZPR0 Q8BSV1 Q922L8 Q99LJ0 uc012cvp.1 uc012cvp.2 Regulates lamellipodial actin dynamics in a CTTN-dependent manner. May form homomers (By similarity). May interact with MOB4, PPP2R1A, PPP2CB, STK24, STK25, STK26, STRN4, STRIP1 and STRIP2 (By similarity). Interacts with CTTN/cortactin; this interaction may redistribute CTTN to stress fibers. Cell projection, lamellipodium Cytoplasm, cytoskeleton, stress fiber Predominantly expressed in skin, also detectable in spleen and lung (at protein level). Very low levels, if any, in brain (at protein level). Sequence=BAC98169.1; Type=Erroneous initiation; Evidence=; cytoplasm cytoskeleton protein dephosphorylation actin cytoskeleton negative regulation of transporter activity negative regulation of transmembrane transport protein phosphatase 2A binding uc012cvp.1 uc012cvp.2 
ENSMUST00000077549.7 Prss43 ENSMUST00000077549.7 serine protease 43 (from RefSeq NM_199471.1) ENSMUST00000077549.1 ENSMUST00000077549.2 ENSMUST00000077549.3 ENSMUST00000077549.4 ENSMUST00000077549.5 ENSMUST00000077549.6 NM_199471 PRS43_MOUSE Prss43 Q76HL1 Tessp3 uc009ruv.1 uc009ruv.2 uc009ruv.3 uc009ruv.4 Plays a role in spermatogenesis. Involved in germ cell survival during meiosis. Lacks protease activity in vitro. Cell membrane ; Lipid-anchor, GPI-anchor Testis-specific (PubMed:23536369). Expressed in germ cells at the stages from late pachytene spermatocytes to spermatids (PubMed:23536369). In testis, expressed at all stages from the late pachytene primary spermatocyte to the secondary spermatocyte. Not detected at day 7 after birth. Expression is detected at day 14 and increases dramatically at day 21 and reach a peak at day 28 to remain high until day 56. Belongs to the peptidase S1 family. Lacks protease activity in vitro. serine-type endopeptidase activity extracellular space plasma membrane proteolysis germ cell development spermatogenesis peptidase activity membrane integral component of membrane hydrolase activity cell differentiation anchored component of membrane anchored component of plasma membrane uc009ruv.1 uc009ruv.2 uc009ruv.3 uc009ruv.4 
ENSMUST00000077577.8 Tuba1b ENSMUST00000077577.8 tubulin, alpha 1B (from RefSeq NM_011654.2) ENSMUST00000077577.1 ENSMUST00000077577.2 ENSMUST00000077577.3 ENSMUST00000077577.4 ENSMUST00000077577.5 ENSMUST00000077577.6 ENSMUST00000077577.7 NM_011654 P05213 Q3TY23 Q3U8B1 Q3UAW8 Q4KMW2 TBA1B_MOUSE Tuba2 uc007xoj.1 uc007xoj.2 uc007xoj.3 uc007xoj.4 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Nascent tubulin polypeptide interacts (via beta- tubulin MREC motif) with TTC5/STRAP; this interaction may result in tubulin mRNA-targeted degradation. Cytoplasm, cytoskeleton. Ubiquitously expressed with highest levels in spleen, thymus and immature brain. The MREC motif mediates interaction with TTC5/STRAP and may be critical for tubulin autoregulation. Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility (PubMed:33414192). Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:1967194, PubMed:15890843). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (PubMed:23897886). Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly. Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability. Nitration of Tyr-451 is irreversible and interferes with normal dynein intracellular distribution. Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (MATCAP, VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively. [Tubulin alpha-1B chain]: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (PubMed:16954346, PubMed:19564401). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules. In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity). [Detyrosinated tubulin alpha-1B chain]: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (By similarity). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle (PubMed:26446751). In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (PubMed:27102488). Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle double-stranded RNA binding GTPase activity structural constituent of cytoskeleton protein binding GTP binding cytoplasm cytosol cytoskeleton microtubule cytoplasmic microtubule microtubule-based process microtubule cytoskeleton ubiquitin protein ligase binding myelin sheath membrane raft cellular response to interleukin-4 uc007xoj.1 uc007xoj.2 uc007xoj.3 uc007xoj.4 
ENSMUST00000077626.13 Pigu ENSMUST00000077626.13 phosphatidylinositol glycan anchor biosynthesis, class U (from RefSeq NM_001004721.1) Cdc91l1 ENSMUST00000077626.1 ENSMUST00000077626.10 ENSMUST00000077626.11 ENSMUST00000077626.12 ENSMUST00000077626.2 ENSMUST00000077626.3 ENSMUST00000077626.4 ENSMUST00000077626.5 ENSMUST00000077626.6 ENSMUST00000077626.7 ENSMUST00000077626.8 ENSMUST00000077626.9 NM_001004721 Pigu Q3TAA8 Q3TAA8_MOUSE uc008nki.1 uc008nki.2 uc008nki.3 Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the PIGU family. GPI-anchor transamidase activity plasma membrane GPI anchor biosynthetic process membrane integral component of membrane attachment of GPI anchor to protein GPI anchor binding GPI-anchor transamidase complex regulation of JAK-STAT cascade uc008nki.1 uc008nki.2 uc008nki.3 
ENSMUST00000077639.7 Cyp4f37 ENSMUST00000077639.7 cytochrome P450, family 4, subfamily f, polypeptide 37 (from RefSeq NM_001100187.1) 677156 Cyp4f16 Cyp4f37 EG623748 ENSMUST00000077639.1 ENSMUST00000077639.2 ENSMUST00000077639.3 ENSMUST00000077639.4 ENSMUST00000077639.5 ENSMUST00000077639.6 Gm9705 NM_001100187 Q3V1F1 Q3V1F1_MOUSE uc008bxj.1 uc008bxj.2 uc008bxj.3 Belongs to the cytochrome P450 family. molecular_function monooxygenase activity iron ion binding cellular_component oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc008bxj.1 uc008bxj.2 uc008bxj.3 
ENSMUST00000077667.4 Obp2a ENSMUST00000077667.4 odorant binding protein 2A (from RefSeq NM_153558.1) ENSMUST00000077667.1 ENSMUST00000077667.2 ENSMUST00000077667.3 Lcn13 NM_153558 OBP2A_MOUSE Q8K1H9 uc008itf.1 uc008itf.2 uc008itf.3 Involved in the regulation of systematic glucose homeostasis and insulin sensitivity (PubMed:27827363). Involved in the regulation of liver lipid levels by positive regulation of hepatic lipogenesis and negative regulation of fatty acid beta-oxidation; via downstream transcriptional regulation of CPT1A and hepatic lipogenic program gene expression (PubMed:21908604). May regulate hepatic lipogenesis and fatty acid beta-oxidation in an autocrine or paracrine manner (PubMed:21908604). Secreted Expressed in the liver (at protein level) (PubMed:21908604, PubMed:27827363). Expressed in epididymis (PubMed:15363845). Expressed in the epididymis from 3 weeks of age. May be involved in the development of hepatic steatosis during obesity. Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component extracellular region biological_process small molecule binding uc008itf.1 uc008itf.2 uc008itf.3 
ENSMUST00000077680.10 Tfe3 ENSMUST00000077680.10 transcription factor E3, transcript variant 1 (from RefSeq NM_172472.3) A2AEW1 A2AEW1_MOUSE ENSMUST00000077680.1 ENSMUST00000077680.2 ENSMUST00000077680.3 ENSMUST00000077680.4 ENSMUST00000077680.5 ENSMUST00000077680.6 ENSMUST00000077680.7 ENSMUST00000077680.8 ENSMUST00000077680.9 NM_172472 Tfe3 uc009smh.1 uc009smh.2 uc009smh.3 uc009smh.4 Nucleus Belongs to the MiT/TFE family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated humoral immune response regulation of osteoclast differentiation positive regulation of cell adhesion positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity uc009smh.1 uc009smh.2 uc009smh.3 uc009smh.4 
ENSMUST00000077693.10 Eif2b4 ENSMUST00000077693.10 eukaryotic translation initiation factor 2B, subunit 4 delta, transcript variant 2 (from RefSeq NM_010122.2) EI2BD_MOUSE ENSMUST00000077693.1 ENSMUST00000077693.2 ENSMUST00000077693.3 ENSMUST00000077693.4 ENSMUST00000077693.5 ENSMUST00000077693.6 ENSMUST00000077693.7 ENSMUST00000077693.8 ENSMUST00000077693.9 Eif2b Eif2bd Jgr1a NM_010122 Q3TYW7 Q61748 Q61749 Q8VC35 uc008wxl.1 uc008wxl.2 uc008wxl.3 uc008wxl.4 Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. Activated by the chemical integrated stress response (ISR) inhibitor ISRIB which stimulates guanine nucleotide exchange factor activity for both phosphorylated and unphosphorylated eIF2. Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61749-1; Sequence=Displayed; Name=2; IsoId=Q61749-2; Sequence=VSP_001434; Belongs to the eIF-2B alpha/beta/delta subunits family. ovarian follicle development translation initiation factor activity guanyl-nucleotide exchange factor activity cytoplasm eukaryotic translation initiation factor 2B complex translation translational initiation response to heat response to glucose oligodendrocyte development translation initiation factor binding myelination response to peptide hormone cellular metabolic process T cell receptor signaling pathway negative regulation of guanyl-nucleotide exchange factor activity uc008wxl.1 uc008wxl.2 uc008wxl.3 uc008wxl.4 
ENSMUST00000077698.5 Calml3 ENSMUST00000077698.5 calmodulin-like 3 (from RefSeq NM_027416.3) CALL3_MOUSE ENSMUST00000077698.1 ENSMUST00000077698.2 ENSMUST00000077698.3 ENSMUST00000077698.4 NM_027416 Q99K52 Q9D6P8 uc007pja.1 uc007pja.2 uc007pja.3 uc007pja.4 May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates (By similarity). Interacts with MYO10, the interaction is calcium-dependent and essential for MYO10 function in filopodial extension. Binds four calcium ions. Belongs to the calmodulin family. calcium ion binding calcium-mediated signaling metal ion binding uc007pja.1 uc007pja.2 uc007pja.3 uc007pja.4 
ENSMUST00000077709.11 Tmem268 ENSMUST00000077709.11 transmembrane protein 268, transcript variant 1 (from RefSeq NM_001356355.1) ENSMUST00000077709.1 ENSMUST00000077709.10 ENSMUST00000077709.2 ENSMUST00000077709.3 ENSMUST00000077709.4 ENSMUST00000077709.5 ENSMUST00000077709.6 ENSMUST00000077709.7 ENSMUST00000077709.8 ENSMUST00000077709.9 NM_001356355 Q3TTV3 Q3UMC5 Q80VW1 Q80VW2 Q8BMN2 Q8C0I7 Q8CIJ7 Q8R239 TM268_MOUSE Tmem268 uc008tgt.1 uc008tgt.2 uc008tgt.3 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R239-1; Sequence=Displayed; Name=2; IsoId=Q8R239-2; Sequence=VSP_023429, VSP_023430; Name=3; IsoId=Q8R239-3; Sequence=VSP_023428; Sequence=AAH23748.1; Type=Frameshift; Evidence=; Sequence=CAD62270.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAD62271.1; Type=Erroneous gene model prediction; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008tgt.1 uc008tgt.2 uc008tgt.3 
ENSMUST00000077715.6 Krtap19-9b ENSMUST00000077715.6 keratin associated protein 19-9B (from RefSeq NM_133359.2) ENSMUST00000077715.1 ENSMUST00000077715.2 ENSMUST00000077715.3 ENSMUST00000077715.4 ENSMUST00000077715.5 K199B_MOUSE Krtap16-10b Krtap16.10L NM_133359 Q80VT9 Q99NG9 uc007zvm.1 uc007zvm.2 uc007zvm.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Expression in skin and hair follicle is regulated by HOXC13 and by GATA3. Belongs to the KRTAP type 19 family. molecular_function cellular_component intermediate filament biological_process uc007zvm.1 uc007zvm.2 uc007zvm.3 
ENSMUST00000077719.4 Mup21 ENSMUST00000077719.4 major urinary protein 21 (from RefSeq NM_001009550.2) ENSMUST00000077719.1 ENSMUST00000077719.2 ENSMUST00000077719.3 Mup21 Mup26 NM_001009550 OTTMUSG00000000231 Q80YX8 Q80YX8_MOUSE uc008tbv.1 uc008tbv.2 uc008tbv.3 uc008tbv.4 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc008tbv.1 uc008tbv.2 uc008tbv.3 uc008tbv.4 
ENSMUST00000077730.7 Pik3c2b ENSMUST00000077730.7 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta (from RefSeq NM_001099276.2) E9QAN8 E9QAN8_MOUSE ENSMUST00000077730.1 ENSMUST00000077730.2 ENSMUST00000077730.3 ENSMUST00000077730.4 ENSMUST00000077730.5 ENSMUST00000077730.6 NM_001099276 Pik3c2b uc011wry.1 uc011wry.2 uc011wry.3 Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:18373, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57658, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216; EC=2.7.1.154; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18374; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+); Xref=Rhea:RHEA:12709, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088, ChEBI:CHEBI:456216; EC=2.7.1.137; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12710; Evidence=; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. lipid kinase activity protein binding nucleoplasm cytoplasm cytosol plasma membrane phosphatidylinositol 3-kinase complex cellular response to starvation phosphatidylinositol 3-kinase signaling membrane macroautophagy kinase activity 1-phosphatidylinositol-3-kinase activity phosphorylation transferase activity endocytic vesicle 1-phosphatidylinositol-4-phosphate 3-kinase activity phosphatidylinositol binding phosphatidylinositol-3-phosphate biosynthetic process protein kinase B signaling phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling autophagosome organization uc011wry.1 uc011wry.2 uc011wry.3 
ENSMUST00000077737.13 Brd3 ENSMUST00000077737.13 bromodomain containing 3, transcript variant 2 (from RefSeq NM_001113573.1) BRD3_MOUSE ENSMUST00000077737.1 ENSMUST00000077737.10 ENSMUST00000077737.11 ENSMUST00000077737.12 ENSMUST00000077737.2 ENSMUST00000077737.3 ENSMUST00000077737.4 ENSMUST00000077737.5 ENSMUST00000077737.6 ENSMUST00000077737.7 ENSMUST00000077737.8 ENSMUST00000077737.9 Fsrg2 NM_001113573 Q8C665 Q8CAX7 Q8K2F0 Q9JI25 uc008ixn.1 uc008ixn.2 uc008ixn.3 uc008ixn.4 Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:21536911). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (PubMed:21536911). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro) (PubMed:21536911). Interacts (via bromo domain 1) with GATA1 acetylated at 'Lys-312' and 'Lys-315' (PubMed:21555453). Interacts (via bromo domain 1) with GATA2 acetylated on lysine residues (PubMed:21555453). Nucleus Note=Detected on chromatin. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2F0-1; Sequence=Displayed; Name=2; IsoId=Q8K2F0-2; Sequence=VSP_010249; The Bromo domains specifically recognize and bind acetylated histones. chromatin binding cellular_component nucleus chromatin organization regulation of transcription from RNA polymerase II promoter lysine-acetylated histone binding uc008ixn.1 uc008ixn.2 uc008ixn.3 uc008ixn.4 
ENSMUST00000077741.12 Slc9a6 ENSMUST00000077741.12 solute carrier family 9 (sodium/hydrogen exchanger), member 6, transcript variant 1 (from RefSeq NM_172780.5) A1L3P4 ENSMUST00000077741.1 ENSMUST00000077741.10 ENSMUST00000077741.11 ENSMUST00000077741.2 ENSMUST00000077741.3 ENSMUST00000077741.4 ENSMUST00000077741.5 ENSMUST00000077741.6 ENSMUST00000077741.7 ENSMUST00000077741.8 ENSMUST00000077741.9 NM_172780 Nhe6 Q8BTG0 SL9A6_MOUSE uc009tgk.1 uc009tgk.2 uc009tgk.3 uc009tgk.4 Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (PubMed:17005858, PubMed:21413028, PubMed:24035762, PubMed:34526390). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (PubMed:21413028, PubMed:34526390). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (By similarity). Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (PubMed:17005858, PubMed:21413028). Reaction=H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out); Xref=Rhea:RHEA:29419, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101; Evidence=; Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out); Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103; Evidence=; Homodimer. Interacts with RACK1; regulates the distribution of SLC9A6 between endosomes and the plasma membrane. Endosome membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Present predominantly in the recycling compartments including early and recycling endosomes, but undergoes plasma membrane localization during vesicular recycling, which is enhanced upon certain stimuli, such as hypoxia. Developmentally regulated in area CA1 of the hippocamus, peaking at around postnatal day 50 and declining thereafter. Ubiquitinated (in vitro). Glycosylated. The SLC9A6 null mice show a 10-20% increased mortality after birth, yet the surviving mice do not display any obvious difference. Behavioral tests reveal a modest motor hyperactivity associated with coordination deficits and limited ataxia. Neurons from these deficient mice exhibit endosomal hyperacidification, as well as impoverished neuronal arborization and attendant circuit dysfunction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. mitochondrion endosome early endosome late endosome endoplasmic reticulum membrane plasma membrane ion transport cation transport sodium ion transport regulation of pH antiporter activity solute:proton antiporter activity sodium:proton antiporter activity potassium:proton antiporter activity membrane integral component of membrane dendrite cytoplasmic vesicle brain-derived neurotrophic factor receptor signaling pathway early endosome membrane intracellular membrane-bounded organelle axon terminus axonal spine synapse axon extension neuron projection morphogenesis synapse organization regulation of neurotrophin TRK receptor signaling pathway regulation of intracellular pH recycling endosome recycling endosome membrane transmembrane transport dendritic spine development potassium ion transmembrane transport dendrite extension anion transmembrane transport sodium ion import across plasma membrane hydrogen ion transmembrane transport uc009tgk.1 uc009tgk.2 uc009tgk.3 uc009tgk.4 
ENSMUST00000077755.11 Arpc5 ENSMUST00000077755.11 actin related protein 2/3 complex, subunit 5 (from RefSeq NM_026369.2) ARPC5_MOUSE ENSMUST00000077755.1 ENSMUST00000077755.10 ENSMUST00000077755.2 ENSMUST00000077755.3 ENSMUST00000077755.4 ENSMUST00000077755.5 ENSMUST00000077755.6 ENSMUST00000077755.7 ENSMUST00000077755.8 ENSMUST00000077755.9 NM_026369 Q3U9T3 Q9CPW4 Q9D8E7 uc007czj.1 uc007czj.2 uc007czj.3 uc007czj.4 Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Cytoplasm, cytoskeleton Cell projection Nucleus Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation. Belongs to the ARPC5 family. actin binding structural constituent of cytoskeleton nucleus cytoplasm endosome cytoskeleton Arp2/3 protein complex smooth muscle cell migration actin cytoskeleton cell migration orbitofrontal cortex development maintenance of cell polarity lamellipodium growth cone regulation of actin filament polymerization Arp2/3 complex-mediated actin nucleation site of double-strand break cell projection neuron projection actin filament binding actin filament network formation lamellipodium organization uc007czj.1 uc007czj.2 uc007czj.3 uc007czj.4 
ENSMUST00000077757.7 Or8g20 ENSMUST00000077757.7 olfactory receptor family 8 subfamily G member 20 (from RefSeq NM_146830.2) ENSMUST00000077757.1 ENSMUST00000077757.2 ENSMUST00000077757.3 ENSMUST00000077757.4 ENSMUST00000077757.5 ENSMUST00000077757.6 NM_146830 Olfr44 Or8g20 Q9EQB8 Q9EQB8_MOUSE uc009oya.1 uc009oya.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB173575.1, CB174038.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oya.1 uc009oya.2 
ENSMUST00000077772.12 Sag ENSMUST00000077772.12 S-antigen, retina and pineal gland (arrestin) (from RefSeq NM_009118.2) ENSMUST00000077772.1 ENSMUST00000077772.10 ENSMUST00000077772.11 ENSMUST00000077772.2 ENSMUST00000077772.3 ENSMUST00000077772.4 ENSMUST00000077772.5 ENSMUST00000077772.6 ENSMUST00000077772.7 ENSMUST00000077772.8 ENSMUST00000077772.9 NM_009118 Q3UPX6 Q3UPX6_MOUSE Sag uc007bxs.1 uc007bxs.2 uc007bxs.3 Cell projection, cilium, photoreceptor outer segment Belongs to the arrestin family. photoreceptor outer segment signal transduction uc007bxs.1 uc007bxs.2 uc007bxs.3 
ENSMUST00000077775.11 Xpnpep2 ENSMUST00000077775.11 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound, transcript variant 1 (from RefSeq NM_133213.2) B1AVD1 ENSMUST00000077775.1 ENSMUST00000077775.10 ENSMUST00000077775.2 ENSMUST00000077775.3 ENSMUST00000077775.4 ENSMUST00000077775.5 ENSMUST00000077775.6 ENSMUST00000077775.7 ENSMUST00000077775.8 ENSMUST00000077775.9 NM_133213 Q3TA51 Q3TPA9 Q8BVD6 Q91Y31 Q91ZH9 XPP2_MOUSE Xpnpep2 uc009tbv.1 uc009tbv.2 Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin. Reaction=Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.; EC=3.4.11.9; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Homotrimer. Cell membrane ; Lipid-anchor, GPI-anchor Strongly expressed in small intestine, heart and lung. Also detected in testis, skeletal muscle, spleen, liver, kidney, brain, uterus, eye, lymph node, thymus, stomach, prostate and bone marrow. Expressed in embryos from 7 days onwards, with highest expression at 15 days. N-glycosylated. Belongs to the peptidase M24B family. Sequence=BAC37415.1; Type=Frameshift; Evidence=; Sequence=BAE37828.1; Type=Frameshift; Evidence=; Sequence=BAE42819.1; Type=Frameshift; Evidence=; aminopeptidase activity cytoplasm plasma membrane proteolysis biological_process peptidase activity membrane hydrolase activity anchored component of membrane metal ion binding metalloaminopeptidase activity extracellular exosome uc009tbv.1 uc009tbv.2 
ENSMUST00000077780.14 Zfp61 ENSMUST00000077780.14 zinc finger protein 61 (from RefSeq NM_009561.2) ENSMUST00000077780.1 ENSMUST00000077780.10 ENSMUST00000077780.11 ENSMUST00000077780.12 ENSMUST00000077780.13 ENSMUST00000077780.2 ENSMUST00000077780.3 ENSMUST00000077780.4 ENSMUST00000077780.5 ENSMUST00000077780.6 ENSMUST00000077780.7 ENSMUST00000077780.8 ENSMUST00000077780.9 NM_009561 Q923D1 Q923D1_MOUSE Zfp61 uc009fpf.1 uc009fpf.2 uc009fpf.3 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc009fpf.1 uc009fpf.2 uc009fpf.3 
ENSMUST00000077783.5 0610030E20Rik ENSMUST00000077783.5 RIKEN cDNA 0610030E20 gene (from RefSeq NM_026696.1) CB068_MOUSE ENSMUST00000077783.1 ENSMUST00000077783.2 ENSMUST00000077783.3 ENSMUST00000077783.4 NM_026696 Q149G0 Q9DCK6 uc009cig.1 uc009cig.2 uc009cig.3 uc009cig.4 uc009cig.5 Belongs to the UPF0561 family. Sequence=BAB22295.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc009cig.1 uc009cig.2 uc009cig.3 uc009cig.4 uc009cig.5 
ENSMUST00000077788.7 Tnfaip8l1 ENSMUST00000077788.7 tumor necrosis factor, alpha-induced protein 8-like 1 (from RefSeq NM_025566.3) ENSMUST00000077788.1 ENSMUST00000077788.2 ENSMUST00000077788.3 ENSMUST00000077788.4 ENSMUST00000077788.5 ENSMUST00000077788.6 NM_025566 Q3U6E5 Q8K288 Q9D0N6 Q9DBH7 TP8L1_MOUSE uc008dbf.1 uc008dbf.2 uc008dbf.3 uc008dbf.4 Acts as a negative regulator of mTOR activity. Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination. Cytoplasm Detected in wide variety tissues, such as neurons in brain, hepatocytes, germ cells of female and male reproductive organs, muscular tissues and variety types of cells of the epithelial origin (at protein level). Up-regulated by oxidative stress and by 6-hydroxydopamine (6-OHDA) in dopaminergic neurons. Belongs to the TNFAIP8 family. protein binding cytoplasm negative regulation of TOR signaling regulation of apoptotic process uc008dbf.1 uc008dbf.2 uc008dbf.3 uc008dbf.4 
ENSMUST00000077791.8 Zfp1 ENSMUST00000077791.8 zinc finger protein 1, transcript variant 1 (from RefSeq NM_001037665.2) ENSMUST00000077791.1 ENSMUST00000077791.2 ENSMUST00000077791.3 ENSMUST00000077791.4 ENSMUST00000077791.5 ENSMUST00000077791.6 ENSMUST00000077791.7 NM_001037665 Q3UI68 Q3UI68_MOUSE Zfp1 uc009nmo.1 uc009nmo.2 uc009nmo.3 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009nmo.1 uc009nmo.2 uc009nmo.3 
ENSMUST00000077798.13 Ssrp1 ENSMUST00000077798.13 structure specific recognition protein 1, transcript variant 1 (from RefSeq NM_182990.5) ENSMUST00000077798.1 ENSMUST00000077798.10 ENSMUST00000077798.11 ENSMUST00000077798.12 ENSMUST00000077798.2 ENSMUST00000077798.3 ENSMUST00000077798.4 ENSMUST00000077798.5 ENSMUST00000077798.6 ENSMUST00000077798.7 ENSMUST00000077798.8 ENSMUST00000077798.9 NM_182990 Q08943 Q3U9Z2 Q3UJ75 Q4V9U4 Q8CGA6 SSRP1_MOUSE uc008kju.1 uc008kju.2 uc008kju.3 uc008kju.4 Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double- stranded DNA. Also acts as a transcriptional coactivator for p63/TP63. Interacts with MYOG (via C-terminal region) (PubMed:23364797). Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H. Also a component of a CK2-SPT16-SSRP1 complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B. Binds to histone H3-H4 tetramers, but not to intact nucleosomes. Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1. Interacts with isoform gamma of TP63. Interacts with FYTTD1/UIF (By similarity). Interacts with SRF (By similarity). Interacts with NEK9 (By similarity). Nucleus Chromosome Nucleus, nucleolus Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q08943-1; Sequence=Displayed; Name=2; IsoId=Q08943-2; Sequence=VSP_019626; Phosphorylated by CK2 following UV but not gamma irradiation. Phosphorylation inhibits its DNA-binding activity (By similarity). Ubiquitinated. Polyubiquitinated following caspase cleavage resulting in degradation of the N-terminal ubiquitinated part of the cleaved protein (By similarity). Sumoylated. Embryos die soon after implantation while preimplantation blastocysts are defective for cell outgrowth. Belongs to the SSRP1 family. Sequence=AAH42502.1; Type=Frameshift; Evidence=; nuclear chromatin DNA binding chromatin binding nucleus chromosome nucleolus DNA replication DNA repair cellular response to DNA damage stimulus nucleosome binding FACT complex histone binding uc008kju.1 uc008kju.2 uc008kju.3 uc008kju.4 
ENSMUST00000077821.10 Arhgap39 ENSMUST00000077821.10 Rho GTPase activating protein 39, transcript variant 5 (from RefSeq NM_001416283.1) Arhgap39 ENSMUST00000077821.1 ENSMUST00000077821.2 ENSMUST00000077821.3 ENSMUST00000077821.4 ENSMUST00000077821.5 ENSMUST00000077821.6 ENSMUST00000077821.7 ENSMUST00000077821.8 ENSMUST00000077821.9 H7BX46 H7BX46_MOUSE NM_001416283 uc007wmi.1 uc007wmi.2 uc007wmi.3 cytoskeleton signal transduction uc007wmi.1 uc007wmi.2 uc007wmi.3 
ENSMUST00000077839.13 Nrbf2 ENSMUST00000077839.13 nuclear receptor binding factor 2, transcript variant 3 (from RefSeq NM_001402048.1) ENSMUST00000077839.1 ENSMUST00000077839.10 ENSMUST00000077839.11 ENSMUST00000077839.12 ENSMUST00000077839.2 ENSMUST00000077839.3 ENSMUST00000077839.4 ENSMUST00000077839.5 ENSMUST00000077839.6 ENSMUST00000077839.7 ENSMUST00000077839.8 ENSMUST00000077839.9 NM_001402048 NRBF2_MOUSE Q8VCQ3 Q9DCG3 uc007flw.1 uc007flw.2 uc007flw.3 May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity). Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (By similarity). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (PubMed:24849286). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (By similarity). May be involved in autophagosome biogenesis (By similarity). May play a role in neural progenitor cell survival during differentiation (PubMed:18619852). Involved in the induction of starvation-induced autophagy. Modulates ATG14-linked lipid kinase activity of PIK3C3 and stabilzes PI3K complex I (PI3KC3-C1) assembly (PubMed:24849286). May play a role in neural progenitor cell survival during differentiation (PubMed:18619852). Interacts with RRARA, PPARD and PPARG. Interacts with THRB, RARA, RARG and RXRA in the presence of bound ligand (By similarity). Interacts with SCOC (By similarity). Associates with the PI3K complex I (PI3KC3-C1); the direct binding partner in the complex is reported variably as PIK3R4 or ATG14 (PubMed:24849286). Q8VCQ3; Q8CDJ3: Atg14; NbExp=7; IntAct=EBI-2365563, EBI-3506699; Q8VCQ3; O88597: Becn1; NbExp=5; IntAct=EBI-2365563, EBI-643716; Nucleus Cytoplasm Cytoplasmic vesicle, autophagosome During embryonic brain development detected in the cerebral cortex at 14 dpc; expressed in the walls of the third and fourth ventricles, and in the hippocampus. In the adult brain, predominantly expressed in Purkinje cells of the cerebellum and neurons in the CA3 region of the hippocampus (PubMed:18619852). transcription coactivator activity protein binding nucleus transcription factor complex cytoplasm autophagosome regulation of transcription from RNA polymerase II promoter autophagy ligand-dependent nuclear receptor binding cytoplasmic vesicle response to endoplasmic reticulum stress phosphatidylinositol 3-kinase complex, class III regulation of lipid kinase activity positive regulation of nucleic acid-templated transcription uc007flw.1 uc007flw.2 uc007flw.3 
ENSMUST00000077851.10 Kdm4c ENSMUST00000077851.10 lysine (K)-specific demethylase 4C, transcript variant 2 (from RefSeq NM_001172095.1) ENSMUST00000077851.1 ENSMUST00000077851.2 ENSMUST00000077851.3 ENSMUST00000077851.4 ENSMUST00000077851.5 ENSMUST00000077851.6 ENSMUST00000077851.7 ENSMUST00000077851.8 ENSMUST00000077851.9 Jhdm3c Jmjd2c KDM4C_MOUSE Kiaa0780 NM_001172095 Q3UNP7 Q69ZZ5 Q8BUY6 Q8BWA1 Q8VCD7 uc290nif.1 uc290nif.2 Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)- [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60200, Rhea:RHEA- COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961; EC=1.14.11.66; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Nucleus The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity). Belongs to the JHDM3 histone demethylase family. Sequence=BAD32301.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nuclear chromatin blastocyst formation chromatin binding nucleus pericentric heterochromatin chromatin organization chromatin remodeling regulation of transcription from RNA polymerase II promoter zinc ion binding positive regulation of cell proliferation regulation of gene expression positive regulation of gene expression oxidoreductase activity stem cell population maintenance enzyme binding histone demethylase activity histone demethylase activity (H3-K9 specific) histone H3-K9 demethylation histone methyltransferase complex positive regulation of neuron differentiation metal ion binding androgen receptor binding dioxygenase activity histone demethylase activity (H3-K36 specific) oxidation-reduction process histone H3-K36 demethylation negative regulation of histone H3-K9 trimethylation regulation of stem cell differentiation uc290nif.1 uc290nif.2 
ENSMUST00000077853.5 Prpf4b ENSMUST00000077853.5 pre-mRNA processing factor 4B, transcript variant 3 (from RefSeq NR_165079.1) B2RUN6 Cbp143 ENSMUST00000077853.1 ENSMUST00000077853.2 ENSMUST00000077853.3 ENSMUST00000077853.4 NR_165079 O88378 PRP4B_MOUSE Prp4h Prp4k Prp4m Prpk Q61136 Q8BND8 Q8R4Y5 Q9CTL9 Q9CTT0 uc007qbp.1 uc007qbp.2 uc007qbp.3 uc007qbp.4 Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Identified in the spliceosome C complex (By similarity). Interacts with Clk1 C-terminus. Nucleus. Phosphorylated by Clk1. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus spliceosomal complex chromosome mRNA processing protein phosphorylation RNA splicing kinase activity phosphorylation nuclear speck transferase activity catalytic step 2 spliceosome uc007qbp.1 uc007qbp.2 uc007qbp.3 uc007qbp.4 
ENSMUST00000077855.8 Cyp2b19 ENSMUST00000077855.8 cytochrome P450, family 2, subfamily b, polypeptide 19 (from RefSeq NM_007814.2) B2RQK1 CP2BJ_MOUSE ENSMUST00000077855.1 ENSMUST00000077855.2 ENSMUST00000077855.3 ENSMUST00000077855.4 ENSMUST00000077855.5 ENSMUST00000077855.6 ENSMUST00000077855.7 NM_007814 O55071 uc009fut.1 uc009fut.2 uc009fut.3 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Expressed only in differentiated keratinocytes in skin. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding organelle membrane exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc009fut.1 uc009fut.2 uc009fut.3 
ENSMUST00000077856.13 Rpl27 ENSMUST00000077856.13 ribosomal protein L27 (from RefSeq NM_011289.3) ENSMUST00000077856.1 ENSMUST00000077856.10 ENSMUST00000077856.11 ENSMUST00000077856.12 ENSMUST00000077856.2 ENSMUST00000077856.3 ENSMUST00000077856.4 ENSMUST00000077856.5 ENSMUST00000077856.6 ENSMUST00000077856.7 ENSMUST00000077856.8 ENSMUST00000077856.9 NM_011289 Q5BLJ9 Q5BLJ9_MOUSE Rpl27 uc007low.1 uc007low.2 uc007low.3 uc007low.4 Endoplasmic reticulum Rough endoplasmic reticulum Belongs to the eukaryotic ribosomal protein eL27 family. structural constituent of ribosome ribosome rRNA processing translation ribonucleoprotein complex uc007low.1 uc007low.2 uc007low.3 uc007low.4 
ENSMUST00000077879.7 Vps13c ENSMUST00000077879.7 vacuolar protein sorting 13C (from RefSeq NM_177184.4) ENSMUST00000077879.1 ENSMUST00000077879.2 ENSMUST00000077879.3 ENSMUST00000077879.4 ENSMUST00000077879.5 ENSMUST00000077879.6 Kiaa3021 NM_177184 Q3V3W5 Q6ZPE1 Q8BLB1 Q8BQI7 Q8BX70 VP13C_MOUSE Vps13c uc009qms.1 uc009qms.2 uc009qms.3 Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (By similarity). Involved in the regulation of PINK1/PRKN- mediated mitophagy in response to mitochondrial depolarization (By similarity). Mitochondrion outer membrane Lipid droplet Endoplasmic reticulum membrane Lysosome membrane Late endosome membrane Note=May localize to endoplasmic reticulum-endolysosome contact sites. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BX70-1; Sequence=Displayed; Name=2 ; IsoId=Q8BX70-2; Sequence=VSP_052247, VSP_052248; Name=3 ; IsoId=Q8BX70-3; Sequence=VSP_052246; The FFAT motif is required for localization to the endoplasmic reticulum. Belongs to the VPS13 family. Sequence=BAC33451.1; Type=Frameshift; Evidence=; Sequence=BAC33809.1; Type=Erroneous initiation; Evidence=; Sequence=BAE20465.1; Type=Erroneous initiation; Evidence=; molecular_function mitochondrion mitochondrial outer membrane cytosol protein targeting to vacuole mitochondrion organization membrane extrinsic component of membrane protein retention in Golgi apparatus negative regulation of parkin-mediated mitophagy in response to mitochondrial depolarization uc009qms.1 uc009qms.2 uc009qms.3 
ENSMUST00000077916.12 Mlf1 ENSMUST00000077916.12 myeloid leukemia factor 1, transcript variant 2 (from RefSeq NM_010801.3) ENSMUST00000077916.1 ENSMUST00000077916.10 ENSMUST00000077916.11 ENSMUST00000077916.2 ENSMUST00000077916.3 ENSMUST00000077916.4 ENSMUST00000077916.5 ENSMUST00000077916.6 ENSMUST00000077916.7 ENSMUST00000077916.8 ENSMUST00000077916.9 Hls7 MLF1_MOUSE NM_010801 O70217 Q9QWV4 uc008pll.1 uc008pll.2 uc008pll.3 Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. Interacts with CENPU (By similarity). Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP. NRBP1 recruits a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then binds to YWHAZ and is retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2. Binds to COPS3/CSN3 which is required for suppression of COP1 and activation of p53. Q9QWV4; Q99J45: Nrbp1; NbExp=5; IntAct=EBI-354765, EBI-767484; Q9QWV4; P63101: Ywhaz; NbExp=3; IntAct=EBI-354765, EBI-354751; Cytoplasm Nucleus Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Note=Shuttles between the cytoplasm and nucleus. Highly expressed in skeletal muscle, heart, testis. Also found in lung, but not in spleen, thymus, bone marrow, liver and kidney. Expression is activated by FOXJ1. Phosphorylation is required for binding to YWHAZ. Belongs to the MLF family. myeloid progenitor cell differentiation DNA binding protein binding nucleus cytoplasm cytoskeleton cilium transcription, DNA-templated regulation of transcription, DNA-templated cell cycle cell cycle arrest multicellular organism development protein domain specific binding cell differentiation motile cilium ciliary basal body cell projection ciliary base non-motile cilium uc008pll.1 uc008pll.2 uc008pll.3 
ENSMUST00000077918.7 Cfi ENSMUST00000077918.7 complement component factor i, transcript variant 1 (from RefSeq NM_007686.4) B2RWX8 CFAI_MOUSE ENSMUST00000077918.1 ENSMUST00000077918.2 ENSMUST00000077918.3 ENSMUST00000077918.4 ENSMUST00000077918.5 ENSMUST00000077918.6 If NM_007686 Q61129 Q9WU07 uc008rin.1 uc008rin.2 uc008rin.3 This gene encodes a serine protease that plays an important role in the classical and alternative complement pathways where it cleaves C4b and C3b components of C3 and C5 convertases. The encoded preproprotein undergoes proteolytic processing to generate an active, disulfide-linked heterodimeric enzyme comprised of heavy and light chains. [provided by RefSeq, Jul 2016]. Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha- chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization. Reaction=Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.; EC=3.4.21.45; Heterodimer of a light and heavy chains; disulfide-linked. The fully processed and mature protein circulates as a zymogen, and is allosterically activated by substrate-induced remodeling of the active site. Interacts with C3b. Interacts with complement factor H. Secreted, extracellular space Expressed in the liver by hepatocytes. Also present in other cells such as monocytes, fibroblasts or keratinocytes. CFI-deficient mice are viable and fertile under specific pathogen-free conditions. In the absence of factor I/CFI, physiological cleavage of the alpha-chain of C3b is prevented, and reduced plasma C3, factor B, and factor H levels are observed. Belongs to the peptidase S1 family. immune system process serine-type endopeptidase activity scavenger receptor activity extracellular region extracellular space nucleus proteolysis endocytosis complement activation, classical pathway peptidase activity serine-type peptidase activity membrane hydrolase activity innate immune response metal ion binding uc008rin.1 uc008rin.2 uc008rin.3 
ENSMUST00000077925.7 Unc5b ENSMUST00000077925.7 unc-5 netrin receptor B, transcript variant 1 (from RefSeq NM_029770.3) ENSMUST00000077925.1 ENSMUST00000077925.2 ENSMUST00000077925.3 ENSMUST00000077925.4 ENSMUST00000077925.5 ENSMUST00000077925.6 NM_029770 Q3U4F2 Q6PFH0 Q80Y85 Q8K1S3 Q9D398 UNC5B_MOUSE Unc5h2 uc007ffe.1 uc007ffe.2 uc007ffe.3 Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as a netrin receptor that negatively regulates vascular branching during angiogenesis (PubMed:15510105). Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (PubMed:15510105). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity). Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic part. Interacts (via death domain) with DAPK1 (via death domain) (By similarity). Interacts (via extracellular domain) with FLRT2 and FLRT3 (via extracellular domain), but has higher affinity for FLRT3 (PubMed:19492039, PubMed:21673655, PubMed:22405201, PubMed:25374360). Identified in a complex with FLRT3 and ADGRL3; does not interact with ADGRL3 by itself (By similarity). Q8K1S3; Q7TNP2: Ppp2r1b; NbExp=2; IntAct=EBI-4396886, EBI-4396871; Q8K1S3-1; O09118: Ntn1; NbExp=4; IntAct=EBI-11658250, EBI-1798844; Cell membrane ingle-pass type I membrane protein Membrane raft Note=Associated with lipid rafts. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K1S3-1; Sequence=Displayed; Name=2; IsoId=Q8K1S3-2; Sequence=VSP_011699; Highly expressed in brain. Expressed in lung during late development. Expressed during early blood vessel formation, in the semicircular canal and in a dorsal to ventral gradient in the retina. Phosphorylated on cytoplasmic tyrosine residues. Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts. Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. Complete embryonic lethality, due to defects in blood vessel development that lead to heart failure. Mutant embryos display increased branching of the internal carotid artery and of blood vessels in the nervous system, including thinner and more highly branched brain capillaries. Endothelial tip cells present an increased number of filopodia. Belongs to the unc-5 family. Sequence=AAH48162.1; Type=Erroneous initiation; Evidence=; angiogenesis netrin receptor activity protein binding cytosol plasma membrane apoptotic process signal transduction multicellular organism development axon guidance positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane anterior/posterior axon guidance netrin-activated signaling pathway negative regulation of neuron apoptotic process membrane raft negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of extrinsic apoptotic signaling pathway in absence of ligand uc007ffe.1 uc007ffe.2 uc007ffe.3 
ENSMUST00000077938.10 Haghl ENSMUST00000077938.10 hydroxyacylglutathione hydrolase-like, transcript variant 9 (from RefSeq NM_001378782.1) ENSMUST00000077938.1 ENSMUST00000077938.2 ENSMUST00000077938.3 ENSMUST00000077938.4 ENSMUST00000077938.5 ENSMUST00000077938.6 ENSMUST00000077938.7 ENSMUST00000077938.8 ENSMUST00000077938.9 HAGHL_MOUSE NM_001378782 Q8C8C4 Q9DB32 uc008bbs.1 uc008bbs.2 uc008bbs.3 uc008bbs.4 Hydrolase acting on ester bonds. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DB32-1; Sequence=Displayed; Name=2; IsoId=Q9DB32-2; Sequence=VSP_030057, VSP_030058; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. molecular_function hydroxyacylglutathione hydrolase activity cellular_component biological_process hydrolase activity methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione metal ion binding uc008bbs.1 uc008bbs.2 uc008bbs.3 uc008bbs.4 
ENSMUST00000077954.13 Sgcg ENSMUST00000077954.13 sarcoglycan, gamma (dystrophin-associated glycoprotein) (from RefSeq NM_011892.3) ENSMUST00000077954.1 ENSMUST00000077954.10 ENSMUST00000077954.11 ENSMUST00000077954.12 ENSMUST00000077954.2 ENSMUST00000077954.3 ENSMUST00000077954.4 ENSMUST00000077954.5 ENSMUST00000077954.6 ENSMUST00000077954.7 ENSMUST00000077954.8 ENSMUST00000077954.9 NM_011892 Q9EQ83 Q9EQ83_MOUSE Sgcg uc007ufs.1 uc007ufs.2 Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Cell membrane, sarcolemma ; Single-pass type II membrane protein Belongs to the sarcoglycan beta/delta/gamma/zeta family. nucleoplasm sarcoglycan complex membrane integral component of membrane uc007ufs.1 uc007ufs.2 
ENSMUST00000077955.6 Ccdc102a ENSMUST00000077955.6 coiled-coil domain containing 102A (from RefSeq NM_001033533.3) A0AUL1 C102A_MOUSE ENSMUST00000077955.1 ENSMUST00000077955.2 ENSMUST00000077955.3 ENSMUST00000077955.4 ENSMUST00000077955.5 NM_001033533 Q3B7Y4 Q3TMW1 uc009mxh.1 uc009mxh.2 uc009mxh.3 molecular_function motor activity cellular_component biological_process myosin complex uc009mxh.1 uc009mxh.2 uc009mxh.3 
ENSMUST00000077960.7 H2-T22 ENSMUST00000077960.7 histocompatibility 2, T region locus 22, transcript variant 4 (from RefSeq NM_001359755.2) ENSMUST00000077960.1 ENSMUST00000077960.2 ENSMUST00000077960.3 ENSMUST00000077960.4 ENSMUST00000077960.5 ENSMUST00000077960.6 H2-T22 NM_001359755 Q31615 Q31615_MOUSE uc008cju.1 uc008cju.2 uc008cju.3 uc008cju.4 Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc008cju.1 uc008cju.2 uc008cju.3 uc008cju.4 
ENSMUST00000077962.8 Kcng2 ENSMUST00000077962.8 potassium voltage-gated channel, subfamily G, member 2, transcript variant 3 (from RefSeq NM_001404105.1) ENSMUST00000077962.1 ENSMUST00000077962.2 ENSMUST00000077962.3 ENSMUST00000077962.4 ENSMUST00000077962.5 ENSMUST00000077962.6 ENSMUST00000077962.7 F7A6P6 F7A6P6_MOUSE Kcng2 NM_001404105 uc012bfj.1 uc012bfj.2 uc012bfj.3 Membrane ; Multi- pass membrane protein ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane regulation of ion transmembrane transport protein homooligomerization transmembrane transport potassium ion transmembrane transport uc012bfj.1 uc012bfj.2 uc012bfj.3 
ENSMUST00000077972.11 Osbpl6 ENSMUST00000077972.11 oxysterol binding protein-like 6, transcript variant 1 (from RefSeq NM_145525.3) ENSMUST00000077972.1 ENSMUST00000077972.10 ENSMUST00000077972.2 ENSMUST00000077972.3 ENSMUST00000077972.4 ENSMUST00000077972.5 ENSMUST00000077972.6 ENSMUST00000077972.7 ENSMUST00000077972.8 ENSMUST00000077972.9 F8WIZ7 F8WIZ7_MOUSE NM_145525 Osbpl6 uc008kfa.1 uc008kfa.2 uc008kfa.3 uc008kfa.4 Belongs to the OSBP family. cytosol plasma membrane lipid transport nuclear membrane perinuclear endoplasmic reticulum uc008kfa.1 uc008kfa.2 uc008kfa.3 uc008kfa.4 
ENSMUST00000077977.14 Miga2 ENSMUST00000077977.14 mitoguardin 2, transcript variant 6 (from RefSeq NM_001378911.1) A6PX05 ENSMUST00000077977.1 ENSMUST00000077977.10 ENSMUST00000077977.11 ENSMUST00000077977.12 ENSMUST00000077977.13 ENSMUST00000077977.2 ENSMUST00000077977.3 ENSMUST00000077977.4 ENSMUST00000077977.5 ENSMUST00000077977.6 ENSMUST00000077977.7 ENSMUST00000077977.8 ENSMUST00000077977.9 Fam73b MIGA2_MOUSE Miga2 NM_001378911 Q3U4J7 Q3UST7 Q8BK03 uc008jcg.1 uc008jcg.2 uc008jcg.3 uc008jcg.4 Regulator of mitochondrial fusion (PubMed:26711011). Acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD (By similarity). Homodimer and heterodimer; forms heterodimers with MIGA1. Interacts with PLD6/MitoPLD. Interacts (via phosphorylated FFAT motif) with MOSPD2 (By similarity). Mitochondrion outer membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BK03-1; Sequence=Displayed; Name=2; IsoId=Q8BK03-2; Sequence=VSP_030093, VSP_030094; The FFAT motif is involved in the interaction with MOSPD2 and its phosphorylation regulates this interaction. Phosphorylation at Ser-295 of the FFAT motif activates interaction with MOSPD2. Mitochondrial fragmentation: mitochondria become round and show loss of cristae (PubMed:26711011). Female mice show decreased quality of oocytes (PubMed:26716412). Mice lacking both Miga1 and Miga2 show strongly reduced quality of oocytes and are subfertile (PubMed:26716412). Belongs to the mitoguardin family. Sequence=BAE32434.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; mitochondrion mitochondrial outer membrane integral component of plasma membrane mitochondrial fusion membrane integral component of membrane protein homodimerization activity protein heterodimerization activity bone development uc008jcg.1 uc008jcg.2 uc008jcg.3 uc008jcg.4 
ENSMUST00000077983.13 Entr1 ENSMUST00000077983.13 endosome associated trafficking regulator 1, transcript variant 4 (from RefSeq NM_001085408.1) A2AIW0 A2AIW1 ENSMUST00000077983.1 ENSMUST00000077983.10 ENSMUST00000077983.11 ENSMUST00000077983.12 ENSMUST00000077983.2 ENSMUST00000077983.3 ENSMUST00000077983.4 ENSMUST00000077983.5 ENSMUST00000077983.6 ENSMUST00000077983.7 ENSMUST00000077983.8 ENSMUST00000077983.9 ENTR1_MOUSE Entr1 NM_001085408 Q3TQC5 Q6P8W2 Q8BIV5 Q8K0I8 Q9D1V2 Q9D4S1 Q9D5W1 Sdccag3 uc008iva.1 uc008iva.2 uc008iva.3 May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (PubMed:16332174). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (By similarity). Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis. Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27- retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1. Plays a role in the formation of cilia. Involved in cargo protein localization, such as PKD2, at primary cilia (By similarity). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF- induced apoptosis (PubMed:16332174). Found in a complex with ENTR1, PTPN13 and GIT1. Interacts with PTPN13 (via the FERM domain) (By similarity). Interacts (via N- terminus) with GIT1 (via N- and C-terminus); this interaction is direct (PubMed:23108400). Interacts with NOD2. Interacts (via N-terminus) with IFT88. Interacts with VPS35. Cytoplasm Early endosome Endosome Recycling endosome Midbody Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body Note=Colocalizes in a WASHC2- dependent manner with the retromer CSC complex at endosomes. During cytokinesis colocalized with PTPN13 at the midbody. Colocalizes with IFT88 and gamma-tubulin at the basal body of primary cilia. Colocalizes with IFT88 and pericentrin at the centrosome. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=A2AIW0-1; Sequence=Displayed; Name=2; IsoId=A2AIW0-2; Sequence=VSP_032180; Name=3; IsoId=A2AIW0-3; Sequence=VSP_032179; Name=4; IsoId=A2AIW0-4; Sequence=VSP_032178; Name=5; IsoId=A2AIW0-5; Sequence=VSP_032183; Name=6; IsoId=A2AIW0-6; Sequence=VSP_032180, VSP_032181, VSP_032182; Tne N-terminal domain is necessary and sufficient for basal body localization and ciliogenesis. Phosphorylated. Belongs to the ENTR1 family. Sequence=BAB30158.1; Type=Erroneous initiation; Evidence=; Sequence=BAB32357.1; Type=Frameshift; Evidence=; molecular_function cytoplasm endosome early endosome centrosome microtubule organizing center cytoskeleton cell cycle protein transport cell projection organization midbody retromer complex regulation of cytokinesis ciliary basal body cell projection positive regulation of cilium assembly cell division recycling endosome positive regulation of protein localization to cilium retrograde transport, endosome to plasma membrane uc008iva.1 uc008iva.2 uc008iva.3 
ENSMUST00000077985.4 Gpbar1 ENSMUST00000077985.4 G protein-coupled bile acid receptor 1 (from RefSeq NM_174985.2) ENSMUST00000077985.1 ENSMUST00000077985.2 ENSMUST00000077985.3 GPBAR_MOUSE NM_174985 Q80SS6 Tgr5 uc007blq.1 uc007blq.2 uc007blq.3 Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids (By similarity). Involved in bile acid promoted GLP1R secretion. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity cytoplasm plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bile acid receptor activity bile acid signaling pathway regulation of bicellular tight junction assembly uc007blq.1 uc007blq.2 uc007blq.3 
ENSMUST00000077988.8 Tmc2 ENSMUST00000077988.8 transmembrane channel-like gene family 2 (from RefSeq NM_138655.1) ENSMUST00000077988.1 ENSMUST00000077988.2 ENSMUST00000077988.3 ENSMUST00000077988.4 ENSMUST00000077988.5 ENSMUST00000077988.6 ENSMUST00000077988.7 NM_138655 Q7TQB1 Q8R4P4 TMC2_MOUSE uc008mik.1 uc008mik.2 Probable ion channel required for the normal function of cochlear hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity). Interacts with TOMT. The interaction of TMC1 and TMC2 with TOMT is required for the transportation of TMC1/2 into the stereocilia of hair cells (PubMed:28504928). Interacts (via N-terminus) with both isoforms CD1 and CD3 of PCDH15 (PubMed:25114259). Interacts with CIB2 (PubMed:28663585). Cell membrane ; Multi-pass membrane protein Note=Localized to the stereocilia of the cochlear hair cells. Inner ear and testis. Expressed at low, constant levels in temporal bone from embryonic day 14 to day 1 after birth. Increases by 8 to 16-fold at day 5, 10 and 20. Belongs to the TMC family. ion channel activity voltage-gated calcium channel activity protein binding plasma membrane integral component of plasma membrane ion transport mechanically-gated ion channel activity membrane integral component of membrane stereocilium tip detection of mechanical stimulus involved in sensory perception of sound vestibular reflex calcium ion transmembrane transport regulation of calcium ion transmembrane transport uc008mik.1 uc008mik.2 
ENSMUST00000078001.7 Tex101 ENSMUST00000078001.7 testis expressed gene 101 (from RefSeq NM_019981.2) ENSMUST00000078001.1 ENSMUST00000078001.2 ENSMUST00000078001.3 ENSMUST00000078001.4 ENSMUST00000078001.5 ENSMUST00000078001.6 NM_019981 Q9JMI7 TX101_MOUSE Tex101 uc009fqf.1 uc009fqf.2 uc009fqf.3 Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct probably through molecule adhesion ADAM3 (PubMed:23633567, PubMed:23969891). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity). Interacts with VAMP3 (PubMed:16678124). Interacts with LY6K (PubMed:18503752). Interacts with DPEP3; co-localized on the cell surface of spermatocytes, spermatids, and testicular spermatozoa, co- localized only in cytoplasmic droplets of caput and corpus epididymal sperm (PubMed:21724266). Interacts with ADAM3; co-localized on sperm surface (PubMed:23633567, PubMed:23969891). Interacts with ADAM5 (PubMed:23969891). Cell membrane ipid- anchor, GPI-anchor Membrane raft Cytoplasmic vesicle, secretory vesicle, acrosome Secreted toplasmic vesicle Note=Located on plasma membrane of spermatocytes, round and elongated spermatids, and testicular spermatozoa. Detected in testis and ovary (PubMed:11207211, PubMed:15689535, PubMed:15917346, PubMed:16388701, PubMed:23969891). Expressed in spermatocytes, spermatids and testicular spermatozoa, but not in spermatogonia or interstitial cells (PubMed:18620756). Expressed abundantly in testicular germ cells (TGCs) but mostly disappeared from epididymal spermatozoa (PubMed:23633567). Detected in prospermatogonia in embryos after 14 days of development and until 8 days after birth. Not detectable in spermatogonia from over 10 day old animals. Highly expressed in spermatocytes and spermatids from 12-28 day old animals, but not in spermatogonia. Detected in embryonic ovary after 14 days of development and in newly born animals. Expression is much reduced in ovary from 4 day old animals, and not detectable thereafter. Not detectable in oocytes that are surrounded by follicular cells. N-glycosylated; by high mannose and/or biantennary complex and/or certain types of hybrid oligosaccharides; possesses different oligosaccharides chains according to its subcellular localization in the testis. Sheds from membrane raft by ACE and released from the cell surface of epididymal sperm while it passes through the caput epididymis leading to disappearance of TEX101 on spermatozoa; is essential to produce fertile spermatozoa. Knockout Tex101 mice are viable and show no overt developmental abnormalities. Males are infertile. acrosomal vesicle acrosomal membrane positive regulation of leukocyte activation protein binding extracellular region plasma membrane binding of sperm to zona pellucida fertilization membrane flagellated sperm motility anchored component of membrane cytoplasmic vesicle membrane raft anchored component of plasma membrane positive regulation of peptidyl-tyrosine phosphorylation positive regulation of release of sequestered calcium ion into cytosol regulation of flagellated sperm motility uc009fqf.1 uc009fqf.2 uc009fqf.3 
ENSMUST00000078034.5 Rpl9-ps6 ENSMUST00000078034.5 Component of the large ribosomal subunit. (from UniProt A0A140T8T4) A0A140T8T4 A0A140T8T4_MOUSE BC086937 ENSMUST00000078034.1 ENSMUST00000078034.2 ENSMUST00000078034.3 ENSMUST00000078034.4 Rpl9-ps6 uc289rri.1 uc289rri.2 uc289rri.3 Component of the large ribosomal subunit. Cytoplasm Belongs to the universal ribosomal protein uL6 family. cytoplasmic translation structural constituent of ribosome ribosome translation rRNA binding cytosolic large ribosomal subunit uc289rri.1 uc289rri.2 uc289rri.3 
ENSMUST00000078049.12 Nfatc1 ENSMUST00000078049.12 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1, transcript variant 2 (from RefSeq NM_198429.2) ENSMUST00000078049.1 ENSMUST00000078049.10 ENSMUST00000078049.11 ENSMUST00000078049.2 ENSMUST00000078049.3 ENSMUST00000078049.4 ENSMUST00000078049.5 ENSMUST00000078049.6 ENSMUST00000078049.7 ENSMUST00000078049.8 ENSMUST00000078049.9 NM_198429 Nfatc1 Q6P7T9 Q6P7T9_MOUSE uc008fte.1 uc008fte.2 uc008fte.3 uc008fte.4 DNA binding transcription factor activity, sequence-specific DNA binding regulation of transcription, DNA-templated uc008fte.1 uc008fte.2 uc008fte.3 uc008fte.4 
ENSMUST00000078070.10 Ipcef1 ENSMUST00000078070.10 interaction protein for cytohesin exchange factors 1, transcript variant 5 (from RefSeq NM_001347225.1) ENSMUST00000078070.1 ENSMUST00000078070.2 ENSMUST00000078070.3 ENSMUST00000078070.4 ENSMUST00000078070.5 ENSMUST00000078070.6 ENSMUST00000078070.7 ENSMUST00000078070.8 ENSMUST00000078070.9 ICEF1_MOUSE Kiaa0403 NM_001347225 Q3TZY2 Q5DU31 Q8CAP9 uc057khw.1 uc057khw.2 uc057khw.3 Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. Interacts with guanine-nucleotide exchange factors PSCD1, PSCD2, PSCD3 and PSCD4. Cytoplasm Cell membrane Note=Translocated with PSCD2 to the plasma membrane upon epidermal growth factor (EGF) stimulation. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5DU31-1; Sequence=Displayed; Name=2; IsoId=Q5DU31-2; Sequence=VSP_032683; Name=3; IsoId=Q5DU31-3; Sequence=VSP_032684, VSP_032685; Sequence=BAC29953.1; Type=Erroneous initiation; Evidence=; Sequence=BAD90405.1; Type=Erroneous initiation; Evidence=; Sequence=BAE34075.1; Type=Erroneous initiation; Evidence=; cytoplasm cytosol plasma membrane membrane protein domain specific binding uc057khw.1 uc057khw.2 uc057khw.3 
ENSMUST00000078079.11 Eif1a ENSMUST00000078079.11 eukaryotic translation initiation factor 1A, transcript variant 2 (from RefSeq NM_010120.5) ENSMUST00000078079.1 ENSMUST00000078079.10 ENSMUST00000078079.2 ENSMUST00000078079.3 ENSMUST00000078079.4 ENSMUST00000078079.5 ENSMUST00000078079.6 ENSMUST00000078079.7 ENSMUST00000078079.8 ENSMUST00000078079.9 IF1A_MOUSE NM_010120 O88847 Q60872 Q8R2M4 Q9CX76 Q9DB61 uc008evs.1 uc008evs.2 uc008evs.3 uc008evs.4 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Component of the 43S pre-initiation complex (43S PIC), which is composed of the 40S ribosomal subunit, EIF1, eIF1A (EIF1AX), eIF3 complex, EIF5 and eIF2-GTP-initiator tRNA complex (eIF2 ternary complex). Interacts with EIF5; this interaction contributes to the maintenance of EIF1 within the open 43S PIC. Interacts through its C- terminal domain (CTD) with the CTD of EIF5B; from the location of the start codon by the 43S complex until the formation of the 80S complex. Cytoplasm Belongs to the eIF-1A family. RNA binding translation initiation factor activity translation translational initiation ribosomal large subunit binding uc008evs.1 uc008evs.2 uc008evs.3 uc008evs.4 
ENSMUST00000078084.7 Rsrp1 ENSMUST00000078084.7 arginine/serine rich protein 1 (from RefSeq NM_023665.3) D4Wsu53e ENSMUST00000078084.1 ENSMUST00000078084.2 ENSMUST00000078084.3 ENSMUST00000078084.4 ENSMUST00000078084.5 ENSMUST00000078084.6 MNCb-0169 NM_023665 Q3UC65 Q80Y97 Q9CSN6 Q9D194 Q9JJF1 RSRP1_MOUSE uc008vfx.1 uc008vfx.2 uc008vfx.3 Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UC65-1; Sequence=Displayed; Name=2; IsoId=Q3UC65-2; Sequence=VSP_027308; Name=3; IsoId=Q3UC65-3; Sequence=VSP_027309, VSP_027310; Phosphorylated. Phosphorylation at Ser-118 and Ser-120 mediates the interaction with spliceosome proteins. [Isoform 2]: May be due to intron retention. Belongs to the RSRP family. It is uncertain whether Met-1 or Met-6 is the initiator. cellular_component biological_process uc008vfx.1 uc008vfx.2 uc008vfx.3 
ENSMUST00000078090.12 Mllt3 ENSMUST00000078090.12 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3, transcript variant 1 (from RefSeq NM_027326.4) A2AM29 AF9_MOUSE Af9 ENSMUST00000078090.1 ENSMUST00000078090.10 ENSMUST00000078090.11 ENSMUST00000078090.2 ENSMUST00000078090.3 ENSMUST00000078090.4 ENSMUST00000078090.5 ENSMUST00000078090.6 ENSMUST00000078090.7 ENSMUST00000078090.8 ENSMUST00000078090.9 NM_027326 Q8VDR6 Q99MK4 uc008tmp.1 uc008tmp.2 uc008tmp.3 Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3. In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones. Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than conferring, HSC stemness. Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L. Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3) (By similarity). Interacts with BCOR (By similarity). Interacts with CBX8 (PubMed:11439343). Interacts with ALKBH4 (By similarity). Nucleus romosome Note=Colocalizes with acylated histone H3. H3 Colocalizes with histone H3 crotonylated at 'Lys-18' (H3K18cr). Ubiquitously expressed. Strong expression in the spleen. The YEATS domain specifically recognizes and binds acylated histones, with a marked preference for histones that are crotonylated. Also binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity. Binds crotonylated lysine through a non-canonical pi-pi-pi stacking mechanism. The YEATS domain also binds DNA. chromatin binding protein binding nucleus chromosome regulation of transcription, DNA-templated segment specification transcription elongation factor complex anterior/posterior pattern specification histone binding positive regulation of transcription, DNA-templated lysine-acetylated histone binding negative regulation of canonical Wnt signaling pathway positive regulation of Wnt signaling pathway, planar cell polarity pathway uc008tmp.1 uc008tmp.2 uc008tmp.3 
ENSMUST00000078099.4 Proca1 ENSMUST00000078099.4 protein interacting with cyclin A1, transcript variant 2 (from RefSeq NM_001045516.2) B0QZF6 B0QZF6_MOUSE ENSMUST00000078099.1 ENSMUST00000078099.2 ENSMUST00000078099.3 NM_001045516 Proca1 uc007kin.1 uc007kin.2 uc007kin.3 uc007kin.1 uc007kin.2 uc007kin.3 
ENSMUST00000078121.4 Defa35 ENSMUST00000078121.4 defensin, alpha, 35 (from RefSeq NM_001177481.1) Defa35 E9QLQ1 E9QLQ1_MOUSE ENSMUST00000078121.1 ENSMUST00000078121.2 ENSMUST00000078121.3 NM_001177481 uc012gap.1 uc012gap.2 uc012gap.3 Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc012gap.1 uc012gap.2 uc012gap.3 
ENSMUST00000078124.8 Cfl2 ENSMUST00000078124.8 cofilin 2, muscle (from RefSeq NM_007688.2) Cfl2 ENSMUST00000078124.1 ENSMUST00000078124.2 ENSMUST00000078124.3 ENSMUST00000078124.4 ENSMUST00000078124.5 ENSMUST00000078124.6 ENSMUST00000078124.7 NM_007688 Q3UHW9 Q3UHW9_MOUSE uc007nnx.1 uc007nnx.2 uc007nnx.3 Belongs to the actin-binding proteins ADF family. actin binding actin cytoskeleton Z disc actin filament depolymerization positive regulation of actin filament depolymerization I band uc007nnx.1 uc007nnx.2 uc007nnx.3 
ENSMUST00000078139.13 Asph ENSMUST00000078139.13 aspartate-beta-hydroxylase, transcript variant 1 (from RefSeq NM_023066.3) ASPH_MOUSE Bah ENSMUST00000078139.1 ENSMUST00000078139.10 ENSMUST00000078139.11 ENSMUST00000078139.12 ENSMUST00000078139.2 ENSMUST00000078139.3 ENSMUST00000078139.4 ENSMUST00000078139.5 ENSMUST00000078139.6 ENSMUST00000078139.7 ENSMUST00000078139.8 ENSMUST00000078139.9 NM_023066 Q6P8S1 Q8BSY0 Q9EPA6 Q9EQ64 uc008ryf.1 uc008ryf.2 uc008ryf.3 uc008ryf.4 [Isoform 1]: Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. Reaction=2-oxoglutarate + L-aspartyl-[protein] + O2 = 3-hydroxy-L- aspartyl-[protein] + CO2 + succinate; Xref=Rhea:RHEA:11508, Rhea:RHEA-COMP:9867, Rhea:RHEA-COMP:14951, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:17427, ChEBI:CHEBI:29961, ChEBI:CHEBI:30031; EC=1.14.11.16; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Monomer. Isoform 2 interacts with CASQ2. [Isoform 1]: Endoplasmic reticulum membrane ; Single-pass type II membrane protein [Isoform 2]: Sarcoplasmic reticulum membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BSY0-1; Sequence=Displayed; Name=2; Synonyms=Junctin; IsoId=Q8BSY0-2; Sequence=VSP_056792, VSP_056793, VSP_056794; Name=3; IsoId=Q8BSY0-3; Sequence=VSP_060973, VSP_060974, VSP_060975; Isoform 1 is detected in heart, liver and ovary (at protein level). Detected in heart ventricle. Isoform 1 is widely expressed. Isoform 2 is detected in heart and skeletal muscle. Strongly expressed in the snout, limbs and eye of 11.5 dpc and 12 dpc. Strong localization of the protein in the lens of the developing eye at all three stages. Selective disruption of isoform 1 abolishes liver aspartyl beta-hydroxylase activity, but does not affect the expression of isoform 2. Mice lacking isoform 1 have normal blood chemistry, do not present blood coagulation defects and appear more or less normal, except for shorter snouts, mild defects of the palate ridges, syndactily due to fusion of soft tissues and reduced litter size from mutant females, while male fertility appears normal. Mice lacking isoform 2 show no visible phenotype. Belongs to the aspartyl/asparaginyl beta-hydroxylase family. peptide-aspartate beta-dioxygenase activity calcium ion binding protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane pattern specification process negative regulation of cell proliferation positive regulation of calcium ion transport into cytosol membrane integral component of membrane oxidoreductase activity sarcoplasmic reticulum peptidyl-amino acid modification integral component of endoplasmic reticulum membrane regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity regulation of protein stability activation of store-operated calcium channel activity cortical endoplasmic reticulum sarcoplasmic reticulum membrane response to ATP limb morphogenesis peptidyl-aspartic acid hydroxylation positive regulation of proteolysis positive regulation of transcription, DNA-templated metal ion binding dioxygenase activity regulation of cytosolic calcium ion concentration oxidation-reduction process palate development face morphogenesis calcium ion transmembrane transport cellular response to calcium ion positive regulation of intracellular protein transport activation of cysteine-type endopeptidase activity regulation of protein depolymerization uc008ryf.1 uc008ryf.2 uc008ryf.3 uc008ryf.4 
ENSMUST00000078162.4 Or52n4b ENSMUST00000078162.4 olfactory receptor family 52 subfamily N member 4B (from RefSeq NM_001011527.1) ENSMUST00000078162.1 ENSMUST00000078162.2 ENSMUST00000078162.3 NM_001011527 Olfr503 Or52n4b Q7TRU8 Q7TRU8_MOUSE uc009jcn.1 uc009jcn.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jcn.1 uc009jcn.2 
ENSMUST00000078170.7 Dynlrb2 ENSMUST00000078170.7 dynein light chain roadblock-type 2 (from RefSeq NM_029297.1) DLRB2_MOUSE Dncl2b Dnlc2b ENSMUST00000078170.1 ENSMUST00000078170.2 ENSMUST00000078170.3 ENSMUST00000078170.4 ENSMUST00000078170.5 ENSMUST00000078170.6 NM_029297 Q9DAJ5 uc009nog.1 uc009nog.2 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non- catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1 and DYNC1I2. Self-associates. Interacts with DYNLRB1 (By similarity). Cytoplasm, cytoskeleton. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DAJ5-1; Sequence=Displayed; Name=2; IsoId=Q9DAJ5-2; Sequence=VSP_007238; Belongs to the GAMAD family. motor activity protein binding cytoplasm centrosome cytoskeleton cytoplasmic dynein complex microtubule microtubule-based movement dynein complex dynein intermediate chain binding uc009nog.1 uc009nog.2 
ENSMUST00000078182.6 Gng8 ENSMUST00000078182.6 guanine nucleotide binding protein (G protein), gamma 8, transcript variant 1 (from RefSeq NM_010320.4) ENSMUST00000078182.1 ENSMUST00000078182.2 ENSMUST00000078182.3 ENSMUST00000078182.4 ENSMUST00000078182.5 Gng8 NM_010320 Q3UMY0 Q3UMY0_MOUSE uc009fik.1 uc009fik.2 uc009fik.3 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units; alpha, beta and gamma. Cell membrane ipid-anchor ; Cytoplasmic side mbrane ; Lipid-anchor ; Cytoplasmic side Belongs to the G protein gamma family. GTPase activity heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway nervous system development membrane uc009fik.1 uc009fik.2 uc009fik.3 
ENSMUST00000078193.5 Magea1 ENSMUST00000078193.5 MAGE family member A1 (from RefSeq NM_020015.2) ENSMUST00000078193.1 ENSMUST00000078193.2 ENSMUST00000078193.3 ENSMUST00000078193.4 Magea1 NM_020015 O89006 O89006_MOUSE uc009uro.1 uc009uro.2 uc009uro.3 uc009uro.4 molecular_function cellular_component biological_process uc009uro.1 uc009uro.2 uc009uro.3 uc009uro.4 
ENSMUST00000078207.4 Or1o11 ENSMUST00000078207.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt F6Z8L7) BC132008 ENSMUST00000078207.1 ENSMUST00000078207.2 ENSMUST00000078207.3 F6Z8L7 F6Z8L7_MOUSE Olfr108 Or1o11 uc289kzq.1 uc289kzq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kzq.1 uc289kzq.2 
ENSMUST00000078218.11 Serhl ENSMUST00000078218.11 serine hydrolase-like (from RefSeq NM_023475.3) ENSMUST00000078218.1 ENSMUST00000078218.10 ENSMUST00000078218.2 ENSMUST00000078218.3 ENSMUST00000078218.4 ENSMUST00000078218.5 ENSMUST00000078218.6 ENSMUST00000078218.7 ENSMUST00000078218.8 ENSMUST00000078218.9 NM_023475 Q9DCZ8 Q9EPB5 SERHL_MOUSE uc011zwz.1 uc011zwz.2 uc011zwz.3 Probable serine hydrolase. May be related to cell muscle hypertrophy. Cytoplasm, perinuclear region. Peroxisome. Note=Concentrated in perinuclear vesicles. May be located in peroxisomes. Event=Alternative splicing; Named isoforms=2; Name=Serhl-1; IsoId=Q9EPB5-1; Sequence=Displayed; Name=Serhl-2; Synonyms=short; IsoId=Q9EPB5-2; Sequence=Not described; Ubiquitous. High protein expression in skeletal and cardiac muscle. Present in both unfused and recently fused myotubes, but not thereafter. Induced by passive stretch of skeletal muscle. Belongs to the AB hydrolase superfamily. cytoplasm mitochondrion peroxisome hydrolase activity cytoplasmic vesicle perinuclear region of cytoplasm uc011zwz.1 uc011zwz.2 uc011zwz.3 
ENSMUST00000078222.9 Ckmt1 ENSMUST00000078222.9 creatine kinase, mitochondrial 1, ubiquitous, transcript variant 7 (from RefSeq NM_001416956.1) Ckmt1 ENSMUST00000078222.1 ENSMUST00000078222.2 ENSMUST00000078222.3 ENSMUST00000078222.4 ENSMUST00000078222.5 ENSMUST00000078222.6 ENSMUST00000078222.7 ENSMUST00000078222.8 NM_001416956 Q545N7 Q545N7_MOUSE uc008lyt.1 uc008lyt.2 uc008lyt.3 Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Exists as an octamer composed of four MTCK homodimers. Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side Belongs to the ATP:guanido phosphotransferase family. nucleotide binding catalytic activity creatine kinase activity ATP binding kinase activity phosphorylation transferase activity transferase activity, transferring phosphorus-containing groups phosphocreatine biosynthetic process uc008lyt.1 uc008lyt.2 uc008lyt.3 
ENSMUST00000078229.5 Pou3f4 ENSMUST00000078229.5 POU domain, class 3, transcription factor 4 (from RefSeq NM_008901.2) Brn-4 Brn4 ENSMUST00000078229.1 ENSMUST00000078229.2 ENSMUST00000078229.3 ENSMUST00000078229.4 NM_008901 Otf9 P25216 P62515 PO3F4_MOUSE uc009ucv.1 uc009ucv.2 uc009ucv.3 uc009ucv.4 Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain. Interacts with HNRNPU. Nucleus. Brain specific. Belongs to the POU transcription factor family. Class-3 subfamily. RNA polymerase II regulatory region sequence-specific DNA binding DNA binding AT DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter brain development sensory perception of sound forebrain neuron differentiation sequence-specific DNA binding inner ear development cochlea morphogenesis negative regulation of mesenchymal cell apoptotic process uc009ucv.1 uc009ucv.2 uc009ucv.3 uc009ucv.4 
ENSMUST00000078259.8 Nsl1 ENSMUST00000078259.8 NSL1, MIS12 kinetochore complex component (from RefSeq NM_198654.3) E9QME3 E9QME3_MOUSE ENSMUST00000078259.1 ENSMUST00000078259.2 ENSMUST00000078259.3 ENSMUST00000078259.4 ENSMUST00000078259.5 ENSMUST00000078259.6 ENSMUST00000078259.7 NM_198654 Nsl1 uc011wyq.1 uc011wyq.2 uc011wyq.3 mitotic sister chromatid segregation MIS12/MIND type complex kinetochore condensed chromosome kinetochore nucleoplasm nuclear speck uc011wyq.1 uc011wyq.2 uc011wyq.3 
ENSMUST00000078264.2 Or2y8 ENSMUST00000078264.2 olfactory receptor family 2 subfamily Y member 8 (from RefSeq NM_207227.1) ENSMUST00000078264.1 NM_207227 Olfr1373 Or2y8 Q7TQT6 Q7TQT6_MOUSE uc007ivc.1 uc007ivc.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC106787.1, BC106786.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007ivc.1 uc007ivc.2 
ENSMUST00000078267.5 H2bc27 ENSMUST00000078267.5 H2B clustered histone 27 (from RefSeq NM_030082.4) ENSMUST00000078267.1 ENSMUST00000078267.2 ENSMUST00000078267.3 ENSMUST00000078267.4 H2B3A_MOUSE H2bu2 Hist3h2ba NM_030082 Q9D2U9 uc007jcr.1 uc007jcr.2 uc007jcr.3 uc007jcr.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. [provided by RefSeq, Sep 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: CJ166245.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Chromosome Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. The human orthologous protein seems not to exist. Belongs to the histone H2B family. nucleosome DNA binding nucleus nucleoplasm chromosome cytosol nucleosome assembly protein heterodimerization activity uc007jcr.1 uc007jcr.2 uc007jcr.3 uc007jcr.4 
ENSMUST00000078271.4 Pcdhb5 ENSMUST00000078271.4 protocadherin beta 5 (from RefSeq NM_053130.3) ENSMUST00000078271.1 ENSMUST00000078271.2 ENSMUST00000078271.3 NM_053130 Pcdhb5 Q91XZ5 Q91XZ5_MOUSE uc008epq.1 uc008epq.2 uc008epq.3 calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epq.1 uc008epq.2 uc008epq.3 
ENSMUST00000078284.13 Habp2 ENSMUST00000078284.13 hyaluronic acid binding protein 2, transcript variant 1 (from RefSeq NM_001329935.1) E9QM92 E9QM92_MOUSE ENSMUST00000078284.1 ENSMUST00000078284.10 ENSMUST00000078284.11 ENSMUST00000078284.12 ENSMUST00000078284.2 ENSMUST00000078284.3 ENSMUST00000078284.4 ENSMUST00000078284.5 ENSMUST00000078284.6 ENSMUST00000078284.7 ENSMUST00000078284.8 ENSMUST00000078284.9 Habp2 NM_001329935 uc008hyt.1 uc008hyt.2 uc008hyt.3 Secreted Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase activity calcium ion binding extracellular region proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc008hyt.1 uc008hyt.2 uc008hyt.3 
ENSMUST00000078286.6 Rpl7l1 ENSMUST00000078286.6 ribosomal protein L7-like 1 (from RefSeq NM_025433.3) ENSMUST00000078286.1 ENSMUST00000078286.2 ENSMUST00000078286.3 ENSMUST00000078286.4 ENSMUST00000078286.5 NM_025433 Q9D8M4 RL7L_MOUSE uc008cuj.1 uc008cuj.2 Belongs to the universal ribosomal protein uL30 family. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) blastocyst formation structural constituent of ribosome nucleolus ribosome cytosolic large ribosomal subunit uc008cuj.1 uc008cuj.2 
ENSMUST00000078289.3 Or8d2b ENSMUST00000078289.3 olfactory receptor family 8 subfamily D member 2D (from RefSeq NM_146815.1) ENSMUST00000078289.1 ENSMUST00000078289.2 NM_146815 Olfr926 Or8d2b Q9EQ98 Q9EQ98_MOUSE uc009oxi.1 uc009oxi.2 uc009oxi.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oxi.1 uc009oxi.2 uc009oxi.3 
ENSMUST00000078307.7 Lyg2 ENSMUST00000078307.7 lysozyme G-like 2 (from RefSeq NM_001033427.3) B9EJU6 ENSMUST00000078307.1 ENSMUST00000078307.2 ENSMUST00000078307.3 ENSMUST00000078307.4 ENSMUST00000078307.5 ENSMUST00000078307.6 Gm776 LYG2_MOUSE NM_001033427 Q3V1I0 uc007ask.1 uc007ask.2 May act as a potent antibacterial protein that may play a role in the innate immunity. Secreted Belongs to the glycosyl hydrolase 23 family. lysozyme activity extracellular region metabolic process peptidoglycan catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds cell wall macromolecule catabolic process defense response to bacterium defense response to Gram-positive bacterium uc007ask.1 uc007ask.2 
ENSMUST00000078308.13 Rasal2 ENSMUST00000078308.13 RAS protein activator like 2, transcript variant 1 (from RefSeq NM_177644.6) E9PW37 E9PW37_MOUSE ENSMUST00000078308.1 ENSMUST00000078308.10 ENSMUST00000078308.11 ENSMUST00000078308.12 ENSMUST00000078308.2 ENSMUST00000078308.3 ENSMUST00000078308.4 ENSMUST00000078308.5 ENSMUST00000078308.6 ENSMUST00000078308.7 ENSMUST00000078308.8 ENSMUST00000078308.9 NM_177644 Rasal2 uc007ddg.1 uc007ddg.2 uc007ddg.3 uc007ddg.4 GTPase activator activity signal transduction regulation of GTPase activity positive regulation of GTPase activity uc007ddg.1 uc007ddg.2 uc007ddg.3 uc007ddg.4 
ENSMUST00000078314.14 Slc22a16 ENSMUST00000078314.14 solute carrier family 22 (organic cation transporter), member 16 (from RefSeq NM_027572.1) ENSMUST00000078314.1 ENSMUST00000078314.10 ENSMUST00000078314.11 ENSMUST00000078314.12 ENSMUST00000078314.13 ENSMUST00000078314.2 ENSMUST00000078314.3 ENSMUST00000078314.4 ENSMUST00000078314.5 ENSMUST00000078314.6 ENSMUST00000078314.7 ENSMUST00000078314.8 ENSMUST00000078314.9 NM_027572 Q3LVC1 Q497L8 S22AG_MOUSE Slc22a16 uc007ewz.1 uc007ewz.2 uc007ewz.3 Facilitative organic cation transporter that mediates the transport of carnitine as well as the polyamine spermidine. Mediates the partially Na(+)-dependent bidirectional transport of carnitine. May mediate L-carnitine secretion from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Reaction=(R)-carnitine(in) = (R)-carnitine(out); Xref=Rhea:RHEA:34959, ChEBI:CHEBI:16347; Evidence=; Reaction=spermidine(in) = spermidine(out); Xref=Rhea:RHEA:35039, ChEBI:CHEBI:57834; Evidence=; Cell membrane ; Multi-pass membrane protein Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q497L8-1; Sequence=Displayed; Name=2; IsoId=Q497L8-2; Sequence=VSP_031339; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. amine transmembrane transporter activity plasma membrane ion transport multicellular organism development spermatogenesis single fertilization organic cation transmembrane transporter activity carnitine transmembrane transporter activity organic cation transport amine transport carnitine transport membrane integral component of membrane transmembrane transporter activity cell differentiation flagellated sperm motility acid secretion transmembrane transport carnitine transmembrane transport uc007ewz.1 uc007ewz.2 uc007ewz.3 
ENSMUST00000078332.13 Mff ENSMUST00000078332.13 mitochondrial fission factor, transcript variant 1 (from RefSeq NM_029409.3) ENSMUST00000078332.1 ENSMUST00000078332.10 ENSMUST00000078332.11 ENSMUST00000078332.12 ENSMUST00000078332.2 ENSMUST00000078332.3 ENSMUST00000078332.4 ENSMUST00000078332.5 ENSMUST00000078332.6 ENSMUST00000078332.7 ENSMUST00000078332.8 ENSMUST00000078332.9 MFF_MOUSE NM_029409 Q3UT87 Q6PCP5 Q91VG0 Q9D3P5 uc007brx.1 uc007brx.2 uc007brx.3 uc007brx.4 Plays a role in mitochondrial and peroxisomal fission (PubMed:23283981, PubMed:30059978). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23283981). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). Homodimer (PubMed:30059978). Interacts with DNM1L (PubMed:30059978). Interacts with C11orf65/MFI; the interaction inhibits MFF interaction with DNM1L (PubMed:30059978). Q6PCP5; Q8K1M6: Dnm1l; NbExp=2; IntAct=EBI-21985996, EBI-2365792; Mitochondrion outer membrane ; Single-pass type IV membrane protein Peroxisome Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6PCP5-1; Sequence=Displayed; Name=2; IsoId=Q6PCP5-2; Sequence=VSP_025959, VSP_025961; Name=3; IsoId=Q6PCP5-3; Sequence=VSP_025961; Name=4; IsoId=Q6PCP5-4; Sequence=VSP_025960; Belongs to the Tango11 family. mitochondrial fission release of cytochrome c from mitochondria protein binding mitochondrion mitochondrial outer membrane peroxisome protein targeting to mitochondrion synaptic vesicle mitochondrial fusion positive regulation of cardiac muscle cell apoptotic process regulation of mitochondrion organization membrane integral component of membrane peroxisome fission cell junction cytoplasmic vesicle integral component of mitochondrial membrane protein homodimerization activity mitochondrial fragmentation involved in apoptotic process macromolecular complex binding synapse GTPase binding protein homooligomerization mitochondrion morphogenesis positive regulation of mitochondrial fission positive regulation of release of cytochrome c from mitochondria positive regulation of protein targeting to membrane regulation of peroxisome organization positive regulation of synaptic vesicle endocytosis synaptic vesicle membrane mitochondrial membrane uc007brx.1 uc007brx.2 uc007brx.3 uc007brx.4 
ENSMUST00000078350.13 Csgalnact1 ENSMUST00000078350.13 chondroitin sulfate N-acetylgalactosaminyltransferase 1, transcript variant 2 (from RefSeq NM_172753.5) CGAT1_MOUSE Chgn Csgalnact1 ENSMUST00000078350.1 ENSMUST00000078350.10 ENSMUST00000078350.11 ENSMUST00000078350.12 ENSMUST00000078350.2 ENSMUST00000078350.3 ENSMUST00000078350.4 ENSMUST00000078350.5 ENSMUST00000078350.6 ENSMUST00000078350.7 ENSMUST00000078350.8 ENSMUST00000078350.9 Galnact1 NM_172753 Q3UNQ5 Q3UZX6 Q5FWX8 Q8BJQ9 Q8BWV9 Q8BZU7 Q8C195 Q8R0M6 uc009lwf.1 uc009lwf.2 uc009lwf.3 uc009lwf.4 Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation, and subsequent endochondral ossification (PubMed:17145758, PubMed:21148564). Moreover, is involved in the metabolism of aggrecan (PubMed:21148564). Reaction=3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)- beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta- D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23464, Rhea:RHEA-COMP:12573, Rhea:RHEA-COMP:12575, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:132093, ChEBI:CHEBI:132105; EC=2.4.1.174; Evidence=; Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein High expression in developing cartilage and during chondrocyte differentiation. Deficient mice are viable and fertile, but decreased body weight and length and abnormal cartilage (PubMed:21148564). Belongs to the chondroitin N- acetylgalactosaminyltransferase family. Sequence=BAE25692.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; endochondral ossification Golgi apparatus acetylgalactosaminyltransferase activity peptidoglycan glycosyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity UDP-N-acetylgalactosamine metabolic process extracellular matrix organization chondroitin sulfate metabolic process chondroitin sulfate biosynthetic process Golgi cisterna membrane UDP-glucuronate metabolic process metal ion binding glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process cartilage development uc009lwf.1 uc009lwf.2 uc009lwf.3 uc009lwf.4 
ENSMUST00000078357.5 Emp2 ENSMUST00000078357.5 epithelial membrane protein 2 (from RefSeq NM_007929.2) ENSMUST00000078357.1 ENSMUST00000078357.2 ENSMUST00000078357.3 ENSMUST00000078357.4 Emp2 NM_007929 Q548I4 Q548I4_MOUSE uc007ydj.1 uc007ydj.2 Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Apical cell membrane Cell membrane Cytoplasm, perinuclear region Golgi apparatus membrane ; Multi-pass membrane protein Membrane raft Membrane ; Multi- pass membrane protein cleus Belongs to the PMP-22/EMP/MP20 family. Lacks conserved residue(s) required for the propagation of feature annotation. positive regulation of cell-matrix adhesion regulation of glomerular filtration integrin binding nucleus cytoplasm plasma membrane actin filament organization cell adhesion cell-matrix adhesion embryo implantation cell death positive regulation of cell proliferation regulation of endothelial cell migration membrane integral component of membrane cell migration kinase binding protein kinase binding bleb assembly activation of protein kinase activity protein localization to cell surface blood vessel endothelial cell migration regulation of kinase activity membrane raft regulation of angiogenesis actin-mediated cell contraction positive regulation of integrin-mediated signaling pathway regulation of vasculogenesis uc007ydj.1 uc007ydj.2 
ENSMUST00000078362.13 Vrk2 ENSMUST00000078362.13 vaccinia related kinase 2, transcript variant 1 (from RefSeq NM_027260.3) ENSMUST00000078362.1 ENSMUST00000078362.10 ENSMUST00000078362.11 ENSMUST00000078362.12 ENSMUST00000078362.2 ENSMUST00000078362.3 ENSMUST00000078362.4 ENSMUST00000078362.5 ENSMUST00000078362.6 ENSMUST00000078362.7 ENSMUST00000078362.8 ENSMUST00000078362.9 NM_027260 Q3U415 Q5F1Z5 Q5SP88 Q8BN21 Q8BPU8 Q8CJ46 Q91WS1 Q9CZF9 VRK2_MOUSE uc007igf.1 uc007igf.2 uc007igf.3 uc007igf.4 uc007igf.5 Serine/threonine kinase that regulates several signal transduction pathways (PubMed:14645249). Modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen- activated protein kinase (MAPK) complexes (By similarity). Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription (By similarity). Phosphorylates histone H3 (By similarity). Phosphorylates 'Thr-18' of p53/TP53, and thereby increases its stability and activity (By similarity). Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain- containing proteins (By similarity). Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1 (By similarity). Blocks the phosphorylation of ERK in response to ERBB2 and HRAS (By similarity). May also phosphorylate MAPK8IP1 (By similarity). Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Interacts with MAP3K7, MAP2K7, MAP2K1, KSR1, RAN and MAPK8IP1. Cytoplasm Endoplasmic reticulum membrane ; Single- pass type IV membrane protein Mitochondrion membrane ; Single-pass type IV membrane protein Nucleus envelope Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BN21-1; Sequence=Displayed; Name=2; IsoId=Q8BN21-2; Sequence=VSP_008543; Name=3; IsoId=Q8BN21-3; Sequence=VSP_008541, VSP_008542; Expressed in liver, kidney and muscle. Weakly expressed in thymus, bone marrow and spleen. Weakly expressed in embryo compared to VRK1 and VRK3. Expressed from 10.5 dpc to 14 dpc in developing liver and then decreases. It increases again from 17.5 dpc and remains thereafter. Highly expressed in hematopoietic embryonic tissues from 10.5 dpc to 14.5 dpc. Weakly expressed in the yolk-sac. Autophosphorylated. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nuclear envelope cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane protein phosphorylation membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation protein kinase binding protein domain specific binding mitochondrial membrane macromolecular complex cellular response to oxidative stress regulation of MAPK cascade protein autophosphorylation regulation of interleukin-1-mediated signaling pathway uc007igf.1 uc007igf.2 uc007igf.3 uc007igf.4 uc007igf.5 
ENSMUST00000078364.4 Ifnl3 ENSMUST00000078364.4 interferon lambda 3 (from RefSeq NM_177396.1) ENSMUST00000078364.1 ENSMUST00000078364.2 ENSMUST00000078364.3 IFNL3_MOUSE Il28 Il28b NM_177396 Q4VK73 Q8CGK6 uc009fze.1 uc009fze.2 Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)- induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. Secreted Belongs to the lambda interferon family. receptor binding cytokine activity extracellular region extracellular space JAK-STAT cascade negative regulation of viral genome replication innate immune response positive regulation of immune response defense response to virus uc009fze.1 uc009fze.2 
ENSMUST00000078367.12 Dzip1l ENSMUST00000078367.12 DAZ interacting protein 1-like, transcript variant 1 (from RefSeq NM_028258.4) DZI1L_MOUSE Dzip1l ENSMUST00000078367.1 ENSMUST00000078367.10 ENSMUST00000078367.11 ENSMUST00000078367.2 ENSMUST00000078367.3 ENSMUST00000078367.4 ENSMUST00000078367.5 ENSMUST00000078367.6 ENSMUST00000078367.7 ENSMUST00000078367.8 ENSMUST00000078367.9 NM_028258 Q499E4 Q8BZI8 Q8C182 Q9CSR1 uc009rem.1 uc009rem.2 uc009rem.3 uc009rem.4 wpy Involved in primary cilium formation (PubMed:28530676). Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane (By similarity). Interacts with SEPTIN2. Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localizes to centrioles and to the distal ends of basal bodies. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q499E4-1; Sequence=Displayed; Name=2; IsoId=Q499E4-2; Sequence=VSP_033160; Belongs to the DZIP C2H2-type zinc-finger protein family. nucleic acid binding cytoplasm centriole cytoskeleton cilium regulation of protein localization ciliary basal body cell projection metal ion binding cilium assembly uc009rem.1 uc009rem.2 uc009rem.3 uc009rem.4 
ENSMUST00000078369.3 H2ac4 ENSMUST00000078369.3 H2A clustered histone 4 (from RefSeq NM_175660.4) C0HKE9 ENSMUST00000078369.1 ENSMUST00000078369.2 H2A1P_MOUSE Hist1h2ap NM_175660 P10812 P22752 Q149U0 Q5SZZ2 uc007put.1 uc007put.2 uc007put.3 uc007put.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007put.1 uc007put.2 uc007put.3 uc007put.4 
ENSMUST00000078371.6 V1ra8 ENSMUST00000078371.6 vomeronasal 1 receptor, A8 (from RefSeq NM_053223.1) B9EHS8 ENSMUST00000078371.1 ENSMUST00000078371.2 ENSMUST00000078371.3 ENSMUST00000078371.4 ENSMUST00000078371.5 NM_053223 Q9EQ48 V1ra8 VN1A8_MOUSE uc009cwx.1 uc009cwx.2 uc009cwx.3 uc009cwx.4 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Cell membrane ; Multi-pass membrane protein Expressed in a subset of sensory neurons located in the apical layer of the vomeronasal organ. Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc009cwx.1 uc009cwx.2 uc009cwx.3 uc009cwx.4 
ENSMUST00000078386.4 Slitrk6 ENSMUST00000078386.4 SLIT and NTRK-like family, member 6 (from RefSeq NM_175499.4) ENSMUST00000078386.1 ENSMUST00000078386.2 ENSMUST00000078386.3 NM_175499 Q8BLL0 Q8C110 SLIK6_MOUSE Sltk6 uc007uyd.1 uc007uyd.2 uc007uyd.3 uc007uyd.4 Regulator of neurite outgrowth required for normal hearing and vision. Cell membrane ; Single-pass type I membrane protein In the embryo, expressed in otic cyst, lateral trunk epidermis and underlying mesodermal tissue, limb bud, maxillary process, cochlea, retina, tongue, tooth primordium, central nervous system, and primordia of visceral organs including lung, gastrointestinal tract and pancreas. In the central nervous system, expressed primarily in dorsal thalamus, cerebellum and medulla. During inner ear development, detected early in the otic vesicle, and later in cochlear and vestibular sensory epithelia. Present in the presumptive organ of Corti by 14.5 dpc, and then confined to the supporting cell types at later stages of embryonic development and at the newborn. In the vestibular sensory epithelia, present at the lumenal surface. However, it is detected in the non-hair cell region, presumably in the lumenal processes of the supporting cells. Transiently expressed in the spiral and vestibular ganglion neurons (at protein level) (PubMed:19936227). First expressed at 8.5 dpc. In the newborn, broadly detected in neural retina. Later, in P10 retina, expression is enhanced in the inner nuclear and outer plexiform layers. Expression in retina decreases as development proceeded, and is detected in the inner nuclear layer and in a subset of cells in the ganglion cell layer of adults (PubMed:23543054). Male and female mice grow without showing any external abnormalities and are fertile but display auditory deficits. In the developing inner ear, mice show pronounced reduction of cochlear innervation, despite normal gross morphology and general organization of the organ of Corti (PubMed:19936227). Adult mice have reduced startle response and impaired auditory brainstem responses consistent with mid-frequency range hearing loss (PubMed:21298075). Retinas in postnatal development display a delay in synaptogenesis (PubMed:23543054). Belongs to the SLITRK family. startle response lens development in camera-type eye auditory receptor cell morphogenesis molecular_function plasma membrane integral component of plasma membrane axonogenesis synapse assembly visual perception sensory perception of sound adult locomotory behavior cell surface membrane integral component of membrane vestibulocochlear nerve development auditory behavior multicellular organism growth inner ear morphogenesis camera-type eye development neuron projection morphogenesis response to stimulus positive regulation of synapse assembly vestibular reflex linear vestibuloocular reflex innervation cell periphery cochlea development uc007uyd.1 uc007uyd.2 uc007uyd.3 uc007uyd.4 
ENSMUST00000078409.5 Trim61 ENSMUST00000078409.5 tripartite motif-containing 61, transcript variant 1 (from RefSeq NM_153110.4) ENSMUST00000078409.1 ENSMUST00000078409.2 ENSMUST00000078409.3 ENSMUST00000078409.4 NM_153110 Q8JZK6 Q8JZK6_MOUSE Rnf35 Trim61 uc009lvg.1 uc009lvg.2 uc009lvg.3 uc009lvg.4 metal ion binding uc009lvg.1 uc009lvg.2 uc009lvg.3 uc009lvg.4 
ENSMUST00000078414.8 Or7a39 ENSMUST00000078414.8 olfactory receptor family 7 subfamily A member 39 (from RefSeq NM_207571.2) ENSMUST00000078414.1 ENSMUST00000078414.2 ENSMUST00000078414.3 ENSMUST00000078414.4 ENSMUST00000078414.5 ENSMUST00000078414.6 ENSMUST00000078414.7 NM_207571 Olfr1355 Or7a39 Q7TQU9 Q7TQU9_MOUSE uc007fyi.1 uc007fyi.2 uc007fyi.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB174231.1, CB173142.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007fyi.1 uc007fyi.2 uc007fyi.3 
ENSMUST00000078422.4 Krtap21-1 ENSMUST00000078422.4 keratin associated protein 21-1 (from RefSeq NM_028621.3) B9EK12 B9EK12_MOUSE ENSMUST00000078422.1 ENSMUST00000078422.2 ENSMUST00000078422.3 Krtap16-7 Krtap21-1 NM_028621 uc007zvp.1 uc007zvp.2 uc007zvp.3 intermediate filament uc007zvp.1 uc007zvp.2 uc007zvp.3 
ENSMUST00000078438.5 Trim31 ENSMUST00000078438.5 tripartite motif-containing 31 (from RefSeq NM_146077.2) ENSMUST00000078438.1 ENSMUST00000078438.2 ENSMUST00000078438.3 ENSMUST00000078438.4 NM_146077 Q8R0K2 TRI31_MOUSE Trim31 uc008cll.1 uc008cll.2 uc008cll.3 E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates (PubMed:27929086, PubMed:27992402). Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria (PubMed:27992402). Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation (PubMed:27929086). Regulator of Src-induced anchorage independent cell growth (PubMed:19665990). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. May form oligomers (By similarity). Interacts with isoform p52shc of SHC1 (PubMed:19665990). Cytoplasm Mitochondrion Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria. Highly expressed in the gastrointestrinal tract, with high expression in the small intestine, moderate in the large intestine and weak in the stomach and esophagus. Up-regulated in response to lipopolysaccharid and IL1B treatment. Auto-ubiquitinated (in vitro). Mice are viable, normal in size and without gross physiological or behavioral abnormalities (PubMed:27992402). Mice are however more susceptible to infection with RNA virus due to impaired cellular antiviral response (PubMed:27992402). Mice also show increased inflammatory response, characterized by enhanced NLRP3 inflammasome activation (PubMed:27929086). Increased NLRP3 inflammasome activation leads to an aggravation of alum-induced peritonitis (PubMed:27929086). In contrast, it attenuates the severity of dextran sodium sulfate- induced colitis, an inflammatory bowel diseases model in which NLRP3 possesses protective roles (PubMed:27929086). Belongs to the TRIM/RBCC family. cytoplasm mitochondrion zinc ion binding protein ubiquitination nuclear body transferase activity negative regulation of viral transcription innate immune response negative regulation of viral entry into host cell metal ion binding positive regulation of sequence-specific DNA binding transcription factor activity regulation of viral release from host cell uc008cll.1 uc008cll.2 uc008cll.3 
ENSMUST00000078442.4 Krtap9-22 ENSMUST00000078442.4 predicted gene 11567 (from RefSeq NM_001101613.1) ENSMUST00000078442.1 ENSMUST00000078442.2 ENSMUST00000078442.3 Gm11567 NM_001101613 OTTMUSG00000002206 Q9D141 Q9D141_MOUSE uc011yev.1 uc011yev.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc011yev.1 uc011yev.2 
ENSMUST00000078451.7 Pirb ENSMUST00000078451.7 paired Ig-like receptor B, transcript variant 1 (from RefSeq NM_011095.2) ENSMUST00000078451.1 ENSMUST00000078451.2 ENSMUST00000078451.3 ENSMUST00000078451.4 ENSMUST00000078451.5 ENSMUST00000078451.6 LIRB3_MOUSE Lilrb3 NM_011095 P97484 uc009ewb.1 uc009ewb.2 uc009ewb.3 uc009ewb.4 May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine- based inhibitor motifs (ITIM). Interacts with LYN, PTPN6/SHP-1 and PTPN11/SHP-2. P97484; P35235: Ptpn11; NbExp=2; IntAct=EBI-15728641, EBI-397236; P97484; PRO_0000000092 [P05067]: APP; Xeno; NbExp=8; IntAct=EBI-15728641, EBI-821758; Cell membrane ingle-pass type I membrane protein Detected in macrophages, splenocytes and B lymphocytes (at protein level). Detected in macrophages, mast cells, splenocytes, peritoneal cells and natural killer cells. Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the downstream protein kinases SYK and BTK. Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-794 and Tyr-824 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2. Belongs to the leukocyte receptor cluster (LRC) present on chromosome 7. beta-amyloid binding B cell homeostasis adaptive immune response immune system process protein binding plasma membrane learning or memory membrane integral component of membrane cytokine-mediated signaling pathway B cell mediated immunity positive regulation of protein dephosphorylation protein homodimerization activity myeloid dendritic cell differentiation macromolecular complex binding negative regulation of protein metabolic process regulation of long-term synaptic potentiation positive regulation of long term synaptic depression uc009ewb.1 uc009ewb.2 uc009ewb.3 uc009ewb.4 
ENSMUST00000078469.3 Mageb5b ENSMUST00000078469.3 MAGE family member B5B (from RefSeq NM_001205268.1) A2A9Q9 A2A9Q9_MOUSE ENSMUST00000078469.1 ENSMUST00000078469.2 Gm14781 Mageb5b NM_001205268 uc029xll.1 uc029xll.2 molecular_function cellular_component biological_process uc029xll.1 uc029xll.2 
ENSMUST00000078471.7 BC048507 ENSMUST00000078471.7 cDNA sequence BC048507 (from RefSeq NM_001001185.3) BC048507 ENSMUST00000078471.1 ENSMUST00000078471.2 ENSMUST00000078471.3 ENSMUST00000078471.4 ENSMUST00000078471.5 ENSMUST00000078471.6 NM_001001185 Q80ZS7 Q80ZS7_MOUSE uc007rbt.1 uc007rbt.2 uc007rbt.3 uc007rbt.4 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Mitochondrion Nucleus Belongs to the dynein light chain family. motor activity cytoplasm cytoskeleton microtubule microtubule associated complex microtubule-based process dynein complex dynein intermediate chain binding dynein light intermediate chain binding positive regulation of ATP-dependent microtubule motor activity, plus-end-directed ATP-dependent microtubule motor activity, plus-end-directed uc007rbt.1 uc007rbt.2 uc007rbt.3 uc007rbt.4 
ENSMUST00000078475.5 Vmn1r64 ENSMUST00000078475.5 vomeronasal 1 receptor 64 (from RefSeq NM_207544.1) ENSMUST00000078475.1 ENSMUST00000078475.2 ENSMUST00000078475.3 ENSMUST00000078475.4 NM_207544 Q8R2B8 Q8R2B8_MOUSE V1rd11 Vmn1r64 uc009fal.1 uc009fal.2 uc009fal.3 uc009fal.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009fal.1 uc009fal.2 uc009fal.3 uc009fal.4 
ENSMUST00000078482.13 Dchs1 ENSMUST00000078482.13 dachsous cadherin related 1 (from RefSeq NM_001162943.1) E9PVD3 ENSMUST00000078482.1 ENSMUST00000078482.10 ENSMUST00000078482.11 ENSMUST00000078482.12 ENSMUST00000078482.2 ENSMUST00000078482.3 ENSMUST00000078482.4 ENSMUST00000078482.5 ENSMUST00000078482.6 ENSMUST00000078482.7 ENSMUST00000078482.8 ENSMUST00000078482.9 NM_001162943 PCD16_MOUSE uc009izh.1 uc009izh.2 uc009izh.3 uc009izh.4 Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). Heterophilic interaction with FAT4; this interaction affects their respective protein levels. Cell membrane ; Single-pass type I membrane protein Note=In the embryonic cortex, FAT4 and DCHS1 accumulated at the cell-cell boundaries located apical to the adherens junction. Expressed in the epicardium and atrioventricular sulcus (at protein level). Expressed in all layers of the developing brain, with expression being most prominent at the ventricular margin. Expressed throughout cardiac development in the endothelial cells and interstitial cells of the developing valves (at protein level). Expression is observed in the endocardium and mesenchyme of the superior and inferior cushions at day 11.5 dpc. At days 13.5 dpc and 15.5 dpc, expression is observed in the forming anterior and posterior mitral leaflets (PubMed:26258302). Deficient mice exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities. DCHS1 and FAT4 single mutants and DCHS1/FAT4 double mutants have similar phenotypes. Heterozygous mice lacking one DCHS1 allele exhibit mitral valve prolapse with posterior leaflet elongation, leaflet thickening, and myxomatous degeneration with increased proteoglycan accumulation in both mitral leaflets (PubMed:26258302). branching involved in ureteric bud morphogenesis establishment of planar polarity kidney development heart morphogenesis mitral valve morphogenesis mitral valve formation cell migration involved in endocardial cushion formation molecular_function calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules pattern specification process anatomical structure morphogenesis membrane integral component of membrane cell migration neural tube development neurogenesis hippo signaling post-anal tail morphogenesis ossification involved in bone maturation apical part of cell digestive tract development nephron development condensed mesenchymal cell proliferation protein localization to plasma membrane cochlea development cell-cell adhesion uc009izh.1 uc009izh.2 uc009izh.3 uc009izh.4 
ENSMUST00000078494.6 Rag1 ENSMUST00000078494.6 recombination activating 1 (from RefSeq NM_009019.2) A2AVN8 ENSMUST00000078494.1 ENSMUST00000078494.2 ENSMUST00000078494.3 ENSMUST00000078494.4 ENSMUST00000078494.5 NM_009019 P15919 RAG1_MOUSE uc008lhk.1 uc008lhk.2 uc008lhk.3 uc008lhk.4 Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM- dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. Mediates polyubiquitination of KPNA1. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+). ; Homodimer. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Interacts with DCAF1, leading to recruitment of the CUL4A-RBX1-DDB1- DCAF1/VPRBP complex to ubiquitinate proteins and limit error-prone repair during V(D)J recombination. P15919; P15919: Rag1; NbExp=4; IntAct=EBI-7602168, EBI-7602168; P15919; P21784: Rag2; NbExp=4; IntAct=EBI-7602168, EBI-7602123; Nucleus Maturing lymphoid cells and central nervous system. The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity. The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. Autoubiquitinated in the presence of CDC34/UBCH3. Mice display a severe combined immunodeficiency phenotype. The have a small lymphoid organs that do not contain mature B and T-lymphocytes. The arrest of B- and T-cell differentiation occurs at an early stage and correlates with the inability to perform V(D)J recombination. The frequency of homologous immunoglobulin pairing is much lower. No obvious neuroanatomical or behavioral abnormalities have been observed. Belongs to the RAG1 family. adaptive immune response pre-B cell allelic exclusion DNA binding catalytic activity nuclease activity endonuclease activity ubiquitin-protein transferase activity protein binding nucleus nucleoplasm DNA recombination chromatin organization metabolic process zinc ion binding visual learning histone monoubiquitination transferase activity hydrolase activity B cell differentiation T cell differentiation in thymus V(D)J recombination histone binding identical protein binding protein homodimerization activity T cell homeostasis negative regulation of cysteine-type endopeptidase activity involved in apoptotic process sequence-specific DNA binding regulation of T cell differentiation positive regulation of T cell differentiation metal ion binding thymus development protein autoubiquitination ubiquitin protein ligase activity negative regulation of T cell apoptotic process negative regulation of thymocyte apoptotic process nucleic acid phosphodiester bond hydrolysis DNA recombinase complex endodeoxyribonuclease complex regulation of behavioral fear response double-stranded DNA endodeoxyribonuclease activity uc008lhk.1 uc008lhk.2 uc008lhk.3 uc008lhk.4 
ENSMUST00000078508.7 Sp7 ENSMUST00000078508.7 Sp7 transcription factor 7, transcript variant 1 (from RefSeq NM_130458.4) ENSMUST00000078508.1 ENSMUST00000078508.2 ENSMUST00000078508.3 ENSMUST00000078508.4 ENSMUST00000078508.5 ENSMUST00000078508.6 NM_130458 Osx Q8C5R3 Q8C6A7 Q8VI67 SP7_MOUSE uc007xvm.1 uc007xvm.2 uc007xvm.3 Transcriptional activator essential for osteoblast differentiation (PubMed:11792318, PubMed:17510056, PubMed:30026585). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (PubMed:11792318, PubMed:17510056). Interacts with RIOX1; the interaction is direct and inhibits transcription activator activity. Q8VI67; Q9JJF3: Riox1; NbExp=3; IntAct=EBI-7608836, EBI-7608809; Q8VI67; Q9H6W3: RIOX1; Xeno; NbExp=6; IntAct=EBI-7608836, EBI-2513645; Nucleus Osteoblast/chondrocyte specific. In response to ascorbic acid induction, expression is activated by NFE2L1 in osteoblasts. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Propionylated (PubMed:30026585). Depropionylation at Lys-368 by SIRT7 activates transcription factor activity and positively regulates bone formation by osteoblasts (PubMed:30026585). Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours (By similarity). Death in the immediate postnatal period due to difficulty in breathing. Mice rapidly become cyanotic and die within 15 min of birth. New-born homozygous show severe inward bending of forelimbs and hindlimbs. They develop a normal cartilage skeleton but fail to form bone and to express osteoblast-specific marker genes. In endochondral skeletal elements, mesenchymal cells together with osteoclasts and blood vessels, invade the mineralized cartilage matrix. Belongs to the Sp1 C2H2-type zinc-finger protein family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding osteoblast differentiation nucleic acid binding DNA binding protein binding nucleus nucleoplasm cytoplasm regulation of transcription from RNA polymerase II promoter DEAD/H-box RNA helicase binding positive regulation of transcription from RNA polymerase II promoter metal ion binding hematopoietic stem cell differentiation positive regulation of stem cell differentiation uc007xvm.1 uc007xvm.2 uc007xvm.3 
ENSMUST00000078521.7 Dyrk4 ENSMUST00000078521.7 dual-specificity tyrosine phosphorylation regulated kinase 4 (from RefSeq NM_207210.3) DYRK4_MOUSE Dyrk4 ENSMUST00000078521.1 ENSMUST00000078521.2 ENSMUST00000078521.3 ENSMUST00000078521.4 ENSMUST00000078521.5 ENSMUST00000078521.6 NM_207210 Q80WP9 Q8BI55 uc009dvh.1 uc009dvh.2 uc009dvh.3 Possible non-essential role in spermiogenesis. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8BI55-1; Sequence=Displayed; Name=2 ; IsoId=Q8BI55-2; Sequence=VSP_052456, VSP_052457; Highly expressed in testes. Autophosphorylation on Tyr-379 in the activation loop is required for kinase activity. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity ATP binding nucleus cytoplasm cytoskeleton protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular membrane-bounded organelle metal ion binding uc009dvh.1 uc009dvh.2 uc009dvh.3 
ENSMUST00000078525.7 Rnf150 ENSMUST00000078525.7 ring finger protein 150 (from RefSeq NM_177378.4) ENSMUST00000078525.1 ENSMUST00000078525.2 ENSMUST00000078525.3 ENSMUST00000078525.4 ENSMUST00000078525.5 ENSMUST00000078525.6 Kiaa1214 NM_177378 Q5DTZ6 RN150_MOUSE uc009mjt.1 uc009mjt.2 uc009mjt.3 uc009mjt.4 Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5DTZ6-1; Sequence=Displayed; Name=2; IsoId=Q5DTZ6-2; Sequence=VSP_023848; Name=3; IsoId=Q5DTZ6-3; Sequence=VSP_023849, VSP_023850; Sequence=BAD90433.1; Type=Erroneous initiation; Evidence=; cellular_component ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination metal ion binding ubiquitin protein ligase activity uc009mjt.1 uc009mjt.2 uc009mjt.3 uc009mjt.4 
ENSMUST00000078527.13 Rxfp1 ENSMUST00000078527.13 relaxin/insulin-like family peptide receptor 1 (from RefSeq NM_212452.3) ENSMUST00000078527.1 ENSMUST00000078527.10 ENSMUST00000078527.11 ENSMUST00000078527.12 ENSMUST00000078527.2 ENSMUST00000078527.3 ENSMUST00000078527.4 ENSMUST00000078527.5 ENSMUST00000078527.6 ENSMUST00000078527.7 ENSMUST00000078527.8 ENSMUST00000078527.9 Gm1018 Lgr7 NM_212452 Q6R6I7 Q80UD3 RXFP1_MOUSE uc008pnv.1 uc008pnv.2 uc008pnv.3 Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. Interacts with C1QTNF8. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity parturition G-protein coupled peptide receptor activity hormone-mediated signaling pathway membrane integral component of membrane cell differentiation extracellular matrix organization hormone binding metal ion binding lung connective tissue development nipple morphogenesis uc008pnv.1 uc008pnv.2 uc008pnv.3 
ENSMUST00000078528.7 C1qbp ENSMUST00000078528.7 complement component 1, q subcomponent binding protein (from RefSeq NM_007573.2) C1qbp ENSMUST00000078528.1 ENSMUST00000078528.2 ENSMUST00000078528.3 ENSMUST00000078528.4 ENSMUST00000078528.5 ENSMUST00000078528.6 NM_007573 Q8R5L1 Q8R5L1_MOUSE uc007jxf.1 uc007jxf.2 uc007jxf.3 Belongs to the MAM33 family. negative regulation of transcription from RNA polymerase II promoter complement component C1q binding transcription corepressor activity protein kinase C binding hyaluronic acid binding extracellular space nucleus cytoplasm mitochondrion mitochondrial matrix cytosol plasma membrane transcription factor binding cell surface phosphatidylinositol 3-kinase signaling membrane regulation of complement activation kininogen binding adrenergic receptor binding negative regulation of interferon-gamma production negative regulation of interleukin-12 production negative regulation of MDA-5 signaling pathway negative regulation of RIG-I signaling pathway mature ribosome assembly positive regulation of apoptotic process positive regulation of cell adhesion negative regulation of mRNA splicing, via spliceosome presynaptic active zone negative regulation of defense response to virus positive regulation of protein kinase B signaling positive regulation of neutrophil chemotaxis presynapse glutamatergic synapse GABA-ergic synapse positive regulation of substrate adhesion-dependent cell spreading positive regulation of trophoblast cell migration positive regulation of dendritic cell chemotaxis uc007jxf.1 uc007jxf.2 uc007jxf.3 
ENSMUST00000078531.2 Or8g32 ENSMUST00000078531.2 olfactory receptor family 8 subfamily G member 32 (from RefSeq NM_001011812.1) ENSMUST00000078531.1 NM_001011812 Olfr951 Or8g32 Q9EQ94 Q9EQ94_MOUSE uc009oxw.1 uc009oxw.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oxw.1 uc009oxw.2 
ENSMUST00000078532.3 Taar7a ENSMUST00000078532.3 trace amine-associated receptor 7A (from RefSeq NM_001010829.1) ENSMUST00000078532.1 ENSMUST00000078532.2 Gm229 NM_001010829 Q5QD12 TAA7A_MOUSE uc007eqj.1 uc007eqj.2 Orphan olfactory receptor specific for trace amines. Cell membrane ; Multi-pass membrane protein Specifically expressed in neurons of the olfactory epithelium. Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2- phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled amine receptor activity membrane integral component of membrane uc007eqj.1 uc007eqj.2 
ENSMUST00000078547.12 Sec22c ENSMUST00000078547.12 SEC22 homolog C, vesicle trafficking protein, transcript variant 1 (from RefSeq NM_178677.4) ENSMUST00000078547.1 ENSMUST00000078547.10 ENSMUST00000078547.11 ENSMUST00000078547.2 ENSMUST00000078547.3 ENSMUST00000078547.4 ENSMUST00000078547.5 ENSMUST00000078547.6 ENSMUST00000078547.7 ENSMUST00000078547.8 ENSMUST00000078547.9 NM_178677 Q8BMH4 Q8BXT9 Q8C0R8 SC22C_MOUSE Sec22l3 uc009sdm.1 uc009sdm.2 uc009sdm.3 uc009sdm.4 May be involved in vesicle transport between the ER and the Golgi complex. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the synaptobrevin family. endoplasmic reticulum endoplasmic reticulum membrane protein transport membrane integral component of membrane vesicle-mediated transport uc009sdm.1 uc009sdm.2 uc009sdm.3 uc009sdm.4 
ENSMUST00000078559.5 Clec4b1 ENSMUST00000078559.5 C-type lectin domain family 4, member b1, transcript variant 1 (from RefSeq NM_001190310.1) Aplra2 Clec4b Clec4b1 Dcar ENSMUST00000078559.1 ENSMUST00000078559.2 ENSMUST00000078559.3 ENSMUST00000078559.4 NM_001190310 Q7TS58 Q7TS58_MOUSE uc009dpz.1 uc009dpz.2 uc009dpz.3 uc009dpz.4 cell membrane integral component of membrane carbohydrate binding positive regulation of release of sequestered calcium ion into cytosol uc009dpz.1 uc009dpz.2 uc009dpz.3 uc009dpz.4 
ENSMUST00000078568.12 Slc9b1 ENSMUST00000078568.12 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1, transcript variant 1 (from RefSeq NM_028946.4) ENSMUST00000078568.1 ENSMUST00000078568.10 ENSMUST00000078568.11 ENSMUST00000078568.2 ENSMUST00000078568.3 ENSMUST00000078568.4 ENSMUST00000078568.5 ENSMUST00000078568.6 ENSMUST00000078568.7 ENSMUST00000078568.8 ENSMUST00000078568.9 G5E8I2 G5E8I2_MOUSE NM_028946 Nhedc1 Slc9b1 uc008rli.1 uc008rli.2 uc008rli.3 uc008rli.4 Membrane ; Multi- pass membrane protein Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. cation transport sodium ion transport solute:proton antiporter activity membrane integral component of membrane transmembrane transport hydrogen ion transmembrane transport uc008rli.1 uc008rli.2 uc008rli.3 uc008rli.4 
ENSMUST00000078588.2 Or14a256 ENSMUST00000078588.2 olfactory receptor family 14 subfamily A member 256 (from RefSeq NM_001011750.2) ENSMUST00000078588.1 F7CWV4 F7CWV4_MOUSE NM_001011750 Olfr294 Olfr304 Or14a256 uc009ife.1 uc009ife.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ife.1 uc009ife.2 
ENSMUST00000078605.7 Tcp11x2 ENSMUST00000078605.7 t-complex 11 family, X-linked 2 (from RefSeq NM_027952.3) 1700008I05Rik A2AEI7 A2AEI7_MOUSE ENSMUST00000078605.1 ENSMUST00000078605.2 ENSMUST00000078605.3 ENSMUST00000078605.4 ENSMUST00000078605.5 ENSMUST00000078605.6 NM_027952 Tcp11x2 uc009uhi.1 uc009uhi.2 uc009uhi.3 Belongs to the TCP11 family. molecular_function cellular_component biological_process uc009uhi.1 uc009uhi.2 uc009uhi.3 
ENSMUST00000078615.12 Tsbp1 ENSMUST00000078615.12 testis expressed basic protein 1, transcript variant 1 (from RefSeq NM_001001177.2) A2CG24 A2CG24_MOUSE BC051142 ENSMUST00000078615.1 ENSMUST00000078615.10 ENSMUST00000078615.11 ENSMUST00000078615.2 ENSMUST00000078615.3 ENSMUST00000078615.4 ENSMUST00000078615.5 ENSMUST00000078615.6 ENSMUST00000078615.7 ENSMUST00000078615.8 ENSMUST00000078615.9 NM_001001177 RP23-24A13.2-003 Tesb Tsbp1 uc008ccn.1 uc008ccn.2 uc008ccn.3 uc008ccn.4 molecular_function cellular_component biological_process membrane integral component of membrane uc008ccn.1 uc008ccn.2 uc008ccn.3 uc008ccn.4 
ENSMUST00000078623.5 Cryba1 ENSMUST00000078623.5 crystallin, beta A1, transcript variant 1 (from RefSeq NM_009965.3) Cryba1 ENSMUST00000078623.1 ENSMUST00000078623.2 ENSMUST00000078623.3 ENSMUST00000078623.4 NM_009965 Q9QXC6 Q9QXC6_MOUSE uc007khe.1 uc007khe.2 uc007khe.3 uc007khe.4 Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Crystallins are the dominant structural components of the vertebrate eye lens. Belongs to the beta/gamma-crystallin family. negative regulation of cytokine production lens development in camera-type eye nucleus cytoplasm visual perception negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of TOR signaling negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade positive regulation of anoikis uc007khe.1 uc007khe.2 uc007khe.3 uc007khe.4 
ENSMUST00000078626.8 Trank1 ENSMUST00000078626.8 tetratricopeptide repeat and ankyrin repeat containing 1 (from RefSeq NM_001164659.1) ENSMUST00000078626.1 ENSMUST00000078626.2 ENSMUST00000078626.3 ENSMUST00000078626.4 ENSMUST00000078626.5 ENSMUST00000078626.6 ENSMUST00000078626.7 Gm187 Kiaa0342 Lba1 NM_001164659 Q5RJH5 Q6ZQD5 Q8BV79 TRNK1_MOUSE uc009rvt.1 uc009rvt.2 uc009rvt.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BV79-1; Sequence=Displayed; Name=2; IsoId=Q8BV79-2; Sequence=VSP_035117; Expressed only in the brain. Detected in the hippocampus, hypothalamus and cingulate gyrus. molecular_function cellular_component biological_process uc009rvt.1 uc009rvt.2 uc009rvt.3 
ENSMUST00000078647.11 Rab43 ENSMUST00000078647.11 RAB43, member RAS oncogene family, transcript variant 1 (from RefSeq NM_001039394.1) ENSMUST00000078647.1 ENSMUST00000078647.10 ENSMUST00000078647.2 ENSMUST00000078647.3 ENSMUST00000078647.4 ENSMUST00000078647.5 ENSMUST00000078647.6 ENSMUST00000078647.7 ENSMUST00000078647.8 ENSMUST00000078647.9 NM_001039394 Q8CG50 RAB43_MOUSE uc009ctx.1 uc009ctx.2 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Interacts with GDI1, GDI2, CHM and CHML; phosphorylation at Thr-80 disrupts these interactions. Cytoplasmic vesicle, phagosome Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side Golgi apparatus Golgi apparatus, trans-Golgi network membrane ; Lipid-anchor Golgi apparatus, trans-Golgi network Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity GTP binding Golgi apparatus intracellular protein transport Golgi organization membrane virion assembly phagocytic vesicle membrane cytoplasmic vesicle Rab protein signal transduction retrograde transport, plasma membrane to Golgi phagocytic vesicle cellular response to interferon-gamma phagosome maturation toxin transport uc009ctx.1 uc009ctx.2 
ENSMUST00000078665.13 Dhps ENSMUST00000078665.13 deoxyhypusine synthase (from RefSeq NM_001039514.1) DHYS_MOUSE E9QM48 ENSMUST00000078665.1 ENSMUST00000078665.10 ENSMUST00000078665.11 ENSMUST00000078665.12 ENSMUST00000078665.2 ENSMUST00000078665.3 ENSMUST00000078665.4 ENSMUST00000078665.5 ENSMUST00000078665.6 ENSMUST00000078665.7 ENSMUST00000078665.8 ENSMUST00000078665.9 NM_001039514 Q3TXU5 uc009mpf.1 uc009mpf.2 uc009mpf.3 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. Reaction=[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]- deoxyhypusine + propane-1,3-diamine; Xref=Rhea:RHEA:33299, Rhea:RHEA- COMP:10143, Rhea:RHEA-COMP:10144, ChEBI:CHEBI:29969, ChEBI:CHEBI:57484, ChEBI:CHEBI:57834, ChEBI:CHEBI:82657; EC=2.5.1.46; Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence=; Protein modification; eIF5A hypusination. Belongs to the deoxyhypusine synthase family. cytoplasm spermidine metabolic process peptidyl-lysine modification to peptidyl-hypusine transferase activity deoxyhypusine synthase activity positive regulation of T cell proliferation glucose homeostasis identical protein binding spermidine catabolic process protein homotetramerization uc009mpf.1 uc009mpf.2 uc009mpf.3 
ENSMUST00000078673.14 Samd12 ENSMUST00000078673.14 sterile alpha motif domain containing 12 (from RefSeq NM_177225.4) ENSMUST00000078673.1 ENSMUST00000078673.10 ENSMUST00000078673.11 ENSMUST00000078673.12 ENSMUST00000078673.13 ENSMUST00000078673.2 ENSMUST00000078673.3 ENSMUST00000078673.4 ENSMUST00000078673.5 ENSMUST00000078673.6 ENSMUST00000078673.7 ENSMUST00000078673.8 ENSMUST00000078673.9 NM_177225 Q0VE29 SAM12_MOUSE uc007vri.1 uc007vri.2 uc007vri.3 molecular_function cellular_component biological_process uc007vri.1 uc007vri.2 uc007vri.3 
ENSMUST00000078676.6 Uqcrh ENSMUST00000078676.6 ubiquinol-cytochrome c reductase hinge protein (from RefSeq NM_025641.3) ENSMUST00000078676.1 ENSMUST00000078676.2 ENSMUST00000078676.3 ENSMUST00000078676.4 ENSMUST00000078676.5 NM_025641 P99028 Q542K2 Q9CQP4 QCR6_MOUSE uc008ufv.1 uc008ufv.2 uc008ufv.3 Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:19026783). Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side Belongs to the UQCRH/QCR6 family. mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex III mitochondrial electron transport, ubiquinol to cytochrome c ubiquinol-cytochrome-c reductase activity aerobic respiration membrane macromolecular complex binding protein heterooligomerization oxidation-reduction process respiratory chain uc008ufv.1 uc008ufv.2 uc008ufv.3 
ENSMUST00000078680.13 Ush1c ENSMUST00000078680.13 USH1 protein network component harmonin, transcript variant a1 (from RefSeq NM_023649.2) A0A0R4J0Z8 A0A0R4J0Z8_MOUSE ENSMUST00000078680.1 ENSMUST00000078680.10 ENSMUST00000078680.11 ENSMUST00000078680.12 ENSMUST00000078680.2 ENSMUST00000078680.3 ENSMUST00000078680.4 ENSMUST00000078680.5 ENSMUST00000078680.6 ENSMUST00000078680.7 ENSMUST00000078680.8 ENSMUST00000078680.9 NM_023649 Ush1c uc009gyh.1 uc009gyh.2 uc009gyh.3 uc009gyh.4 sensory perception of sound actin filament binding uc009gyh.1 uc009gyh.2 uc009gyh.3 uc009gyh.4 
ENSMUST00000078691.12 Bak1 ENSMUST00000078691.12 BCL2-antagonist/killer 1, transcript variant 1 (from RefSeq NM_007523.3) BAK_MOUSE Bak E9QM21 ENSMUST00000078691.1 ENSMUST00000078691.10 ENSMUST00000078691.11 ENSMUST00000078691.2 ENSMUST00000078691.3 ENSMUST00000078691.4 ENSMUST00000078691.5 ENSMUST00000078691.6 ENSMUST00000078691.7 ENSMUST00000078691.8 ENSMUST00000078691.9 NM_007523 O08734 Q8C264 uc008bff.1 uc008bff.2 uc008bff.3 In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2. Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2 and BCL2L1 isoform Bcl-X(L). Forms heterooligomers with BAX (By similarity). Interacts with BCL2A1 (PubMed:18462686). Interacts withRTL10/BOP (PubMed:18462686). Interacts with VDAC1 (By similarity). Interacts with GIMAP3/IAN4 and GIMAP5/IAN5 (PubMed:16509771). (Microbial infection) Interacts with gamma-herpesvirus 68 protein vBCL2. O08734; Q07440: Bcl2a1; NbExp=2; IntAct=EBI-822441, EBI-707754; O08734; P97287: Mcl1; NbExp=2; IntAct=EBI-822441, EBI-707292; O08734; Q80U63: Mfn2; NbExp=2; IntAct=EBI-822441, EBI-8437663; O08734; Q60930: Vdac2; NbExp=3; IntAct=EBI-822441, EBI-444578; O08734; O75460: ERN1; Xeno; NbExp=2; IntAct=EBI-822441, EBI-371750; Mitochondrion outer membrane ; Single-pass membrane protein Widely expressed. Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti- apoptotic members of the Bcl-2 family. Belongs to the Bcl-2 family. Sequence=CAA73684.1; Type=Frameshift; leukocyte homeostasis B cell homeostasis B cell apoptotic process release of cytochrome c from mitochondria blood vessel remodeling myeloid cell homeostasis B cell negative selection protein binding mitochondrion mitochondrial outer membrane endoplasmic reticulum cytosol apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process brain development aging mitochondrial fusion cell proliferation negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c response to fungus response to mycotoxin response to UV-C establishment or maintenance of transmembrane electrochemical gradient response to gamma radiation positive regulation of calcium ion transport into cytosol negative regulation of gene expression response to organic cyclic compound membrane integral component of membrane viral process endocrine pancreas development heat shock protein binding animal organ regeneration integral component of mitochondrial outer membrane mitochondrial membrane negative regulation of endoplasmic reticulum calcium ion concentration negative regulation of peptidyl-serine phosphorylation cellular response to UV limb morphogenesis response to drug response to hydrogen peroxide identical protein binding protein homodimerization activity regulation of apoptotic process positive regulation of apoptotic process regulation of protein homodimerization activity regulation of protein heterodimerization activity ion channel binding fibroblast apoptotic process response to ethanol positive regulation of proteolysis metal ion binding regulation of mitochondrial membrane permeability pore complex protein heterodimerization activity post-embryonic camera-type eye morphogenesis homeostasis of number of cells chaperone binding BH domain binding regulation of cell cycle regulation of mitochondrial membrane potential vagina development intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress thymocyte apoptotic process cellular response to mechanical stimulus positive regulation of release of cytochrome c from mitochondria Bcl-2 family protein complex BAK complex apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand activation of cysteine-type endopeptidase activity positive regulation of endoplasmic reticulum unfolded protein response apoptotic process involved in blood vessel morphogenesis uc008bff.1 uc008bff.2 uc008bff.3 
ENSMUST00000078694.13 Ppp1r1b ENSMUST00000078694.13 protein phosphatase 1, regulatory inhibitor subunit 1B, transcript variant 1 (from RefSeq NM_144828.2) A2A564 ENSMUST00000078694.1 ENSMUST00000078694.10 ENSMUST00000078694.11 ENSMUST00000078694.12 ENSMUST00000078694.2 ENSMUST00000078694.3 ENSMUST00000078694.4 ENSMUST00000078694.5 ENSMUST00000078694.6 ENSMUST00000078694.7 ENSMUST00000078694.8 ENSMUST00000078694.9 NM_144828 PPR1B_MOUSE Q3URF2 Q60829 Q6DV86 Q91XB5 uc007lfz.1 uc007lfz.2 uc007lfz.3 uc007lfz.4 This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders in humans. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Inhibitor of protein-phosphatase 1. Cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60829-1; Sequence=Displayed; Name=2; Synonyms=DARPP-30; IsoId=Q60829-2; Sequence=VSP_025058; Dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Phosphorylation of Thr-34 is required for activity. Belongs to the protein phosphatase inhibitor 1 family. response to amphetamine protein phosphatase inhibitor activity protein serine/threonine phosphatase inhibitor activity nucleus cytoplasm transcription, DNA-templated signal transduction memory negative regulation of female receptivity locomotory behavior visual learning D1 dopamine receptor binding D2 dopamine receptor binding D3 dopamine receptor binding D4 dopamine receptor binding D5 dopamine receptor binding negative regulation of phosphoprotein phosphatase activity response to nicotine intracellular signal transduction response to cocaine neuronal cell body response to morphine dendritic spine neck dendritic spine head behavioral response to cocaine postsynapse glutamatergic synapse uc007lfz.1 uc007lfz.2 uc007lfz.3 uc007lfz.4 
ENSMUST00000078695.5 Pramel24 ENSMUST00000078695.5 PRAME like 24 (from RefSeq NM_001085412.2) A2AGW8 A2AGW8_MOUSE ENSMUST00000078695.1 ENSMUST00000078695.2 ENSMUST00000078695.3 ENSMUST00000078695.4 NM_001085412 Pramel24 uc008vqk.1 uc008vqk.2 uc008vqk.3 uc008vqk.4 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vqk.1 uc008vqk.2 uc008vqk.3 uc008vqk.4 
ENSMUST00000078710.2 Or52e8 ENSMUST00000078710.2 olfactory receptor family 52 subfamily E member 8 (from RefSeq NM_001011755.1) ENSMUST00000078710.1 NM_001011755 Olfr671 Or52e8 Q7TRP2 Q7TRP2_MOUSE uc009ixh.1 uc009ixh.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ixh.1 uc009ixh.2 
ENSMUST00000078717.7 Lrrc58 ENSMUST00000078717.7 leucine rich repeat containing 58 (from RefSeq NM_177093.3) B2RU81 ENSMUST00000078717.1 ENSMUST00000078717.2 ENSMUST00000078717.3 ENSMUST00000078717.4 ENSMUST00000078717.5 ENSMUST00000078717.6 LRC58_MOUSE NM_177093 Q3UGP9 Q8BX06 uc007zek.1 uc007zek.2 uc007zek.3 molecular_function cellular_component biological_process uc007zek.1 uc007zek.2 uc007zek.3 
ENSMUST00000078719.13 Enah ENSMUST00000078719.13 ENAH actin regulator, transcript variant 1 (from RefSeq NM_010135.4) E9QLZ9 E9QLZ9_MOUSE ENSMUST00000078719.1 ENSMUST00000078719.10 ENSMUST00000078719.11 ENSMUST00000078719.12 ENSMUST00000078719.2 ENSMUST00000078719.3 ENSMUST00000078719.4 ENSMUST00000078719.5 ENSMUST00000078719.6 ENSMUST00000078719.7 ENSMUST00000078719.8 ENSMUST00000078719.9 Enah NM_010135 uc007dxq.1 uc007dxq.2 uc007dxq.3 uc007dxq.4 uc007dxq.5 Cytoplasm, cytoskeleton Belongs to the Ena/VASP family. cytosol plasma membrane focal adhesion cell junction WW domain binding uc007dxq.1 uc007dxq.2 uc007dxq.3 uc007dxq.4 uc007dxq.5 
ENSMUST00000078748.4 Slc10a5 ENSMUST00000078748.4 solute carrier family 10 (sodium/bile acid cotransporter family), member 5 (from RefSeq NM_001010834.2) B9EJ85 ENSMUST00000078748.1 ENSMUST00000078748.2 ENSMUST00000078748.3 Gm405 NM_001010834 NTCP5_MOUSE Q5PT54 uc008opr.1 uc008opr.2 Membrane ; Multi-pass membrane protein Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. ion transport sodium ion transport bile acid:sodium symporter activity symporter activity bile acid and bile salt transport membrane integral component of membrane transmembrane transport uc008opr.1 uc008opr.2 
ENSMUST00000078752.10 Golm2 ENSMUST00000078752.10 golgi membrane protein 2, transcript variant 5 (from RefSeq NM_001205371.1) A2AR57 Casc4 ENSMUST00000078752.1 ENSMUST00000078752.2 ENSMUST00000078752.3 ENSMUST00000078752.4 ENSMUST00000078752.5 ENSMUST00000078752.6 ENSMUST00000078752.7 ENSMUST00000078752.8 ENSMUST00000078752.9 GOLM2_MOUSE Golm2 NM_001205371 Q6P2L7 Q6RZW5 Q6RZW6 Q8C4Z2 uc008lzr.1 uc008lzr.2 uc008lzr.3 uc008lzr.4 Membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P2L7-1; Sequence=Displayed; Name=2; IsoId=Q6P2L7-2; Sequence=VSP_026263; Name=3; IsoId=Q6P2L7-3; Sequence=VSP_026263, VSP_026264, VSP_026265; Belongs to the GOLM family. Sequence=AAR26705.1; Type=Frameshift; Evidence=; molecular_function Golgi apparatus biological_process membrane integral component of membrane uc008lzr.1 uc008lzr.2 uc008lzr.3 uc008lzr.4 
ENSMUST00000078756.7 H2ac18 ENSMUST00000078756.7 H2A clustered histone 18 (from RefSeq NM_013549.3) ENSMUST00000078756.1 ENSMUST00000078756.2 ENSMUST00000078756.3 ENSMUST00000078756.4 ENSMUST00000078756.5 ENSMUST00000078756.6 H2A2A_MOUSE Hist2h2aa1 Hist2h2aa2 NM_013549 P20670 Q6GSS7 Q811M3 uc057lgd.1 uc057lgd.2 uc057lgd.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Oct 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: CN834202.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization nucleosome assembly protein heterodimerization activity uc057lgd.1 uc057lgd.2 uc057lgd.3 
ENSMUST00000078757.8 Gal3st1 ENSMUST00000078757.8 galactose-3-O-sulfotransferase 1, transcript variant 2 (from RefSeq NM_001177703.1) Cst ENSMUST00000078757.1 ENSMUST00000078757.2 ENSMUST00000078757.3 ENSMUST00000078757.4 ENSMUST00000078757.5 ENSMUST00000078757.6 ENSMUST00000078757.7 G3ST1_MOUSE Gal3st1 Gcst NM_001177703 Q9D8V6 Q9JHE4 uc007huc.1 uc007huc.2 uc007huc.3 uc007huc.4 Catalyzes the transfer of a sulfate group to position 3 of non-reducing beta-galactosyl residues in glycerolipids and sphingolipids, therefore participates in the biosynthesis of sulfoglycolipids (PubMed:11917099). Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (PubMed:11917099). Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) (By similarity). Reaction=3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N- acylsphing-4-enine = adenosine 3',5'-bisphosphate + H(+) + N-acyl-1- beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine; Xref=Rhea:RHEA:20613, ChEBI:CHEBI:15378, ChEBI:CHEBI:18390, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:75956; EC=2.8.2.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20614; Evidence=; Reaction=3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D- galactosyl)-sn-glycerol = a 1-O-alkyl-2-acyl-3-(beta-D-3- sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:41744, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:78428, ChEBI:CHEBI:78429; EC=2.8.2.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41745; Evidence=; Reaction=3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer = 1-(3-O- sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:43304, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:82953, ChEBI:CHEBI:143593; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43305; Evidence=; Reaction=3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D- galactosyl)-sn-glycerol = 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)- sn-glycerol + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:41748, ChEBI:CHEBI:15378, ChEBI:CHEBI:17615, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:157618; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41749; Evidence=; Reaction=3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc- (1<->1)-Cer(d18:1(4E)) = adenosine 3',5'-bisphosphate + beta-D-3- sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+); Xref=Rhea:RHEA:41736, ChEBI:CHEBI:15378, ChEBI:CHEBI:17950, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:78426; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41737; Evidence=; Lipid metabolism; sphingolipid metabolism. Golgi apparatus membrane ; Single- pass type II membrane protein Expressed in brain, testis, kidney, stomach, small intestine, liver, and lung. Not detected in heart, skeletal muscle, and spleen. Mice homozygous for a null mutation of the CST gene born healthy and display hindlimb weakness from week 6 of age and subsequently show a prenounced tremor and progressive ataxia. Myelin vacuolation is observed in the cerebellar white matter, diencephalon, brainstem and spinal anterior column. Male mice were infertile due to a blocked spermatogenesis. Belongs to the galactose-3-O-sulfotransferase family. Golgi membrane galactosylceramide sulfotransferase activity Golgi apparatus lipid metabolic process sphingolipid metabolic process galactosylceramide biosynthetic process spermatogenesis glycolipid biosynthetic process membrane integral component of membrane transferase activity myelination uc007huc.1 uc007huc.2 uc007huc.3 uc007huc.4 
ENSMUST00000078770.5 Ms4a19 ENSMUST00000078770.5 membrane-spanning 4-domains, subfamily A, member 19, transcript variant 2 (from RefSeq NM_027074.4) 1700025F22Rik ENSMUST00000078770.1 ENSMUST00000078770.2 ENSMUST00000078770.3 ENSMUST00000078770.4 Ms4a19 NM_027074 Q9D9Y7 Q9D9Y7_MOUSE uc008grs.1 uc008grs.2 uc008grs.3 molecular_function cellular_component biological_process membrane integral component of membrane uc008grs.1 uc008grs.2 uc008grs.3 
ENSMUST00000078775.13 Xlr4a ENSMUST00000078775.13 X-linked lymphocyte-regulated 4A (from RefSeq NM_001081642.1) A2BI40 A2BI40_MOUSE ENSMUST00000078775.1 ENSMUST00000078775.10 ENSMUST00000078775.11 ENSMUST00000078775.12 ENSMUST00000078775.2 ENSMUST00000078775.3 ENSMUST00000078775.4 ENSMUST00000078775.5 ENSMUST00000078775.6 ENSMUST00000078775.7 ENSMUST00000078775.8 ENSMUST00000078775.9 NM_001081642 Xlr4a uc009tlb.1 uc009tlb.2 uc009tlb.3 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc009tlb.1 uc009tlb.2 uc009tlb.3 
ENSMUST00000078800.13 Nfya ENSMUST00000078800.13 nuclear transcription factor-Y alpha, transcript variant 10 (from RefSeq NM_001413338.1) ENSMUST00000078800.1 ENSMUST00000078800.10 ENSMUST00000078800.11 ENSMUST00000078800.12 ENSMUST00000078800.2 ENSMUST00000078800.3 ENSMUST00000078800.4 ENSMUST00000078800.5 ENSMUST00000078800.6 ENSMUST00000078800.7 ENSMUST00000078800.8 ENSMUST00000078800.9 NFYA_MOUSE NM_001413338 P23708 uc008cxp.1 uc008cxp.2 uc008cxp.3 uc008cxp.4 Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component BMAL1. Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding (By similarity). Interacts with SP1; the interaction is inhibited by glycosylation of SP1. Interacts (via N-terminus) with ZHX2 (via homeobox domain). Interacts with ZFX3. Interacts with ZHX1 (By similarity). P23708; P08047: SP1; Xeno; NbExp=18; IntAct=EBI-862337, EBI-298336; Nucleus. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P23708-1; Sequence=Displayed; Name=Short; IsoId=P23708-2; Sequence=VSP_000850; Belongs to the NFYA/HAP2 subunit family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated transcription factor binding CCAAT-binding factor complex protein-DNA complex sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process RNA polymerase II transcription factor complex regulation of stem cell population maintenance positive regulation of stem cell proliferation RNA polymerase II distal enhancer sequence-specific DNA binding transcription regulatory region DNA binding uc008cxp.1 uc008cxp.2 uc008cxp.3 uc008cxp.4 
ENSMUST00000078803.5 Vps28 ENSMUST00000078803.5 vacuolar protein sorting 28, transcript variant 1 (from RefSeq NM_025842.4) ENSMUST00000078803.1 ENSMUST00000078803.2 ENSMUST00000078803.3 ENSMUST00000078803.4 NM_025842 Q9D1C8 VPS28_MOUSE uc007wlc.1 uc007wlc.2 uc007wlc.3 uc007wlc.4 This gene encodes a protein which is thought to be a subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]. Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS37B, VPS37C, MVB12A and MVB12B. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with VPS36; the interaction mediates the association with the ESCRT-II complex. Interacts with SNF8 and VPS25. Interacts with CEP55 (By similarity). Q9D1C8; O54788: Dffb; NbExp=6; IntAct=EBI-309205, EBI-7365197; Q9D1C8; O35099: Map3k5; NbExp=3; IntAct=EBI-309205, EBI-777493; Q9D1C8; Q99683: MAP3K5; Xeno; NbExp=5; IntAct=EBI-309205, EBI-476263; Cell membrane Late endosome membrane ; Peripheral membrane protein Belongs to the VPS28 family. ESCRT I complex protein binding cytoplasm endosome early endosome cytosol plasma membrane endosome membrane protein transport membrane negative regulation of protein ubiquitination late endosome membrane endosome transport via multivesicular body sorting pathway ubiquitin binding ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway macromolecular complex binding positive regulation of protein catabolic process positive regulation of ubiquitin-dependent endocytosis uc007wlc.1 uc007wlc.2 uc007wlc.3 uc007wlc.4 
ENSMUST00000078804.12 Rpl35a ENSMUST00000078804.12 ribosomal protein L35A, transcript variant 3 (from RefSeq NM_001130485.1) ENSMUST00000078804.1 ENSMUST00000078804.10 ENSMUST00000078804.11 ENSMUST00000078804.2 ENSMUST00000078804.3 ENSMUST00000078804.4 ENSMUST00000078804.5 ENSMUST00000078804.6 ENSMUST00000078804.7 ENSMUST00000078804.8 ENSMUST00000078804.9 NM_001130485 Q6ZWX1 Q6ZWX1_MOUSE Rpl35a uc007yzu.1 uc007yzu.2 uc007yzu.3 uc007yzu.4 Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL33 family. structural constituent of ribosome ribosome rRNA processing translation ribosomal large subunit biogenesis uc007yzu.1 uc007yzu.2 uc007yzu.3 uc007yzu.4 
ENSMUST00000078816.5 Zfp696 ENSMUST00000078816.5 RIKEN cDNA 9130023H24 gene (from RefSeq NM_177001.3) 9130023H24Rik ENSMUST00000078816.1 ENSMUST00000078816.2 ENSMUST00000078816.3 ENSMUST00000078816.4 NM_177001 Q8BG98 Q8BG98_MOUSE uc009jyj.1 uc009jyj.2 uc009jyj.3 uc009jyj.4 Nucleus nucleic acid binding DNA binding nucleus uc009jyj.1 uc009jyj.2 uc009jyj.3 uc009jyj.4 
ENSMUST00000078825.5 Fcgr4 ENSMUST00000078825.5 Fc receptor, IgG, low affinity IV (from RefSeq NM_144559.2) A0A0B4J1G0 ENSMUST00000078825.1 ENSMUST00000078825.2 ENSMUST00000078825.3 ENSMUST00000078825.4 FCG3A_MOUSE Fcgr3a Fcgr4 NM_144559 Q3TC44 Q8R2R4 Q8R477 uc007dmw.1 uc007dmw.2 uc007dmw.3 uc007dmw.4 Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (PubMed:16039578). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417). Can bind to IgG2a and IgG2b monomers (PubMed:18949059). Does not display binding to IgG1 or IgG3 (PubMed:16039578). Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC). Confers protection to lethal influenza virus infection (PubMed:24412922). On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses (PubMed:28389502). Mediates neutrophil activation by IgG complexes redundantly with FCGR2A (PubMed:18097064). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719). Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE) (PubMed:17558411, PubMed:18949059). Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059). Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411). Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059). Binding to IgE promotes macrophage- mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821). Forms a heterooligomeric complex with ITAM-containing signaling subunits FCER1G. Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction. Binds the Fc region of antigen-complexed IgG. Cell membrane ingle-pass type I membrane protein Detected on myeloid cells, peripheral blood monocytes, splenic and bone marrow dendritic cells, and thioglycollate- elicited macrophages and neutrophils but absent from lymphoid populations with no expression observed on T cells, B cells, NK cells or other granulocytes (at protein level) (PubMed:16039578, PubMed:19795417). Expressed in peripheral blood leukocytes, spleen, liver, thymus and small intestine (PubMed:12389094, PubMed:17558411). Expressed in splenic dendritic cell subsets (at protein level). By lipopolysaccharide, interferon beta and IFNG. N-glycosylated. Phosphorylated following receptor ligation. plasma membrane external side of plasma membrane cell surface membrane integral component of membrane IgE receptor activity IgG receptor activity IgE binding IgG binding Fc-gamma receptor signaling pathway Fc-epsilon receptor signaling pathway wound healing neutrophil activation positive regulation of bone resorption regulation of sensory perception of pain cellular response to lipopolysaccharide uc007dmw.1 uc007dmw.2 uc007dmw.3 uc007dmw.4 
ENSMUST00000078827.3 Csprs ENSMUST00000078827.3 component of Sp100-rs (from RefSeq NM_033616.4) Csprs ENSMUST00000078827.1 ENSMUST00000078827.2 NM_033616 Q8BYZ8 Q8BYZ8_MOUSE uc009oae.1 uc009oae.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity G-protein coupled receptor signaling pathway membrane integral component of membrane uc009oae.1 uc009oae.2 
ENSMUST00000078832.5 1700084M14Rik ENSMUST00000078832.5 RIKEN cDNA 1700084M14 gene (from RefSeq NR_126536.1) 1700084M14Rik B1AT01 B1AT01_MOUSE ENSMUST00000078832.1 ENSMUST00000078832.2 ENSMUST00000078832.3 ENSMUST00000078832.4 NR_126536 uc009tsj.1 uc009tsj.2 uc009tsj.3 uc009tsj.4 uc009tsj.5 molecular_function cellular_component biological_process uc009tsj.1 uc009tsj.2 uc009tsj.3 uc009tsj.4 uc009tsj.5 
ENSMUST00000078835.3 Klk1b1 ENSMUST00000078835.3 kallikrein 1-related peptidase b1 (from RefSeq NM_010645.3) ENSMUST00000078835.1 ENSMUST00000078835.2 K1KB1_MOUSE Klk-1 Klk1 NM_010645 P00755 uc009goc.1 uc009goc.2 uc009goc.3 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK089370.1, BC026378.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Reaction=Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl- bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|- Xaa.; EC=3.4.21.35; Belongs to the peptidase S1 family. Kallikrein subfamily. tissue kallikrein-kinin cascade bradykinin biosynthetic process regulation of systemic arterial blood pressure left ventricular cardiac muscle tissue morphogenesis endopeptidase activity serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides secretory granule zymogen activation macromolecular complex vasodilation cardiac muscle contraction uc009goc.1 uc009goc.2 uc009goc.3 
ENSMUST00000078856.8 Kl ENSMUST00000078856.8 klotho (from RefSeq NM_013823.2) B2RR78 ENSMUST00000078856.1 ENSMUST00000078856.2 ENSMUST00000078856.3 ENSMUST00000078856.4 ENSMUST00000078856.5 ENSMUST00000078856.6 ENSMUST00000078856.7 KLOT_MOUSE NM_013823 O35082 O70175 O70621 uc009aul.1 uc009aul.2 uc009aul.3 May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane- bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. Reaction=a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate; Xref=Rhea:RHEA:17633, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:58720, ChEBI:CHEBI:83411; EC=3.2.1.31; Evidence=; Inhibited by D-saccharic acid 1,4-lactone and taurocholic acid. Kinetic parameters: KM=0.249 mM for 4-methylumbelliferylglucuronide ; KM=0.251 mM for estrone 3-beta-D-glucuronide ; KM=0.174 mM for beta-estradiol 3-beta-D-glucuronide ; KM=0.251 mM for estriol 3-beta-D-glucuronide ; Vmax=0.62 uM/h/ug enzyme ; pH dependence: Optimum pH is 5.5. ; Homodimer. Interacts with FGF23 and FGFR1. O35082; P16092: Fgfr1; NbExp=2; IntAct=EBI-1570828, EBI-7953898; O35082; Q61851-1: Fgfr3; NbExp=2; IntAct=EBI-1570828, EBI-15820536; O35082; Q03142: Fgfr4; NbExp=2; IntAct=EBI-1570828, EBI-15633599; O35082; P04426: Wnt1; NbExp=2; IntAct=EBI-1570828, EBI-1570911; O35082; P17553: Wnt3; NbExp=4; IntAct=EBI-1570828, EBI-1570853; O35082; P22724: Wnt4; NbExp=2; IntAct=EBI-1570828, EBI-1570945; O35082; P22725: Wnt5a; NbExp=2; IntAct=EBI-1570828, EBI-1570983; O35082; Q9GZV9: FGF23; Xeno; NbExp=5; IntAct=EBI-1570828, EBI-6594125; O35082; P11362: FGFR1; Xeno; NbExp=2; IntAct=EBI-1570828, EBI-1028277; O35082; P11362-7: FGFR1; Xeno; NbExp=3; IntAct=EBI-1570828, EBI-15609945; [Isoform 1]: Cell membrane ingle-pass type I membrane protein Apical cell membrane ; Single-pass type I membrane protein Note=Isoform 1 shedding leads to a soluble peptide. [Isoform 2]: Secreted [Klotho peptide]: Secreted Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Membrane-bound; IsoId=O35082-1; Sequence=Displayed; Name=2; Synonyms=Secreted; IsoId=O35082-2; Sequence=VSP_015828, VSP_015829; Membrane-bound protein is present in distal renal tubules, inner ear, ependymal cells of brain choroid plexus, elongating spermatids and mature oocytes (at protein level). Soluble peptide is present in serum (100 pM) and cerebrospinal fluid. Expressed strongly in kidney, moderately in brain choroid plexus, and at low levels in pituitary, placenta, skeletal muscle, urinary bladder, aorta, pancreas, testis, ovary, colon, thyroid gland and adipocytes. Not expressed in the embryo. Expressed in the kidney of newborns. Induced by 1,25-dihydroxyvitamin D(3) in kidney. Down- regulated by angiotensin II and up-regulated by statins through modulation of the RhoA pathway in epithelial cells (in vitro). Isoform 1 (but not isoform 2) is up-regulated by thyroid hormone in adipocytes. Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 241, and the second one lacks the essential Glu active site residue at position 874. N-glycosylated. Mice display a syndrome resembling to human aging, with short lifespan, infertility, atherosclerosis, skin atrophy, osteoporosis and emphysema. They have various metabolic abnormalities, including increased insulin sensitivity and decreased insulin production. Mice overexpressing Kl have increased resistance to insulin and IGF1, a lifespan extended of more than 20%, and generate fewer offspring. [Isoform 1]: Predominates over the secreted form by more than 10 times in all tissues examined. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. Name=Protein Spotlight; Note=The thread of life - Issue 65 of December 2005; URL="https://web.expasy.org/spotlight/back_issues/065"; acute inflammatory response negative regulation of systemic arterial blood pressure hydrolase activity, hydrolyzing O-glycosyl compounds beta-glucuronidase activity fibroblast growth factor receptor binding protein binding extracellular region extracellular space plasma membrane carbohydrate metabolic process energy reserve metabolic process aging metabolic process insulin receptor signaling pathway beta-glucosidase activity fibroblast growth factor receptor signaling pathway membrane integral component of membrane apical plasma membrane hydrolase activity hydrolase activity, acting on glycosyl bonds fibroblast growth factor binding positive regulation of bone mineralization norepinephrine biosynthetic process calcium ion homeostasis positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway uc009aul.1 uc009aul.2 uc009aul.3 
ENSMUST00000078861.3 Or7g18 ENSMUST00000078861.3 olfactory receptor family 7 subfamily G member 18 (from RefSeq NM_146566.1) ENSMUST00000078861.1 ENSMUST00000078861.2 NM_146566 Olfr830 Or7g18 Q8VFJ5 Q8VFJ5_MOUSE uc009ogz.1 uc009ogz.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ogz.1 uc009ogz.2 
ENSMUST00000078869.6 Serpina1d ENSMUST00000078869.6 serine (or cysteine) peptidase inhibitor, clade A, member 1D (from RefSeq NM_009246.3) A1AT4_MOUSE Dom4 ENSMUST00000078869.1 ENSMUST00000078869.2 ENSMUST00000078869.3 ENSMUST00000078869.4 ENSMUST00000078869.5 NM_009246 Q00897 Spi1-4 uc007owg.1 uc007owg.2 uc007owg.3 Inhibitor of serine proteases. Can inhibit trypsin and chymotrypsin; relatively ineffective against elastase. Secreted The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin- protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity. Murine alpha-1-antitrypsin is represented by a cluster of up to 6 individual Serpina1-related genes. The precise complement of Serpina1-related genes present varies according to the strain of the animal. Belongs to the serpin family. protease binding endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity extracellular region extracellular space endoplasmic reticulum Golgi apparatus negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to cytokine identical protein binding intracellular membrane-bounded organelle response to peptide hormone uc007owg.1 uc007owg.2 uc007owg.3 
ENSMUST00000078874.14 Mpp4 ENSMUST00000078874.14 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4), transcript variant 2 (from RefSeq NM_145143.3) Dlg6 ENSMUST00000078874.1 ENSMUST00000078874.10 ENSMUST00000078874.11 ENSMUST00000078874.12 ENSMUST00000078874.13 ENSMUST00000078874.2 ENSMUST00000078874.3 ENSMUST00000078874.4 ENSMUST00000078874.5 ENSMUST00000078874.6 ENSMUST00000078874.7 ENSMUST00000078874.8 ENSMUST00000078874.9 MPP4_MOUSE NM_145143 Q0VG45 Q6P7F1 Q8BTT3 Q8BXM5 Q920P7 Q920P8 uc007bdi.1 uc007bdi.2 uc007bdi.3 May play a role in retinal photoreceptors development. May interact with GRIA2 (By similarity). Interacts with MPDZ. Forms a complex with CRB1 and PALS1. Interacts with FASLG (By similarity). Cytoplasm te=Localized at photoreceptor synaptic terminals in retina. Localized in rod and cone photoreceptors at the plasma membrane and at membranes of intracellular vesicles around the subapical region (SAR) and adherens junction, and in the outer plexiform layer (OPL). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=mDLG6A; IsoId=Q6P7F1-1; Sequence=Displayed; Name=3; Synonyms=mDLG6B; IsoId=Q6P7F1-3; Sequence=VSP_013995; Name=4; IsoId=Q6P7F1-4; Sequence=VSP_013994, VSP_013995, VSP_013996, VSP_013997; Detected in the retina (at protein level). Highly enriched in the retina where it is mainly expressed by rod photoreceptors; detected in the inner segment of the photoreceptor layer and in the outer nuclear layer. Also detected at much lower levels in pineal gland, cerebellum, cortex, hippocampus, olfactory bulb, heart, liver and spleen. Expressed in the CA1-CA3 regions of pyramidal cell layers and in the granule cell layer of dentate gyrus in the hippocampus. In the cerebellum, expressed in Purkinje cells and throughout the granule cell layer. In the olfactory bulb, expressed in mitral cells. Expressed postnatally in the retina. The expression in the retina coincides with one of the photoreceptor specific genes. Expressed in forebrain of 9.5 dpc embryos and in whole brain of 11.5 dpc embryos. Belongs to the MAGUK family. Sequence=AAH61694.2; Type=Erroneous initiation; Evidence=; Sequence=AAI16724.1; Type=Erroneous initiation; Evidence=; Sequence=BAB69494.1; Type=Erroneous initiation; Evidence=; Sequence=BAB69495.1; Type=Erroneous initiation; Evidence=; Sequence=BAC32031.1; Type=Frameshift; Evidence=; Sequence=BAC40562.1; Type=Frameshift; Evidence=; Sequence=BAC40562.1; Type=Miscellaneous discrepancy; Note=Frameshifts and sequencing errors.; Evidence=; Golgi membrane receptor binding cytoplasm cytosol cell-cell adherens junction actin cytoskeleton lateral plasma membrane macromolecular complex protein localization to synapse presynaptic membrane cone cell pedicle rod spherule basal part of cell uc007bdi.1 uc007bdi.2 uc007bdi.3 
ENSMUST00000078879.7 Defb50 ENSMUST00000078879.7 defensin beta 50 (from RefSeq NM_199067.2) DFB50_MOUSE Defb37 ENSMUST00000078879.1 ENSMUST00000078879.2 ENSMUST00000078879.3 ENSMUST00000078879.4 ENSMUST00000078879.5 ENSMUST00000078879.6 NM_199067 Pbd1 Q30KM7 Q6TU36 uc009lbz.1 uc009lbz.2 Has bactericidal activity. Secreted Highly expressed in prostate. Not expressed in uterus, epididymis, ovary, testis, spleen, submaxillary gland, thymus, thyroid, pancreas, smooth muscle, skeletal muscle, heart, kidney, lung, liver, eye and brain. Belongs to the beta-defensin family. molecular_function cellular_component extracellular region defense response biological_process defense response to bacterium uc009lbz.1 uc009lbz.2 
ENSMUST00000078880.6 Sorcs3 ENSMUST00000078880.6 sortilin-related VPS10 domain containing receptor 3 (from RefSeq NM_025696.3) ENSMUST00000078880.1 ENSMUST00000078880.2 ENSMUST00000078880.3 ENSMUST00000078880.4 ENSMUST00000078880.5 NM_025696 Q8VI51 Q9CTR4 SORC3_MOUSE uc008hvx.1 uc008hvx.2 Membrane; Single-pass type I membrane protein. Belongs to the VPS10-related sortilin family. SORCS subfamily. protein binding learning memory postsynaptic density membrane integral component of membrane glutamatergic synapse integral component of postsynaptic density membrane regulation of long term synaptic depression uc008hvx.1 uc008hvx.2 
ENSMUST00000078897.4 ENSMUSG00000121303 ENSMUST00000078897.4 ENSMUSG00000121303 (from geneSymbol) AK007298 ENSMUST00000078897.1 ENSMUST00000078897.2 ENSMUST00000078897.3 uc009goa.1 uc009goa.2 uc009goa.3 uc009goa.4 uc009goa.1 uc009goa.2 uc009goa.3 uc009goa.4 
ENSMUST00000078912.7 Ampd2 ENSMUST00000078912.7 adenosine monophosphate deaminase 2, transcript variant 4 (from RefSeq NM_001346665.1) A2AE27 A2AE28 AMPD2_MOUSE Ampd2 ENSMUST00000078912.1 ENSMUST00000078912.2 ENSMUST00000078912.3 ENSMUST00000078912.4 ENSMUST00000078912.5 ENSMUST00000078912.6 NM_001346665 Q91YI2 Q9DBT5 uc057lgj.1 uc057lgj.2 uc057lgj.3 AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14778; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. Homotetramer. Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q9DBT5-2; Sequence=Displayed; Name=1; IsoId=Q9DBT5-1; Sequence=VSP_061947; Mice have normal brain histology. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Sequence=AAH16662.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; AMP deaminase activity cytosol IMP biosynthetic process nucleotide metabolic process purine ribonucleoside monophosphate biosynthetic process hydrolase activity deaminase activity IMP salvage cholesterol homeostasis AMP metabolic process ATP metabolic process GTP metabolic process metal ion binding cyclic purine nucleotide metabolic process glomerular visceral epithelial cell development energy homeostasis uc057lgj.1 uc057lgj.2 uc057lgj.3 
ENSMUST00000078944.13 Phf6 ENSMUST00000078944.13 PHD finger protein 6, transcript variant 1 (from RefSeq NM_027642.2) ENSMUST00000078944.1 ENSMUST00000078944.10 ENSMUST00000078944.11 ENSMUST00000078944.12 ENSMUST00000078944.2 ENSMUST00000078944.3 ENSMUST00000078944.4 ENSMUST00000078944.5 ENSMUST00000078944.6 ENSMUST00000078944.7 ENSMUST00000078944.8 ENSMUST00000078944.9 Kiaa1823 NM_027642 PHF6_MOUSE Q80T86 Q8BYT8 Q8C1B5 Q9D4J7 uc009tep.1 uc009tep.2 uc009tep.3 uc009tep.4 Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. Interacts with UBTF. Interacts with the NuRD complex component RBBP4 (via the nucleolar localization motif), the interaction mediates transcriptional repression activity (By similarity). Nucleus Nucleus, nucleolus Chromosome, centromere, kinetochore Note=Nuclear, it particularly localizes to the nucleolus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D4J7-1; Sequence=Displayed; Name=2; IsoId=Q9D4J7-2; Sequence=VSP_009375; At 12.5 dpc it is highly expressed in the embryonic central nervous system and at lower levels in other tissues. Very low levels present throughout the adult brain. Expression is high in the embryonic and early postnatal stages. The PHD-type zinc finger 1 mediates both nucleolar localization and interaction with UBTF. The ePHD2 domain folds as an integrated structural module comprizing the C2HC pre-PHD-type 2 zinc finger and the PHD-type 2 zinc finger. It mediates non-specific binding to dsDNA, but doesn't bind histones in contrast to many PHD-type zinc fingers. Sequence=BAC29968.1; Type=Frameshift; Evidence=; Sequence=BAC65842.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter chromosome, centromeric region kinetochore condensed chromosome kinetochore transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding blastocyst hatching DNA binding nucleus nucleoplasm chromosome nucleolus tubulin binding enzyme binding histone binding histone deacetylase binding ribonucleoprotein complex binding sequence-specific DNA binding metal ion binding phosphoprotein binding scaffold protein binding uc009tep.1 uc009tep.2 uc009tep.3 uc009tep.4 
ENSMUST00000078945.12 Grsf1 ENSMUST00000078945.12 G-rich RNA sequence binding factor 1, transcript variant 1 (from RefSeq NM_178700.5) ENSMUST00000078945.1 ENSMUST00000078945.10 ENSMUST00000078945.11 ENSMUST00000078945.2 ENSMUST00000078945.3 ENSMUST00000078945.4 ENSMUST00000078945.5 ENSMUST00000078945.6 ENSMUST00000078945.7 ENSMUST00000078945.8 ENSMUST00000078945.9 GRSF1_MOUSE NM_178700 Q8BR05 Q8BRG7 Q8C5Q4 uc008yac.1 uc008yac.2 uc008yac.3 uc008yac.4 Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G- rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. Involved in the degradosome- mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome. G- quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA. Monomer. Found in a complex with DDX28, DHX30, FASTKD2 and FASTKD5. Interacts with the mitochondrial RNase P complex subunit TRMT10C/MRPP1. Interacts with the 2 components of the mitochondrial degradosome complex, PNPT1 and SUPV3L1, in an RNA-dependent manner. Mitochondrion matrix Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. The RRM domains mediate RNA-binding. positive regulation of mitochondrial RNA catabolic process nucleic acid binding RNA binding cytoplasm mitochondrion RNA processing mRNA processing tRNA processing anterior/posterior pattern specification morphogenesis of embryonic epithelium ribonucleoprotein granule mitochondrial nucleoid uc008yac.1 uc008yac.2 uc008yac.3 uc008yac.4 
ENSMUST00000078952.9 Or1e1c ENSMUST00000078952.9 olfactory receptor family 1 subfamily E member 1C, transcript variant 1 (from RefSeq NM_001172686.1) E9Q4M1 E9Q4M1_MOUSE ENSMUST00000078952.1 ENSMUST00000078952.2 ENSMUST00000078952.3 ENSMUST00000078952.4 ENSMUST00000078952.5 ENSMUST00000078952.6 ENSMUST00000078952.7 ENSMUST00000078952.8 NM_001172686 Olfr376 Or1e1c uc007kao.1 uc007kao.2 uc007kao.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007kao.1 uc007kao.2 uc007kao.3 
ENSMUST00000078953.9 Dennd6b ENSMUST00000078953.9 DENN domain containing 6B (from RefSeq NM_027081.3) B2RSU3 DEN6B_MOUSE ENSMUST00000078953.1 ENSMUST00000078953.2 ENSMUST00000078953.3 ENSMUST00000078953.4 ENSMUST00000078953.5 ENSMUST00000078953.6 ENSMUST00000078953.7 ENSMUST00000078953.8 NM_027081 Q9D9V7 uc029suk.1 uc029suk.2 uc029suk.3 Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35 (By similarity). Recycling endosome Cytoplasm Belongs to the DENND6 family. Identified as having similarity to the core DENN family and referred to as DENN6B. Prediction methods do not indicate a DENN domain for this sequence and, the exact role of the DENN or this DENN-like domain in GEF activity needs to be clarified. Sequence=BAB24583.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; guanyl-nucleotide exchange factor activity cytoplasm endosome Rab guanyl-nucleotide exchange factor activity recycling endosome uc029suk.1 uc029suk.2 uc029suk.3 
ENSMUST00000078961.6 Kifc5b ENSMUST00000078961.6 kinesin family member C5B (from RefSeq NM_053173.2) E9PUA5 E9PUA5_MOUSE ENSMUST00000078961.1 ENSMUST00000078961.2 ENSMUST00000078961.3 ENSMUST00000078961.4 ENSMUST00000078961.5 Kifc5b NM_053173 uc008ber.1 uc008ber.2 uc008ber.3 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding motor activity microtubule motor activity ATP binding nucleus kinesin complex microtubule microtubule-based movement microtubule binding ATPase activity mitotic spindle mitotic spindle assembly uc008ber.1 uc008ber.2 uc008ber.3 
ENSMUST00000078976.9 Zfp706 ENSMUST00000078976.9 zinc finger protein 706 (from RefSeq NM_026521.4) ENSMUST00000078976.1 ENSMUST00000078976.2 ENSMUST00000078976.3 ENSMUST00000078976.4 ENSMUST00000078976.5 ENSMUST00000078976.6 ENSMUST00000078976.7 ENSMUST00000078976.8 NM_026521 Q9D115 ZN706_MOUSE Zfp706 Znf706 uc007vnb.1 uc007vnb.2 Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4. Cytoplasm Nucleus Present in self-renewing embryonic stem cells (ESCs). Does not increase significantly at the onset of differentiation. molecular_function nucleus cytoplasm regulation of translation negative regulation of transcription, DNA-templated metal ion binding negative regulation of stem cell population maintenance uc007vnb.1 uc007vnb.2 
ENSMUST00000079009.11 Tdrd9 ENSMUST00000079009.11 tudor domain containing 9 (from RefSeq NM_029056.1) B1Q3J8 ENSMUST00000079009.1 ENSMUST00000079009.10 ENSMUST00000079009.2 ENSMUST00000079009.3 ENSMUST00000079009.4 ENSMUST00000079009.5 ENSMUST00000079009.6 ENSMUST00000079009.7 ENSMUST00000079009.8 ENSMUST00000079009.9 NM_029056 Q14AW6 Q14BI7 TDRD9_MOUSE Tdrd9 uc011yva.1 uc011yva.2 ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:20059948, PubMed:28633017). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20059948, PubMed:28633017). Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4 (PubMed:28633017). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Interacts with piRNA-associated proteins PIWIL1 and PIWIL4. Cytoplasm cleus Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14BI7-1; Sequence=Displayed; Name=2; IsoId=Q14BI7-2; Sequence=VSP_033554; Name=3; IsoId=Q14BI7-3; Sequence=VSP_033553, VSP_033555; Predominantly expressed in reproductive organs. Detected in mitotic spermatogonia, meiotic spermatocytes (predominantly at the pachytene stage), haploid spermatids in the testis, and in growing oocytes in the ovary (at protein level). Mice are viable but show male sterility with chromosome synapsis failure. In fetal testes, LINE-1 (L1) transposable elements derepression and an aberrant piRNA profile in prospermatogonia, followed by cognate DNA demethylation are observed. Belongs to the DEAD box helicase family. DEAH subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol male meiosis male meiosis I multicellular organism development spermatogenesis fertilization negative regulation of transposition hydrolase activity ATPase activity cell differentiation gene silencing by RNA piRNA metabolic process DNA methylation involved in gamete generation meiotic cell cycle piP-body uc011yva.1 uc011yva.2 
ENSMUST00000079012.13 Marchf8 ENSMUST00000079012.13 membrane associated ring-CH-type finger 8, transcript variant 2 (from RefSeq NM_001302383.2) ENSMUST00000079012.1 ENSMUST00000079012.10 ENSMUST00000079012.11 ENSMUST00000079012.12 ENSMUST00000079012.2 ENSMUST00000079012.3 ENSMUST00000079012.4 ENSMUST00000079012.5 ENSMUST00000079012.6 ENSMUST00000079012.7 ENSMUST00000079012.8 ENSMUST00000079012.9 MARH8_MOUSE March8 Mir NM_001302383 Q9DBD2 uc009djz.1 uc009djz.2 uc009djz.3 uc009djz.4 uc009djz.5 The protein encoded by this gene is a member of the membrane-associated really interesting new gene-CH family of proteins. These proteins are E3 ubiquitin-protein ligases that modulate antigen presentation by downregulating major histocompatibility complex class II surface expression through endocytosis. The transcript is primarily expressed by dendritic cells and macrophages. Overexpression of this gene in antigen presenting cells results in immune defective phenotypes, including resistance to autoimmune disease onset. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity (PubMed:16785530, PubMed:35503863). Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins. Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation. Mediates the regulation of constitutive ubiquitination and trafficking of the viral restriction factor BST2 within the endocytic pathway. Plays a role in maintenance of immune tolerance to self by promoting the turnover and proteasomal degradation of PD-L1/CD274 via ubiquitination. Catalyzes the 'Lys-63'-linked polyubiquitylation of cGAS thereby inhibiting its DNA binding ability and impairing its antiviral innate immunity (PubMed:35503863). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with CD86. Golgi apparatus membrane Endoplasmic reticulum membrane Cytoplasmic vesicle membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Early endosome membrane ; Multi-pass membrane protein The RING-CH-type zinc finger domain is required for E3 ligase activity. March8-deficient mice are less susceptible than WT mice to herpesvirus infection. protein polyubiquitination adaptive immune response immune system process antigen processing and presentation of peptide antigen via MHC class II ubiquitin-protein transferase activity lysosome lysosomal membrane endosome zinc ion binding membrane integral component of membrane protein ubiquitination transferase activity cytoplasmic vesicle membrane cytoplasmic vesicle early endosome membrane MHC class II protein binding negative regulation of MHC class II biosynthetic process metal ion binding ubiquitin protein ligase activity uc009djz.1 uc009djz.2 uc009djz.3 uc009djz.4 uc009djz.5 
ENSMUST00000079020.12 Slc24a4 ENSMUST00000079020.12 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4, transcript variant 1 (from RefSeq NM_172152.4) ENSMUST00000079020.1 ENSMUST00000079020.10 ENSMUST00000079020.11 ENSMUST00000079020.2 ENSMUST00000079020.3 ENSMUST00000079020.4 ENSMUST00000079020.5 ENSMUST00000079020.6 ENSMUST00000079020.7 ENSMUST00000079020.8 ENSMUST00000079020.9 NCKX4_MOUSE NM_172152 Nckx4 Q8BLL5 Q8BLL7 Q8CGQ8 Slc24a4 uc288itj.1 uc288itj.2 Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:22057188). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived (PubMed:22057188). May play a role in calcium transport during amelogenesis (PubMed:23375655). Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29108; Evidence=; Cell membrane ulti-pass membrane protein Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CGQ8-1; Sequence=Displayed; Name=2; IsoId=Q8CGQ8-2; Sequence=VSP_041610, VSP_041611; Expressed in late secretory-stage and maturation- stage ameloblasts, with significantly increased expression during the late stages of amelogenesis (at protein level) (PubMed:22677781, PubMed:24621671, PubMed:26247047). Widely expressed in most regions of the brain, including hippocampus, neocortex, thalamus, striatum and olfactory bulb (PubMed:12379639). Expressed in the olfactory sensory neurons (PubMed:22057188). Mice have a reduced ability to locate an odorous source and lower body weights. The olfactory sensory neurons display defects in response termination and adaptation but have unchanged sensitivity (PubMed:22057188). Mice show severe enamel defects (PubMed:23375655). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. It is uncertain whether Met-1 or Met-18 is the initiator. Sequence=AAN37415.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC31835.1; Type=Frameshift; Evidence=; Sequence=BAC31835.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; calcium channel activity calcium:sodium antiporter activity cytoplasm plasma membrane integral component of plasma membrane ion transport potassium ion transport sodium ion transport calcium ion transport cellular calcium ion homeostasis sensory perception of smell calcium, potassium:sodium antiporter activity symporter activity antiporter activity membrane integral component of membrane sodium ion transmembrane transport response to stimulus transmembrane transport calcium ion transmembrane transport potassium ion transmembrane transport amelogenesis anion transmembrane transport uc288itj.1 uc288itj.2 
ENSMUST00000079028.6 Pop1 ENSMUST00000079028.6 processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae), transcript variant 2 (from RefSeq NM_026340.3) ENSMUST00000079028.1 ENSMUST00000079028.2 ENSMUST00000079028.3 ENSMUST00000079028.4 ENSMUST00000079028.5 NM_026340 Pop1 Q9D4G5 Q9D4G5_MOUSE uc007vlv.1 uc007vlv.2 uc007vlv.3 uc007vlv.4 ribonuclease MRP activity ribonuclease MRP complex tRNA 5'-leader removal ribonuclease P activity nucleolar ribonuclease P complex nucleolus tRNA processing tRNA catabolic process multimeric ribonuclease P complex ribonuclease P RNA binding RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc007vlv.1 uc007vlv.2 uc007vlv.3 uc007vlv.4 
ENSMUST00000079033.6 Bloc1s2 ENSMUST00000079033.6 biogenesis of lysosomal organelles complex-1, subunit 2 (from RefSeq NM_028607.1) A2ATZ7 BL1S2_MOUSE Blos2 ENSMUST00000079033.1 ENSMUST00000079033.2 ENSMUST00000079033.3 ENSMUST00000079033.4 ENSMUST00000079033.5 NM_028607 Q6P062 Q9CWG9 uc008hpl.1 uc008hpl.2 uc008hpl.3 uc008hpl.4 uc008hpl.5 uc008hpl.6 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (By similarity). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:16760431, PubMed:21998198). The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:19546860). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity). Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Interacts directly with BLOC1S1, BLOC1S3, BLOC1S4, BLOC1S5 and SNAPIN (PubMed:15102850). The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos (PubMed:21998198). Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (By similarity). Interacts with gamma-tubulin (By similarity). Interacts with IFT57 (PubMed:18188704). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Lysosome membrane Note=Localizes to the centrosomes in a microtubule-dependent manner. Belongs to the BLOC1S2 family. Sequence=AAH65806.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; gamma-tubulin complex nucleus cytoplasm mitochondrion lysosome lysosomal membrane centrosome microtubule organizing center cytosol cytoskeleton protein C-terminus binding anterograde axonal transport positive regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors membrane endosomal transport BLOC-1 complex neuron projection development lysosome localization gamma-tubulin binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter anterograde synaptic vesicle transport recycling endosome mitochondrial outer membrane permeabilization BORC complex axon cytoplasm uc008hpl.1 uc008hpl.2 uc008hpl.3 uc008hpl.4 uc008hpl.5 uc008hpl.6 
ENSMUST00000079035.3 Tas2r113 ENSMUST00000079035.3 taste receptor, type 2, member 113 (from RefSeq NM_207018.1) ENSMUST00000079035.1 ENSMUST00000079035.2 NM_207018 Q7M711 T2r58 TR113_MOUSE Tas2r113 uc009ejt.1 uc009ejt.2 Putative taste receptor which may play a role in the perception of bitterness. Membrane ; Multi-pass membrane protein Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009ejt.1 uc009ejt.2 
ENSMUST00000079038.4 Hhip ENSMUST00000079038.4 Hedgehog-interacting protein, transcript variant 1 (from RefSeq NM_020259.4) ENSMUST00000079038.1 ENSMUST00000079038.2 ENSMUST00000079038.3 HHIP_MOUSE Hip NM_020259 Q7TN16 Q8C0B0 Q9WU59 uc009mix.1 uc009mix.2 uc009mix.3 uc009mix.4 Modulates hedgehog signaling in several cell types, including brain and lung through direct interaction with members of the hedgehog family. Soluble forms inhibit Shh-induced differentiation in the fibroblast cell line C3H/10T1/2. Interacts with all three hedgehog family members, SHH, IHH and DHH. Cell membrane ; Peripheral membrane protein Secreted Note=The last 22 C-terminal amino acids may participate in cell membrane attachment. In the adult brain, high expression found in the ventral cochlear nucleus, medial habenula, indusium griseum and tenia tecta. Some expression also in the caudate putamen, the nucleus accumbens, the ventral pallidum and in the superficial layers of the superior colliculus. First detected at 8.75 dpc, in the ventral midline of the neural tube and in the ventral medial somites. At 10.5 dpc, expression in the notochord is maintained in the caudal region. Expression is lost in the floor plate, but is retained in the ventral half of the neural tube and in the sclerotome of the adjacent somites. In the midbrain, expression confined to two lateral stripes adjacent to the floor plate. Also expressed in the gut mesenchyme along the length of the gastro-intestinal tract and in the mesenchyme of the posterior half of the limb. Expressed in the underlying mesenchyme of the epithelium of a number of tissues including lung, gut and whisker. Also expressed in the perichondrium and in the androgen-producing interstitial somatic cells of the developing testis. A flexible loop interacts with the SHH zinc binding site and contributes to zinc binding. Belongs to the HHIP family. catalytic activity protein binding extracellular region nucleus cytoplasm plasma membrane integral component of plasma membrane signal transduction neuroblast proliferation zinc ion binding animal organ morphogenesis dorsal/ventral pattern formation negative regulation of signal transduction cell surface membrane negative regulation of angiogenesis regulation of fibroblast growth factor receptor signaling pathway negative regulation of apoptotic process negative regulation of smoothened signaling pathway metal ion binding skeletal system morphogenesis epithelial tube branching involved in lung morphogenesis hedgehog family protein binding uc009mix.1 uc009mix.2 uc009mix.3 uc009mix.4 
ENSMUST00000079041.7 Slc35e3 ENSMUST00000079041.7 solute carrier family 35, member E3 (from RefSeq NM_029875.2) ENSMUST00000079041.1 ENSMUST00000079041.2 ENSMUST00000079041.3 ENSMUST00000079041.4 ENSMUST00000079041.5 ENSMUST00000079041.6 NM_029875 Q6PGC7 S35E3_MOUSE uc007hdn.1 uc007hdn.2 uc007hdn.3 Putative transporter. Membrane ; Multi-pass membrane protein Belongs to the TPT transporter family. SLC35E subfamily. nucleotide-sugar transmembrane transporter activity Golgi apparatus antiporter activity nucleobase-containing compound transport membrane integral component of membrane transmembrane transporter activity transmembrane transport carbohydrate derivative transport uc007hdn.1 uc007hdn.2 uc007hdn.3 
ENSMUST00000079063.7 Sox11 ENSMUST00000079063.7 SRY (sex determining region Y)-box 11 (from RefSeq NM_009234.6) ENSMUST00000079063.1 ENSMUST00000079063.2 ENSMUST00000079063.3 ENSMUST00000079063.4 ENSMUST00000079063.5 ENSMUST00000079063.6 NM_009234 O35178 O89036 Q04889 Q7M6Y2 Q80XF0 SOX11_MOUSE Sox-11 uc007nfn.1 uc007nfn.2 uc007nfn.3 uc007nfn.4 Transcription factor that acts as a transcriptional activator (PubMed:18505825, PubMed:18403418). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (PubMed:18505825, PubMed:18403418). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (PubMed:20596238). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (PubMed:20596238). Nucleus Expression prominent in the periventricular cells of the central nervous system, also observed in a wide range of tissues involved in epithelial-mesenchymal interactions. Expression detected from 8.5 dpc through to 13.5 dpc, with a considerable increase in expression apparent at 13.5 dpc (PubMed:9337129, PubMed:18505825, PubMed:20596238). Expressed throughout the central and peripheral nervous system, as well as the mesenchyme of many developing organs between 12.5 dpc and 14.5 dpc (PubMed:18403418). Abundantly expressed in the developing cerebral cortex, thalamus, hippocampus, cerebellar cortex, and ganglia in the brain at 14.5 dpc and 16.5 dpc with low expression at 18.5 dpc (PubMed:18505825). Abundantly expressed in the gut epithelium at 14.5 dpc (PubMed:18505825). Abundantly expressed in the olfactory epithelium with low expression in skin, spinal cord, kidney, heart, muscle, cartilage from 14.5 dpc to 18.5 dpc (PubMed:18505825). Very low expression in intestine and lung, with no expression detectable at 18.5 dpc (PubMed:18505825). Abundantly expressed in the subventricular zone of the brain at 18.5 dpc (PubMed:18505825). Expressed in the brain at postnatal day 2 (PubMed:18403418). Mice die at birth with numerous morphological abnormalities (PubMed:20596238). Incomplete separation of the heart ventricles with fused aorta and pulmonary arteries (PubMed:20596238). Skeletal malformations including hypoplastic sternebrae, unfused vertebral bodies and hypomineralized skull (PubMed:20596238). All mice have microphthalmia and open eyelids, with 50% of mice exhibiting omphalocele, and 40% exhibiting cleft palate, cleft lips and a tail kink (PubMed:20596238). Sox11 and Sox4 double knockout mice die in utero at 10.5 dpc (PubMed:20596238). Embryos are small and unturned with developmental defects such as failure of heart primordia fusion, a thin and undulated neural tube, failure of limb budding and somite formation, suggesting developmental arrest at 8.5 dpc (PubMed:20596238). Embryos showed reduced cell proliferation and increased cell death in the neural tube, branchial arches, somites and reduced expression of Tead2 at 9.5 dpc (PubMed:20596238). Sox4, Sox11, and Sox12 triple knockout mice show severe thinning and undulation of the neural tube (PubMed:20596238). negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development kidney development neural tube formation lens morphogenesis in camera-type eye outflow tract morphogenesis cardiac ventricle formation noradrenergic neuron differentiation DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity nucleus cytoplasm regulation of transcription, DNA-templated multicellular organism development nervous system development cell proliferation positive regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression oligodendrocyte development glial cell proliferation neural crest cell development regulation of transforming growth factor beta receptor signaling pathway spinal cord development glial cell development cell differentiation neuron differentiation positive regulation of BMP signaling pathway positive regulation of hippo signaling skeletal muscle cell differentiation nuclear transcription factor complex positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of ossification positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of hormone secretion sympathetic nervous system development embryonic digestive tract morphogenesis embryonic skeletal system morphogenesis negative regulation of lymphocyte proliferation positive regulation of neurogenesis hard palate development soft palate development limb bud formation negative regulation of glial cell proliferation ventricular septum morphogenesis lung morphogenesis negative regulation of cell death neuroepithelial cell differentiation eyelid development in camera-type eye somite development cornea development in camera-type eye closure of optic fissure signal transduction involved in cell cycle checkpoint positive regulation of stem cell proliferation negative regulation of transcription regulatory region DNA binding positive regulation of lens epithelial cell proliferation uc007nfn.1 uc007nfn.2 uc007nfn.3 uc007nfn.4 
ENSMUST00000079080.13 Mapk7 ENSMUST00000079080.13 mitogen-activated protein kinase 7, transcript variant 1 (from RefSeq NM_011841.2) Bmk1 ENSMUST00000079080.1 ENSMUST00000079080.10 ENSMUST00000079080.11 ENSMUST00000079080.12 ENSMUST00000079080.2 ENSMUST00000079080.3 ENSMUST00000079080.4 ENSMUST00000079080.5 ENSMUST00000079080.6 ENSMUST00000079080.7 ENSMUST00000079080.8 ENSMUST00000079080.9 Erk5 MK07_MOUSE NM_011841 Q3U2N7 Q3UG52 Q497T0 Q5NCN6 Q5NCN7 Q5NCN9 Q6QLU8 Q9R1D9 Q9WVF3 Q9WVF4 Q9WVS8 uc007jhq.1 uc007jhq.2 uc007jhq.3 uc007jhq.4 Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by tyrosine and threonine phosphorylation. Activated in response to hyperosmolarity, hydrogen peroxide, and epidermal growth factor (EGF) (By similarity). Interacts with MAP2K5 (By similarity). Forms oligomers. Interacts with MEF2A, MEF2C and MEF2D; the interaction phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D (By similarity). Interacts with SGK1 (By similarity). Interacts with PML (By similarity). Interacts (via N-terminal half) with HSP90AB1-CDC37 chaperone complex in resting cells; the interaction is MAP2K5-independent and prevents MAPK7 from ubiquitination and proteasomal degradation (PubMed:23428871). Cytoplasm Nucleus Nucleus, PML body Note=Translocates to the nucleus upon activation. [Isoform 1]: Cytoplasm Nucleus Note=Isoform 1 is detected in cytoplasm and nucleus. [Isoform 2]: Nucleus Note=Isoform 2 is detected only in the nucleus. Translocates to the nucleus upon activation (By similarity). [Isoform 3]: Nucleus Note=Isoform 2 is detected only in the nucleus. Translocates to the nucleus upon activation (By similarity). Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Big MAP kinase 1a, mERK5a; IsoId=Q9WVS8-1; Sequence=Displayed; Name=2; Synonyms=Big MAP kinase 1b, mERK5b; IsoId=Q9WVS8-2; Sequence=VSP_035202; Name=3; Synonyms=Big MAP kinase 1c, mERK5c; IsoId=Q9WVS8-3; Sequence=VSP_035201; Name=4; Synonyms=Big MAP kinase 1d, mERK5-T; IsoId=Q9WVS8-4; Sequence=VSP_035203; Name=5; IsoId=Q9WVS8-5; Sequence=VSP_035204; Detected in testis, brain, kidney, lung and heart. Detected in total embryo (at protein level). The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme. [Isoform 2]: May not have a kinase activity. May not stimulate MEF2C activity. May function as dominant negative inhibitor of the ERK5 signaling pathway. [Isoform 3]: May not have a kinase activity. May not stimulate MEF2C activity. May function as dominant negative inhibitor of the ERK5 signaling pathway. [Isoform 4]: Unable to translocate from the cytoplasm to the nucleus. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. MAPK cascade nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol protein phosphorylation cell cycle regulation of gene expression kinase activity phosphorylation PML body transferase activity peptidyl-serine phosphorylation cell differentiation negative regulation of heterotypic cell-cell adhesion intracellular signal transduction positive regulation of transcription from RNA polymerase II promoter in response to stress negative regulation of apoptotic process negative regulation of MAP kinase activity regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter mitogen-activated protein kinase binding positive regulation of protein metabolic process negative regulation of response to cytokine stimulus cellular response to hydrogen peroxide negative regulation of ERK5 cascade negative regulation of calcineurin-NFAT signaling cascade cellular response to growth factor stimulus cellular response to laminar fluid shear stress cellular response to transforming growth factor beta stimulus negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc007jhq.1 uc007jhq.2 uc007jhq.3 uc007jhq.4 
ENSMUST00000079081.8 Aqp4 ENSMUST00000079081.8 aquaporin 4, transcript variant 1 (from RefSeq NM_009700.3) A0A0R4J0Z3 A0A0R4J0Z3_MOUSE Aqp4 ENSMUST00000079081.1 ENSMUST00000079081.2 ENSMUST00000079081.3 ENSMUST00000079081.4 ENSMUST00000079081.5 ENSMUST00000079081.6 ENSMUST00000079081.7 NM_009700 uc008eds.1 uc008eds.2 uc008eds.3 uc008eds.4 uc008eds.5 This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]. Cell membrane, sarcolemma ; Multi-pass membrane protein Cell projection Endosome membrane Membrane ; Multi-pass membrane protein Belongs to the MIP/aquaporin (TC 1.A.8) family. cytoplasm plasma membrane integral component of plasma membrane water transport external side of plasma membrane water channel activity channel activity porin activity membrane integral component of membrane sarcolemma pore complex multicellular organismal water homeostasis protein homotetramerization transmembrane transport cellular response to interferon-gamma uc008eds.1 uc008eds.2 uc008eds.3 uc008eds.4 uc008eds.5 
ENSMUST00000079083.12 Pear1 ENSMUST00000079083.12 platelet endothelial aggregation receptor 1, transcript variant 5 (from RefSeq NM_001289600.1) ENSMUST00000079083.1 ENSMUST00000079083.10 ENSMUST00000079083.11 ENSMUST00000079083.2 ENSMUST00000079083.3 ENSMUST00000079083.4 ENSMUST00000079083.5 ENSMUST00000079083.6 ENSMUST00000079083.7 ENSMUST00000079083.8 ENSMUST00000079083.9 Jedi Megf12 NM_001289600 PEAR1_MOUSE Q3URX7 Q6KAQ6 Q8CGA7 Q8VHF4 Q8VHL7 Q8VIK5 uc008pst.1 uc008pst.2 Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (PubMed:17226770). Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation (By similarity). Interacts (via extracellular domain) with SVEP1 (By similarity). Cell membrane ; Single-pass membrane protein Cell projection, lamellipodium Note=Detected on the cell surface in resting platelets. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8VIK5-1; Sequence=Displayed; Name=2; IsoId=Q8VIK5-2; Sequence=VSP_029261; Name=3; Synonyms=Jedi-736; IsoId=Q8VIK5-3; Sequence=VSP_029262, VSP_029263; Name=4; IsoId=Q8VIK5-4; Sequence=VSP_029260; Expressed in thymocytes, bone marrow stromal and osteogenic cells (at protein level) (PubMed:17226770). Strongly expressed in kidney and heart (PubMed:17226770). Moderately expressed in lung, spleen, thymus, liver, brain, testis, skin and stomach (PubMed:17226770). Expressed in hematopoietic stem progenitor cells (PubMed:17226770). Expressed in the heart and lung at 16 dpc. Phosphorylated in the intracellular domain on tyrosine residues (PubMed:17226770). Phosphorylated on tyrosine residues by SRC (By similarity). Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet- platelet contacts but not after platelet activation (By similarity). Tyrosine phosphorylation enhanced its association with SHC1 and SHC2 (By similarity). Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated when in the presence of SVEP1 (By similarity). Belongs to the MEGF family. Sequence=BAE24560.1; Type=Erroneous initiation; Evidence=; phagocytic cup plasma membrane phosphatidylinositol 3-kinase signaling membrane integral component of membrane signaling receptor activity protein kinase B signaling recognition of apoptotic cell negative regulation of Notch signaling pathway platelet aggregation uc008pst.1 uc008pst.2 
ENSMUST00000079085.11 Rpl34 ENSMUST00000079085.11 ribosomal protein L34, transcript variant 2 (from RefSeq NM_001005859.3) ENSMUST00000079085.1 ENSMUST00000079085.10 ENSMUST00000079085.2 ENSMUST00000079085.3 ENSMUST00000079085.4 ENSMUST00000079085.5 ENSMUST00000079085.6 ENSMUST00000079085.7 ENSMUST00000079085.8 ENSMUST00000079085.9 NM_001005859 Q497V4 Q9D1R9 RL34_MOUSE uc008rje.1 uc008rje.2 uc008rje.3 uc008rje.4 uc008rje.5 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Cytoplasm, cytosol Cytoplasm Endoplasmic reticulum Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). Belongs to the eukaryotic ribosomal protein eL34 family. structural constituent of ribosome cytoplasm mitochondrion endoplasmic reticulum cytosol ribosome translation cytosolic large ribosomal subunit uc008rje.1 uc008rje.2 uc008rje.3 uc008rje.4 uc008rje.5 
ENSMUST00000079099.2 Vmn1r240 ENSMUST00000079099.2 vomeronasal 1 receptor 240 (from RefSeq NM_001167148.1) D3YZG3 D3YZG3_MOUSE ENSMUST00000079099.1 Gm16442 Gm16451 NM_001167148 Vmn1r240 uc012fbp.1 uc012fbp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fbp.1 uc012fbp.2 
ENSMUST00000079121.4 Mrpl18 ENSMUST00000079121.4 mitochondrial ribosomal protein L18 (from RefSeq NM_026310.3) ENSMUST00000079121.1 ENSMUST00000079121.2 ENSMUST00000079121.3 NM_026310 Q9CQL5 Q9D6N7 RM18_MOUSE uc008alj.1 uc008alj.2 uc008alj.3 Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity). Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uL18 family. RNA binding structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation 5S rRNA binding rRNA import into mitochondrion uc008alj.1 uc008alj.2 uc008alj.3 
ENSMUST00000079125.8 Scand1 ENSMUST00000079125.8 SCAN domain-containing 1 (from RefSeq NM_020255.3) ENSMUST00000079125.1 ENSMUST00000079125.2 ENSMUST00000079125.3 ENSMUST00000079125.4 ENSMUST00000079125.5 ENSMUST00000079125.6 ENSMUST00000079125.7 NM_020255 Q2M4I6 Q2M4I6_MOUSE Scand1 uc008nnc.1 uc008nnc.2 uc008nnc.3 uc008nnc.4 uc008nnc.5 May regulate transcriptional activity. Interacts with ZNF202. Nucleus transcription factor activity, sequence-specific DNA binding transcription coactivator activity nucleus regulation of transcription, DNA-templated positive regulation of nucleic acid-templated transcription uc008nnc.1 uc008nnc.2 uc008nnc.3 uc008nnc.4 uc008nnc.5 
ENSMUST00000079132.12 Chia1 ENSMUST00000079132.12 chitinase, acidic 1 (from RefSeq NM_023186.3) A0T468 B8K282 CHIA_MOUSE Chia ENSMUST00000079132.1 ENSMUST00000079132.10 ENSMUST00000079132.11 ENSMUST00000079132.2 ENSMUST00000079132.3 ENSMUST00000079132.4 ENSMUST00000079132.5 ENSMUST00000079132.6 ENSMUST00000079132.7 ENSMUST00000079132.8 ENSMUST00000079132.9 NM_023186 Q3TVE7 Q91XA9 Q99PH2 Q9D803 Q9JLN1 uc008qvv.1 uc008qvv.2 uc008qvv.3 uc008qvv.4 Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Presence in saliva and gastric juice suggests a function as a digestive enzyme. Reaction=Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.; EC=3.2.1.14; Evidence=; pH dependence: Optimum pH is below 2.5. ; Interacts with EGFR. Secreted. Cytoplasm. Cytoplasmic granule. Note=Detected in secretory granules of parotid acinar cells and gastric chief cells and secreted from them into saliva and gastric juice, respectively. Detected in macrophages and lung epithelial cells. Detected in the acinar cells of parotid gland and von Ebner's gland but not in submandibular and sublingual glands. Detected in gastric chief cells. Also present in parotid glandular saliva and gastric juice (at protein level). Highly expressed in submandibular gland (PubMed:11085997) and stomach. Highly expressed in parotid gland but not in submandibular and sublingual glands (PubMed:12133911). In tongue, expressed only in von Ebner's gland. Expressed at lower levels in lung. In parotid gland, weak expression detected at postnatal day P12, with levels increasing towards P16. In stomach, first detected at P16, with expression reaching adult levels during P20-24. Up-regulated upon pulmonary inflammation elicited by sensitization and aerosol challenge with the aeroallergen ovalbumin. Up-regulated during T-helper cell type 2 (Th2) inflammation. Induction is mediated by IL-13. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. Sequence=AAH11134.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; polysaccharide catabolic process response to yeast immune system process production of molecular mediator involved in inflammatory response hydrolase activity, hydrolyzing O-glycosyl compounds chitinase activity extracellular region extracellular space cytoplasm carbohydrate metabolic process chitin metabolic process chitin catabolic process apoptotic process inflammatory response immune response chitin binding metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds kinase binding catabolism by host of symbiont cell wall chitin positive regulation of chemokine secretion uc008qvv.1 uc008qvv.2 uc008qvv.3 uc008qvv.4 
ENSMUST00000079134.5 Taar2 ENSMUST00000079134.5 trace amine-associated receptor 2 (from RefSeq NM_001007266.1) A6H6B2 ENSMUST00000079134.1 ENSMUST00000079134.2 ENSMUST00000079134.3 ENSMUST00000079134.4 Gm225 Gpr58 NM_001007266 Q5QD17 Q80T53 TAAR2_MOUSE uc007eqe.1 uc007eqe.2 Orphan olfactory receptor specific for trace amines. Cell membrane ; Multi-pass membrane protein Specifically expressed in neurons of the olfactory epithelium. Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2- phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled amine receptor activity membrane integral component of membrane uc007eqe.1 uc007eqe.2 
ENSMUST00000079158.13 Abcc5 ENSMUST00000079158.13 ATP-binding cassette, sub-family C member 5, transcript variant 1 (from RefSeq NM_013790.2) Abcc5 Abcc5a ENSMUST00000079158.1 ENSMUST00000079158.10 ENSMUST00000079158.11 ENSMUST00000079158.12 ENSMUST00000079158.2 ENSMUST00000079158.3 ENSMUST00000079158.4 ENSMUST00000079158.5 ENSMUST00000079158.6 ENSMUST00000079158.7 ENSMUST00000079158.8 ENSMUST00000079158.9 MRP5_MOUSE Mrp5 NM_013790 O88284 Q5CZY2 Q9R1X5 uc007ypp.1 uc007ypp.2 uc007ypp.3 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites like cyclic nucleotides, such as cAMP and cGMP, folic acid and N- lactoyl-amino acids (in vitro) (By similarity) (PubMed:17229149). Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins (PubMed:26515061). Confers resistance to the antiviral agent PMEA (By similarity). Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity (By similarity). Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (PubMed:31338999). Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.; EC=7.6.2.2; Evidence=; Reaction=3',5'-cyclic GMP(in) + ATP + H2O = 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:66188, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57746, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66189; Evidence=; Reaction=3',5'-cyclic AMP(in) + ATP + H2O = 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:66184, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58165, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66185; Evidence=; Reaction=ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate; Xref=Rhea:RHEA:66728, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:76931, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66729; Evidence=; Reaction=ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate; Xref=Rhea:RHEA:66732, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:76935, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66733; Evidence=; Reaction=ATP + H2O + N-acetyl-L-glutamate(in) = ADP + H(+) + N-acetyl- L-glutamate(out) + phosphate; Xref=Rhea:RHEA:66740, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:44337, ChEBI:CHEBI:456216; Evidence=; Reaction=ATP + H2O + N-acetyl-L-aspartate(in) = ADP + H(+) + N-acetyl- L-aspartate(out) + phosphate; Xref=Rhea:RHEA:66744, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16953, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66745; Evidence=; Reaction=(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4- carboxamido]succinate(in) + ATP + H2O = (2S)-2-[5-amino-1-(beta-D- ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:66752, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:167466, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66753; Evidence=; Reaction=ATP + domoate(in) + H2O = ADP + domoate(out) + H(+) + phosphate; Xref=Rhea:RHEA:66756, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:167470, ChEBI:CHEBI:456216; Evidence=; Reaction=ATP + beta-citrylglutamate(in) + H2O = ADP + beta- citrylglutamate(out) + H(+) + phosphate; Xref=Rhea:RHEA:66736, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:76942, ChEBI:CHEBI:456216; Evidence=; Reaction=ATP + H2O + kainate(in) = ADP + H(+) + kainate(out) + phosphate; Xref=Rhea:RHEA:66760, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:156548, ChEBI:CHEBI:456216; Evidence=; Reaction=ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) = ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate; Xref=Rhea:RHEA:66720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:167456, ChEBI:CHEBI:456216; Evidence=; Reaction=ATP + folate(in) + H2O = ADP + folate(out) + H(+) + phosphate; Xref=Rhea:RHEA:66764, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:62501, ChEBI:CHEBI:456216; Evidence=; Kinetic parameters: KM=9 mM for cGMP ; Basolateral cell membrane ; Multi-pass membrane protein Golgi apparatus lumen Endosome membrane Cytoplasmic granule Apical cell membrane ; Multi-pass membrane protein Note=In most cells, routes to the basolateral plasma membrane, but in the brain capillary endothelial cells that form the blood-brain barrier, resides in the apical membrane. Detected in brain endothelial cells. Mrp5 knockout mice are viable with no overt phenotypes, deficient mice accumulate endogenous glutamate conjugates in several tissues, including the inhibitory neuropeptides N- acetylaspartylglutamate (NAAG) and N-acetylaspartyldiglutamate (NAAG2), but brain in particular (PubMed:26515061). Abcc5-/- mice show lower white and brown adipose tissue and increased glucagon-like peptide 1 (GLP-1) release from enteroendocrine cells of the small intestine, and are more insulin sensitive (PubMed:31338999). Although other labs have confirmed the ability of ABCC5 to transport cGMP in an ATP-dependent manner, they obtained a much lower affinity for this substrate (By similarity) (PubMed:17229149). The authors conclude that ABCC5 is a low-affinity cyclic nucleotide transporter and a major function in cGMP excretion is unlikely (By similarity) (PubMed:17229149). Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. nucleotide binding ATP binding organic anion transmembrane transporter activity organic anion transport membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances perinuclear region of cytoplasm transmembrane transport uc007ypp.1 uc007ypp.2 uc007ypp.3 
ENSMUST00000079160.8 Letm2 ENSMUST00000079160.8 leucine zipper-EF-hand containing transmembrane protein 2, transcript variant 5 (from RefSeq NR_157064.1) ENSMUST00000079160.1 ENSMUST00000079160.2 ENSMUST00000079160.3 ENSMUST00000079160.4 ENSMUST00000079160.5 ENSMUST00000079160.6 ENSMUST00000079160.7 LETM2_MOUSE NR_157064 Q7TNU7 uc009lgf.1 uc009lgf.2 uc009lgf.3 uc009lgf.4 Mitochondrion inner membrane ; Single-pass membrane protein Despite its name, it does not contain any EF-hand domains. molecular_function mitochondrion mitochondrial inner membrane membrane integral component of membrane ribosome binding uc009lgf.1 uc009lgf.2 uc009lgf.3 uc009lgf.4 
ENSMUST00000079163.5 Vmn2r10 ENSMUST00000079163.5 vomeronasal 2, receptor 10, transcript variant 1 (from RefSeq NM_009491.4) ENSMUST00000079163.1 ENSMUST00000079163.2 ENSMUST00000079163.3 ENSMUST00000079163.4 K7N621 K7N621_MOUSE NM_009491 Vmn2r10 uc009vdh.1 uc009vdh.2 uc009vdh.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vdh.1 uc009vdh.2 uc009vdh.3 
ENSMUST00000079184.6 Stfa2l1 ENSMUST00000079184.6 stefin A2 like 1 (from RefSeq NM_173869.3) ENSMUST00000079184.1 ENSMUST00000079184.2 ENSMUST00000079184.3 ENSMUST00000079184.4 ENSMUST00000079184.5 NM_173869 Q8BWM3 Q8BWM3_MOUSE Stfa2l1 uc007zcg.1 uc007zcg.2 uc007zcg.3 Belongs to the cystatin family. endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity cytosol biological_process negative regulation of endopeptidase activity uc007zcg.1 uc007zcg.2 uc007zcg.3 
ENSMUST00000079186.3 Gm839 ENSMUST00000079186.3 predicted gene 839 (from RefSeq NR_033190.1) ENSMUST00000079186.1 ENSMUST00000079186.2 NR_033190 uc009cwe.1 uc009cwe.2 uc009cwe.3 uc009cwe.4 uc009cwe.1 uc009cwe.2 uc009cwe.3 uc009cwe.4 
ENSMUST00000079195.6 Stox2 ENSMUST00000079195.6 storkhead box 2, transcript variant 4 (from RefSeq NM_001363119.1) B2RR59 ENSMUST00000079195.1 ENSMUST00000079195.2 ENSMUST00000079195.3 ENSMUST00000079195.4 ENSMUST00000079195.5 Kiaa1392 NM_001363119 Q3TRF0 Q497F9 Q499E5 Q6ZPS3 Q8CDI1 STOX2_MOUSE uc009lqx.1 uc009lqx.2 uc009lqx.3 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q499E5-1; Sequence=Displayed; Name=2; IsoId=Q499E5-2; Sequence=VSP_030075, VSP_030076; Name=3; IsoId=Q499E5-3; Sequence=VSP_030074, VSP_030075, VSP_030076; Sequence=BAC98156.1; Type=Erroneous initiation; Evidence=; maternal placenta development molecular_function cellular_component regulation of transcription from RNA polymerase II promoter response to bacterium embryo development ending in birth or egg hatching uc009lqx.1 uc009lqx.2 uc009lqx.3 
ENSMUST00000079205.14 Chpf ENSMUST00000079205.14 chondroitin polymerizing factor, transcript variant 1 (from RefSeq NM_001001566.3) CHSS2_MOUSE Chpf Css2 D1Bwg1363e E9PUB9 ENSMUST00000079205.1 ENSMUST00000079205.10 ENSMUST00000079205.11 ENSMUST00000079205.12 ENSMUST00000079205.13 ENSMUST00000079205.2 ENSMUST00000079205.3 ENSMUST00000079205.4 ENSMUST00000079205.5 ENSMUST00000079205.6 ENSMUST00000079205.7 ENSMUST00000079205.8 ENSMUST00000079205.9 NM_001001566 Q6IQX7 uc007bpj.1 uc007bpj.2 uc007bpj.3 uc007bpj.4 Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer. Seems to act as a specific activating factor for CHSY1 in chondroitin polymerization. [Isoform 2]: May facilitate PRKN transport into the mitochondria. In collaboration with PRKN, may enhance cell viability and protect cells from oxidative stress. Reaction=3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA- (1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl- [protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc- (1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)- beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:20800, Rhea:RHEA-COMP:14058, Rhea:RHEA- COMP:14059, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:138442, ChEBI:CHEBI:138443; EC=2.4.1.175; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20801; Evidence=; Reaction=3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA- (1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)- beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha- D-galactosamine = 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA- (1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal- (1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:55000, Rhea:RHEA-COMP:14060, Rhea:RHEA-COMP:14301, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:138444, ChEBI:CHEBI:138445; EC=2.4.1.175; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55001; Evidence=; Reaction=3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal- (1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D- glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl- [protein] + H(+) + UDP; Xref=Rhea:RHEA:23428, Rhea:RHEA-COMP:12575, Rhea:RHEA-COMP:14058, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132105, ChEBI:CHEBI:138442; EC=2.4.1.226; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23429; Evidence=; Reaction=3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D- GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)- beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta- D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D- GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)- beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:54996, Rhea:RHEA-COMP:14060, Rhea:RHEA-COMP:14061, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:138444, ChEBI:CHEBI:138445; EC=2.4.1.226; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54997; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Note=Highest activities are measured with Mn(2+). Can also utilize Co(2+). ; [Isoform 1]: Interacts with PRKN. [Isoform 2]: Interacts with PRKN. [Isoform 3]: Interacts with PRKN. Q6IQX7-2; Q9WVS6: Prkn; NbExp=3; IntAct=EBI-9029659, EBI-973635; [Isoform 1]: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Cytoplasm, cytosol [Isoform 3]: Cytoplasm, cytosol Mitochondrion [Isoform 2]: Mitochondrion matrix Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6IQX7-1; Sequence=Displayed; Name=2; Synonyms=Klokin1; IsoId=Q6IQX7-2; Sequence=VSP_053435; Name=3; Synonyms=ChPF(D996); IsoId=Q6IQX7-3; Sequence=VSP_053436; Isoform 1, isoform 2 and isoform 3 are expressed in brain (at protein level). Belongs to the chondroitin N- acetylgalactosaminyltransferase family. protein binding cellular_component cytoplasm mitochondrion mitochondrial matrix Golgi apparatus cytosol acetylgalactosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups chondroitin sulfate biosynthetic process Golgi cisterna membrane metal ion binding glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity uc007bpj.1 uc007bpj.2 uc007bpj.3 uc007bpj.4 
ENSMUST00000079206.8 Vmn2r93 ENSMUST00000079206.8 vomeronasal 2, receptor 93 (from RefSeq NM_001104542.1) ENSMUST00000079206.1 ENSMUST00000079206.2 ENSMUST00000079206.3 ENSMUST00000079206.4 ENSMUST00000079206.5 ENSMUST00000079206.6 ENSMUST00000079206.7 L7N1Z9 L7N1Z9_MOUSE NM_001104542 Vmn2r93 uc009vaz.1 uc009vaz.2 uc009vaz.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vaz.1 uc009vaz.2 uc009vaz.3 
ENSMUST00000079213.6 Prpf38a ENSMUST00000079213.6 PRP38 pre-mRNA processing factor 38 (yeast) domain containing A (from RefSeq NM_172697.3) ENSMUST00000079213.1 ENSMUST00000079213.2 ENSMUST00000079213.3 ENSMUST00000079213.4 ENSMUST00000079213.5 NM_172697 PR38A_MOUSE Q4FK66 Q6PB58 Q8BVY2 uc008ubf.1 uc008ubf.2 uc008ubf.3 uc008ubf.4 Involved in pre-mRNA splicing as a component of the spliceosome. Component of the spliceosome B complex. Interacts (via N- terminal interaction domain) with ZMAT2 and MFAP1. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q4FK66-1; Sequence=Displayed; Name=2; IsoId=Q4FK66-2; Sequence=VSP_025425, VSP_025426, VSP_025427; Belongs to the PRP38 family. mRNA splicing, via spliceosome nucleus spliceosomal complex mRNA processing RNA splicing nuclear membrane U2-type precatalytic spliceosome precatalytic spliceosome uc008ubf.1 uc008ubf.2 uc008ubf.3 uc008ubf.4 
ENSMUST00000079223.11 Fggy ENSMUST00000079223.11 FGGY carbohydrate kinase domain containing, transcript variant 1 (from RefSeq NM_001113412.1) A2AJL3 ENSMUST00000079223.1 ENSMUST00000079223.10 ENSMUST00000079223.2 ENSMUST00000079223.3 ENSMUST00000079223.4 ENSMUST00000079223.5 ENSMUST00000079223.6 ENSMUST00000079223.7 ENSMUST00000079223.8 ENSMUST00000079223.9 FGGY_MOUSE NM_001113412 Q8BUF2 Q8K0F0 Q9D7H0 uc008tsy.1 uc008tsy.2 uc008tsy.3 Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities. Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway. Can phosphorylate ribitol with low efficiency. Reaction=ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+); Xref=Rhea:RHEA:17601, ChEBI:CHEBI:15378, ChEBI:CHEBI:17173, ChEBI:CHEBI:30616, ChEBI:CHEBI:58121, ChEBI:CHEBI:456216; EC=2.7.1.47; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17602; Evidence=; Carbohydrate metabolism; pentose and glucuronate interconversion. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AJL3-1; Sequence=Displayed; Name=2; IsoId=A2AJL3-2; Sequence=VSP_032660, VSP_032661; Belongs to the FGGY kinase family. Sequence=BAB26167.1; Type=Erroneous initiation; Evidence=; Sequence=BAC39466.1; Type=Frameshift; Evidence=; cell carbohydrate metabolic process kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor D-ribulokinase activity pentose metabolic process carbohydrate phosphorylation neuron cellular homeostasis uc008tsy.1 uc008tsy.2 uc008tsy.3 
ENSMUST00000079251.8 H2bc8 ENSMUST00000079251.8 H2B clustered histone 8 (from RefSeq NM_178196.4) ENSMUST00000079251.1 ENSMUST00000079251.2 ENSMUST00000079251.3 ENSMUST00000079251.4 ENSMUST00000079251.5 ENSMUST00000079251.6 ENSMUST00000079251.7 H2B1C_MOUSE H2bc4 H2bc6 H2bc8 Hist1h2bc Hist1h2be Hist1h2bg NM_178196 Q6ZWY9 uc007pue.1 uc007pue.2 uc007pue.3 uc007pue.4 uc007pue.5 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome innate immune response in mucosa DNA binding extracellular space nucleus nucleoplasm chromosome cytosol nucleosome assembly antibacterial humoral response identical protein binding protein heterodimerization activity defense response to Gram-positive bacterium uc007pue.1 uc007pue.2 uc007pue.3 uc007pue.4 uc007pue.5 
ENSMUST00000079252.13 Ipmk ENSMUST00000079252.13 inositol polyphosphate multikinase, transcript variant 1 (from RefSeq NM_027184.3) ENSMUST00000079252.1 ENSMUST00000079252.10 ENSMUST00000079252.11 ENSMUST00000079252.12 ENSMUST00000079252.2 ENSMUST00000079252.3 ENSMUST00000079252.4 ENSMUST00000079252.5 ENSMUST00000079252.6 ENSMUST00000079252.7 ENSMUST00000079252.8 ENSMUST00000079252.9 IPMK_MOUSE Impk Ipk2 NM_027184 Q7TT16 Q8BZ11 Q8BZA8 Q9CWM9 uc007fos.1 uc007fos.2 uc007fos.3 Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6- pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:15939867). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (By similarity). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto- inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (By similarity). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (PubMed:15939867). Reaction=1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+); Xref=Rhea:RHEA:32359, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57733, ChEBI:CHEBI:203600, ChEBI:CHEBI:456216; EC=2.7.1.151; Evidence=; Reaction=1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo- inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+); Xref=Rhea:RHEA:12717, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57660, ChEBI:CHEBI:57733, ChEBI:CHEBI:456216; EC=2.7.1.140; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero- 3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo- inositol 3,4,5-triphosphate) + ADP + H(+); Xref=Rhea:RHEA:43396, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77137, ChEBI:CHEBI:83243, ChEBI:CHEBI:456216; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+); Xref=Rhea:RHEA:21292, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57836, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.153; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21293; Evidence=; Reaction=1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo- inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+); Xref=Rhea:RHEA:11856, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57627, ChEBI:CHEBI:57733, ChEBI:CHEBI:456216; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds two Mg(2+), but the interaction with the protein is mostly indirect. ; Phospholipid metabolism; phosphatidylinositol metabolism. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TT16-1; Sequence=Displayed; Name=2; IsoId=Q7TT16-2; Sequence=VSP_010923, VSP_010924; Belongs to the inositol phosphokinase (IPK) family. nucleotide binding inositol-1,4,5-trisphosphate 6-kinase activity inositol tetrakisphosphate 3-kinase activity inositol tetrakisphosphate 6-kinase activity neural tube formation ATP binding nucleus nucleoplasm nucleolus lipid metabolic process inositol-1,4,5-trisphosphate 3-kinase activity kinase activity phosphorylation transferase activity inositol trisphosphate metabolic process inositol phosphate biosynthetic process phosphatidylinositol metabolic process phosphatidylinositol phosphorylation metal ion binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity inositol tetrakisphosphate 5-kinase activity phosphatidylinositol-3,4-bisphosphate 5-kinase activity necroptotic process flavonoid binding uc007fos.1 uc007fos.2 uc007fos.3 
ENSMUST00000079258.7 Numbl ENSMUST00000079258.7 numb-like, transcript variant 2 (from RefSeq NM_010950.3) ENSMUST00000079258.1 ENSMUST00000079258.2 ENSMUST00000079258.3 ENSMUST00000079258.4 ENSMUST00000079258.5 ENSMUST00000079258.6 NM_010950 NUMBL_MOUSE Nbl O08919 Q4QQQ2 Q6NVG8 uc009fvq.1 uc009fvq.2 uc009fvq.3 Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. Interacts (via PTB domain) with MAP3K7IP2 (via C-terminal). Interacts (via C-terminal) with TRAF6 (via TRAF domains) (By similarity). Associates with EPS15 and NOTCH1. Cytoplasm Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS. Preferentially expressed in the nervous system. In the developing neocortex, expressed in postmitotic neurons in the cortical plate but not in progenitors within the ventricular zone. Expressed in neural progenitor and neuron cells throughout the developing nervous system. Expressed in somites and throughout the neural tube from 8.5 dpc, onward. The PTB domain is necessary for the inhibition of MAP3K7IP2- mediated activation of NF-kappa-B. No visible phenotype. Mutants are viable and fertile. Mice lacking both Numb and Numbl genes die around 9.5 dpc, with severe defects in somite and vasculature formation, neuronal tube closure and axial turning. Conditional double-knockout (cdKO) mutants (Numb and Numbl genes), with expression abrogated in neural progenitor cells from 8.5 dpc (just before the onset of neurogenesis), display a loss of neural progenitor cells formation and an overexpression of neurons as neurogenesis progresses; cdKO mutants become necrotic at 12.5 dpc and die around this stage. Conditional double-knockout (cdKO) mutants (Numb and Numbl genes), with expression abrogated in neural progenitor cells from 10.5 dpc (just after the onset of neurogenesis), display a premature depletion of neural progenitor cells in the dorsal forebrain ventrical zone of the neocortex and in the hippocampal CA fields as neurogenesis progresses; cdKO mutants are viable and fertile, but showed a reduction in the thickness of the neocortex and the hippocampus and an enlargement of the lateral ventricles. Tamoxifen- inducible double-knockout (cdKO) mutants (Numb and Numbl genes), with expression abrogated postnatally in the subventricular zone (SVZ) neuroprogenitors and in ependymal cells, display a loss of SVZ neuroblasts and show a disorganized ependyma lacking both interdigitation junction between neighboring cells and increasing number of separated cells. cytoplasm multicellular organism development nervous system development neuroblast proliferation axonogenesis cytokine-mediated signaling pathway protein metabolic process lateral ventricle development neuroblast division in subventricular zone forebrain development adherens junction organization cadherin binding positive regulation of neurogenesis positive regulation of dendrite morphogenesis uc009fvq.1 uc009fvq.2 uc009fvq.3 
ENSMUST00000079268.9 Cyp3a57 ENSMUST00000079268.9 cytochrome P450, family 3, subfamily a, polypeptide 57 (from RefSeq NM_001100180.2) Cyp3a57 D3YYZ0 D3YYZ0_MOUSE ENSMUST00000079268.1 ENSMUST00000079268.2 ENSMUST00000079268.3 ENSMUST00000079268.4 ENSMUST00000079268.5 ENSMUST00000079268.6 ENSMUST00000079268.7 ENSMUST00000079268.8 NM_001100180 uc009amu.1 uc009amu.2 uc009amu.3 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence= Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane eripheral membrane protein Membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding steroid metabolic process testosterone 16-alpha-hydroxylase activity steroid hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding metal ion binding testosterone 6-beta-hydroxylase activity oxidation-reduction process oxidative demethylation uc009amu.1 uc009amu.2 uc009amu.3 
ENSMUST00000079278.5 Nrsn2 ENSMUST00000079278.5 neurensin 2, transcript variant 3 (from RefSeq NM_001370750.1) A2AS81 ENSMUST00000079278.1 ENSMUST00000079278.2 ENSMUST00000079278.3 ENSMUST00000079278.4 Gm123 NM_001370750 NRSN2_MOUSE Nrsn2 Q3USR0 Q5HZK2 uc008nfh.1 uc008nfh.2 uc008nfh.3 May play a role in maintenance and/or transport of vesicles. Membrane ; Multi-pass membrane protein Expressed specifically in brain where it is widely expressed, with highest levels of expression in thalamus and hypothalamus. In brain, found in neural cell bodies and detected in many regions of the limbic system, such as the septum nucleus, horizontal and vertical limbs of the diagonal band, hippocampus, amygdaloid nucleus, and habernula nucleus. Also localizes to small vesicles found in the perinuclear region of Neuro2a and PC12 cells. In cerebral cortex first detected at 15.5 dpc with increasing levels of expression observed during postnatal stages. Belongs to the VMP family. Sequence=BAE24271.1; Type=Frameshift; Evidence=; molecular_function plasma membrane nervous system development membrane integral component of membrane transport vesicle cytoplasmic vesicle neuron projection neuronal cell body uc008nfh.1 uc008nfh.2 uc008nfh.3 
ENSMUST00000079279.4 Gm10118 ENSMUST00000079279.4 Gm10118 (from geneSymbol) AK046912 ENSMUST00000079279.1 ENSMUST00000079279.2 ENSMUST00000079279.3 uc287rtx.1 uc287rtx.2 uc287rtx.1 uc287rtx.2 
ENSMUST00000079286.4 S100a7a ENSMUST00000079286.4 S100 calcium binding protein A7A (from RefSeq NM_199422.1) ENSMUST00000079286.1 ENSMUST00000079286.2 ENSMUST00000079286.3 NM_199422 Q6S5I3 S100a15 S100a15a S100a7 S115A_MOUSE uc008qdc.1 uc008qdc.2 uc008qdc.3 Belongs to the S-100 family. calcium ion binding protein binding extracellular space inflammatory response chemoattractant activity cytokine metabolic process protein self-association metal ion binding transition metal ion binding positive chemotaxis uc008qdc.1 uc008qdc.2 uc008qdc.3 
ENSMUST00000079287.12 Nme5 ENSMUST00000079287.12 NME/NM23 family member 5, transcript variant 1 (from RefSeq NM_080637.4) ENSMUST00000079287.1 ENSMUST00000079287.10 ENSMUST00000079287.11 ENSMUST00000079287.2 ENSMUST00000079287.3 ENSMUST00000079287.4 ENSMUST00000079287.5 ENSMUST00000079287.6 ENSMUST00000079287.7 ENSMUST00000079287.8 ENSMUST00000079287.9 NDK5_MOUSE NM_080637 Q810R1 Q99MH5 uc008eks.1 uc008eks.2 uc008eks.3 Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (PubMed:36417862). Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (PubMed:12788088). Component of the axonemal radial spoke complex 1 (RS1), at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB (PubMed:36417862). Interacts with IQUB (PubMed:36417862). Cell projection, cilium Cytoplasm, cytoskeleton, flagellum axoneme Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q99MH5-1; Sequence=Displayed; Name=2; IsoId=Q99MH5-2; Sequence=VSP_007773, VSP_007774; Expressed in the trachea, ependymal cells and oviduct (at protein level) (PubMed:32203505). Expressed predominantly in germ cells of the testis. Not expressed in testicular somatic cells. First appears in pachytene spermatocytes and increases in abundance in subsequent stages. Belongs to the NDK family. response to reactive oxygen species epithelial cilium movement molecular_function nucleoside diphosphate kinase activity extracellular region nucleoside diphosphate phosphorylation GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process multicellular organism development spermatogenesis spermatid development ventricular system development cell differentiation sperm flagellum spermatid differentiation cilium assembly negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway uc008eks.1 uc008eks.2 uc008eks.3 
ENSMUST00000079300.13 Arhgef26 ENSMUST00000079300.13 Rho guanine nucleotide exchange factor 26 (from RefSeq NM_001081295.1) Arhgef26 D3YYY8 D3YYY8_MOUSE ENSMUST00000079300.1 ENSMUST00000079300.10 ENSMUST00000079300.11 ENSMUST00000079300.12 ENSMUST00000079300.2 ENSMUST00000079300.3 ENSMUST00000079300.4 ENSMUST00000079300.5 ENSMUST00000079300.6 ENSMUST00000079300.7 ENSMUST00000079300.8 ENSMUST00000079300.9 NM_001081295 uc008pjm.1 uc008pjm.2 uc008pjm.3 endothelial cell morphogenesis molecular_function Rho guanyl-nucleotide exchange factor activity cellular_component regulation of Rho protein signal transduction ruffle assembly uc008pjm.1 uc008pjm.2 uc008pjm.3 
ENSMUST00000079306.11 Lypd4 ENSMUST00000079306.11 Ly6/Plaur domain containing 4, transcript variant 1 (from RefSeq NM_182785.4) ENSMUST00000079306.1 ENSMUST00000079306.10 ENSMUST00000079306.2 ENSMUST00000079306.3 ENSMUST00000079306.4 ENSMUST00000079306.5 ENSMUST00000079306.6 ENSMUST00000079306.7 ENSMUST00000079306.8 ENSMUST00000079306.9 LYPD4_MOUSE NM_182785 Q8BVP6 uc009fqo.1 uc009fqo.2 uc009fqo.3 Cell membrane ; Lipid-anchor, GPI- anchor molecular_function cellular_component plasma membrane biological_process membrane anchored component of membrane uc009fqo.1 uc009fqo.2 uc009fqo.3 
ENSMUST00000079323.8 Mctp2 ENSMUST00000079323.8 multiple C2 domains, transmembrane 2 (from RefSeq NM_001024703.1) ENSMUST00000079323.1 ENSMUST00000079323.2 ENSMUST00000079323.3 ENSMUST00000079323.4 ENSMUST00000079323.5 ENSMUST00000079323.6 ENSMUST00000079323.7 Gm489 MCTP2_MOUSE NM_001024703 Q5RJH2 uc009hnp.1 uc009hnp.2 uc009hnp.3 Might play a role in the development of cardiac outflow tract. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds Ca(2+) via the C2 domains in absence of phospholipids. ; Membrane ; Multi-pass membrane protein Expressed at high levels in the developing heart, with high levels at 9.5 dpc that progressively decrease until 11.5 dpc. Belongs to the MCTP family. calcium ion binding nucleoplasm cytosol multicellular organism development membrane integral component of membrane synaptic vesicle membrane regulation of neurotransmitter secretion calcium-dependent phospholipid binding uc009hnp.1 uc009hnp.2 uc009hnp.3 
ENSMUST00000079324.14 Ubl3 ENSMUST00000079324.14 ubiquitin-like 3, transcript variant 1 (from RefSeq NM_011908.2) A4FTW0 ENSMUST00000079324.1 ENSMUST00000079324.10 ENSMUST00000079324.11 ENSMUST00000079324.12 ENSMUST00000079324.13 ENSMUST00000079324.2 ENSMUST00000079324.3 ENSMUST00000079324.4 ENSMUST00000079324.5 ENSMUST00000079324.6 ENSMUST00000079324.7 ENSMUST00000079324.8 ENSMUST00000079324.9 NM_011908 Q3UKM1 Q9Z2M6 UBL3_MOUSE uc009aou.1 uc009aou.2 uc009aou.3 Cell membrane ; Lipid-anchor molecular_function plasma membrane biological_process membrane uc009aou.1 uc009aou.2 uc009aou.3 
ENSMUST00000079362.13 Apc ENSMUST00000079362.13 APC, WNT signaling pathway regulator, transcript variant 3 (from RefSeq NM_007462.4) Apc B2RUG9 B2RUG9_MOUSE ENSMUST00000079362.1 ENSMUST00000079362.10 ENSMUST00000079362.11 ENSMUST00000079362.12 ENSMUST00000079362.2 ENSMUST00000079362.3 ENSMUST00000079362.4 ENSMUST00000079362.5 ENSMUST00000079362.6 ENSMUST00000079362.7 ENSMUST00000079362.8 ENSMUST00000079362.9 NM_007462 uc008eke.1 uc008eke.2 uc008eke.3 uc008eke.4 uc008eke.5 Belongs to the adenomatous polyposis coli (APC) family. mitotic cytokinesis nucleus cytoplasm cellular response to DNA damage stimulus negative regulation of microtubule depolymerization cell cycle arrest beta-catenin binding microtubule binding negative regulation of cell proliferation Wnt signaling pathway cell migration negative regulation of Wnt signaling pathway positive regulation of apoptotic process uc008eke.1 uc008eke.2 uc008eke.3 uc008eke.4 uc008eke.5 
ENSMUST00000079368.5 Adam1b ENSMUST00000079368.5 a disintegrin and metallopeptidase domain 1b (from RefSeq NM_172125.3) ADM1B_MOUSE B2RU57 ENSMUST00000079368.1 ENSMUST00000079368.2 ENSMUST00000079368.3 ENSMUST00000079368.4 NM_172125 Q8R534 Q9R156 uc008zjn.1 uc008zjn.2 uc008zjn.3 May play a role in spermatogenesis and sperm maturation. Heterodimer with ADAM2/fertilin subunit beta. Membrane ; Single-pass type I membrane protein Testis. Expression is detected 20 days after birth and increases gradually up to day 60. metalloendopeptidase activity protein binding proteolysis spermatogenesis peptidase activity metallopeptidase activity membrane integral component of membrane hydrolase activity metal ion binding uc008zjn.1 uc008zjn.2 uc008zjn.3 
ENSMUST00000079376.13 1700104B16Rik ENSMUST00000079376.13 1700104B16Rik (from geneSymbol) AK018937 ENSMUST00000079376.1 ENSMUST00000079376.10 ENSMUST00000079376.11 ENSMUST00000079376.12 ENSMUST00000079376.2 ENSMUST00000079376.3 ENSMUST00000079376.4 ENSMUST00000079376.5 ENSMUST00000079376.6 ENSMUST00000079376.7 ENSMUST00000079376.8 ENSMUST00000079376.9 uc009lkg.1 uc009lkg.2 uc009lkg.3 uc009lkg.4 uc009lkg.1 uc009lkg.2 uc009lkg.3 uc009lkg.4 
ENSMUST00000079379.3 Clec4a4 ENSMUST00000079379.3 C-type lectin domain family 4, member a4 (from RefSeq NM_001005860.2) Clec4a4 Dcir2 ENSMUST00000079379.1 ENSMUST00000079379.2 NM_001005860 Q5YIR8 Q5YIR8_MOUSE uc009dpx.1 uc009dpx.2 uc009dpx.3 uc009dpx.4 cellular_component biological_process membrane integral component of membrane carbohydrate binding metal ion binding carbohydrate derivative binding uc009dpx.1 uc009dpx.2 uc009dpx.3 uc009dpx.4 
ENSMUST00000079390.7 Lin28b ENSMUST00000079390.7 lin-28 homolog B (from RefSeq NM_001031772.2) ENSMUST00000079390.1 ENSMUST00000079390.2 ENSMUST00000079390.3 ENSMUST00000079390.4 ENSMUST00000079390.5 ENSMUST00000079390.6 LN28B_MOUSE NM_001031772 Q3UZC6 Q3V444 Q45KJ6 uc007faa.1 uc007faa.2 uc007faa.3 uc007faa.4 Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. Does not act on pri-miR21. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation. This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent. Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop (By similarity). Mediates MYC-induced let-7 repression (PubMed:19211792). When overexpressed, may stimulate growth of carcinoma cell lines (By similarity). Nucleus, nucleolus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q45KJ6-1; Sequence=Displayed; Name=2; IsoId=Q45KJ6-2; Sequence=VSP_021119; Name=3; IsoId=Q45KJ6-3; Sequence=VSP_021115, VSP_021119, VSP_021120, VSP_021121; Name=4; IsoId=Q45KJ6-4; Sequence=VSP_021116, VSP_021117, VSP_021118; The tandem zinc fingers, also referred as zinc knuckle domain (ZKD), mediate specific binding to the GGAG/GGUG motif while the CSD shows only limited pyrimidine-rich sequence specificity. Both domains bind single-stranded nucleic acids (By similarity). Belongs to the lin-28 family. nucleic acid binding RNA binding nucleus nucleolus cytosol zinc ion binding miRNA catabolic process gene silencing by RNA pre-miRNA processing RNA 3'-end processing metal ion binding uc007faa.1 uc007faa.2 uc007faa.3 uc007faa.4 
ENSMUST00000079400.6 Aspg ENSMUST00000079400.6 asparaginase (from RefSeq NM_001081169.1) A0JNU3 ENSMUST00000079400.1 ENSMUST00000079400.2 ENSMUST00000079400.3 ENSMUST00000079400.4 ENSMUST00000079400.5 LPP60_MOUSE NM_001081169 uc007pek.1 uc007pek.2 uc007pek.3 Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero- 3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl- GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3- phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (By similarity). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (By similarity). Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15178; Evidence=; Reaction=H2O + L-asparagine = L-aspartate + NH4(+); Xref=Rhea:RHEA:21016, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29991, ChEBI:CHEBI:58048; EC=3.5.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21017; Evidence=; Reaction=a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O- alkyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:17777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707; EC=3.1.1.47; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17778; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=2 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2- dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3- phosphocholine; Xref=Rhea:RHEA:40879, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40880; Evidence=; Reaction=1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + octadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40887, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:25629, ChEBI:CHEBI:73858; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40888; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)- octadecenoate + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40807, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28610, ChEBI:CHEBI:30823; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40808; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:40891, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73004, ChEBI:CHEBI:143890; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40892; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:40895, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74971, ChEBI:CHEBI:143890; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40896; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl- sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3- phosphoethanolamine + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40899, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998, ChEBI:CHEBI:73004, ChEBI:CHEBI:73005; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40900; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3- phosphocholine; Xref=Rhea:RHEA:40827, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:32395, ChEBI:CHEBI:76079; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40828; Evidence=; Reaction=2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40903, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:76078; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40904; Evidence=; Reaction=2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2- dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3- phosphocholine; Xref=Rhea:RHEA:40907, ChEBI:CHEBI:16870, ChEBI:CHEBI:72999, ChEBI:CHEBI:76078; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40908; Evidence=; Reaction=1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41320, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:78044, ChEBI:CHEBI:78045; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41321; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn- glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-hexadecanoyl-sn- glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:41352, ChEBI:CHEBI:16870, ChEBI:CHEBI:64771, ChEBI:CHEBI:64874, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41353; Evidence=; Reaction=2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3- phosphocholine = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40959, ChEBI:CHEBI:16870, ChEBI:CHEBI:60657, ChEBI:CHEBI:76079; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40960; Evidence=; Monomer. In the N-terminal section; belongs to the asparaginase 1 family. 1-alkyl-2-acetylglycerophosphocholine esterase activity asparaginase activity lysophospholipase activity cellular amino acid metabolic process asparagine metabolic process lipid metabolic process phospholipid metabolic process lipid catabolic process transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups hydrolase activity uc007pek.1 uc007pek.2 uc007pek.3 
ENSMUST00000079403.11 Pgghg ENSMUST00000079403.11 protein glucosylgalactosylhydroxylysine glucosidase, transcript variant 1 (from RefSeq NM_145387.5) Athl1 ENSMUST00000079403.1 ENSMUST00000079403.10 ENSMUST00000079403.2 ENSMUST00000079403.3 ENSMUST00000079403.4 ENSMUST00000079403.5 ENSMUST00000079403.6 ENSMUST00000079403.7 ENSMUST00000079403.8 ENSMUST00000079403.9 NM_145387 PGGHG_MOUSE Pgghg Q571E9 Q8BP56 Q8R585 uc009kiw.1 uc009kiw.2 uc009kiw.3 Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. Reaction=(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5- hydroxy-L-lysyl-[collagen] + H2O = (5R)-5-O-(beta-D-galactosyl)-5- hydroxy-L-lysyl-[collagen] + D-glucose; Xref=Rhea:RHEA:11068, Rhea:RHEA-COMP:12753, Rhea:RHEA-COMP:12754, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:133443, ChEBI:CHEBI:133452; EC=3.2.1.107; Evidence=; Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BP56-1; Sequence=Displayed; Name=2; IsoId=Q8BP56-2; Sequence=VSP_032897, VSP_032898, VSP_032899; Name=3; IsoId=Q8BP56-3; Sequence=VSP_032900; Belongs to the glycosyl hydrolase 65 family. Sequence=BAD90165.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; catalytic activity hydrolase activity, hydrolyzing O-glycosyl compounds cytosol carbohydrate metabolic process metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds protein-glucosylgalactosylhydroxylysine glucosidase activity uc009kiw.1 uc009kiw.2 uc009kiw.3 
ENSMUST00000079405.15 Zfp239 ENSMUST00000079405.15 zinc finger protein 239, transcript variant 2 (from RefSeq NM_008616.4) ENSMUST00000079405.1 ENSMUST00000079405.10 ENSMUST00000079405.11 ENSMUST00000079405.12 ENSMUST00000079405.13 ENSMUST00000079405.14 ENSMUST00000079405.2 ENSMUST00000079405.3 ENSMUST00000079405.4 ENSMUST00000079405.5 ENSMUST00000079405.6 ENSMUST00000079405.7 ENSMUST00000079405.8 ENSMUST00000079405.9 Mok-2 Mok2 NM_008616 P24399 Q99J71 ZN239_MOUSE Znf239 uc009dld.1 uc009dld.2 uc009dld.3 uc009dld.4 May be involved in transcriptional regulation. Nucleus Preferentially expressed in transformed mouse cells. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus metal ion binding uc009dld.1 uc009dld.2 uc009dld.3 uc009dld.4 
ENSMUST00000079414.12 Cep89 ENSMUST00000079414.12 centrosomal protein 89, transcript variant 1 (from RefSeq NM_028120.3) CEP89_MOUSE Ccdc123 ENSMUST00000079414.1 ENSMUST00000079414.10 ENSMUST00000079414.11 ENSMUST00000079414.2 ENSMUST00000079414.3 ENSMUST00000079414.4 ENSMUST00000079414.5 ENSMUST00000079414.6 ENSMUST00000079414.7 ENSMUST00000079414.8 ENSMUST00000079414.9 NM_028120 Q8C127 Q9CZX2 uc009gjv.1 uc009gjv.2 uc009gjv.3 Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity (By similarity). Cytoplasm, cytosol Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Mitochondrion intermembrane space Note=Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Sequence=BAC26301.1; Type=Frameshift; Evidence=; spindle pole protein binding cytoplasm mitochondrion mitochondrial intermembrane space centrosome centriole microtubule organizing center cytosol cytoskeleton plasma membrane mitochondrion organization chemical synaptic transmission cell projection organization motile cilium cilium assembly ciliary transition fiber non-motile cilium non-motile cilium assembly uc009gjv.1 uc009gjv.2 uc009gjv.3 
ENSMUST00000079421.15 Daxx ENSMUST00000079421.15 Fas death domain-associated protein, transcript variant 4 (from RefSeq NR_149750.1) Daxx ENSMUST00000079421.1 ENSMUST00000079421.10 ENSMUST00000079421.11 ENSMUST00000079421.12 ENSMUST00000079421.13 ENSMUST00000079421.14 ENSMUST00000079421.2 ENSMUST00000079421.3 ENSMUST00000079421.4 ENSMUST00000079421.5 ENSMUST00000079421.6 ENSMUST00000079421.7 ENSMUST00000079421.8 ENSMUST00000079421.9 NR_149750 Q3UKR0 Q3UKR0_MOUSE uc008caa.1 uc008caa.2 uc008caa.3 Chromosome, centromere Cytoplasm Nucleus, PML body Nucleus, nucleolus Nucleus, nucleoplasm Belongs to the DAXX family. chromosome, centromeric region positive regulation of protein phosphorylation p53 binding transcription coactivator activity transcription corepressor activity nucleus nucleosome assembly chromatin remodeling regulation of transcription, DNA-templated nuclear body PML body enzyme binding protein kinase binding protein kinase activator activity androgen receptor signaling pathway regulation of protein ubiquitination ubiquitin protein ligase binding activation of protein kinase activity SUMO binding cellular response to heat cellular response to unfolded protein histone binding positive regulation of protein kinase activity negative regulation of transcription, DNA-templated protein heterodimerization activity protein N-terminus binding androgen receptor binding cellular response to cadmium ion cellular response to copper ion cellular response to diamide positive regulation of neuron death positive regulation of nucleic acid-templated transcription cellular response to sodium arsenite uc008caa.1 uc008caa.2 uc008caa.3 
ENSMUST00000079423.7 Tlcd3b ENSMUST00000079423.7 TLC domain containing 3B, transcript variant 1 (from RefSeq NM_029978.1) ENSMUST00000079423.1 ENSMUST00000079423.2 ENSMUST00000079423.3 ENSMUST00000079423.4 ENSMUST00000079423.5 ENSMUST00000079423.6 Fam57b NM_029978 Q3V2R2 Q561N3 Q7TNV1 Q9CW26 TLC3B_MOUSE uc009jsy.1 uc009jsy.2 uc009jsy.3 uc009jsy.4 Involved in ceramide synthesis. In vitro, isoform 3 stimulates the production of C16-, C18- and C20-ceramides, isoform 1 slightly increases the levels of C18- and C20-ceramides, while isoform 2 exhibits only minimal activity. May interfere with adipogenesis by stimulating ceramide synthesis. Reaction=octadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N- octadecanoylsphing-4-enine; Xref=Rhea:RHEA:36691, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57756, ChEBI:CHEBI:72961; Evidence=; Reaction=eicosanoyl-CoA + sphing-4-enine = CoA + H(+) + N-eicosanoyl- sphing-4-enine; Xref=Rhea:RHEA:45284, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:57756, ChEBI:CHEBI:72962; Evidence=; Reaction=hexadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N- hexadecanoylsphing-4-enine; Xref=Rhea:RHEA:36687, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57756, ChEBI:CHEBI:72959; Evidence=; [Isoform 1]: Golgi apparatus membrane ; Multi-pass membrane protein [Isoform 2]: Endoplasmic reticulum membrane ; Multi-pass membrane protein [Isoform 3]: Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative promoter usage; Named isoforms=3; Name=1; IsoId=Q7TNV1-1; Sequence=Displayed; Name=2; IsoId=Q7TNV1-2; Sequence=VSP_021637; Name=3; IsoId=Q7TNV1-3; Sequence=VSP_021636; Each isoform has a distinct expression pattern. Isoform 1 is highly expressed in brain. Isoform 2 is expressed at low levels, if any, in all analyzed tissues, with slightly higher levels in testis. Isoform 3 is expressed at very high levels in testis and, at lower levels, in white adipose tissue. In epididymal fat, isoform 3 is expressed at higher levels in obese mice compared with lean mice. By contrast, isoform 1 and 2 levels are significantly lower in obese mice compared with lean mice. Up-regulated during adipogenesis. [Isoform 3]: Strongly up-regulated by PPARG. Knockout mice exhibit a significant reduction of the cone photoreceptor light responses, thinning of the outer nuclear layer, and loss of cone photoreceptors across the retina compared with wild-type animals (PubMed:33077892). Knockout male mice are fertile (PubMed:33077892). Sequence=BAB23923.1; Type=Frameshift; Evidence=; Golgi membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus lipid metabolic process membrane integral component of membrane transferase activity negative regulation of fat cell differentiation ceramide biosynthetic process sphingosine N-acyltransferase activity uc009jsy.1 uc009jsy.2 uc009jsy.3 uc009jsy.4 
ENSMUST00000079439.10 Tmem91 ENSMUST00000079439.10 transmembrane protein 91, transcript variant 1 (from RefSeq NM_177102.4) ENSMUST00000079439.1 ENSMUST00000079439.2 ENSMUST00000079439.3 ENSMUST00000079439.4 ENSMUST00000079439.5 ENSMUST00000079439.6 ENSMUST00000079439.7 ENSMUST00000079439.8 ENSMUST00000079439.9 NM_177102 Q8C581 SynDIG3 TMM91_MOUSE uc009ftk.1 uc009ftk.2 uc009ftk.3 uc009ftk.4 Membrane ; Multi-pass membrane protein Belongs to the CD225/Dispanin family. hematopoietic progenitor cell differentiation molecular_function cellular_component membrane integral component of membrane uc009ftk.1 uc009ftk.2 uc009ftk.3 uc009ftk.4 
ENSMUST00000079447.4 Speer4a1 ENSMUST00000079447.4 spermatogenesis associated glutamate (E)-rich protein 4A1 (from RefSeq NM_029376.2) ENSMUST00000079447.1 ENSMUST00000079447.2 ENSMUST00000079447.3 F8VPX6 F8VPX6_MOUSE NM_029376 Speer4a uc008wte.1 uc008wte.2 uc008wte.3 molecular_function cellular_component biological_process uc008wte.1 uc008wte.2 uc008wte.3 
ENSMUST00000079472.4 Aadat ENSMUST00000079472.4 aminoadipate aminotransferase (from RefSeq NM_011834.2) AADAT_MOUSE Aadat ENSMUST00000079472.1 ENSMUST00000079472.2 ENSMUST00000079472.3 Kat2 NM_011834 Q9WVM8 uc009lte.1 uc009lte.2 uc009lte.3 Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). Reaction=2-oxoglutarate + L-kynurenine = H2O + kynurenate + L- glutamate; Xref=Rhea:RHEA:65560, ChEBI:CHEBI:15377, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454; EC=2.6.1.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65561; Evidence=; Reaction=2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L- glutamate; Xref=Rhea:RHEA:12601, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57499, ChEBI:CHEBI:58672; EC=2.6.1.39; Evidence=; Reaction=2-oxoglutarate + glycine = glyoxylate + L-glutamate; Xref=Rhea:RHEA:14089, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305; EC=2.6.1.4; Evidence=; Reaction=glyoxylate + L-kynurenine = glycine + H2O + kynurenate; Xref=Rhea:RHEA:65896, ChEBI:CHEBI:15377, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454; EC=2.6.1.63; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65897; Evidence=; Reaction=3-hydroxy-L-kynurenine + glyoxylate = glycine + H2O + xanthurenate; Xref=Rhea:RHEA:65900, ChEBI:CHEBI:15377, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:58125, ChEBI:CHEBI:71201; EC=2.6.1.63; Evidence=; Reaction=2-oxohexanoate + L-kynurenine = H2O + kynurenate + L-2- aminohexanoate; Xref=Rhea:RHEA:66060, ChEBI:CHEBI:15377, ChEBI:CHEBI:35177, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454, ChEBI:CHEBI:58455; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66061; Evidence=; Reaction=3-phenylpyruvate + L-kynurenine = H2O + kynurenate + L- phenylalanine; Xref=Rhea:RHEA:66092, ChEBI:CHEBI:15377, ChEBI:CHEBI:18005, ChEBI:CHEBI:57959, ChEBI:CHEBI:58095, ChEBI:CHEBI:58454; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66093; Evidence=; Reaction=4-methylsulfanyl-2-oxobutanoate + L-kynurenine = H2O + kynurenate + L-methionine; Xref=Rhea:RHEA:69096, ChEBI:CHEBI:15377, ChEBI:CHEBI:16723, ChEBI:CHEBI:57844, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69097; Evidence=; Reaction=2-oxo-3-sulfanylpropanoate + L-kynurenine = H2O + kynurenate + L-cysteine; Xref=Rhea:RHEA:69104, ChEBI:CHEBI:15377, ChEBI:CHEBI:35235, ChEBI:CHEBI:57678, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69105; Evidence=; Reaction=indole-3-pyruvate + L-kynurenine = H2O + kynurenate + L- tryptophan; Xref=Rhea:RHEA:66052, ChEBI:CHEBI:15377, ChEBI:CHEBI:17640, ChEBI:CHEBI:57912, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66053; Evidence=; Reaction=2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-2- aminopentanoate; Xref=Rhea:RHEA:66076, ChEBI:CHEBI:15377, ChEBI:CHEBI:28644, ChEBI:CHEBI:57959, ChEBI:CHEBI:58441, ChEBI:CHEBI:58454; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66077; Evidence=; Reaction=4-methyl-2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-leucine; Xref=Rhea:RHEA:66068, ChEBI:CHEBI:15377, ChEBI:CHEBI:17865, ChEBI:CHEBI:57427, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66069; Evidence=; Reaction=glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine; Xref=Rhea:RHEA:22884, ChEBI:CHEBI:16723, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:57844; EC=2.6.1.73; Evidence=; Reaction=glyoxylate + L-2-aminoadipate = 2-oxoadipate + glycine; Xref=Rhea:RHEA:69112, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:57499, ChEBI:CHEBI:58672; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69113; Evidence=; Reaction=glyoxylate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + glycine; Xref=Rhea:RHEA:69116, ChEBI:CHEBI:36242, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:58315; Evidence=; Reaction=glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine; Xref=Rhea:RHEA:69120, ChEBI:CHEBI:18005, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:58095; Evidence=; Reaction=glyoxylate + L-tryptophan = glycine + indole-3-pyruvate; Xref=Rhea:RHEA:69124, ChEBI:CHEBI:17640, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:57912; Evidence=; Reaction=glyoxylate + L-leucine = 4-methyl-2-oxopentanoate + glycine; Xref=Rhea:RHEA:69128, ChEBI:CHEBI:17865, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:57427; Evidence=; Reaction=2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + H2O + kynurenate; Xref=Rhea:RHEA:66044, ChEBI:CHEBI:15377, ChEBI:CHEBI:16763, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454, ChEBI:CHEBI:74359; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66045; Evidence=; Reaction=2-oxoadipate + L-kynurenine = H2O + kynurenate + L-2- aminoadipate; Xref=Rhea:RHEA:70047, ChEBI:CHEBI:15377, ChEBI:CHEBI:57499, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454, ChEBI:CHEBI:58672; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70048; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6. Homodimer. Mitochondrion Expressed mainly in kidney and to a lesser amount in liver and brain. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. catalytic activity mitochondrion 2-oxoglutarate metabolic process glutamate metabolic process transaminase activity biosynthetic process kynurenine-oxoglutarate transaminase activity transferase activity pyridoxal phosphate binding L-lysine catabolic process to acetyl-CoA via saccharopine protein homodimerization activity 2-aminoadipate transaminase activity kynurenine metabolic process L-kynurenine metabolic process alpha-amino acid metabolic process uc009lte.1 uc009lte.2 uc009lte.3 
ENSMUST00000079476.10 Nlrp3 ENSMUST00000079476.10 NLR family, pyrin domain containing 3, transcript variant 2 (from RefSeq NM_001359638.1) Cias1 ENSMUST00000079476.1 ENSMUST00000079476.2 ENSMUST00000079476.3 ENSMUST00000079476.4 ENSMUST00000079476.5 ENSMUST00000079476.6 ENSMUST00000079476.7 ENSMUST00000079476.8 ENSMUST00000079476.9 Mmig1 NLRP3_MOUSE NM_001359638 Nalp3 Nlrp3 Pypaf1 Q1JQ87 Q1JQ88 Q6JEL0 Q8R4B8 T1W2H6 uc007jeh.1 uc007jeh.2 uc007jeh.3 Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:19362020, PubMed:23582325, PubMed:26814970, PubMed:27929086, PubMed:26642356, PubMed:27374331, PubMed:28847925, PubMed:28656979, PubMed:30518920, PubMed:36178239). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:19362020, PubMed:16407889, PubMed:18403674, PubMed:26814970, PubMed:26642356, PubMed:27374331, PubMed:28847925). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:16546100, PubMed:17008311, PubMed:26814970, PubMed:26642356, PubMed:27374331, PubMed:28847925). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (By similarity). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid- beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407888, PubMed:16407890, PubMed:16407889, PubMed:18403674, PubMed:19362020, PubMed:37001519). Almost all stimuli trigger intracellular K(+) efflux (PubMed:23809161). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:26814970, PubMed:34615873, PubMed:34861190). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600). Shows ATPase activity (PubMed:34861190). Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell- dependent asthma and tumor growth (PubMed:26098997). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (PubMed:26098997). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (PubMed:26098997). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (PubMed:26098997). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Under resting conditions, NLRP3 binds ADP and is autoinhibited (By similarity). Inactive NLRP3 forms homodecameric double-ring cages that hide pyrin domains within NACHT-LRR rings to avoid premature activation (PubMed:30518920, PubMed:34861190, PubMed:35254907). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:19362020). Almost all stimuli trigger intracellular K(+) efflux (PubMed:23809161). These stimuli lead to membrane perturbations that induce activation of NLRP3 (PubMed:34861190). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and recruitment of PYCARD/ASC for the formation of an active inflammasome complex (PubMed:26814970, PubMed:26642356, PubMed:28716882, PubMed:30487600, PubMed:34615873, PubMed:34861190). NEK7-activated NLRP3 forms a disk-shaped inflammasome (By similarity). NLRP3 and PYCARD/ASC interact via their respective pyrin domains; interaction initiates speck formation (nucleation) which greatly enhances further addition of soluble PYCARD/ASC molecules to the speck in a prion-like polymerization process (PubMed:24630723). Clustered PYCARD/ASC nucleates the formation of CASP1 filaments through the interaction of their respective CARD domains, acting as a platform for CASP1 polymerization and activation (By similarity). Active CASP1 then processes IL1B and IL18 precursors, leading to the release of mature cytokines in the extracellular milieu and inflammatory response (By similarity). NLRP3 inflammasome assembly is inhibited by IRGM, which impedes NLRP3 oligomerization (By similarity). Specifically inhibited by sulfonylurea MCC950 (also named CP-456,773, CRID3), a potent and specific small-molecule inhibitor of the NLRP3 inflammasome that acts by preventing ATP hydrolysis (PubMed:35254907). Sensor component of NLRP3 inflammasomes; inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:34861190). The core of NLRP3 inflammasomes consists of a signal sensor component (NLRP3), an adapter (PYCARD/ASC), which recruits an effector pro-inflammatory caspase (CASP1 and, possibly, CASP4 and CASP5) (PubMed:24630723). Homodecamer; inactive NLRP3 forms homodecameric double-ring cages that hide pyrin domains within NACHT-LRR rings to avoid premature activation (PubMed:34861190, PubMed:35254907). Interacts (via pyrin domain) with PYCARD/ASC (via pyrin domain); interaction is direct (PubMed:17907925, PubMed:30487600). Interacts (via LRR repeat domain) with NEK7 (via N- terminus); the interaction is required for the formation of the complex NLRP3:PYCARD, oligomerization of PYCARD/ASC and activation of CASP1 (PubMed:26642356, PubMed:26814970, PubMed:26553871, PubMed:34615873, PubMed:37001519). Interacts (via LRR repeat domain) with NR4A1/Nur77 (via N-terminus); the interaction is direct, requires activation of NR4A1 by its ligands NBRE-containing dsDNA and lipopolysaccharide, and stimulates the association of NLRP3 with NEK7 for non-canonical NLRP3 inflammasome activation (PubMed:37001519). Interacts with CARD8; leading to inhibit formation of the NLRP3 inflammasome (By similarity). Interacts with MEFV; this interaction targets NLRP3 to degradation by autophagy, hence preventing excessive IL1B- and IL18-mediated inflammation (By similarity). Interacts with EIF2AK2/PKR; this interaction requires EIF2AK2 activity, is accompanied by EIF2AK2 autophosphorylation and promotes inflammasome assembly in response to specific stimuli (PubMed:22801494). Interacts with GBP5 (via DAPIN domain); this interaction promotes inflammasome assembly in response to microbial and soluble, but not crystalline, agents (By similarity). Interacts with PML (isoform PML-1) (via the leucine-rich repeat (LRR) domain); PML-mediated increase in NLRP3 inflammasome activation does not depend upon this interaction (By similarity). Interacts (via NACHT domain) with DHX33 (via DEAH box); NLRP3 activation in presence of cytosolic dsRNA is mediated by DHX33 (By similarity). Interacts (via NACHT and LRR domains) with ARRB2; this interaction is direct and inducible by polyunsaturated fatty acids (PUFAs) (By similarity). Interacts (via NACHT domain) with DDX3X under both LPS-primed and inflammasome-activating conditions (PubMed:31511697). Interacts with IRF4 (via the LRR domain); this interaction is direct and is required for optimal IRF4 binding to IL4 promoter and efficient IL4 transactivation during differentiation of Th2 helper T-cells (PubMed:26098997). Interacts with MAVS; promoting localization to mitochondria and activation of the NLRP3 inflammasome (PubMed:23582325). Interacts with MARK4; promoting localization of NLRP3 to the microtubule organizing center (MTOC) (PubMed:28656979). Interacts with TRIM50; this interaction promotes also NLRP3 oligomerization and subsequent inflammasome activation (PubMed:36178239). Interacts with IRGM; preventing NLRP3 inflammasome assembly and promoting NLRP3 degradation (By similarity). Interacts (via KFERQ-like motifs) with HSPA8/HSC70; promoting NLRP3 degradation by the chaperone-mediated autophagy pathway (By similarity). Q8R4B8; Q03963: Eif2ak2; NbExp=3; IntAct=EBI-6910832, EBI-2603444; Q8R4B8; Q9ES74: Nek7; NbExp=2; IntAct=EBI-6910832, EBI-16193749; Q8R4B8; Q9EPB4: Pycard; NbExp=3; IntAct=EBI-6910832, EBI-6253348; Cytoplasm, cytosol flammasome toplasm, cytoskeleton, microtubule organizing center lgi apparatus membrane Endoplasmic reticulum Mitochondrion Secreted Nucleus Note=In macrophages, under resting conditions, mainly located in the cytosol and on membranes of various organelles, such as endoplasmic reticulum, mitochondria and Golgi: forms an inactive double-ring cage that is primarily localized on membranes (PubMed:23502856, PubMed:28716882, PubMed:34861190). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes for the formation of an active inflammasome complex (PubMed:34861190). Recruited to dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600). After the induction of pyroptosis, inflammasome specks are released into the extracellular space where they can further promote IL1B processing and where they can be engulfed by macrophages. Phagocytosis induces lysosomal damage and inflammasome activation in the recipient cells (PubMed:24952505, PubMed:24952504). In the Th2 subset of CD4(+) helper T-cells, mainly located in the nucleus (PubMed:26098997). Nuclear localization depends upon KPNA2 (PubMed:26098997). In the Th1 subset of CD4(+) helper T- cells, mainly cytoplasmic (PubMed:26098997). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=MMIG-1a ; IsoId=Q8R4B8-1; Sequence=Displayed; Name=2; Synonyms=MMIG-1b ; IsoId=Q8R4B8-2; Sequence=VSP_014927; Name=3; Synonyms=MMIG-1c ; IsoId=Q8R4B8-3; Sequence=VSP_014925; Name=4; Synonyms=MMIG-1d ; IsoId=Q8R4B8-4; Sequence=VSP_014926; Expressed with high levels in peripheral blood leukocytes, including Th2 lymphocytes and macrophages (PubMed:15302403, PubMed:26098997, PubMed:16546100, PubMed:28847925). Expressed at low levels in resting osteoblasts (at protein level) (PubMed:17907925). Up-regulated during CD4(+) T-lymphocyte differentiation, in Th0, Th1 and Th2 cells. Not detected in naive CD4(+) T-lymphocytes (at protein level). By activators of Toll-like receptors, such as lipoteichoic acid (LTA) (TLR2), polyinosine-polycytidylic acid (poly(I:C), a synthetic analog of dsRNA) (TLR3) and bacterial lipopolysaccharides (LPS) (TLR4) (PubMed:16546100). Up-regulated by IL2 via STAT5 signaling (PubMed:26098997). Slightly up-regulated in osteoblasts after exposure to invasive, but not invasion-defective, strains of Salmonella typhimurium (at protein level) (PubMed:17907925). The pyrin domain (also called DAPIN domain or PYD) is involved in PYCARD/ASC-binding. The FISNA domain is a critical mediator of NLRP3 conformational during NLRP3 activation. It becomes ordered in its key regions during activation to stabilize the active NACHT conformation and mediate most interactions in the NLRP3 disk. The LRR domain mediates the interaction with IRF4, PML, NEK7 and NR4A1/Nur77. The KFERQ-like motifs mediate binding to HSPA8/HSC70 following NLRP3 paylmitoylation by ZDHHC12. Phosphorylation at Ser-194 by MAPK8/JNK1 increases inflammasome activation by promoting deubiquitination by BRCC3 and NLRP3 homooligomerization (PubMed:28943315). Phosphorylation at Ser-803 by CSNK1A1 prevents inflammasome activation by preventing NEK7 recruitment (PubMed:34615873). Phosphorylation at Ser-3 in the pyrin domain inhibits homomultimerization of NLRP3 and activation of the NLRP3 inflammasome: dephosphorylation by protein phosphatase 2A (PP2A) promotes assembly of the NLRP3 inflammasome (PubMed:28465465). Phosphorylation at Ser-291 by PKD/PRKD1 promotes NLRP3 inflammasome assembly (PubMed:28716882). Phosphorylation by ERK1/MAPK3 promotes NLRP3 inflammasome assembly (By similarity). Phosphorylation by BTK (at Tyr-132, Tyr-136, Tyr-145 and Tyr-164) in the region that mediates binding to phosphatidylinositol phosphate, promotes relocalization of NLRP3 and assembly of the NLRP3 inflammasome (PubMed:34554188). Phosphorylation at Tyr-858 inhibits NLRP3 inflammasome assembly: dephosphorylation by PTPN22 promotes inflammasome activation (PubMed:27043286). Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:23246432). Ubiquitination does not lead to degradation, but inhibits inflammasome activation (PubMed:23246432). Deubiquitination is catalyzed by BRCC3 and associated with NLRP3 activation and inflammasome assembly (PubMed:23246432). This process can be induced by the activation of Toll-like receptors (by LPS), through a non-transcriptional pathway dependent on the mitochondrial production of reactive oxygen species, and by ATP (PubMed:22948162). Ubiquitinated by TRIM31 via 'Lys-48'-linked ubiquitination, leading to its degradation by the proteasome (PubMed:27929086). Ubiquitinated at Lys-687 by the SCF(FBXL2) complex, leading to its degradation by the proteasome (By similarity). Ubiquitinated by TRIM35 via 'lys-48' and 'Lys-63'-linked ubiquitination leading to inhibition of NLRP3 inflammasome activation (By similarity). The disulfide bond in the pyrin domain might play a role in reactive oxygen species-mediated activation. Palmitoylation by ZDHHC12 inhibits the NLRP3 inflammasome by promoting NLRP3 degradation by the chaperone-mediated autophagy pathway. Following palmitoylation, HSPA8/HSC70 recognizes and binds the KFERQ-like motifs on NLRP3 and promotes NLRP3 recruitment to lysosomes, where it is degraded via the chaperone-mediated autophagy pathway in a LAMP2-dependent process. Degraded via selective autophagy following interaction with Irgm1. Irgm1 promotes NLRP3 recruitment to autophagosome membranes, promoting its SQSTM1/p62-dependent autophagy-dependent degradation. Knockout mice are fertile and appear healthy when housed in a standard specific pathogen-free environment (PubMed:16407890, PubMed:16407888). They do not exhibit any increase in serum IL1B after administration of R837 (an analog to guanosine and TLR7 agonist) and/or LPS (PubMed:16407890, PubMed:16407888, PubMed:37001519). When challenged with LPS, mutant mice are partially resistant to endotoxic shock (PubMed:16407890, PubMed:16546100, PubMed:37001519). Mutant mice display impaired contact hypersensitivity, a T-cell-mediated cellular immune response to repeated epicutaneous exposure to contact allergens, such as trinitrophenylchloride (PubMed:16546100). In response to asbestos inhalation, mice show diminished recruitment of inflammatory cells to the lungs, paralleled by lower cytokine production (PubMed:18403674). In a model of allergic asthma that promotes strictly Th2 responses, mutant animals show less infiltration of eosinophils and lymphocytes into the lungs than their wild-type counterparts, as well as less accumulation of mucus and lymphoid infiltrates (PubMed:26098997). The concentration of Th2 cell-related cytokines, including IL-5 and IL-4, is also lower in lungs from mutant mice compared to wild-type (PubMed:26098997). Knockout mice develop insulin (INS) resistance in response to high-fat diet (PubMed:23809162). Mutants mice are protected from lung injury and cytokine production induced by human SARS coronavirus-2/SARS-CoV-2 N protein (PubMed:34341353). Belongs to the NLRP family. Golgi membrane nucleotide binding cytokine secretion involved in immune response immune system process negative regulation of acute inflammatory response positive regulation of type 2 immune response protein binding ATP binding extracellular region nucleus cytoplasm endoplasmic reticulum cytosol activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response transcription factor binding negative regulation of NF-kappaB transcription factor activity interleukin-1 beta production interleukin-18 production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production identical protein binding positive regulation of cysteine-type endopeptidase activity involved in apoptotic process sequence-specific DNA binding NLRP3 inflammasome complex assembly innate immune response positive regulation of T-helper 2 cell differentiation positive regulation of transcription from RNA polymerase II promoter interleukin-1 secretion negative regulation of interleukin-1 beta secretion positive regulation of interleukin-1 beta secretion regulation of inflammatory response negative regulation of inflammatory response defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity defense response to virus inflammasome complex cellular response to lipopolysaccharide cellular response to peptidoglycan NLRP3 inflammasome complex negative regulation of NIK/NF-kappaB signaling positive regulation of T-helper 17 cell differentiation positive regulation of T-helper 2 cell cytokine production uc007jeh.1 uc007jeh.2 uc007jeh.3 
ENSMUST00000079490.6 Nap1l3 ENSMUST00000079490.6 nucleosome assembly protein 1-like 3 (from RefSeq NM_138742.1) B1AZU8 ENSMUST00000079490.1 ENSMUST00000079490.2 ENSMUST00000079490.3 ENSMUST00000079490.4 ENSMUST00000079490.5 Mb20 NM_138742 NP1L3_MOUSE O54802 Q794H2 uc009uel.1 uc009uel.2 uc009uel.3 uc009uel.4 Nucleus Cytoplasm Expressed in brain. Belongs to the nucleosome assembly protein (NAP) family. molecular_function cellular_component nucleus cytoplasm nucleosome assembly biological_process uc009uel.1 uc009uel.2 uc009uel.3 uc009uel.4 
ENSMUST00000079496.9 Ube2s ENSMUST00000079496.9 ubiquitin-conjugating enzyme E2S (from RefSeq NM_133777.2) E2epf ENSMUST00000079496.1 ENSMUST00000079496.2 ENSMUST00000079496.3 ENSMUST00000079496.4 ENSMUST00000079496.5 ENSMUST00000079496.6 ENSMUST00000079496.7 ENSMUST00000079496.8 NM_133777 Q3U4V7 Q8CF67 Q921J4 UBE2S_MOUSE uc009eyt.1 uc009eyt.2 uc009eyt.3 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence= Protein modification; protein ubiquitination. Component of the APC/C complex, composed of at least 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Within this complex, directly interacts with ANAPC2 and ANAPC4. Interacts with CDC20, FZR1/CDH1 and VHL. Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome. Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding ubiquitin-protein transferase activity ATP binding anaphase-promoting complex ubiquitin-dependent protein catabolic process cell cycle exit from mitosis free ubiquitin chain polymerization anaphase-promoting complex binding protein ubiquitination transferase activity anaphase-promoting complex-dependent catabolic process protein K29-linked ubiquitination protein K27-linked ubiquitination cell division ubiquitin conjugating enzyme activity protein K63-linked ubiquitination protein K11-linked ubiquitination protein K6-linked ubiquitination positive regulation of ubiquitin protein ligase activity uc009eyt.1 uc009eyt.2 uc009eyt.3 
ENSMUST00000079528.6 Defa17 ENSMUST00000079528.6 defensin, alpha, 17 (from RefSeq NM_001167790.1) DEFA3_MOUSE Defa3 Defcr3 ENSMUST00000079528.1 ENSMUST00000079528.2 ENSMUST00000079528.3 ENSMUST00000079528.4 ENSMUST00000079528.5 NM_001167790 P28310 Q499K7 uc009lbt.1 uc009lbt.2 uc009lbt.3 uc009lbt.4 Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Secreted. Paneth cells of the small bowel. Belongs to the alpha-defensin family. innate immune response in mucosa extracellular region extracellular space defense response antibacterial humoral response response to drug defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc009lbt.1 uc009lbt.2 uc009lbt.3 uc009lbt.4 
ENSMUST00000079534.11 Tacc3 ENSMUST00000079534.11 transforming, acidic coiled-coil containing protein 3, transcript variant 12 (from RefSeq NM_001405360.1) ENSMUST00000079534.1 ENSMUST00000079534.10 ENSMUST00000079534.2 ENSMUST00000079534.3 ENSMUST00000079534.4 ENSMUST00000079534.5 ENSMUST00000079534.6 ENSMUST00000079534.7 ENSMUST00000079534.8 ENSMUST00000079534.9 NM_001405360 Q6NV52 Q6NV52_MOUSE Tacc3 uc290unw.1 uc290unw.2 Cytoplasm Belongs to the TACC family. mitotic spindle organization uc290unw.1 uc290unw.2 
ENSMUST00000079545.6 St6galnac2 ENSMUST00000079545.6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (from RefSeq NM_009180.3) ENSMUST00000079545.1 ENSMUST00000079545.2 ENSMUST00000079545.3 ENSMUST00000079545.4 ENSMUST00000079545.5 NM_009180 P70277 Q3UWG0 Q9DC24 SIA7B_MOUSE Siat7 Siat7b uc007mma.1 uc007mma.2 uc007mma.3 Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins (PubMed:8662927). Shows a preference for N-acetylgalactosamine (GalNAc) residues already modified by the addition of galactose or galactose followed by sialic acid in alpha-2,3 linkage (PubMed:8662927). Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl- (1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D- galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:11136, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133470, ChEBI:CHEBI:140764; EC=2.4.3.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11137; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Highly expressed in lactating mammary gland and adult testis. Lower levels in kidney. Belongs to the glycosyltransferase 29 family. Name=Functional Glycomics Gateway - GTase; Note=ST6GalNAc II; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_651"; Golgi membrane alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Golgi apparatus protein glycosylation protein O-linked glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein sialylation uc007mma.1 uc007mma.2 uc007mma.3 
ENSMUST00000079548.12 Fbxw20 ENSMUST00000079548.12 F-box and WD-40 domain protein 20 (from RefSeq NM_001008428.3) BC085247 ENSMUST00000079548.1 ENSMUST00000079548.10 ENSMUST00000079548.11 ENSMUST00000079548.2 ENSMUST00000079548.3 ENSMUST00000079548.4 ENSMUST00000079548.5 ENSMUST00000079548.6 ENSMUST00000079548.7 ENSMUST00000079548.8 ENSMUST00000079548.9 Fbxw12 Fbxw20 NM_001008428 Q5U467 Q5U467_MOUSE uc009rsd.1 uc009rsd.2 uc009rsd.3 molecular_function cellular_component biological_process uc009rsd.1 uc009rsd.2 uc009rsd.3 
ENSMUST00000079590.7 Myo1a ENSMUST00000079590.7 myosin IA (from RefSeq NM_001081219.2) B2RW65 Bbmi ENSMUST00000079590.1 ENSMUST00000079590.2 ENSMUST00000079590.3 ENSMUST00000079590.4 ENSMUST00000079590.5 ENSMUST00000079590.6 MYO1A_MOUSE Myhl NM_001081219 O88329 uc007hkh.1 uc007hkh.2 uc007hkh.3 uc007hkh.4 Involved in directing the movement of organelles along actin filaments. Phosphorylated by ALPK1. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1). nucleotide binding motor activity actin binding calmodulin binding ATP binding cytoplasm microvillus brush border sensory perception of sound basal plasma membrane actin cytoskeleton basolateral plasma membrane apical plasma membrane lateral plasma membrane myosin complex cell projection organization microvillus assembly growth cone cortical actin cytoskeleton cell leading edge filamentous actin regulation of protein localization neuron projection neuronal cell body plasma membrane raft membrane raft actin filament binding vesicle localization uc007hkh.1 uc007hkh.2 uc007hkh.3 uc007hkh.4 
ENSMUST00000079597.7 Paqr9 ENSMUST00000079597.7 progestin and adipoQ receptor family member IX (from RefSeq NM_198414.3) ENSMUST00000079597.1 ENSMUST00000079597.2 ENSMUST00000079597.3 ENSMUST00000079597.4 ENSMUST00000079597.5 ENSMUST00000079597.6 NM_198414 PAQR9_MOUSE Paqr9 Q3V0N1 Q6TCG2 uc009rbf.1 uc009rbf.2 uc009rbf.3 Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. May be involved in regulating rapid P4 signaling in the nervous system. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone. Homodimer. Cell membrane ; Multi-pass membrane protein Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). Belongs to the ADIPOR family. steroid binding plasma membrane lipid binding membrane integral component of membrane signaling receptor activity uc009rbf.1 uc009rbf.2 uc009rbf.3 
ENSMUST00000079601.13 Etv5 ENSMUST00000079601.13 ets variant 5, transcript variant 2 (from RefSeq NM_023794.2) ENSMUST00000079601.1 ENSMUST00000079601.10 ENSMUST00000079601.11 ENSMUST00000079601.12 ENSMUST00000079601.2 ENSMUST00000079601.3 ENSMUST00000079601.4 ENSMUST00000079601.5 ENSMUST00000079601.6 ENSMUST00000079601.7 ENSMUST00000079601.8 ENSMUST00000079601.9 ETV5_MOUSE NM_023794 Q3TG49 Q8C0F3 Q9CXC9 Q9JHB1 uc007yse.1 uc007yse.2 uc007yse.3 Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. Interacts (via C-terminal) with ZMYM5 (via N-terminal 120 amino acid region). Nucleus In the brain, expressed predominantly in the cerebral cortex, the amygdala and the hypothalamus. Within the cerebral cortex, there is conspicuously high expression in cortical layers 2, 4 and 6 while expression is almost absent from layers 1, 3 and 5. High expression is also observed in the dorsal and ventral endopiriform claustrum. Strong expression is observed in limited parts of the amygdala including the basolateral amygdaloid nucleus, the bed stria terminalis and the central amygdaloid nucleus. Low to moderate levels are found in the hypothalamus while expression is almost absent in the thalamus. Hypothalamic expression is seen in the dorsomedial hypothalamic nucleus and also the central, dorsomedial and ventrolateral parts of the ventromedial hypothalamic nucleus. Strong expression is also identified in the nigrostriatal tract. In the mesencephalon, expression is restricted to the ventral tegmental area including the parabrachial pigmented nucleus. In the hippocampus, strongly expressed in the pyramidal cell layer. Some expression is also found in the lacunosum moleculare layer. Low levels of expression in the cerebellum, including the granular, molecular and Purkinje cell layers. Belongs to the ETS family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm plasma membrane regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter neuromuscular synaptic transmission locomotory behavior cell differentiation cellular response to oxidative stress sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter male germ-line stem cell asymmetric division regulation of synapse organization positive regulation of glial cell proliferation regulation of branching involved in mammary gland duct morphogenesis skeletal muscle acetylcholine-gated channel clustering uc007yse.1 uc007yse.2 uc007yse.3 
ENSMUST00000079611.13 Frg2f1 ENSMUST00000079611.13 FSHD region gene 2 family member 1 (from RefSeq NM_001004178.1) AA415398 ENSMUST00000079611.1 ENSMUST00000079611.10 ENSMUST00000079611.11 ENSMUST00000079611.12 ENSMUST00000079611.2 ENSMUST00000079611.3 ENSMUST00000079611.4 ENSMUST00000079611.5 ENSMUST00000079611.6 ENSMUST00000079611.7 ENSMUST00000079611.8 ENSMUST00000079611.9 Frg2f1 NM_001004178 Q6P3A2 Q6P3A2_MOUSE uc008ump.1 uc008ump.2 uc008ump.3 uc008ump.4 uc008ump.1 uc008ump.2 uc008ump.3 uc008ump.4 
ENSMUST00000079618.11 St8sia5 ENSMUST00000079618.11 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5, transcript variant 2 (from RefSeq NM_153124.3) ENSMUST00000079618.1 ENSMUST00000079618.10 ENSMUST00000079618.2 ENSMUST00000079618.3 ENSMUST00000079618.4 ENSMUST00000079618.5 ENSMUST00000079618.6 ENSMUST00000079618.7 ENSMUST00000079618.8 ENSMUST00000079618.9 NM_153124 Q3TRR3 Q3TRR3_MOUSE St8sia5 uc008frg.1 uc008frg.2 uc008frg.3 uc008frg.4 Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 29 family. Golgi apparatus protein glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups sialylation uc008frg.1 uc008frg.2 uc008frg.3 uc008frg.4 
ENSMUST00000079625.11 Tor3a ENSMUST00000079625.11 torsin family 3, member A (from RefSeq NM_023141.2) Adir ENSMUST00000079625.1 ENSMUST00000079625.10 ENSMUST00000079625.2 ENSMUST00000079625.3 ENSMUST00000079625.4 ENSMUST00000079625.5 ENSMUST00000079625.6 ENSMUST00000079625.7 ENSMUST00000079625.8 ENSMUST00000079625.9 NM_023141 Q3T9Q6 Q3TDA9 Q3U5X1 Q3U8F2 Q9CR17 Q9CU67 Q9ER38 TOR3A_MOUSE uc007dcn.1 uc007dcn.2 uc007dcn.3 uc007dcn.4 Interacts with TOR1AIP1. Cytoplasm. Endoplasmic reticulum lumen At 16 dpc, widely expressed with very low levels in heart, liver and neural tissues. By interferon-alpha and interferon-gamma, in spleen and liver. N-glycosylated. Belongs to the ClpA/ClpB family. Torsin subfamily. nucleotide binding protein binding ATP binding nuclear envelope cytoplasm endoplasmic reticulum endoplasmic reticulum lumen ATPase activity uc007dcn.1 uc007dcn.2 uc007dcn.3 uc007dcn.4 
ENSMUST00000079639.3 Cldn24 ENSMUST00000079639.3 claudin 24 (from RefSeq NM_001111318.1) Cldn24 D3YXJ9 D3YXJ9_MOUSE ENSMUST00000079639.1 ENSMUST00000079639.2 NM_001111318 uc012gdp.1 uc012gdp.2 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is 75% identical to the human homolog. Similar to the human gene, this gene is upstream of the Cldn22 gene, which overlaps the Wwc2 gene on the opposite strand. [provided by RefSeq, Aug 2010]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the claudin family. molecular_function structural molecule activity plasma membrane bicellular tight junction biological_process membrane integral component of membrane apical plasma membrane cell junction uc012gdp.1 uc012gdp.2 
ENSMUST00000079642.8 Zfp119a ENSMUST00000079642.8 zinc finger protein 119a, transcript variant 1 (from RefSeq NM_144546.6) ENSMUST00000079642.1 ENSMUST00000079642.2 ENSMUST00000079642.3 ENSMUST00000079642.4 ENSMUST00000079642.5 ENSMUST00000079642.6 ENSMUST00000079642.7 Mzf13 NM_144546 Q9JIC0 Q9JIC0_MOUSE Zfp119 Zfp119a uc008daf.1 uc008daf.2 uc008daf.3 uc008daf.4 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding nucleus regulation of transcription, DNA-templated metal ion binding uc008daf.1 uc008daf.2 uc008daf.3 uc008daf.4 
ENSMUST00000079644.13 Ybx1 ENSMUST00000079644.13 Y box protein 1 (from RefSeq NM_011732.2) 1700102N10Rik EF1A ENSMUST00000079644.1 ENSMUST00000079644.10 ENSMUST00000079644.11 ENSMUST00000079644.12 ENSMUST00000079644.2 ENSMUST00000079644.3 ENSMUST00000079644.4 ENSMUST00000079644.5 ENSMUST00000079644.6 ENSMUST00000079644.7 ENSMUST00000079644.8 ENSMUST00000079644.9 MSY1 NM_011732 Q3UBT1 Q3UBT1_MOUSE YB-1 Ybx1 dbpB mYB-1a uc008ulu.1 uc008ulu.2 uc008ulu.3 Nucleus Belongs to the YBX1 family. nucleic acid binding uc008ulu.1 uc008ulu.2 uc008ulu.3 
ENSMUST00000079648.12 Uqcc6 ENSMUST00000079648.12 ubiquinol-cytochrome c reductase complex assembly factor 6, transcript variant 1 (from RefSeq NM_001135567.1) Br Brawnin ENSMUST00000079648.1 ENSMUST00000079648.10 ENSMUST00000079648.11 ENSMUST00000079648.2 ENSMUST00000079648.3 ENSMUST00000079648.4 ENSMUST00000079648.5 ENSMUST00000079648.6 ENSMUST00000079648.7 ENSMUST00000079648.8 ENSMUST00000079648.9 NM_001135567 Q8BTC1 UQCC6_MOUSE Uqcc6 uc007gjp.1 uc007gjp.2 uc007gjp.3 uc007gjp.4 Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III or cytochrome b- c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:32161263, PubMed:35977508). Mediates early complex III biogenesis (PubMed:35977508). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (PubMed:35977508). Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity). Interacts with UQCRC1 (PubMed:32161263). Interacts with UQCRQ (PubMed:32161263). Interacts with UQCC5 (By similarity). Forms a complex, named COMB/coordinator of mitochondrial CYTB biogenesis, composed of UQCC1, UQCC2, UQCC4, UQCC5 and UQCC6; stabilizes nascent cytochrome b/MT-CYB and promotes its membrane insertion (PubMed:35977508). Forms a complex, named COMA, composed of UQCC1, UQCC2 and UQCC4; activates MT-CYB translation (PubMed:35977508). Forms a complex, named COMC, composed of UQCC1, UQCC2; UQCC3 and UQCC4; mediates MT-CYB hemylation and association with the first nuclear- encoded complex III subunit UQCRQ (PubMed:35977508). Interacts with MT- CYB (PubMed:35977508). Mitochondrion inner membrane ; Single-pass type II membrane protein Highly expressed in brown adipose, cardiac and skeletal muscle (at protein level). Uqcc6 deficiency leads to complete loss of mitochondrial respiratory chain complex III, resulting in growth retardation and a mild increase in blood lactate levels and significantly decreased exercise tolerance. The subunits of mitochondrial respiratory chain complex I, II, IV, and V are not affected. Belongs to the UQCC6 family. molecular_function cellular_component extracellular region biological_process uc007gjp.1 uc007gjp.2 uc007gjp.3 uc007gjp.4 
ENSMUST00000079652.7 Sox7 ENSMUST00000079652.7 SRY (sex determining region Y)-box 7 (from RefSeq NM_011446.1) ENSMUST00000079652.1 ENSMUST00000079652.2 ENSMUST00000079652.3 ENSMUST00000079652.4 ENSMUST00000079652.5 ENSMUST00000079652.6 NM_011446 Q3U1W5 Q3U1W5_MOUSE Sox7 uc007uhy.1 uc007uhy.2 uc007uhy.3 endoderm formation DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm negative regulation of cell proliferation positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of transcription, DNA-templated regulation of canonical Wnt signaling pathway uc007uhy.1 uc007uhy.2 uc007uhy.3 
ENSMUST00000079659.12 U2surp ENSMUST00000079659.12 U2 snRNP-associated SURP domain containing, transcript variant 1 (from RefSeq NM_001114977.1) E9QK93 ENSMUST00000079659.1 ENSMUST00000079659.10 ENSMUST00000079659.11 ENSMUST00000079659.2 ENSMUST00000079659.3 ENSMUST00000079659.4 ENSMUST00000079659.5 ENSMUST00000079659.6 ENSMUST00000079659.7 ENSMUST00000079659.8 ENSMUST00000079659.9 NM_001114977 Q6NV83 Q9CSW7 Q9CT00 SR140_MOUSE Sr140 uc009rbb.1 uc009rbb.2 uc009rbb.3 uc009rbb.4 Interacts with ERBB4. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6NV83-1; Sequence=Displayed; Name=2; IsoId=Q6NV83-2; Sequence=VSP_023526; Name=3; IsoId=Q6NV83-3; Sequence=VSP_023525; Belongs to the splicing factor SR family. nucleic acid binding RNA binding nucleus nucleoplasm RNA processing biological_process uc009rbb.1 uc009rbb.2 uc009rbb.3 uc009rbb.4 
ENSMUST00000079660.5 Or7e170 ENSMUST00000079660.5 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFJ1) ENSMUST00000079660.1 ENSMUST00000079660.2 ENSMUST00000079660.3 ENSMUST00000079660.4 Olfr862 Or7e170 Q8VFJ1 Q8VFJ1_MOUSE uc009ohx.1 uc009ohx.2 uc009ohx.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ohx.1 uc009ohx.2 uc009ohx.3 
ENSMUST00000079663.7 Gm2174 ENSMUST00000079663.7 Gm2174 (from geneSymbol) AB347876 ENSMUST00000079663.1 ENSMUST00000079663.2 ENSMUST00000079663.3 ENSMUST00000079663.4 ENSMUST00000079663.5 ENSMUST00000079663.6 F6ZVF2 F6ZVF2_MOUSE Gm2174 uc292ofz.1 uc292ofz.2 molecular_function cellular_component biological_process uc292ofz.1 uc292ofz.2 
ENSMUST00000079681.6 Cyb5d2 ENSMUST00000079681.6 cytochrome b5 domain containing 2 (from RefSeq NM_001024926.3) A0AUN6 Cyb5d2 ENSMUST00000079681.1 ENSMUST00000079681.2 ENSMUST00000079681.3 ENSMUST00000079681.4 ENSMUST00000079681.5 NEUFC_MOUSE NM_001024926 Q0VGS6 Q5SSH8 Q8BHV3 uc007jzi.1 uc007jzi.2 uc007jzi.3 uc007jzi.4 Heme-binding protein which promotes neuronal but not astrocyte differentiation. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SSH8-1; Sequence=Displayed; Name=2; IsoId=Q5SSH8-2; Sequence=VSP_029827; Expressed in various tissues including brain, heart, adrenal gland, and kidney. In the brain, mainly expressed in pyramidal cells around the CA3 region of Ammon horn in hippocampus. Present in brain (at protein level). Abundantly expressed in the developing brain, in subventricular and ventricular zones of the cerebrum, where neural stem cells and neural precursor cells primarily exist. Expression levels gradually increase during brain development, between 14.5 dpc and P49. The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 73 and 106. Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). Belongs to the cytochrome b5 family. MAPR subfamily. Sequence=BAC37998.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=BAE23849.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=BAE25095.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; extracellular region nervous system development heme binding positive regulation of neuron differentiation uc007jzi.1 uc007jzi.2 uc007jzi.3 uc007jzi.4 
ENSMUST00000079691.13 Gss ENSMUST00000079691.13 glutathione synthetase, transcript variant 1 (from RefSeq NM_008180.2) ENSMUST00000079691.1 ENSMUST00000079691.10 ENSMUST00000079691.11 ENSMUST00000079691.12 ENSMUST00000079691.2 ENSMUST00000079691.3 ENSMUST00000079691.4 ENSMUST00000079691.5 ENSMUST00000079691.6 ENSMUST00000079691.7 ENSMUST00000079691.8 ENSMUST00000079691.9 Gss NM_008180 Q541E2 Q541E2_MOUSE uc008nkx.1 uc008nkx.2 uc008nkx.3 Reaction=ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate; Xref=Rhea:RHEA:13557, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:57925, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13558; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. Belongs to the eukaryotic GSH synthase family. nucleotide binding magnesium ion binding glutathione synthase activity ATP binding cytosol glutathione biosynthetic process aging response to xenobiotic stimulus glycine binding ligase activity response to nutrient levels response to tumor necrosis factor peptide binding identical protein binding protein homodimerization activity response to amino acid glutathione binding metal ion binding uc008nkx.1 uc008nkx.2 uc008nkx.3 
ENSMUST00000079692.6 Gpr182 ENSMUST00000079692.6 G protein-coupled receptor 182 (from RefSeq NM_007412.2) ENSMUST00000079692.1 ENSMUST00000079692.2 ENSMUST00000079692.3 ENSMUST00000079692.4 ENSMUST00000079692.5 G3X9R9 G3X9R9_MOUSE Gpr182 NM_007412 uc007hkm.1 uc007hkm.2 uc007hkm.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc007hkm.1 uc007hkm.2 uc007hkm.3 
ENSMUST00000079693.12 Gpatch1 ENSMUST00000079693.12 G patch domain containing 1 (from RefSeq NM_026181.1) ENSMUST00000079693.1 ENSMUST00000079693.10 ENSMUST00000079693.11 ENSMUST00000079693.2 ENSMUST00000079693.3 ENSMUST00000079693.4 ENSMUST00000079693.5 ENSMUST00000079693.6 ENSMUST00000079693.7 ENSMUST00000079693.8 ENSMUST00000079693.9 GPTC1_MOUSE Gpatc1 NM_026181 Q8R0V4 Q9DBM1 uc009gjq.1 uc009gjq.2 uc009gjq.3 Belongs to the GPATCH1 family. molecular_function nucleic acid binding RNA binding nucleus mRNA processing biological_process catalytic step 2 spliceosome uc009gjq.1 uc009gjq.2 uc009gjq.3 
ENSMUST00000079697.10 Mup7 ENSMUST00000079697.10 major urinary protein 7 (from RefSeq NM_001347129.1) CT990633.3-001 ENSMUST00000079697.1 ENSMUST00000079697.2 ENSMUST00000079697.3 ENSMUST00000079697.4 ENSMUST00000079697.5 ENSMUST00000079697.6 ENSMUST00000079697.7 ENSMUST00000079697.8 ENSMUST00000079697.9 Mup1 Mup3 Mup7 NM_001347129 Q58EV3 Q58EV3_MOUSE uc008tai.1 uc008tai.2 uc008tai.3 uc008tai.4 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc008tai.1 uc008tai.2 uc008tai.3 uc008tai.4 
ENSMUST00000079703.11 Nsmce2 ENSMUST00000079703.11 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase, transcript variant 1 (from RefSeq NM_026746.3) ENSMUST00000079703.1 ENSMUST00000079703.10 ENSMUST00000079703.2 ENSMUST00000079703.3 ENSMUST00000079703.4 ENSMUST00000079703.5 ENSMUST00000079703.6 ENSMUST00000079703.7 ENSMUST00000079703.8 ENSMUST00000079703.9 Mms21 NM_026746 NSE2_MOUSE Q8BQ88 Q91VT1 Q9D1D3 uc007vxv.1 uc007vxv.2 uc007vxv.3 uc007vxv.4 E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression. Protein modification; protein sumoylation. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. Nucleus Chromosome, telomere Nucleus, PML body Note=Localizes to PML nuclear bodies in ALT cell lines. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VT1-1; Sequence=Displayed; Name=2; IsoId=Q91VT1-2; Sequence=VSP_022250; Sumoylated, possibly via autosumoylation. Belongs to the NSE2 family. telomere maintenance via recombination double-strand break repair via homologous recombination chromosome, telomeric region ubiquitin-protein transferase activity nucleus chromosome DNA repair DNA recombination cellular response to DNA damage stimulus cell cycle zinc ion binding protein ubiquitination nuclear body PML body transferase activity protein sumoylation SUMO transferase activity Smc5-Smc6 complex positive regulation of maintenance of mitotic sister chromatid cohesion positive regulation of mitotic metaphase/anaphase transition metal ion binding cell division cellular senescence uc007vxv.1 uc007vxv.2 uc007vxv.3 uc007vxv.4 
ENSMUST00000079711.3 Or12e10 ENSMUST00000079711.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AV42) A2AV42 A2AV42_MOUSE ENSMUST00000079711.1 ENSMUST00000079711.2 Olfr1145 Or12e10 uc289xwo.1 uc289xwo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xwo.1 uc289xwo.2 
ENSMUST00000079719.11 Tbx3 ENSMUST00000079719.11 Nucleus (from UniProt Q4VA43) AK157247 ENSMUST00000079719.1 ENSMUST00000079719.10 ENSMUST00000079719.2 ENSMUST00000079719.3 ENSMUST00000079719.4 ENSMUST00000079719.5 ENSMUST00000079719.6 ENSMUST00000079719.7 ENSMUST00000079719.8 ENSMUST00000079719.9 Q4VA43 Q4VA43_MOUSE Tbx3 uc290zax.1 uc290zax.2 Nucleus Lacks conserved residue(s) required for the propagation of feature annotation. DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated uc290zax.1 uc290zax.2 
ENSMUST00000079721.9 En1 ENSMUST00000079721.9 engrailed 1 (from RefSeq NM_010133.3) ENSMUST00000079721.1 ENSMUST00000079721.2 ENSMUST00000079721.3 ENSMUST00000079721.4 ENSMUST00000079721.5 ENSMUST00000079721.6 ENSMUST00000079721.7 ENSMUST00000079721.8 En-1 HME1_MOUSE NM_010133 P09065 Q3USF7 uc007cjm.1 uc007cjm.2 uc007cjm.3 uc007cjm.4 Required for proper formation of the apical ectodermal ridge and correct dorsal-ventral patterning in the limb. Nucleus. Belongs to the engrailed homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development adult locomotory behavior dorsal/ventral pattern formation proximal/distal pattern formation regulation of gene expression membrane RSC complex cerebellum development neuron differentiation embryonic limb morphogenesis midbrain development hindbrain development midbrain-hindbrain boundary development embryonic forelimb morphogenesis social behavior multicellular organism growth drinking behavior pigmentation negative regulation of neuron apoptotic process sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter neuron development limb development motor learning dopaminergic neuron differentiation negative regulation of neuron death embryonic brain development uc007cjm.1 uc007cjm.2 uc007cjm.3 uc007cjm.4 
ENSMUST00000079724.9 Hax1 ENSMUST00000079724.9 HCLS1 associated X-1, transcript variant 1 (from RefSeq NM_011826.4) ENSMUST00000079724.1 ENSMUST00000079724.2 ENSMUST00000079724.3 ENSMUST00000079724.4 ENSMUST00000079724.5 ENSMUST00000079724.6 ENSMUST00000079724.7 ENSMUST00000079724.8 HAX1_MOUSE Hs1bp1 NM_011826 O35387 Q542F8 uc008qaj.1 uc008qaj.2 uc008qaj.3 uc008qaj.4 Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. Interacts with ABCB1, ABCB4 and ABCB11 (By similarity). Directly associates with HCLS1/HS1, through binding to its N-terminal region (By similarity). Interacts with CTTN (PubMed:10760273). Interacts with PKD2(PubMed:10760273). Interacts with GNA13. Interacts with CASP9. Interacts with ITGB6. Interacts with PLN and ATP2A2; these interactions are inhibited by calcium. Interacts with GRB7. Interacts (via C-terminus) with XIAP/BIRC4 (via BIR 2 domain and BIR 3 domain) and this interaction blocks ubiquitination of XIAP/BIRC4. Interacts with TPC2. Interacts with KCNC3 (PubMed:26997484). Interacts with XPO1 (By similarity). Interacts with RNF217 (By similarity). Interacts with UCP3; the interaction is direct and calcium-dependent (PubMed:26915802). O35387; Q8BWG8: Arrb1; NbExp=6; IntAct=EBI-642449, EBI-641778; O35387; Q9JIY5: Htra2; NbExp=3; IntAct=EBI-642449, EBI-2365838; O35387; Q5XJY4: Parl; NbExp=2; IntAct=EBI-642449, EBI-5395457; O35387; P42227: Stat3; NbExp=11; IntAct=EBI-642449, EBI-602878; O35387; Q13563: PKD2; Xeno; NbExp=3; IntAct=EBI-642449, EBI-7813714; Mitochondrion matrix Endoplasmic reticulum Nucleus membrane Cytoplasmic vesicle Cytoplasm, cell cortex Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Sarcoplasmic reticulum Cytoplasm, P-body Cytoplasm Nucleus Note=Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro). Ubiquitous, with highest levels in kidney and liver (at protein level). Mice lacking Hax1 fail to survive longer than 14 weeks, due to a loss of motor coordination and activity, leading to failure to eat and drink. They display extensive apoptosis of neurons in the striatum and cerebellum, and a loss of lymphocytes in spleen, bone marrow and thymus. Belongs to the HAX1 family. P-body protein binding nucleus transcription factor complex cytoplasm mitochondrion mitochondrial outer membrane mitochondrial intermembrane space endoplasmic reticulum plasma membrane cell cortex cell surface receptor signaling pathway positive regulation of phosphatidylinositol 3-kinase signaling actin cytoskeleton membrane apical plasma membrane sarcoplasmic reticulum protein domain specific binding interleukin-1 binding lamellipodium clathrin-coated vesicle regulation of actin filament polymerization positive regulation of granulocyte differentiation cytoplasmic vesicle nuclear membrane positive regulation of peptidyl-serine phosphorylation negative regulation of apoptotic process intracellular membrane-bounded organelle positive regulation of transcription from RNA polymerase II promoter protein N-terminus binding positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein kinase B signaling cellular response to cytokine stimulus positive regulation of actin cytoskeleton reorganization uc008qaj.1 uc008qaj.2 uc008qaj.3 uc008qaj.4 
ENSMUST00000079735.12 Rpl30 ENSMUST00000079735.12 ribosomal protein L30, transcript variant 2 (from RefSeq NM_001163485.2) ENSMUST00000079735.1 ENSMUST00000079735.10 ENSMUST00000079735.11 ENSMUST00000079735.2 ENSMUST00000079735.3 ENSMUST00000079735.4 ENSMUST00000079735.5 ENSMUST00000079735.6 ENSMUST00000079735.7 ENSMUST00000079735.8 ENSMUST00000079735.9 NM_001163485 Q58DZ3 Q58DZ3_MOUSE Rpl30 uc007vlr.1 uc007vlr.2 uc007vlr.3 uc007vlr.4 uc007vlr.5 Belongs to the eukaryotic ribosomal protein eL30 family. cytoplasmic translation RNA binding structural constituent of ribosome nucleus ribosome postsynaptic density cytosolic large ribosomal subunit killing of cells of other organism polysomal ribosome defense response to Gram-negative bacterium uc007vlr.1 uc007vlr.2 uc007vlr.3 uc007vlr.4 uc007vlr.5 
ENSMUST00000079738.10 Ccdc192 ENSMUST00000079738.10 coiled-coil domain containing 192, transcript variant 1 (from RefSeq NM_029290.2) Ccdc192 E9PYL8 E9PYL8_MOUSE ENSMUST00000079738.1 ENSMUST00000079738.2 ENSMUST00000079738.3 ENSMUST00000079738.4 ENSMUST00000079738.5 ENSMUST00000079738.6 ENSMUST00000079738.7 ENSMUST00000079738.8 ENSMUST00000079738.9 NM_029290 uc008ezg.1 uc008ezg.2 uc008ezg.3 uc008ezg.4 molecular_function cellular_component biological_process uc008ezg.1 uc008ezg.2 uc008ezg.3 uc008ezg.4 
ENSMUST00000079749.6 Zfp422 ENSMUST00000079749.6 zinc finger protein 422, transcript variant 1 (from RefSeq NM_026057.3) ENSMUST00000079749.1 ENSMUST00000079749.2 ENSMUST00000079749.3 ENSMUST00000079749.4 ENSMUST00000079749.5 Krox25 Krox26 NM_026057 Q3TF83 Q8VEK7 Q9ERU3 ZNF22_MOUSE Znf22 uc009dkl.1 uc009dkl.2 uc009dkl.3 This gene encodes a putative C2H2 zinc finger transcription factor that may play a role in tooth development. A pseudogene related to this gene is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation. Nucleus Expressed predominantly in developing craniofacial bones and dental organs, and in molar tooth germs of postnatal animals. Also detected in embryonic heart, liver, thymus, kidney, brain, lung, muscle and calvaria. In the adult, highly expressed in lung, kidney, bone and incisors. In the embryo, expression is detected from day 7 with highest levels between days 11 and 15. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAG12466.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated odontogenesis metal ion binding uc009dkl.1 uc009dkl.2 uc009dkl.3 
ENSMUST00000079754.11 Cpeb3 ENSMUST00000079754.11 cytoplasmic polyadenylation element binding protein 3, transcript variant 2 (from RefSeq NM_198300.3) A0A0R4J102 A0A0R4J102_MOUSE Cpeb3 ENSMUST00000079754.1 ENSMUST00000079754.10 ENSMUST00000079754.2 ENSMUST00000079754.3 ENSMUST00000079754.4 ENSMUST00000079754.5 ENSMUST00000079754.6 ENSMUST00000079754.7 ENSMUST00000079754.8 ENSMUST00000079754.9 NM_198300 uc008hib.1 uc008hib.2 uc008hib.3 uc008hib.4 Belongs to the RRM CPEB family. negative regulation of transcription from RNA polymerase II promoter nucleic acid binding RNA binding mRNA 3'-UTR binding nucleus cytoplasm translation regulation of translation translation factor activity, RNA binding negative regulation of translation CCR4-NOT complex dendrite neuron projection translation regulator activity positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 3'-UTR-mediated mRNA destabilization cellular response to amino acid stimulus postsynapse positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay uc008hib.1 uc008hib.2 uc008hib.3 uc008hib.4 
ENSMUST00000079755.5 Gm5148 ENSMUST00000079755.5 predicted gene 5148 (from RefSeq NM_198657.2) EG381438 ENSMUST00000079755.1 ENSMUST00000079755.2 ENSMUST00000079755.3 ENSMUST00000079755.4 Gm5148 NM_198657 Q8BGG2 Q8BGG2_MOUSE uc008paz.1 uc008paz.2 uc008paz.3 molecular_function cellular_component biological_process uc008paz.1 uc008paz.2 uc008paz.3 
ENSMUST00000079759.6 Gm5591 ENSMUST00000079759.6 predicted gene 5591 (from RefSeq NM_001013810.2) EG434171 ENSMUST00000079759.1 ENSMUST00000079759.2 ENSMUST00000079759.3 ENSMUST00000079759.4 ENSMUST00000079759.5 Gm5591 NM_001013810 Q8CDK1 Q8CDK1_MOUSE uc009gkx.1 uc009gkx.2 molecular_function cellular_component biological_process uc009gkx.1 uc009gkx.2 
ENSMUST00000079764.14 Wdr83os ENSMUST00000079764.14 WD repeat domain 83 opposite strand (from RefSeq NM_001001493.2) ASTER_MOUSE ENSMUST00000079764.1 ENSMUST00000079764.10 ENSMUST00000079764.11 ENSMUST00000079764.12 ENSMUST00000079764.13 ENSMUST00000079764.2 ENSMUST00000079764.3 ENSMUST00000079764.4 ENSMUST00000079764.5 ENSMUST00000079764.6 ENSMUST00000079764.7 ENSMUST00000079764.8 ENSMUST00000079764.9 NM_001001493 Q6ZWX0 Wdr83os uc009mpj.1 uc009mpj.2 uc009mpj.3 Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein. Within the PAT subcomplex, WDR83OS/Asterix binds to and redirects the substrate to a location behind the SEC61 complex (By similarity). Component of the PAT complex, composed of WDR83OS/Asterix and CCDC47. The PAT complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex. Endoplasmic reticulum membrane ; Multi-pass membrane protein Expressed in the liver. Belongs to the Asterix family. molecular_function cellular_component biological_process membrane integral component of membrane uc009mpj.1 uc009mpj.2 uc009mpj.3 
ENSMUST00000079772.4 Tnfrsf11b ENSMUST00000079772.4 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin), transcript variant 1 (from RefSeq NM_008764.4) ENSMUST00000079772.1 ENSMUST00000079772.2 ENSMUST00000079772.3 NM_008764 Q3UK97 Q3UK97_MOUSE Tnfrsf11b uc007vrk.1 uc007vrk.2 Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Homodimer. Secreted Lacks conserved residue(s) required for the propagation of feature annotation. extracellular space apoptotic process signal transduction response to nutrient response to inorganic substance response to magnesium ion negative regulation of odontogenesis of dentin-containing tooth response to drug response to estrogen negative regulation of bone resorption response to arsenic-containing substance uc007vrk.1 uc007vrk.2 
ENSMUST00000079784.12 Myl3 ENSMUST00000079784.12 myosin, light polypeptide 3, transcript variant 1 (from RefSeq NM_010859.3) ENSMUST00000079784.1 ENSMUST00000079784.10 ENSMUST00000079784.11 ENSMUST00000079784.2 ENSMUST00000079784.3 ENSMUST00000079784.4 ENSMUST00000079784.5 ENSMUST00000079784.6 ENSMUST00000079784.7 ENSMUST00000079784.8 ENSMUST00000079784.9 MYL3_MOUSE Mlc1v Myl3 Mylc NM_010859 P09542 Q3UIF4 Q9CQZ2 uc009rur.1 uc009rur.2 uc009rur.3 Regulatory light chain of myosin. Does not bind calcium. Myosin is a hexamer of 2 heavy chains and 4 light chains. N-terminus is methylated by METTL11A/NTM1. regulation of the force of heart contraction motor activity actin monomer binding calcium ion binding regulation of striated muscle contraction skeletal muscle tissue development myosin complex A band I band ventricular cardiac muscle tissue morphogenesis cardiac muscle contraction uc009rur.1 uc009rur.2 uc009rur.3 
ENSMUST00000079788.7 Mkx ENSMUST00000079788.7 mohawk homeobox (from RefSeq NM_177595.4) B2RQ30 B2RQ30_MOUSE ENSMUST00000079788.1 ENSMUST00000079788.2 ENSMUST00000079788.3 ENSMUST00000079788.4 ENSMUST00000079788.5 ENSMUST00000079788.6 Mkx NM_177595 uc008dzp.1 uc008dzp.2 uc008dzp.3 uc008dzp.4 Nucleus Belongs to the TALE/IRO homeobox family. DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc008dzp.1 uc008dzp.2 uc008dzp.3 uc008dzp.4 
ENSMUST00000079791.11 Pcyt1a ENSMUST00000079791.11 phosphate cytidylyltransferase 1, choline, alpha isoform, transcript variant 2 (from RefSeq NM_009981.4) Ctpct ENSMUST00000079791.1 ENSMUST00000079791.10 ENSMUST00000079791.2 ENSMUST00000079791.3 ENSMUST00000079791.4 ENSMUST00000079791.5 ENSMUST00000079791.6 ENSMUST00000079791.7 ENSMUST00000079791.8 ENSMUST00000079791.9 NM_009981 P49586 PCY1A_MOUSE Pcyt1 Q542W4 uc007yyw.1 uc007yyw.2 uc007yyw.3 uc007yyw.4 Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. Reaction=CTP + H(+) + phosphocholine = CDP-choline + diphosphate; Xref=Rhea:RHEA:18997, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:58779, ChEBI:CHEBI:295975; EC=2.7.7.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18998; Evidence=; By phosphorylation. Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2. Homodimer. Cytoplasm, cytosol Membrane ; Peripheral membrane protein Endoplasmic reticulum Nucleus Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form. Brain and liver (at protein level) (PubMed:12842190). Also found in heart, kidney, spleen, lung, skeletal muscle, ovary and testis (PubMed:12842190). The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation (By similarity). Monoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation. Belongs to the cytidylyltransferase family. catalytic activity choline-phosphate cytidylyltransferase activity protein binding calmodulin binding nuclear envelope cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane lipid metabolic process phosphatidylcholine biosynthetic process CDP-choline pathway lipid binding phospholipid biosynthetic process biosynthetic process membrane transferase activity nucleotidyltransferase activity phosphatidylcholine binding glycogen granule protein homodimerization activity uc007yyw.1 uc007yyw.2 uc007yyw.3 uc007yyw.4 
ENSMUST00000079793.7 Pth ENSMUST00000079793.7 parathyroid hormone (from RefSeq NM_020623.2) ENSMUST00000079793.1 ENSMUST00000079793.2 ENSMUST00000079793.3 ENSMUST00000079793.4 ENSMUST00000079793.5 ENSMUST00000079793.6 NM_020623 Pth Q9Z0L6 Q9Z0L6_MOUSE uc009jhm.1 uc009jhm.2 uc009jhm.3 PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Interacts with PTH1R (via N-terminal extracellular domain). Secreted Belongs to the parathyroid hormone family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding hormone activity extracellular region extracellular space cell cellular calcium ion homeostasis adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of phospholipase C activity Rho protein signal transduction cell-cell signaling positive regulation of signal transduction response to lead ion regulation of gene expression magnesium ion homeostasis positive regulation of bone mineralization response to nutrient levels parathyroid hormone receptor binding type 1 parathyroid hormone receptor binding negative regulation of chondrocyte differentiation response to vitamin D cellular macromolecule biosynthetic process response to drug response to ethanol positive regulation of glycogen biosynthetic process positive regulation of ossification positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import response to cadmium ion protein N-terminus binding receptor agonist activity homeostasis of number of cells within a tissue peptide hormone receptor binding negative regulation of calcium ion transport phosphate ion homeostasis calcium ion homeostasis positive regulation of inositol phosphate biosynthetic process response to parathyroid hormone response to fibroblast growth factor positive regulation of cell proliferation in bone marrow negative regulation of apoptotic process in bone marrow positive regulation of osteoclast proliferation negative regulation of bone mineralization involved in bone maturation uc009jhm.1 uc009jhm.2 uc009jhm.3 
ENSMUST00000079797.13 Gm10058 ENSMUST00000079797.13 predicted gene 10058 (from RefSeq NM_001109969.2) ENSMUST00000079797.1 ENSMUST00000079797.10 ENSMUST00000079797.11 ENSMUST00000079797.12 ENSMUST00000079797.2 ENSMUST00000079797.3 ENSMUST00000079797.4 ENSMUST00000079797.5 ENSMUST00000079797.6 ENSMUST00000079797.7 ENSMUST00000079797.8 ENSMUST00000079797.9 Gm10058 Gm10096 Gm10147 Gm10230 Gm10486 Gm10487 Gm14632 Gm14819 Gm4836 NM_001109969 Q62478 Q62478_MOUSE XMR uc009svt.1 uc009svt.2 uc009svt.3 uc009svt.4 uc009svt.5 uc009svt.6 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function nucleus spermatogenesis spermatid development meiotic cell cycle uc009svt.1 uc009svt.2 uc009svt.3 uc009svt.4 uc009svt.5 uc009svt.6 
ENSMUST00000079804.2 Or8b41 ENSMUST00000079804.2 olfactory receptor family 8 subfamily B member 41 (from RefSeq NM_146481.2) ENSMUST00000079804.1 NM_146481 Olfr890 Or8b41 Q7TRD9 Q7TRD9_MOUSE uc009ovy.1 uc009ovy.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ovy.1 uc009ovy.2 
ENSMUST00000079811.13 Ugt2a2 ENSMUST00000079811.13 UDP glucuronosyltransferase 2 family, polypeptide A2 (from RefSeq NM_001024148.1) ENSMUST00000079811.1 ENSMUST00000079811.10 ENSMUST00000079811.11 ENSMUST00000079811.12 ENSMUST00000079811.2 ENSMUST00000079811.3 ENSMUST00000079811.4 ENSMUST00000079811.5 ENSMUST00000079811.6 ENSMUST00000079811.7 ENSMUST00000079811.8 ENSMUST00000079811.9 NM_001024148 Q6PDD0 UD2A2_MOUSE Ugt2a2 uc008xyj.1 uc008xyj.2 uc008xyj.3 UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormone estradiol. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth. Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21033; Evidence=; Reaction=17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52868, ChEBI:CHEBI:15378, ChEBI:CHEBI:17160, ChEBI:CHEBI:57529, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52869; Evidence=; Reaction=17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52460, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136641; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52461; Evidence=; Reaction=chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52940, ChEBI:CHEBI:36234, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136899; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52941; Evidence=; Reaction=lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O- (beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52952, ChEBI:CHEBI:29744, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136902; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52953; Evidence=; Reaction=deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O- (beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52948, ChEBI:CHEBI:23614, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136901; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52949; Evidence=; Reaction=hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta- D-glucuronate) + UDP; Xref=Rhea:RHEA:52960, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:133661, ChEBI:CHEBI:136904; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52961; Evidence=; Reaction=hyodeoxycholate + UDP-alpha-D-glucuronate = H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52964, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:58875, ChEBI:CHEBI:136905; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52965; Evidence=; Membrane ; Single- pass type I membrane protein UGT2A2 isoform is part of the UGT2A complex locus which displays alternative use of promoters and exons. The locus is defined by 2 alternative promoters resulting in 2 fonctionally active polypeptides UGT2A1 and UGT2A2. Alternative splicing of exons results in additional isoforms for each protein class. Belongs to the UDP-glycosyltransferase family. UDP-glycosyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups intracellular membrane-bounded organelle cellular glucuronidation uc008xyj.1 uc008xyj.2 uc008xyj.3 
ENSMUST00000079812.8 Notch2 ENSMUST00000079812.8 notch 2 (from RefSeq NM_010928.2) ENSMUST00000079812.1 ENSMUST00000079812.2 ENSMUST00000079812.3 ENSMUST00000079812.4 ENSMUST00000079812.5 ENSMUST00000079812.6 ENSMUST00000079812.7 G5E8J0 NM_010928 NOTC2_MOUSE Notch2 O35516 Q06008 Q60941 uc008qpo.1 uc008qpo.2 uc008qpo.3 Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (PubMed:10393120). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:10393120, PubMed:18710934). Affects the implementation of differentiation, proliferation and apoptotic programs (PubMed:10393120, PubMed:18710934). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation (By similarity). In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:18710934). Positively regulates self-renewal of liver cancer cells (By similarity). Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH2. Interacts with RELA/p65. Interacts with HIF1AN. Interacts (via ANK repeats) with TCIM, the interaction inhibits the nuclear translocation of NOTCH2 N2ICD (By similarity). Interacts with CUL1, RBX1, SKP1 and FBXW7 that are SCF(FBXW7) E3 ubiquitin-protein ligase complex components. Interacts with MINAR1; this interaction increases MINAR1 stability and function (By similarity). Interacts with MDK; this interaction mediates a nuclear accumulation of NOTCH2 and therefore activation of NOTCH2 signaling leading to interaction between HES1 and STAT3 (By similarity). Interacts with MINAR2 (By similarity). [Notch 2 extracellular truncation]: Cell membrane ; Single-pass type I membrane protein [Notch 2 intracellular domain]: Nucleus Cytoplasm Note=Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by TCIM. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O35516-1; Sequence=Displayed; Name=2; IsoId=O35516-2; Sequence=VSP_001405; Expressed in the brain, liver, kidney, neuroepithelia, somites, optic vesicles and branchial arches, but not heart. Expressed in the embryonic ventricular zone, the postnatal ependymal cells, and the choroid plexus throughout embryonic and postnatal development. Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans- Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form (PubMed:11459941, PubMed:11518718). Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC) (PubMed:11459941, PubMed:11518718). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane- associated intermediate fragment called notch extracellular truncation (NEXT) (By similarity). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (PubMed:11459941, PubMed:11518718). Hydroxylated by HIF1AN. Can be either O-glucosylated or O-xylosylated at Ser-613 by POGLUT1. Phosphorylated by GSK3. GSK3-mediated phosphorylation is necessary for NOTCH2 recognition by FBXW7, ubiquitination and degradation via the ubiquitin proteasome pathway. Belongs to the NOTCH family. Sequence=BAA22094.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter in utero embryonic development cell fate determination liver development placenta development heart looping morphogenesis of an epithelial sheet marginal zone B cell differentiation inflammatory response to antigenic stimulus pulmonary valve morphogenesis calcium ion binding protein binding extracellular region nucleus nucleoplasm cytoplasm cytosol plasma membrane integral component of plasma membrane cilium regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter humoral immune response cell cycle arrest Notch signaling pathway multicellular organism development determination of left/right symmetry positive regulation of cell proliferation animal organ morphogenesis cell surface negative regulation of gene expression positive regulation of keratinocyte proliferation membrane integral component of membrane enzyme binding cell differentiation embryonic limb morphogenesis positive regulation of BMP signaling pathway multicellular organism growth intrahepatic bile duct development signaling receptor activity wound healing defense response to bacterium myeloid dendritic cell differentiation positive regulation of apoptotic process receptor complex positive regulation of osteoclast differentiation negative regulation of growth rate positive regulation of Ras protein signal transduction bone remodeling regulation of developmental process NF-kappaB binding atrial septum morphogenesis placenta blood vessel development ciliary body morphogenesis positive regulation of ERK1 and ERK2 cascade left/right axis specification proximal tubule development glomerular visceral epithelial cell development glomerular capillary formation hepatocyte proliferation liver morphogenesis interleukin-4 secretion cholangiocyte proliferation regulation of actin cytoskeleton reorganization regulation of osteoclast development uc008qpo.1 uc008qpo.2 uc008qpo.3 
ENSMUST00000079817.8 Stk24 ENSMUST00000079817.8 serine/threonine kinase 24 (from RefSeq NM_145465.2) ENSMUST00000079817.1 ENSMUST00000079817.2 ENSMUST00000079817.3 ENSMUST00000079817.4 ENSMUST00000079817.5 ENSMUST00000079817.6 ENSMUST00000079817.7 Mst3 NM_145465 Q99KH8 STK24_MOUSE Stk3 uc007vac.1 uc007vac.2 uc007vac.3 Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. Acts as a key regulator of axon regeneration in the optic nerve and radial nerve (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Monomer. Interacts with CTTNBP2NL. Interacts with RIPOR1 (via C-terminus); this interaction occurs in a PDCD10-dependent and Rho- independent manner. Interacts with PDCD10; this interaction is required for the association of STK24 with RIPOR1. Cytoplasm Nucleus Membrane Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane (By similarity). Proteolytically processed by caspases during apoptosis. Proteolytic cleavage results in kinase activation, nuclear translocation of the truncated form (MST3/N) and the induction of apoptosis (By similarity). Oxidative stress induces phosphorylation. Activated by autophosphorylation at Thr-178 and phosphorylation at this site is essential for its function. Manganese, magnesium and cobalt-dependent autophosphorylation is mainly on threonine residues while zinc- dependent autophosphorylation is on both serine and threonine residues (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Golgi membrane nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleolus cytoplasm cytosol protein phosphorylation apoptotic process intrinsic apoptotic signaling pathway in response to oxidative stress cellular response to starvation membrane kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation negative regulation of cell migration activation of protein kinase activity response to hydrogen peroxide protein autophosphorylation metal ion binding regulation of axon regeneration positive regulation of axon regeneration execution phase of apoptosis uc007vac.1 uc007vac.2 uc007vac.3 
ENSMUST00000079824.6 Gpr84 ENSMUST00000079824.6 G protein-coupled receptor 84, transcript variant 1 (from RefSeq NM_030720.3) A0A0R4J100 A0A0R4J100_MOUSE ENSMUST00000079824.1 ENSMUST00000079824.2 ENSMUST00000079824.3 ENSMUST00000079824.4 ENSMUST00000079824.5 Gpr84 NM_030720 uc007xxy.1 uc007xxy.2 uc007xxy.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity G-protein coupled receptor signaling pathway membrane integral component of membrane uc007xxy.1 uc007xxy.2 uc007xxy.3 
ENSMUST00000079828.7 Ntrk2 ENSMUST00000079828.7 neurotrophic tyrosine kinase, receptor, type 2, transcript variant 1 (from RefSeq NM_001025074.3) ENSMUST00000079828.1 ENSMUST00000079828.2 ENSMUST00000079828.3 ENSMUST00000079828.4 ENSMUST00000079828.5 ENSMUST00000079828.6 NM_001025074 NTRK2_MOUSE Ntrk2 P15209 Q3TUF9 Q80WU0 Q91XJ9 Trkb uc007quj.1 uc007quj.2 uc007quj.3 Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. Isoform GP95-TRKB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence= The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms (By similarity). The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation. Interacts with SH2B1 and SH2B2. Interacts with NGFR; may regulate the ligand specificity of the receptor (By similarity). Interacts with SORCS2; this interaction is important for normal targeting to post-synaptic densities in response to high-frequency stimulation (PubMed:27457814). Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway (By similarity). Interacts with APPL1 (PubMed:21849472). Interacts with MAPK8IP3/JIP3 and KLC1; interaction with KLC1 is mediated by MAPK8IP3/JIP3 (By similarity). Interacts with SORL1; this interaction facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling (PubMed:23977241). Interacts with SLITRK2 (By similarity). P15209; Q62108: Dlg4; NbExp=4; IntAct=EBI-309647, EBI-300895; P15209; Q99LI8: Hgs; NbExp=2; IntAct=EBI-309647, EBI-2119135; P15209; Q8K4V6: Pirb; NbExp=4; IntAct=EBI-309647, EBI-8602514; P15209; P35235: Ptpn11; NbExp=2; IntAct=EBI-309647, EBI-397236; P15209; Q6PHU5: Sort1; NbExp=3; IntAct=EBI-309647, EBI-6985663; Cell membrane ; Single-pass type I membrane protein Endosome membrane ; Single-pass type I membrane protein Early endosome membrane Cell projection, axon Cell projection, dendrite Cytoplasm, perinuclear region Postsynaptic density Note=Internalized to endosomes upon ligand-binding. Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=GP145-TRKB; Synonyms=L3, TrkBTK+, TRKB-FL; IsoId=P15209-1; Sequence=Displayed; Name=GP95-TRKB; Synonyms=TRKB-T1, TrkBTK-; IsoId=P15209-2; Sequence=VSP_002908, VSP_002909; Name=L1; IsoId=P15209-3; Sequence=VSP_002907; Name=L10; IsoId=P15209-4; Sequence=VSP_002905, VSP_002906; Expressed in the brain, in neurons (at protein level) (PubMed:23977241). Detected in hippocampus (at protein level) (PubMed:27457814). Widely expressed in the central and peripheral nervous system. The different forms are differentially expressed in various cell types. Isoform GP95-TRKB is specifically expressed in glial cells. Expression oscillates in a circadian manner in the liver. Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors (PubMed:27457814). Some isoforms are not phosphorylated (By similarity). Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor. Mice lacking isoform GP145-TRKB, the catalytic isoform, do not display feeding activity and die at P1. This is associated neuronal deficiencies in the central and the peripheral nervous systems. [Isoform GP95-TRKB]: Non-catalytic isoform. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. nucleotide binding vasculogenesis neuron migration protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity neurotrophin receptor activity protein binding ATP binding cytoplasm endosome early endosome rough endoplasmic reticulum cytosol plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development neuromuscular junction development learning long-term memory circadian rhythm feeding behavior positive regulation of cell proliferation cell surface endosome membrane positive regulation of gene expression positive regulation of neuron projection development glutamate secretion positive regulation of phosphatidylinositol 3-kinase signaling postsynaptic density membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation regulation of metabolic process neuronal action potential propagation central nervous system neuron development cerebral cortex development myelination in peripheral nervous system cell junction cell differentiation neuron differentiation axon dendrite growth cone receptor tyrosine kinase binding brain-derived neurotrophic factor receptor signaling pathway early endosome membrane positive regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source neurotrophin signaling pathway mechanoreceptor differentiation protein homodimerization activity cell projection neuronal cell body regulation of GTPase activity neurotrophin binding terminal bouton dendritic spine perikaryon receptor complex regulation of MAPK cascade positive regulation of MAPK cascade negative regulation of neuron apoptotic process axon terminus synapse postsynaptic membrane retinal rod cell development protein autophosphorylation regulation of neurotransmitter secretion brain-derived neurotrophic factor binding perinuclear region of cytoplasm oligodendrocyte differentiation presynaptic active zone peripheral nervous system neuron development positive regulation of axonogenesis regulation of dendrite development regulation of protein kinase B signaling positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic retina development in camera-type eye excitatory synapse brain-derived neurotrophic factor-activated receptor activity long-term synaptic potentiation cellular response to amino acid stimulus postsynapse glutamatergic synapse trans-synaptic signaling by neuropeptide, modulating synaptic transmission cellular response to nerve growth factor stimulus cellular response to brain-derived neurotrophic factor stimulus positive regulation of glucocorticoid receptor signaling pathway negative regulation of anoikis positive regulation of ERK1 and ERK2 cascade uc007quj.1 uc007quj.2 uc007quj.3 
ENSMUST00000079833.6 Hsf2 ENSMUST00000079833.6 heat shock factor 2 (from RefSeq NM_008297.3) ENSMUST00000079833.1 ENSMUST00000079833.2 ENSMUST00000079833.3 ENSMUST00000079833.4 ENSMUST00000079833.5 HSF2_MOUSE NM_008297 P38533 Q64157 Q8VEJ0 Q9Z2L8 uc007fck.1 uc007fck.2 uc007fck.3 uc007fck.4 DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. HSF2 is expressed in a form that binds DNA constitutively but loses DNA binding by incubation at greater than 41 degrees C. DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer. Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation. Event=Alternative splicing; Named isoforms=2; Name=Alpha; IsoId=P38533-1; Sequence=Displayed; Name=Beta; IsoId=P38533-2; Sequence=VSP_002417; Isoform alpha is expressed predominantly in testis while isoform beta is expressed predominantly in heart and brain. In the 7-day-old testis, isoform beta is expressed at significantly higher levels than isoform alpha. As development proceeds, the levels of isoform alpha gradually increase so that it is the predominant isoform in mature testes. Belongs to the HSF family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter spermatogenesis cellular response to heat identical protein binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter in response to heat stress uc007fck.1 uc007fck.2 uc007fck.3 uc007fck.4 
ENSMUST00000079855.11 Gm8369 ENSMUST00000079855.11 predicted gene 8369 (from RefSeq NM_001164202.1) E9PZI3 E9PZI3_MOUSE ENSMUST00000079855.1 ENSMUST00000079855.10 ENSMUST00000079855.2 ENSMUST00000079855.3 ENSMUST00000079855.4 ENSMUST00000079855.5 ENSMUST00000079855.6 ENSMUST00000079855.7 ENSMUST00000079855.8 ENSMUST00000079855.9 Gm8369 NM_001164202 uc012bix.1 uc012bix.2 molecular_function cellular_component biological_process membrane integral component of membrane uc012bix.1 uc012bix.2 
ENSMUST00000079859.7 Klk1b27 ENSMUST00000079859.7 kallikrein 1-related peptidase b27 (from RefSeq NM_020268.3) A2RSF8 ENSMUST00000079859.1 ENSMUST00000079859.2 ENSMUST00000079859.3 ENSMUST00000079859.4 ENSMUST00000079859.5 ENSMUST00000079859.6 K1B27_MOUSE Klk-27 Klk27 NM_020268 Q9JM71 uc009gog.1 uc009gog.2 uc009gog.3 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AB039275.1, BC132090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Serine protease with chymotrypsin-like cleavage specificity. Shows activity towards casein, gelatin, IGFBP3 and fibronectin but not towards laminin or collagens I and IV. Does not hydrolyze kininogin to release Lys-bradykinin. Strongly inhibited by protease inhibitors diisopropyl fluorophosphate, phenylmethanesulfonyl fluoride and SBTI. Expressed in testis and submaxillary gland. Not expressed in heart, brain, spleen, lung, liver, muscle, kidney and ovary. In the testis, expression localized specifically to Leydig cells in the interstitial tissues. Detectable in testis 4 weeks after birth, becoming more prominent thereafter. Belongs to the peptidase S1 family. Kallikrein subfamily. regulation of systemic arterial blood pressure endopeptidase activity serine-type endopeptidase activity cellular_component extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides secretory granule zymogen activation macromolecular complex uc009gog.1 uc009gog.2 uc009gog.3 
ENSMUST00000079865.5 Or5p67 ENSMUST00000079865.5 olfactory receptor family 5 subfamily P member 67 (from RefSeq NM_146497.1) ENSMUST00000079865.1 ENSMUST00000079865.2 ENSMUST00000079865.3 ENSMUST00000079865.4 Mor204-18 NM_146497 O5P67_MOUSE Olfr492 Or5p67 Q8VFD1 uc009jcg.1 uc009jcg.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jcg.1 uc009jcg.2 
ENSMUST00000079867.6 Magea3 ENSMUST00000079867.6 MAGE family member A3 (from RefSeq NM_020017.2) ENSMUST00000079867.1 ENSMUST00000079867.2 ENSMUST00000079867.3 ENSMUST00000079867.4 ENSMUST00000079867.5 Magea3 NM_020017 Q6T340 Q6T340_MOUSE uc009urk.1 uc009urk.2 uc009urk.3 uc009urk.4 molecular_function cellular_component biological_process uc009urk.1 uc009urk.2 uc009urk.3 uc009urk.4 
ENSMUST00000079869.13 Znrf2 ENSMUST00000079869.13 zinc and ring finger 2 (from RefSeq NM_199143.2) ENSMUST00000079869.1 ENSMUST00000079869.10 ENSMUST00000079869.11 ENSMUST00000079869.12 ENSMUST00000079869.2 ENSMUST00000079869.3 ENSMUST00000079869.4 ENSMUST00000079869.5 ENSMUST00000079869.6 ENSMUST00000079869.7 ENSMUST00000079869.8 ENSMUST00000079869.9 NM_199143 Q71FD5 ZNRF2_MOUSE uc009cae.1 uc009cae.2 uc009cae.3 uc009cae.4 E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases. In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self- regulating feedback mechanism. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with UBE2N. Interacts with ZNRF1. Interacts (when phosphorylated) with YWHAE. Endosome membrane ; Peripheral membrane protein Lysosome membrane ; Peripheral membrane protein Presynaptic cell membrane ; Peripheral membrane protein Cytoplasm Expressed primarily in the nervous system. Expression is more intense in the granular cell layer of hippocampus, Purkinje cell layer of the cerebellum and the granular cell layer of the olfactory bulb. Detected in sensory neurons but not expressed in sympatic or enteric neurons. Expressed in testis, adipose tissue, columnar epithelial cells of the gut. The RING-type zinc finger domain is required for E3 ligase activity. Phosphorylated; leading to binding to YWHAE. Phosphorylated by MTOR at Ser-147 and dephosphorylated by PP6C. Ser-147 phosphorylation stimulates vesicle-to-cytosol translocation. cytoplasm lysosome lysosomal membrane endosome plasma membrane endosome membrane membrane protein ubiquitination transferase activity cell junction cytoplasmic vesicle membrane macromolecular complex presynaptic membrane synapse metal ion binding ubiquitin protein ligase activity uc009cae.1 uc009cae.2 uc009cae.3 uc009cae.4 
ENSMUST00000079881.11 Zfp398 ENSMUST00000079881.11 zinc finger protein 398, transcript variant 1 (from RefSeq NM_027477.3) ENSMUST00000079881.1 ENSMUST00000079881.10 ENSMUST00000079881.2 ENSMUST00000079881.3 ENSMUST00000079881.4 ENSMUST00000079881.5 ENSMUST00000079881.6 ENSMUST00000079881.7 ENSMUST00000079881.8 ENSMUST00000079881.9 NM_027477 Q8BV16 Q8BV16_MOUSE Zfp398 uc009bti.1 uc009bti.2 uc009bti.3 uc009bti.4 molecular_function nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc009bti.1 uc009bti.2 uc009bti.3 uc009bti.4 
ENSMUST00000079883.12 Scamp4 ENSMUST00000079883.12 secretory carrier membrane protein 4 (from RefSeq NM_019575.4) ENSMUST00000079883.1 ENSMUST00000079883.10 ENSMUST00000079883.11 ENSMUST00000079883.2 ENSMUST00000079883.3 ENSMUST00000079883.4 ENSMUST00000079883.5 ENSMUST00000079883.6 ENSMUST00000079883.7 ENSMUST00000079883.8 ENSMUST00000079883.9 NM_019575 Q9JKV5 SCAM4_MOUSE uc007gdy.1 uc007gdy.2 Probably involved in membrane protein trafficking. Membrane; Multi-pass membrane protein. Belongs to the SCAMP family. Golgi membrane molecular_function Golgi apparatus protein transport membrane integral component of membrane transport vesicle trans-Golgi network membrane recycling endosome membrane uc007gdy.1 uc007gdy.2 
ENSMUST00000079891.4 Or2aj6 ENSMUST00000079891.4 olfactory receptor family 2 subfamily AJ member 6 (from RefSeq NM_146958.2) ENSMUST00000079891.1 ENSMUST00000079891.2 ENSMUST00000079891.3 G5E8J1 G5E8J1_MOUSE NM_146958 Olfr169 Olfr171 Or2aj6 uc007ypa.1 uc007ypa.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007ypa.1 uc007ypa.2 
ENSMUST00000079945.11 Phex ENSMUST00000079945.11 phosphate regulating endopeptidase homolog, X-linked (from RefSeq NM_011077.2) ENSMUST00000079945.1 ENSMUST00000079945.10 ENSMUST00000079945.2 ENSMUST00000079945.3 ENSMUST00000079945.4 ENSMUST00000079945.5 ENSMUST00000079945.6 ENSMUST00000079945.7 ENSMUST00000079945.8 ENSMUST00000079945.9 NM_011077 Phex Q3TYM9 Q3TYM9_MOUSE uc009ury.1 uc009ury.2 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Membrane ; Single- pass type II membrane protein metalloendopeptidase activity proteolysis metallopeptidase activity membrane integral component of membrane lung development response to vitamin D bone development response to growth hormone cellular response to vitamin D cellular response to parathyroid hormone stimulus response to sodium phosphate response to insulin-like growth factor stimulus uc009ury.1 uc009ury.2 
ENSMUST00000079949.13 Ewsr1 ENSMUST00000079949.13 Ewing sarcoma breakpoint region 1, transcript variant 2 (from RefSeq NM_007968.4) ENSMUST00000079949.1 ENSMUST00000079949.10 ENSMUST00000079949.11 ENSMUST00000079949.12 ENSMUST00000079949.2 ENSMUST00000079949.3 ENSMUST00000079949.4 ENSMUST00000079949.5 ENSMUST00000079949.6 ENSMUST00000079949.7 ENSMUST00000079949.8 ENSMUST00000079949.9 EWS_MOUSE Ews Ewsh NM_007968 Q61545 Q9D2P0 uc007hvw.1 uc007hvw.2 uc007hvw.3 uc007hvw.4 Might function as a transcriptional repressor. Binds RNA, POLR2C, SF1 and calmodulin. Interacts with PTK2B and TDRD3 (By similarity). Forms a complex with REC8, PRDM9, SYCP3 and SYCP1; complex formation is dependent of phosphorylated form of REC8 and requires PRDM9 bound to hotspot DNA; EWSR1 joins PRDM9 with the chromosomal axis through REC8 (PubMed:27932493). Q61545; P20263: Pou5f1; NbExp=13; IntAct=EBI-1606991, EBI-1606219; Q61545; Q64012: Raly; NbExp=2; IntAct=EBI-1606991, EBI-6878379; Q61545; Q8C7B8: Zswim4; NbExp=2; IntAct=EBI-1606991, EBI-26673088; Nucleus Cytoplasm Cell membrane Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation. Phosphorylated; calmodulin-binding inhibits phosphorylation of Ser-266. Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8 (By similarity). Binds calmodulin in the presence, but not in the absence, of calcium ion. Belongs to the RRM TET family. nucleic acid binding RNA binding protein binding calmodulin binding nucleus nucleolus cytoplasm plasma membrane regulation of transcription, DNA-templated membrane identical protein binding metal ion binding uc007hvw.1 uc007hvw.2 uc007hvw.3 uc007hvw.4 
ENSMUST00000079952.4 H2al1o ENSMUST00000079952.4 H2A histone family member L1O (from RefSeq NM_001085517.2) ENSMUST00000079952.1 ENSMUST00000079952.2 ENSMUST00000079952.3 Gm5132 H2al1o L7MU04 L7MU04_MOUSE NM_001085517 uc009spx.1 uc009spx.2 uc009spx.3 uc009spx.4 The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc009spx.1 uc009spx.2 uc009spx.3 uc009spx.4 
ENSMUST00000079955.6 Or5k8 ENSMUST00000079955.6 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A140T8K4) A0A140T8K4 A0A140T8K4_MOUSE ENSMUST00000079955.1 ENSMUST00000079955.2 ENSMUST00000079955.3 ENSMUST00000079955.4 ENSMUST00000079955.5 Olfr175 Olfr175-ps1 Or5k8 uc007zog.1 uc007zog.2 uc007zog.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007zog.1 uc007zog.2 uc007zog.3 
ENSMUST00000079957.12 Fcer1g ENSMUST00000079957.12 Fc receptor, IgE, high affinity I, gamma polypeptide (from RefSeq NM_010185.4) ENSMUST00000079957.1 ENSMUST00000079957.10 ENSMUST00000079957.11 ENSMUST00000079957.2 ENSMUST00000079957.3 ENSMUST00000079957.4 ENSMUST00000079957.5 ENSMUST00000079957.6 ENSMUST00000079957.7 ENSMUST00000079957.8 ENSMUST00000079957.9 FCERG_MOUSE Fce1g Fcer1g NM_010185 P20491 uc007dnl.1 uc007dnl.2 uc007dnl.3 Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells (PubMed:14764707). As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset (PubMed:19098920). Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766) (Probable). May function cooperatively with other activating receptors. Functionally linked to integrin beta- 2/ITGB2-mediated neutrophil activation (PubMed:17086186). Also involved in integrin alpha-2/ITGA2-mediated platelet activation (PubMed:9171347). IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Associates with FCGR1A; forms a functional signaling complex (By similarity). The signaling subunit of immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a heterodimer of CD247 and FCER1G, associates with the ligand binding subunit FCGR3A to form a functional receptor complex (By similarity). Associates with CLEC6A (PubMed:17050534). Interacts with CLEC4E (PubMed:23602766, PubMed:18776906). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (PubMed:17086186). Interacts with CSF2RB and recruits SYK in response to IL3 stimulation; this interaction is direct (PubMed:19098920). Interacts with CD300LH; the interaction may be indirect (PubMed:20817736). Interacts with CD300LD (PubMed:20817736). Interacts with TARM1 (By similarity). P20491; Q62120: Jak2; NbExp=2; IntAct=EBI-9306159, EBI-646604; Cell membrane ; Single-pass type I membrane protein Expressed in mast cells (at protein level) (PubMed:14764707). Expressed in basophils (at protein level) (PubMed:19098920). Knockout mice are resistant to IgE-mediated systemic anaphylaxis. Belongs to the CD3Z/FCER1G family. positive regulation of type IIa hypersensitivity positive regulation of type III hypersensitivity positive regulation of type I hypersensitivity neutrophil activation involved in immune response T cell differentiation involved in immune response immune system process Fc receptor mediated stimulatory signaling pathway serotonin secretion by platelet transmembrane signaling receptor activity protein binding plasma membrane integral component of plasma membrane phagocytosis, engulfment signal transduction cell surface receptor signaling pathway integrin-mediated signaling pathway external side of plasma membrane cell surface regulation of platelet activation membrane integral component of membrane immunoglobulin mediated immune response IgE receptor activity IgE binding IgG binding antigen processing and presentation of exogenous peptide antigen via MHC class II osteoclast differentiation neutrophil chemotaxis receptor internalization interleukin-2 production positive regulation of interleukin-10 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of mast cell cytokine production Fc-epsilon receptor I complex negative regulation of mast cell apoptotic process Fc-gamma receptor signaling pathway Fc-epsilon receptor signaling pathway interleukin-3-mediated signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I defense response to bacterium protein homodimerization activity positive regulation of mast cell degranulation innate immune response membrane raft mast cell activation metal ion binding positive regulation of phagocytosis regulation of immune response positive regulation of immune response protein homooligomerization cellular response to low-density lipoprotein particle stimulus protein localization to plasma membrane positive regulation of protein localization to cell surface uc007dnl.1 uc007dnl.2 uc007dnl.3 
ENSMUST00000079970.6 Hspbp1 ENSMUST00000079970.6 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1, transcript variant 1 (from RefSeq NM_024172.4) ENSMUST00000079970.1 ENSMUST00000079970.2 ENSMUST00000079970.3 ENSMUST00000079970.4 ENSMUST00000079970.5 HPBP1_MOUSE Hspbp NM_024172 Q99P31 Q9CYV8 uc009eyc.1 uc009eyc.2 uc009eyc.3 Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity). Interacts with the ATP-binding domain of HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1 (By similarity). Interacts with PGLYRP1; this interaction blocks the cytotoxic activity of the PGLYRP1-HSPA1A complex (By similarity). Sequence=BAB28756.1; Type=Frameshift; Evidence=; adenyl-nucleotide exchange factor activity cytoplasm endoplasmic reticulum positive regulation of protein ubiquitination ubiquitin protein ligase binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of catalytic activity uc009eyc.1 uc009eyc.2 uc009eyc.3 
ENSMUST00000079978.13 Unc13b ENSMUST00000079978.13 unc-13 homolog B, transcript variant 4 (from RefSeq NM_001384106.1) A2AG43 B2RXT0 B2RXY6 ENSMUST00000079978.1 ENSMUST00000079978.10 ENSMUST00000079978.11 ENSMUST00000079978.12 ENSMUST00000079978.2 ENSMUST00000079978.3 ENSMUST00000079978.4 ENSMUST00000079978.5 ENSMUST00000079978.6 ENSMUST00000079978.7 ENSMUST00000079978.8 ENSMUST00000079978.9 NM_001384106 Q6BCX2 Q9Z1N9 UN13B_MOUSE Unc13a Unc13b uc057brq.1 uc057brq.2 uc057brq.3 Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (PubMed:23229896). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with RIMS1. Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus. Synapse Note=Localized to synapses (By similarity). Translocates to the Golgi in response to phorbol ester binding. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Z1N9-1; Sequence=Displayed; Name=2; IsoId=Q9Z1N9-2; Sequence=VSP_039197; Name=3; IsoId=Q9Z1N9-3; Sequence=VSP_039198; The C2 domains are not involved in calcium-dependent phospholipid binding. Belongs to the unc-13 family. non-kinase phorbol ester receptor activity calcium ion binding calmodulin binding phospholipid binding cytoplasm Golgi apparatus cytosol plasma membrane exocytosis chemical synaptic transmission neuromuscular junction development positive regulation of synaptic vesicle priming membrane synaptic vesicle exocytosis synaptic vesicle docking synaptic vesicle priming synaptic vesicle maturation syntaxin-1 binding syntaxin binding diacylglycerol binding cell junction synaptic vesicle membrane GTP-dependent protein binding neuromuscular junction negative regulation of synaptic plasticity early phagosome synaptic transmission, glutamatergic intracellular signal transduction presynaptic membrane positive regulation of apoptotic process terminal bouton calyx of Held synapse positive regulation of exocytosis metal ion binding regulation of short-term neuronal synaptic plasticity presynaptic active zone positive regulation of protein secretion innervation acrosomal vesicle exocytosis spontaneous neurotransmitter secretion dense core granule priming cellular response to glucose stimulus phagosome maturation synaptic membrane positive regulation of inhibitory postsynaptic potential ribbon synapse presynapse presynaptic active zone cytoplasmic component glutamatergic synapse presynaptic dense core vesicle exocytosis positive regulation of defense response to bacterium dense core granule docking uc057brq.1 uc057brq.2 uc057brq.3 
ENSMUST00000079987.13 Las1l ENSMUST00000079987.13 LAS1-like (S. cerevisiae), transcript variant 2 (from RefSeq NM_152822.3) A2BE28 A2BE30 ENSMUST00000079987.1 ENSMUST00000079987.10 ENSMUST00000079987.11 ENSMUST00000079987.12 ENSMUST00000079987.2 ENSMUST00000079987.3 ENSMUST00000079987.4 ENSMUST00000079987.5 ENSMUST00000079987.6 ENSMUST00000079987.7 ENSMUST00000079987.8 ENSMUST00000079987.9 LAS1L_MOUSE NM_152822 Q6KAR5 Q8C742 uc009tud.1 uc009tud.2 uc009tud.3 uc009tud.4 Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9 to form an ITS2 pre- rRNA endonuclease-kinase complex (By similarity). Nucleus, nucleolus Nucleus, nucleoplasm Cytoplasm Note=Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export (By similarity). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2BE28-1; Sequence=Displayed; Name=2; IsoId=A2BE28-2; Sequence=VSP_038670; Belongs to the LAS1 family. maturation of 5.8S rRNA maturation of LSU-rRNA endonuclease activity nucleus nucleoplasm nucleolus cytoplasm rRNA processing preribosome, large subunit precursor MLL1 complex nucleic acid phosphodiester bond hydrolysis uc009tud.1 uc009tud.2 uc009tud.3 uc009tud.4 
ENSMUST00000079996.13 Zfand2a ENSMUST00000079996.13 Cytoplasm Nucleus (from UniProt Q9JII7) AK146082 Airap ENSMUST00000079996.1 ENSMUST00000079996.10 ENSMUST00000079996.11 ENSMUST00000079996.12 ENSMUST00000079996.2 ENSMUST00000079996.3 ENSMUST00000079996.4 ENSMUST00000079996.5 ENSMUST00000079996.6 ENSMUST00000079996.7 ENSMUST00000079996.8 ENSMUST00000079996.9 Q9JII7 ZFN2A_MOUSE uc009agt.1 uc009agt.2 uc009agt.3 uc009agt.4 Cytoplasm Nucleus proteasome complex protein binding nucleus cytoplasm zinc ion binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process metal ion binding cellular response to arsenic-containing substance uc009agt.1 uc009agt.2 uc009agt.3 uc009agt.4 
ENSMUST00000080001.9 Ufc1 ENSMUST00000080001.9 ubiquitin-fold modifier conjugating enzyme 1, transcript variant 1 (from RefSeq NM_025388.3) ENSMUST00000080001.1 ENSMUST00000080001.2 ENSMUST00000080001.3 ENSMUST00000080001.4 ENSMUST00000080001.5 ENSMUST00000080001.6 ENSMUST00000080001.7 ENSMUST00000080001.8 NM_025388 Q9CR09 UFC1_MOUSE Ufc1 uc007dnw.1 uc007dnw.2 uc007dnw.3 E1-like enzyme which specifically catalyzes the second step in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Interacts with UBA5 (via C-terminus). Interacts with UFL1. Interacts with KIRREL3. Interacts with UFM1. Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily. brain development response to endoplasmic reticulum stress UFM1 transferase activity protein ufmylation protein K69-linked ufmylation uc007dnw.1 uc007dnw.2 uc007dnw.3 
ENSMUST00000080008.13 Arfgap2 ENSMUST00000080008.13 ADP-ribosylation factor GTPase activating protein 2, transcript variant 2 (from RefSeq NM_023854.2) ARFG2_MOUSE ENSMUST00000080008.1 ENSMUST00000080008.10 ENSMUST00000080008.11 ENSMUST00000080008.12 ENSMUST00000080008.2 ENSMUST00000080008.3 ENSMUST00000080008.4 ENSMUST00000080008.5 ENSMUST00000080008.6 ENSMUST00000080008.7 ENSMUST00000080008.8 ENSMUST00000080008.9 NM_023854 Q99K28 Q9D758 Q9JIH1 Zfp289 Znf289 uc008kvq.1 uc008kvq.2 uc008kvq.3 uc008kvq.4 This gene encodes a zinc-finger-containing GTPase-activating protein for ADP ribosylation factor 1 (ARF1), a small GTPase that plays a role in coatomer-mediated vesicular trafficking. This gene product stimulates the hydrolysis of ARF1-bound GTP, which may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. It may regulate the retrograde transport from the Golgi complex to the endoplasmic reticulum. Expression of this gene has been shown to be controlled by inhibitor of DNA binding 1 (Id1). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 6. [provided by RefSeq, Oct 2009]. GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). Interacts with the coatomer complex. Interacts with the C- terminal appendage domain of COPG1 (By similarity). Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99K28-1; Sequence=Displayed; Name=2; IsoId=Q99K28-2; Sequence=VSP_023305; Highly expressed in liver, heart and kidney. Low expression in skeletal muscle and spleen. High levels in mammary glands of virgin mice and in mammary glands of pregnant mice associated with extensive proliferation of ductal cells and lobulo-alveolar development. Expression declines at the beginning of lactation when the glands fully differentiate. No expression after day 2 of lactation until day 21. Expression may be controlled by ID1. Golgi membrane GTPase activator activity cytoplasm Golgi apparatus cytosol plasma membrane protein transport membrane vesicle-mediated transport positive regulation of GTPase activity metal ion binding COPI coating of Golgi vesicle COPI vesicle coat uc008kvq.1 uc008kvq.2 uc008kvq.3 uc008kvq.4 
ENSMUST00000080014.2 Or5p79 ENSMUST00000080014.2 olfactory receptor family 5 subfamily P member 79 (from RefSeq NM_146743.1) ENSMUST00000080014.1 Mor204-7 NM_146743 O5P79_MOUSE Olfr507 Or5p79 Q8VG13 uc009jcq.1 uc009jcq.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jcq.1 uc009jcq.2 
ENSMUST00000080030.14 Gspt1 ENSMUST00000080030.14 G1 to S phase transition 1, transcript variant 1 (from RefSeq NM_146066.2) E9QK49 ENSMUST00000080030.1 ENSMUST00000080030.10 ENSMUST00000080030.11 ENSMUST00000080030.12 ENSMUST00000080030.13 ENSMUST00000080030.2 ENSMUST00000080030.3 ENSMUST00000080030.4 ENSMUST00000080030.5 ENSMUST00000080030.6 ENSMUST00000080030.7 ENSMUST00000080030.8 ENSMUST00000080030.9 ERF3A_MOUSE Erf3a G3UWC0 NM_146066 O88179 Q8K2E1 Q8R050 uc007yfe.1 uc007yfe.2 uc007yfe.3 uc007yfe.4 uc007yfe.5 GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA. GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Component of the eRF1-eRF3-GTP ternary complex, composed of ETF1/ERF1 and ERF3 (GSPT1/ERF3A or GSPT2/ERF3B) and GTP. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. The ETF1-GSPT1 complex interacts with JMJD4 (By similarity). Interacts with PABPC1 (Ref.7). Interacts with SHFL (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R050-1; Sequence=Displayed; Name=2; IsoId=Q8R050-2; Sequence=VSP_043829; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily. Sequence=AAH28325.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH31640.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cytoplasmic translational termination translation release factor activity GTPase activity GTP binding cytosol translation regulation of translational termination protein methylation translation release factor complex uc007yfe.1 uc007yfe.2 uc007yfe.3 uc007yfe.4 uc007yfe.5 
ENSMUST00000080035.11 Cd99l2 ENSMUST00000080035.11 CD99 antigen-like 2, transcript variant 2 (from RefSeq NM_138309.3) A2AP77 C99L2_MOUSE ENSMUST00000080035.1 ENSMUST00000080035.10 ENSMUST00000080035.2 ENSMUST00000080035.3 ENSMUST00000080035.4 ENSMUST00000080035.5 ENSMUST00000080035.6 ENSMUST00000080035.7 ENSMUST00000080035.8 ENSMUST00000080035.9 Mic2l1 NM_138309 Q8BIF0 Q8R447 uc009tjz.1 uc009tjz.2 uc009tjz.3 uc009tjz.4 Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Homophilic adhesion molecule, but these interactions may not be required for cell aggregation. Cell membrane ; Single-pass type I membrane protein ; Extracellular side Cell junction Secreted Note=Concentrated at cell-cell contacts in cultured endothelial cells. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long isoform; IsoId=Q8BIF0-1; Sequence=Displayed; Name=2; Synonyms=Short isoform; IsoId=Q8BIF0-2; Sequence=VSP_034186; Highly expressed in the nervous system, including brain, dentate nucleus of hippocampus, granular and Purkinje cells of cerebellum, brain stem nucleus and choroid plexus. Expressed in peripheral blood T- and B-cells and neutrophils (at protein level). Almost undetectable in bone marrow-derived neutrophils (at protein level). Also expressed in thymocytes (at protein level) with higher expression in cortical thymocytes than in medullary thymocytes. Expressed at high levels in testis (mostly in germ cells and Sertoli cells) and ovary (mostly in granulosa cells). Expressed in lung, heart, kidney and liver (at protein level); however, expression in heart, kidney and liver seems restricted to endothelial cells (at protein level). Highly expressed in endothelial cells and to a lower level in vascular smooth muscle cells (at protein level). Low expression in spleen. At 12.5 dpc, expressed in most tissues, especially in the nervous system, including the cerebral cortex, cerebellum, spinal cord and ganglion. There is no change in expression pattern from 12.5 dpc to neonatal day 1. Highly expressed in the subventricular zone and cortical plate of fetal brain and in the dorsal root ganglion of the peripheral nervous system. Except in the nervous system, expression in adult tissues is weaker than in fetal ones. O-glycosylated. [Isoform 2]: Seems to be the major transcript. Belongs to the CD99 family. Sequence=CAM25451.1; Type=Erroneous gene model prediction; Evidence=; plasma membrane cell-cell adherens junction cell adhesion cell surface membrane integral component of membrane cell junction homotypic cell-cell adhesion diapedesis positive regulation of neutrophil extravasation positive regulation of T cell extravasation uc009tjz.1 uc009tjz.2 uc009tjz.3 uc009tjz.4 
ENSMUST00000080036.3 Htt ENSMUST00000080036.3 huntingtin (from RefSeq NM_010414.3) ENSMUST00000080036.1 ENSMUST00000080036.2 G3X9H5 G3X9H5_MOUSE Htt NM_010414 uc008xdc.1 uc008xdc.2 uc008xdc.3 uc008xdc.4 uc008xdc.5 May play a role in microtubule-mediated transport or vesicle function. Cytoplasm Nucleus Belongs to the huntingtin family. establishment of mitotic spindle orientation p53 binding profilin binding nucleus nucleoplasm cytoplasm early endosome late endosome autophagosome endoplasmic reticulum Golgi apparatus centriole cytosol retrograde vesicle-mediated transport, Golgi to ER Golgi organization inclusion body kinase binding axon dendrite cytoplasmic vesicle membrane heat shock protein binding positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity protein destabilization macromolecular complex dynactin binding vocal learning identical protein binding positive regulation of apoptotic process regulation of phosphoprotein phosphatase activity ion channel binding dynein intermediate chain binding positive regulation of cilium assembly vesicle transport along microtubule perinuclear region of cytoplasm beta-tubulin binding presynaptic cytosol postsynaptic cytosol positive regulation of mitophagy positive regulation of lipophagy regulation of CAMKK-AMPK signaling cascade positive regulation of aggrephagy regulation of cAMP-dependent protein kinase activity negative regulation of extrinsic apoptotic signaling pathway uc008xdc.1 uc008xdc.2 uc008xdc.3 uc008xdc.4 uc008xdc.5 
ENSMUST00000080058.11 Egln2 ENSMUST00000080058.11 egl-9 family hypoxia-inducible factor 2, transcript variant 1 (from RefSeq NM_053208.4) EGLN2_MOUSE ENSMUST00000080058.1 ENSMUST00000080058.10 ENSMUST00000080058.2 ENSMUST00000080058.3 ENSMUST00000080058.4 ENSMUST00000080058.5 ENSMUST00000080058.6 ENSMUST00000080058.7 ENSMUST00000080058.8 ENSMUST00000080058.9 Egln2 NM_053208 Q8C6I4 Q8CIL9 Q8VHJ1 Q91YE2 Q99MI0 uc009fva.1 uc009fva.2 uc009fva.3 Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:24809345). Target proteins are preferentially recognized via a LXXLAP motif (By similarity). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:18176562, PubMed:19587290, PubMed:21083501). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:18176562, PubMed:19587290, PubMed:21083501). Also hydroxylates HIF2A (PubMed:18176562, PubMed:19587290, PubMed:21083501). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:18176562, PubMed:19587290, PubMed:21083501). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:18176562, PubMed:19587290, PubMed:21083501). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:18176562, PubMed:19587290, PubMed:21083501). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:18176562, PubMed:19587290, PubMed:21083501). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:18176562, PubMed:19587290, PubMed:21083501). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (By similarity). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (By similarity). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (PubMed:24809345). Reaction=2-oxoglutarate + L-prolyl-[protein] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]; Xref=Rhea:RHEA:63484, Rhea:RHEA- COMP:12408, Rhea:RHEA-COMP:16354, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50342, ChEBI:CHEBI:61965; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63485; Evidence=; Reaction=2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia- inducible factor alpha subunit]; Xref=Rhea:RHEA:48400, Rhea:RHEA- COMP:12093, Rhea:RHEA-COMP:12094, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50342, ChEBI:CHEBI:61965; EC=1.14.11.29; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence= Note=Binds 1 Fe(2+) ion per subunit. Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Interacts with E3 ligase SIAH2. Interacts with LIMD1, WTIP and AJUBA. Nucleus Highly expressed in testis, expression was also detected in the heart brain, liver kidney and lung. Expression was lowest in spleen and skeletal muscle. Constitutively expressed during differentiation of C2C12 skeletal myocytes. The Beta(2)beta(3) 'finger-like' loop domain is important for substrate (HIFs' CODD/NODD) selectivity. Ubiquitinated by SIAH1 and/or SIAH2 in response to the unfolded protein response (UPR), leading to its degradation. Null mice exhibit a lowering of oxygen consumption in skeletal muscle. Glucose oxidation is reduced to around 35%. Hypoxia tolerance is induced in myofibers. Sequence=CAC42516.1; Type=Frameshift; Evidence=; response to hypoxia iron ion binding nucleus nucleoplasm ferrous iron binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors peptidyl-proline hydroxylation to 4-hydroxy-L-proline oxygen sensor activity L-ascorbic acid binding peptidyl-proline 4-dioxygenase activity regulation of neuron apoptotic process cell redox homeostasis positive regulation of protein catabolic process metal ion binding dioxygenase activity oxidation-reduction process uc009fva.1 uc009fva.2 uc009fva.3 
ENSMUST00000080065.3 Slc27a4 ENSMUST00000080065.3 solute carrier family 27 (fatty acid transporter), member 4 (from RefSeq NM_011989.5) Acsvl4 ENSMUST00000080065.1 ENSMUST00000080065.2 Fatp4 NM_011989 O88562 Q3TD48 Q91VE0 S27A4_MOUSE Slc27a4 uc008jaf.1 uc008jaf.2 uc008jaf.3 Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes (PubMed:10518211, PubMed:20448275). Appears to be the principal fatty acid transporter in small intestinal enterocytes (PubMed:20448275). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (By similarity). Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (PubMed:11404000, PubMed:12821645, PubMed:15653672, PubMed:15699031). Probably involved in fatty acid transport across the blood barrier (By similarity). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl- CoA. Prevents light-induced degeneration of rods and cones (PubMed:23407971). Reaction=a fatty acid(in) = a fatty acid(out); Xref=Rhea:RHEA:38879, ChEBI:CHEBI:28868; Evidence= Reaction=(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)- octadecadienoate(in); Xref=Rhea:RHEA:45264, ChEBI:CHEBI:30245; Evidence=; Reaction=(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in); Xref=Rhea:RHEA:33655, ChEBI:CHEBI:30823; Evidence=; Reaction=hexadecanoate(out) = hexadecanoate(in); Xref=Rhea:RHEA:45256, ChEBI:CHEBI:7896; Evidence=; Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl- CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:456215; EC=6.2.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19714; Evidence=; Reaction=(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:33607, ChEBI:CHEBI:30616, ChEBI:CHEBI:30823, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33608; Evidence=; Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl- CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30752; Evidence=; Reaction=(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:36139, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61526, ChEBI:CHEBI:72745, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36140; Evidence=; Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537; Evidence=; Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616, ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Most abundantly expressed in small intestine, brain, kidney, liver, skin and heart. In small intestine, expressed at high levels on the apical side of mature enterocytes. Highly expressed by the epithelial cells of the visceral endoderm and localized to the brush-border membrane of extraembryonic endodermal cells (at protein level). Expressed in the retinal pigment epithelium and in the retina (at protein level). Expressed in the retinal pigment epithelium and in the retina. Note=Defects in Slc27a4 are the cause of wrinkle-free (wrfr) phenotype. It is a spontaneous, autosomal recessive mutation resulting in very tight, thick skin and is secondary characterized by severe breathing difficulties. Mice die shortly after birth. This phenotype is similar to human restrictive dermopathy, a very rare human genetic disorder. Slc27a4 deficient mice display features of a neonatally lethal restrictive dermopathy. Their skin is characterized by hyperproliferative hyperkeratosis with a disturbed epidermal barrier, a flat dermal-epidermal junction, a reduced number of pilo-sebaceous structures, and a compact dermis. The rigid skin consistency results in an altered body shape with facial dysmorphia, generalized joint flexion contractures and impaired movement including suckling and breathing deficiencies. Lipid analysis demonstrates a disturbed fatty acid composition of epidermal ceramides, in particular a decrease in the C26:0 and C26:0-OH fatty acid substitutes. Deletion of Slc27a4 results in embryonic lethality, which has been attributed to a requirement for fat absorption early in embryonic development across the visceral endoderm. Belongs to the ATP-dependent AMP-binding enzyme family. Sequence=AAC40188.1; Type=Frameshift; Evidence=; Sequence=AAC40188.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; very long-chain fatty acid metabolic process nucleotide binding medium-chain fatty acid transport long-chain fatty acid metabolic process catalytic activity long-chain fatty acid-CoA ligase activity long-chain fatty acid transporter activity endoplasmic reticulum endoplasmic reticulum membrane plasma membrane microvillus lipid metabolic process fatty acid metabolic process lipid transport response to nutrient fatty acid transport long-chain fatty acid transport membrane integral component of membrane ligase activity brush border membrane very long-chain fatty acid-CoA ligase activity very long-chain fatty acid catabolic process skin development long-chain fatty acid import uc008jaf.1 uc008jaf.2 uc008jaf.3 
ENSMUST00000080067.13 Slc4a2 ENSMUST00000080067.13 solute carrier family 4 (anion exchanger), member 2, transcript variant 1 (from RefSeq NM_009207.3) A0A0R4J101 A0A0R4J101_MOUSE ENSMUST00000080067.1 ENSMUST00000080067.10 ENSMUST00000080067.11 ENSMUST00000080067.12 ENSMUST00000080067.2 ENSMUST00000080067.3 ENSMUST00000080067.4 ENSMUST00000080067.5 ENSMUST00000080067.6 ENSMUST00000080067.7 ENSMUST00000080067.8 ENSMUST00000080067.9 NM_009207 Slc4a2 uc008wrm.1 uc008wrm.2 uc008wrm.3 uc008wrm.4 Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) + hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996; Evidence=; Apical cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Lateral cell membrane ; Multi-pass membrane protein Membrane ; Multi- pass membrane protein Belongs to the anion exchanger (TC 2.A.31) family. inorganic anion exchanger activity ion transport anion transport spermatogenesis anion transmembrane transporter activity inorganic anion transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane enzyme binding digestive tract development regulation of intracellular pH anion transmembrane transport uc008wrm.1 uc008wrm.2 uc008wrm.3 uc008wrm.4 
ENSMUST00000080083.3 Srsf8 ENSMUST00000080083.3 RIKEN cDNA 4930595M18 gene (from RefSeq NM_173435.3) 4930595M18Rik A2RRY9 A2RRY9_MOUSE ENSMUST00000080083.1 ENSMUST00000080083.2 NM_173435 uc009trf.1 uc009trf.2 uc009trf.3 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus nuclear speck mRNA cis splicing, via spliceosome uc009trf.1 uc009trf.2 uc009trf.3 
ENSMUST00000080085.9 Krit1 ENSMUST00000080085.9 KRIT1, ankyrin repeat containing, transcript variant 1 (from RefSeq NM_030675.3) Ccm1 ENSMUST00000080085.1 ENSMUST00000080085.2 ENSMUST00000080085.3 ENSMUST00000080085.4 ENSMUST00000080085.5 ENSMUST00000080085.6 ENSMUST00000080085.7 ENSMUST00000080085.8 KRIT1_MOUSE NM_030675 Q6S5J6 Q6VSV2 Q7TPR8 Q8C9Q6 Q9EPY2 Q9ERH0 uc008wht.1 uc008wht.2 uc008wht.3 uc008wht.4 Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH- dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule- associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner (By similarity). Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels. May play a role in the regulation of macroautophagy through the down-regulation of the mTOR pathway (PubMed:26417067). Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (via C-terminus FERM domain) with RAP1A (active GTP- bound form preferentially); the interaction does not induce the opening conformation of KRIT1. Interacts (via N-terminus NPXY motif) with ITGB1BP1; the interaction induces the opening conformation of KRIT1 and competes with ITGB1 for ITGB1BP1 interaction. Associates (via N- terminus and C-terminus regions) with microtubules; the interaction is inhibited in presence of ITGB1BP1 and active GTP-bound RAP1A. Interacts (via FERM domain) with RAP1B. Interacts with CDH5. Interacts with RAP1A (By similarity). Interacts with HEG1 and CCM2; greatly facilitates CCM2-binding to HEG1 (PubMed:19151727). Cytoplasm, cytoskeleton Cell membrane ; Peripheral membrane protein Cell junction Note=KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. Association with RAP1 relocalizes KRIT1 from microtubules to cell junction membranes. Translocates from the cytoplasm along microtubules to the cell membrane in an ITGB1BP1-dependent manner (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Krit1A; IsoId=Q6S5J6-1; Sequence=Displayed; Name=2; Synonyms=Krit1B; IsoId=Q6S5J6-2; Sequence=VSP_015803; Name=3; IsoId=Q6S5J6-3; Sequence=VSP_015801; Name=4; IsoId=Q6S5J6-4; Sequence=VSP_015802; Expressed in heart, brain, spleen, lung, thymus, kidney and testis. Isoform 2 was more frequently expressed in the thymus than isoform 1. At stage 9.5 dpc ubiquitously expressed, at 12.5 dpc expressed in structures of the CNS, especially in zones of the proliferative active ventricular zones of the brain and in the spinal cord. Expression increased in organs that were in the state of organ expansion like lung and liver. At 17.5 dpc, expression was strongly reduced in endoderm-derived tissues. In early postnatal development, strongly expressed in regions of ossification. The FERM domain mediates binding to RAP1A and RAP1B and is necessary for binding to phosphatidylinositol 4,5-bisphosphate (PIP2). The N-terminal domain has structural similarity to the nudix hydrolase domain, despite the absence of a nudix box and low sequence similarity with nudix hydrolase domains. The N-terminus and the C- terminus part associate together via the NPAY binding motif and adopt a lose conformation that is disrupted by ITGB1BP1, but not by RAP1A. Contains 4 ANK repeats that precede the FERM domain. angiogenesis negative regulation of endothelial cell proliferation protein binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm cytoskeleton plasma membrane cell-cell junction microtubule binding negative regulation of endothelial cell migration membrane negative regulation of angiogenesis cell junction GTPase regulator activity positive regulation of protein binding macromolecular complex cell redox homeostasis regulation of catalytic activity regulation of establishment of cell polarity negative regulation of endothelial cell apoptotic process uc008wht.1 uc008wht.2 uc008wht.3 uc008wht.4 
ENSMUST00000080106.2 Or5p68 ENSMUST00000080106.2 olfactory receptor family 5 subfamily P member 68 (from RefSeq NM_146310.1) ENSMUST00000080106.1 Mor204-35 NM_146310 O5P68_MOUSE Olfr493 Or5p68 Q8VEW5 uc009jch.1 uc009jch.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jch.1 uc009jch.2 
ENSMUST00000080123.2 Aldoart2 ENSMUST00000080123.2 aldolase 1 A, retrogene 2 (from RefSeq NM_001277340.1) A6ZI47 A6ZI47_MOUSE Aldoart2 ENSMUST00000080123.1 NM_001277340 uc007nos.1 uc007nos.2 uc007nos.3 uc007nos.4 uc007nos.5 Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3- phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729, ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=4.1.2.13; Evidence=; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 4/4. Belongs to the class I fructose-bisphosphate aldolase family. catalytic activity fructose-bisphosphate aldolase activity cytosol glycolytic process lyase activity fructose 1,6-bisphosphate metabolic process uc007nos.1 uc007nos.2 uc007nos.3 uc007nos.4 uc007nos.5 
ENSMUST00000080126.4 Rnase1 ENSMUST00000080126.4 ribonuclease, RNase A family, 1 (pancreatic) (from RefSeq NM_011271.3) ENSMUST00000080126.1 ENSMUST00000080126.2 ENSMUST00000080126.3 NM_011271 Q8C6G3 Q8C6G3_MOUSE Rnase1 uc007tms.1 uc007tms.2 uc007tms.3 Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double- stranded RNA. Reaction=an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].; EC=4.6.1.18; Evidence=; Reaction=an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].; EC=4.6.1.18; Evidence=; Secreted Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity ribonuclease activity hydrolase activity RNA phosphodiester bond hydrolysis uc007tms.1 uc007tms.2 uc007tms.3 
ENSMUST00000080132.3 4921509C19Rik ENSMUST00000080132.3 RIKEN cDNA 4921509C19 gene (from RefSeq NM_198655.2) ENSMUST00000080132.1 ENSMUST00000080132.2 NM_198655 Q8C0X8 SMKX_MOUSE uc008ndv.1 uc008ndv.2 uc008ndv.3 May play a role in sperm motility, especially in the regulation of flagellar function. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity intracellular signal transduction uc008ndv.1 uc008ndv.2 uc008ndv.3 
ENSMUST00000080135.5 Adam26b ENSMUST00000080135.5 a disintegrin and metallopeptidase domain 26B (from RefSeq NM_001009547.2) Adam26b ENSMUST00000080135.1 ENSMUST00000080135.2 ENSMUST00000080135.3 ENSMUST00000080135.4 NM_001009547 Q6IMH6 Q6IMH6_MOUSE uc009loe.1 uc009loe.2 uc009loe.3 Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function metalloendopeptidase activity cellular_component proteolysis biological_process metallopeptidase activity membrane integral component of membrane uc009loe.1 uc009loe.2 uc009loe.3 
ENSMUST00000080141.6 Tmem117 ENSMUST00000080141.6 transmembrane protein 117 (from RefSeq NM_178789.4) ENSMUST00000080141.1 ENSMUST00000080141.2 ENSMUST00000080141.3 ENSMUST00000080141.4 ENSMUST00000080141.5 NM_178789 Q8BH18 Q8C6X8 TM117_MOUSE uc007xjn.1 uc007xjn.2 uc007xjn.3 Involved in endoplasmic reticulum (ER) stress-induced cell death pathway. Cell membrane ; Multi-pass membrane protein Belongs to the TMEM117 family. Sequence=BAC35210.1; Type=Erroneous initiation; Evidence=; molecular_function endoplasmic reticulum plasma membrane membrane integral component of membrane intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress uc007xjn.1 uc007xjn.2 uc007xjn.3 
ENSMUST00000080145.13 Adamts16 ENSMUST00000080145.13 ADAM metallopeptidase with thrombospondin type 1 motif 16, transcript variant 1 (from RefSeq NM_172053.4) ATS16_MOUSE ENSMUST00000080145.1 ENSMUST00000080145.10 ENSMUST00000080145.11 ENSMUST00000080145.12 ENSMUST00000080145.2 ENSMUST00000080145.3 ENSMUST00000080145.4 ENSMUST00000080145.5 ENSMUST00000080145.6 ENSMUST00000080145.7 ENSMUST00000080145.8 ENSMUST00000080145.9 Kiaa2029 NM_172053 Q69Z28 Q8K206 uc007rcz.1 uc007rcz.2 uc007rcz.3 This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is co-expressed with the Wilms tumor protein, Wt1, in the developing glomeruli of embryonic kidneys. The encoded preproprotein undergoes proteolytic processing to generate an active enzyme. [provided by RefSeq, Jul 2016]. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69Z28-1; Sequence=Displayed; Name=2; IsoId=Q69Z28-2; Sequence=VSP_014991, VSP_014992; The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2- G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3- glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). branching involved in ureteric bud morphogenesis regulation of systemic arterial blood pressure molecular_function metalloendopeptidase activity extracellular region proteolysis peptidase activity metallopeptidase activity hydrolase activity metal ion binding male gamete generation regulation of cilium assembly uc007rcz.1 uc007rcz.2 uc007rcz.3 
ENSMUST00000080152.5 Erhrt-ps ENSMUST00000080152.5 May have a role in the cell cycle. (from UniProt Q4FZH7) AK168188 ENSMUST00000080152.1 ENSMUST00000080152.2 ENSMUST00000080152.3 ENSMUST00000080152.4 Erh Q4FZH7 Q4FZH7_MOUSE uc291zgu.1 uc291zgu.2 May have a role in the cell cycle. Belongs to the E(R) family. cell cycle uc291zgu.1 uc291zgu.2 
ENSMUST00000080162.2 Or10w1 ENSMUST00000080162.2 olfactory receptor family 10 subfamily W member 1 (from RefSeq NM_001011832.1) ENSMUST00000080162.1 NM_001011832 Olfr1490 Or10w1 Q7TQQ5 Q7TQQ5_MOUSE uc008gvv.1 uc008gvv.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gvv.1 uc008gvv.2 
ENSMUST00000080165.5 Or14c39 ENSMUST00000080165.5 olfactory receptor family 14 subfamily C member 39 (from RefSeq NM_146620.2) ENSMUST00000080165.1 ENSMUST00000080165.2 ENSMUST00000080165.3 ENSMUST00000080165.4 F8VQ84 F8VQ84_MOUSE NM_146620 Olfr292 Or14c39 uc009ifg.1 uc009ifg.2 uc009ifg.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB173961.1, CB173294.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Odorant receptor. Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ifg.1 uc009ifg.2 uc009ifg.3 
ENSMUST00000080171.3 Cyp2c50 ENSMUST00000080171.3 cytochrome P450, family 2, subfamily c, polypeptide 50, transcript variant 1 (from RefSeq NM_134144.2) CY250_MOUSE Cyp2c50 E9QPJ0 ENSMUST00000080171.1 ENSMUST00000080171.2 NM_134144 Q6XVG3 Q80X43 Q91X77 uc008hki.1 uc008hki.2 uc008hki.3 uc008hki.4 Metabolizes arachidonic acid to several midchain and omega- terminal hydroxyeicosatetraenoic acids (HETE). Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q91X77-1; Sequence=Displayed; Name=2 ; IsoId=Q91X77-2; Sequence=VSP_052374; Expressed in heart and liver. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen arachidonic acid metabolic process epoxygenase P450 pathway heme binding organelle membrane exogenous drug catabolic process intracellular membrane-bounded organelle linoleic acid metabolic process metal ion binding oxidation-reduction process aromatase activity linoleic acid epoxygenase activity uc008hki.1 uc008hki.2 uc008hki.3 uc008hki.4 
ENSMUST00000080202.12 Sirt7 ENSMUST00000080202.12 sirtuin 7, transcript variant 1 (from RefSeq NM_153056.3) A2ABY7 ENSMUST00000080202.1 ENSMUST00000080202.10 ENSMUST00000080202.11 ENSMUST00000080202.2 ENSMUST00000080202.3 ENSMUST00000080202.4 ENSMUST00000080202.5 ENSMUST00000080202.6 ENSMUST00000080202.7 ENSMUST00000080202.8 ENSMUST00000080202.9 NM_153056 Q6X7B7 Q8BKJ9 Q8QZZ5 SIR7_MOUSE Sir2l7 Sirt7 uc011yjf.1 uc011yjf.2 uc011yjf.3 NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase and deglutarylase), depending on the context (PubMed:25200183, PubMed:30026585, PubMed:31075303). Also acts as a dedecanoylase (By similarity). Specifically mediates deacetylation of histone H3 at 'Lys- 18' (H3K18Ac) (By similarity). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression (By similarity). H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts as a transcription repressor (By similarity). Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells (By similarity). Also able to mediate deacetylation of histone H3 at 'Lys-36' (H3K36Ac) in the context of nucleosomes (By similarity). Also mediates deacetylation of non-histone proteins, such as ATM, CDK9, DDX21, DDB1, FBL, FKBP5/FKBP51, GABPB1, RAN, RRP9/U3-55K and POLR1E/PAF53 (By similarity). Enriched in nucleolus where it stimulates transcription activity of the RNA polymerase I complex (PubMed:16618798). Acts by mediating the deacetylation of the RNA polymerase I subunit POLR1E/PAF53, thereby promoting the association of RNA polymerase I with the rDNA promoter region and coding region (By similarity). In response to metabolic stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased RNA polymerase I transcription (By similarity). Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis (PubMed:16618798). Promotes pre-ribosomal RNA (pre-rRNA) cleavage at the 5'-terminal processing site by mediating deacetylation of RRP9/U3- 55K, a core subunit of the U3 snoRNP complex (By similarity). Mediates 'Lys-37' deacetylation of Ran, thereby regulating the nuclear export of NF-kappa-B subunit RELA/p65 (PubMed:31075303). Acts as a regulator of DNA damage repair by mediating deacetylation of ATM during the late stages of DNA damage response, promoting ATM dephosphorylation and deactivation (By similarity). May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation (PubMed:18239138). Suppresses the activity of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes by mediating deacetylation of DDB1, which prevents the interaction between DDB1 and CUL4 (CUL4A or CUL4B) (By similarity). Activates RNA polymerase II transcription by mediating deacetylation of CDK9, thereby promoting 'Ser-2' phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (By similarity). Deacetylates FBL, promoting histone-glutamine methyltransferase activity of FBL (By similarity). Acts as a regulator of mitochondrial function by catalyzing deacetylation of GABPB1 (PubMed:25200183). Regulates Akt/AKT1 activity by mediating deacetylation of FKBP5/FKBP51 (By similarity). Required to prevent R- loop-associated DNA damage and transcription-associated genomic instability by mediating deacetylation and subsequent activation of DDX21, thereby overcoming R-loop-mediated stalling of RNA polymerases (By similarity). In addition to protein deacetylase activity, also acts as protein-lysine deacylase (By similarity). Acts as a protein depropionylase by mediating depropionylation of Osterix (SP7), thereby regulating bone formation by osteoblasts (PubMed:30026585). Acts as a histone deglutarylase by mediating deglutarylation of histone H4 on 'Lys-91' (H4K91glu); a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (By similarity). Acts as a histone desuccinylase: in response to DNA damage, recruited to DNA double-strand breaks (DSBs) and catalyzes desuccinylation of histone H3 on 'Lys-122' (H3K122succ), thereby promoting chromatin condensation and DSB repair (By similarity). Also promotes DSB repair by promoting H3K18Ac deacetylation, regulating non-homologous end joining (NHEJ) (PubMed:27225932). Along with its role in DNA repair, required for chromosome synapsis during prophase I of female meiosis by catalyzing H3K18Ac deacetylation (PubMed:31256246). Involved in transcriptional repression of LINE-1 retrotransposon via H3K18Ac deacetylation, and promotes their association with the nuclear lamina (PubMed:31226208). Required to stabilize ribosomal DNA (rDNA) heterochromatin and prevent cellular senescence induced by rDNA instability (PubMed:28842251). Acts as a negative regulator of SIRT1 by preventing autodeacetylation of SIRT1, restricting SIRT1 deacetylase activity (PubMed:28923965). Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43637; Evidence=; Reaction=H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O- glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:47664, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11875, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:87828, ChEBI:CHEBI:87829; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47665; Evidence=; Reaction=H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O- succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:47668, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11877, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:87830, ChEBI:CHEBI:87832; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47669; Evidence=; Reaction=H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O- propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:23500, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13758, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:138019, ChEBI:CHEBI:145015; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23501; Evidence=; Reaction=H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) = 2''-O- decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:70631, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:17932, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:143222, ChEBI:CHEBI:189688; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70632; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; NAD-dependent protein-lysine deacetylase and deacylase activities are activated by nucleic acids. Histone deacetylase activity is activated by DNA. Protein-lysine deacylase activity is activated by RNA. H3K18Ac histone deacetylase activity is inhibited by methylation at Arg-390. H3K18Ac histone deacetylase activity is inhibited by deubiquitination by USP7. Interacts with UBTF and the RNA polymerase I complex (By similarity). Interacts with components of the B-WICH complex, such as MYBBP1A, SMARCA5/SNF2H and BAZ1B/WSTF (By similarity). Interacts with ELK4, leading to stabilization at target promoters for H3K18Ac deacetylation (By similarity). Interacts with histone H2A and/or histone H2B (By similarity). Interacts with DNMT1 (PubMed:28842251). Interacts with SIRT1 (PubMed:28842251, PubMed:28923965). Nucleus, nucleolus cleus, nucleoplasm Chromosome toplasm Note=Mainly localizes in the nucleolus and nucleoplasm (By similarity). Associated with rDNA promoter and transcribed region (By similarity). Associated with nucleolar organizer regions during mitosis (By similarity). In response to stress, released from nucleolus to nucleoplasm (By similarity). Associated with chromatin (By similarity). In response to DNA damage, recruited to DNA double-strand breaks (DSBs) sites (PubMed:27225932). Located close to the nuclear membrane when in the cytoplasm (By similarity). Detected in liver, spleen and testis (PubMed:16618798). Detected in embryos (PubMed:16618798). Phosphorylated during mitosis. Methylation at Arg-390 by PRMT6 inhibits the H3K18Ac histone deacetylase activity, promoting mitochondria biogenesis and maintaining mitochondria respiration. Ubiquitinated via 'Lys-63'-linked ubiquitin chains. Deubiquitinated by USP7, inhibiting the H3K18Ac histone deacetylase activity and regulating gluconeogenesis. Ubiquitinated by E3 ubiquitin- protein ligase complex containing FBXO7; leading to proteasomal degradation. Mice show a reduction in lifespan and develop heart hypertrophy (PubMed:18239138). The mean and maximum lifespan is reduced by 59% and 55% (PubMed:18239138). Mice develop kyphosis and lose subcutaneous fat early in life; they also show a general decrease in stress-resistance mechanisms (PubMed:18239138). Mice suffer from degenerative heart hypertrophy and inflammatory cardiomyopathy (PubMed:18239138). Hearts are also characterized by an extensive fibrosis (PubMed:18239138). Mice also display multisystemic mitochondrial dysfunction, characterized by increased blood lactate levels, reduced exercise performance, cardiac dysfunction, hepatic microvesicular steatosis and age-related hearing loss (PubMed:25200183). Cells show impaired oxidative phosphorylation (OxPhos) (PubMed:25200183). A substantial proportion of mice also show perinatal lethality and an accelerated aging phenotype, probably caused by increased replication stress and impaired DNA caused repair (PubMed:27225932). Females display reduced fertility and produce fewer oocytes and ovulate fewer eggs (PubMed:31256246). Oocytes show impaired meiotic progression with reduced levels of crossovers and chromosome synapsis defects (PubMed:31256246). Mice also show severe osteopenia characterized by decreased bone formation and an increase of osteoclasts (PubMed:30026585). Belongs to the sirtuin family. Class IV subfamily. Sequence=AAH26403.1; Type=Erroneous initiation; Evidence=; Sequence=AAH26650.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter chromatin binding histone deacetylase activity nucleus nuclear telomeric heterochromatin nucleolus nucleolus organizer region cytoplasm chromatin organization positive regulation of transcription involved in exit from mitosis rRNA transcription hydrolase activity metal ion binding NAD+ binding histone H3 deacetylation histone H4 deacetylation NAD-dependent histone deacetylase activity (H3-K18 specific) uc011yjf.1 uc011yjf.2 uc011yjf.3 
ENSMUST00000080204.11 Sp140 ENSMUST00000080204.11 Sp140 nuclear body protein, transcript variant 8 (from RefSeq NR_185232.1) ENSMUST00000080204.1 ENSMUST00000080204.10 ENSMUST00000080204.2 ENSMUST00000080204.3 ENSMUST00000080204.4 ENSMUST00000080204.5 ENSMUST00000080204.6 ENSMUST00000080204.7 ENSMUST00000080204.8 ENSMUST00000080204.9 NR_185232 Q6NSQ5 Q6NSQ5_MOUSE Sp140 uc007buc.1 uc007buc.2 uc007buc.3 Cytoplasm RNA polymerase II core promoter proximal region sequence-specific DNA binding fibrillar center DNA binding nucleus mitochondrion regulation of transcription from RNA polymerase II promoter nuclear body metal ion binding uc007buc.1 uc007buc.2 uc007buc.3 
ENSMUST00000080208.7 Epb41l3 ENSMUST00000080208.7 erythrocyte membrane protein band 4.1 like 3, transcript variant 1 (from RefSeq NM_013813.2) Dal1 E41L3_MOUSE ENSMUST00000080208.1 ENSMUST00000080208.2 ENSMUST00000080208.3 ENSMUST00000080208.4 ENSMUST00000080208.5 ENSMUST00000080208.6 Epb4.1l3 Epb41l3 Kiaa0987 NM_013813 Q69ZT8 Q9R102 Q9WV92 uc008dkp.1 uc008dkp.2 uc008dkp.3 Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, including PRMT3 and PRMT5 (By similarity). Interacts (via FERM domain) with CADM1. Interacts (via FERM domain) with PRMT3; the interaction is direct and inhibits the protein- arginine N-methyltransferase activity of PRMT3. Interacts with PRMT5. Interacts with PRMT6. [Isoform 2]: Has the complete spectrin--actin-binding (SAB) domain and fully interacts with spectrin and actin. Cytoplasm, cytoskeleton Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm Cell junction Note=Detected in the cytoplasm of actively dividing cells. Event=Alternative splicing; Named isoforms=8; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=4.1B-brain; IsoId=Q9WV92-1; Sequence=Displayed; Name=2; Synonyms=4.1B-heart; IsoId=Q9WV92-2; Sequence=VSP_000490, VSP_000489; Name=3; Synonyms=4.1B-kidney; IsoId=Q9WV92-3; Sequence=VSP_000490; Name=4; Synonyms=4.1b-brain; IsoId=Q9WV92-4; Sequence=VSP_000491; Name=5; Synonyms=4.1B-heart; IsoId=Q9WV92-5; Sequence=VSP_000490, VSP_000489, VSP_000491; Name=6; Synonyms=4.1B-kidney; IsoId=Q9WV92-6; Sequence=VSP_000490, VSP_000491; Name=7; IsoId=Q9WV92-7; Sequence=VSP_000487, VSP_000490, VSP_000488, VSP_000491; Name=8; IsoId=Q9WV92-8; Sequence=VSP_000487, VSP_023063, VSP_000491; Detected in brain (at protein level). Highest expression in brain, lower in testis, adrenal gland, heart and kidney. Also present in muscle and epithelial cells. Isoform 1 is expressed in brain, isoform 2 is expressed in heart and isoform 3 is mostly expressed in kidney but also in heart and brain. Isoform 6 seems to be most abundant in kidney while isoform 4 and isoform 5 are predominantly expressed in heart and brain. The complete SAB domain is present only in the heart- specific isoforms (isoform 2 and isoform 5). [Isoform 7]: Inferred from the cDNA sequence of Ref.2. Sequence=AAD51365.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; regulation of cell growth protein localization to paranode region of axon actin binding structural molecule activity structural constituent of cytoskeleton cytoplasm cytoskeleton plasma membrane cell-cell junction apoptotic process cytoskeleton organization cytoskeletal anchoring at plasma membrane cytoskeletal protein binding regulation of cell shape postsynaptic density membrane cell junction cortical cytoskeleton organization cortical actin cytoskeleton organization paranodal junction assembly actomyosin structure organization paranode region of axon myelin maintenance juxtaparanode region of axon neuron projection morphogenesis protein localization to juxtaparanode region of axon protein localization to plasma membrane axolemma uc008dkp.1 uc008dkp.2 uc008dkp.3 
ENSMUST00000080210.10 Slc1a2 ENSMUST00000080210.10 solute carrier family 1 (glial high affinity glutamate transporter), member 2, transcript variant 1 (from RefSeq NM_001077514.4) ENSMUST00000080210.1 ENSMUST00000080210.2 ENSMUST00000080210.3 ENSMUST00000080210.4 ENSMUST00000080210.5 ENSMUST00000080210.6 ENSMUST00000080210.7 ENSMUST00000080210.8 ENSMUST00000080210.9 NM_001077514 Q3UYK6 Q3UYK6_MOUSE RP23-163L4.1-001 Slc1a2 uc008lid.1 uc008lid.2 uc008lid.3 uc008lid.4 Membrane ulti-pass membrane protein Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. L-glutamate transmembrane transporter activity high-affinity glutamate transmembrane transporter activity integral component of plasma membrane cell surface symporter activity glutamate:sodium symporter activity L-glutamate transport membrane integral component of membrane protein homotrimerization D-aspartate import L-glutamate import across plasma membrane integral component of presynaptic membrane uc008lid.1 uc008lid.2 uc008lid.3 uc008lid.4 
ENSMUST00000080215.6 Chst15 ENSMUST00000080215.6 carbohydrate sulfotransferase 15, transcript variant 1 (from RefSeq NM_029935.6) Brag CHSTF_MOUSE ENSMUST00000080215.1 ENSMUST00000080215.2 ENSMUST00000080215.3 ENSMUST00000080215.4 ENSMUST00000080215.5 Galnac4s6st Kiaa0598 NM_029935 Q80TW4 Q8BLQ5 Q91XQ5 Q9D2N6 uc009kby.1 uc009kby.2 uc009kby.3 Sulfotransferase that transfers sulfate from 3'- phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo (By similarity). Reaction=n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate = n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+); Xref=Rhea:RHEA:54304, Rhea:RHEA-COMP:9965, Rhea:RHEA-COMP:13850, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58465, ChEBI:CHEBI:138121; EC=2.8.2.33; Reaction=n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate = n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+); Xref=Rhea:RHEA:54300, Rhea:RHEA-COMP:9829, Rhea:RHEA-COMP:13849, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58422, ChEBI:CHEBI:138112; EC=2.8.2.33; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Name=glutathione; Xref=ChEBI:CHEBI:57925; Evidence=; Inhibited by phenyl beta-GalNAc(4,6-SO(4)). Homodimer; disulfide-linked (Potential). The relevance of homodimerization is however unsure. May interact with phosphorylated proteins in resting B-cells, including HCK (By similarity). Golgi apparatus membrane ; Single- pass type II membrane protein Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor. Glycosylated. Belongs to the sulfotransferase 1 family. Sequence=BAC65606.1; Type=Erroneous initiation; Evidence=; Golgi membrane Golgi apparatus membrane integral component of membrane transferase activity hexose biosynthetic process 3'-phosphoadenosine 5'-phosphosulfate binding N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity uc009kby.1 uc009kby.2 uc009kby.3 
ENSMUST00000080217.14 Ppm1b ENSMUST00000080217.14 protein phosphatase 1B, magnesium dependent, beta isoform, transcript variant 7 (from RefSeq NM_001411571.1) ENSMUST00000080217.1 ENSMUST00000080217.10 ENSMUST00000080217.11 ENSMUST00000080217.12 ENSMUST00000080217.13 ENSMUST00000080217.2 ENSMUST00000080217.3 ENSMUST00000080217.4 ENSMUST00000080217.5 ENSMUST00000080217.6 ENSMUST00000080217.7 ENSMUST00000080217.8 ENSMUST00000080217.9 NM_001411571 Ppm1b Q99NF7 Q99NF7_MOUSE ppm1b2 uc008dtg.1 uc008dtg.2 uc008dtg.3 uc008dtg.4 Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Cytoplasm, cytosol Membrane ; Lipid-anchor Belongs to the PP2C family. magnesium ion binding catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein dephosphorylation hydrolase activity manganese ion binding cation binding metal ion binding uc008dtg.1 uc008dtg.2 uc008dtg.3 uc008dtg.4 
ENSMUST00000080249.6 Zfp947 ENSMUST00000080249.6 zinc finger protein 947 (from RefSeq NM_177596.4) EG210853 ENSMUST00000080249.1 ENSMUST00000080249.2 ENSMUST00000080249.3 ENSMUST00000080249.4 ENSMUST00000080249.5 Gm4769 NM_177596 Q8BIQ6 Q8BIQ6_MOUSE Zfp947 uc008arn.1 uc008arn.2 uc008arn.3 Nucleus molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008arn.1 uc008arn.2 uc008arn.3 
ENSMUST00000080253.5 Vmn1r216 ENSMUST00000080253.5 vomeronasal 1 receptor 216 (from RefSeq NM_134245.1) ENSMUST00000080253.1 ENSMUST00000080253.2 ENSMUST00000080253.3 ENSMUST00000080253.4 NM_134245 Q8R257 Q8R257_MOUSE V1ri10 Vmn1r216 uc288lkl.1 uc288lkl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lkl.1 uc288lkl.2 
ENSMUST00000080254.7 Btnl1 ENSMUST00000080254.7 butyrophilin-like 1 (from RefSeq NM_001111094.1) A6X8K2 BTNL1_MOUSE Btnl3 ENSMUST00000080254.1 ENSMUST00000080254.2 ENSMUST00000080254.3 ENSMUST00000080254.4 ENSMUST00000080254.5 ENSMUST00000080254.6 G3UZN0 Gm316 NM_001111094 Ng10 O70356 Q7TST0 uc012apy.1 uc012apy.2 uc012apy.3 uc012apy.4 Membrane ; Single-pass type I membrane protein Belongs to the immunoglobulin superfamily. BTN/MOG family. Sequence=AAC05289.1; Type=Erroneous gene model prediction; Evidence=; Sequence=AAH52925.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH52925.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; receptor binding external side of plasma membrane cell surface membrane integral component of membrane extrathymic T cell selection regulation of immune response T cell receptor signaling pathway uc012apy.1 uc012apy.2 uc012apy.3 uc012apy.4 
ENSMUST00000080281.14 Rpl15 ENSMUST00000080281.14 ribosomal protein L15, transcript variant 3 (from RefSeq NM_025586.3) ENSMUST00000080281.1 ENSMUST00000080281.10 ENSMUST00000080281.11 ENSMUST00000080281.12 ENSMUST00000080281.13 ENSMUST00000080281.2 ENSMUST00000080281.3 ENSMUST00000080281.4 ENSMUST00000080281.5 ENSMUST00000080281.6 ENSMUST00000080281.7 ENSMUST00000080281.8 ENSMUST00000080281.9 NM_025586 Q9CWI5 Q9CZM2 RL15_MOUSE uc007shr.1 uc007shr.2 uc007shr.3 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Interacts with IFIT1 (via TPR repeats 1-4). Cytoplasm Belongs to the eukaryotic ribosomal protein eL15 family. cytoplasmic translation RNA binding structural constituent of ribosome nucleus ribosome translation membrane cytosolic large ribosomal subunit A band uc007shr.1 uc007shr.2 uc007shr.3 
ENSMUST00000080288.5 Prr19 ENSMUST00000080288.5 proline rich 19 (from RefSeq NM_001081294.1) B2RW88 ENSMUST00000080288.1 ENSMUST00000080288.2 ENSMUST00000080288.3 ENSMUST00000080288.4 NM_001081294 PRR19_MOUSE Prr19 uc009fsh.1 uc009fsh.2 uc009fsh.3 Promotes meiotic crossing over formation through its interaction with CNTD1 by participating in the crossover differentiation step of crossover-specific recombination intermediates. Interacts with CNTD1. Nucleus Chromosome Note=Co-localized at crossover sites with CNTD1 (PubMed:32555348). Localizes on synapsed chromosome only in mid/late pachytene spermatocytes (PubMed:32555348). Preferentially expressed in gonads. Mice are unfertile in both sexes. Testis weight is significantly lower. Mice males show a depletion of late prophase spermatocytes. are depleted of post-meiotic cells and their weight is significantly lower. molecular_function cellular_component biological_process uc009fsh.1 uc009fsh.2 uc009fsh.3 
ENSMUST00000080292.12 Cd6 ENSMUST00000080292.12 CD6 antigen, transcript variant 2 (from RefSeq NM_009852.3) CD6_MOUSE ENSMUST00000080292.1 ENSMUST00000080292.10 ENSMUST00000080292.11 ENSMUST00000080292.2 ENSMUST00000080292.3 ENSMUST00000080292.4 ENSMUST00000080292.5 ENSMUST00000080292.6 ENSMUST00000080292.7 ENSMUST00000080292.8 ENSMUST00000080292.9 NM_009852 Q60679 Q61003 Q61004 Q8BGK1 uc008gqy.1 uc008gqy.2 uc008gqy.3 Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram- positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS. Interacts (via extracellular domain) with ALCAM/CD166 (via extracellular domain) (PubMed:16914752). Interacts with the TCR/CD3 complex subunit CD3E. Interacts (via tyrosine phosphorylated C- terminus) with LCP2 (via SH2 domain) (PubMed:24584089). Interacts (via glycosylated extracellular domain) with LGALS1 and LGALS3. Interaction with LGALS1 or LGALS3 inhibits interaction with ALCAM (By similarity). Interacts with VAV1 (PubMed:24584089). Q61003; Q60787: Lcp2; NbExp=9; IntAct=EBI-12601992, EBI-5324248; Cell membrane ; Single-pass type I membrane protein Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells. Colocalizes with the TCR/CD3 complex at the immunological synapse. Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q61003-1; Sequence=Displayed; Name=2; IsoId=Q61003-2; Sequence=VSP_006225, VSP_006226; Name=3; IsoId=Q61003-3; Sequence=VSP_006224; Expressed predominantly in thymus, lymph node and spleen. After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues (By similarity). Phosphorylated on tyrosine residues in response to stimulation of the TCR complex (PubMed:24584089). Glycosylated. lipopolysaccharide binding immunological synapse formation immunological synapse positive regulation of protein phosphorylation acute inflammatory response to antigenic stimulus scavenger receptor activity protein binding plasma membrane endocytosis cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules membrane integral component of membrane protein kinase binding intrinsic component of plasma membrane lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide T cell receptor complex positive regulation of T cell proliferation identical protein binding spanning component of plasma membrane lipoteichoic acid binding positive regulation of cytokine production involved in inflammatory response uc008gqy.1 uc008gqy.2 uc008gqy.3 
ENSMUST00000080299.7 Yaf2 ENSMUST00000080299.7 YY1 associated factor 2, transcript variant 1 (from RefSeq NM_024189.6) ENSMUST00000080299.1 ENSMUST00000080299.2 ENSMUST00000080299.3 ENSMUST00000080299.4 ENSMUST00000080299.5 ENSMUST00000080299.6 NM_024189 Q3UFD4 Q99LW6 Q9DBE4 YAF2_MOUSE uc007xis.1 uc007xis.2 uc007xis.3 uc007xis.4 Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. Interacts with MYC, MYCN, RNF2/RING1B and YY1. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 ; Synonyms=YAF2-a ; IsoId=Q99LW6-1; Sequence=Displayed; Name=2 ; Synonyms=YAF2-b ; IsoId=Q99LW6-2; Sequence=VSP_050619, VSP_050620; In the mesoderm, expressed in the region close to the surface ectoderm. Expressed in both pre- and post-implantation embryos. transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm cytosol negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated metal ion binding uc007xis.1 uc007xis.2 uc007xis.3 uc007xis.4 
ENSMUST00000080300.9 Rps25 ENSMUST00000080300.9 ribosomal protein S25 (from RefSeq NM_024266.3) ENSMUST00000080300.1 ENSMUST00000080300.2 ENSMUST00000080300.3 ENSMUST00000080300.4 ENSMUST00000080300.5 ENSMUST00000080300.6 ENSMUST00000080300.7 ENSMUST00000080300.8 NM_024266 Q58EA6 Q58EA6_MOUSE Rps25 uc009pdn.1 uc009pdn.2 uc009pdn.3 Component of the small ribosomal subunit. Cytoplasm Belongs to the eukaryotic ribosomal protein eS25 family. ribosome uc009pdn.1 uc009pdn.2 uc009pdn.3 
ENSMUST00000080322.8 Oas1a ENSMUST00000080322.8 2'-5' oligoadenylate synthetase 1A, transcript variant 13 (from RefSeq NR_188863.1) ENSMUST00000080322.1 ENSMUST00000080322.2 ENSMUST00000080322.3 ENSMUST00000080322.4 ENSMUST00000080322.5 ENSMUST00000080322.6 ENSMUST00000080322.7 F2Z419 NR_188863 OAS1A_MOUSE Oias1 P11928 Q3UEC1 Q64440 Q91VI0 uc008zij.1 uc008zij.2 uc008zij.3 uc008zij.4 uc008zij.5 Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Reaction=3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')- adenosine + 2 diphosphate; Xref=Rhea:RHEA:34407, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:67143; EC=2.7.7.84; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is tolerated. ssRNA or dsDNA do not act as activators. Monomer (By similarity). Homotetramer (By similarity). Interacts with OAS1D; the interaction inhibits OAS1A catalytic activity (PubMed:15899864). P11928; O89168; Xeno; NbExp=5; IntAct=EBI-9352099, EBI-10107989; Cytoplasm Mitochondrion Nucleus Microsome Endoplasmic reticulum Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. Expressed in oocytes and granulosa cells of ovary, in intestine, stomach, spleen and uterus (at protein level) (PubMed:15899864). Expressed at high levels in the digestive tract and lymphoid organs (PubMed:12396720). Expressed in ovary and spleen (PubMed:27663720). Detected 5 weeks after birth in developing ovary and spleen (PubMed:27663720). Expressed in fully grown, germinal vesicle (GV)-intact oocytes, in oocytes at the metaphase II stage and in the 2- to 8-cell embryos (PubMed:15899864). Up-regulated in response to the type I interferon IFNB1, in a STAT1 and STAT2-dependent manner (PubMed:1709495, PubMed:22305621). Induced by polyinosinic:polycytidylic acid (poly I:C) (PubMed:15899864, PubMed:27663720). C-terminal prenylated. Belongs to the 2-5A synthase family. nucleotide binding 2'-5'-oligoadenylate synthetase activity immune system process RNA binding double-stranded RNA binding protein binding ATP binding nucleus nucleoplasm cytoplasm mitochondrion endoplasmic reticulum cytosol purine nucleotide biosynthetic process immune response response to virus transferase activity nucleotidyltransferase activity intracellular membrane-bounded organelle negative regulation of viral genome replication innate immune response metal ion binding negative regulation of viral process defense response to virus regulation of ribonuclease activity uc008zij.1 uc008zij.2 uc008zij.3 uc008zij.4 uc008zij.5 
ENSMUST00000080324.4 Pwwp4b ENSMUST00000080324.4 PWWP domain containing 4B (from RefSeq NM_001025384.3) DXBay18 ENSMUST00000080324.1 ENSMUST00000080324.2 ENSMUST00000080324.3 Gm14685 NM_001025384 OTTMUSG00000017677 Pwwp4a Pwwp4b Q52KH6 Q52KH6_MOUSE uc009tlg.1 uc009tlg.2 Belongs to the PWWP3A family. molecular_function cellular_component biological_process uc009tlg.1 uc009tlg.2 
ENSMUST00000080329.2 Or8g34 ENSMUST00000080329.2 olfactory receptor family 8 subfamily G member 34 (from RefSeq NM_146331.1) ENSMUST00000080329.1 NM_146331 Olfr954 Or8g34 Q9EQB6 Q9EQB6_MOUSE uc009oxy.1 uc009oxy.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oxy.1 uc009oxy.2 
ENSMUST00000080333.8 Cfap299 ENSMUST00000080333.8 cilia and flagella associated protein 299, transcript variant 2 (from RefSeq NM_001417875.1) CF299_MOUSE Cfap299 ENSMUST00000080333.1 ENSMUST00000080333.2 ENSMUST00000080333.3 ENSMUST00000080333.4 ENSMUST00000080333.5 ENSMUST00000080333.6 ENSMUST00000080333.7 NM_001417875 Q810M1 uc008yge.1 uc008yge.2 May be involved in spermatogenesis. Cytoplasm Nucleus Note=Mainly cytoplasmic. Abundantly expressed in testis, specifically in spermatogonia and primary spermatocytes but not in secondary spermatocytes and spermatids. First detected in testis in two week old mice; expression continuously increases in testis from 2 to 8 weeks after birth and remains at a constant level in 6-month-old testis. molecular_function nucleus cytoplasm biological_process uc008yge.1 uc008yge.2 
ENSMUST00000080335.11 Col25a1 ENSMUST00000080335.11 collagen, type XXV, alpha 1, transcript variant 1 (from RefSeq NM_029838.4) COPA1_MOUSE Col25a1 ENSMUST00000080335.1 ENSMUST00000080335.10 ENSMUST00000080335.2 ENSMUST00000080335.3 ENSMUST00000080335.4 ENSMUST00000080335.5 ENSMUST00000080335.6 ENSMUST00000080335.7 ENSMUST00000080335.8 ENSMUST00000080335.9 G3X9H6 NM_029838 Q99MQ5 uc033hzv.1 uc033hzv.2 uc033hzv.3 Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (By similarity). Forms homodimers and homotrimers. Binds to the fibrillized forms of amyloid-beta protein 40 (beta-APP40) and amyloid-betad protein 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40 (By similarity). Membrane ; Single-pass type II membrane protein Note=After proteolytic cleavage, CLAC is secreted. Expressed predominantly in neurons with low levels also detected in heart, testis and eye. Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component. Glycosylated. Hydroxylated on proline and lysine residues. beta-amyloid binding extracellular region collagen trimer extracellular space integral component of plasma membrane heparin binding membrane integral component of membrane extracellular matrix structural constituent conferring tensile strength identical protein binding axonogenesis involved in innervation uc033hzv.1 uc033hzv.2 uc033hzv.3 
ENSMUST00000080348.12 Zfp551 ENSMUST00000080348.12 zinc finger protein 551 (from RefSeq NM_001033820.3) B2RUI1 ENSMUST00000080348.1 ENSMUST00000080348.10 ENSMUST00000080348.11 ENSMUST00000080348.2 ENSMUST00000080348.3 ENSMUST00000080348.4 ENSMUST00000080348.5 ENSMUST00000080348.6 ENSMUST00000080348.7 ENSMUST00000080348.8 ENSMUST00000080348.9 NM_001033820 Q3UVG7 ZN551_MOUSE Znf551 uc009fea.1 uc009fea.2 uc009fea.3 uc009fea.4 uc009fea.5 uc009fea.6 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding nucleus regulation of transcription, DNA-templated metal ion binding uc009fea.1 uc009fea.2 uc009fea.3 uc009fea.4 uc009fea.5 uc009fea.6 
ENSMUST00000080353.3 Ing2 ENSMUST00000080353.3 inhibitor of growth family, member 2 (from RefSeq NM_023503.3) ENSMUST00000080353.1 ENSMUST00000080353.2 ING2_MOUSE Ing1l NM_023503 Q4VAD7 Q80VI5 Q8BGU8 Q9ESK4 uc009lrf.1 uc009lrf.2 uc009lrf.3 uc009lrf.4 Seems to be involved in p53/TP53 activation and p53/TP53- dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity). Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2. Nucleus Note=Predominantly cytoplasmic. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm (By similarity). The PHD-type zinc finger mediates the binding to H3K4me3. The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5- phosphate (PtdIns(5)P). Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. Belongs to the ING family. Sequence=AAH50003.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; DNA binding chromatin binding nucleus nucleoplasm Golgi apparatus cytosol plasma membrane chromatin organization regulation of transcription, DNA-templated male meiosis I spermatogenesis spermatid development negative regulation of cell proliferation Sin3 complex CCAAT-binding factor complex flagellated sperm motility positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of histone deacetylation methylated histone binding phosphatidylinositol binding regulation of growth regulation of apoptotic process macromolecular complex binding positive regulation of transcription, DNA-templated metal ion binding male germ-line stem cell asymmetric division seminiferous tubule development regulation of cellular senescence negative regulation of apoptotic signaling pathway uc009lrf.1 uc009lrf.2 uc009lrf.3 uc009lrf.4 
ENSMUST00000080356.10 Snrpa ENSMUST00000080356.10 small nuclear ribonucleoprotein polypeptide A, transcript variant 1 (from RefSeq NM_015782.3) ENSMUST00000080356.1 ENSMUST00000080356.2 ENSMUST00000080356.3 ENSMUST00000080356.4 ENSMUST00000080356.5 ENSMUST00000080356.6 ENSMUST00000080356.7 ENSMUST00000080356.8 ENSMUST00000080356.9 NM_015782 Q52LA2 Q62189 Rnu1a-1 SNRPA_MOUSE uc009fvi.1 uc009fvi.2 uc009fvi.3 Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity). U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SFPQ; component of a snRNP- free complex with SFPQ (By similarity). Nucleus Belongs to the RRM U1 A/B'' family. mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus nucleoplasm spliceosomal complex U1 snRNP mRNA processing RNA splicing U1 snRNA binding identical protein binding regulation of mRNA polyadenylation U1 snRNP binding uc009fvi.1 uc009fvi.2 uc009fvi.3 
ENSMUST00000080359.12 Rest ENSMUST00000080359.12 RE1-silencing transcription factor (from RefSeq NM_011263.2) A0JNY8 ENSMUST00000080359.1 ENSMUST00000080359.10 ENSMUST00000080359.11 ENSMUST00000080359.2 ENSMUST00000080359.3 ENSMUST00000080359.4 ENSMUST00000080359.5 ENSMUST00000080359.6 ENSMUST00000080359.7 ENSMUST00000080359.8 ENSMUST00000080359.9 NM_011263 Nrsf Q155C6 Q3U0W0 Q4VAD6 Q8VIG1 Q9CW43 REST_MOUSE uc008xvz.1 uc008xvz.2 uc008xvz.3 uc008xvz.4 Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:29961578, PubMed:9771705). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (By similarity). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (By similarity). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 2 (PubMed:21884984). Repressor activity may be inhibited by forming heterodimers with isoform 2, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:10490617, PubMed:11039732). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (PubMed:15907476). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:27819263). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (PubMed:25727884). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (By similarity). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). [Isoform 2]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than isoform 1 (PubMed:11039732). Exhibits weaker repressor activity compared to isoform 1 (By similarity). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11039732, PubMed:10490617). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif- containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (By similarity). Post- transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 2 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes, maintenance of hair cells and hearing (PubMed:29961578). Isoform 1 and isoform 2 form heterodimers (PubMed:10490617). Isoform 2: Forms homodimers and homooligomers; binds to the neuron- restrictive silencer element (NRSE) as monomer (PubMed:11039732). Interacts with SIN3A, SIN3B and RCOR1 (By similarity). Interacts with CDYL (By similarity). Interacts with EHMT1 and EHMT2 only in the presence of CDYL (By similarity). Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2 (By similarity). Interacts (via zinc-finger DNA-binding domain) with ZFP90 (via N- and C-termini); the interaction inhibits REST repressor activity (PubMed:21284946). Interacts (via C2H2-type zinc finger 5) with PRICKLE1 (By similarity). Interacts with FBXW11 and BTRC (By similarity). Interacts with USP7 (By similarity). Q8VIG1; Q3U5C7: Prickle1; NbExp=2; IntAct=EBI-2312802, EBI-27099745; Q8VIG1; Q96MT3: PRICKLE1; Xeno; NbExp=4; IntAct=EBI-2312802, EBI-2348662; Nucleus toplasm Note=Colocalizes with ZFP90 in the nucleus (PubMed:21284946). In response to hypoxia, there is a more pronounced increase in levels in the nucleus as compared to the cytoplasm (By similarity). In aging neurons, increased levels in the nucleus as compared to the cytoplasm (By similarity). [Isoform 2]: Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VIG1-1; Sequence=Displayed; Name=2; Synonyms=N16, REST4; IsoId=Q8VIG1-2; Sequence=VSP_022069, VSP_022071; Name=3; Synonyms=N28; IsoId=Q8VIG1-3; Sequence=VSP_022070, VSP_022072; Expressed in the hippocampus, including quiescent neuronal progenitor (QNP) cells, transient-amplifying progenitor (TAP) cells, neuroblasts and mature neurons (at protein level) (PubMed:27819263). Expressed in embryonic stem cells (at protein level) (PubMed:15907476). Expressed in many non-neuronal tissues including the heart and liver (PubMed:7871435). Abundantly expressed in osteoblastic lineage cells (PubMed:25727884). Expressed in the spleen, kidney, blood cells, cortex, neocortex and in the utricle, saccule and organ of Corti of the inner ear (PubMed:29961578). Isoform 2: Expressed in the cortex, neocortex and in the utricle, saccule and organ of Corti of the inner ear (PubMed:29961578). Ubiquitously expressed in 8.5 dpc and 9.5 dpc embryos (PubMed:9771705). During embryogenesis, expressed at high levels in non-neuronal and differentiated peripheral nervous tissues, but is not expressed in differentiating neurons in the CNS (PubMed:7697725, PubMed:7871435). Expressed in the neocortex at embryonic stage 14.5 dpc and 16 dpc and in the utricle at 15.5 dpc (PubMed:29961578). Isoform 2: Expressed in the neocortex at embryonic stage 14.5 dpc and 16 dpc and in the utricle and saccule at 16 dpc (PubMed:29961578). Down-regulated in differentiating neurons and mature neurons. The C2H2-type zinc finger 5 is required for nuclear localization. O-glycosylated. Phosphorylated; phosphorylation is required for ubiquitination. Ubiquitinated; ubiquitination is mediated by BTRC and leads to proteasomal degradation in G2 phase (By similarity). Ubiquitination increases during neuronal differentiation (By similarity). Deubiquitinated by USP7; leading to its stabilization and promoting the maintenance of neural progenitor cells (By similarity). Embryonic lethality by embryonic day 11.5 dpc (PubMed:9771705). At 9.25 dpc, disorganization of the head mesenchyme in the midbrain region with separation of myotomal cells from the dermomyotome and widespread apoptotic cell death (PubMed:9771705). Forebrain malformation and widening of the mesencephalic flexure at 9.5 dpc and 10.5 dpc, and growth retardation by 10.5 dpc (PubMed:9771705). Conditional knockout in the nervous system results in a progressive age-related neurodegenerative phenotype (PubMed:24670762). At the age of 1 month, no change of neuronal numbers in the cortex and hippocampus, but at the age of 8 months, neuronal degeneration and apoptosis, accompanied by significant neuronal loss in the cerebral cortex and hippocampus, and pronounced gliosis (PubMed:24670762). In primary 16 dpc cortical neurons, increased degeneration and cell death upon oxidative stress or exposure to oligomeric amyloid-beta 42 (PubMed:24670762). Conditional knockout in QNP cells leads to a higher number of proliferating QNP cells, an increased transition to TAP cells and increased differentiation into mature neurons (PubMed:27819263). Conditional knockdout in proliferating cells leads to a decreased number of proliferating TAP cells and an increase in immature and mature neurons (PubMed:27819263). [Isoform 2]: Produced by SRRM4-dependent alternative splicing in neurons and inner ear hair cells (PubMed:11039732, PubMed:29961578). Lacks the four C-terminal zinc fingers and the RCOR1 corepressor interaction site found in full length REST isoform 1, which are required for full DNA-binding and repressive activity (PubMed:11039732, PubMed:29961578). [Isoform 2]: Controversial data exists concerning the repressor activity of isoform 2. A study in human showed that human isoform 3 exhibits weak repressor activity of a NRSE motif-containing reporter construct (By similarity). Another report, however, does not observe any isoform 3 transcriptional repressor activity of a NRSE motif-containing reporter construct (By similarity). Controversial data also exists regarding the function of isoform 2 on the negative regulation of full-length REST. It was shown that isoform 2 negatively regulates the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:10490617, PubMed:11039732). Another study in human, however, did not observe any inhibitory activity of human isoform 3 on the isoform 1 repressor activity (By similarity). Sequence=AAH96434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; negative regulation of transcription from RNA polymerase II promoter regulation of alternative mRNA splicing, via spliceosome chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding response to hypoxia hematopoietic progenitor cell differentiation response to ischemia nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription factor binding negative regulation of cell proliferation regulation of gene expression positive regulation of gene expression negative regulation of gene expression transcriptional repressor complex negative regulation of aldosterone biosynthetic process macromolecular complex somatic stem cell population maintenance cellular response to drug protein homodimerization activity positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process sequence-specific DNA binding negative regulation by host of viral transcription transcription regulatory region DNA binding macromolecular complex binding negative regulation of neuron differentiation positive regulation of neuron differentiation regulation of osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of calcium ion-dependent exocytosis negative regulation of insulin secretion metal ion binding negative regulation of neurogenesis neuromuscular process controlling balance detection of mechanical stimulus involved in sensory perception of sound protein homooligomerization auditory receptor cell stereocilium organization cardiac muscle cell myoblast differentiation histone H4 deacetylation cellular response to electrical stimulus cellular response to glucocorticoid stimulus neuronal stem cell population maintenance modification of synaptic structure positive regulation of stem cell population maintenance regulation of oxidative stress-induced neuron death negative regulation of oxidative stress-induced neuron death positive regulation of oxidative stress-induced neuron death negative regulation of cortisol biosynthetic process negative regulation of transcription regulatory region DNA binding negative regulation of dense core granule biogenesis negative regulation of mesenchymal stem cell differentiation negative regulation of amniotic stem cell differentiation histone methyltransferase complex uc008xvz.1 uc008xvz.2 uc008xvz.3 uc008xvz.4 
ENSMUST00000080361.13 Akr1c20 ENSMUST00000080361.13 aldo-keto reductase family 1, member C20 (from RefSeq NM_001311132.1) Akr1c20 ENSMUST00000080361.1 ENSMUST00000080361.10 ENSMUST00000080361.11 ENSMUST00000080361.12 ENSMUST00000080361.2 ENSMUST00000080361.3 ENSMUST00000080361.4 ENSMUST00000080361.5 ENSMUST00000080361.6 ENSMUST00000080361.7 ENSMUST00000080361.8 ENSMUST00000080361.9 NM_001311132 Q8VC77 Q8VC77_MOUSE uc007pjp.1 uc007pjp.2 uc007pjp.3 uc007pjp.4 Belongs to the aldo/keto reductase family. alditol:NADP+ 1-oxidoreductase activity aldo-keto reductase (NADP) activity cytosol prostaglandin metabolic process steroid biosynthetic process alcohol dehydrogenase (NADP+) activity steroid metabolic process steroid dehydrogenase activity oxidoreductase activity bile acid binding progesterone metabolic process daunorubicin metabolic process doxorubicin metabolic process androsterone dehydrogenase activity ketosteroid monooxygenase activity oxidation-reduction process uc007pjp.1 uc007pjp.2 uc007pjp.3 uc007pjp.4 
ENSMUST00000080368.13 Atp8a2 ENSMUST00000080368.13 ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 (from RefSeq NM_015803.3) AT8A2_MOUSE Atp8a2 B2RQF2 ENSMUST00000080368.1 ENSMUST00000080368.10 ENSMUST00000080368.11 ENSMUST00000080368.12 ENSMUST00000080368.2 ENSMUST00000080368.3 ENSMUST00000080368.4 ENSMUST00000080368.5 ENSMUST00000080368.6 ENSMUST00000080368.7 ENSMUST00000080368.8 ENSMUST00000080368.9 NM_015803 P98200 uc007uet.1 uc007uet.2 uc007uet.3 Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:22912588). Able to translocate phosphatidylserine, but not phosphatidylcholine (By similarity). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:22912588). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (By similarity). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth (PubMed:22641037). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival (PubMed:24413176). Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38567, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57262, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38568; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:36439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:64612, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36440; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit. Interacts with TMEM30A to form a flippase complex. Membrane ; Multi- pass membrane protein Golgi apparatus membrane Endosome membrane Cell membrane Photoreceptor outer segment membrane Photoreceptor inner segment membrane Note=Localizes to the Golgi and endosomes in photoreceptor cells (PubMed:24413176). Localizes to disk membranes of rod photoreceptor outer segments (ROS) (By similarity). Found in testis, heart and brain. Most abundant in testis. Also detected in fetal tissues. Expressed in retinal photoreceptor cells; detected in retina outer nuclear layer and inner segment (at protein level). Note=Defects in Atp8a2 are the cause of Wabbler-lethal (wl) phenotype. Homozygotes show severe neurological annormalities that include ataxia and body tremors linked to progressive axonal degeneration in several areas of the nervous system. Atp8a2 and Atp8a1 double mutant mice die soon after birth. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. nucleotide binding magnesium ion binding photoreceptor outer segment involuntary skeletal muscle contraction ATP binding nucleoplasm endosome Golgi apparatus trans-Golgi network plasma membrane lipid transport axonogenesis aging retina layer formation positive regulation of neuron projection development response to auditory stimulus aminophospholipid transporter activity phospholipid transport membrane integral component of membrane neuron projection development positive regulation of multicellular organism growth inner ear morphogenesis eating behavior cell projection skin development phospholipid translocation metal ion binding neuron development neuromuscular process controlling posture detection of light stimulus involved in visual perception neurofilament cytoskeleton organization positive regulation of phospholipid translocation uc007uet.1 uc007uet.2 uc007uet.3 
ENSMUST00000080371.8 Mtss1 ENSMUST00000080371.8 MTSS I-BAR domain containing 1, transcript variant 1 (from RefSeq NM_144800.3) ENSMUST00000080371.1 ENSMUST00000080371.2 ENSMUST00000080371.3 ENSMUST00000080371.4 ENSMUST00000080371.5 ENSMUST00000080371.6 ENSMUST00000080371.7 G3X9H7 G3X9H7_MOUSE Mtss1 NM_144800 uc007vty.1 uc007vty.2 uc007vty.3 uc007vty.4 actin binding actin monomer binding receptor binding plasma membrane organization actin cytoskeleton actin cytoskeleton organization identical protein binding uc007vty.1 uc007vty.2 uc007vty.3 uc007vty.4 
ENSMUST00000080403.7 Magel2 ENSMUST00000080403.7 MAGE family member L2 (from RefSeq NM_013779.2) ENSMUST00000080403.1 ENSMUST00000080403.2 ENSMUST00000080403.3 ENSMUST00000080403.4 ENSMUST00000080403.5 ENSMUST00000080403.6 F8WIA8 MAGL2_MOUSE NM_013779 Q9QZ04 uc009hfh.1 uc009hfh.2 uc009hfh.3 uc009hfh.4 Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (PubMed:22208286). Part of a complex consisting of MAGEL2, TRIM27 and USP7; directly interacts with USP7 (By similarity). Interacts with TRIM27. Interacts with VPS35; leading to recruitment at retromer-containing endosomes (By similarity). Interacts with BMAL1 and PER2. Early endosome. Cytoplasm Nucleus Note=Recruited to retromer-containing endosomes via interaction with VPS35. Colocalizes with CLOCK and BMAL1 in the cytoplasm, and with PER2 in the cytoplasm and nucleus. Expressed predominantly in late development stages and adult brain. Deficient mice show reduced embryonic viability, neonatal growth retardation, excessive weight gain after weaning, and increased adiposity with altered metabolism, including increased fasting insulin and elevated cholesterol, in adulthood. Mutant mice also show abnormalities in the circadian pattern of feeding behavior. Deficient mice show features similar to those of Prader-Willi syndrome in humans. Sequence=AAH54763.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAB62395.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ubiquitin-protein transferase activity protein binding nucleus cytoplasm endosome early endosome cytosol retromer complex Arp2/3 complex-mediated actin nucleation retrograde transport, endosome to Golgi regulation of circadian rhythm negative regulation of transcription, DNA-templated rhythmic process positive regulation of actin nucleation protein K63-linked ubiquitination uc009hfh.1 uc009hfh.2 uc009hfh.3 uc009hfh.4 
ENSMUST00000080406.7 Zfp251 ENSMUST00000080406.7 zinc finger protein 251 (from RefSeq NM_001007568.2) ENSMUST00000080406.1 ENSMUST00000080406.2 ENSMUST00000080406.3 ENSMUST00000080406.4 ENSMUST00000080406.5 ENSMUST00000080406.6 NM_001007568 Q6PCX8 Q6PCX8_MOUSE Zfp251 uc007wmm.1 uc007wmm.2 uc007wmm.3 uc007wmm.4 uc007wmm.5 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc007wmm.1 uc007wmm.2 uc007wmm.3 uc007wmm.4 uc007wmm.5 
ENSMUST00000080407.6 Zfp735 ENSMUST00000080407.6 zinc finger protein 735 (from RefSeq NM_001126489.2) B1ARH2 B1ARH2_MOUSE ENSMUST00000080407.1 ENSMUST00000080407.2 ENSMUST00000080407.3 ENSMUST00000080407.4 ENSMUST00000080407.5 NM_001126489 Zfp735 uc007kaz.1 uc007kaz.2 uc007kaz.3 uc007kaz.4 transcription regulatory region sequence-specific DNA binding nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated biological_process metal ion binding uc007kaz.1 uc007kaz.2 uc007kaz.3 uc007kaz.4 
ENSMUST00000080428.13 Opn1sw ENSMUST00000080428.13 opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) (from RefSeq NM_007538.3) Bcp ENSMUST00000080428.1 ENSMUST00000080428.10 ENSMUST00000080428.11 ENSMUST00000080428.12 ENSMUST00000080428.2 ENSMUST00000080428.3 ENSMUST00000080428.4 ENSMUST00000080428.5 ENSMUST00000080428.6 ENSMUST00000080428.7 ENSMUST00000080428.8 ENSMUST00000080428.9 NM_007538 OPSB_MOUSE P51491 Q548Z8 uc009bdi.1 uc009bdi.2 uc009bdi.3 Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (PubMed:21219924, PubMed:25416279). Involved in ensuring correct abundance and localization of retinal membrane proteins (PubMed:25416279). May increase spectral sensitivity in dim light (PubMed:11055434). Cell membrane ; Multi-pass membrane protein Photoreceptor inner segment Cell projection, cilium, photoreceptor outer segment Cytoplasm, perinuclear region Expressed in the inner and outer segments of cone photoreceptor cells in the retina (at protein level). Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. Knockout mice are viable with normal gross morphology (PubMed:21219924). Cone photoreceptors are normal and provide a normal flash response, however cone cells in the ventral retina have thin or undetectable outer segments that exhibit mild to severe disordered organization (PubMed:21219924, PubMed:25416279). Cone cells show increased sensitivity to mid-wavelength light, potentially as result of increased protein Opn1mw abundance (PubMed:21219924). Lrat and Opn1sw double knockout mice show no change in cone cell viability in the central and ventral retina, however show shorter and swollen outer and inner segments at twelve months of age (PubMed:25416279). Double knockout of Lrat and Opn1sw results in a reduction in the slow degeneration of dorsal cone photoreceptors compared to Lrat knockout mice (PubMed:25416279). Lrat and Opn1sw double knockout mice show a reduced abundance of transmembrane and peripheral membrane-associated proteins in cone inner and outer segments (PubMed:25416279). Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. photoreceptor outer segment photoreceptor inner segment G-protein coupled receptor activity integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway visual perception phototransduction G-protein coupled photoreceptor activity detection of visible light photoreceptor activity membrane integral component of membrane protein-chromophore linkage cell projection terminal bouton cell body response to stimulus cellular response to light stimulus uc009bdi.1 uc009bdi.2 uc009bdi.3 
ENSMUST00000080431.8 Slc5a6 ENSMUST00000080431.8 solute carrier family 5 (sodium-dependent vitamin transporter), member 6, transcript variant 3 (from RefSeq NM_001177622.1) ENSMUST00000080431.1 ENSMUST00000080431.2 ENSMUST00000080431.3 ENSMUST00000080431.4 ENSMUST00000080431.5 ENSMUST00000080431.6 ENSMUST00000080431.7 NM_001177622 Q5U4D8 Q8BTU3 SC5A6_MOUSE Slc5a6 uc008wwv.1 uc008wwv.2 Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:23104561). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (By similarity). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:23104561). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (PubMed:27492331). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (By similarity). Reaction=biotin(out) + 2 Na(+)(out) = biotin(in) + 2 Na(+)(in); Xref=Rhea:RHEA:73375, ChEBI:CHEBI:29101, ChEBI:CHEBI:57586; Evidence=; Reaction=(R)-pantothenate(out) + 2 Na(+)(out) = (R)-pantothenate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:73371, ChEBI:CHEBI:29032, ChEBI:CHEBI:29101; Evidence=; Reaction=(R)-lipoate(out) + 2 Na(+)(out) = (R)-lipoate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:73379, ChEBI:CHEBI:29101, ChEBI:CHEBI:83088; Evidence=; Reaction=iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71207, ChEBI:CHEBI:16382, ChEBI:CHEBI:29101; Evidence=; Interacts with PDZD11. Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Expressed in the intestinal mucosa, liver and kidney (at protein level) (PubMed:23104561). Expressed in the colon (PubMed:28052864). The C-terminal tail is important for biotin uptake as well as apical localization in polarized cells. Intestine-specific knockout leads to premature lethality between the age of 6 and 10 weeks in around two-thirds of mice due to acute peritonitis (PubMed:23104561). Growth retardation, decreased bone density of the femoral and humoral head, decreased bone length of the pelvic, tibial, and femoral bones, lethargic behavior, hunched back posture, and decreased biotin status are observed (PubMed:23104561). Abnormalities in the small bowel with shortened villi and dysplasia, chronic active inflammation with focal cryptitis/crypt abscesses in the cecum, an increase in the number of neutrophils in the mucosa and low-grade adenomatous changes and extensive submucosal edema (PubMed:23104561). Impaired carrier-mediated biotin and pantothenate uptake in the jejunum (PubMed:23104561). Reduced biotin levels in the liver (PubMed:23104561). Increase in gut permeability and changes in the level of expression of tight junction proteins in the cecum and colon (PubMed:27492331). Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. ion transport sodium ion transport sodium-dependent multivitamin transmembrane transporter activity vesicle membrane symporter activity biotin transport pantothenate transmembrane transport membrane integral component of membrane transmembrane transporter activity brush border membrane transmembrane transport uc008wwv.1 uc008wwv.2 
ENSMUST00000080437.13 Dennd5a ENSMUST00000080437.13 DENN domain containing 5A, transcript variant 1 (from RefSeq NM_021494.1) DEN5A_MOUSE ENSMUST00000080437.1 ENSMUST00000080437.10 ENSMUST00000080437.11 ENSMUST00000080437.12 ENSMUST00000080437.2 ENSMUST00000080437.3 ENSMUST00000080437.4 ENSMUST00000080437.5 ENSMUST00000080437.6 ENSMUST00000080437.7 ENSMUST00000080437.8 ENSMUST00000080437.9 NM_021494 Q62146 Q6PAL8 Q8C829 Q8VDF6 Q9QYZ2 Rab6ip1 uc009jek.1 uc009jek.2 uc009jek.3 uc009jek.4 Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth (By similarity). Interacts with RAB6A bound to GTP. Q6PAL8; P20340-1: RAB6A; Xeno; NbExp=4; IntAct=EBI-15750630, EBI-8851226; Golgi apparatus membrane Belongs to the RAB6IP1 family. Golgi membrane guanyl-nucleotide exchange factor activity protein binding Golgi apparatus trans-Golgi network cytosol negative regulation of neuron projection development membrane Rab guanyl-nucleotide exchange factor activity Rab GTPase binding retromer complex retrograde transport, endosome to Golgi uc009jek.1 uc009jek.2 uc009jek.3 uc009jek.4 
ENSMUST00000080449.7 Hspa2 ENSMUST00000080449.7 heat shock protein 2, transcript variant 3 (from RefSeq NM_001409571.1) ENSMUST00000080449.1 ENSMUST00000080449.2 ENSMUST00000080449.3 ENSMUST00000080449.4 ENSMUST00000080449.5 ENSMUST00000080449.6 HSP72_MOUSE Hcp70.2 Hsp70-2 NM_001409571 P17156 Q99KD7 uc007nyf.1 uc007nyf.2 uc007nyf.3 Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (By similarity). Plays a role in spermatogenesis (PubMed:24557841). In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (PubMed:24557841). Interacts with FKBP6 (By similarity). Interacts with ZNF541 (PubMed:18849567). Component of the CatSper complex (PubMed:21224844). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (PubMed:23055941). Interacts with SHCBP1L; this interaction may promote the recruitment of HSPA2 to the spindle (PubMed:24557841). Interacts with MOV10L1 (PubMed:20547853). Cytoplasm, cytoskeleton, spindle Note=Colocalizes with SHCBP1L at spindle during the meiosis process (PubMed:24557841). Expressed in male germ cells (at protein level) (PubMed:24557841, PubMed:23055941, PubMed:3405224). Specifically expressed in prophage stage of meiosis (PubMed:3405224). The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide- binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins. Belongs to the heat shock protein 70 family. nucleotide binding synaptonemal complex male germ cell nucleus positive regulation of protein phosphorylation protein binding ATP binding nucleus nucleoplasm cytoplasm mitochondrion spindle cytosol cytoskeleton plasma membrane response to unfolded protein male meiosis male meiosis I spermatogenesis spermatid development response to heat response to cold cell surface positive regulation of G2/M transition of mitotic cell cycle vesicle-mediated transport ATPase activity enzyme binding cell differentiation heat shock protein binding positive regulation of ATPase activity cellular response to heat cellular response to unfolded protein CatSper complex protein refolding ATPase activity, coupled myelin sheath protein binding involved in protein folding tau protein binding unfolded protein binding chaperone mediated protein folding requiring cofactor chaperone binding misfolded protein binding glycolipid binding synaptonemal complex disassembly meiotic spindle negative regulation of inclusion body assembly disordered domain specific binding positive regulation of calcium-transporting ATPase activity uc007nyf.1 uc007nyf.2 uc007nyf.3 
ENSMUST00000080453.8 Tbpl2 ENSMUST00000080453.8 TATA box binding protein like 2, transcript variant 3 (from RefSeq NR_110359.1) A2AQK6 ENSMUST00000080453.1 ENSMUST00000080453.2 ENSMUST00000080453.3 ENSMUST00000080453.4 ENSMUST00000080453.5 ENSMUST00000080453.6 ENSMUST00000080453.7 NR_110359 Q498A1 Q6SJ95 TBPL2_MOUSE Tbp2 Tbpl2 Trf3 uc008iol.1 uc008iol.2 uc008iol.3 uc008iol.4 Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. Interacts with TAF3. Q6SJ95; Q5HZG4: Taf3; NbExp=3; IntAct=EBI-1571412, EBI-1561080; Cytoplasm cleus te=Present in the cytoplasm during cytokinesis. Expressed in myotubes and myofibers (at protein level). Expressed in a wide variety of tissues with highest levels in heart, lung, liver, uterus and placenta and especially the gonads. Expression is higher in the ovary than the testis, and within the ovary expression is localized to the oocytes. Belongs to the TBP family. transcription factor TFIIIB complex RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase III regulatory region DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex transcription factor TFIID complex cytoplasm DNA-templated transcription, initiation transcription from RNA polymerase II promoter multicellular organism development transcription factor binding negative regulation of transcription, DNA-templated RNA polymerase III transcriptional preinitiation complex assembly uc008iol.1 uc008iol.2 uc008iol.3 uc008iol.4 
ENSMUST00000080492.7 Rpl36 ENSMUST00000080492.7 ribosomal protein L36 (from RefSeq NM_018730.3) ENSMUST00000080492.1 ENSMUST00000080492.2 ENSMUST00000080492.3 ENSMUST00000080492.4 ENSMUST00000080492.5 ENSMUST00000080492.6 NM_018730 P47964 Q6ZWZ4 RL36_MOUSE uc008dcn.1 uc008dcn.2 uc008dcn.3 uc008dcn.4 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Cytoplasm, cytosol Cytoplasm Note=Detected on cytosolic polysomes. Belongs to the eukaryotic ribosomal protein eL36 family. cytoplasmic translation structural constituent of ribosome cytoplasm cytosol ribosome translation cytosolic large ribosomal subunit synapse uc008dcn.1 uc008dcn.2 uc008dcn.3 uc008dcn.4 
ENSMUST00000080511.3 H1f5 ENSMUST00000080511.3 H1.5 linker histone, cluster member (from RefSeq NM_020034.2) ENSMUST00000080511.1 ENSMUST00000080511.2 H1-5 H15_MOUSE Hist1h1b NM_020034 P43276 Q9CRM8 uc007pri.1 uc007pri.2 uc007pri.3 uc007pri.4 Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Sep 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Interacts with MSX1. P43276; P13297: Msx1; NbExp=3; IntAct=EBI-903960, EBI-903969; Nucleus Chromosome Note=Mainly localizes with heterochromatin (By similarity). Associates with actively transcribed chromatin and not heterochromatin (By similarity). The C-terminal domain is required for high-affinity binding to chromatin. H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Hydroxybutyrylation of histones is induced by starvation. Belongs to the histone H1/H5 family. negative regulation of transcription from RNA polymerase II promoter nucleosome nuclear chromatin DNA binding double-stranded DNA binding protein binding nucleus chromosome nuclear euchromatin nuclear heterochromatin chromatin organization nucleosome assembly regulation of transcription, DNA-templated muscle organ development nucleosome positioning chromosome condensation positive regulation of cell growth chromatin DNA binding nucleosomal DNA binding negative regulation of chromatin silencing histone deacetylase binding negative regulation of DNA recombination protein stabilization positive regulation of histone H3-K9 methylation establishment of protein localization to chromatin uc007pri.1 uc007pri.2 uc007pri.3 uc007pri.4 
ENSMUST00000080514.9 Rpp25 ENSMUST00000080514.9 ribonuclease P/MRP 25 subunit (from RefSeq NM_133982.1) ENSMUST00000080514.1 ENSMUST00000080514.2 ENSMUST00000080514.3 ENSMUST00000080514.4 ENSMUST00000080514.5 ENSMUST00000080514.6 ENSMUST00000080514.7 ENSMUST00000080514.8 NM_133982 Q91WE3 RPP25_MOUSE uc009puy.1 uc009puy.2 uc009puy.3 Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA. Nucleus, nucleolus Belongs to the histone-like Alba family. ribonuclease MRP complex tRNA 5'-leader removal nucleic acid binding RNA binding ribonuclease P activity nucleus nucleoplasm nucleolus microtubule organizing center rRNA processing tRNA processing hydrolase activity multimeric ribonuclease P complex ribonuclease P RNA binding RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc009puy.1 uc009puy.2 uc009puy.3 
ENSMUST00000080517.14 Cfap418 ENSMUST00000080517.14 cilia and flagella associated protein 418 (from RefSeq NM_026005.3) CF418_MOUSE Cfap418 ENSMUST00000080517.1 ENSMUST00000080517.10 ENSMUST00000080517.11 ENSMUST00000080517.12 ENSMUST00000080517.13 ENSMUST00000080517.2 ENSMUST00000080517.3 ENSMUST00000080517.4 ENSMUST00000080517.5 ENSMUST00000080517.6 ENSMUST00000080517.7 ENSMUST00000080517.8 ENSMUST00000080517.9 NM_026005 Q3UJP5 Q6PDD5 uc012dam.1 uc012dam.2 uc012dam.3 uc012dam.4 May be involved in photoreceptor outer segment disk morphogenesis. Interacts (via N-terminus) with FAM161A (via central region); the interaction is direct. Cytoplasm otoreceptor inner segment Note=In the retina, located at the base of the primary cilium (PubMed:22177090). Expressed throughout photoreceptors cell body including the basal body, inner segment and synaptic terminus, but not in the outer segment (at the protein level). Expressed in multiple tissues, including the brain, kidney, lung, spleen, heart, trachea and testis (PubMed:29440555). Expressed in the retina (at protein level) (PubMed:22177090, PubMed:29440555). No visible phenotype. However mice exhibit progressive and simultaneous degeneration of rod and cone photoreceptors (PubMed:29440555). photoreceptor inner segment molecular_function cytoplasm cytosol plasma membrane photoreceptor cell morphogenesis cell junction ciliary base uc012dam.1 uc012dam.2 uc012dam.3 uc012dam.4 
ENSMUST00000080518.14 Sbsn ENSMUST00000080518.14 suprabasin, transcript variant 1 (from RefSeq NM_172205.3) E9QPB2 E9QPB2_MOUSE ENSMUST00000080518.1 ENSMUST00000080518.10 ENSMUST00000080518.11 ENSMUST00000080518.12 ENSMUST00000080518.13 ENSMUST00000080518.2 ENSMUST00000080518.3 ENSMUST00000080518.4 ENSMUST00000080518.5 ENSMUST00000080518.6 ENSMUST00000080518.7 ENSMUST00000080518.8 ENSMUST00000080518.9 NM_172205 Sbsn uc009ggg.1 uc009ggg.2 uc009ggg.3 uc009ggg.1 uc009ggg.2 uc009ggg.3 
ENSMUST00000080533.6 Defa24 ENSMUST00000080533.6 defensin, alpha, 24 (from RefSeq NM_001024225.2) DFA24_MOUSE Defcr24 ENSMUST00000080533.1 ENSMUST00000080533.2 ENSMUST00000080533.3 ENSMUST00000080533.4 ENSMUST00000080533.5 NM_001024225 Q5G865 uc009lbx.1 uc009lbx.2 uc009lbx.3 May have microbicidal activities. Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc009lbx.1 uc009lbx.2 uc009lbx.3 
ENSMUST00000080536.8 Abce1 ENSMUST00000080536.8 ATP-binding cassette, sub-family E member 1, transcript variant 2 (from RefSeq NR_152614.1) Abce1 ENSMUST00000080536.1 ENSMUST00000080536.2 ENSMUST00000080536.3 ENSMUST00000080536.4 ENSMUST00000080536.5 ENSMUST00000080536.6 ENSMUST00000080536.7 NR_152614 Q3UHY8 Q3UHY8_MOUSE uc009mit.1 uc009mit.2 uc009mit.3 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.191607.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## nucleotide binding ATP binding cytoplasm mitochondrion cytosol ATPase activity endoribonuclease inhibitor activity negative regulation of endoribonuclease activity uc009mit.1 uc009mit.2 uc009mit.3 
ENSMUST00000080537.14 Rac1 ENSMUST00000080537.14 Rac family small GTPase 1, transcript variant 2 (from RefSeq NM_009007.2) ENSMUST00000080537.1 ENSMUST00000080537.10 ENSMUST00000080537.11 ENSMUST00000080537.12 ENSMUST00000080537.13 ENSMUST00000080537.2 ENSMUST00000080537.3 ENSMUST00000080537.4 ENSMUST00000080537.5 ENSMUST00000080537.6 ENSMUST00000080537.7 ENSMUST00000080537.8 ENSMUST00000080537.9 NM_009007 O95501 P15154 P63001 Q9BTB4 RAC1_MOUSE Rac1 uc009akk.1 uc009akk.2 uc009akk.3 Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states (PubMed:24352656). In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13- mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1- dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. In neurons, is involved in dendritic spine formation and synaptic plasticity (PubMed:24352656, PubMed:26969129). In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX (PubMed:12695502). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. GTP hydrolysis is stimulated by ARHGAP30 and ARHGAP44. Interacts with the GEF proteins PREX1, FARP1, FARP2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with BAIAP2, BAIAP2L1, PLXNB1, CYFIP1/SRA-1 and DEF6. Interacts with TBC1D2. Interacts with UNKL. Interacts with USP6. Interacts with SPATA13. Interacts with ITGB4. Interacts with the GTP-bound form of RAB7A. Interacts with ARHGEF2. Interacts with ARHGEF16; mediates activation of RAC1 by EPHA2. Interacts with NOXA1. Interacts with S100A8 and calprotectin (S100A8/9). Interacts with ARHGDIA; the interaction is induced by SEMA5A, mediated through PLXNB3 and inactivates and stabilizes RAC1. Interacts with PACSIN2. Interacts with ITGB1BP1 (By similarity). Interacts with the GEF protein RASGRF2, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a complex with MAP2K3, MAP3K3 and CCM2. Interacts with NISCH. Interacts with PIP5K1A. Interacts (GTP-bound form preferentially) with PKN2 (via the REM repeats); the interaction stimulates autophosphorylation and phosphorylation of PKN2. Interacts with SRGAP2. Interacts with PLXNB3. Interacts (when active) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RAPH1 (via Ras associating and PH domains) (By similarity). Interacts with MTSS2 (via IMD domain); this interaction may be important to potentiate PDGF-induced RAC1 activation. Interacts (GTP-bound form) with SH3RF3. Interacts with PAK2 (By similarity). Interacts (GTP-bound form) with SH3RF1 (PubMed:22959435). Found in a complex with SH3RF1, MAPK8IP1/JIP1, MAP3K11/MLK3, MAP2K7/MKK7 and MAPK8/JNK1 (PubMed:23963642). Interacts (both active GTP- or inactive GDP-bound forms) with SH3RF2 (By similarity). Interacts (GTP-bound form preferentially) with CYRIB (By similarity). Interacts with DOCK4 (via DOCKER domain); functions as a guanine nucleotide exchange factor (GEF) for RAC1 (By similarity). Interacts with GARRE1 (By similarity). Interacts with RAP1GDS1 (By similarity). Interacts with TNFAIP8L2 (By similarity). P63001; Q62108: Dlg4; NbExp=3; IntAct=EBI-413646, EBI-300895; P63001; P08228: Sod1; NbExp=4; IntAct=EBI-413646, EBI-1635090; P63001; Q13153: PAK1; Xeno; NbExp=3; IntAct=EBI-413646, EBI-1307; Cell membrane ; Lipid-anchor ; Cytoplasmic side Melanosome Cytoplasm Cell projection, lamellipodium Cell projection, dendrite Synapse Nucleus Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C- terminal cysteine (By similarity). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts (By similarity). Localizes to the lamellipodium in a SH3RF1-dependent manner. In macrophages, cytoplasmic location increases upon CSF1 stimulation (PubMed:17116687). Activation by GTP-binding promotes nuclear localization (By similarity). Widely expressed. Expressed in the neocortical neurons in the developing brain. The effector region mediates interaction with DEF6. GTP-bound active form is ubiquitinated by HACE1, leading to its degradation by the proteasome. Phosphorylated by AKT at Ser-71. Ubiquitinated at Lys-166 in a FBXL19-mediated manner; leading to proteasomal degradation. Conditional knockout of Rac1 in the telencephalic ventricular zone of embryos leads to primary microcephaly. Self- renewal, survival, and differentiation of telencephalic neural progenitor cells is affected. Belongs to the small GTPase superfamily. Rho family. Golgi membrane nucleotide binding pericentriolar material neuron migration phagocytic cup positive regulation of protein phosphorylation auditory receptor cell morphogenesis mast cell chemotaxis epithelial cell morphogenesis GTPase activity protein binding GTP binding nucleus cytoplasm trans-Golgi network cytosol plasma membrane cell cortex endocytosis phagocytosis, engulfment chemotaxis hyperosmotic response cytoskeleton organization actin filament organization cell adhesion establishment or maintenance of cell polarity G-protein coupled receptor signaling pathway small GTPase mediated signal transduction Rho protein signal transduction axon guidance motor neuron axon guidance cell proliferation regulation of cell shape regulation of cell size regulation of lamellipodium assembly positive regulation of lamellipodium assembly regulation of fibroblast migration positive regulation of cell-substrate adhesion regulation of neuron maturation membrane dendrite development cell migration Rac protein signal transduction hydrolase activity Rab GTPase binding extrinsic component of plasma membrane enzyme binding protein kinase binding cerebral cortex radially oriented cell migration embryonic olfactory bulb interneuron precursor migration cerebral cortex GABAergic interneuron development regulation of cell morphogenesis lamellipodium cell projection assembly lamellipodium assembly actin cytoskeleton organization actin filament polymerization regulation of cell migration dendrite GTP-dependent protein binding positive regulation of actin filament polymerization forebrain development positive regulation of microtubule polymerization cytoplasmic vesicle ruffle organization early endosome membrane thioesterase binding ruffle membrane negative regulation of interleukin-23 production regulation of actin cytoskeleton organization substrate adhesion-dependent cell spreading non-canonical Wnt signaling pathway positive regulation of insulin secretion involved in cellular response to glucose stimulus cytoplasmic ribonucleoprotein granule melanosome histone deacetylase binding cell projection dendritic spine positive regulation of phosphatidylinositol 3-kinase activity engulfment of apoptotic cell macromolecular complex binding cell-cell junction organization regulation of nitric oxide biosynthetic process bone resorption positive regulation of DNA replication hepatocyte growth factor receptor signaling pathway regulation of neuronal synaptic plasticity anatomical structure arrangement neuron projection morphogenesis dendrite morphogenesis cell motility homeostasis of number of cells within a tissue Rho GDP-dissociation inhibitor binding ATPase binding regulation of stress fiber assembly positive regulation of stress fiber assembly localization within membrane positive regulation of focal adhesion assembly synaptic transmission, GABAergic recycling endosome membrane Wnt signaling pathway, planar cell polarity pathway kinocilium regulation of respiratory burst positive regulation of dendritic spine development cellular response to mechanical stimulus semaphorin-plexin signaling pathway dopaminergic neuron differentiation protein localization to plasma membrane positive regulation of neutrophil chemotaxis cochlea morphogenesis ruffle assembly postsynapse glutamatergic synapse positive regulation of substrate adhesion-dependent cell spreading regulation of neutrophil migration midbrain dopaminergic neuron differentiation actin filament uc009akk.1 uc009akk.2 uc009akk.3 
ENSMUST00000080553.9 Deaf1 ENSMUST00000080553.9 DEAF1, transcription factor, transcript variant 1 (from RefSeq NM_016874.3) C7SHZ9 DEAF1_MOUSE ENSMUST00000080553.1 ENSMUST00000080553.2 ENSMUST00000080553.3 ENSMUST00000080553.4 ENSMUST00000080553.5 ENSMUST00000080553.6 ENSMUST00000080553.7 ENSMUST00000080553.8 NM_016874 Q3UJA4 Q9Z1T5 uc009kkn.1 uc009kkn.2 uc009kkn.3 uc009kkn.4 Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction (By similarity). Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 2. Isoform 2 may inhibit transcriptional activity of isoform 1 by interacting with it and retaining it in the cytoplasm. Transcriptional activator of EIF4G3 (By similarity). May also involved in behavior (PubMed:24726472). Homodimer (By similarity). Isoform 1 and isoform 2 may form a heterodimer. May interact with the corepressors NCOR1 and NCRO2 (By similarity). Identified in a complex with XRCC5 and XRCC6. Interacts (via the SAND domain) with the DNA-PK complex subunit XRCC6; the interaction is direct with XRCC6 and may be inhibited by DNA-binding (By similarity). Interacts with LMO4; LMO4 blocks export from nucleus. Interacts with LMO2 and CLIM2. Q9Z1T5; Q9Z2D6: Mecp2; NbExp=2; IntAct=EBI-2364863, EBI-1188816; [Isoform 1]: Nucleus. Cytoplasm [Isoform 2]: Cytoplasm. Nucleus. Note=Displays some nuclear localization when expressed with isoform 1, suggesting that it may heterodimerize with isoform 1 and shuttle to the nucleus using the nuclear localization signal of isoform 1. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=DF1; IsoId=Q9Z1T5-1; Sequence=Displayed; Name=2; Synonyms=DF1-VAR1; IsoId=Q9Z1T5-2; Sequence=VSP_038703, VSP_038704, VSP_038705; Ubiquitously expressed during embryogenesis, with higher expression in regions of the central nervous system, dorsal root ganglia, submandibular gland, epidermis and breast. In 12-week-old NOD mice, expression of isoform 2 is sevenfold higher in lymph node stromal elements than in T-cells and tenfold higher than in B-cells. Expressed at all stages of mammary gland development with slightly higher levels observed during pregnancy and lactation. At 4 weeks, expression levels of isoform 1 and isoform 2 do not differ in pancreatic lymph nodes of nonobese diabetic (NOD) mice compared to NOD.B10 mice which do not develop diabetes. However, at 12 weeks, expression of isoform 1 is down-regulated while expression of isoform 2 is up-regulated in NOD mice but not in NOD.B10. There is no difference in expression levels at 12 weeks in spleen. May be phosphorylated by DNA-PK complex in a DNA independent manner (in vitro). Exencephaly and skeletal abnormalities in the rib cage and cervical vertebrae but no presphenoid bone or cranial nerve defects. DEAF1 homozygous mice neonates die 100% of the time and DEAF1 heterozygous mice survived in a 2:1 ratio. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding fibrillar center behavioral fear response neural tube closure DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex cytoplasm regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development nervous system development visual learning regulation of mammary gland epithelial cell proliferation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding embryonic skeletal system development uc009kkn.1 uc009kkn.2 uc009kkn.3 uc009kkn.4 
ENSMUST00000080557.12 Pex5 ENSMUST00000080557.12 peroxisomal biogenesis factor 5, transcript variant 10 (from RefSeq NR_176972.1) ENSMUST00000080557.1 ENSMUST00000080557.10 ENSMUST00000080557.11 ENSMUST00000080557.2 ENSMUST00000080557.3 ENSMUST00000080557.4 ENSMUST00000080557.5 ENSMUST00000080557.6 ENSMUST00000080557.7 ENSMUST00000080557.8 ENSMUST00000080557.9 NR_176972 O09012 PEX5_MOUSE Pex5 Pxr1 Q3UM58 Q8K2V5 Q91YC7 uc009dqt.1 uc009dqt.2 uc009dqt.3 Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle. [Isoform 1]: In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5. [Isoform 2]: Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. Cys-11 acts as a sensor of redox state. In response to oxidative stress, monoubiquitination at Cys-11 is prevented. Interacts (via WxxxF/Y and LVxEF motifs) with PEX14; promoting translocation through the PEX13-PEX14 docking complex. Interacts with PEX12. Interacts (Cys-linked ubiquitinated) with ZFAND6. Interacts (when ubiquitinated at Lys-210) with p62/SQSTM1. [Isoform 1]: Interacts with PEX7, promoting peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. Cytoplasm, cytosol Peroxisome matrix Note=Cycles between the cytosol and the peroxisome matrix (By similarity). Following binding to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, recruited to the docking complex, composed of PEX13 and PEX14, leading to translocation into the peroxisome matrix along with cargo proteins. Export and recycling to the cytosol is initiated by binding to the PEX2-PEX10-PEX12 ligase complex via its unstructured N-terminus that inserts into the ligase pore and emerges in the cytosol (By similarity). Cys-11 of PEX5 is then monoubiquitinated, promoting its extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex (By similarity). Extraction is accompanied by unfolding of the TPR repeats and release of bound cargo in the peroxisome matrix. The TPR repeats refold in the cytosol and ubiquitination is removed by deubiquitinating enzymes, resetting PEX5 for a subsequent import cycle (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long, PEX5L ; IsoId=O09012-1; Sequence=Displayed; Name=2; Synonyms=PEX5S ; IsoId=O09012-2; Sequence=VSP_024107; The TPR repeats mediate interaction with proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL- type). The WxxxF/Y motifs mediate interaction with PEX14, promoting association with the PEX13-PEX14 docking complex. The amphipathic helix 1 and 2 (AH1 and AH2, respectively) are required for PEX5 retrotranslocation and recycling. AH2 mediates interaction with lumenal side of the PEX2-PEX10-PEX12 ligase complex, while AH1 is required for extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex. Monoubiquitinated at Cys-11 by PEX2 during PEX5 passage through the retrotranslocation channel (By similarity). Cys-11 monoubiquitination acts as a recognition signal for the PEX1-PEX6 complex and is required for PEX5 extraction and export from peroxisomes. Monoubiquitination at Cys-11 is removed by USP9X in the cytosol, resetting PEX5 for a subsequent import cycle (By similarity). When PEX5 recycling is compromised, polyubiquitinated by PEX10 during its passage through the retrotranslocation channel, leading to its degradation (By similarity). Monoubiquitination at Lys-472 by TRIM37 promotes its stability by preventing its polyubiquitination and degradation by the proteasome. Ubiquitination at Lys-527 is not mediated by the PEX2-PEX10-PEX12 ligase complex and is not related to PEX5 recycling. Monoubiquitinated at Lys-210 by PEX2 following phosphorylation by ATM in response to starvation or reactive oxygen species (ROS), leading to PEX5 recognition by p62/SQSTM1 and induction of pexophagy (By similarity). Phosphorylated at Ser-141 by ATM in response to reactive oxygen species (ROS), promoting monoubiquitination at Lys-210 and induction of pexophagy. Liver-specific knockout mice display a growth retardation from the third postnatal week resulting in a 30% to 40% lower body weight than control mice at the age of 7 weeks (PubMed:15732085). Thereafter, mice tend to catch up in growth, and by 3 months their weight is not different from control mice (PubMed:15732085). Throughout this period, the mice look healthy, are fertile and liver function is unaffected (PubMed:15732085). However, 10-week-old mutant mice display a severe hepatomegaly due to hypertrophic and hyperplastic hepatocytes (PubMed:15732085). Mutant mice survive but develope extensive liver tumors from 12 months on (PubMed:15732085). Peroxisomes are absent in mutant hepatocytes and multiple ultrastructural alterations are noticed, smooth endoplasmic reticulum proliferation, and accumulation of lipid droplets and lysosomes (PubMed:15732085). Most prominent is the abnormal structure of the inner mitochondrial membrane (PubMed:15732085). This is accompanied by severely reduced activities of complex I, III, and V and a collapse of the mitochondrial inner membrane potential (PubMed:15732085). Liver-specific knockout mice display severely impaired oxidation of 2-methylhexadecanoic acid, the bile acid intermediate trihydroxycholestanoic acid (THCA), and tetradecanedioic acid (PubMed:17442273). In contrast, mitochondrial beta-oxidation rates of palmitate are doubled (PubMed:17442273). Lens-specific knockout mice develop cataracts (PubMed:33389129). Belongs to the peroxisomal targeting signal receptor family. very long-chain fatty acid metabolic process peroxisome targeting sequence binding neuron migration peroxisome matrix targeting signal-1 binding cell cytoplasm mitochondrion peroxisome peroxisomal membrane peroxisomal matrix Golgi apparatus cytosol protein targeting to peroxisome fatty acid beta-oxidation mitochondrion organization mitochondrial membrane organization endoplasmic reticulum organization peroxisome organization protein C-terminus binding protein transport membrane protein import into peroxisome matrix protein import into peroxisome matrix, docking protein import into peroxisome matrix, translocation enzyme binding cerebral cortex cell migration cerebral cortex neuron differentiation small GTPase binding macromolecular complex positive regulation of multicellular organism growth cellular lipid metabolic process protein import into peroxisome membrane protein N-terminus binding cell development neuromuscular process protein tetramerization negative regulation of protein homotetramerization uc009dqt.1 uc009dqt.2 uc009dqt.3 
ENSMUST00000080560.9 Sema3f ENSMUST00000080560.9 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F, transcript variant 2 (from RefSeq NM_011349.4) E9QNC5 ENSMUST00000080560.1 ENSMUST00000080560.2 ENSMUST00000080560.3 ENSMUST00000080560.4 ENSMUST00000080560.5 ENSMUST00000080560.6 ENSMUST00000080560.7 ENSMUST00000080560.8 NM_011349 O88632 O88633 SEM3F_MOUSE uc009rmu.1 uc009rmu.2 uc009rmu.3 Secreted Event=Alternative splicing; Named isoforms=2; Name=B; IsoId=O88632-1; Sequence=Displayed; Name=A; IsoId=O88632-2; Sequence=VSP_006042; Expressed ubiquitously in adulthood. During embryogenesis, expressed in subregions of the central nervous system and various other tissues like skin, kidney, lung and intestine. Belongs to the semaphorin family. neural crest cell migration extracellular region extracellular space integral component of plasma membrane axon guidance facial nerve structural organization trigeminal nerve structural organization nerve development branchiomotor neuron axon guidance semaphorin receptor binding positive regulation of cell migration ventral trunk neural crest cell migration locomotion chemorepellent activity negative regulation of axon extension involved in axon guidance axon extension involved in axon guidance negative chemotaxis sympathetic ganglion development semaphorin-plexin signaling pathway sympathetic neuron projection extension sympathetic neuron projection guidance glutamatergic synapse neural crest cell migration involved in autonomic nervous system development semaphorin-plexin signaling pathway involved in neuron projection guidance semaphorin-plexin signaling pathway involved in axon guidance uc009rmu.1 uc009rmu.2 uc009rmu.3 
ENSMUST00000080595.3 Prl7b1 ENSMUST00000080595.3 prolactin family 7, subfamily b, member 1 (from RefSeq NM_029355.2) ENSMUST00000080595.1 ENSMUST00000080595.2 NM_029355 PR7B1_MOUSE Prlpn Q14AN3 Q8CGZ9 Q9DAX1 uc007pxx.1 uc007pxx.2 Secreted Expression restricted to placenta. Abundantly expressed in trophoblast cells of the junctional zone and trophoblasts migrating into the mesometrial decidua. Detectable throughout the second half of gestation. Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pxx.1 uc007pxx.2 
ENSMUST00000080606.9 Mup19 ENSMUST00000080606.9 major urinary protein 19 (from RefSeq NM_001135127.2) ENSMUST00000080606.1 ENSMUST00000080606.2 ENSMUST00000080606.3 ENSMUST00000080606.4 ENSMUST00000080606.5 ENSMUST00000080606.6 ENSMUST00000080606.7 ENSMUST00000080606.8 MUP6_MOUSE Mup6 NM_001135127 P02762 P70119 Q78EF5 Q91V46 uc008tbo.1 uc008tbo.2 uc008tbo.3 uc008tbo.4 uc008tbo.5 uc008tbo.6 Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females. Secreted. Abundant in the urine of adult male mice but absent from that of females. Causes an allergic reaction in human. There are about 15 group 1 MUP genes and their transcripts make up about 5% of male mouse liver RNA. Belongs to the calycin superfamily. Lipocalin family. insulin-activated receptor activity pheromone binding extracellular region extracellular space nucleus cytosol energy reserve metabolic process insulin receptor signaling pathway aerobic respiration positive regulation of gene expression negative regulation of lipid storage positive regulation of glucose metabolic process heat generation small molecule binding glucose homeostasis locomotor rhythm negative regulation of gluconeogenesis positive regulation of lipid metabolic process negative regulation of transcription, DNA-templated negative regulation of lipid biosynthetic process positive regulation of protein kinase B signaling negative regulation of insulin secretion involved in cellular response to glucose stimulus mitochondrion morphogenesis cellular response to lipid uc008tbo.1 uc008tbo.2 uc008tbo.3 uc008tbo.4 uc008tbo.5 uc008tbo.6 
ENSMUST00000080619.3 Tas2r114 ENSMUST00000080619.3 taste receptor, type 2, member 114 (from RefSeq NM_207019.1) ENSMUST00000080619.1 ENSMUST00000080619.2 NM_207019 Q7M722 T2r46 TR114_MOUSE Tas2r114 uc009eja.1 uc009eja.2 Putative taste receptor which may play a role in the perception of bitterness. Membrane ; Multi-pass membrane protein Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009eja.1 uc009eja.2 
ENSMUST00000080622.9 Snu13 ENSMUST00000080622.9 SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) (from RefSeq NM_011482.4) ENSMUST00000080622.1 ENSMUST00000080622.2 ENSMUST00000080622.3 ENSMUST00000080622.4 ENSMUST00000080622.5 ENSMUST00000080622.6 ENSMUST00000080622.7 ENSMUST00000080622.8 NH2L1_MOUSE NM_011482 Nhp2l1 O08754 Q3UY64 Q9D0T1 Snu13 Ssfa1 uc007wya.1 uc007wya.2 uc007wya.3 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. Identified in the spliceosome B complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Interacts with RAD17 and PRPF31. The complex formed by SNU13 and PRPF31 binds U4 snRNA. The complex formed by SNU13 and PRPF31 binds also U4atac snRNA, a characteristic component of specific, less abundant spliceosomal complexes. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus Nucleus, nucleolus Note=Concentrated in the dense fibrillar component of the nucleolus. Belongs to the eukaryotic ribosomal protein eL8 family. Sequence=AAC53177.1; Type=Frameshift; Evidence=; mRNA splicing, via spliceosome maturation of LSU-rRNA box C/D snoRNP assembly dense fibrillar component RNA binding nucleus spliceosomal complex U4atac snRNP nucleolus plasma membrane mRNA processing single fertilization RNA splicing snoRNA binding U4 snRNA binding U4atac snRNA binding box C/D snoRNP complex small-subunit processome macromolecular complex U3 snoRNA binding box C/D snoRNA binding ribosome biogenesis U4/U6 x U5 tri-snRNP complex ATPase binding U2-type precatalytic spliceosome ribonucleoprotein complex uc007wya.1 uc007wya.2 uc007wya.3 
ENSMUST00000080626.9 Fbxw22 ENSMUST00000080626.9 F-box and WD-40 domain protein 22, transcript variant 1 (from RefSeq NM_001014395.2) EG382156 ENSMUST00000080626.1 ENSMUST00000080626.2 ENSMUST00000080626.3 ENSMUST00000080626.4 ENSMUST00000080626.5 ENSMUST00000080626.6 ENSMUST00000080626.7 ENSMUST00000080626.8 Fbxw22 NM_001014395 Q5XG67 Q5XG67_MOUSE uc009rsi.1 uc009rsi.2 uc009rsi.3 uc009rsi.4 uc009rsi.5 molecular_function cellular_component biological_process uc009rsi.1 uc009rsi.2 uc009rsi.3 uc009rsi.4 uc009rsi.5 
ENSMUST00000080635.4 Scgb1b2 ENSMUST00000080635.4 secretoglobin, family 1B, member 2 (from RefSeq NM_020563.3) Abpa2 Abph Apbh ENSMUST00000080635.1 ENSMUST00000080635.2 ENSMUST00000080635.3 Mja1l NM_020563 O35176 O35176_MOUSE Scgb1b2 uc009gii.1 uc009gii.2 uc009gii.3 uc009gii.4 Secreted steroid binding extracellular region biological_process uc009gii.1 uc009gii.2 uc009gii.3 uc009gii.4 
ENSMUST00000080647.5 Smok2a ENSMUST00000080647.5 sperm motility kinase 2A (from RefSeq NM_013741.2) ENSMUST00000080647.1 ENSMUST00000080647.2 ENSMUST00000080647.3 ENSMUST00000080647.4 G5E8M0 G5E8M0_MOUSE NM_013741 Smok2a uc012akl.1 uc012akl.2 May play a role in sperm motility, especially in the regulation of flagellar function. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily. protein kinase activity ATP binding protein phosphorylation uc012akl.1 uc012akl.2 
ENSMUST00000080654.7 Cdhr5 ENSMUST00000080654.7 cadherin-related family member 5, transcript variant 2 (from RefSeq NM_028069.3) CDHR5_MOUSE Cdhr5 ENSMUST00000080654.1 ENSMUST00000080654.2 ENSMUST00000080654.3 ENSMUST00000080654.4 ENSMUST00000080654.5 ENSMUST00000080654.6 Mucdhl Mupcdh NM_028069 Q8CEJ3 Q8VHF2 Q9D8I9 uc009kkj.1 uc009kkj.2 uc009kkj.3 uc009kkj.4 Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5. Interacts (via cytoplasmic domain) with USH1C and MYO7B; required for proper localization of CDHR5 to microvilli tips and its function in brush border differentiation. Apical cell membrane ; Single-pass type I membrane protein Cell projection, microvillus membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8VHF2-1; Sequence=Displayed; Name=2 ; IsoId=Q8VHF2-2; Sequence=VSP_050689; Detected at embryonic day 7. Expression decreases by day 11 and increases again between embryonic days 15 and 17. N- and O-glycosylated. calcium ion binding plasma membrane integral component of plasma membrane clathrin-coated pit cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules beta-catenin binding membrane integral component of membrane apical plasma membrane cell differentiation brush border membrane microvillus membrane regulation of microvillus length cell projection spanning component of plasma membrane cell adhesion molecule binding intermicrovillar adhesion uc009kkj.1 uc009kkj.2 uc009kkj.3 uc009kkj.4 
ENSMUST00000080665.10 Dnah9 ENSMUST00000080665.10 dynein, axonemal, heavy chain 9 (from RefSeq NM_001099633.2) B1AR51 B1AR51_MOUSE Dnah9 Dnahc9 ENSMUST00000080665.1 ENSMUST00000080665.2 ENSMUST00000080665.3 ENSMUST00000080665.4 ENSMUST00000080665.5 ENSMUST00000080665.6 ENSMUST00000080665.7 ENSMUST00000080665.8 ENSMUST00000080665.9 NM_001099633 RP23-215H18.2-001 uc007jlg.1 uc007jlg.2 uc007jlg.3 Belongs to the dynein heavy chain family. cilium movement microtubule motor activity ATP binding axoneme microtubule-based movement ATP-dependent microtubule motor activity, minus-end-directed dynein complex motile cilium dynein intermediate chain binding dynein light intermediate chain binding 9+2 motile cilium uc007jlg.1 uc007jlg.2 uc007jlg.3 
ENSMUST00000080669.6 Krtap5-20 ENSMUST00000080669.6 predicted gene 4559 (from RefSeq NM_001199309.1) A4IF42 A4IF42_MOUSE ENSMUST00000080669.1 ENSMUST00000080669.2 ENSMUST00000080669.3 ENSMUST00000080669.4 ENSMUST00000080669.5 Gm4559 NM_001199309 uc033jdh.1 uc033jdh.2 molecular_function cellular_component biological_process keratin filament uc033jdh.1 uc033jdh.2 
ENSMUST00000080698.3 Or5m11 ENSMUST00000080698.3 olfactory receptor family 5 subfamily M member 11 (from RefSeq NM_001011774.2) ENSMUST00000080698.1 ENSMUST00000080698.2 NM_001011774 Olfr1028 Olfr1534-ps1 Or5m11 Q7TR89 Q7TR89_MOUSE uc008klf.1 uc008klf.2 uc008klf.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008klf.1 uc008klf.2 uc008klf.3 
ENSMUST00000080713.5 Utp14a ENSMUST00000080713.5 UTP14A small subunit processome component (from RefSeq NM_028276.1) A2AFX7 ENSMUST00000080713.1 ENSMUST00000080713.2 ENSMUST00000080713.3 ENSMUST00000080713.4 JsdX Kiaa0266 NM_028276 Q640M1 Q6A094 Q6EJB4 Q6P6L1 Q9CZK8 UT14A_MOUSE uc009tcb.1 uc009tcb.2 uc009tcb.3 May be required for ribosome biogenesis. Interacts with DHX37. Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q640M1-1; Sequence=Displayed; Name=2; IsoId=Q640M1-2; Sequence=VSP_014477, VSP_014478; Ubiquitously expressed. Citrullinated by PADI4. The mouse genome also contains the Utp14b gene, an autosomal retrotransposed copy of this X-linked gene. Evolution of autosomal retrogenes from X-linked progenitors compensates for X- chromosome silencing during male meiosis. Belongs to the UTP14 family. Sequence=AAH62165.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAQ87011.1; Type=Frameshift; Evidence=; Sequence=BAD32202.1; Type=Erroneous initiation; Evidence=; nucleus nucleolus cytosol rRNA processing small-subunit processome ribosome biogenesis uc009tcb.1 uc009tcb.2 uc009tcb.3 
ENSMUST00000080718.6 Lypd3 ENSMUST00000080718.6 Ly6/Plaur domain containing 3 (from RefSeq NM_133743.1) C4.4a ENSMUST00000080718.1 ENSMUST00000080718.2 ENSMUST00000080718.3 ENSMUST00000080718.4 ENSMUST00000080718.5 LYPD3_MOUSE NM_133743 Q91YK8 uc009fqe.1 uc009fqe.2 uc009fqe.3 Supports cell migration. May be involved in tumor progression (By similarity). Binds laminin-1 and laminin-5. Interacts with LGALS3. Interacts with AGR2 and AGR3 (By similarity). Cell membrane ; Lipid-anchor, GPI- anchor Up-regulated in suprabasal keratinocytes of hyperplastic skin induced by phorbol-ester. plasma membrane cell-matrix adhesion membrane integral component of membrane anchored component of membrane laminin binding uc009fqe.1 uc009fqe.2 uc009fqe.3 
ENSMUST00000080721.6 Chsy3 ENSMUST00000080721.6 chondroitin sulfate synthase 3 (from RefSeq NM_001081328.1) B2RXU7 CHSS3_MOUSE Chsy2 Css3 ENSMUST00000080721.1 ENSMUST00000080721.2 ENSMUST00000080721.3 ENSMUST00000080721.4 ENSMUST00000080721.5 Kiaa4168 NM_001081328 Q5DTK1 uc008ezw.1 uc008ezw.2 uc008ezw.3 uc008ezw.4 Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. Reaction=3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA- (1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl- [protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc- (1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)- beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:20800, Rhea:RHEA-COMP:14058, Rhea:RHEA- COMP:14059, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:138442, ChEBI:CHEBI:138443; EC=2.4.1.175; Reaction=3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA- (1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)- beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha- D-galactosamine = 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA- (1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal- (1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:55000, Rhea:RHEA-COMP:14060, Rhea:RHEA-COMP:14301, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:138444, ChEBI:CHEBI:138445; EC=2.4.1.175; Reaction=3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal- (1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D- glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl- [protein] + H(+) + UDP; Xref=Rhea:RHEA:23428, Rhea:RHEA-COMP:12575, Rhea:RHEA-COMP:14058, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132105, ChEBI:CHEBI:138442; EC=2.4.1.226; Reaction=3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D- GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)- beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta- D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D- GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)- beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:54996, Rhea:RHEA-COMP:14060, Rhea:RHEA-COMP:14061, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:138444, ChEBI:CHEBI:138445; EC=2.4.1.226; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Cd(2+); Xref=ChEBI:CHEBI:48775; Evidence=; Note=Divalent metal cations. Highest activities are measured with Co(2+), Mn(2+) and Cd(2+). ; Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Belongs to the chondroitin N- acetylgalactosaminyltransferase family. Sequence=BAD90307.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component Golgi apparatus biological_process acetylgalactosaminyltransferase activity membrane integral component of membrane transferase activity Golgi cisterna membrane metal ion binding glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity uc008ezw.1 uc008ezw.2 uc008ezw.3 uc008ezw.4 
ENSMUST00000080723.11 Tax1bp1 ENSMUST00000080723.11 Tax1 (human T cell leukemia virus type I) binding protein 1, transcript variant 1 (from RefSeq NM_025816.3) ENSMUST00000080723.1 ENSMUST00000080723.10 ENSMUST00000080723.2 ENSMUST00000080723.3 ENSMUST00000080723.4 ENSMUST00000080723.5 ENSMUST00000080723.6 ENSMUST00000080723.7 ENSMUST00000080723.8 ENSMUST00000080723.9 NM_025816 Q3UKC1 Q91YT6 Q9CVF0 Q9DC45 TAXB1_MOUSE uc009byz.1 uc009byz.2 uc009byz.3 uc009byz.4 Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:18239685, PubMed:33207181). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates. Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (By similarity). Recruits also A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:18239685). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (By similarity). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis. Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (By similarity). Homooligomer. Interacts with TNFAIP3. Interacts with STARD13. Interacts with MYO6. Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and TAX1BP1. Interacts with MAVS; this interaction induces MAVS polyubiquitination. Interacts with TNIP1. Interacts with TRAF6; this interaction mediates deubiquitination of TRAF6 and inhibition of NF- kappa-B activation. Interacts with RIPK1; this interaction negatively regulates RIPK1 ubiquitination (PubMed:18239685). Interacts with NBR1. Interacts with TBK1. Interacts with RB1CC1. Interacts with SQSTM1. Interacts with AZI2. Cytoplasm Mitochondrion Preautophagosomal structure Cytoplasmic vesicle, autophagosome Expressed at 11.5 dpc and 12.5 dpc in distal limb and genital bud. The C-terminal UBZ-type zinc fingers function as ubiquitin- binding domains. Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation. Mice genetically knocked out for TAX1BP1 show no obvious abnormalities at birth, but develop age-dependent inflammatory cardiac valvulitis, die prematurely, and are hypersensitive to low doses of TNF-alpha and IL-1beta (PubMed:18239685). In addition, TAX1BP1 deletion impairs clearance of ubiquitinated protein aggregates (PubMed:33207181). protein binding apoptotic process kinase binding negative regulation of NF-kappaB transcription factor activity negative regulation of apoptotic process ubiquitin binding metal ion binding uc009byz.1 uc009byz.2 uc009byz.3 uc009byz.4 
ENSMUST00000080742.3 Sval3 ENSMUST00000080742.3 seminal vesicle antigen-like 3 (from RefSeq NM_001003952.1) ENSMUST00000080742.1 ENSMUST00000080742.2 NM_001003952 Q76I99 Q76I99_MOUSE SVAL3 Sval3 uc009bqk.1 uc009bqk.2 Monomer. Interacts with AZGP1. Belongs to the PIP family. regulation of immune system process aspartic-type endopeptidase activity extracellular region extracellular space proteolysis uc009bqk.1 uc009bqk.2 
ENSMUST00000080744.13 Agbl4 ENSMUST00000080744.13 ATP/GTP binding protein-like 4, transcript variant 3 (from RefSeq NM_001284190.2) A2A979 A6PWC5 A6PWC6 Agbl4 CBPC6_MOUSE Ccp6 ENSMUST00000080744.1 ENSMUST00000080744.10 ENSMUST00000080744.11 ENSMUST00000080744.12 ENSMUST00000080744.2 ENSMUST00000080744.3 ENSMUST00000080744.4 ENSMUST00000080744.5 ENSMUST00000080744.6 ENSMUST00000080744.7 ENSMUST00000080744.8 ENSMUST00000080744.9 NM_001284190 Q09LZ8 Q09LZ9 uc008udd.1 uc008udd.2 uc008udd.3 uc008udd.4 Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:21074048, PubMed:25103237, PubMed:26829768, PubMed:29593216). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein (PubMed:21074048, PubMed:25103237). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:25103237). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK (PubMed:21074048). Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (PubMed:26829768). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). Reaction=(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L- glutamate; Xref=Rhea:RHEA:60004, Rhea:RHEA-COMP:15519, Rhea:RHEA- COMP:15675, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:143623; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60005; Evidence= Reaction=C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L- glutamate; Xref=Rhea:RHEA:63792, Rhea:RHEA-COMP:16435, Rhea:RHEA- COMP:16436, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:149555, ChEBI:CHEBI:149556; EC=3.4.17.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63793; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Interacts with MYLK. Cytoplasm, cytosol Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Golgi apparatus Cytoplasm, cytoskeleton, cilium basal body Note=Colocalizes with gamma- tubulin in the centrioles at interphase and dividing cells and with glutamylated tubulin in basal bodies of ciliated cells. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=2; IsoId=Q09LZ8-1; Sequence=Displayed; Name=2; Synonyms=1; IsoId=Q09LZ8-2; Sequence=VSP_024671, VSP_024672; Widely expressed. Expressed abundantly in testis, pituitary and brain and to a lower extent in eye, stomach, adrenal and kidney. In brain, expressed at low level in cerebellum as compared to cortex. Mice are more vulnerable to DNA virus infection due to impaired immune response. Knockout mice promote somatic cell reprogramming and higher litter size at birth (PubMed:29593216). Knockout blastocytes show enhanced development (PubMed:29593216). Belongs to the peptidase M14 family. Sequence=CAM13964.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM16884.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM16953.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM17710.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM17858.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM19669.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM21591.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM21666.1; Type=Erroneous gene model prediction; Evidence=; carboxypeptidase activity metallocarboxypeptidase activity protein binding cytoplasm Golgi apparatus centriole cytosol cytoskeleton proteolysis peptidase activity metallopeptidase activity zinc ion binding tubulin binding hydrolase activity protein deglutamylation C-terminal protein deglutamylation protein side chain deglutamylation ciliary basal body cell projection metal ion binding defense response to virus uc008udd.1 uc008udd.2 uc008udd.3 uc008udd.4 
ENSMUST00000080755.12 Prl3d2 ENSMUST00000080755.12 prolactin family 3, subfamily d, member 1, transcript variant 2 (from RefSeq NM_172155.2) ENSMUST00000080755.1 ENSMUST00000080755.10 ENSMUST00000080755.11 ENSMUST00000080755.2 ENSMUST00000080755.3 ENSMUST00000080755.4 ENSMUST00000080755.5 ENSMUST00000080755.6 ENSMUST00000080755.7 ENSMUST00000080755.8 ENSMUST00000080755.9 NM_172155 Plib Prl3d2 Q5SZY7 Q8CGZ8 Q8CGZ8_MOUSE uc007pxf.1 uc007pxf.2 uc007pxf.3 Secreted Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pxf.1 uc007pxf.2 uc007pxf.3 
ENSMUST00000080759.5 Or1o3 ENSMUST00000080759.5 olfactory receptor family 1 subfamily O member 3 (from RefSeq NM_146510.1) ENSMUST00000080759.1 ENSMUST00000080759.2 ENSMUST00000080759.3 ENSMUST00000080759.4 NM_146510 Olfr98 Or1o3 Q8VFD9 Q8VFD9_MOUSE uc008cmn.1 uc008cmn.2 uc008cmn.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008cmn.1 uc008cmn.2 uc008cmn.3 
ENSMUST00000080766.8 Tpbpb ENSMUST00000080766.8 trophoblast specific protein beta (from RefSeq NM_026429.4) ENSMUST00000080766.1 ENSMUST00000080766.2 ENSMUST00000080766.3 ENSMUST00000080766.4 ENSMUST00000080766.5 ENSMUST00000080766.6 ENSMUST00000080766.7 NM_026429 Q9CQC0 Q9CQC0_MOUSE Tpbpb uc007qvw.1 uc007qvw.2 uc007qvw.3 uc007qvw.4 molecular_function cellular_component biological_process uc007qvw.1 uc007qvw.2 uc007qvw.3 uc007qvw.4 
ENSMUST00000080771.10 Zbtb24 ENSMUST00000080771.10 zinc finger and BTB domain containing 24, transcript variant 4 (from RefSeq NR_102360.1) Bif1 Bsg1 ENSMUST00000080771.1 ENSMUST00000080771.2 ENSMUST00000080771.3 ENSMUST00000080771.4 ENSMUST00000080771.5 ENSMUST00000080771.6 ENSMUST00000080771.7 ENSMUST00000080771.8 ENSMUST00000080771.9 NR_102360 Q3UIB7 Q7TPC4 Q80X44 Q8CJC9 ZBT24_MOUSE Znf450 uc007exm.1 uc007exm.2 uc007exm.3 uc007exm.4 This gene encodes a protein containing eight C2H2-type zinc fingers and a BTB domain. Expression of this gene is induced by bone morphogenetic protein-2 signaling. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies syndrome-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. May be involved in BMP2-induced transcription. Interacts with MN1. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80X44-1; Sequence=Displayed; Name=2; IsoId=Q80X44-2; Sequence=VSP_016225; Name=3; IsoId=Q80X44-3; Sequence=VSP_016223, VSP_016224; Widely expressed. Highest level in liver, testis and kidney. By BMP2 in fibroblast, myoblast and preosteoblast cell lines. Belongs to the krueppel C2H2-type zinc-finger protein family. hematopoietic progenitor cell differentiation nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc007exm.1 uc007exm.2 uc007exm.3 uc007exm.4 
ENSMUST00000080797.8 Cdh3 ENSMUST00000080797.8 cadherin 3, transcript variant 2 (from RefSeq NM_007665.3) CADH3_MOUSE Cdhp ENSMUST00000080797.1 ENSMUST00000080797.2 ENSMUST00000080797.3 ENSMUST00000080797.4 ENSMUST00000080797.5 ENSMUST00000080797.6 ENSMUST00000080797.7 NM_007665 P10287 Q61465 Q8BSL6 uc009ngh.1 uc009ngh.2 uc009ngh.3 uc009ngh.4 This gene encodes a calcium-dependent cell-cell adhesion protein containing five cadherin domains. The encoded protein plays a role in epithelial outgrowth, such as that which occurs during the development of hair follicles and limb buds. Loss of function of the related gene in humans results in ectodermal dysplasia, ectrodactyly, and macular dystrophy and congential hypotrichosis with juvenile macular dystrophy. This gene is located in the vicinity of similar cadherin genes on chromosome 8. The proprotein is further cleaved into a functional chain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1 and CTNNB1. Cell membrane; Single-pass type I membrane protein. Expression is high in both fetal and newborn testis but minimal in testis of 7-day-old animals. Not detected in testis of 21-day-old or adult. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. cell morphogenesis retina homeostasis calcium ion binding cytoplasm plasma membrane cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cytoskeletal protein binding cell surface positive regulation of gene expression positive regulation of keratinocyte proliferation membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex hair cycle process keratinization positive regulation of monophenol monooxygenase activity negative regulation of transforming growth factor beta2 production adherens junction organization wound healing response to drug protein homodimerization activity positive regulation of insulin-like growth factor receptor signaling pathway cell-cell adhesion mediated by cadherin cadherin binding metal ion binding positive regulation of melanin biosynthetic process negative regulation of catagen regulation of hair cycle by canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway cell-cell adhesion positive regulation of melanosome transport uc009ngh.1 uc009ngh.2 uc009ngh.3 uc009ngh.4 
ENSMUST00000080801.2 Or5b119 ENSMUST00000080801.2 olfactory receptor family 5 subfamily B member 119 (from RefSeq NM_146301.1) ENSMUST00000080801.1 NM_146301 Olfr1475 Or5b119 Q8VEV6 Q8VEV6_MOUSE uc008gvp.1 uc008gvp.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gvp.1 uc008gvp.2 
ENSMUST00000080812.14 Zc3hc1 ENSMUST00000080812.14 zinc finger, C3HC type 1, transcript variant 1 (from RefSeq NM_001311086.1) ENSMUST00000080812.1 ENSMUST00000080812.10 ENSMUST00000080812.11 ENSMUST00000080812.12 ENSMUST00000080812.13 ENSMUST00000080812.2 ENSMUST00000080812.3 ENSMUST00000080812.4 ENSMUST00000080812.5 ENSMUST00000080812.6 ENSMUST00000080812.7 ENSMUST00000080812.8 ENSMUST00000080812.9 NM_001311086 Nipa Q3TJE6 Q80YV2 Q80Z11 Q8BTW5 Q8CI56 Q8R3U7 ZC3C1_MOUSE uc009bfc.1 uc009bfc.2 uc009bfc.3 uc009bfc.4 Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity). Overexpression may be able to protect from apoptosis induced by IL-3 withdrawal. Protein modification; protein ubiquitination. Interacts with SKP1. Component of a SCF(NIPA) E3 complex with SKP1, RBX1 and CUL1 when not phosphorylated on Ser-353. Interacts with CCNB1 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80YV2-1; Sequence=Displayed; Name=2; IsoId=Q80YV2-2; Sequence=VSP_015219; The F-box-like region is required for the interaction with SKP1. Phosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-353 phosphorylation, a major site during the course of cell-cycle-dependent phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation leading to mitotic entry (By similarity). Sequence=AAH37445.1; Type=Erroneous initiation; Evidence=; protein binding nucleus cell cycle zinc ion binding protein ubiquitination protein kinase binding nuclear membrane metal ion binding cell division negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc009bfc.1 uc009bfc.2 uc009bfc.3 uc009bfc.4 
ENSMUST00000080813.5 Rps17 ENSMUST00000080813.5 ribosomal protein S17 (from RefSeq NM_009092.3) ENSMUST00000080813.1 ENSMUST00000080813.2 ENSMUST00000080813.3 ENSMUST00000080813.4 NM_009092 Q5M9L7 Q5M9L7_MOUSE Rps17 uc009ibv.1 uc009ibv.2 uc009ibv.3 Belongs to the eukaryotic ribosomal protein eS17 family. structural constituent of ribosome ribosome rRNA processing translation cytosolic small ribosomal subunit erythrocyte homeostasis ribosomal small subunit biogenesis uc009ibv.1 uc009ibv.2 uc009ibv.3 
ENSMUST00000080817.6 Rnf169 ENSMUST00000080817.6 ring finger protein 169 (from RefSeq NM_175388.3) E9Q7F2 ENSMUST00000080817.1 ENSMUST00000080817.2 ENSMUST00000080817.3 ENSMUST00000080817.4 ENSMUST00000080817.5 Kiaa1991 NM_175388 Q69Z47 RN169_MOUSE uc009img.1 uc009img.2 uc009img.3 uc009img.4 uc009img.5 Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization. Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with DYRK1B. Chromosome Nucleus, nucleoplasm Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products. The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif also mediates interaction with ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs). Phosphorylated by DYRK1A; phosphorylation increases RNF169 ability to block accumulation of TP53BP1 at the DSB sites. Belongs to the RNF169 family. nucleus nucleoplasm cellular response to DNA damage stimulus protein ubiquitination nuclear speck transferase activity nucleosome binding site of double-strand break metal ion binding K63-linked polyubiquitin binding negative regulation of double-strand break repair uc009img.1 uc009img.2 uc009img.3 uc009img.4 uc009img.5 
ENSMUST00000080834.15 Zfp82 ENSMUST00000080834.15 zinc finger protein 82, transcript variant 1 (from RefSeq NM_177889.5) ENSMUST00000080834.1 ENSMUST00000080834.10 ENSMUST00000080834.11 ENSMUST00000080834.12 ENSMUST00000080834.13 ENSMUST00000080834.14 ENSMUST00000080834.2 ENSMUST00000080834.3 ENSMUST00000080834.4 ENSMUST00000080834.5 ENSMUST00000080834.6 ENSMUST00000080834.7 ENSMUST00000080834.8 ENSMUST00000080834.9 Kiaa1948 NM_177889 Q6P9Y7 Q6ZPG0 Q8BIP1 ZFP82_MOUSE Znf545 uc009gda.1 uc009gda.2 uc009gda.3 uc009gda.4 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P9Y7-1; Sequence=Displayed; Name=2; IsoId=Q6P9Y7-2; Sequence=VSP_018083; Name=3; IsoId=Q6P9Y7-3; Sequence=VSP_046230, VSP_046231; Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC29755.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009gda.1 uc009gda.2 uc009gda.3 uc009gda.4 
ENSMUST00000080839.2 Xlr3c ENSMUST00000080839.2 X-linked lymphocyte-regulated 3C (from RefSeq NM_011727.2) B1B0S0 B1B0S0_MOUSE ENSMUST00000080839.1 NM_011727 Xlr3c uc009tln.1 uc009tln.2 Belongs to the XLR/SYCP3 family. uc009tln.1 uc009tln.2 
ENSMUST00000080849.6 Prb1c ENSMUST00000080849.6 proline-rich protein BstNI subfamily 1C (from RefSeq NM_001177588.1) E9Q7E4 E9Q7E4_MOUSE ENSMUST00000080849.1 ENSMUST00000080849.2 ENSMUST00000080849.3 ENSMUST00000080849.4 ENSMUST00000080849.5 Gm8882 NM_001177588 Prb1c uc291joh.1 uc291joh.2 molecular_function cellular_component biological_process uc291joh.1 uc291joh.2 
ENSMUST00000080856.14 Ipo11 ENSMUST00000080856.14 importin 11, transcript variant 1 (from RefSeq NM_029665.4) ENSMUST00000080856.1 ENSMUST00000080856.10 ENSMUST00000080856.11 ENSMUST00000080856.12 ENSMUST00000080856.13 ENSMUST00000080856.2 ENSMUST00000080856.3 ENSMUST00000080856.4 ENSMUST00000080856.5 ENSMUST00000080856.6 ENSMUST00000080856.7 ENSMUST00000080856.8 ENSMUST00000080856.9 IPO11_MOUSE NM_029665 Q8BU45 Q8K0B4 Q8K2V6 Ranbp11 uc007rtx.1 uc007rtx.2 uc007rtx.3 Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPL12, and of UBE2E3 (By similarity). Interacts with UBE2E3 and RPL12. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2V6-1; Sequence=Displayed; Name=2; IsoId=Q8K2V6-2; Sequence=VSP_010935; Belongs to the importin beta family. fibrillar center protein binding nucleus nuclear envelope cytoplasm cytosol protein import into nucleus ribosomal protein import into nucleus intracellular protein transport Ran GTPase binding protein transport nuclear import signal receptor activity uc007rtx.1 uc007rtx.2 uc007rtx.3 
ENSMUST00000080859.8 H3c8 ENSMUST00000080859.8 H3 clustered histone 8 (from RefSeq NM_145073.2) ENSMUST00000080859.1 ENSMUST00000080859.2 ENSMUST00000080859.3 ENSMUST00000080859.4 ENSMUST00000080859.5 ENSMUST00000080859.6 ENSMUST00000080859.7 H3.1-221 H3.1-291 H3.1-I H31_MOUSE H3a H3c1 H3c10 H3c11 H3c8 H3g H3h H3i Hist1h3a Hist1h3g Hist1h3h Hist1h3i NM_145073 P02295 P02296 P16106 P68433 Q05A97 Q3B7Z8 Q3B7Z9 Q5T009 uc007ptx.1 uc007ptx.2 uc007ptx.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC125355.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with TONSL; CHAF1A; CHAF1B; MCM2 and DNAJC9 (By similarity). P68433; P83917: Cbx1; NbExp=6; IntAct=EBI-79743, EBI-78119; P68433; Q8WTS6: SETD7; Xeno; NbExp=2; IntAct=EBI-79743, EBI-1268586; Nucleus. Chromosome. Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity). Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys- 10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. This histone is only present in mammals. Belongs to the histone H3 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly macromolecular complex protein heterodimerization activity protein heterotetramerization regulation of gene silencing uc007ptx.1 uc007ptx.2 uc007ptx.3 
ENSMUST00000080860.13 Ccdc28a ENSMUST00000080860.13 coiled-coil domain containing 28A, transcript variant 1 (from RefSeq NM_144820.4) Ccdc28a ENSMUST00000080860.1 ENSMUST00000080860.10 ENSMUST00000080860.11 ENSMUST00000080860.12 ENSMUST00000080860.2 ENSMUST00000080860.3 ENSMUST00000080860.4 ENSMUST00000080860.5 ENSMUST00000080860.6 ENSMUST00000080860.7 ENSMUST00000080860.8 ENSMUST00000080860.9 NM_144820 Q3UFK1 Q3UFK1_MOUSE uc007eme.1 uc007eme.2 uc007eme.3 molecular_function cellular_component biological_process uc007eme.1 uc007eme.2 uc007eme.3 
ENSMUST00000080861.6 Rpl35 ENSMUST00000080861.6 ribosomal protein L35 (from RefSeq NM_025592.3) ENSMUST00000080861.1 ENSMUST00000080861.2 ENSMUST00000080861.3 ENSMUST00000080861.4 ENSMUST00000080861.5 NM_025592 Q6ZWV7 RL35_MOUSE uc008jnz.1 uc008jnz.2 uc008jnz.3 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Cytoplasm Belongs to the universal ribosomal protein uL29 family. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) mRNA binding structural constituent of ribosome ribosome translation cytosolic large ribosomal subunit ribonucleoprotein complex binding uc008jnz.1 uc008jnz.2 uc008jnz.3 
ENSMUST00000080880.12 Dab2 ENSMUST00000080880.12 disabled 2, mitogen-responsive phosphoprotein, transcript variant 1 (from RefSeq NM_023118.5) A0A0R4J104 A0A0R4J104_MOUSE Dab2 ENSMUST00000080880.1 ENSMUST00000080880.10 ENSMUST00000080880.11 ENSMUST00000080880.2 ENSMUST00000080880.3 ENSMUST00000080880.4 ENSMUST00000080880.5 ENSMUST00000080880.6 ENSMUST00000080880.7 ENSMUST00000080880.8 ENSMUST00000080880.9 NM_023118 uc007vde.1 uc007vde.2 uc007vde.3 uc007vde.4 fibrillar center positive regulation of protein phosphorylation plasma membrane clathrin-coated pit endocytosis protein C-terminus binding positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation vesicle-mediated transport clathrin-coated vesicle positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process leading edge cell differentiation clathrin adaptor activity cargo receptor activity negative regulation of apoptotic process intracellular membrane-bounded organelle positive regulation of endocytosis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated SMAD binding positive regulation of SMAD protein import into nucleus negative regulation of androgen receptor signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of protein localization to plasma membrane positive regulation of Wnt signaling pathway, planar cell polarity pathway positive regulation of clathrin-dependent endocytosis positive regulation of early endosome to late endosome transport uc007vde.1 uc007vde.2 uc007vde.3 uc007vde.4 
ENSMUST00000080885.12 Dbp ENSMUST00000080885.12 D site albumin promoter binding protein, transcript variant 1 (from RefSeq NM_016974.4) DBP_MOUSE ENSMUST00000080885.1 ENSMUST00000080885.10 ENSMUST00000080885.11 ENSMUST00000080885.2 ENSMUST00000080885.3 ENSMUST00000080885.4 ENSMUST00000080885.5 ENSMUST00000080885.6 ENSMUST00000080885.7 ENSMUST00000080885.8 ENSMUST00000080885.9 NM_016974 Q60925 Q8VCX3 uc009gws.1 uc009gws.2 uc009gws.3 uc009gws.4 The protein encoded by this gene is a member of the Par bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, Cyp2a4, and Cyp2a5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythym genes. [provided by RefSeq, Feb 2014]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK140243.1, BC018323.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation (By similarity). Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF (By similarity). Nucleus. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity. Accumulates according to a robust circadian rhythm in liver and kidney. In liver nuclei, the amplitude of daily oscillation has been estimated to be >50-fold, and 2-fold in the brain. Mice deficient for all three PAR bZIP proteins (DBP, HLF and TEF) display a dramatically shortened life span and are highly susceptible to generalized spontaneous and audiogenic epilepsies (due for example to the noise of a vacuum cleaner) that are frequently lethal. The down-regulation of pyridoxal kinase (Pdxk) expression in these mice may participate in this seizure phenotype. Belongs to the bZIP family. PAR subfamily. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding liver development DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter circadian rhythm positive regulation of transcription from RNA polymerase II promoter rhythmic process uc009gws.1 uc009gws.2 uc009gws.3 uc009gws.4 
ENSMUST00000080891.6 Gm6578 ENSMUST00000080891.6 predicted gene 6578 (from RefSeq NR_003631.2) ENSMUST00000080891.1 ENSMUST00000080891.2 ENSMUST00000080891.3 ENSMUST00000080891.4 ENSMUST00000080891.5 NR_003631 uc029vtj.1 uc029vtj.2 uc029vtj.3 uc029vtj.4 uc029vtj.1 uc029vtj.2 uc029vtj.3 uc029vtj.4 
ENSMUST00000080893.7 Krt17 ENSMUST00000080893.7 keratin 17 (from RefSeq NM_010663.3) A2A4G6 ENSMUST00000080893.1 ENSMUST00000080893.2 ENSMUST00000080893.3 ENSMUST00000080893.4 ENSMUST00000080893.5 ENSMUST00000080893.6 K1C17_MOUSE Krt1-17 NM_010663 Q61783 Q9QWL7 uc007lks.1 uc007lks.2 uc007lks.3 uc007lks.4 The protein encoded by this gene is a member of the type I keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin required for the normal growth of hair follicles and may act in psoriasis as an immunopathogenic autoantigen. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB013608.1, BC132454.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (PubMed:14714564, PubMed:16702408). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (PubMed:16702408). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (PubMed:16710422). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (PubMed:20871598). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers (KRT6A or KRT6B) (By similarity). Interacts with TRADD and SFN. Q9QWL7; O70456: Sfn; NbExp=3; IntAct=EBI-309015, EBI-1544118; Cytoplasm Expressed strongly in outer root sheath and medulla region of hair follicle and in the early differentiating epithelial cells (trichocytes) within the hair bulb region. Weak expression in the matrix cells of hair bulb. Also present in the sweat gland within the skin, vibrissae follicle, salivary gland, tooth and thymus. Expression first occurs in a subset of epithelial cells within the single-layered, undifferentiated ectoderm of embryonic day 10.5 mouse fetuses (PubMed:9786956). In the ensuing 48 hours, K17- expressing cells give rise to placodes, the precursors of ectoderm- derived appendages (hair, glands, and tooth), and to periderm (PubMed:9786956). Expressed in hair follicles and in the basal and suprabasal layers of the interfollicular epidermis at birth (PubMed:11408584). Induced in damaged or stressed epidermis and by interferon- gamma. Up-regulated by LEF1. Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization. Severe alopecia during the first week postbirth, correlating with hair fragility, alterations in follicular histology, and apoptosis in matrix cells. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. morphogenesis of an epithelium structural molecule activity protein binding cytoplasm intermediate filament signal transduction positive regulation of cell growth hair follicle morphogenesis keratinization MHC class II receptor activity MHC class II protein binding intermediate filament organization intermediate filament cytoskeleton positive regulation of translation positive regulation of hair follicle development cell periphery uc007lks.1 uc007lks.2 uc007lks.3 uc007lks.4 
ENSMUST00000080898.4 Amd2 ENSMUST00000080898.4 S-adenosylmethionine decarboxylase 2 (from RefSeq NM_007444.3) Amd-2 D3Z6H8 DCAM2_MOUSE ENSMUST00000080898.1 ENSMUST00000080898.2 ENSMUST00000080898.3 NM_007444 P82184 Q58E47 uc033fpd.1 uc033fpd.2 uc033fpd.3 uc033fpd.4 Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. Reaction=H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3- (methylsulfanyl)propylamine; Xref=Rhea:RHEA:15981, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57443, ChEBI:CHEBI:59789; EC=4.1.1.50; Evidence=; Name=pyruvate; Xref=ChEBI:CHEBI:15361; Note=Binds 1 pyruvoyl group covalently per subunit.; Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1. Heterotetramer of two alpha and two beta chains. Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. Belongs to the eukaryotic AdoMetDC family. Product of an intronless, probably retrotransposed, copy of AMD1. mRNA levels are 10-40 times lower than AMD1 (PubMed:9620866). adenosylmethionine decarboxylase activity cytosol S-adenosylmethioninamine biosynthetic process polyamine biosynthetic process spermine biosynthetic process spermidine biosynthetic process lyase activity carboxy-lyase activity putrescine binding uc033fpd.1 uc033fpd.2 uc033fpd.3 uc033fpd.4 
ENSMUST00000080911.3 C030014I23Rik ENSMUST00000080911.3 C030014I23Rik (from geneSymbol) ENSMUST00000080911.1 ENSMUST00000080911.2 uc292gqe.1 uc292gqe.2 uc292gqe.3 uc292gqe.1 uc292gqe.2 uc292gqe.3 
ENSMUST00000080919.12 Thrap3 ENSMUST00000080919.12 thyroid hormone receptor associated protein 3, transcript variant 1 (from RefSeq NM_146153.3) ENSMUST00000080919.1 ENSMUST00000080919.10 ENSMUST00000080919.11 ENSMUST00000080919.2 ENSMUST00000080919.3 ENSMUST00000080919.4 ENSMUST00000080919.5 ENSMUST00000080919.6 ENSMUST00000080919.7 ENSMUST00000080919.8 ENSMUST00000080919.9 NM_146153 Q569Z6 TR150_MOUSE Trap150 uc008usv.1 uc008usv.2 uc008usv.3 uc008usv.4 Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin- D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). Associated with the large multiprotein complex TRAP (Mediator complex-like). Interacts with SFPQ; the interaction is dependent on SFPQ phosphorylation at 'Thr-687' and inhibits binding of SFPQ to an ESS1 exonic splicing silencer element-containing RNA. Interacts with NXF1. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Associated with spliced mRNP complexes. Interacts with HELZ2 and PPARG. Interacts with CLOCK and BMAL1 (By similarity). Component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3 (By similarity). Nucleus Nucleus, nucleoplasm Nucleus speckle Expressed in a circadian manner in the liver with a peak at approximately circadian time (CT) 8 hours (at protein level). Belongs to the BCLAF1/THRAP3 family. nucleotide binding regulation of alternative mRNA splicing, via spliceosome nuclear-transcribed mRNA catabolic process RNA polymerase II distal enhancer sequence-specific DNA binding transcription cofactor activity transcription coactivator activity protein binding ATP binding nucleus nucleoplasm transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter mRNA processing circadian rhythm RNA splicing mediator complex nuclear speck ligand-dependent nuclear receptor transcription coactivator activity exon-exon junction complex positive regulation of circadian rhythm positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter thyroid hormone receptor binding positive regulation of mRNA splicing, via spliceosome mRNA stabilization rhythmic process phosphoprotein binding uc008usv.1 uc008usv.2 uc008usv.3 uc008usv.4 
ENSMUST00000080925.7 Or2ag20 ENSMUST00000080925.7 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EPF6) E9PZZ5 ENSMUST00000080925.1 ENSMUST00000080925.2 ENSMUST00000080925.3 ENSMUST00000080925.4 ENSMUST00000080925.5 ENSMUST00000080925.6 Olfr695 Olfr698 Olfr704 Or2ag20 Q9EPF6 Q9EPF6_MOUSE uc291ucy.1 uc291ucy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ucy.1 uc291ucy.2 
ENSMUST00000080926.13 Eno1 ENSMUST00000080926.13 enolase 1, alpha non-neuron, transcript variant 3 (from RefSeq NM_023119.2) EG433182 ENSMUST00000080926.1 ENSMUST00000080926.10 ENSMUST00000080926.11 ENSMUST00000080926.12 ENSMUST00000080926.2 ENSMUST00000080926.3 ENSMUST00000080926.4 ENSMUST00000080926.5 ENSMUST00000080926.6 ENSMUST00000080926.7 ENSMUST00000080926.8 ENSMUST00000080926.9 Eno1 NM_023119 Q5FW97 Q5FW97_MOUSE Q5XJG8 Q5XKE1 uc008vxp.1 uc008vxp.2 uc008vxp.3 uc008vxp.4 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 4/5. Belongs to the enolase family. phosphopyruvate hydratase complex magnesium ion binding phosphopyruvate hydratase activity glycolytic process uc008vxp.1 uc008vxp.2 uc008vxp.3 uc008vxp.4 
ENSMUST00000080929.13 Nxf3 ENSMUST00000080929.13 nuclear RNA export factor 3 (from RefSeq NM_001024141.4) ENSMUST00000080929.1 ENSMUST00000080929.10 ENSMUST00000080929.11 ENSMUST00000080929.12 ENSMUST00000080929.2 ENSMUST00000080929.3 ENSMUST00000080929.4 ENSMUST00000080929.5 ENSMUST00000080929.6 ENSMUST00000080929.7 ENSMUST00000080929.8 ENSMUST00000080929.9 NM_001024141 NXF3 Nxf3 Q4ZGD9 Q4ZGD9_MOUSE uc009uib.1 uc009uib.2 Cytoplasm nucleic acid binding RNA binding mRNA binding protein binding nucleus nucleoplasm cytoplasm mRNA export from nucleus poly(A)+ mRNA export from nucleus nuclear RNA export factor complex mRNA transport uc009uib.1 uc009uib.2 
ENSMUST00000080932.8 Fes ENSMUST00000080932.8 feline sarcoma oncogene (from RefSeq NM_010194.2) ENSMUST00000080932.1 ENSMUST00000080932.2 ENSMUST00000080932.3 ENSMUST00000080932.4 ENSMUST00000080932.5 ENSMUST00000080932.6 ENSMUST00000080932.7 FES_MOUSE Fps NM_010194 P16879 Q3TD20 Q62122 Q8CG02 uc009iat.1 uc009iat.2 Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Kinase activity is tightly regulated. Activated in response to signaling from a cell surface receptor. Activation probably requires binding of a substrate via the SH2 domain, plus autophosphorylation at Tyr-713. Present in an inactive form in the absence of activating stimuli. Homooligomer. Interacts with BCR. Interacts (when activated, via coiled coil domain) with TRIM28. Interacts (via SH2 domain) with phosphorylated EZR, MS4A2/FCER1B and HCLS1/HS1. Interacts with phosphorylated KIT. Interacts with FLT3. Interacts (via F-BAR domain) with soluble tubulin. Interacts (via SH2 domain) with microtubules (By similarity). P16879; P01901: H2-K1; NbExp=3; IntAct=EBI-771815, EBI-1265227; P16879; P35235: Ptpn11; NbExp=2; IntAct=EBI-771815, EBI-397236; Cytoplasm, cytosol Cytoplasm, cytoskeleton Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle Golgi apparatus Cell junction, focal adhesion Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery (By similarity). The coiled coil domains are important for regulating the kinase activity. They mediate homooligomerization and probably also interaction with other proteins (By similarity). The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes. Autophosphorylated on Tyr-713 in response to FGF2. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK (By similarity). No visible phenotype. Mice are fertile and healthy, display slightly reduced numbers of myeloid cells and are more sensitive to lipopolysaccharide (LPS). Mice lacking both Fps/Fes and Fer activity are viable and fertile, but produce fewer offspring than normal. They display elevated levels of circulating neutrophils, erythrocytes and platelets, while other cell counts are normal. In a BRAF V600E-driven, PTEN deficient and FES deficient melanoma model, tumor growth is accelerated due to an increased proliferation of melanoma cells. Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. nucleotide binding microtubule bundle formation protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding cytoplasm Golgi apparatus cytosol cytoskeleton plasma membrane focal adhesion protein phosphorylation chemotaxis centrosome cycle cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway microtubule binding lipid binding regulation of cell shape positive regulation of neuron projection development microtubule cytoskeleton membrane kinase activity phosphorylation cell migration transferase activity peptidyl-tyrosine phosphorylation cell junction cell differentiation regulation of cell adhesion positive regulation of microtubule polymerization extrinsic component of cytoplasmic side of plasma membrane cytoplasmic vesicle immunoglobulin receptor binding phosphatidylinositol binding peptidyl-tyrosine autophosphorylation regulation of cell proliferation regulation of mast cell degranulation regulation of cell differentiation positive regulation of myeloid cell differentiation positive regulation of monocyte differentiation protein autophosphorylation cellular response to vitamin D regulation of cell motility positive regulation of actin cytoskeleton reorganization uc009iat.1 uc009iat.2 
ENSMUST00000080953.12 Lrp2 ENSMUST00000080953.12 low density lipoprotein receptor-related protein 2 (from RefSeq NM_001081088.2) A2ARV4 ENSMUST00000080953.1 ENSMUST00000080953.10 ENSMUST00000080953.11 ENSMUST00000080953.2 ENSMUST00000080953.3 ENSMUST00000080953.4 ENSMUST00000080953.5 ENSMUST00000080953.6 ENSMUST00000080953.7 ENSMUST00000080953.8 ENSMUST00000080953.9 LRP2_MOUSE NM_001081088 P70215 Q3TL35 Q9JLB3 uc008jyc.1 uc008jyc.2 uc008jyc.3 Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins (PubMed:10766831). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (PubMed:22841573). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (PubMed:24825475). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (PubMed:17462596). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (PubMed:10052453). Mediates renal uptake of metallothionein-bound heavy metals (By similarity). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (PubMed:18174160). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (PubMed:28659595). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (PubMed:15623804). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (PubMed:22340494). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (PubMed:24639464). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (PubMed:20460439). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (PubMed:20637285). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (PubMed:22354480). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (PubMed:26439398). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (PubMed:16143106). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensin 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (PubMed:26822476). Required for normal hearing, possibly through interaction with estrogen in the inner ear (PubMed:17846082). Binds plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin, CLU/clusterin and calcium. Forms a multimeric complex together with LRPAP1 (By similarity). Interacts (via PxLPxI/L motif) with ANKRA2 (via ankyrin repeats) (By similarity). Interacts with LRP2BP. Interacts (via NPXY motif) with DAB2; the interaction is not affected by tyrosine phosphorylation of the NPXY motif (PubMed:11247302). Interacts with MB (By similarity). Interacts with BMP4 (PubMed:15623804). Interacts with the Sonic hedgehog protein N-product which is the active product of SHH (PubMed:11964399). Interacts with CST3 in a calcium-dependent manner (By similarity). Interacts with the vitamin-D binding protein GC/DBP (PubMed:10052453). Interacts with sex hormone-binding protein SHBG (By similarity). Interacts with angiotensin-2 (PubMed:15467006). Also interacts with angiotensin 1-7 (PubMed:16380466). Interacts with APOM (PubMed:16099815). Interacts with selenoprotein SEPP1 (PubMed:18174160). Interacts with LEP (By similarity). Interacts with ALB (By similarity). Interacts with the antiapoptotic protein BIRC5/survivin (By similarity). Interacts with matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). In neurons, forms a trimeric complex with APP and APPB1/FE65 (PubMed:20637285). Interacts with LDLRAP1/ARH; mediates trafficking of LRP2 to the endocytic recycling compartment (By similarity). Does not interact with beta-amyloid protein 40 alone but interacts with the complex composed of beta-amyloid protein 40 and CLU/APOJ (By similarity). Interacts with MDK (PubMed:10772929). A2ARV4; P97318: Dab1; NbExp=2; IntAct=EBI-300875, EBI-81680; A2ARV4; Q62108: Dlg4; NbExp=2; IntAct=EBI-300875, EBI-300895; A2ARV4; Q9Z0G0: Gipc1; NbExp=2; IntAct=EBI-300875, EBI-300855; A2ARV4; Q9WVI9: Mapk8ip1; NbExp=2; IntAct=EBI-300875, EBI-74515; A2ARV4; Q9ERE9: Mapk8ip2; NbExp=2; IntAct=EBI-300875, EBI-74576; A2ARV4; Q9D6K5: Synj2bp; NbExp=2; IntAct=EBI-300875, EBI-300910; Apical cell membrane ingle-pass type I membrane protein Endosome lumen Membrane, coated pit Cell projection, dendrite Cell projection, axon Note=Localizes to brush border membranes in the kidney. In the endolymphatic sac of the inner ear, located in the lumen of endosomes as a soluble form. In the inner ear, strongly expressed in the marginal cells of the stria vascularis (at protein level) (PubMed:17846082). In the female reproductive tract, expressed on the luminal side of the uterine epithelium (at protein level) (PubMed:16143106). In the adult brain, expressed in ependymal cells of the lateral ventricles where expression is restricted to the ependyma that faces the stem cell niche (at protein level) (PubMed:20460439). Expressed in neurons throughout the brain including in the hippocampus, limbic cortices and cerebellum (at protein level) (PubMed:20637285). In the developing optic nerve, expressed exclusively in astrocytes at 14.5 dpc, 16.5 dpc and 18.5 dpc (at protein level) (PubMed:22354480). In the developing optic nerve, more strongly expressed at 14.5 dpc and 16.5 dpc than at 18.5 dpc (at protein level) (PubMed:22354480). In the embryo, expression is detected from 7.5 dpc on the apical side of the developing neural plate and persists throughout later stages of development (PubMed:22340494). After neural tube closure at 9.5 dpc, becomes progressively restricted to the midline region (PubMed:22340494). During the estrus cycle, expression is highest in metestrus II and diestrus (PubMed:16143106). Down-regulated in the kidney by cannabinoids, such as endocannabinoid anandamide and synthetic cannabinoid HU-210. Two overlapping PxLPxI/L motifs mediate interaction with ankyrin repeats of ANKRA2. The cytoplasmic domain is required for sorting to the apical cell membrane. A fraction undergoes proteolytic cleavage of the extracellular domain at the cell membrane to generate a cytoplasmic tail fragment. This is internalized into the early endosome from where it trafficks in an LDLRAP1/ARH-dependent manner to the endocytic recycling compartment (ERC). In the ERC, it is further cleaved by gamma-secretase to release a fragment which translocates to the nucleus and mediates transcriptional repression. N-glycosylation is required for ligand binding. Contains core- fucosylated N-glycans in kidney proximal convoluted tubules (PCTs) and hybrid-type N-glycans in proximal straight tubules (PSTs). Interacts with ligands in a glycoform-dependent manner. Retinol-binding protein and the vitamin D carrier GC/DBP are endocytosed primarily by PCTs, albumin is endocytosed equally by PCTs and PSTs, and the aminoglycoside kanamycin is endocytosed primarily by PSTs. Severe facial dysgenesis and impaired forebrain development around mid-gestation, absence of Shh expression and decreased cell proliferation in the ventral neural tube, and aberrant expression of morphogens Fgf8 and Bmp4 (PubMed:15623804). Reduced expression of homeobox protein Six3 at 8.0 dpc in the prospective forebrain and impaired Shh expression at the ventral midline with resulting midline formation defects and holoprosencephaly (PubMed:22340494). At 9.5 dpc, loss of Shh in the ventral anterior diencephalon and increased Bmp4 expression in the dorsal forebrain (PubMed:22340494). Increased Bmp4 expression and impaired proliferation of neural precursor cells in the subependymal zone of the brain which results in decreased numbers of neuroblasts reaching the olfactory bulb (PubMed:20460439). Compound heterozygotes display enlarged and exophthalmic eyes with thinning of the retina (PubMed:26439398). Severe cardiovascular abnormalities including aortic arch anomalies, persistent truncus arteriosus with coronary artery anomalies, ventricular septal defects, overriding of the tricuspid valve, marked thinning of the ventricular myocardium, and abnormal positioning of the neural crest cells and second heart field (PubMed:26822476). Impaired endocytosis of folate bound to the folate receptor FOLR1, reduced folate levels in embryos and impaired closure of the rostral neural tube (PubMed:24639464). High lethality at and after birth with survivors showing profound hearing loss, elevated lipofuscin granule levels and irregular apical surfaces in marginal cells of the stria vascularis, complete loss of potassium ion channel KCQN1 in basal and midbasal cochlear turns, and reduced estrogen uptake in the stria vascularis (PubMed:17846082). Survivors also display severe vitamin D deficiency and bone formation defects (PubMed:10052453). Failure of the vaginal cavity to open after birth in females and impaired testis descent in males with the left testis poorly developed and severely retarded in size (PubMed:16143106). Conditional knockout in the kidney results in reduced expression of CUBN in kidney cells and little or no uptake of myoglobin (PubMed:12724130). It also results in reduced uptake of Cst3 by kidney proximal tubule cells (PubMed:17462596). In addition, it causes pronounced urinary excretion of Apom, Birc5/survivin, and Mmp2 together with Timp1 (PubMed:16099815, PubMed:23825075, PubMed:28659595). Belongs to the LDLR family. neural tube closure secondary heart field specification outflow tract septum morphogenesis ventricular compact myocardium morphogenesis ventricular septum development calcium ion binding protein binding extracellular space cytoplasm endosome endoplasmic reticulum Golgi apparatus plasma membrane brush border clathrin-coated pit vitamin metabolic process endocytosis receptor-mediated endocytosis nervous system development heart development sensory perception of sound drug binding cell proliferation male gonad development external side of plasma membrane cell surface response to X-ray membrane integral component of membrane endosomal transport apical plasma membrane SH3 domain binding hemoglobin import metal ion transport endocytic vesicle PDZ domain binding axon dendrite hemoglobin binding negative regulation of BMP signaling pathway forebrain development brush border membrane endosome lumen macromolecular complex steroid hormone receptor binding aorta development hormone binding cell projection negative regulation of apoptotic process receptor complex axonal growth cone macromolecular complex binding transcytosis membrane raft apical part of cell positive regulation of endocytosis metal ion binding hormone secretion low-density lipoprotein particle receptor binding positive regulation of neurogenesis chaperone binding positive regulation of protein kinase B signaling vagina development coronary vasculature development coronary artery morphogenesis pulmonary artery morphogenesis chemoattraction of axon positive regulation of oligodendrocyte progenitor proliferation folic acid import into cell uc008jyc.1 uc008jyc.2 uc008jyc.3 
ENSMUST00000080975.6 Os9 ENSMUST00000080975.6 amplified in osteosarcoma, transcript variant 2 (from RefSeq NM_177614.3) ENSMUST00000080975.1 ENSMUST00000080975.2 ENSMUST00000080975.3 ENSMUST00000080975.4 ENSMUST00000080975.5 NM_177614 OS9_MOUSE Q8K2C7 uc007hhz.1 uc007hhz.2 uc007hhz.3 uc007hhz.4 Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 (By similarity). Interacts (via C-terminus) with CPNE6 (via second C2 domain); this interaction occurs in a calcium-dependent manner in vitro (PubMed:10403379). Component of the HRD1 complex, which comprises at least SYNV1/HRD1, DERL1/2, FAM8A1, HERPUD1/HERP, OS9, SEL1L and UBE2J1. FAM8A1 is stabilized by interaction with SYNV1, which prevents its proteasomal degradation. OS9 and UBE2J1 recruitment to the complex may be mediated by SEL1L (By similarity). Through this complex, may interact with ERLEC1 and HSPA5 (By similarity). Interacts with HSP90B1 (By similarity). Interacts with CREB3 (By similarity). Endoplasmic reticulum lumen Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2C7-1; Sequence=Displayed; Name=2; IsoId=Q8K2C7-2; Sequence=VSP_038220; Intramolecular disulfide bonds. N-glycosylated. Belongs to the OS-9 family. protease binding protein binding endoplasmic reticulum endoplasmic reticulum lumen ubiquitin-dependent protein catabolic process protein targeting protein retention in ER lumen protein ubiquitination carbohydrate binding ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol response to endoplasmic reticulum stress negative regulation of retrograde protein transport, ER to cytosol uc007hhz.1 uc007hhz.2 uc007hhz.3 uc007hhz.4 
ENSMUST00000080995.8 Tmem26 ENSMUST00000080995.8 transmembrane protein 26 (from RefSeq NM_177794.3) ENSMUST00000080995.1 ENSMUST00000080995.2 ENSMUST00000080995.3 ENSMUST00000080995.4 ENSMUST00000080995.5 ENSMUST00000080995.6 ENSMUST00000080995.7 NM_177794 Q149T3 Q3UP23 Q8BN94 TMM26_MOUSE uc007fmm.1 uc007fmm.2 uc007fmm.3 uc007fmm.4 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007fmm.1 uc007fmm.2 uc007fmm.3 uc007fmm.4 
ENSMUST00000081007.7 Krtap4-1 ENSMUST00000081007.7 keratin associated protein 4-1 (from RefSeq NM_001048196.1) ENSMUST00000081007.1 ENSMUST00000081007.2 ENSMUST00000081007.3 ENSMUST00000081007.4 ENSMUST00000081007.5 ENSMUST00000081007.6 Krtap4-1 NM_001048196 Q3UUY3 Q3UUY3_MOUSE uc007ljh.1 uc007ljh.2 uc007ljh.3 molecular_function cellular_component intermediate filament biological_process keratin filament uc007ljh.1 uc007ljh.2 uc007ljh.3 
ENSMUST00000081017.3 Defb4 ENSMUST00000081017.3 defensin beta 4 (from RefSeq NM_019728.4) Defb4 ENSMUST00000081017.1 ENSMUST00000081017.2 NM_019728 Q499H9 Q499H9_MOUSE uc009laj.1 uc009laj.2 uc009laj.3 uc009laj.4 Secreted extracellular region defense response uc009laj.1 uc009laj.2 uc009laj.3 uc009laj.4 
ENSMUST00000081022.9 Zfp28 ENSMUST00000081022.9 zinc finger protein 28 (from RefSeq NM_175247.3) ENSMUST00000081022.1 ENSMUST00000081022.2 ENSMUST00000081022.3 ENSMUST00000081022.4 ENSMUST00000081022.5 ENSMUST00000081022.6 ENSMUST00000081022.7 ENSMUST00000081022.8 Mkr5 NM_175247 P10078 Q61776 Q8BT11 Q8C836 ZFP28_MOUSE Zfp-28 uc009fbi.1 uc009fbi.2 uc009fbi.3 May be involved in transcriptional regulation. May have a role in embryonic development. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P10078-1; Sequence=Displayed; Name=2; IsoId=P10078-2; Sequence=VSP_006882; Expressed predominantly in ovary. Expression decreases in embryo after day 16. Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009fbi.1 uc009fbi.2 uc009fbi.3 
ENSMUST00000081028.13 Etv6 ENSMUST00000081028.13 ets variant 6, transcript variant 1 (from RefSeq NM_007961.4) ENSMUST00000081028.1 ENSMUST00000081028.10 ENSMUST00000081028.11 ENSMUST00000081028.12 ENSMUST00000081028.2 ENSMUST00000081028.3 ENSMUST00000081028.4 ENSMUST00000081028.5 ENSMUST00000081028.6 ENSMUST00000081028.7 ENSMUST00000081028.8 ENSMUST00000081028.9 ETV6_MOUSE NM_007961 P97360 Tel Tel1 uc009eke.1 uc009eke.2 uc009eke.3 uc009eke.4 uc009eke.5 This gene encodes a transcriptional repressor belonging to the ETS family of proteins. Knockout of this gene in mice results in embryonic lethality due to defective angiogenesis. In humans, this gene is often involved in chromosome rearrangements associated with specific cancers. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]. Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9 (By similarity). Nucleus Belongs to the ETS family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleolus cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter vitellogenesis protein domain specific binding neurogenesis cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter hematopoietic stem cell proliferation mesenchymal cell apoptotic process uc009eke.1 uc009eke.2 uc009eke.3 uc009eke.4 uc009eke.5 
ENSMUST00000081035.10 Mpeg1 ENSMUST00000081035.10 macrophage expressed gene 1, transcript variant 1 (from RefSeq NM_010821.2) E9QN37 E9QN37_MOUSE ENSMUST00000081035.1 ENSMUST00000081035.2 ENSMUST00000081035.3 ENSMUST00000081035.4 ENSMUST00000081035.5 ENSMUST00000081035.6 ENSMUST00000081035.7 ENSMUST00000081035.8 ENSMUST00000081035.9 Mpeg1 NM_010821 uc008gub.1 uc008gub.2 uc008gub.3 uc008gub.4 uc008gub.5 Cytoplasmic vesicle membrane ; Multi-pass membrane protein Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the MPEG1 family. membrane integral component of membrane uc008gub.1 uc008gub.2 uc008gub.3 uc008gub.4 uc008gub.5 
ENSMUST00000081064.12 Cenpi ENSMUST00000081064.12 centromere protein I, transcript variant 1 (from RefSeq NM_145924.3) CENPI_MOUSE ENSMUST00000081064.1 ENSMUST00000081064.10 ENSMUST00000081064.11 ENSMUST00000081064.2 ENSMUST00000081064.3 ENSMUST00000081064.4 ENSMUST00000081064.5 ENSMUST00000081064.6 ENSMUST00000081064.7 ENSMUST00000081064.8 ENSMUST00000081064.9 Fshprh1 NM_145924 Q8BXU9 Q8K1K4 uc009ufu.1 uc009ufu.2 uc009ufu.3 uc009ufu.4 This gene encodes a protein that may be constitutively associated with centromeres and might be involved in recruiting centromere protein A to the centromere for kinetochore assembly. A similar gene in human is involved in the response of gonadal tissues to follicle-stimulating hormone. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle- stimulating hormone (By similarity). Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts with SENP6 (By similarity). Nucleus Chromosome, centromere Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity). Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation (By similarity). Belongs to the CENP-I/CTF3 family. chromosome, centromeric region kinetochore molecular_function nucleus chromosome cytosol biological_process nuclear body centromere complex assembly uc009ufu.1 uc009ufu.2 uc009ufu.3 uc009ufu.4 
ENSMUST00000081074.5 Dmtf1l ENSMUST00000081074.5 cyclin D binding myb like transcription factor 1 like (from RefSeq NM_177705.3) 4932411N23Rik Dmtf1l ENSMUST00000081074.1 ENSMUST00000081074.2 ENSMUST00000081074.3 ENSMUST00000081074.4 NM_177705 Q8C0S0 Q8C0S0_MOUSE uc033jsj.1 uc033jsj.2 uc033jsj.3 RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding nucleoplasm uc033jsj.1 uc033jsj.2 uc033jsj.3 
ENSMUST00000081079.6 Entpd7 ENSMUST00000081079.6 ectonucleoside triphosphate diphosphohydrolase 7 (from RefSeq NM_053103.5) B9EHD3 ENSMUST00000081079.1 ENSMUST00000081079.2 ENSMUST00000081079.3 ENSMUST00000081079.4 ENSMUST00000081079.5 ENTP7_MOUSE Kiaa4066 Lalp1 NM_053103 Q3TCT4 Q3TM04 Q571A5 Q9ET10 uc008hos.1 uc008hos.2 uc008hos.3 uc008hos.4 Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Preferentially hydrolyzes nucleoside 5'-triphosphates, with substrate preference for UTP > GTP > CTP. Hydrolyzes nucleoside diphosphates only to a minor extent (By similarity). In contrast to its human ortholog is able to hydrolyze ATP. In the epithelial cells of small intestine controls luminal ATP levels, therefore regulating Th17-cell development (PubMed:23241884). Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15; Evidence=; Reaction=H2O + UTP = H(+) + phosphate + UDP; Xref=Rhea:RHEA:64900, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398, ChEBI:CHEBI:58223; Evidence=; Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; Reaction=CTP + H2O = CDP + H(+) + phosphate; Xref=Rhea:RHEA:29387, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:58069; Evidence=; Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasmic vesicle membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TCT4-1; Sequence=Displayed; Name=2; IsoId=Q3TCT4-2; Sequence=VSP_022743, VSP_022744; Widely expressed. Expressed at high level in brain, kidney, liver, testis and small intestin. Weakly expressed in lung, thymus and heart. Deficient mice are born at the normal Mendelian ratios and grow healthily until 16 week of age. Normal lymphocyte development is observed. However deficient mice shown an increased in ATP concentrations in the small intestinal lumen and increased numbers of IL-17-producing Th17 cells in the small intestinal lamina propria. They show increased resistance to Citrobacter rodentium infection and increased susceptibility to experimental autoimmune encephalomyelitis. Belongs to the GDA1/CD39 NTPase family. nucleus ribonucleoside diphosphate catabolic process ribonucleoside triphosphate catabolic process membrane integral component of membrane hydrolase activity nucleoside-diphosphatase activity nucleoside-triphosphatase activity cytoplasmic vesicle membrane cytoplasmic vesicle metal ion binding uc008hos.1 uc008hos.2 uc008hos.3 uc008hos.4 
ENSMUST00000081095.4 Or8b49 ENSMUST00000081095.4 olfactory receptor family 8 subfamily B member 49 (from RefSeq NM_001011523.2) E9Q716 E9Q716_MOUSE ENSMUST00000081095.1 ENSMUST00000081095.2 ENSMUST00000081095.3 NM_001011523 Olfr913 Or8b49 uc009owt.1 uc009owt.2 uc009owt.3 uc009owt.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB174027.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009owt.1 uc009owt.2 uc009owt.3 uc009owt.4 
ENSMUST00000081103.12 Fcgr2b ENSMUST00000081103.12 Fc receptor, IgG, low affinity IIb, transcript variant 2 (from RefSeq NM_010187.3) A0A0B4J1G1 A0A0B4J1G1_MOUSE ENSMUST00000081103.1 ENSMUST00000081103.10 ENSMUST00000081103.11 ENSMUST00000081103.2 ENSMUST00000081103.3 ENSMUST00000081103.4 ENSMUST00000081103.5 ENSMUST00000081103.6 ENSMUST00000081103.7 ENSMUST00000081103.8 ENSMUST00000081103.9 Fcgr2b NM_010187 uc007dmt.1 uc007dmt.2 uc007dmt.3 uc007dmt.4 uc007dmt.5 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein membrane integral component of membrane uc007dmt.1 uc007dmt.2 uc007dmt.3 uc007dmt.4 uc007dmt.5 
ENSMUST00000081104.10 Timm17a ENSMUST00000081104.10 translocase of inner mitochondrial membrane 17a, transcript variant 2 (from RefSeq NM_011590.2) ENSMUST00000081104.1 ENSMUST00000081104.2 ENSMUST00000081104.3 ENSMUST00000081104.4 ENSMUST00000081104.5 ENSMUST00000081104.6 ENSMUST00000081104.7 ENSMUST00000081104.8 ENSMUST00000081104.9 NM_011590 Q9Z0V8 TI17A_MOUSE Tim17a uc007csz.1 uc007csz.2 uc007csz.3 Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex. The complex also interacts with DNAJC15 (By similarity). Mitochondrion inner membrane; Multi-pass membrane protein. Belongs to the Tim17/Tim22/Tim23 family. nucleoplasm mitochondrion mitochondrial inner membrane mitochondrial inner membrane presequence translocase complex intracellular protein transport positive regulation of protein processing protein transport P-P-bond-hydrolysis-driven protein transmembrane transporter activity membrane integral component of membrane enzyme binding protein import into mitochondrial matrix integral component of mitochondrial inner membrane protein transmembrane transporter activity uc007csz.1 uc007csz.2 uc007csz.3 
ENSMUST00000081111.14 Impdh2 ENSMUST00000081111.14 inosine monophosphate dehydrogenase 2, transcript variant 2 (from RefSeq NM_011830.5) ENSMUST00000081111.1 ENSMUST00000081111.10 ENSMUST00000081111.11 ENSMUST00000081111.12 ENSMUST00000081111.13 ENSMUST00000081111.2 ENSMUST00000081111.3 ENSMUST00000081111.4 ENSMUST00000081111.5 ENSMUST00000081111.6 ENSMUST00000081111.7 ENSMUST00000081111.8 ENSMUST00000081111.9 IMPDH Impdh2 NM_011830 Q3UAT9 Q3UAT9_MOUSE uc009rqg.1 uc009rqg.2 uc009rqg.3 uc009rqg.4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Reaction=H2O + IMP + NAD(+) = H(+) + NADH + XMP; Xref=Rhea:RHEA:11708, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57464, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58053; EC=1.1.1.205; Evidence= Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence=; Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. Homotetramer. Cytoplasm, cytosol Cytoplasm cleus Belongs to the IMPDH/GMPR family. Lacks conserved residue(s) required for the propagation of feature annotation. nucleotide binding catalytic activity IMP dehydrogenase activity nucleus cytoplasm cytosol purine nucleotide biosynthetic process GMP biosynthetic process circadian rhythm oxidoreductase activity metal ion binding protein homotetramerization oxidation-reduction process retina development in camera-type eye uc009rqg.1 uc009rqg.2 uc009rqg.3 uc009rqg.4 
ENSMUST00000081121.4 Slc24a3 ENSMUST00000081121.4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3, transcript variant 2 (from RefSeq NM_053195.3) ENSMUST00000081121.1 ENSMUST00000081121.2 ENSMUST00000081121.3 NM_053195 Q8VD29 Q8VD29_MOUSE Slc24a3 uc290bbb.1 uc290bbb.2 Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29108; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. plasma membrane ion transport calcium, potassium:sodium antiporter activity membrane integral component of membrane sodium ion transmembrane transport transmembrane transport potassium ion transmembrane transport anion transmembrane transport uc290bbb.1 uc290bbb.2 
ENSMUST00000081133.5 Ct45a ENSMUST00000081133.5 cancer/testis antigen 45 (from RefSeq NM_001033372.2) Ct45a ENSMUST00000081133.1 ENSMUST00000081133.2 ENSMUST00000081133.3 ENSMUST00000081133.4 Gm648 NM_001033372 Q3UJ22 Q3UJ22_MOUSE uc009tgi.1 uc009tgi.2 molecular_function cellular_component biological_process uc009tgi.1 uc009tgi.2 
ENSMUST00000081134.10 Sycp2 ENSMUST00000081134.10 synaptonemal complex protein 2 (from RefSeq NM_177191.3) A2AJW2 ENSMUST00000081134.1 ENSMUST00000081134.2 ENSMUST00000081134.3 ENSMUST00000081134.4 ENSMUST00000081134.5 ENSMUST00000081134.6 ENSMUST00000081134.7 ENSMUST00000081134.8 ENSMUST00000081134.9 NM_177191 Q1G7B6 Q9CUU3 SYCP2_MOUSE Scp2 uc008ohn.1 uc008ohn.2 uc008ohn.3 uc008ohn.4 Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes (PubMed:16717126). Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility (PubMed:16717126). Required for insertion of SYCP3 into synaptonemal complexes (PubMed:16717126). May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements. Component of the lateral elements of synaptonemal complexes (PubMed:16717126). Heterodimer with SYCP3 (PubMed:16717126). Interacts with SMC1A and SMC3 (By similarity). Interacts with TEX11 (PubMed:18316482). Nucleus Chromosome Note=In axial/lateral elements of the tripartite segments of synaptonemal complexes. Detected in testis and spermatocytes (at protein level). Phosphorylated. Mice appear healthy, but males are completely sterile, due to defective meiotic chromosome synapsis during spermatocyte development. Testes weight is much reduced in mutant mice. Females display reduced fertility. Belongs to the SYCP2 family. Sequence=AK014411; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; synaptonemal complex lateral element DNA binding protein binding nucleus nucleoplasm chromosome cell cycle male meiosis female meiotic division fertilization animal organ morphogenesis negative regulation of apoptotic process protein heterodimerization activity male genitalia morphogenesis cell division meiotic cell cycle uc008ohn.1 uc008ohn.2 uc008ohn.3 uc008ohn.4 
ENSMUST00000081154.14 Pikfyve ENSMUST00000081154.14 phosphoinositide kinase, FYVE type zinc finger containing, transcript variant 2 (from RefSeq NM_011086.2) D3Z5N5 D3Z5N5_MOUSE ENSMUST00000081154.1 ENSMUST00000081154.10 ENSMUST00000081154.11 ENSMUST00000081154.12 ENSMUST00000081154.13 ENSMUST00000081154.2 ENSMUST00000081154.3 ENSMUST00000081154.4 ENSMUST00000081154.5 ENSMUST00000081154.6 ENSMUST00000081154.7 ENSMUST00000081154.8 ENSMUST00000081154.9 NM_011086 Pikfyve uc007bhs.1 uc007bhs.2 uc007bhs.3 nucleotide binding 1-phosphatidylinositol-3-phosphate 5-kinase activity ATP binding kinase activity phosphatidylinositol phosphate kinase activity phosphorylation transferase activity intracellular signal transduction phosphatidylinositol metabolic process phosphatidylinositol phosphorylation metal ion binding uc007bhs.1 uc007bhs.2 uc007bhs.3 
ENSMUST00000081170.9 Sgcb ENSMUST00000081170.9 sarcoglycan, beta (dystrophin-associated glycoprotein) (from RefSeq NM_011890.5) ENSMUST00000081170.1 ENSMUST00000081170.2 ENSMUST00000081170.3 ENSMUST00000081170.4 ENSMUST00000081170.5 ENSMUST00000081170.6 ENSMUST00000081170.7 ENSMUST00000081170.8 NM_011890 P82349 Q3TEU9 SGCB_MOUSE uc008xtb.1 uc008xtb.2 uc008xtb.3 Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans. Cell membrane, sarcolemma ; Single-pass type II membrane protein Cytoplasm, cytoskeleton Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts. Disulfide bonds are present. Belongs to the sarcoglycan beta/delta/gamma/zeta family. protein binding cytoplasm cytoskeleton plasma membrane integral component of plasma membrane muscle organ development dystrophin-associated glycoprotein complex dystroglycan complex sarcoglycan complex membrane integral component of membrane sarcolemma muscle fiber development cardiac muscle cell development membrane organization vascular smooth muscle cell development uc008xtb.1 uc008xtb.2 uc008xtb.3 
ENSMUST00000081193.3 5730460C07Rik ENSMUST00000081193.3 RIKEN cDNA 5730460C07 gene (from RefSeq NR_045801.1) ENSMUST00000081193.1 ENSMUST00000081193.2 NR_045801 uc029upg.1 uc029upg.2 uc029upg.3 uc029upg.1 uc029upg.2 uc029upg.3 
ENSMUST00000081202.6 Manbal ENSMUST00000081202.6 mannosidase, beta A, lysosomal-like (from RefSeq NM_026968.3) A2BGN7 A2BGN7_MOUSE ENSMUST00000081202.1 ENSMUST00000081202.2 ENSMUST00000081202.3 ENSMUST00000081202.4 ENSMUST00000081202.5 Manbal NM_026968 uc008noz.1 uc008noz.2 uc008noz.3 Membrane ; Single- pass membrane protein Belongs to the UPF0239 family. membrane integral component of membrane uc008noz.1 uc008noz.2 uc008noz.3 
ENSMUST00000081214.12 Wdr91 ENSMUST00000081214.12 WD repeat domain 91 (from RefSeq NM_001013366.1) ENSMUST00000081214.1 ENSMUST00000081214.10 ENSMUST00000081214.11 ENSMUST00000081214.2 ENSMUST00000081214.3 ENSMUST00000081214.4 ENSMUST00000081214.5 ENSMUST00000081214.6 ENSMUST00000081214.7 ENSMUST00000081214.8 ENSMUST00000081214.9 NM_001013366 Q7TMQ7 Q80XN1 WDR91_MOUSE Wdr91 uc009bhz.1 uc009bhz.2 uc009bhz.3 Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3- phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (By similarity). May play a role in meiosis (PubMed:27346680). Interacts with WDR81; involved in early to late endosome cargo transport. Interacts with BECN1; negatively regulates the PI3 kinase/PI3K activity associated with endosomal membranes. Early endosome membrane ; Peripheral membrane protein Late endosome membrane Belongs to the WD repeat WDR91 family. endosome cytosol membrane extrinsic component of endosome membrane early endosome membrane late endosome membrane phosphatidylinositol 3-kinase regulator activity regulation of phosphatidylinositol 3-kinase activity early endosome to late endosome transport regulation of cellular protein catabolic process uc009bhz.1 uc009bhz.2 uc009bhz.3 
ENSMUST00000081224.14 Fmnl3 ENSMUST00000081224.14 formin-like 3, transcript variant 3 (from RefSeq NM_001310623.1) ENSMUST00000081224.1 ENSMUST00000081224.10 ENSMUST00000081224.11 ENSMUST00000081224.12 ENSMUST00000081224.13 ENSMUST00000081224.2 ENSMUST00000081224.3 ENSMUST00000081224.4 ENSMUST00000081224.5 ENSMUST00000081224.6 ENSMUST00000081224.7 ENSMUST00000081224.8 ENSMUST00000081224.9 FMNL3_MOUSE Frl2 Kiaa2014 NM_001310623 Q3TCF9 Q3U2E4 Q6ZPF4 uc007xpl.1 uc007xpl.2 uc007xpl.3 uc007xpl.4 Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis. In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. Interacts with SRGAP2 (via SH3 domain). Q6ZPF4; O75044: SRGAP2; Xeno; NbExp=3; IntAct=EBI-774731, EBI-1051034; Q6ZPF4-1; P68135: ACTA1; Xeno; NbExp=3; IntAct=EBI-16027300, EBI-367540; Cytoplasm Cell membrane ; Lipid-anchor Note=Enriched in lamellipodia. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZPF4-1; Sequence=Displayed; Name=2; IsoId=Q6ZPF4-2; Sequence=VSP_025894, VSP_025895; The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity). Belongs to the formin homology family. Sequence=BAC98283.1; Type=Erroneous initiation; Evidence=; angiogenesis actin binding protein binding cytoplasm Golgi apparatus cytosol plasma membrane cytoskeleton organization multicellular organism development regulation of cell shape membrane cellular component organization cell migration Rho GTPase binding actin cytoskeleton organization cortical actin cytoskeleton organization GTPase activating protein binding intracellular membrane-bounded organelle uc007xpl.1 uc007xpl.2 uc007xpl.3 uc007xpl.4 
ENSMUST00000081232.9 Plcg2 ENSMUST00000081232.9 phospholipase C, gamma 2 (from RefSeq NM_172285.2) ENSMUST00000081232.1 ENSMUST00000081232.2 ENSMUST00000081232.3 ENSMUST00000081232.4 ENSMUST00000081232.5 ENSMUST00000081232.6 ENSMUST00000081232.7 ENSMUST00000081232.8 NM_172285 PLCG2_MOUSE Plcg2 Q3UBA8 Q3UQT0 Q8CIH5 Q8VE69 uc009npc.1 uc009npc.2 uc009npc.3 uc009npc.4 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33180; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Part of a complex composed of EEIG1, TNFRSF11A/RANK, PLCG2, GAB2, TEC and BTK; complex formation increases in the presence of TNFSF11/RANKL (PubMed:23478294). Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). Interacts constitutively with THEMIS2 (PubMed:27992403). Q8CIH5; P14753: Epor; NbExp=2; IntAct=EBI-617954, EBI-617901; Q8CIH5; O70433: Fhl2; NbExp=3; IntAct=EBI-617954, EBI-299379; Q8CIH5; Q8BTM8: Flna; NbExp=3; IntAct=EBI-617954, EBI-641991; Q8CIH5; P11276: Fn1; NbExp=6; IntAct=EBI-617954, EBI-641955; Q8CIH5; Q9ES52: Inpp5d; NbExp=3; IntAct=EBI-617954, EBI-300210; Q8CIH5; P25911: Lyn; NbExp=2; IntAct=EBI-617954, EBI-643537; Q8CIH5; Q9WU78: Pdcd6ip; NbExp=7; IntAct=EBI-617954, EBI-641897; Q8CIH5; Q62158: Trim27; NbExp=4; IntAct=EBI-617954, EBI-642025; Q8CIH5; Q64321: Zbtb7b; NbExp=3; IntAct=EBI-617954, EBI-642868; Membrane raft Phosphorylated on tyrosine residues by BTK and SYK; upon ligand- induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity (By similarity). Phosphorylated on tyrosine residues by CSF1R. phosphotyrosine binding positive regulation of receptor internalization follicular B cell differentiation phosphatidylinositol phospholipase C activity phospholipase C activity protein binding cytosol plasma membrane lipid metabolic process phosphatidylinositol biosynthetic process signal transduction positive regulation of cytosolic calcium ion concentration phosphoric diester hydrolase activity phospholipid catabolic process regulation of gene expression positive regulation of epithelial cell migration membrane lipid catabolic process hydrolase activity B cell differentiation response to magnesium ion activation of store-operated calcium channel activity positive regulation of type I interferon production response to lipopolysaccharide inositol trisphosphate biosynthetic process response to ATP intracellular signal transduction negative regulation of programmed cell death phosphatidylinositol-mediated signaling T cell receptor signaling pathway B cell receptor signaling pathway release of sequestered calcium ion into cytosol uc009npc.1 uc009npc.2 uc009npc.3 uc009npc.4 
ENSMUST00000081265.12 Ebf1 ENSMUST00000081265.12 early B cell factor 1, transcript variant 2 (from RefSeq NM_007897.3) ENSMUST00000081265.1 ENSMUST00000081265.10 ENSMUST00000081265.11 ENSMUST00000081265.2 ENSMUST00000081265.3 ENSMUST00000081265.4 ENSMUST00000081265.5 ENSMUST00000081265.6 ENSMUST00000081265.7 ENSMUST00000081265.8 ENSMUST00000081265.9 Ebf1 NM_007897 Q5SWK5 Q5SWK5_MOUSE uc007ink.1 uc007ink.2 uc007ink.3 uc007ink.4 Nucleus Belongs to the COE family. DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development metal ion binding protein dimerization activity uc007ink.1 uc007ink.2 uc007ink.3 uc007ink.4 
ENSMUST00000081271.7 Spink12 ENSMUST00000081271.7 serine peptidase inhibitor, Kazal type 12 (from RefSeq NM_030061.4) ENSMUST00000081271.1 ENSMUST00000081271.2 ENSMUST00000081271.3 ENSMUST00000081271.4 ENSMUST00000081271.5 ENSMUST00000081271.6 ISK12_MOUSE NM_030061 Q9D256 uc008eus.1 uc008eus.2 uc008eus.3 Inhibits trypsin. Secreted Expressed in epydiymis, in the caput. Sequence=AAI45915.1; Type=Erroneous initiation; Evidence=; Sequence=AAI45917.1; Type=Erroneous initiation; Evidence=; Sequence=ABD93327.1; Type=Erroneous initiation; Evidence=; Sequence=BAB32081.2; Type=Erroneous initiation; Evidence=; Sequence=BAE23072.1; Type=Erroneous initiation; Evidence=; serine-type endopeptidase inhibitor activity cellular_component extracellular region negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity negative regulation of proteolysis uc008eus.1 uc008eus.2 uc008eus.3 
ENSMUST00000081277.9 Serpinb12 ENSMUST00000081277.9 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12, transcript variant 1 (from RefSeq NM_027971.4) ENSMUST00000081277.1 ENSMUST00000081277.2 ENSMUST00000081277.3 ENSMUST00000081277.4 ENSMUST00000081277.5 ENSMUST00000081277.6 ENSMUST00000081277.7 ENSMUST00000081277.8 NM_027971 Q6UKZ3 Q9D7P9 SPB12_MOUSE uc007chc.1 uc007chc.2 uc007chc.3 Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator. May play a role in cell differentiation. Interacts with SLFN12; as part of a pathway regulating cell differentiation. Cytoplasm Belongs to the serpin family. Ov-serpin subfamily. hematopoietic progenitor cell differentiation serine-type endopeptidase inhibitor activity extracellular space cytoplasm negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc007chc.1 uc007chc.2 uc007chc.3 
ENSMUST00000081291.13 Gm57852 ENSMUST00000081291.13 predicted gene, 57852, transcript variant 1 (from RefSeq NM_019396.4) Chrp Cyhr1 ENSMUST00000081291.1 ENSMUST00000081291.10 ENSMUST00000081291.11 ENSMUST00000081291.12 ENSMUST00000081291.2 ENSMUST00000081291.3 ENSMUST00000081291.4 ENSMUST00000081291.5 ENSMUST00000081291.6 ENSMUST00000081291.7 ENSMUST00000081291.8 ENSMUST00000081291.9 H3BIV6 Kiaa0496 NM_019396 P0DW87 Q6P6J7 Q6ZQA2 Q9D134 Q9QXA1 ZTRF1_MOUSE Zftraf1 uc007wlf.1 uc007wlf.2 uc007wlf.3 uc007wlf.4 Interacts with LGALS3. Cytoplasm Cytoplasm, perinuclear region Note=Shows a prominent perinuclear and cytoplasmic localization. Event=Alternative splicing; Named isoforms=4; Name=5; IsoId=P0DW87-1, Q9QXA1-5; Sequence=Displayed; Name=1; IsoId=P0DW87-2, Q9QXA1-1; Sequence=VSP_061642; Name=6; IsoId=P0DW87-3, Q9QXA1-6; Sequence=VSP_061641, VSP_061643; Name=7; IsoId=P0DW87-4, Q9QXA1-7; Sequence=VSP_061643; Expressed in heart, brain, liver, testis and kidney. Belongs to the ZFTRAF1 family. Sequence=AAH62184.1; Type=Frameshift; Evidence=; Sequence=AAH82772.1; Type=Frameshift; Evidence=; Sequence=BAC97966.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC97966.1; Type=Frameshift; Evidence=; uc007wlf.1 uc007wlf.2 uc007wlf.3 uc007wlf.4 
ENSMUST00000081314.11 Blm ENSMUST00000081314.11 Bloom syndrome, RecQ like helicase, transcript variant 2 (from RefSeq NM_001042527.3) BLM_MOUSE ENSMUST00000081314.1 ENSMUST00000081314.10 ENSMUST00000081314.2 ENSMUST00000081314.3 ENSMUST00000081314.4 ENSMUST00000081314.5 ENSMUST00000081314.6 ENSMUST00000081314.7 ENSMUST00000081314.8 ENSMUST00000081314.9 NM_001042527 O88198 O88700 uc009iax.1 uc009iax.2 uc009iax.3 ATP-dependent DNA helicase that unwinds single- and double- stranded DNA in a 3'-5' direction (PubMed:9840919). Participates in DNA replication and repair (By similarity). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:9840919). Negatively regulates sister chromatid exchange (SCE) (PubMed:9840919, PubMed:27010503). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity). Recruited by the KHDC3-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Monomer. Homodimer (via N-terminus). Homotetramer (via N- terminus); dimer of dimers. Homohexamer (via N-terminus). Self- association negatively regulates DNA unwinding amplitude and rate. Oligomer complexes dissociate into monomer in presence of ATP. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with RMI complex. Interacts directly with RMI1 (via N-terminal region) component of RMI complex. Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts with the KHDC3/FILIA-OOEP/FLOPED scaffold complex and TRIM25 at DNA replication forks (PubMed:29125140). Interacts with ubiquitinated FANCD2 (By similarity). Interacts with SUPV3L1 (By similarity). Interacts with TOP3A (via N-terminal region). Interacts with SPIDR (via C-terminal region); the interaction is direct and required to target BLM to sites of DNA damage. Nucleus Note=Localized to DNA replication forks, especially after DNA damage. Highly expressed in testis 12-14 days after birth (corresponding to the pachytene phase) and at much lower levels in brain, heart, liver, lung, thymus, kidney and spleen (PubMed:9840919, PubMed:27010503). Expressed in bone marrow (PubMed:27010503). The N-terminal region mediates dimerization and homooligomerization. Both the helicase ATP-binding domain and the helicase C-terminal domain form intramolecular interactions with the HRDC domain in a ATP-dependent manner. The HRDC domain is required for single-stranded DNA (ssDNA) and DNA Holliday junction binding. Poly-ubiquitinated by TRIM25 at Lys-264. Deubiquitinated by USP37; leading to stabilization in order to sustain the DNA damage response (By similarity). Phosphorylated in response to DNA damage. Phosphorylation requires the FANCA-FANCC-FANCE-FANCF-FANCG protein complex, as well as the presence of RMI1 (By similarity). Belongs to the helicase family. RecQ subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity nucleotide binding nuclear chromosome four-way junction DNA binding Y-form DNA binding bubble DNA binding telomere maintenance double-strand break repair via homologous recombination DNA double-strand break processing DNA strand renaturation chromosome, telomeric region lateral element male germ cell nucleus p53 binding nucleic acid binding DNA binding DNA helicase activity single-stranded DNA binding catalytic activity helicase activity protein binding ATP binding nucleus nucleoplasm replication fork chromosome nucleolus cytoplasm cytosol DNA replication DNA unwinding involved in DNA replication DNA repair DNA recombination cellular response to DNA damage stimulus mitotic G2 DNA damage checkpoint DNA-dependent ATPase activity zinc ion binding four-way junction helicase activity response to X-ray nuclear matrix PML body hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ATPase activity replication fork processing DNA duplex unwinding cellular response to drug annealing helicase activity protein homodimerization activity 3'-5' DNA helicase activity cellular metabolic process G-quadruplex DNA unwinding pronucleus positive regulation of transcription, DNA-templated negative regulation of DNA recombination negative regulation of mitotic recombination alpha-beta T cell differentiation positive regulation of alpha-beta T cell proliferation metal ion binding regulation of binding protein oligomerization protein homooligomerization chromosome organization negative regulation of cell division G-quadruplex DNA binding forked DNA-dependent helicase activity telomeric D-loop disassembly telomeric D-loop binding negative regulation of thymocyte apoptotic process cellular response to ionizing radiation cellular response to hydroxyurea cellular response to camptothecin regulation of DNA-dependent DNA replication positive regulation of double-strand break repair via homologous recombination 8-hydroxy-2'-deoxyguanosine DNA binding replication-born double-strand break repair via sister chromatid exchange uc009iax.1 uc009iax.2 uc009iax.3 
ENSMUST00000081318.13 Sfi1 ENSMUST00000081318.13 Sfi1 homolog, spindle assembly associated (yeast), transcript variant 1 (from RefSeq NM_030207.3) ENSMUST00000081318.1 ENSMUST00000081318.10 ENSMUST00000081318.11 ENSMUST00000081318.12 ENSMUST00000081318.2 ENSMUST00000081318.3 ENSMUST00000081318.4 ENSMUST00000081318.5 ENSMUST00000081318.6 ENSMUST00000081318.7 ENSMUST00000081318.8 ENSMUST00000081318.9 Kiaa0542 NM_030207 Q3KQN2 Q3UZY0 Q5NC00 Q6ZQ99 Q80ZJ4 Q80ZY0 Q8R0V8 Q9CTY8 SFI1_MOUSE uc007hrt.1 uc007hrt.2 uc007hrt.3 Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. Interacts with CETN2 (via C-terminus). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localized close to the centriole. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q3UZY0-1; Sequence=Displayed; Name=2; IsoId=Q3UZY0-2; Sequence=VSP_033714; Name=3; IsoId=Q3UZY0-3; Sequence=VSP_033711, VSP_033714, VSP_033715; Name=4; IsoId=Q3UZY0-4; Sequence=VSP_033709, VSP_033710; Name=5; IsoId=Q3UZY0-5; Sequence=VSP_033712, VSP_033713, VSP_033716; CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for interaction with CETN2. Belongs to the SFI1 family. Sequence=AAH48950.1; Type=Erroneous initiation; Evidence=; cytoplasm centrosome centriole cytoskeleton negative regulation of phosphatase activity phosphatase binding uc007hrt.1 uc007hrt.2 uc007hrt.3 
ENSMUST00000081321.5 Poteg ENSMUST00000081321.5 POTE ankyrin domain family, member G, transcript variant 2 (from RefSeq NM_027618.1) A5H0M4 A5H0M4_MOUSE ENSMUST00000081321.1 ENSMUST00000081321.2 ENSMUST00000081321.3 ENSMUST00000081321.4 Gsarp1 NM_027618 Poteg uc009lix.1 uc009lix.2 molecular_function cellular_component biological_process uc009lix.1 uc009lix.2 
ENSMUST00000081333.11 Fxn ENSMUST00000081333.11 frataxin, transcript variant 1 (from RefSeq NM_008044.3) ENSMUST00000081333.1 ENSMUST00000081333.10 ENSMUST00000081333.2 ENSMUST00000081333.3 ENSMUST00000081333.4 ENSMUST00000081333.5 ENSMUST00000081333.6 ENSMUST00000081333.7 ENSMUST00000081333.8 ENSMUST00000081333.9 Fxn NM_008044 Q3TV21 Q3TV21_MOUSE uc008hao.1 uc008hao.2 uc008hao.3 Reaction=4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O; Xref=Rhea:RHEA:11148, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.16.3.1; Evidence=; Belongs to the frataxin family. ferroxidase activity mitochondrion cytosol cellular iron ion homeostasis ferrous iron binding ferric iron binding positive regulation of cell proliferation response to iron ion regulation of ferrochelatase activity iron-sulfur cluster assembly protein autoprocessing iron incorporation into metallo-sulfur cluster positive regulation of cell growth iron chaperone activity negative regulation of apoptotic process positive regulation of catalytic activity positive regulation of lyase activity 2 iron, 2 sulfur cluster binding oxidation-reduction process cellular response to hydrogen peroxide negative regulation of release of cytochrome c from mitochondria positive regulation of succinate dehydrogenase activity positive regulation of aconitate hydratase activity L-cysteine desulfurase complex uc008hao.1 uc008hao.2 uc008hao.3 
ENSMUST00000081334.5 Krtap19-1 ENSMUST00000081334.5 keratin associated protein 19-1 (from RefSeq NM_130876.3) ENSMUST00000081334.1 ENSMUST00000081334.2 ENSMUST00000081334.3 ENSMUST00000081334.4 G3XA43 G3XA43_MOUSE Krtap16-2 Krtap19-1 NM_130876 uc007zvh.1 uc007zvh.2 uc007zvh.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. uc007zvh.1 uc007zvh.2 uc007zvh.3 
ENSMUST00000081335.13 Tgif2 ENSMUST00000081335.13 TGFB-induced factor homeobox 2, transcript variant 1 (from RefSeq NM_173396.3) ENSMUST00000081335.1 ENSMUST00000081335.10 ENSMUST00000081335.11 ENSMUST00000081335.12 ENSMUST00000081335.2 ENSMUST00000081335.3 ENSMUST00000081335.4 ENSMUST00000081335.5 ENSMUST00000081335.6 ENSMUST00000081335.7 ENSMUST00000081335.8 ENSMUST00000081335.9 NM_173396 Q8C0Y1 TGIF2_MOUSE uc008nny.1 uc008nny.2 uc008nny.3 uc008nny.4 Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins (By similarity). Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1. Nucleus Note=Excluded from nucleoli. The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway. Belongs to the TALE/TGIF homeobox family. negative regulation of transcription from RNA polymerase II promoter DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of gastrulation nodal signaling pathway positive regulation of neuron differentiation retina development in camera-type eye uc008nny.1 uc008nny.2 uc008nny.3 uc008nny.4 
ENSMUST00000081339.13 Rrp1b ENSMUST00000081339.13 ribosomal RNA processing 1B, transcript variant 1 (from RefSeq NM_028244.2) B0V2W7 ENSMUST00000081339.1 ENSMUST00000081339.10 ENSMUST00000081339.11 ENSMUST00000081339.12 ENSMUST00000081339.2 ENSMUST00000081339.3 ENSMUST00000081339.4 ENSMUST00000081339.5 ENSMUST00000081339.6 ENSMUST00000081339.7 ENSMUST00000081339.8 ENSMUST00000081339.9 NM_028244 Q91YK2 RRP1B_MOUSE uc008bvt.1 uc008bvt.2 uc008bvt.3 uc008bvt.4 Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (By similarity). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (By similarity). Involved in regulation of mRNA splicing (PubMed:23604122). Inhibits SIPA1 GTPase activity (PubMed:18081427). Involved in regulating expression of extracellular matrix genes (PubMed:18081427). Associates with chromatin and may play a role in modulating chromatin structure (By similarity). Interacts with the transcriptional activator E2F1 (By similarity). Interacts with serine/threonine-protein phosphatase PP1 subunits PPP1CB and PPP1CC but not with PPP1CA (By similarity). Interacts with 60S ribosomal proteins RPL5 and RPL27, ribosomal processing protein RRP1/NNP1 and other nucleolar proteins including NOP2/NOL1 and FBL (By similarity). Also interacts with nucleolar protein NPM1/B23 (By similarity). Interacts with splicing factor SRSF1 and LUC7L3/CROP (By similarity). Interacts with GTPase activator SIPA1 (PubMed:18081427). Interacts with H1-10, NCL, PARP1, TRIM28 and YBX3 (By similarity). Nucleus, nucleolus Nucleus, nucleoplasm Chromosome Note=Predominantly located in the nucleolus with a small amount found in the nucleoplasm. Associates with the perichromatin region during metaphase and with cytoplasmic foci during telophase before reaccumulation in the nucleolus during G2. Associates with heterochromatin and euchromatin. Citrullinated by PADI4. Belongs to the RRP1 family. euchromatin heterochromatin granular component transcription coactivator activity protein binding nucleus nucleoplasm chromosome nucleolus rRNA processing mRNA processing apoptotic process RNA splicing negative regulation of phosphatase activity preribosome, large subunit precursor preribosome, small subunit precursor negative regulation of GTPase activity positive regulation of apoptotic process regulation of RNA splicing positive regulation by host of viral transcription positive regulation of transcription from RNA polymerase II promoter cellular response to virus uc008bvt.1 uc008bvt.2 uc008bvt.3 uc008bvt.4 
ENSMUST00000081342.7 H2ac24 ENSMUST00000081342.7 H2A clustered histone 24 (from RefSeq NM_178185.2) C0HKE9 ENSMUST00000081342.1 ENSMUST00000081342.2 ENSMUST00000081342.3 ENSMUST00000081342.4 ENSMUST00000081342.5 ENSMUST00000081342.6 H2A1P_MOUSE Hist1h2ap NM_178185 P10812 P22752 Q149U0 Q5SZZ2 uc007prt.1 uc007prt.2 uc007prt.3 uc007prt.4 uc007prt.5 uc007prt.6 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Sep 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007prt.1 uc007prt.2 uc007prt.3 uc007prt.4 uc007prt.5 uc007prt.6 
ENSMUST00000081374.4 Plac8l1 ENSMUST00000081374.4 PLAC8-like 1 (from RefSeq NM_027072.1) ENSMUST00000081374.1 ENSMUST00000081374.2 ENSMUST00000081374.3 NM_027072 PL8L1_MOUSE Q08EJ0 Q9DAB1 uc008etm.1 uc008etm.2 uc008etm.3 uc008etm.4 Belongs to the cornifelin family. molecular_function cellular_component biological_process uc008etm.1 uc008etm.2 uc008etm.3 uc008etm.4 
ENSMUST00000081379.7 Tcl1b2 ENSMUST00000081379.7 T cell leukemia/lymphoma 1B, 2, transcript variant 1 (from RefSeq NM_013775.2) ENSMUST00000081379.1 ENSMUST00000081379.2 ENSMUST00000081379.3 ENSMUST00000081379.4 ENSMUST00000081379.5 ENSMUST00000081379.6 NM_013775 Q4FZI4 Q4FZI4_MOUSE Tcl1b2 uc007oxv.1 uc007oxv.2 Belongs to the TCL1 family. protein serine/threonine kinase activator activity positive regulation of protein serine/threonine kinase activity uc007oxv.1 uc007oxv.2 
ENSMUST00000081380.10 Slco1a5 ENSMUST00000081380.10 solute carrier organic anion transporter family, member 1a5, transcript variant 2 (from RefSeq NM_130861.3) A0A0G2JDD1 A0A0G2JDD1_MOUSE ENSMUST00000081380.1 ENSMUST00000081380.2 ENSMUST00000081380.3 ENSMUST00000081380.4 ENSMUST00000081380.5 ENSMUST00000081380.6 ENSMUST00000081380.7 ENSMUST00000081380.8 ENSMUST00000081380.9 NM_130861 Slco1a5 uc029wck.1 uc029wck.2 uc029wck.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the organo anion transporter (TC 2.A.60) family. Lacks conserved residue(s) required for the propagation of feature annotation. plasma membrane ion transport monocarboxylic acid transmembrane transporter activity organic anion transmembrane transporter activity bile acid transmembrane transporter activity thyroid hormone transmembrane transporter activity organic anion transport monocarboxylic acid transport bile acid and bile salt transport membrane integral component of membrane animal organ regeneration brush border membrane intestinal absorption transmembrane transport thyroid hormone transport uc029wck.1 uc029wck.2 uc029wck.3 
ENSMUST00000081381.6 Mbtps1 ENSMUST00000081381.6 membrane-bound transcription factor peptidase, site 1, transcript variant 2 (from RefSeq NM_001167910.1) ENSMUST00000081381.1 ENSMUST00000081381.2 ENSMUST00000081381.3 ENSMUST00000081381.4 ENSMUST00000081381.5 MBTP1_MOUSE NM_001167910 Q6PG67 Q9WTZ2 S1p Ski1 uc009npt.1 uc009npt.2 uc009npt.3 uc009npt.4 uc009npt.5 Serine protease that cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4: known substrates include SREBF1/SREBP1, SREBF2/SREBP2, BDNF, GNPTAB, ATF6, ATF6B and FAM20C. Cleaves substrates after Arg-Ser-Val-Leu (SREBP2), Arg-His-Leu- Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg- Arg-Leu-Leu. Catalyzes the first step regulated intramembrane proteolysis activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Also mediates the first step of the regulated intramembrane proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. Cleaves the propeptide from FAM20C which is required for FAM20C secretion from the Golgi apparatus membrane and for enhancement of FAM20C kinase activity, promoting osteoblast differentiation and biomineralization (PubMed:34349020). Involved in the regulation of M6P-dependent Golgi- to-lysosome trafficking of lysosomal enzymes. It is required for the activation of CREB3L2/BBF2H7, a transcriptional activator of MIA3/TANGO and other genes controlling mega vesicle formation. Therefore, it plays a key role in the regulation of mega vesicle-mediated collagen trafficking. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the first step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression (By similarity). Reaction=Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3.; EC=3.4.21.112; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Inhibited by divalent copper and zinc ions, but not by nickel or cobalt. Inhibited by its prosegment, but not smaller fragments. Inhibited by 4-(2-aminoethyl)benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor. Interacts with LYSET; this interaction bridges GNPTAB to MBTPS1. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Golgi apparatus membrane ; Single-pass type I membrane protein Note=May sort to other organelles, including lysosomal and/or endosomal compartments. The 148 kDa zymogen is processed progressively into two membrane- bound 120 and 106 kDa forms in the endoplasmic reticulum, and late into a secreted 98 kDa form. The propeptide is autocatalytically removed through an intramolecular cleavage after Leu-186. Further cleavage generates 14, 10, and 8 kDa intermediates. Belongs to the peptidase S8 family. Golgi membrane endopeptidase activity serine-type endopeptidase activity endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane Golgi apparatus Golgi stack proteolysis protein import into nucleus lipid metabolic process lysosome organization steroid metabolic process cholesterol metabolic process peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc009npt.1 uc009npt.2 uc009npt.3 uc009npt.4 uc009npt.5 
ENSMUST00000081387.11 Birc5 ENSMUST00000081387.11 baculoviral IAP repeat-containing 5, transcript variant 1 (from RefSeq NM_009689.2) Birc5 ENSMUST00000081387.1 ENSMUST00000081387.10 ENSMUST00000081387.2 ENSMUST00000081387.3 ENSMUST00000081387.4 ENSMUST00000081387.5 ENSMUST00000081387.6 ENSMUST00000081387.7 ENSMUST00000081387.8 ENSMUST00000081387.9 NM_009689 Q549P2 Q549P2_MOUSE Tiap uc007mod.1 uc007mod.2 uc007mod.3 This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]. Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Midbody Nucleus Belongs to the IAP family. metal ion binding uc007mod.1 uc007mod.2 uc007mod.3 
ENSMUST00000081393.10 Nphp4 ENSMUST00000081393.10 nephronophthisis 4 (juvenile) homolog (human), transcript variant 1 (from RefSeq NM_153424.2) B1AS30 ENSMUST00000081393.1 ENSMUST00000081393.2 ENSMUST00000081393.3 ENSMUST00000081393.4 ENSMUST00000081393.5 ENSMUST00000081393.6 ENSMUST00000081393.7 ENSMUST00000081393.8 ENSMUST00000081393.9 NM_153424 NPHP4_MOUSE P59240 uc008wap.1 uc008wap.2 uc008wap.3 Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (By similarity). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (By similarity). Interacts with NPHP1 and RPGRIP1L/NPHP8; NPHP1, NPHP4 and RPGRIP1L are proposed to form a functional NPHP1-4-8 module localized to cell-cell contacts and the ciliary transition zone; NPHP4 mediates the interaction between NPHP1 and RPGRIP1L. Interacts with IQCB1/NPHP5; the interaction likely requires additional interactors (PubMed:21565611). Interacts with RPGRIP1, CEP164, JADE1, PALS1, INADL, PARD6A, INVS, DVL2. Interacts with INTU; INTU mediates the interaction between NPHP4 and DAAM1. Interacts with JADE1 (By similarity). Interacts with SPATA7 (PubMed:29899041). P59240; Q9QY53: Nphp1; NbExp=8; IntAct=EBI-4281265, EBI-77230; P59240; Q8CG73: Rpgrip1l; NbExp=4; IntAct=EBI-4281265, EBI-4281130; Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cell junction, tight junction Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium (PubMed:29899041). In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions (PubMed:21565611). Localizes to the ciliary transition zone (PubMed:21565611). Expressed in the retina (at protein level). Belongs to the NPHP4 family. protein binding cytoplasm centrosome microtubule organizing center cytoskeleton cell-cell junction bicellular tight junction cilium cell junction flagellated sperm motility photoreceptor connecting cilium photoreceptor cell outer segment organization ciliary transition zone ciliary basal body cell projection photoreceptor cell maintenance retina development in camera-type eye negative regulation of canonical Wnt signaling pathway ribbon synapse ciliary base non-motile cilium positive regulation of bicellular tight junction assembly protein localization to ciliary transition zone uc008wap.1 uc008wap.2 uc008wap.3 
ENSMUST00000081399.4 Klk1b9 ENSMUST00000081399.4 kallikrein 1-related peptidase b9 (from RefSeq NM_010116.1) ENSMUST00000081399.1 ENSMUST00000081399.2 ENSMUST00000081399.3 Egfbp3 K1KB9_MOUSE Klk-9 Klk9 NM_010116 P15949 uc009god.1 uc009god.2 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M17962.1, BC024624.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Reaction=Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl- bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|- Xaa.; EC=3.4.21.35; Belongs to the peptidase S1 family. Kallikrein subfamily. regulation of systemic arterial blood pressure endopeptidase activity serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides secretory granule zymogen activation macromolecular complex uc009god.1 uc009god.2 
ENSMUST00000081435.5 H2-Q4 ENSMUST00000081435.5 histocompatibility 2, Q region locus 4 (from RefSeq NM_001143689.1) ENSMUST00000081435.1 ENSMUST00000081435.2 ENSMUST00000081435.3 ENSMUST00000081435.4 H2-Gs10 H2-Q1 H2-Q4 H2-gs10 NM_001143689 Q8HWB2 Q8HWB2_MOUSE uc008chm.1 uc008chm.2 uc008chm.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response external side of plasma membrane cell surface integral component of membrane beta-2-microglobulin binding peptide binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex TAP binding protein heterodimerization activity endoplasmic reticulum exit site uc008chm.1 uc008chm.2 uc008chm.3 
ENSMUST00000081438.10 Adrb3 ENSMUST00000081438.10 adrenergic receptor, beta 3 (from RefSeq NM_013462.3) Adrb3 ENSMUST00000081438.1 ENSMUST00000081438.2 ENSMUST00000081438.3 ENSMUST00000081438.4 ENSMUST00000081438.5 ENSMUST00000081438.6 ENSMUST00000081438.7 ENSMUST00000081438.8 ENSMUST00000081438.9 NM_013462 Q3UP63 Q3UP63_MOUSE uc009lie.1 uc009lie.2 Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis. Interacts with ARRDC3. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity adrenergic receptor activity beta-adrenergic receptor activity nucleus plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway aging response to cold membrane integral component of membrane eating behavior response to antibiotic epinephrine binding norepinephrine binding adrenergic receptor signaling pathway uc009lie.1 uc009lie.2 
ENSMUST00000081440.14 Scnn1a ENSMUST00000081440.14 sodium channel, nonvoltage-gated 1 alpha, transcript variant 1 (from RefSeq NM_011324.3) ENSMUST00000081440.1 ENSMUST00000081440.10 ENSMUST00000081440.11 ENSMUST00000081440.12 ENSMUST00000081440.13 ENSMUST00000081440.2 ENSMUST00000081440.3 ENSMUST00000081440.4 ENSMUST00000081440.5 ENSMUST00000081440.6 ENSMUST00000081440.7 ENSMUST00000081440.8 ENSMUST00000081440.9 NM_011324 Q61180 Q9WU37 SCNNA_MOUSE uc009duk.1 uc009duk.2 uc009duk.3 uc009duk.4 Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Activated by WNK1, WNK2, WNK3 and WNK4. Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties (Probable). Interacts with NEDD4 (via WW domains) (PubMed:11244092, PubMed:15123669). Interacts with NEDD4L (via WW domains) (PubMed:11244092, PubMed:12424229, PubMed:15123669). Interacts with WWP1 (via WW domains). Interacts with WWP2 (via WW domains). Interacts with the full-length immature form of PCSK9 (pro-PCSK9). Apical cell membrane ; Multi-pass membrane protein Cell projection, cilium Cytoplasmic granule Cytoplasm Cytoplasmic vesicle, secretory vesicle, acrosome Cell projection, cilium, flagellum Note=In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non- ciliated epithelial cells, restricted to apical surfaces. In epidermis, located nearly uniformly in the cytoplasm in a granular distribution. In sebaceous glands, observed only in the cytoplasmic space in between the lipid vesicles. In eccrine sweat glands, mainly located at the apical surface of the cells facing the lumen. In skin, in arrector pili muscle cells and in adipocytes, located in the cytoplasm and colocalized with actin fibers. In spermatogonia, spermatocytes and round spermatids, located in the cytoplasm. Prior to spermiation, location shifts from the cytoplasm to the spermatid tail. In spermatozoa, localizes at the acrosome and the central region of the sperm flagellum. Expressed in kidney (at protein level) (PubMed:22207244). Expressed in lung (at protein level) (PubMed:22207244, PubMed:30659401). Expressed in the epididymis (at protein level) (PubMed:30659401). In the caput and corpus regions of the epididymis, expressed uniformly on the luminal and basal surfaces of the ducts and in the sperm in the duct lumen (PubMed:30659401). Also expressed in distal colon and, at low levels, in liver (PubMed:10409305). Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation. ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation. N-glycosylated. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily. acrosomal vesicle actin binding sodium channel activity cytoplasm cytosol plasma membrane integral component of plasma membrane cilium ion transport sodium ion transport external side of plasma membrane ligand-gated sodium channel activity membrane integral component of membrane apical plasma membrane cortical actin cytoskeleton cytoplasmic vesicle motile cilium sodium channel complex sodium ion transmembrane transport cell projection WW domain binding regulation of body fluid levels multicellular organismal water homeostasis response to stimulus sensory perception of taste sodium ion homeostasis ciliary membrane extracellular exosome sperm principal piece uc009duk.1 uc009duk.2 uc009duk.3 uc009duk.4 
ENSMUST00000081471.3 Zfp1000 ENSMUST00000081471.3 Zfp1000 (from geneSymbol) AB010343 ENSMUST00000081471.1 ENSMUST00000081471.2 F7AGA8 Gm10139 Gm17404 O88245 O88245_MOUSE Zfp1000 mszf85 uc288nzd.1 uc288nzd.2 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc288nzd.1 uc288nzd.2 
ENSMUST00000081491.13 Oas2 ENSMUST00000081491.13 2'-5' oligoadenylate synthetase 2, transcript variant 1 (from RefSeq NM_001347448.1) E9Q9A9 ENSMUST00000081491.1 ENSMUST00000081491.10 ENSMUST00000081491.11 ENSMUST00000081491.12 ENSMUST00000081491.2 ENSMUST00000081491.3 ENSMUST00000081491.4 ENSMUST00000081491.5 ENSMUST00000081491.6 ENSMUST00000081491.7 ENSMUST00000081491.8 ENSMUST00000081491.9 NM_001347448 OAS2_MOUSE Oas2 Q8K4E5 Q8VI92 oasl11 uc008zhw.1 uc008zhw.2 uc008zhw.3 uc008zhw.4 Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:12396720, PubMed:29117179). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:29117179). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:21142819). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (PubMed:29117179). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (PubMed:29117179). Reaction=3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')- adenosine + 2 diphosphate; Xref=Rhea:RHEA:34407, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:67143; EC=2.7.7.84; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Produced as a latent enzyme which is activated by double stranded RNA (dsRNA) generated during the course of viral infection (PubMed:29117179). The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is tolerated (By similarity). ssRNA or dsDNA do not act as activators (By similarity). Strongly inhibited by copper, iron and zinc ions (By similarity). Partially inhibited by cobalt and nickel ions (By similarity). Kinetic parameters: KM=1.9 mM for ATP ; Note=kcat is 6.4 sec(-1) for ATP. ; Homodimer. Cytoplasm Cytoplasm, perinuclear region Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q9A9-1; Sequence=Displayed; Name=2; IsoId=E9Q9A9-2; Sequence=VSP_044068; Expressed in the uterus (PubMed:12396720). Expressed in mammary glands: expressed at low level before the establishment of lactation, then expression strongly increases, and subsequently decreases during early involution (PubMed:29117179). Myristoylation is not essential for its activity. Glycosylated. Glycosylation is essential for its activity. Belongs to the 2-5A synthase family. nucleotide binding 2'-5'-oligoadenylate synthetase activity immune system process RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm cytoplasm cytosol RNA catabolic process immune response response to virus response to bacterium transferase activity nucleotidyltransferase activity intracellular membrane-bounded organelle negative regulation of viral genome replication innate immune response metal ion binding perinuclear region of cytoplasm defense response to virus type I interferon signaling pathway regulation of ribonuclease activity regulation of lactation uc008zhw.1 uc008zhw.2 uc008zhw.3 uc008zhw.4 
ENSMUST00000081496.6 Ltbp3 ENSMUST00000081496.6 latent transforming growth factor beta binding protein 3 (from RefSeq NM_008520.3) ENSMUST00000081496.1 ENSMUST00000081496.2 ENSMUST00000081496.3 ENSMUST00000081496.4 ENSMUST00000081496.5 F8VQ06 LTBP3_MOUSE NM_008520 Q61810 Q8BNQ6 uc008gff.1 uc008gff.2 Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Forms part of the large latent transforming growth factor beta (TGFB1) precursor complex; removal is essential for activation of complex. Interacts with EFEMP2 (By similarity). Secreted Secreted, extracellular space, extracellular matrix Note=Secretion occurs after coexpression with TGFB1 and requires complexing with 'Cys-33' of the TGFB1 propeptide. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61810-1; Sequence=Displayed; Name=2; IsoId=Q61810-2; Sequence=VSP_009242, VSP_009243; At 8.5-9.0 dpc highly expressed in liver. Significant expression was also seen in the developing central nervous, somites and cardiovascular tissue. At 13.5-16.5 dpc expression was seen in osteoblasts, respiratory epithelial cells, and nephrons and dermal connective tissue. Contains hydroxylated asparagine residues. Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix. Belongs to the LTBP family. Sequence=AAB53015.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAB53015.1; Type=Frameshift; Evidence=; skeletal system development calcium ion binding extracellular region transforming growth factor beta receptor signaling pathway growth factor binding negative regulation of bone mineralization extracellular matrix negative regulation of chondrocyte differentiation transforming growth factor beta activation positive regulation of bone resorption bone remodeling transforming growth factor beta binding bone morphogenesis lung saccule development positive regulation of mesenchymal stem cell proliferation positive regulation of mesenchymal stem cell differentiation uc008gff.1 uc008gff.2 
ENSMUST00000081497.13 Pop5 ENSMUST00000081497.13 processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae), transcript variant 1 (from RefSeq NM_026398.5) ENSMUST00000081497.1 ENSMUST00000081497.10 ENSMUST00000081497.11 ENSMUST00000081497.12 ENSMUST00000081497.2 ENSMUST00000081497.3 ENSMUST00000081497.4 ENSMUST00000081497.5 ENSMUST00000081497.6 ENSMUST00000081497.7 ENSMUST00000081497.8 ENSMUST00000081497.9 NM_026398 POP5_MOUSE Q9CSC3 Q9CSL4 Q9DB28 uc008zdi.1 uc008zdi.2 uc008zdi.3 uc008zdi.4 Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Nucleus, nucleolus Belongs to the eukaryotic/archaeal RNase P protein component 2 family. Sequence=BAB28294.1; Type=Frameshift; Evidence=; ribonuclease MRP activity ribonuclease MRP complex tRNA 5'-leader removal ribonuclease P activity ribonuclease activity nucleus nucleolar ribonuclease P complex nucleolus rRNA processing tRNA processing RNA metabolic process hydrolase activity multimeric ribonuclease P complex ribonuclease P RNA binding RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc008zdi.1 uc008zdi.2 uc008zdi.3 uc008zdi.4 
ENSMUST00000081503.13 Pbx4 ENSMUST00000081503.13 pre B cell leukemia homeobox 4, transcript variant 4 (from RefSeq NM_001357308.1) ENSMUST00000081503.1 ENSMUST00000081503.10 ENSMUST00000081503.11 ENSMUST00000081503.12 ENSMUST00000081503.2 ENSMUST00000081503.3 ENSMUST00000081503.4 ENSMUST00000081503.5 ENSMUST00000081503.6 ENSMUST00000081503.7 ENSMUST00000081503.8 ENSMUST00000081503.9 NM_001357308 PBX4_MOUSE Q8CFL2 Q99NE8 Q99NE9 uc009lxx.1 uc009lxx.2 uc009lxx.3 Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99NE9-1; Sequence=Displayed; Name=2; Synonyms=Truncated; IsoId=Q99NE9-2; Sequence=VSP_008617, VSP_008618; Almost exclusively expressed in testis. Expressed in spermatocytes in the pachytene stage of the first meiotic prophase. Belongs to the TALE/PBX homeobox family. XY body DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding positive regulation of transcription, DNA-templated uc009lxx.1 uc009lxx.2 uc009lxx.3 
ENSMUST00000081510.4 Mgmt ENSMUST00000081510.4 O-6-methylguanine-DNA methyltransferase, transcript variant 11 (from RefSeq NR_182026.1) ENSMUST00000081510.1 ENSMUST00000081510.2 ENSMUST00000081510.3 MGMT_MOUSE NR_182026 P26187 Q54A49 uc009keq.1 uc009keq.2 uc009keq.3 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Reaction=a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:24000, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:10132, Rhea:RHEA-COMP:11367, Rhea:RHEA-COMP:11368, ChEBI:CHEBI:29950, ChEBI:CHEBI:82612, ChEBI:CHEBI:85445, ChEBI:CHEBI:85448; EC=2.1.1.63; Evidence=; Reaction=a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:53428, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:10132, Rhea:RHEA-COMP:13555, Rhea:RHEA-COMP:13556, ChEBI:CHEBI:29950, ChEBI:CHEBI:82612, ChEBI:CHEBI:137386, ChEBI:CHEBI:137387; EC=2.1.1.63; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion. ; Nucleus This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. Belongs to the MGMT family. DNA binding catalytic activity methylated-DNA-[protein]-cysteine S-methyltransferase activity calcium ion binding nucleus nucleoplasm DNA repair DNA dealkylation involved in DNA repair cellular response to DNA damage stimulus methyltransferase activity response to toxic substance response to organic cyclic compound transferase activity methylation cellular response to oxidative stress response to drug negative regulation of apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process response to ethanol positive regulation of DNA repair metal ion binding response to folic acid negative regulation of cell death mammary gland epithelial cell differentiation cellular response to organic cyclic compound cellular response to ionizing radiation positive regulation of double-strand break repair uc009keq.1 uc009keq.2 uc009keq.3 
ENSMUST00000081527.3 Alyref2 ENSMUST00000081527.3 Aly/REF export factor 2 (from RefSeq NM_019484.4) Alyref2 ENSMUST00000081527.1 ENSMUST00000081527.2 G3X9I4 G3X9I4_MOUSE NM_019484 uc007dop.1 uc007dop.2 uc007dop.3 nucleic acid binding RNA binding uc007dop.1 uc007dop.2 uc007dop.3 
ENSMUST00000081541.9 Acnat2 ENSMUST00000081541.9 acyl-coenzyme A amino acid N-acyltransferase 2, transcript variant 1 (from RefSeq NM_145368.3) ACNT2_MOUSE Acnat2 B2D099 ENSMUST00000081541.1 ENSMUST00000081541.2 ENSMUST00000081541.3 ENSMUST00000081541.4 ENSMUST00000081541.5 ENSMUST00000081541.6 ENSMUST00000081541.7 ENSMUST00000081541.8 NM_145368 Q8BGG9 Q91XC7 uc008svq.1 uc008svq.2 uc008svq.3 Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine (By similarity). Peroxisome Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8BGG9-1; Sequence=Displayed; Name=2 ; IsoId=Q8BGG9-2; Sequence=VSP_052954; Belongs to the C/M/P thioester hydrolase family. Sequence=AAH10829.1; Type=Erroneous initiation; Evidence=; Sequence=CAM27903.3; Type=Erroneous initiation; Evidence=; peroxisome lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process N-acyltransferase activity transferase activity transferase activity, transferring acyl groups thiolester hydrolase activity acyl-CoA hydrolase activity uc008svq.1 uc008svq.2 uc008svq.3 
ENSMUST00000081542.6 Kcnd2 ENSMUST00000081542.6 potassium voltage-gated channel, Shal-related family, member 2 (from RefSeq NM_019697.4) ENSMUST00000081542.1 ENSMUST00000081542.2 ENSMUST00000081542.3 ENSMUST00000081542.4 ENSMUST00000081542.5 KCND2_MOUSE Kiaa1044 MNCb-7013 NM_019697 Q8BSK3 Q8CHB7 Q9JJ60 Q9Z0V2 uc009baq.1 uc009baq.2 uc009baq.3 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in rodent heart. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (PubMed:10818150, PubMed:17122039, PubMed:18045912, PubMed:18187474, PubMed:20371829, PubMed:22815518). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites (PubMed:10818150, PubMed:17122039, PubMed:22815518). Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (PubMed:22815518). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (PubMed:18045912). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member (PubMed:9734479, PubMed:10601491, PubMed:11909823, PubMed:23713033). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:9734479, PubMed:22311982). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel (PubMed:11909823). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes (PubMed:11909823). Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (By similarity). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (PubMed:22311982). Kinetic parameters: Note=Homotetrameric channels activate rapidly, i.e within a few msec. After that, they inactivate rapidly, i.e within about 50-100 msec. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system and the presence or absence of ancillary subunits. Homotetrameric channels have a unitary conductance of about 4 pS when expressed in a heterologous system. For the activation of homotetrameric channels expressed in xenopus oocytes, the voltage at half-maximal amplitude is about -10 mV. The time constant for inactivation is about 20 msec. For inactivation, the voltage at half-maximal amplitude is -62 mV. The time constant for recovery after inactivation is about 70 msec. ; Homotetramer or heterotetramer with KCND3 or KCND1 (PubMed:9734479, PubMed:11909823, PubMed:19713751, PubMed:20943905). Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (PubMed:11909823, PubMed:19713751, PubMed:20943905). In vivo, probably exists as heteromeric complex containing variable proportions of KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (PubMed:19713751). The tetrameric channel can associate with up to four regulatory subunits, such as KCNIP2 or KCNIP4 (By similarity). Interaction with four KCNIP4 chains does not reduce interaction with DPP10 (By similarity). Interacts with DLG1 (By similarity). Interacts with DLG4 (By similarity). Interacts with NCS1/FREQ (PubMed:11606724). Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2 (By similarity). Interacts with FLNA and FLNC (By similarity). Interacts with DPP6 and DPP10 (PubMed:19713751, PubMed:22311982). Identified in a complex with cAMP-dependent protein kinase (PKA), CAV3, AKAP6 and KCND3 in cardiac myocytes (By similarity). Q9Z0V2; Q99PW8: Kif17; NbExp=3; IntAct=EBI-959779, EBI-959754; Cell membrane ulti-pass membrane protein Cell projection, dendrite napse rikaryon stsynaptic cell membrane Cell projection, dendritic spine Cell junction Membrane, caveola Cell membrane, sarcolemma Note=In neurons, primarily detected on dendrites, dendritic spines and on the neuron cell body, but not on axons (PubMed:17122053, PubMed:22098631). Localized preferentially at the dendrites of pyramidal cells in the hippocampus CA1 layer. Detected at GABAergic synapses (PubMed:16009497). Detected at cell junctions that are distinct from synaptic cell contacts (By similarity). Detected in lipid rafts (By similarity). Detected primarily at the endoplasmic reticulum or Golgi when expressed by itself (By similarity). Interaction with KCNIP1, KCNIP2, KCNIP3 or KCNIP4 promotes expression at the cell membrane (PubMed:22311982). Interaction with DPP6 or DPP10 promotes expression at the cell membrane (By similarity). Internalized from the cell membrane by clathrin-dependent endocytosis in response to activation of AMPA-selective glutamate receptors and PKA-mediated phosphorylation at Ser-552. Redistributed from dendritic spines to the main dendritic shaft in response to activation of AMPA-selective glutamate receptors and activation of PKA (By similarity). Detected in hippocampus, thalamus, medial habenular nucleus, striatum, amygdala, brain cortex and cerebellum (PubMed:11040264, PubMed:17122039, PubMed:18187474, PubMed:20371829, PubMed:22612819). Detected in hippocampus CA1 and CA3 layer, in stratum oriens, stratum radiatum and stratum lacunosum-moleculare and in dentate gyrus (PubMed:16009497, PubMed:22098631). Detected in dorsal horn neurons; colocalizes with GRM5 (PubMed:18045912). C-terminally phosphorylated forms are detected in the stratum radiatum and in basilar dendrites in stratum oriens in hippocampus CA1 and on cell bodies in hippocampus CA3 layers, with lower levels in stratum lacunosum-moleculare (PubMed:11040264). In contrast, N-terminally phosphorylated forms are detected in stratum lacunosum moleculare in the hippocampus CA1 layer (PubMed:11040264). Both C-terminally and N- terminally phosphorylated forms are observed on cell bodies and neuronal processes in the amygdala (PubMed:11040264). C-terminally phosphorylated forms are detected in the dentate gyrus molecular layer, while N-terminally phosphorylated forms are detected in the hilus of the dentate gyrus (PubMed:11040264). Both N-terminally and C-terminally phosphorylated forms are detected in the somatosensory cortex (PubMed:11040264). C-terminally phosphorylated forms are detected in the cerebellum granular layers (PubMed:11040264). Detected in heart ventricle myocytes (at protein level) (PubMed:9734479, PubMed:11909823, PubMed:16293790, PubMed:23713033). Detected in brain and heart (PubMed:16293790). The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. The N-terminal cytoplasmic region can mediate N-type inactivation by physically blocking the channel (By similarity). This probably does not happen in vivo, where the N-terminal region mediates interaction with regulatory subunits, such as KCNIP1 and KCNIP2 (By similarity). The zinc binding sites in the N-terminal domain are important for tetramerization and assembly of a functional channel complex (By similarity). Most likely, the channel undergoes closed- state inactivation, where a subtle conformation change would render the protein less sensitive to activation. The C-terminal cytoplasmic region is important for normal expression at the cell membrane and modulates the voltage-dependence of channel activation and inactivation. It is required for interaction with KCNIP2, and probably other family members as well. Phosphorylation at Ser-438 in response to MAPK activation is increased in stimulated dendrites. Interaction with KCNIP2 and DPP6 propomtes phosphorylation by PKA at Ser-552. Phosphorylation at Ser-552 has no effect on interaction with KCNIP3, but is required for the regulation of channel activity by KCNIP3. Phosphorylation at Ser-552 leads to KCND2 internalization (By similarity). Phosphorylated by MAPK in response to signaling via the metabotropic glutamate receptor GRM5 (PubMed:18045912). Phosphorylation at Ser-616 is required for the down- regulation of neuronal A-type currents in response to signaling via GRM5 (PubMed:18045912). Mice are viable, fertile and appear to be in good health (PubMed:16293790, PubMed:22738428). The loss of KCND2 has only minor functional consequences, probably due to an increase of the activity of other potassium channels, even though there is no visible change of their expression levels (PubMed:20371829). Mutant mice show no sign of heart dysfunction, but the fast component of the rapidly inactivating and rapidly recovering potassium current I(to) is lost in their ventricular myocytes (PubMed:16293790). Instead, a slowly inactivating current is expressed that is not observed in wild-type (PubMed:16293790). Electrocardiograms of mutant hearts display no significant differences relative to wild-type regarding their QT, PR, QRS and RR intervals (PubMed:16293790). The neuronal A-type current is reduced by about 80% in brain cortex and hippocampus CA1 pyramidal neurons, by about 50% in suprachiasmatic nucleus neurons and by about 60% in dorsal horn neurons (PubMed:17122039, PubMed:18045912, PubMed:18187474, PubMed:20371829, PubMed:22815518). The dendritic A- type current is abolished in pyramidal neurons from the hippocampus CA1 layer (PubMed:17122039). Concomitantly, the back-propagation of action potential in dendrites is increased (PubMed:17122039). This may lower the treshold for neuronal long-term potentiation (LTP) (PubMed:17122039). Loss of KCND2 does not influence the levels of KCND3 or KCNA4, but leads to reduced KCNIP1, KCNIP2 and KCNIP3 protein levels (PubMed:17122039, PubMed:18187474, PubMed:22612819). Mutant mice show only minor differences in their behavior when compared to wild-type; they display hyperactivity to some, but not all, novel stimuli (PubMed:22738428). Mutant mice show subtle spatial learning deficits (PubMed:20857488). Mutant mice display shorter periods of locomotor activity that wild-type littermates, due to a corresponding change in the circadian rhythm of repetitive firing in suprachiasmatic nucleus neurons (PubMed:22815518). Mutant mice display loss of spontaneous nociceptive behavior that is caused by the activation of GRM5 (PubMed:18045912). The transient neuronal A-type potassium current called I(SA) is triggered at membrane potentials that are below the threshold for action potentials. It inactivates rapidly and recovers rapidly from inactivation. It regulates the firing of action potentials and plays a role in synaptic integration and plasticity. Potassium channels containing KCND2 account for about 80% of the neuronal A-type potassium current. In contrast, the potassium channel responsible for the cardiac I(to) current differs between species; it is mediated by KCND2 in rodents. In human and other non-rodents KCND3 may play an equivalent role. Is specifically and reversibly inhibited by the scorpion toxin Ts8 (AC P69940). Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily. Sequence=BAA97986.1; Type=Frameshift; Evidence=; Sequence=BAC41464.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; action potential ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity A-type (transient outward) potassium channel activity potassium channel activity protein binding plasma membrane integral component of plasma membrane caveola ion transport potassium ion transport voltage-gated potassium channel complex postsynaptic density membrane integral component of membrane neuronal action potential sensory perception of pain cell junction T-tubule dendrite intrinsic component of plasma membrane neuronal cell body membrane potassium channel complex regulation of ion transmembrane transport sarcolemma cell projection neuron projection neuronal cell body dendritic spine perikaryon plasma membrane raft synapse postsynaptic membrane locomotor rhythm metal ion binding protein heterodimerization activity protein homooligomerization protein heterooligomerization transmembrane transport regulation of postsynaptic membrane potential cellular response to hypoxia potassium ion transmembrane transport cardiac muscle cell action potential perinuclear endoplasmic reticulum glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of postsynaptic specialization membrane voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential uc009baq.1 uc009baq.2 uc009baq.3 
ENSMUST00000081551.14 Tcea1 ENSMUST00000081551.14 transcription elongation factor A (SII) 1, transcript variant 2 (from RefSeq NM_011541.4) ENSMUST00000081551.1 ENSMUST00000081551.10 ENSMUST00000081551.11 ENSMUST00000081551.12 ENSMUST00000081551.13 ENSMUST00000081551.2 ENSMUST00000081551.3 ENSMUST00000081551.4 ENSMUST00000081551.5 ENSMUST00000081551.6 ENSMUST00000081551.7 ENSMUST00000081551.8 ENSMUST00000081551.9 NM_011541 Q3UWX7 Q3UWX7_MOUSE Tcea1 uc007afi.1 uc007afi.2 uc007afi.3 uc007afi.4 Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. Nucleus Belongs to the TFS-II family. nucleic acid binding nucleus transcription, DNA-templated regulation of transcription, DNA-templated zinc ion binding metal ion binding uc007afi.1 uc007afi.2 uc007afi.3 uc007afi.4 
ENSMUST00000081553.6 Gm1330 ENSMUST00000081553.6 Gm1330 (from geneSymbol) ENSMUST00000081553.1 ENSMUST00000081553.2 ENSMUST00000081553.3 ENSMUST00000081553.4 ENSMUST00000081553.5 F6TZH1 F6TZH1_MOUSE Gm1330 uc290bej.1 uc290bej.2 molecular_function cellular_component biological_process uc290bej.1 uc290bej.2 
ENSMUST00000081567.11 Mtf2 ENSMUST00000081567.11 metal response element binding transcription factor 2, transcript variant 1 (from RefSeq NM_013827.3) ENSMUST00000081567.1 ENSMUST00000081567.10 ENSMUST00000081567.2 ENSMUST00000081567.3 ENSMUST00000081567.4 ENSMUST00000081567.5 ENSMUST00000081567.6 ENSMUST00000081567.7 ENSMUST00000081567.8 ENSMUST00000081567.9 MTF2_MOUSE NM_013827 Pcl2 Q02395 Q05C61 Q569Z8 Q6PG89 Q8BGP9 Q8BSJ7 uc008ynj.1 uc008ynj.2 uc008ynj.3 uc008ynj.4 Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:20144788, PubMed:21367819, PubMed:21059868, PubMed:23104054, PubMed:22438827). Regulates the transcriptional networks during embryonic stem cell self- renewal and differentiation (PubMed:20144788). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (PubMed:21367819). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (PubMed:21059868). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (PubMed:21059868). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (PubMed:7772254). Associates with the PRC2 complex, which consists of the core components EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:21367819, PubMed:22438827). Forms a dimeric PRC2.1 (class 1, PRC-PCL) complex consisting of at least SUZ12, RBBP4, and PHF19 or MTF2; PHF19 and MTF2 stabilize the dimeric structure which enhances PRC2 interaction with chromatin (By similarity). Q02395; Q921E6: Eed; NbExp=3; IntAct=EBI-2531578, EBI-904301; Q02395; P70351: Ezh1; NbExp=3; IntAct=EBI-2531578, EBI-2531737; Q02395; Q61188: Ezh2; NbExp=4; IntAct=EBI-2531578, EBI-904311; Nucleus Note=Localizes to chromatin as part of the PRC2 complex. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q02395-1; Sequence=Displayed; Name=2; IsoId=Q02395-2; Sequence=VSP_016240; The Tudor domain recognizes and binds H3K36me3. Mice survive to birth; however, most of them die before weaning. Axial skeletal alterations that are characteristic of posterior transformations are observed: ectopic ribs that associate with the seventh cervical vertebra (C7) are frequently observed. Consistent with this malformation, sternums are shifted anteriorly. The odontoid process, which is normally a characteristic of the second cervical vertebra (C2), is frequently associated with the first cervical vertebra (C1). Belongs to the Polycomblike family. Sequence=AAH24889.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH29076.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm focal adhesion chromatin organization segment specification stem cell population maintenance methylated histone binding sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding stem cell differentiation negative regulation of histone H3-K27 methylation positive regulation of histone H3-K27 methylation cellular response to leukemia inhibitory factor ESC/E(Z) complex nucleosome binding uc008ynj.1 uc008ynj.2 uc008ynj.3 uc008ynj.4 
ENSMUST00000081569.7 Nhs ENSMUST00000081569.7 NHS actin remodeling regulator, transcript variant 2 (from RefSeq NM_001081052.2) B9EJX2 B9EJX2_MOUSE ENSMUST00000081569.1 ENSMUST00000081569.2 ENSMUST00000081569.3 ENSMUST00000081569.4 ENSMUST00000081569.5 ENSMUST00000081569.6 NM_001081052 Nhs uc009uuc.1 uc009uuc.2 uc009uuc.3 uc009uuc.4 lens development in camera-type eye Golgi apparatus nuclear body cell junction cell differentiation uc009uuc.1 uc009uuc.2 uc009uuc.3 uc009uuc.4 
ENSMUST00000081574.8 Syt17 ENSMUST00000081574.8 synaptotagmin XVII, transcript variant 1 (from RefSeq NM_138649.3) Bk ENSMUST00000081574.1 ENSMUST00000081574.2 ENSMUST00000081574.3 ENSMUST00000081574.4 ENSMUST00000081574.5 ENSMUST00000081574.6 ENSMUST00000081574.7 NM_138649 Q3UXZ2 Q920M7 SYT17_MOUSE uc009jju.1 uc009jju.2 uc009jju.3 Plays a role in dendrite formation by melanocytes. Membrane ; Peripheral membrane protein Belongs to the synaptotagmin family. SNARE binding phosphatidylserine binding calcium ion binding calcium-dependent phospholipid binding trans-Golgi network plasma membrane regulation of dopamine secretion membrane vesicle-mediated transport calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis cell differentiation clathrin binding exocytic vesicle cellular response to calcium ion positive regulation of dendrite extension uc009jju.1 uc009jju.2 uc009jju.3 
ENSMUST00000081582.8 Zfp953 ENSMUST00000081582.8 zinc finger protein 953 (from RefSeq NM_001038651.3) ENSMUST00000081582.1 ENSMUST00000081582.2 ENSMUST00000081582.3 ENSMUST00000081582.4 ENSMUST00000081582.5 ENSMUST00000081582.6 ENSMUST00000081582.7 F7BUM8 F7BUM8_MOUSE NM_001038651 Zfp953 uc007raq.1 uc007raq.2 uc007raq.3 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. uc007raq.1 uc007raq.2 uc007raq.3 
ENSMUST00000081591.7 Zc3h15 ENSMUST00000081591.7 zinc finger CCCH-type containing 15 (from RefSeq NM_026934.3) Dfrp1 ENSMUST00000081591.1 ENSMUST00000081591.2 ENSMUST00000081591.3 ENSMUST00000081591.4 ENSMUST00000081591.5 ENSMUST00000081591.6 NM_026934 Q3TIV5 Q3TWQ0 Q3U855 Q8K2B6 Q8K346 Q9CVM4 Q9DAP2 ZC3HF_MOUSE uc008khy.1 uc008khy.2 uc008khy.3 uc008khy.4 Protects DRG1 from proteolytic degradation (PubMed:15676025). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (By similarity). Interacts with DRG1; the interaction forms a polysomal DRG1- DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination (PubMed:15676025). Associates with microtubules (By similarity). Cytoplasm. Nucleus Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TIV5-1; Sequence=Displayed; Name=2; IsoId=Q3TIV5-2; Sequence=VSP_032341; Name=3; IsoId=Q3TIV5-3; Sequence=VSP_032342, VSP_032343; By erythropoietin. Belongs to the ZC3H15/TMA46 family. Sequence=BAE31164.1; Type=Frameshift; Evidence=; cytoplasmic translation nucleus nucleolus cytoplasm cytosol cytokine-mediated signaling pathway positive regulation of GTPase activity metal ion binding uc008khy.1 uc008khy.2 uc008khy.3 uc008khy.4 
ENSMUST00000081593.13 Pgk1 ENSMUST00000081593.13 phosphoglycerate kinase 1 (from RefSeq NM_008828.3) ENSMUST00000081593.1 ENSMUST00000081593.10 ENSMUST00000081593.11 ENSMUST00000081593.12 ENSMUST00000081593.2 ENSMUST00000081593.3 ENSMUST00000081593.4 ENSMUST00000081593.5 ENSMUST00000081593.6 ENSMUST00000081593.7 ENSMUST00000081593.8 ENSMUST00000081593.9 NM_008828 P09411 PGK1_MOUSE Pgk-1 Q3TPE6 Q3UKV8 Q5XJE7 uc009ubo.1 uc009ubo.2 uc009ubo.3 The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Many pseudogenes of this gene are found throughout the mouse genome. [provided by RefSeq, Jan 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC108372.1, SRR1660815.59351.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## multifunctional gene product(s) :: PMID: 11130727 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. Reaction=(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP; Xref=Rhea:RHEA:14801, ChEBI:CHEBI:30616, ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216; EC=2.7.2.3; Evidence=; Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 2/5. Monomer. Cytoplasm Testis, lung, brain, skeletal muscle, liver, intestine, and kidney (at protein level). Belongs to the phosphoglycerate kinase family. nucleotide binding phosphoglycerate kinase activity ATP binding extracellular space cytoplasm cytosol carbohydrate metabolic process gluconeogenesis glycolytic process kinase activity phosphorylation negative regulation of angiogenesis transferase activity epithelial cell differentiation plasminogen activation ADP binding membrane raft protein-disulfide reductase activity oxidation-reduction process cellular response to hypoxia positive regulation of oxidative phosphorylation uc009ubo.1 uc009ubo.2 uc009ubo.3 
ENSMUST00000081619.10 Sh3pxd2a ENSMUST00000081619.10 SH3 and PX domains 2A, transcript variant 1 (from RefSeq NM_008018.5) E9QKJ2 ENSMUST00000081619.1 ENSMUST00000081619.2 ENSMUST00000081619.3 ENSMUST00000081619.4 ENSMUST00000081619.5 ENSMUST00000081619.6 ENSMUST00000081619.7 ENSMUST00000081619.8 ENSMUST00000081619.9 Fish NM_008018 O89032 Q148Q8 SPD2A_MOUSE Sh3md1 Tks5 uc008huz.1 uc008huz.2 uc008huz.3 uc008huz.4 Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide (By similarity). Interacts with ADAM12, ADAM15 and ADAM19 (By similarity). Interacts with NOXO1 (By similarity). Interacts (via SH3 domains) with NOXA1; the interaction is direct (By similarity). Interacts (via N- terminus) with CYBA. Interacts with FASLG (By similarity). Cytoplasm. Cell projection, podosome Note=Cytoplasmic in normal cells and localizes to podosomes in Src-transformed cells. Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=O89032-1; Sequence=Displayed; Name=2; IsoId=O89032-2; Sequence=VSP_023315; Name=3; IsoId=O89032-3; Sequence=VSP_023314, VSP_023315; Widely expressed. Not found in the spleen and testis. The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain (By similarity). The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19. Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR (By similarity). Shows significant decrease in total cellular reactive oxygen species (ROS) and in podosome formation. Belongs to the SH3PXD2 family. Sequence=AAI18023.1; Type=Frameshift; Evidence=; in utero embryonic development protease binding podosome protein binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm superoxide metabolic process phosphatidylinositol-5-phosphate binding superoxide-generating NADPH oxidase activator activity cell junction phosphatidylinositol-3-phosphate binding phosphatidylinositol binding cell projection positive regulation of catalytic activity phosphatidylinositol-3,4-bisphosphate binding phosphatidylinositol-4-phosphate binding reactive oxygen species metabolic process osteoclast fusion uc008huz.1 uc008huz.2 uc008huz.3 uc008huz.4 
ENSMUST00000081631.10 Mettl15 ENSMUST00000081631.10 methyltransferase like 15, transcript variant 1 (from RefSeq NM_029790.4) ENSMUST00000081631.1 ENSMUST00000081631.2 ENSMUST00000081631.3 ENSMUST00000081631.4 ENSMUST00000081631.5 ENSMUST00000081631.6 ENSMUST00000081631.7 ENSMUST00000081631.8 ENSMUST00000081631.9 MET15_MOUSE Mett5d1 Mettl15 NM_029790 Q3KQI4 Q9DCL4 uc008llv.1 uc008llv.2 uc008llv.3 N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA. Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits. Reaction=cytidine(839) in 12S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:62524, Rhea:RHEA-COMP:16109, Rhea:RHEA-COMP:16110, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74506, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62525; Evidence=; Mitochondrion matrix Belongs to the methyltransferase superfamily. RsmH family. cellular_component methyltransferase activity transferase activity methylation rRNA base methylation rRNA (cytosine-N4-)-methyltransferase activity uc008llv.1 uc008llv.2 uc008llv.3 
ENSMUST00000081649.10 Ifitm2 ENSMUST00000081649.10 interferon induced transmembrane protein 2 (from RefSeq NM_030694.2) ENSMUST00000081649.1 ENSMUST00000081649.2 ENSMUST00000081649.3 ENSMUST00000081649.4 ENSMUST00000081649.5 ENSMUST00000081649.6 ENSMUST00000081649.7 ENSMUST00000081649.8 ENSMUST00000081649.9 IFM2_MOUSE NM_030694 Q3TIG4 Q99J93 uc009kiz.1 uc009kiz.2 uc009kiz.3 IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein- mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. Interacts with CD81. Cell membrane ; Single-pass type II membrane protein Lysosome membrane ; Single-pass type II membrane protein Late endosome membrane ; Single-pass type II membrane protein Predominantly expressed in nascent primordial germ cells, as well as in gonadal germ cells. From 5.5 dpc to 7.5 dpc expressed within the epiblast. At 8.5 dpc expressed throughout the entire embryo. Expressed in the gonadal germ cells at 11.5 dpc/12.5. Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity. Phosphorylation at Tyr-19 is required for endosomal and lysosomal location. Belongs to the CD225/Dispanin family. immune system process molecular_function plasma membrane heart development response to virus membrane integral component of membrane macromolecular complex response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication innate immune response negative regulation of viral entry into host cell defense response to virus type I interferon signaling pathway uc009kiz.1 uc009kiz.2 uc009kiz.3 
ENSMUST00000081650.15 Rpl3 ENSMUST00000081650.15 ribosomal protein L3, transcript variant 1 (from RefSeq NM_013762.3) ENSMUST00000081650.1 ENSMUST00000081650.10 ENSMUST00000081650.11 ENSMUST00000081650.12 ENSMUST00000081650.13 ENSMUST00000081650.14 ENSMUST00000081650.2 ENSMUST00000081650.3 ENSMUST00000081650.4 ENSMUST00000081650.5 ENSMUST00000081650.6 ENSMUST00000081650.7 ENSMUST00000081650.8 ENSMUST00000081650.9 NM_013762 O89071 P27659 Q91VJ6 RL3_MOUSE uc007wvb.1 uc007wvb.2 uc007wvb.3 uc007wvb.4 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit (PubMed:36517592). Interacts with DHX33 (PubMed:26100019). Nucleus, nucleolus Cytoplasm Constitutively monomethylated at His-245 by METTL18. Methylation at His-245 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins. It is not required for incorporation of RPL3 into ribosomes. Belongs to the universal ribosomal protein uL3 family. ribosomal large subunit assembly structural constituent of ribosome nucleus nucleolus cytoplasm cytosol ribosome translation 5S rRNA binding cytosolic large ribosomal subunit macromolecular complex synapse cellular response to interleukin-4 uc007wvb.1 uc007wvb.2 uc007wvb.3 uc007wvb.4 
ENSMUST00000081657.6 Lypd11 ENSMUST00000081657.6 Ly6/PLAUR domain containing 11, transcript variant 1 (from RefSeq NM_177593.1) EG210155 ENSMUST00000081657.1 ENSMUST00000081657.2 ENSMUST00000081657.3 ENSMUST00000081657.4 ENSMUST00000081657.5 Gm4763 Lypd11 NM_177593 Q8CFJ5 Q8CFJ5_MOUSE uc009fqk.1 uc009fqk.2 molecular_function cellular_component biological_process uc009fqk.1 uc009fqk.2 
ENSMUST00000081677.12 Ppil3 ENSMUST00000081677.12 peptidylprolyl isomerase (cyclophilin)-like 3, transcript variant 1 (from RefSeq NM_027351.3) Cyp10l ENSMUST00000081677.1 ENSMUST00000081677.10 ENSMUST00000081677.11 ENSMUST00000081677.2 ENSMUST00000081677.3 ENSMUST00000081677.4 ENSMUST00000081677.5 ENSMUST00000081677.6 ENSMUST00000081677.7 ENSMUST00000081677.8 ENSMUST00000081677.9 NM_027351 PPIL3_MOUSE Q812D2 Q9CY23 Q9D6L8 uc007bbx.1 uc007bbx.2 uc007bbx.3 uc007bbx.4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity). Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Identified in the spliceosome C complex. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D6L8-1; Sequence=Displayed; Name=2; IsoId=Q9D6L8-2; Sequence=VSP_015469; Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily. protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity spliceosomal complex mRNA processing protein folding RNA splicing isomerase activity catalytic step 2 spliceosome uc007bbx.1 uc007bbx.2 uc007bbx.3 uc007bbx.4 
ENSMUST00000081684.3 Ifnl2 ENSMUST00000081684.3 interferon lambda 2 (from RefSeq NM_001024673.2) E9Q2S2 ENSMUST00000081684.1 ENSMUST00000081684.2 IFNL2_MOUSE Il28a NM_001024673 Q4VK74 uc009fzd.1 uc009fzd.2 uc009fzd.3 Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)- induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. Secreted Belongs to the lambda interferon family. mucosal immune response receptor binding cytokine activity extracellular region extracellular space JAK-STAT cascade innate immune response positive regulation of immune response defense response to virus uc009fzd.1 uc009fzd.2 uc009fzd.3 
ENSMUST00000081702.12 Trabd ENSMUST00000081702.12 TraB domain containing, transcript variant 1 (from RefSeq NM_026485.2) ENSMUST00000081702.1 ENSMUST00000081702.10 ENSMUST00000081702.11 ENSMUST00000081702.2 ENSMUST00000081702.3 ENSMUST00000081702.4 ENSMUST00000081702.5 ENSMUST00000081702.6 ENSMUST00000081702.7 ENSMUST00000081702.8 ENSMUST00000081702.9 NM_026485 Q99JY4 Q9CYF1 TRABD_MOUSE uc007xfc.1 uc007xfc.2 uc007xfc.3 molecular_function cellular_component biological_process uc007xfc.1 uc007xfc.2 uc007xfc.3 
ENSMUST00000081703.8 Ceacam13 ENSMUST00000081703.8 CEA cell adhesion molecule 13, transcript variant 2 (from RefSeq NM_028171.2) Ceacam13 ENSMUST00000081703.1 ENSMUST00000081703.2 ENSMUST00000081703.3 ENSMUST00000081703.4 ENSMUST00000081703.5 ENSMUST00000081703.6 ENSMUST00000081703.7 NM_028171 Q9DAT7 Q9DAT7_MOUSE uc009fjd.1 uc009fjd.2 molecular_function cellular_component biological_process uc009fjd.1 uc009fjd.2 
ENSMUST00000081714.5 Hoga1 ENSMUST00000081714.5 4-hydroxy-2-oxoglutarate aldolase 1 (from RefSeq NM_026152.2) Dhdpsl ENSMUST00000081714.1 ENSMUST00000081714.2 ENSMUST00000081714.3 ENSMUST00000081714.4 HOGA1_MOUSE NM_026152 Q91W74 Q9CY60 Q9DCU9 uc008hnb.1 uc008hnb.2 uc008hnb.3 Catalyzes the final step in the metabolic pathway of hydroxyproline. Reaction=(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate; Xref=Rhea:RHEA:35639, ChEBI:CHEBI:15361, ChEBI:CHEBI:36655, ChEBI:CHEBI:71685; EC=4.1.3.16; Reaction=(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate; Xref=Rhea:RHEA:30687, ChEBI:CHEBI:15361, ChEBI:CHEBI:36655, ChEBI:CHEBI:62213; EC=4.1.3.16; Inhibited by divalent cations. Homotetramer. Mitochondrion Belongs to the DapA family. Sequence=AAH16430.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; Sequence=BAB27226.1; Type=Frameshift; Evidence=; catalytic activity mitochondrion 4-hydroxy-2-oxoglutarate aldolase activity glyoxylate catabolic process lyase activity 4-hydroxyproline catabolic process oxalate metabolic process protein homodimerization activity pyruvate biosynthetic process glyoxylate metabolic process uc008hnb.1 uc008hnb.2 uc008hnb.3 
ENSMUST00000081721.13 Ezh2 ENSMUST00000081721.13 enhancer of zeste 2 polycomb repressive complex 2 subunit, transcript variant 30 (from RefSeq NR_176903.1) ENSMUST00000081721.1 ENSMUST00000081721.10 ENSMUST00000081721.11 ENSMUST00000081721.12 ENSMUST00000081721.2 ENSMUST00000081721.3 ENSMUST00000081721.4 ENSMUST00000081721.5 ENSMUST00000081721.6 ENSMUST00000081721.7 ENSMUST00000081721.8 ENSMUST00000081721.9 EZH2_MOUSE Enx1h Ezh2 NR_176903 Q61188 Q99L74 Q9R090 uc009btb.1 uc009btb.2 uc009btb.3 uc009btb.4 Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. EZH2 can also methylate non- histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK- BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA- COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356; Evidence=; Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2 (By similarity). The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12 (By similarity). The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit (By similarity). Interacts with HDAC1 and HDAC2 (By similarity). Binds ATRX via the SET domain (By similarity). Interacts with PRAME (By similarity). Interacts with CDYL (By similarity). Interacts with EED. Interacts with BMAL1. Interacts with CLOCK and CRY1. Interacts with DNMT3L; the interaction is direct (PubMed:24074865). Interacts with EZHIP; the interaction blocks EZH2 methyltransferase activity (PubMed:31451685). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (By similarity). Interacts with ARMC12 (By similarity). Interacts with ZMYND8; the interaction is dependent on the presence of chromatin (By similarity). Q61188; Q9CWR8: Dnmt3l; NbExp=10; IntAct=EBI-904311, EBI-3043871; Q61188; Q921E6: Eed; NbExp=9; IntAct=EBI-904311, EBI-904301; Q61188; Q62315: Jarid2; NbExp=15; IntAct=EBI-904311, EBI-493592; Q61188; Q02395: Mtf2; NbExp=4; IntAct=EBI-904311, EBI-2531578; Q61188; Q80U70: Suz12; NbExp=10; IntAct=EBI-904311, EBI-2526494; Q61188; P38398: BRCA1; Xeno; NbExp=5; IntAct=EBI-904311, EBI-349905; Q61188-1; Q921E6: Eed; NbExp=5; IntAct=EBI-15665134, EBI-904301; Nucleus Chromosome. Note=Localizes to the inactive X chromosome in trophoblast stem cells. Event=Alternative splicing; Named isoforms=2; Name=ENX-1A; IsoId=Q61188-1; Sequence=Displayed; Name=ENX-1B; IsoId=Q61188-2; Sequence=VSP_001501; Present in actively dividing cells (PubMed:19026781). Widely expressed in early embryos (PubMed:19026781). In later embryogenesis, expression restricted to central and peripheral nervous system, liver and thymus (PubMed:19026781). In adult, highest expression in spleen, testis and placenta (PubMed:19026781, PubMed:31451685). Lower levels in intestine, muscle and ovary and very low levels in brain and liver (PubMed:19026781, PubMed:31451685). No expression in heart, thyroid gland, lung and kidney (PubMed:19026781). Expressed in both adult and embryo with highest levels in early embryogenesis. Expressed in the fertilized oocyte. Expression decreases during differentiation of ES cells and during senescence of MEFs. Expression increases in prostate during prostate tumor development. Repressed by the microRNA (miRNA) miR-26a. Phosphorylated by AKT1 (By similarity). Phosphorylation by AKT1 reduces methyltransferase activity. Phosphorylation at Thr-345 by CDK1 and CDK2 promotes maintenance of H3K27me3 levels at EZH2-target loci, thus leading to epigenetic gene silencing (By similarity). Sumoylated. Glycosylated: O-GlcNAcylation at Ser-75 by OGT increases stability of EZH2 and facilitates the formation of H3K27me3 by the PRC2/EED-EZH2 complex. Death early in development. Embryos cease development following implantation or initiate but fail to complete gastrulation. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily. Sequence=AAD54020.1; Type=Erroneous gene model prediction; Evidence=; negative regulation of transcription from RNA polymerase II promoter chromosome, telomeric region nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding regulation of protein phosphorylation chromatin binding transcription corepressor activity RNA binding protein binding nucleus nucleoplasm chromosome cytoplasm DNA methylation chromatin organization chromatin silencing at telomere regulation of transcription from RNA polymerase II promoter methyltransferase activity positive regulation of cell proliferation regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition regulation of gliogenesis skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration cardiac muscle hypertrophy in response to stress protein-lysine N-methyltransferase activity histone methylation transferase activity histone-lysine N-methyltransferase activity cerebellar cortex development hippocampus development chromatin DNA binding methylation response to estradiol negative regulation of transcription elongation from RNA polymerase II promoter ESC/E(Z) complex cellular response to trichostatin A hepatocyte homeostasis histone methyltransferase activity regulation of cell proliferation regulation of circadian rhythm ribonucleoprotein complex binding positive regulation of MAP kinase activity negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of GTPase activity sequence-specific DNA binding transcription regulatory region DNA binding pronucleus negative regulation of epidermal cell differentiation negative regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated histone methyltransferase activity (H3-K27 specific) negative regulation of retinoic acid receptor signaling pathway rhythmic process regulation of neurogenesis negative regulation of striated muscle cell differentiation cellular response to hydrogen peroxide G1 to G0 transition histone H3-K27 methylation primary miRNA binding protein localization to chromatin positive regulation of protein serine/threonine kinase activity liver regeneration histone H3-K27 trimethylation positive regulation of dendrite development positive regulation of cell cycle G1/S phase transition response to tetrachloromethane promoter-specific chromatin binding negative regulation of G1/S transition of mitotic cell cycle uc009btb.1 uc009btb.2 uc009btb.3 uc009btb.4 
ENSMUST00000081726.13 Eya3 ENSMUST00000081726.13 EYA transcriptional coactivator and phosphatase 3, transcript variant 1 (from RefSeq NM_210071.3) ENSMUST00000081726.1 ENSMUST00000081726.10 ENSMUST00000081726.11 ENSMUST00000081726.12 ENSMUST00000081726.2 ENSMUST00000081726.3 ENSMUST00000081726.4 ENSMUST00000081726.5 ENSMUST00000081726.6 ENSMUST00000081726.7 ENSMUST00000081726.8 ENSMUST00000081726.9 Eya3 NM_210071 Q6P4T3 Q6P4T3_MOUSE uc008vbp.1 uc008vbp.2 uc008vbp.3 Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Note=Binds 1 Mg(2+) ion per subunit. Nucleus Belongs to the HAD-like hydrolase superfamily. EYA family. phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding nucleus nucleoplasm transcription factor complex centrosome double-strand break repair multicellular organism development response to ionizing radiation histone dephosphorylation hydrolase activity peptidyl-tyrosine dephosphorylation positive regulation of DNA repair metal ion binding uc008vbp.1 uc008vbp.2 uc008vbp.3 
ENSMUST00000081742.7 Zfp985 ENSMUST00000081742.7 zinc finger protein 985 (from RefSeq NM_001014397.4) A2A7A5 A2A7A5_MOUSE ENSMUST00000081742.1 ENSMUST00000081742.2 ENSMUST00000081742.3 ENSMUST00000081742.4 ENSMUST00000081742.5 ENSMUST00000081742.6 NM_001014397 Zfp985 uc008vsy.1 uc008vsy.2 uc008vsy.3 uc008vsy.4 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008vsy.1 uc008vsy.2 uc008vsy.3 uc008vsy.4 
ENSMUST00000081743.3 Or2t49 ENSMUST00000081743.3 olfactory receptor family 2 subfamily T member 49 (from RefSeq NM_001011861.3) ENSMUST00000081743.1 ENSMUST00000081743.2 NM_001011861 Olfr331 Or2t49 Q5NC44 Q5NC44_MOUSE uc029rlv.1 uc029rlv.2 uc029rlv.3 uc029rlv.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Feb 2012]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc029rlv.1 uc029rlv.2 uc029rlv.3 uc029rlv.4 
ENSMUST00000081746.7 Atosa ENSMUST00000081746.7 atos homolog A, transcript variant 2 (from RefSeq NM_153584.2) ATOSA_MOUSE E9PX00 ENSMUST00000081746.1 ENSMUST00000081746.2 ENSMUST00000081746.3 ENSMUST00000081746.4 ENSMUST00000081746.5 ENSMUST00000081746.6 Fam214a Kiaa1370 NM_153584 Q69ZK7 Q8K0I6 Q8K266 uc009qrl.1 uc009qrl.2 uc009qrl.3 uc009qrl.4 Transcription regulator that syncronizes transcriptional and translational programs to promote macrophage invasion of tissues. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69ZK7-1; Sequence=Displayed; Name=2; IsoId=Q69ZK7-2; Sequence=VSP_030582; The protein contains 2 transactivation domains (TAD). Each of these domains may be required for transcriptional activation of a subset of target genes. Belongs to the ATOS family. Sequence=AAH32966.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32439.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process uc009qrl.1 uc009qrl.2 uc009qrl.3 uc009qrl.4 
ENSMUST00000081747.8 0610040J01Rik ENSMUST00000081747.8 RIKEN cDNA 0610040J01 gene, transcript variant 1 (from RefSeq NM_029554.5) CD019_MOUSE ENSMUST00000081747.1 ENSMUST00000081747.2 ENSMUST00000081747.3 ENSMUST00000081747.4 ENSMUST00000081747.5 ENSMUST00000081747.6 ENSMUST00000081747.7 NM_029554 Q8BQG8 Q99K99 Q9DCE0 uc008xmg.1 uc008xmg.2 uc008xmg.3 molecular_function nucleoplasm biological_process cell junction uc008xmg.1 uc008xmg.2 uc008xmg.3 
ENSMUST00000081748.6 Or51b17 ENSMUST00000081748.6 olfactory receptor family 51 subfamily B member 17 (from RefSeq NM_013617.3) ENSMUST00000081748.1 ENSMUST00000081748.2 ENSMUST00000081748.3 ENSMUST00000081748.4 ENSMUST00000081748.5 F8VPZ8 F8VPZ8_MOUSE NM_013617 Olfr64 Or51b17 uc009iuv.1 uc009iuv.2 uc009iuv.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009iuv.1 uc009iuv.2 uc009iuv.3 
ENSMUST00000081752.13 Olfm3 ENSMUST00000081752.13 olfactomedin 3, transcript variant 1 (from RefSeq NM_153458.3) ENSMUST00000081752.1 ENSMUST00000081752.10 ENSMUST00000081752.11 ENSMUST00000081752.12 ENSMUST00000081752.2 ENSMUST00000081752.3 ENSMUST00000081752.4 ENSMUST00000081752.5 ENSMUST00000081752.6 ENSMUST00000081752.7 ENSMUST00000081752.8 ENSMUST00000081752.9 NM_153458 Olfm3 Q3UVC5 Q3UVC5_MOUSE uc008rbm.1 uc008rbm.2 uc008rbm.3 uc008rbm.4 Secreted Synapse uc008rbm.1 uc008rbm.2 uc008rbm.3 uc008rbm.4 
ENSMUST00000081769.13 Edil3 ENSMUST00000081769.13 EGF-like repeats and discoidin I-like domains 3, transcript variant 1 (from RefSeq NM_001037987.4) Del1 EDIL3_MOUSE ENSMUST00000081769.1 ENSMUST00000081769.10 ENSMUST00000081769.11 ENSMUST00000081769.12 ENSMUST00000081769.2 ENSMUST00000081769.3 ENSMUST00000081769.4 ENSMUST00000081769.5 ENSMUST00000081769.6 ENSMUST00000081769.7 ENSMUST00000081769.8 ENSMUST00000081769.9 NM_001037987 O35474 O35475 Q8CBF7 uc007rjd.1 uc007rjd.2 uc007rjd.3 uc007rjd.4 Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development. Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=O35474-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=O35474-2; Sequence=VSP_050400, VSP_050401; Expressed in angioblasts and early endothelial cells. By embryonic day 13.5, also expressed in a restricted group of non-endothelial cells including chondrocytes and retinal neurons. Expressed in the embryo from day 7. After day 15.5, expression decreases and disappears completely by the time of birth. EGF2 and EGF3 form a rigid rod via an interdomain calcium ion binding site, while the long linker between EGF1 and EGF2 lends considerable flexibility to EGF1. integrin binding calcium ion binding extracellular region cell adhesion multicellular organism development positive regulation of cell-substrate adhesion metal ion binding uc007rjd.1 uc007rjd.2 uc007rjd.3 uc007rjd.4 
ENSMUST00000081775.12 Nfe2l1 ENSMUST00000081775.12 nuclear factor, erythroid derived 2,-like 1, transcript variant 1 (from RefSeq NM_008686.3) ENSMUST00000081775.1 ENSMUST00000081775.10 ENSMUST00000081775.11 ENSMUST00000081775.2 ENSMUST00000081775.3 ENSMUST00000081775.4 ENSMUST00000081775.5 ENSMUST00000081775.6 ENSMUST00000081775.7 ENSMUST00000081775.8 ENSMUST00000081775.9 NM_008686 Nfe2l1 Q6GTN8 Q6GTN8_MOUSE uc007lcr.1 uc007lcr.2 uc007lcr.3 This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases from the use of NRF1 for this gene, NFE2L1, and for 'nuclear respiratory factor 1' which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Endoplasmic reticulum membrane ; Single-pass type III membrane protein Membrane ; Single-pass type II membrane protein Membrane ; Single-pass type III membrane protein Nucleus Belongs to the bZIP family. CNC subfamily. DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytosol regulation of transcription, DNA-templated cellular response to oxidative stress uc007lcr.1 uc007lcr.2 uc007lcr.3 
ENSMUST00000081776.11 Apol9a ENSMUST00000081776.11 apolipoprotein L 9a, transcript variant 4 (from RefSeq NM_001416011.1) Apol9a Apol9b BC020489 ENSMUST00000081776.1 ENSMUST00000081776.10 ENSMUST00000081776.2 ENSMUST00000081776.3 ENSMUST00000081776.4 ENSMUST00000081776.5 ENSMUST00000081776.6 ENSMUST00000081776.7 ENSMUST00000081776.8 ENSMUST00000081776.9 NM_001416011 Q8VDU3 Q8VDU3_MOUSE uc007wno.1 uc007wno.2 uc007wno.3 uc007wno.4 Belongs to the apolipoprotein L family. cellular_component extracellular region lipid transport biological_process lipid binding lipoprotein metabolic process uc007wno.1 uc007wno.2 uc007wno.3 uc007wno.4 
ENSMUST00000081777.8 Mug2 ENSMUST00000081777.8 murinoglobulin 2 (from RefSeq NM_008646.3) ENSMUST00000081777.1 ENSMUST00000081777.2 ENSMUST00000081777.3 ENSMUST00000081777.4 ENSMUST00000081777.5 ENSMUST00000081777.6 ENSMUST00000081777.7 MUG2_MOUSE Mug-2 NM_008646 P28666 uc009dos.1 uc009dos.2 uc009dos.3 A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective. Monomer. Secreted. Plasma. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. protease binding endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity extracellular region extracellular space negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc009dos.1 uc009dos.2 uc009dos.3 
ENSMUST00000081780.4 Tdpoz3 ENSMUST00000081780.4 TD and POZ domain containing 3 (from RefSeq NM_207271.2) E9QKH5 ENSMUST00000081780.1 ENSMUST00000081780.2 ENSMUST00000081780.3 NM_207271 Q717B4 TDPZ3_MOUSE Tdpoz3 uc008qfo.1 uc008qfo.2 Strongly expressed in 2-cell embryos with weak expression detected in other embryonic stages. Also weakly expressed in adult testis. Belongs to the Tdpoz family. nucleus cytoplasm ubiquitin-dependent protein catabolic process regulation of proteolysis ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process uc008qfo.1 uc008qfo.2 
ENSMUST00000081790.15 Cacul1 ENSMUST00000081790.15 CDK2 associated, cullin domain 1, transcript variant 1 (from RefSeq NM_030197.3) CACL1_MOUSE ENSMUST00000081790.1 ENSMUST00000081790.10 ENSMUST00000081790.11 ENSMUST00000081790.12 ENSMUST00000081790.13 ENSMUST00000081790.14 ENSMUST00000081790.2 ENSMUST00000081790.3 ENSMUST00000081790.4 ENSMUST00000081790.5 ENSMUST00000081790.6 ENSMUST00000081790.7 ENSMUST00000081790.8 ENSMUST00000081790.9 NM_030197 Q3TE79 Q8R0X2 Q9CY95 uc008ibv.1 uc008ibv.2 uc008ibv.3 uc008ibv.4 Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. Interacts with CDK2. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R0X2-1; Sequence=Displayed; Name=2; IsoId=Q8R0X2-2; Sequence=VSP_013938, VSP_013939; Belongs to the cullin family. G1/S transition of mitotic cell cycle ubiquitin-dependent protein catabolic process cell cycle positive regulation of cell proliferation protein kinase binding ubiquitin protein ligase binding positive regulation of protein kinase activity uc008ibv.1 uc008ibv.2 uc008ibv.3 uc008ibv.4 
ENSMUST00000081799.6 Sgsm2 ENSMUST00000081799.6 small G protein signaling modulator 2, transcript variant 2 (from RefSeq NM_001374688.1) ENSMUST00000081799.1 ENSMUST00000081799.2 ENSMUST00000081799.3 ENSMUST00000081799.4 ENSMUST00000081799.5 Kiaa0397 NM_001374688 Q5SWE0 Q5SWE1 Q6PAP8 Q80U12 Rutbc1 SGSM2_MOUSE uc288acx.1 uc288acx.2 Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560). Interacts with RAB4A, RAB11A, RAP1A, RAP1B, RAP2A and RAP2B. No interaction with RAB27A. Interacts with RAB9A (By similarity). Cytoplasm Melanosome Note=Melanosomal localization is mediated by RAB9A. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80U12-1; Sequence=Displayed; Name=2; IsoId=Q80U12-2; Sequence=VSP_024599; Widely expressed. The Rab-GAP TBC domain possesses GTPase activator activity. Belongs to the RUTBC family. Sequence=AAH58414.1; Type=Frameshift; Evidence=; Sequence=AAH60163.1; Type=Frameshift; Evidence=; Sequence=BAC65555.1; Type=Erroneous initiation; Evidence=; GTPase activator activity cytoplasm intracellular protein transport Rab GTPase binding late endosome to Golgi transport melanosome positive regulation of GTPase activity activation of GTPase activity uc288acx.1 uc288acx.2 
ENSMUST00000081816.11 Bpifb1 ENSMUST00000081816.11 BPI fold containing family B, member 1, transcript variant 1 (from RefSeq NM_001012392.1) A2AJD5 BPIB1_MOUSE ENSMUST00000081816.1 ENSMUST00000081816.10 ENSMUST00000081816.2 ENSMUST00000081816.3 ENSMUST00000081816.4 ENSMUST00000081816.5 ENSMUST00000081816.6 ENSMUST00000081816.7 ENSMUST00000081816.8 ENSMUST00000081816.9 Lplunc1 NM_001012392 Q497Q1 Q4VC32 Q61114 uc008niw.1 uc008niw.2 uc008niw.3 May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS. May be involved in formation of the left-right axis in the node of the developing embryo. Secreted Expressed in tongue, lung, thymus, and stomach. Expressed in epithelia of palate, anterior pharynx, trachea and upper bronchi. Expressed in distal tip of papillae in the anterior third of the tongue and in serous cells of von Ebner glands in the posterior third of the tongue. Expressed in columnar epithelium of the duodenum in embryonic gut at 16.5 dpc. Detectable in crown cells of the embryonic node from 7.5 dpc. Initial uniform expression develops asymmetrically with a higher level on the left side of the node until expression disappears around 13.5 dpc. Expressed in antrum pyloricum of the stomach from 11.5 dpc to 16.5 dpc and in dorsal tongue epithelium from 14.5 dpc to 16.5 dpc. Asymmetric expression in the embryonic node is dependent on Invs and Dnahc11. Belongs to the BPI/LBP/Plunc superfamily. Plunc family. Sequence=AAA87581.3; Type=Frameshift; Evidence=; innate immune response in mucosa immune system process extracellular region extracellular space lipid binding negative regulation of toll-like receptor 4 signaling pathway innate immune response uc008niw.1 uc008niw.2 uc008niw.3 
ENSMUST00000081828.13 Bbof1 ENSMUST00000081828.13 basal body orientation factor 1 (from RefSeq NM_028377.3) B9EKT3 BBOF1_MOUSE Bbof1 Ccdc176 ENSMUST00000081828.1 ENSMUST00000081828.10 ENSMUST00000081828.11 ENSMUST00000081828.12 ENSMUST00000081828.2 ENSMUST00000081828.3 ENSMUST00000081828.4 ENSMUST00000081828.5 ENSMUST00000081828.6 ENSMUST00000081828.7 ENSMUST00000081828.8 ENSMUST00000081828.9 NM_028377 Q3V079 Q9CUZ3 uc007ofi.1 uc007ofi.2 uc007ofi.3 uc007ofi.4 Plays an essential role in sperm motility and male fertility by stabilizing the sperm flagellar axonemal structure. May be required for the stability of ODF2 and MANS1 proteins. Dispensable for the assembly and function of motile cilia. Interacts with MNS1 and ODF2. Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, flagellum axoneme Note=Localizes to a polar structure adjacent to the basal body. Expressed exclusively in the testis and predominantly expressed in male germ cells. First detected at PD16 (postnatal day 16), when the first wave of spermatocytes enter the pachytene stage, and expression increases with testis development from PD18 to PD69. Mice show reduced sperm motility and male subfertility without obvious sperm morphological defects. Abnormalities in sperm flagellar axoneme seen, with an absence of one to three microtubule doublets in the principal piece and end piece of the sperm flagellum. Motile cilia are normally distributed on the epithelial cells of the trachea and the axonemal structure of cilia is intact. Belongs to the BBOF1 family. molecular_function cellular_component cytoplasm cytoskeleton cilium biological_process ciliary basal body cell projection motile cilium assembly uc007ofi.1 uc007ofi.2 uc007ofi.3 uc007ofi.4 
ENSMUST00000081834.10 Armcx3 ENSMUST00000081834.10 armadillo repeat containing, X-linked 3, transcript variant 1 (from RefSeq NM_027870.4) A2AKS4 ARMX3_MOUSE Alex3 ENSMUST00000081834.1 ENSMUST00000081834.2 ENSMUST00000081834.3 ENSMUST00000081834.4 ENSMUST00000081834.5 ENSMUST00000081834.6 ENSMUST00000081834.7 ENSMUST00000081834.8 ENSMUST00000081834.9 NM_027870 Q8BHS6 Q91VP8 Q9DC32 uc009ugo.1 uc009ugo.2 uc009ugo.3 uc009ugo.4 Regulates mitochondrial aggregation and transport in axons in living neurons (PubMed:22569362, PubMed:23844091). May link mitochondria to the Trak2-kinesin motor complex via its interaction with Miro and Trak2 (PubMed:22569362). Mitochondrial distribution and dynamics is regulated through Armcx3 protein degradation, which is promoted by PCK and negatively regulated by Wnt1 (PubMed:23844091). Enhances the Sox10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters (PubMed:19304657). Interacts (via ARM domain) with MIRO1, MIRO2 and TRAK2. The interaction with Miro is calcium-dependent (PubMed:22569362). Interacts with Sox10 (PubMed:19304657). Mitochondrion outer membrane ; Single-pass membrane protein Cytoplasm Nucleus Highly expressed in the developing neural tissues, neural crest derivatives and hind limbs. Also widely expressed in the adult nervous tissue, especially in the forebrain, including the cerebral cortex, hippocampus and thalamus. Belongs to the eutherian X-chromosome-specific Armcx family. protein binding nucleus cytoplasm mitochondrion mitochondrial outer membrane membrane integral component of membrane integral component of mitochondrial outer membrane cellular protein localization positive regulation of transcription from RNA polymerase II promoter uc009ugo.1 uc009ugo.2 uc009ugo.3 uc009ugo.4 
ENSMUST00000081840.6 Rpl32 ENSMUST00000081840.6 ribosomal protein L32 (from RefSeq NM_172086.2) ENSMUST00000081840.1 ENSMUST00000081840.2 ENSMUST00000081840.3 ENSMUST00000081840.4 ENSMUST00000081840.5 NM_172086 P02433 P62911 Q3UFJ7 RL32_MOUSE uc009djc.1 uc009djc.2 uc009djc.3 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Cytoplasm Belongs to the eukaryotic ribosomal protein eL32 family. structural constituent of ribosome ribosome translation cytosolic large ribosomal subunit cellular response to dexamethasone stimulus liver regeneration uc009djc.1 uc009djc.2 uc009djc.3 
ENSMUST00000081848.13 Fdps ENSMUST00000081848.13 farnesyl diphosphate synthetase, transcript variant 2 (from RefSeq NM_134469.4) ENSMUST00000081848.1 ENSMUST00000081848.10 ENSMUST00000081848.11 ENSMUST00000081848.12 ENSMUST00000081848.2 ENSMUST00000081848.3 ENSMUST00000081848.4 ENSMUST00000081848.5 ENSMUST00000081848.6 ENSMUST00000081848.7 ENSMUST00000081848.8 ENSMUST00000081848.9 FPPS_MOUSE NM_134469 Q920E5 uc008pxo.1 uc008pxo.2 uc008pxo.3 uc008pxo.4 Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). Reaction=dimethylallyl diphosphate + isopentenyl diphosphate = (2E)- geranyl diphosphate + diphosphate; Xref=Rhea:RHEA:22408, ChEBI:CHEBI:33019, ChEBI:CHEBI:57623, ChEBI:CHEBI:58057, ChEBI:CHEBI:128769; EC=2.5.1.1; Reaction=(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)- farnesyl diphosphate + diphosphate; Xref=Rhea:RHEA:19361, ChEBI:CHEBI:33019, ChEBI:CHEBI:58057, ChEBI:CHEBI:128769, ChEBI:CHEBI:175763; EC=2.5.1.10; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 Mg(2+) ions per subunit. ; Inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell (By similarity). Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1. Homodimer. Interacts with RSAD2 (By similarity). Cytoplasm Belongs to the FPP/GGPP synthase family. dimethylallyltranstransferase activity geranyltranstransferase activity nucleoplasm cytoplasm mitochondrion mitochondrial matrix peroxisome cytosol lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process steroid metabolic process cholesterol metabolic process isoprenoid biosynthetic process sterol biosynthetic process transferase activity geranyl diphosphate biosynthetic process farnesyl diphosphate biosynthetic process positive regulation of cholesterol biosynthetic process metal ion binding positive regulation of cell growth involved in cardiac muscle cell development uc008pxo.1 uc008pxo.2 uc008pxo.3 uc008pxo.4 
ENSMUST00000081851.4 Tmeff2 ENSMUST00000081851.4 transmembrane protein with EGF-like and two follistatin-like domains 2 (from RefSeq NM_019790.4) ENSMUST00000081851.1 ENSMUST00000081851.2 ENSMUST00000081851.3 MNCb-1026 NM_019790 Q3UY20 Q8CDH1 Q9JJE3 Q9QYM9 TEFF2_MOUSE uc007axj.1 uc007axj.2 uc007axj.3 May be a survival factor for hippocampal and mesencephalic neurons. The shedded form may up-regulate cell proliferation (By similarity). Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QYM9-1; Sequence=Displayed; Name=2; IsoId=Q9QYM9-2; Sequence=VSP_014314; Widely expressed in the brain. In the olfactory bulb expressed in mitral cell, granule, and glomerular layers. In the hippocampus expressed in hippocampal cornu ammonis, pyramidal layer, dentate gyrus, and substantia nigra pars compacta. First detected at 11 dpc, reaches a maximum at 15 dpc, and remains constant through 17 dpc. O-glycosylated; contains chondroitin sulfate glycosaminoglycans. A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by a metalloproteinase ADAM (By similarity). Belongs to the tomoregulin family. Sequence=BAA95049.1; Type=Frameshift; Evidence=; basement membrane plasma membrane neuromuscular junction development motor neuron axon guidance animal organ morphogenesis tissue development membrane integral component of membrane dendrite development negative regulation of cell migration receptor clustering wound healing, spreading of cells negative regulation of integrin biosynthetic process negative regulation of stress fiber assembly uc007axj.1 uc007axj.2 uc007axj.3 
ENSMUST00000081857.14 Myh6 ENSMUST00000081857.14 myosin, heavy polypeptide 6, cardiac muscle, alpha, transcript variant 1 (from RefSeq NM_001164171.1) ENSMUST00000081857.1 ENSMUST00000081857.10 ENSMUST00000081857.11 ENSMUST00000081857.12 ENSMUST00000081857.13 ENSMUST00000081857.2 ENSMUST00000081857.3 ENSMUST00000081857.4 ENSMUST00000081857.5 ENSMUST00000081857.6 ENSMUST00000081857.7 ENSMUST00000081857.8 ENSMUST00000081857.9 MYH6_MOUSE Myhca NM_001164171 Q02566 Q64258 Q64738 uc007txs.1 uc007txs.2 uc007txs.3 uc007txs.4 Muscle contraction. Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Q02566; O70468: Mybpc3; NbExp=5; IntAct=EBI-299157, EBI-8347074; Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents a conventional myosin. This protein should not be confused with the unconventional myosin-6 (MYO6). microfilament motor activity nucleotide binding in utero embryonic development stress fiber regulation of the force of heart contraction regulation of heart rate motor activity actin binding protein binding calmodulin binding ATP binding cytoplasm mitochondrion muscle myosin complex muscle contraction striated muscle contraction adult heart development visceral muscle development regulation of heart contraction regulation of blood pressure cardiac muscle hypertrophy in response to stress myosin complex ATPase activity protein kinase binding myofibril Z disc actin filament-based movement muscle filament sliding myofibril assembly actin-dependent ATPase activity calcium-dependent ATPase activity myosin filament identical protein binding protein homodimerization activity regulation of ATPase activity sarcomere organization ATP metabolic process protein heterodimerization activity cardiac muscle fiber development actin filament binding atrial cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue morphogenesis cardiac muscle contraction regulation of heart growth uc007txs.1 uc007txs.2 uc007txs.3 uc007txs.4 
ENSMUST00000081869.7 Tor4a ENSMUST00000081869.7 torsin family 4, member A (from RefSeq NM_146115.4) ENSMUST00000081869.1 ENSMUST00000081869.2 ENSMUST00000081869.3 ENSMUST00000081869.4 ENSMUST00000081869.5 ENSMUST00000081869.6 NM_146115 Q8BH02 Q921D7 TOR4A_MOUSE uc008iql.1 uc008iql.2 uc008iql.3 uc008iql.4 Membrane ; Single-pass membrane protein Belongs to the ClpA/ClpB family. Torsin subfamily. Sequence=AAH13092.1; Type=Frameshift; Evidence=; nucleotide binding ATP binding nuclear envelope endoplasmic reticulum lumen biological_process membrane integral component of membrane ATPase activity uc008iql.1 uc008iql.2 uc008iql.3 uc008iql.4 
ENSMUST00000081872.13 Nell1 ENSMUST00000081872.13 NEL-like 1 (from RefSeq NM_001037906.2) ENSMUST00000081872.1 ENSMUST00000081872.10 ENSMUST00000081872.11 ENSMUST00000081872.12 ENSMUST00000081872.2 ENSMUST00000081872.3 ENSMUST00000081872.4 ENSMUST00000081872.5 ENSMUST00000081872.6 ENSMUST00000081872.7 ENSMUST00000081872.8 ENSMUST00000081872.9 NELL1_MOUSE NM_001037906 Q2VWQ2 uc009hby.1 uc009hby.2 uc009hby.3 Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. Homotrimer (By similarity). Binds to PKC beta-1 (By similarity). Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization (By similarity). Interacts with ROBO3 (PubMed:26586761). Cytoplasm Nucleus envelope Secreted Note=Colocalizes with ATRAID on the nuclear envelope and the perinuclear region. It has been demonstrated that ROBO3 binds to both NELL1 and NELL2. However, NELL1 is not expressed in the spinal cord at the time of commissural axon growth to the midline and has no significant effect on commissural axon repulsion in vitro, suggesting that NELL1 is not a functional ligand for ROBO3 in commissural axons. It remains possible, however, that NELL1 functions as a ligand for ROBO3 at another spatiotemporal location. protein kinase C binding calcium ion binding extracellular region extracellular space nucleus nuclear envelope cytoplasm heparin binding regulation of gene expression cell differentiation positive regulation of bone mineralization negative regulation of osteoblast proliferation identical protein binding positive regulation of apoptotic process regulation of osteoblast differentiation positive regulation of osteoblast differentiation positive regulation of ossification perinuclear region of cytoplasm protein homotrimerization negative regulation of cellular protein catabolic process uc009hby.1 uc009hby.2 uc009hby.3 
ENSMUST00000081880.7 Lamp3 ENSMUST00000081880.7 lysosomal-associated membrane protein 3 (from RefSeq NM_177356.3) ENSMUST00000081880.1 ENSMUST00000081880.2 ENSMUST00000081880.3 ENSMUST00000081880.4 ENSMUST00000081880.5 ENSMUST00000081880.6 LAMP3_MOUSE NM_177356 Q7TST5 Q8C1F6 uc007ypb.1 uc007ypb.2 uc007ypb.3 Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity. Monomer. Interacts with FURIN. Cell surface Lysosome membrane ; Single-pass type I membrane protein Cytoplasmic vesicle membrane ; Single-pass type I membrane protein Early endosome membrane ; Single-pass type I membrane protein Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells. Belongs to the LAMP family. adaptive immune response immune system process molecular_function lysosome lysosomal membrane early endosome plasma membrane regulation of autophagy positive regulation of gene expression membrane integral component of membrane cytoplasmic vesicle membrane cytoplasmic vesicle late endosome membrane vesicle response to interferon-alpha negative regulation of cysteine-type endopeptidase activity involved in apoptotic process intracellular membrane-bounded organelle perinuclear region of cytoplasm establishment of protein localization to organelle alveolar lamellar body membrane negative regulation of proteasomal protein catabolic process regulation of viral life cycle uc007ypb.1 uc007ypb.2 uc007ypb.3 
ENSMUST00000081893.7 Syn1 ENSMUST00000081893.7 synapsin I, transcript variant a (from RefSeq NM_013680.4) ENSMUST00000081893.1 ENSMUST00000081893.2 ENSMUST00000081893.3 ENSMUST00000081893.4 ENSMUST00000081893.5 ENSMUST00000081893.6 NM_013680 O88935 Q62279 Q8QZT8 SYN1_MOUSE Syn-1 uc009stw.1 uc009stw.2 uc009stw.3 uc009stw.4 Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (By similarity). Also involved in the regulation of axon outgrowth and synaptogenesis (PubMed:7568107). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric- oxide functions at a presynaptic level (By similarity). Homodimer (By similarity). Can form oligomers with SYN2 (By similarity). Interacts with CAPON (By similarity). Forms a ternary complex with NOS1 (By similarity). Isoform Ib interacts with PRNP (PubMed:11571277). Synapse Golgi apparatus Presynapse Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Note=Dissociates from synaptic vesicles and redistributes into the axon during action potential firing, in a step that precedes fusion of vesicles with the plasma membrane. Reclusters to presynapses after the cessation of synaptic activity. Event=Alternative splicing; Named isoforms=3; Name=Ia; IsoId=O88935-2; Sequence=Displayed; Name=Ib; IsoId=O88935-1; Sequence=VSP_015206, VSP_015207; Name=3; IsoId=O88935-3; Sequence=VSP_015205; The A region binds phospholipids with a preference for negatively charged species. Substrate of different protein kinases. Phosphorylation, including phosphorylation at Ser-9, promotes synapsin-1 dissociation from synaptic vesicles, regulates its rate of dispersion, and controls the kinetics of vesicle pool turnover. Belongs to the synapsin family. synaptonemal complex actin binding protein binding ATP binding Golgi apparatus cytosol cytoskeleton neurotransmitter secretion synaptic vesicle postsynaptic density protein kinase binding cell junction axon dendrite synaptic vesicle membrane identical protein binding myelin sheath intracellular organelle synapse regulation of short-term neuronal synaptic plasticity calcium-dependent protein binding neuron development presynaptic active zone synapse organization synaptic vesicle clustering presynapse extrinsic component of synaptic vesicle membrane anchored component of synaptic vesicle membrane synaptic vesicle cycle uc009stw.1 uc009stw.2 uc009stw.3 uc009stw.4 
ENSMUST00000081896.5 4930512M02Rik ENSMUST00000081896.5 RIKEN cDNA 4930512M02 gene (from RefSeq NM_001305143.1) 4930512M02Rik ENSMUST00000081896.1 ENSMUST00000081896.2 ENSMUST00000081896.3 ENSMUST00000081896.4 NM_001305143 Q5SQK8 Q5SQK8_MOUSE uc007iah.1 uc007iah.2 uc007iah.3 uc007iah.4 molecular_function cellular_component biological_process membrane integral component of membrane uc007iah.1 uc007iah.2 uc007iah.3 uc007iah.4 
ENSMUST00000081904.7 Dysf ENSMUST00000081904.7 dysferlin, transcript variant 1 (from RefSeq NM_021469.4) DYSF_MOUSE ENSMUST00000081904.1 ENSMUST00000081904.2 ENSMUST00000081904.3 ENSMUST00000081904.4 ENSMUST00000081904.5 ENSMUST00000081904.6 Fer1l1 NM_021469 Q6KAR3 Q80VT0 Q9ESD7 Q9QXC0 uc009cot.1 uc009cot.2 uc009cot.3 uc009cot.4 Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with CAV3. Interacts with AHNAK; the interaction is direct and Ca(2+)-independent. Interacts with AHNAK2; the interaction is direct and Ca(2+)-independent (By similarity). Interacts with ANXA1; the interaction is Ca(2+)- and injury state-dependent. Interacts with ANXA2; the interaction is Ca(2+)- and injury state-dependent. Interacts with CACNA1S and PARVB. Interacts with TRIM72/MG53; interaction is required for transport to sites of cell injury during repair patch formation. Interacts with RIPOR2; this interaction occurs during early myogenic differentiation (By similarity). Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Cell membrane Note=Colocalizes, during muscle differentiation, with BIN1 in the T-tubule system of myotubules and at the site of contact between two myotubes or a myoblast and a myotube (By similarity). Accumulates and colocalizes with fusion vesicles at the sarcolemma disruption sites. Wounding of myotubes led to its focal enrichment to the site of injury and to its relocalization in a Ca(2+)-dependent manner toward the plasma membrane (By similarity). Colocalizes with ANXA1 and ANXA2 at the sarcolemma in skeletal muscle. Colocalizes with PARVB at the sarcolemma of skeletal muscle (By similarity). Retained by caveolin at the plasmma membrane. Reaches the plasmma membrane through a caveolin-independent mechanism. Colocalizes, during muscle differentiation, with CACNA1S in the T- tubule system of myotubules. Detected on the apical plasma membrane of the syncytiotrophoblast (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9ESD7-1; Sequence=Displayed; Name=2; IsoId=Q9ESD7-2; Sequence=VSP_035930, VSP_035931, VSP_035932, VSP_035933; Name=3; IsoId=Q9ESD7-3; Sequence=VSP_035930, VSP_035932, VSP_035933; Expressed in skeletal and cardiac muscles (at protein level). Expressed in skeletal muscle and heart. Also found in brain, liver and kidney. All seven C2 domains associate with lipid membranes in a calcium-dependent manner. Domains C2 1 and 3 have the highest affinity for calcium, the C2 domain 1 seems to be largely unstructured in the absence of bound ligands (By similarity). Note=Defects in Dysf are the cause of a slowly progressive muscular dystrophy observed in SJL mice. It affects primarily the proximal muscles and it is inherited as autosomal recessive trait. Mice lacking Dysf maintain a functional dystrophin glycoprotein complex (DGC) but their muscle cells are defective in repairing the plasma membrane disruptions and accumulates vesicles at the sarcolemma. They develop a progressive muscular dystrophy and cardiomyopathy. Belongs to the ferlin family. Sequence=BAD21394.1; Type=Erroneous initiation; Evidence=; Sequence=CAB63111.1; Type=Miscellaneous discrepancy; Note=The sequence differs significantly from amino acid position 1855.; Evidence=; angiogenesis plasma membrane repair positive regulation of endothelial cell proliferation monocyte activation involved in immune response macrophage activation involved in immune response calcium ion binding protein binding phospholipid binding calcium-dependent phospholipid binding nucleus cytoplasm endosome early endosome late endosome Golgi apparatus microtubule organizing center microtubule plasma membrane glycerol metabolic process vesicle fusion microtubule binding lipid binding negative regulation of gene expression membrane integral component of membrane lipid storage lamellipodium endocytic vesicle T-tubule cytoplasmic vesicle membrane cytoplasmic vesicle T-tubule organization negative regulation of protein catabolic process sarcolemma alpha-tubulin binding skeletal muscle tissue regeneration fat cell differentiation positive regulation of cell adhesion metal ion binding muscle fiber development cytokine secretion negative regulation of phagocytosis cellular response to osmotic stress positive regulation of neutrophil chemotaxis regulation of calcium ion import membrane microdomain negative regulation of high voltage-gated calcium channel activity negative regulation of protein polyubiquitination uc009cot.1 uc009cot.2 uc009cot.3 uc009cot.4 
ENSMUST00000081907.8 Ceacam5 ENSMUST00000081907.8 CEA cell adhesion molecule 5 (from RefSeq NM_028480.2) CEAM5_MOUSE ENSMUST00000081907.1 ENSMUST00000081907.2 ENSMUST00000081907.3 ENSMUST00000081907.4 ENSMUST00000081907.5 ENSMUST00000081907.6 ENSMUST00000081907.7 NM_028480 Psg30 Q3UKK2 uc009fiz.1 uc009fiz.2 uc009fiz.3 Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Homodimer. Cell membrane ; Lipid-anchor, GPI-anchor Apical cell membrane Cell surface Note=Localized to the apical glycocalyx surface. Belongs to the immunoglobulin superfamily. CEA family. molecular_function cellular_component plasma membrane apoptotic process cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules biological_process cell surface membrane apical plasma membrane anchored component of membrane identical protein binding uc009fiz.1 uc009fiz.2 uc009fiz.3 
ENSMUST00000081908.8 Rpl10l ENSMUST00000081908.8 ribosomal protein L10-like (from RefSeq NM_001162933.1) ENSMUST00000081908.1 ENSMUST00000081908.2 ENSMUST00000081908.3 ENSMUST00000081908.4 ENSMUST00000081908.5 ENSMUST00000081908.6 ENSMUST00000081908.7 NM_001162933 P86048 RL10L_MOUSE Rpl10l uc011ymh.1 uc011ymh.2 Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I (PubMed:28502657). Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis (PubMed:28502657). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28502657). The male germ cell-specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome (PubMed:36517592). It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm (PubMed:36517592). Component of a male germ cell-specific 60S large ribosomal subunit (LSU), which contains RPL10L and RPL39L, instead of RPL10 and RPL39 paralogs (PubMed:28502657, PubMed:36517592). The composition of the rest of the complex is similar to classical ribosomes (PubMed:36517592). Cytoplasm Testis-specific. Spermatogenic failure and male infertility (PubMed:28502657). Spermatocytes show defects in the transition from prophase to metaphase of meiosis I due to impaired ribosome biogenesis in late prophase spermatocytes (PubMed:28502657). Belongs to the universal ribosomal protein uL16 family. ribosomal large subunit assembly structural constituent of ribosome nucleus endoplasmic reticulum cytosol ribosome polysome translation spermatogenesis cytosolic large ribosomal subunit uc011ymh.1 uc011ymh.2 
ENSMUST00000081926.13 Zfp341 ENSMUST00000081926.13 zinc finger protein 341 (from RefSeq NM_199304.1) ENSMUST00000081926.1 ENSMUST00000081926.10 ENSMUST00000081926.11 ENSMUST00000081926.12 ENSMUST00000081926.2 ENSMUST00000081926.3 ENSMUST00000081926.4 ENSMUST00000081926.5 ENSMUST00000081926.6 ENSMUST00000081926.7 ENSMUST00000081926.8 ENSMUST00000081926.9 NM_199304 Q6PGC9 Q6PGC9_MOUSE Zfp341 uc008njo.1 uc008njo.2 uc008njo.3 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding molecular_function nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding cellular_component nucleus regulation of transcription, DNA-templated biological_process positive regulation of transcription, DNA-templated uc008njo.1 uc008njo.2 uc008njo.3 
ENSMUST00000081927.4 Serpinb9g ENSMUST00000081927.4 serine (or cysteine) peptidase inhibitor, clade B, member 9g (from RefSeq NM_011455.3) ENSMUST00000081927.1 ENSMUST00000081927.2 ENSMUST00000081927.3 NM_011455 Q8VHQ1 Q8VHQ1_MOUSE Serpinb9g uc007qah.1 uc007qah.2 uc007qah.3 uc007qah.4 uc007qah.5 Belongs to the serpin family. Ov-serpin subfamily. serine-type endopeptidase inhibitor activity extracellular space cytoplasm negative regulation of endopeptidase activity uc007qah.1 uc007qah.2 uc007qah.3 uc007qah.4 uc007qah.5 
ENSMUST00000081933.14 Dtx3l ENSMUST00000081933.14 deltex 3-like, E3 ubiquitin ligase (from RefSeq NM_001013371.2) Bbap DTX3L_MOUSE ENSMUST00000081933.1 ENSMUST00000081933.10 ENSMUST00000081933.11 ENSMUST00000081933.12 ENSMUST00000081933.13 ENSMUST00000081933.2 ENSMUST00000081933.3 ENSMUST00000081933.4 ENSMUST00000081933.5 ENSMUST00000081933.6 ENSMUST00000081933.7 ENSMUST00000081933.8 ENSMUST00000081933.9 NM_001013371 Q3UIR3 Q8BN11 uc007zbv.1 uc007zbv.2 uc007zbv.3 E3 ubiquitin-protein ligase which, in association with ADP- ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses. Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4. In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon- stimulated gene transcription and thus STAT1-mediated control of viral replication. Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM. In addition, required for the recruitment of HGS and STAM to early endosomes. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Binding to PARP9 enhances DTX3L catalytic activity. Protein modification; protein ubiquitination. Homodimer and heterodimer. Can heterodimerize with DTX1, enhancing its ubiquitin ligase activity in vitro. Interacts (via N- terminus) with ADP ribosyltransferase PARP9/BAL1 (via PARP catalytic domain) forming a stable complex; the interaction is required to activate PARP9 but is dispensable for DTX3L catalytic activity. Forms a complex with STAT1 and PARP9 independently of IFNB1 or IFNG-mediated STAT1 'Tyr-701' phosphorylation. Found in a complex with PARP9, STAT1 and H2BC9. Found in a complex with E3 ligase ITCH and ESCRT-0 components HGS and STAM. Interacts (via C-terminus) with ITCH; the interaction is increased upon CXCL12 stimulation and inhibits ITCH catalytic activity; the interaction is direct. Interacts with HGS and STAM; the interaction brings together HGS and STAM and promotes their recruitment to early endosomes. Cytoplasm Nucleus Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Translocates to the nucleus in response to IFNG or IFNB1 stimulation. Localizes at sites of DNA damage in a PARP1-dependent manner. Localization to early endosomes is increased upon CXCL12 stimulation where it co-localizes with ITCH, CXCL4, HGS and STAM. A minor proportion localizes to lysosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UIR3-1; Sequence=Displayed; Name=2; IsoId=Q3UIR3-2; Sequence=VSP_038533; Developmentally regulated. Expressed prominently in the thymus and specific regions of the brain, and more weakly expressed in the gut. In adults, highly expressed in the thymus and intestine. Autoubiquitinated. Belongs to the Deltex family. Sequence=BAC41115.1; Type=Frameshift; Evidence=; positive regulation of defense response to virus by host immune system process ubiquitin-protein transferase activity enzyme inhibitor activity nucleus nucleoplasm cytoplasm lysosome lysosomal membrane endosome early endosome cytosol DNA repair double-strand break repair chromatin organization ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus Notch signaling pathway enzyme activator activity endosome to lysosome transport histone monoubiquitination protein transport membrane protein ubiquitination transferase activity enzyme binding early endosome membrane positive regulation of protein binding macromolecular complex histone H2A ubiquitination histone H2B ubiquitination positive regulation of chromatin binding histone binding ubiquitin-like protein ligase binding innate immune response positive regulation of transcription, DNA-templated metal ion binding negative regulation of ubiquitin-protein transferase activity defense response to virus protein autoubiquitination protein K48-linked ubiquitination STAT family protein binding positive regulation of protein localization to nucleus positive regulation of NAD+ ADP-ribosyltransferase activity positive regulation of protein localization to early endosome positive regulation of receptor catabolic process positive regulation of double-strand break repair via nonhomologous end joining uc007zbv.1 uc007zbv.2 uc007zbv.3 
ENSMUST00000081945.5 Krt87 ENSMUST00000081945.5 keratin 87 (from RefSeq NM_001003668.2) B2RTF5 ENSMUST00000081945.1 ENSMUST00000081945.2 ENSMUST00000081945.3 ENSMUST00000081945.4 KRT87_MOUSE Kb25 Krt2-25 Krt83 Krt87 NM_001003668 Q6IMF0 uc007xte.1 uc007xte.2 uc007xte.3 uc007xte.4 Heterotetramer of two type I and two type II keratins. There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). Belongs to the intermediate filament family. molecular_function intermediate filament biological_process keratin filament uc007xte.1 uc007xte.2 uc007xte.3 uc007xte.4 
ENSMUST00000081946.5 Timm50 ENSMUST00000081946.5 translocase of inner mitochondrial membrane 50, transcript variant 2 (from RefSeq NR_183621.1) ENSMUST00000081946.1 ENSMUST00000081946.2 ENSMUST00000081946.3 ENSMUST00000081946.4 NR_183621 Q8R3A7 Q91Z17 Q9D880 TIM50_MOUSE Tim50 uc009fyg.1 uc009fyg.2 uc009fyg.3 Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM23. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15. Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the TIM50 family. Sequence=AAH10303.1; Type=Erroneous initiation; Evidence=; release of cytochrome c from mitochondria phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity interleukin-2 receptor binding nucleoplasm mitochondrion mitochondrial inner membrane mitochondrial inner membrane presequence translocase complex protein dephosphorylation mitochondrial membrane organization protein transport membrane integral component of membrane nuclear speck protein import into mitochondrial matrix peptidyl-tyrosine dephosphorylation ribonucleoprotein complex binding uc009fyg.1 uc009fyg.2 uc009fyg.3 
ENSMUST00000081960.5 Or10ak7 ENSMUST00000081960.5 olfactory receptor family 10 subfamily AK member 7 (from RefSeq NM_146399.2) B1ARV2 B1ARV2_MOUSE ENSMUST00000081960.1 ENSMUST00000081960.2 ENSMUST00000081960.3 ENSMUST00000081960.4 NM_146399 Olfr1328 Or10ak7 uc290pjb.1 uc290pjb.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC106978.2, BC148290.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc290pjb.1 uc290pjb.2 
ENSMUST00000081964.7 Hopx ENSMUST00000081964.7 HOP homeobox, transcript variant 1 (from RefSeq NM_175606.3) ENSMUST00000081964.1 ENSMUST00000081964.2 ENSMUST00000081964.3 ENSMUST00000081964.4 ENSMUST00000081964.5 ENSMUST00000081964.6 HOP_MOUSE Hod Hop NM_175606 Ob1 Q8C1N5 Q8CJ22 Q8R1H0 uc008xvw.1 uc008xvw.2 uc008xvw.3 uc008xvw.4 Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (PubMed:12297045, PubMed:12297046). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (By similarity). Interacts with serum response factor (SRF) (PubMed:12297045, PubMed:12297046). Component of a large complex containing histone deacetylases such as HDAC2 (PubMed:12975471). Interacts with the acetylated forms of HSPA1A and HSPA1B. Interacts with HSPA8 (By similarity). Q8R1H0; P97471: Smad4; NbExp=2; IntAct=EBI-6913924, EBI-5259270; Nucleus Cytoplasm Note=According to PubMed:14516659 it is cytoplasmic. Expressed in the embryonic and adult heart and in the adult brain, liver, lung, skeletal muscle, intestine and spleen. Throughout embryonic and postnatal development, it is expressed in the myocardium. First detected at 7.75 dpc in trophoblasts within extraembryonic membranes, in the lateral wings of the cardiac crescent and in the anterior head folds. At 8.0 dpc, it is expressed along the length of the linear heart tube and in the head folds. Expressed throughout the myocardium at 9.5 dpc and in the branchial arches. At 12.5 dpc, it is expressed in the heart and in the ventricular zone of the neural tube. At 13.5 dpc, it is weakly expressed in the intestinal epithelium. At 13.5 dpc and 15.5 dpc, it is also expressed in skeletal muscle, stratified epithelium (upper aerodigestive tract and skin), epithelium of developing airways, vibrissae, midbrain/hindbrain junction, meninges, mesenchymal cellular condensations that preceded cartilage formation and chondrocytes. By the transcription factor NKX2-5 that acts as a direct regulator. Mice display partial embryonic lethality and heart failure. negative regulation of transcription from RNA polymerase II promoter trophectodermal cell differentiation DNA binding protein binding nucleus cytoplasm multicellular organism development heart development regulation of heart contraction histone deacetylation cell differentiation regulation of protein binding positive regulation of skeletal muscle tissue regeneration negative regulation of cell differentiation lung alveolus development chaperone-mediated protein complex assembly positive regulation of striated muscle cell differentiation uc008xvw.1 uc008xvw.2 uc008xvw.3 uc008xvw.4 
ENSMUST00000081966.5 Odf1 ENSMUST00000081966.5 outer dense fiber of sperm tails 1 (from RefSeq NM_008757.3) A6H656 A6H656_MOUSE ENSMUST00000081966.1 ENSMUST00000081966.2 ENSMUST00000081966.3 ENSMUST00000081966.4 NM_008757 Odf1 uc011zsh.1 uc011zsh.2 Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. outer dense fiber protein domain specific binding uc011zsh.1 uc011zsh.2 
ENSMUST00000081978.10 Slc39a8 ENSMUST00000081978.10 solute carrier family 39 (metal ion transporter), member 8, transcript variant 3 (from RefSeq NM_026228.5) ENSMUST00000081978.1 ENSMUST00000081978.2 ENSMUST00000081978.3 ENSMUST00000081978.4 ENSMUST00000081978.5 ENSMUST00000081978.6 ENSMUST00000081978.7 ENSMUST00000081978.8 ENSMUST00000081978.9 NM_026228 Q8BTQ3 Q8BUD6 Q91W10 Q9D426 Q9D5V4 S39A8_MOUSE Slc39a8 Zip8 uc008rlz.1 uc008rlz.2 uc008rlz.3 uc008rlz.4 uc008rlz.5 Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity (PubMed:16638970, PubMed:18037372, PubMed:22563477, PubMed:29337306). Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion (PubMed:16638970, PubMed:18037372, PubMed:22563477, PubMed:27166256). Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:27166256). Also imports cadmium a non- essential metal which is cytotoxic and carcinogenic (PubMed:15722412, PubMed:16638970, PubMed:17108009, PubMed:18037372, PubMed:24529376). May also transport iron and cobalt through membranes (PubMed:16638970, PubMed:22898811, PubMed:24529376). Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development (PubMed:24529376, PubMed:29337306). Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PubMed:29927450). Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes (PubMed:23403290). Protects, for instance, cells from injury and death at the onset of inflammation (By similarity). By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (PubMed:30015240). Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient (PubMed:28481222). Also participates in manganese reabsorption in the proximal tubule of the kidney (By similarity). By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain. With manganese cellular uptake also participates in mitochondrial proper function (By similarity). Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR- mediated T cell activation (By similarity). Reaction=2 hydrogencarbonate(out) + Zn(2+)(out) = 2 hydrogencarbonate(in) + Zn(2+)(in); Xref=Rhea:RHEA:62252, ChEBI:CHEBI:17544, ChEBI:CHEBI:29105; Evidence=; Reaction=hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) = hydrogencarbonate(in) + selenite(in) + Zn(2+)(in); Xref=Rhea:RHEA:62264, ChEBI:CHEBI:17544, ChEBI:CHEBI:18212, ChEBI:CHEBI:29105; Evidence=; Reaction=2 hydrogencarbonate(out) + Mn(2+)(out) = 2 hydrogencarbonate(in) + Mn(2+)(in); Xref=Rhea:RHEA:62260, ChEBI:CHEBI:17544, ChEBI:CHEBI:29035; Evidence=; Reaction=Cd(2+)(out) + 2 hydrogencarbonate(out) = Cd(2+)(in) + 2 hydrogencarbonate(in); Xref=Rhea:RHEA:62256, ChEBI:CHEBI:17544, ChEBI:CHEBI:48775; Evidence=; Reaction=Fe(2+)(out) + 2 hydrogencarbonate(out) = Fe(2+)(in) + 2 hydrogencarbonate(in); Xref=Rhea:RHEA:62368, ChEBI:CHEBI:17544, ChEBI:CHEBI:29033; Evidence=; Reaction=Co(2+)(out) + 2 hydrogencarbonate(out) = Co(2+)(in) + 2 hydrogencarbonate(in); Xref=Rhea:RHEA:73491, ChEBI:CHEBI:17544, ChEBI:CHEBI:48828; Evidence=; Kinetic parameters: KM=0.84 uM for Cd(2+) ; KM=0.62 uM for Cd(2+) ; KM=0.48 uM for Cd(2+) (measured in xenopus oocytes) ; KM=0.26 uM for Zn(2+) (measured in xenopus oocytes) ; KM=2.2 uM for Mn(2+) ; KM=5.9 uM for selenite/HSeO3(-) ; Vmax=204 pmol/min/mg enzyme for the uptake of Cd(2+) ; Vmax=92 pmol/min/mg enzyme for the uptake of Cd(2+) ; Vmax=73.8 pmol/min/mg enzyme for the uptake of Mn(2+) ; pH dependence: Optimum pH is 7.5. ; Homodimer. Cell membrane ulti-pass membrane protein Apical cell membrane ulti-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Note=Localizes to the lysosome of activated T-cells. A large fraction of the protein is found intracellularly in microvascular capillary endothelial cells that constitute the blood-brain barrier. Localized and functional at both apical and basolateral membranes of microvascular capillary endothelial cells that constitute the blood-brain barrier. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91W10-1; Sequence=Displayed; Name=2; IsoId=Q91W10-2; Sequence=VSP_029886, VSP_029887; Ubiquitously expressed. Expressed in the developing heart by cardiac endothelial cells with a peak of expression at 12.5 dpc and a decline to low levels in adult heart. Up-regulated in monocytes upon adhesion and recruitment to arteries (PubMed:30015240). Up-regulated by the pro-inflammatory cytokine interleukin-1 beta/IL1B (PubMed:24529376). N-glycosylated (PubMed:16638970). N-glycosylation is not required for proper iron and zinc transport (By similarity). The homozygous knockout of Slc39a8 is embryonic lethal by 16.5 dpc. Hearts exhibit hypertrabeculation and non- compaction phenotypes including excessive trabeculae and thin compact myocardium. These phenotypes are evident at 12.5 dpc and prominent at 14.5 dpc, and embryos that survive until 16.5 dpc display an even stronger phenotype. Ventricular septal defects are also observed. Some 14.5 dpc embryos exhibit body edema, suggesting that cardiac muscle function is compromised. Hearts display increased cardiomyocyte proliferation (PubMed:29337306). This is associated with decreased expression of metalloproteases and impaired degradation of the extracellular matrix leading to its aberrant accumulation in heart (PubMed:29337306). In mice homozygous for an hypomorphic allele of the gene, resulting in significant decreased expression of the protein, hematopoiesis and the development of multiple organs are affected from very early embryogenesis (PubMed:22563477). Conditional knockout of the gene at the level of the whole organism decreases manganese levels in tissues but has no effect on zinc and iron (PubMed:28481222). Conditional liver-specific knockout of the gene results in decreased systemic tissue manganese levels coupled to increased manganese in bile but has no effect on zinc or iron levels (PubMed:28481222). The decreased expression of the channel in testis vascular endothelial cells confers the resistance to cadmium-induced testicular damage trait to some mice strains. Belongs to the ZIP transporter (TC 2.A.5) family. zinc ion transmembrane transporter activity plasma membrane integral component of plasma membrane ion transport zinc II ion transport cellular zinc ion homeostasis membrane integral component of membrane metal ion transport organelle membrane metal ion transmembrane transporter activity transmembrane transport cadmium ion transmembrane transport zinc II ion transmembrane import uc008rlz.1 uc008rlz.2 uc008rlz.3 uc008rlz.4 uc008rlz.5 
ENSMUST00000081980.7 Med9 ENSMUST00000081980.7 mediator complex subunit 9 (from RefSeq NM_138675.3) ENSMUST00000081980.1 ENSMUST00000081980.2 ENSMUST00000081980.3 ENSMUST00000081980.4 ENSMUST00000081980.5 ENSMUST00000081980.6 MED9_MOUSE Med25 NM_138675 Q8BHQ8 Q8R5H4 Q8VCS6 uc007jfg.1 uc007jfg.2 uc007jfg.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Nucleus Belongs to the Mediator complex subunit 9 family. transcription cofactor activity protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter biological_process mediator complex uc007jfg.1 uc007jfg.2 uc007jfg.3 
ENSMUST00000081982.12 Dzank1 ENSMUST00000081982.12 double zinc ribbon and ankyrin repeat domains 1, transcript variant 1 (from RefSeq NM_172859.3) A2AN93 DZAN1_MOUSE ENSMUST00000081982.1 ENSMUST00000081982.10 ENSMUST00000081982.11 ENSMUST00000081982.2 ENSMUST00000081982.3 ENSMUST00000081982.4 ENSMUST00000081982.5 ENSMUST00000081982.6 ENSMUST00000081982.7 ENSMUST00000081982.8 ENSMUST00000081982.9 NM_172859 Q8C008 Q8C060 uc008mrd.1 uc008mrd.2 uc008mrd.3 Involved in vesicle transport in photoreceptor cells. Interacts with NINL. Associates with DYNC1H1 and multiple dynein intermediate and light chains as well as actin-binding proteins. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body Note=Colocalizes with NINL at the base of cilia. Sequence=BAC27747.1; Type=Frameshift; Evidence=; Sequence=BAC27960.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence=; molecular_function cellular_component metal ion binding uc008mrd.1 uc008mrd.2 uc008mrd.3 
ENSMUST00000081985.2 Or8b38 ENSMUST00000081985.2 olfactory receptor family 8 subfamily B member 38 (from RefSeq NM_001011739.1) ENSMUST00000081985.1 NM_001011739 Olfr885 Or8b38 Q7TRE0 Q7TRE0_MOUSE uc009ovu.1 uc009ovu.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ovu.1 uc009ovu.2 
ENSMUST00000081989.8 Rnf217 ENSMUST00000081989.8 ring finger protein 217 (from RefSeq NM_001146349.1) D3YYI7 ENSMUST00000081989.1 ENSMUST00000081989.2 ENSMUST00000081989.3 ENSMUST00000081989.4 ENSMUST00000081989.5 ENSMUST00000081989.6 ENSMUST00000081989.7 Ibrdc1 NM_001146349 RN217_MOUSE uc007etu.1 uc007etu.2 uc007etu.3 uc007etu.4 E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis. Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence=; Protein modification; protein ubiquitination. Interacts with HAX1. Membrane ; Single-pass membrane protein Cytoplasm Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT- type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain. Macrophage-specific knockout mice have increased iron export and altered ferroportin/SLC40A1 degradation. Belongs to the RBR family. RNF217 subfamily. ubiquitin ligase complex protein polyubiquitination ubiquitin-protein transferase activity cytoplasm ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination transferase activity ubiquitin conjugating enzyme binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity uc007etu.1 uc007etu.2 uc007etu.3 uc007etu.4 
ENSMUST00000082014.2 Tas2r110 ENSMUST00000082014.2 taste receptor, type 2, member 110 (from RefSeq NM_199155.2) ENSMUST00000082014.1 NM_199155 Q71QD1 Q7M712 TR110_MOUSE Tas2r110 uc009ejs.1 uc009ejs.2 Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). Membrane ; Multi-pass membrane protein Several bitter taste receptors with distinct ligand specificities are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009ejs.1 uc009ejs.2 
ENSMUST00000082024.7 Pals1 ENSMUST00000082024.7 protein associated with LIN7 1, MAGUK family member (from RefSeq NM_019579.3) ENSMUST00000082024.1 ENSMUST00000082024.2 ENSMUST00000082024.3 ENSMUST00000082024.4 ENSMUST00000082024.5 ENSMUST00000082024.6 Mpp5 NM_019579 PALS1_MOUSE Pals1 Q9JLB2 uc007nzi.1 uc007nzi.2 uc007nzi.3 uc007nzi.4 uc007nzi.5 Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (PubMed:17182851, PubMed:20237282). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (PubMed:22398208). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (PubMed:20399730, PubMed:26404741). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (PubMed:20399730). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (PubMed:20237282). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (PubMed:15234345). May play a role in the T-cell receptor-mediated activation of NF-kappa-B (By similarity). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (PubMed:15677456). Required for the normal polarized localization of the vesicular marker STX4 (PubMed:20237282). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (PubMed:21145499). Heterodimer with MPP1 (By similarity). Forms a heterotrimeric complex composed of PALS1, LIN7B and PATJ; the N-terminal L27 domain of PALS1 interacts with the L27 domain of PATJ and the C-terminal L27 domain of PALS1 interacts with the L27 domain of LIN7B (By similarity). Component of a complex composed of PALS1, CRB1 and MPP4 (By similarity). Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3 (By similarity). Component of a complex composed of PALS1, CRB1 and EPB41L5 (By similarity). Within the complex, interacts (via HOOK domain) with EPB41L5 (via FERM domain), and interacts with CRB1 (via intracellular domain) (By similarity). Component of a complex composed of PALS1, MPP3 and CRB1; PALS1 acts as a bridging protein between MPP3 (via guanylate kinase-like domain) and CRB1 (PubMed:16519681). Component of a complex composed of CRB3, PALS1 and PATJ (By similarity). Interacts (via PDZ domain) with PATJ (via N- terminus) (PubMed:11927608, PubMed:12527193, PubMed:20399730). Interacts with EZR (PubMed:15677456). Interacts (via PDZ domain) with CRB1 (via C-terminal ERLI motif) (By similarity). While the PDZ domain is sufficient for interaction with CRB1, the adjacent SH3 and guanylate kinase-like domains are likely to contribute to a high affinity interaction (By similarity). Interacts with WWTR1/TAZ (via WW domain) (PubMed:21145499). Interacts with MPP7 (By similarity). Interacts (via PDZ domain) with CRB3 (via C-terminus) (PubMed:12527193). Interacts with LIN7C (PubMed:10753959). Interacts with MPDZ (PubMed:15316081). Interacts with PARD6B (PubMed:12545177, PubMed:15140881). Interacts with SC6A1 (PubMed:15234345). Interacts with CDH5; the interaction promotes PALS1 localization to cell junctions and is required for CDH5- mediated vascular lumen formation and endothelial cell (PubMed:27466317). Interacts with NPHP1 (via coiled coil and SH3 domains) (By similarity). Interacts with NPHP4 (By similarity). Interacts with CRB2 (PubMed:20399730). Golgi apparatus Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cell junction, tight junction Cell junction, adherens junction Cell projection, axon Perikaryon Apical cell membrane Note=Localized to the tight junctions of epithelial cells (PubMed:10753959, PubMed:11927608, PubMed:15140881, PubMed:15677456). Localized to the Golgi apparatus in T lymphocytes (By similarity). Localized to a subset of intracellular vesicles (PubMed:15234345). Localized to the Purkinje cell body and axon (PubMed:15234345). Localized to intercellular junctions in vascular endothelial cells (By similarity). Localized to Schmidt-Lanterman incisures, the adaxonal domain, and the inner part of paranodal loops in myelinating Schwann cells of the sciatic nerve (PubMed:20237282). Localized to apical membrane domains of the outer limiting membrane (OLM) junctions in the retina (PubMed:15558731). Colocalizes with CRB1 at the OLM, apical to the adherens junction (By similarity). Colocalizes with MPP1 in the retina at the OLM (By similarity). Colocalizes with MPP3 to the subapical region of adherens junctions in the retina OLM (By similarity). Expressed in the retinal pigment epithelium (at protein level) (PubMed:15558731, PubMed:22398208, PubMed:23893895, PubMed:26404741). Expressed in the vascular plexus of the retina (at protein level) (PubMed:27466317). In the brain, expressed in the dentate gyrus of hippocampus, striatum and cerebellum (at protein level) (PubMed:15234345, PubMed:26404741). Expressed in the sciatic nerve (at protein level) (PubMed:20237282). Expressed in the kidney nephron (at protein level) (PubMed:10753959, PubMed:15558731). Expressed in the lung, and heart (PubMed:10753959, PubMed:15558731). Expressed in placenta, brain, skeletal muscles, pancreas and liver (PubMed:10753959). Expressed in the developing sciatic nerve, with increasing expression from newborn to postnatal day 20, and decreasing expression at postnatal day 60 (P60) (at protein level) (PubMed:20237282). Expressed in the developing neural tube, optic vesicle, branchial arches and kidney at 10.5 dpc (PubMed:17920587). Expressed in the ventricular layers of the developing neural tube along the entire cranial-caudal length, including the anterior forebrain and the posterior spinal cord at 11.5 dpc (PubMed:17920587). Highly expressed in cortical progenitor cells at 12 dpc, expression decreases during neurogenesis but weak expression is still present at birth (PubMed:20399730). Expressed in the developing brain at 15.5 dpc in the upper rhombic lip, ventricular zone, and external granule layer (EGL) (at protein level) (PubMed:26657772). At birth expressed in the ventricular apical lining cells, proliferating external granule layer and Purkinje cell layer (PCL), with expression remaining abundant in the EGL and weakly evident in the PCL at P6 (at protein level) (PubMed:26657772). Expressed at P8 in the EGL, cerebellar granule neuron precursors, Bergmann glia, Pcna-positive progenitor cells in the white matter, and weakly in Pax6-positive postmitotic granule neurons (at protein level) (PubMed:26657772). Expressed weakly throughout the retina between 12.5 dpc and 14.5 dpc, becoming enriched in progenitors at the outer neuroblastic layer at 14.5 dpc (PubMed:22398208). Expressed in the retinal layer of the optic vesicle, and weakly expressed in the retinal pigment epithelium at 12.5 dpc (PubMed:17920587). Localized to the apical edge of the retina between 12.5 and 16.5 dpc (PubMed:22398208). Expressed in the internal endodermal layer and in the developing saccules of the lung at 11.5 dpc (PubMed:17920587). Expressed at the outer limiting membrane of the retina at 18.5 dpc and 3 months of age (PubMed:23001562). The L27 domain 1 functions in targeting to the tight junctions by binding to and stabilizing PATJ. The PDZ domain binds to the C-terminus of SC6A1. Conditional knockout in the retina results in mice which are viable, fertile, and morphologically normal apart from microphthalmia with severe defects in visual response (PubMed:22398208). From 13.5 days post-conception (dpc) retinas show variable morphology, including retinal folding, variable thickness and disorganization (PubMed:22398208). Postnatally the retinal lamina is thinner, and disorganized, with a shortening or absence of the inner and outer segments of photoreceptor cells (PubMed:22398208). By postnatal day 60 retinas are completely or partially devoid of the outer nuclear layers and photoreceptor layer, and feature a reduced number of photoreceptor cells, disrupted cell polarity and impaired distribution of retinal neurons (PubMed:22398208). Retinal distribution of Par3 and the Crb polarity complex proteins Crbs and Patj is disrupted (PubMed:22398208). Mature mice show aberrant proliferation and apoptosis of retinal epithelia with significantly reduced or undetectable a- and b-waves in electroretinogram-measured dark-adapted response (PubMed:22398208). Conditional knockout in cerebellum proliferating progenitors at 13.5 dpc results in mislocalization of apical polarity complex proteins such as Crb proteins, Pard3, and Prkci at 15.5 dpc (PubMed:26657772). Following cerebellum conditional knockout there is an increase in migration and premature differentiation of Pax2-positive ventricular zone cells at 17.5 dpc, resulting in a reduced number of glial cell progenitors (PubMed:26657772). Conditional knockout in cerebellum results in stunted cerebellum growth and indistinct vermis foliation at birth, there is also an evident reduction of Bergmann glia, oligodendrocyte, astrocyte and GABAergic interneuron progenitors (PubMed:26657772). Conditional knockout in cerebellum shows compromised Purkinje cell migration and formation failure of Purkinje cell plate to contain both Bergmann glia and Purkinje cells, possibly as a result of abnormal Reln-Dab1 signaling at P6 (PubMed:26657772). Conditional knockout in cerebellum results in poorly layered, smaller lobes, severe defects in fissure formation and a reduced number of cerebellar granule neurons and GABAergic interneurons from P8 to P21 (PubMed:26657772). Conditional knockout in the cortex results in mice surviving to adulthood, with lower body weight but exhibit irregular movements with disrupted stride and gait, reduced exploratory initiative, reduced locomotor behavior and swim in circles (PubMed:20399730). Reduced cortical size and disrupted morphology at 12 and 14 dpc resulting in the absence of the cortex postnatally lacking virtually all cortical neurons, additionally extreme thinning of the lateral cortex is observed (PubMed:20399730). Reduced proliferation of cortical progenitor cells and increased cell death of postmitotic neurons in the developing medial cortex and ventral zone from 10.5 dpc, additionally mislocalization and reduced abundance of Crb2 and Prkci is evident (PubMed:20399730). RNAi-mediated knockdown in the sciatic nerve results in mislocalization of Exoc4/Sec8 and Stx4 in Schwann cells and thinning and shortening of Schwann cells as a result of a reduction in the myelinated fiber diameter caused by fewer myelin turns (PubMed:20237282). Conditional knockout of both Mpp3 and Pals1 in the retina results in an increase in retinal degeneration that becomes evident at one month of age (PubMed:23893895). Belongs to the MAGUK family. nucleotide binding morphogenesis of an epithelial sheet guanylate kinase activity protein binding ATP binding cytoplasm Golgi apparatus plasma membrane adherens junction cell-cell adherens junction bicellular tight junction plasma membrane organization endomembrane system membrane integral component of membrane apical plasma membrane protein domain specific binding cell junction axon peripheral nervous system myelin maintenance myelin assembly macromolecular complex myelin sheath adaxonal region protein localization to myelin sheath abaxonal region cell projection perikaryon lateral loop Schmidt-Lanterman incisure GMP metabolic process GDP metabolic process bicellular tight junction assembly protein localization to plasma membrane establishment of epithelial cell polarity uc007nzi.1 uc007nzi.2 uc007nzi.3 uc007nzi.4 uc007nzi.5 
ENSMUST00000082048.3 Mageb5 ENSMUST00000082048.3 MAGE family member B5 (from RefSeq NM_028847.1) ENSMUST00000082048.1 ENSMUST00000082048.2 Mageb5 NM_028847 Q14AN0 Q14AN0_MOUSE uc009tsk.1 uc009tsk.2 uc009tsk.3 uc009tsk.4 molecular_function cellular_component biological_process uc009tsk.1 uc009tsk.2 uc009tsk.3 uc009tsk.4 
ENSMUST00000082054.12 Rims2 ENSMUST00000082054.12 regulating synaptic membrane exocytosis 2, transcript variant 3 (from RefSeq NM_053271.2) ENSMUST00000082054.1 ENSMUST00000082054.10 ENSMUST00000082054.11 ENSMUST00000082054.2 ENSMUST00000082054.3 ENSMUST00000082054.4 ENSMUST00000082054.5 ENSMUST00000082054.6 ENSMUST00000082054.7 ENSMUST00000082054.8 ENSMUST00000082054.9 NM_053271 Q8C433 Q8CCK2 Q9EQZ7 RIMS2_MOUSE Rab3ip2 Rim2 uc007vod.1 uc007vod.2 uc007vod.3 uc007vod.4 Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity). Interacts with TSPOAP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts via its zinc finger with the first C2 domain of UNC13A. Forms a complex consisting of UNC13A, RIMS2 and RAB3A (By similarity). Heterodimer with PCLO. Part of a ternary complex involving PCLO and EPAC2. Interacts with RAB3A and RAB3B that have been activated by GTP-binding. Interacts with RAB3C, RAB3D and RAB26. Synapse, synaptosome. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=RIM2-alpha; IsoId=Q9EQZ7-1; Sequence=Displayed; Name=2; Synonyms=RIM2-gamma; IsoId=Q9EQZ7-2; Sequence=VSP_008181, VSP_008184; Name=3; Synonyms=RIM2-beta; IsoId=Q9EQZ7-3; Sequence=VSP_008182, VSP_008183; Detected in testis, pituitary and an insulinoma cell line. Detected at low levels in cerebellar cortex. protein binding neurotransmitter transport intracellular protein transport exocytosis neurotransmitter secretion positive regulation of gene expression membrane synaptic vesicle docking synaptic vesicle priming Rab GTPase binding calcium ion regulated exocytosis regulation of exocytosis protein domain specific binding cAMP-mediated signaling cell junction insulin secretion cell differentiation macromolecular complex regulation of membrane potential presynaptic membrane neuron projection ion channel binding synapse metal ion binding protein heterodimerization activity regulation of synaptic plasticity presynaptic active zone cytoskeleton of presynaptic active zone maintenance of presynaptic active zone structure calcium ion-regulated exocytosis of neurotransmitter positive regulation of synaptic transmission inhibitory synapse spontaneous neurotransmitter secretion positive regulation of inhibitory postsynaptic potential presynaptic active zone cytoplasmic component structural constituent of presynaptic active zone glutamatergic synapse GABA-ergic synapse positive regulation of dendrite extension regulation of synaptic vesicle exocytosis positive regulation of excitatory postsynaptic potential uc007vod.1 uc007vod.2 uc007vod.3 uc007vod.4 
ENSMUST00000082059.7 Erbb3 ENSMUST00000082059.7 erb-b2 receptor tyrosine kinase 3 (from RefSeq NM_010153.2) ENSMUST00000082059.1 ENSMUST00000082059.2 ENSMUST00000082059.3 ENSMUST00000082059.4 ENSMUST00000082059.5 ENSMUST00000082059.6 ERBB3_MOUSE NM_010153 Q3KQR1 Q61526 Q68J64 Q810U8 Q8K317 uc007hnm.1 uc007hnm.2 uc007hnm.3 Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5, PA2G4, GRB7 and MUC1 (By similarity). Interacts with MYOC (PubMed:23897819). Found in a ternary complex with NRG1 and ITGAV:ITGB3 or ITGA6:ITGB4 (By similarity). Q61526; P70424: Erbb2; NbExp=2; IntAct=EBI-931878, EBI-2945468; Membrane ; Single-pass type I membrane protein In the muscle, expression localizes to the synaptic sites of muscle fibers. The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins. Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. nucleotide binding endocardial cushion development protein kinase activity transmembrane receptor protein tyrosine kinase activity protein binding ATP binding extracellular space nucleus integral component of plasma membrane protein phosphorylation negative regulation of cell adhesion signal transduction transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway nervous system development peripheral nervous system development positive regulation of cell proliferation basal plasma membrane negative regulation of signal transduction positive regulation of gene expression Schwann cell differentiation phosphatidylinositol 3-kinase signaling membrane integral component of membrane kinase activity phosphorylation basolateral plasma membrane apical plasma membrane lateral plasma membrane transferase activity peptidyl-tyrosine phosphorylation growth factor binding cranial nerve development protein tyrosine kinase activator activity ubiquitin protein ligase binding neuregulin receptor activity neuregulin binding regulation of cell proliferation identical protein binding receptor complex negative regulation of neuron apoptotic process postsynaptic membrane positive regulation of glucose import protein heterodimerization activity negative regulation of secretion neuron apoptotic process positive regulation of cardiac muscle tissue development positive regulation of protein tyrosine kinase activity positive regulation of calcineurin-NFAT signaling cascade extrinsic apoptotic signaling pathway in absence of ligand protein tyrosine kinase activity uc007hnm.1 uc007hnm.2 uc007hnm.3 
ENSMUST00000082065.4 Krtap6-2 ENSMUST00000082065.4 keratin associated protein 6-2 (from RefSeq NM_010673.2) A0A087WP75 A0A087WP75_MOUSE ENSMUST00000082065.1 ENSMUST00000082065.2 ENSMUST00000082065.3 Krtap6-2 NM_010673 uc007zvq.1 uc007zvq.2 uc007zvq.3 uc007zvq.1 uc007zvq.2 uc007zvq.3 
ENSMUST00000082085.5 Tas2r131 ENSMUST00000082085.5 taste receptor, type 2, member 131 (from RefSeq NM_207030.1) ENSMUST00000082085.1 ENSMUST00000082085.2 ENSMUST00000082085.3 ENSMUST00000082085.4 NM_207030 Q7M708 Q7M708_MOUSE Tas2r131 uc009ejw.1 uc009ejw.2 uc009ejw.3 Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Membrane ulti-pass membrane protein Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste molecular_function G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane response to stimulus sensory perception of taste uc009ejw.1 uc009ejw.2 uc009ejw.3 
ENSMUST00000082090.15 Ap3b2 ENSMUST00000082090.15 adaptor-related protein complex 3, beta 2 subunit (from RefSeq NM_021492.3) AP3B2_MOUSE B2RTK2 ENSMUST00000082090.1 ENSMUST00000082090.10 ENSMUST00000082090.11 ENSMUST00000082090.12 ENSMUST00000082090.13 ENSMUST00000082090.14 ENSMUST00000082090.2 ENSMUST00000082090.3 ENSMUST00000082090.4 ENSMUST00000082090.5 ENSMUST00000082090.6 ENSMUST00000082090.7 ENSMUST00000082090.8 ENSMUST00000082090.9 NM_021492 Q3UYP8 Q6QR53 Q8R1E5 Q9JME5 uc009iby.1 uc009iby.2 uc009iby.3 uc009iby.4 Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). AP- 3 associates with the BLOC-1 complex. Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Belongs to the adaptor complexes large subunit family. Golgi apparatus trans-Golgi network intracellular protein transport anterograde axonal transport protein transport membrane vesicle-mediated transport membrane coat AP-3 adaptor complex clathrin-coated vesicle membrane cytoplasmic vesicle anterograde synaptic vesicle transport axon cytoplasm uc009iby.1 uc009iby.2 uc009iby.3 uc009iby.4 
ENSMUST00000082093.7 Gzmd ENSMUST00000082093.7 granzyme D (from RefSeq NM_010372.2) ENSMUST00000082093.1 ENSMUST00000082093.2 ENSMUST00000082093.3 ENSMUST00000082093.4 ENSMUST00000082093.5 ENSMUST00000082093.6 GRAD_MOUSE NM_010372 P11033 P97387 Q3V2P1 uc007ubp.1 uc007ubp.2 uc007ubp.3 This enzyme is probably necessary for target cell lysis in cell-mediated immune responses. Cytolytic granule. Belongs to the peptidase S1 family. Granzyme subfamily. Sequence=AAB19190.1; Type=Erroneous gene model prediction; Evidence=; serine-type endopeptidase activity cytoplasm proteolysis peptidase activity serine-type peptidase activity granzyme-mediated apoptotic signaling pathway hydrolase activity cytolysis uc007ubp.1 uc007ubp.2 uc007ubp.3 
ENSMUST00000082094.5 Ptcd3 ENSMUST00000082094.5 pentatricopeptide repeat domain 3, transcript variant 4 (from RefSeq NR_155284.1) ENSMUST00000082094.1 ENSMUST00000082094.2 ENSMUST00000082094.3 ENSMUST00000082094.4 Mrps39 NR_155284 PTCD3_MOUSE Q14C51 Q3UKH5 Q5XG65 Q6P9N5 Q9CZ12 uc033isj.1 uc033isj.2 uc033isj.3 Mitochondrial RNA-binding protein that has a role in mitochondrial translation. Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Associated with the 12S mitochondrial rRNA (12S mt-rRNA) (By similarity). Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mS39 family. Sequence=BAB28668.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; RNA binding nucleoplasm mitochondrion cytosol ribosome plasma membrane regulation of translation rRNA binding mitochondrial translation ribosomal small subunit binding uc033isj.1 uc033isj.2 uc033isj.3 
ENSMUST00000082104.7 Csmd1 ENSMUST00000082104.7 CUB and Sushi multiple domains 1 (from RefSeq NM_053171.2) CSMD1_MOUSE E9QK23 ENSMUST00000082104.1 ENSMUST00000082104.2 ENSMUST00000082104.3 ENSMUST00000082104.4 ENSMUST00000082104.5 ENSMUST00000082104.6 NM_053171 Q8BUV1 Q8BYQ3 Q923L3 uc009kzp.1 uc009kzp.2 uc009kzp.3 Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q923L3-1; Sequence=Displayed; Name=2; IsoId=Q923L3-2; Sequence=VSP_009037; Name=3; IsoId=Q923L3-3; Sequence=VSP_009036; Belongs to the CSMD family. Sequence=BAC30095.1; Type=Erroneous initiation; Evidence=; startle response molecular_function cellular_component membrane integral component of membrane glucose homeostasis uc009kzp.1 uc009kzp.2 uc009kzp.3 
ENSMUST00000082120.5 Zfp42 ENSMUST00000082120.5 zinc finger protein 42, transcript variant 1 (from RefSeq NM_009556.4) E9QK22 E9QK22_MOUSE ENSMUST00000082120.1 ENSMUST00000082120.2 ENSMUST00000082120.3 ENSMUST00000082120.4 NM_009556 Zfp42 uc009lod.1 uc009lod.2 uc009lod.3 uc009lod.4 nucleic acid binding cytoplasm male gonad development female gonad development uc009lod.1 uc009lod.2 uc009lod.3 uc009lod.4 
ENSMUST00000082121.9 Glmn ENSMUST00000082121.9 glomulin, FKBP associated protein, transcript variant 2 (from RefSeq NM_001161738.1) ENSMUST00000082121.1 ENSMUST00000082121.2 ENSMUST00000082121.3 ENSMUST00000082121.4 ENSMUST00000082121.5 ENSMUST00000082121.6 ENSMUST00000082121.7 ENSMUST00000082121.8 Fap48 GLMN_MOUSE NM_001161738 Q3TFR5 Q8BZM1 Q99LB8 uc012eao.1 uc012eao.2 uc012eao.3 Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F- box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to the RING domain of RBX1 and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1 (By similarity). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (PubMed:22405651). Essential for normal development of the vasculature (PubMed:22405651). Contributes to the regulation of RPS6KB1 phosphorylation (By similarity). Interacts with FKBP4 and FKBP1A. Interacts with RBX1 (via RING domain). Identified in complexes that contain RBX1 plus one of the cullins CUL1, CUL2, CUL3, and CUL4A. Identified in a SCF complex composed of CUL1, RBX1, SKP1, FBXW7 and GLMN. Component of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN. Interacts with unphosphorylated MET and is released upon MET phosphorylation. Ubiquitous. Detected in embryonic vasculature and embryonic perichondrium, and in adult eye, brain, heart, testis, kidney, smooth muscle and skeletal muscle. The C-terminal half of the protein is important for interaction with RBX1. Phosphorylated on tyrosine residues. Complete embryonic lethality. Embryos are present at the expected Mendelian rate at 10.5 dpc, but all are dead by 12.5 dpc. Mutant embryos display decreased growth, delayed neural tube closure, incomplete axial turning, pericardial effusion and a failure to form an organized, functional vascular network. Mutant embryos have reduced protein levels of FBXW7, RBX1, CUL1, CUL2, CUL3 and CUL4A, due to increased proteasome-mediated degradation, and increased levels of CCNE1 and MYC. vasculogenesis neural tube closure receptor binding hepatocyte growth factor receptor binding protein binding cytoplasm cell surface receptor signaling pathway negative regulation of cell proliferation negative regulation of protein ubiquitination cullin-RING ubiquitin ligase complex Cul2-RING ubiquitin ligase complex Cul3-RING ubiquitin ligase complex Cul4A-RING E3 ubiquitin ligase complex ubiquitin protein ligase binding regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of gene expression, epigenetic negative regulation of T cell proliferation positive regulation of phosphorylation muscle cell differentiation positive regulation of interleukin-2 biosynthetic process positive regulation of cytokine secretion ubiquitin-protein transferase inhibitor activity circulatory system development uc012eao.1 uc012eao.2 uc012eao.3 
ENSMUST00000082134.6 Rps16 ENSMUST00000082134.6 ribosomal protein S16 (from RefSeq NM_013647.2) ENSMUST00000082134.1 ENSMUST00000082134.2 ENSMUST00000082134.3 ENSMUST00000082134.4 ENSMUST00000082134.5 NM_013647 P14131 Q3THM9 RS16_MOUSE uc012fgr.1 uc012fgr.2 uc012fgr.3 Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Component of the small ribosomal subunit (PubMed:36517592). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Cytoplasm Nucleus, nucleolus Belongs to the universal ribosomal protein uS9 family. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA binding structural constituent of ribosome ribosome rRNA processing translation small ribosomal subunit cytosolic small ribosomal subunit ribosomal small subunit biogenesis cellular response to leukemia inhibitory factor uc012fgr.1 uc012fgr.2 uc012fgr.3 
ENSMUST00000082152.5 Ube2o ENSMUST00000082152.5 ubiquitin-conjugating enzyme E2O, transcript variant 1 (from RefSeq NM_173755.4) A2A7X3 ENSMUST00000082152.1 ENSMUST00000082152.2 ENSMUST00000082152.3 ENSMUST00000082152.4 Kiaa1734 NM_173755 Q60800 Q6PCR9 Q6ZPJ3 Q7TPN2 Q8BLE8 UBE2O_MOUSE uc007mln.1 uc007mln.2 uc007mln.3 E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L- cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.24; Evidence= Inhibited by inorganic arsenite such as phenylarsenoxides. Protein modification; protein ubiquitination. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (PubMed:12522145). Interacts with UBR2 (PubMed:31268597). Cytoplasm Nucleus Note=Mainly localizes to the cytoplasm. Highly expressed in reticulocytes. By EPO/Erythropoietin which induces erythroid differentiation. Phosphorylated. Phosphorylation affects subcellular location. Ubiquitinated: autoubiquitinates, possibly affecting its subcellular location. Belongs to the ubiquitin-conjugating enzyme family. Sequence=AAA69916.1; Type=Frameshift; Evidence=; Sequence=AAH59193.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC32345.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC98241.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding ubiquitin-protein transferase activity cysteine-type endopeptidase inhibitor activity protein binding ATP binding nucleus cytoplasm cytosol ubiquitin-dependent protein catabolic process protein monoubiquitination negative regulation of endopeptidase activity protein ubiquitination nuclear body transferase activity positive regulation of BMP signaling pathway retrograde transport, endosome to Golgi negative regulation of apoptotic process ubiquitin protein ligase activity ubiquitin conjugating enzyme activity protein K63-linked ubiquitination uc007mln.1 uc007mln.2 uc007mln.3 
ENSMUST00000082175.7 Trim68 ENSMUST00000082175.7 tripartite motif-containing 68, transcript variant 1 (from RefSeq NM_198012.4) ENSMUST00000082175.1 ENSMUST00000082175.2 ENSMUST00000082175.3 ENSMUST00000082175.4 ENSMUST00000082175.5 ENSMUST00000082175.6 G3X9I6 G3X9I6_MOUSE NM_198012 Trim68 uc009isf.1 uc009isf.2 uc009isf.3 uc009isf.4 uc009isf.5 ubiquitin-protein transferase activity nucleus nucleolus cytoplasm Golgi apparatus cytosol zinc ion binding histone acetyltransferase binding metal ion binding androgen receptor binding protein autoubiquitination regulation of androgen receptor signaling pathway uc009isf.1 uc009isf.2 uc009isf.3 uc009isf.4 uc009isf.5 
ENSMUST00000082183.8 Zc3h12b ENSMUST00000082183.8 zinc finger CCCH-type containing 12B (from RefSeq NM_001034907.3) ENSMUST00000082183.1 ENSMUST00000082183.2 ENSMUST00000082183.3 ENSMUST00000082183.4 ENSMUST00000082183.5 ENSMUST00000082183.6 ENSMUST00000082183.7 G3X9I7 G3X9I7_MOUSE NM_001034907 Zc3h12b uc292png.1 uc292png.2 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the ZC3H12 family. molecular_function cellular_component biological_process metal ion binding uc292png.1 uc292png.2 
ENSMUST00000082197.12 Hdac10 ENSMUST00000082197.12 histone deacetylase 10, transcript variant 2 (from RefSeq NR_028447.1) ENSMUST00000082197.1 ENSMUST00000082197.10 ENSMUST00000082197.11 ENSMUST00000082197.2 ENSMUST00000082197.3 ENSMUST00000082197.4 ENSMUST00000082197.5 ENSMUST00000082197.6 ENSMUST00000082197.7 ENSMUST00000082197.8 ENSMUST00000082197.9 G3X9I8 HDA10_MOUSE NR_028447 Q6P3E7 uc007xfj.1 uc007xfj.2 uc007xfj.3 uc007xfj.4 Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair. Reaction=H2O + N(8)-acetylspermidine = acetate + spermidine; Xref=Rhea:RHEA:23928, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:57834, ChEBI:CHEBI:58535; EC=3.5.1.48; Evidence=; Reaction=H2O + N-acetylputrescine = acetate + putrescine; Xref=Rhea:RHEA:23412, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:58263, ChEBI:CHEBI:326268; EC=3.5.1.62; Evidence=; Reaction=H2O + N-acetylcadaverine = acetate + cadaverine; Xref=Rhea:RHEA:51892, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:58384, ChEBI:CHEBI:134408; Evidence=; Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl- [protein]; Xref=Rhea:RHEA:58108, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; Evidence=; Interacts with HDAC3. Interacts with HDAC2 and NCOR2/SMRT. Interacts with HSPA8/HSC70. Interacts with MSH2. Cytoplasm Nucleus Note=Excluded from nucleoli. widely expressed. Belongs to the histone deacetylase family. HD type 2 subfamily. Protein/histone deacetylase activity in vivo is uncertain. The 3D structure analysis of the zebrafish ortholog shows that a glutamate gatekeeper and a sterically constricted active site confer specificity for N(8)-acetylspermidine hydrolysis and disfavour acetyllysine hydrolysis. Supporting this observation, has been shown to exhibit only very low activity, if any, towards acetyl-lysine peptide substrates. However, histone deacetylase activity has been observed in vitro and HDAC10 has also been shown to be involved in MSH2 deacetylation. histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter histone deacetylase activity nucleus nucleoplasm cytoplasm DNA repair DNA recombination regulation of transcription, DNA-templated autophagy cellular response to DNA damage stimulus zinc ion binding macroautophagy histone deacetylation hydrolase activity deacetylase activity enzyme binding positive regulation of mismatch repair protein deacetylase activity peptidyl-lysine deacetylation reciprocal DNA recombination histone deacetylase binding negative regulation of transcription, DNA-templated metal ion binding acetylputrescine deacetylase activity acetylspermidine deacetylase activity protein deacetylation uc007xfj.1 uc007xfj.2 uc007xfj.3 uc007xfj.4 
ENSMUST00000082209.13 Scn8a ENSMUST00000082209.13 sodium channel, voltage-gated, type VIII, alpha, transcript variant 1 (from RefSeq NM_001077499.2) ENSMUST00000082209.1 ENSMUST00000082209.10 ENSMUST00000082209.11 ENSMUST00000082209.12 ENSMUST00000082209.2 ENSMUST00000082209.3 ENSMUST00000082209.4 ENSMUST00000082209.5 ENSMUST00000082209.6 ENSMUST00000082209.7 ENSMUST00000082209.8 ENSMUST00000082209.9 F6U329 F6U329_MOUSE NM_001077499 Scn8a uc007xsh.1 uc007xsh.2 uc007xsh.3 uc007xsh.4 Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the sodium channel (TC 1.A.1.10) family. Lacks conserved residue(s) required for the propagation of feature annotation. voltage-gated sodium channel complex ion channel activity voltage-gated ion channel activity voltage-gated sodium channel activity sodium channel activity plasma membrane ion transport sodium ion transport membrane integral component of membrane ion transmembrane transport regulation of ion transmembrane transport sodium ion transmembrane transport transmembrane transport uc007xsh.1 uc007xsh.2 uc007xsh.3 uc007xsh.4 
ENSMUST00000082214.5 Cyp2b9 ENSMUST00000082214.5 cytochrome P450, family 2, subfamily b, polypeptide 9 (from RefSeq NM_010000.2) CP2B9_MOUSE Cyp2b-9 ENSMUST00000082214.1 ENSMUST00000082214.2 ENSMUST00000082214.3 ENSMUST00000082214.4 NM_010000 P12790 Q64463 Rip uc009fuh.1 uc009fuh.2 uc009fuh.3 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding organelle membrane response to stilbenoid exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc009fuh.1 uc009fuh.2 uc009fuh.3 
ENSMUST00000082219.6 Chil4 ENSMUST00000082219.6 chitinase-like 4 (from RefSeq NM_145126.2) CHIL4_MOUSE Chi3l4 ENSMUST00000082219.1 ENSMUST00000082219.2 ENSMUST00000082219.3 ENSMUST00000082219.4 ENSMUST00000082219.5 NM_145126 Q3V2C9 Q8VH43 Q8VHG1 Q91Z98 Ym2 uc008qvx.1 uc008qvx.2 uc008qvx.3 uc008qvx.4 Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity. Secreted. Cytoplasm. Note=Detected in the cytoplasm of keratinocytes. Detected in stratified squamous epithelium in the junctional region between forestomach and glandular stomach (at protein level). Expression is mainly restricted to stomach. Up-regulated in response to IL4 and IL13 and during the allergic response. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. chitinase activity extracellular region cytoplasm carbohydrate metabolic process chitin catabolic process inflammatory response chitin binding uc008qvx.1 uc008qvx.2 uc008qvx.3 uc008qvx.4 
ENSMUST00000082223.13 Rpl5 ENSMUST00000082223.13 ribosomal protein L5 (from RefSeq NM_016980.2) ENSMUST00000082223.1 ENSMUST00000082223.10 ENSMUST00000082223.11 ENSMUST00000082223.12 ENSMUST00000082223.2 ENSMUST00000082223.3 ENSMUST00000082223.4 ENSMUST00000082223.5 ENSMUST00000082223.6 ENSMUST00000082223.7 ENSMUST00000082223.8 ENSMUST00000082223.9 NM_016980 Q58EU6 Q58EU6_MOUSE Rpl5 uc008ynh.1 uc008ynh.2 uc008ynh.3 uc008ynh.4 Belongs to the universal ribosomal protein uL18 family. mRNA binding structural constituent of ribosome ribosome translation 5S rRNA binding positive regulation of phosphatase activity postsynaptic density aminoacyl-tRNA synthetase multienzyme complex cytosolic large ribosomal subunit cytosolic ribosome cellular response to inorganic substance positive regulation of isoleucine-tRNA ligase activity positive regulation of methionine-tRNA ligase activity positive regulation of threonine-tRNA ligase activity ribonucleoprotein complex uc008ynh.1 uc008ynh.2 uc008ynh.3 uc008ynh.4 
ENSMUST00000082235.5 Mep1b ENSMUST00000082235.5 meprin 1 beta (from RefSeq NM_008586.2) ENSMUST00000082235.1 ENSMUST00000082235.2 ENSMUST00000082235.3 ENSMUST00000082235.4 MEP1B_MOUSE Mep-1b NM_008586 Q059K0 Q61847 uc008eff.1 uc008eff.2 Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position (PubMed:11278902). Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components (By similarity). Reaction=Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of 5-His-|-Leu-6, 6-Leu-|-Cys-7, 14-Ala-|-Leu-15 and 19- Cys-|-Gly-20 bonds in insulin B chain.; EC=3.4.24.63; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. Strongly inhibited by fetuin-A/AHSG (By similarity). Inhibited by cysteine and by the metal ion chelators EDTA and 1,10-phenanthroline. Not inhibited by 3,4-dichloroisocourmarin, soybean trypsin inhibitor, or the cysteine proteinase inhibitors iodoacetic acid and E-64. Temperature dependence: The half-life at 58 degrees Celsius is less than 3 minutes. ; Homotetramer consisting of disulfide-linked beta subunits, or heterotetramer of two alpha and two beta subunits formed by non- covalent association of two disulfide-linked heterodimers. Interacts with MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity. Cell membrane ; Single-pass type I membrane protein Secreted Note=Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17. Event=Alternative promoter usage, Alternative splicing; Named isoforms=2; Name=1; Synonyms=Beta; IsoId=Q61847-1; Sequence=Displayed; Name=2; Synonyms=Beta'; IsoId=Q61847-2; Sequence=VSP_005460; Isoform 1 is expressed in kidney, intestinal brush borders, and salivary ducts. Isoform 2 has been found in carcinoma cells. By retinoic acid. Proteolytically activated by trypsin in the intestinal lumen and kallikrein-related peptidases in other tissues. N-glycosylated; contains high mannose and/or complex biantennary structures. metalloendopeptidase activity extracellular region plasma membrane integral component of plasma membrane proteolysis inflammatory response peptidase activity metallopeptidase activity zinc ion binding membrane integral component of membrane hydrolase activity meprin A complex identical protein binding metal ion binding toxin transport uc008eff.1 uc008eff.2 
ENSMUST00000082237.7 Mex3b ENSMUST00000082237.7 mex3 RNA binding family member B (from RefSeq NM_175366.3) ENSMUST00000082237.1 ENSMUST00000082237.2 ENSMUST00000082237.3 ENSMUST00000082237.4 ENSMUST00000082237.5 ENSMUST00000082237.6 F8WJD6 F8WJD6_MOUSE Mex3b NM_175366 uc009idj.1 uc009idj.2 uc009idj.3 uc009idj.4 Cytoplasm Nucleus nucleic acid binding RNA binding nucleoplasm cytosol uc009idj.1 uc009idj.2 uc009idj.3 uc009idj.4 
ENSMUST00000082254.8 Jakmip2 ENSMUST00000082254.8 janus kinase and microtubule interacting protein 2 (from RefSeq NM_001163637.1) D3YXK0 D3YXK0_MOUSE ENSMUST00000082254.1 ENSMUST00000082254.2 ENSMUST00000082254.3 ENSMUST00000082254.4 ENSMUST00000082254.5 ENSMUST00000082254.6 ENSMUST00000082254.7 Jakmip2 NM_001163637 uc008euk.1 uc008euk.2 uc008euk.3 uc008euk.4 Belongs to the JAKMIP family. molecular_function Golgi apparatus microtubule binding biological_process kinase binding uc008euk.1 uc008euk.2 uc008euk.3 uc008euk.4 
ENSMUST00000082269.3 3110018I06Rik ENSMUST00000082269.3 3110018I06Rik (from geneSymbol) AK014062 ENSMUST00000082269.1 ENSMUST00000082269.2 uc288jas.1 uc288jas.2 uc288jas.1 uc288jas.2 
ENSMUST00000082287.3 Mup5 ENSMUST00000082287.3 major urinary protein 5 (from RefSeq NM_008649.2) A2RSZ7 B5TE77 ENSMUST00000082287.1 ENSMUST00000082287.2 MUP5_MOUSE Mup18 Mup5 NM_008649 P11591 uc008tbq.1 uc008tbq.2 uc008tbq.3 Major urinary proteins (Mups) bind pheromones, and thus stabilize them to allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance. Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function insulin-activated receptor activity pheromone binding extracellular region extracellular space nucleus cytosol energy reserve metabolic process behavior biological_process insulin receptor signaling pathway aerobic respiration positive regulation of gene expression negative regulation of lipid storage positive regulation of glucose metabolic process heat generation small molecule binding glucose homeostasis locomotor rhythm negative regulation of gluconeogenesis positive regulation of lipid metabolic process negative regulation of transcription, DNA-templated negative regulation of lipid biosynthetic process positive regulation of protein kinase B signaling negative regulation of insulin secretion involved in cellular response to glucose stimulus mitochondrion morphogenesis cellular response to lipid uc008tbq.1 uc008tbq.2 uc008tbq.3 
ENSMUST00000082290.8 Slc39a12 ENSMUST00000082290.8 solute carrier family 39 (zinc transporter), member 12, transcript variant 6 (from RefSeq NR_183249.1) A2AQ76 ENSMUST00000082290.1 ENSMUST00000082290.2 ENSMUST00000082290.3 ENSMUST00000082290.4 ENSMUST00000082290.5 ENSMUST00000082290.6 ENSMUST00000082290.7 NR_183249 Q5FWH7 S39AC_MOUSE Slc39a12 Zip12 uc008ikl.1 uc008ikl.2 uc008ikl.3 uc008ikl.4 Uniporter that promotes Zn(2+) import from the extracellular space to the cytoplasm across the cell membrane (PubMed:23716681, PubMed:35065654). The transport activity is temperature dependent (PubMed:23716681). May play a role in neurulation and neurite extension (PubMed:23716681). May play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis (PubMed:35065654). Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence= Kinetic parameters: KM=6.6 nM for zinc (2+) ion ; Vmax=2.7 pmol/min/mg protein; Membrane ; Multi- pass membrane protein Note=At low Zn(2+) extracellular concentration, is redistributed from the perinuclear space to the cytoplasm and plasma membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5FWH7-1; Sequence=Displayed; Name=2; IsoId=Q5FWH7-2; Sequence=VSP_029851; Highly expressed in brain, namely in the hippocampus, frontal cortex, striatum, hypothalamus, and cerebellum (at protein level) (PubMed:23716681, PubMed:35065654). Also expressed in neurons in the Purkinje cell layer of the cerebellum, medulla oblongata, and the frontal cortex (PubMed:23716681). Abundantly expressed in the testis, namely in the spermatogonia and spermatids within the seminiferous tubules (PubMed:35065654). Belongs to the ZIP transporter (TC 2.A.5) family. zinc ion transmembrane transporter activity plasma membrane integral component of plasma membrane cellular zinc ion homeostasis signal transduction regulation of neuron projection development membrane integral component of membrane metal ion transport regulation of microtubule polymerization metal ion transmembrane transporter activity perinuclear region of cytoplasm transmembrane transport zinc II ion transmembrane import uc008ikl.1 uc008ikl.2 uc008ikl.3 uc008ikl.4 
ENSMUST00000082306.8 4930522H14Rik ENSMUST00000082306.8 RIKEN cDNA 4930522H14 gene, transcript variant 2 (from RefSeq NM_001199090.1) CA185_MOUSE ENSMUST00000082306.1 ENSMUST00000082306.2 ENSMUST00000082306.3 ENSMUST00000082306.4 ENSMUST00000082306.5 ENSMUST00000082306.6 ENSMUST00000082306.7 NM_001199090 Q9CPZ3 Q9DAM0 uc008uco.1 uc008uco.2 uc008uco.3 uc008uco.4 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CPZ3-1; Sequence=Displayed; Name=2; IsoId=Q9CPZ3-2; Sequence=VSP_022279; molecular_function cellular_component biological_process membrane integral component of membrane uc008uco.1 uc008uco.2 uc008uco.3 uc008uco.4 
ENSMUST00000082320.12 Porcn ENSMUST00000082320.12 porcupine O-acyltransferase, transcript variant b (from RefSeq NM_145908.4) A2AC30 A2AC32 A2AC33 ENSMUST00000082320.1 ENSMUST00000082320.10 ENSMUST00000082320.11 ENSMUST00000082320.2 ENSMUST00000082320.3 ENSMUST00000082320.4 ENSMUST00000082320.5 ENSMUST00000082320.6 ENSMUST00000082320.7 ENSMUST00000082320.8 ENSMUST00000082320.9 NM_145908 PORCN_MOUSE Porc Porcn Ppn Q9CWT0 Q9JJJ7 Q9JJJ8 Q9JJJ9 Q9JJK0 uc009sok.1 uc009sok.2 uc009sok.3 uc009sok.4 uc009sok.5 Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. Reaction=(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA; Xref=Rhea:RHEA:45336, Rhea:RHEA-COMP:11170, Rhea:RHEA-COMP:11171, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:85189; EC=2.3.1.250; Evidence= Interacts with WNT1, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A and WNT7B. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=D; IsoId=Q9JJJ7-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9JJJ7-2; Sequence=VSP_015892; Name=3; Synonyms=C; IsoId=Q9JJJ7-3; Sequence=VSP_015891; Name=4; Synonyms=A; IsoId=Q9JJJ7-4; Sequence=VSP_015890; Name=5; IsoId=Q9JJJ7-5; Sequence=VSP_015889, VSP_015893; Expressed in brain, heart, kidney, liver, lung, muscle, spleen and testis. Isoform 4 is strongly expressed in kidney, liver, lung, spleen and testis. Isoform 1 is strongly expressed in brain, heart and muscle and poorly in kidney, liver, lung, spleen and testis. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed at different levels in embryo at 9.5, 10.5, 11.5, 12.5, 13.5 and 15.5 dpc. Belongs to the membrane-bound acyltransferase family. Porcupine subfamily. Was initially thought to mediate palmitoylation of Wnt proteins. It was later shown that instead it acts as a serine O- palmitoleoyltransferase that mediates the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins (PubMed:17141155, PubMed:24798332). protein binding endoplasmic reticulum endoplasmic reticulum membrane protein lipidation O-acyltransferase activity glycoprotein metabolic process membrane integral component of membrane Wnt signaling pathway transferase activity transferase activity, transferring acyl groups Wnt-protein binding integral component of endoplasmic reticulum membrane AMPA glutamate receptor complex protein palmitoleylation canonical Wnt signaling pathway glutamatergic synapse regulation of postsynaptic specialization membrane neurotransmitter receptor levels palmitoleoyltransferase activity uc009sok.1 uc009sok.2 uc009sok.3 uc009sok.4 uc009sok.5 
ENSMUST00000082337.13 Mdc1 ENSMUST00000082337.13 mediator of DNA damage checkpoint 1, transcript variant 10 (from RefSeq NM_001405529.1) E9QK89 E9QK89_MOUSE ENSMUST00000082337.1 ENSMUST00000082337.10 ENSMUST00000082337.11 ENSMUST00000082337.12 ENSMUST00000082337.2 ENSMUST00000082337.3 ENSMUST00000082337.4 ENSMUST00000082337.5 ENSMUST00000082337.6 ENSMUST00000082337.7 ENSMUST00000082337.8 ENSMUST00000082337.9 Mdc1 NM_001405529 uc008cir.1 uc008cir.2 uc008cir.3 Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. Chromosome uc008cir.1 uc008cir.2 uc008cir.3 
ENSMUST00000082357.2 Samt2b ENSMUST00000082357.2 spermatogenesis associated multipass transmembrane protein 2b (from RefSeq NM_001256259.1) 4930524N10Rik ENSMUST00000082357.1 NM_001256259 Q9D519 Q9D519_MOUSE Samt2b uc029xnv.1 uc029xnv.2 Cell junction, tight junction Belongs to the claudin family. molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc029xnv.1 uc029xnv.2 
ENSMUST00000082365.6 Sult4a1 ENSMUST00000082365.6 sulfotransferase family 4A, member 1, transcript variant 1 (from RefSeq NM_013873.3) ENSMUST00000082365.1 ENSMUST00000082365.2 ENSMUST00000082365.3 ENSMUST00000082365.4 ENSMUST00000082365.5 NM_013873 O88872 P63046 Q3TXY5 Q91XS5 Q9CWY7 Q9DC97 ST4A1_MOUSE Sultx3 uc007xbs.1 uc007xbs.2 Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p- nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P63046-1, Q9DC97-1; Sequence=Displayed; Name=2; IsoId=P63046-2, Q9DC97-2; Sequence=VSP_006305; Expressed in brain, cerebellum and hypothalamus. Not detected in pancreas, liver, lung, intestine, kidney, uterus, adrenal gland, thymus, spleen, epididymis, testicle, and heart. Belongs to the sulfotransferase 1 family. cytoplasm lipid metabolic process sulfur compound metabolic process sulfotransferase activity steroid metabolic process transferase activity identical protein binding uc007xbs.1 uc007xbs.2 
ENSMUST00000082373.8 Luzp2 ENSMUST00000082373.8 leucine zipper protein 2 (from RefSeq NM_178705.5) ENSMUST00000082373.1 ENSMUST00000082373.2 ENSMUST00000082373.3 ENSMUST00000082373.4 ENSMUST00000082373.5 ENSMUST00000082373.6 ENSMUST00000082373.7 LUZP2_MOUSE NM_178705 Q7TPB5 Q8BGY3 Q8CBZ7 uc009hcx.1 uc009hcx.2 uc009hcx.3 Secreted Expression found only in the brain and spinal cord. molecular_function cellular_component extracellular region biological_process uc009hcx.1 uc009hcx.2 uc009hcx.3 
ENSMUST00000082387.1 mt-Tf ENSMUST00000082387.1 mt-Tf (from geneSymbol) uc292msr.1 uc292msr.1 
ENSMUST00000082388.1 mt-Rnr1 ENSMUST00000082388.1 mt-Rnr1 (from geneSymbol) AK142736 uc009vev.1 uc009vev.2 uc009vev.1 uc009vev.2 
ENSMUST00000082389.1 mt-Tv ENSMUST00000082389.1 mt-Tv (from geneSymbol) uc292mss.1 uc292mss.1 
ENSMUST00000082390.1 mt-Rnr2 ENSMUST00000082390.1 mt-Rnr2 (from geneSymbol) AK131596 uc009vew.1 uc009vew.2 uc009vew.1 uc009vew.2 
ENSMUST00000082391.1 mt-Tl1 ENSMUST00000082391.1 mt-Tl1 (from geneSymbol) BC052873 uc292mst.1 uc292mst.1 
ENSMUST00000082392.1 mt-Nd1 ENSMUST00000082392.1 Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence= (from UniProt Q4JFN6) AK131578 ND1 Nd1 Q4JFN6 Q4JFN6_MOUSE mt-Nd1 uc292msu.1 Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence= Membrane ; Multi- pass membrane protein Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the complex I subunit 1 family. mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I NADH dehydrogenase (ubiquinone) activity response to organic cyclic compound membrane integral component of membrane oxidoreductase activity dendrite mitochondrial membrane response to hydroperoxide response to drug neuronal cell body oxidation-reduction process uc292msu.1 
ENSMUST00000082393.1 mt-Ti ENSMUST00000082393.1 mt-Ti (from geneSymbol) uc292msv.1 uc292msv.1 
ENSMUST00000082394.1 mt-Tq ENSMUST00000082394.1 mt-Tq (from geneSymbol) uc292msw.1 uc292msw.1 
ENSMUST00000082395.1 mt-Tm ENSMUST00000082395.1 mt-Tm (from geneSymbol) AK139000 uc009vex.1 uc009vex.2 uc009vex.3 uc009vex.1 uc009vex.2 uc009vex.3 
ENSMUST00000082396.1 mt-Nd2 ENSMUST00000082396.1 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. (from UniProt Q9MD59) AK163440 ND2 Nd2 Q9MD59 Q9MD59_MOUSE mt-ND2 mt-Nd2 uc292msx.1 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence= Membrane ; Multi- pass membrane protein Mitochondrion inner membrane ulti-pass membrane protein Belongs to the complex I subunit 2 family. mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial electron transport, NADH to ubiquinone NADH dehydrogenase (ubiquinone) activity membrane integral component of membrane oxidoreductase activity oxidation-reduction process respiratory chain uc292msx.1 
ENSMUST00000082397.1 mt-Tw ENSMUST00000082397.1 mt-Tw (from geneSymbol) uc292msy.1 uc292msy.1 
ENSMUST00000082398.1 mt-Ta ENSMUST00000082398.1 mt-Ta (from geneSymbol) uc292msz.1 uc292msz.1 
ENSMUST00000082399.1 mt-Tn ENSMUST00000082399.1 mt-Tn (from geneSymbol) uc292mta.1 uc292mta.1 
ENSMUST00000082400.1 mt-Tc ENSMUST00000082400.1 mt-Tc (from geneSymbol) uc292mtb.1 uc292mtb.1 
ENSMUST00000082401.1 mt-Ty ENSMUST00000082401.1 mt-Ty (from geneSymbol) uc292mtc.1 uc292mtc.1 
ENSMUST00000082402.1 mt-Co1 ENSMUST00000082402.1 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. (from UniProt Q9MD68) AK166684 COI COX1 COXI Q9MD68 Q9MD68_MOUSE mt-COI mt-Co1 uc292mtd.1 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)- [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436, Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=7.1.1.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11437; Evidence=; Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Energy metabolism; oxidative phosphorylation. Membrane ; Multi- pass membrane protein Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the heme-copper respiratory oxidase family. cytochrome-c oxidase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex III mitochondrial respiratory chain complex IV oxidative phosphorylation response to oxidative stress aging aerobic respiration membrane integral component of membrane oxidoreductase activity heme binding cerebellum development electron transport chain respiratory chain complex IV response to copper ion metal ion binding response to electrical stimulus oxidation-reduction process respiratory chain hydrogen ion transmembrane transport uc292mtd.1 
ENSMUST00000082403.1 mt-Ts1 ENSMUST00000082403.1 mt-Ts1 (from geneSymbol) uc292mte.1 uc292mte.1 
ENSMUST00000082404.1 mt-Td ENSMUST00000082404.1 mt-Td (from geneSymbol) AF378830 uc009vez.1 uc009vez.2 uc009vez.1 uc009vez.2 
ENSMUST00000082405.1 mt-Co2 ENSMUST00000082405.1 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. (from UniProt Q7JCZ1) AK131586 COII COX2 COXII Co2 Cox2 Q7JCZ1 Q7JCZ1_MOUSE mt-COII mt-Co2 uc292mtf.1 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)- [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436, Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=7.1.1.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11437; Evidence=; Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Note=Binds a copper A center. ; Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16. Membrane ; Multi- pass membrane protein Mitochondrion inner membrane ulti-pass membrane protein Belongs to the cytochrome c oxidase subunit 2 family. cytochrome-c oxidase activity copper ion binding mitochondrion mitochondrial inner membrane lactation response to cold positive regulation of hydrogen peroxide biosynthetic process positive regulation of necrotic cell death membrane integral component of membrane oxidoreductase activity electron transport chain respiratory chain complex IV metal ion binding oxidation-reduction process respiratory chain hydrogen ion transmembrane transport positive regulation of ATP biosynthetic process uc292mtf.1 
ENSMUST00000082406.1 mt-Tk ENSMUST00000082406.1 mt-Tk (from geneSymbol) AK131587 uc292mtg.1 uc292mtg.1 
ENSMUST00000082407.1 mt-Atp8 ENSMUST00000082407.1 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. (from UniProt Q7JCZ0) AK131577 ATP8 ATPase 8 ATPase8 Atp8 Q7JCZ0 Q7JCZ0_MOUSE mt-ATP8 mt-Atp6 mt-Atp8 uc292mth.1 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Membrane ; Single- pass membrane protein Mitochondrion membrane ingle-pass membrane protein Belongs to the ATPase protein 8 family. mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) mitochondrion ATP biosynthetic process ion transport hydrogen ion transmembrane transporter activity ATP synthesis coupled proton transport membrane integral component of membrane oxidoreductase activity hydrolase activity mitochondrial membrane proton-transporting ATP synthase complex, coupling factor F(o) oxidation-reduction process uc292mth.1 
ENSMUST00000082408.1 mt-Atp6 ENSMUST00000082408.1 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane. (from UniProt Q7JCY9) ATP6 ATPase 6 ATPase6 Atp6 BC008260 Q7JCY9 Q7JCY9_MOUSE mt-ATP6 uc292mti.1 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane. Membrane ; Multi- pass membrane protein Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the ATPase A chain family. mitochondrion mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex aging hydrogen ion transmembrane transporter activity ATP synthesis coupled proton transport membrane integral component of membrane hydrolase activity ATPase activity proton-transporting ATP synthase complex, coupling factor F(o) response to hyperoxia uc292mti.1 
ENSMUST00000082409.1 mt-Co3 ENSMUST00000082409.1 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. (from UniProt Q7JCX7) AK131579 COIII COX3 COXIII Co3 Q7JCX7 Q7JCX7_MOUSE mt-COIII mt-Co3 uc292mtj.1 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)- [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436, Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=7.1.1.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11437; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the cytochrome c oxidase subunit 3 family. cytochrome-c oxidase activity mitochondrion respiratory chain complex IV assembly heme-copper terminal oxidase activity membrane integral component of membrane oxidoreductase activity aerobic electron transport chain respiratory electron transport chain respiratory chain complex IV oxidation-reduction process hydrogen ion transmembrane transport uc292mtj.1 
ENSMUST00000082410.1 mt-Tg ENSMUST00000082410.1 mt-Tg (from geneSymbol) BC012020 uc292mtk.1 uc292mtk.1 
ENSMUST00000082411.1 mt-Nd3 ENSMUST00000082411.1 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I. (from UniProt Q7GIP5) AK139029 ND3 Nd3 Q7GIP5 Q7GIP5_MOUSE mt-ND3 mt-Nd3 uc292mtl.1 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I. Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence= Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242. Mitochondrion membrane ; Multi-pass membrane protein Belongs to the complex I subunit 3 family. mitochondrion mitochondrial respiratory chain complex I response to oxidative stress NADH dehydrogenase (ubiquinone) activity response to light intensity response to hormone membrane integral component of membrane oxidoreductase activity mitochondrial membrane oxidation-reduction process respiratory chain cellular response to glucocorticoid stimulus uc292mtl.1 
ENSMUST00000082412.1 mt-Tr ENSMUST00000082412.1 mt-Tr (from geneSymbol) uc292mtm.1 uc292mtm.1 
ENSMUST00000082414.1 mt-Nd4 ENSMUST00000082414.1 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. (from UniProt Q7JCY6) BC020382 ND4 Nd4 Q7JCY6 Q7JCY6_MOUSE mt-Nd4 uc292mtn.1 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence= Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Membrane ; Multi- pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Belongs to the complex I subunit 4 family. response to hypoxia in utero embryonic development mitochondrion mitochondrial respiratory chain complex I mitochondrial electron transport, NADH to ubiquinone aging NADH dehydrogenase (ubiquinone) activity membrane integral component of membrane oxidoreductase activity cerebellum development mitochondrial membrane response to nicotine ATP synthesis coupled electron transport response to ethanol oxidation-reduction process respiratory chain uc292mtn.1 
ENSMUST00000082415.1 mt-Th ENSMUST00000082415.1 mt-Th (from geneSymbol) uc292mto.1 uc292mto.1 
ENSMUST00000082416.1 mt-Ts2 ENSMUST00000082416.1 mt-Ts2 (from geneSymbol) uc292mtp.1 uc292mtp.1 
ENSMUST00000082417.1 mt-Tl2 ENSMUST00000082417.1 mt-Tl2 (from geneSymbol) uc292mtq.1 uc292mtq.1 
ENSMUST00000082418.1 mt-Nd5 ENSMUST00000082418.1 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. (from UniProt Q9MD82) AK140457 ND5 Nd5 Q9MD82 Q9MD82_MOUSE mt-ND5 mt-Nd5 mt-Nd6 uc292mtr.1 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence= Membrane ; Multi- pass membrane protein Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the complex I subunit 5 family. mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I NADH dehydrogenase (ubiquinone) activity membrane integral component of membrane oxidoreductase activity ATP synthesis coupled electron transport oxidation-reduction process respiratory chain uc292mtr.1 
ENSMUST00000082419.1 mt-Nd6 ENSMUST00000082419.1 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. (from UniProt Q7JCY4) AK140300 ND6 Nd6 Q7JCY4 Q7JCY4_MOUSE mt-Nd6 uc292mts.1 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence= Mitochondrion membrane ; Multi-pass membrane protein Belongs to the complex I subunit 6 family. mitochondrion NADH dehydrogenase (ubiquinone) activity membrane integral component of membrane oxidoreductase activity mitochondrial membrane response to nicotine response to cocaine response to hydrogen peroxide oxidation-reduction process respiratory chain uc292mts.1 
ENSMUST00000082420.1 mt-Te ENSMUST00000082420.1 mt-Te (from geneSymbol) AB351264 uc292mtt.1 uc292mtt.1 
ENSMUST00000082421.1 mt-Cytb ENSMUST00000082421.1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (from UniProt Q7JCZ3) AK131866 CYTB Cytb Q7JCZ3 Q7JCZ3_MOUSE cytb mt-CYTB mt-Cytb uc292mtu.1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 2 heme groups non-covalently. ; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Note=Binds 2 heme groups non-covalently. ; The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. Membrane ; Multi- pass membrane protein Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the cytochrome b family. response to hypoxia mitochondrion mitochondrial inner membrane mitochondrial electron transport, ubiquinol to cytochrome c response to nutrient ubiquinol-cytochrome-c reductase activity electron carrier activity response to heat response to toxic substance response to hormone response to organonitrogen compound response to organic cyclic compound electron transport coupled proton transport membrane integral component of membrane oxidoreductase activity respiratory electron transport chain animal organ regeneration integral component of mitochondrial inner membrane macromolecular complex response to cobalamin response to glucagon response to drug hyperosmotic salinity response macromolecular complex binding respiratory chain complex III response to ethanol response to cadmium ion response to copper ion response to mercury ion metal ion binding response to calcium ion response to hyperoxia oxidation-reduction process respiratory chain uc292mtu.1 
ENSMUST00000082422.1 mt-Tt ENSMUST00000082422.1 mt-Tt (from geneSymbol) uc292mtv.1 uc292mtv.1 
ENSMUST00000082423.1 mt-Tp ENSMUST00000082423.1 mt-Tp (from geneSymbol) uc292mtw.1 uc292mtw.1 
ENSMUST00000082424.12 Selenop ENSMUST00000082424.12 selenoprotein P, transcript variant 2 (from RefSeq NM_001042613.2) ENSMUST00000082424.1 ENSMUST00000082424.10 ENSMUST00000082424.11 ENSMUST00000082424.2 ENSMUST00000082424.3 ENSMUST00000082424.4 ENSMUST00000082424.5 ENSMUST00000082424.6 ENSMUST00000082424.7 ENSMUST00000082424.8 ENSMUST00000082424.9 NM_001042613 P70274 Q3TJ31 Q3TXG8 Q6PKE7 Q80T08 Q80UF3 Q9Z2T7 SEPP1_MOUSE Selenop Selp Sepp1 uc007vby.1 uc007vby.2 This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in mouse), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants differing in 5' non-coding region have been described for this gene. Expression of these variants varies in different tissues and developmental stages (PMID:23064117). [provided by RefSeq, Feb 2017]. Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium (By similarity). May supply selenium to tissues such as brain and testis. Secreted Note=Passes from plasma into the glomerular filtrate where it is removed by endocytosis mediated by LRP2 in the proximal tubule epithelium. In the kidney, expressed in the cortex with no expression observed in the medulla (at protein level) (PubMed:18174160). Expressed by the liver and secreted in plasma (PubMed:9687017). The C-terminus is not required for endocytic uptake in the proximal tubule epithelium. Phosphorylation sites are present in the extracellular medium. Belongs to the selenoprotein P family. selenium compound metabolic process protein binding extracellular region extracellular space brain development locomotory behavior selenium binding post-embryonic development response to selenium ion sexual reproduction regulation of growth uc007vby.1 uc007vby.2 
ENSMUST00000082426.11 Dio1 ENSMUST00000082426.11 deiodinase, iodothyronine, type I (from RefSeq NM_007860.4) A0A0R4J110 A0A0R4J110_MOUSE Dio1 ENSMUST00000082426.1 ENSMUST00000082426.10 ENSMUST00000082426.2 ENSMUST00000082426.3 ENSMUST00000082426.4 ENSMUST00000082426.5 ENSMUST00000082426.6 ENSMUST00000082426.7 ENSMUST00000082426.8 ENSMUST00000082426.9 NM_007860 uc008tzq.1 uc008tzq.2 uc008tzq.3 uc008tzq.4 The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Apr 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC019786.1, U49861.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 8419134 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). Endoplasmic reticulum membrane ; Single-pass membrane protein Belongs to the iodothyronine deiodinase family. thyroxine 5'-deiodinase activity oxidoreductase activity hormone biosynthetic process oxidation-reduction process uc008tzq.1 uc008tzq.2 uc008tzq.3 uc008tzq.4 
ENSMUST00000082428.6 Sephs2 ENSMUST00000082428.6 selenophosphate synthetase 2 (from RefSeq NM_009266.3) ENSMUST00000082428.1 ENSMUST00000082428.2 ENSMUST00000082428.3 ENSMUST00000082428.4 ENSMUST00000082428.5 NM_009266 P97364 Q3TGI4 Q80ZY9 SPS2_MOUSE Sps2 uc009jux.1 uc009jux.2 uc009jux.3 uc009jux.4 This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. [provided by RefSeq, May 2017]. ##Evidence-Data-START## Transcript is intronless :: U43285.1, BC016508.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 8986768 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Synthesizes selenophosphate from selenide and ATP. Reaction=ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate; Xref=Rhea:RHEA:18737, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16144, ChEBI:CHEBI:29317, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; EC=2.7.9.3; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Homodimer. Truncated SEPHS2 proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC3) complex, which recognizes the glycine (Gly) at the C-terminus of truncated SEPHS2 proteins. Belongs to the selenophosphate synthase 1 family. Class I subfamily. nucleotide binding selenium compound metabolic process selenide, water dikinase activity ATP binding cytoplasm selenocysteine biosynthetic process kinase activity phosphorylation transferase activity tRNA seleno-modification uc009jux.1 uc009jux.2 uc009jux.3 uc009jux.4 
ENSMUST00000082429.8 Gpx1 ENSMUST00000082429.8 glutathione peroxidase 1, transcript variant 1 (from RefSeq NM_008160.6) ENSMUST00000082429.1 ENSMUST00000082429.2 ENSMUST00000082429.3 ENSMUST00000082429.4 ENSMUST00000082429.5 ENSMUST00000082429.6 ENSMUST00000082429.7 GPX1_MOUSE Gpx1 NM_008160 P11352 P12079 Q544W3 Q5RJH8 Q9CR54 uc009rpf.1 uc009rpf.2 uc009rpf.3 uc009rpf.4 uc009rpf.5 uc009rpf.6 The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Knockout mice lacking this gene are highly sensitive to oxidants, and develop mature cataracts due to damage to the eye lens nucleus. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]. Catalyzes the reduction of hydroperoxides in a glutathione- dependent manner thus regulating cellular redox homeostasis (PubMed:9126277, PubMed:9195979, PubMed:9712879, PubMed:10754271, PubMed:21420488, PubMed:36608588). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:9126277, PubMed:9195979, PubMed:9712879, PubMed:10754271, PubMed:21420488, PubMed:36608588). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:9195979). Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16834; Evidence=; Reaction=a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O; Xref=Rhea:RHEA:19057, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:131871, ChEBI:CHEBI:134019; EC=1.11.1.12; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19058; Evidence=; Reaction=2 glutathione + tert-butyl hydroperoxide = glutathione disulfide + H2O + tert-butanol; Xref=Rhea:RHEA:69412, ChEBI:CHEBI:15377, ChEBI:CHEBI:45895, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:64090; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69413; Evidence=; Reaction=cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O; Xref=Rhea:RHEA:69651, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:78673, ChEBI:CHEBI:131607; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69652; Evidence=; Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48888, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90850; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48889; Evidence=; Reaction=(9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76687, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:60955, ChEBI:CHEBI:77852; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76688; Evidence=; Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48620, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90632; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48621; Evidence=; Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:50708, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90680; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50709; Evidence=; Reaction=(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76691, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:75230, ChEBI:CHEBI:83343; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76692; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76695, ChEBI:CHEBI:15377, ChEBI:CHEBI:57409, ChEBI:CHEBI:57446, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76696; Evidence=; Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76699, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:195399, ChEBI:CHEBI:195400; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76700; Evidence=; Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76703, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90772, ChEBI:CHEBI:195401; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76704; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76707, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:132087, ChEBI:CHEBI:194369; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76708; Evidence=; Reaction=(15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76711, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:144832, ChEBI:CHEBI:195402; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76712; Evidence=; Reaction=(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76715, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:133795, ChEBI:CHEBI:195403; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76716; Evidence=; Kinetic parameters: KM=14 uM for H(2)O(2) (at 25 degrees Celsius, in 0.1 M phosphate buffer, pH 7.0) ; KM=29 uM for tert-butylperoxide (at 25 degrees Celsius, in 0.1 M phosphate buffer, pH 7.0) ; Vmax=319 mM/min/mg enzyme toward H(2)O(2) (at 25 degrees Celsius, in 0.1 M phosphate buffer, pH 7.0) ; Vmax=182 mM/min/mg enzyme toward tert-butylperoxide (at 25 degrees Celsius, in 0.1 M phosphate buffer, pH 7.0) ; Homotetramer. Interacts with MIEN1. Cytoplasm tochondrion Expressed in liver, kidney, lung, brain and heart. During periods of oxidative stress, Sec-47 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine. Mutants are healthy, fertile and show no increased sensitivity to hyperoxia (PubMed:9195979). Mice display enhanced susceptibility to paraquat and cortical neurons from Gpx1- deficient mice are more susceptible to H2O2-mediated toxicity than neurons from wild-type mice (PubMed:9712879). Gpx1-deficient mice are smaller than wild type littermates and the liver has increased mitochondrial H2O2 production, increased lipid peroxides, and decreased mitochondrial energy output (PubMed:10754271). In the absence of Sod1, Gpx1 in the liver undergoes a 40% reduction in catalytic activity as a result of the decomposition of Sec-47 to dehydroalanine. Belongs to the glutathione peroxidase family. PubMed:2771650 sequence was originally thought to originate from human. Sequence=CAB43535.1; Type=Miscellaneous discrepancy; Note=Number of sequencing artifacts.; Evidence=; response to reactive oxygen species temperature homeostasis endothelial cell development negative regulation of inflammatory response to antigenic stimulus peroxidase activity glutathione peroxidase activity protein binding nucleus cytoplasm mitochondrion cytosol lipid metabolic process triglyceride metabolic process glutathione metabolic process response to oxidative stress sensory perception of sound cell proliferation response to xenobiotic stimulus response to symbiotic bacterium response to wounding response to toxic substance UV protection response to selenium ion response to gamma radiation myotube differentiation oxidoreductase activity SH3 domain binding protein oxidation response to hydroperoxide regulation of mammary gland epithelial cell proliferation regulation of gene expression, epigenetic vasodilation response to hydrogen peroxide hydrogen peroxide catabolic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process skeletal muscle tissue regeneration blood vessel endothelial cell migration fat cell differentiation cell redox homeostasis skeletal muscle fiber development myoblast proliferation interaction with symbiont positive regulation of protein kinase B signaling oxidation-reduction process heart contraction angiogenesis involved in wound healing regulation of proteasomal protein catabolic process cellular response to glucose stimulus negative regulation of release of cytochrome c from mitochondria Lewy body cellular oxidant detoxification negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway uc009rpf.1 uc009rpf.2 uc009rpf.3 uc009rpf.4 uc009rpf.5 uc009rpf.6 
ENSMUST00000082430.11 Gpx3 ENSMUST00000082430.11 glutathione peroxidase 3, transcript variant 1 (from RefSeq NM_008161.4) ENSMUST00000082430.1 ENSMUST00000082430.10 ENSMUST00000082430.2 ENSMUST00000082430.3 ENSMUST00000082430.4 ENSMUST00000082430.5 ENSMUST00000082430.6 ENSMUST00000082430.7 ENSMUST00000082430.8 ENSMUST00000082430.9 GPX3_MOUSE Gpx3 NM_008161 P46412 Q5XKR0 uc007iyk.1 uc007iyk.2 uc007iyk.3 uc007iyk.4 The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted and is highly expressed in mouse kidney, which appears to be the major source of the enzyme in plasma. It has a role in mouse organogenesis, and dysregulation of this isozyme has been associated with obesity-related metabolic complications, platelet-dependent thrombosis, colitis-associated carcinoma, and thermosensitive phenotype. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2016]. Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; Evidence=; Reaction=2 glutathione + tert-butyl hydroperoxide = glutathione disulfide + H2O + tert-butanol; Xref=Rhea:RHEA:69412, ChEBI:CHEBI:15377, ChEBI:CHEBI:45895, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:64090; Evidence=; Homotetramer. Secreted. Secreted in plasma. Belongs to the glutathione peroxidase family. peroxidase activity glutathione peroxidase activity extracellular region extracellular space glutathione metabolic process response to oxidative stress selenium binding oxidoreductase activity hydrogen peroxide catabolic process protein homotetramerization oxidation-reduction process cellular oxidant detoxification uc007iyk.1 uc007iyk.2 uc007iyk.3 uc007iyk.4 
ENSMUST00000082431.6 Gpx2 ENSMUST00000082431.6 glutathione peroxidase 2 (from RefSeq NM_030677.2) A0A0R4J111 A0A0R4J111_MOUSE ENSMUST00000082431.1 ENSMUST00000082431.2 ENSMUST00000082431.3 ENSMUST00000082431.4 ENSMUST00000082431.5 Gpx2 NM_030677 uc007nys.1 uc007nys.2 The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract in rodents, is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Knockout studies in mice lacking this gene suggest a role for this isozyme in intestinal inflammation and colon cancer development. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 7. [provided by RefSeq, Aug 2017]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK131940.1, BC039658.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9637305 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16834; Evidence=; Reaction=2 glutathione + tert-butyl hydroperoxide = glutathione disulfide + H2O + tert-butanol; Xref=Rhea:RHEA:69412, ChEBI:CHEBI:15377, ChEBI:CHEBI:45895, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:64090; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69413; Evidence=; Reaction=a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O; Xref=Rhea:RHEA:62632, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62633; Evidence=; Reaction=cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O; Xref=Rhea:RHEA:69651, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:78673, ChEBI:CHEBI:131607; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69652; Evidence=; Homotetramer. Cytoplasm, cytosol Belongs to the glutathione peroxidase family. peroxidase activity glutathione peroxidase activity response to oxidative stress oxidoreductase activity oxidation-reduction process cellular oxidant detoxification uc007nys.1 uc007nys.2 
ENSMUST00000082432.7 Dio2 ENSMUST00000082432.7 deiodinase, iodothyronine, type II (from RefSeq NM_010050.4) A0A8Z1S5Q0 A0A8Z1S5Q0_MOUSE Dio2 ENSMUST00000082432.1 ENSMUST00000082432.2 ENSMUST00000082432.3 ENSMUST00000082432.4 ENSMUST00000082432.5 ENSMUST00000082432.6 NM_010050 uc007okf.1 uc007okf.2 uc007okf.3 uc007okf.4 uc007okf.5 The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is highly expressed in brain, placenta and mammary gland. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. Knockout studies in mice suggest that this gene may play an important role in brown adipose tissue lipogenesis, auditory function, and bone formation. This protein is a selenoprotein containing the non-standard amino acid, selenocysteine (Sec), which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Unlike the other two members (DIO1 and DIO3) of this enzyme family, the mRNA for this gene contains an additional in-frame UGA codon that has been reported (in human) to function either as a Sec or a stop codon, resulting in two potential isoforms with one or two Sec residues; however, only the upstream Sec (conserved with the single Sec residue found at the active site in DIO1 and DIO3) was shown to be essential for enzyme activity (PMID:10403186). In addition, the lack of conservation of the protein extension past the second TGA codon suggests that the one-Sec containing isoform represents the canonical form. [provided by RefSeq, Oct 2018]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF096875.1, SRR1660815.138267.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9927339 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). Interacts with USP20 and USP33. Interacts with MARCHF6. Belongs to the iodothyronine deiodinase family. uc007okf.1 uc007okf.2 uc007okf.3 uc007okf.4 uc007okf.5 
ENSMUST00000082437.11 Selenof ENSMUST00000082437.11 selenoprotein F (from RefSeq NM_053102.2) A0A0R4J0K1 A0A0R4J0K1_MOUSE ENSMUST00000082437.1 ENSMUST00000082437.10 ENSMUST00000082437.2 ENSMUST00000082437.3 ENSMUST00000082437.4 ENSMUST00000082437.5 ENSMUST00000082437.6 ENSMUST00000082437.7 ENSMUST00000082437.8 ENSMUST00000082437.9 NM_053102 Selenof Sep15 uc008rpr.1 uc008rpr.2 uc008rpr.3 uc008rpr.4 The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. Knockout studies in mice also suggest a role for this gene in cataract formation and colon carcinogenesis. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Nov 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF288740.1, AK159085.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 10945981 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Belongs to the selenoprotein M/F family. endoplasmic reticulum lumen uc008rpr.1 uc008rpr.2 uc008rpr.3 uc008rpr.4 
ENSMUST00000082439.6 Selenoo ENSMUST00000082439.6 selenoprotein O (from RefSeq NM_027905.3) E9QPP4 ENSMUST00000082439.1 ENSMUST00000082439.2 ENSMUST00000082439.3 ENSMUST00000082439.4 ENSMUST00000082439.5 NM_027905 Q80ZK3 Q9DBC0 SELO_MOUSE Selenoo Selo uc007xff.1 uc007xff.2 uc007xff.3 This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Jan 2017]. ##Evidence-Data-START## Transcript exon combination :: BC141293.1, AK005048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology protein contains selenocysteine :: inferred from conservation RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein. Reaction=ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L- tyrosyl-[protein]; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108; Evidence=; Reaction=ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl- [protein] + diphosphate; Xref=Rhea:RHEA:54292, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13847, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:138113; EC=2.7.7.108; Evidence=; Reaction=ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate; Xref=Rhea:RHEA:58120, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:15073, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:142516; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Mitochondrion Belongs to the SELO family. Sequence=AAH48849.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAB23774.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; nucleotide binding ATP binding mitochondrion transferase activity nucleotidyltransferase activity protein adenylylation metal ion binding protein adenylyltransferase activity uc007xff.1 uc007xff.2 uc007xff.3 
ENSMUST00000082443.3 Gm24966 ENSMUST00000082443.3 Gm24966 (from geneSymbol) ENSMUST00000082443.1 ENSMUST00000082443.2 uc291qnj.1 uc291qnj.2 uc291qnj.1 uc291qnj.2 
ENSMUST00000082446.3 Gm26448 ENSMUST00000082446.3 Gm26448 (from geneSymbol) ENSMUST00000082446.1 ENSMUST00000082446.2 uc292mev.1 uc292mev.2 uc292mev.1 uc292mev.2 
ENSMUST00000082448.3 Gm26447 ENSMUST00000082448.3 Gm26447 (from geneSymbol) ENSMUST00000082448.1 ENSMUST00000082448.2 uc289dto.1 uc289dto.2 uc289dto.1 uc289dto.2 
ENSMUST00000082452.4 Gm26449 ENSMUST00000082452.4 Gm26449 (from geneSymbol) ENSMUST00000082452.1 ENSMUST00000082452.2 ENSMUST00000082452.3 uc288ezz.1 uc288ezz.2 uc288ezz.1 uc288ezz.2 
ENSMUST00000082453.3 Snora73a ENSMUST00000082453.3 small nucleolar RNA, H/ACA box 73a (from RefSeq NR_028512.1) ENSMUST00000082453.1 ENSMUST00000082453.2 NR_028512 uc057lkh.1 uc057lkh.2 uc057lkh.1 uc057lkh.2 
ENSMUST00000082455.3 Gm26446 ENSMUST00000082455.3 Gm26446 (from geneSymbol) ENSMUST00000082455.1 ENSMUST00000082455.2 uc287kot.1 uc287kot.2 uc287kot.1 uc287kot.2 
ENSMUST00000082456.3 Snord73b ENSMUST00000082456.3 small nucleolar RNA, C/D box U73B (from RefSeq NR_004418.2) ENSMUST00000082456.1 ENSMUST00000082456.2 NR_004418 uc012crc.1 uc012crc.2 uc012crc.3 uc012crc.1 uc012crc.2 uc012crc.3 
ENSMUST00000082457.4 Gm23625 ENSMUST00000082457.4 Gm23625 (from geneSymbol) ENSMUST00000082457.1 ENSMUST00000082457.2 ENSMUST00000082457.3 uc291fci.1 uc291fci.2 uc291fci.1 uc291fci.2 
ENSMUST00000082458.3 Gm23626 ENSMUST00000082458.3 Gm23626 (from geneSymbol) ENSMUST00000082458.1 ENSMUST00000082458.2 uc292bnm.1 uc292bnm.2 uc292bnm.1 uc292bnm.2 
ENSMUST00000082460.3 Gm23622 ENSMUST00000082460.3 Gm23622 (from geneSymbol) DQ558729 ENSMUST00000082460.1 ENSMUST00000082460.2 uc288vsj.1 uc288vsj.2 uc288vsj.1 uc288vsj.2 
ENSMUST00000082461.3 Gm23623 ENSMUST00000082461.3 Gm23623 (from geneSymbol) DQ558729 ENSMUST00000082461.1 ENSMUST00000082461.2 uc287lmx.1 uc287lmx.2 uc287lmx.1 uc287lmx.2 
ENSMUST00000082464.3 Gm23628 ENSMUST00000082464.3 Gm23628 (from geneSymbol) ENSMUST00000082464.1 ENSMUST00000082464.2 uc292nkk.1 uc292nkk.2 uc292nkk.1 uc292nkk.2 
ENSMUST00000082465.3 Gm23629 ENSMUST00000082465.3 Gm23629 (from geneSymbol) DQ558729 ENSMUST00000082465.1 ENSMUST00000082465.2 uc288vcq.1 uc288vcq.2 uc288vcq.1 uc288vcq.2 
ENSMUST00000082466.4 Snord3b-ps1 ENSMUST00000082466.4 Snord3b-ps1 (from geneSymbol) ENSMUST00000082466.1 ENSMUST00000082466.2 ENSMUST00000082466.3 uc289pzw.1 uc289pzw.2 uc289pzw.1 uc289pzw.2 
ENSMUST00000082469.4 Gm23928 ENSMUST00000082469.4 Gm23928 (from geneSymbol) ENSMUST00000082469.1 ENSMUST00000082469.2 ENSMUST00000082469.3 uc291sqi.1 uc291sqi.2 uc291sqi.1 uc291sqi.2 
ENSMUST00000082471.3 Gm23925 ENSMUST00000082471.3 Gm23925 (from geneSymbol) ENSMUST00000082471.1 ENSMUST00000082471.2 uc290cdc.1 uc290cdc.2 uc290cdc.1 uc290cdc.2 
ENSMUST00000082473.4 Gm23926 ENSMUST00000082473.4 Gm23926 (from geneSymbol) DQ558729 ENSMUST00000082473.1 ENSMUST00000082473.2 ENSMUST00000082473.3 uc288vyv.1 uc288vyv.2 uc288vyv.1 uc288vyv.2 
ENSMUST00000082474.3 Gm23924 ENSMUST00000082474.3 Gm23924 (from geneSymbol) DQ558729 ENSMUST00000082474.1 ENSMUST00000082474.2 uc291fxc.1 uc291fxc.2 uc291fxc.1 uc291fxc.2 
ENSMUST00000082476.2 Gm22247 ENSMUST00000082476.2 Gm22247 (from geneSymbol) ENSMUST00000082476.1 uc290mof.1 uc290mof.2 uc290mof.1 uc290mof.2 
ENSMUST00000082479.4 Gm22245 ENSMUST00000082479.4 Gm22245 (from geneSymbol) ENSMUST00000082479.1 ENSMUST00000082479.2 ENSMUST00000082479.3 uc290asz.1 uc290asz.2 uc290asz.1 uc290asz.2 
ENSMUST00000082482.3 Gm22248 ENSMUST00000082482.3 Gm22248 (from geneSymbol) ENSMUST00000082482.1 ENSMUST00000082482.2 uc292rei.1 uc292rei.2 uc292rei.1 uc292rei.2 
ENSMUST00000082483.3 DQ267102 ENSMUST00000082483.3 snoRNA DQ267102 (from RefSeq NR_046306.1) ENSMUST00000082483.1 ENSMUST00000082483.2 NR_046306 uc029rya.1 uc029rya.2 uc029rya.3 uc029rya.1 uc029rya.2 uc029rya.3 
ENSMUST00000082485.3 Gm22249 ENSMUST00000082485.3 Gm22249 (from geneSymbol) ENSMUST00000082485.1 ENSMUST00000082485.2 uc290vbk.1 uc290vbk.2 uc290vbk.1 uc290vbk.2 
ENSMUST00000082487.3 Gm23140 ENSMUST00000082487.3 Gm23140 (from geneSymbol) ENSMUST00000082487.1 ENSMUST00000082487.2 uc289shm.1 uc289shm.2 uc289shm.1 uc289shm.2 
ENSMUST00000082488.3 Gm22502 ENSMUST00000082488.3 Gm22502 (from geneSymbol) DQ558729 ENSMUST00000082488.1 ENSMUST00000082488.2 uc290djy.1 uc290djy.2 uc290djy.1 uc290djy.2 
ENSMUST00000082493.3 Gm22748 ENSMUST00000082493.3 Gm22748 (from geneSymbol) ENSMUST00000082493.1 ENSMUST00000082493.2 uc288fdk.1 uc288fdk.2 uc288fdk.1 uc288fdk.2 
ENSMUST00000082494.3 Gm22746 ENSMUST00000082494.3 Gm22746 (from geneSymbol) ENSMUST00000082494.1 ENSMUST00000082494.2 uc292rqe.1 uc292rqe.2 uc292rqe.1 uc292rqe.2 
ENSMUST00000082498.3 Gm25587 ENSMUST00000082498.3 Gm25587 (from geneSymbol) ENSMUST00000082498.1 ENSMUST00000082498.2 uc287uqt.1 uc287uqt.2 uc287uqt.1 uc287uqt.2 
ENSMUST00000082501.3 Gm25588 ENSMUST00000082501.3 Gm25588 (from geneSymbol) ENSMUST00000082501.1 ENSMUST00000082501.2 uc287mqd.1 uc287mqd.2 uc287mqd.1 uc287mqd.2 
ENSMUST00000082502.3 Gm25589 ENSMUST00000082502.3 Gm25589 (from geneSymbol) ENSMUST00000082502.1 ENSMUST00000082502.2 uc291czw.1 uc291czw.2 uc291czw.1 uc291czw.2 
ENSMUST00000082503.4 Snord49b ENSMUST00000082503.4 small nucleolar RNA, C/D box 49B (from RefSeq NR_028526.1) ENSMUST00000082503.1 ENSMUST00000082503.2 ENSMUST00000082503.3 NR_028526 uc011xwc.1 uc011xwc.2 uc011xwc.3 uc011xwc.1 uc011xwc.2 uc011xwc.3 
ENSMUST00000082506.3 Gm26224 ENSMUST00000082506.3 Gm26224 (from geneSymbol) ENSMUST00000082506.1 ENSMUST00000082506.2 uc287nby.1 uc287nby.2 uc287nby.1 uc287nby.2 
ENSMUST00000082507.3 Snord37 ENSMUST00000082507.3 small nucleolar RNA, C/D box 37 (from RefSeq NR_028549.1) ENSMUST00000082507.1 ENSMUST00000082507.2 NR_028549 uc011xjd.1 uc011xjd.2 uc011xjd.3 uc011xjd.1 uc011xjd.2 uc011xjd.3 
ENSMUST00000082508.3 Gm26225 ENSMUST00000082508.3 Gm26225 (from geneSymbol) ENSMUST00000082508.1 ENSMUST00000082508.2 uc288ven.1 uc288ven.2 uc288ven.1 uc288ven.2 
ENSMUST00000082509.3 Gm26226 ENSMUST00000082509.3 Gm26226 (from geneSymbol) DQ558729 ENSMUST00000082509.1 ENSMUST00000082509.2 uc290rgr.1 uc290rgr.2 uc290rgr.1 uc290rgr.2 
ENSMUST00000082510.3 Gm26227 ENSMUST00000082510.3 Gm26227 (from geneSymbol) ENSMUST00000082510.1 ENSMUST00000082510.2 uc290aux.1 uc290aux.2 uc290aux.1 uc290aux.2 
ENSMUST00000082512.3 Gm26228 ENSMUST00000082512.3 Gm26228 (from geneSymbol) DQ558729 ENSMUST00000082512.1 ENSMUST00000082512.2 uc288sik.1 uc288sik.2 uc288sik.1 uc288sik.2 
ENSMUST00000082516.3 Snord68 ENSMUST00000082516.3 small nucleolar RNA, C/D box 68 (from RefSeq NR_028128.1) ENSMUST00000082516.1 ENSMUST00000082516.2 NR_028128 uc292dve.1 uc292dve.2 uc292dve.1 uc292dve.2 
ENSMUST00000082517.3 Snora23 ENSMUST00000082517.3 small nucleolar RNA, H/ACA box 23 (from RefSeq NR_033336.2) ENSMUST00000082517.1 ENSMUST00000082517.2 NR_033336 uc012fsd.1 uc012fsd.2 uc012fsd.1 uc012fsd.2 
ENSMUST00000082518.3 Gm24564 ENSMUST00000082518.3 Gm24564 (from geneSymbol) ENSMUST00000082518.1 ENSMUST00000082518.2 LF199329 uc288jdw.1 uc288jdw.2 uc288jdw.1 uc288jdw.2 
ENSMUST00000082519.3 Snord21 ENSMUST00000082519.3 Snord21 (from geneSymbol) DQ549760 ENSMUST00000082519.1 ENSMUST00000082519.2 uc290xxd.1 uc290xxd.2 uc290xxd.1 uc290xxd.2 
ENSMUST00000082526.3 Gm25080 ENSMUST00000082526.3 Gm25080 (from geneSymbol) DQ558729 ENSMUST00000082526.1 ENSMUST00000082526.2 uc290jzx.1 uc290jzx.2 uc290jzx.1 uc290jzx.2 
ENSMUST00000082529.3 Gm25079 ENSMUST00000082529.3 Gm25079 (from geneSymbol) ENSMUST00000082529.1 ENSMUST00000082529.2 uc289eiw.1 uc289eiw.2 uc289eiw.1 uc289eiw.2 
ENSMUST00000082530.3 Gm25078 ENSMUST00000082530.3 Gm25078 (from geneSymbol) ENSMUST00000082530.1 ENSMUST00000082530.2 uc292nzg.1 uc292nzg.2 uc292nzg.1 uc292nzg.2 
ENSMUST00000082534.4 Gm25081 ENSMUST00000082534.4 Gm25081 (from geneSymbol) ENSMUST00000082534.1 ENSMUST00000082534.2 ENSMUST00000082534.3 uc289vta.1 uc289vta.2 uc289vta.1 uc289vta.2 
ENSMUST00000082537.3 Gm23406 ENSMUST00000082537.3 Gm23406 (from geneSymbol) ENSMUST00000082537.1 ENSMUST00000082537.2 uc289fxm.1 uc289fxm.2 uc289fxm.1 uc289fxm.2 
ENSMUST00000082538.3 Gm23407 ENSMUST00000082538.3 Gm23407 (from geneSymbol) ENSMUST00000082538.1 ENSMUST00000082538.2 uc292hks.1 uc292hks.2 uc292hks.1 uc292hks.2 
ENSMUST00000082542.4 Gm23405 ENSMUST00000082542.4 Gm23405 (from geneSymbol) ENSMUST00000082542.1 ENSMUST00000082542.2 ENSMUST00000082542.3 uc290sbs.1 uc290sbs.2 uc290sbs.1 uc290sbs.2 
ENSMUST00000082543.3 Gm23404 ENSMUST00000082543.3 Gm23404 (from geneSymbol) ENSMUST00000082543.1 ENSMUST00000082543.2 uc292rkb.1 uc292rkb.2 uc292rkb.1 uc292rkb.2 
ENSMUST00000082547.3 Gm23737 ENSMUST00000082547.3 Gm23737 (from geneSymbol) ENSMUST00000082547.1 ENSMUST00000082547.2 uc289and.1 uc289and.2 uc289and.1 uc289and.2 
ENSMUST00000082550.3 Gm23711 ENSMUST00000082550.3 Gm23711 (from geneSymbol) ENSMUST00000082550.1 ENSMUST00000082550.2 uc290qhe.1 uc290qhe.2 uc290qhe.1 uc290qhe.2 
ENSMUST00000082551.3 Gm23735 ENSMUST00000082551.3 Gm23735 (from geneSymbol) ENSMUST00000082551.1 ENSMUST00000082551.2 uc288voh.1 uc288voh.2 uc288voh.1 uc288voh.2 
ENSMUST00000082552.4 Gm23293 ENSMUST00000082552.4 Gm23293 (from geneSymbol) ENSMUST00000082552.1 ENSMUST00000082552.2 ENSMUST00000082552.3 LF198710 uc288aqw.1 uc288aqw.2 uc288aqw.1 uc288aqw.2 
ENSMUST00000082553.3 Gm23736 ENSMUST00000082553.3 Gm23736 (from geneSymbol) ENSMUST00000082553.1 ENSMUST00000082553.2 uc288jet.1 uc288jet.2 uc288jet.1 uc288jet.2 
ENSMUST00000082556.3 Gm22283 ENSMUST00000082556.3 Gm22283 (from geneSymbol) ENSMUST00000082556.1 ENSMUST00000082556.2 uc291fxm.1 uc291fxm.2 uc291fxm.1 uc291fxm.2 
ENSMUST00000082558.3 Gm22060 ENSMUST00000082558.3 Gm22060 (from geneSymbol) DQ558729 ENSMUST00000082558.1 ENSMUST00000082558.2 uc292fnu.1 uc292fnu.2 uc292fnu.1 uc292fnu.2 
ENSMUST00000082559.3 Snora28 ENSMUST00000082559.3 small nucleolar RNA, H/ACA box 28 (from RefSeq NR_033168.1) ENSMUST00000082559.1 ENSMUST00000082559.2 NR_033168 uc288jki.1 uc288jki.2 uc288jki.1 uc288jki.2 
ENSMUST00000082561.3 Gm24313 ENSMUST00000082561.3 Gm24313 (from geneSymbol) ENSMUST00000082561.1 ENSMUST00000082561.2 uc287woe.1 uc287woe.2 uc287woe.1 uc287woe.2 
ENSMUST00000082562.3 DQ267101 ENSMUST00000082562.3 snoRNA DQ267101 (from RefSeq NR_046305.1) ENSMUST00000082562.1 ENSMUST00000082562.2 NR_046305 uc288jem.1 uc288jem.2 uc288jem.1 uc288jem.2 
ENSMUST00000082563.3 Gm22062 ENSMUST00000082563.3 Gm22062 (from geneSymbol) DQ558729 ENSMUST00000082563.1 ENSMUST00000082563.2 uc292rsb.1 uc292rsb.2 uc292rsb.1 uc292rsb.2 
ENSMUST00000082566.4 Gm25296 ENSMUST00000082566.4 Gm25296 (from geneSymbol) AK163811 ENSMUST00000082566.1 ENSMUST00000082566.2 ENSMUST00000082566.3 uc287xqz.1 uc287xqz.2 uc287xqz.1 uc287xqz.2 
ENSMUST00000082570.4 Gm23570 ENSMUST00000082570.4 Gm23570 (from geneSymbol) ENSMUST00000082570.1 ENSMUST00000082570.2 ENSMUST00000082570.3 uc291bpb.1 uc291bpb.2 uc291bpb.1 uc291bpb.2 
ENSMUST00000082576.4 Gm22458 ENSMUST00000082576.4 Gm22458 (from geneSymbol) ENSMUST00000082576.1 ENSMUST00000082576.2 ENSMUST00000082576.3 uc290kve.1 uc290kve.2 uc290kve.1 uc290kve.2 
ENSMUST00000082577.3 Gm22459 ENSMUST00000082577.3 Gm22459 (from geneSymbol) ENSMUST00000082577.1 ENSMUST00000082577.2 uc289faj.1 uc289faj.2 uc289faj.1 uc289faj.2 
ENSMUST00000082578.4 Gm22456 ENSMUST00000082578.4 Gm22456 (from geneSymbol) ENSMUST00000082578.1 ENSMUST00000082578.2 ENSMUST00000082578.3 uc288bnh.1 uc288bnh.2 uc288bnh.1 uc288bnh.2 
ENSMUST00000082579.3 Snora9 ENSMUST00000082579.3 Snora9 (from geneSymbol) ENSMUST00000082579.1 ENSMUST00000082579.2 uc287wnq.1 uc287wnq.2 uc287wnq.1 uc287wnq.2 
ENSMUST00000082580.3 Gm22455 ENSMUST00000082580.3 Gm22455 (from geneSymbol) ENSMUST00000082580.1 ENSMUST00000082580.2 uc292icg.1 uc292icg.2 uc292icg.1 uc292icg.2 
ENSMUST00000082581.3 n-R5s162 ENSMUST00000082581.3 n-R5s162 (from geneSymbol) ENSMUST00000082581.1 ENSMUST00000082581.2 uc291eym.1 uc291eym.2 uc291eym.1 uc291eym.2 
ENSMUST00000082583.3 Gm22454 ENSMUST00000082583.3 Gm22454 (from geneSymbol) ENSMUST00000082583.1 ENSMUST00000082583.2 uc292kso.1 uc292kso.2 uc292kso.1 uc292kso.2 
ENSMUST00000082588.3 Gm26442 ENSMUST00000082588.3 Gm26442 (from geneSymbol) ENSMUST00000082588.1 ENSMUST00000082588.2 uc290ftm.1 uc290ftm.2 uc290ftm.1 uc290ftm.2 
ENSMUST00000082590.3 Gm26441 ENSMUST00000082590.3 Gm26441 (from geneSymbol) ENSMUST00000082590.1 ENSMUST00000082590.2 uc292red.1 uc292red.2 uc292red.1 uc292red.2 
ENSMUST00000082591.3 Gm26440 ENSMUST00000082591.3 Gm26440 (from geneSymbol) ENSMUST00000082591.1 ENSMUST00000082591.2 uc288uvp.1 uc288uvp.2 uc288uvp.1 uc288uvp.2 
ENSMUST00000082592.3 Gm26439 ENSMUST00000082592.3 Gm26439 (from geneSymbol) ENSMUST00000082592.1 ENSMUST00000082592.2 uc288bcg.1 uc288bcg.2 uc288bcg.1 uc288bcg.2 
ENSMUST00000082593.4 Gm26438 ENSMUST00000082593.4 Gm26438 (from geneSymbol) ENSMUST00000082593.1 ENSMUST00000082593.2 ENSMUST00000082593.3 uc289ppf.1 uc289ppf.2 uc289ppf.1 uc289ppf.2 
ENSMUST00000082595.3 Gm26437 ENSMUST00000082595.3 Gm26437 (from geneSymbol) ENSMUST00000082595.1 ENSMUST00000082595.2 uc292nwa.1 uc292nwa.2 uc292nwa.1 uc292nwa.2 
ENSMUST00000082596.4 Gm23613 ENSMUST00000082596.4 Gm23613 (from geneSymbol) ENSMUST00000082596.1 ENSMUST00000082596.2 ENSMUST00000082596.3 uc292nsf.1 uc292nsf.2 uc292nsf.1 uc292nsf.2 
ENSMUST00000082598.3 Gm23614 ENSMUST00000082598.3 Gm23614 (from geneSymbol) ENSMUST00000082598.1 ENSMUST00000082598.2 uc291vef.1 uc291vef.2 uc291vef.1 uc291vef.2 
ENSMUST00000082602.3 Gm23615 ENSMUST00000082602.3 Gm23615 (from geneSymbol) ENSMUST00000082602.1 ENSMUST00000082602.2 LF202050 uc292osv.1 uc292osv.2 uc292osv.1 uc292osv.2 
ENSMUST00000082606.3 Snord42a ENSMUST00000082606.3 small nucleolar RNA, C/D box 42A (from RefSeq NR_037682.1) ENSMUST00000082606.1 ENSMUST00000082606.2 NR_037682 uc011yaf.1 uc011yaf.2 uc011yaf.3 uc011yaf.1 uc011yaf.2 uc011yaf.3 
ENSMUST00000082607.3 Gm22978 ENSMUST00000082607.3 Gm22978 (from geneSymbol) ENSMUST00000082607.1 ENSMUST00000082607.2 uc289lua.1 uc289lua.2 uc289lua.1 uc289lua.2 
ENSMUST00000082608.3 Gm22980 ENSMUST00000082608.3 Gm22980 (from geneSymbol) DQ694433 ENSMUST00000082608.1 ENSMUST00000082608.2 uc290pcn.1 uc290pcn.2 uc290pcn.1 uc290pcn.2 
ENSMUST00000082609.3 Gm22979 ENSMUST00000082609.3 Gm22979 (from geneSymbol) ENSMUST00000082609.1 ENSMUST00000082609.2 uc288xoi.1 uc288xoi.2 uc288xoi.1 uc288xoi.2 
ENSMUST00000082611.4 Gm22981 ENSMUST00000082611.4 Gm22981 (from geneSymbol) ENSMUST00000082611.1 ENSMUST00000082611.2 ENSMUST00000082611.3 uc288jev.1 uc288jev.2 uc288jev.1 uc288jev.2 
ENSMUST00000082614.3 n-R5s65 ENSMUST00000082614.3 n-R5s65 (from geneSymbol) ENSMUST00000082614.1 ENSMUST00000082614.2 uc288iij.1 uc288iij.2 uc288iij.1 uc288iij.2 
ENSMUST00000082615.3 Gm22977 ENSMUST00000082615.3 Gm22977 (from geneSymbol) DQ558729 ENSMUST00000082615.1 ENSMUST00000082615.2 uc289fat.1 uc289fat.2 uc289fat.1 uc289fat.2 
ENSMUST00000082616.3 Gm24623 ENSMUST00000082616.3 Gm24623 (from geneSymbol) ENSMUST00000082616.1 ENSMUST00000082616.2 uc290xib.1 uc290xib.2 uc290xib.1 uc290xib.2 
ENSMUST00000082617.3 Gm24624 ENSMUST00000082617.3 Gm24624 (from geneSymbol) ENSMUST00000082617.1 ENSMUST00000082617.2 uc292qge.1 uc292qge.2 uc292qge.1 uc292qge.2 
ENSMUST00000082619.4 Gm24622 ENSMUST00000082619.4 Gm24622 (from geneSymbol) ENSMUST00000082619.1 ENSMUST00000082619.2 ENSMUST00000082619.3 uc292qbg.1 uc292qbg.2 uc292qbg.1 uc292qbg.2 
ENSMUST00000082620.3 n-R5s173 ENSMUST00000082620.3 n-R5s173 (from geneSymbol) ENSMUST00000082620.1 ENSMUST00000082620.2 uc290xvl.1 uc290xvl.2 uc290xvl.1 uc290xvl.2 
ENSMUST00000082621.3 Gm24626 ENSMUST00000082621.3 Gm24626 (from geneSymbol) ENSMUST00000082621.1 ENSMUST00000082621.2 uc290wsq.1 uc290wsq.2 uc290wsq.1 uc290wsq.2 
ENSMUST00000082622.3 Gm24625 ENSMUST00000082622.3 Gm24625 (from geneSymbol) ENSMUST00000082622.1 ENSMUST00000082622.2 uc288vbt.1 uc288vbt.2 uc288vbt.1 uc288vbt.2 
ENSMUST00000082624.3 Gm24620 ENSMUST00000082624.3 Gm24620 (from geneSymbol) ENSMUST00000082624.1 ENSMUST00000082624.2 uc288mor.1 uc288mor.2 uc288mor.1 uc288mor.2 
ENSMUST00000082629.3 Snora7a ENSMUST00000082629.3 small nucleolar RNA, H/ACA box 7A (from RefSeq NR_028546.1) ENSMUST00000082629.1 ENSMUST00000082629.2 NR_028546 uc291hzy.1 uc291hzy.2 uc291hzy.1 uc291hzy.2 
ENSMUST00000082631.3 Gm24145 ENSMUST00000082631.3 Gm24145 (from geneSymbol) AB353021 ENSMUST00000082631.1 ENSMUST00000082631.2 uc289clk.1 uc289clk.2 uc289clk.1 uc289clk.2 
ENSMUST00000082632.3 Gm24144 ENSMUST00000082632.3 Gm24144 (from geneSymbol) ENSMUST00000082632.1 ENSMUST00000082632.2 uc288wwc.1 uc288wwc.2 uc288wwc.1 uc288wwc.2 
ENSMUST00000082633.3 Gm24143 ENSMUST00000082633.3 Gm24143 (from geneSymbol) ENSMUST00000082633.1 ENSMUST00000082633.2 uc287zxg.1 uc287zxg.2 uc287zxg.1 uc287zxg.2 
ENSMUST00000082635.3 Gm25592 ENSMUST00000082635.3 Gm25592 (from geneSymbol) ENSMUST00000082635.1 ENSMUST00000082635.2 uc290iqx.1 uc290iqx.2 uc290iqx.1 uc290iqx.2 
ENSMUST00000082636.3 Gm25800 ENSMUST00000082636.3 Gm25800 (from geneSymbol) ENSMUST00000082636.1 ENSMUST00000082636.2 uc289mhn.1 uc289mhn.2 uc289mhn.1 uc289mhn.2 
ENSMUST00000082638.3 Gm25801 ENSMUST00000082638.3 Gm25801 (from geneSymbol) ENSMUST00000082638.1 ENSMUST00000082638.2 uc288iqz.1 uc288iqz.2 uc288iqz.1 uc288iqz.2 
ENSMUST00000082639.3 Gm25802 ENSMUST00000082639.3 Gm25802 (from geneSymbol) ENSMUST00000082639.1 ENSMUST00000082639.2 uc290iao.1 uc290iao.2 uc290iao.1 uc290iao.2 
ENSMUST00000082645.4 Gm25796 ENSMUST00000082645.4 Gm25796 (from geneSymbol) ENSMUST00000082645.1 ENSMUST00000082645.2 ENSMUST00000082645.3 uc290ezu.1 uc290ezu.2 uc290ezu.1 uc290ezu.2 
ENSMUST00000082646.3 Gm25134 ENSMUST00000082646.3 Gm25134 (from geneSymbol) ENSMUST00000082646.1 ENSMUST00000082646.2 LF196096 uc291mih.1 uc291mih.2 uc291mih.1 uc291mih.2 
ENSMUST00000082647.3 Gm25133 ENSMUST00000082647.3 Gm25133 (from geneSymbol) ENSMUST00000082647.1 ENSMUST00000082647.2 uc288wcg.1 uc288wcg.2 uc288wcg.1 uc288wcg.2 
ENSMUST00000082648.3 Gm25135 ENSMUST00000082648.3 Gm25135 (from geneSymbol) DQ542907 ENSMUST00000082648.1 ENSMUST00000082648.2 uc289lfw.1 uc289lfw.2 uc289lfw.1 uc289lfw.2 
ENSMUST00000082650.3 Gm25130 ENSMUST00000082650.3 Gm25130 (from geneSymbol) ENSMUST00000082650.1 ENSMUST00000082650.2 uc288wdw.1 uc288wdw.2 uc288wdw.1 uc288wdw.2 
ENSMUST00000082651.3 Gm25129 ENSMUST00000082651.3 Gm25129 (from geneSymbol) ENSMUST00000082651.1 ENSMUST00000082651.2 uc290cdj.1 uc290cdj.2 uc290cdj.1 uc290cdj.2 
ENSMUST00000082652.3 Gm25132 ENSMUST00000082652.3 Gm25132 (from geneSymbol) ENSMUST00000082652.1 ENSMUST00000082652.2 uc290fio.1 uc290fio.2 uc290fio.1 uc290fio.2 
ENSMUST00000082653.3 Gm25131 ENSMUST00000082653.3 Gm25131 (from geneSymbol) DQ542907 ENSMUST00000082653.1 ENSMUST00000082653.2 uc288zwl.1 uc288zwl.2 uc288zwl.1 uc288zwl.2 
ENSMUST00000082656.3 Gm22301 ENSMUST00000082656.3 Gm22301 (from geneSymbol) ENSMUST00000082656.1 ENSMUST00000082656.2 uc290hmk.1 uc290hmk.2 uc290hmk.1 uc290hmk.2 
ENSMUST00000082657.3 Gm22302 ENSMUST00000082657.3 Gm22302 (from geneSymbol) ENSMUST00000082657.1 ENSMUST00000082657.2 uc291opx.1 uc291opx.2 uc291opx.1 uc291opx.2 
ENSMUST00000082661.2 Gm22300 ENSMUST00000082661.2 Gm22300 (from geneSymbol) ENSMUST00000082661.1 uc290mwl.1 uc290mwl.2 uc290mwl.1 uc290mwl.2 
ENSMUST00000082662.3 Gm22298 ENSMUST00000082662.3 Gm22298 (from geneSymbol) ENSMUST00000082662.1 ENSMUST00000082662.2 uc289wea.1 uc289wea.2 uc289wea.1 uc289wea.2 
ENSMUST00000082663.3 Gm22299 ENSMUST00000082663.3 Gm22299 (from geneSymbol) ENSMUST00000082663.1 ENSMUST00000082663.2 uc288ydm.1 uc288ydm.2 uc288ydm.1 uc288ydm.2 
ENSMUST00000082666.3 Gm25636 ENSMUST00000082666.3 Gm25636 (from geneSymbol) ENSMUST00000082666.1 ENSMUST00000082666.2 uc291ukl.1 uc291ukl.2 uc291ukl.1 uc291ukl.2 
ENSMUST00000082667.3 Gm25634 ENSMUST00000082667.3 Gm25634 (from geneSymbol) ENSMUST00000082667.1 ENSMUST00000082667.2 uc287hfr.1 uc287hfr.2 uc287hfr.1 uc287hfr.2 
ENSMUST00000082668.3 Snora41 ENSMUST00000082668.3 small nucleolar RNA, H/ACA box 41 (from RefSeq NR_028558.1) ENSMUST00000082668.1 ENSMUST00000082668.2 NR_028558 uc011wme.1 uc011wme.2 uc011wme.3 uc011wme.1 uc011wme.2 uc011wme.3 
ENSMUST00000082670.3 Snora44 ENSMUST00000082670.3 small nucleolar RNA, H/ACA box 44 (from RefSeq NR_034050.1) ENSMUST00000082670.1 ENSMUST00000082670.2 NR_034050 uc290qkl.1 uc290qkl.2 uc290qkl.1 uc290qkl.2 
ENSMUST00000082671.5 Gm22220 ENSMUST00000082671.5 Gm22220 (from geneSymbol) AB349399 ENSMUST00000082671.1 ENSMUST00000082671.2 ENSMUST00000082671.3 ENSMUST00000082671.4 uc288gih.1 uc288gih.2 uc288gih.1 uc288gih.2 
ENSMUST00000082672.3 Gm25899 ENSMUST00000082672.3 Gm25899 (from geneSymbol) ENSMUST00000082672.1 ENSMUST00000082672.2 uc290nni.1 uc290nni.2 uc290nni.1 uc290nni.2 
ENSMUST00000082675.3 Gm25635 ENSMUST00000082675.3 Gm25635 (from geneSymbol) ENSMUST00000082675.1 ENSMUST00000082675.2 uc287pma.1 uc287pma.2 uc287pma.1 uc287pma.2 
ENSMUST00000082678.4 Gm26457 ENSMUST00000082678.4 Gm26457 (from geneSymbol) ENSMUST00000082678.1 ENSMUST00000082678.2 ENSMUST00000082678.3 uc287isc.1 uc287isc.2 uc287isc.1 uc287isc.2 
ENSMUST00000082679.3 Gm24621 ENSMUST00000082679.3 Gm24621 (from geneSymbol) ENSMUST00000082679.1 ENSMUST00000082679.2 uc290qca.1 uc290qca.2 uc290qca.1 uc290qca.2 
ENSMUST00000082685.2 Gm23975 ENSMUST00000082685.2 Gm23975 (from geneSymbol) ENSMUST00000082685.1 uc290lil.1 uc290lil.2 uc290lil.1 uc290lil.2 
ENSMUST00000082686.3 Gm22303 ENSMUST00000082686.3 Gm22303 (from geneSymbol) ENSMUST00000082686.1 ENSMUST00000082686.2 uc288fcn.1 uc288fcn.2 uc288fcn.1 uc288fcn.2 
ENSMUST00000082687.3 Gm26922 ENSMUST00000082687.3 predicted gene, 26922 (from RefSeq NR_028433.2) ENSMUST00000082687.1 ENSMUST00000082687.2 NR_028433 uc011ysw.1 uc011ysw.2 uc011ysw.3 uc011ysw.4 uc011ysw.1 uc011ysw.2 uc011ysw.3 uc011ysw.4 
ENSMUST00000082688.3 Gm22304 ENSMUST00000082688.3 Gm22304 (from geneSymbol) ENSMUST00000082688.1 ENSMUST00000082688.2 uc292hhj.1 uc292hhj.2 uc292hhj.1 uc292hhj.2 
ENSMUST00000082690.3 Gm22305 ENSMUST00000082690.3 Gm22305 (from geneSymbol) ENSMUST00000082690.1 ENSMUST00000082690.2 uc292buo.1 uc292buo.2 uc292buo.1 uc292buo.2 
ENSMUST00000082696.4 Gm25143 ENSMUST00000082696.4 Gm25143 (from geneSymbol) ENSMUST00000082696.1 ENSMUST00000082696.2 ENSMUST00000082696.3 uc287uqc.1 uc287uqc.2 uc287uqc.1 uc287uqc.2 
ENSMUST00000082698.3 Gm25142 ENSMUST00000082698.3 Gm25142 (from geneSymbol) DQ558729 ENSMUST00000082698.1 ENSMUST00000082698.2 uc287wki.1 uc287wki.2 uc287wki.1 uc287wki.2 
ENSMUST00000082700.3 Gm22620 ENSMUST00000082700.3 Gm22620 (from geneSymbol) ENSMUST00000082700.1 ENSMUST00000082700.2 uc292epu.1 uc292epu.2 uc292epu.1 uc292epu.2 
ENSMUST00000082703.3 Snora20 ENSMUST00000082703.3 Snora20 (from geneSymbol) AF357405 ENSMUST00000082703.1 ENSMUST00000082703.2 uc012aki.1 uc012aki.2 uc012aki.3 uc012aki.1 uc012aki.2 uc012aki.3 
ENSMUST00000082710.3 Gm23302 ENSMUST00000082710.3 Gm23302 (from geneSymbol) ENSMUST00000082710.1 ENSMUST00000082710.2 uc288wmb.1 uc288wmb.2 uc288wmb.1 uc288wmb.2 
ENSMUST00000082712.3 Gm23300 ENSMUST00000082712.3 Gm23300 (from geneSymbol) ENSMUST00000082712.1 ENSMUST00000082712.2 uc289rvq.1 uc289rvq.2 uc289rvq.1 uc289rvq.2 
ENSMUST00000082713.3 Gm23301 ENSMUST00000082713.3 Gm23301 (from geneSymbol) ENSMUST00000082713.1 ENSMUST00000082713.2 uc289pqn.1 uc289pqn.2 uc289pqn.1 uc289pqn.2 
ENSMUST00000082714.5 Gm23303 ENSMUST00000082714.5 Gm23303 (from geneSymbol) AK034787 ENSMUST00000082714.1 ENSMUST00000082714.2 ENSMUST00000082714.3 ENSMUST00000082714.4 uc290ruw.1 uc290ruw.2 uc290ruw.1 uc290ruw.2 
ENSMUST00000082718.3 Gm24165 ENSMUST00000082718.3 Gm24165 (from geneSymbol) ENSMUST00000082718.1 ENSMUST00000082718.2 uc289vfs.1 uc289vfs.2 uc289vfs.1 uc289vfs.2 
ENSMUST00000082719.3 Gm26129 ENSMUST00000082719.3 Gm26129 (from geneSymbol) DQ558729 ENSMUST00000082719.1 ENSMUST00000082719.2 uc288kxh.1 uc288kxh.2 uc288kxh.1 uc288kxh.2 
ENSMUST00000082721.3 Gm25788 ENSMUST00000082721.3 Gm25788 (from geneSymbol) ENSMUST00000082721.1 ENSMUST00000082721.2 uc290pqd.1 uc290pqd.2 uc290pqd.1 uc290pqd.2 
ENSMUST00000082724.3 Gm24166 ENSMUST00000082724.3 Gm24166 (from geneSymbol) ENSMUST00000082724.1 ENSMUST00000082724.2 uc292grr.1 uc292grr.2 uc292grr.1 uc292grr.2 
ENSMUST00000082725.4 Gm26131 ENSMUST00000082725.4 Gm26131 (from geneSymbol) DQ558729 ENSMUST00000082725.1 ENSMUST00000082725.2 ENSMUST00000082725.3 uc292nmw.1 uc292nmw.2 uc292nmw.1 uc292nmw.2 
ENSMUST00000082730.4 Gm24459 ENSMUST00000082730.4 Gm24459 (from geneSymbol) ENSMUST00000082730.1 ENSMUST00000082730.2 ENSMUST00000082730.3 uc292eah.1 uc292eah.2 uc292eah.1 uc292eah.2 
ENSMUST00000082731.3 Gm24460 ENSMUST00000082731.3 Gm24460 (from geneSymbol) ENSMUST00000082731.1 ENSMUST00000082731.2 uc292reo.1 uc292reo.2 uc292reo.1 uc292reo.2 
ENSMUST00000082732.3 Snora52 ENSMUST00000082732.3 small nucleolar RNA, H/ACA box 52 (from RefSeq NR_034049.2) ENSMUST00000082732.1 ENSMUST00000082732.2 NR_034049 uc291xee.1 uc291xee.2 uc291xee.1 uc291xee.2 
ENSMUST00000082733.3 Gm25453 ENSMUST00000082733.3 Gm25453 (from geneSymbol) ENSMUST00000082733.1 ENSMUST00000082733.2 uc289pwe.1 uc289pwe.2 uc289pwe.1 uc289pwe.2 
ENSMUST00000082735.3 Gm24461 ENSMUST00000082735.3 Gm24461 (from geneSymbol) ENSMUST00000082735.1 ENSMUST00000082735.2 uc289xhw.1 uc289xhw.2 uc289xhw.1 uc289xhw.2 
ENSMUST00000082736.3 Gm22808 ENSMUST00000082736.3 Gm22808 (from geneSymbol) DQ558729 ENSMUST00000082736.1 ENSMUST00000082736.2 uc289fuv.1 uc289fuv.2 uc289fuv.1 uc289fuv.2 
ENSMUST00000082737.3 Gm22807 ENSMUST00000082737.3 Gm22807 (from geneSymbol) ENSMUST00000082737.1 ENSMUST00000082737.2 uc287wvy.1 uc287wvy.2 uc287wvy.1 uc287wvy.2 
ENSMUST00000082738.3 Gm22806 ENSMUST00000082738.3 Gm22806 (from geneSymbol) ENSMUST00000082738.1 ENSMUST00000082738.2 uc288muq.1 uc288muq.2 uc288muq.1 uc288muq.2 
ENSMUST00000082739.3 Gm22805 ENSMUST00000082739.3 Gm22805 (from geneSymbol) DQ558729 ENSMUST00000082739.1 ENSMUST00000082739.2 uc292gzk.1 uc292gzk.2 uc292gzk.1 uc292gzk.2 
ENSMUST00000082741.4 Gm22810 ENSMUST00000082741.4 Gm22810 (from geneSymbol) ENSMUST00000082741.1 ENSMUST00000082741.2 ENSMUST00000082741.3 uc288xfk.1 uc288xfk.2 uc288xfk.1 uc288xfk.2 
ENSMUST00000082743.3 Gm22809 ENSMUST00000082743.3 Gm22809 (from geneSymbol) ENSMUST00000082743.1 ENSMUST00000082743.2 uc291wai.1 uc291wai.2 uc291wai.1 uc291wai.2 
ENSMUST00000082745.3 Gm25357 ENSMUST00000082745.3 Gm25357 (from geneSymbol) ENSMUST00000082745.1 ENSMUST00000082745.2 LF199329 uc288jeo.1 uc288jeo.2 uc288jeo.1 uc288jeo.2 
ENSMUST00000082748.3 Gm25813 ENSMUST00000082748.3 Gm25813 (from geneSymbol) DQ562105 ENSMUST00000082748.1 ENSMUST00000082748.2 uc291zws.1 uc291zws.2 uc291zws.1 uc291zws.2 
ENSMUST00000082751.3 Gm25812 ENSMUST00000082751.3 Gm25812 (from geneSymbol) DQ558729 ENSMUST00000082751.1 ENSMUST00000082751.2 uc292nmr.1 uc292nmr.2 uc292nmr.1 uc292nmr.2 
ENSMUST00000082752.3 Gm25810 ENSMUST00000082752.3 Gm25810 (from geneSymbol) DQ558729 ENSMUST00000082752.1 ENSMUST00000082752.2 uc289dqo.1 uc289dqo.2 uc289dqo.1 uc289dqo.2 
ENSMUST00000082753.3 Gm25811 ENSMUST00000082753.3 Gm25811 (from geneSymbol) ENSMUST00000082753.1 ENSMUST00000082753.2 uc290npa.1 uc290npa.2 uc290npa.1 uc290npa.2 
ENSMUST00000082754.3 Gm25814 ENSMUST00000082754.3 Gm25814 (from geneSymbol) ENSMUST00000082754.1 ENSMUST00000082754.2 uc287hay.1 uc287hay.2 uc287hay.1 uc287hay.2 
ENSMUST00000082755.3 Gm25815 ENSMUST00000082755.3 Gm25815 (from geneSymbol) ENSMUST00000082755.1 ENSMUST00000082755.2 uc291mdg.1 uc291mdg.2 uc291mdg.1 uc291mdg.2 
ENSMUST00000082758.3 Gm24151 ENSMUST00000082758.3 Gm24151 (from geneSymbol) ENSMUST00000082758.1 ENSMUST00000082758.2 uc287yxw.1 uc287yxw.2 uc287yxw.1 uc287yxw.2 
ENSMUST00000082759.3 Gm24150 ENSMUST00000082759.3 Gm24150 (from geneSymbol) ENSMUST00000082759.1 ENSMUST00000082759.2 uc290gaw.1 uc290gaw.2 uc290gaw.1 uc290gaw.2 
ENSMUST00000082763.3 Gm24147 ENSMUST00000082763.3 Gm24147 (from geneSymbol) ENSMUST00000082763.1 ENSMUST00000082763.2 uc292nuo.1 uc292nuo.2 uc292nuo.1 uc292nuo.2 
ENSMUST00000082764.2 Gm24152 ENSMUST00000082764.2 Gm24152 (from geneSymbol) ENSMUST00000082764.1 uc290lcx.1 uc290lcx.2 uc290lcx.1 uc290lcx.2 
ENSMUST00000082772.3 Gm54851 ENSMUST00000082772.3 Gm54851 (from geneSymbol) ENSMUST00000082772.1 ENSMUST00000082772.2 uc289poj.1 uc289poj.2 uc289poj.1 uc289poj.2 
ENSMUST00000082773.4 Gm22507 ENSMUST00000082773.4 Gm22507 (from geneSymbol) ENSMUST00000082773.1 ENSMUST00000082773.2 ENSMUST00000082773.3 uc287uwt.1 uc287uwt.2 uc287uwt.1 uc287uwt.2 
ENSMUST00000082781.3 Gm24207 ENSMUST00000082781.3 Gm24207 (from geneSymbol) ENSMUST00000082781.1 ENSMUST00000082781.2 uc288wid.1 uc288wid.2 uc288wid.1 uc288wid.2 
ENSMUST00000082782.2 Gm23423 ENSMUST00000082782.2 Gm23423 (from geneSymbol) ENSMUST00000082782.1 uc290lcd.1 uc290lcd.2 uc290lcd.1 uc290lcd.2 
ENSMUST00000082783.3 Gm24208 ENSMUST00000082783.3 Gm24208 (from geneSymbol) ENSMUST00000082783.1 ENSMUST00000082783.2 uc288eyy.1 uc288eyy.2 uc288eyy.1 uc288eyy.2 
ENSMUST00000082785.3 Gm25930 ENSMUST00000082785.3 Gm25930 (from geneSymbol) ENSMUST00000082785.1 ENSMUST00000082785.2 LF198488 uc287ybw.1 uc287ybw.2 uc287ybw.1 uc287ybw.2 
ENSMUST00000082786.3 Gm25856 ENSMUST00000082786.3 Gm25856 (from geneSymbol) ENSMUST00000082786.1 ENSMUST00000082786.2 uc288jew.1 uc288jew.2 uc288jew.1 uc288jew.2 
ENSMUST00000082787.6 Gm25855 ENSMUST00000082787.6 Gm25855 (from geneSymbol) DQ708131 ENSMUST00000082787.1 ENSMUST00000082787.2 ENSMUST00000082787.3 ENSMUST00000082787.4 ENSMUST00000082787.5 uc289qrm.1 uc289qrm.2 uc289qrm.1 uc289qrm.2 
ENSMUST00000082788.3 Gm25857 ENSMUST00000082788.3 Gm25857 (from geneSymbol) ENSMUST00000082788.1 ENSMUST00000082788.2 uc289zpo.1 uc289zpo.2 uc289zpo.1 uc289zpo.2 
ENSMUST00000082790.3 Gm25852 ENSMUST00000082790.3 Gm25852 (from geneSymbol) ENSMUST00000082790.1 ENSMUST00000082790.2 uc291hiy.1 uc291hiy.2 uc291hiy.1 uc291hiy.2 
ENSMUST00000082791.3 Snord96a ENSMUST00000082791.3 small nucleolar RNA, C/D box 96A (from RefSeq NR_028563.1) ENSMUST00000082791.1 ENSMUST00000082791.2 NR_028563 uc287xra.1 uc287xra.2 uc287xra.1 uc287xra.2 
ENSMUST00000082792.3 Gm25854 ENSMUST00000082792.3 Gm25854 (from geneSymbol) ENSMUST00000082792.1 ENSMUST00000082792.2 uc288jey.1 uc288jey.2 uc288jey.1 uc288jey.2 
ENSMUST00000082793.3 Gm25853 ENSMUST00000082793.3 Gm25853 (from geneSymbol) ENSMUST00000082793.1 ENSMUST00000082793.2 uc289fap.1 uc289fap.2 uc289fap.1 uc289fap.2 
ENSMUST00000082795.3 Gm22005 ENSMUST00000082795.3 Gm22005 (from geneSymbol) ENSMUST00000082795.1 ENSMUST00000082795.2 uc289sps.1 uc289sps.2 uc289sps.1 uc289sps.2 
ENSMUST00000082797.3 Snord45b ENSMUST00000082797.3 small nucleolar RNA, C/D box 45B (from RefSeq NR_028561.1) ENSMUST00000082797.1 ENSMUST00000082797.2 NR_028561 uc012czu.1 uc012czu.2 uc012czu.3 uc012czu.1 uc012czu.2 uc012czu.3 
ENSMUST00000082798.3 Gm23447 ENSMUST00000082798.3 Gm23447 (from geneSymbol) ENSMUST00000082798.1 ENSMUST00000082798.2 uc289mha.1 uc289mha.2 uc289mha.1 uc289mha.2 
ENSMUST00000082800.3 Gm23445 ENSMUST00000082800.3 Gm23445 (from geneSymbol) DQ558729 ENSMUST00000082800.1 ENSMUST00000082800.2 uc291vqk.1 uc291vqk.2 uc291vqk.1 uc291vqk.2 
ENSMUST00000082801.3 Gm23057 ENSMUST00000082801.3 Gm23057 (from geneSymbol) DQ558729 ENSMUST00000082801.1 ENSMUST00000082801.2 uc292iri.1 uc292iri.2 uc292iri.1 uc292iri.2 
ENSMUST00000082803.3 Gm23056 ENSMUST00000082803.3 Gm23056 (from geneSymbol) ENSMUST00000082803.1 ENSMUST00000082803.2 uc287llv.1 uc287llv.2 uc287llv.1 uc287llv.2 
ENSMUST00000082804.3 Gm23054 ENSMUST00000082804.3 Gm23054 (from geneSymbol) ENSMUST00000082804.1 ENSMUST00000082804.2 uc290grl.1 uc290grl.2 uc290grl.1 uc290grl.2 
ENSMUST00000082805.3 Gm23055 ENSMUST00000082805.3 Gm23055 (from geneSymbol) ENSMUST00000082805.1 ENSMUST00000082805.2 uc290qlq.1 uc290qlq.2 uc290qlq.1 uc290qlq.2 
ENSMUST00000082806.3 Snora70 ENSMUST00000082806.3 small nucleolar RNA, H/ACA box 70 (from RefSeq NR_002899.1) ENSMUST00000082806.1 ENSMUST00000082806.2 NR_002899 uc292pgh.1 uc292pgh.2 uc292pgh.1 uc292pgh.2 
ENSMUST00000082807.3 Snord14a ENSMUST00000082807.3 small nucleolar RNA, C/D box 14A (from RefSeq NR_028273.1) ENSMUST00000082807.1 ENSMUST00000082807.2 NR_028273 uc057lva.1 uc057lva.2 uc057lva.1 uc057lva.2 
ENSMUST00000082808.3 Rnu6-ps1 ENSMUST00000082808.3 Rnu6-ps1 (from geneSymbol) ENSMUST00000082808.1 ENSMUST00000082808.2 uc288ugs.1 uc288ugs.2 uc288ugs.1 uc288ugs.2 
ENSMUST00000082810.4 n-R5s86 ENSMUST00000082810.4 n-R5s86 (from geneSymbol) ENSMUST00000082810.1 ENSMUST00000082810.2 ENSMUST00000082810.3 uc292lzb.1 uc292lzb.2 uc292lzb.1 uc292lzb.2 
ENSMUST00000082811.3 Gm24708 ENSMUST00000082811.3 Gm24708 (from geneSymbol) ENSMUST00000082811.1 ENSMUST00000082811.2 uc291mbl.1 uc291mbl.2 uc291mbl.1 uc291mbl.2 
ENSMUST00000082814.3 n-R5s28 ENSMUST00000082814.3 n-R5s28 (from geneSymbol) AB352120 ENSMUST00000082814.1 ENSMUST00000082814.2 uc289lrz.1 uc289lrz.2 uc289lrz.1 uc289lrz.2 
ENSMUST00000082817.3 Gm26330 ENSMUST00000082817.3 Gm26330 (from geneSymbol) ENSMUST00000082817.1 ENSMUST00000082817.2 uc290pcs.1 uc290pcs.2 uc290pcs.1 uc290pcs.2 
ENSMUST00000082821.3 Gm26328 ENSMUST00000082821.3 Gm26328 (from geneSymbol) DQ558729 ENSMUST00000082821.1 ENSMUST00000082821.2 uc288tvg.1 uc288tvg.2 uc288tvg.1 uc288tvg.2 
ENSMUST00000082825.4 Gm25475 ENSMUST00000082825.4 Gm25475 (from geneSymbol) ENSMUST00000082825.1 ENSMUST00000082825.2 ENSMUST00000082825.3 uc288cjd.1 uc288cjd.2 uc288cjd.1 uc288cjd.2 
ENSMUST00000082827.3 Gm23514 ENSMUST00000082827.3 Gm23514 (from geneSymbol) ENSMUST00000082827.1 ENSMUST00000082827.2 uc287xbl.1 uc287xbl.2 uc287xbl.1 uc287xbl.2 
ENSMUST00000082828.3 Gm23738 ENSMUST00000082828.3 Gm23738 (from geneSymbol) ENSMUST00000082828.1 ENSMUST00000082828.2 uc290nfu.1 uc290nfu.2 uc290nfu.1 uc290nfu.2 
ENSMUST00000082829.3 Gm23515 ENSMUST00000082829.3 Gm23515 (from geneSymbol) DQ558729 ENSMUST00000082829.1 ENSMUST00000082829.2 uc292agy.1 uc292agy.2 uc292agy.1 uc292agy.2 
ENSMUST00000082830.3 Gm23517 ENSMUST00000082830.3 Gm23517 (from geneSymbol) ENSMUST00000082830.1 ENSMUST00000082830.2 uc289akm.1 uc289akm.2 uc289akm.1 uc289akm.2 
ENSMUST00000082831.4 Gm26456 ENSMUST00000082831.4 Gm26456 (from geneSymbol) ENSMUST00000082831.1 ENSMUST00000082831.2 ENSMUST00000082831.3 uc290kuc.1 uc290kuc.2 uc290kuc.1 uc290kuc.2 
ENSMUST00000082832.3 Gm26458 ENSMUST00000082832.3 Gm26458 (from geneSymbol) ENSMUST00000082832.1 ENSMUST00000082832.2 uc287wqi.1 uc287wqi.2 uc287wqi.1 uc287wqi.2 
ENSMUST00000082833.3 Snord35b ENSMUST00000082833.3 small nucleolar RNA, C/D box 35B (from RefSeq NR_000004.8) ENSMUST00000082833.1 ENSMUST00000082833.2 NR_000004 uc009gti.1 uc009gti.2 uc009gti.3 uc009gti.1 uc009gti.2 uc009gti.3 
ENSMUST00000082834.3 Snord60 ENSMUST00000082834.3 Snord60 (from geneSymbol) ENSMUST00000082834.1 ENSMUST00000082834.2 LF200935 uc289ibb.1 uc289ibb.2 uc289ibb.1 uc289ibb.2 
ENSMUST00000082835.3 Gm23518 ENSMUST00000082835.3 Gm23518 (from geneSymbol) AB353021 ENSMUST00000082835.1 ENSMUST00000082835.2 uc289eix.1 uc289eix.2 uc289eix.1 uc289eix.2 
ENSMUST00000082838.3 Gm25202 ENSMUST00000082838.3 Gm25202 (from geneSymbol) DQ562105 ENSMUST00000082838.1 ENSMUST00000082838.2 uc292nhy.1 uc292nhy.2 uc292nhy.1 uc292nhy.2 
ENSMUST00000082841.3 Gm25205 ENSMUST00000082841.3 Gm25205 (from geneSymbol) ENSMUST00000082841.1 ENSMUST00000082841.2 uc291fai.1 uc291fai.2 uc291fai.1 uc291fai.2 
ENSMUST00000082842.4 Gm25203 ENSMUST00000082842.4 Gm25203 (from geneSymbol) ENSMUST00000082842.1 ENSMUST00000082842.2 ENSMUST00000082842.3 uc288itm.1 uc288itm.2 uc288itm.1 uc288itm.2 
ENSMUST00000082843.3 Gm25204 ENSMUST00000082843.3 Gm25204 (from geneSymbol) ENSMUST00000082843.1 ENSMUST00000082843.2 uc288sky.1 uc288sky.2 uc288sky.1 uc288sky.2 
ENSMUST00000082844.4 Snord59a ENSMUST00000082844.4 Snord59a (from geneSymbol) ENSMUST00000082844.1 ENSMUST00000082844.2 ENSMUST00000082844.3 uc287vqg.1 uc287vqg.2 uc287vqg.1 uc287vqg.2 
ENSMUST00000082846.3 Snord95 ENSMUST00000082846.3 small nucleolar RNA, C/D box 95 (from RefSeq NR_028564.1) ENSMUST00000082846.1 ENSMUST00000082846.2 NR_028564 uc287xrb.1 uc287xrb.2 uc287xrb.1 uc287xrb.2 
ENSMUST00000082847.4 Gm22686 ENSMUST00000082847.4 Gm22686 (from geneSymbol) ENSMUST00000082847.1 ENSMUST00000082847.2 ENSMUST00000082847.3 uc292pgf.1 uc292pgf.2 uc292pgf.1 uc292pgf.2 
ENSMUST00000082848.2 Gm22685 ENSMUST00000082848.2 Gm22685 (from geneSymbol) DQ558729 ENSMUST00000082848.1 uc290mqr.1 uc290mqr.2 uc290mqr.1 uc290mqr.2 
ENSMUST00000082849.3 Gm22684 ENSMUST00000082849.3 Gm22684 (from geneSymbol) ENSMUST00000082849.1 ENSMUST00000082849.2 uc289rjm.1 uc289rjm.2 uc289rjm.1 uc289rjm.2 
ENSMUST00000082854.3 Gm22683 ENSMUST00000082854.3 Gm22683 (from geneSymbol) ENSMUST00000082854.1 ENSMUST00000082854.2 uc288crq.1 uc288crq.2 uc288crq.1 uc288crq.2 
ENSMUST00000082858.3 Gm24355 ENSMUST00000082858.3 Gm24355 (from geneSymbol) ENSMUST00000082858.1 ENSMUST00000082858.2 LF195500 uc291enx.1 uc291enx.2 uc291enx.1 uc291enx.2 
ENSMUST00000082859.3 Gm24356 ENSMUST00000082859.3 Gm24356 (from geneSymbol) ENSMUST00000082859.1 ENSMUST00000082859.2 uc291nin.1 uc291nin.2 uc291nin.1 uc291nin.2 
ENSMUST00000082861.3 Gm22423 ENSMUST00000082861.3 Gm22423 (from geneSymbol) ENSMUST00000082861.1 ENSMUST00000082861.2 uc288bqm.1 uc288bqm.2 uc288bqm.1 uc288bqm.2 
ENSMUST00000082863.3 Gm24357 ENSMUST00000082863.3 Gm24357 (from geneSymbol) ENSMUST00000082863.1 ENSMUST00000082863.2 uc292epv.1 uc292epv.2 uc292epv.1 uc292epv.2 
ENSMUST00000082866.3 Gm24948 ENSMUST00000082866.3 Gm24948 (from geneSymbol) ENSMUST00000082866.1 ENSMUST00000082866.2 uc288gey.1 uc288gey.2 uc288gey.1 uc288gey.2 
ENSMUST00000082867.3 Gm24035 ENSMUST00000082867.3 Gm24035 (from geneSymbol) ENSMUST00000082867.1 ENSMUST00000082867.2 uc292dkm.1 uc292dkm.2 uc292dkm.1 uc292dkm.2 
ENSMUST00000082868.3 Gm24036 ENSMUST00000082868.3 Gm24036 (from geneSymbol) ENSMUST00000082868.1 ENSMUST00000082868.2 uc287wrj.1 uc287wrj.2 uc287wrj.1 uc287wrj.2 
ENSMUST00000082870.4 Gm22622 ENSMUST00000082870.4 Gm22622 (from geneSymbol) ENSMUST00000082870.1 ENSMUST00000082870.2 ENSMUST00000082870.3 uc291eyh.1 uc291eyh.2 uc291eyh.1 uc291eyh.2 
ENSMUST00000082871.3 Gm24037 ENSMUST00000082871.3 Gm24037 (from geneSymbol) ENSMUST00000082871.1 ENSMUST00000082871.2 uc289xpv.1 uc289xpv.2 uc289xpv.1 uc289xpv.2 
ENSMUST00000082872.4 Gm24038 ENSMUST00000082872.4 Gm24038 (from geneSymbol) ENSMUST00000082872.1 ENSMUST00000082872.2 ENSMUST00000082872.3 uc292oad.1 uc292oad.2 uc292oad.1 uc292oad.2 
ENSMUST00000082877.3 Gm22358 ENSMUST00000082877.3 Gm22358 (from geneSymbol) ENSMUST00000082877.1 ENSMUST00000082877.2 uc288los.1 uc288los.2 uc288los.1 uc288los.2 
ENSMUST00000082880.3 Gm23939 ENSMUST00000082880.3 Gm23939 (from geneSymbol) ENSMUST00000082880.1 ENSMUST00000082880.2 uc287luh.1 uc287luh.2 uc287luh.1 uc287luh.2 
ENSMUST00000082882.3 Gm22357 ENSMUST00000082882.3 Gm22357 (from geneSymbol) ENSMUST00000082882.1 ENSMUST00000082882.2 uc287ncb.1 uc287ncb.2 uc287ncb.1 uc287ncb.2 
ENSMUST00000082884.3 Gm22359 ENSMUST00000082884.3 Gm22359 (from geneSymbol) ENSMUST00000082884.1 ENSMUST00000082884.2 uc292riv.1 uc292riv.2 uc292riv.1 uc292riv.2 
ENSMUST00000082888.2 Gm24292 ENSMUST00000082888.2 Gm24292 (from geneSymbol) DQ558729 ENSMUST00000082888.1 uc289nut.1 uc289nut.2 uc289nut.1 uc289nut.2 
ENSMUST00000082889.3 Snord82 ENSMUST00000082889.3 small nucleolar RNA, C/D box 82 (from RefSeq NR_002851.1) ENSMUST00000082889.1 ENSMUST00000082889.2 NR_002851 uc007bvm.1 uc007bvm.2 uc007bvm.3 uc007bvm.1 uc007bvm.2 uc007bvm.3 
ENSMUST00000082890.3 Gm22443 ENSMUST00000082890.3 Gm22443 (from geneSymbol) ENSMUST00000082890.1 ENSMUST00000082890.2 uc289req.1 uc289req.2 uc289req.1 uc289req.2 
ENSMUST00000082895.5 Gm22879 ENSMUST00000082895.5 Gm22879 (from geneSymbol) ENSMUST00000082895.1 ENSMUST00000082895.2 ENSMUST00000082895.3 ENSMUST00000082895.4 uc289ugp.1 uc289ugp.2 uc289ugp.1 uc289ugp.2 
ENSMUST00000082896.3 Gm25699 ENSMUST00000082896.3 Gm25699 (from geneSymbol) ENSMUST00000082896.1 ENSMUST00000082896.2 uc289flx.1 uc289flx.2 uc289flx.1 uc289flx.2 
ENSMUST00000082899.3 Gm25926 ENSMUST00000082899.3 Gm25926 (from geneSymbol) AK140755 ENSMUST00000082899.1 ENSMUST00000082899.2 uc288hja.1 uc288hja.2 uc288hja.1 uc288hja.2 
ENSMUST00000082900.3 Gm25696 ENSMUST00000082900.3 Gm25696 (from geneSymbol) ENSMUST00000082900.1 ENSMUST00000082900.2 uc290enz.1 uc290enz.2 uc290enz.1 uc290enz.2 
ENSMUST00000082902.3 Gm25697 ENSMUST00000082902.3 Gm25697 (from geneSymbol) ENSMUST00000082902.1 ENSMUST00000082902.2 uc288rtf.1 uc288rtf.2 uc288rtf.1 uc288rtf.2 
ENSMUST00000082903.3 Snora75 ENSMUST00000082903.3 small nucleolar RNA, H/ACA box 75 (from RefSeq NR_028478.2) ENSMUST00000082903.1 ENSMUST00000082903.2 NR_028478 uc287kab.1 uc287kab.2 uc287kab.1 uc287kab.2 
ENSMUST00000082907.3 Gm26205 ENSMUST00000082907.3 Gm26205 (from geneSymbol) AK141707 ENSMUST00000082907.1 ENSMUST00000082907.2 uc290zec.1 uc290zec.2 uc290zec.1 uc290zec.2 
ENSMUST00000082908.3 Gm26206 ENSMUST00000082908.3 Gm26206 (from geneSymbol) ENSMUST00000082908.1 ENSMUST00000082908.2 uc287gdc.1 uc287gdc.2 uc287gdc.1 uc287gdc.2 
ENSMUST00000082909.3 Gm26207 ENSMUST00000082909.3 Gm26207 (from geneSymbol) ENSMUST00000082909.1 ENSMUST00000082909.2 uc289rlt.1 uc289rlt.2 uc289rlt.1 uc289rlt.2 
ENSMUST00000082910.3 Gm26202 ENSMUST00000082910.3 Gm26202 (from geneSymbol) ENSMUST00000082910.1 ENSMUST00000082910.2 uc289pqo.1 uc289pqo.2 uc289pqo.1 uc289pqo.2 
ENSMUST00000082911.4 Gm26203 ENSMUST00000082911.4 Gm26203 (from geneSymbol) DQ558729 ENSMUST00000082911.1 ENSMUST00000082911.2 ENSMUST00000082911.3 uc287ozy.1 uc287ozy.2 uc287ozy.1 uc287ozy.2 
ENSMUST00000082916.3 Gm23443 ENSMUST00000082916.3 Gm23443 (from geneSymbol) ENSMUST00000082916.1 ENSMUST00000082916.2 uc290nty.1 uc290nty.2 uc290nty.1 uc290nty.2 
ENSMUST00000082917.3 Gm24525 ENSMUST00000082917.3 Gm24525 (from geneSymbol) ENSMUST00000082917.1 ENSMUST00000082917.2 uc290sxv.1 uc290sxv.2 uc290sxv.1 uc290sxv.2 
ENSMUST00000082919.3 Gm23442 ENSMUST00000082919.3 Gm23442 (from geneSymbol) ENSMUST00000082919.1 ENSMUST00000082919.2 uc289kma.1 uc289kma.2 uc289kma.1 uc289kma.2 
ENSMUST00000082920.3 Gm24527 ENSMUST00000082920.3 Gm24527 (from geneSymbol) ENSMUST00000082920.1 ENSMUST00000082920.2 uc288ptm.1 uc288ptm.2 uc288ptm.1 uc288ptm.2 
ENSMUST00000082921.3 Gm24526 ENSMUST00000082921.3 Gm24526 (from geneSymbol) ENSMUST00000082921.1 ENSMUST00000082921.2 uc292iaj.1 uc292iaj.2 uc292iaj.1 uc292iaj.2 
ENSMUST00000082923.3 n-R5s25 ENSMUST00000082923.3 n-R5s25 (from geneSymbol) ENSMUST00000082923.1 ENSMUST00000082923.2 uc289oqk.1 uc289oqk.2 uc289oqk.1 uc289oqk.2 
ENSMUST00000082924.4 Snora43 ENSMUST00000082924.4 Snora43 (from geneSymbol) ENSMUST00000082924.1 ENSMUST00000082924.2 ENSMUST00000082924.3 uc289ufy.1 uc289ufy.2 uc289ufy.1 uc289ufy.2 
ENSMUST00000082925.3 Gm24524 ENSMUST00000082925.3 Gm24524 (from geneSymbol) ENSMUST00000082925.1 ENSMUST00000082925.2 uc290wta.1 uc290wta.2 uc290wta.1 uc290wta.2 
ENSMUST00000082928.3 Gm25038 ENSMUST00000082928.3 Gm25038 (from geneSymbol) ENSMUST00000082928.1 ENSMUST00000082928.2 uc289fqk.1 uc289fqk.2 uc289fqk.1 uc289fqk.2 
ENSMUST00000082931.4 Gm22113 ENSMUST00000082931.4 Gm22113 (from geneSymbol) ENSMUST00000082931.1 ENSMUST00000082931.2 ENSMUST00000082931.3 uc289sie.1 uc289sie.2 uc289sie.1 uc289sie.2 
ENSMUST00000082933.3 Gm25039 ENSMUST00000082933.3 Gm25039 (from geneSymbol) DQ558729 ENSMUST00000082933.1 ENSMUST00000082933.2 uc290ghv.1 uc290ghv.2 uc290ghv.1 uc290ghv.2 
ENSMUST00000082937.3 Snord58b ENSMUST00000082937.3 small nucleolar RNA, C/D box 58B (from RefSeq NR_028552.1) ENSMUST00000082937.1 ENSMUST00000082937.2 NR_028552 uc012bez.1 uc012bez.2 uc012bez.3 uc012bez.1 uc012bez.2 uc012bez.3 
ENSMUST00000082938.3 Gm23376 ENSMUST00000082938.3 Gm23376 (from geneSymbol) ENSMUST00000082938.1 ENSMUST00000082938.2 uc290gih.1 uc290gih.2 uc290gih.1 uc290gih.2 
ENSMUST00000082942.3 Gm23378 ENSMUST00000082942.3 Gm23378 (from geneSymbol) ENSMUST00000082942.1 ENSMUST00000082942.2 uc292pyb.1 uc292pyb.2 uc292pyb.1 uc292pyb.2 
ENSMUST00000082943.5 Gm23377 ENSMUST00000082943.5 Gm23377 (from geneSymbol) ENSMUST00000082943.1 ENSMUST00000082943.2 ENSMUST00000082943.3 ENSMUST00000082943.4 uc292lpr.1 uc292lpr.2 uc292lpr.1 uc292lpr.2 
ENSMUST00000082946.3 Gm24201 ENSMUST00000082946.3 Gm24201 (from geneSymbol) ENSMUST00000082946.1 ENSMUST00000082946.2 uc289dtj.1 uc289dtj.2 uc289dtj.1 uc289dtj.2 
ENSMUST00000082947.3 Gm22265 ENSMUST00000082947.3 Gm22265 (from geneSymbol) DQ561416 ENSMUST00000082947.1 ENSMUST00000082947.2 uc287pbl.1 uc287pbl.2 uc287pbl.1 uc287pbl.2 
ENSMUST00000082948.4 Gm24202 ENSMUST00000082948.4 Gm24202 (from geneSymbol) ENSMUST00000082948.1 ENSMUST00000082948.2 ENSMUST00000082948.3 uc291zcz.1 uc291zcz.2 uc291zcz.1 uc291zcz.2 
ENSMUST00000082949.3 Gm24203 ENSMUST00000082949.3 Gm24203 (from geneSymbol) ENSMUST00000082949.1 ENSMUST00000082949.2 uc290nxu.1 uc290nxu.2 uc290nxu.1 uc290nxu.2 
ENSMUST00000082950.3 Gm24204 ENSMUST00000082950.3 Gm24204 (from geneSymbol) ENSMUST00000082950.1 ENSMUST00000082950.2 uc288ztp.1 uc288ztp.2 uc288ztp.1 uc288ztp.2 
ENSMUST00000082955.3 Gm24200 ENSMUST00000082955.3 Gm24200 (from geneSymbol) AB353021 ENSMUST00000082955.1 ENSMUST00000082955.2 uc292jrj.1 uc292jrj.2 uc292jrj.1 uc292jrj.2 
ENSMUST00000082956.3 Gm22505 ENSMUST00000082956.3 Gm22505 (from geneSymbol) DQ558729 ENSMUST00000082956.1 ENSMUST00000082956.2 uc290iaa.1 uc290iaa.2 uc290iaa.1 uc290iaa.2 
ENSMUST00000082963.3 Gm22504 ENSMUST00000082963.3 Gm22504 (from geneSymbol) ENSMUST00000082963.1 ENSMUST00000082963.2 uc291uaf.1 uc291uaf.2 uc291uaf.1 uc291uaf.2 
ENSMUST00000082965.3 Snord118 ENSMUST00000082965.3 small nucleolar RNA, C/D box 118 (from RefSeq NR_028566.3) ENSMUST00000082965.1 ENSMUST00000082965.2 NR_028566 uc057klk.1 uc057klk.2 uc057klk.3 uc057klk.1 uc057klk.2 uc057klk.3 
ENSMUST00000082966.3 Gm25402 ENSMUST00000082966.3 Gm25402 (from geneSymbol) ENSMUST00000082966.1 ENSMUST00000082966.2 uc291drk.1 uc291drk.2 uc291drk.1 uc291drk.2 
ENSMUST00000082967.3 Snora21 ENSMUST00000082967.3 small nucleolar RNA, H/ACA box 21 (from RefSeq NR_028078.1) ENSMUST00000082967.1 ENSMUST00000082967.2 NR_028078 uc011ydw.1 uc011ydw.2 uc011ydw.3 uc011ydw.1 uc011ydw.2 uc011ydw.3 
ENSMUST00000082970.3 Gm25404 ENSMUST00000082970.3 Gm25404 (from geneSymbol) ENSMUST00000082970.1 ENSMUST00000082970.2 uc290fiz.1 uc290fiz.2 uc290fiz.1 uc290fiz.2 
ENSMUST00000082972.3 n-R5s204 ENSMUST00000082972.3 n-R5s204 (from geneSymbol) ENSMUST00000082972.1 ENSMUST00000082972.2 uc289zpf.1 uc289zpf.2 uc289zpf.1 uc289zpf.2 
ENSMUST00000082975.3 Gm25401 ENSMUST00000082975.3 Gm25401 (from geneSymbol) ENSMUST00000082975.1 ENSMUST00000082975.2 uc292gfz.1 uc292gfz.2 uc292gfz.1 uc292gfz.2 
ENSMUST00000082981.3 Gm22575 ENSMUST00000082981.3 Gm22575 (from geneSymbol) ENSMUST00000082981.1 ENSMUST00000082981.2 uc290jjz.1 uc290jjz.2 uc290jjz.1 uc290jjz.2 
ENSMUST00000082982.3 Gm22573 ENSMUST00000082982.3 Gm22573 (from geneSymbol) ENSMUST00000082982.1 ENSMUST00000082982.2 uc290smr.1 uc290smr.2 uc290smr.1 uc290smr.2 
ENSMUST00000082983.2 Snord138 ENSMUST00000082983.2 Snord138 (from geneSymbol) AJ240057 ENSMUST00000082983.1 uc288ozi.1 uc288ozi.2 uc288ozi.1 uc288ozi.2 
ENSMUST00000082984.5 Gm22571 ENSMUST00000082984.5 Gm22571 (from geneSymbol) ENSMUST00000082984.1 ENSMUST00000082984.2 ENSMUST00000082984.3 ENSMUST00000082984.4 uc292ice.1 uc292ice.2 uc292ice.1 uc292ice.2 
ENSMUST00000082985.3 Gm22572 ENSMUST00000082985.3 Gm22572 (from geneSymbol) ENSMUST00000082985.1 ENSMUST00000082985.2 uc289tuh.1 uc289tuh.2 uc289tuh.1 uc289tuh.2 
ENSMUST00000082987.3 Gm22229 ENSMUST00000082987.3 Gm22229 (from geneSymbol) ENSMUST00000082987.1 ENSMUST00000082987.2 uc292img.1 uc292img.2 uc292img.1 uc292img.2 
ENSMUST00000082989.2 Gm22042 ENSMUST00000082989.2 Gm22042 (from geneSymbol) AB349931 ENSMUST00000082989.1 uc290msb.1 uc290msb.2 uc290msb.1 uc290msb.2 
ENSMUST00000082990.4 Gm24268 ENSMUST00000082990.4 Gm24268 (from geneSymbol) ENSMUST00000082990.1 ENSMUST00000082990.2 ENSMUST00000082990.3 uc292rja.1 uc292rja.2 uc292rja.1 uc292rja.2 
ENSMUST00000082991.3 Snora62 ENSMUST00000082991.3 small nucleolar RNA, H/ACA box 62 (from RefSeq NR_002902.2) ENSMUST00000082991.1 ENSMUST00000082991.2 NR_002902 uc009scg.1 uc009scg.2 uc009scg.3 uc009scg.4 uc009scg.1 uc009scg.2 uc009scg.3 uc009scg.4 
ENSMUST00000082993.3 Gm22043 ENSMUST00000082993.3 Gm22043 (from geneSymbol) ENSMUST00000082993.1 ENSMUST00000082993.2 uc290ewr.1 uc290ewr.2 uc290ewr.1 uc290ewr.2 
ENSMUST00000082994.3 Gm22045 ENSMUST00000082994.3 Gm22045 (from geneSymbol) DQ558729 ENSMUST00000082994.1 ENSMUST00000082994.2 uc289awy.1 uc289awy.2 uc289awy.1 uc289awy.2 
ENSMUST00000082996.3 Gm23723 ENSMUST00000082996.3 Gm23723 (from geneSymbol) ENSMUST00000082996.1 ENSMUST00000082996.2 uc290hap.1 uc290hap.2 uc290hap.1 uc290hap.2 
ENSMUST00000083002.3 Gm23722 ENSMUST00000083002.3 Gm23722 (from geneSymbol) ENSMUST00000083002.1 ENSMUST00000083002.2 uc287hop.1 uc287hop.2 uc287hop.1 uc287hop.2 
ENSMUST00000083006.4 Gm23239 ENSMUST00000083006.4 Gm23239 (from geneSymbol) ENSMUST00000083006.1 ENSMUST00000083006.2 ENSMUST00000083006.3 uc291rnu.1 uc291rnu.2 uc291rnu.1 uc291rnu.2 
ENSMUST00000083007.3 Gm23238 ENSMUST00000083007.3 Gm23238 (from geneSymbol) AB351594 ENSMUST00000083007.1 ENSMUST00000083007.2 uc289rjh.1 uc289rjh.2 uc289rjh.1 uc289rjh.2 
ENSMUST00000083009.3 Gm23240 ENSMUST00000083009.3 Gm23240 (from geneSymbol) DQ548138 ENSMUST00000083009.1 ENSMUST00000083009.2 uc287hxk.1 uc287hxk.2 uc287hxk.1 uc287hxk.2 
ENSMUST00000083011.3 Rny3 ENSMUST00000083011.3 RNA, Y3 small cytoplasmic (associated with Ro protein) (from RefSeq NR_024202.2) ENSMUST00000083011.1 ENSMUST00000083011.2 NR_024202 uc057lpw.1 uc057lpw.2 uc057lpw.3 uc057lpw.1 uc057lpw.2 uc057lpw.3 
ENSMUST00000083014.4 Gm23241 ENSMUST00000083014.4 Gm23241 (from geneSymbol) DQ558729 ENSMUST00000083014.1 ENSMUST00000083014.2 ENSMUST00000083014.3 uc287vsc.1 uc287vsc.2 uc287vsc.1 uc287vsc.2 
ENSMUST00000083015.3 Snora61 ENSMUST00000083015.3 Snora61 (from geneSymbol) AF357401 ENSMUST00000083015.1 ENSMUST00000083015.2 uc290qkn.1 uc290qkn.2 uc290qkn.1 uc290qkn.2 
ENSMUST00000083018.3 Gm24920 ENSMUST00000083018.3 Gm24920 (from geneSymbol) ENSMUST00000083018.1 ENSMUST00000083018.2 uc290hmj.1 uc290hmj.2 uc290hmj.1 uc290hmj.2 
ENSMUST00000083020.3 Gm24919 ENSMUST00000083020.3 Gm24919 (from geneSymbol) ENSMUST00000083020.1 ENSMUST00000083020.2 uc287ohj.1 uc287ohj.2 uc287ohj.1 uc287ohj.2 
ENSMUST00000083022.2 Gm24918 ENSMUST00000083022.2 Gm24918 (from geneSymbol) ENSMUST00000083022.1 LF197409 uc292egm.1 uc292egm.2 uc292egm.1 uc292egm.2 
ENSMUST00000083024.4 Gm24921 ENSMUST00000083024.4 Gm24921 (from geneSymbol) ENSMUST00000083024.1 ENSMUST00000083024.2 ENSMUST00000083024.3 uc288grr.1 uc288grr.2 uc288grr.1 uc288grr.2 
ENSMUST00000083025.3 n-R5s41 ENSMUST00000083025.3 n-R5s41 (from geneSymbol) ENSMUST00000083025.1 ENSMUST00000083025.2 LF200400 uc289aco.1 uc289aco.2 uc289aco.1 uc289aco.2 
ENSMUST00000083027.3 Gm22704 ENSMUST00000083027.3 Gm22704 (from geneSymbol) ENSMUST00000083027.1 ENSMUST00000083027.2 uc290cuv.1 uc290cuv.2 uc290cuv.1 uc290cuv.2 
ENSMUST00000083029.4 Gm24311 ENSMUST00000083029.4 Gm24311 (from geneSymbol) ENSMUST00000083029.1 ENSMUST00000083029.2 ENSMUST00000083029.3 uc290tio.1 uc290tio.2 uc290tio.1 uc290tio.2 
ENSMUST00000083030.3 Gm25147 ENSMUST00000083030.3 Gm25147 (from geneSymbol) ENSMUST00000083030.1 ENSMUST00000083030.2 uc289til.1 uc289til.2 uc289til.1 uc289til.2 
ENSMUST00000083032.3 Snord15b ENSMUST00000083032.3 small nucleolar RNA, C/D box 15B (from RefSeq NR_002173.1) ENSMUST00000083032.1 ENSMUST00000083032.2 NR_002173 uc012fpv.1 uc012fpv.2 uc012fpv.1 uc012fpv.2 
ENSMUST00000083033.3 Gm24405 ENSMUST00000083033.3 Gm24405 (from geneSymbol) DQ548138 ENSMUST00000083033.1 ENSMUST00000083033.2 uc287ohm.1 uc287ohm.2 uc287ohm.1 uc287ohm.2 
ENSMUST00000083034.3 Snord47 ENSMUST00000083034.3 small nucleolar RNA, C/D box 47 (from RefSeq NR_028543.1) ENSMUST00000083034.1 ENSMUST00000083034.2 NR_028543 uc287ncm.1 uc287ncm.2 uc287ncm.1 uc287ncm.2 
ENSMUST00000083036.3 Gm23690 ENSMUST00000083036.3 Gm23690 (from geneSymbol) ENSMUST00000083036.1 ENSMUST00000083036.2 uc287onu.1 uc287onu.2 uc287onu.1 uc287onu.2 
ENSMUST00000083043.3 Gm26056 ENSMUST00000083043.3 Gm26056 (from geneSymbol) ENSMUST00000083043.1 ENSMUST00000083043.2 uc291lvq.1 uc291lvq.2 uc291lvq.1 uc291lvq.2 
ENSMUST00000083047.3 Gm24706 ENSMUST00000083047.3 Gm24706 (from geneSymbol) ENSMUST00000083047.1 ENSMUST00000083047.2 uc292owy.1 uc292owy.2 uc292owy.1 uc292owy.2 
ENSMUST00000083048.3 Gm25259 ENSMUST00000083048.3 Gm25259 (from geneSymbol) ENSMUST00000083048.1 ENSMUST00000083048.2 uc291nvr.1 uc291nvr.2 uc291nvr.1 uc291nvr.2 
ENSMUST00000083050.3 Snord73a ENSMUST00000083050.3 small nucleolar RNA, C/D box U73A (from RefSeq NR_004417.1) ENSMUST00000083050.1 ENSMUST00000083050.2 NR_004417 uc012crb.1 uc012crb.2 uc012crb.1 uc012crb.2 
ENSMUST00000083053.4 Gm25260 ENSMUST00000083053.4 Gm25260 (from geneSymbol) ENSMUST00000083053.1 ENSMUST00000083053.2 ENSMUST00000083053.3 uc291fel.1 uc291fel.2 uc291fel.1 uc291fel.2 
ENSMUST00000083060.3 Gm22422 ENSMUST00000083060.3 Gm22422 (from geneSymbol) ENSMUST00000083060.1 ENSMUST00000083060.2 uc289fbn.1 uc289fbn.2 uc289fbn.1 uc289fbn.2 
ENSMUST00000083061.3 Gm26003 ENSMUST00000083061.3 Gm26003 (from geneSymbol) ENSMUST00000083061.1 ENSMUST00000083061.2 uc290ccz.1 uc290ccz.2 uc290ccz.1 uc290ccz.2 
ENSMUST00000083063.4 Gm24539 ENSMUST00000083063.4 Gm24539 (from geneSymbol) ENSMUST00000083063.1 ENSMUST00000083063.2 ENSMUST00000083063.3 uc288nqc.1 uc288nqc.2 uc288nqc.1 uc288nqc.2 
ENSMUST00000083070.3 Gm26326 ENSMUST00000083070.3 Gm26326 (from geneSymbol) ENSMUST00000083070.1 ENSMUST00000083070.2 uc288gdb.1 uc288gdb.2 uc288gdb.1 uc288gdb.2 
ENSMUST00000083072.3 Gm26325 ENSMUST00000083072.3 Gm26325 (from geneSymbol) ENSMUST00000083072.1 ENSMUST00000083072.2 uc291lqi.1 uc291lqi.2 uc291lqi.1 uc291lqi.2 
ENSMUST00000083077.3 Gm24612 ENSMUST00000083077.3 Gm24612 (from geneSymbol) DQ558729 ENSMUST00000083077.1 ENSMUST00000083077.2 uc288ban.1 uc288ban.2 uc288ban.1 uc288ban.2 
ENSMUST00000083078.3 Gm23507 ENSMUST00000083078.3 Gm23507 (from geneSymbol) DQ558729 ENSMUST00000083078.1 ENSMUST00000083078.2 uc288bhn.1 uc288bhn.2 uc288bhn.1 uc288bhn.2 
ENSMUST00000083079.3 Gm23508 ENSMUST00000083079.3 Gm23508 (from geneSymbol) ENSMUST00000083079.1 ENSMUST00000083079.2 LF199329 uc288jen.1 uc288jen.2 uc288jen.1 uc288jen.2 
ENSMUST00000083080.3 Gm23509 ENSMUST00000083080.3 Gm23509 (from geneSymbol) ENSMUST00000083080.1 ENSMUST00000083080.2 uc288wbf.1 uc288wbf.2 uc288wbf.1 uc288wbf.2 
ENSMUST00000083082.3 Snora3 ENSMUST00000083082.3 small nucleolar RNA, H/ACA box 3 (from RefSeq NR_028079.1) ENSMUST00000083082.1 ENSMUST00000083082.2 NR_028079 uc291uiw.1 uc291uiw.2 uc291uiw.1 uc291uiw.2 
ENSMUST00000083084.3 Gm23330 ENSMUST00000083084.3 Gm23330 (from geneSymbol) DQ548138 ENSMUST00000083084.1 ENSMUST00000083084.2 uc290faj.1 uc290faj.2 uc290faj.1 uc290faj.2 
ENSMUST00000083088.3 AF357341 ENSMUST00000083088.3 AF357341 (from geneSymbol) ENSMUST00000083088.1 ENSMUST00000083088.2 uc288jeu.1 uc288jeu.2 uc288jeu.1 uc288jeu.2 
ENSMUST00000083093.3 Gm25201 ENSMUST00000083093.3 Gm25201 (from geneSymbol) ENSMUST00000083093.1 ENSMUST00000083093.2 uc289lry.1 uc289lry.2 uc289lry.1 uc289lry.2 
ENSMUST00000083094.3 Gm25200 ENSMUST00000083094.3 Gm25200 (from geneSymbol) ENSMUST00000083094.1 ENSMUST00000083094.2 uc292dkg.1 uc292dkg.2 uc292dkg.1 uc292dkg.2 
ENSMUST00000083095.3 Gm25199 ENSMUST00000083095.3 Gm25199 (from geneSymbol) ENSMUST00000083095.1 ENSMUST00000083095.2 uc290igc.1 uc290igc.2 uc290igc.1 uc290igc.2 
ENSMUST00000083097.3 Gm22364 ENSMUST00000083097.3 Gm22364 (from geneSymbol) ENSMUST00000083097.1 ENSMUST00000083097.2 uc292nrx.1 uc292nrx.2 uc292nrx.1 uc292nrx.2 
ENSMUST00000083099.3 Gm24871 ENSMUST00000083099.3 Gm24871 (from geneSymbol) AK047216 ENSMUST00000083099.1 ENSMUST00000083099.2 uc287nuy.1 uc287nuy.2 uc287nuy.1 uc287nuy.2 
ENSMUST00000083100.3 Gm22363 ENSMUST00000083100.3 Gm22363 (from geneSymbol) DQ558729 ENSMUST00000083100.1 ENSMUST00000083100.2 uc291dyw.1 uc291dyw.2 uc291dyw.1 uc291dyw.2 
ENSMUST00000083102.3 Gm22362 ENSMUST00000083102.3 Gm22362 (from geneSymbol) ENSMUST00000083102.1 ENSMUST00000083102.2 uc291jno.1 uc291jno.2 uc291jno.1 uc291jno.2 
ENSMUST00000083106.2 Gm24977 ENSMUST00000083106.2 Gm24977 (from geneSymbol) ENSMUST00000083106.1 uc290lmz.1 uc290lmz.2 uc290lmz.1 uc290lmz.2 
ENSMUST00000083107.3 Gm24044 ENSMUST00000083107.3 Gm24044 (from geneSymbol) ENSMUST00000083107.1 ENSMUST00000083107.2 uc292met.1 uc292met.2 uc292met.1 uc292met.2 
ENSMUST00000083108.3 Gm24043 ENSMUST00000083108.3 Gm24043 (from geneSymbol) ENSMUST00000083108.1 ENSMUST00000083108.2 uc288wcf.1 uc288wcf.2 uc288wcf.1 uc288wcf.2 
ENSMUST00000083111.3 Gm24046 ENSMUST00000083111.3 Gm24046 (from geneSymbol) ENSMUST00000083111.1 ENSMUST00000083111.2 uc290gys.1 uc290gys.2 uc290gys.1 uc290gys.2 
ENSMUST00000083112.3 Gm22192 ENSMUST00000083112.3 Gm22192 (from geneSymbol) ENSMUST00000083112.1 ENSMUST00000083112.2 LF193251 uc289uzw.1 uc289uzw.2 uc289uzw.1 uc289uzw.2 
ENSMUST00000083113.3 Gm24045 ENSMUST00000083113.3 Gm24045 (from geneSymbol) AK080459 ENSMUST00000083113.1 ENSMUST00000083113.2 uc290oui.1 uc290oui.2 uc290oui.1 uc290oui.2 
ENSMUST00000083114.4 Gm24042 ENSMUST00000083114.4 Gm24042 (from geneSymbol) ENSMUST00000083114.1 ENSMUST00000083114.2 ENSMUST00000083114.3 uc290lnb.1 uc290lnb.2 uc290lnb.1 uc290lnb.2 
ENSMUST00000083115.4 Gm24041 ENSMUST00000083115.4 Gm24041 (from geneSymbol) ENSMUST00000083115.1 ENSMUST00000083115.2 ENSMUST00000083115.3 LF200260 uc288yes.1 uc288yes.2 uc288yes.1 uc288yes.2 
ENSMUST00000083116.4 Gm25704 ENSMUST00000083116.4 Gm25704 (from geneSymbol) ENSMUST00000083116.1 ENSMUST00000083116.2 ENSMUST00000083116.3 uc290ato.1 uc290ato.2 uc290ato.1 uc290ato.2 
ENSMUST00000083119.2 Gm25705 ENSMUST00000083119.2 Gm25705 (from geneSymbol) ENSMUST00000083119.1 uc290lor.1 uc290lor.2 uc290lor.1 uc290lor.2 
ENSMUST00000083123.3 Gm25703 ENSMUST00000083123.3 Gm25703 (from geneSymbol) ENSMUST00000083123.1 ENSMUST00000083123.2 uc290aka.1 uc290aka.2 uc290aka.1 uc290aka.2 
ENSMUST00000083127.3 Gm22884 ENSMUST00000083127.3 predicted gene 12238 (from RefSeq NR_028480.1) ENSMUST00000083127.1 ENSMUST00000083127.2 NR_028480 uc287yhj.1 uc287yhj.2 uc287yhj.1 uc287yhj.2 
ENSMUST00000083138.3 Gm24533 ENSMUST00000083138.3 Gm24533 (from geneSymbol) ENSMUST00000083138.1 ENSMUST00000083138.2 uc291fwm.1 uc291fwm.2 uc291fwm.1 uc291fwm.2 
ENSMUST00000083140.3 Gm24535 ENSMUST00000083140.3 Gm24535 (from geneSymbol) DQ558729 ENSMUST00000083140.1 ENSMUST00000083140.2 uc292nmn.1 uc292nmn.2 uc292nmn.1 uc292nmn.2 
ENSMUST00000083144.3 Gm24536 ENSMUST00000083144.3 Gm24536 (from geneSymbol) ENSMUST00000083144.1 ENSMUST00000083144.2 uc291ddc.1 uc291ddc.2 uc291ddc.1 uc291ddc.2 
ENSMUST00000083145.3 Gm23464 ENSMUST00000083145.3 Gm23464 (from geneSymbol) ENSMUST00000083145.1 ENSMUST00000083145.2 uc290hde.1 uc290hde.2 uc290hde.1 uc290hde.2 
ENSMUST00000083146.3 Gm26497 ENSMUST00000083146.3 Gm26497 (from geneSymbol) ENSMUST00000083146.1 ENSMUST00000083146.2 LF197360 uc292dtj.1 uc292dtj.2 uc292dtj.1 uc292dtj.2 
ENSMUST00000083152.3 Gm26495 ENSMUST00000083152.3 Gm26495 (from geneSymbol) ENSMUST00000083152.1 ENSMUST00000083152.2 uc287uyx.1 uc287uyx.2 uc287uyx.1 uc287uyx.2 
ENSMUST00000083153.3 Snord22 ENSMUST00000083153.3 small nucleolar RNA, C/D box 22 (from RefSeq NR_004445.1) ENSMUST00000083153.1 ENSMUST00000083153.2 NR_004445 uc012bid.1 uc012bid.2 uc012bid.1 uc012bid.2 
ENSMUST00000083154.3 Gm24493 ENSMUST00000083154.3 Gm24493 (from geneSymbol) ENSMUST00000083154.1 ENSMUST00000083154.2 uc292ntv.1 uc292ntv.2 uc292ntv.1 uc292ntv.2 
ENSMUST00000083155.3 Gm26493 ENSMUST00000083155.3 Gm26493 (from geneSymbol) ENSMUST00000083155.1 ENSMUST00000083155.2 uc292clw.1 uc292clw.2 uc292clw.1 uc292clw.2 
ENSMUST00000083156.3 Gm23677 ENSMUST00000083156.3 Gm23677 (from geneSymbol) ENSMUST00000083156.1 ENSMUST00000083156.2 uc292diy.1 uc292diy.2 uc292diy.1 uc292diy.2 
ENSMUST00000083160.3 Snord1a ENSMUST00000083160.3 small nucleolar RNA, C/D box 1A (from RefSeq NR_028570.1) ENSMUST00000083160.1 ENSMUST00000083160.2 NR_028570 uc288dug.1 uc288dug.2 uc288dug.1 uc288dug.2 
ENSMUST00000083162.3 Gm23680 ENSMUST00000083162.3 Gm23680 (from geneSymbol) AB353021 ENSMUST00000083162.1 ENSMUST00000083162.2 uc287poj.1 uc287poj.2 uc287poj.1 uc287poj.2 
ENSMUST00000083163.3 Snora16a ENSMUST00000083163.3 small nucleolar RNA, H/ACA box 16A (from RefSeq NR_029412.1) ENSMUST00000083163.1 ENSMUST00000083163.2 NR_029412 uc012dmf.1 uc012dmf.2 uc012dmf.1 uc012dmf.2 
ENSMUST00000083166.3 Gm26132 ENSMUST00000083166.3 Gm26132 (from geneSymbol) ENSMUST00000083166.1 ENSMUST00000083166.2 uc292dfq.1 uc292dfq.2 uc292dfq.1 uc292dfq.2 
ENSMUST00000083170.3 Gm26128 ENSMUST00000083170.3 Gm26128 (from geneSymbol) DQ558729 ENSMUST00000083170.1 ENSMUST00000083170.2 uc287yzu.1 uc287yzu.2 uc287yzu.1 uc287yzu.2 
ENSMUST00000083171.3 Gm26130 ENSMUST00000083171.3 Gm26130 (from geneSymbol) ENSMUST00000083171.1 ENSMUST00000083171.2 uc289hbe.1 uc289hbe.2 uc289hbe.1 uc289hbe.2 
ENSMUST00000083173.4 n-R5s88 ENSMUST00000083173.4 n-R5s88 (from geneSymbol) ENSMUST00000083173.1 ENSMUST00000083173.2 ENSMUST00000083173.3 uc292kcg.1 uc292kcg.2 uc292kcg.1 uc292kcg.2 
ENSMUST00000083176.6 Snord61 ENSMUST00000083176.6 small nucleolar RNA, C/D box 61 (from RefSeq NR_002903.1) ENSMUST00000083176.1 ENSMUST00000083176.2 ENSMUST00000083176.3 ENSMUST00000083176.4 ENSMUST00000083176.5 NR_002903 uc009thk.1 uc009thk.2 uc009thk.3 uc009thk.1 uc009thk.2 uc009thk.3 
ENSMUST00000083177.3 Gm25141 ENSMUST00000083177.3 Gm25141 (from geneSymbol) ENSMUST00000083177.1 ENSMUST00000083177.2 uc289bvj.1 uc289bvj.2 uc289bvj.1 uc289bvj.2 
ENSMUST00000083184.3 Gm23297 ENSMUST00000083184.3 Gm23297 (from geneSymbol) ENSMUST00000083184.1 ENSMUST00000083184.2 uc291xmz.1 uc291xmz.2 uc291xmz.1 uc291xmz.2 
ENSMUST00000083188.4 Gm26126 ENSMUST00000083188.4 Gm26126 (from geneSymbol) ENSMUST00000083188.1 ENSMUST00000083188.2 ENSMUST00000083188.3 uc292jgs.1 uc292jgs.2 uc292jgs.1 uc292jgs.2 
ENSMUST00000083190.3 Snora65 ENSMUST00000083190.3 small nucleolar RNA, H/ACA box 65 (from RefSeq NR_002898.3) ENSMUST00000083190.1 ENSMUST00000083190.2 NR_002898 uc289vgq.1 uc289vgq.2 uc289vgq.1 uc289vgq.2 
ENSMUST00000083192.3 Snord104 ENSMUST00000083192.3 small nucleolar RNA, C/D box 104 (from RefSeq NR_030703.1) ENSMUST00000083192.1 ENSMUST00000083192.2 NR_030703 uc011ygj.1 uc011ygj.2 uc011ygj.3 uc011ygj.1 uc011ygj.2 uc011ygj.3 
ENSMUST00000083193.3 Gm26127 ENSMUST00000083193.3 Gm26127 (from geneSymbol) DQ558729 ENSMUST00000083193.1 ENSMUST00000083193.2 uc289vut.1 uc289vut.2 uc289vut.1 uc289vut.2 
ENSMUST00000083196.3 Gm24457 ENSMUST00000083196.3 Gm24457 (from geneSymbol) ENSMUST00000083196.1 ENSMUST00000083196.2 uc290kfh.1 uc290kfh.2 uc290kfh.1 uc290kfh.2 
ENSMUST00000083205.4 Gm24661 ENSMUST00000083205.4 Gm24661 (from geneSymbol) ENSMUST00000083205.1 ENSMUST00000083205.2 ENSMUST00000083205.3 uc289jni.1 uc289jni.2 uc289jni.1 uc289jni.2 
ENSMUST00000083207.3 Gm22652 ENSMUST00000083207.3 Gm22652 (from geneSymbol) ENSMUST00000083207.1 ENSMUST00000083207.2 uc289xii.1 uc289xii.2 uc289xii.1 uc289xii.2 
ENSMUST00000083209.3 Gm25644 ENSMUST00000083209.3 Gm25644 (from geneSymbol) ENSMUST00000083209.1 ENSMUST00000083209.2 uc289siy.1 uc289siy.2 uc289siy.1 uc289siy.2 
ENSMUST00000083213.3 Snora31 ENSMUST00000083213.3 small nucleolar RNA, H/ACA box 31 (from RefSeq NR_028481.1) ENSMUST00000083213.1 ENSMUST00000083213.2 NR_028481 uc011zoq.1 uc011zoq.2 uc011zoq.3 uc011zoq.1 uc011zoq.2 uc011zoq.3 
ENSMUST00000083215.4 n-R5s92 ENSMUST00000083215.4 n-R5s92 (from geneSymbol) ENSMUST00000083215.1 ENSMUST00000083215.2 ENSMUST00000083215.3 uc292itl.1 uc292itl.2 uc292itl.1 uc292itl.2 
ENSMUST00000083216.3 Gm22251 ENSMUST00000083216.3 Gm22251 (from geneSymbol) ENSMUST00000083216.1 ENSMUST00000083216.2 uc289odn.1 uc289odn.2 uc289odn.1 uc289odn.2 
ENSMUST00000083217.3 Gm25480 ENSMUST00000083217.3 Gm25480 (from geneSymbol) ENSMUST00000083217.1 ENSMUST00000083217.2 uc290nfk.1 uc290nfk.2 uc290nfk.1 uc290nfk.2 
ENSMUST00000083221.3 Gm25481 ENSMUST00000083221.3 Gm25481 (from geneSymbol) ENSMUST00000083221.1 ENSMUST00000083221.2 uc292nem.1 uc292nem.2 uc292nem.1 uc292nem.2 
ENSMUST00000083224.3 Gm25804 ENSMUST00000083224.3 Gm25804 (from geneSymbol) ENSMUST00000083224.1 ENSMUST00000083224.2 uc288ksx.1 uc288ksx.2 uc288ksx.1 uc288ksx.2 
ENSMUST00000083225.3 Gm25482 ENSMUST00000083225.3 Gm25482 (from geneSymbol) ENSMUST00000083225.1 ENSMUST00000083225.2 uc289sdm.1 uc289sdm.2 uc289sdm.1 uc289sdm.2 
ENSMUST00000083226.3 Gm50452 ENSMUST00000083226.3 Gm50452 (from geneSymbol) ENSMUST00000083226.1 ENSMUST00000083226.2 JF446417 uc287nci.1 uc287nci.2 uc287nci.1 uc287nci.2 
ENSMUST00000083228.3 Gm23645 ENSMUST00000083228.3 Gm23645 (from geneSymbol) ENSMUST00000083228.1 ENSMUST00000083228.2 uc288czi.1 uc288czi.2 uc288czi.1 uc288czi.2 
ENSMUST00000083230.3 Gm23814 ENSMUST00000083230.3 Gm23814 (from geneSymbol) DQ558729 ENSMUST00000083230.1 ENSMUST00000083230.2 uc289zpz.1 uc289zpz.2 uc289zpz.1 uc289zpz.2 
ENSMUST00000083231.3 Gm22747 ENSMUST00000083231.3 Gm22747 (from geneSymbol) DQ558729 ENSMUST00000083231.1 ENSMUST00000083231.2 uc291rgs.1 uc291rgs.2 uc291rgs.1 uc291rgs.2 
ENSMUST00000083232.3 Gm24018 ENSMUST00000083232.3 Gm24018 (from geneSymbol) DQ558729 ENSMUST00000083232.1 ENSMUST00000083232.2 uc288lab.1 uc288lab.2 uc288lab.1 uc288lab.2 
ENSMUST00000083239.3 Gm22127 ENSMUST00000083239.3 Gm22127 (from geneSymbol) ENSMUST00000083239.1 ENSMUST00000083239.2 uc287xkq.1 uc287xkq.2 uc287xkq.1 uc287xkq.2 
ENSMUST00000083242.3 Rnu12 ENSMUST00000083242.3 RNA U12, small nuclear (from RefSeq NR_004432.2) ENSMUST00000083242.1 ENSMUST00000083242.2 NR_004432 uc011zxb.1 uc011zxb.2 uc011zxb.3 uc011zxb.1 uc011zxb.2 uc011zxb.3 
ENSMUST00000083244.3 Gm22126 ENSMUST00000083244.3 Gm22126 (from geneSymbol) ENSMUST00000083244.1 ENSMUST00000083244.2 uc288lzp.1 uc288lzp.2 uc288lzp.1 uc288lzp.2 
ENSMUST00000083247.3 Gm25139 ENSMUST00000083247.3 Gm25139 (from geneSymbol) ENSMUST00000083247.1 ENSMUST00000083247.2 uc287pok.1 uc287pok.2 uc287pok.1 uc287pok.2 
ENSMUST00000083248.3 Gm25138 ENSMUST00000083248.3 Gm25138 (from geneSymbol) ENSMUST00000083248.1 ENSMUST00000083248.2 uc292biy.1 uc292biy.2 uc292biy.1 uc292biy.2 
ENSMUST00000083251.3 Gm25137 ENSMUST00000083251.3 Gm25137 (from geneSymbol) DQ558729 ENSMUST00000083251.1 ENSMUST00000083251.2 uc290ozj.1 uc290ozj.2 uc290ozj.1 uc290ozj.2 
ENSMUST00000083253.3 Gm25136 ENSMUST00000083253.3 Gm25136 (from geneSymbol) ENSMUST00000083253.1 ENSMUST00000083253.2 uc291jsz.1 uc291jsz.2 uc291jsz.1 uc291jsz.2 
ENSMUST00000083254.3 Gm25140 ENSMUST00000083254.3 Gm25140 (from geneSymbol) ENSMUST00000083254.1 ENSMUST00000083254.2 uc289eov.1 uc289eov.2 uc289eov.1 uc289eov.2 
ENSMUST00000083257.4 Gm23458 ENSMUST00000083257.4 Gm23458 (from geneSymbol) ENSMUST00000083257.1 ENSMUST00000083257.2 ENSMUST00000083257.3 uc290zpg.1 uc290zpg.2 uc290zpg.1 uc290zpg.2 
ENSMUST00000083258.3 Gm23460 ENSMUST00000083258.3 Gm23460 (from geneSymbol) ENSMUST00000083258.1 ENSMUST00000083258.2 uc287iao.1 uc287iao.2 uc287iao.1 uc287iao.2 
ENSMUST00000083259.4 Gm23459 ENSMUST00000083259.4 Gm23459 (from geneSymbol) ENSMUST00000083259.1 ENSMUST00000083259.2 ENSMUST00000083259.3 uc288wja.1 uc288wja.2 uc288wja.1 uc288wja.2 
ENSMUST00000083262.3 Snord85 ENSMUST00000083262.3 small nucleolar RNA, C/D box 85 (from RefSeq NR_028565.2) ENSMUST00000083262.1 ENSMUST00000083262.2 NR_028565 uc012dlw.1 uc012dlw.2 uc012dlw.3 uc012dlw.1 uc012dlw.2 uc012dlw.3 
ENSMUST00000083264.3 Gm23462 ENSMUST00000083264.3 Gm23462 (from geneSymbol) ENSMUST00000083264.1 ENSMUST00000083264.2 uc291kln.1 uc291kln.2 uc291kln.1 uc291kln.2 
ENSMUST00000083265.4 Gm23461 ENSMUST00000083265.4 Gm23461 (from geneSymbol) DQ558729 ENSMUST00000083265.1 ENSMUST00000083265.2 ENSMUST00000083265.3 uc292opi.1 uc292opi.2 uc292opi.1 uc292opi.2 
ENSMUST00000083266.3 Gm24613 ENSMUST00000083266.3 Gm24613 (from geneSymbol) ENSMUST00000083266.1 ENSMUST00000083266.2 uc288ftc.1 uc288ftc.2 uc288ftc.1 uc288ftc.2 
ENSMUST00000083268.3 Gm24615 ENSMUST00000083268.3 Gm24615 (from geneSymbol) ENSMUST00000083268.1 ENSMUST00000083268.2 uc292imd.1 uc292imd.2 uc292imd.1 uc292imd.2 
ENSMUST00000083269.3 Gm24614 ENSMUST00000083269.3 Gm24614 (from geneSymbol) DQ558729 ENSMUST00000083269.1 ENSMUST00000083269.2 uc290dtu.1 uc290dtu.2 uc290dtu.1 uc290dtu.2 
ENSMUST00000083270.3 Gm24610 ENSMUST00000083270.3 Gm24610 (from geneSymbol) ENSMUST00000083270.1 ENSMUST00000083270.2 uc289sha.1 uc289sha.2 uc289sha.1 uc289sha.2 
ENSMUST00000083272.4 Gm24611 ENSMUST00000083272.4 Gm24611 (from geneSymbol) ENSMUST00000083272.1 ENSMUST00000083272.2 ENSMUST00000083272.3 uc291dxs.1 uc291dxs.2 uc291dxs.1 uc291dxs.2 
ENSMUST00000083274.3 Gm24616 ENSMUST00000083274.3 Gm24616 (from geneSymbol) ENSMUST00000083274.1 ENSMUST00000083274.2 uc289dtp.1 uc289dtp.2 uc289dtp.1 uc289dtp.2 
ENSMUST00000083277.5 Gm26265 ENSMUST00000083277.5 Gm26265 (from geneSymbol) ENSMUST00000083277.1 ENSMUST00000083277.2 ENSMUST00000083277.3 ENSMUST00000083277.4 uc292cma.1 uc292cma.2 uc292cma.1 uc292cma.2 
ENSMUST00000083278.3 Gm26264 ENSMUST00000083278.3 Gm26264 (from geneSymbol) AB353021 ENSMUST00000083278.1 ENSMUST00000083278.2 uc291fzo.1 uc291fzo.2 uc291fzo.1 uc291fzo.2 
ENSMUST00000083281.3 Gm26263 ENSMUST00000083281.3 Gm26263 (from geneSymbol) ENSMUST00000083281.1 ENSMUST00000083281.2 uc287joa.1 uc287joa.2 uc287joa.1 uc287joa.2 
ENSMUST00000083285.3 Snord32a ENSMUST00000083285.3 small nucleolar RNA, C/D box 32A (from RefSeq NR_000002.9) ENSMUST00000083285.1 ENSMUST00000083285.2 NR_000002 uc291ppf.1 uc291ppf.2 uc291ppf.1 uc291ppf.2 
ENSMUST00000083286.3 Gm25794 ENSMUST00000083286.3 Gm25794 (from geneSymbol) DQ558729 ENSMUST00000083286.1 ENSMUST00000083286.2 uc287ssv.1 uc287ssv.2 uc287ssv.1 uc287ssv.2 
ENSMUST00000083289.4 Gm25792 ENSMUST00000083289.4 Gm25792 (from geneSymbol) ENSMUST00000083289.1 ENSMUST00000083289.2 ENSMUST00000083289.3 uc287hbp.1 uc287hbp.2 uc287hbp.1 uc287hbp.2 
ENSMUST00000083292.3 Gm25791 ENSMUST00000083292.3 Gm25791 (from geneSymbol) ENSMUST00000083292.1 ENSMUST00000083292.2 uc292ept.1 uc292ept.2 uc292ept.1 uc292ept.2 
ENSMUST00000083294.3 Gm25789 ENSMUST00000083294.3 Gm25789 (from geneSymbol) ENSMUST00000083294.1 ENSMUST00000083294.2 FM991906 uc287ncn.1 uc287ncn.2 uc287ncn.1 uc287ncn.2 
ENSMUST00000083297.3 Gm22972 ENSMUST00000083297.3 Gm22972 (from geneSymbol) ENSMUST00000083297.1 ENSMUST00000083297.2 uc292cyc.1 uc292cyc.2 uc292cyc.1 uc292cyc.2 
ENSMUST00000083298.3 Gm22973 ENSMUST00000083298.3 Gm22973 (from geneSymbol) DQ562105 ENSMUST00000083298.1 ENSMUST00000083298.2 uc288gog.1 uc288gog.2 uc288gog.1 uc288gog.2 
ENSMUST00000083299.3 n-R5s58 ENSMUST00000083299.3 n-R5s58 (from geneSymbol) ENSMUST00000083299.1 ENSMUST00000083299.2 uc288guz.1 uc288guz.2 uc288guz.1 uc288guz.2 
ENSMUST00000083301.3 Gm22974 ENSMUST00000083301.3 Gm22974 (from geneSymbol) DQ558729 ENSMUST00000083301.1 ENSMUST00000083301.2 uc290wqh.1 uc290wqh.2 uc290wqh.1 uc290wqh.2 
ENSMUST00000083302.3 n-R5s195 ENSMUST00000083302.3 n-R5s195 (from geneSymbol) AB350652 ENSMUST00000083302.1 ENSMUST00000083302.2 uc290grn.1 uc290grn.2 uc290grn.1 uc290grn.2 
ENSMUST00000083304.3 Gm22970 ENSMUST00000083304.3 Gm22970 (from geneSymbol) ENSMUST00000083304.1 ENSMUST00000083304.2 uc288wee.1 uc288wee.2 uc288wee.1 uc288wee.2 
ENSMUST00000083305.3 Gm22971 ENSMUST00000083305.3 Gm22971 (from geneSymbol) DQ558729 ENSMUST00000083305.1 ENSMUST00000083305.2 uc291hhv.1 uc291hhv.2 uc291hhv.1 uc291hhv.2 
ENSMUST00000083308.3 Gm22294 ENSMUST00000083308.3 Gm22294 (from geneSymbol) ENSMUST00000083308.1 ENSMUST00000083308.2 uc292nis.1 uc292nis.2 uc292nis.1 uc292nis.2 
ENSMUST00000083310.4 Gm22296 ENSMUST00000083310.4 Gm22296 (from geneSymbol) ENSMUST00000083310.1 ENSMUST00000083310.2 ENSMUST00000083310.3 uc288gmb.1 uc288gmb.2 uc288gmb.1 uc288gmb.2 
ENSMUST00000083312.3 Gm22297 ENSMUST00000083312.3 Gm22297 (from geneSymbol) ENSMUST00000083312.1 ENSMUST00000083312.2 LF198652 uc287zuf.1 uc287zuf.2 uc287zuf.1 uc287zuf.2 
ENSMUST00000083314.3 Gm22293 ENSMUST00000083314.3 Gm22293 (from geneSymbol) ENSMUST00000083314.1 ENSMUST00000083314.2 uc290jpa.1 uc290jpa.2 uc290jpa.1 uc290jpa.2 
ENSMUST00000083319.3 Gm23970 ENSMUST00000083319.3 Gm23970 (from geneSymbol) ENSMUST00000083319.1 ENSMUST00000083319.2 uc289tkw.1 uc289tkw.2 uc289tkw.1 uc289tkw.2 
ENSMUST00000083321.3 Gm23974 ENSMUST00000083321.3 Gm23974 (from geneSymbol) ENSMUST00000083321.1 ENSMUST00000083321.2 uc287hvk.1 uc287hvk.2 uc287hvk.1 uc287hvk.2 
ENSMUST00000083322.3 Gm23972 ENSMUST00000083322.3 Gm23972 (from geneSymbol) ENSMUST00000083322.1 ENSMUST00000083322.2 uc288mgb.1 uc288mgb.2 uc288mgb.1 uc288mgb.2 
ENSMUST00000083324.3 Gm23969 ENSMUST00000083324.3 Gm23969 (from geneSymbol) ENSMUST00000083324.1 ENSMUST00000083324.2 uc289ugn.1 uc289ugn.2 uc289ugn.1 uc289ugn.2 
ENSMUST00000083325.3 Snora30 ENSMUST00000083325.3 small nucleolar RNA, H/ACA box 30 (from RefSeq NR_034045.1) ENSMUST00000083325.1 ENSMUST00000083325.2 NR_034045 uc012fuk.1 uc012fuk.2 uc012fuk.3 uc012fuk.1 uc012fuk.2 uc012fuk.3 
ENSMUST00000083326.3 Gm23453 ENSMUST00000083326.3 Gm23453 (from geneSymbol) ENSMUST00000083326.1 ENSMUST00000083326.2 uc287hbs.1 uc287hbs.2 uc287hbs.1 uc287hbs.2 
ENSMUST00000083328.3 Gm23451 ENSMUST00000083328.3 Gm23451 (from geneSymbol) ENSMUST00000083328.1 ENSMUST00000083328.2 uc288caw.1 uc288caw.2 uc288caw.1 uc288caw.2 
ENSMUST00000083331.3 Gm23455 ENSMUST00000083331.3 Gm23455 (from geneSymbol) AK135416 ENSMUST00000083331.1 ENSMUST00000083331.2 uc292epx.1 uc292epx.2 uc292epx.1 uc292epx.2 
ENSMUST00000083332.3 Gm23454 ENSMUST00000083332.3 Gm23454 (from geneSymbol) ENSMUST00000083332.1 ENSMUST00000083332.2 uc292pkf.1 uc292pkf.2 uc292pkf.1 uc292pkf.2 
ENSMUST00000083338.3 Snord57 ENSMUST00000083338.3 small nucleolar RNA, C/D box 57 (from RefSeq NR_028528.1) ENSMUST00000083338.1 ENSMUST00000083338.2 NR_028528 uc290alu.1 uc290alu.2 uc290alu.1 uc290alu.2 
ENSMUST00000083339.3 Gm25128 ENSMUST00000083339.3 Gm25128 (from geneSymbol) ENSMUST00000083339.1 ENSMUST00000083339.2 uc289kmv.1 uc289kmv.2 uc289kmv.1 uc289kmv.2 
ENSMUST00000083340.3 Gm25125 ENSMUST00000083340.3 Gm25125 (from geneSymbol) ENSMUST00000083340.1 ENSMUST00000083340.2 uc292jhj.1 uc292jhj.2 uc292jhj.1 uc292jhj.2 
ENSMUST00000083343.3 Gm25126 ENSMUST00000083343.3 Gm25126 (from geneSymbol) ENSMUST00000083343.1 ENSMUST00000083343.2 uc291zjx.1 uc291zjx.2 uc291zjx.1 uc291zjx.2 
ENSMUST00000083345.3 Gm25124 ENSMUST00000083345.3 Gm25124 (from geneSymbol) ENSMUST00000083345.1 ENSMUST00000083345.2 uc290obs.1 uc290obs.2 uc290obs.1 uc290obs.2 
ENSMUST00000083346.3 Gm24453 ENSMUST00000083346.3 Gm24453 (from geneSymbol) ENSMUST00000083346.1 ENSMUST00000083346.2 uc289qrz.1 uc289qrz.2 uc289qrz.1 uc289qrz.2 
ENSMUST00000083347.4 Gm24452 ENSMUST00000083347.4 Gm24452 (from geneSymbol) DQ689086 ENSMUST00000083347.1 ENSMUST00000083347.2 ENSMUST00000083347.3 uc289qrx.1 uc289qrx.2 uc289qrx.1 uc289qrx.2 
ENSMUST00000083348.3 Gm24455 ENSMUST00000083348.3 Gm24455 (from geneSymbol) ENSMUST00000083348.1 ENSMUST00000083348.2 uc292epq.1 uc292epq.2 uc292epq.1 uc292epq.2 
ENSMUST00000083349.3 Gm24454 ENSMUST00000083349.3 Gm24454 (from geneSymbol) ENSMUST00000083349.1 ENSMUST00000083349.2 uc288arf.1 uc288arf.2 uc288arf.1 uc288arf.2 
ENSMUST00000083353.3 Gm24451 ENSMUST00000083353.3 Gm24451 (from geneSymbol) ENSMUST00000083353.1 ENSMUST00000083353.2 uc290alg.1 uc290alg.2 uc290alg.1 uc290alg.2 
ENSMUST00000083355.3 Gm23650 ENSMUST00000083355.3 Gm23650 (from geneSymbol) ENSMUST00000083355.1 ENSMUST00000083355.2 uc290als.1 uc290als.2 uc290als.1 uc290als.2 
ENSMUST00000083357.3 Gm26125 ENSMUST00000083357.3 Gm26125 (from geneSymbol) DQ558729 ENSMUST00000083357.1 ENSMUST00000083357.2 uc292pae.1 uc292pae.2 uc292pae.1 uc292pae.2 
ENSMUST00000083359.3 Gm26124 ENSMUST00000083359.3 Gm26124 (from geneSymbol) ENSMUST00000083359.1 ENSMUST00000083359.2 uc289mxx.1 uc289mxx.2 uc289mxx.1 uc289mxx.2 
ENSMUST00000083361.3 Gm24134 ENSMUST00000083361.3 Gm24134 (from geneSymbol) ENSMUST00000083361.1 ENSMUST00000083361.2 uc289ugq.1 uc289ugq.2 uc289ugq.1 uc289ugq.2 
ENSMUST00000083362.4 Gm26122 ENSMUST00000083362.4 Gm26122 (from geneSymbol) ENSMUST00000083362.1 ENSMUST00000083362.2 ENSMUST00000083362.3 uc287ugd.1 uc287ugd.2 uc287ugd.1 uc287ugd.2 
ENSMUST00000083363.3 Gm26123 ENSMUST00000083363.3 Gm26123 (from geneSymbol) ENSMUST00000083363.1 ENSMUST00000083363.2 uc292aha.1 uc292aha.2 uc292aha.1 uc292aha.2 
ENSMUST00000083364.3 Gm26121 ENSMUST00000083364.3 Gm26121 (from geneSymbol) ENSMUST00000083364.1 ENSMUST00000083364.2 uc287zxu.1 uc287zxu.2 uc287zxu.1 uc287zxu.2 
ENSMUST00000083365.3 Gm23138 ENSMUST00000083365.3 Gm23138 (from geneSymbol) ENSMUST00000083365.1 ENSMUST00000083365.2 uc290onp.1 uc290onp.2 uc290onp.1 uc290onp.2 
ENSMUST00000083367.3 Gm23248 ENSMUST00000083367.3 Gm23248 (from geneSymbol) DQ558729 ENSMUST00000083367.1 ENSMUST00000083367.2 uc292igq.1 uc292igq.2 uc292igq.1 uc292igq.2 
ENSMUST00000083369.4 Gm23249 ENSMUST00000083369.4 Gm23249 (from geneSymbol) ENSMUST00000083369.1 ENSMUST00000083369.2 ENSMUST00000083369.3 uc288ikm.1 uc288ikm.2 uc288ikm.1 uc288ikm.2 
ENSMUST00000083370.3 Gm23245 ENSMUST00000083370.3 Gm23245 (from geneSymbol) ENSMUST00000083370.1 ENSMUST00000083370.2 uc291adq.1 uc291adq.2 uc291adq.1 uc291adq.2 
ENSMUST00000083371.3 Gm23246 ENSMUST00000083371.3 Gm23246 (from geneSymbol) ENSMUST00000083371.1 ENSMUST00000083371.2 uc289qsh.1 uc289qsh.2 uc289qsh.1 uc289qsh.2 
ENSMUST00000083375.4 Gm23244 ENSMUST00000083375.4 Gm23244 (from geneSymbol) DQ558729 ENSMUST00000083375.1 ENSMUST00000083375.2 ENSMUST00000083375.3 uc291hrr.1 uc291hrr.2 uc291hrr.1 uc291hrr.2 
ENSMUST00000083378.3 Gm26063 ENSMUST00000083378.3 Gm26063 (from geneSymbol) ENSMUST00000083378.1 ENSMUST00000083378.2 uc288xyk.1 uc288xyk.2 uc288xyk.1 uc288xyk.2 
ENSMUST00000083380.3 Gm25332 ENSMUST00000083380.3 Gm25332 (from geneSymbol) ENSMUST00000083380.1 ENSMUST00000083380.2 uc292nld.1 uc292nld.2 uc292nld.1 uc292nld.2 
ENSMUST00000083381.3 Gm26064 ENSMUST00000083381.3 Gm26064 (from geneSymbol) ENSMUST00000083381.1 ENSMUST00000083381.2 uc288mku.1 uc288mku.2 uc288mku.1 uc288mku.2 
ENSMUST00000083385.4 Gm26066 ENSMUST00000083385.4 Gm26066 (from geneSymbol) ENSMUST00000083385.1 ENSMUST00000083385.2 ENSMUST00000083385.3 uc289nfp.1 uc289nfp.2 uc289nfp.1 uc289nfp.2 
ENSMUST00000083386.4 Gm22056 ENSMUST00000083386.4 Gm22056 (from geneSymbol) ENSMUST00000083386.1 ENSMUST00000083386.2 ENSMUST00000083386.3 uc290yne.1 uc290yne.2 uc290yne.1 uc290yne.2 
ENSMUST00000083388.2 Gm22055 ENSMUST00000083388.2 Gm22055 (from geneSymbol) DQ558729 ENSMUST00000083388.1 uc290mmk.1 uc290mmk.2 uc290mmk.1 uc290mmk.2 
ENSMUST00000083389.3 Gm24319 ENSMUST00000083389.3 Gm24319 (from geneSymbol) ENSMUST00000083389.1 ENSMUST00000083389.2 uc289rhr.1 uc289rhr.2 uc289rhr.1 uc289rhr.2 
ENSMUST00000083394.4 Gm22053 ENSMUST00000083394.4 Gm22053 (from geneSymbol) ENSMUST00000083394.1 ENSMUST00000083394.2 ENSMUST00000083394.3 LF205002 uc288qsr.1 uc288qsr.2 uc288qsr.1 uc288qsr.2 
ENSMUST00000083395.4 Gm22054 ENSMUST00000083395.4 Gm22054 (from geneSymbol) ENSMUST00000083395.1 ENSMUST00000083395.2 ENSMUST00000083395.3 uc290tpc.1 uc290tpc.2 uc290tpc.1 uc290tpc.2 
ENSMUST00000083397.3 Gm24927 ENSMUST00000083397.3 Gm24927 (from geneSymbol) DQ558729 ENSMUST00000083397.1 ENSMUST00000083397.2 uc289cwe.1 uc289cwe.2 uc289cwe.1 uc289cwe.2 
ENSMUST00000083399.3 Gm24928 ENSMUST00000083399.3 Gm24928 (from geneSymbol) ENSMUST00000083399.1 ENSMUST00000083399.2 uc289dvs.1 uc289dvs.2 uc289dvs.1 uc289dvs.2 
ENSMUST00000083403.3 Gm24929 ENSMUST00000083403.3 Gm24929 (from geneSymbol) ENSMUST00000083403.1 ENSMUST00000083403.2 uc291zwn.1 uc291zwn.2 uc291zwn.1 uc291zwn.2 
ENSMUST00000083406.3 Gm25578 ENSMUST00000083406.3 Gm25578 (from geneSymbol) ENSMUST00000083406.1 ENSMUST00000083406.2 uc287lhw.1 uc287lhw.2 uc287lhw.1 uc287lhw.2 
ENSMUST00000083407.3 Gm25579 ENSMUST00000083407.3 Gm25579 (from geneSymbol) ENSMUST00000083407.1 ENSMUST00000083407.2 uc291vkt.1 uc291vkt.2 uc291vkt.1 uc291vkt.2 
ENSMUST00000083410.2 Gm25581 ENSMUST00000083410.2 Gm25581 (from geneSymbol) DQ548138 ENSMUST00000083410.1 uc290luc.1 uc290luc.2 uc290luc.1 uc290luc.2 
ENSMUST00000083412.4 Gm25582 ENSMUST00000083412.4 Gm25582 (from geneSymbol) ENSMUST00000083412.1 ENSMUST00000083412.2 ENSMUST00000083412.3 LF197742 uc292jsg.1 uc292jsg.2 uc292jsg.1 uc292jsg.2 
ENSMUST00000083419.3 Snora73b ENSMUST00000083419.3 small nucleolar RNA, H/ACA box 73b (from RefSeq NR_028513.1) ENSMUST00000083419.1 ENSMUST00000083419.2 NR_028513 uc057lkg.1 uc057lkg.2 uc057lkg.1 uc057lkg.2 
ENSMUST00000083424.3 Snord14c ENSMUST00000083424.3 small nucleolar RNA, C/D box 14C (from RefSeq NR_028276.2) ENSMUST00000083424.1 ENSMUST00000083424.2 NR_028276 uc057lzj.1 uc057lzj.2 uc057lzj.3 uc057lzj.1 uc057lzj.2 uc057lzj.3 
ENSMUST00000083425.3 Gm23136 ENSMUST00000083425.3 Gm23136 (from geneSymbol) ENSMUST00000083425.1 ENSMUST00000083425.2 uc292icf.1 uc292icf.2 uc292icf.1 uc292icf.2 
ENSMUST00000083426.3 Gm24412 ENSMUST00000083426.3 Gm24412 (from geneSymbol) ENSMUST00000083426.1 ENSMUST00000083426.2 uc291sul.1 uc291sul.2 uc291sul.1 uc291sul.2 
ENSMUST00000083428.3 Gm24411 ENSMUST00000083428.3 Gm24411 (from geneSymbol) ENSMUST00000083428.1 ENSMUST00000083428.2 uc290ccy.1 uc290ccy.2 uc290ccy.1 uc290ccy.2 
ENSMUST00000083433.3 Gm24410 ENSMUST00000083433.3 Gm24410 (from geneSymbol) ENSMUST00000083433.1 ENSMUST00000083433.2 uc291zcu.1 uc291zcu.2 uc291zcu.1 uc291zcu.2 
ENSMUST00000083435.3 Gm26244 ENSMUST00000083435.3 Gm26244 (from geneSymbol) AK134035 ENSMUST00000083435.1 ENSMUST00000083435.2 uc289nxu.1 uc289nxu.2 uc289nxu.1 uc289nxu.2 
ENSMUST00000083437.3 Gm22739 ENSMUST00000083437.3 Gm22739 (from geneSymbol) DQ548138 ENSMUST00000083437.1 ENSMUST00000083437.2 uc287phc.1 uc287phc.2 uc287phc.1 uc287phc.2 
ENSMUST00000083438.3 Gm22741 ENSMUST00000083438.3 Gm22741 (from geneSymbol) ENSMUST00000083438.1 ENSMUST00000083438.2 uc289dnz.1 uc289dnz.2 uc289dnz.1 uc289dnz.2 
ENSMUST00000083439.3 Gm22740 ENSMUST00000083439.3 Gm22740 (from geneSymbol) ENSMUST00000083439.1 ENSMUST00000083439.2 uc290ykn.1 uc290ykn.2 uc290ykn.1 uc290ykn.2 
ENSMUST00000083440.3 Gm22738 ENSMUST00000083440.3 Gm22738 (from geneSymbol) AK047968 ENSMUST00000083440.1 ENSMUST00000083440.2 uc288uwd.1 uc288uwd.2 uc288uwd.1 uc288uwd.2 
ENSMUST00000083444.3 Gm22744 ENSMUST00000083444.3 Gm22744 (from geneSymbol) ENSMUST00000083444.1 ENSMUST00000083444.2 FM991910 uc289qsc.1 uc289qsc.2 uc289qsc.1 uc289qsc.2 
ENSMUST00000083445.3 Gm22743 ENSMUST00000083445.3 Gm22743 (from geneSymbol) ENSMUST00000083445.1 ENSMUST00000083445.2 uc288cvh.1 uc288cvh.2 uc288cvh.1 uc288cvh.2 
ENSMUST00000083446.3 Gm23095 ENSMUST00000083446.3 Gm23095 (from geneSymbol) ENSMUST00000083446.1 ENSMUST00000083446.2 uc289rry.1 uc289rry.2 uc289rry.1 uc289rry.2 
ENSMUST00000083448.2 Gm23097 ENSMUST00000083448.2 Gm23097 (from geneSymbol) DQ558729 ENSMUST00000083448.1 uc292eht.1 uc292eht.2 uc292eht.1 uc292eht.2 
ENSMUST00000083450.4 Gm23093 ENSMUST00000083450.4 Gm23093 (from geneSymbol) ENSMUST00000083450.1 ENSMUST00000083450.2 ENSMUST00000083450.3 uc287wtv.1 uc287wtv.2 uc287wtv.1 uc287wtv.2 
ENSMUST00000083453.4 Gm55596 ENSMUST00000083453.4 Gm55596 (from geneSymbol) ENSMUST00000083453.1 ENSMUST00000083453.2 ENSMUST00000083453.3 uc292igi.1 uc292igi.2 uc292igi.1 uc292igi.2 
ENSMUST00000083454.3 Gm23099 ENSMUST00000083454.3 Gm23099 (from geneSymbol) ENSMUST00000083454.1 ENSMUST00000083454.2 uc291mkb.1 uc291mkb.2 uc291mkb.1 uc291mkb.2 
ENSMUST00000083455.3 Gm23100 ENSMUST00000083455.3 Gm23100 (from geneSymbol) ENSMUST00000083455.1 ENSMUST00000083455.2 uc291uki.1 uc291uki.2 uc291uki.1 uc291uki.2 
ENSMUST00000083458.3 Gm25894 ENSMUST00000083458.3 Gm25894 (from geneSymbol) ENSMUST00000083458.1 ENSMUST00000083458.2 uc289qrt.1 uc289qrt.2 uc289qrt.1 uc289qrt.2 
ENSMUST00000083460.3 Mir25 ENSMUST00000083460.3 microRNA 25 (from RefSeq NR_029787.1) ENSMUST00000083460.1 ENSMUST00000083460.2 NR_029787 uc012efg.1 uc012efg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608617.1 [ECO:0000345] ##Evidence-Data-END## uc012efg.1 uc012efg.2 
ENSMUST00000083461.3 Mir193a ENSMUST00000083461.3 microRNA 193a (from RefSeq NR_029579.1) ENSMUST00000083461.1 ENSMUST00000083461.2 NR_029579 uc011yan.1 uc011yan.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608315.1 [ECO:0000345] ##Evidence-Data-END## uc011yan.1 uc011yan.2 
ENSMUST00000083462.3 Mir99b ENSMUST00000083462.3 microRNA 99b (from RefSeq NR_029536.1) ENSMUST00000083462.1 ENSMUST00000083462.2 NR_029536 uc012ala.1 uc012ala.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608230.1 [ECO:0000345] ##Evidence-Data-END## uc012ala.1 uc012ala.2 
ENSMUST00000083463.3 Mir155 ENSMUST00000083463.3 microRNA 155 (from RefSeq NR_029565.1) ENSMUST00000083463.1 ENSMUST00000083463.2 NR_029565 uc012ahl.1 uc012ahl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608259.1 [ECO:0000345] ##Evidence-Data-END## uc012ahl.1 uc012ahl.2 
ENSMUST00000083464.3 Mir188 ENSMUST00000083464.3 microRNA 188 (from RefSeq NR_029574.1) ENSMUST00000083464.1 ENSMUST00000083464.2 NR_029574 uc012heb.1 uc012heb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608310.1 [ECO:0000345] ##Evidence-Data-END## uc012heb.1 uc012heb.2 
ENSMUST00000083465.3 Mir133a-1 ENSMUST00000083465.3 microRNA 133a-1 (from RefSeq NR_029547.1) ENSMUST00000083465.1 ENSMUST00000083465.2 NR_029547 uc012azf.1 uc012azf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608241.1 [ECO:0000345] ##Evidence-Data-END## uc012azf.1 uc012azf.2 
ENSMUST00000083466.3 Mir200a ENSMUST00000083466.3 microRNA 200a (from RefSeq NR_029723.1) ENSMUST00000083466.1 ENSMUST00000083466.2 NR_029723 uc012dre.1 uc012dre.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608552.1 [ECO:0000345] ##Evidence-Data-END## uc012dre.1 uc012dre.2 
ENSMUST00000083467.3 Mir144 ENSMUST00000083467.3 microRNA 144 (from RefSeq NR_029556.1) ENSMUST00000083467.1 ENSMUST00000083467.2 NR_029556 uc007khz.1 uc007khz.2 uc007khz.3 uc007khz.4 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608250.1 [ECO:0000345] ##Evidence-Data-END## uc007khz.1 uc007khz.2 uc007khz.3 uc007khz.4 
ENSMUST00000083468.3 Mir122 ENSMUST00000083468.3 microRNA 122 (from RefSeq NR_029600.1) ENSMUST00000083468.1 ENSMUST00000083468.2 NR_029600 uc012bec.1 uc012bec.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608333.1, SRR5189682.82616.1 [ECO:0000345] ##Evidence-Data-END## uc012bec.1 uc012bec.2 
ENSMUST00000083469.3 Mir18 ENSMUST00000083469.3 microRNA 18 (from RefSeq NR_029736.1) ENSMUST00000083469.1 ENSMUST00000083469.2 NR_029736 uc011zpu.1 uc011zpu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608565.1 [ECO:0000345] ##Evidence-Data-END## uc011zpu.1 uc011zpu.2 
ENSMUST00000083470.3 Mir201 ENSMUST00000083470.3 microRNA 201 (from RefSeq NR_029588.1) ENSMUST00000083470.1 ENSMUST00000083470.2 NR_029588 uc012hjc.1 uc012hjc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM608323.1 [ECO:0000345] ##Evidence-Data-END## uc012hjc.1 uc012hjc.2 
ENSMUST00000083471.5 Mir30a ENSMUST00000083471.5 microRNA 30a (from RefSeq NR_029533.1) ENSMUST00000083471.1 ENSMUST00000083471.2 ENSMUST00000083471.3 ENSMUST00000083471.4 NR_029533 uc011wip.1 uc011wip.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608227.1 [ECO:0000345] ##Evidence-Data-END## uc011wip.1 uc011wip.2 
ENSMUST00000083472.5 Mirlet7i ENSMUST00000083472.5 microRNA let7i (from RefSeq NR_029527.1) ENSMUST00000083472.1 ENSMUST00000083472.2 ENSMUST00000083472.3 ENSMUST00000083472.4 NR_029527 uc011xpd.1 uc011xpd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608221.1 [ECO:0000345] ##Evidence-Data-END## uc011xpd.1 uc011xpd.2 
ENSMUST00000083473.3 Mir135a-1 ENSMUST00000083473.3 microRNA 135a-1 (from RefSeq NR_029549.1) ENSMUST00000083473.1 ENSMUST00000083473.2 NR_029549 uc009rjb.1 uc009rjb.2 uc009rjb.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608243.1 [ECO:0000345] ##Evidence-Data-END## uc009rjb.1 uc009rjb.2 uc009rjb.3 
ENSMUST00000083474.3 Mir31 ENSMUST00000083474.3 microRNA 31 (from RefSeq NR_029747.1) ENSMUST00000083474.1 ENSMUST00000083474.2 NR_029747 uc012dgx.1 uc012dgx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608576.1 [ECO:0000345] ##Evidence-Data-END## uc012dgx.1 uc012dgx.2 
ENSMUST00000083475.3 Mir30e ENSMUST00000083475.3 microRNA 30e (from RefSeq NR_029602.1) ENSMUST00000083475.1 ENSMUST00000083475.2 NR_029602 uc012dkn.1 uc012dkn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc012dkn.1 uc012dkn.2 
ENSMUST00000083476.3 Mir298 ENSMUST00000083476.3 microRNA 298 (from RefSeq NR_029649.1) ENSMUST00000083476.1 ENSMUST00000083476.2 NR_029649 uc012ckv.1 uc012ckv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608440.1 [ECO:0000345] ##Evidence-Data-END## uc012ckv.1 uc012ckv.2 
ENSMUST00000083477.4 Mir195a ENSMUST00000083477.4 microRNA 195a (from RefSeq NR_029581.1) ENSMUST00000083477.1 ENSMUST00000083477.2 ENSMUST00000083477.3 NR_029581 uc011xxq.1 uc011xxq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608317.1 [ECO:0000345] ##Evidence-Data-END## uc011xxq.1 uc011xxq.2 
ENSMUST00000083478.5 Mir29b-2 ENSMUST00000083478.5 microRNA 29b-2 (from RefSeq NR_029809.1) ENSMUST00000083478.1 ENSMUST00000083478.2 ENSMUST00000083478.3 ENSMUST00000083478.4 NR_029809 uc011wzf.1 uc011wzf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608639.1 [ECO:0000345] ##Evidence-Data-END## uc011wzf.1 uc011wzf.2 
ENSMUST00000083479.4 Mir367 ENSMUST00000083479.4 microRNA 367 (from RefSeq NR_030268.1) ENSMUST00000083479.1 ENSMUST00000083479.2 ENSMUST00000083479.3 NR_030268 uc012cxl.1 uc012cxl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609538.1 [ECO:0000345] ##Evidence-Data-END## uc012cxl.1 uc012cxl.2 
ENSMUST00000083480.3 Mir138-1 ENSMUST00000083480.3 microRNA 138-1 (from RefSeq NR_029819.1) ENSMUST00000083480.1 ENSMUST00000083480.2 NR_029819 uc012hcx.1 uc012hcx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608649.1 [ECO:0000345] ##Evidence-Data-END## uc012hcx.1 uc012hcx.2 
ENSMUST00000083481.3 Mir217 ENSMUST00000083481.3 microRNA 217 (from RefSeq NR_029828.1) ENSMUST00000083481.1 ENSMUST00000083481.2 NR_029828 uc011xsn.1 uc011xsn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608658.1 [ECO:0000345] ##Evidence-Data-END## uc011xsn.1 uc011xsn.2 
ENSMUST00000083482.3 Mir19a ENSMUST00000083482.3 microRNA 19a (from RefSeq NR_029786.1) ENSMUST00000083482.1 ENSMUST00000083482.2 NR_029786 uc011zpv.1 uc011zpv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608616.1 [ECO:0000345] ##Evidence-Data-END## uc011zpv.1 uc011zpv.2 
ENSMUST00000083483.3 Mir340 ENSMUST00000083483.3 microRNA 340 (from RefSeq NR_029769.1) ENSMUST00000083483.1 ENSMUST00000083483.2 NR_029769 uc011xuf.1 uc011xuf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608598.1 [ECO:0000345] ##Evidence-Data-END## uc011xuf.1 uc011xuf.2 
ENSMUST00000083484.3 Mir322 ENSMUST00000083484.3 microRNA 322 (from RefSeq NR_029756.1) ENSMUST00000083484.1 ENSMUST00000083484.2 NR_029756 uc012hhp.1 uc012hhp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608585.1 [ECO:0000345] ##Evidence-Data-END## uc012hhp.1 uc012hhp.2 
ENSMUST00000083485.5 Mir300 ENSMUST00000083485.5 microRNA 300 (from RefSeq NR_029651.1) ENSMUST00000083485.1 ENSMUST00000083485.2 ENSMUST00000083485.3 ENSMUST00000083485.4 NR_029651 uc011ytr.1 uc011ytr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608442.1 [ECO:0000345] ##Evidence-Data-END## uc011ytr.1 uc011ytr.2 
ENSMUST00000083486.4 Mir142b ENSMUST00000083486.4 microRNA 142b (from RefSeq NR_106176.1) ENSMUST00000083486.1 ENSMUST00000083486.2 ENSMUST00000083486.3 NR_106176 uc033fzd.1 uc033fzd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fzd.1 uc033fzd.2 
ENSMUST00000083487.5 Mirlet7a-1 ENSMUST00000083487.5 microRNA let7a-1 (from RefSeq NR_029725.1) ENSMUST00000083487.1 ENSMUST00000083487.2 ENSMUST00000083487.3 ENSMUST00000083487.4 NR_029725 uc011yzd.1 uc011yzd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608554.1 [ECO:0000345] ##Evidence-Data-END## uc011yzd.1 uc011yzd.2 
ENSMUST00000083488.3 Mir221 ENSMUST00000083488.3 microRNA 221 (from RefSeq NR_029806.1) ENSMUST00000083488.1 ENSMUST00000083488.2 NR_029806 uc012hfc.1 uc012hfc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608636.1 [ECO:0000345] ##Evidence-Data-END## uc012hfc.1 uc012hfc.2 
ENSMUST00000083489.3 Mir181a-2 ENSMUST00000083489.3 microRNA 181a-2 (from RefSeq NR_029568.1) ENSMUST00000083489.1 ENSMUST00000083489.2 NR_029568 uc012buv.1 uc012buv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608303.1, SRR1660819.83561.1 [ECO:0000345] ##Evidence-Data-END## uc012buv.1 uc012buv.2 
ENSMUST00000083490.4 Mir9-2 ENSMUST00000083490.4 microRNA 9-2 (from RefSeq NR_029545.1) ENSMUST00000083490.1 ENSMUST00000083490.2 ENSMUST00000083490.3 NR_029545 uc011zch.1 uc011zch.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608239.1 [ECO:0000345] ##Evidence-Data-END## uc011zch.1 uc011zch.2 
ENSMUST00000083491.3 Mir325 ENSMUST00000083491.3 microRNA 325 (from RefSeq NR_029759.1) ENSMUST00000083491.1 ENSMUST00000083491.2 NR_029759 uc057asm.1 uc057asm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc057asm.1 uc057asm.2 
ENSMUST00000083492.5 Mir134 ENSMUST00000083492.5 microRNA 134 (from RefSeq NR_029548.1) ENSMUST00000083492.1 ENSMUST00000083492.2 ENSMUST00000083492.3 ENSMUST00000083492.4 NR_029548 uc011yty.1 uc011yty.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608242.1 [ECO:0000345] ##Evidence-Data-END## uc011yty.1 uc011yty.2 
ENSMUST00000083493.3 Mir429 ENSMUST00000083493.3 microRNA 429 (from RefSeq NR_029958.1) ENSMUST00000083493.1 ENSMUST00000083493.2 NR_029958 uc012drd.1 uc012drd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609020.1 [ECO:0000345] ##Evidence-Data-END## uc012drd.1 uc012drd.2 
ENSMUST00000083494.6 Mir382 ENSMUST00000083494.6 microRNA 382 (from RefSeq NR_029883.1) ENSMUST00000083494.1 ENSMUST00000083494.2 ENSMUST00000083494.3 ENSMUST00000083494.4 ENSMUST00000083494.5 NR_029883 uc011ytx.1 uc011ytx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608717.1 [ECO:0000345] ##Evidence-Data-END## uc011ytx.1 uc011ytx.2 
ENSMUST00000083495.3 Mir345 ENSMUST00000083495.3 microRNA 345 (from RefSeq NR_029773.1) ENSMUST00000083495.1 ENSMUST00000083495.2 NR_029773 uc011yrw.1 uc011yrw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608602.1 [ECO:0000345] ##Evidence-Data-END## uc011yrw.1 uc011yrw.2 
ENSMUST00000083496.3 Mir26a-2 ENSMUST00000083496.3 microRNA 26a-2 (from RefSeq NR_029803.1) ENSMUST00000083496.1 ENSMUST00000083496.2 NR_029803 uc011xpi.1 uc011xpi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608633.1 [ECO:0000345] ##Evidence-Data-END## uc011xpi.1 uc011xpi.2 
ENSMUST00000083497.3 Mir186 ENSMUST00000083497.3 microRNA 186 (from RefSeq NR_029572.1) ENSMUST00000083497.1 ENSMUST00000083497.2 NR_029572 uc012czz.1 uc012czz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608308.1 [ECO:0000345] ##Evidence-Data-END## uc012czz.1 uc012czz.2 
ENSMUST00000083498.3 Mir208a ENSMUST00000083498.3 microRNA 208a (from RefSeq NR_029724.1) ENSMUST00000083498.1 ENSMUST00000083498.2 NR_029724 uc011zli.1 uc011zli.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608553.1 [ECO:0000345] ##Evidence-Data-END## uc011zli.1 uc011zli.2 
ENSMUST00000083499.3 Mir370 ENSMUST00000083499.3 microRNA 370 (from RefSeq NR_029918.1) ENSMUST00000083499.1 ENSMUST00000083499.2 NR_029918 uc011yss.1 uc011yss.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608807.1 [ECO:0000345] ##Evidence-Data-END## uc011yss.1 uc011yss.2 
ENSMUST00000083500.3 Mir7-1 ENSMUST00000083500.3 microRNA 7-1 (from RefSeq NR_029825.1) ENSMUST00000083500.1 ENSMUST00000083500.2 NR_029825 uc011zap.1 uc011zap.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608655.1 [ECO:0000345] ##Evidence-Data-END## uc011zap.1 uc011zap.2 
ENSMUST00000083501.3 Mir135b ENSMUST00000083501.3 microRNA 135b (from RefSeq NR_029777.1) ENSMUST00000083501.1 ENSMUST00000083501.2 NR_029777 uc011wrv.1 uc011wrv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608606.1 [ECO:0000345] ##Evidence-Data-END## uc011wrv.1 uc011wrv.2 
ENSMUST00000083502.3 Mir342 ENSMUST00000083502.3 microRNA 342 (from RefSeq NR_029771.1) ENSMUST00000083502.1 ENSMUST00000083502.2 NR_029771 uc056ysf.1 uc056ysf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc056ysf.1 uc056ysf.2 
ENSMUST00000083503.3 Mir30d ENSMUST00000083503.3 microRNA 30d (from RefSeq NR_029718.1) ENSMUST00000083503.1 ENSMUST00000083503.2 NR_029718 uc011ztq.1 uc011ztq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608547.1 [ECO:0000345] ##Evidence-Data-END## uc011ztq.1 uc011ztq.2 
ENSMUST00000083504.4 Mir377 ENSMUST00000083504.4 microRNA 377 (from RefSeq NR_029878.1) ENSMUST00000083504.1 ENSMUST00000083504.2 ENSMUST00000083504.3 NR_029878 uc011yuf.1 uc011yuf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608712.1 [ECO:0000345] ##Evidence-Data-END## uc011yuf.1 uc011yuf.2 
ENSMUST00000083505.3 Mir140 ENSMUST00000083505.3 microRNA 140 (from RefSeq NR_029553.1) ENSMUST00000083505.1 ENSMUST00000083505.2 NR_029553 uc012gkf.1 uc012gkf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608247.1 [ECO:0000345] ##Evidence-Data-END## uc012gkf.1 uc012gkf.2 
ENSMUST00000083506.3 Mirlet7g ENSMUST00000083506.3 microRNA let7g (from RefSeq NR_029526.1) ENSMUST00000083506.1 ENSMUST00000083506.2 NR_029526 uc012gzr.1 uc012gzr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608220.1 [ECO:0000345] ##Evidence-Data-END## uc012gzr.1 uc012gzr.2 
ENSMUST00000083507.4 Mir128-2 ENSMUST00000083507.4 microRNA 128-2 (from RefSeq NR_029823.1) ENSMUST00000083507.1 ENSMUST00000083507.2 ENSMUST00000083507.3 NR_029823 uc012hbt.1 uc012hbt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608653.1 [ECO:0000345] ##Evidence-Data-END## uc012hbt.1 uc012hbt.2 
ENSMUST00000083508.3 Mir20a ENSMUST00000083508.3 microRNA 20a (from RefSeq NR_029737.1) ENSMUST00000083508.1 ENSMUST00000083508.2 NR_029737 uc011zpw.1 uc011zpw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608566.1 [ECO:0000345] ##Evidence-Data-END## uc011zpw.1 uc011zpw.2 
ENSMUST00000083509.3 Mir196b ENSMUST00000083509.3 microRNA 196b (from RefSeq NR_029912.1) ENSMUST00000083509.1 ENSMUST00000083509.2 NR_029912 uc012elz.1 uc012elz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608801.1 [ECO:0000345] ##Evidence-Data-END## uc012elz.1 uc012elz.2 
ENSMUST00000083510.3 Mir27a ENSMUST00000083510.3 microRNA 27a (from RefSeq NR_029746.1) ENSMUST00000083510.1 ENSMUST00000083510.2 NR_029746 uc012ghe.1 uc012ghe.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608575.1 [ECO:0000345] ##Evidence-Data-END## uc012ghe.1 uc012ghe.2 
ENSMUST00000083511.5 Mir143 ENSMUST00000083511.5 microRNA 143 (from RefSeq NR_029601.1) ENSMUST00000083511.1 ENSMUST00000083511.2 ENSMUST00000083511.3 ENSMUST00000083511.4 NR_029601 uc012bdr.1 uc012bdr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608334.1 [ECO:0000345] ##Evidence-Data-END## uc012bdr.1 uc012bdr.2 
ENSMUST00000083512.3 Mir139 ENSMUST00000083512.3 microRNA 139 (from RefSeq NR_029791.1) ENSMUST00000083512.1 ENSMUST00000083512.2 NR_029791 uc012fql.1 uc012fql.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608621.1 [ECO:0000345] ##Evidence-Data-END## uc012fql.1 uc012fql.2 
ENSMUST00000083513.3 Mir302d ENSMUST00000083513.3 microRNA 302d (from RefSeq NR_030405.1) ENSMUST00000083513.1 ENSMUST00000083513.2 NR_030405 uc012cxk.1 uc012cxk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609617.1 [ECO:0000345] ##Evidence-Data-END## uc012cxk.1 uc012cxk.2 
ENSMUST00000083514.4 Mir154 ENSMUST00000083514.4 microRNA 154 (from RefSeq NR_029564.1) ENSMUST00000083514.1 ENSMUST00000083514.2 ENSMUST00000083514.3 NR_029564 uc011yud.1 uc011yud.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608258.1 [ECO:0000345] ##Evidence-Data-END## uc011yud.1 uc011yud.2 
ENSMUST00000083515.3 Mir365-1 ENSMUST00000083515.3 microRNA 365-1 (from RefSeq NR_029855.1) ENSMUST00000083515.1 ENSMUST00000083515.2 NR_029855 uc012abi.1 uc012abi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608691.1 [ECO:0000345] ##Evidence-Data-END## uc012abi.1 uc012abi.2 
ENSMUST00000083516.3 Mir448 ENSMUST00000083516.3 microRNA 448 (from RefSeq NR_029956.1) ENSMUST00000083516.1 ENSMUST00000083516.2 NR_029956 uc012hqd.1 uc012hqd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609018.1 [ECO:0000345] ##Evidence-Data-END## uc012hqd.1 uc012hqd.2 
ENSMUST00000083517.3 Mir101a ENSMUST00000083517.3 microRNA 101a (from RefSeq NR_029537.1) ENSMUST00000083517.1 ENSMUST00000083517.2 NR_029537 uc012dhk.1 uc012dhk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608231.1 [ECO:0000345] ##Evidence-Data-END## uc012dhk.1 uc012dhk.2 
ENSMUST00000083518.2 Mir207 ENSMUST00000083518.2 microRNA 207 (from RefSeq NR_029594.1) ENSMUST00000083518.1 NR_029594 uc012dbw.1 uc012dbw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc012dbw.1 uc012dbw.2 
ENSMUST00000083519.3 Mirlet7d ENSMUST00000083519.3 microRNA let7d (from RefSeq NR_029656.1) ENSMUST00000083519.1 ENSMUST00000083519.2 NR_029656 uc011yzb.1 uc011yzb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608447.1 [ECO:0000345] ##Evidence-Data-END## uc011yzb.1 uc011yzb.2 
ENSMUST00000083520.4 Mir124a-3 ENSMUST00000083520.4 microRNA 124a-3 (from RefSeq NR_029538.1) ENSMUST00000083520.1 ENSMUST00000083520.2 ENSMUST00000083520.3 NR_029538 uc012cmf.1 uc012cmf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608232.1 [ECO:0000345] ##Evidence-Data-END## uc012cmf.1 uc012cmf.2 
ENSMUST00000083521.3 Mir21a ENSMUST00000083521.3 microRNA 21a (from RefSeq NR_029738.1) ENSMUST00000083521.1 ENSMUST00000083521.2 NR_029738 uc011ybs.1 uc011ybs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608567.1 [ECO:0000345] ##Evidence-Data-END## uc011ybs.1 uc011ybs.2 
ENSMUST00000083522.3 Mir106a ENSMUST00000083522.3 microRNA 106a (from RefSeq NR_029657.1) ENSMUST00000083522.1 ENSMUST00000083522.2 NR_029657 uc012hhi.1 uc012hhi.2 uc012hhi.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608448.1 [ECO:0000345] ##Evidence-Data-END## uc012hhi.1 uc012hhi.2 uc012hhi.3 
ENSMUST00000083523.5 Mir383 ENSMUST00000083523.5 microRNA 383 (from RefSeq NR_029884.1) ENSMUST00000083523.1 ENSMUST00000083523.2 ENSMUST00000083523.3 ENSMUST00000083523.4 NR_029884 uc012gcl.1 uc012gcl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608718.1 [ECO:0000345] ##Evidence-Data-END## uc012gcl.1 uc012gcl.2 
ENSMUST00000083524.3 Mir181b-1 ENSMUST00000083524.3 microRNA 181b-1 (from RefSeq NR_029820.1) ENSMUST00000083524.1 ENSMUST00000083524.2 NR_029820 uc287mef.1 uc287mef.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608650.1, AK053260.1 [ECO:0000345] ##Evidence-Data-END## uc287mef.1 uc287mef.2 
ENSMUST00000083526.3 Mir133a-2 ENSMUST00000083526.3 microRNA 133a-2 (from RefSeq NR_029901.1) ENSMUST00000083526.1 ENSMUST00000083526.2 NR_029901 uc012cmc.1 uc012cmc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608737.1 [ECO:0000345] ##Evidence-Data-END## uc012cmc.1 uc012cmc.2 
ENSMUST00000083528.5 Mir200c ENSMUST00000083528.5 microRNA 200c (from RefSeq NR_029792.1) ENSMUST00000083528.1 ENSMUST00000083528.2 ENSMUST00000083528.3 ENSMUST00000083528.4 NR_029792 uc012esn.1 uc012esn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608622.1 [ECO:0000345] ##Evidence-Data-END## uc012esn.1 uc012esn.2 
ENSMUST00000083529.3 Snord45c ENSMUST00000083529.3 small nucleolar RNA, C/D box 45C (from RefSeq NR_028525.1) ENSMUST00000083529.1 ENSMUST00000083529.2 NR_028525 uc290ksl.1 uc290ksl.2 uc290ksl.1 uc290ksl.2 
ENSMUST00000083530.4 Mir185 ENSMUST00000083530.4 microRNA 185 (from RefSeq NR_029571.1) ENSMUST00000083530.1 ENSMUST00000083530.2 ENSMUST00000083530.3 NR_029571 uc012ace.1 uc012ace.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608307.1 [ECO:0000345] ##Evidence-Data-END## uc012ace.1 uc012ace.2 
ENSMUST00000083531.3 Mir33 ENSMUST00000083531.3 microRNA 33 (from RefSeq NR_029804.1) ENSMUST00000083531.1 ENSMUST00000083531.2 NR_029804 uc011zws.1 uc011zws.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608634.1 [ECO:0000345] ##Evidence-Data-END## uc011zws.1 uc011zws.2 
ENSMUST00000083534.3 Mir26b ENSMUST00000083534.3 microRNA 26b (from RefSeq NR_029743.1) ENSMUST00000083534.1 ENSMUST00000083534.2 NR_029743 uc007bma.1 uc007bma.2 uc007bma.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608572.1 [ECO:0000345] ##Evidence-Data-END## uc007bma.1 uc007bma.2 uc007bma.3 
ENSMUST00000083535.3 Mir129-1 ENSMUST00000083535.3 microRNA 129-1 (from RefSeq NR_029567.1) ENSMUST00000083535.1 ENSMUST00000083535.2 NR_029567 uc012eiv.1 uc012eiv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608302.1 [ECO:0000345] ##Evidence-Data-END## uc012eiv.1 uc012eiv.2 
ENSMUST00000083536.3 Mir149 ENSMUST00000083536.3 microRNA 149 (from RefSeq NR_029559.1) ENSMUST00000083536.1 ENSMUST00000083536.2 NR_029559 uc011wpk.1 uc011wpk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608253.1 [ECO:0000345] ##Evidence-Data-END## uc011wpk.1 uc011wpk.2 
ENSMUST00000083537.3 Mir222 ENSMUST00000083537.3 microRNA 222 (from RefSeq NR_029807.1) ENSMUST00000083537.1 ENSMUST00000083537.2 NR_029807 uc012hfd.1 uc012hfd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608637.1 [ECO:0000345] ##Evidence-Data-END## uc012hfd.1 uc012hfd.2 
ENSMUST00000083538.3 Mir125b-2 ENSMUST00000083538.3 microRNA 125b-2 (from RefSeq NR_029540.1) ENSMUST00000083538.1 ENSMUST00000083538.2 NR_029540 uc012ahf.1 uc012ahf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608234.1 [ECO:0000345] ##Evidence-Data-END## uc012ahf.1 uc012ahf.2 
ENSMUST00000083539.3 Mir19b-2 ENSMUST00000083539.3 microRNA 19b-2 (from RefSeq NR_029715.1) ENSMUST00000083539.1 ENSMUST00000083539.2 NR_029715 uc012hhf.1 uc012hhf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608544.1 [ECO:0000345] ##Evidence-Data-END## uc012hhf.1 uc012hhf.2 
ENSMUST00000083540.3 Mir141 ENSMUST00000083540.3 microRNA 141 (from RefSeq NR_029554.1) ENSMUST00000083540.1 ENSMUST00000083540.2 NR_029554 uc012esm.1 uc012esm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608248.1 [ECO:0000345] ##Evidence-Data-END## uc012esm.1 uc012esm.2 
ENSMUST00000083541.4 Mir27b ENSMUST00000083541.4 microRNA 27b (from RefSeq NR_029531.1) ENSMUST00000083541.1 ENSMUST00000083541.2 ENSMUST00000083541.3 NR_029531 uc011zav.1 uc011zav.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608225.1 [ECO:0000345] ##Evidence-Data-END## uc011zav.1 uc011zav.2 
ENSMUST00000083542.4 Mir30b ENSMUST00000083542.4 microRNA 30b (from RefSeq NR_029534.1) ENSMUST00000083542.1 ENSMUST00000083542.2 ENSMUST00000083542.3 NR_029534 uc011ztp.1 uc011ztp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608228.1 [ECO:0000345] ##Evidence-Data-END## uc011ztp.1 uc011ztp.2 
ENSMUST00000083543.5 Mir411 ENSMUST00000083543.5 microRNA 411 (from RefSeq NR_029916.1) ENSMUST00000083543.1 ENSMUST00000083543.2 ENSMUST00000083543.3 ENSMUST00000083543.4 NR_029916 uc011ysz.1 uc011ysz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608805.1 [ECO:0000345] ##Evidence-Data-END## uc011ysz.1 uc011ysz.2 
ENSMUST00000083545.4 Mir125a ENSMUST00000083545.4 microRNA 125a (from RefSeq NR_029539.1) ENSMUST00000083545.1 ENSMUST00000083545.2 ENSMUST00000083545.3 NR_029539 uc012alc.1 uc012alc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608233.1 [ECO:0000345] ##Evidence-Data-END## uc012alc.1 uc012alc.2 
ENSMUST00000083546.3 Mir133b ENSMUST00000083546.3 microRNA 133b (from RefSeq NR_029902.1) ENSMUST00000083546.1 ENSMUST00000083546.2 NR_029902 uc287gtn.1 uc287gtn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608738.1 [ECO:0000345] ##Evidence-Data-END## uc287gtn.1 uc287gtn.2 
ENSMUST00000083547.3 Mir346 ENSMUST00000083547.3 microRNA 346 (from RefSeq NR_029774.1) ENSMUST00000083547.1 ENSMUST00000083547.2 NR_029774 uc011ziy.1 uc011ziy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608603.1 [ECO:0000345] ##Evidence-Data-END## uc011ziy.1 uc011ziy.2 
ENSMUST00000083548.3 Mir302c ENSMUST00000083548.3 microRNA 302c (from RefSeq NR_030404.1) ENSMUST00000083548.1 ENSMUST00000083548.2 NR_030404 uc012cxi.1 uc012cxi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609616.1 [ECO:0000345] ##Evidence-Data-END## uc012cxi.1 uc012cxi.2 
ENSMUST00000083549.4 Mir181c ENSMUST00000083549.4 microRNA 181c (from RefSeq NR_029821.1) ENSMUST00000083549.1 ENSMUST00000083549.2 ENSMUST00000083549.3 NR_029821 uc012ghc.1 uc012ghc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608651.1 [ECO:0000345] ##Evidence-Data-END## uc012ghc.1 uc012ghc.2 
ENSMUST00000083550.3 Mir130a ENSMUST00000083550.3 microRNA 130a (from RefSeq NR_029544.1) ENSMUST00000083550.1 ENSMUST00000083550.2 NR_029544 uc012bym.1 uc012bym.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608238.1 [ECO:0000345] ##Evidence-Data-END## uc012bym.1 uc012bym.2 
ENSMUST00000083551.3 Mir219a-2 ENSMUST00000083551.3 microRNA 219a-2 (from RefSeq NR_029838.1) ENSMUST00000083551.1 ENSMUST00000083551.2 NR_029838 uc012btj.1 uc012btj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608668.1 [ECO:0000345] ##Evidence-Data-END## uc012btj.1 uc012btj.2 
ENSMUST00000083552.3 Mir450-1 ENSMUST00000083552.3 microRNA 450-1 (from RefSeq NR_029963.1) ENSMUST00000083552.1 ENSMUST00000083552.2 NR_029963 uc012hhk.1 uc012hhk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609025.1 [ECO:0000345] ##Evidence-Data-END## uc012hhk.1 uc012hhk.2 
ENSMUST00000083554.4 Mir196a-2 ENSMUST00000083554.4 microRNA 196a-2 (from RefSeq NR_029722.1) ENSMUST00000083554.1 ENSMUST00000083554.2 ENSMUST00000083554.3 NR_029722 uc012aae.1 uc012aae.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608551.1 [ECO:0000345] ##Evidence-Data-END## uc012aae.1 uc012aae.2 
ENSMUST00000083555.3 Mir365-2 ENSMUST00000083555.3 microRNA 365-2 (from RefSeq NR_029959.1) ENSMUST00000083555.1 ENSMUST00000083555.2 NR_029959 uc011yao.1 uc011yao.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609021.1 [ECO:0000345] ##Evidence-Data-END## uc011yao.1 uc011yao.2 
ENSMUST00000083556.3 Mir30c-1 ENSMUST00000083556.3 microRNA 30c-1 (from RefSeq NR_029716.1) ENSMUST00000083556.1 ENSMUST00000083556.2 NR_029716 uc012dkm.1 uc012dkm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608545.1 [ECO:0000345] ##Evidence-Data-END## uc012dkm.1 uc012dkm.2 
ENSMUST00000083557.3 Mir7b ENSMUST00000083557.3 microRNA 7b (from RefSeq NR_029827.1) ENSMUST00000083557.1 ENSMUST00000083557.2 NR_029827 uc012avs.1 uc012avs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608657.1, SRR1660815.380357.1 [ECO:0000345] ##Evidence-Data-END## uc012avs.1 uc012avs.2 
ENSMUST00000083558.3 Mir34b ENSMUST00000083558.3 microRNA 34b (from RefSeq NR_029655.1) ENSMUST00000083558.1 ENSMUST00000083558.2 NR_029655 uc012gte.1 uc012gte.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608446.1 [ECO:0000345] ##Evidence-Data-END## uc012gte.1 uc012gte.2 
ENSMUST00000083559.3 Mir34a ENSMUST00000083559.3 microRNA 34a (from RefSeq NR_029751.1) ENSMUST00000083559.1 ENSMUST00000083559.2 NR_029751 uc012dpu.1 uc012dpu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608580.1 [ECO:0000345] ##Evidence-Data-END## uc012dpu.1 uc012dpu.2 
ENSMUST00000083560.3 Mir28a ENSMUST00000083560.3 microRNA 28a (from RefSeq NR_029788.1) ENSMUST00000083560.1 ENSMUST00000083560.2 NR_029788 uc057kve.1 uc057kve.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc057kve.1 uc057kve.2 
ENSMUST00000083561.3 Mir150 ENSMUST00000083561.3 microRNA 150 (from RefSeq NR_029560.1) ENSMUST00000083561.1 ENSMUST00000083561.2 NR_029560 uc012fkb.1 uc012fkb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608254.1 [ECO:0000345] ##Evidence-Data-END## uc012fkb.1 uc012fkb.2 
ENSMUST00000083563.3 Mir410 ENSMUST00000083563.3 microRNA 410 (from RefSeq NR_029914.1) ENSMUST00000083563.1 ENSMUST00000083563.2 NR_029914 uc011yuk.1 uc011yuk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608803.1 [ECO:0000345] ##Evidence-Data-END## uc011yuk.1 uc011yuk.2 
ENSMUST00000083564.6 Mir379 ENSMUST00000083564.6 microRNA 379 (from RefSeq NR_029880.1) ENSMUST00000083564.1 ENSMUST00000083564.2 ENSMUST00000083564.3 ENSMUST00000083564.4 ENSMUST00000083564.5 NR_029880 uc011ysy.1 uc011ysy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608714.1 [ECO:0000345] ##Evidence-Data-END## uc011ysy.1 uc011ysy.2 
ENSMUST00000083565.3 Mir384 ENSMUST00000083565.3 microRNA 384 (from RefSeq NR_029910.1) ENSMUST00000083565.1 ENSMUST00000083565.2 NR_029910 uc012hnl.1 uc012hnl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608799.1 [ECO:0000345] ##Evidence-Data-END## uc012hnl.1 uc012hnl.2 
ENSMUST00000083566.5 Mir10b ENSMUST00000083566.5 microRNA 10b (from RefSeq NR_029566.1) ENSMUST00000083566.1 ENSMUST00000083566.2 ENSMUST00000083566.3 ENSMUST00000083566.4 NR_029566 uc012bxl.1 uc012bxl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608301.1 [ECO:0000345] ##Evidence-Data-END## uc012bxl.1 uc012bxl.2 
ENSMUST00000083567.3 Mir335 ENSMUST00000083567.3 microRNA 335 (from RefSeq NR_029900.1) ENSMUST00000083567.1 ENSMUST00000083567.2 NR_029900 uc012ejm.1 uc012ejm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608735.1 [ECO:0000345] ##Evidence-Data-END## uc012ejm.1 uc012ejm.2 
ENSMUST00000083568.3 Mir202 ENSMUST00000083568.3 microRNA 202 (from RefSeq NR_029589.1) ENSMUST00000083568.1 ENSMUST00000083568.2 NR_029589 uc012fvy.1 uc012fvy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608324.1 [ECO:0000345] ##Evidence-Data-END## uc012fvy.1 uc012fvy.2 
ENSMUST00000083569.3 Mir351 ENSMUST00000083569.3 microRNA 351 (from RefSeq NR_029776.1) ENSMUST00000083569.1 ENSMUST00000083569.2 NR_029776 uc012hhn.1 uc012hhn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608605.1 [ECO:0000345] ##Evidence-Data-END## uc012hhn.1 uc012hhn.2 
ENSMUST00000083571.3 Mir148a ENSMUST00000083571.3 microRNA 148a (from RefSeq NR_029719.1) ENSMUST00000083571.1 ENSMUST00000083571.2 NR_029719 uc012elv.1 uc012elv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608548.1 [ECO:0000345] ##Evidence-Data-END## uc012elv.1 uc012elv.2 
ENSMUST00000083573.5 Mir204 ENSMUST00000083573.5 microRNA 204 (from RefSeq NR_029591.1) ENSMUST00000083573.1 ENSMUST00000083573.2 ENSMUST00000083573.3 ENSMUST00000083573.4 NR_029591 uc012bjl.1 uc012bjl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608326.1 [ECO:0000345] ##Evidence-Data-END## uc012bjl.1 uc012bjl.2 
ENSMUST00000083574.3 Mir17 ENSMUST00000083574.3 microRNA 17 (from RefSeq NR_029785.1) ENSMUST00000083574.1 ENSMUST00000083574.2 NR_029785 uc011zpt.1 uc011zpt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608615.1 [ECO:0000345] ##Evidence-Data-END## uc011zpt.1 uc011zpt.2 
ENSMUST00000083575.5 Mir421 ENSMUST00000083575.5 microRNA 421 (from RefSeq NR_030558.1) ENSMUST00000083575.1 ENSMUST00000083575.2 ENSMUST00000083575.3 ENSMUST00000083575.4 NR_030558 uc057asl.1 uc057asl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc057asl.1 uc057asl.2 
ENSMUST00000083576.3 Mir361 ENSMUST00000083576.3 microRNA 361 (from RefSeq NR_029849.1) ENSMUST00000083576.1 ENSMUST00000083576.2 NR_029849 uc057asq.1 uc057asq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc057asq.1 uc057asq.2 
ENSMUST00000083577.3 Mir129-2 ENSMUST00000083577.3 microRNA 129-2 (from RefSeq NR_029752.1) ENSMUST00000083577.1 ENSMUST00000083577.2 NR_029752 uc012bzz.1 uc012bzz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608581.1 [ECO:0000345] ##Evidence-Data-END## uc012bzz.1 uc012bzz.2 
ENSMUST00000083578.5 Mir138-2 ENSMUST00000083578.5 microRNA 138-2 (from RefSeq NR_029552.1) ENSMUST00000083578.1 ENSMUST00000083578.2 ENSMUST00000083578.3 ENSMUST00000083578.4 NR_029552 uc012gin.1 uc012gin.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608246.1 [ECO:0000345] ##Evidence-Data-END## uc012gin.1 uc012gin.2 
ENSMUST00000083579.3 Mir26a-1 ENSMUST00000083579.3 microRNA 26a-1 (from RefSeq NR_029742.1) ENSMUST00000083579.1 ENSMUST00000083579.2 NR_029742 uc012hcg.1 uc012hcg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608571.1 [ECO:0000345] ##Evidence-Data-END## uc012hcg.1 uc012hcg.2 
ENSMUST00000083580.3 Mir106b ENSMUST00000083580.3 microRNA 106b (from RefSeq NR_029658.1) ENSMUST00000083580.1 ENSMUST00000083580.2 NR_029658 uc012efi.1 uc012efi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608449.1 [ECO:0000345] ##Evidence-Data-END## uc012efi.1 uc012efi.2 
ENSMUST00000083581.3 Mir152 ENSMUST00000083581.3 microRNA 152 (from RefSeq NR_029562.1) ENSMUST00000083581.1 ENSMUST00000083581.2 NR_029562 uc011ydo.1 uc011ydo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608256.1 [ECO:0000345] ##Evidence-Data-END## uc011ydo.1 uc011ydo.2 
ENSMUST00000083582.3 Mir214 ENSMUST00000083582.3 microRNA 214 (from RefSeq NR_029796.1) ENSMUST00000083582.1 ENSMUST00000083582.2 NR_029796 uc287nfb.1 uc287nfb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608626.1 [ECO:0000345] ##Evidence-Data-END## uc287nfb.1 uc287nfb.2 
ENSMUST00000083584.4 Mir423 ENSMUST00000083584.4 microRNA 423 (from RefSeq NR_030756.1) ENSMUST00000083584.1 ENSMUST00000083584.2 ENSMUST00000083584.3 NR_030756 uc011xzs.1 uc011xzs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609680.1 [ECO:0000345] ##Evidence-Data-END## uc011xzs.1 uc011xzs.2 
ENSMUST00000083585.3 Mir10a ENSMUST00000083585.3 microRNA 10a (from RefSeq NR_029784.1) ENSMUST00000083585.1 ENSMUST00000083585.2 NR_029784 uc011ydg.1 uc011ydg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608614.1 [ECO:0000345] ##Evidence-Data-END## uc011ydg.1 uc011ydg.2 
ENSMUST00000083586.4 Mir128-1 ENSMUST00000083586.4 microRNA 128-1 (from RefSeq NR_029543.1) ENSMUST00000083586.1 ENSMUST00000083586.2 ENSMUST00000083586.3 NR_029543 uc011wrc.1 uc011wrc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608237.1 [ECO:0000345] ##Evidence-Data-END## uc011wrc.1 uc011wrc.2 
ENSMUST00000083587.3 Mir296 ENSMUST00000083587.3 microRNA 296 (from RefSeq NR_029646.1) ENSMUST00000083587.1 ENSMUST00000083587.2 NR_029646 uc012cku.1 uc012cku.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608437.1 [ECO:0000345] ##Evidence-Data-END## uc012cku.1 uc012cku.2 
ENSMUST00000083589.3 Mir192 ENSMUST00000083589.3 microRNA 192 (from RefSeq NR_029720.1) ENSMUST00000083589.1 ENSMUST00000083589.2 NR_029720 uc012bhk.1 uc012bhk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608549.1 [ECO:0000345] ##Evidence-Data-END## uc012bhk.1 uc012bhk.2 
ENSMUST00000083590.3 Mir135a-2 ENSMUST00000083590.3 microRNA 135a-2 (from RefSeq NR_029812.1) ENSMUST00000083590.1 ENSMUST00000083590.2 NR_029812 uc007gty.1 uc007gty.2 uc007gty.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608642.1 [ECO:0000345] ##Evidence-Data-END## uc007gty.1 uc007gty.2 uc007gty.3 
ENSMUST00000083592.6 Mir337 ENSMUST00000083592.6 microRNA 337 (from RefSeq NR_029765.1) ENSMUST00000083592.1 ENSMUST00000083592.2 ENSMUST00000083592.3 ENSMUST00000083592.4 ENSMUST00000083592.5 NR_029765 uc011ysf.1 uc011ysf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608594.1 [ECO:0000345] ##Evidence-Data-END## uc011ysf.1 uc011ysf.2 
ENSMUST00000083593.3 Mir93 ENSMUST00000083593.3 microRNA 93 (from RefSeq NR_029749.1) ENSMUST00000083593.1 ENSMUST00000083593.2 NR_029749 uc012efh.1 uc012efh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608578.1 [ECO:0000345] ##Evidence-Data-END## uc012efh.1 uc012efh.2 
ENSMUST00000083594.3 Mir320 ENSMUST00000083594.3 microRNA 320 (from RefSeq NR_029802.1) ENSMUST00000083594.1 ENSMUST00000083594.2 NR_029802 uc011zoa.1 uc011zoa.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608632.1 [ECO:0000345] ##Evidence-Data-END## uc011zoa.1 uc011zoa.2 
ENSMUST00000083595.3 Mir22 ENSMUST00000083595.3 microRNA 22 (from RefSeq NR_029739.1) ENSMUST00000083595.1 ENSMUST00000083595.2 NR_029739 uc011xzk.1 uc011xzk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608568.1 [ECO:0000345] ##Evidence-Data-END## uc011xzk.1 uc011xzk.2 
ENSMUST00000083596.3 Mir99a ENSMUST00000083596.3 microRNA 99a (from RefSeq NR_029535.1) ENSMUST00000083596.1 ENSMUST00000083596.2 NR_029535 uc012ahd.1 uc012ahd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608229.1 [ECO:0000345] ##Evidence-Data-END## uc012ahd.1 uc012ahd.2 
ENSMUST00000083598.3 Mir187 ENSMUST00000083598.3 microRNA 187 (from RefSeq NR_029573.1) ENSMUST00000083598.1 ENSMUST00000083598.2 NR_029573 uc008egs.1 uc008egs.2 uc008egs.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608309.1 [ECO:0000345] ##Evidence-Data-END## uc008egs.1 uc008egs.2 uc008egs.3 
ENSMUST00000083599.3 Mir205 ENSMUST00000083599.3 microRNA 205 (from RefSeq NR_029592.1) ENSMUST00000083599.1 ENSMUST00000083599.2 NR_029592 uc011wzc.1 uc011wzc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608327.1 [ECO:0000345] ##Evidence-Data-END## uc011wzc.1 uc011wzc.2 
ENSMUST00000083600.3 Mir324 ENSMUST00000083600.3 microRNA 324 (from RefSeq NR_029758.1) ENSMUST00000083600.1 ENSMUST00000083600.2 NR_029758 uc011xxn.1 uc011xxn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608587.1 [ECO:0000345] ##Evidence-Data-END## uc011xxn.1 uc011xxn.2 
ENSMUST00000083602.4 Mir98 ENSMUST00000083602.4 microRNA 98 (from RefSeq NR_029753.1) ENSMUST00000083602.1 ENSMUST00000083602.2 ENSMUST00000083602.3 NR_029753 uc012hqv.1 uc012hqv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608582.1 [ECO:0000345] ##Evidence-Data-END## uc012hqv.1 uc012hqv.2 
ENSMUST00000083603.4 Mir132 ENSMUST00000083603.4 microRNA 132 (from RefSeq NR_029546.1) ENSMUST00000083603.1 ENSMUST00000083603.2 ENSMUST00000083603.3 NR_029546 uc011xzh.1 uc011xzh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608240.1 [ECO:0000345] ##Evidence-Data-END## uc011xzh.1 uc011xzh.2 
ENSMUST00000083604.3 Mir153 ENSMUST00000083604.3 microRNA 153 (from RefSeq NR_029563.1) ENSMUST00000083604.1 ENSMUST00000083604.2 NR_029563 uc011yvr.1 uc011yvr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608257.1, SRR1660811.196854.1 [ECO:0000345] ##Evidence-Data-END## uc011yvr.1 uc011yvr.2 
ENSMUST00000083605.3 Mir216a ENSMUST00000083605.3 microRNA 216a (from RefSeq NR_029797.1) ENSMUST00000083605.1 ENSMUST00000083605.2 NR_029797 uc011xsm.1 uc011xsm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608627.1 [ECO:0000345] ##Evidence-Data-END## uc011xsm.1 uc011xsm.2 
ENSMUST00000083606.3 Mir126a ENSMUST00000083606.3 microRNA 126a (from RefSeq NR_029541.1) ENSMUST00000083606.1 ENSMUST00000083606.2 NR_029541 uc012bsm.1 uc012bsm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608235.1 [ECO:0000345] ##Evidence-Data-END## uc012bsm.1 uc012bsm.2 
ENSMUST00000083607.3 Mir24-2 ENSMUST00000083607.3 microRNA 24-2 (from RefSeq NR_029741.1) ENSMUST00000083607.1 ENSMUST00000083607.2 NR_029741 uc012ghf.1 uc012ghf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608570.1 [ECO:0000345] ##Evidence-Data-END## uc012ghf.1 uc012ghf.2 
ENSMUST00000083608.3 Mir224 ENSMUST00000083608.3 microRNA 224 (from RefSeq NR_029808.1) ENSMUST00000083608.1 ENSMUST00000083608.2 NR_029808 uc057art.1 uc057art.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608638.1 [ECO:0000345] ##Evidence-Data-END## uc057art.1 uc057art.2 
ENSMUST00000083609.3 Mir330 ENSMUST00000083609.3 microRNA 330 (from RefSeq NR_029763.1) ENSMUST00000083609.1 ENSMUST00000083609.2 NR_029763 uc012faz.1 uc012faz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608592.1 [ECO:0000345] ##Evidence-Data-END## uc012faz.1 uc012faz.2 
ENSMUST00000083610.2 Mir32 ENSMUST00000083610.2 microRNA 32 (from RefSeq NR_029789.1) ENSMUST00000083610.1 NR_029789 uc012dem.1 uc012dem.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608619.1 [ECO:0000345] ##Evidence-Data-END## uc012dem.1 uc012dem.2 
ENSMUST00000083612.3 Mir196a-1 ENSMUST00000083612.3 microRNA 196a-1 (from RefSeq NR_029721.1) ENSMUST00000083612.1 ENSMUST00000083612.2 NR_029721 uc011ydf.1 uc011ydf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608550.1 [ECO:0000345] ##Evidence-Data-END## uc011ydf.1 uc011ydf.2 
ENSMUST00000083613.3 Mir199a-1 ENSMUST00000083613.3 microRNA 199a-1 (from RefSeq NR_029585.1) ENSMUST00000083613.1 ENSMUST00000083613.2 NR_029585 uc009olo.1 uc009olo.2 uc009olo.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608320.1 [ECO:0000345] ##Evidence-Data-END## uc009olo.1 uc009olo.2 uc009olo.3 
ENSMUST00000083614.3 Mir29c ENSMUST00000083614.3 microRNA 29c (from RefSeq NR_029745.1) ENSMUST00000083614.1 ENSMUST00000083614.2 NR_029745 uc011wzg.1 uc011wzg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608574.1 [ECO:0000345] ##Evidence-Data-END## uc011wzg.1 uc011wzg.2 
ENSMUST00000083615.5 Mir200b ENSMUST00000083615.5 microRNA 200b (from RefSeq NR_029587.1) ENSMUST00000083615.1 ENSMUST00000083615.2 ENSMUST00000083615.3 ENSMUST00000083615.4 NR_029587 uc012drf.1 uc012drf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608322.1 [ECO:0000345] ##Evidence-Data-END## uc012drf.1 uc012drf.2 
ENSMUST00000083617.3 Mir210 ENSMUST00000083617.3 microRNA 210 (from RefSeq NR_029793.1) ENSMUST00000083617.1 ENSMUST00000083617.2 NR_029793 uc012fws.1 uc012fws.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608623.1 [ECO:0000345] ##Evidence-Data-END## uc012fws.1 uc012fws.2 
ENSMUST00000083618.3 Mir302a ENSMUST00000083618.3 microRNA 302a (from RefSeq NR_029653.1) ENSMUST00000083618.1 ENSMUST00000083618.2 NR_029653 uc012cxj.1 uc012cxj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608444.1 [ECO:0000345] ##Evidence-Data-END## uc012cxj.1 uc012cxj.2 
ENSMUST00000083619.3 Mir103-1 ENSMUST00000083619.3 microRNA 103-1 (from RefSeq NR_029754.1) ENSMUST00000083619.1 ENSMUST00000083619.2 NR_029754 uc011xtb.1 uc011xtb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608583.1 [ECO:0000345] ##Evidence-Data-END## uc011xtb.1 uc011xtb.2 
ENSMUST00000083621.3 Mir219a-1 ENSMUST00000083621.3 microRNA 219a-1 (from RefSeq NR_029800.1) ENSMUST00000083621.1 ENSMUST00000083621.2 NR_029800 uc012apr.1 uc012apr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608630.1 [ECO:0000345] ##Evidence-Data-END## uc012apr.1 uc012apr.2 
ENSMUST00000083622.3 Mir101b ENSMUST00000083622.3 microRNA 101b (from RefSeq NR_029778.1) ENSMUST00000083622.1 ENSMUST00000083622.2 NR_029778 uc012bki.1 uc012bki.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608607.1 [ECO:0000345] ##Evidence-Data-END## uc012bki.1 uc012bki.2 
ENSMUST00000083623.5 Mirlet7c-1 ENSMUST00000083623.5 microRNA let7c-1 (from RefSeq NR_029728.1) ENSMUST00000083623.1 ENSMUST00000083623.2 ENSMUST00000083623.3 ENSMUST00000083623.4 NR_029728 uc012ahe.1 uc012ahe.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608557.1 [ECO:0000345] ##Evidence-Data-END## uc012ahe.1 uc012ahe.2 
ENSMUST00000083625.3 Mir206 ENSMUST00000083625.3 microRNA 206 (from RefSeq NR_029593.1) ENSMUST00000083625.1 ENSMUST00000083625.2 NR_029593 uc287gtl.1 uc287gtl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608328.1 [ECO:0000345] ##Evidence-Data-END## uc287gtl.1 uc287gtl.2 
ENSMUST00000083626.3 Mir148b ENSMUST00000083626.3 microRNA 148b (from RefSeq NR_029766.1) ENSMUST00000083626.1 ENSMUST00000083626.2 NR_029766 uc012aaj.1 uc012aaj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608595.1 [ECO:0000345] ##Evidence-Data-END## uc012aaj.1 uc012aaj.2 
ENSMUST00000083627.4 Mir369 ENSMUST00000083627.4 microRNA 369 (from RefSeq NR_030272.1) ENSMUST00000083627.1 ENSMUST00000083627.2 ENSMUST00000083627.3 NR_030272 uc011yuj.1 uc011yuj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609542.1 [ECO:0000345] ##Evidence-Data-END## uc011yuj.1 uc011yuj.2 
ENSMUST00000083628.3 Mir215 ENSMUST00000083628.3 microRNA 215 (from RefSeq NR_029908.1) ENSMUST00000083628.1 ENSMUST00000083628.2 NR_029908 uc011wyc.1 uc011wyc.2 uc011wyc.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608743.1 [ECO:0000345] ##Evidence-Data-END## uc011wyc.1 uc011wyc.2 uc011wyc.3 
ENSMUST00000083629.3 Mir103-2 ENSMUST00000083629.3 microRNA 103-2 (from RefSeq NR_029755.1) ENSMUST00000083629.1 ENSMUST00000083629.2 NR_029755 uc012cem.1 uc012cem.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608584.1 [ECO:0000345] ##Evidence-Data-END## uc012cem.1 uc012cem.2 
ENSMUST00000083630.3 Mirlet7b ENSMUST00000083630.3 microRNA let7b (from RefSeq NR_029727.1) ENSMUST00000083630.1 ENSMUST00000083630.2 NR_029727 uc011zxn.1 uc011zxn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608556.1 [ECO:0000345] ##Evidence-Data-END## uc011zxn.1 uc011zxn.2 
ENSMUST00000083631.3 Mir181a-1 ENSMUST00000083631.3 microRNA 181a-1 (from RefSeq NR_029795.1) ENSMUST00000083631.1 ENSMUST00000083631.2 NR_029795 uc007cve.1 uc007cve.2 uc007cve.3 uc007cve.4 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608625.1 [ECO:0000345] ##Evidence-Data-END## uc007cve.1 uc007cve.2 uc007cve.3 uc007cve.4 
ENSMUST00000083632.5 Mir381 ENSMUST00000083632.5 microRNA 381 (from RefSeq NR_029882.1) ENSMUST00000083632.1 ENSMUST00000083632.2 ENSMUST00000083632.3 ENSMUST00000083632.4 NR_029882 uc011yts.1 uc011yts.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608716.1 [ECO:0000345] ##Evidence-Data-END## uc011yts.1 uc011yts.2 
ENSMUST00000083633.3 Mir30c-2 ENSMUST00000083633.3 microRNA 30c-2 (from RefSeq NR_029717.1) ENSMUST00000083633.1 ENSMUST00000083633.2 NR_029717 uc007ama.1 uc007ama.2 uc007ama.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608546.1 [ECO:0000345] ##Evidence-Data-END## uc007ama.1 uc007ama.2 uc007ama.3 
ENSMUST00000083634.3 Mir344 ENSMUST00000083634.3 microRNA 344 (from RefSeq NR_029772.1) ENSMUST00000083634.1 ENSMUST00000083634.2 NR_029772 uc012fmh.1 uc012fmh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608601.1 [ECO:0000345] ##Evidence-Data-END## uc012fmh.1 uc012fmh.2 
ENSMUST00000083635.4 Mir137 ENSMUST00000083635.4 microRNA 137 (from RefSeq NR_029551.1) ENSMUST00000083635.1 ENSMUST00000083635.2 ENSMUST00000083635.3 NR_029551 uc012cwx.1 uc012cwx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608245.1 [ECO:0000345] ##Evidence-Data-END## uc012cwx.1 uc012cwx.2 
ENSMUST00000083636.3 Mir412 ENSMUST00000083636.3 microRNA 412 (from RefSeq NR_029917.1) ENSMUST00000083636.1 ENSMUST00000083636.2 NR_029917 uc011yui.1 uc011yui.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM608806.1 [ECO:0000345] ##Evidence-Data-END## uc011yui.1 uc011yui.2 
ENSMUST00000083637.3 Mir326 ENSMUST00000083637.3 microRNA 326 (from RefSeq NR_029760.1) ENSMUST00000083637.1 ENSMUST00000083637.2 NR_029760 uc012fpw.1 uc012fpw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608589.1 [ECO:0000345] ##Evidence-Data-END## uc012fpw.1 uc012fpw.2 
ENSMUST00000083638.3 Mir130b ENSMUST00000083638.3 microRNA 130b (from RefSeq NR_029659.1) ENSMUST00000083638.1 ENSMUST00000083638.2 NR_029659 uc012abo.1 uc012abo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608450.1 [ECO:0000345] ##Evidence-Data-END## uc012abo.1 uc012abo.2 
ENSMUST00000083639.3 Mir350 ENSMUST00000083639.3 microRNA 350 (from RefSeq NR_029775.1) ENSMUST00000083639.1 ENSMUST00000083639.2 NR_029775 uc011wxg.1 uc011wxg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608604.1 [ECO:0000345] ##Evidence-Data-END## uc011wxg.1 uc011wxg.2 
ENSMUST00000083640.3 Mir203 ENSMUST00000083640.3 microRNA 203 (from RefSeq NR_029590.1) ENSMUST00000083640.1 ENSMUST00000083640.2 NR_029590 uc007pel.1 uc007pel.2 uc007pel.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608325.1 [ECO:0000345] ##Evidence-Data-END## uc007pel.1 uc007pel.2 uc007pel.3 
ENSMUST00000083641.3 Mir449a ENSMUST00000083641.3 microRNA 449a (from RefSeq NR_029961.1) ENSMUST00000083641.1 ENSMUST00000083641.2 NR_029961 uc011zet.1 uc011zet.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609023.1 [ECO:0000345] ##Evidence-Data-END## uc011zet.1 uc011zet.2 
ENSMUST00000083643.3 Mir329 ENSMUST00000083643.3 microRNA 329 (from RefSeq NR_029762.1) ENSMUST00000083643.1 ENSMUST00000083643.2 NR_029762 uc011ytf.1 uc011ytf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608591.1 [ECO:0000345] ##Evidence-Data-END## uc011ytf.1 uc011ytf.2 
ENSMUST00000083644.3 Mir181b-2 ENSMUST00000083644.3 microRNA 181b-2 (from RefSeq NR_029904.1) ENSMUST00000083644.1 ENSMUST00000083644.2 NR_029904 uc012buw.1 uc012buw.2 uc012buw.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608740.1, SRR1660825.56677.1 [ECO:0000345] ##Evidence-Data-END## uc012buw.1 uc012buw.2 uc012buw.3 
ENSMUST00000083645.3 Mir425 ENSMUST00000083645.3 microRNA 425 (from RefSeq NR_029947.1) ENSMUST00000083645.1 ENSMUST00000083645.2 NR_029947 uc292lhe.1 uc292lhe.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608935.1 [ECO:0000345] ##Evidence-Data-END## uc292lhe.1 uc292lhe.2 
ENSMUST00000083646.4 Mir15b ENSMUST00000083646.4 microRNA 15b (from RefSeq NR_029529.1) ENSMUST00000083646.1 ENSMUST00000083646.2 ENSMUST00000083646.3 NR_029529 uc012cqk.1 uc012cqk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608223.1 [ECO:0000345] ##Evidence-Data-END## uc012cqk.1 uc012cqk.2 
ENSMUST00000083647.3 Mir194-1 ENSMUST00000083647.3 microRNA 194-1 (from RefSeq NR_029580.1) ENSMUST00000083647.1 ENSMUST00000083647.2 NR_029580 uc011wyb.1 uc011wyb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608316.1 [ECO:0000345] ##Evidence-Data-END## uc011wyb.1 uc011wyb.2 
ENSMUST00000083648.3 Mir194-2 ENSMUST00000083648.3 microRNA 194-2 (from RefSeq NR_029830.1) ENSMUST00000083648.1 ENSMUST00000083648.2 NR_029830 uc008ghx.1 uc008ghx.2 uc008ghx.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608660.1 [ECO:0000345] ##Evidence-Data-END## uc008ghx.1 uc008ghx.2 uc008ghx.3 
ENSMUST00000083649.3 Mir218-2 ENSMUST00000083649.3 microRNA 218-2 (from RefSeq NR_029799.1) ENSMUST00000083649.1 ENSMUST00000083649.2 NR_029799 uc011xta.1 uc011xta.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608629.1 [ECO:0000345] ##Evidence-Data-END## uc011xta.1 uc011xta.2 
ENSMUST00000083651.3 Mir211 ENSMUST00000083651.3 microRNA 211 (from RefSeq NR_029805.1) ENSMUST00000083651.1 ENSMUST00000083651.2 NR_029805 uc012fmo.1 uc012fmo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608635.1 [ECO:0000345] ##Evidence-Data-END## uc012fmo.1 uc012fmo.2 
ENSMUST00000083652.3 Mir96 ENSMUST00000083652.3 microRNA 96 (from RefSeq NR_029750.1) ENSMUST00000083652.1 ENSMUST00000083652.2 NR_029750 uc012eji.1 uc012eji.2 uc012eji.3 uc012eji.4 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608579.1 [ECO:0000345] ##Evidence-Data-END## uc012eji.1 uc012eji.2 uc012eji.3 uc012eji.4 
ENSMUST00000083653.3 Mir34c ENSMUST00000083653.3 microRNA 34c (from RefSeq NR_029654.1) ENSMUST00000083653.1 ENSMUST00000083653.2 NR_029654 uc012gtd.1 uc012gtd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608445.1 [ECO:0000345] ##Evidence-Data-END## uc012gtd.1 uc012gtd.2 
ENSMUST00000083655.3 Mir301 ENSMUST00000083655.3 microRNA 301 (from RefSeq NR_029652.1) ENSMUST00000083655.1 ENSMUST00000083655.2 NR_029652 uc011ybv.1 uc011ybv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608443.1 [ECO:0000345] ##Evidence-Data-END## uc011ybv.1 uc011ybv.2 
ENSMUST00000083656.3 Mir212 ENSMUST00000083656.3 microRNA 212 (from RefSeq NR_029794.1) ENSMUST00000083656.1 ENSMUST00000083656.2 NR_029794 uc011xzg.1 uc011xzg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608624.1 [ECO:0000345] ##Evidence-Data-END## uc011xzg.1 uc011xzg.2 
ENSMUST00000083657.3 Gm22753 ENSMUST00000083657.3 Gm22753 (from geneSymbol) ENSMUST00000083657.1 ENSMUST00000083657.2 uc287wzf.1 uc287wzf.2 uc287wzf.1 uc287wzf.2 
ENSMUST00000083658.4 Mir145a ENSMUST00000083658.4 microRNA 145a (from RefSeq NR_029557.1) ENSMUST00000083658.1 ENSMUST00000083658.2 ENSMUST00000083658.3 NR_029557 uc008fci.1 uc008fci.2 uc008fci.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608251.1 [ECO:0000345] ##Evidence-Data-END## uc008fci.1 uc008fci.2 uc008fci.3 
ENSMUST00000083659.3 Mir339 ENSMUST00000083659.3 microRNA 339 (from RefSeq NR_029768.1) ENSMUST00000083659.1 ENSMUST00000083659.2 NR_029768 uc012efw.1 uc012efw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608597.1 [ECO:0000345] ##Evidence-Data-END## uc012efw.1 uc012efw.2 
ENSMUST00000083660.3 Mir107 ENSMUST00000083660.3 microRNA 107 (from RefSeq NR_029783.1) ENSMUST00000083660.1 ENSMUST00000083660.2 NR_029783 uc012bkw.1 uc012bkw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608613.1 [ECO:0000345] ##Evidence-Data-END## uc012bkw.1 uc012bkw.2 
ENSMUST00000083662.3 Mir184 ENSMUST00000083662.3 microRNA 184 (from RefSeq NR_029570.1) ENSMUST00000083662.1 ENSMUST00000083662.2 NR_029570 uc012gye.1 uc012gye.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608306.1 [ECO:0000345] ##Evidence-Data-END## uc012gye.1 uc012gye.2 
ENSMUST00000083663.3 Mir124a-1 ENSMUST00000083663.3 microRNA 124a-1 (from RefSeq NR_029813.1) ENSMUST00000083663.1 ENSMUST00000083663.2 NR_029813 uc011znk.1 uc011znk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608643.1 [ECO:0000345] ##Evidence-Data-END## uc011znk.1 uc011znk.2 
ENSMUST00000083665.4 Mir23b ENSMUST00000083665.4 microRNA 23b (from RefSeq NR_029530.1) ENSMUST00000083665.1 ENSMUST00000083665.2 ENSMUST00000083665.3 NR_029530 uc007qxn.1 uc007qxn.2 uc007qxn.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608224.1 [ECO:0000345] ##Evidence-Data-END## uc007qxn.1 uc007qxn.2 uc007qxn.3 
ENSMUST00000083666.3 Mir338 ENSMUST00000083666.3 microRNA 338 (from RefSeq NR_029767.1) ENSMUST00000083666.1 ENSMUST00000083666.2 NR_029767 uc011yiu.1 uc011yiu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608596.1 [ECO:0000345] ##Evidence-Data-END## uc011yiu.1 uc011yiu.2 
ENSMUST00000083667.3 Mir146 ENSMUST00000083667.3 microRNA 146 (from RefSeq NR_029558.1) ENSMUST00000083667.1 ENSMUST00000083667.2 NR_029558 uc011xtg.1 uc011xtg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608252.1 [ECO:0000345] ##Evidence-Data-END## uc011xtg.1 uc011xtg.2 
ENSMUST00000083668.3 Mirlet7f-2 ENSMUST00000083668.3 microRNA let7f-2 (from RefSeq NR_029732.1) ENSMUST00000083668.1 ENSMUST00000083668.2 NR_029732 uc012hqu.1 uc012hqu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608561.1 [ECO:0000345] ##Evidence-Data-END## uc012hqu.1 uc012hqu.2 
ENSMUST00000083669.3 Mir218-1 ENSMUST00000083669.3 microRNA 218-1 (from RefSeq NR_029798.1) ENSMUST00000083669.1 ENSMUST00000083669.2 NR_029798 uc012dwd.1 uc012dwd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608628.1 [ECO:0000345] ##Evidence-Data-END## uc012dwd.1 uc012dwd.2 
ENSMUST00000083670.4 Mir29b-1 ENSMUST00000083670.4 microRNA 29b-1 (from RefSeq NR_029532.1) ENSMUST00000083670.1 ENSMUST00000083670.2 ENSMUST00000083670.3 NR_029532 uc012ejr.1 uc012ejr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608226.1 [ECO:0000345] ##Evidence-Data-END## uc012ejr.1 uc012ejr.2 
ENSMUST00000083672.3 Mir16-2 ENSMUST00000083672.3 microRNA 16-2 (from RefSeq NR_029735.1) ENSMUST00000083672.1 ENSMUST00000083672.2 NR_029735 uc012cql.1 uc012cql.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608564.1 [ECO:0000345] ##Evidence-Data-END## uc012cql.1 uc012cql.2 
ENSMUST00000083673.3 Mir331 ENSMUST00000083673.3 microRNA 331 (from RefSeq NR_029764.1) ENSMUST00000083673.1 ENSMUST00000083673.2 NR_029764 uc011xly.1 uc011xly.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608593.1 [ECO:0000345] ##Evidence-Data-END## uc011xly.1 uc011xly.2 
ENSMUST00000083674.3 Mirlet7c-2 ENSMUST00000083674.3 microRNA let7c-2 (from RefSeq NR_029729.1) ENSMUST00000083674.1 ENSMUST00000083674.2 NR_029729 uc011zxm.1 uc011zxm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608558.1 [ECO:0000345] ##Evidence-Data-END## uc011zxm.1 uc011zxm.2 
ENSMUST00000083675.3 Mir7-2 ENSMUST00000083675.3 microRNA 7-2 (from RefSeq NR_029826.1) ENSMUST00000083675.1 ENSMUST00000083675.2 NR_029826 uc012fne.1 uc012fne.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608656.1 [ECO:0000345] ##Evidence-Data-END## uc012fne.1 uc012fne.2 
ENSMUST00000083676.3 Mir29a ENSMUST00000083676.3 microRNA 29a (from RefSeq NR_029744.1) ENSMUST00000083676.1 ENSMUST00000083676.2 NR_029744 uc012ejq.1 uc012ejq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608573.1 [ECO:0000345] ##Evidence-Data-END## uc012ejq.1 uc012ejq.2 
ENSMUST00000083677.3 Mir23a ENSMUST00000083677.3 microRNA 23a (from RefSeq NR_029740.1) ENSMUST00000083677.1 ENSMUST00000083677.2 NR_029740 uc012ghd.1 uc012ghd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608569.1 [ECO:0000345] ##Evidence-Data-END## uc012ghd.1 uc012ghd.2 
ENSMUST00000083678.3 Mir151 ENSMUST00000083678.3 microRNA 151 (from RefSeq NR_029561.1) ENSMUST00000083678.1 ENSMUST00000083678.2 NR_029561 uc056yzc.1 uc056yzc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc056yzc.1 uc056yzc.2 
ENSMUST00000083679.3 Mir92-2 ENSMUST00000083679.3 microRNA 92-2 (from RefSeq NR_029748.1) ENSMUST00000083679.1 ENSMUST00000083679.2 NR_029748 uc012hhe.1 uc012hhe.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608577.1 [ECO:0000345] ##Evidence-Data-END## uc012hhe.1 uc012hhe.2 
ENSMUST00000083682.5 Mir375 ENSMUST00000083682.5 microRNA 375 (from RefSeq NR_029876.1) ENSMUST00000083682.1 ENSMUST00000083682.2 ENSMUST00000083682.3 ENSMUST00000083682.4 NR_029876 uc011wne.1 uc011wne.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608710.1 [ECO:0000345] ##Evidence-Data-END## uc011wne.1 uc011wne.2 
ENSMUST00000083683.3 Mir323 ENSMUST00000083683.3 microRNA 323 (from RefSeq NR_029757.1) ENSMUST00000083683.1 ENSMUST00000083683.2 NR_029757 uc011ytd.1 uc011ytd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608586.1 [ECO:0000345] ##Evidence-Data-END## uc011ytd.1 uc011ytd.2 
ENSMUST00000083685.4 Mir183 ENSMUST00000083685.4 microRNA 183 (from RefSeq NR_030713.1) ENSMUST00000083685.1 ENSMUST00000083685.2 ENSMUST00000083685.3 NR_030713 uc057lph.1 uc057lph.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608305.1 [ECO:0000345] ##Evidence-Data-END## uc057lph.1 uc057lph.2 
ENSMUST00000083686.3 Gm24764 ENSMUST00000083686.3 Gm24764 (from geneSymbol) ENSMUST00000083686.1 ENSMUST00000083686.2 uc292fwm.1 uc292fwm.2 uc292fwm.1 uc292fwm.2 
ENSMUST00000083688.3 Gm24763 ENSMUST00000083688.3 Gm24763 (from geneSymbol) ENSMUST00000083688.1 ENSMUST00000083688.2 uc292nyr.1 uc292nyr.2 uc292nyr.1 uc292nyr.2 
ENSMUST00000083689.3 Gm24762 ENSMUST00000083689.3 Gm24762 (from geneSymbol) ENSMUST00000083689.1 ENSMUST00000083689.2 LF194661 uc290qmg.1 uc290qmg.2 uc290qmg.1 uc290qmg.2 
ENSMUST00000083691.3 Gm24765 ENSMUST00000083691.3 Gm24765 (from geneSymbol) ENSMUST00000083691.1 ENSMUST00000083691.2 uc287gjd.1 uc287gjd.2 uc287gjd.1 uc287gjd.2 
ENSMUST00000083695.4 Gm24826 ENSMUST00000083695.4 Gm24826 (from geneSymbol) ENSMUST00000083695.1 ENSMUST00000083695.2 ENSMUST00000083695.3 uc287hoh.1 uc287hoh.2 uc287hoh.1 uc287hoh.2 
ENSMUST00000083696.4 Gm24256 ENSMUST00000083696.4 Gm24256 (from geneSymbol) ENSMUST00000083696.1 ENSMUST00000083696.2 ENSMUST00000083696.3 uc287rah.1 uc287rah.2 uc287rah.1 uc287rah.2 
ENSMUST00000083700.3 Gm24252 ENSMUST00000083700.3 Gm24252 (from geneSymbol) ENSMUST00000083700.1 ENSMUST00000083700.2 uc289rlq.1 uc289rlq.2 uc289rlq.1 uc289rlq.2 
ENSMUST00000083701.3 Gm24253 ENSMUST00000083701.3 Gm24253 (from geneSymbol) AJ543402 ENSMUST00000083701.1 ENSMUST00000083701.2 uc287yho.1 uc287yho.2 uc287yho.1 uc287yho.2 
ENSMUST00000083702.3 Gm24254 ENSMUST00000083702.3 Gm24254 (from geneSymbol) ENSMUST00000083702.1 ENSMUST00000083702.2 uc292cas.1 uc292cas.2 uc292cas.1 uc292cas.2 
ENSMUST00000083703.3 Gm26397 ENSMUST00000083703.3 Gm26397 (from geneSymbol) ENSMUST00000083703.1 ENSMUST00000083703.2 LF197401 uc292ecv.1 uc292ecv.2 uc292ecv.1 uc292ecv.2 
ENSMUST00000083706.3 Snord1c ENSMUST00000083706.3 small nucleolar RNA, C/D box 1C (from RefSeq NR_028569.1) ENSMUST00000083706.1 ENSMUST00000083706.2 NR_028569 uc288dud.1 uc288dud.2 uc288dud.1 uc288dud.2 
ENSMUST00000083708.3 Snora69 ENSMUST00000083708.3 small nucleolar RNA, H/ACA box 69 (from RefSeq NR_002900.1) ENSMUST00000083708.1 ENSMUST00000083708.2 NR_002900 uc009syd.1 uc009syd.2 uc009syd.3 uc009syd.1 uc009syd.2 uc009syd.3 
ENSMUST00000083709.3 Gm25897 ENSMUST00000083709.3 Gm25897 (from geneSymbol) ENSMUST00000083709.1 ENSMUST00000083709.2 uc289bhz.1 uc289bhz.2 uc289bhz.1 uc289bhz.2 
ENSMUST00000083713.3 Gm25896 ENSMUST00000083713.3 Gm25896 (from geneSymbol) ENSMUST00000083713.1 ENSMUST00000083713.2 uc289ftx.1 uc289ftx.2 uc289ftx.1 uc289ftx.2 
ENSMUST00000083714.3 Gm25895 ENSMUST00000083714.3 Gm25895 (from geneSymbol) ENSMUST00000083714.1 ENSMUST00000083714.2 uc292rih.1 uc292rih.2 uc292rih.1 uc292rih.2 
ENSMUST00000083715.3 Snora74a ENSMUST00000083715.3 small nucleolar RNA, H/ACA box 74A (from RefSeq NR_002905.3) ENSMUST00000083715.1 ENSMUST00000083715.2 NR_002905 uc012bbh.1 uc012bbh.2 uc012bbh.3 uc012bbh.1 uc012bbh.2 uc012bbh.3 
ENSMUST00000083717.4 Gm25973 ENSMUST00000083717.4 Gm25973 (from geneSymbol) ENSMUST00000083717.1 ENSMUST00000083717.2 ENSMUST00000083717.3 uc289kvy.1 uc289kvy.2 uc289kvy.1 uc289kvy.2 
ENSMUST00000083719.3 Gm23105 ENSMUST00000083719.3 Gm23105 (from geneSymbol) ENSMUST00000083719.1 ENSMUST00000083719.2 uc287usv.1 uc287usv.2 uc287usv.1 uc287usv.2 
ENSMUST00000083722.4 Gm23104 ENSMUST00000083722.4 Gm23104 (from geneSymbol) ENSMUST00000083722.1 ENSMUST00000083722.2 ENSMUST00000083722.3 uc288mmv.1 uc288mmv.2 uc288mmv.1 uc288mmv.2 
ENSMUST00000083723.3 Gm25337 ENSMUST00000083723.3 Gm25337 (from geneSymbol) ENSMUST00000083723.1 ENSMUST00000083723.2 uc288cqs.1 uc288cqs.2 uc288cqs.1 uc288cqs.2 
ENSMUST00000083724.3 Gm23102 ENSMUST00000083724.3 Gm23102 (from geneSymbol) ENSMUST00000083724.1 ENSMUST00000083724.2 uc289nog.1 uc289nog.2 uc289nog.1 uc289nog.2 
ENSMUST00000083729.3 Gm22579 ENSMUST00000083729.3 Gm22579 (from geneSymbol) AK135416 ENSMUST00000083729.1 ENSMUST00000083729.2 uc292epy.1 uc292epy.2 uc292epy.1 uc292epy.2 
ENSMUST00000083730.3 Gm22578 ENSMUST00000083730.3 Gm22578 (from geneSymbol) ENSMUST00000083730.1 ENSMUST00000083730.2 uc291klj.1 uc291klj.2 uc291klj.1 uc291klj.2 
ENSMUST00000083731.3 Gm22577 ENSMUST00000083731.3 Gm22577 (from geneSymbol) ENSMUST00000083731.1 ENSMUST00000083731.2 uc290hfa.1 uc290hfa.2 uc290hfa.1 uc290hfa.2 
ENSMUST00000083733.3 Gm22576 ENSMUST00000083733.3 Gm22576 (from geneSymbol) ENSMUST00000083733.1 ENSMUST00000083733.2 uc289eyj.1 uc289eyj.2 uc289eyj.1 uc289eyj.2 
ENSMUST00000083735.3 Gm22581 ENSMUST00000083735.3 Gm22581 (from geneSymbol) ENSMUST00000083735.1 ENSMUST00000083735.2 uc290hvs.1 uc290hvs.2 uc290hvs.1 uc290hvs.2 
ENSMUST00000083739.3 Gm24258 ENSMUST00000083739.3 Gm24258 (from geneSymbol) ENSMUST00000083739.1 ENSMUST00000083739.2 uc288vhj.1 uc288vhj.2 uc288vhj.1 uc288vhj.2 
ENSMUST00000083740.3 Gm24259 ENSMUST00000083740.3 Gm24259 (from geneSymbol) ENSMUST00000083740.1 ENSMUST00000083740.2 uc292lik.1 uc292lik.2 uc292lik.1 uc292lik.2 
ENSMUST00000083742.3 Snord42b ENSMUST00000083742.3 small nucleolar RNA, C/D box 42B (from RefSeq NR_037683.1) ENSMUST00000083742.1 ENSMUST00000083742.2 NR_037683 uc011yah.1 uc011yah.2 uc011yah.3 uc011yah.1 uc011yah.2 uc011yah.3 
ENSMUST00000083744.3 Gm24261 ENSMUST00000083744.3 Gm24261 (from geneSymbol) DQ558729 ENSMUST00000083744.1 ENSMUST00000083744.2 uc288poc.1 uc288poc.2 uc288poc.1 uc288poc.2 
ENSMUST00000083746.4 Snord38a ENSMUST00000083746.4 small nucleolar RNA, C/D box 38A (from RefSeq NR_028524.1) ENSMUST00000083746.1 ENSMUST00000083746.2 ENSMUST00000083746.3 NR_028524 uc290pcq.1 uc290pcq.2 uc290pcq.1 uc290pcq.2 
ENSMUST00000083750.3 Gm23733 ENSMUST00000083750.3 Gm23733 (from geneSymbol) ENSMUST00000083750.1 ENSMUST00000083750.2 uc290jdd.1 uc290jdd.2 uc290jdd.1 uc290jdd.2 
ENSMUST00000083752.3 Snora5c ENSMUST00000083752.3 small nucleolar RNA, H/ACA box 5C (from RefSeq NR_034042.2) ENSMUST00000083752.1 ENSMUST00000083752.2 NR_034042 uc287woh.1 uc287woh.2 uc287woh.1 uc287woh.2 
ENSMUST00000083753.3 Gm23734 ENSMUST00000083753.3 Gm23734 (from geneSymbol) ENSMUST00000083753.1 ENSMUST00000083753.2 uc287ljm.1 uc287ljm.2 uc287ljm.1 uc287ljm.2 
ENSMUST00000083755.3 n-R5s7 ENSMUST00000083755.3 n-R5s7 (from geneSymbol) ENSMUST00000083755.1 ENSMUST00000083755.2 uc292omm.1 uc292omm.2 uc292omm.1 uc292omm.2 
ENSMUST00000083758.3 Gm25410 ENSMUST00000083758.3 Gm25410 (from geneSymbol) ENSMUST00000083758.1 ENSMUST00000083758.2 uc287pkx.1 uc287pkx.2 uc287pkx.1 uc287pkx.2 
ENSMUST00000083760.3 Gm25411 ENSMUST00000083760.3 Gm25411 (from geneSymbol) ENSMUST00000083760.1 ENSMUST00000083760.2 uc287iwv.1 uc287iwv.2 uc287iwv.1 uc287iwv.2 
ENSMUST00000083764.3 Gm25409 ENSMUST00000083764.3 Gm25409 (from geneSymbol) ENSMUST00000083764.1 ENSMUST00000083764.2 uc291szv.1 uc291szv.2 uc291szv.1 uc291szv.2 
ENSMUST00000083766.3 Gm22827 ENSMUST00000083766.3 Gm22827 (from geneSymbol) ENSMUST00000083766.1 ENSMUST00000083766.2 uc292dhq.1 uc292dhq.2 uc292dhq.1 uc292dhq.2 
ENSMUST00000083767.3 Rny1 ENSMUST00000083767.3 Rny1 (from geneSymbol) ENSMUST00000083767.1 ENSMUST00000083767.2 U34828 uc057lpx.1 uc057lpx.2 uc057lpx.3 uc057lpx.1 uc057lpx.2 uc057lpx.3 
ENSMUST00000083768.3 Gm22828 ENSMUST00000083768.3 Gm22828 (from geneSymbol) ENSMUST00000083768.1 ENSMUST00000083768.2 uc291cur.1 uc291cur.2 uc291cur.1 uc291cur.2 
ENSMUST00000083771.3 Gm22829 ENSMUST00000083771.3 Gm22829 (from geneSymbol) DQ558729 ENSMUST00000083771.1 ENSMUST00000083771.2 uc287rul.1 uc287rul.2 uc287rul.1 uc287rul.2 
ENSMUST00000083772.3 Gm22830 ENSMUST00000083772.3 Gm22830 (from geneSymbol) ENSMUST00000083772.1 ENSMUST00000083772.2 uc292jhs.1 uc292jhs.2 uc292jhs.1 uc292jhs.2 
ENSMUST00000083774.3 Gm22826 ENSMUST00000083774.3 Gm22826 (from geneSymbol) ENSMUST00000083774.1 ENSMUST00000083774.2 uc290ieb.1 uc290ieb.2 uc290ieb.1 uc290ieb.2 
ENSMUST00000083775.3 Gm22341 ENSMUST00000083775.3 Gm22341 (from geneSymbol) ENSMUST00000083775.1 ENSMUST00000083775.2 uc290hzl.1 uc290hzl.2 uc290hzl.1 uc290hzl.2 
ENSMUST00000083780.3 Gm25652 ENSMUST00000083780.3 Gm25652 (from geneSymbol) ENSMUST00000083780.1 ENSMUST00000083780.2 uc288wta.1 uc288wta.2 uc288wta.1 uc288wta.2 
ENSMUST00000083781.3 Snord7 ENSMUST00000083781.3 small nucleolar RNA, C/D box 7 (from RefSeq NR_028362.1) ENSMUST00000083781.1 ENSMUST00000083781.2 NR_028362 uc011ybh.1 uc011ybh.2 uc011ybh.3 uc011ybh.1 uc011ybh.2 uc011ybh.3 
ENSMUST00000083782.4 Gm25651 ENSMUST00000083782.4 Gm25651 (from geneSymbol) ENSMUST00000083782.1 ENSMUST00000083782.2 ENSMUST00000083782.3 uc292rum.1 uc292rum.2 uc292rum.1 uc292rum.2 
ENSMUST00000083784.3 Gm25650 ENSMUST00000083784.3 Gm25650 (from geneSymbol) ENSMUST00000083784.1 ENSMUST00000083784.2 uc287qzt.1 uc287qzt.2 uc287qzt.1 uc287qzt.2 
ENSMUST00000083785.3 n-R5s12 ENSMUST00000083785.3 n-R5s12 (from geneSymbol) ENSMUST00000083785.1 ENSMUST00000083785.2 uc292qqe.1 uc292qqe.2 uc292qqe.1 uc292qqe.2 
ENSMUST00000083787.3 Gm26168 ENSMUST00000083787.3 Gm26168 (from geneSymbol) ENSMUST00000083787.1 ENSMUST00000083787.2 uc291ipo.1 uc291ipo.2 uc291ipo.1 uc291ipo.2 
ENSMUST00000083788.3 Gm26166 ENSMUST00000083788.3 Gm26166 (from geneSymbol) ENSMUST00000083788.1 ENSMUST00000083788.2 uc290flg.1 uc290flg.2 uc290flg.1 uc290flg.2 
ENSMUST00000083791.3 Gm26165 ENSMUST00000083791.3 Gm26165 (from geneSymbol) ENSMUST00000083791.1 ENSMUST00000083791.2 uc290azk.1 uc290azk.2 uc290azk.1 uc290azk.2 
ENSMUST00000083792.3 Gm26163 ENSMUST00000083792.3 Gm26163 (from geneSymbol) ENSMUST00000083792.1 ENSMUST00000083792.2 uc288xiv.1 uc288xiv.2 uc288xiv.1 uc288xiv.2 
ENSMUST00000083793.3 Gm26164 ENSMUST00000083793.3 Gm26164 (from geneSymbol) ENSMUST00000083793.1 ENSMUST00000083793.2 uc292aci.1 uc292aci.2 uc292aci.1 uc292aci.2 
ENSMUST00000083794.3 Gm26175 ENSMUST00000083794.3 Gm26175 (from geneSymbol) ENSMUST00000083794.1 ENSMUST00000083794.2 uc291hii.1 uc291hii.2 uc291hii.1 uc291hii.2 
ENSMUST00000083795.3 Gm26176 ENSMUST00000083795.3 Gm26176 (from geneSymbol) ENSMUST00000083795.1 ENSMUST00000083795.2 uc291rlc.1 uc291rlc.2 uc291rlc.1 uc291rlc.2 
ENSMUST00000083798.3 Gm24492 ENSMUST00000083798.3 Gm24492 (from geneSymbol) DQ558729 ENSMUST00000083798.1 ENSMUST00000083798.2 uc289nff.1 uc289nff.2 uc289nff.1 uc289nff.2 
ENSMUST00000083799.3 Gm24491 ENSMUST00000083799.3 Gm24491 (from geneSymbol) ENSMUST00000083799.1 ENSMUST00000083799.2 uc292qbl.1 uc292qbl.2 uc292qbl.1 uc292qbl.2 
ENSMUST00000083800.3 Snord49a ENSMUST00000083800.3 small nucleolar RNA, C/D box 49A (from RefSeq NR_028550.1) ENSMUST00000083800.1 ENSMUST00000083800.2 NR_028550 uc011xwd.1 uc011xwd.2 uc011xwd.3 uc011xwd.1 uc011xwd.2 uc011xwd.3 
ENSMUST00000083801.3 Snord80 ENSMUST00000083801.3 Snord80 (from geneSymbol) ENSMUST00000083801.1 ENSMUST00000083801.2 uc287ncj.1 uc287ncj.2 uc287ncj.1 uc287ncj.2 
ENSMUST00000083803.3 Gm24490 ENSMUST00000083803.3 Gm24490 (from geneSymbol) ENSMUST00000083803.1 ENSMUST00000083803.2 uc292bub.1 uc292bub.2 uc292bub.1 uc292bub.2 
ENSMUST00000083804.3 Gm24494 ENSMUST00000083804.3 Gm24494 (from geneSymbol) ENSMUST00000083804.1 ENSMUST00000083804.2 uc290ksj.1 uc290ksj.2 uc290ksj.1 uc290ksj.2 
ENSMUST00000083805.3 Gm26494 ENSMUST00000083805.3 Gm26494 (from geneSymbol) ENSMUST00000083805.1 ENSMUST00000083805.2 uc292nuj.1 uc292nuj.2 uc292nuj.1 uc292nuj.2 
ENSMUST00000083808.4 Gm25007 ENSMUST00000083808.4 Gm25007 (from geneSymbol) DQ562105 ENSMUST00000083808.1 ENSMUST00000083808.2 ENSMUST00000083808.3 uc288xzc.1 uc288xzc.2 uc288xzc.1 uc288xzc.2 
ENSMUST00000083809.4 Gm25008 ENSMUST00000083809.4 Gm25008 (from geneSymbol) ENSMUST00000083809.1 ENSMUST00000083809.2 ENSMUST00000083809.3 uc289ljb.1 uc289ljb.2 uc289ljb.1 uc289ljb.2 
ENSMUST00000083811.4 Gm25004 ENSMUST00000083811.4 Gm25004 (from geneSymbol) ENSMUST00000083811.1 ENSMUST00000083811.2 ENSMUST00000083811.3 uc290nvr.1 uc290nvr.2 uc290nvr.1 uc290nvr.2 
ENSMUST00000083812.3 Gm25005 ENSMUST00000083812.3 Gm25005 (from geneSymbol) ENSMUST00000083812.1 ENSMUST00000083812.2 uc289pvs.1 uc289pvs.2 uc289pvs.1 uc289pvs.2 
ENSMUST00000083813.3 Gm25006 ENSMUST00000083813.3 Gm25006 (from geneSymbol) ENSMUST00000083813.1 ENSMUST00000083813.2 uc292pih.1 uc292pih.2 uc292pih.1 uc292pih.2 
ENSMUST00000083815.3 AF357428 ENSMUST00000083815.3 AF357428 (from geneSymbol) ENSMUST00000083815.1 ENSMUST00000083815.2 uc288jes.1 uc288jes.2 uc288jes.1 uc288jes.2 
ENSMUST00000083816.3 Gm23346 ENSMUST00000083816.3 Gm23346 (from geneSymbol) ENSMUST00000083816.1 ENSMUST00000083816.2 LF195545 uc291fpq.1 uc291fpq.2 uc291fpq.1 uc291fpq.2 
ENSMUST00000083817.3 Gm23345 ENSMUST00000083817.3 Gm23345 (from geneSymbol) DQ562105 ENSMUST00000083817.1 ENSMUST00000083817.2 uc291unk.1 uc291unk.2 uc291unk.1 uc291unk.2 
ENSMUST00000083818.3 Gm23344 ENSMUST00000083818.3 Gm23344 (from geneSymbol) ENSMUST00000083818.1 ENSMUST00000083818.2 uc292icc.1 uc292icc.2 uc292icc.1 uc292icc.2 
ENSMUST00000083820.4 Gm22723 ENSMUST00000083820.4 Gm22723 (from geneSymbol) ENSMUST00000083820.1 ENSMUST00000083820.2 ENSMUST00000083820.3 uc291eyk.1 uc291eyk.2 uc291eyk.1 uc291eyk.2 
ENSMUST00000083823.3 Gm23347 ENSMUST00000083823.3 Gm23347 (from geneSymbol) ENSMUST00000083823.1 ENSMUST00000083823.2 LF199330 uc288jer.1 uc288jer.2 uc288jer.1 uc288jer.2 
ENSMUST00000083826.3 Gm23848 ENSMUST00000083826.3 Gm23848 (from geneSymbol) ENSMUST00000083826.1 ENSMUST00000083826.2 uc288xzi.1 uc288xzi.2 uc288xzi.1 uc288xzi.2 
ENSMUST00000083829.3 Gm23847 ENSMUST00000083829.3 Gm23847 (from geneSymbol) ENSMUST00000083829.1 ENSMUST00000083829.2 uc291wel.1 uc291wel.2 uc291wel.1 uc291wel.2 
ENSMUST00000083830.3 Gm23850 ENSMUST00000083830.3 Gm23850 (from geneSymbol) ENSMUST00000083830.1 ENSMUST00000083830.2 uc290ghu.1 uc290ghu.2 uc290ghu.1 uc290ghu.2 
ENSMUST00000083831.4 Gm23851 ENSMUST00000083831.4 Gm23851 (from geneSymbol) ENSMUST00000083831.1 ENSMUST00000083831.2 ENSMUST00000083831.3 uc291ixg.1 uc291ixg.2 uc291ixg.1 uc291ixg.2 
ENSMUST00000083834.3 Gm23845 ENSMUST00000083834.3 Gm23845 (from geneSymbol) ENSMUST00000083834.1 ENSMUST00000083834.2 uc290qfc.1 uc290qfc.2 uc290qfc.1 uc290qfc.2 
ENSMUST00000083836.4 Gm23510 ENSMUST00000083836.4 Gm23510 (from geneSymbol) ENSMUST00000083836.1 ENSMUST00000083836.2 ENSMUST00000083836.3 uc291clb.1 uc291clb.2 uc291clb.1 uc291clb.2 
ENSMUST00000083839.3 Gm57479 ENSMUST00000083839.3 Gm57479 (from geneSymbol) DQ548138 ENSMUST00000083839.1 ENSMUST00000083839.2 uc057lgg.1 uc057lgg.2 uc057lgg.1 uc057lgg.2 
ENSMUST00000083844.3 Gm22154 ENSMUST00000083844.3 Gm22154 (from geneSymbol) ENSMUST00000083844.1 ENSMUST00000083844.2 uc290pqe.1 uc290pqe.2 uc290pqe.1 uc290pqe.2 
ENSMUST00000083848.3 Gm22680 ENSMUST00000083848.3 Gm22680 (from geneSymbol) ENSMUST00000083848.1 ENSMUST00000083848.2 uc289qse.1 uc289qse.2 uc289qse.1 uc289qse.2 
ENSMUST00000083853.3 Gm22681 ENSMUST00000083853.3 Gm22681 (from geneSymbol) ENSMUST00000083853.1 ENSMUST00000083853.2 uc287mjf.1 uc287mjf.2 uc287mjf.1 uc287mjf.2 
ENSMUST00000083856.3 Gm24091 ENSMUST00000083856.3 Gm24091 (from geneSymbol) ENSMUST00000083856.1 ENSMUST00000083856.2 uc290qhg.1 uc290qhg.2 uc290qhg.1 uc290qhg.2 
ENSMUST00000083858.3 Gm25515 ENSMUST00000083858.3 Gm25515 (from geneSymbol) ENSMUST00000083858.1 ENSMUST00000083858.2 LF197902 uc287pgj.1 uc287pgj.2 uc287pgj.1 uc287pgj.2 
ENSMUST00000083860.4 Gm25514 ENSMUST00000083860.4 Gm25514 (from geneSymbol) ENSMUST00000083860.1 ENSMUST00000083860.2 ENSMUST00000083860.3 uc289zkt.1 uc289zkt.2 uc289zkt.1 uc289zkt.2 
ENSMUST00000083861.3 Gm25513 ENSMUST00000083861.3 Gm25513 (from geneSymbol) ENSMUST00000083861.1 ENSMUST00000083861.2 uc290vpi.1 uc290vpi.2 uc290vpi.1 uc290vpi.2 
ENSMUST00000083863.3 Gm25512 ENSMUST00000083863.3 Gm25512 (from geneSymbol) ENSMUST00000083863.1 ENSMUST00000083863.2 uc290ckq.1 uc290ckq.2 uc290ckq.1 uc290ckq.2 
ENSMUST00000083864.3 Gm25518 ENSMUST00000083864.3 Gm25518 (from geneSymbol) DQ558729 ENSMUST00000083864.1 ENSMUST00000083864.2 uc289tss.1 uc289tss.2 uc289tss.1 uc289tss.2 
ENSMUST00000083865.3 Gm25517 ENSMUST00000083865.3 Gm25517 (from geneSymbol) ENSMUST00000083865.1 ENSMUST00000083865.2 uc288vtb.1 uc288vtb.2 uc288vtb.1 uc288vtb.2 
ENSMUST00000083866.3 Gm23042 ENSMUST00000083866.3 Gm23042 (from geneSymbol) DQ558729 ENSMUST00000083866.1 ENSMUST00000083866.2 uc291rbj.1 uc291rbj.2 uc291rbj.1 uc291rbj.2 
ENSMUST00000083868.3 Gm23041 ENSMUST00000083868.3 Gm23041 (from geneSymbol) ENSMUST00000083868.1 ENSMUST00000083868.2 uc287utj.1 uc287utj.2 uc287utj.1 uc287utj.2 
ENSMUST00000083869.4 Gm23040 ENSMUST00000083869.4 Gm23040 (from geneSymbol) ENSMUST00000083869.1 ENSMUST00000083869.2 ENSMUST00000083869.3 uc291swv.1 uc291swv.2 uc291swv.1 uc291swv.2 
ENSMUST00000083870.3 Gm23039 ENSMUST00000083870.3 Gm23039 (from geneSymbol) ENSMUST00000083870.1 ENSMUST00000083870.2 uc287xqp.1 uc287xqp.2 uc287xqp.1 uc287xqp.2 
ENSMUST00000083873.3 Gm23038 ENSMUST00000083873.3 Gm23038 (from geneSymbol) ENSMUST00000083873.1 ENSMUST00000083873.2 uc290kuj.1 uc290kuj.2 uc290kuj.1 uc290kuj.2 
ENSMUST00000083877.4 Gm24695 ENSMUST00000083877.4 Gm24695 (from geneSymbol) ENSMUST00000083877.1 ENSMUST00000083877.2 ENSMUST00000083877.3 uc289fzz.1 uc289fzz.2 uc289fzz.1 uc289fzz.2 
ENSMUST00000083878.3 Gm24696 ENSMUST00000083878.3 Gm24696 (from geneSymbol) ENSMUST00000083878.1 ENSMUST00000083878.2 uc288ygw.1 uc288ygw.2 uc288ygw.1 uc288ygw.2 
ENSMUST00000083881.3 Gm24697 ENSMUST00000083881.3 Gm24697 (from geneSymbol) ENSMUST00000083881.1 ENSMUST00000083881.2 uc290nfz.1 uc290nfz.2 uc290nfz.1 uc290nfz.2 
ENSMUST00000083883.3 Gm24698 ENSMUST00000083883.3 Gm24698 (from geneSymbol) ENSMUST00000083883.1 ENSMUST00000083883.2 uc291ykm.1 uc291ykm.2 uc291ykm.1 uc291ykm.2 
ENSMUST00000083884.3 Snord35a ENSMUST00000083884.3 small nucleolar RNA, C/D box 35A (from RefSeq NR_000003.8) ENSMUST00000083884.1 ENSMUST00000083884.2 NR_000003 uc009gtl.1 uc009gtl.2 uc009gtl.3 uc009gtl.1 uc009gtl.2 uc009gtl.3 
ENSMUST00000083888.3 Snord15a ENSMUST00000083888.3 small nucleolar RNA, C/D box 15A (from RefSeq NR_002172.1) ENSMUST00000083888.1 ENSMUST00000083888.2 NR_002172 uc009ilt.1 uc009ilt.2 uc009ilt.1 uc009ilt.2 
ENSMUST00000083891.3 Gm26314 ENSMUST00000083891.3 Gm26314 (from geneSymbol) ENSMUST00000083891.1 ENSMUST00000083891.2 uc292nfv.1 uc292nfv.2 uc292nfv.1 uc292nfv.2 
ENSMUST00000083895.3 Snord16a ENSMUST00000083895.3 small nucleolar RNA, C/D box 16A (from RefSeq NR_028548.1) ENSMUST00000083895.1 ENSMUST00000083895.2 NR_028548 uc292icd.1 uc292icd.2 uc292icd.1 uc292icd.2 
ENSMUST00000083902.4 Gm23502 ENSMUST00000083902.4 Gm23502 (from geneSymbol) ENSMUST00000083902.1 ENSMUST00000083902.2 ENSMUST00000083902.3 uc288rkz.1 uc288rkz.2 uc288rkz.1 uc288rkz.2 
ENSMUST00000083903.3 Gm23503 ENSMUST00000083903.3 Gm23503 (from geneSymbol) ENSMUST00000083903.1 ENSMUST00000083903.2 uc289wlk.1 uc289wlk.2 uc289wlk.1 uc289wlk.2 
ENSMUST00000083906.3 Gm25187 ENSMUST00000083906.3 Gm25187 (from geneSymbol) ENSMUST00000083906.1 ENSMUST00000083906.2 uc290cdi.1 uc290cdi.2 uc290cdi.1 uc290cdi.2 
ENSMUST00000083907.4 Gm25257 ENSMUST00000083907.4 Gm25257 (from geneSymbol) ENSMUST00000083907.1 ENSMUST00000083907.2 ENSMUST00000083907.3 uc292riy.1 uc292riy.2 uc292riy.1 uc292riy.2 
ENSMUST00000083909.3 Gm25186 ENSMUST00000083909.3 Gm25186 (from geneSymbol) ENSMUST00000083909.1 ENSMUST00000083909.2 uc288lts.1 uc288lts.2 uc288lts.1 uc288lts.2 
ENSMUST00000083911.3 Gm25189 ENSMUST00000083911.3 Gm25189 (from geneSymbol) AB351594 ENSMUST00000083911.1 ENSMUST00000083911.2 uc289zkx.1 uc289zkx.2 uc289zkx.1 uc289zkx.2 
ENSMUST00000083913.3 Gm25188 ENSMUST00000083913.3 Gm25188 (from geneSymbol) ENSMUST00000083913.1 ENSMUST00000083913.2 uc290ghm.1 uc290ghm.2 uc290ghm.1 uc290ghm.2 
ENSMUST00000083918.3 Gm22353 ENSMUST00000083918.3 Gm22353 (from geneSymbol) ENSMUST00000083918.1 ENSMUST00000083918.2 LF200225 uc288xsm.1 uc288xsm.2 uc288xsm.1 uc288xsm.2 
ENSMUST00000083919.3 Gm22354 ENSMUST00000083919.3 Gm22354 (from geneSymbol) AF357379 ENSMUST00000083919.1 ENSMUST00000083919.2 uc288tss.1 uc288tss.2 uc288tss.1 uc288tss.2 
ENSMUST00000083924.3 Gm22350 ENSMUST00000083924.3 Gm22350 (from geneSymbol) ENSMUST00000083924.1 ENSMUST00000083924.2 uc288rch.1 uc288rch.2 uc288rch.1 uc288rch.2 
ENSMUST00000083925.4 Gm22351 ENSMUST00000083925.4 Gm22351 (from geneSymbol) DQ558729 ENSMUST00000083925.1 ENSMUST00000083925.2 ENSMUST00000083925.3 uc292pao.1 uc292pao.2 uc292pao.1 uc292pao.2 
ENSMUST00000083928.3 Gm24029 ENSMUST00000083928.3 Gm24029 (from geneSymbol) ENSMUST00000083928.1 ENSMUST00000083928.2 uc287ziq.1 uc287ziq.2 uc287ziq.1 uc287ziq.2 
ENSMUST00000083930.3 Gm24031 ENSMUST00000083930.3 Gm24031 (from geneSymbol) ENSMUST00000083930.1 ENSMUST00000083930.2 uc288rrz.1 uc288rrz.2 uc288rrz.1 uc288rrz.2 
ENSMUST00000083931.3 Gm24030 ENSMUST00000083931.3 Gm24030 (from geneSymbol) ENSMUST00000083931.1 ENSMUST00000083931.2 uc287lao.1 uc287lao.2 uc287lao.1 uc287lao.2 
ENSMUST00000083932.3 Gm24032 ENSMUST00000083932.3 Gm24032 (from geneSymbol) ENSMUST00000083932.1 ENSMUST00000083932.2 uc288pgs.1 uc288pgs.2 uc288pgs.1 uc288pgs.2 
ENSMUST00000083935.3 Gm24917 ENSMUST00000083935.3 Gm24917 (from geneSymbol) DQ558729 ENSMUST00000083935.1 ENSMUST00000083935.2 uc287wxy.1 uc287wxy.2 uc287wxy.1 uc287wxy.2 
ENSMUST00000083938.3 Gm25681 ENSMUST00000083938.3 Gm25681 (from geneSymbol) DQ558729 ENSMUST00000083938.1 ENSMUST00000083938.2 uc290ivt.1 uc290ivt.2 uc290ivt.1 uc290ivt.2 
ENSMUST00000083940.3 Gm25683 ENSMUST00000083940.3 Gm25683 (from geneSymbol) ENSMUST00000083940.1 ENSMUST00000083940.2 uc291uur.1 uc291uur.2 uc291uur.1 uc291uur.2 
ENSMUST00000083942.3 Gm25682 ENSMUST00000083942.3 Gm25682 (from geneSymbol) AB349399 ENSMUST00000083942.1 ENSMUST00000083942.2 uc287pmh.1 uc287pmh.2 uc287pmh.1 uc287pmh.2 
ENSMUST00000083944.3 Snord34 ENSMUST00000083944.3 small nucleolar RNA, C/D box 34 (from RefSeq NR_002455.1) ENSMUST00000083944.1 ENSMUST00000083944.2 NR_002455 uc012fkc.1 uc012fkc.2 uc012fkc.3 uc012fkc.1 uc012fkc.2 uc012fkc.3 
ENSMUST00000083947.3 Gm22866 ENSMUST00000083947.3 Gm22866 (from geneSymbol) AB353021 ENSMUST00000083947.1 ENSMUST00000083947.2 uc292jpd.1 uc292jpd.2 uc292jpd.1 uc292jpd.2 
ENSMUST00000083949.4 Snord3b-ps2 ENSMUST00000083949.4 Snord3b-ps2 (from geneSymbol) ENSMUST00000083949.1 ENSMUST00000083949.2 ENSMUST00000083949.3 uc289zva.1 uc289zva.2 uc289zva.1 uc289zva.2 
ENSMUST00000083953.2 n-R5s185 ENSMUST00000083953.2 n-R5s185 (from geneSymbol) AB349563 ENSMUST00000083953.1 uc290mud.1 uc290mud.2 uc290mud.1 uc290mud.2 
ENSMUST00000083958.3 Gm24521 ENSMUST00000083958.3 Gm24521 (from geneSymbol) DQ558729 ENSMUST00000083958.1 ENSMUST00000083958.2 uc289rcp.1 uc289rcp.2 uc289rcp.1 uc289rcp.2 
ENSMUST00000083959.3 n-R5s151 ENSMUST00000083959.3 n-R5s151 (from geneSymbol) AB352541 ENSMUST00000083959.1 ENSMUST00000083959.2 uc291mbe.1 uc291mbe.2 uc291mbe.1 uc291mbe.2 
ENSMUST00000083964.3 Gm24522 ENSMUST00000083964.3 Gm24522 (from geneSymbol) ENSMUST00000083964.1 ENSMUST00000083964.2 uc292qkp.1 uc292qkp.2 uc292qkp.1 uc292qkp.2 
ENSMUST00000083965.3 Gm24523 ENSMUST00000083965.3 Gm24523 (from geneSymbol) ENSMUST00000083965.1 ENSMUST00000083965.2 uc288xmi.1 uc288xmi.2 uc288xmi.1 uc288xmi.2 
ENSMUST00000083969.3 Gm26111 ENSMUST00000083969.3 Gm26111 (from geneSymbol) ENSMUST00000083969.1 ENSMUST00000083969.2 uc292oku.1 uc292oku.2 uc292oku.1 uc292oku.2 
ENSMUST00000083970.3 Gm26109 ENSMUST00000083970.3 Gm26109 (from geneSymbol) ENSMUST00000083970.1 ENSMUST00000083970.2 uc289oqv.1 uc289oqv.2 uc289oqv.1 uc289oqv.2 
ENSMUST00000083971.3 Gm26110 ENSMUST00000083971.3 Gm26110 (from geneSymbol) AB351594 ENSMUST00000083971.1 ENSMUST00000083971.2 uc287nqz.1 uc287nqz.2 uc287nqz.1 uc287nqz.2 
ENSMUST00000083973.3 Gm26108 ENSMUST00000083973.3 Gm26108 (from geneSymbol) ENSMUST00000083973.1 ENSMUST00000083973.2 uc292qdi.1 uc292qdi.2 uc292qdi.1 uc292qdi.2 
ENSMUST00000083979.4 Gm24448 ENSMUST00000083979.4 Gm24448 (from geneSymbol) DQ558729 ENSMUST00000083979.1 ENSMUST00000083979.2 ENSMUST00000083979.3 uc290net.1 uc290net.2 uc290net.1 uc290net.2 
ENSMUST00000083982.3 Gm24446 ENSMUST00000083982.3 Gm24446 (from geneSymbol) ENSMUST00000083982.1 ENSMUST00000083982.2 uc287xlr.1 uc287xlr.2 uc287xlr.1 uc287xlr.2 
ENSMUST00000083985.3 Gm24449 ENSMUST00000083985.3 Gm24449 (from geneSymbol) DQ558729 ENSMUST00000083985.1 ENSMUST00000083985.2 uc288gxj.1 uc288gxj.2 uc288gxj.1 uc288gxj.2 
ENSMUST00000083990.3 Gm22797 ENSMUST00000083990.3 Gm22797 (from geneSymbol) ENSMUST00000083990.1 ENSMUST00000083990.2 uc289fla.1 uc289fla.2 uc289fla.1 uc289fla.2 
ENSMUST00000084000.3 Gm25630 ENSMUST00000084000.3 Gm25630 (from geneSymbol) ENSMUST00000084000.1 ENSMUST00000084000.2 uc292frd.1 uc292frd.2 uc292frd.1 uc292frd.2 
ENSMUST00000084002.3 Gm25628 ENSMUST00000084002.3 Gm25628 (from geneSymbol) DQ558729 ENSMUST00000084002.1 ENSMUST00000084002.2 uc288yjc.1 uc288yjc.2 uc288yjc.1 uc288yjc.2 
ENSMUST00000084003.4 Gm25627 ENSMUST00000084003.4 Gm25627 (from geneSymbol) ENSMUST00000084003.1 ENSMUST00000084003.2 ENSMUST00000084003.3 uc290kjq.1 uc290kjq.2 uc290kjq.1 uc290kjq.2 
ENSMUST00000084005.3 Snora2b ENSMUST00000084005.3 small nucleolar RNA, H/ACA box 2B (from RefSeq NR_034052.1) ENSMUST00000084005.1 ENSMUST00000084005.2 NR_034052 uc011zyx.1 uc011zyx.2 uc011zyx.3 uc011zyx.1 uc011zyx.2 uc011zyx.3 
ENSMUST00000084006.3 Gm23795 ENSMUST00000084006.3 Gm23795 (from geneSymbol) ENSMUST00000084006.1 ENSMUST00000084006.2 uc291rgk.1 uc291rgk.2 uc291rgk.1 uc291rgk.2 
ENSMUST00000084007.4 Gm24924 ENSMUST00000084007.4 Gm24924 (from geneSymbol) ENSMUST00000084007.1 ENSMUST00000084007.2 ENSMUST00000084007.3 LF204742 uc289oek.1 uc289oek.2 uc289oek.1 uc289oek.2 
ENSMUST00000084009.3 Gm23794 ENSMUST00000084009.3 Gm23794 (from geneSymbol) ENSMUST00000084009.1 ENSMUST00000084009.2 uc292rou.1 uc292rou.2 uc292rou.1 uc292rou.2 
ENSMUST00000084010.3 Gm23444 ENSMUST00000084010.3 Gm23444 (from geneSymbol) DQ551040 ENSMUST00000084010.1 ENSMUST00000084010.2 uc057kml.1 uc057kml.2 uc057kml.3 uc057kml.1 uc057kml.2 uc057kml.3 
ENSMUST00000084011.4 Gm23796 ENSMUST00000084011.4 Gm23796 (from geneSymbol) ENSMUST00000084011.1 ENSMUST00000084011.2 ENSMUST00000084011.3 uc290euw.1 uc290euw.2 uc290euw.1 uc290euw.2 
ENSMUST00000084013.1 mt-Nd4l ENSMUST00000084013.1 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. (from UniProt Q9MD77) AK140187 ND4L Nd4l Q9MD77 Q9MD77_MOUSE mt-ND4L mt-Nd4 mt-Nd4l uc009vfb.1 uc009vfb.2 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence= Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Membrane ; Multi- pass membrane protein Mitochondrion inner membrane ulti-pass membrane protein Belongs to the complex I subunit 4L family. mitochondrion NADH dehydrogenase (ubiquinone) activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on NAD(P)H mitochondrial membrane ATP synthesis coupled electron transport oxidation-reduction process respiratory chain uc009vfb.1 uc009vfb.2 
ENSMUST00000084031.6 Htra4 ENSMUST00000084031.6 HtrA serine peptidase 4 (from RefSeq NM_001081187.3) A2RT60 ENSMUST00000084031.1 ENSMUST00000084031.2 ENSMUST00000084031.3 ENSMUST00000084031.4 ENSMUST00000084031.5 HTRA4_MOUSE NM_001081187 uc009lfp.1 uc009lfp.2 uc009lfp.3 uc009lfp.4 Serine protease. Secreted Belongs to the peptidase S1C family. endopeptidase activity serine-type endopeptidase activity insulin-like growth factor binding cellular_component extracellular region proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009lfp.1 uc009lfp.2 uc009lfp.3 uc009lfp.4 
ENSMUST00000084040.3 Defa37 ENSMUST00000084040.3 defensin, alpha, 37 (from RefSeq NM_001177522.1) Defa36 Defa37 ENSMUST00000084040.1 ENSMUST00000084040.2 K9J724 K9J724_MOUSE NM_001177522 uc012gax.1 uc012gax.2 uc012gax.3 Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc012gax.1 uc012gax.2 uc012gax.3 
ENSMUST00000084041.4 Defa32 ENSMUST00000084041.4 defensin, alpha, 32 (from RefSeq NM_001177521.1) DFA20_MOUSE Defa20 Defcr20 ENSMUST00000084041.1 ENSMUST00000084041.2 ENSMUST00000084041.3 NM_001177521 Q45VN2 Q8BH68 uc009lbr.1 uc009lbr.2 uc009lbr.3 uc009lbr.4 May have microbicidal activities. Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc009lbr.1 uc009lbr.2 uc009lbr.3 uc009lbr.4 
ENSMUST00000084042.4 Defa20 ENSMUST00000084042.4 defensin, alpha, 20 (from RefSeq NM_183268.4) DFA20_MOUSE Defcr20 ENSMUST00000084042.1 ENSMUST00000084042.2 ENSMUST00000084042.3 NM_183268 Q45VN2 Q8BH68 uc009lbq.1 uc009lbq.2 uc009lbq.3 May have microbicidal activities. Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc009lbq.1 uc009lbq.2 uc009lbq.3 
ENSMUST00000084046.6 Potefam3a ENSMUST00000084046.6 POTE ankyrin domain family member 3A (from RefSeq NM_001177408.1) E9Q637 E9Q637_MOUSE ENSMUST00000084046.1 ENSMUST00000084046.2 ENSMUST00000084046.3 ENSMUST00000084046.4 ENSMUST00000084046.5 Gm15319 NM_001177408 Potefam3a uc012gaj.1 uc012gaj.2 uc012gaj.3 molecular_function cellular_component biological_process uc012gaj.1 uc012gaj.2 uc012gaj.3 
ENSMUST00000084086.9 Cd209b ENSMUST00000084086.9 CD209b antigen, transcript variant 1 (from RefSeq NM_026972.5) C209B_MOUSE ENSMUST00000084086.1 ENSMUST00000084086.2 ENSMUST00000084086.3 ENSMUST00000084086.4 ENSMUST00000084086.5 ENSMUST00000084086.6 ENSMUST00000084086.7 ENSMUST00000084086.8 NM_026972 Q8BGZ0 Q8BHK7 Q8CJ86 Q8CJ87 Q8CJ88 Q8CJ89 Q8CJ90 Q8CJ91 Q8CJ92 Q8CJ93 Q8CJ94 Q91ZW4 Q91ZX0 Q9D8V4 uc009ksu.1 uc009ksu.2 uc009ksu.3 uc009ksu.4 Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=alpha; IsoId=Q8CJ91-1; Sequence=Displayed; Name=2; Synonyms=beta, TM-less; IsoId=Q8CJ91-2; Sequence=VSP_010069; Name=3; Synonyms=gamma; IsoId=Q8CJ91-3; Sequence=VSP_010069, VSP_010070; Name=4; IsoId=Q8CJ91-4; Sequence=VSP_010068; Expressed in skin, spleen and lung, probably in a subset of dendritic cells. Detected in spleen extrafollicular paracortical areas including the red pulp and marginal zones, and at lower levels, in the follicular area. Detected in skin suprabasal areas adjacent to the epidermis and in epidermal cell layer. In vitro, is a receptor for HIV-1, HIV-2 and SIV, but does not transmit virus to permissive T-cells under the conditions tested. In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified. Sequence=BAB25166.1; Type=Erroneous initiation; Evidence=; Name=Functional Glycomics Gateway - Glycan Binding; Note=SIGNR1; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_00131"; (1->3)-beta-D-glucan binding detection of yeast mannose binding endocytosis phagocytosis, recognition external side of plasma membrane membrane integral component of membrane detection of bacterium carbohydrate binding polysaccharide binding positive regulation of tumor necrosis factor biosynthetic process metal ion binding positive regulation of phagocytosis uc009ksu.1 uc009ksu.2 uc009ksu.3 uc009ksu.4 
ENSMUST00000084097.12 Aurkaip1 ENSMUST00000084097.12 aurora kinase A interacting protein 1 (from RefSeq NM_025338.4) AKIP_MOUSE Aip Akip ENSMUST00000084097.1 ENSMUST00000084097.10 ENSMUST00000084097.11 ENSMUST00000084097.2 ENSMUST00000084097.3 ENSMUST00000084097.4 ENSMUST00000084097.5 ENSMUST00000084097.6 ENSMUST00000084097.7 ENSMUST00000084097.8 ENSMUST00000084097.9 Mrps38 NM_025338 Q9D1J7 Q9DCJ7 uc008wey.1 uc008wey.2 uc008wey.3 uc008wey.4 May act as a negative regulator of Aurora-A kinase, by down- regulation through proteasome-dependent degradation. Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins (By similarity). Interacts with Aurora-A. Mitochondrion matrix Nucleus Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis. Belongs to the mitochondrion-specific ribosomal protein mS38 family. molecular_function nucleus nucleoplasm anaphase-promoting complex mitochondrion ribosome mRNA processing protein ubiquitination intracellular membrane-bounded organelle positive regulation of proteolysis ubiquitin-protein transferase activity uc008wey.1 uc008wey.2 uc008wey.3 uc008wey.4 
ENSMUST00000084117.13 H6pd ENSMUST00000084117.13 hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase), transcript variant 2 (from RefSeq NM_001291004.1) A2A7A9 B2KGW7 ENSMUST00000084117.1 ENSMUST00000084117.10 ENSMUST00000084117.11 ENSMUST00000084117.12 ENSMUST00000084117.2 ENSMUST00000084117.3 ENSMUST00000084117.4 ENSMUST00000084117.5 ENSMUST00000084117.6 ENSMUST00000084117.7 ENSMUST00000084117.8 ENSMUST00000084117.9 G6PE_MOUSE H6pd NM_001291004 Q8BLH1 Q8CFX1 uc008vxh.1 uc008vxh.2 uc008vxh.3 uc008vxh.4 Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (PubMed:4169027, PubMed:12831846, PubMed:16356929, PubMed:18222920). Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway (PubMed:4169027, PubMed:12831846, PubMed:18222920). In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (PubMed:12831846). May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (PubMed:12831846). The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum (PubMed:12831846, PubMed:16356929, PubMed:17656460, PubMed:18222920). By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta- dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity (PubMed:16356929). Reaction=D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5- lactone + H(+) + NADH; Xref=Rhea:RHEA:38215, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57955, ChEBI:CHEBI:61548; EC=1.1.1.363; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38216; Evidence=; Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5- lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57955, ChEBI:CHEBI:58349, ChEBI:CHEBI:61548; EC=1.1.1.363; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15842; Evidence=; Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12557; Evidence=; Reaction=2-deoxy-D-glucose 6-phosphate + NAD(+) = 2-deoxy-6-phospho-D- glucono-1,5-lactone + H(+) + NADH; Xref=Rhea:RHEA:62064, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:84760, ChEBI:CHEBI:145420; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62065; Evidence=; Reaction=2-deoxy-D-glucose 6-phosphate + NADP(+) = 2-deoxy-6-phospho-D- glucono-1,5-lactone + H(+) + NADPH; Xref=Rhea:RHEA:62068, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:84760, ChEBI:CHEBI:145420; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62069; Evidence=; Reaction=D-galactose 6-phosphate + NADP(+) = 6-phospho-D-galactono-1,5- lactone + H(+) + NADPH; Xref=Rhea:RHEA:62072, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:91004, ChEBI:CHEBI:145419; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62073; Evidence=; Reaction=D-galactose 6-phosphate + NAD(+) = 6-phospho-D-galactono-1,5- lactone + H(+) + NADH; Xref=Rhea:RHEA:62076, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:91004, ChEBI:CHEBI:145419; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62077; Evidence=; Reaction=D-glucosamine 6-phosphate + NADP(+) = 2-amino-2-deoxy-6- phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH; Xref=Rhea:RHEA:62088, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58725, ChEBI:CHEBI:145423; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62089; Evidence=; Reaction=D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH; Xref=Rhea:RHEA:14293, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378, ChEBI:CHEBI:16217, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.47; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14294; Evidence=; Reaction=D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH; Xref=Rhea:RHEA:14405, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378, ChEBI:CHEBI:16217, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.47; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14406; Evidence=; Reaction=D-glucose 6-sulfate + NADP(+) = 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH; Xref=Rhea:RHEA:62080, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:145424, ChEBI:CHEBI:145427; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62081; Evidence=; Kinetic parameters: KM=4065 mM for D-glucose (at pH 7.1 in the presence of NADP) ; KM=725 mM for D-glucose (at pH 7.1 in the presence of NAD) ; KM=532 mM for D-glucose (at pH 9.6 in the presence of NAD) ; KM=120 uM for D-glucose 6-phosphate (at pH 9.6 in the presence of NADP) ; KM=28 uM for D-glucose 6-phosphate (at pH 9.6 in the presence of NAD) ; KM=66 uM for 2-deoxy-D-glucose 6-phosphate (at pH 7.1 in the presence of NADP) ; KM=12 uM for 2-deoxy-D-glucose 6-phosphate (at pH 7.1 in the presence of NAD) ; KM=5.89 mM for 2-deoxy-D-glucose 6-phosphate (at pH 9.6 in the presence of NADP) ; KM=4.35 mM for 2-deoxy-D-glucose 6-phosphate (at pH 9.6 in the presence of NAD) ; KM=7 uM for D-galactopyranose 6-phosphate (at pH 7.1 in the presence of NADP) ; KM=504 uM for D-galactopyranose 6-phosphate (at pH 9.6 in the presence of NADP) ; KM=223 uM for D-galactopyranose 6-phosphate (at pH 7.1 in the presence of NAD) ; KM=9 uM for NADP (at pH 7.1 in the presence of galactose 6-phosphate) ; KM=14 uM for NADP (at pH 9.6 in the presence of galactose 6- phosphate) ; KM=4 uM for NADP (at pH 9.6 in the presence of D-glucose 6-phosphate) ; KM=12 uM for NADP (at pH 7.1 in the presence of D-glucose) ; KM=52 uM for NAD (at pH 7.1 in the presence of D-glucose) ; KM=47 uM for NADP (at pH 9.6 in the presence of D-glucose) ; KM=261 uM for NAD (at pH 9.6 in the presence of D-glucose) ; KM=34 uM for NAD (at pH 7.1 in the presence of D-glucose) ; KM=72 uM for NAD (at pH 9.6 in the presence of D-glucose) ; pH dependence: Optimum pH is 6.0-8.0. ; Carbohydrate degradation; pentose phosphate pathway; D- ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage). Carbohydrate degradation; pentose phosphate pathway; D- ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. Homodimer. Endoplasmic reticulum lumen Expressed in liver (at protein level) (PubMed:4169027). Expressed in muscles (PubMed:18222920). Expressed in adipose tissues (PubMed:18218694). Mice lacking H6pd are born at the expected Mendelian frequency and do not show overt phenotype (PubMed:16356929). However, they display cellular inability to convert 11- dehydrocorticosterone (11-DHC) to corticosterone and present increased corticosterone to 11-DHC conversion associated with adrenal hyperplasia (PubMed:16356929). Mutant mice also display fasting hypoglycemia and perturbed lipid mobilization that are probably due to the aforementioned effect on corticosterone metabolism and blunted intracellular action of the hormone (PubMed:17656460, PubMed:18218694). Skeletal myopathy associated with a dysregulation of the expression of proteins associated with calcium homeostasis in the sarcoplasmic reticulum and an activation of the unfolded protein response are also observed (PubMed:18222920). In the N-terminal section; belongs to the glucose-6- phosphate dehydrogenase family. In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily. Sequence=BAC32260.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; catalytic activity glucose-6-phosphate dehydrogenase activity cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum lumen carbohydrate metabolic process glucose metabolic process pentose-phosphate shunt NADP metabolic process metabolic process oxidoreductase activity sarcoplasmic reticulum oxidoreductase activity, acting on CH-OH group of donors hydrolase activity 6-phosphogluconolactonase activity carbohydrate binding intracellular membrane-bounded organelle glucose 1-dehydrogenase [NAD(P)] activity NADP binding oxidation-reduction process uc008vxh.1 uc008vxh.2 uc008vxh.3 uc008vxh.4 
ENSMUST00000084124.7 Pgd ENSMUST00000084124.7 phosphogluconate dehydrogenase, transcript variant 2 (from RefSeq NM_001356332.1) 6PGD_MOUSE ENSMUST00000084124.1 ENSMUST00000084124.2 ENSMUST00000084124.3 ENSMUST00000084124.4 ENSMUST00000084124.5 ENSMUST00000084124.6 NM_001356332 Q3UD80 Q9DCD0 uc008vvv.1 uc008vvv.2 uc008vvv.3 Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Reaction=6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH; Xref=Rhea:RHEA:10116, ChEBI:CHEBI:16526, ChEBI:CHEBI:57783, ChEBI:CHEBI:58121, ChEBI:CHEBI:58349, ChEBI:CHEBI:58759; EC=1.1.1.44; Carbohydrate degradation; pentose phosphate pathway; D- ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. Homodimer. Cytoplasm Belongs to the 6-phosphogluconate dehydrogenase family. phosphogluconate dehydrogenase (decarboxylating) activity cytoplasm cytosol carbohydrate metabolic process pentose-phosphate shunt NADP metabolic process pentose-phosphate shunt, oxidative branch oxidoreductase activity pentose biosynthetic process D-gluconate metabolic process carbohydrate binding carboxylic acid binding intracellular membrane-bounded organelle D-gluconate catabolic process NADP binding oxidation-reduction process uc008vvv.1 uc008vvv.2 uc008vvv.3 
ENSMUST00000084125.10 Tardbp ENSMUST00000084125.10 TAR DNA binding protein, transcript variant 8 (from RefSeq NR_131120.1) ENSMUST00000084125.1 ENSMUST00000084125.2 ENSMUST00000084125.3 ENSMUST00000084125.4 ENSMUST00000084125.5 ENSMUST00000084125.6 ENSMUST00000084125.7 ENSMUST00000084125.8 ENSMUST00000084125.9 NR_131120 Q3U591 Q3V0E7 Q921F2 TADBP_MOUSE Tdp43 uc008vvg.1 uc008vvg.2 uc008vvg.3 RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (By similarity). Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (By similarity). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). Homodimer. Homooligomer (via its N-terminal domain) (By similarity). Interacts with BRDT (PubMed:22570411). Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimum of six contiguous repeats. Interacts with ATXN2; the interaction is RNA-dependent. Interacts with MATR3. Interacts with UBQLN2. Interacts with HNRNPA2B1 (By similarity). Interacts with ZNF106 (PubMed:28072389). Interacts with CNOT7/CAF1 (By similarity). Interacts with CRY2 (PubMed:27123980). Interacts with PPIA/CYPA; the interaction is dependent on RNA-binding activity of TARDBP and PPIase activity of PPIA/CYPA (PubMed:25678563). Acetylation of PPIA/CYPA at 'Lys-125' favors the interaction of TARDBP with PPIA/CYPA (By similarity). Nucleus Cytoplasm Cytoplasm, Stress granule Mitochondrion Note=Continuously travels in and out of the nucleus. Localizes to stress granules in response to oxidative stress. A small subset localizes in mitochondria. The RRM domains can bind to both DNA and RNA. Hyperphosphorylated. Ubiquitinated. TARDBP depletion leads to atrophy of spinal motor neurons. Affects motor axon, neuromuscular junction and skeletal muscle. RNA polymerase II distal enhancer sequence-specific DNA binding negative regulation of protein phosphorylation nucleic acid binding DNA binding double-stranded DNA binding RNA binding mRNA 3'-UTR binding protein binding nucleus nucleoplasm cytoplasm mRNA processing RNA splicing gene expression cytoplasmic stress granule negative regulation of gene expression regulation of protein stability positive regulation of protein import into nucleus regulation of circadian rhythm identical protein binding regulation of apoptotic process sequence-specific DNA binding negative regulation by host of viral transcription rhythmic process regulation of cell cycle 3'-UTR-mediated mRNA stabilization nuclear inner membrane organization pre-mRNA intronic binding sequence-specific double-stranded DNA binding ribonucleoprotein complex uc008vvg.1 uc008vvg.2 uc008vvg.3 
ENSMUST00000084129.9 Mad2l2 ENSMUST00000084129.9 MAD2 mitotic arrest deficient-like 2, transcript variant 2 (from RefSeq NM_001305420.1) ENSMUST00000084129.1 ENSMUST00000084129.2 ENSMUST00000084129.3 ENSMUST00000084129.4 ENSMUST00000084129.5 ENSMUST00000084129.6 ENSMUST00000084129.7 ENSMUST00000084129.8 MD2L2_MOUSE Mad2b NM_001305420 Q3TMY6 Q91VP1 Q9D752 Rev7 uc008vub.1 uc008vub.2 uc008vub.3 uc008vub.4 Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation. Homooligomer (By similarity). Heterodimer with REV3L (By similarity). This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context (By similarity). Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta (By similarity). Component of the shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and MAD2L2/REV7. Within the complex, SHLD2 forms a scaffold which interacts with a SHLD3-MAD2L2 subcomplex via its N-terminus, and with SHLD1 via its C- terminus (By similarity). Interacts with REV1 (PubMed:14657033). Interacts with ADAM9 (By similarity). Interacts with CHAMP1 (By similarity). Interacts with FZR1 (in complex with the anaphase promoting complex APC) (By similarity). May interact with CDC20 (By similarity). Interacts with RAN (By similarity). Interacts with ELK1; the interaction is direct and recruits MAD2L2 to ELK1-specific promoters (By similarity). May interact with the JNK kinases MAPK8 and/or MAPK9 to stimulate ELK1 phosphorylation and transcriptional activity upon DNA damage (By similarity). Interacts with TCF7L2; prevents its binding to promoters and negatively modulates its transcriptional activity (By similarity). Interacts with YY1AP1 (By similarity). Interacts with PRCC; the interaction is direct (By similarity). Interacts with POGZ (By similarity). Nucleus Cytoplasm, cytoskeleton, spindle Cytoplasm Chromosome Note=Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding regulation of cell growth nucleus anaphase-promoting complex chromosome nucleolus cytoplasm spindle cytosol cytoskeleton DNA repair double-strand break repair cellular response to DNA damage stimulus actin filament organization cell cycle JUN kinase binding negative regulation of epithelial to mesenchymal transition negative regulation of transcription by competitive promoter binding zeta DNA polymerase complex positive regulation of peptidyl-serine phosphorylation negative regulation of protein catabolic process DNA damage response, signal transduction resulting in transcription negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of isotype switching positive regulation of transcription, DNA-templated cell division negative regulation of canonical Wnt signaling pathway negative regulation of ubiquitin protein ligase activity negative regulation of double-strand break repair via homologous recombination negative regulation of cell-cell adhesion mediated by cadherin negative regulation of transcription regulatory region DNA binding positive regulation of double-strand break repair via nonhomologous end joining uc008vub.1 uc008vub.2 uc008vub.3 uc008vub.4 
ENSMUST00000084141.6 Zfp820 ENSMUST00000084141.6 zinc finger protein 820 (from RefSeq NM_029281.2) E9Q5G8 E9Q5G8_MOUSE ENSMUST00000084141.1 ENSMUST00000084141.2 ENSMUST00000084141.3 ENSMUST00000084141.4 ENSMUST00000084141.5 NM_029281 Zfp820 uc008ari.1 uc008ari.2 uc008ari.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008ari.1 uc008ari.2 uc008ari.3 
ENSMUST00000084149.10 Zfp991 ENSMUST00000084149.10 zinc finger protein 991 (from RefSeq NM_001083918.1) ENSMUST00000084149.1 ENSMUST00000084149.2 ENSMUST00000084149.3 ENSMUST00000084149.4 ENSMUST00000084149.5 ENSMUST00000084149.6 ENSMUST00000084149.7 ENSMUST00000084149.8 ENSMUST00000084149.9 Gm13139 NM_001083918 OTTMUSG00000010657 Q8R1N3 Q8R1N3_MOUSE Zfp991 uc033ign.1 uc033ign.2 uc033ign.3 uc033ign.4 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc033ign.1 uc033ign.2 uc033ign.3 uc033ign.4 
ENSMUST00000084203.11 Plekhm2 ENSMUST00000084203.11 pleckstrin homology domain containing, family M (with RUN domain) member 2, transcript variant 1 (from RefSeq NM_001033150.2) ENSMUST00000084203.1 ENSMUST00000084203.10 ENSMUST00000084203.2 ENSMUST00000084203.3 ENSMUST00000084203.4 ENSMUST00000084203.5 ENSMUST00000084203.6 ENSMUST00000084203.7 ENSMUST00000084203.8 ENSMUST00000084203.9 NM_001033150 Plekhm2 Z4YJW6 Z4YJW6_MOUSE uc008vpa.1 uc008vpa.2 uc008vpa.3 uc008vpa.4 Golgi organization endosome membrane kinesin binding lysosome localization regulation of protein localization positive regulation of membrane tubulation uc008vpa.1 uc008vpa.2 uc008vpa.3 uc008vpa.4 
ENSMUST00000084207.12 Arhgef10 ENSMUST00000084207.12 Rho guanine nucleotide exchange factor 10, transcript variant 1 (from RefSeq NM_172751.3) ARHGA_MOUSE ENSMUST00000084207.1 ENSMUST00000084207.10 ENSMUST00000084207.11 ENSMUST00000084207.2 ENSMUST00000084207.3 ENSMUST00000084207.4 ENSMUST00000084207.5 ENSMUST00000084207.6 ENSMUST00000084207.7 ENSMUST00000084207.8 ENSMUST00000084207.9 Kiaa0294 NM_172751 Q5DU38 Q80VH8 Q8BW76 Q8C033 Q922S7 uc009kzg.1 uc009kzg.2 uc009kzg.3 May play a role in developmental myelination of peripheral nerves. Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q8C033-1; Sequence=Displayed; Name=2; IsoId=Q8C033-2; Sequence=VSP_010707; Ubiquitously expressed. Found in the neuroepithelium of the meninges at 8.5 dpc, and in the roof plate of the rhombencephalon at 9.5 dpc. In 12.5 dpc embryos, it is ubiquitously expressed, with a pronounced expression in the neuroepithelium of brain vesicles, the neural tube, the ganglia and the neural layer of the retina. Methylated at Gln-1314 by N6AMT1. Sequence=AAH59212.1; Type=Erroneous initiation; Evidence=; Sequence=AAH66074.1; Type=Erroneous initiation; Evidence=; Sequence=BAC27875.1; Type=Erroneous initiation; Evidence=; Sequence=BAD90400.1; Type=Erroneous initiation; Evidence=; guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity centrosome cytosol kinesin binding myelination in peripheral nervous system actin cytoskeleton organization regulation of Rho protein signal transduction centrosome duplication positive regulation of stress fiber assembly mitotic spindle assembly activation of GTPase activity uc009kzg.1 uc009kzg.2 uc009kzg.3 
ENSMUST00000084215.12 Eif4g3 ENSMUST00000084215.12 eukaryotic translation initiation factor 4 gamma, 3, transcript variant 6 (from RefSeq NM_001369130.1) A2AMI2 A2AMI2_MOUSE ENSMUST00000084215.1 ENSMUST00000084215.10 ENSMUST00000084215.11 ENSMUST00000084215.2 ENSMUST00000084215.3 ENSMUST00000084215.4 ENSMUST00000084215.5 ENSMUST00000084215.6 ENSMUST00000084215.7 ENSMUST00000084215.8 ENSMUST00000084215.9 Eif4g3 NM_001369130 uc008vkd.1 uc008vkd.2 uc008vkd.3 uc008vkd.4 Belongs to the eukaryotic initiation factor 4G family. RNA cap binding RNA binding translation initiation factor activity translational initiation uc008vkd.1 uc008vkd.2 uc008vkd.3 uc008vkd.4 
ENSMUST00000084238.5 Zdhhc18 ENSMUST00000084238.5 zinc finger, DHHC domain containing 18 (from RefSeq NM_001017968.2) A2A9F0 ENSMUST00000084238.1 ENSMUST00000084238.2 ENSMUST00000084238.3 ENSMUST00000084238.4 NM_001017968 Q5Y5T2 ZDH18_MOUSE Zdhhc18 uc008vde.1 uc008vde.2 uc008vde.3 Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:15603741, PubMed:35438208). Palmitoylates HRAS and LCK (PubMed:15603741). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein- coupled receptor signaling (By similarity). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Golgi apparatus membrane ; Multi-pass membrane protein Ubiquitously expressed. The DHHC domain is required for palmitoyltransferase activity. Mice were born at the expected Mendelian ratio, develop normally and are fertile (PubMed:35438208). Mice display increased resistance to infection by DNA viruses due to increased activation of the cGAS-STING pathway (PubMed:35438208). Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. endoplasmic reticulum Golgi apparatus protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity cellular protein localization uc008vde.1 uc008vde.2 uc008vde.3 
ENSMUST00000084241.12 Wasf2 ENSMUST00000084241.12 WASP family, member 2, transcript variant 1 (from RefSeq NM_153423.7) ENSMUST00000084241.1 ENSMUST00000084241.10 ENSMUST00000084241.11 ENSMUST00000084241.2 ENSMUST00000084241.3 ENSMUST00000084241.4 ENSMUST00000084241.5 ENSMUST00000084241.6 ENSMUST00000084241.7 ENSMUST00000084241.8 ENSMUST00000084241.9 NM_153423 Q8BH43 WASF2_MOUSE Wasf2 Wave2 uc008vcf.1 uc008vcf.2 uc008vcf.3 Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2. Directly interacts with BRK1. Interacts with human cytomegalovirus protein UL135. Interacts with FNBP1L (via the SH3 domain). Q8BH43; Q8CBW3: Abi1; NbExp=2; IntAct=EBI-643162, EBI-375511; Q8BH43; Q8CHG3: Gcc2; NbExp=6; IntAct=EBI-643162, EBI-643470; Q8BH43; Q3URD3-4: Slmap; NbExp=3; IntAct=EBI-643162, EBI-3294998; Q8BH43; Q8CG48: Smc2; NbExp=4; IntAct=EBI-643162, EBI-643436; Cytoplasm, cytoskeleton Cell projection, lamellipodium Basolateral cell membrane Note=At the interface between the lamellipodial actin meshwork and the membrane. Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain (By similarity). Belongs to the SCAR/WAVE family. angiogenesis ameboidal-type cell migration ruffle actin binding protein binding cytoplasm early endosome cytoskeleton cell-cell junction endocytosis positive regulation of lamellipodium assembly Rac protein signal transduction SH3 domain binding lamellipodium lamellipodium assembly actin cytoskeleton organization actin filament-based movement SCAR complex macromolecular complex megakaryocyte development cell projection synapse protein kinase A binding negative regulation of stress fiber assembly lamellipodium morphogenesis postsynaptic actin cytoskeleton organization uc008vcf.1 uc008vcf.2 uc008vcf.3 
ENSMUST00000084253.10 Epb41 ENSMUST00000084253.10 erythrocyte membrane protein band 4.1, transcript variant 2 (from RefSeq NM_001128606.1) A2A843 ENSMUST00000084253.1 ENSMUST00000084253.2 ENSMUST00000084253.3 ENSMUST00000084253.4 ENSMUST00000084253.5 ENSMUST00000084253.6 ENSMUST00000084253.7 ENSMUST00000084253.8 ENSMUST00000084253.9 EPB41_MOUSE Epb4.1 Epb41 Kiaa4056 NM_001128606 P48193 Q5DTQ8 Q68FF1 Q6NVF5 uc008val.1 uc008val.2 uc008val.3 uc008val.4 uc008val.5 uc008val.6 Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. Binds with a high affinity to glycophorin and with lower affinity to band III protein. Associates with the nuclear mitotic apparatus. Binds calmodulin, CENPJ and DLG1. Also found to associate with contractile apparatus and tight junctions. Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes anaphase-specific localization of NUMA1 in symmetrically dividing cells. Interacts with ATP2B1; regulates small intestinal calcium absorption through regulation of membrane expression of ATP2B1 (PubMed:23460639). Nucleus Cytoplasm, cytoskeleton Cytoplasm, cell cortex Event=Alternative splicing; Named isoforms=2; Comment=A number of isoforms are produced.; Name=1; IsoId=P48193-1; Sequence=Displayed; Name=2; IsoId=P48193-2; Sequence=VSP_012874; O-glycosylated; contains N-acetylglucosamine side chains in the C- terminal domain. Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions. Phosphorylation on Tyr-654 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex. Sequence=BAD90280.1; Type=Erroneous initiation; Evidence=; actin binding structural molecule activity protein binding calmodulin binding 1-phosphatidylinositol binding nucleus cytoplasm cytosol cytoskeleton plasma membrane cell cortex cell cycle protein C-terminus binding cytoskeletal protein binding regulation of cell shape cytoplasmic side of plasma membrane postsynaptic density actin cytoskeleton membrane basolateral plasma membrane actin cytoskeleton organization cell junction spectrin binding cortical cytoskeleton cortical actin cytoskeleton organization actomyosin structure organization positive regulation of protein binding macromolecular complex protein N-terminus binding phosphoprotein binding cell division regulation of calcium ion transport macromolecular complex assembly cell cortex region regulation of intestinal absorption positive regulation of protein localization to cell cortex uc008val.1 uc008val.2 uc008val.3 uc008val.4 uc008val.5 uc008val.6 
ENSMUST00000084263.6 Spocd1 ENSMUST00000084263.6 Spocd1 (from geneSymbol) A0A7N9T6T7 A0A7N9T6T7_MOUSE ENSMUST00000084263.1 ENSMUST00000084263.2 ENSMUST00000084263.3 ENSMUST00000084263.4 ENSMUST00000084263.5 Spocd1 uc290qfg.1 uc290qfg.2 uc290qfg.1 uc290qfg.2 
ENSMUST00000084289.5 Ago4 ENSMUST00000084289.5 argonaute RISC catalytic subunit 4 (from RefSeq NM_153177.3) AGO4_MOUSE ENSMUST00000084289.1 ENSMUST00000084289.2 ENSMUST00000084289.3 ENSMUST00000084289.4 Eif2c4 Kiaa1567 NM_153177 Q4VBD7 Q6ZPM6 Q8BTF4 Q8CJF8 uc008utk.1 uc008utk.2 uc008utk.3 uc008utk.4 uc008utk.5 Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36. Cytoplasm, P-body Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CJF8-1; Sequence=Displayed; Name=2; IsoId=Q8CJF8-2; Sequence=VSP_036487; Ubiquitinated on surface-exposed lysines by a SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 during target- directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). Ubiquitination by the SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 leads to its subsequent degradation, thereby exposing miRNAs for degradation. ZSWIM8 recognizes and binds AGO4 when it is engaged with a TDMD target. Belongs to the argonaute family. Ago subfamily. Sequence=BAC26738.1; Type=Erroneous initiation; Evidence=; Sequence=BAC98205.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; P-body nucleic acid binding RNA binding double-stranded RNA binding single-stranded RNA binding nucleus nucleoplasm cytoplasm cytosol mRNA catabolic process regulation of translation synaptonemal complex assembly male meiosis male gonad development RNA secondary structure unwinding miRNA metabolic process RISC complex nuclear body regulation of cell morphogenesis gene silencing by RNA pre-miRNA processing production of miRNAs involved in gene silencing by miRNA miRNA binding miRNA mediated inhibition of translation miRNA loading onto RISC involved in gene silencing by miRNA negative regulation of apoptotic process RISC-loading complex uc008utk.1 uc008utk.2 uc008utk.3 uc008utk.4 uc008utk.5 
ENSMUST00000084296.10 Cdca8 ENSMUST00000084296.10 cell division cycle associated 8 (from RefSeq NM_026560.4) B1ARX0 B1ARX1 BOREA_MOUSE ENSMUST00000084296.1 ENSMUST00000084296.2 ENSMUST00000084296.3 ENSMUST00000084296.4 ENSMUST00000084296.5 ENSMUST00000084296.6 ENSMUST00000084296.7 ENSMUST00000084296.8 ENSMUST00000084296.9 NM_026560 Q6NVD3 Q8BHB1 Q8BHQ5 Q8BHQ9 Q8BHX3 Q9CRN4 Q9CS02 Q9CTF4 uc008urj.1 uc008urj.2 uc008urj.3 Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment (By similarity). May form homooligomers and homodimers. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and BIRC5 (By similarity). Interacts with SENP3, UBE2I and RANBP2. Interacts (phosphorylated) with SGO1 and SGO2; the association is dependent on CDK1 (By similarity). Nucleus, nucleolus Cytoplasm Chromosome, centromere Cytoplasm, cytoskeleton, spindle Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BHX3-1; Sequence=Displayed; Name=2; IsoId=Q8BHX3-2; Sequence=VSP_019924; Name=3; IsoId=Q8BHX3-3; Sequence=VSP_019922, VSP_019923; The C-terminal region (aa 216-289) represents the dimerization motif. Phosphorylated by TTK, essentially at Thr-94. Phosphorylation (probably by CDK1) promotes targeting of the CPC to centromeric DNA. Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3 (By similarity). Citrullinated by PADI4. Belongs to the borealin family. mitotic sister chromatid segregation chromosome, centromeric region protein binding nucleus chromosome nucleolus cytoplasm spindle cytoskeleton cell cycle mitotic metaphase plate congression chromocenter midbody chromosome passenger complex macromolecular complex intercellular bridge spindle midzone chromosome organization cell division uc008urj.1 uc008urj.2 uc008urj.3 
ENSMUST00000084299.6 Akirin2 ENSMUST00000084299.6 akirin 2 (from RefSeq NM_001007589.3) AKIR2_MOUSE Akirin2 B1AXD8 ENSMUST00000084299.1 ENSMUST00000084299.2 ENSMUST00000084299.3 ENSMUST00000084299.4 ENSMUST00000084299.5 NM_001007589 Q641L8 Q9DAH4 uc008sga.1 uc008sga.2 uc008sga.3 Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:25107474, PubMed:26041538, PubMed:27871306, PubMed:30116001, PubMed:30801883). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (PubMed:18066067, PubMed:25107474). Also involved in adaptive immunity by promoting B-cell activation (PubMed:26041538). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (PubMed:27871306). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (PubMed:30801883). Also plays a role in facilitating interdigital tissue regression during limb development (PubMed:30116001). Homodimer (By similarity). Interacts with IPO9; the interaction is direct (By similarity). Associates with 20S and 26S proteasomes (By similarity). Interacts with SMARCD1; promoting SWI/SNF complex recruitment (PubMed:25107474). Interacts with NFKBIZ (PubMed:25107474). Interacts with YWHAB (By similarity). B1AXD8; Q9EST8: Nfkbiz; NbExp=3; IntAct=EBI-10107866, EBI-10107924; B1AXD8; Q61466: Smarcd1; NbExp=2; IntAct=EBI-10107866, EBI-371529; B1AXD8; Q9BYH8: NFKBIZ; Xeno; NbExp=3; IntAct=EBI-10107866, EBI-3939694; Nucleus toplasm Membrane Note=Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions. Expressed throughout cortical development: present throughout the cortical wall at all of these ages, with strong expression in the early ventricular zone and the embryonic preplate/cortical plate (PubMed:27871306). Expressed in the developing limb: expressed in the forelimb bud and somites at 10.5 dpc, as well as in the apical ectodermal ridge (AER) (PubMed:30116001). Ubiquitously expressed throughout the embryonic forelimb at 10.5 dpc: expressed in the dermomyotome and sclerotome divisions of the somite (at protein level) (PubMed:30801883). Mice are embryonic lethal (PubMed:18066067). Null mutant embryos could not be detected even on embryonic day 9.5 (PubMed:18066067). Conditional deletion in macrophages impairs proinflammatory cytokine production in response to Listeria infection and clearance of infecting bacteria (PubMed:25107474). Conditional deletion in B-cells causes a decrease in the splenic B-cell numbers, leading to severe proliferation and activation defects in B-cells (PubMed:26041538). The B-cell viability is also impaired, leading to decreased immune responses to T-dependent and T-independent antigens (PubMed:26041538). Conditional deletion in the cortex leads to severe microcephaly: mice do not survive past birth and exhibit extreme microcephaly, with little dorsal telencephalic tissue and no recognizable cortex (PubMed:27871306). Defects in the cortex are caused to massive cell death of early cortical progenitors (PubMed:27871306). Conditional deletion in somitic muscle precursor cells results in neonatal lethality: mutant embryos show a complete lack of forelimb, intercostal and diaphragm muscles due to extensive apoptosis and loss of myoblasts (PubMed:30801883). Embryos lacking Akirin2 in somitic muscle precursor cells also display severe skeletal defects, including craniofacial abnormalities, disrupted ossification and rib fusions (PubMed:30801883). Conditional deletion in limb bud epithelium leads to soft-tissue syndactyly, characterized by a loss of interdigital cell death and an increase in cell proliferation, resulting in retention of the interdigital web (PubMed:30116001). 'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal. Belongs to the akirin family. Sequence=BAB24265.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter immune system process protein binding nucleus nucleoplasm multicellular organism development positive regulation of cell proliferation embryo development ending in birth or egg hatching negative regulation of gene expression positive regulation of endopeptidase activity transcriptional repressor complex enzyme binding response to lipopolysaccharide positive regulation of interleukin-6 production innate immune response negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc008sga.1 uc008sga.2 uc008sga.3 
ENSMUST00000084313.5 Or10ak12 ENSMUST00000084313.5 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt F7D7G9) BC147439 ENSMUST00000084313.1 ENSMUST00000084313.2 ENSMUST00000084313.3 ENSMUST00000084313.4 F7D7G9 F7D7G9_MOUSE Olfr1335 Or10ak12 uc008ukw.1 uc008ukw.2 uc008ukw.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008ukw.1 uc008ukw.2 uc008ukw.3 
ENSMUST00000084315.4 Or10ak14 ENSMUST00000084315.4 olfactory receptor family 10 subfamily AK member 14 (from RefSeq NM_207152.2) A2ACY7 A2ACY7_MOUSE ENSMUST00000084315.1 ENSMUST00000084315.2 ENSMUST00000084315.3 NM_207152 Olfr1329 Olfr1338 Or10ak14 uc008uku.1 uc008uku.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC130245.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008uku.1 uc008uku.2 
ENSMUST00000084342.6 Cyp4a32 ENSMUST00000084342.6 cytochrome P450, family 4, subfamily a, polypeptide 32, transcript variant 2 (from RefSeq NM_001425042.1) A2A8T1 A2A8T1_MOUSE Cyp4a32 ENSMUST00000084342.1 ENSMUST00000084342.2 ENSMUST00000084342.3 ENSMUST00000084342.4 ENSMUST00000084342.5 NM_001425042 uc290ovi.1 uc290ovi.2 Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm arachidonic acid monooxygenase activity arachidonic acid epoxygenase activity membrane integral component of membrane apical plasma membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen alkane 1-monooxygenase activity heme binding leukotriene B4 catabolic process intracellular membrane-bounded organelle metal ion binding leukotriene-B4 20-monooxygenase activity oxidation-reduction process uc290ovi.1 uc290ovi.2 
ENSMUST00000084343.4 Cyp4a12a ENSMUST00000084343.4 cytochrome P450, family 4, subfamily a, polypeptide 12a (from RefSeq NM_177406.3) A2A973 CP4CA_MOUSE Cyp4a12 Cyp4a12a ENSMUST00000084343.1 ENSMUST00000084343.2 ENSMUST00000084343.3 NM_177406 Q3UNE4 Q6P931 Q8N7N3 Q91WL5 uc008uer.1 uc008uer.2 A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:17112342). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:17112342). Catalyzes predominantly the oxidation of the terminal carbon (omega- oxidation) of saturated and unsaturated fatty acids (PubMed:17112342). May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney (PubMed:17112342). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20- hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure. Further catalyzes successive omega-oxidations of 20-HETE to the corresponding dicarboxylic acid, and may contribute to the degradation of PUFA by chain shortening (PubMed:17112342). Acts as an omega-hydroxylase and epoxidase toward (5Z,8Z,11Z,14Z,17Z)- eicosapentaenoc acid (EPA). Catalyzes stereoselective epoxidation of the last double bond of EPA, displaying a strong preference for the (R,S) stereoisomer (PubMed:17112342). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:17112342). Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence=; Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39751, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76628; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39752; Evidence=; Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38947, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:36204, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38948; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39759, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76627; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39760; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39755, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76624; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39756; Evidence=; Reaction=20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-(5Z,8Z,11Z,14Z)- eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39767, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76624, ChEBI:CHEBI:76645; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39768; Evidence=; Reaction=20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39771, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76645, ChEBI:CHEBI:76647; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39772; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)- eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39787, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76636; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39788; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)- eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39791, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76639; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39792; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)- eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39783, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76635; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39784; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)- eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39779, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76634; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39780; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Activated by cytochrome b5. The Vmax almost doubles in the presence of cytochrome b5. Kinetic parameters: KM=16 uM for dodecanoic acid ; KM=25 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (without cytochrome b5) ; KM=34 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (with cytochrome b5) ; KM=29 uM for (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoic acid (without cytochrome b5) ; KM=33 uM for (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoic acid (with cytochrome b5) ; Vmax=76 nmol/min/nmol enzyme toward dodecanoic acid ; Vmax=8 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (without cytochrome b5) ; Vmax=16 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (with cytochrome b5) ; Vmax=14 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z,17Z)- eicosapentaenoic acid (without cytochrome b5) ; Vmax=29 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z,17Z)- eicosapentaenoic acid (with cytochrome b5) ; Lipid metabolism; fatty acid metabolism. Endoplasmic reticulum membrane ; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein. Gender- and strain-specific expression in kidney (at protein level). Predominantly expressed in males, the expression among strains decreasing in the following order: NMRI > FVB/N > 129 Sv/J > Balb/c > C57BL/6. Expressed in renal arterioles. Up-regulated by 5alpha-dihydrotestosterone. Belongs to the cytochrome P450 family. Sequence=BAE25803.1; Type=Frameshift; Evidence=; monooxygenase activity iron ion binding extracellular space endoplasmic reticulum endoplasmic reticulum membrane fatty acid metabolic process membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen alkane 1-monooxygenase activity heme binding organelle membrane intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc008uer.1 uc008uer.2 
ENSMUST00000084368.12 Kif19a ENSMUST00000084368.12 kinesin family member 19A (from RefSeq NM_001102615.2) A7DTH0 ENSMUST00000084368.1 ENSMUST00000084368.10 ENSMUST00000084368.11 ENSMUST00000084368.2 ENSMUST00000084368.3 ENSMUST00000084368.4 ENSMUST00000084368.5 ENSMUST00000084368.6 ENSMUST00000084368.7 ENSMUST00000084368.8 ENSMUST00000084368.9 KIF19_MOUSE Kif19 NM_001102615 Q99PT9 uc007mfq.1 uc007mfq.2 Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips. Cytoplasm, cytoskeleton Cell projection, cilium Note=Localizes to cilia tips. Strongly expressed in the oviduct and trachea. Expressed in testis, lung, ovary and brain. Mice show growth retardation, higher mortality (4 weeks after birth) and display hydrocephalus as well as female infertility. Female infertility is probably caused by fallopian tube obstruction. Phenotypes are due to abnormally elongated cilia that cannot generate proper fluid flow. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding microtubule motor activity ATP binding cytoplasm cytoskeleton kinesin complex microtubule cilium axoneme microtubule-based movement microtubule binding ATP-dependent microtubule motor activity, plus-end-directed ATPase activity cell projection axonemal microtubule depolymerization plus-end specific microtubule depolymerization uc007mfq.1 uc007mfq.2 
ENSMUST00000084382.6 Insl5 ENSMUST00000084382.6 insulin-like 5, transcript variant 2 (from RefSeq NM_011831.3) ENSMUST00000084382.1 ENSMUST00000084382.2 ENSMUST00000084382.3 ENSMUST00000084382.4 ENSMUST00000084382.5 INSL5_MOUSE NM_011831 Q9WUG6 Rif Rif2 Zins3 uc008txa.1 uc008txa.2 uc008txa.3 uc008txa.4 May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity). Heterodimer of a B chain and an A chain linked by two disulfide bonds. Secreted Highest expression in colon with lower levels in thymus. Minimal levels in testis. Belongs to the insulin family. Sequence=AAF09093.1; Type=Erroneous initiation; Evidence=; G-protein coupled receptor binding hormone activity extracellular region signal transduction positive regulation of feeding behavior uc008txa.1 uc008txa.2 uc008txa.3 uc008txa.4 
ENSMUST00000084412.6 Ifitm10 ENSMUST00000084412.6 interferon induced transmembrane protein 10, transcript variant 7 (from RefSeq NM_001419318.1) ENSMUST00000084412.1 ENSMUST00000084412.2 ENSMUST00000084412.3 ENSMUST00000084412.4 ENSMUST00000084412.5 IFM10_MOUSE NM_001419318 Q810P6 Q8BR26 uc009kmu.1 uc009kmu.2 uc009kmu.3 uc009kmu.4 Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BR26-1; Sequence=Displayed; Name=2; IsoId=Q8BR26-2; Sequence=VSP_041596; Name=3; IsoId=Q8BR26-3; Sequence=VSP_041596, VSP_033398; Belongs to the CD225/Dispanin family. molecular_function plasma membrane biological_process membrane integral component of membrane uc009kmu.1 uc009kmu.2 uc009kmu.3 uc009kmu.4 
ENSMUST00000084418.4 Mob2 ENSMUST00000084418.4 MOB kinase activator 2, transcript variant 1 (from RefSeq NM_028308.2) ENSMUST00000084418.1 ENSMUST00000084418.2 ENSMUST00000084418.3 MOB2_MOUSE Mmh NM_028308 Q3UXL5 Q8VI63 Q9CZJ5 uc009kmk.1 uc009kmk.2 uc009kmk.3 Stimulates the autophosphorylation and kinase activity of STK38 and STK38L. Binds STK38 and STK38L. Nucleus Cytoplasm, perinuclear region Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VI63-1; Sequence=Displayed; Name=2; IsoId=Q8VI63-2; Sequence=VSP_012300; Phosphorylated. Belongs to the MOB1/phocein family. positive regulation of protein phosphorylation molecular_function nucleus nucleolus cytoplasm cytosol positive regulation of neuron projection development actin cytoskeleton organization neuron projection terminus metal ion binding perinuclear region of cytoplasm uc009kmk.1 uc009kmk.2 uc009kmk.3 
ENSMUST00000084434.11 Rplp2 ENSMUST00000084434.11 ribosomal protein lateral stalk subunit P2, transcript variant 1 (from RefSeq NM_026020.7) ENSMUST00000084434.1 ENSMUST00000084434.10 ENSMUST00000084434.2 ENSMUST00000084434.3 ENSMUST00000084434.4 ENSMUST00000084434.5 ENSMUST00000084434.6 ENSMUST00000084434.7 ENSMUST00000084434.8 ENSMUST00000084434.9 NM_026020 P99027 Q3TKY3 Q9CQ99 Q9CZJ8 RLA2_MOUSE uc009klf.1 uc009klf.2 uc009klf.3 Plays an important role in the elongation step of protein synthesis. Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein P1/P2 family. structural constituent of ribosome ribosome translational elongation cytosolic large ribosomal subunit synapse uc009klf.1 uc009klf.2 uc009klf.3 
ENSMUST00000084456.6 Or13a20 ENSMUST00000084456.6 olfactory receptor family 13 subfamily A member 20 (from RefSeq NM_146960.2) ENSMUST00000084456.1 ENSMUST00000084456.2 ENSMUST00000084456.3 ENSMUST00000084456.4 ENSMUST00000084456.5 NM_146960 Olfr53 Or13a20 Q8VGL8 Q8VGL8_MOUSE uc009khy.1 uc009khy.2 uc009khy.3 uc009khy.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: DR065587.1, CB172928.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009khy.1 uc009khy.2 uc009khy.3 uc009khy.4 
ENSMUST00000084460.7 Scart1 ENSMUST00000084460.7 scavenger receptor family member expressed on T cells 1 (from RefSeq NM_172909.4) Cd163l1 ENSMUST00000084460.1 ENSMUST00000084460.2 ENSMUST00000084460.3 ENSMUST00000084460.4 ENSMUST00000084460.5 ENSMUST00000084460.6 NM_172909 Q8CGY7 Q8CGY7_MOUSE Scart1 uc009khk.1 uc009khk.2 Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function scavenger receptor activity cytoplasm plasma membrane brush border endocytosis biological_process external side of plasma membrane membrane integral component of membrane uc009khk.1 uc009khk.2 
ENSMUST00000084474.6 Frmd3 ENSMUST00000084474.6 FERM domain containing 3, transcript variant 1 (from RefSeq NM_172869.5) A2BEJ6 ENSMUST00000084474.1 ENSMUST00000084474.2 ENSMUST00000084474.3 ENSMUST00000084474.4 ENSMUST00000084474.5 FRMD3_MOUSE NM_172869 Q3UF23 Q5SPU0 Q5SPU1 Q8BHD4 Q8C045 uc008tjg.1 uc008tjg.2 uc008tjg.3 uc008tjg.4 Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BHD4-1; Sequence=Displayed; Name=2; IsoId=Q8BHD4-2; Sequence=VSP_031168; Name=3; IsoId=Q8BHD4-3; Sequence=VSP_031169, VSP_031170; cytoskeleton cytoskeletal protein binding membrane integral component of membrane actomyosin structure organization uc008tjg.1 uc008tjg.2 uc008tjg.3 uc008tjg.4 
ENSMUST00000084475.4 Msantd5f1 ENSMUST00000084475.4 Myb/SANT DNA binding domain containing 5 family member 1 (from RefSeq NM_001081644.1) ENSMUST00000084475.1 ENSMUST00000084475.2 ENSMUST00000084475.3 Gm428 Msantd5f1 NM_001081644 Q3UTE2 Q3UTE2_MOUSE uc033ida.1 uc033ida.2 uc033ida.3 uc033ida.4 This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is supported by alignment of transcripts. [provided by RefSeq, Apr 2013]. ##Evidence-Data-START## Transcript exon combination :: AK139501.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END## molecular_function cellular_component biological_process uc033ida.1 uc033ida.2 uc033ida.3 uc033ida.4 
ENSMUST00000084479.5 Msantd5f3 ENSMUST00000084479.5 Myb/SANT DNA binding domain containing 5 family member 3 (from RefSeq NM_001277512.1) ENSMUST00000084479.1 ENSMUST00000084479.2 ENSMUST00000084479.3 ENSMUST00000084479.4 F2Z478 F2Z478_MOUSE Gm11238 Msantd5f3 NM_001277512 uc290nhp.1 uc290nhp.2 uc290nhp.3 This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is supported by transcripts and inferred from alignment of paralogous transcripts. [provided by RefSeq, Apr 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments and paralogous data. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## molecular_function cellular_component biological_process uc290nhp.1 uc290nhp.2 uc290nhp.3 
ENSMUST00000084480.6 Msantd5f6 ENSMUST00000084480.6 Myb/SANT DNA binding domain containing 5 family member 6 (from RefSeq NM_001013393.1) ENSMUST00000084480.1 ENSMUST00000084480.2 ENSMUST00000084480.3 ENSMUST00000084480.4 ENSMUST00000084480.5 Gm11487 Msantd5f6 NM_001013393 OTTMUSG00000001246 Q5RIS0 Q5RIS0_MOUSE RP23-289L21.1-001 uc008tio.1 uc008tio.2 This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is inferred from alignment of paralogous transcripts. [provided by RefSeq, Apr 2013]. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END## molecular_function cellular_component biological_process uc008tio.1 uc008tio.2 
ENSMUST00000084488.5 Dock1 ENSMUST00000084488.5 dedicator of cytokinesis 1 (from RefSeq NM_001033420.2) DOCK1_MOUSE ENSMUST00000084488.1 ENSMUST00000084488.2 ENSMUST00000084488.3 ENSMUST00000084488.4 NM_001033420 Q3URT8 Q3UY80 Q4QQL8 Q6PD14 Q8BUR4 Q8BVC9 Q91Z55 Q922V1 uc009kdv.1 uc009kdv.2 uc009kdv.3 Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DOCKER domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 (By similarity). Interacts with ELMO1 and ADGRB1 (PubMed:17960134). Identified in a complex with AUTS2 and ELMO2 (PubMed:25533347). Q8BUR4; Q8BPU7-1: Elmo1; NbExp=13; IntAct=EBI-646023, EBI-644162; Q8BUR4; Q8BYZ7: Elmo3; NbExp=4; IntAct=EBI-646023, EBI-646035; Q8BUR4; Q8C0C0: Zhx2; NbExp=3; IntAct=EBI-646023, EBI-646042; Cytoplasm Membrane Note=Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BUR4-1; Sequence=Displayed; Name=2; IsoId=Q8BUR4-2; Sequence=VSP_022205, VSP_022206; The DOCKER domain is necessary and sufficient for the GEF activity. Belongs to the DOCK family. hematopoietic progenitor cell differentiation guanyl-nucleotide exchange factor activity GTPase activator activity protein binding nucleus cytoplasm cytosol phagocytosis apoptotic process small GTPase mediated signal transduction positive regulation of epithelial cell migration membrane cell migration nuclear speck SH3 domain binding guanyl-nucleotide exchange factor complex positive regulation of GTPase activity positive regulation of substrate adhesion-dependent cell spreading uc009kdv.1 uc009kdv.2 uc009kdv.3 
ENSMUST00000084489.3 Gm11232 ENSMUST00000084489.3 Gm11232 (from geneSymbol) ENSMUST00000084489.1 ENSMUST00000084489.2 Gm11232 Q5SPI8 Q5SPI8_MOUSE uc290ngs.1 uc290ngs.2 molecular_function cellular_component biological_process uc290ngs.1 uc290ngs.2 
ENSMUST00000084497.12 Abraxas2 ENSMUST00000084497.12 BRISC complex subunit (from RefSeq NM_198017.3) Abraxas2 ENSMUST00000084497.1 ENSMUST00000084497.10 ENSMUST00000084497.11 ENSMUST00000084497.2 ENSMUST00000084497.3 ENSMUST00000084497.4 ENSMUST00000084497.5 ENSMUST00000084497.6 ENSMUST00000084497.7 ENSMUST00000084497.8 ENSMUST00000084497.9 NM_198017 Z4YJY0 Z4YJY0_MOUSE uc009kcq.1 uc009kcq.2 uc009kcq.3 uc009kcq.4 Cytoplasm, cytoskeleton, spindle pole Nucleus Belongs to the FAM175 family. Abro1 subfamily. mitotic cell cycle response to ischemia cytoplasm centrosome chromosome segregation microtubule binding attachment of spindle microtubules to kinetochore midbody polyubiquitin binding spindle pole centrosome microtubule minus-end protein K63-linked deubiquitination BRISC complex mitotic spindle assembly uc009kcq.1 uc009kcq.2 uc009kcq.3 uc009kcq.4 
ENSMUST00000084500.8 Oat ENSMUST00000084500.8 ornithine aminotransferase (from RefSeq NM_016978.2) ENSMUST00000084500.1 ENSMUST00000084500.2 ENSMUST00000084500.3 ENSMUST00000084500.4 ENSMUST00000084500.5 ENSMUST00000084500.6 ENSMUST00000084500.7 NM_016978 Oat Q3TG75 Q3TG75_MOUSE uc009kcb.1 uc009kcb.2 uc009kcb.3 Reaction=a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L- glutamate 5-semialdehyde; Xref=Rhea:RHEA:13877, ChEBI:CHEBI:35179, ChEBI:CHEBI:46911, ChEBI:CHEBI:58066, ChEBI:CHEBI:59869; EC=2.6.1.13; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence= Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. catalytic activity ornithine-oxo-acid transaminase activity nucleoplasm cytoplasm mitochondrion transaminase activity transferase activity pyridoxal phosphate binding protein hexamerization uc009kcb.1 uc009kcb.2 uc009kcb.3 
ENSMUST00000084501.4 Pappa ENSMUST00000084501.4 pregnancy-associated plasma protein A (from RefSeq NM_021362.2) ENSMUST00000084501.1 ENSMUST00000084501.2 ENSMUST00000084501.3 NM_021362 PAPP1_MOUSE Q80VW3 Q80YY1 Q8K423 Q8R4K7 Q8R4K8 Q9ES06 Q9JK57 uc008thm.1 uc008thm.2 Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected. Reaction=Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5.; EC=3.4.24.79; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 (By similarity). Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R4K8-1; Sequence=Displayed; Name=2; IsoId=Q8R4K8-2; Sequence=VSP_012193; Detected in kidney, spleen, brain, ovary, breast, skin, prostate, uterus, and placenta. Belongs to the peptidase M43B family. endopeptidase activity metalloendopeptidase activity extracellular region extracellular space proteolysis female pregnancy peptidase activity metallopeptidase activity hydrolase activity response to follicle-stimulating hormone metal ion binding response to glucocorticoid uc008thm.1 uc008thm.2 
ENSMUST00000084502.7 Bub3 ENSMUST00000084502.7 BUB3 mitotic checkpoint protein, transcript variant 4 (from RefSeq NR_177983.1) BUB3_MOUSE ENSMUST00000084502.1 ENSMUST00000084502.2 ENSMUST00000084502.3 ENSMUST00000084502.4 ENSMUST00000084502.5 ENSMUST00000084502.6 NR_177983 P97397 Q6ZWM5 Q9WVA3 uc009kbq.1 uc009kbq.2 uc009kbq.3 uc009kbq.4 Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity). Regulates chromosome segregation during oocyte meiosis. Interacts with BUB1 and BUBR1. The BUB1/BUB3 complex interacts with MAD1L1. Interacts with ZNF207/BuGZ; leading to promote stability and kinetochore loading of BUB3 (By similarity). Nucleus Chromosome, centromere, kinetochore Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition. Poly-ADP-ribosylated by PARP1. Belongs to the WD repeat BUB3 family. Sequence=AAB39606.1; Type=Frameshift; Evidence=; mitotic sister chromatid segregation chromosome, centromeric region kinetochore condensed chromosome kinetochore nucleus nucleoplasm chromosome cell cycle chromosome segregation mitotic spindle assembly checkpoint attachment of spindle microtubules to kinetochore mitotic checkpoint complex protein localization to kinetochore ubiquitin binding cell division meiotic cell cycle regulation of chromosome segregation bub1-bub3 complex uc009kbq.1 uc009kbq.2 uc009kbq.3 uc009kbq.4 
ENSMUST00000084510.8 Whrn ENSMUST00000084510.8 whirlin, transcript variant 2 (from RefSeq NM_001008791.2) A2AGD2 Dfnb31 ENSMUST00000084510.1 ENSMUST00000084510.2 ENSMUST00000084510.3 ENSMUST00000084510.4 ENSMUST00000084510.5 ENSMUST00000084510.6 ENSMUST00000084510.7 I6MML6 I6MML7 Kiaa1526 NM_001008791 Q3TZC8 Q5MLF1 Q5MLF2 Q5MLF3 Q5MLF4 Q5MLF5 Q5MLF6 Q5MLF7 Q5MLF8 Q5MLF9 Q80TC2 Q80VW4 Q80VW5 WHRN_MOUSE Whrn uc008tgh.1 uc008tgh.2 uc008tgh.3 uc008tgh.4 This gene encodes a protein required for elongation and actin polymerization in the hair cell stereocilia. The encoded protein is localized to the cytoplasm and co-localizes with the growing end of actin filaments. Mutations in this gene have been linked to deafness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]. Involved in hearing and vision as member of the USH2 complex (PubMed:20502675). Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear (PubMed:15590699). Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear (PubMed:20502675, PubMed:24334608). In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport (PubMed:20502675). Forms homooligomers (PubMed:15590698, PubMed:25406310). Interacts (via C-terminal PDZ domain) with MYO15A; this interaction is necessary for localization of WHRN to stereocilia tips (PubMed:15654330, PubMed:15590698). Interacts (via C-terminal PDZ domain) with MPP1/p55 (PubMed:16829577, PubMed:17584769). Interacts with LRRC4C/NGL1 (PubMed:15590698). Interacts with MYO7A (PubMed:15590698). Interacts with RPGR (PubMed:22323458). Interacts with EPS8 (PubMed:21236676). Interacts with CASK. Interacts with CIB2 (By similarity). Component of USH2 complex, composed of ADGRV1, PDZD7, USH2A and WHRN (PubMed:20502675, PubMed:25406310). Interacts (via PDZ domains) with PDZD7; the interaction is direct (PubMed:25406310). Interacts (via N-terminal PDZ domain) with USH2A (via cytoplasmic region) (PubMed:16301217, PubMed:20502675, PubMed:23055499). Interacts with ADGRV1/MASS1 (via cytoplasmic region) (PubMed:20502675, PubMed:23055499). Q80VW5; Q8C031: Lrrc4c; NbExp=4; IntAct=EBI-7417603, EBI-7417983; Q80VW5; P70290: Mpp1; NbExp=4; IntAct=EBI-7417603, EBI-8315951; Q80VW5; Q9QZZ4: Myo15a; NbExp=5; IntAct=EBI-7417603, EBI-4281382; Q80VW5-12; Q9R0X5-5: Rpgr; NbExp=2; IntAct=EBI-6915655, EBI-6915646; Cytoplasm. Cell projection, stereocilium ll projection, growth cone Photoreceptor inner segment napse Note=Detected at the level of stereocilia in inner and outer hair cells of the cochlea and vestibule. Localizes to both tip and ankle-link stereocilia regions. Colocalizes with the growing ends of actin filaments (PubMed:15590699, PubMed:15590698, PubMed:15654330, PubMed:24334608). Colocalizes with MPP1 in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC) (PubMed:17584769). In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment that surrounds the connecting cilia called periciliary membrane complex (PubMed:20502675, PubMed:24334608). Event=Alternative splicing; Named isoforms=12; Name=1; IsoId=Q80VW5-1; Sequence=Displayed; Name=2; IsoId=Q80VW5-2; Sequence=VSP_029939, VSP_029941; Name=3; IsoId=Q80VW5-3; Sequence=VSP_029941; Name=4; IsoId=Q80VW5-4; Sequence=VSP_029941, VSP_029943; Name=5; IsoId=Q80VW5-5; Sequence=VSP_029937, VSP_029938, VSP_029941; Name=6; IsoId=Q80VW5-6; Sequence=VSP_029936; Name=7; IsoId=Q80VW5-7; Sequence=VSP_029936, VSP_029941; Name=8; IsoId=Q80VW5-8; Sequence=VSP_029935, VSP_029941; Name=9; IsoId=Q80VW5-9; Sequence=VSP_029934; Name=10; IsoId=Q80VW5-10; Sequence=VSP_029940, VSP_029942; Name=11; Synonyms=WhirlinNT2; IsoId=Q80VW5-11; Sequence=VSP_045294, VSP_045295; Name=12; Synonyms=WhirlinNT1; IsoId=Q80VW5-12; Sequence=VSP_045293; Expressed in the retina. Colocalizes with RPGR in the photoreceptor connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (at protein level). Detected in the inner ear throughout development from embryonic day 12 to 20 days after birth. Displays a dynamic pattern of expression after birth, demonstrating an ordered appearance and fade-out across stereocilia rows. Isoforms 5, 6, 7 and 8 are not detected in the retina (PubMed:20502675). At 10.5 dpc, expressed in the basal plate of the spinal cord, in the ventralneural epithelium of the developing brain and in the region of the lung bud. At 12.5 dpc, expressed in the complete neuroepithelium except for the neocortex. In the developing eye, expressed in the inner neuroblastic layer. At 14.5 dpc, detected in the intervertebral cartilage, the cortex of the developing kidney, the tongue, the region of the urethra and strongly in specific regions of the brain, e.g. striatum, optic recess, ventral tegmental area, roof of the midbrain, choroid plexus of the lateral ventricles and the fourth ventricle. The developing neocortex is devoid of expression. At this timepoint, expression is first notable in the inner ear in the developing maculae of the saccule and the utricle, in the cristae of the semicircular canals and in the vestibulocochlear ganglion. In the developing neural retina, a strong signal is present in the inner neuroblastic layer. At 16.5 dpc, expression is very similar to that at 14.5 dpc. At 18.5 dpc, expression is mainly as in 16.5 dpc. Expression in the ganglion layers of the retina decreases and is no longer detected in the innermost region of these layers. From postnatal day 7 (P7) onwards, also the developing photoreceptor cells express whirlin (PubMed:16434480). Expression decreases by 11 days after birth in inner ear hair cells and by 14 days after birth in outer ear hair cells. Expressed in vestibular hair cells at high levels through to adulthood. Note=Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them. Mutant mice for isoform 1 appear viable and comparable to their wild-type littermates in growth characteristics, reproductive performance and general health (PubMed:20502675). At 2 and 9 months of age, knockouts show a profound hearing loss across all cochlear frequencies (PubMed:20502675). At 28 to 33 months, they show signs for retinal degeneration such as a thinner photoreceptor nuclear layer and outer segments shortened (PubMed:20502675). [Isoform 3]: Major isoform. [Isoform 11]: May be due to intron retention. [Isoform 12]: May be due to intron retention. retina homeostasis photoreceptor inner segment stereocilia ankle link stereocilia ankle link complex protein binding cytoplasm actin filament plasma membrane cilium sensory perception of sound positive regulation of gene expression membrane protein domain specific binding cerebellar Purkinje cell layer formation cell junction axon dendrite growth cone photoreceptor connecting cilium stereocilium stereocilium bundle stereocilium tip ciliary basal body protein homodimerization activity cell projection neuronal cell body dendritic shaft establishment of protein localization synapse protein heterodimerization activity detection of mechanical stimulus involved in sensory perception of sound sensory perception of light stimulus auditory receptor cell stereocilium organization inner ear receptor stereocilium organization periciliary membrane compartment paranodal junction maintenance USH2 complex uc008tgh.1 uc008tgh.2 uc008tgh.3 uc008tgh.4 
ENSMUST00000084512.11 Tacc1 ENSMUST00000084512.11 transforming, acidic coiled-coil containing protein 1, transcript variant 2 (from RefSeq NM_199323.4) ENSMUST00000084512.1 ENSMUST00000084512.10 ENSMUST00000084512.2 ENSMUST00000084512.3 ENSMUST00000084512.4 ENSMUST00000084512.5 ENSMUST00000084512.6 ENSMUST00000084512.7 ENSMUST00000084512.8 ENSMUST00000084512.9 NM_199323 Q05A66 Q6Y685 Q6Y686 TACC1_MOUSE uc009lft.1 uc009lft.2 uc009lft.3 uc009lft.4 Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors (By similarity). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. Interacts with CH-TOG and YEATS4. Interacts with the AURKA and AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF (By similarity). Interacts with the thyroid hormone receptors THRB and THRA, predominantly with isoform alpha-2. The interaction with THRA isoform alpha-1 and THRB is decreased in the presence of thyroid hormone T3 (PubMed:20078863). Interacts with RARA in the nucleus (PubMed:20078863). Also interacts with other nuclear receptors, including ESR1, NR3C1, PPARG and RXRA, preferentially in the absence of their hormonal ligands (By similarity). Cytoplasm Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=Q6Y685-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q6Y685-2; Sequence=VSP_012650, VSP_012651; Belongs to the TACC family. microtubule cytoskeleton organization nucleus cytoplasm microtubule organizing center cytoskeleton cell cycle mitotic spindle organization cell proliferation ligand-dependent nuclear receptor binding protein domain specific binding cerebral cortex development neurogenesis interkinetic nuclear migration estrogen receptor binding midbody regulation of microtubule-based process glucocorticoid receptor binding retinoic acid receptor binding peroxisome proliferator activated receptor binding retinoid X receptor binding thyroid hormone receptor binding cell division positive regulation of ligand-dependent nuclear receptor transcription coactivator activity uc009lft.1 uc009lft.2 uc009lft.3 uc009lft.4 
ENSMUST00000084519.7 Wdr11 ENSMUST00000084519.7 WD repeat domain 11 (from RefSeq NM_172255.3) ENSMUST00000084519.1 ENSMUST00000084519.2 ENSMUST00000084519.3 ENSMUST00000084519.4 ENSMUST00000084519.5 ENSMUST00000084519.6 G5E8J3 G5E8J3_MOUSE NM_172255 Wdr11 uc009jzo.1 uc009jzo.2 uc009jzo.3 nucleus cytoplasm trans-Golgi network cytosol intracellular protein transport microtubule cytoskeleton cytoplasmic vesicle ciliary basal body vesicle tethering to Golgi uc009jzo.1 uc009jzo.2 uc009jzo.3 
ENSMUST00000084524.4 Prpf4 ENSMUST00000084524.4 pre-mRNA processing factor 4 (from RefSeq NM_027297.3) ENSMUST00000084524.1 ENSMUST00000084524.2 ENSMUST00000084524.3 NM_027297 PRP4_MOUSE Q9DAW6 uc008ter.1 uc008ter.2 uc008ter.3 Plays a role in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). Component of the precatalytic spliceosome (spliceosome B complex) (By similarity). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (By similarity). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity). Interacts directly with PRPF18, PPIH and PRPF3 (By similarity). Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA (By similarity). Interacts with ERCC6 (By similarity). Nucleus Nucleus speckle mRNA splicing, via spliceosome nucleus spliceosomal complex mRNA processing RNA splicing Cajal body nuclear speck U6 snRNA binding U4 snRNA binding U4/U6 x U5 tri-snRNP complex U4/U6 snRNP U2-type precatalytic spliceosome spliceosomal snRNP complex uc008ter.1 uc008ter.2 uc008ter.3 
ENSMUST00000084525.12 Cdc26 ENSMUST00000084525.12 cell division cycle 26, transcript variant 1 (from RefSeq NM_139291.4) CDC26_MOUSE ENSMUST00000084525.1 ENSMUST00000084525.10 ENSMUST00000084525.11 ENSMUST00000084525.2 ENSMUST00000084525.3 ENSMUST00000084525.4 ENSMUST00000084525.5 ENSMUST00000084525.6 ENSMUST00000084525.7 ENSMUST00000084525.8 ENSMUST00000084525.9 NM_139291 Q99JP4 uc290ncp.1 uc290ncp.2 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). Protein modification; protein ubiquitination. V-shaped homodimer. Interacts with CDC16. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. Nucleus Belongs to the CDC26 family. molecular_function nucleus nucleoplasm anaphase-promoting complex cell cycle regulation of mitotic cell cycle protein ubiquitination regulation of mitotic metaphase/anaphase transition anaphase-promoting complex-dependent catabolic process cell division protein K11-linked ubiquitination uc290ncp.1 uc290ncp.2 
ENSMUST00000084526.12 Slc31a1 ENSMUST00000084526.12 solute carrier family 31, member 1 (from RefSeq NM_175090.4) COPT1_MOUSE Ctr1 ENSMUST00000084526.1 ENSMUST00000084526.10 ENSMUST00000084526.11 ENSMUST00000084526.2 ENSMUST00000084526.3 ENSMUST00000084526.4 ENSMUST00000084526.5 ENSMUST00000084526.6 ENSMUST00000084526.7 ENSMUST00000084526.8 ENSMUST00000084526.9 NM_175090 Q3UAJ9 Q8BXJ1 Q8K211 Slc31a1 uc008ten.1 uc008ten.2 uc008ten.3 uc008ten.4 [High affinity copper uptake protein 1]: Uniporter that mediates the transport of copper(1+) from the extracellular space to the cytoplasm, across the plasma membrane (PubMed:11391005, PubMed:12177073, PubMed:16847145, PubMed:24167251). Then, delivers directly copper(1+) to specific chaperone such as ATOX1, via a copper(1+)- mediated transient interaction between the C-terminal domain and a copper(1+) chaperone, thus controlling intracellular copper(1+) levels (By similarity). May function in copper(1+) import from the apical membrane thus may drive intestinal copper absorption (PubMed:16950140). The copper(1+) transport mechanism is sodium- independent, saturable and of high-affinity (By similarity). Also mediates the uptake of silver(1+) (PubMed:20569931). May function in the influx of the platinum-containing chemotherapeutic agents (PubMed:16847145, PubMed:19144690, PubMed:12370430). The platinum- containing chemotherapeutic agents uptake is saturable (By similarity). Also participates in the first step of copper(2+) acquisition by cells through a direct transfer of copper(2+) from copper(2+) carriers in blood, such as ALB to the N-terminal domain of SLC31A1, leading to copper(2+) reduction and probably followed by copper(1+) stabilization (By similarity). In addition, functions as a redox sensor to promote angiogenesis in endothelial cells, in a copper(1+) transport independent manner, by transmitting the VEGF-induced ROS signal through a sulfenylation at Cys-195 leading to a subsequent disulfide bond formation between SLC31A1 and KDR (PubMed:35027734). The SLC31A1-KDR complex is then co-internalized to early endosomes, driving a sustained VEGFR2 signaling (By similarity). [Truncated CTR1 form]: Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells. Reaction=Cu(+)(out) = Cu(+)(in); Xref=Rhea:RHEA:75211, ChEBI:CHEBI:49552; Evidence= Reaction=Ag(+)(out) = Ag(+)(in); Xref=Rhea:RHEA:75207, ChEBI:CHEBI:49468; Evidence=; Homotrimer; is stabilized by cisplatin via interactions between cisplatin and the Met motif, and could be crucial for the copper(2+) reduction process and copper(1+) stabilization. Heterotrimer between SLC31A1, CCS and SOD1; this heterotrimer is copper(1+)-mediated and its maintenance is regulated through SOD1 activation. Interacts with KDR; this interaction is induced upon VEGFA stimulation leading to SLC31A1 and KDR subsequent co-internalization to early endosomes, thereby activating KDR downstream signaling in endothelial cells. Interacts (via C-terminal domain) with ATOX1 (via dimer form); this interaction improves ATOX1 stability and controls intracellular copper(1+) levels (By similarity). Interacts with SLC31A2; this interaction stabilizes SLC31A2 and protects its from ubiquitination and degradation (PubMed:24167251). Interacts (via C-terminal domain) with CCS; this interaction is copper(1+)-mediated (By similarity). Cell membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Apical cell membrane ulti-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Note=The localization is controlled by the intra and extra-cellular copper concentration. Under conditions of elevated extracellular copper concentrations, it is rapidly internalized by endocytosis from the plasma membrane by a clathrin- and dynamin-mediated process and degradated in order to prevent intracellular copper accumulation and to reduce the transport of the copper across the membrane. The internalized SLC31A1 is then localized in early endosomes, and, upon a low extracellular copper concentrations, it is transported back to the plasma membrane in a RAB11A-dependent recycling pathway (By similarity). Localizes to the apical membrane in intestinal epithelial cells (PubMed:20699218, PubMed:16950140). Mainly localized on the basolateral side of renal tubular cells (PubMed:19144690). Localizes to the neuronal cell body plasma membranes (By similarity). Expressed in the tubules in the inner cortex and inner medulla of the kidney, the villi of the small intestine, the choroid plexus of the brain, the stroma of the ovary, the seminiferous tubules of the testes, and the sclera of the eye (PubMed:11391004). Expressed in intestinal epithelial cells, with an increase expression from the crypt to the tip of the villus (PubMed:16950140). Mainly expressed in both proximal and distal tubular cells in kidneys (PubMed:19144690). At E14.5, expressed in the forebrain, liver, nasal regions, and somites (PubMed:11391004). By E16.5, expression is ubiquitous, with high expression in the liver, intestine, somites, and choroid plexus (PubMed:11391004). By E18.5 expression is more restricted to the choroid plexus, kidney, intestine, and tooth buds (PubMed:11391004). Expressed principally by Sertoli cells (SCs) and the spermatocytes with the highest expression in the primary pachytene spermatocytes within seminiferous tubule stages II-VI (PubMed:31002737). The C-terminal domain mediates copper(1+) binding and is involved in the copper(1+)-dependent-ATOX1 interaction. The C-terminal domain appears to act to limit transport through the pore by regulating the rate of exit of copper ions at the intracellular side. The N- terminal domain can collect copper(2+) from copper(2+) carriers in blood. The N-terminal domain, in the trimeric arrangement, tunes its reactivity with copper, promoting copper(2+) reduction and copper(1+) stabilization. The bis-His motif directly coordinate to copper(2+). O-Glycosylation at Thr-34 protects from proteolytic cleavage in the N-terminal extracellular domain. Proteolytic cleavage, leading to a truncated form, is facilitated by SLC31A2 (PubMed:24167251) and initiated preferentially by CTSL and to a minor extend by CTSB in endolysosomal compartments (PubMed:27143361, PubMed:24167251). A post-CTSL/cathepsin L processing occurs to yield to the fully truncated form (PubMed:27143361). Sulfenylated at Cys-195 after stimulation with VEGFA, which induces SLC31A1-KDR disulfide bond formation and their co- internalization to early endosomes, driving to a sustained VEGFR2 signaling. Homozygous mice lacking Slc31a1 exhibit profound growth and developmental defects and die in utero in mid-gestation (PubMed:11391005, PubMed:11391004). Homozygous embryos exhibit a dramatic reduction in size at E7.5, which is exacerbated during the progression of in utero development through day E10.5 (PubMed:11391005). Although the fundamental mouse embryonic structures are conserved at E7.5, homozygous embryos show that many structures including the neural ectoderm and mesoderm cell layers are poorly developed (PubMed:11391005). Conditional knockout mice lacking Slc31a1 in intestinal epithelial cells, are born at the expected frequency and exhibit normal growth rate and mass for the first 6-8 days postpartum, poor growth and lethality occurred beginning approximately 10 days after birth (PubMed:16950140). Conditional knockout mice lacking Slc31a1 in germ cells (GCs) seem normal in appearance (PubMed:31002737). Conditional knockout mice lacking Slc31a1 in Sertoli cells (SCs) exhibit normal fertility and display similar appearance as their wild-type littermates; no obvious behavioral deficit are noted (PubMed:31002737). Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. copper ion transmembrane transporter activity protein binding cytoplasm late endosome plasma membrane ion transport copper ion transport drug transmembrane transport cellular copper ion homeostasis copper ion import membrane integral component of membrane copper ion transmembrane transport identical protein binding neuronal cell body recycling endosome cellular response to cisplatin copper ion import across plasma membrane uc008ten.1 uc008ten.2 uc008ten.3 uc008ten.4 
ENSMUST00000084527.10 Fkbp15 ENSMUST00000084527.10 FK506 binding protein 15, transcript variant 2 (from RefSeq NM_001355385.2) ENSMUST00000084527.1 ENSMUST00000084527.2 ENSMUST00000084527.3 ENSMUST00000084527.4 ENSMUST00000084527.5 ENSMUST00000084527.6 ENSMUST00000084527.7 ENSMUST00000084527.8 ENSMUST00000084527.9 FKB15_MOUSE Fkbp133 Kiaa0674 NM_001355385 Q3TSY4 Q5SQG3 Q6P9Q6 Q80TU5 uc008teh.1 uc008teh.2 uc008teh.3 uc008teh.4 Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement (By similarity). May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase. Interacts with WIP and actin (By similarity). Interacts with TBC1D23 (PubMed:29084197). Cytoplasm Cell projection, axon Early endosome Note=Present in axons and neuronal growth cones. Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=Q6P9Q6-1; Sequence=Displayed; Name=B; IsoId=Q6P9Q6-2; Sequence=VSP_027759; Expressed in brain, with highest levels in the granular cell layer of cerebellum and in the granule cell layer of dentate gyrus. Strongly expressed in the developing nervous system at 18.5 dpc. Present in brain, heart, lung, kidney and thymus at 18.5 dpc (at protein level). The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity. The central coiled-coil region is responsible for association with early endosomes. Belongs to the FKBP-type PPIase family. protein peptidyl-prolyl isomerization actin binding cytoplasm endosome early endosome endocytosis negative regulation of phosphatase activity membrane axon growth cone cell projection actin filament peptidyl-prolyl cis-trans isomerase activity uc008teh.1 uc008teh.2 uc008teh.3 uc008teh.4 
ENSMUST00000084530.9 Slc31a2 ENSMUST00000084530.9 solute carrier family 31, member 2, transcript variant 1 (from RefSeq NM_025286.3) COPT2_MOUSE ENSMUST00000084530.1 ENSMUST00000084530.2 ENSMUST00000084530.3 ENSMUST00000084530.4 ENSMUST00000084530.5 ENSMUST00000084530.6 ENSMUST00000084530.7 ENSMUST00000084530.8 NM_025286 Q9CPU9 Slc31a2 uc008tee.1 uc008tee.2 uc008tee.3 uc008tee.4 Does not function as a copper(1+) importer in vivo (PubMed:24167251). However, in vitro functions as a low-affinity copper(1+) importer (By similarity). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (PubMed:24167251). Oligomer. Interacts with SLC31A1; this interaction stabilizes SLC31A2 and protects it from ubiquitination and the subsequent degradation. Membrane ; Multi- pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Note=Plasma membrane localization is partial (By similarity). Localizes in endosomes recycling from and to the plasma membrane, as well as in late endosomes trafficking to the trans-Golgi network (TGN) (PubMed:24167251). The N-terminal domain may be involved in Cu(2+) acquisition from potential degradation products of proteins in the lysosome. Ubiquitinated; ubiquitination and the subsequent proteasomal degradation are prevent by SLC31A1 that stabilizes it. Homozygous knockout mice lacking Slc31a2 grow normally, with no obvious developmental defects. Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. protein binding late endosome plasma membrane ion transport cellular copper ion homeostasis membrane integral component of membrane copper ion transmembrane transport recycling endosome regulation of copper ion transmembrane transport copper ion transmembrane transporter activity copper ion transport uc008tee.1 uc008tee.2 uc008tee.3 uc008tee.4 
ENSMUST00000084531.11 Mup3 ENSMUST00000084531.11 major urinary protein 3, transcript variant 1 (from RefSeq NM_001039544.2) CT990635.2-001 ENSMUST00000084531.1 ENSMUST00000084531.10 ENSMUST00000084531.2 ENSMUST00000084531.3 ENSMUST00000084531.4 ENSMUST00000084531.5 ENSMUST00000084531.6 ENSMUST00000084531.7 ENSMUST00000084531.8 ENSMUST00000084531.9 Mup25 Mup3 Mup6 NM_001039544 Q3KQQ2 Q3KQQ2_MOUSE uc008tbs.1 uc008tbs.2 uc008tbs.3 uc008tbs.4 Secreted Belongs to the calycin superfamily. Lipocalin family. small molecule binding uc008tbs.1 uc008tbs.2 uc008tbs.3 uc008tbs.4 
ENSMUST00000084535.6 Amer1 ENSMUST00000084535.6 APC membrane recruitment 1 (from RefSeq NM_175179.4) AMER1_MOUSE B1AUM2 ENSMUST00000084535.1 ENSMUST00000084535.2 ENSMUST00000084535.3 ENSMUST00000084535.4 ENSMUST00000084535.5 Fam123b NM_175179 Q7TS75 Q8BT92 Q8C7P7 uc009ttx.1 uc009ttx.2 uc009ttx.3 uc009ttx.4 uc009ttx.5 Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development (By similarity). Interacts with CTNNB1, AXIN1, LRP6, KEAP1, APC and BTRC. Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes containing BTRC and/or FBXW11. Identified in the beta- catenin destruction complex containing CTNNB1, APC, AXIN1 and AXIN2. Interacts with WT1 (By similarity). Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2 (By similarity). Expressed in kidney. In embryos, it is highly expressed in the neonatal brain and kidney and then declines substantially in the mature organs. Also expressed in lung and spleen. Expressed in the condensing metanephric mesenchyme and in early epithelial structures that are precursors to glomeruli. Belongs to the Amer family. Sequence=AAH53442.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC25373.1; Type=Frameshift; Evidence=; Sequence=BAC33914.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; kidney development phosphatidylinositol-4,5-bisphosphate binding nucleus cytoplasm plasma membrane beta-catenin binding lipid binding membrane Wnt signaling pathway nuclear body positive regulation of protein ubiquitination intracellular membrane-bounded organelle bone development adipose tissue development regulation of canonical Wnt signaling pathway mesenchymal cell differentiation involved in kidney development negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of cellular protein catabolic process beta-catenin destruction complex binding uc009ttx.1 uc009ttx.2 uc009ttx.3 uc009ttx.4 uc009ttx.5 
ENSMUST00000084563.11 Tmem265 ENSMUST00000084563.11 transmembrane protein 265 (from RefSeq NM_001304267.1) E9Q8G3 E9Q8G3_MOUSE ENSMUST00000084563.1 ENSMUST00000084563.10 ENSMUST00000084563.2 ENSMUST00000084563.3 ENSMUST00000084563.4 ENSMUST00000084563.5 ENSMUST00000084563.6 ENSMUST00000084563.7 ENSMUST00000084563.8 ENSMUST00000084563.9 NM_001304267 Srcap Tmem265 uc291vvt.1 uc291vvt.2 Belongs to the CD225/Dispanin family. membrane integral component of membrane uc291vvt.1 uc291vvt.2 
ENSMUST00000084564.10 Zfp629 ENSMUST00000084564.10 zinc finger protein 629, transcript variant 4 (from RefSeq NR_155450.2) ENSMUST00000084564.1 ENSMUST00000084564.2 ENSMUST00000084564.3 ENSMUST00000084564.4 ENSMUST00000084564.5 ENSMUST00000084564.6 ENSMUST00000084564.7 ENSMUST00000084564.8 ENSMUST00000084564.9 Kiaa0326 NR_155450 Q6A085 Q8BG88 Q8BIR0 ZN629_MOUSE Znf629 uc009jwj.1 uc009jwj.2 uc009jwj.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAD32211.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding nucleus metal ion binding uc009jwj.1 uc009jwj.2 uc009jwj.3 
ENSMUST00000084589.11 Cln3 ENSMUST00000084589.11 CLN3 lysosomal/endosomal transmembrane protein, battenin, transcript variant 1 (from RefSeq NM_001146311.3) CLN3_MOUSE Cln3 ENSMUST00000084589.1 ENSMUST00000084589.10 ENSMUST00000084589.2 ENSMUST00000084589.3 ENSMUST00000084589.4 ENSMUST00000084589.5 ENSMUST00000084589.6 ENSMUST00000084589.7 ENSMUST00000084589.8 ENSMUST00000084589.9 NM_001146311 O35934 P70400 Q61124 uc291vku.1 uc291vku.2 This gene encodes a transmembrane protein called battenin that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis genes, cause a number of neurodegenerative diseases collectively known as neuronal ceroid lipofuscinoses, the most common of which is juvenile neuronal ceroid-lipofuscinosis (Batten disease). Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]. Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor- mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission (PubMed:10191118, PubMed:24227717, PubMed:15588329, PubMed:29780879, PubMed:26450516, PubMed:16714284, PubMed:25878248, PubMed:17855597). Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing (PubMed:24227717). Moreover regulates CTSD activity in response to osmotic stress (By similarity). Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis (PubMed:10191118). At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex (PubMed:18621045, PubMed:24792215). Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age- dependent anxious behavior, learning and memory (PubMed:29135436, PubMed:29780879). Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process (PubMed:16714284, PubMed:25878248, PubMed:26450516). Participates also in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis (PubMed:19284480, PubMed:20219947, PubMed:25878248). Homooligomer (PubMed:11590129). Interacts with DCTN1, KIF3A, RAB7A and RILP (By similarity). Interacts with CLN5 (PubMed:19941651). Interacts with KCNIP3 (PubMed:17189291). Lysosome membrane ; Multi-pass membrane protein Late endosome Lysosome mbrane raft Golgi apparatus, trans-Golgi network Synapse, synaptosome Early endosome membrane Late endosome membrane Cytoplasmic vesicle, autophagosome Note=Excluded from the synaptic vesicles. Expressed throughout the brain, such as, in the cerebral cortex, hippocampus, cerebellum and several different cerebral nuclei (at protein level). In the cerebral cortex, expressed in all cortical layers. In the hippocampus, expressed in the granule cells in the dentate gyrus and the pyramidal cells of the hippocampus proper. In the cerebellum expressed in the granular and molecular layers, and in the Purkinje cell layer. Expression is osmoregulated in renal medullary cells. Highly glycosylated. Farnesylation is important for trafficking to lysosomes. Embryos are viable and fertile and by 12 months of age do not exhibit obvious clinical signs but have significantly shortened life spans (PubMed:10527801, PubMed:17962032). Mice show elevation of lysosomal enzymes in brain and accumulation of autofluorescent storage material in neurons, retina and other cell types that increases with age (PubMed:10527801, PubMed:10440905, PubMed:17962032, PubMed:17855597). They also show neuropathological abnormalities with loss of certain cortical interneurons and hypertrophy of many interneuron populations in the hippocampus (PubMed:10527801). Moreover display progressive neurological deficits, including impaired motor function, decreased overall activity, acquisition of resting tremors, and increased susceptibility to pentilentetrazole-induced seizures (PubMed:17855597). Mice exhibit progressively impaired inner retinal function, altered pupillary light reflexes, losses of inner retinal neurons, and reduced brain mass. Mice show behavioral changes including reduced spontaneous activity levels and impaired learning and memory (PubMed:17962032). Cln3 hypomorphic mutant mice, harboring the ~1 kb common juvenile neuronal ceroid lipofuscinosis (JNCL) mutation, express multiple Cln3 mRNA splice variants and mutant battenin protein. Homozygous Cln3 mice exhibit a progressive JNCL-like disease, with perinatal onset of subunit c of ATP synthasedeposition in many cell types and later onset of neuronal dysfunction and behavioral deficits (PubMed:12374761). Can serve as an animal model for studying neuronal ceroid lipofuscinosis 3/Batten disease (PubMed:10527801, PubMed:10440905, PubMed:17962032, PubMed:12374761). Belongs to the battenin family. Golgi membrane action potential positive regulation of protein phosphorylation protein binding nucleus cytoplasm lysosome lysosomal membrane endosome early endosome late endosome autophagosome endoplasmic reticulum Golgi apparatus Golgi stack trans-Golgi network plasma membrane caveola amino acid transport endocytosis receptor-mediated endocytosis lysosome organization lysosomal lumen acidification synaptic vesicle associative learning regulation of gene expression arginine transport membrane integral component of membrane macroautophagy cell migration protein processing actin cytoskeleton organization integral component of endoplasmic reticulum membrane cytoplasmic vesicle ionotropic glutamate receptor signaling pathway lysosomal lumen pH elevation neurotransmitter metabolic process amyloid precursor protein catabolic process neuron projection negative regulation of apoptotic process negative regulation of catalytic activity negative regulation of neuron apoptotic process membrane raft negative regulation of proteolysis vesicle transport along microtubule calcium-dependent protein binding neuromuscular process controlling balance regulation of intracellular pH regulation of cytosolic calcium ion concentration regulation of filopodium assembly membrane organization protein localization to membrane protein localization to plasma membrane autophagosome maturation uc291vku.1 uc291vku.2 
ENSMUST00000084593.3 6030445D17Rik ENSMUST00000084593.3 6030445D17Rik (from geneSymbol) ENSMUST00000084593.1 ENSMUST00000084593.2 LF194699 uc290qyv.1 uc290qyv.2 uc290qyv.1 uc290qyv.2 
ENSMUST00000084615.10 Cacng3 ENSMUST00000084615.10 calcium channel, voltage-dependent, gamma subunit 3 (from RefSeq NM_019430.2) A6H6R5 CCG3_MOUSE ENSMUST00000084615.1 ENSMUST00000084615.2 ENSMUST00000084615.3 ENSMUST00000084615.4 ENSMUST00000084615.5 ENSMUST00000084615.6 ENSMUST00000084615.7 ENSMUST00000084615.8 ENSMUST00000084615.9 NM_019430 Q9JJV5 uc009jov.1 uc009jov.2 uc009jov.3 uc009jov.4 uc009jov.5 uc009jov.6 Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs) (PubMed:18341993). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit- specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts with AP4M1 and GRIA1; associates GRIA1 with the adaptor protein complex 4 (AP-4) to target GRIA1 to the somatodendritic compartment of neurons (PubMed:18341993). Membrane ; Multi-pass membrane protein Note=Displays a somatodendritic localization and is excluded from axons in neurons. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity protein binding protein targeting ion transport calcium ion transport protein localization membrane integral component of membrane transmission of nerve impulse PDZ domain binding dendrite AMPA glutamate receptor complex regulation of ion transmembrane transport ionotropic glutamate receptor binding somatodendritic compartment excitatory synapse calcium ion transmembrane transport postsynaptic density membrane neurotransmitter receptor transport, postsynaptic endosome to lysosome postsynaptic neurotransmitter receptor diffusion trapping glutamatergic synapse integral component of postsynaptic density membrane neurotransmitter receptor internalization neurotransmitter receptor localization to postsynaptic specialization membrane regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc009jov.1 uc009jov.2 uc009jov.3 uc009jov.4 uc009jov.5 uc009jov.6 
ENSMUST00000084621.12 Tbc1d2 ENSMUST00000084621.12 TBC1 domain family, member 2 (from RefSeq NM_198664.3) B1AVH7 ENSMUST00000084621.1 ENSMUST00000084621.10 ENSMUST00000084621.11 ENSMUST00000084621.2 ENSMUST00000084621.3 ENSMUST00000084621.4 ENSMUST00000084621.5 ENSMUST00000084621.6 ENSMUST00000084621.7 ENSMUST00000084621.8 ENSMUST00000084621.9 NM_198664 Q3UFW9 Q8BYB1 TBD2A_MOUSE Tbc1d2a uc008suf.1 uc008suf.2 uc008suf.3 Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity). Interacts with activated RAC1 and CDH1. Cytoplasm Cytoplasmic vesicle Cell junction Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B1AVH7-1; Sequence=Displayed; Name=2; IsoId=B1AVH7-2; Sequence=VSP_039384; GTPase activator activity nucleus cytoplasm cytosol intracellular protein transport Rab GTPase binding cell junction cytoplasmic vesicle positive regulation of GTPase activity cadherin binding activation of GTPase activity uc008suf.1 uc008suf.2 uc008suf.3 
ENSMUST00000084628.5 Hs3st2 ENSMUST00000084628.5 heparan sulfate (glucosamine) 3-O-sulfotransferase 2, transcript variant 2 (from RefSeq NM_001419197.1) 3ost2 ENSMUST00000084628.1 ENSMUST00000084628.2 ENSMUST00000084628.3 ENSMUST00000084628.4 HS3S2_MOUSE NM_001419197 Q673U1 Q8BLP1 Q8C055 uc009jnr.1 uc009jnr.2 uc009jnr.3 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (By similarity). Catalyzes the O-sulfation of glucosamine in GlcA2S- GlcNS (By similarity). Unlike HS3ST1/3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:15461, Rhea:RHEA- COMP:9830, Rhea:RHEA-COMP:9831, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:70975; EC=2.8.2.29; Evidence=; Golgi apparatus membrane ; Single- pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q673U1-1; Sequence=Displayed; Name=2; IsoId=Q673U1-2; Sequence=VSP_013179, VSP_013180, VSP_013181, VSP_013182; Belongs to the sulfotransferase 1 family. Golgi membrane cellular_component Golgi apparatus circadian rhythm sulfotransferase activity [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity membrane integral component of membrane transferase activity [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity uc009jnr.1 uc009jnr.2 uc009jnr.3 
ENSMUST00000084640.3 Abca14 ENSMUST00000084640.3 ATP-binding cassette, sub-family A member 14 (from RefSeq NM_026458.4) Abca14 E9Q8F8 E9Q8F8_MOUSE ENSMUST00000084640.1 ENSMUST00000084640.2 NM_026458 uc009jmn.1 uc009jmn.2 Membrane ; Multi- pass membrane protein nucleotide binding lipid transporter activity ATP binding lipid transport membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances intracellular membrane-bounded organelle transmembrane transport uc009jmn.1 uc009jmn.2 
ENSMUST00000084646.11 Spag8 ENSMUST00000084646.11 sperm associated antigen 8, transcript variant 1 (from RefSeq NM_001290462.2) B9EKF1 ENSMUST00000084646.1 ENSMUST00000084646.10 ENSMUST00000084646.2 ENSMUST00000084646.3 ENSMUST00000084646.4 ENSMUST00000084646.5 ENSMUST00000084646.6 ENSMUST00000084646.7 ENSMUST00000084646.8 ENSMUST00000084646.9 NM_001290462 Q3V0Q6 Q5UAV3 SPAG8_MOUSE Spag8 uc008sqq.1 uc008sqq.2 uc008sqq.3 uc008sqq.4 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (PubMed:20488182). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (PubMed:17187156). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (By similarity). May play a role in fertility and microtubule formation through interaction with RANBP9 (By similarity). Interacts with FHL5 (via second LIM domain) (PubMed:20488182). Interacts with RANBP9 (By similarity). Q3V0Q6; Q9WTX7: Fhl5; NbExp=5; IntAct=EBI-7981981, EBI-7530396; Cytoplasm Nucleus Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasm, cytoskeleton, microtubule organizing center Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, cilium axoneme Note=In mature sperm cells, detected in the acrosomal region of the head and in the middle piece of the tail (PubMed:20488182). Localized to the nucleus and cytoplasm of spermatocytes and round spermatids while, in elongating spermatids, expressed in the cytoplasm but not in the nucleus (PubMed:20488182). During the cell cycle, localized on the microtubule-organizing center (MTOC) during prophase. In metaphase, extends along spindle microtubules. In anaphase, detected on the astral microtubules and mid- zone. In telophase, remains at the mid-zone. After cytokinesis, returns to the MTOC (By similarity). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3V0Q6-1; Sequence=Displayed; Name=2; IsoId=Q3V0Q6-2; Sequence=VSP_058322, VSP_058323; Expressed in testis (at protein level). Not detected in brain, heart, kidney, spleen, liver, lung, thymus and colon (at protein level). In the testis, expressed at low levels at 3 weeks with levels markedly elevated by 4 weeks and into adulthood (at protein level). Belongs to the SPAG8 family. acrosomal vesicle protein binding nucleus cytoplasm spindle cytoskeleton cell cycle spermatogenesis single fertilization microtubule binding cell differentiation cytoplasmic vesicle positive regulation of protein binding positive regulation of transcription from RNA polymerase II promoter uc008sqq.1 uc008sqq.2 uc008sqq.3 uc008sqq.4 
ENSMUST00000084650.6 Gpr139 ENSMUST00000084650.6 G protein-coupled receptor 139 (from RefSeq NM_001024138.2) ENSMUST00000084650.1 ENSMUST00000084650.2 ENSMUST00000084650.3 ENSMUST00000084650.4 ENSMUST00000084650.5 GP139_MOUSE Gm495 Gprg1 NM_001024138 Pgr3 Q059X1 Q80UC8 uc009jky.1 uc009jky.2 uc009jky.3 Orphan receptor. Seems to act through a G(q/11)-mediated pathway. Cell membrane; Multi-pass membrane protein. Expressed almost exclusively in the brain. Abundantly expressed in the ventrolateral region of caudate putamen, the habenular nucleus, the zona incerta, and the medial mammillary nucleus. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway neuropeptide signaling pathway neuropeptide receptor activity membrane integral component of membrane identical protein binding uc009jky.1 uc009jky.2 uc009jky.3 
ENSMUST00000084653.4 ENSMUSG00000072963 ENSMUST00000084653.4 ENSMUSG00000072963 (from geneSymbol) ENSMUST00000084653.1 ENSMUST00000084653.2 ENSMUST00000084653.3 uc287ycd.1 uc287ycd.2 uc287ycd.1 uc287ycd.2 
ENSMUST00000084675.4 Mir669c ENSMUST00000084675.4 microRNA 669c (from RefSeq NR_030473.1) ENSMUST00000084675.1 ENSMUST00000084675.2 ENSMUST00000084675.3 NR_030473 uc057lbw.1 uc057lbw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lbw.1 uc057lbw.2 
ENSMUST00000084695.12 Galt ENSMUST00000084695.12 galactose-1-phosphate uridyl transferase, transcript variant 1 (from RefSeq NM_016658.4) A2AMS3 A2AMS3_MOUSE ENSMUST00000084695.1 ENSMUST00000084695.10 ENSMUST00000084695.11 ENSMUST00000084695.2 ENSMUST00000084695.3 ENSMUST00000084695.4 ENSMUST00000084695.5 ENSMUST00000084695.6 ENSMUST00000084695.7 ENSMUST00000084695.8 ENSMUST00000084695.9 Galt NM_016658 uc008sjo.1 uc008sjo.2 uc008sjo.3 uc008sjo.4 uc008sjo.5 The protein encoded by this gene is the second enzyme in the Leloir pathway, the metabolic pathway for D-galactose catabolism. It catalyzes the conversion of galactose-1-phosphate and uridine diphosphate-glucose to glucose-1-phosphate and uridine diphosphate galactose. Deficiency of this enzyme causes the genetic metabolic disorder galactosemia. Mice lacking this protein accumulate high levels of galactose and galactose-1 phosphate but are viable and fertile. This protein is negatively regulated through signaling by the polypeptide hormone prolactin, specifically via the short isoform of the prolactin receptor and the transcription factor Forkhead box O3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D- glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989, ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence= Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Note=Binds 1 Fe cation per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Carbohydrate metabolism; galactose metabolism. Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. Golgi apparatus carbohydrate metabolic process UDP-glucose metabolic process galactose metabolic process UDP-glucose catabolic process UDP-glucose:hexose-1-phosphate uridylyltransferase activity zinc ion binding transferase activity nucleotidyltransferase activity galactose catabolic process via UDP-galactose metal ion binding uc008sjo.1 uc008sjo.2 uc008sjo.3 uc008sjo.4 uc008sjo.5 
ENSMUST00000084713.6 Gm10475 ENSMUST00000084713.6 predicted gene 10475 (from RefSeq NR_188780.1) ENSMUST00000084713.1 ENSMUST00000084713.2 ENSMUST00000084713.3 ENSMUST00000084713.4 ENSMUST00000084713.5 NR_188780 uc290tls.1 uc290tls.2 uc290tls.3 uc290tls.1 uc290tls.2 uc290tls.3 
ENSMUST00000084731.5 Ipo7 ENSMUST00000084731.5 importin 7, transcript variant 1 (from RefSeq NM_181517.5) ENSMUST00000084731.1 ENSMUST00000084731.2 ENSMUST00000084731.3 ENSMUST00000084731.4 IPO7_MOUSE NM_181517 Q7TN09 Q7TQ63 Q8BKD8 Q8BYI0 Q9EPL8 Ranbp7 uc009jeu.1 uc009jeu.2 uc009jeu.3 Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (By similarity). In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation (By similarity). Promotes odontoblast differentiation via promoting nuclear translocation of DLX3, KLF4, SMAD2, thereby facilitating the transcription of target genes that play a role in odontoblast differentiation (PubMed:33548622, PubMed:35922041). Facilitates BMP4-induced translocation of SMAD1 to the nucleus and recruitment to the MSX1 gene promoter, thereby promotes the expression of the odontogenic regulator MSX1 in dental mesenchymal cells (PubMed:34995814). Also promotes odontoblast differentiation by facilitating the nuclear translocation of HDAC6 and subsequent repression of RUNX2 expression (PubMed:35922041). Inhibits osteoblast differentiation by inhibiting nuclear translocation of RUNX2 and therefore inhibition of RUNX2 target gene transcription (PubMed:35922041). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (PubMed:11493596). Forms a heterodimer with KPNB1 (By similarity). Interacts with histone H1 (By similarity). Interacts with H2A, H2B, H3 and H4 histones (PubMed:11493596). Interacts with SNUPN and XPO1 (By similarity). Interacts with RPS7 and RPL5 (By similarity). Interacts with RPL23A (via BIB domain) (By similarity). Binds directly to nuclear pore complexes (By similarity). Interacts with SMAD4 and NUP93; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling (By similarity). Interacts with phosphorylated SMAD2; the interaction facilitates translocation of SMAD2 to the nucleus (PubMed:33548622). Interacts with SRP19 (By similarity). Interacts with RUNX2; the interaction inhibits RUNX2 nuclear translocation in osteoblasts (PubMed:35922041). Interacts with HDAC6, DLX3 and KLF4; the interaction facilitates HDAC6, DLX3 and KLF4 nuclear translocation in dental papilla cells (PubMed:35922041). Cytoplasm cleus te=Localizes to the nucleus in the presence of BMP4. Abundantly expressed in dental epithelial cells, with lower expression in dental mesenchymal cells of the lower molars at 12.5 and 18.5 dpc (at protein level) (PubMed:35922041). Weakly expressed in pre-odontoblasts and papilla cells, moderately expressed in polarizing odontoblasts and abundantly expressed in secretory and mature odontoblasts at birth (at protein level) (PubMed:35922041). Expressed in dental mesenchymal cells at birth (at protein level) (PubMed:34995814). Strongly expressed in differentiated odontoblasts of molars at 1, 3 and 9 days of age (at protein level) (PubMed:35922041). Induced by odontoblastic differentiation in dental papilla cells. Belongs to the importin beta family. protein binding nucleus nuclear envelope nucleoplasm cytoplasm cytosol protein import into nucleus intracellular protein transport Ran GTPase binding protein transport histone binding innate immune response SMAD binding uc009jeu.1 uc009jeu.2 uc009jeu.3 
ENSMUST00000084733.7 Tmem42 ENSMUST00000084733.7 transmembrane protein 42, transcript variant 1 (from RefSeq NM_025339.4) ENSMUST00000084733.1 ENSMUST00000084733.2 ENSMUST00000084733.3 ENSMUST00000084733.4 ENSMUST00000084733.5 ENSMUST00000084733.6 NM_025339 Q9CR22 TMM42_MOUSE uc009sfn.1 uc009sfn.2 uc009sfn.3 uc009sfn.4 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009sfn.1 uc009sfn.2 uc009sfn.3 uc009sfn.4 
ENSMUST00000084743.7 Pomgnt2 ENSMUST00000084743.7 protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2, transcript variant 4 (from RefSeq NM_153540.5) Ago61 ENSMUST00000084743.1 ENSMUST00000084743.2 ENSMUST00000084743.3 ENSMUST00000084743.4 ENSMUST00000084743.5 ENSMUST00000084743.6 Eogtl Gtdc2 NM_153540 PMGT2_MOUSE Q58F17 Q8BW41 Q8BXZ9 Q8K0M5 uc009sek.1 uc009sek.2 uc009sek.3 uc009sek.4 O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein (By similarity). Involved in the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:24256719). Reaction=3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl- alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha- D-mannosyl)-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:37663, Rhea:RHEA-COMP:13547, Rhea:RHEA-COMP:13618, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:137323, ChEBI:CHEBI:137540; EC=2.4.1.312; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Mainly expressed in the central nervous system. Expressed during brain development. At 14.5 dpc, expressed throughout the cortical plate and the developing brain, as well as throughout the eye, including the lens and cornea. Cortical expression is already detected at 12.5 dpc, peaks between 14.5 and 16.5 dpc and is reduced at birth. Newborns are slightly smaller and die within the first day of birth due to abnormal basal lamina formation and neuronal migration defects. Defects are due to a lack of laminin-binding glycans. Belongs to the glycosyltransferase 61 family. Sequence=BAC31348.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC35765.1; Type=Frameshift; Evidence=; neuron migration endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein O-linked mannosylation protein O-GlcNAc transferase activity uc009sek.1 uc009sek.2 uc009sek.3 uc009sek.4 
ENSMUST00000084750.8 Ankrd6 ENSMUST00000084750.8 ankyrin repeat domain 6, transcript variant 4 (from RefSeq NM_001355587.1) A2ANZ0 ANKR6_MOUSE ENSMUST00000084750.1 ENSMUST00000084750.2 ENSMUST00000084750.3 ENSMUST00000084750.4 ENSMUST00000084750.5 ENSMUST00000084750.6 ENSMUST00000084750.7 Kiaa0957 NM_001355587 Q69ZU8 Q6P1A8 Q8VHD9 uc008sfj.1 uc008sfj.2 This gene encodes a protein which is thought to be involved in the Wnt signaling pathway and embryonic axis formation. Similar genes have been found in human, rhesus macaque, and zebrafish. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. Interacts with AXN1, AXN2 and CSNK1E/CKI-epsilon. Q69ZU8-1; Q60838: Dvl2; NbExp=3; IntAct=EBI-15605686, EBI-641940; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69ZU8-1; Sequence=Displayed; Name=2; IsoId=Q69ZU8-2; Sequence=VSP_031592; protein binding nucleus cytoplasm intracellular membrane-bounded organelle positive regulation of JNK cascade negative regulation of canonical Wnt signaling pathway positive regulation of Wnt signaling pathway, planar cell polarity pathway uc008sfj.1 uc008sfj.2 
ENSMUST00000084754.3 Or10a48 ENSMUST00000084754.3 olfactory receptor family 10 subfamily A member 48 (from RefSeq NM_146726.1) ENSMUST00000084754.1 ENSMUST00000084754.2 NM_146726 Olfr514 Or10a48 Q8VFZ6 Q8VFZ6_MOUSE uc009jcw.1 uc009jcw.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jcw.1 uc009jcw.2 
ENSMUST00000084763.5 Nlrp14 ENSMUST00000084763.5 NLR family, pyrin domain containing 14 (from RefSeq NM_001002894.2) B2RUL1 ENSMUST00000084763.1 ENSMUST00000084763.2 ENSMUST00000084763.3 ENSMUST00000084763.4 NAL14_MOUSE NM_001002894 Nalp14 Q66X14 Q6B966 uc009jax.1 uc009jax.2 uc009jax.3 uc009jax.4 May be involved in inflammation and spermatogenesis. Cytoplasm Detected in adult ovary and testis. Detected in oocytes and in germ cell elements in seminiferous tubules in adult testis (at protein level). Not detected in ovaries from neonates. First detected in ovaries three days after birth, and expression in ovaries increases dramatically to reach a much higher level eight days after birth. Belongs to the NLRP family. Sequence=AAT77542.1; Type=Erroneous initiation; Evidence=; nucleotide binding molecular_function ATP binding cellular_component cytoplasm multicellular organism development spermatogenesis cell differentiation uc009jax.1 uc009jax.2 uc009jax.3 uc009jax.4 
ENSMUST00000084770.5 Fut9 ENSMUST00000084770.5 fucosyltransferase 9 (from RefSeq NM_010243.3) ENSMUST00000084770.1 ENSMUST00000084770.2 ENSMUST00000084770.3 ENSMUST00000084770.4 Fut9 NM_010243 Q14AE3 Q14AE3_MOUSE uc008sei.1 uc008sei.2 uc008sei.3 Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L- fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+); Xref=Rhea:RHEA:14257, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133507, ChEBI:CHEBI:137941; EC=2.4.1.152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14258; Evidence=; Reaction=a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+); Xref=Rhea:RHEA:48376, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90376, ChEBI:CHEBI:90379; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48377; Evidence=; Reaction=alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl- beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1')-ceramide + GDP-beta-L-fucose = a neolactoside IV(3)-alpha- Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+); Xref=Rhea:RHEA:48380, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90380, ChEBI:CHEBI:90381; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48381; Evidence=; Reaction=alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)- N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N- acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D- glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = alpha-N- glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta- D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl- (1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)- beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+); Xref=Rhea:RHEA:48388, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90383, ChEBI:CHEBI:90384; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48389; Evidence=; Reaction=an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)- beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D- Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:68044, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:145343, ChEBI:CHEBI:176900; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68045; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 10 family. Golgi apparatus protein glycosylation nervous system development fucosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups Golgi cisterna membrane fucosylation uc008sei.1 uc008sei.2 uc008sei.3 
ENSMUST00000084787.6 Scn10a ENSMUST00000084787.6 sodium channel, voltage-gated, type X, alpha, transcript variant 1 (from RefSeq NM_001205321.1) ENSMUST00000084787.1 ENSMUST00000084787.2 ENSMUST00000084787.3 ENSMUST00000084787.4 ENSMUST00000084787.5 K3W4P8 K3W4P8_MOUSE NM_001205321 Scn10a uc009sbh.1 uc009sbh.2 uc009sbh.3 uc009sbh.4 Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Tetrodotoxin-resistant channel that mediates the voltage- dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. Reaction=Na(+)(in) = Na(+)(out); Xref=Rhea:RHEA:34963, ChEBI:CHEBI:29101; Evidence=; Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. voltage-gated sodium channel complex regulation of heart rate ion channel activity voltage-gated ion channel activity voltage-gated sodium channel activity sodium channel activity plasma membrane ion transport sodium ion transport membrane integral component of membrane sensory perception of pain regulation of ion transmembrane transport sodium ion transmembrane transport odontogenesis of dentin-containing tooth ion channel binding transmembrane transport regulation of cardiac muscle contraction regulation of atrial cardiac muscle cell membrane depolarization clathrin complex AV node cell action potential bundle of His cell action potential glutamatergic synapse integral component of presynaptic membrane uc009sbh.1 uc009sbh.2 uc009sbh.3 uc009sbh.4 
ENSMUST00000084797.6 Slc22a13 ENSMUST00000084797.6 solute carrier family 22 (organic cation transporter), member 13 (from RefSeq NM_133980.3) E9QP74 ENSMUST00000084797.1 ENSMUST00000084797.2 ENSMUST00000084797.3 ENSMUST00000084797.4 ENSMUST00000084797.5 NM_133980 Orctl3 Q6A4L0 Q8VC89 S22AD_MOUSE Slc22a13 uc009sal.1 uc009sal.2 uc009sal.3 uc009sal.4 uc009sal.5 Anion antiporter that mediates the transport of orotate and nicotinate in exchange for organic or inorganic anions (PubMed:35144162). Translocates orotate across the apical membrane of proximal tubule epithelial cells. Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption (PubMed:35144162). Orotate transport is Cl(-)-dependent (By similarity). Reaction=a carboxylate(out) + nicotinate(in) = a carboxylate(in) + nicotinate(out); Xref=Rhea:RHEA:74371, ChEBI:CHEBI:29067, ChEBI:CHEBI:32544; Evidence=; Reaction=a carboxylate(in) + orotate(out) = a carboxylate(out) + orotate(in); Xref=Rhea:RHEA:73487, ChEBI:CHEBI:29067, ChEBI:CHEBI:30839; Evidence=; Apical cell membrane ; Multi-pass membrane protein Glycosylated. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. In contrast with human ortholog, not able to transport urate (PubMed:35144162). urate transport membrane integral component of membrane apical plasma membrane transmembrane transporter activity transmembrane transport nicotinate transporter activity nicotinate transport uc009sal.1 uc009sal.2 uc009sal.3 uc009sal.4 uc009sal.5 
ENSMUST00000084806.7 Dnah11 ENSMUST00000084806.7 dynein, axonemal, heavy chain 11 (from RefSeq NM_010060.3) Dnah11 Dnahc11 E9Q7N9 E9Q7N9_MOUSE ENSMUST00000084806.1 ENSMUST00000084806.2 ENSMUST00000084806.3 ENSMUST00000084806.4 ENSMUST00000084806.5 ENSMUST00000084806.6 NM_010060 uc007pie.1 uc007pie.2 Belongs to the dynein heavy chain family. cardiac septum development cilium movement epithelial cilium movement regulation of cilium beat frequency microtubule motor activity ATP binding extracellular region axoneme microtubule-based movement determination of left/right symmetry heart development learning or memory ATP-dependent microtubule motor activity, minus-end-directed dynein complex flagellated sperm motility motile cilium determination of left/right asymmetry in nervous system dynein intermediate chain binding dynein light intermediate chain binding epithelial cilium movement involved in determination of left/right asymmetry cardiac septum morphogenesis determination of heart left/right asymmetry 9+0 motile cilium 9+2 motile cilium sperm flagellum movement involved in flagellated sperm motility uc007pie.1 uc007pie.2 
ENSMUST00000084820.6 Golga4 ENSMUST00000084820.6 golgin A4, transcript variant 1 (from RefSeq NM_018748.4) ENSMUST00000084820.1 ENSMUST00000084820.2 ENSMUST00000084820.3 ENSMUST00000084820.4 ENSMUST00000084820.5 GOGA4_MOUSE NM_018748 O70365 Q8CGH6 Q91VW5 uc009rzu.1 uc009rzu.2 uc009rzu.3 Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking. Homodimer. Interacts with GTP-bound ARL1 and ARL3 (By similarity). Interacts with MACF1 (By similarity). Directly interacts with TBC1D23 (PubMed:29084197). Interacts with FAM91A1; this interaction may be mediated by TBC1D23 (By similarity). Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein Golgi apparatus, trans-Golgi network membrane Ubiquitous. Highly expressed in oligodendrocyte precursors, particularly at a stage just prior to myelination. Extended rod-like protein with coiled-coil domains. Sequence=AAH37641.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi membrane cytoplasm Golgi apparatus cytosol membrane Golgi to plasma membrane protein transport intracellular membrane-bounded organelle positive regulation of axon extension GTPase binding uc009rzu.1 uc009rzu.2 uc009rzu.3 
ENSMUST00000084828.5 Ncapg2 ENSMUST00000084828.5 non-SMC condensin II complex, subunit G2 (from RefSeq NM_133762.4) CNDG2_MOUSE E9QP71 ENSMUST00000084828.1 ENSMUST00000084828.2 ENSMUST00000084828.3 ENSMUST00000084828.4 Luzp5 Mtb NM_133762 Q6DFV1 Q6SLL0 Q922D1 uc007pht.1 uc007pht.2 uc007pht.3 Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Is required for early embryonic development and is essential for viability and expansion of the inner cell mass (ICM) of the implanting blastocyst. Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2. Nucleus Expressed in spleen, lung and testis as well as in hematopoietic cell lines. Expressed from 7 dpc when yolk sac hematopoiesis is initiated. Between 12.5 dpc and 15.5 dpc restricted to the developing fetal liver and the site of definitive hematopoiesis. Detected in thymus at 15.5 dpc as well as the midbrain, forebrain and the olfactory epithelium. Sequence=AAH08539.1; Type=Frameshift; Evidence=; condensin complex inner cell mass cell proliferation protein binding nucleus transcription from RNA polymerase II promoter cell cycle nuclear speck erythrocyte differentiation chromosome condensation methylated histone binding bHLH transcription factor binding negative regulation of erythrocyte differentiation cell division positive regulation of protein tyrosine kinase activity molecular function regulator positive regulation of receptor activity uc007pht.1 uc007pht.2 uc007pht.3 
ENSMUST00000084830.2 Chrna10 ENSMUST00000084830.2 cholinergic receptor, nicotinic, alpha polypeptide 10 (from RefSeq NM_001081424.1) B2RX82 B2RX82_MOUSE Chrna10 ENSMUST00000084830.1 NM_001081424 uc009iqw.1 uc009iqw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity protein binding plasma membrane integral component of plasma membrane ion transport signal transduction positive regulation of cytosolic calcium ion concentration chemical synaptic transmission synaptic transmission, cholinergic membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction axon ion transmembrane transport regulation of membrane potential inner ear morphogenesis neuron projection perikaryon synapse postsynaptic membrane neurological system process detection of mechanical stimulus involved in sensory perception of sound regulation of postsynaptic membrane potential excitatory postsynaptic potential negative regulation of ERK1 and ERK2 cascade cholinergic synapse integral component of postsynaptic specialization membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc009iqw.1 uc009iqw.2 
ENSMUST00000084843.10 Xntrpc ENSMUST00000084843.10 Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough, transcript variant Xndr-Trpc2 protein (from RefSeq NM_011644.3) ENSMUST00000084843.1 ENSMUST00000084843.2 ENSMUST00000084843.3 ENSMUST00000084843.4 ENSMUST00000084843.5 ENSMUST00000084843.6 ENSMUST00000084843.7 ENSMUST00000084843.8 ENSMUST00000084843.9 F8VQM8 F8VQM8_MOUSE NM_011644 Xntrpc uc291tkp.1 uc291tkp.2 This locus represents naturally occurring readthrough transcription between the neighboring Xndr (XRCC1 N-terminal domain-related) and Trpc2 (transient receptor potential cation channel, subfamily C, member 2) genes on chromosome 7. Readthrough transcripts include one that encodes a fusion protein that shares sequence identity with each individual gene product and one that is a candidate for nonsense-mediated mRNA decay (NMD), and thus is unlikely to produce a protein product. [provided by RefSeq, Nov 2013]. Membrane ; Multi- pass membrane protein single strand break repair damaged DNA binding ion channel activity calcium channel activity nucleus integral component of plasma membrane ion transport manganese ion transport single fertilization store-operated calcium channel activity membrane integral component of membrane cation channel complex regulation of cytosolic calcium ion concentration transmembrane transport calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding uc291tkp.1 uc291tkp.2 
ENSMUST00000084846.12 Srrm1 ENSMUST00000084846.12 serine/arginine repetitive matrix 1, transcript variant 5 (from RefSeq NM_001369069.1) A2A8V9 A2A8V9_MOUSE ENSMUST00000084846.1 ENSMUST00000084846.10 ENSMUST00000084846.11 ENSMUST00000084846.2 ENSMUST00000084846.3 ENSMUST00000084846.4 ENSMUST00000084846.5 ENSMUST00000084846.6 ENSMUST00000084846.7 ENSMUST00000084846.8 ENSMUST00000084846.9 NM_001369069 Srrm1 uc008vge.1 uc008vge.2 uc008vge.3 uc008vge.4 mRNA processing uc008vge.1 uc008vge.2 uc008vge.3 uc008vge.4 
ENSMUST00000084852.13 Numa1 ENSMUST00000084852.13 nuclear mitotic apparatus protein 1, transcript variant 9 (from RefSeq NM_133947.4) E9Q7G0 ENSMUST00000084852.1 ENSMUST00000084852.10 ENSMUST00000084852.11 ENSMUST00000084852.12 ENSMUST00000084852.2 ENSMUST00000084852.3 ENSMUST00000084852.4 ENSMUST00000084852.5 ENSMUST00000084852.6 ENSMUST00000084852.7 ENSMUST00000084852.8 ENSMUST00000084852.9 NM_133947 NUMA1_MOUSE Numa1 Q80Y35 uc009iqb.1 uc009iqb.2 uc009iqb.3 Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:19255246, PubMed:24109598, PubMed:26765568). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:26765568). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:24109598, PubMed:26765568). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation. Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (By similarity). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:26765568). Plays a role in mitotic MT aster assembly. Involved in anastral spindle assembly. Positively regulates TNKS protein localization to spindle poles in mitosis. Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (By similarity). Required for epidermal differentiation and hair follicle morphogenesis (PubMed:26765568). Homodimer. Also forms multiarm oligomers by association of C- terminal tail domains, oligomers may further assemble to form a hexagonal nuclear lattice-like network. Associates with the dynein- dynactin complex; this association promotes the transport and accumulation of NUMA1 at the mitotic spindle poles that is inhibited by the BRISC complex in a PLK1-dependent manner. Part of a spindle orientation complex at least composed of GNAI1, GPSM2 and NUMA1 (By similarity). Interacts (via C-terminus) with microtubules (MTs); this interaction is direct and promotes both MT bundle formation and stability in a dynein-dynactin complex- and CDK1-independent manner. Interacts with EPB41 and EPB41L2; these interactions are negatively regulated by CDK1 during metaphase and are important for anaphase- specific localization of NUMA1 in symmetrically dividing cells. Interacts (via C-terminus) with GPSM2 (via TPR repeats); this interaction is direct, prevented by competitive binding of INSC, is inhibited in a PLK1-dependent manner, blocks the association of NUMA1 with MTs and inhibits NUMA1-induced MT bundle formation, prevents the association of NUMA1 with SPAG5, induces mitotic spindle pole localization of GPSM2, both metaphase cell cortex localization of NUMA1 and mitotic spindle organization. Does not interact with GPSM2 during anaphase. Interacts (via C-terminus) with the nuclear importin alpha/importin beta receptor; this interaction is inhibited by RanGTP. Interacts (via C-terminus) with KPNB1; this interaction is inhibited by RanGTP and the BRISC complex. Interacts with ABRAXAS2 and the BRISC complex; these interactions regulate mitotic spindle assembly. Interacts (via N-terminal end of the coiled-coil domain) with RAE1; this interaction promotes mitotic spindle formation. Interacts (via C- terminus) with SPAG5 (via C-terminus); this interaction promotes the recruitment of SPAG5 to the MTs at spindle poles in a dynein-dynactin- dependent manner and regulates mitotic spindle organization and proper chromosome alignment during mitosis. Interacts with TNKS; this interaction occurs at the onset of mitosis. Interacts with TNKS2. Interacts with tubulin. Interacts with KHDC3 (via C-terminus) (PubMed:25936915). Nucleus Nucleus, nucleoplasm Nucleus matrix Chromosome Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole toplasm, cell cortex ll membrane ; Lipid-anchor ; Cytoplasmic side Lateral cell membrane Note=Mitotic cell cycle-dependent shuttling protein that relocalizes from the interphase nucleus to the spindle poles and cell cortex (PubMed:19255246, PubMed:24109598, PubMed:26765568). The localization to the spindle poles is regulated by AAAS (By similarity). In interphase, resides in the nuclear matrix (PubMed:19255246). In prophase, restricted to the interchromatin or condensed chromosome space. In prometaphase, after nuclear envelope disassembly, forms aggregates both in the spindle midzone and at duplicated centrosomes and astral microtubules (MTs) of the bipolar spindle apparatus. Translocates from the spindle midzone towards the spindle poles along spindle fibers in a MT- and dynein-dynactin- dependent manner until the anaphase onset (By similarity). In metaphase, recruited to the polar cortical region in a GPSM2- and GNAI1-dependent manner (PubMed:24109598). Excluded from the metaphase equatorial cortical region in a RanGTP-dependent manner. Phosphorylation on Thr-2037 by CDK1 results in its localization at spindle poles in metaphase, but not at the cell cortex (By similarity). In anaphase, recruited and anchored at the cell membrane of the polar cortical region in a EPB41-, EPB41L2-, phosphatidylinositol-dependent and GPSM2- and G(i) alpha proteins-independent manner (PubMed:24109598). Excluded from the anaphase equatorial region of the cell cortex in a RACGAP1- and KIF23-dependent and RanGTP-independent manner. Associated with astral MTs emanating from the spindle poles during anaphase. Nonphosphorylated Thr-2037 localizes at the cell cortex, weakly during metaphase and more prominently during anaphase in a phosphatase PPP2CA-dependent manner. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident. Localizes to the tips of cortical MTs in prometaphase (By similarity). Localizes along MTs and specifically to both MT plus and minus ends (PubMed:26765568). Accumulates also at MT tips near the cell periphery. Colocalizes with GPSM2 at mitotic spindle poles during mitosis. Colocalizes with SPAG5 at mitotic spindle at prometaphase and at mitotic spindle poles at metaphase and anaphase. Colocalizes with ABRO1 at mitotic spindle poles. Colocalized with TNKS from prophase through to anaphase in mitosis. Colocalizes with tubulin alpha. CCSAP is essential for its centrosomal localization (By similarity). In horizontally retinal progenitor dividing cells, localized to the lateral cortical region (PubMed:26766442). Expressed in testis, speen, liver, lung, spinal cord and brain. Expressed in Purkinje neurons (at protein level) (PubMed:19255246). The C-terminal tubulin-binding domain mediates direct binding to microtubules, independently of dynein-dynactin complex, and induces their bundling and stabilization. The 4.1-binding domain is necessary for its cortical stability and spindle orientation. Phosphorylation and dephosphorylation on Thr-2037 regulates the extent of cortical NUMA1 and the dynein-dynactin complex localization during mitotic metaphase and anaphase. In metaphase, phosphorylation on Thr-2037 occurs in a kinase CDK1-dependent manner; this phosphorylation maintains low levels of cortical dynein-dynactin complex at metaphase, and hence proper spindle positioning. In anaphase, dephosphorylated on Thr-2037 by phosphatase PPP2CA; this dephosphorylation stimulates its membrane association and with the dynein-dynactin complex its enrichment at the cell cortex, and hence robust spindle elongation. Probably also phosphorylated on Thr-1997 and Ser-2069 by CDK1; these phosphorylations may regulate its cell cortex recruitment during metaphase and anaphase. Phosphorylated on Ser-1751, Ser-1754, Ser-1771 and Ser-1816 by PLK1; these phosphorylations induce cortical dynein- dynactin complex dissociation from the NUMA1-GPSM2 complex and negatively regulates cortical dynein-dynactin complex localization. ADP-ribosylated by TNKS at the onset of mitosis; ADP-ribosylation is not required for its localization to spindle poles. O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status. Ubiquitinated with 'Lys-63'-linked polyubiquitin chains. Deubiquitination by the BRISC complex is important for the incorporation of NUMA1 into mitotic spindle poles and normal spindle pole function, probably by modulating interactions between NUMA1, dynein-dynactin complex and importin-beta. Mutant mice with an internal in-frame deletion of exon 22 exhibit early embryonic lethality (PubMed:19255246). Mutant mice with a conditional internal in-frame deletion of exon 22 show embryonic lethality and display inhibition of primary embryonic fibroblast proliferation that display mitotic centrosome-spindle coupling, microtubule-focusing at the spindle poles and equatorial metaphase chromosome alignement defects (PubMed:19255246). Mutant mice with a conditional internal in-frame deletion of exon 22 in the embryonic epidermis show neonatal lethality and display perturbation of epidermis differentiation characterized by increased suprabasal cell divisions and mitotic spindle orientation defects (PubMed:26765568). Adult mutant mice with a conditional internal in-frame deletion of exon 22 in interfollicular and hair follicles display an almost complete absence of hair regrowth and mitotic spindle orientation defects in hair follicle matrix cells (PubMed:26765568). establishment of mitotic spindle orientation Golgi membrane spindle pole microtubule bundle formation nucleus nucleoplasm chromosome cytoplasm centrosome microtubule organizing center cytosol cytoskeleton microtubule spindle microtubule plasma membrane cell cortex cell cycle chromosome segregation microtubule binding protein C-terminus binding lipid binding tubulin binding membrane lateral plasma membrane nuclear matrix extrinsic component of plasma membrane protein domain specific binding dendrite positive regulation of BMP signaling pathway astral microtubule organization positive regulation of microtubule polymerization spindle pole centrosome positive regulation of intracellular transport macromolecular complex phosphatidylinositol binding microtubule plus-end microtubule minus-end neuronal cell body macromolecular complex binding positive regulation of keratinocyte differentiation microtubule plus-end binding microtubule minus-end binding cell division meiotic cell cycle positive regulation of hair follicle development positive regulation of chromosome segregation cortical microtubule anastral spindle assembly regulation of mitotic spindle organization mitotic spindle astral microtubule dynein complex binding mitotic spindle regulation of metaphase plate congression microtubule bundle mitotic spindle pole lateral cell cortex disordered domain specific binding cell cortex region positive regulation of protein localization to spindle pole body positive regulation of mitotic spindle elongation positive regulation of protein localization to cell cortex cytoplasmic microtubule bundle mitotic spindle midzone uc009iqb.1 uc009iqb.2 uc009iqb.3 
ENSMUST00000084881.5 Crtap ENSMUST00000084881.5 cartilage associated protein (from RefSeq NM_019922.3) CRTAP_MOUSE Casp ENSMUST00000084881.1 ENSMUST00000084881.2 ENSMUST00000084881.3 ENSMUST00000084881.4 NM_019922 O88698 Q8C8C5 Q9CYD3 uc009rxg.1 uc009rxg.2 uc009rxg.3 uc009rxg.4 Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. Secreted, extracellular space, extracellular matrix. Found in articular chondrocytes. Expressed in a variety of tissues. Note=Defects in Crtap are a cause of osteochondrodysplasia characterized by severe osteoporosis and decreased osteoid production. Belongs to the leprecan family. protein binding extracellular region extracellular space endoplasmic reticulum spermatogenesis peptidyl-proline hydroxylation to 3-hydroxy-L-proline macromolecular complex protein stabilization chaperone-mediated protein folding negative regulation of post-translational protein modification uc009rxg.1 uc009rxg.2 uc009rxg.3 uc009rxg.4 
ENSMUST00000084882.9 Crip2 ENSMUST00000084882.9 cysteine rich protein 2, transcript variant 1 (from RefSeq NM_024223.2) CRIP2_MOUSE Crp2 ENSMUST00000084882.1 ENSMUST00000084882.2 ENSMUST00000084882.3 ENSMUST00000084882.4 ENSMUST00000084882.5 ENSMUST00000084882.6 ENSMUST00000084882.7 ENSMUST00000084882.8 Hlp NM_024223 Q9DCT8 uc007pfy.1 uc007pfy.2 uc007pfy.3 uc007pfy.4 uc007pfy.5 Interacts with TGFB1I1. In the embryo, its expression is primarily restricted to the developing heart. In situ hybridization showed expression at 7.75 dpc in the paired heart-forming primordia prior to linear heart-tube formation. At 8.5 dpc, strong expression is detected in the heart, with equal expression in both heart chambers. Expression is detected in both myocardium and endocardium, and in vascular endothelium. Later in fetal development low levels of expression is detected outside the heart, including dorsal root ganglia and the spinal cord. In the adult, it is expressed at highest levels in the heart, and at lower levels in the brain, skeletal muscle and aorta. protein binding cell cortex positive regulation of cell proliferation hemopoiesis metal ion binding uc007pfy.1 uc007pfy.2 uc007pfy.3 uc007pfy.4 uc007pfy.5 
ENSMUST00000084885.12 Ubp1 ENSMUST00000084885.12 upstream binding protein 1, transcript variant 9 (from RefSeq NR_164181.1) A4QPG4 Cp2b ENSMUST00000084885.1 ENSMUST00000084885.10 ENSMUST00000084885.11 ENSMUST00000084885.2 ENSMUST00000084885.3 ENSMUST00000084885.4 ENSMUST00000084885.5 ENSMUST00000084885.6 ENSMUST00000084885.7 ENSMUST00000084885.8 ENSMUST00000084885.9 NR_164181 Nf2d9 Q3UPR3 Q3US11 Q60786 Q811S7 Q8C514 UBIP1_MOUSE uc009rwx.1 uc009rwx.2 uc009rwx.3 uc009rwx.4 Functions as a transcriptional activator in a promoter context-dependent manner. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Functions as a trans-acting factor that regulates the domestic strain CYP2D9 gene through specific association with the regulatory element SDI-A1. Binding to SDI-A1 depends on the type of nucleotide at position 299; binding is abolished by a nucleotide substitution at this position. Modulates the placental expression of CYP11A1 (By similarity). Interacts with TFCP2 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CP2b; IsoId=Q811S7-1; Sequence=Displayed; Name=2; Synonyms=CP2a; IsoId=Q811S7-2; Sequence=VSP_017731; Ubiquitous. Highly expressed in erythroid cells. Present in both domestic and wild mouse strains. Recognizes the genetic difference at position 299 in the SDI-A1 element. Belongs to the grh/CP2 family. CP2 subfamily. angiogenesis DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding uc009rwx.1 uc009rwx.2 uc009rwx.3 uc009rwx.4 
ENSMUST00000084891.5 Pacs2 ENSMUST00000084891.5 phosphofurin acidic cluster sorting protein 2, transcript variant 2 (from RefSeq NM_001081170.1) E9Q7E9 E9Q7E9_MOUSE ENSMUST00000084891.1 ENSMUST00000084891.2 ENSMUST00000084891.3 ENSMUST00000084891.4 NM_001081170 Pacs2 uc007pfr.1 uc007pfr.2 Belongs to the PACS family. autophagosome assembly mitochondrion endoplasmic reticulum protein localization to pre-autophagosomal structure protein localization to plasma membrane uc007pfr.1 uc007pfr.2 
ENSMUST00000084892.12 Dpy19l4 ENSMUST00000084892.12 dpy-19 like 4 (from RefSeq NM_001081201.2) A2AJQ3 B2RW18 D19L4_MOUSE ENSMUST00000084892.1 ENSMUST00000084892.10 ENSMUST00000084892.11 ENSMUST00000084892.2 ENSMUST00000084892.3 ENSMUST00000084892.4 ENSMUST00000084892.5 ENSMUST00000084892.6 ENSMUST00000084892.7 ENSMUST00000084892.8 ENSMUST00000084892.9 Gm1023 NM_001081201 Q3T9A8 uc008rzi.1 uc008rzi.2 uc008rzi.3 Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AJQ3-1; Sequence=Displayed; Name=2; IsoId=A2AJQ3-2; Sequence=VSP_029632; Belongs to the dpy-19 family. mannosyltransferase activity nuclear inner membrane membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan uc008rzi.1 uc008rzi.2 uc008rzi.3 
ENSMUST00000084894.15 Gm45837 ENSMUST00000084894.15 phosphodiesterase 2A, cGMP-stimulated, transcript variant 11 (from RefSeq NM_001420546.1) ENSMUST00000084894.1 ENSMUST00000084894.10 ENSMUST00000084894.11 ENSMUST00000084894.12 ENSMUST00000084894.13 ENSMUST00000084894.14 ENSMUST00000084894.2 ENSMUST00000084894.3 ENSMUST00000084894.4 ENSMUST00000084894.5 ENSMUST00000084894.6 ENSMUST00000084894.7 ENSMUST00000084894.8 ENSMUST00000084894.9 F7D3W5 F7D3W5_MOUSE Gm45837 NM_001420546 uc291thi.1 uc291thi.2 Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Belongs to the cyclic nucleotide phosphodiesterase family. 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity nucleus mitochondrial outer membrane mitochondrial inner membrane mitochondrial matrix cytosol signal transduction phosphoric diester hydrolase activity positive regulation of gene expression negative regulation of cGMP-mediated signaling regulation of mitochondrion organization hydrolase activity cAMP-mediated signaling cGMP-mediated signaling protein homodimerization activity negative regulation of cAMP-mediated signaling cGMP catabolic process metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity perinuclear region of cytoplasm plasma membrane uc291thi.1 uc291thi.2 
ENSMUST00000084896.10 Arap1 ENSMUST00000084896.10 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1, transcript variant 6 (from RefSeq NM_001407803.1) ARAP1_MOUSE Arap1 B2RUJ3 Centd2 ENSMUST00000084896.1 ENSMUST00000084896.2 ENSMUST00000084896.3 ENSMUST00000084896.4 ENSMUST00000084896.5 ENSMUST00000084896.6 ENSMUST00000084896.7 ENSMUST00000084896.8 ENSMUST00000084896.9 Kiaa0782 NM_001407803 Q3UDD2 Q3US99 Q4LDD4 Q58ET6 Q6PEQ9 Q6ZQ48 uc009iol.1 uc009iol.2 uc009iol.3 Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase- activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). Interacts with TNFRSF10A. Cytoplasm Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein Cell membrane Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q4LDD4-1; Sequence=Displayed; Name=2 ; IsoId=Q4LDD4-2; Sequence=VSP_053048; Name=3 ; IsoId=Q4LDD4-3; Sequence=VSP_053047, VSP_053048; positive regulation of receptor recycling transcription factor activity, sequence-specific DNA binding GTPase activator activity phosphatidylinositol-3,4,5-trisphosphate binding nucleoplasm cytoplasm Golgi apparatus trans-Golgi network cytosol plasma membrane signal transduction transforming growth factor beta receptor signaling pathway transcription factor binding regulation of cell shape membrane cytoplasmic vesicle type 1 angiotensin receptor binding Golgi cisterna membrane intracellular membrane-bounded organelle positive regulation of GTPase activity transcription regulatory region DNA binding positive regulation of transcription, DNA-templated metal ion binding regulation of cellular component movement positive regulation of filopodium assembly negative regulation of stress fiber assembly SMAD protein signal transduction R-SMAD binding uc009iol.1 uc009iol.2 uc009iol.3 
ENSMUST00000084926.9 Als2cl ENSMUST00000084926.9 ALS2 C-terminal like, transcript variant 4 (from RefSeq NR_153354.1) A0A0R4J1X4 A0A0R4J1X4_MOUSE Als2cl ENSMUST00000084926.1 ENSMUST00000084926.2 ENSMUST00000084926.3 ENSMUST00000084926.4 ENSMUST00000084926.5 ENSMUST00000084926.6 ENSMUST00000084926.7 ENSMUST00000084926.8 NR_153354 uc009rvc.1 uc009rvc.2 uc009rvc.3 uc009rvc.4 endosome organization identical protein binding uc009rvc.1 uc009rvc.2 uc009rvc.3 uc009rvc.4 
ENSMUST00000084935.11 Pgm2l1 ENSMUST00000084935.11 phosphoglucomutase 2-like 1 (from RefSeq NM_027629.3) ENSMUST00000084935.1 ENSMUST00000084935.10 ENSMUST00000084935.2 ENSMUST00000084935.3 ENSMUST00000084935.4 ENSMUST00000084935.5 ENSMUST00000084935.6 ENSMUST00000084935.7 ENSMUST00000084935.8 ENSMUST00000084935.9 NM_027629 PGM2L_MOUSE Pgm2l1 Q8CAA7 uc012fqa.1 uc012fqa.2 uc012fqa.3 Glucose 1,6-bisphosphate synthase using 1,3- bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars, including glucose 1-phosphate, mannose 1-phosphate, ribose 1- phosphate and deoxyribose 1-phosphate, as acceptors. In vitro, also exhibits very low phosphopentomutase and phosphoglucomutase activity which are most probably not physiologically relevant. Reaction=(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1- phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6- bisphosphate + H(+); Xref=Rhea:RHEA:16769, ChEBI:CHEBI:15378, ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:58392, ChEBI:CHEBI:58601; EC=2.7.1.106; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16770; Evidence=; Reaction=(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6- phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6- bisphosphate + H(+); Xref=Rhea:RHEA:70911, ChEBI:CHEBI:15378, ChEBI:CHEBI:57604, ChEBI:CHEBI:58225, ChEBI:CHEBI:58272, ChEBI:CHEBI:58392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70912; Evidence=; Reaction=(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1- phosphate = (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+); Xref=Rhea:RHEA:70899, ChEBI:CHEBI:15378, ChEBI:CHEBI:57604, ChEBI:CHEBI:57720, ChEBI:CHEBI:58272, ChEBI:CHEBI:68688; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70900; Evidence=; Reaction=(2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1- phosphate = (2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5- bisphosphate + H(+); Xref=Rhea:RHEA:70903, ChEBI:CHEBI:15378, ChEBI:CHEBI:57259, ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:190126; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70904; Evidence=; Reaction=(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1- phosphate = (2R)-3-phosphoglycerate + alpha-D-mannose 1,6- bisphosphate + H(+); Xref=Rhea:RHEA:70907, ChEBI:CHEBI:15378, ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:58409, ChEBI:CHEBI:190127; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70908; Evidence=; Cytoplasm, cytosol Expressed at highest levels in the brain and testis, at intermediate levels in thymus, spleen, lung and skeletal muscle, and at lowest levels in kidney, liver and heart. Belongs to the phosphohexose mutase family. carbohydrate metabolic process glucose metabolic process phosphorylation transferase activity isomerase activity intramolecular transferase activity, phosphotransferases metal ion binding glucose-1,6-bisphosphate synthase activity organic substance metabolic process uc012fqa.1 uc012fqa.2 uc012fqa.3 
ENSMUST00000084949.3 Bpnt2 ENSMUST00000084949.3 3'(2'), 5'-bisphosphate nucleotidase 2 (from RefSeq NM_177730.4) A6H6P6 Bpnt2 ENSMUST00000084949.1 ENSMUST00000084949.2 IMPA3_MOUSE Impa3 Impad1 NM_177730 Q80V26 uc008rxc.1 uc008rxc.2 uc008rxc.3 uc008rxc.4 uc008rxc.5 Exhibits 3'-nucleotidase activity toward adenosine 3',5'- bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate (PubMed:18695242). May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'- bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (PubMed:18695242). Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4. Reaction=adenosine 3',5'-bisphosphate + H2O = AMP + phosphate; Xref=Rhea:RHEA:10040, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58343, ChEBI:CHEBI:456215; EC=3.1.3.7; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Strongly inhibited by lithium. Kinetic parameters: KM=21 uM for 3'-phosphoadenosine 5'- phosphate (PAP) ; Vmax=9.5 umol/min/mg enzyme ; Sulfur metabolism. Golgi apparatus Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein Note=The catalytic core is predicted to reside within the Golgi lumen. At 18.5 dpc, widely expressed with enhanced levels in brain, spinal cord, lung and kidney, including medulla and cortex. In the developing brain, strongly expressed in the neopallial cortex and throughout the cerebellum with intense expression within the developing Purkinje cells and adjacent choroid plexus. Strong expression also observed within the pons and throughout the medulla oblongata. In the lung, expressed in individual pneumocytes and particularly in cells surrounding developing bronchi/bronchioles. Moderate expression in chondrocytes of costal cartilage and in the surrounding perichondrium. N-glycosylated (By similarity). Contains N-linked glycan resistant to endoglycosydase H (By similarity). Mutant animals experience severe respiratory distress and died within minutes after birth. At 18.5 dpc, lungs exhibit small alveolar spaces and thickened septa. The rib cage cartilage is hypocellular with abnormal, fibrous-appearing extracellular matrix. Animals show severe skeletal abnormalities, most notably in the longitudinal growth of bones formed by endochondral ossification. The length of the axial skeleton is reduced. The appendicular bones of the upper limbs, as well as the ilium, femur, tibia and fibula of the lower limbs are markedly shorter than in wild- type littermates. The rib cages display malformation characterized by reduced sternal length and correspondingly diminished rib spacing. The process of intramembranous ossification is normal. Mutant animals exhibit a deficiency in glycosaminoglycan sulfation. Mutant cartilage and lung exhibit a substantial decrease in chondroitin 4-sulfate and an increase in nonsulfated chondroitin compared with wild type tissue. Belongs to the inositol monophosphatase superfamily. skeletal system development endochondral ossification chondrocyte development nucleus Golgi apparatus cytosol inositol biosynthetic process 3'-nucleotidase activity 3'(2'),5'-bisphosphate nucleotidase activity inositol monophosphate 1-phosphatase activity post-embryonic development membrane integral component of membrane dephosphorylation nuclear body hydrolase activity chondroitin sulfate metabolic process embryonic digit morphogenesis phosphatidylinositol phosphorylation metal ion binding inositol monophosphate 3-phosphatase activity inositol monophosphate 4-phosphatase activity inositol monophosphate phosphatase activity uc008rxc.1 uc008rxc.2 uc008rxc.3 uc008rxc.4 uc008rxc.5 
ENSMUST00000084952.8 Kif9 ENSMUST00000084952.8 kinesin family member 9, transcript variant 2 (from RefSeq NM_010628.4) E9QMT7 ENSMUST00000084952.1 ENSMUST00000084952.2 ENSMUST00000084952.3 ENSMUST00000084952.4 ENSMUST00000084952.5 ENSMUST00000084952.6 ENSMUST00000084952.7 KIF9_MOUSE NM_010628 O35070 Q9WV04 uc009rud.1 uc009rud.2 uc009rud.3 uc009rud.4 Essential for normal male fertility and for progressive motility of spermatozoa. Interacts with HYDIN. Cytoplasm, cytoskeleton Cell projection, cilium, flagellum Cytoplasm, cytoskeleton, flagellum axoneme Highly expressed in the testis (at protein level) (PubMed:32072696). Weakly expressed in the brain, thymus, lung and heart (PubMed:32072696). Mice exhibit impaired sperm motility and male subfertility and flagella show an asymmetric waveform pattern, which leads to a circular motion of spermatozoa. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding podosome microtubule motor activity ATP binding cytoplasm cytosol cytoskeleton kinesin complex microtubule microtubule-based movement microtubule binding ATPase activity extracellular matrix disassembly vesicle protein dimerization activity regulation of podosome assembly organelle disassembly uc009rud.1 uc009rud.2 uc009rud.3 uc009rud.4 
ENSMUST00000084953.13 Mark3 ENSMUST00000084953.13 MAP/microtubule affinity regulating kinase 3, transcript variant 1 (from RefSeq NM_021516.4) ENSMUST00000084953.1 ENSMUST00000084953.10 ENSMUST00000084953.11 ENSMUST00000084953.12 ENSMUST00000084953.2 ENSMUST00000084953.3 ENSMUST00000084953.4 ENSMUST00000084953.5 ENSMUST00000084953.6 ENSMUST00000084953.7 ENSMUST00000084953.8 ENSMUST00000084953.9 Emk2 MARK3_MOUSE Mpk10 NM_021516 Q03141 Q3TM40 Q3V1U3 Q8C6G9 Q8R375 Q9JKE4 uc007pdk.1 uc007pdk.2 uc007pdk.3 uc007pdk.4 Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564 (By similarity). Interacts with MAPT/TAU (By similarity). Interacts with DLG5 (via coiled-coil domain) (By similarity). Interacts with STK3/MST2 and STK4/MST1 in the presence of DLG5 (By similarity). Interacts with YWHAB, YWHAG, YWHAQ and YWHAZ (By similarity). Interacts with PKP2 (via N-terminus) (By similarity). Interacts with CDC25C (By similarity). Interacts with KSR1 (PubMed:12941695). Cell membrane ; Peripheral membrane protein Cell projection, dendrite Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q03141-1; Sequence=Displayed; Name=2; Synonyms=ELKL motif kinase 2 short form; IsoId=Q03141-2; Sequence=VSP_016140; Name=3; Synonyms=ELKL motif kinase 2 long form; IsoId=Q03141-3; Sequence=VSP_016141; Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20- related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Sequence=AAH26445.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC35922.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding microtubule cytoskeleton organization protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm plasma membrane protein phosphorylation membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation dendrite positive regulation of protein binding negative regulation of hippo signaling intracellular signal transduction peptidyl-serine autophosphorylation cell projection tau-protein kinase activity uc007pdk.1 uc007pdk.2 uc007pdk.3 uc007pdk.4 
ENSMUST00000084968.14 Rcor1 ENSMUST00000084968.14 REST corepressor 1 (from RefSeq NM_198023.3) D12Wsu95e ENSMUST00000084968.1 ENSMUST00000084968.10 ENSMUST00000084968.11 ENSMUST00000084968.12 ENSMUST00000084968.13 ENSMUST00000084968.2 ENSMUST00000084968.3 ENSMUST00000084968.4 ENSMUST00000084968.5 ENSMUST00000084968.6 ENSMUST00000084968.7 ENSMUST00000084968.8 ENSMUST00000084968.9 K3W4P9 Kiaa0071 NM_198023 Q3V092 Q8BK28 Q8CFE3 Q8CHI2 RCOR1_MOUSE uc007pck.1 uc007pck.2 uc007pck.3 uc007pck.4 Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with REST. Interacts with the SMARCE1/BAF57, suggesting that the BHC complex may recruit the ATP-dependent chromatin-remodeling SWI- SNF complex (By similarity). Interacts directly with GFI1 and GFI1B in a RCOR/GFI/KDM1A/HDAC complex. Interacts with INMS1. Interacts with SOX2 (PubMed:30442713). Q8CFE3; Q6ZQ88: Kdm1a; NbExp=2; IntAct=EBI-2337309, EBI-1216284; Q8CFE3; Q06219: Nr4a2; NbExp=5; IntAct=EBI-2337309, EBI-2337255; Nucleus Expressed in the external germinal layer (EGL) and internal granular layer (IGL) of the cerebellum and in Purkinje cells (at protein level). At embryonic day 8.5, it is highly expressed in the head mesenchyme, but neither in the somites nor in the presomitic mesoderm. By day 11.5 it is expressed fairly ubiquitously throughout the embryo. Down-regulated by the transcriptional repressor ZEB1 during NEUROD2-induced neurogenesis. The SANT domains may bridge the nucleosomal substrates and the demethylase KDM1A. Belongs to the CoREST family. Sequence=AAH42731.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus transcription factor complex chromatin organization transcription factor binding negative regulation of gene expression transcriptional repressor complex enzyme binding erythrocyte differentiation transcription regulatory region DNA binding positive regulation of megakaryocyte differentiation negative regulation of transcription, DNA-templated histone H4 deacetylation DNA repair complex uc007pck.1 uc007pck.2 uc007pck.3 uc007pck.4 
ENSMUST00000084984.8 Fbxw16 ENSMUST00000084984.8 F-box and WD-40 domain protein 16 (from RefSeq NM_177070.3) ENSMUST00000084984.1 ENSMUST00000084984.2 ENSMUST00000084984.3 ENSMUST00000084984.4 ENSMUST00000084984.5 ENSMUST00000084984.6 ENSMUST00000084984.7 Fbxw16 NM_177070 Q497Z0 Q497Z0_MOUSE uc009rsj.1 uc009rsj.2 uc009rsj.3 molecular_function cellular_component biological_process uc009rsj.1 uc009rsj.2 uc009rsj.3 
ENSMUST00000084985.11 Ppp2r5c ENSMUST00000084985.11 protein phosphatase 2, regulatory subunit B', gamma, transcript variant 1 (from RefSeq NM_012023.4) 2A5G_MOUSE ENSMUST00000084985.1 ENSMUST00000084985.10 ENSMUST00000084985.2 ENSMUST00000084985.3 ENSMUST00000084985.4 ENSMUST00000084985.5 ENSMUST00000084985.6 ENSMUST00000084985.7 ENSMUST00000084985.8 ENSMUST00000084985.9 NM_012023 O35708 Q60996 Q6TQF7 Q99KW8 Q99N67 Q99N68 uc007pbl.1 uc007pbl.2 uc007pbl.3 uc007pbl.4 uc007pbl.5 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A- PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1 (By similarity). Interacts with SGO1; the interaction is direct. May interact with TP53 (By similarity). Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation (By similarity). Interacts with CIP2A; this interaction stabilizes CIP2A (By similarity). Q60996-3; P30153: PPP2R1A; Xeno; NbExp=2; IntAct=EBI-1369292, EBI-302388; Nucleus Chromosome, centromere Event=Alternative splicing; Named isoforms=4; Name=2; Synonyms=Gamma-2; IsoId=Q60996-1; Sequence=Displayed; Name=1; Synonyms=Gamma-1; IsoId=Q60996-2; Sequence=VSP_014719, VSP_014720; Name=3; Synonyms=Gamma-3; IsoId=Q60996-3; Sequence=VSP_014718; Name=4; Synonyms=Gamma-4; IsoId=Q60996-4; Sequence=VSP_038641, VSP_038642; Highest levels in heart, liver and brain. Lower levels in skeletal muscle, spleen, kidney and lung. Isoform 4 is testis-specific. Belongs to the phosphatase 2A regulatory subunit B56 family. protein phosphatase type 2A complex chromosome, centromeric region protein binding nucleus nucleoplasm chromosome Golgi apparatus cytosol protein dephosphorylation signal transduction negative regulation of cell proliferation protein phosphatase regulator activity regulation of protein autophosphorylation proteasome-mediated ubiquitin-dependent protein catabolic process regulation of phosphoprotein phosphatase activity protein phosphatase activator activity uc007pbl.1 uc007pbl.2 uc007pbl.3 uc007pbl.4 uc007pbl.5 
ENSMUST00000085018.6 Ip6k2 ENSMUST00000085018.6 inositol hexaphosphate kinase 2, transcript variant 1 (from RefSeq NM_029634.2) E9QMT6 ENSMUST00000085018.1 ENSMUST00000085018.2 ENSMUST00000085018.3 ENSMUST00000085018.4 ENSMUST00000085018.5 IP6K2_MOUSE Ihpk2 NM_029634 Q80V72 uc009rqx.1 uc009rqx.2 uc009rqx.3 Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) (By similarity). May play a role in the regulation of Na(+)-dependent phosphate cotransport, possibly via its role in diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) biosynthesis (By similarity). Reaction=1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo- inositol 1,2,3,4,6-pentakisphosphate + ADP; Xref=Rhea:RHEA:12793, ChEBI:CHEBI:30616, ChEBI:CHEBI:58130, ChEBI:CHEBI:58628, ChEBI:CHEBI:456216; Phospholipid metabolism; phosphatidylinositol metabolism. Nucleus Highly expressed in brain and lung, and at slightly lower levels in liver, kidney and testis. Belongs to the inositol phosphokinase (IPK) family. nucleotide binding inositol hexakisphosphate kinase activity inositol hexakisphosphate 5-kinase activity fibrillar center ATP binding nucleus lipid metabolic process phosphate ion transport kinase activity phosphorylation transferase activity cell junction negative regulation of cell growth inositol phosphate biosynthetic process positive regulation of apoptotic process inositol phosphate metabolic process phosphatidylinositol metabolic process phosphatidylinositol phosphorylation flavonoid binding cellular response to flavonoid uc009rqx.1 uc009rqx.2 uc009rqx.3 
ENSMUST00000085027.4 Nhlrc4 ENSMUST00000085027.4 NHL repeat containing 4 (from RefSeq NM_001039038.2) ENSMUST00000085027.1 ENSMUST00000085027.2 ENSMUST00000085027.3 NHLC4_MOUSE NM_001039038 Q3UP44 uc008bcu.1 uc008bcu.2 uc008bcu.3 cellular_component ubiquitin protein ligase activity protein K48-linked ubiquitination uc008bcu.1 uc008bcu.2 uc008bcu.3 
ENSMUST00000085040.5 Gpr171 ENSMUST00000085040.5 G protein-coupled receptor 171 (from RefSeq NM_173398.3) ENSMUST00000085040.1 ENSMUST00000085040.2 ENSMUST00000085040.3 ENSMUST00000085040.4 GP171_MOUSE NM_173398 Q8BG55 Q8BTN1 Q8BY85 Q8CIF3 uc008pij.1 uc008pij.2 uc008pij.3 G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N) (PubMed:24043826, PubMed:28425495). Acts through a G(i)-alpha- mediated pathway in response to Big LEN (PubMed:24043826). Big LEN- GPR171 system plays an important role in regulating feeding and metabolism (PubMed:24043826). Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala (PubMed:28425495). Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (PubMed:31308196). Acts as a negative regulator T cell function (PubMed:34615877). Cell membrane ulti-pass membrane protein Note=Colocalized with GPR83 in the paraventricular nucleus. Highly expressed in hypothalamus, including the arcuate nucleus, paraventricular nucleus and dorsomedial hypothalamus (PubMed:24043826). Expressed in periaqueductal gray (at protein level), found primarily in GABAergic neurons and to a lesser extent in glutamatergic neurons (PubMed:31308196). Expressed in T cells and natural killer cells (PubMed:34615877). Induced upon antigen stimulation. Deficient mice exhibit stronger antitumor immunity. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane G-protein coupled purinergic nucleotide receptor signaling pathway G-protein coupled purinergic nucleotide receptor activity negative regulation of myeloid cell differentiation uc008pij.1 uc008pij.2 uc008pij.3 
ENSMUST00000085043.7 Tcl1b1 ENSMUST00000085043.7 T cell leukemia/lymphoma 1B, 1 (from RefSeq NM_013773.2) ENSMUST00000085043.1 ENSMUST00000085043.2 ENSMUST00000085043.3 ENSMUST00000085043.4 ENSMUST00000085043.5 ENSMUST00000085043.6 NM_013773 Q3UWQ4 Q3UWQ4_MOUSE Tcl1b1 uc007oxx.1 uc007oxx.2 uc007oxx.3 Belongs to the TCL1 family. protein serine/threonine kinase activator activity positive regulation of protein serine/threonine kinase activity uc007oxx.1 uc007oxx.2 uc007oxx.3 
ENSMUST00000085050.4 Serpina3c ENSMUST00000085050.4 serine (or cysteine) peptidase inhibitor, clade A, member 3C (from RefSeq NM_008458.2) ENSMUST00000085050.1 ENSMUST00000085050.2 ENSMUST00000085050.3 Klkbp NM_008458 P29621 SPA3C_MOUSE uc007owv.1 uc007owv.2 uc007owv.3 Secreted The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity. The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 14 individual murine paralogs. Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular region extracellular space negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to cytokine response to peptide hormone uc007owv.1 uc007owv.2 uc007owv.3 
ENSMUST00000085052.3 Serpina3b ENSMUST00000085052.3 serine (or cysteine) peptidase inhibitor, clade A, member 3B (from RefSeq NM_173024.3) ENSMUST00000085052.1 ENSMUST00000085052.2 NM_173024 Q8BYY9 SPA3B_MOUSE uc007owu.1 uc007owu.2 Secreted The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity. The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 14 individual murine paralogs. Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular region extracellular space negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc007owu.1 uc007owu.2 
ENSMUST00000085056.8 Serpina1a ENSMUST00000085056.8 serine (or cysteine) peptidase inhibitor, clade A, member 1A, transcript variant 1 (from RefSeq NM_009243.4) A1AT1_MOUSE Dom1 ENSMUST00000085056.1 ENSMUST00000085056.2 ENSMUST00000085056.3 ENSMUST00000085056.4 ENSMUST00000085056.5 ENSMUST00000085056.6 ENSMUST00000085056.7 NM_009243 P07758 Q3UJ47 Q80YB8 Q8JZV6 Q91XB8 Spi1-1 uc007owi.1 uc007owi.2 uc007owi.3 uc007owi.4 Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Secreted The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin- protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity. Murine alpha-1-antitrypsin is represented by a cluster of up to 6 individual Serpina1-related genes. The precise complement of Serpina1-related genes present varies according to the strain of the animal. Belongs to the serpin family. protease binding endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity protein binding extracellular region extracellular space endoplasmic reticulum Golgi apparatus protein N-linked glycosylation acute-phase response negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to cytokine identical protein binding intracellular membrane-bounded organelle response to peptide hormone uc007owi.1 uc007owi.2 uc007owi.3 uc007owi.4 
ENSMUST00000085060.3 Amigo3 ENSMUST00000085060.3 adhesion molecule with Ig like domain 3 (from RefSeq NM_177275.4) AMGO3_MOUSE Ali3 Amigo3 ENSMUST00000085060.1 ENSMUST00000085060.2 Kiaa1851 NM_177275 Q6ZPH1 Q8C2S7 Q8CEB3 uc009rom.1 uc009rom.2 May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity). Binds AMIGO1 or AMIGO2. Membrane ; Single-pass type I membrane protein Ubiquitous. Belongs to the immunoglobulin superfamily. AMIGO family. Sequence=BAC26035.1; Type=Frameshift; Evidence=; Sequence=BAC98266.1; Type=Erroneous initiation; Evidence=; molecular_function cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules nervous system development brain development negative regulation of neuron projection development membrane integral component of membrane macromolecular complex binding positive regulation of synapse assembly uc009rom.1 uc009rom.2 
ENSMUST00000085073.2 Actl11 ENSMUST00000085073.2 actin-like 11 (from RefSeq NM_026338.3) 4921517D21Rik Actl11 ENSMUST00000085073.1 NM_026338 Q9D5V1 Q9D5V1_MOUSE uc009rnj.1 uc009rnj.2 Belongs to the actin family. molecular_function biological_process actin cytoskeleton uc009rnj.1 uc009rnj.2 
ENSMUST00000085077.5 Arnt2 ENSMUST00000085077.5 aryl hydrocarbon receptor nuclear translocator 2, transcript variant 1 (from RefSeq NM_007488.4) ARNT2_MOUSE ENSMUST00000085077.1 ENSMUST00000085077.2 ENSMUST00000085077.3 ENSMUST00000085077.4 Kiaa0307 NM_007488 Q61324 Q7TQG2 Q8CHG9 uc009ieh.1 uc009ieh.2 uc009ieh.3 uc009ieh.4 Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE). Efficient DNA binding requires dimerization with another bHLH protein (By similarity). Heterodimer with NPAS4 or SIM1 (PubMed:27782878). Heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein (By similarity). Interacts with TACC3 (PubMed:11025203). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61324-1; Sequence=Displayed; Name=2; IsoId=Q61324-2; Sequence=VSP_022689; Restricted to adult brain and kidney. Sequence=BAC41409.1; Type=Erroneous initiation; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding response to hypoxia in utero embryonic development DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm regulation of transcription, DNA-templated signal transduction central nervous system development brain development positive regulation of cell proliferation response to xenobiotic stimulus response to toxic substance aryl hydrocarbon receptor binding response to estradiol negative regulation of apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity uc009ieh.1 uc009ieh.2 uc009ieh.3 uc009ieh.4 
ENSMUST00000085102.6 Cish ENSMUST00000085102.6 cytokine inducible SH2-containing protein, transcript variant 1 (from RefSeq NM_009895.4) CISH_MOUSE Cis ENSMUST00000085102.1 ENSMUST00000085102.2 ENSMUST00000085102.3 ENSMUST00000085102.4 ENSMUST00000085102.5 NM_009895 Q3TC70 Q62225 uc009rlc.1 uc009rlc.2 uc009rlc.3 uc009rlc.4 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Protein modification; protein ubiquitination. Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR). Q62225; P19235: EPOR; Xeno; NbExp=4; IntAct=EBI-617489, EBI-617321; Expressed in kidney, lung and liver. Detected to a lower extent in stomach and heart. In the developing brain, expressed at low levels from 10 dpc stages to young adulthood (P25) with peak levels from 14 dpc to P8. By a subset of cytokines including interleukins 2, 3 and 6, granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (EPO). protein binding plasma membrane phosphatidylinositol 3-kinase complex protein kinase C-activating G-protein coupled receptor signaling pathway negative regulation of signal transduction protein ubiquitination intracellular signal transduction regulation of growth regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity uc009rlc.1 uc009rlc.2 uc009rlc.3 uc009rlc.4 
ENSMUST00000085108.8 Foxn3 ENSMUST00000085108.8 forkhead box N3 (from RefSeq NM_183186.2) Ches1 ENSMUST00000085108.1 ENSMUST00000085108.2 ENSMUST00000085108.3 ENSMUST00000085108.4 ENSMUST00000085108.5 ENSMUST00000085108.6 ENSMUST00000085108.7 FOXN3_MOUSE NM_183186 Q499D0 Q8C5N8 Q9CU83 uc007ort.1 uc007ort.2 Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints) (By similarity). Interacts through its C-terminus with the C-terminus of SNW1/SKIP. Nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated cell cycle mitotic G2 DNA damage checkpoint protein C-terminus binding sequence-specific DNA binding negative regulation of transcription, DNA-templated craniofacial suture morphogenesis uc007ort.1 uc007ort.2 
ENSMUST00000085109.10 Ttc8 ENSMUST00000085109.10 tetratricopeptide repeat domain 8, transcript variant 2 (from RefSeq NM_029553.4) Bbs8 ENSMUST00000085109.1 ENSMUST00000085109.2 ENSMUST00000085109.3 ENSMUST00000085109.4 ENSMUST00000085109.5 ENSMUST00000085109.6 ENSMUST00000085109.7 ENSMUST00000085109.8 ENSMUST00000085109.9 NM_029553 Q8VD72 Q9DCP7 TTC8_MOUSE uc007orp.1 uc007orp.2 uc007orp.3 uc007orp.4 The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (By similarity). Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts with PCM1. Interacts with CCDC28B. Interacts with PKD1. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cell projection, cilium membrane Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cell projection, cilium Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VD72-1; Sequence=Displayed; Name=2; IsoId=Q8VD72-2; Sequence=VSP_007825; Isoform 1 is retina-specific whereas isoform 2 is ubiquitously expressed. Expressed at 12 dpc in ciliated structures, including maturing (stages X and XI) spermatids, the connecting cilium of the retina and bronchial epithelial cells. At 14 and 16 dpc, detected in the telencephalon, with prominent expression at the developing ependymal cell layer and the olfactory epithelium. RNA polymerase II repressing transcription factor binding establishment of planar polarity protein binding cytoplasm centrosome centriole microtubule organizing center cytoskeleton plasma membrane cilium axon guidance sensory perception of smell protein transport membrane olfactory bulb development cell projection organization photoreceptor connecting cilium regulation of protein localization negative regulation of GTPase activity BBSome multicellular organism growth ciliary basal body cell projection fat cell differentiation establishment of anatomical structure orientation regulation of stress fiber assembly inner ear receptor stereocilium organization ciliary membrane camera-type eye photoreceptor cell differentiation cilium assembly renal tubule development protein localization to plasma membrane non-motile cilium multi-ciliated epithelial cell differentiation non-motile cilium assembly uc007orp.1 uc007orp.2 uc007orp.3 uc007orp.4 
ENSMUST00000085111.5 Iqcf4 ENSMUST00000085111.5 IQ motif containing F4 (from RefSeq NM_026090.2) ENSMUST00000085111.1 ENSMUST00000085111.2 ENSMUST00000085111.3 ENSMUST00000085111.4 Iqcf4 NM_026090 Q6P8Y2 Q6P8Y2_MOUSE uc009rkh.1 uc009rkh.2 uc009rkh.3 calmodulin binding uc009rkh.1 uc009rkh.2 uc009rkh.3 
ENSMUST00000085113.5 Iqcf5 ENSMUST00000085113.5 IQ motif containing F5 (from RefSeq NM_029300.1) ENSMUST00000085113.1 ENSMUST00000085113.2 ENSMUST00000085113.3 ENSMUST00000085113.4 IQCF5_MOUSE NM_029300 Q9DAL7 uc009rkf.1 uc009rkf.2 uc009rkf.3 calmodulin binding cellular_component biological_process uc009rkf.1 uc009rkf.2 uc009rkf.3 
ENSMUST00000085144.11 Pramel25 ENSMUST00000085144.11 PRAME like 25, transcript variant 1 (from RefSeq NM_001007077.2) A2A8N2 A2A8N2_MOUSE ENSMUST00000085144.1 ENSMUST00000085144.10 ENSMUST00000085144.2 ENSMUST00000085144.3 ENSMUST00000085144.4 ENSMUST00000085144.5 ENSMUST00000085144.6 ENSMUST00000085144.7 ENSMUST00000085144.8 ENSMUST00000085144.9 NM_001007077 Pramel25 uc008vql.1 uc008vql.2 uc008vql.3 uc008vql.4 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vql.1 uc008vql.2 uc008vql.3 uc008vql.4 
ENSMUST00000085177.5 Msl2 ENSMUST00000085177.5 MSL complex subunit 2, transcript variant 1 (from RefSeq NM_001100451.2) ENSMUST00000085177.1 ENSMUST00000085177.2 ENSMUST00000085177.3 ENSMUST00000085177.4 Kiaa1585 MSL2_MOUSE Msl2l1 NM_001100451 Q497U7 Q69ZF8 Q8CBI7 Rnf184 uc033jml.1 uc033jml.2 uc033jml.3 Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure (By similarity). Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity). Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Forms a MSL heterotetrameric core with MSL1. Belongs to the MSL2 family. Sequence=BAD32486.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein ubiquitination transferase activity histone H4-K16 acetylation metal ion binding ubiquitin protein ligase activity MSL complex uc033jml.1 uc033jml.2 uc033jml.3 
ENSMUST00000085192.7 Aldh6a1 ENSMUST00000085192.7 aldehyde dehydrogenase family 6, subfamily A1, transcript variant 1 (from RefSeq NM_134042.3) Aldh6a1 ENSMUST00000085192.1 ENSMUST00000085192.2 ENSMUST00000085192.3 ENSMUST00000085192.4 ENSMUST00000085192.5 ENSMUST00000085192.6 MMSA_MOUSE NM_134042 Q3TDA2 Q8CIB4 Q9EQ20 uc007ofk.1 uc007ofk.2 uc007ofk.3 uc007ofk.4 uc007ofk.5 uc007ofk.6 This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded enzyme is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This enzyme catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Mutations in the human gene result in Methylmalonate Semialdehyde Dehydrogenase Deficiency, characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine. Reaction=3-oxopropanoate + CoA + H2O + NAD(+) = acetyl-CoA + H(+) + hydrogencarbonate + NADH; Xref=Rhea:RHEA:76615, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:33190, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.27; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76616; Evidence=; Reaction=2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA; Xref=Rhea:RHEA:20804, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392, ChEBI:CHEBI:57540, ChEBI:CHEBI:57700, ChEBI:CHEBI:57945; EC=1.2.1.27; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20805; Evidence=; Reaction=(R)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA; Xref=Rhea:RHEA:76623, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:141212; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76624; Evidence=; Reaction=(S)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA; Xref=Rhea:RHEA:76627, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62413; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76628; Evidence=; Homotetramer. Mitochondrion Acetylation of Lys-55; Lys-117 and Lys-331 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the aldehyde dehydrogenase family. methylmalonate-semialdehyde dehydrogenase (acylating) activity nucleoplasm mitochondrion thymine catabolic process valine metabolic process valine catabolic process oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor thiolester hydrolase activity malonate-semialdehyde dehydrogenase (acetylating) activity beta-alanine catabolic process thymine metabolic process brown fat cell differentiation oxidation-reduction process uc007ofk.1 uc007ofk.2 uc007ofk.3 uc007ofk.4 uc007ofk.5 uc007ofk.6 
ENSMUST00000085206.11 Slc25a36 ENSMUST00000085206.11 solute carrier family 25, member 36 (from RefSeq NM_138756.4) ENSMUST00000085206.1 ENSMUST00000085206.10 ENSMUST00000085206.2 ENSMUST00000085206.3 ENSMUST00000085206.4 ENSMUST00000085206.5 ENSMUST00000085206.6 ENSMUST00000085206.7 ENSMUST00000085206.8 ENSMUST00000085206.9 NM_138756 Q922G0 S2536_MOUSE uc009rdb.1 uc009rdb.2 uc009rdb.3 Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports cytosine, guanosine, inosine and uridine (deoxy)nucleoside mono-, di-, and triphosphates by antiport mechanism. Catalyzes uniport at much lower rate (By similarity). May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside mono- and diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (By similarity). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (By similarity). Reaction=CTP(out) + UTP(in) = CTP(in) + UTP(out); Xref=Rhea:RHEA:73531, ChEBI:CHEBI:37563, ChEBI:CHEBI:46398; Evidence=; Reaction=CTP(out) + UDP(in) = CTP(in) + UDP(out); Xref=Rhea:RHEA:73583, ChEBI:CHEBI:37563, ChEBI:CHEBI:58223; Evidence=; Reaction=CTP(out) + UMP(in) = CTP(in) + UMP(out); Xref=Rhea:RHEA:73587, ChEBI:CHEBI:37563, ChEBI:CHEBI:57865; Evidence=; Reaction=CTP(out) + dUTP(in) = CTP(in) + dUTP(out); Xref=Rhea:RHEA:73591, ChEBI:CHEBI:37563, ChEBI:CHEBI:61555; Evidence=; Reaction=CTP(out) + dUMP(in) = CTP(in) + dUMP(out); Xref=Rhea:RHEA:73595, ChEBI:CHEBI:37563, ChEBI:CHEBI:246422; Evidence=; Reaction=CDP(in) + CTP(out) = CDP(out) + CTP(in); Xref=Rhea:RHEA:73599, ChEBI:CHEBI:37563, ChEBI:CHEBI:58069; Evidence=; Reaction=CMP(in) + CTP(out) = CMP(out) + CTP(in); Xref=Rhea:RHEA:73603, ChEBI:CHEBI:37563, ChEBI:CHEBI:60377; Evidence=; Reaction=CTP(out) + dCTP(in) = CTP(in) + dCTP(out); Xref=Rhea:RHEA:73607, ChEBI:CHEBI:37563, ChEBI:CHEBI:61481; Evidence=; Reaction=CTP(out) + dCDP(in) = CTP(in) + dCDP(out); Xref=Rhea:RHEA:73611, ChEBI:CHEBI:37563, ChEBI:CHEBI:58593; Evidence=; Reaction=CTP(out) + dCMP(in) = CTP(in) + dCMP(out); Xref=Rhea:RHEA:73615, ChEBI:CHEBI:37563, ChEBI:CHEBI:57566; Evidence=; Reaction=CTP(out) + GTP(in) = CTP(in) + GTP(out); Xref=Rhea:RHEA:73619, ChEBI:CHEBI:37563, ChEBI:CHEBI:37565; Evidence=; Reaction=CTP(out) + GDP(in) = CTP(in) + GDP(out); Xref=Rhea:RHEA:73623, ChEBI:CHEBI:37563, ChEBI:CHEBI:58189; Evidence=; Reaction=CTP(out) + GMP(in) = CTP(in) + GMP(out); Xref=Rhea:RHEA:73627, ChEBI:CHEBI:37563, ChEBI:CHEBI:58115; Evidence=; Reaction=CTP(out) + dGTP(in) = CTP(in) + dGTP(out); Xref=Rhea:RHEA:73631, ChEBI:CHEBI:37563, ChEBI:CHEBI:61429; Evidence=; Reaction=CTP(out) + dGMP(in) = CTP(in) + dGMP(out); Xref=Rhea:RHEA:73635, ChEBI:CHEBI:37563, ChEBI:CHEBI:57673; Evidence=; Reaction=CTP(out) + ITP(in) = CTP(in) + ITP(out); Xref=Rhea:RHEA:73639, ChEBI:CHEBI:37563, ChEBI:CHEBI:61402; Evidence=; Reaction=CTP(out) + IDP(in) = CTP(in) + IDP(out); Xref=Rhea:RHEA:73643, ChEBI:CHEBI:37563, ChEBI:CHEBI:58280; Evidence=; Reaction=CTP(out) + IMP(in) = CTP(in) + IMP(out); Xref=Rhea:RHEA:73647, ChEBI:CHEBI:37563, ChEBI:CHEBI:58053; Evidence=; Reaction=CTP(out) = CTP(in); Xref=Rhea:RHEA:73651, ChEBI:CHEBI:37563; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. mitochondrial genome maintenance mitochondrion mitochondrial inner membrane pyrimidine nucleotide transport mitochondrion organization pyrimidine nucleotide transmembrane transporter activity membrane integral component of membrane transmembrane transporter activity regulation of mitochondrial membrane potential transmembrane transport mitochondrial pyrimidine nucleotide import uc009rdb.1 uc009rdb.2 uc009rdb.3 
ENSMUST00000085217.12 Gk5 ENSMUST00000085217.12 glycerol kinase 5, transcript variant 1 (from RefSeq NM_001368879.1) ENSMUST00000085217.1 ENSMUST00000085217.10 ENSMUST00000085217.11 ENSMUST00000085217.2 ENSMUST00000085217.3 ENSMUST00000085217.4 ENSMUST00000085217.5 ENSMUST00000085217.6 ENSMUST00000085217.7 ENSMUST00000085217.8 ENSMUST00000085217.9 GLPK5_MOUSE NM_001368879 Q14B67 Q3TK02 Q3TSE0 Q80VA9 Q8BX05 uc009rbz.1 uc009rbz.2 uc009rbz.3 Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216; EC=2.7.1.30; Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BX05-1; Sequence=Displayed; Name=2; IsoId=Q8BX05-2; Sequence=VSP_032125; Name=3; IsoId=Q8BX05-3; Sequence=VSP_032124, VSP_032125; Belongs to the FGGY kinase family. Sequence=AAH50033.1; Type=Erroneous initiation; Evidence=; nucleotide binding glycerol kinase activity ATP binding mitochondrion carbohydrate metabolic process glycerol metabolic process triglyceride metabolic process kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor glycerol catabolic process glycerol-3-phosphate biosynthetic process uc009rbz.1 uc009rbz.2 uc009rbz.3 
ENSMUST00000085238.13 Slc8a3 ENSMUST00000085238.13 solute carrier family 8 (sodium/calcium exchanger), member 3, transcript variant 3 (from RefSeq NM_001422654.1) ENSMUST00000085238.1 ENSMUST00000085238.10 ENSMUST00000085238.11 ENSMUST00000085238.12 ENSMUST00000085238.2 ENSMUST00000085238.3 ENSMUST00000085238.4 ENSMUST00000085238.5 ENSMUST00000085238.6 ENSMUST00000085238.7 ENSMUST00000085238.8 ENSMUST00000085238.9 NAC3_MOUSE NM_001422654 Ncx3 Q7TS90 Q8VHJ8 S4R2P9 Slc8a3 uc007obw.1 uc007obw.2 uc007obw.3 uc007obw.4 Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain (PubMed:14722618, PubMed:21593315). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:14722618, PubMed:21593315). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:14722618). In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (PubMed:21593315). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (PubMed:24616101). Isoform 1 displays higher calcium exchanger activity than isoform 2, probably because isoform 1 has a lower threshold for activation by cytoplasmic Ca(2+) (PubMed:24616101). Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in); Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108; Evidence=; Calcium transport is stimulated by cytoplasmic Ca(2+) and is inhibited by Na(+). Isoform 1 is more sensitive to stimulation by Ca(2+) than isoform 2. Isoform 2 is more sensitive to inactivation by Na(+). Interacts with AKAP1. Cell membrane ulti-pass membrane protein Perikaryon Cell projection, dendrite Cell projection, dendritic spine Cell membrane, sarcolemma Cytoplasm, sarcoplasm Cell junction Mitochondrion outer membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Detected at neuromuscular junctions. [Isoform 1]: Cell membrane ; Multi-pass membrane protein [Isoform 2]: Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=NCX3-AC ; IsoId=S4R2P9-1; Sequence=Displayed; Name=2; Synonyms=NCX3-B ; IsoId=S4R2P9-2; Sequence=VSP_057981; Detected in gray and white matter in the spinal cord (PubMed:21959935). Detected in hippocampus neurons (PubMed:21593315). Detected in brain cortex neurons (PubMed:24101730). Detected in skeletal muscle (at protein level) (PubMed:14722618). Isoform 1 and isoform 2 are highly expressed in brain; levels are higher for isoform 2 (PubMed:24616101). Isoform 1 and isoform 2 are detected in soleus muscle; levels are higher for isoform 1 (PubMed:24616101). Detected in gastrocnemius muscle (PubMed:14722618). Down-regulated by hypoxia combined with glucose deprivation (at protein level). The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium- regulated ion exchange. Mice appear grossly normal, are viable and fertile, but display muscle fiber necrosis; this affects less than 10% of all fibers. Muscle fibers from flexor digitorum brevis show lack of calcium exchange activity, and very slow return of cytoplasmic Ca(2+) to baseline levels after stimulation with caffeine, a stimulus that triggers release of Ca(2+) stores from the sarcoplasmic reticulum. Mutant mice display decreased endurance and perform poorly on the rota- rod test or when hanging from a taut wire, indicating poor coordination and increased fatigue (PubMed:14722618). Mutant mice display increased cytoplasmic Ca(2+) levels and increased delays in the decrease of cytoplasmic Ca(2+) back to baseline levels after stimulation of hippocampus neurons (PubMed:21593315). They show impaired synaptic transmisison, impaired long-term potentiation, impaired learning and memory (PubMed:21593315). Besides, mutant mice display a decreased size of the spinal cord, decreased myelination, decreased numbers of oligodendrocytes and increased numbers of oligodendrocyte precursor cells (PubMed:21959935). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. hematopoietic progenitor cell differentiation calcium:sodium antiporter activity calmodulin binding cytoplasm mitochondrion mitochondrial outer membrane endoplasmic reticulum endoplasmic reticulum membrane microtubule plasma membrane integral component of plasma membrane ion transport sodium ion transport calcium ion transport mitochondrial calcium ion transport cellular calcium ion homeostasis cell communication learning memory regulation of skeletal muscle contraction antiporter activity calcium:cation antiporter activity membrane integral component of membrane sarcoplasm telencephalon development metal ion transport cell junction dendrite intrinsic component of plasma membrane neuromuscular junction sodium ion transmembrane transport sarcolemma myelination cell projection neuronal cell body dendritic spine perikaryon metal ion binding perinuclear region of cytoplasm oligodendrocyte differentiation mitochondrial calcium ion homeostasis transmembrane transport long-term synaptic potentiation calcium ion transport into cytosol calcium ion transmembrane transport cellular response to cAMP cellular response to hypoxia calcium ion import across plasma membrane integral component of postsynaptic membrane regulation of postsynaptic cytosolic calcium ion concentration ion antiporter activity involved in regulation of postsynaptic membrane potential calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration calcium ion export from cell uc007obw.1 uc007obw.2 uc007obw.3 uc007obw.4 
ENSMUST00000085245.7 Slc39a9 ENSMUST00000085245.7 solute carrier family 39 (zinc transporter), member 9 (from RefSeq NM_026244.2) B2RY14 ENSMUST00000085245.1 ENSMUST00000085245.2 ENSMUST00000085245.3 ENSMUST00000085245.4 ENSMUST00000085245.5 ENSMUST00000085245.6 NM_026244 Q8BFU1 S39A9_MOUSE Slc39a9 Zip9 uc007obc.1 uc007obc.2 uc007obc.3 uc007obc.4 Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation (By similarity). Also functions as a membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (PubMed:26208885). This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity). Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription. Moreover, has dual functions as a membrane-bound androgen receptor and as an androgen- dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (By similarity). Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence=; Golgi apparatus, trans-Golgi network membrane Cell membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region Mitochondrion Nucleus Belongs to the ZIP transporter (TC 2.A.5) family. molecular_function cellular_component ion transport zinc II ion transport biological_process membrane integral component of membrane metal ion transport metal ion transmembrane transporter activity transmembrane transport uc007obc.1 uc007obc.2 uc007obc.3 uc007obc.4 
ENSMUST00000085256.8 Mthfs ENSMUST00000085256.8 5, 10-methenyltetrahydrofolate synthetase, transcript variant 1 (from RefSeq NM_026829.2) B2KF82 ENSMUST00000085256.1 ENSMUST00000085256.2 ENSMUST00000085256.3 ENSMUST00000085256.4 ENSMUST00000085256.5 ENSMUST00000085256.6 ENSMUST00000085256.7 MTHFS_MOUSE NM_026829 Q9D110 uc009qzk.1 uc009qzk.2 uc009qzk.3 Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5- formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10- methenyltetrahydrofolate (By similarity). Reaction=(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10- methenyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:10488, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57455, ChEBI:CHEBI:57457, ChEBI:CHEBI:456216; EC=6.3.3.2; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Monomer. Cytoplasm Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. nucleotide binding ATP binding folic acid binding cytoplasm mitochondrion mitochondrial matrix cytosol folic acid-containing compound biosynthetic process ligase activity 5-formyltetrahydrofolate cyclo-ligase activity tetrahydrofolate interconversion tetrahydrofolate metabolic process metal ion binding uc009qzk.1 uc009qzk.2 uc009qzk.3 
ENSMUST00000085272.7 Htatip2 ENSMUST00000085272.7 HIV-1 Tat interactive protein 2, transcript variant 5 (from RefSeq NM_001146053.1) Cc3 ENSMUST00000085272.1 ENSMUST00000085272.2 ENSMUST00000085272.3 ENSMUST00000085272.4 ENSMUST00000085272.5 ENSMUST00000085272.6 HTAI2_MOUSE Htatip2 NM_001146053 Q810Y5 Q99KN6 Q9D5F8 Q9D804 Q9Z2G9 Tip30 uc009hbq.1 uc009hbq.2 uc009hbq.3 uc009hbq.4 Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA (By similarity). Cytoplasm Nucleus envelope Event=Alternative splicing; Named isoforms=2; Name=1 ; Synonyms=TIP30 , CC3 ; IsoId=Q9Z2G9-1; Sequence=Displayed; Name=2 ; IsoId=Q9Z2G9-2; Sequence=VSP_051866, VSP_051867; Mice are haploinsufficient for tumor suppression. 50% develop tumors within their second year. 30% of the tumors are hepatocellular carcinomas. angiogenesis protein serine/threonine kinase activity nucleus nuclear envelope cytoplasm cytosol apoptotic process multicellular organism development oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor cell differentiation positive regulation of programmed cell death regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation nuclear import NAD binding oxidation-reduction process uc009hbq.1 uc009hbq.2 uc009hbq.3 uc009hbq.4 
ENSMUST00000085311.13 Fbxo9 ENSMUST00000085311.13 f-box protein 9, transcript variant 1 (from RefSeq NM_023605.2) ENSMUST00000085311.1 ENSMUST00000085311.10 ENSMUST00000085311.11 ENSMUST00000085311.12 ENSMUST00000085311.2 ENSMUST00000085311.3 ENSMUST00000085311.4 ENSMUST00000085311.5 ENSMUST00000085311.6 ENSMUST00000085311.7 ENSMUST00000085311.8 ENSMUST00000085311.9 FBX9_MOUSE MNCb-2471 NM_023605 Q8BK06 Q8VDY6 Q9D349 Q9JJC5 uc033jlq.1 uc033jlq.2 uc033jlq.3 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1 (By similarity). Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway (By similarity). Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation (PubMed:23643813, PubMed:27197753). Protein modification; protein ubiquitination. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2. Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BK06-1; Sequence=Displayed; Name=2; IsoId=Q8BK06-2; Sequence=VSP_012929; Name=3; IsoId=Q8BK06-3; Sequence=VSP_012929, VSP_012930, VSP_012931; Sequence=BAA95068.1; Type=Frameshift; Evidence=; cytoplasm protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process regulation of TOR signaling innate immune response fat cell differentiation uc033jlq.1 uc033jlq.2 uc033jlq.3 
ENSMUST00000085319.4 Adam4 ENSMUST00000085319.4 a disintegrin and metallopeptidase domain 4 (from RefSeq NM_009620.2) Adam4 ENSMUST00000085319.1 ENSMUST00000085319.2 ENSMUST00000085319.3 NM_009620 Q8CGQ2 Q8CGQ2_MOUSE uc007ocd.1 uc007ocd.2 uc007ocd.3 uc007ocd.4 Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. metalloendopeptidase activity proteolysis integrin-mediated signaling pathway metallopeptidase activity external side of plasma membrane membrane integral component of membrane sperm head plasma membrane uc007ocd.1 uc007ocd.2 uc007ocd.3 uc007ocd.4 
ENSMUST00000085350.11 Ccpg1 ENSMUST00000085350.11 cell cycle progression 1, transcript variant 6 (from RefSeq NM_001359295.1) CCPG1_MOUSE ENSMUST00000085350.1 ENSMUST00000085350.10 ENSMUST00000085350.2 ENSMUST00000085350.3 ENSMUST00000085350.4 ENSMUST00000085350.5 ENSMUST00000085350.6 ENSMUST00000085350.7 ENSMUST00000085350.8 ENSMUST00000085350.9 NM_001359295 Q05BJ9 Q640L3 Q8C692 Q922W9 uc009qqp.1 uc009qqp.2 uc009qqp.3 uc009qqp.4 uc009qqp.5 uc009qqp.6 Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. May be involved in cell cycle regulation. Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1. Interacts with GTP-bound CDC42 and SRC. Cytoplasmic granule membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q640L3-1; Sequence=Displayed; Name=2; IsoId=Q640L3-2; Sequence=VSP_029318; Name=3; IsoId=Q640L3-3; Sequence=VSP_029317; Belongs to the CCPG1 family. Sequence=AAH06717.1; Type=Erroneous initiation; Evidence=; cell cycle positive regulation of cell proliferation membrane integral component of membrane positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter regulation of Rho guanyl-nucleotide exchange factor activity uc009qqp.1 uc009qqp.2 uc009qqp.3 uc009qqp.4 uc009qqp.5 uc009qqp.6 
ENSMUST00000085351.7 Hrc ENSMUST00000085351.7 histidine rich calcium binding protein (from RefSeq NM_010473.2) ENSMUST00000085351.1 ENSMUST00000085351.2 ENSMUST00000085351.3 ENSMUST00000085351.4 ENSMUST00000085351.5 ENSMUST00000085351.6 G5E8J6 G5E8J6_MOUSE Hrc NM_010473 uc009gur.1 uc009gur.2 uc009gur.3 uc009gur.4 calcium ion binding regulation of heart contraction sarcoplasmic reticulum membrane negative regulation of cytosolic calcium ion concentration calcium ion homeostasis negative regulation of calcium ion import into sarcoplasmic reticulum uc009gur.1 uc009gur.2 uc009gur.3 uc009gur.4 
ENSMUST00000085374.7 Slc17a7 ENSMUST00000085374.7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 (from RefSeq NM_182993.2) Bnpi E9QMT8 ENSMUST00000085374.1 ENSMUST00000085374.2 ENSMUST00000085374.3 ENSMUST00000085374.4 ENSMUST00000085374.5 ENSMUST00000085374.6 NM_182993 Q3TXX4 Slc17a7 VGLU1_MOUSE Vglut1 uc009gtx.1 uc009gtx.2 uc009gtx.3 uc009gtx.4 Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:29642010, PubMed:25433636, PubMed:33440152, PubMed:29273736). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:25433636, PubMed:29642010, PubMed:15103023, PubMed:15118123). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:29642010). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (PubMed:25433636, PubMed:29273736, PubMed:29642010). Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular K(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:33440152, PubMed:29642010). The symporter activity is driven by an inside negative membrane potential and is electrogenic (PubMed:29642010). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (PubMed:17611277). Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence= Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in); Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; Evidence=; Reaction=L-glutamate(out) = L-glutamate(in); Xref=Rhea:RHEA:66336, ChEBI:CHEBI:29985; Evidence= Reaction=phosphate(in) = phosphate(out); Xref=Rhea:RHEA:32823, ChEBI:CHEBI:43474; Evidence=; Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out); Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103; Evidence=; Chloride channel activity is allosterically activated by lumenal H(+) and Cl(-) leading to synaptic vesicles acidification. The L-glutamate transport activity is allosterically activated by lumenal H(+) and Cl(-). The allosteric activation by H(+) efficiently prevents non-vesicular efflux across the plasma membrane, thereby restricting L-glutamate transport activity to acidic membranes such as synaptic vesicles. Kinetic parameters: KM=1.09 mM for L-glutamate ; KM=1.44 mM for L-glutamate (with 300mM of inorganic phosphate) ; KM=4.3 mM for inorganic phosphate ; Vmax=1.57 nmol/min/mg enzyme toward L-glutamate ; Vmax=0.58 nmol/min/mg enzyme toward L-glutamate (with 300mM of inorganic phosphate) ; Vmax=2.09 nmol/min/mg enzyme toward inorganic phosphate ; Interacts with SHANK3. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Cell membrane ; Multi-pass membrane protein Synapse, synaptosome Expressed in hippocampus (at protein level). Expressed in the molecular layer of the cerebellum and in retina. Expression in brain increases progressively from four days to adulthood. Oscillates diurnally in synaptic vesicles (at protein level). Mice begin to die 3 weeks after birth. They exhibit a progressive neurological phenotype including blindness, loss of coordination and enhanced startle response. Glutamatergic neurotransmission is drastically reduced due to a decrease in the reserve pool of synaptic vesicles and reduced quantal size. Visual signaling from photoreceptors to retinal output neurons is impaired while photoentrainment and pupillary light responses remain intact. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. Martineau M. et al. show that may function as a L- glutamate/H(+) antiporter (PubMed:29273736). However, according to Eriksen J. et al., H(+) is an allosteric activator (By similarity). neural retina development L-glutamate transmembrane transporter activity inorganic phosphate transmembrane transporter activity neurotransmitter transporter activity integral component of plasma membrane ion transport sodium ion transport phosphate ion transport neurotransmitter transport chemical synaptic transmission brain development long-term memory synaptic vesicle extracellular-glutamate-gated chloride channel activity symporter activity sodium:inorganic phosphate symporter activity sodium-dependent phosphate transmembrane transporter activity L-glutamate transport membrane integral component of membrane cell junction integral component of synaptic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle synaptic transmission, glutamatergic sodium ion transmembrane transport sequestering of neurotransmitter neuron projection intracellular organelle cerebellar mossy fiber sodium-dependent phosphate transport synapse presynaptic active zone regulation of synapse structure or activity response to stimulus L-glutamate import transmembrane transport excitatory synapse excitatory postsynaptic potential synaptic vesicle lumen acidification neurotransmitter loading into synaptic vesicle postsynapse regulation of synaptic vesicle endocytosis chloride transmembrane transport uc009gtx.1 uc009gtx.2 uc009gtx.3 uc009gtx.4 
ENSMUST00000085383.11 Scaf1 ENSMUST00000085383.11 SR-related CTD-associated factor 1, transcript variant 3 (from RefSeq NM_001400820.1) ENSMUST00000085383.1 ENSMUST00000085383.10 ENSMUST00000085383.2 ENSMUST00000085383.3 ENSMUST00000085383.4 ENSMUST00000085383.5 ENSMUST00000085383.6 ENSMUST00000085383.7 ENSMUST00000085383.8 ENSMUST00000085383.9 NM_001400820 Q3UR01 Q5U4C3 SFR19_MOUSE Sfrs19 uc009gsp.1 uc009gsp.2 uc009gsp.3 May function in pre-mRNA splicing. Interacts with POLR2A. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5U4C3-1; Sequence=Displayed; Name=2; IsoId=Q5U4C3-2; Sequence=VSP_027636, VSP_027637; Belongs to the splicing factor SR family. RNA binding nucleus transcription from RNA polymerase II promoter mRNA processing RNA splicing protein domain specific binding RNA polymerase II C-terminal domain binding uc009gsp.1 uc009gsp.2 uc009gsp.3 
ENSMUST00000085385.7 Ralgapa1 ENSMUST00000085385.7 Ral GTPase activating protein, alpha subunit 1, transcript variant 2 (from RefSeq NM_019994.5) ENSMUST00000085385.1 ENSMUST00000085385.2 ENSMUST00000085385.3 ENSMUST00000085385.4 ENSMUST00000085385.5 ENSMUST00000085385.6 Garnl1 Kiaa0884 NM_019994 Q6GYP6 Q6GYP7 Q6ZQ28 Q8BNJ5 Q8C9G8 Q8CIW4 Q9JMC4 RGPA1_MOUSE Tulip1 uc007nou.1 uc007nou.2 uc007nou.3 uc007nou.4 Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB (By similarity). May interact with the HLH region of TCF3/isoform E12. Component of the heterodimeric RalGAP1 complex with RALGAPB. Heterodimerization is required for activity (By similarity). Interacts with the HLH region of TCF3/isoform E12. Cytoplasm Nucleus Note=Translocated to the nucleus, when associated with TCF3/E12. Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=3; IsoId=Q6GYP7-1; Sequence=Displayed; Name=2; IsoId=Q6GYP7-2; Sequence=VSP_011338; Name=4; IsoId=Q6GYP7-3; Sequence=VSP_011332, VSP_011335; Name=5; IsoId=Q6GYP7-4; Sequence=VSP_011333, VSP_011334; Name=6; IsoId=Q6GYP7-5; Sequence=VSP_011331, VSP_011336, VSP_011337; Name=1S; IsoId=Q6GYP7-6; Sequence=VSP_011330; Expressed during embryogenesis. Expressed in the adult brain, particularly in neurons of the cortex and hippocampus. Expression decreased during development, but persists in the adult brain. [Isoform 1S]: May be a partial isoform 1. Was initially thought to act as a transcriptional regulator via its interaction with TCF3/E12. Sequence=BAA92774.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC98046.1; Type=Erroneous initiation; Evidence=; GTPase activator activity nucleus cytoplasm regulation of transcription, DNA-templated positive regulation of GTPase activity protein heterodimerization activity regulation of small GTPase mediated signal transduction activation of GTPase activity uc007nou.1 uc007nou.2 uc007nou.3 uc007nou.4 
ENSMUST00000085422.4 Izumo2 ENSMUST00000085422.4 IZUMO family member 2, transcript variant 1 (from RefSeq NM_029317.2) ENSMUST00000085422.1 ENSMUST00000085422.2 ENSMUST00000085422.3 IZUM2_MOUSE NM_029317 Q0P5Z2 Q9DA16 uc009gqk.1 uc009gqk.2 uc009gqk.3 uc009gqk.4 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DA16-1; Sequence=Displayed; Name=2; IsoId=Q9DA16-2; Sequence=VSP_037225; Name=3; IsoId=Q9DA16-3; Sequence=VSP_037224, VSP_037226; Izumo is the name of a Japanese shrine to marriage. Belongs to the Izumo family. Sequence=BAB24492.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; biological_process membrane integral component of membrane uc009gqk.1 uc009gqk.2 uc009gqk.3 uc009gqk.4 
ENSMUST00000085425.6 Isg15 ENSMUST00000085425.6 ISG15 ubiquitin-like modifier (from RefSeq NM_015783.3) ENSMUST00000085425.1 ENSMUST00000085425.2 ENSMUST00000085425.3 ENSMUST00000085425.4 ENSMUST00000085425.5 G1p2 ISG15_MOUSE NM_015783 Q64339 Q8K0H3 Ucrp uc012dri.1 uc012dri.2 uc012dri.3 Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, TRIM25, STAT5A, MAPK1/ERK2 and globin. Isgylation of the viral sensor IFIH1/MDA5 promotes IFIH1/MDA5 oligomerization and triggers activation of innate immunity against a range of viruses, including coronaviruses, flaviviruses and picornaviruses. Can also isgylate: RIGI which inhibits its function in antiviral signaling response, IRF3 which inhibits its ubiquitination and degradation as well as EIF4E2 which enhances its cap structure- binding activity and translation-inhibition activity. Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A and B virus, sindbis virus (SV) and herpes simplex type-1 (HHV-1). Plays a significant role in the control of neonatal Chikungunya virus (CHIKV) infection by acting as a putative immunomodulator of pro-inflammatory cytokines. Protects mice against the consequences of Chikungunya virus infection by down-regulating the pathogenic cytokine response, often denoted as the cytokine storm. Plays a role in erythroid differentiation. The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity. The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL (By similarity). Homodimer; disulfide-linked (By similarity). Interacts with, and is conjugated to its targets by the UBE1L (E1 enzyme) and UBE2E2 (E2 enzyme) (By similarity). Interacts with NEDD4 (By similarity). Q64339; Q9WTV6: Usp18; NbExp=4; IntAct=EBI-8345781, EBI-9119995; Q64339; PRO_0000422456 [K9N638]: 1a; Xeno; NbExp=2; IntAct=EBI-8345781, EBI-25635184; Q64339; PRO_0000338257 [P0C6U8]: 1a; Xeno; NbExp=3; IntAct=EBI-8345781, EBI-25635190; Q64339; PRO_0000037311 [P0C6X7]: rep; Xeno; NbExp=4; IntAct=EBI-8345781, EBI-25474079; Q64339; PRO_0000449621 [P0DTD1]: rep; Xeno; NbExp=5; IntAct=EBI-8345781, EBI-25492388; Cytoplasm Secreted Note=Exists in three distinct states: free within the cell, released into the extracellular space, or conjugated to target proteins. By type I interferons. Both the Ubiquitin-like 1 and Ubiquitin-like 2 domains are required for its efficient conjugation to cellular proteins. The two domains play different roles in the ISGylation pathway: Ubiquitin-like 2 domain is necessary for the first two steps allowing the linking of ISG15 to the E1 and E2 enzymes while Ubiquitin-like 1 domain is essential for the final, E3-mediated transfer of ISG15, from the E2 to the Lys of the target protein. S-nitrosylation decreases its dimerization, thereby increasing the availability as well as the solubility of monomeric ISG15 for its conjugation to cellular proteins. Induced as an inactive, precursor protein that is cleaved by specific proteases to expose the C-terminal diglycine (LRLRGG) motif. This motif is essential not only for its conjugation to substrates but also for its recognition by the relevant processing proteases (By similarity). Mass=17015; Method=MALDI; Evidence=; integrin binding protein binding extracellular region nucleus cytoplasm integrin-mediated signaling pathway response to bacterium modification-dependent protein catabolic process positive regulation of bone mineralization protein tag negative regulation of protein ubiquitination ubiquitin protein ligase binding ISG15-protein conjugation regulation of interferon-gamma production response to type I interferon defense response to bacterium negative regulation of viral genome replication positive regulation of erythrocyte differentiation defense response to virus interleukin-10 secretion interferon-gamma secretion protein ubiquitination uc012dri.1 uc012dri.2 uc012dri.3 
ENSMUST00000085435.7 Csnk1g2 ENSMUST00000085435.7 casein kinase 1, gamma 2, transcript variant 2 (from RefSeq NM_001159591.1) Ck1g2 ENSMUST00000085435.1 ENSMUST00000085435.2 ENSMUST00000085435.3 ENSMUST00000085435.4 ENSMUST00000085435.5 ENSMUST00000085435.6 KC1G2_MOUSE NM_001159591 Q8BVP5 uc007geb.1 uc007geb.2 uc007geb.3 uc007geb.4 Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates MTA1 (PubMed:15077195). Phosphorylates COL4A3BP/CERT and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine- repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (By similarity). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (PubMed:16014721). Involved in regulation of reactive oxygen species (ROS) levels (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Stimulated by estrogen. Monomer (By similarity). Interacts with MTA1 (short isoform) in the cytoplasm (PubMed:15077195). Interacts with SMAD3 (By similarity). Interacts with DUOXA2 (By similarity). Cytoplasm, cell cortex Cytoplasm Expressed in both the striatum and the neocortex. The phospho-regulated basic and hydrophobic (PRBH) motif is sufficient and important for interaction with phospholipids permitting cortical localization. Phosphorylation of the PRBH motif by aPKC inhibits the association of the protein with the cortical membrane. Autophosphorylated. Phosphorylated by aPKC which promotes dissociation from the cell cortex. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm plasma membrane protein phosphorylation Wnt signaling pathway kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation protein autophosphorylation positive regulation of canonical Wnt signaling pathway uc007geb.1 uc007geb.2 uc007geb.3 uc007geb.4 
ENSMUST00000085450.4 Klk1b3 ENSMUST00000085450.4 kallikrein 1-related peptidase b3 (from RefSeq NM_008693.2) A2RTW1 ENSMUST00000085450.1 ENSMUST00000085450.2 ENSMUST00000085450.3 K1KB3_MOUSE Klk-3 Klk3 NM_008693 Ngfg P00756 uc009gol.1 uc009gol.2 uc009gol.3 uc009gol.4 This gene encodes the gamma subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. The encoded protein is a glandular kallikrein-type serine protease that processes the beta subunit of NGF. This gene is present in a cluster of multiple related kallikrein-type protease genes on chromosome 7. [provided by RefSeq, Jul 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC132657.1, X01389.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## 7S NGF alpha chain stabilizes the 7S complex. The beta dimer promotes neurite growth. The gamma chain is an arginine-specific protease; it may also have plasminogen activator activity, as well as mitogenic activity for chick embryo fibroblasts. Reaction=Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl- bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|- Xaa.; EC=3.4.21.35; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per 7S complex. The Zn(2+) ions are bound at the alpha-gamma interfaces.; 7S nerve growth factor is composed of two alpha chains, a beta dimer composed of identical chains, and two gamma chains. This precursor is cleaved into segments to produce the active form of the gamma chain, which occurs naturally as combinations of either two or three segments held together by disulfide bonds: B1 and A, or B1, C and B2. Belongs to the peptidase S1 family. Kallikrein subfamily. regulation of systemic arterial blood pressure endopeptidase activity serine-type endopeptidase activity extracellular space proteolysis signal transduction growth factor activity peptidase activity serine-type peptidase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides secretory granule zymogen activation macromolecular complex metal ion binding uc009gol.1 uc009gol.2 uc009gol.3 uc009gol.4 
ENSMUST00000085453.6 Rasl12 ENSMUST00000085453.6 RAS-like, family 12, transcript variant 1 (from RefSeq NM_001033158.2) ENSMUST00000085453.1 ENSMUST00000085453.2 ENSMUST00000085453.3 ENSMUST00000085453.4 ENSMUST00000085453.5 NM_001033158 Q08AT1 Q3TAU9 RASLC_MOUSE uc009qdf.1 uc009qdf.2 uc009qdf.3 uc009qdf.4 uc009qdf.5 Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Belongs to the small GTPase superfamily. Ras family. nucleotide binding GTPase activity calmodulin binding GTP binding plasma membrane signal transduction Ras protein signal transduction membrane GDP binding uc009qdf.1 uc009qdf.2 uc009qdf.3 uc009qdf.4 uc009qdf.5 
ENSMUST00000085455.6 Klk1b21 ENSMUST00000085455.6 kallikrein 1-related peptidase b21 (from RefSeq NM_010642.4) ENSMUST00000085455.1 ENSMUST00000085455.2 ENSMUST00000085455.3 ENSMUST00000085455.4 ENSMUST00000085455.5 K1B21_MOUSE Klk-21 Klk21 NM_010642 Q61759 Q61760 Q9JM70 uc009goh.1 uc009goh.2 uc009goh.3 uc009goh.4 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC012243.1, AB039276.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Displays trypsin-like substrate specificity and shows activity towards casein, gelatin, fibronectin and IGFBP3. Reaction=Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl- bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|- Xaa.; EC=3.4.21.35; Evidence=; Inhibited by protease inhibitors diisopropylfluorophosphate, leupeptin, antipain, benzamidine, phenylmethylsulfonyl fluoride and soybean trypsin inhibitor. Expressed in testis and submaxillary gland. In the testis, expression localized specifically to Leydig cells in the interstitial tissues. Detectable in testis 4 weeks after birth, becoming more prominent thereafter. By T protein. Belongs to the peptidase S1 family. Kallikrein subfamily. regulation of systemic arterial blood pressure endopeptidase activity serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides secretory granule zymogen activation macromolecular complex uc009goh.1 uc009goh.2 uc009goh.3 uc009goh.4 
ENSMUST00000085461.4 Klk8 ENSMUST00000085461.4 kallikrein related-peptidase 8, transcript variant 1 (from RefSeq NM_008940.3) ENSMUST00000085461.1 ENSMUST00000085461.2 ENSMUST00000085461.3 KLK8_MOUSE NM_008940 Nrpn Prss19 Q61955 Q8K5D7 uc009gns.1 uc009gns.2 uc009gns.3 uc009gns.4 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein exhibit impaired long-term potentiation and increased anxiety, as well as a hyperkeratosis phenotype. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D30785.1, AB981040.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. Reaction=Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys.; EC=3.4.21.118; Strongly inhibited by diisopropyl fluorophosphate, leupeptin and (4-amidinophenyl)methanesulfonyl 1-fluoride. Kinetic parameters: KM=300 uM for Boc-Val-Pro-Arg-MCA ; KM=540 uM for Boc-Phe-Ser-Arg-MCA ; KM=280 uM for D-Val-Leu-Arg-MCA ; Interacts with SPINK9. Secreted. Cytoplasm. Note=Shows a cytoplasmic distribution in the keratinocytes. Expressed in the limbic system of mouse brain and is localized at highest concentration in pyramidal neurons of the hippocampal CA1-3 subfields. Also detected in spinal cord gray matter and in keratinized stratified epithelia of epidermis, hair, tongue, palate, nasal cavity, pharynges, esophagus and forestomach. In skin and mucus membranes, expressed in stratum spinosum and stratum granulosum. Expressed during estrus in vaginal epithelial cells but not stromal cells. Within the vaginal epithelium, expressed in prickle cells, granular cells and parakeratotic cells but not in basal cells. Not expressed in uterus. Expressed in the keratinocytes. Expression is detected in the brain from embryonic day 12 and continues into adulthood. By chemical/incision-induced brain injury which leads to increased expression in axon fiber bundles of the peri-lesioned region, by electrically-induced seizure (kindling) in brain, by UV irradiation in skin and by incisional and chemically-induced skin wounding which causes epidermal proliferation and hyperkeratosis. Induced by chemically-induced oxidative stress which leads to increased expression in the hippocampal pyramidal neurons 2 hours after treatment. Levels then decrease, drop to 60% of pretreated control levels at day 7 when avoidance learning is impaired and return to control levels at day 30. Also induced by spinal crush injury which leads to increased expression in spinal cord white matter adjacent to the lesion. Expression increases between days 1-14 post-injury with a peak at day 4. Mass=26229; Method=MALDI; Evidence=; Mice display marked abnormalities of synapses and neurons in the CA1 subfield of the hippocampus with enlarged and elongated pyramidal cell soma and reduced asymmetrical synapse numbers. Mutants also display impaired spatial memory acquisition, increased hippocampal susceptibility to hyperexcitability in response to repetitive afferent stimulation and prolonged recovery of UV-irradiated skin. Following spinal cord injury, mutants display reduced demyelination, oligodendrocyte death and axonal degeneration, and inproved hind limb recovery, suggesting that attenuation of neuropsin activity may be beneficial in the treatment of spinal cord injury. Blocking of Klk8 activity by intraventricular injection with monoclonal antibodies reduces or eliminates epileptic seizures in kindled mice. Belongs to the peptidase S1 family. Kallikrein subfamily. serine-type endopeptidase activity extracellular region extracellular space cytoplasm proteolysis memory cell death peptidase activity serine-type peptidase activity response to wounding hydrolase activity secretory granule negative regulation of myelination keratinocyte proliferation negative regulation of axon regeneration neuron projection morphogenesis regulation of synapse organization synapse organization serine protease inhibitor complex uc009gns.1 uc009gns.2 uc009gns.3 uc009gns.4 
ENSMUST00000085513.6 Uri1 ENSMUST00000085513.6 URI1, prefoldin-like chaperone, transcript variant 1 (from RefSeq NM_011274.6) ENSMUST00000085513.1 ENSMUST00000085513.2 ENSMUST00000085513.3 ENSMUST00000085513.4 ENSMUST00000085513.5 NM_011274 Nnx3 Ppp1r19 Q3TLD5 Q3V078 Q8R5C4 Q9Z243 RMP_MOUSE Rmp Uri uc009gkp.1 uc009gkp.2 uc009gkp.3 uc009gkp.4 Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region (By similarity). Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient- sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination (By similarity). Homodimer. Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92. Interacts with POLR2E/RPB5, RUVBL2 and RUVBL1. Interacts with PFDN2, PFDN4 and STAP1; the interactions are phosphorylation-dependent and occur in a growth-dependent manner in the mitochondrion. Interacts with UXT. Interacts with PPP1CC; the interaction is phosphorylation-dependent and occurs in a growth factor- dependent manner. Interacts (via the middle C-terminal region) with GTF2F1 and GTF2F2. Interacts with DMAP1. Interacts with TSC1 and TSC2. Interacts with PRPF8 and EFTUD2 in a ZNHIT2-dependent manner. Nucleus Cytoplasm Mitochondrion Cell projection, dendrite Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 in mitochondrion. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TLD5-1; Sequence=Displayed; Name=2; IsoId=Q3TLD5-2; Sequence=VSP_032774; Expressed in the spinal cord, ganglia, choroid plexus and olfactors epithelium of the developing brain. Expressed in skin, lung, kidney, testis and muscles (at protein level). Expressed strongly in brain and kidney. Expressed weakly in skeletal muscle, lung and liver. Expressed in embryo at 6 dpc, onward. Phosphorylation occurs in response to androgen treatment in prostate cancer cells in a mTOR-dependent manner. Phosphorylated; hyperhosphorylated in mitochondria in a mTORC-dependent signaling pathway. Phosphorylated at Ser-369 by RPS6KB1 in a growth factor- and rapamycin-dependent manner. S6K1-mediated mitochondrial phosphorylation at Ser-369 disrupts the URI1-PPP1CC complex in the mitochondrion, relieves PPP1CC phosphatase inhibition activity and hence engages a negative feedback diminishing RPS6KB1 kinase activity, preventing sustained S6K1-dependent signaling (By similarity). Phosphorylated. Phosphorylation occurs essentially on serine residues. Belongs to the RNA polymerase II subunit 5-mediating protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core binding regulation of cell growth chromatin binding transcription corepressor activity protein phosphatase inhibitor activity nucleus nucleoplasm cytoplasm mitochondrion cytosol regulation of transcription from RNA polymerase II promoter response to virus negative regulation of phosphatase activity phosphatase inhibitor activity dendrite negative regulation of phosphoprotein phosphatase activity cell projection phosphoprotein binding cellular response to growth factor stimulus cellular response to steroid hormone stimulus negative regulation of intrinsic apoptotic signaling pathway uc009gkp.1 uc009gkp.2 uc009gkp.3 uc009gkp.4 
ENSMUST00000085519.13 Anp32a ENSMUST00000085519.13 acidic nuclear phosphoprotein 32 family member A, transcript variant 1 (from RefSeq NM_009672.4) AN32A_MOUSE Anp32 ENSMUST00000085519.1 ENSMUST00000085519.10 ENSMUST00000085519.11 ENSMUST00000085519.12 ENSMUST00000085519.2 ENSMUST00000085519.3 ENSMUST00000085519.4 ENSMUST00000085519.5 ENSMUST00000085519.6 ENSMUST00000085519.7 ENSMUST00000085519.8 ENSMUST00000085519.9 Lanp NM_009672 O35381 P97437 uc009qah.1 uc009qah.2 uc009qah.3 uc009qah.4 uc009qah.5 uc009qah.6 Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP- associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:29467488). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (By similarity) (PubMed:17557114, PubMed:29467488). Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B. Interacts with ELAVL1. Part of the INHAT (inhibitor of histone acetyltransferases) complex. Interacts with E4F1. O35381; Q8CCE9: E4f1; NbExp=2; IntAct=EBI-643140, EBI-7450874; Nucleus Cytoplasm Endoplasmic reticulum Note=Shuttles between nucleus and cytoplasm. Translocates to the cytoplasm during the process of neuritogenesis. Predominantly expressed in the cerebellum. Expressed also in cortex, lung, skeletal muscle, gastrointestinal tract, spleen, liver and heart. Phosphorylated on serine residues, at least in part by casein kinase 2/CK2. Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group. Mice are viable and fertile. They have no derangements in any of the major organ systems, including the nervous systems. Moreover, bone marrow cells from mutant mice only show mild decrease of colony-forming unit(CFU)-myeloid. Belongs to the ANP32 family. protein binding nucleus cytoplasm endoplasmic reticulum nucleocytoplasmic transport nuclear matrix histone binding perinuclear region of cytoplasm uc009qah.1 uc009qah.2 uc009qah.3 uc009qah.4 uc009qah.5 uc009qah.6 
ENSMUST00000085546.13 Hmgb1 ENSMUST00000085546.13 high mobility group box 1, transcript variant 2 (from RefSeq NM_010439.4) ENSMUST00000085546.1 ENSMUST00000085546.10 ENSMUST00000085546.11 ENSMUST00000085546.12 ENSMUST00000085546.2 ENSMUST00000085546.3 ENSMUST00000085546.4 ENSMUST00000085546.5 ENSMUST00000085546.6 ENSMUST00000085546.7 ENSMUST00000085546.8 ENSMUST00000085546.9 Hmgb1 NM_010439 Q58EV5 Q58EV5_MOUSE uc009apd.1 uc009apd.2 uc009apd.3 uc009apd.4 uc009apd.5 This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]. Chromosome Endoplasmic reticulum-Golgi intermediate compartment Nucleus Belongs to the HMGB family. four-way junction DNA binding bubble DNA binding DNA binding nucleus DNA binding, bending DNA geometric change supercoiled DNA binding uc009apd.1 uc009apd.2 uc009apd.3 uc009apd.4 uc009apd.5 
ENSMUST00000085553.13 Grhl1 ENSMUST00000085553.13 grainyhead like transcription factor 1, transcript variant 1 (from RefSeq NM_001161406.1) ENSMUST00000085553.1 ENSMUST00000085553.10 ENSMUST00000085553.11 ENSMUST00000085553.12 ENSMUST00000085553.2 ENSMUST00000085553.3 ENSMUST00000085553.4 ENSMUST00000085553.5 ENSMUST00000085553.6 ENSMUST00000085553.7 ENSMUST00000085553.8 ENSMUST00000085553.9 GRHL1_MOUSE Grhl1 Mgr NM_001161406 Q8K5C1 Q921D9 Tcfcp2l2 uc007nem.1 uc007nem.2 uc007nem.3 uc007nem.4 Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:18288204, PubMed:21081122). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier (PubMed:18288204, PubMed:24586629). There is no genetic interaction with GRHL3, nor functional cooperativity due to diverse target gene selectivity during epithelia development (PubMed:21081122). May play a role in regulating glucose homeostasis and insulin signaling. Binds DNA as homodimer. Homodimer, also forms heterodimers with GRHL2 or GRHL3. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=p70 Mgr; IsoId=Q921D9-1; Sequence=Displayed; Name=2; Synonyms=p61 Mgr; IsoId=Q921D9-2; Sequence=VSP_017641, VSP_017640; Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Expression in the skin is confined to the suprabasal layers of the epidermis and to the hair follicles. At 15.5 dpc isoform 1 is expressed predominantly in the skin and in the developing hair germ, isoform 2 is expressed predominantly in the epidermis. Methylation at Arg-9 and Lys-116 may be involved in regulating transcriptional activation. Mutants are healthy and fertile, but display an initial delay in coat growth, with older mice exhibiting hair loss as a result of poor anchoring or the hair shaft in the follicle. They show reduced numbers of abnormal desmosomes in the interfollicular epidermis. Develop palmoplantar keratoderma (PubMed:21081122). They also exhibit mild chronic skin barrier defects with altered keratinocyte terminal differentiation, increased expression of inflammatory markers and infiltration of the skin by immune cells. GRHL genes (GRHL1, GRHL2 and GRHL3) show a paradoxical lack of redundancy despite their extensive sequence identity in the DNA-binding and protein dimerization domains and the fact that the core consensus DNA binding sites are identical. They have related but remarkably different functions during embryogenesis because of their differential spatiotemporal expression patterns during development. Belongs to the grh/CP2 family. Grainyhead subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding desmosome organization DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm Golgi apparatus cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development epidermis development chromatin DNA binding protein homodimerization activity intracellular membrane-bounded organelle sequence-specific DNA binding transcription regulatory region DNA binding regulation of keratinocyte differentiation positive regulation of transcription from RNA polymerase II promoter establishment of skin barrier uc007nem.1 uc007nem.2 uc007nem.3 uc007nem.4 
ENSMUST00000085555.7 Utp25 ENSMUST00000085555.7 UTP25 small subunit processome component, transcript variant 1 (from RefSeq NM_145415.3) A0A0R4J114 A0A0R4J114_MOUSE Diexf ENSMUST00000085555.1 ENSMUST00000085555.2 ENSMUST00000085555.3 ENSMUST00000085555.4 ENSMUST00000085555.5 ENSMUST00000085555.6 NM_145415 Utp25 uc007edw.1 uc007edw.2 uc007edw.3 Nucleus, nucleolus Belongs to the UTP25 family. nucleus nucleolus protein catabolic process protein destabilization uc007edw.1 uc007edw.2 uc007edw.3 
ENSMUST00000085585.12 Lsm14a ENSMUST00000085585.12 LSM14A mRNA processing body assembly factor, transcript variant 1 (from RefSeq NM_025948.3) ENSMUST00000085585.1 ENSMUST00000085585.10 ENSMUST00000085585.11 ENSMUST00000085585.2 ENSMUST00000085585.3 ENSMUST00000085585.4 ENSMUST00000085585.5 ENSMUST00000085585.6 ENSMUST00000085585.7 ENSMUST00000085585.8 ENSMUST00000085585.9 Fam61a LS14A_MOUSE NM_025948 Q8K2F8 Q9CTG8 Rap55a uc009gjd.1 uc009gjd.2 uc009gjd.3 uc009gjd.4 Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly. Component of a ribonucleoprotein (RNP) complex (By similarity). Interacts with DDX6. Interacts with EIF4ENIF1/4E-T; promoting EIF4ENIF1/4E-T localization to P-bodies. Interacts (via FFD box) with EDC4 (By similarity). Cytoplasm, P-body Cytoplasm, cytoskeleton, spindle Cytoplasm, Stress granule The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention. Belongs to the LSM14 family. P-body double-stranded DNA binding double-stranded RNA binding single-stranded RNA binding cytoplasm cytosol regulation of translation multicellular organism development cytoplasmic stress granule cytoplasmic mRNA processing body assembly cytoplasmic ribonucleoprotein granule RIG-I signaling pathway defense response to virus positive regulation of type I interferon-mediated signaling pathway uc009gjd.1 uc009gjd.2 uc009gjd.3 uc009gjd.4 
ENSMUST00000085591.7 Pdx1 ENSMUST00000085591.7 pancreatic and duodenal homeobox 1 (from RefSeq NM_008814.4) ENSMUST00000085591.1 ENSMUST00000085591.2 ENSMUST00000085591.3 ENSMUST00000085591.4 ENSMUST00000085591.5 ENSMUST00000085591.6 Ipf1 NM_008814 P52946 PDX1_MOUSE Q3ZB03 uc009any.1 uc009any.2 uc009any.3 uc009any.4 Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'. Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with the methyltransferase SETD7 (By similarity). Interacts with SPOP. Part of a PDX1:PBX1b:MEIS2b complex. P52946; P13405: Rb1; NbExp=2; IntAct=EBI-7128945, EBI-971782; P52946; Q6ZWS8: Spop; NbExp=5; IntAct=EBI-7128945, EBI-7128920; Nucleus toplasm, cytosol Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). At 8.5 dpc, detected in the gut epithelium from which the pancreatic buds are formed. Transient expression in pancreatic ducts, endocrine and acinar cells. Down-regulated around 10.5 dpc when expression becomes restricted to differentiated beta- cells. Expression is repressed by FOXO1 in pancreatic beta-cells. The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter. The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein- protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y). Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-269 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol. Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding liver development type B pancreatic cell differentiation DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol glucose metabolic process transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter smoothened signaling pathway nitric oxide mediated signal transduction multicellular organism development central nervous system development transcription factor binding positive regulation of cell proliferation negative regulation of cell proliferation response to wounding response to glucose response to iron(II) ion response to chlorate animal organ senescence regulation of gene expression positive regulation of cell death response to organic cyclic compound morphogenesis of embryonic epithelium nuclear speck insulin secretion cell differentiation pancreas development exocrine pancreas development endocrine pancreas development animal organ regeneration response to nutrient levels positive regulation of insulin secretion response to vitamin response to lipid response to cytokine response to nicotine positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of cell proliferation response to drug glucose homeostasis response to leucine response to alkaloid positive regulation of DNA binding sequence-specific DNA binding macromolecular complex binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity digestive tract development stem cell differentiation response to glucocorticoid detection of glucose transdifferentiation response to fatty acid negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway promoter-specific chromatin binding negative regulation of type B pancreatic cell apoptotic process uc009any.1 uc009any.2 uc009any.3 uc009any.4 
ENSMUST00000085614.6 Usp12 ENSMUST00000085614.6 ubiquitin specific peptidase 12 (from RefSeq NM_011669.3) ENSMUST00000085614.1 ENSMUST00000085614.2 ENSMUST00000085614.3 ENSMUST00000085614.4 ENSMUST00000085614.5 NM_011669 Q790B0 Q7TNV4 Q80Y43 Q8CBN8 Q9D9M2 UBP12_MOUSE Ubh1 uc009anj.1 uc009anj.2 uc009anj.3 Deubiquitinating enzyme that plays various roles in the regulation of the immune response and inflammation. In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability. During TCR engagement and activation, translocates into the cytoplasm and deubiquitinates its substrates LAT and TRAT1 and prevents their lysosome-dependent degradation to stabilize the TCR signaling complex at the plasma membrane. Plays an essential role in the selective LPS-induced macrophage response through the activation of NF-kappa-B pathway. In addition, promotes that antiviral immune response through targeting DNA sensor IFI16 to inhibit its proteasome- dependent degradation. Participates in the interferon signaling pathway and antiviral response independently of its deubiquitinase activity by maintaining nuclear phosphorylated STAT1 levels via inhibition of its CREBBP-mediated acetylation and subsequent dephosphorylation (By similarity). Plays an intrinsic role in promoting the differentiation, activation and proliferation of CD4(+) T-cell by activating the NF- kappa-B signaling pathway through deubiquitinating and stabilizing B- cell lymphoma/leukemia 10/BCL10 (PubMed:33941870). In myeloid-derived suppressor cells promotes the activation of the NF-kappa-B via deubiquitination and stabilization of RELA (PubMed:35898171). Regulates the 'Lys-63'-linked polyubiquitin chains of BAX and thereby modulates the mitochondrial apoptotic process (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Activated by interaction with WDR20; WDR48 and DMWD through different allosteric mechanisms. Interacts with WDR48. Interacts with WDR20; this interaction promotes translocation of the USP12 complex to the plasma membrane. Component of the USP12/WDR20/WDR48 deubiquitinating complex. Component of the USP12/DMWD/WDR48 deubiquitinating complex. Interacts with PHLPP1. Interacts with RBPJ. Interacts with CBP; this interaction blocks the acetyltransferase activity of CREBBP. Nucleus Cytoplasm Cell membrane Note=Translocates from the nucleus to the cytosol on TCR stimulation, while it translocates into the nucleus in IFN signaling. USP12/WDR20/WDR48 complex is localized mainly to the plasma membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D9M2-1; Sequence=Displayed; Name=2; IsoId=Q9D9M2-2; Sequence=VSP_037617; USP12-deficiency attenuates CD4(+) T-cell activation (PubMed:33941870). In addition, USP12 mutant mice show significantly reduced tumor growth when compared to WT mice. Both the frequency and number of CD4(+) or CD8(+) T-cells isolated from the tumor are significantly higher in the USP12-deletion mutant mice (PubMed:35898171). Belongs to the peptidase C19 family. USP12/USP46 subfamily. cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus cytosol proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity metal ion binding positive regulation of T cell receptor signaling pathway ubiquitinyl hydrolase activity uc009anj.1 uc009anj.2 uc009anj.3 
ENSMUST00000085618.5 Scgb1b27 ENSMUST00000085618.5 secretoglobin, family 1B, member 27 (from RefSeq NM_009596.2) Abpa Abpa27 ENSMUST00000085618.1 ENSMUST00000085618.2 ENSMUST00000085618.3 ENSMUST00000085618.4 NM_009596 Q91WB5 Q91WB5_MOUSE Scgb1b27 uc009giq.1 uc009giq.2 uc009giq.3 Secreted steroid binding extracellular region cytoplasm biological_process uc009giq.1 uc009giq.2 uc009giq.3 
ENSMUST00000085620.9 Scgb2b27 ENSMUST00000085620.9 secretoglobin, family 2B, member 27, transcript variant 1 (from RefSeq NM_001100464.2) Abpb Abpbg27 C2a ENSMUST00000085620.1 ENSMUST00000085620.2 ENSMUST00000085620.3 ENSMUST00000085620.4 ENSMUST00000085620.5 ENSMUST00000085620.6 ENSMUST00000085620.7 ENSMUST00000085620.8 NM_001100464 Q8R1E9 Q8R1E9_MOUSE Scgb2b27 uc009gip.1 uc009gip.2 uc009gip.3 uc009gip.4 uc009gip.5 Secreted Belongs to the secretoglobin family. molecular_function extracellular region extracellular space biological_process uc009gip.1 uc009gip.2 uc009gip.3 uc009gip.4 uc009gip.5 
ENSMUST00000085623.4 Scgb2b26 ENSMUST00000085623.4 secretoglobin, family 2B, member 26 (from RefSeq NM_178308.2) Abpbg26 Abpg C2d ENSMUST00000085623.1 ENSMUST00000085623.2 ENSMUST00000085623.3 NM_178308 Q8JZX1 Q8JZX1_MOUSE Scgb2b26 uc009gio.1 uc009gio.2 uc009gio.3 uc009gio.4 Secreted Belongs to the secretoglobin family. molecular_function extracellular region extracellular space biological_process uc009gio.1 uc009gio.2 uc009gio.3 uc009gio.4 
ENSMUST00000085635.6 Flvcr1 ENSMUST00000085635.6 feline leukemia virus subgroup C cellular receptor 1, transcript variant 2 (from RefSeq NM_001313747.1) B2RXV4 ENSMUST00000085635.1 ENSMUST00000085635.2 ENSMUST00000085635.3 ENSMUST00000085635.4 ENSMUST00000085635.5 FLVC1_MOUSE Mfsd7b NM_001313747 uc007ebv.1 uc007ebv.2 uc007ebv.3 [Isoform 1]: Heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies. Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated. [Isoform 2]: Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. [Isoform 1]: Reaction=heme b(in) = heme b(out); Xref=Rhea:RHEA:75443, ChEBI:CHEBI:60344; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75444; Evidence=; [Isoform 2]: Reaction=heme b(in) = heme b(out); Xref=Rhea:RHEA:75443, ChEBI:CHEBI:60344; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75444; Evidence=; Interacts with HPX. [Isoform 1]: Cell membrane ; Multi-pass membrane protein [Isoform 2]: Mitochondrion membrane ; Multi-pass membrane protein Note=Colocalizes with HADHA. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Flvcr1a ; IsoId=B2RXV4-1; Sequence=Displayed; Name=2; Synonyms=Flvcr1b, mitochondrial ; IsoId=B2RXV4-2; Sequence=VSP_047867; N-Glycosylated. Lack definitive erythropoiesis, have craniofacial and limb deformities, and die in midgestation. Mice with FLVCR1 that is deleted neonatally develop a severe macrocytic anemia with proerythroblast maturation arrest. Mice lacking the plasma membrane isoform (Flvcr1a) but expressing Flvcr1b had normal erythropoiesis, but exhibited hemorrhages, edema, and skeletal abnormalities. [Isoform 2]: Has a probable mitochondrial transit peptide at positions 1-38. Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family. blood vessel development in utero embryonic development mitochondrion plasma membrane integral component of plasma membrane mitochondrial transport heme transporter activity heme transport membrane integral component of membrane heme binding erythrocyte differentiation mitochondrial membrane limb morphogenesis multicellular organism growth embryonic digit morphogenesis erythrocyte maturation regulation of organ growth spleen development embryonic skeletal system morphogenesis transmembrane transport head morphogenesis heme export uc007ebv.1 uc007ebv.2 uc007ebv.3 
ENSMUST00000085658.5 Insyn1 ENSMUST00000085658.5 inhibitory synaptic factor 1 (from RefSeq NM_176921.4) ENSMUST00000085658.1 ENSMUST00000085658.2 ENSMUST00000085658.3 ENSMUST00000085658.4 INSY1_MOUSE NM_176921 Q8CD60 uc009pwz.1 uc009pwz.2 Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. Interacts with GPHN. Postsynaptic density Belongs to the INSYN1 family. protein binding plasma membrane postsynaptic density membrane cell junction synapse postsynaptic membrane inhibitory postsynaptic potential uc009pwz.1 uc009pwz.2 
ENSMUST00000085671.10 Zkscan5 ENSMUST00000085671.10 zinc finger with KRAB and SCAN domains 5, transcript variant 1 (from RefSeq NM_016683.3) E9QLY2 ENSMUST00000085671.1 ENSMUST00000085671.2 ENSMUST00000085671.3 ENSMUST00000085671.4 ENSMUST00000085671.5 ENSMUST00000085671.6 ENSMUST00000085671.7 ENSMUST00000085671.8 ENSMUST00000085671.9 NM_016683 Q9Z1D8 ZKSC5_MOUSE Zfp95 uc009amn.1 uc009amn.2 uc009amn.3 uc009amn.4 May be involved in transcriptional regulation. Nucleus Testis specific. Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009amn.1 uc009amn.2 uc009amn.3 uc009amn.4 
ENSMUST00000085673.11 Pml ENSMUST00000085673.11 promyelocytic leukemia, transcript variant 2 (from RefSeq NM_178087.5) ENSMUST00000085673.1 ENSMUST00000085673.10 ENSMUST00000085673.2 ENSMUST00000085673.3 ENSMUST00000085673.4 ENSMUST00000085673.5 ENSMUST00000085673.6 ENSMUST00000085673.7 ENSMUST00000085673.8 ENSMUST00000085673.9 NM_178087 PML_MOUSE Q60953 Q8CEJ1 Q8VCC4 uc009pwp.1 uc009pwp.2 uc009pwp.3 uc009pwp.4 uc009pwp.5 Functions via its association with PML-nuclear bodies (PML- NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (By similarity). Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum. Regulates RB1 phosphorylation and activity. Acts as both a negative regulator of PPARGC1A acetylation and a potent activator of PPAR signaling and fatty acid oxidation. Regulates translation of HIF1A by sequestering MTOR, and thereby plays a role in neoangiogenesis and tumor vascularization. Regulates PER2 nuclear localization and circadian function. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. Required for normal development of the brain cortex during embryogenesis. Plays a role in granulopoiesis or monopoiesis of myeloid progenitor cells. May play a role regulating stem and progenitor cell fate in tissues as diverse as blood, brain and breast. Shows antiviral activity towards lymphocytic choriomeningitis virus (LCMV) and the vesicular stomatitis virus (VSV). Key component of PML bodies. PML bodies are formed by the interaction of PML homodimers (via SUMO-binding motif) with sumoylated PML, leading to the assembly of higher oligomers. Several types of PML bodies have been observed. PML bodies can form hollow spheres that can sequester target proteins inside. Interacts (via SUMO-binding motif) with sumoylated proteins. Interacts (via C-terminus) with p53/TP53. Recruits p53/TP53 and CHEK2 into PML bodies, which promotes p53/TP53 phosphorylation at 'Ser-20' and prevents its proteasomal degradation. Interacts with MDM2, and sequesters MDM2 in the nucleolus, thereby preventing ubiquitination of p53/TP53. Interaction with PML-RARA oncoprotein and certain viral proteins causes disassembly of PML bodies and abolishes the normal PML function. Interacts with TERT, SIRT1, TOPBP1, TRIM27 and TRIM69. Interacts with ELF4 (via C-terminus). Interacts with Lassa virus Z protein and rabies virus phosphoprotein. Interacts (in the cytoplasm) with TGFBR1, TGFBR2 and PKM. Interacts (via the coiled-coil domain and when sumoylated) with SATB1. Interacts with UBE2I; the interaction is enhanced by arsenic binding. Interacts with SMAD2, SMAD3, DAXX, RPL11, HIPK2 and MTOR. Interacts with ITPR3, PPP1A and RB1. Interacts with RNF4, NLRP3, MAGEA2, RBL2, PER2, E2F4 and MAPK7/BMK1. Interacts with CSNK2A1 and CSNK2A3. Interacts with ANKRD2; the interaction is direct. Interacts with PPARGC1A and KAT2A. Interacts (via SUMO-interacting motif) with sumoylated MORC3 (By similarity). Interacts with TRIM16. Interacts with PRDM1 (By similarity). Interacts (via RING-type zinc finger) with EIF4E; the interaction reduces EIF4E affinity for the 5' m7G cap of mRNA, thus reducing nuclear export of cyclin CCND1 (PubMed:11500381, PubMed:11575918). Q60953; P25446: Fas; NbExp=6; IntAct=EBI-3895605, EBI-296206; Q60953; Q505F1: Nr2c1; NbExp=2; IntAct=EBI-3895605, EBI-15617004; Q60953; O54943: Per2; NbExp=4; IntAct=EBI-3895605, EBI-1266779; Q60953; Q60979: Skil; NbExp=5; IntAct=EBI-3895605, EBI-7213804; Q60953; Q8UN00: gag-pro-pol; Xeno; NbExp=4; IntAct=EBI-3895605, EBI-6692904; Q60953; Q16236: NFE2L2; Xeno; NbExp=2; IntAct=EBI-3895605, EBI-2007911; Q60953-2; Q14DJ8: Axin1; NbExp=4; IntAct=EBI-4406901, EBI-4312125; Nucleus Nucleus, nucleoplasm. Cytoplasm. Nucleus, PML body. Nucleus, nucleolus Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Detected in the nucleolus after DNA damage. Acetylation at Lys-497 is essential for its nuclear localization. Within the nucleus, most of PML is expressed in the diffuse nuclear fraction of the nucleoplasm and only a small fraction is found in the matrix-associated nuclear bodies (PML-NBs). The transfer of PML from the nucleoplasm to PML-NBs depends on its phosphorylation and sumoylation. The B1 box and the RING finger are also required for the localization in PML-NBs. Also found in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60953-1; Sequence=Displayed; Name=2; IsoId=Q60953-2; Sequence=VSP_026028; The coiled-coil domain mediates a strong homo/multidimerization activity essential for core assembly of PML-NBs. Binds arsenic via the RING-type zinc finger. The Sumo interaction motif (SIM) is required for efficient ubiquitination, recruitment of proteasome components within PML-NBs and PML degradation in response to arsenic trioxide. Ubiquitinated; mediated by RNF4, RNF111, UHRF1, UBE3A/E6AP, BCR(KLHL20) E3 ubiquitin ligase complex, SIAH1 or SIAH2 and leading to subsequent proteasomal degradation. 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4 is polysumoylation-dependent (By similarity). Ubiquitination by RNF111 is polysumoylation-dependent (PubMed:23530056). Ubiquitination by BCR(KLHL20) E3 ubiquitin ligase complex requires CDK1/2-mediated phosphorylation at Ser-528 which in turn is recognized by prolyl-isopeptidase PIN1 and PIN1-catalyzed isomerization further potentiates PML interaction with KLHL20 (By similarity). Sumoylation regulates PML's: stability in response to extracellular or intracellular stimuli, transcription directly and indirectly, through sequestration of or dissociation of the transcription factors from PML-NBs, ability to regulate apoptosis and its anti-viral activities. It is also essential for: maintaining proper PML nuclear bodies (PML-NBs) structure and normal function, recruitment of components of PML-NBs, the turnover and retention of PML in PML-NBs and the integrity of PML-NBs. Undergoes 'Lys-11'-linked sumoylation. Sumoylation on all three sites (Lys-70, Lys-165 and Lys-500) is required for nuclear body formation. Sumoylation on Lys-165 is a prerequisite for sumoylation on Lys-70. Lys-70 and Lys-165 are sumoylated by PISA1 and PIAS2. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 and phosphorylation at Ser- 575 which in turn triggers its ubiquitin-mediated degradation. Sumoylation at Lys-500 by RANBP2 is essential for the proper assembly of PML-NBs. Desumoylated by SENP1, SENP2, SENP3, SENP5 and SENP6 (By similarity). Phosphorylation is a major regulatory mechanism that controls PML protein abundance and the number and size of PML nuclear bodies (PML- NBs). Phosphorylated in response to DNA damage, probably by ATR. HIPK2- mediated phosphorylation at Ser-17, Ser-45 and Ser-47 leads to increased accumulation of PML protein and its sumoylation and is required for the maximal pro-apoptotic activity of PML after DNA damage. MAPK1- mediated phosphorylations at Ser-404, Ser-515 and Ser- 540 and CDK1/2-mediated phosphorylation at Ser-528 promote PIN1- dependent PML degradation. CK2-mediated phosphorylation at Ser-575 primes PML ubiquitination via an unidentified ubiquitin ligase (By similarity). Acetylation at Lys-497 is essential for its nuclear localization. Deacetylated at Lys-497 by SIRT1 and this deacetylation promotes PML control of PER2 nuclear localization (By similarity). Mice are born at the expected Mendelian rate and are fertile. They show leukopenia with reduced levels of circulating granulocytes and myeloid cells. They are highly susceptible to infections, causing a reduced life span. Mice do not exhibit normal apoptosis of hematopoietic stem cells after DNA damage due to irradiation. They do not exhibit normal apoptosis in response to FAS, TNF, TGFB1, interferons and ceramide, and show impaired activation of caspases in response to pro-apoptotic stimuli. Mice are highly susceptible to chemical carcinogens. Mice display accelerated revascularization after ischemia. Newborns have smaller brains with a reduced size of the brain cortex. Mice display aberrant learning and memory, lower levels of anxiety-like behavior and specific deficits in long-term plasticity. Mice display a compromised endogenous circadian clock with reduced precision and stability of the period length. Sequence=AAA97601.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nuclear chromosome, telomeric region response to hypoxia regulation of protein phosphorylation positive regulation of defense response to virus by host immune system process DNA binding transcription coactivator activity protein binding nucleus nucleoplasm nucleolus cytoplasm endosome endoplasmic reticulum endoplasmic reticulum membrane cytosol regulation of transcription, DNA-templated protein targeting protein import into nucleus apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest cell cycle arrest transforming growth factor beta receptor signaling pathway common-partner SMAD protein phosphorylation cell aging zinc ion binding negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress response to UV response to gamma radiation regulation of calcium ion transport into cytosol fibroblast migration membrane viral process nuclear matrix negative regulation of angiogenesis PML body myeloid cell differentiation regulation of cell adhesion negative regulation of cell growth PML body organization positive regulation of histone deacetylation ubiquitin protein ligase binding early endosome membrane nuclear membrane SUMO binding positive regulation of telomere maintenance negative regulation of telomere maintenance via telomerase endoplasmic reticulum calcium ion homeostasis circadian regulation of gene expression negative regulation of translation in response to oxidative stress response to cytokine extrinsic component of endoplasmic reticulum membrane regulation of circadian rhythm intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator protein homodimerization activity entrainment of circadian clock by photoperiod proteasome-mediated ubiquitin-dependent protein catabolic process innate immune response cell fate commitment regulation of MHC class I biosynthetic process negative regulation of transcription, DNA-templated negative regulation of mitotic cell cycle SMAD binding metal ion binding protein heterodimerization activity positive regulation of fibroblast proliferation retinoic acid receptor signaling pathway rhythmic process negative regulation of interleukin-1 secretion negative regulation of interleukin-1 beta secretion protein stabilization cobalt ion binding maintenance of protein location in nucleus defense response to virus negative regulation of telomerase activity positive regulation of apoptotic process involved in mammary gland involution branching involved in mammary gland duct morphogenesis macromolecular complex assembly intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to interleukin-4 intrinsic apoptotic signaling pathway by p53 class mediator cellular senescence extrinsic apoptotic signaling pathway negative regulation of viral release from host cell positive regulation of nucleic acid-templated transcription positive regulation of protein localization to chromosome, telomeric region cellular response to leukemia inhibitory factor negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process regulation of double-strand break repair positive regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway heterochromatin uc009pwp.1 uc009pwp.2 uc009pwp.3 uc009pwp.4 uc009pwp.5 
ENSMUST00000085677.9 Stra6 ENSMUST00000085677.9 stimulated by retinoic acid gene 6, transcript variant 3 (from RefSeq NM_001162475.1) A0A0R4J115 A0A0R4J115_MOUSE ENSMUST00000085677.1 ENSMUST00000085677.2 ENSMUST00000085677.3 ENSMUST00000085677.4 ENSMUST00000085677.5 ENSMUST00000085677.6 ENSMUST00000085677.7 ENSMUST00000085677.8 NM_001162475 Stra6 uc009pwi.1 uc009pwi.2 uc009pwi.3 uc009pwi.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein blood vessel development kidney development pulmonary valve morphogenesis ventricular septum development integral component of plasma membrane heart development learning feeding behavior membrane integral component of membrane lung development adrenal gland development female genitalia development macromolecular complex retinol transporter activity retinol transport signaling receptor activity vocal learning camera-type eye development ear development nose morphogenesis lung alveolus development positive regulation of behavior digestive tract morphogenesis embryonic digestive tract development developmental growth smooth muscle tissue development artery morphogenesis cognition neuromuscular process head development head morphogenesis face morphogenesis lung vasculature development diaphragm development embryonic camera-type eye formation eyelid development in camera-type eye uterus morphogenesis alveolar primary septum development pulmonary artery morphogenesis paramesonephric duct development ductus arteriosus closure uc009pwi.1 uc009pwi.2 uc009pwi.3 uc009pwi.4 
ENSMUST00000085678.8 Kctd3 ENSMUST00000085678.8 potassium channel tetramerisation domain containing 3, transcript variant 1 (from RefSeq NM_172650.2) ENSMUST00000085678.1 ENSMUST00000085678.2 ENSMUST00000085678.3 ENSMUST00000085678.4 ENSMUST00000085678.5 ENSMUST00000085678.6 ENSMUST00000085678.7 KCTD3_MOUSE NM_172650 Q6P7X4 Q8BFX3 uc007eai.1 uc007eai.2 uc007eai.3 Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. Interacts with HCN3. Cell membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BFX3-1; Sequence=Displayed; Name=2; IsoId=Q8BFX3-2; Sequence=VSP_020070, VSP_020071; Brain (at protein level). Expressed in the liver kidney, and heart. Belongs to the KCTD3 family. protein binding plasma membrane biological_process membrane protein homooligomerization uc007eai.1 uc007eai.2 uc007eai.3 
ENSMUST00000085679.13 Arpc1b ENSMUST00000085679.13 actin related protein 2/3 complex, subunit 1B (from RefSeq NM_023142.2) ARC1B_MOUSE ENSMUST00000085679.1 ENSMUST00000085679.10 ENSMUST00000085679.11 ENSMUST00000085679.12 ENSMUST00000085679.2 ENSMUST00000085679.3 ENSMUST00000085679.4 ENSMUST00000085679.5 ENSMUST00000085679.6 ENSMUST00000085679.7 ENSMUST00000085679.8 ENSMUST00000085679.9 NM_023142 Q9CRC4 Q9WV32 uc009amb.1 uc009amb.2 uc009amb.3 uc009amb.4 Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Cytoplasm, cytoskeleton Nucleus Belongs to the WD repeat ARPC1 family. actin binding structural constituent of cytoskeleton nucleus cytoplasm cytoskeleton Arp2/3 protein complex actin cytoskeleton regulation of actin filament polymerization response to estradiol Arp2/3 complex-mediated actin nucleation tubulobulbar complex response to estrogen macromolecular complex binding actin filament binding uc009amb.1 uc009amb.2 uc009amb.3 uc009amb.4 
ENSMUST00000085684.11 Smurf1 ENSMUST00000085684.11 SMAD specific E3 ubiquitin protein ligase 1, transcript variant 1 (from RefSeq NM_001038627.1) ENSMUST00000085684.1 ENSMUST00000085684.10 ENSMUST00000085684.2 ENSMUST00000085684.3 ENSMUST00000085684.4 ENSMUST00000085684.5 ENSMUST00000085684.6 ENSMUST00000085684.7 ENSMUST00000085684.8 ENSMUST00000085684.9 NM_001038627 Q3U412 Q8K300 Q9CUN6 SMUF1_MOUSE uc009alv.1 uc009alv.2 uc009alv.3 E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway (By similarity). Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Acts as an antagonist of TGF- beta signaling by ubiquitinating TGFBR1 and targeting it for degradation (By similarity). Plays a role in dendrite formation by melanocytes (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence=; Protein modification; protein ubiquitination. Interacts with TRAF4 (By similarity). Interacts (via HECT domain) with FBXL15 (via LRR repeats) (By similarity). Interacts with SMAD7 and TGFBR1; SMAD7 recruits SMURF1 to TGFBR1 and regulates TGF- beta receptor degradation (By similarity). Interacts with MAVS; the interaction is mediated by NDFIP1 (PubMed:23087404). Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side The C2 domain mediates membrane localization and substrate selection. Auto-ubiquitinated in presence of NDFIP1. Ubiquitinated by the SCF(FBXL15) complex at Lys-355 and Lys-357, leading to its degradation by the proteasome. Lys-357 is the primary ubiquitination site. Sequence=BAB29770.2; Type=Erroneous initiation; Evidence=; protein polyubiquitination ubiquitin-protein transferase activity protein binding cytoplasm mitochondrion cytosol plasma membrane ubiquitin-dependent protein catabolic process protein export from nucleus membrane protein ubiquitination transferase activity cell differentiation negative regulation of ossification axon BMP signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway ubiquitin-dependent SMAD protein catabolic process receptor catabolic process protein localization to cell surface neuronal cell body proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process ubiquitin protein ligase activity parkin-mediated mitophagy in response to mitochondrial depolarization engulfment of target by autophagosome substrate localization to autophagosome I-SMAD binding R-SMAD binding protein targeting to vacuole involved in autophagy positive regulation of dendrite extension positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc009alv.1 uc009alv.2 uc009alv.3 
ENSMUST00000085691.11 Dmkn ENSMUST00000085691.11 dermokine, transcript variant 2 (from RefSeq NM_172899.4) Dmkn E9QLW7 E9QLW7_MOUSE ENSMUST00000085691.1 ENSMUST00000085691.10 ENSMUST00000085691.2 ENSMUST00000085691.3 ENSMUST00000085691.4 ENSMUST00000085691.5 ENSMUST00000085691.6 ENSMUST00000085691.7 ENSMUST00000085691.8 ENSMUST00000085691.9 NM_172899 uc009ggh.1 uc009ggh.2 uc009ggh.3 uc009ggh.4 cornified envelope assembly uc009ggh.1 uc009ggh.2 uc009ggh.3 uc009ggh.4 
ENSMUST00000085701.7 Tecpr1 ENSMUST00000085701.7 tectonin beta-propeller repeat containing 1, transcript variant 1 (from RefSeq NM_027410.2) ENSMUST00000085701.1 ENSMUST00000085701.2 ENSMUST00000085701.3 ENSMUST00000085701.4 ENSMUST00000085701.5 ENSMUST00000085701.6 Kiaa1358 NM_027410 Q80VP0 Q8CHA3 Q8R3E0 Q99KQ5 Q9CVC6 TCPR1_MOUSE uc009alj.1 uc009alj.2 uc009alj.3 uc009alj.4 uc009alj.5 Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity). Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex. Cytoplasmic vesicle, autophagosome membrane Lysosome membrane Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80VP0-1; Sequence=Displayed; Name=2; IsoId=Q80VP0-2; Sequence=VSP_033862; The PH domain mediates the binding to phosphatidylinositol-3- phosphate (PtdIns(3)P). Belongs to the TECPR1 family. Sequence=AAH25567.1; Type=Erroneous initiation; Evidence=; Sequence=BAC41478.1; Type=Erroneous initiation; Evidence=; autophagosome membrane nucleoplasm lysosome lysosomal membrane autophagy lipid binding membrane integral component of membrane cytoplasmic vesicle phosphatidylinositol-3-phosphate binding intracellular membrane-bounded organelle autophagosome maturation uc009alj.1 uc009alj.2 uc009alj.3 uc009alj.4 uc009alj.5 
ENSMUST00000085708.3 Stat2 ENSMUST00000085708.3 signal transducer and activator of transcription 2 (from RefSeq NM_019963.2) ENSMUST00000085708.1 ENSMUST00000085708.2 NM_019963 Q9QXJ2 Q9QXJ2_MOUSE Stat2 uc007hma.1 uc007hma.2 Cytoplasm cleus Belongs to the transcription factor STAT family. regulation of protein phosphorylation DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm cytosol plasma membrane regulation of transcription, DNA-templated signal transduction identical protein binding ubiquitin-like protein ligase binding defense response to virus type I interferon signaling pathway regulation of mitochondrial fission uc007hma.1 uc007hma.2 
ENSMUST00000085709.6 Ppcdc ENSMUST00000085709.6 phosphopantothenoylcysteine decarboxylase, transcript variant 1 (from RefSeq NM_176831.5) COAC_MOUSE Coac ENSMUST00000085709.1 ENSMUST00000085709.2 ENSMUST00000085709.3 ENSMUST00000085709.4 ENSMUST00000085709.5 NM_176831 Q8BZB2 uc009puu.1 uc009puu.2 uc009puu.3 uc009puu.4 uc009puu.5 Catalyzes the decarboxylation of the cysteine moiety of 4- phosphopantothenoylcysteine to form 4'-phosphopantotheine and this reaction forms part of the biosynthesis of coenzyme A. Reaction=H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'- phosphopantetheine + CO2; Xref=Rhea:RHEA:16793, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:59458, ChEBI:CHEBI:61723; EC=4.1.1.36; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16794; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Note=Binds 1 FMN per subunit. ; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 3/5. Homotrimer. Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily. catalytic activity phosphopantothenoylcysteine decarboxylase activity cellular_component coenzyme A biosynthetic process lyase activity carboxy-lyase activity identical protein binding uc009puu.1 uc009puu.2 uc009puu.3 uc009puu.4 uc009puu.5 
ENSMUST00000085715.7 Mark4 ENSMUST00000085715.7 MAP/microtubule affinity regulating kinase 4, transcript variant 1 (from RefSeq NM_172279.2) ENSMUST00000085715.1 ENSMUST00000085715.2 ENSMUST00000085715.3 ENSMUST00000085715.4 ENSMUST00000085715.5 ENSMUST00000085715.6 Kiaa1860 MARK4_MOUSE Mark4 NM_172279 Q80T81 Q8CIP4 uc009fly.1 uc009fly.2 uc009fly.3 Serine/threonine-protein kinase (By similarity). Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (By similarity). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (By similarity). Required for the initiation of axoneme extension during cilium assembly (By similarity). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (By similarity). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (By similarity). Reduces neuronal cell survival (By similarity). Plays a role in energy homeostasis by regulating satiety and metabolic rate (PubMed:22992738). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (PubMed:24989893). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (By similarity). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation on Thr-214. Interacts with MAPT/TAU (By similarity). Interacts with gamma- tubulin (By similarity). Interacts with ODF2 (By similarity). Interacts with USP9X (By similarity). Interacts with YWHAQ (By similarity). Interacts with NLRP3; promoting NLRP3 recruitment to microtubule organizing center (MTOC) (PubMed:28656979). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, cilium basal body Cytoplasm Cell projection, dendrite Note=Localized at the tips of neurite- like processes in differentiated neuroblast cells. Detected in the cytoplasm and neuropil of the hippocampus. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=MARK4L; IsoId=Q8CIP4-1; Sequence=Displayed; Name=2; Synonyms=MARK4S; IsoId=Q8CIP4-2; Sequence=VSP_058199; Isoform 1 and isoform 2 show similar expression patterns in the central nervous system and are present in the same subsets of neurons including pyramidal and non-pyramidal neurons in the cerebral cortex and hippocampus, cerebellar Purkinje cells, and interneurons and motor neurons in the spinal cord but not in glial cells (at protein level) (PubMed:16973293). Isoform 2 is the major isoform in brain and cerebellum (PubMed:16973293, PubMed:15009667). Also expressed in spleen, liver, small intestine, colon, kidney, tongue, testis and lung (PubMed:16973293, PubMed:15009667). Isoform 1 and isoform 2 are expressed at similar levels in heart (PubMed:16973293). Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X (By similarity). Phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20- related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylated throughout the cell cycle. Hyperphagia, hyperactivity and hypermetabolism leading to protection from diet-induced obesity, and improved glucose homeostasis due to up-regulation of AMPK kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. nucleotide binding microtubule cytoskeleton organization gamma-tubulin complex microtubule bundle formation protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm centrosome microtubule organizing center cytoskeleton protein phosphorylation cell cycle nervous system development microtubule binding microtubule cytoskeleton kinase activity phosphorylation transferase activity cell projection organization dendrite midbody intracellular signal transduction ciliary basal body cell projection neuron projection gamma-tubulin binding cilium organization positive regulation of cilium assembly regulation of centrosome cycle tau-protein kinase activity cell division positive regulation of protein localization to centrosome uc009fly.1 uc009fly.2 uc009fly.3 
ENSMUST00000085724.5 Susd4 ENSMUST00000085724.5 sushi domain containing 4, transcript variant 1 (from RefSeq NM_144796.5) ENSMUST00000085724.1 ENSMUST00000085724.2 ENSMUST00000085724.3 ENSMUST00000085724.4 NM_144796 Q8BH32 Q8VC43 SUSD4_MOUSE uc007dyk.1 uc007dyk.2 uc007dyk.3 Acts as a complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BH32-1; Sequence=Displayed; Name=2; IsoId=Q8BH32-2; Sequence=VSP_020844; High expression in brain and eye, with weaker expression in spinal cord and testis. Detected in white matter of brain and in the outer segments of photoreceptors. In contrast some authors report that SUSD4 acts as an activator of the alternative complement pathway, while having no effect on the classical pathway (in vitro) (PubMed:20348246). These contradictory results with human may lie in the differences in protein expression, in this study SUSD4 is expressed in bacteria and not in eukaryotic cells. molecular_function cellular_component membrane integral component of membrane regulation of complement activation negative regulation of complement activation, alternative pathway negative regulation of complement activation, classical pathway uc007dyk.1 uc007dyk.2 uc007dyk.3 
ENSMUST00000085733.9 Spdye4a ENSMUST00000085733.9 speedy/RINGO cell cycle regulator family, member E4A, transcript variant 1 (from RefSeq NM_029048.3) ENSMUST00000085733.1 ENSMUST00000085733.2 ENSMUST00000085733.3 ENSMUST00000085733.4 ENSMUST00000085733.5 ENSMUST00000085733.6 ENSMUST00000085733.7 ENSMUST00000085733.8 NM_029048 Q5IBH6 SPE4A_MOUSE Spdyb Spdye4a uc009ajs.1 uc009ajs.2 Promotes progression through the cell cycle via binding and activation of CDK1. Interacts with CDK1. Does not interact with CDK2 in vivo. Nucleus Testis-specific. Belongs to the Speedy/Ringo family. cellular_component nucleus cell cycle protein kinase binding positive regulation of cyclin-dependent protein serine/threonine kinase activity uc009ajs.1 uc009ajs.2 
ENSMUST00000085741.2 Ttc32 ENSMUST00000085741.2 tetratricopeptide repeat domain 32 (from RefSeq NM_029321.2) ENSMUST00000085741.1 NM_029321 Q9DAC7 TTC32_MOUSE uc007nal.1 uc007nal.2 molecular_function cellular_component biological_process uc007nal.1 uc007nal.2 
ENSMUST00000085774.11 Sdk1 ENSMUST00000085774.11 sidekick cell adhesion molecule 1 (from RefSeq NM_177879.5) ENSMUST00000085774.1 ENSMUST00000085774.10 ENSMUST00000085774.2 ENSMUST00000085774.3 ENSMUST00000085774.4 ENSMUST00000085774.5 ENSMUST00000085774.6 ENSMUST00000085774.7 ENSMUST00000085774.8 ENSMUST00000085774.9 NM_177879 Q3UFD1 Q3UH53 Q6PAL2 Q6V3A4 Q8BMC2 Q8BZI1 SDK1_MOUSE Sdk1 uc009ail.1 uc009ail.2 uc009ail.3 uc009ail.4 Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. Homodimer; mediates homophilic interactions to promote cell adhesion (PubMed:15703275). Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4 (PubMed:20219992). [Isoform 2]: Does not mediate homophilic interactions (PubMed:15703275). Cell membrane ; Single-pass type I membrane protein Synapse Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UH53-1; Sequence=Displayed; Name=2; IsoId=Q3UH53-2; Sequence=VSP_017520, VSP_017521; Expressed by non-overlapping subsets of retinal neurons. Sdk1 and Sdk2 are expressed in non-overlapping subsets of interneurons and retinal ganglion cells (RGCs) that form synapses in distinct inner plexiform layer (IPL) sublaminae (at protein level). Highly expressed in many fetal tissues, inlcuding kidney but shows markedly lower expression in adult organs. Expression in kidney is high throughout development with maximal expression occurring near birth. the PDZ-binding motif mediates interaction with PDZ domain- containing proteins MAGI1, MAGI2, DLG2, DLG3 and DLG4 and is required for is required for synaptic localization in photoreceptors. Ig-like C2-type domains 1 and 2 mediate homophilic interactions. Belongs to the sidekick family. Sequence=BAC28069.1; Type=Erroneous initiation; Evidence=; Sequence=BAC28986.1; Type=Erroneous initiation; Evidence=; molecular_function plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly retina layer formation membrane integral component of membrane cell junction identical protein binding synapse behavioral response to cocaine regulation of dendritic spine development uc009ail.1 uc009ail.2 uc009ail.3 uc009ail.4 
ENSMUST00000085786.7 Card11 ENSMUST00000085786.7 caspase recruitment domain family, member 11, transcript variant 1 (from RefSeq NM_175362.3) CAR11_MOUSE Card11 Carma1 ENSMUST00000085786.1 ENSMUST00000085786.2 ENSMUST00000085786.3 ENSMUST00000085786.4 ENSMUST00000085786.5 ENSMUST00000085786.6 NM_175362 Q4VA14 Q6KAS3 Q8BYV0 Q8CIS0 uc009aik.1 uc009aik.2 uc009aik.3 uc009aik.4 Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T- cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:12356734, PubMed:12154356, PubMed:16356855). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:12356734, PubMed:12154356, PubMed:16356855). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (By similarity). Its binding to DPP4 induces T- cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner (By similarity). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (By similarity). Stimulates the phosphorylation of BCL10 (By similarity). Also activates the TORC1 signaling pathway (By similarity). Maintained in an autoinhibited state via homodimerization in which the CARD domain forms an extensive interaction with the adjacent linker and coiled-coil regions (By similarity). Activation downstream of T-cell receptor (TCR) by phosphorylation by PRKCB and PRKCQ triggers CARD11 homooligomerization and BCL10 recruitment, followed by activation of NF-kappa-B (PubMed:16356855). Homodimer; disulfide-linked (By similarity). Homomultimer; polymerizes following activation, forming a nucleating helical template that seeds BCL10-filament formation via a CARD-CARD interaction (By similarity). Interacts (via CARD domain) with BCL10 (via CARD domain); interaction takes place following CARD11 activation and polymerization, leading to the formation of a filamentous CBM complex assembly (PubMed:22880103). Component of a CBM complex (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation (By similarity). Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (By similarity). Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail) (By similarity). Cytoplasm Membrane raft Note=Colocalized with DPP4 in membrane rafts. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CIS0-1; Sequence=Displayed; Name=2; IsoId=Q8CIS0-2; Sequence=VSP_031595; The linker region, also named autoinhibitory interface, is less inhibitory on its own than that of CARD9. The linker region together with the inhibitory domain (ID) are required to prevent constitutive activation and maintain CARD11 in an autoinhibitory state. Disruption of the inhibitory domain (ID) region triggers polymerization and activation, leading to formation of BCL10-nucleating filaments. Phosphorylation at Ser-564, Ser-649 and Ser-657 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling. Impaired activation of NF-kappa-B downstream of T-cell receptor (TCR), leading to defects in interleukin-2 (IL2) production. Sequence=BAD21384.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; immunological synapse positive regulation of cytokine production immunoglobulin production protein binding cytoplasm plasma membrane signal transduction I-kappaB kinase/NF-kappaB signaling membrane B cell differentiation positive regulation of B cell proliferation T cell costimulation CBM complex TORC1 signaling B cell proliferation positive regulation of T cell proliferation T cell activation regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling thymic T cell selection positive regulation of interleukin-2 biosynthetic process membrane raft regulation of B cell differentiation regulation of T cell differentiation lymphocyte activation homeostasis of number of cells CARD domain binding regulation of immune response positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity interleukin-2 secretion uc009aik.1 uc009aik.2 uc009aik.3 uc009aik.4 
ENSMUST00000085792.5 Zfp940 ENSMUST00000085792.5 zinc finger protein 940, transcript variant 1 (from RefSeq NM_173738.3) BC027344 ENSMUST00000085792.1 ENSMUST00000085792.2 ENSMUST00000085792.3 ENSMUST00000085792.4 NM_173738 Q8R2Q3 Q8R2Q3_MOUSE Zfp940 uc009gcg.1 uc009gcg.2 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009gcg.1 uc009gcg.2 
ENSMUST00000085797.6 Lefty2 ENSMUST00000085797.6 left-right determination factor 2 (from RefSeq NM_177099.4) ENSMUST00000085797.1 ENSMUST00000085797.2 ENSMUST00000085797.3 ENSMUST00000085797.4 ENSMUST00000085797.5 LFTY2_MOUSE Leftb NM_177099 P57785 Q8BMF7 uc007dwu.1 uc007dwu.2 uc007dwu.3 uc007dwu.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This protein is also important in self-renewal and differentiation of mouse embryonic stem cells. Mice lacking a functional copy of this gene exhibit defects in axial and left-right patterning. [provided by RefSeq, Aug 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066224.1, CV736182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Required for left-right asymmetry determination of organ systems in mammals. Secreted. At the primitive streak stage (7.0 dpc), expressed in the emerging mesoderm. By 8.0 dpc, expressed exclusively on the left side of developing embryos with expression predominantly in the lateral-plate mesoderm (LPM). Weak expression in the prospective floor plate (PFP). The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner. Belongs to the TGF-beta family. cytokine activity transforming growth factor beta receptor binding extracellular region extracellular space multicellular organism development growth factor activity positive regulation of pathway-restricted SMAD protein phosphorylation BMP signaling pathway regulation of apoptotic process regulation of MAPK cascade cell development SMAD protein signal transduction uc007dwu.1 uc007dwu.2 uc007dwu.3 uc007dwu.4 
ENSMUST00000085814.5 Ncoa1 ENSMUST00000085814.5 nuclear receptor coactivator 1, transcript variant 1 (from RefSeq NM_010881.3) ENSMUST00000085814.1 ENSMUST00000085814.2 ENSMUST00000085814.3 ENSMUST00000085814.4 NCOA1_MOUSE NM_010881 P70365 P70366 Q61202 Q66JL7 Q8CBI9 Src1 uc007mxs.1 uc007mxs.2 uc007mxs.3 Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Interacts with PPARA; the interaction is direct (By similarity). Interacts with PPARG; the interaction is direct (By similarity). Interacts with ESRRG; the interaction is direct (By similarity). Interacts with STAT5A (via FDL motif) (By similarity). Interacts with STAT5B (via FDL motif) (By similarity). Interacts with STAT6 (via LXXLL motif) (PubMed:14757047). Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif) (PubMed:16148126). Interacts with ASXL1 (By similarity). Interacts with the methyltransferase CARM1 (PubMed:10381882). Interacts with COPS5 (By similarity). Interacts with the histone acetyltransferase CREBBP (PubMed:8616895). Interacts with DDX5 (By similarity). Interacts with the histone acetyltransferase EP300 (PubMed:8616895, PubMed:8855229). Interacts with ESR1 (By similarity). Interacts with GCCR (By similarity). Interacts with the basal transcription factor GTF2B (By similarity). Interacts with NCOA6 (By similarity). Interacts with NCOA2 (By similarity). Interacts with NR3C1 (By similarity). Interacts with NR4A1/Nur77 (By similarity). Interacts with NR4A3 (PubMed:12709428). Interacts with PCAF (By similarity). Interacts with PGR (By similarity). Interacts with PRMT2 (By similarity). Interacts with PRMT6 (By similarity). Interacts with PSMB9 (By similarity). Interacts with RXRA, the interaction is ligand- dependent (By similarity). Interacts with STAT3 following IL-6 stimulation (By similarity). Interacts with TRA (By similarity). Interacts with TRIP4 (By similarity). Interacts with TTLL5/STAMP (By similarity). Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity (By similarity). Interacts with VDR (By similarity). Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=SRC-1A, SRC1a; IsoId=P70365-1; Sequence=Displayed; Name=2; Synonyms=SRC-1E, SRC1e; IsoId=P70365-2; Sequence=VSP_011740; Name=3; IsoId=P70365-3; Sequence=VSP_011741; Name=4; IsoId=P70365-4; Sequence=VSP_027855, VSP_027856; Widely expressed. The C-terminal (1113-1447) part mediates the histone acetyltransferase (HAT) activity. Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro. Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein (By similarity). Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites (By similarity). Mice show partial hormone resistance: target organs such as uterus, prostate, testis and mammary gland exhibiting decreased growth and development in response to steroid hormones. Moreover, such mice are prone to obesity due to reduced energy expenditure. Belongs to the SRC/p160 nuclear receptor coactivator family. positive regulation of transcription from RNA polymerase II promoter by galactose nuclear chromatin RNA polymerase II regulatory region DNA binding regulation of thyroid hormone mediated signaling pathway DNA binding chromatin binding transcription coactivator activity histone acetyltransferase activity protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane transcription, DNA-templated regulation of transcription, DNA-templated lactation transcription factor binding male gonad development response to hormone transferase activity transferase activity, transferring acyl groups ligand-dependent nuclear receptor binding aryl hydrocarbon receptor binding enzyme binding cerebellum development hippocampus development hypothalamus development cerebral cortex development estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity response to estradiol response to retinoic acid response to progesterone cellular response to hormone stimulus macromolecular complex progesterone receptor binding nuclear hormone receptor binding retinoic acid receptor binding neuron projection positive regulation of apoptotic process histone H4 acetylation estrous cycle macromolecular complex binding positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription from RNA polymerase II promoter retinoid X receptor binding protein dimerization activity protein N-terminus binding male mating behavior labyrinthine layer morphogenesis cellular response to Thyroglobulin triiodothyronine regulation of cellular response to drug regulation of RNA biosynthetic process uc007mxs.1 uc007mxs.2 uc007mxs.3 
ENSMUST00000085818.6 Kcnk6 ENSMUST00000085818.6 potassium inwardly-rectifying channel, subfamily K, member 6 (from RefSeq NM_001033525.3) ENSMUST00000085818.1 ENSMUST00000085818.2 ENSMUST00000085818.3 ENSMUST00000085818.4 ENSMUST00000085818.5 Kcnk6 NM_001033525 Q3TBV4 Q3TBV4_MOUSE uc009gbg.1 uc009gbg.2 uc009gbg.3 uc009gbg.4 Membrane ulti-pass membrane protein Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. regulation of systemic arterial blood pressure negative regulation of systemic arterial blood pressure potassium channel activity integral component of plasma membrane ion transport potassium ion transport membrane integral component of membrane potassium ion leak channel activity stabilization of membrane potential regulation of resting membrane potential potassium ion transmembrane transport uc009gbg.1 uc009gbg.2 uc009gbg.3 uc009gbg.4 
ENSMUST00000085835.8 Map4k1 ENSMUST00000085835.8 mitogen-activated protein kinase kinase kinase kinase 1, transcript variant 1 (from RefSeq NM_008279.3) ENSMUST00000085835.1 ENSMUST00000085835.2 ENSMUST00000085835.3 ENSMUST00000085835.4 ENSMUST00000085835.5 ENSMUST00000085835.6 ENSMUST00000085835.7 Hpk1 M4K1_MOUSE NM_008279 P70218 Q8R3R0 Q99K62 uc009gam.1 uc009gam.2 uc009gam.3 uc009gam.4 Serine/threonine-protein kinase, which may play a role in the response to environmental stress (By similarity). Appears to act upstream of the JUN N-terminal pathway (PubMed:9003777). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:9003777). Able to autophosphorylate (PubMed:9003777). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (PubMed:11509653). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with MAP3K1 (By similarity). Interacts with FBXW8 (By similarity). Interacts with CLNK (via its SH2 domain) (PubMed:11509653). P70218; Q9BXL7: CARD11; Xeno; NbExp=2; IntAct=EBI-2906801, EBI-7006141; P70218; Q16584: MAP3K11; Xeno; NbExp=3; IntAct=EBI-2906801, EBI-49961; Expressed in hemopoietic cells (at protein level) (PubMed:11509653). Ubiquitously expressed in all tissues examined at embryonic stage 16.5 dpc with high levels in lung, heart and fetal liver. In the neonate, expression is restricted to the tissues which undergo lineage decisions, lung, thymus, liver, kidney and brain. In the adult, expression is limited to hemopoietic organs, thymus, bone marrow, and spleen and to the testis (PubMed:9003777). Autophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome. Tyrosine-phosphorylated after activation of hemopoietic cells. Ubiquitinated by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex following autophosphorylation, leading to its degradation by the proteasome. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Sequence=AAH05433.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; nucleotide binding activation of MAPKKK activity protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm protein phosphorylation activation of JUN kinase activity cell proliferation MAP kinase kinase kinase kinase activity kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation signal transduction by protein phosphorylation activation of protein kinase activity intracellular signal transduction protein autophosphorylation cellular response to phorbol 13-acetate 12-myristate uc009gam.1 uc009gam.2 uc009gam.3 uc009gam.4 
ENSMUST00000085840.11 Ttbk2 ENSMUST00000085840.11 tau tubulin kinase 2, transcript variant 2 (from RefSeq NM_001024856.3) A2AW12 Bby ENSMUST00000085840.1 ENSMUST00000085840.10 ENSMUST00000085840.2 ENSMUST00000085840.3 ENSMUST00000085840.4 ENSMUST00000085840.5 ENSMUST00000085840.6 ENSMUST00000085840.7 ENSMUST00000085840.8 ENSMUST00000085840.9 Kiaa0847 NM_001024856 Q3TSR6 Q3UFW0 Q3UVR3 Q571D1 Q8BKA4 Q924U8 TTBK2_MOUSE Ttbk1 uc008lww.1 uc008lww.2 uc008lww.3 uc008lww.4 Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts with CEP164. Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytosol Nucleus Note=Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis. May also be present in cytosol and, at lower level in the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UVR3-1; Sequence=Displayed; Name=2; IsoId=Q3UVR3-2; Sequence=VSP_018276; Defects in Ttbk2 are the cause of the bartleby (bby) phenotype characterized by defects in sonic hedgehog/SHH signaling and ciliogenesis. Embryos display morphological defects at midgestation similar to those seen in mutants that lack cilia, including holoprosencephaly, twisted body axis, abnormal limb development and randomized laterality of heart looping. Mutants die at midgestation (around 10.5 dpc). Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Sequence=BAD90183.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding microtubule cytoskeleton organization protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm centriole cytosol cytoskeleton cilium protein phosphorylation negative regulation of microtubule depolymerization smoothened signaling pathway regulation of smoothened signaling pathway kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation kinesin binding cerebellum development cerebellar granular layer development neural tube development cerebellar granule cell precursor tangential migration cell projection organization regulation of cell migration forebrain development ciliary transition zone ciliary basal body embryonic digit morphogenesis cell projection cilium assembly negative regulation of protein localization to microtubule positive regulation of non-motile cilium assembly negative regulation of cellular protein localization negative regulation of microtubule binding embryonic brain development uc008lww.1 uc008lww.2 uc008lww.3 uc008lww.4 
ENSMUST00000085856.12 Zfp157 ENSMUST00000085856.12 zinc finger protein 157 (from RefSeq NM_028130.3) ENSMUST00000085856.1 ENSMUST00000085856.10 ENSMUST00000085856.11 ENSMUST00000085856.2 ENSMUST00000085856.3 ENSMUST00000085856.4 ENSMUST00000085856.5 ENSMUST00000085856.6 ENSMUST00000085856.7 ENSMUST00000085856.8 ENSMUST00000085856.9 NM_028130 Q6PCM4 Q6PCM4_MOUSE Zfp157 uc009afo.1 uc009afo.2 uc009afo.3 uc009afo.4 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of cell fate commitment sequence-specific DNA binding metal ion binding lung alveolus development mammary gland morphogenesis uc009afo.1 uc009afo.2 uc009afo.3 uc009afo.4 
ENSMUST00000085876.12 Ifi208 ENSMUST00000085876.12 interferon activated gene 208, transcript variant 1 (from RefSeq NM_001162938.2) ENSMUST00000085876.1 ENSMUST00000085876.10 ENSMUST00000085876.11 ENSMUST00000085876.2 ENSMUST00000085876.3 ENSMUST00000085876.4 ENSMUST00000085876.5 ENSMUST00000085876.6 ENSMUST00000085876.7 ENSMUST00000085876.8 ENSMUST00000085876.9 IFI8_MOUSE Ifi208 NM_001162938 Pydc3 Q3V3Q4 Q8BLW5 uc007drt.1 uc007drt.2 uc007drt.3 Belongs to the HIN-200 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding activation of innate immune response double-stranded DNA binding nucleus nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding uc007drt.1 uc007drt.2 uc007drt.3 
ENSMUST00000085894.12 Cfap45 ENSMUST00000085894.12 cilia and flagella associated protein 45 (from RefSeq NM_027972.1) CFA45_MOUSE Ccdc19 ENSMUST00000085894.1 ENSMUST00000085894.10 ENSMUST00000085894.11 ENSMUST00000085894.2 ENSMUST00000085894.3 ENSMUST00000085894.4 ENSMUST00000085894.5 ENSMUST00000085894.6 ENSMUST00000085894.7 ENSMUST00000085894.8 ENSMUST00000085894.9 NM_027972 Nesg1 Q9D9U9 uc007dqq.1 uc007dqq.2 uc007dqq.3 uc007dqq.4 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). It is an AMP-binding protein that may facilitate dynein ATPase-dependent ciliary and flagellar beating via adenine nucleotide homeostasis. May function as a donor of AMP to AK8 and hence promote ADP production (PubMed:33139725). Interacts with AK8; dimerization with AK8 may create a cavity at the interface of the dimer that can accommodate AMP (By similarity). Interacts with CFAP52 (By similarity). Interacts with ENKUR (By similarity). Directly interacts with DNALI1 (By similarity). Interacts with DNAH11 (By similarity). Interacts with DNAI1 (By similarity). Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme Note=Located in the proximal region of respiratory cilia. Expressed in respiratory cells and in sperm (at protein level). Knockout animals display left-right asymmetry abnormalities, including situs inversus totalis. Nodal cilia rotational speed is reduced compared to heterozyous littermates. Mutant males also exhibit asthenospermia and are infertile. Belongs to the CFAP45 family. molecular_function nucleoplasm biological_process uc007dqq.1 uc007dqq.2 uc007dqq.3 uc007dqq.4 
ENSMUST00000085901.13 Dyrk1b ENSMUST00000085901.13 dual-specificity tyrosine phosphorylation regulated kinase 1b, transcript variant 1 (from RefSeq NM_001037957.4) DYR1B_MOUSE ENSMUST00000085901.1 ENSMUST00000085901.10 ENSMUST00000085901.11 ENSMUST00000085901.12 ENSMUST00000085901.2 ENSMUST00000085901.3 ENSMUST00000085901.4 ENSMUST00000085901.5 ENSMUST00000085901.6 ENSMUST00000085901.7 ENSMUST00000085901.8 ENSMUST00000085901.9 NM_001037957 Q3UFR5 Q70UR5 Q9EPM2 Q9Z188 uc009fya.1 uc009fya.2 uc009fya.3 uc009fya.4 Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:12633499). Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance. During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Inhibited by RANBP9. Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with DCAF7. Interacts with RNF169. Nucleus Nucleus, nucleolus Chromosome Note=Localizes to sites of double- strand breaks (DSBs) following DNA damage. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=p69; IsoId=Q9Z188-1; Sequence=Displayed; Name=2; Synonyms=p65; IsoId=Q9Z188-2; Sequence=VSP_022955; Name=3; Synonyms=p75; IsoId=Q9Z188-3; Sequence=VSP_022954; Isoform 1 and isoform 2 are broadly expressed. Isoform 3 seems specific for skeletal muscle (at protein level). Isoform 1 is present from 14 dpc. Isoform 3 is present from 18 dpc (at protein level). Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization (By similarity). [Isoform 2]: Inactive. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. nucleotide binding transcription coactivator activity protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity ATP binding nucleus protein phosphorylation myoblast fusion kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation positive regulation of transcription, DNA-templated protein autophosphorylation adipose tissue development uc009fya.1 uc009fya.2 uc009fya.3 uc009fya.4 
ENSMUST00000085912.10 Igsf8 ENSMUST00000085912.10 Igsf8 (from geneSymbol) A0A0R4J117 A0A0R4J117_MOUSE AF439263 ENSMUST00000085912.1 ENSMUST00000085912.2 ENSMUST00000085912.3 ENSMUST00000085912.4 ENSMUST00000085912.5 ENSMUST00000085912.6 ENSMUST00000085912.7 ENSMUST00000085912.8 ENSMUST00000085912.9 Igsf8 uc287nxy.1 uc287nxy.2 membrane integral component of membrane uc287nxy.1 uc287nxy.2 
ENSMUST00000085913.11 Atp1a2 ENSMUST00000085913.11 ATPase, Na+/K+ transporting, alpha 2 polypeptide (from RefSeq NM_178405.3) AT1A2_MOUSE ENSMUST00000085913.1 ENSMUST00000085913.10 ENSMUST00000085913.2 ENSMUST00000085913.3 ENSMUST00000085913.4 ENSMUST00000085913.5 ENSMUST00000085913.6 ENSMUST00000085913.7 ENSMUST00000085913.8 ENSMUST00000085913.9 NM_178405 Q6PIE5 Q80UZ8 uc007dqc.1 uc007dqc.2 This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). Reaction=ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate; Xref=Rhea:RHEA:18353, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.13; The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1. Q6PIE5; P11881: Itpr1; NbExp=3; IntAct=EBI-6665421, EBI-541478; Q6PIE5; O35157: Slc8a1; NbExp=4; IntAct=EBI-6665421, EBI-8351080; Membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. nucleotide binding neurotransmitter uptake regulation of the force of heart contraction regulation of respiratory gaseous exchange by neurological system process sodium:potassium-exchanging ATPase activity protein binding ATP binding cytoplasm endosome plasma membrane sodium:potassium-exchanging ATPase complex caveola ion transport potassium ion transport sodium ion transport cellular sodium ion homeostasis regulation of muscle contraction regulation of smooth muscle contraction regulation of striated muscle contraction drug binding regulation of blood pressure adult locomotory behavior visual learning potassium-transporting ATPase activity establishment or maintenance of transmembrane electrochemical gradient intercalated disc membrane integral component of membrane ATPase activity regulation of vasoconstriction cation-transporting ATPase activity cellular potassium ion homeostasis T-tubule potassium ion binding sodium ion binding response to nicotine sodium ion export from cell locomotion sarcolemma neuron projection dendritic spine myelin sheath synapse negative regulation of heart contraction negative regulation of striated muscle contraction ATP metabolic process metal ion binding chaperone binding negative regulation of cytosolic calcium ion concentration cellular response to mechanical stimulus cellular response to steroid hormone stimulus regulation of cardiac muscle cell contraction hydrogen ion transmembrane transport negative regulation of calcium ion transmembrane transport negative regulation of calcium:sodium antiporter activity response to glycoside steroid hormone binding potassium ion import across plasma membrane uc007dqc.1 uc007dqc.2 
ENSMUST00000085939.8 Fxyd6 ENSMUST00000085939.8 FXYD domain-containing ion transport regulator 6 (from RefSeq NM_022004.6) ENSMUST00000085939.1 ENSMUST00000085939.2 ENSMUST00000085939.3 ENSMUST00000085939.4 ENSMUST00000085939.5 ENSMUST00000085939.6 ENSMUST00000085939.7 FXYD6_MOUSE NM_022004 Plp Q99NC3 Q9CXD0 Q9D164 uc009pfs.1 uc009pfs.2 uc009pfs.3 This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, Fxyd6, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Jul 2006]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC042579.1, SRR1660815.277566.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D164-1; Sequence=Displayed; Name=2; IsoId=Q9D164-2; Sequence=VSP_001585; Belongs to the FXYD family. plasma membrane ion transport membrane integral component of membrane sodium channel regulator activity regulation of ion transport glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane ion channel regulator activity regulation of sodium ion transmembrane transporter activity uc009pfs.1 uc009pfs.2 uc009pfs.3 
ENSMUST00000085941.12 Znhit1 ENSMUST00000085941.12 zinc finger, HIT domain containing 1, transcript variant 2 (from RefSeq NM_001310747.1) ENSMUST00000085941.1 ENSMUST00000085941.10 ENSMUST00000085941.11 ENSMUST00000085941.2 ENSMUST00000085941.3 ENSMUST00000085941.4 ENSMUST00000085941.5 ENSMUST00000085941.6 ENSMUST00000085941.7 ENSMUST00000085941.8 ENSMUST00000085941.9 NM_001310747 Q8R331 Q9CZS6 ZNHI1_MOUSE uc009abh.1 uc009abh.2 uc009abh.3 uc009abh.4 Plays a role in chromatin remodeling by promoting the incorporation of histone variant H2AZ1/H2A.Z into the genome to regulate gene expression (PubMed:29138493, PubMed:30842416, PubMed:32694618, PubMed:33913477, PubMed:35413238, PubMed:35167494). Promotes SRCAP complex-mediated deposition of histone variant H2AZ1 to lymphoid fate regulator genes, enhancing lymphoid lineage commitment (PubMed:29138493). Recruited to the promoter of the transcriptional activator MYOG at the early stages of muscle differentiation where it mediates binding of histone variant H2AZ1 to chromatin and induces muscle-specific gene expression (By similarity). Maintains hematopoietic stem cell (HSC) quiescence by determining the chromatin accessibility at distal enhancers of HSC quiescence genes such as PTEN, FSTL1 and KLF4, enhancing deposition of H2AZ1 to promote their sustained transcription and restricting PI3K-AKT signaling inhibition (PubMed:32694618). Plays a role in intestinal stem cell maintenance by promoting H2AZ1 deposition at the transcription start sites of genes involved in intestinal stem cell fate determination including LGR5, TGFB1 and TGFBR2, thereby contributing to gene transcription (PubMed:30842416). Promotes phosphorylation of the H2AZ1 chaperone VPS72/YL1 which enhances the interaction between HZAZ1 and VPS72 (PubMed:30842416). Regulates the entry of male germ cells into meiosis by controlling histone H2AZ1 deposition which facilitates the expression of meiotic genes such as MEIOSIN, leading to the initiation of meiosis (PubMed:35413238). Required for postnatal heart function through its role in maintenance of cardiac Ca(2+) homeostasis by modulating the expression of Ca(2+)-regulating proteins CASQ1 and ATP2A2/SERCA2A via deposition of histone H2AZ1 at their promoters (PubMed:35167494). During embryonic heart development, required for mitochondrial maturation and oxidative metabolism by functioning through H2AZ1 deposition to activate transcription of metabolic genes and is also required to maintain the stability of the respiratory complex (PubMed:33913477). In neural cells, increases deposition of the H2AZ1 histone variant and promotes neurite growth (By similarity). Plays a role in TP53/p53-mediated apoptosis induction by stimulating the transcriptional activation of several proapoptotic p53 target genes such as PMAIP1/NOXA and BBC3/PUMA (By similarity). Mediates cell cycle arrest induced in response to gamma-irradiation by enhancing recruitment of TP53/p53 to the promoter of the cell cycle inhibitor CDKN1A, leading to its transcriptional activation (By similarity). Recruited to the promoter of cyclin-dependent kinase CDK6 and inhibits its transcription, possibly by decreasing the acetylation level of histone H4, leading to cell cycle arrest at the G1 phase (PubMed:19501046). Plays a role in lens fiber cell differentiation by regulating the expression of cell cycle regulator CDKN1A/p21Cip1 (PubMed:35472217). Binds to transcriptional repressor NR1D2 and relieves it of its inhibitory effect on the transcription of apolipoprotein APOC3 without affecting its DNA-binding activity (By similarity). Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1 (By similarity). Interacts with MAPK11 and MAPK14 (By similarity). Interacts with NR1D1 and NR2D2 (By similarity). Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP (By similarity). Interacts with histone deacetylase HDAC1 (PubMed:19501046). Interacts with histone H2AZ1; the interaction results in recruitment of H2AZ1 to the MYOG promoter region (By similarity). Interacts with PCID2; the interaction results in inhibition of SRCAP complex activity, preventing the deposition of histone variant H2AZ1 to lymphoid fate regulator genes and restricting lymphoid lineage commitment (PubMed:29138493). Nucleus Higher expression in testis than in other tissues (at protein level) (PubMed:35413238). Expressed in the lens (at protein level) (PubMed:35472217). In the intestinal epithelium, expression is enriched at the bottom of crypts (PubMed:30842416). In hematopoietic cells, enriched in hematopoietic stem cells and progenitors with significantly reduced expression in differentiated cells such as granulocytes, monocytes, T cells and B cells (PubMed:32694618). Expression increases during muscle differentiation (at protein level) (PubMed:20473270). In the lens, expressed at high levels throughout embryonic and early postnatal stages and then gradually diminishes to adulthood (at protein level) (PubMed:35472217). In the developing embryonic heart, expression is significantly increased at 11.5 dpc and 12.5 dpc (PubMed:33913477). Phosphorylated on Thr by MAPK11 or MAPK14 (PubMed:20473270). Phosphorylation is required for MYOG induction, for deposition of histone H2AZ1 at the MYOG promoter and for SRCAP complex integrity (By similarity). Conditional knockout in hematopoietic stem cells abrogates deposition of histone variant H2az1/H2A.Z to lymphoid fate regulator genes and causes reduced bone marrow cellularity and a decreased number of common lymphoid progenitors but an increased number of common myeloid progenitors compared with wild-type mice (PubMed:29138493). Conditional knockout in intestinal epithelium results in intestinal epithelium dysfunction after birth with dramatic body weight decrease leading to the death of 30% of mice after the first postnatal week while survivors show obvious growth retardation at P30 (PubMed:30842416). Intestinal villi and inter-villi structures are normal at 18.5 dpc but enlarged crypts and defective villi are observed during the postnatal crypt morphogenesis stage with depletion of Lgr5+ intestinal stem cells (PubMed:30842416). Conditional knockout in hematopoietic stem cells (HSCs) results in dramatic HSC expansion (PubMed:32694618). Conditional knockout in male germ cells blocks meiotic initiation, resulting in defective spermatogenesis and male infertility (PubMed:35413238). Conditional knockout in postnatal cardiomyocytes results in arrhythmia, idiopathic vacuolar cardiomyopathy, rapid heart failure and premature sudden death with massively elevated levels of Casq1 and reduced levels of Atp2a2/Serca2 (PubMed:35167494). Conditional knockout in embryonic cardiomyocytes results in reduced protein levels of Vps72/Yl1 and histone H2az1 with impairment of heart development by 13.5 dpc and heart failure by 18.5 dpc (PubMed:33913477). Mutants start to die from 17.5 dpc with half dying before birth and the remainder surviving after birth for less than half a day (PubMed:33913477). Mutants show myocardial mitochondrial swelling, severe damage to the cristae and impaired integrity of the respiratory complex (PubMed:33913477). Conditional knockout in the lens results in severe cataracts, microphthalmia, lens fibrosis, abnormal lens fiber cell differentiation with decreased cell proliferation and increased cell apoptosis of the lens epithelia, increased chromatin accessibility of the Cdkn1a/p21Cip1 and Cdkn1c/p57Kip2 promoters and increased Cdkn1a and Cdkn1c levels (PubMed:35472217). Belongs to the ZNHIT1 family. negative regulation of transcription from RNA polymerase II promoter Swr1 complex chromatin binding nucleus nucleoplasm chromatin remodeling regulation of histone deacetylation nucleosome binding regulation of T cell proliferation histone deacetylase binding histone exchange metal ion binding negative regulation of G0 to G1 transition uc009abh.1 uc009abh.2 uc009abh.3 uc009abh.4 
ENSMUST00000085944.6 Nlrp9c ENSMUST00000085944.6 NLR family, pyrin domain containing 9C (from RefSeq NM_001042612.2) ENSMUST00000085944.1 ENSMUST00000085944.2 ENSMUST00000085944.3 ENSMUST00000085944.4 ENSMUST00000085944.5 NLR9C_MOUSE NM_001042612 Nalp9c Q3ULL8 Q66X01 Q6UTW8 uc009fuj.1 uc009fuj.2 uc009fuj.3 May be involved in inflammation. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q66X01-1; Sequence=Displayed; Name=2; IsoId=Q66X01-2; Sequence=VSP_025027, VSP_025028, VSP_025029; Oocyte specific. Belongs to the NLRP family. nucleotide binding immune system process molecular_function ATP binding cellular_component cytoplasm inflammatory response biological_process innate immune response uc009fuj.1 uc009fuj.2 uc009fuj.3 
ENSMUST00000085984.11 Bud23 ENSMUST00000085984.11 BUD23, rRNA methyltransferase and ribosome maturation factor, transcript variant 1 (from RefSeq NM_025375.4) BUD23_MOUSE Bud23 ENSMUST00000085984.1 ENSMUST00000085984.10 ENSMUST00000085984.2 ENSMUST00000085984.3 ENSMUST00000085984.4 ENSMUST00000085984.5 ENSMUST00000085984.6 ENSMUST00000085984.7 ENSMUST00000085984.8 ENSMUST00000085984.9 NM_025375 Q3U915 Q9CY21 Wbscr22 uc008zxn.1 uc008zxn.2 S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA- modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro. Reaction=a guanosine in 18S rRNA + S-adenosyl-L-methionine = an N(7)- methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54584, Rhea:RHEA-COMP:13937, Rhea:RHEA-COMP:13938, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74480; Evidence=; Heterodimer with TRMT112; this heterodimerization is necessary for the metabolic stability and activity of the catalytic subunit BUD23. Interacts with GRIP1. Nucleus Nucleus, nucleoplasm Cytoplasm, perinuclear region Cytoplasm Note=Localized diffusely throughout the nucleus and the cytoplasm. Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes. Localization is not affected by glucocorticoid treatment. May be ubiquitinated and targeted to degradation in response to pro-inflammatory cytokine signaling. Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family. nucleus nucleoplasm nucleolus cytoplasm chromatin organization rRNA processing methyltransferase activity rRNA (guanine) methyltransferase activity transferase activity methylation ribosome biogenesis protein heterodimerization activity perinuclear region of cytoplasm rRNA (guanine-N7)-methylation positive regulation of rRNA processing uc008zxn.1 uc008zxn.2 
ENSMUST00000085989.8 Cldn9 ENSMUST00000085989.8 claudin 9 (from RefSeq NM_020293.3) CLD9_MOUSE ENSMUST00000085989.1 ENSMUST00000085989.2 ENSMUST00000085989.3 ENSMUST00000085989.4 ENSMUST00000085989.5 ENSMUST00000085989.6 ENSMUST00000085989.7 NM_020293 Q6PEA4 Q9Z0S7 uc008asx.1 uc008asx.2 uc008asx.3 This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is developmentally regulated; it is expressed in neonate kidney, but disappers by adulthood. It is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness. [provided by RefSeq, Aug 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC058186.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Interacts with CLDN1, CD81 and OCLN. Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein Belongs to the claudin family. virus receptor activity structural molecule activity plasma membrane bicellular tight junction membrane integral component of membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding intracellular membrane-bounded organelle cell-cell junction organization viral entry into host cell uc008asx.1 uc008asx.2 uc008asx.3 
ENSMUST00000086006.12 Zfp111 ENSMUST00000086006.12 zinc finger protein 111, transcript variant 1 (from RefSeq NM_019940.2) ENSMUST00000086006.1 ENSMUST00000086006.10 ENSMUST00000086006.11 ENSMUST00000086006.2 ENSMUST00000086006.3 ENSMUST00000086006.4 ENSMUST00000086006.5 ENSMUST00000086006.6 ENSMUST00000086006.7 ENSMUST00000086006.8 ENSMUST00000086006.9 NM_019940 Q99K53 Q99K53_MOUSE Zfp111 uc009foz.1 uc009foz.2 uc009foz.3 uc009foz.4 nucleic acid binding nucleus regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated metal ion binding uc009foz.1 uc009foz.2 uc009foz.3 uc009foz.4 
ENSMUST00000086013.5 ENSMUSG00000121793 ENSMUST00000086013.5 ENSMUSG00000121793 (from geneSymbol) AK007747 ENSMUST00000086013.1 ENSMUST00000086013.2 ENSMUST00000086013.3 ENSMUST00000086013.4 uc291mse.1 uc291mse.2 uc291mse.3 uc291mse.1 uc291mse.2 uc291mse.3 
ENSMUST00000086023.13 Galnt17 ENSMUST00000086023.13 polypeptide N-acetylgalactosaminyltransferase 17 (from RefSeq NM_145218.3) ENSMUST00000086023.1 ENSMUST00000086023.10 ENSMUST00000086023.11 ENSMUST00000086023.12 ENSMUST00000086023.2 ENSMUST00000086023.3 ENSMUST00000086023.4 ENSMUST00000086023.5 ENSMUST00000086023.6 ENSMUST00000086023.7 ENSMUST00000086023.8 ENSMUST00000086023.9 GLT17_MOUSE Galnt17 NM_145218 Q7TT15 Q8BKN7 Q8BUY1 Q8BX73 Q8BZC8 Q8K483 Wbscr17 uc008zuq.1 uc008zuq.2 uc008zuq.3 May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Evidence=; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TT15-1; Sequence=Displayed; Name=2; IsoId=Q7TT15-2; Sequence=VSP_011232; There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Name=Functional Glycomics Gateway - GTase; Note=Putative polypeptide N-acetylgalactosaminyltransferase-like protein 3; URL="http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=gt_mou_528"; Golgi membrane molecular_function polypeptide N-acetylgalactosaminyltransferase activity Golgi apparatus protein glycosylation biological_process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups carbohydrate binding metal ion binding uc008zuq.1 uc008zuq.2 uc008zuq.3 
ENSMUST00000086040.6 F5 ENSMUST00000086040.6 coagulation factor V (from RefSeq NM_007976.4) ENSMUST00000086040.1 ENSMUST00000086040.2 ENSMUST00000086040.3 ENSMUST00000086040.4 ENSMUST00000086040.5 FA5_MOUSE NM_007976 O88783 Q3UTQ2 Q3UV80 uc007dic.1 uc007dic.2 uc007dic.3 uc007dic.4 This gene encodes a glycoprotein coagulation factor that plays a critical role in the process of blood coagulation and hemostasis. The encoded protein is activated by thrombin, to generate a heterodimer containing heavy and light chains held together by calcium ions. About half of the mice lacking the encoded protein die at an embryonic stage possible due to abnormal yolk-sac vasculature while the remaining animals succumbed to massive hemorrhage immediately after birth. A point mutation in this gene has been shown to cause disseminated intravascular thrombosis in the perinatal period, resulting in frequent deaths of newborn mice. [provided by RefSeq, Apr 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK137537.1, U52925.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. Inhibited by SERPINA5. Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent. Forms heterodimer with SERPINA5 (By similarity). Secreted Domain B contains 32 X 9 AA tandem repeats, and 1 X 17 AA repeats. Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Activated protein C inactivates factor V and factor Va by proteolytic degradation. Belongs to the multicopper oxidase family. Sequence=BAE23393.1; Type=Erroneous initiation; Evidence=; copper ion binding extracellular region extracellular space endoplasmic reticulum Golgi apparatus blood coagulation hemostasis blood circulation platelet alpha granule metal ion binding uc007dic.1 uc007dic.2 uc007dic.3 uc007dic.4 
ENSMUST00000086041.7 Clasrp ENSMUST00000086041.7 CLK4-associating serine/arginine rich protein, transcript variant 4 (from RefSeq NR_125834.1) CLASR_MOUSE Clasp ENSMUST00000086041.1 ENSMUST00000086041.2 ENSMUST00000086041.3 ENSMUST00000086041.4 ENSMUST00000086041.5 ENSMUST00000086041.6 NR_125834 Q5RKW4 Q8CFC7 Q8CFC8 Q9Z2N3 Sfrs16 Srsf16 Swap2 uc009fml.1 uc009fml.2 uc009fml.3 uc009fml.4 The protein encoded by this gene contains serine/arginine (SR) dipeptide repeat domains, and is thought to be involved in the regulation of alternative splicing. This protein is thought to interact with, and be phosphorylated by, Clk4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family. Probably interacts with CLK4. Nucleus. Note=Located in nuclear dots. [Isoform 2]: Nucleus, nucleoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=L; IsoId=Q8CFC7-1; Sequence=Displayed; Name=2; Synonyms=S; IsoId=Q8CFC7-2; Sequence=VSP_008211, VSP_008212; Name=3; IsoId=Q8CFC7-3; Sequence=VSP_008213, VSP_008214; Highly expressed in brain. Expressed at intermediate level in lung and liver. In brain, it is expressed in the hippocampus, cerebellum and olfactory bulb. Phosphorylated in vitro by CLK4. Belongs to the splicing factor SR family. It is uncertain whether Met-1 or Met-16 is the initiator. Sequence=AAC82338.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB26225.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component nucleus nucleoplasm mRNA processing biological_process RNA splicing uc009fml.1 uc009fml.2 uc009fml.3 uc009fml.4 
ENSMUST00000086046.10 Nipsnap2 ENSMUST00000086046.10 nipsnap homolog 2, transcript variant 2 (from RefSeq NR_185194.1) ENSMUST00000086046.1 ENSMUST00000086046.2 ENSMUST00000086046.3 ENSMUST00000086046.4 ENSMUST00000086046.5 ENSMUST00000086046.6 ENSMUST00000086046.7 ENSMUST00000086046.8 ENSMUST00000086046.9 Gbas NR_185194 Nipsnap2 Q7TMG8 Q7TMG8_MOUSE uc008ztf.1 uc008ztf.2 uc008ztf.3 uc008ztf.4 Belongs to the NipSnap family. mitochondrion mitochondrial outer membrane oxidative phosphorylation mitochondrion organization uc008ztf.1 uc008ztf.2 uc008ztf.3 uc008ztf.4 
ENSMUST00000086050.4 Pramel40 ENSMUST00000086050.4 Belongs to the PRAME family. (from UniProt L7N456) ENSMUST00000086050.1 ENSMUST00000086050.2 ENSMUST00000086050.3 Gm6468 L7N456 L7N456_MOUSE Pramel40 uc290xff.1 uc290xff.2 uc290xff.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xff.1 uc290xff.2 uc290xff.3 
ENSMUST00000086056.8 Piwil1 ENSMUST00000086056.8 piwi-like RNA-mediated gene silencing 1 (from RefSeq NM_021311.3) A1L324 A1L325 ENSMUST00000086056.1 ENSMUST00000086056.2 ENSMUST00000086056.3 ENSMUST00000086056.4 ENSMUST00000086056.5 ENSMUST00000086056.6 ENSMUST00000086056.7 Miwi NM_021311 PIWL1_MOUSE Piwil1 Q6NXX0 Q9JMB7 uc008zsi.1 uc008zsi.2 uc008zsi.3 Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:11578866, PubMed:22121019, PubMed:21237665). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:11578866, PubMed:22121019, PubMed:21237665). Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:11578866, PubMed:22121019, PubMed:21237665). Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias) (PubMed:24757166). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle (PubMed:22121019). Acts as an endoribonuclease that cleaves transposon messenger RNAs (PubMed:22121019). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (PubMed:16938833). Probable component of some RISC complex, which mediates RNA cleavage and translational silencing (PubMed:16938833). Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (PubMed:16787948). Required to sequester RNF8 in the cytoplasm until late spermatogenesis; RNF8 being released upon ubiquitination and degradation of PIWIL1 (PubMed:28552346). Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts (via Piwi domain) with DICER1, suggesting that it forms ribonucleoprotein RISC complexes; this interaction is regulated by HSP90AB1 activity (PubMed:16938833). Interacts with MAEL, KIF17, PABPC1, PRMT5 and WDR77 (PubMed:16787948, PubMed:16787967, PubMed:19020299, PubMed:19584108). Interacts (when methylated on arginine residues) with TDRD1, TDRKH/TDRD2, RNF17/TDRD4, TDRD6, TDRD7 and TDRD9 (PubMed:19584108, PubMed:19918066, PubMed:19926723, PubMed:23714778). Interacts with CLOCK (PubMed:22900038). Interacts with MOV10L1 (PubMed:20534472). Interacts with ANAPC10; interaction oly takes place following piRNA-binding (PubMed:23328397). Interacts with RNF8; leading to sequester RNF8 in the cytoplasm (PubMed:28552346). Interacts with Tex19.1 and, probably, Tex19.2 (PubMed:28254886). Cytoplasm te=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JMB7-1; Sequence=Displayed; Name=2; IsoId=Q9JMB7-2; Sequence=VSP_036663; Expressed in brain. Expressed in testis, specifically in spermatocytes (at protein level). Only detected in germ lineage cells of adult testis. Expressed in male gonads 2 weeks after birth at the initiation of spermatogenesis, but not expressed in female gonads. Expression is activated by MYBL1/A-MYB. The D-box (destruction box) acts as a recognition signal for association with the APC/C complex, ubiquitination and degradation (PubMed:23328397). The PAZ domain specifically recognizes binds the 2'-O- methylated 3'-end of piRNAs (PubMed:21237665). The MID region is required for recognition of uridine in the first position of piRNAs (g1U preference, also named 1U-bias) (PubMed:24757166). Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) in late spermatids, leading to its degradation (PubMed:23328397). Ubiquitination only takes place following piRNA-binding in adult testis (PubMed:23328397). Ubiquitination and degradation in late spermatogenesis by APC/C is probably required to release RNF8 from the cytoplasm and promote histone to protamine exchange by RNF8 (PubMed:28552346). Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein (TDRD1, TDRKH/TDRD2, RNF17/TDRD4, TDRD6, TDRD7 and TDRD9) and subsequent localization to the meiotic nuage, also named P granule. Mice display spermatogenic arrest at the beginning of the round spermatid stage, resembling the phenotype of CREM, a master regulator of spermiogenesis; mRNAs of FHL5/activator of CREM and CREM target genes are down-regulated in testes. Female are fertile but male are completely sterile, no sperm is found in the epididimus. Chromatoid bodies from round spermatids are not fully compacted and remain as a diffuse chromatoid material. Belongs to the argonaute family. Piwi subfamily. Sequence=AAH66846.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; nucleic acid binding RNA binding single-stranded RNA binding mRNA binding nuclease activity endonuclease activity endoribonuclease activity protein binding nucleus cytoplasm cytosol regulation of translation multicellular organism development spermatogenesis spermatid development negative regulation of transposition hydrolase activity protein kinase binding cell differentiation gene silencing by RNA chromatoid body piRNA binding piRNA metabolic process spermatogenesis, exchange of chromosomal proteins P granule metal ion binding meiotic cell cycle nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic dense body polysome binding uc008zsi.1 uc008zsi.2 uc008zsi.3 
ENSMUST00000086075.13 Scarb1 ENSMUST00000086075.13 scavenger receptor class B, member 1, transcript variant 11 (from RefSeq NR_188758.1) D3Z2V4 ENSMUST00000086075.1 ENSMUST00000086075.10 ENSMUST00000086075.11 ENSMUST00000086075.12 ENSMUST00000086075.2 ENSMUST00000086075.3 ENSMUST00000086075.4 ENSMUST00000086075.5 ENSMUST00000086075.6 ENSMUST00000086075.7 ENSMUST00000086075.8 ENSMUST00000086075.9 NR_188758 Q3TZ42 Q4FK30 Q61009 Q9CWJ7 SCRB1_MOUSE Srb1 uc008zrd.1 uc008zrd.2 uc008zrd.3 Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (By similarity). Both isoform 1 and isoform 2 act as receptors for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:9254074, PubMed:9614139). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity). The C-terminal region binds to PDZK1. Cell membrane ulti-pass membrane protein Membrane, caveola ; Multi-pass membrane protein Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. [Isoform 1]: Cell membrane Membrane, caveola [Isoform 2]: Cell membrane Membrane, caveola Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SR-BI , SR-BI.1 ; IsoId=Q61009-1; Sequence=Displayed; Name=2; Synonyms=SR-BI.2 , SR-BII ; IsoId=Q61009-2; Sequence=VSP_058986; Expressed primarily in liver, ovary and adrenal gland, and, at lower levels in other non-placental steroidogenic tissues, including adipose tissue, mammary gland and testis (at protein level) (PubMed:8560269, PubMed:9254074, PubMed:9614139). Isoform 2 is expressed at lower levels than isoform 1 in liver, testis and adrenal gland (PubMed:9614139). At the mRNA, but not at the protein level, isoform 2 is the predominant isoform in testis (80%) (PubMed:9254074). Both isoform 1 and isoform 2 are up-regulated in response to adrenocorticotropic hormone (ACTH). N-glycosylated. The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds. Belongs to the CD36 family. lipopolysaccharide binding beta-amyloid binding phosphatidylserine binding lipopolysaccharide receptor activity endothelial cell proliferation cytoplasm plasma membrane integral component of plasma membrane caveola androgen biosynthetic process cholesterol catabolic process lipid transport phagocytosis, recognition high-density lipoprotein particle binding cell surface positive regulation of triglyceride biosynthetic process positive regulation of cholesterol storage regulation of phosphatidylcholine catabolic process phospholipid transport lipopolysaccharide transport membrane integral component of membrane low-density lipoprotein particle binding cholesterol transport microvillus membrane lipopolysaccharide-mediated signaling pathway detection of lipopolysaccharide cholesterol efflux apolipoprotein binding apolipoprotein A-I binding high-density lipoprotein particle remodeling low-density lipoprotein particle clearance high-density lipoprotein particle clearance vitamin transmembrane transport cholesterol homeostasis protein homodimerization activity intracellular membrane-bounded organelle blood vessel endothelial cell migration recognition of apoptotic cell reverse cholesterol transport adhesion of symbiont to host regulation of phagocytosis intestinal absorption positive regulation of nitric-oxide synthase activity triglyceride homeostasis high-density lipoprotein particle receptor activity cholesterol import uc008zrd.1 uc008zrd.2 uc008zrd.3 
ENSMUST00000086084.2 Tnfsf18 ENSMUST00000086084.2 tumor necrosis factor (ligand) superfamily, member 18 (from RefSeq NM_183391.4) ENSMUST00000086084.1 Gitrl NM_183391 Q7TNY2 Q7TS55 Q80YG2 TNF18_MOUSE uc007dfo.1 uc007dfo.2 uc007dfo.3 uc007dfo.4 Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up- regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315). Homotrimer. Homodimer. Q7TS55; O35714: Tnfrsf18; NbExp=4; IntAct=EBI-523345, EBI-523358; Q7TS55; Q7TS55: Tnfsf18; NbExp=4; IntAct=EBI-523345, EBI-523345; Cell membrane ingle-pass type II membrane protein Detected in immature and mature dendritic cells and in macrophages (at protein level). Detected in spleen, lung, heart, thymus, monocytes, macrophages, B-cells and dendritic cells. Up-regulated by exposure to bacterial lipopolysaccharide (LPS). N-glycosylated. Reduced levels of pro-inflammatory macrophages in the peritoneal cavity following injection with thioglycollate broth to induce peritonitis and reduced AGTR1 levels in spleen macrophages. Belongs to the tumor necrosis factor family. adaptive immune response T cell proliferation involved in immune response immune system process positive regulation of leukocyte migration cytokine activity tumor necrosis factor receptor binding protein binding extracellular space plasma membrane immune response cell surface positive regulation of macrophage chemotaxis membrane integral component of membrane tumor necrosis factor receptor superfamily binding tumor necrosis factor-mediated signaling pathway regulation of T cell proliferation positive regulation of tyrosine phosphorylation of STAT protein identical protein binding positive regulation of cell adhesion positive regulation of inflammatory response positive regulation of NF-kappaB transcription factor activity positive regulation of monocyte chemotaxis positive regulation of protein homodimerization activity negative regulation of T-helper 17 cell lineage commitment regulation of dendritic cell chemotaxis interleukin-10 production interleukin-12 production regulation of interferon-gamma production regulation of interleukin-6 production regulation of tumor necrosis factor production activated CD4-positive, alpha-beta T cell proliferation regulation of monocyte chemotactic protein-1 production regulation of CD40 signaling pathway uc007dfo.1 uc007dfo.2 uc007dfo.3 uc007dfo.4 
ENSMUST00000086112.8 Ap2s1 ENSMUST00000086112.8 adaptor-related protein complex 2, sigma 1 subunit (from RefSeq NM_198613.2) Ap2s1 ENSMUST00000086112.1 ENSMUST00000086112.2 ENSMUST00000086112.3 ENSMUST00000086112.4 ENSMUST00000086112.5 ENSMUST00000086112.6 ENSMUST00000086112.7 NM_198613 Q3UJ76 Q3UJ76_MOUSE uc012faj.1 uc012faj.2 uc012faj.3 Membrane Belongs to the adaptor complexes small subunit family. intracellular protein transport protein transport membrane vesicle-mediated transport membrane coat AP-2 adaptor complex clathrin adaptor activity clathrin-dependent endocytosis uc012faj.1 uc012faj.2 uc012faj.3 
ENSMUST00000086130.9 Sec16b ENSMUST00000086130.9 SEC16 homolog B, endoplasmic reticulum export factor, transcript variant 1 (from RefSeq NM_033354.3) E9QL61 ENSMUST00000086130.1 ENSMUST00000086130.2 ENSMUST00000086130.3 ENSMUST00000086130.4 ENSMUST00000086130.5 ENSMUST00000086130.6 ENSMUST00000086130.7 ENSMUST00000086130.8 Kiaa1928 Lztr2 NM_033354 Q69Z64 Q6PCR8 Q91XT4 Rgpr SC16B_MOUSE uc007ddm.1 uc007ddm.2 uc007ddm.3 uc007ddm.4 uc007ddm.5 Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes. SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. Interacts with TFG. Interacts with SEC13. Endoplasmic reticulum membrane ; Peripheral membrane protein Golgi apparatus membrane ; Peripheral membrane protein Note=Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Liver. Belongs to the SEC16 family. Sequence=BAD32580.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane molecular_function endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus ER to Golgi vesicle-mediated transport endoplasmic reticulum organization Golgi organization peroxisome organization positive regulation of gene expression ER to Golgi transport vesicle membrane protein transport membrane vesicle-mediated transport peroxisome fission intracellular membrane-bounded organelle COPII vesicle coating positive regulation of protein exit from endoplasmic reticulum endoplasmic reticulum exit site protein localization to endoplasmic reticulum exit site uc007ddm.1 uc007ddm.2 uc007ddm.3 uc007ddm.4 uc007ddm.5 
ENSMUST00000086145.10 6430550D23Rik ENSMUST00000086145.10 RIKEN cDNA 6430550D23 gene, transcript variant 5 (from RefSeq NM_001408015.1) 6430550D23Rik B7ZCN5 B7ZCN5_MOUSE ENSMUST00000086145.1 ENSMUST00000086145.2 ENSMUST00000086145.3 ENSMUST00000086145.4 ENSMUST00000086145.5 ENSMUST00000086145.6 ENSMUST00000086145.7 ENSMUST00000086145.8 ENSMUST00000086145.9 NM_001408015 uc008nlw.1 uc008nlw.2 uc008nlw.3 uc008nlw.4 uc008nlw.1 uc008nlw.2 uc008nlw.3 uc008nlw.4 
ENSMUST00000086148.8 Sult2a2 ENSMUST00000086148.8 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2 (from RefSeq NM_009286.2) ENSMUST00000086148.1 ENSMUST00000086148.2 ENSMUST00000086148.3 ENSMUST00000086148.4 ENSMUST00000086148.5 ENSMUST00000086148.6 ENSMUST00000086148.7 NM_009286 Q3UEP5 Q3UEP5_MOUSE Sult2a2 uc012ezq.1 uc012ezq.2 uc012ezq.3 This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK149424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Belongs to the sulfotransferase 1 family. sulfotransferase activity transferase activity uc012ezq.1 uc012ezq.2 uc012ezq.3 
ENSMUST00000086167.12 Nfrkb ENSMUST00000086167.12 nuclear factor related to kappa B binding protein, transcript variant 1 (from RefSeq NM_172766.4) ENSMUST00000086167.1 ENSMUST00000086167.10 ENSMUST00000086167.11 ENSMUST00000086167.2 ENSMUST00000086167.3 ENSMUST00000086167.4 ENSMUST00000086167.5 ENSMUST00000086167.6 ENSMUST00000086167.7 ENSMUST00000086167.8 ENSMUST00000086167.9 NFRKB_MOUSE NM_172766 Q6PIJ4 Q8BWV5 Q8K0X6 uc009orr.1 uc009orr.2 uc009orr.3 uc009orr.4 uc009orr.5 Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex (By similarity). Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Interacts with UCHL5 (By similarity). Nucleus NFRKB seems to be mostly disordered. The wing-helix like domain doesn't bind DNA (By similarity). Belongs to the NFRKB family. Sequence=BAC33927.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protease binding DNA binding nucleus DNA repair DNA recombination cellular response to DNA damage stimulus biological_process Ino80 complex uc009orr.1 uc009orr.2 uc009orr.3 uc009orr.4 uc009orr.5 
ENSMUST00000086195.7 Zfp648 ENSMUST00000086195.7 zinc finger protein 648, transcript variant 1 (from RefSeq NM_001204908.2) D3Z0W3 D3Z0W3_MOUSE ENSMUST00000086195.1 ENSMUST00000086195.2 ENSMUST00000086195.3 ENSMUST00000086195.4 ENSMUST00000086195.5 ENSMUST00000086195.6 NM_001204908 Zfp648 uc029qug.1 uc029qug.2 uc029qug.3 nucleic acid binding biological_process uc029qug.1 uc029qug.2 uc029qug.3 
ENSMUST00000086199.12 Glul ENSMUST00000086199.12 glutamate-ammonia ligase (from RefSeq NM_008131.5) ENSMUST00000086199.1 ENSMUST00000086199.10 ENSMUST00000086199.11 ENSMUST00000086199.2 ENSMUST00000086199.3 ENSMUST00000086199.4 ENSMUST00000086199.5 ENSMUST00000086199.6 ENSMUST00000086199.7 ENSMUST00000086199.8 ENSMUST00000086199.9 GLNA_MOUSE Glns Glul NM_008131 P15105 Q3TRK7 Q64432 Q91VC6 uc007daq.1 uc007daq.2 uc007daq.3 uc007daq.4 Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (PubMed:25870278). Essential for proliferation of fetal skin fibroblasts (By similarity). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development (PubMed:30158707). Involved in angiogenesis by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (By similarity). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Reaction=ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate; Xref=Rhea:RHEA:16169, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:456216; EC=6.3.1.2; Evidence=; Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Glutamine synthetase activity is inhibited by methionine sulfoximine (MSO). Decamer; composed of two pentamers (By similarity). Interacts with PALMD (PubMed:16323283). Interacts with RHOJ (By similarity). Cytoplasm, cytosol Microsome Mitochondrion Cell membrane ; Lipid-anchor Note=Mainly localizes in the cytosol, with a fraction associated with the cell membrane. Expressed in microvascular endothelial cells. Palmitoylated; undergoes autopalmitoylation. Ubiquitinated by ZNRF1. Embryonic lethality when embryos move from the uterine tube to the uterine environment (PubMed:17557305). Conditional deletion in the liver leads to a marked increase of plasma ammonia levels, causing increased locomotion, impaired fear memory and a slightly reduced life span (PubMed:25870278). Conditional deletion in endothelial cells impairs vessel sprouting during vascular development due to defects in endothelial cell migration (PubMed:30158707). Belongs to the glutamine synthetase family. nucleotide binding magnesium ion binding angiogenesis catalytic activity glutamate-ammonia ligase activity protein binding ATP binding cytoplasm mitochondrion endoplasmic reticulum rough endoplasmic reticulum cytosol plasma membrane glutamate metabolic process glutamine biosynthetic process nitrogen compound metabolic process cell proliferation cellular response to starvation response to glucose regulation of endothelial cell migration membrane glutamate binding transferase activity ligase activity protein palmitoylation ammonia assimilation cycle protein-cysteine S-palmitoyltransferase activity manganese ion binding positive regulation of insulin secretion macromolecular complex ribosome biogenesis identical protein binding cell projection neuron projection perikaryon myelin sheath intracellular membrane-bounded organelle axon terminus cell body dynein light chain binding metal ion binding positive regulation of epithelial cell proliferation protein homooligomerization positive regulation of synaptic transmission, glutamatergic glial cell projection regulation of sprouting angiogenesis regulation of protein localization to nucleolus uc007daq.1 uc007daq.2 uc007daq.3 uc007daq.4 
ENSMUST00000086209.10 Rnasel ENSMUST00000086209.10 ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) (from RefSeq NM_011882.2) ENSMUST00000086209.1 ENSMUST00000086209.2 ENSMUST00000086209.3 ENSMUST00000086209.4 ENSMUST00000086209.5 ENSMUST00000086209.6 ENSMUST00000086209.7 ENSMUST00000086209.8 ENSMUST00000086209.9 NM_011882 Q05921 Q9ERU7 RN5A_MOUSE Rns4 uc007dag.1 uc007dag.2 uc007dag.3 uc007dag.4 Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis. Might play a central role in the regulation of mRNA turnover (By similarity). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length (By similarity). Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Manganese or magnesium. Required for optimal RNA cleavage rates.; After binding to 2-5A (5'-phosphorylated 2',5'- linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNASEL inhibitor ABCE1/RLI, a cytoplasmic member of the ATP-binding cassette (ABC) transporter family (By similarity). (Microbial infection) Interacts (via N-terminus) with TMEV leader protein; this interaction prevents RNASEL activation by its substrate 2'-5' oligoadenylates. Monomer (inactive form) or homodimer. Interacts with ABCE1; this interaction inhibits the RNASEL (By similarity). Cytoplasm Mitochondrion Expressed in spleen, thymus, lung, testis, kidney, liver and heart. By interferons. Virus replication in higher vertebrates is restrained by IFNs that cause cells to transcribe genes encoding antiviral proteins, such as 2'-5' oligoadenylate synthetases (OASs). oligoadenylate synthetase is stimulated by dsRNA to produce 5'- phosphorylated, 2'-5'-linked oligoadenylates (2-5A), whose function is to activate RNASEL. The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain. The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization. The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is sufficient for ribonuclease activity. Belongs to the protein kinase superfamily. nucleotide binding RNA binding nuclease activity endonuclease activity ribonuclease activity protein kinase activity ATP binding cytoplasm mitochondrion rRNA processing mRNA processing protein phosphorylation nuclear matrix hydrolase activity rRNA binding identical protein binding ribonucleoprotein complex binding regulation of mRNA stability negative regulation of viral genome replication fat cell differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import metal ion binding defense response to virus nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis uc007dag.1 uc007dag.2 uc007dag.3 uc007dag.4 
ENSMUST00000086216.9 Anapc5 ENSMUST00000086216.9 anaphase-promoting complex subunit 5, transcript variant 1 (from RefSeq NM_021505.3) APC5_MOUSE ENSMUST00000086216.1 ENSMUST00000086216.2 ENSMUST00000086216.3 ENSMUST00000086216.4 ENSMUST00000086216.5 ENSMUST00000086216.6 ENSMUST00000086216.7 ENSMUST00000086216.8 MNCb-2778 NM_021505 Q3TGA7 Q80UJ6 Q80W43 Q8BTZ4 Q8BWW7 Q8C0F7 Q9CRX0 Q9CSL1 Q9JJB8 uc008zmg.1 uc008zmg.2 uc008zmg.3 uc008zmg.4 uc008zmg.5 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Protein modification; protein ubiquitination. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. Nucleus Cytoplasm, cytoskeleton, spindle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BTZ4-1; Sequence=Displayed; Name=2; IsoId=Q8BTZ4-2; Sequence=VSP_008472; Belongs to the APC5 family. Sequence=BAA95076.1; Type=Frameshift; Evidence=; nucleus anaphase-promoting complex cell cycle protein ubiquitination protein phosphatase binding anaphase-promoting complex-dependent catabolic process positive regulation of mitotic metaphase/anaphase transition cell division ubiquitin protein ligase activity protein K11-linked ubiquitination uc008zmg.1 uc008zmg.2 uc008zmg.3 uc008zmg.4 uc008zmg.5 
ENSMUST00000086278.7 Zfp810 ENSMUST00000086278.7 zinc finger protein 810, transcript variant 1 (from RefSeq NM_145612.3) BC005471 ENSMUST00000086278.1 ENSMUST00000086278.2 ENSMUST00000086278.3 ENSMUST00000086278.4 ENSMUST00000086278.5 ENSMUST00000086278.6 NM_145612 Q99K45 Q99K45_MOUSE Zfp810 uc009ooj.1 uc009ooj.2 molecular_function nucleic acid binding transcription factor activity, sequence-specific DNA binding cellular_component nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc009ooj.1 uc009ooj.2 
ENSMUST00000086281.5 Zfp599 ENSMUST00000086281.5 zinc finger protein 599, transcript variant 1 (from RefSeq NM_181419.4) E9PWP1 E9PWP1_MOUSE ENSMUST00000086281.1 ENSMUST00000086281.2 ENSMUST00000086281.3 ENSMUST00000086281.4 NM_181419 Zfp599 uc009ooh.1 uc009ooh.2 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc009ooh.1 uc009ooh.2 
ENSMUST00000086282.13 Vmn2r42 ENSMUST00000086282.13 vomeronasal 2, receptor 42 (from RefSeq NM_009493.2) ENSMUST00000086282.1 ENSMUST00000086282.10 ENSMUST00000086282.11 ENSMUST00000086282.12 ENSMUST00000086282.2 ENSMUST00000086282.3 ENSMUST00000086282.4 ENSMUST00000086282.5 ENSMUST00000086282.6 ENSMUST00000086282.7 ENSMUST00000086282.8 ENSMUST00000086282.9 NM_009493 O35192 O35192_MOUSE V2r4 VR4 Vmn2r42 uc009fcy.1 uc009fcy.2 uc009fcy.3 uc009fcy.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009fcy.1 uc009fcy.2 uc009fcy.3 uc009fcy.4 
ENSMUST00000086297.8 Vmn2r28 ENSMUST00000086297.8 vomeronasal 2, receptor 28 (from RefSeq NM_001081405.1) ENSMUST00000086297.1 ENSMUST00000086297.2 ENSMUST00000086297.3 ENSMUST00000086297.4 ENSMUST00000086297.5 ENSMUST00000086297.6 ENSMUST00000086297.7 L7N203 L7N203_MOUSE NM_001081405 Vmn2r28 uc009fai.1 uc009fai.2 uc009fai.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009fai.1 uc009fai.2 uc009fai.3 
ENSMUST00000086310.8 Sh2b3 ENSMUST00000086310.8 SH2B adaptor protein 3, transcript variant 3 (from RefSeq NM_001306127.2) ENSMUST00000086310.1 ENSMUST00000086310.2 ENSMUST00000086310.3 ENSMUST00000086310.4 ENSMUST00000086310.5 ENSMUST00000086310.6 ENSMUST00000086310.7 Lnk NM_001306127 O09039 SH2B3_MOUSE uc008zkh.1 uc008zkh.2 uc008zkh.3 uc008zkh.4 This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. Links T-cell receptor activation signal to phospholipase C- gamma-1, GRB2 and phosphatidylinositol 3-kinase. Tyrosine phosphorylated. Belongs to the SH2B adapter family. neutrophil homeostasis transmembrane receptor protein tyrosine kinase adaptor activity SH3/SH2 adaptor activity stem cell factor receptor binding protein binding plasma membrane signal transduction transmembrane receptor protein tyrosine kinase signaling pathway negative regulation of cell proliferation positive regulation of signal transduction hemopoiesis cell differentiation embryonic hemopoiesis intracellular signal transduction signaling adaptor activity monocyte homeostasis megakaryocyte development cellular response to interleukin-3 thrombopoietin-mediated signaling pathway negative regulation of tyrosine phosphorylation of STAT protein negative regulation of MAP kinase activity negative regulation of JAK-STAT cascade erythrocyte development negative regulation of protein kinase B signaling negative regulation of response to cytokine stimulus negative regulation of chemokine-mediated signaling pathway negative regulation of platelet aggregation negative regulation of Kit signaling pathway protein tyrosine kinase binding cellular response to chemokine uc008zkh.1 uc008zkh.2 uc008zkh.3 uc008zkh.4 
ENSMUST00000086325.13 Flywch1 ENSMUST00000086325.13 FLYWCH-type zinc finger 1, transcript variant 3 (from RefSeq NM_153791.2) E9QKQ2 ENSMUST00000086325.1 ENSMUST00000086325.10 ENSMUST00000086325.11 ENSMUST00000086325.12 ENSMUST00000086325.2 ENSMUST00000086325.3 ENSMUST00000086325.4 ENSMUST00000086325.5 ENSMUST00000086325.6 ENSMUST00000086325.7 ENSMUST00000086325.8 ENSMUST00000086325.9 FWCH1_MOUSE Kiaa1552 NM_153791 Q3TH83 Q6ZPN0 Q8C792 Q8CI03 uc008atj.1 uc008atj.2 uc008atj.3 uc008atj.4 Transcription cofactor. Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding. May play a role in DNA-damage response signaling. Binds specifically to DNA sequences at peri-centromeric chromatin loci. Interacts with CTNNB1 (when unphosphorylated), perhaps preventing interaction of CTNNB1 with TCF4, and thereby regulating transcription activation; phosphorylation of CTNNB1 may inhibit the interaction. Nucleus Chromosome, centromere Note=Localized to peri-centromeric, H3K9me3-marked heterochromatin. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CI03-1; Sequence=Displayed; Name=2; IsoId=Q8CI03-2; Sequence=VSP_030283; Name=3; IsoId=Q8CI03-3; Sequence=VSP_030282; Sequence=BAE40315.1; Type=Frameshift; Evidence=; molecular_function DNA binding nucleus nucleoplasm cytosol biological_process nuclear body metal ion binding uc008atj.1 uc008atj.2 uc008atj.3 uc008atj.4 
ENSMUST00000086327.12 Zfp667 ENSMUST00000086327.12 zinc finger protein 667 (from RefSeq NM_001024928.2) B2RUH6 ENSMUST00000086327.1 ENSMUST00000086327.10 ENSMUST00000086327.11 ENSMUST00000086327.2 ENSMUST00000086327.3 ENSMUST00000086327.4 ENSMUST00000086327.5 ENSMUST00000086327.6 ENSMUST00000086327.7 ENSMUST00000086327.8 ENSMUST00000086327.9 Mip1 NM_001024928 Q2TL60 ZN667_MOUSE Znf667 uc009fbb.1 uc009fbb.2 uc009fbb.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009fbb.1 uc009fbb.2 uc009fbb.3 
ENSMUST00000086338.2 Vmn1r65 ENSMUST00000086338.2 vomeronasal 1 receptor 65 (from RefSeq NM_030738.2) ENSMUST00000086338.1 NM_030738 Q9EPS7 Q9EPS7_MOUSE V1RC3 V1rd6 Vmn1r65 uc009fam.1 uc009fam.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009fam.1 uc009fam.2 
ENSMUST00000086341.12 Nlrp5 ENSMUST00000086341.12 NLR family, pyrin domain containing 5, transcript variant 2 (from RefSeq NM_001039143.2) ENSMUST00000086341.1 ENSMUST00000086341.10 ENSMUST00000086341.11 ENSMUST00000086341.2 ENSMUST00000086341.3 ENSMUST00000086341.4 ENSMUST00000086341.5 ENSMUST00000086341.6 ENSMUST00000086341.7 ENSMUST00000086341.8 ENSMUST00000086341.9 Mater NALP5_MOUSE NM_001039143 Nalp5 Q3UXD0 Q53ZD5 Q6VSF9 Q6VSG0 Q6VSG1 Q6VSG2 Q6VSG3 Q6VSG4 Q6VSG5 Q6XZF2 Q7TPU9 Q9JLR2 Q9R1M5 uc009fof.1 uc009fof.2 uc009fof.3 uc009fof.4 This gene encodes a member of the NACHT, leucine-rich repeat, and pyrin domain containing family. Members of this family have a pyrin domain at the N-terminus, a central NACHT domain, and a C-terminal leucine-rich repeat domain. This gene encodes a maternal-effect factor that is essential for early embryonic development in the mouse. Homozygous null mutant females are sterile, and embryos die following the first cleavage. This gene is required for endoplasmic reticulum redistribution and calcium homeostasis in oocytes. In addition, ovulated oocytes mutant for this gene have abnormal mitochondrial localization and increased mitochondrial activity, which results in mitochondrial damage and early embryonic lethality. Pseudogenes of this gene have been found on chromosomes 7 and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:11062459, PubMed:18804437, PubMed:25208553). Required for the formation of F- actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (PubMed:25208553). Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold (PubMed:31118423). Required for cortical actin clearance prior to oocyte exocytosis and prevention of polyspermy (PubMed:31118423). Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum storage (ER) storage via regulation of cellular localization (PubMed:24374158). May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation (PubMed:22357545). Component of the subcortical maternal complex (SCMC), at least composed of NLRP5, KHDC3, OOEP, and TLE6 (PubMed:18804437, PubMed:28992324, PubMed:31575650). Within the complex, interacts with OOEP, KHDC3 and TLE6 (PubMed:18804437, PubMed:28992324, PubMed:31575650). The SCMC may facilitate translocation of its components between the nuclear and cytoplasmic compartments (By similarity). As part of the SCMC interacts with the SCMC-associated protein ZBED3 (PubMed:28992324). As part of the SCMC interacts with the SCMC-associated protein CFL1/Cofilin-1 (PubMed:25208553). Interacts with PRKCE (By similarity). Interacts with TUBB3 at cytoskeleton microtubules (PubMed:24374158). Q9R1M5; Q9CWU5: Khdc3; NbExp=3; IntAct=EBI-2905719, EBI-2905804; Cytoplasmic vesicle, secretory vesicle, Cortical granule Mitochondrion Nucleus, nucleolus Cytoplasm lgi apparatus Note=Located in mitochondria and nucleoli in primary follicle oocytes (PubMed:14670992). Colocalizes with ZBED3 and NLRP4F in the oocyte subcortex (PubMed:25208553, PubMed:28992324, PubMed:31575650). Not detected in oocyte mitochondria in type 2 follicles (PubMed:14670992). In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages (PubMed:14670992, PubMed:25208553). From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (PubMed:14670992). Expression largely disappears in blastocysts (PubMed:25208553). Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=D; IsoId=Q9R1M5-1; Sequence=Displayed; Name=2; Synonyms=C; IsoId=Q9R1M5-2; Sequence=VSP_024728; Name=3; Synonyms=B; IsoId=Q9R1M5-3; Sequence=VSP_024727; Name=4; Synonyms=A; IsoId=Q9R1M5-4; Sequence=VSP_024726; Name=5; Synonyms=E; IsoId=Q9R1M5-5; Sequence=VSP_024727, VSP_024729; Name=6; Synonyms=G; IsoId=Q9R1M5-6; Sequence=VSP_024727, VSP_024733; Name=7; Synonyms=H; IsoId=Q9R1M5-7; Sequence=VSP_024727, VSP_024731, VSP_024732; Name=8; Synonyms=F; IsoId=Q9R1M5-8; Sequence=VSP_024727, VSP_024730; Expression is first detected in oocytes of type 3A primary follicles (PubMed:14670992, PubMed:31118423). Transcripts accumulate during oogenesis (PubMed:14670992). Expressed in the cytoplasm of germinal vesicle oocytes before becoming concentrated in the subcortex of metaphase 2 oocytes (PubMed:28992324, PubMed:31118423). During meiotic maturation, the vast majority of the transcripts are degraded and virtually none is detected by 2-cell stage embryogenesis (PubMed:14670992, PubMed:18804437). The protein however persists during preimplantation up to the blastocyst stage (PubMed:14670992, PubMed:18804437). At 2-cell stage, excluded from cell-cell contact regions (PubMed:18804437). Continuous exclusion from these regions during preimplantation development leads to the absence of the protein from the inner cells of the morula and the inner cell mass of the blastocyst (PubMed:18804437). Expressed in ovaries at birth, expression peaks at postnatal day 10 (P10), expression is then decreased at P17 and further decreased at P21 (PubMed:10433232, PubMed:31575650). (Microbial infection) Reduced by T.gondii in the testes and uterus. Phosphorylated by PRKCE. Mice appear phenotypically normal with no apparent defects in ovarian development, oocyte maturation or ovulation (PubMed:14670992, PubMed:22357545). Cortical granules are scattered throughout the cytoplasm in oocytes and ovulated eggs (PubMed:31118423). Reduced abundance of intact MYH9/MyoIIA and MYO5A, the dense cortical actin scaffold remained present prior to exocytosis (PubMed:31118423). Increase in polyspermy in the perivitelline space resulting from a decrease in efficacy of the zona pellucida block. Increase in multiple pronuclei and delay in cortical granule exocytosis and ZP2 cleavage (PubMed:31118423). Embryos form unequal sized blastomeres due to smaller, dysmorphic, and displaced mitotic spindles resulting in asymmetric division (PubMed:25208553). Increase in apoptotic cells in blastomeres which progress beyond the 8-cell stage (PubMed:22357545). Decrease in thickness of subcortical F-actin in zygotes, thickening of F-actin bundles in the cytoplasm and loss of F- actin cytoplasmic lattices (PubMed:25208553). Increase in subcortical mitochondrial clustering of mitochondria in 2-cell embryos (PubMed:22357545). Increase in mitochondria activity, shown by an increase in membrane potential and reactive oxygen species (PubMed:22357545). Decrease in expression of the SCMC-associated protein ZBED3 in the cytoplasm of oocytes (PubMed:28992324). In knockdown mice M2 oocytes show a diffuse ER distribution pattern with a reduced number of cortical ER clusters and random movement of lipid droplets during oocyte maturation (PubMed:24374158). Reduces tubulin localization to the cellular microtubular architecture (PubMed:24374158). Decrease in storage and release of Ca(2+) from the endoplasmic reticulum, and disruption of Ca(2+) oscillations following oocyte fertilization (PubMed:24374158). diffused localization of ITPR1/IP3R-1 throughout the cytoplasm with reduced clustering at the oocyte cortex (PubMed:24374158). Belongs to the NLRP family. nucleotide binding in utero embryonic development protein binding ATP binding nucleus nucleolus cytoplasm mitochondrion cytosol cell cortex embryo implantation fertilization animal organ morphogenesis regulation of protein stability macromolecular complex cellular protein localization cellular macromolecular complex assembly regulation of RNA stability apical cortex uc009fof.1 uc009fof.2 uc009fof.3 uc009fof.4 
ENSMUST00000086361.13 AB124611 ENSMUST00000086361.13 cDNA sequence AB124611, transcript variant 1 (from RefSeq NM_001198794.2) ENSMUST00000086361.1 ENSMUST00000086361.10 ENSMUST00000086361.11 ENSMUST00000086361.12 ENSMUST00000086361.2 ENSMUST00000086361.3 ENSMUST00000086361.4 ENSMUST00000086361.5 ENSMUST00000086361.6 ENSMUST00000086361.7 ENSMUST00000086361.8 ENSMUST00000086361.9 HIDE1_MOUSE Hide1 NM_001198794 Q75VT7 Q75VT8 uc009olt.1 uc009olt.2 uc009olt.3 uc009olt.4 uc009olt.5 Membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q75VT8-1; Sequence=Displayed; Name=2; Synonyms=SHIDE1; IsoId=Q75VT8-2; Sequence=VSP_034226; molecular_function cellular_component biological_process membrane integral component of membrane uc009olt.1 uc009olt.2 uc009olt.3 uc009olt.4 uc009olt.5 
ENSMUST00000086363.5 Tmem150b ENSMUST00000086363.5 transmembrane protein 150B, transcript variant 1 (from RefSeq NM_001142792.1) ENSMUST00000086363.1 ENSMUST00000086363.2 ENSMUST00000086363.3 ENSMUST00000086363.4 NM_001142792 Q8C9L9 Q8R218 T150B_MOUSE Tmem150b uc009eyh.1 uc009eyh.2 uc009eyh.3 uc009eyh.4 Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (By similarity). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy- independent manner (By similarity). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (By similarity). Cell membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein Note=Localizes mainly at the plasma membrane where it concentrates at actin-rich focal adhesions (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R218-1; Sequence=Displayed; Name=2; IsoId=Q8R218-2; Sequence=VSP_035310, VSP_035311; Belongs to the DRAM/TMEM150 family. autophagosome membrane molecular_function lysosome endosome plasma membrane integral component of plasma membrane autophagy endosome membrane regulation of autophagy membrane integral component of membrane cytoplasmic vesicle uc009eyh.1 uc009eyh.2 uc009eyh.3 uc009eyh.4 
ENSMUST00000086368.12 Oas1g ENSMUST00000086368.12 2'-5' oligoadenylate synthetase 1G, transcript variant 2 (from RefSeq NR_126529.1) ENSMUST00000086368.1 ENSMUST00000086368.10 ENSMUST00000086368.11 ENSMUST00000086368.2 ENSMUST00000086368.3 ENSMUST00000086368.4 ENSMUST00000086368.5 ENSMUST00000086368.6 ENSMUST00000086368.7 ENSMUST00000086368.8 ENSMUST00000086368.9 NR_126529 Oas1g Q8K469 Q8K469_MOUSE uc008zii.1 uc008zii.2 uc008zii.3 uc008zii.4 This gene encodes a member of the oligoadenylate synthetase family of proteins. This gene and several other family members are present in a gene cluster on chromosome 5. These proteins are believed to function in antiviral immunity through binding to viral dsRNA and subsequent synthesis of 2'-5'-oligoadenylates. The expression of this gene has been shown to be induced by interferon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]. Reaction=3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')- adenosine + 2 diphosphate; Xref=Rhea:RHEA:34407, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:67143; EC=2.7.7.84; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm Belongs to the 2-5A synthase family. 2'-5'-oligoadenylate synthetase activity RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm cytoplasm cytosol immune response transferase activity nucleotidyltransferase activity negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity uc008zii.1 uc008zii.2 uc008zii.3 uc008zii.4 
ENSMUST00000086370.11 Pierce1 ENSMUST00000086370.11 piercer of microtubule wall 1 (from RefSeq NM_027040.1) ENSMUST00000086370.1 ENSMUST00000086370.10 ENSMUST00000086370.2 ENSMUST00000086370.3 ENSMUST00000086370.4 ENSMUST00000086370.5 ENSMUST00000086370.6 ENSMUST00000086370.7 ENSMUST00000086370.8 ENSMUST00000086370.9 NM_027040 PIRC1_MOUSE Pierce1 Q5BN45 uc008iyf.1 uc008iyf.2 uc008iyf.3 Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme (PubMed:34715025). Functions at the initial step of left- right asymmetry specification of the visceral organs (PubMed:27305836). Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme. Cytoplasm, cytoskeleton, cilium axoneme Expressed in brain, lung, kidney and testis. At 8 dpc, strongly expressed in the node area (PubMed:27305836). May be up-regulated during progression from G1 to S phase of the cell cycle. Maximal expression in S or G2 phase. By p53/TP53. Protein levels are stabilized following gamma- irradiation. Mutant mice exhibit severe laterality defects, including situs inversus totalis and heterotaxy with randomized situs and left and right isomerisms (PubMed:27305836, PubMed:34715025). They show partial embryonic lethality associated with heterotaxia (PubMed:27305836, PubMed:34715025). The motility of tracheal cilia in adult mice is also affected (PubMed:34715025). At 8 dpc, they have a reduced beat frequency of nodal cilia (PubMed:34715025). 50% of tracheal cilia axonemes have missing dynein arms (PubMed:34715025). Double PIERCE1 and PIERCE2 mutants show high levels of embryonic and pre-weaning lethality. The few mice that survive birth display hydrocephalus and laterality abnormalities, dying by 20 days of age (PubMed:34715025). Belongs to the PIERCE1 family. molecular_function nucleus cellular response to DNA damage stimulus determination of left/right symmetry regulation of gene expression cellular response to UV-C uc008iyf.1 uc008iyf.2 uc008iyf.3 
ENSMUST00000086395.7 Gpr25 ENSMUST00000086395.7 G protein-coupled receptor 25 (from RefSeq NM_001101516.2) ENSMUST00000086395.1 ENSMUST00000086395.2 ENSMUST00000086395.3 ENSMUST00000086395.4 ENSMUST00000086395.5 ENSMUST00000086395.6 GPR25_MOUSE Gm1300 NM_001101516 P0C5I1 uc011wsy.1 uc011wsy.2 uc011wsy.3 Orphan receptor. Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc011wsy.1 uc011wsy.2 uc011wsy.3 
ENSMUST00000086399.6 Icam1 ENSMUST00000086399.6 intercellular adhesion molecule 1 (from RefSeq NM_010493.3) ENSMUST00000086399.1 ENSMUST00000086399.2 ENSMUST00000086399.3 ENSMUST00000086399.4 ENSMUST00000086399.5 Icam1 NM_010493 Q3U8M7 Q3U8M7_MOUSE uc009ojx.1 uc009ojx.2 uc009ojx.3 uc009ojx.4 This gene encodes an integral membrane protein that binds leukocyte adhesion protein LFA-1. It participates in the innate immune response. [provided by RefSeq, Aug 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008626.1, AK152155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Homodimer. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells. Membrane ; Single- pass type I membrane protein Belongs to the immunoglobulin superfamily. ICAM family. T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of cellular extravasation integrin binding extracellular space cell adhesion leukocyte cell-cell adhesion membrane integral component of membrane membrane to membrane docking adhesion of symbiont to host receptor-mediated virion attachment to host cell leukocyte migration establishment of endothelial barrier extracellular exosome positive regulation of ERK1 and ERK2 cascade cell-cell adhesion negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cellular response to beta-amyloid negative regulation of endothelial cell apoptotic process uc009ojx.1 uc009ojx.2 uc009ojx.3 uc009ojx.4 
ENSMUST00000086401.10 Lair1 ENSMUST00000086401.10 leukocyte-associated Ig-like receptor 1, transcript variant g (from RefSeq NM_001302682.1) ENSMUST00000086401.1 ENSMUST00000086401.2 ENSMUST00000086401.3 ENSMUST00000086401.4 ENSMUST00000086401.5 ENSMUST00000086401.6 ENSMUST00000086401.7 ENSMUST00000086401.8 ENSMUST00000086401.9 LAIR1_MOUSE NM_001302682 Q80UN5 Q8BG84 Q8BHB6 Q8BRR6 Q8C6N8 Q8CEP5 uc009ewt.1 uc009ewt.2 uc009ewt.3 uc009ewt.4 Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T- cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity). Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK. Binds with high affinity to extracellular matrix collagens, the interaction is functionally important (By similarity). Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=mLair-1a; IsoId=Q8BG84-1; Sequence=Displayed; Name=2; Synonyms=mLair-1b; IsoId=Q8BG84-2; Sequence=VSP_020716; Name=3; IsoId=Q8BG84-3; Sequence=VSP_020714, VSP_020719; Name=5; Synonyms=mLair-1d; IsoId=Q8BG84-5; Sequence=VSP_020715; Name=6; Synonyms=mLair-1e; IsoId=Q8BG84-6; Sequence=VSP_020718; Expressed in lymphoid organs and in cell lines of hemopoietic origin. ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, leading to down-regulation of cell activation. Phosphorylation at Tyr-228 and Tyr-257 activates it. May be phosphorylated by LCK (By similarity). N-glycosylated. [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=BAC25505.1; Type=Frameshift; Evidence=; Sequence=BAC31610.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; Sequence=BAC35674.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; plasma membrane membrane integral component of membrane uc009ewt.1 uc009ewt.2 uc009ewt.3 uc009ewt.4 
ENSMUST00000086421.9 Nck2 ENSMUST00000086421.9 non-catalytic region of tyrosine kinase adaptor protein 2 (from RefSeq NM_010879.3) ENSMUST00000086421.1 ENSMUST00000086421.2 ENSMUST00000086421.3 ENSMUST00000086421.4 ENSMUST00000086421.5 ENSMUST00000086421.6 ENSMUST00000086421.7 ENSMUST00000086421.8 Grb4 NCK2_MOUSE NM_010879 O55033 uc007avo.1 uc007avo.2 uc007avo.3 uc007avo.4 Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling (By similarity). Interacts with DOCK1, LIMS1 and TGFB1I1. Part of a complex containing PPP1R15B, PP1 and NCK2. Interacts with FASLG. Interacts with AXL. Interacts with PAK1, PKN2 and SOS1. Interacts (via SH2 domain) with EGFR. Interacts (via SH2 domain) with DDR1 (By similarity). Cytoplasm Endoplasmic reticulum immunological synapse formation phosphotyrosine binding SH3/SH2 adaptor activity cytoplasm endoplasmic reticulum cytosol regulation of translation actin filament organization vesicle membrane postsynaptic density cell migration lamellipodium assembly positive regulation of actin filament polymerization negative regulation of peptidyl-serine phosphorylation positive regulation of translation in response to endoplasmic reticulum stress positive regulation of T cell proliferation macromolecular complex binding synapse positive regulation of transcription from RNA polymerase II promoter ephrin receptor signaling pathway dendritic spine development scaffold protein binding positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of PERK-mediated unfolded protein response negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress uc007avo.1 uc007avo.2 uc007avo.3 uc007avo.4 
ENSMUST00000086423.6 Kpna2rt ENSMUST00000086423.6 Functions in nuclear protein import. (from UniProt Q52L97) ENSMUST00000086423.1 ENSMUST00000086423.2 ENSMUST00000086423.3 ENSMUST00000086423.4 ENSMUST00000086423.5 Kpna2 LF193870 Q52L97 Q52L97_MOUSE uc289nlh.1 uc289nlh.2 Functions in nuclear protein import. Belongs to the importin alpha family. nucleus cytoplasm protein import into nucleus protein transport nuclear import signal receptor activity uc289nlh.1 uc289nlh.2 
ENSMUST00000086430.5 Col5a2 ENSMUST00000086430.5 collagen, type V, alpha 2 (from RefSeq NM_007737.2) CO5A2_MOUSE Col5a2 ENSMUST00000086430.1 ENSMUST00000086430.2 ENSMUST00000086430.3 ENSMUST00000086430.4 NM_007737 Q3TVR2 Q3U962 Q3UHK7 Q3UTT4 Q3V1J6 Q61431 Q7TMS0 Q80VS8 uc007awr.1 uc007awr.2 uc007awr.3 This gene encodes the alpha-2 subunit of type V collagen, one of the low abundance fibrillar collagens that gets incorporated into growing fibrils with type I collagen. The encoded protein, in association with alpha-1 and/or alpha-3 subunits, forms homo- or heterotrimeric type V procollagen that undergoes proteolytic processing. Mice lacking the encoded protein die in utero. Transgenic mice that produce a structurally abnormal form of the encoded protein survive poorly and exhibit skin fragility, skeletal abnormalities and alterations in the collagen fiber organization. [provided by RefSeq, Dec 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK139130.1, AK132413.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices. Trimers of two alpha 1(V) and one alpha 2(V) chains expressed in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains with a more limited distribution of expression. Secreted, extracellular space, extracellular matrix Expressed in embryos from 9 days of gestation onward. In 12.5 dpc embryos, low and diffuse level of expression was observed in the peritoneal membranes and intestinal and craniofacial mesenchymes. By 16.5 dpc, expression is higher and exhibits a more restricted accumulation in primary ossified regions, perichondrium, joints, tendon, atrioventricular valve of heart, and in selected portions of the head. The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity). Prolines at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Probably 3- hydroxylated on prolines by LEPREL1. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4- hydroxylation in vertebrates. Mice homozygous for the targeted deletion of the N- terminal telopeptide segment of the COL5A2 chain show poor survival rates, possibly because of complications from spinal deformities, and exhibit skin and eye abnormalities caused by disorganized type I collagen fibrils. The alpha 1(V)-alpha 1(V)-alpha 2(V) heterotrimer makes a critical contribution to fibrillogenesis, basement membrane organization, and cell viability, and may play a possible role in the development of a functional skin matrix. Belongs to the fibrillar collagen family. Sequence=BAE23896.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; skeletal system development ossification extracellular matrix structural constituent extracellular region collagen trimer collagen type V trimer extracellular space extracellular matrix structural constituent conferring tensile strength extracellular matrix organization collagen fibril organization extracellular matrix skin development SMAD binding metal ion binding eye morphogenesis cellular response to amino acid stimulus negative regulation of endodermal cell differentiation uc007awr.1 uc007awr.2 uc007awr.3 
ENSMUST00000086461.13 Rfc5 ENSMUST00000086461.13 replication factor C (activator 1) 5 (from RefSeq NM_028128.1) ENSMUST00000086461.1 ENSMUST00000086461.10 ENSMUST00000086461.11 ENSMUST00000086461.12 ENSMUST00000086461.2 ENSMUST00000086461.3 ENSMUST00000086461.4 ENSMUST00000086461.5 ENSMUST00000086461.6 ENSMUST00000086461.7 ENSMUST00000086461.8 ENSMUST00000086461.9 NM_028128 Q9D0F6 RFC5_MOUSE uc008zfs.1 uc008zfs.2 uc008zfs.3 The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA (By similarity). Nucleus Belongs to the activator 1 small subunits family. nucleotide binding DNA binding DNA clamp loader activity ATP binding nucleus DNA replication factor C complex DNA replication DNA-dependent DNA replication single-stranded DNA-dependent ATP-dependent DNA helicase activity enzyme binding Ctf18 RFC-like complex DNA duplex unwinding positive regulation of DNA-directed DNA polymerase activity uc008zfs.1 uc008zfs.2 uc008zfs.3 
ENSMUST00000086464.8 Vsig10 ENSMUST00000086464.8 Vsig10 (from geneSymbol) AK140339 E9PVW4 E9PVW4_MOUSE ENSMUST00000086464.1 ENSMUST00000086464.2 ENSMUST00000086464.3 ENSMUST00000086464.4 ENSMUST00000086464.5 ENSMUST00000086464.6 ENSMUST00000086464.7 Vsig10 uc290yyd.1 uc290yyd.2 membrane integral component of membrane uc290yyd.1 uc290yyd.2 
ENSMUST00000086465.6 Adora1 ENSMUST00000086465.6 adenosine A1 receptor, transcript variant 5 (from RefSeq NM_001291930.1) AA1R_MOUSE ENSMUST00000086465.1 ENSMUST00000086465.2 ENSMUST00000086465.3 ENSMUST00000086465.4 ENSMUST00000086465.5 NM_001291930 Q60612 Q8BGU7 Q9WUF9 uc007crk.1 uc007crk.2 uc007crk.3 uc007crk.4 Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Sequence=AAA18999.1; Type=Erroneous initiation; Evidence=; activation of MAPKK activity G-protein coupled adenosine receptor activity temperature homeostasis G-protein coupled receptor binding response to hypoxia purine nucleoside binding adenosine receptor signaling pathway regulation of respiratory gaseous exchange by neurological system process negative regulation of acute inflammatory response negative regulation of leukocyte migration positive regulation of peptide secretion positive regulation of systemic arterial blood pressure negative regulation of systemic arterial blood pressure regulation of glomerular filtration G-protein coupled receptor activity protein binding endoplasmic reticulum plasma membrane protein targeting to membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway negative regulation of cell proliferation endomembrane system negative regulation of glutamate secretion postsynaptic density membrane integral component of membrane lipid catabolic process basolateral plasma membrane dendrite axolemma heat shock protein binding G-protein beta/gamma-subunit complex binding negative regulation of synaptic transmission, GABAergic positive regulation of nucleoside transport asymmetric synapse heterotrimeric G-protein binding negative regulation of neurotrophin production positive regulation of protein dephosphorylation negative regulation of renal sodium excretion negative regulation of circadian sleep/wake cycle, sleep negative regulation of circadian sleep/wake cycle, non-REM sleep presynaptic membrane neuronal cell body negative regulation of apoptotic process terminal bouton dendritic spine positive regulation of potassium ion transport cell body calyx of Held synapse postsynaptic membrane positive regulation of epidermal growth factor-activated receptor activity negative regulation of blood pressure positive regulation of blood pressure negative regulation of heart contraction negative regulation of hormone secretion protein heterodimerization activity presynaptic active zone negative regulation of inflammatory response cognition detection of temperature stimulus involved in sensory perception of pain negative regulation of lipid catabolic process positive regulation of lipid catabolic process regulation of sensory perception of pain negative regulation of synaptic transmission, glutamatergic fatty acid homeostasis regulation of cardiac muscle contraction excitatory postsynaptic potential relaxation of vascular smooth muscle negative regulation of mucus secretion triglyceride homeostasis regulation of cardiac muscle cell contraction integral component of postsynaptic membrane integral component of presynaptic membrane regulation of presynaptic cytosolic calcium ion concentration neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration negative regulation of long-term synaptic potentiation negative regulation of long term synaptic depression positive regulation of neuron death uc007crk.1 uc007crk.2 uc007crk.3 uc007crk.4 
ENSMUST00000086471.12 Suds3 ENSMUST00000086471.12 suppressor of defective silencing 3 homolog (S. cerevisiae), transcript variant 1 (from RefSeq NM_178622.5) ENSMUST00000086471.1 ENSMUST00000086471.10 ENSMUST00000086471.11 ENSMUST00000086471.2 ENSMUST00000086471.3 ENSMUST00000086471.4 ENSMUST00000086471.5 ENSMUST00000086471.6 ENSMUST00000086471.7 ENSMUST00000086471.8 ENSMUST00000086471.9 NM_178622 Q3UC92 Q6P6K1 Q7TNT0 Q8BR65 Q8BRR7 Q8K5B4 SDS3_MOUSE Sds3 uc008zff.1 uc008zff.2 uc008zff.3 uc008zff.4 uc008zff.5 Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). Interacts with HCFC1 (By similarity). Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with USP17L2; the interaction is direct (By similarity). Interacts with FOXK2 (By similarity). Q8BR65; Q60520: Sin3a; NbExp=4; IntAct=EBI-591431, EBI-349034; Q8BR65; Q62141: Sin3b; NbExp=5; IntAct=EBI-591431, EBI-591450; Q8BR65; Q8BR65: Suds3; NbExp=3; IntAct=EBI-591431, EBI-591431; Nucleus Expressed in all newborn tissues tested, including brain, kidney and liver. The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms. Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains (By similarity). Belongs to the SDS3 family. negative regulation of transcription from RNA polymerase II promoter blastocyst hatching protein binding nucleus cytosol chromatin organization apoptotic process histone deacetylation Sin3 complex nuclear body enzyme binding identical protein binding protein homodimerization activity histone deacetylase binding positive regulation of apoptotic process negative regulation of transcription, DNA-templated Sin3-type complex histone deacetylase activity uc008zff.1 uc008zff.2 uc008zff.3 uc008zff.4 uc008zff.5 
ENSMUST00000086474.6 Or7e176 ENSMUST00000086474.6 olfactory receptor family 7 subfamily E member 176 (from RefSeq NM_146560.2) E9PVW2 E9PVW2_MOUSE ENSMUST00000086474.1 ENSMUST00000086474.2 ENSMUST00000086474.3 ENSMUST00000086474.4 ENSMUST00000086474.5 NM_146560 Olfr872 Or7e176 uc009oif.1 uc009oif.2 uc009oif.3 uc009oif.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. CCDS Note: The coding region has been updated to extend the N-terminus to one that is supported by available conservation data. ##Evidence-Data-START## Transcript exon combination :: DR065537.1, DR065882.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oif.1 uc009oif.2 uc009oif.3 uc009oif.4 
ENSMUST00000086482.4 Or7e169 ENSMUST00000086482.4 olfactory receptor family 7 subfamily E member 169 (from RefSeq NM_146528.2) ENSMUST00000086482.1 ENSMUST00000086482.2 ENSMUST00000086482.3 NM_146528 Olfr860 Or7e169 Q8VFF7 Q8VFF7_MOUSE uc009ohw.1 uc009ohw.2 uc009ohw.3 uc009ohw.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DR065571.1, CB173231.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ohw.1 uc009ohw.2 uc009ohw.3 uc009ohw.4 
ENSMUST00000086492.2 Or7g12 ENSMUST00000086492.2 olfactory receptor family 7 subfamily G member 12 (from RefSeq NM_001011823.1) ENSMUST00000086492.1 NM_001011823 Olfr834 Or7g12 Q7TRG8 Q7TRG8_MOUSE uc009ohb.1 uc009ohb.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ohb.1 uc009ohb.2 
ENSMUST00000086519.12 Rplp0 ENSMUST00000086519.12 ribosomal protein lateral stalk subunit P0 (from RefSeq NM_007475.5) Arbp ENSMUST00000086519.1 ENSMUST00000086519.10 ENSMUST00000086519.11 ENSMUST00000086519.2 ENSMUST00000086519.3 ENSMUST00000086519.4 ENSMUST00000086519.5 ENSMUST00000086519.6 ENSMUST00000086519.7 ENSMUST00000086519.8 ENSMUST00000086519.9 NM_007475 Q5M8R8 Q5M8R8_MOUSE Rplp0 uc008zed.1 uc008zed.2 uc008zed.3 uc008zed.4 Ribosomal protein P0 is the functional equivalent of E.coli protein L10. Belongs to the universal ribosomal protein uL10 family. ribosome ribosome biogenesis uc008zed.1 uc008zed.2 uc008zed.3 uc008zed.4 
ENSMUST00000086521.11 Cntn2 ENSMUST00000086521.11 contactin 2 (from RefSeq NM_177129.5) CNTN2_MOUSE ENSMUST00000086521.1 ENSMUST00000086521.10 ENSMUST00000086521.2 ENSMUST00000086521.3 ENSMUST00000086521.4 ENSMUST00000086521.5 ENSMUST00000086521.6 ENSMUST00000086521.7 ENSMUST00000086521.8 ENSMUST00000086521.9 NM_177129 Q61330 Q6NZJ4 Q7TSJ5 Tax uc007cpa.1 uc007cpa.2 uc007cpa.3 This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. Mice lacking a functional copy of this gene exhibit epileptic seizures and elevated expression of A1 adenosine receptors. [provided by RefSeq, Sep 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147602.1, BC066106.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. Cell membrane ; Lipid-anchor, GPI- anchor Note=Attached to the neuronal membrane by a GPI- anchor and is also released from neurons. Belongs to the immunoglobulin superfamily. Contactin family. microtubule cytoskeleton organization neuron migration protein binding plasma membrane cell adhesion cell-matrix adhesion nervous system development axonogenesis axon guidance axonal fasciculation learning adult walking behavior cell surface regulation of cell morphogenesis involved in differentiation positive regulation of protein processing membrane cerebral cortex GABAergic interneuron migration central nervous system myelination carbohydrate binding axon regulation of axon diameter neuron projection development anchored component of membrane receptor internalization node of Ranvier neuron projection neuronal cell body myelin sheath protein self-association juxtaparanode region of axon clustering of voltage-gated potassium channels synapse negative regulation of neuron differentiation regulation of neuronal synaptic plasticity regulation of astrocyte differentiation positive regulation of adenosine receptor signaling pathway protein localization to juxtaparanode region of axon establishment of protein localization to juxtaparanode region of axon presynaptic membrane organization anchored component of postsynaptic membrane uc007cpa.1 uc007cpa.2 uc007cpa.3 
ENSMUST00000086535.12 Rpl31 ENSMUST00000086535.12 ribosomal protein L31, transcript variant 3 (from RefSeq NM_053257.4) ENSMUST00000086535.1 ENSMUST00000086535.10 ENSMUST00000086535.11 ENSMUST00000086535.2 ENSMUST00000086535.3 ENSMUST00000086535.4 ENSMUST00000086535.5 ENSMUST00000086535.6 ENSMUST00000086535.7 ENSMUST00000086535.8 ENSMUST00000086535.9 NM_053257 Q5M9K9 Q5M9K9_MOUSE Rpl31 uc007atf.1 uc007atf.2 uc007atf.3 uc007atf.4 uc007atf.5 Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL31 family. structural constituent of ribosome ribosome translation uc007atf.1 uc007atf.2 uc007atf.3 uc007atf.4 uc007atf.5 
ENSMUST00000086549.4 Gm10190 ENSMUST00000086549.4 predicted gene 10190 (from RefSeq NR_028385.2) ENSMUST00000086549.1 ENSMUST00000086549.2 ENSMUST00000086549.3 NR_028385 uc289nce.1 uc289nce.2 uc289nce.3 uc289nce.4 uc289nce.1 uc289nce.2 uc289nce.3 uc289nce.4 
ENSMUST00000086555.11 Dhx57 ENSMUST00000086555.11 DExH-box helicase 57, transcript variant 3 (from RefSeq NM_001410326.1) DHX57_MOUSE ENSMUST00000086555.1 ENSMUST00000086555.10 ENSMUST00000086555.2 ENSMUST00000086555.3 ENSMUST00000086555.4 ENSMUST00000086555.5 ENSMUST00000086555.6 ENSMUST00000086555.7 ENSMUST00000086555.8 ENSMUST00000086555.9 NM_001410326 Q3TS93 Q6NZK4 Q6P1B4 Q6P5D3 Q8BI63 Q8BIA2 Q8R360 uc008dra.1 uc008dra.2 uc008dra.3 uc008dra.4 Probable ATP-binding RNA helicase. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q6P5D3-1; Sequence=Displayed; Name=2; IsoId=Q6P5D3-2; Sequence=VSP_018063; Name=3; IsoId=Q6P5D3-3; Sequence=VSP_018065, VSP_018066; Name=4; IsoId=Q6P5D3-4; Sequence=VSP_018062, VSP_018064; Name=5; IsoId=Q6P5D3-5; Sequence=VSP_018061; Belongs to the DEAD box helicase family. DEAH subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding hydrolase activity metal ion binding uc008dra.1 uc008dra.2 uc008dra.3 uc008dra.4 
ENSMUST00000086556.12 Elk4 ENSMUST00000086556.12 ELK4, member of ETS oncogene family, transcript variant 1 (from RefSeq NM_007923.3) A6H693 ELK4_MOUSE ENSMUST00000086556.1 ENSMUST00000086556.10 ENSMUST00000086556.11 ENSMUST00000086556.2 ENSMUST00000086556.3 ENSMUST00000086556.4 ENSMUST00000086556.5 ENSMUST00000086556.6 ENSMUST00000086556.7 ENSMUST00000086556.8 ENSMUST00000086556.9 NM_007923 P41158 Sap1 uc007coc.1 uc007coc.2 uc007coc.3 Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously (By similarity). Interacts with SIRT7. Nucleus. Lung and liver. Belongs to the ETS family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter histone H3 deacetylation uc007coc.1 uc007coc.2 uc007coc.3 
ENSMUST00000086559.7 Slc41a1 ENSMUST00000086559.7 solute carrier family 41, member 1 (from RefSeq NM_173865.3) ENSMUST00000086559.1 ENSMUST00000086559.2 ENSMUST00000086559.3 ENSMUST00000086559.4 ENSMUST00000086559.5 ENSMUST00000086559.6 NM_173865 Q8BJA2 S41A1_MOUSE Slc41a1 uc007cnu.1 uc007cnu.2 uc007cnu.3 uc007cnu.4 uc007cnu.5 uc007cnu.6 Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane. Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump. Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (By similarity). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (PubMed:33153064). Reaction=Mg(2+)(in) + 2 Na(+)(out) = Mg(2+)(out) + 2 Na(+)(in); Xref=Rhea:RHEA:66616, ChEBI:CHEBI:18420, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66617; Evidence=; Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Expressed in heart, brain, kidney, liver and colon. Up-regulated in heart, brain, kidney and down-regulated in liver by low Mg(2+) diet. Phosphorylated. Belongs to the SLC41A transporter family. plasma membrane ion transport cation transport cation transmembrane transporter activity cellular magnesium ion homeostasis magnesium ion transmembrane transporter activity magnesium ion transport membrane integral component of membrane basolateral plasma membrane transmembrane transporter activity macromolecular complex sodium ion transmembrane transport magnesium:sodium antiporter activity divalent metal ion transport cellular response to magnesium ion divalent inorganic cation transmembrane transporter activity magnesium ion transmembrane transport uc007cnu.1 uc007cnu.2 uc007cnu.3 uc007cnu.4 uc007cnu.5 uc007cnu.6 
ENSMUST00000086563.11 Trmo ENSMUST00000086563.11 tRNA methyltransferase O, transcript variant 1 (from RefSeq NM_029086.2) ENSMUST00000086563.1 ENSMUST00000086563.10 ENSMUST00000086563.2 ENSMUST00000086563.3 ENSMUST00000086563.4 ENSMUST00000086563.5 ENSMUST00000086563.6 ENSMUST00000086563.7 ENSMUST00000086563.8 ENSMUST00000086563.9 NM_029086 Q3U5H3 Q562D6 Q8BRJ8 Q9D3F5 TRMO_MOUSE Trmo uc008stp.1 uc008stp.2 uc008stp.3 S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA. Reaction=N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L- methionine = H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:70027, Rhea:RHEA- COMP:10163, Rhea:RHEA-COMP:17808, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74418, ChEBI:CHEBI:188470; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70028; Evidence=; Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q562D6-1; Sequence=Displayed; Name=2; IsoId=Q562D6-2; Sequence=VSP_025816; Name=3; IsoId=Q562D6-3; Sequence=VSP_025815; [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the tRNA methyltransferase O family. RNA binding cellular_component tRNA processing methyltransferase activity tRNA (adenine-N6-)-methyltransferase activity transferase activity tRNA methylation methylation uc008stp.1 uc008stp.2 uc008stp.3 
ENSMUST00000086564.11 Git2 ENSMUST00000086564.11 GIT ArfGAP 2, transcript variant 4 (from RefSeq NM_001347400.1) E9PVA6 E9PVA6_MOUSE ENSMUST00000086564.1 ENSMUST00000086564.10 ENSMUST00000086564.2 ENSMUST00000086564.3 ENSMUST00000086564.4 ENSMUST00000086564.5 ENSMUST00000086564.6 ENSMUST00000086564.7 ENSMUST00000086564.8 ENSMUST00000086564.9 Git2 NM_001347400 uc057lnm.1 uc057lnm.2 uc057lnm.3 GTPase activator activity nucleoplasm positive regulation of GTPase activity metal ion binding uc057lnm.1 uc057lnm.2 uc057lnm.3 
ENSMUST00000086580.12 Yap1 ENSMUST00000086580.12 yes-associated protein 1, transcript variant 2 (from RefSeq NM_009534.3) ENSMUST00000086580.1 ENSMUST00000086580.10 ENSMUST00000086580.11 ENSMUST00000086580.2 ENSMUST00000086580.3 ENSMUST00000086580.4 ENSMUST00000086580.5 ENSMUST00000086580.6 ENSMUST00000086580.7 ENSMUST00000086580.8 ENSMUST00000086580.9 NM_009534 P46938 Q52KJ5 Q91WL1 YAP1_MOUSE Yap Yap65 uc009ode.1 uc009ode.2 uc009ode.3 uc009ode.4 uc009ode.5 This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress apoptosis. This protein may be involved in malignant transformation in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:29400695). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization. Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity). In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:21145499). Binds to the SH3 domain of the YES kinase (By similarity). Binds to WBP1 and WBP2 (PubMed:7644498). Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (PubMed:9407065). The phosphorylated form interacts with YWHAB (By similarity). Interacts (via WW domains) with LATS1 (via PPxY motif 2) (By similarity). Interacts with LATS2 (By similarity). Interacts (via WW domain 1) with isoform JM-A of ERBB4 (via PPxY motif 2) (By similarity). Interacts with TEAD1, TEAD2 and TEAD3 (By similarity). Interacts with TP73 and HCK (By similarity). Interacts with RUNX1 (By similarity). Interacts with TEAD4 (PubMed:20123908). Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional co- activator activity (By similarity). Interacts (when phosphorylated at Ser-112) with SMAD2, SMAD3 and WWTR1 (PubMed:21145499). Interacts with PRRG2 (via cytoplasmic domain) (By similarity). Interacts (via WW domains) with PRRG4 (via cytoplasmic domain) (By similarity). Interacts (phosphorylated) with CLDN18; the interaction sequesters YAP1 away from the nucleus and thereby restricts transcription of YAP1 target genes (PubMed:29400695). Interacts with SMAD1 (By similarity). P46938; Q501J6: Ddx17; NbExp=3; IntAct=EBI-1211949, EBI-911206; P46938; P97474: Pitx2; NbExp=2; IntAct=EBI-1211949, EBI-1175125; P46938; P30051: Tead1; NbExp=4; IntAct=EBI-1211949, EBI-3953905; P46938; Q9JJP2: Tp73; NbExp=2; IntAct=EBI-1211949, EBI-1770138; Cytoplasm Nucleus ll junction Note=Both phosphorylation and cell density can regulate its subcellular localization (By similarity). Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (By similarity). At low density, predominantly nuclear and is translocated to the cytoplasm at high density. PTPN14 induces translocation from the nucleus to the cytoplasm (By similarity). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (PubMed:21145499). Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms lacking the transactivation domain exist.; Name=1; Synonyms=YAP2L; IsoId=P46938-1; Sequence=Displayed; Name=2; Synonyms=YAP2; IsoId=P46938-2; Sequence=VSP_039056; Isoforms lacking the transactivation domain seen in striatal neurons (at protein level). Ubiquitous. Isoform 2 is expressed at higher levels in the neural tissues. In the embryo, it is expressed in brain, eye, and the maxillary and frontonasal components of the primary palate. The first coiled-coil region mediates most of the interaction with TEAD transcription factors. Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation. Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage. Phosphorylation at Ser- 385 and Ser-388 by CK1 is triggered by previous phosphorylation at Ser- 382 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation (By similarity). Phosphorylated at Thr-104, Ser-123, Ser-352 and Thr-397 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regulation of apoptosis by YAP1 (By similarity). Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase. Belongs to the YAP1 family. cell morphogenesis RNA polymerase II core promoter proximal region sequence-specific DNA binding vasculogenesis tissue homeostasis heart process embryonic heart tube morphogenesis chromatin binding transcription coactivator activity transcription corepressor activity protein binding nucleus transcription factor complex cytoplasm cytosol cellular response to DNA damage stimulus DNA damage induced protein phosphorylation protein C-terminus binding transcription factor binding cell proliferation positive regulation of cell proliferation regulation of gene expression regulation of keratinocyte proliferation membrane keratinocyte differentiation negative regulation of epithelial cell differentiation notochord development response to progesterone positive regulation of intracellular estrogen receptor signaling pathway activating transcription factor binding somatic stem cell population maintenance hippo signaling regulation of cell proliferation transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of organ growth protein heterodimerization activity paraxial mesoderm development lateral mesoderm development regulation of neurogenesis progesterone receptor signaling pathway positive regulation of cardiac muscle cell proliferation contact inhibition bud elongation involved in lung branching lung epithelial cell differentiation regulation of canonical Wnt signaling pathway cardiac muscle tissue regeneration macromolecular complex assembly proline-rich region binding TEAD-1-YAP complex TEAD-2-YAP complex cellular response to retinoic acid cellular response to gamma radiation regulation of stem cell proliferation regulation of metanephric nephron tubule epithelial cell differentiation positive regulation of canonical Wnt signaling pathway positive regulation of stem cell population maintenance negative regulation of nucleic acid-templated transcription negative regulation of stem cell differentiation negative regulation of extrinsic apoptotic signaling pathway uc009ode.1 uc009ode.2 uc009ode.3 uc009ode.4 uc009ode.5 
ENSMUST00000086615.3 Lhfpl7 ENSMUST00000086615.3 LHFPL tetraspan subfamily member 7 (from RefSeq NM_001033428.2) B9EJN6 ENSMUST00000086615.1 ENSMUST00000086615.2 Gm854 LHPL7_MOUSE NM_001033428 Q3UUA0 Tmem211 uc008yub.1 uc008yub.2 Membrane ; Multi-pass membrane protein Belongs to the TMEM211 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008yub.1 uc008yub.2 
ENSMUST00000086617.11 Myo18b ENSMUST00000086617.11 myosin XVIIIb (from RefSeq NM_028901.2) E9PV66 E9PV66_MOUSE ENSMUST00000086617.1 ENSMUST00000086617.10 ENSMUST00000086617.2 ENSMUST00000086617.3 ENSMUST00000086617.4 ENSMUST00000086617.5 ENSMUST00000086617.6 ENSMUST00000086617.7 ENSMUST00000086617.8 ENSMUST00000086617.9 Myo18b NM_028901 uc008ytr.1 uc008ytr.2 uc008ytr.3 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Lacks conserved residue(s) required for the propagation of feature annotation. nucleotide binding vasculogenesis in utero embryonic development molecular_function motor activity actin binding ATP binding myosin complex unconventional myosin complex Z disc filamentous actin cardiac muscle fiber development uc008ytr.1 uc008ytr.2 uc008ytr.3 
ENSMUST00000086639.6 Alk ENSMUST00000086639.6 anaplastic lymphoma kinase (from RefSeq NM_007439.2) ALK_MOUSE Alk E9QKV3 ENSMUST00000086639.1 ENSMUST00000086639.2 ENSMUST00000086639.3 ENSMUST00000086639.4 ENSMUST00000086639.5 NM_007439 P97793 uc008dnb.1 uc008dnb.2 uc008dnb.3 Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:15226403, PubMed:16458083, PubMed:16878150, PubMed:19200234, PubMed:30497772). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (PubMed:32442405). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response. In contrast, ALKAL1 is not a potent physiological ligand for ALK. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x- Y-Y motif. Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK). PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence= Activated upon ALKAL2 ligand-binding. ALKAL2- driven activation is coupled with heparin-binding (By similarity). Following ligand-binding, homodimerizes and autophosphorylates, activating its kinase activity (By similarity). Inactivated through dephosphorylation by receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) when there is no stimulation by a ligand (By similarity). Homodimer; homodimerizes following heparin- and ligand-binding (By similarity). Interacts with CBL, IRS1, PIK3R1 and PLCG1 (PubMed:15226403, PubMed:16878150). Interacts with FRS2 and SHC1 (PubMed:15226403, PubMed:16878150). Interacts with PTN and MDK (By similarity). Cell membrane ; Single-pass type I membrane protein Note=Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. Mainly expressed in central nervous system (CNS) and other parts of the brain such as the paraventricular nucleus (PVN) of the hypothalamus. Expression is also found in peripheral nervous systems, eye, nasal epithelium, olfactory nerve, tongue, skin, tissue surrounding the esophagus, stomach, midgut, as well as testis and ovary. In the hypothalamus, expression is induced in response to feeding. The EGF-like region drives the cytokine specificity for ALKAL2. The heparin-binding region binds heparin glycosaminoglycan. Heparin-binding is required for ALKAL2-driven activation. Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation. Mice display a decrease in newborn neurons and defects in brain function (PubMed:17487225, PubMed:22079349). Mice show an age-dependent increase in basal hippocampal progenitor proliferation and alterations in behavioral tests (PubMed:17487225). Mice lacking both Alk and Ltk show a strong reduction in newborn neurons (PubMed:22079349). Mutants develop a thin phenotype at the age of 5 weeks, persisting into adulthood with reduced body adiposity, elevated adiponectin levels and improved glucose homeostasis, while having unaltered food intake and activity (PubMed:32442405). They show a marked resistance to diet- and leptin-mutation-induced obesity and exhibit increased adipose tissue lipolysis (PubMed:32442405). Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. nucleotide binding activation of MAPK activity protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding plasma membrane integral component of plasma membrane protein phosphorylation signal transduction transmembrane receptor protein tyrosine kinase signaling pathway nervous system development brain development membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation hippocampus development axon adult behavior macromolecular complex swimming behavior regulation of cell proliferation identical protein binding receptor complex cell body regulation of neuron differentiation protein autophosphorylation neuron development regulation of dopamine receptor signaling pathway response to environmental enrichment positive regulation of dendrite development uc008dnb.1 uc008dnb.2 uc008dnb.3 
ENSMUST00000086687.10 Plcxd1 ENSMUST00000086687.10 phosphatidylinositol-specific phospholipase C, X domain containing 1, transcript variant 1 (from RefSeq NM_207279.3) ENSMUST00000086687.1 ENSMUST00000086687.2 ENSMUST00000086687.3 ENSMUST00000086687.4 ENSMUST00000086687.5 ENSMUST00000086687.6 ENSMUST00000086687.7 ENSMUST00000086687.8 ENSMUST00000086687.9 G3X9J3 G3X9J3_MOUSE NM_207279 Plcxd1 uc008ypo.1 uc008ypo.2 uc008ypo.3 uc008ypo.4 uc008ypo.5 lipid metabolic process phosphoric diester hydrolase activity uc008ypo.1 uc008ypo.2 uc008ypo.3 uc008ypo.4 uc008ypo.5 
ENSMUST00000086690.6 Serpinb7 ENSMUST00000086690.6 serine (or cysteine) peptidase inhibitor, clade B, member 7 (from RefSeq NM_027548.4) ENSMUST00000086690.1 ENSMUST00000086690.2 ENSMUST00000086690.3 ENSMUST00000086690.4 ENSMUST00000086690.5 NM_027548 Q9D695 SPB7_MOUSE uc007chm.1 uc007chm.2 uc007chm.3 Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin (By similarity). Cytoplasm Belongs to the serpin family. Ov-serpin subfamily. serine-type endopeptidase inhibitor activity extracellular space cytoplasm negative regulation of peptidase activity negative regulation of endopeptidase activity regulation of proteolysis peptidase inhibitor activity positive regulation of transforming growth factor beta1 production positive regulation of collagen biosynthetic process positive regulation of glomerular mesangial cell proliferation positive regulation of platelet-derived growth factor production uc007chm.1 uc007chm.2 uc007chm.3 
ENSMUST00000086693.12 Mtcl1 ENSMUST00000086693.12 microtubule crosslinking factor 1, transcript variant 2 (from RefSeq NM_172963.4) Ccdc165 ENSMUST00000086693.1 ENSMUST00000086693.10 ENSMUST00000086693.11 ENSMUST00000086693.2 ENSMUST00000086693.3 ENSMUST00000086693.4 ENSMUST00000086693.5 ENSMUST00000086693.6 ENSMUST00000086693.7 ENSMUST00000086693.8 ENSMUST00000086693.9 Kiaa0802 MTCL1_MOUSE NM_172963 Q3UHU5 Q6PAM2 Q80TR7 Soga2 uc008djw.1 uc008djw.2 uc008djw.3 Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (By similarity). [Isoform 1]: Homodimer. Interacts with MARK2; the interaction increases MARK2 microtubule-binding ability. Associates (via N- and C- terminus domains) with microtubule filaments. [Isoform 1]: Lateral cell membrane Apical cell membrane Cytoplasm, cytoskeleton, spindle pole Midbody Cytoplasm, cytoskeleton Note=Colocalized with microtubules at the base of cilia. Gradually accumulates on the apicobasal microtubule bundles during epithelial cell polarization (By similarity). Colocalized with the apicobasal microtubule bundles running beneath the lateral membrane. Colocalized with microtubule bundles in the spindle pole in mitotic cells and in the midbodies at the end of cytokinesis. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UHU5-1; Sequence=Displayed; Name=2; IsoId=Q3UHU5-2; Sequence=VSP_023555; Name=3; IsoId=Q3UHU5-3; Sequence=VSP_023556; Belongs to the SOGA family. spindle pole microtubule bundle formation protein binding extracellular space cytoplasm cytoskeleton plasma membrane microtubule binding regulation of autophagy membrane apical plasma membrane apicolateral plasma membrane lateral plasma membrane midbody protein homodimerization activity establishment or maintenance of epithelial cell apical/basal polarity positive regulation of protein targeting to membrane microtubule bundle positive regulation of microtubule motor activity uc008djw.1 uc008djw.2 uc008djw.3 
ENSMUST00000086701.13 Serpinb5 ENSMUST00000086701.13 serine (or cysteine) peptidase inhibitor, clade B, member 5, transcript variant 2 (from RefSeq NM_009257.4) ENSMUST00000086701.1 ENSMUST00000086701.10 ENSMUST00000086701.11 ENSMUST00000086701.12 ENSMUST00000086701.2 ENSMUST00000086701.3 ENSMUST00000086701.4 ENSMUST00000086701.5 ENSMUST00000086701.6 ENSMUST00000086701.7 ENSMUST00000086701.8 ENSMUST00000086701.9 NM_009257 P70124 Pi5 Q3ULZ0 SPB5_MOUSE Spi5 Spi7 uc007cha.1 uc007cha.2 uc007cha.3 Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity). Interacts with IRF6. Secreted, extracellular space. Belongs to the serpin family. Ov-serpin subfamily. morphogenesis of an epithelium serine-type endopeptidase inhibitor activity extracellular region extracellular space cytoplasm negative regulation of endopeptidase activity extracellular matrix organization regulation of epithelial cell proliferation prostate gland morphogenesis uc007cha.1 uc007cha.2 uc007cha.3 
ENSMUST00000086722.10 Tmem232 ENSMUST00000086722.10 transmembrane protein 232, transcript variant 3 (from RefSeq NM_001008973.2) B2RX35 B7ZWG2 ENSMUST00000086722.1 ENSMUST00000086722.2 ENSMUST00000086722.3 ENSMUST00000086722.4 ENSMUST00000086722.5 ENSMUST00000086722.6 ENSMUST00000086722.7 ENSMUST00000086722.8 ENSMUST00000086722.9 NM_001008973 Q5K6N0 Q5K6N1 TM232_MOUSE Tes13 uc008dgb.1 uc008dgb.2 Plays a critical role for male fertility and sperm motility by regulating sperm cytoplasm removal and maintaining axoneme integrity. Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Tes13-L; IsoId=Q5K6N0-1; Sequence=Displayed; Name=2; Synonyms=Tes13-S; IsoId=Q5K6N0-2; Sequence=VSP_039353; Name=3; IsoId=Q5K6N0-3; Sequence=VSP_039354; High expression in the testis and weak expression levels in the spleen, liver, brain, uterus, lung, epididymis and kidney. Not detected in the heart or ovary. Deficient mice are viable and display no apparent abnormalities. However male mice are infertile. Mice display an abnormal sperm flagellum morphology. Furthermore, mice have low sperm motility and decreased total sperm count. The sperm flagella of deficient mice have abnormalities in the cytoplasm removal and the flagella axoneme lacks microtubule doublet 7 and the corresponding ODF. molecular_function cellular_component biological_process membrane integral component of membrane uc008dgb.1 uc008dgb.2 
ENSMUST00000086723.10 Man2a1 ENSMUST00000086723.10 mannosidase 2, alpha 1 (from RefSeq NM_008549.2) B9EHS6 ENSMUST00000086723.1 ENSMUST00000086723.2 ENSMUST00000086723.3 ENSMUST00000086723.4 ENSMUST00000086723.5 ENSMUST00000086723.6 ENSMUST00000086723.7 ENSMUST00000086723.8 ENSMUST00000086723.9 MA2A1_MOUSE Mana2 NM_008549 P27046 uc008dfy.1 uc008dfy.2 uc008dfy.3 Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway. Reaction=2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha- D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man- (1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man- (1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc}-L-asparaginyl-[protein]; Xref=Rhea:RHEA:56052, Rhea:RHEA-COMP:14368, Rhea:RHEA-COMP:14369, ChEBI:CHEBI:15377, ChEBI:CHEBI:28729, ChEBI:CHEBI:60615, ChEBI:CHEBI:60625; EC=3.2.1.114; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Protein modification; protein glycosylation. Homodimer; disulfide-linked. Golgi apparatus membrane; Single-pass type II membrane protein. All tissues, mostly in adrenal and thymus. Glycosylated. Belongs to the glycosyl hydrolase 38 family. Golgi membrane in utero embryonic development liver development catalytic activity alpha-mannosidase activity mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity extracellular space Golgi apparatus Golgi medial cisterna cis-Golgi network carbohydrate metabolic process mannose metabolic process protein glycosylation N-glycan processing protein deglycosylation mitochondrion organization vacuole organization respiratory gaseous exchange metabolic process mannosidase activity membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing N-glycosyl compounds carbohydrate binding metal ion binding lung alveolus development positive regulation of neurogenesis retina morphogenesis in camera-type eye uc008dfy.1 uc008dfy.2 uc008dfy.3 
ENSMUST00000086738.10 Cntnap5b ENSMUST00000086738.10 contactin associated protein-like 5B (from RefSeq NM_172851.3) CTP5B_MOUSE Caspr5-2 ENSMUST00000086738.1 ENSMUST00000086738.2 ENSMUST00000086738.3 ENSMUST00000086738.4 ENSMUST00000086738.5 ENSMUST00000086738.6 ENSMUST00000086738.7 ENSMUST00000086738.8 ENSMUST00000086738.9 NM_172851 Q0V8T8 Q2PAX9 Q8BUT8 uc007cfy.1 uc007cfy.2 uc007cfy.3 May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0V8T8-1; Sequence=Displayed; Name=2; IsoId=Q0V8T8-2; Sequence=VSP_030943; Expressed in brain. Expressed from 6 dpc in brain. Belongs to the neurexin family. Sequence=BAC38563.1; Type=Frameshift; Evidence=; cell adhesion membrane integral component of membrane uc007cfy.1 uc007cfy.2 uc007cfy.3 
ENSMUST00000086763.13 Adgre1 ENSMUST00000086763.13 adhesion G protein-coupled receptor E1, transcript variant 1 (from RefSeq NM_010130.5) AGRE1_MOUSE ENSMUST00000086763.1 ENSMUST00000086763.10 ENSMUST00000086763.11 ENSMUST00000086763.12 ENSMUST00000086763.2 ENSMUST00000086763.3 ENSMUST00000086763.4 ENSMUST00000086763.5 ENSMUST00000086763.6 ENSMUST00000086763.7 ENSMUST00000086763.8 ENSMUST00000086763.9 Emr1 Gpf480 NM_010130 Q61549 uc008deu.1 uc008deu.2 uc008deu.3 uc008deu.4 Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development. Cell membrane ; Multi-pass membrane protein In macrophages; but absent from those which are localized within T-cell areas of lymph nodes and spleen. Low level of expression on blood monocytes. Deficient mice fail to develop peripheral tolerance after inoculation with antigen because of a lack of efferent regulatory T-cell development. Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. adaptive immune response immune system process transmembrane signaling receptor activity G-protein coupled receptor activity calcium ion binding plasma membrane integral component of plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway external side of plasma membrane membrane integral component of membrane cell periphery uc008deu.1 uc008deu.2 uc008deu.3 uc008deu.4 
ENSMUST00000086787.11 Tcp10b ENSMUST00000086787.11 t-complex protein 10b (from RefSeq NM_009341.2) E9PYJ0 E9PYJ0_MOUSE ENSMUST00000086787.1 ENSMUST00000086787.10 ENSMUST00000086787.2 ENSMUST00000086787.3 ENSMUST00000086787.4 ENSMUST00000086787.5 ENSMUST00000086787.6 ENSMUST00000086787.7 ENSMUST00000086787.8 ENSMUST00000086787.9 F6SKG2 NM_009341 Tcp10b uc008aly.1 uc008aly.2 uc008aly.3 Belongs to the TCP10 family. transcription corepressor activity nucleus centriole negative regulation of nucleic acid-templated transcription uc008aly.1 uc008aly.2 uc008aly.3 
ENSMUST00000086795.8 Barhl2 ENSMUST00000086795.8 BarH like homeobox 2 (from RefSeq NM_001005477.1) BARH2_MOUSE Barh1 ENSMUST00000086795.1 ENSMUST00000086795.2 ENSMUST00000086795.3 ENSMUST00000086795.4 ENSMUST00000086795.5 ENSMUST00000086795.6 ENSMUST00000086795.7 Mbh1 NM_001005477 Q66L43 Q8VIB5 uc008ylm.1 uc008ylm.2 Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up- regulate NGN2, thereby regulating distinct patterns of neuronal differentiation (By similarity). Nucleus Belongs to the BAR homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cell fate determination neuron migration DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development nervous system development tissue development neuron differentiation regulation of axon extension sequence-specific DNA binding cell fate commitment positive regulation of translation positive regulation of transcription from RNA polymerase II promoter animal organ development uc008ylm.1 uc008ylm.2 
ENSMUST00000086829.11 Bicd1 ENSMUST00000086829.11 BICD cargo adaptor 1, transcript variant 2 (from RefSeq NM_009753.4) BICD1_MOUSE ENSMUST00000086829.1 ENSMUST00000086829.10 ENSMUST00000086829.2 ENSMUST00000086829.3 ENSMUST00000086829.4 ENSMUST00000086829.5 ENSMUST00000086829.6 ENSMUST00000086829.7 ENSMUST00000086829.8 ENSMUST00000086829.9 NM_009753 O55206 Q8BQ18 Q8BR07 Q8BRR8 Q8C4D3 Q8CAK6 Q8R2J4 Q8R2J5 Q8R2J6 Q91YP7 uc009euh.1 uc009euh.2 uc009euh.3 uc009euh.4 uc009euh.5 Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. Interacts with RAB6A. Interacts (via C-terminus) with RAB6B (GTP-bound); the interaction is direct (By similarity). Interacts with CLIP-115 and KIFC2. Q8BR07; Q6PB44: Ptpn23; NbExp=7; IntAct=EBI-11569902, EBI-4284816; Golgi apparatus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BR07-1; Sequence=Displayed; Name=2; IsoId=Q8BR07-2; Sequence=VSP_007965, VSP_007966; Name=3; IsoId=Q8BR07-3; Sequence=VSP_007967; Name=4; IsoId=Q8BR07-4; Sequence=VSP_007968; Expressed in the brain, heart and skeletal muscle. Expressed during embryonic development. [Isoform 2]: Due to intron retention. [Isoform 4]: Due to intron retention. Belongs to the BicD family. Golgi apparatus trans-Golgi network centrosome cytosol cytoskeletal adaptor activity membrane viral process Rab GTPase binding protein kinase binding cytoplasmic vesicle proteinase activated receptor binding protein localization to organelle stress granule assembly dynactin binding dynein intermediate chain binding positive regulation of receptor-mediated endocytosis perinuclear region of cytoplasm regulation of microtubule cytoskeleton organization dynein complex binding minus-end-directed organelle transport along microtubule microtubule anchoring at microtubule organizing center host cell viral assembly compartment negative regulation of phospholipase C activity regulation of proteinase activated receptor activity negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of protein localization to centrosome cytoplasmic microtubule uc009euh.1 uc009euh.2 uc009euh.3 uc009euh.4 uc009euh.5 
ENSMUST00000086831.4 Pkd2 ENSMUST00000086831.4 polycystin 2, transient receptor potential cation channel (from RefSeq NM_008861.3) C0KJK2 E9Q4F6 E9QQA3 ENSMUST00000086831.1 ENSMUST00000086831.2 ENSMUST00000086831.3 NM_008861 O35245 PKD2_MOUSE Pkd2 Q8BPR6 Q9ES37 Q9QWP0 Q9Z193 Q9Z194 TRPP2 uc012eab.1 uc012eab.2 uc012eab.3 Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (PubMed:27214281). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735, PubMed:18695040, PubMed:27760766, PubMed:31048699). Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:27760766). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By similarity). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells (PubMed:9568711, PubMed:10615132). Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (PubMed:20096584). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (PubMed:21307093, PubMed:22983710). Detection of asymmetric nodal flow gives rise to a Ca(2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (PubMed:12062060, PubMed:21307093, PubMed:22983710). Channel activity is regulated by phosphorylation (By similarity). The channel is activated by increased cytoplasmic Ca(2+) (in the uM range) and by membrane depolarization (PubMed:27760766). Component of the heterotetrameric polycystin channel complex with PKD1; the tetramer contains one PKD1 chain and three PKD2 chains (By similarity). Interaction with PKD1 is required for ciliary localization (PubMed:25405894). Homotetramer (By similarity). Isoform 1 interacts with PKD1 while isoform 3 does not (PubMed:16192288). Interacts with PKD1L1 (PubMed:21307093, PubMed:22983710). PKD1 requires the presence of PKD2 for stable expression (PubMed:16192288). Interacts with CD2AP (PubMed:10913159). Interacts with HAX1 (PubMed:10760273). Interacts with NEK8 (PubMed:18235101). Part of a complex containing AKAP5, ADCY5, ADCY6 and PDE4C (PubMed:21670265). Interacts (via C- terminus) with TRPV4 (via C-terminus) (PubMed:18695040). Interacts (via C-terminal acidic region) with PACS1 and PACS2; these interactions retain the protein in the endoplasmic reticulum and prevent trafficking to the cell membrane (PubMed:15692563). Interacts with TMEM33 (PubMed:31048699). O35245; E2JF22: Piezo1; NbExp=3; IntAct=EBI-9823400, EBI-9837938; Cell projection, cilium membrane ulti-pass membrane protein Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane doplasmic reticulum membrane lgi apparatus Vesicle Secreted, extracellular exosome Note=PKD2 localization to the plasma and ciliary membranes requires PKD1. PKD1:PKD2 interaction is required to reach the Golgi apparatus form endoplasmic reticulum and then traffic to the cilia (PubMed:25405894). Detected on kidney tubule basolateral membranes and basal cytoplasmic vesicles (PubMed:9568711, PubMed:10770959). Retained in the endoplasmic reticulum by interaction with PACS1 and PACS2. Cilium localization requires GANAB (By similarity). Detected on migrasomes and on extracellular exosomes in urine (By similarity). Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=O35245-1; Sequence=Displayed; Name=2; Synonyms=delta6; IsoId=O35245-2; Sequence=VSP_042485, VSP_042486; Name=3; Synonyms=delta7; IsoId=O35245-3; Sequence=VSP_042487; Name=4; Synonyms=delta9; IsoId=O35245-4; Sequence=VSP_042488, VSP_042489; Name=5; Synonyms=delta12/13; IsoId=O35245-5; Sequence=VSP_042490; Detected in kidney epithelium (at protein level) (PubMed:9568711, PubMed:10770959, PubMed:11854751). Highly expressed on basolateral membranes in distal convoluted tubules and medullary thick ascending limbs of Henle (PubMed:9568711). Detected at much lower levels in cortical and medullary collecting tubules, and not detected in the glomerular tuft, in thin limbs of Henle, interstitium and blood vessels (at protein level) (PubMed:9568711). Expressed in mesenchymally derived structures in the developing embryo at day 12.5. Isoform 1 is predominantly expressed in kidney at all developmental stages with high levels also detected in lung. Isoform 3 shows highest expression in brain with lower expression in kidney and lung, low levels in thymus and is hardly detectable in liver. Ubiquitous in embryos at the early somite stage. The C-terminal coiled-coil domain is involved in oligomerization and the interaction with PKD1. The isolated coiled-coil domain forms a homotrimer in vitro; the homotrimer interacts with a single PKD1 chain. The coiled-coil domain binds calcium and undergoes a calcium-induced conformation change (in vitro). N-glycosylated (PubMed:11854751). The four subunits in a tetramer probably differ in the extent of glycosylation; simultaneous glycosylation of all experimentally validated sites would probably create steric hindrance (By similarity). Phosphorylated (PubMed:16551655). Phosphorylation is important for protein function; a mutant that lacks the N-terminal phosphorylation sites cannot complement a zebrafish pkd2-deficient mutant. PKD-mediated phosphorylation at the C-terminus regulates its function in the release of Ca(2+) stores from the endoplasmic reticulum. PKA-mediated phosphorylation at a C-terminal site strongly increases the open probability of the channel, but does not increase single channel conductance. Complete embryonic lethality, with most embryos surviving up to about 16.5 dpc (PubMed:9568711, PubMed:10615132, PubMed:12062060). Embryos lacking Pkd2 develop normally up to 13.5 dpc, but after that about half of them display total body edema and focal hemorrhages (PubMed:10615132). Mutant embryos display defects in left- right laterality, including abnormal heart looping (PubMed:12062060). After 13.5 dpc, all embryos display defects in heart development, with defective formation of the interventricular septum (PubMed:10615132, PubMed:12062060). Besides, many display defective formation of the atrial septum and pericardial effusions (PubMed:10615132). After 14.5 dpc, the embryos display progressive cystic dilatation of pancreatic ducts (PubMed:10615132). After 15.5 dpc, they display progressive kidney cyst formation (PubMed:10615132). In contrast, liver development is normal, without any cyst formation (PubMed:10615132). Heterozygous mice with one null allele and one instable allele that leads to somatic loss of Pkd2 expression due to intragenic recombination all display bilateral renal cysts at an age of about 11 weeks (PubMed:9568711). These cysts cover 25-75% of the cut surface area of each kidney (PubMed:9568711). Progressive cyst formation leads eventually to renal failure and shortened lifespan (PubMed:10615132). Besides, these mice all display liver cysts and half of them display also bile duct proliferation (PubMed:9568711). About half of the heterozygous mice with one null allele and one instable allele that leads to somatic loss of Pkd2 expression due to intragenic recombination display visible pancreas cysts at an age of three months (PubMed:10615132). Mice homozygous for an instable allele that leads to somatic loss of Pkd2 expression due to intragenic recombination develop renal cysts that arise from cells that have lost Pkd2 expression (PubMed:9568711). Heterozygous mice that bear one null allele also have a reduced lifespan, but this is not due to kidney failure (PubMed:10615132). [Isoform 5]: Minor isoform. Belongs to the polycystin family. branching involved in ureteric bud morphogenesis kidney development liver development embryonic placenta development heart looping polycystin complex detection of nodal flow receptor binding voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated sodium channel activity voltage-gated potassium channel activity cation channel activity calcium channel activity potassium channel activity calcium ion binding protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane integral component of plasma membrane cilium ion transport potassium ion transport calcium ion transport cellular calcium ion homeostasis cell cycle arrest positive regulation of cytosolic calcium ion concentration JAK-STAT cascade determination of left/right symmetry heart development cytoskeletal protein binding basal plasma membrane positive regulation of gene expression channel activity outward rectifier potassium channel activity membrane integral component of membrane Wnt signaling pathway basolateral plasma membrane spinal cord development neural tube development voltage-gated cation channel activity lamellipodium cytoplasmic vesicle membrane cytoplasmic vesicle motile cilium positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity filamentous actin cation channel complex regulation of ion transmembrane transport metanephric part of ureteric bud development sodium ion transmembrane transport aorta development ciliary basal body regulation of cell proliferation identical protein binding protein homodimerization activity actinin binding cytoplasmic sequestering of transcription factor cell projection HLH domain binding ion channel binding cilium organization basal cortex positive regulation of nitric oxide biosynthetic process positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription from RNA polymerase II promoter metal ion binding calcium-induced calcium release activity detection of mechanical stimulus ATPase binding release of sequestered calcium ion into cytosol phosphoprotein binding protein tetramerization protein homotetramerization protein heterotetramerization muscle alpha-actinin binding alpha-actinin binding ciliary membrane negative regulation of ryanodine-sensitive calcium-release channel activity placenta blood vessel development renal tubule morphogenesis renal artery morphogenesis calcium ion transmembrane transport positive regulation of cell cycle arrest cellular response to calcium ion cellular response to cAMP integral component of cytoplasmic side of endoplasmic reticulum membrane cellular response to hydrostatic pressure cellular response to osmotic stress cellular response to fluid shear stress integral component of lumenal side of endoplasmic reticulum membrane potassium ion transmembrane transport determination of liver left/right asymmetry metanephric mesenchyme development mesonephric tubule development mesonephric duct development metanephric smooth muscle tissue development metanephric cortex development metanephric ascending thin limb development metanephric cortical collecting duct development metanephric distal tubule development metanephric S-shaped body morphogenesis mitotic spindle regulation of calcium ion import non-motile cilium inorganic cation transmembrane transport cell-cell signaling by wnt negative regulation of G1/S transition of mitotic cell cycle cell-cell junction uc012eab.1 uc012eab.2 uc012eab.3 
ENSMUST00000086843.11 Asb1 ENSMUST00000086843.11 ankyrin repeat and SOCS box-containing 1, transcript variant 1 (from RefSeq NM_001039126.2) ASB1_MOUSE ENSMUST00000086843.1 ENSMUST00000086843.10 ENSMUST00000086843.2 ENSMUST00000086843.3 ENSMUST00000086843.4 ENSMUST00000086843.5 ENSMUST00000086843.6 ENSMUST00000086843.7 ENSMUST00000086843.8 ENSMUST00000086843.9 NM_001039126 Q9WV74 uc007caz.1 uc007caz.2 uc007caz.3 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Mediates Notch-induced ubiquitination and degradation of TCF3/E2A and JAK2 (By similarity). May play a role in testis development (PubMed:11509662). Protein modification; protein ubiquitination. Interacts with CUL5 and RNF7. Highest expression in testis, spleen, bone marrow and salivary gland. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Decreased spermatogenesis with less complete filling of seminiferous tubules but fertility does not appear to be affected. Belongs to the ankyrin SOCS box (ASB) family. ubiquitin ligase complex multicellular organism development protein ubiquitination male genitalia development intracellular signal transduction ubiquitin protein ligase activity uc007caz.1 uc007caz.2 uc007caz.3 
ENSMUST00000086851.2 Hes6 ENSMUST00000086851.2 hairy and enhancer of split 6, transcript variant 1 (from RefSeq NM_019479.3) ENSMUST00000086851.1 HES6_MOUSE Hes6 NM_019479 Q3U2D7 Q9JHE6 uc007cau.1 uc007cau.2 Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up- regulate transcription in its presence. Promotes cell differentiation. Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family (By similarity). Interacts with HES1. Nucleus Expressed in both undifferentiated and differentiated cells. High levels of expression are observed in several embryonic tissues including the nervous system, muscle and thymus. In the nervous system, initially expressed in the closing neural tube, then in the spinal cord, cranial and dorsal root ganglia, and brain neuroepithelium. Also expressed in epithelial cells of the embryonic respiratory, urinary and digestive systems. In the limb buds, expressed in skeletal muscle and presumptive tendons. Expressed in both embryo and adult. Expression in the embryo is detected from 8.5 dpc. In the retina, expressed at high levels at postnatal 0 dpc. Expression in brain and retina decreases postnatally but still detectable in adult. The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy- related proteins. Has a particular type of basic domain (presence of a helix- interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG). negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription cofactor activity nucleus transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development nervous system development transcription factor binding anterior/posterior pattern specification cell differentiation protein homodimerization activity protein heterodimerization activity protein dimerization activity regulation of neurogenesis uc007cau.1 uc007cau.2 
ENSMUST00000086854.10 Mapk10 ENSMUST00000086854.10 mitogen-activated protein kinase 10, transcript variant 22 (from RefSeq NM_001407599.1) ENSMUST00000086854.1 ENSMUST00000086854.2 ENSMUST00000086854.3 ENSMUST00000086854.4 ENSMUST00000086854.5 ENSMUST00000086854.6 ENSMUST00000086854.7 ENSMUST00000086854.8 ENSMUST00000086854.9 JNK3B2 Mapk10 NM_001407599 Q80W80 Q80W80_MOUSE uc008yjc.1 uc008yjc.2 uc008yjc.3 uc008yjc.4 uc008yjc.5 Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. MAPK cascade nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity ATP binding protein phosphorylation kinase activity phosphorylation transferase activity uc008yjc.1 uc008yjc.2 uc008yjc.3 uc008yjc.4 uc008yjc.5 
ENSMUST00000086861.12 Erfe ENSMUST00000086861.12 erythroferrone (from RefSeq NM_173395.2) C1qtnf15 Ctrp15 E3VWA0 ENSMUST00000086861.1 ENSMUST00000086861.10 ENSMUST00000086861.11 ENSMUST00000086861.2 ENSMUST00000086861.3 ENSMUST00000086861.4 ENSMUST00000086861.5 ENSMUST00000086861.6 ENSMUST00000086861.7 ENSMUST00000086861.8 ENSMUST00000086861.9 ERFE_MOUSE Erfe Fam132b NM_173395 Q6PGN1 Q8CE11 uc007caj.1 uc007caj.2 Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores (PubMed:24880340, PubMed:30097509, PubMed:31800957, PubMed:34002695). Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (PubMed:22351773). Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling (PubMed:30566056). Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway (PubMed:24187137). Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling (PubMed:34002695). The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption (PubMed:34002695). Homodimer; disulfide-linked (PubMed:22351773). Forms trimer, hexamers and higher molecular weight oligomers (PubMed:32602701). May form heteromeric complexes with C1QTNF2 and C1QTNF12 and, to a lesser extent, with C1QTNF5 and C1QTNF10 (PubMed:22351773). Interacts with BMP5 and BMP7; the interaction inhibits BMP-induced transcription of HAMP (PubMed:30097509). Interacts with BMP6; the interaction inhibits BMP-induced transcription of HAMP (PubMed:30097509, PubMed:31800957). Interacts with BMP2 (PubMed:31800957). Interacts with heterodimers composed of BMP2 and BMP6 in vitro, the interaction inhibits the heterodimer binding to its receptor BMPR1A /ALK3 and thereby suppresses expression of HAMP (PubMed:31800957). Secreted te=Secreted when glycosylated at Asn- 229 and Asn-281 (PubMed:32602701). Hydroxylation promotes secretion (PubMed:32602701). Expressed in the soleus muscle in the leg (at protein level) (PubMed:22351773, PubMed:30566056). Found in blood (at protein level) (PubMed:22351773, PubMed:24187137). Weakly expressed in the heart (at protein level) (PubMed:22351773, PubMed:30566056). Predominantly expressed in skeletal muscle and, at much lower levels, in other tissues, including lung, eye, smooth muscle, brain and kidney (PubMed:22351773, PubMed:24187137). Within skeletal muscles, higher expression levels in soleus as compared with plantaris (PubMed:22351773). Expressed in osteoblasts, mature osteoclasts and erythroblasts (PubMed:34002695). When fasting, females tend to have higher circulating levels than males (PubMed:22351773). Obese mice tend to have lower expression and circulating levels as compared to lean animals (PubMed:22351773). Following EPO treatment, only expressed in bone marrow and spleen (PubMed:24880340). Up-regulated by intracellular increase in cAMP levels, such as those elicited by forskolin and epinephrine treatments, and increase in calcium (ionomycine) (PubMed:22351773). Up-regulated by exercise in skeletal muscle (at protein level) and blood plasma (at protein level) (PubMed:22351773, PubMed:30566056). Drastically down-regulated by fasting (PubMed:22351773, PubMed:24187137). Up-regulated in skeletal muscle by refeeding; the extent of induction by refeeding may be dependent upon the muscle fiber type, being much higher in soleus than in plantaris (PubMed:22351773). Both glucose and lipid are equally potent in this induction, in the absence of any gut-derived hormones (PubMed:22351773). Induced by glucose in the blood; following 24 hours fasting (PubMed:22351773). Induced by glucose and/or amino acids in myotubes (PubMed:24187137). Highly induced within 4 hours of bleeding (PubMed:24880340). Induced by Epo in the spleen and blood (PubMed:24880340, PubMed:31800957). N-glycosylated; required for secretion of the mature protein. Mice are viable and fertile without any abnormal phenotypic features in normal conditions (PubMed:24880340, PubMed:30566056). Following hemorrhage mice show decreased hemoglobin and exhibit a delay in recovery from blood loss, rapid suppression of Hamp/hepcidin is also compromised (PubMed:24880340). Loss of Epo- induced enhancement of erythropoiesis and reduction in Epo-mediated suppression of Hamp and Bmp-target gene transcription, however there is no change in baseline HAMP expression (PubMed:30097509). Significantly reduced whole body, femur and tibia bone mass density (BMD) at 6 weeks and 5 months of age. Increases the mineralizing surface, mineral apposition rate and bone formation rates at 6 weeks of age however no differences are seen at 5 months of age (PubMed:34002695). Increase in osteoclast surface and osteoclast number in femurs of 6 week old mice and 5 month old mice (PubMed:34002695). Increase in Bmp2 levels in the serum and secreted by cultured osteoblasts resulting in activation of Bmp2-mediated signaling pathway targets such as Smad1, Smad5, Smad8, and Erk (PubMed:34002695). Stromal cells from 5 month old mice show enhanced ability to differentiate into mature mineralizing colony forming units ex vivo, this results in increased expression of Runx2, Sp7, Sost, and Tnfsf11/Rankl (PubMed:34002695). In an ischemic reperfusion injury model, there is a significance increase in the area and amount of left ventricular damage, resulting in an increase in left ventricular dysfunction and a reduced ejection fraction (PubMed:30566056). Increase in the number of apoptotic cells in the myocardium of the area at risk (PubMed:30566056). Increase in pro- inflammatory markers Tnf, Il-6 and Ccl2/Mcp-1, the macrophage marker Agre1, and the autophagy marker Lc3II/Lc3I ratio (PubMed:30566056). Decrease in phosphorylation of Akt and Creb1 and abolishes the increase of sphingosine-1-phosphate (S1P) and cAMP levels in cardiomyocytes (PubMed:30566056). Mice with thalassemia intermedia show high levels of Erfe expression, contributing to the suppression of hepcidin and the systemic iron overload characteristic of thalassemia (Probable). May have cardiac protective functions following ischemic reperfusion injury, which are enhanced by exercise-induced expression and secretion from skeletal muscle. Erfe in the blood may act on cardiomyocytes to reduce apoptosis and macrophage inflammation following injury and therefore limit the subsequent area and amount of damage (PubMed:30566056). Belongs to the adipolin/erythroferrone family. Sequence=BAC26362.1; Type=Frameshift; Evidence=; hormone activity extracellular region extracellular space cell cellular iron ion homeostasis signal transduction regulation of glucose metabolic process regulation of fatty acid metabolic process protein homodimerization activity negative regulation of gluconeogenesis positive regulation of glucose import positive regulation of insulin receptor signaling pathway positive regulation of fatty acid transport uc007caj.1 uc007caj.2 
ENSMUST00000086869.6 Yju2 ENSMUST00000086869.6 YJU2 splicing factor (from RefSeq NM_028381.3) Ccdc94 ENSMUST00000086869.1 ENSMUST00000086869.2 ENSMUST00000086869.3 ENSMUST00000086869.4 ENSMUST00000086869.5 NM_028381 Q9D6J3 YJU2_MOUSE Yju2 uc008dak.1 uc008dak.2 uc008dak.3 Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron. Nucleus Belongs to the CWC16 family. YJU2 subfamily. molecular_function nucleus spliceosomal complex mRNA processing biological_process RNA splicing negative regulation of DNA damage response, signal transduction by p53 class mediator metal ion binding U2-type catalytic step 1 spliceosome uc008dak.1 uc008dak.2 uc008dak.3 
ENSMUST00000086876.7 Pot1b ENSMUST00000086876.7 protection of telomeres 1B, transcript variant 1 (from RefSeq NM_028370.2) ENSMUST00000086876.1 ENSMUST00000086876.2 ENSMUST00000086876.3 ENSMUST00000086876.4 ENSMUST00000086876.5 ENSMUST00000086876.6 H7BX60 H7BX60_MOUSE NM_028370 Pot1b uc008dab.1 uc008dab.2 uc008dab.3 Chromosome, telomere Nucleus Belongs to the telombin family. telomere maintenance nuclear telomere cap complex nuclear chromosome, telomeric region regulation of cell growth DNA binding protein binding cell aging telomerase inhibitor activity telomere capping Rab GTPase binding protection from non-homologous end joining at telomere regulation of telomere maintenance via telomerase telomeric DNA binding single-stranded telomeric DNA binding regulation of GTPase activity telomere maintenance in response to DNA damage negative regulation of DNA recombination at telomere regulation of phagocytosis chromosome organization negative regulation of telomerase activity G-rich strand telomeric DNA binding telomeric loop formation uc008dab.1 uc008dab.2 uc008dab.3 
ENSMUST00000086882.8 Asb18 ENSMUST00000086882.8 ankyrin repeat and SOCS box-containing 18, transcript variant 1 (from RefSeq NM_139152.2) ASB18_MOUSE ENSMUST00000086882.1 ENSMUST00000086882.2 ENSMUST00000086882.3 ENSMUST00000086882.4 ENSMUST00000086882.5 ENSMUST00000086882.6 ENSMUST00000086882.7 NM_139152 Q3B7Y5 Q3KNB0 Q8VHA6 uc007bzd.1 uc007bzd.2 uc007bzd.3 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VHA6-1; Sequence=Displayed; Name=2; IsoId=Q8VHA6-2; Sequence=VSP_029624, VSP_029626, VSP_029627; Name=3; IsoId=Q8VHA6-3; Sequence=VSP_029624, VSP_029625; The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Belongs to the ankyrin SOCS box (ASB) family. biological_process protein ubiquitination intracellular signal transduction uc007bzd.1 uc007bzd.2 uc007bzd.3 
ENSMUST00000086923.6 Col17a1 ENSMUST00000086923.6 collagen, type XVII, alpha 1, transcript variant 2 (from RefSeq NM_007732.3) Bp180 Bpag2 COHA1_MOUSE ENSMUST00000086923.1 ENSMUST00000086923.2 ENSMUST00000086923.3 ENSMUST00000086923.4 ENSMUST00000086923.5 NM_007732 Q07563 Q08AT3 Q3UXX1 Q99LK8 uc008hvi.1 uc008hvi.2 uc008hvi.3 uc008hvi.4 May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. The 120 kDa linear IgA disease antigen homolog is an anchoring filament component involved in dermal-epidermal cohesion. Homotrimers of alpha 1(XVII)chains. Interacts (via cytoplasmic region) with ITGB4 (via cytoplasmic region). Interacts (via cytoplasmic region) with DST (via N-terminus). Interacts (via N-terminus) with PLEC. Interacts (via cytoplasmic region) with DSP (By similarity). Q07563; P08246: ELANE; Xeno; NbExp=2; IntAct=EBI-6251005, EBI-986345; Cell junction, hemidesmosome. Membrane; Single- pass type II membrane protein. Note=Localized along the plasma membrane of the hemidesmosome. [120 kDa linear IgA disease antigen homolog]: Secreted, extracellular space, extracellular matrix, basement membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q07563-1; Sequence=Displayed; Name=2; IsoId=Q07563-2; Sequence=VSP_009362; The intracellular/endo domain is disulfide-linked. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. The ectodomain is shedded from the surface of keratinocytes resulting in a 120-kDa soluble form, also named as 120 kDa linear IgA disease antigen homolog. The shedding is mediated by membrane-bound metalloproteases. This cleavage is inhibited by phosphorylation at Ser- 551 (By similarity). extracellular matrix structural constituent protein binding extracellular region collagen trimer basement membrane extracellular space membrane integral component of membrane cell junction hemidesmosome extracellular matrix organization extracellular matrix hemidesmosome assembly uc008hvi.1 uc008hvi.2 uc008hvi.3 uc008hvi.4 
ENSMUST00000086932.10 Tfeb ENSMUST00000086932.10 transcription factor EB, transcript variant 2 (from RefSeq NM_001161722.1) ENSMUST00000086932.1 ENSMUST00000086932.2 ENSMUST00000086932.3 ENSMUST00000086932.4 ENSMUST00000086932.5 ENSMUST00000086932.6 ENSMUST00000086932.7 ENSMUST00000086932.8 ENSMUST00000086932.9 NM_001161722 Q9R210 TFEB_MOUSE Tcfeb Tfeb uc008cwc.1 uc008cwc.2 uc008cwc.3 uc008cwc.4 Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:16936731, PubMed:22343943, PubMed:27278822, PubMed:35662396). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA- binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:16936731, PubMed:27278822). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:35662396). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (By similarity). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (By similarity). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (PubMed:16936731). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (By similarity). Plays a role in the signal transduction processes required for normal vascularization of the placenta (PubMed:9806910). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica (PubMed:24882217, PubMed:27184844, PubMed:35662396). Infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (By similarity). Homodimer and heterodimer; with TFE3 or MITF (By similarity). Interacts (when phosphorylated by MTOR) with YWHAZ; promoting retention in the cytosol (By similarity). Interacts with Irgm1; promoting association between TFEB and PPP3CB and dephosphorylation (By similarity). Interacts with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD); promoting its recruitment to lysosomal membrane in the presence of nutrients (By similarity). Interacts with ACSS2 (By similarity). Nucleus toplasm, cytosol Lysosome membrane Note=Mainly present in the cytoplasm (By similarity). When nutrients are present, recruited to the lysosomal membrane via association with GDP-bound RagC/RRAGC (or RagD/RRAGD): it is then phosphorylated by MTOR (By similarity). Phosphorylation by MTOR prevents nuclear translocation and activity by promoting interaction with 14-3-3 proteins, such as YWHAZ (By similarity). Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus (By similarity). The translocation to the nucleus is regulated by ATP13A2 (PubMed:27278822). Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (By similarity). Exported from the nucleus in response to nutrient availability (By similarity). In macrophages, translocates into the nucleus upon live S.enterica infection (By similarity). Widely expressed. Expressed at low levels in the embryo but at high levels in the labyrinthine trophoblast cells of the placenta. The leucine zipper region is essential for homo- or heterodimerization and high-affinity DNA binding. DNA binding is mediated by the basic region. Phosphorylation at Ser-210 by MTOR via non-canonical mTORC1 pathway regulates its subcellular location and activity (By similarity). When nutrients are present, phosphorylation by MTOR promotes association with 14-3-3/YWHA adapters and retention in the cytosol (By similarity). Inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation by calcineurin PPP3CB and translocation to the nucleus (By similarity). Dephosphorylated by calcineurin PPP3CB in response to lysosomal Ca(2+) release (By similarity). Irgm1 promotes dephosphorylation by calcineurin PPP3CB, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (By similarity). Exported from the nucleus in a mTORC1- dependent manner in response to nutrient availability (By similarity). Alkylated via a non-enzymatic covalent modification (PubMed:35662396). Itaconate, an anti-inflammatory metabolite generated in response to lipopolysaccharide, alkylates Cys-211, preventing association with 14-3-3/YWHA adapters, thereby promoting nuclear translocation and activity (PubMed:35662396). Sumoylated; does not affect dimerization with MITF. Death between 9.5 and 10.5 days in embryonic development (PubMed:9806910). Embryos display severe defects in placental vascularization (PubMed:9806910). The embryonic vasculature forms normally but few vessels are seen entering the placenta and those that do enter fail to thrive and branch normally (PubMed:9806910). Conditional deletion in kidney does not lead to any abnormality in the kidney (PubMed:32612235). Mice lacking Tfeb and Flcn in the kidney do not show any abnormality in the kidney, suggesting that the kidney phenotype observed in Flcn knockout mice is due to constitutive activation of Tfeb (PubMed:32612235). Belongs to the MiT/TFE family. Sequence=AAD20979.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding embryonic placenta development adaptive immune response immune system process DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex cytoplasm regulation of transcription, DNA-templated autophagy humoral immune response lysosome organization positive regulation of autophagy lysosome localization transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity defense response to Gram-negative bacterium regulation of defense response to bacterium, incompatible interaction uc008cwc.1 uc008cwc.2 uc008cwc.3 uc008cwc.4 
ENSMUST00000086950.6 Pramel49 ENSMUST00000086950.6 Belongs to the PRAME family. (from UniProt J3QMM8) ENSMUST00000086950.1 ENSMUST00000086950.2 ENSMUST00000086950.3 ENSMUST00000086950.4 ENSMUST00000086950.5 Gm16429 Gm7971 J3QMM8 J3QMM8_MOUSE L7N204 Pramel36 Pramel49 uc290xgo.1 uc290xgo.2 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xgo.1 uc290xgo.2 
ENSMUST00000086975.7 Gpr55 ENSMUST00000086975.7 G protein-coupled receptor 55 (from RefSeq NM_001033290.3) ENSMUST00000086975.1 ENSMUST00000086975.2 ENSMUST00000086975.3 ENSMUST00000086975.4 ENSMUST00000086975.5 ENSMUST00000086975.6 GPR55_MOUSE Gm218 NM_001033290 Q3UJF0 uc007buq.1 uc007buq.2 uc007buq.3 G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation. In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation. May be involved in hyperalgesia associated with inflammatory and neuropathic pain (PubMed:18502582). Cell membrane ; Multi-pass membrane protein Highly expressed in splenic plasma cells. Mutant mice are resistant to mechanical hyperalgesia and have increased levels of anti-inflammatory cytokines (PubMed:18502582). GPR55 deficiency disturbs metabolism and drives inflammation while B-cell-specific deficiency promotes atherosclerosis with reduced plasma cholesterol levels (PubMed:36523570). Mice also display suppression of the onset of mechanical pain hypersensitivity and spinal recruitment of neutrophils and other inflammatory cells after spinal cord compression (PubMed:36898418). The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity cannabinoid receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway activation of phospholipase C activity membrane integral component of membrane positive regulation of Rho protein signal transduction cannabinoid signaling pathway bone resorption negative regulation of osteoclast differentiation positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway positive regulation of ERK1 and ERK2 cascade uc007buq.1 uc007buq.2 uc007buq.3 
ENSMUST00000086978.12 Cdkl2 ENSMUST00000086978.12 cyclin dependent kinase like 2, transcript variant 1 (from RefSeq NM_016912.2) CDKL2_MOUSE Cdkl2 ENSMUST00000086978.1 ENSMUST00000086978.10 ENSMUST00000086978.11 ENSMUST00000086978.2 ENSMUST00000086978.3 ENSMUST00000086978.4 ENSMUST00000086978.5 ENSMUST00000086978.6 ENSMUST00000086978.7 ENSMUST00000086978.8 ENSMUST00000086978.9 Kkiamre Kkm NM_016912 Q3UL60 Q3V3X7 Q9QUK0 Q9QYI1 Q9QYI2 uc008yce.1 uc008yce.2 uc008yce.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=KKIAMRE-beta; IsoId=Q9QUK0-1; Sequence=Displayed; Name=2; Synonyms=KKIAMRE-gamma; IsoId=Q9QUK0-2; Sequence=VSP_016146, VSP_016147; Expressed in testis, kidney, lung and brain. The [NKR]KIAxRE motif seems to be a cyclin-binding region. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Sequence=BAE43274.1; Type=Erroneous initiation; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus cytoplasm centrosome protein phosphorylation kinase activity phosphorylation transferase activity regulation of cell cycle uc008yce.1 uc008yce.2 uc008yce.3 
ENSMUST00000087012.7 Slc22a7 ENSMUST00000087012.7 solute carrier family 22 (organic anion transporter), member 7 (from RefSeq NM_144856.2) A0A0R4J122 A0A0R4J122_MOUSE ENSMUST00000087012.1 ENSMUST00000087012.2 ENSMUST00000087012.3 ENSMUST00000087012.4 ENSMUST00000087012.5 ENSMUST00000087012.6 NM_144856 Slc22a7 uc008csw.1 uc008csw.2 uc008csw.3 uc008csw.4 Reaction=2'-deoxyguanosine(in) = 2'-deoxyguanosine(out); Xref=Rhea:RHEA:76215, ChEBI:CHEBI:17172; Evidence=; Reaction=2-oxoglutarate(in) = 2-oxoglutarate(out); Xref=Rhea:RHEA:76231, ChEBI:CHEBI:16810; Evidence=; Reaction=3',5'-cyclic AMP(in) = 3',5'-cyclic AMP(out); Xref=Rhea:RHEA:76223, ChEBI:CHEBI:58165; Evidence=; Reaction=3',5'-cyclic GMP(in) = 3',5'-cyclic GMP(out); Xref=Rhea:RHEA:76207, ChEBI:CHEBI:57746; Evidence=; Reaction=GDP(in) = GDP(out); Xref=Rhea:RHEA:76219, ChEBI:CHEBI:58189; Evidence=; Reaction=GMP(in) = GMP(out); Xref=Rhea:RHEA:76211, ChEBI:CHEBI:58115; Evidence=; Reaction=GTP(in) = GTP(out); Xref=Rhea:RHEA:75787, ChEBI:CHEBI:37565; Evidence=; Reaction=L-glutamate(in) + orotate(out) = L-glutamate(out) + orotate(in); Xref=Rhea:RHEA:72043, ChEBI:CHEBI:29985, ChEBI:CHEBI:30839; Evidence=; Reaction=creatinine(in) = creatinine(out); Xref=Rhea:RHEA:74539, ChEBI:CHEBI:16737; Evidence=; Reaction=estrone 3-sulfate(out) = estrone 3-sulfate(in); Xref=Rhea:RHEA:71835, ChEBI:CHEBI:60050; Evidence=; Reaction=glutarate(in) = glutarate(out); Xref=Rhea:RHEA:76251, ChEBI:CHEBI:30921; Evidence=; Reaction=guanosine(in) = guanosine(out); Xref=Rhea:RHEA:75371, ChEBI:CHEBI:16750; Evidence=; Reaction=prostaglandin E2(out) = prostaglandin E2(in); Xref=Rhea:RHEA:50984, ChEBI:CHEBI:606564; Evidence=; Reaction=urate(out) = urate(in); Xref=Rhea:RHEA:60368, ChEBI:CHEBI:17775; Evidence=; Basolateral cell membrane ; Multi-pass membrane protein Lateral cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. organic anion transmembrane transporter activity organic anion transport membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008csw.1 uc008csw.2 uc008csw.3 uc008csw.4 
ENSMUST00000087026.13 Polr1c ENSMUST00000087026.13 polymerase (RNA) I polypeptide C (from RefSeq NM_009085.2) ENSMUST00000087026.1 ENSMUST00000087026.10 ENSMUST00000087026.11 ENSMUST00000087026.12 ENSMUST00000087026.2 ENSMUST00000087026.3 ENSMUST00000087026.4 ENSMUST00000087026.5 ENSMUST00000087026.6 ENSMUST00000087026.7 ENSMUST00000087026.8 ENSMUST00000087026.9 NM_009085 P52432 Polr1c Q3UJZ9 RPAC1_MOUSE Rpo1-1 uc008csc.1 uc008csc.2 uc008csc.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursor pre-rRNA and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. POLR1C/RPAC1 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft (By similarity). Component of the RNA polymerase I and RNA polymerase III complexes consisting of at least 13 and 17 subunits, respectively. The transcriptionally active RNA polymerase III complex consists of a ten- subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4- POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Nucleus Cytoplasm, cytosol Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. Sequence=BAA06735.1; Type=Erroneous initiation; Evidence=; DNA binding DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm DNA-directed RNA polymerase III complex DNA-directed RNA polymerase I complex transcription, DNA-templated transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter transcription from RNA polymerase III promoter biological_process protein dimerization activity RNA polymerase I activity RNA polymerase III activity uc008csc.1 uc008csc.2 uc008csc.3 
ENSMUST00000087031.7 Xpo5 ENSMUST00000087031.7 exportin 5 (from RefSeq NM_028198.3) A2RRJ5 ENSMUST00000087031.1 ENSMUST00000087031.2 ENSMUST00000087031.3 ENSMUST00000087031.4 ENSMUST00000087031.5 ENSMUST00000087031.6 Kiaa1291 NM_028198 Q7TMP2 Q80TF9 Q924C1 Q9CRI9 Q9CT48 Ranbp21 XPO5_MOUSE uc008csa.1 uc008csa.2 uc008csa.3 Mediates the nuclear export of proteins bearing a double- stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi) (By similarity). Mediates nuclear export of ADAR/ADAR1 in a RanGTP-dependent manner (By similarity). Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence- independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP (By similarity). Component of a nuclear export receptor complex composed of XPO5, RAN, dsRNA-binding proteins and dsRNA. Found in a nuclear export complex with XPO5, RAN, EEF1A1, and aminoacylated tRNA. Found in a nuclear export complex with XPO5, RAN, ILF3 and dsRNA. Found in a nuclear export complex with XPO5, RAN and pre-miRNA. Found in a nuclear export complex with XPO5, RAN, ILF3 and minihelix VA1 dsRNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and dsRNA. Interacts with EEF1A1, ILF3, NUP153, NUP214 and ZNF346. Interacts with RAN and cargo proteins in a GTP-dependent manner. Interacts with ADAR/ADAR1 (via DRBM domains). Interacts with SMAD4; mediates nuclear export of SMAD4. Interacts with RAN (GTP-bound form). Nucleus Cytoplasm Note=Shuttles between the nucleus and the cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q924C1-1; Sequence=Displayed; Name=2; IsoId=Q924C1-2; Sequence=VSP_018462, VSP_018465; Name=3; IsoId=Q924C1-3; Sequence=VSP_018463, VSP_018464; Belongs to the exportin family. tRNA binding RNA binding mRNA binding nuclear export signal receptor activity nucleus nucleoplasm cytoplasm cytosol protein export from nucleus intracellular protein transport Ran GTPase binding protein transport RISC complex gene silencing by RNA pre-miRNA export from nucleus RNA nuclear export complex regulation of protein export from nucleus nuclear export pre-miRNA binding positive regulation of RNA interference RISC complex binding uc008csa.1 uc008csa.2 uc008csa.3 
ENSMUST00000087033.6 Jchain ENSMUST00000087033.6 immunoglobulin joining chain (from RefSeq NM_152839.4) ENSMUST00000087033.1 ENSMUST00000087033.2 ENSMUST00000087033.3 ENSMUST00000087033.4 ENSMUST00000087033.5 IGJ_MOUSE Igj Jchain NM_152839 P01592 uc008xzu.1 uc008xzu.2 uc008xzu.3 uc008xzu.4 Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component. Part of the secretory IgA (sIgA) complex that consists of two, four or five IgA monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteolytic product of PIGR). Part of the secretory IgM (sIgM) complex that consist of five IgM monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteolytic product of PIGR). JCHAIN- containing IgM interacts (via CH4 domain) with FCRM (via Ig-like domain). Secreted adaptive immune response glomerular filtration single-stranded DNA binding antigen binding extracellular region extracellular space humoral immune response antibacterial humoral response IgA binding protein binding, bridging phosphatidylcholine binding positive regulation of protein oligomerization immunoglobulin receptor binding protein homodimerization activity peptidoglycan binding innate immune response positive regulation of respiratory burst monomeric IgA immunoglobulin complex dimeric IgA immunoglobulin complex secretory IgA immunoglobulin complex secretory dimeric IgA immunoglobulin complex pentameric IgM immunoglobulin complex uc008xzu.1 uc008xzu.2 uc008xzu.3 uc008xzu.4 
ENSMUST00000087043.8 Smr2 ENSMUST00000087043.8 submaxillary gland androgen regulated protein 2, transcript variant 1 (from RefSeq NM_021289.2) ENSMUST00000087043.1 ENSMUST00000087043.2 ENSMUST00000087043.3 ENSMUST00000087043.4 ENSMUST00000087043.5 ENSMUST00000087043.6 ENSMUST00000087043.7 Msg2 NM_021289 O35985 SMR2C_MOUSE Vcs2 uc008xzl.1 uc008xzl.2 May play a role in protection or detoxification. Secreted. Event=Alternative splicing; Named isoforms=5; Name=Gamma; IsoId=O35985-1; Sequence=Displayed; Name=Alpha; IsoId=O09133-1; Sequence=External; Name=Beta; IsoId=O35982-1; Sequence=External; Name=Delta; IsoId=O35979-1; Sequence=External; Name=Epsilon; IsoId=O35961-1; Sequence=External; endopeptidase inhibitor activity extracellular region response to toxic substance negative regulation of endopeptidase activity regulation of sensory perception of pain uc008xzl.1 uc008xzl.2 
ENSMUST00000087050.7 Col4a4 ENSMUST00000087050.7 collagen, type IV, alpha 4 (from RefSeq NM_007735.2) CO4A4_MOUSE Col4a4 ENSMUST00000087050.1 ENSMUST00000087050.2 ENSMUST00000087050.3 ENSMUST00000087050.4 ENSMUST00000087050.5 ENSMUST00000087050.6 NM_007735 Q149M2 Q64457 Q9QZR9 uc033fjy.1 uc033fjy.2 uc033fjy.3 uc033fjy.4 Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. The alpha 3(IV) chain forms a triple helical protomer with alpha 4(IV) and alpha 5(IV); this triple helical structure dimerizes through NC1-NC1 domain interactions such that the alpha 3(IV), alpha 4(IV) and alpha 5(IV) chains of one protomer connect with the alpha 5(IV), alpha 4(IV) and alpha 3(IV) chains of the opposite protomer, respectively (By similarity). Associates with LAMB2 at the neuromuscular junction and in GBM. Secreted, extracellular space, extracellular matrix, basement membrane te=Colocalizes with COL4A3 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q9QZR9-1; Sequence=Displayed; Name=2 ; IsoId=Q9QZR9-2; Sequence=VSP_052356, VSP_052357; Expressed in Bruch's membrane, outer plexiform layer, inner nuclear layer, inner plexiform layer, ganglion cell layer, inner limiting membrane and around the blood vessels of the retina (at protein level) (PubMed:29777959). Highly expressed in kidney and lung (PubMed:7962065). Detected at lower levels in heart, muscle and skin (PubMed:7962065). The expression of collagen IV undergoes a developmental shift in the developing lens capsule. During the early stages of lens capsule development expression of collagens alpha 1(IV), alpha 2(IV), alpha 5(IV) and alpha 6(IV) is observed; this is consistent with the presence of fibrillar alpha 1(IV)-alpha 1(IV)-alpha 2(IV) protomers and of elastic alpha 5(IV)-alpha 5(IV)-alpha 6(IV) protomers. In the later stages of development components of the more cross-linked alpha 3(IV)-alpha 4(IV)-alpha 5(IV) protomer appear. Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues. The kidneys of transgenic mice where the 5' portions of both COL4A3 and COL4A4 and the shared intergenic promoter region were deleted exhibit morphological and ultrastructural features characteristic of the human hereditary disorder Alport syndrome, including disorganization and multilamellar structure of the GBM and delayed onset glomerulonephritis. Belongs to the type IV collagen family. extracellular matrix structural constituent extracellular region collagen trimer collagen type IV trimer basement membrane extracellular space extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix glomerular basement membrane development collagen-activated tyrosine kinase receptor signaling pathway uc033fjy.1 uc033fjy.2 uc033fjy.3 uc033fjy.4 
ENSMUST00000087052.11 Cibar1 ENSMUST00000087052.11 CBY1 interacting BAR domain containing 1, transcript variant 2 (from RefSeq NM_001310743.1) Cibar1 ENSMUST00000087052.1 ENSMUST00000087052.10 ENSMUST00000087052.2 ENSMUST00000087052.3 ENSMUST00000087052.4 ENSMUST00000087052.5 ENSMUST00000087052.6 ENSMUST00000087052.7 ENSMUST00000087052.8 ENSMUST00000087052.9 Fam92a NM_001310743 Z4YJZ2 Z4YJZ2_MOUSE uc033iar.1 uc033iar.2 uc033iar.3 uc033iar.4 Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Nucleus Belongs to the CIBAR family. uc033iar.1 uc033iar.2 uc033iar.3 uc033iar.4 
ENSMUST00000087092.4 Mrgpra4 ENSMUST00000087092.4 MAS-related GPR, member A4 (from RefSeq NM_153524.2) ENSMUST00000087092.1 ENSMUST00000087092.2 ENSMUST00000087092.3 Mgrg10 Mrgpra4 NM_153524 W8W3F5 W8W3F5_MOUSE uc009hak.1 uc009hak.2 uc009hak.3 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009hak.1 uc009hak.2 uc009hak.3 
ENSMUST00000087114.5 Cenpq ENSMUST00000087114.5 centromere protein Q (from RefSeq NM_031863.4) CENPQ_MOUSE ENSMUST00000087114.1 ENSMUST00000087114.2 ENSMUST00000087114.3 ENSMUST00000087114.4 NM_031863 Q8C2G4 Q8VEF8 Q9CPQ5 Q9CX70 uc008con.1 uc008con.2 uc008con.3 Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Nucleus Chromosome, centromere Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CPQ5-1; Sequence=Displayed; Name=2; IsoId=Q9CPQ5-2; Sequence=VSP_020451, VSP_020452; Phosphorylation at Ser-49 is essential for CENPE recruitment to kinetochores and orderly chromosome congression. Belongs to the CENP-Q/OKP1 family. Sequence=BAB27968.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB28080.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB31976.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB31976.1; Type=Frameshift; Evidence=; Sequence=BAC36178.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC40501.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; chromosome, centromeric region kinetochore nucleus nucleoplasm chromosome actin cytoskeleton metaphase plate congression positive regulation of protein localization to kinetochore uc008con.1 uc008con.2 uc008con.3 
ENSMUST00000087122.12 Speg ENSMUST00000087122.12 SPEG complex locus, transcript variant 1 (from RefSeq NM_007463.5) E9QQ25 E9QQ25_MOUSE ENSMUST00000087122.1 ENSMUST00000087122.10 ENSMUST00000087122.11 ENSMUST00000087122.2 ENSMUST00000087122.3 ENSMUST00000087122.4 ENSMUST00000087122.5 ENSMUST00000087122.6 ENSMUST00000087122.7 ENSMUST00000087122.8 ENSMUST00000087122.9 NM_007463 Speg uc007boz.1 uc007boz.2 uc007boz.3 uc007boz.4 This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants that encode different protein isoforms have been defined. [provided by RefSeq, Mar 2010]. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus protein phosphorylation kinase activity phosphorylation transferase activity muscle cell differentiation uc007boz.1 uc007boz.2 uc007boz.3 uc007boz.4 
ENSMUST00000087143.7 Eif1ax ENSMUST00000087143.7 eukaryotic translation initiation factor 1A, X-linked (from RefSeq NM_025437.5) ENSMUST00000087143.1 ENSMUST00000087143.2 ENSMUST00000087143.3 ENSMUST00000087143.4 ENSMUST00000087143.5 ENSMUST00000087143.6 Eif1ay IF1AX_MOUSE NM_025437 Q3UY50 Q6ZWL8 Q8BJZ2 Q8BMH8 Q8BMJ3 Q9CSL9 uc009usm.1 uc009usm.2 uc009usm.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Component of the 43S pre-initiation complex (43S PIC), which is composed of the 40S ribosomal subunit, EIF1, eIF1A (EIF1AX), eIF3 complex, EIF5 and eIF2-GTP-initiator tRNA complex (eIF2 ternary complex). Interacts with EIF5; this interaction contributes to the maintenance of EIF1 within the open 43S PIC. Interacts through its C- terminal domain (CTD) with the CTD of EIF5B; from the location of the start codon by the 43S complex until the formation of the 80S complex. Cytoplasm Belongs to the eIF-1A family. RNA binding translation initiation factor activity cellular_component translation translational initiation uc009usm.1 uc009usm.2 uc009usm.3 
ENSMUST00000087155.5 Frat1 ENSMUST00000087155.5 frequently rearranged in advanced T cell lymphomas (from RefSeq NM_008043.3) ENSMUST00000087155.1 ENSMUST00000087155.2 ENSMUST00000087155.3 ENSMUST00000087155.4 FRAT1_MOUSE NM_008043 P70339 uc008hmi.1 uc008hmi.2 uc008hmi.3 Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation. Cytoplasm Highly expressed in testis. Lower level of expression in spleen, thymus and brain. Expressed at low levels during embryonic development. Phosphorylated. Note=Activation contributes to progression of mouse T-cell lymphomas (PubMed:9034327). Belongs to the GSK-3-binding protein family. embryonic axis specification protein binding nucleus cytoplasm cytosol protein export from nucleus intracellular membrane-bounded organelle canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway Wnt signaling pathway uc008hmi.1 uc008hmi.2 uc008hmi.3 
ENSMUST00000087157.5 Klhl34 ENSMUST00000087157.5 kelch-like 34 (from RefSeq NM_001081667.3) A2AI76 A2AI76_MOUSE ENSMUST00000087157.1 ENSMUST00000087157.2 ENSMUST00000087157.3 ENSMUST00000087157.4 Klhl34 NM_001081667 uc009usg.1 uc009usg.2 uc009usg.3 uc009usg.4 uc009usg.1 uc009usg.2 uc009usg.3 uc009usg.4 
ENSMUST00000087158.11 Trim40 ENSMUST00000087158.11 tripartite motif-containing 40, transcript variant 1 (from RefSeq NM_001033235.3) B2RVT3 ENSMUST00000087158.1 ENSMUST00000087158.10 ENSMUST00000087158.2 ENSMUST00000087158.3 ENSMUST00000087158.4 ENSMUST00000087158.5 ENSMUST00000087158.6 ENSMUST00000087158.7 ENSMUST00000087158.8 ENSMUST00000087158.9 Gm319 NM_001033235 Q3UWA4 TRI40_MOUSE uc008clk.1 uc008clk.2 uc008clk.3 uc008clk.4 E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation. Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Interacts with NEDD8. TRIM40 deficiency greatly enhances antiviral immune responses and interferon-beta production and thus inhibits viral replication. Belongs to the TRIM/RBCC family. zinc ion binding IkappaB kinase complex negative regulation of cell growth negative regulation of NF-kappaB transcription factor activity negative regulation of protein catabolic process protein neddylation metal ion binding negative regulation of protein localization to nucleus uc008clk.1 uc008clk.2 uc008clk.3 uc008clk.4 
ENSMUST00000087167.5 H2-M9 ENSMUST00000087167.5 histocompatibility 2, M region locus 9, transcript variant 2 (from RefSeq NM_008205.1) ENSMUST00000087167.1 ENSMUST00000087167.2 ENSMUST00000087167.3 ENSMUST00000087167.4 H2-M9 M9 NM_008205 O19442 O19442_MOUSE uc008clc.1 uc008clc.2 uc008clc.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc008clc.1 uc008clc.2 uc008clc.3 
ENSMUST00000087176.8 Opalin ENSMUST00000087176.8 oligodendrocytic myelin paranodal and inner loop protein (from RefSeq NM_153520.2) ENSMUST00000087176.1 ENSMUST00000087176.2 ENSMUST00000087176.3 ENSMUST00000087176.4 ENSMUST00000087176.5 ENSMUST00000087176.6 ENSMUST00000087176.7 NM_153520 OPALI_MOUSE Q6P903 Q7M750 Tmem10 uc008hlq.1 uc008hlq.2 uc008hlq.3 uc008hlq.4 Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation. Cell membrane ingle-pass type I membrane protein Note=In the CNS, enriched in the myelin paranodal and inner loop membranes, but not that of the PNS. Enriched in the leading edge of extending processes (PubMed:30837646). Expressed specifically in oligodendrocytes of the brain. Expression in the cerebellum increases dramatically after the first postnatal week (PubMed:18490449, PubMed:30837646). Selectively expressed in brain at P21, and not expressed in any other tissues tested including thymus, lung, heart, liver, spleen, kidney and testis. By leukemia inhibitory factor (LIF) and cAMP analogs. Suppressed in the presence of astrocytic or neural-stem-like differentiation factors such as bone morphotic protein (BMP) and fetal calf serum. Deficient mice are born the expected Mendelian ratio and have a normal body shape and weight. No obvious abnormalities in gross anatomy or major myelin protein components nor in the compartment of myelinated axons and oligodendrocyte maturation. Nevertheless, deficient mice display increased exploratory activity in a novel environment. molecular_function Golgi apparatus plasma membrane biological_process membrane integral component of membrane cell-cell contact zone uc008hlq.1 uc008hlq.2 uc008hlq.3 uc008hlq.4 
ENSMUST00000087177.4 Lrrc66 ENSMUST00000087177.4 leucine rich repeat containing 66 (from RefSeq NM_153568.2) ENSMUST00000087177.1 ENSMUST00000087177.2 ENSMUST00000087177.3 LRC66_MOUSE NM_153568 Q8K0B3 uc008xta.1 uc008xta.2 uc008xta.3 Membrane ; Multi-pass membrane protein membrane integral component of membrane uc008xta.1 uc008xta.2 uc008xta.3 
ENSMUST00000087183.11 Stk36 ENSMUST00000087183.11 serine/threonine kinase 36, transcript variant 7 (from RefSeq NR_175805.1) ENSMUST00000087183.1 ENSMUST00000087183.10 ENSMUST00000087183.2 ENSMUST00000087183.3 ENSMUST00000087183.4 ENSMUST00000087183.5 ENSMUST00000087183.6 ENSMUST00000087183.7 ENSMUST00000087183.8 ENSMUST00000087183.9 Kiaa1278 NR_175805 Q69ZM6 Q6PDI0 Q80XQ6 STK36_MOUSE Stk36 uc007bmv.1 uc007bmv.2 uc007bmv.3 uc007bmv.4 Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with SPAG16 and KIF27. Q69ZM6; Q7M6Z4: Kif27; NbExp=2; IntAct=EBI-15765145, EBI-15765182; Cytoplasm Nucleus Cytoplasm, cytoskeleton, cilium axoneme. Note=Low levels also present in the nucleus. Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q69ZM6-1; Sequence=Displayed; Name=2 ; IsoId=Q69ZM6-2; Sequence=VSP_040760, VSP_040762, VSP_040763; Name=3 ; IsoId=Q69ZM6-3; Sequence=VSP_040761; Weakly expressed in the heart and thymus, present at moderate to high levels in the lungs, pancreas, and kidneys and at higher levels in the brain and cerebellum. Very highly expressed in the testis. At 13.5 dpc is widely distributed in the forebrain, midbrain, hindbrain, spinal cord, somites, developing limb buds and skin. Mice display profound growth retardation with a communicating form of hydrocephalus, nasal inflammation and early mortality. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Sequence=AAH43103.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence=; Sequence=BAD32420.1; Type=Frameshift; Evidence=; nucleotide binding epithelial cilium movement protein kinase activity protein serine/threonine kinase activity protein binding ATP binding extracellular region nucleus cytoplasm cytosol protein phosphorylation positive regulation of hh target transcription factor activity multicellular organism development brain development transcription factor binding post-embryonic development kinase activity phosphorylation transferase activity cell projection organization positive regulation of smoothened signaling pathway metal ion binding regulation of sequence-specific DNA binding transcription factor activity cilium assembly uc007bmv.1 uc007bmv.2 uc007bmv.3 uc007bmv.4 
ENSMUST00000087195.9 Ociad2 ENSMUST00000087195.9 OCIA domain containing 2, transcript variant 1 (from RefSeq NM_026950.4) ENSMUST00000087195.1 ENSMUST00000087195.2 ENSMUST00000087195.3 ENSMUST00000087195.4 ENSMUST00000087195.5 ENSMUST00000087195.6 ENSMUST00000087195.7 ENSMUST00000087195.8 NM_026950 OCAD2_MOUSE Q9D8W7 uc008xsw.1 uc008xsw.2 uc008xsw.3 uc008xsw.4 Endosome molecular_function mitochondrion mitochondrial inner membrane endosome response to bacterium uc008xsw.1 uc008xsw.2 uc008xsw.3 uc008xsw.4 
ENSMUST00000087200.4 Gnl1 ENSMUST00000087200.4 guanine nucleotide binding protein-like 1 (from RefSeq NM_008136.2) E9QPZ9 ENSMUST00000087200.1 ENSMUST00000087200.2 ENSMUST00000087200.3 GNL1_MOUSE Gna-rs1 Mmr1 NM_008136 P36916 Q91Z20 uc008cjo.1 uc008cjo.2 uc008cjo.3 Possible regulatory or functional link with the histocompatibility cluster. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P36916-1; Sequence=Displayed; Name=2; IsoId=P36916-2; Sequence=VSP_026994, VSP_026995; In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern. Belongs to the TRAFAC class YlqF/YawG GTPase family. nucleotide binding GTP binding cellular response to DNA damage stimulus uc008cjo.1 uc008cjo.2 uc008cjo.3 
ENSMUST00000087204.9 Fry ENSMUST00000087204.9 FRY microtubule binding protein (from RefSeq NM_172887.2) E9Q8I9 ENSMUST00000087204.1 ENSMUST00000087204.2 ENSMUST00000087204.3 ENSMUST00000087204.4 ENSMUST00000087204.5 ENSMUST00000087204.6 ENSMUST00000087204.7 ENSMUST00000087204.8 FRY_MOUSE Kiaa4143 NM_172887 Q4VA57 Q5DTL4 Q8BIW6 Q8BUA0 Q8CG91 uc009atv.1 uc009atv.2 uc009atv.3 uc009atv.4 Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. When phosphorylated by CDK1, interacts with PLK1; this interaction occurs in mitotic cells, but not in interphase cells, and leads to further FRY phosphorylation by PLK1. Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Note=Distributed diffusely throughout the cytoplasm in interphase. Localizes to the separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase, to spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with PLK1 to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=E9Q8I9-1; Sequence=Displayed; Name=2; IsoId=E9Q8I9-2; Sequence=VSP_044444, VSP_044445; Name=3; IsoId=E9Q8I9-3; Sequence=VSP_044441, VSP_044442, VSP_044443; Phosphorylated by AURKA, CDK1 and PLK1. [Isoform 2]: May be due to an intron retention. Belongs to the furry protein family. Sequence=BAC37538.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cell morphogenesis spindle pole enzyme inhibitor activity cytoplasm microtubule organizing center cytoskeleton cell cortex neuron projection development negative regulation of catalytic activity negative regulation of tubulin deacetylation uc009atv.1 uc009atv.2 uc009atv.3 uc009atv.4 
ENSMUST00000087211.9 Ppp1r10 ENSMUST00000087211.9 Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. (from UniProt Q80W00) B1B179 BC052059 Cat53 ENSMUST00000087211.1 ENSMUST00000087211.2 ENSMUST00000087211.3 ENSMUST00000087211.4 ENSMUST00000087211.5 ENSMUST00000087211.6 ENSMUST00000087211.7 ENSMUST00000087211.8 PP1RA_MOUSE Pnuts Q80W00 Q811B6 Q8C6T7 Q8K2U8 uc033hdm.1 uc033hdm.2 uc033hdm.3 Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC (By similarity). Interacts with PPP1CA, WDR82 and TOX4. Q80W00; Q15554: TERF2; Xeno; NbExp=3; IntAct=EBI-2553719, EBI-706637; Nucleus Note=Found in discrete nucleoplasmic bodies and within nucleoli (By similarity). Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80W00-1; Sequence=Displayed; Name=2; IsoId=Q80W00-2; Sequence=VSP_013155; Phosphorylated on Thr-398 by PKA within the region necessary for interaction with PPP1CA. nuclear chromosome, telomeric region chromatin nuclear chromatin DNA binding RNA binding protein phosphatase inhibitor activity protein binding nucleus nucleoplasm protein phosphatase 1 binding negative regulation of cardiac muscle cell apoptotic process nuclear body positive regulation of telomere maintenance negative regulation of phosphoprotein phosphatase activity metal ion binding PTW/PP1 phosphatase complex negative regulation of mitotic DNA damage checkpoint uc033hdm.1 uc033hdm.2 uc033hdm.3 
ENSMUST00000087212.8 Nipal1 ENSMUST00000087212.8 NIPA-like domain containing 1 (from RefSeq NM_001081205.1) ENSMUST00000087212.1 ENSMUST00000087212.2 ENSMUST00000087212.3 ENSMUST00000087212.4 ENSMUST00000087212.5 ENSMUST00000087212.6 ENSMUST00000087212.7 NIPA3_MOUSE NM_001081205 Nipa3 Npal1 Q8BMW7 uc008xrv.1 uc008xrv.2 uc008xrv.3 Acts as a Mg(2+) transporter (PubMed:18667602). Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (PubMed:18667602). Shown to promote insulin content and secretion in Min6-K8 cells, particularly under conditions of hypomagnesemia (PubMed:32439805). Reaction=Mg(2+)(in) = Mg(2+)(out); Xref=Rhea:RHEA:29827, ChEBI:CHEBI:18420; Evidence=; Kinetic parameters: KM=0.90 mM for magnesium ions ; Golgi apparatus membrane ; Multi-pass membrane protein Expressed in the pancreatic islets. Up-regulated by low magnesium ion levels. Belongs to the NIPA family. Sequence=BAC25435.1; Type=Frameshift; Evidence=; molecular_function ion transport magnesium ion transmembrane transporter activity magnesium ion transport membrane integral component of membrane magnesium ion transmembrane transport uc008xrv.1 uc008xrv.2 uc008xrv.3 
ENSMUST00000087213.12 Cnga1 ENSMUST00000087213.12 cyclic nucleotide gated channel alpha 1 (from RefSeq NM_007723.2) B9EJ09 CNGA1_MOUSE Cncg Cncg1 ENSMUST00000087213.1 ENSMUST00000087213.10 ENSMUST00000087213.11 ENSMUST00000087213.2 ENSMUST00000087213.3 ENSMUST00000087213.4 ENSMUST00000087213.5 ENSMUST00000087213.6 ENSMUST00000087213.7 ENSMUST00000087213.8 ENSMUST00000087213.9 NM_007723 P29974 Q60776 uc008xrr.1 uc008xrr.2 uc008xrr.3 Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. Forms a heterotetramer with CNGB1 in a 3:1 ratio. May also form cyclic nucleotide-activated homotetrameric channels, that are efficiently activated by saturating cGMP, but poorly activated by saturating cAMP compared to the heterotetramer with CNGB1. Cell membrane ; Multi-pass membrane protein Rod cells in the retina and inner medulla of kidney. The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily. nucleotide binding photoreceptor outer segment ion channel activity intracellular cyclic nucleotide activated cation channel activity intracellular cAMP activated cation channel activity intracellular cGMP activated cation channel activity cytoplasm ion transport visual perception membrane integral component of membrane intracellular cyclic nucleotide activated cation channel complex cGMP binding photoreceptor outer segment membrane terminal bouton response to stimulus regulation of cytosolic calcium ion concentration membrane depolarization transmembrane transport cation transmembrane transport uc008xrr.1 uc008xrr.2 uc008xrr.3 
ENSMUST00000087215.7 Cnot9 ENSMUST00000087215.7 CCR4-NOT transcription complex, subunit 9 (from RefSeq NM_021383.5) CNOT9_MOUSE Cnot9 ENSMUST00000087215.1 ENSMUST00000087215.2 ENSMUST00000087215.3 ENSMUST00000087215.4 ENSMUST00000087215.5 ENSMUST00000087215.6 NM_021383 Q9JKY0 Rcd1 Rqcd1 uc007bmf.1 uc007bmf.2 uc007bmf.3 uc007bmf.4 Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down- regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Required for retinoic acid-induced differentiation of F9 teratocarcinoma cells. Does not bind DNA by itself. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation. Homodimer. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. Interacts with MYB, ATF2, RARA, RARB, RARG, RXRA, RXRB and RXRG. Identified in a complex with ATF2 bound to target DNA. Interacts with NANOS2. Directly interacts with ZNF335 (By similarity). Nucleus Cytoplasm, P-body Note=NANOS2 promotes its localization to P-body. Detected at low levels in bone marrow and thymus. Up-regulated by EPO and EGF. Transiently up-regulated by retinoic acid in F9 teratocarcinoma cells. Belongs to the CNOT9 family. P-body epidermal growth factor receptor binding protein binding nucleus cytoplasm mRNA catabolic process regulation of translation negative regulation of translation cytokine-mediated signaling pathway kinase binding protein domain specific binding CCR4-NOT complex CCR4-NOT core complex gene silencing by RNA macromolecular complex positive regulation of peptidyl-serine phosphorylation negative regulation of intracellular estrogen receptor signaling pathway protein homodimerization activity positive regulation of epidermal growth factor receptor signaling pathway positive regulation of ligand-dependent nuclear receptor transcription coactivator activity uc007bmf.1 uc007bmf.2 uc007bmf.3 uc007bmf.4 
ENSMUST00000087216.12 Nfxl1 ENSMUST00000087216.12 nuclear transcription factor, X-box binding-like 1, transcript variant 1 (from RefSeq NM_133921.3) E9Q8I7 E9Q8I7_MOUSE ENSMUST00000087216.1 ENSMUST00000087216.10 ENSMUST00000087216.11 ENSMUST00000087216.2 ENSMUST00000087216.3 ENSMUST00000087216.4 ENSMUST00000087216.5 ENSMUST00000087216.6 ENSMUST00000087216.7 ENSMUST00000087216.8 ENSMUST00000087216.9 NM_133921 Nfxl1 uc008xrl.1 uc008xrl.2 uc008xrl.3 Belongs to the NFX1 family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter zinc ion binding membrane integral component of membrane uc008xrl.1 uc008xrl.2 uc008xrl.3 
ENSMUST00000087226.11 Pnkd ENSMUST00000087226.11 Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. (from UniProt Q69ZP3) BC058945 Brp17 ENSMUST00000087226.1 ENSMUST00000087226.10 ENSMUST00000087226.2 ENSMUST00000087226.3 ENSMUST00000087226.4 ENSMUST00000087226.5 ENSMUST00000087226.6 ENSMUST00000087226.7 ENSMUST00000087226.8 ENSMUST00000087226.9 Fksg19 Kiaa1184 MNCb-5687 Mr1 PNKD_MOUSE Q3TLE6 Q69ZP3 Q6PD45 Q8BRV8 Q920D4 Q9CSF5 Q9D765 Q9JJA3 Tahccp2 uc007blu.1 uc007blu.2 uc007blu.3 Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. Isoform 2 interacts with the sarcomeric proteins, MRLC2, MYOM1 and ENO3. [Isoform 1]: Membrane; Peripheral membrane protein. [Isoform 2]: Cytoplasm. Nucleus. [Isoform 4]: Mitochondrion Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q69ZP3-1; Sequence=Displayed; Name=2; IsoId=Q69ZP3-2; Sequence=VSP_027743, VSP_027744; Name=3; IsoId=Q69ZP3-3; Sequence=VSP_027742; Name=4; IsoId=Q69ZP3-4; Sequence=VSP_027741; Expressed in many discrete areas of the brain. By Hepatitis C virus core protein. Mice overexpressing Pnkd infused with angiotensin II develop greater cardiac hypertrophy as well as increased cardiac inflammation and fibrosis, compared with angiotensin II-infused normal mice. In these mice, Pnkd overexpression promote nuclear factor kappa B activation. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. Sequence=BAC30873.1; Type=Erroneous initiation; Evidence=; Sequence=BAD32403.1; Type=Erroneous initiation; Evidence=; hydroxyacylglutathione hydrolase activity protein binding nucleus cytoplasm mitochondrion membrane hydrolase activity methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione regulation of synaptic transmission, dopaminergic regulation of dopamine metabolic process metal ion binding negative regulation of neurotransmitter secretion neuromuscular process controlling posture uc007blu.1 uc007blu.2 uc007blu.3 
ENSMUST00000087228.11 Guf1 ENSMUST00000087228.11 GUF1 homolog, GTPase, transcript variant 1 (from RefSeq NM_172711.3) ENSMUST00000087228.1 ENSMUST00000087228.10 ENSMUST00000087228.2 ENSMUST00000087228.3 ENSMUST00000087228.4 ENSMUST00000087228.5 ENSMUST00000087228.6 ENSMUST00000087228.7 ENSMUST00000087228.8 ENSMUST00000087228.9 GUF1_MOUSE NM_172711 Q6PEN7 Q8BPS6 Q8C3X4 uc008xqm.1 uc008xqm.2 uc008xqm.3 uc008xqm.4 Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence= Mitochondrion inner membrane eripheral membrane protein atrix side Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C3X4-1; Sequence=Displayed; Name=2; IsoId=Q8C3X4-2; Sequence=VSP_021345; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily. nucleotide binding GTPase activity GTP binding mitochondrion mitochondrial inner membrane mitochondrial matrix translation membrane hydrolase activity ribosome binding positive regulation of translation uc008xqm.1 uc008xqm.2 uc008xqm.3 uc008xqm.4 
ENSMUST00000087234.3 Cyp2c66 ENSMUST00000087234.3 cytochrome P450, family 2, subfamily c, polypeptide 66 (from RefSeq NM_001011707.1) Cyp2c66 ENSMUST00000087234.1 ENSMUST00000087234.2 NM_001011707 Q5GLZ0 Q5GLZ0_MOUSE uc008hjw.1 uc008hjw.2 Belongs to the cytochrome P450 family. hematopoietic progenitor cell differentiation monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process drug binding testosterone 16-alpha-hydroxylase activity arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding caffeine oxidase activity exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc008hjw.1 uc008hjw.2 
ENSMUST00000087236.5 Cyp2c65 ENSMUST00000087236.5 cytochrome P450, family 2, subfamily c, polypeptide 65 (from RefSeq NM_028191.2) Cyp2c65 ENSMUST00000087236.1 ENSMUST00000087236.2 ENSMUST00000087236.3 ENSMUST00000087236.4 NM_028191 Q148B1 Q148B1_MOUSE uc008hjv.1 uc008hjv.2 uc008hjv.3 uc008hjv.4 Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process drug binding testosterone 16-alpha-hydroxylase activity arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding caffeine oxidase activity exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc008hjv.1 uc008hjv.2 uc008hjv.3 uc008hjv.4 
ENSMUST00000087241.7 Shisa3 ENSMUST00000087241.7 shisa family member 3 (from RefSeq NM_001033415.3) ENSMUST00000087241.1 ENSMUST00000087241.2 ENSMUST00000087241.3 ENSMUST00000087241.4 ENSMUST00000087241.5 ENSMUST00000087241.6 NM_001033415 Q3UPR0 Q8C5V3 SHSA3_MOUSE uc008xpy.1 uc008xpy.2 uc008xpy.3 uc008xpy.4 Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Endoplasmic reticulum membrane ; Single-pass type I membrane protein At 8.5 dpc, expressed in the foregut. At 9.5 dpc, expressed in the ventral mesencephalon and rhombencephalon. At 12.5 dpc, expressed in ventral midbrain, myotome and kidney. Mutants exhibited no phenotype in either head development or somitogenesis. Belongs to the shisa family. endoplasmic reticulum endoplasmic reticulum membrane multicellular organism development membrane integral component of membrane uc008xpy.1 uc008xpy.2 uc008xpy.3 uc008xpy.4 
ENSMUST00000087258.10 Tro ENSMUST00000087258.10 trophinin, transcript variant 4 (from RefSeq NM_001290770.1) ENSMUST00000087258.1 ENSMUST00000087258.2 ENSMUST00000087258.3 ENSMUST00000087258.4 ENSMUST00000087258.5 ENSMUST00000087258.6 ENSMUST00000087258.7 ENSMUST00000087258.8 ENSMUST00000087258.9 NM_001290770 Q6DIC6 Q6DIC6_MOUSE Tro uc057atd.1 uc057atd.2 uc057atd.3 molecular_function nucleus cytoplasm negative regulation of cell growth uc057atd.1 uc057atd.2 uc057atd.3 
ENSMUST00000087268.7 Abca12 ENSMUST00000087268.7 ATP-binding cassette, sub-family A member 12 (from RefSeq NM_175210.3) ABCAC_MOUSE Abca12 E9Q876 ENSMUST00000087268.1 ENSMUST00000087268.2 ENSMUST00000087268.3 ENSMUST00000087268.4 ENSMUST00000087268.5 ENSMUST00000087268.6 NM_175210 uc011wmq.1 uc011wmq.2 uc011wmq.3 Transports lipids such as glucosylceramides from the outer to the inner leaflet of lamellar granules (LGs) membrane, whereby the lipids are finally transported to the keratinocyte periphery via the trans-Golgi network and LGs and released to the apical surface of the granular keratinocytes to form lipid lamellae in the stratum corneum of the epidermis, which is essential for skin barrier function (PubMed:18957418, PubMed:27551807, PubMed:24293640, PubMed:20489143, PubMed:18802465). In the meantime, participates in the transport of the lamellar granules-associated proteolytic enzymes, in turn regulates desquamation and keratinocyte differentiation (PubMed:27551807, PubMed:20489143). Furthermore, is essential for the regulation of cellular cholesterol homeostasis by regulating ABCA1-dependent cholesterol efflux from macrophages through interaction with NR1H2 and ABCA1 (PubMed:18802465, PubMed:23931754). Plays pleiotropic roles in regulating glucose stimulated insulin secretion from beta cells, regulating the morphology and fusion of insulin granules, lipid raft abundance and the actin cytoskeleton (PubMed:32072744). Also involved in lung surfactant biogenesis (PubMed:18632686). Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence=; Reaction=ATP + beta-D-glucosylceramide(in) + H2O = ADP + beta-D- glucosylceramide(out) + H(+) + phosphate; Xref=Rhea:RHEA:66660, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:83264, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66661; Evidence=; Interacts with NR1H2 and ABCA1; this interaction is required for ABCA1 localization to the cell surface and is necessary for its normal activity and stability. Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein Golgi apparatus membrane Note=Localizes in the limiting membrane of the lamellar granules (LGs). Trafficks from the Golgi apparatus to the lamellar granules (LGs) at the cell periphery in the uppermost granular layer keratinocytes where ABCA12-positive LGs fuse with the keratinocyte-cell membrane to secrete their lipid content to the extracellular space of the stratum corneum. Co-localizes through the Golgi apparatus to the cell periphery with glucosylceramide. Expressed in a number of other tissues besides skin, including heart, intestine, stomach, and kidney (PubMed:24293640). Expressed mainly in the granular layer of the skin (PubMed:18632686). Expressed in lung (PubMed:18632686). Expressed in alpha and beta cells of pancreatic islets (PubMed:32072744). At 18.5 dpc highly expressed in the epidermis, and weakly in the stomach. Up-regulated during barrier recovery. Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Homozygous knockout mice for Abca12 are born with a thickened epidermis and die shortly after birth, as water rapidly evaporates from their skin (PubMed:18957418). In a mouse model for harlequin ichthyosis (HI), homozygous knockout mice are smaller and die within a few hours and their entire body are covered of erythematous skin, making their skin less flexible. The entire skin surface is covered with thick scales and some mice develop skin fissures and eversions of the lips (eclabium). At 18.5 dpc, fetuses develop taut and shiny skin without normal skin folds and show contractures of the limbs. The lungs of the present model mice show signs of alveolar collapse (PubMed:18632686). Belongs to the ABC transporter superfamily. ABCA family. nucleotide binding receptor binding lipid transporter activity protein binding ATP binding cytoplasm mitochondrial inner membrane cytosol plasma membrane lipid transport positive regulation of cholesterol efflux membrane integral component of membrane ATPase activity transmembrane transporter activity keratinocyte differentiation keratinization secretion by cell phospholipid efflux apolipoprotein A-I receptor binding ceramide transport ATPase activity, coupled to transmembrane movement of substances surfactant homeostasis intracellular membrane-bounded organelle regulated exocytosis lung alveolus development transmembrane transport lipid homeostasis establishment of skin barrier protein localization to plasma membrane epidermal lamellar body positive regulation of protein localization to cell surface uc011wmq.1 uc011wmq.2 uc011wmq.3 
ENSMUST00000087285.5 Foxd3 ENSMUST00000087285.5 forkhead box D3 (from RefSeq NM_010425.3) A2BDY3 A2BDY3_MOUSE ENSMUST00000087285.1 ENSMUST00000087285.2 ENSMUST00000087285.3 ENSMUST00000087285.4 Foxd3 NM_010425 uc008tuv.1 uc008tuv.2 uc008tuv.3 Nucleus negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc008tuv.1 uc008tuv.2 uc008tuv.3 
ENSMUST00000087315.14 Vars1 ENSMUST00000087315.14 valyl-tRNA synthetase 1, transcript variant 1 (from RefSeq NM_011690.4) Bat6 ENSMUST00000087315.1 ENSMUST00000087315.10 ENSMUST00000087315.11 ENSMUST00000087315.12 ENSMUST00000087315.13 ENSMUST00000087315.2 ENSMUST00000087315.3 ENSMUST00000087315.4 ENSMUST00000087315.5 ENSMUST00000087315.6 ENSMUST00000087315.7 ENSMUST00000087315.8 ENSMUST00000087315.9 G7a NM_011690 Q9QUN2 Q9Z1Q9 SYVC_MOUSE Vars Vars2 uc008cez.1 uc008cez.2 uc008cez.3 uc008cez.4 Reaction=ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl- tRNA(Val); Xref=Rhea:RHEA:10704, Rhea:RHEA-COMP:9672, Rhea:RHEA- COMP:9708, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57762, ChEBI:CHEBI:78442, ChEBI:CHEBI:78537, ChEBI:CHEBI:456215; EC=6.1.1.9; Can be regulated by protein kinase C-dependent phosphorylation. Forms high-molecular-mass aggregates with elongation factor 1. Belongs to the class-I aminoacyl-tRNA synthetase family. nucleotide binding aminoacyl-tRNA editing activity aminoacyl-tRNA ligase activity valine-tRNA ligase activity ATP binding cytoplasm mitochondrion cytosol translation tRNA aminoacylation for protein translation valyl-tRNA aminoacylation ligase activity uc008cez.1 uc008cez.2 uc008cez.3 uc008cez.4 
ENSMUST00000087316.6 Capn6 ENSMUST00000087316.6 calpain 6 (from RefSeq NM_007603.3) CAN6_MOUSE Capa6 ENSMUST00000087316.1 ENSMUST00000087316.2 ENSMUST00000087316.3 ENSMUST00000087316.4 ENSMUST00000087316.5 NM_007603 O35646 Q3UM55 uc009umk.1 uc009umk.2 uc009umk.3 uc009umk.4 uc009umk.5 Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues. Interacts (via domain III) with microtubules. Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger). Cytoplasm, perinuclear region Cytoplasm, cytoskeleton, spindle At 10.5 dpc expressed in the mandibular arches, heart and limb buds. Up-regulated during the osteoclasogenic process. Inhibited by dexamethaxone during the osteoclasogenic process. Belongs to the peptidase C2 family. microtubule bundle formation calcium-dependent cysteine-type endopeptidase activity protein binding cytoplasm spindle cytosol cytoskeleton microtubule spindle microtubule proteolysis microtubule binding perinuclear region of cytoplasm regulation of cytoskeleton organization uc009umk.1 uc009umk.2 uc009umk.3 uc009umk.4 uc009umk.5 
ENSMUST00000087321.4 Ppp1r3c ENSMUST00000087321.4 protein phosphatase 1, regulatory subunit 3C (from RefSeq NM_016854.2) ENSMUST00000087321.1 ENSMUST00000087321.2 ENSMUST00000087321.3 NM_016854 O08541 PPR3C_MOUSE Ppp1r3c Ppp1r5 Q7TMB3 Q8BJW8 uc008hhs.1 uc008hhs.2 uc008hhs.3 uc008hhs.4 Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. Also interacts with EPM2A/laforin. The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase. Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner. Mice display embryonic lethality when homozygous. Heterozygotes display decreased protein levels, decreased glycogen accumulation and glycogen synthase activity, reduced insulin-stimulated glycogen synthesis and progressive age-dependent glucose intolerance. When Ppp1r3c is silenced in adults, they display decreased PP1 activity and glycogen accumulation, increased phosphorylation of glycogen phosphorylase, increased GLUT1 levels, increased glucose uptake and increased glycogen degradation. Sequence=AAB49689.1; Type=Erroneous initiation; Evidence=; carbohydrate metabolic process glycogen metabolic process glycogen biosynthetic process protein dephosphorylation protein targeting enzyme binding protein phosphatase binding glycogen granule intracellular membrane-bounded organelle [phosphorylase] phosphatase activity glycogen binding phosphoprotein phosphatase activity uc008hhs.1 uc008hhs.2 uc008hhs.3 uc008hhs.4 
ENSMUST00000087324.7 Pgm2 ENSMUST00000087324.7 phosphoglucomutase 2, transcript variant 1 (from RefSeq NM_025700.3) ENSMUST00000087324.1 ENSMUST00000087324.2 ENSMUST00000087324.3 ENSMUST00000087324.4 ENSMUST00000087324.5 ENSMUST00000087324.6 NM_025700 PGM2_MOUSE Pgm1 Pgm2 Q7TSV4 Q8K0P7 Q9CRS8 uc008xmi.1 uc008xmi.2 uc008xmi.3 uc008xmi.4 Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5- phosphopentoses. Catalyzes the interconversion of glucose-1-phosphate into glucose-6-phosphate but with a lower catalytic efficiency. In vitro, has also a low glucose 1,6-bisphosphate synthase activity which is most probably not physiologically relevant. Reaction=alpha-D-ribose 1-phosphate = D-ribose 5-phosphate; Xref=Rhea:RHEA:18793, ChEBI:CHEBI:57720, ChEBI:CHEBI:78346; EC=5.4.2.7; Evidence=; Reaction=2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5- phosphate; Xref=Rhea:RHEA:27658, ChEBI:CHEBI:57259, ChEBI:CHEBI:62877; EC=5.4.2.7; Evidence=; Reaction=alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate; Xref=Rhea:RHEA:23536, ChEBI:CHEBI:58225, ChEBI:CHEBI:58601; EC=5.4.2.2; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Cytoplasm, cytosol Highly expressed in lung, spleen and thymus. Expressed at lower levels in liver, brain, kidney, skeletal muscle, testis and heart. Belongs to the phosphohexose mutase family. There is a known reversal of the Pgm1 and Pgm2 nomenclature applied to mouse versus other vertebrates. The official name of this gene in mouse is Pgm1 but it is the ortholog of other vertebrate PGM2 genes. magnesium ion binding phosphoglucomutase activity cytoplasm carbohydrate metabolic process glucose metabolic process phosphopentomutase activity isomerase activity intramolecular transferase activity, phosphotransferases deoxyribose phosphate catabolic process metal ion binding organic substance metabolic process uc008xmi.1 uc008xmi.2 uc008xmi.3 uc008xmi.4 
ENSMUST00000087328.4 Hspa1a ENSMUST00000087328.4 heat shock protein 1A (from RefSeq NM_010479.2) ENSMUST00000087328.1 ENSMUST00000087328.2 ENSMUST00000087328.3 HS71A_MOUSE Hsp70-3 Hsp70A1 NM_010479 Q61696 Q61697 Q7TQD8 Q9QWJ5 uc008cep.1 uc008cep.2 uc008cep.3 Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co- chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone- mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation. Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle. Enhances STUB1- mediated SMAD3 ubiquitination and degradation and facilitates STUB1- mediated inhibition of TGF-beta signaling. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Component of the CatSper complex (By similarity). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2 (By similarity). Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed (By similarity). Interacts with METTL21A (By similarity). Interacts with DNAAF2 (PubMed:19052621). Interacts with TRIM5 (via B30.2/SPRY domain) (By similarity). Interacts with PRKN (By similarity). Interacts with FOXP3 (PubMed:23973223). Interacts with NOD2; the interaction enhances NOD2 stability (By similarity). Interacts with DNAJC9 (via J domain) (By similarity). Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome- dependent and caspase-dependent processes (By similarity). Interacts with RNF207 (via the C-terminus); this interaction additively increases KCNH2 expression (By similarity). Interacts with HSF1 (via transactivation domain); this interaction results in the inhibition of heat shock- and HSF1-induced transcriptional activity during the attenuation and recovery phase period of the heat shock response. Interacts with NAA10, HSP40, HSP90 and HDAC4. The acetylated form and the non-acetylated form interact with HOPX and STUB1 respectively. Interacts with NEDD1 and SMAD3. Interacts (via NBD) with BAG1, BAG2, BAG3 and HSPH1/HSP105. Interacts with DNAJC8 (By similarity). Interacts with NLRP12. Interacts with PGLYRP (PubMed:14585845). Cytoplasm Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Secreted Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide- binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins. In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress. Belongs to the heat shock protein 70 family. nucleotide binding telomere maintenance G-protein coupled receptor binding protease binding transcription corepressor activity receptor binding protein binding ATP binding nucleus cytoplasm mitochondrion centrosome centriole microtubule organizing center cytosol cytoskeleton plasma membrane DNA repair mRNA catabolic process protein folding response to unfolded protein lysosomal transport negative regulation of cell proliferation response to heat vesicle-mediated transport inclusion body aggresome basolateral plasma membrane apical plasma membrane nuclear speck ATPase activity enzyme binding negative regulation of cell growth heat shock protein binding denatured protein binding ubiquitin protein ligase binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process macromolecular complex cellular response to heat cellular response to unfolded protein protein refolding ATPase activity, coupled histone deacetylase binding protein binding involved in protein folding membrane raft protein N-terminus binding perinuclear region of cytoplasm NF-kappaB binding unfolded protein binding chaperone mediated protein folding requiring cofactor misfolded protein binding C3HC4-type RING finger domain binding positive regulation of microtubule nucleation negative regulation of transcription from RNA polymerase II promoter in response to stress disordered domain specific binding regulation of mitotic spindle assembly ribonucleoprotein complex COP9 signalosome uc008cep.1 uc008cep.2 uc008cep.3 
ENSMUST00000087333.9 Tmem164 ENSMUST00000087333.9 transmembrane protein 164, transcript variant 2 (from RefSeq NM_177592.4) ENSMUST00000087333.1 ENSMUST00000087333.2 ENSMUST00000087333.3 ENSMUST00000087333.4 ENSMUST00000087333.5 ENSMUST00000087333.6 ENSMUST00000087333.7 ENSMUST00000087333.8 NM_177592 Q6PHN7 TM164_MOUSE uc009ulx.1 uc009ulx.2 uc009ulx.3 uc009ulx.4 Positive regulator of ferroptosis. Selectively mediates ATG5- dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death. Membrane ; Multi-pass membrane protein Belongs to the TMEM164 family. molecular_function cellular_component biological_process membrane integral component of membrane uc009ulx.1 uc009ulx.2 uc009ulx.3 uc009ulx.4 
ENSMUST00000087351.9 Hnrnpa1 ENSMUST00000087351.9 heterogeneous nuclear ribonucleoprotein A1, transcript variant 1 (from RefSeq NM_010447.6) ENSMUST00000087351.1 ENSMUST00000087351.2 ENSMUST00000087351.3 ENSMUST00000087351.4 ENSMUST00000087351.5 ENSMUST00000087351.6 ENSMUST00000087351.7 ENSMUST00000087351.8 Fli-2 Hnrpa1 NM_010447 P49312 P97312 Q3V269 ROA1_MOUSE Tis uc007xxp.1 uc007xxp.2 uc007xxp.3 uc007xxp.4 Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins. Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SEPT6. Interacts with C9orf72. Interacts with KHDRBS1. Interacts with UBQLN2 (By similarity). Interacts with PPIA/CYPA (By similarity). Nucleus Cytoplasm Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P49312-1; Sequence=Displayed; Name=Short; IsoId=P49312-2; Sequence=VSP_005825; Sumoylated. alternative mRNA splicing, via spliceosome nucleic acid binding single-stranded DNA binding RNA binding mRNA binding nucleus nucleoplasm spliceosomal complex cytoplasm mRNA processing RNA splicing miRNA binding mRNA transport nuclear export nuclear import cellular response to sodium arsenite ribonucleoprotein complex uc007xxp.1 uc007xxp.2 uc007xxp.3 uc007xxp.4 
ENSMUST00000087357.5 Ifit1bl2 ENSMUST00000087357.5 interferon induced protein with tetratricopeptide repeats 1B like 2, transcript variant 1 (from RefSeq NM_053217.3) 2010002M12Rik ENSMUST00000087357.1 ENSMUST00000087357.2 ENSMUST00000087357.3 ENSMUST00000087357.4 Ifit1bl2 NM_053217 Q3U687 Q3U687_MOUSE uc008hgs.1 uc008hgs.2 uc008hgs.3 Belongs to the IFIT family. RNA binding cytoplasm cytosol response to virus regulation of defense response to virus defense response to virus cellular response to type I interferon cellular response to exogenous dsRNA uc008hgs.1 uc008hgs.2 uc008hgs.3 
ENSMUST00000087359.6 Cryge ENSMUST00000087359.6 crystallin, gamma E, transcript variant 1 (from RefSeq NM_007777.4) CRGE_MOUSE ENSMUST00000087359.1 ENSMUST00000087359.2 ENSMUST00000087359.3 ENSMUST00000087359.4 ENSMUST00000087359.5 NM_007777 O89028 P26999 Q03740 Q9CXK5 uc007bhf.1 uc007bhf.2 uc007bhf.3 Crystallins are the dominant structural components of the vertebrate eye lens. Detected in the superior olivary complex of the auditory hindbrain. In the embryo, expressed by day 12 of gestation. Maximum levels are found at day 30-40 followed by a rapid decline. Has a two-domain beta-structure, folded into four very similar Greek key motifs. There are six different gamma crystallins identified in mouse lens. Belongs to the beta/gamma-crystallin family. eye development lens development in camera-type eye structural constituent of eye lens visual perception uc007bhf.1 uc007bhf.2 uc007bhf.3 
ENSMUST00000087366.11 Creb1 ENSMUST00000087366.11 cAMP responsive element binding protein 1, transcript variant A (from RefSeq NM_133828.2) Creb1 ENSMUST00000087366.1 ENSMUST00000087366.10 ENSMUST00000087366.2 ENSMUST00000087366.3 ENSMUST00000087366.4 ENSMUST00000087366.5 ENSMUST00000087366.6 ENSMUST00000087366.7 ENSMUST00000087366.8 ENSMUST00000087366.9 NM_133828 Q543W0 Q543W0_MOUSE uc007bgs.1 uc007bgs.2 uc007bgs.3 Nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated uc007bgs.1 uc007bgs.2 uc007bgs.3 
ENSMUST00000087374.10 Adam23 ENSMUST00000087374.10 a disintegrin and metallopeptidase domain 23 (from RefSeq NM_011780.3) ADA23_MOUSE ENSMUST00000087374.1 ENSMUST00000087374.2 ENSMUST00000087374.3 ENSMUST00000087374.4 ENSMUST00000087374.5 ENSMUST00000087374.6 ENSMUST00000087374.7 ENSMUST00000087374.8 ENSMUST00000087374.9 Mdc3 NM_011780 Q6QDY9 Q6QDZ0 Q8CC33 Q9R1V7 uc007bgg.1 uc007bgg.2 uc007bgg.3 uc007bgg.4 This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an inactive metalloprotease and disintegrin domains. Transgenic disruption of this gene in mice results in postnatal neurological defects including tremor and ataxia resulting in death by 2 weeks of age. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB009673.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). Can bind to LGI1 and LGI4. Cell membrane ; Single-pass type I membrane protein [Isoform Gamma]: Secreted. Event=Alternative splicing; Named isoforms=4; Name=Alpha; IsoId=Q9R1V7-1; Sequence=Displayed; Name=Beta; IsoId=Q9R1V7-2; Sequence=VSP_012050; Name=Gamma; IsoId=Q9R1V7-3; Sequence=VSP_012049; Name=Delta; IsoId=Q9R1V7-4; Sequence=VSP_012047, VSP_012048; Brain specific. On 15 dpc embryo the level of isoform Gamma exceeded that of isoform Alpha and isoform Beta and decreased after birth. On P10 post neonatal, the level of isoform Gamma is undetectable and isoform Alpha and isoform Beta are expressed again. metalloendopeptidase activity protein binding extracellular region plasma membrane proteolysis cell adhesion metallopeptidase activity membrane integral component of membrane glutamatergic synapse integral component of presynaptic membrane cellular response to leukemia inhibitory factor uc007bgg.1 uc007bgg.2 uc007bgg.3 uc007bgg.4 
ENSMUST00000087401.12 Morc4 ENSMUST00000087401.12 microrchidia 4, transcript variant A (from RefSeq NM_001193309.1) A2RTG5 ENSMUST00000087401.1 ENSMUST00000087401.10 ENSMUST00000087401.11 ENSMUST00000087401.2 ENSMUST00000087401.3 ENSMUST00000087401.4 ENSMUST00000087401.5 ENSMUST00000087401.6 ENSMUST00000087401.7 ENSMUST00000087401.8 ENSMUST00000087401.9 MORC4_MOUSE NM_001193309 Q4KMM6 Q8BMD7 Q8BX95 Q9CS96 Zcwcc2 uc009ukn.1 uc009ukn.2 uc009ukn.3 uc009ukn.4 Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (By similarity). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BMD7-1; Sequence=Displayed; Name=2; IsoId=Q8BMD7-2; Sequence=VSP_015277, VSP_015278; The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3. Sequence=AAH98483.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=AAH98483.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAB30759.1; Type=Erroneous initiation; Evidence=; molecular_function nucleus nucleoplasm biological_process zinc ion binding metal ion binding uc009ukn.1 uc009ukn.2 uc009ukn.3 uc009ukn.4 
ENSMUST00000087435.7 Bmpr2 ENSMUST00000087435.7 bone morphogenetic protein receptor type 2 (from RefSeq NM_007561.4) BMPR2_MOUSE ENSMUST00000087435.1 ENSMUST00000087435.2 ENSMUST00000087435.3 ENSMUST00000087435.4 ENSMUST00000087435.5 ENSMUST00000087435.6 NM_007561 O35607 uc007bdz.1 uc007bdz.2 uc007bdz.3 uc007bdz.4 This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF003942.1, U78048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (By similarity). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6 (PubMed:23527555). Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA- COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Interacts with GDF5 (By similarity). Interacts with BMP4 (By similarity). Interacts with SCUBE3 (By similarity). Interacts with TSC22D1/TSC-22 (By similarity). O35607; P0C605: Prkg1; NbExp=4; IntAct=EBI-527224, EBI-6991999; Cell membrane ; Single-pass type I membrane protein. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. nucleotide binding mesoderm formation maternal placenta development endothelial cell proliferation positive regulation of endothelial cell proliferation lymphangiogenesis blood vessel remodeling chondrocyte development negative regulation of systemic arterial blood pressure outflow tract septum morphogenesis outflow tract morphogenesis aortic valve development pulmonary valve development mitral valve morphogenesis tricuspid valve morphogenesis endocardial cushion development negative regulation of cell proliferation involved in heart valve morphogenesis protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type II protein binding ATP binding nucleoplasm cytoplasm plasma membrane integral component of plasma membrane caveola cell-cell adherens junction transcription from RNA polymerase II promoter protein phosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway pattern specification process brain development cellular response to starvation basal plasma membrane anterior/posterior pattern specification cell surface positive regulation of endothelial cell migration positive regulation of epithelial cell migration positive regulation of pathway-restricted SMAD protein phosphorylation postsynaptic density regulation of lung blood pressure membrane integral component of membrane kinase activity phosphorylation apical plasma membrane transferase activity growth factor binding proteoglycan biosynthetic process negative regulation of cell growth dendrite positive regulation of bone mineralization BMP signaling pathway positive regulation of BMP signaling pathway BMP binding regulation of cell proliferation neuronal cell body receptor complex cadherin binding positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of vasoconstriction positive regulation of transcription from RNA polymerase II promoter SMAD binding metal ion binding lung alveolus development positive regulation of axon extension involved in axon guidance retina development in camera-type eye limb development endochondral bone morphogenesis ventricular septum morphogenesis atrial septum morphogenesis lymphatic endothelial cell differentiation artery development venous blood vessel development positive regulation of cartilage development retina vasculature development in camera-type eye pharyngeal arch artery morphogenesis cellular response to BMP stimulus endothelial cell apoptotic process BMP receptor activity negative regulation of chondrocyte proliferation semi-lunar valve development protein tyrosine kinase binding negative regulation of DNA biosynthetic process atrioventricular valve morphogenesis cardiac muscle tissue development uc007bdz.1 uc007bdz.2 uc007bdz.3 uc007bdz.4 
ENSMUST00000087445.7 Tuba3b ENSMUST00000087445.7 tubulin, alpha 3B (from RefSeq NM_009449.3) ENSMUST00000087445.1 ENSMUST00000087445.2 ENSMUST00000087445.3 ENSMUST00000087445.4 ENSMUST00000087445.5 ENSMUST00000087445.6 NM_009449 Q5FW91 Q5FW91_MOUSE Tuba3a uc009erq.1 uc009erq.2 uc009erq.3 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Belongs to the tubulin family. nucleotide binding GTPase activity structural constituent of cytoskeleton GTP binding cytoplasm cytoskeleton microtubule cytoskeleton organization microtubule-based process uc009erq.1 uc009erq.2 uc009erq.3 
ENSMUST00000087475.11 Tmem237 ENSMUST00000087475.11 transmembrane protein 237, transcript variant 2 (from RefSeq NM_001037812.3) Als2cr4 B2RVK7 ENSMUST00000087475.1 ENSMUST00000087475.10 ENSMUST00000087475.2 ENSMUST00000087475.3 ENSMUST00000087475.4 ENSMUST00000087475.5 ENSMUST00000087475.6 ENSMUST00000087475.7 ENSMUST00000087475.8 ENSMUST00000087475.9 NM_001037812 Q3TIS2 Q3V0J1 TM237_MOUSE uc007bdd.1 uc007bdd.2 uc007bdd.3 Component of the transition zone in primary cilia. Required for ciliogenesis. Part of the tectonic-like complex (also named B9 complex). Interacts with TMEM107. Membrane ; Multi-pass membrane protein Cell projection, cilium Note=Localizes at the proximal region of primary cilia were observed, consistent with localization to the transition zone. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3V0J1-1; Sequence=Displayed; Name=2; IsoId=Q3V0J1-2; Sequence=VSP_042384, VSP_042386; Name=3; IsoId=Q3V0J1-3; Sequence=VSP_042385, VSP_042386; Belongs to the TMEM237 family. molecular_function cilium membrane integral component of membrane cell projection organization regulation of Wnt signaling pathway ciliary transition zone cell projection cilium assembly uc007bdd.1 uc007bdd.2 uc007bdd.3 
ENSMUST00000087511.10 Tmem128 ENSMUST00000087511.10 transmembrane protein 128, transcript variant 1 (from RefSeq NM_025480.4) ENSMUST00000087511.1 ENSMUST00000087511.2 ENSMUST00000087511.3 ENSMUST00000087511.4 ENSMUST00000087511.5 ENSMUST00000087511.6 ENSMUST00000087511.7 ENSMUST00000087511.8 ENSMUST00000087511.9 NM_025480 Q8BNQ8 Q9CYX2 Q9CZB9 TM128_MOUSE uc008xgk.1 uc008xgk.2 uc008xgk.3 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc008xgk.1 uc008xgk.2 uc008xgk.3 
ENSMUST00000087514.9 Lyar ENSMUST00000087514.9 Ly1 antibody reactive clone, transcript variant 1 (from RefSeq NM_025281.4) ENSMUST00000087514.1 ENSMUST00000087514.2 ENSMUST00000087514.3 ENSMUST00000087514.4 ENSMUST00000087514.5 ENSMUST00000087514.6 ENSMUST00000087514.7 ENSMUST00000087514.8 LYAR_MOUSE NM_025281 Q08288 Q9D9X2 uc008xgh.1 uc008xgh.2 uc008xgh.3 uc008xgh.4 Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). Also acts at the level of transcription regulation. Along with PRMT5, binds embryonic globin promoter (By similarity). Represses the expression of embryonic globin Hbb-y gene (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41 (By similarity). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (By similarity). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity). In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (By similarity). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (PubMed:25735755). Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (PubMed:19489080). Interacts with PRMT5; this interaction is direct (By similarity). Interacts with GNL2 and RPL23A (By similarity). Interacts with nucleolin/NCL; this interaction is direct (PubMed:19489080, PubMed:23212345). Interacts with phosphorylated IRF3; this interaction impairs IRF3 DNA-binding activity (By similarity). Nucleus, nucleolus toplasm Cell projection, cilium, photoreceptor outer segment Note=Component of pre-ribosomal particles, including pre-40S, pre-60S and pre-90S (By similarity). Associated with cytoplasmic ribosomes, but not polysomes, as a component of the 60S subunit (PubMed:24990247). In the retina, predominantly expressed in photoreceptor outer segments (PubMed:25735755). In the nucleolus, colocalizes with nucleolin/NCL, therefore may reside in the dense fibrillar component (DFC) (PubMed:19489080). Predominantly expressed in testis, in germ cells, and at a moderate level in spleen, liver and lung (at protein level) (PubMed:19489080, PubMed:23212345, PubMed:24990247). Very high levels in spermatogonia, spermatocytes and round spermatids, but not in testicular sperm and mature sperm (at protein level) (PubMed:20339383, PubMed:23212345, PubMed:24990247). Expressed in ovary (PubMed:20339383). Expressed in the retina, including in photoreceptor outer segments (at protein level) (PubMed:25735755). Expressed in undifferentiated embryonic stem cells (PubMed:19489080, PubMed:23212345). Expressed in testis and ovary at 15.5 dpc (PubMed:20339383). May be differentially expressed during spermatogenesis. Detected first at P12, the early stage of spermatogenesis. Levels considerably increase at P16, corresponding to the development of pachytene spermatocytes (PubMed:23212345). The N-terminal zinc-finger domains are required for the appropriate production of 28S rRNA and the formation of pre-60S particles. No visible phenotype. Mutant mice are fully fertile and show intact spermatogenesis. negative regulation of transcription from RNA polymerase II promoter photoreceptor outer segment DNA binding nucleus nucleolus cytoplasm rRNA processing cell projection metal ion binding erythrocyte development positive regulation of phagocytosis uc008xgh.1 uc008xgh.2 uc008xgh.3 uc008xgh.4 
ENSMUST00000087517.10 Dido1 ENSMUST00000087517.10 death inducer-obliterator 1, transcript variant 3 (from RefSeq NM_175551.5) A2AJ47 A2AJ48 B2RS46 DIDO1_MOUSE Datf1 Dio1 ENSMUST00000087517.1 ENSMUST00000087517.2 ENSMUST00000087517.3 ENSMUST00000087517.4 ENSMUST00000087517.5 ENSMUST00000087517.6 ENSMUST00000087517.7 ENSMUST00000087517.8 ENSMUST00000087517.9 NM_175551 Q05C59 Q3ZTP5 Q3ZTP6 Q4V9W1 Q6ZQD7 Q80V34 Q8BMD0 Q8BRG2 Q8C9B9 Q8CHR5 Q9WV00 uc008ojq.1 uc008ojq.2 uc008ojq.3 uc008ojq.4 This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. Required for early embryonic stem cell development (By similarity). Putative transcription factor, weakly pro-apoptotic when overexpressed. Interacts specifically (via PHD-type zinc finger) with histone H3 that is trimethylated at 'Lys-4' (H3K4me3), histone phosphorylation at 'Thr-3' or 'Thr-6' disrupts this binding and promotes translocation of DIDO1 from chromatin to the mitotic spindle during mitosis. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle Note=Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis (By similarity). Translocates to the nucleus after pro-apoptotic stimuli. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Dido3; IsoId=Q8C9B9-1; Sequence=Displayed; Name=2; Synonyms=Dido1; IsoId=Q8C9B9-2; Sequence=VSP_012363, VSP_012364; Name=3; Synonyms=Dido2; IsoId=Q8C9B9-3; Sequence=VSP_026606, VSP_026607; Ubiquitous. Expressed at intermediate levels. Up-regulated during apoptosis. The PHD-type zinc finger forms an aromatic cage around H3K4me3. Sequence=AAH44755.1; Type=Erroneous initiation; Evidence=; Sequence=BAC28053.1; Type=Erroneous initiation; Evidence=; Sequence=BAC97927.1; Type=Erroneous initiation; Evidence=; nucleus nucleoplasm cytoplasm spindle cytoskeleton transcription, DNA-templated apoptotic process metal ion binding apoptotic signaling pathway uc008ojq.1 uc008ojq.2 uc008ojq.3 uc008ojq.4 
ENSMUST00000087521.13 Nif3l1 ENSMUST00000087521.13 Ngg1 interacting factor 3-like 1 (S. pombe) (from RefSeq NM_022988.3) ENSMUST00000087521.1 ENSMUST00000087521.10 ENSMUST00000087521.11 ENSMUST00000087521.12 ENSMUST00000087521.2 ENSMUST00000087521.3 ENSMUST00000087521.4 ENSMUST00000087521.5 ENSMUST00000087521.6 ENSMUST00000087521.7 ENSMUST00000087521.8 ENSMUST00000087521.9 NIF3L_MOUSE NM_022988 Nif3l1 Q6P1B7 Q9D098 Q9EQ80 uc007bbz.1 uc007bbz.2 uc007bbz.3 This gene is a member of the NGG1-interacting factor 3-like superfamily of transcriptional regulators and is ubiquitously expressed throughout embryonic development. The encoded protein interacts with a component of the constitutive photomorphogenesis 9 signalosome, and functions as a transcriptional corepressor of genes involved in neuronal differentiation. This gene is highly conserved from bacteria to human. [provided by RefSeq, Sep 2016]. ##Evidence-Data-START## Transcript exon combination :: AF284439.1, AK131631.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation. Homodimer (By similarity). Interacts with COPS2 (PubMed:12522100). Interacts with THOC7 (PubMed:12951069). Cytoplasm Nucleus Note=Interaction with COPS2 may regulate localization to the nucleus. Ubiquitous. Detected in all tissues tested with higher expression in cerebellum, heart and kidney and to a lower level in cerebrum, lung, liver, spleen and muscle. Expressed in the developing brain from 10.5 dpc until 14.5 dpc. The expression decreases after 16.5 dpc, but an up- regulation is observed at P5 and the expression remains constant thereafter. Belongs to the GTP cyclohydrolase I type 2/NIF3 family. protein binding nucleus cytoplasm mitochondrion transcription factor binding neuron differentiation identical protein binding positive regulation of transcription, DNA-templated negative regulation of nucleic acid-templated transcription uc007bbz.1 uc007bbz.2 uc007bbz.3 
ENSMUST00000087527.11 Abcc9 ENSMUST00000087527.11 ATP-binding cassette, sub-family C member 9, transcript variant 2 (from RefSeq NM_021041.3) ABCC9_MOUSE ENSMUST00000087527.1 ENSMUST00000087527.10 ENSMUST00000087527.2 ENSMUST00000087527.3 ENSMUST00000087527.4 ENSMUST00000087527.5 ENSMUST00000087527.6 ENSMUST00000087527.7 ENSMUST00000087527.8 ENSMUST00000087527.9 NM_021041 O08902 O08920 P70170 P70171 Sur2 uc009epm.1 uc009epm.2 uc009epm.3 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Interacts with KCNJ11. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=SUR2A; IsoId=P70170-1; Sequence=Displayed; Name=SUR2B; IsoId=P70170-2; Sequence=VSP_000060; Name=SUR2C; IsoId=P70170-3; Sequence=VSP_000059; Isoforms SUR2A and SUR2B are found in cerebellum, eye, atrium, ventricle, urinary bladder and skeletal muscle. Isoform SUR2B is also found in forebrain, liver, lung, pancreas, kidney, spleen, stomach, small intestine, colon, uterus, ovary and fat tissue. Isoform SUR2C is expressed exclusively in the heart. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. nucleotide binding acrosomal vesicle ATP binding mitochondrion plasma membrane potassium ion transport drug binding sulfonylurea receptor activity ATP-sensitive potassium channel complex potassium channel regulator activity membrane integral component of membrane ATPase activity syntaxin binding sarcomere T-tubule sarcolemma ATPase activity, coupled to transmembrane movement of substances identical protein binding ion channel binding defense response to virus transmembrane transport potassium ion transmembrane transport potassium ion import across plasma membrane potassium channel activity uc009epm.1 uc009epm.2 uc009epm.3 
ENSMUST00000087541.12 Trmt2b ENSMUST00000087541.12 TRM2 tRNA methyltransferase 2B, transcript variant 2 (from RefSeq NM_172540.2) ENSMUST00000087541.1 ENSMUST00000087541.10 ENSMUST00000087541.11 ENSMUST00000087541.2 ENSMUST00000087541.3 ENSMUST00000087541.4 ENSMUST00000087541.5 ENSMUST00000087541.6 ENSMUST00000087541.7 ENSMUST00000087541.8 ENSMUST00000087541.9 NM_172540 Q8BQJ6 Q8CE55 TRM2B_MOUSE Trmt2b uc009ufq.1 uc009ufq.2 uc009ufq.3 uc009ufq.4 Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and 12S rRNA (PubMed:31736397). Catalyzes the methylation of uridine at position 54 (m5U54) in all tRNAs (PubMed:31736397). Specifically methylates the uridine in position 425 of 12S rRNA (m5U425) (PubMed:31736397). Does not affect RNA stability or mitochondrial translation (By similarity). Reaction=S-adenosyl-L-methionine + uridine(54) in tRNA = 5- methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42712, Rhea:RHEA-COMP:10167, Rhea:RHEA-COMP:10193, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65315, ChEBI:CHEBI:74447; EC=2.1.1.35; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42713; Evidence=; Reaction=a uridine in 12S rRNA + S-adenosyl-L-methionine = a 5- methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:69859, Rhea:RHEA-COMP:17791, Rhea:RHEA-COMP:17792, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65315, ChEBI:CHEBI:74447; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69860; Evidence=; Mitochondrion matrix Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RNA methylation mitochondrion RNA processing tRNA processing biological_process methyltransferase activity RNA methyltransferase activity transferase activity S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity methylation uc009ufq.1 uc009ufq.2 uc009ufq.3 uc009ufq.4 
ENSMUST00000087543.5 B3galt4 ENSMUST00000087543.5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 (from RefSeq NM_019420.2) B3GT4_MOUSE B3galt4 ENSMUST00000087543.1 ENSMUST00000087543.2 ENSMUST00000087543.3 ENSMUST00000087543.4 NM_019420 Q91VC1 Q920U8 Q920U9 Q9Z0F0 uc008caj.1 uc008caj.2 uc008caj.3 uc008caj.4 Involved in GM1/GD1B/GA1 ganglioside biosynthesis. Reaction=a ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GM1 (d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:16773, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:71502, ChEBI:CHEBI:77709; EC=2.4.1.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16774; Evidence=; Reaction=a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + H(+) + UDP; Xref=Rhea:RHEA:48280, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:79218, ChEBI:CHEBI:82639; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48281; Evidence=; Reaction=a ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GD1b (d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:47568, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:78542, ChEBI:CHEBI:87785; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47569; Evidence=; Reaction=a ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GA1 (d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:41960, ChEBI:CHEBI:15378, ChEBI:CHEBI:27731, ChEBI:CHEBI:27938, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41961; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein Expressed in heart, brain, spleen, kidney, lung and testis. First expressed at embryonic day 3. Maintained at high levels between days 4 and 7 and declines thereafter to stabilize at low levels after day 10. Belongs to the glycosyltransferase 31 family. Name=Functional Glycomics Gateway - GTase; Note=b3GalT4; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_457"; Golgi membrane ganglioside biosynthetic process endoplasmic reticulum Golgi apparatus protein glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups ganglioside galactosyltransferase activity uc008caj.1 uc008caj.2 uc008caj.3 uc008caj.4 
ENSMUST00000087556.7 Smc5 ENSMUST00000087556.7 structural maintenance of chromosomes 5, transcript variant 4 (from RefSeq NM_001426152.1) ENSMUST00000087556.1 ENSMUST00000087556.2 ENSMUST00000087556.3 ENSMUST00000087556.4 ENSMUST00000087556.5 ENSMUST00000087556.6 Kiaa0594 NM_001426152 Q80TW7 Q8CG46 Q8CHX5 Q922K3 SMC5_MOUSE Smc5l1 uc008hab.1 uc008hab.2 uc008hab.3 uc008hab.4 Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity). Forms a heterodimer with SMC6. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. Interacts with NSMCE2. Interacts with SLF2; this interaction induces an association of the SLF1-SLF2 complex with the SMC5-SMC6 complex. Interacts with RAD18; this interaction is increased in a SLF1 or SLF2-dependent manner. Nucleus romosome Nucleus, PML body Chromosome, telomere Note=Colocalizes with SMC6 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (PubMed:11408570). Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines. Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double- strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CG46-1; Sequence=Displayed; Name=2; IsoId=Q8CG46-2; Sequence=VSP_022251, VSP_022252; Expressed in testis but not ovary. Expressed in ovary and testis at 15.5 dpc. The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC6, forming a V-shaped heterodimer. Sumoylated. Ubiquitinated. Belongs to the SMC family. SMC5 subfamily. Sequence=AAH07174.1; Type=Erroneous initiation; Evidence=; nucleotide binding telomere maintenance via recombination double-strand break repair via homologous recombination chromosome, telomeric region sex chromosome molecular_function ATP binding nucleus chromosome DNA repair DNA recombination cellular response to DNA damage stimulus cell cycle sister chromatid cohesion PML body nuclear speck cell junction Smc5-Smc6 complex positive regulation of maintenance of mitotic sister chromatid cohesion interchromatin granule site of double-strand break cell division positive regulation of chromosome segregation cellular senescence uc008hab.1 uc008hab.2 uc008hab.3 uc008hab.4 
ENSMUST00000087557.12 Tspan6 ENSMUST00000087557.12 tetraspanin 6 (from RefSeq NM_019656.3) ENSMUST00000087557.1 ENSMUST00000087557.10 ENSMUST00000087557.11 ENSMUST00000087557.2 ENSMUST00000087557.3 ENSMUST00000087557.4 ENSMUST00000087557.5 ENSMUST00000087557.6 ENSMUST00000087557.7 ENSMUST00000087557.8 ENSMUST00000087557.9 NM_019656 Q99L96 Q99L96_MOUSE Tm4sf6 Tspan6 uc009ufa.1 uc009ufa.2 uc009ufa.3 Membrane ulti-pass membrane protein Belongs to the tetraspanin (TM4SF) family. membrane integral component of membrane negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway negative regulation of NIK/NF-kappaB signaling uc009ufa.1 uc009ufa.2 uc009ufa.3 
ENSMUST00000087576.12 Trpm3 ENSMUST00000087576.12 transient receptor potential cation channel, subfamily M, member 3, transcript variant 2 (from RefSeq NM_001035240.3) ENSMUST00000087576.1 ENSMUST00000087576.10 ENSMUST00000087576.11 ENSMUST00000087576.2 ENSMUST00000087576.3 ENSMUST00000087576.4 ENSMUST00000087576.5 ENSMUST00000087576.6 ENSMUST00000087576.7 ENSMUST00000087576.8 ENSMUST00000087576.9 NM_001035240 Q5F4S9 Q5F4S9_MOUSE Trpm3 uc008gzj.1 uc008gzj.2 uc008gzj.3 uc008gzj.4 Membrane ; Multi- pass membrane protein ion channel activity calcium activated cation channel activity cation channel activity ion transport cation transport membrane integral component of membrane detection of temperature stimulus ion transmembrane transport sensory perception of temperature stimulus protein tetramerization transmembrane transport cation transmembrane transport uc008gzj.1 uc008gzj.2 uc008gzj.3 uc008gzj.4 
ENSMUST00000087585.10 Boll ENSMUST00000087585.10 boule homolog, RNA binding protein, transcript variant 1 (from RefSeq NM_029267.5) BOLL_MOUSE Boll Boule E9QPQ9 ENSMUST00000087585.1 ENSMUST00000087585.2 ENSMUST00000087585.3 ENSMUST00000087585.4 ENSMUST00000087585.5 ENSMUST00000087585.6 ENSMUST00000087585.7 ENSMUST00000087585.8 ENSMUST00000087585.9 NM_029267 Q924M5 Q9D4V2 uc007bal.1 uc007bal.2 uc007bal.3 Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity). Interacts with DAZ1 and DAZL. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=3; IsoId=Q924M5-3; Sequence=Displayed; Name=2; IsoId=Q924M5-2; Sequence=VSP_061272, VSP_061273; Testis specific. Not expressed in early embryos, primoridal germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis. First expressed in stage III spermatocytes and peaks in late pachytene or diplotene stage spermatocytes. Expressed in secondary spermatocytes and early spermatids, then decreases until it is undetectable in spermatids. Belongs to the RRM DAZ family. nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding cytoplasm regulation of translation multicellular organism development spermatogenesis translation activator activity cell differentiation positive regulation of translational initiation meiotic cell cycle 3'-UTR-mediated mRNA stabilization uc007bal.1 uc007bal.2 uc007bal.3 
ENSMUST00000087588.4 Gm17080 ENSMUST00000087588.4 Gm17080 (from geneSymbol) ENSMUST00000087588.1 ENSMUST00000087588.2 ENSMUST00000087588.3 uc289lij.1 uc289lij.2 uc289lij.1 uc289lij.2 
ENSMUST00000087600.10 Gda ENSMUST00000087600.10 guanine deaminase (from RefSeq NM_010266.2) ENSMUST00000087600.1 ENSMUST00000087600.2 ENSMUST00000087600.3 ENSMUST00000087600.4 ENSMUST00000087600.5 ENSMUST00000087600.6 ENSMUST00000087600.7 ENSMUST00000087600.8 ENSMUST00000087600.9 GUAD_MOUSE Gda NM_010266 Q9R111 uc008gyx.1 uc008gyx.2 uc008gyx.3 Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Reaction=guanine + H(+) + H2O = NH4(+) + xanthine; Xref=Rhea:RHEA:14665, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16235, ChEBI:CHEBI:17712, ChEBI:CHEBI:28938; EC=3.5.4.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14666; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Kinetic parameters: KM=22.7 uM for guanine ; Purine metabolism; guanine degradation; xanthine from guanine: step 1/1. Homodimer. Q9R111; Q62108: Dlg4; NbExp=6; IntAct=EBI-2308876, EBI-300895; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. protein binding guanine catabolic process zinc ion binding guanine deaminase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds positive regulation of microtubule polymerization guanine metabolic process metal ion binding uc008gyx.1 uc008gyx.2 uc008gyx.3 
ENSMUST00000087605.13 Myo1f ENSMUST00000087605.13 myosin IF (from RefSeq NM_053214.2) ENSMUST00000087605.1 ENSMUST00000087605.10 ENSMUST00000087605.11 ENSMUST00000087605.12 ENSMUST00000087605.2 ENSMUST00000087605.3 ENSMUST00000087605.4 ENSMUST00000087605.5 ENSMUST00000087605.6 ENSMUST00000087605.7 ENSMUST00000087605.8 ENSMUST00000087605.9 Myo1f NM_053214 Q8CG29 Q8CG29_MOUSE myosin-1F-like protein uc008byu.1 uc008byu.2 uc008byu.3 uc008byu.4 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. nucleotide binding motor activity actin binding ATP binding myosin complex uc008byu.1 uc008byu.2 uc008byu.3 uc008byu.4 
ENSMUST00000087622.6 Plekha5 ENSMUST00000087622.6 pleckstrin homology domain containing, family A member 5 (from RefSeq NM_144920.3) E9Q6H8 E9Q6H8_MOUSE ENSMUST00000087622.1 ENSMUST00000087622.2 ENSMUST00000087622.3 ENSMUST00000087622.4 ENSMUST00000087622.5 NM_144920 Plekha5 uc009eob.1 uc009eob.2 uc009eob.3 nucleoplasm cytosol phosphatidylinositol-5-phosphate binding postsynaptic density phosphatidylinositol-3-phosphate binding reproductive system development phosphatidylinositol-4-phosphate binding phosphatidylinositol-3,5-bisphosphate binding glutamatergic synapse uc009eob.1 uc009eob.2 uc009eob.3 
ENSMUST00000087623.13 Adamts10 ENSMUST00000087623.13 ADAM metallopeptidase with thrombospondin type 1 motif 10, transcript variant 1 (from RefSeq NM_172619.4) ATS10_MOUSE ENSMUST00000087623.1 ENSMUST00000087623.10 ENSMUST00000087623.11 ENSMUST00000087623.12 ENSMUST00000087623.2 ENSMUST00000087623.3 ENSMUST00000087623.4 ENSMUST00000087623.5 ENSMUST00000087623.6 ENSMUST00000087623.7 ENSMUST00000087623.8 ENSMUST00000087623.9 NM_172619 P58459 Q497H1 Q78TI1 Q8CG28 uc008byp.1 uc008byp.2 uc008byp.3 uc008byp.4 This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate a functional, zinc-dependent metallopeptidase enzyme. [provided by RefSeq, Jul 2016]. Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Interacts with FBN1; this interaction promotes microfibrils assembly. Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P58459-1; Sequence=Displayed; Name=2; IsoId=P58459-2; Sequence=VSP_026109, VSP_026110; Name=3; IsoId=P58459-3; Sequence=VSP_026108, VSP_026111, VSP_026112; Widely expressed in adult tissues. Widely expressed throughout embryo development. Widespread expression in embryo until 12.5 days of gestation, after which it is then expressed in a more restricted fashion, with especially strong expression in developing lung, bone, and craniofacial region. The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2- G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3- glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). [Isoform 2]: May be due to intron retention. Sequence=AAI00559.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI00559.1; Type=Frameshift; Evidence=; Sequence=AAO17380.1; Type=Erroneous gene model prediction; Evidence=; microfibril metalloendopeptidase activity extracellular region proteolysis peptidase activity metallopeptidase activity hydrolase activity metal ion binding uc008byp.1 uc008byp.2 uc008byp.3 uc008byp.4 
ENSMUST00000087629.10 Htra3 ENSMUST00000087629.10 HtrA serine peptidase 3, transcript variant 1 (from RefSeq NM_030127.3) B2RRV0 ENSMUST00000087629.1 ENSMUST00000087629.2 ENSMUST00000087629.3 ENSMUST00000087629.4 ENSMUST00000087629.5 ENSMUST00000087629.6 ENSMUST00000087629.7 ENSMUST00000087629.8 ENSMUST00000087629.9 HTRA3_MOUSE NM_030127 Prsp Q6WLC5 Q6YDR0 Q9D236 Tasp uc008xea.1 uc008xea.2 uc008xea.3 uc008xea.4 Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF- beta family proteins possibly indirectly by degradation of these ECM proteoglycans (PubMed:15206957). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity). Homotrimer (By similarity). Interacts with MYH9 (By similarity). Interacts with TGFB1; the interaction inhibits TGFB- mediated signaling. Interacts with BMP4; the interaction inhibits BMP4- mediated signaling. Interacts with TGFB2 and GDF5. Secreted Note=Secretion increased during decidualization of endometrial stromal cells. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A, Long; IsoId=Q9D236-3; Sequence=Displayed; Name=2; Synonyms=B, Short; IsoId=Q9D236-4; Sequence=VSP_018128, VSP_018129; Name=3; IsoId=Q9D236-1; Sequence=VSP_018127; Highest level of isoform 1 in maternal part of the placenta, moderate level in heart, testis and ovary, low level in muscle and lung. High expression found in granulosa cells of the ovary. Expressed in bone matrix, particularly in articular chondrocytes. Very low level of isoform 2 expressed in placenta. Expressed in the bone matrix, particularly in articular chondrocytes. First expressed at 9.5 dpc. Levels then increase until 14.5 dpc after which they remain high until newborn. First detected in the eye at 10.5 dpc and then expressed in tissues associated with skeletal tissue. At 12.5 dpc expressed in the vertebral rudiments in the tail region and, in the developing eye, in lens epithelium. At adulthood, expression found in the ganglion cell layer and the inner nuclear layer of the retina. In the developing heart at 16.5 dpc, expressed in the endocardial cushion. In the trachea at this stage, in outer layers and in the aorta, in adventitia. Up-regulated during early pregnancy coinciding with placentation. Also up-regulated in joint cartilage affected by arthritis. Belongs to the peptidase S1C family. endopeptidase activity serine-type endopeptidase activity protein binding insulin-like growth factor binding extracellular region proteolysis peptidase activity serine-type peptidase activity hydrolase activity negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway uc008xea.1 uc008xea.2 uc008xea.3 uc008xea.4 
ENSMUST00000087654.5 Zfp763 ENSMUST00000087654.5 zinc finger protein 763 (from RefSeq NM_028543.3) ENSMUST00000087654.1 ENSMUST00000087654.2 ENSMUST00000087654.3 ENSMUST00000087654.4 NM_028543 Q8BIC7 Q8BIC7_MOUSE Zfp763 uc008bxy.1 uc008bxy.2 uc008bxy.3 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc008bxy.1 uc008bxy.2 uc008bxy.3 
ENSMUST00000087659.11 Hecw2 ENSMUST00000087659.11 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2, transcript variant 1 (from RefSeq NM_001001883.3) ENSMUST00000087659.1 ENSMUST00000087659.10 ENSMUST00000087659.2 ENSMUST00000087659.3 ENSMUST00000087659.4 ENSMUST00000087659.5 ENSMUST00000087659.6 ENSMUST00000087659.7 ENSMUST00000087659.8 ENSMUST00000087659.9 HECW2_MOUSE Kiaa1301 NM_001001883 Nedl2 Q3KNL8 Q6I6G8 Q6ZPU4 Q8C956 uc007azk.1 uc007azk.2 uc007azk.3 uc007azk.4 E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Protein modification; protein ubiquitination. Interacts with TP73 (By similarity). Interacts with FZR1 (By similarity). Cytoplasm Cytoplasm, cytoskeleton, spindle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6I6G8-1; Sequence=Displayed; Name=2; IsoId=Q6I6G8-2; Sequence=VSP_023078; protein polyubiquitination ubiquitin-protein transferase activity cytoplasm spindle cytoskeleton ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity regulation of mitotic metaphase/anaphase transition proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process regulation of dendrite morphogenesis ubiquitin protein ligase activity mitotic spindle negative regulation of sodium ion transmembrane transporter activity uc007azk.1 uc007azk.2 uc007azk.3 uc007azk.4 
ENSMUST00000087666.11 Zfp952 ENSMUST00000087666.11 zinc finger protein 952 (from RefSeq NM_001045559.1) B0V2W4 B0V2W4_MOUSE D3Z6L1 ENSMUST00000087666.1 ENSMUST00000087666.10 ENSMUST00000087666.2 ENSMUST00000087666.3 ENSMUST00000087666.4 ENSMUST00000087666.5 ENSMUST00000087666.6 ENSMUST00000087666.7 ENSMUST00000087666.8 ENSMUST00000087666.9 NM_001045559 Zfp952 uc008bxw.1 uc008bxw.2 uc008bxw.3 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc008bxw.1 uc008bxw.2 uc008bxw.3 
ENSMUST00000087674.6 Hmx1 ENSMUST00000087674.6 H6 homeobox 1, transcript variant 1 (from RefSeq NM_010445.4) ENSMUST00000087674.1 ENSMUST00000087674.2 ENSMUST00000087674.3 ENSMUST00000087674.4 ENSMUST00000087674.5 H6 HMX1_MOUSE NM_010445 O70218 uc008xds.1 uc008xds.2 uc008xds.3 DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear. Nucleus Expressed in neural crest-derived tissues, including, nerve ganglia and cranial mesenchyme. On 9.5 dpc expressed in the trigeminal (V) ganglion. On 10.5-11 dpc, expressed in the eye, second branchial arch and the dorsal root ganglion. On 11.5-12 dpc, expressed in the lens and neural epithelium of the eye. On 14-16 dpc, expressed in the sympathetic ganglon and dorso-lateral mesenchyme near the developing ear. Belongs to the HMX homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development sequence-specific DNA binding negative regulation of transcription, DNA-templated uc008xds.1 uc008xds.2 uc008xds.3 
ENSMUST00000087675.9 Dera ENSMUST00000087675.9 deoxyribose-phosphate aldolase (from RefSeq NM_172733.1) DEOC_MOUSE ENSMUST00000087675.1 ENSMUST00000087675.2 ENSMUST00000087675.3 ENSMUST00000087675.4 ENSMUST00000087675.5 ENSMUST00000087675.6 ENSMUST00000087675.7 ENSMUST00000087675.8 NM_172733 Q3UD33 Q91YP3 Q9CZI8 uc009enh.1 uc009enh.2 uc009enh.3 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation. Reaction=2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate; Xref=Rhea:RHEA:12821, ChEBI:CHEBI:15343, ChEBI:CHEBI:59776, ChEBI:CHEBI:62877; EC=4.1.2.4; Evidence=; Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2- deoxy-alpha-D-ribose 1-phosphate: step 2/2. Interacts with YBX1. Cytoplasm Cytoplasmic granule Nucleus Note=Recruited to stress granules but not to processing bodies upon arsenite or clotrimazole treatment or energy deprivation. Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. catalytic activity deoxyribose-phosphate aldolase activity nucleus cytoplasm deoxyribonucleotide catabolic process carbohydrate catabolic process lyase activity deoxyribonucleoside catabolic process deoxyribose phosphate catabolic process uc009enh.1 uc009enh.2 uc009enh.3 
ENSMUST00000087689.5 Prune2 ENSMUST00000087689.5 prune homolog 2 (from RefSeq NM_181348.4) Bmcc1 ENSMUST00000087689.1 ENSMUST00000087689.2 ENSMUST00000087689.3 ENSMUST00000087689.4 Kiaa0367 NM_181348 PRUN2_MOUSE Q501M3 Q52KR3 Q6A079 Q8BW65 Q8BYM6 Q9D217 uc008gxg.1 uc008gxg.2 uc008gxg.3 May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. Cytoplasm Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q52KR3-1; Sequence=Displayed; Name=2; IsoId=Q52KR3-2; Sequence=VSP_022905, VSP_022906, VSP_022908; Name=3; IsoId=Q52KR3-3; Sequence=VSP_022905, VSP_022908; Name=4; IsoId=Q52KR3-4; Sequence=VSP_022905, VSP_039358; Name=5; IsoId=Q52KR3-5; Sequence=VSP_039356, VSP_039357; Name=6; IsoId=Q52KR3-6; Sequence=VSP_039358; In the embryo specifically expressed in neural tube and neural crest-related tissues. At 10.5 dpc, highly expressed in neural tube and pharyngeal arches which are derived from neural crest. Expression is more restricted in the later stages of development. At 12.5 dpc, expressed in spinal cord, hindbrain, midbrain, forebrain and dorsal root ganglia (DRG). Although the expression at 14.5 dpc is similar to those in 12.5 dpc, the regions expressing in hindbrain, spinal cord and forebrain at 14.5 dpc are more dorsally restricted than at 12.5 dpc. Down-regulated after nerve growth factor (NGF)-induced differentiation, and up-regulated during the NGF-depletion-induced apoptosis. Belongs to the PPase class C family. Prune subfamily. Sequence=AAH94224.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32217.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE41506.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; exopolyphosphatase activity cytoplasm polyphosphate catabolic process apoptotic process pyrophosphatase activity uc008gxg.1 uc008gxg.2 uc008gxg.3 
ENSMUST00000087694.5 Gm10351 ENSMUST00000087694.5 Gm10351 (from geneSymbol) AB010332 ENSMUST00000087694.1 ENSMUST00000087694.2 ENSMUST00000087694.3 ENSMUST00000087694.4 uc291oym.1 uc291oym.2 uc291oym.1 uc291oym.2 
ENSMUST00000087714.6 H4c11 ENSMUST00000087714.6 H4 clustered histone 11 (from RefSeq NM_178210.2) A0AUM5 A4FUP8 A4QMY0 ENSMUST00000087714.1 ENSMUST00000087714.2 ENSMUST00000087714.3 ENSMUST00000087714.4 ENSMUST00000087714.5 H4-12 H4-53 H4_MOUSE H4c1 H4c12 H4c14 H4c16 H4c2 H4c3 H4c4 H4c6 H4c8 H4c9 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist1h4m Hist2h4 Hist2h4a Hist4h4 NM_178210 P02304 P02305 P62806 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 uc007pre.1 uc007pre.2 uc007pre.3 uc007pre.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3- H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). P62806; Q8CDM1: Atad2; NbExp=2; IntAct=EBI-299632, EBI-2944582; P62806; Q9EQQ9: Oga; NbExp=2; IntAct=EBI-299632, EBI-8321615; Nucleus Chromosome Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Sumoylated, which is associated with transcriptional repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H4 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly DNA-templated transcription, initiation protein domain specific binding macromolecular complex negative regulation of megakaryocyte differentiation protein heterodimerization activity protein heterotetramerization uc007pre.1 uc007pre.2 uc007pre.3 uc007pre.4 
ENSMUST00000087721.10 Ephx3 ENSMUST00000087721.10 epoxide hydrolase 3, transcript variant 3 (from RefSeq NR_175782.1) A0A0R4J127 A0A0R4J127_MOUSE ENSMUST00000087721.1 ENSMUST00000087721.2 ENSMUST00000087721.3 ENSMUST00000087721.4 ENSMUST00000087721.5 ENSMUST00000087721.6 ENSMUST00000087721.7 ENSMUST00000087721.8 ENSMUST00000087721.9 Ephx3 NR_175782 uc008bvy.1 uc008bvy.2 Belongs to the AB hydrolase superfamily. Epoxide hydrolase family. catalytic activity epoxide hydrolase activity membrane integral component of membrane intracellular membrane-bounded organelle epoxide metabolic process uc008bvy.1 uc008bvy.2 
ENSMUST00000087723.5 Notch3 ENSMUST00000087723.5 notch 3 (from RefSeq NM_008716.3) ENSMUST00000087723.1 ENSMUST00000087723.2 ENSMUST00000087723.3 ENSMUST00000087723.4 NM_008716 NOTC3_MOUSE Q61982 uc008bvx.1 uc008bvx.2 uc008bvx.3 uc008bvx.4 Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development. Interacts with PSMA1 (By similarity). Heterodimer of a C- terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with HIF1AN. PRO_0000007697; Q77CA8: LRORF2; Xeno; NbExp=3; IntAct=EBI-11292908, EBI-11292862; Cell membrane ; Single-pass type I membrane protein. [Notch 3 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus. Proliferating neuroepithelium. CNS development. The EGF-like domains 10 and 11 are required for binding the ligands JAG1 and DLL1. Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans- Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane- associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma- secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane. Phosphorylated. Hydroxylated by HIF1AN. Belongs to the NOTCH family. negative regulation of transcription from RNA polymerase II promoter calcium ion binding protein binding nucleus nucleoplasm cytosol plasma membrane integral component of plasma membrane regulation of transcription, DNA-templated Notch signaling pathway multicellular organism development cell surface actin cytoskeleton membrane integral component of membrane enzyme binding cell differentiation forebrain development signaling receptor activity identical protein binding receptor complex negative regulation of cell differentiation negative regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle cell proliferation neuron fate commitment artery morphogenesis regulation of developmental process glomerular capillary formation uc008bvx.1 uc008bvx.2 uc008bvx.3 uc008bvx.4 
ENSMUST00000087737.10 Tnip2 ENSMUST00000087737.10 TNFAIP3 interacting protein 2 (from RefSeq NM_139064.2) Abin2 ENSMUST00000087737.1 ENSMUST00000087737.2 ENSMUST00000087737.3 ENSMUST00000087737.4 ENSMUST00000087737.5 ENSMUST00000087737.6 ENSMUST00000087737.7 ENSMUST00000087737.8 ENSMUST00000087737.9 NM_139064 Q3TVF3 Q99JG7 TNIP2_MOUSE Tnip2 uc008xcj.1 uc008xcj.2 uc008xcj.3 Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF- kappa-B p50-p65 and p50-c-Rel complexes. Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts with polyubiquitin (By similarity). Cytoplasm Ubiquitously expressed in all tissues examined. In vitro phosphorylated by CHUK. Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination. Deubiquitinated by USP35; leading to stabilization and inhibition of TNFalpha-induced NF-kappa-B activation. protein binding nucleus nucleoplasm cytoplasm cytosol apoptotic process inflammatory response I-kappaB kinase/NF-kappaB signaling protein kinase binding CD40 signaling pathway polyubiquitin binding toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway toll-like receptor 9 signaling pathway positive regulation of macrophage activation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription from RNA polymerase II promoter metal ion binding protein stabilization positive regulation of B cell activation interleukin-1-mediated signaling pathway K63-linked polyubiquitin binding cellular response to lipopolysaccharide negative regulation of endothelial cell apoptotic process uc008xcj.1 uc008xcj.2 uc008xcj.3 
ENSMUST00000087773.2 Or5b101 ENSMUST00000087773.2 olfactory receptor family 5 subfamily B member 101 (from RefSeq NM_146700.1) ENSMUST00000087773.1 NM_146700 Olfr1453 Or5b101 Q8VFX0 Q8VFX0_MOUSE uc008gvb.1 uc008gvb.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gvb.1 uc008gvb.2 
ENSMUST00000087812.2 Or5an10 ENSMUST00000087812.2 olfactory receptor family 5 subfamily AN member 10 (from RefSeq NM_146687.2) A0PK57 A0PK57_MOUSE ENSMUST00000087812.1 NM_146687 Olfr1436 Or5an10 uc008gtw.1 uc008gtw.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC127991.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gtw.1 uc008gtw.2 
ENSMUST00000087818.2 Or5an1c ENSMUST00000087818.2 olfactory receptor family 5 subfamily AN member 1C (from RefSeq NM_146688.2) ENSMUST00000087818.1 NM_146688 Olfr262 Or5an1c Q8VFV8 Q8VFV8_MOUSE uc008gtt.1 uc008gtt.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gtt.1 uc008gtt.2 
ENSMUST00000087853.4 Prb1a ENSMUST00000087853.4 proline-rich protein BstNI subfamily 1A (from RefSeq NM_198669.1) ENSMUST00000087853.1 ENSMUST00000087853.2 ENSMUST00000087853.3 NM_198669 Prb1 Prb1a Q91X93 Q91X93_MOUSE uc009ejc.1 uc009ejc.2 molecular_function cellular_component biological_process uc009ejc.1 uc009ejc.2 
ENSMUST00000087864.12 Uvssa ENSMUST00000087864.12 UV stimulated scaffold protein A, transcript variant 4 (from RefSeq NR_153108.1) B2RQ84 B7ZN03 ENSMUST00000087864.1 ENSMUST00000087864.10 ENSMUST00000087864.11 ENSMUST00000087864.2 ENSMUST00000087864.3 ENSMUST00000087864.4 ENSMUST00000087864.5 ENSMUST00000087864.6 ENSMUST00000087864.7 ENSMUST00000087864.8 ENSMUST00000087864.9 Kiaa1530 NR_153108 Q3U1A8 Q6P7V8 Q6ZPN7 Q9D479 UVSSA_MOUSE uc008xas.1 uc008xas.2 uc008xas.3 Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II- blocking lesions from the transcribed strand of active genes. Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Also facilitates transfer of TFIIH to RNA polymerase II. Not involved in processing oxidative damage. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) during transcription stress. Interacts with the TFIIH complex during transcription stress. Interacts with ERCC6. Interacts with ERCC8. Interacts with USP7. Chromosome Note=Accumulates at UV DNA damage sites. Monoubiquitinated at Lys-416 in response to transcription stress; this promotes efficient transfer of TFIIH to stalled RNA polymerase II. Belongs to the UVSSA family. Sequence=BAB30399.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC98194.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA polymerase II core binding chromosome DNA repair transcription-coupled nucleotide-excision repair cellular response to DNA damage stimulus response to UV protein ubiquitination uc008xas.1 uc008xas.2 uc008xas.3 
ENSMUST00000087867.6 Uprt ENSMUST00000087867.6 uracil phosphoribosyltransferase (from RefSeq NM_001081189.3) B1AVZ0 ENSMUST00000087867.1 ENSMUST00000087867.2 ENSMUST00000087867.3 ENSMUST00000087867.4 ENSMUST00000087867.5 NM_001081189 UPP_MOUSE uc009uai.1 uc009uai.2 uc009uai.3 Cytoplasm Nucleus Belongs to the UPRTase family. The uracil binding region known from UPRTases is missing. nucleotide binding GTP binding nucleus cytoplasm cytosol UMP biosynthetic process female pregnancy lactation nucleoside metabolic process kinase activity phosphorylation response to insulin uc009uai.1 uc009uai.2 uc009uai.3 
ENSMUST00000087879.11 Nexmif ENSMUST00000087879.11 neurite extension and migration factor (from RefSeq NM_001077354.3) ENSMUST00000087879.1 ENSMUST00000087879.10 ENSMUST00000087879.2 ENSMUST00000087879.3 ENSMUST00000087879.4 ENSMUST00000087879.5 ENSMUST00000087879.6 ENSMUST00000087879.7 ENSMUST00000087879.8 ENSMUST00000087879.9 Kiaa2022 NEXMI_MOUSE NM_001077354 Nexmif Q003Y8 Q5DTT1 Q8BW26 Q8BYR0 uc009uab.1 uc009uab.2 uc009uab.3 uc009uab.4 uc009uab.5 Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1). Nucleus toplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5DTT1-1; Sequence=Displayed; Name=2; IsoId=Q5DTT1-2; Sequence=VSP_021372; Expressed in the brain, particularly during the late embryonic and perinatal stages of development (PubMed:22531377). In the developing brain, it is expressed only in the cortical plate and subplate region but not in the intermediate or ventricular zone (PubMed:27822498). Widely expressed in brain by postmitotic neurons from early development through early adulthood. Sequence=BAD90269.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of cell-matrix adhesion nucleus cytoplasm multicellular organism development nervous system development negative regulation of cell adhesion mediated by integrin negative regulation of cell-cell adhesion mediated by cadherin negative regulation of neuron migration uc009uab.1 uc009uab.2 uc009uab.3 uc009uab.4 uc009uab.5 
ENSMUST00000087883.13 Col3a1 ENSMUST00000087883.13 collagen, type III, alpha 1 (from RefSeq NM_009930.2) Col3a1 ENSMUST00000087883.1 ENSMUST00000087883.10 ENSMUST00000087883.11 ENSMUST00000087883.12 ENSMUST00000087883.2 ENSMUST00000087883.3 ENSMUST00000087883.4 ENSMUST00000087883.5 ENSMUST00000087883.6 ENSMUST00000087883.7 ENSMUST00000087883.8 ENSMUST00000087883.9 NM_009930 Q3TVI5 Q3TVI5_MOUSE uc007awq.1 uc007awq.2 uc007awq.3 This gene encodes the alpha-1 subunit of the fibril-forming type III collagen found in bone, cartilage, dentin, tendon, bone marrow stroma and other connective tissue. The encoded protein forms homotrimeric type III procollagen that undergoes proteolytic processing during fibril formation. A majority of mice lacking the encoded protein die within two days of birth but about 5% of the animals survive to adulthood. The surviving mice exhibit severe cortical malformation and experience significantly shorter lifespan. The mutant mouse named 'tight skin 2' exhibiting systemic sclerosis phenotype was found to harbor a missense point mutation in this gene. A pseudogene of this gene has been defined on chromosome 8. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK220558.1, AK159920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## skeletal system development protease binding integrin binding extracellular matrix structural constituent collagen trimer collagen type III trimer extracellular space cell-matrix adhesion transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway heart development response to radiation response to mechanical stimulus peptide cross-linking collagen fibril organization response to cytokine wound healing skin development platelet-derived growth factor binding negative regulation of immune response supramolecular fiber organization uc007awq.1 uc007awq.2 uc007awq.3 
ENSMUST00000087908.10 Stx16 ENSMUST00000087908.10 syntaxin 16, transcript variant 8 (from RefSeq NR_156433.1) A2ACM7 ENSMUST00000087908.1 ENSMUST00000087908.2 ENSMUST00000087908.3 ENSMUST00000087908.4 ENSMUST00000087908.5 ENSMUST00000087908.6 ENSMUST00000087908.7 ENSMUST00000087908.8 ENSMUST00000087908.9 NR_156433 Q8BVI5 STX16_MOUSE uc008oel.1 uc008oel.2 uc008oel.3 SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Interacts with GCC2 (By similarity). Interacts with BAIAP3; this interaction is increased in the presence of calcium (By similarity). Q8BVI5; O08700: Vps45; Xeno; NbExp=6; IntAct=EBI-3871057, EBI-7849203; Golgi apparatus membrane ; Single- pass type IV membrane protein Belongs to the syntaxin family. Sequence=BAC37129.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane SNARE binding SNAP receptor activity protein binding cytoplasm Golgi apparatus trans-Golgi network cytosol intracellular protein transport vesicle fusion endomembrane system protein transport membrane integral component of membrane vesicle-mediated transport syntaxin binding integral component of synaptic vesicle membrane SNARE complex Golgi cisterna retrograde transport, endosome to Golgi intracellular membrane-bounded organelle vesicle docking perinuclear region of cytoplasm Golgi ribbon formation endoplasmic reticulum uc008oel.1 uc008oel.2 uc008oel.3 
ENSMUST00000087916.11 Hdac8 ENSMUST00000087916.11 histone deacetylase 8, transcript variant 1 (from RefSeq NM_027382.4) ENSMUST00000087916.1 ENSMUST00000087916.10 ENSMUST00000087916.2 ENSMUST00000087916.3 ENSMUST00000087916.4 ENSMUST00000087916.5 ENSMUST00000087916.6 ENSMUST00000087916.7 ENSMUST00000087916.8 ENSMUST00000087916.9 HDAC8_MOUSE NM_027382 Q3V270 Q8VH37 Q9D0K6 uc009typ.1 uc009typ.2 uc009typ.3 uc009typ.4 Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones. Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA- COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58197; Evidence=; Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl- [protein]; Xref=Rhea:RHEA:58108, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58109; Evidence=; Reaction=H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]; Xref=Rhea:RHEA:69172, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13707, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:35899, ChEBI:CHEBI:137954; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69173; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 1 divalent metal cation per subunit. ; Its activity is inhibited by trichostatin A (TSA) and butyrate, 2 well known histone deacetylase inhibitors. histone deacetylase inhibitor. Interacts with CBFA2T3 (PubMed:11533236). Interacts with phosphorylated SMG5/EST1B; this interaction protects SMG5 from ubiquitin-mediated degradation (By similarity). Associates with alpha- SMA (smooth muscle alpha-actin) (By similarity). Nucleus Chromosome Cytoplasm Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VH37-1; Sequence=Displayed; Name=2; IsoId=Q8VH37-2; Sequence=VSP_007178, VSP_007179; Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4. Belongs to the histone deacetylase family. HD type 1 subfamily. histone deacetylase complex chromatin binding histone deacetylase activity nucleus cytoplasm plasma membrane chromatin organization sister chromatid cohesion transcription factor binding negative regulation of gene expression histone deacetylation hydrolase activity deacetylase activity Hsp70 protein binding negative regulation of protein ubiquitination regulation of protein stability NAD-dependent histone deacetylase activity (H3-K14 specific) regulation of telomere maintenance cellular response to trichostatin A negative regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding Hsp90 protein binding histone H3 deacetylation histone H4 deacetylation regulation of cohesin loading cellular response to forskolin negative regulation of histone H3-K9 acetylation uc009typ.1 uc009typ.2 uc009typ.3 uc009typ.4 
ENSMUST00000087923.4 Ms4a15 ENSMUST00000087923.4 membrane-spanning 4-domains, subfamily A, member 15, transcript variant 2 (from RefSeq NM_001404619.1) B2RVI3 ENSMUST00000087923.1 ENSMUST00000087923.2 ENSMUST00000087923.3 M4A15_MOUSE NM_001404619 Q3UPL6 uc008grl.1 uc008grl.2 May be involved in signal transduction as a component of a multimeric receptor complex. Membrane ; Multi-pass membrane protein Belongs to the MS4A family. molecular_function cellular_component biological_process membrane integral component of membrane uc008grl.1 uc008grl.2 
ENSMUST00000087942.6 Rab44 ENSMUST00000087942.6 Rab44 (from geneSymbol) A0A2Y9CZI3 A0A2Y9CZI3_MOUSE AK036563 ENSMUST00000087942.1 ENSMUST00000087942.2 ENSMUST00000087942.3 ENSMUST00000087942.4 ENSMUST00000087942.5 Rab44 uc008bsi.1 uc008bsi.2 GTPase activity GTP binding uc008bsi.1 uc008bsi.2 
ENSMUST00000087948.11 Med12 ENSMUST00000087948.11 mediator complex subunit 12 (from RefSeq NM_021521.2) A2AGH6 A2AGH7 ENSMUST00000087948.1 ENSMUST00000087948.10 ENSMUST00000087948.2 ENSMUST00000087948.3 ENSMUST00000087948.4 ENSMUST00000087948.5 ENSMUST00000087948.6 ENSMUST00000087948.7 ENSMUST00000087948.8 ENSMUST00000087948.9 Kiaa0192 MED12_MOUSE Mopa NM_021521 O88542 Q571H3 Q6PGB4 Q6PGD8 Tnrc11 Trap230 uc009txe.1 uc009txe.2 uc009txe.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Also interacts with CTNNB1 and GLI3 (By similarity). A2AGH6; Q8R3L8: Cdk8; NbExp=3; IntAct=EBI-5744969, EBI-5745402; A2AGH6; P37173: TGFBR2; Xeno; NbExp=3; IntAct=EBI-5744969, EBI-296151; Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AGH6-1; Sequence=Displayed; Name=2; IsoId=A2AGH6-2; Sequence=VSP_029978, VSP_029979, VSP_029980; Name=3; IsoId=A2AGH6-3; Sequence=VSP_029977, VSP_029978; Belongs to the Mediator complex subunit 12 family. Sequence=AAC83164.1; Type=Erroneous initiation; Evidence=; ubiquitin ligase complex RNA polymerase II distal enhancer sequence-specific DNA binding somitogenesis neural tube closure chromatin binding transcription cofactor activity transcription coactivator activity protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter endoderm development heart development beta-catenin binding protein C-terminus binding transcription factor binding oligodendrocyte development Schwann cell development protein ubiquitination mediator complex stem cell population maintenance protein domain specific binding spinal cord development neural tube development post-anal tail morphogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter thyroid hormone receptor binding embryonic organ development embryonic neurocranium morphogenesis canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway ubiquitin protein ligase activity axis elongation involved in somitogenesis embryonic brain development uc009txe.1 uc009txe.2 uc009txe.3 
ENSMUST00000087950.4 Cbln4 ENSMUST00000087950.4 cerebellin 4 precursor protein (from RefSeq NM_175631.3) CBLN4_MOUSE Cblnl1 ENSMUST00000087950.1 ENSMUST00000087950.2 ENSMUST00000087950.3 NM_175631 Q505H5 Q8BME9 Q8BMF0 uc008ock.1 uc008ock.2 uc008ock.3 Acts as a synaptic organizer in specific subsets of neurons in the brain (PubMed:29691328). Essential for the formation and maintenance of inhibitory GABAergic synapses (PubMed:25534236). Promotes the development of dendrite-targeting inhibitory GABAergic synapses made by somatostatin-positive interneurons (PubMed:30679375). May contribute to the function of ventral medial habenula region of the brain implicated in the regulation of anxiety-related behaviors (PubMed:30287486). May play a role in CBLN3 export from the endoplasmic reticulum and secretion (PubMed:17030622). Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the globular C1q domains. The trimers associate via N- terminal cysteine residues to form disulfide-linked hexamers (By similarity). May form oligomers with CBLN1, CBLN2 and CBLN3 prior to secretion (PubMed:17030622, PubMed:29782851). Once secreted, does not interact with other CBLN family members (PubMed:17030622). Strongly interacts with DCC in a NTN1-displaceable fashion (PubMed:22220752, PubMed:29782851). Weakly binds to NRXN1 and NRXN2 long and short isoforms produced by alternative promoter usage (PubMed:22220752, PubMed:29782851). Interaction with NRXN3 short isoform is hardly detectable; no interaction at all with NRXN3 long isoform (PubMed:22220752, PubMed:29782851). Does not interact with NEO1, GRID1 and GRID2 (PubMed:22220752, PubMed:29782851). Secreted napse Note=Detected at GABAergic synapses. Expressed in brain with high levels in particular thalamic nuclei. In the thalamus, predominantly expressed in neurons within the parafascicular nucleus. Found in the hippocampus, mostly in the dendrites and somata of pyramidal neurons (at protein level). Very low or no expression in most other brain regions. Highly expressed in the ventral medial habenula. In the developing brain, expressed as early as 10- 13 dpc. Expression level peaks at 18 dpc and gradually decreases afterwards. Expressed in developing somatostatin-positive basket cells. Sialoglycoprotein. Mutant animals are fertile, have normal life spans and have no overt anatomical abnormalities (PubMed:22220752). They have a normal corpus callosum, hippocampal commisure and pontine nucleus and no other gross neuroanatomical abnormalities (PubMed:22220752). Mice exhibit increased anxiety-related behavior (PubMed:30287486). Triple CBLN1, CBLN2 and CBLN4 knockout mice exhibit impairments in sensory processing and sensorimotor gating, in addition to severe motor deficits, seizures and reduced synapse density in the hippocampus of aging mice (PubMed:29691328). protein binding extracellular region extracellular space protein secretion cell junction synapse uc008ock.1 uc008ock.2 uc008ock.3 
ENSMUST00000087978.5 S1pr3 ENSMUST00000087978.5 sphingosine-1-phosphate receptor 3 (from RefSeq NM_010101.4) ENSMUST00000087978.1 ENSMUST00000087978.2 ENSMUST00000087978.3 ENSMUST00000087978.4 Edg3 Lpb3 NM_010101 Q8BP20 Q9Z0U9 S1PR3_MOUSE uc007qmf.1 uc007qmf.2 uc007qmf.3 uc007qmf.4 This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. The gene product mediates HDL and HDL-associated lysophospholipid-induced vasorelaxation, and it coordinates with other lysophospholipid receptors in the process of angiogenesis. [provided by RefSeq, Jan 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK084944.1, AK029852.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Cell membrane; Multi-pass membrane protein. Most abundant in heart, lung, kidney and spleen; low but detectable in brain, thymus, muscle and testis; and nearly undetectable in liver, stomach, and intestine. Expressed in embryonic lung from embryonic day 14-18. Also abundantly detected in embryonic nasal cartilage, sphenoid bone, vena cava, Meckel's cartilage/incisor teeth, genital tubercle and bladder. Belongs to the G-protein coupled receptor 1 family. cytokine production sphingosine-1-phosphate signaling pathway G-protein coupled receptor activity integrin binding plasma membrane integral component of plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Notch signaling pathway membrane integral component of membrane regulation of interleukin-1 beta production sphingosine-1-phosphate receptor activity negative regulation of establishment of endothelial barrier uc007qmf.1 uc007qmf.2 uc007qmf.3 uc007qmf.4 
ENSMUST00000087984.11 Dlg3 ENSMUST00000087984.11 discs large MAGUK scaffold protein 3, transcript variant 1 (from RefSeq NM_016747.5) DLG3_MOUSE Dlgh3 ENSMUST00000087984.1 ENSMUST00000087984.10 ENSMUST00000087984.2 ENSMUST00000087984.3 ENSMUST00000087984.4 ENSMUST00000087984.5 ENSMUST00000087984.6 ENSMUST00000087984.7 ENSMUST00000087984.8 ENSMUST00000087984.9 NM_016747 P70175 uc009twm.1 uc009twm.2 uc009twm.3 uc009twm.4 uc009twm.5 Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Interacts through its PDZ domains with NETO1, GRIN2B, SYNGAP1 and APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 (By similarity). Interacts with FRMPD4 (via C-terminus) (By similarity). Interacts with LRFN1, LRFN2 and LRFN4 (By similarity). Interacts with FLTP. Interacts with GPR85 (PubMed:25780553). Interacts with DGKI (via PDZ-binding motif) (PubMed:21119615). P70175; P35347: Crhr1; NbExp=3; IntAct=EBI-396969, EBI-16879653; P70175; Q62108: Dlg4; NbExp=4; IntAct=EBI-396969, EBI-300895; Belongs to the MAGUK family. establishment of planar polarity protein binding cytoplasm plasma membrane cell-cell junction bicellular tight junction protein C-terminus binding negative regulation of phosphatase activity postsynaptic density basolateral plasma membrane kinase binding phosphatase binding protein phosphatase binding protein domain specific binding cell junction PDZ domain binding growth cone ubiquitin protein ligase binding AMPA glutamate receptor complex ionotropic glutamate receptor binding neuronal cell body receptor clustering dendritic shaft establishment or maintenance of epithelial cell apical/basal polarity synapse positive regulation of protein tyrosine kinase activity receptor localization to synapse cell-cell adhesion structural constituent of postsynaptic density glutamatergic synapse regulation of postsynaptic specialization membrane neurotransmitter receptor levels postsynaptic density, intracellular component maintenance of postsynaptic density structure ionotropic glutamate receptor complex uc009twm.1 uc009twm.2 uc009twm.3 uc009twm.4 uc009twm.5 
ENSMUST00000087996.7 Krt77 ENSMUST00000087996.7 keratin 77 (from RefSeq NM_001003667.2) ENSMUST00000087996.1 ENSMUST00000087996.2 ENSMUST00000087996.3 ENSMUST00000087996.4 ENSMUST00000087996.5 ENSMUST00000087996.6 K2C1B_MOUSE Krt1b NM_001003667 Q6IFZ6 uc007xud.1 uc007xud.2 uc007xud.3 Expressed in stratified epithelia. Undergoes deimination of some arginine residues (citrullination). There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. cytoskeleton intermediate filament keratin filament uc007xud.1 uc007xud.2 uc007xud.3 
ENSMUST00000088001.6 Adnp ENSMUST00000088001.6 activity-dependent neuroprotective protein, transcript variant 2 (from RefSeq NM_009628.3) A2BDX0 ADNP_MOUSE ENSMUST00000088001.1 ENSMUST00000088001.2 ENSMUST00000088001.3 ENSMUST00000088001.4 ENSMUST00000088001.5 NM_009628 Q9Z103 uc008oaq.1 uc008oaq.2 uc008oaq.3 uc008oaq.4 This gene encodes a member of a protein family characterized by nine zinc finger motifs followed by a homeobox domain. In vitro studies demonstrate that the encoded protein interacts with the brahma-related gene1-associated or hBRM factors (BAF) gene expression regulating complex, components of the protein translation machinery, and microtubule-associated proteins. This gene has been implicated in neuroprotection through various processes that include chromatin remodeling, splicing, cytoskeletal reorganization, and autophagy. Homozygous mutant knockout mice display embryonic lethality with defects in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]. May be involved in transcriptional regulation (PubMed:23071114, PubMed:32533114). May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1 (PubMed:32533114). May be required for neural induction and neuronal differentiation (PubMed:32533114). May be involved in erythroid differentiation (PubMed:23071114). Interacts (via N-terminal region) with beta-catenin/CTNNB1 (via the central armadillo domains); interaction is direct and stabilizes CTNNB1 by modulating its phosphorylation by glycogen synthase kinase-3 beta GSK3B. Nucleus Chromosome Expressed in the brain, with a higher expression in cerebellum and hippocampus. Weakly expressed in lung, kidney and intestine, and expressed at intermediate level in testis. By the neuroprotective peptide VIP. When isolated from the sequence, the neuroprotective peptide provides neuroprotection at subfemtomolar concentrations against toxicity associated with tetrodoxin (electrical blockade), the amyloid-beta peptide (the Alzheimer disease neurotoxin), N-methyl- aspartate (excitotoxicity), and the human immunideficiency virus (HIV) envelope protein. nucleic acid binding DNA binding chromatin binding copper ion binding protein binding extracellular space nucleus cytoplasm short-term memory response to carbohydrate response to inorganic substance negative regulation of gene expression regulation of protein ADP-ribosylation positive regulation of neuron projection development cGMP-mediated signaling axon dendrite cellular response to extracellular stimulus negative regulation of protein binding activation of protein kinase activity nitric oxide homeostasis peptide binding neuronal cell body negative regulation of neuron apoptotic process estrous cycle positive regulation of axon extension metal ion binding beta-tubulin binding positive regulation of peptidyl-tyrosine phosphorylation negative regulation of synaptic transmission positive regulation of synapse assembly uc008oaq.1 uc008oaq.2 uc008oaq.3 uc008oaq.4 
ENSMUST00000088010.12 Gtf3c2 ENSMUST00000088010.12 general transcription factor IIIC, polypeptide 2, beta (from RefSeq NM_027901.2) ENSMUST00000088010.1 ENSMUST00000088010.10 ENSMUST00000088010.11 ENSMUST00000088010.2 ENSMUST00000088010.3 ENSMUST00000088010.4 ENSMUST00000088010.5 ENSMUST00000088010.6 ENSMUST00000088010.7 ENSMUST00000088010.8 ENSMUST00000088010.9 Kiaa0011 NM_027901 Q3U7Z9 Q80XQ7 Q8BJJ4 Q8BL74 Q8BLP3 Q8K1J1 Q9CSS0 Q9CVE6 Q9DBK6 TF3C2_MOUSE uc008wxh.1 uc008wxh.2 uc008wxh.3 Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 (By similarity). Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Nucleus Sequence=BAC31709.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAC97843.1; Type=Erroneous initiation; Evidence=; transcription factor TFIIIC complex nucleus transcription from RNA polymerase III promoter transcription factor activity, core RNA polymerase III binding DNA binding uc008wxh.1 uc008wxh.2 uc008wxh.3 
ENSMUST00000088018.5 Krt74 ENSMUST00000088018.5 keratin 74 (from RefSeq NR_033444.1) ENSMUST00000088018.1 ENSMUST00000088018.2 ENSMUST00000088018.3 ENSMUST00000088018.4 NR_033444 uc011zzt.1 uc011zzt.2 uc011zzt.3 uc011zzt.4 uc011zzt.1 uc011zzt.2 uc011zzt.3 uc011zzt.4 
ENSMUST00000088029.8 Nms ENSMUST00000088029.8 neuromedin S, transcript variant 1 (from RefSeq NM_001011684.2) B2RSM4 ENSMUST00000088029.1 ENSMUST00000088029.2 ENSMUST00000088029.3 ENSMUST00000088029.4 ENSMUST00000088029.5 ENSMUST00000088029.6 ENSMUST00000088029.7 NMS_MOUSE NM_001011684 Q5H8A1 uc007atb.1 uc007atb.2 This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in the regulation of circadian rhythm, anorexigenic action, antidiuretic action, cardiovascular function and stimulation of oxytocin and vasopressin release. Mice lacking the encoded neuropeptide exhibit decreased heart rate without any accompanying changes in blood pressure. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature peptide. [provided by RefSeq, Aug 2015]. Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. Secreted Belongs to the NmU family. G-protein coupled receptor binding extracellular region neuropeptide signaling pathway locomotor rhythm uc007atb.1 uc007atb.2 
ENSMUST00000088046.2 Klri1 ENSMUST00000088046.2 killer cell lectin-like receptor family I member 1 (from RefSeq NM_001012520.3) B2KG20 ENSMUST00000088046.1 KLRI1_MOUSE Klri1 NM_001012520 Q5DT35 uc009egq.1 uc009egq.2 Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates inhibition of NK cell cytolytic activity. Heterodimer with KLRE1. Interacts with PTPN6. Cell membrane ; Single-pass type II membrane protein Expressed in natural killer (NK) cells. Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases leading to down-regulation of cell activation. plasma membrane integral component of plasma membrane membrane integral component of membrane carbohydrate binding uc009egq.1 uc009egq.2 
ENSMUST00000088049.5 Krt86 ENSMUST00000088049.5 keratin 86 (from RefSeq NM_010667.2) ENSMUST00000088049.1 ENSMUST00000088049.2 ENSMUST00000088049.3 ENSMUST00000088049.4 KRT86_MOUSE Krt2-10 Krthb6 NM_010667 P97861 Q3TTV9 uc007xti.1 uc007xti.2 uc007xti.3 Heterotetramer of two type I and two type II keratins. There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). Belongs to the intermediate filament family. intermediate filament keratin filament uc007xti.1 uc007xti.2 uc007xti.3 
ENSMUST00000088075.8 Clec9a ENSMUST00000088075.8 C-type lectin domain family 9, member a, transcript variant 2 (from RefSeq NM_172732.3) B0ZBM3 B0ZBM5 B0ZBM6 B0ZBM7 CLC9A_MOUSE Dngr-1 ENSMUST00000088075.1 ENSMUST00000088075.2 ENSMUST00000088075.3 ENSMUST00000088075.4 ENSMUST00000088075.5 ENSMUST00000088075.6 ENSMUST00000088075.7 NM_172732 Q5M8M6 Q8BRU4 Q8CBB4 uc009efr.1 uc009efr.2 uc009efr.3 uc009efr.4 Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. Isoform 1: Monomer. Isoform 4: Homodimer. Membrane ; Single- pass type II membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8BRU4-1; Sequence=Displayed; Name=2; Synonyms=Gamma; IsoId=Q8BRU4-2; Sequence=VSP_041500, VSP_041501; Name=3; Synonyms=Delta; IsoId=Q8BRU4-3; Sequence=VSP_041504, VSP_041505; Name=4; Synonyms=Beta; IsoId=Q8BRU4-4; Sequence=VSP_041501; Name=5; Synonyms=Epsilon; IsoId=Q8BRU4-5; Sequence=VSP_041502, VSP_041503; Isoform 4 expressed at high levels by CD8(+) dendritic cells (DCs), and at low levels by plasmacytoid DCs but not by other hematopoietic cells. [Isoform 1]: Not glycosylated. [Isoform 4]: N-glycosylated. Deficient mice shown no alteration of dendritic cell phenotype and numbers and the response of dendritic cells to innate stimuli is not altered. No alterations are found in leukocyte numbers or frequencies in spleen, lymph node or thymus, and mice appear normal and do not develop any obvious symptoms of autoimmune disease. Sequence=BAC29411.1; Type=Frameshift; Evidence=; Name=Functional Glycomics Gateway - Glycan Binding; Note=mCLEC9; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_817"; receptor-mediated endocytosis cell surface membrane integral component of membrane carbohydrate binding positive regulation of cytokine secretion uc009efr.1 uc009efr.2 uc009efr.3 uc009efr.4 
ENSMUST00000088095.7 Ncoa3 ENSMUST00000088095.7 nuclear receptor coactivator 3, transcript variant 1 (from RefSeq NM_008679.4) ENSMUST00000088095.1 ENSMUST00000088095.2 ENSMUST00000088095.3 ENSMUST00000088095.4 ENSMUST00000088095.5 ENSMUST00000088095.6 NM_008679 Ncoa3 Q05BA5 Q05BA5_MOUSE uc008nyi.1 uc008nyi.2 uc008nyi.3 uc008nyi.4 Nucleus Belongs to the SRC/p160 nuclear receptor coactivator family. nuclear chromatin transcription coactivator activity histone acetyltransferase activity nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated positive regulation of gene expression histone acetylation ligand-dependent nuclear receptor binding ligand-dependent nuclear receptor transcription coactivator activity macromolecular complex nuclear hormone receptor binding positive regulation of keratinocyte differentiation positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity protein N-terminus binding cellular response to estradiol stimulus disordered domain specific binding regulation of RNA biosynthetic process uc008nyi.1 uc008nyi.2 uc008nyi.3 uc008nyi.4 
ENSMUST00000088102.12 Zfx ENSMUST00000088102.12 zinc finger protein X-linked, transcript variant 19 (from RefSeq NM_001426102.1) ENSMUST00000088102.1 ENSMUST00000088102.10 ENSMUST00000088102.11 ENSMUST00000088102.2 ENSMUST00000088102.3 ENSMUST00000088102.4 ENSMUST00000088102.5 ENSMUST00000088102.6 ENSMUST00000088102.7 ENSMUST00000088102.8 ENSMUST00000088102.9 NM_001426102 P17011 P17012 ZFX_MOUSE uc009tsz.1 uc009tsz.2 Probable transcriptional activator. Nucleus. Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily. Sequence=AAA40585.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due to a duplication of 120 bp after position 480.; Evidence=; ovarian follicle development nucleic acid binding DNA binding nucleus nucleoplasm nucleolus regulation of transcription, DNA-templated germ cell development spermatogenesis fertilization post-embryonic development multicellular organism growth metal ion binding oocyte development homeostasis of number of cells parental behavior uc009tsz.1 uc009tsz.2 
ENSMUST00000088117.11 Adgrf3 ENSMUST00000088117.11 adhesion G protein-coupled receptor F3 (from RefSeq NM_001014394.2) ADGRF3 AGRF3_MOUSE ENSMUST00000088117.1 ENSMUST00000088117.10 ENSMUST00000088117.2 ENSMUST00000088117.3 ENSMUST00000088117.4 ENSMUST00000088117.5 ENSMUST00000088117.6 ENSMUST00000088117.7 ENSMUST00000088117.8 ENSMUST00000088117.9 F8VPU1 Gm1041 Gpr113 NM_001014394 Pcr113 Pgr23 Q58Y75 Q80T50 uc008wvg.1 uc008wvg.2 Orphan receptor. Membrane ; Multi-pass membrane protein Expression is restricted to testis and circumvallate papillae. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. transmembrane signaling receptor activity G-protein coupled receptor activity signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway membrane integral component of membrane uc008wvg.1 uc008wvg.2 
ENSMUST00000088132.13 Eya2 ENSMUST00000088132.13 EYA transcriptional coactivator and phosphatase 2, transcript variant 3 (from RefSeq NM_001271963.2) A2A5S4 ENSMUST00000088132.1 ENSMUST00000088132.10 ENSMUST00000088132.11 ENSMUST00000088132.12 ENSMUST00000088132.2 ENSMUST00000088132.3 ENSMUST00000088132.4 ENSMUST00000088132.5 ENSMUST00000088132.6 ENSMUST00000088132.7 ENSMUST00000088132.8 ENSMUST00000088132.9 EYA2_MOUSE Eab1 NM_001271963 O08575 P97925 uc008nxw.1 uc008nxw.2 uc008nxw.3 uc008nxw.4 This gene encodes a member of the eyes absent protein family. The encoded protein is a tyrosine phosphatase which acts as a transcriptional activator during development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:10490620, PubMed:17098221). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Probably interacts with SIX2, SIX4 and SIX5. Interacts with DACH2. Interacts with GNAZ and GNAI2; this retains EYA2 in the cytoplasm and prevents its translocation into the nucleus and transcriptional activity (By similarity). Interacts with SIX1. Interacts with CAPN8. O08575; Q91WA6: Sharpin; NbExp=2; IntAct=EBI-986503, EBI-646097; Cytoplasm Nucleus Note=Retained in the cytoplasm via interaction with GNAZ and GNAI2 (By similarity). Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O08575-1; Sequence=Displayed; Name=2; IsoId=O08575-2; Sequence=VSP_001492; Extensively expressed in cranial placodes, branchial arches, CNS and developing eye and nose. Low expression in lung with little or no expression in skin, liver, intestine and kidney. Predominantly expressed in the upper one-third of the oxyntic mucosa and in most regions of the pyloric mucosa. No visible phenotype. In contrast, mice lacking both Eya1 and Eya2 display complete embryonic lethality, due to severe defects in muscle development, including the absence of the diaphragm, the absence of ventral hypaxial muscles of the trunk and muscles in forelimbs and hindlimbs, similar to the phenotype of mice lacking both Six1 and Six4. While Six1 is normally expressed in these mice, it does not activate transcription from cognate promoter elements, and does not activate transcription of Pax3. Belongs to the HAD-like hydrolase superfamily. EYA family. magnesium ion binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding nucleus cytoplasm mitochondrion cytosol DNA repair chromatin organization protein dephosphorylation cellular response to DNA damage stimulus multicellular organism development transcription factor binding striated muscle tissue development histone dephosphorylation hydrolase activity peptidyl-tyrosine dephosphorylation positive regulation of DNA repair metal ion binding anatomical structure development extrinsic apoptotic signaling pathway in absence of ligand mitochondrial outer membrane permeabilization negative regulation of extrinsic apoptotic signaling pathway in absence of ligand nucleolus uc008nxw.1 uc008nxw.2 uc008nxw.3 uc008nxw.4 
ENSMUST00000088133.5 BC061195 ENSMUST00000088133.5 cDNA sequence BC061195 (from RefSeq NR_105038.1) ENSMUST00000088133.1 ENSMUST00000088133.2 ENSMUST00000088133.3 ENSMUST00000088133.4 NR_105038 uc012hlx.1 uc012hlx.2 uc012hlx.3 uc012hlx.4 uc012hlx.1 uc012hlx.2 uc012hlx.3 uc012hlx.4 
ENSMUST00000088134.5 1700003E24Rik ENSMUST00000088134.5 1700003E24Rik (from geneSymbol) BC061195 ENSMUST00000088134.1 ENSMUST00000088134.2 ENSMUST00000088134.3 ENSMUST00000088134.4 uc012hlw.1 uc012hlw.2 uc012hlw.3 uc012hlw.4 uc012hlw.5 uc012hlw.1 uc012hlw.2 uc012hlw.3 uc012hlw.4 uc012hlw.5 
ENSMUST00000088142.6 Tmt1a2 ENSMUST00000088142.6 thiol methyltransferase 1A2 (from RefSeq NM_199477.2) ENSMUST00000088142.1 ENSMUST00000088142.2 ENSMUST00000088142.3 ENSMUST00000088142.4 ENSMUST00000088142.5 Mettl7a2 NM_199477 Q5I0W6 Q5I0W6_MOUSE Tmt1a2 UbiE3 uc007xqy.1 uc007xqy.2 uc007xqy.3 methyltransferase activity membrane integral component of membrane transferase activity methylation uc007xqy.1 uc007xqy.2 uc007xqy.3 
ENSMUST00000088146.3 Ppp4r3c1 ENSMUST00000088146.3 protein phosphatase 4 regulatory subunit 3C1 (from RefSeq NM_001033880.3) A2AG62 ENSMUST00000088146.1 ENSMUST00000088146.2 NM_001033880 P4R3C_MOUSE Ppp4r3c Ppp4r3cp Q3V0Y1 Smek3p uc012hlr.1 uc012hlr.2 uc012hlr.3 Belongs to the SMEK family. molecular_function cellular_component biological_process uc012hlr.1 uc012hlr.2 uc012hlr.3 
ENSMUST00000088169.7 Rtn3 ENSMUST00000088169.7 reticulon 3, transcript variant 4 (from RefSeq NM_053076.3) ENSMUST00000088169.1 ENSMUST00000088169.2 ENSMUST00000088169.3 ENSMUST00000088169.4 ENSMUST00000088169.5 ENSMUST00000088169.6 NM_053076 Q3UF62 Q544J1 Q68FE4 Q6IM69 Q6R8K6 Q6R8K7 Q6T929 Q8C6D5 Q8CCU2 Q9ES97 RTN3_MOUSE uc033hiw.1 uc033hiw.2 uc033hiw.3 uc033hiw.4 May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress (PubMed:24262037). Induces the formation of endoplasmic reticulum tubules. Acts also as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition (By similarity). Homodimer. Interacts with RTN4. Isoform 3 interacts with BACE1, BACE2, BCL2 and FADD (By similarity). Interacts with ATL1 and ATL2 (PubMed:19665976). Isoform 3 interacts with TMEM33 (PubMed:25612671). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27- dependent manner (By similarity). Interacts with RIGI (By similarity). Interacts with TRIM25 (By similarity). Q9ES97-3; Q8WXF7: ATL1; Xeno; NbExp=3; IntAct=EBI-1487798, EBI-2410266; Q9ES97-3; Q8NHH9: ATL2; Xeno; NbExp=2; IntAct=EBI-1487798, EBI-2410430; Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=A1, A4b, B; IsoId=Q9ES97-1; Sequence=Displayed; Name=2; Synonyms=A2, A3b; IsoId=Q9ES97-2; Sequence=VSP_023763; Name=3; Synonyms=B1, A1, Rtn3c; IsoId=Q9ES97-3; Sequence=VSP_023762; Name=4; Synonyms=B2, A2; IsoId=Q9ES97-4; Sequence=VSP_023764; Name=5; Synonyms=A4a; IsoId=Q9ES97-5; Sequence=VSP_023765; Isoform 1, isoform 3, isoform 4 and isoform 5 are expressed in spinal cord. Isoform 1 is present in brain, where it is expressed in the neurons of cerebral cortex, hippocampus, hypothalamus and cerebellum (at protein level). Golgi membrane protein binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus apoptotic process membrane integral component of membrane vesicle-mediated transport synapse endoplasmic reticulum tubular network organization endoplasmic reticulum tubular network assembly uc033hiw.1 uc033hiw.2 uc033hiw.3 uc033hiw.4 
ENSMUST00000088174.4 Hs6st1 ENSMUST00000088174.4 heparan sulfate 6-O-sulfotransferase 1 (from RefSeq NM_015818.2) ENSMUST00000088174.1 ENSMUST00000088174.2 ENSMUST00000088174.3 H6ST1_MOUSE Hs6st1 NM_015818 Q3TK52 Q3TKK0 Q3TND4 Q3TZT5 Q9QYK5 uc007apn.1 uc007apn.2 uc007apn.3 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:56604, Rhea:RHEA- COMP:9830, Rhea:RHEA-COMP:14621, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:140604; Evidence=; Kinetic parameters: KM=10 uM for CDSNS-heparin ; KM=100 uM for NS-heparosan ; Membrane ; Single-pass type II membrane protein Expressed in fetal brain and liver. N-glycosylated. According to PubMed:17405882 most mice die between embryonic day 15.5 and the perinatal stage. Those that survive are considerably smaller than their wild-type littermates and exhibit development abnormalities including a reduction in the number of fetal microvessels in the labyrinthine zone of the placenta. However, according to PubMed:18196599, pups are viable and grossly normal at birth. During early adulthood, however, mice fail to thrive and exhibit growth retardation, bodyweight loss, enlargement of airspaces in the lung and, in some cases, lethality. Belongs to the sulfotransferase 6 family. Sequence=AAH52316.1; Type=Erroneous initiation; Evidence=; Sequence=BAA89248.1; Type=Erroneous initiation; Evidence=; angiogenesis sulfotransferase activity heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, enzymatic modification membrane integral component of membrane transferase activity heparan sulfate 6-O-sulfotransferase activity lung alveolus development neuron development labyrinthine layer blood vessel development uc007apn.1 uc007apn.2 uc007apn.3 
ENSMUST00000088198.4 Obp1b ENSMUST00000088198.4 odorant binding protein IB (from RefSeq NM_001310328.1) A2AEP0 ENSMUST00000088198.1 ENSMUST00000088198.2 ENSMUST00000088198.3 NM_001310328 OBP1B_MOUSE Obp1b P97337 uc057asa.1 uc057asa.2 uc057asa.3 Binds the chemical odorant 2-isobutyl-3-methoxypyrazine. May form a heterodimer with OBP1A. Secreted Expressed in nasal mucosa (at protein level) (PubMed:8529023). Specifically detected in septal and lateral nasal glands (PubMed:9661663). The N-terminus may be blocked. Belongs to the calycin superfamily. Lipocalin family. cellular_component extracellular region sensory perception of smell biological_process small molecule binding response to stimulus uc057asa.1 uc057asa.2 uc057asa.3 
ENSMUST00000088201.2 Obp1a ENSMUST00000088201.2 odorant binding protein IA (from RefSeq NM_008754.2) ENSMUST00000088201.1 NM_008754 OBP1A_MOUSE Obp1a P97336 Q9D3H2 uc009tqu.1 uc009tqu.2 Binds the chemical odorant 2-isobutyl-3-methoxypyrazine. May form a heterodimer with OBP1B. Secreted Expressed in nasal mucosa (at protein level) (PubMed:8529023). Specifically detected in septal and lateral nasal glands (PubMed:9661663). The N-terminus may be blocked. Belongs to the calycin superfamily. Lipocalin family. odorant binding cellular_component extracellular region sensory perception of smell biological_process small molecule binding response to stimulus uc009tqu.1 uc009tqu.2 
ENSMUST00000088217.12 Tbl1x ENSMUST00000088217.12 transducin (beta)-like 1 X-linked, transcript variant 2 (from RefSeq NM_020601.3) ENSMUST00000088217.1 ENSMUST00000088217.10 ENSMUST00000088217.11 ENSMUST00000088217.2 ENSMUST00000088217.3 ENSMUST00000088217.4 ENSMUST00000088217.5 ENSMUST00000088217.6 ENSMUST00000088217.7 ENSMUST00000088217.8 ENSMUST00000088217.9 NM_020601 Q8BMM0 Q8BYQ4 Q8C0A1 Q9QXE7 TBL1X_MOUSE Tbl1 uc009tqo.1 uc009tqo.2 uc009tqo.3 F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity). Homotetramer; dimer of dimers (By similarity). Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with GPS2 (when sumoylated); leading to protect GPS2 against degradation by the proteasome (PubMed:26070566). Probably part of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4 (By similarity). Interacts with MECP2; recruits TBL1X to the heterochromatin foci (PubMed:28348241). Interacts with USP44 (By similarity). Q9QXE7; P51608: MECP2; Xeno; NbExp=3; IntAct=EBI-8821270, EBI-1189067; Nucleus Note=Colocalized with MECP2 to the heterochromatin foci. Expressed in the cochlea. The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes. Belongs to the WD repeat EBI family. Sequence=CAB61534.1; Type=Erroneous gene model prediction; Evidence=; histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter DNA binding chromatin binding transcription corepressor activity protein binding nucleus nucleoplasm transcription factor complex regulation of transcription from RNA polymerase II promoter proteolysis sensory perception of sound beta-catenin binding protein C-terminus binding transcription factor binding histone deacetylation transcriptional repressor complex protein domain specific binding histone binding identical protein binding proteasome-mediated ubiquitin-dependent protein catabolic process response to estrogen transcription regulatory region DNA binding fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to steroid hormone protein stabilization mitotic spindle positive regulation of canonical Wnt signaling pathway uc009tqo.1 uc009tqo.2 uc009tqo.3 
ENSMUST00000088223.7 Trpt1 ENSMUST00000088223.7 tRNA phosphotransferase 1, transcript variant 1 (from RefSeq NM_153597.2) ENSMUST00000088223.1 ENSMUST00000088223.2 ENSMUST00000088223.3 ENSMUST00000088223.4 ENSMUST00000088223.5 ENSMUST00000088223.6 NM_153597 Q8K3A2 TRPT1_MOUSE Tpt1h uc008gka.1 uc008gka.2 uc008gka.3 uc008gka.4 uc008gka.5 Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP- ribose 1''-2'' cyclic phosphate. Reaction=2'-phospho-[ligated tRNA] + NAD(+) = ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide; Xref=Rhea:RHEA:23324, Rhea:RHEA-COMP:11106, Rhea:RHEA-COMP:11107, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:76596, ChEBI:CHEBI:82883, ChEBI:CHEBI:85027; EC=2.7.1.160; Evidence=; Belongs to the KptA/TPT1 family. Sequence=AAH27575.1; Type=Erroneous initiation; Evidence=; tRNA 2'-phosphotransferase activity cellular_component tRNA splicing, via endonucleolytic cleavage and ligation tRNA processing transferase activity transferase activity, transferring phosphorus-containing groups regulation of protein kinase activity uc008gka.1 uc008gka.2 uc008gka.3 uc008gka.4 uc008gka.5 
ENSMUST00000088236.5 Gm10220 ENSMUST00000088236.5 predicted gene 10220 (from RefSeq NM_001134299.1) ENSMUST00000088236.1 ENSMUST00000088236.2 ENSMUST00000088236.3 ENSMUST00000088236.4 Gm10220 K7N660 K7N660_MOUSE NM_001134299 uc012dto.1 uc012dto.2 uc012dto.3 molecular_function cellular_component biological_process uc012dto.1 uc012dto.2 uc012dto.3 
ENSMUST00000088237.6 Nanos1 ENSMUST00000088237.6 nanos C2HC-type zinc finger 1 (from RefSeq NM_178421.3) ENSMUST00000088237.1 ENSMUST00000088237.2 ENSMUST00000088237.3 ENSMUST00000088237.4 ENSMUST00000088237.5 NANO1_MOUSE NM_178421 Nos Q3UTS9 Q80WY3 Q8BIJ9 uc008ibw.1 uc008ibw.2 uc008ibw.3 uc008ibw.4 This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2and may be involved in regulating translation as a post-transcriptional repressor. Mutations in a similar protein in human are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion (By similarity). Not essential for normal development. Interacts with PUM2, SNAPIN and CTNNB1. Interacts (via N- terminal region) with CTNND1. Interacts with DDX20 (via N-terminal region) (By similarity). Cytoplasm, perinuclear region Cytoplasm Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. Expressed in the oocyte. Transiently expressed in eight-cell embryos. At 12.5 dpc, it is re-expressed in the central nervous system and the expression continues in the adult brain, in which the hippocampal formation is the predominant region. Expressed in the seminiferous tubules of mature testis, but not in the primordial germ cells. Expressed both maternally and zygotically. The N-terminal region and C-terminal zinc-finger RNA-binding domain are both necessary for interaction with SNAPIN. The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein. Belongs to the nanos family. Sequence=BAC76003.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; regulation of cell growth tissue homeostasis molecular_function RNA binding cytoplasm regulation of translation zinc ion binding posttranscriptional regulation of gene expression epithelial cell migration cell migration negative regulation of translation translation repressor activity metal ion binding perinuclear region of cytoplasm cerebellar neuron development positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay uc008ibw.1 uc008ibw.2 uc008ibw.3 uc008ibw.4 
ENSMUST00000088244.6 Actr3b ENSMUST00000088244.6 ARP3 actin-related protein 3B, transcript variant 12 (from RefSeq NR_188892.1) ARP3B_MOUSE ENSMUST00000088244.1 ENSMUST00000088244.2 ENSMUST00000088244.3 ENSMUST00000088244.4 ENSMUST00000088244.5 NR_188892 Q641P0 Q7TSH1 uc008wtc.1 uc008wtc.2 uc008wtc.3 uc008wtc.4 Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors (By similarity). Interacts with the Arp2/3 complex composed of ARP2, ARP3, ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Cytoplasm, cytoskeleton Cell projection Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q641P0-1; Sequence=Displayed; Name=2; IsoId=Q641P0-2; Sequence=VSP_034419; Belongs to the actin family. ARP3 subfamily. nucleotide binding actin binding ATP binding cytoplasm cytoskeleton Arp2/3 protein complex actin filament organization biological_process Arp2/3 complex-mediated actin nucleation cell projection actin filament binding uc008wtc.1 uc008wtc.2 uc008wtc.3 uc008wtc.4 
ENSMUST00000088246.6 Tuba3a ENSMUST00000088246.6 tubulin, alpha 3A (from RefSeq NM_009446.3) ENSMUST00000088246.1 ENSMUST00000088246.2 ENSMUST00000088246.3 ENSMUST00000088246.4 ENSMUST00000088246.5 NM_009446 Q5FW91 Q5FW91_MOUSE Tuba3a uc009dui.1 uc009dui.2 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Belongs to the tubulin family. nucleotide binding GTPase activity structural constituent of cytoskeleton GTP binding cytoplasm cytoskeleton microtubule cytoskeleton organization microtubule-based process uc009dui.1 uc009dui.2 
ENSMUST00000088248.13 Ube2c ENSMUST00000088248.13 ubiquitin-conjugating enzyme E2C (from RefSeq NM_026785.2) ENSMUST00000088248.1 ENSMUST00000088248.10 ENSMUST00000088248.11 ENSMUST00000088248.12 ENSMUST00000088248.2 ENSMUST00000088248.3 ENSMUST00000088248.4 ENSMUST00000088248.5 ENSMUST00000088248.6 ENSMUST00000088248.7 ENSMUST00000088248.8 ENSMUST00000088248.9 NM_026785 Q3TUJ0 Q9D1C1 UBE2C_MOUSE Ubch10 uc008nvy.1 uc008nvy.2 uc008nvy.3 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence= Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L- cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.24; Evidence=; Protein modification; protein ubiquitination. Component of the APC/C complex, composed of at least 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Within this complex, directly interacts with ANAPC2. Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed. Belongs to the ubiquitin-conjugating enzyme family. ubiquitin ligase complex nucleotide binding ubiquitin-protein transferase activity ATP binding nucleus anaphase-promoting complex cytosol plasma membrane ubiquitin-dependent protein catabolic process cell cycle exit from mitosis free ubiquitin chain polymerization protein ubiquitination transferase activity anaphase-promoting complex-dependent catabolic process positive regulation of exit from mitosis ubiquitin-like protein ligase binding cell division ubiquitin conjugating enzyme activity protein K48-linked ubiquitination protein K11-linked ubiquitination uc008nvy.1 uc008nvy.2 uc008nvy.3 
ENSMUST00000088257.14 Trmt112 ENSMUST00000088257.14 tRNA methyltransferase 11-2, transcript variant 2 (from RefSeq NM_026306.3) ENSMUST00000088257.1 ENSMUST00000088257.10 ENSMUST00000088257.11 ENSMUST00000088257.12 ENSMUST00000088257.13 ENSMUST00000088257.2 ENSMUST00000088257.3 ENSMUST00000088257.4 ENSMUST00000088257.5 ENSMUST00000088257.6 ENSMUST00000088257.7 ENSMUST00000088257.8 ENSMUST00000088257.9 NM_026306 Q91YP8 Q9D1N6 Q9DCG9 TR112_MOUSE uc008gjd.1 uc008gjd.2 uc008gjd.3 uc008gjd.4 uc008gjd.5 Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:20606008, PubMed:26797129). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (By similarity). The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:20606008, PubMed:26797129). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (By similarity). Together with methyltransferase THUMPD3, catalyzes the formation of N(2)- methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp) (By similarity). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (By similarity). Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (By similarity). Heterodimer with BUD23/WBSCR22; this heterodimerization is necessary for the metabolic stability and activity of the catalytic subunit BUD23 (By similarity). Heterodimer with N6AMT1/HEMK2; this heterodimerization is necessary for S-adenosyl-L-methionine-binding to N6AMT1/HEMK2 (PubMed:26797129). Heterodimer with ALKBH8 (By similarity). Heterodimer with METTL5; this heterodimerization is necessary for the stability of the catalytic subunit METTL5 (By similarity). Interacts with THUMPD3; the interaction is direct and is required for THUMPD3 methyltransferase activity (By similarity). Interacts with THUMPD2 (By similarity). Nucleus, nucleoplasm Cytoplasm, perinuclear region Note=Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes. Abundantly expressed in the testis, also expressed in the brain, heart, kidney, liver, lung, muscle and spleen. Belongs to the TRM112 family. protein binding nucleus nucleoplasm cytoplasm protein methyltransferase activity rRNA (guanine) methyltransferase activity peptidyl-glutamine methylation tRNA methylation macromolecular complex protein heterodimerization activity perinuclear region of cytoplasm rRNA (guanine-N7)-methylation positive regulation of rRNA processing uc008gjd.1 uc008gjd.2 uc008gjd.3 uc008gjd.4 uc008gjd.5 
ENSMUST00000088260.2 Wfdc13 ENSMUST00000088260.2 WAP four-disulfide core domain 13 (from RefSeq NM_001012704.1) ENSMUST00000088260.1 NM_001012704 Q5DQQ6 Q6IE33 WFD13_MOUSE Wfdc13l1 uc008nvq.1 uc008nvq.2 Putative acid-stable proteinase inhibitor. Secreted molecular_function serine-type endopeptidase inhibitor activity cellular_component extracellular region biological_process negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc008nvq.1 uc008nvq.2 
ENSMUST00000088287.10 Rab23 ENSMUST00000088287.10 RAB23, member RAS oncogene family, transcript variant 1 (from RefSeq NM_008999.5) ENSMUST00000088287.1 ENSMUST00000088287.2 ENSMUST00000088287.3 ENSMUST00000088287.4 ENSMUST00000088287.5 ENSMUST00000088287.6 ENSMUST00000088287.7 ENSMUST00000088287.8 ENSMUST00000088287.9 NM_008999 Q9D4I9 Q9D4I9_MOUSE Rab23 uc007anw.1 uc007anw.2 uc007anw.3 uc007anw.4 Belongs to the small GTPase superfamily. Rab family. autophagosome assembly nucleotide binding GTPase activity GTP binding cytoplasm autophagosome centrosome cytosol plasma membrane cellular defense response signal transduction membrane cell junction negative regulation of protein import into nucleus phagocytic vesicle GTP metabolic process cilium assembly craniofacial suture morphogenesis uc007anw.1 uc007anw.2 uc007anw.3 uc007anw.4 
ENSMUST00000088292.7 Lpar5 ENSMUST00000088292.7 lysophosphatidic acid receptor 5, transcript variant 2 (from RefSeq NM_001163269.2) ENSMUST00000088292.1 ENSMUST00000088292.2 ENSMUST00000088292.3 ENSMUST00000088292.4 ENSMUST00000088292.5 ENSMUST00000088292.6 Gm1072 Gpr92 LPAR5_MOUSE NM_001163269 Q149R9 Q3V2G2 Q80T30 uc009dtj.1 uc009dtj.2 Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane positive regulation of CREB transcription factor activity behavioral response to pain uc009dtj.1 uc009dtj.2 
ENSMUST00000088294.12 Acrbp ENSMUST00000088294.12 proacrosin binding protein, transcript variant 1 (from RefSeq NM_016845.2) ACRBP_MOUSE Acrbp ENSMUST00000088294.1 ENSMUST00000088294.10 ENSMUST00000088294.11 ENSMUST00000088294.2 ENSMUST00000088294.3 ENSMUST00000088294.4 ENSMUST00000088294.5 ENSMUST00000088294.6 ENSMUST00000088294.7 ENSMUST00000088294.8 ENSMUST00000088294.9 NM_016845 Q3V140 Q62253 Q62254 Q8C621 Q91VQ1 uc009dti.1 uc009dti.2 uc009dti.3 uc009dti.4 Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation. [Acrosin-binding protein, mature form]: Maintains pro-ACR as an enzymatically inactive zymogen in the acrosome until acrosomal exocytosis (PubMed:27303034). Partially contributes also to the assembly of acrosomal proteins to form an acrosomal granule (PubMed:27303034). [Isoform 2]: Rodent specific isoform that participates in the formation of the acrosomal granule into the center of the acrosomal vesicle during early spermiogenesis (PubMed:27303034). In the fertilization process promotes ACR release from the acrosome during acrosomal exocytosis (PubMed:27303034). [Acrosin-binding protein, mature form]: Binds pro-ACR. Does not bind the mature form of ACR. [Isoform 2]: Binds pro-ACR. Does not bind the mature form of ACR. [Isoform 2]: Cytoplasmic vesicle, secretory vesicle, acrosome Note=Colocalized with pro-ACR in the acrosomal granules of early round spermatids. [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome creted Note=Highly enriched in acrosomal granules of round spermatids, and spread over the apical end of the nucleus in elongating spermatids. Colocalized in the acrosome of epididymal sperm with pro-ACR. Event=Alternative splicing; Named isoforms=2; Name=1 ; Synonyms=ACRBP-W ; IsoId=Q3V140-1; Sequence=Displayed; Name=2 ; Synonyms=ACRBP-V5 ; IsoId=Q3V140-2; Sequence=VSP_051965, VSP_051966; [Isoform 1]: Testis-specific (at protein level). Detected in pachytene spermatocytes and in haploid spermatids and in elongating spermatids. [Isoform 2]: Testis-specific. Detected in pachytene spermatocytes and round spermatids but absent in elongating spermatids. Produced specifically in rodents. The N-terminus is blocked. Phosphorylated on Tyr residues in capacitated sperm. [Isoform 1]: Synthesized as a 60-kDa precursor in pachytene spermatocytes, postmeiotic spermatocytes and haploid spermatids and is processed into the mature protein in elongating spermatids. [Isoform 2]: Degraded in elongating spermatid. Deficient male and female are normal in behavior, body size, and health condition. Females exhibit normal fertility. However, males exhibit a severely reduced fertility. The acrosomal structure of spermatids is severely deformed at the later steps of spermiogenesis. acrosomal vesicle acrosome assembly acrosomal membrane protein binding extracellular region spermatid development fertilization positive regulation of peptidase activity peptidase activator activity cytoplasmic vesicle uc009dti.1 uc009dti.2 uc009dti.3 uc009dti.4 
ENSMUST00000088295.9 Chpf2 ENSMUST00000088295.9 chondroitin polymerizing factor 2, transcript variant 2 (from RefSeq NR_155297.1) Chpf2 ENSMUST00000088295.1 ENSMUST00000088295.2 ENSMUST00000088295.3 ENSMUST00000088295.4 ENSMUST00000088295.5 ENSMUST00000088295.6 ENSMUST00000088295.7 ENSMUST00000088295.8 NR_155297 Q3UU43 Q3UU43_MOUSE uc012dte.1 uc012dte.2 uc012dte.3 Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the chondroitin N- acetylgalactosaminyltransferase family. molecular_function Golgi apparatus biological_process acetylgalactosaminyltransferase activity transferase activity Golgi cisterna membrane uc012dte.1 uc012dte.2 uc012dte.3 
ENSMUST00000088302.10 Iqca1l ENSMUST00000088302.10 IQ motif containing with AAA domain 1 like, transcript variant 1 (from RefSeq NM_177676.6) A6H690 B9EHI7 E9QN17 ENSMUST00000088302.1 ENSMUST00000088302.2 ENSMUST00000088302.3 ENSMUST00000088302.4 ENSMUST00000088302.5 ENSMUST00000088302.6 ENSMUST00000088302.7 ENSMUST00000088302.8 ENSMUST00000088302.9 IQCAL_MOUSE Iqca1p1 NM_177676 Q8CDM7 uc012dtc.1 uc012dtc.2 uc012dtc.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A6H690-1; Sequence=Displayed; Name=2; IsoId=A6H690-2; Sequence=VSP_034231; Belongs to the AAA ATPase family. Sequence=BAC26640.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC26640.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; nucleotide binding molecular_function ATP binding biological_process uc012dtc.1 uc012dtc.2 uc012dtc.3 
ENSMUST00000088307.5 Uqcc4 ENSMUST00000088307.5 ubiquinol-cytochrome c reductase complex assembly factor 4 (from RefSeq NM_183150.2) Ccsmst1 ENSMUST00000088307.1 ENSMUST00000088307.2 ENSMUST00000088307.3 ENSMUST00000088307.4 NM_183150 Q6RUT7 UQCC4_MOUSE uc012amz.1 uc012amz.2 uc012amz.3 Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation. Forms a complex, named COMB/coordinator of mitochondrial CYTB biogenesis, composed of UQCC1, UQCC2, UQCC4, UQCC5 and UQCC6; stabilizes nascent cytochrome b/MT-CYB and promotes its membrane insertion (PubMed:35977508). Forms a complex, named COMA, composed of UQCC1, UQCC2 and UQCC4; activates MT-CYB translation (PubMed:35977508). Forms a complex, named COMC, composed of UQCC1, UQCC2; UQCC3 and UQCC4; mediates MT-CYB hemylation and association with the first nuclear- encoded complex III subunit UQCRQ (PubMed:35977508). Complexes COMA and COMB are bound to the mitochondrion inner membrane by UQCC4 (PubMed:35977508). Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the UQCC4 family. molecular_function cellular_component biological_process membrane integral component of membrane uc012amz.1 uc012amz.2 uc012amz.3 
ENSMUST00000088311.6 Gbx1 ENSMUST00000088311.6 gastrulation brain homeobox 1 (from RefSeq NM_015739.2) ENSMUST00000088311.1 ENSMUST00000088311.2 ENSMUST00000088311.3 ENSMUST00000088311.4 ENSMUST00000088311.5 GBX1_MOUSE NM_015739 P82976 Q8CGW5 uc008wrx.1 uc008wrx.2 uc008wrx.3 Nucleus Expressed in CNS including rhombomeres 3 and 5, optic vesicles, and the medial ganglionic eminence. Expressed first during gastrulation and later in a dynamic pattern in the central nervous system. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus regulation of transcription, DNA-templated adult walking behavior proprioception spinal cord motor neuron differentiation cerebellum development hindbrain development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter neuron fate commitment regulation of nervous system development sensory neuron axon guidance uc008wrx.1 uc008wrx.2 uc008wrx.3 
ENSMUST00000088357.12 Atn1 ENSMUST00000088357.12 atrophin 1 (from RefSeq NM_007881.4) ATN1_MOUSE Drpla ENSMUST00000088357.1 ENSMUST00000088357.10 ENSMUST00000088357.11 ENSMUST00000088357.2 ENSMUST00000088357.3 ENSMUST00000088357.4 ENSMUST00000088357.5 ENSMUST00000088357.6 ENSMUST00000088357.7 ENSMUST00000088357.8 ENSMUST00000088357.9 NM_007881 O35126 P70200 Q80YQ0 uc009drr.1 uc009drr.2 uc009drr.3 Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of the poly-Q repeats (By similarity). Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. Interacts with BAIAP2, WWP1, WWP2, WWP3 and RERE. Interacts (via its N-terminus) with MTG8; the interaction enhances transcriptional repression of MTG8. Interacts with PQBP1 (By similarity). Interacts with NR2E1; the interaction represses the transcriptional activity of NR2E1. Interacts with FAT1 (via a C- terminal domain). Cytoplasm, perinuclear region Cell junction Nucleus Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells. Colocalizes with MTG8 in discrete nuclear dots (By similarity). Widely expressed. Most abundant in the brain. Expressed as early as 5 days and thereafter shows little variation throughout 17 days. In vascular smooth muscle, induced by angiotensin II, FGF; PGF and IL1B. Phosphorylated in vitro by MAPK8/JNK1 on Ser-724. The poly-Gln region of Atn1 is polymorphic (3 to 8 repeats). The mouse model of DRPLA with 129 CAG repeats (Q129) exhibited severe neurological defects similar to those of juvenile- onset DRPLA patients including age-dependent and region-specific presynaptic dysfunction in the globus pallidus and cerebellum. Progressive shrinkage of distal dendrites of Purkinje cells and decreased currents through alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid and gamma-aminobutyrate type A receptors in CA1 neurons was observed. There is progressive brain atrophy. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding DNA binding transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm cytoplasm spermatogenesis determination of adult lifespan JUN kinase binding male gonad development toxin metabolic process pathogenesis post-embryonic development nuclear matrix cell migration protein domain specific binding maintenance of cell polarity cell junction cell leading edge response to food multicellular organism growth perinuclear region of cytoplasm neuron apoptotic process toxin activity positive regulation of nucleic acid-templated transcription uc009drr.1 uc009drr.2 uc009drr.3 
ENSMUST00000088373.11 Srgap3 ENSMUST00000088373.11 SLIT-ROBO Rho GTPase activating protein 3 (from RefSeq NM_080448.4) ENSMUST00000088373.1 ENSMUST00000088373.10 ENSMUST00000088373.2 ENSMUST00000088373.3 ENSMUST00000088373.4 ENSMUST00000088373.5 ENSMUST00000088373.6 ENSMUST00000088373.7 ENSMUST00000088373.8 ENSMUST00000088373.9 F8VPQ4 F8VPQ4_MOUSE NM_080448 Srgap3 uc009deh.1 uc009deh.2 uc009deh.3 GTPase activator activity signal transduction positive regulation of GTPase activity uc009deh.1 uc009deh.2 uc009deh.3 
ENSMUST00000088386.8 Slc15a1 ENSMUST00000088386.8 solute carrier family 15 (oligopeptide transporter), member 1 (from RefSeq NM_053079.2) E9QMX3 ENSMUST00000088386.1 ENSMUST00000088386.2 ENSMUST00000088386.3 ENSMUST00000088386.4 ENSMUST00000088386.5 ENSMUST00000088386.6 ENSMUST00000088386.7 NM_053079 Pept1 Q9JIP7 S15A1_MOUSE Slc15a1 uc007vad.1 uc007vad.2 uc007vad.3 Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1 (PubMed:11004485) (By similarity). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system (By similarity). Reaction=a dipeptide(out) + H(+)(out) = a dipeptide(in) + H(+)(in); Xref=Rhea:RHEA:64392, ChEBI:CHEBI:15378, ChEBI:CHEBI:90799; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64393; Evidence=; Reaction=an L-amino acid tripeptide(out) + H(+)(out) = an L-amino acid tripeptide(in) + H(+)(in); Xref=Rhea:RHEA:64400, ChEBI:CHEBI:15378, ChEBI:CHEBI:155837; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64401; Evidence=; Reaction=H(+)(out) + L-alanyl-L-lysine(out) = H(+)(in) + L-alanyl-L- lysine(in); Xref=Rhea:RHEA:72611, ChEBI:CHEBI:15378, ChEBI:CHEBI:192470; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72612; Evidence=; Reaction=H(+)(out) + L-alanyl-L-proline(out) = H(+)(in) + L-alanyl-L- proline(in); Xref=Rhea:RHEA:64420, ChEBI:CHEBI:15378, ChEBI:CHEBI:155848; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64421; Evidence=; Reaction=H(+)(out) + L-alanyl-L-valine(out) = H(+)(in) + L-alanyl-L- valine(in); Xref=Rhea:RHEA:72615, ChEBI:CHEBI:15378, ChEBI:CHEBI:192471; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72616; Evidence=; Reaction=carnosine(out) + H(+)(out) = carnosine(in) + H(+)(in); Xref=Rhea:RHEA:64404, ChEBI:CHEBI:15378, ChEBI:CHEBI:57485; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64405; Evidence=; Reaction=glycyl-L-glutamine(out) + H(+)(out) = glycyl-L-glutamine(in) + H(+)(in); Xref=Rhea:RHEA:71671, ChEBI:CHEBI:15378, ChEBI:CHEBI:74392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71672; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71673; Evidence=; Reaction=glycyl-L-leucine(out) + H(+)(out) = glycyl-L-leucine(in) + H(+)(in); Xref=Rhea:RHEA:71675, ChEBI:CHEBI:15378, ChEBI:CHEBI:143163; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71676; Evidence=; Reaction=glycyl-L-proline(out) + H(+)(out) = glycyl-L-proline(in) + H(+)(in); Xref=Rhea:RHEA:64428, ChEBI:CHEBI:15378, ChEBI:CHEBI:73779; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64429; Evidence=; Reaction=glycyl-sarcosine(out) + H(+)(out) = glycyl-sarcosine(in) + H(+)(in); Xref=Rhea:RHEA:64396, ChEBI:CHEBI:15378, ChEBI:CHEBI:155838; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64397; Evidence=; Reaction=H(+)(out) + L-leucyl-L-leucine(out) = H(+)(in) + L-leucyl-L- leucine(in); Xref=Rhea:RHEA:71715, ChEBI:CHEBI:15378, ChEBI:CHEBI:191208; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71716; Evidence=; Reaction=H(+)(out) + L-leucyl-L-proline(out) = H(+)(in) + L-leucyl-L- proline(in); Xref=Rhea:RHEA:64424, ChEBI:CHEBI:15378, ChEBI:CHEBI:155847; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64425; Evidence=; Reaction=H(+)(out) + L-phenylalanyl-L-leucine(out) = H(+)(in) + L- phenylalanyl-L-leucine(in); Xref=Rhea:RHEA:71699, ChEBI:CHEBI:15378, ChEBI:CHEBI:190710; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71700; Evidence=; Reaction=H(+)(out) + L-phenylalanyl-L-phenylalanine(out) = H(+)(in) + L-phenylalanyl-L-phenylalanine(in); Xref=Rhea:RHEA:71707, ChEBI:CHEBI:15378, ChEBI:CHEBI:191205; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71708; Evidence=; Reaction=H(+)(out) + L-lysyl-glycine(out) = H(+)(in) + L-lysyl- glycine(in); Xref=Rhea:RHEA:71679, ChEBI:CHEBI:15378, ChEBI:CHEBI:191202; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71680; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71681; Evidence=; Reaction=H(+)(out) + L-tyrosylglycine(out) = H(+)(in) + L- tyrosylglycine(in); Xref=Rhea:RHEA:71711, ChEBI:CHEBI:15378, ChEBI:CHEBI:191210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71712; Evidence=; Reaction=2 H(+)(out) + L-alanyl-L-aspartate(out) = 2 H(+)(in) + L- alanyl-L-aspartate(in); Xref=Rhea:RHEA:71695, ChEBI:CHEBI:15378, ChEBI:CHEBI:74363; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71696; Evidence= Reaction=2 H(+)(out) + L-aspartyl-glycine(out) = 2 H(+)(in) + L- aspartyl-glycine(in); Xref=Rhea:RHEA:71683, ChEBI:CHEBI:15378, ChEBI:CHEBI:191203; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71684; Evidence=; Reaction=glycyl-L-aspartate(out) + 2 H(+)(out) = glycyl-L-aspartate(in) + 2 H(+)(in); Xref=Rhea:RHEA:71687, ChEBI:CHEBI:15378, ChEBI:CHEBI:191204; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71688; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71689; Evidence=; Reaction=glycyl-L-glutamate(out) + 2 H(+)(out) = glycyl-L-glutamate(in) + 2 H(+)(in); Xref=Rhea:RHEA:71691, ChEBI:CHEBI:15378, ChEBI:CHEBI:73784; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71692; Evidence=; Reaction=H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) = H(+)(in) + L- alanyl-L-leucyl-L-alanine(in); Xref=Rhea:RHEA:71723, ChEBI:CHEBI:15378, ChEBI:CHEBI:191212; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71724; Evidence=; Reaction=H(+)(out) + L-alanyl-L-prolylglycine(out) = H(+)(in) + L- alanyl-L-prolylglycine(in); Xref=Rhea:RHEA:64432, ChEBI:CHEBI:15378, ChEBI:CHEBI:155849; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64433; Evidence=; Reaction=glycylglycyl-L-isoleucine(out) + H(+)(out) = glycylglycyl-L- isoleucine(in) + H(+)(in); Xref=Rhea:RHEA:64436, ChEBI:CHEBI:15378, ChEBI:CHEBI:155850; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64437; Evidence=; Reaction=glycylglycyl-L-proline(out) + H(+)(out) = glycylglycyl-L- proline(in) + H(+)(in); Xref=Rhea:RHEA:64440, ChEBI:CHEBI:15378, ChEBI:CHEBI:155851; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64441; Evidence=; Reaction=H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out) = H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in); Xref=Rhea:RHEA:71719, ChEBI:CHEBI:15378, ChEBI:CHEBI:191211; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71720; Evidence=; Reaction=2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = 2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in); Xref=Rhea:RHEA:64408, ChEBI:CHEBI:15378, ChEBI:CHEBI:155830; Evidence=; Reaction=2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L- phenylalanine(out) = 2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L- phenylalanine(in); Xref=Rhea:RHEA:75399, ChEBI:CHEBI:15378, ChEBI:CHEBI:194314; Evidence=; Interacts (via extracellular domain region) with trypsin. Apical cell membrane ; Multi-pass membrane protein Note=Localized to the apical membrane of enterocytes. The extracellular domain (ECD) region specifically binds trypsin. Belongs to the major facilitator superfamily. Proton- dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. proton-dependent oligopeptide secondary active transmembrane transporter activity integral component of plasma membrane brush border oligopeptide transport protein transport symporter activity peptide:proton symporter activity peptide transport membrane integral component of membrane channel inhibitor activity transmembrane transporter activity dipeptide transmembrane transport oligopeptide transmembrane transport oligopeptide transmembrane transporter activity negative regulation of amino acid transport transmembrane transport dipeptide transmembrane transporter activity hydrogen ion transmembrane transport peptide transmembrane transporter activity uc007vad.1 uc007vad.2 uc007vad.3 
ENSMUST00000088392.9 Srpk2 ENSMUST00000088392.9 serine/arginine-rich protein specific kinase 2, transcript variant 40 (from RefSeq NR_176379.1) A0A0R4J124 A0A0R4J124_MOUSE ENSMUST00000088392.1 ENSMUST00000088392.2 ENSMUST00000088392.3 ENSMUST00000088392.4 ENSMUST00000088392.5 ENSMUST00000088392.6 ENSMUST00000088392.7 ENSMUST00000088392.8 NR_176379 Srpk2 uc008wqe.1 uc008wqe.2 uc008wqe.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. spliceosomal complex assembly magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleoplasm nucleolus cytoplasm cytosol protein phosphorylation positive regulation of cell proliferation RNA splicing kinase activity phosphorylation intracellular signal transduction positive regulation of viral genome replication negative regulation of viral genome replication uc008wqe.1 uc008wqe.2 uc008wqe.3 
ENSMUST00000088407.4 Khdc1a ENSMUST00000088407.4 KH domain containing 1A (from RefSeq NM_183322.2) ENSMUST00000088407.1 ENSMUST00000088407.2 ENSMUST00000088407.3 KHD1A_MOUSE NM_183322 Ndg1 Q3UWR2 Q7TNM0 uc007aln.1 uc007aln.2 uc007aln.3 Has pro-apoptotic activity. Cytoplasm By NR4A1/NUR77. Belongs to the KHDC1 family. RNA binding protein binding cytoplasm apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process poly(U) RNA binding identical protein binding uc007aln.1 uc007aln.2 uc007aln.3 
ENSMUST00000088419.13 Mbnl2 ENSMUST00000088419.13 muscleblind like splicing factor 2, transcript variant 1 (from RefSeq NM_175341.4) ENSMUST00000088419.1 ENSMUST00000088419.10 ENSMUST00000088419.11 ENSMUST00000088419.12 ENSMUST00000088419.2 ENSMUST00000088419.3 ENSMUST00000088419.4 ENSMUST00000088419.5 ENSMUST00000088419.6 ENSMUST00000088419.7 ENSMUST00000088419.8 ENSMUST00000088419.9 Kiaa4072 MBNL2_MOUSE NM_175341 Q3TPH4 Q5DTQ0 Q8BUD8 Q8C181 uc007uzr.1 uc007uzr.2 uc007uzr.3 Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM) (By similarity). Interacts with ITGA3. Nucleus Cytoplasm Note=Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques. Location in the cytoplasm is microtubule-dependent. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8C181-1; Sequence=Displayed; Name=2; IsoId=Q8C181-2; Sequence=VSP_022890; Name=3; IsoId=Q8C181-3; Sequence=VSP_022889; Name=4; IsoId=Q8C181-4; Sequence=VSP_022891; Belongs to the muscleblind family. Sequence=BAD90497.1; Type=Erroneous initiation; Evidence=; regulation of alternative mRNA splicing, via spliceosome RNA binding nucleus nucleoplasm cytoplasm mRNA processing RNA splicing regulation of RNA splicing metal ion binding uc007uzr.1 uc007uzr.2 uc007uzr.3 
ENSMUST00000088429.8 Atp2b3 ENSMUST00000088429.8 ATPase, Ca++ transporting, plasma membrane 3, transcript variant 1 (from RefSeq NM_177236.4) Atp2b3 ENSMUST00000088429.1 ENSMUST00000088429.2 ENSMUST00000088429.3 ENSMUST00000088429.4 ENSMUST00000088429.5 ENSMUST00000088429.6 ENSMUST00000088429.7 NM_177236 Q0VF55 Q0VF55_MOUSE uc009tlz.1 uc009tlz.2 uc009tlz.3 uc009tlz.4 Catalyzes the hydrolysis of ATP coupled with the transport of calcium. Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.10; Evidence=; Membrane ulti-pass membrane protein Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. nucleotide binding calcium-transporting ATPase activity ATP binding Golgi apparatus plasma membrane ion transport calcium ion transport cellular calcium ion homeostasis calcium ion transmembrane transporter activity membrane integral component of membrane PDZ domain binding membrane raft regulation of cytosolic calcium ion concentration calcium ion transmembrane transport glutamatergic synapse GABA-ergic synapse integral component of presynaptic membrane regulation of presynaptic cytosolic calcium ion concentration calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration calcium ion export from cell uc009tlz.1 uc009tlz.2 uc009tlz.3 uc009tlz.4 
ENSMUST00000088448.12 Pkhd1 ENSMUST00000088448.12 polycystic kidney and hepatic disease 1 (from RefSeq NM_153179.3) E9PZ36 ENSMUST00000088448.1 ENSMUST00000088448.10 ENSMUST00000088448.11 ENSMUST00000088448.2 ENSMUST00000088448.3 ENSMUST00000088448.4 ENSMUST00000088448.5 ENSMUST00000088448.6 ENSMUST00000088448.7 ENSMUST00000088448.8 ENSMUST00000088448.9 NM_153179 PKHD1_MOUSE Pkhd1 uc007akv.1 uc007akv.2 uc007akv.3 Promotes ciliogenesis in renal epithelial cells and therefore participates in the tubules formation and/or ensures the maintenance of the architecture of the lumen of the kidney (PubMed:18235088, PubMed:20875407). Has an impact on cellular symmetry by ensuring correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly and by maintaining oriented cell division (OCD) during tubular elongation through planar cell polarity (PCP) pathway (PubMed:19959710). During epithelial cell morphogenesis regulates also cell-cell and cell-matrix adhesion and participates in cell motility (By similarity). Promotes cell-cell contact through the positive regulation of PTK2 kinase activity leading to either positive regulation of epithelial cell proliferation through the HRAS/RAF1 pathways, or negative regulation of apoptosis through the PDK1/AKT1 pathway (PubMed:20875407). May act in collecting-duct and biliary differentiation (By similarity). May participate in the regulation of the cholangiocytes proliferation and the CCN2 production in an CXCL8-dependent manner (By similarity). Interacts with CAMLG (PubMed:16243292). Interacts with PKD2 (PubMed:18235088). Interacts (via CST) with ARF4; this interaction allows an efficient PKHD1 trafficking to the cilium (PubMed:24586199). Interacts (via CST) with RAB8A; this interaction controls trafficking through the endomembrane systeme and to the cilium (PubMed:20048263). Interacts (via CST) with TULP3; this interaction allows PKHD1 trafficking to the cilium (PubMed:28154160). E9PZ36; P49069: CAMLG; Xeno; NbExp=4; IntAct=EBI-11693075, EBI-1748958; Cell membrane ; Single-pass membrane protein Cytoplasm Apical cell membrane Cytoplasm, cytoskeleton, cilium basal body Cell projection, cilium toplasm, cytoskeleton, spindle Chromosome, centromere Nucleus Secreted, extracellular exosome creted doplasmic reticulum Golgi apparatus Note=The intra-cellular C-terminal fragment (ICD) translocates to the nucleus and is not detected in primary cilia (PubMed:16956880, PubMed:28729032). The extracellular domain (PECD) traffics beyond the mid-Golgi and localizes on exosome like vesicles (ELVs) attached to the primary cilium (PubMed:22021705, PubMed:28729032). In the urine, the extracellular domain (PECD) exists as an highly abundant secreted form and a less abundant PECD form that is either tethered to or shed with the C-terminal fragment (PTM) in ELVs (PubMed:28729032). The majority of full length PKHD1 protein resides at the endoplasmic reticulum and cannot pass beyond the mid- Golgi apparatus and is not detected in primary cilia (PubMed:28729032). Expressed in bile ducts and distal nephron segments but is absent from the proximal tubule (PubMed:18202188). Expressed in pancreas and kidney but also in the liver (PubMed:28729032). Expressed primarily in the distal tubule and thick ascending limb of the loop of Henle, and at low-level in the proximal tubule before renal development is complete at P0 (PubMed:28729032). Palmitoylated (PubMed:20048263). Palmitoylation facilitates the trafficking to the cilia and membrane targeting (PubMed:20048263). N-glycosylated. Several proteolytic cleavages occur within the extracellular domain, whereas at least one cleavage occurs within the cytoplasmic domain (PubMed:16956880). Cleaved by a probable proprotein convertase which produces an extracellular domain (polyductin extracellular domain, (PECD)) and a C-terminal fragment (polyductin transmembrane fragment (PTM)) which are tethered together by disulfide bonds (PubMed:17470460, PubMed:28729032). This extracellular domain (PECD) is then shed from the primary cilium by activation of a member of the ADAM metalloproteinase disintegrins family, resulting in concomitant release of an intra-cellular C-terminal fragment (ICD) via a gamma-secretase- dependent process (PubMed:17470460, PubMed:28729032). The proteolytic cleavage of the C-terminal intracellular fragment (ICD) is controlled by cytosolic calcium concentration and activation of PKC (PubMed:16956880). A mouse model, for human autosomal recessive polycystic kidney disease (ARPKD), where homozygous knockout mice for the Pkhd1 gene are born at a frequency lower than the expected Mendelian ratio (PubMed:18235088). Homozygous mice may lead to embryonic lethality (PubMed:18235088). Mice that escape embryonic lethality and survive into adulthood exhibit mild to severe tubular dilation or cyst formation in the kidney and liver accompanied by fibrosis and necrosis (PubMed:18235088). Homozygous mice for the Pkhd1 gene develop cysts and fibrosis in the liver at 1 month of age, and females develop proximal tubule (PT) dilation at 6 months of age whereas male mice never develop PT dilation (PubMed:22021705). Both male and female homozygous mice develop liver cysts and fibrosis at 3 months of age and this worsens with age until the liver is completely replaced by cysts at 12 mo of age (PubMed:22021705). A new mouse model, for ARPKD, where homozygous knockout mice for the Pkhd1 gene develop biliary dysgenesis accompanied by periportal fibrosis. Despite the progressive liver disease, these mice are viable at 12 months of age with no apparent decline in synthetic liver function. These mice also develop extrahepatic phenotypes involving the pancreas, extrahepatic bile ducts, and spleen, which occur in a more variable manner (PubMed:18202188). An other model, for ARPKD, where homozygous knockout mice for the Pkhd1 gene develop progressive renal cystic disease involving the proximal tubules, collecting ducts, and glomeruli. In the liver, mice show dilatation of the bile ducts and periportal fibrosis. Dilatation of pancreatic exocrine ducts is uniformly seen, with pancreatic cysts arising less frequently (PubMed:18286309). kidney development protein binding cytoplasm centrosome cilium cellular calcium ion homeostasis positive regulation of cell proliferation regulation of centrosome duplication membrane integral component of membrane apical plasma membrane regulation of TOR signaling negative regulation of NF-kappaB transcription factor activity ciliary basal body negative regulation of apoptotic process perinuclear region of cytoplasm negative regulation of protein kinase B signaling cilium assembly regulation of ERK1 and ERK2 cascade mitotic spindle uc007akv.1 uc007akv.2 uc007akv.3 
ENSMUST00000088452.11 Slc38a1 ENSMUST00000088452.11 solute carrier family 38, member 1, transcript variant 3 (from RefSeq NM_001166458.1) ENSMUST00000088452.1 ENSMUST00000088452.10 ENSMUST00000088452.2 ENSMUST00000088452.3 ENSMUST00000088452.4 ENSMUST00000088452.5 ENSMUST00000088452.6 ENSMUST00000088452.7 ENSMUST00000088452.8 ENSMUST00000088452.9 NM_001166458 Nat2 Q3TNM1 Q3TQ53 Q6NXZ2 Q8BHI3 Q8BXE2 Q8K2P7 Q99PR1 S38A1_MOUSE Slc38a1 Snat1 uc007xkj.1 uc007xkj.2 uc007xkj.3 Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:11325958, PubMed:17179157, PubMed:32668809, PubMed:27655909). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:11325958). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (PubMed:31050701, PubMed:32668809). May also contributes to amino acid transport in placental trophoblast (By similarity). Regulates synaptic plasticity (PubMed:31050701). Reaction=L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out); Xref=Rhea:RHEA:68236, ChEBI:CHEBI:29101, ChEBI:CHEBI:58359; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68237; Evidence=; Reaction=L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out); Xref=Rhea:RHEA:29283, ChEBI:CHEBI:29101, ChEBI:CHEBI:57972; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29285; Evidence=; Reaction=L-histidine(in) + Na(+)(in) = L-histidine(out) + Na(+)(out); Xref=Rhea:RHEA:71583, ChEBI:CHEBI:29101, ChEBI:CHEBI:57595; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71585; Evidence=; Reaction=L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out); Xref=Rhea:RHEA:71383, ChEBI:CHEBI:29101, ChEBI:CHEBI:58048; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71385; Evidence=; Reaction=L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out); Xref=Rhea:RHEA:29575, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29577; Evidence=; Reaction=L-cysteine(in) + Na(+)(in) = L-cysteine(out) + Na(+)(out); Xref=Rhea:RHEA:68232, ChEBI:CHEBI:29101, ChEBI:CHEBI:35235; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68234; Evidence=; Reaction=L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out); Xref=Rhea:RHEA:68240, ChEBI:CHEBI:29101, ChEBI:CHEBI:57844; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68242; Evidence=; Reaction=glycine(in) + Na(+)(in) = glycine(out) + Na(+)(out); Xref=Rhea:RHEA:68228, ChEBI:CHEBI:29101, ChEBI:CHEBI:57305; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68230; Evidence=; Reaction=L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out); Xref=Rhea:RHEA:69999, ChEBI:CHEBI:29101, ChEBI:CHEBI:57926; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70001; Evidence=; Reaction=L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out); Xref=Rhea:RHEA:28967, ChEBI:CHEBI:29101, ChEBI:CHEBI:60039; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28969; Evidence=; Inhibited by alpha-(methylamino)isobutyric acid (MeAIB). Inhibited by lithium, potassium, choline ions, N- methylglucamine. The pH dependence has an allosteric effect on the transport. Kinetic parameters: KM=2400 uM for L-glutamine (at pH 7.0) ; KM=890 uM for L-glutamine (at pH 7.5) ; KM=540 uM for L-glutamine (at pH 8.0) ; Note=Decrease in pH from 8.0 to 7.0 results in decreased affinity for L-glutamine. ; Cell membrane ; Multi-pass membrane protein Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K2P7-1; Sequence=Displayed; Name=2; IsoId=Q8K2P7-2; Sequence=VSP_029307, VSP_029308; Name=3; IsoId=Q8K2P7-3; Sequence=VSP_029305, VSP_029306; Specifically expressed in brain and retina (at protein level). Also detected in spleen, small intestine and lung. Up-regulated by BDNF. N-glycosylation plays an important role in the L-glutamine transport. Belongs to the amino acid/polyamine transporter 2 family. amino acid transmembrane transport plasma membrane integral component of plasma membrane ion transport sodium ion transport amino acid transport glutamine transport female pregnancy amino acid transmembrane transporter activity L-glutamine transmembrane transporter activity symporter activity membrane integral component of membrane axon uc007xkj.1 uc007xkj.2 uc007xkj.3 
ENSMUST00000088455.6 Clec4b2 ENSMUST00000088455.6 C-type lectin domain family 4, member b2 (from RefSeq NM_001004159.2) Aplra1 Clec4b2 ENSMUST00000088455.1 ENSMUST00000088455.2 ENSMUST00000088455.3 ENSMUST00000088455.4 ENSMUST00000088455.5 NM_001004159 Q67DU8 Q67DU8_MOUSE uc009dqd.1 uc009dqd.2 uc009dqd.3 uc009dqd.4 positive regulation of antigen processing and presentation molecular_function external side of plasma membrane membrane integral component of membrane carbohydrate binding uc009dqd.1 uc009dqd.2 uc009dqd.3 uc009dqd.4 
ENSMUST00000088459.9 Pwwp4a ENSMUST00000088459.9 PWWP domain containing 4A (from RefSeq NM_001025383.2) DXBay18 ENSMUST00000088459.1 ENSMUST00000088459.2 ENSMUST00000088459.3 ENSMUST00000088459.4 ENSMUST00000088459.5 ENSMUST00000088459.6 ENSMUST00000088459.7 ENSMUST00000088459.8 Gm14685 NM_001025383 OTTMUSG00000017677 Pwwp4a Pwwp4b Q52KH6 Q52KH6_MOUSE uc009tlf.1 uc009tlf.2 uc009tlf.3 Belongs to the PWWP3A family. molecular_function cellular_component biological_process uc009tlf.1 uc009tlf.2 uc009tlf.3 
ENSMUST00000088476.5 Pi15 ENSMUST00000088476.5 peptidase inhibitor 15 (from RefSeq NM_053191.5) ENSMUST00000088476.1 ENSMUST00000088476.2 ENSMUST00000088476.3 ENSMUST00000088476.4 NM_053191 PI15_MOUSE Q3TN14 Q8BS03 Q99MM7 uc007ake.1 uc007ake.2 uc007ake.3 uc007ake.4 Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (By similarity). Secreted Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and thyroid gland. N-glycosylated. Belongs to the CRISP family. Sequence=BAC30762.1; Type=Erroneous initiation; Evidence=; extracellular region extracellular space multicellular organism development negative regulation of peptidase activity peptidase inhibitor activity uc007ake.1 uc007ake.2 uc007ake.3 uc007ake.4 
ENSMUST00000088481.5 Magea10 ENSMUST00000088481.5 MAGE family member A10 (from RefSeq NM_001085506.1) A2AMW4 A2AMW4_MOUSE ENSMUST00000088481.1 ENSMUST00000088481.2 ENSMUST00000088481.3 ENSMUST00000088481.4 Magea10 NM_001085506 uc009tko.1 uc009tko.2 molecular_function nucleoplasm cytosol biological_process uc009tko.1 uc009tko.2 
ENSMUST00000088483.10 Gpc6 ENSMUST00000088483.10 glypican 6, transcript variant 2 (from RefSeq NM_011821.3) ENSMUST00000088483.1 ENSMUST00000088483.2 ENSMUST00000088483.3 ENSMUST00000088483.4 ENSMUST00000088483.5 ENSMUST00000088483.6 ENSMUST00000088483.7 ENSMUST00000088483.8 ENSMUST00000088483.9 GPC6_MOUSE NM_011821 Q9R087 uc288wlh.1 uc288wlh.2 Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling (By similarity). Cell membrane ; Lipid-anchor, GPI- anchor ; Extracellular side [Secreted glypican-6]: Secreted, extracellular space In the cartilage growth-plate, gradient of expression with highest levels from the proliferative and pre- hypertrophic zones to lowest, if any, in the hypertrophic zones (at protein level). Detected from 7 to 17 dpc. Overall expression clearly diminishes after 13 dpc. Mostly expressed in mesoderm-derived tissues, but also present in some neurectoderm-derived sites. High expression limited to mesenchymal tissues. In 11.5 and 13.5 dpc lungs, mostly restricted to the peribronchial mesenchymal cells. In the aorta and other major blood vessels, found in the subendothelial smooth muscle cell layers. Also expressed in the outflow tract of the heart ventricle, but not in other parts of the heart. At 13.5 dpc, in the developing kidney, detected in the metanephric cap mesenchyme of the cortical region, in the condensing mesenchyme surrounding the ureteric branches. Not detected in the adrenal glands. At 11.5 and 13.5 dpc, expressed weakly in the liver septae, but not in the parenchyme. Very strong expression in both the stomach and intestine, in the submucosal layers, in the condensing splanchnic mesenchyme. At 13.5 dpc, expressed in the mesenchymal cells of pancreas, gonad, mesonephric tissue and genital eminence. At 13.5 dpc, expressed in the thymus. At 11.5 dpc, strong expression in the mesenchyme of the mandibular process, with highest expression in the mesenchymal cell layer just below the oral epithelium. Not detected in the overlying epithelium. At 13.5 dpc, highly expressed in the dental mesenchyme surrounding the epithelial bud and near the top of the lip furrow, as well as in the tongue. At 13.5 dpc, expressed in the cartilage primordia of the ear and snout. Highly expressed in intervertebral disks, but not detected in the notochord and vertebrae, both at 11.5 and 13.5 dpc. Highly expressed in mesenchymal condensations of both the forelimb and hindlimb. Overall low expression in the nervous system. At 11.5 dpc, low expression in the neuroepithelium of the hindbrain, the telencephalic vesicle and neuro-epithelial cells lining the mesencephalic vesicle. At 13.5 dpc, detected in the roof of the neopallial cortex, which gives rise to the future cerebral cortex. Weak expression also observed in the medulla oblongata, the choroid plexus, and the ventral mantle layer of the spinal cord. Stronger expression in the ganglia of the glossopharyngeal nerve. At 11.5 and 13.5 dpc, expressed in the mesenchyme surrounding the olfactory epithelium, but not in the epithelium itself. Similarly expressed in the mesenchymal tissues lining the dorsal root ganglia (perineurium), but not in the ganglia. Expression also observed in a few epithelial cells (ectodermal origin), including, at 11.5 dpc, the ventromedial wall of the otic vesicle and, at 13.5 dpc, the cochlea of the inner ear. In the eye, expressed not only in the neural retina but also the cells that compose the wall of the lens vesicle. Belongs to the glypican family. extracellular region extracellular space Golgi lumen plasma membrane integral component of plasma membrane regulation of signal transduction cell surface membrane cell migration anchored component of membrane synapse anchored component of plasma membrane glutamatergic synapse synaptic membrane adhesion regulation of protein localization to membrane regulation of presynapse assembly uc288wlh.1 uc288wlh.2 
ENSMUST00000088494.3 Blcap ENSMUST00000088494.3 bladder cancer associated protein, transcript variant 2 (from RefSeq NM_016916.3) A2AFZ4 BLCAP_MOUSE Bc10 ENSMUST00000088494.1 ENSMUST00000088494.2 NM_016916 O60629 P62951 Q3TD76 Q5XJG3 Q9D3B5 uc008npd.1 uc008npd.2 May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. Membrane ; Multi-pass membrane protein Belongs to the BLCAP family. molecular_function apoptotic process cell cycle biological_process membrane integral component of membrane apoptotic nuclear changes uc008npd.1 uc008npd.2 
ENSMUST00000088506.12 Dnase1l2 ENSMUST00000088506.12 deoxyribonuclease 1-like 2 (from RefSeq NM_025718.4) DNSL2_MOUSE ENSMUST00000088506.1 ENSMUST00000088506.10 ENSMUST00000088506.11 ENSMUST00000088506.2 ENSMUST00000088506.3 ENSMUST00000088506.4 ENSMUST00000088506.5 ENSMUST00000088506.6 ENSMUST00000088506.7 ENSMUST00000088506.8 ENSMUST00000088506.9 NM_025718 Q3KQI2 Q9D1G0 Q9D645 uc008avx.1 uc008avx.2 uc008avx.3 Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells (By similarity). Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Cytoplasm Secreted Belongs to the DNase I family. DNA catabolic process, endonucleolytic hair follicle development corneocyte development DNA binding nuclease activity endonuclease activity deoxyribonuclease I activity deoxyribonuclease activity extracellular region nucleus cytoplasm DNA catabolic process hydrolase activity metal ion binding uc008avx.1 uc008avx.2 uc008avx.3 
ENSMUST00000088512.13 Rnps1 ENSMUST00000088512.13 RNA binding protein with serine rich domain 1, transcript variant 2 (from RefSeq NM_001080127.1) ENSMUST00000088512.1 ENSMUST00000088512.10 ENSMUST00000088512.11 ENSMUST00000088512.12 ENSMUST00000088512.2 ENSMUST00000088512.3 ENSMUST00000088512.4 ENSMUST00000088512.5 ENSMUST00000088512.6 ENSMUST00000088512.7 ENSMUST00000088512.8 ENSMUST00000088512.9 NM_001080127 Q3TMJ1 Q922H8 Q99M28 RNPS1_MOUSE uc008avt.1 uc008avt.2 uc008avt.3 uc008avt.4 Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate- dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20- 25 nt upstream of exon-exon junctions (By similarity). Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10 (By similarity). Nucleus Nucleus speckle Cytoplasm Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99M28-1; Sequence=Displayed; Name=2; IsoId=Q99M28-2; Sequence=VSP_016244; The RRM domain is required for the formation of the ASAP complex. Phosphorylated on one or more of the four Ser/Thr residues (Ser- 43, Thr-49, Ser-52 or Ser-53). Ser-53 phosphorylation site is important for splicing and translation stimulation activity in vitro (By similarity). Belongs to the splicing factor SR family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA 3'-UTR binding nucleus nucleoplasm cytoplasm mRNA processing RNA splicing nuclear speck positive regulation of apoptotic process negative regulation of mRNA splicing, via spliceosome ASAP complex uc008avt.1 uc008avt.2 uc008avt.3 uc008avt.4 
ENSMUST00000088516.10 Magi2 ENSMUST00000088516.10 membrane associated guanylate kinase, WW and PDZ domain containing 2, transcript variant 1 (from RefSeq NM_001170746.1) Acvrinp1 Aip1 Arip1 ENSMUST00000088516.1 ENSMUST00000088516.2 ENSMUST00000088516.3 ENSMUST00000088516.4 ENSMUST00000088516.5 ENSMUST00000088516.6 ENSMUST00000088516.7 ENSMUST00000088516.8 ENSMUST00000088516.9 MAGI2_MOUSE NM_001170746 Q3UH81 Q6GT88 Q8BYT1 Q8CA85 Q9WVQ1 uc012dsm.1 uc012dsm.2 uc012dsm.3 Seems to act as a scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins (By similarity). Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth (By similarity). May play a role in regulating activin-mediated signaling in neuronal cells (PubMed:10681527). Enhances the ability of PTEN to suppress AKT1 activation (By similarity). Plays a role in receptor- mediated clathrin-dependent endocytosis which is required for ciliogenesis (PubMed:24608321). Interacts (via its WW domains) with DRPLA (By similarity). Interacts (via its second PDZ domain) with PTEN (via unphosphorylated C-terminus); this interaction diminishes the degradation rate of PTEN (By similarity). Interacts (via guanylate kinase domain) with DLGAP1 (By similarity). Interacts (via the PDZ domains) with GRIN2A, GRID2 and NLGN1 (By similarity). Interacts with CTNND2, CTNNB1 and MAGUIN-1 (By similarity). Interacts with ACVR2A, SMAD2 and SMAD3 (PubMed:10681527). Part of a complex consisting of MAGI2/ARIP1, ACVR2A, ACVR1B and SMAD3 (PubMed:10681527). May interact with HTR2A (PubMed:14988405). Interacts with RAPGEF2 (By similarity). Identified in a complex with ACTN4, CASK, IQGAP1, NPHS1, SPTAN1 and SPTBN1 (By similarity). Interacts with DDN (By similarity). Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a NGF-dependent manner (By similarity). Interacts with RAPGEF2; the interaction occurs before or after nerve growth factor (NGF) stimulation (By similarity). Interacts (via PDZ domain) with KIDINS220 (via C-terminal domain) (By similarity). Interacts with IGSF9 and HTR4 (PubMed:15466885, PubMed:15340156). Interacts with DLL1 (PubMed:15509766). Found in a complex with IGSF9B and NLGN2; the interaction with IGSF9B is mediated via the PDZ 5 and PDZ 6 domains, while the interaction with NLGN2 is mediated via the WW1, WW2 and PDZ2 domains (PubMed:23751499). Interacts (via PDZ 6 domain) with USH1G (via SAM domain); the interaction is triggered by phosphorylation of USH1G by CK2 and negatively regulates MAGI2-mediated endocytosis (PubMed:24608321). Q9WVQ1; Q61483: Dll1; NbExp=3; IntAct=EBI-297151, EBI-297125; Cytoplasm Late endosome Synapse, synaptosome Cell membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Photoreceptor inner segment Cell projection, cilium, photoreceptor outer segment Note=Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=long; IsoId=Q9WVQ1-1; Sequence=Displayed; Name=2; Synonyms=short; IsoId=Q9WVQ1-2; Sequence=VSP_008436; Name=3; IsoId=Q9WVQ1-3; Sequence=VSP_018580, VSP_008437; Name=4; IsoId=Q9WVQ1-4; Sequence=VSP_008436, VSP_018581; Expressed throughout the retina except in the nuclear layers and the photoreceptor outer segments (at protein level) (PubMed:24608321). Highest retinal expression is observed in the outer plexiform layer, the outer limiting membrane and the inner segment of photoreceptor cells (at protein level) (PubMed:24608321). Expressed in brain. [Isoform 2]: Major. [Isoform 3]: May be due to an intron retention. Belongs to the MAGUK family. positive regulation of receptor internalization protein binding nucleus cytoplasm endosome late endosome plasma membrane cell-cell junction bicellular tight junction signal transduction nervous system development negative regulation of cell proliferation positive regulation of signal transduction positive regulation of neuron projection development postsynaptic density membrane kinesin binding phosphatase binding cell junction receptor signaling complex scaffold activity negative regulation of cell migration dendrite beta-1 adrenergic receptor binding positive regulation of phosphoprotein phosphatase activity negative regulation of activin receptor signaling pathway macromolecular complex slit diaphragm nerve growth factor signaling pathway neuron projection receptor clustering macromolecular complex binding synapse SMAD binding perinuclear region of cytoplasm protein heterooligomerization negative regulation of protein kinase B signaling binding, bridging SMAD protein signal transduction activin receptor binding type II activin receptor binding mitotic cell cycle arrest glomerular visceral epithelial cell development neuroligin clustering involved in postsynaptic membrane assembly structural constituent of postsynaptic specialization maintenance of postsynaptic specialization structure extrinsic component of postsynaptic membrane structural constituent of postsynaptic density glutamatergic synapse GABA-ergic synapse maintenance of postsynaptic density structure cellular response to nerve growth factor stimulus positive regulation of synaptic vesicle clustering uc012dsm.1 uc012dsm.2 uc012dsm.3 
ENSMUST00000088538.6 Kcnip3 ENSMUST00000088538.6 Kv channel interacting protein 3, calsenilin, transcript variant 2 (from RefSeq NM_001111331.1) ENSMUST00000088538.1 ENSMUST00000088538.2 ENSMUST00000088538.3 ENSMUST00000088538.4 ENSMUST00000088538.5 Kcnip3 NM_001111331 Q3YAA9 Q3YAA9_MOUSE uc008mfl.1 uc008mfl.2 uc008mfl.3 calcium ion binding uc008mfl.1 uc008mfl.2 uc008mfl.3 
ENSMUST00000088542.4 Xkr9 ENSMUST00000088542.4 X-linked Kx blood group related 9 (from RefSeq NM_001011873.2) B2RWB3 ENSMUST00000088542.1 ENSMUST00000088542.2 ENSMUST00000088542.3 Gm1620 NM_001011873 Q5GH62 XKR9_MOUSE Xkr9 Xrg9 uc007aiv.1 uc007aiv.2 [XK-related protein 9, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:25231987). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:25231987). [XK-related protein 9, processed form]: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence=; Activated upon caspase cleavage to generate the XK-related protein 9, processed form (PubMed:25231987). Does not act prior the onset of apoptosis (PubMed:25231987). Cell membrane ; Multi-pass membrane protein Highly expressed in the small intestines; weakly expressed in the pancreas, liver, stomach, and large intestines. [XK-related protein 9]: Undergoes proteolytic processing by caspase-3 (CASP3), caspase-6 (CASP6) and caspase-7 (CASP7) to generate the XK-related protein 9, processed form, leading to its activation. Belongs to the XK family. molecular_function plasma membrane membrane integral component of membrane engulfment of apoptotic cell phosphatidylserine exposure on apoptotic cell surface apoptotic process involved in development uc007aiv.1 uc007aiv.2 
ENSMUST00000088552.7 Myl9 ENSMUST00000088552.7 myosin, light polypeptide 9, regulatory, transcript variant 1 (from RefSeq NM_172118.2) ENSMUST00000088552.1 ENSMUST00000088552.2 ENSMUST00000088552.3 ENSMUST00000088552.4 ENSMUST00000088552.5 ENSMUST00000088552.6 MYL9_MOUSE Myrl2 NM_172118 Q3TW15 Q80X77 Q9CQ19 uc008nnw.1 uc008nnw.2 uc008nnw.3 uc008nnw.4 Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, regulates PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (PubMed:29799007). Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin heavy chain MYO19. Cytoplasm, cytoskeleton Cytoplasm, cell cortex Note=Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts. Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity). Phosphorylation is required for myotube formation (PubMed:29799007). This chain binds calcium. stress fiber calcium ion binding myosin complex myosin II complex Z disc myosin heavy chain binding metal ion binding uc008nnw.1 uc008nnw.2 uc008nnw.3 uc008nnw.4 
ENSMUST00000088561.10 Pex26 ENSMUST00000088561.10 peroxisomal biogenesis factor 26, transcript variant 1 (from RefSeq NM_028730.6) ENSMUST00000088561.1 ENSMUST00000088561.2 ENSMUST00000088561.3 ENSMUST00000088561.4 ENSMUST00000088561.5 ENSMUST00000088561.6 ENSMUST00000088561.7 ENSMUST00000088561.8 ENSMUST00000088561.9 NM_028730 PEX26_MOUSE Pex26 Q3UGH5 Q8BGI5 Q9D661 uc009dod.1 uc009dod.2 uc009dod.3 This gene is a member of the peroxin-26 family. The encoded protein is probably required for protein import into peroxisomes. It may anchor Pex1 and Pex6 to peroxisome membranes. Defects in a similar gene in human are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2015]. Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes. PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane. Interacts (via its cytoplasmic domain) with PEX6; interaction is direct and is ATP-dependent. Interacts with PEX1; interaction is indirect and is mediated via interaction with PEX6. Peroxisome membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGI5-1; Sequence=Displayed; Name=2; IsoId=Q8BGI5-2; Sequence=VSP_010444; Belongs to the peroxin-26 family. peroxisome peroxisomal membrane integral component of peroxisomal membrane protein C-terminus binding protein transport membrane integral component of membrane protein import into peroxisome matrix macromolecular complex binding protein import into peroxisome membrane ATPase binding uc009dod.1 uc009dod.2 uc009dod.3 
ENSMUST00000088610.11 Romo1 ENSMUST00000088610.11 reactive oxygen species modulator 1, transcript variant 2 (from RefSeq NM_001164217.2) A2BHV9 ENSMUST00000088610.1 ENSMUST00000088610.10 ENSMUST00000088610.2 ENSMUST00000088610.3 ENSMUST00000088610.4 ENSMUST00000088610.5 ENSMUST00000088610.6 ENSMUST00000088610.7 ENSMUST00000088610.8 ENSMUST00000088610.9 NM_001164217 P60603 Q9CQ98 Q9H1N2 ROMO1_MOUSE uc008nmm.1 uc008nmm.2 uc008nmm.3 uc008nmm.4 Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity). Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation (By similarity). Mitochondrion inner membrane ; Single-pass membrane protein Detected in brain, liver and kidney. Belongs to the MGR2 family. replicative cell aging molecular_function mitochondrion mitochondrial inner membrane mitochondrial inner membrane presequence translocase complex positive regulation of cell proliferation membrane integral component of membrane protein import into mitochondrial matrix killing of cells of other organism cellular response to reactive oxygen species defense response to bacterium protein import into mitochondrial inner membrane defense response to Gram-negative bacterium defense response to Gram-positive bacterium cytolysis in other organism positive regulation of reactive oxygen species metabolic process uc008nmm.1 uc008nmm.2 uc008nmm.3 uc008nmm.4 
ENSMUST00000088614.13 Kif21a ENSMUST00000088614.13 kinesin family member 21A, transcript variant 6 (from RefSeq NM_001411306.1) ENSMUST00000088614.1 ENSMUST00000088614.10 ENSMUST00000088614.11 ENSMUST00000088614.12 ENSMUST00000088614.2 ENSMUST00000088614.3 ENSMUST00000088614.4 ENSMUST00000088614.5 ENSMUST00000088614.6 ENSMUST00000088614.7 ENSMUST00000088614.8 ENSMUST00000088614.9 KI21A_MOUSE Kiaa1708 NM_001411306 Q6P5H1 Q6ZPJ8 Q8BWZ9 Q8BXF1 Q9QXL2 uc007xhs.1 uc007xhs.2 uc007xhs.3 uc007xhs.4 uc007xhs.5 Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity. Interacts (via residues 1148-1169) with KANK1 (via ankyrin repeats 1-5) and KANK2 (via ankyrin repeats 1-5). Cytoplasm, cytoskeleton Cell projection, dendrite Cell projection, axon Note=In neurons, localized to axons and dendrites. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9QXL2-1; Sequence=Displayed; Name=2; IsoId=Q9QXL2-2; Sequence=VSP_010873, VSP_010874, VSP_010875; Name=3; IsoId=Q9QXL2-3; Sequence=VSP_010873, VSP_010876; Name=4; IsoId=Q9QXL2-4; Sequence=VSP_010877; Widely expressed, with highest expression in brain. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding microtubule motor activity ATP binding cytoplasm cytosol cytoskeleton kinesin complex microtubule plasma membrane microtubule-based movement microtubule binding ATPase activity axon dendrite cell projection uc007xhs.1 uc007xhs.2 uc007xhs.3 uc007xhs.4 uc007xhs.5 
ENSMUST00000088615.11 Arfgef1 ENSMUST00000088615.11 ADP ribosylation factor guanine nucleotide exchange factor 1 (from RefSeq NM_001102430.1) BIG1_MOUSE ENSMUST00000088615.1 ENSMUST00000088615.10 ENSMUST00000088615.2 ENSMUST00000088615.3 ENSMUST00000088615.4 ENSMUST00000088615.5 ENSMUST00000088615.6 ENSMUST00000088615.7 ENSMUST00000088615.8 ENSMUST00000088615.9 G3X9K3 NM_001102430 Q8BKL2 uc007ahn.1 uc007ahn.2 uc007ahn.3 Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined (By similarity). Inhibited by brefeldin A. Homodimer. Interacts with ARFGEF2/BIG2; both proteins are probably part of the same or very similar macromolecular complexes. Interacts with FKBP2. Interacts with MYO9B. Interacts with PRKAR1A and PRKAR2A. Interacts with PPP1CC. Interacts with NCL, FBL, NUP62 and U3 small nucleolar RNA. Interacts with DPY30. Interacts with PDE3A. Interacts with KANK1. Interacts with TBC1D22A and TBC1D22B. Cytoplasm Cytoplasm, perinuclear region Golgi apparatus Golgi apparatus, trans-Golgi network Nucleus Nucleus, nucleolus Nucleus matrix Membrane Note=Translocates from cytoplasm to membranes and nucleus upon cAMP treatment. Phosphorylated. In vitro phosphorylated by PKA reducing its GEF activity and dephosphorylated by phosphatase PP1 (By similarity). Golgi membrane guanyl-nucleotide exchange factor activity ARF guanyl-nucleotide exchange factor activity nucleus nucleoplasm nucleolus cytoplasm Golgi apparatus trans-Golgi network cytosol Golgi organization endomembrane system organization protein transport membrane nuclear matrix myosin binding small nuclear ribonucleoprotein complex negative regulation of actin filament polymerization neuron projection development regulation of ARF protein signal transduction protein kinase A regulatory subunit binding negative regulation of GTPase activity perinuclear region of cytoplasm positive regulation of protein kinase B signaling positive regulation of protein glycosylation in Golgi positive regulation of wound healing regulation of establishment of cell polarity uc007ahn.1 uc007ahn.2 uc007ahn.3 
ENSMUST00000088616.12 Speer1h ENSMUST00000088616.12 Speer1h (from geneSymbol) BC110565 ENSMUST00000088616.1 ENSMUST00000088616.10 ENSMUST00000088616.11 ENSMUST00000088616.2 ENSMUST00000088616.3 ENSMUST00000088616.4 ENSMUST00000088616.5 ENSMUST00000088616.6 ENSMUST00000088616.7 ENSMUST00000088616.8 ENSMUST00000088616.9 F6YJZ8 F6YJZ8_MOUSE Gm6460 uc290tdw.1 uc290tdw.2 molecular_function cellular_component biological_process uc290tdw.1 uc290tdw.2 
ENSMUST00000088627.11 Zic3 ENSMUST00000088627.11 zinc finger protein of the cerebellum 3 (from RefSeq NM_009575.2) A2AWK3 ENSMUST00000088627.1 ENSMUST00000088627.10 ENSMUST00000088627.2 ENSMUST00000088627.3 ENSMUST00000088627.4 ENSMUST00000088627.5 ENSMUST00000088627.6 ENSMUST00000088627.7 ENSMUST00000088627.8 ENSMUST00000088627.9 NM_009575 Q3UYV1 Q62521 Q8BSB3 ZIC3_MOUSE uc009tho.1 uc009tho.2 uc009tho.3 Acts as a transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC- 3'. Interacts with KPNA1 and KPNA6. Interacts (via C2H2-type domains 3, 4 and 5) with GLI3; the interaction enhances its transcriptional activity (By similarity). Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5); the interaction reduces its transcriptional activity. Nucleus Cytoplasm Note=Translocation to the nucleus requires KPNA1 or KPNA6 (By similarity). Localizes in the cytoplasm in presence of MDFIC overexpression. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Zic3-A; IsoId=Q62521-1; Sequence=Displayed; Name=2; Synonyms=Zic3-B; IsoId=Q62521-2; Sequence=VSP_044011; CNS. A high level expression is seen in the cerebellum. Expressed in the CNS, tailbud and somites. The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation. Some mice exhibit embryonic and postnatal lethality. Viable mice show heart disease, disturbances of laterality, neural tube defects and vertebral and rib defects. Belongs to the GLI C2H2-type zinc-finger protein family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding heart looping nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm multicellular organism development determination of left/right symmetry pattern specification process nervous system development central nervous system development anterior/posterior pattern specification cell differentiation lung development determination of pancreatic left/right asymmetry determination of left/right asymmetry in nervous system sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding determination of digestive tract left/right asymmetry determination of liver left/right asymmetry uc009tho.1 uc009tho.2 uc009tho.3 
ENSMUST00000088652.6 Htatsf1 ENSMUST00000088652.6 HIV TAT specific factor 1, transcript variant 2 (from RefSeq NM_029371.1) B1AVC7 ENSMUST00000088652.1 ENSMUST00000088652.2 ENSMUST00000088652.3 ENSMUST00000088652.4 ENSMUST00000088652.5 HTSF1_MOUSE NM_029371 Q1WWK0 Q8BGC0 Q9CT41 Q9DAU3 uc009tgw.1 uc009tgw.2 uc009tgw.3 uc009tgw.4 uc009tgw.5 Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre- mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop. HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint- interacting stem loop and allowing to probe intron branch site sequences. Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation. Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites. Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly- ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination. Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Within the 17S U2 SnRNP complex, interacts (via UHM region) directly with SF3B1. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with GTF2F2/RAP30 and POLR2A. Interacts with TCERG1/CA150. Interacts with (poly-ADP-ribosylated) RPA1; promoting HTATSF1 recruitment to DNA damage sites. Interacts (when phosphorylated) with TOPBP1; promoting recruitment of TOPBP1 to DNA damage sites during S-phase. Nucleus Chromosome Note=Recruited to DNA damage sites during S-phase following interaction with poly-ADP-ribosylated RPA1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGC0-1; Sequence=Displayed; Name=2; IsoId=Q8BGC0-2; Sequence=VSP_020332, VSP_020333; The RRM domains mediate interaction with U snRNPs. The RRM domains specifically bind poly-ADP-ribosylated RPA1. Phosphorylation at Ser-749 by CK2 during S-phase in response to DNA damage promotes interaction with TOPBP1 and double-strand break (DSB) repair via homologous recombination. Belongs to the HTATSF1 family. Sequence=AAI14589.1; Type=Erroneous initiation; Evidence=; Sequence=AAI14590.1; Type=Erroneous initiation; Evidence=; mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus nucleoplasm U2-type spliceosomal complex U2 snRNP uc009tgw.1 uc009tgw.2 uc009tgw.3 uc009tgw.4 uc009tgw.5 
ENSMUST00000088653.3 Ccdc87 ENSMUST00000088653.3 coiled-coil domain containing 87 (from RefSeq NM_207268.3) A6H5W2 CCD87_MOUSE ENSMUST00000088653.1 ENSMUST00000088653.2 NM_207268 Q8CDL9 uc008gbb.1 uc008gbb.2 Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility. Specifically expressed in testis (at protein level). Not detected in other tissues tested (at protein level). In the testis, localizes to pachytene spermatocytes and spermatids. Detected from postnatal day 14 onwards. Maintained at high levels through to adulthood. No gross phenotype. Males have significantly reduced fertility. Testis weight, testis histology and sperm counts are normal. Approximately 25% of sperm have morphological defects in the sperm head and sperm nucleus, while morphology of the sperm flagellum appears normal. Capacitation-induced sperm motility is initially slightly reduced but then recovers. Frequency of both spontaenous and P4-induced acrosome reactions are significantly reduced. In an in-vitro fertilization assay, spermatozoa are able to bind and penetrate the oocyte perivitelline space but fertilizing capacity is severely impaired. Belongs to the CCDC87 family. molecular_function cellular_component spermatogenesis single fertilization cell differentiation positive regulation of fertilization positive regulation of acrosome reaction uc008gbb.1 uc008gbb.2 
ENSMUST00000088666.4 Vxn ENSMUST00000088666.4 vexin (from RefSeq NM_178399.4) ENSMUST00000088666.1 ENSMUST00000088666.2 ENSMUST00000088666.3 NM_178399 Q8BG31 VEXIN_MOUSE Vxn uc007agp.1 uc007agp.2 uc007agp.3 Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis (PubMed:29518376). Cell membrane Nucleus Note=Nuclear localization is essential for its function in neurogenesis. Belongs to the vexin family. molecular_function nucleus plasma membrane nervous system development membrane neurogenesis neuron differentiation uc007agp.1 uc007agp.2 uc007agp.3 
ENSMUST00000088677.5 Htr1d ENSMUST00000088677.5 5-hydroxytryptamine (serotonin) receptor 1D, transcript variant 2 (from RefSeq NM_008309.5) 5HT1D_MOUSE ENSMUST00000088677.1 ENSMUST00000088677.2 ENSMUST00000088677.3 ENSMUST00000088677.4 Gpcr14 NM_008309 Q3ZB48 Q61224 Q61615 Q8BUW7 uc008vic.1 uc008vic.2 uc008vic.3 uc008vic.4 uc008vic.5 G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. Homodimer. Heterodimer with HTR1B (By similarity). Cell membrane; Multi-pass membrane protein. Detected in the motor column in spinal cord, and in several cranial motor nuclei, including nucleus ambiguous, oculomotoris, trochelaris and abducens. Detected in gamma motor neurons in the lumbar spinal cord. Detected in proprioceptive sensory neurons in dorsal root ganglia. No visible phenotype. Depending on the task, mutant mice show improved motor coordination, especially in avoiding hind limb slips when crossing a narrow beam and in climbing onto a horizontal hanging wire. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway chemical synaptic transmission response to toxic substance intestine smooth muscle contraction membrane integral component of membrane dendrite neurotransmitter receptor activity regulation of locomotion vasoconstriction regulation of behavior serotonin binding uc008vic.1 uc008vic.2 uc008vic.3 uc008vic.4 uc008vic.5 
ENSMUST00000088737.11 Grk2 ENSMUST00000088737.11 G protein-coupled receptor kinase 2, transcript variant 3 (from RefSeq NM_001425877.1) ARBK1_MOUSE Adrbk1 ENSMUST00000088737.1 ENSMUST00000088737.10 ENSMUST00000088737.2 ENSMUST00000088737.3 ENSMUST00000088737.4 ENSMUST00000088737.5 ENSMUST00000088737.6 ENSMUST00000088737.7 ENSMUST00000088737.8 ENSMUST00000088737.9 Grk2 NM_001425877 Q99LL8 Q99MK8 uc008fzv.1 uc008fzv.2 uc008fzv.3 uc008fzv.4 Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (By similarity). Key regulator of LPAR1 signaling (By similarity). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO)- dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927). Reaction=[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]- phosphate + ADP + H(+); Xref=Rhea:RHEA:19429, Rhea:RHEA-COMP:11222, Rhea:RHEA-COMP:11223, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19430; Evidence=; In contrast to other AGC family kinases, the catalytic activity is solely regulated by the binding of substrates and ligands, not by phosphorylation of the kinase domain. Interacts with the heterodimer formed by GNB1 and GNG2 (By similarity). Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5 (By similarity). Interacts with ARRB1 (By similarity). Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation (By similarity). ADRBK1 and RALA mutually inhibit each other's binding to LPAR1 (By similarity). Interacts with ADRB2 (By similarity). Cytoplasm Cell membrane Postsynapse Presynapse The PH domain binds anionic phospholipids and helps recruiting ADRBK1 from the cytoplasm to plasma membrane close to activated receptors. It mediates binding to G protein beta and gamma subunits, competing with G-alpha subunits and other G-betagamma effectors. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. nucleotide binding G-protein coupled receptor binding regulation of the force of heart contraction desensitization of G-protein coupled receptor protein signaling pathway negative regulation of the force of heart contraction by chemical signal protein kinase activity protein serine/threonine kinase activity G-protein coupled receptor kinase activity protein binding ATP binding nucleus cytoplasm mitochondrion cytosol plasma membrane caveola cilium protein phosphorylation response to oxidative stress signal transduction G-protein coupled receptor signaling pathway tachykinin receptor signaling pathway heart development positive regulation of muscle cell apoptotic process negative regulation of peptidyl-threonine phosphorylation response to organic cyclic compound membrane kinase activity phosphorylation basolateral plasma membrane apical plasma membrane transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation viral genome replication axon receptor internalization ubiquitin protein ligase binding Edg-2 lysophosphatidic acid receptor binding delta-type opioid receptor binding kappa-type opioid receptor binding negative regulation of peptidyl-serine phosphorylation positive regulation of catecholamine secretion follicle-stimulating hormone signaling pathway negative regulation of apoptotic process dendritic spine dendritic shaft membrane raft synapse positive regulation of interleukin-6 biosynthetic process negative regulation of G-protein coupled receptor protein signaling pathway positive regulation of vasoconstriction negative regulation of striated muscle contraction negative regulation of glucose import viral entry into host cell beta-adrenergic receptor kinase activity positive regulation of fibroblast proliferation oligodendrocyte differentiation maintenance of protein location in nucleus cardiac muscle contraction cellular response to glucose stimulus cellular response to epidermal growth factor stimulus scaffold protein binding negative regulation of cellular response to insulin stimulus positive regulation of sensory perception of pain positive regulation of vascular smooth muscle cell proliferation cellular response to chemokine negative regulation of cysteine-type endopeptidase activity positive regulation of excitatory postsynaptic potential uc008fzv.1 uc008fzv.2 uc008fzv.3 uc008fzv.4 
ENSMUST00000088740.5 Slxl1 ENSMUST00000088740.5 Slx-like 1 (from RefSeq NM_029181.1) ENSMUST00000088740.1 ENSMUST00000088740.2 ENSMUST00000088740.3 ENSMUST00000088740.4 NM_029181 Q9D515 Q9D515_MOUSE Slxl1 uc009tfx.1 uc009tfx.2 uc009tfx.3 uc009tfx.4 synaptonemal complex acrosomal vesicle protein binding cytoplasm spermatogenesis spermatid development single fertilization binding of sperm to zona pellucida sex determination regulation of gene expression spermatid differentiation meiotic cell cycle uc009tfx.1 uc009tfx.2 uc009tfx.3 uc009tfx.4 
ENSMUST00000088761.11 Adam22 ENSMUST00000088761.11 a disintegrin and metallopeptidase domain 22, transcript variant 5 (from RefSeq NM_001310440.2) ADA22_MOUSE ENSMUST00000088761.1 ENSMUST00000088761.10 ENSMUST00000088761.2 ENSMUST00000088761.3 ENSMUST00000088761.4 ENSMUST00000088761.5 ENSMUST00000088761.6 ENSMUST00000088761.7 ENSMUST00000088761.8 ENSMUST00000088761.9 NM_001310440 Q5TLI8 Q5TLI9 Q5TLJ0 Q5TLJ1 Q5TLJ2 Q5TLJ3 Q5TLJ4 Q5TLJ5 Q5TLJ6 Q5TLJ7 Q5TLJ8 Q5TLJ9 Q5TLK0 Q5TLK1 Q5TLK2 Q5TLK3 Q5TLK4 Q5TLK5 Q5TLK6 Q5TLK7 Q5TLK8 Q8BSF2 Q9R1V5 Q9R1V6 uc008wjk.1 uc008wjk.2 uc008wjk.3 uc008wjk.4 uc008wjk.5 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit severe ataxia, hypomyelination and premature death. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]. Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1. Interacts with LGI1 (PubMed:16990550, PubMed:18974846, PubMed:20089912). Can bind to LGI4 (PubMed:18974846). Interacts with KCNA2, DLG2 and DLG4 (PubMed:20089912). Interacts with ADAM11 (PubMed:26269648). Interacts (via C-terminus) with YWHAB/14-3-3 beta (By similarity). Interacts (via C-terminus) with YWHAZ/14-3-3 zeta (By similarity). Cell membrane ; Single-pass type I membrane protein Cell projection, axon Event=Alternative splicing; Named isoforms=21; Name=1; Synonyms=ADAM22-G01, 22g; IsoId=Q9R1V6-3; Sequence=Displayed; Name=2; Synonyms=ADAM22-G03, 22g(D27); IsoId=Q9R1V6-4; Sequence=VSP_018238; Name=3; Synonyms=ADAM22-G06, 22g(D26D27); IsoId=Q9R1V6-5; Sequence=VSP_018235; Name=4; Synonyms=ADAM22=G07, 22g(D26D27)+29.3; IsoId=Q9R1V6-6; Sequence=VSP_018235, VSP_018245; Name=5; Synonyms=ADAM22-G08, 22g(D27)+29.3; IsoId=Q9R1V6-7; Sequence=VSP_018238, VSP_018245; Name=6; Synonyms=ADAM22-G09, 22g+29.3; IsoId=Q9R1V6-8; Sequence=VSP_018245; Name=7; Synonyms=ADAM22-G10, 22g+29.1; IsoId=Q9R1V6-9; Sequence=VSP_018241; Name=8; Synonyms=ADAM22-G11, 22g(D27)+29.5+29.7; IsoId=Q9R1V6-10; Sequence=VSP_018238, VSP_018246; Name=9; Synonyms=ADAM22-G12, 22g+29.3+29.7; IsoId=Q9R1V6-11; Sequence=VSP_018247; Name=10; Synonyms=ADAM22-G17, 22G[27L]+29.3+29.7; IsoId=Q9R1V6-12; Sequence=VSP_018239, VSP_018242; Name=11; Synonyms=ADAM22-G18, 22g(D26)[27L]; IsoId=Q9R1V6-13; Sequence=VSP_018236, VSP_018239; Name=12; Synonyms=ADAM22-G19, 22g[27L]+29.5; IsoId=Q9R1V6-14; Sequence=VSP_018239, VSP_018243; Name=13; Synonyms=ADAM22-G20, 22g[27L]; IsoId=Q9R1V6-15; Sequence=VSP_018239; Name=14; Synonyms=ADAM22-G21, 22g(D26)[27S]; IsoId=Q9R1V6-16; Sequence=VSP_018234; Name=15; Synonyms=ADAM22-G22, 22g(D27)+29.7; IsoId=Q9R1V6-17; Sequence=VSP_018238, VSP_018244; Name=16; Synonyms=ADAM22-G23, 22g(D25D26D27); IsoId=Q9R1V6-18; Sequence=VSP_018233; Name=17; Synonyms=ADAM22-A05, Beta; IsoId=Q9R1V6-2; Sequence=VSP_018238, VSP_018248; Name=18; Synonyms=ADAM22-A13; IsoId=Q9R1V6-19; Sequence=VSP_018235, VSP_018248; Name=19; Synonyms=ADAM22-A15; IsoId=Q9R1V6-20; Sequence=VSP_018236, VSP_018248; Name=20; Synonyms=ADAM22-A04, Alpha; IsoId=Q9R1V6-1; Sequence=VSP_018248; Name=21; Synonyms=ADAM22-A16; IsoId=Q9R1V6-21; Sequence=VSP_018237, VSP_018240; Detected in juxtaparanodal zones in the central nervous system and at nerve terminal plexuses of basket cells in the cerebellum (at protein level) (PubMed:20089912, PubMed:26269648). Expressed at high levels in the brain. Strongly expressed in cerebellar granule cells and hippocampus. In spinal cord, expression is restricted to gray matter. The precursor is cleaved by a furin endopeptidase. Mice display severe ataxia within one week after birth and die before weaning, probably due to convulsions. They display marked hypomyelination of the peripheral nerves. metalloendopeptidase activity protein binding plasma membrane proteolysis metallopeptidase activity adult locomotory behavior Schwann cell differentiation membrane integral component of membrane myelination in peripheral nervous system axon gliogenesis cell projection glutamatergic synapse integral component of postsynaptic density membrane neurotransmitter receptor localization to postsynaptic specialization membrane uc008wjk.1 uc008wjk.2 uc008wjk.3 uc008wjk.4 uc008wjk.5 
ENSMUST00000088765.9 Zfp758 ENSMUST00000088765.9 zinc finger protein 758, transcript variant 8 (from RefSeq NR_177081.1) E9Q462 E9Q462_MOUSE ENSMUST00000088765.1 ENSMUST00000088765.2 ENSMUST00000088765.3 ENSMUST00000088765.4 ENSMUST00000088765.5 ENSMUST00000088765.6 ENSMUST00000088765.7 ENSMUST00000088765.8 NR_177081 Zfp758 uc008arr.1 uc008arr.2 uc008arr.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc008arr.1 uc008arr.2 uc008arr.3 
ENSMUST00000088778.5 Rtl8b ENSMUST00000088778.5 retrotransposon Gag like 8B (from RefSeq NM_001018063.2) Cxx1a Cxx1b ENSMUST00000088778.1 ENSMUST00000088778.2 ENSMUST00000088778.3 ENSMUST00000088778.4 NM_001018063 Q9D1F0 Q9D1F0_MOUSE Rtl8a Rtl8b uc009tff.1 uc009tff.2 molecular_function cellular_component biological_process uc009tff.1 uc009tff.2 
ENSMUST00000088779.5 Rtl8a ENSMUST00000088779.5 retrotransposon Gag like 8A (from RefSeq NM_024170.2) Cxx1a Cxx1b ENSMUST00000088779.1 ENSMUST00000088779.2 ENSMUST00000088779.3 ENSMUST00000088779.4 NM_024170 Q9D1F0 Q9D1F0_MOUSE Rtl8a Rtl8b uc009tfe.1 uc009tfe.2 uc009tfe.3 uc009tfe.4 uc009tfe.5 molecular_function cellular_component biological_process uc009tfe.1 uc009tfe.2 uc009tfe.3 uc009tfe.4 uc009tfe.5 
ENSMUST00000088785.6 Zfp566 ENSMUST00000088785.6 zinc finger protein 566 (from RefSeq NM_152814.2) ENSMUST00000088785.1 ENSMUST00000088785.2 ENSMUST00000088785.3 ENSMUST00000088785.4 ENSMUST00000088785.5 NM_152814 Q8VCI1 Q8VCI1_MOUSE Zfp566 uc009gdd.1 uc009gdd.2 uc009gdd.3 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc009gdd.1 uc009gdd.2 uc009gdd.3 
ENSMUST00000088787.7 Zfp948 ENSMUST00000088787.7 zinc finger protein 948, transcript variant 2 (from RefSeq NM_001357347.1) BC049807 ENSMUST00000088787.1 ENSMUST00000088787.2 ENSMUST00000088787.3 ENSMUST00000088787.4 ENSMUST00000088787.5 ENSMUST00000088787.6 NM_001357347 Q6DFU8 Q6DFU8_MOUSE Zfp948 uc008arc.1 uc008arc.2 uc008arc.3 uc008arc.4 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc008arc.1 uc008arc.2 uc008arc.3 uc008arc.4 
ENSMUST00000088796.3 Tex47 ENSMUST00000088796.3 testis expressed 47 (from RefSeq NM_027603.2) ENSMUST00000088796.1 ENSMUST00000088796.2 NM_027603 Q9D5W8 TEX47_MOUSE uc008wjf.1 uc008wjf.2 uc008wjf.3 molecular_function cellular_component biological_process uc008wjf.1 uc008wjf.2 uc008wjf.3 
ENSMUST00000088809.6 Gm7168 ENSMUST00000088809.6 predicted gene 7168 (from RefSeq NM_001122977.1) A0A0R4J163 A0A0R4J163_MOUSE ENSMUST00000088809.1 ENSMUST00000088809.2 ENSMUST00000088809.3 ENSMUST00000088809.4 ENSMUST00000088809.5 Gm7168 NM_001122977 uc008amu.1 uc008amu.2 May play a role in sperm motility, especially in the regulation of flagellar function. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily. protein kinase activity ATP binding protein phosphorylation uc008amu.1 uc008amu.2 
ENSMUST00000088811.7 Zfp160 ENSMUST00000088811.7 zinc finger protein 160 (from RefSeq NM_145483.2) E9Q459 E9Q459_MOUSE ENSMUST00000088811.1 ENSMUST00000088811.2 ENSMUST00000088811.3 ENSMUST00000088811.4 ENSMUST00000088811.5 ENSMUST00000088811.6 NM_145483 Zfp160 uc008aqk.1 uc008aqk.2 uc008aqk.3 uc008aqk.4 uc008aqk.5 Nucleus nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc008aqk.1 uc008aqk.2 uc008aqk.3 uc008aqk.4 uc008aqk.5 
ENSMUST00000088823.5 Mapk11 ENSMUST00000088823.5 mitogen-activated protein kinase 11 (from RefSeq NM_011161.5) ENSMUST00000088823.1 ENSMUST00000088823.2 ENSMUST00000088823.3 ENSMUST00000088823.4 MK11_MOUSE NM_011161 Prkm11 Q569F1 Q9WUI1 uc007xfp.1 uc007xfp.2 uc007xfp.3 uc007xfp.4 uc007xfp.5 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B- binding sites marking promoters for increased NF-kappa-B recruitment. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation on threonine and tyrosine by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 induced by environmental stress. HDAC3 interacts directly and selectively with MAPK11 to repress ATF2 transcriptional activity, and regulate TNF gene expression in LPS-stimulated cells. Inhibited by SB203580 and pyridinyl-imidazole related compounds. Interacts with HDAC3 and DUSP16. Q9WUI1; P47811: Mapk14; NbExp=10; IntAct=EBI-645081, EBI-298727; Cytoplasm Nucleus The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6, which activates the enzyme. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol protein phosphorylation regulation of gene expression positive regulation of gene expression kinase activity phosphorylation transferase activity intracellular signal transduction stress-activated MAPK cascade regulation of cardiac muscle cell proliferation negative regulation of cardiac muscle cell proliferation cellular response to interleukin-1 cellular response to virus positive regulation of interleukin-12 secretion uc007xfp.1 uc007xfp.2 uc007xfp.3 uc007xfp.4 uc007xfp.5 
ENSMUST00000088827.8 Mapk12 ENSMUST00000088827.8 mitogen-activated protein kinase 12, transcript variant 1 (from RefSeq NM_013871.4) ENSMUST00000088827.1 ENSMUST00000088827.2 ENSMUST00000088827.3 ENSMUST00000088827.4 ENSMUST00000088827.5 ENSMUST00000088827.6 ENSMUST00000088827.7 MK12_MOUSE NM_013871 O08911 Q9D0M4 Sapk3 uc007xfl.1 uc007xfl.2 uc007xfl.3 uc007xfl.4 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down- regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12- signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions.; Activated by phosphorylation on threonine and tyrosine. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK12 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK12 activator in response to TNF-alpha. Monomer. Interacts with the PDZ domain of the syntrophin SNTA1 (By similarity). Interacts with SH3BP5, LIN7C, SCRIB and SYNJ2BP (By similarity). Interacts with PTPN4; this interaction induces the activation of PTPN4 phosphatase activity. Cytoplasm Nucleus Mitochondrion Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma. Highly expressed in skeletal muscle. Also expressed in the heart, particularly in cardiac myocytes, lung, thymus and testes. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K3/MKK3 and MAP2K6/MKK6, which activates the enzyme. Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. MAPK cascade nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity ATP binding nucleus nucleoplasm cytoplasm mitochondrion protein phosphorylation cell cycle regulation of gene expression kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction myoblast differentiation negative regulation of cell cycle metal ion binding uc007xfl.1 uc007xfl.2 uc007xfl.3 uc007xfl.4 
ENSMUST00000088880.11 Gm6994 ENSMUST00000088880.11 predicted gene 6994 (from RefSeq NR_033141.1) ENSMUST00000088880.1 ENSMUST00000088880.10 ENSMUST00000088880.2 ENSMUST00000088880.3 ENSMUST00000088880.4 ENSMUST00000088880.5 ENSMUST00000088880.6 ENSMUST00000088880.7 ENSMUST00000088880.8 ENSMUST00000088880.9 NR_033141 uc007usa.1 uc007usa.2 uc007usa.3 uc007usa.4 uc007usa.1 uc007usa.2 uc007usa.3 uc007usa.4 
ENSMUST00000088896.10 Tmcc1 ENSMUST00000088896.10 transmembrane and coiled coil domains 1, transcript variant 1 (from RefSeq NM_177412.1) ENSMUST00000088896.1 ENSMUST00000088896.2 ENSMUST00000088896.3 ENSMUST00000088896.4 ENSMUST00000088896.5 ENSMUST00000088896.6 ENSMUST00000088896.7 ENSMUST00000088896.8 ENSMUST00000088896.9 Kiaa0779 NM_177412 Q69ZZ6 Q8CEF4 TMCC1_MOUSE uc009djq.1 uc009djq.2 uc009djq.3 uc009djq.4 Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission. Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. May form homodimers and heterodimers with TMCC2 or TMCC3 via the coiled-coil domains. Interacts with ribosomal proteins RPL4 and RPS6. Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Specifically localizes to contact sites between the endoplasmic reticulum and endosomes that are spatially and temporally linked to endosome fission. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q69ZZ6-1; Sequence=Displayed; Name=2; IsoId=Q69ZZ6-2; Sequence=VSP_019590, VSP_019591; Name=3; IsoId=Q69ZZ6-3; Sequence=VSP_019589; Belongs to the TEX28 family. Sequence=BAD32300.1; Type=Erroneous initiation; Evidence=; Sequence=BAE32665.1; Type=Erroneous initiation; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane rough endoplasmic reticulum cytosol endoplasmic reticulum organization membrane integral component of membrane endosomal transport protein homodimerization activity protein heterodimerization activity protein homooligomerization protein heterooligomerization membrane fission endosome membrane tubulation uc009djq.1 uc009djq.2 uc009djq.3 uc009djq.4 
ENSMUST00000088898.11 Zfp280c ENSMUST00000088898.11 zinc finger protein 280C, transcript variant 2 (from RefSeq NM_001166648.2) B1AU28 B1AU29 ENSMUST00000088898.1 ENSMUST00000088898.10 ENSMUST00000088898.2 ENSMUST00000088898.3 ENSMUST00000088898.4 ENSMUST00000088898.5 ENSMUST00000088898.6 ENSMUST00000088898.7 ENSMUST00000088898.8 ENSMUST00000088898.9 Kiaa1584 NM_001166648 Q6P3Y5 Q6ZPM2 Q8K145 Suhw3 Z280C_MOUSE Znf280c uc009tcl.1 uc009tcl.2 uc009tcl.3 May function as a transcription factor. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P3Y5-1; Sequence=Displayed; Name=2; IsoId=Q6P3Y5-2; Sequence=VSP_017620, VSP_017621; Name=3; IsoId=Q6P3Y5-3; Sequence=VSP_017619; Sequence=BAC98209.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009tcl.1 uc009tcl.2 uc009tcl.3 
ENSMUST00000088904.10 Espnl ENSMUST00000088904.10 espin-like (from RefSeq NM_001033292.4) ENSMUST00000088904.1 ENSMUST00000088904.2 ENSMUST00000088904.3 ENSMUST00000088904.4 ENSMUST00000088904.5 ENSMUST00000088904.6 ENSMUST00000088904.7 ENSMUST00000088904.8 ENSMUST00000088904.9 ESPNL_MOUSE Gm556 NM_001033292 Q3UYR4 uc007cah.1 uc007cah.2 uc007cah.3 Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. Interacts with MYO3A (via C-terminus). Interacts with MYO3B (via C-terminus). Cell projection, stereocilium Expressed in inner ear hair cells (PubMed:25582750). Expressed in utricle hair bundles (at protein level). Expressed in choclea (at protein level) (PubMed:26926603). actin binding protein binding cytoplasm sensory perception of sound stereocilium stereocilium tip cell projection actin filament binding actin filament bundle assembly filamentous actin uc007cah.1 uc007cah.2 uc007cah.3 
ENSMUST00000088921.6 Bpifb9b ENSMUST00000088921.6 BPI fold containing family B, member 9B (from RefSeq NM_001025574.1) 5430413K10Rik A2AJD1 A2AJD1_MOUSE Bpifb9b ENSMUST00000088921.1 ENSMUST00000088921.2 ENSMUST00000088921.3 ENSMUST00000088921.4 ENSMUST00000088921.5 NM_001025574 uc008nja.1 uc008nja.2 uc008nja.3 uc008nja.4 molecular_function cellular_component sensory perception of smell biological_process lipid binding uc008nja.1 uc008nja.2 uc008nja.3 uc008nja.4 
ENSMUST00000088922.5 Gtf2f2 ENSMUST00000088922.5 general transcription factor IIF, polypeptide 2, transcript variant 1 (from RefSeq NM_026816.4) ENSMUST00000088922.1 ENSMUST00000088922.2 ENSMUST00000088922.3 ENSMUST00000088922.4 NM_026816 Q8R0A0 T2FB_MOUSE uc007urb.1 uc007urb.2 TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. Heterodimer of an alpha and a beta subunit. Interacts with HTATSF1 and URI1 (By similarity). Interacts with GPBP1. Interacts with GTF2B (via N-terminus); this interaction is inhibited in presence of GTF2F1 (By similarity). Nucleus Belongs to the TFIIF beta subunit family. nucleotide binding DNA binding DNA helicase activity helicase activity ATP binding nucleus transcription factor TFIIF complex holo TFIIH complex transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter microtubule cytoskeleton hydrolase activity DNA duplex unwinding positive regulation of transcription elongation from RNA polymerase II promoter positive regulation of RNA polymerase II transcriptional preinitiation complex assembly positive regulation of transcription from RNA polymerase II promoter transcriptional preinitiation complex uc007urb.1 uc007urb.2 
ENSMUST00000088924.7 Bpifb9a ENSMUST00000088924.7 BPI fold containing family B, member 9A (from RefSeq NM_175167.4) A2AJD0 Bpifb9a ENSMUST00000088924.1 ENSMUST00000088924.2 ENSMUST00000088924.3 ENSMUST00000088924.4 ENSMUST00000088924.5 ENSMUST00000088924.6 NM_175167 Q5XK13 Q80XI7 Q8CDY1 VOME_MOUSE uc008niz.1 uc008niz.2 uc008niz.3 uc008niz.4 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80XI7-1; Sequence=Displayed; Name=2; IsoId=Q80XI7-2; Sequence=VSP_016661; Expressed in lung. Not detected in other tissues tested (at protein level). N-glycosylated. The N-glycans consist mainly of complex sialylated and fucosylated biantennary structures. [Isoform 2]: May be due to intron retention. molecular_function cellular_component extracellular region sensory perception of smell biological_process lipid binding uc008niz.1 uc008niz.2 uc008niz.3 uc008niz.4 
ENSMUST00000088931.10 Gramd4 ENSMUST00000088931.10 GRAM domain containing 4, transcript variant 1 (from RefSeq NM_172611.5) B2RTC1 Dip ENSMUST00000088931.1 ENSMUST00000088931.2 ENSMUST00000088931.3 ENSMUST00000088931.4 ENSMUST00000088931.5 ENSMUST00000088931.6 ENSMUST00000088931.7 ENSMUST00000088931.8 ENSMUST00000088931.9 GRAM4_MOUSE Gramd4 Kiaa0767 NM_172611 Q6ZQ52 Q8CB44 Q8VDL6 uc007xdv.1 uc007xdv.2 uc007xdv.3 uc007xdv.4 uc007xdv.5 Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (By similarity). Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (PubMed:25917084). Interacts with RTN4 (isoform B). Mitochondrion membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Colocalizes with COX4I1. It is uncertain whether Met-1 or Met-52 is the initiator. Sequence=AAH21523.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC98019.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence=; protein binding mitochondrion endoplasmic reticulum endoplasmic reticulum membrane apoptotic process membrane integral component of membrane mitochondrial membrane negative regulation of toll-like receptor 9 signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic process uc007xdv.1 uc007xdv.2 uc007xdv.3 uc007xdv.4 uc007xdv.5 
ENSMUST00000088935.4 Zdhhc9 ENSMUST00000088935.4 Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling. (from UniProt P59268) BC090832 ENSMUST00000088935.1 ENSMUST00000088935.2 ENSMUST00000088935.3 P59268 Q5BL19 ZDHC9_MOUSE uc009tby.1 uc009tby.2 uc009tby.3 Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling. Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Interacts with GOLGA7. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein The DHHC domain is required for palmitoyltransferase activity. Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. Golgi membrane palmitoyltransferase complex endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity intrinsic component of Golgi membrane Ras palmitoyltransferase activity uc009tby.1 uc009tby.2 uc009tby.3 
ENSMUST00000088940.6 Tmem181a ENSMUST00000088940.6 transmembrane protein 181A, transcript variant 1 (from RefSeq NM_001033178.3) ENSMUST00000088940.1 ENSMUST00000088940.2 ENSMUST00000088940.3 ENSMUST00000088940.4 ENSMUST00000088940.5 Gpr178 NM_001033178 Q3U3W2 Q3U3W2_MOUSE Tmem181 Tmem181a uc008agj.1 uc008agj.2 uc008agj.3 Membrane ; Multi- pass membrane protein cellular_component pathogenesis toxic substance binding membrane integral component of membrane uc008agj.1 uc008agj.2 uc008agj.3 
ENSMUST00000088950.8 Bpifb3 ENSMUST00000088950.8 BPI fold containing family B, member 3, transcript variant 1 (from RefSeq NM_194357.2) A2APD1 BPIB3_MOUSE Bpifb3 ENSMUST00000088950.1 ENSMUST00000088950.2 ENSMUST00000088950.3 ENSMUST00000088950.4 ENSMUST00000088950.5 ENSMUST00000088950.6 ENSMUST00000088950.7 Lplunc3 NM_194357 Q80ZU7 Rya3 uc008nip.1 uc008nip.2 May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity). Secreted Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. extracellular region cytoplasm biological_process lipid binding innate immune response uc008nip.1 uc008nip.2 
ENSMUST00000088955.12 Bpifb6 ENSMUST00000088955.12 BPI fold containing family B, member 6 (from RefSeq NM_199303.2) A2APD0 BPIB6_MOUSE Bpil3 ENSMUST00000088955.1 ENSMUST00000088955.10 ENSMUST00000088955.11 ENSMUST00000088955.2 ENSMUST00000088955.3 ENSMUST00000088955.4 ENSMUST00000088955.5 ENSMUST00000088955.6 ENSMUST00000088955.7 ENSMUST00000088955.8 ENSMUST00000088955.9 Gm119 NM_199303 Q80ZU8 Q8BU51 uc008nio.1 uc008nio.2 uc008nio.3 uc008nio.4 Secreted Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. Sequence=BAC39978.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cellular_component extracellular region biological_process lipid binding uc008nio.1 uc008nio.2 uc008nio.3 uc008nio.4 
ENSMUST00000088970.7 Lrch1 ENSMUST00000088970.7 leucine-rich repeats and calponin homology (CH) domain containing 1, transcript variant 1 (from RefSeq NM_001033439.3) Chdc1 E9QLJ4 ENSMUST00000088970.1 ENSMUST00000088970.2 ENSMUST00000088970.3 ENSMUST00000088970.4 ENSMUST00000088970.5 ENSMUST00000088970.6 Kiaa1016 LRCH1_MOUSE NM_001033439 P62046 uc007uqf.1 uc007uqf.2 uc007uqf.3 Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration in response to chemokine stimulation. Interacts (via LRR repeats) with unphosphorylated DOCK8 (via DHR-2 domain); the interaction prevents the association between DOCK8 and CDC42. Cytoplasm No visible phenotype. Mice are viable, fertile and have normal CD4(+) T-cell populations in lymph nodes and spleen. In an experimental autoimmune encephalomyelitis (EAE) disease model, the symptoms, such as paralysis, are more severe. Sequence=BAC98074.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding cytoplasm negative regulation of GTPase activity cellular response to chemokine negative regulation of T cell migration uc007uqf.1 uc007uqf.2 uc007uqf.3 
ENSMUST00000088987.3 Hrh1 ENSMUST00000088987.3 histamine receptor H1, transcript variant 3 (from RefSeq NM_008285.5) Bphs ENSMUST00000088987.1 ENSMUST00000088987.2 HRH1_MOUSE NM_008285 P70174 Q91V75 Q91XN0 Q91XN1 Q91XN2 Q91XN3 uc009dhw.1 uc009dhw.2 uc009dhw.3 uc009dhw.4 In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Involved in circadian rhythm of locomotor activity and exploratory behavior. Also involved in responsiveness to pertussis toxin through its control of susceptibility to histamine hypersensitivity and enhancement of antigen-specific delayed-type hypersensitivity responses. Cell membrane; Multi-pass membrane protein. Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor down-regulation. Strains C3H/HeJ and CBA/J are resistant to vasoactive amine sensitization elicited by histamine (VAASH) which is induced by pertussis toxin. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity histamine receptor activity G-protein coupled serotonin receptor activity cytosol plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission memory visual learning negative regulation of steroid biosynthetic process calcium ion transmembrane transporter activity membrane integral component of membrane dendrite neurotransmitter receptor activity regulation of vascular permeability positive regulation of nitric oxide biosynthetic process positive regulation of vasoconstriction regulation of synaptic plasticity eosinophil chemotaxis rhythmic process histamine binding calcium ion import calcium ion transmembrane transport cellular response to histamine manganese ion transmembrane transport uc009dhw.1 uc009dhw.2 uc009dhw.3 uc009dhw.4 
ENSMUST00000089015.10 Mas1 ENSMUST00000089015.10 MAS1 oncogene (from RefSeq NM_008552.5) ENSMUST00000089015.1 ENSMUST00000089015.2 ENSMUST00000089015.3 ENSMUST00000089015.4 ENSMUST00000089015.5 ENSMUST00000089015.6 ENSMUST00000089015.7 ENSMUST00000089015.8 ENSMUST00000089015.9 Mas1 Mgra NM_008552 Q0VB49 Q0VB49_MOUSE uc033hat.1 uc033hat.2 uc033hat.3 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. negative regulation of protein phosphorylation G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway spermatogenesis positive regulation of cell proliferation male gonad development cell surface response to activity membrane integral component of membrane hippocampus development response to gonadotropin response to drug response to peptide hormone positive regulation of DNA replication positive regulation of inositol phosphate biosynthetic process protein kinase C signaling cellular response to peptide hormone stimulus uc033hat.1 uc033hat.2 uc033hat.3 
ENSMUST00000089017.12 Fndc3a ENSMUST00000089017.12 fibronectin type III domain containing 3A (from RefSeq NM_207636.3) D14Ertd453e ENSMUST00000089017.1 ENSMUST00000089017.10 ENSMUST00000089017.11 ENSMUST00000089017.2 ENSMUST00000089017.3 ENSMUST00000089017.4 ENSMUST00000089017.5 ENSMUST00000089017.6 ENSMUST00000089017.7 ENSMUST00000089017.8 ENSMUST00000089017.9 FND3A_MOUSE Fndc3 Kiaa0970 NM_207636 Q2VEY7 Q3T9K5 Q6ZQ15 Q811D3 Q8BME4 Q8BTM3 Q8BX90 uc007upg.1 uc007upg.2 uc007upg.3 Mediates spermatid-Sertoli adhesion during spermatogenesis. Golgi apparatus membrane ; Single- pass membrane protein Testis. Localizes to the acrosome of spermatids, as well as to Leydig cells. Can be detected on the acrosome beginning at steps 2-3 and continuing until step 12 of spermiogenesis. Belongs to the FNDC3 family. Golgi membrane acrosomal vesicle Golgi apparatus cytosol spermatid development fertilization vesicle membrane membrane integral component of membrane cytoplasmic vesicle Sertoli cell development cell-cell adhesion uc007upg.1 uc007upg.2 uc007upg.3 
ENSMUST00000089018.11 Tatdn2 ENSMUST00000089018.11 TatD DNase domain containing 2, transcript variant 6 (from RefSeq NR_177930.1) ENSMUST00000089018.1 ENSMUST00000089018.10 ENSMUST00000089018.2 ENSMUST00000089018.3 ENSMUST00000089018.4 ENSMUST00000089018.5 ENSMUST00000089018.6 ENSMUST00000089018.7 ENSMUST00000089018.8 ENSMUST00000089018.9 F8VQE6 F8VQE6_MOUSE NR_177930 Tatdn2 uc009dhg.1 uc009dhg.2 uc009dhg.3 Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. nucleus cytosol DNA metabolic process nuclear speck hydrolase activity, acting on ester bonds endodeoxyribonuclease activity, producing 5'-phosphomonoesters uc009dhg.1 uc009dhg.2 uc009dhg.3 
ENSMUST00000089027.3 Tm9sf4 ENSMUST00000089027.3 transmembrane 9 superfamily member 4 (from RefSeq NM_133847.3) ENSMUST00000089027.1 ENSMUST00000089027.2 Kiaa0255 NM_133847 Q2TBF8 Q3TB27 Q8BH24 Q8BU80 Q8BXB4 Q8CHH4 TM9S4_MOUSE uc008nhe.1 uc008nhe.2 uc008nhe.3 Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Membrane ; Multi-pass membrane protein Golgi apparatus Early endosome Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. response to hypoxia molecular_function endosome early endosome Golgi apparatus phagocytosis cell adhesion membrane integral component of membrane regulation of intracellular pH vacuolar proton-transporting V-type ATPase complex assembly positive regulation of protein exit from endoplasmic reticulum protein localization to membrane positive regulation of protein localization to cell surface uc008nhe.1 uc008nhe.2 uc008nhe.3 
ENSMUST00000089049.4 Nudt18 ENSMUST00000089049.4 nudix hydrolase 18, transcript variant 1 (from RefSeq NM_153136.5) ENSMUST00000089049.1 ENSMUST00000089049.2 ENSMUST00000089049.3 NM_153136 NUD18_MOUSE Nudt18 Q3U2V3 Q8C223 Q8K1Y7 uc007uok.1 uc007uok.2 uc007uok.3 Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. Reaction=8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate; Xref=Rhea:RHEA:32063, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:63224, ChEBI:CHEBI:63715; EC=3.6.1.58; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32064; Evidence=; Reaction=8-oxo-dADP + H2O = 8-oxo-dAMP + H(+) + phosphate; Xref=Rhea:RHEA:35219, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:71361, ChEBI:CHEBI:71362; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35220; Evidence=; Reaction=2-oxo-dADP + H2O = 2-oxo-dAMP + H(+) + phosphate; Xref=Rhea:RHEA:35223, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:63212, ChEBI:CHEBI:71363; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35224; Evidence=; Reaction=8-oxo-GDP + H2O = 8-oxo-GMP + H(+) + phosphate; Xref=Rhea:RHEA:62356, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:143554, ChEBI:CHEBI:145694; EC=3.6.1.58; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62357; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U2V3-1; Sequence=Displayed; Name=2; IsoId=Q3U2V3-2; Sequence=VSP_032279; Name=3; IsoId=Q3U2V3-3; Sequence=VSP_032278; Belongs to the Nudix hydrolase family. magnesium ion binding cellular_component nucleotide metabolic process hydrolase activity 8-oxo-dGDP phosphatase activity 8-oxo-GDP phosphatase activity 8-hydroxy-dADP phosphatase activity dADP catabolic process dGDP catabolic process GDP catabolic process metal ion binding uc007uok.1 uc007uok.2 uc007uok.3 
ENSMUST00000089059.9 H13 ENSMUST00000089059.9 histocompatibility 13, transcript variant 1 (from RefSeq NM_001159551.2) A3KGS1 ENSMUST00000089059.1 ENSMUST00000089059.2 ENSMUST00000089059.3 ENSMUST00000089059.4 ENSMUST00000089059.5 ENSMUST00000089059.6 ENSMUST00000089059.7 ENSMUST00000089059.8 HM13_MOUSE Hm13 NM_001159551 O19444 Psl3 Q15K37 Q3TXP0 Q542R3 Q811Z6 Q8HWA9 Q8HWB5 Q9CQA4 Q9CSK9 Q9D8V0 uc008ngc.1 uc008ngc.2 uc008ngc.3 uc008ngc.4 Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (By similarity). May play a role in graft rejection (PubMed:9354467). Monomer. Homodimer (By similarity). Interacts with RNF139 (PubMed:19720873). Interacts with DERL1 and XBP1 isoform 1 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein ; Lumenal side [Isoform 4]: Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=SPP-alpha; IsoId=Q9D8V0-1; Sequence=Displayed; Name=2; IsoId=Q9D8V0-2; Sequence=VSP_005199, VSP_005200; Name=3; IsoId=Q9D8V0-3; Sequence=VSP_005201, VSP_005202; Name=4; Synonyms=SPP-beta; IsoId=Q9D8V0-4; Sequence=VSP_039805; Widely expressed with highest levels in liver and kidney. In the brain, expressed predominantly in hippocampus, amygdala, piriform cortex, choroid plexus and arcuate nucleus of the hypothalamic area. Isoform 1 is more strongly expressed than isoform 4 in most tissues except brain and skeletal muscle where isoform 4 is the dominant isoform and in testis where isoform 1 and isoform 4 are expressed at similar levels. In the brain, isoform 4 is not detected in the choroid plexus. In the embryo, expression starts at day 6.5. The first transmembrane domain may act as a type I signal anchor. The PAL motif is required for normal active site conformation. Belongs to the peptidase A22B family. in utero embryonic development aspartic-type endopeptidase activity endoplasmic reticulum endoplasmic reticulum membrane rough endoplasmic reticulum plasma membrane signal peptide processing proteolysis peptidase activity cell surface membrane integral component of membrane hydrolase activity ubiquitin protein ligase binding membrane protein proteolysis Derlin-1 retrotranslocation complex aspartic endopeptidase activity, intramembrane cleaving protein homodimerization activity integral component of cytoplasmic side of endoplasmic reticulum membrane integral component of lumenal side of endoplasmic reticulum membrane membrane protein proteolysis involved in retrograde protein transport, ER to cytosol uc008ngc.1 uc008ngc.2 uc008ngc.3 uc008ngc.4 
ENSMUST00000089062.8 Rhox9 ENSMUST00000089062.8 reproductive homeobox 9 (from RefSeq NM_023894.1) ENSMUST00000089062.1 ENSMUST00000089062.2 ENSMUST00000089062.3 ENSMUST00000089062.4 ENSMUST00000089062.5 ENSMUST00000089062.6 ENSMUST00000089062.7 Gpbox NM_023894 Psx2 Q9EQM5 Q9EQM5_MOUSE Rhox9 uc009szj.1 uc009szj.2 Nucleus DNA binding cellular_component nucleus biological_process uc009szj.1 uc009szj.2 
ENSMUST00000089075.6 Rhox4e ENSMUST00000089075.6 reproductive homeobox 4E (from RefSeq NM_201236.3) ENSMUST00000089075.1 ENSMUST00000089075.2 ENSMUST00000089075.3 ENSMUST00000089075.4 ENSMUST00000089075.5 NM_201236 Q504P9 Q504P9_MOUSE Rhox4.5 Rhox4e uc009syz.1 uc009syz.2 uc009syz.3 Nucleus DNA binding cellular_component nucleus biological_process uc009syz.1 uc009syz.2 uc009syz.3 
ENSMUST00000089085.10 Pde10a ENSMUST00000089085.10 phosphodiesterase 10A, transcript variant 2 (from RefSeq NM_011866.2) ENSMUST00000089085.1 ENSMUST00000089085.2 ENSMUST00000089085.3 ENSMUST00000089085.4 ENSMUST00000089085.5 ENSMUST00000089085.6 ENSMUST00000089085.7 ENSMUST00000089085.8 ENSMUST00000089085.9 NM_011866 PDE10_MOUSE Q3TLU6 Q3TRG6 Q69C21 Q8CA95 Q9WVI1 uc008ajs.1 uc008ajs.2 uc008ajs.3 Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (PubMed:10359840). Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10359840). May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:10359840, PubMed:14751289, PubMed:27058446). Reaction=a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'- phosphate + H(+); Xref=Rhea:RHEA:14653, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57867, ChEBI:CHEBI:58464; EC=3.1.4.17; Evidence=; Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; Evidence=; Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, ChEBI:CHEBI:58115; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Kinetic parameters: KM=0.05 uM for cAMP ; KM=3 uM for cGMP ; Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1. Homodimer. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8CA95-1; Sequence=Displayed; Name=2; IsoId=Q8CA95-2; Sequence=VSP_035917; Name=3; IsoId=Q8CA95-3; Sequence=VSP_035916; Name=4; IsoId=Q8CA95-4; Sequence=VSP_035915, VSP_035918; Detected in striatum (at protein level). Detected in testis and brain. Down-regulated by the expression of a huntingtin (HD) gene with an expanded polyglutamine repeat prior to the onset of neurological symptoms related to Huntington disease. The tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity (By similarity). Composed of a C-terminal catalytic domain containing two divalent metal sites and an N-terminal regulatory domain which contains one cyclic nucleotide-binding region. Belongs to the cyclic nucleotide phosphodiesterase family. nucleotide binding catalytic activity cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity cytoplasm cAMP catabolic process signal transduction phosphoric diester hydrolase activity metabolic process regulation of protein kinase A signaling negative regulation of cGMP-mediated signaling membrane hydrolase activity cAMP binding cGMP binding neuronal cell body perikaryon regulation of cAMP-mediated signaling negative regulation of cAMP-mediated signaling cGMP catabolic process metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity uc008ajs.1 uc008ajs.2 uc008ajs.3 
ENSMUST00000089097.3 Krtap20-24 ENSMUST00000089097.3 Interacts with hair keratins. (from UniProt Q3V4B6) 1110057P08Rik AK004289 ENSMUST00000089097.1 ENSMUST00000089097.2 Q3V4B6 Q3V4B6_MOUSE uc289fwb.1 uc289fwb.2 Interacts with hair keratins. molecular_function cellular_component biological_process uc289fwb.1 uc289fwb.2 
ENSMUST00000089098.2 Krtap20-22 ENSMUST00000089098.2 Interacts with hair keratins. (from UniProt D3YX18) D3YX18 D3YX18_MOUSE ENSMUST00000089098.1 Gm7735 uc289fwa.1 uc289fwa.2 Interacts with hair keratins. molecular_function cellular_component biological_process uc289fwa.1 uc289fwa.2 
ENSMUST00000089104.3 Krtap6-6 ENSMUST00000089104.3 RIKEN cDNA 1110025L11 gene (from RefSeq NM_001276278.1) 1110025L11Rik ENSMUST00000089104.1 ENSMUST00000089104.2 Gm10228 Krtap6-1 NM_001276278 O09048 O09048_MOUSE uc033gzq.1 uc033gzq.2 uc033gzq.3 uc033gzq.4 Belongs to the KRTAP type 6 family. molecular_function cellular_component intermediate filament biological_process keratinization uc033gzq.1 uc033gzq.2 uc033gzq.3 uc033gzq.4 
ENSMUST00000089105.4 Krtap6-7 ENSMUST00000089105.4 predicted gene 10228 (from RefSeq NM_001270487.1) 1110025L11Rik ENSMUST00000089105.1 ENSMUST00000089105.2 ENSMUST00000089105.3 Gm10228 Krtap6-1 NM_001270487 O09048 O09048_MOUSE uc033gzp.1 uc033gzp.2 Belongs to the KRTAP type 6 family. molecular_function cellular_component intermediate filament biological_process keratinization uc033gzp.1 uc033gzp.2 
ENSMUST00000089106.4 Krtap6-3 ENSMUST00000089106.4 predicted gene 10229 (from RefSeq NM_001199334.2) ENSMUST00000089106.1 ENSMUST00000089106.2 ENSMUST00000089106.3 Gm10229 Krtap6-1 NM_001199334 O08631 O08631_MOUSE uc012ahy.1 uc012ahy.2 uc012ahy.3 Belongs to the KRTAP type 6 family. molecular_function cellular_component intermediate filament biological_process keratinization uc012ahy.1 uc012ahy.2 uc012ahy.3 
ENSMUST00000089111.5 Krtap13-20 ENSMUST00000089111.5 RIKEN cDNA 2310034C09 gene (from RefSeq NM_054100.3) 2310034C09Rik ENSMUST00000089111.1 ENSMUST00000089111.2 ENSMUST00000089111.3 ENSMUST00000089111.4 NM_054100 Q9D746 Q9D746_MOUSE uc007zvd.1 uc007zvd.2 uc007zvd.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the PMG family. molecular_function cellular_component biological_process uc007zvd.1 uc007zvd.2 uc007zvd.3 
ENSMUST00000089112.6 Tcf15 ENSMUST00000089112.6 transcription factor 15 (from RefSeq NM_009328.2) Bhlhec2 ENSMUST00000089112.1 ENSMUST00000089112.2 ENSMUST00000089112.3 ENSMUST00000089112.4 ENSMUST00000089112.5 NM_009328 Q60756 Q60788 TCF15_MOUSE Tcf15 uc008nex.1 uc008nex.2 uc008nex.3 uc008nex.4 Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency (PubMed:7597044, PubMed:8955271, PubMed:23395635, PubMed:32669716, PubMed:24038871). Essential for the mesenchymal to epithelial transition associated with somite formation (PubMed:7597044, PubMed:8955271, PubMed:24038871). Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles (PubMed:8955271). Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition (PubMed:24038871). Also plays a key role in regulation of stem cell pluripotency (PubMed:23395635, PubMed:32669716). Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation (PubMed:23395635). Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long- term self-renewal (PubMed:32669716). Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (PubMed:25561514). Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes (PubMed:15226298, PubMed:23395635). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein, such as TCF3/E12 (PubMed:15226298, PubMed:23395635). Interacts with MEOX2 (PubMed:25561514). Nucleus Expressed in heart and skeletal muscle (PubMed:8041747, PubMed:7597044). Specifically expressed in a subpopulation of embryonic stem cells (ESCs), that are still undifferentiated but primed for ifferentiation (PubMed:23395635). Expressed in hematopoietic stem cells (HSCs) (PubMed:32669716). Expressed in the embryonic day 4.5 embryo (PubMed:23395635). Expressed in paraxial mesoderm and developing somites (PubMed:7729571). At 7.5 dpc, low expression is detected in a subdomain of the primitive mesoderm (PubMed:8041747). At 8.5 dpc, expressed at high levels throughout the uncompartmentalized epithelial somites and in the rostral paraxial mesoderm (PubMed:8041747). By 9.5 dpc, expression is confined to the somite and is most prominent in the myotome and dermatome (PubMed:8041747). At 10 dpc, expression in somite declines in the myotome but persists at high level in the dermatome (PubMed:8041747). At 10.5 dpc, expression is seen only in the somites in the caudal portion of the embryo (PubMed:8041747). Lethality within an hour of birth, possibly caused by rib defects that lead to respiratory distress (PubMed:8955271). At birth, neonates display obvious caudal agenesis with tails that are shortened and curled (PubMed:8955271). They also lack the normal cervical flexure of the vertebral column, and their hindlimbs are curved towards the midline (PubMed:8955271). Neonates also display low-set ears, a thickened neck and loose skin (PubMed:8955271). Defects are caused by impaired formation of somites: cells from the paraxial mesoderm are unable to form epithelia, preventing formation of somites (PubMed:8955271). In the absence of normal somites, the axial skeleton and skeletal muscle form but are improperly patterned (PubMed:8955271). Hematopoietic stem cells (HSCs) show a specific loss of quiescent stem cells (PubMed:32669716). somitogenesis respiratory system process DNA binding nucleus multicellular organism development muscle organ development anterior/posterior pattern specification regulation of gene expression post-anal tail morphogenesis eating behavior ear development skin development establishment of epithelial cell apical/basal polarity positive regulation of transcription from RNA polymerase II promoter protein dimerization activity paraxial mesoderm development muscle organ morphogenesis skeletal system morphogenesis neuromuscular process controlling posture mesenchymal to epithelial transition RNA polymerase II transcription factor complex regulation of extracellular matrix organization RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding uc008nex.1 uc008nex.2 uc008nex.3 uc008nex.4 
ENSMUST00000089129.7 Cyp2d9 ENSMUST00000089129.7 cytochrome P450, family 2, subfamily d, polypeptide 9 (from RefSeq NM_010006.2) CP2D9_MOUSE Cyp2d-9 ENSMUST00000089129.1 ENSMUST00000089129.2 ENSMUST00000089129.3 ENSMUST00000089129.4 ENSMUST00000089129.5 ENSMUST00000089129.6 NM_010006 P11714 Q64489 Q921V1 uc007wzg.1 uc007wzg.2 uc007wzg.3 uc007wzg.4 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen arachidonic acid metabolic process heme binding organelle membrane exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc007wzg.1 uc007wzg.2 uc007wzg.3 uc007wzg.4 
ENSMUST00000089157.11 Cenpm ENSMUST00000089157.11 centromere protein M, transcript variant 1 (from RefSeq NM_025639.4) CENPM_MOUSE ENSMUST00000089157.1 ENSMUST00000089157.10 ENSMUST00000089157.2 ENSMUST00000089157.3 ENSMUST00000089157.4 ENSMUST00000089157.5 ENSMUST00000089157.6 ENSMUST00000089157.7 ENSMUST00000089157.8 ENSMUST00000089157.9 NM_025639 Pane1 Q3THN3 Q91VS6 Q9CQA0 uc007wyn.1 uc007wyn.2 uc007wyn.3 uc007wyn.4 This gene encodes a protein that is present in the nucleus of actively growing cells but is excluded from the nucleus during cell division or during growth arrest as a result of contact inhibition. In human, this protein is a component of the CENP-A nucleosome-associated complex that regulates kinetochore protein assembly, mitotic cell-cycle progression, and chromosome segregation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS (By similarity). Nucleus Cytoplasm Chromosome, centromere, kinetochore Note=Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells. Localizes in the kinetochore domain of centromeres (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQA0-1; Sequence=Displayed; Name=2; IsoId=Q9CQA0-2; Sequence=VSP_020440; chromosome, centromeric region kinetochore condensed chromosome kinetochore molecular_function nucleus chromosome cytoplasm cytosol biological_process uc007wyn.1 uc007wyn.2 uc007wyn.3 uc007wyn.4 
ENSMUST00000089162.5 Edem1 ENSMUST00000089162.5 ER degradation enhancer, mannosidase alpha-like 1 (from RefSeq NM_138677.2) EDEM1_MOUSE ENSMUST00000089162.1 ENSMUST00000089162.2 ENSMUST00000089162.3 ENSMUST00000089162.4 Edem NM_138677 Q8CFM1 Q925U4 uc009ddq.1 uc009ddq.2 uc009ddq.3 Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan- independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. Interacts with DERL2 and DERL3. Binds to SEL1L (By similarity). Interacts with DNAJC10. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Belongs to the glycosyl hydrolase 47 family. catalytic activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity calcium ion binding protein binding endoplasmic reticulum endoplasmic reticulum membrane response to unfolded protein membrane integral component of membrane aggresome integral component of endoplasmic reticulum membrane ER-associated ubiquitin-dependent protein catabolic process trimming of terminal mannose on C branch endoplasmic reticulum quality control compartment misfolded protein binding glycoprotein ERAD pathway positive regulation of retrograde protein transport, ER to cytosol mannose trimming involved in glycoprotein ERAD pathway alpha-mannosidase activity uc009ddq.1 uc009ddq.2 uc009ddq.3 
ENSMUST00000089165.9 Gm5168 ENSMUST00000089165.9 predicted gene 5168 (from RefSeq NM_001025607.4) EG382275 ENSMUST00000089165.1 ENSMUST00000089165.2 ENSMUST00000089165.3 ENSMUST00000089165.4 ENSMUST00000089165.5 ENSMUST00000089165.6 ENSMUST00000089165.7 ENSMUST00000089165.8 Gm5168 NM_001025607 Q4KL04 Q4KL04_MOUSE uc009svi.1 uc009svi.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc009svi.1 uc009svi.2 
ENSMUST00000089174.6 Ccdc134 ENSMUST00000089174.6 coiled-coil domain containing 134, transcript variant 1 (from RefSeq NM_172428.2) CC134_MOUSE ENSMUST00000089174.1 ENSMUST00000089174.2 ENSMUST00000089174.3 ENSMUST00000089174.4 ENSMUST00000089174.5 NM_172428 Q3U3V9 Q8C7V8 uc007wye.1 uc007wye.2 uc007wye.3 In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling. Has a critical role in the regulation of osteogenesis and bone development. In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF- mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. Interacts with TADA2A. Associates with the PCAF complex via TADA2A binding. Nucleus Cytoplasm Secreted Endoplasmic reticulum Note=Accumulates in the nucleus in response to UV irradiation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C7V8-1; Sequence=Displayed; Name=2; IsoId=Q8C7V8-2; Sequence=VSP_021181; O-glycosylated, with additional sialic acid modifications. Belongs to the CCDC134 family. molecular_function extracellular region nucleus cytoplasm endoplasmic reticulum biological_process uc007wye.1 uc007wye.2 uc007wye.3 
ENSMUST00000089184.11 Kcnj12 ENSMUST00000089184.11 potassium inwardly-rectifying channel, subfamily J, member 12, transcript variant 2 (from RefSeq NM_001267593.1) ENSMUST00000089184.1 ENSMUST00000089184.10 ENSMUST00000089184.2 ENSMUST00000089184.3 ENSMUST00000089184.4 ENSMUST00000089184.5 ENSMUST00000089184.6 ENSMUST00000089184.7 ENSMUST00000089184.8 ENSMUST00000089184.9 Irk2 KCJ12_MOUSE NM_001267593 P52187 Q8CCR0 Q9QYF2 uc033fwc.1 uc033fwc.2 uc033fwc.3 Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Homotetramer. Forms heteromer with KCNJ4. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity). Membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Highest level in cerebellum. Phosphatidylinositol 4,5-bisphosphate binding to the cytoplasmic side of the channel triggers a conformation change leading to channel opening. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily. inward rectifier potassium channel activity voltage-gated ion channel activity plasma membrane ion transport potassium ion transport membrane integral component of membrane PDZ domain binding T-tubule dendrite intrinsic component of membrane regulation of ion transmembrane transport neuronal cell body protein homotetramerization potassium ion import across plasma membrane uc033fwc.1 uc033fwc.2 uc033fwc.3 
ENSMUST00000089185.6 Zdhhc14 ENSMUST00000089185.6 zinc finger, DHHC domain containing 14 (from RefSeq NM_146073.3) ENSMUST00000089185.1 ENSMUST00000089185.2 ENSMUST00000089185.3 ENSMUST00000089185.4 ENSMUST00000089185.5 NM_146073 Q8BNR2 Q8BQQ1 Q8CFN0 ZDH14_MOUSE Zdhhc14 uc008aff.1 uc008aff.2 uc008aff.3 Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and thereby regulate G protein-coupled receptor signaling. May play a role in cell differentiation and apoptosis. Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BQQ1-1; Sequence=Displayed; Name=2; IsoId=Q8BQQ1-2; Sequence=VSP_016272; The DHHC domain is required for palmitoyltransferase activity. Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. Sequence=BAC38040.1; Type=Frameshift; Evidence=; endoplasmic reticulum Golgi apparatus protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity uc008aff.1 uc008aff.2 uc008aff.3 
ENSMUST00000089188.9 Agtr2 ENSMUST00000089188.9 angiotensin II receptor, type 2 (from RefSeq NM_007429.5) AGTR2_MOUSE Agtr2 ENSMUST00000089188.1 ENSMUST00000089188.2 ENSMUST00000089188.3 ENSMUST00000089188.4 ENSMUST00000089188.5 ENSMUST00000089188.6 ENSMUST00000089188.7 ENSMUST00000089188.8 NM_007429 P35374 uc009suq.1 uc009suq.2 uc009suq.3 uc009suq.4 uc009suq.5 Receptor for angiotensin II, a vasoconstricting peptide (PubMed:8726696). Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways (By similarity). Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15539617). Interacts with MTUS1. Cell membrane ; Multi-pass membrane protein Expressed at highest levels in adrenal gland and uterus. Helix VIII may act as a gatekeeper for either suppression or activation of the receptor, depending on post-translational modifications and interactions with various receptor partners. Helix VIII is found in a non-canonical position, stabilizing the active-like state, but at the same time preventing the recruitment of G-proteins or beta-arrestins. Upon switching to a membrane-bound conformation, helix VIII can support the recruitment of G proteins and beta-arrestins. Belongs to the G-protein coupled receptor 1 family. Sequence=AAB49539.1; Type=Erroneous initiation; Evidence=; kidney development regulation of systemic arterial blood pressure by circulatory renin-angiotensin renin-angiotensin regulation of aldosterone production angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure brain renin-angiotensin system G-protein coupled receptor activity angiotensin type II receptor activity plasma membrane cellular sodium ion homeostasis inflammatory response signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger transcription factor binding positive regulation of cell proliferation response to organonitrogen compound negative regulation of heart rate negative regulation of norepinephrine secretion membrane integral component of membrane cerebellar cortex development negative regulation of icosanoid secretion positive regulation of phosphoprotein phosphatase activity intracellular signal transduction regulation of metanephros size exploration behavior positive regulation of renal sodium excretion aldosterone secretion angiotensin-activated signaling pathway regulation of protein import into nucleus vasodilation dopamine biosynthetic process regulation of apoptotic process positive regulation of transcription, DNA-templated negative regulation of fibroblast proliferation perinuclear region of cytoplasm positive regulation of cytokine secretion positive regulation of nitric-oxide synthase activity negative regulation of neurotrophin TRK receptor signaling pathway kidney morphogenesis cell growth involved in cardiac muscle cell development cellular response to dexamethasone stimulus positive regulation of metanephric glomerulus development positive regulation of branching involved in ureteric bud morphogenesis regulation of blood vessel diameter positive regulation of extrinsic apoptotic signaling pathway uc009suq.1 uc009suq.2 uc009suq.3 uc009suq.4 uc009suq.5 
ENSMUST00000089200.3 Cst7 ENSMUST00000089200.3 cystatin F (leukocystatin) (from RefSeq NM_009977.3) CYTF_MOUSE ENSMUST00000089200.1 ENSMUST00000089200.2 NM_009977 O89098 uc008muc.1 uc008muc.2 uc008muc.3 Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system. Secreted Belongs to the cystatin family. cysteine-type endopeptidase inhibitor activity extracellular region extracellular space cytoplasm lysosome endosome late endosome multivesicular body endoplasmic reticulum Golgi apparatus negative regulation of peptidase activity peptidase inhibitor activity cytoplasmic vesicle positive regulation of myelination protein homodimerization activity inhibition of cysteine-type endopeptidase activity negative regulation of microglial cell activation uc008muc.1 uc008muc.2 uc008muc.3 
ENSMUST00000089207.13 Zfp120 ENSMUST00000089207.13 zinc finger protein 120, transcript variant 1 (from RefSeq NM_181266.2) ENSMUST00000089207.1 ENSMUST00000089207.10 ENSMUST00000089207.11 ENSMUST00000089207.12 ENSMUST00000089207.2 ENSMUST00000089207.3 ENSMUST00000089207.4 ENSMUST00000089207.5 ENSMUST00000089207.6 ENSMUST00000089207.7 ENSMUST00000089207.8 ENSMUST00000089207.9 NM_181266 Q78JR8 Q8BZW4 Q9EQK4 Q9JIB8 ZN120_MOUSE Zfp120 uc008mtx.1 uc008mtx.2 uc008mtx.3 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8BZW4-1; Sequence=Displayed; Name=2 ; IsoId=Q8BZW4-2; Sequence=VSP_053088; Widely expressed with highest levels in kidney, brain, and liver, and the lowest levels in spleen. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAF79951.1; Type=Frameshift; Evidence=; Sequence=AAG43564.1; Type=Erroneous initiation; Evidence=; Sequence=AAH13500.2; Type=Erroneous initiation; Evidence=; Sequence=EDL28560.1; Type=Erroneous gene model prediction; Evidence=; molecular_function nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding cellular_component nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc008mtx.1 uc008mtx.2 uc008mtx.3 
ENSMUST00000089215.12 Cntn6 ENSMUST00000089215.12 contactin 6, transcript variant 16 (from RefSeq NR_177191.1) CNTN6_MOUSE ENSMUST00000089215.1 ENSMUST00000089215.10 ENSMUST00000089215.11 ENSMUST00000089215.2 ENSMUST00000089215.3 ENSMUST00000089215.4 ENSMUST00000089215.5 ENSMUST00000089215.6 ENSMUST00000089215.7 ENSMUST00000089215.8 ENSMUST00000089215.9 NR_177191 Q8C6X1 Q9JMB8 uc009dco.1 uc009dco.2 uc009dco.3 uc009dco.4 Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus (By similarity). Involved in motor coordination. Interacts with PTPRG. Q9JMB8; P70232: Chl1; NbExp=5; IntAct=EBI-7703151, EBI-7703109; Cell membrane ; Lipid-anchor, GPI- anchor Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JMB8-1; Sequence=Displayed; Name=2; IsoId=Q9JMB8-2; Sequence=VSP_011968; Expressed in brain. In brain, it is preferentially expressed in the accessory olfactory bulb, layers II/III and V of the cerebral cortex, piriform cortex, anterior thalamic nuclei, locus coeruleus of the pons and mesencephalic trigeminal nucleus and in Purkinje cells of the cerebellum. Highly expressed after birth, reaching a maximum at the postnatal day 7, and declines thereafter in the cerebrum, whereas it increases in the cerebellum to adulthood. Mice are viable and fertile, the formation and organization of all nuclei and layers throughout the brains are apparently normal. They are however slow to learn to stay on the rotating rod in the rotorod test during repeated trials, and display dysfunction of equilibrium and vestibular senses in the wire hang and horizontal rod-walking tests. Belongs to the immunoglobulin superfamily. Contactin family. Notch binding protein binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules Notch signaling pathway nervous system development axon guidance membrane neurogenesis neuron differentiation axon anchored component of membrane positive regulation of Notch signaling pathway dendrite self-avoidance protein binding involved in cell-cell adhesion anchored component of presynaptic membrane uc009dco.1 uc009dco.2 uc009dco.3 uc009dco.4 
ENSMUST00000089217.11 Uba1 ENSMUST00000089217.11 ubiquitin-like modifier activating enzyme 1, transcript variant 1 (from RefSeq NM_009457.5) A6H6S6 ENSMUST00000089217.1 ENSMUST00000089217.10 ENSMUST00000089217.2 ENSMUST00000089217.3 ENSMUST00000089217.4 ENSMUST00000089217.5 ENSMUST00000089217.6 ENSMUST00000089217.7 ENSMUST00000089217.8 ENSMUST00000089217.9 NM_009457 P31253 Q02053 Q542H8 Sbx UBA1_MOUSE Ube1 Ube1ax Ube1x uc292nkp.1 uc292nkp.2 This gene encodes a member of the ubiquitin-activating E1 family. The encoded protein initiates the ubiquitin activation and transfer cascade, catalyzing the first step in ubiquitin conjugation to mark cellular proteins for proteasome degradation. Ubiquitin activating enzymes use ATP to form a thioester between a conserved catalytic cysteine of the enzyme and the C-terminal carboxylate of ubiquitin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1511901). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. Reaction=ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]- L-cysteine.; EC=6.2.1.45; Evidence=; Protein modification; protein ubiquitination. Monomer. Interacts with GAN (via BTB domain). Cytoplasm Mitochondrion Nucleus Ubiquitously expressed. In testis, expressed in A spermatogonia and spermatids but at very low levels in pachytene spermatocytes. In testis, highly expressed from 14.5 days post coitum (dpc) until the day of birth, with levels falling after 10 days post partum (dpp) but peaking again at 28 dpp. May be modulated by the thyroid hormone receptor. ISGylated. There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site. Belongs to the ubiquitin-activating E1 family. Sequence=CAA44465.1; Type=Frameshift; Evidence=; nucleotide binding heterochromatin ubiquitin activating enzyme activity protein binding ATP binding nucleus nucleoplasm cytoplasm mitochondrion lysosomal membrane cytosol cellular protein modification process ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus small protein activating enzyme activity endosome membrane protein ubiquitination ligase activity desmosome rough endoplasmic reticulum membrane protein modification by small protein conjugation uc292nkp.1 uc292nkp.2 
ENSMUST00000089230.7 Ppp2r2a ENSMUST00000089230.7 protein phosphatase 2, regulatory subunit B, alpha, transcript variant 1 (from RefSeq NM_028032.3) 2ABA_MOUSE ENSMUST00000089230.1 ENSMUST00000089230.2 ENSMUST00000089230.3 ENSMUST00000089230.4 ENSMUST00000089230.5 ENSMUST00000089230.6 NM_028032 Q6P1F6 uc007uku.1 uc007uku.2 uc007uku.3 uc007uku.4 uc007uku.5 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with TP53 (By similarity). Interacts with IER5 (By similarity). Interacts with MFHAS1; the interaction is direct (By similarity). Interacts with PABIR1/FAM122A (By similarity). Interacts with CRTC3 (PubMed:30611118). Belongs to the phosphatase 2A regulatory subunit B family. protein phosphatase type 2A complex mitotic cell cycle protein serine/threonine phosphatase activity cytosol protein dephosphorylation protein phosphatase regulator activity response to morphine regulation of phosphoprotein phosphatase activity macromolecular complex binding synapse tau protein binding protein phosphatase 2A binding peptidyl-serine dephosphorylation glutamatergic synapse uc007uku.1 uc007uku.2 uc007uku.3 uc007uku.4 uc007uku.5 
ENSMUST00000089236.11 Pnma2 ENSMUST00000089236.11 paraneoplastic antigen MA2 (from RefSeq NM_175498.4) ENSMUST00000089236.1 ENSMUST00000089236.10 ENSMUST00000089236.2 ENSMUST00000089236.3 ENSMUST00000089236.4 ENSMUST00000089236.5 ENSMUST00000089236.6 ENSMUST00000089236.7 ENSMUST00000089236.8 ENSMUST00000089236.9 NM_175498 PNMA2_MOUSE Q8BHK0 uc007ukq.1 uc007ukq.2 uc007ukq.3 uc007ukq.4 Nucleus, nucleolus Expressed in the cerebrum, cerebellum and testis. Belongs to the PNMA family. molecular_function cellular_component nucleus nucleolus biological_process uc007ukq.1 uc007ukq.2 uc007ukq.3 uc007ukq.4 
ENSMUST00000089246.6 Tex13c3 ENSMUST00000089246.6 TEX13 family member C3 (from RefSeq NM_207524.4) BC049702 ENSMUST00000089246.1 ENSMUST00000089246.2 ENSMUST00000089246.3 ENSMUST00000089246.4 ENSMUST00000089246.5 NM_207524 Q810P0 Q810P0_MOUSE Tex13c3 uc292njq.1 uc292njq.2 Belongs to the TEX13 family. molecular_function cellular_component biological_process uc292njq.1 uc292njq.2 
ENSMUST00000089257.6 Insm1 ENSMUST00000089257.6 insulinoma-associated 1 (from RefSeq NM_016889.4) ENSMUST00000089257.1 ENSMUST00000089257.2 ENSMUST00000089257.3 ENSMUST00000089257.4 ENSMUST00000089257.5 INSM1_MOUSE Ia1 NM_016889 Q63ZV0 Q9Z113 uc008msh.1 uc008msh.2 uc008msh.3 uc008msh.4 uc008msh.5 Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle- independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (By similarity). Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation. Interacts (via the N-terminal region) with CCND1 (via cyclin N-terminal domain); the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and increases its transcriptional repressor activity. Interacts with HDAC3; the interaction increases its transcriptional repressor activity (By similarity). Interacts (via the SNAG domain) with HDAC1. Interacts (via the SNAG domain) with HDAC2. Interacts (via the SNAG domain) with KDM1A. Interacts (via the SNAG domain) with RCOR1. Interacts with SORBS1. Nucleus Expressed in adrenal gland. Expressed in the dentate gyrus of the hippocampus and the wall of the lateral ventricle. Expressed in pancreatic and intestinal endocrine cells. Expressed in differentiating endocrine cells of the anterior pituitary gland between 11.5 and 17.5 dpc. Expressed in all hormone-secreting cell types of the pituitary gland. Expressed in primary sympathetic ganglion chain, spinal cord and in neurons of the dorsal root ganglia at 9.5 dpc. Expressed in chromaffin cells of the adrenal medulla at 13.5 dpc (at protein level). Expressed in the developing central nervous system (CNS). Expressed in midbrain- hindbrain region at 9.5 dpc, in the spinal cord and telencephalon at 11 dpc. Expressed in the forebrain, midbrain, hind brain, spinal cord, cerebellum, olfactory bulb and retina between 11.5 and 14.5 dpc. Expressed in neural stem and progenitor cells of the developing neocortex in both the ventricular zone (VZ) and in the adjacent subventricular zone (SVZ), and in the external granule cell layer of the developing cerebellum between 11 and 16.5 dpc. Expressed in neural progenitor cells at the apical side of the VZ, collectively referred to as apical basal cells (APs; neuroepithelial cells, radial glial cells and short neural precursors) between 10.5 and 16.5 dpc. Expressed in neural progenitor cells in the basal region of the VZ between 10.5 and 16.5 dpc and at later stages in basal progenitor cells (BPs) of the SVZ. Expressed in the cerebellum and pineal gland at 18.5 dpc. Expressed in islet progenitor cells at 10.5 dpc. Expressed in endocrine pancreatic cells, enteric nervous system, duodenum, stomach, thymus, thyroid, adrenal glands at 15.5 dpc. The C-terminal region is necessary for NEUROD1 promoter DNA- binding and transcriptional repressor activity. Mice die during the second half of gestation; lethality is caused by heart failure due to insufficient catecholamine synthesis. Display pancreatic, intestinal and sympatho-adrenal endocrine cell development impairment. Exhibits fewer terminally dividing neuronogenic basal progenitor cells (BPs) in the neocortex. Belongs to the INSM1 family. Sequence=AAD15718.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding negative regulation of protein phosphorylation type B pancreatic cell differentiation pancreatic A cell differentiation type B pancreatic cell development noradrenergic neuron development nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytosol cell cycle multicellular organism development nervous system development positive regulation of cell proliferation negative regulation of cell proliferation regulation of gene expression regulation of cell cycle process transcriptional repressor complex cell differentiation neuron differentiation cyclin binding positive regulation of cell migration endocrine pancreas development chromatin DNA binding endocrine system development norepinephrine biosynthetic process histone deacetylase binding regulation of protein complex assembly positive regulation of cell differentiation metal ion binding transdifferentiation adrenal chromaffin cell differentiation sympathetic ganglion development positive regulation of cell cycle arrest positive regulation of neural precursor cell proliferation uc008msh.1 uc008msh.2 uc008msh.3 uc008msh.4 uc008msh.5 
ENSMUST00000089287.7 Uba3 ENSMUST00000089287.7 ubiquitin-like modifier activating enzyme 3, transcript variant 1 (from RefSeq NM_011666.3) ENSMUST00000089287.1 ENSMUST00000089287.2 ENSMUST00000089287.3 ENSMUST00000089287.4 ENSMUST00000089287.5 ENSMUST00000089287.6 NM_011666 O88598 Q3TG68 Q8C878 Q9D6B7 UBA3_MOUSE Ube1c uc009dam.1 uc009dam.2 uc009dam.3 uc009dam.4 uc009dam.5 The protein encoded by this gene is the catalytic subunit of the enzyme that activates NEDD8, a ubiquitin-like molecule that binds to its target proteins through an enzymatic reaction analagous to ubiquitylation. Embryonic mice deficient for this protein die prior to implantation and display apoptosis of the inner cell mass. Trophoblastic cells cannot enter S phase, demonstrating that this gene is required for cell cycle progression during embryogenesis. Two pseudogenes have been found for this gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression. [NEDD8-activating enzyme E1 catalytic subunit]: Reaction=ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L- cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.; EC=6.2.1.64; Evidence=; Binding of TP53BP2 to the regulatory subunit NAE1 decreases activity. Protein modification; protein neddylation. Heterodimer of UBA3 and NAE1. Interacts with NEDD8, UBE2F and UBE2M. Binds ESR1 and ESR2 with bound steroid ligand (By similarity). Interacts with TBATA. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C878-1; Sequence=Displayed; Name=2; IsoId=Q8C878-2; Sequence=VSP_010787; Note=Defects in Uba3 are a cause of embryonic lethality. Mouse embryos deficient in Uba3 die at the preimplantation stage (PubMed:11696557). Arg-211 acts as a selectivity gate, preventing misactivation of ubiquitin by this NEDD8-specific E1 complex. Belongs to the ubiquitin-activating E1 family. UBA3 subfamily. nucleotide binding mitotic cell cycle protein binding ATP binding nucleus cytoplasm cell cycle endomitotic cell cycle small protein activating enzyme activity ligase activity ligand-dependent nuclear receptor binding NEDD8 activating enzyme activity protein modification by small protein conjugation macromolecular complex identical protein binding protein neddylation negative regulation of transcription, DNA-templated protein heterodimerization activity regulation of cell cycle uc009dam.1 uc009dam.2 uc009dam.3 uc009dam.4 uc009dam.5 
ENSMUST00000089289.6 Arl13b ENSMUST00000089289.6 ADP-ribosylation factor-like 13B (from RefSeq NM_026577.4) AR13B_MOUSE Arl2l1 ENSMUST00000089289.1 ENSMUST00000089289.2 ENSMUST00000089289.3 ENSMUST00000089289.4 ENSMUST00000089289.5 G3X9K5 NM_026577 Q640N2 uc007zpu.1 uc007zpu.2 uc007zpu.3 uc007zpu.4 Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling (PubMed:23817546). Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex (PubMed:23153492). Monomer. Interacts with IFT complex B components IFT46 and IFT74 (By similarity). Interacts with CIMAP3 (By similarity) (PubMed:20643351). Interacts with EXOC2; regulates ARL13B localization to the cilium membrane (PubMed:26582389). Cell projection, cilium membrane ipid-anchor ll projection, cilium Note=Associates to the cilium membrane via palmitoylation. Localizes to proximal ciliary membranes, to an inversin-like subciliary membrane compartment, excluding the transition zone. Cilium-specific protein. Expressed in neuroepithelial cells and developing radial glia of the developing cerebral cortex: present in both neuroepithelial and radial progenitor cells. In radial progenitors, found in the apical, cell soma domains of these cells (at protein level). Expressed in the primary cilia of postmitotic cortical neurons during embryonic and postnatal development. Sumoylation is required for PKD2 entry into cilium. Impaired cilium's ability to convey critical extracellular signals such as Shh, without destroying cilia and their downstream pathways. Mice show a constitutive low-level of Shh activity owing to loss of modulation of Gli2 activator, corresponding to the specification of progenitors of motoneurons through most of the neural tube. In contrast to other mouse mutants that disrupt cilia, Gli3 repressor activity is unaffected in mutants (PubMed:17488627). Mutants show abnormal cilia in which components of Shh signaling are not regulated properly: Ptch1 and Smo localize to cilia regardless of Shh stimulation, and there is no Gli enrichment in cilia upon Shh stimulation (PubMed:21976698). Conditional deletion disrupts interneuronal placement, but not postmigratory differentiation in the developing cerebral cortex (PubMed:23153492). Early neuroepithelial- specific deletion in cortical progenitors induces a reversal of the apical-basal polarity of radial progenitors and aberrant neuronal placement (PubMed:23817546). Used as a ciliary marker because of its specific localization to microtubule doublets of the ciliary axoneme. Frequently used to study cilium signaling, since in contrast to most cilia null mutants, deletion of Arl13b impairs without destroying cilia and their downstream pathways (PubMed:23817546). Belongs to the small GTPase superfamily. Arf family. nucleotide binding heart looping GTP binding plasma membrane cilium axoneme smoothened signaling pathway multicellular organism development determination of left/right symmetry dorsal/ventral pattern formation response to lithium ion membrane neural tube patterning interneuron migration from the subpallium to the cortex formation of radial glial scaffolds motile cilium cell projection ciliary membrane cilium assembly left/right axis specification receptor localization to non-motile cilium non-motile cilium non-motile cilium assembly uc007zpu.1 uc007zpu.2 uc007zpu.3 uc007zpu.4 
ENSMUST00000089293.11 Cbx7 ENSMUST00000089293.11 Cbx7 (from geneSymbol) AK045714 Cbx7 ENSMUST00000089293.1 ENSMUST00000089293.10 ENSMUST00000089293.2 ENSMUST00000089293.3 ENSMUST00000089293.4 ENSMUST00000089293.5 ENSMUST00000089293.6 ENSMUST00000089293.7 ENSMUST00000089293.8 ENSMUST00000089293.9 F8WHN2 F8WHN2_MOUSE uc007wuw.1 uc007wuw.2 uc007wuw.3 nucleus uc007wuw.1 uc007wuw.2 uc007wuw.3 
ENSMUST00000089295.6 Tafa4 ENSMUST00000089295.6 TAFA chemokine like family member 4 (from RefSeq NM_177233.5) ENSMUST00000089295.1 ENSMUST00000089295.2 ENSMUST00000089295.3 ENSMUST00000089295.4 ENSMUST00000089295.5 Fam19a4 NM_177233 Q5FWC0 Q7TPG5 Q8BV02 TAFA4_MOUSE uc009dah.1 uc009dah.2 uc009dah.3 Modulates injury-induced and chemical pain hypersensitivity (PubMed:24139797). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release (PubMed:25109685). Secreted Expressed in a descrete subset of dorsal root ganglia neurons called C-low-threshold mechanoreceptors (at protein level) (PubMed:24139797). Expressed in LPS-stimulated monocytes and macrophages, especially in polarized M1 (PubMed:25109685). Up-regulated in LPS-stimulated monocytes and macrophages, especially in polarized M1. Mutant mice exhibit enhanced mechanical and chemical hypersensitivity following inflammation and nerve injury. Belongs to the TAFA family. Sequence=BAC38247.1; Type=Frameshift; Evidence=; extracellular region extracellular space phagocytosis signal transduction regulation of receptor activity regulation of membrane potential superoxide anion generation receptor agonist activity macrophage chemotaxis regulation of sensory perception of pain uc009dah.1 uc009dah.2 uc009dah.3 
ENSMUST00000089296.3 Or52n4 ENSMUST00000089296.3 olfactory receptor family 52 subfamily N member 4 (from RefSeq NM_147049.4) ENSMUST00000089296.1 ENSMUST00000089296.2 NM_147049 Olfr658 Or52n4 Q8VGV5 Q8VGV5_MOUSE uc009iwt.1 uc009iwt.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AK033992.1, BB625862.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164133, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009iwt.1 uc009iwt.2 
ENSMUST00000089302.11 Usp9x ENSMUST00000089302.11 ubiquitin specific peptidase 9, X chromosome, transcript variant 1 (from RefSeq NM_009481.3) ENSMUST00000089302.1 ENSMUST00000089302.10 ENSMUST00000089302.2 ENSMUST00000089302.3 ENSMUST00000089302.4 ENSMUST00000089302.5 ENSMUST00000089302.6 ENSMUST00000089302.7 ENSMUST00000089302.8 ENSMUST00000089302.9 NM_009481 Q4FE56 Q4FE56_MOUSE Usp9x uc009sri.1 uc009sri.2 uc009sri.3 uc009sri.4 Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; neuron migration cytoplasm cytosol proteolysis ubiquitin-dependent protein catabolic process transforming growth factor beta receptor signaling pathway peptidase activity protein deubiquitination growth cone BMP signaling pathway thiol-dependent ubiquitinyl hydrolase activity regulation of circadian rhythm axon extension protein stabilization co-SMAD binding protein K48-linked deubiquitination protein deubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of DNA demethylation Lys48-specific deubiquitinase activity uc009sri.1 uc009sri.2 uc009sri.3 uc009sri.4 
ENSMUST00000089318.5 Gpr15 ENSMUST00000089318.5 G protein-coupled receptor 15 (from RefSeq NM_001162955.2) E9QKY6 ENSMUST00000089318.1 ENSMUST00000089318.2 ENSMUST00000089318.3 ENSMUST00000089318.4 GPR15_MOUSE NM_001162955 Q0VDU3 Q3B800 uc007zob.1 uc007zob.2 uc007zob.3 Probable chemokine receptor. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. virus receptor activity G-protein coupled receptor activity cytoplasm endosome plasma membrane signal transduction G-protein coupled receptor signaling pathway coreceptor activity membrane integral component of membrane viral entry into host cell T cell migration uc007zob.1 uc007zob.2 uc007zob.3 
ENSMUST00000089332.5 Col8a1 ENSMUST00000089332.5 collagen, type VIII, alpha 1 (from RefSeq NM_007739.2) B8JJL9 CO8A1_MOUSE ENSMUST00000089332.1 ENSMUST00000089332.2 ENSMUST00000089332.3 ENSMUST00000089332.4 NM_007739 Q00780 Q3TWU7 Q8BGL6 Q921S8 Q9D2V4 uc007znl.1 uc007znl.2 uc007znl.3 Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis. Homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrahedron stabilized by central interacting C-terminal NC1 trimers (By similarity). Secreted, extracellular space, extracellular matrix, basement membrane. High levels in calvarium, eye and skin of newborn mice; also in various epithelial, endothelial and mesenchymal cells. Up-regulated in astrocytes during the repair process and in mesangial cells in diabetic animals. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Proteolytically cleaved by neutrophil elastase, in vitro. Proteolytic processing produces the C-terminal NC1 domain fragment, vastatin (By similarity). COL8A1(-)/COL8A2(-) mice exhibit decreased proliferation of measngial cells, reduced phosphorylation of ERK1/2 and increased p27(KIP1) expression. Diabetic COL8A1(-)/COL8A2(-) mice reveal reduced mesangial expansion and cellularity and extracellular matrix expansion. angiogenesis extracellular matrix structural constituent extracellular region collagen trimer basement membrane extracellular space cell adhesion positive regulation of cell-substrate adhesion extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix endodermal cell differentiation camera-type eye morphogenesis epithelial cell proliferation uc007znl.1 uc007znl.2 uc007znl.3 
ENSMUST00000089338.6 Prss55 ENSMUST00000089338.6 serine protease 55, transcript variant 4 (from RefSeq NR_166743.1) ENSMUST00000089338.1 ENSMUST00000089338.2 ENSMUST00000089338.3 ENSMUST00000089338.4 ENSMUST00000089338.5 G3X9K6 NR_166743 PRS55_MOUSE Q14BX2 uc007uib.1 uc007uib.2 uc007uib.3 Probable serine protease, which plays a crucial role in the fertility of male mice including sperm migration and sperm-egg interaction (PubMed:30032357). Cell membrane ; Lipid-anchor, GPI-anchor Cytoplasmic vesicle, secretory vesicle, acrosome Note=Mainly observed in the luminal side of seminiferous tubules and sperm acrosome. Expressed in adult mouse testis. Deficient male display infertility with impaired sperm migration from uterus into oviduct and defective sperm-zona and sperm-egg recognition/binding. However, the mating activity, sperm production, sperm morphology, sperm motility, inducibility of AR, activity of acrosomal enzymes and in vitro sperm fertility are almost normal. Male show an absence of mature ADAM3 in sperm. Belongs to the peptidase S1 family. Controversial data exist concerning the topology of PRS55. One study in mouse shows that PRSS55 is a GPI-anchored protein (PubMed:30032357). An other study does not confirm the GPI-anchor status of PRSS55 (By similarity). However, as a GPI-anchor motif is detected, the possibility of a GPI-anchor instead of a single-pass type I membrane protein is probable. serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc007uib.1 uc007uib.2 uc007uib.3 
ENSMUST00000089362.9 Senp7 ENSMUST00000089362.9 SUMO1/sentrin specific peptidase 7, transcript variant 1 (from RefSeq NM_025483.4) ENSMUST00000089362.1 ENSMUST00000089362.2 ENSMUST00000089362.3 ENSMUST00000089362.4 ENSMUST00000089362.5 ENSMUST00000089362.6 ENSMUST00000089362.7 ENSMUST00000089362.8 Kiaa1707 NM_025483 Q6P398 Q80TA3 Q8BUH8 SENP7_MOUSE Senp7 Susp2 uc007zmi.1 uc007zmi.2 uc007zmi.3 uc007zmi.4 This gene encodes a SUMO deconjugating enzyme of the Sentrin/SUMO-specific protease (SENP) family. The encoded protein is a protease that exhibits deSUMOylating activity towards proteins involved in chromatin remodeling and promotes chromatin relaxation for DNA repair or transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS (PubMed:28095500). Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (PubMed:28095500). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (By similarity). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (By similarity). Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity). Q8BUH8; Q61686: Cbx5; NbExp=4; IntAct=EBI-15972382, EBI-307973; Cytoplasm Belongs to the peptidase C48 family. Sequence=BAC65824.1; Type=Erroneous initiation; Evidence=; protein binding nucleus cytoplasm proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity protein desumoylation SUMO-specific endopeptidase activity uc007zmi.1 uc007zmi.2 uc007zmi.3 uc007zmi.4 
ENSMUST00000089370.6 Ssxb5 ENSMUST00000089370.6 SSX member B5 (from RefSeq NM_199319.3) ENSMUST00000089370.1 ENSMUST00000089370.2 ENSMUST00000089370.3 ENSMUST00000089370.4 ENSMUST00000089370.5 NM_199319 Q6XAS2 Q6XAS2_MOUSE Ssxb5 uc009spg.1 uc009spg.2 Belongs to the SSX family. nucleic acid binding nucleus regulation of transcription, DNA-templated uc009spg.1 uc009spg.2 
ENSMUST00000089374.11 Ssxb3 ENSMUST00000089374.11 SSX member B3 (from RefSeq NM_198898.3) ENSMUST00000089374.1 ENSMUST00000089374.10 ENSMUST00000089374.2 ENSMUST00000089374.3 ENSMUST00000089374.4 ENSMUST00000089374.5 ENSMUST00000089374.6 ENSMUST00000089374.7 ENSMUST00000089374.8 ENSMUST00000089374.9 NM_198898 Q6XAS4 Q6XAS4_MOUSE Ssxb3 uc009spd.1 uc009spd.2 uc009spd.3 Belongs to the SSX family. nucleic acid binding nucleus regulation of transcription, DNA-templated uc009spd.1 uc009spd.2 uc009spd.3 
ENSMUST00000089377.6 Lgals1 ENSMUST00000089377.6 lectin, galactose binding, soluble 1 (from RefSeq NM_008495.2) ENSMUST00000089377.1 ENSMUST00000089377.2 ENSMUST00000089377.3 ENSMUST00000089377.4 ENSMUST00000089377.5 Gbp LEG1_MOUSE NM_008495 P05163 P11946 P16045 P17601 Q4FZH4 Q99M27 Q9D0X0 uc007wrv.1 uc007wrv.2 Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45. Interacts with laminin (via poly-N- acetyllactosamine). Interacts with SUSD2. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Secreted, extracellular space, extracellular matrix Cytoplasm Secreted Note=Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. Was originally thought to originate from human. Sequence=AAA37313.1; Type=Frameshift; Evidence=; Sequence=AK004298; Type=Frameshift; Evidence=; plasma cell differentiation protein binding galactose binding extracellular region extracellular space nucleus cytoplasm cytosol apoptotic process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell surface negative regulation of cell-substrate adhesion negative regulation of neuron projection development carbohydrate binding lactose binding T cell costimulation positive regulation of erythrocyte aggregation response to isolation stress response to drug protein homodimerization activity laminin binding myoblast differentiation positive regulation of viral entry into host cell response to axon injury cellular response to glucose stimulus cellular response to organic cyclic compound maintenance of protein location uc007wrv.1 uc007wrv.2 
ENSMUST00000089378.5 Pdxp ENSMUST00000089378.5 pyridoxal (pyridoxine, vitamin B6) phosphatase (from RefSeq NM_020271.3) Cin ENSMUST00000089378.1 ENSMUST00000089378.2 ENSMUST00000089378.3 ENSMUST00000089378.4 NM_020271 P60487 PLPP_MOUSE Pdxp Plp Plpp uc007wru.1 uc007wru.2 Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism (PubMed:24338473, PubMed:24338687, PubMed:25783190). Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine (By similarity). Reaction=H2O + pyridoxal 5'-phosphate = phosphate + pyridoxal; Xref=Rhea:RHEA:20533, ChEBI:CHEBI:15377, ChEBI:CHEBI:17310, ChEBI:CHEBI:43474, ChEBI:CHEBI:597326; EC=3.1.3.74; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20534; Evidence=; Reaction=H2O + pyridoxine 5'-phosphate = phosphate + pyridoxine; Xref=Rhea:RHEA:25112, ChEBI:CHEBI:15377, ChEBI:CHEBI:16709, ChEBI:CHEBI:43474, ChEBI:CHEBI:58589; EC=3.1.3.74; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25113; Evidence=; Reaction=phosphate + pyridoxamine = H2O + pyridoxamine 5'-phosphate; Xref=Rhea:RHEA:25135, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57761, ChEBI:CHEBI:58451; EC=3.1.3.74; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:25137; Evidence=; Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20630; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Note=Divalent metal ions. Mg(2+) is the most effective. ; Inhibited by beryllium trifluoride. Kinetic parameters: KM=36 uM for pyridoxal 5'-phosphate Vmax=3.6 umol/min/mg enzyme with pyridoxal 5'-phosphate as substrate ; Note=kcat varies between 1.5 and 2.0 sec(-1) for the dephosphorylation of pyridoxal 5'-phosphate (at pH 7.4 and 22 degrees Celsius). ; Homodimer. Cytoplasm, cytosol Cytoplasm, cytoskeleton Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody. Ubiquitous. highly expressed in brain (at protein level). Belongs to the HAD-like hydrolase superfamily. magnesium ion binding phosphoserine phosphatase activity phosphoprotein phosphatase activity protein binding cytoplasm cytosol cytoskeleton plasma membrane cell-cell junction protein dephosphorylation regulation of mitotic nuclear division actin cytoskeleton membrane dephosphorylation hydrolase activity phosphatase activity growth factor binding lamellipodium midbody positive regulation of actin filament depolymerization heat shock protein binding actin rod assembly lamellipodium membrane cleavage furrow pyridoxal phosphate catabolic process regulation of cytokinesis ruffle membrane pyridoxal phosphatase activity protein homodimerization activity cell projection metal ion binding contractile ring cellular response to ATP uc007wru.1 uc007wru.2 
ENSMUST00000089398.9 Il2rb ENSMUST00000089398.9 interleukin 2 receptor, beta chain (from RefSeq NM_008368.4) ENSMUST00000089398.1 ENSMUST00000089398.2 ENSMUST00000089398.3 ENSMUST00000089398.4 ENSMUST00000089398.5 ENSMUST00000089398.6 ENSMUST00000089398.7 ENSMUST00000089398.8 IL2RB_MOUSE NM_008368 P16297 Q3TZT2 uc007wpk.1 uc007wpk.2 uc007wpk.3 uc007wpk.4 uc007wpk.5 The interleukin 2 receptor is composed of alpha and beta subunits. The beta subunit encoded by this gene is very homologous to the human beta subunit and also shows structural similarity to other cytokine receptors. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK017288.1, AK169481.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation (By similarity). Cell membrane ; Single-pass type I membrane protein Cell surface The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Belongs to the type I cytokine receptor family. Type 4 subfamily. cytokine receptor activity interleukin-2 receptor activity plasma membrane external side of plasma membrane cell surface membrane integral component of membrane cytokine-mediated signaling pathway interleukin-2 binding natural killer cell activation interleukin-15-mediated signaling pathway interleukin-2-mediated signaling pathway interleukin-15 receptor activity negative regulation of apoptotic process positive regulation of phagocytosis uc007wpk.1 uc007wpk.2 uc007wpk.3 uc007wpk.4 uc007wpk.5 
ENSMUST00000089430.6 Uba52rt ENSMUST00000089430.6 Cytoplasm Nucleus (from UniProt Q5M9K3) AK018726 ENSMUST00000089430.1 ENSMUST00000089430.2 ENSMUST00000089430.3 ENSMUST00000089430.4 ENSMUST00000089430.5 Q5M9K3 Q5M9K3_MOUSE Uba52 uc290kzt.1 uc290kzt.2 Cytoplasm Nucleus In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family. In the N-terminal section; belongs to the ubiquitin family. structural constituent of ribosome nucleus cytoplasm ribosome translation response to insecticide cytosolic large ribosomal subunit uc290kzt.1 uc290kzt.2 
ENSMUST00000089465.6 Apol10b ENSMUST00000089465.6 apolipoprotein L 10B (from RefSeq NM_177820.4) Apol10b ENSMUST00000089465.1 ENSMUST00000089465.2 ENSMUST00000089465.3 ENSMUST00000089465.4 ENSMUST00000089465.5 G3X9K7 G3X9K7_MOUSE NM_177820 uc007wnu.1 uc007wnu.2 uc007wnu.3 uc007wnu.4 Belongs to the apolipoprotein L family. cellular_component extracellular region lipid transport biological_process lipid binding membrane integral component of membrane lipoprotein metabolic process uc007wnu.1 uc007wnu.2 uc007wnu.3 uc007wnu.4 
ENSMUST00000089469.7 Apol7b ENSMUST00000089469.7 apolipoprotein L 7b (from RefSeq NM_001024848.2) Apol7b B1AQP7 B1AQP7_MOUSE ENSMUST00000089469.1 ENSMUST00000089469.2 ENSMUST00000089469.3 ENSMUST00000089469.4 ENSMUST00000089469.5 ENSMUST00000089469.6 NM_001024848 uc007wnp.1 uc007wnp.2 Belongs to the apolipoprotein L family. cellular_component extracellular region lipid transport lipid binding lipoprotein metabolic process uc007wnp.1 uc007wnp.2 
ENSMUST00000089473.5 Zdhhc20 ENSMUST00000089473.5 zinc finger, DHHC domain containing 20, transcript variant 2 (from RefSeq NM_029492.5) ENSMUST00000089473.1 ENSMUST00000089473.2 ENSMUST00000089473.3 ENSMUST00000089473.4 NM_029492 Q3TDL1 Q5Y5T1 Q8VCL6 Q9D3Q8 ZDH20_MOUSE Zdhhc20 uc007udr.1 uc007udr.2 uc007udr.3 Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:15603741). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains (By similarity). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Reaction=L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S- tetradecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59736, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:15433, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:143199; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59737; Evidence=; Reaction=L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S- octadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59740, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:15434, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:143200; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59741; Evidence=; Golgi apparatus membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region Endoplasmic reticulum membrane ; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5Y5T1-1; Sequence=Displayed; Name=2; IsoId=Q5Y5T1-2; Sequence=VSP_016278; Highest levels in lung. The DHHC domain is required for palmitoyltransferase activity. Autopalmitoylated (in vitro). Belongs to the DHHC palmitoyltransferase family. Golgi membrane cytoplasm endoplasmic reticulum Golgi apparatus plasma membrane protein targeting to membrane zinc ion binding membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity integral component of Golgi membrane metal ion binding perinuclear region of cytoplasm uc007udr.1 uc007udr.2 uc007udr.3 
ENSMUST00000089494.6 Il17d ENSMUST00000089494.6 interleukin 17D (from RefSeq NM_145837.4) A0A0B4J1G4 A0A0B4J1G4_MOUSE ENSMUST00000089494.1 ENSMUST00000089494.2 ENSMUST00000089494.3 ENSMUST00000089494.4 ENSMUST00000089494.5 Il17d NM_145837 uc007udc.1 uc007udc.2 uc007udc.3 Secreted Belongs to the IL-17 family. cytokine activity extracellular region extracellular space inflammatory response signal transduction positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interleukin-6 production positive regulation of interleukin-8 production protein homodimerization activity receptor agonist activity positive regulation of cytokine production involved in inflammatory response negative regulation of hemopoiesis uc007udc.1 uc007udc.2 uc007udc.3 
ENSMUST00000089497.7 Isy1 ENSMUST00000089497.7 ISY1 splicing factor homolog, transcript variant 4 (from RefSeq NR_184548.1) ENSMUST00000089497.1 ENSMUST00000089497.2 ENSMUST00000089497.3 ENSMUST00000089497.4 ENSMUST00000089497.5 ENSMUST00000089497.6 ISY1_MOUSE Kiaa1160 NR_184548 Q69ZQ2 Q8VDX4 Q9D3E2 uc009cub.1 uc009cub.2 uc009cub.3 uc009cub.4 Component of the spliceosome C complex required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation (PubMed:26255770, PubMed:29804889). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (PubMed:26255770). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (PubMed:29804889). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (PubMed:29804889). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes the transition to the primed state (PubMed:29804889). Involved in pre-mRNA splicing as component of the spliceosome. Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19. Interacts with CPSF3; this interaction is in an RNA independent manner (PubMed:26255770). Interacts with the microprocessor complex subunits DGCR8 and DROSHA; this interaction is in an RNA dependent manner (PubMed:26255770). Nucleus During embryoid body (EB) formation, expression peaks at day 1 of EB differentiation (at protein level) (PubMed:29804889). Expressed during embryonic stem cell differentiation in vitro, with high expression during the earliest time point of differentiation during a 'poised' pluripotency phase that occurs in between embryonic day 4.5 and embryonic day 5.5 (PubMed:26255770, PubMed:29804889). Belongs to the ISY1 family. Sequence=BAD32394.1; Type=Erroneous initiation; Evidence=; generation of catalytic spliceosome for second transesterification step mRNA 3'-splice site recognition mRNA splicing, via spliceosome Prp19 complex nucleus spliceosomal complex mRNA processing RNA splicing U2-type catalytic step 1 spliceosome catalytic step 2 spliceosome post-mRNA release spliceosomal complex post-spliceosomal complex first spliceosomal transesterification activity uc009cub.1 uc009cub.2 uc009cub.3 uc009cub.4 
ENSMUST00000089510.5 Cenpb ENSMUST00000089510.5 centromere protein B (from RefSeq NM_007682.4) CENPB_MOUSE Cenp-b ENSMUST00000089510.1 ENSMUST00000089510.2 ENSMUST00000089510.3 ENSMUST00000089510.4 NM_007682 P27790 Q7TSG8 uc008mkx.1 uc008mkx.2 uc008mkx.3 uc008mkx.4 Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes. Antiparallel homodimer. Interacts with CENPT. Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1. Nucleus Chromosome, centromere Poly-ADP-ribosylated by PARP1. N-terminally methylated by METTL11A/NTM1. Alpha-N-methylation is stimulated in response to extracellular stimuli, including increased cell density and heat shock, and seems to facilitate binding to CENP-B boxes. Chromatin-bound CENP-B is primarily trimethylated. chromosome, centromeric region condensed nuclear chromosome, centromeric region nucleic acid binding DNA binding chromatin binding satellite DNA binding nucleus chromosome nuclear body nuclear pericentric heterochromatin uc008mkx.1 uc008mkx.2 uc008mkx.3 uc008mkx.4 
ENSMUST00000089519.13 Aak1 ENSMUST00000089519.13 AP2 associated kinase 1, transcript variant 4 (from RefSeq NM_001378654.1) AAK1_MOUSE B2RUJ0 ENSMUST00000089519.1 ENSMUST00000089519.10 ENSMUST00000089519.11 ENSMUST00000089519.12 ENSMUST00000089519.2 ENSMUST00000089519.3 ENSMUST00000089519.4 ENSMUST00000089519.5 ENSMUST00000089519.6 ENSMUST00000089519.7 ENSMUST00000089519.8 ENSMUST00000089519.9 Kiaa1048 NM_001378654 Q3TY53 Q3UHJ0 Q6ZPZ6 Q80XP6 uc009css.1 uc009css.2 uc009css.3 Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Preferentially, may phosphorylate substrates on threonine residues. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Stimulated by clathrin. Interacts (via CBD domain) with clathrin (By similarity). Interacts with AP-2 complex (By similarity). Interacts with NUMB (By similarity). Interacts with alpha-adaptin (By similarity). Interacts with EPS15 isoform 2 (By similarity). Interacts with membrane-bound activated NOTCH1 but not with the inactive full-length form of NOTCH1 (PubMed:21464124). Preferentially interacts with monoubiquitinated activated NOTCH1 compared to the non-ubiquitinated form (PubMed:21464124). Cell membrane ; Peripheral membrane protein Membrane, clathrin-coated pit Presynapse Note=Active when found in clathrin- coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UHJ0-1; Sequence=Displayed; Name=2; IsoId=Q3UHJ0-2; Sequence=VSP_020670; Autophosphorylated. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity Notch binding ATP binding nucleus plasma membrane clathrin-coated pit protein phosphorylation endocytosis membrane kinase activity phosphorylation transferase activity extrinsic component of plasma membrane clathrin-coated vesicle cell leading edge regulation of protein localization AP-2 adaptor complex binding terminal bouton positive regulation of Notch signaling pathway protein autophosphorylation protein stabilization clathrin complex presynapse regulation of clathrin-dependent endocytosis uc009css.1 uc009css.2 uc009css.3 
ENSMUST00000089534.6 Gm47854 ENSMUST00000089534.6 Gm47854 (from geneSymbol) AK081273 ENSMUST00000089534.1 ENSMUST00000089534.2 ENSMUST00000089534.3 ENSMUST00000089534.4 ENSMUST00000089534.5 uc292hfw.1 uc292hfw.2 uc292hfw.1 uc292hfw.2 
ENSMUST00000089549.8 Gzme ENSMUST00000089549.8 granzyme E (from RefSeq NM_010373.3) Ccp3 Ctla-6 Ctla6 ENSMUST00000089549.1 ENSMUST00000089549.2 ENSMUST00000089549.3 ENSMUST00000089549.4 ENSMUST00000089549.5 ENSMUST00000089549.6 ENSMUST00000089549.7 GRAE_MOUSE NM_010373 P08884 P97389 uc007ubo.1 uc007ubo.2 uc007ubo.3 This enzyme is probably necessary for target cell lysis in cell-mediated immune responses. Cytolytic granule. Belongs to the peptidase S1 family. Granzyme subfamily. serine-type endopeptidase activity cytoplasm proteolysis peptidase activity serine-type peptidase activity granzyme-mediated apoptotic signaling pathway hydrolase activity cytolysis uc007ubo.1 uc007ubo.2 uc007ubo.3 
ENSMUST00000089555.3 Cma2 ENSMUST00000089555.3 chymase 2, mast cell, transcript variant 1 (from RefSeq NM_001024714.3) Cma2 ENSMUST00000089555.1 ENSMUST00000089555.2 Mcp10 NM_001024714 Q91VB1 Q91VB1_MOUSE uc007ubg.1 uc007ubg.2 serine-type endopeptidase activity extracellular space cytoplasm proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc007ubg.1 uc007ubg.2 
ENSMUST00000089558.7 Snrpg ENSMUST00000089558.7 small nuclear ribonucleoprotein polypeptide G (from RefSeq NM_026506.2) ENSMUST00000089558.1 ENSMUST00000089558.2 ENSMUST00000089558.3 ENSMUST00000089558.4 ENSMUST00000089558.5 ENSMUST00000089558.6 NM_026506 P62309 Q15357 Q52KC7 RUXG_MOUSE uc009crm.1 uc009crm.2 uc009crm.3 Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. IAs a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing. Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with GEMIN2 (via N-terminus); the interaction is direct. Interacts with SNRPE; the interaction is direct. Cytoplasm, cytosol Nucleus Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. Belongs to the snRNP Sm proteins family. spliceosomal snRNP assembly mRNA splicing, via spliceosome RNA binding nucleus spliceosomal complex U5 snRNP U7 snRNP U1 snRNP U2 snRNP U4 snRNP U12-type spliceosomal complex cytoplasm cytosol mRNA processing RNA splicing methylosome SMN-Sm protein complex P granule U4/U6 x U5 tri-snRNP complex U2-type prespliceosome U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome U1 snRNP binding uc009crm.1 uc009crm.2 uc009crm.3 
ENSMUST00000089559.11 Ddrgk1 ENSMUST00000089559.11 DDRGK domain containing 1, transcript variant 7 (from RefSeq NR_184841.1) DDRGK_MOUSE Ddrgk1 ENSMUST00000089559.1 ENSMUST00000089559.10 ENSMUST00000089559.2 ENSMUST00000089559.3 ENSMUST00000089559.4 ENSMUST00000089559.5 ENSMUST00000089559.6 ENSMUST00000089559.7 ENSMUST00000089559.8 ENSMUST00000089559.9 NR_184841 Q14BT4 Q80WW9 Q9CT52 Ufbp1 uc008mjs.1 uc008mjs.2 uc008mjs.3 Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) (By similarity). In response to endoplasmic reticulum stress, promotes recruitment of the E3 UFM1-protein ligase UFL1 to the endoplasmic reticulum membrane: in turn, UFL1 mediates ufmylation of proteins such as RPN1 and RPL26/uL24, promoting reticulophagy of endoplasmic reticulum sheets (By similarity). Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability (PubMed:28128204). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis or inflammatory response (PubMed:30701081). Required for TRIP4 ufmylation, thereby regulating nuclear receptors-mediated transcription (PubMed:28263186). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:28263186). Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186). Interacts with TRIP4; the interaction with TRIP4 is direct. Interacts (via PCI domain) with UFL1. Interacts with (unphosphorylated) ERN1/IRE1-alpha; interaction is dependent on UFM1 and takes place in response to endoplasmic reticulum stress, regulating ERN1/IRE1-alpha stability. Interacts with NFKBIA. Interacts with CDK5RAP3. Interacts with SOX9. Endoplasmic reticulum Endoplasmic reticulum membrane Note=Localizes to the endoplasmic reticulum membrane in response to endoplasmic reticulum stress. Ubiquitously expressed (PubMed:20228063). Higher expression in pancreatic islets, pancreatic acini and testis (at protein level) (PubMed:21494687). Highly expressed in the intestinal exocrine cells (PubMed:30701081). Ufmylated; conjugated to ubiquitin-like protein UFM1, probably at Lys-268 by UFL1 (PubMed:21494687). The relevance of ufmylation is however unclear: as DDRGK1 acts as a substrate adapters for ufmylation, it is uncertain whether ufmylation is a collateral effect of ufmylation process or is required to regulate its activity (By similarity). Ubiquitinated. Ubiquitination probably triggers proteasomal degradation and is negatively regulated by UFL1, the enzyme involved in the ufmylation of DDRGK1. The knockout of the gene results in embryonic lethality between 11.5 and 12.5 dpc (PubMed:28263186). Chondrogenic mesenchymal condensation is absent in 12.5 dpc embryos (PubMed:28263186). Conditional deletion in intestinal epithelial cells causes a significant loss of both Paneth and goblet cells in intestine, which in turn results in dysbiotic microbiota and increased susceptibility to experimentally induced colitis (PubMed:30701081). Belongs to the DDRGK1 family. Sequence=AAH51541.1; Type=Erroneous initiation; Evidence=; RNA polymerase II repressing transcription factor binding protein binding nucleolus endoplasmic reticulum endoplasmic reticulum membrane positive regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression positive regulation of cell migration negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of intracellular estrogen receptor signaling pathway response to endoplasmic reticulum stress negative regulation of apoptotic process ubiquitin-like protein ligase binding positive regulation of transcription from RNA polymerase II promoter positive regulation of NF-kappaB transcription factor activity cartilage development positive regulation of proteasomal protein catabolic process positive regulation of I-kappaB phosphorylation positive regulation of metallopeptidase activity positive regulation of protein localization to endoplasmic reticulum positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding protein K69-linked ufmylation uc008mjs.1 uc008mjs.2 uc008mjs.3 
ENSMUST00000089578.9 Noto ENSMUST00000089578.9 notochord homeobox (from RefSeq NM_001007472.2) ENSMUST00000089578.1 ENSMUST00000089578.2 ENSMUST00000089578.3 ENSMUST00000089578.4 ENSMUST00000089578.5 ENSMUST00000089578.6 ENSMUST00000089578.7 ENSMUST00000089578.8 NM_001007472 NOTO_MOUSE Not Q5TIS6 uc009cpp.1 uc009cpp.2 uc009cpp.3 Transcription factor that controls node morphogenesis (PubMed:15231714, PubMed:17884984, PubMed:18061569, PubMed:22357932). Acts downstream of both FOXA2 and Brachyury (T) during notochord development (PubMed:15231714). Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function (PubMed:17884984). Plays a role in regulating axial versus paraxial cell fate (PubMed:18061569). Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (PubMed:27914912). Nucleus First detected at 7.5 dpc in the node at the distal tip of the egg cylinder and is largely confined to the ventral node. Between 8 dpc and 9 dpc, highly expressed in the node and newly formed notochord. At 12.5 dpc, expression is confined to the notochordal plate and caudal portion of the notochord. Note=Defects in Noto are the cause of the truncate (tc) phenotype. Truncate (tc) is a recessive mutation that affects the development of the caudal notochord. Mice homozygous for tc are viable but viability is reduced, which is attributed at least in part to spinal injury in the sacral and lower lumbar region. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding heart looping DNA binding nucleus regulation of transcription from RNA polymerase II promoter multicellular organism development determination of left/right symmetry central nervous system development embryonic pattern specification dorsal/ventral pattern formation neuron differentiation notochord development motile cilium assembly regulation of cilium assembly uc009cpp.1 uc009cpp.2 uc009cpp.3 
ENSMUST00000089581.11 Pced1a ENSMUST00000089581.11 PC-esterase domain containing 1A, transcript variant 1 (from RefSeq NM_178762.5) A2BI89 ENSMUST00000089581.1 ENSMUST00000089581.10 ENSMUST00000089581.2 ENSMUST00000089581.3 ENSMUST00000089581.4 ENSMUST00000089581.5 ENSMUST00000089581.6 ENSMUST00000089581.7 ENSMUST00000089581.8 ENSMUST00000089581.9 Fam113a NM_178762 PED1A_MOUSE Q6P1Z5 uc008miv.1 uc008miv.2 uc008miv.3 uc008miv.4 Belongs to the PC-esterase family. molecular_function cellular_component biological_process uc008miv.1 uc008miv.2 uc008miv.3 uc008miv.4 
ENSMUST00000089620.11 Cd86 ENSMUST00000089620.11 CD86 antigen (from RefSeq NM_019388.3) Cd86 ENSMUST00000089620.1 ENSMUST00000089620.10 ENSMUST00000089620.2 ENSMUST00000089620.3 ENSMUST00000089620.4 ENSMUST00000089620.5 ENSMUST00000089620.6 ENSMUST00000089620.7 ENSMUST00000089620.8 ENSMUST00000089620.9 NM_019388 Q549Q9 Q549Q9_MOUSE uc007zcq.1 uc007zcq.2 uc007zcq.3 Membrane ; Single- pass type I membrane protein membrane integral component of membrane uc007zcq.1 uc007zcq.2 uc007zcq.3 
ENSMUST00000089628.4 Csta3 ENSMUST00000089628.4 cystatin A family member 3 (from RefSeq NM_001082542.1) Csta3 D3Z5J1 EG408196 ENSMUST00000089628.1 ENSMUST00000089628.2 ENSMUST00000089628.3 Gm4758 Gm5416 NM_001082542 Q6IE28 Q6IE28_MOUSE Stfa1l1 uc007zci.1 uc007zci.2 Belongs to the cystatin family. endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity cytosol negative regulation of endopeptidase activity uc007zci.1 uc007zci.2 
ENSMUST00000089641.6 Tlx2 ENSMUST00000089641.6 T cell leukemia, homeobox 2 (from RefSeq NM_009392.2) B2RR62 ENSMUST00000089641.1 ENSMUST00000089641.2 ENSMUST00000089641.3 ENSMUST00000089641.4 ENSMUST00000089641.5 Enx Hox11l1 NM_009392 Ncx Q61663 TLX2_MOUSE Tlx1l1 uc009cme.1 uc009cme.2 uc009cme.3 Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract. Nucleus Detected in cranial ganglia at 9 dpc, and in dorsal root ganglia by 10.5 dpc. First detected in gut at 11.5 dpc, with a marked increase by 12.5 dpc. After birth, detected in myenteric and submucosal neurons innervating the distal ileum, colon and rectum. Mice are born at the expected Mendelian ratio and show no visible phenotype at birth. After weaning, about 43% of the mice exhibit distended abdomens and growth retardation, the others remain symptomless. About 36% of the mice die between 3 and 6 weeks after birth. Affected mice display distended proximal colons and cecums. Both affected and asymptotic mice have increased numbers of myenteric neurons in ganglia in the proximal and distal colon with a concomitant increase in myenteric ganglion size. In the urinary system, mice exhibit increased numbers of NADPH diaphorase positive neuronal cells in the vesical ganglia, and concomitant vesicourethral sphincter muscle dysfunction. Was originally thought to be the ortholog of human HOX11. transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding mesoderm formation DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter enteric nervous system development negative regulation of dendrite morphogenesis uc009cme.1 uc009cme.2 uc009cme.3 
ENSMUST00000089645.13 Htra2 ENSMUST00000089645.13 HtrA serine peptidase 2 (from RefSeq NM_019752.3) ENSMUST00000089645.1 ENSMUST00000089645.10 ENSMUST00000089645.11 ENSMUST00000089645.12 ENSMUST00000089645.2 ENSMUST00000089645.3 ENSMUST00000089645.4 ENSMUST00000089645.5 ENSMUST00000089645.6 ENSMUST00000089645.7 ENSMUST00000089645.8 ENSMUST00000089645.9 HTRA2_MOUSE NM_019752 Omi Prss25 Q9JIY5 Q9R108 uc009clu.1 uc009clu.2 uc009clu.3 uc009clu.4 uc009clu.5 Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase- independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis (By similarity). Reaction=Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.; EC=3.4.21.108; Homotrimer. Interacts with MXI2. Interacts with THAP5 under apoptotic conditions (By similarity). The mature protein, but not the precursor, binds to BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with AREL1 (via HECT domain); in the cytoplasm following induction of apoptosis (PubMed:23479728). Q9JIY5; O35387: Hax1; NbExp=3; IntAct=EBI-2365838, EBI-642449; Q9JIY5; Q99MS3: Mpv17l; NbExp=2; IntAct=EBI-2365838, EBI-15727135; Q9JIY5; Q99MS3-1: Mpv17l; NbExp=3; IntAct=EBI-2365838, EBI-15727082; Q9JIY5; Q99MS3-3: Mpv17l; NbExp=2; IntAct=EBI-2365838, EBI-15727109; Q9JIY5; Q60989: Xiap; NbExp=2; IntAct=EBI-2365838, EBI-517478; Q9JIY5; P98170: XIAP; Xeno; NbExp=4; IntAct=EBI-2365838, EBI-517127; Mitochondrion intermembrane space. Mitochondrion membrane ; Single-pass membrane protein Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with BID. The mature N-terminus is involved in the interaction with XIAP. The PDZ domain mediates interaction with MXI2. Autoproteolytically activated. Belongs to the peptidase S1C family. chromatin serine-type endopeptidase activity protein binding nucleus mitochondrion mitochondrial intermembrane space cytosol cytoskeleton proteolysis ceramide metabolic process apoptotic process mitochondrion organization aging adult walking behavior peptidase activity serine-type peptidase activity adult locomotory behavior intrinsic apoptotic signaling pathway in response to DNA damage response to herbicide cytoplasmic side of plasma membrane positive regulation of mitochondrion organization positive regulation of cell death membrane integral component of membrane hydrolase activity pentacyclic triterpenoid metabolic process forebrain development mitochondrial membrane cellular response to oxidative stress cellular response to heat cellular response to interferon-beta CD40 receptor complex regulation of multicellular organism growth identical protein binding positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process cellular protein catabolic process neuron development negative regulation of cell death protein homotrimerization cellular response to retinoic acid cellular response to growth factor stimulus intrinsic apoptotic signaling pathway negative regulation of mitophagy in response to mitochondrial depolarization serine-type endopeptidase complex positive regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway uc009clu.1 uc009clu.2 uc009clu.3 uc009clu.4 uc009clu.5 
ENSMUST00000089651.6 Dok1 ENSMUST00000089651.6 docking protein 1, transcript variant 2 (from RefSeq NR_176878.1) DOK1_MOUSE Dok ENSMUST00000089651.1 ENSMUST00000089651.2 ENSMUST00000089651.3 ENSMUST00000089651.4 ENSMUST00000089651.5 NR_176878 P97465 Q9R213 uc009clr.1 uc009clr.2 uc009clr.3 uc009clr.4 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). Interacts with RasGAP, INPP5D/SHIP1 and ABL1. Interacts directly with phosphorylated ITGB3 (By similarity). Interacts with SRMS (via the SH2 and SH3 domains) (By similarity). P97465; P00520: Abl1; NbExp=4; IntAct=EBI-914917, EBI-914519; P97465; Q99M51: Nck1; NbExp=5; IntAct=EBI-914917, EBI-642202; Cytoplasm Nucleus Expressed in lung, spleen, skeletal muscle and kidney. PTB domain mediates receptor interaction. Constitutively tyrosine-phosphorylated. Phosphorylated by TEC. Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway (By similarity). Phosphorylated by LYN. Phosphorylated on tyrosine residues by SRMS (By similarity). No visible phenotype. Mice appear healthy and are fertile. Belongs to the DOK family. Type A subfamily. protein binding nucleus cytoplasm cytosol transmembrane receptor protein tyrosine kinase signaling pathway Ras protein signal transduction intracellular signal transduction macrophage colony-stimulating factor signaling pathway negative regulation of MAPK cascade uc009clr.1 uc009clr.2 uc009clr.3 uc009clr.4 
ENSMUST00000089654.4 BC024139 ENSMUST00000089654.4 BC024139 (from geneSymbol) AK081549 BC024139 E9PXU3 E9PXU3_MOUSE ENSMUST00000089654.1 ENSMUST00000089654.2 ENSMUST00000089654.3 uc007wiq.1 uc007wiq.2 uc007wiq.3 uc007wiq.4 molecular_function cytoplasm cytoskeleton microtubule microtubule binding actin cytoskeleton membrane regulation of microtubule-based process wound healing intermediate filament cytoskeleton organization regulation of focal adhesion assembly intermediate filament uc007wiq.1 uc007wiq.2 uc007wiq.3 uc007wiq.4 
ENSMUST00000089667.8 Reg3d ENSMUST00000089667.8 regenerating islet-derived 3 delta, transcript variant 1 (from RefSeq NM_013893.2) ENSMUST00000089667.1 ENSMUST00000089667.2 ENSMUST00000089667.3 ENSMUST00000089667.4 ENSMUST00000089667.5 ENSMUST00000089667.6 ENSMUST00000089667.7 NM_013893 Q9QUS9 Q9QUS9_MOUSE Reg3d uc009cjx.1 uc009cjx.2 uc009cjx.3 transmembrane signaling receptor activity extracellular space positive regulation of cell proliferation carbohydrate binding peptidoglycan binding response to peptide hormone cell wall disruption in other organism oligosaccharide binding uc009cjx.1 uc009cjx.2 uc009cjx.3 
ENSMUST00000089669.6 Mapk15 ENSMUST00000089669.6 mitogen-activated protein kinase 15, transcript variant 1 (from RefSeq NM_177922.3) ENSMUST00000089669.1 ENSMUST00000089669.2 ENSMUST00000089669.3 ENSMUST00000089669.4 ENSMUST00000089669.5 Erk7 Erk8 MK15_MOUSE Mapk15 NM_177922 Q80Y86 uc007whz.1 uc007whz.2 uc007whz.3 Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (By similarity) (PubMed:25823377). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation. Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling. Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins. Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion. Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA. Regulates DA transporter (DAT) activity and protein expression via activation of RhoA. In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (By similarity). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (By similarity). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (PubMed:23351492). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Activated by threonine and tyrosine phosphorylation (By similarity). Inhibited by dual specificity phosphatases, such as DUSP1 (By similarity). Phosphorylation and activation in response to DNA damaging agents, serum stimulation. Constitutively activated when phosphorylated on Tyr-178. Activity depends on the relative rates of MAPK15 autophosphorylation and dephosphorylation by PTPN1 (By similarity). Interacts with TGFB1I1 (PubMed:16624805). Interacts with CSK/c-Src, ABL1 and RET. Interacts with GABARAP, MAP1LC3B and GABARAPL1; controls, in a kinase-dependent fashion, both basal and starvation-induced autophagy. Interacts with ESRRA; promotes re- localization of ESRRA to the cytoplasm through a XPO1-dependent mechanism then inhibits ESRRA transcriptional activity. Interacts with PCNA; the interaction is chromatin binding- and kinase activity- dependent and prevents MDM2-mediated PCNA destruction by inhibiting the association of PCNA with MDM2 (By similarity). Interacts with DVL2 (PubMed:25823377). Interacts with CLIC3; MAPK15 does not phosphorylates CLIC3 (By similarity). Cytoplasm, cytoskeleton, cilium basal body Cell junction, tight junction Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasmic vesicle, autophagosome Golgi apparatus Nucleus Cytoplasm Cytoplasm, cytoskeleton, spindle Note=Co-localizes to the cytoplasm only in presence of ESRRA. Translocates to the nucleus upon activation (By similarity). At prometaphase I, metaphase I (MI), anaphase I, telophase I, and metaphase II (MII) stages, is stably detected at the spindle (PubMed:23351492). Expressed at all stages of oocyte meiotic maturation. The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. Autophosphorylated on Thr-176 and Tyr-178; activates the enzyme. Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. negative regulation of transcription from RNA polymerase II promoter MAPK cascade nucleotide binding positive regulation of protein phosphorylation regulation of COPII vesicle coating chromatin binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity protein binding ATP binding nucleus cytoplasm autophagosome Golgi apparatus centriole spindle cytoskeleton cell-cell junction bicellular tight junction protein phosphorylation cellular response to DNA damage stimulus endoplasmic reticulum organization negative regulation of DNA replication positive regulation of cell proliferation regulation of gene expression regulation of autophagy kinase activity phosphorylation transferase activity cell junction negative regulation of cell migration positive regulation of protein ubiquitination cytoplasmic vesicle positive regulation of telomere maintenance via telomerase response to estradiol intracellular signal transduction ciliary basal body cell projection positive regulation of protein catabolic process protein autophosphorylation positive regulation of telomerase activity meiotic spindle dopamine uptake regulation of cilium assembly positive regulation of telomere capping protein localization to ciliary transition zone positive regulation of metaphase/anaphase transition of meiosis I uc007whz.1 uc007whz.2 uc007whz.3 
ENSMUST00000089673.10 Astl ENSMUST00000089673.10 astacin like metalloendopeptidase, transcript variant 1 (from RefSeq NM_001291003.1) A2AHU0 A2AHU1 ASTL_MOUSE Astl ENSMUST00000089673.1 ENSMUST00000089673.2 ENSMUST00000089673.3 ENSMUST00000089673.4 ENSMUST00000089673.5 ENSMUST00000089673.6 ENSMUST00000089673.7 ENSMUST00000089673.8 ENSMUST00000089673.9 G7Z016 G7Z017 G7Z018 G7Z019 NM_001291003 Q6HA09 Q8BMA1 Sas1b uc008mfh.1 uc008mfh.2 uc008mfh.3 uc008mfh.4 uc008mfh.5 uc008mfh.6 Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. Inhibited by wide spectrum metalloproteinase inhibitor batimastat (BB-94). Also inhibited by EDTA (By similarity). Interacts (via N-terminal domain) with SPACA3; the interaction occurs during fertilization. Cytoplasm ll membrane Cytoplasmic vesicle, secretory vesicle, Cortical granule Note=Probably exocytosed from cortical granules during post-fertilization. Detected throughout the ooplasm of germinal vesicle stage oocytes in early bilaminar secondary follicles at postnatal (PN) day 3. Detected in the microvillar domain of the oolemma in arrested ovulated secondary oocytes and in the first polar body prior to fertilization. Upon fertilization, detected in the perivitelline space (PVS) and occasionally on the oolemma in 2-cell through morulae stages. Colocalizes with SPACA3 at the microvillar domain of the oolemma and in the perivitelline space (PVS). Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=V1; IsoId=Q6HA09-1; Sequence=Displayed; Name=2 ; Synonyms=V2; IsoId=Q6HA09-2; Sequence=VSP_051832; Name=3; Synonyms=V6; IsoId=Q6HA09-3; Sequence=VSP_043998; Name=4; Synonyms=V4; IsoId=Q6HA09-4; Sequence=VSP_043997; Name=5; Synonyms=V5; IsoId=Q6HA09-5; Sequence=VSP_051832, VSP_043999; Name=6; Synonyms=V3; IsoId=Q6HA09-6; Sequence=VSP_051832, VSP_043997; Ovary-specific. Expressed in secondary, antral and Graafian follicle oocytes. Expressed in the egg cells. Not detected in two-cell embryos. Not detected in naked oocytes, oocytes in primordial or unilaminar primary follicles, or in any other ovarian cells at pre- pubertal, pubertal or adult stages (at protein level). Ovary-specific. Expressed in embryonic stem cells. Absence of cortical granules exocytosis during post-fertilization. Multiple capacitated sperm binding to eggs and two- cell embryos are not prevented. Post-fertilization cleavage of ZP2 does not occur. Name=Protein Spotlight; Note=Life's boundaries - Issue 141 of September 2012; URL="https://web.expasy.org/spotlight/back_issues/141"; metalloendopeptidase activity protein binding cytoplasm plasma membrane proteolysis cell adhesion single fertilization peptidase activity metallopeptidase activity zinc ion binding fertilization positive regulation of protein processing membrane hydrolase activity transport vesicle cytoplasmic vesicle metal ion binding prevention of polyspermy cortical granule aspartic-type peptidase activity glutamic-type peptidase activity negative regulation of binding of sperm to zona pellucida uc008mfh.1 uc008mfh.2 uc008mfh.3 uc008mfh.4 uc008mfh.5 uc008mfh.6 
ENSMUST00000089688.6 Mmp14 ENSMUST00000089688.6 matrix metallopeptidase 14 (membrane-inserted) (from RefSeq NM_008608.4) ENSMUST00000089688.1 ENSMUST00000089688.2 ENSMUST00000089688.3 ENSMUST00000089688.4 ENSMUST00000089688.5 MMP14_MOUSE Mtmmp NM_008608 O08645 O35369 P53690 Q8BTX2 uc007twc.1 uc007twc.2 uc007twc.3 uc007twc.4 uc007twc.5 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues. [provided by RefSeq, Feb 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC076638.1, AK155117.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (PubMed:10520996). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (By similarity). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues (By similarity). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (By similarity). Reaction=Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|- Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.; EC=3.4.24.80; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts (via C-terminal cytoplasmic tail) with BST2. Interacts with DLL1; inhibits DLL1-induced Notch signaling. Membrane ; Single-pass type I membrane protein ; Extracellular side Melanosome Cytoplasm Note=Forms a complex with BST2 and localizes to the cytoplasm. Highly expressed in placenta, kidney, heart, lung, embryonic skeletal and periskeletal tissues. Not detected before day 10.5. At day 12.5, prominently expressed in large arteries and the umbilical arteries, expressed at lower levels in the myocardium, craniofacial mesenchyme, nasal epithelium and liver capsule. At days 14.5 and 17.5, expressed in the musculoskeletal system, and ossification areas, with continued expression in the arterial tunica media. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Tyrosine phosphorylated by PKDCC/VLK. Belongs to the peptidase M10A family. skeletal system development ossification angiogenesis ovarian follicle development response to hypoxia endothelial cell proliferation endochondral ossification endopeptidase activity metalloendopeptidase activity integrin binding extracellular space nucleus cytoplasm cytosol plasma membrane proteolysis response to oxidative stress peptidase activity metallopeptidase activity zinc ion binding male gonad development response to mechanical stimulus response to hormone positive regulation of myotube differentiation positive regulation of protein processing response to organic cyclic compound membrane integral component of membrane cell migration hydrolase activity extracellular matrix organization positive regulation of cell growth lung development positive regulation of cell migration collagen catabolic process extracellular matrix cytoplasmic vesicle zymogen activation endodermal cell differentiation chondrocyte proliferation melanosome astrocyte cell migration response to estrogen macropinosome intermediate filament cytoskeleton positive regulation of B cell differentiation negative regulation of Notch signaling pathway metal ion binding embryonic cranial skeleton morphogenesis branching morphogenesis of an epithelial tube tissue remodeling negative regulation of focal adhesion assembly head development bone development metalloaminopeptidase activity craniofacial suture morphogenesis regulation of protein localization to plasma membrane positive regulation of macrophage migration response to odorant uc007twc.1 uc007twc.2 uc007twc.3 uc007twc.4 uc007twc.5 
ENSMUST00000089759.9 Bdh1 ENSMUST00000089759.9 3-hydroxybutyrate dehydrogenase, type 1, transcript variant 1 (from RefSeq NM_175177.4) BDH_MOUSE Bdh Bdh1 ENSMUST00000089759.1 ENSMUST00000089759.2 ENSMUST00000089759.3 ENSMUST00000089759.4 ENSMUST00000089759.5 ENSMUST00000089759.6 ENSMUST00000089759.7 ENSMUST00000089759.8 NM_175177 Q3UJS9 Q3UL45 Q80XN0 Q8BK53 Q8R0C8 uc007yxi.1 uc007yxi.2 uc007yxi.3 uc007yxi.4 Reaction=(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH; Xref=Rhea:RHEA:20521, ChEBI:CHEBI:10983, ChEBI:CHEBI:13705, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.30; Evidence=; Requires phosphatidylcholine as an allosteric activator for enzymatic activity. Homotetramer. Mitochondrion inner membrane Mitochondrion matrix Acetylation of Lys-132 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the short-chain dehydrogenases/reductases (SDR) family. catalytic activity 3-hydroxybutyrate dehydrogenase activity phospholipid binding nucleoplasm mitochondrion mitochondrial inner membrane mitochondrial matrix metabolic process membrane oxidoreductase activity oxidation-reduction process matrix side of mitochondrial inner membrane uc007yxi.1 uc007yxi.2 uc007yxi.3 uc007yxi.4 
ENSMUST00000089765.9 Chrac1 ENSMUST00000089765.9 chromatin accessibility complex 1 (from RefSeq NM_053068.3) CHRC1_MOUSE ENSMUST00000089765.1 ENSMUST00000089765.2 ENSMUST00000089765.3 ENSMUST00000089765.4 ENSMUST00000089765.5 ENSMUST00000089765.6 ENSMUST00000089765.7 ENSMUST00000089765.8 NM_053068 Q91VG2 Q9JKP8 uc007wbq.1 uc007wbq.2 uc007wbq.3 Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (By similarity). Heterodimer with POLE3; binds to DNA (By similarity). Component of the CHRAC ISWI chromatin remodeling complex at least composed of SMARCA5/SNF2H, BAZ1A/ACF1, CHRAC1 and POLE3; the complex preferentially binds DNA through the CHRAC1-POLE3 heterodimer and possesses ATP-dependent nucleosome-remodeling activity (By similarity). Within the complex, the heterodimer with POLE3 interacts with SMARCA5/SNF2H; the interaction is direct and enhances nucleosome sliding activity by the SMARCA5/SNF2H and BAZ1A/ACF1 interaction (By similarity). Within the complex, the heterodimer with POLE3 interacts with BAZ1A/ACF1; the interactions are direct (By similarity). Nucleus Ubiquitously expressed. DNA binding transcription factor activity, sequence-specific DNA binding DNA-directed DNA polymerase activity protein binding nucleus regulation of transcription, DNA-templated transferase activity nucleotidyltransferase activity protein heterodimerization activity DNA biosynthetic process uc007wbq.1 uc007wbq.2 uc007wbq.3 
ENSMUST00000089770.11 Trappc9 ENSMUST00000089770.11 trafficking protein particle complex 9, transcript variant 2 (from RefSeq NM_180662.2) ENSMUST00000089770.1 ENSMUST00000089770.10 ENSMUST00000089770.2 ENSMUST00000089770.3 ENSMUST00000089770.4 ENSMUST00000089770.5 ENSMUST00000089770.6 ENSMUST00000089770.7 ENSMUST00000089770.8 ENSMUST00000089770.9 Kiaa1882 NM_180662 Nibp Q3U0M1 Q3UU81 Q69Z79 Q6NS50 Q8CD01 Q8CFV8 Q9D8R6 TPPC9_MOUSE uc007wbm.1 uc007wbm.2 Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12 (By similarity). Directly interacts with IKBKB and MAP3K14. Golgi apparatus, cis-Golgi network Endoplasmic reticulum Cytoplasm Note=Processes and cell bodies of neurons. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q3U0M1-1; Sequence=Displayed; Name=2; IsoId=Q3U0M1-2; Sequence=VSP_034353; Name=3; IsoId=Q3U0M1-3; Sequence=VSP_034351, VSP_034352; Name=4; IsoId=Q3U0M1-4; Sequence=VSP_034353, VSP_034356; Name=5; IsoId=Q3U0M1-5; Sequence=VSP_034353, VSP_034354, VSP_034355; Expressed in neurons of the pyramidal layer of the cortex, in spinal cord motor neurons and white matter neurons (at protein level). Belongs to the NIBP family. Sequence=BAB25242.1; Type=Erroneous initiation; Evidence=; protein binding cytoplasm endoplasmic reticulum trans-Golgi network cerebral cortex development TRAPP complex cell differentiation neuron differentiation positive regulation of NF-kappaB transcription factor activity early endosome late endosome Golgi apparatus uc007wbm.1 uc007wbm.2 
ENSMUST00000089771.4 Rnase13 ENSMUST00000089771.4 ribonuclease, RNase A family, 13 (non-active) (from RefSeq NM_001011687.3) ENSMUST00000089771.1 ENSMUST00000089771.2 ENSMUST00000089771.3 NM_001011687 Q5GAM7 RNS13_MOUSE uc007tnn.1 uc007tnn.2 uc007tnn.3 uc007tnn.4 Does not exhibit any ribonuclease activity. Secreted Belongs to the pancreatic ribonuclease family. nucleic acid binding cellular_component extracellular region RNA phosphodiester bond hydrolysis ribonuclease activity uc007tnn.1 uc007tnn.2 uc007tnn.3 uc007tnn.4 
ENSMUST00000089776.3 Cep152 ENSMUST00000089776.3 centrosomal protein 152 (from RefSeq NM_001081091.1) A2AUM9 CE152_MOUSE ENSMUST00000089776.1 ENSMUST00000089776.2 Kiaa0912 NM_001081091 Q69ZV8 Q8R0X1 uc008mcs.1 uc008mcs.2 Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (By similarity). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (By similarity). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (PubMed:24240477). Overexpression of cep152 can drive amplification of centrioles. Interacts (via N-terminus) with PLK4; the interaction is mutally exclusive with a PLK4:CEP192 interaction. Interacts (via C- terminus) with CENPJ (via-N-terminus). Interacts with CINP. Interacts with CDK5RAP2, WDR62, CEP63 and CEP131. CEP63, CDK5RAP2, CEP152, WDR62 are proposed to form a stepwise assembled complex at the centrosome forming a ring near parental centrioles (By similarity). Interacts with DEUP1; this interaction recruits CEP152 to the deuterosome. The interactions with CEP63 and DEUP1 are mutually exclusive (PubMed:24240477). A2AUM9; Q3UPP8: Cep63; NbExp=2; IntAct=EBI-2554268, EBI-16081652; A2AUM9; Q7M6Y5: Deup1; NbExp=2; IntAct=EBI-2554268, EBI-16081624; A2AUM9; Q96MT8: CEP63; Xeno; NbExp=3; IntAct=EBI-2554268, EBI-741977; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Colocalizes with CDK5RAP2, WDR62 and CEP63 in a discrete ring around the proximal end of the parental centriole (By similarity). At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles (By similarity). Localizes to the deuterosome (PubMed:24240477). Localizes to pericentriolar material (PCM) (By similarity). Belongs to the CEP152 family. Sequence=BAD32338.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; pericentriolar material protein binding nucleoplasm cytoplasm centrosome centriole microtubule organizing center cytoskeleton centriole replication protein kinase binding cell projection organization centrosome duplication de novo centriole assembly involved in multi-ciliated epithelial cell differentiation deuterosome uc008mcs.1 uc008mcs.2 
ENSMUST00000089824.11 Plaat1 ENSMUST00000089824.11 phospholipase A and acyltransferase 1, transcript variant 1 (from RefSeq NM_013751.7) A0A0R4J130 A0A0R4J130_MOUSE ENSMUST00000089824.1 ENSMUST00000089824.10 ENSMUST00000089824.2 ENSMUST00000089824.3 ENSMUST00000089824.4 ENSMUST00000089824.5 ENSMUST00000089824.6 ENSMUST00000089824.7 ENSMUST00000089824.8 ENSMUST00000089824.9 Hrasls NM_013751 Plaat1 uc007yvw.1 uc007yvw.2 uc007yvw.3 Belongs to the H-rev107 family. phospholipase activity membrane integral component of membrane uc007yvw.1 uc007yvw.2 uc007yvw.3 
ENSMUST00000089830.4 Vmn1r19 ENSMUST00000089830.4 vomeronasal 1 receptor 19 (from RefSeq NM_134182.1) ENSMUST00000089830.1 ENSMUST00000089830.2 ENSMUST00000089830.3 NM_134182 Q8R2C7 Q8R2C7_MOUSE V1rc27 Vmn1r19 uc009ccf.1 uc009ccf.2 uc009ccf.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009ccf.1 uc009ccf.2 uc009ccf.3 
ENSMUST00000089860.12 Fam13a ENSMUST00000089860.12 family with sequence similarity 13, member A (from RefSeq NM_153574.2) ENSMUST00000089860.1 ENSMUST00000089860.10 ENSMUST00000089860.11 ENSMUST00000089860.2 ENSMUST00000089860.3 ENSMUST00000089860.4 ENSMUST00000089860.5 ENSMUST00000089860.6 ENSMUST00000089860.7 ENSMUST00000089860.8 ENSMUST00000089860.9 FA13A_MOUSE Fam13a1 NM_153574 Precm1 Q8BGI4 Q8BZ91 uc009cdi.1 uc009cdi.2 uc009cdi.3 Expressed in the mammary gland, with similar levels at all stages of development, including pregnancy, lactation and involution. Belongs to the FAM13 family. molecular_function cellular_component biological_process uc009cdi.1 uc009cdi.2 uc009cdi.3 
ENSMUST00000089874.9 Mcc ENSMUST00000089874.9 mutated in colorectal cancers, transcript variant 1 (from RefSeq NM_001085373.1) E9PWI3 E9PWI3_MOUSE ENSMUST00000089874.1 ENSMUST00000089874.2 ENSMUST00000089874.3 ENSMUST00000089874.4 ENSMUST00000089874.5 ENSMUST00000089874.6 ENSMUST00000089874.7 ENSMUST00000089874.8 Mcc NM_001085373 uc008euz.1 uc008euz.2 calcium ion binding nucleus nucleoplasm cytoplasm cytosol plasma membrane negative regulation of epithelial cell migration establishment of protein localization negative regulation of epithelial cell proliferation negative regulation of canonical Wnt signaling pathway uc008euz.1 uc008euz.2 
ENSMUST00000089883.7 Masp1 ENSMUST00000089883.7 MBL associated serine protease 1, transcript variant 2 (from RefSeq NM_008555.3) A2RRH8 A2RRH9 Crarf ENSMUST00000089883.1 ENSMUST00000089883.2 ENSMUST00000089883.3 ENSMUST00000089883.4 ENSMUST00000089883.5 ENSMUST00000089883.6 MASP1_MOUSE Masp3 NM_008555 P98064 Q8CD27 Q8CIR8 Q920S0 uc007ytr.1 uc007ytr.2 uc007ytr.3 Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development. Inhibited by SERPING1 and A2M. Homodimer. Interacts with the oligomeric lectins MBL2, FCN2 and FCN3; triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1. Interacts with COLEC11; probably triggers the lectin pathway of complement. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=MASP-1; IsoId=P98064-1; Sequence=Displayed; Name=2; Synonyms=MASP-3; IsoId=P98064-2; Sequence=VSP_036814, VSP_036815; Protein of the plasma which is primarily expressed by liver. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. N-glycosylated. Some N-linked glycan are of the complex-type (By similarity). Autoproteolytic processing of the proenzyme produces the active enzyme composed on the heavy and the light chain held together by a disulfide bond. Isoform 1 but not isoform 2 is activated through autoproteolytic processing (By similarity). Mice are smaller and more vulnerable indicating developmental and growth defects. Mice serum has low C4 and C3 cleavage activity together with low MASP2 activation. [Isoform 2]: Contains a N-linked (GlcNAc...) asparagine at position 538 Contains a N-linked (GlcNAc...) asparagine at position 604. Belongs to the peptidase S1 family. complement activation, lectin pathway immune system process serine-type endopeptidase activity calcium ion binding extracellular region extracellular space nucleoplasm cytosol proteolysis peptidase activity serine-type peptidase activity hydrolase activity protein homodimerization activity innate immune response metal ion binding calcium-dependent protein binding uc007ytr.1 uc007ytr.2 uc007ytr.3 
ENSMUST00000089925.10 Dgkg ENSMUST00000089925.10 diacylglycerol kinase, gamma, transcript variant 1 (from RefSeq NM_138650.2) DGKG_MOUSE Dagk3 ENSMUST00000089925.1 ENSMUST00000089925.2 ENSMUST00000089925.3 ENSMUST00000089925.4 ENSMUST00000089925.5 ENSMUST00000089925.6 ENSMUST00000089925.7 ENSMUST00000089925.8 ENSMUST00000089925.9 NM_138650 Q91WG7 uc007ysg.1 uc007ysg.2 uc007ysg.3 uc007ysg.4 uc007ysg.5 Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:32033984). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:32033984). Has no apparent specificity with regard to the acyl compositions of diacylglycerol (By similarity). Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma (PubMed:32033984). Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (PubMed:32033984). Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10273; Evidence=; Reaction=1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43428, ChEBI:CHEBI:15378, ChEBI:CHEBI:18155, ChEBI:CHEBI:30616, ChEBI:CHEBI:78227, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43429; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40339, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77097, ChEBI:CHEBI:77098, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40340; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40324; Evidence=; The activity is calcium-dependent (By similarity). Requires phosphatidylserine for maximal activity (By similarity). Lipid metabolism; glycerolipid metabolism. Membrane Cytoplasm, cytosol Cytoplasm, cytoskeleton Expressed in hippocampus and cerebellar Purkinje cells and weakly and diffusely expressed in the granule cells. Homozygous knockout mice show impairments in motor coordination, long-term depression/LTD and development of Purkinje cells (PubMed:32033984). The level of phosphatidic acid in synaptosomal membranes is significantly decreased (PubMed:32033984). The number of branches, the total length of the dendrites and the membrane capacitance of the distal dendritic region are significantly lower (PubMed:32033984). Belongs to the eukaryotic diacylglycerol kinase family. nucleotide binding NAD+ kinase activity diacylglycerol kinase activity calcium ion binding ATP binding plasma membrane signal transduction protein kinase C-activating G-protein coupled receptor signaling pathway kinase activity phosphorylation transferase activity intracellular signal transduction diacylglycerol metabolic process glycerolipid metabolic process lipid phosphorylation metal ion binding neuron development uc007ysg.1 uc007ysg.2 uc007ysg.3 uc007ysg.4 uc007ysg.5 
ENSMUST00000089926.6 Mfap1a ENSMUST00000089926.6 microfibrillar-associated protein 1A (from RefSeq NM_026220.4) C0HKD9 ENSMUST00000089926.1 ENSMUST00000089926.2 ENSMUST00000089926.3 ENSMUST00000089926.4 ENSMUST00000089926.5 MFA1B_MOUSE Mfap1b NM_026220 Q3TU29 Q8CCL1 Q9CQU1 Q9CSJ5 uc008lzh.1 uc008lzh.2 uc008lzh.3 Involved in pre-mRNA splicing as a component of the spliceosome. Component of the spliceosome B complex. Interacts with PRPF38A (via N-terminal interaction domain). Nucleus Belongs to the MFAP1 family. mRNA splicing, via spliceosome microfibril extracellular matrix structural constituent nucleus spliceosomal complex mRNA processing biological_process RNA splicing U2-type precatalytic spliceosome uc008lzh.1 uc008lzh.2 uc008lzh.3 
ENSMUST00000089948.6 Slc44a5 ENSMUST00000089948.6 solute carrier family 44, member 5 (from RefSeq NM_001081263.1) CTL5_MOUSE Ctl5 ENSMUST00000089948.1 ENSMUST00000089948.2 ENSMUST00000089948.3 ENSMUST00000089948.4 ENSMUST00000089948.5 NM_001081263 Q5RJI2 uc008ruk.1 uc008ruk.2 uc008ruk.3 Choline/H+ antiporter. Reaction=choline(out) + n H(+)(in) = choline(in) + n H(+)(out); Xref=Rhea:RHEA:75463, ChEBI:CHEBI:15354, ChEBI:CHEBI:15378; Evidence=; Cell membrane ; Multi-pass membrane protein Belongs to the CTL (choline transporter-like) family. molecular_function cellular_component biological_process membrane integral component of membrane uc008ruk.1 uc008ruk.2 uc008ruk.3 
ENSMUST00000089950.11 Rabggtb ENSMUST00000089950.11 Rab geranylgeranyl transferase, b subunit, transcript variant 2 (from RefSeq NM_001163478.1) ENSMUST00000089950.1 ENSMUST00000089950.10 ENSMUST00000089950.2 ENSMUST00000089950.3 ENSMUST00000089950.4 ENSMUST00000089950.5 ENSMUST00000089950.6 ENSMUST00000089950.7 ENSMUST00000089950.8 ENSMUST00000089950.9 NM_001163478 Q3TVF4 Q3TVF4_MOUSE Rabggtb uc012czt.1 uc012czt.2 uc012czt.3 Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537, ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533, ChEBI:CHEBI:86021; EC=2.5.1.60; Evidence= Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Belongs to the protein prenyltransferase subunit beta family. catalytic activity prenyltransferase activity Rab geranylgeranyltransferase activity Rab-protein geranylgeranyltransferase complex transferase activity protein geranylgeranylation metal ion binding uc012czt.1 uc012czt.2 uc012czt.3 
ENSMUST00000089959.7 Gch1 ENSMUST00000089959.7 GTP cyclohydrolase 1 (from RefSeq NM_008102.4) ENSMUST00000089959.1 ENSMUST00000089959.2 ENSMUST00000089959.3 ENSMUST00000089959.4 ENSMUST00000089959.5 ENSMUST00000089959.6 Gch1 NM_008102 Q3U7P6 Q3U7P6_MOUSE uc007tht.1 uc007tht.2 uc007tht.3 Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. Cytoplasm Nucleus Belongs to the GTP cyclohydrolase I family. GTPase activity GTP cyclohydrolase I activity calcium ion binding GTP binding nucleus nucleoplasm cytoplasm cytosol tetrahydrobiopterin biosynthetic process regulation of blood pressure zinc ion binding hydrolase activity GTP-dependent protein binding translation initiation factor binding cytoplasmic vesicle nuclear membrane response to lipopolysaccharide macromolecular complex response to interferon-gamma response to tumor necrosis factor vasodilation dopamine biosynthetic process pteridine-containing compound biosynthetic process protein homodimerization activity negative regulation of blood pressure tetrahydrofolate biosynthetic process response to pain coenzyme binding neuromuscular process controlling posture positive regulation of nitric-oxide synthase activity mitogen-activated protein kinase binding dihydrobiopterin metabolic process protein homooligomerization protein heterooligomerization macromolecular complex assembly regulation of removal of superoxide radicals uc007tht.1 uc007tht.2 uc007tht.3 
ENSMUST00000090006.12 Itgb1 ENSMUST00000090006.12 integrin beta 1 (fibronectin receptor beta) (from RefSeq NM_010578.2) ENSMUST00000090006.1 ENSMUST00000090006.10 ENSMUST00000090006.11 ENSMUST00000090006.2 ENSMUST00000090006.3 ENSMUST00000090006.4 ENSMUST00000090006.5 ENSMUST00000090006.6 ENSMUST00000090006.7 ENSMUST00000090006.8 ENSMUST00000090006.9 F6R105 ITB1_MOUSE Itgb1 NM_010578 P09055 Q3TIW5 Q3TWH6 Q60993 Q61126 Q8BTU0 Q8BVU1 uc009nzv.1 uc009nzv.2 uc009nzv.3 uc009nzv.4 Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (PubMed:10634791, PubMed:36812915). Integrin alpha- 4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition (PubMed:12941630). Involved in promoting endothelial cell motility and angiogenesis (PubMed:15181153). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules (PubMed:21768292). May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (PubMed:18804435). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (By similarity). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G- D-dependent cell adhesion to FBN1 (By similarity). ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (By similarity). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (PubMed:22654117). Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA- mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction (PubMed:35802072). [Isoform 2]: Isoform 2 displaces isoform 1 in striated muscles. Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner (By similarity). Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion (PubMed:10634791). Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB, FLNC and RANBP9. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with RAB21. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with MYO10. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with DAB2. Interacts with FGR and HCK. Isoform 2 interacts with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 2 interacts with alpha-7B in cardiomyocytes of adult heart. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has a heterodimer form (PubMed:12189152). ITGA5:ITGB1 interacts with CCN3 (By similarity). ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (By similarity). ITGA5:ITGB1 interacts with FBN1 (By similarity). ITGA5:ITGB1 interacts with IL1B. Interacts with MDK (PubMed:15466886). ITGA4:ITGB1 interacts with MDK; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite-outgrowth (PubMed:15466886). ITGA5:ITGB1 interacts with ACE2 (By similarity). Interacts with TMEM182 (By similarity). Interacts with LAMB1 (PubMed:34427057). Interacts with tensin TNS3; TNS3 also interacts with PEAK1, thus acting as an adapter molecule to bridge the association of PEAK1 with ITGB1 (PubMed:35687021). Interacts with tensin TNS4; the interaction displaces tensin TNS3 from the ITGB1 cytoplasmic tail and promotes ITGB1 stability (By similarity). Integrin ITGA9:ITGB1 interacts with SPP1/OPN (via N-terminus) (PubMed:22654117). Integrin ITGA9:ITGB1 interacts with TNC/TNFN3 (via the 3rd Fibronectin type-III domain) (PubMed:22654117). Integrins ITGA4:ITGB1 and ITGA9:ITGB1 interact with SVEP1 (via Sushi domain 21); thereby inhibit Ca(2+) intracellular signaling and as a result repress vasocontraction (PubMed:22654117, PubMed:28179430). P09055; P26955: Csf2rb; NbExp=2; IntAct=EBI-644224, EBI-1810026; P09055; Q01768: Nme2; NbExp=3; IntAct=EBI-644224, EBI-642573; P09055; Q6F5E0: Tmem158; NbExp=3; IntAct=EBI-644224, EBI-645317; P09055; Q91YD9: Wasl; NbExp=2; IntAct=EBI-644224, EBI-642417; Cell membrane ; Single-pass type I membrane protein Cell projection, invadopodium membrane ; Single-pass type I membrane protein Cell projection, ruffle membrane ; Single-pass type I membrane protein Recycling endosome lanosome Cell projection, lamellipodium Cell projection, ruffle Cell junction, focal adhesion Note=Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions to fibrillar adhesions in an ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. [Isoform 2]: Cell membrane, sarcolemma Cell junction Note=In cardiac muscle, found in costameres and intercalated disks. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Beta-1A ; IsoId=P09055-1; Sequence=Displayed; Name=2; Synonyms=Beta-1D ; IsoId=P09055-2; Sequence=VSP_053581, VSP_053582; Expressed in the media layer of the arterial wall (at protein level). [Isoform 1]: Very weakly expressed in striated muscles and not detected in adult skeletal muscle fibers and cardiomyocytes. [Isoform 2]: Expressed in skeletal and cardiac muscles only (at protein level). Expressed at the submucosal mesenchyme and smooth muscle layer in the stomach and intestine at 16.5 dpc (at protein level). Expressed in the sinusoids in the liver, and Bowmans capsules and inter-renal tubule mesenchyme at 16.5 dpc (at protein level). Abundantly expressed in the smooth muscle layer of the lung at 16.5 dpc (at protein level). Abundantly expressed in the smooth muscle layer surrounding the trachea at 16.5 dpc (at protein level) (PubMed:22654117). Expression is down-regulated during myodifferentiation in culture (PubMed:8567725). [Isoform 2]: Not detected in proliferating myoblasts, but it appears immediately after myoblast fusion and its amount continues to rise during myotube growth and maturation reaching its highest level at day 9 through day 10, when mature differentiated myotubes appear in cell culture. The VWFA domain (or beta I domain) contains three cation- binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site. Isoform 2 knockout mice are viable and fertile, but male mice display a mild abnormality of cardiac function reflected by an increased expression of atrial natriuretic peptide and beta myosin heavy chain. Muscles do not show any histological or ultrastructural alterations. Replacement of isoform 1 by isoform 2 results in embryonic lethality before 16.5 dpc with a plethora of developmental defects including open neural tube, which is abnormally waved both rostrally and caudally. Some embryos lack part of the hindbrain and in most embryos the first branchial arch is shortened, which in some of the embryos leaves the tongue exposed. Abnormally strong fibronectin staining is seen in the mesenchyme under the open neural tube. Extravasation of red blood cells is evident in various tissues and they are also found in the pericardial cavity. Choroid plexus is virtually absent correlating with the presence of an abnormally smooth head and small brain cavities. At later developmental stages, a striking feature is the lack of a lower jaw and a dysmorphic lower face. These defects are in part caused by the abnormal migration of neuroepithelial cells. Belongs to the integrin beta chain family. Sequence=BAC36379.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; G1/S transition of mitotic cell cycle establishment of mitotic spindle orientation acrosomal vesicle in utero embryonic development cell fate specification ruffle tissue homeostasis fibronectin binding protease binding cell migration involved in sprouting angiogenesis actin binding receptor binding integrin binding protein binding collagen binding basement membrane cytoplasm endosome plasma membrane cell-cell junction adherens junction focal adhesion phagocytosis cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion calcium-independent cell-matrix adhesion integrin-mediated signaling pathway regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation integrin complex germ cell migration visual learning external side of plasma membrane cell surface regulation of collagen catabolic process positive regulation of cell-substrate adhesion positive regulation of neuron projection development intercalated disc membrane integral component of membrane cell migration kinase binding protein kinase binding protein domain specific binding C-X3-C chemokine binding formation of radial glial scaffolds lamellipodium cell projection organization lamellipodium assembly cell junction hemidesmosome filopodium positive regulation of cell migration neuron projection development negative regulation of cell projection organization cell-substrate adhesion neuromuscular junction receptor internalization ruffle membrane protein transport within lipid bilayer cell adhesion mediated by integrin cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion integrin alpha1-beta1 complex integrin alpha2-beta1 complex integrin alpha3-beta1 complex integrin alpha7-beta1 complex integrin alpha9-beta1 complex integrin alpha10-beta1 complex integrin alpha11-beta1 complex negative regulation of Rho protein signal transduction myelin sheath abaxonal region signaling receptor activity sarcolemma melanosome cell projection positive regulation of apoptotic process negative regulation of apoptotic process dendritic spine receptor complex laminin binding positive regulation of GTPase activity macromolecular complex binding membrane raft synapse postsynaptic membrane sarcomere organization negative regulation of cell differentiation negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of angiogenesis positive regulation of endocytosis metal ion binding protein heterodimerization activity mesodermal cell differentiation perinuclear region of cytoplasm axon extension cardiac muscle tissue development dendrite morphogenesis positive regulation of peptidyl-tyrosine phosphorylation modulation of synaptic transmission cell adhesion molecule binding leukocyte tethering or rolling alpha-actinin binding regulation of cell cycle positive regulation of protein kinase B signaling cardiac muscle cell differentiation recycling endosome bicellular tight junction assembly cellular response to low-density lipoprotein particle stimulus invadopodium membrane basement membrane organization synaptic membrane glial cell projection collagen binding involved in cell-matrix adhesion glutamatergic synapse integral component of postsynaptic membrane positive regulation of protein localization to plasma membrane positive regulation of receptor activity negative regulation of anoikis cytoplasmic vesicle transforming growth factor beta receptor signaling pathway stress fiber assembly uc009nzv.1 uc009nzv.2 uc009nzv.3 uc009nzv.4 
ENSMUST00000090019.10 Osbpl3 ENSMUST00000090019.10 oxysterol binding protein-like 3 (from RefSeq NM_001347213.1) D3YTT6 D3YTT6_MOUSE ENSMUST00000090019.1 ENSMUST00000090019.2 ENSMUST00000090019.3 ENSMUST00000090019.4 ENSMUST00000090019.5 ENSMUST00000090019.6 ENSMUST00000090019.7 ENSMUST00000090019.8 ENSMUST00000090019.9 NM_001347213 Osbpl3 uc057lqb.1 uc057lqb.2 uc057lqb.3 Belongs to the OSBP family. cytosol plasma membrane lipid transport cholesterol binding nuclear membrane perinuclear endoplasmic reticulum uc057lqb.1 uc057lqb.2 uc057lqb.3 
ENSMUST00000090020.13 Osbpl7 ENSMUST00000090020.13 oxysterol binding protein-like 7 (from RefSeq NM_001310509.2) A2A716 A2A716_MOUSE ENSMUST00000090020.1 ENSMUST00000090020.10 ENSMUST00000090020.11 ENSMUST00000090020.12 ENSMUST00000090020.2 ENSMUST00000090020.3 ENSMUST00000090020.4 ENSMUST00000090020.5 ENSMUST00000090020.6 ENSMUST00000090020.7 ENSMUST00000090020.8 ENSMUST00000090020.9 NM_001310509 Osbpl7 uc007ldo.1 uc007ldo.2 uc007ldo.3 uc007ldo.4 Belongs to the OSBP family. autophagosome cytosol plasma membrane lipid transport lipid binding cholesterol binding membrane sterol binding intracellular membrane-bounded organelle cellular response to cholesterol perinuclear endoplasmic reticulum positive regulation of proteasomal protein catabolic process uc007ldo.1 uc007ldo.2 uc007ldo.3 uc007ldo.4 
ENSMUST00000090023.13 Ap2m1 ENSMUST00000090023.13 adaptor-related protein complex 2, mu 1 subunit, transcript variant 2 (from RefSeq NM_001302970.1) Ap2m1 ENSMUST00000090023.1 ENSMUST00000090023.10 ENSMUST00000090023.11 ENSMUST00000090023.12 ENSMUST00000090023.2 ENSMUST00000090023.3 ENSMUST00000090023.4 ENSMUST00000090023.5 ENSMUST00000090023.6 ENSMUST00000090023.7 ENSMUST00000090023.8 ENSMUST00000090023.9 NM_001302970 Q3TWV4 Q3TWV4_MOUSE uc007ypy.1 uc007ypy.2 uc007ypy.3 uc007ypy.4 This gene encodes the mu subunit of the clathrin adaptor protein complex AP-2. It mediates sorting of cargo proteins harboring Y-X-X-Phi motifs into clathrin-coated vesicles. Alternate splicing of this gene results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2, 8 and 19. [provided by RefSeq, Dec 2014]. Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L- [LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. Cell membrane Membrane, coated pit ; Peripheral membrane protein ; Cytoplasmic side Belongs to the adaptor complexes medium subunit family. intracellular protein transport lipid binding protein transport membrane vesicle-mediated transport clathrin adaptor complex uc007ypy.1 uc007ypy.2 uc007ypy.3 uc007ypy.4 
ENSMUST00000090024.11 Ccser2 ENSMUST00000090024.11 coiled-coil serine rich 2, transcript variant 1 (from RefSeq NM_027045.1) B2RT11 CCSE2_MOUSE ENSMUST00000090024.1 ENSMUST00000090024.10 ENSMUST00000090024.2 ENSMUST00000090024.3 ENSMUST00000090024.4 ENSMUST00000090024.5 ENSMUST00000090024.6 ENSMUST00000090024.7 ENSMUST00000090024.8 ENSMUST00000090024.9 Fam190b Gcap14 Kiaa1128 NM_027045 Q2NKY3 Q3TA20 Q3UHI0 Q6ZPX3 Q9DAD5 uc007tbo.1 uc007tbo.2 uc007tbo.3 Microtubule-binding protein which might play a role in microtubule bundling. Cytoplasm, cytoskeleton Note=Associates with microtubules in interphase. Has diffuse expression throughout the cell during mitosis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UHI0-1; Sequence=Displayed; Name=2; IsoId=Q3UHI0-2; Sequence=VSP_029183; Expressed in brain (at protein level). Belongs to the CCSER family. Sequence=BAB24323.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; microtubule bundle formation cytoplasm cytoskeleton microtubule binding microtubule cytoskeleton uc007tbo.1 uc007tbo.2 uc007tbo.3 
ENSMUST00000090025.5 Aard ENSMUST00000090025.5 alanine and arginine rich domain containing protein (from RefSeq NM_175503.3) AARD_MOUSE ENSMUST00000090025.1 ENSMUST00000090025.2 ENSMUST00000090025.3 ENSMUST00000090025.4 NM_175503 Q811W1 Q8BL45 uc029spb.1 uc029spb.2 Preferentially expressed in testis both in embryo and adult. Expressed at much lower level in other tissues. Expressed early in testis differentiation specifically in Sertoli cells of the developing testis cords. molecular_function cellular_component biological_process lung development uc029spb.1 uc029spb.2 
ENSMUST00000090031.12 Gng5 ENSMUST00000090031.12 G protein subunit gamma 5 (from RefSeq NM_010318.2) ENSMUST00000090031.1 ENSMUST00000090031.10 ENSMUST00000090031.11 ENSMUST00000090031.2 ENSMUST00000090031.3 ENSMUST00000090031.4 ENSMUST00000090031.5 ENSMUST00000090031.6 ENSMUST00000090031.7 ENSMUST00000090031.8 ENSMUST00000090031.9 GBG5_MOUSE Gngt5 NM_010318 P30670 Q5I0W4 Q61015 Q80SZ7 uc008rrk.1 uc008rrk.2 uc008rrk.3 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units, alpha, beta and gamma. Cell membrane ; Lipid-anchor ; Cytoplasmic side Belongs to the G protein gamma family. GTPase activity mitochondrion heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane PDZ domain binding G-protein beta/gamma-subunit complex G-protein beta-subunit binding positive regulation of secondary heart field cardioblast proliferation positive regulation of neural precursor cell proliferation uc008rrk.1 uc008rrk.2 uc008rrk.3 
ENSMUST00000090042.12 Tmem87a ENSMUST00000090042.12 transmembrane protein 87A, transcript variant 3 (from RefSeq NM_001110497.1) A2AQJ5 A2AQJ5_MOUSE ENSMUST00000090042.1 ENSMUST00000090042.10 ENSMUST00000090042.11 ENSMUST00000090042.2 ENSMUST00000090042.3 ENSMUST00000090042.4 ENSMUST00000090042.5 ENSMUST00000090042.6 ENSMUST00000090042.7 ENSMUST00000090042.8 ENSMUST00000090042.9 NM_001110497 Tmem87a uc033hpr.1 uc033hpr.2 uc033hpr.3 Membrane ; Multi- pass membrane protein membrane integral component of membrane uc033hpr.1 uc033hpr.2 uc033hpr.3 
ENSMUST00000090061.6 Nup50l ENSMUST00000090061.6 nucleoporin 50 like (from RefSeq NR_003643.1) ENSMUST00000090061.1 ENSMUST00000090061.2 ENSMUST00000090061.3 ENSMUST00000090061.4 ENSMUST00000090061.5 NR_003643 Nup50l Q3V2K7 Q3V2K7_MOUSE uc009dag.1 uc009dag.2 uc009dag.3 Nucleus, nuclear pore complex nuclear pore protein import into nucleus intracellular transport uc009dag.1 uc009dag.2 uc009dag.3 
ENSMUST00000090070.6 Gimap4 ENSMUST00000090070.6 GTPase, IMAP family member 4, transcript variant 1 (from RefSeq NM_174990.4) D3YTN4 ENSMUST00000090070.1 ENSMUST00000090070.2 ENSMUST00000090070.3 ENSMUST00000090070.4 ENSMUST00000090070.5 GIMA4_MOUSE Ian1 Imap4 NM_174990 Q99JY3 uc009bvk.1 uc009bvk.2 uc009bvk.3 This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. This gene exists within a cluster of other related genes located on mouse chromosome 6. This family member encodes a lymphoid signaling protein that functions to accelerate programmed T-cell death, which appears to correlate with the phosphorylation status of the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]. During thymocyte development, may play a role in the regulation of apoptosis. Interacts (via IQ domain) with calmodulin/CALM1 only in the absence of Ca(2+) (PubMed:16569770). Interacts with BAX, but not with other Bcl-2 family members, including BAD, BAK1, BCL2, BCL2L1/Bcl-xL and BCL2L11/BimEL (PubMed:16509771). Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99JY3-1; Sequence=Displayed; Name=2; IsoId=Q99JY3-2; Sequence=VSP_060167, VSP_060168; Expressed in thymus (in thymocytes), spleen (in splenocytes), lymph node and lung (PubMed:16509771). Expressed in B- cells and T-cells (at protein level) (PubMed:16569770, PubMed:16509771). Up-regulated during T cell development, including upon the maturation of CD4/CD8 double-positive to CD4 single-positive thymocytes. Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation. Phosphorylation is increased in cells undergoing apoptosis. No visible phenotype. T-cell development, selection and activation in vivo appear to occur normally in knockout mice. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. nucleotide binding GTP binding cytoplasm cytosol uc009bvk.1 uc009bvk.2 uc009bvk.3 
ENSMUST00000090071.5 Pla2g4e ENSMUST00000090071.5 phospholipase A2, group IVE, transcript variant 1 (from RefSeq NM_177845.4) ENSMUST00000090071.1 ENSMUST00000090071.2 ENSMUST00000090071.3 ENSMUST00000090071.4 NM_177845 PA24E_MOUSE Q50L42 Q8BX44 uc008lvf.1 uc008lvf.2 Calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain (PubMed:27399000). Transfers the sn-1 fatty acyl chain of phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethanolamine (fatty acyl acceptor) to generate N-acyl phosphatidylethanolamine (NAPE). Similarly can use plasmenylethanolamine as a fatty acyl acceptor to form N-acyl plasmenylethanolamine (N-Acyl-PlsEt). Both NAPE and N-Acyl-PlsEt can serve as precursors of bioactive NAEs like N-arachidonoyl phosphatidylethanolamine also called anandamide (PubMed:27399000, PubMed:29447909). Has weak phospholipase A2 and lysophospholipase activities (PubMed:27399000, PubMed:15866882). Regulates intracellular membrane trafficking that requires modulation of membrane curvature as it occurs by enrichment in lysophospholipids. Promotes tubule formation involved in clathrin-independent endocytotic trafficking and cargo recycling (PubMed:24413173). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn- glycero-3-phosphoethanolamine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45188, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875, ChEBI:CHEBI:62537, ChEBI:CHEBI:64612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45189; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1- hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine = 2- octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2- di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:55252, ChEBI:CHEBI:15378, ChEBI:CHEBI:73000, ChEBI:CHEBI:74986, ChEBI:CHEBI:76076, ChEBI:CHEBI:78097; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55253; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1- octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2- di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:55248, ChEBI:CHEBI:15378, ChEBI:CHEBI:74986, ChEBI:CHEBI:75026, ChEBI:CHEBI:76078, ChEBI:CHEBI:85292; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55249; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn- glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45172, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:76078, ChEBI:CHEBI:78097; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45173; Evidence=; Reaction=1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3- phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero- 3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di- (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:55256, ChEBI:CHEBI:15378, ChEBI:CHEBI:60657, ChEBI:CHEBI:74986, ChEBI:CHEBI:76079, ChEBI:CHEBI:85277; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55257; Evidence=; Reaction=2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2- tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:55260, ChEBI:CHEBI:15378, ChEBI:CHEBI:74986, ChEBI:CHEBI:76088, ChEBI:CHEBI:85291; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55261; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z- octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N- hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:63592, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:76078, ChEBI:CHEBI:78340, ChEBI:CHEBI:138663; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63593; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= Stimulated by cytosolic Ca(2+) (PubMed:27399000, PubMed:29447909). Stimulated by anionic phospholipids such as phosphatidylserine (PubMed:29447909). pH dependence: Optimum pH is 8. ; Cytoplasm, cytosol Early endosome membrane eripheral membrane protein ; Cytoplasmic side Lysosome membrane eripheral membrane protein ; Cytoplasmic side Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Targeted to clathrin-independent endocytotic vesicles through binding to phosphoinositides, especially phosphatidylinositol 4,5-bisphosphates. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q50L42-1; Sequence=Displayed; Name=2; IsoId=Q50L42-2; Sequence=VSP_019884, VSP_019885, VSP_019886; Predominantly expressed in brain, heart, skeletal muscle, testis and thyroid (PubMed:15866882, PubMed:27399000). Expressed in neurons but not astrocytes or microglia (PubMed:27399000). Expressed at lower level in stomach (PubMed:15866882). The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity). phospholipase activity phospholipase A2 activity calcium ion binding calcium-dependent phospholipid binding cytoplasm lysosome lysosomal membrane cytosol lipid metabolic process phospholipid catabolic process membrane lipid catabolic process hydrolase activity glycerophospholipid catabolic process metal ion binding calcium-dependent phospholipase A2 activity uc008lvf.1 uc008lvf.2 
ENSMUST00000090086.11 Gnb1l ENSMUST00000090086.11 guanine nucleotide binding protein (G protein), beta polypeptide 1-like, transcript variant 2 (from RefSeq NM_023120.5) ENSMUST00000090086.1 ENSMUST00000090086.10 ENSMUST00000090086.2 ENSMUST00000090086.3 ENSMUST00000090086.4 ENSMUST00000090086.5 ENSMUST00000090086.6 ENSMUST00000090086.7 ENSMUST00000090086.8 ENSMUST00000090086.9 Estm55 GNB1L_MOUSE NM_023120 Q8R1F3 Q9CWP2 Q9D3Y1 Q9EQ15 Wdr14 uc007yod.1 uc007yod.2 uc007yod.3 uc007yod.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EQ15-1; Sequence=Displayed; Name=2; IsoId=Q9EQ15-2; Sequence=VSP_006769, VSP_006770; Expressed at low levels in most tissues and highly expressed in adult testis. Sequence=BAB26980.1; Type=Frameshift; Evidence=; molecular_function cytoplasm social behavior uc007yod.1 uc007yod.2 uc007yod.3 uc007yod.4 
ENSMUST00000090127.7 Gbp5 ENSMUST00000090127.7 guanylate binding protein 5 (from RefSeq NM_153564.2) E9QJR4 ENSMUST00000090127.1 ENSMUST00000090127.2 ENSMUST00000090127.3 ENSMUST00000090127.4 ENSMUST00000090127.5 ENSMUST00000090127.6 GBP5_MOUSE Gbp5 NM_153564 Q8CFA4 Q8CFA8 Q8CFB4 uc008rop.1 uc008rop.2 uc008rop.3 Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:22461501, PubMed:24739961, PubMed:24715728, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30589883). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24739961, PubMed:24715728, PubMed:25774715, PubMed:25774716). Acts by promoting lysis of pathogen- containing vacuoles, releasing pathogens into the cytosol (PubMed:24739961, PubMed:24715728, PubMed:25774715, PubMed:25774716). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24739961, PubMed:24715728, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30589883). As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity by inhibiting FURIN- mediated maturation of viral envelope proteins (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Homodimer; homodimerizes upon GTP-binding, forming a close face-to-face dimer. Heterodimer with other family members, including GBP1, GBP2, GBP3 and GBP4. May also form tetramers (dimer of dimers) in the presence of GTP. Interacts with NLRP3, possibly in its tetrameric form, and promotes PYCARD/ASC polymerization. Cytoplasmic vesicle membrane ; Lipid-anchor Golgi apparatus membrane ; Lipid-anchor Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CFB4-1; Sequence=Displayed; Name=2; Synonyms=GBP-5a; IsoId=Q8CFB4-2; Sequence=VSP_057889, VSP_057890; Low expression, if any, in many tissues in the absence of stimulation. Strongly up-regulated by IFNG and, at lower levels, by LPS. The LPS-induced increase is attenuated in the presence of dexamethasone (PubMed:12396730, PubMed:18025219). Up-regulated by TNF in certain strains (PubMed:12396730). Up-regulation by a combination of IFNG and TNF is synergistic, even in strains that do not respond to TNF alone (PubMed:12396730). By IRF1 in response to bacterial infection (PubMed:25774715). Isoprenylation is required for proper subcellular location. Mutant mice exhibit impaired host defense and NLRP3-dependent inflammatory responses. During LPS-induced sepsis, knockout animals show 60 to 75% reduction in IL1B and IL-18 serum levels compared to wild-type mice. Orogastric challenge with Listeria monocytogenes leads to higher bacterial burdens, discernible weight loss, and 50 to 80% fewer leukocytes expressing active CASP1 in mesenteric lymph nodes compared to wild-type counterparts. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily. Golgi membrane nucleotide binding immune system process GTPase activity protein binding GTP binding cytoplasm Golgi apparatus inflammatory response response to bacterium membrane hydrolase activity cytoplasmic vesicle protein localization to Golgi apparatus identical protein binding protein homodimerization activity positive regulation of innate immune response perinuclear region of cytoplasm interleukin-1 beta secretion protein homotetramerization cellular response to interferon-gamma interleukin-18 secretion positive regulation of cytokine production involved in inflammatory response positive regulation of NLRP3 inflammasome complex assembly uc008rop.1 uc008rop.2 uc008rop.3 
ENSMUST00000090147.7 Btd ENSMUST00000090147.7 biotinidase, transcript variant 1 (from RefSeq NM_025295.4) A0A0R4J131 A0A0R4J131_MOUSE Btd ENSMUST00000090147.1 ENSMUST00000090147.2 ENSMUST00000090147.3 ENSMUST00000090147.4 ENSMUST00000090147.5 ENSMUST00000090147.6 NM_025295 uc007sxy.1 uc007sxy.2 uc007sxy.3 uc007sxy.4 Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. nitrogen compound metabolic process hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides uc007sxy.1 uc007sxy.2 uc007sxy.3 uc007sxy.4 
ENSMUST00000090150.11 Ncald ENSMUST00000090150.11 neurocalcin delta, transcript variant 1 (from RefSeq NM_134094.4) D15Ertd412e ENSMUST00000090150.1 ENSMUST00000090150.10 ENSMUST00000090150.2 ENSMUST00000090150.3 ENSMUST00000090150.4 ENSMUST00000090150.5 ENSMUST00000090150.6 ENSMUST00000090150.7 ENSMUST00000090150.8 ENSMUST00000090150.9 NCALD_MOUSE NM_134094 Q3TJS9 Q8BZN9 Q91X97 uc007vni.1 uc007vni.2 uc007vni.3 uc007vni.4 May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). Interacts with GUCY2D. Belongs to the recoverin family. regulation of systemic arterial blood pressure actin binding calcium ion binding cytosol tubulin binding calcium-mediated signaling clathrin binding alpha-tubulin binding metal ion binding uc007vni.1 uc007vni.2 uc007vni.3 uc007vni.4 
ENSMUST00000090171.7 Adh7 ENSMUST00000090171.7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (from RefSeq NM_009626.4) Adh4 Adh7 ENSMUST00000090171.1 ENSMUST00000090171.2 ENSMUST00000090171.3 ENSMUST00000090171.4 ENSMUST00000090171.5 ENSMUST00000090171.6 NM_009626 Q9D748 Q9D748_MOUSE uc008rnd.1 uc008rnd.2 uc008rnd.3 uc008rnd.4 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Cytoplasm Belongs to the zinc-containing alcohol dehydrogenase family. retinoid metabolic process alcohol dehydrogenase activity, zinc-dependent aldehyde oxidase activity retinol dehydrogenase activity cytosol plasma membrane ethanol oxidation zinc ion binding response to bacterium fatty acid omega-oxidation oxidoreductase activity retinol binding ethanol binding response to ethanol metal ion binding receptor antagonist activity oxidation-reduction process negative regulation of receptor activity uc008rnd.1 uc008rnd.2 uc008rnd.3 uc008rnd.4 
ENSMUST00000090174.11 Zfyve19 ENSMUST00000090174.11 zinc finger, FYVE domain containing 19, transcript variant 1 (from RefSeq NM_028054.3) A2AV55 ANCHR_MOUSE Anchr ENSMUST00000090174.1 ENSMUST00000090174.10 ENSMUST00000090174.2 ENSMUST00000090174.3 ENSMUST00000090174.4 ENSMUST00000090174.5 ENSMUST00000090174.6 ENSMUST00000090174.7 ENSMUST00000090174.8 ENSMUST00000090174.9 NM_028054 Q8VCV7 Q9DAZ9 uc008lti.1 uc008lti.2 uc008lti.3 uc008lti.4 Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission (By similarity). Interacts (via MIM1-B) with VPS4A; interaction takes place at the midbody ring following cytokinesis checkpoint activation. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cleavage furrow Midbody, Midbody ring Note=Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis. The FYVE-type zinc finger mediates binding to phosphatidylinositol-3-phosphate (PtdIns(3)P). The MIM1-B motif mediates interaction with VPS4A. cytoplasm centrosome microtubule organizing center cytoskeleton cell cycle lipid binding abscission midbody cleavage furrow phosphatidylinositol-3-phosphate binding negative regulation of cytokinesis mitotic cytokinesis checkpoint metal ion binding cell division Flemming body uc008lti.1 uc008lti.2 uc008lti.3 uc008lti.4 
ENSMUST00000090178.10 Dnajb14 ENSMUST00000090178.10 DnaJ heat shock protein family (Hsp40) member B14 (from RefSeq NM_001033155.1) DJB14_MOUSE Dnajb14 ENSMUST00000090178.1 ENSMUST00000090178.2 ENSMUST00000090178.3 ENSMUST00000090178.4 ENSMUST00000090178.5 ENSMUST00000090178.6 ENSMUST00000090178.7 ENSMUST00000090178.8 ENSMUST00000090178.9 NM_001033155 Q149L6 Q3TU54 Q3UTE5 uc008rmr.1 uc008rmr.2 uc008rmr.3 uc008rmr.4 Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum- associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear. Interacts (via J domain) with HSPA8/Hsc70. Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct. Endoplasmic reticulum membrane ; Single-pass membrane protein Nucleus membrane ; Single- pass membrane protein Note=Localizes to the endoplasmic reticulum membrane. When overexpressed, forms membranous structures in the nucleus. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q149L6-1; Sequence=Displayed; Name=2; IsoId=Q149L6-2; Sequence=VSP_024008; Name=3; IsoId=Q149L6-3; Sequence=VSP_024009, VSP_024010; Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily. nucleus endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane ER-associated ubiquitin-dependent protein catabolic process Hsp70 protein binding nuclear membrane cellular macromolecular complex assembly chaperone mediated protein folding requiring cofactor cellular response to misfolded protein uc008rmr.1 uc008rmr.2 uc008rmr.3 uc008rmr.4 
ENSMUST00000090180.4 Sema3g ENSMUST00000090180.4 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G (from RefSeq NM_001025379.1) ENSMUST00000090180.1 ENSMUST00000090180.2 ENSMUST00000090180.3 NM_001025379 Q3UVA7 Q4LFA9 SEM3G_MOUSE uc007sxe.1 uc007sxe.2 uc007sxe.3 Has chemorepulsive activities for sympathetic axons. Ligand of NRP2. Secreted. Highly expressed in lung and kidney. Weakly expressed in brain. Belongs to the semaphorin family. neural crest cell migration receptor binding extracellular region extracellular space integral component of plasma membrane semaphorin receptor binding positive regulation of cell migration negative regulation of axon extension chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway uc007sxe.1 uc007sxe.2 uc007sxe.3 
ENSMUST00000090190.14 Hic2 ENSMUST00000090190.14 hypermethylated in cancer 2 (from RefSeq NM_178922.3) ENSMUST00000090190.1 ENSMUST00000090190.10 ENSMUST00000090190.11 ENSMUST00000090190.12 ENSMUST00000090190.13 ENSMUST00000090190.2 ENSMUST00000090190.3 ENSMUST00000090190.4 ENSMUST00000090190.5 ENSMUST00000090190.6 ENSMUST00000090190.7 ENSMUST00000090190.8 ENSMUST00000090190.9 HIC2_MOUSE Kiaa1020 NM_178922 Q3U030 Q3ULP4 Q5K036 Q8BSZ9 Q8C3T5 Q9JLZ6 uc007yko.1 uc007yko.2 uc007yko.3 Transcriptional repressor. Self-associates. Interacts with HIC1 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JLZ6-1; Sequence=Displayed; Name=2; IsoId=Q9JLZ6-2; Sequence=VSP_010499; Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily. Sequence=BAC98076.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAI30631.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; nucleic acid binding DNA binding nucleus cellular response to DNA damage stimulus protein C-terminus binding metal ion binding uc007yko.1 uc007yko.2 uc007yko.3 
ENSMUST00000090227.6 Marchf6 ENSMUST00000090227.6 membrane associated ring-CH-type finger 6, transcript variant 1 (from RefSeq NM_172606.3) ENSMUST00000090227.1 ENSMUST00000090227.2 ENSMUST00000090227.3 ENSMUST00000090227.4 ENSMUST00000090227.5 Kiaa0597 MARH6_MOUSE March6 NM_172606 Q6PCS1 Q6ZQ89 Q80V02 Q80VC7 Q8BJA0 Q8BXX6 uc007vkh.1 uc007vkh.2 uc007vkh.3 E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with DIO2. Interacts with SQLE. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6ZQ89-1; Sequence=Displayed; Name=2; IsoId=Q6ZQ89-2; Sequence=VSP_022702, VSP_022703; Name=3; IsoId=Q6ZQ89-3; Sequence=VSP_022704; The RING-CH-type zinc finger domain is required for E3 ligase activity. Auto-ubiquitinated, which results in proteasomal degradation. Belongs to the DOA10/MARCHF6 family. Sequence=AAH37454.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; ubiquitin-protein transferase activity endoplasmic reticulum endoplasmic reticulum membrane zinc ion binding proteasomal protein catabolic process membrane integral component of membrane protein ubiquitination transferase activity enzyme binding integral component of endoplasmic reticulum membrane ER-associated ubiquitin-dependent protein catabolic process ubiquitin conjugating enzyme binding proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity protein K48-linked ubiquitination ubiquitin-specific protease binding uc007vkh.1 uc007vkh.2 uc007vkh.3 
ENSMUST00000090243.8 Slc37a3 ENSMUST00000090243.8 solute carrier family 37 (glycerol-3-phosphate transporter), member 3, transcript variant 2 (from RefSeq NM_028123.3) A0A0R4J133 A0A0R4J133_MOUSE ENSMUST00000090243.1 ENSMUST00000090243.2 ENSMUST00000090243.3 ENSMUST00000090243.4 ENSMUST00000090243.5 ENSMUST00000090243.6 ENSMUST00000090243.7 NM_028123 Slc37a3 uc009bll.1 uc009bll.2 uc009bll.3 uc009bll.4 uc009bll.5 Lysosome membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. integral component of plasma membrane membrane integral component of membrane transmembrane transporter activity transmembrane transport uc009bll.1 uc009bll.2 uc009bll.3 uc009bll.4 uc009bll.5 
ENSMUST00000090246.5 Sgms2 ENSMUST00000090246.5 sphingomyelin synthase 2, transcript variant 2 (from RefSeq NM_028943.6) ENSMUST00000090246.1 ENSMUST00000090246.2 ENSMUST00000090246.3 ENSMUST00000090246.4 NM_028943 Q149I0 Q9D4B1 SMS2_MOUSE uc008rjq.1 uc008rjq.2 uc008rjq.3 uc008rjq.4 uc008rjq.5 Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. [provided by RefSeq, Oct 2008]. Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane (PubMed:19590047, PubMed:21844222, PubMed:22580896). Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by- product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction appears to depend on the levels of CER and DAG in the plasma membrane. Does not use free phosphorylcholine or CDP-choline as donors (By similarity). Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to ceramide (CER) to form ceramide phosphoethanolamine (CPE) (By similarity). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:19590047, PubMed:21844222). To a lesser extent, plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1. Required for normal bone matrix mineralization (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4- enine = a 1,2-diacyl-sn-glycerol + a sphingomyelin; Xref=Rhea:RHEA:18765, ChEBI:CHEBI:17636, ChEBI:CHEBI:17815, ChEBI:CHEBI:52639, ChEBI:CHEBI:57643; EC=2.7.8.27; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18766; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18767; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N- acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin; Xref=Rhea:RHEA:43324, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:72999, ChEBI:CHEBI:82929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43325; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:43326; Evidence=; Reaction=1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N- acylsphing-4-enine; Xref=Rhea:RHEA:43320, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:78421, ChEBI:CHEBI:82983; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43321; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:43322; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + N- hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl- sphinganine-1-phosphocholine; Xref=Rhea:RHEA:41796, ChEBI:CHEBI:17815, ChEBI:CHEBI:57643, ChEBI:CHEBI:67042, ChEBI:CHEBI:78647; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41797; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:41798; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl- (4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl- (4R)-hydroxysphinganine-phosphocholine; Xref=Rhea:RHEA:42140, ChEBI:CHEBI:17815, ChEBI:CHEBI:57643, ChEBI:CHEBI:65107, ChEBI:CHEBI:78650; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42141; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42142; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N- hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl- sphinganine-1-phosphoethanolamine; Xref=Rhea:RHEA:42128, ChEBI:CHEBI:17815, ChEBI:CHEBI:64612, ChEBI:CHEBI:67042, ChEBI:CHEBI:78654; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42129; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N- hexadecanoyl-(4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N- hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine; Xref=Rhea:RHEA:42144, ChEBI:CHEBI:17815, ChEBI:CHEBI:64612, ChEBI:CHEBI:65107, ChEBI:CHEBI:78656; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42145; Evidence=; Sphingolipid metabolism. Cell membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Note=Primarily localized at the plasma membrane with a small fraction at the Golgi apparatus. Highest expression is detected in cortical bone, followed by vertebrae, kidney and liver. Expression levels are very low in spleen, muscle, heart, brown fat and thymus (PubMed:30779713). Expressed in macrophages. Palmitoylated on Cys-331, Cys-332, Cys-343 and Cys-348; which plays an important role in plasma membrane localization. Null mice are viable but exhibit increased cell membrane ceramide and decreased sphingomyelin levels. In both skeletal muscle and adipose tissue, there is a significant increase in glucose uptake. This leads to increased insulin sensitivity and ameliorated high-fat diet-induced obesity. There is blunted NFKB1- and MAP kinase- mediated responses to inflammatory stimuli and macrophages display increased cholesterol efflux into blood circulation. Liver SMS activity is markedly reduced (by about 80%) but only small change in macrophage SMS2 activity (16%). No change in glycosphingolipid levels in plasma. Atherosclerosis in SMS2(-/-)/LDLR(-/-) mice is significantly decreased. Belongs to the sphingomyelin synthase family. Golgi membrane ceramide phosphoethanolamine synthase activity Golgi apparatus plasma membrane integral component of plasma membrane lipid metabolic process sphingolipid metabolic process sphingomyelin biosynthetic process membrane integral component of membrane kinase activity phosphorylation transferase activity sphingolipid biosynthetic process integral component of Golgi membrane integral component of endoplasmic reticulum membrane sphingomyelin synthase activity ceramide biosynthetic process ceramide cholinephosphotransferase activity ceramide phosphoethanolamine biosynthetic process uc008rjq.1 uc008rjq.2 uc008rjq.3 uc008rjq.4 uc008rjq.5 
ENSMUST00000090247.7 Trio ENSMUST00000090247.7 triple functional domain (PTPRF interacting) (from RefSeq NM_001081302.1) ENSMUST00000090247.1 ENSMUST00000090247.2 ENSMUST00000090247.3 ENSMUST00000090247.4 ENSMUST00000090247.5 ENSMUST00000090247.6 NM_001081302 Q0KL02 Q3U522 Q6P9K6 Q80W23 TRIO_MOUSE uc007vjw.1 uc007vjw.2 uc007vjw.3 Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth (By similarity). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (By similarity). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (PubMed:22666460). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts with CARMIL1. Interacts with PTPRF/LAR. Interacts with ANKRD26 (By similarity). Interacts with Bassoon/BSN and Piccolo/PCLO (By similarity). Interacts with the cytoplasmic region of the heterodimer formed by NGFR and SORCS2. ProNGF binding mediates dissociation of TRIO from the receptor complex (By similarity). Cytoplasm Cell projection [Isoform 2]: Early endosome Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q0KL02-1; Sequence=Displayed; Name=2; IsoId=Q0KL02-2; Sequence=VSP_023308, VSP_023309; Name=3; IsoId=Q0KL02-3; Sequence=VSP_037863, VSP_037864, VSP_037865; Name=4; IsoId=Q0KL02-4; Sequence=VSP_037863; Widespread in the brain, with more intense signals in the hippocampus, olfactory bulb, cortical layers and cerebellum. Isoform 2 is predominantly expressed in Purkinje neurons of brain. The N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Sequence=BAE32258.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity ATP binding cytoplasm endosome early endosome protein phosphorylation axon guidance central nervous system development kinase activity phosphorylation transferase activity enzyme binding regulation of Rho protein signal transduction cell projection negative regulation of fat cell differentiation uc007vjw.1 uc007vjw.2 uc007vjw.3 
ENSMUST00000090260.6 Gm4841 ENSMUST00000090260.6 predicted gene 4841 (from RefSeq NM_001034859.3) E9QAA8 E9QAA8_MOUSE ENSMUST00000090260.1 ENSMUST00000090260.2 ENSMUST00000090260.3 ENSMUST00000090260.4 ENSMUST00000090260.5 Gm4841 Ifgga3 NM_001034859 uc012bdk.1 uc012bdk.2 uc012bdk.3 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. GTPase activity GTP binding endoplasmic reticulum membrane defense response membrane cellular response to interferon-beta uc012bdk.1 uc012bdk.2 uc012bdk.3 
ENSMUST00000090269.7 Actc1 ENSMUST00000090269.7 actin, alpha, cardiac muscle 1 (from RefSeq NM_009608.4) Actc1 ENSMUST00000090269.1 ENSMUST00000090269.2 ENSMUST00000090269.3 ENSMUST00000090269.4 ENSMUST00000090269.5 ENSMUST00000090269.6 NM_009608 Q497E4 Q497E4_MOUSE uc008lpz.1 uc008lpz.2 uc008lpz.3 uc008lpz.4 uc008lpz.5 Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family. nucleotide binding ATP binding cytoplasm cytoskeleton actin filament positive regulation of gene expression ATPase activity myosin binding sarcomere lamellipodium actin filament-based movement filopodium actin-myosin filament sliding response to drug actomyosin, actin portion cell body response to ethanol heart contraction cardiac muscle contraction mesenchyme migration uc008lpz.1 uc008lpz.2 uc008lpz.3 uc008lpz.4 uc008lpz.5 
ENSMUST00000090275.5 Gjd2 ENSMUST00000090275.5 gap junction protein, delta 2, transcript variant 1 (from RefSeq NM_010290.3) CXD2_MOUSE ENSMUST00000090275.1 ENSMUST00000090275.2 ENSMUST00000090275.3 ENSMUST00000090275.4 Gja9 NM_010290 O54851 Q6PDP3 Q9JII0 uc008lpu.1 uc008lpu.2 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Highly expressed in neurons. Belongs to the connexin family. Delta-type subfamily. action potential protein binding plasma membrane gap junction connexin complex cell communication cell-cell signaling chemical synaptic transmission visual perception membrane integral component of membrane cell junction uc008lpu.1 uc008lpu.2 
ENSMUST00000090277.3 Clxn ENSMUST00000090277.3 calaxin (from RefSeq NM_025769.3) CLXN_MOUSE ENSMUST00000090277.1 ENSMUST00000090277.2 Efcab1 NM_025769 Q8BSW3 Q8C982 Q8CAI0 Q9D3N2 Q9D527 Q9D5E7 uc007yhn.1 uc007yhn.2 uc007yhn.3 Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Seems to regulate the assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). Regulates ciliary and flagellar motility and is required for cilia- driven determination of body laterality (PubMed:31240264). Component of the outer dynein arm-docking complex along with ODAD1, ODAD2, ODAD3 and ODAD4. Cytoplasm, cytoskeleton, cilium axoneme Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9D3N2-1; Sequence=Displayed; Name=2; IsoId=Q9D3N2-2; Sequence=VSP_020830, VSP_020831; Name=3; IsoId=Q9D3N2-3; Sequence=VSP_020828, VSP_020829; Name=4; IsoId=Q9D3N2-4; Sequence=VSP_020827; Mice display typical phenotypes of primary ciliary dyskinesia, including hydrocephalus, situs inversus, and abnormal motility of trachea cilia and sperm flagella (PubMed:31240264). Strikingly, both males and females are viable and fertile (PubMed:31240264). The 9 + 2 axonemal structures of epithelial multicilia and sperm flagella are normal, but the formation of 9 + 0 nodal cilia is significantly disrupted (PubMed:31240264). calcium ion binding axoneme dynein heavy chain binding metal ion binding beta-tubulin binding cell chemotaxis 9+2 motile cilium regulation of flagellated sperm motility negative regulation of ATP-dependent microtubule motor activity, minus-end-directed uc007yhn.1 uc007yhn.2 uc007yhn.3 
ENSMUST00000090287.5 Myh11 ENSMUST00000090287.5 myosin, heavy polypeptide 11, smooth muscle, transcript variant 2 (from RefSeq NM_001161775.2) E9QPE7 E9QPE7_MOUSE ENSMUST00000090287.1 ENSMUST00000090287.2 ENSMUST00000090287.3 ENSMUST00000090287.4 Myh11 NM_001161775 uc007yhe.1 uc007yhe.2 uc007yhe.3 uc007yhe.4 Muscle contraction. Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. nucleotide binding motor activity actin binding ATP binding myosin complex actin filament binding uc007yhe.1 uc007yhe.2 uc007yhe.3 uc007yhe.4 
ENSMUST00000090300.6 Marf1 ENSMUST00000090300.6 meiosis regulator and mRNA stability 1 (from RefSeq NM_001081154.2) E9QPE4 ENSMUST00000090300.1 ENSMUST00000090300.2 ENSMUST00000090300.3 ENSMUST00000090300.4 ENSMUST00000090300.5 Kiaa0430 Lkap MARF1_MOUSE NM_001081154 Q5DU29 Q8BJ34 Q8C6U4 Q8K2E6 uc007ygv.1 uc007ygv.2 uc007ygv.3 uc007ygv.4 Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks. Interacts with LIMK2. Peroxisome Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8BJ34-1; Sequence=Displayed; Name=2; IsoId=Q8BJ34-2; Sequence=VSP_022992, VSP_022993, VSP_022997, VSP_022999; Name=3; IsoId=Q8BJ34-3; Sequence=VSP_022992, VSP_022994, VSP_022995, VSP_022996, VSP_022997; Name=4; IsoId=Q8BJ34-4; Sequence=VSP_023002; Name=5; IsoId=Q8BJ34-5; Sequence=VSP_022991, VSP_022998, VSP_023000, VSP_023001; Name=6; IsoId=Q8BJ34-6; Sequence=VSP_022997, VSP_022998, VSP_023002; Predominantly present in oocytes and barely detectable in granulosa cells (at protein level). Detected in germ cells in quiescent oocytes isolated from newborn P0 ovaries that have not yet commenced the growth phase. Protein levels increase after oocytes initiate growth, and follicular development reach the primary follicle stage at P6. Thereafter, protein levels remain at the similar levels (at protein level). Female infertility due to oocyte meiotic arrest at the germinal vesicle stage: ovaries look normal, but oocytes do not resume meiosis even after a superovulatory regimen of gonadotropins and are ovulated at the immature germinal vesicle stage. Oocytes display strong up-regulation of a transcripts, increased retrotransposon expression, defective cytoplasmic maturation, and meiotic arrest. Mutant males are fertile. Sequence=BAD90407.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function nucleic acid binding RNA binding peroxisome Golgi apparatus double-strand break repair female meiotic division regulation of gene expression negative regulation of phosphatase activity cell differentiation intracellular membrane-bounded organelle oogenesis meiotic cell cycle uc007ygv.1 uc007ygv.2 uc007ygv.3 uc007ygv.4 
ENSMUST00000090313.5 Dytn ENSMUST00000090313.5 dystrotelin (from RefSeq NM_001081658.1) A2CI98 DYTN_MOUSE ENSMUST00000090313.1 ENSMUST00000090313.2 ENSMUST00000090313.3 ENSMUST00000090313.4 Gm215 NM_001081658 Q5F254 uc007bgi.1 uc007bgi.2 Cell membrane Strongly expressed in the nervous and muscular tissues. At 10.5 dpc, expressed largely in the brain and neural tube. molecular_function cellular_component plasma membrane biological_process zinc ion binding membrane metal ion binding uc007bgi.1 uc007bgi.2 
ENSMUST00000090329.2 Or4g16 ENSMUST00000090329.2 olfactory receptor family 4 subfamily G member 16 (from RefSeq NM_146393.1) ENSMUST00000090329.1 NM_146393 Olfr1279 Or4g16 Q8VF38 Q8VF38_MOUSE uc008lng.1 uc008lng.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC113137.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008lng.1 uc008lng.2 
ENSMUST00000090379.7 Usp53 ENSMUST00000090379.7 ubiquitin specific peptidase 53, transcript variant 2 (from RefSeq NM_133857.4) A2RT25 ENSMUST00000090379.1 ENSMUST00000090379.2 ENSMUST00000090379.3 ENSMUST00000090379.4 ENSMUST00000090379.5 ENSMUST00000090379.6 NM_133857 P15975 Phxr3 Q8BR11 Q8CB37 Q8R251 UBP53_MOUSE Usp53 uc008rez.1 uc008rez.2 uc008rez.3 Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (PubMed:26609154). Has no peptidase activity (PubMed:26609154). Interacts (via the C-terminal region) with the heterodimer TJP1:TJP2. Cell junction, tight junction Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P15975-1; Sequence=Displayed; Name=2; IsoId=P15975-2; Sequence=VSP_058590, VSP_058591; Expressed in the cochlea. Isoform 1 expression levels are 10-fold higher than isoform 2 expression levels. Expressed in the liver. Belongs to the peptidase C19 family. Although the active site residues are conserved, lacks the conserved His residue which is normally found 9 residues before the catalytic His. Sequence=CAA31296.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence=; action potential protein binding cell-cell junction bicellular tight junction proteolysis apoptotic process sensory perception of sound response to auditory stimulus cell junction neuron apoptotic process protein deubiquitination thiol-dependent ubiquitinyl hydrolase activity ubiquitinyl hydrolase activity uc008rez.1 uc008rez.2 uc008rez.3 
ENSMUST00000090398.11 Dlg5 ENSMUST00000090398.11 discs large MAGUK scaffold protein 5, transcript variant 1 (from RefSeq NM_001163513.1) DLG5_MOUSE E9Q9R9 ENSMUST00000090398.1 ENSMUST00000090398.10 ENSMUST00000090398.2 ENSMUST00000090398.3 ENSMUST00000090398.4 ENSMUST00000090398.5 ENSMUST00000090398.6 ENSMUST00000090398.7 ENSMUST00000090398.8 ENSMUST00000090398.9 NM_001163513 Q3UGX5 uc007sqg.1 uc007sqg.2 uc007sqg.3 Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (By similarity). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin (PubMed:25232112). Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (PubMed:25644602). Interacts with MPP1. Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex (By similarity). Interacts (via coiled-coil domain) with MARK3. Interacts (via PDZ domain 3) with STK3/MST2 and STK4/MST1 (PubMed:28087714). Interacts with SCRIB (By similarity). Interacts with CTNB1 (PubMed:25232112). Interacts with SMO and (via PDZ4 or guanylate kinase-like domain) with KIF7 (PubMed:25644602). Cell junction Cell membrane ; Peripheral membrane protein Postsynaptic density Cytoplasm, cytoskeleton, cilium basal body Note=Localized at sites of cell- cell contact. Brain (at protein level). The guanylate kinase-like domain interacts with the SH3 domain. Belongs to the MAGUK family. epithelial to mesenchymal transition protein binding cytoplasm cytoskeleton plasma membrane cell-cell adherens junction beta-catenin binding cytoskeletal protein binding postsynaptic density membrane maintenance of cell polarity cell junction negative regulation of cell migration polarized epithelial cell differentiation midbrain development negative regulation of hippo signaling positive regulation of hippo signaling ciliary basal body negative regulation of T cell proliferation regulation of apoptotic process cell projection apical protein localization zonula adherens assembly establishment or maintenance of epithelial cell apical/basal polarity synapse postsynaptic membrane positive regulation of smoothened signaling pathway positive regulation of synapse assembly epithelial tube branching involved in lung morphogenesis positive regulation of dendritic spine development macromolecular complex assembly protein localization to adherens junction metanephric collecting duct development uc007sqg.1 uc007sqg.2 uc007sqg.3 
ENSMUST00000090413.6 Utp3 ENSMUST00000090413.6 UTP3 small subunit processome component (from RefSeq NM_023054.2) Crl1 Crlz1 ENSMUST00000090413.1 ENSMUST00000090413.2 ENSMUST00000090413.3 ENSMUST00000090413.4 ENSMUST00000090413.5 NM_023054 Q3UL95 Q8R5C6 Q9JI13 Q9JJ12 SAS10_MOUSE Sas10 uc008xzv.1 uc008xzv.2 uc008xzv.3 Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q9JI13-1; Sequence=Displayed; Name=2 ; IsoId=Q9JI13-2; Sequence=VSP_051655, VSP_051656; Detected mainly in subsets of neuronal cells of the brain. In the 17.5 dpc embryo, mainly expressed in the olfactory bulb and cerebral cortex. Postnatally, additionally expressed in the cerebellar cortex, most strongly in the hippocampus. Expressed throughout development. Citrullinated by PADI4. Belongs to the SAS10 family. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) protein binding nucleus nucleolus chromatin organization multicellular organism development brain development small-subunit processome uc008xzv.1 uc008xzv.2 uc008xzv.3 
ENSMUST00000090414.11 Stk33 ENSMUST00000090414.11 Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME. (from UniProt Q924X7) AK014819 ENSMUST00000090414.1 ENSMUST00000090414.10 ENSMUST00000090414.2 ENSMUST00000090414.3 ENSMUST00000090414.4 ENSMUST00000090414.5 ENSMUST00000090414.6 ENSMUST00000090414.7 ENSMUST00000090414.8 ENSMUST00000090414.9 Q4A1D4 Q924X7 STK33_MOUSE uc291uio.1 uc291uio.2 Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts with VIME. Cytoplasm, perinuclear region Highly expressed in testis, particularly in cells from the spermatogenic epithelia. Significant expression is detected in lung epithelia, alveolar macrophages, horizontal cells in the retina and in embryonic organs such as heart, brain and spinal cord. Also expressed in pituitary gland, kidney, pancreas, trachea and thyroid gland. Autophosphorylated. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity signal transduction in response to DNA damage mitotic DNA damage checkpoint protein autophosphorylation perinuclear region of cytoplasm uc291uio.1 uc291uio.2 
ENSMUST00000090457.7 Dnaaf8 ENSMUST00000090457.7 dynein axonemal assembly factor 8, transcript variant 1 (non-coding) (from RefSeq NR_073370.2) ENSMUST00000090457.1 ENSMUST00000090457.2 ENSMUST00000090457.3 ENSMUST00000090457.4 ENSMUST00000090457.5 ENSMUST00000090457.6 NR_073370 uc007ybf.1 uc007ybf.2 uc007ybf.3 uc007ybf.4 uc007ybf.1 uc007ybf.2 uc007ybf.3 uc007ybf.4 
ENSMUST00000090461.12 Fyb1 ENSMUST00000090461.12 FYN binding protein 1, transcript variant 1 (from RefSeq NM_011815.5) ENSMUST00000090461.1 ENSMUST00000090461.10 ENSMUST00000090461.11 ENSMUST00000090461.2 ENSMUST00000090461.3 ENSMUST00000090461.4 ENSMUST00000090461.5 ENSMUST00000090461.6 ENSMUST00000090461.7 ENSMUST00000090461.8 ENSMUST00000090461.9 FYB1_MOUSE Fyb NM_011815 O35601 Q9Z2H3 uc007vdj.1 uc007vdj.2 uc007vdj.3 uc007vdj.4 The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]. Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (PubMed:9207119, PubMed:10497204). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (By similarity). Modulates the expression of IL2 (PubMed:9207119, PubMed:10497204). Involved in platelet activation (PubMed:17003372). Prevents the degradation of SKAP1 and SKAP2 (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493). Part of a complex consisting of SKAP2, FYB1 and PTPNS1 (PubMed:10469599). Part of a complex consisting of SKAP2, FYB1 and LILRB3 (PubMed:10469599). Part of a complex consisting of SKAP1, FYB1 and CLNK (PubMed:12681493). Interacts with CLNK (via its SH2 domain); this interaction allows SKAP1 and FYB1 to recruit FYN to the complex, thus promoting the phosphorylation of CLNK by FYN (PubMed:12681493, PubMed:10497204, PubMed:9207119). Interacts with FYN (PubMed:9207119, PubMed:10497204). Interacts with LCP2 (PubMed:9207119, PubMed:10497204). Interacts with SKAP1 (PubMed:12681493). Interacts with SKAP2 (PubMed:10469599, PubMed:11207596, PubMed:17003372). Interacts with FASLG (By similarity). Interacts with EVL (By similarity). Interacts with TMEM47 (PubMed:21881001). Interacts with LCK (By similarity). O35601; Q60787: Lcp2; NbExp=7; IntAct=EBI-7353747, EBI-5324248; O35601; Q9JJG6: Tmem47; NbExp=4; IntAct=EBI-7353747, EBI-11685657; Cytoplasm Nucleus Cell junction Note=Colocalizes with TMEM47 at cell- cell contacts in podocytes. Event=Alternative splicing; Named isoforms=2; Name=FYB-130; IsoId=O35601-1; Sequence=Displayed; Name=FYB-120; IsoId=O35601-2; Sequence=VSP_004261; Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non- lymphoid tissues. FYB-130 is preferentially expressed in mature T-cells compared to FYB-120, whereas thymocytes showed a greater relative amount of FYB-120. Expressed in podocytes. T-cell receptor ligation leads to increased tyrosine phosphorylation. Slight defects in platelet function. protein binding nucleus cytoplasm cytosol plasma membrane immune response integrin-mediated signaling pathway lipid binding actin cytoskeleton cell junction macromolecular complex binding T cell receptor signaling pathway protein localization to plasma membrane mast cell activation uc007vdj.1 uc007vdj.2 uc007vdj.3 uc007vdj.4 
ENSMUST00000090464.7 Cdc14a ENSMUST00000090464.7 CDC14 cell division cycle 14A, transcript variant 4 (from RefSeq NM_001378993.1) CC14A_MOUSE ENSMUST00000090464.1 ENSMUST00000090464.2 ENSMUST00000090464.3 ENSMUST00000090464.4 ENSMUST00000090464.5 ENSMUST00000090464.6 NM_001378993 Q6GQT0 Q8BZ66 uc008rca.1 uc008rca.2 Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis (By similarity). Required for normal hearing (PubMed:29293958). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Interacts with KIF20A. Interaction is required to localize CDC14 to the midzone of the mitotic spindle (By similarity). Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cell projection, kinocilium Cytoplasm, cytoskeleton, spindle pole Cell projection, stereocilium Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (By similarity). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (PubMed:27259055). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6GQT0-1; Sequence=Displayed; Name=2; IsoId=Q6GQT0-2; Sequence=VSP_012324; Expressed in the inner ear. Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold. Belongs to the protein-tyrosine phosphatase family. Non- receptor class CDC14 subfamily. microtubule cytoskeleton organization mitotic cell cycle spindle pole phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity nucleus nucleoplasm nucleolus cytoplasm centrosome microtubule organizing center spindle cytosol cytoskeleton protein dephosphorylation cell cycle regulation of exit from mitosis sensory perception of sound protein tyrosine/serine/threonine phosphatase activity dephosphorylation nuclear body hydrolase activity phosphatase activity stereocilium stereocilium tip positive regulation of cytokinesis peptidyl-tyrosine dephosphorylation cell projection cell division kinocilium cilium assembly mitotic cell cycle arrest mitotic spindle kinociliary basal body uc008rca.1 uc008rca.2 
ENSMUST00000090469.8 Myoz1 ENSMUST00000090469.8 myozenin 1 (from RefSeq NM_021508.3) ENSMUST00000090469.1 ENSMUST00000090469.2 ENSMUST00000090469.3 ENSMUST00000090469.4 ENSMUST00000090469.5 ENSMUST00000090469.6 ENSMUST00000090469.7 MYOZ1_MOUSE Myoz1 NM_021508 Q8C9L3 Q9D7N4 Q9JK37 uc007skd.1 uc007skd.2 uc007skd.3 Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT. Nucleus Cell projection, pseudopodium Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle (By similarity). Expressed primarily in skeletal muscle and specifically enriched in the gastrocnemius, which is composed predominantly of fast-twitch muscle fibers. Detected at lower levels in heart. At 9.5 dpc, expressed at significant levels in cardiac muscle with lower levels detected in skeletal muscle of tongue. At 15.5 dpc, cardiac expression is down-regulated and only weakly detected in atria, whereas skeletal muscle expression is more robust. Belongs to the myozenin family. negative regulation of transcription from RNA polymerase II promoter actin binding protein serine/threonine phosphatase inhibitor activity protein binding nucleus skeletal muscle tissue development actin cytoskeleton Z disc pseudopodium telethonin binding negative regulation of phosphoprotein phosphatase activity cell projection negative regulation of skeletal muscle tissue regeneration skeletal muscle fiber adaptation sarcomere organization FATZ binding negative regulation of calcineurin-NFAT signaling cascade uc007skd.1 uc007skd.2 uc007skd.3 
ENSMUST00000090473.7 Gpr88 ENSMUST00000090473.7 G-protein coupled receptor 88, transcript variant 1 (from RefSeq NM_022427.3) ENSMUST00000090473.1 ENSMUST00000090473.2 ENSMUST00000090473.3 ENSMUST00000090473.4 ENSMUST00000090473.5 ENSMUST00000090473.6 GPR88_MOUSE NM_022427 Q9EPB7 Strg uc008rbz.1 uc008rbz.2 uc008rbz.3 uc008rbz.4 Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (By similarity). May play a role in the regulation of cognitive and motor function (PubMed:26188600). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway (By similarity). Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells (By similarity). In on-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response (By similarity). Cell membrane ; Multi-pass membrane protein Cell projection, cilium membrane ; Multi-pass membrane protein Cytoplasm Nucleus Note=Localized to cilia in ciliated cells; whereas in non-ciliated cells, distributed throughout the cell membrane (By similarity). During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood. Expressed predominantly in the striatum. Mice have increased locomotion, increased motor stereotypical behavior, and impaired motor skill learning. Mutant mice also show facilitated hippocampal-mediated behaviors and decreased anxiety. Chronic blockade of delta opioid receptors and mu opioid, but not other Gi/o coupled receptors, using delta opioid receptor antagonist partially improved motor coordination and normalized spatial navigation and anxiety of mutant mice. Belongs to the G-protein coupled receptor 1 family. motor activity transmembrane signaling receptor activity G-protein coupled receptor activity nucleus cytoplasm plasma membrane integral component of plasma membrane cilium signal transduction G-protein coupled receptor signaling pathway phototransduction locomotory behavior G-protein coupled photoreceptor activity detection of visible light membrane integral component of membrane neuronal action potential neuromuscular process controlling balance motor learning cellular response to light stimulus uc008rbz.1 uc008rbz.2 uc008rbz.3 uc008rbz.4 
ENSMUST00000090475.10 Ehf ENSMUST00000090475.10 ets homologous factor (from RefSeq NM_007914.3) EHF_MOUSE ENSMUST00000090475.1 ENSMUST00000090475.2 ENSMUST00000090475.3 ENSMUST00000090475.4 ENSMUST00000090475.5 ENSMUST00000090475.6 ENSMUST00000090475.7 ENSMUST00000090475.8 ENSMUST00000090475.9 Ehf NM_007914 O70273 Q922E8 Q922T6 Q99K12 uc008lip.1 uc008lip.2 uc008lip.3 Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=O70273-1; Sequence=Displayed; Name=2 ; IsoId=O70273-2; Sequence=VSP_052191; Name=3 ; IsoId=O70273-3; Sequence=VSP_052192, VSP_052193; Highly expressed in kidney and lung, weakly in skeletal muscle, heart, and liver, and not detected in brain, spleen or testis. The PNT domain acts as a transcriptional activator. Belongs to the ETS family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm Golgi apparatus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cell differentiation epithelial cell differentiation sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter epithelial cell proliferation uc008lip.1 uc008lip.2 uc008lip.3 
ENSMUST00000090476.10 BC028528 ENSMUST00000090476.10 cDNA sequence BC028528, transcript variant 4 (from RefSeq NR_166868.1) CA054_MOUSE ENSMUST00000090476.1 ENSMUST00000090476.2 ENSMUST00000090476.3 ENSMUST00000090476.4 ENSMUST00000090476.5 ENSMUST00000090476.6 ENSMUST00000090476.7 ENSMUST00000090476.8 ENSMUST00000090476.9 NR_166868 Q8K3T8 Q8R2K8 uc290hru.1 uc290hru.2 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R2K8-1; Sequence=Displayed; Name=2; IsoId=Q8R2K8-2; Sequence=VSP_020746; molecular_function cellular_component extracellular region biological_process uc290hru.1 uc290hru.2 
ENSMUST00000090487.12 Garin1b ENSMUST00000090487.12 golgi associated RAB2 interactor 1B, transcript variant 3 (from RefSeq NM_207258.3) B2RW23 ENSMUST00000090487.1 ENSMUST00000090487.10 ENSMUST00000090487.11 ENSMUST00000090487.2 ENSMUST00000090487.3 ENSMUST00000090487.4 ENSMUST00000090487.5 ENSMUST00000090487.6 ENSMUST00000090487.7 ENSMUST00000090487.8 ENSMUST00000090487.9 Fam137a Fam71f1 GAR1B_MOUSE Garil1 Garin1b NM_207258 Q3UZD7 uc009bdf.1 uc009bdf.2 uc009bdf.3 RAB2B effector protein required for accurate acrosome formation and normal male fertility (PubMed:34714330). In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation (PubMed:34714330). Golgi apparatus Expressed in testis (at protein level). Expressed from day 21, around when spermiogenesis occurs (PubMed:34714330). Expression dramatically increases at the mid- round spermatid stage (steps 4-6) (PubMed:34714330). Mutant males are sterile (PubMed:34714330). Spermatozoa from mutant mice showed abnormal head shapes with an abnormal swollen acrosome morphology and impaired acrosome reaction (PubMed:34714330). Belongs to the GARIN family. molecular_function biological_process uc009bdf.1 uc009bdf.2 uc009bdf.3 
ENSMUST00000090499.13 Fam149b ENSMUST00000090499.13 family with sequence similarity 149, member B, transcript variant 15 (from RefSeq NR_189651.1) A0JLS8 ENSMUST00000090499.1 ENSMUST00000090499.10 ENSMUST00000090499.11 ENSMUST00000090499.12 ENSMUST00000090499.2 ENSMUST00000090499.3 ENSMUST00000090499.4 ENSMUST00000090499.5 ENSMUST00000090499.6 ENSMUST00000090499.7 ENSMUST00000090499.8 ENSMUST00000090499.9 F149B_MOUSE Fam149b1 Kiaa0974 NR_189651 Q6NSV7 Q6PES0 Q6ZQ13 Q8CCW6 Q8R3J2 uc007sjj.1 uc007sjj.2 uc007sjj.3 Involved in the localization of proteins to the cilium and cilium assembly. Indirectly regulates the signaling functions of the cilium, being required for normal SHH/smoothened signaling and proper development. Interacts with TBC1D32; may play a role in cilium assembly. Cell projection, cilium Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q6NSV7-1; Sequence=Displayed; Name=2; IsoId=Q6NSV7-2; Sequence=VSP_031535; Name=3; IsoId=Q6NSV7-3; Sequence=VSP_031542; Name=4; IsoId=Q6NSV7-4; Sequence=VSP_031536, VSP_031541; Name=5; IsoId=Q6NSV7-5; Sequence=VSP_031538, VSP_031539; Name=6; IsoId=Q6NSV7-6; Sequence=VSP_031536, VSP_031537, VSP_031540; Strong expression in the early embryonic stages 8 dpc, 9 dpc and 10 dpc in the neuroepithelium and by the maxillary arches. Belongs to the FAM149 family. Sequence=BAC98062.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process uc007sjj.1 uc007sjj.2 uc007sjj.3 
ENSMUST00000090500.10 Srl ENSMUST00000090500.10 sarcalumenin, transcript variant 3 (from RefSeq NM_001361474.2) A6H5Y7 ENSMUST00000090500.1 ENSMUST00000090500.2 ENSMUST00000090500.3 ENSMUST00000090500.4 ENSMUST00000090500.5 ENSMUST00000090500.6 ENSMUST00000090500.7 ENSMUST00000090500.8 ENSMUST00000090500.9 NM_001361474 Q7TQ48 Q8BS43 SRCA_MOUSE Sar Srl uc007xzu.1 uc007xzu.2 uc007xzu.3 Sarcoplasmic reticulum lumen Sarcoplasmic reticulum membrane ; Peripheral membrane protein Note=May associate with the sarcoplasmic reticulum membrane, via a calcium-dependent mechanism. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TQ48-2; Sequence=Displayed; Name=2; IsoId=Q7TQ48-1; Sequence=VSP_060764; N-glycosylated. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. store-operated calcium entry GTP binding response to muscle activity involved in regulation of muscle adaptation sarcoplasmic reticulum sarcoplasmic reticulum lumen uc007xzu.1 uc007xzu.2 uc007xzu.3 
ENSMUST00000090512.10 Grm8 ENSMUST00000090512.10 glutamate receptor, metabotropic 8, transcript variant 15 (from RefSeq NM_001409912.1) ENSMUST00000090512.1 ENSMUST00000090512.2 ENSMUST00000090512.3 ENSMUST00000090512.4 ENSMUST00000090512.5 ENSMUST00000090512.6 ENSMUST00000090512.7 ENSMUST00000090512.8 ENSMUST00000090512.9 GRM8_MOUSE Gprc1h Mglur8 NM_001409912 P47743 Q6B964 uc009bcj.1 uc009bcj.2 uc009bcj.3 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. Interacts with PICK1. Cell membrane; Multi-pass membrane protein. Strongly expressed in olfactory bulb, accessory olfactory bulb, and mammillary body. Weaker expression in the retina, and in scattered cells in the cortex and hindbrain. Belongs to the G-protein coupled receptor 3 family. group III metabotropic glutamate receptor activity G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway chemical synaptic transmission glutamate receptor activity membrane integral component of membrane synaptic transmission, glutamatergic presynaptic membrane neuron projection neuronal cell body regulation of neurotransmitter secretion response to stimulus detection of mechanical stimulus involved in sensory perception of pain regulation of synaptic transmission, glutamatergic glutamatergic synapse GABA-ergic synapse integral component of presynaptic active zone membrane regulation of synaptic vesicle exocytosis uc009bcj.1 uc009bcj.2 uc009bcj.3 
ENSMUST00000090522.5 Zfp597 ENSMUST00000090522.5 zinc finger protein 597 (from RefSeq NM_001033159.2) E9Q6S0 E9Q6S0_MOUSE ENSMUST00000090522.1 ENSMUST00000090522.2 ENSMUST00000090522.3 ENSMUST00000090522.4 NM_001033159 Zfp597 uc007xyu.1 uc007xyu.2 uc007xyu.3 molecular_function nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc007xyu.1 uc007xyu.2 uc007xyu.3 
ENSMUST00000090541.12 Atp5mc1 ENSMUST00000090541.12 ATP synthase membrane subunit c locus 1, transcript variant 1 (from RefSeq NM_007506.6) AT5G1_MOUSE Atp5g1 Atp5mc1 ENSMUST00000090541.1 ENSMUST00000090541.10 ENSMUST00000090541.11 ENSMUST00000090541.2 ENSMUST00000090541.3 ENSMUST00000090541.4 ENSMUST00000090541.5 ENSMUST00000090541.6 ENSMUST00000090541.7 ENSMUST00000090541.8 ENSMUST00000090541.9 NM_007506 Q3TIE9 Q9CR84 uc007lbg.1 uc007lbg.2 uc007lbg.3 uc007lbg.4 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element (By similarity). F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT- ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). Mitochondrion membrane ; Multi-pass membrane protein Trimethylated by ATPSCKMT at Lys-104. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Note=This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease). There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Belongs to the ATPase C chain family. mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) mitochondrion mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex ATP biosynthetic process ion transport lipid binding cold acclimation negative regulation of mitochondrial membrane potential hydrogen ion transmembrane transporter activity ATP synthesis coupled proton transport membrane integral component of membrane ligand-gated channel activity mitochondrial membrane proton-transporting two-sector ATPase complex, proton-transporting domain cation channel complex neuronal cell body proton-transporting ATP synthase complex, coupling factor F(o) response to ethanol positive regulation of axon extension ATP metabolic process pore complex assembly proton-transporting ATP synthase activity, rotational mechanism positive regulation of neuron death hydrogen ion transmembrane transport negative regulation of reactive oxygen species biosynthetic process cellular response to L-glutamate response to 3,3',5-triiodo-L-thyronine uc007lbg.1 uc007lbg.2 uc007lbg.3 uc007lbg.4 
ENSMUST00000090543.6 Nr1d2 ENSMUST00000090543.6 nuclear receptor subfamily 1, group D, member 2, transcript variant 1 (from RefSeq NM_011584.5) ENSMUST00000090543.1 ENSMUST00000090543.2 ENSMUST00000090543.3 ENSMUST00000090543.4 ENSMUST00000090543.5 NM_011584 NR1D2_MOUSE Nr1d2 Q60646 Q60674 uc007shp.1 uc007shp.2 uc007shp.3 uc007shp.4 This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. [provided by RefSeq, Feb 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.188347.1, SRR1660817.7258.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle. Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (PubMed:29355503). Key regulator of skeletal muscle mitochondrial function; negatively regulates the skeletal muscle expression of core clock genes and genes involved in mitochondrial biogenesis, fatty acid beta-oxidation and lipid metabolism (PubMed:29723273). May play a role in the circadian control of neutrophilic inflammation in the lung (PubMed:29533925). The heme-bound form can bind gaseous signaling molecules such as CO and nitric oxide (NO) and NO can reverse its transcriptional repressor activity. Binds DNA as a monomer or a homodimer (By similarity). Interacts with NCOA5 coactivator, leading to a strong increase of transcription of target genes (By similarity). Interacts (via N- terminus) with KAT5 (By similarity). Interacts (via C-terminus) with HDAC1 (By similarity). Interacts with ZNHIT1 (By similarity). Interacts with SIAH2 (By similarity). Q60674; Q9HCD5: NCOA5; Xeno; NbExp=2; IntAct=EBI-5326205, EBI-2863498; Nucleus toplasm Note=Phosphorylation by CSNK1E enhances its cytoplasmic localization. Ubiquitous. Expressed abundantly in skeletal muscle and brown adipose tissue. Expressed during skeletal muscle myogenesis. Activated by the CLOCK-BMAL1 heterodimer and DBP and repressed by CRY1. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Deacetylated by HDAC1 (By similarity). Acetylation and deacetylation regulate its transcriptional regulatory activity (By similarity). Under more reducing intracellular redox conditions, Cys-381 is in its heme-bound state, which is optimal for recruitment of the NCOR1/HDAC3 corepressor complex and repression of target genes (By similarity). When subjected to oxidative stress conditions, Cys-381 undergoes oxidation to form a disulfide bridge with Cys-371, also triggering a ligand switch that results in release of bound heme and derepression of target genes (By similarity). Ubiquitinated by SIAH2; leading to its proteasomal degradation. Phosphorylated by CSNK1E; phosphorylation enhances its cytoplasmic localization. Mice exhibit an altered circadian metabolism and feeding schedule, eating more and utilizing more carbohydrates as fuel during their nocturnal/sleep period (PubMed:29723273). Increased expression of circadian clock core genes and genes involved in lipid metabolism and fatty-acid oxidation in the skeletal muscle (PubMed:29723273). Mice exhibit decreased wakefulness and increased slow-wave sleep and rapid eye movement sleep during the dark phase (active period) (PubMed:29355503). Altered expression in the brain of core circadian clock genes and genes involved in sleep induction and wakefulness (PubMed:29355503). Conditional knockout of both NR1D1 and NR1D2 in bronchiolar epithelial cells abolished diurnal rhythmicity of PER2 in the bronchioles and increased inflammatory responses and chemokine activation (PubMed:29533925). Belongs to the nuclear hormone receptor family. NR1 subfamily. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated multicellular organism development transcription factor binding zinc ion binding hormone-mediated signaling pathway regulation of lipid metabolic process cell differentiation ligand-dependent nuclear receptor transcription coactivator activity intracellular receptor signaling pathway response to lipid signaling receptor activity regulation of circadian rhythm steroid hormone mediated signaling pathway sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding rhythmic process circadian behavior regulation of inflammatory response negative regulation of inflammatory response lipid homeostasis RNA polymerase II transcription factor complex energy homeostasis regulation of skeletal muscle cell differentiation uc007shp.1 uc007shp.2 uc007shp.3 uc007shp.4 
ENSMUST00000090546.6 Tmem167b ENSMUST00000090546.6 transmembrane protein 167B (from RefSeq NM_026198.2) ENSMUST00000090546.1 ENSMUST00000090546.2 ENSMUST00000090546.3 ENSMUST00000090546.4 ENSMUST00000090546.5 KISHB_MOUSE NM_026198 Q3U299 Q80X45 Q8BL15 Q9D863 uc008qzg.1 uc008qzg.2 uc008qzg.3 Involved in the early part of the secretory pathway. Golgi apparatus membrane ; Single- pass type I membrane protein Belongs to the KISH family. Golgi membrane molecular_function Golgi apparatus membrane integral component of membrane uc008qzg.1 uc008qzg.2 uc008qzg.3 
ENSMUST00000090553.12 Sars1 ENSMUST00000090553.12 seryl-tRNA synthetase 1, transcript variant 2 (from RefSeq NM_001204979.1) A2AFR8 ENSMUST00000090553.1 ENSMUST00000090553.10 ENSMUST00000090553.11 ENSMUST00000090553.2 ENSMUST00000090553.3 ENSMUST00000090553.4 ENSMUST00000090553.5 ENSMUST00000090553.6 ENSMUST00000090553.7 ENSMUST00000090553.8 ENSMUST00000090553.9 NM_001204979 P26638 SYSC_MOUSE Sars Sers uc008qzb.1 uc008qzb.2 uc008qzb.3 uc008qzb.4 Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA. Reaction=ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L- seryl-tRNA(Ser); Xref=Rhea:RHEA:12292, Rhea:RHEA-COMP:9669, Rhea:RHEA-COMP:9703, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:33384, ChEBI:CHEBI:78442, ChEBI:CHEBI:78533, ChEBI:CHEBI:456215; EC=6.1.1.11; Evidence=; Reaction=ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L- seryl-tRNA(Sec); Xref=Rhea:RHEA:42580, Rhea:RHEA-COMP:9742, Rhea:RHEA-COMP:10128, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:33384, ChEBI:CHEBI:78442, ChEBI:CHEBI:78533, ChEBI:CHEBI:456215; EC=6.1.1.11; Evidence=; Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. Homodimer. The tRNA molecule may bind across the dimer. Interacts with SIRT2. Interacts with METTL6; interaction is required for the tRNA N(3)-methylcytidine methyltransferase activity of METTL6. Cytoplasm Nucleus Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus. Consists of two distinct domains, a catalytic core and a N- terminal extension that is involved in tRNA binding. Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. negative regulation of transcription from RNA polymerase II promoter nucleotide binding RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding aminoacyl-tRNA ligase activity serine-tRNA ligase activity ATP binding nucleus cytoplasm mitochondrion cytosol translation tRNA aminoacylation for protein translation seryl-tRNA aminoacylation negative regulation of angiogenesis ligase activity protein homodimerization activity selenocysteinyl-tRNA(Sec) biosynthetic process negative regulation of vascular endothelial growth factor production uc008qzb.1 uc008qzb.2 uc008qzb.3 uc008qzb.4 
ENSMUST00000090558.11 Celsr2 ENSMUST00000090558.11 cadherin, EGF LAG seven-pass G-type receptor 2, transcript variant 1 (from RefSeq NM_017392.4) A2AEE7 CELR2_MOUSE Celsr2 ENSMUST00000090558.1 ENSMUST00000090558.10 ENSMUST00000090558.2 ENSMUST00000090558.3 ENSMUST00000090558.4 ENSMUST00000090558.5 ENSMUST00000090558.6 ENSMUST00000090558.7 ENSMUST00000090558.8 ENSMUST00000090558.9 NM_017392 Q99K26 Q9R0M0 Q9Z2R4 uc008qyx.1 uc008qyx.2 uc008qyx.3 uc008qyx.4 Receptor that may have an important role in cell/cell signaling during nervous system formation. Q9R0M0; Q7T0S3: atp6ap2.S; Xeno; NbExp=2; IntAct=EBI-8294754, EBI-8294706; Cell membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9R0M0-1; Sequence=Displayed; Name=2; IsoId=Q9R0M0-2; Sequence=VSP_025765; Expressed in the CNS and in the eye. Predominantly expressed in the developing CNS, the emerging dorsal root ganglia and cranial ganglia. In the CNS, expression is uniform along the rostrocaudal axis. During gastrulation, it is expressed within the anterior neural ectoderm. At 10 dpc, expression is strong in the ventricular zones (VZ) in all sectors of the brain, and lower in the marginal zones (MZ). Between 12 and 15 dpc, expression is prominent in the brain. It is strong in VZ, lower in MZ, except in telecephalic MZ where it is predominant. The intensity is higher in all VZ, and lower in differentiating fields than in VZ, except in the cerebral hemispheres, and to a lesser extent in the tectum and cerebellum. A weak expression is also observed in the fetal lungs, kidney and epithelia. In the newborn and postnatal stages, expression remains restricted to the VZ as well as in migrating and postmigratory cells throughout the brain. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. neuron migration cilium movement transmembrane signaling receptor activity G-protein coupled receptor activity calcium ion binding protein binding cytoplasm plasma membrane regulation of transcription, DNA-templated cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway multicellular organism development membrane integral component of membrane Wnt signaling pathway ventricular system development neural plate anterior/posterior regionalization regulation of cell-cell adhesion regulation of protein localization cerebrospinal fluid secretion dendrite morphogenesis cilium assembly cell-cell adhesion uc008qyx.1 uc008qyx.2 uc008qyx.3 uc008qyx.4 
ENSMUST00000090559.12 Cry2 ENSMUST00000090559.12 cryptochrome circadian regulator 2 (from RefSeq NM_009963.4) CRY2_MOUSE ENSMUST00000090559.1 ENSMUST00000090559.10 ENSMUST00000090559.11 ENSMUST00000090559.2 ENSMUST00000090559.3 ENSMUST00000090559.4 ENSMUST00000090559.5 ENSMUST00000090559.6 ENSMUST00000090559.7 ENSMUST00000090559.8 ENSMUST00000090559.9 Kiaa0658 NM_009963 O08706 Q6A024 Q9R194 uc008kxy.1 uc008kxy.2 uc008kxy.3 uc008kxy.4 uc008kxy.5 This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. [provided by RefSeq, Feb 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC054794.1, AK133781.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post- translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. Less potent transcriptional repressor in cerebellum and liver than CRY1, though less effective in lengthening the period of the SCN oscillator. Seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY1, dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. May mediate circadian regulation of cAMP signaling and gluconeogenesis by blocking glucagon-mediated increases in intracellular cAMP concentrations and in CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and NAMPT. Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (PubMed:28683290). Represses the transcriptional activity of NR1I2 (PubMed:28751364). Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. Only a minority of the protein molecules contain bound FAD. Contrary to the situation in photolyases, the FAD is bound in a shallow, surface-exposed pocket. ; Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate; Xref=ChEBI:CHEBI:15636; Evidence=; Note=Binds 1 5,10-methenyltetrahydrofolate (MTHF) non-covalently per subunit. ; KL001 (N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N- (2-furanylmethyl)-methanesulfonamide) binds to CRY1 and stabilizes it by inhibiting FBXL3- and ubiquitin-dependent degradation of CRY1 resulting in lengthening of the circadian periods. KL001-mediated CRY1 stabilization can inhibit glucagon-induced gluconeogenesis in primary hepatocytes. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins (PubMed:11779462). Interacts with TIMELESS (PubMed:10428031). Interacts directly with PER1, PER2 and PER3; interaction with PER2 inhibits its ubiquitination and vice versa (PubMed:10428031, PubMed:11875063, PubMed:14701732, PubMed:20840750, PubMed:24154698). Interacts with CLOCK-BMAL1 (PubMed:16628007). Interacts with BMAL1 (PubMed:16717091, PubMed:19917250, PubMed:20840750). Interacts with CLOCK (PubMed:16717091, PubMed:19917250). Interacts with NFIL3 (PubMed:17274955). Interacts with FBXL3 and FBXL21 (PubMed:17462724, PubMed:23452855, PubMed:23452856). FBXL3, PER2 and the cofactor FAD compete for overlapping binding sites (PubMed:24080726, PubMed:23503662). FBXL3 cannot bind CRY2 that interacts already with PER2 or that contains bound FAD (PubMed:23503662). Interacts with PPP5C (via TPR repeats); the interaction down-regulates the PPP5C phosphatase activity on CSNK1E (By similarity). Interacts with nuclear receptors AR and NR3C1/GR; the interaction is ligand dependent (PubMed:22170608, PubMed:28751364). Interacts with PRKDC (PubMed:24158435). Interacts with CIART (PubMed:24736997). Interacts with DDB1, USP7 and TARDBP (PubMed:27123980). Interacts with HNF4A (PubMed:28751364). Interacts with PPARA (PubMed:28683290). Interacts with PPARG in a ligand- dependent manner (PubMed:28683290). Interacts with PPARD (via domain NR LBD) in a ligand-dependent manner (PubMed:28683290, PubMed:28751364). Interacts with NR1I2 (via domain NR LBD) in a ligand-dependent manner (PubMed:28751364). Interacts with NR1I3 and VDR in a ligand-dependent manner (PubMed:28751364). Q9R194; Q9WTL8: Bmal1; NbExp=12; IntAct=EBI-1266619, EBI-644534; Q9R194; Q3TQ03: Ciart; NbExp=2; IntAct=EBI-1266619, EBI-16101489; Q9R194; P67871: Csnk2b; NbExp=3; IntAct=EBI-1266619, EBI-348179; Q9R194; Q8BFZ4: Fbxl21; NbExp=4; IntAct=EBI-1266619, EBI-6898235; Q9R194; Q8C4V4: Fbxl3; NbExp=6; IntAct=EBI-1266619, EBI-1266589; Q9R194; P06537-1: Nr3c1; NbExp=3; IntAct=EBI-1266619, EBI-15959147; Q9R194; O35973: Per1; NbExp=3; IntAct=EBI-1266619, EBI-1266764; Q9R194; O54943: Per2; NbExp=8; IntAct=EBI-1266619, EBI-1266779; Q9R194; Q9UKT7: FBXL3; Xeno; NbExp=13; IntAct=EBI-1266619, EBI-2557269; Q9R194; O15534: PER1; Xeno; NbExp=3; IntAct=EBI-1266619, EBI-2557276; Cytoplasm Nucleus Note=Translocated to the nucleus through interaction with other Clock proteins such as PER2 or BMAL1. Expression in the retina is restricted to the photoreceptor layer (at protein level) (PubMed:29561690). Expressed in all tissues examined including heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Weak expression in spleen. Shows no clear circadian oscillation pattern in testis, cerebellum nor liver. In skeletal muscle, under constant darkness and 12 hours light:12 hours dark conditions, levels peak between ZT6 and ZT9. Phosphorylation on Ser-265 by MAPK is important for the inhibition of CLOCK-BMAL1-mediated transcriptional activity. Phosphorylation by CSKNE requires interaction with PER1 or PER2. Phosphorylated in a circadian manner at Ser-553 and Ser-557 in the suprachiasmatic nucleus (SCN) and liver. Phosphorylation at Ser-557 by DYRK1A promotes subsequent phosphorylation at Ser-553 by GSK3-beta: the two-step phosphorylation at the neighboring Ser residues leads to its proteasomal degradation. Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complexes, regulating the balance between degradation and stabilization. The SCF(FBXL3) complex is mainly nuclear and mediates ubiquitination and subsequent degradation of CRY2. In contrast, cytoplasmic SCF(FBXL21) complex-mediated ubiquitination leads to stabilize CRY2 and counteract the activity of the SCF(FBXL3) complex. The SCF(FBXL3) and SCF(FBXL21) complexes probably mediate ubiquitination at different Lys residues. The SCF(FBXL3) complex recognizes and binds CRY2 phosphorylated at Ser- 553 and Ser-557. Ubiquitination may be inhibited by PER2. Deubiquitinated by USP7 (PubMed:27123980). Animals show longer circadian periods. Double knockouts of CRY1 and CRY2 show slightly decrease body weight and lose the cycling rhythmicity of feeding behavior, energy expenditure and glucocorticorids expression. Glucose homeostasis is severely disrupted and animals exhibit elevated blood glucose in response to acute feeding after an overnight fast as well as severely impaired glucose clearance in a glucose tolerance test. When challenged with high-fat diet, animals rapidly gain weight and surpass that of wild-type mice, despite displaying hypophagia. They exhibit hyperinsulinemia and selective insulin resistance in the liver and muscle but show high insulin sensitivity in adipose tissue and consequent increased lipid uptake. Mice display enlarged gonadal, subcutaneous and perirenal fat deposits with adipocyte hypertrophy and increased lipied accumulation in liver. Mice show attentuated circadian rhythms in photopic ERG b-wave amplitudes (PubMed:29561690). Both single CRY1 knockout and double CRY1 and CRY2 knockout mice show increased exercise performance and increased mitochondrial reserve capacity in primary myotubes (PubMed:28683290). Belongs to the DNA photolyase class-1 family. negative regulation of transcription from RNA polymerase II promoter nucleotide binding transcription regulatory region sequence-specific DNA binding DNA binding damaged DNA binding single-stranded DNA binding protein binding nucleus nucleoplasm cytoplasm mitochondrion cytosol protein import into nucleus circadian rhythm response to light stimulus photoreceptor activity response to activity nuclear speck protein-chromophore linkage kinase binding protein kinase binding phosphatase binding lipid storage negative regulation of phosphoprotein phosphatase activity response to insulin circadian regulation of gene expression nuclear hormone receptor binding glucose homeostasis regulation of circadian rhythm negative regulation of circadian rhythm entrainment of circadian clock by photoperiod negative regulation of transcription, DNA-templated rhythmic process response to stimulus FAD binding negative regulation of glucocorticoid receptor signaling pathway negative regulation of glucocorticoid secretion uc008kxy.1 uc008kxy.2 uc008kxy.3 uc008kxy.4 uc008kxy.5 
ENSMUST00000090563.7 Mybphl ENSMUST00000090563.7 myosin binding protein H-like (from RefSeq NM_026831.1) ENSMUST00000090563.1 ENSMUST00000090563.2 ENSMUST00000090563.3 ENSMUST00000090563.4 ENSMUST00000090563.5 ENSMUST00000090563.6 MBPHL_MOUSE Mybphl NM_026831 Q5FW53 uc008qyt.1 uc008qyt.2 Myosin-binding protein which plays a role in cardiac function (PubMed:28778945). Seems to regulate conduction in the atria and ventricular conduction systems (PubMed:28778945). Cytoplasm, myofibril, sarcomere Expressed in the atria as well as in discrete puncta throughout the right ventricular wall and septum. Knockout mouse hearts exhibit a 36% reduction in fractional shortening and an increased diastolic ventricular chamber size (PubMed:28778945). Mutants show cardiac conduction system abnormalities with aberrant atrioventricular conduction and an increased rate of arrhythmia (PubMed:28778945). Belongs to the immunoglobulin superfamily. MyBP family. in utero embryonic development uc008qyt.1 uc008qyt.2 
ENSMUST00000090569.10 Psma5 ENSMUST00000090569.10 proteasome subunit alpha 5 (from RefSeq NM_011967.3) ENSMUST00000090569.1 ENSMUST00000090569.2 ENSMUST00000090569.3 ENSMUST00000090569.4 ENSMUST00000090569.5 ENSMUST00000090569.6 ENSMUST00000090569.7 ENSMUST00000090569.8 ENSMUST00000090569.9 NM_011967 PSA5_MOUSE Q9Z2U1 uc008qyq.1 uc008qyq.2 uc008qyq.3 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:16857966, PubMed:22341445). PSMA5 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly (By similarity). Cytoplasm Nucleus Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. Detected in liver (at protein level). Belongs to the peptidase T1A family. proteasome complex endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteolysis ubiquitin-dependent protein catabolic process peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, alpha-subunit complex proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process uc008qyq.1 uc008qyq.2 uc008qyq.3 
ENSMUST00000090601.12 Cttnbp2 ENSMUST00000090601.12 cortactin binding protein 2, transcript variant 1 (from RefSeq NM_080285.2) B9EJA2 CTTB2_MOUSE ENSMUST00000090601.1 ENSMUST00000090601.10 ENSMUST00000090601.11 ENSMUST00000090601.2 ENSMUST00000090601.3 ENSMUST00000090601.4 ENSMUST00000090601.5 ENSMUST00000090601.6 ENSMUST00000090601.7 ENSMUST00000090601.8 ENSMUST00000090601.9 G3X9L7 Kiaa1758 NM_080285 Q69ZB2 Q8BVG1 Q8C044 uc009bal.1 uc009bal.2 uc009bal.3 Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons (By similarity). Activation of glutamate receptors weakens the interaction with STRN and STRN4 (By similarity). Cytoplasm, cell cortex. Cell projection, dendritic spine. Note=Remains associated with dendritic spines even after glutamate stimulation. Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=CTTNBP2-L; IsoId=B9EJA2-1; Sequence=Displayed; Name=2; Synonyms=CTTNBP2-S; IsoId=B9EJA2-2; Sequence=VSP_046474, VSP_046475; Name=3; Synonyms=CTTNBP2-intron; IsoId=B9EJA2-3; Sequence=VSP_046476, VSP_046477; Name=4; IsoId=B9EJA2-4; Sequence=VSP_046478; Name=5; IsoId=B9EJA2-5; Sequence=VSP_046473; Isoform 2 is predominantly expressed in brain (at protein level). In the brain, expressed at high levels in hypothalamus and striatum and at lower levels in cerebellum and cortex. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. [Isoform 3]: Due to intron retention. [Isoform 4]: May be due to competing acceptor splice site. Sequence=BAD32532.1; Type=Miscellaneous discrepancy; Note=Erroneous CDS prediction and frameshift.; Evidence=; cytoplasm cell cortex brain development synaptic vesicle SH3 domain binding cell projection dendritic spine regulation of synapse organization postsynaptic actin cytoskeleton glutamatergic synapse regulation of modification of postsynaptic actin cytoskeleton uc009bal.1 uc009bal.2 uc009bal.3 
ENSMUST00000090608.6 Harbi1 ENSMUST00000090608.6 harbinger transposase derived 1, transcript variant 1 (from RefSeq NM_178724.5) A2AH19 B7ZCF8 ENSMUST00000090608.1 ENSMUST00000090608.2 ENSMUST00000090608.3 ENSMUST00000090608.4 ENSMUST00000090608.5 HARB1_MOUSE NM_178724 Q8BNA8 Q8BNT1 Q8BR93 Q8C9N1 uc008kwp.1 uc008kwp.2 uc008kwp.3 Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity (By similarity). Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Interacts with NAIF1. Nucleus Cytoplasm Note=Interaction with NAIF1 promotes translocation to the nucleus. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BR93-1; Sequence=Displayed; Name=2; IsoId=Q8BR93-2; Sequence=VSP_021877, VSP_021878; Name=3; IsoId=Q8BR93-3; Sequence=VSP_021876, VSP_021879; Detected in adult brain, eye, nerve tissue and lung. Detected in embryo. Belongs to the HARBI1 family. molecular_function nuclease activity nucleus cytoplasm microtubule organizing center cytosol plasma membrane biological_process hydrolase activity metal ion binding nucleic acid phosphodiester bond hydrolysis uc008kwp.1 uc008kwp.2 uc008kwp.3 
ENSMUST00000090678.11 Rap1a ENSMUST00000090678.11 RAS-related protein 1a (from RefSeq NM_145541.5) ENSMUST00000090678.1 ENSMUST00000090678.10 ENSMUST00000090678.2 ENSMUST00000090678.3 ENSMUST00000090678.4 ENSMUST00000090678.5 ENSMUST00000090678.6 ENSMUST00000090678.7 ENSMUST00000090678.8 ENSMUST00000090678.9 Krev-1 NM_145541 P10113 P62835 RAP1A_MOUSE uc008qve.1 uc008qve.2 uc008qve.3 uc008qve.4 Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR. Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1. In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain) (By similarity). Interacts with TBC1D21 (PubMed:30360518). Interacts with RAP1GDS1 (By similarity). Cell membrane ; Lipid-anchor Cell junction Cytoplasm Cytoplasm, perinuclear region Early endosome Late endosome Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Colocalized with RAPGEF2 in the perinuclear region (By similarity). Localized with RAPGEF2 at cell-cell junctions. Expressed in the testis and sperm midpiece (at protein level). Belongs to the small GTPase superfamily. Ras family. nucleotide binding GTPase activity protein binding GTP binding cytoplasm endosome early endosome late endosome plasma membrane signal transduction small GTPase mediated signal transduction nervous system development response to carbohydrate positive regulation of neuron projection development membrane Ras GTPase binding Rap guanyl-nucleotide exchange factor activity GDP binding cell junction guanyl-nucleotide exchange factor complex Rap protein signal transduction negative regulation of collagen biosynthetic process cellular response to drug nerve growth factor signaling pathway neuron projection myelin sheath positive regulation of GTPase activity macromolecular complex binding phagocytic vesicle positive regulation of protein kinase activity positive regulation of glucose import perinuclear region of cytoplasm establishment of endothelial barrier positive regulation of ERK1 and ERK2 cascade cellular response to cAMP cellular response to glucose stimulus cellular response to organic cyclic compound protein localization to plasma membrane response to antineoplastic agent liver regeneration glutamatergic synapse regulation of cell junction assembly positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis cellular response to nerve growth factor stimulus negative regulation of synaptic vesicle exocytosis positive regulation of vasculogenesis uc008qve.1 uc008qve.2 uc008qve.3 uc008qve.4 
ENSMUST00000090680.11 Ddx20 ENSMUST00000090680.11 DEAD box helicase 20 (from RefSeq NM_017397.3) DDX20_MOUSE Dp103 ENSMUST00000090680.1 ENSMUST00000090680.10 ENSMUST00000090680.2 ENSMUST00000090680.3 ENSMUST00000090680.4 ENSMUST00000090680.5 ENSMUST00000090680.6 ENSMUST00000090680.7 ENSMUST00000090680.8 ENSMUST00000090680.9 Gemin3 NM_017397 Q059Z6 Q9JIK4 Q9JJY4 uc008qva.1 uc008qva.2 uc008qva.3 The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre- mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs) (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23681; Evidence=; Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP (By similarity). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG (By similarity). Interacts with SMN1; the interaction is direct (PubMed:10767334). Interacts with GEMIN4; the interaction is direct (By similarity). Interacts with GEMIN5 (By similarity). Interacts with SNUPN; the interaction is direct (By similarity). Interacts with PPP4R2 (By similarity). Interacts with FOXL2 (PubMed:16153597). Interacts with NANOS1 and PUM2 (By similarity). Cytoplasm Nucleus, gem Note=Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems). Belongs to the DEAD box helicase family. DDX20 subfamily. negative regulation of transcription from RNA polymerase II promoter nucleotide binding spliceosomal snRNP assembly nucleic acid binding DNA binding RNA binding RNA helicase activity helicase activity protein binding ATP binding nucleus cytoplasm cytosol mRNA processing negative regulation of cell proliferation RNA splicing hydrolase activity transcriptional repressor complex protein domain specific binding protein binding, bridging SMN complex SMN-Sm protein complex histone deacetylase binding positive regulation of apoptotic process negative regulation of transcription, DNA-templated oogenesis regulation of steroid biosynthetic process repressing transcription factor binding RNA polymerase II transcription repressor complex Gemini of coiled bodies uc008qva.1 uc008qva.2 uc008qva.3 
ENSMUST00000090682.4 Kbtbd4 ENSMUST00000090682.4 kelch repeat and BTB (POZ) domain containing 4, transcript variant 2 (from RefSeq NM_025991.5) A2AFW3 Bklhd4 ENSMUST00000090682.1 ENSMUST00000090682.2 ENSMUST00000090682.3 KBTB4_MOUSE NM_025991 Q8R179 Q9CQX1 uc008ktt.1 uc008ktt.2 uc008ktt.3 uc008ktt.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R179-1; Sequence=Displayed; Name=2; IsoId=Q8R179-2; Sequence=VSP_010221; uc008ktt.1 uc008ktt.2 uc008ktt.3 uc008ktt.4 
ENSMUST00000090697.11 Syt6 ENSMUST00000090697.11 synaptotagmin VI, transcript variant 1 (from RefSeq NM_018800.5) E9QJV2 ENSMUST00000090697.1 ENSMUST00000090697.10 ENSMUST00000090697.2 ENSMUST00000090697.3 ENSMUST00000090697.4 ENSMUST00000090697.5 ENSMUST00000090697.6 ENSMUST00000090697.7 ENSMUST00000090697.8 ENSMUST00000090697.9 NM_018800 Q9QUK7 Q9R0N8 SYT6_MOUSE uc290igd.1 uc290igd.2 May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (PubMed:15774481). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. ; Isoform 1: Homodimer; disulfide-linked via the cysteine motif (PubMed:10531343, PubMed:10531344). Isoform 1: Can also form heterodimers with SYT3, SYT7, SYT9 and SYT10 (PubMed:10531343, PubMed:10531344, PubMed:10871604). Isoform 1: Interacts with STX1A, STX1B and STX2; the interaction is Ca(2+)-dependent (PubMed:15774481). Isoform 2: Is not able to form homodimer and heterodimers (PubMed:10531344). Q9R0N8; Q9R0N4: Syt10; NbExp=2; IntAct=EBI-5239378, EBI-5239459; Q9R0N8; O35681: Syt3; NbExp=2; IntAct=EBI-5239378, EBI-457995; Q9R0N8; Q9R0N8: Syt6; NbExp=2; IntAct=EBI-5239378, EBI-5239378; Q9R0N8; Q9R0N9: Syt9; NbExp=2; IntAct=EBI-5239378, EBI-458006; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein [Isoform 1]: Membrane; Single-pass membrane protein. Note=Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment (PubMed:10531344). [Isoform 2]: Cytoplasm, cytosol Cell membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SytVI; IsoId=Q9R0N8-1; Sequence=Displayed; Name=2; Synonyms=SytVIdeltaTM1; IsoId=Q9R0N8-2; Sequence=VSP_041729; Isoform 1 is expressed in the olfactory bulb. Isoform 2 is expressed in the brain (at protein level). The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds. Belongs to the synaptotagmin family. SNARE binding phosphatidylserine binding calcium ion binding protein binding calcium-dependent phospholipid binding cytoplasm cytosol plasma membrane acrosome reaction regulation of dopamine secretion membrane integral component of membrane vesicle-mediated transport calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis extrinsic component of membrane syntaxin binding cell junction clathrin binding synaptic vesicle membrane cytoplasmic vesicle identical protein binding protein homodimerization activity synapse metal ion binding protein heterodimerization activity calcium-dependent protein binding acrosomal vesicle exocytosis exocytic vesicle cellular response to calcium ion perinuclear endoplasmic reticulum glutamatergic synapse presynaptic dense core vesicle exocytosis uc290igd.1 uc290igd.2 
ENSMUST00000090709.2 Or5i1 ENSMUST00000090709.2 olfactory receptor family 5 subfamily I member 1 (from RefSeq NM_146646.2) ENSMUST00000090709.1 G3X9L8 G3X9L8_MOUSE NM_146646 Olfr152 Or5i1 uc008koq.1 uc008koq.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This sequence is assembled by in silico methods with additional support of similarity to mouse olfactory receptors. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008koq.1 uc008koq.2 
ENSMUST00000090715.13 Ampd1 ENSMUST00000090715.13 adenosine monophosphate deaminase 1 (from RefSeq NM_001033303.2) AMPD1_MOUSE Ampd1 ENSMUST00000090715.1 ENSMUST00000090715.10 ENSMUST00000090715.11 ENSMUST00000090715.12 ENSMUST00000090715.2 ENSMUST00000090715.3 ENSMUST00000090715.4 ENSMUST00000090715.5 ENSMUST00000090715.6 ENSMUST00000090715.7 ENSMUST00000090715.8 ENSMUST00000090715.9 F8VPY9 NM_001033303 Q3V1D3 uc008qsp.1 uc008qsp.2 AMP deaminase plays a critical role in energy metabolism. Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14778; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. Homotetramer. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. AMP deaminase activity cytosol IMP biosynthetic process nucleotide metabolic process purine ribonucleoside monophosphate biosynthetic process response to organic substance hydrolase activity deaminase activity myosin heavy chain binding IMP salvage AMP metabolic process metal ion binding uc008qsp.1 uc008qsp.2 
ENSMUST00000090726.6 Slc43a3 ENSMUST00000090726.6 solute carrier family 43, member 3, transcript variant 24 (from RefSeq NR_185347.1) A2AVZ9 A6PX00 ENSMUST00000090726.1 ENSMUST00000090726.2 ENSMUST00000090726.3 ENSMUST00000090726.4 ENSMUST00000090726.5 Eeg1 Enbt1 NR_185347 Q5FW65 Q8C345 Q9JLF3 S43A3_MOUSE uc008kjn.1 uc008kjn.2 uc008kjn.3 uc008kjn.4 Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobases such as adenine, guanine and hypoxanthine (By similarity). May regulate fatty acid (FA) transport in adipocytes, acting as a positive regulator of FA efflux and as a negative regulator of FA uptake (PubMed:32217606). Reaction=adenine(out) = adenine(in); Xref=Rhea:RHEA:71523, ChEBI:CHEBI:16708; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71524; Evidence=; Reaction=guanine(out) = guanine(in); Xref=Rhea:RHEA:71531, ChEBI:CHEBI:16235; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71532; Evidence=; Reaction=hypoxanthine(out) = hypoxanthine(in); Xref=Rhea:RHEA:71515, ChEBI:CHEBI:17368; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71516; Evidence=; Basolateral cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AVZ9-1; Sequence=Displayed; Name=2; IsoId=A2AVZ9-2; Sequence=VSP_028193; High expression in the heart, followed by the lung, liver, spleen and kidney (PubMed:11704567). Highly expressed in adipose tissue (PubMed:32217606). Highly expressed in the early embryo. High expression at embryonic day 7 and later in the fetal liver, lung, placenta and kidney. Induced during the differentiation of adipocytes. Belongs to the SLC43A transporter (TC 2.A.1.44) family. Sequence=AAF26303.1; Type=Frameshift; Evidence=; integral component of plasma membrane membrane integral component of membrane transmembrane transport uc008kjn.1 uc008kjn.2 uc008kjn.3 uc008kjn.4 
ENSMUST00000090729.9 Ypel4 ENSMUST00000090729.9 yippee like 4 (from RefSeq NM_001005342.2) ENSMUST00000090729.1 ENSMUST00000090729.2 ENSMUST00000090729.3 ENSMUST00000090729.4 ENSMUST00000090729.5 ENSMUST00000090729.6 ENSMUST00000090729.7 ENSMUST00000090729.8 NM_001005342 Q65Z93 YPEL4_MOUSE uc008kjc.1 uc008kjc.2 uc008kjc.3 Nucleus, nucleolus. Detected in brain, spleen and testis. Belongs to the yippee family. molecular_function cellular_component nucleus nucleolus biological_process metal ion binding uc008kjc.1 uc008kjc.2 uc008kjc.3 
ENSMUST00000090746.3 Hmgcs2 ENSMUST00000090746.3 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (from RefSeq NM_008256.4) ENSMUST00000090746.1 ENSMUST00000090746.2 HMCS2_MOUSE NM_008256 P54869 Q64740 Q9DBK1 Q9DBM4 uc008qpr.1 uc008qpr.2 uc008qpr.3 uc008qpr.4 Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. Reaction=acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3- methylglutaryl-CoA + CoA + H(+); Xref=Rhea:RHEA:10188, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43074, ChEBI:CHEBI:57286, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.3.10; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10189; Evidence=; Kinetic parameters: KM=460 uM for acetyl-CoA ; Vmax=59 nmol/min/mg enzyme with acetyl-CoA as a substrate ; Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3. Homodimer. Mitochondrion Liver and kidney. Acetylation of Lys-427 is observed in liver mitochondria from fasted mice but not from fed mice. Succinylated. Desuccinylated by SIRT5. Succinylation, at least at Lys-83 and Lys-310, inhibits the enzymatic activity. Belongs to the thiolase-like superfamily. HMG-CoA synthase family. catalytic activity hydroxymethylglutaryl-CoA synthase activity mitochondrion mitochondrial inner membrane mitochondrial matrix acetyl-CoA metabolic process lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process steroid metabolic process cholesterol metabolic process isoprenoid biosynthetic process farnesyl diphosphate biosynthetic process, mevalonate pathway sterol biosynthetic process transferase activity uc008qpr.1 uc008qpr.2 uc008qpr.3 uc008qpr.4 
ENSMUST00000090759.5 Acp6 ENSMUST00000090759.5 acid phosphatase 6, lysophosphatidic (from RefSeq NM_019800.4) Acpl1 ENSMUST00000090759.1 ENSMUST00000090759.2 ENSMUST00000090759.3 ENSMUST00000090759.4 Lpap NM_019800 PPA6_MOUSE Q3TNE2 Q8BN33 Q8BP40 Q9JMG5 Q9QXG5 uc008qoq.1 uc008qoq.2 uc008qoq.3 uc008qoq.4 Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15018; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z- octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:39835, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:74544, ChEBI:CHEBI:75757; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39836; Evidence=; Monomer. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BP40-1; Sequence=Displayed; Name=2; IsoId=Q8BP40-2; Sequence=VSP_014123, VSP_014124; Belongs to the histidine acid phosphatase family. Sequence=AAF20010.1; Type=Frameshift; Evidence=; Sequence=BAA94308.1; Type=Frameshift; Evidence=; hematopoietic progenitor cell differentiation acid phosphatase activity cytoplasm mitochondrion lipid metabolic process phospholipid metabolic process dephosphorylation hydrolase activity lysophosphatidic acid phosphatase activity lysobisphosphatidic acid metabolic process uc008qoq.1 uc008qoq.2 uc008qoq.3 uc008qoq.4 
ENSMUST00000090760.9 Ppp1r1c ENSMUST00000090760.9 protein phosphatase 1, regulatory inhibitor subunit 1C, transcript variant 1 (from RefSeq NM_172420.4) A2AQD1 ENSMUST00000090760.1 ENSMUST00000090760.2 ENSMUST00000090760.3 ENSMUST00000090760.4 ENSMUST00000090760.5 ENSMUST00000090760.6 ENSMUST00000090760.7 ENSMUST00000090760.8 NM_172420 PPR1C_MOUSE Q3TZG5 Q8BKK4 Q8BKM4 uc008kgy.1 uc008kgy.2 uc008kgy.3 uc008kgy.4 May increase cell susceptibility to TNF-induced apoptosis. Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BKK4-1; Sequence=Displayed; Name=2; IsoId=Q8BKK4-2; Sequence=VSP_025059; Name=3; IsoId=Q8BKK4-3; Sequence=VSP_025060; Belongs to the protein phosphatase inhibitor 1 family. protein phosphatase inhibitor activity cytoplasm cell cycle signal transduction negative regulation of phosphoprotein phosphatase activity intracellular signal transduction cell division uc008kgy.1 uc008kgy.2 uc008kgy.3 uc008kgy.4 
ENSMUST00000090776.7 H2ac7 ENSMUST00000090776.7 H2A clustered histone 7 (from RefSeq NM_178188.4) C0HKE9 ENSMUST00000090776.1 ENSMUST00000090776.2 ENSMUST00000090776.3 ENSMUST00000090776.4 ENSMUST00000090776.5 ENSMUST00000090776.6 H2A1P_MOUSE Hist1h2ap NM_178188 P10812 P22752 Q149U0 Q5SZZ2 uc007pug.1 uc007pug.2 uc007pug.3 uc007pug.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC119295.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007pug.1 uc007pug.2 uc007pug.3 uc007pug.4 
ENSMUST00000090779.4 Gm20634 ENSMUST00000090779.4 Gm20634 (from geneSymbol) BC080809 ENSMUST00000090779.1 ENSMUST00000090779.2 ENSMUST00000090779.3 uc290hto.1 uc290hto.2 uc290hto.1 uc290hto.2 
ENSMUST00000090781.8 H2bc21 ENSMUST00000090781.8 H2B clustered histone 21 (from RefSeq NM_178214.5) ENSMUST00000090781.1 ENSMUST00000090781.2 ENSMUST00000090781.3 ENSMUST00000090781.4 ENSMUST00000090781.5 ENSMUST00000090781.6 ENSMUST00000090781.7 H2B2E_MOUSE H2bc21 Hist2h2be NM_178214 Q64524 uc008qmj.1 uc008qmj.2 uc008qmj.3 uc008qmj.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of a putative stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome lipopolysaccharide binding innate immune response in mucosa DNA binding protein binding extracellular space nucleus nucleoplasm chromosome cytosol nucleosome assembly negative regulation of tumor necrosis factor-mediated signaling pathway antibacterial humoral response killing of cells of other organism protein heterodimerization activity defense response to Gram-negative bacterium defense response to Gram-positive bacterium plasma membrane uc008qmj.1 uc008qmj.2 uc008qmj.3 uc008qmj.4 
ENSMUST00000090782.4 H2ac20 ENSMUST00000090782.4 H2A clustered histone 20 (from RefSeq NM_175662.3) ENSMUST00000090782.1 ENSMUST00000090782.2 ENSMUST00000090782.3 H2A2C_MOUSE H2ac20 Hist2h2ab Hist2h2ac NM_175662 Q64523 Q8CGP3 uc008qmi.1 uc008qmi.2 uc008qmi.3 uc008qmi.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc008qmi.1 uc008qmi.2 uc008qmi.3 uc008qmi.4 
ENSMUST00000090785.9 Otud7b ENSMUST00000090785.9 OTU domain containing 7B, transcript variant 1 (from RefSeq NM_001025613.1) B2RUR8 ENSMUST00000090785.1 ENSMUST00000090785.2 ENSMUST00000090785.3 ENSMUST00000090785.4 ENSMUST00000090785.5 ENSMUST00000090785.6 ENSMUST00000090785.7 ENSMUST00000090785.8 NM_001025613 OTU7B_MOUSE Q8CFS0 uc008qma.1 uc008qma.2 Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF- kappa-B (PubMed:23334419). Negatively regulates mucosal immunity against infections (PubMed:23334419). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (PubMed:26903241). Mediates deubiquitination of EGFR (By similarity). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure. Hydrolyzes both linear and branched forms of polyubiquitin (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Deubiquitinase activity is inhibited following interaction with PARK7. Interacts with TRAF6. Interacts with PARK7, leading to inhibit deubiquitinase activity. Interacts with EGFR, ITCH and NEDD4 (By similarity). Interacts with TRAF3 (PubMed:23334419). Interacts with ZAP70 in activated T cells, but not in resting T cells (PubMed:26903241). B2RUR8; P25942: CD40; Xeno; NbExp=2; IntAct=EBI-3454264, EBI-525714; Cytoplasm Nucleus Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner. The protein undergoes a significant conformation change upon binding to ubiquitinated substrates. The loop that precedes the active site is in an autoinhibitory conformation in the apoprotein. Ubiquitin binding leads to a conformation change; the loop is stabilized in a catalytically competent conformation with the result that the active site Cys can form the reaction state intermediate. Phosphorylated by EGFR. No visible phenotype in neonates (PubMed:26903241). Mice do not show obvious defects in survival, except a moderately reduced body weight (PubMed:23334419). They however display hyperactivation of non-canonical NF-kappa-B without affecting canonical NF-kappa-B activation. Mice show B-cell hyper-responsiveness to antigens, lymphoid follicular hyperplasia in the intestinal mucosa and elevated host-defense ability against an intestinal bacterial pathogen, Citrobacter rodentium (PubMed:23334419). At 12 months after birth, mutant mice display impaired T cell homeostasis with increased numbers of naive T cells and reduced numbers of Th1 memory-like T cells (PubMed:26903241). Young adults that have no overt change in T cell homeostasis still show impaired production of effector T cells in response to repeated stimulation with an antigen and an impaired defense against infection by L.monocytogenes (PubMed:26903241). Conversely, mutant mice are less susceptible to experimentally induced autoimmune encephalitis (PubMed:26903241). Belongs to the peptidase C64 family. Sequence=AAH37040.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; negative regulation of transcription from RNA polymerase II promoter in utero embryonic development adaptive immune response immune system process mucosal immune response DNA binding thiol-dependent ubiquitin-specific protease activity protein binding nucleus cytoplasm proteolysis peptidase activity cysteine-type peptidase activity zinc ion binding protein deubiquitination hydrolase activity negative regulation of interleukin-8 production protein K11-linked deubiquitination thiol-dependent ubiquitinyl hydrolase activity negative regulation of I-kappaB kinase/NF-kappaB signaling metal ion binding K63-linked polyubiquitin binding protein K63-linked deubiquitination protein K48-linked deubiquitination protein deubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of protein localization to nucleus Lys48-specific deubiquitinase activity uc008qma.1 uc008qma.2 
ENSMUST00000090791.8 Rprd2 ENSMUST00000090791.8 regulation of nuclear pre-mRNA domain containing 2, transcript variant 2 (from RefSeq NM_001368178.2) ENSMUST00000090791.1 ENSMUST00000090791.2 ENSMUST00000090791.3 ENSMUST00000090791.4 ENSMUST00000090791.5 ENSMUST00000090791.6 ENSMUST00000090791.7 Kiaa0460 NM_001368178 Q3U3L8 Q6NXI6 Q6ZQA7 RPRD2_MOUSE uc008qkx.1 uc008qkx.2 uc008qkx.3 Associates with the RNA polymerase II complex. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NXI6-1; Sequence=Displayed; Name=2; IsoId=Q6NXI6-2; Sequence=VSP_019548; RNA polymerase II core binding DNA-directed RNA polymerase II, holoenzyme mRNA 3'-end processing uc008qkx.1 uc008qkx.2 uc008qkx.3 
ENSMUST00000090811.11 Scrn3 ENSMUST00000090811.11 secernin 3, transcript variant 1 (from RefSeq NM_029022.1) A2AWR0 ENSMUST00000090811.1 ENSMUST00000090811.10 ENSMUST00000090811.2 ENSMUST00000090811.3 ENSMUST00000090811.4 ENSMUST00000090811.5 ENSMUST00000090811.6 ENSMUST00000090811.7 ENSMUST00000090811.8 ENSMUST00000090811.9 NM_029022 Q3TMH2 Q91WF6 Q9CUT0 SCRN3_MOUSE uc008kcm.1 uc008kcm.2 uc008kcm.3 Belongs to the peptidase C69 family. Secernin subfamily. molecular_function proteolysis dipeptidase activity uc008kcm.1 uc008kcm.2 uc008kcm.3 
ENSMUST00000090813.6 Sp9 ENSMUST00000090813.6 trans-acting transcription factor 9, transcript variant 2 (from RefSeq NM_001409583.1) ENSMUST00000090813.1 ENSMUST00000090813.2 ENSMUST00000090813.3 ENSMUST00000090813.4 ENSMUST00000090813.5 NM_001409583 Q5QR89 Q64HY3 SP9_MOUSE uc008kcj.1 uc008kcj.2 uc008kcj.3 uc008kcj.4 Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q64HY3-1; Sequence=Displayed; Name=2; IsoId=Q64HY3-2; Sequence=VSP_039467; Detected in the apical ectodermal ridge (AER) during limb development as well as in the distal region of the ectoderm. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In SP9, the motif is inactive. Belongs to the Sp1 C2H2-type zinc-finger protein family. RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleic acid binding DNA binding nucleus regulation of transcription from RNA polymerase II promoter embryonic limb morphogenesis metal ion binding uc008kcj.1 uc008kcj.2 uc008kcj.3 uc008kcj.4 
ENSMUST00000090815.6 Gm128 ENSMUST00000090815.6 predicted gene 128 (from RefSeq NM_001024841.3) ENSMUST00000090815.1 ENSMUST00000090815.2 ENSMUST00000090815.3 ENSMUST00000090815.4 ENSMUST00000090815.5 MENT_MOUSE Ment NM_001024841 Q569E4 uc008qiw.1 uc008qiw.2 uc008qiw.3 Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B. Secreted High expression in testis, but low in other tissues. Phosphorylation sites are present in the extracellular medium. No visible phenotype. Mice lacking Ment are viable and have no overt fertility phenotype. molecular_function cellular_component extracellular region regulation of cell proliferation uc008qiw.1 uc008qiw.2 uc008qiw.3 
ENSMUST00000090823.8 Sema6c ENSMUST00000090823.8 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C, transcript variant 1 (from RefSeq NM_001272024.1) E9Q613 E9Q613_MOUSE ENSMUST00000090823.1 ENSMUST00000090823.2 ENSMUST00000090823.3 ENSMUST00000090823.4 ENSMUST00000090823.5 ENSMUST00000090823.6 ENSMUST00000090823.7 NM_001272024 Sema6c uc008qih.1 uc008qih.2 uc008qih.3 uc008qih.4 Lacks conserved residue(s) required for the propagation of feature annotation. axon guidance membrane integral component of membrane semaphorin receptor binding uc008qih.1 uc008qih.2 uc008qih.3 uc008qih.4 
ENSMUST00000090824.12 Map3k20 ENSMUST00000090824.12 mitogen-activated protein kinase kinase kinase 20, transcript variant 1 (from RefSeq NM_023057.6) ENSMUST00000090824.1 ENSMUST00000090824.10 ENSMUST00000090824.11 ENSMUST00000090824.2 ENSMUST00000090824.3 ENSMUST00000090824.4 ENSMUST00000090824.5 ENSMUST00000090824.6 ENSMUST00000090824.7 ENSMUST00000090824.8 ENSMUST00000090824.9 M3K20_MOUSE Map3k20 Mltk NM_023057 Q3V1X8 Q8BR73 Q9ESL3 Q9ESL4 Zak uc008kbv.1 uc008kbv.2 uc008kbv.3 Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:11042189, PubMed:27598200). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11042189). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (By similarity). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (By similarity). [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV- B irradiation (PubMed:32289254). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR) (PubMed:32289254). Directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (By similarity). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (By similarity). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (By similarity). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (By similarity). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (By similarity). [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress. May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated in response to stress, such as ribosomal stress, osmotic shock and ionizing radiation. Activated by phosphorylation by PKN1, followed by autophosphorylation on Thr-161 and Ser-165. Homodimer (PubMed:11042189). Interacts with ZNF33A (By similarity). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, MAP3K20 and MAP2K3 (By similarity). Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and MAP3K20 (By similarity). Interacts with EIF2AK4/GCN2; promoting EIF2AK4/GCN2 kinase activity (By similarity). [Isoform ZAKalpha]: Interacts with isoform ZAKbeta. [Isoform ZAKbeta]: Interacts with isoform ZAKalpha. Cytoplasm Nucleus Note=Appears to shuttle between nucleus and cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=ZAKalpha; Synonyms=Alpha; IsoId=Q9ESL4-1; Sequence=Displayed; Name=ZAKbeta; Synonyms=Beta; IsoId=Q9ESL4-2; Sequence=VSP_051745, VSP_051746; Name=3 ; IsoId=Q9ESL4-3; Sequence=VSP_051747, VSP_051748; Mainly expressed in heart and developing limbs. [Isoform ZAKalpha]: Recognizes stalled ribosomes via two separate and partially redundant sensor domains: the C-terminal domain (CTD) that binds the 18S ribosomal RNA (18S rRNA) and the sensing domain (S). Activated by phosphorylation by PKN1, followed by autophosphorylation on Thr-161 and Ser-165 (By similarity). Autophosphorylation in response to ribotoxic stress promotes dissociation from colliding ribosomes and activation (By similarity). Knockout results in fully penetrant lethality at 9.5 dpc due to severe cardiac edema and growth retardation (PubMed:26755636). Embryos show polydactyly of the feet (PubMed:26755636). Defects in stress-activated protein kinase signaling cascade in response to ribotoxic stress, leading to impaired activation of the JNK and MAP kinase p38 pathways (PubMed:27598200). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. DNA damage checkpoint nucleotide binding activation of MAPKK activity magnesium ion binding protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity ATP binding nucleus cytoplasm cytosol protein phosphorylation cytoskeleton organization cell cycle cell cycle arrest mitotic cell cycle checkpoint activation of JUN kinase activity kinase activity phosphorylation transferase activity intracellular signal transduction embryonic digit morphogenesis positive regulation of apoptotic process metal ion binding stress-activated MAPK cascade limb development cellular response to gamma radiation uc008kbv.1 uc008kbv.2 uc008kbv.3 
ENSMUST00000090826.12 Rapgef4 ENSMUST00000090826.12 Rap guanine nucleotide exchange factor (GEF) 4, transcript variant 1 (from RefSeq NM_001204165.1) Cgef2 ENSMUST00000090826.1 ENSMUST00000090826.10 ENSMUST00000090826.11 ENSMUST00000090826.2 ENSMUST00000090826.3 ENSMUST00000090826.4 ENSMUST00000090826.5 ENSMUST00000090826.6 ENSMUST00000090826.7 ENSMUST00000090826.8 ENSMUST00000090826.9 Epac2 NM_001204165 Q8VIP9 Q9CW52 Q9EQZ6 Q9Z1P0 RPGF4_MOUSE uc008kbn.1 uc008kbn.2 uc008kbn.3 uc008kbn.4 Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2. Interacts with RAP1B, RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. Q9EQZ6; P01112: HRAS; Xeno; NbExp=3; IntAct=EBI-772212, EBI-350145; Q9EQZ6-3; P61224: RAP1B; Xeno; NbExp=3; IntAct=EBI-15566495, EBI-358143; Cytoplasm. Membrane ; Peripheral membrane protein Event=Alternative promoter usage, Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9EQZ6-1; Sequence=Displayed; Name=2; IsoId=Q9EQZ6-2; Sequence=VSP_007614; Name=3; IsoId=Q9EQZ6-3; Sequence=VSP_007615; Expressed in cerebellum, pituitary, adrenal gland and liver. The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2. The DEP domain is involved in membrane localization independent from regulation by cAMP. [Isoform 1]: Produced by alternative promoter usage. [Isoform 2]: Produced by alternative promoter usage. [Isoform 3]: Produced by alternative splicing of isoform 1. nucleotide binding photoreceptor outer segment photoreceptor inner segment guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity protein binding cytoplasm cytosol plasma membrane brush border cilium exocytosis signal transduction small GTPase mediated signal transduction postsynaptic density positive regulation of smooth muscle cell migration membrane basolateral plasma membrane apical plasma membrane Ras GTPase binding calcium ion regulated exocytosis regulation of exocytosis cAMP-mediated signaling insulin secretion axon dendrite growth cone cAMP binding macromolecular complex intracellular signal transduction neuronal cell body dendritic spine cone cell pedicle macromolecular complex binding positive regulation of protein secretion regulation of dendrite development negative regulation of synaptic transmission excitatory synapse glutamatergic synapse positive regulation of neuronal action potential uc008kbn.1 uc008kbn.2 uc008kbn.3 uc008kbn.4 
ENSMUST00000090827.12 Pgap3 ENSMUST00000090827.12 post-GPI attachment to proteins 3 (from RefSeq NM_001033537.2) A2A558 A2A559 ENSMUST00000090827.1 ENSMUST00000090827.10 ENSMUST00000090827.11 ENSMUST00000090827.2 ENSMUST00000090827.3 ENSMUST00000090827.4 ENSMUST00000090827.5 ENSMUST00000090827.6 ENSMUST00000090827.7 ENSMUST00000090827.8 ENSMUST00000090827.9 NM_001033537 PGAP3_MOUSE Perld1 Q3TCA8 uc007lgh.1 uc007lgh.2 uc007lgh.3 Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (By similarity). Golgi apparatus membrane ; Multi- pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Mainly localizes to Golgi apparatus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2A559-1; Sequence=Displayed; Name=2; IsoId=A2A559-2; Sequence=VSP_034159; Belongs to the PGAP3 family. Golgi membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus GPI anchor metabolic process GPI anchor biosynthetic process membrane integral component of membrane hydrolase activity, acting on ester bonds intrinsic component of endoplasmic reticulum membrane uc007lgh.1 uc007lgh.2 uc007lgh.3 
ENSMUST00000090839.12 Selenbp1 ENSMUST00000090839.12 selenium binding protein 1 (from RefSeq NM_009150.3) ENSMUST00000090839.1 ENSMUST00000090839.10 ENSMUST00000090839.11 ENSMUST00000090839.2 ENSMUST00000090839.3 ENSMUST00000090839.4 ENSMUST00000090839.5 ENSMUST00000090839.6 ENSMUST00000090839.7 ENSMUST00000090839.8 ENSMUST00000090839.9 Lpsb NM_009150 P17563 Q91X87 SBP1_MOUSE uc008qhf.1 uc008qhf.2 uc008qhf.3 Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity). Reaction=H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 + hydrogen sulfide; Xref=Rhea:RHEA:11812, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16007, ChEBI:CHEBI:16240, ChEBI:CHEBI:16842, ChEBI:CHEBI:29919; EC=1.8.3.4; Evidence=; Kinetic parameters: KM=5 nM for methanethiol ; Organosulfur degradation. Interacts with USP33. Nucleus Cytoplasm, cytosol Membrane ; Peripheral membrane protein Note=May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity). Highly expressed in liver, kidney and, to a lesser extent, lung. The N-terminus is blocked. SELENBP1 knockout results in accumulation of dimethylsulfoxide in the plasma. Methanethiol oxidase activity measured in tissues from knockout mice is significantly lower that in normal tissues. Belongs to the selenium-binding protein family. fibrillar center nucleus nucleolus cytoplasm cytosol selenium binding protein transport membrane oxidoreductase activity methanethiol oxidase activity brown fat cell differentiation oxidation-reduction process uc008qhf.1 uc008qhf.2 uc008qhf.3 
ENSMUST00000090848.10 Selenbp2 ENSMUST00000090848.10 selenium binding protein 2 (from RefSeq NM_019414.2) A0A0R4J135 A0A0R4J135_MOUSE ENSMUST00000090848.1 ENSMUST00000090848.2 ENSMUST00000090848.3 ENSMUST00000090848.4 ENSMUST00000090848.5 ENSMUST00000090848.6 ENSMUST00000090848.7 ENSMUST00000090848.8 ENSMUST00000090848.9 NM_019414 Selenbp2 uc008qgx.1 uc008qgx.2 uc008qgx.3 Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport. Reaction=H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 + hydrogen sulfide; Xref=Rhea:RHEA:11812, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16007, ChEBI:CHEBI:16240, ChEBI:CHEBI:16842, ChEBI:CHEBI:29919; EC=1.8.3.4; Evidence=; Organosulfur degradation. Interacts with USP33. Nucleus Cytoplasm, cytosol Membrane ; Peripheral membrane protein Note=May associate with Golgi membrane. May associate with the membrane of autophagosomes. Belongs to the selenium-binding protein family. selenium binding uc008qgx.1 uc008qgx.2 uc008qgx.3 
ENSMUST00000090853.5 Gm5773 ENSMUST00000090853.5 Not detected in any embryonic stages tested. Weakly expressed in adult testis. (from UniProt Q717B2) B2RUE5 E9QNP4 ENSMUST00000090853.1 ENSMUST00000090853.2 ENSMUST00000090853.3 ENSMUST00000090853.4 Q717B2 TDPZ2_MOUSE Tdpoz2 uc290hgq.1 uc290hgq.2 Not detected in any embryonic stages tested. Weakly expressed in adult testis. Belongs to the Tdpoz family. nucleus cytoplasm ubiquitin-dependent protein catabolic process regulation of proteolysis ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process uc290hgq.1 uc290hgq.2 
ENSMUST00000090858.10 Ppig ENSMUST00000090858.10 peptidyl-prolyl isomerase G (cyclophilin G), transcript variant 19 (from RefSeq NM_001407483.1) A2AR02 ENSMUST00000090858.1 ENSMUST00000090858.2 ENSMUST00000090858.3 ENSMUST00000090858.4 ENSMUST00000090858.5 ENSMUST00000090858.6 ENSMUST00000090858.7 ENSMUST00000090858.8 ENSMUST00000090858.9 NM_001407483 O70134 PPIG_MOUSE Q3TP68 Q3UXE0 uc008jyl.1 uc008jyl.2 uc008jyl.3 PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Inhibited by cyclosporin A (CsA). Interacts with CLK1, PNN and with the phosphorylated C- terminal domain of RNA polymerase II. Nucleus matrix Nucleus speckle Note=Colocalizes with splicing factors at nuclear speckles. The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II. protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity nucleus cytosol protein folding cyclosporin A binding nuclear matrix nuclear speck isomerase activity protein refolding unfolded protein binding uc008jyl.1 uc008jyl.2 uc008jyl.3 
ENSMUST00000090863.5 Lce3f ENSMUST00000090863.5 late cornified envelope 3F (from RefSeq NM_001018079.2) ENSMUST00000090863.1 ENSMUST00000090863.2 ENSMUST00000090863.3 ENSMUST00000090863.4 Lce3f NM_001018079 Q6PAI4 Q6PAI4_MOUSE uc008qey.1 uc008qey.2 Belongs to the LCE family. epidermis development uc008qey.1 uc008qey.2 
ENSMUST00000090866.2 Lce1i ENSMUST00000090866.2 late cornified envelope 1I (from RefSeq NM_029667.2) ENSMUST00000090866.1 Lce1i NM_029667 Q9D6P5 Q9D6P5_MOUSE uc008qer.1 uc008qer.2 Belongs to the LCE family. epidermis development uc008qer.1 uc008qer.2 
ENSMUST00000090867.2 Lce1e ENSMUST00000090867.2 late cornified envelope 1E (from RefSeq NM_026811.2) ENSMUST00000090867.1 Lce1e NM_026811 Q9D139 Q9D139_MOUSE uc008qen.1 uc008qen.2 uc008qen.3 epidermis development uc008qen.1 uc008qen.2 uc008qen.3 
ENSMUST00000090871.3 Sprr2a2 ENSMUST00000090871.3 Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (By similarity). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (PubMed:34735226). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (By similarity). (from UniProt Q9CQK8) BC010818 ENSMUST00000090871.1 ENSMUST00000090871.2 O70553 Q9CQK8 SP2A1_MOUSE Sprr2a Sprr2a1 uc033hvg.1 uc033hvg.2 uc033hvg.3 Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (By similarity). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (PubMed:34735226). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (By similarity). Secreted Secreted, extracellular space Cytoplasmic vesicle, secretory vesicle Note=Present in intestinal secretory epithelial cells and is secreted into the intestinal lumen. By type-2 cytokines IL4 and IL13 in response to helminth infection. Forms five pairs of intrachain disulfide bonds. Mice lacking Sprr2a1, Sprr2a2 and Sprr2a3 show an expansion of Gram-positive bacteria in the small intestinal lumen and mucus layer (PubMed:34735226). Mice were born in normal Mendelian ratios, are healthy and show normal intestinal morphology with no signs of inflammation in normal conditions (PubMed:34735226). They however show an increased abundance of Gram-positive bacteria in the small intestinal lumen, with a marked increase in the relative abundance of Lactobacillus, Turicibacter, and C.arthromitus (PubMed:34735226). At the same time, a reduction in the abundance of Bacteroidetes, a class of Gram-negative bacteria is observed (PubMed:34735226). Mice are more susceptible to L. monocytogenes infection (PubMed:34735226). Belongs to the cornifin (SPRR) family. cornified envelope structural constituent of cytoskeleton nucleus cytoplasm cytoskeleton organization regulation of cell shape epidermis development keratinocyte differentiation keratinization response to estradiol uc033hvg.1 uc033hvg.2 uc033hvg.3 
ENSMUST00000090927.12 Clk2 ENSMUST00000090927.12 CDC-like kinase 2, transcript variant 2 (from RefSeq NM_001163432.2) Clk2 ENSMUST00000090927.1 ENSMUST00000090927.10 ENSMUST00000090927.11 ENSMUST00000090927.2 ENSMUST00000090927.3 ENSMUST00000090927.4 ENSMUST00000090927.5 ENSMUST00000090927.6 ENSMUST00000090927.7 ENSMUST00000090927.8 ENSMUST00000090927.9 F8WHX0 F8WHX0_MOUSE NM_001163432 uc008pxu.1 uc008pxu.2 uc008pxu.3 uc008pxu.4 uc008pxu.5 Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation uc008pxu.1 uc008pxu.2 uc008pxu.3 uc008pxu.4 uc008pxu.5 
ENSMUST00000090940.6 Ermn ENSMUST00000090940.6 ermin, ERM-like protein (from RefSeq NM_029972.4) ENSMUST00000090940.1 ENSMUST00000090940.2 ENSMUST00000090940.3 ENSMUST00000090940.4 ENSMUST00000090940.5 ERMIN_MOUSE Kiaa1189 NM_029972 Q3UVY3 Q5DTZ8 Q5EBJ4 Q8C5L8 Q9CTR3 uc008jsh.1 uc008jsh.2 uc008jsh.3 Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity). Binds actin. Cytoplasm, cytoskeleton Brain and spinal cord. Exclusively expressed by the oligodendrocytes. Appears at a late stage during myelination, and in the mature nerves, it is localized to the outer cytoplasmic lip of the myelin sheath and the paranodal loops. Weakly detectable in the first 3 postnatal days, but increases during the initial 2 weeks after birth. Sequence=BAC37121.1; Type=Frameshift; Evidence=; Sequence=BAD90431.1; Type=Erroneous initiation; Evidence=; morphogenesis of a branching structure actin binding cytoplasm cytoskeleton cell cortex actin filament organization regulation of cell shape filopodium regulation of cell projection organization internode region of axon paranode region of axon neuronal cell body myelin sheath actin filament binding uc008jsh.1 uc008jsh.2 uc008jsh.3 
ENSMUST00000090971.11 Bcan ENSMUST00000090971.11 brevican, transcript variant 20 (from RefSeq NR_176865.1) ENSMUST00000090971.1 ENSMUST00000090971.10 ENSMUST00000090971.2 ENSMUST00000090971.3 ENSMUST00000090971.4 ENSMUST00000090971.5 ENSMUST00000090971.6 ENSMUST00000090971.7 ENSMUST00000090971.8 ENSMUST00000090971.9 NR_176865 PGCB_MOUSE Q61361 Q80WT7 uc008pto.1 uc008pto.2 uc008pto.3 uc008pto.4 May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Interacts with TNR. Secreted, extracellular space, extracellular matrix Secreted Expressed in the retina, specifically around the inner and outer segments of photoreceptors, retinal pigment epithelium, outer plexiform layer, and the ganglion cell layer (at protein level) (PubMed:29777959). Brain (PubMed:9286696, PubMed:14550776, PubMed:22121037). Expressed in the brainstem and cerebellum in a perineuronal net pattern (PubMed:14550776, PubMed:22121037). O-glycosylated; contains chondroitin sulfate. Belongs to the aggrecan/versican proteoglycan family. Name=Functional Glycomics Gateway - Glycan Binding; Note=Brevican; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_155"; skeletal system development calcium ion binding hyaluronic acid binding extracellular region extracellular space cell adhesion cell-matrix adhesion central nervous system development cell surface hippocampus development carbohydrate binding axon dendrite extracellular matrix anchored component of membrane node of Ranvier axon initial segment synapse synapse maturation perineuronal net perisynaptic extracellular matrix glutamatergic synapse GABA-ergic synapse neuron projection extension uc008pto.1 uc008pto.2 uc008pto.3 uc008pto.4 
ENSMUST00000090986.11 Fcrl2 ENSMUST00000090986.11 Fc receptor like 2, transcript variant 2 (from RefSeq NM_030707.4) ENSMUST00000090986.1 ENSMUST00000090986.10 ENSMUST00000090986.2 ENSMUST00000090986.3 ENSMUST00000090986.4 ENSMUST00000090986.5 ENSMUST00000090986.6 ENSMUST00000090986.7 ENSMUST00000090986.8 ENSMUST00000090986.9 Fcrl2 Fcrls MMAN-g Msr2 NM_030707 Q9EQY5 Q9EQY5_MOUSE uc008pry.1 uc008pry.2 uc008pry.3 Lacks conserved residue(s) required for the propagation of feature annotation. scavenger receptor activity endocytosis membrane uc008pry.1 uc008pry.2 uc008pry.3 
ENSMUST00000090990.6 Tcl1b3 ENSMUST00000090990.6 T cell leukemia/lymphoma 1B, 3 (from RefSeq NM_013772.2) ENSMUST00000090990.1 ENSMUST00000090990.2 ENSMUST00000090990.3 ENSMUST00000090990.4 ENSMUST00000090990.5 NM_013772 Q0VBM6 Q0VBM6_MOUSE Tcl1b3 uc007oya.1 uc007oya.2 uc007oya.3 Belongs to the TCL1 family. protein serine/threonine kinase activator activity positive regulation of protein serine/threonine kinase activity uc007oya.1 uc007oya.2 uc007oya.3 
ENSMUST00000091014.10 Map9 ENSMUST00000091014.10 microtubule-associated protein 9, transcript variant 1 (from RefSeq NM_001081230.1) Asap ENSMUST00000091014.1 ENSMUST00000091014.2 ENSMUST00000091014.3 ENSMUST00000091014.4 ENSMUST00000091014.5 ENSMUST00000091014.6 ENSMUST00000091014.7 ENSMUST00000091014.8 ENSMUST00000091014.9 MAP9_MOUSE Mtap9 NM_001081230 Q3TRR0 Q3UUD1 Q3UX85 Q3UXE7 Q5M8N8 Q6P8K1 Q8BMM4 Q8BYP7 uc008poy.1 uc008poy.2 Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules (By similarity). Binds to purified microtubules via its C-terminus. Cytoplasm. Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, spindle Note=Localizes to microtubules in interphase, associates with the mitotic spindle during mitosis, localizes to the central body during cytokinesis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TRR0-1; Sequence=Displayed; Name=2; IsoId=Q3TRR0-2; Sequence=VSP_020039; Sequence=AAH61216.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH87935.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AK147287; Type=Frameshift; Evidence=; astral microtubule mitotic cytokinesis cytoplasm aster spindle cytoskeleton microtubule cell cycle microtubule binding microtubule cytoskeleton axon regulation of mitotic centrosome separation spindle assembly spindle midzone cell division regulation of mitotic spindle organization mitotic spindle mitotic spindle assembly regulation of mitotic cytokinesis mitotic spindle midzone uc008poy.1 uc008poy.2 
ENSMUST00000091023.3 4930589L23Rik ENSMUST00000091023.3 RIKEN cDNA 4930589L23 gene (from RefSeq NR_152118.1) ENSMUST00000091023.1 ENSMUST00000091023.2 NR_152118 uc290gbi.1 uc290gbi.2 uc290gbi.3 uc290gbi.1 uc290gbi.2 uc290gbi.3 
ENSMUST00000091039.5 Ralgps1 ENSMUST00000091039.5 Ral GEF with PH domain and SH3 binding motif 1, transcript variant 1 (from RefSeq NM_175211.5) A2AR50 A2AR51 A2AR52 ENSMUST00000091039.1 ENSMUST00000091039.2 ENSMUST00000091039.3 ENSMUST00000091039.4 Kiaa0351 NM_175211 Q6GQS4 Q6ZQD2 Q8BVR9 Q8C1I2 RGPS1_MOUSE Ralgef2 Ralgps1a uc008jhm.1 uc008jhm.2 uc008jhm.3 uc008jhm.4 Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeleton organization. Interacts with the SH3 domains of GRB2, NCK1, PLCG1 and SRC. Cytoplasm Cell membrane Note=Associates with membranes through the PH domain. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=A2AR50-1; Sequence=Displayed; Name=2; IsoId=A2AR50-2; Sequence=VSP_033482, VSP_033485; Name=3; IsoId=A2AR50-3; Sequence=VSP_033486; Name=4; IsoId=A2AR50-4; Sequence=VSP_033483, VSP_033484; The PH domain mediates binding to membranes. It is required for efficient GEF activity. Sequence=BAC25535.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC25535.1; Type=Frameshift; Evidence=; Sequence=BAC97933.1; Type=Erroneous initiation; Evidence=; Sequence=CAM22215.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM25545.1; Type=Erroneous gene model prediction; Evidence=; guanyl-nucleotide exchange factor activity cellular_component cytoplasm plasma membrane small GTPase mediated signal transduction Ral guanyl-nucleotide exchange factor activity membrane regulation of Ral protein signal transduction uc008jhm.1 uc008jhm.2 uc008jhm.3 uc008jhm.4 
ENSMUST00000091064.8 Rraga ENSMUST00000091064.8 Ras-related GTP binding A (from RefSeq NM_178376.3) B1AXR0 ENSMUST00000091064.1 ENSMUST00000091064.2 ENSMUST00000091064.3 ENSMUST00000091064.4 ENSMUST00000091064.5 ENSMUST00000091064.6 ENSMUST00000091064.7 NM_178376 Q80X95 Q8C1S2 Q8CFU3 RRAGA_MOUSE Rraga uc008tlw.1 uc008tlw.2 uc008tlw.3 uc008tlw.4 uc008tlw.5 Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:23263183). Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagA/RRAGA is in its active form when GTP-bound RagA/RRAGA forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagA/RRAGA heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) (PubMed:23263183). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:23263183). Involved in the RCC1/Ran-GTPase pathway (By similarity). May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; The activation of GTP-binding proteins is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). The Ragulator complex functions as a GEF and promotes the active GTP-bound form (By similarity). The GATOR1 complex functions as a GAP and stimulates RRAGA GTPase activity to turn it into its inactive GDP-bound form, preventing mTORC1 recruitment and activation (By similarity). Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner; heterodimerization stabilizes proteins of the heterodimer (By similarity). The GTP-bound form of RRAGA (in complex with the GDP-bound form of RRAGC or RRAGD) interacts with RPTOR, thereby promoting recruitment of mTORC1 to the lysosomes (By similarity). The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor (By similarity). The Rag heterodimer interacts with the Ragulator complex (By similarity). The GTP-bound form of RRAGA interacts with NOL8 (By similarity). Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator (By similarity). Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGA and is negatively regulated by amino acids (By similarity). Interacts (polyubiquitinated) with TSC2 (By similarity). Interacts with SESN1, SESN2 and SESN3 (By similarity). Interacts with PIP4P1 (PubMed:29644770). Interacts with GPR137B (By similarity). Cytoplasm Nucleus Lysosome membrane Note=Predominantly cytoplasmic. Recruited to the lysosome surface by the Ragulator complex. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Polybiquitinated via 'Lys-63'-linked polyubiquitination by RNF152 in response to amino acid starvation: polyubiquitination of the GDP- bound inactive form by RNF152 promotes RRAGA inactivation and interaction with the GATOR1 complex. This does not affect RRAGA degradation. Belongs to the GTR/RAG GTP-binding protein family. Sequence=AAH37615.1; Type=Erroneous initiation; Evidence=; Sequence=BAC25103.1; Type=Frameshift; Evidence=; nucleotide binding GTPase activity protein binding GTP binding nucleus cytoplasm lysosome apoptotic process cell death cellular response to starvation regulation of autophagy negative regulation of autophagy modulation by virus of host morphology or physiology ubiquitin protein ligase binding positive regulation of TOR signaling cellular response to amino acid starvation EGO complex cellular protein localization regulation of cytolysis protein homodimerization activity response to amino acid positive regulation of cytolysis protein heterodimerization activity phosphoprotein binding cellular response to amino acid stimulus regulation of TORC1 signaling positive regulation of TORC1 signaling Iml1 complex Gtr1-Gtr2 GTPase complex uc008tlw.1 uc008tlw.2 uc008tlw.3 uc008tlw.4 uc008tlw.5 
ENSMUST00000091130.5 ENSMUSG00000121776 ENSMUST00000091130.5 ENSMUSG00000121776 (from geneSymbol) AF463524 ENSMUST00000091130.1 ENSMUST00000091130.2 ENSMUST00000091130.3 ENSMUST00000091130.4 uc290fgs.1 uc290fgs.2 uc290fgs.1 uc290fgs.2 
ENSMUST00000091137.6 Frem2 ENSMUST00000091137.6 Fras1 related extracellular matrix protein 2 (from RefSeq NM_172862.3) ENSMUST00000091137.1 ENSMUST00000091137.2 ENSMUST00000091137.3 ENSMUST00000091137.4 ENSMUST00000091137.5 FREM2_MOUSE NM_172862 Nv1 Q4W2Q5 Q5H8C0 Q6NVD0 Q811G9 Q8C4G5 Q8CD46 uc008pey.1 uc008pey.2 Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (By similarity). Required for epidermal adhesion (PubMed:15838507). Involved in the development of eyelids and the anterior segment of the eyeballs (PubMed:30802441). Interacts with FREM1. Q6NVD0; Q80T14: Fras1; NbExp=2; IntAct=EBI-15594269, EBI-15594303; Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6NVD0-1; Sequence=Displayed; Name=2; IsoId=Q6NVD0-2; Sequence=VSP_015038, VSP_015039; Name=3; IsoId=Q6NVD0-3; Sequence=VSP_015037; First expressed from 10 dpc in the mesodermal core of the branchial arches, developing lens, otic vesicle and limb apical ectodermal ridge. Later, it is expressed in the vibrissae and vibrissae pad, eyelids ear and pelage follicles and, at low levels, in the epidermis (PubMed:15838507). Also expressed in caudal somites and, in later embryos, in facial, limb and intercostal muscles (PubMed:15838507). In contrast to Frem1, it is not expressed in the developing mammary glands or in the caecum (PubMed:15838507). Restricted to the epithelia in a pattern complementary to that of Frem1 (which is generally expressed in the dermis and mesenchyme) (PubMed:15838507). In the developing kidney, it is expressed At in the mesonephric and metanephric epithelia at 11.5 dpc, with a highest expression at the tips of the developing ureteric buds (PubMed:15838507). At 12.5 and 13.5 dpc, it is still expressed throughout the epithelial components of the kidney, including epithelia fated to form nephrons, which are induced by the ureter tips to differeintiate from the mesenchymal condensations that surround them (PubMed:15838507). Expressed in retinal neuron-containing outer plexiform layer (PubMed:30802441). The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding. Mice display cryptophthalmos, syndactyly and renal defects. Frem2 corresponds to the X-ray irradiated-induced allele 'myelencephalic blebs' (my). Belongs to the FRAS1 family. eye development morphogenesis of an epithelium protein binding basement membrane plasma membrane cell communication cell adhesion multicellular organism development heart development membrane integral component of membrane embryonic digit morphogenesis metal ion binding inner ear development uc008pey.1 uc008pey.2 
ENSMUST00000091142.4 Urm1 ENSMUST00000091142.4 ubiquitin related modifier 1 (from RefSeq NM_026615.4) A3KGW2 ENSMUST00000091142.1 ENSMUST00000091142.2 ENSMUST00000091142.3 NM_026615 Q8BHY9 Q9D2P4 URM1_MOUSE uc008jag.1 uc008jag.2 uc008jag.3 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. Cytoplasm C-terminal thiocarboxylation occurs in 2 steps, it is first acyl- adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3. Belongs to the URM1 family. tRNA wobble uridine modification cytoplasm cytosol tRNA processing protein urmylation tRNA thio-modification sulfur carrier activity uc008jag.1 uc008jag.2 uc008jag.3 
ENSMUST00000091178.2 Sry ENSMUST00000091178.2 sex determining region of Chr Y (from RefSeq NM_011564.1) ENSMUST00000091178.1 NM_011564 Q53WV7 Q53WV7_MOUSE Sry uc012hrv.1 uc012hrv.2 DNA binding nucleus uc012hrv.1 uc012hrv.2 
ENSMUST00000091180.3 H2al1j ENSMUST00000091180.3 H2A histone family member L1J (from RefSeq NM_001114529.1) A2BFR3 A2BFR3_MOUSE ENSMUST00000091180.1 ENSMUST00000091180.2 Gm4906 H2al1j NM_001114529 uc012hew.1 uc012hew.2 The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc012hew.1 uc012hew.2 
ENSMUST00000091184.9 Slc25a31 ENSMUST00000091184.9 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 (from RefSeq NM_178386.3) ADT4_MOUSE Aac4 Ant4 ENSMUST00000091184.1 ENSMUST00000091184.2 ENSMUST00000091184.3 ENSMUST00000091184.4 ENSMUST00000091184.5 ENSMUST00000091184.6 ENSMUST00000091184.7 ENSMUST00000091184.8 NM_178386 Q3V132 Q80W28 Sfec Slc25a31 uc008pbi.1 uc008pbi.2 uc008pbi.3 uc008pbi.4 ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c- state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes (PubMed:17137571, PubMed:17681941, PubMed:19556438). Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis (PubMed:19556438). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31489369). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Among nucleotides, may also exchange ADP for dATP and dADP (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31489369). It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it (PubMed:31489369). Reaction=ADP(in) + ATP(out) = ADP(out) + ATP(in); Xref=Rhea:RHEA:34999, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35000; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:35001; Evidence=; Reaction=ADP(in) + dATP(out) = ADP(out) + dATP(in); Xref=Rhea:RHEA:73699, ChEBI:CHEBI:61404, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73700; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:73701; Evidence=; Reaction=ADP(out) + dADP(in) = ADP(in) + dADP(out); Xref=Rhea:RHEA:72855, ChEBI:CHEBI:57667, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72856; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:72857; Evidence=; Reaction=H(+)(in) = H(+)(out); Xref=Rhea:RHEA:34979, ChEBI:CHEBI:15378; Evidence=; The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA). The cytoplasmic-open state (c-state) is inhibited by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR) (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity (By similarity). Monomer. Mitochondrion inner membrane ; Multi- pass membrane protein Membrane ; Multi-pass membrane protein Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein Note=In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region (By similarity). May localize to non-mitochondrial membranes (By similarity). Specifically expressed in undifferentiated embryonic stem cells and germ cells (PubMed:16051982, PubMed:31489369). Expression is down-regulated after embryonic stem cells differentiation (PubMed:16051982). In adults, only expressed in developing gametes in testis (PubMed:16051982). In testis, expressed at higher level in spermatocytes. Expression is probably associated with entry of the male germ cells into meiosis (PubMed:17681941). Expressed at very low level in Sertoli cells (PubMed:17681941). In testis, expression increases upon transition of premeiotic type B spermatogonia into the early stages of meiosis as represented by preleptotene spermatocytes (PubMed:17681941). Continues to increase through the leptotene and zygotene spermatocyte stages, peaking in early pachytene spermatocytes (PubMed:17681941). Expression decreases in late pachytene spermatocytes and in later round spermatids (PubMed:17681941). Expression is repressed by E2F6. The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue. Male mice display a significant reduction in testicular size and are sterile, due to impaired spermatogenesis (PubMed:17681941). Males show increased levels of apoptosis within the spermatocyte layer of the seminiferous epithelium, accompanied by the absence of spermatids and spermatozoa within the seminiferous epithelium and lumen respectively (PubMed:17681941). Early meiotic arrest: an accumulation of leptotene spermatocytes, a decrease in pachytene spermatocytes and an absence of diplotene spermatocytes are observed in spermatocytes (PubMed:19556438). Deletion of Slc25a4/Ant1, Slc25a5/Ant2 and Slc25a31/Ant4 in liver completely inhibits mitochondrial permeability transition pore (mPTP) (PubMed:31489369). Mice lacking Slc25a4/Ant1, Slc25a5/Ant2, Slc25a31/Ant4 and Ppif lack Ca(2+)-induced mPTP formation (PubMed:31489369). Belongs to the mitochondrial carrier (TC 2.A.29) family. ATP:ADP antiporter activity mitochondrion mitochondrial inner membrane cilium ADP transport ATP transport membrane integral component of membrane transmembrane transporter activity motile cilium cell projection transmembrane transport uc008pbi.1 uc008pbi.2 uc008pbi.3 uc008pbi.4 
ENSMUST00000091186.7 Intu ENSMUST00000091186.7 inturned planar cell polarity protein, transcript variant 1 (from RefSeq NM_175515.6) ENSMUST00000091186.1 ENSMUST00000091186.2 ENSMUST00000091186.3 ENSMUST00000091186.4 ENSMUST00000091186.5 ENSMUST00000091186.6 INTU_MOUSE Kiaa1284 NM_175515 Pdzd6 Q059U7 Q80TG0 Q8BS60 Q8C9Y0 uc033htd.1 uc033htd.2 Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (PubMed:20067783, PubMed:21761479). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). Interacts with CPLANE1. Interacts with FUZ and WDPCP; FUZ, INTU and WDPCP probably form the core CPLANE (ciliogenesis and planar polarity effectors) complex. Cytoplasm Cell surface Cytoplasm, cytoskeleton, cilium basal body Note=Enriched at the apical surface in ciliated cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q059U7-1; Sequence=Displayed; Name=2; IsoId=Q059U7-2; Sequence=VSP_042603, VSP_042604, VSP_042605; Widely expressed in E8.5 and E9.5 wild type embryos. Present in various adult organs (at protein level). Embryos die at midgestation. Embryos exhibit multiple defects including neural tube closure defects, abnormal dorsal/ventral patterning of the central nervous system and abnormal anterior-posterior patterning of the limbs resulting in severe polydactyly. Fewer and shorter cilia are present in mutant embryos. In mice lacking both Intu and Fuz, the lack of convergent extension and more severe patterning defects in Intu and Fuz mutants does not result from a functional redundancy between these proteins. Belongs to the inturned family. establishment of planar polarity molecular_function cytoplasm cytoskeleton multicellular organism development nervous system development regulation of smoothened signaling pathway cell surface negative regulation of keratinocyte proliferation spinal cord dorsal/ventral patterning neural tube development cell projection organization keratinocyte differentiation regulation of ossification hair follicle morphogenesis motile cilium ciliary basal body embryonic digit morphogenesis cell projection motile cilium assembly positive regulation of smoothened signaling pathway negative regulation of cell division limb development cilium assembly non-motile cilium assembly uc033htd.1 uc033htd.2 
ENSMUST00000091188.7 Usp9y ENSMUST00000091188.7 ubiquitin specific peptidase 9, Y chromosome (from RefSeq NM_148943.2) ENSMUST00000091188.1 ENSMUST00000091188.2 ENSMUST00000091188.3 ENSMUST00000091188.4 ENSMUST00000091188.5 ENSMUST00000091188.6 F8VPU6 NM_148943 Q91XW2 USP9Y_MOUSE Usp9y uc009uzo.1 uc009uzo.2 Deubiquitinase that mediates deubiquitination of target proteins. May stabilize target proteins that are important for male germ cell development. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Protein modification; protein ubiquitination. Belongs to the peptidase C19 family. cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity cytoplasm ubiquitin-dependent protein catabolic process protein deubiquitination thiol-dependent ubiquitinyl hydrolase activity uc009uzo.1 uc009uzo.2 
ENSMUST00000091190.12 Ddx3y ENSMUST00000091190.12 DEAD box helicase 3, Y-linked (from RefSeq NM_012008.2) D1Pas1-rs1 DDX3Y_MOUSE Dead2 ENSMUST00000091190.1 ENSMUST00000091190.10 ENSMUST00000091190.11 ENSMUST00000091190.2 ENSMUST00000091190.3 ENSMUST00000091190.4 ENSMUST00000091190.5 ENSMUST00000091190.6 ENSMUST00000091190.7 ENSMUST00000091190.8 ENSMUST00000091190.9 NM_012008 Q62095 Q9QWS9 uc009uzm.1 uc009uzm.2 uc009uzm.3 uc009uzm.4 Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (PubMed:30475900). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Cytoplasm Nucleus Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner. Found in heart, brain, liver, skeletal muscle, kidney and testis. Low expression detected in lung. In testis, expressed in all types of spermatogenic cells including spermatogonia, spermatocytes, spermatids and somatic Sertoli cells within the seminiferous tubules. Also expressed in Leydig cells and other interstitial cells. Knockout males show normal spermatogenesis, produce morphologically normal spermatozoa and sire healthy offspring (PubMed:30613052). DDX3X and DDX3Y double knockout is embryonic lethal (PubMed:30613052). DDX3X and DDX3Y double knockout germ cells can differentiate into spermatozoa (PubMed:30613052). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus cytoplasm cytosol gamete generation hydrolase activity cell differentiation P granule uc009uzm.1 uc009uzm.2 uc009uzm.3 uc009uzm.4 
ENSMUST00000091197.4 Eif2s3y ENSMUST00000091197.4 eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked, transcript variant 1 (from RefSeq NM_012011.2) ENSMUST00000091197.1 ENSMUST00000091197.2 ENSMUST00000091197.3 IF2H_MOUSE NM_012011 Q9Z0N2 uc009uzd.1 uc009uzd.2 uc009uzd.3 uc009uzd.4 uc009uzd.5 Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). Along with its paralog on chromosome X, may contribute to spermatogenesis up to the round spermatid stage (PubMed:11528390, PubMed:25579647, PubMed:26823431). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.3; Evidence=; eIF2 is an heterotrimer composed of an alpha (EIF2S1), a beta (EIF2S2) and a gamma (Eif2s3x and Eif2s3y) chain. eIF2 is member of the 43S pre-initiation complex (43S PIC). Widely expressed. In the adult brain, high levels in hippocampus, habenula, hypothalamic nuclei and cerebellum. Also expressed in embryonic brain. Knockout males are infertile. Their testes are smaller as compared to wild-type fertile males and exhibit spermatogonial proliferation block. Has a homolog on chromosome X (Eif2s3x). Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. nucleotide binding formation of translation preinitiation complex translation initiation factor activity GTPase activity GTP binding cytoplasm cytosol eukaryotic translation initiation factor 2 complex translation translational initiation positive regulation of translational fidelity tRNA binding uc009uzd.1 uc009uzd.2 uc009uzd.3 uc009uzd.4 uc009uzd.5 
ENSMUST00000091201.7 Arl15 ENSMUST00000091201.7 ADP-ribosylation factor-like 15 (from RefSeq NM_172595.5) ARL15_MOUSE Arfrp2 ENSMUST00000091201.1 ENSMUST00000091201.2 ENSMUST00000091201.3 ENSMUST00000091201.4 ENSMUST00000091201.5 ENSMUST00000091201.6 NM_172595 Q8BGR6 uc007rxj.1 uc007rxj.2 uc007rxj.3 Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTP binding biological_process uc007rxj.1 uc007rxj.2 uc007rxj.3 
ENSMUST00000091227.9 Qrfpr ENSMUST00000091227.9 pyroglutamylated RFamide peptide receptor (from RefSeq NM_198192.3) ENSMUST00000091227.1 ENSMUST00000091227.2 ENSMUST00000091227.3 ENSMUST00000091227.4 ENSMUST00000091227.5 ENSMUST00000091227.6 ENSMUST00000091227.7 ENSMUST00000091227.8 Gpr103 NM_198192 Q4VA00 Q4VA00_MOUSE Qrfpr uc008ozh.1 uc008ozh.2 uc008ozh.3 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity neuropeptide Y receptor activity signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway membrane integral component of membrane uc008ozh.1 uc008ozh.2 uc008ozh.3 
ENSMUST00000091233.7 Adamtsl2 ENSMUST00000091233.7 ADAMTS-like 2 (from RefSeq NM_029981.2) ATL2_MOUSE ENSMUST00000091233.1 ENSMUST00000091233.2 ENSMUST00000091233.3 ENSMUST00000091233.4 ENSMUST00000091233.5 ENSMUST00000091233.6 Kiaa0605 NM_029981 Q3U0C8 Q7TSK7 Tcp1 uc008ixa.1 uc008ixa.2 uc008ixa.3 Interacts with LTBP1. Q7TSK7; P28301: Lox; NbExp=3; IntAct=EBI-25406979, EBI-642911; Q7TSK7; P58215: LOXL3; Xeno; NbExp=2; IntAct=EBI-25406979, EBI-723960; Secreted Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1- X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family. extracellular region proteolysis peptidase activity extracellular matrix organization negative regulation of transforming growth factor beta receptor signaling pathway extracellular matrix microfibril binding lobar bronchus epithelium development uc008ixa.1 uc008ixa.2 uc008ixa.3 
ENSMUST00000091257.11 Mfn1 ENSMUST00000091257.11 mitofusin 1 (from RefSeq NM_024200.5) ENSMUST00000091257.1 ENSMUST00000091257.10 ENSMUST00000091257.2 ENSMUST00000091257.3 ENSMUST00000091257.4 ENSMUST00000091257.5 ENSMUST00000091257.6 ENSMUST00000091257.7 ENSMUST00000091257.8 ENSMUST00000091257.9 MFN1_MOUSE NM_024200 Q3URC4 Q811D5 Q811U4 Q8CEY6 Q99M10 Q9D395 uc008owi.1 uc008owi.2 uc008owi.3 uc008owi.4 Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:23921378, PubMed:24513856, PubMed:15297672). Membrane clustering requires GTPase activity (By similarity). It may involve a major rearrangement of the coiled coil domains (PubMed:15297672). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12527753). Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; Homodimer, also in the absence of bound GTP (By similarity). Forms higher oligomers in the presence of a transition state GTP analog (By similarity). Forms homomultimers and heteromultimers with MFN2 (PubMed:12527753). Oligomerization is essential for mitochondrion fusion (PubMed:15297672). Component of a high molecular weight multiprotein complex (By similarity). Interacts with VAT1 (By similarity). Interacts with THG1L; THG1L probably functions as a guanyl-nucleotide exchange factor/GEF, activating MFN1. Q811U4; Q5S007: LRRK2; Xeno; NbExp=3; IntAct=EBI-9029118, EBI-5323863; Mitochondrion outer membrane ; Multi-pass membrane protein Detected in adult heart (PubMed:12759376). Detected in embryos (at protein level) (PubMed:12527753). Widely expressed (PubMed:11950885). Expressed in 8.5 dpc, 9.5 dpc, 10.5 dpc and 11.5 dpc embryos. A helix bundle is formed by helices from the N-terminal and the C-terminal part of the protein. The GTPase domain cannot be expressed by itself, without the helix bundle. Rearrangement of the helix bundle and/or of the coiled coil domains may bring membranes from adjacent mitochondria into close contact, and thereby play a role in mitochondrial fusion. Ubiquitinated by MARCHF5 (By similarity). When mitochondria are depolarized and dysfunctional, it is ubiquitinated by a SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complex that contains FBXO7 and PRKN. Ubiquitinated by non-degradative ubiquitin by PRKN, promoting mitochondrial fusion; deubiquitination by USP30 inhibits mitochondrial fusion (PubMed:24513856). Full embryonic lethality; nearly 90% of the mutant embryos have been resorbed at 11.5 dpc (PubMed:12527753). Contrary to wild-type embryonic fibroblasts that have elongated, tubular mitochondria, mutant embryonic fibroblasts contain only fragmented mitochondria (PubMed:12527753). In cultured cells, mutant mitochondria show a strongly decreased frequency of mitochondrial fusion events (PubMed:12527753). In spite of the aberrant mitochondrial morphology, there seem to be no gross defects in respiration (PubMed:12527753). Heart-specific disruption of Mfn1 does not impair heart function and has no effect on cardiomyocyte mitochondrial morphometry or respiratory function (PubMed:23620051). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. Sequence=AAH47050.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC25260.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding GTPase activity protein binding GTP binding mitochondrion mitochondrial outer membrane mitochondrial inner membrane multicellular organism development mitochondrial fusion positive regulation of mitochondrial fusion membrane integral component of membrane hydrolase activity intrinsic component of mitochondrial outer membrane integral component of mitochondrial outer membrane identical protein binding protein homodimerization activity GTP metabolic process intracellular distribution of mitochondria mitochondrion localization positive regulation of dendritic spine morphogenesis mitochondrion morphogenesis negative regulation of mitochondrial fission outer mitochondrial membrane protein complex mitochondrial membrane fusion uc008owi.1 uc008owi.2 uc008owi.3 uc008owi.4 
ENSMUST00000091259.9 Slc7a14 ENSMUST00000091259.9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 14 (from RefSeq NM_172861.3) ENSMUST00000091259.1 ENSMUST00000091259.2 ENSMUST00000091259.3 ENSMUST00000091259.4 ENSMUST00000091259.5 ENSMUST00000091259.6 ENSMUST00000091259.7 ENSMUST00000091259.8 Kiaa1613 NM_172861 Q69ZE9 Q8BXR1 S7A14_MOUSE Slc7a14 uc008ovx.1 uc008ovx.2 uc008ovx.3 uc008ovx.4 uc008ovx.5 Imports 4-aminobutanoate (GABA) into lysosomes. May act as a GABA sensor that regulates mTORC2-dependent INS signaling and gluconeogenesis. The transport mechanism and substrate selectivity remain to be elucidated. Reaction=4-aminobutanoate(in) = 4-aminobutanoate(out); Xref=Rhea:RHEA:35035, ChEBI:CHEBI:59888; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:35037; Evidence=; Lysosome membrane ; Multi-pass membrane protein Note=Exhibits a punctated pattern in the cytoplasm, which partially ovelaps with lysosomes. Expressed in retina, brain and spinal cord. In the retina, expressed in the inner nuclear layer and photoreceptor layer (at protein level) (PubMed:24670872). Expressed in liver, spleen, lung, kidney intestine and brain (at protein level) (PubMed:36640347). Detected in the eyeball at 18.5 dpc. Expression increases in the retina after birth from P4 to P90. Up-regulated in liver in response to high-fat diet. Mutant mice exhibit slightly thinner retina, including outer retinal layer, and abnormal electroretinography at 2 and 6 months of age compared to wild-type animals. They are viable and fertile. They do not show any noticeable physical abnormalities. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Sequence=BAD32495.1; Type=Erroneous initiation; Evidence=; lysosome lysosomal membrane amino acid transport negative regulation of phosphatase activity membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008ovx.1 uc008ovx.2 uc008ovx.3 uc008ovx.4 uc008ovx.5 
ENSMUST00000091270.3 Gm10258 ENSMUST00000091270.3 Gm10258 (from geneSymbol) AY512924 ENSMUST00000091270.1 ENSMUST00000091270.2 uc290ehc.1 uc290ehc.2 uc290ehc.1 uc290ehc.2 
ENSMUST00000091278.6 Lcn11 ENSMUST00000091278.6 lipocalin 11 (from RefSeq NM_001100455.2) A2BHR2 A2BHR2_MOUSE ENSMUST00000091278.1 ENSMUST00000091278.2 ENSMUST00000091278.3 ENSMUST00000091278.4 ENSMUST00000091278.5 Lcn11 NM_001100455 uc008itj.1 uc008itj.2 uc008itj.3 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc008itj.1 uc008itj.2 uc008itj.3 
ENSMUST00000091282.5 Fnd3c2 ENSMUST00000091282.5 fibronectin type III domain containing 3C2 (from RefSeq NM_001033424.3) A2AP83 A2AP83_MOUSE ENSMUST00000091282.1 ENSMUST00000091282.2 ENSMUST00000091282.3 ENSMUST00000091282.4 Fnd3c2 NM_001033424 uc009ubr.1 uc009ubr.2 uc009ubr.3 molecular_function cellular_component biological_process membrane integral component of membrane uc009ubr.1 uc009ubr.2 uc009ubr.3 
ENSMUST00000091288.13 Prnp ENSMUST00000091288.13 prion protein, transcript variant 1 (from RefSeq NM_011170.3) ENSMUST00000091288.1 ENSMUST00000091288.10 ENSMUST00000091288.11 ENSMUST00000091288.12 ENSMUST00000091288.2 ENSMUST00000091288.3 ENSMUST00000091288.4 ENSMUST00000091288.5 ENSMUST00000091288.6 ENSMUST00000091288.7 ENSMUST00000091288.8 ENSMUST00000091288.9 NM_011170 Prnp Q4FJQ7 Q4FJQ7_MOUSE uc008mly.1 uc008mly.2 uc008mly.3 uc008mly.4 uc008mly.5 Cell membrane ; Lipid-anchor, GPI-anchor Golgi apparatus Membrane ; Lipid-anchor, GPI-anchor Belongs to the prion family. beta-amyloid binding copper ion binding lamin binding cytoplasm cytosol plasma membrane learning or memory microtubule binding cell surface postsynaptic density tubulin binding membrane integral component of membrane inclusion body dendrite protein destabilization type 5 metabotropic glutamate receptor binding nuclear membrane calcium-mediated signaling using intracellular calcium source identical protein binding ATP-dependent protein binding negative regulation of apoptotic process negative regulation of catalytic activity intracellular membrane-bounded organelle positive regulation of neuron apoptotic process ion channel binding macromolecular complex binding membrane raft response to cadmium ion response to copper ion metal ion binding positive regulation of peptidyl-tyrosine phosphorylation chaperone binding protein homooligomerization positive regulation of protein tyrosine kinase activity cellular response to copper ion negative regulation of long-term synaptic potentiation regulation of intracellular calcium activated chloride channel activity positive regulation of protein localization to plasma membrane cuprous ion binding cellular response to beta-amyloid uc008mly.1 uc008mly.2 uc008mly.3 uc008mly.4 uc008mly.5 
ENSMUST00000091291.5 Insr ENSMUST00000091291.5 insulin receptor, transcript variant 1 (from RefSeq NM_010568.3) ENSMUST00000091291.1 ENSMUST00000091291.2 ENSMUST00000091291.3 ENSMUST00000091291.4 F8VPU4 INSR_MOUSE NM_010568 P15208 uc009krd.1 uc009krd.2 uc009krd.3 This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis. [provided by RefSeq, Aug 2016]. Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras- MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin- stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). When present in a hybrid receptor with IGF1R, binds IGF1 (By similarity). In adipocytes, inhibits lipolysis (PubMed:27322061). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Activated in response to insulin. Autophosphorylation activates the kinase activity. PTPN1, PTPRE and PTPRF dephosphorylate important tyrosine residues, thereby reducing INSR activity. Inhibited by ENPP1. GRB10 and GRB14 inhibit the catalytic activity of the INSR, they block access of substrates to the activated receptor. SOCS1 and SOCS3 act as negative regulators of INSR activity, they bind to the activated INRS and interfere with the phosphorylation of INSR substrates (By similarity). Interacts with PTPRF (By similarity). Interacts with ATIC; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling netwok regulating INSR autophosphorylation and endocytosis (By similarity). Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with SORBS1 but dissociates from it following insulin stimulation. Binds SH2B2 (By similarity). Activated form of INSR interacts (via Tyr- 989) with the PTB/PID domains of IRS1 and SHC1. The sequences surrounding the phosphorylated NPXY motif contribute differentially to either IRS1 or SHC1 recognition. Interacts (via tyrosines in the C- terminus) with IRS2 (via PTB domain and 591-786 AA); the 591-786 would be the primary anchor of IRS2 to INSR while the PTB domain would have a stabilizing action on the interaction with INSR. Interacts with the SH2 domains of the 85 kDa regulatory subunit of PI3K (PIK3R1) in vitro, when autophosphorylated on tyrosine residues. Interacts with SOCS7 (By similarity). Interacts (via the phosphorylated Tyr-989), with SOCS3. Interacts (via the phosphorylated Tyr-1175, Tyr-1179, Tyr-1180) with SOCS1. Interacts with CAV2 (tyrosine-phosphorylated form); the interaction is increased with 'Tyr-27'phosphorylation of CAV2 (By similarity). Interacts with ARRB2. Interacts with GRB10; this interaction blocks the association between IRS1/IRS2 and INSR, significantly reduces insulin-stimulated tyrosine phosphorylation of IRS1 and IRS2 and thus decreases insulin signaling (By similarity). Interacts with GRB7 (By similarity). Interacts with PDPK1 (By similarity). Interacts (via Tyr-1180) with GRB14 (via BPS domain); this interaction protects the tyrosines in the activation loop from dephosphorylation, but promotes dephosphorylation of Tyr-989, this results in decreased interaction with, and phosphorylation of, IRS1 (By similarity). Interacts (via subunit alpha) with ENPP1 (via 485-599 AA); this interaction blocks autophosphorylation (By similarity). Interacts with PTPRE; this interaction is dependent of Tyr-1175, Tyr-1179 and Tyr-1180 of the INSR (By similarity). Interacts with STAT5B (via SH2 domain) (By similarity). Interacts with PTPRF (By similarity). Interacts with the insulin receptor SORL1; this interaction strongly increases its surface exposure, hence strengthens insulin signal reception (PubMed:27322061). Interacts (tyrosine phosphorylated) with CCDC88A/GIV (via SH2-like region); binding requires autophosphorylation of the INSR C-terminal region (By similarity). Interacts with GNAI3; the interaction is probably mediated by CCDC88A/GIV (By similarity). Interacts with LMBRD1 (PubMed:24078630). Interacts (in response to insulin stimulation) with NCK1; this interaction may recruit PTPN1 to mediate INSR dephosphorylation (By similarity). P15208; P49817: Cav1; NbExp=2; IntAct=EBI-6999015, EBI-1161338; P15208; Q60760: Grb10; NbExp=6; IntAct=EBI-6999015, EBI-861810; P15208; Q1XH17: Trim72; NbExp=2; IntAct=EBI-6999015, EBI-16034016; Cell membrane ; Single-pass type I membrane protein Recycling endosome membrane Late endosome Lysosome Note=Binding of insulin to INSR induces internalization and lysosomal degradation of the receptor, a means for down-regulating this signaling pathway after stimulation. In the presence of SORL1, internalized INSR molecules are redirected back to the cell surface, thereby preventing their lysosomal catabolism and strengthening insulin signal reception. The tetrameric insulin receptor binds insulin via non-identical regions from two alpha chains, primarily via the C-terminal region of the first INSR alpha chain. Residues from the leucine-rich N-terminus of the other INSR alpha chain also contribute to this insulin binding site. A secondary insulin-binding site is formed by residues at the junction of fibronectin type-III domain 1 and 2 (By similarity). Autophosphorylated on tyrosine residues in response to insulin (By similarity). Phosphorylation of Tyr-989 is required for IRS1-, SHC1-, and STAT5B-binding (By similarity). Dephosphorylated by PTPRE on Tyr- 989, Tyr-1175, Tyr-1179 and Tyr-1180 residues (By similarity). Dephosphorylated by PTPRF and PTPN1 (By similarity). Dephosphorylated by PTPN2 and Ptprv; down-regulates insulin-induced signaling (PubMed:12612081, PubMed:20655470). Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. nucleotide binding activation of MAPK activity beta-amyloid binding negative regulation of protein phosphorylation positive regulation of protein phosphorylation heart morphogenesis protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor receptor binding protein binding ATP binding GTP binding nucleus nuclear envelope lysosome endosome late endosome cytosol plasma membrane integral component of plasma membrane insulin receptor complex caveola regulation of transcription, DNA-templated protein phosphorylation receptor-mediated endocytosis transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled receptor signaling pathway positive regulation of cell proliferation insulin receptor signaling pathway epidermis development male gonad development animal organ morphogenesis external side of plasma membrane regulation of hydrogen peroxide metabolic process positive regulation of glycoprotein biosynthetic process negative regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation transformation of host cell by virus protein kinase binding protein phosphatase binding protein domain specific binding male sex determination adrenal gland development positive regulation of cell migration axon exocrine pancreas development lipoic acid binding nuclear lumen insulin-like growth factor I binding insulin-like growth factor II binding activation of protein kinase activity activation of protein kinase B activity negative regulation of transporter activity dendrite membrane neuronal cell body membrane cellular response to insulin stimulus response to tumor necrosis factor cargo receptor activity peptidyl-tyrosine autophosphorylation positive regulation of phosphorylation glucose homeostasis identical protein binding neuronal cell body intracellular membrane-bounded organelle receptor complex positive regulation of protein complex disassembly positive regulation of MAPK cascade 3-phosphoinositide-dependent protein kinase binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding macromolecular complex binding synapse positive regulation of nitric oxide biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of glycolytic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated regulation of embryonic development positive regulation of glucose import protein autophosphorylation positive regulation of developmental growth anatomical structure development protein heterotetramerization PTB domain binding positive regulation of meiotic cell cycle positive regulation of protein kinase B signaling recycling endosome membrane positive regulation of respiratory burst cellular response to growth factor stimulus dendritic spine maintenance beta-amyloid clearance neuron projection maintenance regulation of female gonad development uc009krd.1 uc009krd.2 uc009krd.3 
ENSMUST00000091299.8 Cdk7 ENSMUST00000091299.8 cyclin dependent kinase 7 (from RefSeq NM_009874.4) Cdk7 ENSMUST00000091299.1 ENSMUST00000091299.2 ENSMUST00000091299.3 ENSMUST00000091299.4 ENSMUST00000091299.5 ENSMUST00000091299.6 ENSMUST00000091299.7 NM_009874 Q3THG5 Q3THG5_MOUSE uc007rrk.1 uc007rrk.2 uc007rrk.3 uc007rrk.4 uc007rrk.5 Reaction=[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho- [DNA-directed RNA polymerase]; Xref=Rhea:RHEA:10216, Rhea:RHEA- COMP:11321, Rhea:RHEA-COMP:11322, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.23; Evidence=; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus holo TFIIH complex transcription from RNA polymerase II promoter protein phosphorylation protein C-terminus binding DNA-dependent ATPase activity RNA polymerase II carboxy-terminal domain kinase activity kinase activity phosphorylation cyclin-dependent protein kinase activating kinase holoenzyme complex positive regulation of transcription from RNA polymerase II promoter protein stabilization TFIIK complex uc007rrk.1 uc007rrk.2 uc007rrk.3 uc007rrk.4 uc007rrk.5 
ENSMUST00000091309.12 Cp ENSMUST00000091309.12 ceruloplasmin, transcript variant 2 (from RefSeq NM_007752.4) CERU_MOUSE ENSMUST00000091309.1 ENSMUST00000091309.10 ENSMUST00000091309.11 ENSMUST00000091309.2 ENSMUST00000091309.3 ENSMUST00000091309.4 ENSMUST00000091309.5 ENSMUST00000091309.6 ENSMUST00000091309.7 ENSMUST00000091309.8 ENSMUST00000091309.9 NM_007752 Q61147 Q6P5C8 uc008orz.1 uc008orz.2 uc008orz.3 uc008orz.4 The protein encoded by this gene is a copper-containing glycoprotein found soluble in the serum and GPI-anchored in other tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an important role in iron homeostasis. In humans mutations of this gene cause aceruloplasminemia, which is characterized by retinal degeneration, diabetes, anemia and neurological symptoms. In mouse deficiency of this gene in combination with a deficiency of its homolog hephaestin causes retinal degeneration and serves as a pathophysiological model for aceruloplasminemia and age-related macular degeneration. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity). Reaction=4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O; Xref=Rhea:RHEA:11148, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.16.3.1; Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Note=Binds 6 Cu cations per monomer. ; Secreted. Note=Colocalizes with GCP1 in secretory intracellular compartments. Expressed in many tissues, including liver, eye and brain. Belongs to the multicopper oxidase family. ferroxidase activity copper ion binding extracellular region extracellular space plasma membrane ion transport copper ion transport iron ion transport cellular iron ion homeostasis oxidoreductase activity anchored component of plasma membrane response to copper ion metal ion binding chaperone binding iron ion homeostasis oxidation-reduction process uc008orz.1 uc008orz.2 uc008orz.3 uc008orz.4 
ENSMUST00000091318.5 Rnf224 ENSMUST00000091318.5 ring finger protein 224 (from RefSeq NM_001033410.3) ENSMUST00000091318.1 ENSMUST00000091318.2 ENSMUST00000091318.3 ENSMUST00000091318.4 Gm757 NM_001033410 Q3UIW8 RN224_MOUSE uc008iqu.1 uc008iqu.2 metal ion binding uc008iqu.1 uc008iqu.2 
ENSMUST00000091319.7 Sirpb1b ENSMUST00000091319.7 signal-regulatory protein beta 1B (from RefSeq NM_001173460.1) ENSMUST00000091319.1 ENSMUST00000091319.2 ENSMUST00000091319.3 ENSMUST00000091319.4 ENSMUST00000091319.5 ENSMUST00000091319.6 NM_001173460 Q3U390 Q3U390_MOUSE Sirpb1 Sirpb1b uc008ora.1 uc008ora.2 uc008ora.3 molecular_function plasma membrane membrane integral component of membrane positive regulation of cell-cell adhesion positive regulation of phagocytosis positive regulation of T cell activation uc008ora.1 uc008ora.2 uc008ora.3 
ENSMUST00000091364.5 1700008P02Rik ENSMUST00000091364.5 1700008P02Rik (from geneSymbol) AK005786 ENSMUST00000091364.1 ENSMUST00000091364.2 ENSMUST00000091364.3 ENSMUST00000091364.4 uc008ooe.1 uc008ooe.2 uc008ooe.3 uc008ooe.4 uc008ooe.5 uc008ooe.1 uc008ooe.2 uc008ooe.3 uc008ooe.4 uc008ooe.5 
ENSMUST00000091374.9 Sumo1 ENSMUST00000091374.9 small ubiquitin-like modifier 1 (from RefSeq NM_009460.2) ENSMUST00000091374.1 ENSMUST00000091374.2 ENSMUST00000091374.3 ENSMUST00000091374.4 ENSMUST00000091374.5 ENSMUST00000091374.6 ENSMUST00000091374.7 ENSMUST00000091374.8 NM_009460 P55856 P63166 Q3TX92 Q93068 SUMO1_MOUSE Smt3c Smt3h3 Ubl1 uc007bdx.1 uc007bdx.2 Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (By similarity). Covalently attached to KCNB1; UBE2I increases cross-linking with KCNB1 and PIAS1 decreases cross-links with KCNB1 (By similarity). Interacts with SAE2, RANBP2, PIAS1 and PIAS2 (By similarity). Interacts with PRKN (By similarity). Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG (By similarity). Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52 (By similarity). Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25 (By similarity). Interacts with SIMC1, CASP8AP2, RNF111 and SOBP (via SIM domains) (By similarity). Interacts with BHLHE40/DEC1 (By similarity). Interacts with RWDD3 (By similarity). Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3 (By similarity). Interacts with MTA1 (By similarity). Interacts with SENP2 (By similarity). Interacts with HINT1 (PubMed:31088288). P63166; Q03267: Ikzf1; NbExp=2; IntAct=EBI-80152, EBI-908572; P63166; Q505F1: Nr2c1; NbExp=5; IntAct=EBI-80152, EBI-15617004; P63166; P63015: Pax6; NbExp=2; IntAct=EBI-80152, EBI-1395428; P63166; P26367-1: PAX6; Xeno; NbExp=2; IntAct=EBI-80152, EBI-15892945; P63166; P18031: PTPN1; Xeno; NbExp=2; IntAct=EBI-80152, EBI-968788; Nucleus membrane Nucleus speckle Cytoplasm Nucleus, PML body Cell membrane Nucleus Note=Recruited by BCL11A into the nuclear body (PubMed:18681895). In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body (By similarity). Ubiquitous. Expressed at 13.5 dpc strongly in the upper lip, primary palate and medial edge epithelia of the secondary palate. At 14.5 dpc expression could be seen in the medial edge epithelial seam. By hypoxia. Cleavage of precursor form by SENP1 or SENP2 is necessary for function. Polymeric SUMO1 chains undergo polyubiquitination by RNF4. Belongs to the ubiquitin family. SUMO subfamily. heterochromatin transcription corepressor binding fibrillar center XY body protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol plasma membrane regulation of transcription, DNA-templated protein C-terminus binding voltage-gated potassium channel complex transcription factor binding potassium channel regulator activity membrane nuclear body PML body nuclear speck protein sumoylation enzyme binding dendrite PML body organization protein binding, bridging positive regulation of protein complex assembly protein tag SUMO activating enzyme complex ubiquitin protein ligase binding regulation of protein stability nuclear membrane positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to heat glucocorticoid receptor binding negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity small protein activating enzyme binding ubiquitin-like protein ligase binding synapse negative regulation of action potential negative regulation of transcription, DNA-templated protein stabilization palate development cellular response to cadmium ion regulation of cardiac muscle cell contraction protein localization to nuclear pore nuclear stress granule positive regulation of calcium-transporting ATPase activity negative regulation of delayed rectifier potassium channel activity regulation of calcium ion transmembrane transport uc007bdx.1 uc007bdx.2 
ENSMUST00000091377.5 1700029F12Rik ENSMUST00000091377.5 RIKEN cDNA 1700029F12 gene, transcript variant 2 (from RefSeq NM_025585.3) 1700029F12Rik ENSMUST00000091377.1 ENSMUST00000091377.2 ENSMUST00000091377.3 ENSMUST00000091377.4 NM_025585 Q9CRB4 Q9CRB4_MOUSE uc007rnp.1 uc007rnp.2 molecular_function cellular_component biological_process uc007rnp.1 uc007rnp.2 
ENSMUST00000091403.6 Arsb ENSMUST00000091403.6 arylsulfatase B (from RefSeq NM_009712.3) A0A0R4J138 A0A0R4J138_MOUSE Arsb ENSMUST00000091403.1 ENSMUST00000091403.2 ENSMUST00000091403.3 ENSMUST00000091403.4 ENSMUST00000091403.5 NM_009712 uc007rlo.1 uc007rlo.2 uc007rlo.3 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Belongs to the sulfatase family. catalytic activity N-acetylgalactosamine-4-sulfatase activity mitochondrion lysosome rough endoplasmic reticulum Golgi apparatus autophagy central nervous system development response to nutrient sulfuric ester hydrolase activity response to pH cell surface regulation of epithelial cell migration positive regulation of neuron projection development response to estrogen response to methylmercury colon epithelial cell migration uc007rlo.1 uc007rlo.2 uc007rlo.3 
ENSMUST00000091418.12 Dnajc1 ENSMUST00000091418.12 DnaJ heat shock protein family (Hsp40) member C1, transcript variant 2 (from RefSeq NM_001190817.2) DNJC1_MOUSE Dnajl1 ENSMUST00000091418.1 ENSMUST00000091418.10 ENSMUST00000091418.11 ENSMUST00000091418.2 ENSMUST00000091418.3 ENSMUST00000091418.4 ENSMUST00000091418.5 ENSMUST00000091418.6 ENSMUST00000091418.7 ENSMUST00000091418.8 ENSMUST00000091418.9 Mtj1 NM_001190817 Q61712 uc008ilt.1 uc008ilt.2 uc008ilt.3 uc008ilt.4 May modulate protein synthesis. Interacts (via J domain) with HSPA5. Interacts (via cytosolic domain) with ribosomes. Interacts (via SANT 2 domain) with SERPINA3; the interaction delays the formation of the covalent inhibitory complex SERPINA3-chymotrypsin, but does not alter the catalytic activity of SERPINA3. Interacts (via SANT 2 domain) with ITIH4 (via C-terminus); the interaction protects ITIH4 against in vitro cleavage by kallikrein (By similarity). Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein. Widely expressed. DNA binding protein binding nucleus endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane plasma membrane regulation of translation protein folding membrane integral component of membrane organelle membrane nuclear membrane ribosome binding intracellular membrane-bounded organelle regulation of protein secretion chaperone binding uc008ilt.1 uc008ilt.2 uc008ilt.3 uc008ilt.4 
ENSMUST00000091420.6 Skida1 ENSMUST00000091420.6 SKI/DACH domain containing 1 (from RefSeq NM_028317.4) 2810030E01Rik ENSMUST00000091420.1 ENSMUST00000091420.2 ENSMUST00000091420.3 ENSMUST00000091420.4 ENSMUST00000091420.5 G3X9M2 G3X9M2_MOUSE NM_028317 Skida1 uc008ill.1 uc008ill.2 uc008ill.3 uc008ill.1 uc008ill.2 uc008ill.3 
ENSMUST00000091436.7 Cubn ENSMUST00000091436.7 cubilin (from RefSeq NM_001081084.2) B1AX10 CUBN_MOUSE ENSMUST00000091436.1 ENSMUST00000091436.2 ENSMUST00000091436.3 ENSMUST00000091436.4 ENSMUST00000091436.5 ENSMUST00000091436.6 Ifcr NM_001081084 Q9JLB4 uc008ijz.1 uc008ijz.2 uc008ijz.3 Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri- implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. Interacts with AMN. Component of the cubam complex composed of one CUBN trimer and one AMN chain (By similarity). The cubam complex can dimerize (By similarity). Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner. Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and PID1/PCLI1 (By similarity). Apical cell membrane ; Peripheral membrane protein Cell membrane ; Peripheral membrane protein Membrane, coated pit Endosome Lysosome membrane ; Peripheral membrane protein Note=Lacks a transmembrane domain and depends on interaction with AMN for location at the plasma membrane (By similarity). Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells (By similarity). Expressed in kidney, thymus, ileum, placenta, small intestine and yolk sac. In kidney expressed on the apical brush border surface of proximal tubular cells, in particular in endosomes and recycling membranes vesicles, so-called dense apical tubules, which carry internalized receptors back to the cell surface. Expressed in fetal membranes of yolk sac, placenta of pregnant females. Detected in yolk sac endoderm as early as day 6 and is present at the apical surface of those cells throughout the remainder of pregnancy. Apical expression is pronounced in the extraembryonic visceral endoderm (VE) of 6-9.5 dpc. Expressed by a subpopulation of cells dispersed within the 7.5 dpc embryonic endoderm and having a migratory morphology. First detected at the eight-cell stage. At the 32-cell stage expressed in all outer cells which are at the origin of the trophectoderm (TE). During the blastocyst stage, expression is predominant at the apical membrane of the TE cells. The CUB domains 5 to 8 mediate binding to CBLIF and ALB. CUB domains 1 and 2 mediate interaction with LRP2. The cubam complex is composed of a 400 Angstrom long stem and a globular crown region. The stem region is probably formed by AMN and the CUBN N-terminal region, including the EGF-like domains. The crown is probably formed by the CUBN CUB domains. The precursor is cleaved by a trans-Golgi proteinase furin, removing a propeptide. N-glycosylated. in utero embryonic development calcium ion binding protein binding cytoplasm lysosome lysosomal membrane endosome endoplasmic reticulum Golgi apparatus Golgi-associated vesicle plasma membrane brush border clathrin-coated pit lipid metabolic process receptor-mediated endocytosis response to nutrient drug binding steroid metabolic process cholesterol metabolic process response to bacterium protein transport cobalamin transport membrane apical plasma membrane hemoglobin import coated vesicle endocytic vesicle hemoglobin binding endocytic vesicle membrane cobalamin binding brush border membrane macromolecular complex signaling receptor activity cargo receptor activity cobalamin catabolic process identical protein binding protein homodimerization activity lipoprotein transport lysosomal lumen apical part of cell metal ion binding extracellular exosome protein homotrimerization uc008ijz.1 uc008ijz.2 uc008ijz.3 
ENSMUST00000091440.4 Zscan4-ps2 ENSMUST00000091440.4 Chromosome, telomere Nucleus (from UniProt A0A1C7CYU6) A0A1C7CYU6 A0A1C7CYU6_MOUSE AK141250 ENSMUST00000091440.1 ENSMUST00000091440.2 ENSMUST00000091440.3 Zscan4-ps2 uc291llh.1 uc291llh.2 Chromosome, telomere Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc291llh.1 uc291llh.2 
ENSMUST00000091458.13 Nr2f1 ENSMUST00000091458.13 nuclear receptor subfamily 2, group F, member 1, transcript variant 1 (from RefSeq NM_010151.4) ENSMUST00000091458.1 ENSMUST00000091458.10 ENSMUST00000091458.11 ENSMUST00000091458.12 ENSMUST00000091458.2 ENSMUST00000091458.3 ENSMUST00000091458.4 ENSMUST00000091458.5 ENSMUST00000091458.6 ENSMUST00000091458.7 ENSMUST00000091458.8 ENSMUST00000091458.9 NM_010151 Nr2f1 Q32NY6 Q32NY6_MOUSE uc007rhe.1 uc007rhe.2 uc007rhe.3 uc007rhe.4 Nucleus Belongs to the nuclear hormone receptor family. NR2 subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity nucleus nucleoplasm cytosol regulation of transcription, DNA-templated nervous system development zinc ion binding negative regulation of neuron projection development steroid hormone mediated signaling pathway sequence-specific DNA binding retinoic acid-responsive element binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc007rhe.1 uc007rhe.2 uc007rhe.3 uc007rhe.4 
ENSMUST00000091493.6 Zdhhc11 ENSMUST00000091493.6 zinc finger, DHHC domain containing 11, transcript variant 1 (from RefSeq NM_027704.3) ENSMUST00000091493.1 ENSMUST00000091493.2 ENSMUST00000091493.3 ENSMUST00000091493.4 ENSMUST00000091493.5 NM_027704 Q14AK4 Q5Y5T4 ZDH11_MOUSE Zdhhc11 uc007ren.1 uc007ren.2 uc007ren.3 Endoplasmic reticulum-localized palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (PubMed:23687301). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (PubMed:23687301). May play a role in cell proliferation (By similarity). Has also a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response (PubMed:29429998). Functions as an adapter that recruits IRF3 to STING1 to promote the activation of that key transcriptional regulator of type I interferon (IFN)-dependent immune response (PubMed:29429998). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Interacts with IRF3 and STING1; in presence of DNA viruses recruits IRF3 to STING1 promoting IRF3 phosphorylation and activation. Endosome membrane ; Multi-pass membrane protein The DHHC domain is required for palmitoyltransferase activity. Homozygous knockout mice are viable and do not show overt phenotype (PubMed:29429998). Composition and number of major immune cells is normal but mice are more susceptible to DNA-virus infection and death than their wild-type counterpart (PubMed:29429998). Belongs to the DHHC palmitoyltransferase family. endoplasmic reticulum Golgi apparatus protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein-cysteine S-palmitoyltransferase activity uc007ren.1 uc007ren.2 uc007ren.3 
ENSMUST00000091497.11 Frmd4a ENSMUST00000091497.11 FERM domain containing 4A, transcript variant 1 (from RefSeq NM_172475.3) B1AXK1 B1AXK2 ENSMUST00000091497.1 ENSMUST00000091497.10 ENSMUST00000091497.2 ENSMUST00000091497.3 ENSMUST00000091497.4 ENSMUST00000091497.5 ENSMUST00000091497.6 ENSMUST00000091497.7 ENSMUST00000091497.8 ENSMUST00000091497.9 FRM4A_MOUSE Frmd4 Kiaa1294 NM_172475 Q6PDJ4 Q8BIE6 Q8CHA6 uc008ieo.1 uc008ieo.2 uc008ieo.3 uc008ieo.4 Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (PubMed:20080746). Plays a redundant role with FRMD4B in epithelial polarization (PubMed:20080746). May regulate MAPT secretion by activating ARF6- signaling (By similarity). Interacts (via coiled-coil domain) with CYTH1 (via coiled-coil domain) (PubMed:20080746). Interacts with PARD3 (via coiled-coil domain) (PubMed:20080746). Found in a complex with PARD3, CYTH1 and FRMD4A (PubMed:20080746). Interacts with CYTH2 (PubMed:20080746). Interacts with CYTH3 (PubMed:20080746). Cytoplasm, cytoskeleton Cell junction, adherens junction Cell junction, tight junction Note=Colocalized with CYTH1 at adherens junction and tight junction (PubMed:20080746). Colocalized with PARD3 during the process of epithelial polarization (PubMed:20080746). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BIE6-1; Sequence=Displayed; Name=2; IsoId=Q8BIE6-2; Sequence=VSP_035378, VSP_019592; Sequence=AAH58672.1; Type=Erroneous initiation; Evidence=; Sequence=CAM46015.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM46271.1; Type=Erroneous gene model prediction; Evidence=; cytoplasm cytoskeleton adherens junction bicellular tight junction cell junction protein binding, bridging negative regulation of protein secretion positive regulation of protein secretion establishment of epithelial cell polarity uc008ieo.1 uc008ieo.2 uc008ieo.3 uc008ieo.4 
ENSMUST00000091514.6 Srd5a1 ENSMUST00000091514.6 steroid 5 alpha-reductase 1 (from RefSeq NM_175283.3) A0A0R4J136 A0A0R4J136_MOUSE ENSMUST00000091514.1 ENSMUST00000091514.2 ENSMUST00000091514.3 ENSMUST00000091514.4 ENSMUST00000091514.5 NM_175283 Srd5a1 uc007rck.1 uc007rck.2 uc007rck.3 Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Reaction=17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = H(+) + NADPH + testosterone; Xref=Rhea:RHEA:50820, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:17347, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.22; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50822; Evidence=; Reaction=5alpha-pregnane-3,20-dione + NADP(+) = H(+) + NADPH + progesterone; Xref=Rhea:RHEA:21952, ChEBI:CHEBI:15378, ChEBI:CHEBI:17026, ChEBI:CHEBI:28952, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.22; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21954; Evidence=; Reaction=a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH; Xref=Rhea:RHEA:54384, ChEBI:CHEBI:13601, ChEBI:CHEBI:15378, ChEBI:CHEBI:47909, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.22; Evidence=; Reaction=androst-4-ene-3,17-dione + H(+) + NADPH = 5alpha- androstan-3,17-dione + NADP(+); Xref=Rhea:RHEA:50816, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:16422, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50817; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Microsome membrane ; Multi-pass membrane protein Belongs to the steroid 5-alpha reductase family. urogenital system development liver development 3-oxo-5-alpha-steroid 4-dehydrogenase activity cytoplasm lipid metabolic process steroid biosynthetic process androgen biosynthetic process androgen catabolic process steroid metabolic process androgen metabolic process male gonad development cellular response to starvation response to organic cyclic compound response to muscle activity membrane integral component of membrane diterpenoid metabolic process oxidoreductase activity, acting on the CH-CH group of donors spinal cord development hippocampus development thalamus development hypothalamus development pituitary gland development cerebral cortex development male genitalia development female genitalia development response to follicle-stimulating hormone response to estradiol cellular response to insulin stimulus amide binding response to testosterone serotonin metabolic process progesterone metabolic process response to drug circadian sleep/wake cycle, REM sleep neuronal cell body myelin sheath intracellular membrane-bounded organelle response to estrogen cholestenone 5-alpha-reductase activity perinuclear region of cytoplasm oxidation-reduction process bone development response to growth hormone response to fungicide NADPH binding cell body fiber cellular response to cAMP cellular response to growth factor stimulus cellular response to estradiol stimulus cellular response to testosterone stimulus cellular response to organic cyclic compound cellular response to dexamethasone stimulus cellular response to epinephrine stimulus uc007rck.1 uc007rck.2 uc007rck.3 
ENSMUST00000091526.4 Rslcan18 ENSMUST00000091526.4 regulator of sex-limitation candidate 18 (from RefSeq NM_001256052.1) BC038328 ENSMUST00000091526.1 ENSMUST00000091526.2 ENSMUST00000091526.3 NM_001256052 Q7M6X5 Q7M6X5_MOUSE Rslcan18 Zfp708 uc029sby.1 uc029sby.2 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc029sby.1 uc029sby.2 
ENSMUST00000091554.6 Cntnap3 ENSMUST00000091554.6 contactin associated protein-like 3 (from RefSeq NM_001081129.2) Cntnap3 E9PY62 E9PY62_MOUSE ENSMUST00000091554.1 ENSMUST00000091554.2 ENSMUST00000091554.3 ENSMUST00000091554.4 ENSMUST00000091554.5 NM_001081129 uc007qyz.1 uc007qyz.2 uc007qyz.3 Membrane ; Single- pass type I membrane protein Belongs to the neurexin family. Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function cellular_component biological_process membrane integral component of membrane uc007qyz.1 uc007qyz.2 uc007qyz.3 
ENSMUST00000091556.12 Btbd3 ENSMUST00000091556.12 BTB domain containing 3, transcript variant 2 (from RefSeq NM_001025431.1) Btbd3 ENSMUST00000091556.1 ENSMUST00000091556.10 ENSMUST00000091556.11 ENSMUST00000091556.2 ENSMUST00000091556.3 ENSMUST00000091556.4 ENSMUST00000091556.5 ENSMUST00000091556.6 ENSMUST00000091556.7 ENSMUST00000091556.8 ENSMUST00000091556.9 NM_001025431 Q3TSN9 Q3TSN9_MOUSE uc008mpa.1 uc008mpa.2 uc008mpa.3 uc008mpa.1 uc008mpa.2 uc008mpa.3 
ENSMUST00000091560.11 Aopep ENSMUST00000091560.11 aminopeptidase O, transcript variant 2 (from RefSeq NM_001289926.1) AMPO_MOUSE ENSMUST00000091560.1 ENSMUST00000091560.10 ENSMUST00000091560.2 ENSMUST00000091560.3 ENSMUST00000091560.4 ENSMUST00000091560.5 ENSMUST00000091560.6 ENSMUST00000091560.7 ENSMUST00000091560.8 ENSMUST00000091560.9 NM_001289926 Onpep Q3UQZ7 Q6P0W6 Q6P394 Q8BHX5 Q8BXQ6 uc007qxi.1 uc007qxi.2 uc007qxi.3 uc007qxi.4 Aminopeptidase which catalyzes the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Nucleus, nucleolus [Isoform 2]: Cytoplasm Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms may exist. ; Name=1; IsoId=Q8BXQ6-1; Sequence=Displayed; Name=2; IsoId=Q8BXQ6-3; Sequence=VSP_061019, VSP_061020; Expressed in testis, heart, brain, lung, liver, skeletal muscle, kidney and ovary. Expressed in vascular tissues. Belongs to the peptidase M1 family. A paper describing the expression patterns of this protein has been retracted due to concerns of image manipulation. Sequence=BAC36293.1; Type=Miscellaneous discrepancy; Note=Intron retention. This sequence is incomplete at the 5'-end and differs from that shown at positions 658-661.; Evidence=; aminopeptidase activity nucleus nucleolus cytoplasm proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding metalloaminopeptidase activity uc007qxi.1 uc007qxi.2 uc007qxi.3 uc007qxi.4 
ENSMUST00000091569.7 4930486L24Rik ENSMUST00000091569.7 RIKEN cDNA 4930486L24 gene (from RefSeq NM_178098.2) ENSMUST00000091569.1 ENSMUST00000091569.2 ENSMUST00000091569.3 ENSMUST00000091569.4 ENSMUST00000091569.5 ENSMUST00000091569.6 NM_178098 Q3UKN7 Q80UB0 TEST2_MOUSE uc007qvs.1 uc007qvs.2 uc007qvs.3 Secreted Expressed in testis and ovary. Low level in spleen, epididymis, kidney, and uterus. Expressed in primary cultures of Sertoli cells. Belongs to the peptidase C1 family. This protein is distinct from Tes/Testin which is a LIM domain protein. cysteine-type endopeptidase activity extracellular region extracellular space lysosome proteolysis cysteine-type peptidase activity cell junction proteolysis involved in cellular protein catabolic process uc007qvs.1 uc007qvs.2 uc007qvs.3 
ENSMUST00000091579.6 Gkap1 ENSMUST00000091579.6 G kinase anchoring protein 1 (from RefSeq NM_019832.4) ENSMUST00000091579.1 ENSMUST00000091579.2 ENSMUST00000091579.3 ENSMUST00000091579.4 ENSMUST00000091579.5 GKAP1_MOUSE Gkap42 NM_019832 Q9CUD8 Q9JMB0 uc007qtn.1 uc007qtn.2 uc007qtn.3 Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. Interacts with PRKG1 (PubMed:10671526). Interacts with IRS1 (PubMed:25586176). Golgi apparatus Predominantly expressed in testis. Expressed in the adipose tissue (at protein level) (PubMed:25586176). In the testis it is restricted to spermatocytes and early round spermatids. Also expressed in cardiac fibroblasts. Down-regulated by TNF in adipocytes (at protein level). Belongs to the GKAP1 family. protein binding Golgi apparatus signal transduction G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger identical protein binding positive regulation of insulin receptor signaling pathway uc007qtn.1 uc007qtn.2 uc007qtn.3 
ENSMUST00000091628.11 Atxn1 ENSMUST00000091628.11 ataxin 1, transcript variant 2 (from RefSeq NM_009124.6) ATX1_MOUSE ENSMUST00000091628.1 ENSMUST00000091628.10 ENSMUST00000091628.2 ENSMUST00000091628.3 ENSMUST00000091628.4 ENSMUST00000091628.5 ENSMUST00000091628.6 ENSMUST00000091628.7 ENSMUST00000091628.8 ENSMUST00000091628.9 NM_009124 P54254 Q8C866 Sca1 uc011yyv.1 uc011yyv.2 uc011yyv.3 uc011yyv.4 uc011yyv.5 Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ- mediated repression (By similarity). May be involved in RNA metabolism (By similarity). In concert with CIC and ATXN1L, involved in brain development (PubMed:28288114). Homooligomer (By similarity). Interacts with PQBP1, UBQLN4 and USP7 (By similarity). Interacts with ANP32A (PubMed:9353121). Interacts with CIC (PubMed:17190598). Directly interacts with RBPJ; this interaction is disrupted in the presence of Notch intracellular domain. Interacts with ATXN1L; competes with ATXN1L for RBPJ-binding (PubMed:17322884). Found in a complex with CIC and ATXN1L (PubMed:28288114). P54254; Q924A2: Cic; NbExp=2; IntAct=EBI-1169713, EBI-8412165; P54254; Q8CHK4: Kat5; NbExp=2; IntAct=EBI-1169713, EBI-1169948; P54254; P51448: Rora; NbExp=3; IntAct=EBI-1169713, EBI-1169722; Cytoplasm Nucleus Note=Colocalizes with USP7 in the nucleus. Expressed in the cortex and hypothalamus (at protein level). Widely expressed. In brain, the pattern of distribution is limited to neuron populations. Transient expression burst in Purkinje cells as the cerebellar cortex becomes functional (postnatal day 14), and in mesenchymal cells of the developing intervertebral disks of the spinal column. Atxn1 protein levels are directly regulated by Pum1 protein: Pum1 acts by binding to the 3'-UTR of Atxn1 mRNA, affecting Atxn1 mRNA stability and leading to reduced Atxn1 protein levels. The AXH domain is required for interaction with CIC. Ubiquitinated by UBE3A, leading to its degradation by the proteasome. The presence of poly-Gln repeats in trangenic models developed to replicate phenotypes of the spinocerebellar ataxia 1 disease (SCA1) impair ubiquitination and degradation, leading to accumulation of Atxn1 in neurons and subsequent toxicity. Sumoylation is dependent on nuclear localization and phosphorylation at Ser-751. The murine poly-Gln region is very limited in comparison to human ATXN1 and is not polymorphic. Mice with conditional knockouts of either ATXN1- ATXN1L or CIC in the developing forebrain exhibit intellectual disability, hyperactivity, social-behavioral deficits and reduced thickness of upper cortical layers. Different transgenic mouse, containing a poly-Gln region insertion in position 199 have been developed to replicate phenotypes of the spinocerebellar ataxia 1 disease (SCA1) in human (PubMed:10624951, PubMed:12086639). Heterozygous mice with a poly-Gln of 92 residues [92Q] develop the ataxia typical of human SCA1. However, they show only the phenotype associated with dysfunctional Purkinje cells and usually live a normal lifespan (PubMed:10624951). Heterozygous mice with a poly-Gln of 154 residues [154Q] develop a progressive neurological disorder that resembles human SCA1, with motor incoordination, cognitive deficits, wasting, and premature death, accompanied by Purkinje cell loss and age-related hippocampal synaptic dysfunction (PubMed:12086639). Phenotypes are caused by an accumulation of Atxn1 in neurons, exerting toxicity. The expanded poly-Gln tract causes stabilization of Atxn1 and impairs its ubiquitination and subsequent degradation, increasing its abundance in neurons (PubMed:10624951). Belongs to the ATXN1 family. negative regulation of transcription from RNA polymerase II promoter DNA binding chromatin binding RNA binding protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol regulation of transcription, DNA-templated nervous system development brain development learning memory protein C-terminus binding poly(U) RNA binding adult locomotory behavior visual learning nuclear matrix macromolecular complex poly(G) binding social behavior negative regulation of phosphorylation nuclear inclusion body identical protein binding negative regulation of insulin-like growth factor receptor signaling pathway protein self-association negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lung alveolus development anatomical structure development nuclear export excitatory postsynaptic potential positive regulation of glial cell proliferation postsynapse uc011yyv.1 uc011yyv.2 uc011yyv.3 uc011yyv.4 uc011yyv.5 
ENSMUST00000091636.5 Lrrtm2 ENSMUST00000091636.5 leucine rich repeat transmembrane neuronal 2 (from RefSeq NM_178005.4) ENSMUST00000091636.1 ENSMUST00000091636.2 ENSMUST00000091636.3 ENSMUST00000091636.4 Kiaa0416 LRRT2_MOUSE NM_178005 Q80U08 Q8BGA3 uc008ema.1 uc008ema.2 uc008ema.3 uc008ema.4 uc008ema.5 uc008ema.6 Involved in the development and maintenance of excitatory synapses in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity). Interacts with DLG4. Interacts with neurexin NRXN1; interaction is mediated by heparan sulfate glycan modification on neurexin. Cell membrane; Single-pass type I membrane protein. Postsynaptic cell membrane ; Single-pass type I membrane protein Note=Localized to excitatory synapses. Expressed in neuronal tissues. Synaptogenic effects are mediated by the extracellular LRR region. Belongs to the LRRTM family. Sequence=BAC65560.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of receptor internalization plasma membrane membrane integral component of membrane cell junction neurexin family protein binding synapse postsynaptic membrane synapse organization positive regulation of synapse assembly excitatory synapse long-term synaptic potentiation glutamatergic synapse GABA-ergic synapse integral component of postsynaptic specialization membrane integral component of postsynaptic density membrane uc008ema.1 uc008ema.2 uc008ema.3 uc008ema.4 uc008ema.5 uc008ema.6 
ENSMUST00000091641.13 Snrnp48 ENSMUST00000091641.13 small nuclear ribonucleoprotein 48 (U11/U12) (from RefSeq NM_026382.2) ENSMUST00000091641.1 ENSMUST00000091641.10 ENSMUST00000091641.11 ENSMUST00000091641.12 ENSMUST00000091641.2 ENSMUST00000091641.3 ENSMUST00000091641.4 ENSMUST00000091641.5 ENSMUST00000091641.6 ENSMUST00000091641.7 ENSMUST00000091641.8 ENSMUST00000091641.9 NM_026382 Q8BIU0 Q8BJ30 Q8CFF6 Q8VDQ5 Q9CSG3 Q9CVM5 Q9D361 SNR48_MOUSE uc007qdo.1 uc007qdo.2 uc007qdo.3 Likely involved in U12-type 5' splice site recognition. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Not found in the major spliceosome (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D361-1; Sequence=Displayed; Name=2; IsoId=Q9D361-2; Sequence=VSP_014644; Name=3; IsoId=Q9D361-3; Sequence=VSP_014642, VSP_014643; The CHHC region interacts with the 5' splice site of the U12- type Intron. Sequence=AAH37073.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; molecular_function nucleus nucleoplasm spliceosomal complex U12-type spliceosomal complex cytosol mRNA processing biological_process RNA splicing metal ion binding uc007qdo.1 uc007qdo.2 uc007qdo.3 
ENSMUST00000091648.4 Gpr31b ENSMUST00000091648.4 G protein-coupled receptor 31, D17Leh66b region (from RefSeq NM_001013832.2) ENSMUST00000091648.1 ENSMUST00000091648.2 ENSMUST00000091648.3 F8VQN3 GPR31_MOUSE Gpr31 Gpr31c NM_001013832 Q9JLS1 uc008alx.1 uc008alx.2 uc008alx.3 High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers (By similarity) (PubMed:29227475). 12-S-HETE is a eicosanoid, a 12-lipoxygenase (ALOX12) metabolite of arachidonic acid, involved in many physiologic and pathologic processes, such as cell growth, adhesion, inflammation and cancer promotion. 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways and leads to cell growth. Plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM (By similarity). Contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1(+) phagocytes for the uptake of luminal antigens (PubMed:30675063). Acts also as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury (PubMed:29227475). Proton-sensing G protein-coupled receptor. Interacts with KRAS; in a farnesylation-dependent manner. Cell membrane ; Multi-pass membrane protein Deficient mice exhibit a reduced response to enteric bacteria, showing defective dendrite protrusions of CX3CR1(+) cells in the small intestine (PubMed:30675063). Under ischemia/reperfusion injury, liver dysfunction, cell death and inflammatory induction are consistently and significantly inhibited at 6 hours after reperfusion in GPR31-deficient mice (PubMed:29227475). Belongs to the G-protein coupled receptor 1 family. response to molecule of bacterial origin G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane positive regulation of immune response uc008alx.1 uc008alx.2 uc008alx.3 
ENSMUST00000091676.12 Pramel4 ENSMUST00000091676.12 PRAME like 4, transcript variant 2 (from RefSeq NM_001358482.1) A2ASJ3 E0CXV0 ENSMUST00000091676.1 ENSMUST00000091676.10 ENSMUST00000091676.11 ENSMUST00000091676.2 ENSMUST00000091676.3 ENSMUST00000091676.4 ENSMUST00000091676.5 ENSMUST00000091676.6 ENSMUST00000091676.7 ENSMUST00000091676.8 ENSMUST00000091676.9 F6SEH0 Gm13102 NM_001358482 OTTMUSG00000010432 Pramel4 Q3ULC4 Q3ULC4_MOUSE uc008vqs.1 uc008vqs.2 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vqs.1 uc008vqs.2 
ENSMUST00000091678.3 Prl2b1 ENSMUST00000091678.3 Secreted (from UniProt Q5SXK2) AK009863 ENSMUST00000091678.1 ENSMUST00000091678.2 Prl2b1 Q5SXK2 Q5SXK2_MOUSE uc288lqt.1 uc288lqt.2 Secreted Belongs to the somatotropin/prolactin family. hormone activity extracellular region signal transduction uc288lqt.1 uc288lqt.2 
ENSMUST00000091680.9 Prl6a1 ENSMUST00000091680.9 prolactin family 6, subfamily a, member 1, transcript variant 1 (from RefSeq NM_011166.2) ENSMUST00000091680.1 ENSMUST00000091680.2 ENSMUST00000091680.3 ENSMUST00000091680.4 ENSMUST00000091680.5 ENSMUST00000091680.6 ENSMUST00000091680.7 ENSMUST00000091680.8 NM_011166 O35257 PR6A1_MOUSE Prlpb uc007pxk.1 uc007pxk.2 uc007pxk.3 Secreted Expressed in both placenta and decidual tissues. Detected first in deciduals cells early in gestation and in trophoblasts later in pregnancy. Increased gradually from days 8-12 and decrease to low levels by days 16. Belongs to the somatotropin/prolactin family. prolactin receptor binding hormone activity extracellular region extracellular space signal transduction female pregnancy positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007pxk.1 uc007pxk.2 uc007pxk.3 
ENSMUST00000091692.4 Tdpoz7 ENSMUST00000091692.4 Td and POZ domain containing 7 (from RefSeq NM_001163731.1) E0CYU8 E0CYU8_MOUSE E9QLP9 ENSMUST00000091692.1 ENSMUST00000091692.2 ENSMUST00000091692.3 NM_001163731 Tdpoz5 Tdpoz7 uc012ctk.1 uc012ctk.2 Belongs to the Tdpoz family. molecular_function cellular_component biological_process uc012ctk.1 uc012ctk.2 
ENSMUST00000091694.10 Ripor2 ENSMUST00000091694.10 RHO family interacting cell polarization regulator 2, transcript variant 3 (from RefSeq NM_178658.5) A6PW01 A6PW03 ENSMUST00000091694.1 ENSMUST00000091694.2 ENSMUST00000091694.3 ENSMUST00000091694.4 ENSMUST00000091694.5 ENSMUST00000091694.6 ENSMUST00000091694.7 ENSMUST00000091694.8 ENSMUST00000091694.9 Fam65b Kiaa0386 NM_178658 Q3TQ58 Q5SY29 Q5SZV4 Q5T0J1 Q80U16 Q8BIM7 Q8BJ19 Q8BJ22 Q8BJ32 Q8BJ54 RIPR2_MOUSE Ripor2 uc007pwb.1 uc007pwb.2 uc007pwb.3 uc007pwb.4 Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:25588844, PubMed:27269051). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (PubMed:25588844). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (PubMed:27269051). Plays a role for maintaining the structural organization of the basal domain of stereocilia (PubMed:27269051). Involved in mechanosensory hair cell function (PubMed:27269051). Required for normal hearing (PubMed:27269051). Homooligomer; homooligomerization is regulated by RHOC and leads to the formation of concatemers through the association of N- and C-termini (PubMed:27269051, PubMed:32631815). Interacts (phosphorylated form) with 14-3-3 proteins; these interactions occur during myogenic cell differentiation and also induces T cell proliferation arrest (By similarity). Interacts (phosphorylated form) with HDAC6; this interaction occurs during early myogenic differentiation, prevents HDAC6 to deacetylate tubulin and also induces T cell proliferation arrest (By similarity). Interacts with DYSF; this interaction occurs during early myogenic differentiation (PubMed:24687993). Interacts with MYOF (By similarity). Interacts (via active GTP- or inactive GDP-bound forms) with RHOA; this interaction is direct, blocks the loading of GTP to RHOA and decreases upon chemokine CCL19 stimulation in primary T lymphocytes (PubMed:27269051). Interacts with RHOC (PubMed:27269051, PubMed:32631815). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2- mediated RHOA activity (By similarity). Interacts with YWHAE (By similarity). Interacts with YWHAQ (By similarity). Cytoplasm Cytoplasm, cytoskeleton Cell projection, filopodium Cell projection, stereocilium ll projection, stereocilium membrane Apical cell membrane Note=Localized in the cytoplasm in cells undergoing mitosis (By similarity). Colocalized with F-actin (By similarity). Accumulates at the leading edge of polarized neutrophils in a chemokine-dependent manner (By similarity). Localized with RHOC within the basal domain of hair cell stereocilia, near the taper region (PubMed:27269051). Detected in punctate pattern forming a circumferential ring at the stereocilia base (PubMed:27269051). Localized to the apical stereocilia of inner and outer hair cells (By similarity). Not detected as a membrane-associated protein in stereocilia (PubMed:27269051). Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q80U16-1; Sequence=Displayed; Name=2; IsoId=Q80U16-2; Sequence=VSP_025914, VSP_025917; Name=3; IsoId=Q80U16-3; Sequence=VSP_025910, VSP_025913; Name=4; IsoId=Q80U16-4; Sequence=VSP_025911, VSP_025912; Name=5; IsoId=Q80U16-5; Sequence=VSP_025908, VSP_025909, VSP_025914, VSP_025917; Name=6; IsoId=Q80U16-6; Sequence=VSP_025908, VSP_025909, VSP_025915, VSP_025916; Name=7; IsoId=Q80U16-7; Sequence=VSP_025907, VSP_025909, VSP_025914, VSP_025917; Expressed in the cochlea (PubMed:24958875, PubMed:32631815). Expressed in inner hair cells and outer hair cells and Hensen's cells (at protein level) (PubMed:27269051, PubMed:32631815). Expressed in the brain, cerebellum, spinal cord, retina, heart, spleen liver, kidney, bladder, muscle and lung (PubMed:24958875, PubMed:27269051). Expressed in the cochlea of the inner ear (PubMed:24958875, PubMed:27269051). Up-regulated during regenerating muscle tissue. Phosphorylated. Chemokine-induced phosphorylation in neutrophils occurs in a PKC- and AKT-dependent manner, resulting in RIPOR2 interaction with YWHAB and stabilization. Phosphorylated by PKCA, AKT1 and MAPKAPK1A; in vitro. Mice are deaf at 4 weeks of age (PubMed:27269051). Show abnormal hair bundle morphology and polarity and stereociliary growth in the cochlea of the inner ear (PubMed:27269051). Display mislocalization of protein TPRN to the base of stereocilia (PubMed:27269051). Show reduced mechanotransduction currents in hair bundles of outer hair cells (PubMed:27269051). Mice show impaired neutrophil chemotaxis, increased neutrophil adhesion to endothelial cell and reduced neutrophil infiltration into inflamed peritonea (PubMed:25588844). Display increased chemokine-induced RHOA activity and mislocalization of myosin light chain MYL2 in neutrophils (PubMed:25588844). Belongs to the RIPOR family. Sequence=BAC65551.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding cytoplasm cytoskeleton plasma membrane chemotaxis cell adhesion negative regulation of cell adhesion muscle organ development sensory perception of sound negative regulation of signal transduction membrane apical plasma membrane cell differentiation filopodium stereocilium negative regulation of Rho protein signal transduction negative regulation of T cell proliferation identical protein binding cell projection establishment of protein localization positive regulation of myoblast differentiation skeletal muscle fiber development protein homooligomerization positive regulation of filopodium assembly auditory receptor cell stereocilium organization stereocilium membrane positive regulation of cell cycle arrest cellular response to mechanical stimulus 14-3-3 protein binding positive regulation of neutrophil chemotaxis regulation of mitotic spindle assembly positive regulation of myoblast fusion negative regulation of establishment of T cell polarity cellular response to chemokine regulation of establishment of cell polarity positive regulation of neutrophil extravasation negative regulation of T cell migration negative regulation of Rho guanyl-nucleotide exchange factor activity uc007pwb.1 uc007pwb.2 uc007pwb.3 uc007pwb.4 
ENSMUST00000091701.3 H3c1 ENSMUST00000091701.3 H3 clustered histone 1 (from RefSeq NM_013550.5) ENSMUST00000091701.1 ENSMUST00000091701.2 H3.1-221 H3.1-291 H3.1-I H31_MOUSE H3a H3c1 H3c10 H3c11 H3c8 H3g H3h H3i Hist1h3a Hist1h3g Hist1h3h Hist1h3i NM_013550 P02295 P02296 P16106 P68433 Q05A97 Q3B7Z8 Q3B7Z9 Q5T009 uc007puy.1 uc007puy.2 uc007puy.3 uc007puy.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK018952.1, BC115816.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with TONSL; CHAF1A; CHAF1B; MCM2 and DNAJC9 (By similarity). P68433; P83917: Cbx1; NbExp=6; IntAct=EBI-79743, EBI-78119; P68433; Q8WTS6: SETD7; Xeno; NbExp=2; IntAct=EBI-79743, EBI-1268586; Nucleus. Chromosome. Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity). Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys- 10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. This histone is only present in mammals. Belongs to the histone H3 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly macromolecular complex protein heterodimerization activity protein heterotetramerization regulation of gene silencing uc007puy.1 uc007puy.2 uc007puy.3 uc007puy.4 
ENSMUST00000091703.3 H3c2 ENSMUST00000091703.3 H3 clustered histone 2 (from RefSeq NM_178203.3) A3KMN6 ENSMUST00000091703.1 ENSMUST00000091703.2 H3-143 H3-53 H3-B H3-F H3.2 H3.2-221 H3.2-614 H3.2-615 H3.2-616 H32_MOUSE H3b H3c13 H3c14 H3c15 H3c2 H3c3 H3c4 H3c6 H3c7 H3f Hist1h3b Hist1h3c Hist1h3d Hist1h3e Hist1h3f Hist2h3b Hist2h3c1 Hist2h3c2 Hist2h3ca1 Hist2h3ca2 NM_178203 P02295 P02297 P16105 P17269 P17320 P84228 Q60582 Q78E59 Q8CGN9 uc007puu.1 uc007puu.2 uc007puu.3 uc007puu.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: W88216.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer (By similarity). Interacts with DNAJC9, CHAF1A and CHAF1B (By similarity). P84228; Q8TF76-1: HASPIN; Xeno; NbExp=3; IntAct=EBI-2658213, EBI-15815652; Nucleus. Chromosome. Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity). Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys- 10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H3 family. Sequence=AAH94041.1; Type=Erroneous initiation; Evidence=; Sequence=AAO06264.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter nuclear chromosome chromatin nucleosome nuclear nucleosome DNA binding chromatin binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly macromolecular complex protein heterodimerization activity protein heterotetramerization regulation of gene silencing uc007puu.1 uc007puu.2 uc007puu.3 uc007puu.4 
ENSMUST00000091706.14 Hfe ENSMUST00000091706.14 homeostatic iron regulator, transcript variant 1 (from RefSeq NM_010424.5) ENSMUST00000091706.1 ENSMUST00000091706.10 ENSMUST00000091706.11 ENSMUST00000091706.12 ENSMUST00000091706.13 ENSMUST00000091706.2 ENSMUST00000091706.3 ENSMUST00000091706.4 ENSMUST00000091706.5 ENSMUST00000091706.6 ENSMUST00000091706.7 ENSMUST00000091706.8 ENSMUST00000091706.9 HFE_MOUSE Mr2 NM_010424 P70387 Q14AQ5 Q5SZ90 Q9D754 uc007pup.1 uc007pup.2 uc007pup.3 Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. Binds TFR through the extracellular domain in a pH-dependent manner. Cell membrane ; Single-pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent negative regulation of T cell antigen processing and presentation negative regulation of T cell cytokine production receptor binding extracellular space early endosome plasma membrane ion transport cellular iron ion homeostasis acute-phase response female pregnancy external side of plasma membrane response to iron ion cellular response to iron ion starvation positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation membrane integral component of membrane BMP signaling pathway beta-2-microglobulin binding cytoplasmic vesicle positive regulation of protein binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of iron ion transport co-receptor binding hormone biosynthetic process apical part of cell basal part of cell positive regulation of receptor-mediated endocytosis perinuclear region of cytoplasm recycling endosome iron ion homeostasis multicellular organismal iron ion homeostasis cellular response to iron ion positive regulation of peptide hormone secretion liver regeneration iron ion import across plasma membrane negative regulation of receptor binding positive regulation of receptor binding negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I positive regulation of ferrous iron binding positive regulation of transferrin receptor binding terminal web transferrin receptor binding response to iron ion starvation HFE-transferrin receptor complex regulation of protein localization to cell surface negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of receptor activity positive regulation of receptor activity negative regulation of CD8-positive, alpha-beta T cell activation uc007pup.1 uc007pup.2 uc007pup.3 
ENSMUST00000091709.3 H2bc15 ENSMUST00000091709.3 H2B clustered histone 15 (from RefSeq NM_178201.3) ENSMUST00000091709.1 ENSMUST00000091709.2 H2B1F_MOUSE H2b-f H2b-j H2b-l H2b-n H2bc11 H2bc13 H2bc15 H2bc7 Hist1h2bf Hist1h2bj Hist1h2bl Hist1h2bn NM_178201 P10853 Q5SZZ3 uc007prh.1 uc007prh.2 uc007prh.3 uc007prh.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome innate immune response in mucosa DNA binding extracellular space nucleus nucleoplasm chromosome cytosol nucleosome assembly antibacterial humoral response identical protein binding protein heterodimerization activity defense response to Gram-positive bacterium uc007prh.1 uc007prh.2 uc007prh.3 uc007prh.4 
ENSMUST00000091737.2 Vmn1r194 ENSMUST00000091737.2 vomeronasal 1 receptor 194 (from RefSeq NM_001080972.1) ENSMUST00000091737.1 J3JS27 J3JS27_MOUSE NM_001080972 Vmn1r194 Vmn1r198 uc007psk.1 uc007psk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc007psk.1 uc007psk.2 
ENSMUST00000091741.6 H2ac11 ENSMUST00000091741.6 H2A clustered histone 11 (from RefSeq NM_178186.3) C0HKE9 ENSMUST00000091741.1 ENSMUST00000091741.2 ENSMUST00000091741.3 ENSMUST00000091741.4 ENSMUST00000091741.5 H2A1P_MOUSE Hist1h2ap NM_178186 P10812 P22752 Q149U0 Q5SZZ2 uc007psd.1 uc007psd.2 uc007psd.3 uc007psd.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC065803.1, BY710794.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007psd.1 uc007psd.2 uc007psd.3 uc007psd.4 
ENSMUST00000091742.6 H2ac12 ENSMUST00000091742.6 H2A clustered histone 12 (from RefSeq NM_175659.2) ENSMUST00000091742.1 ENSMUST00000091742.2 ENSMUST00000091742.3 ENSMUST00000091742.4 ENSMUST00000091742.5 H2A1H_MOUSE H2ac12 Hist1h2ah NM_175659 Q8CGP6 uc007psa.1 uc007psa.2 uc007psa.3 uc007psa.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. ##Evidence-Data-START## Transcript is intronless :: BC139479.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Chromosome Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007psa.1 uc007psa.2 uc007psa.3 uc007psa.4 
ENSMUST00000091745.6 H2ac23 ENSMUST00000091745.6 H2A clustered histone 23 (from RefSeq NM_001177544.2) C0HKE9 ENSMUST00000091745.1 ENSMUST00000091745.2 ENSMUST00000091745.3 ENSMUST00000091745.4 ENSMUST00000091745.5 H2A1P_MOUSE Hist1h2ap NM_001177544 P10812 P22752 Q149U0 Q5SZZ2 uc007prq.1 uc007prq.2 uc007prq.3 uc007prq.4 uc007prq.5 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007prq.1 uc007prq.2 uc007prq.3 uc007prq.4 uc007prq.5 
ENSMUST00000091749.4 H2bc23 ENSMUST00000091749.4 H2B clustered histone 23, transcript variant 1 (from RefSeq NM_001097979.2) ENSMUST00000091749.1 ENSMUST00000091749.2 ENSMUST00000091749.3 H2bc23 H2bc24 NM_001097979 Q8CBB6 Q8CBB6_MOUSE uc011ywu.1 uc011ywu.2 uc011ywu.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Sep 2015]. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2B family. nucleosome DNA binding nucleus nucleoplasm chromosome cytosol biological_process enzyme binding macromolecular complex ubiquitin-like protein ligase binding protein heterodimerization activity STAT family protein binding uc011ywu.1 uc011ywu.2 uc011ywu.3 
ENSMUST00000091751.3 H2ac22 ENSMUST00000091751.3 H2A clustered histone 22 (from RefSeq NM_178184.3) C0HKE9 ENSMUST00000091751.1 ENSMUST00000091751.2 H2A1P_MOUSE Hist1h2ap NM_178184 P10812 P22752 Q149U0 Q5SZZ2 uc007prk.1 uc007prk.2 uc007prk.3 uc007prk.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: SRR7345562.995386.1, SRR7345562.2873308.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007prk.1 uc007prk.2 uc007prk.3 uc007prk.4 
ENSMUST00000091752.5 H3c3 ENSMUST00000091752.5 H3 clustered histone 3 (from RefSeq NM_175653.2) A3KMN6 ENSMUST00000091752.1 ENSMUST00000091752.2 ENSMUST00000091752.3 ENSMUST00000091752.4 H3-143 H3-53 H3-B H3-F H3.2 H3.2-221 H3.2-614 H3.2-615 H3.2-616 H32_MOUSE H3b H3c13 H3c14 H3c15 H3c2 H3c3 H3c4 H3c6 H3c7 H3f Hist1h3b Hist1h3c Hist1h3d Hist1h3e Hist1h3f Hist2h3b Hist2h3c1 Hist2h3c2 Hist2h3ca1 Hist2h3ca2 NM_175653 P02295 P02297 P16105 P17269 P17320 P84228 Q60582 Q78E59 Q8CGN9 uc007pur.1 uc007pur.2 uc007pur.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer (By similarity). Interacts with DNAJC9, CHAF1A and CHAF1B (By similarity). P84228; Q8TF76-1: HASPIN; Xeno; NbExp=3; IntAct=EBI-2658213, EBI-15815652; Nucleus. Chromosome. Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity). Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys- 10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H3 family. Sequence=AAH94041.1; Type=Erroneous initiation; Evidence=; Sequence=AAO06264.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter nuclear chromosome chromatin nucleosome nuclear nucleosome DNA binding chromatin binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly macromolecular complex protein heterodimerization activity protein heterotetramerization regulation of gene silencing uc007pur.1 uc007pur.2 uc007pur.3 
ENSMUST00000091756.2 H2bc13 ENSMUST00000091756.2 H2B clustered histone 13 (from RefSeq NM_178199.3) ENSMUST00000091756.1 H2B1F_MOUSE H2b-f H2b-j H2b-l H2b-n H2bc11 H2bc13 H2bc15 H2bc7 Hist1h2bf Hist1h2bj Hist1h2bl Hist1h2bn NM_178199 P10853 Q5SZZ3 uc007pra.1 uc007pra.2 uc007pra.3 uc007pra.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: SRR7345560.725115.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome innate immune response in mucosa DNA binding extracellular space nucleus nucleoplasm chromosome cytosol nucleosome assembly antibacterial humoral response identical protein binding protein heterodimerization activity defense response to Gram-positive bacterium uc007pra.1 uc007pra.2 uc007pra.3 uc007pra.4 
ENSMUST00000091763.3 Nme8 ENSMUST00000091763.3 NME/NM23 family member 8, transcript variant 1 (from RefSeq NM_181591.3) ENSMUST00000091763.1 ENSMUST00000091763.2 NM_181591 Q715T0 Q80W74 Sptrx2 TXND3_MOUSE Txndc3 uc007ppj.1 uc007ppj.2 uc007ppj.3 uc007ppj.4 Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds (By similarity). Monomer. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q715T0-1; Sequence=Displayed; Name=2; IsoId=Q715T0-2; Sequence=VSP_014330, VSP_014331; Testis-specific. Expressed mainly in round spermatids. First expressed after puberty. Contains 3 inactive NDK domains that each lack the active His residue, suggesting that they have no NDP kinase activity. In the C-terminal section; belongs to the NDK family. cytoplasm multicellular organism development spermatogenesis microtubule binding cell differentiation flagellated sperm motility cellular response to reactive oxygen species sperm fibrous sheath outer dynein arm cell redox homeostasis cilium assembly sperm principal piece sperm cytoplasmic droplet uc007ppj.1 uc007ppj.2 uc007ppj.3 uc007ppj.4 
ENSMUST00000091776.7 Bhmt1b ENSMUST00000091776.7 Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. (from UniProt O35490) AF033381 BHMT1_MOUSE Bhmt ENSMUST00000091776.1 ENSMUST00000091776.2 ENSMUST00000091776.3 ENSMUST00000091776.4 ENSMUST00000091776.5 ENSMUST00000091776.6 O35490 Q3UEM1 Q3UL72 Q561N0 uc289pwg.1 uc289pwg.2 uc289pwg.3 Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. Reaction=glycine betaine + L-homocysteine = L-methionine + N,N- dimethylglycine; Xref=Rhea:RHEA:22336, ChEBI:CHEBI:17750, ChEBI:CHEBI:57844, ChEBI:CHEBI:58199, ChEBI:CHEBI:58251; EC=2.1.1.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22337; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. Homotetramer. Cytoplasm, cytosol Nucleus Note=Predominantly localized in the cytoplasm with a small fraction detected in the nucleus. Translocates into the nucleus upon oxidative stress. cytoplasm cytosol protein methylation amino-acid betaine metabolic process amino-acid betaine catabolic process methyltransferase activity zinc ion binding methionine biosynthetic process transferase activity methylation macromolecular complex macromolecular complex binding metal ion binding betaine-homocysteine S-methyltransferase activity extracellular exosome L-methionine salvage uc289pwg.1 uc289pwg.2 uc289pwg.3 
ENSMUST00000091791.6 A630073D07Rik ENSMUST00000091791.6 RIKEN cDNA A630073D07 gene (from RefSeq NM_001142969.1) A630073D07Rik E9PWS6 E9PWS6_MOUSE ENSMUST00000091791.1 ENSMUST00000091791.2 ENSMUST00000091791.3 ENSMUST00000091791.4 ENSMUST00000091791.5 NM_001142969 uc012euf.1 uc012euf.2 molecular_function cellular_component biological_process uc012euf.1 uc012euf.2 
ENSMUST00000091831.13 Smad2 ENSMUST00000091831.13 SMAD family member 2, transcript variant 3 (from RefSeq NM_001311070.1) ENSMUST00000091831.1 ENSMUST00000091831.10 ENSMUST00000091831.11 ENSMUST00000091831.12 ENSMUST00000091831.2 ENSMUST00000091831.3 ENSMUST00000091831.4 ENSMUST00000091831.5 ENSMUST00000091831.6 ENSMUST00000091831.7 ENSMUST00000091831.8 ENSMUST00000091831.9 Madh2 Madr2 NM_001311070 Q62432 Q6GU18 Q6VP00 Q9D8P6 SMAD2_MOUSE uc289pqy.1 uc289pqy.2 Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (PubMed:33548622). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). Monomer; in the absence of TGF-beta (By similarity). Heterodimer; in the presence of TGF-beta (By similarity). Forms a heterodimer with co-SMAD, SMAD4, in the nucleus to form the transactivation complex SMAD2/SMAD4 (PubMed:21145499). Found in a complex with SMAD3 and TRIM33 upon addition of TGF-beta (By similarity). Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4 (By similarity). Interacts (via the MH2 domain) with ZFYVE9; may form trimers with the SMAD4 co-SMAD (PubMed:15356634). Interacts with TAZ/WWRT1 (By similarity). Interacts with FOXH1 (By similarity). Interacts with SNW1 (By similarity). Interacts with CREB- binding protein (CBP) and EP300 (By similarity). Interacts with SNON (By similarity). Interacts with ALK4/ACVR1B (By similarity). Interacts with SKOR1 (By similarity). Interacts with SKOR2 (By similarity). Interacts with PRDM16 (By similarity). Interacts (via MH2 domain) with LEMD3 (By similarity). Interacts with RBPMS (By similarity). Interacts with WWP1. Interacts (dephosphorylated form, via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination of the TGF-beta signaling (By similarity). Interacts with PDPK1 (via PH domain) (By similarity). Interacts with DAB2; the interactions are enhanced upon TGF-beta stimulation (By similarity). Interacts with USP15 (By similarity). Interacts with PPP5C (PubMed:22781750). Interacts with LDLRAD4 (via the SMAD interaction motif) (By similarity). Interacts (via MH2 domain) with PMEPA1 (via the SMAD interaction motif) (By similarity). Interacts with ZFHX3 (By similarity). Interacts with ZNF451 (By similarity). Interacts with SMURF2 when phosphorylated on Ser-465/467 (By similarity). Interacts with PPM1A (By similarity). Interacts with TGF-beta (By similarity). Interacts with TGFBR1 (By similarity). Interacts with TGIF (By similarity). Interacts with SMAD3 and TRIM33 (By similarity). Interacts with ZNF580 (By similarity). Interacts with NEDD4L in response to TGF- beta (PubMed:15496141). Interacts with HGS (PubMed:11094085). Interacts with AIP1 (PubMed:10681527). Interacts with WWP1 (PubMed:15221015). Interacts with PML (PubMed:15356634). Interacts weakly with ZNF8 (PubMed:12370310). Interacts (when phosphorylated) with RNF111; RNF111 acts as an enhancer of the transcriptional responses by mediating ubiquitination and degradation of SMAD2 inhibitors (PubMed:17341133). Interacts with YAP1 (when phosphorylated at 'Ser-112') (PubMed:21145499). Interacts when phosphorylated with IPO7; the interaction facilitates translocation of SMAD2 to the nucleus (PubMed:33548622). Cytoplasm cleus te=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 (PubMed:21145499, PubMed:33548622). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (By similarity). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (PubMed:21145499). Event=Alternative splicing; Named isoforms=2; Comment=mRNA corresponding to the isoform Long is approximately 20-fold more abundant. Both forms are coexpressed throughout mouse development.; Name=Long; IsoId=Q62432-1; Sequence=Displayed; Name=Short; Synonyms=Deltaexon3; IsoId=Q62432-2; Sequence=VSP_021571; In response to TGF-beta, phosphorylated on the C-terminal SXS motif by TGF-beta and activin type 1 receptor kinases, phosphorylation declines progressively in a KMT5A-dependent manner. Phosphorylation in this motif is required for interaction with a number of proteins including SMURF2, SNON and SMAD4 in response to TGF-beta. Dephosphorylated in this motif by PPM1A leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of the TGF-beta signaling. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1. In response to TGF-beta, ubiquitinated by NEDD4L; which promotes its degradation. Monoubiquitinated, leading to prevent DNA-binding (PubMed:15496141). Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (By similarity). Ubiquitinated by RNF111, leading to its degradation: only SMAD2 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD2 and regulating its turnover (PubMed:17341133). Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity. Belongs to the dwarfin/SMAD family. nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ureteric bud development in utero embryonic development endoderm formation mesoderm formation DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transforming growth factor beta receptor binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm regulation of transcription, DNA-templated protein phosphorylation transforming growth factor beta receptor signaling pathway common-partner SMAD protein phosphorylation SMAD protein complex assembly zygotic specification of dorsal/ventral axis gastrulation pattern specification process endoderm development heart development transcription factor binding negative regulation of cell proliferation response to glucose post-embryonic development embryonic pattern specification anterior/posterior pattern specification positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition regulation of transforming growth factor beta receptor signaling pathway phosphatase binding signal transduction involved in regulation of gene expression insulin secretion lung development adrenal gland development positive regulation of BMP signaling pathway transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity pancreas development ubiquitin protein ligase binding activin responsive factor complex activin receptor signaling pathway macromolecular complex activating transcription factor binding type I transforming growth factor beta receptor binding organ growth intracellular signal transduction nodal signaling pathway wound healing protein homodimerization activity cell fate commitment negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter SMAD binding metal ion binding tau protein binding paraxial mesoderm morphogenesis developmental growth embryonic foregut morphogenesis embryonic cranial skeleton morphogenesis regulation of binding pericardium development SMAD protein signal transduction co-SMAD binding I-SMAD binding R-SMAD binding response to cholesterol primary miRNA binding SMAD protein complex SMAD2-SMAD3 protein complex disordered domain specific binding positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry uc289pqy.1 uc289pqy.2 
ENSMUST00000091848.7 Akr1e1 ENSMUST00000091848.7 aldo-keto reductase family 1, member E1 (from RefSeq NM_018859.2) AKCL2_MOUSE Akr1cl2 Akr1e2 ENSMUST00000091848.1 ENSMUST00000091848.2 ENSMUST00000091848.3 ENSMUST00000091848.4 ENSMUST00000091848.5 ENSMUST00000091848.6 NM_018859 O09125 Q9DCT1 uc007pjs.1 uc007pjs.2 uc007pjs.3 Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol. Reaction=1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH; Xref=Rhea:RHEA:20665, ChEBI:CHEBI:15378, ChEBI:CHEBI:16070, ChEBI:CHEBI:16715, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.263; Evidence=; Inhibited by p-chloromercuribenzoic acid and alkyliodines. Kinetic parameters: KM=1.02 mM for 1,5-anhydro-D-fructose ; Vmax=0.57 umol/min/mg enzyme ; Monomer. Cytoplasm Belongs to the aldo/keto reductase family. alditol:NADP+ 1-oxidoreductase activity nucleoplasm cytoplasm Golgi apparatus cytosol alcohol dehydrogenase (NADP+) activity oxidoreductase activity 1,5-anhydro-D-fructose reductase activity oxidation-reduction process uc007pjs.1 uc007pjs.2 uc007pjs.3 
ENSMUST00000091851.10 Mapk4 ENSMUST00000091851.10 mitogen-activated protein kinase 4, transcript variant 1 (from RefSeq NM_172632.2) ENSMUST00000091851.1 ENSMUST00000091851.2 ENSMUST00000091851.3 ENSMUST00000091851.4 ENSMUST00000091851.5 ENSMUST00000091851.6 ENSMUST00000091851.7 ENSMUST00000091851.8 ENSMUST00000091851.9 Erk4 MK04_MOUSE NM_172632 Prkm4 Q6P5G0 uc008fpb.1 uc008fpb.2 uc008fpb.3 uc008fpb.4 Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation at Ser-186. Homodimer. Heterodimer with ERK3/MAPK6. Interacts with (via FRIEDE motif) MAPKAPK5. Cytoplasm Nucleus Note=Translocates to the cytoplasm following interaction with MAPKAPK5. The FRIEDE motif is required for docking MAPKAPK5. In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose phosphorylation activates the MAP kinases. Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. MAPK cascade nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity ATP binding nucleus cytoplasm protein phosphorylation cell cycle regulation of gene expression kinase activity phosphorylation transferase activity protein kinase binding intracellular signal transduction protein homodimerization activity protein heterodimerization activity cellular response to organic substance uc008fpb.1 uc008fpb.2 uc008fpb.3 uc008fpb.4 
ENSMUST00000091852.5 Mex3c ENSMUST00000091852.5 mex3 RNA binding family member C (from RefSeq NM_001039214.4) ENSMUST00000091852.1 ENSMUST00000091852.2 ENSMUST00000091852.3 ENSMUST00000091852.4 MEX3C_MOUSE NM_001039214 Q05A36 Q2VPQ2 Rkhd2 uc008fot.1 uc008fot.2 uc008fot.3 uc008fot.4 RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Interacts with USP7, which antagonizes the ability to degrade mRNA. Nucleus Cytoplasm Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Binds RNA through its KH domains. Phosphorylated. Sequence=AAI25428.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; chondrocyte hypertrophy nucleic acid binding RNA binding nucleus cytoplasm transferase activity regulation of fat cell differentiation metal ion binding energy homeostasis uc008fot.1 uc008fot.2 uc008fot.3 uc008fot.4 
ENSMUST00000091878.6 Zfp987 ENSMUST00000091878.6 zinc finger protein 987 (from RefSeq NM_001037926.2) ENSMUST00000091878.1 ENSMUST00000091878.2 ENSMUST00000091878.3 ENSMUST00000091878.4 ENSMUST00000091878.5 Gm13051 NM_001037926 OTTMUSG00000010173 Q32P14 Q32P14_MOUSE Zfp987 uc008vsk.1 uc008vsk.2 uc008vsk.3 uc008vsk.4 uc008vsk.5 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc008vsk.1 uc008vsk.2 uc008vsk.3 uc008vsk.4 uc008vsk.5 
ENSMUST00000091879.12 Zfp942 ENSMUST00000091879.12 zinc finger protein 942 (from RefSeq NM_001199048.1) B8JJA7 B8JJA7_MOUSE E9Q0I6 ENSMUST00000091879.1 ENSMUST00000091879.10 ENSMUST00000091879.11 ENSMUST00000091879.2 ENSMUST00000091879.3 ENSMUST00000091879.4 ENSMUST00000091879.5 ENSMUST00000091879.6 ENSMUST00000091879.7 ENSMUST00000091879.8 ENSMUST00000091879.9 NM_001199048 Zfp942 Zfp944 uc008arl.1 uc008arl.2 uc008arl.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008arl.1 uc008arl.2 uc008arl.3 
ENSMUST00000091892.4 Ctxn3 ENSMUST00000091892.4 cortexin 3 (from RefSeq NM_001134697.1) CTXN3_MOUSE ENSMUST00000091892.1 ENSMUST00000091892.2 ENSMUST00000091892.3 NM_001134697 Q8BXZ0 uc008ezd.1 uc008ezd.2 uc008ezd.3 uc008ezd.4 Membrane ; Single-pass membrane protein Belongs to the cortexin family. molecular_function cellular_component biological_process membrane integral component of membrane uc008ezd.1 uc008ezd.2 uc008ezd.3 uc008ezd.4 
ENSMUST00000091900.11 Prdm6 ENSMUST00000091900.11 PR domain containing 6 (from RefSeq NM_001033281.3) B9EIB0 ENSMUST00000091900.1 ENSMUST00000091900.10 ENSMUST00000091900.2 ENSMUST00000091900.3 ENSMUST00000091900.4 ENSMUST00000091900.5 ENSMUST00000091900.6 ENSMUST00000091900.7 ENSMUST00000091900.8 ENSMUST00000091900.9 Gm92 NM_001033281 PRDM6_MOUSE Prism Q2I2X0 Q2I2X1 Q3UX75 Q3UZD5 uc008exv.1 uc008exv.2 uc008exv.3 Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression (PubMed:16537907, PubMed:17662997). Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells (PubMed:27181681, PubMed:16537907, PubMed:17662997). Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a (PubMed:16537907). According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (PubMed:17662997). Reaction=L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60344, Rhea:RHEA-COMP:15554, Rhea:RHEA-COMP:15555, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.361; Evidence=; Interacts with HDAC1, HDAC2, HDAC3, CBX1 and EP300. Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3UZD5-1; Sequence=Displayed; Name=2; IsoId=Q3UZD5-2; Sequence=VSP_036371; Name=3; IsoId=Q3UZD5-3; Sequence=VSP_036372; Name=4; IsoId=Q3UZD5-4; Sequence=VSP_036373; Expressed in a variety of smooth muscle-containing tissues and displays especially robust expression in the cardiac outflow tract and descending aorta during embryogenesis. Also enriched in vascular precursors during development. Highly expressed in ductus arteriosus prenatally, expression declines rapildy after birth. Belongs to the class V-like SAM-binding methyltransferase superfamily. RNA polymerase II regulatory region sequence-specific DNA binding nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus chromatin organization methyltransferase activity transferase activity histone-lysine N-methyltransferase activity neurogenesis chromatin DNA binding methylation histone lysine methylation protein homodimerization activity sequence-specific DNA binding negative regulation of transcription, DNA-templated metal ion binding negative regulation of smooth muscle cell differentiation positive regulation of histone H3-K9 methylation histone methyltransferase binding uc008exv.1 uc008exv.2 uc008exv.3 
ENSMUST00000091903.5 Sh3bp5 ENSMUST00000091903.5 SH3-domain binding protein 5 (BTK-associated), transcript variant 1 (from RefSeq NM_011894.4) 3BP5_MOUSE ENSMUST00000091903.1 ENSMUST00000091903.2 ENSMUST00000091903.3 ENSMUST00000091903.4 NM_011894 Q3TTD6 Q8C903 Q8VCZ0 Q9Z131 Sab uc007sxp.1 uc007sxp.2 uc007sxp.3 uc007sxp.4 Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (By similarity). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. Interacts with BTK (By similarity). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (By similarity). Interacts with GDP-bound and nucleotide-free forms of RAB11A (PubMed:26506309). Cytoplasmic vesicle membrane ; Peripheral membrane protein Mitochondrion Note=Colocalizes with RAB11A on cytoplasmic vesicle membranes. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Z131-1; Sequence=Displayed; Name=2; IsoId=Q9Z131-2; Sequence=VSP_010882; Name=3; IsoId=Q9Z131-3; Sequence=VSP_022572, VSP_010882; The N-terminal half of the protein mediates interaction with RAB11A and functions as a guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. Belongs to the SH3BP5 family. Sequence=BAC31530.1; Type=Erroneous initiation; Evidence=; protein kinase inhibitor activity guanyl-nucleotide exchange factor activity nucleoplasm cytoplasm mitochondrion negative regulation of protein kinase activity membrane nuclear body Rab guanyl-nucleotide exchange factor activity SH3 domain binding cytoplasmic vesicle membrane cytoplasmic vesicle intracellular signal transduction negative regulation of protein tyrosine kinase activity uc007sxp.1 uc007sxp.2 uc007sxp.3 uc007sxp.4 
ENSMUST00000091920.6 Rbm27 ENSMUST00000091920.6 RNA binding motif protein 27, transcript variant 2 (from RefSeq NM_172626.3) E9QM85 ENSMUST00000091920.1 ENSMUST00000091920.2 ENSMUST00000091920.3 ENSMUST00000091920.4 ENSMUST00000091920.5 Kiaa1311 NM_172626 Q5SFM8 Q6ZPT9 Q7TQK8 Q8C2X5 Q8C9A5 RBM27_MOUSE Rbm27 uc008etr.1 uc008etr.2 uc008etr.3 uc008etr.4 May be involved in the turnover of nuclear polyadenylated (pA+) RNA. Cytoplasm Nucleus speckle Note=Incorporated into the nuclear speckles and to speckles proximal to the nuclear periphery. Also localizes to punctate structures in the cytoplasm termed cytospeckles. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5SFM8-1; Sequence=Displayed; Name=2; IsoId=Q5SFM8-2; Sequence=VSP_022462; Name=3; IsoId=Q5SFM8-3; Sequence=VSP_022463; The RRM domain mediates integration into cytospeckles. Sequence=AAH54080.1; Type=Frameshift; Evidence=; Sequence=BAC31304.2; Type=Frameshift; Evidence=; Sequence=BAC39993.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleic acid binding RNA binding mRNA binding nucleus cytoplasm mRNA processing nuclear speck positive regulation of RNA export from nucleus metal ion binding uc008etr.1 uc008etr.2 uc008etr.3 uc008etr.4 
ENSMUST00000091924.10 Polr3gl ENSMUST00000091924.10 polymerase (RNA) III (DNA directed) polypeptide G like, transcript variant 1 (from RefSeq NM_027241.4) ENSMUST00000091924.1 ENSMUST00000091924.2 ENSMUST00000091924.3 ENSMUST00000091924.4 ENSMUST00000091924.5 ENSMUST00000091924.6 ENSMUST00000091924.7 ENSMUST00000091924.8 ENSMUST00000091924.9 NM_027241 Polr3gl Q8R0C0 Q9D8G0 RPC7L_MOUSE uc008qnf.1 uc008qnf.2 uc008qnf.3 uc008qnf.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Pol III exists as two alternative complexes defined by the mutually exclusive incorporation of subunit POLR3G/RPC7alpha or POLR3GL/RPC7beta. Found in a trimeric complex with POLR3C/RPC3 and POLR3F/RPC6. Directly interacts with POLR3C (By similarity). Nucleus Expressed in the liver. Belongs to the eukaryotic RPC7 RNA polymerase subunit family. Sequence=AAH27083.1; Type=Frameshift; Evidence=; DNA-directed 5'-3' RNA polymerase activity nucleus DNA-directed RNA polymerase III complex transcription from RNA polymerase III promoter nuclear chromatin uc008qnf.1 uc008qnf.2 uc008qnf.3 uc008qnf.4 
ENSMUST00000091935.7 Pcdhga9 ENSMUST00000091935.7 protocadherin gamma subfamily A, 9 (from RefSeq NM_033592.3) ENSMUST00000091935.1 ENSMUST00000091935.2 ENSMUST00000091935.3 ENSMUST00000091935.4 ENSMUST00000091935.5 ENSMUST00000091935.6 NM_033592 Pcdhga9 Q91XX9 Q91XX9_MOUSE uc008eqx.1 uc008eqx.2 uc008eqx.3 uc008eqx.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane metal ion binding uc008eqx.1 uc008eqx.2 uc008eqx.3 uc008eqx.4 
ENSMUST00000091967.13 Bin1 ENSMUST00000091967.13 bridging integrator 1, transcript variant 2 (from RefSeq NM_001083334.1) Bin1 ENSMUST00000091967.1 ENSMUST00000091967.10 ENSMUST00000091967.11 ENSMUST00000091967.12 ENSMUST00000091967.2 ENSMUST00000091967.3 ENSMUST00000091967.4 ENSMUST00000091967.5 ENSMUST00000091967.6 ENSMUST00000091967.7 ENSMUST00000091967.8 ENSMUST00000091967.9 NM_001083334 Q6P1B9 Q6P1B9_MOUSE uc008eji.1 uc008eji.2 uc008eji.3 cytoplasm regulation of endocytosis uc008eji.1 uc008eji.2 uc008eji.3 
ENSMUST00000091996.4 Or10p22 ENSMUST00000091996.4 olfactory receptor family 10 subfamily P member 22 (from RefSeq NM_146861.2) 10P22_MOUSE ENSMUST00000091996.1 ENSMUST00000091996.2 ENSMUST00000091996.3 Mor269-3 NM_146861 Olfr9 Or10p22 Q60885 Q8VGC0 uc007hpf.1 uc007hpf.2 uc007hpf.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hpf.1 uc007hpf.2 uc007hpf.3 
ENSMUST00000092033.4 Rbms2 ENSMUST00000092033.4 RNA binding motif, single stranded interacting protein 2, transcript variant 1 (from RefSeq NM_019711.2) ENSMUST00000092033.1 ENSMUST00000092033.2 ENSMUST00000092033.3 NM_019711 Q8VC70 RBMS2_MOUSE uc007hlm.1 uc007hlm.2 uc007hlm.3 Nucleus nucleic acid binding RNA binding nucleus ribonucleoprotein complex uc007hlm.1 uc007hlm.2 uc007hlm.3 
ENSMUST00000092041.11 Ss18 ENSMUST00000092041.11 SS18, subunit of BAF chromatin remodeling complex, transcript variant 2 (from RefSeq NM_001161369.1) ENSMUST00000092041.1 ENSMUST00000092041.10 ENSMUST00000092041.2 ENSMUST00000092041.3 ENSMUST00000092041.4 ENSMUST00000092041.5 ENSMUST00000092041.6 ENSMUST00000092041.7 ENSMUST00000092041.8 ENSMUST00000092041.9 NM_001161369 Q8BJJ6 Q8BJJ6_MOUSE Ss18 uc008edf.1 uc008edf.2 uc008edf.3 Belongs to the SS18 family. transcription coactivator activity positive regulation of nucleic acid-templated transcription uc008edf.1 uc008edf.2 uc008edf.3 
ENSMUST00000092058.4 Rdh16f2 ENSMUST00000092058.4 RDH16 family member 2 (from RefSeq NM_145424.2) BC089597 ENSMUST00000092058.1 ENSMUST00000092058.2 ENSMUST00000092058.3 NM_145424 Q8K3M1 Q8K3M1_MOUSE Rdh16f2 uc011xpw.1 uc011xpw.2 uc011xpw.3 Belongs to the short-chain dehydrogenases/reductases (SDR) family. endoplasmic reticulum membrane oxidoreductase activity integral component of organelle membrane intracellular membrane-bounded organelle androsterone dehydrogenase activity androstan-3-alpha,17-beta-diol dehydrogenase activity oxidation-reduction process uc011xpw.1 uc011xpw.2 uc011xpw.3 
ENSMUST00000092070.13 Lama3 ENSMUST00000092070.13 laminin, alpha 3, transcript variant 1 (from RefSeq NM_010680.2) E9PUR4 ENSMUST00000092070.1 ENSMUST00000092070.10 ENSMUST00000092070.11 ENSMUST00000092070.12 ENSMUST00000092070.2 ENSMUST00000092070.3 ENSMUST00000092070.4 ENSMUST00000092070.5 ENSMUST00000092070.6 ENSMUST00000092070.7 ENSMUST00000092070.8 ENSMUST00000092070.9 LAMA3_MOUSE NM_010680 O08751 Q61788 Q61789 Q61966 Q9JHQ7 uc008ecf.1 uc008ecf.2 uc008ecf.3 uc008ecf.4 uc008ecf.5 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes. Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein), laminin-6 (laminin-311 or K-laminin) and laminin-7 (laminin-321 or KS- laminin). Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. Event=Alternative splicing; Named isoforms=2; Name=B; IsoId=Q61789-1; Sequence=Displayed; Name=A; IsoId=Q61789-2; Sequence=VSP_003038, VSP_003039; Basal membrane of the upper alimentary tract and urinary and nasal epithelia, salivary glands and teeth (both variants). Isoform A is predominantly expressed in skin, hair follicles and developing neurons of the trigeminal ganglion. Isoform B was found in bronchi, alveoli, stomach, intestinal crypts, whisker pads, CNS, telencephalic neuroectoderm, thalamus, Rathke pouch and periventricular subependymal germinal layer. The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. Domains IV and G are globular. Sequence=CAA58837.1; Type=Frameshift; Evidence=; morphogenesis of a polarized epithelium receptor binding integrin binding extracellular matrix structural constituent extracellular region basement membrane laminin-3 complex laminin-5 complex endoplasmic reticulum cell-cell adherens junction cell adhesion integrin-mediated signaling pathway animal organ morphogenesis tissue development cell migration hemidesmosome regulation of cell adhesion regulation of cell migration hemidesmosome assembly endodermal cell differentiation regulation of embryonic development cell-cell adhesion uc008ecf.1 uc008ecf.2 uc008ecf.3 uc008ecf.4 uc008ecf.5 
ENSMUST00000092074.12 Stat6 ENSMUST00000092074.12 signal transducer and activator of transcription 6 (from RefSeq NM_009284.2) ENSMUST00000092074.1 ENSMUST00000092074.10 ENSMUST00000092074.11 ENSMUST00000092074.2 ENSMUST00000092074.3 ENSMUST00000092074.4 ENSMUST00000092074.5 ENSMUST00000092074.6 ENSMUST00000092074.7 ENSMUST00000092074.8 ENSMUST00000092074.9 NM_009284 P52633 Q8R2F1 STAT6_MOUSE uc007hka.1 uc007hka.2 uc007hka.3 Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif (By similarity). P52633; Q2EMV9: Parp14; NbExp=3; IntAct=EBI-647085, EBI-1534943; Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4. Tyrosine phosphorylated following stimulation by IL3/interleukin-3. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling. Mono-ADP-ribosylated by PARP14. Belongs to the transcription factor STAT family. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding T-helper 1 cell lineage commitment negative regulation of type 2 immune response DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated defense response signal transduction JAK-STAT cascade cytokine-mediated signaling pathway protein phosphatase binding nuclear membrane mammary gland epithelial cell proliferation response to cytokine interleukin-4-mediated signaling pathway regulation of cell proliferation identical protein binding response to peptide hormone sequence-specific DNA binding membrane raft positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgE isotypes JAK-STAT cascade involved in growth hormone signaling pathway mammary gland morphogenesis cellular response to hydrogen peroxide cellular response to reactive nitrogen species uc007hka.1 uc007hka.2 uc007hka.3 
ENSMUST00000092089.6 Mcidas ENSMUST00000092089.6 multiciliate differentiation and DNA synthesis associated cell cycle protein (from RefSeq NM_001037914.4) ENSMUST00000092089.1 ENSMUST00000092089.2 ENSMUST00000092089.3 ENSMUST00000092089.4 ENSMUST00000092089.5 Gm6320 Idas MCIN_MOUSE Mci Mcin NM_001037914 Q3UZ45 uc007rxa.1 uc007rxa.2 uc007rxa.3 Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1. Heterodimer (via coiled-coil domain) with GMNN (via coiled- coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN. Nucleus Note=Excluded from the nucleolus. At 12.5 dpc expression is restricted to the developing mouse brain. High levels are detected in the cortical hem and the choroid plexus epithelium in the telencephalic midline by cells starting to differentiate (at protein level). Belongs to the geminin family. transcription coactivator activity nucleus regulation of DNA replication cell cycle regulation of mitotic cell cycle nuclear body cell projection organization identical protein binding motile cilium assembly positive regulation of transcription from RNA polymerase II promoter cilium assembly centriole assembly multi-ciliated epithelial cell differentiation uc007rxa.1 uc007rxa.2 uc007rxa.3 
ENSMUST00000092096.14 Usp14 ENSMUST00000092096.14 ubiquitin specific peptidase 14, transcript variant 1 (from RefSeq NM_021522.4) ENSMUST00000092096.1 ENSMUST00000092096.10 ENSMUST00000092096.11 ENSMUST00000092096.12 ENSMUST00000092096.13 ENSMUST00000092096.2 ENSMUST00000092096.3 ENSMUST00000092096.4 ENSMUST00000092096.5 ENSMUST00000092096.6 ENSMUST00000092096.7 ENSMUST00000092096.8 ENSMUST00000092096.9 NM_021522 Q543U5 Q923F2 Q9D0L0 Q9JMA1 UBP14_MOUSE uc008ean.1 uc008ean.2 uc008ean.3 Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:16190881). Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (By similarity). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (PubMed:19726649). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (By similarity). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS and KDM4D (By similarity). Cytoplasm Cell membrane ; Peripheral membrane protein Belongs to the peptidase C19 family. USP14/UBP6 subfamily. proteasome complex immune system process thiol-dependent ubiquitin-specific protease activity endopeptidase inhibitor activity protein binding cytoplasm cytosol plasma membrane proteolysis ubiquitin-dependent protein catabolic process chemical synaptic transmission peptidase activity cysteine-type peptidase activity cell surface negative regulation of endopeptidase activity membrane protein deubiquitination hydrolase activity cytoplasmic vesicle thiol-dependent ubiquitinyl hydrolase activity innate immune response synapse regulation of chemotaxis regulation of proteasomal protein catabolic process proteasome binding negative regulation of ER-associated ubiquitin-dependent protein catabolic process uc008ean.1 uc008ean.2 uc008ean.3 
ENSMUST00000092123.11 Epc2 ENSMUST00000092123.11 enhancer of polycomb homolog 2 (from RefSeq NM_172663.4) A2AQU9 ENSMUST00000092123.1 ENSMUST00000092123.10 ENSMUST00000092123.2 ENSMUST00000092123.3 ENSMUST00000092123.4 ENSMUST00000092123.5 ENSMUST00000092123.6 ENSMUST00000092123.7 ENSMUST00000092123.8 ENSMUST00000092123.9 EPC2_MOUSE NM_172663 Q3URX9 Q80Y70 Q8BXC5 Q8C0I4 uc008jpw.1 uc008jpw.2 uc008jpw.3 uc008jpw.4 May play a role in transcription or DNA repair. Nucleus Belongs to the enhancer of polycomb family. Sequence=BAC33197.1; Type=Erroneous initiation; Evidence=; nucleus DNA repair chromatin organization regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus histone acetylation Piccolo NuA4 histone acetyltransferase complex NuA4 histone acetyltransferase complex histone acetyltransferase activity uc008jpw.1 uc008jpw.2 uc008jpw.3 uc008jpw.4 
ENSMUST00000092143.12 Msrb3 ENSMUST00000092143.12 methionine sulfoxide reductase B3, transcript variant 1 (from RefSeq NM_177092.5) A0A0R4J139 A0A0R4J139_MOUSE ENSMUST00000092143.1 ENSMUST00000092143.10 ENSMUST00000092143.11 ENSMUST00000092143.2 ENSMUST00000092143.3 ENSMUST00000092143.4 ENSMUST00000092143.5 ENSMUST00000092143.6 ENSMUST00000092143.7 ENSMUST00000092143.8 ENSMUST00000092143.9 Msrb3 NM_177092 uc007hfh.1 uc007hfh.2 uc007hfh.3 uc007hfh.4 uc007hfh.5 Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. Reaction=[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]- dithiol + L-methionine (R)-S-oxide; Xref=Rhea:RHEA:21260, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57844, ChEBI:CHEBI:58773; EC=1.8.4.14; Evidence=; Reaction=[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]; Xref=Rhea:RHEA:24164, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12314, ChEBI:CHEBI:15377, ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:45764, ChEBI:CHEBI:50058; EC=1.8.4.12; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Belongs to the MsrB Met sulfoxide reductase family. mitochondrion endoplasmic reticulum response to oxidative stress zinc ion binding oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor protein repair peptide-methionine (R)-S-oxide reductase activity metal ion binding oxidation-reduction process uc007hfh.1 uc007hfh.2 uc007hfh.3 uc007hfh.4 uc007hfh.5 
ENSMUST00000092154.10 Rnpc3 ENSMUST00000092154.10 RNA-binding region (RNP1, RRM) containing 3, transcript variant 1 (from RefSeq NM_001038696.1) ENSMUST00000092154.1 ENSMUST00000092154.2 ENSMUST00000092154.3 ENSMUST00000092154.4 ENSMUST00000092154.5 ENSMUST00000092154.6 ENSMUST00000092154.7 ENSMUST00000092154.8 ENSMUST00000092154.9 Kiaa1839 NM_001038696 Q3TTZ2 Q3UZ01 Q69Z94 Q80VS9 Q91YJ1 Q9CSC1 RNPC3_MOUSE Rbm40 uc008rbd.1 uc008rbd.2 Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA (By similarity). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UZ01-1; Sequence=Displayed; Name=2; IsoId=Q3UZ01-2; Sequence=VSP_029402; Sequence=AAH16603.1; Type=Erroneous initiation; Evidence=; mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus nucleoplasm U12-type spliceosomal complex U12 snRNA binding pre-mRNA intronic binding uc008rbd.1 uc008rbd.2 
ENSMUST00000092155.12 Col11a1 ENSMUST00000092155.12 collagen, type XI, alpha 1 (from RefSeq NM_007729.3) COBA1_MOUSE ENSMUST00000092155.1 ENSMUST00000092155.10 ENSMUST00000092155.11 ENSMUST00000092155.2 ENSMUST00000092155.3 ENSMUST00000092155.4 ENSMUST00000092155.5 ENSMUST00000092155.6 ENSMUST00000092155.7 ENSMUST00000092155.8 ENSMUST00000092155.9 NM_007729 Q61245 Q64047 Q80WR4 uc008rbk.1 uc008rbk.2 uc008rbk.3 uc008rbk.4 This gene encodes the alpha-1 subunit of type XI collagen, one of the low abundance fibrillar collagens that is essential for normal embryonic skeletal development and the cohesive properties of cartilage. The encoded protein, in association with the alpha-1 subunit of type II collagen, forms a heterotrimeric type XI procollagen that undergoes proteolytic processing. Mice lacking the encoded protein develop severe chondrodysplasia and die at birth. [provided by RefSeq, Dec 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK157734.1, D38162.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. Trimers composed of three different chains: alpha 1(XI), alpha 2(XI), and alpha 3(XI). Alpha 3(XI) is a post-translational modification of alpha 1(II). Alpha 1(V) can also be found instead of alpha 3(XI)=1(II) (By similarity). Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q61245-1; Sequence=Displayed; Name=Short; IsoId=Q61245-2; Sequence=VSP_001147; The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity). Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. N-glycosylated. Note=Defects in Col11a1 are associated with chondrodysplasia, an autosomal recessive disease characterized by skeletal defects caused by abnormalities in the cartilage of limbs, ribs, mandibles and trachea. Belongs to the fibrillar collagen family. cartilage condensation ossification chondrocyte development heart morphogenesis extracellular matrix structural constituent extracellular region collagen trimer collagen type XI trimer extracellular space proteoglycan metabolic process visual perception sensory perception of sound heparin binding extracellular matrix structural constituent conferring tensile strength extracellular matrix organization collagen fibril organization extracellular matrix endodermal cell differentiation tendon development inner ear morphogenesis metal ion binding embryonic skeletal system morphogenesis skeletal system morphogenesis detection of mechanical stimulus involved in sensory perception of sound cartilage development ventricular cardiac muscle tissue morphogenesis heparan sulfate binding uc008rbk.1 uc008rbk.2 uc008rbk.3 uc008rbk.4 
ENSMUST00000092162.7 Lyz1 ENSMUST00000092162.7 lysozyme 1 (from RefSeq NM_013590.4) ENSMUST00000092162.1 ENSMUST00000092162.2 ENSMUST00000092162.3 ENSMUST00000092162.4 ENSMUST00000092162.5 ENSMUST00000092162.6 LYZ1_MOUSE Lzp-s NM_013590 P17897 uc007hdc.1 uc007hdc.2 uc007hdc.3 uc007hdc.4 Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz1 is active against a range of Gram-positive and Gram-negative bacteria. Less effective than Lyz2 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria. Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17; Monomer. Secreted. Expressed strongly only in small intestine. Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides. Belongs to the glycosyl hydrolase 22 family. Golgi cis cisterna lysozyme activity catalytic activity extracellular region extracellular space cytoplasm endoplasmic reticulum lumen Golgi stack microvillus metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds cytolysis trans-Golgi network transport vesicle secretory granule defense response to bacterium identical protein binding rough endoplasmic reticulum lumen defense response to Gram-negative bacterium defense response to Gram-positive bacterium uc007hdc.1 uc007hdc.2 uc007hdc.3 uc007hdc.4 
ENSMUST00000092163.9 Lyz2 ENSMUST00000092163.9 lysozyme 2 (from RefSeq NM_017372.3) ENSMUST00000092163.1 ENSMUST00000092163.2 ENSMUST00000092163.3 ENSMUST00000092163.4 ENSMUST00000092163.5 ENSMUST00000092163.6 ENSMUST00000092163.7 ENSMUST00000092163.8 LYZ2_MOUSE Lyz Lyzs NM_017372 P08905 Q3TXG2 Q3U5Q2 Q3U690 Q8VE78 uc007hda.1 uc007hda.2 uc007hda.3 Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz2 is active against a range of Gram-positive and Gram-negative bacteria. More effective than Lyz1 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria. Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17; pH dependence: Optimum pH is 5. ; Monomer. Secreted. Expressed weakly in myeloblasts, moderately in immature macrophages, and strongly in both mature macrophages and macrophage-rich tissues. Mice display increased inflammation in response to M.luteus infection, impaired digestion of M.luteus cell walls, decreased clearance of P.aeruginosa from infected airways, increased susceptibility to K.pneumoniae infection and increased bacterial burden and mortality following infection with various Gram-negative bacteria. Lyz2 is non-immunogenic in wild-type mice but is rendered immunogenic in mutants. Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides. Belongs to the glycosyl hydrolase 22 family. Sequence=BAE30022.1; Type=Erroneous initiation; Evidence=; Sequence=BAE31835.1; Type=Erroneous initiation; Evidence=; Sequence=BAE34954.1; Type=Erroneous initiation; Evidence=; Golgi cis cisterna lysozyme activity catalytic activity extracellular region extracellular space cytoplasm endoplasmic reticulum lumen Golgi stack microvillus metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds cytolysis trans-Golgi network transport vesicle secretory granule defense response to bacterium identical protein binding rough endoplasmic reticulum lumen defense response to Gram-negative bacterium defense response to Gram-positive bacterium uc007hda.1 uc007hda.2 uc007hda.3 
ENSMUST00000092167.7 Ptprb ENSMUST00000092167.7 protein tyrosine phosphatase receptor type B (from RefSeq NM_029928.2) B2RU80 ENSMUST00000092167.1 ENSMUST00000092167.2 ENSMUST00000092167.3 ENSMUST00000092167.4 ENSMUST00000092167.5 ENSMUST00000092167.6 NM_029928 PTPRB_MOUSE Q3UGZ7 Q8CIW2 uc007hbv.1 uc007hbv.2 uc007hbv.3 uc007hbv.4 Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Monomer (By similarity). Interacts with TEK (PubMed:10557082, PubMed:19451274). Interacts via fibronectin type-III 17 domain with CDH5 (PubMed:19015309). Detected in a complex with CNTN1 and NRCAM (PubMed:11564762). Interacts (phosphorylated form) with FYN and GRB2 (PubMed:20398064). Membrane ; Single-pass type I membrane protein Expression is very high in the vasculature of lung, spleen, and kidney, as well as in the heart valves, and is also present in the endothelium of arterioles and venules. Also expressed in tumor vasculature. Expressed in both arterial and venous vascular endothelium in embryos, although more strongly in arterial vessels. Highly expressed in the developing outflow tract of the heart and later is expressed in developing heart valves. Mice show severe cardiovascular defects and embryonic lethality by 10 dpc. Vasculogenesis occurs normally however, angiogenesis is abnormal. Angiogenic defects are most pronounced in the yolk sac and include a complete failure to elaborate the primitive vascular scaffold into higher-order branched arteries, veins, and capillaries. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. angiogenesis phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding protein dephosphorylation membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation receptor complex cadherin binding uc007hbv.1 uc007hbv.2 uc007hbv.3 uc007hbv.4 
ENSMUST00000092170.7 Tmem19 ENSMUST00000092170.7 transmembrane protein 19, transcript variant 2 (from RefSeq NM_133683.4) ENSMUST00000092170.1 ENSMUST00000092170.2 ENSMUST00000092170.3 ENSMUST00000092170.4 ENSMUST00000092170.5 ENSMUST00000092170.6 NM_133683 Q3UU09 Q8BY23 Q8BZK7 Q91W52 TMM19_MOUSE uc287uxu.1 uc287uxu.2 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91W52-1; Sequence=Displayed; Name=2; IsoId=Q91W52-2; Sequence=VSP_024661; Belongs to the TMEM19 family. molecular_function biological_process membrane integral component of membrane uc287uxu.1 uc287uxu.2 
ENSMUST00000092175.4 Kcnc2 ENSMUST00000092175.4 potassium voltage gated channel, Shaw-related subfamily, member 2, transcript variant 5 (from RefSeq NM_001379644.1) ENSMUST00000092175.1 ENSMUST00000092175.2 ENSMUST00000092175.3 KCNC2_MOUSE Kcnc2 NM_001379644 Q14B80 uc007hao.1 uc007hao.2 uc007hao.3 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system (PubMed:10561420, PubMed:10414303, PubMed:11124984, PubMed:10903572, PubMed:11506885, PubMed:15317859, PubMed:15917463, PubMed:17761775, PubMed:21414897). Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly (PubMed:10414303). Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (By similarity). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:10531438, PubMed:12000114). Channel properties may be modulated by either the association with ancillary subunits, such as KCNE1, KCNE2 and KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in thalamocortical and suprachiasmatic nucleus (SCN) neurons, in hippocampal and neocortical interneurons and in retinal ganglion cells (PubMed:10561420, PubMed:10903572, PubMed:11506885, PubMed:17761775). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation- dependent manner (PubMed:10903572). Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release (PubMed:15917463). Required for long-range synchronization of gamma oscillations over distance in the neocortex (PubMed:22539821). Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (PubMed:21414897). Inhibited by millimolar levels of tetraethylammonium (TEA). Contrary to other channels, inhibited only by millimolar levels of 4-aminopyridine (4-AP). Inhibited by Stichodactyla helianthus peptide ShK. Kinetic parameters: Note=Homotetrameric channels expressed in xenopus oocytes or in mammalian non-neuronal cells display delayed-rectifier voltage- dependent potassium currents, that are rapidly activated during membrane depolarization, i.e within a risetime of a few msec. After that, inactivates very slowly, i.e within about >800 msec. Their activation requires a threshold potential at about -10 mV, with a midpoint activation at about 12.1 mV and a steepness parameter of about 8.4 mV. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system, the presence or absence of ancillary subunits and post-translational modifications. ; Homotetramer and heterotetramer with other channel-forming alpha subunits, such as KCNC1 (PubMed:10531438). Interacts with KCNC1 (PubMed:10531438, PubMed:12000114). Homotetramer or heterotetramer channel activity is regulated by association with modulating ancillary subunits such as KCNE1, KCNE2 and KCNE3, creating a functionally diverse range of channel complexes. Interacts with KCNE1, KCNE2 and KCNE3 (By similarity). Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Perikaryon ll projection, axon Cell projection, dendrite stsynaptic cell membrane Presynaptic cell membrane Synapse, synaptosome Synapse Apical cell membrane Basolateral cell membrane Note=Colocalizes with parvalbumin in globus pallidus neurons. Localizes in thalamocortical axons and synapses (By similarity). Localizes on the surface of cell somata, proximal dendrites and axonal membranes (PubMed:12000114, PubMed:10903572). Also detected throughout the neuropil (PubMed:12000114). Localized in starburst cell somata and proximal dendrite processes (PubMed:15317859). Colocalized with GABA in presynaptic terminals (PubMed:10531438). Clustered in patches in somatic and proximal dendritic membrane as well as in axons and presnypatic terminals of GABAergic interneurons; some of these patches are found near postsynaptic sites (PubMed:10531438). Weakly expressed in the brain at postnatal age day 7 (P7) and increased at P60 (PubMed:21912965). Not detectable in newborn hippocampus. Expressed weakly at P7 in the early developing hippocampus, increasing progressively and reaching a plateau of expression at P14 that is maintained throughout P51. Expressed in paravalbumin- and somatostain-containing inhibitory interneurons of the hippocampus; in the CA1/CA3 stratum oriens-alveus and stratum pyramidale and in cells within the hilus and subgranular layer of the dentate gyrus (DG) (PubMed:12000114, PubMed:10903572). Strongly expressed in parvalbumin (PV)-containing fast-spiking GABAergic inhibitor interneurons in deep cortical layers V and VI (PubMed:10531438). Also expressed in non-fast-spiking calbindin (CB)- and/or somatostatin (SOM)-containing interneurons in deep cortical layers V and VI (PubMed:10531438). Expressed in starburst amacrine cells of the retina in the inner nuclear layer (INL) and ganglion cell layer (GCL) (PubMed:15317859). Expressed in the suprachiasmatic nucleus (SCN) (at protein level) (PubMed:15852012, PubMed:21414897). Expressed in the early developing brain, increasing progressively until P14 (PubMed:21912965). Weakly expressed in the brain at 14 dpc (at protein level) (PubMed:21912965). Expressed in the brain at 14 dpc (PubMed:21912965). The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. Phosphorylated by PKA in cortical synaptosomes. cAMP-dependent phosphorylation inhibits channel activity (By similarity). Histamine H2 receptor- and PKA-induced phosphorylation extends action potential spike duration, reduces action potential spike amplitude, sustains maximum firing frequency in hippocampal interneurons; also reduces the incidence of high-frequency oscillations in hippocampal CA3 pyramidal cell layers (PubMed:10903572). Mice are healthy, grow normally, are fertile and show no evidence of severe sensory or motor abnormalities (PubMed:11124984). Show increased seizure susceptibility and reduced long-range synchronization of gamma oscillations over distance in the neocortex (PubMed:22539821). Thalamocortical neurons show a strong attenuation in maximal peak firing rates, with larger spikes and slower action potential repolarization (PubMed:17761775). Neocortical GABAergic interneurons display broader spikes and sustain lower trains of high-frequency spikes without accommodation or spike doublets in rapid succession (PubMed:11124984, PubMed:22539821). Histamine H2 receptor- and PKA-induced hippocampal inhibitory interneurons display no maximal sustainable firing frequency modulation (PubMed:10903572). Double knockout of KCNC2 and KCNC1 exhibited disrupted daily rhythms in wheel-running behavior (PubMed:21414897). Display smaller outward currents and slower deactivation in starburst amacrine cells compared with KCNC2 knockout mice (PubMed:15317859). Neocortical GABAergic interneuron terminals display also a reduced rate of spike repolarization, broader spike, increased calcium influx and release of GABA neurotransmitter (PubMed:15917463). Suprachiasmatic nucleus (SCN) neurons display a reduction in the magnitude of fast delayed rectifier potassium currents, wider action potentials, reduced spontaneous firing activity during the day and reduced NMDA-evoked increase firing responses during the night (PubMed:21414897). Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. action potential ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity protein binding plasma membrane integral component of plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane basolateral plasma membrane apical plasma membrane cell junction axon dendrite axolemma vesicle dendrite membrane neuronal cell body membrane ion transmembrane transport regulation of ion transmembrane transport nitric oxide-cGMP-mediated signaling pathway presynaptic membrane cell projection neuron projection neuronal cell body terminal bouton perikaryon ion channel binding synapse postsynaptic membrane protein homooligomerization protein heterooligomerization transmembrane transport cellular response to nitric oxide potassium ion transmembrane transport cellular response to toxic substance regulation of presynaptic membrane potential voltage-gated ion channel activity involved in regulation of presynaptic membrane potential positive regulation of potassium ion transmembrane transport positive regulation of voltage-gated potassium channel activity uc007hao.1 uc007hao.2 uc007hao.3 
ENSMUST00000092295.10 Mbd3 ENSMUST00000092295.10 methyl-CpG binding domain protein 3, transcript variant 1 (from RefSeq NM_013595.3) ENSMUST00000092295.1 ENSMUST00000092295.2 ENSMUST00000092295.3 ENSMUST00000092295.4 ENSMUST00000092295.5 ENSMUST00000092295.6 ENSMUST00000092295.7 ENSMUST00000092295.8 ENSMUST00000092295.9 MBD3_MOUSE NM_013595 Q792D3 Q8CFJ1 Q9Z2D8 uc007gdb.1 uc007gdb.2 uc007gdb.3 uc007gdb.4 This gene encodes a member of the MBD family of nuclear proteins that contain a methyl-CpG binding domain (MBD). The encoded protein is a component of the nucleosome remodeling and histone deacetylation (NuRD) complex. Deletion of this gene causes embryonic lethality in mice. Embryonic stem cells lacking the encoded protein are severely compromised in their ability to differentiate and fail to commit to developmental lineages in the absence of leukemia inhibitory factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Acts as transcriptional repressor and plays a role in gene silencing (By similarity). Does not bind methylated DNA by itself (PubMed:9774669). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (By similarity). Recruits histone deacetylases and DNA methyltransferases (By similarity). Heterodimer (via N-terminus) with MBD2 (By similarity). Component of the MeCP1 histone deacetylase complex (By similarity). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (By similarity). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (By similarity). Interacts with MBD3L2 (via N-terminus); the interaction is direct (By similarity). Interacts with BCL6 (By similarity). Interacts with CDK2AP1 (By similarity). Interacts with HDAC1 (By similarity). Interacts with MTA2 (By similarity). Interacts with DNMT1 (By similarity). Interacts with GATAD2A (By similarity). Interacts with GATAD2B (By similarity). Does not interact with PWWP2A (PubMed:30228260, PubMed:30327463). Does not interact with PWWP2B (PubMed:30228260). Q9Z2D8; P14404: Mecom; NbExp=4; IntAct=EBI-1994548, EBI-1994523; Q9Z2D8-1; P14404: Mecom; NbExp=5; IntAct=EBI-1994598, EBI-1994523; Nucleus romosome Note=Detected on chromatin, at promoter regions of active genes (By similarity). Nuclear, in discrete foci (PubMed:9774669). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z2D8-1; Sequence=Displayed; Name=2; IsoId=Q9Z2D8-2; Sequence=VSP_011082; Highly expressed in brain, heart, kidney, liver, lung, skeletal muscle, spleen and testis. Detected at lower levels in embryonic stem cells. negative regulation of transcription from RNA polymerase II promoter chromatin heterochromatin in utero embryonic development DNA binding chromatin binding protein binding nucleus nucleoplasm chromosome cytoplasm methylation-dependent chromatin silencing brain development heart development aging methyl-CpG binding tissue development response to organic cyclic compound histone acetylation NuRD complex response to nutrient levels response to estradiol macromolecular complex regulation of DNA methylation embryonic organ development nucleolus uc007gdb.1 uc007gdb.2 uc007gdb.3 uc007gdb.4 
ENSMUST00000092298.6 Zfp750 ENSMUST00000092298.6 zinc finger protein 750 (from RefSeq NM_178763.4) B1ATU1 B9EKG8 ENSMUST00000092298.1 ENSMUST00000092298.2 ENSMUST00000092298.3 ENSMUST00000092298.4 ENSMUST00000092298.5 NM_178763 Q66JP3 Q8BH05 Q8C0L1 ZN750_MOUSE Znf750 uc007mvz.1 uc007mvz.2 uc007mvz.3 uc007mvz.4 Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression (By similarity). Nucleus RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleus epidermis development cell differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding promoter-specific chromatin binding uc007mvz.1 uc007mvz.2 uc007mvz.3 uc007mvz.4 
ENSMUST00000092325.11 Plppr3 ENSMUST00000092325.11 phospholipid phosphatase related 3, transcript variant 1 (from RefSeq NM_181681.3) A0A0R3P9D0 A0A0R3P9D0_MOUSE ENSMUST00000092325.1 ENSMUST00000092325.10 ENSMUST00000092325.2 ENSMUST00000092325.3 ENSMUST00000092325.4 ENSMUST00000092325.5 ENSMUST00000092325.6 ENSMUST00000092325.7 ENSMUST00000092325.8 ENSMUST00000092325.9 NM_181681 Plppr3 uc007gaf.1 uc007gaf.2 Membrane ; Multi- pass membrane protein Belongs to the PA-phosphatase related phosphoesterase family. membrane integral component of membrane uc007gaf.1 uc007gaf.2 
ENSMUST00000092351.6 Cacng8 ENSMUST00000092351.6 calcium channel, voltage-dependent, gamma subunit 8 (from RefSeq NM_133190.3) Cacng8 ENSMUST00000092351.1 ENSMUST00000092351.2 ENSMUST00000092351.3 ENSMUST00000092351.4 ENSMUST00000092351.5 F7CZ64 F7CZ64_MOUSE NM_133190 uc291knz.1 uc291knz.2 Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Membrane ulti-pass membrane protein Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. voltage-gated ion channel activity calcium channel activity ion transport calcium ion transport membrane integral component of membrane regulation of ion transmembrane transport calcium ion transmembrane transport uc291knz.1 uc291knz.2 
ENSMUST00000092366.4 Tspear ENSMUST00000092366.4 thrombospondin type laminin G domain and EAR repeats (from RefSeq NM_001287074.1) ENSMUST00000092366.1 ENSMUST00000092366.2 ENSMUST00000092366.3 J3S6Y1 NM_001287074 Q8BUQ8 Q8K4Y9 TSEAR_MOUSE Tnep1 Tspear uc011xhl.1 uc011xhl.2 uc011xhl.3 Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system. Secreted Cell surface Cell projection, stereocilium Note=Secreted protein which may bind to the cell surface via a membrane receptor. Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=J3S6Y1-1; Sequence=Displayed; Name=2 ; IsoId=J3S6Y1-2; Sequence=VSP_044543, VSP_044544; Name=3 ; IsoId=J3S6Y1-3; Sequence=VSP_044542; In the organ of Corti, expression at postnatal day 1 (P1) is restricted to the basal region of the stereocilia of inner and outer hair cells (at protein level). Expressed in the organ of Corti at P1 and P7, in cochlear ganglion, stria vascularis and vestibular ends at P7, and in inferior colliculus, remaining brainstem, cerebellum, brain hemispheres and retina at P1, P7 and in the adult. Also detected in adult liver, lung, kidney, intestine and testis but not in heart or skeletal muscle. Sequence=CAD31788.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function extracellular region sensory perception of sound regulation of Notch signaling pathway cell surface stereocilium tooth mineralization cell projection ciliary membrane uc011xhl.1 uc011xhl.2 uc011xhl.3 
ENSMUST00000092369.4 Krtap10-4 ENSMUST00000092369.4 keratin associated protein 10-4 (from RefSeq NM_001135991.1) 675238 ENSMUST00000092369.1 ENSMUST00000092369.2 ENSMUST00000092369.3 Krtap10-4 LOC675238 NM_001135991 Q08EG8 Q08EG8_MOUSE uc007fwd.1 uc007fwd.2 uc007fwd.3 uc007fwd.4 cellular_component intermediate filament biological_process identical protein binding keratin filament uc007fwd.1 uc007fwd.2 uc007fwd.3 uc007fwd.4 
ENSMUST00000092370.3 Krtap12-1 ENSMUST00000092370.3 keratin associated protein 12-1 (from RefSeq NM_010670.1) ENSMUST00000092370.1 ENSMUST00000092370.2 KR121_MOUSE Krtap12-1 NM_010670 Q9Z287 uc007fwc.1 uc007fwc.2 uc007fwc.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). Interacts with hair keratins. Expressed only in the head and back skin of a 3 day old mouse. Not expressed in adult skin. Belongs to the KRTAP type 12 family. molecular_function intermediate filament biological_process keratin filament uc007fwc.1 uc007fwc.2 uc007fwc.3 
ENSMUST00000092371.5 Krtap12-23 ENSMUST00000092371.5 predicted gene 10272 (from RefSeq NM_001384208.1) ENSMUST00000092371.1 ENSMUST00000092371.2 ENSMUST00000092371.3 ENSMUST00000092371.4 F7CZ33 F7CZ33_MOUSE Gm10272 NM_001384208 uc011xhi.1 uc011xhi.2 uc011xhi.3 molecular_function cellular_component intermediate filament biological_process keratin filament uc011xhi.1 uc011xhi.2 uc011xhi.3 
ENSMUST00000092382.10 Usp36 ENSMUST00000092382.10 ubiquitin specific peptidase 36 (from RefSeq NM_001033528.1) B1AQJ2 ENSMUST00000092382.1 ENSMUST00000092382.2 ENSMUST00000092382.3 ENSMUST00000092382.4 ENSMUST00000092382.5 ENSMUST00000092382.6 ENSMUST00000092382.7 ENSMUST00000092382.8 ENSMUST00000092382.9 Kiaa1453 NM_001033528 Q6ZPQ7 UBP36_MOUSE uc011yim.1 uc011yim.2 Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability (PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (By similarity). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (By similarity). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (By similarity). Deubiquitinates SOD2, regulates SOD2 protein stability (By similarity). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (By similarity). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (By similarity). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (By similarity). Binds to pre-rRNAs (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with isoform 3 of FBXW7; the interaction inhibits MYC degradation induced by SCF(FBW7) complex. Interacts with NTRK1; USP36 does not deubiquitinate NTRK1. Interacts with NEDD4L (via domains WW1, 3 and 4); the interaction inhibits ubiquitination of, at least, NTRK1, KCNQ2 and KCNQ3 by NEDD4L. Interacts (via C-terminus) with EXOSC10 (via C-terminus); the interaction is facilitated by the association with RNA and promotes sumoylation of EXOSC10 (By similarity). Nucleus, nucleolus Cytoplasm Polyubiquitinated by NEDD4L, no effect on USP36 protein levels. Both proteins interact with and regulate each other's ubiquitination levels. Embryonic lethality (PubMed:29273634). Embryos show apoptosis at the morula stage, blocking the transition from morula to blastocysts during embryonic development (PubMed:29273634). Belongs to the peptidase C19 family. Sequence=BAC98173.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus nucleolus cytoplasm proteolysis ubiquitin-dependent protein catabolic process nucleolus organization peptidase activity cysteine-type peptidase activity negative regulation of macroautophagy histone deubiquitination protein deubiquitination nuclear speck hydrolase activity regulation of protein stability thiol-dependent ubiquitinyl hydrolase activity regulation of apoptotic process protein stabilization regulation of rRNA processing uc011yim.1 uc011yim.2 
ENSMUST00000092394.4 Gm11733 ENSMUST00000092394.4 predicted gene 11733 (from RefSeq NR_130966.1) ENSMUST00000092394.1 ENSMUST00000092394.2 ENSMUST00000092394.3 NR_130966 uc056ypf.1 uc056ypf.2 uc056ypf.3 uc056ypf.4 uc056ypf.1 uc056ypf.2 uc056ypf.3 uc056ypf.4 
ENSMUST00000092404.13 Srsf2 ENSMUST00000092404.13 serine and arginine-rich splicing factor 2 (from RefSeq NM_011358.2) ENSMUST00000092404.1 ENSMUST00000092404.10 ENSMUST00000092404.11 ENSMUST00000092404.12 ENSMUST00000092404.2 ENSMUST00000092404.3 ENSMUST00000092404.4 ENSMUST00000092404.5 ENSMUST00000092404.6 ENSMUST00000092404.7 ENSMUST00000092404.8 ENSMUST00000092404.9 NM_011358 Pr264 Q542L3 Q60701 Q62093 SRSF2_MOUSE Sfrs10 Sfrs2 uc007mmn.1 uc007mmn.2 uc007mmn.3 uc007mmn.4 The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK086103.1, AK088042.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA (By similarity). Can bind to the myelin basic protein (MBP) gene MB3 regulatory region and increase transcription of the mbp promoter in cells derived from the CNS. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity). Interacts with CCNL1 and CCNL2. Interacts with SCAF11. Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus) (By similarity). In vitro, self-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with BRDT. Q62093; Q99J95: Cdk9; NbExp=3; IntAct=EBI-2550402, EBI-2654963; Q62093; Q8R409: Hexim1; NbExp=4; IntAct=EBI-2550402, EBI-6261031; Q62093; P08775: Polr2a; NbExp=3; IntAct=EBI-2550402, EBI-2549849; Nucleus Nucleus, nucleoplasm Nucleus speckle Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear speckle to nucleoplasm. Expressed in all the tissues examined; liver, kidney, spleen, heart, lung and brain. Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by SRPK2 and this causes its redistribution from the nuclear speckle to nucleoplasm and controls cell fate decision in response to cisplatin treatment. KAT5/TIP60 inhibits its phosphorylation by preventing SRPK2 nuclear translocation (By similarity). Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation. This effect is counterbalanced by HDAC6, which positively controls SRSF2 protein level by deacetylating it and preventing its proteasomal degradation (By similarity). Belongs to the splicing factor SR family. Sequence=AAA64595.1; Type=Frameshift; Evidence=; mitotic cell cycle regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding protein kinase C binding protein binding nucleus nucleoplasm spliceosomal complex cytosol mRNA processing RNA splicing nuclear speck response to vitamin E interchromatin granule pre-mRNA binding mRNA cis splicing, via spliceosome uc007mmn.1 uc007mmn.2 uc007mmn.3 uc007mmn.4 
ENSMUST00000092426.5 Ccdc153 ENSMUST00000092426.5 coiled-coil domain containing 153, transcript variant 1 (from RefSeq NM_001081369.3) CC153_MOUSE ENSMUST00000092426.1 ENSMUST00000092426.2 ENSMUST00000092426.3 ENSMUST00000092426.4 NM_001081369 P0C7Q1 uc012gru.1 uc012gru.2 uc012gru.3 Belongs to the UPF0610 family. molecular_function cellular_component biological_process uc012gru.1 uc012gru.2 uc012gru.3 
ENSMUST00000092430.11 Tfam ENSMUST00000092430.11 transcription factor A, mitochondrial (from RefSeq NM_009360.4) ENSMUST00000092430.1 ENSMUST00000092430.10 ENSMUST00000092430.2 ENSMUST00000092430.3 ENSMUST00000092430.4 ENSMUST00000092430.5 ENSMUST00000092430.6 ENSMUST00000092430.7 ENSMUST00000092430.8 ENSMUST00000092430.9 Hmgts NM_009360 P40630 P97894 P97906 Q543I8 Q9DBM9 TFAM_MOUSE Tfam uc007fom.1 uc007fom.2 uc007fom.3 [Isoform Mitochondrial]: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (By similarity). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (By similarity). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (By similarity). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (By similarity). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (By similarity). Is able to unwind DNA (By similarity). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (By similarity). Required for maintenance of normal levels of mitochondrial DNA (PubMed:9500544). May play a role in organizing and compacting mitochondrial DNA (PubMed:17581862). [Isoform Nuclear]: May also function as a transcriptional activator or may have a structural role in the compaction of nuclear DNA during spermatogenesis. Monomer; binds DNA as a monomer. Homodimer. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT. In this complex TFAM recruits POLRMT to the promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Upon metabolic stress, forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT. Interacts with TFB1M and TFB2M. Interacts with CLPX; this enhances DNA-binding. [Isoform Mitochondrial]: Mitochondrion Mitochondrion matrix, mitochondrion nucleoid [Isoform Nuclear]: Nucleus Event=Alternative splicing; Named isoforms=2; Name=Mitochondrial; IsoId=P40630-1; Sequence=Displayed; Name=Nuclear; IsoId=P40630-2; Sequence=VSP_002185, VSP_002186; The mitochondrial isoform is widely expressed while the nuclear isoform is testis-specific. Binds DNA via its HMG boxes. When bound to the mitochondrial light strand promoter, bends DNA into a U-turn shape, each HMG box bending the DNA by 90 degrees (By similarity). Phosphorylation by PKA within the HMG box 1 impairs DNA binding and promotes degradation by the AAA+ Lon protease. Embryonic lethal, due to absence of mitochondrial DNA. Mutant embryos die before 10.5 dpc. Sequence=AAA02579.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AK004857; Type=Frameshift; Evidence=; mitochondrial RNA polymerase regulatory region DNA binding transcription coactivator binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus mitochondrion mitochondrial matrix transcription from mitochondrial promoter transcription initiation from mitochondrial promoter DNA binding, bending heat shock protein binding macromolecular complex mitochondrial respiratory chain complex assembly mitochondrial nucleoid sequence-specific DNA binding positive regulation of transcription, DNA-templated uc007fom.1 uc007fom.2 uc007fom.3 
ENSMUST00000092459.4 Cd300ld3 ENSMUST00000092459.4 CD300 molecule like family member D3 (from RefSeq NM_199201.2) CLM3_MOUSE Cd300ld3 Cd300lh Clm3 ENSMUST00000092459.1 ENSMUST00000092459.2 ENSMUST00000092459.3 Lmir7 NM_199201 Q6SJQ5 uc057kmv.1 uc057kmv.2 uc057kmv.3 Acts as an activating receptor inducing cytokine production in mast cells. Can act as a positive regulator of TLR9 signaling in macrophages, leading to enhanced production of pro-inflammatory cytokines. Interacts with FCER1G; the interaction may be indirect. Interacts with TLR9. Cell membrane ; Single-pass type I membrane protein Early endosome Lysosome Highly expressed in bone marrow-derived mast cells and macrophages, peripheral blood monocytes and CD11c+ cells, with weaker expression detected in CD11b cells in bone marrow and peripheral blood. Not detected in B220+ cells in bone marrow or spleen, in Thy- 1.2+ or CD3+ cells in peripheral blood, spleen or thymus, or in NK1.1+ cells in spleen (at protein level). Widely expressed in various tissues including heart, liver, spleen, lung, kidney, brain, bone marrow, thymus, axillary lymph node and mesenteric lymph node. Highly expressed in macrophage cell lines J774.1 and RAW 264.7 and in mast cell line MC/9. Weak expression detected in B-lineage cell lines WEHI-231 and A20 and in dendritic cell line DC2.4. Not detected in other myeloid cell lines or T-lineage cell lines. Down-regulated in macrophages by single-stranded CpG oligodeoxynucleotide stimulation. Belongs to the CD300 family. immune system process protein binding lysosome endosome early endosome plasma membrane membrane integral component of membrane positive regulation of protein ubiquitination positive regulation of toll-like receptor 9 signaling pathway uc057kmv.1 uc057kmv.2 uc057kmv.3 
ENSMUST00000092464.10 Cd300c2 ENSMUST00000092464.10 CD300C molecule 2 (from RefSeq NM_134158.1) CLM4_MOUSE Cd300c Cd300c2 Clm4 ENSMUST00000092464.1 ENSMUST00000092464.2 ENSMUST00000092464.3 ENSMUST00000092464.4 ENSMUST00000092464.5 ENSMUST00000092464.6 ENSMUST00000092464.7 ENSMUST00000092464.8 ENSMUST00000092464.9 Igsf7 Lmir2 NM_134158 Q7TN55 Q7TSN2 Q8JZM5 uc007mge.1 uc007mge.2 uc007mge.3 Acts as an activating receptor in mast cells and macrophages. Interacts with TYROBP, HCST and FcR gamma. Cell membrane ingle-pass type I membrane protein Present on the surface of mast cells, dendritic cells, peritoneal macrophages and a subset of B-cells (at protein level). Belongs to the CD300 family. immune system process protein binding plasma membrane membrane integral component of membrane positive regulation of cytokine secretion uc007mge.1 uc007mge.2 uc007mge.3 
ENSMUST00000092466.13 Cd300c ENSMUST00000092466.13 CD300C molecule (from RefSeq NM_001368239.1) Cd300c D3Z6G7 D3Z6G7_MOUSE ENSMUST00000092466.1 ENSMUST00000092466.10 ENSMUST00000092466.11 ENSMUST00000092466.12 ENSMUST00000092466.2 ENSMUST00000092466.3 ENSMUST00000092466.4 ENSMUST00000092466.5 ENSMUST00000092466.6 ENSMUST00000092466.7 ENSMUST00000092466.8 ENSMUST00000092466.9 NM_001368239 uc288djg.1 uc288djg.2 uc288djg.3 membrane integral component of membrane uc288djg.1 uc288djg.2 uc288djg.3 
ENSMUST00000092486.11 Adamts14 ENSMUST00000092486.11 ADAM metallopeptidase with thrombospondin type 1 motif 14, transcript variant 2 (from RefSeq NR_157278.1) Adamts14 B2RXX5 B2RXX5_MOUSE ENSMUST00000092486.1 ENSMUST00000092486.10 ENSMUST00000092486.2 ENSMUST00000092486.3 ENSMUST00000092486.4 ENSMUST00000092486.5 ENSMUST00000092486.6 ENSMUST00000092486.7 ENSMUST00000092486.8 ENSMUST00000092486.9 NR_157278 uc007ffu.1 uc007ffu.2 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix Lacks conserved residue(s) required for the propagation of feature annotation. metalloendopeptidase activity extracellular region proteolysis integrin-mediated signaling pathway peptidase activity metallopeptidase activity collagen fibril organization uc007ffu.1 uc007ffu.2 
ENSMUST00000092491.7 Vmn2r111 ENSMUST00000092491.7 vomeronasal 2, receptor 111 (from RefSeq NM_001104573.1) ENSMUST00000092491.1 ENSMUST00000092491.2 ENSMUST00000092491.3 ENSMUST00000092491.4 ENSMUST00000092491.5 ENSMUST00000092491.6 K7N674 K7N674_MOUSE NM_001104573 Vmn2r111 uc009vbo.1 uc009vbo.2 uc009vbo.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vbo.1 uc009vbo.2 uc009vbo.3 
ENSMUST00000092498.12 Sgpl1 ENSMUST00000092498.12 sphingosine phosphate lyase 1, transcript variant 3 (from RefSeq NM_001316674.1) ENSMUST00000092498.1 ENSMUST00000092498.10 ENSMUST00000092498.11 ENSMUST00000092498.2 ENSMUST00000092498.3 ENSMUST00000092498.4 ENSMUST00000092498.5 ENSMUST00000092498.6 ENSMUST00000092498.7 ENSMUST00000092498.8 ENSMUST00000092498.9 NM_001316674 O54955 Q8C942 Q8R0X7 SGPL1_MOUSE Sgpl1 Spl uc007ffl.1 uc007ffl.2 uc007ffl.3 uc007ffl.4 Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (PubMed:9464245, PubMed:20097939). Elevates stress-induced ceramide production and apoptosis (PubMed:9464245). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts (PubMed:20097939, PubMed:28262793). Involved in the regulation of pro- inflammatory response and neutrophil trafficking (PubMed:21173151). Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (PubMed:28521611). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). Reaction=sphinganine 1-phosphate = hexadecanal + phosphoethanolamine; Xref=Rhea:RHEA:18593, ChEBI:CHEBI:17600, ChEBI:CHEBI:57939, ChEBI:CHEBI:58190; EC=4.1.2.27; Evidence=; Reaction=sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamine; Xref=Rhea:RHEA:33507, ChEBI:CHEBI:17585, ChEBI:CHEBI:58190, ChEBI:CHEBI:60119; EC=4.1.2.27; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Lipid metabolism; sphingolipid metabolism. Endoplasmic reticulum membrane ; Single-pass type III membrane protein ; Cytoplasmic side Highest levels are found in liver, small intestine and thymus, followed by kidney, lung, heart, spleen and brain (at protein level). Also detected in stomach, testis and skeletal muscle (at protein level). Expressed throughout mouse embryogenesis.A transient increase is observed from 5.5 dpc to 7.5 dpc. Mutant animals have a shortened lifespan (PubMed:21173151). Mutant mice show an increase of sphingoid base phosphates, but also other sphingolipids (including sphingosine, ceramide, and sphingomyelin) in the serum and/or liver, resulting in changes in the levels of serum and liver lipids not directly within the sphingolipid pathway, including phospholipids, triacyglycerol, diacylglycerol, and cholesterol (PubMed:20097939). They are deficient in B and T lymphocytes yet have high blood levels of neutrophils and monocytes along with elevated expression of pro-inflammatory cytokines. Their tissues are largely clear of infiltrating leukocytes and their neutrophils are defective in migration to chemotactic stimulus (PubMed:21173151). Mice lacking Sgpl1 exhibit complete podocyte foot process effacement and absence of slit diaphragms in kidney (PubMed:9464245, PubMed:28165339). They display hypoalbuminemia and an elevated urinary albumin/creatinine ratio (PubMed:28165339). They also display abnormal adrenal gland morphology and defective expression of enzymes involved in steroidogenesis in this tissue (PubMed:28165343). Conditional knockout in brain significantly reduces phosphoethanolamine levels with alterations in basal and stimulated autophagy involving decreased conversion of LC3-I to LC3-II, increased levels of lysosomal markers and aggregate-prone proteins such as APP and SNCA. Animals show profound deficits in cognitive skills (PubMed:28521611). Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily. luteinization vasculogenesis ameboidal-type cell migration kidney development catalytic activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process sphingolipid metabolic process ceramide metabolic process nitrogen compound metabolic process apoptotic process spermatogenesis sphinganine-1-phosphate aldolase activity androgen metabolic process estrogen metabolic process female gonad development post-embryonic development fibroblast migration membrane integral component of membrane lyase activity carboxy-lyase activity carboxylic acid metabolic process hemopoiesis sphingolipid catabolic process pyridoxal phosphate binding Leydig cell differentiation regulation of multicellular organism growth platelet-derived growth factor receptor signaling pathway skeletal system morphogenesis palate development face morphogenesis apoptotic signaling pathway uc007ffl.1 uc007ffl.2 uc007ffl.3 uc007ffl.4 
ENSMUST00000092517.9 Smurf2 ENSMUST00000092517.9 SMAD specific E3 ubiquitin protein ligase 2, transcript variant 1 (from RefSeq NM_025481.3) A2A5Z6 A2A5Z7 ENSMUST00000092517.1 ENSMUST00000092517.2 ENSMUST00000092517.3 ENSMUST00000092517.4 ENSMUST00000092517.5 ENSMUST00000092517.6 ENSMUST00000092517.7 ENSMUST00000092517.8 NM_025481 Q5IRE6 SMUF2_MOUSE Smurf2 uc007lzx.1 uc007lzx.2 uc007lzx.3 uc007lzx.4 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF- beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation. SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation. Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence=; Activated by NDFIP1- and NDFIP2-binding. Protein modification; protein ubiquitination. Interacts (via WW domains) with SMAD1. Interacts (via WW domains) with SMAD2 (via PY-motif). Interacts (via WW domains) with SMAD3 (via PY-motif). Interacts with SMAD6. Interacts with SMAD7 (via PY-motif) and TGFBR1; SMAD7 recruits SMURF2 to the TGF-beta receptor and regulates its degradation. Does not interact with SMAD4; SMAD4 lacks a PY-motif. Interacts with AIMP1 (By similarity). Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase (By similarity). Interacts with TTC3 (By similarity). A2A5Z6; O14641: DVL2; Xeno; NbExp=8; IntAct=EBI-2348309, EBI-740850; Nucleus Cytoplasm Cell membrane Membrane raft Note=Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2A5Z6-1; Sequence=Displayed; Name=2; IsoId=A2A5Z6-2; Sequence=VSP_036055, VSP_036056; Up-regulated about ten-fold by activation of the TNF- signaling pathway in vitro. The second and third WW domains are responsible for interaction with the PY-motif of R-SMAD (SMAD1, SMAD2 and SMAD3). The C2 domain is involved in autoinhibition of the catalytic activity by interacting with the HECT domain. Auto-ubiquitinated and ubiquitinated in the presence of RNF11 and UBE2D1 (By similarity). Ubiquitinated by the SCF(FBXL15) complex and TTC3, leading to its degradation by the proteasome (By similarity). 'Lys-48'-linked polyubiquitination mediated by TRAF4 at Lys-119 leads to SMURF2 proteasomal degradation (By similarity). Level decreases under the suppression of SCYE1, suggesting that AIMP1 stabilizes SMURF2. ubiquitin ligase complex protein polyubiquitination ubiquitin-protein transferase activity transforming growth factor beta receptor binding protein binding nucleus cytoplasm cytosol plasma membrane ubiquitin-dependent protein catabolic process membrane protein ubiquitination nuclear speck transferase activity negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway ubiquitin-dependent SMAD protein catabolic process identical protein binding proteasome-mediated ubiquitin-dependent protein catabolic process membrane raft positive regulation of protein catabolic process SMAD binding ubiquitin protein ligase activity positive regulation of trophoblast cell migration uc007lzx.1 uc007lzx.2 uc007lzx.3 uc007lzx.4 
ENSMUST00000092566.8 Slc16a10 ENSMUST00000092566.8 solute carrier family 16 (monocarboxylic acid transporters), member 10, transcript variant 1 (from RefSeq NM_001114332.1) ENSMUST00000092566.1 ENSMUST00000092566.2 ENSMUST00000092566.3 ENSMUST00000092566.4 ENSMUST00000092566.5 ENSMUST00000092566.6 ENSMUST00000092566.7 MOT10_MOUSE Mct10 NM_001114332 Q3TNJ1 Q3U9N9 Q3UAN9 Q8BWR7 Tat1 uc007ewm.1 uc007ewm.2 uc007ewm.3 uc007ewm.4 Sodium- and proton-independent thyroid hormones and aromatic acids transporter. Mediates both uptake and efflux of 3,5,3'- triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (By similarity). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:16245314). Plays an important role in homeostasis of aromatic amino acids (PubMed:23045339). Reaction=L-tryptophan(in) = L-tryptophan(out); Xref=Rhea:RHEA:70947, ChEBI:CHEBI:57912; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70948; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70949; Evidence=; Reaction=L-tyrosine(in) = L-tyrosine(out); Xref=Rhea:RHEA:68572, ChEBI:CHEBI:58315; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68573; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68574; Evidence=; Reaction=L-phenylalanine(in) = L-phenylalanine(out); Xref=Rhea:RHEA:27950, ChEBI:CHEBI:58095; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27951; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:27952; Evidence=; Reaction=3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L- thyronine(in); Xref=Rhea:RHEA:71811, ChEBI:CHEBI:533015; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71812; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71813; Evidence=; Reaction=L-thyroxine(out) = L-thyroxine(in); Xref=Rhea:RHEA:71819, ChEBI:CHEBI:58448; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71820; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71821; Evidence=; Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Note=Detected in basolateral membrane of kidney proximal tubule starting at he beginning of the proximal tubule epithelium within the glomerular capsule and extending to the S1 and S2 segments. Localizes also to the basolateral membrane of small intestine enterocytes and to sinusoidal side of perivenous hepatocytes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U9N9-1; Sequence=Displayed; Name=2; IsoId=Q3U9N9-2; Sequence=VSP_030252, VSP_030253; Highly expressed in small intestine, particularly in jejunum and ileum, scarcely in colon and substantially in kidney, liver and skeletal muscle (PubMed:16245314). In the brain expression is low and appears to be restricted to a subset of neurons, microglia cells, and oligodendrocytes (PubMed:24994998). Not N-glycosylated. Deficient mice grow and reproduce normally, show no gross phenotype and no obvious neurological defect. Deficient mice, however, display increased plasma, muscle and kidney aromatic amino acids (AAA) concentration under both normal and high protein diet, although this concentration remains normal in the liver, but it does not alter thyroid hormones homeostasis. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. Sequence=BAE38097.1; Type=Erroneous initiation; Evidence=; plasma membrane integral component of plasma membrane thyroid hormone generation monocarboxylic acid transmembrane transporter activity aromatic amino acid transmembrane transporter activity thyroid hormone transmembrane transporter activity monocarboxylic acid transport aromatic amino acid transport membrane integral component of membrane basolateral plasma membrane transmembrane transport thyroid hormone transport thyroid-stimulating hormone secretion uc007ewm.1 uc007ewm.2 uc007ewm.3 uc007ewm.4 
ENSMUST00000092567.11 Gjc1 ENSMUST00000092567.11 gap junction protein, gamma 1, transcript variant 3 (from RefSeq NM_001159383.1) CXG1_MOUSE Cxn-45 ENSMUST00000092567.1 ENSMUST00000092567.10 ENSMUST00000092567.2 ENSMUST00000092567.3 ENSMUST00000092567.4 ENSMUST00000092567.5 ENSMUST00000092567.6 ENSMUST00000092567.7 ENSMUST00000092567.8 ENSMUST00000092567.9 Gja7 NM_001159383 P28229 uc007lsn.1 uc007lsn.2 uc007lsn.3 uc007lsn.4 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Interacts with CNST. P28229; P23242: Gja1; NbExp=2; IntAct=EBI-1767271, EBI-298630; Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Belongs to the connexin family. Gamma-type subfamily. vasculogenesis ion channel activity gap junction channel activity protein binding plasma membrane gap junction connexin complex cell communication cell-cell signaling chemical synaptic transmission heart development visual perception membrane integral component of membrane gap junction assembly cell junction ion transmembrane transport cell development cardiac muscle tissue development transmembrane transport AV node cell to bundle of His cell communication by electrical coupling gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling uc007lsn.1 uc007lsn.2 uc007lsn.3 uc007lsn.4 
ENSMUST00000092569.13 Ccdc43 ENSMUST00000092569.13 coiled-coil domain containing 43 (from RefSeq NM_025918.3) CCD43_MOUSE D11Ertd707e ENSMUST00000092569.1 ENSMUST00000092569.10 ENSMUST00000092569.11 ENSMUST00000092569.12 ENSMUST00000092569.2 ENSMUST00000092569.3 ENSMUST00000092569.4 ENSMUST00000092569.5 ENSMUST00000092569.6 ENSMUST00000092569.7 ENSMUST00000092569.8 ENSMUST00000092569.9 NM_025918 Q6PDT2 Q9CR29 uc007lsg.1 uc007lsg.2 uc007lsg.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CR29-1; Sequence=Displayed; Name=2; IsoId=Q9CR29-2; Sequence=VSP_018336, VSP_018337; Belongs to the CCDC43 family. molecular_function cytosol biological_process uc007lsg.1 uc007lsg.2 uc007lsg.3 
ENSMUST00000092584.6 Marcks ENSMUST00000092584.6 myristoylated alanine rich protein kinase C substrate (from RefSeq NM_008538.2) ENSMUST00000092584.1 ENSMUST00000092584.2 ENSMUST00000092584.3 ENSMUST00000092584.4 ENSMUST00000092584.5 MARCS_MOUSE Macs NM_008538 P26645 uc007evg.1 uc007evg.2 uc007evg.3 MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. P26645; P62158: CALM3; Xeno; NbExp=2; IntAct=EBI-911805, EBI-397435; Cytoplasm, cytoskeleton Membrane ; Lipid-anchor Brain, spleen, less in kidney and heart, and very low levels in liver. By lipopolysaccharides (LPS). Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity. Belongs to the MARCKS family. actin binding protein kinase C binding calmodulin binding cytoplasm centrosome cytoskeleton cell cortex membrane actin filament bundle germinal vesicle identical protein binding actin filament binding actin filament bundle assembly protein homooligomerization actin crosslink formation uc007evg.1 uc007evg.2 uc007evg.3 
ENSMUST00000092618.10 Aup1 ENSMUST00000092618.10 ancient ubiquitous protein 1, transcript variant 1 (from RefSeq NM_007517.5) Aup1 ENSMUST00000092618.1 ENSMUST00000092618.2 ENSMUST00000092618.3 ENSMUST00000092618.4 ENSMUST00000092618.5 ENSMUST00000092618.6 ENSMUST00000092618.7 ENSMUST00000092618.8 ENSMUST00000092618.9 NM_007517 Q3U3K9 Q3U3K9_MOUSE uc009cly.1 uc009cly.2 uc009cly.3 uc009cly.4 uc009cly.5 The protein encoded by this gene contains several conserved domains including a hydrophobic domain, an acetyltransferase domain, a ubiquitin binding domain, and a domain required for recruitment of ubiquitin-conjugating enzyme E2 G2 (Ube2g2). In humans, this protein localizes to the endoplasmic reticulum and to lipid droplets. This protein is thought to be involved both in the degradation of misfolded proteins from the endoplasmic reticulum and in the storage of neutral lipids. Reduced expression of the human ortholog of this gene strongly reduces lipid droplet clustering in the cell, and causes stabilization of misfolded proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. Endoplasmic reticulum membrane ; Peripheral membrane protein Lipid droplet Membrane ; Peripheral membrane protein Belongs to the AUP1 family. cytoplasm membrane integral component of membrane retrograde protein transport, ER to cytosol uc009cly.1 uc009cly.2 uc009cly.3 uc009cly.4 uc009cly.5 
ENSMUST00000092623.5 Rspo3 ENSMUST00000092623.5 R-spondin 3 (from RefSeq NM_028351.3) A6H6M4 ENSMUST00000092623.1 ENSMUST00000092623.2 ENSMUST00000092623.3 ENSMUST00000092623.4 NM_028351 Q2TJ95 Q3SYI9 Q5R2V4 Q8BVW2 Q9CSB2 RSPO3_MOUSE uc007etb.1 uc007etb.2 uc007etb.3 uc007etb.4 uc007etb.5 Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis (PubMed:16543246, PubMed:21693646, PubMed:26766444). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:16543246, PubMed:21693646). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non- canonical Wnt signaling pathway in endothelial cells (PubMed:26766444, PubMed:16543246, PubMed:21693646). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity). Interacts with the extracellular domain of FZD8 and LRP6 (PubMed:16543246). It however does not form a ternary complex with FZD8 and LRP6 (PubMed:16543246). Interacts with WNT1 (PubMed:16543246). Binds heparin. Interacts with LGR4, LGR5 and LGR6 (PubMed:21693646). Secreted Highly expressed in endothelial cells (PubMed:26766444). Expressed from day 7.5 in the primitive streak. At day 9.5, it is expressed in various neural and mesodermal derivatives, mainly along dorsal neural tube, diencephalon, somites and tailbud mesoderm. Strongly expressed in limb buds, particularly in the morphogenetically active region such as the apical ectodermal ridge (AER). The FU repeats are required for activation and stabilization of beta-catenin. Embryonic lethality due to vascular remodeling defects (PubMed:26766444). Conditional knockout in endothelial cells results in impaired developmental and tumor vascular remodeling. Mice show endothelial cell apoptosis and vascular pruning, leading to reduced microvessel density (PubMed:26766444). Belongs to the R-spondin family. Sequence=BAC36296.1; Type=Frameshift; Evidence=; angiogenesis blood vessel remodeling sprouting angiogenesis receptor binding frizzled binding extracellular region heparin binding Wnt signaling pathway positive regulation of Wnt signaling pathway response to stimulus limb development branching involved in labyrinthine layer morphogenesis positive regulation of canonical Wnt signaling pathway positive regulation of non-canonical Wnt signaling pathway uc007etb.1 uc007etb.2 uc007etb.3 uc007etb.4 uc007etb.5 
ENSMUST00000092627.6 9330159F19Rik ENSMUST00000092627.6 RIKEN cDNA 9330159F19 gene (from RefSeq NM_001162537.2) 9330159F19Rik D3Z623 D3Z623_MOUSE ENSMUST00000092627.1 ENSMUST00000092627.2 ENSMUST00000092627.3 ENSMUST00000092627.4 ENSMUST00000092627.5 NM_001162537 uc011xcd.1 uc011xcd.2 uc011xcd.3 molecular_function cellular_component biological_process uc011xcd.1 uc011xcd.2 uc011xcd.3 
ENSMUST00000092629.4 Mtcl3 ENSMUST00000092629.4 MTCL family member 3 (from RefSeq NM_026138.2) ENSMUST00000092629.1 ENSMUST00000092629.2 ENSMUST00000092629.3 MTCL3_MOUSE NM_026138 Q6NZL0 Q8BLM2 Q9CSN3 Q9CU45 Soga3 uc007est.1 uc007est.2 uc007est.3 uc007est.4 Membrane ; Single-pass membrane protein Belongs to the MTCL family. Sequence=AAH66079.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC31794.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component extracellular space biological_process regulation of autophagy membrane integral component of membrane uc007est.1 uc007est.2 uc007est.3 uc007est.4 
ENSMUST00000092639.12 Lama2 ENSMUST00000092639.12 laminin, alpha 2 (from RefSeq NM_008481.3) ENSMUST00000092639.1 ENSMUST00000092639.10 ENSMUST00000092639.11 ENSMUST00000092639.2 ENSMUST00000092639.3 ENSMUST00000092639.4 ENSMUST00000092639.5 ENSMUST00000092639.6 ENSMUST00000092639.7 ENSMUST00000092639.8 ENSMUST00000092639.9 F8VQ43 LAMA2_MOUSE NM_008481 Q05003 Q60675 Q64061 uc033fpa.1 uc033fpa.2 uc033fpa.3 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-2 is a subunit of laminin-2 (laminin-211 or merosin), laminin-4 (laminin-221 or S-merosin) and laminin-12 (laminin-213). Interacts with FBLN1, FBLN2 and NID2. Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. Domains VI, IV and G are globular. Note=Defects in Lama2 are a cause of murine muscular dystrophy (dy2J). Sequence=AAC52165.1; Type=Frameshift; Evidence=; receptor binding extracellular matrix structural constituent extracellular region basement membrane extracellular space cell adhesion axon guidance animal organ morphogenesis tissue development Schwann cell differentiation regulation of cell adhesion regulation of cell migration neuromuscular junction positive regulation of synaptic transmission, cholinergic sarcolemma synaptic cleft dendritic spine regulation of embryonic development uc033fpa.1 uc033fpa.2 uc033fpa.3 
ENSMUST00000092654.4 Taar8b ENSMUST00000092654.4 trace amine-associated receptor 8B (from RefSeq NM_001010837.1) B2RT24 ENSMUST00000092654.1 ENSMUST00000092654.2 ENSMUST00000092654.3 Gm1149 NM_001010837 Q5QD06 TAA8B_MOUSE uc007eqp.1 uc007eqp.2 Orphan olfactory receptor specific for trace amines. Cell membrane ; Multi-pass membrane protein Specifically expressed in neurons of the olfactory epithelium. Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2- phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled amine receptor activity membrane integral component of membrane uc007eqp.1 uc007eqp.2 
ENSMUST00000092656.4 Taar7e ENSMUST00000092656.4 trace amine-associated receptor 7E (from RefSeq NM_001010835.1) ENSMUST00000092656.1 ENSMUST00000092656.2 ENSMUST00000092656.3 Gm697 NM_001010835 Q5QD09 TAA7E_MOUSE uc007eqm.1 uc007eqm.2 Orphan olfactory receptor specific for trace amines. Cell membrane ; Multi-pass membrane protein Specifically expressed in neurons of the olfactory epithelium. Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2- phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled amine receptor activity membrane integral component of membrane uc007eqm.1 uc007eqm.2 
ENSMUST00000092657.2 Taar7d ENSMUST00000092657.2 trace amine-associated receptor 7D (from RefSeq NM_001010838.1) ENSMUST00000092657.1 NM_001010838 Q5QD10 TAA7D_MOUSE uc007eql.1 uc007eql.2 Orphan olfactory receptor specific for trace amines. Cell membrane ; Multi-pass membrane protein Specifically expressed in neurons of the olfactory epithelium. Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2- phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled amine receptor activity membrane integral component of membrane uc007eql.1 uc007eql.2 
ENSMUST00000092658.2 Taar7b ENSMUST00000092658.2 trace amine-associated receptor 7B (from RefSeq NM_001010827.1) ENSMUST00000092658.1 Gm698 NM_001010827 Q5QD11 TAA7B_MOUSE uc007eqk.1 uc007eqk.2 Orphan olfactory receptor specific for trace amines. Cell membrane ; Multi-pass membrane protein Specifically expressed in neurons of the olfactory epithelium. Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2- phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled amine receptor activity membrane integral component of membrane uc007eqk.1 uc007eqk.2 
ENSMUST00000092659.4 Taar5 ENSMUST00000092659.4 trace amine-associated receptor 5 (from RefSeq NM_001009574.1) ENSMUST00000092659.1 ENSMUST00000092659.2 ENSMUST00000092659.3 Gm227 NM_001009574 Q5QD14 TAAR5_MOUSE uc007eqh.1 uc007eqh.2 Olfactory receptor specific for trimethylamine, a trace amine enriched in the urine of male mice, playing a role in social behavior. Trimethylamine is present at high concentration in the urine of male mice after puberty and acts as an attractant. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase. Cell membrane ; Multi-pass membrane protein Specifically expressed in neurons of the olfactory epithelium, to discrete glomeruli predominantly localized to a confined bulb region. Present in the dorsal area of the main olfactory epithelium. Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2- phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine. Trimethylamine is a bacterial metabolite found in some animal odors, and is a repulsive odor associated with bad breath and spoiled food for most organisms, except for M.musculus, where it acts as an attractant (PubMed:16878137, PubMed:23177478). Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity transmembrane signaling receptor activity G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway sensory perception of chemical stimulus behavior mating behavior G-protein coupled amine receptor activity membrane integral component of membrane social behavior trimethylamine receptor activity uc007eqh.1 uc007eqh.2 
ENSMUST00000092660.2 Taar4 ENSMUST00000092660.2 trace amine-associated receptor 4 (from RefSeq NM_001008499.1) ENSMUST00000092660.1 Gm226 NM_001008499 Q5QD15 TAAR4_MOUSE uc007eqg.1 uc007eqg.2 Olfactory receptor specific for 2-phenylethylamine, a trace amine present at high concentration in the urine of carnivore species, playing a key role in fear and avoidance responses. 2-phenylethylamine acts as a kairomone in the chemical detection of carnivore odor and triggers fear in mice. This receptor is probably mediated by the G(s)- class of G-proteins which activate adenylate cyclase. Cell membrane; Multi-pass membrane protein. Specifically expressed in neurons of the olfactory epithelium, to discrete glomeruli predominantly localized to a confined bulb region. Present in the dorsal area of the main olfactory epithelium. Mice lacking Taar4 show an absence of aversion to low concentrations of volatile amines and to the odor of predator urine. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity behavioral fear response G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus behavior chemosensory behavior G-protein coupled amine receptor activity membrane integral component of membrane 2-phenylethylamine receptor activity uc007eqg.1 uc007eqg.2 
ENSMUST00000092665.12 Eya4 ENSMUST00000092665.12 EYA transcriptional coactivator and phosphatase 4, transcript variant 1 (from RefSeq NM_010167.5) ENSMUST00000092665.1 ENSMUST00000092665.10 ENSMUST00000092665.11 ENSMUST00000092665.2 ENSMUST00000092665.3 ENSMUST00000092665.4 ENSMUST00000092665.5 ENSMUST00000092665.6 ENSMUST00000092665.7 ENSMUST00000092665.8 ENSMUST00000092665.9 Eya4 NM_010167 Q8BY78 Q8BY78_MOUSE uc007ept.1 uc007ept.2 uc007ept.3 Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Note=Binds 1 Mg(2+) ion per subunit. Nucleus Belongs to the HAD-like hydrolase superfamily. EYA family. phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein dephosphorylation multicellular organism development sensory perception of sound transcription factor binding hydrolase activity peptidyl-tyrosine dephosphorylation metal ion binding inner ear development uc007ept.1 uc007ept.2 uc007ept.3 
ENSMUST00000092671.12 Stat3 ENSMUST00000092671.12 signal transducer and activator of transcription 3, transcript variant 2 (from RefSeq NM_213660.3) A2A5D1 Aprf B7ZC17 ENSMUST00000092671.1 ENSMUST00000092671.10 ENSMUST00000092671.11 ENSMUST00000092671.2 ENSMUST00000092671.3 ENSMUST00000092671.4 ENSMUST00000092671.5 ENSMUST00000092671.6 ENSMUST00000092671.7 ENSMUST00000092671.8 ENSMUST00000092671.9 NM_213660 P42227 STAT3_MOUSE Stat3 uc007lmq.1 uc007lmq.2 uc007lmq.3 uc007lmq.4 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]. Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (By similarity). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (By similarity). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (By similarity). Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (By similarity). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (PubMed:12594516). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:16825198). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (PubMed:20215569). Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (PubMed:23401489). Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity). Interacts with ARL2BP; interaction is enhanced with ARL2. Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear. Interacts with BMX. Interacts with ZIPK/DAPK3. Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. In prostate cancer cells, interacts with PRKCE and promotes DNA binding activity of STAT3. Interacts with STMN3, antagonizing its microtubule- destabilizing activity. Interacts with the 'Lys-129' acetylated form of BIRC5/survivin. Interacts with FER. Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain) (By similarity). Interacts with FGFR4 (By similarity). Interacts with INPP5F; the interaction is independent of STAT3 Tyr-705 phosphorylation status (By similarity). Interacts with OCAD1 (PubMed:23972987). Interacts (unphosphorylated or phosphorylated at Ser-727) with PHB1 (By similarity). Interacts and may form heterodimers with NHLH1 (PubMed:18356286). Found in a complex with SLC39A6, SLC39A10 and with the 'Ser-727' phosphorylated form of STAT3 throughout mitosis (By similarity). P42227; Q80VH0: Bank1; NbExp=4; IntAct=EBI-602878, EBI-646949; P42227; Q64261: Cdk6; NbExp=3; IntAct=EBI-602878, EBI-847380; P42227; P23927: Cryab; NbExp=3; IntAct=EBI-602878, EBI-299046; P42227; O54784: Dapk3; NbExp=8; IntAct=EBI-602878, EBI-77359; P42227; P70424: Erbb2; NbExp=4; IntAct=EBI-602878, EBI-2945468; P42227; O35387: Hax1; NbExp=11; IntAct=EBI-602878, EBI-642449; P42227; Q00175: Pgr; NbExp=4; IntAct=EBI-602878, EBI-346821; P42227; P42227: Stat3; NbExp=3; IntAct=EBI-602878, EBI-602878; P42227; P48025: Syk; NbExp=5; IntAct=EBI-602878, EBI-300116; P42227; P30084: ECHS1; Xeno; NbExp=3; IntAct=EBI-602878, EBI-719602; P42227; Q8TAE8: GADD45GIP1; Xeno; NbExp=3; IntAct=EBI-602878, EBI-372506; P42227; P40189: IL6ST; Xeno; NbExp=4; IntAct=EBI-602878, EBI-1030834; P42227; Q9NRF2: SH2B1; Xeno; NbExp=5; IntAct=EBI-602878, EBI-310491; Cytoplasm Nucleus Note=Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 (By similarity). Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Event=Alternative splicing; Named isoforms=3; Name=Stat3A; IsoId=P42227-1; Sequence=Displayed; Name=Stat3B; IsoId=P42227-2; Sequence=VSP_006287; Name=Del-701; IsoId=P42227-3; Sequence=VSP_010475; STAT3A is seen in the liver, spleen, and kidney. STAT3B is also detected in the liver, although in a much less abundant manner. Expressed in the lung and an increase in expression levels seen during methicillin-resistant S.aureus infection. Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, CNTF, LIF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha, LEP and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Tyrosine phosphorylated upon stimulation with EGF. Upon LPS challenge, phosphorylated within the nucleus by IRAK1 (By similarity). Upon UV-A treatment, phosphorylated on Ser-727 by RPS6KA5 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling (By similarity). Phosphorylation at Tyr-705 by PTK6, isoform M2 of PKM (PKM2) or FER leads to an increase of its transcriptional activity (By similarity). Acetylated on lysine residues by CREBBP. Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated. Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated. (Microbial infection) Phosphorylated on Tyr-705 in the presence of S.typhimurium SarA. Early embryonic lethality, day 6.5-7.5. Conditional, tissue specific mutants are variably viable and show diverse defects including obesity, diabetes, thermal dysregulation and infertility. Involved in the gp130-mediated signaling pathway. Belongs to the transcription factor STAT family. nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II repressing transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding temperature homeostasis eye photoreceptor cell differentiation DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm mitochondrion mitochondrial inner membrane cytosol plasma membrane regulation of transcription, DNA-templated transcription from RNA polymerase II promoter protein import into nucleus defense response acute-phase response inflammatory response signal transduction JAK-STAT cascade aging transcription factor binding cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation response to organic substance negative regulation of autophagy positive regulation of gene expression negative regulation of hydrogen peroxide biosynthetic process postsynaptic density response to organic cyclic compound phosphorylation cytokine-mediated signaling pathway stem cell population maintenance protein kinase binding protein phosphatase binding sexual reproduction positive regulation of cell migration intracellular receptor signaling pathway chromatin DNA binding CCR5 chemokine receptor binding response to estradiol cellular response to hormone stimulus leptin-mediated signaling pathway response to cytokine glucocorticoid receptor binding miRNA mediated inhibition of translation regulation of multicellular organism growth regulation of cell proliferation response to drug glucose homeostasis eating behavior mRNA transcription from RNA polymerase II promoter identical protein binding protein homodimerization activity negative regulation of apoptotic process response to peptide hormone sequence-specific DNA binding transcription regulatory region DNA binding cellular response to leptin stimulus response to leptin nuclear transcription factor complex positive regulation of interleukin-6 biosynthetic process response to ethanol positive regulation of erythrocyte differentiation positive regulation of Notch signaling pathway positive regulation of angiogenesis negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of mitochondrial membrane permeability protein dimerization activity astrocyte differentiation modulation of synaptic transmission positive regulation of NF-kappaB transcription factor activity regulation of cell cycle radial glial cell differentiation regulation of feeding behavior growth hormone receptor signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway negative regulation of cell death interleukin-6-mediated signaling pathway cellular response to cytokine stimulus cellular response to organic cyclic compound T-helper 17 cell lineage commitment RNA polymerase II transcription factor complex energy homeostasis glutamatergic synapse postsynapse to nucleus signaling pathway negative regulation of neuron death positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of metalloendopeptidase activity positive regulation of vascular endothelial cell proliferation positive regulation of gene silencing by miRNA negative regulation of stem cell differentiation positive regulation of ATP biosynthetic process negative regulation of neuron migration uc007lmq.1 uc007lmq.2 uc007lmq.3 uc007lmq.4 
ENSMUST00000092672.6 Semp2l2b ENSMUST00000092672.6 SUMO/sentrin specific peptidase 2-like 2B (from RefSeq NM_053264.2) 4930444G20Rik D3Z741 D3Z741_MOUSE ENSMUST00000092672.1 ENSMUST00000092672.2 ENSMUST00000092672.3 ENSMUST00000092672.4 ENSMUST00000092672.5 NM_053264 Semp2l2b uc011xbi.1 uc011xbi.2 uc011xbi.3 uc011xbi.4 Belongs to the peptidase C48 family. nucleus proteolysis cysteine-type peptidase activity protein desumoylation uc011xbi.1 uc011xbi.2 uc011xbi.3 uc011xbi.4 
ENSMUST00000092678.10 Bclaf1 ENSMUST00000092678.10 BCL2-associated transcription factor 1, transcript variant 3 (from RefSeq NM_001025393.1) Bclaf1 ENSMUST00000092678.1 ENSMUST00000092678.2 ENSMUST00000092678.3 ENSMUST00000092678.4 ENSMUST00000092678.5 ENSMUST00000092678.6 ENSMUST00000092678.7 ENSMUST00000092678.8 ENSMUST00000092678.9 F8WI22 F8WI22_MOUSE NM_001025393 uc007env.1 uc007env.2 Belongs to the BCLAF1/THRAP3 family. nucleus apoptotic process negative regulation of transcription, DNA-templated positive regulation of response to DNA damage stimulus uc007env.1 uc007env.2 
ENSMUST00000092680.5 4933406P04Rik ENSMUST00000092680.5 4933406P04Rik (from geneSymbol) AK016707 ENSMUST00000092680.1 ENSMUST00000092680.2 ENSMUST00000092680.3 ENSMUST00000092680.4 uc287pwo.1 uc287pwo.2 uc287pwo.3 uc287pwo.4 uc287pwo.1 uc287pwo.2 uc287pwo.3 uc287pwo.4 
ENSMUST00000092688.12 Nt5c3b ENSMUST00000092688.12 5'-nucleotidase, cytosolic IIIB, transcript variant 1 (from RefSeq NM_001102650.2) 5NT3B_MOUSE A2A4I2 A2A4I3 ENSMUST00000092688.1 ENSMUST00000092688.10 ENSMUST00000092688.11 ENSMUST00000092688.2 ENSMUST00000092688.3 ENSMUST00000092688.4 ENSMUST00000092688.5 ENSMUST00000092688.6 ENSMUST00000092688.7 ENSMUST00000092688.8 ENSMUST00000092688.9 NM_001102650 Nt5c3l Q3TLP3 Q3UFY7 Q8BHU9 Q91WE8 Q9D9F9 uc007llf.1 uc007llf.2 uc007llf.3 uc007llf.4 Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity). Reaction=H2O + N(7)-methyl-GMP = N(7)-methylguanosine + phosphate; Xref=Rhea:RHEA:37107, ChEBI:CHEBI:15377, ChEBI:CHEBI:20794, ChEBI:CHEBI:43474, ChEBI:CHEBI:58285; EC=3.1.3.91; Evidence=; Reaction=CMP + H2O = cytidine + phosphate; Xref=Rhea:RHEA:29367, ChEBI:CHEBI:15377, ChEBI:CHEBI:17562, ChEBI:CHEBI:43474, ChEBI:CHEBI:60377; EC=3.1.3.91; Evidence=; Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377, ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5; Evidence=; Monomer. Cytoplasm Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3UFY7-1; Sequence=Displayed; Name=2; IsoId=Q3UFY7-2; Sequence=VSP_032853, VSP_032854; Name=3; IsoId=Q3UFY7-3; Sequence=VSP_032851, VSP_032852; Name=4; IsoId=Q3UFY7-4; Sequence=VSP_046298; Belongs to the pyrimidine 5'-nucleotidase family. Sequence=AAH15307.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB24814.1; Type=Frameshift; Evidence=; Sequence=BAC38632.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE37053.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAM23034.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM23036.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding magnesium ion binding cytoplasm biological_process nucleotide metabolic process dephosphorylation hydrolase activity metal ion binding 5'-nucleotidase activity uc007llf.1 uc007llf.2 uc007llf.3 uc007llf.4 
ENSMUST00000092694.4 Krtap9-20 ENSMUST00000092694.4 predicted gene 11559 (from RefSeq NM_001177484.2) ENSMUST00000092694.1 ENSMUST00000092694.2 ENSMUST00000092694.3 Gm11559 NM_001177484 OTTMUSG00000002191 Q9D3H7 Q9D3H7_MOUSE uc011yeu.1 uc011yeu.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc011yeu.1 uc011yeu.2 
ENSMUST00000092695.5 Krtap4-25 ENSMUST00000092695.5 predicted gene 11563 (from RefSeq NM_001126320.2) B1AQ90 B1AQ90_MOUSE ENSMUST00000092695.1 ENSMUST00000092695.2 ENSMUST00000092695.3 ENSMUST00000092695.4 Gm11563 NM_001126320 uc011yer.1 uc011yer.2 uc011yer.3 molecular_function cellular_component intermediate filament biological_process keratin filament uc011yer.1 uc011yer.2 uc011yer.3 
ENSMUST00000092696.5 Speer4c2 ENSMUST00000092696.5 spermatogenesis associated glutamate (E)-rich protein 4C2 (from RefSeq NR_073011.1) 4930572O03Rik ENSMUST00000092696.1 ENSMUST00000092696.2 ENSMUST00000092696.3 ENSMUST00000092696.4 NR_073011 Q8C5Y0 Q8C5Y0_MOUSE uc029vgb.1 uc029vgb.2 uc029vgb.3 uc029vgb.4 molecular_function cellular_component biological_process uc029vgb.1 uc029vgb.2 uc029vgb.3 uc029vgb.4 
ENSMUST00000092699.3 Krtap3-2 ENSMUST00000092699.3 keratin associated protein 3-2 (from RefSeq NM_025720.3) ENSMUST00000092699.1 ENSMUST00000092699.2 KRA32_MOUSE Krtap3-2 Krtap3-3 NM_025720 Q9CPW1 Q9D638 uc007lja.1 uc007lja.2 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). Interacts with hair keratins. Belongs to the KRTAP type 3 family. molecular_function structural molecule activity cellular_component intermediate filament biological_process keratin filament uc007lja.1 uc007lja.2 
ENSMUST00000092700.5 Krtap3-3 ENSMUST00000092700.5 keratin associated protein 3-3 (from RefSeq NM_025524.2) ENSMUST00000092700.1 ENSMUST00000092700.2 ENSMUST00000092700.3 ENSMUST00000092700.4 KRA32_MOUSE Krtap3-2 Krtap3-3 NM_025524 Q9CPW1 Q9D638 uc007liz.1 uc007liz.2 uc007liz.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). Interacts with hair keratins. Belongs to the KRTAP type 3 family. molecular_function structural molecule activity cellular_component intermediate filament biological_process keratin filament uc007liz.1 uc007liz.2 uc007liz.3 
ENSMUST00000092706.13 Cdc6 ENSMUST00000092706.13 cell division cycle 6, transcript variant 3 (from RefSeq NM_001362735.1) CDC6_MOUSE ENSMUST00000092706.1 ENSMUST00000092706.10 ENSMUST00000092706.11 ENSMUST00000092706.12 ENSMUST00000092706.2 ENSMUST00000092706.3 ENSMUST00000092706.4 ENSMUST00000092706.5 ENSMUST00000092706.6 ENSMUST00000092706.7 ENSMUST00000092706.8 ENSMUST00000092706.9 NM_001362735 O89033 Q3TMD0 Q8C3S5 Q9CZT0 uc007lhu.1 uc007lhu.2 uc007lhu.3 Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Interacts with PCNA, ORC1, cyclin-CDK (By similarity). Interacts with HUWE1 (By similarity). Interacts with ANKRD17 (By similarity). Interacts with GRWD1; origin binding of GRWD1 is dependent on CDC6 (By similarity). Interacts with CDT1; are mutually dependent on one another for loading MCM complexes onto chromatin (By similarity). Interacts with TTC4 (By similarity). Interacts (via Cy motif) with CCNF; the interaction takes place during G2 and M phase (By similarity). Interacts with CDH1 (By similarity). Nucleus Cytoplasm Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells. Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex. Belongs to the CDC6/cdc18 family. Sequence=CAA08752.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAA11110.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding mitotic cell cycle spindle pole chromatin binding DNA replication origin binding ATP binding nucleus cytoplasm spindle DNA replication DNA replication initiation cell cycle kinase binding regulation of mitotic metaphase/anaphase transition positive regulation of cytokinesis mitotic DNA replication checkpoint positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of fibroblast proliferation spindle midzone cell division positive regulation of chromosome segregation uc007lhu.1 uc007lhu.2 uc007lhu.3 
ENSMUST00000092720.4 Zfp1007 ENSMUST00000092720.4 zinc finger protein 1007 (from RefSeq NM_001378588.1) 5430403G16Rik D3Z5L4 D3Z5L4_MOUSE ENSMUST00000092720.1 ENSMUST00000092720.2 ENSMUST00000092720.3 NM_001378588 Zfp1007 uc290ycd.1 uc290ycd.2 transcription regulatory region sequence-specific DNA binding nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290ycd.1 uc290ycd.2 
ENSMUST00000092768.7 Dlx3 ENSMUST00000092768.7 distal-less homeobox 3 (from RefSeq NM_010055.4) Dlx3 ENSMUST00000092768.1 ENSMUST00000092768.2 ENSMUST00000092768.3 ENSMUST00000092768.4 ENSMUST00000092768.5 ENSMUST00000092768.6 NM_010055 Q78ZZ8 Q78ZZ8_MOUSE uc007kzy.1 uc007kzy.2 uc007kzy.3 uc007kzy.4 uc007kzy.5 Nucleus Belongs to the distal-less homeobox family. DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc007kzy.1 uc007kzy.2 uc007kzy.3 uc007kzy.4 uc007kzy.5 
ENSMUST00000092788.4 Tmem100 ENSMUST00000092788.4 transmembrane protein 100 (from RefSeq NM_026433.2) ENSMUST00000092788.1 ENSMUST00000092788.2 ENSMUST00000092788.3 NM_026433 Q9CQG9 TM100_MOUSE uc007kwm.1 uc007kwm.2 uc007kwm.3 Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor- dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10 (PubMed:22783020). Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons (PubMed:25640077). Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex (PubMed:25640077). Interacts (via C-terminus) with TRPA1 and TRPV1 (PubMed:25640077). Interacts with TASOR (PubMed:31112734). Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Perikaryon Cytoplasm, perinuclear region Endoplasmic reticulum Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system (By similarity). Expressed in dorsal root ganglia. Expressed in neurons as well as nerve fiber bundles connecting ganglia and fibers innervating muscle layer of the gastric body, jejunum, and proximal colon. Expressed in arterial endothelial cells and neurons of the central nervous system and peripheral nervous system (at protein level). Expressed strongly in lung, weakly in brain, heart and muscle. Expressed in enteric neurons and vascular tissue in the muscularis propria of the gastrointestinal tract. Expressed in embryo at 8.5 dpc. Expressed in arterial endothelial cells of the pharyngeal arch artery and endocardium at 9.5 dpc, onward. Expressed in dorsal aorta, pharyngeal arch and primitive internal carotid arteries at 11.5 dpc. Expressed also in intersomitic, mesenchephalic, metencephalic and anterior choroidal arteries at 12.5 dpc. Expressed in the ventral neural tube of the embryo. Mice die at a mid- or late-gestational period. Show embryonic lethality due to impaired differentiation of arterial endothelium and defects of vascular morphogenesis (PubMed:22783020). Conditional knockout in endothelial cells show similar vascular defects to those observed in global null mice (PubMed:20848592, PubMed:22783020). Conditional knockout mice lacking Tmem100 in dorsal root ganglia (DRG) primary sensory neurons, exhibit normal mechanical sensitivity but reduced acute nocifensive behaviors induced by mustard oil, consistent with a reduction in inflammatory mechanical hyperalgesia and TRPA1- but not TRPV1-mediated pain (PubMed:25640077). angiogenesis vasculogenesis in utero embryonic development endocardial cushion development epithelial to mesenchymal transition involved in endocardial cushion formation protein binding cytoplasm endoplasmic reticulum plasma membrane Notch signaling pathway multicellular organism development membrane integral component of membrane cell differentiation BMP signaling pathway perikaryon protein kinase B signaling positive regulation of endothelial cell differentiation perinuclear region of cytoplasm regulation of calcium-mediated signaling regulation of sensory perception of pain arterial endothelial cell differentiation cellular response to BMP stimulus positive regulation of vasculogenesis uc007kwm.1 uc007kwm.2 uc007kwm.3 
ENSMUST00000092821.10 Bcas3 ENSMUST00000092821.10 BCAS3 microtubule associated cell migration factor, transcript variant 3 (from RefSeq NM_001166643.1) Bcas3 ENSMUST00000092821.1 ENSMUST00000092821.2 ENSMUST00000092821.3 ENSMUST00000092821.4 ENSMUST00000092821.5 ENSMUST00000092821.6 ENSMUST00000092821.7 ENSMUST00000092821.8 ENSMUST00000092821.9 NM_001166643 Q0VF62 Q0VF62_MOUSE uc007krs.1 uc007krs.2 uc007krs.3 uc007krs.4 uc007krs.1 uc007krs.2 uc007krs.3 uc007krs.4 
ENSMUST00000092836.6 Wfdc17 ENSMUST00000092836.6 WAP four-disulfide core domain 17 (from RefSeq NM_001081957.1) Amwap ENSMUST00000092836.1 ENSMUST00000092836.2 ENSMUST00000092836.3 ENSMUST00000092836.4 ENSMUST00000092836.5 Gm11428 NM_001081957 OTTMUSG00000000971 Q5SSJ1 Q5SSJ1_MOUSE Wfdc17 uc007kpq.1 uc007kpq.2 uc007kpq.3 serine-type endopeptidase inhibitor activity cellular_component extracellular region biological_process negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc007kpq.1 uc007kpq.2 uc007kpq.3 
ENSMUST00000092883.3 Gm10277 ENSMUST00000092883.3 Gm10277 (from geneSymbol) AY512957 ENSMUST00000092883.1 ENSMUST00000092883.2 Gm10277 Q6R5C6 Q6R5C6_MOUSE uc288akt.1 uc288akt.2 molecular_function cellular_component biological_process uc288akt.1 uc288akt.2 
ENSMUST00000092888.11 Fbp1 ENSMUST00000092888.11 fructose bisphosphatase 1 (from RefSeq NM_019395.3) ENSMUST00000092888.1 ENSMUST00000092888.10 ENSMUST00000092888.2 ENSMUST00000092888.3 ENSMUST00000092888.4 ENSMUST00000092888.5 ENSMUST00000092888.6 ENSMUST00000092888.7 ENSMUST00000092888.8 ENSMUST00000092888.9 F16P1_MOUSE Fbp Fbp3 NM_019395 P97323 Q3UEH1 Q9QXD6 uc007qxg.1 uc007qxg.2 uc007qxg.3 Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377, ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 3 Mg(2+) ions per subunit. ; Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. AMP acts as an allosteric inhibitor. AMP binding affects the turnover of bound substrate and not the affinity for substrate. Fructose 2,6-bisphosphate acts as a competitive inhibitor. Fructose 2,6-bisphosphate and AMP have synergistic effects (By similarity). Carbohydrate biosynthesis; gluconeogenesis. Homotetramer. Detected in pancreatic beta-cell lines MIN6 and beta-TC and in liver (at protein level). Preferentially expressed in liver, with lower levels detected in pancreatic islets and intestine, and very low levels in blood, muscle, brain and spleen. Up-regulated in pancreas by obesity and dietary fat intake and in diabetic animals. Belongs to the FBPase class 1 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding catalytic activity nucleus cytoplasm cytosol carbohydrate metabolic process sucrose biosynthetic process fructose metabolic process fructose 6-phosphate metabolic process gluconeogenesis regulation of gluconeogenesis metabolic process AMP binding dephosphorylation hydrolase activity phosphatase activity negative regulation of cell growth fructose 1,6-bisphosphate metabolic process cellular response to drug fructose 1,6-bisphosphate 1-phosphatase activity phosphoric ester hydrolase activity identical protein binding negative regulation of glycolytic process negative regulation of Ras protein signal transduction metal ion binding monosaccharide binding protein homotetramerization cellular response to magnesium ion uc007qxg.1 uc007qxg.2 uc007qxg.3 
ENSMUST00000092891.6 Cacng7 ENSMUST00000092891.6 calcium channel, voltage-dependent, gamma subunit 7, transcript variant 1 (from RefSeq NM_133189.5) CCG7_MOUSE ENSMUST00000092891.1 ENSMUST00000092891.2 ENSMUST00000092891.3 ENSMUST00000092891.4 ENSMUST00000092891.5 NM_133189 P62956 Q8VBX3 Q8WXS6 Q9BXT1 uc009euu.1 uc009euu.2 uc009euu.3 Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (By similarity). Shows specificity only for GRIA1 and GRIA2 (By similarity). Interacts with CACNA1C. Identified in a complex with the L- type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or CACNB2 (By similarity). Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs), such as GRIA1 and GRIA2 (By similarity). Cell membrane ; Multi-pass membrane protein Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. voltage-gated ion channel activity calcium channel regulator activity calcium channel activity cytoplasm early endosome plasma membrane ion transport calcium ion transport membrane integral component of membrane AMPA glutamate receptor complex regulation of ion transmembrane transport neuron projection neuronal cell body regulation of mRNA stability cerebellar mossy fiber calcium ion transmembrane transport glutamatergic synapse integral component of postsynaptic density membrane neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of dendrite extension L-type voltage-gated calcium channel complex regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc009euu.1 uc009euu.2 uc009euu.3 
ENSMUST00000092907.12 Rpa1 ENSMUST00000092907.12 replication protein A1, transcript variant 2 (from RefSeq NM_026653.2) ENSMUST00000092907.1 ENSMUST00000092907.10 ENSMUST00000092907.11 ENSMUST00000092907.2 ENSMUST00000092907.3 ENSMUST00000092907.4 ENSMUST00000092907.5 ENSMUST00000092907.6 ENSMUST00000092907.7 ENSMUST00000092907.8 ENSMUST00000092907.9 NM_026653 Q3TEJ8 Q8VEE4 RFA1_MOUSE uc007kdi.1 uc007kdi.2 uc007kdi.3 uc007kdi.4 As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Component of the canonical replication protein A complex (RPA), a heterotrimer composed of RPA1, RPA2 and RPA3 (By similarity). The DNA-binding activity may reside exclusively on the RPA1 subunit (By similarity). Interacts with PRPF19; the PRP19-CDC5L complex is recruited to the sites of DNA repair where it ubiquitinates the replication protein A complex (RPA) (By similarity). Interacts with RIPK1 (By similarity). Interacts with the polymerase alpha subunit POLA1/p180; this interaction stabilizes the replicative complex and reduces the misincorporation rate of DNA polymerase alpha by acting as a fidelity clamp (By similarity). Interacts with RAD51 and SENP6 to regulate DNA repair (By similarity). Interacts with HELB; this interaction promotes HELB recruitment to chromatin following DNA damage (By similarity). Interacts with PRIMPOL; leading to recruit PRIMPOL on chromatin and stimulate its DNA primase activity (By similarity). Interacts with XPA; the interaction is direct and associates XPA with the RPA complex (By similarity). Interacts with ETAA1; the interaction is direct and promotes ETAA1 recruitment at stalled replication forks (By similarity). Interacts with RPA1; this interaction associates HROB with the RPA complex (PubMed:31467087). Interacts (when poly-ADP- ribosylated) with HTATSF1 (By similarity). Nucleus Nucleus, PML body DNA damage-induced 'Lys-63'-linked polyubiquitination by PRPF19 mediates ATRIP recruitment to the RPA complex at sites of DNA damage and activation of ATR. Ubiquitinated by RFWD3 at stalled replication forks in response to DNA damage: ubiquitination by RFWD3 does not lead to degradation by the proteasome and promotes removal of the RPA complex from stalled replication forks, promoting homologous recombination. Sumoylated on lysine residues Lys-458 and Lys-586, with Lys-458 being the major site. Sumoylation promotes recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. Desumoylated by SENP6 (By similarity). Poly-ADP-ribosylated by PARP1; promoting recruitment of HTATSF1. Belongs to the replication factor A protein 1 family. telomere maintenance double-strand break repair via homologous recombination nuclear chromosome, telomeric region condensed chromosome condensed nuclear chromosome lateral element male germ cell nucleus in utero embryonic development nucleic acid binding DNA binding chromatin binding damaged DNA binding single-stranded DNA binding nucleus nucleoplasm DNA replication factor A complex DNA replication DNA-dependent DNA replication DNA unwinding involved in DNA replication DNA repair base-excision repair nucleotide-excision repair mismatch repair DNA recombination cellular response to DNA damage stimulus telomere maintenance via telomerase positive regulation of cell proliferation PML body hemopoiesis protein localization to chromosome single-stranded telomeric DNA binding sequence-specific DNA binding metal ion binding homeostasis of number of cells within a tissue chromosome organization meiotic cell cycle G-rich strand telomeric DNA binding uc007kdi.1 uc007kdi.2 uc007kdi.3 uc007kdi.4 
ENSMUST00000092915.12 Cluh ENSMUST00000092915.12 clustered mitochondria homolog, transcript variant 2 (from RefSeq NM_001368711.1) A0A0R4J140 A0A0R4J140_MOUSE Cluh ENSMUST00000092915.1 ENSMUST00000092915.10 ENSMUST00000092915.11 ENSMUST00000092915.2 ENSMUST00000092915.3 ENSMUST00000092915.4 ENSMUST00000092915.5 ENSMUST00000092915.6 ENSMUST00000092915.7 ENSMUST00000092915.8 ENSMUST00000092915.9 NM_001368711 uc007kca.1 uc007kca.2 uc007kca.3 mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear- encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. Cytoplasm Cytoplasmic granule Belongs to the CLU family. RNA binding mRNA binding cytoplasm mitochondrion organization intracellular distribution of mitochondria uc007kca.1 uc007kca.2 uc007kca.3 
ENSMUST00000092921.3 Or1e23 ENSMUST00000092921.3 olfactory receptor family 1 subfamily E member 23 (from RefSeq NM_146443.1) ENSMUST00000092921.1 ENSMUST00000092921.2 NM_146443 Olfr381 Olfr382 Or1e23 Q8VF79 Q8VF79_MOUSE uc007kaw.1 uc007kaw.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007kaw.1 uc007kaw.2 
ENSMUST00000092926.11 Spata22 ENSMUST00000092926.11 spermatogenesis associated 22 (from RefSeq NM_001045531.1) ENSMUST00000092926.1 ENSMUST00000092926.10 ENSMUST00000092926.2 ENSMUST00000092926.3 ENSMUST00000092926.4 ENSMUST00000092926.5 ENSMUST00000092926.6 ENSMUST00000092926.7 ENSMUST00000092926.8 ENSMUST00000092926.9 Gm882 NM_001045531 Q5SV06 Repro42 SPT22_MOUSE Spata22 uc007kan.1 uc007kan.2 Meiosis-specific protein required for homologous recombination in meiosis I. Component of a multiprotein complex with MEIOB and RPA2 (PubMed:24240703). Interacts with the complex BRME1:HSF2BP:BRCA2 (PubMed:32345962). Chromosome Note=Localizes on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on MEIOB. Specifically expressed in gonadal germ cells, when male and female germ cells progress through prophase of meiosis I. In testis, weakly present from 8 dpp, and readily detectable from 10 dpp, with expression sustained through adulthood. Present in all populations of spermatocytes (at protein level). Mice develop and grow normally but show infertility in both sexes. Gametogenesis is affected with germ cells that do not progress beyond early meiotic prophase, with subsequent germ cell loss in both males and females. meiotic DNA repair synthesis protein binding cellular_component chromosome synapsis gamete generation fertilization meiotic cell cycle regulation of meiotic cell cycle reproductive system development uc007kan.1 uc007kan.2 
ENSMUST00000092931.7 Gm4952 ENSMUST00000092931.7 predicted gene 4952, transcript variant 2 (from RefSeq NM_001167907.1) E9QNP7 ENSMUST00000092931.1 ENSMUST00000092931.2 ENSMUST00000092931.3 ENSMUST00000092931.4 ENSMUST00000092931.5 ENSMUST00000092931.6 GLYAL_MOUSE NM_001167907 Q5FW57 uc008gug.1 uc008gug.2 uc008gug.3 uc008gug.4 Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity). Reaction=an acyl-CoA + glycine = an N-acylglycine + CoA + H(+); Xref=Rhea:RHEA:19869, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57670, ChEBI:CHEBI:58342; EC=2.3.1.13; Mitochondrion Belongs to the glycine N-acyltransferase family. Sequence=AAH89619.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; molecular_function mitochondrion biological_process transferase activity transferase activity, transferring acyl groups glycine N-acyltransferase activity uc008gug.1 uc008gug.2 uc008gug.3 uc008gug.4 
ENSMUST00000092937.13 Camkk1 ENSMUST00000092937.13 calcium/calmodulin-dependent protein kinase kinase 1, alpha, transcript variant 1 (from RefSeq NM_018883.3) Camkk ENSMUST00000092937.1 ENSMUST00000092937.10 ENSMUST00000092937.11 ENSMUST00000092937.12 ENSMUST00000092937.2 ENSMUST00000092937.3 ENSMUST00000092937.4 ENSMUST00000092937.5 ENSMUST00000092937.6 ENSMUST00000092937.7 ENSMUST00000092937.8 ENSMUST00000092937.9 KKCC1_MOUSE NM_018883 Q8VBY2 Q9R054 uc007jzt.1 uc007jzt.2 uc007jzt.3 uc007jzt.4 Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2- antagonist of cell death. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17; Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Partially inhibited upon phosphorylation by PRCAKA/PKA (By similarity). May be regulated through phosphorylation by CAMK1 and CAMK4. Interacts with CAMK4 and calmodulin. Cytoplasm Nucleus Widely expressed. Differentially expressed in various brain regions. The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates. Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity). Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity calmodulin binding ATP binding nucleus nucleoplasm cytoplasm cytosol protein phosphorylation kinase activity phosphorylation transferase activity activation of protein kinase activity intracellular signal transduction positive regulation of protein kinase activity uc007jzt.1 uc007jzt.2 uc007jzt.3 uc007jzt.4 
ENSMUST00000092940.13 Spns3 ENSMUST00000092940.13 SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative) (from RefSeq NM_029932.3) B2RX04 ENSMUST00000092940.1 ENSMUST00000092940.10 ENSMUST00000092940.11 ENSMUST00000092940.12 ENSMUST00000092940.2 ENSMUST00000092940.3 ENSMUST00000092940.4 ENSMUST00000092940.5 ENSMUST00000092940.6 ENSMUST00000092940.7 ENSMUST00000092940.8 ENSMUST00000092940.9 NM_029932 Q3U0X5 Q8BYA9 Q9D232 SPNS3_MOUSE uc007jzb.1 uc007jzb.2 uc007jzb.3 Sphingolipid transporter. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D232-1; Sequence=Displayed; Name=2; IsoId=Q9D232-2; Sequence=VSP_028199; Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. integral component of plasma membrane lipid transport membrane integral component of membrane transmembrane transport uc007jzb.1 uc007jzb.2 uc007jzb.3 
ENSMUST00000092955.11 Ahnak ENSMUST00000092955.11 AHNAK nucleoprotein, transcript variant 4 (from RefSeq NM_001286518.2) Ahnak ENSMUST00000092955.1 ENSMUST00000092955.10 ENSMUST00000092955.2 ENSMUST00000092955.3 ENSMUST00000092955.4 ENSMUST00000092955.5 ENSMUST00000092955.6 ENSMUST00000092955.7 ENSMUST00000092955.8 ENSMUST00000092955.9 G5E8K8 G5E8K8_MOUSE NM_001286518 uc008gok.1 uc008gok.2 uc008gok.3 uc008gok.4 uc008gok.5 Nucleus protein binding cytoplasm cytosol plasma membrane cell-cell junction actin cytoskeleton T-tubule vesicle sarcolemma costamere regulation of RNA splicing cell-cell contact zone S100 protein binding extracellular exosome regulation of voltage-gated calcium channel activity membrane raft uc008gok.1 uc008gok.2 uc008gok.3 uc008gok.4 uc008gok.5 
ENSMUST00000092966.5 Dynlt1c ENSMUST00000092966.5 dynein light chain Tctex-type 1C, transcript variant 8 (from RefSeq NM_001414437.1) DYLT1_MOUSE Dynlt1 ENSMUST00000092966.1 ENSMUST00000092966.2 ENSMUST00000092966.3 ENSMUST00000092966.4 NM_001414437 P51807 Q5M8S6 Tctel1 Tctex-1 Tctex1 uc008ahi.1 uc008ahi.2 uc008ahi.3 uc008ahi.4 uc008ahi.5 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia (By similarity). May also be a accessory component of axonemal dynein. Plays an important role in male germ cell development and function. Candidate for involvement in male sterility. Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta- gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling. Involved in the regulation of mitotic spindle orientation. Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non- catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with RHO (By similarity). Interacts with DYNC1I1 and DYNC1I2. Interacts with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2. Interacts with GNB1; the interaction occurs in presence of guanine nucleotide- binding protein G(T) subunit gamma; the interaction diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the interactions occur in presence of guanine nucleotide-binding protein G(T) subunit gamma. Interacts with ACVR2B and ARHGEF2 (By similarity). Interacts with DNAI4 (PubMed:30060180). P51807; P39688: Fyn; NbExp=3; IntAct=EBI-642797, EBI-524514; P51807; O46385: SVIL; Xeno; NbExp=4; IntAct=EBI-642797, EBI-6995105; Golgi apparatus Cytoplasm Cytoplasm, cytoskeleton, spindle Note=Localizes to mitotic spindles. High level in testis (germ cell-specific). Expressed in sperm (at protein level). 200-fold lower in liver, brain, heart, spleen, and kidney. Levels in thymus and two embryonal carcinoma cell lines were several-fold higher than this low constitutive level. First abundantly expressed at the pachytene stage of meiosis and persists throughout spermatogenesis. Phosphorylated by BMPR2. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release (By similarity). Belongs to the dynein light chain Tctex-type family. establishment of mitotic spindle orientation photoreceptor inner segment motor activity protein binding cytoplasm Golgi apparatus spindle cytoskeleton cytoplasmic dynein complex microtubule cytoplasmic microtubule cell cycle nervous system development protein C-terminus binding regulation of G-protein coupled receptor protein signaling pathway positive regulation of neuron projection development lamellipodium dynein complex growth cone GTP-dependent protein binding G-protein beta-subunit binding identical protein binding neuronal cell body axonal growth cone cell body negative regulation of neurogenesis cell division negative regulation of ERK1 and ERK2 cascade secretory vesicle uc008ahi.1 uc008ahi.2 uc008ahi.3 uc008ahi.4 uc008ahi.5 
ENSMUST00000092973.6 Cntrob ENSMUST00000092973.6 centrobin, centrosomal BRCA2 interacting protein (from RefSeq NM_172560.3) B0QZN4 CNTRB_MOUSE ENSMUST00000092973.1 ENSMUST00000092973.2 ENSMUST00000092973.3 ENSMUST00000092973.4 ENSMUST00000092973.5 Lip8 NM_172560 Q5NCF3 Q8CB62 uc007jpp.1 uc007jpp.2 uc007jpp.3 Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis (By similarity). Interacts with LYST. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Centriole-associated, asymmetrically localizes to the daughter centriole. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CB62-1; Sequence=Displayed; Name=2; IsoId=Q8CB62-2; Sequence=VSP_016842; Sequence=AAH58512.1; Type=Erroneous initiation; Evidence=; cytoplasm centrosome centriole cytosol cytoskeleton cell cycle centriole replication protein domain specific binding centrosome separation cell division regulation of cilium assembly mitotic cytokinetic process uc007jpp.1 uc007jpp.2 uc007jpp.3 
ENSMUST00000092995.6 Myh7b ENSMUST00000092995.6 myosin, heavy chain 7B, cardiac muscle, beta (from RefSeq NM_001085378.2) A2AQP0 ENSMUST00000092995.1 ENSMUST00000092995.2 ENSMUST00000092995.3 ENSMUST00000092995.4 ENSMUST00000092995.5 MYH7B_MOUSE NM_001085378 uc008nla.1 uc008nla.2 uc008nla.3 uc008nla.4 This gene encodes a myosin heavy chain. The encoded protein forms a hexamer comprised of two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. [provided by RefSeq, Jun 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Involved in muscle contraction. Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Membrane ; Peripheral membrane protein The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7). nucleotide binding motor activity actin binding ATP binding membrane myosin complex myosin filament actin filament binding cardiac myofibril uc008nla.1 uc008nla.2 uc008nla.3 uc008nla.4 
ENSMUST00000093002.12 Arhgap44 ENSMUST00000093002.12 Rho GTPase activating protein 44, transcript variant 5 (from RefSeq NM_001408226.1) Arhgap44 ENSMUST00000093002.1 ENSMUST00000093002.10 ENSMUST00000093002.11 ENSMUST00000093002.2 ENSMUST00000093002.3 ENSMUST00000093002.4 ENSMUST00000093002.5 ENSMUST00000093002.6 ENSMUST00000093002.7 ENSMUST00000093002.8 ENSMUST00000093002.9 NM_001408226 Q5SSM3 Q5SSM4 Q5SSM6 Q5SSM7 Q7TNB9 Q8BW90 RHG44_MOUSE Rich2 uc287yzi.1 uc287yzi.2 GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:24352656, PubMed:26969129). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (PubMed:23739967, PubMed:24352656, PubMed:26969129). Limits the initiation of exploratory dendritic filopodia. Recruited to actin- patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (PubMed:23739967). Interacts with BST2 (via cytoplasmic domain).Interacts (probably via PDZ-binding motif) with SHANK3 (via PDZ domain); the interaction takes place in dendritic spines and promotes GRIA1 exocytosis. Cell projection, dendritic spine Recycling endosome Presynapse Cell projection, dendrite Note=In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites (PubMed:23739967). Located in convoluted dendritic plasma membrane sections enriched in polymerized actin and myosin (patches) along dendrites where often emerge filopodia (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5SSM3-1; Sequence=Displayed; Name=2; IsoId=Q5SSM3-2; Sequence=VSP_023740, VSP_023741; Name=3; IsoId=Q5SSM3-3; Sequence=VSP_023741; Name=4; IsoId=Q5SSM3-4; Sequence=VSP_023737, VSP_023738, VSP_023739; Specifically expressed in brain (at protein level) (PubMed:26969129). Detected in olfactory bulb, cortex, hippocampus, diencephalon and cerebellum (at protein level) (PubMed:26969129). Expressed in hippocampal neurons (at protein level). Rho-GAP domain is required to promote GRIA1 exocytosis from recycling endosomes. Rho-GAP and BAR domains are necessary for the control of long-term potentiation in hippocampal neurons (PubMed:23739967). In dendrites, BAR domain mediates the recruitment to patches where plasma membrane is deformed by acto-myosin mediated contractile forces (By similarity). Mutants display a selective and highly significant fear of novel objects and increased stereotypic behavior as well as impairment of motor learning (PubMed:26969129). They show a nicrease in multiple synapses in the hippocampus and cerebellum (PubMed:26969129). [Isoform 2]: Contains a PDZ-binding motif at positions 761-764. [Isoform 3]: Contains a PDZ-binding motif at positions 767-770. Sequence=BAC35316.1; Type=Frameshift; Evidence=; Sequence=CAI24614.1; Type=Erroneous gene model prediction; Evidence=; [Isoform 4]: Sequence=BAC35316.1; Type=Frameshift; Evidence=; GTPase activator activity phospholipid binding cytoplasm endosome signal transduction postsynaptic density cell junction dendrite leading edge membrane regulation of actin cytoskeleton organization negative regulation of Rac protein signal transduction cell projection regulation of GTPase activity dendritic spine positive regulation of GTPase activity synapse Rac GTPase binding presynaptic active zone negative regulation of filopodium assembly recycling endosome regulation of dendritic spine morphogenesis modification of dendritic spine neurotransmitter receptor transport, endosome to postsynaptic membrane glutamatergic synapse modification of postsynaptic structure uc287yzi.1 uc287yzi.2 
ENSMUST00000093019.6 Fam83g ENSMUST00000093019.6 family with sequence similarity 83, member G (from RefSeq NM_178618.3) ENSMUST00000093019.1 ENSMUST00000093019.2 ENSMUST00000093019.3 ENSMUST00000093019.4 ENSMUST00000093019.5 FA83G_MOUSE NM_178618 Q5SWY7 Q5U437 Q8C1B0 uc007jid.1 uc007jid.2 uc007jid.3 Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. Interacts with SMAD1 (via MH2 domain); in a SMAD4-independent manner. Cytoplasm, cytosol Nucleus Note=Detected predominantly in the cytosol. Upon BMP stimulation, a small portion localizes the nucleus. BMP signaling induces the phosphorylation by BMPR1A at Ser-609, Ser-613 and Ser-615. Phosphorylation at Ser-609 is necessary for the activation of SMAD4-independent BMP target genes such as NEDD9 and ASNS. Belongs to the FAM83 family. Sequence=BAC26012.1; Type=Frameshift; Evidence=; molecular_function nucleus cytoplasm cytosol BMP signaling pathway uc007jid.1 uc007jid.2 uc007jid.3 
ENSMUST00000093029.9 Slc47a2 ENSMUST00000093029.9 solute carrier family 47, member 2 (from RefSeq NM_001033542.2) B2RXN1 ENSMUST00000093029.1 ENSMUST00000093029.2 ENSMUST00000093029.3 ENSMUST00000093029.4 ENSMUST00000093029.5 ENSMUST00000093029.6 ENSMUST00000093029.7 ENSMUST00000093029.8 Mate2 NM_001033542 Q3V050 Q5SS46 S47A2_MOUSE uc007jhg.1 uc007jhg.2 Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:17715386). May mediate testosterone efflux from the Leydig cells in the testes (PubMed:17715386). Kinetic parameters: KM=0.710 mM for TEA ; Vmax=0.004 nmol/min/mg enzyme toward TEA ; pH dependence: Optimum pH is 8.5. Active from pH 6 to 8.5. ; Cell membrane ; Multi-pass membrane protein Expressed in testis; especially in testicular Leydig cells. Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. Human SLC47A2/MATE2 and rodent SLC47A2/MATE2 exhibit only low mutual sequence identity (38.1%) and different expression patterns. In fact, the counterparts of human SLC47A2/MATE2 have not been identified in rats and mice, and the counterpart of rodent SLC47A2/MATE2 has not been found in humans. The phylogenetic tree of mammalian MATE-type transporters clearly suggested that rodent SLC47A2/MATE2 would be classified into an new subgroup:SLC47A3/MATE3 family but not SLC47A2/MATE2 family. As the nomenclature and classification are confusing, PubMed:17715386 suggested to rename mouse and rat SLC47A2/MATE2 to SLC47A3/MATE3. Sequence=CAI25733.1; Type=Erroneous gene model prediction; Evidence=; cellular_component drug transmembrane transport antiporter activity membrane integral component of membrane xenobiotic transport xenobiotic transporter activity transmembrane transport uc007jhg.1 uc007jhg.2 
ENSMUST00000093033.6 Capn9 ENSMUST00000093033.6 calpain 9 (from RefSeq NM_023709.4) CAN9_MOUSE E9QNM7 ENSMUST00000093033.1 ENSMUST00000093033.2 ENSMUST00000093033.3 ENSMUST00000093033.4 ENSMUST00000093033.5 NM_023709 Ncl4 O35919 Q9D805 uc009nxf.1 uc009nxf.2 uc009nxf.3 Calcium-regulated non-lysosomal thiol-protease. Cytoplasm Predominantly expressed in stomach and small intestine, although low levels of expression in other organs. Belongs to the peptidase C2 family. calcium-dependent cysteine-type endopeptidase activity calcium ion binding cytoplasm proteolysis hydrolase activity sarcomere organization metal ion binding uc009nxf.1 uc009nxf.2 uc009nxf.3 
ENSMUST00000093040.13 Rab4b ENSMUST00000093040.13 RAB4B, member RAS oncogene family (from RefSeq NM_029391.2) ENSMUST00000093040.1 ENSMUST00000093040.10 ENSMUST00000093040.11 ENSMUST00000093040.12 ENSMUST00000093040.2 ENSMUST00000093040.3 ENSMUST00000093040.4 ENSMUST00000093040.5 ENSMUST00000093040.6 ENSMUST00000093040.7 ENSMUST00000093040.8 ENSMUST00000093040.9 NM_029391 Q91ZR1 RAB4B_MOUSE Rab4 uc009fvc.1 uc009fvc.2 uc009fvc.3 Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:14697203). Protein transport (By similarity). Probably involved in vesicular traffic (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (PubMed:14697203). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Cell membrane ; Lipid-anchor ; Cytoplasmic side Serotonylation of Gln-67 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity GTP binding mitochondrion endosome plasma membrane intracellular protein transport protein transport membrane regulation of endocytosis Rab protein signal transduction insulin-responsive compartment glucose import perinuclear region of cytoplasm recycling endosome anchored component of synaptic vesicle membrane uc009fvc.1 uc009fvc.2 uc009fvc.3 
ENSMUST00000093043.7 Gas8 ENSMUST00000093043.7 growth arrest specific 8, transcript variant 4 (from RefSeq NR_189740.1) DRC4_MOUSE Drc4 ENSMUST00000093043.1 ENSMUST00000093043.2 ENSMUST00000093043.3 ENSMUST00000093043.4 ENSMUST00000093043.5 ENSMUST00000093043.6 Gas11 NR_189740 Q60779 Q99L71 uc009nwk.1 uc009nwk.2 uc009nwk.3 Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (PubMed:17366626, PubMed:21659505, PubMed:27472056). May play a role in the spermatozoa motility (PubMed:11751847). Component of the nexin-dynein regulatory complex (N-DRC) (By similarity). Interacts with microtubules (PubMed:17366626). Interacts with SMO (PubMed:21659505). Interacts (via coiled-coil domains) with RAB3B (in GTP-bound form) (PubMed:18396146). Interacts with DRC1 (By similarity). Interacts with DRC7 (PubMed:31961863). Cytoplasm toplasm, cytoskeleton Cell projection, cilium, flagellum Cytoplasm, cytoskeleton, cilium axoneme toplasm, cytoskeleton, cilium basal body lgi apparatus Cell projection, cilium Cytoplasm, cytoskeleton, flagellum axoneme Note=Associates with microtubules (PubMed:17366626). Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa (PubMed:11751847). Highly expressed in adult testes and lung. Weakly or not expressed in other tested tissues. Weakly or not expressed in neonates and young adolescents. Then, it is strongly expressed postmeiotically. Accumulates in gametocytes as they approach the lumen of seminiferous tubules and thereafter. Expressed during serum starvation or contact inhibition of cells grown in murine fibroblasts. Mice show primary ciliary dyskinesia (PCD) like symptoms including situs inversus and hydrocephalus. Hydrocephalus starts at postnatal day 5 (P5) and becomes more pronounced as the mice mature, eventually leading to mortality between P14-P21. Development of hydrocephalus is associated with severe impairment of cilia motility on ependymal cells lining the ventricles of the brain. Belongs to the DRC4 family. Sequence=AAA85258.1; Type=Frameshift; Evidence=; epithelial cilium movement molecular_function protein binding extracellular region cytoplasm Golgi apparatus cytoskeleton microtubule cilium axoneme determination of left/right symmetry brain development microtubule binding microtubule cytoskeleton Rab GTPase binding flagellated sperm motility motile cilium cellular protein localization axoneme assembly ciliary basal body sperm flagellum cell projection positive regulation of smoothened signaling pathway cell motility cilium movement involved in cell motility 9+2 motile cilium positive regulation of protein localization to cilium regulation of microtubule binding uc009nwk.1 uc009nwk.2 uc009nwk.3 
ENSMUST00000093059.3 Pabpn1l ENSMUST00000093059.3 poly(A)binding protein nuclear 1-like (from RefSeq NM_001007462.1) B9EJ43 ENSMUST00000093059.1 ENSMUST00000093059.2 EPAB2_MOUSE Epabp2 Gm1108 NM_001007462 Pabpnl1 Q5XFR0 uc009ntk.1 uc009ntk.2 uc009ntk.3 Binds the poly(A) tail of mRNA. Cytoplasm Expression is restricted to oogenesis, early embryogenesis and the adult ovary. Sequence=C85607; Type=Frameshift; Evidence=; Sequence=C85607; Type=Miscellaneous discrepancy; Note=Deletions and sequence errors.; Evidence=; Sequence=C85611; Type=Frameshift; Evidence=; Sequence=C85611; Type=Miscellaneous discrepancy; Note=Deletions and sequence errors.; Evidence=; Sequence=C86787; Type=Frameshift; Evidence=; Sequence=C86787; Type=Miscellaneous discrepancy; Note=Deletions and sequence errors.; Evidence=; nucleic acid binding RNA binding cytoplasm poly(A) binding biological_process uc009ntk.1 uc009ntk.2 uc009ntk.3 
ENSMUST00000093061.7 Trim11 ENSMUST00000093061.7 tripartite motif-containing 11, transcript variant 2 (from RefSeq NM_053168.2) A2A868 A2AB84 ENSMUST00000093061.1 ENSMUST00000093061.2 ENSMUST00000093061.3 ENSMUST00000093061.4 ENSMUST00000093061.5 ENSMUST00000093061.6 NM_053168 Q3TCL5 Q8VDX5 Q99PQ2 TRI11_MOUSE uc007jda.1 uc007jda.2 uc007jda.3 uc007jda.4 E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX (PubMed:18628401). Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis (PubMed:18628401). May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences (PubMed:18628401). May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (PubMed:12670303). Mediates MED15 ubiquitination leading to proteasomal degradation (By similarity). May contribute to the innate restriction of retroviruses (PubMed:18248090). Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression (PubMed:18248090). Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain (PubMed:18248090). May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle (PubMed:18248090). Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2 (By similarity). Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Binds cytoplasmic tail of integrin alpha-1 (By similarity). Interacts with the HN peptide (PubMed:12670303). Interacts with PHOX2B (PubMed:18275850). Interacts (when autoubiquitinated) with SQSTM1/p62; promoting AIM2 recruitment to autophagosomes (By similarity). Interacts with AIM2; promoting its autophagy-dependent degradation (By similarity). Cytoplasm Nucleus Note=In the nucleus, colocalizes with PAX6. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99PQ2-1; Sequence=Displayed; Name=2; IsoId=Q99PQ2-2; Sequence=VSP_012059; Expressed in embryonic central nervous system (CNS), kidney, thymus and gut. By PAX6. The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6. They are also involved in MED15- binding. The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins. Autoubiquitinated upon DNA stimulation; autoubiquitination promotes interaction with SQSTM1/p62 and recruitment of AIM2 to autophagosomes. Belongs to the TRIM/RBCC family. ubiquitin-protein transferase activity protein binding nucleus cytoplasm cytosol transcription factor binding zinc ion binding protein ubiquitination transferase activity protein domain specific binding negative regulation of viral transcription innate immune response negative regulation of transcription, DNA-templated negative regulation of viral entry into host cell positive regulation of viral entry into host cell metal ion binding negative regulation of neurogenesis defense response to virus ubiquitin protein ligase activity negative regulation of viral release from host cell uc007jda.1 uc007jda.2 uc007jda.3 uc007jda.4 
ENSMUST00000093099.13 Taf1c ENSMUST00000093099.13 TATA-box binding protein associated factor, RNA polymerase I, C, transcript variant 1 (from RefSeq NM_021441.3) ENSMUST00000093099.1 ENSMUST00000093099.10 ENSMUST00000093099.11 ENSMUST00000093099.12 ENSMUST00000093099.2 ENSMUST00000093099.3 ENSMUST00000093099.4 ENSMUST00000093099.5 ENSMUST00000093099.6 ENSMUST00000093099.7 ENSMUST00000093099.8 ENSMUST00000093099.9 NM_021441 P97359 Q3U3B6 Q6PDZ2 Q8BN54 TAF1C_MOUSE uc009npy.1 uc009npy.2 uc009npy.3 Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3 (By similarity). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription (By similarity). Nucleus RNA polymerase I transcription factor complex RNA polymerase I CORE element sequence-specific DNA binding RNA polymerase I transcriptional preinitiation complex assembly fibrillar center DNA binding protein binding nucleus nucleoplasm nucleolus transcription from RNA polymerase I promoter uc009npy.1 uc009npy.2 uc009npy.3 
ENSMUST00000093100.3 Dnaaf1 ENSMUST00000093100.3 dynein, axonemal assembly factor 1 (from RefSeq NM_026648.4) DAAF1_MOUSE ENSMUST00000093100.1 ENSMUST00000093100.2 Lrrc50 NM_026648 Q9CVS9 Q9D2H9 uc009npw.1 uc009npw.2 Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity). Cell projection, cilium Belongs to the DNAAF1 family. heart looping cilium movement regulation of cilium beat frequency cytosol plasma membrane cilium axoneme nuclear speck lung development determination of pancreatic left/right asymmetry outer dynein arm assembly inner dynein arm assembly cell projection motile cilium assembly cilium assembly left/right pattern formation axonemal dynein complex assembly dynein complex binding determination of digestive tract left/right asymmetry determination of liver left/right asymmetry uc009npw.1 uc009npw.2 
ENSMUST00000093110.12 Medag ENSMUST00000093110.12 mesenteric estrogen dependent adipogenesis, transcript variant 3 (from RefSeq NR_151595.1) Awms3 ENSMUST00000093110.1 ENSMUST00000093110.10 ENSMUST00000093110.11 ENSMUST00000093110.2 ENSMUST00000093110.3 ENSMUST00000093110.4 ENSMUST00000093110.5 ENSMUST00000093110.6 ENSMUST00000093110.7 ENSMUST00000093110.8 ENSMUST00000093110.9 MEDAG_MOUSE Meda4 NR_151595 Q14BA6 Q8BFY2 Q8C9B3 Q8CHK6 Q8R0K5 Q9CU47 uc009apt.1 uc009apt.2 uc009apt.3 Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14BA6-1; Sequence=Displayed; Name=2; IsoId=Q14BA6-2; Sequence=VSP_022716; Highly expressed in white adipose tissue compared with other organs with higher expression in mature adipocyte fraction. Significant expression is also detected in the heart, brain, and pancreas. Down-regulated by estrogen treatment. Sequence=BAC31291.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC53804.1; Type=Frameshift; Evidence=; Sequence=BAE23601.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE37424.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cytoplasm positive regulation of fat cell differentiation uc009apt.1 uc009apt.2 uc009apt.3 
ENSMUST00000093113.5 Adamts18 ENSMUST00000093113.5 ADAM metallopeptidase with thrombospondin type 1 motif 18, transcript variant 1 (from RefSeq NM_172466.4) ATS18_MOUSE E9QNK0 ENSMUST00000093113.1 ENSMUST00000093113.2 ENSMUST00000093113.3 ENSMUST00000093113.4 NM_172466 Q4VC17 Q8BZD1 uc009nnr.1 uc009nnr.2 uc009nnr.3 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2- G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3- glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). eye development molecular_function metalloendopeptidase activity extracellular region proteolysis peptidase activity metallopeptidase activity hydrolase activity metal ion binding negative regulation of platelet aggregation uc009nnr.1 uc009nnr.2 uc009nnr.3 
ENSMUST00000093126.11 BC107364 ENSMUST00000093126.11 BC107364 (from geneSymbol) BC107365 ENSMUST00000093126.1 ENSMUST00000093126.10 ENSMUST00000093126.2 ENSMUST00000093126.3 ENSMUST00000093126.4 ENSMUST00000093126.5 ENSMUST00000093126.6 ENSMUST00000093126.7 ENSMUST00000093126.8 ENSMUST00000093126.9 uc008qmz.1 uc008qmz.2 uc008qmz.3 uc008qmz.1 uc008qmz.2 uc008qmz.3 
ENSMUST00000093132.13 Clk4 ENSMUST00000093132.13 CDC like kinase 4, transcript variant 1 (from RefSeq NM_007714.6) Clk4 ENSMUST00000093132.1 ENSMUST00000093132.10 ENSMUST00000093132.11 ENSMUST00000093132.12 ENSMUST00000093132.2 ENSMUST00000093132.3 ENSMUST00000093132.4 ENSMUST00000093132.5 ENSMUST00000093132.6 ENSMUST00000093132.7 ENSMUST00000093132.8 ENSMUST00000093132.9 NM_007714 Q4FJV9 Q4FJV9_MOUSE uc007itr.1 uc007itr.2 uc007itr.3 uc007itr.4 Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation kinase activity phosphorylation regulation of RNA splicing uc007itr.1 uc007itr.2 uc007itr.3 uc007itr.4 
ENSMUST00000093138.13 Tbc1d9b ENSMUST00000093138.13 TBC1 domain family, member 9B, transcript variant 3 (from RefSeq NM_029745.2) ENSMUST00000093138.1 ENSMUST00000093138.10 ENSMUST00000093138.11 ENSMUST00000093138.12 ENSMUST00000093138.2 ENSMUST00000093138.3 ENSMUST00000093138.4 ENSMUST00000093138.5 ENSMUST00000093138.6 ENSMUST00000093138.7 ENSMUST00000093138.8 ENSMUST00000093138.9 Kiaa0676 NM_029745 Q3UGF5 Q5SVR0 Q6A019 Q6P1G9 Q6PDP2 Q80ZU6 Q8C7K9 Q8CBR7 Q8CCW2 Q9CSQ2 TBC9B_MOUSE uc007irq.1 uc007irq.2 uc007irq.3 May act as a GTPase-activating protein for Rab family protein(s). Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SVR0-1; Sequence=Displayed; Name=2; IsoId=Q5SVR0-2; Sequence=VSP_025700; The arginine and glutamine fingers are critical for the GTPase- activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site. Sequence=BAC27640.1; Type=Erroneous initiation; Evidence=; Sequence=BAD32277.1; Type=Erroneous initiation; Evidence=; GTPase activator activity calcium ion binding cell intracellular protein transport membrane integral component of membrane Rab GTPase binding activation of GTPase activity uc007irq.1 uc007irq.2 uc007irq.3 
ENSMUST00000093142.12 Rasgef1c ENSMUST00000093142.12 RasGEF domain family, member 1C, transcript variant 2 (from RefSeq NM_029004.1) ENSMUST00000093142.1 ENSMUST00000093142.10 ENSMUST00000093142.11 ENSMUST00000093142.2 ENSMUST00000093142.3 ENSMUST00000093142.4 ENSMUST00000093142.5 ENSMUST00000093142.6 ENSMUST00000093142.7 ENSMUST00000093142.8 ENSMUST00000093142.9 NM_029004 Q8BYJ7 Q9D300 RGF1C_MOUSE uc007irj.1 uc007irj.2 uc007irj.3 Guanine nucleotide exchange factor (GEF). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D300-1; Sequence=Displayed; Name=2; IsoId=Q9D300-2; Sequence=VSP_027317; Sequence=CAI23944.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAI24373.1; Type=Erroneous gene model prediction; Evidence=; guanyl-nucleotide exchange factor activity small GTPase mediated signal transduction uc007irj.1 uc007irj.2 uc007irj.3 
ENSMUST00000093162.4 Atxn1l ENSMUST00000093162.4 ataxin 1-like, transcript variant 2 (from RefSeq NM_001368350.1) ATX1L_MOUSE Boat ENSMUST00000093162.1 ENSMUST00000093162.2 ENSMUST00000093162.3 NM_001368350 P0C7T6 uc009njh.1 uc009njh.2 Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ- mediated repression (By similarity). Can suppress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1) (PubMed:16121196). In concert with CIC and ATXN1, involved in brain development (PubMed:28288114). Homodimer. Interacts (via AXH domain) with NCOR2 (By similarity). Interacts with ATXN1 and CIC. Directly interacts with RBPJ; this interaction is disrupted in the presence of Notch intracellular domain. Competes with ATXN1 for RBPJ-binding (By similarity). Found in a complex with CIC and ATXN1 (PubMed:28288114). Nucleus Cell projection, dendrite Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells. Expressed in the cortex and hypothalamus (at protein level). Expressed in neuronal cells. Highly expressed in Purkinje cells of cerebellum. Mice with conditional knockouts of either ATXN1- ATXN1L or CIC in the developing forebrain exhibit intellectual disability, hyperactivity, social-behavioral deficits and reduced thickness of upper cortical layers. Its overexpression suppresses the ataxia caused by polyglutamine-expanded Atxn1. Competes with mutant Atxn1 and wild-type Atxn1 for association with CIC. Decreased association of mutant Atxn1 into its CIC-containing complexes decreases the levels of mutant Atxn1- containing CIC complexes, suppressing pathology, while promoting aggregation and thus increasing nuclear inclusions. Belongs to the ATXN1 family. negative regulation of transcription from RNA polymerase II promoter DNA binding RNA binding protein binding nucleus nucleoplasm nucleolus regulation of transcription, DNA-templated brain development learning memory extracellular matrix organization dendrite social behavior cell projection lung alveolus development anatomical structure development positive regulation of hematopoietic stem cell proliferation uc009njh.1 uc009njh.2 
ENSMUST00000093165.12 Cyfip2 ENSMUST00000093165.12 cytoplasmic FMR1 interacting protein 2, transcript variant 2 (from RefSeq NM_001252459.1) CYFP2_MOUSE Cyfip2 ENSMUST00000093165.1 ENSMUST00000093165.10 ENSMUST00000093165.11 ENSMUST00000093165.2 ENSMUST00000093165.3 ENSMUST00000093165.4 ENSMUST00000093165.5 ENSMUST00000093165.6 ENSMUST00000093165.7 ENSMUST00000093165.8 ENSMUST00000093165.9 Kiaa1168 NM_001252459 Pir121 Q3UH21 Q3UHS8 Q5SQX6 Q8BSW0 Q8CHA9 Q924D3 Q9R181 uc007iod.1 uc007iod.2 uc007iod.3 uc007iod.4 Part of the WAVE1 complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). Involved in T-cell adhesion and p53-dependent induction of apoptosis (By similarity). Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705). Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Interacts with FMR1, FXR1 and FXR2 (PubMed:11438699). Interacts with FMR1; the interaction occurs in a RNA-dependent manner (By similarity). Interacts with RAC1 (activated form) which causes the complex to dissociate, releasing activated WASF1 (By similarity). The complex can also be activated by NCK1 (By similarity). Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex (PubMed:24153177). Interacts with TMEM108 (via N-terminus); the interaction associates TMEM108 with the WAVE1 complex (PubMed:27605705). Q5SQX6; Q4ACU6: Shank3; NbExp=3; IntAct=EBI-773783, EBI-771450; Cytoplasm Nucleus Cytoplasm, perinuclear region Synapse, synaptosome Note=Highly expressed in the perinuclear region and enriched in synaptosomes (PubMed:11438699). Expressed in hippocampus (at protein level). Modified_positions=320 ; Note=Partially edited. Editing appears to be brain-specific. ; Belongs to the CYFIP family. Sequence=BAC41472.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cell morphogenesis protein binding nucleus cytoplasm apoptotic process cell adhesion axon guidance cell projection assembly cell junction neuron projection development neuron projection synapse positive regulation of proteolysis perinuclear region of cytoplasm positive regulation of neurotrophin TRK receptor signaling pathway activation of cysteine-type endopeptidase activity dendrite extension cell-cell adhesion RNA 7-methylguanosine cap binding SCAR complex uc007iod.1 uc007iod.2 uc007iod.3 uc007iod.4 
ENSMUST00000093169.3 Sft2d1rt ENSMUST00000093169.3 May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. (from UniProt Q5SSN7) A1L3Q4 BC130232 ENSMUST00000093169.1 ENSMUST00000093169.2 Q5SSN7 SFT2A_MOUSE Sft2d1 uc287xpi.1 uc287xpi.2 May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Membrane ; Multi-pass membrane protein Belongs to the SFT2 family. molecular_function protein transport membrane integral component of membrane vesicle-mediated transport uc287xpi.1 uc287xpi.2 
ENSMUST00000093183.5 Smco1 ENSMUST00000093183.5 single-pass membrane protein with coiled-coil domains 1 (from RefSeq NM_183283.3) A3KMI2 E9PUG1 ENSMUST00000093183.1 ENSMUST00000093183.2 ENSMUST00000093183.3 ENSMUST00000093183.4 NM_183283 Q8CEZ1 SMCO1_MOUSE uc007yyn.1 uc007yyn.2 uc007yyn.3 uc007yyn.4 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CEZ1-1; Sequence=Displayed; Name=2; IsoId=Q8CEZ1-2; Sequence=VSP_046481; Sequence=AAI31955.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc007yyn.1 uc007yyn.2 uc007yyn.3 uc007yyn.4 
ENSMUST00000093191.3 Spdl1 ENSMUST00000093191.3 spindle apparatus coiled-coil protein 1 (from RefSeq NM_027411.2) Ccdc99 ENSMUST00000093191.1 ENSMUST00000093191.2 NM_027411 Q5DY45 Q923A2 SPDLY_MOUSE uc007ilc.1 uc007ilc.2 uc007ilc.3 uc007ilc.4 Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non- processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Plays a role in cell migration (By similarity). Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect. Interacts with dynein intermediate chain and dynactin (DCTN1) (By similarity). Interacts with the catalytically active form of USP45 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Chromosome, centromere, kinetochore Nucleus. Cytoplasm, cytoskeleton, spindle pole te=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex. Monoubiquitinated with'Lys-48' linkage (By similarity). Deubiquitinated by USP45 (By similarity). Belongs to the Spindly family. establishment of mitotic spindle orientation chromosome, centromeric region kinetochore condensed chromosome kinetochore spindle pole condensed chromosome outer kinetochore nucleus chromosome cytoplasm microtubule organizing center cytoskeleton cell cycle mitotic metaphase plate congression mitotic spindle assembly checkpoint enzyme binding protein localization to kinetochore kinetochore binding cell division uc007ilc.1 uc007ilc.2 uc007ilc.3 uc007ilc.4 
ENSMUST00000093193.12 Dock2 ENSMUST00000093193.12 dedicator of cyto-kinesis 2 (from RefSeq NM_033374.3) DOCK2_MOUSE ENSMUST00000093193.1 ENSMUST00000093193.10 ENSMUST00000093193.11 ENSMUST00000093193.2 ENSMUST00000093193.3 ENSMUST00000093193.4 ENSMUST00000093193.5 ENSMUST00000093193.6 ENSMUST00000093193.7 ENSMUST00000093193.8 ENSMUST00000093193.9 NM_033374 Q5SRI4 Q8C3J5 Q99M79 uc033fuj.1 uc033fuj.2 uc033fuj.3 uc033fuj.4 Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. Homodimer (Probable). Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z (By similarity). Endomembrane system ; Peripheral membrane protein Cytoplasm, cytoskeleton Note=Colocalizes with F-actin. Specifically expressed in hematopoietic cells. The DOCKER domain probably mediates the GEF activity. Belongs to the DOCK family. membrane raft polarization establishment of T cell polarity immunological synapse formation myeloid dendritic cell activation involved in immune response guanyl-nucleotide exchange factor activity GTPase activator activity cytoplasm cytoskeleton chemotaxis cytoskeleton organization small GTPase mediated signal transduction endomembrane system membrane actin cytoskeleton organization Rac guanyl-nucleotide exchange factor activity positive regulation of Rac protein signal transduction T cell proliferation T cell activation T cell receptor binding positive regulation of GTPase activity macropinocytosis positive thymic T cell selection negative thymic T cell selection alpha-beta T cell activation alpha-beta T cell proliferation positive regulation of phagocytosis uc033fuj.1 uc033fuj.2 uc033fuj.3 uc033fuj.4 
ENSMUST00000093195.7 Pard6a ENSMUST00000093195.7 par-6 family cell polarity regulator alpha, transcript variant 1 (from RefSeq NM_019695.3) ENSMUST00000093195.1 ENSMUST00000093195.2 ENSMUST00000093195.3 ENSMUST00000093195.4 ENSMUST00000093195.5 ENSMUST00000093195.6 NM_019695 PAR6A_MOUSE Par6a Q5RL03 Q6P8R2 Q9Z101 uc009ndv.1 uc009ndv.2 uc009ndv.3 uc009ndv.4 Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:15761148). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (By similarity). Interacts with ECT2 ('Thr-359' phosphorylated form) and PRKCI. Interacts with PALS1 and CRB3 (By similarity). Interacts with PARD3. Interacts with GTP-bound forms of CDC42, RHOQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with MAP2K5. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with DCTN1 and PCM1 (By similarity). Q9Z101; O14641: DVL2; Xeno; NbExp=6; IntAct=EBI-81732, EBI-740850; Cytoplasm Cell membrane Cell junction, tight junction Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 at epithelial tight junctions. Recruited to the centrosome by a microtubule and dynein- dynactin-dependent mechanism. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Z101-1; Sequence=Displayed; Name=2; IsoId=Q9Z101-2; Sequence=VSP_015462; Name=3; IsoId=Q9Z101-3; Sequence=VSP_015463; The PB1 domain mediates interactions with MAP2K5. The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases. The PDZ domain mediates the interaction with CRB3. Phosphorylated by the TGF-beta receptor. Belongs to the PAR6 family. Sequence=AAD15928.1; Type=Frameshift; Evidence=; negative regulation of protein phosphorylation protein kinase C binding protein binding nucleus cytoplasm centrosome microtubule organizing center cytoskeleton plasma membrane bicellular tight junction cell cortex cell cycle centrosome cycle establishment or maintenance of cell polarity membrane apical plasma membrane Rho GTPase binding establishment of cell polarity cell junction GTP-dependent protein binding macromolecular complex centriolar satellite neuronal cell body axonal growth cone cell-cell junction maintenance positive regulation of protein secretion cell division regulation of cellular localization positive regulation of protein localization to centrosome uc009ndv.1 uc009ndv.2 uc009ndv.3 uc009ndv.4 
ENSMUST00000093207.4 Hba-a2 ENSMUST00000093207.4 hemoglobin alpha, adult chain 2 (from RefSeq NM_001083955.1) ENSMUST00000093207.1 ENSMUST00000093207.2 ENSMUST00000093207.3 Glnc1 Hba-a1 Hba-a2 NM_001083955 Q91VB8 Q91VB8_MOUSE haemaglobin alpha 1 haemaglobin alpha 2 uc007ijm.1 uc007ijm.2 uc007ijm.3 uc007ijm.4 Involved in oxygen transport from the lung to the various peripheral tissues. Belongs to the globin family. in utero embryonic development oxygen transporter activity iron ion binding extracellular space hemoglobin complex response to bacterium oxygen transport oxygen binding heme binding cytosolic small ribosomal subunit haptoglobin-hemoglobin complex organic acid binding metal ion binding erythrocyte development cellular oxidant detoxification peroxidase activity haptoglobin binding uc007ijm.1 uc007ijm.2 uc007ijm.3 uc007ijm.4 
ENSMUST00000093209.4 Hba-a1 ENSMUST00000093209.4 hemoglobin alpha, adult chain 1 (from RefSeq NM_008218.2) ENSMUST00000093209.1 ENSMUST00000093209.2 ENSMUST00000093209.3 Glnc1 Hba-a1 Hba-a2 NM_008218 Q91VB8 Q91VB8_MOUSE haemaglobin alpha 1 haemaglobin alpha 2 uc007ijk.1 uc007ijk.2 uc007ijk.3 uc007ijk.4 Involved in oxygen transport from the lung to the various peripheral tissues. Belongs to the globin family. in utero embryonic development oxygen transporter activity iron ion binding extracellular space hemoglobin complex response to bacterium oxygen transport oxygen binding heme binding cytosolic small ribosomal subunit haptoglobin-hemoglobin complex organic acid binding metal ion binding erythrocyte development cellular oxidant detoxification peroxidase activity haptoglobin binding uc007ijk.1 uc007ijk.2 uc007ijk.3 uc007ijk.4 
ENSMUST00000093221.13 Ces3b ENSMUST00000093221.13 carboxylesterase 3B, transcript variant 1 (from RefSeq NM_144511.2) ENSMUST00000093221.1 ENSMUST00000093221.10 ENSMUST00000093221.11 ENSMUST00000093221.12 ENSMUST00000093221.2 ENSMUST00000093221.3 ENSMUST00000093221.4 ENSMUST00000093221.5 ENSMUST00000093221.6 ENSMUST00000093221.7 ENSMUST00000093221.8 ENSMUST00000093221.9 EST3B_MOUSE G5E8G7 G5E8K9 Gm4738 NM_144511 Q8VCU1 Q91XD5 uc009nbn.1 uc009nbn.2 uc009nbn.3 uc009nbn.4 Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence=; Endoplasmic reticulum lumen Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VCU1-1; Sequence=Displayed; Name=2; IsoId=Q8VCU1-2; Sequence=VSP_028269; Belongs to the type-B carboxylesterase/lipase family. Sequence=AAH10812.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH19147.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; sterol esterase activity triglyceride lipase activity extracellular space endoplasmic reticulum endoplasmic reticulum lumen lipid catabolic process hydrolase activity carboxylic ester hydrolase activity methyl indole-3-acetate esterase activity uc009nbn.1 uc009nbn.2 uc009nbn.3 uc009nbn.4 
ENSMUST00000093222.13 Ces3a ENSMUST00000093222.13 carboxylesterase 3A, transcript variant 1 (from RefSeq NM_198672.1) ENSMUST00000093222.1 ENSMUST00000093222.10 ENSMUST00000093222.11 ENSMUST00000093222.12 ENSMUST00000093222.2 ENSMUST00000093222.3 ENSMUST00000093222.4 ENSMUST00000093222.5 ENSMUST00000093222.6 ENSMUST00000093222.7 ENSMUST00000093222.8 ENSMUST00000093222.9 EST3A_MOUSE Es31 NM_198672 Q3UEJ0 Q3UU08 Q63880 Q6P8Z0 Q6PG74 Q810S9 uc009nbl.1 uc009nbl.2 uc009nbl.3 uc009nbl.4 Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence=; Endoplasmic reticulum lumen. Note=Microsomal membrane, lumen of endoplasmic reticulum. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q63880-1; Sequence=Displayed; Name=2; IsoId=Q63880-2; Sequence=VSP_028268; Belongs to the type-B carboxylesterase/lipase family. Sequence=AAB27606.1; Type=Frameshift; Evidence=; Sequence=AAH57187.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH57188.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; sterol esterase activity triglyceride lipase activity extracellular space endoplasmic reticulum endoplasmic reticulum lumen lipid catabolic process hydrolase activity carboxylic ester hydrolase activity methyl indole-3-acetate esterase activity uc009nbl.1 uc009nbl.2 uc009nbl.3 uc009nbl.4 
ENSMUST00000093245.13 Bean1 ENSMUST00000093245.13 brain expressed, associated with Nedd4, 1, transcript variant 2 (from RefSeq NM_001141924.2) BEAN1_MOUSE ENSMUST00000093245.1 ENSMUST00000093245.10 ENSMUST00000093245.11 ENSMUST00000093245.12 ENSMUST00000093245.2 ENSMUST00000093245.3 ENSMUST00000093245.4 ENSMUST00000093245.5 ENSMUST00000093245.6 ENSMUST00000093245.7 ENSMUST00000093245.8 ENSMUST00000093245.9 NM_001141924 Q9EQG5 uc009mzy.1 uc009mzy.2 uc009mzy.3 uc009mzy.4 uc009mzy.5 Interacts with NEDD4. Q9EQG5; P46935: Nedd4; NbExp=3; IntAct=EBI-6304006, EBI-773516; Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EQG5-1; Sequence=Displayed; Name=2; IsoId=Q9EQG5-2; Sequence=VSP_031912; Sequence=AAG44395.1; Type=Erroneous initiation; Evidence=; Sequence=AK134633; Type=Frameshift; Evidence=; protein binding cellular_component biological_process membrane integral component of membrane uc009mzy.1 uc009mzy.2 uc009mzy.3 uc009mzy.4 uc009mzy.5 
ENSMUST00000093253.10 Ccdc85a ENSMUST00000093253.10 coiled-coil domain containing 85A, transcript variant 1 (from RefSeq NM_181577.6) CC85A_MOUSE ENSMUST00000093253.1 ENSMUST00000093253.2 ENSMUST00000093253.3 ENSMUST00000093253.4 ENSMUST00000093253.5 ENSMUST00000093253.6 ENSMUST00000093253.7 ENSMUST00000093253.8 ENSMUST00000093253.9 Kiaa1912 NM_181577 Q5SP85 Q69Z68 Q6NZL9 Q8BGZ5 Q8BLC5 Q8VCC5 uc007igk.1 uc007igk.2 uc007igk.3 uc007igk.4 uc007igk.5 May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family. May interact with ARVCF; CTNND1; CTNND2 and PKP4. Cell junction, adherens junction Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5SP85-1; Sequence=Displayed; Name=2; IsoId=Q5SP85-2; Sequence=VSP_022283; Name=3; IsoId=Q5SP85-3; Sequence=VSP_022280, VSP_022283; Belongs to the CCDC85 family. Sequence=BAC39790.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. May result from internal priming due to genomic poly-A tracts.; Evidence=; Sequence=BAC39795.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. May result from internal priming due to genomic poly-A tracts.; Evidence=; Sequence=BAD32576.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc007igk.1 uc007igk.2 uc007igk.3 uc007igk.4 uc007igk.5 
ENSMUST00000093290.12 Peli1 ENSMUST00000093290.12 pellino 1 (from RefSeq NM_023324.2) ENSMUST00000093290.1 ENSMUST00000093290.10 ENSMUST00000093290.11 ENSMUST00000093290.2 ENSMUST00000093290.3 ENSMUST00000093290.4 ENSMUST00000093290.5 ENSMUST00000093290.6 ENSMUST00000093290.7 ENSMUST00000093290.8 ENSMUST00000093290.9 NM_023324 PELI1_MOUSE Q8C669 Q91YL9 Q9CV22 Q9ERJ8 uc007idl.1 uc007idl.2 uc007idl.3 E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:16951688). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with MAP3K7 (By similarity). Upon IL1B treatment, forms a complex with TRAF6, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa- B-mediated gene expression (PubMed:16951688). Interacts (via atypical FHA domain) with RIPK3 (PubMed:29883609). Binds preferentially to the 'Thr-182' phosphorylated form of RIPK3 (By similarity). Interacts with RIPK1 (PubMed:29883609). Phosphorylated by IRAK1 and IRAK4 enhancing its E3 ligase activity. Sumoylated. Belongs to the pellino family. Sequence=BAC36351.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein polyubiquitination positive regulation of cytokine production ubiquitin-protein transferase activity protein binding nucleus Toll signaling pathway regulation of Toll signaling pathway protein ubiquitination transferase activity positive regulation of B cell proliferation positive regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity response to lipopolysaccharide positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway negative regulation of T cell proliferation positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process response to dsRNA negative regulation of T cell activation positive regulation of B cell activation negative regulation of necroptotic process ubiquitin protein ligase activity protein K63-linked ubiquitination protein K48-linked ubiquitination uc007idl.1 uc007idl.2 uc007idl.3 
ENSMUST00000093292.11 Sertad2 ENSMUST00000093292.11 SERTA domain containing 2, transcript variant 1 (from RefSeq NM_021372.3) ENSMUST00000093292.1 ENSMUST00000093292.10 ENSMUST00000093292.2 ENSMUST00000093292.3 ENSMUST00000093292.4 ENSMUST00000093292.5 ENSMUST00000093292.6 ENSMUST00000093292.7 ENSMUST00000093292.8 ENSMUST00000093292.9 Kiaa0127 MNCb-1504 NM_021372 Q8C609 Q91WL3 Q925E5 Q9JJG5 SRTD2_MOUSE uc007idc.1 uc007idc.2 uc007idc.3 Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes (By similarity). Nucleus Cytoplasm Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome (By similarity). Expressed in white and brown adipose tissue. Up-regulated by high fat diet in adipose tissue. Polyubiquitinated, which promotes proteasomal degradation. Resist development of obesity because of enhanced lipolysis and thermogenesis due, in part, to an increase in brown adipocytes number. On high fat diet (HFD), show reduced white adipose tissue (WAT) weight with smaller adipocyte size, improved glucose tolerance and insulin sensitivity with lower fasting glucose and insulin concentrations. Animals on HFD have higher and lower concentrations of adiponectin and leptin, respectively, compared to wild-type. They don't develop liver steatosis and have 57% less adipose tissue macrophage infiltration. transcription coactivator activity protein binding nucleus nucleoplasm cytoplasm cytosol negative regulation of cell growth positive regulation of transcription, DNA-templated uc007idc.1 uc007idc.2 uc007idc.3 
ENSMUST00000093298.12 Spred2 ENSMUST00000093298.12 sprouty-related EVH1 domain containing 2 (from RefSeq NM_033523.4) ENSMUST00000093298.1 ENSMUST00000093298.10 ENSMUST00000093298.11 ENSMUST00000093298.2 ENSMUST00000093298.3 ENSMUST00000093298.4 ENSMUST00000093298.5 ENSMUST00000093298.6 ENSMUST00000093298.7 ENSMUST00000093298.8 ENSMUST00000093298.9 NM_033523 Q924S7 SPRE2_MOUSE uc007icr.1 uc007icr.2 uc007icr.3 Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:11493923). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879). Inhibits TGFB-induced epithelial-to- mesenchymal transition in lens epithelial cells (PubMed:25576668). Homodimer and heterodimer (By similarity). Able to interact with SPRED1 to form heterodimers (By similarity). Interacts with RAS (PubMed:11493923). May interact with ZDHHC13 (via ANK repeats) and ZDHHC17 (via ANK repeats) (PubMed:28882895). Interacts with TESK1 (PubMed:17974561). Interacts with NF1 (By similarity). Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm Note=Detected in the cytoplasm of the stratum spinosum cells, where it is associated with cytoplasmic vesicles that are supposed to be secretory granules. Predominantly expressed in lung, liver and testis. In testis, it is specially found in mature spermatids projecting into the lumen of the seminiferous. Strongly expressed in glandular epithelia. Also expressed in embryonic tissues such as heart, lung, liver and brain. Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine. Phosphorylation of Tyr-224 and Tyr-227 are required for ubiquitination. Ubiquitinated; leading to degradation by the proteasome. SPRED2 knockout results in a dwarf phenotype characterized by reduced growth and body weight, shorter tibia length, and narrower growth plates as compared with wild-type mice. Mutant animals regularly develop kyphosis and scoliosis, and show craniofacial defects, splenomegaly, and cardiac hypertrophy with arrhythmias. inactivation of MAPK activity stem cell factor receptor binding protein binding cytoplasm plasma membrane multicellular organism development regulation of signal transduction negative regulation of peptidyl-threonine phosphorylation membrane protein kinase binding protein serine/threonine kinase inhibitor activity transport vesicle membrane cytoplasmic vesicle positive regulation of DNA damage response, signal transduction by p53 class mediator regulation of protein deacetylation uc007icr.1 uc007icr.2 uc007icr.3 
ENSMUST00000093321.12 Grb10 ENSMUST00000093321.12 growth factor receptor bound protein 10, transcript variant 1 (from RefSeq NM_010345.4) ENSMUST00000093321.1 ENSMUST00000093321.10 ENSMUST00000093321.11 ENSMUST00000093321.2 ENSMUST00000093321.3 ENSMUST00000093321.4 ENSMUST00000093321.5 ENSMUST00000093321.6 ENSMUST00000093321.7 ENSMUST00000093321.8 ENSMUST00000093321.9 GRB10_MOUSE Meg1 NM_010345 O35352 Q3TQ71 Q60760 Q7TSA4 Q8BSH4 Q8BSS5 Q91WC5 uc007iba.1 uc007iba.2 uc007iba.3 uc007iba.4 Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR- 2. Phosphorylation by mTORC1 stabilizes and activates GRB10 constituting a feedback pathway by which mTORC1 inhibits INSR- dependent signaling. Interacts with ligand-activated tyrosine kinase receptors, including FGFR1, INSR, IGF1R, MET and PDGFRB in a phosphotyrosine- dependent manner through the SH2 domain. Poorly binds to the EGFR. Directly interacts with MAP3K14/NIK and is recruited to the EGFR-ERBB2 complex (By similarity). Interacts with GIGYF1/PERQ1 and GIGYF2/TNRC15. When unphosphorylated, interacts with AKT1 and when phosphorylated with YWHAE/14-3-3 epsilon. Interacts with NEDD4. Interacts with LRP6, thus interfering with the binding of AXIN1 to LRP6. Binds to activated NRAS (By similarity). Q60760; P15208: Insr; NbExp=6; IntAct=EBI-861810, EBI-6999015; Q60760; P46935: Nedd4; NbExp=7; IntAct=EBI-861810, EBI-773516; Cytoplasm Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R before the sorting of the receptor to the lysosomal compartment. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha; IsoId=Q60760-1; Sequence=Displayed; Name=2; Synonyms=Delta; IsoId=Q60760-2; Sequence=VSP_001844; Name=3; IsoId=Q60760-3; Sequence=VSP_012379; Widely expressed. At 13.5 dpc, expressed in most embryonic tissues and in placenta. At 14.5 dpc, expressed at high levels in a variety of muscle tissues, including that of the face and trunk, the intercostal muscles, the diaphragm and cardiac muscle, the tongue and limbs (at protein level). In the brain, most abundant expression in the subependymal layers, in the meninges and in the choroid plexus (both epithelium and mesenchyme) (at protein level). High levels in the liver, bronchioles and the cartilage of the atlas, ribs and long bones (at protein level). In the kidney, expression limited to the developing tubules and mesenchyme (at protein level). Also detected in the adrenal gland and pancreatic bud (at protein level). At 12.5 dpc, paternal allele expression detected in the cartilage of the limbs, ribs and face and in the meninges. At 14.5 dpc, paternal allele expressed in the cartilage of the axis, ribs, head, and long bones, in the heart, lungs, gut, umbilicus and tongue, as well as in the meninges of the fourth ventricle. Not detected in the skeletal muscle. In most tissues, paternal expression is lower than maternal. The PH domain binds relatively non-specifically to several phosphoinositides, including PI(5)P, PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3, with modest affinities. Phosphorylated on serine residues upon EGF, FGF and PDGF stimulation. Disruption of the maternal allele results in overgrowth of both the embryo and placenta such that mutant mice are at birth about 30% larger than normal. This effect occurs during embryogenesis and results in addition in disproportionate overgrowth of the liver with relative sparing of the brain. The major part of the growth phenotype seems to be IGF2-independent. The GRB10 locus is imprinted. The maternal allele is expressed in most tissues, except the brain where it is expressed from the paternal allele. Expression from the maternal allele in fetal and adult brain was however described in PubMed:10861285. [Isoform 2]: Predominant isoform in most tissues. Belongs to the GRB7/10/14 family. Sequence=AAH53842.1; Type=Erroneous initiation; Evidence=; Sequence=BAE37514.1; Type=Erroneous initiation; Evidence=; phosphotyrosine binding SH3/SH2 adaptor activity insulin receptor binding protein binding cytoplasm cytosol signal transduction insulin receptor signaling pathway negative regulation of Wnt signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway response to insulin macromolecular complex negative regulation of phosphorylation positive regulation of phosphorylation identical protein binding negative regulation of glycogen biosynthetic process negative regulation of glucose import negative regulation of insulin receptor signaling pathway insulin-like growth factor receptor signaling pathway vascular associated smooth muscle cell migration uc007iba.1 uc007iba.2 uc007iba.3 uc007iba.4 
ENSMUST00000093342.6 4933402J07Rik ENSMUST00000093342.6 RIKEN cDNA 4933402J07 gene (from RefSeq NM_177901.3) 4933402J07Rik ENSMUST00000093342.1 ENSMUST00000093342.2 ENSMUST00000093342.3 ENSMUST00000093342.4 ENSMUST00000093342.5 NM_177901 Q8BHX0 Q8BHX0_MOUSE uc009mqt.1 uc009mqt.2 uc009mqt.3 molecular_function biological_process uc009mqt.1 uc009mqt.2 uc009mqt.3 
ENSMUST00000093357.12 Wdr83 ENSMUST00000093357.12 WD repeat domain containing 83 (from RefSeq NM_026399.2) ENSMUST00000093357.1 ENSMUST00000093357.10 ENSMUST00000093357.11 ENSMUST00000093357.2 ENSMUST00000093357.3 ENSMUST00000093357.4 ENSMUST00000093357.5 ENSMUST00000093357.6 ENSMUST00000093357.7 ENSMUST00000093357.8 ENSMUST00000093357.9 Morg1 NM_026399 Q505C2 Q8VEB7 Q99JX9 Q9D235 Q9DAJ4 WDR83_MOUSE uc009mph.1 uc009mph.2 Molecular scaffold protein for various multimeric protein complexes. Involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). Also acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. May also be involved in pre-mRNA splicing. Interacts with EGLN3/PHD3. Identified in the spliceosome C complex (By similarity). Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1. Cytoplasm Nucleus Note=Predominantly cytoplasmic. Partially nuclear. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DAJ4-1; Sequence=Displayed; Name=2; IsoId=Q9DAJ4-2; Sequence=VSP_018418, VSP_018419; Name=3; IsoId=Q9DAJ4-3; Sequence=VSP_018417, VSP_018420; Ubiquitous. Belongs to the WD repeat MORG1 family. RNA splicing, via transesterification reactions mRNA splicing, via spliceosome molecular_function nucleus spliceosomal complex cytoplasm mRNA processing RNA splicing catalytic step 2 spliceosome uc009mph.1 uc009mph.2 
ENSMUST00000093369.5 Nefh ENSMUST00000093369.5 neurofilament, heavy polypeptide (from RefSeq NM_010904.3) A1E2H9 ENSMUST00000093369.1 ENSMUST00000093369.2 ENSMUST00000093369.3 ENSMUST00000093369.4 Kiaa0845 NFH_MOUSE NM_010904 Nfh P19246 Q5SVF6 Q61959 uc007hvm.1 uc007hvm.2 uc007hvm.3 Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (PubMed:22723690). Forms heterodimers with NEFL; which can further hetero- oligomerize (in vitro) (By similarity). Forms heterodimers with INA (in vitro) (By similarity). Cytoplasm, cytoskeleton Cell projection, axon Expressed in the sciatic nerve (at protein level). There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function. Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization. Belongs to the intermediate filament family. Sequence=AAA39813.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAA83229.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; microtubule cytoskeleton organization ovarian follicle atresia structural constituent of cytoskeleton nucleus cytoplasm mitochondrion cytoskeleton intermediate filament neurofilament brain development postsynaptic density toxic substance binding protein kinase binding axon protein binding, bridging axon regeneration neurofilament bundle assembly perikaryon myelin sheath intermediate filament cytoskeleton organization intermediate filament bundle assembly protein heterodimerization activity peripheral nervous system neuron axonogenesis neurofilament cytoskeleton organization axon development neurofibrillary tangle regulation of organelle transport along microtubule response to sodium arsenite cellular response to leukemia inhibitory factor uc007hvm.1 uc007hvm.2 uc007hvm.3 
ENSMUST00000093380.5 Podnl1 ENSMUST00000093380.5 podocan-like 1 (from RefSeq NM_001013384.3) A0A0R4J142 A1X874 ENSMUST00000093380.1 ENSMUST00000093380.2 ENSMUST00000093380.3 ENSMUST00000093380.4 Gm506 NM_001013384 PONL1_MOUSE Podnl1 Q6P3Y9 uc012gha.1 uc012gha.2 uc012gha.3 Secreted, extracellular space, extracellular matrix Detected in bone where it is expressed in osteoblasts and newly formed bone matrix (at protein level). Also expressed weakly in osteoclasts (at protein level). Expressed strongly in calvaria, lung and femur, and weakly in kidney. N-glycosylated. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class V subfamily. Sequence=AAH63764.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; extracellular region uc012gha.1 uc012gha.2 uc012gha.3 
ENSMUST00000093381.11 Ccdc157 ENSMUST00000093381.11 coiled-coil domain containing 157, transcript variant 1 (from RefSeq NM_001164620.1) CC157_MOUSE ENSMUST00000093381.1 ENSMUST00000093381.10 ENSMUST00000093381.2 ENSMUST00000093381.3 ENSMUST00000093381.4 ENSMUST00000093381.5 ENSMUST00000093381.6 ENSMUST00000093381.7 ENSMUST00000093381.8 ENSMUST00000093381.9 Kiaa1656 NM_001164620 Q0P531 Q3V0G5 Q5DTW1 Q5SPX1 Q8C5Y5 uc007hum.1 uc007hum.2 uc007hum.3 uc007hum.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SPX1-1; Sequence=Displayed; Name=2; IsoId=Q5SPX1-2; Sequence=VSP_031476; Sequence=BAD90260.1; Type=Erroneous initiation; Evidence=; Sequence=BAE21539.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc007hum.1 uc007hum.2 uc007hum.3 uc007hum.4 
ENSMUST00000093393.5 Tbc1d9 ENSMUST00000093393.5 TBC1 domain family, member 9, transcript variant 1 (from RefSeq NM_001111304.1) ENSMUST00000093393.1 ENSMUST00000093393.2 ENSMUST00000093393.3 ENSMUST00000093393.4 Kiaa0882 NM_001111304 Q3UYK3 Q69ZW8 Q8BIJ5 Q8BVP3 Q9CUB3 TBCD9_MOUSE uc009mjv.1 uc009mjv.2 uc009mjv.3 uc009mjv.4 May act as a GTPase-activating protein for Rab family protein(s). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UYK3-1; Sequence=Displayed; Name=2; IsoId=Q3UYK3-2; Sequence=VSP_025698; The arginine and glutamine fingers are critical for the GTPase- activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site. GTPase activator activity calcium ion binding cell intracellular protein transport Rab GTPase binding activation of GTPase activity uc009mjv.1 uc009mjv.2 uc009mjv.3 uc009mjv.4 
ENSMUST00000093427.11 Nwd1 ENSMUST00000093427.11 May play a role in the control of androgen receptor (AR) protein steady-state levels. (from UniProt A6H603) A6H603 BC082552 ENSMUST00000093427.1 ENSMUST00000093427.10 ENSMUST00000093427.2 ENSMUST00000093427.3 ENSMUST00000093427.4 ENSMUST00000093427.5 ENSMUST00000093427.6 ENSMUST00000093427.7 ENSMUST00000093427.8 ENSMUST00000093427.9 NWD1_MOUSE Q3TRC9 Q8BS99 uc292baw.1 uc292baw.2 May play a role in the control of androgen receptor (AR) protein steady-state levels. May interact with HSP90AA1, HSP90AB1 and BAG2. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=A6H603-1; Sequence=Displayed; Name=2; IsoId=A6H603-2; Sequence=VSP_028945, VSP_028946; Name=3; IsoId=A6H603-3; Sequence=VSP_028942, VSP_028945, VSP_028946; Name=4; IsoId=A6H603-4; Sequence=VSP_028943, VSP_028944; Sequence=AAI45704.1; Type=Erroneous initiation; Evidence=; Sequence=BAE37101.1; Type=Frameshift; Evidence=; nucleotide binding ATP binding cytoplasm cytosol positive regulation of gene expression negative regulation of NF-kappaB transcription factor activity uc292baw.1 uc292baw.2 
ENSMUST00000093450.6 Ano8 ENSMUST00000093450.6 anoctamin 8 (from RefSeq NM_001164679.1) ANO8_MOUSE ENSMUST00000093450.1 ENSMUST00000093450.2 ENSMUST00000093450.3 ENSMUST00000093450.4 ENSMUST00000093450.5 Kiaa1623 NM_001164679 Q05CB5 Q69ZE4 Q6PB70 Tmem16h uc009mdl.1 uc009mdl.2 uc009mdl.3 uc009mdl.4 Does not exhibit calcium-activated chloride channel (CaCC) activity. Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane. Predominant expression seen in epithelial tissues. Detected in the mantle layer of the neural tube and in the dorsal root ganglia at 14.5 dpc. The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. Belongs to the anoctamin family. Sequence=BAD32500.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; intracellular calcium activated chloride channel activity plasma membrane chloride transport membrane integral component of membrane ion transmembrane transport uc009mdl.1 uc009mdl.2 uc009mdl.3 uc009mdl.4 
ENSMUST00000093454.8 Ell ENSMUST00000093454.8 elongation factor RNA polymerase II (from RefSeq NM_007924.3) ELL_MOUSE ENSMUST00000093454.1 ENSMUST00000093454.2 ENSMUST00000093454.3 ENSMUST00000093454.4 ENSMUST00000093454.5 ENSMUST00000093454.6 ENSMUST00000093454.7 NM_007924 O08856 Q3TXY9 uc009mau.1 uc009mau.2 uc009mau.3 Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (By similarity). Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via N-terminus domain). Interacts with ICE2. Interacts with AFF4; the interaction is direct. Interacts with EAF1 and EAF2 (By similarity). Interacts with USPL1 (By similarity). Nucleus Nucleus speckle Nucleus, Cajal body Note=Colocalizes with EAF2 to nuclear speckles. Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes (By similarity). Belongs to the ELL/occludin family. in utero embryonic development nucleus transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter transcription elongation factor complex negative regulation of phosphatase activity Cajal body nuclear speck phosphatase binding positive regulation of transcription elongation from RNA polymerase II promoter transcriptionally active chromatin histone locus body snRNA transcription from RNA polymerase II promoter snRNA transcription from RNA polymerase III promoter positive regulation of transcription from RNA polymerase III promoter uc009mau.1 uc009mau.2 uc009mau.3 
ENSMUST00000093458.11 Sugp2 ENSMUST00000093458.11 SURP and G patch domain containing 2, transcript variant 2 (from RefSeq NM_172755.4) ENSMUST00000093458.1 ENSMUST00000093458.10 ENSMUST00000093458.2 ENSMUST00000093458.3 ENSMUST00000093458.4 ENSMUST00000093458.5 ENSMUST00000093458.6 ENSMUST00000093458.7 ENSMUST00000093458.8 ENSMUST00000093458.9 NM_172755 Q6PG19 Q80UY8 Q8BY32 Q8CFM0 Q8CH09 SUGP2_MOUSE Sfrs14 Srsf14 uc009lzm.1 uc009lzm.2 uc009lzm.3 uc009lzm.4 May play a role in mRNA splicing. Nucleus Sequence=AAH57305.1; Type=Frameshift; Evidence=; nucleic acid binding RNA binding nucleus nucleoplasm RNA processing mRNA processing biological_process RNA splicing nuclear body uc009lzm.1 uc009lzm.2 uc009lzm.3 uc009lzm.4 
ENSMUST00000093468.12 Psd3 ENSMUST00000093468.12 pleckstrin and Sec7 domain containing 3, transcript variant 1 (from RefSeq NM_030263.6) ENSMUST00000093468.1 ENSMUST00000093468.10 ENSMUST00000093468.11 ENSMUST00000093468.2 ENSMUST00000093468.3 ENSMUST00000093468.4 ENSMUST00000093468.5 ENSMUST00000093468.6 ENSMUST00000093468.7 ENSMUST00000093468.8 ENSMUST00000093468.9 Efa6d Kiaa0942 NM_030263 PSD3_MOUSE Q2PFD7 Q3TTA1 Q80TN6 Q80UZ7 Q8CEA6 uc009lvz.1 uc009lvz.2 uc009lvz.3 uc009lvz.4 Guanine nucleotide exchange factor for ARF6. Cell membrane Cell projection, ruffle membrane Postsynaptic density Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q2PFD7-1; Sequence=Displayed; Name=2; IsoId=Q2PFD7-2; Sequence=VSP_029160; Name=3; IsoId=Q2PFD7-3; Sequence=VSP_029157, VSP_029159, VSP_029160; Name=4; IsoId=Q2PFD7-4; Sequence=VSP_029161; Name=5; IsoId=Q2PFD7-5; Sequence=VSP_029158; Ubiquitously expressed, with highest levels in liver. Present in brain, with highest levels in olfactory bulb, cortex, hippocampal pyramidal cell layer and cerebellar granule cell layer (at protein level). Expressed only in spinal cord at 13 dpc. At 18 dpc and P0, appears weakly in forebrain. Expression in brain increases after birth and peaks at P10. guanyl-nucleotide exchange factor activity ARF guanyl-nucleotide exchange factor activity plasma membrane postsynaptic density membrane cell junction ARF protein signal transduction regulation of ARF protein signal transduction ruffle membrane cell projection synapse postsynaptic membrane cleavage furrow uc009lvz.1 uc009lvz.2 uc009lvz.3 uc009lvz.4 
ENSMUST00000093470.7 Nat2 ENSMUST00000093470.7 N-acetyltransferase 2 (arylamine N-acetyltransferase), transcript variant 2 (from RefSeq NM_001168577.1) ENSMUST00000093470.1 ENSMUST00000093470.2 ENSMUST00000093470.3 ENSMUST00000093470.4 ENSMUST00000093470.5 ENSMUST00000093470.6 NM_001168577 Nat2 Q78ZC4 Q78ZC4_MOUSE uc009lvw.1 uc009lvw.2 uc009lvw.3 uc009lvw.4 uc009lvw.5 Belongs to the arylamine N-acetyltransferase family. arylamine N-acetyltransferase activity N-acetyltransferase activity acetyltransferase activity transferase activity transferase activity, transferring acyl groups uc009lvw.1 uc009lvw.2 uc009lvw.3 uc009lvw.4 uc009lvw.5 
ENSMUST00000093494.6 Gm10283 ENSMUST00000093494.6 predicted gene 10283 (from RefSeq NR_188713.1) EG330776 ENSMUST00000093494.1 ENSMUST00000093494.2 ENSMUST00000093494.3 ENSMUST00000093494.4 ENSMUST00000093494.5 Gm10283 NR_188713 Q8C3L5 Q8C3L5_MOUSE uc292ack.1 uc292ack.2 molecular_function cellular_component biological_process uc292ack.1 uc292ack.2 
ENSMUST00000093508.7 Sp110 ENSMUST00000093508.7 Sp110 nuclear body protein, transcript variant 1 (from RefSeq NM_175397.4) ENSMUST00000093508.1 ENSMUST00000093508.2 ENSMUST00000093508.3 ENSMUST00000093508.4 ENSMUST00000093508.5 ENSMUST00000093508.6 Ifi75 Ipr1 NM_175397 Q05D41 Q3UCV7 Q80V00 Q8BVK9 SP110_MOUSE uc007btz.1 uc007btz.2 uc007btz.3 uc007btz.4 May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells. Nucleus Detected in lung and macrophages. Up-regulated after infection with M.tuberculosis. Note=Defects in Sp110 are a cause of severely impaired resistance to infection by M.tuberculosis. Sequence=AAH18413.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; immune system process DNA binding nucleus apoptotic process response to bacterium positive regulation of apoptotic process innate immune response uc007btz.1 uc007btz.2 uc007btz.3 uc007btz.4 
ENSMUST00000093526.13 Fam149a ENSMUST00000093526.13 family with sequence similarity 149, member A (from RefSeq NM_153535.2) ENSMUST00000093526.1 ENSMUST00000093526.10 ENSMUST00000093526.11 ENSMUST00000093526.12 ENSMUST00000093526.2 ENSMUST00000093526.3 ENSMUST00000093526.4 ENSMUST00000093526.5 ENSMUST00000093526.6 ENSMUST00000093526.7 ENSMUST00000093526.8 ENSMUST00000093526.9 F149A_MOUSE NM_153535 Q8CFV2 uc009lox.1 uc009lox.2 uc009lox.3 Belongs to the FAM149 family. molecular_function cellular_component biological_process uc009lox.1 uc009lox.2 uc009lox.3 
ENSMUST00000093552.12 Tomm40 ENSMUST00000093552.12 translocase of outer mitochondrial membrane 40, transcript variant 2 (from RefSeq NM_016871.2) ENSMUST00000093552.1 ENSMUST00000093552.10 ENSMUST00000093552.11 ENSMUST00000093552.2 ENSMUST00000093552.3 ENSMUST00000093552.4 ENSMUST00000093552.5 ENSMUST00000093552.6 ENSMUST00000093552.7 ENSMUST00000093552.8 ENSMUST00000093552.9 Mom35 NM_016871 Q3TBZ2 Q3TQA1 Q8VI26 Q8VI27 Q9QYA2 Q9Z2N1 TOM40_MOUSE Tom40 uc009fna.1 uc009fna.2 uc009fna.3 uc009fna.4 Channel-forming protein essential for import of protein precursors into mitochondria. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria. Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with mitochondrial targeting sequences. Interacts with TIMM29; linking the TIM22 complex to the TOM complex. Forms a complex with BCAP31 (via C-terminus) which mediates the translocation of components of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) from the cytosol to the mitochondria (By similarity). Interacts (via N-terminus) with CYP1A1 (via mitochondrial targeting signal); this interaction is required for CYP1A1 translocation across the mitochondrial outer membrane (By similarity). Mitochondrion outer membrane ; Multi-pass membrane protein Note=Associates with the mitochondria-associated ER membrane via interaction with BCAP31. Belongs to the Tom40 family. Sequence=AAC82341.1; Type=Frameshift; Evidence=; cation channel activity mitochondrion mitochondrial outer membrane mitochondrial outer membrane translocase complex mitochondrial inner membrane cytosol protein targeting to mitochondrion ion transport protein transmembrane transporter activity protein transport porin activity membrane integral component of membrane protein import into mitochondrial matrix integral component of mitochondrial outer membrane integral component of mitochondrial membrane ion transmembrane transport positive regulation of apoptotic process pore complex protein insertion into mitochondrial membrane transmembrane transport preprotein binding cation transmembrane transport uc009fna.1 uc009fna.2 uc009fna.3 uc009fna.4 
ENSMUST00000093556.3 Snora33 ENSMUST00000093556.3 small nucleolar RNA, H/ACA box 33 (from RefSeq NR_037680.1) ENSMUST00000093556.1 ENSMUST00000093556.2 NR_037680 uc287qau.1 uc287qau.2 uc287qau.1 uc287qau.2 
ENSMUST00000093557.3 Mir451a ENSMUST00000093557.3 microRNA 451a (from RefSeq NR_029971.1) ENSMUST00000093557.1 ENSMUST00000093557.2 NR_029971 uc288amb.1 uc288amb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc288amb.1 uc288amb.2 
ENSMUST00000093560.4 Mir465c-1 ENSMUST00000093560.4 microRNA 465c-1 (from RefSeq NR_030562.1) ENSMUST00000093560.1 ENSMUST00000093560.2 ENSMUST00000093560.3 NR_030562 uc012hiu.1 uc012hiu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609926.1, LM609927.1 [ECO:0000345] ##Evidence-Data-END## uc012hiu.1 uc012hiu.2 
ENSMUST00000093563.3 Mir465 ENSMUST00000093563.3 microRNA 465 (from RefSeq NR_030149.1) ENSMUST00000093563.1 ENSMUST00000093563.2 NR_030149 uc012hiy.1 uc012hiy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609389.1 [ECO:0000345] ##Evidence-Data-END## uc012hiy.1 uc012hiy.2 
ENSMUST00000093564.3 Mir433 ENSMUST00000093564.3 microRNA 433 (from RefSeq NR_029952.1) ENSMUST00000093564.1 ENSMUST00000093564.2 NR_029952 uc007pax.1 uc007pax.2 uc007pax.3 uc007pax.4 uc007pax.5 uc007pax.6 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608978.1 [ECO:0000345] ##Evidence-Data-END## uc007pax.1 uc007pax.2 uc007pax.3 uc007pax.4 uc007pax.5 uc007pax.6 
ENSMUST00000093565.3 Mir470 ENSMUST00000093565.3 microRNA 470 (from RefSeq NR_030153.1) ENSMUST00000093565.1 ENSMUST00000093565.2 NR_030153 uc012hit.1 uc012hit.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609393.1 [ECO:0000345] ##Evidence-Data-END## uc012hit.1 uc012hit.2 
ENSMUST00000093566.3 Mir484 ENSMUST00000093566.3 microRNA 484 (from RefSeq NR_030252.1) ENSMUST00000093566.1 ENSMUST00000093566.2 NR_030252 uc012abj.1 uc012abj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609524.1 [ECO:0000345] ##Evidence-Data-END## uc012abj.1 uc012abj.2 
ENSMUST00000093567.3 Mir490 ENSMUST00000093567.3 microRNA 490 (from RefSeq NR_030524.1) ENSMUST00000093567.1 ENSMUST00000093567.2 NR_030524 uc012ejy.1 uc012ejy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609764.1 [ECO:0000345] ##Evidence-Data-END## uc012ejy.1 uc012ejy.2 
ENSMUST00000093568.4 Mir127 ENSMUST00000093568.4 microRNA 127 (from RefSeq NR_029542.1) ENSMUST00000093568.1 ENSMUST00000093568.2 ENSMUST00000093568.3 NR_029542 uc288jdn.1 uc288jdn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608236.1 [ECO:0000345] ##Evidence-Data-END## uc288jdn.1 uc288jdn.2 
ENSMUST00000093569.4 Mir491 ENSMUST00000093569.4 microRNA 491 (from RefSeq NR_030478.1) ENSMUST00000093569.1 ENSMUST00000093569.2 ENSMUST00000093569.3 NR_030478 uc012dgv.1 uc012dgv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609698.1 [ECO:0000345] ##Evidence-Data-END## uc012dgv.1 uc012dgv.2 
ENSMUST00000093570.3 Mir463 ENSMUST00000093570.3 microRNA 463 (from RefSeq NR_030147.1) ENSMUST00000093570.1 ENSMUST00000093570.2 NR_030147 uc012hio.1 uc012hio.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609388.1 [ECO:0000345] ##Evidence-Data-END## uc012hio.1 uc012hio.2 
ENSMUST00000093572.3 Mir431 ENSMUST00000093572.3 microRNA 431 (from RefSeq NR_029951.1) ENSMUST00000093572.1 ENSMUST00000093572.2 NR_029951 uc011ysl.1 uc011ysl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608977.1 [ECO:0000345] ##Evidence-Data-END## uc011ysl.1 uc011ysl.2 
ENSMUST00000093573.4 Mir505 ENSMUST00000093573.4 microRNA 505 (from RefSeq NR_030499.1) ENSMUST00000093573.1 ENSMUST00000093573.2 ENSMUST00000093573.3 NR_030499 uc012hic.1 uc012hic.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609710.1 [ECO:0000345] ##Evidence-Data-END## uc012hic.1 uc012hic.2 
ENSMUST00000093576.5 Mir486 ENSMUST00000093576.5 microRNA 486 (from RefSeq NR_030254.1) ENSMUST00000093576.1 ENSMUST00000093576.2 ENSMUST00000093576.3 ENSMUST00000093576.4 NR_030254 uc012gbi.1 uc012gbi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609526.1 [ECO:0000345] ##Evidence-Data-END## uc012gbi.1 uc012gbi.2 
ENSMUST00000093591.3 Mir466 ENSMUST00000093591.3 microRNA 466 (from RefSeq NR_030150.1) ENSMUST00000093591.1 ENSMUST00000093591.2 NR_030150 uc056zks.1 uc056zks.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc056zks.1 uc056zks.2 
ENSMUST00000093592.3 Mir362 ENSMUST00000093592.3 microRNA 362 (from RefSeq NR_029851.1) ENSMUST00000093592.1 ENSMUST00000093592.2 NR_029851 uc012hea.1 uc012hea.2 uc012hea.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608687.1 [ECO:0000345] ##Evidence-Data-END## uc012hea.1 uc012hea.2 uc012hea.3 
ENSMUST00000093593.3 Mir341 ENSMUST00000093593.3 microRNA 341 (from RefSeq NR_029770.1) ENSMUST00000093593.1 ENSMUST00000093593.2 NR_029770 uc011ysq.1 uc011ysq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011ysq.1 uc011ysq.2 
ENSMUST00000093594.3 Mir455 ENSMUST00000093594.3 microRNA 455 (from RefSeq NR_030477.1) ENSMUST00000093594.1 ENSMUST00000093594.2 NR_030477 uc012dfw.1 uc012dfw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609697.1 [ECO:0000345] ##Evidence-Data-END## uc012dfw.1 uc012dfw.2 
ENSMUST00000093595.4 Mir488 ENSMUST00000093595.4 microRNA 488 (from RefSeq NR_030441.1) ENSMUST00000093595.1 ENSMUST00000093595.2 ENSMUST00000093595.3 NR_030441 uc011wuk.1 uc011wuk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609677.1 [ECO:0000345] ##Evidence-Data-END## uc011wuk.1 uc011wuk.2 
ENSMUST00000093596.3 Mir471 ENSMUST00000093596.3 microRNA 471 (from RefSeq NR_030154.1) ENSMUST00000093596.1 ENSMUST00000093596.2 NR_030154 uc012him.1 uc012him.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609394.1 [ECO:0000345] ##Evidence-Data-END## uc012him.1 uc012him.2 
ENSMUST00000093597.5 Mir495 ENSMUST00000093597.5 microRNA 495 (from RefSeq NR_030446.1) ENSMUST00000093597.1 ENSMUST00000093597.2 ENSMUST00000093597.3 ENSMUST00000093597.4 NR_030446 uc011ytl.1 uc011ytl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609682.1 [ECO:0000345] ##Evidence-Data-END## uc011ytl.1 uc011ytl.2 
ENSMUST00000093598.3 Mir363 ENSMUST00000093598.3 microRNA 363 (from RefSeq NR_029853.1) ENSMUST00000093598.1 ENSMUST00000093598.2 NR_029853 uc012hhd.1 uc012hhd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608689.1 [ECO:0000345] ##Evidence-Data-END## uc012hhd.1 uc012hhd.2 
ENSMUST00000093599.2 Mir489 ENSMUST00000093599.2 microRNA 489 (from RefSeq NR_030250.1) ENSMUST00000093599.1 NR_030250 uc012eht.1 uc012eht.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609522.1 [ECO:0000345] ##Evidence-Data-END## uc012eht.1 uc012eht.2 
ENSMUST00000093600.4 Mir500 ENSMUST00000093600.4 microRNA 500 (from RefSeq NR_030495.1) ENSMUST00000093600.1 ENSMUST00000093600.2 ENSMUST00000093600.3 NR_030495 uc012hdy.1 uc012hdy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609707.1 [ECO:0000345] ##Evidence-Data-END## uc012hdy.1 uc012hdy.2 
ENSMUST00000093601.4 Mir497b ENSMUST00000093601.4 microRNA 497b (from RefSeq NR_106178.1) ENSMUST00000093601.1 ENSMUST00000093601.2 ENSMUST00000093601.3 NR_106178 uc033fxl.1 uc033fxl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fxl.1 uc033fxl.2 
ENSMUST00000093602.4 Mir504 ENSMUST00000093602.4 microRNA 504 (from RefSeq NR_030574.1) ENSMUST00000093602.1 ENSMUST00000093602.2 ENSMUST00000093602.3 NR_030574 uc012hhz.1 uc012hhz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609941.1 [ECO:0000345] ##Evidence-Data-END## uc012hhz.1 uc012hhz.2 
ENSMUST00000093618.3 Mir199a-2 ENSMUST00000093618.3 microRNA 199a-2 (from RefSeq NR_029810.1) ENSMUST00000093618.1 ENSMUST00000093618.2 NR_029810 uc287nex.1 uc287nex.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608640.1 [ECO:0000345] ##Evidence-Data-END## uc287nex.1 uc287nex.2 
ENSMUST00000093619.4 Mir146b ENSMUST00000093619.4 microRNA 146b (from RefSeq NR_030468.1) ENSMUST00000093619.1 ENSMUST00000093619.2 ENSMUST00000093619.3 NR_030468 uc012bmy.1 uc012bmy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609689.1 [ECO:0000345] ##Evidence-Data-END## uc012bmy.1 uc012bmy.2 
ENSMUST00000093620.5 Mir485 ENSMUST00000093620.5 microRNA 485 (from RefSeq NR_030253.1) ENSMUST00000093620.1 ENSMUST00000093620.2 ENSMUST00000093620.3 ENSMUST00000093620.4 NR_030253 uc011yub.1 uc011yub.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609525.1 [ECO:0000345] ##Evidence-Data-END## uc011yub.1 uc011yub.2 
ENSMUST00000093621.4 Mir3071 ENSMUST00000093621.4 microRNA 3071 (from RefSeq NR_037232.1) ENSMUST00000093621.1 ENSMUST00000093621.2 ENSMUST00000093621.3 NR_037232 uc288jdo.1 uc288jdo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610882.1 [ECO:0000345] ##Evidence-Data-END## uc288jdo.1 uc288jdo.2 
ENSMUST00000093622.3 Mir328 ENSMUST00000093622.3 microRNA 328 (from RefSeq NR_029761.1) ENSMUST00000093622.1 ENSMUST00000093622.2 NR_029761 uc012gji.1 uc012gji.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608590.1 [ECO:0000345] ##Evidence-Data-END## uc012gji.1 uc012gji.2 
ENSMUST00000093625.3 Mir434 ENSMUST00000093625.3 microRNA 434 (from RefSeq NR_029953.1) ENSMUST00000093625.1 ENSMUST00000093625.2 NR_029953 uc011ysm.1 uc011ysm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608979.1 [ECO:0000345] ##Evidence-Data-END## uc011ysm.1 uc011ysm.2 
ENSMUST00000093627.3 Mir496a ENSMUST00000093627.3 microRNA 496a (from RefSeq NR_030437.1) ENSMUST00000093627.1 ENSMUST00000093627.2 NR_030437 uc011yue.1 uc011yue.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609672.1 [ECO:0000345] ##Evidence-Data-END## uc011yue.1 uc011yue.2 
ENSMUST00000093629.3 Mir452 ENSMUST00000093629.3 microRNA 452 (from RefSeq NR_029974.1) ENSMUST00000093629.1 ENSMUST00000093629.2 NR_029974 uc012hjv.1 uc012hjv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609035.1 [ECO:0000345] ##Evidence-Data-END## uc012hjv.1 uc012hjv.2 
ENSMUST00000093630.3 Mir532 ENSMUST00000093630.3 microRNA 532 (from RefSeq NR_030242.1) ENSMUST00000093630.1 ENSMUST00000093630.2 NR_030242 uc012hec.1 uc012hec.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609516.1 [ECO:0000345] ##Evidence-Data-END## uc012hec.1 uc012hec.2 
ENSMUST00000093631.3 Mir483 ENSMUST00000093631.3 microRNA 483 (from RefSeq NR_030251.1) ENSMUST00000093631.1 ENSMUST00000093631.2 NR_030251 uc012fxq.1 uc012fxq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609523.1 [ECO:0000345] ##Evidence-Data-END## uc012fxq.1 uc012fxq.2 
ENSMUST00000093632.4 Mir494 ENSMUST00000093632.4 microRNA 494 (from RefSeq NR_030269.1) ENSMUST00000093632.1 ENSMUST00000093632.2 ENSMUST00000093632.3 NR_030269 uc011ytg.1 uc011ytg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609539.1 [ECO:0000345] ##Evidence-Data-END## uc011ytg.1 uc011ytg.2 
ENSMUST00000093635.3 Mir1a-1 ENSMUST00000093635.3 microRNA 1a-1 (from RefSeq NR_029528.1) ENSMUST00000093635.1 ENSMUST00000093635.2 NR_029528 uc012cmb.1 uc012cmb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608222.1 [ECO:0000345] ##Evidence-Data-END## uc012cmb.1 uc012cmb.2 
ENSMUST00000093636.4 Gm23649 ENSMUST00000093636.4 Gm23649 (from geneSymbol) ENSMUST00000093636.1 ENSMUST00000093636.2 ENSMUST00000093636.3 uc289nkk.1 uc289nkk.2 uc289nkk.1 uc289nkk.2 
ENSMUST00000093641.3 n-R5s152 ENSMUST00000093641.3 n-R5s152 (from geneSymbol) AB352282 ENSMUST00000093641.1 ENSMUST00000093641.2 uc291mnu.1 uc291mnu.2 uc291mnu.1 uc291mnu.2 
ENSMUST00000093657.3 Gm25821 ENSMUST00000093657.3 Gm25821 (from geneSymbol) ENSMUST00000093657.1 ENSMUST00000093657.2 uc288fir.1 uc288fir.2 uc288fir.1 uc288fir.2 
ENSMUST00000093658.3 Snora57 ENSMUST00000093658.3 small nucleolar RNA, H/ACA box 57 (from RefSeq NR_169267.1) ENSMUST00000093658.1 ENSMUST00000093658.2 NR_169267 uc289que.1 uc289que.2 uc289que.1 uc289que.2 
ENSMUST00000093660.3 Gm24163 ENSMUST00000093660.3 Gm24163 (from geneSymbol) ENSMUST00000093660.1 ENSMUST00000093660.2 uc288orc.1 uc288orc.2 uc288orc.1 uc288orc.2 
ENSMUST00000093663.3 Gm24164 ENSMUST00000093663.3 Gm24164 (from geneSymbol) ENSMUST00000093663.1 ENSMUST00000093663.2 uc289fhz.1 uc289fhz.2 uc289fhz.1 uc289fhz.2 
ENSMUST00000093665.3 Gm24162 ENSMUST00000093665.3 Gm24162 (from geneSymbol) DQ558729 ENSMUST00000093665.1 ENSMUST00000093665.2 uc287gtj.1 uc287gtj.2 uc287gtj.1 uc287gtj.2 
ENSMUST00000093672.3 Gm24817 ENSMUST00000093672.3 Gm24817 (from geneSymbol) DQ558729 ENSMUST00000093672.1 ENSMUST00000093672.2 uc287nzl.1 uc287nzl.2 uc287nzl.1 uc287nzl.2 
ENSMUST00000093684.3 Gm22068 ENSMUST00000093684.3 Gm22068 (from geneSymbol) ENSMUST00000093684.1 ENSMUST00000093684.2 M10945 uc057klv.1 uc057klv.2 uc057klv.1 uc057klv.2 
ENSMUST00000093693.3 Gm22444 ENSMUST00000093693.3 Gm22444 (from geneSymbol) DQ558729 ENSMUST00000093693.1 ENSMUST00000093693.2 uc291qir.1 uc291qir.2 uc291qir.1 uc291qir.2 
ENSMUST00000093696.3 Rn5s-ps1 ENSMUST00000093696.3 Rn5s-ps1 (from geneSymbol) ENSMUST00000093696.1 ENSMUST00000093696.2 uc292dzh.1 uc292dzh.2 uc292dzh.1 uc292dzh.2 
ENSMUST00000093703.3 Gm23058 ENSMUST00000093703.3 Gm23058 (from geneSymbol) DQ558729 ENSMUST00000093703.1 ENSMUST00000093703.2 uc287rjk.1 uc287rjk.2 uc287rjk.1 uc287rjk.2 
ENSMUST00000093707.3 n-R5s13 ENSMUST00000093707.3 n-R5s13 (from geneSymbol) AB352282 ENSMUST00000093707.1 ENSMUST00000093707.2 uc292reu.1 uc292reu.2 uc292reu.1 uc292reu.2 
ENSMUST00000093713.3 n-R5s33 ENSMUST00000093713.3 n-R5s33 (from geneSymbol) AB349563 ENSMUST00000093713.1 ENSMUST00000093713.2 uc289efn.1 uc289efn.2 uc289efn.1 uc289efn.2 
ENSMUST00000093714.3 Gm23412 ENSMUST00000093714.3 Gm23412 (from geneSymbol) ENSMUST00000093714.1 ENSMUST00000093714.2 LF194457 uc289ohl.1 uc289ohl.2 uc289ohl.1 uc289ohl.2 
ENSMUST00000093715.3 Gm24704 ENSMUST00000093715.3 Gm24704 (from geneSymbol) ENSMUST00000093715.1 ENSMUST00000093715.2 uc290edg.1 uc290edg.2 uc290edg.1 uc290edg.2 
ENSMUST00000093721.3 Gm25313 ENSMUST00000093721.3 Gm25313 (from geneSymbol) AK089328 ENSMUST00000093721.1 ENSMUST00000093721.2 uc057lzt.1 uc057lzt.2 uc057lzt.1 uc057lzt.2 
ENSMUST00000093723.3 Gm26329 ENSMUST00000093723.3 Gm26329 (from geneSymbol) ENSMUST00000093723.1 ENSMUST00000093723.2 uc288zkm.1 uc288zkm.2 uc288zkm.1 uc288zkm.2 
ENSMUST00000093724.4 Gm26327 ENSMUST00000093724.4 Gm26327 (from geneSymbol) ENSMUST00000093724.1 ENSMUST00000093724.2 ENSMUST00000093724.3 uc291osv.1 uc291osv.2 uc291osv.1 uc291osv.2 
ENSMUST00000093750.3 Gm22365 ENSMUST00000093750.3 Gm22365 (from geneSymbol) ENSMUST00000093750.1 ENSMUST00000093750.2 uc289sou.1 uc289sou.2 uc289sou.1 uc289sou.2 
ENSMUST00000093772.4 Zbtb47 ENSMUST00000093772.4 zinc finger and BTB domain containing 47 (from RefSeq NM_001166644.1) E9PZ11 E9PZ11_MOUSE ENSMUST00000093772.1 ENSMUST00000093772.2 ENSMUST00000093772.3 NM_001166644 Zbtb47 Zfp651 uc012hcs.1 uc012hcs.2 molecular_function nucleic acid binding nucleus cellular response to DNA damage stimulus uc012hcs.1 uc012hcs.2 
ENSMUST00000093773.8 Mobp ENSMUST00000093773.8 myelin-associated oligodendrocytic basic protein, transcript variant 1 (from RefSeq NM_008614.3) ENSMUST00000093773.1 ENSMUST00000093773.2 ENSMUST00000093773.3 ENSMUST00000093773.4 ENSMUST00000093773.5 ENSMUST00000093773.6 ENSMUST00000093773.7 MOBP_MOUSE NM_008614 O35713 Q792D7 Q792D8 Q9D2P8 Q9JLY4 Q9JLY5 Q9JLY6 uc009sck.1 uc009sck.2 May play a role in compacting or stabilizing the myelin sheath possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane. Cytoplasm, perinuclear region. Note=Present in the major dense line of CNS myelin. Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=MOBP170; IsoId=Q9D2P8-1; Sequence=Displayed; Name=2; Synonyms=MOBP81; IsoId=Q9D2P8-2; Sequence=VSP_023936, VSP_023942; Name=3; Synonyms=MOBP73; IsoId=Q9D2P8-3; Sequence=VSP_023937, VSP_023941; Name=4; Synonyms=MOBP69; IsoId=Q9D2P8-4; Sequence=VSP_023938, VSP_023939; Name=5; Synonyms=MOBP74; IsoId=Q9D2P8-5; Sequence=VSP_023940, VSP_023941; cytoplasm mitochondrion cytosol structural constituent of myelin sheath myelin sheath perinuclear region of cytoplasm uc009sck.1 uc009sck.2 
ENSMUST00000093774.4 Hrnr ENSMUST00000093774.4 Cytoplasmic granule (from UniProt F8WJ23) AY027660 ENSMUST00000093774.1 ENSMUST00000093774.2 ENSMUST00000093774.3 F8WJ23 F8WJ23_MOUSE Hrnr uc290hfz.1 uc290hfz.2 Cytoplasmic granule Belongs to the S100-fused protein family. cornified envelope calcium ion binding metal ion binding transition metal ion binding uc290hfz.1 uc290hfz.2 
ENSMUST00000093775.12 Slc22a14 ENSMUST00000093775.12 solute carrier family 22 (organic cation transporter), member 14, transcript variant 2 (from RefSeq NM_001410636.1) ENSMUST00000093775.1 ENSMUST00000093775.10 ENSMUST00000093775.11 ENSMUST00000093775.2 ENSMUST00000093775.3 ENSMUST00000093775.4 ENSMUST00000093775.5 ENSMUST00000093775.6 ENSMUST00000093775.7 ENSMUST00000093775.8 ENSMUST00000093775.9 Gm1128 NM_001410636 Q497L9 S22AE_MOUSE Slc22a14 uc009sak.1 uc009sak.2 uc009sak.3 Riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa midpiece, which is required for male fertility (PubMed:33882315). SLC22A14-mediated riboflavin transport is essential for spermatozoa energy generation and motility: riboflavin is the precursor of FMN and FAD, which are coenzymes of many enzymes in the TCA cycle (the citric acid cycle) in mitochondria (PubMed:33882315). Required for sperm motility and normal sperm flagellar structure (PubMed:27811987, PubMed:33882315). Reaction=riboflavin(in) = riboflavin(out); Xref=Rhea:RHEA:35015, ChEBI:CHEBI:57986; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein Note=Localizes to the principle piece of the sperm tail. Testis-specific (at protein level) (PubMed:27811987). Specifically expressed in male germ cells (at protein level) (PubMed:27811987). Male mice show severe infertility (PubMed:27811987, PubMed:33882315). Defects are caused by impaired riboflavin transport that suppresses the oxidative phosphorylation and reprograms spermatozoa energy metabolism by disrupting flavoenzyme functions (PubMed:33882315). In mutant spermatozoa, fatty acid beta- oxidation is defective with significantly reduced levels of acyl- carnitines and metabolites from the TCA cycle (the citric acid cycle) and accumulation of triglycerides and free fatty acids (PubMed:33882315). Sperms display abnormal flagellar bending and impaired motility and capacitation (PubMed:27811987). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. membrane integral component of membrane transmembrane transporter activity transmembrane transport uc009sak.1 uc009sak.2 uc009sak.3 
ENSMUST00000093785.6 Naa80 ENSMUST00000093785.6 N(alpha)-acetyltransferase 80, NatH catalytic subunit (from RefSeq NM_019750.4) ENSMUST00000093785.1 ENSMUST00000093785.2 ENSMUST00000093785.3 ENSMUST00000093785.4 ENSMUST00000093785.5 Fus2 NAA80_MOUSE NM_019750 Naa80 Nat6 Q8QZY5 Q8R014 Q9ERM0 Q9R123 uc009rmb.1 uc009rmb.2 uc009rmb.3 N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation. In vivo, preferentially displays N- terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu. In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp. May act as a tumor suppressor. Reaction=acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl- [protein] = CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L- aspartyl-[protein]; Xref=Rhea:RHEA:57328, Rhea:RHEA-COMP:14863, Rhea:RHEA-COMP:14864, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:141602, ChEBI:CHEBI:141604; Evidence=; Reaction=acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl- [protein] = CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L- glutamyl-[protein]; Xref=Rhea:RHEA:57324, Rhea:RHEA-COMP:14865, Rhea:RHEA-COMP:14866, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:141603, ChEBI:CHEBI:141606; Evidence=; Cytoplasm, cytosol Belongs to the acetyltransferase family. peptide alpha-N-acetyltransferase activity cytoplasm cytosol protein acetylation regulation of actin polymerization or depolymerization N-acetyltransferase activity transferase activity transferase activity, transferring acyl groups N-terminal peptidyl-aspartic acid acetylation N-terminal peptidyl-glutamic acid acetylation actin modification acetyl-CoA binding uc009rmb.1 uc009rmb.2 uc009rmb.3 
ENSMUST00000093786.9 Rassf1 ENSMUST00000093786.9 Ras association (RalGDS/AF-6) domain family member 1, transcript variant 1 (from RefSeq NM_001243748.2) ENSMUST00000093786.1 ENSMUST00000093786.2 ENSMUST00000093786.3 ENSMUST00000093786.4 ENSMUST00000093786.5 ENSMUST00000093786.6 ENSMUST00000093786.7 ENSMUST00000093786.8 NM_001243748 Q99MK9 Q9WUF5 RASF1_MOUSE Rassf1 uc012hag.1 uc012hag.2 uc012hag.3 Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage (By similarity). Interacts with MAP1S and XPA (By similarity). Binds to the N- terminal of CDC20 during prometaphase (By similarity). Binds to STK3/MST2 and STK4/MST1 (By similarity). Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization (By similarity). Can self-associate (By similarity). Part of a complex with MDM2, DAXX, RASSF1 and USP7 (By similarity). [Isoform A]: Interacts with MOAP1 and E4F1 (By similarity). Interacts with RSSF5 and probably associates with HRAS via a RSSF1 isoform A-RSSF5 heterodimer (By similarity). Interacts (via C-terminus) with DAXX (via N-terminus); the interaction is independent of MDM2 and TP53 (By similarity). Interacts (via N-terminus) with MDM2 (via C- terminus); the interaction is independent of TP53 (By similarity). Interacts with RAB39A (PubMed:23294242). Interacts with RAB39B; the interaction is weak (PubMed:23294242). [Isoform C]: Interacts with ECM2 (PubMed:17335777). Interacts with RAB39B; the interaction is strong (PubMed:23294242). Does not interact with RAB39A (PubMed:23294242). [Isoform A]: Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus (By similarity). [Isoform C]: Nucleus Note=Predominantly nuclear. Event=Alternative promoter usage; Named isoforms=2; Name=A; IsoId=Q99MK9-1; Sequence=Displayed; Name=C; IsoId=Q99MK9-2; Sequence=VSP_050779, VSP_050780; spindle pole protein binding nucleus cytoplasm microtubule organizing center spindle cytoskeleton microtubule cellular response to DNA damage stimulus cell cycle cell cycle arrest signal transduction Ras protein signal transduction microtubule cytoskeleton positive regulation of protein ubiquitination intracellular signal transduction identical protein binding metal ion binding protein heterodimerization activity protein N-terminus binding protein stabilization regulation of microtubule cytoskeleton organization negative regulation of cell cycle arrest uc012hag.1 uc012hag.2 uc012hag.3 
ENSMUST00000093792.4 Slc35g2 ENSMUST00000093792.4 solute carrier family 35, member G2 (from RefSeq NM_001101483.1) D3YVE8 ENSMUST00000093792.1 ENSMUST00000093792.2 ENSMUST00000093792.3 NM_001101483 S35G2_MOUSE Tmem22 uc012gze.1 uc012gze.2 uc012gze.3 Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Belongs to the SLC35G solute transporter family. molecular_function Golgi apparatus plasma membrane biological_process membrane integral component of membrane uc012gze.1 uc012gze.2 uc012gze.3 
ENSMUST00000093795.10 Cep70 ENSMUST00000093795.10 centrosomal protein 70 (from RefSeq NM_023873.4) CEP70_MOUSE ENSMUST00000093795.1 ENSMUST00000093795.2 ENSMUST00000093795.3 ENSMUST00000093795.4 ENSMUST00000093795.5 ENSMUST00000093795.6 ENSMUST00000093795.7 ENSMUST00000093795.8 ENSMUST00000093795.9 NM_023873 Q3V0L8 Q6IQY5 Q9CRL9 Q9CTS4 Q9JIC1 uc009rdz.1 uc009rdz.2 uc009rdz.3 uc009rdz.4 Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle (By similarity). Directly interacts with tubulin-gamma; this interaction determines centrosomal localization. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6IQY5-1; Sequence=Displayed; Name=2; IsoId=Q6IQY5-2; Sequence=VSP_042142, VSP_042143; The coiled-coil domains may be important for tubulin-gamma- binding and hence for centrosomal localization. Sequence=AAF97768.1; Type=Frameshift; Evidence=; nucleoplasm cytoplasm centrosome microtubule organizing center cytosol cytoskeleton biological_process nuclear membrane identical protein binding gamma-tubulin binding cilium assembly regulation of microtubule cytoskeleton organization uc009rdz.1 uc009rdz.2 uc009rdz.3 uc009rdz.4 
ENSMUST00000093800.9 Pls1 ENSMUST00000093800.9 plastin 1 (I-isoform) (from RefSeq NM_001033210.3) ENSMUST00000093800.1 ENSMUST00000093800.2 ENSMUST00000093800.3 ENSMUST00000093800.4 ENSMUST00000093800.5 ENSMUST00000093800.6 ENSMUST00000093800.7 ENSMUST00000093800.8 NM_001033210 PLSI_MOUSE Q3V0K9 uc009rbk.1 uc009rbk.2 uc009rbk.3 uc009rbk.4 Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions (PubMed:27811163). Monomer. Cytoplasm Cell projection, stereocilium In the inner ear, it is expressed in the organ of Corti (PubMed:25124451). Abundant in the utricle (at protein level) (PubMed:27811163). Phosphorylated. Knockout animals have a progressive form of hearing loss at all frequencies. Hearing loss is moderate in young adult mice, progresses to severe deafness with age, and is associated with defects in stereocilia morphology. Stereocilia are shorter and narrower than those of wild-type mice. intestinal D-glucose absorption actin binding calcium ion binding protein binding cytoplasm actin filament brush border actin filament bundle regulation of microvillus length positive regulation of multicellular organism growth metal ion binding actin filament binding actin filament bundle assembly actin filament network formation terminal web assembly positive regulation of protein localization to plasma membrane terminal web microvillus assembly uc009rbk.1 uc009rbk.2 uc009rbk.3 uc009rbk.4 
ENSMUST00000093801.10 Plscr1 ENSMUST00000093801.10 phospholipid scramblase 1, transcript variant 1 (from RefSeq NM_011636.3) ENSMUST00000093801.1 ENSMUST00000093801.2 ENSMUST00000093801.3 ENSMUST00000093801.4 ENSMUST00000093801.5 ENSMUST00000093801.6 ENSMUST00000093801.7 ENSMUST00000093801.8 ENSMUST00000093801.9 NM_011636 O54730 O54731 PLS1_MOUSE Q9D1F8 Q9JJ00 Tra1b Tras1 uc009ram.1 uc009ram.2 uc009ram.3 uc009ram.4 Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific distribution of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:32110987). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (PubMed:32110987). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (By similarity). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724). May contribute to cytokine-regulated cell proliferation and differentiation (PubMed:12010804). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38572; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38573; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2- diacyl-sn-glycero-3-phosphoethanolamine(out); Xref=Rhea:RHEA:38895, ChEBI:CHEBI:64612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38896; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38664; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38665; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Magnesium. Can also use zinc with lower efficiency. ; Forms homooligomers in the presence of calcium (By similarity). Interacts with ABL (By similarity). Interacts with RELT, RELL1 and RELL2 (By similarity). Interacts with OXSR1 in the presence of RELT (By similarity). Interacts with OCLN, TOP2A and TOP2B (By similarity). Interacts with TRPC1, TRPC4 and TRPC5 (PubMed:32110987). Interacts with ILDR1 (By similarity). Cell membrane ; Single-pass type II membrane protein Cell membrane ; Lipid-anchor ; Cytoplasmic side. Nucleus Cytoplasm Cytoplasm, perinuclear region Note=Localizes to the perinuclear region in the presence of RELT. Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. Highly expressed in kidney, lung, liver and bone marrow, slightly in spleen, heart and macrophage. Up-regulated by SCF/KITL and GCSF/CSF3. The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity. The transmembrane domain is essential for membrane insertion, phospholipid scramblase activity and proper calcium-binding. Phosphorylation at Thr-170 by PKC/PKCD increases its phospholipid scramblase activity during both cell stimulation and apoptosis (By similarity). Phosphorylated by OXSR1 in the presence of RELT (By similarity). Palmitoylation is required for its phospholipid scramblase activity (By similarity). Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus (By similarity). Note=Participates in a chromosomal translocation that produces MMTRA1A which is leukemogenic to syngenic SL mice and athymic nude mice. Knockout newborn mice display a reduced granulocyte production (PubMed:12010804). Hematopoietic precursor cell from knockout mice display defective colony formation and impaired differentiation to mature granulocytes as stimulated by SCF/KITL and GCSF/CSF3 (PubMed:12010804). Deletion mutant mice start to die at 3 days post-infection after influenza H1N1 challenge, and the survival rate drops to 50% at 28 days post-infection showing lower survival rate than WT mice. Belongs to the phospholipid scramblase family. Sequence=BAA23663.1; Type=Erroneous initiation; Evidence=; Sequence=BAA23664.1; Type=Frameshift; Evidence=; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding epidermal growth factor receptor binding calcium ion binding nucleus nucleolus cytoplasm Golgi apparatus cytosol plasma membrane integral component of plasma membrane phosphatidylserine biosynthetic process apoptotic process acute-phase response immune response positive regulation of gene expression membrane integral component of membrane phospholipid scrambling SH3 domain binding phospholipid scramblase activity enzyme binding myeloid cell differentiation negative regulation of protein binding regulation of mast cell activation response to interferon-alpha response to interferon-beta CD4 receptor binding positive regulation of apoptotic process negative regulation of viral genome replication positive regulation of innate immune response membrane raft positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm defense response to virus regulation of Fc receptor mediated stimulatory signaling pathway phosphatidylserine exposure on apoptotic cell surface cellular response to lipopolysaccharide cellular response to cytokine stimulus intrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity uc009ram.1 uc009ram.2 uc009ram.3 uc009ram.4 
ENSMUST00000093802.6 Cep162 ENSMUST00000093802.6 centrosomal protein 162 (from RefSeq NM_199316.2) B9EKN3 CE162_MOUSE ENSMUST00000093802.1 ENSMUST00000093802.2 ENSMUST00000093802.3 ENSMUST00000093802.4 ENSMUST00000093802.5 Kiaa1009 NM_199316 Q6P262 Q6ZQ06 Qn1 uc009qyg.1 uc009qyg.2 uc009qyg.3 Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules (By similarity). Interacts with CPNE4 (PubMed:12522145). Interacts with alpha- tubulin. Interacts with CEP290 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle Nucleus Note=Localizes to the distal end of centrioles throughout the cell cycle. During ciliogenesis, found at the cilia base. Localizes to spindle microtubules during mitosis (By similarity). Belongs to the CEP162 family. protein binding nucleus cytoplasm centrosome centriole spindle cytoskeleton microtubule axonemal microtubule cell projection organization cilium assembly uc009qyg.1 uc009qyg.2 uc009qyg.3 
ENSMUST00000093811.11 Filip1 ENSMUST00000093811.11 filamin A interacting protein 1, transcript variant 3 (from RefSeq NM_001357353.2) ENSMUST00000093811.1 ENSMUST00000093811.10 ENSMUST00000093811.2 ENSMUST00000093811.3 ENSMUST00000093811.4 ENSMUST00000093811.5 ENSMUST00000093811.6 ENSMUST00000093811.7 ENSMUST00000093811.8 ENSMUST00000093811.9 FLIP1_MOUSE NM_001357353 Q059P4 Q9CS72 uc009quy.1 uc009quy.2 uc009quy.3 By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. Interacts with FLNA. Interacts with RHOD (in GTP-bound form). Cytoplasm, cytoskeleton Belongs to the FILIP1 family. Sequence=BAB30888.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function nucleolus cytoplasm cytoskeleton plasma membrane actin cytoskeleton postsynaptic actin cytoskeleton glutamatergic synapse modification of postsynaptic structure uc009quy.1 uc009quy.2 uc009quy.3 
ENSMUST00000093812.5 Cd109 ENSMUST00000093812.5 CD109 antigen (from RefSeq NM_153098.3) CD109_MOUSE ENSMUST00000093812.1 ENSMUST00000093812.2 ENSMUST00000093812.3 ENSMUST00000093812.4 NM_153098 Q8BLT6 Q8R422 uc009qur.1 uc009qur.2 uc009qur.3 uc009qur.4 Modulates negatively TGFB1 signaling in keratinocytes. Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner (By similarity). Cell membrane ; Lipid-anchor, GPI- anchor N-glycosylated. 2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. Sequence=BAC31190.1; Type=Erroneous initiation; Evidence=; negative regulation of protein phosphorylation hair follicle development endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity extracellular region extracellular space plasma membrane negative regulation of peptidase activity negative regulation of keratinocyte proliferation negative regulation of endopeptidase activity membrane peptidase inhibitor activity negative regulation of transforming growth factor beta receptor signaling pathway anchored component of membrane regulation of keratinocyte differentiation transforming growth factor beta binding negative regulation of wound healing osteoclast fusion uc009qur.1 uc009qur.2 uc009qur.3 uc009qur.4 
ENSMUST00000093813.12 Arhgef40 ENSMUST00000093813.12 Rho guanine nucleotide exchange factor 40, transcript variant 1 (from RefSeq NM_198249.4) ARH40_MOUSE ENSMUST00000093813.1 ENSMUST00000093813.10 ENSMUST00000093813.11 ENSMUST00000093813.2 ENSMUST00000093813.3 ENSMUST00000093813.4 ENSMUST00000093813.5 ENSMUST00000093813.6 ENSMUST00000093813.7 ENSMUST00000093813.8 ENSMUST00000093813.9 NM_198249 Q3U1X1 Q3UGT7 Q3UPH7 Q3UYX3 Q6KAS1 Q6PD04 Q6PDY3 Solo uc007tnr.1 uc007tnr.2 uc007tnr.3 uc007tnr.4 May act as a guanine nucleotide exchange factor (GEF). Cytoplasm Note=Concentrated in the perinuclear region. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3UPH7-1; Sequence=Displayed; Name=2; IsoId=Q3UPH7-2; Sequence=VSP_030387, VSP_030388; Name=3; IsoId=Q3UPH7-3; Sequence=VSP_030387; Name=6; IsoId=Q3UPH7-6; Sequence=VSP_030387, VSP_030389; Ubiquitously expressed but enriched in brain. In brain, it is expressed at higher level in olfactory bulb and cerebellum and peaks perinatally (from 16 dpc to P0.5). [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=AAH58405.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD21386.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE22088.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=BAE33372.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; molecular_function guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cellular_component cytoplasm biological_process regulation of Rho protein signal transduction uc007tnr.1 uc007tnr.2 uc007tnr.3 uc007tnr.4 
ENSMUST00000093823.8 Myzap ENSMUST00000093823.8 myocardial zonula adherens protein (from RefSeq NM_001033208.4) B2RT00 ENSMUST00000093823.1 ENSMUST00000093823.2 ENSMUST00000093823.3 ENSMUST00000093823.4 ENSMUST00000093823.5 ENSMUST00000093823.6 ENSMUST00000093823.7 MYZAP_MOUSE Myozap NM_001033208 Q3UIJ9 uc009qpa.1 uc009qpa.2 Plays a role in cellular signaling via Rho-related GTP- binding proteins and activation of transcription factor SRF. Targets TJP1 to cell junctions (By similarity). In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity). Interacts with DSP, MPRIP and TJP1/ZO1. Interaction with MPRIP inhibits the activation of transcription factor SRF. Interacts with GRIN1. Interacts with DYNLL1 (By similarity). Cytoplasm, cytoskeleton Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, myofibril, sarcomere, I band Cytoplasm, myofibril, sarcomere, Z line Cell junction Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin. Detected in heart myocardium and lung. Detected in embryonic vasculature at 8 dpc. Detected in endocardium and the primitive ventricle at 9 dpc. First detected in myocardium at 11.5 dpc. Highly expressed in heart and lung at 15.5 dpc and in neonates, wherease expression in vasculature is no longer detectable. Belongs to the MYZAP family. protein binding cytoplasm cytoskeleton plasma membrane membrane Z disc cell junction cortical actin cytoskeleton extrinsic component of cytoplasmic side of plasma membrane I band intracellular signal transduction uc009qpa.1 uc009qpa.2 
ENSMUST00000093832.11 Lman1l ENSMUST00000093832.11 lectin, mannose-binding 1 like (from RefSeq NM_199222.3) ENSMUST00000093832.1 ENSMUST00000093832.10 ENSMUST00000093832.2 ENSMUST00000093832.3 ENSMUST00000093832.4 ENSMUST00000093832.5 ENSMUST00000093832.6 ENSMUST00000093832.7 ENSMUST00000093832.8 ENSMUST00000093832.9 Ergl LMA1L_MOUSE NM_199222 Q4H2F4 Q8VCD3 uc009pvi.1 uc009pvi.2 uc009pvi.3 uc009pvi.4 Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VCD3-1; Sequence=Displayed; Name=2; IsoId=Q8VCD3-2; Sequence=VSP_039811, VSP_039812; Golgi membrane mannose binding endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment ER to Golgi vesicle-mediated transport endoplasmic reticulum organization Golgi organization membrane integral component of membrane ER to Golgi transport vesicle carbohydrate binding endoplasmic reticulum-Golgi intermediate compartment membrane uc009pvi.1 uc009pvi.2 uc009pvi.3 uc009pvi.4 
ENSMUST00000093837.5 Trcg1 ENSMUST00000093837.5 taste receptor cell gene 1 (from RefSeq NM_001014398.2) ENSMUST00000093837.1 ENSMUST00000093837.2 ENSMUST00000093837.3 ENSMUST00000093837.4 F8VPJ5 F8VPJ5_MOUSE NM_001014398 Trcg1 uc009puo.1 uc009puo.2 uc009puo.1 uc009puo.2 
ENSMUST00000093852.5 Zbtb16 ENSMUST00000093852.5 zinc finger and BTB domain containing 16, transcript variant 3 (from RefSeq NM_001410497.1) ENSMUST00000093852.1 ENSMUST00000093852.2 ENSMUST00000093852.3 ENSMUST00000093852.4 NM_001410497 Q3UQ17 Q3UQ17_MOUSE Zbtb16 uc009pil.1 uc009pil.2 Nucleus negative regulation of transcription from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development mesonephros development nucleic acid binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytosol plasma membrane regulation of transcription, DNA-templated central nervous system development protein C-terminus binding negative regulation of cell proliferation embryonic pattern specification anterior/posterior pattern specification nuclear body PML body nuclear speck transcriptional repressor complex protein domain specific binding hemopoiesis positive regulation of chondrocyte differentiation macromolecular complex protein localization to nucleus embryonic hindlimb morphogenesis forelimb morphogenesis hindlimb morphogenesis embryonic digit morphogenesis identical protein binding protein homodimerization activity positive regulation of apoptotic process positive regulation of fat cell differentiation negative regulation of myeloid cell differentiation positive regulation of ossification negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated male germ-line stem cell asymmetric division positive regulation of NK T cell differentiation cartilage development positive regulation of cartilage development uc009pil.1 uc009pil.2 
ENSMUST00000093865.3 Or8c8 ENSMUST00000093865.3 olfactory receptor family 8 subfamily C member 8 (from RefSeq NM_146806.2) ENSMUST00000093865.1 ENSMUST00000093865.2 F8VQN7 F8VQN7_MOUSE NM_146806 Olfr143 Or8c8 uc009owc.1 uc009owc.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009owc.1 uc009owc.2 
ENSMUST00000093866.3 Or8c16 ENSMUST00000093866.3 olfactory receptor family 8 subfamily C member 16 (from RefSeq NM_146868.2) E9PYB6 E9PYB7 ENSMUST00000093866.1 ENSMUST00000093866.2 NM_146868 Olfr893 Olfr894 Or8c16 Q9EQB2 Q9EQB2_MOUSE uc009owb.1 uc009owb.2 uc009owb.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009owb.1 uc009owb.2 uc009owb.3 
ENSMUST00000093867.3 Or8c15 ENSMUST00000093867.3 olfactory receptor family 8 subfamily C member 15 (from RefSeq NM_146336.2) ENSMUST00000093867.1 ENSMUST00000093867.2 K7N678 K7N678_MOUSE NM_146336 Olfr893 Or8c15 uc009owa.1 uc009owa.2 uc009owa.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC130242.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009owa.1 uc009owa.2 uc009owa.3 
ENSMUST00000093868.9 Pate14 ENSMUST00000093868.9 prostate and testis expressed 14 (from RefSeq NM_001033325.3) ENSMUST00000093868.1 ENSMUST00000093868.2 ENSMUST00000093868.3 ENSMUST00000093868.4 ENSMUST00000093868.5 ENSMUST00000093868.6 ENSMUST00000093868.7 ENSMUST00000093868.8 NM_001033325 PAT14_MOUSE Pate14 Q3UN54 Sslp1 uc009otr.1 uc009otr.2 Monomer. Secreted Predominantly expressed in the seminal vesicles (PubMed:16940290). Expressed in prostate, and to a lesser extent in the cauda epididymis (PubMed:21942998). Expressed from 3 weeks onwards. By testosterone. Glycosylated. Belongs to the PATE family. extracellular region extracellular space uc009otr.1 uc009otr.2 
ENSMUST00000093873.9 4930581F22Rik ENSMUST00000093873.9 RIKEN cDNA 4930581F22 gene (from RefSeq NR_029475.1) ENSMUST00000093873.1 ENSMUST00000093873.2 ENSMUST00000093873.3 ENSMUST00000093873.4 ENSMUST00000093873.5 ENSMUST00000093873.6 ENSMUST00000093873.7 ENSMUST00000093873.8 NR_029475 uc009oso.1 uc009oso.2 uc009oso.1 uc009oso.2 
ENSMUST00000093893.12 Arhgap42 ENSMUST00000093893.12 Rho GTPase activating protein 42, transcript variant 3 (from RefSeq NM_027823.2) Arhgap42 B2RQE8 ENSMUST00000093893.1 ENSMUST00000093893.10 ENSMUST00000093893.11 ENSMUST00000093893.2 ENSMUST00000093893.3 ENSMUST00000093893.4 ENSMUST00000093893.5 ENSMUST00000093893.6 ENSMUST00000093893.7 ENSMUST00000093893.8 ENSMUST00000093893.9 Graf3 NM_027823 RHG42_MOUSE uc012gnz.1 uc012gnz.2 uc012gnz.3 May influence blood pressure by functioning as a GTPase- activating protein for RHOA in vascular smooth muscle. Highly and selectively expressed in smooth muscle cells. negative regulation of systemic arterial blood pressure GTPase activator activity signal transduction negative regulation of Rho protein signal transduction activation of GTPase activity negative regulation of vascular smooth muscle contraction uc012gnz.1 uc012gnz.2 uc012gnz.3 
ENSMUST00000093901.12 Tepsin ENSMUST00000093901.12 TEPSIN, adaptor related protein complex 4 accessory protein (from RefSeq NM_183137.2) AP4AT_MOUSE ENSMUST00000093901.1 ENSMUST00000093901.10 ENSMUST00000093901.11 ENSMUST00000093901.2 ENSMUST00000093901.3 ENSMUST00000093901.4 ENSMUST00000093901.5 ENSMUST00000093901.6 ENSMUST00000093901.7 ENSMUST00000093901.8 ENSMUST00000093901.9 Enthd2 NM_183137 Q3U3N6 Q8C1H2 Tepsin uc007mrq.1 uc007mrq.2 uc007mrq.3 Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Interacts with AP4B1 and AP4E1; the interaction is direct and mediates the association of TEPSIN with the adapter-like complex 4 (AP- 4), a heterotetramer composed of AP4B1, AP4E1, AP4M1 and AP4S1. Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Cytoplasmic vesicle Cytoplasm, cytosol Note=Extensively colocalizes with AP-4 which mediates the recruitment of TEPSIN to the trans-Golgi network. Sequence=BAC25578.1; Type=Frameshift; Evidence=; molecular_function cytoplasm Golgi apparatus cytosol biological_process membrane nuclear speck AP-4 adaptor complex coated vesicle membrane extrinsic component of organelle membrane cytoplasmic vesicle nuclear membrane trans-Golgi network membrane uc007mrq.1 uc007mrq.2 uc007mrq.3 
ENSMUST00000093902.12 Rnf213 ENSMUST00000093902.12 ring finger protein 213 (from RefSeq NM_001040005.3) A0A8I4P9C4 A0A8I4P9C4_MOUSE ENSMUST00000093902.1 ENSMUST00000093902.10 ENSMUST00000093902.11 ENSMUST00000093902.2 ENSMUST00000093902.3 ENSMUST00000093902.4 ENSMUST00000093902.5 ENSMUST00000093902.6 ENSMUST00000093902.7 ENSMUST00000093902.8 ENSMUST00000093902.9 NM_001040005 Rnf213 uc007mqo.1 uc007mqo.2 uc007mqo.3 uc007mqo.1 uc007mqo.2 uc007mqo.3 
ENSMUST00000093905.3 Tmem235 ENSMUST00000093905.3 transmembrane protein 235 (from RefSeq NM_001085535.1) B1AQL3 Cldn27 ENSMUST00000093905.1 ENSMUST00000093905.2 Gm12581 NM_001085535 TM235_MOUSE uc007mof.1 uc007mof.2 Membrane ; Multi-pass membrane protein Endoplasmic reticulum N-glycosylated. Belongs to the PMP-22/EMP/MP20 family. molecular_function cytoplasm endoplasmic reticulum biological_process membrane integral component of membrane apical plasma membrane uc007mof.1 uc007mof.2 
ENSMUST00000093909.12 Qrich2 ENSMUST00000093909.12 Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility. (from UniProt Q3V2A7) AK131945 B9EKM0 ENSMUST00000093909.1 ENSMUST00000093909.10 ENSMUST00000093909.11 ENSMUST00000093909.2 ENSMUST00000093909.3 ENSMUST00000093909.4 ENSMUST00000093909.5 ENSMUST00000093909.6 ENSMUST00000093909.7 ENSMUST00000093909.8 ENSMUST00000093909.9 Gm66 Q3V2A7 QRIC2_MOUSE Qrich2 uc288dss.1 uc288dss.2 Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility. Interacts with AKAP3, ODF2 and TSSK4. Nucleus membrane Nucleus Cytoplasm Cell projection, cilium, flagellum Note=Localization varies during spermatozoa development. The protein is distributed in the nuclear membrane of the spermatogonia, in the nucleus of round spermatids, in the nucleus and cytoplasm of early elongating spermatids, in the cytoplasm of late elongating spermatids, and in the flagella of epididymal spermatozoa. Expressed in testis (PubMed:30683861). Not detected in heart, brain, kidney, stomach, ovary, liver, lung and uterus. Significant expression begins at postnatal day 15 and reaches a peak at postnatal day 22. Stable and high expression is detected after postnatal day 22. Knockout mice show coiled, bent, irregular, short or absent flagella, defects of sperm flagellar ultrastructure, a significant reduction in sperm locomotion, and decreased sperm count. molecular_function nucleus cytoplasm cell projection assembly flagellated sperm motility sperm flagellum negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc288dss.1 uc288dss.2 
ENSMUST00000093911.11 Myo15b ENSMUST00000093911.11 myosin XVB (from RefSeq NM_001384233.2) ENSMUST00000093911.1 ENSMUST00000093911.10 ENSMUST00000093911.2 ENSMUST00000093911.3 ENSMUST00000093911.4 ENSMUST00000093911.5 ENSMUST00000093911.6 ENSMUST00000093911.7 ENSMUST00000093911.8 ENSMUST00000093911.9 I7HPW8 I7HPW8_MOUSE Myo15b NM_001384233 uc288dot.1 uc288dot.2 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. nucleotide binding molecular_function motor activity actin binding ATP binding cytoskeleton brush border biological_process myosin complex uc288dot.1 uc288dot.2 
ENSMUST00000093912.11 Tmem94 ENSMUST00000093912.11 transmembrane protein 94 (from RefSeq NM_028014.3) B1AT99 ENSMUST00000093912.1 ENSMUST00000093912.10 ENSMUST00000093912.2 ENSMUST00000093912.3 ENSMUST00000093912.4 ENSMUST00000093912.5 ENSMUST00000093912.6 ENSMUST00000093912.7 ENSMUST00000093912.8 ENSMUST00000093912.9 Kiaa0195 NM_028014 Q7TSH8 Q80U66 Q8BL05 Q8K0Q0 Q91VY1 TMM94_MOUSE Tmem94 uc007mil.1 uc007mil.2 uc007mil.3 Membrane ; Multi-pass membrane protein Deficient mice are embryonic lethal and exhibit craniofacial defects, cardiac abnormalities, and abnormal neuronal migration in the central nervous system. Sequence=BAC65499.1; Type=Erroneous initiation; Evidence=; molecular_function biological_process membrane integral component of membrane uc007mil.1 uc007mil.2 uc007mil.3 
ENSMUST00000093914.5 Trim80 ENSMUST00000093914.5 tripartite motif-containing 80 (from RefSeq NM_001033775.3) 4933422H20Rik ENSMUST00000093914.1 ENSMUST00000093914.2 ENSMUST00000093914.3 ENSMUST00000093914.4 NM_001033775 Q3V061 Q3V061_MOUSE Trim80 uc007mho.1 uc007mho.2 uc007mho.3 molecular_function cellular_component biological_process zinc ion binding metal ion binding uc007mho.1 uc007mho.2 uc007mho.3 
ENSMUST00000093923.9 Cdc27 ENSMUST00000093923.9 cell division cycle 27, transcript variant 2 (from RefSeq NM_145436.3) A2A6Q5 A2A6Q6 B2RXS0 CDC27_MOUSE ENSMUST00000093923.1 ENSMUST00000093923.2 ENSMUST00000093923.3 ENSMUST00000093923.4 ENSMUST00000093923.5 ENSMUST00000093923.6 ENSMUST00000093923.7 ENSMUST00000093923.8 NM_145436 uc007lwq.1 uc007lwq.2 uc007lwq.3 uc007lwq.4 uc007lwq.5 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Protein modification; protein ubiquitination. Homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (By similarity). Interacts with RB. Interacts with FAM168B/MANI (PubMed:20716133). Interacts with MCPH1 (By similarity). Nucleus Cytoplasm, cytoskeleton, spindle Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2A6Q5-1; Sequence=Displayed; Name=2; IsoId=A2A6Q5-2; Sequence=VSP_038534, VSP_038535; Name=3; IsoId=A2A6Q5-3; Sequence=VSP_038534; Phosphorylated. Phosphorylation on Ser-427 and Thr-447 occurs specifically during mitosis (By similarity). Belongs to the APC3/CDC27 family. nucleus nucleoplasm anaphase-promoting complex cytoplasm centrosome spindle microtubule metaphase/anaphase transition of mitotic cell cycle protein ubiquitination protein phosphatase binding protein K11-linked ubiquitination uc007lwq.1 uc007lwq.2 uc007lwq.3 uc007lwq.4 uc007lwq.5 
ENSMUST00000093925.5 Crhr1 ENSMUST00000093925.5 corticotropin releasing hormone receptor 1, transcript variant 1 (from RefSeq NM_007762.5) Crhr1 ENSMUST00000093925.1 ENSMUST00000093925.2 ENSMUST00000093925.3 ENSMUST00000093925.4 NM_007762 Q3ZAT0 Q3ZAT0_MOUSE uc007lvz.1 uc007lvz.2 uc007lvz.3 uc007lvz.4 The protein encoded by this gene is a G-protein coupled receptor that binds corticotropin-releasing factor (CRH) and urocortin (UCN) with high affinity. The encoded protein upregulates adenylate cyclase activity and intracellular cAMP levels. This protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response, and obesity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 2 family. response to hypoxia G-protein alpha-subunit binding transmembrane signaling receptor activity G-protein coupled receptor activity multivesicular body trans-Golgi network plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway memory feeding behavior visual learning hormone-mediated signaling pathway regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway corticotrophin-releasing factor receptor activity membrane integral component of membrane hypothalamus development dendrite epithelial cell differentiation intrinsic component of plasma membrane vesicle negative regulation of epinephrine secretion locomotory exploration behavior response to immobilization stress peptide binding neuronal cell body positive regulation of mast cell degranulation corticotropin-releasing hormone receptor activity positive regulation of cAMP-mediated signaling macromolecular complex binding apical part of cell behavioral response to cocaine regulation of synaptic plasticity behavioral response to pain corticotropin-releasing hormone binding response to electrical stimulus long-term synaptic potentiation cellular response to corticotropin-releasing hormone stimulus negative regulation of neuron death negative regulation of voltage-gated calcium channel activity negative regulation of feeding behavior uc007lvz.1 uc007lvz.2 uc007lvz.3 uc007lvz.4 
ENSMUST00000093935.3 Krtap31-1 ENSMUST00000093935.3 keratin associated protein 31-1 (from RefSeq NM_027568.3) ENSMUST00000093935.1 ENSMUST00000093935.2 Krtap31-1 NM_027568 Q9D644 Q9D644_MOUSE uc007ljw.1 uc007ljw.2 uc007ljw.3 molecular_function cellular_component intermediate filament biological_process keratin filament uc007ljw.1 uc007ljw.2 uc007ljw.3 
ENSMUST00000093936.5 Krtap9-1 ENSMUST00000093936.5 keratin associated protein 9-1 (from RefSeq NM_015741.2) ENSMUST00000093936.1 ENSMUST00000093936.2 ENSMUST00000093936.3 ENSMUST00000093936.4 Krtap9-1 NM_015741 Q64526 Q64526_MOUSE uc007ljv.1 uc007ljv.2 uc007ljv.3 uc007ljv.4 molecular_function cellular_component intermediate filament biological_process keratin filament uc007ljv.1 uc007ljv.2 uc007ljv.3 uc007ljv.4 
ENSMUST00000093938.10 Gsdma2 ENSMUST00000093938.10 gasdermin A2, transcript variant 1 (from RefSeq NM_029727.3) ENSMUST00000093938.1 ENSMUST00000093938.2 ENSMUST00000093938.3 ENSMUST00000093938.4 ENSMUST00000093938.5 ENSMUST00000093938.6 ENSMUST00000093938.7 ENSMUST00000093938.8 ENSMUST00000093938.9 GSDA2_MOUSE Gsdm2 Gsdma2 NM_029727 Q32M21 Q8CF01 Q9D810 uc007lgu.1 uc007lgu.2 uc007lgu.3 [Gasdermin-A2]: This form constitutes the precursor of the pore-forming protein and acts as a sensor of infection: upon bacterial infection, specifically cleaved by some bacterial effector protein, releasing the N-terminal moiety (Gasdermin-A2, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. [Gasdermin-A2, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage of Gasdermin-A2, and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)- bisphosphate. [Gasdermin-A2]: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C- terminal domains mediate autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-A2, N-terminal). [Gasdermin-A2, N-terminal]: Homooligomer; homooligomeric ring- shaped pore complex containing 18-36 subunits when inserted in the membrane. [Gasdermin-A2]: Cytoplasm, perinuclear region Cytoplasm, cytosol [Gasdermin-A2, N-terminal]: Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q32M21-1; Sequence=Displayed; Name=2 ; IsoId=Q32M21-2; Sequence=VSP_052880, VSP_052882; Name=3 ; IsoId=Q32M21-3; Sequence=VSP_052881; Expressed in the gastrointestinal tract, specifically from the middle to the upper region of the gastric mucosa in the glandular stomach. Expression is first detected at 16.6-17.5 dpc. Intramolecular interactions between N- and C-terminal domains are important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain. Cleavage relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-A2, N-terminal) that initiates pyroptosis (By similarity). In contrast to Gsdma, not cleaved by bacterial effector protein SpeB (PubMed:35110732). Mice lacking Gsdma, Gsdma2 and Gsdma3 are highly susceptible to subcutaneous group A Streptococcus (GAS) infection in an animal model. Belongs to the gasdermin family. phosphatidylserine binding phosphatidylinositol-4,5-bisphosphate binding cellular_component cytoplasm cytosol plasma membrane programmed cell death membrane perinuclear region of cytoplasm pyroptosis phosphatidylinositol-4-phosphate binding uc007lgu.1 uc007lgu.2 uc007lgu.3 
ENSMUST00000093939.4 Fbxo47 ENSMUST00000093939.4 F-box protein 47, transcript variant 5 (from RefSeq NM_001418109.1) A2A6H3 B2RY07 ENSMUST00000093939.1 ENSMUST00000093939.2 ENSMUST00000093939.3 FBX47_MOUSE NM_001418109 uc007lfb.1 uc007lfb.2 uc007lfb.3 Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. molecular_function cellular_component biological_process uc007lfb.1 uc007lfb.2 uc007lfb.3 
ENSMUST00000093942.5 Gpr179 ENSMUST00000093942.5 G protein-coupled receptor 179 (from RefSeq NM_001081220.2) E9PY61 ENSMUST00000093942.1 ENSMUST00000093942.2 ENSMUST00000093942.3 ENSMUST00000093942.4 GP179_MOUSE Gpr179 NM_001081220 Nob5 uc007ldy.1 uc007ldy.2 uc007ldy.3 Orphan receptor involved in vision (PubMed:22325362, PubMed:24114537, PubMed:24790204, PubMed:30282023). Required for signal transduction through retinal depolarizing bipolar cells (PubMed:22325362, PubMed:24114537, PubMed:24790204, PubMed:33922602). Acts as an atypical G-protein coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:22689652, PubMed:24790204). Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1 (PubMed:24114537, PubMed:24790204). Homodimer (PubMed:34333057). Associates with the R7 group RGS- GNB5 complexes, composed of an R7 group RGS subunit (RGS6, RGS7, RGS9 or RGS11) and GNB5, promoting their localization to the cell membrane and regulating the GTPase activator activity of R7 RGS proteins (PubMed:22689652). Interacts with TRPM1 (PubMed:24114537, PubMed:24790204). Interacts with GRM6 (PubMed:24114537). Interacts with EGFLAM; transsynaptic interaction is required for synaptic organization of photoreceptor cells (PubMed:30282023). Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Cell projection, dendrite Note=Specifically localizes to the tips of retinal ON-bipolar dendrites. Note=Defects in Gpr179 are the cause of nob5 (no b-wave 5), a spontaneous mutation that causes failure to transmit the photoreceptor signal through the depolarizing bipolar cells, characterized by an absence of the electroretinogram (ERG) b-wave (PubMed:22325362, PubMed:24415894, PubMed:24084093). In retina, rod and cone ON-bipolar cell function is absent (PubMed:22325362). Note=Defects in Pde6b are involved in the retinal degeneration 1 (rd1) allele, which causes retinal degeneration (PubMed:25613321). The rd1 allele is mainly caused by defects in the Pde6b gene, but it contains a cofounding mutation in the Gpr179 gene (PubMed:25613321). Mice display impaired night vision due to a failure to transmit the photoreceptor signal through the depolarizing bipolar cells (PubMed:33922602). Mice also show myopic features, probably caused by a decrease in both retinal dopamine and 3,4- dihydroxyphenylacetic acid (PubMed:36613663). Belongs to the G-protein coupled receptor 3 family. G-protein coupled receptor activity protein binding G-protein coupled receptor signaling pathway visual perception membrane integral component of membrane dendrite terminus protein localization to plasma membrane uc007ldy.1 uc007ldy.2 uc007ldy.3 
ENSMUST00000093943.10 Cbx1 ENSMUST00000093943.10 chromobox 1, transcript variant 1 (from RefSeq NM_007622.4) CBX1_MOUSE Cbx ENSMUST00000093943.1 ENSMUST00000093943.2 ENSMUST00000093943.3 ENSMUST00000093943.4 ENSMUST00000093943.5 ENSMUST00000093943.6 ENSMUST00000093943.7 ENSMUST00000093943.8 ENSMUST00000093943.9 NM_007622 P23197 P83917 uc007lcl.1 uc007lcl.2 uc007lcl.3 Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Homodimer (PubMed:10747027). Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain (PubMed:8978696, PubMed:10562550, PubMed:10747027). Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain (PubMed:11571267). Interacts with SUV39H1, SETDB1, KMT5B and KMT5C (PubMed:10202156, PubMed:15145825). Interacts with PRDM6 (PubMed:16537907). Interacts with POGZ (By similarity). Interacts with CHAMP1 (By similarity). Interacts with INCENP (By similarity). Interacts with SGO1; the CBX1 homodimer binds to one molecule of SGO1 (By similarity). Interacts with LRIF1 (via PxVxL motif) (By similarity). Interacts with HDGFL2 (By similarity). Interacts with CHD3 (By similarity). Interacts with CHD4 (By similarity). P83917; P83917: Cbx1; NbExp=3; IntAct=EBI-78119, EBI-78119; P83917; Q9QWF0: Chaf1a; NbExp=3; IntAct=EBI-78119, EBI-639217; P83917; P68433: H3c8; NbExp=6; IntAct=EBI-78119, EBI-79743; P83917; Q64127: Trim24; NbExp=4; IntAct=EBI-78119, EBI-307947; P83917; Q13263: TRIM28; Xeno; NbExp=2; IntAct=EBI-78119, EBI-78139; Nucleus Note=Unassociated with chromosomes during mitosis. In all adult and embryonic tissues. Not phosphorylated. Ubiquitinated. chromosome, centromeric region nuclear chromosome, telomeric region chromatin female pronucleus male pronucleus protein binding nucleus pericentric heterochromatin spindle cellular response to DNA damage stimulus chromocenter enzyme binding identical protein binding protein homodimerization activity negative regulation of transcription, DNA-templated histone methyltransferase binding uc007lcl.1 uc007lcl.2 uc007lcl.3 
ENSMUST00000093944.10 Hoxb3 ENSMUST00000093944.10 homeobox B3, transcript variant 1 (from RefSeq NM_001079869.1) ENSMUST00000093944.1 ENSMUST00000093944.2 ENSMUST00000093944.3 ENSMUST00000093944.4 ENSMUST00000093944.5 ENSMUST00000093944.6 ENSMUST00000093944.7 ENSMUST00000093944.8 ENSMUST00000093944.9 HXB3_MOUSE Hox-2.7 Hoxb-3 NM_001079869 P09026 P10285 Q4PJ06 Q61680 uc007lbw.1 uc007lbw.2 uc007lbw.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus. Belongs to the Antp homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding angiogenesis hematopoietic progenitor cell differentiation DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification rhombomere development glossopharyngeal nerve morphogenesis thyroid gland development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system morphogenesis regulation of neurogenesis cartilage development definitive hemopoiesis face development uc007lbw.1 uc007lbw.2 uc007lbw.3 
ENSMUST00000093955.12 Supt4a ENSMUST00000093955.12 SPT4A, DSIF elongation factor subunit, transcript variant 1 (from RefSeq NM_009296.2) B2KGH6 ENSMUST00000093955.1 ENSMUST00000093955.10 ENSMUST00000093955.11 ENSMUST00000093955.2 ENSMUST00000093955.3 ENSMUST00000093955.4 ENSMUST00000093955.5 ENSMUST00000093955.6 ENSMUST00000093955.7 ENSMUST00000093955.8 ENSMUST00000093955.9 NM_009296 P63271 Q16550 Q3TIA2 Q5NCP8 Q5NCP9 Q5NCQ0 Q62387 SPT4A_MOUSE Spt4h Supt4h Supt4h1a uc007kuj.1 uc007kuj.2 uc007kuj.3 Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity). Interacts with SUPT5H to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of WHSC2/NELFA, COBRA1/NELFB, TH1L/NELFD and RDBP/NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. DSIF also interacts with HRMT1L2/PRMT1, HTATSF1/TATSF1, RNGTT/CAP1A, SKB1/PRMT5, SUPT6H, and can interact with PIN1 (By similarity). Nucleus Widely expressed. Belongs to the SPT4 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core binding single-stranded RNA binding nucleus chromatin organization regulation of transcription, DNA-templated transcription elongation from RNA polymerase II promoter zinc ion binding DSIF complex negative regulation of DNA-templated transcription, elongation positive regulation of DNA-templated transcription, elongation negative regulation of transcription elongation from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter metal ion binding protein heterodimerization activity uc007kuj.1 uc007kuj.2 uc007kuj.3 
ENSMUST00000093956.4 Hsf5 ENSMUST00000093956.4 heat shock transcription factor family member 5 (from RefSeq NM_001045527.1) B2KGG8 ENSMUST00000093956.1 ENSMUST00000093956.2 ENSMUST00000093956.3 Gm739 HSF5_MOUSE NM_001045527 Q3TLD8 Q5ND04 uc007kuc.1 uc007kuc.2 May act as a transcriptional factor. Nucleus Expressed in adult but not fetal testis. Not expressed in ovary. Belongs to the HSF family. RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated cellular response to heat sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter in response to heat stress uc007kuc.1 uc007kuc.2 
ENSMUST00000093962.5 Ccnd1 ENSMUST00000093962.5 cyclin D1, transcript variant 2 (from RefSeq NM_007631.3) Ccnd1 ENSMUST00000093962.1 ENSMUST00000093962.2 ENSMUST00000093962.3 ENSMUST00000093962.4 NM_007631 Q790L7 Q790L7_MOUSE uc009kqt.1 uc009kqt.2 uc009kqt.3 Cytoplasm Nucleus membrane Belongs to the cyclin family. Cyclin D subfamily. G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter cyclin-dependent protein kinase holoenzyme complex liver development positive regulation of protein phosphorylation transcription corepressor activity nucleus nucleoplasm cytoplasm cellular response to DNA damage stimulus transcription factor binding positive regulation of cell proliferation response to organic substance response to iron ion response to X-ray response to organonitrogen compound positive regulation of G2/M transition of mitotic cell cycle response to organic cyclic compound transcriptional repressor complex enzyme binding protein kinase binding animal organ regeneration mitotic G1 DNA damage checkpoint response to magnesium ion response to estradiol response to vitamin E Leydig cell differentiation response to drug histone deacetylase binding response to estrogen response to leptin macromolecular complex binding response to ethanol positive regulation of cyclin-dependent protein serine/threonine kinase activity response to steroid hormone response to glucocorticoid response to corticosterone response to calcium ion proline-rich region binding response to UV-A negative regulation of cell cycle arrest uc009kqt.1 uc009kqt.2 uc009kqt.3 
ENSMUST00000093969.11 Myo19 ENSMUST00000093969.11 myosin XIX, transcript variant 1 (from RefSeq NM_025414.4) ENSMUST00000093969.1 ENSMUST00000093969.10 ENSMUST00000093969.2 ENSMUST00000093969.3 ENSMUST00000093969.4 ENSMUST00000093969.5 ENSMUST00000093969.6 ENSMUST00000093969.7 ENSMUST00000093969.8 ENSMUST00000093969.9 MYO19_MOUSE Myo19 Myohd1 NM_025414 Q5SV80 Q8BH54 Q9D2Z3 uc007krd.1 uc007krd.2 uc007krd.3 uc007krd.4 Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:24825904). Motor protein that moves towards the plus-end of actin filaments (PubMed:24825904). Required for mitochondrial inheritance during mitosis (By similarity). May be involved in mitochondrial transport or positioning (By similarity). Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin light chains MYL9 and MYL12B. Mitochondrion outer membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SV80-1; Sequence=Displayed; Name=2; IsoId=Q5SV80-2; Sequence=VSP_033407, VSP_033408; The MyMOMA (MYO19-specific mitochondrial outer membrane- association) region mediates association with the mitochondrion outer membrane via electrostatic interaction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. nucleotide binding motor activity actin binding ATP binding cytoplasm mitochondrion mitochondrial outer membrane cytosol cytoskeleton membrane myosin complex ATPase activity myosin light chain binding regulation of cytokinesis mitochondrion migration along actin filament plus-end directed microfilament motor activity regulation of mitochondrial fission uc007krd.1 uc007krd.2 uc007krd.3 uc007krd.4 
ENSMUST00000093971.5 Npnt ENSMUST00000093971.5 nephronectin, transcript variant 3 (from RefSeq NM_001287101.1) ENSMUST00000093971.1 ENSMUST00000093971.2 ENSMUST00000093971.3 ENSMUST00000093971.4 NM_001287101 NPNT_MOUSE Neph1 Poem Q6NV58 Q80VP6 Q91V88 Q91XL5 Q91ZD3 Q923T5 uc008rke.1 uc008rke.2 uc008rke.3 uc008rke.4 uc008rke.5 Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins. Homodimer and homotrimer. Secreted, extracellular space, extracellular matrix Note=Trapped on the cell surface or in the extracellular matrix. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Short; IsoId=Q91V88-1; Sequence=Displayed; Name=2; Synonyms=Long; IsoId=Q91V88-2; Sequence=VSP_026989; Name=3; IsoId=Q91V88-3; Sequence=VSP_026990; Name=4; IsoId=Q91V88-4; Sequence=VSP_026989, VSP_026990; Expressed in kidney (at protein level). Expressed from 10.5 dpc onward mainly at epithelial-mesenchymal interfaces in kidney and other tissues undergoing morphogenesis (at protein level). The MAM domain is required for localization at the cell surface. Mice display renal agenesis at birth due to a developmental delay. This delay is associated with a reduced expression of Gdnf and is similar to the one found in mice lacking Itga8. Was named nephronectin based on its potential role in kidney development. Belongs to the nephronectin family. ureteric bud development branching involved in ureteric bud morphogenesis integrin binding extracellular matrix structural constituent calcium ion binding extracellular region basement membrane extracellular space cell adhesion cell-matrix adhesion multicellular organism development positive regulation of alkaline phosphatase activity positive regulation of cell-substrate adhesion membrane cell differentiation extracellular matrix organization smooth muscle contractile fiber positive regulation of transforming growth factor beta receptor signaling pathway extracellular matrix cell-cell adhesion mediated by integrin establishment of protein localization positive regulation of osteoblast differentiation positive regulation of smooth muscle contraction positive regulation of ERK1 and ERK2 cascade cellular response to tumor necrosis factor pilomotor reflex positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation integrin alpha8-beta1 complex uc008rke.1 uc008rke.2 uc008rke.3 uc008rke.4 uc008rke.5 
ENSMUST00000093976.4 Arsj ENSMUST00000093976.4 arylsulfatase J (from RefSeq NM_173451.4) ARSJ_MOUSE ENSMUST00000093976.1 ENSMUST00000093976.2 ENSMUST00000093976.3 NM_173451 Q8BKG5 Q8BL46 Q8BM89 uc008rgc.1 uc008rgc.2 uc008rgc.3 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Secreted The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. Belongs to the sulfatase family. catalytic activity cellular_component extracellular region sulfuric ester hydrolase activity hydrolase activity metal ion binding uc008rgc.1 uc008rgc.2 uc008rgc.3 
ENSMUST00000093983.11 Evi2 ENSMUST00000093983.11 Evi2 (from geneSymbol) AK034440 ENSMUST00000093983.1 ENSMUST00000093983.10 ENSMUST00000093983.2 ENSMUST00000093983.3 ENSMUST00000093983.4 ENSMUST00000093983.5 ENSMUST00000093983.6 ENSMUST00000093983.7 ENSMUST00000093983.8 ENSMUST00000093983.9 Evi2 L7N211 L7N211_MOUSE uc033fyq.1 uc033fyq.2 uc033fyq.3 integral component of membrane uc033fyq.1 uc033fyq.2 uc033fyq.3 
ENSMUST00000093995.10 Sez6 ENSMUST00000093995.10 seizure related gene 6, transcript variant 1 (from RefSeq NM_021286.5) ENSMUST00000093995.1 ENSMUST00000093995.2 ENSMUST00000093995.3 ENSMUST00000093995.4 ENSMUST00000093995.5 ENSMUST00000093995.6 ENSMUST00000093995.7 ENSMUST00000093995.8 ENSMUST00000093995.9 Kiaa4158 NM_021286 Q3TT53 Q62223 Q62224 Q62269 Q7TPC9 Q7TSK2 SEZ6_MOUSE uc007khp.1 uc007khp.2 uc007khp.3 uc007khp.4 May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity. [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Note=Localized on dendrites and in the postsynaptic fraction. Does not appear to be enriched at synapses, at least not in the presynaptic axon terminal. [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Synapse. Cell projection, dendrite. Note=Localized on dendrites and in the synaptic and postsynaptic fraction. [Isoform 3]: Secreted Cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Type 2; IsoId=Q7TSK2-1; Sequence=Displayed; Name=2; Synonyms=Type 1; IsoId=Q7TSK2-2; Sequence=VSP_034256, VSP_034257; Name=3; Synonyms=Type 3; IsoId=Q7TSK2-3; Sequence=VSP_034254, VSP_034255; Brain-specific. Expressed in extrasynaptic and synaptic subcellular fractions (at protein level). Expression correlates with the most active periods of cortical neurogenesis and neuronal maturation. Expression is restricted to the gray matter with higher levels in the forebrain including the olfactory bulb, anterior olfactory nuclei, olfactory tubercle, striatum, hippocampal CA1 pyramidal cell layer and cerebral cortex. Expression is up-regulated with the convulsant drug, pentylenetetrazole. At 11.5 dpc, expression is localized to the preplate and is absent from the ventricular zone which is the most prominent layer during early cortical development. At 13 dpc highly expressed in postmitotic, maturing neurons of the developing cortical plate and subplate. At 15 dpc expression is closely tied with the emergence of the neocortical layers and hippocampus. In the cortex, expression diminishes after birth, but continues in the deep layer pyramidal neurons and neuronal subpopulations of layer II/III. In the hippocampus, expression persists in CA1 pyramidal neurons and in the dentate gyrus. Postnatally, expression remains high in specific cortical neuron populations, particularly those of the deep cortical layers. Glycosylated. Mice show reduced exploratory behavior and motor coordination, altered maze performance, and poorer memory retention. Molecular, morphological, and electrophysiological evidence of defects in dendritic arbor patterning was also seen. Secreted and membrane- bound isoforms in null mutants exerted opposite actions. The secreted isoform showed an increased neurite number, while, the membrane-bound isoform displayed a decrease in dendritic arborization. Embryos were viable, fertile and normal in other respects. Mice lacking Sez6, Sez6l1, Sez6l2 exhibited motor discordination, and Purkinje cells were often innervated by multiple climbing fibers with different neuronal origins in the cerebellum. Belongs to the SEZ6 family. Sequence=BAE36472.1; Type=Erroneous initiation; Evidence=; molecular_function extracellular region extracellular space cytoplasm endoplasmic reticulum plasma membrane adult locomotory behavior membrane integral component of membrane cerebellar Purkinje cell layer development cell junction dendrite cell projection neuronal cell body dendritic spine dendritic shaft synapse perinuclear region of cytoplasm regulation of dendrite development synapse maturation excitatory postsynaptic potential regulation of protein kinase C signaling apical dendrite positive regulation of dendrite development negative regulation of dendrite development uc007khp.1 uc007khp.2 uc007khp.3 uc007khp.4 
ENSMUST00000094002.10 D7Ertd443e ENSMUST00000094002.10 DNA segment, Chr 7, ERATO Doi 443, expressed, transcript variant 2 (from RefSeq NM_001081331.2) CJ090_MOUSE D2J0Y4 D7Ertd443e ENSMUST00000094002.1 ENSMUST00000094002.2 ENSMUST00000094002.3 ENSMUST00000094002.4 ENSMUST00000094002.5 ENSMUST00000094002.6 ENSMUST00000094002.7 ENSMUST00000094002.8 ENSMUST00000094002.9 Fats NM_001081331 uc009kds.1 uc009kds.2 uc009kds.3 Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage (PubMed:20843368, PubMed:20154723, PubMed:24240685). Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response (PubMed:24240685). Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (PubMed:20154723). May have a role in the assembly of primary cilia (By similarity). Interacts with HDAC1; the interaction prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (PubMed:20154723). Interacts with p53/TP53; the interaction inhibits binding of p53/TP53 and MDM2 (PubMed:24240685). Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin (By similarity). Highly expressed in testis. Weak expression found in brain, lung, heart, ovary, thymus, spleen and kidney. Upon DNA damage by agents such as ionizing radiation, UV and actinomycin D. Activated by p53/TP53. protein polyubiquitination protein binding nucleoplasm cytoplasm centrosome centriole microtubule organizing center cytosol cytoskeleton plasma membrane cellular response to DNA damage stimulus mitotic G2 DNA damage checkpoint microtubule binding response to UV response to ionizing radiation actin cytoskeleton protein ubiquitination transferase activity negative regulation of cell growth histone deacetylase binding regulation of centriole replication protein stabilization ubiquitin protein ligase activity uc009kds.1 uc009kds.2 uc009kds.3 
ENSMUST00000094004.5 Abhd15 ENSMUST00000094004.5 abhydrolase domain containing 15 (from RefSeq NM_026185.4) ABH15_MOUSE Abhd15 ENSMUST00000094004.1 ENSMUST00000094004.2 ENSMUST00000094004.3 ENSMUST00000094004.4 NM_026185 Q3V371 Q5F2F2 Q8C9I5 Q8CF57 Q9CU23 uc007kha.1 uc007kha.2 uc007kha.3 May regulate adipocyte lipolysis and liver lipid accumulation. Interacts with PDE3B; this interaction regulates PDE3B's stability and expression and, thereby, impacts the antilipolytic action of insulin. Secreted Mainly expressed in adipocytes and adipose depots, followed by a weak expression in liver and pancreas (PubMed:29768196). In white adipose tissue (WAT), only expressed in mature adipocytes and primary adipocytes differentiated from stromal vascular cells (SVCs), but not in undifferentiated SVCs (PubMed:29768196). Decreased by elevated free fatty acid levels and aging. Homozygous knockout mice lacking Abhd15 are fertile and newborn pups exhibit no obvious defects. Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. Sequence=BAB31349.1; Type=Frameshift; Evidence=; Sequence=BAC25102.1; Type=Frameshift; Evidence=; extracellular region hydrolase activity cellular lipid metabolic process uc007kha.1 uc007kha.2 uc007kha.3 
ENSMUST00000094014.10 Tlcd3a ENSMUST00000094014.10 TLC domain containing 3A, transcript variant 2 (from RefSeq NR_165039.1) ENSMUST00000094014.1 ENSMUST00000094014.2 ENSMUST00000094014.3 ENSMUST00000094014.4 ENSMUST00000094014.5 ENSMUST00000094014.6 ENSMUST00000094014.7 ENSMUST00000094014.8 ENSMUST00000094014.9 Fam57a NR_165039 Q5ND56 TLC3A_MOUSE uc007kfg.1 uc007kfg.2 uc007kfg.3 uc007kfg.4 Interacts with GGT7 isoform 3 and SLC3A2. Cell membrane ; Multi-pass membrane protein molecular_function plasma membrane biological_process membrane integral component of membrane uc007kfg.1 uc007kfg.2 uc007kfg.3 uc007kfg.4 
ENSMUST00000094018.6 Plpp4 ENSMUST00000094018.6 phospholipid phosphatase 4, transcript variant 7 (from RefSeq NM_001419391.1) ENSMUST00000094018.1 ENSMUST00000094018.2 ENSMUST00000094018.3 ENSMUST00000094018.4 ENSMUST00000094018.5 NM_001419391 PLPP4_MOUSE Plpp4 Q0VBU9 uc009jzl.1 uc009jzl.2 uc009jzl.3 Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol. Reaction=a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl- sn-glycero-3-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:27449, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608, ChEBI:CHEBI:59996; EC=3.6.1.75; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27450; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn- glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27430; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2- dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:42856, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:78229, ChEBI:CHEBI:82765; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42857; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctanoyl- sn-glycerol + phosphate; Xref=Rhea:RHEA:42860, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:76979, ChEBI:CHEBI:78229; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42861; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z- octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:39835, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:74544, ChEBI:CHEBI:75757; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39836; Evidence=; Magnesium-independent phospholipid phosphatase. Inhibited by N-ethylmaleimide. Lipid metabolism; phospholipid metabolism. Membrane ; Multi- pass membrane protein Belongs to the PA-phosphatase related phosphoesterase family. blastocyst hatching integral component of plasma membrane phospholipid metabolic process phosphatidate phosphatase activity membrane integral component of membrane hydrolase activity phosphatase activity identical protein binding phospholipid dephosphorylation uc009jzl.1 uc009jzl.2 uc009jzl.3 
ENSMUST00000094028.10 Capza1 ENSMUST00000094028.10 capping actin protein of muscle Z-line subunit alpha 1, transcript variant 1 (from RefSeq NM_009797.3) Capza1 ENSMUST00000094028.1 ENSMUST00000094028.2 ENSMUST00000094028.3 ENSMUST00000094028.4 ENSMUST00000094028.5 ENSMUST00000094028.6 ENSMUST00000094028.7 ENSMUST00000094028.8 ENSMUST00000094028.9 NM_009797 Q5RKN9 Q5RKN9_MOUSE uc008quq.1 uc008quq.2 uc008quq.3 uc008quq.4 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Heterodimer of an alpha and a beta subunit. Belongs to the F-actin-capping protein alpha subunit family. actin binding F-actin capping protein complex barbed-end actin filament capping actin filament capping uc008quq.1 uc008quq.2 uc008quq.3 uc008quq.4 
ENSMUST00000094037.5 Tbx6 ENSMUST00000094037.5 T-box 6 (from RefSeq NM_011538.2) B2RU37 ENSMUST00000094037.1 ENSMUST00000094037.2 ENSMUST00000094037.3 ENSMUST00000094037.4 NM_011538 P70327 Q5SDA2 TBX6_MOUSE uc009jsr.1 uc009jsr.2 uc009jsr.3 T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70327-1; Sequence=Displayed; Name=2; IsoId=P70327-2; Sequence=VSP_043221; TBX6 is first detected in the gastrulation stage in the primitive streak and newly recruited paraxial mesoderm. Later in development it is restricted to presomitic, paraxial mesoderm and to the tail bud, which replaces the streak as the source of mesoderm. Defects in the differentiation of paraxial mesoderm. Irregular somites formed in the neck region of mutant embryos, whereas more posterior paraxial tissue did not form somites but instead differentiated along a neural pathway, forming neural-tube- like structures that flanked the axial neural tube. These paraxial tubes showed dorsal/ventral patterning that is characteristic of the neural tube and had differentiated motor neurons. Embryos lacking TBX6 show also randomization of the direction of heart looping and independent alterations in the direction of embryo turning. Sequence=AAC53110.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding vasculogenesis mesoderm formation cell fate specification heart looping DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development negative regulation of neuron projection development negative regulation of neuron maturation signal transduction involved in regulation of gene expression somite rostral/caudal axis specification negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of transcription from RNA polymerase II promoter uc009jsr.1 uc009jsr.2 uc009jsr.3 
ENSMUST00000094051.6 Gm7324 ENSMUST00000094051.6 Gm7324 (from geneSymbol) A0A2I3BRL8 A0A2I3BRL8_MOUSE ENSMUST00000094051.1 ENSMUST00000094051.2 ENSMUST00000094051.3 ENSMUST00000094051.4 ENSMUST00000094051.5 Gm7324 LF199883 uc007tdc.1 uc007tdc.2 uc007tdc.3 nucleic acid binding RNA binding nucleus spliceosomal complex positive regulation of mRNA splicing, via spliceosome ribonucleoprotein complex uc007tdc.1 uc007tdc.2 uc007tdc.3 
ENSMUST00000094053.7 Tnrc6a ENSMUST00000094053.7 trinucleotide repeat containing 6a (from RefSeq NM_144925.3) ENSMUST00000094053.1 ENSMUST00000094053.2 ENSMUST00000094053.3 ENSMUST00000094053.4 ENSMUST00000094053.5 ENSMUST00000094053.6 F6ZMJ4 Kiaa1460 NM_144925 Q3UHK8 TNR6A_MOUSE uc009jpc.1 uc009jpc.2 uc009jpc.3 This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein is highly similar to a human protein that functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The human protein associates with messenger RNAs and argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies, and inhibiting its expression delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147327.1, SRR1660813.251091.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Plays a role in RNA-mediated gene silencing by both micro- RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:22187428). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:22187428). As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes (By similarity). Interacts with AGO2. Interacts with AGO1, AGO3 and AGO4. Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex. Interacts with ZC3H12A. Interacts with SND1. Interacts with GARRE1 (By similarity). Cytoplasm, P-body Note=Mammalian P-bodies are also known as GW bodies (GWBs). Detected in the yolk sac endoderm at embryonic stage 9.5 dpc. Development up until embryonic stage 9.5 dpc is normal. After this point, mortality rates increase rapidly with less than 5% survival at stage 12.5 dpc. The yolk sac endoderm is abnormally thin with fewer mitotic cells. In addition there are fewer blood islands in the yolk sac, associated with impaired hematopoiesis. Expression of many miRNA-regulated genes in the yolk sac is abnormal, and in particular there is marked derepression of genes involved in regulation of apoptosis and the cell cycle. miRNA biogenesis is not affected. Belongs to the GW182 family. P-body nucleic acid binding RNA binding nucleoplasm cytoplasm Golgi apparatus regulation of translation cellular response to starvation RISC complex gene silencing by RNA maintenance of protein location in cell gene silencing by miRNA miRNA mediated inhibition of translation intracellular membrane-bounded organelle perinuclear region of cytoplasm binding, bridging positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay uc009jpc.1 uc009jpc.2 uc009jpc.3 
ENSMUST00000094065.5 Tmem256 ENSMUST00000094065.5 transmembrane protein 256, transcript variant 1 (from RefSeq NM_026982.2) ENSMUST00000094065.1 ENSMUST00000094065.2 ENSMUST00000094065.3 ENSMUST00000094065.4 NM_026982 Q5F285 TM256_MOUSE uc007jry.1 uc007jry.2 uc007jry.3 Membrane ; Multi-pass membrane protein Belongs to the TMEM256 family. molecular_function mitochondrial inner membrane biological_process membrane integral component of membrane uc007jry.1 uc007jry.2 uc007jry.3 
ENSMUST00000094077.5 Kdm6b ENSMUST00000094077.5 KDM1 lysine (K)-specific demethylase 6B (from RefSeq NM_001017426.2) ENSMUST00000094077.1 ENSMUST00000094077.2 ENSMUST00000094077.3 ENSMUST00000094077.4 Jmjd3 KDM6B_MOUSE Kiaa0346 NM_001017426 Q3UWY9 Q4VC26 Q5NCY0 Q6ZQD3 uc007jqe.1 uc007jqe.2 uc007jqe.3 uc007jqe.4 Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T- box factors and the SMARCA4-containing SWI/SNF remodeling complex (PubMed:21095589). Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)- [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- lysyl(27)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60224, Rhea:RHEA-COMP:15535, Rhea:RHEA-COMP:15544, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961; EC=1.14.11.68; Evidence=; Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Interacts with TLE1 (PubMed:21095589). Component of the MLL4 complex, at least composed of KMT2B/MLL4, ASH2L, RBBP5, WDR5, and KDM6B (By similarity). Interacts with TBX21, SMARCA4, SMARCC1 and SMARCC2 (PubMed:21095589). Nucleus By inflammatory stimuli; mediated by NF-kappa-B. Belongs to the UTX family. Sequence=BAE22775.1; Type=Erroneous initiation; Evidence=; nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding chromatin binding protein binding nucleus chromatin organization chromatin remodeling inflammatory response beta-catenin binding regulation of gene expression oxidoreductase activity histone demethylation hippocampus development chromatin DNA binding sequence-specific DNA binding MLL3/4 complex cell fate commitment endothelial cell differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding mesodermal cell differentiation dioxygenase activity cardiac muscle cell differentiation oxidation-reduction process cellular response to hydrogen peroxide histone H3-K27 demethylation histone demethylase activity (H3-K27 specific) uc007jqe.1 uc007jqe.2 uc007jqe.3 uc007jqe.4 
ENSMUST00000094097.12 Tmem41b ENSMUST00000094097.12 transmembrane protein 41B (from RefSeq NM_153525.5) D7Ertd743e ENSMUST00000094097.1 ENSMUST00000094097.10 ENSMUST00000094097.11 ENSMUST00000094097.2 ENSMUST00000094097.3 ENSMUST00000094097.4 ENSMUST00000094097.5 ENSMUST00000094097.6 ENSMUST00000094097.7 ENSMUST00000094097.8 ENSMUST00000094097.9 Kiaa0033 NM_153525 Q3TKT0 Q3TLK6 Q8C1X2 Q8CBS5 Q8CBU5 Q8K1A5 TM41B_MOUSE Tmem41b uc009jep.1 uc009jep.2 uc009jep.3 Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Required for normal motor neuron development (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence=; Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747, ChEBI:CHEBI:16113; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2- diacyl-sn-glycero-3-phosphoethanolamine(out); Xref=Rhea:RHEA:38895, ChEBI:CHEBI:64612; Evidence=; Interacts with VMP1. Interacts with COPA, COPB1, VDAC1 and ERLIN2. Interacts with ATG2A. Interacts with SURF4. Endoplasmic reticulum membrane ; Multi-pass membrane protein Endomembrane system Note=Localized to specific membrane structures termed mitochondria- associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K1A5-1; Sequence=Displayed; Name=2; IsoId=Q8K1A5-2; Sequence=VSP_026319; Name=3; IsoId=Q8K1A5-3; Sequence=VSP_026318; Expressed in brain, spinal cord, kidney and first lumbar dorsal root ganglia during postnatal development. Expressed in motor neurons and proprioceptive neurons. The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain. Causes early embryonic lethality (PubMed:30352685). Conditional deletion in the liver leads to decreased number of circulating lipoproteins (PubMed:30352685). Belongs to the TMEM41 family. autophagosome assembly molecular_function endoplasmic reticulum endoplasmic reticulum membrane autophagy nervous system development membrane integral component of membrane uc009jep.1 uc009jep.2 uc009jep.3 
ENSMUST00000094103.4 Hs3st3b1 ENSMUST00000094103.4 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 (from RefSeq NM_018805.2) 3ost3b1 ENSMUST00000094103.1 ENSMUST00000094103.2 ENSMUST00000094103.3 HS3SB_MOUSE Hs3st3b NM_018805 Q5NCR0 Q9QZS6 uc007jkn.1 uc007jkn.2 uc007jkn.3 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike HS3ST1/3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:15461, Rhea:RHEA- COMP:9830, Rhea:RHEA-COMP:9831, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:70975; EC=2.8.2.30; Evidence=; Golgi apparatus membrane ; Single-pass type II membrane protein Belongs to the sulfotransferase 1 family. Golgi membrane Golgi apparatus integral component of plasma membrane protein sulfation sulfotransferase activity [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity membrane integral component of membrane transferase activity [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity uc007jkn.1 uc007jkn.2 uc007jkn.3 
ENSMUST00000094105.5 Or5p75-ps1 ENSMUST00000094105.5 Or5p75-ps1 (from geneSymbol) ENSMUST00000094105.1 ENSMUST00000094105.2 ENSMUST00000094105.3 ENSMUST00000094105.4 uc291uha.1 uc291uha.2 uc291uha.1 uc291uha.2 
ENSMUST00000094111.6 Cyp3a41a ENSMUST00000094111.6 cytochrome P450, family 3, subfamily a, polypeptide 41A (from RefSeq NM_017396.3) B2RQU5 CP341_MOUSE Cyp3a41 Cyp3a41b E9QJT9 ENSMUST00000094111.1 ENSMUST00000094111.2 ENSMUST00000094111.3 ENSMUST00000094111.4 ENSMUST00000094111.5 NM_017396 Q9JMA7 uc057lon.1 uc057lon.2 Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Expressed in liver. Also expressed in the kidneys of female mice, with traces in the stomach, ovary, and heart of female mice and in the testis of male mice. Detected immediately after birth in the livers of animals of both sexes, but increases with age in females, whereas it is gradually reduced in males, resulting in predominantly female-specific expression in livers. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cellular_component endoplasmic reticulum endoplasmic reticulum membrane steroid metabolic process steroid hydroxylase activity retinoic acid 4-hydroxylase activity response to bacterium regulation of gene expression membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding organelle membrane demethylase activity intracellular membrane-bounded organelle metal ion binding testosterone 6-beta-hydroxylase activity oxidation-reduction process aromatase activity oxidative demethylation estrogen 16-alpha-hydroxylase activity uc057lon.1 uc057lon.2 
ENSMUST00000094116.5 Zscan25 ENSMUST00000094116.5 zinc finger and SCAN domain containing 25, transcript variant 5 (from RefSeq NM_001384207.1) B2RX31 B2RX31_MOUSE ENSMUST00000094116.1 ENSMUST00000094116.2 ENSMUST00000094116.3 ENSMUST00000094116.4 NM_001384207 Zfp498 Zscan25 uc009amt.1 uc009amt.2 uc009amt.3 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009amt.1 uc009amt.2 uc009amt.3 
ENSMUST00000094124.5 Or51e1 ENSMUST00000094124.5 olfactory receptor family 51 subfamily E member 1 (from RefSeq NM_147093.3) ENSMUST00000094124.1 ENSMUST00000094124.2 ENSMUST00000094124.3 ENSMUST00000094124.4 NM_147093 Olfr558 Or51e1 Q8VGZ7 Q8VGZ7_MOUSE uc009isi.1 uc009isi.2 uc009isi.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AK141545.1, BB653241.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009isi.1 uc009isi.2 uc009isi.3 
ENSMUST00000094128.9 Art5 ENSMUST00000094128.9 ADP-ribosyltransferase 5, transcript variant 4 (from RefSeq NM_001411985.1) E9QM95 ENSMUST00000094128.1 ENSMUST00000094128.2 ENSMUST00000094128.3 ENSMUST00000094128.4 ENSMUST00000094128.5 ENSMUST00000094128.6 ENSMUST00000094128.7 ENSMUST00000094128.8 NAR5_MOUSE NM_001411985 P70352 Q91VF7 Q91X06 Q91X07 Q921A5 uc291tkw.1 uc291tkw.2 Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D- ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=2.4.2.31; Secreted. Membrane. Note=Membrane-associated. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P70352-1; Sequence=Displayed; Name=2; IsoId=P70352-2; Sequence=VSP_003380; Name=3; IsoId=P70352-3; Sequence=VSP_003381; Name=4; IsoId=P70352-4; Sequence=VSP_003382, VSP_003383; Abundantly expressed in testis. Lower levels in cardiac and skeletal muscle. Belongs to the Arg-specific ADP-ribosyltransferase family. NAD+ ADP-ribosyltransferase activity NAD(P)+-protein-arginine ADP-ribosyltransferase activity extracellular region protein ADP-ribosylation membrane transferase activity transferase activity, transferring glycosyl groups peptidyl-arginine ADP-ribosylation uc291tkw.1 uc291tkw.2 
ENSMUST00000094151.6 Rnf187 ENSMUST00000094151.6 ring finger protein 187 (from RefSeq NM_022423.2) A0A0J9YQM4 A0A0J9YQM4_MOUSE ENSMUST00000094151.1 ENSMUST00000094151.2 ENSMUST00000094151.3 ENSMUST00000094151.4 ENSMUST00000094151.5 NM_022423 Rnf187 uc007jcq.1 uc007jcq.2 uc007jcq.3 uc007jcq.4 metal ion binding uc007jcq.1 uc007jcq.2 uc007jcq.3 uc007jcq.4 
ENSMUST00000094154.6 Serpinh1 ENSMUST00000094154.6 serine (or cysteine) peptidase inhibitor, clade H, member 1, transcript variant 3 (from RefSeq NM_001111044.2) Cbp1 ENSMUST00000094154.1 ENSMUST00000094154.2 ENSMUST00000094154.3 ENSMUST00000094154.4 ENSMUST00000094154.5 Hsp47 NM_001111044 P19324 Q5U4D0 SERPH_MOUSE uc009ilm.1 uc009ilm.2 uc009ilm.3 uc009ilm.4 Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. Endoplasmic reticulum lumen. By heat shock and retinoic acid. Belongs to the serpin family. chondrocyte development involved in endochondral bone morphogenesis serine-type endopeptidase inhibitor activity protein binding collagen binding extracellular space cytoplasm endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum-Golgi intermediate compartment negative regulation of endopeptidase activity collagen fibril organization collagen biosynthetic process membrane raft unfolded protein binding protein maturation uc009ilm.1 uc009ilm.2 uc009ilm.3 uc009ilm.4 
ENSMUST00000094193.3 Meikin ENSMUST00000094193.3 meiotic kinetochore factor (from RefSeq NM_029105.2) ENSMUST00000094193.1 ENSMUST00000094193.2 MEIKN_MOUSE Meikin NM_029105 Q3KNB2 Q5F2C3 uc007ixv.1 uc007ixv.2 uc007ixv.3 uc007ixv.4 Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase- mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin- dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis. Interacts with CENPC. Interacts with PLK1; required for recruitment of PLK1 at kinetochores. Q5F2C3; P49452: Cenpc; NbExp=5; IntAct=EBI-20739301, EBI-1186252; Q5F2C3; Q07832: Plk1; NbExp=4; IntAct=EBI-20739301, EBI-2552999; Chromosome, centromere Chromosome, centromere, kinetochore Note=Localizes at kinetochores in meiosis I but undetectable in meiosis II. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5F2C3-1; Sequence=Displayed; Name=2; IsoId=Q5F2C3-2; Sequence=VSP_057509; Germ cell-specific. Expressed in both testis and ovary. Not expressed in other tissues. Appears at centromeres during the pachytene stage, when homologous chromosomes are synapsed. Peaks during diplotene stage, persists with gradual reduction until metaphase I, and disappears in anaphase I. Does not reappear on chromatin in meiosis II. Infertility due to defects in meiosis. Mice develop normally and show no visible phenotype but are completely infertile (both males and females) due to defects in meiotic chromosome segregation during meiosis I. Monooriented kinetochores split prematurely and sister chromosomes separate entirely before anaphase of meiosis II. chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed nuclear chromosome, centromeric region protein binding chromosome chromosome segregation male meiosis chromosome segregation meiotic sister chromatid cohesion involved in meiosis I female meiosis chromosome segregation homologous chromosome segregation meiotic cell cycle meiotic sister chromatid cohesion, centromeric uc007ixv.1 uc007ixv.2 uc007ixv.3 uc007ixv.4 
ENSMUST00000094203.11 Helz2 ENSMUST00000094203.11 Helz2 (from geneSymbol) A2AS03 A2AS03_MOUSE AB201714 BC006779 ENSMUST00000094203.1 ENSMUST00000094203.10 ENSMUST00000094203.2 ENSMUST00000094203.3 ENSMUST00000094203.4 ENSMUST00000094203.5 ENSMUST00000094203.6 ENSMUST00000094203.7 ENSMUST00000094203.8 ENSMUST00000094203.9 Helz2 uc290dme.1 uc290dme.2 RNA binding ribonuclease activity ligand-dependent nuclear receptor transcription coactivator activity RNA phosphodiester bond hydrolysis positive regulation of nucleic acid-templated transcription uc290dme.1 uc290dme.2 
ENSMUST00000094215.10 Mesd ENSMUST00000094215.10 mesoderm development LRP chaperone, transcript variant 1 (from RefSeq NM_023403.4) ENSMUST00000094215.1 ENSMUST00000094215.2 ENSMUST00000094215.3 ENSMUST00000094215.4 ENSMUST00000094215.5 ENSMUST00000094215.6 ENSMUST00000094215.7 ENSMUST00000094215.8 ENSMUST00000094215.9 MESD_MOUSE Mesd Mesdc2 NM_023403 Q8C611 Q8CCX7 Q91WK8 Q9CVB9 Q9ERE7 uc009idx.1 uc009idx.2 uc009idx.3 Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) (PubMed:31564437). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction (PubMed:12581525, PubMed:21397183). Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (PubMed:24140340). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells. Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP4; the interaction promotes glycosylation of LRP4 and its cell- surface expression (PubMed:24140340). Q9ERE7; Q8VI56: Lrp4; NbExp=2; IntAct=EBI-6662606, EBI-2106160; Q9ERE7; Q9ERE7: Mesd; NbExp=3; IntAct=EBI-6662606, EBI-6662606; Q9ERE7; O75581: LRP6; Xeno; NbExp=2; IntAct=EBI-6662606, EBI-910915; Endoplasmic reticulum Note=Released from apoptotic cells and shed photoreceptor outer segments (PubMed:27184668). Expressed in many tissues, but not in skeletal muscles (PubMed:11247670). In the retina expressed in retinal ganglion cells, inner and outer plexiform layers, photoreceptor inner and outer segments and retinal pigment epithelium (at protein level) (PubMed:27184668). The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6. The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding. Disruption of embryonic polarity and mesoderm differentiation, likely resulting from a primary defect in Wnt signaling. Belongs to the MESD family. Sequence=AAH14742.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC36476.1; Type=Frameshift; Evidence=; protein binding endoplasmic reticulum plasma membrane protein folding phagocytosis mesoderm development Wnt signaling pathway protein localization to cell surface identical protein binding low-density lipoprotein particle receptor binding positive regulation of skeletal muscle acetylcholine-gated channel clustering uc009idx.1 uc009idx.2 uc009idx.3 
ENSMUST00000094216.5 Tlnrd1 ENSMUST00000094216.5 talin rod domain containing 1 (from RefSeq NM_030705.4) ENSMUST00000094216.1 ENSMUST00000094216.2 ENSMUST00000094216.3 ENSMUST00000094216.4 Mesdc1 NM_030705 Q542D0 Q9ERE8 TLRN1_MOUSE Tlnrd1 uc009idw.1 uc009idw.2 uc009idw.3 Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. May homodimerize. Interacts with F-actin. Ubiquitous. actin binding biological_process stress fiber uc009idw.1 uc009idw.2 uc009idw.3 
ENSMUST00000094218.4 Slc17a9 ENSMUST00000094218.4 solute carrier family 17, member 9 (from RefSeq NM_183161.3) A2AJ51 ENSMUST00000094218.1 ENSMUST00000094218.2 ENSMUST00000094218.3 NM_183161 Q8VCL5 S17A9_MOUSE Slc17a9 uc008oka.1 uc008oka.2 uc008oka.3 Voltage-gated ATP nucleotide uniporter that can also transport the purine nucleotides ADP and GTP. Uses the membrane potential as the driving force to control ATP accumulation in lysosomes and secretory vesicles (PubMed:23876310, PubMed:24962569, PubMed:27477609). By controlling ATP storage in lysosomes, regulates ATP-dependent proteins of these organelles (PubMed:23832620, PubMed:24962569, PubMed:27477609). Also indirectly regulates the exocytosis of ATP through its import into lysosomes in astrocytes and secretory vesicles such as adrenal chromaffin granules, mucin granules and synaptic vesicles (By similarity). Reaction=ATP(in) = ATP(out); Xref=Rhea:RHEA:75687, ChEBI:CHEBI:30616; Evidence= Reaction=ADP(in) = ADP(out); Xref=Rhea:RHEA:75783, ChEBI:CHEBI:456216; Evidence=; Reaction=GTP(in) = GTP(out); Xref=Rhea:RHEA:75787, ChEBI:CHEBI:37565; Evidence=; Activity is chloride-dependent. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein Lysosome membrane ulti-pass membrane protein Note=Localizes to mucin granules and vesicles. In brain, specifically expressed in the medulla and is associated with chromaffin granules (at protein level). Predominantly expressed in adrenal gland, brain and thyroid. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. integral component of plasma membrane exocytosis membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008oka.1 uc008oka.2 uc008oka.3 
ENSMUST00000094226.2 Ccl26 ENSMUST00000094226.2 C-C motif chemokine ligand 26 (from RefSeq NM_001013412.2) Ccl26 ENSMUST00000094226.1 F8VQM2 F8VQM2_MOUSE NM_001013412 uc008zym.1 uc008zym.2 monocyte chemotaxis extracellular region extracellular space inflammatory response immune response G-protein coupled receptor signaling pathway chemokine activity neutrophil chemotaxis positive regulation of GTPase activity CCR chemokine receptor binding lymphocyte chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor uc008zym.1 uc008zym.2 
ENSMUST00000094227.10 Gm9696 ENSMUST00000094227.10 predicted gene 9696 (from RefSeq NR_037189.1) ENSMUST00000094227.1 ENSMUST00000094227.2 ENSMUST00000094227.3 ENSMUST00000094227.4 ENSMUST00000094227.5 ENSMUST00000094227.6 ENSMUST00000094227.7 ENSMUST00000094227.8 ENSMUST00000094227.9 NR_037189 uc008piy.1 uc008piy.2 uc008piy.3 uc008piy.1 uc008piy.2 uc008piy.3 
ENSMUST00000094245.4 Cldn3 ENSMUST00000094245.4 claudin 3 (from RefSeq NM_009902.4) CLD3_MOUSE Cpetr2 ENSMUST00000094245.1 ENSMUST00000094245.2 ENSMUST00000094245.3 NM_009902 Q91X40 Q9Z0G9 uc008zxe.1 uc008zxe.2 uc008zxe.3 uc008zxe.4 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a low-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein is highly overexpressed in uterine carcinosarcoma. This protein is also predominantly present in brain endothelial cells, where it plays a specific role in the establishment and maintenance of blood brain barrier tight junction morphology. [provided by RefSeq, Aug 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK002672.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. (Microbial infection) Interacts with Clostridium perfringens enterotoxin CPE; the interaction may disrupt claudin assembly in tight junctions. Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z0G9-1; Sequence=Displayed; Name=2; IsoId=Q9Z0G9-2; Sequence=VSP_001101; Expressed in the lung (PubMed:9892664, PubMed:24588076). Expressed at high levels in the liver and at lower levels, in kidney and testis (PubMed:9892664). Belongs to the claudin family. response to hypoxia epithelial cell morphogenesis structural molecule activity protein binding cytoplasm plasma membrane bicellular tight junction membrane integral component of membrane apicolateral plasma membrane lateral plasma membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding response to ethanol protein homooligomerization protein heterooligomerization occluding junction bicellular tight junction assembly regulation of membrane permeability positive regulation of bicellular tight junction assembly uc008zxe.1 uc008zxe.2 uc008zxe.3 uc008zxe.4 
ENSMUST00000094251.11 Fam217b ENSMUST00000094251.11 family with sequence similarity 217, member B (from RefSeq NM_001081289.1) 9030418K01Rik A2AJW5 A2AJW5_MOUSE ENSMUST00000094251.1 ENSMUST00000094251.10 ENSMUST00000094251.2 ENSMUST00000094251.3 ENSMUST00000094251.4 ENSMUST00000094251.5 ENSMUST00000094251.6 ENSMUST00000094251.7 ENSMUST00000094251.8 ENSMUST00000094251.9 Fam217b NM_001081289 uc008ohq.1 uc008ohq.2 uc008ohq.3 uc008ohq.4 molecular_function nucleoplasm cytosol biological_process uc008ohq.1 uc008ohq.2 uc008ohq.3 uc008ohq.4 
ENSMUST00000094280.4 Chchd2 ENSMUST00000094280.4 coiled-coil-helix-coiled-coil-helix domain containing 2 (from RefSeq NM_024166.6) CHCH2_MOUSE ENSMUST00000094280.1 ENSMUST00000094280.2 ENSMUST00000094280.3 NM_024166 Q3TUG8 Q9D1L0 uc008ztn.1 uc008ztn.2 uc008ztn.3 Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). Interacts with RBPJ. Nucleus Mitochondrion Mitochondrion intermembrane space Note=Mainly localized in the intermembrane space. nucleus mitochondrion mitochondrial intermembrane space mitochondrion organization transcription factor binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter regulation of cellular response to hypoxia uc008ztn.1 uc008ztn.2 uc008ztn.3 
ENSMUST00000094287.10 Ctcfl ENSMUST00000094287.10 CCCTC-binding factor like, transcript variant 1 (from RefSeq NM_001355185.1) A2APF3 B9EKP6 Boris CTCFL_MOUSE ENSMUST00000094287.1 ENSMUST00000094287.2 ENSMUST00000094287.3 ENSMUST00000094287.4 ENSMUST00000094287.5 ENSMUST00000094287.6 ENSMUST00000094287.7 ENSMUST00000094287.8 ENSMUST00000094287.9 NM_001355185 Q3Y6S0 uc008odi.1 uc008odi.2 Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. Interacts with histones, PRMT7 and SETD1A. Interacts (via N- terminus) with BAG6/BAT3 (By similarity). A2APF3; Q922X9: Prmt7; NbExp=3; IntAct=EBI-11566304, EBI-15606508; Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2APF3-1; Sequence=Displayed; Name=2; IsoId=A2APF3-2; Sequence=VSP_037281; Testis-specific. Not detected at 13.5 dpc. Detected in mitotically arrested gonocytes of 14.5 dpc embryos. From 17.5 dpc to newborn, it is expressed in some centrally located gonocytes and cells present at the periphery of the developing seminiferous tubules. Present in nuclei of spermatogonia from 15 days after birth to adulthood. Belongs to the CTCF zinc-finger protein family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding protein binding nucleus cytoplasm chromatin organization regulation of gene expression by genetic imprinting positive regulation of gene expression histone methylation histone binding DNA methylation involved in gamete generation sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding regulation of histone H3-K4 methylation uc008odi.1 uc008odi.2 
ENSMUST00000094288.10 Wdr64 ENSMUST00000094288.10 WD repeat domain 64 (from RefSeq NM_029453.2) E9QM22 E9QM22_MOUSE ENSMUST00000094288.1 ENSMUST00000094288.2 ENSMUST00000094288.3 ENSMUST00000094288.4 ENSMUST00000094288.5 ENSMUST00000094288.6 ENSMUST00000094288.7 ENSMUST00000094288.8 ENSMUST00000094288.9 NM_029453 Wdr64 uc011wxe.1 uc011wxe.2 uc011wxe.3 uc011wxe.1 uc011wxe.2 uc011wxe.3 
ENSMUST00000094303.6 Fcrl6 ENSMUST00000094303.6 Fc receptor-like 6 (from RefSeq NM_001164725.1) A1YIY0 E9QM04 ENSMUST00000094303.1 ENSMUST00000094303.2 ENSMUST00000094303.3 ENSMUST00000094303.4 ENSMUST00000094303.5 FCRL6_MOUSE NM_001164725 uc011wwo.1 uc011wwo.2 uc011wwo.3 Acts as a MHC class II receptor. When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells. Does not act as an Fc receptor. Interacts with class II MHC. Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A1YIY0-1; Sequence=Displayed; Name=2; IsoId=A1YIY0-2; Sequence=VSP_053295, VSP_053296; plasma membrane biological_process external side of plasma membrane membrane integral component of membrane phosphatase binding protein phosphatase binding MHC class II protein binding uc011wwo.1 uc011wwo.2 uc011wwo.3 
ENSMUST00000094320.11 Ccdc62 ENSMUST00000094320.11 coiled-coil domain containing 62 (from RefSeq NM_001134767.1) CCD62_MOUSE E9PVD1 ENSMUST00000094320.1 ENSMUST00000094320.10 ENSMUST00000094320.2 ENSMUST00000094320.3 ENSMUST00000094320.4 ENSMUST00000094320.5 ENSMUST00000094320.6 ENSMUST00000094320.7 ENSMUST00000094320.8 ENSMUST00000094320.9 F6WEA5 NM_001134767 uc290zsi.1 uc290zsi.2 uc290zsi.3 Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR (By similarity). Required for normal spermiogenesis (PubMed:28339613). It probably plays a role in acrosome formation (PubMed:28339613). Interacts with ESR1 and ESR2 in the presence of estradiol/E2. The interaction with ESR2 recruits CCDC62 to ER target genes, including cyclin-D1/CCND1 AP-1 promoter (By similarity). Interacts with GOPC (PubMed:28339613). Cytoplasm Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome Note=Mainly nuclear. Highly expressed in testis, not detected in other tissues (at protein level). Expressed at low levels in the epididymis, lung, spleen, bladder, kidney, liver, muscle. Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The first one is essential for the association with ESR1 and ESR2 (By similarity). blastocyst hatching nucleus nucleoplasm cytoplasm plasma membrane estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity positive regulation of transcription from RNA polymerase II promoter cellular response to estradiol stimulus uc290zsi.1 uc290zsi.2 uc290zsi.3 
ENSMUST00000094324.8 Cdc25a ENSMUST00000094324.8 cell division cycle 25A, transcript variant 1 (from RefSeq NM_007658.4) Cdc25m3 E9PVD0 ENSMUST00000094324.1 ENSMUST00000094324.2 ENSMUST00000094324.3 ENSMUST00000094324.4 ENSMUST00000094324.5 ENSMUST00000094324.6 ENSMUST00000094324.7 MPIP1_MOUSE NM_007658 P48964 uc009rsw.1 uc009rsw.2 uc009rsw.3 Tyrosine protein phosphatase which functions as a dosage- dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro (By similarity). Phosphorylation by PIM1 leads to an increase in phosphatase activity (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Stimulated by B-type cyclins. Stimulated by PIM1- mediated phosphorylation (By similarity). Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14-3-3 epsilon when phosphorylated. Interacts with CUL1 specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1 and FBXW11/BTRCP2. Interactions with CUL1, BTRC and FBXW11 are enhanced upon DNA damage. Interacts with PIM1. Interacts with CHEK2; mediates CDC25A phosphorylation and degradation in response to infrared-induced DNA damages (By similarity). Interacts with HSP90AB1; prevents heat shock- mediated CDC25A degradation and contributes to cell cycle progression (By similarity). Ubiquitously expressed in most developing tissue. High levels in the testis and lower levels in the ovary, particularly in germ cells. Lower levels also in kidney, liver, heart and muscle. First detected at the blastocyst stage. The phosphodegron motif mediates interaction with specific F- box proteins when phosphorylated. Putative phosphorylation sites at Ser-78 and Ser-81 appear to be essential for this interaction (By similarity). Phosphorylated by CHEK1 on Ser-75, Ser-123, Ser-172, Ser-271, Ser- 284 and Thr-497 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-123, Ser-271, and Ser-284 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-172 and Thr-497 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-75, Ser-123, Ser-172, Ser-271 and Ser- 284 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-75 by CHEK1 primes it for subsequent phosphorylation at Ser-75, Ser-81 and Ser-87 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation (By similarity). Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex that contains FZR1/CDH1 during G1 phase leading to its degradation by the proteasome. Ubiquitinated by a SCF complex containing BTRC and FBXW11 during S phase leading to its degradation by the proteasome. Deubiquitination by USP17L2/DUB3 leads to its stabilization (By similarity). Belongs to the MPI phosphatase family. G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm protein dephosphorylation cell cycle response to radiation positive regulation of G2/M transition of mitotic cell cycle hydrolase activity protein kinase binding cellular response to UV peptidyl-tyrosine dephosphorylation positive regulation of mitotic cell cycle chaperone binding cell division positive regulation of cell cycle G2/M phase transition uc009rsw.1 uc009rsw.2 uc009rsw.3 
ENSMUST00000094327.10 Lrrc43 ENSMUST00000094327.10 leucine rich repeat containing 43, transcript variant 1 (from RefSeq NM_001033461.3) ENSMUST00000094327.1 ENSMUST00000094327.2 ENSMUST00000094327.3 ENSMUST00000094327.4 ENSMUST00000094327.5 ENSMUST00000094327.6 ENSMUST00000094327.7 ENSMUST00000094327.8 ENSMUST00000094327.9 Gm1061 LRC43_MOUSE NM_001033461 Q3TIS6 Q3TJS5 Q3V0L5 uc008znu.1 uc008znu.2 uc008znu.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3V0L5-1; Sequence=Displayed; Name=2; IsoId=Q3V0L5-2; Sequence=VSP_029638; Sequence=BAE39420.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc008znu.1 uc008znu.2 uc008znu.3 
ENSMUST00000094329.11 Elmo2 ENSMUST00000094329.11 engulfment and cell motility 2, transcript variant 3 (from RefSeq NM_080287.2) A2A5A6 ELMO2_MOUSE ENSMUST00000094329.1 ENSMUST00000094329.10 ENSMUST00000094329.2 ENSMUST00000094329.3 ENSMUST00000094329.4 ENSMUST00000094329.5 ENSMUST00000094329.6 ENSMUST00000094329.7 ENSMUST00000094329.8 ENSMUST00000094329.9 Kiaa1834 NM_080287 Q5GMG3 Q8BHL5 Q8BHL9 Q8BQG1 Q8CBM8 Q8CC50 Q8CH98 Q91ZU2 Q9CT75 uc008nxl.1 uc008nxl.2 uc008nxl.3 Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3- binding site (PubMed:25533347). Probably forms a heterotrimeric complex with DOCK1 and RAC1. Interacts with ARHGEF16, DOCK4 and EPHA2; mediates activation of RAC1 by EPHA2 (By similarity). Interacts with ADGRB3 (By similarity). Interacts with AUTS2; the interaction is direct (PubMed:25533347). Cytoplasm Cytoplasm, cytosol Membrane Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BHL5-1; Sequence=Displayed; Name=2; IsoId=Q8BHL5-2; Sequence=VSP_007488; Name=3; IsoId=Q8BHL5-3; Sequence=VSP_007488, VSP_007489; cytoplasm cytosol phagocytosis apoptotic process cytoskeleton organization membrane cell migration SH3 domain binding receptor tyrosine kinase binding cell chemotaxis cell-cell adhesion uc008nxl.1 uc008nxl.2 uc008nxl.3 
ENSMUST00000094331.5 Nsmce3 ENSMUST00000094331.5 NSE3 homolog, SMC5-SMC6 complex component (from RefSeq NM_023239.5) ENSMUST00000094331.1 ENSMUST00000094331.2 ENSMUST00000094331.3 ENSMUST00000094331.4 Mageg1 NM_023239 NSE3_MOUSE Ndnl2 Q569V7 Q9CPR8 Q9D378 uc009hgm.1 uc009hgm.2 uc009hgm.3 Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl- conjugating enzyme (E2) at the E3:substrate complex (By similarity). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (PubMed:14593116). Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Interacts with PJA1 (By similarity). Interacts with E2F1 (via C-terminus) (PubMed:14593116). Interacts with NGFR (via C-terminus) (PubMed:14593116). Interacts with NSMCE1. Interacts with NSMCE4. Interacts with SMC6. Interacts with EID3 (By similarity). Q9CPR8; Q61501: E2f1; NbExp=5; IntAct=EBI-5529102, EBI-1025536; Q9CPR8; P08138: NGFR; Xeno; NbExp=3; IntAct=EBI-5529102, EBI-1387782; Cytoplasm Nucleus Chromosome, telomere Ubiquitous. chromosome, telomeric region protein binding nucleus chromosome cytoplasm DNA repair DNA recombination regulation of transcription, DNA-templated cellular response to DNA damage stimulus Smc5-Smc6 complex positive regulation of protein ubiquitination cellular response to UV regulation of growth protein dimerization activity cellular response to radiation cellular response to hydroxyurea uc009hgm.1 uc009hgm.2 uc009hgm.3 
ENSMUST00000094337.2 Fcrlb ENSMUST00000094337.2 Fc receptor-like B (from RefSeq NM_001029984.2) ENSMUST00000094337.1 F8VQL1 FCRLB_MOUSE Fcrl2 Fcrlm2 Fcry Freb2 NM_001029984 Q5DRQ8 uc007dmp.1 uc007dmp.2 Cytoplasm Endoplasmic reticulum Note=Seems not to be secreted. Expressed at low levels. Expressed in B- lymphocytes. Detected in spleen, lymph node, kidney, lung and brain. Up-regulated upon cell cycle arrest. molecular_function cytoplasm endoplasmic reticulum negative regulation of immune response uc007dmp.1 uc007dmp.2 
ENSMUST00000094339.3 Peg12 ENSMUST00000094339.3 paternally expressed 12 (from RefSeq NM_013788.2) ENSMUST00000094339.1 ENSMUST00000094339.2 Frat3 NM_013788 Peg12 Q9WVA7 Q9WVA7_MOUSE uc009hfj.1 uc009hfj.2 Belongs to the GSK-3-binding protein family. embryonic axis specification cytoplasm positive regulation of canonical Wnt signaling pathway Wnt signaling pathway uc009hfj.1 uc009hfj.2 
ENSMUST00000094340.4 Mkrn3 ENSMUST00000094340.4 makorin, ring finger protein, 3 (from RefSeq NM_011746.3) ENSMUST00000094340.1 ENSMUST00000094340.2 ENSMUST00000094340.3 MKRN3_MOUSE NM_011746 Q3UY92 Q60764 Q7TQE4 Zfp127 Znf127 uc009hfi.1 uc009hfi.2 E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Expressed in testis, brain, heart and kidney. Ubiquitously detected at low levels throughout the entire embryo, but expression is highest in the ventricular layers of the brain. Expressed at the blastocyst stage and the embryonic days 8-17, as well as in undifferentiated and differentiated embryonic stem cells. Expressed in the arcuate nucleus of both male and female animals. Levels of expression are highest on postnatal days 10 and 12, begin to decline on day 15, and reaches a nadir by days 18 to 22, at which time expression is 10 to 20% of the levels detected at 10 days. The timing of the decline in protein expression correlated with the ages at which arcuate KISS1 and TAC2 have been shown to increase, heralding the onset of puberty. Imprinted, expressed from the paternal chromosome only. The maternal methylation is established promptly after fertilization prior to syngamy. protein ubiquitination transferase activity identical protein binding metal ion binding uc009hfi.1 uc009hfi.2 
ENSMUST00000094344.6 Wfdc10 ENSMUST00000094344.6 WAP four-disulfide core domain 10 (from RefSeq NM_001039501.2) ENSMUST00000094344.1 ENSMUST00000094344.2 ENSMUST00000094344.3 ENSMUST00000094344.4 ENSMUST00000094344.5 NM_001039501 Q3V2J9 Q3V2J9_MOUSE Wfdc10 uc008nvo.1 uc008nvo.2 molecular_function cellular_component extracellular region biological_process negative regulation of peptidase activity peptidase inhibitor activity uc008nvo.1 uc008nvo.2 
ENSMUST00000094346.3 Wfdc6b ENSMUST00000094346.3 WAP four-disulfide core domain 6B (from RefSeq NM_001012725.3) B2RUM4 E9Q6A8 ENSMUST00000094346.1 ENSMUST00000094346.2 F6ULY1 NM_001012725 Q5DQU6 WFC6B_MOUSE Wfdc6 uc008nvl.1 uc008nvl.2 uc008nvl.3 uc008nvl.4 Secreted Sequence=AAI41217.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAT07038.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAM15023.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function serine-type endopeptidase inhibitor activity extracellular region extracellular space negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc008nvl.1 uc008nvl.2 uc008nvl.3 uc008nvl.4 
ENSMUST00000094348.4 Ccdc190 ENSMUST00000094348.4 coiled-coil domain containing 190, transcript variant 1 (from RefSeq NM_001033185.2) CC190_MOUSE ENSMUST00000094348.1 ENSMUST00000094348.2 ENSMUST00000094348.3 NM_001033185 Q3URK1 uc007dlo.1 uc007dlo.2 uc007dlo.3 It is uncertain whether Met-1 or Met-5 is the initiator. molecular_function cellular_component biological_process uc007dlo.1 uc007dlo.2 uc007dlo.3 
ENSMUST00000094357.11 Tmem116 ENSMUST00000094357.11 transmembrane protein 116, transcript variant 1 (from RefSeq NM_001161627.1) ENSMUST00000094357.1 ENSMUST00000094357.10 ENSMUST00000094357.2 ENSMUST00000094357.3 ENSMUST00000094357.4 ENSMUST00000094357.5 ENSMUST00000094357.6 ENSMUST00000094357.7 ENSMUST00000094357.8 ENSMUST00000094357.9 G3X9M9 G3X9M9_MOUSE NM_001161627 Tmem116 uc012ecv.1 uc012ecv.2 uc012ecv.3 Membrane ; Multi- pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc012ecv.1 uc012ecv.2 uc012ecv.3 
ENSMUST00000094361.11 Hsp90aa1 ENSMUST00000094361.11 heat shock protein 90, alpha (cytosolic), class A member 1 (from RefSeq NM_010480.5) ENSMUST00000094361.1 ENSMUST00000094361.10 ENSMUST00000094361.2 ENSMUST00000094361.3 ENSMUST00000094361.4 ENSMUST00000094361.5 ENSMUST00000094361.6 ENSMUST00000094361.7 ENSMUST00000094361.8 ENSMUST00000094361.9 Hsp90aa1 Hspca NM_010480 Q80Y52 Q80Y52_MOUSE uc007pbr.1 uc007pbr.2 uc007pbr.3 Cell membrane Melanosome Belongs to the heat shock protein 90 family. positive regulation of protein phosphorylation ATP binding nucleus cytoplasm protein folding telomere maintenance via telomerase response to heat response to cold ATPase activity nitric-oxide synthase regulator activity TPR domain binding regulation of protein ubiquitination ubiquitin protein ligase binding positive regulation of protein polymerization macromolecular complex identical protein binding protein homodimerization activity histone deacetylase binding protein import into mitochondrial outer membrane positive regulation of nitric oxide biosynthetic process response to antibiotic tau protein binding protein stabilization GTPase binding unfolded protein binding chaperone-mediated protein complex assembly positive regulation of telomerase activity DNA polymerase binding scaffold protein binding disordered domain specific binding positive regulation of tau-protein kinase activity positive regulation of cellular protein catabolic process telomerase holoenzyme complex assembly protein tyrosine kinase binding uc007pbr.1 uc007pbr.2 uc007pbr.3 
ENSMUST00000094378.10 Shc1 ENSMUST00000094378.10 src homology 2 domain-containing transforming protein C1, transcript variant 1 (from RefSeq NM_001113331.2) ENSMUST00000094378.1 ENSMUST00000094378.2 ENSMUST00000094378.3 ENSMUST00000094378.4 ENSMUST00000094378.5 ENSMUST00000094378.6 ENSMUST00000094378.7 ENSMUST00000094378.8 ENSMUST00000094378.9 NM_001113331 P98083 Q3U2Q7 Q8BFY3 Q8K4C6 Q8K4C7 SHC1_MOUSE Shc ShcA uc008pzn.1 uc008pzn.2 uc008pzn.3 uc008pzn.4 Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. Interacts with CPNE3; this interaction may mediate the binding of CPNE3 with ERBB2 (By similarity). Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated DDR2 and CD3T. Interacts with the N-terminal region of APS. Interacts with GRB7 and KIT (By similarity). Interacts with PTK2/FAK1 (By similarity). Interacts with phosphorylated LRP1 and IRS4. Interacts with FLT4 (tyrosine-phosphorylated) (By similarity). Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4 (By similarity). Interacts with TEK/TIE2 (tyrosine-phosphorylated) (By similarity). Interacts with ALK, GAB2, TRIM31, INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration. Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner. Interacts with CEACAM1; this interaction is CEACAM1-phosphorylation-dependent and mediates interaction with EGFR or INSR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity) (PubMed:15467833). Interacts (via PID domain) with PEAK1 (when phosphorylated at 'Tyr-1177') (By similarity). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (By similarity). P98083; P0DMN7: Amd1; NbExp=7; IntAct=EBI-300201, EBI-644529; P98083; Q60631: Grb2; NbExp=8; IntAct=EBI-300201, EBI-1688; P98083; Q9JKF1: Iqgap1; NbExp=5; IntAct=EBI-300201, EBI-644633; P98083; P35831: Ptpn12; NbExp=2; IntAct=EBI-300201, EBI-2642957; P98083; Q9Z179: Shcbp1; NbExp=5; IntAct=EBI-300201, EBI-644352; P98083-1; P98083-1: Shc1; NbExp=4; IntAct=EBI-7533258, EBI-7533258; P98083-1; Q62312: Tgfbr2; NbExp=2; IntAct=EBI-7533258, EBI-2899332; P98083-2; Q64729: Tgfbr1; NbExp=7; IntAct=EBI-1019301, EBI-2899393; P98083-2; Q62312: Tgfbr2; NbExp=3; IntAct=EBI-1019301, EBI-2899332; Cytoplasm Cell junction, focal adhesion [Isoform p47Shc]: Mitochondrion matrix Note=Targeting of isoform p47Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization (By similarity). [Isoform p66Shc]: Mitochondrion Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation. Event=Alternative splicing, Alternative initiation; Named isoforms=3; Comment=In human, it is alternative promoter usage that produces such isoforms.; Name=p66Shc; Synonyms=p66; IsoId=P98083-1; Sequence=Displayed; Name=p52Shc; Synonyms=p52; IsoId=P98083-2; Sequence=VSP_018791; Name=p47Shc; Synonyms=p47; IsoId=P98083-3; Sequence=VSP_018792; Widely expressed. Expressed in neural stem cells but absent in mature neurons. In response to a variety of growth factors, isoform p47Shc and isoform p52 bind to phosphorylated receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn- Pro-Xaa-Tyr(P) motif. Isoform p47Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline- rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation. Phosphorylated in response to FLT4 signaling (By similarity). Tyrosine phosphorylated by ligand-activated PDGFRB (By similarity). May be tyrosine phosphorylated by activated PTK2/FAK1 (By similarity). Tyrosine phosphorylated by TEK/TIE2 (By similarity). Tyrosine phosphorylated by activated PTK2B/PYK2 (By similarity). Dephosphorylation by PTPN2 may regulate interaction with GRB2 (By similarity). Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to KIT signaling. Isoform p47Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro- rich domain. Isoform p66Shc is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light. FLT3 signaling promotes tyrosine phosphorylation of isoform p47Shc and isoform p52Shc. Also tyrosine phosphorylated by ligand-activated ALK. [Isoform p52Shc]: Produced by alternative splicing. [Isoform p47Shc]: Produced by alternative initiation at Met-46 of isoform p52. MAPK cascade activation of MAPK activity angiogenesis phosphotyrosine binding epidermal growth factor receptor binding insulin receptor binding insulin-like growth factor receptor binding neurotrophin TRKA receptor binding protein binding nucleus cytoplasm mitochondrion mitochondrial matrix cytosol plasma membrane regulation of smooth muscle contraction signal transduction epidermal growth factor receptor signaling pathway heart development aging positive regulation of cell proliferation insulin receptor signaling pathway endosome membrane negative regulation of angiogenesis protein kinase binding actin cytoskeleton organization neuron differentiation receptor tyrosine kinase binding neuron projection development actin cytoskeleton reorganization intracellular signal transduction regulation of growth regulation of cell proliferation defense response to bacterium identical protein binding negative regulation of apoptotic process positive regulation of MAPK cascade macromolecular complex binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of vasoconstriction ephrin receptor binding epidermal growth factor binding positive regulation of smooth muscle cell proliferation phosphoprotein binding protein phosphatase 2A binding positive regulation of ERK1 and ERK2 cascade Shc-EGFR complex cellular response to growth factor stimulus positive regulation of cell proliferation in bone marrow regulation of superoxide metabolic process cell-cell adhesion response to endothelin uc008pzn.1 uc008pzn.2 uc008pzn.3 uc008pzn.4 
ENSMUST00000094383.3 Mrgprb3 ENSMUST00000094383.3 MAS-related GPR, member B3 (from RefSeq NM_207537.1) ENSMUST00000094383.1 ENSMUST00000094383.2 MRGB3_MOUSE Mrgb3 NM_207537 Q3B813 Q3B814 Q91ZC1 uc009hau.1 uc009hau.2 uc009hau.3 Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Mas subfamily. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009hau.1 uc009hau.2 uc009hau.3 
ENSMUST00000094384.4 Mrgprb1 ENSMUST00000094384.4 MAS-related GPR, member B1 (from RefSeq NM_205810.4) A4FUT5 A4QMY7 ENSMUST00000094384.1 ENSMUST00000094384.2 ENSMUST00000094384.3 MRGB1_MOUSE Mrgb1 NM_205810 Q3UFN5 Q3UFT1 Q3UFW7 Q3UFX0 Q3UFX7 Q3UFY5 Q3UG23 Q3UG61 Q3UG95 Q91ZC3 uc009hap.1 uc009hap.2 Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Mas subfamily. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane neuropeptide binding uc009hap.1 uc009hap.2 
ENSMUST00000094388.3 Mrgprb4 ENSMUST00000094388.3 MAS-related GPR, member B4 (from RefSeq NM_205795.1) ENSMUST00000094388.1 ENSMUST00000094388.2 MRGB4_MOUSE Mrgb4 NM_205795 Q3B811 Q91ZC0 uc009han.1 uc009han.2 uc009han.3 Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Mas subfamily. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009han.1 uc009han.2 uc009han.3 
ENSMUST00000094389.4 Mrgprb5 ENSMUST00000094389.4 MAS-related GPR, member B5 (from RefSeq NM_207538.1) ENSMUST00000094389.1 ENSMUST00000094389.2 ENSMUST00000094389.3 Mgrg11 Mrgprb5 NM_207538 W8W3Q3 W8W3Q3_MOUSE uc009ham.1 uc009ham.2 uc009ham.3 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009ham.1 uc009ham.2 uc009ham.3 
ENSMUST00000094390.3 Mrgprx1 ENSMUST00000094390.3 MAS-related GPR, member X1 (from RefSeq NM_207540.3) ENSMUST00000094390.1 ENSMUST00000094390.2 MRGX1_MOUSE Mrgc11 Mrgprc11 Mrgprx1 NM_207540 Q8CIP3 uc009hal.1 uc009hal.2 Orphan receptor activated by neuropeptides terminating in Arg-Phe or Arg-Phe-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception. Cell membrane; Multi-pass membrane protein Expressed in a subset of IB4-positive small diameter nociceptive dorsal root neurons. Belongs to the G-protein coupled receptor 1 family. Mas subfamily. hematopoietic progenitor cell differentiation G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway chemosensory behavior membrane integral component of membrane uc009hal.1 uc009hal.2 
ENSMUST00000094391.6 Iqcd ENSMUST00000094391.6 IQ motif containing D (from RefSeq NM_029408.3) DRC10_MOUSE Drc10 ENSMUST00000094391.1 ENSMUST00000094391.2 ENSMUST00000094391.3 ENSMUST00000094391.4 ENSMUST00000094391.5 NM_029408 Q497P6 Q8C5X0 Q9D3V1 uc008zho.1 uc008zho.2 uc008zho.3 Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Component of the nexin-dynein regulatory complex (N-DRC). Interacts with CFAP52 (By similarity). Cytoplasm, cytoskeleton, flagellum axoneme Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D3V1-1; Sequence=Displayed; Name=2; IsoId=Q9D3V1-2; Sequence=VSP_024181; Belongs to the DRC10 family. Sequence=BAC36556.1; Type=Frameshift; Evidence=; molecular_function cellular_component cytoplasm cytoskeleton cilium biological_process motile cilium cell projection uc008zho.1 uc008zho.2 uc008zho.3 
ENSMUST00000094398.13 Uevld ENSMUST00000094398.13 UEV and lactate/malate dehyrogenase domains (from RefSeq NM_001040695.1) Attp ENSMUST00000094398.1 ENSMUST00000094398.10 ENSMUST00000094398.11 ENSMUST00000094398.12 ENSMUST00000094398.2 ENSMUST00000094398.3 ENSMUST00000094398.4 ENSMUST00000094398.5 ENSMUST00000094398.6 ENSMUST00000094398.7 ENSMUST00000094398.8 ENSMUST00000094398.9 NM_001040695 O08761 Q3U1V6 Q7TQD3 UEVLD_MOUSE Uev3 uc009gzr.1 uc009gzr.2 uc009gzr.3 Possible negative regulator of polyubiquitination. Homodimer. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U1V6-1; Sequence=Displayed; Name=2; IsoId=Q3U1V6-2; Sequence=VSP_023352, VSP_023353; In the N-terminal section; belongs to the ubiquitin- conjugating enzyme family. UEV subfamily. In the C-terminal section; belongs to the LDH/MDH superfamily. Sequence=AAB57699.1; Type=Frameshift; Evidence=; catalytic activity carbohydrate metabolic process cellular protein modification process protein transport oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor carboxylic acid metabolic process oxidation-reduction process uc009gzr.1 uc009gzr.2 uc009gzr.3 
ENSMUST00000094421.11 Cep250 ENSMUST00000094421.11 centrosomal protein 250, transcript variant 2 (from RefSeq NM_177217.3) CP250_MOUSE Cep2 E9QMB2 ENSMUST00000094421.1 ENSMUST00000094421.10 ENSMUST00000094421.2 ENSMUST00000094421.3 ENSMUST00000094421.4 ENSMUST00000094421.5 ENSMUST00000094421.6 ENSMUST00000094421.7 ENSMUST00000094421.8 ENSMUST00000094421.9 Inmp NM_177217 Q2I8G3 Q3UTR4 Q60952 Q6PFF6 Q8BLC6 uc012chh.1 uc012chh.2 May be involved in ciliogenesis. Probably plays an important role in centrosome cohesion during interphase. Monomer and homodimer (Probable). Forms a complex in vitro with both NEK2 kinase and the PPP1CC catalytic subunit of protein phosphatase 1 (PP1) (By similarity). Interacts with CEP135 (By similarity). Interacts with CROCC/rootletin (PubMed:16339073). Interacts with CNTLN (By similarity). Interacts with NIN (via C- terminus) (PubMed:27565344). Cytoplasm, perinuclear region Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body Cell projection, cilium, photoreceptor outer segment Photoreceptor inner segment Note=Component of the core centrosome where it is found at the proximal ends of centrioles. Expressed in the retina. C-terminal part is phosphorylated by NEK2. Dephosphorylated in vitro by the PP1 phosphatase (By similarity). Sequence=AAB41824.1; Type=Frameshift; Evidence=; mitotic cell cycle photoreceptor outer segment photoreceptor inner segment cytoplasm centrosome centriole cytoskeleton cilium cell cycle protein C-terminus binding protein localization centriole-centriole cohesion protein kinase binding protein domain specific binding cell projection organization regulation of centriole-centriole cohesion spindle pole centrosome macromolecular complex protein localization to organelle ciliary basal body cell projection perinuclear region of cytoplasm detection of light stimulus involved in visual perception cilium assembly positive regulation of protein localization to centrosome non-motile cilium assembly uc012chh.1 uc012chh.2 
ENSMUST00000094424.7 Spaca4 ENSMUST00000094424.7 sperm acrosome associated 4 (from RefSeq NM_027055.3) ENSMUST00000094424.1 ENSMUST00000094424.2 ENSMUST00000094424.3 ENSMUST00000094424.4 ENSMUST00000094424.5 ENSMUST00000094424.6 NM_027055 Q80ZQ0 Q9DAK7 SACA4_MOUSE Spaca4 uc009gwz.1 uc009gwz.2 uc009gwz.3 uc009gwz.4 Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Cell membrane ; Lipid-anchor, GPI-anchor Cytoplasmic vesicle, secretory vesicle, acrosome Note=Expressed in acrosomal matrix and outer and inner acrosomal membranes. Belongs to the SPACA4/bouncer family. acrosomal vesicle plasma membrane cell adhesion membrane anchored component of membrane cytoplasmic vesicle uc009gwz.1 uc009gwz.2 uc009gwz.3 uc009gwz.4 
ENSMUST00000094434.13 Ftl1 ENSMUST00000094434.13 ferritin light polypeptide 1 (from RefSeq NM_010240.2) ENSMUST00000094434.1 ENSMUST00000094434.10 ENSMUST00000094434.11 ENSMUST00000094434.12 ENSMUST00000094434.2 ENSMUST00000094434.3 ENSMUST00000094434.4 ENSMUST00000094434.5 ENSMUST00000094434.6 ENSMUST00000094434.7 ENSMUST00000094434.8 ENSMUST00000094434.9 Ftl1 Ftl1-ps1 NM_010240 Q9CPX4 Q9CPX4_MOUSE uc009gvf.1 uc009gvf.2 uc009gvf.3 Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Belongs to the ferritin family. cell iron ion transport cellular iron ion homeostasis ferric iron binding metal ion binding uc009gvf.1 uc009gvf.2 uc009gvf.3 
ENSMUST00000094438.2 Hes3 ENSMUST00000094438.2 hes family bHLH transcription factor 3 (from RefSeq NM_008237.5) ENSMUST00000094438.1 HES3_MOUSE Hes-3 NM_008237 O09083 O09150 Q61657 Q8BTI2 uc008wac.1 uc008wac.2 Transcriptional repressor of genes that require a bHLH protein for their transcription. Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Nucleus. Has a particular type of basic domain (presence of a helix- interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG). The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy- related proteins. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development DNA binding nucleus regulation of transcription, DNA-templated transcription factor binding anterior/posterior pattern specification midbrain-hindbrain boundary morphogenesis oculomotor nerve development trochlear nerve development hindbrain morphogenesis neural tube development cell differentiation midbrain development negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity regulation of neurogenesis regulation of timing of neuron differentiation uc008wac.1 uc008wac.2 
ENSMUST00000094441.11 Tchp ENSMUST00000094441.11 trichoplein, keratin filament binding (from RefSeq NM_029992.2) ENSMUST00000094441.1 ENSMUST00000094441.10 ENSMUST00000094441.2 ENSMUST00000094441.3 ENSMUST00000094441.4 ENSMUST00000094441.5 ENSMUST00000094441.6 ENSMUST00000094441.7 ENSMUST00000094441.8 ENSMUST00000094441.9 NM_029992 Q3TVW5 Q80ZV6 Q8C459 Q9CTP0 TCHP_MOUSE Tchp uc008yzx.1 uc008yzx.2 uc008yzx.3 Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18. Interacts with KCTD17 (By similarity). Cytoplasm, cytoskeleton Cytoplasm Cell membrane Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q3TVW5-1; Sequence=Displayed; Name=2 ; IsoId=Q3TVW5-2; Sequence=VSP_052475; Expressed in all tissues examined, including brain, liver, small intestine, large intestine, lung and heart. Found concentrated in tubular structures within hepatocytes, and in the apical cortical region and desmosomes of the apical junctional domain in enterocytes of the small intestine. In the hair follicle, localized at the outer root sheath. Also expressed in blood vessels (at protein level). Ubiquitinated. Ubiquitination by the BCR(KCTD17) E3 ubiquitin ligase complex results in proteasomal degradation, and induces ciliogenesis. Belongs to the TCHP family. Sequence=AAH47930.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cytoplasm mitochondrion centrosome cytosol cytoskeleton plasma membrane apoptotic process membrane cell projection organization desmosome negative regulation of cell growth keratin filament apical cortex ciliary transition fiber negative regulation of cilium assembly uc008yzx.1 uc008yzx.2 uc008yzx.3 
ENSMUST00000094451.4 Gpr157 ENSMUST00000094451.4 G protein-coupled receptor 157 (from RefSeq NM_177366.3) ENSMUST00000094451.1 ENSMUST00000094451.2 ENSMUST00000094451.3 GP157_MOUSE NM_177366 Q8C206 Q8C224 uc008vxj.1 uc008vxj.2 uc008vxj.3 Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs) (PubMed:27142930). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger (PubMed:27142930). Cell projection, cilium membrane ; Multi-pass membrane protein Note=Expressed in the primary cilia of radial glial progenitors (RGPs) exposed to the cerebrospinal fluid. Expressed in the primary cilia of radial glial progenitors (RGPs) in the developing neocortex (PubMed:27142930). Preferential expression during the early to mid stages of corticogenesis. High levels in the early radial glial progenitors from 10 to 17 dpc and gradually decrease thereafter (at protein level) (PubMed:27142930). Belongs to the G-protein coupled receptor 2 family. transmembrane signaling receptor activity G-protein coupled receptor activity plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway multicellular organism development membrane integral component of membrane cell differentiation cell projection circadian behavior positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway radial glial cell differentiation ciliary membrane uc008vxj.1 uc008vxj.2 uc008vxj.3 
ENSMUST00000094452.4 Wscd2 ENSMUST00000094452.4 WSC domain containing 2 (from RefSeq NM_177292.3) D4PHA7 ENSMUST00000094452.1 ENSMUST00000094452.2 ENSMUST00000094452.3 Kiaa0789 NM_177292 Q69ZZ2 Q8C7Q3 WSCD2_MOUSE uc057lnh.1 uc057lnh.2 Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. Golgi apparatus membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=D4PHA7-1; Sequence=Displayed; Name=2; IsoId=D4PHA7-2; Sequence=VSP_042508, VSP_042509; [Isoform 2]: May be due to an intron retention. Belongs to the WSCD family. Sequence=BAD32304.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc057lnh.1 uc057lnh.2 
ENSMUST00000094463.5 Mn1 ENSMUST00000094463.5 meningioma 1 (from RefSeq NM_001081235.3) D3YWE6 ENSMUST00000094463.1 ENSMUST00000094463.2 ENSMUST00000094463.3 ENSMUST00000094463.4 MN1_MOUSE Mn1 NM_001081235 uc008yse.1 uc008yse.2 uc008yse.3 Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate (PubMed:18948418). Required during later stages of palate development for normal growth and medial fusion of the palatal shelves (PubMed:18948418). Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL (PubMed:19386590). Necessary for normal development of the membranous bones of the skull (PubMed:15870292). May play a role in tumor suppression (By similarity). Interacts with PBX1, PKNOX1, ZBTB24, E2F7, RING1. Nucleus Detected in brain, heart, tibia, and calvarial osteoclasts. Detected in the midbrain, hindbrain and craniofacial mesenchyme at 9.5 dpc. At 10.5 dpc and 11.5 dpc, strong expression is detected in the brain, frontonasal processes, maxillary processes, mandibular processes, the second brachial arch, and also in somites and limb buds. In the developing palatal shelves from 12.5 dpc- 14.5 dpc, shows graded expression with highest levels in the posterior and middle regions and very low levels in the anterior region. By calcitrol (1,25-dihydroxyvitamin D3). Lethality occurs at or shortly after birth, associated with cleft secondary palate (PubMed:15870292). Skulls at late embryonic stages show multiple abnormalities including complete loss of alisphenoid, squamosal and vomer bones, and poorly developed presphenoid and basisphenoid bones (PubMed:15870292). Other parts of the skeleton are not affected (PubMed:15870292). Early palate development is normal but later the palatal shelves fail to grow and elevate towards the midline, associated with both impaired cell division and apoptosis (PubMed:18948418). intramembranous ossification regulation of transcription, DNA-templated multicellular organism development uc008yse.1 uc008yse.2 uc008yse.3 
ENSMUST00000094467.6 Entpd6 ENSMUST00000094467.6 ectonucleoside triphosphate diphosphohydrolase 6, transcript variant 1 (from RefSeq NM_172117.5) Cd39l2 ENSMUST00000094467.1 ENSMUST00000094467.2 ENSMUST00000094467.3 ENSMUST00000094467.4 ENSMUST00000094467.5 ENTP6_MOUSE Entpd6 NM_172117 Q3U0P5 uc012cfv.1 uc012cfv.2 uc012cfv.3 Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP. The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Reaction=a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'- phosphate + H(+) + phosphate; Xref=Rhea:RHEA:36799, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:58043; EC=3.6.1.6; Evidence=; Reaction=H2O + IDP = H(+) + IMP + phosphate; Xref=Rhea:RHEA:35207, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58053, ChEBI:CHEBI:58280; EC=3.6.1.6; Evidence=; Reaction=GDP + H2O = GMP + H(+) + phosphate; Xref=Rhea:RHEA:22156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189; EC=3.6.1.6; Evidence=; Reaction=H2O + UDP = H(+) + phosphate + UMP; Xref=Rhea:RHEA:64876, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57865, ChEBI:CHEBI:58223; EC=3.6.1.6; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Strongly and equally activated by either Ca(2+) or Mg(2+). ; Golgi apparatus membrane ; Single-pass type II membrane protein Secreted Cell membrane ; Single-pass type II membrane protein Note=Exists as a secreted and membrane-bound forms in the medium of transfected cells, the secreted form is predominant. N-glycosylated. Belongs to the GDA1/CD39 NTPase family. extracellular space Golgi apparatus plasma membrane guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity cell surface membrane integral component of membrane hydrolase activity nucleoside-diphosphatase activity nucleoside-triphosphatase activity response to magnesium ion response to calcium ion uc012cfv.1 uc012cfv.2 uc012cfv.3 
ENSMUST00000094469.6 Selenom ENSMUST00000094469.6 selenoprotein M (from RefSeq NM_053267.3) B2RVS9 ENSMUST00000094469.1 ENSMUST00000094469.2 ENSMUST00000094469.3 ENSMUST00000094469.4 ENSMUST00000094469.5 NM_053267 Q3V374 Q8CBT7 Q8VCJ0 Q8VHC3 SELM_MOUSE Selenom uc007htd.1 uc007htd.2 uc007htd.3 The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]. ##Evidence-Data-START## Transcript exon combination :: BQ939285.1, AK018791.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 11839807 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation. Cytoplasm, perinuclear region Endoplasmic reticulum Golgi apparatus Note=Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum. Widely expressed. Highly expressed in brain. Belongs to the selenoprotein M/F family. Sequence=AAH19742.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; molecular_function cytoplasm endoplasmic reticulum Golgi apparatus response to selenium ion multicellular organism growth corticosterone secretion hormone metabolic process perinuclear region of cytoplasm adipose tissue development uc007htd.1 uc007htd.2 uc007htd.3 
ENSMUST00000094481.2 Fv1 ENSMUST00000094481.2 Friend virus susceptibility 1 (from RefSeq NM_010244.3) ENSMUST00000094481.1 FV1_MOUSE NM_010244 P70213 P70214 uc008vtf.1 uc008vtf.2 Retroviral restriction factor that prevents infection by gammaretroviruses. Acts by interacting with the capsid protein ca after entry of the virus into the cell. This interaction presumably disrupt the capsid thereby inactivating the viral genome, making it unable to enter host nucleus and integrate into host genome. Golgi apparatus response to virus viral process defense response to virus uc008vtf.1 uc008vtf.2 
ENSMUST00000094491.5 Vmn2r121 ENSMUST00000094491.5 vomeronasal 2, receptor 121 (from RefSeq NM_001100616.1) A2BE32 A2BE32_MOUSE ENSMUST00000094491.1 ENSMUST00000094491.2 ENSMUST00000094491.3 ENSMUST00000094491.4 NM_001100616 Vmn2r121 uc009uep.1 uc009uep.2 uc009uep.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009uep.1 uc009uep.2 uc009uep.3 
ENSMUST00000094502.6 Vmn2r84 ENSMUST00000094502.6 vomeronasal 2, receptor 84 (from RefSeq NM_001081448.1) D3YWE3 D3YWE3_MOUSE ENSMUST00000094502.1 ENSMUST00000094502.2 ENSMUST00000094502.3 ENSMUST00000094502.4 ENSMUST00000094502.5 NM_001081448 Vmn2r84 uc007hrn.1 uc007hrn.2 uc007hrn.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc007hrn.1 uc007hrn.2 uc007hrn.3 
ENSMUST00000094510.4 Aadacl4 ENSMUST00000094510.4 arylacetamide deacetylase like 4 (from RefSeq NM_001081248.1) Aadacl4 B1AVU5 B1AVU5_MOUSE ENSMUST00000094510.1 ENSMUST00000094510.2 ENSMUST00000094510.3 NM_001081248 uc008vrj.1 uc008vrj.2 cellular_component catabolic process membrane integral component of membrane hydrolase activity short-chain carboxylesterase activity uc008vrj.1 uc008vrj.2 
ENSMUST00000094521.8 Gm13040 ENSMUST00000094521.8 predicted gene 13040 (from RefSeq NM_001113736.2) ENSMUST00000094521.1 ENSMUST00000094521.2 ENSMUST00000094521.3 ENSMUST00000094521.4 ENSMUST00000094521.5 ENSMUST00000094521.6 ENSMUST00000094521.7 Gm13040 Gm13043 Gm13057 NM_001113736 OTTMUSG00000010136 Q4FZF9 Q4FZF9_MOUSE uc290rmd.1 uc290rmd.2 uc290rmd.3 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290rmd.1 uc290rmd.2 uc290rmd.3 
ENSMUST00000094522.8 Pramel27 ENSMUST00000094522.8 PRAME like 27 (from RefSeq NM_177571.3) ENSMUST00000094522.1 ENSMUST00000094522.2 ENSMUST00000094522.3 ENSMUST00000094522.4 ENSMUST00000094522.5 ENSMUST00000094522.6 ENSMUST00000094522.7 Gm13103 NM_177571 OTTMUSG00000010433 Pramel27 Q4VAD2 Q4VAD2_MOUSE uc008vqo.1 uc008vqo.2 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vqo.1 uc008vqo.2 
ENSMUST00000094526.5 Pramel31 ENSMUST00000094526.5 PRAME like 31 (from RefSeq NM_001034101.2) B1ARV5 B1ARV5_MOUSE ENSMUST00000094526.1 ENSMUST00000094526.2 ENSMUST00000094526.3 ENSMUST00000094526.4 NM_001034101 Pramel31 uc008vrc.1 uc008vrc.2 uc008vrc.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vrc.1 uc008vrc.2 uc008vrc.3 
ENSMUST00000094532.4 Gm20449 ENSMUST00000094532.4 Gm20449 (from geneSymbol) AK084934 AW146154 E9Q3U2 E9Q3U2_MOUSE ENSMUST00000094532.1 ENSMUST00000094532.2 ENSMUST00000094532.3 Gm20449 uc291ovn.1 uc291ovn.2 uc291ovn.1 uc291ovn.2 
ENSMUST00000094544.3 Srarp ENSMUST00000094544.3 steroid receptor associated and regulated protein (from RefSeq NM_001033374.3) ENSMUST00000094544.1 ENSMUST00000094544.2 NM_001033374 Q3ULG3 SRARP_MOUSE Srarp uc008vok.1 uc008vok.2 uc008vok.3 May regulate the transcriptional function of androgen and estrogen receptors. Interacts with 14-3-3 proteins. nucleus cytoplasm estrogen receptor binding positive regulation of intracellular estrogen receptor signaling pathway uc008vok.1 uc008vok.2 uc008vok.3 
ENSMUST00000094556.3 Ren1 ENSMUST00000094556.3 renin 1 structural (from RefSeq NM_031192.3) ENSMUST00000094556.1 ENSMUST00000094556.2 NM_031192 P06281 P97911 Q543E5 Q62153 Q62154 RENI1_MOUSE Ren Ren-1 Ren1 uc007cqf.1 uc007cqf.2 uc007cqf.3 uc007cqf.4 Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Reaction=Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.; EC=3.4.23.15; Evidence=; Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Interacts with ATP6AP2. Secreted Membrane Note=Associated to membranes via binding to ATP6AP2. Kidney. Renal renin is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. In inbred mouse strains, there are at least two alleles which can occur at the Ren1 locus: Ren-1D and Ren-1C. The sequence shown is that of Ren-1C. Present as a single-copy gene in strains such as BALB/c and C57BL/6 while some strains such as Swiss and Akr contain two copies. Belongs to the peptidase A1 family. kidney development mesonephros development angiotensin maturation regulation of blood volume by renin-angiotensin renin-angiotensin regulation of aldosterone production endopeptidase activity aspartic-type endopeptidase activity receptor binding insulin-like growth factor receptor binding extracellular region extracellular space cytoplasm proteolysis regulation of blood pressure peptidase activity male gonad development hormone-mediated signaling pathway response to organic substance membrane hydrolase activity response to lipopolysaccharide cellular response to drug response to immobilization stress response to drug drinking behavior regulation of MAPK cascade apical part of cell cell maturation beta-amyloid metabolic process response to cAMP response to cGMP uc007cqf.1 uc007cqf.2 uc007cqf.3 uc007cqf.4 
ENSMUST00000094557.7 Golt1a ENSMUST00000094557.7 golgi transport 1A (from RefSeq NM_026680.4) ENSMUST00000094557.1 ENSMUST00000094557.2 ENSMUST00000094557.3 ENSMUST00000094557.4 ENSMUST00000094557.5 ENSMUST00000094557.6 GOT1A_MOUSE Golt1a NM_026680 Q9DCQ3 uc007cqa.1 uc007cqa.2 uc007cqa.3 May be involved in fusion of ER-derived transport vesicles with the Golgi complex. Golgi apparatus membrane ; Multi- pass membrane protein Belongs to the GOT1 family. Golgi cis cisterna Golgi membrane nuclear envelope endoplasmic reticulum Golgi apparatus trans-Golgi network protein transport membrane integral component of membrane vesicle-mediated transport uc007cqa.1 uc007cqa.2 uc007cqa.3 
ENSMUST00000094559.9 Arhgap24 ENSMUST00000094559.9 Rho GTPase activating protein 24, transcript variant 1 (from RefSeq NM_029270.2) Arhgap24 ENSMUST00000094559.1 ENSMUST00000094559.2 ENSMUST00000094559.3 ENSMUST00000094559.4 ENSMUST00000094559.5 ENSMUST00000094559.6 ENSMUST00000094559.7 ENSMUST00000094559.8 G3X9N1 G3X9N1_MOUSE NM_029270 uc008yiw.1 uc008yiw.2 uc008yiw.3 GTPase activator activity signal transduction positive regulation of GTPase activity uc008yiw.1 uc008yiw.2 uc008yiw.3 
ENSMUST00000094578.11 Sec31a ENSMUST00000094578.11 SEC31 homolog A, COPII coat complex component, transcript variant 2 (from RefSeq NM_026969.2) ENSMUST00000094578.1 ENSMUST00000094578.10 ENSMUST00000094578.2 ENSMUST00000094578.3 ENSMUST00000094578.4 ENSMUST00000094578.5 ENSMUST00000094578.6 ENSMUST00000094578.7 ENSMUST00000094578.8 ENSMUST00000094578.9 NM_026969 Q3UPL0 Q3UYH3 Q6IQZ3 Q7TQJ7 Q811J4 SC31A_MOUSE Sec31l1 uc008yhk.1 uc008yhk.2 uc008yhk.3 Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (By similarity). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with PDCD6; interaction takes place in response to cytosolic calcium increase and leads to bridge together the BCR(KLHL12) complex and SEC31A, leading to monoubiquitination. Interacts with KLHL12 (By similarity). Cytoplasm Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Endoplasmic reticulum membrane ; Peripheral membrane protein Note=Associates with membranes in a GTP-dependent manner (By similarity). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:25201882). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UPL0-1; Sequence=Displayed; Name=2; IsoId=Q3UPL0-2; Sequence=VSP_026753; Name=3; IsoId=Q3UPL0-3; Sequence=VSP_026752; The ALG-2-binding site motif-2 (ABS-2) contains a PXPGF sequence that binds hydrophobic pocket 3 of PDCD6. Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats. Belongs to the WD repeat SEC31 family. Golgi membrane structural molecule activity cytoplasm endosome endoplasmic reticulum endoplasmic reticulum membrane cytosol intracellular protein transport ER to Golgi vesicle-mediated transport endoplasmic reticulum organization ER to Golgi transport vesicle membrane protein transport membrane vesicle-mediated transport vesicle coat COPII vesicle coat ER to Golgi transport vesicle cytoplasmic vesicle intracellular membrane-bounded organelle calcium-dependent protein binding perinuclear region of cytoplasm response to calcium ion endoplasmic reticulum exit site cargo loading into COPII-coated vesicle COPII-coated vesicle budding uc008yhk.1 uc008yhk.2 uc008yhk.3 
ENSMUST00000094583.2 Ffar3 ENSMUST00000094583.2 free fatty acid receptor 3 (from RefSeq NM_001033316.2) ENSMUST00000094583.1 FFAR3_MOUSE Gm478 Gpr41 NM_001033316 Q3UFD7 uc009ggp.1 uc009ggp.2 G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin- sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate (PubMed:21518883, PubMed:22673524). Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion (PubMed:23401498). May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota (PubMed:18931303). May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine (PubMed:14722361, PubMed:20399779). Finally, may also play a role in glucose homeostasis (PubMed:22190648, PubMed:24748202). Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells (PubMed:23665276). Exhibits an SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016). Cell membrane; Multi-pass membrane protein. Expressed in white adipose tissue and skeletal muscle (at protein level). Abundantly expressed in sympathetic ganglia such as the superior cervical ganglion. Also expressed by intestinal endocrine cells. Expressed in sympathetic ganglia and trunks at 13.5 dpc, 15.5 dpc and P1. Up-regulated during myocyte and adipocyte differentiation (at protein level). Knockout mice display a retarded growth of sympathetic innervation and the superior cervical ganglion is significantly smaller. A heart rate decrease is also observed together with altered secretion of cardiac noradrenaline that might be due to reduced sympathetic nerve activity. Contrary to wild-type mice, oxygen consumption is not modified by feeding or starvation (PubMed:21518883). They also display impaired SCFA-triggered glucagon-like peptide 1/GLP-1 secretion and impaired glucose tolerance (PubMed:22190648). Finally, knockout mice display altered protective intestinal inflammatory and immune responses. Otherwise, they display normal growth and no major morphological abnormalities. Body weight, heart weight to body weight ratio, and metabolic parameters are comparable. However, there might be a gender bias, the effect on energy expenditure and body fat content being male specific (PubMed:23110765). Belongs to the G-protein coupled receptor 1 family. immune system process mucosal immune response positive regulation of cytokine production involved in immune response positive regulation of acute inflammatory response to non-antigenic stimulus regulation of heart rate by chemical signal G-protein coupled receptor activity plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway lipid binding regulation of norepinephrine secretion membrane integral component of membrane positive regulation of chemokine production glucose homeostasis positive regulation of action potential negative regulation of blood pressure regulation of insulin receptor signaling pathway regulation of hormone biosynthetic process cellular response to fatty acid regulation of peptide hormone secretion uc009ggp.1 uc009ggp.2 
ENSMUST00000094587.4 Pramel37 ENSMUST00000094587.4 PRAME like 37 (from RefSeq NM_198667.2) BC061212 ENSMUST00000094587.1 ENSMUST00000094587.2 ENSMUST00000094587.3 Gm7978 NM_198667 Pramel37 Pramel50 Q6P8K3 Q6P8K3_MOUSE uc008yeh.1 uc008yeh.2 uc008yeh.3 uc008yeh.4 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008yeh.1 uc008yeh.2 uc008yeh.3 uc008yeh.4 
ENSMUST00000094593.7 Pramel48 ENSMUST00000094593.7 PRAME like 48, transcript variant 1 (from RefSeq NM_177187.4) D5Ertd577e ENSMUST00000094593.1 ENSMUST00000094593.2 ENSMUST00000094593.3 ENSMUST00000094593.4 ENSMUST00000094593.5 ENSMUST00000094593.6 NM_177187 Pramel48 Q499F0 Q499F0_MOUSE uc008yev.1 uc008yev.2 uc008yev.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008yev.1 uc008yev.2 uc008yev.3 
ENSMUST00000094604.9 Galk2 ENSMUST00000094604.9 galactokinase 2, transcript variant 1 (from RefSeq NM_001291002.1) ENSMUST00000094604.1 ENSMUST00000094604.2 ENSMUST00000094604.3 ENSMUST00000094604.4 ENSMUST00000094604.5 ENSMUST00000094604.6 ENSMUST00000094604.7 ENSMUST00000094604.8 GALK2_MOUSE NM_001291002 Q68FH4 uc008mdg.1 uc008mdg.2 uc008mdg.3 uc008mdg.4 Acts on GalNAc (By similarity). Also acts as a galactokinase when galactose is present at high concentrations (By similarity). Reaction=ATP + N-acetyl-alpha-D-galactosamine = ADP + H(+) + N-acetyl- alpha-D-galactosamine 1-phosphate; Xref=Rhea:RHEA:12617, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:40356, ChEBI:CHEBI:61970, ChEBI:CHEBI:456216; EC=2.7.1.157; Monomer. Belongs to the GHMP kinase family. GalK subfamily. nucleotide binding galactokinase activity ATP binding galactose binding cytoplasm cytosol galactose metabolic process kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor galactose catabolic process via UDP-galactose N-acetylgalactosamine kinase activity carbohydrate phosphorylation uc008mdg.1 uc008mdg.2 uc008mdg.3 uc008mdg.4 
ENSMUST00000094615.8 Albfm1 ENSMUST00000094615.8 albumin superfamily member 1 (from RefSeq NM_001252661.1) 5830473C10Rik Albfm1 ENSMUST00000094615.1 ENSMUST00000094615.2 ENSMUST00000094615.3 ENSMUST00000094615.4 ENSMUST00000094615.5 ENSMUST00000094615.6 ENSMUST00000094615.7 F8VQ07 F8VQ07_MOUSE NM_001252661 uc029vji.1 uc029vji.2 uc029vji.3 Secreted fatty acid binding extracellular space cytoplasm zinc ion binding uc029vji.1 uc029vji.2 uc029vji.3 
ENSMUST00000094626.5 Cdh19 ENSMUST00000094626.5 cadherin 19, type 2, transcript variant 2 (from RefSeq NM_001356415.1) Cdh19 E9Q3A7 E9Q3A7_MOUSE ENSMUST00000094626.1 ENSMUST00000094626.2 ENSMUST00000094626.3 ENSMUST00000094626.4 NM_001356415 uc007chx.1 uc007chx.2 uc007chx.3 Cadherins are calcium-dependent cell adhesion proteins. Cell membrane ingle-pass type I membrane protein Membrane ; Single-pass type I membrane protein cell morphogenesis calcium ion binding plasma membrane cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cytoskeletal protein binding cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex adherens junction organization protein homodimerization activity cell-cell adhesion mediated by cadherin cadherin binding cell-cell adhesion uc007chx.1 uc007chx.2 uc007chx.3 
ENSMUST00000094632.6 Sars2 ENSMUST00000094632.6 seryl-aminoacyl-tRNA synthetase 2 (from RefSeq NM_023637.3) ENSMUST00000094632.1 ENSMUST00000094632.2 ENSMUST00000094632.3 ENSMUST00000094632.4 ENSMUST00000094632.5 NM_023637 Q68FL2 Q9CWP1 Q9JJL8 SYSM_MOUSE Sarsm uc009fzq.1 uc009fzq.2 uc009fzq.3 uc009fzq.4 uc009fzq.5 Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). Reaction=ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L- seryl-tRNA(Ser); Xref=Rhea:RHEA:12292, Rhea:RHEA-COMP:9669, Rhea:RHEA-COMP:9703, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:33384, ChEBI:CHEBI:78442, ChEBI:CHEBI:78533, ChEBI:CHEBI:456215; EC=6.1.1.11; Evidence=; Reaction=ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L- seryl-tRNA(Sec); Xref=Rhea:RHEA:42580, Rhea:RHEA-COMP:9742, Rhea:RHEA-COMP:10128, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:33384, ChEBI:CHEBI:78442, ChEBI:CHEBI:78533, ChEBI:CHEBI:456215; EC=6.1.1.11; Evidence=; Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. Homodimer. The tRNA molecule probably binds across the dimer. Mitochondrion matrix Ubiquitous. Consists of two distinct domains, a catalytic core and a N- terminal extension that is involved in tRNA binding. Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. nucleotide binding aminoacyl-tRNA ligase activity serine-tRNA ligase activity ATP binding mitochondrion mitochondrial matrix translation tRNA aminoacylation for protein translation seryl-tRNA aminoacylation ligase activity selenocysteinyl-tRNA(Sec) biosynthetic process uc009fzq.1 uc009fzq.2 uc009fzq.3 uc009fzq.4 uc009fzq.5 
ENSMUST00000094639.10 Map1a ENSMUST00000094639.10 microtubule-associated protein 1 A, transcript variant 1 (from RefSeq NM_032393.2) A2ARP8 A2ARP8_MOUSE ENSMUST00000094639.1 ENSMUST00000094639.2 ENSMUST00000094639.3 ENSMUST00000094639.4 ENSMUST00000094639.5 ENSMUST00000094639.6 ENSMUST00000094639.7 ENSMUST00000094639.8 ENSMUST00000094639.9 Map1a Mtap1a NM_032393 uc008lyi.1 uc008lyi.2 uc008lyi.3 uc008lyi.4 microtubule cytoskeleton organization microtubule microtubule binding uc008lyi.1 uc008lyi.2 uc008lyi.3 uc008lyi.4 
ENSMUST00000094641.9 Csn1s1 ENSMUST00000094641.9 casein alpha s1, transcript variant 1 (from RefSeq NM_007784.3) CASA1_MOUSE Csn1 Csna ENSMUST00000094641.1 ENSMUST00000094641.2 ENSMUST00000094641.3 ENSMUST00000094641.4 ENSMUST00000094641.5 ENSMUST00000094641.6 ENSMUST00000094641.7 ENSMUST00000094641.8 NM_007784 P19228 uc029vix.1 uc029vix.2 uc029vix.3 uc029vix.4 uc029vix.5 Important role in the capacity of milk to transport calcium phosphate. Secreted. Mammary gland specific. Secreted in milk. Belongs to the alpha-casein family. extracellular region extracellular space response to estradiol response to progesterone response to dehydroepiandrosterone response to 11-deoxycorticosterone uc029vix.1 uc029vix.2 uc029vix.3 uc029vix.4 uc029vix.5 
ENSMUST00000094644.11 Plekhg2 ENSMUST00000094644.11 pleckstrin homology domain containing, family G (with RhoGef domain) member 2, transcript variant 1 (from RefSeq NM_138752.3) E9QKB6 E9QKB6_MOUSE ENSMUST00000094644.1 ENSMUST00000094644.10 ENSMUST00000094644.2 ENSMUST00000094644.3 ENSMUST00000094644.4 ENSMUST00000094644.5 ENSMUST00000094644.6 ENSMUST00000094644.7 ENSMUST00000094644.8 ENSMUST00000094644.9 NM_138752 PLEKHG2 Plekhg2 uc009fyp.1 uc009fyp.2 uc009fyp.3 Rho guanyl-nucleotide exchange factor activity regulation of actin filament polymerization regulation of Rho protein signal transduction uc009fyp.1 uc009fyp.2 uc009fyp.3 
ENSMUST00000094649.11 Ugt2b36 ENSMUST00000094649.11 UDP glucuronosyltransferase 2 family, polypeptide B36 (from RefSeq NM_001029867.1) ENSMUST00000094649.1 ENSMUST00000094649.10 ENSMUST00000094649.2 ENSMUST00000094649.3 ENSMUST00000094649.4 ENSMUST00000094649.5 ENSMUST00000094649.6 ENSMUST00000094649.7 ENSMUST00000094649.8 ENSMUST00000094649.9 NM_001029867 Q3UEP4 Q3UEP4_MOUSE Ugt2b36 uc008xye.1 uc008xye.2 Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; Membrane ; Single- pass membrane protein Belongs to the UDP-glycosyltransferase family. UDP-glycosyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups intracellular membrane-bounded organelle uc008xye.1 uc008xye.2 
ENSMUST00000094651.4 Eid2b ENSMUST00000094651.4 EP300 interacting inhibitor of differentiation 2B (from RefSeq NM_001177427.2) E9Q2Y0 E9Q2Y0_MOUSE ENSMUST00000094651.1 ENSMUST00000094651.2 ENSMUST00000094651.3 Eid2b NM_001177427 uc012fgp.1 uc012fgp.2 uc012fgp.3 Nucleus nucleus identical protein binding negative regulation of myoblast differentiation negative regulation of transcription, DNA-templated uc012fgp.1 uc012fgp.2 uc012fgp.3 
ENSMUST00000094653.6 Gtsf1l ENSMUST00000094653.6 gametocyte specific factor 1-like (from RefSeq NM_026630.3) ENSMUST00000094653.1 ENSMUST00000094653.2 ENSMUST00000094653.3 ENSMUST00000094653.4 ENSMUST00000094653.5 Fam112a GTSFL_MOUSE NM_026630 Q3TVG1 Q9CWD0 Q9D2S8 uc033hre.1 uc033hre.2 uc033hre.3 Belongs to the UPF0224 (FAM112) family. molecular_function cellular_component biological_process metal ion binding uc033hre.1 uc033hre.2 uc033hre.3 
ENSMUST00000094657.10 Dnajc8 ENSMUST00000094657.10 DnaJ heat shock protein family (Hsp40) member C8 (from RefSeq NM_172400.3) DNJC8_MOUSE ENSMUST00000094657.1 ENSMUST00000094657.2 ENSMUST00000094657.3 ENSMUST00000094657.4 ENSMUST00000094657.5 ENSMUST00000094657.6 ENSMUST00000094657.7 ENSMUST00000094657.8 ENSMUST00000094657.9 NM_172400 Q6NZB0 Q6PG72 Q8C2M6 uc012dmi.1 uc012dmi.2 uc012dmi.3 Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells. Interacts with SRPK1. Interacts with HSP70 (HSPA1A or HSPA1B). Nucleus Sequence=BAC40283.1; Type=Frameshift; Evidence=; nucleus nucleoplasm cytosol Hsp70 protein binding intercellular bridge uc012dmi.1 uc012dmi.2 uc012dmi.3 
ENSMUST00000094662.2 Gm10300 ENSMUST00000094662.2 Gm10300 (from geneSymbol) AK044726 ENSMUST00000094662.1 uc290qjp.1 uc290qjp.2 uc290qjp.1 uc290qjp.2 
ENSMUST00000094663.4 Gal3st2 ENSMUST00000094663.4 galactose-3-O-sulfotransferase 2 (from RefSeq NM_199366.5) A2RTS9 A2RTS9_MOUSE ENSMUST00000094663.1 ENSMUST00000094663.2 ENSMUST00000094663.3 Gal3st2 NM_199366 uc007ces.1 uc007ces.2 uc007ces.3 Belongs to the galactose-3-O-sulfotransferase family. galactosylceramide sulfotransferase activity Golgi apparatus glycolipid biosynthetic process membrane integral component of membrane transferase activity uc007ces.1 uc007ces.2 uc007ces.3 
ENSMUST00000094665.5 Pla2g4d ENSMUST00000094665.5 phospholipase A2, group IVD (from RefSeq NM_001024137.1) A2AQJ1 ENSMUST00000094665.1 ENSMUST00000094665.2 ENSMUST00000094665.3 ENSMUST00000094665.4 NM_001024137 PA24D_MOUSE Pla2g4d Q3TJC5 Q50L43 uc008lvh.1 uc008lvh.2 uc008lvh.3 Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:15866882). Compared to its human ortholog, may have no preference for the fatty acid found at the sn-2 position (PubMed:15866882). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn- glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40812; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40432; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Stimulated by cytosolic Ca(2+). Kinetic parameters: Vmax=13.4 pmol/min/mg enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphocholine as substrate (at 37 degrees Celsius) ; Vmax=8.1 pmol/min/mg enzyme with 1-hexadecanoyl-2-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phosphocholine as substrate (at 37 degrees Celsius) ; Vmax=14.5 pmol/min/mg enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine as substrate (at 37 degrees Celsius) ; Vmax=19.9 pmol/min/mg enzyme with 1-hexadecanoyl-2-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phosphoethanolamine as substrate (at 37 degrees Celsius) ; Vmax=16.4 pmol/min/mg enzyme with 1-hexadecanoyl-sn-glycero-3- phosphocholine as substrate (at 37 degrees Celsius) ; Lipid metabolism; fatty acid metabolism. Cytoplasm, cytosol Membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Translocates to perinuclear membranes that may correspond to endoplasmic reticulum or Golgi in a calcium-dependent fashion. Weakly or not expressed in most tissues. Detected in placenta of 17.5 dpc embryos. The N-terminal C2 domain mediates the association with lipid membranes upon calcium binding. An additional second C2 domain may stand in between the C2 domain and the PLA2c domain. phospholipase activity phospholipase A2 activity calcium ion binding calcium-dependent phospholipid binding cytoplasm cytosol lipid metabolic process fatty acid metabolic process phospholipid catabolic process membrane lipid catabolic process hydrolase activity glycerophospholipid catabolic process metal ion binding calcium-dependent phospholipase A2 activity uc008lvh.1 uc008lvh.2 uc008lvh.3 
ENSMUST00000094681.11 Wipf1 ENSMUST00000094681.11 WAS/WASL interacting protein family, member 1, transcript variant 2 (from RefSeq NM_153138.4) ENSMUST00000094681.1 ENSMUST00000094681.10 ENSMUST00000094681.2 ENSMUST00000094681.3 ENSMUST00000094681.4 ENSMUST00000094681.5 ENSMUST00000094681.6 ENSMUST00000094681.7 ENSMUST00000094681.8 ENSMUST00000094681.9 NM_153138 Q3U0U8 Q8K1I7 WIPF1_MOUSE Waspip Wip uc008kcw.1 uc008kcw.2 uc008kcw.3 uc008kcw.4 Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation (By similarity). Plays a role in the formation of cell ruffles. Binds to WAS within the N-terminal region, at a site distinct from the CDC42-binding site. Binds profilin and actin (By similarity). Binds to WASL. Interacts with DBNL. Interacts with DBNL. Interacts with FNBP1L (via the SH3 domain) (By similarity). Q8K1I7; P70315: Was; NbExp=3; IntAct=EBI-644216, EBI-644195; Cytoplasmic vesicle Cytoplasm, cytoskeleton Cell projection, ruffle Note=Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity). Recruited to PIP5K-induced vesicle surfaces in the absence of functional WASL. Belongs to the verprolin family. actin cortical patch assembly ruffle actin binding protein binding cytoplasm cytoskeleton actin filament endocytosis actin cytoskeleton SH3 domain binding actin cytoskeleton organization actin filament-based movement actin cortical patch cytoplasmic vesicle cell projection positive regulation of protein export from nucleus actin filament binding actin cortical patch localization response to other organism uc008kcw.1 uc008kcw.2 uc008kcw.3 uc008kcw.4 
ENSMUST00000094693.11 Srsf5 ENSMUST00000094693.11 May be required for progression through G1 and entry into S phase of cell growth. May play a regulatory role in pre-mRNA splicing. Autoregulates its own expression. Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (By similarity). (from UniProt O35326) AK142009 ENSMUST00000094693.1 ENSMUST00000094693.10 ENSMUST00000094693.2 ENSMUST00000094693.3 ENSMUST00000094693.4 ENSMUST00000094693.5 ENSMUST00000094693.6 ENSMUST00000094693.7 ENSMUST00000094693.8 ENSMUST00000094693.9 Hrs O35326 Q640L9 SRSF5_MOUSE Sfrs5 uc007obo.1 uc007obo.2 May be required for progression through G1 and entry into S phase of cell growth. May play a regulatory role in pre-mRNA splicing. Autoregulates its own expression. Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (By similarity). Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2 (By similarity). Interacts (via RS domain) with PHF5A (via N-terminus). Nucleus Extensively phosphorylated on serine residues in the RS domain. Belongs to the splicing factor SR family. regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding protein binding nucleus mRNA processing RNA splicing response to wounding nuclear speck response to insulin positive regulation of RNA splicing protein kinase B binding mRNA cis splicing, via spliceosome RS domain binding uc007obo.1 uc007obo.2 
ENSMUST00000094695.12 Rmdn3 ENSMUST00000094695.12 regulator of microtubule dynamics 3 (from RefSeq NM_001033136.3) A9UN03 ENSMUST00000094695.1 ENSMUST00000094695.10 ENSMUST00000094695.11 ENSMUST00000094695.2 ENSMUST00000094695.3 ENSMUST00000094695.4 ENSMUST00000094695.5 ENSMUST00000094695.6 ENSMUST00000094695.7 ENSMUST00000094695.8 ENSMUST00000094695.9 Fam82a2 Fam82c NM_001033136 Q3U5Y8 Q3UB61 Q3UJU9 Q6P8M2 Q7TNF2 RMD3_MOUSE Rmdn3 uc008lte.1 uc008lte.2 uc008lte.3 uc008lte.4 Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity). Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB. Interacts (via FFAT motif) with MOSPD2 (via MSP domain). Interacts (via phosphorylated FFAT motif) with MOSPD2, VAPA and VAPB. Mitochondrion outer membrane ; Single-pass membrane protein Cytoplasm Nucleus Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. The transmembrane region is required for mitochondrial localization. The FFAT motif is required for interaction with MOSPD2. The FFAT motif is involved in the interaction with VAPA and VAPB and its phosphorylation regulates these interactions. Phosphorylation at Thr-160 of the FFAT motif activates interaction with MOSPD2, VAPA and VAPB. Belongs to the RMDN family. Sequence=AAH55754.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH61186.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=FAA00420.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; spindle pole molecular_function nucleus cytoplasm mitochondrion mitochondrial outer membrane spindle cytoskeleton microtubule cellular calcium ion homeostasis apoptotic process membrane integral component of membrane cell differentiation mitochondrial membrane uc008lte.1 uc008lte.2 uc008lte.3 uc008lte.4 
ENSMUST00000094698.2 Rbm44 ENSMUST00000094698.2 RNA binding motif protein 44 (from RefSeq NM_001033408.5) ENSMUST00000094698.1 Gm817 NM_001033408 Q3V089 RBM44_MOUSE uc007bzv.1 uc007bzv.2 Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility. Homodimer. Interacts with TEX14. Cytoplasm Note=Detected in the intercellular bridges. Localization to intercellular bridges is identified in all stages of tubules but dynamically increases from stage I pachytene spermatocytes to stage XII secondary spermatocytes and disappears after the formation of step 1 round spermatids (stage I). In addition, it is localized in the cytoplasm in pachytene spermatocytes to secondary spermatocytes. The cytoplasmic signals also increases dramatically in stages X-XII, decreases from step 1 to step 3 spermatids, and disappears in step 4 spermatids. Highly expressed in testis. Also expressed in other tissues at lower level. Present in testes beginning at postnatal day 5 (at protein level). No visible phenotype. Null male mice produce an increased number of sperm and show enhanced fertility. nucleic acid binding RNA binding mRNA binding protein binding nucleus cytoplasm biological_process protein homodimerization activity intercellular bridge ribonucleoprotein complex uc007bzv.1 uc007bzv.2 
ENSMUST00000094705.3 Zfp575 ENSMUST00000094705.3 zinc finger protein 575, transcript variant 2 (from RefSeq NM_001419146.1) ENSMUST00000094705.1 ENSMUST00000094705.2 NM_001419146 Q3TXZ1 ZN575_MOUSE Znf575 uc009fqa.1 uc009fqa.2 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus biological_process metal ion binding uc009fqa.1 uc009fqa.2 
ENSMUST00000094712.5 Tmem35b ENSMUST00000094712.5 transmembrane protein 35B (from RefSeq NM_001099319.2) A2A7U4 ENSMUST00000094712.1 ENSMUST00000094712.2 ENSMUST00000094712.3 ENSMUST00000094712.4 Gm12942 NM_001099319 Q3U0Y2 TM35B_MOUSE Tmem35b Zmym6nb uc008uun.1 uc008uun.2 uc008uun.3 uc008uun.4 Membrane ; Multi-pass membrane protein Belongs to the DoxX family. molecular_function cellular_component biological_process membrane integral component of membrane uc008uun.1 uc008uun.2 uc008uun.3 uc008uun.4 
ENSMUST00000094715.9 Grxcr1 ENSMUST00000094715.9 glutaredoxin, cysteine rich 1 (from RefSeq NM_001018019.3) ENSMUST00000094715.1 ENSMUST00000094715.2 ENSMUST00000094715.3 ENSMUST00000094715.4 ENSMUST00000094715.5 ENSMUST00000094715.6 ENSMUST00000094715.7 ENSMUST00000094715.8 GRCR1_MOUSE NM_001018019 Q50H32 pi uc008xqi.1 uc008xqi.2 uc008xqi.3 May play a role in actin filament architecture in developing stereocilia of sensory cells. Cell projection, stereocilium Cell projection, microvillus Cell projection, kinocilium Note=In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia. In the inner ear, expressed predominantly in sensory hair cells and their stereocilia bundles with higher levels in outer hair cells (OHC) at P1 and in inner hair cells (IHC) at P5. At P1, expression is prominent in each row of stereocilia within bundles including immature shorter stereocilia. Expression is also observed in apical microvilli of sensory cells at P1 and in kinocilia at P1 and P5. In the adult, expression is localized throughout the length of the stereocilia of both OHC and IHC (at protein level). Note=Defects in Grxcr1 are the cause of the pirouette (pi) phenotype which is characterized by vestibular defects and profound deafness with affected mice displaying abnormally thin and slightly shortened sterocilia. Belongs to the GRXCR1 family. molecular_function microvillus cilium sensory perception of sound electron carrier activity negative regulation of phosphatase activity protein disulfide oxidoreductase activity electron transport chain stereocilium auditory receptor cell differentiation cell projection cell redox homeostasis post-embryonic animal organ morphogenesis inner ear development oxidation-reduction process kinocilium vestibular receptor cell development inner ear receptor cell development inner ear receptor stereocilium organization uc008xqi.1 uc008xqi.2 uc008xqi.3 
ENSMUST00000094753.6 Ceacam20 ENSMUST00000094753.6 CEA cell adhesion molecule 20 (from RefSeq NM_027839.2) CEA20_MOUSE Ceacam20 ENSMUST00000094753.1 ENSMUST00000094753.2 ENSMUST00000094753.3 ENSMUST00000094753.4 ENSMUST00000094753.5 NM_027839 Q80Y42 Q9D2Z1 uc012fbl.1 uc012fbl.2 uc012fbl.3 uc012fbl.4 Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response. Interacts (via extracellular domain) with PTPRH (via extracellular domain); the interaction dephosphorylates CEACAM20. Interacts (phosphorylated form) with SYK (via SH2 domains); the interaction further enhances CEACAM20 phosphorylation. Cell projection, microvillus membrane ; Single-pass type I membrane protein Apical cell membrane ; Single-pass type I membrane protein Note=Colocalizes with PTPRH and CEACAM1 at the apical brush border of intestinal cells. Strongly expressed in the small intestine and colon (at protein level) (PubMed:25908210, PubMed:26195794). Minimal expression in other tissues (at protein level) (PubMed:26195794). Highly expressed in cecum, colon, ileum, jejunum, and testis, and also detected at lower levels in salivary gland and thymus (PubMed:16139472). In intestinal epithelium, up-regulated in the presence of Gram-positive commensal gut bacteria. May also be up-regulated by interferon gamma (IFNG) and butyrate (a product of bacterial fermentation). Phosphorylated on tyrosine residues by SYK, SRC and FYN in vitro. Belongs to the immunoglobulin superfamily. CEA family. positive regulation of cytokine production immune system process protein binding plasma membrane response to bacterium membrane integral component of membrane apical plasma membrane microvillus membrane cell projection uc012fbl.1 uc012fbl.2 uc012fbl.3 uc012fbl.4 
ENSMUST00000094761.11 Stk40 ENSMUST00000094761.11 serine/threonine kinase 40, transcript variant 2 (from RefSeq NM_028800.3) B1AW01 ENSMUST00000094761.1 ENSMUST00000094761.10 ENSMUST00000094761.2 ENSMUST00000094761.3 ENSMUST00000094761.4 ENSMUST00000094761.5 ENSMUST00000094761.6 ENSMUST00000094761.7 ENSMUST00000094761.8 ENSMUST00000094761.9 Lyk4 NM_028800 Q3U3G3 Q7TNL3 Q811D6 Q8BKT1 Q9D7K3 STK40_MOUSE uc008usl.1 uc008usl.2 uc008usl.3 uc008usl.4 May be a negative regulator of NF-kappa-B and p53-mediated gene transcription. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Q7TNL3-1; Q8BP92: Rcn2; NbExp=3; IntAct=EBI-15828080, EBI-642694; Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TNL3-1; Sequence=Displayed; Name=2; IsoId=Q7TNL3-2; Sequence=VSP_020901; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Sequence=AAH46981.1; Type=Erroneous initiation; Evidence=; nucleotide binding respiratory system process protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol glycogen metabolic process protein phosphorylation regulation of gene expression kinase activity phosphorylation transferase activity lung development multicellular organism growth negative regulation of apoptotic process regulation of MAPK cascade lung alveolus development lung morphogenesis uc008usl.1 uc008usl.2 uc008usl.3 uc008usl.4 
ENSMUST00000094762.10 Relb ENSMUST00000094762.10 avian reticuloendotheliosis viral (v-rel) oncogene related B, transcript variant 1 (from RefSeq NM_009046.3) ENSMUST00000094762.1 ENSMUST00000094762.2 ENSMUST00000094762.3 ENSMUST00000094762.4 ENSMUST00000094762.5 ENSMUST00000094762.6 ENSMUST00000094762.7 ENSMUST00000094762.8 ENSMUST00000094762.9 NM_009046 Q04863 Q8VE46 RELB_MOUSE uc033ixd.1 uc033ixd.2 uc033ixd.3 NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post- translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I- kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (By similarity). Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex (By similarity). Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID. Interacts with BMAL1 and the interaction is enhanced in the presence of CLOCK. Q04863; PRO_0000030313 [P25799]: Nfkb1; NbExp=2; IntAct=EBI-1209145, EBI-1209141; Q04863; Q9WTK5: Nfkb2; NbExp=3; IntAct=EBI-1209145, EBI-1209166; Q04863; Q9Z1E3: Nfkbia; NbExp=4; IntAct=EBI-1209145, EBI-644427; Q04863; O54910: Nfkbie; NbExp=2; IntAct=EBI-1209145, EBI-6688774; Q04863; Q04863: Relb; NbExp=3; IntAct=EBI-1209145, EBI-1209145; Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with NEK6 in the centrosome. Expressed in intestine, thymus and spleen. Undetectable in liver, bome marrow, kidney and testis. Both N- and C-terminal domains are required for transcriptional activation. Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm centrosome microtubule organizing center cytosol cytoskeleton regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter inflammatory response I-kappaB kinase/NF-kappaB signaling positive regulation of gene expression transcriptional repressor complex antigen processing and presentation protein kinase binding lymphocyte differentiation negative regulation of interferon-beta production circadian regulation of gene expression macromolecular complex response to cytokine NIK/NF-kappaB signaling T-helper 1 type immune response identical protein binding myeloid dendritic cell differentiation T-helper 1 cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process cellular response to osmotic stress uc033ixd.1 uc033ixd.2 uc033ixd.3 
ENSMUST00000094769.13 Airim ENSMUST00000094769.13 AFG2 interacting ribosome maturation factor, transcript variant 1 (from RefSeq NM_177573.3) AIRIM_MOUSE ENSMUST00000094769.1 ENSMUST00000094769.10 ENSMUST00000094769.11 ENSMUST00000094769.12 ENSMUST00000094769.2 ENSMUST00000094769.3 ENSMUST00000094769.4 ENSMUST00000094769.5 ENSMUST00000094769.6 ENSMUST00000094769.7 ENSMUST00000094769.8 ENSMUST00000094769.9 NM_177573 Q148T1 Q3TU44 Q499E6 Q8BI05 uc008url.1 uc008url.2 uc008url.3 Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. Acts together with AFG2A, AFG2B and CINP. Interacts with AFG2A, AFG2B and CINP. Does not associate with pre-60S ribosomal particles. Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q499E6-1; Sequence=Displayed; Name=2; IsoId=Q499E6-2; Sequence=VSP_022736; Name=3; IsoId=Q499E6-3; Sequence=VSP_022735; Phosphorylated on serines by CK2 kinase. molecular_function nucleus cytoplasm biological_process uc008url.1 uc008url.2 uc008url.3 
ENSMUST00000094782.10 Inpp5b ENSMUST00000094782.10 inositol polyphosphate-5-phosphatase B, transcript variant 1 (from RefSeq NM_008385.4) ENSMUST00000094782.1 ENSMUST00000094782.2 ENSMUST00000094782.3 ENSMUST00000094782.4 ENSMUST00000094782.5 ENSMUST00000094782.6 ENSMUST00000094782.7 ENSMUST00000094782.8 ENSMUST00000094782.9 I5P2_MOUSE NM_008385 O54996 Q8CF65 Q8K337 Q91ZF8 uc008uqy.1 uc008uqy.2 uc008uqy.3 This gene encodes a member of the inositol polyphosphate-5-phosphatase (INPP5) family. This protein hydrolyzes the 5' phosphate from phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol-1,4,5-trisphosphate, which results in changes to multiple signaling pathways. This protein may be involved in protein trafficking and secretion. Homozygous knockout mice exhibit impaired spermatogenesis and male sterility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]. Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5- trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol 4-phosphate) + phosphate; Xref=Rhea:RHEA:22764, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456; EC=3.1.3.36; Evidence=; Interacts with APPL1, PHETA1 and PHETA2. Interacts with several Rab GTPases, at least RAB1A, RAB2A, RAB5A, RAB6A, RAB8A, RAB9A and RAB33B; these interactions may play a dual role in targeting INPP5B to the specific membranes and stimulating its phosphatase activity. Interacts preferentially with non-phosphorylated RAB8A; phosphorylation of RAB8A on 'Thr-72' disrupts this interaction (By similarity). Interacts with INPP5F (PubMed:25869668). Cytoplasm, cytosol Endoplasmic reticulum-Golgi intermediate compartment Early endosome membrane Membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, phagosome membrane Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K337-1; Sequence=Displayed; Name=2; IsoId=Q8K337-2; Sequence=VSP_042226, VSP_042227; Name=3; IsoId=Q8K337-3; Sequence=VSP_042224, VSP_042225; Detected in kidney, liver, brain, lung and testis (at protein level). Detected in kidney and liver, and at lower levels in brain, lung and testis. The ASH (ASPM-SPD2-Hydin) and RhoGAP (Rho GTPase activating) domains form a single folding module. The ASH domain has an immunoglobulin-like fold, the Rho-GAP domain lacks the catalytic arginine and is catalytically inactive. The ASH-RhoGAP module regulates the majority of the protein-protein interactions currently described. The ASH domain mediates association with membrane-targeting Rab GTPases. The Rho-GAP domain interacts with the endocytic adapter APPL1, which is then displaced by PHETA1 and PHETA2 as endosomes mature, all three interactions rely on F&H motifs, an approximately 12-13 amino- acid sequence centered around Phe and His residues essential for binding (By similarity). Isoprenylation at Cys-990 may be required for localization at the membrane. May be proteolytically cleaved after Lys-320 as inferred from N- terminal protein sequence of the 75 kda form. Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. Sequence=AAB95412.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; in utero embryonic development phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity cytoplasm endosome endoplasmic reticulum-Golgi intermediate compartment cytosol signal transduction spermatogenesis membrane integral component of membrane hydrolase activity flagellated sperm motility phagocytic vesicle membrane cytoplasmic vesicle early endosome membrane inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation metal ion binding inositol-1,4,5-trisphosphate 5-phosphatase activity inositol phosphate phosphatase activity regulation of protein processing uc008uqy.1 uc008uqy.2 uc008uqy.3 
ENSMUST00000094783.7 Pcdh7 ENSMUST00000094783.7 protocadherin 7, transcript variant 3 (from RefSeq NM_001310606.1) E9Q2S0 E9Q2S0_MOUSE ENSMUST00000094783.1 ENSMUST00000094783.2 ENSMUST00000094783.3 ENSMUST00000094783.4 ENSMUST00000094783.5 ENSMUST00000094783.6 NM_001310606 Pcdh7 uc008xlu.1 uc008xlu.2 uc008xlu.3 uc008xlu.4 uc008xlu.5 calcium ion binding protein binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008xlu.1 uc008xlu.2 uc008xlu.3 uc008xlu.4 uc008xlu.5 
ENSMUST00000094787.8 Slc34a2 ENSMUST00000094787.8 solute carrier family 34 (sodium phosphate), member 2 (from RefSeq NM_011402.3) ENSMUST00000094787.1 ENSMUST00000094787.2 ENSMUST00000094787.3 ENSMUST00000094787.4 ENSMUST00000094787.5 ENSMUST00000094787.6 ENSMUST00000094787.7 NM_011402 NPT2B_MOUSE Npt2b Q9DBP0 Q9Z290 uc008xlb.1 uc008xlb.2 uc008xlb.3 uc008xlb.4 uc008xlb.5 Involved in actively transporting phosphate into cells via Na(+) cotransport. Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in); Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71256; Evidence=; Kinetic parameters: KM=50 mM for phosphate ; KM=33 mM for sodium ; pH dependence: Optimum pH is 6.0. ; Apical cell membrane ulti-pass membrane protein Note=Localized at the brush border membranes of enterocytes. Highly abundant in the ileum of small intestine, whereas it is almost absent in the duodenum and in the jejunum. Up-regulated in the entire small intestine by low-phosphate diet. Up-regulated by metabolic acidosis. Belongs to the SLC34A transporter family. in utero embryonic development sodium:phosphate symporter activity plasma membrane brush border ion transport sodium ion transport phosphate ion transport symporter activity sodium-dependent phosphate transmembrane transporter activity membrane integral component of membrane apical plasma membrane protein domain specific binding cellular phosphate ion homeostasis sodium ion binding brush border membrane microvillus membrane vesicle sodium ion transmembrane transport phosphate ion binding response to estrogen sodium-dependent phosphate transport transmembrane transport uc008xlb.1 uc008xlb.2 uc008xlb.3 uc008xlb.4 uc008xlb.5 
ENSMUST00000094790.5 Gipr ENSMUST00000094790.5 gastric inhibitory polypeptide receptor (from RefSeq NM_001080815.1) ENSMUST00000094790.1 ENSMUST00000094790.2 ENSMUST00000094790.3 ENSMUST00000094790.4 GIPR_MOUSE NM_001080815 Q0P543 Q80UB4 uc009fkw.1 uc009fkw.2 uc009fkw.3 This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). May form homodimers and heterodimers with GLP1R. Cell membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0P543-1; Sequence=Displayed; Name=2; IsoId=Q0P543-2; Sequence=VSP_028433, VSP_028434; N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER. Belongs to the G-protein coupled receptor 2 family. desensitization of G-protein coupled receptor protein signaling pathway transmembrane signaling receptor activity G-protein coupled receptor activity plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway G-protein coupled peptide receptor activity response to glucose membrane integral component of membrane gastric inhibitory peptide receptor activity peptide hormone binding endocrine pancreas development positive regulation of insulin secretion signaling receptor activity gastric inhibitory peptide signaling pathway positive regulation of cAMP-mediated signaling response to axon injury response to calcium ion response to fatty acid uc009fkw.1 uc009fkw.2 uc009fkw.3 
ENSMUST00000094793.12 Psg21 ENSMUST00000094793.12 pregnancy-specific beta-1-glycoprotein 21 (from RefSeq NM_027403.4) ENSMUST00000094793.1 ENSMUST00000094793.10 ENSMUST00000094793.11 ENSMUST00000094793.2 ENSMUST00000094793.3 ENSMUST00000094793.4 ENSMUST00000094793.5 ENSMUST00000094793.6 ENSMUST00000094793.7 ENSMUST00000094793.8 ENSMUST00000094793.9 NM_027403 Psg21 Q9DAV5 Q9DAV5_MOUSE uc009fjp.1 uc009fjp.2 uc009fjp.3 molecular_function cellular_component female pregnancy biological_process uc009fjp.1 uc009fjp.2 uc009fjp.3 
ENSMUST00000094794.5 Psg27 ENSMUST00000094794.5 pregnancy-specific beta-1-glycoprotein 27 (from RefSeq NM_001037168.1) EG545925 ENSMUST00000094794.1 ENSMUST00000094794.2 ENSMUST00000094794.3 ENSMUST00000094794.4 NM_001037168 Psg27 Q497W2 Q497W2_MOUSE uc009fjn.1 uc009fjn.2 molecular_function cellular_component female pregnancy biological_process uc009fjn.1 uc009fjn.2 
ENSMUST00000094795.5 Psg25 ENSMUST00000094795.5 pregnancy-specific beta-1-glycoprotein 25 (from RefSeq NM_054060.1) ENSMUST00000094795.1 ENSMUST00000094795.2 ENSMUST00000094795.3 ENSMUST00000094795.4 NM_054060 Psg25 Q497W1 Q497W1_MOUSE uc009fjm.1 uc009fjm.2 uc009fjm.3 molecular_function cellular_component female pregnancy biological_process uc009fjm.1 uc009fjm.2 uc009fjm.3 
ENSMUST00000094798.5 Psg26 ENSMUST00000094798.5 pregnancy-specific beta-1-glycoprotein 26 (from RefSeq NM_001029893.1) EG574429 ENSMUST00000094798.1 ENSMUST00000094798.2 ENSMUST00000094798.3 ENSMUST00000094798.4 NM_001029893 Psg26 Q4KL65 Q4KL65_MOUSE uc009fjl.1 uc009fjl.2 uc009fjl.3 molecular_function cellular_component female pregnancy biological_process uc009fjl.1 uc009fjl.2 uc009fjl.3 
ENSMUST00000094799.3 Ceacam11 ENSMUST00000094799.3 CEA cell adhesion molecule 11 (from RefSeq NM_023289.2) Ceacam11 ENSMUST00000094799.1 ENSMUST00000094799.2 NM_023289 Q9D0Z8 Q9D0Z8_MOUSE uc009fjc.1 uc009fjc.2 uc009fjc.3 molecular_function cellular_component biological_process uc009fjc.1 uc009fjc.2 uc009fjc.3 
ENSMUST00000094807.6 Pnma8b ENSMUST00000094807.6 PNMA family member 8B (from RefSeq NM_001099636.2) ENSMUST00000094807.1 ENSMUST00000094807.2 ENSMUST00000094807.3 ENSMUST00000094807.4 ENSMUST00000094807.5 G3X9N3 G3X9N3_MOUSE NM_001099636 Pnma8b Pnmal2 uc009fio.1 uc009fio.2 uc009fio.3 Belongs to the PNMA family. molecular_function cellular_component biological_process uc009fio.1 uc009fio.2 uc009fio.3 
ENSMUST00000094814.6 Cited4 ENSMUST00000094814.6 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 (from RefSeq NM_019563.2) CITE4_MOUSE Cited4 ENSMUST00000094814.1 ENSMUST00000094814.2 ENSMUST00000094814.3 ENSMUST00000094814.4 ENSMUST00000094814.5 Mrg2 NM_019563 Q66JX0 Q8R176 Q9CZV4 Q9WUL8 uc008unl.1 uc008unl.2 uc008unl.3 Acts as a transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. Interacts via its C-terminal region with the CH1 domain of CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms. Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q9WUL8-1; Sequence=Displayed; Name=2 ; IsoId=Q9WUL8-2; Sequence=VSP_052035; Name=3 ; IsoId=Q9WUL8-3; Sequence=VSP_052036; Strongly expressed in heart, spleen and testis, and weakly in liver and kidney. Undetectable in nulliparous mammary glands but strongly expressed in 11.5 dpc pregnant mammary glands. Strong expression continued until the end of the lactacting stage and then rapidly diminished during the weaning stage. Belongs to the CITED family. transcription coactivator activity nucleus cytoplasm regulation of transcription, DNA-templated response to estrogen positive regulation of transcription, DNA-templated uc008unl.1 uc008unl.2 uc008unl.3 
ENSMUST00000094819.5 Zmynd12 ENSMUST00000094819.5 zinc finger, MYND domain containing 12 (from RefSeq NM_001014900.2) A2BGJ5 A2BGJ5_MOUSE ENSMUST00000094819.1 ENSMUST00000094819.2 ENSMUST00000094819.3 ENSMUST00000094819.4 NM_001014900 Zmynd12 uc008umn.1 uc008umn.2 uc008umn.3 uc008umn.4 molecular_function biological_process uc008umn.1 uc008umn.2 uc008umn.3 uc008umn.4 
ENSMUST00000094823.4 Cldn19 ENSMUST00000094823.4 claudin 19, transcript variant 2 (from RefSeq NM_153105.7) CLD19_MOUSE ENSMUST00000094823.1 ENSMUST00000094823.2 ENSMUST00000094823.3 NM_153105 Q8R4B7 Q9ET38 uc008ult.1 uc008ult.2 uc008ult.3 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. siRNA knockdown of this gene in mice develops the FHHNC (familial hypomagnesemia with hypercalciuria and nephrocalcinosis) symptoms of chronic renal wasting of magnesium and calcium together with defective renal salt handling. The protein encoded by this gene interacts with another family member, Claudin 16, and their interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. This protein is a constituent of tight junctions in the Schwann cells of peripheral myelinated nerves and the gene deficiency affects the nerve conduction of peripheral myelinated fibers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. (Microbial infection) Interacts (via both extracellular domains) with Clostridium perfringens enterotoxin CPE; the interaction disrupts claudin assembly in tight junctions. Q9ET38; P01558: cpe; Xeno; NbExp=2; IntAct=EBI-8036280, EBI-16142958; Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ET38-1; Sequence=Displayed; Name=2; IsoId=Q9ET38-2; Sequence=VSP_010343; Belongs to the claudin family. structural molecule activity protein binding nucleus cytoplasm plasma membrane bicellular tight junction membrane integral component of membrane basolateral plasma membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules neuronal action potential propagation cell junction identical protein binding apical junction complex apical junction assembly uc008ult.1 uc008ult.2 uc008ult.3 
ENSMUST00000094833.10 Zbtb49 ENSMUST00000094833.10 zinc finger and BTB domain containing 49, transcript variant 6 (from RefSeq NR_174700.1) ENSMUST00000094833.1 ENSMUST00000094833.2 ENSMUST00000094833.3 ENSMUST00000094833.4 ENSMUST00000094833.5 ENSMUST00000094833.6 ENSMUST00000094833.7 ENSMUST00000094833.8 ENSMUST00000094833.9 NR_174700 Q8BXX2 Q8CID4 Q8K2Z6 ZBT49_MOUSE Zfp509 Znf509 uc008xgc.1 uc008xgc.2 uc008xgc.3 Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. Interacts with EP300, KAT5/Tip60 and ZBTB17. The interaction with EP300 is direct and leads to synergistic induction of CDKN1A. On the CDKN1A promoter, forms a complex with ZBTB17; this interaction leads to additive CDKN1A transactivation. The interaction with ZBTB17 may block ZBTB17 repressor activity. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BXX2-1; Sequence=Displayed; Name=2; IsoId=Q8BXX2-2; Sequence=VSP_016345, VSP_016346; Name=3; IsoId=Q8BXX2-3; Sequence=VSP_016344; Widely expressed, with highest levels in white adipose tissue and kidney, intermediate levels in brain, liver and heart, and lowest levels in spleen, brown adipose tissue and muscle. Belongs to the krueppel C2H2-type zinc-finger protein family. transcription coactivator binding nucleic acid binding DNA binding nucleus nucleoplasm cytoplasm cytosol cell cycle cell cycle arrest transcription factor binding negative regulation of cell proliferation microtubule cytoskeleton sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc008xgc.1 uc008xgc.2 uc008xgc.3 
ENSMUST00000094836.6 Stk32b ENSMUST00000094836.6 serine/threonine kinase 32B (from RefSeq NM_022416.3) ENSMUST00000094836.1 ENSMUST00000094836.2 ENSMUST00000094836.3 ENSMUST00000094836.4 ENSMUST00000094836.5 NM_022416 Q7TMD3 Q8C4E0 Q9JJX8 ST32B_MOUSE Stk32 Stk32b uc008xft.1 uc008xft.2 uc008xft.3 uc008xft.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction metal ion binding uc008xft.1 uc008xft.2 uc008xft.3 uc008xft.4 
ENSMUST00000094844.4 Cfap65 ENSMUST00000094844.4 cilia and flagella associated protein 65 (from RefSeq NM_001039495.1) CFA65_MOUSE Ccdc108 Cfap65 ENSMUST00000094844.1 ENSMUST00000094844.2 ENSMUST00000094844.3 NM_001039495 Q3V0B4 uc007bnj.1 uc007bnj.2 uc007bnj.3 Plays a role in flagellar formation and sperm motility. Interacts with CFAP47. Cell projection, cilium, flagellum membrane ; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Single-pass type I membrane protein Cytoplasm Note=Expressed in the cytoplasm of the spermatogonia, round spermatids, early elongating spermatids and late elongating spermatids and in the flagella of epididymal spermatozoa. Predominantly expressed in testis (PubMed:31571197). Highly expressed in round and elongating spermatids (PubMed:31571197, PubMed:31413122). Expressed also in certain ciliated organs, such as the brain, lung and kidney (PubMed:31413122). Begins to be significantly expressed at postnatal day 15, reachs a peak at postnatal day 22 and then maintains stable expression level. Deficient male are infertile whereas female mutants could give birth. Deficient male show severe morphological abnormalities of the sperm flagella. The majority of spermatozoa display absent or short flagella and the flagellar axoneme is completely disorganised. Belongs to the CFAP65 family. cellular_component plasma membrane cilium biological_process membrane integral component of membrane motile cilium cell projection uc007bnj.1 uc007bnj.2 uc007bnj.3 
ENSMUST00000094853.9 Rnf220 ENSMUST00000094853.9 ring finger protein 220, transcript variant 2 (from RefSeq NM_001310729.1) ENSMUST00000094853.1 ENSMUST00000094853.2 ENSMUST00000094853.3 ENSMUST00000094853.4 ENSMUST00000094853.5 ENSMUST00000094853.6 ENSMUST00000094853.7 ENSMUST00000094853.8 NM_001310729 Q9D4L6 Q9D4L6_MOUSE Rnf220 uc008uio.1 uc008uio.2 uc008uio.3 uc008uio.4 ubiquitin-protein transferase activity protein ubiquitination metal ion binding uc008uio.1 uc008uio.2 uc008uio.3 uc008uio.4 
ENSMUST00000094863.6 Vmn2r51 ENSMUST00000094863.6 vomeronasal 2, receptor 51 (from RefSeq NM_001105179.1) ENSMUST00000094863.1 ENSMUST00000094863.2 ENSMUST00000094863.3 ENSMUST00000094863.4 ENSMUST00000094863.5 L7N215 L7N215_MOUSE NM_001105179 Vmn2r51 uc012eyp.1 uc012eyp.2 uc012eyp.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012eyp.1 uc012eyp.2 uc012eyp.3 
ENSMUST00000094866.7 Vmn2r32 ENSMUST00000094866.7 vomeronasal 2, receptor 32 (from RefSeq NM_001105063.1) ENSMUST00000094866.1 ENSMUST00000094866.2 ENSMUST00000094866.3 ENSMUST00000094866.4 ENSMUST00000094866.5 ENSMUST00000094866.6 K7N686 K7N686_MOUSE NM_001105063 Vmn2r32 uc012ext.1 uc012ext.2 uc012ext.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012ext.1 uc012ext.2 uc012ext.3 
ENSMUST00000094868.10 Zfyve28 ENSMUST00000094868.10 zinc finger, FYVE domain containing 28 (from RefSeq NM_001015039.1) B2RSX8 ENSMUST00000094868.1 ENSMUST00000094868.2 ENSMUST00000094868.3 ENSMUST00000094868.4 ENSMUST00000094868.5 ENSMUST00000094868.6 ENSMUST00000094868.7 ENSMUST00000094868.8 ENSMUST00000094868.9 Kiaa1643 LST2_MOUSE Lst2 NM_001015039 Q6ZPK7 uc008xca.1 uc008xca.2 uc008xca.3 Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity). Interacts with TRIM3. Cytoplasm, cytosol. Early endosome membrane. Note=Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated (By similarity). Enriched in brain (at protein level). The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not monoubiquitinated at Lys-87. Monoubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. Belongs to the lst-2 family. Sequence=BAC98224.1; Type=Erroneous initiation; Evidence=; cytoplasm endosome cytosol negative regulation of epidermal growth factor-activated receptor activity membrane early endosome membrane phosphatidylinositol-3-phosphate binding negative regulation of epidermal growth factor receptor signaling pathway metal ion binding uc008xca.1 uc008xca.2 uc008xca.3 
ENSMUST00000094869.12 Nicol1 ENSMUST00000094869.12 NELL2 interacting cell ontogeny regulator 1, transcript variant 1 (from RefSeq NM_001033458.5) B9EJP7 ENSMUST00000094869.1 ENSMUST00000094869.10 ENSMUST00000094869.11 ENSMUST00000094869.2 ENSMUST00000094869.3 ENSMUST00000094869.4 ENSMUST00000094869.5 ENSMUST00000094869.6 ENSMUST00000094869.7 ENSMUST00000094869.8 ENSMUST00000094869.9 Gm1673 NICOL_MOUSE NM_001033458 Q3UR78 Q3V2U0 uc008xbr.1 uc008xbr.2 uc008xbr.3 uc008xbr.4 uc008xbr.5 Testis-derived lumicrine factor that triggers epididymal differentiation and sperm maturation. Interacts with NELL2; triggers epididymal differentiation. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UR78-1; Sequence=Displayed; Name=2; IsoId=Q3UR78-2; Sequence=VSP_034397; Expression is enriched in both male and female reproductive organs, including the testis, epididymis, seminal vesicles, coagulating glands, ovary, and uterus, and in various non- reproductive organs,such as brain, thymus,liver and brain. In testis expressed in both germ cells and Sertoli cells, (PubMed:37095084). Specifically expressed during neocortex and cerebellum development. First expressed in the cerebral cortex after the preplate stage (>E12). At embryonic stage 15.5 dpc and up to 17.5 dpc, it is expressed in cortical plate and in the marginal zone, whereas in adult brain, it is present in all cortical and subcortical regions of the brain. In the developing cerebellum, expressed in the intermediate zone at stage 17.5 dpc, in the molecular layer in newborn, and in the granular as well as molecular layer in adult. In the adult brain, expression in interneurons is also observed (PubMed:21287218). Expression in the testis increases postnatally (PubMed:37095084). Deficient males are sterile, whereas females are fertile. Deficient mice display defective sperm migration from the uterus into the oviduct and poor sperm binding to the egg zona pellucida. Mice are infertile because of deficient epididymal differentiation and deficient sperm maturation. Sequence=AAI47445.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI47469.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE24810.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component extracellular region biological_process uc008xbr.1 uc008xbr.2 uc008xbr.3 uc008xbr.4 uc008xbr.5 
ENSMUST00000094870.3 Zfp787 ENSMUST00000094870.3 zinc finger protein 787, transcript variant 1 (from RefSeq NM_001379300.1) B9EHE2 ENSMUST00000094870.1 ENSMUST00000094870.2 NM_001379300 Q8BIF9 ZN787_MOUSE Znf787 uc009fap.1 uc009fap.2 uc009fap.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC36810.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding nucleus biological_process metal ion binding uc009fap.1 uc009fap.2 uc009fap.3 
ENSMUST00000094887.4 Cyp4a12b ENSMUST00000094887.4 cytochrome P450, family 4, subfamily a, polypeptide 12B (from RefSeq NM_172306.2) A2A974 CP4CB_MOUSE Cyp4a12b ENSMUST00000094887.1 ENSMUST00000094887.2 ENSMUST00000094887.3 NM_172306 uc008ues.1 uc008ues.2 A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:17112342). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:17112342). Catalyzes predominantly the oxidation of the terminal carbon (omega- oxidation) of saturated and unsaturated fatty acids (PubMed:17112342). May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney (PubMed:17112342). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20- hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:17112342). Acts as an omega-hydroxylase and epoxidase toward (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoc acid (EPA). Catalyzes the epoxidation of the last double bond of EPA with no preferred stereoselectivity, producing both (R,S) and (S,R) stereoisomers (PubMed:17112342). Can also catalyze the omega-1 and omega-2 oxidation of fatty acids with lower efficiency (PubMed:17112342). Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence=; Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39751, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76628; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39752; Evidence=; Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38947, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:36204, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38948; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39811, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:63590; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39812; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39759, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76627; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39760; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39755, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76624; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39756; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)- eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39787, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76636; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39788; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)- eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39791, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76639; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39792; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)- eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39783, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76635; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39784; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)- eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39779, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76634; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39780; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Activated by cytochrome b5. The Vmax almost doubles in the presence of cytochrome b5. Kinetic parameters: KM=2 uM for dodecanoic acid ; KM=43 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (without cytochrome b5) ; KM=72 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (with cytochrome b5) ; KM=41 uM for (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoic acid (without cytochrome b5) ; KM=62 uM for (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoic acid (with cytochrome b5) ; Vmax=40 nmol/min/nmol enzyme toward dodecanoic acid ; Vmax=10 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (without cytochrome b5) ; Vmax=19 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (with cytochrome b5) ; Vmax=15 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z,17Z)- eicosapentaenoic acid (without cytochrome b5) ; Vmax=30 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z,17Z)- eicosapentaenoic acid (with cytochrome b5) ; Lipid metabolism; fatty acid metabolism. Endoplasmic reticulum membrane ; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein. Expressed in lung, but almost undetectable in the kidneys of five different strains. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding extracellular space oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc008ues.1 uc008ues.2 
ENSMUST00000094892.12 Il11 ENSMUST00000094892.12 interleukin 11, transcript variant 1 (from RefSeq NM_008350.5) ENSMUST00000094892.1 ENSMUST00000094892.10 ENSMUST00000094892.11 ENSMUST00000094892.2 ENSMUST00000094892.3 ENSMUST00000094892.4 ENSMUST00000094892.5 ENSMUST00000094892.6 ENSMUST00000094892.7 ENSMUST00000094892.8 ENSMUST00000094892.9 IL11_MOUSE Il11 NM_008350 P47873 uc009eyo.1 uc009eyo.2 uc009eyo.3 uc009eyo.4 Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed:22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed:10026196, PubMed:23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed:23948300, PubMed:22253262). The interaction with the membrane- bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans- signaling' (By similarity). Interacts with either IL11RA1 or IL11RA2 to associate with IL6ST, giving rise to a multimeric signaling complex. Secreted Up-regulated in hepatocytes by oxidative stress caused by liver damage. Belongs to the IL-6 superfamily. cytokine activity interleukin-11 receptor binding extracellular region extracellular space cytoplasm signal transduction growth factor activity positive regulation of cell proliferation positive regulation of peptidyl-serine phosphorylation positive regulation of MAPK cascade positive regulation of transcription from RNA polymerase II promoter negative regulation of hormone secretion positive regulation of peptidyl-tyrosine phosphorylation uc009eyo.1 uc009eyo.2 uc009eyo.3 uc009eyo.4 
ENSMUST00000094894.4 Trabd2b ENSMUST00000094894.4 TraB domain containing 2B (from RefSeq NM_001085549.1) B1ATG9 ENSMUST00000094894.1 ENSMUST00000094894.2 ENSMUST00000094894.3 Gm12824 Hkat NM_001085549 TIKI2_MOUSE Tiki2 uc008ueb.1 uc008ueb.2 Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation (By similarity). Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Note=Divalent metal cations. Mn(2+) or Co(2+). ; Cell membrane ; Single-pass type I membrane protein Highly expressed in heart and kidney. Also found in white and brown adipose tissue. Transiently induced during 3T3-L1 cell differentiation into adipocytes. In vivo, down-regulated by fasting in both white and brown adipose tissues. High-fat diet down-regulates expression in white adipose tissue and up-regulates it in brown adipose tissue. Belongs to the TIKI family. metalloendopeptidase activity plasma membrane integral component of plasma membrane proteolysis peptidase activity metallopeptidase activity membrane integral component of membrane Wnt signaling pathway hydrolase activity Wnt-protein binding negative regulation of Wnt signaling pathway integral component of organelle membrane positive regulation of protein complex assembly positive regulation of protein oligomerization metal ion binding positive regulation of protein oxidation uc008ueb.1 uc008ueb.2 
ENSMUST00000094897.5 Dnaaf3 ENSMUST00000094897.5 dynein, axonemal assembly factor 3 (from RefSeq NM_001033548.3) B2RX55 DAAF3_MOUSE ENSMUST00000094897.1 ENSMUST00000094897.2 ENSMUST00000094897.3 ENSMUST00000094897.4 NM_001033548 Q3UYV8 uc009exw.1 uc009exw.2 uc009exw.3 Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia (By similarity). Cytoplasm Dynein axonemal particle Belongs to the DNAAF3 family. molecular_function cellular_component cytoplasm determination of left/right symmetry heart development cell projection organization motile cilium assembly axonemal dynein complex assembly uc009exw.1 uc009exw.2 uc009exw.3 
ENSMUST00000094898.5 Ccnyl1 ENSMUST00000094898.5 cyclin Y-like 1 (from RefSeq NM_001097644.1) ENSMUST00000094898.1 ENSMUST00000094898.2 ENSMUST00000094898.3 ENSMUST00000094898.4 NM_001097644 uc287iui.1 uc287iui.2 uc287iui.1 uc287iui.2 
ENSMUST00000094916.5 Ldlrad1 ENSMUST00000094916.5 low density lipoprotein receptor class A domain containing 1 (from RefSeq NM_001081272.2) D3YYZ1 D3YYZ1_MOUSE ENSMUST00000094916.1 ENSMUST00000094916.2 ENSMUST00000094916.3 ENSMUST00000094916.4 Ldlrad1 NM_001081272 uc008tzk.1 uc008tzk.2 uc008tzk.3 Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function cellular_component biological_process membrane integral component of membrane uc008tzk.1 uc008tzk.2 uc008tzk.3 
ENSMUST00000094933.6 Usp24 ENSMUST00000094933.6 ubiquitin specific peptidase 24 (from RefSeq NM_183225.2) B1AY13 ENSMUST00000094933.1 ENSMUST00000094933.2 ENSMUST00000094933.3 ENSMUST00000094933.4 ENSMUST00000094933.5 NM_183225 Q8BLI7 UBP24_MOUSE uc008tyh.1 uc008tyh.2 uc008tyh.3 uc008tyh.4 uc008tyh.5 Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B1AY13-1; Sequence=Displayed; Name=2; IsoId=B1AY13-2; Sequence=VSP_035661, VSP_035662; Belongs to the peptidase C19 family. cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity uc008tyh.1 uc008tyh.2 uc008tyh.3 uc008tyh.4 uc008tyh.5 
ENSMUST00000094934.11 Gad1 ENSMUST00000094934.11 glutamate decarboxylase 1, transcript variant 12 (from RefSeq NR_185135.1) ENSMUST00000094934.1 ENSMUST00000094934.10 ENSMUST00000094934.2 ENSMUST00000094934.3 ENSMUST00000094934.4 ENSMUST00000094934.5 ENSMUST00000094934.6 ENSMUST00000094934.7 ENSMUST00000094934.8 ENSMUST00000094934.9 Gad1 NR_185135 Q548L6 Q548L6_MOUSE gad67 uc008jzk.1 uc008jzk.2 uc008jzk.3 uc008jzk.4 Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor. Reaction=H(+) + L-glutamate = 4-aminobutanoate + CO2; Xref=Rhea:RHEA:17785, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29985, ChEBI:CHEBI:59888; EC=4.1.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17786; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence= Homodimer. Belongs to the group II decarboxylase family. catalytic activity glutamate decarboxylase activity gamma-aminobutyric acid biosynthetic process glutamate binding lyase activity carboxy-lyase activity carboxylic acid metabolic process pyridoxal phosphate binding response to drug protein heterodimerization activity protein N-terminus binding presynaptic active zone uc008jzk.1 uc008jzk.2 uc008jzk.3 uc008jzk.4 
ENSMUST00000094942.4 Cfap210 ENSMUST00000094942.4 cilia and flagella associated protein 210, transcript variant 4 (from RefSeq NR_184818.1) A0JLY1 CF210_MOUSE Ccdc173 ENSMUST00000094942.1 ENSMUST00000094942.2 ENSMUST00000094942.3 NR_184818 uc008jyo.1 uc008jyo.2 uc008jyo.3 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Cytoplasm, cytoskeleton, cilium axoneme molecular_function cellular_component biological_process uc008jyo.1 uc008jyo.2 uc008jyo.3 
ENSMUST00000094946.5 Speer4a2 ENSMUST00000094946.5 spermatogenesis associated glutamate (E)-rich protein 4A2 (from RefSeq NM_001177579.1) E9Q1C7 E9Q1C7_MOUSE ENSMUST00000094946.1 ENSMUST00000094946.2 ENSMUST00000094946.3 ENSMUST00000094946.4 Gm10471 NM_001177579 uc012dtn.1 uc012dtn.2 uc012dtn.3 molecular_function cellular_component biological_process uc012dtn.1 uc012dtn.2 uc012dtn.3 
ENSMUST00000094955.3 Gm12689 ENSMUST00000094955.3 Gm12689 (from geneSymbol) AK046412 ENSMUST00000094955.1 ENSMUST00000094955.2 uc290nzv.1 uc290nzv.2 uc290nzv.1 uc290nzv.2 
ENSMUST00000094962.9 Kmt2e ENSMUST00000094962.9 lysine (K)-specific methyltransferase 2E (from RefSeq NM_026984.2) ENSMUST00000094962.1 ENSMUST00000094962.2 ENSMUST00000094962.3 ENSMUST00000094962.4 ENSMUST00000094962.5 ENSMUST00000094962.6 ENSMUST00000094962.7 ENSMUST00000094962.8 KMT2E_MOUSE Mll5 NM_026984 Q3SYI5 Q3TUY2 Q3UG20 Q3V410 Q5FWI1 Q6P3B3 Q8BS65 Q8CFX7 Q9CVK6 uc008wqa.1 uc008wqa.2 uc008wqa.3 uc008wqa.4 Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (By similarity). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (By similarity). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (PubMed:18854576, PubMed:18952892, PubMed:18818388). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:19264965). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (By similarity). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (PubMed:19264965). Component of a complex composed of KMT2E, OGT and USP7; the complex stabilizes KMT2E, preventing KMT2E ubiquitination and proteasomal-mediated degradation. Interacts (via N-terminus) with OGT (via TRP repeats). Interacts with deubiquitinating enzyme USP7 (via MATH domain). Interacts (via HBM motif) with HCFC1 (via Kelch domain). Interacts with E2F1; the interaction is probably indirect and is mediated via HCFC1. Chromosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus speckle Note=Absent from the nucleolus. Localizes to chromosome during interphase and to centrosomes during mitosis. Dissociation from mitotic chromosome is likely due to histone H3 phosphorylation on 'Thr-3' and 'Thr-6'. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q3UG20-1; Sequence=Displayed; Name=2 ; IsoId=Q3UG20-2; Sequence=VSP_052813; Up-regulated in reversibly arrested C2C12 myoblasts. The PHD-type domain binds specifically histone H3 tri- methylated at 'Lys-4' (H3K4me3), thus promoting binding to chromatin. The SET domain does not bind the methyl group donor S-adenosyl- L-methionine and histone 3 H3K4 peptide as a large loop prevents the docking of the 'Lys-4' side chain. The C-terminus domain is responsible for the localization to the centrosome during mitosis. Ubiquitinated. Deubiquitinated by USP7. O-glycosylated at Ser-435 and Thr-440 in the SET domain by OGT which probably prevents KMT2E proteasomal-mediated degradation. Defects in immunity and hematopoiesis. Adult homozygous mice are obtained at reduced frequency because of postnatal lethality. Surviving animals display a variety of abnormalities, including male infertility, retarded growth and defects in multiple hematopoietic lineages. They also show increased susceptibility to spontaneous eye infections associated with a cell-autonomous impairment of neutrophil function. They exhibit a mild impairment of erythropoiesis and hematopoietic stem cells (HSCs) have impaired competitive repopulating capacity both under normal conditions and when subjected to self-renewal stimulation by NUP98-HOXA10. Homozygous HSCs show a dramatic sensitivity to DNA demethylation-induced differentiation (5-azadeoxycytidine). Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. Does not exhibit histone methyltransferase towards histone H3 in vitro (PubMed:18952892). The isolated catalytic SET domain lacks binding activity towards cofactor S-adenosyl-L-methionine; instead of the highly conserved XGXG, Y and NH motifs, KMT2E displays NKKI (Asn- 339-Ile-342), F (Phe-381) and RR (Arg-408-Arg-409) motifs. Also lacks binding activity towards histone H3 due to a poor conservation of the key residues involved in the binding and the presence of large loop which prevents the docking of the H3 'Lys-4' side chain. Sequence=AAH36286.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 486.; Evidence=; Sequence=AAH64079.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 803.; Evidence=; Sequence=AAH89356.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 495.; Evidence=; Sequence=AAI03802.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 492.; Evidence=; Sequence=BAB25186.1; Type=Erroneous initiation; Evidence=; Sequence=BAC28936.2; Type=Erroneous initiation; Evidence=; Sequence=BAE28389.1; Type=Frameshift; Evidence=; chromatin neutrophil mediated immunity transcription coactivator activity nucleus chromosome cytoplasm microtubule organizing center cytoskeleton DNA methylation chromatin organization cell cycle cell cycle arrest nuclear speck enzyme binding erythrocyte differentiation macromolecular complex methylated histone binding transcriptionally active chromatin neutrophil activation histone methyltransferase activity (H3-K4 specific) positive regulation of transcription, DNA-templated metal ion binding retinoic acid receptor signaling pathway histone H3-K4 methylation positive regulation of G1/S transition of mitotic cell cycle positive regulation of histone H3-K4 trimethylation uc008wqa.1 uc008wqa.2 uc008wqa.3 uc008wqa.4 
ENSMUST00000094964.7 Dnah7a ENSMUST00000094964.7 dynein, axonemal, heavy chain 7A (from RefSeq NM_001252070.1) Dnah7a Dnahc7a Dnahc7b E9Q0T8 E9Q0T8_MOUSE ENSMUST00000094964.1 ENSMUST00000094964.2 ENSMUST00000094964.3 ENSMUST00000094964.4 ENSMUST00000094964.5 ENSMUST00000094964.6 NM_001252070 uc029qom.1 uc029qom.2 uc029qom.3 Belongs to the dynein heavy chain family. cilium movement microtubule motor activity calcium ion binding ATP binding cytosol cilium microtubule-based movement ATP-dependent microtubule motor activity, minus-end-directed dynein complex inner dynein arm dynein intermediate chain binding dynein light intermediate chain binding uc029qom.1 uc029qom.2 uc029qom.3 
ENSMUST00000094972.2 Ifna1 ENSMUST00000094972.2 interferon alpha 1 (from RefSeq NM_010502.2) ENSMUST00000094972.1 IFNA1_MOUSE NM_010502 P01572 Q7M0A3 Q810G7 uc008toc.1 uc008toc.2 Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Secreted. Glycosylated. Belongs to the alpha/beta interferon family. Was named interferon alpha-E (embryonic) based on peptide sequencing (PubMed:9244179). The differences found may be sequencing erros and have not been confirmed by other studies. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation defense response to bacterium response to exogenous dsRNA regulation of defense response to virus by host defense response to virus type I interferon signaling pathway uc008toc.1 uc008toc.2 
ENSMUST00000094973.5 Ifna4 ENSMUST00000094973.5 interferon alpha 4 (from RefSeq NM_010504.3) ENSMUST00000094973.1 ENSMUST00000094973.2 ENSMUST00000094973.3 ENSMUST00000094973.4 If1ai13 Ifna4 NM_010504 Q540C2 Q540C2_MOUSE uc008tob.1 uc008tob.2 uc008tob.3 uc008tob.4 Secreted Belongs to the alpha/beta interferon family. cytokine activity cytokine receptor binding extracellular region extracellular space defense response signal transduction defense response to virus uc008tob.1 uc008tob.2 uc008tob.3 uc008tob.4 
ENSMUST00000094977.2 Gm13288 ENSMUST00000094977.2 predicted gene 13288 (from RefSeq NM_001243167.1) B1AYI0 ENSMUST00000094977.1 Gm13277 Gm13278 Gm13279 Gm13288 Gm13289 Gm13290 NM_001243167 Q8CD73 Q8CD73_MOUSE uc008tnw.1 uc008tnw.2 uc008tnw.3 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tnw.1 uc008tnw.2 uc008tnw.3 
ENSMUST00000094992.2 Gm13271 ENSMUST00000094992.2 predicted gene 13271 (from RefSeq NM_001085528.1) B1AYH9 B1AYH9_MOUSE ENSMUST00000094992.1 Gm13271 If1ha1 NM_001085528 uc008tnl.1 uc008tnl.2 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tnl.1 uc008tnl.2 
ENSMUST00000094993.3 Klhl9 ENSMUST00000094993.3 kelch-like 9 (from RefSeq NM_172871.2) ENSMUST00000094993.1 ENSMUST00000094993.2 KLHL9_MOUSE Kiaa1354 NM_172871 Q505G5 Q6ZPT1 uc008tnk.1 uc008tnk.2 uc008tnk.3 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity). Protein modification; protein ubiquitination. Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB (By similarity). Sequence=BAC98148.1; Type=Erroneous initiation; Evidence=; ubiquitin-protein transferase activity cell cycle protein ubiquitination midbody Cul3-RING ubiquitin ligase complex regulation of cytokinesis cell division uc008tnk.1 uc008tnk.2 uc008tnk.3 
ENSMUST00000095004.4 Gm7347 ENSMUST00000095004.4 predicted gene 7347, transcript variant 2 (from RefSeq NM_001378636.1) D3YYI9 D3YYI9_MOUSE ENSMUST00000095004.1 ENSMUST00000095004.2 ENSMUST00000095004.3 Gm7347 NM_001378636 uc290tvb.1 uc290tvb.2 molecular_function cellular_component biological_process uc290tvb.1 uc290tvb.2 
ENSMUST00000095005.12 Speer4c1 ENSMUST00000095005.12 spermatogenesis associated glutamate (E)-rich protein 4C1 (from RefSeq NM_001281511.1) ENSMUST00000095005.1 ENSMUST00000095005.10 ENSMUST00000095005.11 ENSMUST00000095005.2 ENSMUST00000095005.3 ENSMUST00000095005.4 ENSMUST00000095005.5 ENSMUST00000095005.6 ENSMUST00000095005.7 ENSMUST00000095005.8 ENSMUST00000095005.9 G3UXD1 G3UXD1_MOUSE NM_001281511 Speer4c uc008wmt.1 uc008wmt.2 uc008wmt.3 uc008wmt.4 molecular_function cellular_component biological_process uc008wmt.1 uc008wmt.2 uc008wmt.3 uc008wmt.4 
ENSMUST00000095006.9 Speer4d ENSMUST00000095006.9 spermatogenesis associated glutamate (E)-rich protein 4D (from RefSeq NM_025759.3) ENSMUST00000095006.1 ENSMUST00000095006.2 ENSMUST00000095006.3 ENSMUST00000095006.4 ENSMUST00000095006.5 ENSMUST00000095006.6 ENSMUST00000095006.7 ENSMUST00000095006.8 L7N216 L7N216_MOUSE NM_025759 Speer4d uc008wmr.1 uc008wmr.2 uc008wmr.3 molecular_function nucleus biological_process uc008wmr.1 uc008wmr.2 uc008wmr.3 
ENSMUST00000095012.11 Sema3a ENSMUST00000095012.11 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, transcript variant 2 (from RefSeq NM_001243072.1) A0A803Z7F8 A0A803Z7F8_MOUSE ENSMUST00000095012.1 ENSMUST00000095012.10 ENSMUST00000095012.2 ENSMUST00000095012.3 ENSMUST00000095012.4 ENSMUST00000095012.5 ENSMUST00000095012.6 ENSMUST00000095012.7 ENSMUST00000095012.8 ENSMUST00000095012.9 NM_001243072 Sema3a mCG_16225 uc029vfv.1 uc029vfv.2 uc029vfv.3 Secreted Belongs to the semaphorin family. Lacks conserved residue(s) required for the propagation of feature annotation. uc029vfv.1 uc029vfv.2 uc029vfv.3 
ENSMUST00000095014.8 Tgfbrap1 ENSMUST00000095014.8 transforming growth factor, beta receptor associated protein 1, transcript variant 1 (from RefSeq NM_001013025.3) ENSMUST00000095014.1 ENSMUST00000095014.2 ENSMUST00000095014.3 ENSMUST00000095014.4 ENSMUST00000095014.5 ENSMUST00000095014.6 ENSMUST00000095014.7 NM_001013025 Q3UR70 Q8BKN4 TGFA1_MOUSE uc007avf.1 uc007avf.2 uc007avf.3 Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 (By similarity). Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (By similarity). Interacts with TGFBR2 and ACVR2B; in the absence of ligand stimulation. Interacts with TGFBR1, ACVRL1, BMPR1A and ACVR1B; in the absence of ligand stimulation and to a less extent. Interacts with SMAD4; the interaction seems to be mutually exclusive with the interaction of SMAD4 and phosphorylated SMAD2. May interact with ALOX5 (By similarity). Interacts with RAB5C. Interacts with VPS8, VPS11 and VPS16. Component of the putative class C core vacuole/endosome tethering (CORVET) complex; the core of which composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, is associated with VPS8 and TGFBRAP1 (PubMed:25266290). Cytoplasm. Early endosome Note=Colocalizes with TGF-beta receptors in the absence of signaling. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UR70-1; Sequence=Displayed; Name=2; IsoId=Q3UR70-2; Sequence=VSP_034944, VSP_034945; Embryonic lethal, both before blastula stage or during gastrulation. Belongs to the TRAP1 family. transforming growth factor beta receptor binding cytoplasm endosome early endosome regulation of transcription, DNA-templated intracellular protein transport signal transduction endosome to lysosome transport protein transport membrane vesicle-mediated transport CORVET complex endosomal vesicle fusion intracellular membrane-bounded organelle SMAD binding uc007avf.1 uc007avf.2 uc007avf.3 
ENSMUST00000095015.12 Gm6455 ENSMUST00000095015.12 Gm6455 (from geneSymbol) BC048648 ENSMUST00000095015.1 ENSMUST00000095015.10 ENSMUST00000095015.11 ENSMUST00000095015.2 ENSMUST00000095015.3 ENSMUST00000095015.4 ENSMUST00000095015.5 ENSMUST00000095015.6 ENSMUST00000095015.7 ENSMUST00000095015.8 ENSMUST00000095015.9 uc008wln.1 uc008wln.2 uc008wln.3 uc008wln.4 uc008wln.1 uc008wln.2 uc008wln.3 uc008wln.4 
ENSMUST00000095021.2 Or1ak2 ENSMUST00000095021.2 olfactory receptor family 1 subfamily AK member 2 (from RefSeq NM_146624.1) ENSMUST00000095021.1 NM_146624 Olfr356 Or1ak2 Q8VFP5 Q8VFP5_MOUSE uc008jmf.1 uc008jmf.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC129799.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008jmf.1 uc008jmf.2 
ENSMUST00000095023.2 2310002L09Rik ENSMUST00000095023.2 RIKEN cDNA 2310002L09 gene, transcript variant 1 (from RefSeq NM_027981.1) 2310002L09Rik ENSMUST00000095023.1 NM_027981 Q9D7L5 Q9D7L5_MOUSE uc012dgh.1 uc012dgh.2 uc012dgh.3 mitochondrion membrane integral component of membrane actomyosin structure organization uc012dgh.1 uc012dgh.2 uc012dgh.3 
ENSMUST00000095049.5 Mup15 ENSMUST00000095049.5 major urinary protein 15 (from RefSeq NM_001200004.1) A9R9W0 A9R9W0_MOUSE ENSMUST00000095049.1 ENSMUST00000095049.2 ENSMUST00000095049.3 ENSMUST00000095049.4 Mup15 NM_001200004 uc012dfk.1 uc012dfk.2 uc012dfk.3 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc012dfk.1 uc012dfk.2 uc012dfk.3 
ENSMUST00000095058.5 Mup8 ENSMUST00000095058.5 major urinary protein 8 (from RefSeq NM_001347131.1) A2AKN8 A2AKN8_MOUSE ENSMUST00000095058.1 ENSMUST00000095058.2 ENSMUST00000095058.3 ENSMUST00000095058.4 Mup5 Mup8 NM_001347131 OTTMUSG00000008509 uc290nak.1 uc290nak.2 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc290nak.1 uc290nak.2 
ENSMUST00000095062.10 Lmbrd1 ENSMUST00000095062.10 LMBR1 domain containing 1, transcript variant 2 (from RefSeq NM_001310483.1) ENSMUST00000095062.1 ENSMUST00000095062.2 ENSMUST00000095062.3 ENSMUST00000095062.4 ENSMUST00000095062.5 ENSMUST00000095062.6 ENSMUST00000095062.7 ENSMUST00000095062.8 ENSMUST00000095062.9 LMBD1_MOUSE Lmbrd1 NM_001310483 Q3U696 Q8CCL7 Q8K0B2 Q8R3D6 Q8VH50 Q9CW67 uc007amu.1 uc007amu.2 uc007amu.3 uc007amu.4 Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (PubMed:24078630). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (PubMed:24078630). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (PubMed:27061115). Interacts with ABCD4; this interaction induces the translocation of ABCD4 from the endoplasmic reticulum to the lysosome. Interacts with ABCD4 and MMACHC; this interaction ensures the transport of cobalamin from the lysosome to the cytoplasm (By similarity). Interacts with INSR, adapter protein complex 2 and clathrin heavy chain (PubMed:24078630). Endoplasmic reticulum membrane Lysosome membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle, clathrin-coated vesicle Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K0B2-1; Sequence=Displayed; Name=2; IsoId=Q8K0B2-2; Sequence=VSP_021632, VSP_021633; Name=3; IsoId=Q8K0B2-3; Sequence=VSP_021631; Ubiquitously expressed with strong signals in the primitive streak and in extraembryonic tissues at 7.5 dpc (PubMed:27061115). During further development, expression is strongest in the neuronal fold at 8.5 dpc (PubMed:27061115). N-glycosylated. Early embryonic lethality (PubMed:27061115). Embryos show an impaired initiation of gastrulation (PubMed:27061115). Belongs to the LIMR family. LMBRD1 subfamily. insulin receptor binding lysosome lysosomal membrane plasma membrane membrane integral component of membrane cobalamin binding insulin receptor internalization clathrin-coated endocytic vesicle negative regulation of glucose import negative regulation of insulin receptor signaling pathway negative regulation of protein kinase B signaling regulation of MAPK cascade uc007amu.1 uc007amu.2 uc007amu.3 uc007amu.4 
ENSMUST00000095063.11 Inip ENSMUST00000095063.11 INTS3 and NABP interacting protein (from RefSeq NM_001013577.1) B1AX81 B1AX82 ENSMUST00000095063.1 ENSMUST00000095063.10 ENSMUST00000095063.2 ENSMUST00000095063.3 ENSMUST00000095063.4 ENSMUST00000095063.5 ENSMUST00000095063.6 ENSMUST00000095063.7 ENSMUST00000095063.8 ENSMUST00000095063.9 NM_001013577 Q3TEN1 Q3TXT3 Q8BTC7 SOSSC_MOUSE Ssbip1 uc008tac.1 uc008tac.2 uc008tac.3 uc008tac.4 Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). Component of the SOSS complex, composed of SOSS-B (SOSS- B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Interacts with INTS3; the interaction is direct (By similarity). Nucleus Note=Localizes to nuclear foci following DNA damage. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TXT3-1; Sequence=Displayed; Name=2; IsoId=Q3TXT3-2; Sequence=VSP_023425; Belongs to the SOSS-C family. Sequence=BAC25075.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE41217.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAM21913.1; Type=Erroneous gene model prediction; Evidence=; molecular_function nucleus nucleoplasm DNA repair cellular response to DNA damage stimulus response to ionizing radiation SOSS complex uc008tac.1 uc008tac.2 uc008tac.3 uc008tac.4 
ENSMUST00000095070.4 Dnajc25 ENSMUST00000095070.4 DnaJ heat shock protein family (Hsp40) member C25 (from RefSeq NM_001033165.3) A2ALW4 A2ALW5 DJC25_MOUSE ENSMUST00000095070.1 ENSMUST00000095070.2 ENSMUST00000095070.3 NM_001033165 Q0VBC8 Q3UWH0 uc008szn.1 uc008szn.2 uc008szn.3 uc008szn.4 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2ALW5-1; Sequence=Displayed; Name=2; IsoId=A2ALW5-2; Sequence=VSP_035183; Belongs to the DNAJC25 family. Sequence=BAE22945.1; Type=Erroneous initiation; Evidence=; Sequence=CAM17653.1; Type=Erroneous gene model prediction; Evidence=; protein folding membrane integral component of membrane uc008szn.1 uc008szn.2 uc008szn.3 uc008szn.4 
ENSMUST00000095074.4 Paqr7 ENSMUST00000095074.4 progestin and adipoQ receptor family member VII, transcript variant 4 (from RefSeq NM_027995.4) ENSMUST00000095074.1 ENSMUST00000095074.2 ENSMUST00000095074.3 Mpra NM_027995 PAQR7_MOUSE Paqr7 Pglp Q3TDA0 Q80ZE4 Q8BNZ7 Q9D790 uc008vff.1 uc008vff.2 uc008vff.3 uc008vff.4 Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved in neurosteroid inhibition of apoptosis. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone. Cell membrane ; Multi-pass membrane protein Detected in most adult tissues. Higher expression found in white fat and liver than brown fat and skeletal muscle. Up-regulated in PPAR gamma 1-induced adipogenic liver. Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). Belongs to the ADIPOR family. steroid hormone receptor activity steroid binding plasma membrane multicellular organism development lipid binding membrane integral component of membrane cell differentiation signaling receptor activity steroid hormone mediated signaling pathway oogenesis response to steroid hormone uc008vff.1 uc008vff.2 uc008vff.3 uc008vff.4 
ENSMUST00000095075.5 Crispld1 ENSMUST00000095075.5 cysteine-rich secretory protein LCCL domain containing 1, transcript variant 1 (from RefSeq NM_031402.3) CRLD1_MOUSE ENSMUST00000095075.1 ENSMUST00000095075.2 ENSMUST00000095075.3 ENSMUST00000095075.4 NM_031402 Q8CGD2 Q8K018 Q99MM6 uc007akh.1 uc007akh.2 uc007akh.3 Secreted Belongs to the CRISP family. Sequence=AAK16496.1; Type=Frameshift; Evidence=; molecular_function extracellular region extracellular space face morphogenesis uc007akh.1 uc007akh.2 uc007akh.3 
ENSMUST00000095076.10 Epb41l4b ENSMUST00000095076.10 erythrocyte membrane protein band 4.1 like 4b, transcript variant 3 (from RefSeq NM_001424796.1) A2ALK6 A2ALK6_MOUSE ENSMUST00000095076.1 ENSMUST00000095076.2 ENSMUST00000095076.3 ENSMUST00000095076.4 ENSMUST00000095076.5 ENSMUST00000095076.6 ENSMUST00000095076.7 ENSMUST00000095076.8 ENSMUST00000095076.9 Epb4.1l4b Epb41l4b NM_001424796 uc057brv.1 uc057brv.2 uc057brv.3 cytoskeleton cytoskeletal protein binding uc057brv.1 uc057brv.2 uc057brv.3 
ENSMUST00000095079.6 Actl7a ENSMUST00000095079.6 actin-like 7a (from RefSeq NM_009611.3) A2AMK4 ACL7A_MOUSE ENSMUST00000095079.1 ENSMUST00000095079.2 ENSMUST00000095079.3 ENSMUST00000095079.4 ENSMUST00000095079.5 NM_009611 Q9D9P4 Q9JMI5 Q9QY84 Tact2 uc008sxo.1 uc008sxo.2 uc008sxo.3 uc008sxo.4 May play an important role in formation and fusion of Golgi- derived vesicles during acrosome biogenesis. Interacts (via N-terminus) with TES (via LIM domain 2). Heterodimer with TES; the heterodimer interacts with ENAH to form a heterotrimer. Interacts with ACTL9. Cytoplasm, cytoskeleton Golgi apparatus Cytoplasm Nucleus Cytoplasmic vesicle, secretory vesicle, acrosome Note=Detected at the Golgi apparatus during acrosome biogenesis (PubMed:21278383). Detected at the subacrosomal layer in round spermatids (PubMed:21278383). Detected in sperm head and tail (PubMed:21278383). Detected in testis. Detected at the acrosome of round spermatids (at protein level). Detected in adult and embryonic testis. Detected in developing male germ cells. Belongs to the actin family. male germ cell nucleus nucleus cytoplasm Golgi apparatus cytoskeleton actin cytoskeleton motile cilium macromolecular complex uc008sxo.1 uc008sxo.2 uc008sxo.3 uc008sxo.4 
ENSMUST00000095080.5 Actl7b ENSMUST00000095080.5 actin-like 7b (from RefSeq NM_025271.2) ACL7B_MOUSE ENSMUST00000095080.1 ENSMUST00000095080.2 ENSMUST00000095080.3 ENSMUST00000095080.4 NM_025271 Q14AJ4 Q9JMI6 Q9QY83 Tact1 uc008sxn.1 uc008sxn.2 uc008sxn.3 Cytoplasm, cytoskeleton Testis specific. Belongs to the actin family. nucleus cytoplasm cytoskeleton actin cytoskeleton uc008sxn.1 uc008sxn.2 uc008sxn.3 
ENSMUST00000095085.2 Or13f5 ENSMUST00000095085.2 olfactory receptor family 13 subfamily F member 5 (from RefSeq NM_146858.2) ENSMUST00000095085.1 NM_146858 Olfr275 Or13f5 Q7TS18 Q7TS18_MOUSE uc008swo.1 uc008swo.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC101951.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. dopamine neurotransmitter receptor activity, coupled via Gi/Go synaptic transmission, dopaminergic G-protein coupled receptor activity adrenergic receptor activity olfactory receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway sensory perception of smell response to toxic substance regulation of dopamine secretion membrane integral component of membrane synaptic vesicle membrane dopamine binding response to drug regulation of potassium ion transport behavioral response to cocaine behavioral response to ethanol response to stimulus detection of chemical stimulus involved in sensory perception of smell negative regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway negative regulation of synaptic transmission, glutamatergic phospholipase C-activating dopamine receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway negative regulation of voltage-gated calcium channel activity uc008swo.1 uc008swo.2 
ENSMUST00000095086.3 Acnat1 ENSMUST00000095086.3 acyl-coenzyme A amino acid N-acyltransferase 1 (from RefSeq NM_001164565.1) A2AKK4 A2AKK5 ACNT1_MOUSE Acnat1 ENSMUST00000095086.1 ENSMUST00000095086.2 NM_001164565 Q0QBA1 uc008svr.1 uc008svr.2 uc008svr.3 uc008svr.4 Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine (PubMed:17116739). Shows no conjugation activity in the presence of glycine (PubMed:17116739). Reaction=taurine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl- taurine; Xref=Rhea:RHEA:50120, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:132049, ChEBI:CHEBI:507393; Evidence=; Reaction=eicosanoyl-CoA + taurine = CoA + H(+) + N-eicosanoyl-taurine; Xref=Rhea:RHEA:50116, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:132048, ChEBI:CHEBI:507393; Evidence=; Reaction=octadecanoyl-CoA + taurine = CoA + H(+) + N-octadecanoyl- taurine; Xref=Rhea:RHEA:50112, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:132047, ChEBI:CHEBI:507393; Evidence=; Reaction=hexadecanoyl-CoA + taurine = CoA + H(+) + N-hexadecanoyl- taurine; Xref=Rhea:RHEA:50108, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:132045, ChEBI:CHEBI:507393; Evidence=; Reaction=taurine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoyl- taurine; Xref=Rhea:RHEA:50104, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:132043, ChEBI:CHEBI:507393; Evidence=; Reaction=dodecanoyl-CoA + taurine = CoA + H(+) + N-dodecanoyl-taurine; Xref=Rhea:RHEA:50100, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:132042, ChEBI:CHEBI:507393; Evidence=; Kinetic parameters: KM=11 uM for C16:0-coenzyme A ; Vmax=159.5 nmol/min/mg enzyme ; Peroxisome Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=A2AKK5-1; Sequence=Displayed; Name=2; IsoId=A2AKK5-2; Sequence=VSP_052953; Expressed mainly in liver and kidney with low levels in adrenal and little or no expression in other tissues. Belongs to the C/M/P thioester hydrolase family. peroxisome lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process N-acyltransferase activity transferase activity transferase activity, transferring acyl groups thiolester hydrolase activity acyl-CoA hydrolase activity uc008svr.1 uc008svr.2 uc008svr.3 uc008svr.4 
ENSMUST00000095097.3 Foxe1 ENSMUST00000095097.3 forkhead box E1 (from RefSeq NM_183298.2) A2AM00 ENSMUST00000095097.1 ENSMUST00000095097.2 FOXE1_MOUSE NM_183298 Q8R2I0 Titf2 uc008sto.1 uc008sto.2 uc008sto.3 Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor (PubMed:21177256). Also implicated in thyroid gland morphogenesis (PubMed:9697704). May indirectly play a role in cell growth and migration through the regulation of WNT5A expression (By similarity). Nucleus Expressed in Rathke pouch, in thyroid, and in the epithelium of the pharyngeal wall and arches, whereas it is absent in the epithelium of the pharyngeal pouches. At 13.5 dpc, it is present in endoderm derivatives, such as tongue, palate, epiglottis, pharynx, and esophagus. Later in embryogenesis, it is detected in the choanae and whiskers. Phosphorylated. Knockout mice die before hair formation. They exhibit cleft palate and either a sublingual or completely absent thyroid gland and show neonatal hypothyroidism. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter thyroid hormone generation anatomical structure morphogenesis cell migration cell differentiation thyroid gland development hair follicle morphogenesis sequence-specific DNA binding positive regulation of transcription, DNA-templated thymus development embryonic organ morphogenesis palate development hard palate development soft palate development pharynx development cranial skeletal system development uc008sto.1 uc008sto.2 uc008sto.3 
ENSMUST00000095107.3 Ccin ENSMUST00000095107.3 calicin (from RefSeq NM_001002787.2) CALI_MOUSE ENSMUST00000095107.1 ENSMUST00000095107.2 NM_001002787 Q8CDE2 uc008srg.1 uc008srg.2 uc008srg.3 Possible morphogenetic cytoskeletal element in spermiogenic differentiation. Cytoplasm, cytoskeleton, perinuclear theca, calyx Note=Sperm head cytoskeletal structure tightly associated to the nucleus. cytoplasm cytoskeleton multicellular organism development spermatogenesis cell differentiation cytoskeletal calyx uc008srg.1 uc008srg.2 uc008srg.3 
ENSMUST00000095109.5 Hrct1 ENSMUST00000095109.5 histidine rich carboxyl terminus 1 (from RefSeq NM_027511.1) A2ANK5 ENSMUST00000095109.1 ENSMUST00000095109.2 ENSMUST00000095109.3 ENSMUST00000095109.4 HRCT1_MOUSE NM_027511 Q9D6B9 uc008sqx.1 uc008sqx.2 uc008sqx.3 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc008sqx.1 uc008sqx.2 uc008sqx.3 
ENSMUST00000095114.5 Ccl21a ENSMUST00000095114.5 C-C motif chemokine ligand 21 (serine) (from RefSeq NM_011124.4) CC21A_MOUSE ENSMUST00000095114.1 ENSMUST00000095114.2 ENSMUST00000095114.3 ENSMUST00000095114.4 NM_011124 O09002 O09006 P84444 Q3U1J2 Q91V84 Scya21 Scya21a uc008sny.1 uc008sny.2 uc008sny.3 uc008sny.4 uc008sny.5 Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to CCR7 and to CXCR3. Interacts with PDPN; relocalizes PDPN to the basolateral membrane. Interacts with GPR174 (PubMed:31875850). Secreted. Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart. Note=Mice carrying an autosomal recessive mutation designated paucity of lymph node T-cells (plt) show dramatically reduced numbers of T-cells in lymph nodes, Peyer patches, and the white pulp of the spleen. Plt seems to correspond to Scya21b. Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have 'Leu-65' (6Ckine-Leu) while Ccl21a has Ser-65 (6Ckine-Ser). Belongs to the intercrine beta (chemokine CC) family. establishment of T cell polarity immunological synapse formation positive regulation of cell-matrix adhesion dendritic cell chemotaxis monocyte chemotaxis positive regulation of dendritic cell antigen processing and presentation cytokine activity extracellular region extracellular space cell chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway chemokine activity positive regulation of glycoprotein biosynthetic process positive regulation of macrophage chemotaxis positive regulation of T cell chemotaxis neutrophil chemotaxis positive regulation of actin filament polymerization positive regulation of pseudopodium assembly T cell costimulation ruffle organization CCR7 chemokine receptor binding positive regulation of cell adhesion mediated by integrin response to prostaglandin E mesangial cell-matrix adhesion chemokine (C-C motif) ligand 21 signaling pathway chemokine receptor binding positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity positive regulation of protein kinase activity positive regulation of JNK cascade CCR chemokine receptor binding lymphocyte chemotaxis positive regulation of receptor-mediated endocytosis cell maturation lymph node development positive regulation of chemotaxis induction of positive chemotaxis release of sequestered calcium ion into cytosol positive regulation of filopodium assembly positive regulation of protein kinase B signaling cell chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of neutrophil chemotaxis activation of GTPase activity dendritic cell dendrite assembly cellular response to chemokine positive regulation of cell motility positive regulation of T cell migration positive regulation of myeloid dendritic cell chemotaxis negative regulation of dendritic cell dendrite assembly negative regulation of dendritic cell apoptotic process uc008sny.1 uc008sny.2 uc008sny.3 uc008sny.4 uc008sny.5 
ENSMUST00000095117.10 Mamdc4 ENSMUST00000095117.10 MAM domain containing 4 (from RefSeq NM_001081199.1) D3YY20 D3YY20_MOUSE ENSMUST00000095117.1 ENSMUST00000095117.2 ENSMUST00000095117.3 ENSMUST00000095117.4 ENSMUST00000095117.5 ENSMUST00000095117.6 ENSMUST00000095117.7 ENSMUST00000095117.8 ENSMUST00000095117.9 Mamdc4 NM_001081199 uc008iso.1 uc008iso.2 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc008iso.1 uc008iso.2 
ENSMUST00000095128.10 Ndufb6 ENSMUST00000095128.10 NADH:ubiquinone oxidoreductase subunit B6 (from RefSeq NM_001033305.3) ENSMUST00000095128.1 ENSMUST00000095128.2 ENSMUST00000095128.3 ENSMUST00000095128.4 ENSMUST00000095128.5 ENSMUST00000095128.6 ENSMUST00000095128.7 ENSMUST00000095128.8 ENSMUST00000095128.9 Gm137 NDUB6_MOUSE NM_001033305 Q3UIU2 uc008shk.1 uc008shk.2 uc008shk.3 This gene encodes a subunit of complex I (NADH:ubiquinone oxidoreductase) of the mitochondrial respiratory chain. This complex functions in electron transport and generation of a proton gradient across the inner mitochondrial membrane to drive ATP synthesis. Data from human cell lines suggests that the encoded subunit may be required for electron transfer activity. [provided by RefSeq, Aug 2015]. ##Evidence-Data-START## Transcript exon combination :: CK794473.1, CD774546.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side Belongs to the complex I NDUFB6 subunit family. nucleoplasm mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial electron transport, NADH to ubiquinone membrane integral component of membrane mitochondrial membrane mitochondrial respiratory chain complex I assembly mitochondrial ATP synthesis coupled electron transport oxidation-reduction process respiratory chain uc008shk.1 uc008shk.2 uc008shk.3 
ENSMUST00000095129.3 Gm136 ENSMUST00000095129.3 predicted gene 136 (from RefSeq NM_001033255.2) CF163_MOUSE ENSMUST00000095129.1 ENSMUST00000095129.2 NM_001033255 Q3V037 uc008sgk.1 uc008sgk.2 uc008sgk.3 molecular_function cellular_component biological_process uc008sgk.1 uc008sgk.2 uc008sgk.3 
ENSMUST00000095132.10 Spag6 ENSMUST00000095132.10 sperm associated antigen 6, transcript variant 3 (from RefSeq NM_001409585.1) BC061194 ENSMUST00000095132.1 ENSMUST00000095132.2 ENSMUST00000095132.3 ENSMUST00000095132.4 ENSMUST00000095132.5 ENSMUST00000095132.6 ENSMUST00000095132.7 ENSMUST00000095132.8 ENSMUST00000095132.9 NM_001409585 Q3V0U9 Q3V0U9_MOUSE Spag6 Spag6l uc008ima.1 uc008ima.2 uc008ima.3 molecular_function cellular_component biological_process uc008ima.1 uc008ima.2 uc008ima.3 
ENSMUST00000095147.9 Dhtkd1 ENSMUST00000095147.9 dehydrogenase E1 and transketolase domain containing 1 (from RefSeq NM_001081131.2) A2ATU0 DHTK1_MOUSE ENSMUST00000095147.1 ENSMUST00000095147.2 ENSMUST00000095147.3 ENSMUST00000095147.4 ENSMUST00000095147.5 ENSMUST00000095147.6 ENSMUST00000095147.7 ENSMUST00000095147.8 Kiaa1630 NM_001081131 Q0VFY3 Q69ZE3 Q8BWT3 uc008iga.1 uc008iga.2 uc008iga.3 2-oxoadipate dehydrogenase (E1a) component of the 2- oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha- ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine- residue succinyltransferase or DLST). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate. Responsible for the last step of L-lysine, L-hydroxylysine and L- tryptophan catabolism with the common product being 2-oxoadipate. Reaction=2-oxoadipate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl- [dihydrolipoyllysine-residue succinyltransferase] = CO2 + N(6)-[(R)- S(8)-glutaryldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]; Xref=Rhea:RHEA:69576, Rhea:RHEA-COMP:10483, Rhea:RHEA-COMP:17726, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57499, ChEBI:CHEBI:83099, ChEBI:CHEBI:184385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69577; Evidence=; Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Amino-acid degradation. The 2-oxoadipate dehydrogenase complex is composed of OADH (2- oxoadipate dehydrogenase; E1a), DLST (dihydrolipoamide succinyltransferase; E2) and DLD (dihydrolipoamide dehydrogenase; E3). E1a functional unit is a dimer. Mitochondrion The mitochondrial 2-oxoglutarate and 2-oxoadipate dehydrogenase complexes (OGDHC and OADHC, respectively) share their E2 (DLST) and E3 (dihydrolipoyl dehydrogenase or DLD) components, but the E1 component is specific to each complex (E1o and E1a, respectively). Belongs to the alpha-ketoglutarate dehydrogenase family. Sequence=BAD32501.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; hematopoietic progenitor cell differentiation oxoglutarate dehydrogenase (succinyl-transferring) activity mitochondrion cytosol generation of precursor metabolites and energy glycolytic process tricarboxylic acid cycle oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor thiamine pyrophosphate binding oxoglutarate dehydrogenase complex oxidation-reduction process uc008iga.1 uc008iga.2 uc008iga.3 
ENSMUST00000095157.11 Phf11d ENSMUST00000095157.11 PHD finger protein 11D, transcript variant 2 (from RefSeq NM_199015.5) A6H5X4 D14Ertd668e ENSMUST00000095157.1 ENSMUST00000095157.10 ENSMUST00000095157.2 ENSMUST00000095157.3 ENSMUST00000095157.4 ENSMUST00000095157.5 ENSMUST00000095157.6 ENSMUST00000095157.7 ENSMUST00000095157.8 ENSMUST00000095157.9 NM_199015 PHF11_MOUSE Phf11 Phf11l Q3U0T6 Q8K2R8 uc007ueg.1 uc007ueg.2 uc007ueg.3 uc007ueg.4 Positive regulator of Th1-type cytokine gene expression. Interacts with BRCA1 and RELA. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A6H5X4-1; Sequence=Displayed; Name=2; IsoId=A6H5X4-2; Sequence=VSP_038089; Name=3; IsoId=A6H5X4-3; Sequence=VSP_038090; Sequence=AAH30186.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleus nucleoplasm biological_process nuclear membrane metal ion binding uc007ueg.1 uc007ueg.2 uc007ueg.3 uc007ueg.4 
ENSMUST00000095158.11 Ccdc7a ENSMUST00000095158.11 coiled-coil domain containing 7A, transcript variant 1 (from RefSeq NM_029061.3) Biot2 CCDC7_MOUSE Ccdc7 D3YY17 ENSMUST00000095158.1 ENSMUST00000095158.10 ENSMUST00000095158.2 ENSMUST00000095158.3 ENSMUST00000095158.4 ENSMUST00000095158.5 ENSMUST00000095158.6 ENSMUST00000095158.7 ENSMUST00000095158.8 ENSMUST00000095158.9 NM_029061 Q9D541 uc009nzy.1 uc009nzy.2 uc009nzy.3 uc009nzy.4 May play a role in tumorigenesis. Exclusively expressed in the testes. Abundantly expressed in mouse cancer cell line derived from epithelial cells. molecular_function cellular_component biological_process uc009nzy.1 uc009nzy.2 uc009nzy.3 uc009nzy.4 
ENSMUST00000095171.5 Atp2c2 ENSMUST00000095171.5 ATPase, Ca++ transporting, type 2C, member 2 (from RefSeq NM_026922.1) A7L9Z8 AT2C2_MOUSE Atp2c2 ENSMUST00000095171.1 ENSMUST00000095171.2 ENSMUST00000095171.3 ENSMUST00000095171.4 Kiaa0703 NM_026922 Q5DU19 Spca2 uc009nqg.1 uc009nqg.2 uc009nqg.3 ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus (PubMed:23840669) (By similarity). Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.10; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18106; Evidence=; Reaction=ATP + H2O + Mn(2+)(in) = ADP + H(+) + Mn(2+)(out) + phosphate; Xref=Rhea:RHEA:66820, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29035, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66821; Evidence=; Interacts (via N-terminus) with ORAI1 (via N- and C-termini); this interaction regulates Ca(2+) influx at the plasma membrane. Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Expressed in hippocampal neurons (at protein level) (PubMed:15677451). Expressed in lactating mammary epithelium (at protein level) (PubMed:23840669). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. Golgi membrane nucleotide binding calcium-transporting ATPase activity protein binding ATP binding ion transport calcium ion transport cellular calcium ion homeostasis hydrogen-exporting ATPase activity, phosphorylative mechanism cytoplasmic side of plasma membrane manganese-transporting ATPase activity membrane integral component of membrane cytoplasmic vesicle metal ion binding perinuclear region of cytoplasm mammary gland epithelium development calcium ion transmembrane transport manganese ion transmembrane transport protein localization to plasma membrane positive regulation of calcium ion import hydrogen ion transmembrane transport uc009nqg.1 uc009nqg.2 uc009nqg.3 
ENSMUST00000095173.3 Syce1l ENSMUST00000095173.3 synaptonemal complex central element protein 1 like, transcript variant 1 (from RefSeq NM_001048145.1) B2RUQ1 ENSMUST00000095173.1 ENSMUST00000095173.2 Mmrp2 NM_001048145 Q497L4 Q5D524 Q5D525 Q9D5A5 SYC1L_MOUSE uc009nnq.1 uc009nnq.2 uc009nnq.3 May be involved in meiosis. Isoform 1 may be involved in meiosis during spermatogenesis while isoform 2 is probably related to a later stage of meiosis, in the development stage of secondary spermatocytes and spermatids. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=mmrp2; IsoId=Q5D525-1; Sequence=Displayed; Name=2; Synonyms=mmrp1; IsoId=Q5D525-2; Sequence=VSP_034228; Name=3; IsoId=Q5D525-3; Sequence=VSP_034227; Isoform 1 is abundantly expressed in testis and weakly in ovary, it is not found in other tissues. Isoform 2 is expressed in testis and poorly in brain, heart, lung and other examined tissues. Not detected in embryo. Isoform 1 is detected in testis at day 8 after birth while isoform 2 at day 17. Belongs to the SYCE family. Sequence=AAI00479.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; synaptonemal complex molecular_function synaptonemal complex assembly biological_process intermediate filament cytoskeleton meiotic cell cycle synaptonemal complex organization uc009nnq.1 uc009nnq.2 uc009nnq.3 
ENSMUST00000095183.2 Gm10308 ENSMUST00000095183.2 Gm10308 (from geneSymbol) AK006863 ENSMUST00000095183.1 uc289nme.1 uc289nme.2 uc289nme.1 uc289nme.2 
ENSMUST00000095186.4 Gm10309 ENSMUST00000095186.4 Gm10309 (from geneSymbol) AK076576 ENSMUST00000095186.1 ENSMUST00000095186.2 ENSMUST00000095186.3 uc289nhm.1 uc289nhm.2 uc289nhm.3 uc289nhm.1 uc289nhm.2 uc289nhm.3 
ENSMUST00000095187.4 Srbd1 ENSMUST00000095187.4 S1 RNA binding domain 1 (from RefSeq NM_030133.3) ENSMUST00000095187.1 ENSMUST00000095187.2 ENSMUST00000095187.3 F8WGW3 F8WGW3_MOUSE NM_030133 Srbd1 uc008due.1 uc008due.2 uc008due.3 nucleic acid binding nucleobase-containing compound metabolic process uc008due.1 uc008due.2 uc008due.3 
ENSMUST00000095188.7 Camkmt ENSMUST00000095188.7 calmodulin-lysine N-methyltransferase, transcript variant 1 (from RefSeq NM_028576.3) CMKMT_MOUSE Clnmt ENSMUST00000095188.1 ENSMUST00000095188.2 ENSMUST00000095188.3 ENSMUST00000095188.4 ENSMUST00000095188.5 ENSMUST00000095188.6 NM_028576 Q3U2J5 Q9D9C5 uc008dtt.1 uc008dtt.2 uc008dtt.3 Catalyzes the trimethylation of 'Lys-116' in calmodulin. Reaction=[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:21556, Rhea:RHEA-COMP:11360, Rhea:RHEA-COMP:11361, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.60; Evidence=; Monomer. Interacts with HSP90, probably as a client (By similarity). [Isoform 1]: Cytoplasm Nucleus [Isoform 2]: Golgi apparatus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U2J5-1; Sequence=Displayed; Name=2; IsoId=Q3U2J5-2; Sequence=VSP_027786, VSP_027787; Detected in most of the tissues examined, with the highest expression in the brain and muscle (at protein level). Belongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family. nucleus cytoplasm Golgi apparatus mitochondrion organization methyltransferase activity transferase activity peptidyl-lysine methylation calmodulin-lysine N-methyltransferase activity heat shock protein binding methylation macromolecular complex uc008dtt.1 uc008dtt.2 uc008dtt.3 
ENSMUST00000095208.4 Capn13 ENSMUST00000095208.4 calpain 13 (from RefSeq NM_001033444.2) B2RW21 CAN13_MOUSE ENSMUST00000095208.1 ENSMUST00000095208.2 ENSMUST00000095208.3 Gm943 NM_001033444 Q3UW68 uc033hfc.1 uc033hfc.2 uc033hfc.3 Probable non-lysosomal thiol-protease. Belongs to the peptidase C2 family. It is unlikely that this protein binds calcium as none of the 2 EF-hand domains seem to contain a canonical calcium-binding site. calcium-dependent cysteine-type endopeptidase activity calcium ion binding cytoplasm proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity uc033hfc.1 uc033hfc.2 uc033hfc.3 
ENSMUST00000095211.5 Ces1a ENSMUST00000095211.5 carboxylesterase 1A (from RefSeq NM_001013764.2) Ces1a E9PYP1 E9PYP1_MOUSE ENSMUST00000095211.1 ENSMUST00000095211.2 ENSMUST00000095211.3 ENSMUST00000095211.4 NM_001013764 uc009muj.1 uc009muj.2 uc009muj.3 Belongs to the type-B carboxylesterase/lipase family. sterol esterase activity triglyceride lipase activity extracellular space lipid catabolic process hydrolase activity carboxylic ester hydrolase activity uc009muj.1 uc009muj.2 uc009muj.3 
ENSMUST00000095214.10 Cnep1r1 ENSMUST00000095214.10 CTD nuclear envelope phosphatase 1 regulatory subunit 1 (from RefSeq NM_029074.3) A7E1Z4 ENSMUST00000095214.1 ENSMUST00000095214.2 ENSMUST00000095214.3 ENSMUST00000095214.4 ENSMUST00000095214.5 ENSMUST00000095214.6 ENSMUST00000095214.7 ENSMUST00000095214.8 ENSMUST00000095214.9 NEPR1_MOUSE NM_029074 Q3UJ81 Q8VEG8 Q9D3Q4 Tmem188 uc009mra.1 uc009mra.2 uc009mra.3 uc009mra.4 Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity). Interacts with CTDNEP1; the complex dephosphorylates LPIN1 and LPIN2. Nucleus membrane ; Multi-pass membrane protein Cytoplasm Note=Filamentous pattern in the cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UJ81-1; Sequence=Displayed; Name=2; IsoId=Q3UJ81-2; Sequence=VSP_025131; Name=3; IsoId=Q3UJ81-3; Sequence=VSP_025129, VSP_025130; Muscle specific with lower expression in other metabolic tissues. [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the CNEP1R1 family. molecular_function nucleus cytoplasm cytosol lipid metabolic process positive regulation of triglyceride biosynthetic process membrane integral component of membrane nuclear membrane protein localization to nucleus positive regulation of protein dephosphorylation Nem1-Spo7 phosphatase complex uc009mra.1 uc009mra.2 uc009mra.3 uc009mra.4 
ENSMUST00000095217.11 Obox3 ENSMUST00000095217.11 oocyte specific homeobox 3 (from RefSeq NM_145707.3) D3YXK4 ENSMUST00000095217.1 ENSMUST00000095217.10 ENSMUST00000095217.2 ENSMUST00000095217.3 ENSMUST00000095217.4 ENSMUST00000095217.5 ENSMUST00000095217.6 ENSMUST00000095217.7 ENSMUST00000095217.8 ENSMUST00000095217.9 G3UXQ8 G3UXT3 G3UZJ7 NM_145707 OBOX3_MOUSE Obox3 Ohx Q3UT54 Q8JZN9 Q8VHG6 uc009fgi.1 uc009fgi.2 uc009fgi.3 Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Together with other Obox family members, required in early two-cell stage embryos to kick-start the major ZGA wave by facilitating RNA Polymerase II 'pre-configuration', during which RNA Polymerase II relocates from the initial one-cell stage binding targets to ZGA gene promoters and distal enhancers (PubMed:37459895). Mechanistically, promotes recruitment of RNA Polymerase II from (CG-rich) non-ZGA genes to (CG-poor) ZGA genes at the two-cell stage (PubMed:37459895). Binds to regulatory DNA sequences containing a 5'-ACNCCTTTAATCCCAG-3' sequence motif (PubMed:37459895). Most maternal and zygotic Obox family proteins can compensate for one another (PubMed:37459895). Nucleus Specifically expressed in early embryos. Expressed zygotically with expression starting at mid-two-cell stage, during major zygotic genome activation (ZGA), and peaking in late two-cell stage embryos. No visible phenotype; mice are viable and fertile (PubMed:37459895). Female mice lacking maternally transcribed Obox1, Obox2, Obox5, Obox7 as well as zygotically expressed Obox3 and Obox4 are infertile: embryos arrest at two-four cell stage due to impaired zygotic genome activation (ZGA) (PubMed:37459895). Belongs to the paired homeobox family. Obox subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding uc009fgi.1 uc009fgi.2 uc009fgi.3 
ENSMUST00000095220.4 Fbxw9 ENSMUST00000095220.4 F-box and WD-40 domain protein 9 (from RefSeq NM_026791.2) ENSMUST00000095220.1 ENSMUST00000095220.2 ENSMUST00000095220.3 F8VPX2 F8VPX2_MOUSE Fbxw9 NM_026791 uc009mpd.1 uc009mpd.2 uc009mpd.3 uc009mpd.4 preribosome, large subunit precursor PeBoW complex uc009mpd.1 uc009mpd.2 uc009mpd.3 uc009mpd.4 
ENSMUST00000095224.11 Safb ENSMUST00000095224.11 scaffold attachment factor B, transcript variant 2 (from RefSeq NM_001163300.1) D3YXK2 ENSMUST00000095224.1 ENSMUST00000095224.10 ENSMUST00000095224.2 ENSMUST00000095224.3 ENSMUST00000095224.4 ENSMUST00000095224.5 ENSMUST00000095224.6 ENSMUST00000095224.7 ENSMUST00000095224.8 ENSMUST00000095224.9 NM_001163300 SAFB1_MOUSE Safb1 uc012avv.1 uc012avv.2 uc012avv.3 Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (By similarity). Thereby acts as a negative regulator of cell proliferation (By similarity). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (PubMed:19403048). Monomer and homodimer (By similarity). Forms heterodimers with SAFB2 (By similarity). Interacts with KHDRBS3 (By similarity). Interacts with CLK2 (PubMed:11118435). Interacts with POLR2A, ASF/SRSF1, SRp30c/SRFS9 and TRA2B/SFRS10 (By similarity). Interacts with SRPK1 and inhibits its activity (By similarity). Interacts with RBMX (PubMed:19403048). Interacts with FUS (By similarity). Interacts with ZBED4 (By similarity). Nucleus Sumoylated by PIAS1 with SUMO1 and SUMO2/3, desumoylated by SENP1. Sumoylation is required for transcriptional repressor activity. RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleic acid binding DNA binding chromatin binding RNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter intracellular estrogen receptor signaling pathway regulation of growth hormone metabolic process sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter regulation of mRNA processing uc012avv.1 uc012avv.2 uc012avv.3 
ENSMUST00000095228.5 Samd1 ENSMUST00000095228.5 sterile alpha motif domain containing 1 (from RefSeq NM_001081415.2) D3YXK1 ENSMUST00000095228.1 ENSMUST00000095228.2 ENSMUST00000095228.3 ENSMUST00000095228.4 NM_001081415 SAMD1_MOUSE Samd1 uc009mln.1 uc009mln.2 Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486, PubMed:34006929). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:34006929). Homopolymerize into a closed pentameric ring (By similarity). Interacts (via SAM domain) with L3MBTL3 (via SAM domain); the interaction mediates L3MBTL3 binding to chromatin (PubMed:33980486). Interacts (via WH domain) with KDM1A; the interaction modulates KDM1A function (PubMed:33980486). Nucleus Chromosome Secreted Note=In atherosclerotic lesions, it is found in the extracellular compartment and in foam cells cytoplasm. Expressed to similar levels in different organs. Expressed at higher levels in bone marrow, osteoclasts and spleen (PubMed:33980486). Expressed in vascular smooth muscle cells (PubMed:34006929). Expression is inhibited by miRNA MIR378C (PubMed:34006929). Expression is induced by PDGF (PubMed:34006929). Winged-helix (WH) domain directly recognizes and binds unmethylated CpG-containing DNA via simultaneous interactions with both the major and the minor groove of DNA. molecular_function cellular_component extracellular region cytoplasm biological_process uc009mln.1 uc009mln.2 
ENSMUST00000095263.10 Yipf3 ENSMUST00000095263.10 Yip1 domain family, member 3, transcript variant 1 (from RefSeq NM_145353.3) D17Wsu94e ENSMUST00000095263.1 ENSMUST00000095263.2 ENSMUST00000095263.3 ENSMUST00000095263.4 ENSMUST00000095263.5 ENSMUST00000095263.6 ENSMUST00000095263.7 ENSMUST00000095263.8 ENSMUST00000095263.9 Klip1 NM_145353 Q3UDR8 Q8C998 Q8K5D1 Q8VCS2 YIPF3_MOUSE uc008csd.1 uc008csd.2 uc008csd.3 Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis (By similarity). Interacts with YIPF4 and YIPF5. Cell membrane ; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein. Cytoplasm Expressed by splenocytes (at protein level). Belongs to the YIP1 family. Sequence=BAC31317.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cytoplasm Golgi apparatus plasma membrane biological_process membrane integral component of membrane transport vesicle cell differentiation intracellular membrane-bounded organelle uc008csd.1 uc008csd.2 uc008csd.3 
ENSMUST00000095266.3 Nxph4 ENSMUST00000095266.3 neurexophilin 4 (from RefSeq NM_183297.2) ENSMUST00000095266.1 ENSMUST00000095266.2 G3X9N5 G3X9N5_MOUSE NM_183297 Nxph4 uc007hjw.1 uc007hjw.2 May be signaling molecules that resemble neuropeptides. Belongs to the neurexophilin family. receptor binding cellular_component biological_process uc007hjw.1 uc007hjw.2 
ENSMUST00000095267.8 Jund ENSMUST00000095267.8 jun D proto-oncogene, transcript variant 1 (from RefSeq NM_010592.5) ENSMUST00000095267.1 ENSMUST00000095267.2 ENSMUST00000095267.3 ENSMUST00000095267.4 ENSMUST00000095267.5 ENSMUST00000095267.6 ENSMUST00000095267.7 JUND_MOUSE Jun-d Jund1 NM_010592 P15066 uc009mbe.1 uc009mbe.2 uc009mbe.3 uc009mbe.4 The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]. Transcription factor binding AP-1 sites (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing its transcriptional activity (By similarity). Heterodimer; binds DNA as a heterodimer (By similarity). Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOS proteins, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Forms heterodimers with FOSB; thereby binding to the AP-1 consensus sequence (By similarity). Interacts (via MBM motif) with MEN1; this interaction represses transcriptional activation (PubMed:9989505). Interacts with MAPK10; this interaction is inhibited in the presence of MEN1 (By similarity). Nucleus. Brain and kidney. Binds DNA via bZIP domain; DNA-binding is under control of cellular redox homeostasis (in vitro) (By similarity). To enable DNA binding, the bZIP domain must undergo a conformational rearrangement which requires the reduction of the interchain disulfide bond between FosB and JunD (in vitro) (By similarity). Phosphorylated by MAP kinases MAPK8 and MAPK10; phosphorylation is inhibited in the presence of MEN1. Belongs to the bZIP family. Jun subfamily. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding osteoblast development DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter aging circadian rhythm transcription factor binding response to radiation response to light stimulus response to mechanical stimulus response to organic substance response to organic cyclic compound ligand-dependent nuclear receptor binding enzyme binding response to lipopolysaccharide cellular response to hormone stimulus macromolecular complex protein-DNA complex response to cytokine transcription factor AP-1 complex response to drug response to peptide hormone sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter response to cAMP regulation of cell cycle cellular response to calcium ion uc009mbe.1 uc009mbe.2 uc009mbe.3 uc009mbe.4 
ENSMUST00000095273.7 Nr2c2ap ENSMUST00000095273.7 nuclear receptor 2C2-associated protein, transcript variant 2 (from RefSeq NM_001025587.2) ENSMUST00000095273.1 ENSMUST00000095273.2 ENSMUST00000095273.3 ENSMUST00000095273.4 ENSMUST00000095273.5 ENSMUST00000095273.6 NM_001025587 NR2CA_MOUSE Q3TV70 Tra16 uc033jfy.1 uc033jfy.2 uc033jfy.3 uc033jfy.4 May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes. Interacts with NR2C2/TR4. Nucleus Belongs to the NR2C2AP family. molecular_function nucleus nucleoplasm uc033jfy.1 uc033jfy.2 uc033jfy.3 uc033jfy.4 
ENSMUST00000095295.3 Trim75 ENSMUST00000095295.3 tripartite motif-containing 75 (from RefSeq NM_001033429.2) ENSMUST00000095295.1 ENSMUST00000095295.2 Gm794 NM_001033429 Q3UWZ0 TRI75_MOUSE Trim75 uc009lvd.1 uc009lvd.2 uc009lvd.3 May play a role in female meiosis. Cytoplasm, cytoskeleton, spindle Belongs to the TRIM/RBCC family. cellular_component biological_process zinc ion binding metal ion binding uc009lvd.1 uc009lvd.2 uc009lvd.3 
ENSMUST00000095313.5 Pawr ENSMUST00000095313.5 PRKC, apoptosis, WT1, regulator (from RefSeq NM_054056.2) ENSMUST00000095313.1 ENSMUST00000095313.2 ENSMUST00000095313.3 ENSMUST00000095313.4 NM_054056 PAWR_MOUSE Par4 Q0ZHI4 Q2HYJ1 Q925B0 uc007gzf.1 uc007gzf.2 uc007gzf.3 Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti- apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity). Homooligomer. Interacts (via the C-terminal region) with WT1. Interacts with THAP1. Interacts with AATF. Interacts with BACE1. Interacts with SPSB1 (via B30.2/SPRY domain); this interaction is direct and occurs in association with the Elongin BC complex (PubMed:16369487, PubMed:20561531). Interacts with SPSB2 (via B30.2/SPRY domain); this interaction occurs in association with the Elongin BC complex (PubMed:16369487, PubMed:20561531). Interacts with SPSB4 (via B30.2/SPRY domain); this interaction occurs in association with the Elongin BC complex (PubMed:16369487, PubMed:20561531). Component of a ternary complex composed of SQSTM1 and PRKCZ (By similarity). Interacts with actin (By similarity). Q925B0; O54784: Dapk3; NbExp=2; IntAct=EBI-77397, EBI-77359; Cytoplasm Nucleus Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML nuclear bodies (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q925B0-1; Sequence=Displayed; Name=2; Synonyms=P33; IsoId=Q925B0-2; Sequence=VSP_022018; The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners. The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells (By similarity). The B30.2/SPRY domain-binding motif mediates recognition by proteins containing a B30.2/SPRY domain. Preferentially phosphorylated at the Thr-156 by PKC in cancer cells. The synapses are crucial cellular sites for the cell death promoting actions of PAWR in motor neurons. Targeted inhibition of PAWR by RNAi is neuroprotective. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin actin binding protein kinase C binding protein binding nucleus cytoplasm actin filament apoptotic process protein phosphatase 1 binding positive regulation of gene expression negative regulation of gene expression negative regulation of epithelial to mesenchymal transition enzyme binding axon negative regulation of B cell proliferation positive regulation of phosphoprotein phosphatase activity interleukin-2 biosynthetic process negative regulation of T cell proliferation positive regulation of amyloid precursor protein biosynthetic process neuron projection neuronal cell body positive regulation of apoptotic process leucine zipper domain binding positive regulation of neuron apoptotic process positive regulation of action potential negative regulation of fibroblast proliferation negative regulation of T cell receptor signaling pathway detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain actin filament bundle assembly positive regulation of hindgut contraction negative regulation of calcium ion import apoptotic signaling pathway activation of cysteine-type endopeptidase activity calcium ion import across plasma membrane positive regulation of relaxation of smooth muscle positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of leukocyte tethering or rolling positive regulation of neuronal action potential positive regulation of neutrophil extravasation positive regulation of cellular senescence uc007gzf.1 uc007gzf.2 uc007gzf.3 
ENSMUST00000095323.8 Cfap96 ENSMUST00000095323.8 cilia and flagella associated protein 96, transcript variant 1 (from RefSeq NM_001033148.3) CFA96_MOUSE ENSMUST00000095323.1 ENSMUST00000095323.2 ENSMUST00000095323.3 ENSMUST00000095323.4 ENSMUST00000095323.5 ENSMUST00000095323.6 ENSMUST00000095323.7 NM_001033148 Q3U1D9 uc009lpo.1 uc009lpo.2 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Belongs to the CFAP96 family. molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton biological_process uc009lpo.1 uc009lpo.2 
ENSMUST00000095326.10 Ccdc110 ENSMUST00000095326.10 coiled-coil domain containing 110 (from RefSeq NM_001033246.3) CC110_MOUSE ENSMUST00000095326.1 ENSMUST00000095326.2 ENSMUST00000095326.3 ENSMUST00000095326.4 ENSMUST00000095326.5 ENSMUST00000095326.6 ENSMUST00000095326.7 ENSMUST00000095326.8 ENSMUST00000095326.9 Gm172 NM_001033246 Q3TTQ8 Q3V125 uc009lpm.1 uc009lpm.2 uc009lpm.3 Nucleus molecular_function nucleus biological_process uc009lpm.1 uc009lpm.2 uc009lpm.3 
ENSMUST00000095328.6 Cyp4v3 ENSMUST00000095328.6 cytochrome P450, family 4, subfamily v, polypeptide 3 (from RefSeq NM_133969.3) CP4V2_MOUSE Cyp4v2 ENSMUST00000095328.1 ENSMUST00000095328.2 ENSMUST00000095328.3 ENSMUST00000095328.4 ENSMUST00000095328.5 NM_133969 Q9DBW0 uc009lou.1 uc009lou.2 uc009lou.3 A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs. Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38947, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:36204, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38948; Evidence=; Reaction=O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:40203, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30807, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77033; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40204; Evidence=; Reaction=hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:40199, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:55329, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.80; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40200; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)- eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39791, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76639; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39792; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)- docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:40155, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77015, ChEBI:CHEBI:77016; EC=1.14.14.79; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40156; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Inhibited by N-hydroxy-N'-(4-n-butyl-2- methylphenyl formamidine)(HET0016) with an IC(50) of 38 nM. Lipid metabolism; fatty acid metabolism. Endoplasmic reticulum membrane ; Single-pass membrane protein Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cellular_component endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid omega-oxidation membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc009lou.1 uc009lou.2 uc009lou.3 
ENSMUST00000095342.11 H2-Ob ENSMUST00000095342.11 histocompatibility 2, O region beta locus (from RefSeq NM_010389.3) ENSMUST00000095342.1 ENSMUST00000095342.10 ENSMUST00000095342.2 ENSMUST00000095342.3 ENSMUST00000095342.4 ENSMUST00000095342.5 ENSMUST00000095342.6 ENSMUST00000095342.7 ENSMUST00000095342.8 ENSMUST00000095342.9 H2-IAbeta2 H2-Ob NM_010389 O35424 O35424_MOUSE uc008cca.1 uc008cca.2 uc008cca.3 uc008cca.4 Membrane ; Single- pass type I membrane protein Belongs to the MHC class II family. adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of antigen processing and presentation of peptide antigen via MHC class II lysosome immune response membrane integral component of membrane antigen processing and presentation MHC class II protein complex binding MHC class II protein complex uc008cca.1 uc008cca.2 uc008cca.3 uc008cca.4 
ENSMUST00000095345.5 Mboat4 ENSMUST00000095345.5 membrane bound O-acyltransferase domain containing 4, transcript variant 2 (from RefSeq NM_001411738.1) B1Q004 B2RWL6 ENSMUST00000095345.1 ENSMUST00000095345.2 ENSMUST00000095345.3 ENSMUST00000095345.4 Gm171 Goat MBOA4_MOUSE Mboat4 NM_001411738 P0C7A3 uc012gch.1 uc012gch.2 uc012gch.3 Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (PubMed:18267071, PubMed:24045953, PubMed:28134508, PubMed:18669668, PubMed:18443287, PubMed:19501572). In vitro uses also acyl-CoA donors of different lengths from short-chain (C2) to long- chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient (PubMed:19501572). [44,4 kDa fragment]: Inactive octanoyltransferase activity. Reaction=L-seryl-[protein] + octanoyl-CoA = CoA + O-octanoyl-L-seryl- [protein]; Xref=Rhea:RHEA:59964, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:15484, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:143548; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59965; Evidence= Reaction=hexanoyl-CoA + L-seryl-[protein] = CoA + O-hexanoyl-L-seryl- [protein]; Xref=Rhea:RHEA:68284, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:17463, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:62620, ChEBI:CHEBI:177289; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68285; Evidence=; Reaction=decanoyl-CoA + L-seryl-[protein] = CoA + O-decanoyl-L-seryl- [protein]; Xref=Rhea:RHEA:59972, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:15486, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430, ChEBI:CHEBI:143549; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59973; Evidence=; Reaction=acetyl-CoA + L-seryl-[protein] = CoA + O-acetyl-L-seryl- [protein]; Xref=Rhea:RHEA:59392, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:15352, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:141128; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59393; Evidence=; Reaction=butanoyl-CoA + L-seryl-[protein] = CoA + O-butanoyl-L-seryl- [protein]; Xref=Rhea:RHEA:68276, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:17461, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371, ChEBI:CHEBI:177287; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68277; Evidence=; Reaction=L-seryl-[protein] + pentanoyl-CoA = CoA + O-pentanoyl-L-seryl- [protein]; Xref=Rhea:RHEA:68280, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:17462, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:57389, ChEBI:CHEBI:177288; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68281; Evidence=; Reaction=heptanoyl-CoA + L-seryl-[protein] = CoA + O-heptanoyl-L-seryl- [protein]; Xref=Rhea:RHEA:68288, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:17464, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:78811, ChEBI:CHEBI:177290; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68289; Evidence=; Reaction=L-seryl-[protein] + nonanoyl-CoA = CoA + O-nonanoyl-L-seryl- [protein]; Xref=Rhea:RHEA:68292, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:17465, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:76291, ChEBI:CHEBI:177291; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68293; Evidence=; Reaction=dodecanoyl-CoA + L-seryl-[protein] = CoA + O-dodecanoyl-L- seryl-[protein]; Xref=Rhea:RHEA:68296, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:17466, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:177292; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68297; Evidence=; Reaction=L-seryl-[protein] + tetradecanoyl-CoA = CoA + O-tetradecanoyl- L-seryl-[protein]; Xref=Rhea:RHEA:68300, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:17467, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:177293; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68301; Evidence=; Reaction=a fatty acyl-CoA + L-seryl-[protein] = CoA + O-fatty acyl-L- seryl-[protein]; Xref=Rhea:RHEA:68272, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:17460, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:77636, ChEBI:CHEBI:177286; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68273; Evidence=; Inhibited by 1-[2-cyano-3,12-dioxooleana- 1,9(11)- dien-28-oyl]ethylamide (CDDO-EA) with an IC(50) of 60 uM (PubMed:28134508). Inhibited by Fe3+ and Cu2+ and the O-acyltransferase activity is completely blocked over 5 mM Fe3+ and 0.5 mM Cu2+ (PubMed:19501572). Kinetic parameters: KM=294 uM for n-hexanoyl-CoA ; KM=13.6 uM for n-octanoyl-CoA ; KM=0.6 uM for octanoyl CoA ; KM=6 uM for proghrelin ; pH dependence: Optimum pH is 7.0-7.5. ; Temperature dependence: Optimum temperature is 37-50 degrees Celsius. ; Monomer. Endoplasmic reticulum membrane ; Multi-pass membrane protein Highly expressed in stomach and pancreas (PubMed:18267071). Lower expression in small intestine and colon (PubMed:18267071). Very low expression in testis (PubMed:18267071). Not glycosylated. Mice display a complete lack of octanoylated ghrelin in blood. Belongs to the membrane-bound acyltransferase family. Sequence=AAI47845.1; Type=Erroneous initiation; Evidence=; Sequence=AAI47850.1; Type=Erroneous initiation; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane serine O-acyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-serine octanoylation integral component of endoplasmic reticulum membrane uc012gch.1 uc012gch.2 uc012gch.3 
ENSMUST00000095349.6 Ubxn8 ENSMUST00000095349.6 UBX domain protein 8 (from RefSeq NM_178648.2) ENSMUST00000095349.1 ENSMUST00000095349.2 ENSMUST00000095349.3 ENSMUST00000095349.4 ENSMUST00000095349.5 NM_178648 Q3TTF2 Q3TTF2_MOUSE Ubxd6 Ubxn8 uc009lke.1 uc009lke.2 uc009lke.3 nucleoplasm nucleolus endoplasmic reticulum membrane integral component of membrane ER-associated ubiquitin-dependent protein catabolic process uc009lke.1 uc009lke.2 uc009lke.3 
ENSMUST00000095360.11 Igf1 ENSMUST00000095360.11 insulin-like growth factor 1, transcript variant 4 (from RefSeq NM_001111275.2) ENSMUST00000095360.1 ENSMUST00000095360.10 ENSMUST00000095360.2 ENSMUST00000095360.3 ENSMUST00000095360.4 ENSMUST00000095360.5 ENSMUST00000095360.6 ENSMUST00000095360.7 ENSMUST00000095360.8 ENSMUST00000095360.9 Igf1 NM_001111275 Q4VJC0 Q4VJC0_MOUSE uc007gqw.1 uc007gqw.2 uc007gqw.3 uc007gqw.4 uc007gqw.5 This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. This gene is predominantly expressed in the liver and the encoded protein undergoes proteolytic processing to generate a disulfide-linked mature polypeptide. Transgenic disruption of this gene in mice results in reduced postnatal survival and severe growth retardation. Mice lacking the encoded protein exhibit generalized organ hypoplasia including underdevelopment of the central nervous system and developmental defects in bone, muscle and reproductive systems. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]. Secreted Belongs to the insulin family. hormone activity extracellular region extracellular space signal transduction growth factor activity uc007gqw.1 uc007gqw.2 uc007gqw.3 uc007gqw.4 uc007gqw.5 
ENSMUST00000095364.3 Gm54637 ENSMUST00000095364.3 Gm54637 (from geneSymbol) A0A075B5I0 A0A075B5I0_MOUSE ENSMUST00000095364.1 ENSMUST00000095364.2 Gm54637 Ighv1-13 uc288jxw.1 uc288jxw.2 uc288jxw.1 uc288jxw.2 
ENSMUST00000095375.7 Tex24 ENSMUST00000095375.7 Tex24 (from geneSymbol) AY552600 ENSMUST00000095375.1 ENSMUST00000095375.2 ENSMUST00000095375.3 ENSMUST00000095375.4 ENSMUST00000095375.5 ENSMUST00000095375.6 uc009lir.1 uc009lir.2 uc009lir.3 uc009lir.4 uc009lir.1 uc009lir.2 uc009lir.3 uc009lir.4 
ENSMUST00000095383.6 Tmem263 ENSMUST00000095383.6 transmembrane protein 263 (from RefSeq NM_001013028.2) ENSMUST00000095383.1 ENSMUST00000095383.2 ENSMUST00000095383.3 ENSMUST00000095383.4 ENSMUST00000095383.5 NM_001013028 Q9DAM7 TM263_MOUSE uc007glb.1 uc007glb.2 uc007glb.3 uc007glb.4 May play a role in bone development. Membrane ; Multi-pass membrane protein Belongs to the TMEM263 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007glb.1 uc007glb.2 uc007glb.3 uc007glb.4 
ENSMUST00000095391.3 Tas2r140 ENSMUST00000095391.3 taste receptor, type 2, member 140 (from RefSeq NM_021562.1) A6H6Q9 ENSMUST00000095391.1 ENSMUST00000095391.2 NM_021562 Q7TQA4 Q9JKA0 Q9JKA2 T2r64 TR140_MOUSE Tas2r13 Tas2r137 Tas2r40 Tas2r8 uc009ejy.1 uc009ejy.2 uc009ejy.3 Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Membrane ; Multi-pass membrane protein Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway taste receptor activity membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009ejy.1 uc009ejy.2 uc009ejy.3 
ENSMUST00000095394.4 Tas2r115 ENSMUST00000095394.4 taste receptor, type 2, member 115 (from RefSeq NM_207020.1) ENSMUST00000095394.1 ENSMUST00000095394.2 ENSMUST00000095394.3 NM_207020 Q7M719 Q7M719_MOUSE Tas2r115 uc009ejl.1 uc009ejl.2 uc009ejl.3 Membrane ulti-pass membrane protein Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009ejl.1 uc009ejl.2 uc009ejl.3 
ENSMUST00000095395.2 Tas2r121 ENSMUST00000095395.2 taste receptor, type 2, member 121 (from RefSeq NM_207024.1) ENSMUST00000095395.1 NM_207024 Q7M720 T2R13_MOUSE Tas2r121 Tas2r13 uc009ejj.1 uc009ejj.2 Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Cell membrane; Multi-pass membrane protein. Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli. Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane positive regulation of cytokinesis bitter taste receptor activity response to stimulus sensory perception of taste uc009ejj.1 uc009ejj.2 
ENSMUST00000095409.3 Klrh1 ENSMUST00000095409.3 killer cell lectin-like receptor subfamily H, member 1, transcript variant 1 (from RefSeq NM_001014997.2) ENSMUST00000095409.1 ENSMUST00000095409.2 Gm156 KLRH1 Klrh1 NM_001014997 Q58A37 Q58A37_MOUSE uc009egs.1 uc009egs.2 biological_process membrane integral component of membrane carbohydrate binding uc009egs.1 uc009egs.2 
ENSMUST00000095410.8 Wdr20 ENSMUST00000095410.8 WD repeat domain 20, transcript variant 1 (from RefSeq NM_027149.4) ENSMUST00000095410.1 ENSMUST00000095410.2 ENSMUST00000095410.3 ENSMUST00000095410.4 ENSMUST00000095410.5 ENSMUST00000095410.6 ENSMUST00000095410.7 NM_027149 Q3UWE6 Q3UWE6_MOUSE Wdr20 Wdr20a uc007pbt.1 uc007pbt.2 uc007pbt.3 molecular_function cellular_component biological_process uc007pbt.1 uc007pbt.2 uc007pbt.3 
ENSMUST00000095424.6 Defa36 ENSMUST00000095424.6 defensin, alpha, 36 (from RefSeq NM_001270613.1) Defa36 Defa37 ENSMUST00000095424.1 ENSMUST00000095424.2 ENSMUST00000095424.3 ENSMUST00000095424.4 ENSMUST00000095424.5 K9J724 K9J724_MOUSE NM_001270613 uc029wrr.1 uc029wrr.2 uc029wrr.3 uc029wrr.4 Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc029wrr.1 uc029wrr.2 uc029wrr.3 uc029wrr.4 
ENSMUST00000095425.2 Defa25 ENSMUST00000095425.2 defensin, alpha, 25 (from RefSeq NM_007849.2) DFA25_MOUSE Defcr25 ENSMUST00000095425.1 NM_007849 Q5G864 uc012gaq.1 uc012gaq.2 May have microbicidal activities. Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc012gaq.1 uc012gaq.2 
ENSMUST00000095427.12 Mtch1 ENSMUST00000095427.12 mitochondrial carrier 1, transcript variant 1 (from RefSeq NM_019880.4) ENSMUST00000095427.1 ENSMUST00000095427.10 ENSMUST00000095427.11 ENSMUST00000095427.2 ENSMUST00000095427.3 ENSMUST00000095427.4 ENSMUST00000095427.5 ENSMUST00000095427.6 ENSMUST00000095427.7 ENSMUST00000095427.8 ENSMUST00000095427.9 MTCH1_MOUSE NM_019880 Q3U4W7 Q791T5 Q791V6 Q8R0T0 Q8R1T8 Q8R2T2 Q9QZA5 Q9QZP4 uc008bst.1 uc008bst.2 uc008bst.3 Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (By similarity). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins. Does not mediate insertion of beta-barrel transmembrane proteins (By similarity). May play a role in apoptosis (By similarity). Interacts with PSEN1. Mitochondrion outer membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q791T5-1; Sequence=Displayed; Name=2; IsoId=Q791T5-2; Sequence=VSP_017883; Belongs to the mitochondrial carrier (TC 2.A.29) family. Sequence=AAH23135.1; Type=Erroneous initiation; Evidence=; Sequence=AAH26436.1; Type=Erroneous initiation; Evidence=; Sequence=AAH27274.1; Type=Erroneous initiation; Evidence=; Sequence=BAE32313.1; Type=Erroneous initiation; Evidence=; mitochondrion mitochondrial inner membrane apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process membrane integral component of membrane positive regulation of apoptotic process uc008bst.1 uc008bst.2 uc008bst.3 
ENSMUST00000095430.4 Gm6040 ENSMUST00000095430.4 predicted gene 6040 (from RefSeq NM_001025353.2) Defb51 Defb52 EG574083 ENSMUST00000095430.1 ENSMUST00000095430.2 ENSMUST00000095430.3 Gm6040 NM_001025353 Q4QY32 Q4QY32_MOUSE uc009lbh.1 uc009lbh.2 uc009lbh.3 molecular_function cellular_component biological_process uc009lbh.1 uc009lbh.2 uc009lbh.3 
ENSMUST00000095436.2 Defb46 ENSMUST00000095436.2 defensin beta 46 (from RefSeq NM_001025351.1) Defb46 Defb50 Defb53 EG574081 ENSMUST00000095436.1 NM_001025351 Q4QY34 Q4QY34_MOUSE uc009lam.1 uc009lam.2 extracellular space chemotaxis CCR6 chemokine receptor binding chemoattractant activity defense response to bacterium positive chemotaxis cell chemotaxis uc009lam.1 uc009lam.2 
ENSMUST00000095438.10 Xkr5 ENSMUST00000095438.10 X-linked Kx blood group related 5, transcript variant 3 (from RefSeq NM_001286469.1) ENSMUST00000095438.1 ENSMUST00000095438.2 ENSMUST00000095438.3 ENSMUST00000095438.4 ENSMUST00000095438.5 ENSMUST00000095438.6 ENSMUST00000095438.7 ENSMUST00000095438.8 ENSMUST00000095438.9 NM_001286469 Q5GH66 XKR5_MOUSE Xkr5 Xrg5 uc009kzx.1 uc009kzx.2 uc009kzx.3 uc009kzx.4 Cell membrane ; Multi-pass membrane protein Belongs to the XK family. molecular_function plasma membrane membrane integral component of membrane engulfment of apoptotic cell phosphatidylserine exposure on apoptotic cell surface apoptotic process involved in development uc009kzx.1 uc009kzx.2 uc009kzx.3 uc009kzx.4 
ENSMUST00000095439.11 Syne3 ENSMUST00000095439.11 spectrin repeat containing, nuclear envelope family member 3, transcript variant 3 (from RefSeq NM_001403458.1) ENSMUST00000095439.1 ENSMUST00000095439.10 ENSMUST00000095439.2 ENSMUST00000095439.3 ENSMUST00000095439.4 ENSMUST00000095439.5 ENSMUST00000095439.6 ENSMUST00000095439.7 ENSMUST00000095439.8 ENSMUST00000095439.9 NM_001403458 Q4FZC9 Q8BMM1 Q8C117 SYNE3_MOUSE uc007oxr.1 uc007oxr.2 uc007oxr.3 uc007oxr.4 As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells (By similarity). Core component of LINC complexes which are composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain- containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents can give rise to specific assemblies. Interacts with SUN1 and SUN2; probably forming respective LINC complexes. Interacts with PLEC (via actin-binding domain). Interacts with DST. Interacts with SYNE1. Interacts (via KASH domain) with TOR1A (ATP-bound); the interaction is required for SYNE3 nuclear envelope localization. Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Rough endoplasmic reticulum. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q4FZC9-1; Sequence=Displayed; Name=2; IsoId=Q4FZC9-2; Sequence=VSP_023979, VSP_023980; Ubiquitous. The KASH domain is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains. The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces. Belongs to the nesprin family. Sequence=BAC26351.1; Type=Frameshift; Evidence=; protein binding nucleus nuclear envelope nuclear outer membrane cytoplasm endoplasmic reticulum rough endoplasmic reticulum cytoskeleton organization nuclear migration cytoskeletal protein binding regulation of cell shape membrane integral component of membrane nuclear membrane LINC complex actin filament binding nucleus localization establishment of protein localization to membrane cytoskeletal anchoring at nuclear membrane uc007oxr.1 uc007oxr.2 uc007oxr.3 uc007oxr.4 
ENSMUST00000095440.9 Akap3 ENSMUST00000095440.9 A kinase anchor protein 3 (from RefSeq NM_009650.2) AKAP3_MOUSE Akap110 ENSMUST00000095440.1 ENSMUST00000095440.2 ENSMUST00000095440.3 ENSMUST00000095440.4 ENSMUST00000095440.5 ENSMUST00000095440.6 ENSMUST00000095440.7 ENSMUST00000095440.8 NM_009650 O88987 Q497M9 uc009dvf.1 uc009dvf.2 uc009dvf.3 Has a role in the maintenance of acrosome structure. May function as a regulator of both spermatozoa motility and head- associated functions such as capacitation and the acrosome reaction. Interacts with ROPN1 and ROPN1L. Interacts with QRICH2 (By similarity). O88987; Q99MP8: Brap; NbExp=3; IntAct=EBI-9033539, EBI-10818333; Cytoplasmic vesicle, secretory vesicle, acrosome Note=Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment. RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. Phosphorylated on tyrosine. Belongs to the AKAP110 family. acrosomal vesicle blastocyst hatching protein binding cytoplasm transmembrane receptor protein serine/threonine kinase signaling pathway protein localization cytoplasmic vesicle motile cilium sperm fibrous sheath protein kinase A binding sperm principal piece uc009dvf.1 uc009dvf.2 uc009dvf.3 
ENSMUST00000095446.10 Adamtsl5 ENSMUST00000095446.10 ADAMTS-like 5, transcript variant 1 (from RefSeq NM_001285435.2) Adamtsl5 D3Z689 D3Z689_MOUSE ENSMUST00000095446.1 ENSMUST00000095446.2 ENSMUST00000095446.3 ENSMUST00000095446.4 ENSMUST00000095446.5 ENSMUST00000095446.6 ENSMUST00000095446.7 ENSMUST00000095446.8 ENSMUST00000095446.9 NM_001285435 uc033frc.1 uc033frc.2 uc033frc.3 extracellular region biological_process heparin binding extracellular matrix microfibril uc033frc.1 uc033frc.2 uc033frc.3 
ENSMUST00000095458.6 Smim15 ENSMUST00000095458.6 small integral membrane protein 15 (from RefSeq NM_001048250.2) ENSMUST00000095458.1 ENSMUST00000095458.2 ENSMUST00000095458.3 ENSMUST00000095458.4 ENSMUST00000095458.5 NM_001048250 Q3UTD9 SIM15_MOUSE uc007rut.1 uc007rut.2 uc007rut.3 Membrane ; Single-pass membrane protein Belongs to the SMIM15 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007rut.1 uc007rut.2 uc007rut.3 
ENSMUST00000095464.3 Cimap1d ENSMUST00000095464.3 CIMAP1 family member D (from RefSeq NM_001033473.2) B2RVV0 CMA1D_MOUSE ENSMUST00000095464.1 ENSMUST00000095464.2 Gm1157 NM_001033473 Odf3l2 Q3TZ65 uc007fze.1 uc007fze.2 Belongs to the CIMAP family. molecular_function cytoplasmic microtubule biological_process uc007fze.1 uc007fze.2 
ENSMUST00000095467.4 Mucl3 ENSMUST00000095467.4 mucin like 3 (from RefSeq NM_001033366.3) Dpcr1 ENSMUST00000095467.1 ENSMUST00000095467.2 ENSMUST00000095467.3 Gm630 MUCL3_MOUSE Mucl3 NM_001033366 Q3TNW5 uc012aro.1 uc012aro.2 uc012aro.3 May modulate NF-kappaB signaling and play a role in cell growth. Cell membrane ; Single-pass type I membrane protein Cytoplasm molecular_function cellular_component cytoplasm plasma membrane membrane integral component of membrane uc012aro.1 uc012aro.2 uc012aro.3 
ENSMUST00000095476.6 Lig4 ENSMUST00000095476.6 ligase IV, DNA, ATP-dependent, transcript variant 1 (from RefSeq NM_176953.4) DNLI4_MOUSE ENSMUST00000095476.1 ENSMUST00000095476.2 ENSMUST00000095476.3 ENSMUST00000095476.4 ENSMUST00000095476.5 G3UWC4 Lig4 NM_176953 Q3UG76 Q8BTF7 uc009kul.1 uc009kul.2 uc009kul.3 DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps. Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. LIG4 regulates nuclear localization of XRCC4. Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.; EC=6.5.1.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with XRCC4; the LIG4-XRCC4 subcomplex has a 1:2 stoichiometry and XRCC4 is required for LIG4 stability. Component of the core long-range non-homologous end joining (NHEJ) complex (also named DNA-PK complex) composed of PRKDC, LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF. Additional component of the NHEJ complex includes PAXX. Following autophosphorylation, PRKDC dissociates from DNA, leading to formation of the short-range NHEJ complex, composed of LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF. Interacts with DCLRE1C; the interaction is direct. Interacts with APLF. Nucleus Embryonic lethality associated with extensive apoptotic cell death in the embryonic central nervous system. Belongs to the ATP-dependent DNA ligase family. single strand break repair nucleotide binding condensed chromosome in utero embryonic development pro-B cell differentiation DNA binding DNA ligase activity DNA ligase (ATP) activity protein binding ATP binding nucleus nucleoplasm DNA-dependent protein kinase-DNA ligase 4 complex DNA replication DNA ligation DNA repair nucleotide-excision repair, DNA gap filling double-strand break repair double-strand break repair via nonhomologous end joining DNA recombination cellular response to DNA damage stimulus cell cycle central nervous system development protein C-terminus binding cell proliferation response to X-ray response to ionizing radiation response to gamma radiation ligase activity DNA ligase IV complex T cell differentiation in thymus V(D)J recombination immunoglobulin V(D)J recombination T cell receptor V(D)J recombination somatic stem cell population maintenance cytoplasmic ribonucleoprotein granule negative regulation of neuron apoptotic process isotype switching metal ion binding positive regulation of fibroblast proliferation positive regulation of neurogenesis DNA ligation involved in DNA recombination DNA ligation involved in DNA repair chromosome organization cell division neuron apoptotic process nonhomologous end joining complex cellular response to lithium ion cellular response to ionizing radiation DNA biosynthetic process double-strand break repair via classical nonhomologous end joining positive regulation of chromosome organization uc009kul.1 uc009kul.2 uc009kul.3 
ENSMUST00000095491.5 Krtap10-27 ENSMUST00000095491.5 predicted gene 9507 (from RefSeq NM_001370816.1) D3Z5T3 D3Z5T3_MOUSE ENSMUST00000095491.1 ENSMUST00000095491.2 ENSMUST00000095491.3 ENSMUST00000095491.4 Gm9507 NM_001370816 uc287smq.1 uc287smq.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc287smq.1 uc287smq.2 
ENSMUST00000095500.5 Ccdc78 ENSMUST00000095500.5 coiled-coil domain containing 78 (from RefSeq NM_001165929.1) CCD78_MOUSE D3Z5T1 ENSMUST00000095500.1 ENSMUST00000095500.2 ENSMUST00000095500.3 ENSMUST00000095500.4 NM_001165929 uc012ank.1 uc012ank.2 Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, perinuclear region Cell membrane, sarcolemma Sarcoplasmic reticulum Note=Localizes to centrioles and deuterosome. Found primarily in the perinuclear region as well as along the sarcolemmal membrane and in reticular pattern within the sarcoplasm (By similarity). Belongs to the CCDC78 family. skeletal muscle contraction molecular_function cytoplasm centriole cytoskeleton plasma membrane membrane sarcoplasmic reticulum cell projection organization sarcolemma perinuclear region of cytoplasm de novo centriole assembly involved in multi-ciliated epithelial cell differentiation deuterosome uc012ank.1 uc012ank.2 
ENSMUST00000095509.6 Oog1 ENSMUST00000095509.6 oogenesin 1 (from RefSeq NM_178657.5) E9Q5G7 ENSMUST00000095509.1 ENSMUST00000095509.2 ENSMUST00000095509.3 ENSMUST00000095509.4 ENSMUST00000095509.5 NM_178657 OOG1_MOUSE Oog Oog1 Q810D9 uc007oji.1 uc007oji.2 uc007oji.3 uc007oji.4 uc007oji.5 uc007oji.6 May down-regulate the expression of spermatogenesis- associated genes in female germ cells allowing their normal differentiation into oocytes (PubMed:29731491). May act as a Ras- mediated signaling protein in early embryogenesis. Interacts with RALGDS (via Ras-associating domain) (PubMed:16580637). Interacts with HRAS (in GTP-bound form) (PubMed:16580637). E9Q5G7; Q03385: Ralgds; NbExp=5; IntAct=EBI-923698, EBI-923705; Nucleus toplasm te=In early one-cell embryos, exists only in the cytoplasm and gradually moves to the nucleus at the middle one-cell stage. At the late one-cell and early two-cell stages, higher levels in nucleus than cytoplasm. After the middle two-cell stage, mainly cytoplasmic and completely cytoplasmic after the four-cell stage. Expressed in the ovary, ovulated oocytes and preimplantation embryos (at protein level). Not detected in testis, liver, kidney, spleen, heart, lung and brain. Expressed predominantly in oocytes and one- to four-cell-stage embryos with weak expression in morula/blastocyst-stage embryos (at protein level). Expression increases from oocyte to the one-cell stage and then decreases toward the four-cell stage (at protein level). Highly expressed in oocytes of primary, secondary and antral follicles with low levels in oocytes of primordial follicles (at protein level). Expression of spermatogenesis-associated genes including Klhl10, Tekt2, Tdrd6 and Tnp2 are significantly up-regulated in the ovaries. Belongs to the PRAME family. Sequence=BAB91151.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding nucleus cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc007oji.1 uc007oji.2 uc007oji.3 uc007oji.4 uc007oji.5 uc007oji.6 
ENSMUST00000095517.12 Cog8 ENSMUST00000095517.12 component of oligomeric golgi complex 8 (from RefSeq NM_139229.4) COG8_MOUSE ENSMUST00000095517.1 ENSMUST00000095517.10 ENSMUST00000095517.11 ENSMUST00000095517.2 ENSMUST00000095517.3 ENSMUST00000095517.4 ENSMUST00000095517.5 ENSMUST00000095517.6 ENSMUST00000095517.7 ENSMUST00000095517.8 ENSMUST00000095517.9 MNCb-5704 NM_139229 Q8BFW5 Q9JJA2 uc012gjz.1 uc012gjz.2 uc012gjz.3 Required for normal Golgi function. Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Golgi apparatus membrane ; Peripheral membrane protein Belongs to the COG8 family. Golgi membrane molecular_function Golgi apparatus intra-Golgi vesicle-mediated transport protein transport membrane Golgi transport complex uc012gjz.1 uc012gjz.2 uc012gjz.3 
ENSMUST00000095541.11 Susd2 ENSMUST00000095541.11 sushi domain containing 2, transcript variant 1 (from RefSeq NM_027890.5) ENSMUST00000095541.1 ENSMUST00000095541.10 ENSMUST00000095541.2 ENSMUST00000095541.3 ENSMUST00000095541.4 ENSMUST00000095541.5 ENSMUST00000095541.6 ENSMUST00000095541.7 ENSMUST00000095541.8 ENSMUST00000095541.9 NM_027890 Q8BY19 Q8BYN0 Q8BYZ3 Q8BYZ9 Q8BZQ4 Q8C179 Q9DBX3 SUSD2_MOUSE uc007fqt.1 uc007fqt.2 uc007fqt.3 uc007fqt.4 May be a cytokine receptor for GPR15LG. May be a tumor suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity). May play a role in breast tumorigenesis (PubMed:23131994). Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DBX3-1; Sequence=Displayed; Name=2; IsoId=Q9DBX3-2; Sequence=VSP_020426; Name=3; IsoId=Q9DBX3-3; Sequence=VSP_020425; Sequence=BAC29714.1; Type=Frameshift; Evidence=; molecular_function scavenger receptor activity plasma membrane endocytosis immune response membrane integral component of membrane polysaccharide binding negative regulation of cell division negative regulation of cell cycle G1/S phase transition uc007fqt.1 uc007fqt.2 uc007fqt.3 uc007fqt.4 
ENSMUST00000095544.6 Npw ENSMUST00000095544.6 neuropeptide W (from RefSeq NM_001099664.2) ENSMUST00000095544.1 ENSMUST00000095544.2 ENSMUST00000095544.3 ENSMUST00000095544.4 ENSMUST00000095544.5 F7B5D6 F7B5D6_MOUSE NM_001099664 Npw uc008axm.1 uc008axm.2 uc008axm.3 uc008axm.4 Orthologs of this gene express a preproprotein that is processed into a neuropeptide ligand for two G-protein coupled receptors in the central nervous system. The neuropeptide is thought to directly or indirectly regulate feeding, weight regulation, and pain response. The preproprotein is translated using a non-AUG initiation codon. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BY708553.1, AK131881.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 12719537 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Secreted Belongs to the neuropeptide B/W family. G-protein coupled receptor binding cellular_component G-protein coupled receptor signaling pathway feeding behavior uc008axm.1 uc008axm.2 uc008axm.3 uc008axm.4 
ENSMUST00000095550.4 Syndig1l ENSMUST00000095550.4 synapse differentiation inducing 1 like (from RefSeq NM_001033334.2) ENSMUST00000095550.1 ENSMUST00000095550.2 ENSMUST00000095550.3 Gm261 NM_001033334 Q3USQ7 SYN1L_MOUSE SynDIG2 Tmem90a uc007ofr.1 uc007ofr.2 uc007ofr.3 Membrane ; Multi-pass membrane protein Golgi apparatus, cis-Golgi network Expression is restricted to the caudate-putamen. Down-regulated in R6/2 transgenic mice, a model for Huntington disease. Belongs to the CD225/Dispanin family. molecular_function Golgi apparatus biological_process membrane integral component of membrane uc007ofr.1 uc007ofr.2 uc007ofr.3 
ENSMUST00000095576.5 Scel ENSMUST00000095576.5 sciellin (from RefSeq NM_022886.2) ENSMUST00000095576.1 ENSMUST00000095576.2 ENSMUST00000095576.3 ENSMUST00000095576.4 NM_022886 Q9CTT9 Q9EQG3 SCEL_MOUSE uc007uwr.1 uc007uwr.2 uc007uwr.3 May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope (By similarity). Cytoplasm. Membrane. Note=May become cross-linked to membrane proteins by transglutaminase. Expressed in the upper layers of stratified epithelia, including, ependyma and choroid plexus of the brain ventricles. Strong expression was seen in 17-17.5 day-old embryos. Expression was also detected in the amnion of 17.5 day-old embryo. cytoplasm epidermis development response to mechanical stimulus embryo development ending in birth or egg hatching membrane keratinocyte differentiation metal ion binding perinuclear region of cytoplasm positive regulation of canonical Wnt signaling pathway uc007uwr.1 uc007uwr.2 uc007uwr.3 
ENSMUST00000095579.11 Thoc6 ENSMUST00000095579.11 THO complex 6, transcript variant 2 (from RefSeq NM_001357380.1) ENSMUST00000095579.1 ENSMUST00000095579.10 ENSMUST00000095579.2 ENSMUST00000095579.3 ENSMUST00000095579.4 ENSMUST00000095579.5 ENSMUST00000095579.6 ENSMUST00000095579.7 ENSMUST00000095579.8 ENSMUST00000095579.9 NM_001357380 Q5U4D9 THOC6_MOUSE Wdr58 uc008ast.1 uc008ast.2 uc008ast.3 Acts as a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.Plays a role in apoptosis negative control involved in brain development (By similarity). Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Nucleus Nucleus speckle Belongs to the WD repeat THOC6 family. transcription export complex THO complex THO complex part of transcription export complex nuclear chromosome, telomeric region RNA binding protein binding nucleus nucleoplasm mRNA processing mRNA export from nucleus apoptotic process multicellular organism development central nervous system development RNA splicing nuclear body nuclear speck negative regulation of apoptotic process viral mRNA export from host cell nucleus mRNA transport uc008ast.1 uc008ast.2 uc008ast.3 
ENSMUST00000095580.3 Mypn ENSMUST00000095580.3 myopalladin (from RefSeq NM_182992.2) ENSMUST00000095580.1 ENSMUST00000095580.2 Kiaa4170 MYPN_MOUSE NM_182992 Q5DTJ9 Q7TPW5 Q8BZ76 uc007fjy.1 uc007fjy.2 uc007fjy.3 Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. Interacts with TTN/titin, NEB, NEBL, ACTN2 and CARP. Cytoplasm Nucleus Cytoplasm, myofibril, sarcomere Cytoplasm, myofibril, sarcomere, Z line Note=Bound to sarcomere both at the Z- line periphery and in the central I-band region. Belongs to the myotilin/palladin family. Sequence=BAD90521.1; Type=Erroneous initiation; Evidence=; actin binding nucleus cytoplasm plasma membrane homophilic cell adhesion via plasma membrane adhesion molecules axon guidance cytoskeletal protein binding SH3 domain binding sarcomere Z disc axon I band sarcomere organization muscle alpha-actinin binding dendrite self-avoidance protein binding involved in cell-cell adhesion uc007fjy.1 uc007fjy.2 uc007fjy.3 
ENSMUST00000095585.11 Adgrv1 ENSMUST00000095585.11 adhesion G protein-coupled receptor V1 (from RefSeq NM_054053.4) Adgrv1 B8JJE0 B8JJE0_MOUSE ENSMUST00000095585.1 ENSMUST00000095585.10 ENSMUST00000095585.2 ENSMUST00000095585.3 ENSMUST00000095585.4 ENSMUST00000095585.5 ENSMUST00000095585.6 ENSMUST00000095585.7 ENSMUST00000095585.8 ENSMUST00000095585.9 Gpr98 NM_054053 uc007rhn.1 uc007rhn.2 uc007rhn.3 Membrane ; Multi- pass membrane protein transmembrane signaling receptor activity G-protein coupled receptor activity calcium ion binding cytoplasm cell communication cell surface receptor signaling pathway G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity sensory perception of sound cell surface membrane integral component of membrane stereocilium receptor complex synapse photoreceptor cell maintenance maintenance of animal organ identity neurological system process sensory perception of light stimulus uc007rhn.1 uc007rhn.2 uc007rhn.3 
ENSMUST00000095595.9 Zscan10 ENSMUST00000095595.9 zinc finger and SCAN domain containing 10, transcript variant 1 (from RefSeq NM_001033425.4) B7ZP53 ENSMUST00000095595.1 ENSMUST00000095595.2 ENSMUST00000095595.3 ENSMUST00000095595.4 ENSMUST00000095595.5 ENSMUST00000095595.6 ENSMUST00000095595.7 ENSMUST00000095595.8 NM_001033425 Q20D61 Q20D62 Q20D63 Q3URR7 ZSC10_MOUSE Zfp206 uc008asl.1 uc008asl.2 uc008asl.3 uc008asl.4 Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4. Interacts with POU5F1/OCT4 and SOX2. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3URR7-1; Sequence=Displayed; Name=2; IsoId=Q3URR7-2; Sequence=VSP_039228; Name=3; IsoId=Q3URR7-3; Sequence=VSP_039227; Embryonic stem (ES) cell-specific. Not expressed in adult, except in testis. Expressed throughout embryogenesis. Transcriptionally regulated by POU5F1/OCT4 and SOX2. Methylated at Gln-485 by N6AMT1. nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding negative regulation of transcription, DNA-templated metal ion binding stem cell differentiation uc008asl.1 uc008asl.2 uc008asl.3 uc008asl.4 
ENSMUST00000095606.5 Zfp213 ENSMUST00000095606.5 zinc finger protein 213 (from RefSeq NM_001033496.3) E9QAW0 E9QAW0_MOUSE ENSMUST00000095606.1 ENSMUST00000095606.2 ENSMUST00000095606.3 ENSMUST00000095606.4 NM_001033496 Zfp213 uc008asg.1 uc008asg.2 uc008asg.3 uc008asg.4 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc008asg.1 uc008asg.2 uc008asg.3 uc008asg.4 
ENSMUST00000095610.9 Akap5 ENSMUST00000095610.9 Akap5 (from geneSymbol) AK139319 Akap5 ENSMUST00000095610.1 ENSMUST00000095610.2 ENSMUST00000095610.3 ENSMUST00000095610.4 ENSMUST00000095610.5 ENSMUST00000095610.6 ENSMUST00000095610.7 ENSMUST00000095610.8 H3BIV5 H3BIV5_MOUSE uc033gdx.1 uc033gdx.2 uc033gdx.3 plasma membrane protein targeting signal transduction adenylate cyclase binding positive regulation of adenylate cyclase activity uc033gdx.1 uc033gdx.2 uc033gdx.3 
ENSMUST00000095636.2 Fpr-rs6 ENSMUST00000095636.2 formyl peptide receptor, related sequence 6 (from RefSeq NM_177316.2) ENSMUST00000095636.1 FPRS6_MOUSE NM_177316 Q3SXG2 Q71MR8 uc008apy.1 uc008apy.2 May have an olfactory function associated with the identification of pathogens or of pathogenic states. Membrane ; Multi-pass membrane protein Expressed exclusively in vomeronasal tissue (PubMed:19387439, PubMed:19497865). Expressed in 1.2 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed in brain, spleen, skeletal muscle and at high level in testis (PubMed:12459252). Belongs to the G-protein coupled receptor 1 family. Name=Protein Spotlight; Note=A sickly smell - Issue 114 of February 2010; URL="https://web.expasy.org/spotlight/back_issues/114"; complement receptor mediated signaling pathway G-protein coupled receptor activity N-formyl peptide receptor activity cell inflammatory response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane uc008apy.1 uc008apy.2 
ENSMUST00000095637.2 Fpr-rs7 ENSMUST00000095637.2 May have an olfactory function associated with the identification of pathogens or of pathogenic states. (from UniProt Q71MR7) ENSMUST00000095637.1 FPRS7_MOUSE G3X9N8 Q71MR7 uc289hlg.1 uc289hlg.2 May have an olfactory function associated with the identification of pathogens or of pathogenic states. Membrane ; Multi-pass membrane protein Expressed exclusively in vomeronasal organ (PubMed:19387439, PubMed:19497865). Expressed in 0.8 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed in heart, liver, lung, spleen smooth muscle and pancreas (PubMed:12459252). Belongs to the G-protein coupled receptor 1 family. Name=Protein Spotlight; Note=A sickly smell - Issue 114 of February 2010; URL="https://web.expasy.org/spotlight/back_issues/114"; complement receptor mediated signaling pathway G-protein coupled receptor activity N-formyl peptide receptor activity integral component of plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane uc289hlg.1 uc289hlg.2 
ENSMUST00000095651.2 Fpr-rs4 ENSMUST00000095651.2 formyl peptide receptor, related sequence 4 (from RefSeq NM_008041.2) A4FUQ5 A4QMY2 E9QPJ4 ENSMUST00000095651.1 FPRS4_MOUSE NM_008041 O88538 uc012alh.1 uc012alh.2 May have an olfactory function associated with the identification of pathogens or of pathogenic states. Cell membrane; Multi-pass membrane protein. Expressed in 0.6 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Belongs to the G-protein coupled receptor 1 family. Name=Protein Spotlight; Note=A sickly smell - Issue 114 of February 2010; URL="https://web.expasy.org/spotlight/back_issues/114"; complement receptor mediated signaling pathway G-protein coupled receptor activity N-formyl peptide receptor activity plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane uc012alh.1 uc012alh.2 
ENSMUST00000095655.4 Lmod3 ENSMUST00000095655.4 leiomodin 3 (fetal) (from RefSeq NM_001081157.2) A0AUN8 A0JP45 E9QA62 ENSMUST00000095655.1 ENSMUST00000095655.2 ENSMUST00000095655.3 LMOD3_MOUSE Lmod3 NM_001081157 uc009das.1 uc009das.2 uc009das.3 Essential for the organization of sarcomeric actin thin filaments in skeletal muscle (PubMed:25774500, PubMed:26035871). Increases the rate of actin polymerization (By similarity). May interact with tropomyosin alpha (TPM1/2) N-terminus (By similarity). Interacts with KLHL40; leading to stabilization (PubMed:24960163). Cytoplasm Cytoplasm, myofibril, sarcomere, A band Cytoplasm, myofibril, sarcomere, M line Cytoplasm, cytoskeleton Note=Highly expressed in nonstriated areas of developing myotubes, where it shows a granular cytoplasmic pattern. In sarcomeres, highly expressed in the M band region and, at lower levels, along actin thin filaments. Not detected in Z-disks. In sarcomeres, may be located near, but not at, actin thin filament pointed end. Skeletal muscle and heart-specific (at protein level). Expressed by 15.5 dpc in both skeletal muscle and heart. Expression is maintained throughout adulthood. Expression is regulated by SRF and MEF2. Ubiquitinated, leading to its degradation. Interaction with KLHL40 negatively regulates ubiquitination and degradation. Mice show severe muscle weakness and postnatal growth retardation. Skeletal muscles show the presence of nemaline bodies and have disorganized sarcomeric structures. Muscle atrophy is specific to the fast fibers. Belongs to the tropomodulin family. Sequence=AAI17773.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; actin binding actin monomer binding protein binding tropomyosin binding cytoplasm cytoskeleton striated muscle thin filament muscle contraction striated muscle contraction myofibril myofibril assembly skeletal muscle thin filament assembly M band A band actin nucleation skeletal muscle fiber development positive regulation of skeletal muscle fiber development pointed-end actin filament capping uc009das.1 uc009das.2 uc009das.3 
ENSMUST00000095664.6 Tmf1 ENSMUST00000095664.6 TATA element modulatory factor 1 (from RefSeq NM_001081111.2) Ara160 B9EKI3 E9QPJ3 ENSMUST00000095664.1 ENSMUST00000095664.2 ENSMUST00000095664.3 ENSMUST00000095664.4 ENSMUST00000095664.5 Gm153 NM_001081111 Q3UMH8 Q3UMR3 TMF1_MOUSE uc009dak.1 uc009dak.2 uc009dak.3 uc009dak.4 Potential coactivator of the androgen receptor. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER (By similarity). Mediates STAT3 degradation. Component of the SNF/SWI transcription factor complexes (By similarity). Interacts with RAB6A. Interacts with TCEB1 (By similarity). Interacts with STAT3 and FER. Interacts with TRNP1; may regulate TRNP1 proteasomal degradation. Cytoplasm Nucleus Golgi apparatus membrane Note=Concentrated at the budding structures localized at the tips of cisternae. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]. Phosphorylated by FER. Sequence=BAE26035.1; Type=Frameshift; Evidence=; Golgi membrane acrosome assembly positive regulation of cytokine production DNA binding protein binding nucleus cytoplasm endoplasmic reticulum Golgi apparatus spermatid development spermatid nucleus differentiation male gonad development negative regulation of gene expression membrane flagellated sperm motility luteinizing hormone secretion Leydig cell differentiation defense response to bacterium negative regulation of apoptotic process regulation of proteasomal protein catabolic process cellular response to organic cyclic compound positive regulation of testosterone secretion uc009dak.1 uc009dak.2 uc009dak.3 uc009dak.4 
ENSMUST00000095712.5 Slc5a7 ENSMUST00000095712.5 solute carrier family 5 (choline transporter), member 7 (from RefSeq NM_022025.4) Cht1 ENSMUST00000095712.1 ENSMUST00000095712.2 ENSMUST00000095712.3 ENSMUST00000095712.4 NM_022025 Q8BGY9 Q99PK3 Q9ESW5 SC5A7_MOUSE Slc5a7 uc008czy.1 uc008czy.2 High-affinity Na(+)-coupled choline transmembrane symporter (PubMed:11709061, PubMed:15173594). Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry (By similarity). Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion (By similarity). Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release (By similarity). SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials (PubMed:11709061, PubMed:15173594). Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity (By similarity). Reaction=choline(out) + n Na(+)(out) = choline(in) + n Na(+)(in); Xref=Rhea:RHEA:76443, ChEBI:CHEBI:15354, ChEBI:CHEBI:29101; Evidence=; Choline uptake activity is regulated by SLC5A7/CHT1 internalization (inactive form) from the cell surface and recycling of internalized SLC5A7/CHT1 into the cell surface (active form) (By similarity). Activated by extracellular chloride ion (By similarity). Specifically inhibited by nanomolar concentrations of hemicholinium 3 (PubMed:11709061, PubMed:15173594). Homooligomerizes at cell surface. Interacts with SEC14L1; may regulate SLC5A7. Q8BGY9; P05067: APP; Xeno; NbExp=2; IntAct=EBI-2010752, EBI-77613; Presynaptic cell membrane ; Multi-pass membrane protein Cell projection, axon Early endosome membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Note=Localized to motor neuron axons. Found in spinal cord, brain-stem, mid-brain and striatum (PubMed:11709061). Specific for cholinergic neurons (PubMed:11709061). The C-terminal dileucine-like motif (DKTILV) controls SLC5A7/CHT1 internalization in clathrin-coated vesicles to early endosomes as well as choline transporter activity. Phosphorylated by PKC and dephosphorylated by PP1/PP2A. Although morphologically normal at birth, knockout mice become immobile, breathe irregularly, appear cyanotic, and die within an hour. Mice had developmental changes in neuromuscular junction morphology reminiscent of changes in mutant mice lacking ACh synthesis. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. in utero embryonic development choline:sodium symporter activity protein binding early endosome plasma membrane ion transport sodium ion transport synaptic transmission, cholinergic neuromuscular synaptic transmission synaptic vesicle acetylcholine biosynthetic process choline transmembrane transporter activity symporter activity choline transport membrane integral component of membrane apical plasma membrane transmembrane transporter activity cell junction axon dendrite neuromuscular junction choline binding neurotransmitter biosynthetic process neuronal cell body perikaryon plasma membrane raft synapse clathrin-coated endocytic vesicle transmembrane transport uc008czy.1 uc008czy.2 
ENSMUST00000095715.5 Bves ENSMUST00000095715.5 blood vessel epicardial substance (from RefSeq NM_024285.3) A2RS91 Bves ENSMUST00000095715.1 ENSMUST00000095715.2 ENSMUST00000095715.3 ENSMUST00000095715.4 NM_024285 POPD1_MOUSE Pop1 Popdc1 Q8C8L3 Q9ES83 uc007ezz.1 uc007ezz.2 uc007ezz.3 Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3 (PubMed:20057356). Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT (PubMed:18541910). Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (PubMed:11839816). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury (PubMed:24066022). Homodimer. Homodimerization requires the C-terminus cytoplasmic region (By similarity). Interacts (via the C-terminus cytoplasmic tail) with TJP1. Interacts (via the C-terminus cytoplasmic tail) with ARHGEF25/GEFT (via the DH domain). Interacts (via the C- terminus cytoplasmic tail) with VAMP3. Interacts with KCNK2; the interaction enhances KCNK2 surface expression and is inhibited by cAMP (PubMed:22354168, PubMed:26642364). Interacts with CAV3 (PubMed:24066022). Q9ES83; Q9CWR0: Arhgef25; NbExp=2; IntAct=EBI-7705661, EBI-15708245; Q9ES83; P63025: Vamp3; Xeno; NbExp=3; IntAct=EBI-7705661, EBI-7705696; Lateral cell membrane Cell junction, tight junction Membrane ; Multi-pass membrane protein Cell membrane, sarcolemma Membrane, caveola Note=Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Detected at cell-cell contact but never observed at the free surface of epithelial cells (By similarity). Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle. Expressed in epithelial cells, skeletal muscle, heart and intestinal smooth muscle (at protein level). Expressed in fetal and adult heart and skeletal muscle. Expressed in the mesoderm of the cardiac crescent at 9.5 dpc. Expressed in cardiac myocytes of the sinoatrial compartment and some restricted areas of the dorsal part of the ventricle chambers at 10.5 dpc and 12.5 dpc. Expressed in branchial arches, myotome and in a posterior domain in the limb at 10.5 dpc. Expressed in the heart, mainly in the compact layer myocardium, peridigital mesenchyme, the somites of the tail bud, the smooth muscle cells of the trachea and the developing bronchial tree, the smooth muscle cells lining the digestive tract, the dorsal root ganglia and the pancreas anlage at 13.5 dpc (at protein level). Expressed in the sinoatrial compartment and some restricted areas in the dorsal part of the ventricle at 9.5 dpc, 10.5 dpc and 11.5 dpc. At 12.5 dpc, expression was observed in the ventral half of the ventricle where it was limited to the subepicardial compact layer. Skeletal muscle regeneration appears to be less efficient and delayed (PubMed:11839816). Knockout mice are deficient to adapt heart rate to physiological stress, this deficiency develops in older mice. They show severe sinus node dysfunction with long pauses and intercurrent periods of normal synus rhythm. The sinus node structure is abnormal with a loss of pacemaker tissue from the inferior part of the sinus node and a compact structure of the superior sinus node (PubMed:22354168). They have inpaired functional recovery after ischemia/reperfusion injury (PubMed:24066022). Belongs to the popeye family. nucleotide binding positive regulation of receptor recycling regulation of heart rate hematopoietic progenitor cell differentiation response to ischemia structural molecule activity protein binding plasma membrane caveola bicellular tight junction cell adhesion multicellular organism development heart development skeletal muscle tissue development regulation of cell shape membrane integral component of membrane vesicle-mediated transport lateral plasma membrane cell junction cAMP binding cell projection membrane substrate adhesion-dependent cell spreading positive regulation of locomotion sarcolemma regulation of membrane potential regulation of GTPase activity vesicle docking striated muscle cell differentiation sinoatrial node cell development cell migration involved in heart development epithelial cell-cell adhesion regulation of endocytic recycling uc007ezz.1 uc007ezz.2 uc007ezz.3 
ENSMUST00000095725.11 Pdss2 ENSMUST00000095725.11 prenyl (solanesyl) diphosphate synthase, subunit 2, transcript variant 1 (from RefSeq NM_027772.2) B2RWA7 B2RWF3 DLP1_MOUSE Dlp1 ENSMUST00000095725.1 ENSMUST00000095725.10 ENSMUST00000095725.2 ENSMUST00000095725.3 ENSMUST00000095725.4 ENSMUST00000095725.5 ENSMUST00000095725.6 ENSMUST00000095725.7 ENSMUST00000095725.8 ENSMUST00000095725.9 NM_027772 Pdss2 Q33DR3 Q3USU6 Q9D3K7 uc007ezi.1 uc007ezi.2 uc007ezi.3 uc007ezi.4 Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone (PubMed:16262699). Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9) and ubiquinone-10 (Q10) respectively (PubMed:16262699). The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry (PubMed:16262699). May play a role during cerebellar development (PubMed:21871565). May regulate mitochondrial respiratory chain function (PubMed:18437205). Reaction=(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate; Xref=Rhea:RHEA:27802, ChEBI:CHEBI:33019, ChEBI:CHEBI:60721, ChEBI:CHEBI:128769, ChEBI:CHEBI:175763; EC=2.5.1.91; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27803; Evidence=; Reaction=(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate; Xref=Rhea:RHEA:55364, ChEBI:CHEBI:33019, ChEBI:CHEBI:58391, ChEBI:CHEBI:128769, ChEBI:CHEBI:175763; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55365; Evidence=; Cofactor biosynthesis; ubiquinone biosynthesis. Heterotetramer composed of 2 PDSS1/DPS1 and 2 PDSS2/DLP1 subunits. Mitochondrion Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q33DR3-1; Sequence=Displayed; Name=2; IsoId=Q33DR3-2; Sequence=VSP_017104, VSP_017105; Name=3; IsoId=Q33DR3-3; Sequence=VSP_017102, VSP_017103; Homozygous mice for PDSS2 are embryonic lethal (PubMed:18437205, PubMed:21871565). The oldest PDSS2 embryo identified is at E9.5, and its morphology resembles normal E6.5 mouse embryo, so the development of mutant embryo may be blocked at late gastrula stage (PubMed:18437205, PubMed:21871565). Conditional knockout mice lacking PDSS2 in cerebellum show severe cerebellum hypoplasia during cerebellum development, whereas conditional knockout mice lacking PDSS2 in Purkinje cells at postnatal stages leads to the development of cerebellar ataxia (PubMed:21871565). Conditional knockout mice lacking PDSS2 in glomeruli show interstitial nephritis characterized by greatly dilated tubules and extensive interstitial infiltration associated with hypercholesterolemia (PubMed:18437205). Liver-conditional knockout mice have no overt disease but their livers have undetectable COQ9 levels, impaired respiratory capacity, and significantly altered intermediary metabolism (PubMed:18437205). Belongs to the FPP/GGPP synthase family. trans-hexaprenyltranstransferase activity protein binding mitochondrion cytosol ubiquinone biosynthetic process isoprenoid biosynthetic process transferase activity protein heterodimerization activity regulation of body fluid levels transferase complex trans-octaprenyltranstransferase activity uc007ezi.1 uc007ezi.2 uc007ezi.3 uc007ezi.4 
ENSMUST00000095726.11 Tcp10a ENSMUST00000095726.11 t-complex protein 10a, transcript variant 1 (from RefSeq NM_011553.4) ENSMUST00000095726.1 ENSMUST00000095726.10 ENSMUST00000095726.2 ENSMUST00000095726.3 ENSMUST00000095726.4 ENSMUST00000095726.5 ENSMUST00000095726.6 ENSMUST00000095726.7 ENSMUST00000095726.8 ENSMUST00000095726.9 Gm10326 NM_011553 Q80W76 Q80W76_MOUSE Tcp10a Tcp10b uc029szn.1 uc029szn.2 uc029szn.3 Belongs to the TCP10 family. transcription corepressor activity nucleus centriole biological_process negative regulation of nucleic acid-templated transcription uc029szn.1 uc029szn.2 uc029szn.3 
ENSMUST00000095737.5 Akap6 ENSMUST00000095737.5 A kinase anchor protein 6 (from RefSeq NM_198111.2) Akap6 E9Q9K8 E9Q9K8_MOUSE ENSMUST00000095737.1 ENSMUST00000095737.2 ENSMUST00000095737.3 ENSMUST00000095737.4 NM_198111 uc007nnm.1 uc007nnm.2 uc007nnm.3 E9Q9K8; Q8VCC8: Rapgef3; NbExp=2; IntAct=EBI-6902745, EBI-6902706; positive regulation of protein phosphorylation protein binding nucleus nuclear envelope cytoplasm caveola negative regulation of adenylate cyclase activity adenylate cyclase binding regulation of protein kinase A signaling junctional sarcoplasmic reticulum membrane intercalated disc sarcoplasmic reticulum enzyme binding positive regulation of cell growth T-tubule nuclear membrane macromolecular complex protein kinase A regulatory subunit binding cellular protein complex localization calcium channel complex sarcolemma protein anchor ion channel binding positive regulation of translation perinuclear region of cytoplasm protein kinase A binding positive regulation of release of sequestered calcium ion into cytosol protein phosphatase 2A binding binding, bridging regulation of membrane repolarization positive regulation of ryanodine-sensitive calcium-release channel activity positive regulation of cell growth involved in cardiac muscle cell development positive regulation of calcineurin-NFAT signaling cascade cellular response to cAMP cellular response to cytokine stimulus cellular response to epinephrine stimulus regulation of cardiac muscle cell contraction positive regulation of potassium ion transmembrane transport regulation of relaxation of cardiac muscle positive regulation of delayed rectifier potassium channel activity positive regulation of cAMP-dependent protein kinase activity uc007nnm.1 uc007nnm.2 uc007nnm.3 
ENSMUST00000095749.6 Mfsd4b3-ps ENSMUST00000095749.6 major facilitator superfamily domain containing 4B3, pseudogene (from RefSeq NR_160808.1) ENSMUST00000095749.1 ENSMUST00000095749.2 ENSMUST00000095749.3 ENSMUST00000095749.4 ENSMUST00000095749.5 NR_160808 uc007ewi.1 uc007ewi.2 uc007ewi.3 uc007ewi.4 uc007ewi.5 uc007ewi.1 uc007ewi.2 uc007ewi.3 uc007ewi.4 uc007ewi.5 
ENSMUST00000095753.9 Tia1 ENSMUST00000095753.9 cytotoxic granule-associated RNA binding protein 1, transcript variant 1 (from RefSeq NM_011585.4) ENSMUST00000095753.1 ENSMUST00000095753.2 ENSMUST00000095753.3 ENSMUST00000095753.4 ENSMUST00000095753.5 ENSMUST00000095753.6 ENSMUST00000095753.7 ENSMUST00000095753.8 NM_011585 Q564E7 Q564E7_MOUSE Tia1 uc009crp.1 uc009crp.2 uc009crp.3 nucleic acid binding RNA binding nucleus nucleoplasm cytoplasm cytosol cytoplasmic stress granule regulation of mRNA splicing, via spliceosome nuclear stress granule protein localization to cytoplasmic stress granule positive regulation of epithelial cell apoptotic process ribonucleoprotein complex uc009crp.1 uc009crp.2 uc009crp.3 
ENSMUST00000095755.4 Usp51 ENSMUST00000095755.4 ubiquitin specific protease 51 (from RefSeq NM_001137547.1) B1AY15 ENSMUST00000095755.1 ENSMUST00000095755.2 ENSMUST00000095755.3 NM_001137547 UBP51_MOUSE Usp51 uc009uqp.1 uc009uqp.2 uc009uqp.3 uc009uqp.4 uc009uqp.5 Deubiquitinates histone H2A at 'Lys-13' and 'Lys-15' and regulates DNA damage response. USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1 foci. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with H2A. Chromosome Note=Dissociates from chromatin immediately after DNA damage and reassociates with chromatin following DNA repair. Belongs to the peptidase C19 family. chromatin binding thiol-dependent ubiquitin-specific protease activity chromosome DNA repair proteolysis ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus peptidase activity cysteine-type peptidase activity zinc ion binding regulation of cell cycle process regulation of double-strand break repair via homologous recombination histone deubiquitination protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity histone binding metal ion binding regulation of response to DNA damage stimulus regulation of double-strand break repair via nonhomologous end joining uc009uqp.1 uc009uqp.2 uc009uqp.3 uc009uqp.4 uc009uqp.5 
ENSMUST00000095757.4 Nat8f4 ENSMUST00000095757.4 N-acetyltransferase 8 (GCN5-related) family member 4, transcript variant 1 (from RefSeq NM_029331.3) 1700019G17Rik ENSMUST00000095757.1 ENSMUST00000095757.2 ENSMUST00000095757.3 G5E8L3 G5E8L3_MOUSE NM_029331 Nat8f4 uc009cqj.1 uc009cqj.2 uc009cqj.3 uc009cqj.4 Belongs to the camello family. molecular_function cellular_component N-acetyltransferase activity biological_process membrane integral component of membrane uc009cqj.1 uc009cqj.2 uc009cqj.3 uc009cqj.4 
ENSMUST00000095758.3 Trappc3l ENSMUST00000095758.3 trafficking protein particle complex 3 like (from RefSeq NM_001162937.1) Bet3l ENSMUST00000095758.1 ENSMUST00000095758.2 NM_001162937 Q4KL14 TPC3L_MOUSE uc007euo.1 uc007euo.2 May play a role in vesicular transport from endoplasmic reticulum to Golgi. Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12 (By similarity). Golgi apparatus, cis-Golgi network Endoplasmic reticulum Belongs to the TRAPP small subunits family. BET3 subfamily. endoplasmic reticulum Golgi apparatus cytosol ER to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport vesicle-mediated transport TRAPP complex cis-Golgi network membrane Golgi vesicle transport Rab guanyl-nucleotide exchange factor activity uc007euo.1 uc007euo.2 
ENSMUST00000095759.5 Egr4 ENSMUST00000095759.5 early growth response 4 (from RefSeq NM_020596.3) EGR4_MOUSE ENSMUST00000095759.1 ENSMUST00000095759.2 ENSMUST00000095759.3 ENSMUST00000095759.4 NM_020596 Q9WUF2 uc009cpy.1 uc009cpy.2 uc009cpy.3 Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity). Nucleus. Belongs to the EGR C2H2-type zinc-finger protein family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleic acid binding DNA binding nucleus regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc009cpy.1 uc009cpy.2 uc009cpy.3 
ENSMUST00000095760.3 Lsmem1 ENSMUST00000095760.3 leucine-rich single-pass membrane protein 1 (from RefSeq NM_001033437.2) ENSMUST00000095760.1 ENSMUST00000095760.2 Gm889 LSME1_MOUSE NM_001033437 Q3UQS2 Q3UZ75 uc007nkx.1 uc007nkx.2 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UQS2-1; Sequence=Displayed; Name=2; IsoId=Q3UQS2-2; Sequence=VSP_029105; molecular_function cytosol biological_process membrane integral component of membrane uc007nkx.1 uc007nkx.2 
ENSMUST00000095767.11 Etv1 ENSMUST00000095767.11 ets variant 1, transcript variant 1 (from RefSeq NM_007960.5) ENSMUST00000095767.1 ENSMUST00000095767.10 ENSMUST00000095767.2 ENSMUST00000095767.3 ENSMUST00000095767.4 ENSMUST00000095767.5 ENSMUST00000095767.6 ENSMUST00000095767.7 ENSMUST00000095767.8 ENSMUST00000095767.9 Etv1 NM_007960 Q549J8 Q549J8_MOUSE uc033gdc.1 uc033gdc.2 uc033gdc.3 Nucleus Belongs to the ETS family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated transcription from RNA polymerase II promoter sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter peripheral nervous system neuron development uc033gdc.1 uc033gdc.2 uc033gdc.3 
ENSMUST00000095774.3 Cdhr3 ENSMUST00000095774.3 cadherin-related family member 3 (from RefSeq NM_001024478.1) B2RSL6 CDHR3_MOUSE Cdh28 ENSMUST00000095774.1 ENSMUST00000095774.2 NM_001024478 Q8BL00 uc007nij.1 uc007nij.2 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cell membrane ; Single-pass type I membrane protein calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc007nij.1 uc007nij.2 
ENSMUST00000095784.3 Moxd1 ENSMUST00000095784.3 monooxygenase, DBH-like 1 (from RefSeq NM_021509.5) Dbhr ENSMUST00000095784.1 ENSMUST00000095784.2 MOXD1_MOUSE Mox NM_021509 Q6PFA8 Q8BUZ7 Q8R394 Q9CXI3 Q9JJA6 uc007equ.1 uc007equ.2 uc007equ.3 Name=Cu(2+); Xref=ChEBI:CHEBI:29036; Evidence=; Note=Binds 2 copper ions per subunit. ; Endoplasmic reticulum membrane ; Single-pass type I membrane protein Broadly exprressed, with highest levels in salivary gland and ovary. N-glycosylated. Belongs to the copper type II ascorbate-dependent monooxygenase family. Sequence=BAC38265.1; Type=Frameshift; Evidence=; catalytic activity monooxygenase activity dopamine beta-monooxygenase activity copper ion binding extracellular space cytoplasm endoplasmic reticulum endoplasmic reticulum membrane octopamine biosynthetic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen secretory granule membrane dopamine catabolic process norepinephrine biosynthetic process metal ion binding oxidation-reduction process uc007equ.1 uc007equ.2 uc007equ.3 
ENSMUST00000095786.6 Pole4 ENSMUST00000095786.6 polymerase (DNA-directed), epsilon 4 (p12 subunit), transcript variant 1 (from RefSeq NM_025882.3) DPOE4_MOUSE ENSMUST00000095786.1 ENSMUST00000095786.2 ENSMUST00000095786.3 ENSMUST00000095786.4 ENSMUST00000095786.5 NM_025882 Q3TJ13 Q9CQ36 uc009clk.1 uc009clk.2 uc009clk.3 Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4. Interaction with POLE3 is a prerequisite for further binding with POLE and POLE2. Nucleus DNA binding transcription factor activity, sequence-specific DNA binding DNA-directed DNA polymerase activity nucleus Ada2/Gcn5/Ada3 transcription activator complex regulation of transcription, DNA-templated epsilon DNA polymerase complex transferase activity nucleotidyltransferase activity histone H3 acetylation protein heterodimerization activity DNA biosynthetic process uc009clk.1 uc009clk.2 uc009clk.3 
ENSMUST00000095793.3 Rnf17 ENSMUST00000095793.3 ring finger protein 17 (from RefSeq NM_001033043.1) ENSMUST00000095793.1 ENSMUST00000095793.2 NM_001033043 Q3T4H2 Q3T4H3 Q4FZG6 Q8CDR4 Q99MV7 Q9QXQ2 RNF17_MOUSE uc007uca.1 uc007uca.2 uc007uca.3 uc007uca.4 Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis. Interacts with MXD1, MXD3, MXD4, MXI1 and PIWIL1. Self- associates. Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm. Component of a nuage in male germ cells (an electron- dense spherical cytoplasmic body present in late pachytene and diplotene spermatocytes and in elonging spermatids). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=RNF17L; IsoId=Q99MV7-1; Sequence=Displayed; Name=2; Synonyms=RNF17S; IsoId=Q99MV7-2; Sequence=VSP_033080, VSP_033081; Name=3; IsoId=Q99MV7-3; Sequence=VSP_033077; Name=4; IsoId=Q99MV7-4; Sequence=VSP_033078, VSP_033079; Expressed at high levels in adult testis. Expressed in male germ cells (at protein level). Expressed at lower levels in adult thyroid, submaxillary gland, ovary and epididymis. Male mice are sterile, exhibit a complete arrest in round spermatids and fail to produce sperm. [Isoform 2]: Major. Sequence=AAF01336.1; Type=Frameshift; Evidence=; nucleus cytoplasm multicellular organism development spermatogenesis spermatid development cell differentiation protein homodimerization activity metal ion binding uc007uca.1 uc007uca.2 uc007uca.3 uc007uca.4 
ENSMUST00000095797.6 Spin1 ENSMUST00000095797.6 spindlin 1, transcript variant 2 (from RefSeq NM_146043.5) ENSMUST00000095797.1 ENSMUST00000095797.2 ENSMUST00000095797.3 ENSMUST00000095797.4 ENSMUST00000095797.5 NM_146043 Q3TLC3 Q3UT05 Q61142 Q91VG8 SPIN1_MOUSE Spin uc007qly.1 uc007qly.2 uc007qly.3 uc007qly.4 Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (By similarity). Overexpression induces metaphase arrest and chromosomal instability (PubMed:18543248). Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (PubMed:23894536). Homodimer; may form higher-order oligomers. Interacts with TCF7L2/TCF4; the interaction is direct (By similarity). Interacts with HABP4 and SERBP1 (PubMed:23894536). Interacts with C11orf84/SPINDOC (By similarity). Nucleus Cytoplasm, cytoskeleton, spindle Nucleus, nucleolus Note=Associates with the meiotic spindle. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61142-1; Sequence=Displayed; Name=2; IsoId=Q61142-2; Sequence=VSP_017942; Oocyte, egg, and very early embryo; not in the 8-, and 16-cell stage of the embryo. Isoform 1: Present in testis. Isoform 1 is more highly expressed in adult testes compared with newborn testes (at protein level). Gametogenesis. Synthesized from maternal transcripts but not from the zygote genome. The 3 tudor-like domains (also named Spin/Ssty repeats) specifically recognize and bind methylated histones. H3K4me3 and H3R8me2a are recognized by tudor-like domains 2 and 1, respectively. Phosphorylated during oocyte meiotic maturation. Post-translationally modified during the first mitotic cell cycle. Early postnatal lethality. Ovarian folliculogenesis and oocyte growth appear normal but fully grown oocytes show defects in resuming meiosis. Belongs to the SPIN/STSY family. DNA binding nucleus nucleoplasm nucleolus cytoplasm spindle cytosol cytoskeleton chromatin organization cell cycle female meiotic division multicellular organism development gamete generation rRNA transcription Wnt signaling pathway positive regulation of Wnt signaling pathway nuclear membrane methylated histone binding positive regulation of transcription, DNA-templated meiotic cell cycle uc007qly.1 uc007qly.2 uc007qly.3 uc007qly.4 
ENSMUST00000095798.2 Mcpt9 ENSMUST00000095798.2 mast cell protease 9 (from RefSeq NM_010782.3) ENSMUST00000095798.1 MCPT9_MOUSE NM_010782 O35164 uc007ubj.1 uc007ubj.2 Selectively expressed in uterine mast cells. Belongs to the peptidase S1 family. Granzyme subfamily. serine-type endopeptidase activity extracellular space cytoplasm proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc007ubj.1 uc007ubj.2 
ENSMUST00000095806.10 Map3k5 ENSMUST00000095806.10 mitogen-activated protein kinase kinase kinase 5 (from RefSeq NM_008580.4) Ask1 ENSMUST00000095806.1 ENSMUST00000095806.2 ENSMUST00000095806.3 ENSMUST00000095806.4 ENSMUST00000095806.5 ENSMUST00000095806.6 ENSMUST00000095806.7 ENSMUST00000095806.8 ENSMUST00000095806.9 M3K5_MOUSE Mekk5 NM_008580 O35099 Q14AY5 uc007enm.1 uc007enm.2 uc007enm.3 uc007enm.4 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by various stressors, including oxidative stress, endoplasmic reticulum stress, and calcium overload, as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) and lipopolysaccharide (LPS). Homophilic association of MAP3K5/ASK1 through the C-terminal coiled-coil domains and the heteromeric complex formation of MAP3K5/ASK1 with the reduced form of thioredoxin (TXN), constitutes an inactive form of the kinase. Upon ROS-induced dissociation of TXN from MAP3K5/ASK1, TRAF2 and TRAF6 are reciprocally recruited to MAP3K5/ASK1 and form the active MAP3K5/ASK1 signalosome, in which TRAF2 and TRAF6 appear to facilitate the active configuration of MAP3K5/ASK1. MAP3K5/ASK1 activity is also regulated through several phosphorylation and dephosphorylation events. Thr-845 is an activating phosphorylation site that is autophosphorylated and phosphorylated by MAP3K6/ASK2 and dephosphorylated by PPP5C. Ser-90 and Ser-1040 are inactivating phosphorylation sites, the former of which is phosphorylated by AKT1. Phosphorylation of Ser-973 induces association of MAP3K5/ASK1 with the 14-3-3 family proteins, which suppresses MAP3K5/ASK1 activity. Calcium/calmodulin-activated protein phosphatase calcineurin (PPP3CA) has been shown to directly dephosphorylate this site. SOCS1 binds to ASK1 by recognizing phosphorylation of Tyr-725 and induces MAP3K5/ASK1 degradation in endothelial cells. Also dephosphorylated and activated by PGAM5. Contains an N-terminal autoinhibitory domain. Homodimer when inactive (By similarity). Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF (By similarity). This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis (By similarity). Interacts with SOCS1 which recognizes phosphorylation of Tyr-725 and induces MAP3K5/ASK1 degradation in endothelial cells (By similarity). Interacts with the 14-3-3 family proteins such as YWHAB, YWHAE, YWHAQ, YWHAH, YWHAZ and SFN (By similarity). Interacts with ARRB2, BIRC2, DAB2IP, IGF1R, MAP3K6/ASK2, PIM1, PGAM5, SOCS1, STUB1, TRAF2 and TXN (By similarity). Interacts with ERN1 in a TRAF2-dependent manner (By similarity). Interacts with calcineurin subunit PPP3R1, PPP5C, PPM1L and TRAF6 (PubMed:15864310, PubMed:16648474, PubMed:17456047, PubMed:22399290). Interacts (via N-terminus) with RAF1 and this interaction inhibits the proapoptotic function of MAP3K5. Interacts with DAB2IP (via N-terminus C2 domain); the interaction occurs in a TNF-alpha-dependent manner (By similarity).Interacts with DUSP13A; may positively regulate apoptosis (By similarity). Interacts with PPIA/CYPA (By similarity). Interacts with PRMT1; the interaction results in MAP3K5 methylation by PRMT1 which inhibits MAP3K5 activation (By similarity). Interacts with TRAF2; the interaction is inhibited by PRMT1 (By similarity). Interacts with TRIM48 (By similarity). O35099; Q63810: Ppp3r1; NbExp=3; IntAct=EBI-777493, EBI-6666164; O35099; Q9D1C8: Vps28; NbExp=3; IntAct=EBI-777493, EBI-309205; Cytoplasm Endoplasmic reticulum Note=Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region. Expressed in various adult mouse tissues including heart, brain, lung, liver and kidney. Ser-90 and Ser-1040 are inactivating phosphorylation sites, the former of which is phosphorylated by AKT1 (By similarity). Phosphorylated at Ser-973 which induces association of MAP3K5/ASK1 with the 14-3-3 family proteins and suppresses MAP3K5/ASK1 activity (PubMed:16648474). Calcineurin (CN) dephosphorylates this site. Also dephosphorylated and activated by PGAM5 (By similarity). Phosphorylated at Thr-845 through autophosphorylation and by MAP3K6/ASK2 which leads to activation (PubMed:11920685, PubMed:18948261, PubMed:22399290). Thr- 845 is dephosphorylated by PPP5C (PubMed:22399290). Phosphorylation at Ser-973 in response to oxidative stress is negatively regulated by PPIA/CYPA (By similarity). Ubiquitinated. Tumor necrosis factor (TNF) induces TNFR2-dependent ubiquitination, leading to proteasomal degradation. Ubiquitinated by RC3H2 in a TRIM48-dependent manner. Methylation at Arg-85 and Arg-87 by PRMT1 promotes association of MAP3K5 with thioredoxin and negatively regulates MAP3K5 association with TRAF2, inhibiting MAP3K5 activation. Methylation is blocked by ubiquitination of PRMT1 by TRIM48. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. MAPK cascade nucleotide binding activation of MAPKK activity activation of MAPK activity magnesium ion binding positive regulation of protein phosphorylation immune system process response to ischemia protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity protein binding ATP binding cytoplasm endoplasmic reticulum cytosol protein phosphorylation apoptotic process JNK cascade intrinsic apoptotic signaling pathway in response to oxidative stress external side of plasma membrane positive regulation of cardiac muscle cell apoptotic process regulation of cell death kinase activity phosphorylation transferase activity protein kinase binding protein phosphatase binding protein domain specific binding macromolecular complex cellular response to amino acid starvation response to endoplasmic reticulum stress p38MAPK cascade wound healing identical protein binding protein homodimerization activity positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of JUN kinase activity innate immune response positive regulation of myoblast differentiation positive regulation of transcription, DNA-templated positive regulation of JNK cascade metal ion binding stress-activated MAPK cascade intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to hydrogen peroxide cellular response to tumor necrosis factor endothelial cell apoptotic process programmed necrotic cell death positive regulation of p38MAPK cascade positive regulation of neuron death cellular response to reactive nitrogen species protein kinase complex positive regulation of vascular smooth muscle cell proliferation IRE1-TRAF2-ASK1 complex uc007enm.1 uc007enm.2 uc007enm.3 uc007enm.4 
ENSMUST00000095823.9 2410004P03Rik ENSMUST00000095823.9 RIKEN cDNA 2410004P03 gene, transcript variant 1 (from RefSeq NM_001201332.2) 2410004P03Rik D3Z430 D3Z430_MOUSE ENSMUST00000095823.1 ENSMUST00000095823.2 ENSMUST00000095823.3 ENSMUST00000095823.4 ENSMUST00000095823.5 ENSMUST00000095823.6 ENSMUST00000095823.7 ENSMUST00000095823.8 NM_001201332 uc007ncm.1 uc007ncm.2 uc007ncm.3 uc007ncm.4 molecular_function cellular_component biological_process uc007ncm.1 uc007ncm.2 uc007ncm.3 uc007ncm.4 
ENSMUST00000095852.5 Grid2 ENSMUST00000095852.5 glutamate receptor, ionotropic, delta 2, transcript variant 1 (from RefSeq NM_008167.3) A4QPG1 ENSMUST00000095852.1 ENSMUST00000095852.2 ENSMUST00000095852.3 ENSMUST00000095852.4 GRID2_MOUSE NM_008167 Q61625 uc009cdz.1 uc009cdz.2 uc009cdz.3 Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber- Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex. Tetramer; dimer of dimers (By similarity). Interacts with EML2, MAGI2 (via PDZ domains) and AP4M1 (By similarity). Interacts with BECN1, GOPC, GRID2IP, SHANK1 and SHANK2 (PubMed:12372286, PubMed:15207857, PubMed:17027646). Interacts with CBLN2, but not with CBLN4 (PubMed:22220752). Interacts with CBLN1 (via C1q domain); the interaction is CBLN1-NRX1 complex formation-dependent; CBLN1-binding is calcium-independent; CBLN1 hexamers anchor GRID2 N-terminal domain dimers to monomeric NRXN1 isoform beta; promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (PubMed:20395510, PubMed:21410790, PubMed:22220752, PubMed:29782851). Q61625; Q9R171: Cbln1; NbExp=8; IntAct=EBI-2794106, EBI-2794140; Q61625; Q8BH60: Gopc; NbExp=5; IntAct=EBI-2794106, EBI-296357; Q61625; D3YZU1: Shank1; NbExp=3; IntAct=EBI-2794106, EBI-2314988; Q61625; Q80Z38: Shank2; NbExp=10; IntAct=EBI-2794106, EBI-770338; Q61625; Q9WV48: Shank1; Xeno; NbExp=5; IntAct=EBI-2794106, EBI-80909; Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi- pass membrane protein Expressed selectively in cerebellar Purkinje cells where it is localized in dendritic spines. The PDZ-binding motif mediates interaction with GOPC. Note=Defects in Grid2 are the cause of the Lurcher phenotype. Heterozygous animals display a characteristic swaying of the hind quarters and jerky up and down movements following cerebellar Purkinje cell degeneration during postnatal development. Homozygous animals die shortly after birth because of a massive loss of midbrain and hindbrain neurons during late embryogenesis. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily. ionotropic glutamate receptor activity ion channel activity protein binding plasma membrane ion transport heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules glutamate receptor activity ionotropic glutamate receptor complex regulation of neuron projection development postsynaptic density ligand-gated ion channel activity membrane integral component of membrane cerebellar granule cell differentiation cell junction PDZ domain binding ion transmembrane transport cellular protein localization ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic somatodendritic compartment signaling receptor activity identical protein binding dendritic spine regulation of neuron apoptotic process synapse postsynaptic membrane modulation of synaptic transmission positive regulation of synapse assembly excitatory postsynaptic potential prepulse inhibition scaffold protein binding postsynaptic density membrane glutamatergic synapse integral component of postsynaptic density membrane positive regulation of long term synaptic depression transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential excitatory synapse assembly regulation of presynapse assembly uc009cdz.1 uc009cdz.2 uc009cdz.3 
ENSMUST00000095863.10 Slc7a15 ENSMUST00000095863.10 solute carrier family 7 (cationic amino acid transporter, y+ system), member 15, transcript variant 1 (from RefSeq NM_001038660.2) Arpat ENSMUST00000095863.1 ENSMUST00000095863.2 ENSMUST00000095863.3 ENSMUST00000095863.4 ENSMUST00000095863.5 ENSMUST00000095863.6 ENSMUST00000095863.7 ENSMUST00000095863.8 ENSMUST00000095863.9 NM_001038660 Q50E62 Q50E62_MOUSE Slc7a15 uc007mzs.1 uc007mzs.2 uc007mzs.3 uc007mzs.4 Membrane ; Multi- pass membrane protein amino acid transmembrane transport protein binding amino acid transport amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity membrane integral component of membrane transmembrane transporter activity macromolecular complex transmembrane transport L-alpha-amino acid transmembrane transport uc007mzs.1 uc007mzs.2 uc007mzs.3 uc007mzs.4 
ENSMUST00000095874.3 Ulbp3 ENSMUST00000095874.3 Ulbp3 (from geneSymbol) AK136660 ENSMUST00000095874.1 ENSMUST00000095874.2 uc287pfp.1 uc287pfp.2 uc287pfp.1 uc287pfp.2 
ENSMUST00000095893.11 Armt1 ENSMUST00000095893.11 acidic residue methyltransferase 1 (from RefSeq NM_024261.2) A6H630 ARMT1_MOUSE Armt1 ENSMUST00000095893.1 ENSMUST00000095893.10 ENSMUST00000095893.2 ENSMUST00000095893.3 ENSMUST00000095893.4 ENSMUST00000095893.5 ENSMUST00000095893.6 ENSMUST00000095893.7 ENSMUST00000095893.8 ENSMUST00000095893.9 NM_024261 Q499H1 Q99M05 Q9D9L4 uc007egy.1 uc007egy.2 uc007egy.3 Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1- phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity). Reaction=beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate; Xref=Rhea:RHEA:35603, ChEBI:CHEBI:15377, ChEBI:CHEBI:37721, ChEBI:CHEBI:43474, ChEBI:CHEBI:138881; Evidence=; Reaction=beta-D-fructose 6-phosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone; Xref=Rhea:RHEA:28002, ChEBI:CHEBI:16016, ChEBI:CHEBI:57634, ChEBI:CHEBI:59776; Evidence=; Reaction=L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L- glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:24452, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:10311, ChEBI:CHEBI:29973, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:82795; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Evidence=; Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=A6H630-1; Sequence=Displayed; Name=2; IsoId=A6H630-2; Sequence=VSP_036138, VSP_036139; Name=3; IsoId=A6H630-3; Sequence=VSP_036133, VSP_036135, VSP_036136; Name=4; IsoId=A6H630-4; Sequence=VSP_036134, VSP_036137; Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. Automethylated. Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily. Human C6orf211 has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (By similarity). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (By similarity). cellular_component protein methylation cellular response to DNA damage stimulus methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity dephosphorylation transferase activity hydrolase activity phosphatase activity enzyme binding methylation metal ion binding protein carboxyl O-methyltransferase activity regulation of response to DNA damage stimulus uc007egy.1 uc007egy.2 uc007egy.3 
ENSMUST00000095903.9 1110002L01Rik ENSMUST00000095903.9 1110002L01Rik (from geneSymbol) AK035515 ENSMUST00000095903.1 ENSMUST00000095903.2 ENSMUST00000095903.3 ENSMUST00000095903.4 ENSMUST00000095903.5 ENSMUST00000095903.6 ENSMUST00000095903.7 ENSMUST00000095903.8 uc007mwo.1 uc007mwo.2 uc007mwo.3 uc007mwo.4 uc007mwo.5 uc007mwo.6 uc007mwo.1 uc007mwo.2 uc007mwo.3 uc007mwo.4 uc007mwo.5 uc007mwo.6 
ENSMUST00000095914.7 Dusp22 ENSMUST00000095914.7 dual specificity phosphatase 22, transcript variant 1 (from RefSeq NM_001037955.4) DUS22_MOUSE ENSMUST00000095914.1 ENSMUST00000095914.2 ENSMUST00000095914.3 ENSMUST00000095914.4 ENSMUST00000095914.5 ENSMUST00000095914.6 NM_001037955 Q5SQN9 Q5SQP0 Q99N11 uc007pyx.1 uc007pyx.2 uc007pyx.3 uc007pyx.4 Activates the Jnk signaling pathway. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Monomer. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99N11-1; Sequence=Displayed; Name=2; IsoId=Q99N11-2; Sequence=VSP_019615; Myristoylation regulates subcellular location, and is necessary for activation of JNK. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. The publication has been retracted as they duplicated images. Sequence=CAI24592.1; Type=Erroneous gene model prediction; Evidence=; negative regulation of transcription from RNA polymerase II promoter negative regulation of T cell mediated immunity phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity protein binding nucleus cytoplasm cytosol plasma membrane protein dephosphorylation transforming growth factor beta receptor signaling pathway protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity negative regulation of cell migration filamentous actin peptidyl-tyrosine dephosphorylation regulation of cell proliferation positive regulation of JNK cascade negative regulation of T cell receptor signaling pathway negative regulation of T cell activation negative regulation of focal adhesion assembly cellular response to epidermal growth factor stimulus negative regulation of non-membrane spanning protein tyrosine kinase activity protein tyrosine kinase binding uc007pyx.1 uc007pyx.2 uc007pyx.3 uc007pyx.4 
ENSMUST00000095916.3 Gm5800 ENSMUST00000095916.3 predicted gene 5800 (from RefSeq NM_001034102.3) EG545047 ENSMUST00000095916.1 ENSMUST00000095916.2 Gm5800 NM_001034102 Q497L3 Q497L3_MOUSE uc007tnc.1 uc007tnc.2 uc007tnc.3 molecular_function cellular_component biological_process uc007tnc.1 uc007tnc.2 uc007tnc.3 
ENSMUST00000095922.5 Vmn2r12 ENSMUST00000095922.5 vomeronasal 2, receptor 12, transcript variant 2 (from RefSeq NM_001385229.1) ENSMUST00000095922.1 ENSMUST00000095922.2 ENSMUST00000095922.3 ENSMUST00000095922.4 L7N217 L7N217_MOUSE NM_001385229 Vmn2r12 uc009vdj.1 uc009vdj.2 uc009vdj.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vdj.1 uc009vdj.2 uc009vdj.3 
ENSMUST00000095925.5 Pnp2 ENSMUST00000095925.5 purine-nucleoside phosphorylase 2 (from RefSeq NM_001123371.2) ENSMUST00000095925.1 ENSMUST00000095925.2 ENSMUST00000095925.3 ENSMUST00000095925.4 NM_001123371 Pnp Pnp2 Q9D8C9 Q9D8C9_MOUSE uc007tmf.1 uc007tmf.2 uc007tmf.3 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Reaction=2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + guanine; Xref=Rhea:RHEA:27738, ChEBI:CHEBI:16235, ChEBI:CHEBI:17172, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.1; Evidence= Reaction=2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + hypoxanthine; Xref=Rhea:RHEA:27750, ChEBI:CHEBI:17368, ChEBI:CHEBI:28997, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.1; Evidence= Reaction=guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine; Xref=Rhea:RHEA:13233, ChEBI:CHEBI:16235, ChEBI:CHEBI:16750, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.1; Evidence= Reaction=inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine; Xref=Rhea:RHEA:27646, ChEBI:CHEBI:17368, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.1; Evidence= Purine metabolism; purine nucleoside salvage. Homotrimer. Belongs to the PNP/MTAP phosphorylase family. nucleoside binding purine nucleobase binding catalytic activity purine-nucleoside phosphorylase activity extracellular region nucleus cytoplasm cytosol nucleobase-containing compound metabolic process drug binding nucleoside metabolic process transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups phosphate ion binding uc007tmf.1 uc007tmf.2 uc007tmf.3 
ENSMUST00000095932.5 Ccnb1ip1 ENSMUST00000095932.5 cyclin B1 interacting protein 1 (from RefSeq NM_001111119.1) CIP1_MOUSE D3Z3K2 ENSMUST00000095932.1 ENSMUST00000095932.2 ENSMUST00000095932.3 ENSMUST00000095932.4 Gm288 Hei10 Mei4 NM_001111119 uc011zjw.1 uc011zjw.2 uc011zjw.3 Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non- crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with CCNB1, UBE2L3 and NF2. Nucleus Chromosome Note=Associates to the synaptonemal complex. Expressed predominantly in the testes and 17 day embryos (corresponding to prophase I in females). Weakly or not expressed in other tissues. In spermatocytes, synaptonemal complex-associated Ccnb1ip1 foci are detected by early pachynema and their number peaks during midpachynema. In late-pachytene nuclei, Ccnb1ip1 foci number descrease. At the onset of diplonema, foci are no longer detected (at protein level). Ubiquitinated; autoubiquitinated. Phosphorylated by CDK1 on serine or threonine residues (in vitro). Both male and female mice are sterile. Males do not make sperm and have much smaller testes, a characteristic of mutants with meiotic defects. Early stages of meiosis occur normally and full synapsis of homologous chromosomes (homologs) is achieved. However, crossover-specific recombination complexes do not assemble and crossing-overs fail. In spermatocytes, chromosomes fail to congress properly at the metaphase plate, leading to arrest and apoptosis before the first meiotic division. Mutant oocytes have a similar chromosomal phenotype but can undergo meiotic divisions and fertilization before arresting. During late meiotic prophase males, absence of Cdk2 and mismatch repair protein association from chromosome cores is correlated with the premature separation of bivalents at diplonema owing to lack of chiasmata. condensed nuclear chromosome synaptonemal complex blastocyst formation ubiquitin-protein transferase activity nucleus chromosome reciprocal meiotic recombination spermatid development protein ubiquitination transferase activity metal ion binding chiasma assembly meiotic cell cycle ubiquitin protein ligase activity uc011zjw.1 uc011zjw.2 uc011zjw.3 
ENSMUST00000095934.3 Krtap26-1 ENSMUST00000095934.3 keratin associated protein 26-1 (from RefSeq NM_027105.3) B9EIF2 ENSMUST00000095934.1 ENSMUST00000095934.2 KR261_MOUSE Krtap26-1 NM_027105 Q9D7N2 uc007zva.1 uc007zva.2 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). Interacts with hair keratins. Belongs to the PMG family. molecular_function cellular_component intermediate filament biological_process uc007zva.1 uc007zva.2 
ENSMUST00000095938.10 AI854703 ENSMUST00000095938.10 expressed sequence AI854703, transcript variant 3 (from RefSeq NM_001402007.1) AI854703 ENSMUST00000095938.1 ENSMUST00000095938.2 ENSMUST00000095938.3 ENSMUST00000095938.4 ENSMUST00000095938.5 ENSMUST00000095938.6 ENSMUST00000095938.7 ENSMUST00000095938.8 ENSMUST00000095938.9 NM_001402007 Q8BIN3 Q8BIN3_MOUSE uc291egd.1 uc291egd.2 Nucleus nucleic acid binding uc291egd.1 uc291egd.2 
ENSMUST00000095944.10 Zfp777 ENSMUST00000095944.10 zinc finger protein 777, transcript variant 2 (from RefSeq NM_001347139.1) ENSMUST00000095944.1 ENSMUST00000095944.2 ENSMUST00000095944.3 ENSMUST00000095944.4 ENSMUST00000095944.5 ENSMUST00000095944.6 ENSMUST00000095944.7 ENSMUST00000095944.8 ENSMUST00000095944.9 G5E8L5 G5E8L5_MOUSE NM_001347139 Zfp777 uc009btu.1 uc009btu.2 uc009btu.3 molecular_function nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc009btu.1 uc009btu.2 uc009btu.3 
ENSMUST00000095950.3 Vti1a ENSMUST00000095950.3 vesicle transport through interaction with t-SNAREs 1A, transcript variant 2 (from RefSeq NM_016862.4) ENSMUST00000095950.1 ENSMUST00000095950.2 NM_016862 O89116 Q545P9 VTI1A_MOUSE Vti1 Vti1l2 uc008hxx.1 uc008hxx.2 uc008hxx.3 uc008hxx.4 V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be concerned with increased secretion of cytokines associated with cellular senescence. Interacts with distinct SNARE complexes that contain either STX5 or STX6. Interacts with NAPA and, to a lesser extent, with NAPG. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Golgi apparatus membrane ; Single- pass type IV membrane protein Widely expressed. Belongs to the VTI1 family. Golgi membrane SNARE binding SNAP receptor activity endosome autophagosome endoplasmic reticulum membrane Golgi apparatus cytosol protein targeting to vacuole intracellular protein transport ER to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport Golgi to vacuole transport autophagy synaptic vesicle ER to Golgi transport vesicle membrane protein transport membrane integral component of membrane synaptic vesicle to endosome fusion vesicle-mediated transport clathrin-coated vesicle SNARE complex late endosome membrane retrograde transport, endosome to Golgi neuronal cell body intracellular membrane-bounded organelle neuron projection terminus vesicle fusion with Golgi apparatus perinuclear region of cytoplasm voluntary musculoskeletal movement Golgi ribbon formation uc008hxx.1 uc008hxx.2 uc008hxx.3 uc008hxx.4 
ENSMUST00000095959.2 Ptgdr ENSMUST00000095959.2 prostaglandin D receptor (from RefSeq NM_008962.4) A2RSY4 ENSMUST00000095959.1 NM_008962 P70263 PD2R_MOUSE Q8CCM3 uc007ter.1 uc007ter.2 Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3- dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557). Cell membrane ; Multi-pass membrane protein Most abundantly expressed in the ileum, followed by lung, stomach and uterus. Mutant mice show decreased susceptibility to passive cutaneous anaphylaxis associated with decreased mast cell degranulation. Belongs to the G-protein coupled receptor 1 family. prostaglandin J receptor activity G-protein coupled receptor activity prostaglandin D receptor activity plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane male sex determination sleep adenosine metabolic process cellular response to prostaglandin D stimulus adenylate cyclase-activating G-protein coupled receptor signaling pathway uc007ter.1 uc007ter.2 
ENSMUST00000095960.5 Vmn1r212 ENSMUST00000095960.5 vomeronasal 1 receptor 212 (from RefSeq NM_134241.1) ENSMUST00000095960.1 ENSMUST00000095960.2 ENSMUST00000095960.3 ENSMUST00000095960.4 NM_134241 Q8R268 Q8R268_MOUSE V1rh18 Vmn1r212 uc007ptc.1 uc007ptc.2 uc007ptc.3 Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc007ptc.1 uc007ptc.2 uc007ptc.3 
ENSMUST00000095978.5 Nutf2-ps1 ENSMUST00000095978.5 Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. (from UniProt P61971) AK012500 ENSMUST00000095978.1 ENSMUST00000095978.2 ENSMUST00000095978.3 ENSMUST00000095978.4 NTF2_MOUSE Ntf2 Nutf2 P13662 P61971 Q3TI35 uc289sjp.1 uc289sjp.2 uc289sjp.3 Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. Homodimer. Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import. Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import. Interacts with CAPG; mediates its nuclear import. Cytoplasm, cytosol Nucleus outer membrane Nucleus, nuclear pore complex Nucleus inner membrane Nucleus, nucleoplasm Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. nucleus nuclear inner membrane nuclear outer membrane nuclear pore nucleoplasm cytoplasm cytosol protein import into nucleus protein export from nucleus nucleocytoplasmic transport Ran GTPase binding protein transport membrane structural constituent of nuclear pore nuclear membrane positive regulation of protein import into nucleus identical protein binding nuclear pore central transport channel mRNA transport nuclear import signal receptor activity protein localization to nuclear pore negative regulation of vascular endothelial growth factor production uc289sjp.1 uc289sjp.2 uc289sjp.3 
ENSMUST00000095985.5 1700049E17Rik1 ENSMUST00000095985.5 RIKEN cDNA 1700049E17 gene, gene 1 (from RefSeq NM_001358038.1) 1700049E17Rik1 1700049E17Rik2 E9Q8F7 ENSMUST00000095985.1 ENSMUST00000095985.2 ENSMUST00000095985.3 ENSMUST00000095985.4 F6QVC4 F6QVC4_MOUSE NM_001358038 uc288som.1 uc288som.2 molecular_function cellular_component biological_process uc288som.1 uc288som.2 
ENSMUST00000095987.4 Tmem139 ENSMUST00000095987.4 transmembrane protein 139 (from RefSeq NM_175408.4) E9PX92 E9PX92_MOUSE ENSMUST00000095987.1 ENSMUST00000095987.2 ENSMUST00000095987.3 NM_175408 Tmem139 uc009bqp.1 uc009bqp.2 molecular_function cellular_component biological_process membrane integral component of membrane uc009bqp.1 uc009bqp.2 
ENSMUST00000095998.7 Itprip ENSMUST00000095998.7 inositol 1,4,5-triphosphate receptor interacting protein, transcript variant 3 (from RefSeq NM_001362459.2) ENSMUST00000095998.1 ENSMUST00000095998.2 ENSMUST00000095998.3 ENSMUST00000095998.4 ENSMUST00000095998.5 ENSMUST00000095998.6 IPRI_MOUSE Kiaa1754 NM_001362459 Q3TAD9 Q3TB01 Q3TNL8 Q571G7 Q6P400 uc008hvv.1 uc008hvv.2 uc008hvv.3 uc008hvv.4 Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release. Interacts with ITPR. Cell membrane ; Single-pass type I membrane protein Nucleus outer membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TNL8-1; Sequence=Displayed; Name=2; IsoId=Q3TNL8-2; Sequence=VSP_026571; Belongs to the ITPRIP family. protein kinase inhibitor activity protein binding nuclear outer membrane plasma membrane negative regulation of protein kinase activity membrane negative regulation of extrinsic apoptotic signaling pathway via death domain receptors uc008hvv.1 uc008hvv.2 uc008hvv.3 uc008hvv.4 
ENSMUST00000095999.7 Prss3l ENSMUST00000095999.7 serine protease 3 like, transcript variant 2 (from RefSeq NM_001411837.1) EG436523 ENSMUST00000095999.1 ENSMUST00000095999.2 ENSMUST00000095999.3 ENSMUST00000095999.4 ENSMUST00000095999.5 ENSMUST00000095999.6 Gm10334 Gm5771 NM_001411837 Prss3l Q792Y8 Q792Y8_MOUSE trypsinogen uc009vdt.1 uc009vdt.2 uc009vdt.3 serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009vdt.1 uc009vdt.2 uc009vdt.3 
ENSMUST00000096000.4 Sh2d4b ENSMUST00000096000.4 SH2 domain containing 4B, transcript variant 1 (from RefSeq NM_177816.5) A6X942 B2RSQ7 ENSMUST00000096000.1 ENSMUST00000096000.2 ENSMUST00000096000.3 NM_177816 Q8BQI0 SH24B_MOUSE uc007tce.1 uc007tce.2 uc007tce.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A6X942-1; Sequence=Displayed; Name=2; IsoId=A6X942-2; Sequence=VSP_029013; molecular_function cytoplasm biological_process uc007tce.1 uc007tce.2 uc007tce.3 
ENSMUST00000096003.7 Prss3 ENSMUST00000096003.7 serine protease 3 (from RefSeq NM_011645.2) ENSMUST00000096003.1 ENSMUST00000096003.2 ENSMUST00000096003.3 ENSMUST00000096003.4 ENSMUST00000096003.5 ENSMUST00000096003.6 NM_011645 Prss3 Q792Z0 Q792Z0_MOUSE Tcrb-V20 trypsinogen uc009bov.1 uc009bov.2 uc009bov.3 uc009bov.4 serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009bov.1 uc009bov.2 uc009bov.3 uc009bov.4 
ENSMUST00000096014.5 Atp5mk ENSMUST00000096014.5 ATP synthase membrane subunit k (from RefSeq NM_023211.5) ATPMK_MOUSE Atp5md Atp5mk Dapit ENSMUST00000096014.1 ENSMUST00000096014.2 ENSMUST00000096014.3 ENSMUST00000096014.4 NM_023211 Q78IK2 Q9ER48 Usmg5 uc008huo.1 uc008huo.2 uc008huo.3 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. ATP5MK is a minor subunit of the mitochondrial membrane ATP synthase required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria. Component of the ATP synthase complex/complex V which is composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). The ATP synthase complex/complex V exists as a monomeric and a dimeric supercomplex that helps shape mitochondrial cristae to optimize proton flow (By similarity). Mitochondrion membrane ; Single-pass membrane protein molecular_function mitochondrion mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex biological_process membrane integral component of membrane mitochondrial membrane uc008huo.1 uc008huo.2 uc008huo.3 
ENSMUST00000096030.7 Klrg2 ENSMUST00000096030.7 killer cell lectin-like receptor subfamily G, member 2 (from RefSeq NM_001033171.2) ENSMUST00000096030.1 ENSMUST00000096030.2 ENSMUST00000096030.3 ENSMUST00000096030.4 ENSMUST00000096030.5 ENSMUST00000096030.6 G5E8L6 G5E8L6_MOUSE Klrg2 NM_001033171 uc009bkv.1 uc009bkv.2 uc009bkv.3 membrane integral component of membrane carbohydrate binding uc009bkv.1 uc009bkv.2 uc009bkv.3 
ENSMUST00000096038.4 3425401B19Rik ENSMUST00000096038.4 RIKEN cDNA 3425401B19 gene, transcript variant 7 (from RefSeq NM_001419654.1) CEFIP CEFIP_MOUSE D3Z1D3 ENSMUST00000096038.1 ENSMUST00000096038.2 ENSMUST00000096038.3 NM_001419654 uc007szg.1 uc007szg.2 uc007szg.3 Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Interacts with FHL2. Cytoplasm, myofibril, sarcomere, Z line Expressed in the heart and skeletal muscle (at protein level). molecular_function cytoplasm Z disc positive regulation of calcineurin-NFAT signaling cascade uc007szg.1 uc007szg.2 uc007szg.3 
ENSMUST00000096040.11 Svopl ENSMUST00000096040.11 SV2 related protein homolog (rat)-like (from RefSeq NM_177200.4) ENSMUST00000096040.1 ENSMUST00000096040.10 ENSMUST00000096040.2 ENSMUST00000096040.3 ENSMUST00000096040.4 ENSMUST00000096040.5 ENSMUST00000096040.6 ENSMUST00000096040.7 ENSMUST00000096040.8 ENSMUST00000096040.9 NM_177200 Q6PDF3 Q8BM44 SVOPL_MOUSE uc009bjm.1 uc009bjm.2 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PDF3-1; Sequence=Displayed; Name=2; IsoId=Q6PDF3-2; Sequence=VSP_026653, VSP_026654; Belongs to the major facilitator superfamily. integral component of plasma membrane membrane integral component of membrane transmembrane transport uc009bjm.1 uc009bjm.2 
ENSMUST00000096045.9 Dppa4 ENSMUST00000096045.9 developmental pluripotency associated 4, transcript variant 1 (from RefSeq NM_028610.2) DPPA4_MOUSE ENSMUST00000096045.1 ENSMUST00000096045.2 ENSMUST00000096045.3 ENSMUST00000096045.4 ENSMUST00000096045.5 ENSMUST00000096045.6 ENSMUST00000096045.7 ENSMUST00000096045.8 NM_028610 Q6P228 Q810Y6 Q8CCG4 uc007zjl.1 uc007zjl.2 uc007zjl.3 May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic stem (ES) cells into a primitive ectoderm lineage. Interacts with DPPA2 (PubMed:21896782). Interacts with PCGF1 (By similarity). Nucleus te=Associated with transcriptionally active chromatin. Expressed in pluripotent embryonic cells, but not in differentiated somatic tissues. Expressed in 4-cell embryo, morula and blastocyst. At 7.5 dpc, detected in the epiblast. At 10.0 dpc, expressed in the primordial germ cells and at 12.0 dpc in the embryonic gonads. At 14.5 dpc, expression is restricted to testis. 6 days after birth, still detected in primitive type A spermatogonia. Expressed in undifferentiated embryonic stem cells, but expression decreases upon differentiation (at protein level). The mortality of mutant animals is increased at birth and most die within 3 days. The few surviving neonates show growth retardation, but they catch up with wild-type mice by 20 weeks of age. chromatin binding nucleus multicellular organism development lung-associated mesenchyme development uc007zjl.1 uc007zjl.2 uc007zjl.3 
ENSMUST00000096053.6 Slf2 ENSMUST00000096053.6 SMC5-SMC6 complex localization factor 2, transcript variant 4 (from RefSeq NR_175949.1) E9Q839 E9Q839_MOUSE ENSMUST00000096053.1 ENSMUST00000096053.2 ENSMUST00000096053.3 ENSMUST00000096053.4 ENSMUST00000096053.5 Fam178a NR_175949 Slf2 uc008hqb.1 uc008hqb.2 uc008hqb.3 uc008hqb.4 Belongs to the FAM178 family. chromatin nucleus cellular response to DNA damage stimulus positive regulation of protein complex assembly ubiquitin protein ligase binding positive regulation of maintenance of mitotic sister chromatid cohesion site of double-strand break intracellular membrane-bounded organelle macromolecular complex binding protein localization to site of double-strand break positive regulation of double-strand break repair uc008hqb.1 uc008hqb.2 uc008hqb.3 uc008hqb.4 
ENSMUST00000096057.5 Tagln3 ENSMUST00000096057.5 transgelin 3 (from RefSeq NM_019754.3) ENSMUST00000096057.1 ENSMUST00000096057.2 ENSMUST00000096057.3 ENSMUST00000096057.4 NM_019754 Np25 Q9R1Q8 TAGL3_MOUSE uc007ziw.1 uc007ziw.2 uc007ziw.3 Belongs to the calponin family. negative regulation of transcription from RNA polymerase II promoter molecular_function nucleus myelin sheath uc007ziw.1 uc007ziw.2 uc007ziw.3 
ENSMUST00000096065.6 Tigit ENSMUST00000096065.6 T cell immunoreceptor with Ig and ITIM domains (from RefSeq NM_001146325.1) A0A0B4J1G6 A0A0B4J1G6_MOUSE ENSMUST00000096065.1 ENSMUST00000096065.2 ENSMUST00000096065.3 ENSMUST00000096065.4 ENSMUST00000096065.5 NM_001146325 Tigit uc012afs.1 uc012afs.2 uc012afs.3 receptor binding cell surface membrane integral component of membrane negative regulation of interleukin-12 production positive regulation of interleukin-10 production identical protein binding negative regulation of T cell activation uc012afs.1 uc012afs.2 uc012afs.3 
ENSMUST00000096066.5 Cpa2 ENSMUST00000096066.5 carboxypeptidase A2, pancreatic (from RefSeq NM_001024698.3) CBPA2_MOUSE ENSMUST00000096066.1 ENSMUST00000096066.2 ENSMUST00000096066.3 ENSMUST00000096066.4 NM_001024698 Q504N0 uc009bfn.1 uc009bfn.2 uc009bfn.3 This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is expressed by the pancreatic exocrine cells which secrete the enzyme during digestion. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Reaction=Similar to that of carboxypeptidase A (EC 3.4.17.1), but with a preference for bulkier C-terminal residues.; EC=3.4.17.15; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted Belongs to the peptidase M14 family. carboxypeptidase activity metallocarboxypeptidase activity extracellular region extracellular space proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding uc009bfn.1 uc009bfn.2 uc009bfn.3 
ENSMUST00000096069.5 Tasor2 ENSMUST00000096069.5 transcription activation suppressor family member 2, transcript variant 1 (from RefSeq NM_134063.3) ENSMUST00000096069.1 ENSMUST00000096069.2 ENSMUST00000096069.3 ENSMUST00000096069.4 Fam208b Kiaa2006 NM_134063 O35330 Pap20 Q0P5P9 Q3UUS0 Q5DTT3 Q5U5L9 Q6DI89 Q6ZQM5 Q91W76 TASO2_MOUSE uc007pix.1 uc007pix.2 Belongs to the TASOR family. Sequence=AAB71190.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH16423.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH75685.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC87659.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD90477.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function nucleus nucleoplasm cytosol biological_process uc007pix.1 uc007pix.2 
ENSMUST00000096089.3 Cstdc5 ENSMUST00000096089.3 cystatin domain containing 5 (from RefSeq NM_001082546.1) BC100530 Cstdc5 ENSMUST00000096089.1 ENSMUST00000096089.2 NM_001082546 Q497J0 Q497J0_MOUSE Stfa3 uc007zcm.1 uc007zcm.2 uc007zcm.3 Belongs to the cystatin family. endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity cytosol negative regulation of endopeptidase activity uc007zcm.1 uc007zcm.2 uc007zcm.3 
ENSMUST00000096090.3 Csta1 ENSMUST00000096090.3 cystatin A1 (from RefSeq NM_001033239.3) CYTA_MOUSE Csta ENSMUST00000096090.1 ENSMUST00000096090.2 NM_001033239 P56567 Q3UV05 uc007zcf.1 uc007zcf.2 uc007zcf.3 This is an intracellular thiol proteinase inhibitor. Cytoplasm Belongs to the cystatin family. cornified envelope protease binding endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular space nucleus cytoplasm cytosol negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc007zcf.1 uc007zcf.2 uc007zcf.3 
ENSMUST00000096109.11 Pigx ENSMUST00000096109.11 phosphatidylinositol glycan anchor biosynthesis, class X, transcript variant 1 (from RefSeq NM_024464.3) ENSMUST00000096109.1 ENSMUST00000096109.10 ENSMUST00000096109.2 ENSMUST00000096109.3 ENSMUST00000096109.4 ENSMUST00000096109.5 ENSMUST00000096109.6 ENSMUST00000096109.7 ENSMUST00000096109.8 ENSMUST00000096109.9 NM_024464 PIGX_MOUSE Q99LV7 uc007yye.1 uc007yye.2 uc007yye.3 uc007yye.4 uc007yye.5 This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Essential component of glycosylphosphatidylinositol- mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity). Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Interacts with PIGM. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99LV7-1; Sequence=Displayed; Name=2; IsoId=Q99LV7-2; Sequence=VSP_019843; N-glycosylated. Belongs to the PIGX family. Sequence=BAC25223.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence=; molecular_function cellular_component endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process membrane integral component of membrane uc007yye.1 uc007yye.2 uc007yye.3 uc007yye.4 uc007yye.5 
ENSMUST00000096114.13 Rnls ENSMUST00000096114.13 renalase, FAD-dependent amine oxidase, transcript variant 1, non-coding (from RefSeq NR_160911.1) A0A0R4J156 A0A0R4J156_MOUSE ENSMUST00000096114.1 ENSMUST00000096114.10 ENSMUST00000096114.11 ENSMUST00000096114.12 ENSMUST00000096114.2 ENSMUST00000096114.3 ENSMUST00000096114.4 ENSMUST00000096114.5 ENSMUST00000096114.6 ENSMUST00000096114.7 ENSMUST00000096114.8 ENSMUST00000096114.9 NR_160911 Rnls uc008hft.1 uc008hft.2 uc008hft.3 uc008hft.4 uc008hft.5 uc008hft.6 oxidoreductase activity oxidoreductase activity, acting on NAD(P)H oxidation-reduction process uc008hft.1 uc008hft.2 uc008hft.3 uc008hft.4 uc008hft.5 uc008hft.6 
ENSMUST00000096121.12 Gm5458 ENSMUST00000096121.12 predicted gene 5458, transcript variant 2 (from RefSeq NM_001403651.1) ENSMUST00000096121.1 ENSMUST00000096121.10 ENSMUST00000096121.11 ENSMUST00000096121.2 ENSMUST00000096121.3 ENSMUST00000096121.4 ENSMUST00000096121.5 ENSMUST00000096121.6 ENSMUST00000096121.7 ENSMUST00000096121.8 ENSMUST00000096121.9 Gm5458 L7N219 L7N219_MOUSE NM_001403651 uc011zgi.1 uc011zgi.2 uc011zgi.3 molecular_function cellular_component biological_process uc011zgi.1 uc011zgi.2 uc011zgi.3 
ENSMUST00000096145.5 Gm10337 ENSMUST00000096145.5 Gm10337 (from geneSymbol) ENSMUST00000096145.1 ENSMUST00000096145.2 ENSMUST00000096145.3 ENSMUST00000096145.4 F7DEP7 F7DEP7_MOUSE Gm10337 uc289buj.1 uc289buj.2 molecular_function cellular_component biological_process uc289buj.1 uc289buj.2 
ENSMUST00000096148.11 Gm10338 ENSMUST00000096148.11 Gm10338 (from geneSymbol) ENSMUST00000096148.1 ENSMUST00000096148.10 ENSMUST00000096148.2 ENSMUST00000096148.3 ENSMUST00000096148.4 ENSMUST00000096148.5 ENSMUST00000096148.6 ENSMUST00000096148.7 ENSMUST00000096148.8 ENSMUST00000096148.9 Gm10338 K7N692 K7N692_MOUSE uc288qqq.1 uc288qqq.2 molecular_function cellular_component biological_process uc288qqq.1 uc288qqq.2 
ENSMUST00000096164.6 Entrep1 ENSMUST00000096164.6 endosomal transmembrane epsin interactor 1 (from RefSeq NM_001114174.1) E9QP68 ENSMUST00000096164.1 ENSMUST00000096164.2 ENSMUST00000096164.3 ENSMUST00000096164.4 ENSMUST00000096164.5 EREP1_MOUSE Entrep1 Fam189a2 Gm967 NM_001114174 Q4FZH1 uc008hak.1 uc008hak.2 uc008hak.3 uc008hak.4 uc008hak.5 Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway. Interacts with ITCH; enhances the ubiquitination of CXCR4 by ITCH and the subsequent endocytosis and desensitization of the receptor. Interacts with EPN1. Early endosome membrane ; Single-pass type I membrane protein Late endosome membrane ; Single-pass type I membrane protein Recycling endosome membrane ; Single-pass type I membrane protein Cell membrane ; Single-pass type I membrane protein Note=Enriched in endosomes compared to the cell membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q4FZH1-1; Sequence=Displayed; Name=2; IsoId=Q4FZH1-2; Sequence=VSP_061675; The cytoplasmic PPxY motifs mediate interaction with the WW domains of ITCH. [Isoform 1]: Gene prediction based on similarity to the human ortholog. [Isoform 2]: Gene prediction based on EST data. Belongs to the ENTREP family. Sequence=AAH99492.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component biological_process uc008hak.1 uc008hak.2 uc008hak.3 uc008hak.4 uc008hak.5 
ENSMUST00000096168.6 Gm10408 ENSMUST00000096168.6 predicted gene 10408 (from RefSeq NM_001256501.1) ENSMUST00000096168.1 ENSMUST00000096168.2 ENSMUST00000096168.3 ENSMUST00000096168.4 ENSMUST00000096168.5 Gm10408 Gm3043 K7N693 K7N693_MOUSE NM_001256501 uc029sec.1 uc029sec.2 uc029sec.3 uc029sec.4 molecular_function cellular_component biological_process uc029sec.1 uc029sec.2 uc029sec.3 uc029sec.4 
ENSMUST00000096170.5 Gm5622 ENSMUST00000096170.5 predicted gene 5622 (from RefSeq NM_001013816.1) EG434459 ENSMUST00000096170.1 ENSMUST00000096170.2 ENSMUST00000096170.3 ENSMUST00000096170.4 Gm5622 NM_001013816 Q810Q0 Q810Q0_MOUSE uc007tnb.1 uc007tnb.2 molecular_function cellular_component biological_process uc007tnb.1 uc007tnb.2 
ENSMUST00000096184.5 Gm5796 ENSMUST00000096184.5 predicted gene 5796 (from RefSeq NM_001029930.2) E9Q7M8 E9Q7M8_MOUSE ENSMUST00000096184.1 ENSMUST00000096184.2 ENSMUST00000096184.3 ENSMUST00000096184.4 Gm5796 NM_001029930 uc007sbl.1 uc007sbl.2 uc007sbl.3 molecular_function cellular_component biological_process uc007sbl.1 uc007sbl.2 uc007sbl.3 
ENSMUST00000096197.11 Vwa5b2 ENSMUST00000096197.11 von Willebrand factor A domain containing 5B2, transcript variant 4 (from RefSeq NM_001384105.1) ENSMUST00000096197.1 ENSMUST00000096197.10 ENSMUST00000096197.2 ENSMUST00000096197.3 ENSMUST00000096197.4 ENSMUST00000096197.5 ENSMUST00000096197.6 ENSMUST00000096197.7 ENSMUST00000096197.8 ENSMUST00000096197.9 NM_001384105 Q2TB01 Q3UR50 Q80WS8 Q8BR57 VW5B2_MOUSE uc012acu.1 uc012acu.2 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UR50-1; Sequence=Displayed; Name=2; IsoId=Q3UR50-2; Sequence=VSP_034144, VSP_034145; Name=3; IsoId=Q3UR50-5; Sequence=VSP_034141, VSP_034146; Sequence=AAI10636.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=AAI25017.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; molecular_function cellular_component biological_process uc012acu.1 uc012acu.2 
ENSMUST00000096200.6 Tmprss12 ENSMUST00000096200.6 transmembrane (C-terminal) protease, serine 12, transcript variant 1 (from RefSeq NM_183109.4) ENSMUST00000096200.1 ENSMUST00000096200.2 ENSMUST00000096200.3 ENSMUST00000096200.4 ENSMUST00000096200.5 NM_183109 Q3V0Q7 TMPSC_MOUSE Tmprss12 uc007xqu.1 uc007xqu.2 uc007xqu.3 Required for male fertility (PubMed:32529245, PubMed:35547804). Plays a critical role in sperm capacitation and acrosome reactions during fertilization, and also plays a role in the regulation of proteins involved in spermatogenesis (PubMed:35547804). Regulates protein pathways that promote chromosomal synapsis formation, double-strand break repair, formation of the inner mitochondrial membrane cristae and apoptosis in developing sperm (PubMed:35547804). Required for normal sperm motility and binding to the zona pellucida, potentially via a role in ADAM3 protein maturation (PubMed:32529245). Cell membrane ; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle, acrosome te=Expression in the acrosome decreases after acrosome reaction. Exclusively expressed in the testis, from spermatocytes to elongated spermatids (at protein level). Initially expressed in the testis at 10 days of age, expression increases until 2 weeks of age whereafter protein abundance remains consistent (at protein level). Male mice are infertile (PubMed:32529245, PubMed:35547804). Decrease in sperm count and sperm motility, as a result of decreased numbers of pachytene spermatocytes, diplotene spermatocytes, round spermatids and elongated spermatids (PubMed:35547804). Increase in the rate of apoptosis among spermatocytes accompanied by abnormal chromosomal synapsis and failure of double-strand break repair during meiosis in the testis (PubMed:35547804). Increase in the number of sperm with abnormal mitochondria that show blurred or absent inner mitochondrial membrane cristae with decreased ATP content and oxygen consumption, together with a decrease in expression of key markers of oxidative phosphorylation such as Mtatp6/MTATP and Cstb/MTCYB (PubMed:35547804). Ejaculated sperm fail to migrate from the uterus to the oviduct due to significantly reduced sperm motility (PubMed:32529245). Spermatozoa binding to the zona pellucida is significantly reduced in vitro, resulting in a loss of fertilization, this can be rescued via weakening of the zona pellucida (PubMed:32529245). Decrease in mature ADAM3 protein in spermatozoa but normal levels are seen in testicular germ cells (PubMed:32529245). In the testis there is a decrease in abundance of proteins involved in meiosis, apoptosis, mitochondrial function and cell adhesion such as Klc3, Rad51, Bccip, Pgam2 and Mgst1 (PubMed:35547804). Belongs to the peptidase S1 family. serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc007xqu.1 uc007xqu.2 uc007xqu.3 
ENSMUST00000096201.4 Or5b117 ENSMUST00000096201.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQQ9) ENSMUST00000096201.1 ENSMUST00000096201.2 ENSMUST00000096201.3 Olfr1472 Olfr1477 Or5b117 Q7TQQ9 Q7TQQ9_MOUSE uc289rfc.1 uc289rfc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rfc.1 uc289rfc.2 
ENSMUST00000096224.6 Adcy6 ENSMUST00000096224.6 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (from UniProt F8VQ52) AK147516 Adcy6 ENSMUST00000096224.1 ENSMUST00000096224.2 ENSMUST00000096224.3 ENSMUST00000096224.4 ENSMUST00000096224.5 F8VQ52 F8VQ52_MOUSE uc007xna.1 uc007xna.2 uc007xna.3 uc007xna.4 uc007xna.5 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro). ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding adenylate cyclase activity protein kinase C binding ATP binding plasma membrane cAMP biosynthetic process adenylate cyclase-activating G-protein coupled receptor signaling pathway dopamine receptor signaling pathway cyclic nucleotide biosynthetic process membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity intracellular signal transduction metal ion binding cellular response to prostaglandin E stimulus cellular response to catecholamine stimulus regulation of blood vessel diameter cellular response to forskolin uc007xna.1 uc007xna.2 uc007xna.3 uc007xna.4 uc007xna.5 
ENSMUST00000096229.11 Dnm1l ENSMUST00000096229.11 dynamin 1-like, transcript variant 24 (from RefSeq NR_175921.1) ENSMUST00000096229.1 ENSMUST00000096229.10 ENSMUST00000096229.2 ENSMUST00000096229.3 ENSMUST00000096229.4 ENSMUST00000096229.5 ENSMUST00000096229.6 ENSMUST00000096229.7 ENSMUST00000096229.8 ENSMUST00000096229.9 NR_175921 uc007yil.1 uc007yil.2 uc007yil.3 uc007yil.4 uc007yil.1 uc007yil.2 uc007yil.3 uc007yil.4 
ENSMUST00000096232.6 Cebpd ENSMUST00000096232.6 CCAAT/enhancer binding protein delta (from RefSeq NM_007679.4) CEBPD_MOUSE Crp3 ENSMUST00000096232.1 ENSMUST00000096232.2 ENSMUST00000096232.3 ENSMUST00000096232.4 ENSMUST00000096232.5 NM_007679 Q00322 Q3U937 Q8BW92 uc007yhx.1 uc007yhx.2 uc007yhx.3 Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:7594592, PubMed:19641492). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity). Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPE (PubMed:1884998). Directly interacts with SPI1/PU.1; this interaction does not affect DNA-binding properties of each partner (PubMed:7594592). Interacts with PRDM16 (PubMed:19641492). Nucleus Belongs to the bZIP family. C/EBP subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding hematopoietic progenitor cell differentiation DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein homodimerization activity sequence-specific DNA binding transcription regulatory region DNA binding fat cell differentiation positive regulation of osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity inner ear development uc007yhx.1 uc007yhx.2 uc007yhx.3 
ENSMUST00000096239.7 Tut1 ENSMUST00000096239.7 terminal uridylyl transferase 1, U6 snRNA-specific (from RefSeq NM_197993.4) ENSMUST00000096239.1 ENSMUST00000096239.2 ENSMUST00000096239.3 ENSMUST00000096239.4 ENSMUST00000096239.5 ENSMUST00000096239.6 NM_197993 Q3UUH3 Q8R3F9 Rbm21 STPAP_MOUSE uc008goh.1 uc008goh.2 uc008goh.3 uc008goh.4 Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation. Reaction=RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide; Xref=Rhea:RHEA:14785, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17348, ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:140395, ChEBI:CHEBI:173116; EC=2.7.7.52; Evidence=; Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, ChEBI:CHEBI:173115; EC=2.7.7.19; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 divalent cation per subunit. ; Adenylyltransferase activity is specifically phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Associates with the cleavage and polyadenylation specificity factor (CPSF) complex. Interacts with CPSF1 and CPSF3; the interaction is direct. Interacts with PIP5K1A. Nucleus, nucleolus Nucleus speckle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R3F9-1; Sequence=Displayed; Name=2; IsoId=Q8R3F9-2; Sequence=VSP_021201, VSP_021202; The zinc-finger domain is required for terminal uridylyltransferase activity. Together with the RRM domain, binds the 5'-area of U6 snRNA. The RRM domain is required for terminal uridylyltransferase activity. Together with the zinc-finger domain, binds the 5'-area of U6 snRNA. The proline-rich region is dispensable for terminal uridylyltransferase activity. Phosphorylated by CK1 in the proline-rich (Pro-rich) region. Belongs to the DNA polymerase type-B-like family. nucleotide binding nucleic acid binding RNA binding mRNA 3'-UTR binding polynucleotide adenylyltransferase activity ATP binding nucleus nucleolus cytosol mRNA polyadenylation mRNA processing zinc ion binding snRNA processing nuclear speck transferase activity nucleotidyltransferase activity enzyme binding metal ion binding RNA uridylyltransferase activity pre-mRNA cleavage required for polyadenylation mRNA cleavage and polyadenylation specificity factor complex histone mRNA catabolic process uc008goh.1 uc008goh.2 uc008goh.3 uc008goh.4 
ENSMUST00000096240.3 Mta2 ENSMUST00000096240.3 metastasis-associated gene family, member 2, transcript variant 1 (from RefSeq NM_011842.4) ENSMUST00000096240.1 ENSMUST00000096240.2 MTA2_MOUSE Mta1l1 NM_011842 Q3TVT8 Q9R190 uc008gof.1 uc008gof.2 uc008gof.3 May function as a transcriptional coregulator (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:10444591, PubMed:27806305). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:27806305). Interacts with CHD3 (By similarity). Interacts with CHD4 (By similarity). Interacts with GATAD2A (By similarity). Interacts with HDAC7 (PubMed:10984530). Interacts with MBD3 (PubMed:12124384). Interacts with p53/TP53 (By similarity). Interacts with MINT (By similarity). Interacts with PIMREG (By similarity). Interacts with NACC2 (By similarity). Interacts with ERCC6 (By similarity). Interacts with PWWP2B (PubMed:34180153). Q9R190; Q61539: Esrrb; NbExp=3; IntAct=EBI-904134, EBI-2312731; Q9R190; O09106: Hdac1; NbExp=7; IntAct=EBI-904134, EBI-301912; Q9R190; P70288: Hdac2; NbExp=7; IntAct=EBI-904134, EBI-302251; Q9R190; P12813: Nr4a1; NbExp=2; IntAct=EBI-904134, EBI-10896863; Q9R190; P20263: Pou5f1; NbExp=6; IntAct=EBI-904134, EBI-1606219; Q9R190; Q8BX22: Sall4; NbExp=3; IntAct=EBI-904134, EBI-2312582; Q9R190; Q8VI24: Satb2; NbExp=2; IntAct=EBI-904134, EBI-5737999; Nucleus histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription factor binding RNA polymerase II repressing transcription factor binding DNA binding chromatin binding transcription cofactor activity transcription coactivator activity transcription corepressor activity histone deacetylase activity protein binding nucleus nucleoplasm transcription factor complex DNA methylation DNA packaging chromatin remodeling regulation of transcription, DNA-templated zinc ion binding regulation of fibroblast migration histone deacetylation NuRD complex histone deacetylase binding sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding uc008gof.1 uc008gof.2 uc008gof.3 
ENSMUST00000096242.5 Rom1 ENSMUST00000096242.5 rod outer segment membrane protein 1 (from RefSeq NM_009073.4) ENSMUST00000096242.1 ENSMUST00000096242.2 ENSMUST00000096242.3 ENSMUST00000096242.4 NM_009073 P32958 ROM1_MOUSE Rom-1 uc008goc.1 uc008goc.2 uc008goc.3 uc008goc.4 Plays a role in rod outer segment (ROS) morphogenesis (PubMed:10802659). May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (By similarity). Plays a role in the organization of the ROS and maintenance of ROS disk diameter (PubMed:10802659). Involved in the maintenance of the retina outer nuclear layer (PubMed:10802659). Homodimer; disulfide-linked (By similarity). Forms a homotetramer (By similarity). Forms a heterotetramer with PRPH2 (PubMed:26406599, PubMed:29961824). Homotetramer and heterotetramer core complexes go on to form higher order complexes by formation of intermolecular disulfide bonds (By similarity). Interacts with STX3 isoform 3B (PubMed:26406599). Interacts with SNAP25 (PubMed:26406599). Photoreceptor inner segment membrane ; Multi-pass membrane protein Photoreceptor outer segment membrane ; Multi-pass membrane protein Expressed in the retina (at protein level). Knockout mice are viable, fertile and grossly phenotypically normal (PubMed:10802659). 50% reduction in maximal rod photoreceptor response at 9 months of age (PubMed:10802659). Progressive thinning of the retinal outer nuclear layer becomes evident at 1 month of age (PubMed:10802659). Evidence of rod photoreceptor degeneration, shortened rod outer segment (ROS) length, increased ROS disk diameter, and progressive disorganization of the ROS at 1 month of age, leading to near-complete loss of organization by 2 months of age, however organization returns to near normal levels by 4 months of age (PubMed:10802659). Rod photoreceptors progressively die by apoptosis (PubMed:10802659). Knockout does not affect localization of Prph2 or Abca4 to ROS disk rims (PubMed:10802659). Belongs to the PRPH2/ROM1 family. photoreceptor outer segment molecular_function integral component of plasma membrane cell adhesion visual perception regulation of gene expression membrane integral component of membrane photoreceptor outer segment membrane retina morphogenesis in camera-type eye camera-type eye photoreceptor cell differentiation retina vasculature development in camera-type eye uc008goc.1 uc008goc.2 uc008goc.3 uc008goc.4 
ENSMUST00000096243.7 B3gat3 ENSMUST00000096243.7 beta-1,3-glucuronyltransferase 3 (from RefSeq NM_024256.2) B3GA3_MOUSE ENSMUST00000096243.1 ENSMUST00000096243.2 ENSMUST00000096243.3 ENSMUST00000096243.4 ENSMUST00000096243.5 ENSMUST00000096243.6 NM_024256 P58158 uc008gob.1 uc008gob.2 uc008gob.3 uc008gob.4 Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation. Reaction=3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D- xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl- [protein] + H(+) + UDP; Xref=Rhea:RHEA:24168, Rhea:RHEA-COMP:12571, Rhea:RHEA-COMP:12573, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132090, ChEBI:CHEBI:132093; EC=2.4.1.135; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Homodimer; disulfide-linked. Interacts with PXYLP1; the interaction increases the 2-phosphoxylose phosphatase activity of PXYLP1 during completion of linkage region formation in a B3GAT3- mediated manner. Golgi apparatus membrane ; Single-pass type II membrane protein Golgi apparatus, cis-Golgi network Expressed in heart, aorta, bone, and also in osteoblasts. N-glycosylated. Belongs to the glycosyltransferase 43 family. Golgi membrane Golgi apparatus cis-Golgi network glycosaminoglycan biosynthetic process protein glycosylation heparan sulfate proteoglycan biosynthetic process galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity positive regulation of catalytic activity regulation of phosphoprotein phosphatase activity metal ion binding chondroitin sulfate proteoglycan biosynthetic process dermatan sulfate proteoglycan biosynthetic process protein phosphatase activator activity positive regulation of intracellular protein transport uc008gob.1 uc008gob.2 uc008gob.3 uc008gob.4 
ENSMUST00000096246.5 Ganab ENSMUST00000096246.5 alpha glucosidase 2 alpha neutral subunit, transcript variant 1 (from RefSeq NM_008060.3) ENSMUST00000096246.1 ENSMUST00000096246.2 ENSMUST00000096246.3 ENSMUST00000096246.4 G2an GANAB_MOUSE Ganab Kiaa0088 NM_008060 O08794 Q149A6 Q80U81 Q8BHN3 Q9CS53 uc008gnw.1 uc008gnw.2 uc008gnw.3 uc008gnw.4 uc008gnw.5 Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:27462106). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:28375157). Reaction=H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man- (1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)- [alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D- Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl- [protein] = beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man- (1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)- [alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D- Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl- [protein] (N-glucan mannose isomer 9A1,2,3B1,2,3); Xref=Rhea:RHEA:56000, Rhea:RHEA-COMP:14356, Rhea:RHEA-COMP:14357, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903, ChEBI:CHEBI:59080, ChEBI:CHEBI:139493; EC=3.2.1.207; Evidence=; Reaction=H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man- (1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)- alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D- Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L- asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)- alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D- Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man- (1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc)-L-asparaginyl-[protein]; Xref=Rhea:RHEA:55996, Rhea:RHEA-COMP:14355, Rhea:RHEA-COMP:14357, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903, ChEBI:CHEBI:59080, ChEBI:CHEBI:59082; EC=3.2.1.207; Evidence=; pH dependence: Optimum pH is 6.5 - 7.; Glycan metabolism; N-glycan metabolism. Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH) (PubMed:9148925, PubMed:10921916, PubMed:27462106). Binds glycosylated PTPRC (PubMed:9148925, PubMed:10921916). Endoplasmic reticulum Golgi apparatus Melanosome Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BHN3-1; Sequence=Displayed; Name=2; IsoId=Q8BHN3-2; Sequence=VSP_010676; Name=3; IsoId=Q8BHN3-3; Sequence=VSP_010675; [Isoform 3]: May be due to an intron retention. Belongs to the glycosyl hydrolase 31 family. Sequence=BAC65483.1; Type=Erroneous initiation; Evidence=; catalytic activity hydrolase activity, hydrolyzing O-glycosyl compounds protein binding endoplasmic reticulum Golgi apparatus carbohydrate metabolic process N-glycan processing metabolic process glucosidase activity hydrolase activity hydrolase activity, acting on glycosyl bonds glucosidase II complex carbohydrate binding glucan 1,3-alpha-glucosidase activity melanosome intracellular membrane-bounded organelle alpha-glucosidase activity uc008gnw.1 uc008gnw.2 uc008gnw.3 uc008gnw.4 uc008gnw.5 
ENSMUST00000096249.7 Ints5 ENSMUST00000096249.7 integrator complex subunit 5 (from RefSeq NM_176843.3) ENSMUST00000096249.1 ENSMUST00000096249.2 ENSMUST00000096249.3 ENSMUST00000096249.4 ENSMUST00000096249.5 ENSMUST00000096249.6 INT5_MOUSE NM_176843 Q3TM44 Q8CHT3 uc008gnu.1 uc008gnu.2 uc008gnu.3 uc008gnu.4 Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Nucleus membrane ; Multi-pass membrane protein Nucleus Cytoplasm Belongs to the Integrator subunit 5 family. molecular_function nucleus cytoplasm membrane integral component of membrane snRNA processing nuclear membrane integrator complex snRNA 3'-end processing uc008gnu.1 uc008gnu.2 uc008gnu.3 uc008gnu.4 
ENSMUST00000096250.5 Arid2 ENSMUST00000096250.5 AT-rich interaction domain 2 (from RefSeq NM_175251.4) ARID2_MOUSE Arid2 Baf200 E9Q7E2 ENSMUST00000096250.1 ENSMUST00000096250.2 ENSMUST00000096250.3 ENSMUST00000096250.4 NM_175251 uc007xkd.1 uc007xkd.2 uc007xkd.3 uc007xkd.4 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin. Interacts with SRF. Forms complexes with SRF and SRF cofactors MYOCD, NKX2-5 and SRFBP1. Nucleus Highly expressed in testis, expressed in heart, liver and kidney. Belongs to the RFX family. heart morphogenesis nucleic acid binding DNA binding nucleus nucleoplasm transcription factor complex plasma membrane chromatin organization nucleosome disassembly regulation of transcription, DNA-templated transcription factor binding negative regulation of cell proliferation negative regulation of cell migration homeostatic process positive regulation of transcription from RNA polymerase II promoter metal ion binding embryonic organ development cardiac muscle cell proliferation coronary artery morphogenesis cardiovascular system development uc007xkd.1 uc007xkd.2 uc007xkd.3 uc007xkd.4 
ENSMUST00000096251.10 1810009A15Rik ENSMUST00000096251.10 RIKEN cDNA 1810009A15 gene, transcript variant 1 (from RefSeq NM_025463.3) CK098_MOUSE ENSMUST00000096251.1 ENSMUST00000096251.2 ENSMUST00000096251.3 ENSMUST00000096251.4 ENSMUST00000096251.5 ENSMUST00000096251.6 ENSMUST00000096251.7 ENSMUST00000096251.8 ENSMUST00000096251.9 NM_025463 Q9D937 uc008gnt.1 uc008gnt.2 uc008gnt.3 uc008gnt.4 This gene shares three exons in common with another gene, LBH domain containing 1 (GeneID:102308570), but the encoded protein uses a reading frame that is different from that of the LBH domain containing 1 gene. [provided by RefSeq, Nov 2017]. molecular_function cellular_component biological_process uc008gnt.1 uc008gnt.2 uc008gnt.3 uc008gnt.4 
ENSMUST00000096253.7 Uqcc3 ENSMUST00000096253.7 ubiquinol-cytochrome c reductase complex assembly factor 3 (from RefSeq NM_001160356.1) ENSMUST00000096253.1 ENSMUST00000096253.2 ENSMUST00000096253.3 ENSMUST00000096253.4 ENSMUST00000096253.5 ENSMUST00000096253.6 NM_001160356 Q8K2T4 UQCC3_MOUSE Uqcc3 uc008gnr.1 uc008gnr.2 uc008gnr.3 uc008gnr.4 uc008gnr.5 Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III(CIII) or cytochrome b-c1 complex). Interacts with UQCC1 (PubMed:35977508). Forms a complex, named COMC, composed of UQCC1, UQCC2; UQCC3 and UQCC4; mediates MT-CYB hemylation and association with the first nuclear-encoded complex III subunit UQCRQ (PubMed:35977508). Mitochondrion inner membrane ; Single-pass membrane protein Probably cleaved by OMA1 under mitochondrial stress conditions. Belongs to the UQCC3 family. mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex III mitochondrial electron transport, ubiquinol to cytochrome c ATP biosynthetic process membrane integral component of membrane integral component of mitochondrial inner membrane mitochondrial respiratory chain complex III assembly cristae formation phosphatidic acid binding cardiolipin binding uc008gnr.1 uc008gnr.2 uc008gnr.3 uc008gnr.4 uc008gnr.5 
ENSMUST00000096257.3 Lrrn4cl ENSMUST00000096257.3 LRRN4 C-terminal like, transcript variant 1 (from RefSeq NM_001013019.3) ENSMUST00000096257.1 ENSMUST00000096257.2 LRN4L_MOUSE NM_001013019 Q3TYX2 uc008gnn.1 uc008gnn.2 uc008gnn.3 uc008gnn.4 Membrane ; Single-pass type I membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc008gnn.1 uc008gnn.2 uc008gnn.3 uc008gnn.4 
ENSMUST00000096259.6 Gng3 ENSMUST00000096259.6 guanine nucleotide binding protein (G protein), gamma 3 (from RefSeq NM_010316.3) ENSMUST00000096259.1 ENSMUST00000096259.2 ENSMUST00000096259.3 ENSMUST00000096259.4 ENSMUST00000096259.5 GBG3_MOUSE Gngt3 NM_010316 P29798 P63216 Q61014 uc008gnh.1 uc008gnh.2 uc008gnh.3 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units, alpha, beta and gamma. Forms a complex with GNAO1 and GNB1. Interacts with SCN8A. Cell membrane ; Lipid-anchor ; Cytoplasmic side Abundantly expressed in brain. Low levels in testis. Belongs to the G protein gamma family. GTPase activity heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration postsynaptic density membrane dendrite G-protein beta/gamma-subunit complex G-protein beta-subunit binding cell body uc008gnh.1 uc008gnh.2 uc008gnh.3 
ENSMUST00000096261.5 Polr2g ENSMUST00000096261.5 polymerase (RNA) II (DNA directed) polypeptide G (from RefSeq NM_026329.2) ENSMUST00000096261.1 ENSMUST00000096261.2 ENSMUST00000096261.3 ENSMUST00000096261.4 NM_026329 P52433 P62488 RPB7_MOUSE uc008gna.1 uc008gna.2 uc008gna.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RPB4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA (By similarity). Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex. Nucleus Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family. nuclear-transcribed mRNA catabolic process, exonucleolytic P-body nucleic acid binding single-stranded DNA binding RNA binding single-stranded RNA binding DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm DNA-directed RNA polymerase II, core complex transcription, DNA-templated transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter apoptotic process transferase activity nucleotidyltransferase activity translation initiation factor binding positive regulation of translational initiation positive regulation of nuclear-transcribed mRNA poly(A) tail shortening uc008gna.1 uc008gna.2 uc008gna.3 
ENSMUST00000096265.10 Foxr2 ENSMUST00000096265.10 forkhead box R2 (from RefSeq NM_001034894.3) A2AG72 B2RXE0 ENSMUST00000096265.1 ENSMUST00000096265.2 ENSMUST00000096265.3 ENSMUST00000096265.4 ENSMUST00000096265.5 ENSMUST00000096265.6 ENSMUST00000096265.7 ENSMUST00000096265.8 ENSMUST00000096265.9 FOXR2_MOUSE Foxn6 NM_001034894 Q3UM89 uc009uqs.1 uc009uqs.2 uc009uqs.3 uc009uqs.4 Nucleus Expressed in 9.5 dpc embryo. DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated sequence-specific DNA binding uc009uqs.1 uc009uqs.2 uc009uqs.3 uc009uqs.4 
ENSMUST00000096269.11 Slc22a30 ENSMUST00000096269.11 solute carrier family 22, member 30, transcript variant 1 (from RefSeq NM_177002.4) C730048C13Rik ENSMUST00000096269.1 ENSMUST00000096269.10 ENSMUST00000096269.2 ENSMUST00000096269.3 ENSMUST00000096269.4 ENSMUST00000096269.5 ENSMUST00000096269.6 ENSMUST00000096269.7 ENSMUST00000096269.8 ENSMUST00000096269.9 NM_177002 Q8BWN6 Q96LX3 Q96LX3_MOUSE Slc22a30 uc008gly.1 uc008gly.2 uc008gly.3 Membrane ; Multi- pass membrane protein organic anion transport membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008gly.1 uc008gly.2 uc008gly.3 
ENSMUST00000096272.11 Cpped1 ENSMUST00000096272.11 calcineurin-like phosphoesterase domain containing 1, transcript variant 1 (from RefSeq NM_146067.4) CPPED_MOUSE Cstp1 ENSMUST00000096272.1 ENSMUST00000096272.10 ENSMUST00000096272.2 ENSMUST00000096272.3 ENSMUST00000096272.4 ENSMUST00000096272.5 ENSMUST00000096272.6 ENSMUST00000096272.7 ENSMUST00000096272.8 ENSMUST00000096272.9 NM_146067 Q3UYF7 Q8BFS6 Q8BJQ3 Q8BYB7 Q8K236 Q8R3G2 uc007yfm.1 uc007yfm.2 Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes (By similarity). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations. ; Cytoplasm Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8BFS6-1; Sequence=Displayed; Name=2; IsoId=Q8BFS6-2; Sequence=VSP_031660; Name=3; IsoId=Q8BFS6-3; Sequence=VSP_031661, VSP_031663; Name=4; IsoId=Q8BFS6-4; Sequence=VSP_031664, VSP_031665; Name=5; IsoId=Q8BFS6-5; Sequence=VSP_031659, VSP_031662; Belongs to the metallophosphoesterase superfamily. CPPED1 family. Sequence=AAH25476.1; Type=Erroneous initiation; Evidence=; molecular_function phosphoprotein phosphatase activity cytoplasm cytosol plasma membrane protein dephosphorylation biological_process hydrolase activity metal ion binding uc007yfm.1 uc007yfm.2 
ENSMUST00000096299.9 Htr2c ENSMUST00000096299.9 G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,- dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. (from UniProt P34968) 5HT2C_MOUSE 5ht1c B1ATN5 BC098327 ENSMUST00000096299.1 ENSMUST00000096299.2 ENSMUST00000096299.3 ENSMUST00000096299.4 ENSMUST00000096299.5 ENSMUST00000096299.6 ENSMUST00000096299.7 ENSMUST00000096299.8 Htr1c Htr2c P34968 Q5WRU6 uc009une.1 uc009une.2 uc009une.3 uc009une.4 G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,- dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. Interacts with MPDZ. Interacts with ARRB2 (By similarity). Interacts with MPP3; this interaction stabilizes the receptor at the plasma membrane and prevents the desensitization of the HTR2C receptor- mediated calcium response (PubMed:16914526). Cell membrane; Multi-pass membrane protein. Detected in brain cortex, hypothalamus, brainstem and arcuate nucleus. Detected in the paraventricular nucleus of the hypothalamus. The PDZ domain-binding motif is involved in the interaction with MPDZ. N-glycosylated. No obvious phenotype at birth, but mutant mice are prone to sudden death from seizures. When fed ad libitum, adult mice display higher body weight and increased adiposity compared to wild-type littermates. No difference in body weight is found when they receive the same amount of food as their wild-type littermates, indicating that the increased body weight is due to altered feeding behavior. Overweight older mice develop insulin resistance and impaired glucose tolerance. Young mice exhibit insulin resistance, but normal glucose tolerance, due to increased insulin levels in the blood. Insulin resistance is reversed when Htr2c expression is restored in pro-opiomelacortin neurons. Mutant mice display impaired activation of pro-opiomelacortin neurons in the paraventricular nucleus of the hypothalamus, leading to decreased release of CRH and corticosterone. Likewise, they exhibit blunted behavorial responses to anxiogenic environments and stress. Belongs to the G-protein coupled receptor 1 family. Gq/11-coupled serotonin receptor activity behavioral fear response G-protein coupled receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane cellular calcium ion homeostasis signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger phospholipase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating serotonin receptor signaling pathway serotonin receptor signaling pathway chemical synaptic transmission behavior locomotory behavior feeding behavior drug binding external side of plasma membrane cell surface positive regulation of phosphatidylinositol biosynthetic process positive regulation of gamma-aminobutyric acid secretion positive regulation of acetylcholine secretion, neurotransmission membrane integral component of membrane cGMP-mediated signaling dendrite neurotransmitter receptor activity phospholipase D-activating G-protein coupled receptor signaling pathway regulation of neurological system process regulation of appetite behavioral response to nicotine negative regulation of locomotion response to drug identical protein binding regulation of corticotropin-releasing hormone secretion positive regulation of fat cell differentiation positive regulation of vasoconstriction negative regulation of dopamine metabolic process inositol phosphate-mediated signaling release of sequestered calcium ion into cytosol serotonin binding positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway regulation of sensory perception of pain positive regulation of ERK1 and ERK2 cascade 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding uc009une.1 uc009une.2 uc009une.3 uc009une.4 
ENSMUST00000096313.4 Tbc1d8b ENSMUST00000096313.4 TBC1 domain family, member 8B (from RefSeq NM_001081499.2) A3KGB4 B9EJW4 ENSMUST00000096313.1 ENSMUST00000096313.2 ENSMUST00000096313.3 NM_001081499 TBC8B_MOUSE uc009ukj.1 uc009ukj.2 uc009ukj.3 uc009ukj.4 Involved in vesicular recycling, probably as a RAB11B GTPase- activating protein. Interacts (via domain Rab-GAP TBC) with RAB11B (in GTP-bound form). Cytoplasm, cytosol The arginine and glutamine fingers are critical for the GTPase- activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site. GTPase activator activity calcium ion binding cell intracellular protein transport Rab GTPase binding activation of GTPase activity uc009ukj.1 uc009ukj.2 uc009ukj.3 uc009ukj.4 
ENSMUST00000096314.3 Tex13a ENSMUST00000096314.3 testis expressed 13A (from RefSeq NM_026469.4) A2AFS9 A2AFS9_MOUSE ENSMUST00000096314.1 ENSMUST00000096314.2 NM_026469 Tex13a uc009ujw.1 uc009ujw.2 Belongs to the TEX13 family. molecular_function cellular_component biological_process metal ion binding uc009ujw.1 uc009ujw.2 
ENSMUST00000096321.3 Armcx5 ENSMUST00000096321.3 armadillo repeat containing, X-linked 5 (from RefSeq NM_001009575.6) A2AGB5 ARMX5_MOUSE ENSMUST00000096321.1 ENSMUST00000096321.2 NM_001009575 Q3UZB0 uc009uhl.1 uc009uhl.2 uc009uhl.3 uc009uhl.4 uc009uhl.5 Highly expressed in the developing neural tissues, neural crest derivatives and hind limbs. Belongs to the eutherian X-chromosome-specific Armcx family. molecular_function cellular_component biological_process uc009uhl.1 uc009uhl.2 uc009uhl.3 uc009uhl.4 uc009uhl.5 
ENSMUST00000096332.2 Gm382 ENSMUST00000096332.2 Gm382 (from geneSymbol) AK132934 ENSMUST00000096332.1 uc009uer.1 uc009uer.2 uc009uer.1 uc009uer.2 
ENSMUST00000096338.5 Gpr152 ENSMUST00000096338.5 G protein-coupled receptor 152 (from RefSeq NM_206973.2) ENSMUST00000096338.1 ENSMUST00000096338.2 ENSMUST00000096338.3 ENSMUST00000096338.4 GP152_MOUSE NM_206973 Q499X3 Q8BXS7 uc008fyx.1 uc008fyx.2 uc008fyx.3 uc008fyx.4 uc008fyx.5 Orphan receptor. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc008fyx.1 uc008fyx.2 uc008fyx.3 uc008fyx.4 uc008fyx.5 
ENSMUST00000096356.5 Csf2rb2 ENSMUST00000096356.5 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage), transcript variant 1 (from RefSeq NM_007781.3) Ai2ca ENSMUST00000096356.1 ENSMUST00000096356.2 ENSMUST00000096356.3 ENSMUST00000096356.4 IL3B2_MOUSE Il3r Il3rb2 NM_007781 P26954 uc007woy.1 uc007woy.2 uc007woy.3 uc007woy.4 In mouse, there are two classes of high-affinity IL3 receptors. One contains this IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. Heterodimer of an alpha and a beta subunit. Membrane; Single-pass type I membrane protein. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Belongs to the type I cytokine receptor family. Type 4 subfamily. cytokine receptor activity plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway uc007woy.1 uc007woy.2 uc007woy.3 uc007woy.4 
ENSMUST00000096357.12 Ncf4 ENSMUST00000096357.12 neutrophil cytosolic factor 4, transcript variant 1 (from RefSeq NM_008677.3) ENSMUST00000096357.1 ENSMUST00000096357.10 ENSMUST00000096357.11 ENSMUST00000096357.2 ENSMUST00000096357.3 ENSMUST00000096357.4 ENSMUST00000096357.5 ENSMUST00000096357.6 ENSMUST00000096357.7 ENSMUST00000096357.8 ENSMUST00000096357.9 NCF4_MOUSE NM_008677 P97369 Q3TBC6 uc007wow.1 uc007wow.2 uc007wow.3 uc007wow.4 Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4 (By similarity). Interacts with NCF2 (PubMed:21551061). Interacts wirh NCF1 (By similarity). The NCF2- NCF4 complex interacts with GBP7 (via GB1/RHD3-type G domain) (PubMed:21551061). Cytoplasm, cytosol Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane ; Peripheral membrane protein The PB1 domain mediates the association with NCF2/p67-PHOX. The PX domain mediates interaction with membranes enriched in phosphatidylnositol 3-phosphate. protein binding cytoplasm endosome cytosol superoxide metabolic process phagocytosis lipid binding endosome membrane membrane superoxide-generating NADPH oxidase activator activity phosphatidylinositol-3-phosphate binding phosphatidylinositol binding NADPH oxidase complex positive regulation of catalytic activity respiratory burst uc007wow.1 uc007wow.2 uc007wow.3 uc007wow.4 
ENSMUST00000096358.6 Apol7e ENSMUST00000096358.6 apolipoprotein L 7e (from RefSeq NM_001134802.1) Apol7b Apol7e BC085284 ENSMUST00000096358.1 ENSMUST00000096358.2 ENSMUST00000096358.3 ENSMUST00000096358.4 ENSMUST00000096358.5 NM_001134802 Q3UZ24 Q3UZ24_MOUSE uc007wnx.1 uc007wnx.2 uc007wnx.3 Belongs to the apolipoprotein L family. cellular_component extracellular region lipid transport lipid binding lipoprotein metabolic process uc007wnx.1 uc007wnx.2 uc007wnx.3 
ENSMUST00000096361.5 Awat1 ENSMUST00000096361.5 acyl-CoA wax alcohol acyltransferase 1 (from RefSeq NM_001081136.1) A2ADU9 AWAT1_MOUSE B2RW94 Dgat2l3 ENSMUST00000096361.1 ENSMUST00000096361.2 ENSMUST00000096361.3 ENSMUST00000096361.4 NM_001081136 uc009twb.1 uc009twb.2 uc009twb.3 Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (By similarity). Shows a strong preference for decyl alcohol (C10), with less activity towards C16 and C18 alcohols (By similarity). Shows a strong preference for saturated acyl-CoAs (By similarity). Reaction=a fatty acyl-CoA + a long chain fatty alcohol = a wax ester + CoA; Xref=Rhea:RHEA:38443, ChEBI:CHEBI:10036, ChEBI:CHEBI:17135, ChEBI:CHEBI:57287, ChEBI:CHEBI:77636; EC=2.3.1.75; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38444; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219, ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38220; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9Z)-octadecenoate; Xref=Rhea:RHEA:38227, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75622; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38228; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + decan-1-ol = 1-O-decyl-(9Z)- octadecenoate + CoA; Xref=Rhea:RHEA:38223, ChEBI:CHEBI:28903, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75620; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38224; Evidence=; Reaction=(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)- hexadecenyl (9Z)-octadecenoate + CoA; Xref=Rhea:RHEA:38231, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75623, ChEBI:CHEBI:75624; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38232; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + octadecan-1-ol = 1-O-octadecyl (9Z)- octadecenoate + CoA; Xref=Rhea:RHEA:38235, ChEBI:CHEBI:32154, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75625; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38236; Evidence=; Reaction=(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)- octadecenyl (9Z)-octadecenoate + CoA; Xref=Rhea:RHEA:38239, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:73504, ChEBI:CHEBI:75626; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38240; Evidence=; Reaction=hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoate; Xref=Rhea:RHEA:38167, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75584; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38168; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + hexadecan-1-ol = 1-O-hexadecyl (9Z)- hexadecenoate + CoA; Xref=Rhea:RHEA:38247, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:75629; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38248; Evidence=; Reaction=hexadecan-1-ol + octadecanoyl-CoA = CoA + hexadecanyl octadecanoate; Xref=Rhea:RHEA:38251, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:75631; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38252; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + eicosan-1-ol = 1-O-eicosanyl (9Z)- octadecenoate + CoA; Xref=Rhea:RHEA:38243, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75627, ChEBI:CHEBI:75628; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38244; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the diacylglycerol acyltransferase family. cellular_component endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process biological_process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups long-chain-alcohol O-fatty-acyltransferase activity uc009twb.1 uc009twb.2 uc009twb.3 
ENSMUST00000096363.3 Nalf2 ENSMUST00000096363.3 NALCN channel auxiliary factor 2 (from RefSeq NM_001081283.2) A2BDP1 ENSMUST00000096363.1 ENSMUST00000096363.2 Fam155b NALF2_MOUSE NM_001081283 Tmem28 uc009tvn.1 uc009tvn.2 uc009tvn.3 Probable component of the NALCN channel complex, a channel that regulates the resting membrane potential and controls neuronal excitability. Membrane ; Multi-pass membrane protein Belongs to the NALF family. plasma membrane membrane integral component of membrane calcium ion import across plasma membrane stretch-activated, cation-selective, calcium channel activity uc009tvn.1 uc009tvn.2 uc009tvn.3 
ENSMUST00000096365.5 Scrt1 ENSMUST00000096365.5 scratch family zinc finger 1 (from RefSeq NM_130893.3) ENSMUST00000096365.1 ENSMUST00000096365.2 ENSMUST00000096365.3 ENSMUST00000096365.4 NM_130893 Q99M85 SCRT1_MOUSE uc007wko.1 uc007wko.2 uc007wko.3 Transcriptional repressor that binds E-box motif CAGGTG (By similarity). Appears to function downstream of proneural bHLH proteins in promoting neural differentiation. Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Nucleus Detected throughout the spinal cord except in the ventricular zone surrounding the central canal, which contains proliferating neurons, and dorsal root ganglia at 11.5 dpc. At 12.5 dpc, detected in the telencephalon, and by 14.5 dpc a distinct laminar pattern of expression was seen in regions adjacent to the ventricular zone. In the developing eye, expression was detected in the inner nuclear layer of the retina beginning at 13.5 dpc. The N-terminal non zinc-finger region mediates the repressor activity. Belongs to the snail C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated nuclear body sequence-specific DNA binding metal ion binding regulation of neuron migration uc007wko.1 uc007wko.2 uc007wko.3 
ENSMUST00000096366.6 1700010D01Rik ENSMUST00000096366.6 RIKEN cDNA 1700010D01 gene (from RefSeq NR_165046.1) ENSMUST00000096366.1 ENSMUST00000096366.2 ENSMUST00000096366.3 ENSMUST00000096366.4 ENSMUST00000096366.5 NR_165046 uc009tuc.1 uc009tuc.2 uc009tuc.3 uc009tuc.4 uc009tuc.1 uc009tuc.2 uc009tuc.3 uc009tuc.4 
ENSMUST00000096367.5 Spin4 ENSMUST00000096367.5 spindlin family, member 4 (from RefSeq NM_178753.4) ENSMUST00000096367.1 ENSMUST00000096367.2 ENSMUST00000096367.3 ENSMUST00000096367.4 NM_178753 Q8BXD0 Q8K1L2 SPIN4_MOUSE uc009tts.1 uc009tts.2 uc009tts.3 uc009tts.4 Exhibits H3K4me3-binding activity. Interacts with C11orf84/SPINDOC. Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation biological_process methylated histone binding uc009tts.1 uc009tts.2 uc009tts.3 uc009tts.4 
ENSMUST00000096368.4 Gspt2 ENSMUST00000096368.4 G1 to S phase transition 2 (from RefSeq NM_008179.2) ENSMUST00000096368.1 ENSMUST00000096368.2 ENSMUST00000096368.3 ERF3B_MOUSE Erf3b NM_008179 O88180 Q149F3 Q9CY91 uc009tto.1 uc009tto.2 uc009tto.3 uc009tto.4 GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:12354098). GSPT2/ERF3B mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (By similarity). GTP hydrolysis by GSPT2/ERF3B induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A- site (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Component of the eRF1-eRF3-GTP ternary complex, composed of ETF1/ERF1 and ERF3 (GSPT1/ERF3A or GSPT2/ERF3B) and GTP (PubMed:12354098). Component of the transient SURF (SMG1-UPF1-eRF1- eRF3) complex (By similarity). Interacts with UPF1 and PABPC1 (By similarity). Cytoplasm Highly expressed in brain. Moderately expressed in spleen and lung. Weakly expressed in heart, liver and kidney. Expression during the cell-cycle progression is constant. Barely detectable at 15 dpc, increased after birth to reach a maximum at P15. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily. Sequence=BAA32527.1; Type=Erroneous initiation; Evidence=; Sequence=BAB31621.1; Type=Frameshift; Evidence=; nucleotide binding nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cytoplasmic translational termination translation release factor activity GTPase activity GTP binding cytoplasm cytosol translation cell cycle translation release factor complex uc009tto.1 uc009tto.2 uc009tto.3 uc009tto.4 
ENSMUST00000096371.3 Gm5941 ENSMUST00000096371.3 predicted gene 5941 (from RefSeq NR_165047.1) EG546347 ENSMUST00000096371.1 ENSMUST00000096371.2 Gm5941 NR_165047 Q497P9 Q497P9_MOUSE uc009tso.1 uc009tso.2 uc009tso.3 molecular_function cellular_component biological_process uc009tso.1 uc009tso.2 uc009tso.3 
ENSMUST00000096378.3 Mageb4 ENSMUST00000096378.3 Cytoplasm (from UniProt A2A9R3) A2A9R3 AK144350 B7ZWI9 ENSMUST00000096378.1 ENSMUST00000096378.2 MAGB4_MOUSE Mageb4 Q3UNA3 uc033jrb.1 uc033jrb.2 uc033jrb.3 Cytoplasm Expressed in testis (at protein level). Detected between 13.5 and 14.5 dpc in both female and male gonads (at protein level). Increases in the male gonads and intensely expressed before birth (at protein level). In female gonads, remains constant until birth (at protein level). In testis, specifically expressed in premeiotic germ cells (at protein level). In fetal ovary, expressed in both premeiotic germ cells, and germ cells that have gone through the pachytene phase and entered meiotic arrest (at protein level). molecular_function cytoplasm biological_process uc033jrb.1 uc033jrb.2 uc033jrb.3 
ENSMUST00000096385.11 Mroh1 ENSMUST00000096385.11 maestro heat-like repeat family member 1, transcript variant 1 (from RefSeq NM_175457.4) E0CZ22 E0CZ22_MOUSE ENSMUST00000096385.1 ENSMUST00000096385.10 ENSMUST00000096385.2 ENSMUST00000096385.3 ENSMUST00000096385.4 ENSMUST00000096385.5 ENSMUST00000096385.6 ENSMUST00000096385.7 ENSMUST00000096385.8 ENSMUST00000096385.9 Heatr7a Mroh1 NM_175457 uc007wkc.1 uc007wkc.2 uc007wkc.3 uc007wkc.4 molecular_function cellular_component biological_process uc007wkc.1 uc007wkc.2 uc007wkc.3 uc007wkc.4 
ENSMUST00000096389.5 Cldn34b3 ENSMUST00000096389.5 claudin 34B3 (from RefSeq NM_001013760.3) Cldn34b3 EG238829 ENSMUST00000096389.1 ENSMUST00000096389.2 ENSMUST00000096389.3 ENSMUST00000096389.4 Gm4937 NM_001013760 Q80ZS5 Q80ZS5_MOUSE uc009tql.1 uc009tql.2 uc009tql.3 Cell junction, tight junction Belongs to the claudin family. molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc009tql.1 uc009tql.2 uc009tql.3 
ENSMUST00000096418.5 A1bg ENSMUST00000096418.5 alpha-1-B glycoprotein (from RefSeq NM_001081067.1) A1BG_MOUSE ENSMUST00000096418.1 ENSMUST00000096418.2 ENSMUST00000096418.3 ENSMUST00000096418.4 NM_001081067 Q19LI2 uc007vyd.1 uc007vyd.2 uc007vyd.3 Interacts with CRISP3. Secreted Expressed in the liver hepatocytes of male and female GH transgenic mice and in the liver of female, but not of male, non-transgenic mice. Expressed at 3-days but not at 11-days of age in both female and male GH transgenic mice. Expression in the normal female mice begins as early as 2 months and is detected at much higher levels at 5, 12 and 24 months while at 30 months, expression is lower. Induced in hepatocytes during the proliferative phase of liver regeneration. Induction requires a continuous pattern of GH (growth hormaone) secretion and an intact GH-GH receptor-signaling complex. molecular_function extracellular region biological_process uc007vyd.1 uc007vyd.2 uc007vyd.3 
ENSMUST00000096420.3 Styx-ps ENSMUST00000096420.3 Catalytically inactive phosphatase (PubMed:7592916). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (By similarity). Plays a role in spermatogenesis (PubMed:11842224). (from UniProt Q60969) BC038608 ENSMUST00000096420.1 ENSMUST00000096420.2 Q3TMA3 Q60969 Q60970 Q9DCF8 STYX_MOUSE Styx uc292omk.1 uc292omk.2 Catalytically inactive phosphatase (PubMed:7592916). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (By similarity). Plays a role in spermatogenesis (PubMed:11842224). Interacts with MAPK1; independently of MAPK1 phosphorylation status (By similarity). Interacts with CARHSP1/Crhsp-24 (PubMed:11842224). Interacts (via FQQ motif) with FBXW7 (via F-box domain); the interaction is direct and prevents FBXW7 interaction with SKP1, a component of the SCF(FBXW7) complex (By similarity). Nucleus Cytoplasm, cytosol Note=Predominantly localizes to the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60969-1; Sequence=Displayed; Name=2; IsoId=Q60969-2; Sequence=VSP_005174; Widely expressed with highest levels in muscle, testis and brain (PubMed:7592916). In testis, expression starts 13-14 days after birth and is limited to the seminiferous tubule and to round and elongating spermatids (PubMed:11842224). Expression is low in condensing spermatids and pachytene spermatocytes, and absent in spermatogonia, spermatozoa and somatic Sertoli cells (PubMed:11842224). Males are infertile due to a disrupted spermatid development, resulting in a >1000-fold decrease in spermatozoa production. Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. Contains a Gly residue instead of a conserved Cys residue at position 120 in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and may protect them from phosphatases. pseudophosphatase activity protein binding nucleus nucleoplasm cytoplasm cytosol protein dephosphorylation spermatogenesis protein tyrosine/serine/threonine phosphatase activity dephosphorylation phosphatase activity negative regulation of protein binding negative regulation of catalytic activity MAPK export from nucleus regulation of ERK1 and ERK2 cascade F-box domain binding uc292omk.1 uc292omk.2 
ENSMUST00000096421.4 4933412E24Rik ENSMUST00000096421.4 RIKEN cDNA 4933412E24 gene (from RefSeq NM_027668.1) CX049_MOUSE ENSMUST00000096421.1 ENSMUST00000096421.2 ENSMUST00000096421.3 NM_027668 Q9D454 uc011ztd.1 uc011ztd.2 uc011ztd.3 molecular_function cellular_component biological_process uc011ztd.1 uc011ztd.2 uc011ztd.3 
ENSMUST00000096430.11 Zhx2 ENSMUST00000096430.11 zinc fingers and homeoboxes 2 (from RefSeq NM_199449.2) Afr1 ENSMUST00000096430.1 ENSMUST00000096430.10 ENSMUST00000096430.2 ENSMUST00000096430.3 ENSMUST00000096430.4 ENSMUST00000096430.5 ENSMUST00000096430.6 ENSMUST00000096430.7 ENSMUST00000096430.8 ENSMUST00000096430.9 NM_199449 Q8C0C0 Raf ZHX2_MOUSE uc007vsp.1 uc007vsp.2 uc007vsp.3 Acts as a transcriptional repressor (PubMed:19515908). Represses the promoter activity of the CDC25C gene stimulated by NFYA (By similarity). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (PubMed:30146259). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (PubMed:19515908). Homodimer (via homeobox domain 1) (By similarity). Heterodimer with ZHX1 (via homeobox domain 1) (By similarity). Heterodimer with ZHX3 (via homeobox domain 1) (By similarity). Heterodimerization with ZHX1 is not necessary for repressor activity (By similarity). Interacts (via homeobox domain) with NFYA (via N-terminus) (By similarity). Interacts with EFNB1 intracellular domain peptide; the interaction enhances ZHX2 transcriptional repression activity (PubMed:19515908). Q8C0C0; Q8BUR4: Dock1; NbExp=3; IntAct=EBI-646042, EBI-646023; Nucleus te=Colocalizes with EFNB1 intracellular domain in the nucleus. Expressed in retina where it localizes to Muller glial cells of the inner nuclear layer (at protein level) (PubMed:30146259). Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis (PubMed:14659886). Strongly expressed in retina from embryonic stages 14.5 dpc to 17.5 dpc, where it is widely detected in retinal progenitor cells (at protein level) (PubMed:30146259). Expression then gradually declines and stabilizes at a low level by postnatal day 10 (P10) (at protein level) (PubMed:30146259). At P0, expression refines to the inner half of the neuroblastic layer (at protein level) (PubMed:30146259). Expression further refines to the retinal inner nuclear layer from stage P3 onwards (at protein level) (PubMed:30146259). Detected in bipolar OFF-type cells at stage P7 (at protein level) (PubMed:30146259). By stage P10, has only weak expression in bipolar OFF-type cells but strong expression in Muller glial cells (at protein level) (PubMed:30146259). Detected in brain at embryonic stages 12.5 dpc to 15.5 dpc, specifically in the ventricular zone and subventricular zone of the cortex (at protein level) (PubMed:19515908). Probably localizes to neural progenitor cells in the developing cortex (at protein level) (PubMed:19515908). Belongs to the ZHX family. negative regulation of transcription from RNA polymerase II promoter nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus nucleoplasm cytosol plasma membrane regulation of transcription from RNA polymerase II promoter mRNA catabolic process nervous system development cell differentiation somatic stem cell population maintenance identical protein binding protein homodimerization activity negative regulation of neuron differentiation negative regulation of transcription, DNA-templated metal ion binding protein heterodimerization activity retinal bipolar neuron differentiation uc007vsp.1 uc007vsp.2 uc007vsp.3 
ENSMUST00000096433.10 Deptor ENSMUST00000096433.10 DEP domain containing MTOR-interacting protein, transcript variant 1 (from RefSeq NM_145470.4) DPTOR_MOUSE Depdc6 Deptor ENSMUST00000096433.1 ENSMUST00000096433.2 ENSMUST00000096433.3 ENSMUST00000096433.4 ENSMUST00000096433.5 ENSMUST00000096433.6 ENSMUST00000096433.7 ENSMUST00000096433.8 ENSMUST00000096433.9 Kiaa4200 NM_145470 Q3UM00 Q3UT08 Q570Y9 uc007vsb.1 uc007vsb.2 uc007vsb.3 uc007vsb.4 Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes. DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy. In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity. Inhibited upon phosphatidic acid-binding: phosphatidic acid produced upon mitogenic stimulation promotes DEPTOR dissociatiom from the mTORC1 and mTORC2 complexes, leading to their activation. Specifically binds unsaturated phosphatidic acid, such as 16:0-18:1, 18:0-18:1 and di-18:1. Inhibited when nutrients are present via a feedback loop: phosphorylation by MTOR promotes DEPTOR ubiquitination and degradation. Associated component of the mechanistic target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8 and RPTOR. Associated component of the mechanistic target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PROTOR1, RICTOR, MAPKAP1 and DEPTOR. Interacts (via PDZ domain) with MTOR; interacts with MTOR within both mTORC1 and mTORC2. Interacts (via PDZ domain) with MINAR1 (via N- terminus). Interacts with SIK3. Lysosome membrane Note=Localizes to the lysosomal membrane when associated with the mTORC1 and mTORC2 complexes. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q570Y9-1; Sequence=Displayed; Name=2; IsoId=Q570Y9-2; Sequence=VSP_024648; Name=3; IsoId=Q570Y9-3; Sequence=VSP_024649; At postnatal day 1 (P1), in cartilage growth plate, primarily expressed in resting and proliferating chondrocytes. This expression pattern is maintained at least until P21 (at protein level). Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2 (By similarity). Phosphorylated at Ser-286, Ser-287 and Ser-291 in response to mitogenic stimulation by MTOR: DEPTOR is either directly phosphorylated by MTOR or indirectly via proteins kinases that are activated by MTOR, such as CK1/CSNK1A1 (By similarity). Phosphorylation at Ser-286, Ser-287 and Ser-291 promotes ubiquitination by the SCF(BTRC) complex, followed by degradation (By similarity). Phosphorylation at Ser-235 by MAPK3/ERK1 promotes deubiquitination by USP7, enhancing its stability (By similarity). Phosphorylation at Tyr- 291 by SYK impairs its interaction with MTOR, promoting mTORC1 and mTORC2 signaling (By similarity). Ubiquitinated; leading to proteasomal degradation (By similarity). Ubiquitination by the SCF(BTRC) and SCF(FBXW11) complexes following phosphorylation at Ser-286, Ser-287 and Ser-291 by MTOR, leads to its degradation by the proteasome (By similarity). Deubiquitinated by OTUB1 in response to amino acid via a non-canonical mechanism, leading to DEPTOR stability (By similarity). Deubiquitinated by USP7 following phosphorylation at Ser-235, promoting its stability (By similarity). Sequence=BAD90225.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of protein kinase activity negative regulation of TOR signaling intracellular signal transduction negative regulation of cell size regulation of extrinsic apoptotic signaling pathway uc007vsb.1 uc007vsb.2 uc007vsb.3 uc007vsb.4 
ENSMUST00000096441.5 Morc2a ENSMUST00000096441.5 microrchidia 2A, transcript variant 2 (from RefSeq NM_198162.2) ENSMUST00000096441.1 ENSMUST00000096441.2 ENSMUST00000096441.3 ENSMUST00000096441.4 Kiaa0852 MOR2A_MOUSE Morc2a NM_198162 Q5QNQ7 Q69ZX6 Q6P547 Zcwcc1 uc287wfd.1 uc287wfd.2 uc287wfd.3 Essential for epigenetic silencing by the HUSH complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (By similarity). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark (PubMed:29728365). Silencing events often occur within introns of transcriptionally active genes, and lead to the down- regulation of host gene expression. During DNA damage response, regulates chromatin remodeling through ATP hydrolysis (By similarity). During DNA damage response, may regulate chromatin remodeling through ATP hydrolysis (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; ATPase activity is dependent of phosphorylation by PAK1 and presence of DNA. Homodimerizes upon ATP-binding and dissociate upon ATP hydrolysis; homodimerization is required for gene silencing (By similarity). Binds histone H3 independently of the methylation status at 'Lys-9' (PubMed:29728365). Interacts with HDAC4. Interacts with FAM208A/TASOR and MPHOSPH8; the interactions associate MORC2 with the HUSH complex which recruits MORC2 to heterochromatic loci (By similarity). Interacts with Morc2b (PubMed:29329290). Nucleus Cytoplasm, cytosol Chromosome Nucleus matrix Note=Mainly located in the nucleus. Upon phosphorylation at Ser-737, recruited to damaged chromatin. Expressed in the axons and Schwann cells of peripheral nerves. Expressed in testes (PubMed:29329290). Phosphorylated by PAK1 at Ser-737 upon DNA damage. Phosphorylation is required for ATPase activity and recruitment to damaged chromatin. Sequence=BAD32320.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding magnesium ion binding heterochromatin chromatin binding protein binding ATP binding nucleus chromosome cytoplasm cytosol chromatin remodeling cellular response to DNA damage stimulus zinc ion binding nuclear matrix hydrolase activity ATPase activity histone binding protein homodimerization activity negative regulation of gene expression, epigenetic negative regulation of single stranded viral RNA replication via double stranded DNA intermediate metal ion binding positive regulation of methylation-dependent chromatin silencing uc287wfd.1 uc287wfd.2 uc287wfd.3 
ENSMUST00000096453.12 Rhox12 ENSMUST00000096453.12 reproductive homeobox 12 (from RefSeq NM_001025083.2) ENSMUST00000096453.1 ENSMUST00000096453.10 ENSMUST00000096453.11 ENSMUST00000096453.2 ENSMUST00000096453.3 ENSMUST00000096453.4 ENSMUST00000096453.5 ENSMUST00000096453.6 ENSMUST00000096453.7 ENSMUST00000096453.8 ENSMUST00000096453.9 NM_001025083 Q4TU81 Q4TU81_MOUSE Rhox12 uc009szn.1 uc009szn.2 uc009szn.3 Nucleus DNA binding nucleus uc009szn.1 uc009szn.2 uc009szn.3 
ENSMUST00000096454.2 Rhox7a ENSMUST00000096454.2 reproductive homeobox 7A (from RefSeq NM_001025086.2) A2A4F1 A2A4F1_MOUSE ENSMUST00000096454.1 NM_001025086 Rhox7a uc009szh.1 uc009szh.2 Nucleus DNA binding cellular_component nucleus biological_process uc009szh.1 uc009szh.2 
ENSMUST00000096457.7 Rhox3h ENSMUST00000096457.7 reproductive homeobox 3H (from RefSeq NM_001114157.1) ENSMUST00000096457.1 ENSMUST00000096457.2 ENSMUST00000096457.3 ENSMUST00000096457.4 ENSMUST00000096457.5 ENSMUST00000096457.6 L7MU37 L7MU37_MOUSE NM_001114157 Rhox3h uc012hgj.1 uc012hgj.2 Nucleus DNA binding cellular_component nucleus biological_process uc012hgj.1 uc012hgj.2 
ENSMUST00000096458.5 Rhox4b ENSMUST00000096458.5 reproductive homeobox 4B (from RefSeq NM_021300.2) ENSMUST00000096458.1 ENSMUST00000096458.2 ENSMUST00000096458.3 ENSMUST00000096458.4 Ehox NM_021300 Q9JI43 Q9JI43_MOUSE Rhox4.2 Rhox4b uc009syr.1 uc009syr.2 uc009syr.3 Nucleus DNA binding cellular_component nucleus biological_process uc009syr.1 uc009syr.2 uc009syr.3 
ENSMUST00000096469.7 Gm5169 ENSMUST00000096469.7 predicted gene 5169 (from RefSeq NM_001040669.2) 382277 EG382275 EG546272 ENSMUST00000096469.1 ENSMUST00000096469.2 ENSMUST00000096469.3 ENSMUST00000096469.4 ENSMUST00000096469.5 ENSMUST00000096469.6 Gm5169 NM_001040669 Q5M8P2 Q5M8P2_MOUSE uc009svg.1 uc009svg.2 uc009svg.3 uc009svg.4 uc009svg.5 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc009svg.1 uc009svg.2 uc009svg.3 uc009svg.4 uc009svg.5 
ENSMUST00000096482.10 Skp2 ENSMUST00000096482.10 S-phase kinase-associated protein 2, transcript variant 1 (from RefSeq NM_013787.3) ENSMUST00000096482.1 ENSMUST00000096482.2 ENSMUST00000096482.3 ENSMUST00000096482.4 ENSMUST00000096482.5 ENSMUST00000096482.6 ENSMUST00000096482.7 ENSMUST00000096482.8 ENSMUST00000096482.9 NM_013787 Q8BSG7 Q8C8Y9 Q8CB22 Q99J53 Q9Z0Z3 SKP2_MOUSE uc007vff.1 uc007vff.2 uc007vff.3 uc007vff.4 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (By similarity). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (PubMed:10790373). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (By similarity). Through the ubiquitin-mediated proteasomal degradation of viral proteins may have an antiviral activity. Protein modification; protein ubiquitination. Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with ASB2 which is the substrate-recognition component of a probable ECS E3 ubiquitin-protein ligase complex; ASB2 is likely to bridge the formation of dimeric E3-ubiquitin-protein ligase complexes composed of an ECS complex and an SCF(SKP2) complex. Interacts with CKS1. Interacts with the cyclin-A-CDK2 complex. Interacts with ORC1, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1, UBP43, MYC, TOB1, TAL1 and KMT2A/MLL1. Interacts with TRIM21 (By similarity). Interacts with cyclin-E (PubMed:10790373). Interacts with CARM1 (PubMed:30366907). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Z0Z3-1; Sequence=Displayed; Name=2; IsoId=Q9Z0Z3-2; Sequence=VSP_008434; Name=3; IsoId=Q9Z0Z3-3; Sequence=VSP_008433; Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13 (By similarity). Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3 (By similarity). G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle protein polyubiquitination protein binding nucleus nucleolus cytoplasm cytosol ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process positive regulation of intracellular estrogen receptor signaling pathway identical protein binding regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process innate immune response positive regulation of smooth muscle cell proliferation defense response to virus regulation of cell cycle protein K48-linked ubiquitination cellular response to cell-matrix adhesion positive regulation of protein polyubiquitination ubiquitin protein ligase activity uc007vff.1 uc007vff.2 uc007vff.3 uc007vff.4 
ENSMUST00000096495.11 Med14 ENSMUST00000096495.11 mediator complex subunit 14, transcript variant 2 (from RefSeq NM_012005.3) A2ABV5 Crsp2 ENSMUST00000096495.1 ENSMUST00000096495.10 ENSMUST00000096495.2 ENSMUST00000096495.3 ENSMUST00000096495.4 ENSMUST00000096495.5 ENSMUST00000096495.6 ENSMUST00000096495.7 ENSMUST00000096495.8 ENSMUST00000096495.9 Gm641 MED14_MOUSE NM_012005 Q3TQU3 Q6P1H5 Q9R0T1 Q9WTN9 Trap170 uc009sqz.1 uc009sqz.2 uc009sqz.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR, ESR1, SREBF1 and STAT2 (By similarity). Interacts with GATA1. Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=A2ABV5-1; Sequence=Displayed; Name=2; IsoId=A2ABV5-2; Sequence=VSP_028037, VSP_028038; Name=3; IsoId=A2ABV5-3; Sequence=VSP_028035, VSP_028036; Name=4; IsoId=A2ABV5-4; Sequence=VSP_028033, VSP_028034; Belongs to the Mediator complex subunit 14 family. transcription cofactor activity transcription coactivator activity nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter mediator complex stem cell population maintenance positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter core mediator complex uc009sqz.1 uc009sqz.2 uc009sqz.3 
ENSMUST00000096509.7 Fthl17e ENSMUST00000096509.7 ferritin, heavy polypeptide-like 17, member E (from RefSeq NM_031261.2) ENSMUST00000096509.1 ENSMUST00000096509.2 ENSMUST00000096509.3 ENSMUST00000096509.4 ENSMUST00000096509.5 ENSMUST00000096509.6 FH17E_MOUSE Fthl17 Fthl17e L7MU38 NM_031261 Q99MX2 uc009spm.1 uc009spm.2 uc009spm.3 Expressed in the testes and spermatogonia. Belongs to the ferritin family. ferroxidase activity iron ion binding cytoplasm iron ion transport cellular iron ion homeostasis intracellular sequestering of iron ion ferrous iron binding ferric iron binding identical protein binding metal ion binding oxidation-reduction process uc009spm.1 uc009spm.2 uc009spm.3 
ENSMUST00000096570.4 Gm94 ENSMUST00000096570.4 predicted gene 94 (from RefSeq NM_001033280.2) CE046_MOUSE ENSMUST00000096570.1 ENSMUST00000096570.2 ENSMUST00000096570.3 NM_001033280 Q3V2D2 uc008euo.1 uc008euo.2 Secreted molecular_function cellular_component extracellular region biological_process uc008euo.1 uc008euo.2 
ENSMUST00000096575.5 Map3k2 ENSMUST00000096575.5 mitogen-activated protein kinase kinase kinase 2 (from RefSeq NM_011946.3) ENSMUST00000096575.1 ENSMUST00000096575.2 ENSMUST00000096575.3 ENSMUST00000096575.4 G5E8L8 G5E8L8_MOUSE Map3k2 NM_011946 uc008ejd.1 uc008ejd.2 uc008ejd.3 uc008ejd.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. MAPK cascade activation of MAPKK activity protein kinase activity MAP kinase kinase kinase activity ATP binding nucleus nucleoplasm cytosol protein phosphorylation kinase activity phosphorylation protein kinase binding positive regulation of transcription, DNA-templated cellular response to mechanical stimulus uc008ejd.1 uc008ejd.2 uc008ejd.3 uc008ejd.4 
ENSMUST00000096608.5 Mroh9 ENSMUST00000096608.5 maestro heat-like repeat family member 9 (from RefSeq NM_030071.1) 4921528O07Rik Armc11 ENSMUST00000096608.1 ENSMUST00000096608.2 ENSMUST00000096608.3 ENSMUST00000096608.4 G5E8L9 G5E8L9_MOUSE Mroh9 NM_030071 uc007dhg.1 uc007dhg.2 uc007dhg.3 molecular_function cellular_component biological_process uc007dhg.1 uc007dhg.2 uc007dhg.3 
ENSMUST00000096633.3 Nutm2 ENSMUST00000096633.3 NUT family member 2 (from RefSeq NM_001033400.2) ENSMUST00000096633.1 ENSMUST00000096633.2 Gm806 NM_001033400 NUTM2_MOUSE Nutm2 Q3V0C3 uc007qkn.1 uc007qkn.2 Belongs to the NUT family. molecular_function cellular_component biological_process uc007qkn.1 uc007qkn.2 
ENSMUST00000096639.12 Rnf121 ENSMUST00000096639.12 ring finger protein 121, transcript variant 1 (from RefSeq NM_029211.3) ENSMUST00000096639.1 ENSMUST00000096639.10 ENSMUST00000096639.11 ENSMUST00000096639.2 ENSMUST00000096639.3 ENSMUST00000096639.4 ENSMUST00000096639.5 ENSMUST00000096639.6 ENSMUST00000096639.7 ENSMUST00000096639.8 ENSMUST00000096639.9 NM_029211 Q3TXH5 Q8BP06 Q8BSB1 Q8R1Z9 Q9D4X4 RN121_MOUSE uc009iqg.1 uc009iqg.2 uc009iqg.3 E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates thereby promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (By similarity). May regulate the unfolded protein response to reduce endoplasmic reticulum stress (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R1Z9-1; Sequence=Displayed; Name=2; IsoId=Q8R1Z9-2; Sequence=VSP_021683; Name=3; IsoId=Q8R1Z9-3; Sequence=VSP_021684; Belongs to the RNF121 family. Sequence=BAC37314.1; Type=Erroneous initiation; Evidence=; Golgi membrane endoplasmic reticulum membrane membrane integral component of membrane protein ubiquitination ER-associated ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity uc009iqg.1 uc009iqg.2 uc009iqg.3 
ENSMUST00000096663.5 Adam25 ENSMUST00000096663.5 ADAM metallopeptidase domain 25 (from RefSeq NM_011781.3) A0A0R4J160 A0A0R4J160_MOUSE Adam25 ENSMUST00000096663.1 ENSMUST00000096663.2 ENSMUST00000096663.3 ENSMUST00000096663.4 NM_011781 uc009lnc.1 uc009lnc.2 uc009lnc.3 uc009lnc.4 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. This gene is located adjacent to other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]. ##Evidence-Data-START## Transcript exon combination :: AF167403.1, AK016581.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN00849390 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Lacks conserved residue(s) required for the propagation of feature annotation. metalloendopeptidase activity proteolysis metallopeptidase activity membrane integral component of membrane uc009lnc.1 uc009lnc.2 uc009lnc.3 uc009lnc.4 
ENSMUST00000096691.5 Il22 ENSMUST00000096691.5 interleukin 22 (from RefSeq NM_016971.2) ENSMUST00000096691.1 ENSMUST00000096691.2 ENSMUST00000096691.3 ENSMUST00000096691.4 IL22_MOUSE Il22a Iltif Iltifa NM_016971 Q14BB3 Q9JJY9 uc007hdv.1 uc007hdv.2 uc007hdv.3 uc007hdv.4 uc007hdv.5 Cytokine that plays a critical role in modulating tissue responses during inflammation (PubMed:35525330, PubMed:33852830). Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage (PubMed:33912578). Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non- immune cells in many organs and the shared subunit IL10RB. Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways. Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN (PubMed:24742671). Promotes epithelial cell spreading (PubMed:24742671). Secreted. Deletion mice have an enhanced response to agricultural dust as evidenced by an exacerbated increase in infiltrating immune cells and lung pathology as compared to wild-type controls (PubMed:35525330). In addition, T-gondii-infected mice display a significant defect of the epithelial barrier and an increase in macromolecular permeability when compared to wild-type mice (PubMed:33912578). Belongs to the IL-10 family. cytokine activity protein binding extracellular region extracellular space signal transduction regulation of tyrosine phosphorylation of STAT protein positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response reactive oxygen species metabolic process uc007hdv.1 uc007hdv.2 uc007hdv.3 uc007hdv.4 uc007hdv.5 
ENSMUST00000096751.11 Ttc9c ENSMUST00000096751.11 tetratricopeptide repeat domain 9C (from RefSeq NM_027412.3) ENSMUST00000096751.1 ENSMUST00000096751.10 ENSMUST00000096751.2 ENSMUST00000096751.3 ENSMUST00000096751.4 ENSMUST00000096751.5 ENSMUST00000096751.6 ENSMUST00000096751.7 ENSMUST00000096751.8 ENSMUST00000096751.9 NM_027412 Q810A3 Q9D7W8 TTC9C_MOUSE uc008gnf.1 uc008gnf.2 uc008gnf.3 Belongs to the TTC9 family. uc008gnf.1 uc008gnf.2 uc008gnf.3 
ENSMUST00000096753.5 Hnrnpul2 ENSMUST00000096753.5 heterogeneous nuclear ribonucleoprotein U-like 2 (from RefSeq NM_001081196.1) ENSMUST00000096753.1 ENSMUST00000096753.2 ENSMUST00000096753.3 ENSMUST00000096753.4 F8VPM4 HNRL2_MOUSE Hnrpul2 Manp NM_001081196 Q00PI9 uc008gng.1 uc008gng.2 uc008gng.3 Binds to MLF1 and retains it in the nucleus. Nucleus RNA binding protein binding nucleus nucleoplasm biological_process uc008gng.1 uc008gng.2 uc008gng.3 
ENSMUST00000096766.12 Eml4 ENSMUST00000096766.12 echinoderm microtubule associated protein like 4, transcript variant 7 (from RefSeq NM_001379374.1) ENSMUST00000096766.1 ENSMUST00000096766.10 ENSMUST00000096766.11 ENSMUST00000096766.2 ENSMUST00000096766.3 ENSMUST00000096766.4 ENSMUST00000096766.5 ENSMUST00000096766.6 ENSMUST00000096766.7 ENSMUST00000096766.8 ENSMUST00000096766.9 Eml4 F8WJ93 F8WJ93_MOUSE NM_001379374 uc008drz.1 uc008drz.2 uc008drz.3 uc008drz.4 uc008drz.5 Cytoplasm, cytoskeleton Belongs to the WD repeat EMAP family. uc008drz.1 uc008drz.2 uc008drz.3 uc008drz.4 uc008drz.5 
ENSMUST00000096792.8 Vmn2r129 ENSMUST00000096792.8 vomeronasal 2, receptor, 122, transcript variant 4 (from RefSeq NM_001385247.2) A0A3Q4EIC8 A0A3Q4EIC8_MOUSE ENSMUST00000096792.1 ENSMUST00000096792.2 ENSMUST00000096792.3 ENSMUST00000096792.4 ENSMUST00000096792.5 ENSMUST00000096792.6 ENSMUST00000096792.7 NM_001385247 Vmn2r129 uc290sqw.1 uc290sqw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc290sqw.1 uc290sqw.2 
ENSMUST00000096852.5 Cldn34b1 ENSMUST00000096852.5 claudin 34B1 (from RefSeq NM_001097980.1) B1AZQ8 B1AZQ8_MOUSE Cldn34b1 ENSMUST00000096852.1 ENSMUST00000096852.2 ENSMUST00000096852.3 ENSMUST00000096852.4 NM_001097980 uc012hqy.1 uc012hqy.2 uc012hqy.3 Cell junction, tight junction Belongs to the claudin family. molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc012hqy.1 uc012hqy.2 uc012hqy.3 
ENSMUST00000096862.5 ENSMUSG00000079800 ENSMUST00000096862.5 ENSMUSG00000079800 (from geneSymbol) A530040E14Rik BC096473 ENSMUST00000096862.1 ENSMUST00000096862.2 ENSMUST00000096862.3 ENSMUST00000096862.4 Q3TR44 Q3TR44_MOUSE uc289sox.1 uc289sox.2 uc289sox.1 uc289sox.2 
ENSMUST00000096899.3 BC061237 ENSMUST00000096899.3 cDNA sequence BC061237 (from RefSeq NM_198677.1) BC061237 E9Q2T2 ENSMUST00000096899.1 ENSMUST00000096899.2 Gm3573 NM_198677 Q6P8I2 Q6P8I2_MOUSE uc007tdk.1 uc007tdk.2 molecular_function biological_process uc007tdk.1 uc007tdk.2 
ENSMUST00000096904.6 Reg3b ENSMUST00000096904.6 regenerating islet-derived 3 beta (from RefSeq NM_011036.1) ENSMUST00000096904.1 ENSMUST00000096904.2 ENSMUST00000096904.3 ENSMUST00000096904.4 ENSMUST00000096904.5 NM_011036 P35230 Pap Pap1 REG3B_MOUSE Reg3b uc009cjw.1 uc009cjw.2 uc009cjw.3 Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues. Acts as a hormone in response to different stimuli. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways (PubMed:34099862). In pancreas, is able stimulate cell proliferation (PubMed:34099862). [Regenerating islet-derived protein 3-beta 15 kDa form]: Lipopolysaccharide inhibits pore-forming activity, explaining why is bactericidal for Gram-positive but not Gram-negative bacteria. [Regenerating islet-derived protein 3-beta 15 kDa form]: Forms a hexameric membrane-permeabilizing oligomeric pore on membrane phospholipids. The hexamer is formed by three dimers related by helical symmetry. Forms filaments, filamentation traps pore complexes and limits damage to host cells. Interacts with EXTL3. Secreted Note=Found in the apical region of pancreatic acinar cells. Constitutively expressed in the small intestine, moderately in colon and at an extremely low level in healthy pancreas. Up-regulated in the intestine by S.typhimurium infection (at protein level). Appears in pancreatic juice after induction of pancreatic inflammation. The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity. Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. Note=Overexpressed during the acute phase of pancreatitis. Mice are more susceptible to salmonellosis, but not listeriosis. Name=Functional Glycomics Gateway - Glycan Binding; Note=Pancreatitis-associated protein 1; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_184"; positive regulation of protein phosphorylation transmembrane signaling receptor activity extracellular region extracellular space cytoplasm acute-phase response inflammatory response positive regulation of cell proliferation response to bacterium growth factor binding carbohydrate binding macromolecular complex zymogen granule identical protein binding peptidoglycan binding response to peptide hormone negative regulation of neuron apoptotic process cell wall disruption in other organism apical part of cell defense response to Gram-negative bacterium defense response to Gram-positive bacterium protein homooligomerization negative regulation of cell death oligosaccharide binding negative regulation of hydrogen peroxide-induced neuron death uc009cjw.1 uc009cjw.2 uc009cjw.3 
ENSMUST00000096913.4 Slx ENSMUST00000096913.4 Sycp3 like X-linked (from RefSeq NM_001136476.1) D3Z347 D3Z347_MOUSE ENSMUST00000096913.1 ENSMUST00000096913.2 ENSMUST00000096913.3 NM_001136476 Slx uc012hfm.1 uc012hfm.2 uc012hfm.3 Belongs to the XLR/SYCP3 family. synaptonemal complex XY body nucleus cytoplasm spermatogenesis spermatid development single fertilization sex determination regulation of gene expression spermatid differentiation meiotic cell cycle uc012hfm.1 uc012hfm.2 uc012hfm.3 
ENSMUST00000096953.5 Speer4e2 ENSMUST00000096953.5 spermatogenesis associated glutamate (E)-rich protein 4E2 (from RefSeq NM_001281514.1) ENSMUST00000096953.1 ENSMUST00000096953.2 ENSMUST00000096953.3 ENSMUST00000096953.4 Gm10354 K7N6A0 K7N6A0_MOUSE NM_001281514 uc033iht.1 uc033iht.2 uc033iht.3 molecular_function cellular_component biological_process uc033iht.1 uc033iht.2 uc033iht.3 
ENSMUST00000096987.7 Septin5 ENSMUST00000096987.7 septin 5 (from RefSeq NM_213614.2) B2RUC5 ENSMUST00000096987.1 ENSMUST00000096987.2 ENSMUST00000096987.3 ENSMUST00000096987.4 ENSMUST00000096987.5 ENSMUST00000096987.6 NM_213614 Pnutl1 Q3UYG4 Q6PB74 Q9Z2Q6 SEPT5_MOUSE Sept5 Septin5 uc007yoj.1 uc007yoj.2 uc007yoj.3 Filament-forming cytoskeletal GTPase (By similarity). Involved in cytokinesis (Potential). May play a role in platelet secretion. Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPTIN2 and SEPTIN5. Interaction with SEPTIN4 not detected. In platelets, associated with a complex containing STX4 (By similarity). Interacts with PRKN; this interaction leads to SEPTIN5 ubiquitination and degradation (PubMed:11078524). Interacts with DYRK1A (PubMed:18938227). Interacts with STX1A; in the cerebellar cortex (PubMed:17296554). Q9Z2Q6; O60260: PRKN; Xeno; NbExp=2; IntAct=EBI-772125, EBI-716346; Cytoplasm Cytoplasm, cytoskeleton Detected at 17 dpc in the brain. Expression increases during postnatal life and reaches a plateau at approximately P10 (at protein level). Phosphorylated by DYRK1A. Mice have a normal life-span and show no apparent abnormalities, including synaptic properties and hippocampal neuron growth. In platelets, hyperresponsive degranulation phenotype. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. nucleotide binding stress fiber GTPase activity protein binding GTP binding cytoplasm cytoskeleton plasma membrane cell cortex septin ring cell cycle synaptic vesicle microtubule cytoskeleton regulation of exocytosis GDP binding syntaxin binding adult behavior septin complex cleavage furrow phosphatidylinositol binding social behavior protein homodimerization activity terminal bouton axon terminus calyx of Held synapse positive regulation of exocytosis cell division cytoskeleton-dependent cytokinesis presynapse uc007yoj.1 uc007yoj.2 uc007yoj.3 
ENSMUST00000097014.7 Tuba1a ENSMUST00000097014.7 tubulin, alpha 1A (from RefSeq NM_011653.2) ENSMUST00000097014.1 ENSMUST00000097014.2 ENSMUST00000097014.3 ENSMUST00000097014.4 ENSMUST00000097014.5 ENSMUST00000097014.6 NM_011653 P02551 P05210 P05212 P68369 Q3TGF0 Q3TIW2 Q3TPJ1 Q3ULN1 Q5XJF8 TBA1A_MOUSE Tuba1 uc007xok.1 uc007xok.2 uc007xok.3 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. P68369; Q80TQ2: Cyld; NbExp=5; IntAct=EBI-400542, EBI-943859; Cytoplasm, cytoskeleton. Ubiquitously expressed, although primarily in lung and brain. Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility (PubMed:33414192). Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:1967194, PubMed:15890843). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (PubMed:23897886). Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly. Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability. Nitration of Tyr-451 is irreversible and interferes with normal dynein intracellular distribution. Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (MATCAP, VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively. [Tubulin alpha-1A chain]: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (PubMed:16954346, PubMed:19564401). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules. In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity). [Detyrosinated tubulin alpha-1A chain]: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (By similarity). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle (PubMed:26446751). In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (PubMed:27102488). Belongs to the tubulin family. nucleotide binding microtubule cytoskeleton organization mitotic cell cycle GTPase activity structural constituent of cytoskeleton protein binding GTP binding cytoplasm cytoskeleton microtubule cytoplasmic microtubule microtubule-based process microtubule cytoskeleton protein domain specific binding neuromuscular junction cytoplasmic ribonucleoprotein granule myelin sheath membrane raft regulation of synapse organization recycling endosome uc007xok.1 uc007xok.2 uc007xok.3 
ENSMUST00000097029.4 Fthl17f ENSMUST00000097029.4 ferritin, heavy polypeptide-like 17, member F (from RefSeq NM_001038697.2) EG434729 ENSMUST00000097029.1 ENSMUST00000097029.2 ENSMUST00000097029.3 Fthl17f Gm5635 NM_001038697 Q3SXD2 Q3SXD2_MOUSE uc009spn.1 uc009spn.2 uc009spn.3 Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. ferroxidase activity iron ion binding cytoplasm iron ion transport cellular iron ion homeostasis intracellular sequestering of iron ion ferrous iron binding ferric iron binding identical protein binding metal ion binding oxidation-reduction process uc009spn.1 uc009spn.2 uc009spn.3 
ENSMUST00000097080.4 C2cd6 ENSMUST00000097080.4 C2 calcium dependent domain containing 6, transcript variant 2 (from RefSeq NM_175200.4) A0A5F8MPU3 Als2cr11 C2cd6 CATSPERT CTSRT_MOUSE E9Q152 ENSMUST00000097080.1 ENSMUST00000097080.2 ENSMUST00000097080.3 NM_175200 uc007bdc.1 uc007bdc.2 Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CatSper complex targeting and trafficking into the quadrilinear nanodomains. Targets the preassembled CatSper complexes to elongating flagella, where it links the channel- carrying vesicles and motor proteins. Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG, CATSPERD, CATSPERE, CATSPERZ, C2CD6/CATSPERT, SLCO6C1, TMEM249, TMEM262 and EFCAB9. HSPA1 may be an additional auxiliary complex member. The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel. The auxiliary CATSPERB, CATSPERG, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively. SLCO6C1 interacts with CATSPERE and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex. C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane. Cell projection, cilium, flagellum membrane Note=Specifically located in the principal piece of the sperm tail. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=L ; IsoId=A0A5F8MPU3-1; Sequence=Displayed; Name=2; Synonyms=S ; IsoId=A0A5F8MPU3-2; Sequence=VSP_061603, VSP_061604; [Isoform 1]: Expressed in cauda sperm (at protein level). [Isoform 2]: Expressed in cauda sperm (at protein level). Mutant mice have no gross abnormality in survival, appearance or behavior. Males are infertile with defective sperm hyperactivation. Females have normal reproductive ability and give birth with no difference in litter size. uc007bdc.1 uc007bdc.2 
ENSMUST00000097177.5 Psmb11 ENSMUST00000097177.5 proteasome (prosome, macropain) subunit, beta type, 11 (from RefSeq NM_175204.4) ENSMUST00000097177.1 ENSMUST00000097177.2 ENSMUST00000097177.3 ENSMUST00000097177.4 NM_175204 PSB11_MOUSE Q149K8 Q8BG41 uc007twn.1 uc007twn.2 uc007twn.3 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T-cells. Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Incorporated instead of PSMB5 and PSMB8. Cytoplasm Nucleus Expressed exclusively in cortical thymic epithelial cells. Displays defective development of CD8-positive T- cells in the thymus. Belongs to the peptidase T1B family. proteasome complex endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteolysis peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, beta-subunit complex proteasome-mediated ubiquitin-dependent protein catabolic process CD8-positive, alpha-beta T cell differentiation proteolysis involved in cellular protein catabolic process uc007twn.1 uc007twn.2 uc007twn.3 
ENSMUST00000097218.7 Rnf26rt ENSMUST00000097218.7 Rnf26rt (from geneSymbol) AK207867 E9PVG0 E9PVG0_MOUSE ENSMUST00000097218.1 ENSMUST00000097218.2 ENSMUST00000097218.3 ENSMUST00000097218.4 ENSMUST00000097218.5 ENSMUST00000097218.6 Gm9008 Rnf26rt uc291fxp.1 uc291fxp.2 membrane integral component of membrane uc291fxp.1 uc291fxp.2 
ENSMUST00000097237.4 Gm23741 ENSMUST00000097237.4 Gm23741 (from geneSymbol) ENSMUST00000097237.1 ENSMUST00000097237.2 ENSMUST00000097237.3 uc291krr.1 uc291krr.2 uc291krr.1 uc291krr.2 
ENSMUST00000097244.3 Gm23254 ENSMUST00000097244.3 Gm23254 (from geneSymbol) ENSMUST00000097244.1 ENSMUST00000097244.2 uc291qpz.1 uc291qpz.2 uc291qpz.1 uc291qpz.2 
ENSMUST00000097257.3 Gm26467 ENSMUST00000097257.3 Gm26467 (from geneSymbol) ENSMUST00000097257.1 ENSMUST00000097257.2 uc291qrs.1 uc291qrs.2 uc291qrs.1 uc291qrs.2 
ENSMUST00000097271.4 Irgm1 ENSMUST00000097271.4 immunity-related GTPase family M member 1, transcript variant 2 (from RefSeq NM_001355757.1) ENSMUST00000097271.1 ENSMUST00000097271.2 ENSMUST00000097271.3 IRGM1_MOUSE Ifi1 Iigp3 Irgm Irgm1 NM_001355757 Q3TJ73 Q60766 uc287xro.1 uc287xro.2 Immunity-related GTPase that plays important roles in innate immunity and inflammatory response (PubMed:11457893, PubMed:14576437, PubMed:14707092, PubMed:15908352, PubMed:16339555, PubMed:17911638, PubMed:17982087, PubMed:19620982, PubMed:19920210). Acts as a dynamin- like protein that binds to intracellular membranes and promotes remodeling and trafficking of those membranes (PubMed:19620982, PubMed:27098192). Required for clearance of acute protozoan and bacterial infections by interacting with autophagy and lysosome regulatory proteins, thereby promoting the fusion of phagosomes with lysosomes for efficient degradation of cargo including microbes (PubMed:11457893, PubMed:14576437, PubMed:15607973, PubMed:14707092, PubMed:15908352, PubMed:16339555, PubMed:17982087, PubMed:19620982, PubMed:19920210, PubMed:24751652, PubMed:21757726, PubMed:22874556, PubMed:32453761). Regulates selective autophagy, including xenophagy and mitophagy, both directly and indirectly (PubMed:15607973, PubMed:21757726). Directly regulates autophagy by acting as a molecular adapter that promotes the coassembly of the core autophagy machinery to mediate antimicrobial defense: Irgm1 (1) activates AMPK, which in turn phosphorylates ULK1 and BECN1 to induce autophagy, (2) promotes the coassembly of ULK1 and BECN1, enhancing BECN1-interacting partners and (3) influences the composition of the BECN1 complex, by competing with the negative regulators BCL2 and RUBCN, to trigger autophagy (By similarity). Also activates autophagy by promoting recruitment of STX17 to autophagosomes (By similarity). In collaboration with ATG8 proteins, regulate lysosomal biogenesis, a fundamental process for any autophagic pathway, by promoting TFEB dephosphorylation (By similarity). Also modulates autophagy by assisting with autophagosome formation and preventing lysosomal deacidification (PubMed:21757726). Regulates autophagy by affecting mitochondrial fusion and fission (PubMed:24751652). Also involved in M1 macrophage activation for the production of proinflammatory cytokines (PubMed:15908352, PubMed:27439214, PubMed:27443879). While activating autophagy, acts as a key negative regulator of the inflammatory and interferon responses both by (1) promoting mitophagy and (2) mediating autophagy-dependent degradation of effectors of the inflammatory response (PubMed:30612879, PubMed:34467632, PubMed:33510463). Promotes degradation of damaged and IFNG/IFN-gamma-stressed mitochondria via mitophagy, preventing cytosolic release of ligands that activate inflammation (PubMed:32715615, PubMed:33510463). Negatively regulates interferon- signaling in hematopoietic stem cells, preserving hematopoietic stem cell number and function (PubMed:18371424, PubMed:21633090). Promotes expansion of activated CD4(+) T-cells by inhibiting IFNG/IFN-gamma signaling, thereby preventing Ifng-mediated cell death of CD4(+) T- cells (PubMed:18806793). Acts as a suppressor of inflammation by promoting recruitment of inflammation effectors, such as CGAS, RIGI/RIG-I and NLRP3, to autophagosome membranes, leading to their SQSTM1/p62-dependent autophagic degradation (By similarity). Also directly inhibits assembly of the NLRP3 inflammasome by preventing the association between NLRP3 and PYCARD (By similarity). Acts as a negative regulator of antiviral innate immune response by suppressing the RIPK2-dependent pro-inflammatory response: mediates recruitment of RIPosomes, composed of RIPK2 and NOD1 or NOD2, to autophagosome membranes, promoting their SQSTM1/p62-dependent autophagic degradation (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Interacts with ULK1; promoting the coassembly of ULK1 and BECN1. Interacts with BECN1; enhancing BECN1-interacting partners and influencing the composition of the BECN1 complex. Interacts with ATG16L1. Interacts with NOD2; promoting Irgm1 'Lys-63'-linked polyubiquitination, which is required for interactions with the core autophagy factors (By similarity). Interacts with STX17; promoting STX17 recruitment to autophagosomes (By similarity). Interacts with ATG8 proteins (GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C); promoting STX17 recruitment to autophagosomes (By similarity). Interacts with TFEB; promoting association between TFEB and PPP3CB and TFEB dephosphorylation (By similarity). Interacts with PPP3CB; promoting association between TFEB and PPP3CB and TFEB dephosphorylation (By similarity). Interacts with NLRP3; preventing NLRP3 inflammasome assembly and promoting SQSTM1/p62-dependent autophagic degradation of NLRP3 (By similarity). Interacts with CGAS; promoting SQSTM1/p62-dependent autophagic degradation of CGAS (By similarity). Interacts with RIGI/RIG-I; promoting SQSTM1/p62-dependent autophagic degradation of RIGI/RIG-I (By similarity). Interacts with NOD1; promoting SQSTM1/p62-dependent autophagic degradation of RIGI/RIG-I (By similarity). Interacts with NOD2; promoting SQSTM1/p62- dependent autophagic degradation of RIGI/RIG-I (By similarity). Interacts with RIPK2; promoting SQSTM1/p62-dependent autophagic degradation of RIGI/RIG-I (By similarity). Interacts with PIK3CA (PubMed:19620982). Golgi apparatus membrane ll membrane Cytoplasmic vesicle, phagosome membrane Cytoplasmic vesicle, autophagosome membrane Lysosome membrane te endosome membrane Mitochondrion membrane Lipid droplet Cell projection, phagocytic cup Note=Behaves like an integral membrane protein (PubMed:15294976). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing phagosomes (PubMed:15294976). Association with phagosomes is dependent on nucleotide-binding but is IFNG-independent (PubMed:15294976). Also detected in late endosomes and lysosomes: lysosomal localization is IFN-gamma-induced during bacterial infections such as S.typhimurium infection (PubMed:17982087, PubMed:20072621). Associates with lipid droplets and 'self' cytoplasmic vacuoles, while it does not coat 'non- self' pathogen-containing vacuoles (PubMed:23785284). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60766-1; Sequence=Displayed; Name=2; IsoId=Q60766-2; Sequence=VSP_032384; Expressed in lung and primary macrophages. Up-regulated by LPS and IFNG (at protein level) (PubMed:7561525, PubMed:11457893, PubMed:14576437, PubMed:15294976, PubMed:17911638). Up-regulated upon infection by various pathogens including T.cruzi, T.gondii, L.monocytogenes, M.tuberculosis and murine cytomegalovirus (PubMed:14707092, PubMed:16339555). The alpha-K amphipathic helix mediates targeting to the phagosome membrane via binding to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3). Palmitoylated on C-terminal Cys residues (PubMed:24751652). Palmitoylation, together with the alpha-K amphipathic helix, which binds phosphatidylinositol, mediate binding to membranes (PubMed:24751652). Ubiquitinated via 'Lys-63'-linked polyubiquitination in a NOD2- dependent process. 'Lys-63'-linked polyubiquitination is required for interactions with the core autophagy factors (By similarity). Ubiquitination at Lys-270 by the DCX(WDR77) complex, also named CLR4(WDR77) complex, in intestinal cells, leading to its degradation by the proteasome (PubMed:35197566). Mice do not show obvious abnormalities, but are more susceptible to infection by S.typhimurium, T.cruzi, T.gondii, L.monocytogenes, C.rodentium and M.tuberculosis (PubMed:11457893, PubMed:14576437, PubMed:32453761). Upon infection, alterations of blood elements occur including lymphopenia, anemia, and thrombocytopenia (PubMed:11457893, PubMed:14576437, PubMed:18371424). Mice become anemic and neutropenic as a result of chronic infection, and their hematopoietic stem cells are defective in the ability to reconstitute the blood of a Bone marrow-depleted host (PubMed:18371424). Mice display impaired expansion of activated CD4(+) T-cell population: defects are caused by Infg-mediated cell death of CD4(+) T-cells (PubMed:18806793). Mice also show increased inflammation with autoimmune features (PubMed:28154172, PubMed:28814662, PubMed:30612879, PubMed:32715615, PubMed:33510463). Macrophages show an increased production of proinflammatory cytokines associated with marked metabolic changes, characterized by increased glycolysis and an accumulation of long chain acylcarnitines (PubMed:28154172). Mice display autoimmune disorder reminiscent of Sjogren's syndrome, characterized by up-regulation of type I interferons (PubMed:28814662). Type I interferonopathy, characterized by up-regulation of type I interferons, is caused by activation of inflammation effectors, such as CGAS and NLRP3 (PubMed:30612879, PubMed:32715615, PubMed:33510463). Mice show an increased antiviral innate immune response and are highly resistant to chikungunya virus (CHIKV) infection (PubMed:34467632). Mice lacking both Irgm1 and Igtp/Irgm3 display resistance to Mycobacterium tuberculosis infection compared to Irgm1 mice that are highly susceptible to infection (PubMed:36629440). Mice lacking Irgm1, Irgm2 and Igtp/Irgm3 (panIrgm mice) show resistance against M.tuberculosis one month post-infection; then, panIrgm mice display higher bacterial burden and altered cytokine during late stage of infection, leading to increased mortality (PubMed:36629440). Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. autophagosome assembly Golgi membrane nucleotide binding autophagosome membrane phagocytic cup immune system process GTPase activity GTP binding lysosome lysosomal membrane endosome late endosome autophagosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane autophagy defense response response to bacterium membrane hydrolase activity phagocytic vesicle membrane cytoplasmic vesicle late endosome membrane cellular response to interferon-beta cell projection autolysosome innate immune response phagocytic vesicle positive regulation of interferon-gamma-mediated signaling pathway cellular response to interferon-gamma autophagy of host cells involved in interaction with symbiont positive regulation of autophagosome maturation uc287xro.1 uc287xro.2 
ENSMUST00000097275.9 Prkce ENSMUST00000097275.9 protein kinase C, epsilon (from RefSeq NM_011104.3) ENSMUST00000097275.1 ENSMUST00000097275.2 ENSMUST00000097275.3 ENSMUST00000097275.4 ENSMUST00000097275.5 ENSMUST00000097275.6 ENSMUST00000097275.7 ENSMUST00000097275.8 KPCE_MOUSE NM_011104 P16054 Pkce Pkcea uc008dug.1 uc008dug.2 uc008dug.3 Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell- cell detachment prior to migration. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin- induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma- aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-566 (activation loop of the kinase domain), Thr-710 (turn motif) and Ser-729 (hydrophobic region), need to be phosphorylated for its full activation. Forms a ternary complex with TRIM63 and RACK1/GN2BL1 (By similarity). Can form a complex with PDLIM5 and N-type calcium channel (By similarity). Interacts with COPB1 (By similarity). Interacts with DGKQ (By similarity). Interacts with STAT3 (By similarity). Interacts with YWHAB (PubMed:18604201). Interacts with HSP90AB1; promotes functional activation in a heat shock-dependent manner (By similarity). Interacts (via phorbol-ester/DAG-type 2 domain) with PRPH and VIM (By similarity). Interacts with NLRP5/MATER (By similarity). P16054; P23242: Gja1; NbExp=3; IntAct=EBI-298451, EBI-298630; P16054; Q9CQV8: Ywhab; NbExp=5; IntAct=EBI-298451, EBI-771608; Cytoplasm Cytoplasm, cytoskeleton Cell membrane Cytoplasm, perinuclear region Nucleus Note=Translocated to plasma membrane in epithelial cells stimulated by HGF (By similarity). Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (PubMed:17611075). In passaging cells, translocated to the cell periphery (PubMed:17611075). Translocated to the nucleus in PMA-treated cells (PubMed:17611075). The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain. Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729 (By similarity). Phosphorylation in the hinge domain at Ser- 350 by MAPK11 or MAPK14, Ser-346 by GSK3B and Ser-368 by autophosphorylation is required for interaction with YWHAB. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. Golgi membrane nucleotide binding macrophage activation involved in immune response immune system process actin monomer binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-independent protein kinase C activity receptor binding protein binding ATP binding nucleus cytoplasm mitochondrion endoplasmic reticulum cytosol cytoskeleton plasma membrane protein phosphorylation cell cycle cell adhesion chemosensory behavior enzyme activator activity positive regulation of epithelial cell migration positive regulation of fibroblast migration positive regulation of cell-substrate adhesion negative regulation of mitochondrial membrane potential membrane kinase activity phosphorylation transferase activity SH3 domain binding peptidyl-serine phosphorylation regulation of lipid metabolic process enzyme binding protein kinase binding T-tubule receptor activator activity positive regulation of actin filament polymerization negative regulation of protein ubiquitination neuromuscular junction lipopolysaccharide-mediated signaling pathway positive regulation of insulin secretion positive regulation of synaptic transmission, GABAergic positive regulation of cytokinesis ethanol binding intracellular signal transduction locomotory exploration behavior TRAM-dependent toll-like receptor 4 signaling pathway cellular response to platelet-derived growth factor stimulus negative regulation of apoptotic process positive regulation of catalytic activity positive regulation of I-kappaB kinase/NF-kappaB signaling response to morphine positive regulation of MAPK cascade metal ion binding perinuclear region of cytoplasm regulation of peptidyl-tyrosine phosphorylation positive regulation of lipid catabolic process regulation of release of sequestered calcium ion into cytosol negative regulation of release of sequestered calcium ion into cytosol cell division negative regulation of mitochondrial calcium ion concentration regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of mucus secretion cellular response to ethanol cellular response to prostaglandin E stimulus cellular response to hypoxia 14-3-3 protein binding cell periphery positive regulation of wound healing glutamatergic synapse presynaptic cytosol regulation of synaptic vesicle exocytosis positive regulation of cellular glucuronidation Golgi apparatus uc008dug.1 uc008dug.2 uc008dug.3 
ENSMUST00000097281.4 Heatr5b ENSMUST00000097281.4 HEAT repeat containing 5B (from RefSeq NM_001081179.1) ENSMUST00000097281.1 ENSMUST00000097281.2 ENSMUST00000097281.3 HTR5B_MOUSE Kiaa1414 NM_001081179 Q3TPS4 Q5DTY0 Q5PRF1 Q8C547 Q8C6W1 Q8C773 uc008dpc.1 uc008dpc.2 uc008dpc.3 Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity). Self-associates (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, at least composed of AFTPH/aftiphilin, HEATR5B/p200a and SYNRG/gamma-synergin, which plays a role in the AP1G1/AP-1-mediated protein trafficking from early to recycling endosomes and between the trans-Golgi network (TGN) and endosomes (By similarity). Within the complex interacts with AFTPH/aftiphilin and SYNRG/gamma-synergin; the interactions are direct (By similarity). Interacts with GGA1 (By similarity). Cytoplasm, perinuclear region Cytoplasmic vesicle, clathrin-coated vesicle Note=Localization at clathrin- coated vesicles depends on AFTPH/aftiphilin. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8C547-1; Sequence=Displayed; Name=2; IsoId=Q8C547-2; Sequence=VSP_029696; Name=3; IsoId=Q8C547-3; Sequence=VSP_029694, VSP_029695; Name=4; IsoId=Q8C547-4; Sequence=VSP_029693; Belongs to the HEATR5 family. Sequence=BAC35246.1; Type=Frameshift; Evidence=; Sequence=BAD90444.1; Type=Erroneous translation; Evidence=; Sequence=BAD90444.1; Type=Frameshift; Evidence=; Sequence=BAE37661.1; Type=Erroneous initiation; Evidence=; protein binding cytosol endocytosis protein localization endocytic vesicle retrograde transport, endosome to Golgi uc008dpc.1 uc008dpc.2 uc008dpc.3 
ENSMUST00000097284.10 Togaram2 ENSMUST00000097284.10 TOG array regulator of axonemal microtubules 2 (from RefSeq NM_177087.4) ENSMUST00000097284.1 ENSMUST00000097284.2 ENSMUST00000097284.3 ENSMUST00000097284.4 ENSMUST00000097284.5 ENSMUST00000097284.6 ENSMUST00000097284.7 ENSMUST00000097284.8 ENSMUST00000097284.9 Fam179a NM_177087 Q3TYG6 Q8C7B2 TGRM2_MOUSE uc008dmt.1 uc008dmt.2 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TYG6-1; Sequence=Displayed; Name=2; IsoId=Q3TYG6-2; Sequence=VSP_032496, VSP_032497; Belongs to the Crescerin family. molecular_function cellular_component biological_process uc008dmt.1 uc008dmt.2 
ENSMUST00000097290.4 Lrrc30 ENSMUST00000097290.4 leucine rich repeat containing 30 (from RefSeq NM_001033340.3) B2RVX0 B2RVX0_MOUSE ENSMUST00000097290.1 ENSMUST00000097290.2 ENSMUST00000097290.3 Lrrc30 NM_001033340 uc008dkf.1 uc008dkf.2 uc008dkf.3 uc008dkf.1 uc008dkf.2 uc008dkf.3 
ENSMUST00000097295.11 AU016765 ENSMUST00000097295.11 expressed sequence AU016765 (from RefSeq NR_045899.1) ENSMUST00000097295.1 ENSMUST00000097295.10 ENSMUST00000097295.2 ENSMUST00000097295.3 ENSMUST00000097295.4 ENSMUST00000097295.5 ENSMUST00000097295.6 ENSMUST00000097295.7 ENSMUST00000097295.8 ENSMUST00000097295.9 NR_045899 uc008dfx.1 uc008dfx.2 uc008dfx.3 uc008dfx.4 uc008dfx.5 uc008dfx.1 uc008dfx.2 uc008dfx.3 uc008dfx.4 uc008dfx.5 
ENSMUST00000097303.3 Arrdc5 ENSMUST00000097303.3 arrestin domain containing 5 (from RefSeq NM_029799.2) ARRD5_MOUSE ENSMUST00000097303.1 ENSMUST00000097303.2 NM_029799 Q497K5 uc008dbo.1 uc008dbo.2 Belongs to the arrestin family. molecular_function cellular_component biological_process uc008dbo.1 uc008dbo.2 
ENSMUST00000097311.9 Foxp4 ENSMUST00000097311.9 forkhead box P4, transcript variant 5 (from RefSeq NM_001403970.1) A0A0R4J161 A0A0R4J161_MOUSE ENSMUST00000097311.1 ENSMUST00000097311.2 ENSMUST00000097311.3 ENSMUST00000097311.4 ENSMUST00000097311.5 ENSMUST00000097311.6 ENSMUST00000097311.7 ENSMUST00000097311.8 Foxp4 NM_001403970 uc008cwm.1 uc008cwm.2 uc008cwm.3 uc008cwm.4 Nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc008cwm.1 uc008cwm.2 uc008cwm.3 uc008cwm.4 
ENSMUST00000097317.10 Slc29a1 ENSMUST00000097317.10 solute carrier family 29 (nucleoside transporters), member 1, transcript variant 3 (from RefSeq NM_001199114.2) ENSMUST00000097317.1 ENSMUST00000097317.2 ENSMUST00000097317.3 ENSMUST00000097317.4 ENSMUST00000097317.5 ENSMUST00000097317.6 ENSMUST00000097317.7 ENSMUST00000097317.8 ENSMUST00000097317.9 Ent1 NM_001199114 Q99K84 Q9DBT8 Q9JHF0 Q9JIM1 S29A1_MOUSE Slc29a1 uc012aue.1 uc012aue.2 uc012aue.3 Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:11085929, PubMed:35790189). Functions as a Na(+)-independent transporter (By similarity). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:11085929, PubMed:35790189, PubMed:23639800). Also transports purine (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (By similarity). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood- testis-barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189). Reaction=adenosine(in) = adenosine(out); Xref=Rhea:RHEA:75343, ChEBI:CHEBI:16335; Evidence=; Reaction=guanosine(in) = guanosine(out); Xref=Rhea:RHEA:75371, ChEBI:CHEBI:16750; Evidence=; Reaction=inosine(in) = inosine(out); Xref=Rhea:RHEA:75375, ChEBI:CHEBI:17596; Evidence=; Reaction=uridine(out) = uridine(in); Xref=Rhea:RHEA:71519, ChEBI:CHEBI:16704; Evidence=; Reaction=thymidine(in) = thymidine(out); Xref=Rhea:RHEA:75363, ChEBI:CHEBI:17748; Evidence=; Reaction=cytidine(in) = cytidine(out); Xref=Rhea:RHEA:75367, ChEBI:CHEBI:17562; Evidence=; Reaction=adenine(out) = adenine(in); Xref=Rhea:RHEA:71523, ChEBI:CHEBI:16708; Evidence=; Reaction=guanine(out) = guanine(in); Xref=Rhea:RHEA:71531, ChEBI:CHEBI:16235; Evidence=; Reaction=thymine(out) = thymine(in); Xref=Rhea:RHEA:71527, ChEBI:CHEBI:17821; Evidence=; Reaction=uracil(in) = uracil(out); Xref=Rhea:RHEA:69404, ChEBI:CHEBI:17568; Evidence=; Reaction=hypoxanthine(out) = hypoxanthine(in); Xref=Rhea:RHEA:71515, ChEBI:CHEBI:17368; Evidence=; Transporter activity is sensitive to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR). Identified in a complex with STOM. Basolateral cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Ent1b; IsoId=Q9JIM1-1; Sequence=Displayed; Name=2; IsoId=Q9JIM1-2; Sequence=VSP_010471; Highly expressed in heart, spleen, lung, liver and testis. Lower level of expression in brain and kidney (PubMed:11027664). Expressed in adipose tissues, brown adipocytes expressing significantly higher amounts than white adipocytes (PubMed:35790189). Expressed in seminiferous tubules (PubMed:23639800). Cys-418 near TM10 is a major determinant of nucleobase transport activity. Glycosylated. Knockout mice show an increase in extracellular inosine levels and consequently enhancement differentiation and thermogenic capacity of brown adipocytes (PubMed:35790189). Knockout mice show an increased brown adipocyte tissue function and browning of white adipocyte tissue, and are resistant to diet-induced obesity (PubMed:35790189). Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. nucleoside transmembrane transporter activity plasma membrane integral component of plasma membrane lactation nucleoside transport uridine transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane sleep excitatory postsynaptic potential cellular response to glucose stimulus cellular response to hypoxia presynapse postsynapse neurotransmitter reuptake nucleoside transmembrane transport uc012aue.1 uc012aue.2 uc012aue.3 
ENSMUST00000097324.4 Esp6 ENSMUST00000097324.4 exocrine gland secreted peptide 6 (from RefSeq NM_001177529.1) A8R0U0 A8R0U0_MOUSE ENSMUST00000097324.1 ENSMUST00000097324.2 ENSMUST00000097324.3 Esp6 NM_001177529 uc012atj.1 uc012atj.2 uc012atj.3 uc012atj.4 pheromone activity extracellular space biological_process uc012atj.1 uc012atj.2 uc012atj.3 uc012atj.4 
ENSMUST00000097331.2 Gm6034 ENSMUST00000097331.2 predicted gene 6034 (from RefSeq NR_177944.1) ENSMUST00000097331.1 NR_177944 uc008cjy.1 uc008cjy.2 uc008cjy.1 uc008cjy.2 
ENSMUST00000097336.5 Lst1 ENSMUST00000097336.5 leukocyte specific transcript 1 (from RefSeq NM_010734.2) B8JJ61 B8JJ61_MOUSE ENSMUST00000097336.1 ENSMUST00000097336.2 ENSMUST00000097336.3 ENSMUST00000097336.4 Lst1 NM_010734 uc008cgn.1 uc008cgn.2 uc008cgn.3 cell morphogenesis immune response membrane integral component of membrane uc008cgn.1 uc008cgn.2 uc008cgn.3 
ENSMUST00000097338.11 Msh5 ENSMUST00000097338.11 mutS homolog 5, transcript variant 2 (from RefSeq NM_001146215.2) A0A0R4IZY8 A0A0R4IZY8_MOUSE ENSMUST00000097338.1 ENSMUST00000097338.10 ENSMUST00000097338.2 ENSMUST00000097338.3 ENSMUST00000097338.4 ENSMUST00000097338.5 ENSMUST00000097338.6 ENSMUST00000097338.7 ENSMUST00000097338.8 ENSMUST00000097338.9 Msh5 NM_001146215 uc008cfd.1 uc008cfd.2 uc008cfd.3 uc008cfd.4 uc008cfd.5 This gene encodes a member of the MutS family of proteins that play critical roles in DNA mismatch repair and meiotic homologous recombination processes. Mice lacking the encoded protein are viable but sterile, with severe defects in spermatogenesis in males and complete loss of ovarian structures in females. Mutations in a similar gene in humans have been shown to cause common variable immune deficiency (CVID) and immunoglobulin A deficiency. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. Belongs to the DNA mismatch repair MutS family. ATP binding mismatch repair mismatched DNA binding uc008cfd.1 uc008cfd.2 uc008cfd.3 uc008cfd.4 uc008cfd.5 
ENSMUST00000097343.11 Nelfe ENSMUST00000097343.11 negative elongation factor complex member E, Rdbp, transcript variant 3 (from RefSeq NM_001045864.1) ENSMUST00000097343.1 ENSMUST00000097343.10 ENSMUST00000097343.2 ENSMUST00000097343.3 ENSMUST00000097343.4 ENSMUST00000097343.5 ENSMUST00000097343.6 ENSMUST00000097343.7 ENSMUST00000097343.8 ENSMUST00000097343.9 NM_001045864 Nelfe Q3UIA1 Q3UIA1_MOUSE Rdbp uc008cdx.1 uc008cdx.2 uc008cdx.3 Chromosome Nucleus Belongs to the RRM NELF-E family. negative regulation of transcription from RNA polymerase II promoter nucleic acid binding chromatin binding RNA binding nucleus nucleoplasm plasma membrane regulation of transcription, DNA-templated nuclear body NELF complex positive regulation of transcription from RNA polymerase II promoter positive regulation of histone H3-K4 methylation positive regulation of ERK1 and ERK2 cascade negative regulation of mRNA polyadenylation uc008cdx.1 uc008cdx.2 uc008cdx.3 
ENSMUST00000097352.11 Pknox1 ENSMUST00000097352.11 Pbx/knotted 1 homeobox, transcript variant 1 (from RefSeq NM_016670.4) ENSMUST00000097352.1 ENSMUST00000097352.10 ENSMUST00000097352.2 ENSMUST00000097352.3 ENSMUST00000097352.4 ENSMUST00000097352.5 ENSMUST00000097352.6 ENSMUST00000097352.7 ENSMUST00000097352.8 ENSMUST00000097352.9 NM_016670 O70477 PKNX1_MOUSE Pknox1 Prep1 Q7TT01 uc008bvi.1 uc008bvi.2 uc008bvi.3 uc008bvi.4 uc008bvi.5 Activates transcription in the presence of PBX1A and HOXA1. (Microbial infection) In complex with PBX1, binds to the 5'- TGATTGAC-3' consensus sequence in the U5 region of Moloney murine leukemia virus and promotes viral transcription. Interacts with MN1. Nucleus Belongs to the TALE/MEIS homeobox family. Sequence=AAC15990.1; Type=Erroneous initiation; Evidence=; RNA polymerase II transcription factor activity, sequence-specific DNA binding angiogenesis DNA binding chromatin binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter hemopoiesis T cell differentiation erythrocyte differentiation camera-type eye development sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity uc008bvi.1 uc008bvi.2 uc008bvi.3 uc008bvi.4 uc008bvi.5 
ENSMUST00000097355.5 4930403O15Rik ENSMUST00000097355.5 4930403O15Rik (from geneSymbol) AK015069 ENSMUST00000097355.1 ENSMUST00000097355.2 ENSMUST00000097355.3 ENSMUST00000097355.4 uc287pxf.1 uc287pxf.2 uc287pxf.3 uc287pxf.1 uc287pxf.2 uc287pxf.3 
ENSMUST00000097381.5 Vmn2r112 ENSMUST00000097381.5 vomeronasal 2, receptor 112 (from RefSeq NM_001104575.1) ENSMUST00000097381.1 ENSMUST00000097381.2 ENSMUST00000097381.3 ENSMUST00000097381.4 L7N221 L7N221_MOUSE NM_001104575 Vmn2r112 uc009vbp.1 uc009vbp.2 uc009vbp.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vbp.1 uc009vbp.2 uc009vbp.3 
ENSMUST00000097393.11 Ermard ENSMUST00000097393.11 ER membrane associated RNA degradation, transcript variant 6 (from RefSeq NM_001405474.2) E9Q048 E9Q048_MOUSE ENSMUST00000097393.1 ENSMUST00000097393.10 ENSMUST00000097393.2 ENSMUST00000097393.3 ENSMUST00000097393.4 ENSMUST00000097393.5 ENSMUST00000097393.6 ENSMUST00000097393.7 ENSMUST00000097393.8 ENSMUST00000097393.9 Ermard NM_001405474 uc012akr.1 uc012akr.2 uc012akr.3 molecular_function cellular_component biological_process uc012akr.1 uc012akr.2 uc012akr.3 
ENSMUST00000097395.5 Ermardl1 ENSMUST00000097395.5 ER membrane associated RNA degradation like 1 (from RefSeq NM_001123372.1) ENSMUST00000097395.1 ENSMUST00000097395.2 ENSMUST00000097395.3 ENSMUST00000097395.4 Ermardl1 F6UWZ4 F6UWZ4_MOUSE Gm3435 NM_001123372 uc012akq.1 uc012akq.2 uc012akq.3 molecular_function cellular_component biological_process uc012akq.1 uc012akq.2 uc012akq.3 
ENSMUST00000097399.6 Dynlt2a3 ENSMUST00000097399.6 dynein light chain Tctex-type 2A3, transcript variant 1 (from RefSeq NM_001123368.1) DYLT2_MOUSE Dynlt2 ENSMUST00000097399.1 ENSMUST00000097399.2 ENSMUST00000097399.3 ENSMUST00000097399.4 ENSMUST00000097399.5 NM_001123368 P11985 P51806 Q66L72 Q7TN76 Q9D9X4 Tcte3 Tctex1d3 Tctex2 Tctex4 uc008anl.1 uc008anl.2 uc008anl.3 uc008anl.4 This gene is one of three genes with a very high degree of similarity to each other within a 77 kb genomic span on Chromosome 17 A2. This gene is the most proximal copy of the three genes. [provided by RefSeq, Jul 2008]. May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility. Interacts with CSNK2B. P11985-2; P67871: Csnk2b; NbExp=2; IntAct=EBI-1781298, EBI-348179; Cytoplasm, cytoskeleton Cytoplasmic granule Membrane ; Peripheral membrane protein Note=Found on the surface of sperm tail. Stored in cytoplasmic granules during spermatogenesis. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=P11985-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P11985-2; Sequence=VSP_004449; Expressed in testis (at protein level). Expressed at the pachyten stage of the first meiotic division and in later haploid spermatogenic stages. Note=Could be involved in transmission ratio distortion (trd) in mouse t-haplotype which causes male sterility. Belongs to the dynein light chain Tctex-type family. motor activity protein binding cytoplasm cytoskeleton cytoplasmic dynein complex microtubule microtubule-based movement membrane extrinsic component of membrane dynein complex sperm flagellum uc008anl.1 uc008anl.2 uc008anl.3 uc008anl.4 
ENSMUST00000097403.4 Tcp10c ENSMUST00000097403.4 t-complex protein 10c (from RefSeq NM_001167578.1) E9Q046 E9Q046_MOUSE ENSMUST00000097403.1 ENSMUST00000097403.2 ENSMUST00000097403.3 Gm9880 NM_001167578 Tcp10c uc008amg.1 uc008amg.2 uc008amg.3 Belongs to the TCP10 family. transcription corepressor activity nucleus centriole biological_process negative regulation of nucleic acid-templated transcription uc008amg.1 uc008amg.2 uc008amg.3 
ENSMUST00000097419.10 Cep43 ENSMUST00000097419.10 centrosomal protein 43, transcript variant 1 (from RefSeq NM_001197046.1) CEP43_MOUSE Cep43 ENSMUST00000097419.1 ENSMUST00000097419.2 ENSMUST00000097419.3 ENSMUST00000097419.4 ENSMUST00000097419.5 ENSMUST00000097419.6 ENSMUST00000097419.7 ENSMUST00000097419.8 ENSMUST00000097419.9 Fgfr1op NM_001197046 Q32P17 Q66JX5 Q8BH91 uc008ajc.1 uc008ajc.2 uc008ajc.3 uc008ajc.4 Required for anchoring microtubules to the centrosomes. Required for ciliation. Homodimer. Part of a ternary complex that contains CEP350, CEP43 and MAPRE1. Interacts directly with CEP350 and MAPRE1. Interacts with CEP19. Interacts (via N-terminus) with CEP350 (via C-terminus). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body Note=Associated with gamma- tubulin. Localizes on both mother and daughter centrioles. Localizes to an axial position on the mother centriole. Localizes to the distal end of the centriole partly to the subdistal appendage region. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q66JX5-1; Sequence=Displayed; Name=2; IsoId=Q66JX5-2; Sequence=VSP_018122; Belongs to the CEP43 family. nucleus cytoplasm centrosome centriole microtubule organizing center cytoskeleton negative regulation of protein kinase activity positive regulation of cell proliferation protein kinase binding cell projection organization protein tyrosine kinase inhibitor activity positive regulation of cell growth positive regulation of cell migration microtubule anchoring protein homodimerization activity cell projection perinuclear region of cytoplasm negative regulation of protein tyrosine kinase activity uc008ajc.1 uc008ajc.2 uc008ajc.3 uc008ajc.4 
ENSMUST00000097423.3 Rsph3a ENSMUST00000097423.3 radial spoke 3A homolog (Chlamydomonas) (from RefSeq NM_025789.5) ENSMUST00000097423.1 ENSMUST00000097423.2 NM_025789 Q3UFY4 Q9D8J2 RSH3A_MOUSE Rshl2 Rshl2a uc008ait.1 uc008ait.2 uc008ait.3 uc008ait.4 May function as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (By similarity). Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity). May be a component of axonemal radial spokes (By similarity). Interacts with IQUB (By similarity). Interacts with phosphorylated MAPK1. Interacts with MEK1. Interacts with PKA regulatory subunits PRKAR1A and PRKAR1B (By similarity). Interacts with RSPH1. Interacts with RSPH4A. Interacts with RSPH6A. Interacts with RSPH9 (By similarity). Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme Belongs to the flagellar radial spoke RSP3 family. Sequence=BAB25385.1; Type=Frameshift; Evidence=; molecular_function cytoplasm cytoskeleton cilium biological_process cell projection uc008ait.1 uc008ait.2 uc008ait.3 uc008ait.4 
ENSMUST00000097430.10 Sytl3 ENSMUST00000097430.10 synaptotagmin-like 3, transcript variant 1 (from RefSeq NM_031395.3) ENSMUST00000097430.1 ENSMUST00000097430.2 ENSMUST00000097430.3 ENSMUST00000097430.4 ENSMUST00000097430.5 ENSMUST00000097430.6 ENSMUST00000097430.7 ENSMUST00000097430.8 ENSMUST00000097430.9 NM_031395 Q3KQQ0 Q8C506 Q99N47 Q99N48 Q99N49 Q99N54 Q99N79 SYTL3_MOUSE Slp3 uc008ahp.1 uc008ahp.2 uc008ahp.3 May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions. Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus. Endomembrane system; Peripheral membrane protein. Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Slp3-a; IsoId=Q99N48-1; Sequence=Displayed; Name=2; Synonyms=Slp3-a + 3S-I; IsoId=Q99N48-2; Sequence=VSP_007895; Name=3; Synonyms=Slp3-b, Slp3-a delta 3S-II; IsoId=Q99N48-3; Sequence=VSP_007896; Name=4; Synonyms=Slp3-b + 3S-III; IsoId=Q99N48-4; Sequence=VSP_007897; Name=5; IsoId=Q99N48-5; Sequence=VSP_007898, VSP_007899; Highly expressed in spleen and lung. Detected at lower levels in heart and testis. protein binding phospholipid binding calcium-dependent phospholipid binding intracellular protein transport exocytosis zinc ion binding endomembrane system membrane Rab GTPase binding extrinsic component of plasma membrane neurexin family protein binding exocytic vesicle uc008ahp.1 uc008ahp.2 uc008ahp.3 
ENSMUST00000097432.10 Serac1 ENSMUST00000097432.10 serine active site containing 1, transcript variant 3 (from RefSeq NM_001111017.1) D17Ertd141e ENSMUST00000097432.1 ENSMUST00000097432.2 ENSMUST00000097432.3 ENSMUST00000097432.4 ENSMUST00000097432.5 ENSMUST00000097432.6 ENSMUST00000097432.7 ENSMUST00000097432.8 ENSMUST00000097432.9 NM_001111017 Q3TS62 Q3U213 Q9D2G7 SRAC1_MOUSE uc008afz.1 uc008afz.2 uc008afz.3 uc008afz.4 Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway (By similarity). Membrane ; Single-pass membrane protein Endoplasmic reticulum Mitochondrion Note=Localizes at the endoplasmic reticulum and at the endoplasmic reticulum-mitochondria interface. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U213-1; Sequence=Displayed; Name=2; IsoId=Q3U213-2; Sequence=VSP_022864; Name=3; IsoId=Q3U213-3; Sequence=VSP_022865, VSP_022866; Testis. Belongs to the SERAC1 family. mitochondrion endoplasmic reticulum lipid metabolic process phospholipid biosynthetic process membrane integral component of membrane extracellular matrix organization extracellular matrix intracellular cholesterol transport phosphatidylglycerol acyl-chain remodeling ER-mitochondrion membrane contact site uc008afz.1 uc008afz.2 uc008afz.3 uc008afz.4 
ENSMUST00000097442.9 Ptpn14 ENSMUST00000097442.9 protein tyrosine phosphatase, non-receptor type 14 (from RefSeq NM_008976.2) ENSMUST00000097442.1 ENSMUST00000097442.2 ENSMUST00000097442.3 ENSMUST00000097442.4 ENSMUST00000097442.5 ENSMUST00000097442.6 ENSMUST00000097442.7 ENSMUST00000097442.8 G5E8M1 NM_008976 PTN14_MOUSE Q62130 uc007eau.1 uc007eau.2 uc007eau.3 Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Interacts with FLT4; the interaction is enhanced by stimulation with VEGFC. Interacts (via PPxY motifs) with YAP1 (via WW domains); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity. Cytoplasm Cytoplasm, cytoskeleton Nucleus Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane. Thymus; in cells of both hematopoietic and non- hematopoietic origins. Ubiquitinated by the ECS (Elongin BC-CUL2/5-SOCS-box protein)/LRR1 E3 ligase complex and subsequently targeted to proteasomal degradation. PTPN14 deficient mice have swelling of the limbs or periorbital edema. These mice also show hyperplasia of lymphatic capillaries of the ears. There is no evidence of choanal atresia or any overtly dysmorphic features. Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. lymphangiogenesis transcription cofactor activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus nucleoplasm cytoplasm cytoskeleton protein dephosphorylation negative regulation of cell proliferation dephosphorylation hydrolase activity phosphatase activity receptor tyrosine kinase binding peptidyl-tyrosine dephosphorylation regulation of protein export from nucleus regulation of nucleic acid-templated transcription uc007eau.1 uc007eau.2 uc007eau.3 
ENSMUST00000097450.10 Cdc42bpa ENSMUST00000097450.10 CDC42 binding protein kinase alpha, transcript variant 4 (from RefSeq NM_001359541.1) B2RY49 ENSMUST00000097450.1 ENSMUST00000097450.2 ENSMUST00000097450.3 ENSMUST00000097450.4 ENSMUST00000097450.5 ENSMUST00000097450.6 ENSMUST00000097450.7 ENSMUST00000097450.8 ENSMUST00000097450.9 Kiaa0451 MRCKA_MOUSE NM_001359541 Q3UU96 Q4V9U7 Q6ZQA9 Q8R495 uc007dvu.1 uc007dvu.2 uc007dvu.3 uc007dvu.4 Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LRP35A, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A and LIMK2. May play a role in TFRC-mediated iron uptake (By similarity). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (PubMed:25107909). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation. Inhibited by chelerythrine chloride (By similarity). Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42. Forms a tripartite complex with MYO18A and LRP35A with the latter acting as an adapter connecting CDC42BPA and MYO18A. LRP35A binding results in activation of CDC42BPA by abolition of its negative autoregulation. Interacts with LURAP1 (By similarity). Interacts (via AGC-kinase C- terminal domain) with FAM89B/LRAP25 (via LRR repeat). Forms a tripartite complex with FAM89B/LRAP25 and LIMK1 (PubMed:25107909). Cytoplasm Cell projection, lamellipodium Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner (PubMed:25107909). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UU96-1; Sequence=Displayed; Name=2; IsoId=Q3UU96-2; Sequence=VSP_023679, VSP_023680; Proteolytically cleaved by caspases upon apoptosis induction. The cleavage at Asp-478 by CASP3 increases its kinase activity (in vitro). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. nucleotide binding microtubule cytoskeleton organization magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm cytoskeleton cell-cell junction protein phosphorylation cytoskeleton organization nuclear migration kinase activity phosphorylation cell migration transferase activity peptidyl-threonine phosphorylation lamellipodium actin cytoskeleton organization actomyosin structure organization cell leading edge actin cytoskeleton reorganization intracellular signal transduction actomyosin identical protein binding cell projection metal ion binding regulation of small GTPase mediated signal transduction uc007dvu.1 uc007dvu.2 uc007dvu.3 uc007dvu.4 
ENSMUST00000097454.4 Gm10518 ENSMUST00000097454.4 Gm10518 (from geneSymbol) ENSMUST00000097454.1 ENSMUST00000097454.2 ENSMUST00000097454.3 uc287oiq.1 uc287oiq.2 uc287oiq.3 uc287oiq.1 uc287oiq.2 uc287oiq.3 
ENSMUST00000097466.3 Gm10521 ENSMUST00000097466.3 Gm10521 (from geneSymbol) ENSMUST00000097466.1 ENSMUST00000097466.2 uc287nvx.1 uc287nvx.2 uc287nvx.1 uc287nvx.2 
ENSMUST00000097474.9 Rcsd1 ENSMUST00000097474.9 RCSD domain containing 1, transcript variant 2 (from RefSeq NM_001038846.1) CPZIP_MOUSE Capzip ENSMUST00000097474.1 ENSMUST00000097474.2 ENSMUST00000097474.3 ENSMUST00000097474.4 ENSMUST00000097474.5 ENSMUST00000097474.6 ENSMUST00000097474.7 ENSMUST00000097474.8 NM_001038846 Q3TAD8 Q3TBC2 Q3TGA5 Q3UZA1 Q8R3A0 uc007djk.1 uc007djk.2 uc007djk.3 Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. Interacts with CAPZA2 and CAPZB. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UZA1-1; Sequence=Displayed; Name=2; IsoId=Q3UZA1-2; Sequence=VSP_031649; Dephosphorylation results in its dissociation from CAPZA2. skeletal muscle contraction cellular_component actin filament binding cellular hyperosmotic response uc007djk.1 uc007djk.2 uc007djk.3 
ENSMUST00000097490.5 ENSMUSG00000094836 ENSMUST00000097490.5 ENSMUSG00000094836 (from geneSymbol) ENSMUST00000097490.1 ENSMUST00000097490.2 ENSMUST00000097490.3 ENSMUST00000097490.4 uc291cfk.1 uc291cfk.2 uc291cfk.1 uc291cfk.2 
ENSMUST00000097494.9 9930111J21Rik1 ENSMUST00000097494.9 RIKEN cDNA 9930111J21 gene 1 (from RefSeq NM_001114679.1) 9930111J21Rik1 ENSMUST00000097494.1 ENSMUST00000097494.2 ENSMUST00000097494.3 ENSMUST00000097494.4 ENSMUST00000097494.5 ENSMUST00000097494.6 ENSMUST00000097494.7 ENSMUST00000097494.8 NM_001114679 Q5SVP0 Q5SVP0_MOUSE uc011xtz.1 uc011xtz.2 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. GTPase activity GTP binding endoplasmic reticulum membrane defense response membrane cellular response to interferon-beta uc011xtz.1 uc011xtz.2 
ENSMUST00000097495.5 Dok6 ENSMUST00000097495.5 docking protein 6 (from RefSeq NM_001039173.2) B2RSP9 DOK6_MOUSE ENSMUST00000097495.1 ENSMUST00000097495.2 ENSMUST00000097495.3 ENSMUST00000097495.4 NM_001039173 Q2MHE5 uc008fvr.1 uc008fvr.2 uc008fvr.3 uc008fvr.4 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance (By similarity). Interacts via its PTB domain with phosphorylated RET. Q2MHE5; Q6VNS1: Ntrk3; NbExp=3; IntAct=EBI-20585476, EBI-16744951; PTB domain mediates receptor interaction. On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase. Belongs to the DOK family. Type B subfamily. protein binding cellular_component biological_process uc008fvr.1 uc008fvr.2 uc008fvr.3 uc008fvr.4 
ENSMUST00000097514.8 Gm10530 ENSMUST00000097514.8 Gm10530 (from geneSymbol) AK158557 ENSMUST00000097514.1 ENSMUST00000097514.2 ENSMUST00000097514.3 ENSMUST00000097514.4 ENSMUST00000097514.5 ENSMUST00000097514.6 ENSMUST00000097514.7 uc287mza.1 uc287mza.2 uc287mza.1 uc287mza.2 
ENSMUST00000097522.11 Hdhd2 ENSMUST00000097522.11 haloacid dehalogenase-like hydrolase domain containing 2, transcript variant 1 (from RefSeq NM_029826.2) ENSMUST00000097522.1 ENSMUST00000097522.10 ENSMUST00000097522.2 ENSMUST00000097522.3 ENSMUST00000097522.4 ENSMUST00000097522.5 ENSMUST00000097522.6 ENSMUST00000097522.7 ENSMUST00000097522.8 ENSMUST00000097522.9 HDHD2_MOUSE NM_029826 Q3U8M0 Q3UGR5 Q6PEB2 Q9CXN1 Q9DCF2 uc008fqt.1 uc008fqt.2 uc008fqt.3 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UGR5-1; Sequence=Displayed; Name=2; IsoId=Q3UGR5-2; Sequence=VSP_025374, VSP_025375; Belongs to the HAD-like hydrolase superfamily. Sequence=BAB22395.1; Type=Frameshift; Evidence=; dephosphorylation phosphatase activity enzyme binding metal ion binding uc008fqt.1 uc008fqt.2 uc008fqt.3 
ENSMUST00000097527.10 Tor1aip1 ENSMUST00000097527.10 torsin A interacting protein 1, transcript variant 4 (from RefSeq NM_001405435.1) E9QLK1 ENSMUST00000097527.1 ENSMUST00000097527.2 ENSMUST00000097527.3 ENSMUST00000097527.4 ENSMUST00000097527.5 ENSMUST00000097527.6 ENSMUST00000097527.7 ENSMUST00000097527.8 ENSMUST00000097527.9 NM_001405435 Q1EQW1 Q3U7A4 Q921T2 TOIP1_MOUSE uc007dbw.1 uc007dbw.2 uc007dbw.3 uc007dbw.4 Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. Interacts with ATP1B4. Interacts with TOR1A (ATP-bound). Interacts with TOR1B, TOR2A and TOR3A. Interacts with VIM. Nucleus inner membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q921T2-1; Sequence=Displayed; Name=2; IsoId=Q921T2-2; Sequence=VSP_042953; Name=3; IsoId=Q921T2-3; Sequence=VSP_042952; Expressed in the spinal cord and liver (at protein level). At 16 dpc, widely expressed with high expression levels in hippocampus and low levels in heart. In the spinal cord, expressed as early as 12 dpc until p21, the expression levels decrease in the adulthood (at protein level). Mutant mice exhibit perinatal mortality, typically dying on the last prenatal or first postnatal day. All tissues tested exhibit nuclear membrane abnormalities with membranous vesicle-appearing structures observed in the perinuclear space of neurons. Belongs to the TOR1AIP family. Sequence=BAE31466.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ATPase activator activity protein binding lamin binding nucleus nuclear envelope nuclear inner membrane cytoskeletal protein binding membrane integral component of membrane nuclear membrane positive regulation of ATPase activity ATPase binding nuclear membrane organization protein localization to nuclear envelope uc007dbw.1 uc007dbw.2 uc007dbw.3 uc007dbw.4 
ENSMUST00000097542.4 Cep76 ENSMUST00000097542.4 centrosomal protein 76, transcript variant 2 (from RefSeq NM_001357523.1) CEP76_MOUSE ENSMUST00000097542.1 ENSMUST00000097542.2 ENSMUST00000097542.3 NM_001357523 Q0VEJ0 uc008fmr.1 uc008fmr.2 uc008fmr.3 Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication (By similarity). Interacts with CCP110 and CEP97. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Does not localize along the ciliary axoneme. Belongs to the CEP76 family. molecular_function cytoplasm centrosome centriole microtubule organizing center cytoskeleton macromolecular complex regulation of centriole replication uc008fmr.1 uc008fmr.2 uc008fmr.3 
ENSMUST00000097557.5 Spink13 ENSMUST00000097557.5 serine peptidase inhibitor, Kazal type 13 (from RefSeq NM_001168423.2) ENSMUST00000097557.1 ENSMUST00000097557.2 ENSMUST00000097557.3 ENSMUST00000097557.4 ISK13_MOUSE NM_001168423 Q3UTS8 Spink5l3 uc012bdy.1 uc012bdy.2 uc012bdy.3 May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity). Secreted Note=Secreted into the lumen of the initial segment of the epididymis and binds to sperm. In the initial segment of epididymis, localizes on the dorsal surface of the acrosomal region of sperm, gradually becomes more restricted to the acrosomal region in spermatozoa during epididymal transit (By similarity). serine-type endopeptidase inhibitor activity extracellular region negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity negative regulation of acrosome reaction uc012bdy.1 uc012bdy.2 uc012bdy.3 
ENSMUST00000097561.9 Csrp1 ENSMUST00000097561.9 cysteine and glycine-rich protein 1, transcript variant 1 (from RefSeq NM_001360782.2) Csrp1 ENSMUST00000097561.1 ENSMUST00000097561.2 ENSMUST00000097561.3 ENSMUST00000097561.4 ENSMUST00000097561.5 ENSMUST00000097561.6 ENSMUST00000097561.7 ENSMUST00000097561.8 NM_001360782 Q4FJX4 Q4FJX4_MOUSE uc287mag.1 uc287mag.2 Could play a role in neuronal development. Interacts with ASCC1; ASCC2 and TRIP4. Nucleus nucleus metal ion binding uc287mag.1 uc287mag.2 
ENSMUST00000097563.9 Cd74 ENSMUST00000097563.9 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), transcript variant 1 (from RefSeq NM_001042605.1) Cd74 ENSMUST00000097563.1 ENSMUST00000097563.2 ENSMUST00000097563.3 ENSMUST00000097563.4 ENSMUST00000097563.5 ENSMUST00000097563.6 ENSMUST00000097563.7 ENSMUST00000097563.8 Ii NM_001042605 Q3U4Q8 Q3U4Q8_MOUSE uc008faz.1 uc008faz.2 uc008faz.3 Lacks conserved residue(s) required for the propagation of feature annotation. activation of MAPK activity prostaglandin biosynthetic process beta-amyloid binding positive regulation of protein phosphorylation positive regulation of cytokine-mediated signaling pathway negative regulation of peptide secretion cytokine receptor activity nucleus cytoplasm vacuole plasma membrane protein folding intracellular protein transport immune response signal transduction cell proliferation cell surface positive regulation of gene expression membrane integral component of membrane cytokine-mediated signaling pathway antigen processing and presentation cytokine binding MHC class II protein complex binding negative regulation of cell migration positive regulation of B cell proliferation positive regulation of prostaglandin biosynthetic process macromolecular complex positive regulation of kinase activity macrophage migration inhibitory factor receptor complex macrophage migration inhibitory factor binding MHC class II protein binding CD4 receptor binding MHC class II protein binding, via antigen binding groove negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade negative regulation of DNA damage response, signal transduction by p53 class mediator protein binding involved in protein folding positive regulation of chemokine biosynthetic process positive regulation of interleukin-6 biosynthetic process positive regulation of interleukin-8 biosynthetic process positive regulation of monocyte differentiation positive regulation of transcription, DNA-templated positive regulation of viral entry into host cell positive regulation of fibroblast proliferation positive regulation of peptidyl-tyrosine phosphorylation protein heterotetramerization protein trimerization positive regulation of ERK1 and ERK2 cascade negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of macrophage migration inhibitory factor signaling pathway uc008faz.1 uc008faz.2 uc008faz.3 
ENSMUST00000097587.5 Spink11 ENSMUST00000097587.5 Spink11 (from geneSymbol) A0A0R4J158 A0A0R4J158_MOUSE DQ437331 ENSMUST00000097587.1 ENSMUST00000097587.2 ENSMUST00000097587.3 ENSMUST00000097587.4 Spink11 uc008euu.1 uc008euu.2 uc008euu.3 membrane integral component of membrane uc008euu.1 uc008euu.2 uc008euu.3 
ENSMUST00000097588.9 Srgap2 ENSMUST00000097588.9 SLIT-ROBO Rho GTPase activating protein 2 (from RefSeq NM_001081011.2) B2RY13 ENSMUST00000097588.1 ENSMUST00000097588.2 ENSMUST00000097588.3 ENSMUST00000097588.4 ENSMUST00000097588.5 ENSMUST00000097588.6 ENSMUST00000097588.7 ENSMUST00000097588.8 Fbp27 Fnbp2 NM_001081011 Q3V1V8 Q61054 Q91Z67 SRGP2_MOUSE Srgap2 uc007cng.1 uc007cng.2 uc007cng.3 uc007cng.4 Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:19737524, PubMed:22559944, PubMed:27373832). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:19737524, PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (PubMed:27373832). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:19737524, PubMed:22559944, PubMed:26439400). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (PubMed:26439400). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:22559944). Homodimer (PubMed:19737524). Forms a heterooligomer with SRGAP1 and SRGAP3 through its F-BAR domain (By similarity). Interacts (via SH3 domain) with GPHN (PubMed:22126966, PubMed:27373832). Interacts (via SH3 domain) with FMNL1 (activated by RAC1); regulates the actin filament severing activity of FMNL1 and actin dynamics (PubMed:21148482). Interacts (via SH3 domain) with FMNL3 (PubMed:21148482). Interacts with RAC1; specifically stimulates RAC1 GTPase activity (PubMed:19737524). Interacts (via F-BAR domain) with HOMER1 (PubMed:27373832). Interacts with ROBO1 and ROBO2 (PubMed:21148482). Interacts with FASLG (By similarity). Interacts with PRMT5 (By similarity). Cell membrane Cell projection, dendritic spine Postsynaptic density Postsynaptic cell membrane Cell projection, lamellipodium Cytoplasmic vesicle, phagosome Nucleus Cytoplasm, cytosol Note=Recruited to actin-rich phagosomes during phagocytosis (PubMed:21148482). Translocates from nucleus to cytoplasm during development (By similarity). Expressed throughout cortical development culminating at P1. Expression is reduced but still present in the adult cortex. Expressed in the cortical wall both in neuronal progenitors in the ventricular zone and post-mitotic neurons in the cortical plate (at protein level). The F-BAR domain mediates oligomerization, binds membranes, and induces plasma membrane protrusions. Methylation at Arg-927 is required for the stimulation of cell migration, dimerization and localization at the plasma membrane protrusions. Mice are viable and show no abnormality of cortical lamination. However, a delay in dendritic spine maturation coupled to an increase in spine neck and spine density is observed. Name=Protein Spotlight; Note=Branching out - Issue 143 of October 2012; URL="https://web.expasy.org/spotlight/back_issues/143"; lamellipodium assembly involved in ameboidal cell migration GTPase activator activity nucleus cytoplasm mitochondrial inner membrane cytosol plasma membrane signal transduction nervous system development postsynaptic density membrane extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration lamellipodium cell junction negative regulation of cell migration cytoplasmic vesicle substrate adhesion-dependent cell spreading identical protein binding protein homodimerization activity cell projection dendritic spine positive regulation of GTPase activity dendritic spine head synapse postsynaptic membrane phagocytic vesicle filopodium assembly Rac GTPase binding neuron projection morphogenesis actin filament severing dendritic spine development negative regulation of neuron migration uc007cng.1 uc007cng.2 uc007cng.3 uc007cng.4 
ENSMUST00000097590.5 Lars1 ENSMUST00000097590.5 leucyl-tRNA synthetase 1 (from RefSeq NM_134137.3) ENSMUST00000097590.1 ENSMUST00000097590.2 ENSMUST00000097590.3 ENSMUST00000097590.4 Lars NM_134137 Q8BKW9 Q8BMJ2 SYLC_MOUSE uc008etp.1 uc008etp.2 uc008etp.3 uc008etp.4 Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA. To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre- transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing). Reaction=ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl- tRNA(Leu); Xref=Rhea:RHEA:11688, Rhea:RHEA-COMP:9613, Rhea:RHEA- COMP:9622, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57427, ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:456215; EC=6.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11689; Evidence=; Reaction=H2O + L-methionyl-tRNA(Leu) = H(+) + L-methionine + tRNA(Leu); Xref=Rhea:RHEA:77535, Rhea:RHEA-COMP:9613, Rhea:RHEA-COMP:18931, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77536; Evidence=; 5-fluoro-1,3-dihydro-1-hydroxy-1,2-benzoxaborole inhibits LARS1 by forming a covalent adduct with the 3' adenosine of tRNA(Leu) at the editing site, thus locking the enzyme in an inactive conformation. Cytoplasm The structure of cytoplasmic leucine-tRNA ligase includes four main functional domains: the Rossmann-fold aminoacylation domain, the editing domain known as connective peptide 1 (CP1), the anticodon binding domain for tRNA recognition, and the vertebrate C-terminal (VC) domain for tRNA binding. Belongs to the class-I aminoacyl-tRNA synthetase family. nucleotide binding aminoacyl-tRNA editing activity aminoacyl-tRNA ligase activity glutamine-tRNA ligase activity leucine-tRNA ligase activity GTPase activator activity ATP binding cytoplasm lysosome endoplasmic reticulum cytosol translation tRNA aminoacylation for protein translation glutaminyl-tRNA aminoacylation leucyl-tRNA aminoacylation protein targeting to lysosome regulation of cell size negative regulation of autophagy endomembrane system nuclear body ligase activity aminoacyl-tRNA synthetase multienzyme complex cellular response to amino acid starvation positive regulation of GTPase activity cellular response to amino acid stimulus cellular response to leucine positive regulation of TORC1 signaling cellular response to leucine starvation uc008etp.1 uc008etp.2 uc008etp.3 uc008etp.4 
ENSMUST00000097591.5 Grxcr2 ENSMUST00000097591.5 glutaredoxin, cysteine rich 2 (from RefSeq NM_001033426.3) ENSMUST00000097591.1 ENSMUST00000097591.2 ENSMUST00000097591.3 ENSMUST00000097591.4 GRCR2_MOUSE Gm851 NM_001033426 Q3TYQ5 Q3TYR5 uc008etj.1 uc008etj.2 uc008etj.3 uc008etj.4 uc008etj.5 Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection. Cell projection, stereocilium Expressed in sensory hair cells in the cochlea and vestibular organ. Mice appear normal at postnatal week 2, but develop progressive hearing loss associated with early defects in orientation and organization of cochlear stereocilia bundles. They have normal vestibular function. Belongs to the GRXCR1 family. Although it shares high sequence similarity with GRXCR1, it does not contain a canonical glutaredoxin domain. molecular_function microvillus sensory perception of sound stereocilium cell projection uc008etj.1 uc008etj.2 uc008etj.3 uc008etj.4 uc008etj.5 
ENSMUST00000097612.4 Gm10545 ENSMUST00000097612.4 predicted gene 10545 (from RefSeq NR_188858.1) ENSMUST00000097612.1 ENSMUST00000097612.2 ENSMUST00000097612.3 NR_188858 uc289otk.1 uc289otk.2 uc289otk.1 uc289otk.2 
ENSMUST00000097617.3 Smim33 ENSMUST00000097617.3 small integral membrane protein 33 (from RefSeq NM_001033168.2) ENSMUST00000097617.1 ENSMUST00000097617.2 NM_001033168 Q3TS39 SIM33_MOUSE SMIM33 uc008ems.1 uc008ems.2 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc008ems.1 uc008ems.2 
ENSMUST00000097618.10 Ecscr ENSMUST00000097618.10 endothelial cell surface expressed chemotaxis and apoptosis regulator, transcript variant 3 (from RefSeq NM_001033141.2) C3RSF3 ECSCR_MOUSE ENSMUST00000097618.1 ENSMUST00000097618.2 ENSMUST00000097618.3 ENSMUST00000097618.4 ENSMUST00000097618.5 ENSMUST00000097618.6 ENSMUST00000097618.7 ENSMUST00000097618.8 ENSMUST00000097618.9 Ecsm2 NM_001033141 Q3TZW0 uc008emr.1 uc008emr.2 uc008emr.3 Regulates endothelial chemotaxis and tube formation (By similarity). Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. Interacts with FLNA. Interacts with the 20S proteasome subunit PSMA7. Cell membrane ; Single-pass type I membrane protein Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TZW0-1; Sequence=Displayed; Name=2; IsoId=Q3TZW0-2; Sequence=VSP_036454; Name=3; IsoId=Q3TZW0-3; Sequence=VSP_053880; Expressed in all tissues examined, highest expression was observed in lung and spleen endothelial cells. May be heavily O-glycosylated. Belongs to the ECSCR family. angiogenesis nucleoplasm cytoplasm cytosol plasma membrane apoptotic process chemotaxis multicellular organism development membrane integral component of membrane negative regulation of angiogenesis cell differentiation intracellular membrane-bounded organelle positive regulation of proteasomal protein catabolic process positive regulation of endothelial cell apoptotic process uc008emr.1 uc008emr.2 uc008emr.3 
ENSMUST00000097632.5 Gal3st2c ENSMUST00000097632.5 galactose-3-O-sulfotransferase 2C (from RefSeq NM_001039219.3) EG619597 ENSMUST00000097632.1 ENSMUST00000097632.2 ENSMUST00000097632.3 ENSMUST00000097632.4 Gal3st2c Gm6086 NM_001039219 Q3ULK5 Q3ULK5_MOUSE uc007cet.1 uc007cet.2 uc007cet.3 Belongs to the galactose-3-O-sulfotransferase family. galactosylceramide sulfotransferase activity cellular_component Golgi apparatus sulfotransferase activity glycolipid biosynthetic process membrane integral component of membrane uc007cet.1 uc007cet.2 uc007cet.3 
ENSMUST00000097633.10 D2hgdh ENSMUST00000097633.10 D-2-hydroxyglutarate dehydrogenase, transcript variant 2 (from RefSeq NM_178882.5) D2HDH_MOUSE E9QLL1 ENSMUST00000097633.1 ENSMUST00000097633.2 ENSMUST00000097633.3 ENSMUST00000097633.4 ENSMUST00000097633.5 ENSMUST00000097633.6 ENSMUST00000097633.7 ENSMUST00000097633.8 ENSMUST00000097633.9 NM_178882 Q149H0 Q3TDF5 Q8BU06 Q8CIM3 uc007cep.1 uc007cep.2 uc007cep.3 uc007cep.4 uc007cep.5 Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (By similarity). Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (By similarity). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (By similarity). Reaction=(R)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2; Xref=Rhea:RHEA:38295, ChEBI:CHEBI:13193, ChEBI:CHEBI:15801, ChEBI:CHEBI:16810, ChEBI:CHEBI:17499; EC=1.1.99.39; Evidence=; Reaction=(R)-malate + A = AH2 + oxaloacetate; Xref=Rhea:RHEA:67460, ChEBI:CHEBI:13193, ChEBI:CHEBI:15588, ChEBI:CHEBI:16452, ChEBI:CHEBI:17499; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67461; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Activated by zinc and cobalt ions. Mitochondrion Belongs to the FAD-binding oxidoreductase/transferase type 4 family. catalytic activity mitochondrion response to manganese ion response to zinc ion oxidoreductase activity response to cobalt ion cellular protein metabolic process flavin adenine dinucleotide binding (R)-2-hydroxyglutarate dehydrogenase activity oxidation-reduction process FAD binding response to magnesium ion response to calcium ion uc007cep.1 uc007cep.2 uc007cep.3 uc007cep.4 uc007cep.5 
ENSMUST00000097642.4 Cops9 ENSMUST00000097642.4 COP9 signalosome subunit 9, transcript variant 1 (from RefSeq NM_001163425.1) CSN9_MOUSE Cops9 ENSMUST00000097642.1 ENSMUST00000097642.2 ENSMUST00000097642.3 Myeov2 NM_001163425 Q3U898 uc007cbq.1 uc007cbq.2 uc007cbq.3 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation. Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9. In the complex, it interacts directly with COPS3, COPS5 and COPS6. Nucleus Cytoplasm Nucleus, nucleoplasm Note=Excluded from the nucleolus. Recruited to the nucleoplasm and chromatin following DNA damage induction. The Phe/Asp-rich domain at the C-terminus is necessary for its incorporation into the CSN complex. Belongs to the CSN9 family. nuclear chromatin molecular_function nucleus nucleoplasm cytoplasm COP9 signalosome positive regulation of cell proliferation cellular response to UV cytoplasmic sequestering of protein negative regulation of protein neddylation uc007cbq.1 uc007cbq.2 uc007cbq.3 
ENSMUST00000097644.9 Hdac4 ENSMUST00000097644.9 histone deacetylase 4 (from RefSeq NM_207225.2) ENSMUST00000097644.1 ENSMUST00000097644.2 ENSMUST00000097644.3 ENSMUST00000097644.4 ENSMUST00000097644.5 ENSMUST00000097644.6 ENSMUST00000097644.7 ENSMUST00000097644.8 HDAC4_MOUSE NM_207225 Q3TRZ9 Q3U2J3 Q3V3Y4 Q6NZM9 uc007cbg.1 uc007cbg.2 uc007cbg.3 uc007cbg.4 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Deacetylates HSPA1A and HSPA1A at 'Lys-77' leading to their preferential binding to co-chaperone STUB1. Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA- COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58197; Evidence=; Homodimer. Homodimerization via its N-terminal domain (By similarity). Interacts with HDAC7 (PubMed:10984530). Interacts with MEF2A, MEF2C, MEF2D, MORC2 and NR2C1. Interacts with a 14-3-3 chaperone proteins in a phosphorylation dependent manner. Interacts with 14-3-3 protein YWHAB (By similarity). Interacts with BTBD14B. Interacts with KDM5B. Interacts (via PxLPxI/L motif) with ANKRA2 (via ankyrin repeats). Interacts with CUL7 (as part of the 3M complex); negatively regulated by ANKRA2. Interacts with EP300 in the presence of TFAP2C (By similarity). Interacts with AHRR (PubMed:17949687). Interacts with MYOCD (PubMed:15601857). Interacts with HSPA1A and HSPA1B leading to their deacetylation at 'Lys-77' (By similarity). Interacts with ZBTB7B; the interaction allows the recruitment of HDAC4 on CD8 loci for deacetylation and possible inhibition of CD8 genes expression (PubMed:22730529). Interacts with DHX36 (PubMed:21590736). Interacts with SIK3; this interaction leads to HDAC4 retention in the cytoplasm (PubMed:22318228). Interacts with ZNF638 (By similarity). Q6NZM9; P23242: Gja1; NbExp=2; IntAct=EBI-646397, EBI-298630; Q6NZM9; Q08775: Runx2; NbExp=3; IntAct=EBI-646397, EBI-903354; Nucleus Cytoplasm Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-245, Ser-465 and Ser-629 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation (By similarity). Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (PubMed:22318228). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NZM9-1; Sequence=Displayed; Name=2; IsoId=Q6NZM9-2; Sequence=VSP_023952, VSP_023953; The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm. The PxLPxI/L motif mediates interaction with ankyrin repeats of ANKRA2. Phosphorylated by CaMK4 at Ser-245, Ser-465 and Ser-629. Phosphorylation at other residues by CaMK2D is required for the interaction with 14-3-3. Phosphorylation at Ser-349, within the PxLPxI/L motif, impairs the binding of ANKRA2 but generates a high- affinity docking site for 14-3-3 (By similarity). Sumoylation on Lys-556 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4. Belongs to the histone deacetylase family. HD type 2 subfamily. histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor binding skeletal system development osteoblast development DNA binding chromatin binding transcription corepressor activity histone deacetylase activity protein binding nucleus nucleoplasm cytoplasm cytosol chromatin organization chromatin remodeling protein deacetylation transcription factor binding zinc ion binding positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of lamellipodium assembly negative regulation of myotube differentiation regulation of cardiac muscle contraction by calcium ion signaling response to denervation involved in regulation of muscle adaptation positive regulation of smooth muscle cell migration histone deacetylation hydrolase activity protein sumoylation transcriptional repressor complex SUMO transferase activity protein kinase binding sarcomere Z disc potassium ion binding neuromuscular junction A band NAD-dependent histone deacetylase activity (H3-K14 specific) macromolecular complex positive regulation of protein sumoylation protein deacetylase activity activating transcription factor binding peptidyl-lysine deacetylation regulation of gene expression, epigenetic response to drug actomyosin identical protein binding histone deacetylase binding regulation of protein binding negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of neuron apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of osteoblast differentiation negative regulation of glycolytic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of smooth muscle cell proliferation regulation of skeletal muscle fiber development positive regulation of sequence-specific DNA binding transcription factor activity regulation of striated muscle cell differentiation repressing transcription factor binding response to interleukin-1 histone H3 deacetylation histone H4 deacetylation cellular response to mechanical stimulus cellular response to tumor necrosis factor cellular response to parathyroid hormone stimulus positive regulation of male mating behavior negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of reactive oxygen species biosynthetic process promoter-specific chromatin binding uc007cbg.1 uc007cbg.2 uc007cbg.3 uc007cbg.4 
ENSMUST00000097646.5 2700062C07Rik ENSMUST00000097646.5 RIKEN cDNA 2700062C07 gene (from RefSeq NM_026529.4) CR021_MOUSE ENSMUST00000097646.1 ENSMUST00000097646.2 ENSMUST00000097646.3 ENSMUST00000097646.4 NM_026529 Q5XFZ0 Q9CXC1 Q9CZ41 uc008egt.1 uc008egt.2 uc008egt.3 Belongs to the UPF0711 family. Sequence=BAB28609.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc008egt.1 uc008egt.2 uc008egt.3 
ENSMUST00000097648.6 Ramp1 ENSMUST00000097648.6 receptor (calcitonin) activity modifying protein 1, transcript variant 1 (from RefSeq NM_016894.3) ENSMUST00000097648.1 ENSMUST00000097648.2 ENSMUST00000097648.3 ENSMUST00000097648.4 ENSMUST00000097648.5 NM_016894 Q9WTJ5 RAMP1_MOUSE uc007bzx.1 uc007bzx.2 uc007bzx.3 uc007bzx.4 Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. Heterodimer of CALCRL and RAMP1. Membrane ; Single-pass type I membrane protein Expressed predominantly in the thymus, skeletal muscle, embryonic and adult brain, embryonic and adult lung, and colon. Belongs to the RAMP family. angiogenesis calcitonin gene-related peptide receptor activity extracellular space cell plasma membrane calcium ion transport intracellular protein transport G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway regulation of G-protein coupled receptor protein signaling pathway cell surface coreceptor activity protein transport membrane integral component of membrane receptor internalization cellular response to hormone stimulus receptor complex positive regulation of protein glycosylation protein localization to plasma membrane amylin receptor activity amylin receptor signaling pathway CGRP receptor complex calcitonin gene-related peptide binding calcitonin gene-related peptide receptor signaling pathway uc007bzx.1 uc007bzx.2 uc007bzx.3 uc007bzx.4 
ENSMUST00000097653.11 Col6a3 ENSMUST00000097653.11 collagen, type VI, alpha 3, transcript variant 2 (from RefSeq NM_001243009.1) Col6a3 ENSMUST00000097653.1 ENSMUST00000097653.10 ENSMUST00000097653.2 ENSMUST00000097653.3 ENSMUST00000097653.4 ENSMUST00000097653.5 ENSMUST00000097653.6 ENSMUST00000097653.7 ENSMUST00000097653.8 ENSMUST00000097653.9 J3QQ16 J3QQ16_MOUSE NM_001243009 uc029qrp.1 uc029qrp.2 uc029qrp.3 growth plate cartilage chondrocyte morphogenesis serine-type endopeptidase inhibitor activity collagen trimer extracellular space negative regulation of endopeptidase activity extracellular matrix structural constituent conferring tensile strength extracellular matrix sarcolemma uc029qrp.1 uc029qrp.2 uc029qrp.3 
ENSMUST00000097659.5 Ugt1a5 ENSMUST00000097659.5 UDP glucuronosyltransferase 1 family, polypeptide A5 (from RefSeq NM_201643.2) B2RT14 B2RT14_MOUSE ENSMUST00000097659.1 ENSMUST00000097659.2 ENSMUST00000097659.3 ENSMUST00000097659.4 NM_201643 Ugt1a5 uc007byh.1 uc007byh.2 uc007byh.3 Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; Endoplasmic reticulum membrane ; Single-pass membrane protein Membrane ; Single- pass membrane protein Belongs to the UDP-glycosyltransferase family. endoplasmic reticulum glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups enzyme binding protein homodimerization activity protein heterodimerization activity cellular glucuronidation uc007byh.1 uc007byh.2 uc007byh.3 
ENSMUST00000097672.4 Fbxo36 ENSMUST00000097672.4 F-box protein 36 (from RefSeq NM_025386.3) ENSMUST00000097672.1 ENSMUST00000097672.2 ENSMUST00000097672.3 FBX36_MOUSE NM_025386 Q9CQ24 uc007btc.1 uc007btc.2 uc007btc.3 uc007btc.4 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Directly interacts with SKP1 and CUL1. molecular_function cellular_component uc007btc.1 uc007btc.2 uc007btc.3 uc007btc.4 
ENSMUST00000097694.11 Retreg2 ENSMUST00000097694.11 reticulophagy regulator family member 2, transcript variant 1 (from RefSeq NM_170755.3) ENSMUST00000097694.1 ENSMUST00000097694.10 ENSMUST00000097694.2 ENSMUST00000097694.3 ENSMUST00000097694.4 ENSMUST00000097694.5 ENSMUST00000097694.6 ENSMUST00000097694.7 ENSMUST00000097694.8 ENSMUST00000097694.9 Fam134a NM_170755 Q3TA48 Q3TMF7 Q6NS82 Q8BSD3 Q8CHY1 Q8R0Q3 RETR2_MOUSE uc007bnt.1 uc007bnt.2 uc007bnt.3 Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (PubMed:34338405). Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAPL1 and GABARAPL2 (PubMed:34338405). Also interacts with ATG8 family modifier protein GABARAP (By similarity). Interacts with CANX (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6NS82-1; Sequence=Displayed; Name=2; IsoId=Q6NS82-2; Sequence=VSP_014550, VSP_014551; Name=3; IsoId=Q6NS82-3; Sequence=VSP_014551; Widely expressed with highest levels in brain, lung, heart, liver and kidney (at protein level) (PubMed:34338405). Mainly expressed in the central nervous system and in parenchymatous organs including liver, lung and kidney. The LIR motif interacts with ATG8 family proteins. Belongs to the RETREG family. Sequence=BAC28789.1; Type=Frameshift; Evidence=; molecular_function biological_process membrane integral component of membrane uc007bnt.1 uc007bnt.2 uc007bnt.3 
ENSMUST00000097713.2 Plekhm3 ENSMUST00000097713.2 pleckstrin homology domain containing, family M, member 3 (from RefSeq NM_001039493.1) Dapr ENSMUST00000097713.1 NM_001039493 PKHM3_MOUSE Plekhm3 Q3T9Y1 Q8BM47 uc007bha.1 uc007bha.2 Involved in skeletal muscle differentiation (PubMed:19028694). May act as a scaffold protein for AKT1 during muscle differentiation (PubMed:19028694). Interacts with AKT1. Cytoplasm Golgi apparatus Cell membrane Note=Before differentiation of muscle cells, localized to the cytosol. During muscle differentiation shuttles to the plasma membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BM47-1; Sequence=Displayed; Name=2; IsoId=Q8BM47-2; Sequence=VSP_032514, VSP_032515; Widely expressed (PubMed:19028694). Expressed in C2C12 cells (at protein level) (PubMed:19028694). protein binding cytoplasm Golgi apparatus plasma membrane membrane myoblast differentiation metal ion binding uc007bha.1 uc007bha.2 
ENSMUST00000097715.4 Mrpl43 ENSMUST00000097715.4 mitochondrial ribosomal protein L43 (from RefSeq NM_053164.4) ENSMUST00000097715.1 ENSMUST00000097715.2 ENSMUST00000097715.3 Mrpl43 NM_053164 Q5RL20 Q5RL20_MOUSE uc008hqg.1 uc008hqg.2 uc008hqg.3 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: BC065812.1, AK076204.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mL43 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome mitochondrial translation uc008hqg.1 uc008hqg.2 uc008hqg.3 
ENSMUST00000097718.10 Ino80d ENSMUST00000097718.10 INO80 complex subunit D, transcript variant 10 (from RefSeq NM_001406708.1) E9Q9Q0 E9QLE8 ENSMUST00000097718.1 ENSMUST00000097718.2 ENSMUST00000097718.3 ENSMUST00000097718.4 ENSMUST00000097718.5 ENSMUST00000097718.6 ENSMUST00000097718.7 ENSMUST00000097718.8 ENSMUST00000097718.9 IN80D_MOUSE Ino80d NM_001406708 Q66JY2 Q8BQK5 uc287ira.1 uc287ira.2 uc287ira.3 Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Nucleus Event=Alternative splicing; Named isoforms=2; Name=3; IsoId=Q66JY2-3; Sequence=Displayed; Name=4; IsoId=Q66JY2-4; Sequence=VSP_060240; Belongs to the INO80D family. Sequence=AAH80705.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH80705.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; molecular_function nucleus DNA repair DNA recombination cellular response to DNA damage stimulus biological_process uc287ira.1 uc287ira.2 uc287ira.3 
ENSMUST00000097737.5 Pusl1 ENSMUST00000097737.5 pseudouridylate synthase-like 1 (from RefSeq NM_001033490.1) A2ADA5 ENSMUST00000097737.1 ENSMUST00000097737.2 ENSMUST00000097737.3 ENSMUST00000097737.4 NM_001033490 PUSL1_MOUSE Q3TVB3 Q3UAA3 uc012drb.1 uc012drb.2 uc012drb.3 uc012drb.4 Reaction=a uridine in tRNA = a pseudouridine in tRNA; Xref=Rhea:RHEA:54572, Rhea:RHEA-COMP:13339, Rhea:RHEA-COMP:13934, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2ADA5-1; Sequence=Displayed; Name=2; IsoId=A2ADA5-2; Sequence=VSP_036050, VSP_036051, VSP_036053; Name=3; IsoId=A2ADA5-3; Sequence=VSP_036049, VSP_036052, VSP_036054; Belongs to the tRNA pseudouridine synthase TruA family. pseudouridine synthesis RNA binding tRNA processing RNA modification pseudouridine synthase activity isomerase activity tRNA pseudouridine synthesis intracellular membrane-bounded organelle uc012drb.1 uc012drb.2 uc012drb.3 uc012drb.4 
ENSMUST00000097739.5 Pgap1 ENSMUST00000097739.5 post-GPI attachment to proteins 1 (from RefSeq NM_001163314.2) E9QKG7 ENSMUST00000097739.1 ENSMUST00000097739.2 ENSMUST00000097739.3 ENSMUST00000097739.4 NM_001163314 PGAP1_MOUSE Q3UUQ7 Q8BQ77 uc011wky.1 uc011wky.2 uc011wky.3 uc011wky.4 Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UUQ7-1; Sequence=Displayed; Name=2; IsoId=Q3UUQ7-2; Sequence=VSP_023045, VSP_023046; Belongs to the GPI inositol-deacylase family. nuclease activity endoplasmic reticulum endoplasmic reticulum membrane GPI anchor metabolic process GPI anchor biosynthetic process ER to Golgi vesicle-mediated transport sensory perception of sound embryonic pattern specification anterior/posterior axis specification protein transport myo-inositol transport membrane integral component of membrane hydrolase activity hydrolase activity, acting on ester bonds forebrain regionalization phosphoric ester hydrolase activity phosphatidylinositol deacylase activity head development nucleic acid phosphodiester bond hydrolysis uc011wky.1 uc011wky.2 uc011wky.3 uc011wky.4 
ENSMUST00000097740.3 Mxra8os ENSMUST00000097740.3 Mxra8os (from geneSymbol) AK007076 ENSMUST00000097740.1 ENSMUST00000097740.2 uc290snv.1 uc290snv.2 uc290snv.1 uc290snv.2 
ENSMUST00000097742.3 Tmem88b ENSMUST00000097742.3 transmembrane protein 88B (from RefSeq NM_001033394.3) A2AD92 ENSMUST00000097742.1 ENSMUST00000097742.2 NM_001033394 Q3TYP4 TM88B_MOUSE uc008wes.1 uc008wes.2 uc008wes.3 Membrane ; Multi-pass membrane protein Belongs to the TMEM88 family. plasma membrane biological_process membrane integral component of membrane PDZ domain binding uc008wes.1 uc008wes.2 uc008wes.3 
ENSMUST00000097750.3 Gm10564 ENSMUST00000097750.3 Gm10564 (from geneSymbol) AK144422 ENSMUST00000097750.1 ENSMUST00000097750.2 uc290sjt.1 uc290sjt.2 uc290sjt.1 uc290sjt.2 
ENSMUST00000097772.10 Il1rl1 ENSMUST00000097772.10 interleukin 1 receptor-like 1, transcript variant 1 (from RefSeq NM_001025602.4) ENSMUST00000097772.1 ENSMUST00000097772.2 ENSMUST00000097772.3 ENSMUST00000097772.4 ENSMUST00000097772.5 ENSMUST00000097772.6 ENSMUST00000097772.7 ENSMUST00000097772.8 ENSMUST00000097772.9 ILRL1_MOUSE Ly84 NM_001025602 P14719 Q05208 St2 Ste2 uc007aub.1 uc007aub.2 uc007aub.3 uc007aub.4 uc007aub.5 uc007aub.6 Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP (PubMed:18450470, PubMed:17675517, PubMed:29045903, PubMed:22660580). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 (By similarity). Possibly involved in helper T-cell function (By similarity). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (PubMed:34644537). [Isoform B]: Inhibits IL-33 signaling. Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302; Evidence=; Interacts with MYD88, IRAK1, IRAK4, and TRAF6 (By similarity). Bound to its ligand IL33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88. Interacts with TMED1. P14719; Q61730: Il1rap; NbExp=3; IntAct=EBI-525078, EBI-525035; P14719; Q6PCT2: FBXL19; Xeno; NbExp=3; IntAct=EBI-525078, EBI-6664563; Cell membrane; Single-pass type I membrane protein. [Isoform B]: Secreted. Event=Alternative splicing; Named isoforms=2; Name=A; Synonyms=Membrane-bound, ST2L; IsoId=P14719-1; Sequence=Displayed; Name=B; Synonyms=Soluble, ST2; IsoId=P14719-2; Sequence=VSP_002668, VSP_002669; Predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines. Isoform A is expressed in brain astrocytes and microglia. Isoform B is expressed in brain endothelial cells. Expressed first in the fetal liver and then in lung and hematopoietic tissues. The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. Phosphorylated by GSK3B at Ser-442; leading to proteasomal degradation. Ubiquitinated at Lys-326 in a FBXL19-mediated manner; leading to proteasomal degradation (PubMed:22660580). Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response (By similarity). In response to cardiotoxin-induced muscle injury, mutant mice show impaired inflammation resolution characterized by deficient muscle fiber regeneration and impaired clearance of necrotic cells. Belongs to the interleukin-1 receptor family. interleukin-33 binding interleukin-33 receptor activity negative regulation of T-helper 1 type immune response interleukin-1 receptor activity protein binding extracellular region extracellular space plasma membrane signal transduction negative regulation of cell proliferation external side of plasma membrane cell surface membrane integral component of membrane cytokine-mediated signaling pathway extracellular matrix negative regulation of interferon-gamma production positive regulation of interleukin-5 production interleukin-33-mediated signaling pathway positive regulation of macrophage activation negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of inflammatory response positive regulation of chemokine secretion uc007aub.1 uc007aub.2 uc007aub.3 uc007aub.4 uc007aub.5 uc007aub.6 
ENSMUST00000097773.4 Klhl21 ENSMUST00000097773.4 kelch-like 21 (from RefSeq NM_001033352.3) B1AS70 ENSMUST00000097773.1 ENSMUST00000097773.2 ENSMUST00000097773.3 KLH21_MOUSE NM_001033352 Q3TZ30 Q3U410 uc008vyy.1 uc008vyy.2 uc008vyy.3 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity). Protein modification; protein ubiquitination. Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1. Cytoplasm, cytoskeleton, spindle Note=Localizes to the spindle midzone and targets CUL3 to this region. Sequence=BAE34380.1; Type=Erroneous initiation; Evidence=; Golgi membrane ubiquitin-protein transferase activity cytoplasm spindle polar microtubule cytoskeleton protein monoubiquitination cell cycle protein ubiquitination ER to Golgi transport vesicle Cul3-RING ubiquitin ligase complex regulation of cytokinesis chromosome passenger complex localization to spindle midzone COPII vesicle coating cell division uc008vyy.1 uc008vyy.2 uc008vyy.3 
ENSMUST00000097799.10 Pramel61 ENSMUST00000097799.10 predicted gene 13102 (from RefSeq NM_001085419.1) A2ASJ3 E0CXV0 ENSMUST00000097799.1 ENSMUST00000097799.2 ENSMUST00000097799.3 ENSMUST00000097799.4 ENSMUST00000097799.5 ENSMUST00000097799.6 ENSMUST00000097799.7 ENSMUST00000097799.8 ENSMUST00000097799.9 F6SEH0 Gm13102 NM_001085419 OTTMUSG00000010432 Pramel4 Q3ULC4 Q3ULC4_MOUSE uc290rmz.1 uc290rmz.2 uc290rmz.3 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290rmz.1 uc290rmz.2 uc290rmz.3 
ENSMUST00000097801.4 Spata31e2 ENSMUST00000097801.4 spermatogenesis associated 31 subfamily E member 2 (from RefSeq NM_001033764.3) 4931408C20Rik E9PWP9 E9PWP9_MOUSE ENSMUST00000097801.1 ENSMUST00000097801.2 ENSMUST00000097801.3 NM_001033764 uc007amz.1 uc007amz.2 uc007amz.3 uc007amz.4 Membrane ; Single- pass membrane protein Belongs to the SPATA31 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007amz.1 uc007amz.2 uc007amz.3 uc007amz.4 
ENSMUST00000097809.11 Rims1 ENSMUST00000097809.11 Rims1 (from geneSymbol) AK220335 ENSMUST00000097809.1 ENSMUST00000097809.10 ENSMUST00000097809.2 ENSMUST00000097809.3 ENSMUST00000097809.4 ENSMUST00000097809.5 ENSMUST00000097809.6 ENSMUST00000097809.7 ENSMUST00000097809.8 ENSMUST00000097809.9 F6VBV0 F6VBV0_MOUSE Rims1 uc287gvd.1 uc287gvd.2 intracellular protein transport exocytosis membrane Rab GTPase binding metal ion binding presynaptic active zone uc287gvd.1 uc287gvd.2 
ENSMUST00000097813.3 Cplane2 ENSMUST00000097813.3 ciliogenesis and planar polarity effector 2 (from RefSeq NM_001081174.2) 6330545A04Rik B2RWG6 B2RWG6_MOUSE Cplane2 ENSMUST00000097813.1 ENSMUST00000097813.2 NM_001081174 Rsg1 uc012doa.1 uc012doa.2 uc012doa.3 Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells. Cytoplasm, cytoskeleton, cilium basal body Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding nucleoplasm uc012doa.1 uc012doa.2 uc012doa.3 
ENSMUST00000097817.4 Defb41 ENSMUST00000097817.4 defensin beta 41, transcript variant 2 (from RefSeq NM_001040027.3) DFB41_MOUSE Defb16 Defb17 Defb41 ENSMUST00000097817.1 ENSMUST00000097817.2 ENSMUST00000097817.3 Gm15386 NM_001040027 Q30KP6 Q4FZ55 Q8C1G4 uc007ako.1 uc007ako.2 uc007ako.3 Has bactericidal activity. Isoform 2 may play a role in the antimicrobial protection of sperm and urogenital tract epithelia. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q30KP6-1; Sequence=Displayed; Name=2; IsoId=Q30KP6-2; Sequence=VSP_057922; Isoform 2 is epididymis-specific and expressed mainly in the proximal caput. By androgens. Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium innate immune response uc007ako.1 uc007ako.2 uc007ako.3 
ENSMUST00000097818.2 Defb18 ENSMUST00000097818.2 defensin beta 18 (from RefSeq NM_001039123.2) DFB18_MOUSE ENSMUST00000097818.1 NM_001039123 Q30KP5 uc007akm.1 uc007akm.2 Has antibacterial activity. Secreted Belongs to the beta-defensin family. molecular_function cellular_component extracellular region defense response biological_process defense response to bacterium innate immune response uc007akm.1 uc007akm.2 
ENSMUST00000097822.10 Ubr4 ENSMUST00000097822.10 ubiquitin protein ligase E3 component n-recognin 4 (from RefSeq NM_001160319.1) A2AN07 A2AN08 A2AN09 A2AN10 A2AN11 ENSMUST00000097822.1 ENSMUST00000097822.2 ENSMUST00000097822.3 ENSMUST00000097822.4 ENSMUST00000097822.5 ENSMUST00000097822.6 ENSMUST00000097822.7 ENSMUST00000097822.8 ENSMUST00000097822.9 Kiaa0462 NM_001160319 Q52KI4 Q6PB49 Q6PFC7 Q80Y11 Q8BGB9 Q8C3E8 Q8C4W5 Q8C8X7 Q8CGE0 Q8CHF3 UBR4_MOUSE Zubr1 uc008vmm.1 uc008vmm.2 uc008vmm.3 uc008vmm.4 uc008vmm.5 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin- mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with RB1 and calmodulin. A2AN08; P06933: E7; Xeno; NbExp=2; IntAct=EBI-4285947, EBI-7730971; Membrane ; Multi-pass membrane protein Cytoplasm Cytoplasm, cytoskeleton Nucleus Note=Concentrates at the leading edge of membrane structures involved in actin motility. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A2AN08-1; Sequence=Displayed; Name=2; IsoId=A2AN08-2; Sequence=VSP_025210; Name=3; IsoId=A2AN08-3; Sequence=VSP_025213, VSP_025215; Name=4; IsoId=A2AN08-4; Sequence=VSP_025211, VSP_025212; Name=5; IsoId=A2AN08-5; Sequence=VSP_025214; Widely expressed in adult and embryonic stages with highest levels in testis and brain. Belongs to the UBR4 family. Sequence=BAC39609.1; Type=Erroneous initiation; Evidence=; ubiquitin-protein transferase activity protein binding calmodulin binding nucleus nucleoplasm cytoplasm centrosome cytosol cytoskeleton ubiquitin-dependent protein catabolic process zinc ion binding membrane integral component of membrane protein ubiquitination transferase activity metal ion binding uc008vmm.1 uc008vmm.2 uc008vmm.3 uc008vmm.4 uc008vmm.5 
ENSMUST00000097830.4 Otud3 ENSMUST00000097830.4 OTU domain containing 3, transcript variant 2 (from RefSeq NM_028453.2) B1AZ99 ENSMUST00000097830.1 ENSMUST00000097830.2 ENSMUST00000097830.3 NM_028453 OTUD3_MOUSE uc008vln.1 uc008vln.2 uc008vln.3 uc008vln.4 Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin (PubMed:35675826). Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (PubMed:35675826). Important regulator of energy metabolism (PubMed:35675826). Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation (PubMed:35675826). In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation (PubMed:35675826). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598- mediated 40S ubiquitination (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; B1AZ99; O08586: Pten; NbExp=2; IntAct=EBI-16170692, EBI-1186266; Cytoplasm Nucleus Note=Glucose or fatty acid promote nuclear translocation upon acetylation. The UBA-like domain has no influence on ubiquitin hydrolysis. Specificity is given by the S1' ubiquitin-binding site within the OTU domain composed of the Cys-, His- and Variable-loops. Glucose and fatty acids stimulate CREBBP-dependent acetylation, promoting its nuclear translocation. Knockout mice develope worse obesity, dyslipidemia and insulin resistance than wild-type mice when challenged with a high-fat diet. thiol-dependent ubiquitin-specific protease activity protein binding cytoplasm proteolysis peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity protein K11-linked deubiquitination thiol-dependent ubiquitinyl hydrolase activity protein K6-linked deubiquitination protein stabilization negative regulation of protein kinase B signaling protein K48-linked deubiquitination protein K27-linked deubiquitination uc008vln.1 uc008vln.2 uc008vln.3 uc008vln.4 
ENSMUST00000097843.9 Cnr2 ENSMUST00000097843.9 cannabinoid receptor 2, transcript variant 1 (from RefSeq NM_009924.4) CNR2_MOUSE ENSMUST00000097843.1 ENSMUST00000097843.2 ENSMUST00000097843.3 ENSMUST00000097843.4 ENSMUST00000097843.5 ENSMUST00000097843.6 ENSMUST00000097843.7 ENSMUST00000097843.8 NM_009924 P47936 Q544H5 uc009vdb.1 uc009vdb.2 uc009vdb.3 uc009vdb.4 Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Cell membrane ; Multi-pass membrane protein Cell projection, dendrite Perikaryon Note=Localizes to apical dendrite of pyramidal neurons. Expressed by cells of hematopoietic origin. Expressed in skin in suprabasal layers and hair follicles, in brain by neurons and glial cells and by osteoblasts, osteocytes, osteoclasts (at protein level). Mutant mice are responsive to the psychotropic effects of cannabinoid but not to the cannabinoid-induced immunomodulation. They also show accelerated age-related trabecular bone loss and cortical expansion. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity cannabinoid receptor activity plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane sensory perception of pain dendrite leukocyte chemotaxis extrinsic component of cytoplasmic side of plasma membrane negative regulation of synaptic transmission, GABAergic response to lipopolysaccharide negative regulation of mast cell activation cannabinoid signaling pathway cell projection neuron projection neuronal cell body perikaryon negative regulation of action potential negative regulation of inflammatory response negative regulation of nitric-oxide synthase activity uc009vdb.1 uc009vdb.2 uc009vdb.3 uc009vdb.4 
ENSMUST00000097849.3 Zpld2 ENSMUST00000097849.3 zona pellucida like domain containing 2 (from RefSeq NM_001080712.1) EG665186 ENSMUST00000097849.1 ENSMUST00000097849.2 Gm7534 NM_001080712 Q3UU21 Q3UU21_MOUSE Zpld2 uc008veg.1 uc008veg.2 molecular_function cellular_component biological_process uc008veg.1 uc008veg.2 
ENSMUST00000097864.9 Pum1 ENSMUST00000097864.9 pumilio RNA-binding family member 1, transcript variant 6 (from RefSeq NM_001356564.1) ENSMUST00000097864.1 ENSMUST00000097864.2 ENSMUST00000097864.3 ENSMUST00000097864.4 ENSMUST00000097864.5 ENSMUST00000097864.6 ENSMUST00000097864.7 ENSMUST00000097864.8 Kiaa0099 NM_001356564 PUM1_MOUSE Pum1 Q80U78 Q80X96 Q80YU8 Q8BPV7 Q9EPU6 uc008uzn.1 uc008uzn.2 uc008uzn.3 uc008uzn.4 uc008uzn.5 uc008uzn.6 Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (By similarity). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (By similarity). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (By similarity). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'- UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53 (PubMed:22342750). Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (PubMed:24412312). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (By similarity). Recruits the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (By similarity). Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (By similarity). Cytoplasm Cytoplasm, P-body Cytoplasmic granule Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80U78-1; Sequence=Displayed; Name=2; IsoId=Q80U78-2; Sequence=VSP_009317, VSP_009318; Name=3; IsoId=Q80U78-3; Sequence=VSP_009317; Name=4; IsoId=Q80U78-4; Sequence=VSP_009315, VSP_009316; Widely expressed. Expressed in brain, heart, kidney, liver, lung, skin, intestine, spleen, testis and thymus. Weakly or not expressed in muscles and stomach. Expressed at various stages of myeloid and lymphoid cell development (PubMed:12667987). Highly expressed in testis (PubMed:22342750). Expressed in all major brain regions (at protein level) (PubMed:25768905). During the development of the testis, expressed 2 days postpartum (dpp) and then starts to increase at 14 dpp when pachytene spermatocytes first appear. The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. RNA-binding occurs on the concave side of the surface. PUM1 is composed of 8 pumilio repeats of 36 residues; each repeat binds a single nucleotide in its RNA target. Residues at positions 12 and 16 of the pumilio repeat bind each RNA base via hydrogen bonding or van der Waals contacts with the Watson-Crick edge, while the amino acid at position 13 makes a stacking interaction. The recognition of RNA by pumilio repeats is base specific: cysteine and glutamine at position 12 and 16, respectively, bind adenine; asparagine and glutamine bind uracil; and serine and glutamate bind guanine. Phosphorylation at Ser-715 promotes RNA-binding activity. Following growth factor stimulation phosphorylated at Ser-715, promoting binding to the 3'-UTR of CDKN1B/p27 mRNA. Mice are viable and grow to adulthood without apparent defects except that they are smaller than wild-type mice at 8 weeks of age (PubMed:22342750, PubMed:25768905). Males mice however show significantly reduced sperm counts and fertility: testicular hypoplasia is observed (PubMed:22342750). Heterozygous knockout mice manifest neurological dysfunction, hyperactivity, and progressive cerebellar signs including gross and fine motor incoordination (PubMed:25768905, PubMed:29474920). They show spontaneous seizures, abnormal EEG activity with generalized epileptiform spikes by the age of 16 weeks, and have smaller than normal cerebella (PubMed:29474920). Sequence=BAC65487.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; P-body RNA binding mRNA 3'-UTR binding nucleus nucleoplasm cytoplasm cytosol regulation of translation spermatogenesis adult locomotory behavior cytoplasmic stress granule posttranscriptional regulation of gene expression posttranscriptional gene silencing nuclear speck cell differentiation production of miRNAs involved in gene silencing by miRNA miRNA binding regulation of mRNA stability stem cell differentiation regulation of cell cycle regulation of chromosome segregation mRNA destabilization positive regulation of RIG-I signaling pathway positive regulation of gene silencing by miRNA uc008uzn.1 uc008uzn.2 uc008uzn.3 uc008uzn.4 uc008uzn.5 uc008uzn.6 
ENSMUST00000097877.9 Zscan20 ENSMUST00000097877.9 zinc finger and SCAN domains 20 (from RefSeq NM_177758.4) B1AS93 B2KFW1 ENSMUST00000097877.1 ENSMUST00000097877.2 ENSMUST00000097877.3 ENSMUST00000097877.4 ENSMUST00000097877.5 ENSMUST00000097877.6 ENSMUST00000097877.7 ENSMUST00000097877.8 NM_177758 Q3UNF0 Q6DFW6 Q8BJ07 ZSC20_MOUSE Zfp31 uc008uvd.1 uc008uvd.2 uc008uvd.3 uc008uvd.4 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B2KFW1-1; Sequence=Displayed; Name=2; IsoId=B2KFW1-2; Sequence=VSP_036740; Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAH76602.1; Type=Erroneous initiation; Evidence=; Sequence=BAE25797.1; Type=Erroneous initiation; Evidence=; nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc008uvd.1 uc008uvd.2 uc008uvd.3 uc008uvd.4 
ENSMUST00000097886.4 5730409E04Rik ENSMUST00000097886.4 Belongs to the UPF0500 family. (from UniProt Q8BP99) A2A7K4 AK077438 CA216_MOUSE ENSMUST00000097886.1 ENSMUST00000097886.2 ENSMUST00000097886.3 Q8BP99 uc008utp.1 uc008utp.2 uc008utp.3 uc008utp.4 Belongs to the UPF0500 family. molecular_function cellular_component biological_process uc008utp.1 uc008utp.2 uc008utp.3 uc008utp.4 
ENSMUST00000097888.10 Ago1 ENSMUST00000097888.10 argonaute RISC catalytic subunit 1, transcript variant 1 (from RefSeq NM_153403.3) A1L365 AGO1_MOUSE ENSMUST00000097888.1 ENSMUST00000097888.2 ENSMUST00000097888.3 ENSMUST00000097888.4 ENSMUST00000097888.5 ENSMUST00000097888.6 ENSMUST00000097888.7 ENSMUST00000097888.8 ENSMUST00000097888.9 Eif2c1 NM_153403 Q8CJG1 uc008utj.1 uc008utj.2 uc008utj.3 uc008utj.4 uc008utj.5 This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]. Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. May also be required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). Interacts with DDB1, DDX5, DDX6, DHX30, DHX36, DDX47, DICER1, AGO2, ELAVL1, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, MOV10, PABPC1, PRMT5, RBM4, SART3, TNRC6B, UPF1 and YBX1. Associates with polysomes and messenger ribonucleoproteins (mNRPs) (By similarity). Interacts with LIMD1, WTIP and AJUBA (By similarity). Interacts with APOBEC3F, APOBEC3G and APOBEC3H (By similarity). Q8CJG1; Q8CH72: Trim32; NbExp=2; IntAct=EBI-2291996, EBI-773837; Cytoplasm, P-body Ubiquitinated on surface-exposed lysines by a SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 during target- directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). Ubiquitination by the SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 leads to its subsequent degradation, thereby exposing miRNAs for degradation. ZSWIM8 recognizes and binds AGO1 when it is engaged with a TDMD target. Belongs to the argonaute family. Ago subfamily. P-body nuclear-transcribed mRNA catabolic process RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core binding core promoter binding nucleic acid binding RNA binding double-stranded RNA binding single-stranded RNA binding protein binding nucleus cytoplasm cytosol polysome regulation of translation RNA secondary structure unwinding miRNA metabolic process positive regulation of gene expression RISC complex negative regulation of angiogenesis gene silencing by RNA pre-miRNA processing production of miRNAs involved in gene silencing by miRNA miRNA binding miRNA mediated inhibition of translation miRNA loading onto RISC involved in gene silencing by miRNA transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter RISC-loading complex positive regulation of NIK/NF-kappaB signaling ribonucleoprotein complex uc008utj.1 uc008utj.2 uc008utj.3 uc008utj.4 uc008utj.5 
ENSMUST00000097891.4 Sh3d21 ENSMUST00000097891.4 SH3 domain containing 21, transcript variant 1 (from RefSeq NM_001162533.1) ENSMUST00000097891.1 ENSMUST00000097891.2 ENSMUST00000097891.3 NM_001162533 Sh3d21 Z4YK11 Z4YK11_MOUSE uc008ust.1 uc008ust.2 uc008ust.3 uc008ust.4 uc008ust.1 uc008ust.2 uc008ust.3 uc008ust.4 
ENSMUST00000097896.4 4933427I04Rik ENSMUST00000097896.4 Riken cDNA 4933427I04 gene (from RefSeq NR_165172.1) ENSMUST00000097896.1 ENSMUST00000097896.2 ENSMUST00000097896.3 NR_165172 uc290pri.1 uc290pri.2 uc290pri.3 uc290pri.1 uc290pri.2 uc290pri.3 
ENSMUST00000097905.3 Gm12888 ENSMUST00000097905.3 predicted gene 12888 (from RefSeq NM_001033791.3) ENSMUST00000097905.1 ENSMUST00000097905.2 Gm12888 NM_001033791 OTTMUSG00000008911 Q3UW77 Q3UW77_MOUSE uc008uod.1 uc008uod.2 lysosome uc008uod.1 uc008uod.2 
ENSMUST00000097912.8 St3gal3 ENSMUST00000097912.8 ST3 beta-galactoside alpha-2,3-sialyltransferase 3, transcript variant 4 (from RefSeq NM_001285521.1) ENSMUST00000097912.1 ENSMUST00000097912.2 ENSMUST00000097912.3 ENSMUST00000097912.4 ENSMUST00000097912.5 ENSMUST00000097912.6 ENSMUST00000097912.7 NM_001285521 Q9CZ48 Q9CZ48_MOUSE Siat6 St3gal3 uc008ujm.1 uc008ujm.2 uc008ujm.3 uc008ujm.4 uc008ujm.5 Membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 29 family. Golgi apparatus protein glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups sialylation uc008ujm.1 uc008ujm.2 uc008ujm.3 uc008ujm.4 uc008ujm.5 
ENSMUST00000097918.3 Kncn ENSMUST00000097918.3 kinocilin, transcript variant 1 (from RefSeq NM_001320545.1) ENSMUST00000097918.1 ENSMUST00000097918.2 KNCN_MOUSE Kino NM_001320545 Q307W7 uc008ufo.1 uc008ufo.2 uc008ufo.3 uc008ufo.4 May play a role in stabilizing dense microtubular networks or in vesicular trafficking. Membrane ; Multi-pass membrane protein Preferentially expressed in the inner ear and testis. Localizes mainly in the kinocilium of sensory cells in the inner ear. Also present in the manchette of the spermatids, a transient structure enriched in interconnected microtubules (at protein level). First detected in the kinocilia of vestibular and auditory hair cells at embryonic days 14.5, and 18.5, respectively. In the mature vestibular hair cells, it is still present in the kinocilium. As the auditory hair cells begin to lose the kinocilium during postnatal development, it becomes distributed in an annular pattern at the apex of these cells, where it colocalizes with the tubulin belt. In mature auditory hair cells, it is also present at the level of the cuticular plate, at the base of each stereocilium. As the kinocilium regresses from developing auditory hair cells, it begins to be expressed by the pillar cells and Deiters cells, that both contain prominent transcellular and apical bundles of microtubules. Not detected in the supporting cells in the vestibular end organs (at protein level). molecular_function cytoplasm biological_process microtubule cytoskeleton membrane integral component of membrane apical plasma membrane cuticular plate ciliary basal body neuronal cell body apical part of cell kinocilium uc008ufo.1 uc008ufo.2 uc008ufo.3 uc008ufo.4 
ENSMUST00000097921.10 Cdkn2c ENSMUST00000097921.10 cyclin dependent kinase inhibitor 2C, transcript variant 1 (from RefSeq NM_001301368.1) CDN2C_MOUSE ENSMUST00000097921.1 ENSMUST00000097921.2 ENSMUST00000097921.3 ENSMUST00000097921.4 ENSMUST00000097921.5 ENSMUST00000097921.6 ENSMUST00000097921.7 ENSMUST00000097921.8 ENSMUST00000097921.9 NM_001301368 Q60772 uc008ucs.1 uc008ucs.2 uc008ucs.3 uc008ucs.4 The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (cdk) inhibitors, and contains five ankyrin repeats. This protein interacts with both Cdk4 and Cdk6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]. Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Heterodimer of p18 with CDK6. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. regulation of cyclin-dependent protein serine/threonine kinase activity G1/S transition of mitotic cell cycle cyclin-dependent protein serine/threonine kinase inhibitor activity nucleus cytoplasm cell cycle cell cycle arrest negative regulation of cell proliferation protein kinase binding negative regulation of cell growth negative regulation of phosphorylation negative regulation of cyclin-dependent protein serine/threonine kinase activity oligodendrocyte differentiation uc008ucs.1 uc008ucs.2 uc008ucs.3 uc008ucs.4 
ENSMUST00000097925.9 Tut4 ENSMUST00000097925.9 terminal uridylyl transferase 4, transcript variant 2 (from RefSeq NM_001379664.1) A2A8R7 A2A8R7_MOUSE ENSMUST00000097925.1 ENSMUST00000097925.2 ENSMUST00000097925.3 ENSMUST00000097925.4 ENSMUST00000097925.5 ENSMUST00000097925.6 ENSMUST00000097925.7 ENSMUST00000097925.8 NM_001379664 Tut4 Zcchc11 uc290onl.1 uc290onl.2 Reaction=RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide; Xref=Rhea:RHEA:14785, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17348, ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:140395, ChEBI:CHEBI:173116; EC=2.7.7.52; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; nucleic acid binding zinc ion binding nucleotidyltransferase activity uc290onl.1 uc290onl.2 
ENSMUST00000097928.3 Faddos ENSMUST00000097928.3 Faddos (from geneSymbol) AK145165 ENSMUST00000097928.1 ENSMUST00000097928.2 uc291xqd.1 uc291xqd.2 uc291xqd.1 uc291xqd.2 
ENSMUST00000097942.3 Krtap5-5 ENSMUST00000097942.3 keratin associated protein 5-5 (from RefSeq NM_001037822.1) ENSMUST00000097942.1 ENSMUST00000097942.2 KRA55_MOUSE Krtap5-5 NM_001037822 Q2TA51 uc009kmq.1 uc009kmq.2 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the KRTAP type 5 family. hematopoietic progenitor cell differentiation molecular_function cellular_component intermediate filament keratin filament uc009kmq.1 uc009kmq.2 
ENSMUST00000097943.2 Krtap5-21 ENSMUST00000097943.2 predicted gene 7579 (from RefSeq NM_001347555.1) A0A1B0GRJ4 A0A1B0GRJ4_MOUSE ENSMUST00000097943.1 Gm7579 NM_001347555 uc057lvz.1 uc057lvz.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc057lvz.1 uc057lvz.2 
ENSMUST00000097947.4 Gm10575 ENSMUST00000097947.4 predicted gene 10575, transcript variant 1 (from RefSeq NR_152219.1) ENSMUST00000097947.1 ENSMUST00000097947.2 ENSMUST00000097947.3 NR_152219 uc012fxf.1 uc012fxf.2 uc012fxf.1 uc012fxf.2 
ENSMUST00000097958.3 Sigirr ENSMUST00000097958.3 single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, transcript variant 1 (from RefSeq NM_023059.4) ENSMUST00000097958.1 ENSMUST00000097958.2 NM_023059 Q52L48 Q9JLZ8 SIGIR_MOUSE Tir8 uc009kjk.1 uc009kjk.2 Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor- proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity). Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3 (By similarity). Membrane ; Single-pass type III membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JLZ8-1; Sequence=Displayed; Name=2; IsoId=Q9JLZ8-2; Sequence=VSP_015718; Expressed at high levels in kidney, and at moderate levels in colon, small intestine, lung, spleen and liver. Not expressed in brain and muscle. Expressed at high levels in epithelial cells, at moderate levels in splenocytes, and at low or undetectable levels in fibroblasts or endothelial cells. Expressed in mucosal and dendritic cells. Down-regulated by LPS. Down-regulated during inflammation by inhibition of an SP1-mediated pathway. Belongs to the interleukin-1 receptor family. Sequence=AAF26200.1; Type=Frameshift; Evidence=; negative regulation of cytokine-mediated signaling pathway acute-phase response signal transduction membrane integral component of membrane negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of chemokine biosynthetic process uc009kjk.1 uc009kjk.2 
ENSMUST00000097961.9 Alg6 ENSMUST00000097961.9 ALG6 alpha-1,3-glucosyltransferase (from RefSeq NM_001081264.1) ALG6_MOUSE ENSMUST00000097961.1 ENSMUST00000097961.2 ENSMUST00000097961.3 ENSMUST00000097961.4 ENSMUST00000097961.5 ENSMUST00000097961.6 ENSMUST00000097961.7 ENSMUST00000097961.8 NM_001081264 Q3TAE8 Q3TZF4 uc008tuw.1 uc008tuw.2 uc008tuw.3 Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity). Reaction=a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)- alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man- (1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc- diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha- D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- (1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]- alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D- GlcNAc-diphosphodolichol + H(+); Xref=Rhea:RHEA:30635, Rhea:RHEA- COMP:9517, Rhea:RHEA-COMP:9528, Rhea:RHEA-COMP:12631, Rhea:RHEA- COMP:12632, ChEBI:CHEBI:15378, ChEBI:CHEBI:57525, ChEBI:CHEBI:57683, ChEBI:CHEBI:132520, ChEBI:CHEBI:132521; EC=2.4.1.267; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the ALG6/ALG8 glucosyltransferase family. endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation protein N-linked glycosylation dolichol-linked oligosaccharide biosynthetic process oligosaccharide-lipid intermediate biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity glucosyltransferase activity uc008tuw.1 uc008tuw.2 uc008tuw.3 
ENSMUST00000097964.3 I0C0044D17Rik ENSMUST00000097964.3 RIKEN cDNA I0C0044D17 gene (from RefSeq NR_151512.1) A6PWL3 A6PWL3_MOUSE ENSMUST00000097964.1 ENSMUST00000097964.2 I0C0044D17Rik NR_151512 uc290nyu.1 uc290nyu.2 molecular_function cellular_component biological_process uc290nyu.1 uc290nyu.2 
ENSMUST00000097972.5 Cyp2j12 ENSMUST00000097972.5 cytochrome P450, family 2, subfamily j, polypeptide 12, transcript variant 2 (from RefSeq NM_001355721.1) Cyp2j12 ENSMUST00000097972.1 ENSMUST00000097972.2 ENSMUST00000097972.3 ENSMUST00000097972.4 G3UXT0 G3UXT0_MOUSE NM_001355721 uc008ttg.1 uc008ttg.2 uc008ttg.3 uc008ttg.4 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc008ttg.1 uc008ttg.2 uc008ttg.3 uc008ttg.4 
ENSMUST00000097981.6 Cdkn2b ENSMUST00000097981.6 cyclin dependent kinase inhibitor 2B (from RefSeq NM_007670.4) Cdkn2b ENSMUST00000097981.1 ENSMUST00000097981.2 ENSMUST00000097981.3 ENSMUST00000097981.4 ENSMUST00000097981.5 NM_007670 Q549R4 Q549R4_MOUSE uc008tok.1 uc008tok.2 uc008tok.3 uc008tok.4 Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. regulation of cyclin-dependent protein serine/threonine kinase activity G2/M transition of mitotic cell cycle cyclin-dependent protein serine/threonine kinase inhibitor activity nucleus cytoplasm cell cycle arrest mitotic cell cycle checkpoint negative regulation of cell proliferation kinase activity phosphorylation protein kinase binding megakaryocyte differentiation positive regulation of transforming growth factor beta receptor signaling pathway cellular response to extracellular stimulus cellular response to nutrient negative regulation of phosphorylation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of epithelial cell proliferation cellular senescence uc008tok.1 uc008tok.2 uc008tok.3 uc008tok.4 
ENSMUST00000097983.5 Nps ENSMUST00000097983.5 neuropeptide S (from RefSeq NM_001163611.1) ENSMUST00000097983.1 ENSMUST00000097983.2 ENSMUST00000097983.3 ENSMUST00000097983.4 NM_001163611 NPS_MOUSE P0C0P8 uc012fvj.1 uc012fvj.2 uc012fvj.3 May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations. Secreted. molecular_function extracellular region neuropeptide signaling pathway visual learning positive regulation of circadian sleep/wake cycle, wakefulness positive regulation of synaptic transmission, GABAergic positive regulation of action potential positive regulation of synaptic transmission, glutamatergic uc012fvj.1 uc012fvj.2 uc012fvj.3 
ENSMUST00000097992.10 Focad ENSMUST00000097992.10 focadhesin, transcript variant 3 (from RefSeq NM_001419410.1) A2AKG8 ENSMUST00000097992.1 ENSMUST00000097992.2 ENSMUST00000097992.3 ENSMUST00000097992.4 ENSMUST00000097992.5 ENSMUST00000097992.6 ENSMUST00000097992.7 ENSMUST00000097992.8 ENSMUST00000097992.9 FOCAD_MOUSE Kiaa1797 NM_001419410 Q0P620 Q3TPY9 Q3UJY8 Q3UK73 Q6PGE3 uc008tmu.1 uc008tmu.2 uc008tmu.3 Required for the maintenance of SKIC2 and SKIC3 proteostatic levels in the liver. May be involved in the regulation of RNA degradation by the exosome complex (By similarity). Potential tumor suppressor in gliomas. Interacts with VCL. Cell junction, focal adhesion Cytoplasm, cytosol Note=In astrocytes, colocalizes with VCL to the end of actin stress fibers, which normally terminate at focal adhesions. In hepatocytes, it is found in the cytosol. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AKG8-1; Sequence=Displayed; Name=2; IsoId=A2AKG8-2; Sequence=VSP_030275, VSP_030276; Name=3; IsoId=A2AKG8-3; Sequence=VSP_030274; Expressed by glial and neuronal cells in brain. Sequence=BAE26929.1; Type=Erroneous initiation; Evidence=; Sequence=BAE27017.1; Type=Erroneous initiation; Evidence=; molecular_function focal adhesion biological_process membrane integral component of membrane cell junction uc008tmu.1 uc008tmu.2 uc008tmu.3 
ENSMUST00000097999.9 Fam53b ENSMUST00000097999.9 family with sequence similarity 53, member B, transcript variant 1 (from RefSeq NM_212473.1) ENSMUST00000097999.1 ENSMUST00000097999.2 ENSMUST00000097999.3 ENSMUST00000097999.4 ENSMUST00000097999.5 ENSMUST00000097999.6 ENSMUST00000097999.7 ENSMUST00000097999.8 FA53B_MOUSE Fam53b NM_212473 Q3UGW1 Q8BGR5 Q8BI13 uc009kci.1 uc009kci.2 uc009kci.3 Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. Interacts with CTNNB1. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGR5-1; Sequence=Displayed; Name=2; IsoId=Q8BGR5-2; Sequence=VSP_009934; Belongs to the FAM53 family. molecular_function nucleus protein import into nucleus Wnt signaling pathway regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway uc009kci.1 uc009kci.2 uc009kci.3 
ENSMUST00000098015.10 Gm49368 ENSMUST00000098015.10 Membrane ingle-pass type I membrane protein (from UniProt Q3U1U4) AK155717 ENSMUST00000098015.1 ENSMUST00000098015.2 ENSMUST00000098015.3 ENSMUST00000098015.4 ENSMUST00000098015.5 ENSMUST00000098015.6 ENSMUST00000098015.7 ENSMUST00000098015.8 ENSMUST00000098015.9 Gm49368 Q3U1U4 Q3U1U4_MOUSE uc009jya.1 uc009jya.2 uc009jya.3 Membrane ingle-pass type I membrane protein Belongs to the integrin alpha chain family. structural constituent of ribosome ribosome translation cell adhesion integrin-mediated signaling pathway integrin complex membrane integral component of membrane uc009jya.1 uc009jya.2 uc009jya.3 
ENSMUST00000098031.10 Rgs3 ENSMUST00000098031.10 Rgs3 (from geneSymbol) AK015722 ENSMUST00000098031.1 ENSMUST00000098031.2 ENSMUST00000098031.3 ENSMUST00000098031.4 ENSMUST00000098031.5 ENSMUST00000098031.6 ENSMUST00000098031.7 ENSMUST00000098031.8 ENSMUST00000098031.9 I7HPB2 I7HPB2_MOUSE Rgs3 uc290ndf.1 uc290ndf.2 uc290ndf.1 uc290ndf.2 
ENSMUST00000098040.4 Mup18 ENSMUST00000098040.4 major urinary protein 18 (from RefSeq NM_001199333.1) ENSMUST00000098040.1 ENSMUST00000098040.2 ENSMUST00000098040.3 MUP11_MOUSE Mup11 Mup9 NM_001199333 P04938 uc012dfn.1 uc012dfn.2 uc012dfn.3 uc012dfn.4 Major urinary proteins (Mups) bind pheromones, and thus stabilize them to allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance (Probable). Binds the pheromone analog 2- sec-butyl-4,5-dihydrothiazole (SBT) in vitro (PubMed:25279835). Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function insulin-activated receptor activity pheromone binding cellular_component extracellular region extracellular space nucleus cytosol energy reserve metabolic process behavior biological_process insulin receptor signaling pathway aerobic respiration positive regulation of gene expression negative regulation of lipid storage positive regulation of glucose metabolic process heat generation small molecule binding glucose homeostasis locomotor rhythm negative regulation of gluconeogenesis positive regulation of lipid metabolic process negative regulation of transcription, DNA-templated negative regulation of lipid biosynthetic process positive regulation of protein kinase B signaling negative regulation of insulin secretion involved in cellular response to glucose stimulus mitochondrion morphogenesis cellular response to testosterone stimulus cellular response to lipid uc012dfn.1 uc012dfn.2 uc012dfn.3 uc012dfn.4 
ENSMUST00000098046.10 Mup11 ENSMUST00000098046.10 major urinary protein 11 (from RefSeq NM_001164526.1) ENSMUST00000098046.1 ENSMUST00000098046.2 ENSMUST00000098046.3 ENSMUST00000098046.4 ENSMUST00000098046.5 ENSMUST00000098046.6 ENSMUST00000098046.7 ENSMUST00000098046.8 ENSMUST00000098046.9 MUP11_MOUSE Mup11 Mup9 NM_001164526 P04938 uc008taw.1 uc008taw.2 uc008taw.3 uc008taw.4 uc008taw.5 Major urinary proteins (Mups) bind pheromones, and thus stabilize them to allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance (Probable). Binds the pheromone analog 2- sec-butyl-4,5-dihydrothiazole (SBT) in vitro (PubMed:25279835). Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function insulin-activated receptor activity pheromone binding cellular_component extracellular region extracellular space nucleus cytosol energy reserve metabolic process behavior biological_process insulin receptor signaling pathway aerobic respiration positive regulation of gene expression negative regulation of lipid storage positive regulation of glucose metabolic process heat generation small molecule binding glucose homeostasis locomotor rhythm negative regulation of gluconeogenesis positive regulation of lipid metabolic process negative regulation of transcription, DNA-templated negative regulation of lipid biosynthetic process positive regulation of protein kinase B signaling negative regulation of insulin secretion involved in cellular response to glucose stimulus mitochondrion morphogenesis cellular response to testosterone stimulus cellular response to lipid uc008taw.1 uc008taw.2 uc008taw.3 uc008taw.4 uc008taw.5 
ENSMUST00000098047.3 Mup10 ENSMUST00000098047.3 major urinary protein 10 (from RefSeq NM_001122647.1) A2BIN1 A2BIN1_MOUSE ENSMUST00000098047.1 ENSMUST00000098047.2 Mup10 Mup8 NM_001122647 uc012dff.1 uc012dff.2 uc012dff.3 uc012dff.4 uc012dff.5 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc012dff.1 uc012dff.2 uc012dff.3 uc012dff.4 uc012dff.5 
ENSMUST00000098048.6 Tufm ENSMUST00000098048.6 Tu translation elongation factor, mitochondrial, transcript variant 1 (from RefSeq NM_172745.3) EFTU_MOUSE ENSMUST00000098048.1 ENSMUST00000098048.2 ENSMUST00000098048.3 ENSMUST00000098048.4 ENSMUST00000098048.5 NM_172745 Q497E7 Q6P919 Q8BFR5 uc009jrp.1 uc009jrp.2 uc009jrp.3 uc009jrp.4 Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. Interacts with NLRX1. Interacts with ATG16L1. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BFR5-1; Sequence=Displayed; Name=2; IsoId=Q8BFR5-2; Sequence=VSP_013942; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. nucleotide binding translation elongation factor activity GTPase activity GTP binding mitochondrion mitochondrial inner membrane translation translational elongation mitochondrial nucleoid myelin sheath synapse response to ethanol mitochondrial translational elongation uc009jrp.1 uc009jrp.2 uc009jrp.3 uc009jrp.4 
ENSMUST00000098056.6 Aqp8 ENSMUST00000098056.6 aquaporin 8, transcript variant 1 (from RefSeq NM_007474.2) AQP8_MOUSE Aqp8 ENSMUST00000098056.1 ENSMUST00000098056.2 ENSMUST00000098056.3 ENSMUST00000098056.4 ENSMUST00000098056.5 NM_007474 P56404 Q91XC2 uc057ajl.1 uc057ajl.2 uc057ajl.3 Channel that allows the facilitated permeation of water and uncharged molecules, such as hydrogen peroxide and the neutral form of ammonia (NH3), through cellular membranes such as plasma membrane, inner mitochondrial membrane and endoplasmic reticulum membrane of several tissues (PubMed:27256569, PubMed:9388476, PubMed:15647389, PubMed:15948717, PubMed:16624991, PubMed:21117174). The transport of ammonia neutral form induces a parallel transport of proton, at alkaline pH when the concentration of ammonia is high (By similarity). However, it is unclear whether the transport of proton takes place via the aquaporin or via an endogenous pathway (By similarity). Also, may transport ammonia analogs such as formamide and methylamine, a transport favourited at basic pH due to the increase of unprotonated (neutral) form, which is expected to favor diffusion (By similarity). In vitro, may be also permeable to urea but not to glycerol (PubMed:9388476). Does not transport urea or glycerol (By similarity). The water transport mechanism is mercury- and copper-sensitive and passive in response to osmotic driving forces (PubMed:9388476). At the canicular plasma membrane, mediates the osmotic transport of water toward the bile canaliculus and facilitates the cAMP-induced bile canalicular water secretion, a process involved in bile formation (By similarity). In addition, mediates the hydrogen peroxide release from hepatocyte mitochondria that modulates the SREBF2-mediated cholesterol synthesis and facilitates the mitochondrial ammonia uptake which is metabolized into urea, mainly under glucagon stimulation (By similarity). In B cells, transports the CYBB-generated hydrogen peroxide from the external leaflet of the plasma membrane to the cytosol to promote B cell activation and differentiation for signal amplification (PubMed:27256569). In the small intestine and colon system, mediates water transport through mitochondria and apical membrane of epithelial cells (By similarity). May play an important role in the adaptive response of proximal tubule cells to acidosis possibly facilitating mitochondrial ammonia transport (By similarity). Reaction=H2O(in) = H2O(out); Xref=Rhea:RHEA:29667, ChEBI:CHEBI:15377; Evidence= Reaction=urea(in) = urea(out); Xref=Rhea:RHEA:32799, ChEBI:CHEBI:16199; Evidence=; Reaction=NH4(+)(in) = NH4(+)(out); Xref=Rhea:RHEA:28747, ChEBI:CHEBI:28938; Evidence=; Reaction=H2O2(out) = H2O2(in); Xref=Rhea:RHEA:74375, ChEBI:CHEBI:16240; Evidence=; Reaction=formamide(out) = formamide(in); Xref=Rhea:RHEA:74387, ChEBI:CHEBI:16397; Evidence=; Reaction=methylamine(out) = methylamine(in); Xref=Rhea:RHEA:74391, ChEBI:CHEBI:59338; Evidence=; Reversibly gated by a two-step sulfenylation- persulfidation process in cells undergoing diverse stresses. Cell membrane ulti-pass membrane protein Mitochondrion inner membrane ulti-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Smooth endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Localized at the hepatocyte canalicular plasma membrane (PubMed:14512882). Localized at the apical membrane of the gall-bladder epithelial cells lining both the neck and corpus regions (PubMed:15859952). Localized on the apical membranes of pancreatic acinar cells and mucosal epithelium of the colon and jejunum. Trafficking from intracellular vesicles to the hepatocyte canalicular plasma membrane is induced by glucagon or the second messenger 3',5'- cyclic AMP and the translocation is protein kinase A and microtubule- dependent. Localized at the brush border membranes of epithelial cells from jejunum (By similarity). Localized at the luminal membranes of crypts in ascending colon (PubMed:15647389). Expressed in placenta (PubMed:9388476). Highly expressed in the epithelial layer of gall-bladders (PubMed:15859952). Expressed in heart, kidney, submandibular gland, liver, small intestine, colon, testes, and epididymis (PubMed:15647389, PubMed:9388476). In testes, expressed in spermatogenic cells (PubMed:15647389). Strongly expressed between fetal day 17 and birth as well as at weaning and thereafter. Down-regulated by fasting. Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Sulfenylation at Cys-53(C53-SOH) when hydrogen peroxide flows through the AQP8 channel, making it susceptible to hydrogen sulfide produced by CBS. Persulfidation at Cys-53 is required to gate AQP8 channel; under stress condition, hydrogen peroxide accumulates in the cell leading to CBS activation that produces hydrogen sulfide inducing persulfidation of oxidized Cys-53 (C53-SOH). N-glycosylated. Homozygous mice for AQP8 have normal appearance, survival, and growth (PubMed:15647389). Homozygous mice female for AQP8 exhibit increased fertility and numbers of oocytes in ovulation (PubMed:21117174). Homozygous male mice show an unaffected fertility (PubMed:21117174). Homozygous pregnant mice have a significantly higher number of embryos and fetal/neonatal weight is also significantly greater (PubMed:21602842). Exhibit a greater amount of amniotic fluid and placental weight is significantly larger (PubMed:21602842). Belongs to the MIP/aquaporin (TC 1.A.8) family. plasma membrane integral component of plasma membrane water transport water channel activity channel activity canalicular bile acid transport membrane integral component of membrane intracellular membrane-bounded organelle apical part of cell intracellular canaliculus transmembrane transport cellular response to cAMP uc057ajl.1 uc057ajl.2 uc057ajl.3 
ENSMUST00000098068.10 Palb2 ENSMUST00000098068.10 partner and localizer of BRCA2, transcript variant 1 (from RefSeq NM_001081238.2) ENSMUST00000098068.1 ENSMUST00000098068.2 ENSMUST00000098068.3 ENSMUST00000098068.4 ENSMUST00000098068.5 ENSMUST00000098068.6 ENSMUST00000098068.7 ENSMUST00000098068.8 ENSMUST00000098068.9 NM_001081238 PALB2_MOUSE Q3U0P1 Q6NZG9 Q7TMQ4 Q8CEA9 uc009joj.1 uc009joj.2 uc009joj.3 Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (By similarity). Homooligomer; dissociated upon DNA damage thus allowing association with BRCA1. Oligomerization is essential for its focal accumulation at DNA breaks. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts with BRCA1 and this interaction is essential for its function in HRR. Interacts with RAD51AP1 and MORF4L1/MRG15. Component of the homologous recombination repair (HR) complex composed of ERCC5/XPG, BRCA2, PALB2, DSS1 and RAD51 (By similarity). Within the complex, interacts with ERCC5/XPG and BRCA2 (By similarity). Interacts with BRCA2, RAD51C, RAD51 and XRCC3; the interactions are direct and it may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with POLH; the interaction is direct (By similarity). Nucleus Note=Colocalizes with BRCA2 in nuclear foci. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3U0P1-1; Sequence=Displayed; Name=2; IsoId=Q3U0P1-2; Sequence=VSP_020929; Name=3; IsoId=Q3U0P1-3; Sequence=VSP_020928; Name=4; IsoId=Q3U0P1-4; Sequence=VSP_020930, VSP_020931; Interaction with BRCA2 occurs through a hydrophobic pocket at the crossover between WD repeats 4 and 5. The coiled coil domain mediates self-association. The chromatin-association motif (ChAM) mediates association with chromatin, probably through nucleosome core particles, independently from binding to D loop, ssDNA or dsDNA structures. double-strand break repair via homologous recombination in utero embryonic development somitogenesis inner cell mass cell proliferation DNA binding nucleus nucleoplasm DNA repair DNA recombination cellular response to DNA damage stimulus mesoderm development animal organ morphogenesis multicellular organism growth post-anal tail morphogenesis negative regulation of apoptotic process embryonic organ development uc009joj.1 uc009joj.2 uc009joj.3 
ENSMUST00000098070.10 Zfp462 ENSMUST00000098070.10 zinc finger protein 462 (from RefSeq NM_172867.4) A2SW42 B1AWL2 ENSMUST00000098070.1 ENSMUST00000098070.2 ENSMUST00000098070.3 ENSMUST00000098070.4 ENSMUST00000098070.5 ENSMUST00000098070.6 ENSMUST00000098070.7 ENSMUST00000098070.8 ENSMUST00000098070.9 NM_172867 ZN462_MOUSE Zfp462 Znf462 uc008sxi.1 uc008sxi.2 uc008sxi.3 Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (PubMed:17353115). Regulates neuronal development and neural cell differentiation (PubMed:21570965, PubMed:27621227). Interacts with PBX1 isoform PBX1b; this interaction prevents PBX1-HOXA9 heterodimer from forming and binding to DNA. Nucleus Expressed in the cerebral cortex (at protein level) (PubMed:17207666, PubMed:27621227). Expressed in embryonic stem cells (at protein level) (PubMed:20219459). Expressed in heart, liver, kidney, muscle, and female and male genital tracts (at protein level) (PubMed:27621227, PubMed:17353115). Detected at 6.5 days post coitum (dpc) in the developing central nervous system (PubMed:17207666). At 7.75 dpc, expression is limited to the headfolds (PubMed:17207666). At 8 dpc, transcripts are detected in the midline neural groove (PubMed:17207666). Between 8 dpc and 9.5 dpc, it is found in the developing forebrain, brainstem, spinal cord, branchial arches, otic vesicles, midbrain and hindbrain folds (PubMed:17207666, PubMed:17353115). At 10.5 dpc, expression is detected in the telencephalic vesicles, branchial arches, otic vesicles, dorsal root ganglia, somites, spinal cord and forelimb buds, specifically in migratory muscle progenitor cells (PubMed:17207666). At 11.5 dpc, it is detected in telencephalic vesicles, midbrain-hindbrain boundary, the spinal cord, branchial arches, dorsal root ganglia, fore- and hindlimb buds and somites (PubMed:17207666, PubMed:17353115). Also detected at 11.5 dpc throughout the wall of the telencephalic vesicle and the medial and lateral ganglionic eminence (PubMed:17353115). At 14.5 dpc, expression is detected in the entire cerebral cortex, with higher levels in the developing hippocampus and septal area (PubMed:17207666). Expression becomes more graded by 16.5 and 18.5 dpc, where it is detected in the caudal and medial cerebral cortex, hippocampus and retrosplenial cortex (PubMed:17207666). Detected at 16.5 dpc in female genital tract (PubMed:17353115). It is also detected in the olfactory bud at 18.5 dpc (PubMed:17207666). Detected at 9.5 dpc in embryos (PubMed:20219459). Detected from 7.5 dpc in the brain, with highest levels of expression being detected at postnatal day 1 (PubMed:27621227). Expression remains at high levels at postnatal day 7 and begins to decrease by postnatal day 14 (PubMed:27621227). Expression is decreased further by postnatal day 30 (PubMed:27621227). Embryonic lethal (PubMed:27621227). Knockout mice do not develop past 18.5 days post coitum and exhibit smaller sized eyes with neural-tube defects (PubMed:27621227). Heterozygous mice exhibit decreased expression and delayed development (PubMed:27621227). Heterozygous mice grow slower, weigh less than wild-type mice and have significantly reduced brain weight (PubMed:27621227). They also exhibit lowered levels of PBX1 and HOXB8 (PubMed:27621227). Mice also exhibit anxiety-like behaviors with excessive grooming, resulting in gradual hair loss (PubMed:27621227). RNA polymerase II core promoter sequence-specific DNA binding nucleic acid binding DNA binding nucleus chromatin organization regulation of gene expression negative regulation of DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding histone methyltransferase complex uc008sxi.1 uc008sxi.2 uc008sxi.3 
ENSMUST00000098105.4 Cd72 ENSMUST00000098105.4 CD72 antigen, transcript variant 10 (from RefSeq NM_001419978.1) Cd72 ENSMUST00000098105.1 ENSMUST00000098105.2 ENSMUST00000098105.3 NM_001419978 Q3UNJ0 Q3UNJ0_MOUSE uc008spu.1 uc008spu.2 uc008spu.3 uc008spu.4 transmembrane signaling receptor activity integral component of plasma membrane membrane integral component of membrane uc008spu.1 uc008spu.2 uc008spu.3 uc008spu.4 
ENSMUST00000098109.10 Pigo ENSMUST00000098109.10 phosphatidylinositol glycan anchor biosynthesis, class O, transcript variant 8 (from RefSeq NR_186841.1) ENSMUST00000098109.1 ENSMUST00000098109.2 ENSMUST00000098109.3 ENSMUST00000098109.4 ENSMUST00000098109.5 ENSMUST00000098109.6 ENSMUST00000098109.7 ENSMUST00000098109.8 ENSMUST00000098109.9 NR_186841 Pigo Q562G0 Q562G0_MOUSE uc008sov.1 uc008sov.2 uc008sov.3 uc008sov.4 uc008sov.5 Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily. catalytic activity GPI anchor biosynthetic process membrane integral component of membrane transferase activity, transferring phosphorus-containing groups mannose-ethanolamine phosphotransferase activity uc008sov.1 uc008sov.2 uc008sov.3 uc008sov.4 uc008sov.5 
ENSMUST00000098110.3 AA474408 ENSMUST00000098110.3 AA474408 (from geneSymbol) AK132253 ENSMUST00000098110.1 ENSMUST00000098110.2 uc291ukm.1 uc291ukm.2 uc291ukm.1 uc291ukm.2 
ENSMUST00000098112.9 Dnajb5 ENSMUST00000098112.9 DnaJ heat shock protein family (Hsp40) member B5, transcript variant 5 (from RefSeq NM_001374168.1) Dnajb5 ENSMUST00000098112.1 ENSMUST00000098112.2 ENSMUST00000098112.3 ENSMUST00000098112.4 ENSMUST00000098112.5 ENSMUST00000098112.6 ENSMUST00000098112.7 ENSMUST00000098112.8 NM_001374168 Q3TY13 Q3TY13_MOUSE uc008som.1 uc008som.2 uc008som.3 cytosol protein folding response to unfolded protein unfolded protein binding chaperone binding uc008som.1 uc008som.2 uc008som.3 
ENSMUST00000098121.4 Il11ra3 ENSMUST00000098121.4 interleukin 11 receptor subunit alpha 3, transcript variant 2 (from RefSeq NM_001378674.1) A2RTL4 B1AXR8 ENSMUST00000098121.1 ENSMUST00000098121.2 ENSMUST00000098121.3 I11RB_MOUSE Il11ra2 NM_001378674 O09074 P70225 Q78DW8 uc008slo.1 uc008slo.2 uc008slo.3 Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. On ligand binding, forms a multimer complex with IL6ST/gp130. Membrane; Single-pass type I membrane protein. Expression restricted to testis, lymph node and thymus. Highest level in testis. Il11ra2 appears to arise through gene duplication of ancestral origin and has been lost in some inbred mouse strains. Belongs to the type I cytokine receptor family. Type 3 subfamily. cytokine receptor activity interleukin-11 receptor activity positive regulation of cell proliferation external side of plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway cytokine binding interleukin-11 binding interleukin-11-mediated signaling pathway receptor complex uc008slo.1 uc008slo.2 uc008slo.3 
ENSMUST00000098122.3 Ccl27al ENSMUST00000098122.3 C-C motif chemokine ligand 27A like, transcript variant 2 (from RefSeq NM_001164046.1) CCL27_MOUSE Ccl27 ENSMUST00000098122.1 ENSMUST00000098122.2 Ilc NM_001164046 Q3KNL1 Q9DAU6 Q9DAZ4 Q9Z1X0 Scya27 uc008sln.1 uc008sln.2 uc008sln.3 uc008sln.4 Chemotactic factor that attracts skin-associated memory T- lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10. Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization. Interacts with TNFAIP6 (via Link domain). [Isoform 1]: Secreted Nucleus Note=May also be nuclear when following receptor (CCR10)-mediated internalization. [Isoform 2]: Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z1X0-1; Sequence=Displayed; Name=2; Synonyms=PESKY; IsoId=Q9Z1X0-2; Sequence=VSP_001065; Isoform 1 is predominantly expressed in placenta and weakly in skin. Isoform 2 is predominantly expressed in testes and brain, weakly in kidney and liver and even lower in heart and muscle. Low expression of both isoforms in other tissues. Expressed during development. Belongs to the intercrine beta (chemokine CC) family. It is uncertain whether Met-1 or Met-2 is the initiator. Name=Wikipedia; Note=CCL27 entry; URL="https://en.wikipedia.org/wiki/CCL27"; cytokine activity protein binding extracellular region extracellular space nucleus immune response signal transduction chemokine activity positive regulation of T cell chemotaxis cell chemotaxis positive regulation of mononuclear cell migration positive regulation of actin cytoskeleton reorganization uc008sln.1 uc008sln.2 uc008sln.3 uc008sln.4 
ENSMUST00000098123.4 Ccl21f ENSMUST00000098123.4 C-C motif chemokine ligand 21F (from RefSeq NM_001193666.1) CC21C_MOUSE Ccl21c ENSMUST00000098123.1 ENSMUST00000098123.2 ENSMUST00000098123.3 NM_001193666 O09002 O09006 P84443 P86793 Q5M8M5 Q91V84 Scya21c uc008sll.1 uc008sll.2 uc008sll.3 Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to CCR7 and to CXCR3. Interacts with PDPN; relocalizes PDPN to the basolateral membrane. Interacts with GPR174. Secreted. Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart. Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while Ccl21a has 'Ser-65' (6Ckine-Ser). Belongs to the intercrine beta (chemokine CC) family. monocyte chemotaxis cytokine activity extracellular region extracellular space chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway chemokine activity neutrophil chemotaxis CCR7 chemokine receptor binding chemokine receptor binding positive regulation of GTPase activity CCR chemokine receptor binding lymphocyte chemotaxis cell chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor uc008sll.1 uc008sll.2 uc008sll.3 
ENSMUST00000098128.4 Ccl21d ENSMUST00000098128.4 C-C motif chemokine ligand 21D (from RefSeq NM_001270360.1) CC21C_MOUSE Ccl21c ENSMUST00000098128.1 ENSMUST00000098128.2 ENSMUST00000098128.3 NM_001270360 O09002 O09006 P84443 P86793 Q5M8M5 Q91V84 Scya21c uc008skt.1 uc008skt.2 uc008skt.3 Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to CCR7 and to CXCR3. Interacts with PDPN; relocalizes PDPN to the basolateral membrane. Interacts with GPR174. Secreted. Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart. Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while Ccl21a has 'Ser-65' (6Ckine-Ser). Belongs to the intercrine beta (chemokine CC) family. monocyte chemotaxis cytokine activity extracellular region extracellular space chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway chemokine activity neutrophil chemotaxis CCR7 chemokine receptor binding chemokine receptor binding positive regulation of GTPase activity CCR chemokine receptor binding lymphocyte chemotaxis cell chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor uc008skt.1 uc008skt.2 uc008skt.3 
ENSMUST00000098135.2 Rbmxl2 ENSMUST00000098135.2 RNA binding motif protein, X-linked-like 2 (from RefSeq NM_029660.2) ENSMUST00000098135.1 NM_029660 Q9DAE2 Q9DAE2_MOUSE Rbmxl2 uc009jay.1 uc009jay.2 nucleic acid binding RNA binding nucleus spliceosomal complex positive regulation of mRNA splicing, via spliceosome ribonucleoprotein complex uc009jay.1 uc009jay.2 
ENSMUST00000098143.11 Nfx1 ENSMUST00000098143.11 nuclear transcription factor, X-box binding 1, transcript variant 1 (from RefSeq NM_023739.3) B1AY10 ENSMUST00000098143.1 ENSMUST00000098143.10 ENSMUST00000098143.2 ENSMUST00000098143.3 ENSMUST00000098143.4 ENSMUST00000098143.5 ENSMUST00000098143.6 ENSMUST00000098143.7 ENSMUST00000098143.8 ENSMUST00000098143.9 NFX1_MOUSE NM_023739 Q3U2A7 Q3UK95 Q3UMW1 Q7TPT4 Q8CC59 Q9DBC8 Q9JKW7 uc008sie.1 uc008sie.2 uc008sie.3 uc008sie.4 Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2- dependent ubiquitination. Interacts with PABPC1 and PABPC4. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=B1AY10-1; Sequence=Displayed; Name=2; IsoId=B1AY10-2; Sequence=VSP_033694, VSP_033695; Name=3; IsoId=B1AY10-3; Sequence=VSP_033693, VSP_033696; Ubiquitously expressed, with highest levels in thymus. Ubiquitously expressed at 12 dpc and 14 dpc. The RING-type zinc finger domain interacts with an ubiquitin- conjugating enzyme (E2) and facilitates ubiquitination. Belongs to the NFX1 family. Sequence=AAF34700.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleolus cytosol plasma membrane regulation of transcription, DNA-templated zinc ion binding transferase activity negative regulation of MHC class II biosynthetic process metal ion binding uc008sie.1 uc008sie.2 uc008sie.3 uc008sie.4 
ENSMUST00000098152.3 Or52w1 ENSMUST00000098152.3 Membrane ; Multi- pass membrane protein (from UniProt Q7TRN5) BC119096 ENSMUST00000098152.1 ENSMUST00000098152.2 Olfr692 Or52w1 Q7TRN5 Q7TRN5_MOUSE uc009ixx.1 uc009ixx.2 uc009ixx.3 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ixx.1 uc009ixx.2 uc009ixx.3 
ENSMUST00000098155.3 Or56b34 ENSMUST00000098155.3 olfactory receptor family 56 subfamily B member 34 (from RefSeq NM_001011533.2) 56B34_MOUSE E9PVA1 ENSMUST00000098155.1 ENSMUST00000098155.2 NM_001011533 Olfr688 Or56b34 Q6W049 uc009ixt.1 uc009ixt.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Sequence=AAS99798.1; Type=Erroneous gene model prediction; Evidence=; G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ixt.1 uc009ixt.2 
ENSMUST00000098179.9 Trim5 ENSMUST00000098179.9 tripartite motif-containing 5 (from RefSeq NM_001310602.1) E9PV98 E9PV98_MOUSE ENSMUST00000098179.1 ENSMUST00000098179.2 ENSMUST00000098179.3 ENSMUST00000098179.4 ENSMUST00000098179.5 ENSMUST00000098179.6 ENSMUST00000098179.7 ENSMUST00000098179.8 NM_001310602 Trim5 uc291ttk.1 uc291ttk.2 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Cytoplasm Nucleus Belongs to the TRIM/RBCC family. P-body pattern recognition receptor signaling pathway ubiquitin-protein transferase activity cytoplasm autophagy zinc ion binding signaling pattern recognition receptor activity protein ubiquitination protein kinase binding protein binding, bridging identical protein binding protein homodimerization activity innate immune response metal ion binding defense response to virus omegasome uc291ttk.1 uc291ttk.2 
ENSMUST00000098180.10 Trim6 ENSMUST00000098180.10 tripartite motif-containing 6 (from RefSeq NM_001013616.2) B2RSQ8 ENSMUST00000098180.1 ENSMUST00000098180.2 ENSMUST00000098180.3 ENSMUST00000098180.4 ENSMUST00000098180.5 ENSMUST00000098180.6 ENSMUST00000098180.7 ENSMUST00000098180.8 ENSMUST00000098180.9 NM_001013616 Q8BGE7 Q99PQ6 TRIM6_MOUSE uc009ivq.1 uc009ivq.2 E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway (PubMed:24882218). In concert with the ubiquitin- conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response (PubMed:24882218). Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (PubMed:22328504). Promotes the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16 leading to enhancement of RIGI-mediated innate antiviral immune response (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homotrimer. Forms heteromultimers (via B30.2/SPRY domain) with TRIM5 (By similarity). Interacts with MYC (PubMed:22328504). Interacts (via SPRY domain) with IKBKE (By similarity). Interacts with VAMP8; this interaction contributes to the activation of the type I interferon antiviral response (By similarity). Interacts with DHX16 (By similarity). Cytoplasm The B-box zinc finger and the linker region between the coiled coil and B30.2/SPRY domains contribute to higher order self- association. Belongs to the TRIM/RBCC family. protein polyubiquitination positive regulation of defense response to virus by host positive regulation of cytokine secretion involved in immune response nucleus cytoplasm cytosol transcription factor binding zinc ion binding positive regulation of gene expression negative regulation of gene expression positive regulation of peptidyl-threonine phosphorylation free ubiquitin chain polymerization protein ubiquitination transferase activity protein kinase binding protein binding, bridging response to lipopolysaccharide positive regulation of peptidyl-serine phosphorylation cellular response to interferon-beta negative regulation of viral genome replication negative regulation of transcription, DNA-templated metal ion binding positive regulation of type I interferon-mediated signaling pathway ubiquitin protein ligase activity protein trimerization cellular response to virus protein tyrosine kinase binding positive regulation of transcription regulatory region DNA binding negative regulation of stem cell differentiation regulation of protein stability uc009ivq.1 uc009ivq.2 
ENSMUST00000098181.9 Pm20d2 ENSMUST00000098181.9 peptidase M20 domain containing 2, transcript variant 5 (from RefSeq NR_185084.1) A3KG59 Acy1l2 ENSMUST00000098181.1 ENSMUST00000098181.2 ENSMUST00000098181.3 ENSMUST00000098181.4 ENSMUST00000098181.5 ENSMUST00000098181.6 ENSMUST00000098181.7 ENSMUST00000098181.8 Gm424 NR_185084 P20D2_MOUSE Pm20d2 Q3ULU7 uc012dbj.1 uc012dbj.2 uc012dbj.3 uc012dbj.4 uc012dbj.5 Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus. Postulated to function in a metabolite repair mechanism by eliminating alternate dipeptide by-products formed during carnosine synthesis. Reaction=beta-alanyl-L-lysine + H2O = beta-alanine + L-lysine; Xref=Rhea:RHEA:59608, ChEBI:CHEBI:15377, ChEBI:CHEBI:32551, ChEBI:CHEBI:57966, ChEBI:CHEBI:143161; EC=3.4.13.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59609; Evidence=; Reaction=beta-alanyl-L-arginine + H2O = beta-alanine + L-arginine; Xref=Rhea:RHEA:59616, ChEBI:CHEBI:15377, ChEBI:CHEBI:32682, ChEBI:CHEBI:57966, ChEBI:CHEBI:143157; EC=3.4.13.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59617; Evidence=; Reaction=beta-alanyl-L-ornithine + H2O = beta-alanine + L-ornithine; Xref=Rhea:RHEA:59612, ChEBI:CHEBI:15377, ChEBI:CHEBI:46911, ChEBI:CHEBI:57966, ChEBI:CHEBI:143162; EC=3.4.13.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59613; Evidence=; Reaction=H2O + N(2)-(4-aminobutanoyl)-L-lysine = 4-aminobutanoate + L- lysine; Xref=Rhea:RHEA:59620, ChEBI:CHEBI:15377, ChEBI:CHEBI:32551, ChEBI:CHEBI:59888, ChEBI:CHEBI:143159; EC=3.4.13.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59621; Evidence=; Reaction=H2O + N(2)-(4-aminobutanoyl)-L-arginine = 4-aminobutanoate + L-arginine; Xref=Rhea:RHEA:59628, ChEBI:CHEBI:15377, ChEBI:CHEBI:32682, ChEBI:CHEBI:59888, ChEBI:CHEBI:143158; EC=3.4.13.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59629; Evidence=; Reaction=H2O + N(2)-(4-aminobutanoyl)-L-ornithine = 4-aminobutanoate + L-ornithine; Xref=Rhea:RHEA:59624, ChEBI:CHEBI:15377, ChEBI:CHEBI:46911, ChEBI:CHEBI:59888, ChEBI:CHEBI:143160; EC=3.4.13.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59625; Evidence=; Kinetic parameters: KM=1.9 mM for beta-alanyl-L-lysine ; KM=1.9 mM for beta-alanyl-L-ornithine ; KM=6.8 mM for beta-alanyl-L-arginine ; KM=2.6 mM for N(2)-(4-aminobutanoyl)-L-lysine ; KM=1.35 mM for N(2)-(4-aminobutanoyl)-L-ornithine ; Vmax=17.4 umol/min/mg enzyme toward beta-alanyl-L-lysine ; Vmax=30.7 umol/min/mg enzyme toward beta-alanyl-L-ornithine ; Vmax=27 umol/min/mg enzyme toward N(2)-(4-aminobutanoyl)-L-lysine ; Vmax=12.5 umol/min/mg enzyme toward N(2)-(4-aminobutanoyl)-L- ornithine ; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A3KG59-1; Sequence=Displayed; Name=2; IsoId=A3KG59-2; Sequence=VSP_025030, VSP_025031; Belongs to the peptidase M20A family. nucleoplasm proteolysis hydrolase activity dipeptidase activity regulation of cellular protein metabolic process cytoplasm folic acid catabolic process para-aminobenzoyl-glutamate hydrolase activity uc012dbj.1 uc012dbj.2 uc012dbj.3 uc012dbj.4 uc012dbj.5 
ENSMUST00000098190.10 Rragd ENSMUST00000098190.10 Ras-related GTP binding D, transcript variant 2 (from RefSeq NM_027491.2) B1AWT2 B1AWT2_MOUSE ENSMUST00000098190.1 ENSMUST00000098190.2 ENSMUST00000098190.3 ENSMUST00000098190.4 ENSMUST00000098190.5 ENSMUST00000098190.6 ENSMUST00000098190.7 ENSMUST00000098190.8 ENSMUST00000098190.9 NM_027491 Rragd uc008sfl.1 uc008sfl.2 uc008sfl.3 Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Cytoplasm Lysosome Belongs to the GTR/RAG GTP-binding protein family. GTPase activity GTP binding nucleus nucleoplasm cytoplasm lysosome centrosome GDP binding protein heterodimerization activity GTPase binding cellular response to leucine positive regulation of TORC1 signaling cellular response to leucine starvation uc008sfl.1 uc008sfl.2 uc008sfl.3 
ENSMUST00000098192.4 Hbb-bt ENSMUST00000098192.4 hemoglobin, beta adult t chain (from RefSeq NM_008220.5) A8DUK4 A8DUK4_MOUSE ENSMUST00000098192.1 ENSMUST00000098192.2 ENSMUST00000098192.3 Glna1 Hbb-bs Hbb-bt Hbbt1 Hbbt2 NM_008220 uc009iup.1 uc009iup.2 uc009iup.3 This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues. This gene is one of a cluster of beta-hemoglobin genes that are distally regulated by a locus control region, and which are organized along the chromosome in the order of their developmental expression. In mouse, two major strain-specific haplotypes of the beta-globin gene cluster are found - a 'single' haplotype found in C57BL/-type strains, which includes two highly similar adult beta-globin genes, beta s and beta t, and a 'diffuse' haplotype found in strains such as BALB/c and 129Sv, which includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This gene represents the beta t adult gene found in the 'single' haplotype. Primary chromosome 7 of the mouse reference genome assembly, which is derived from C57BL/6 strain mice, represents the 'single' haplotype, while the 'diffuse' haplotype is represented in the reference genome collection by the BALB/c strain alternate contig, NT_095534.1. [provided by RefSeq, May 2013]. CCDS Note: This gene represents the second of two adult-expressed beta-globin genes in the 'single' haplotype of the beta-globin cluster (PMID:7237554). The 'single' haplotype is found in C57BL/-type strains and includes two highly similar adult beta-globin genes, beta s and beta t, while the 'diffuse' haplotype is found in strains such as BALB/c and 129Sv, and includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This CCDS is based on primary chromosome 7 of the mouse reference genome assembly, which represents the 'single' haplotype. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Involved in oxygen transport from the lung to the various peripheral tissues. Belongs to the globin family. oxygen transporter activity extracellular space hemoglobin complex oxygen transport oxygen binding heme binding hemoglobin binding hemoglobin alpha binding hemoglobin beta binding haptoglobin-hemoglobin complex hydrogen peroxide catabolic process organic acid binding metal ion binding cellular oxidant detoxification peroxidase activity haptoglobin binding uc009iup.1 uc009iup.2 uc009iup.3 
ENSMUST00000098193.4 Or52a24 ENSMUST00000098193.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N6B2) ENSMUST00000098193.1 ENSMUST00000098193.2 ENSMUST00000098193.3 K7N6B2 K7N6B2_MOUSE Olfr628 Or52a24 uc291trq.1 uc291trq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291trq.1 uc291trq.2 
ENSMUST00000098195.3 Or52z15 ENSMUST00000098195.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A140T8L4) A0A140T8L4 A0A140T8L4_MOUSE ENSMUST00000098195.1 ENSMUST00000098195.2 Olfr625 Or52z15 uc291trl.1 uc291trl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291trl.1 uc291trl.2 
ENSMUST00000098211.2 Or51f1d ENSMUST00000098211.2 olfactory receptor family 51 subfamily F member 1D (from RefSeq NM_146757.1) ENSMUST00000098211.1 NM_146757 Olfr566 Olfr583 Or51f1d Q8VG25 Q8VG25_MOUSE uc009itb.1 uc009itb.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009itb.1 uc009itb.2 
ENSMUST00000098213.8 Or51a7 ENSMUST00000098213.8 olfactory receptor family 51 subfamily A member 7 (from RefSeq NM_001001805.2) A0A0G2JFH3 A0A0G2JFH3_MOUSE ENSMUST00000098213.1 ENSMUST00000098213.2 ENSMUST00000098213.3 ENSMUST00000098213.4 ENSMUST00000098213.5 ENSMUST00000098213.6 ENSMUST00000098213.7 NM_001001805 Olfr576 Or51a7 uc009isx.1 uc009isx.2 uc009isx.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC106977.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009isx.1 uc009isx.2 uc009isx.3 
ENSMUST00000098216.2 Or51f2 ENSMUST00000098216.2 olfactory receptor family 51 subfamily F member 2 (from RefSeq NM_147091.2) E9Q554 E9Q554_MOUSE ENSMUST00000098216.1 NM_147091 Olfr568 Or51f2 uc009isq.1 uc009isq.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009isq.1 uc009isq.2 
ENSMUST00000098220.2 Or51h1 ENSMUST00000098220.2 olfactory receptor family 51 subfamily H member 1 (from RefSeq NM_147103.2) E9Q547 E9Q547_MOUSE ENSMUST00000098220.1 NM_147103 Olfr555 Or51h1 uc009isd.1 uc009isd.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC106981.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009isd.1 uc009isd.2 
ENSMUST00000098229.3 Or52b4 ENSMUST00000098229.3 olfactory receptor family 52 subfamily B member 4 (from RefSeq NM_147079.2) E9PXN3 E9PXN3_MOUSE E9Q536 ENSMUST00000098229.1 ENSMUST00000098229.2 NM_147079 Olfr547 Olfr548-ps1 Or52b4 uc009iru.1 uc009iru.2 uc009iru.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the same strain was available for the full length of the gene. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane cognition response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009iru.1 uc009iru.2 uc009iru.3 
ENSMUST00000098230.11 Rhog ENSMUST00000098230.11 ras homolog family member G (from RefSeq NM_019566.3) ENSMUST00000098230.1 ENSMUST00000098230.10 ENSMUST00000098230.2 ENSMUST00000098230.3 ENSMUST00000098230.4 ENSMUST00000098230.5 ENSMUST00000098230.6 ENSMUST00000098230.7 ENSMUST00000098230.8 ENSMUST00000098230.9 NM_019566 Q3UDZ1 Q3UDZ1_MOUSE Rhog uc009irk.1 uc009irk.2 uc009irk.3 nucleotide binding GTPase activity GTP binding small GTPase mediated signal transduction Rho protein signal transduction Rac protein signal transduction actin cytoskeleton organization positive regulation of transcription, DNA-templated cell chemotaxis activation of GTPase activity positive regulation of protein localization to plasma membrane uc009irk.1 uc009irk.2 uc009irk.3 
ENSMUST00000098242.4 Ggh ENSMUST00000098242.4 gamma-glutamyl hydrolase (from RefSeq NM_010281.2) B1AWC1 ENSMUST00000098242.1 ENSMUST00000098242.2 ENSMUST00000098242.3 GGH_MOUSE NM_010281 Q9Z0L7 Q9Z0L8 uc008sck.1 uc008sck.2 uc008sck.3 Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Reaction=(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate; Xref=Rhea:RHEA:56784, Rhea:RHEA-COMP:14738, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:57453, ChEBI:CHEBI:141005; EC=3.4.19.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56785; Evidence=; Homodimer. Secreted, extracellular space Lysosome Melanosome Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Event=Alternative splicing; Named isoforms=2; Name=I; IsoId=Q9Z0L8-1; Sequence=Displayed; Name=II; IsoId=Q9Z0L8-2; Sequence=VSP_005447; Isoform I (more expressed than isoform II in all tissues) is highly expressed in salivary gland, followed by kidney, liver, lung, stomach and uterus, and weakly expressed in small intestine, brain and fetal liver. Also expressed at a lower level in thymus, spleen and skeletal muscle. Also expressed in tumors. Belongs to the peptidase C26 family. extracellular region extracellular space lysosome vacuole cytosol proteolysis omega peptidase activity response to zinc ion hydrolase activity response to insulin gamma-glutamyl-peptidase activity melanosome response to drug response to ethanol tetrahydrofolylpolyglutamate metabolic process uc008sck.1 uc008sck.2 uc008sck.3 
ENSMUST00000098244.2 Ttpa ENSMUST00000098244.2 tocopherol (alpha) transfer protein, transcript variant 1 (from RefSeq NM_015767.5) ENSMUST00000098244.1 NM_015767 Q8BWP5 Q9CW51 Q9JL07 TTPA_MOUSE uc008scj.1 uc008scj.2 uc008scj.3 uc008scj.4 Binds (+)-alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol. Monomer and homotetramer. Phosphatidylinositol 4,5- bisphosphate binding induces the formation of homotetramers. Phosphatidylinositol 3,4-bisphosphate is less efficient in inducing tetramerization. Cytoplasm placenta development embryonic placenta development phosphatidylinositol-4,5-bisphosphate binding cytoplasm late endosome cytosol response to nutrient lipid binding vitamin E binding response to pH response to toxic substance vitamin binding developmental process vitamin E metabolic process phosphatidylinositol-3,4-bisphosphate binding vitamin transport intracellular pH reduction negative regulation of cell death negative regulation of establishment of blood-brain barrier uc008scj.1 uc008scj.2 uc008scj.3 uc008scj.4 
ENSMUST00000098250.10 Fchsd2 ENSMUST00000098250.10 FCH and double SH3 domains 2, transcript variant 4 (from RefSeq NM_001420353.1) ENSMUST00000098250.1 ENSMUST00000098250.2 ENSMUST00000098250.3 ENSMUST00000098250.4 ENSMUST00000098250.5 ENSMUST00000098250.6 ENSMUST00000098250.7 ENSMUST00000098250.8 ENSMUST00000098250.9 FCSD2_MOUSE Kiaa0769 NM_001420353 Q3UQZ2 Q3USJ8 Q6P9R0 Q80TS2 Sh3md3 uc009iod.1 uc009iod.2 uc009iod.3 uc009iod.4 Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (By similarity). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex (PubMed:23437151). Does not promote actin polymerisation in the absence of membranes (By similarity). Homodimer (Probable). Interacts (via SH3 domain 2) with ITSN1 (via SH3 domain 4). Recruited to clathrin-coated pits during a mid-to- late stage of assembly via interaction with ITSN1 (By similarity). Interacts (via SH3 domain 1) with WASL (PubMed:23437151, PubMed:29887380). Interacts with WAS (PubMed:23437151). Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1 (By similarity). Cytoplasm Cell junction Membrane, clathrin-coated pit Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, stereocilium Note=Partially localized at clathrin- coated pits at the cell membrane. Detected at the cell membrane at sites around clathrin-coated pits, very close to the clathrin-coated pits but not an intrinsic part of the clathrin-coated pits. Colocalizes at cell-cell contacts with CDH1, but is not detected at tight junctions. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3USJ8-1; Sequence=Displayed; Name=2; IsoId=Q3USJ8-2; Sequence=VSP_023171; Name=3; IsoId=Q3USJ8-3; Sequence=VSP_023170, VSP_023171; Detected in inner ear vestibula and in stereocilia in cochlear hair cell bundles (at protein level). Ubiquitous. Detected in testis, liver, brain cortex, cerebellum, kidney, organ of Corti, utricle, spiral ganglion, tongue and eye. Detected in brain cortex at 15.5 dpc and in neonates, but levels decrease 16.5 days after birth and are very low in adult brain cortex (at protein level). The F-BAR domain has an atypical, flat shape and binds preferentially to flat membranes (By similarity). Upon heterologous expression, the isolated F-BAR domain is localized at the cell membrane, and causes the formation of cellular protrusions (PubMed:23761074, PubMed:26686642). Recruited to clathrin-coated pits via SH3 domain 2. The two SH3 domains cooperate to maintain the protein in an autoinhibited conformation that prevents promiscuous membrane binding. Phosphorylated. Phosphorylation on a Ser residue is important for recruitment to the cell membrane and for its role in promoting endocytosis. Sequence=BAC65650.1; Type=Erroneous initiation; Evidence=; protein binding phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm plasma membrane clathrin-coated pit endocytosis neuromuscular synaptic transmission lipid binding protein transport membrane cell junction regulation of actin filament polymerization positive regulation of actin filament polymerization neuromuscular junction stereocilium cell projection phosphatidylinositol-3,4-bisphosphate binding multi-organism membrane organization recycling endosome clathrin-dependent endocytosis positive regulation of Arp2/3 complex-mediated actin nucleation uc009iod.1 uc009iod.2 uc009iod.3 uc009iod.4 
ENSMUST00000098256.4 Runx1t1 ENSMUST00000098256.4 RUNX1 translocation partner 1, transcript variant 3 (from RefSeq NM_009822.3) Cbfa2t1 Cbfa2t1h ENSMUST00000098256.1 ENSMUST00000098256.2 ENSMUST00000098256.3 MTG8_MOUSE Mtg8 NM_009822 Q61909 uc008sax.1 uc008sax.2 uc008sax.3 uc008sax.4 uc008sax.5 uc008sax.6 Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12 (By similarity). Acts as a negative regulator of adipogenesis (PubMed:23527555). Homotetramer (By similarity). Heterotetramer with CBFA2T2 and CBFA2T3 (By similarity). Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression (By similarity). Nucleus Note=Colocalizes with ATN1 in discrete nuclear dots. The TAFH domain mediates interaction with transcription regulators. Nervy homology region 2 (NHR2) mediates homo- and possibly heterotypic oligomerization by forming a four-helix bundle tetrameric structure. Belongs to the CBFA2T family. transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus nucleoplasm regulation of transcription, DNA-templated negative regulation of neuron projection development nuclear matrix transcriptional repressor complex protein homodimerization activity fat cell differentiation negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated metal ion binding regulation of DNA binding DNA binding uc008sax.1 uc008sax.2 uc008sax.3 uc008sax.4 uc008sax.5 uc008sax.6 
ENSMUST00000098266.9 Arrb1 ENSMUST00000098266.9 arrestin, beta 1, transcript variant a (from RefSeq NM_177231.2) ARRB1_MOUSE ENSMUST00000098266.1 ENSMUST00000098266.2 ENSMUST00000098266.3 ENSMUST00000098266.4 ENSMUST00000098266.5 ENSMUST00000098266.6 ENSMUST00000098266.7 ENSMUST00000098266.8 NM_177231 Q3UH95 Q8BTJ5 Q8BWG8 uc009ilu.1 uc009ilu.2 uc009ilu.3 Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin- mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand- activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2- mediated activation (reciprocal regulation). Is required for SP- stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1- mediated ERK activity. Acts as a signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1- mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1- mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF- kappa-B and JUN. Involved in IL8-mediated granule release in neutrophils. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3 (By similarity). Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. Participates in the recruitment of the ubiquitin- protein ligase to the receptor (PubMed:23886940). Monomer. Homodimer. Homooligomer; the self-association is mediated by InsP6-binding. Heterooligomer with ARRB2; the association is mediated by InsP6-binding. Interacts with ADRB2 (phosphorylated). Interacts with CHRM2 (phosphorylated). Interacts with LHCGR. Interacts with CYTH2 and CASR. Interacts with AP2B1 (dephosphorylated); phosphorylation of AP2B1 disrupts the interaction. Interacts (dephosphorylated at Ser-412) with CLTC. Interacts with CCR2 and GRK2. Interacts with CRR5. Interacts with PTAFR (phosphorylated on serine residues). Interacts with CLTC and MAP2K3. Interacts with CREB1. Interacts with TRAF6. Interacts with IGF1R and MDM2. Interacts with C5AR1. Interacts with PDE4D. Interacts with SRC (via the SH3 domain and the protein kinase domain); the interaction is independent of the phosphorylation state of SRC C-terminus. Interacts with TACR1. Interacts with RAF1. Interacts with DVL1; the interaction is enhanced by phosphorylation of DVL1. Interacts with DVL2; the interaction is enhanced by phosphorylation of DVL2. Interacts with IGF1R. Interacts with CHUK, IKBKB and MAP3K14. Associates with MAP kinase p38. Part of a MAPK signaling complex consisting of TACR1, ARRB1, SRC, MAPK1 (activated) and MAPK3 (activated). Part of a MAPK signaling complex consisting of F2RL1, ARRB1, RAF1, MAPK1 (activated) and MAPK3 (activated). Interacts with GPR143 (By similarity). Interacts with MAP2K4/MKK4. Interacts with HCK and CXCR1 (phosphorylated) (By similarity). Interacts with ACKR3 and ACKR4 (By similarity). Interacts with ARRDC1; the interaction is direct (PubMed:23886940). Interacts with GPR61, GPR62 and GPR135 (By similarity). Q8BWG8; P58660: Card10; NbExp=4; IntAct=EBI-641778, EBI-8344379; Q8BWG8; O54946: Dnajb6; NbExp=6; IntAct=EBI-641778, EBI-642500; Q8BWG8; O35387: Hax1; NbExp=6; IntAct=EBI-641778, EBI-642449; Q8BWG8; P23804: Mdm2; NbExp=4; IntAct=EBI-641778, EBI-641788; Q8BWG8; Q60795: Nfe2l2; NbExp=4; IntAct=EBI-641778, EBI-642563; Cytoplasm Nucleus Cell membrane Membrane, clathrin-coated pit Cell projection, pseudopodium Cytoplasmic vesicle Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1A; IsoId=Q8BWG8-1; Sequence=Displayed; Name=1B; IsoId=Q8BWG8-2; Sequence=VSP_019545; The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1. Binding to phosphorylated GPCRs induces a conformationanl change that exposes the motif to the surface (By similarity). The N-terminus binds InsP6 with low affinity. The C-terminus binds InsP6 with high affinity. Constitutively phosphorylated at in the cytoplasm. At the plasma membrane, is rapidly dephosphorylated, a process that is required for clathrin binding and ADRB2 endocytosis but not for ADRB2 binding and desensitization. Once internalized, is rephosphorylated (By similarity). The ubiquitination status appears to regulate the formation and trafficking of beta-arrestin-GPCR complexes and signaling. Ubiquitination appears to occur GPCR-specific. Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2. Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex. Stimulation of a class A GPCR, such as ADRB2, induces transient ubiquitination and subsequently promotes association with USP33 (By similarity). Belongs to the arrestin family. activation of MAPK activity chromatin G-protein coupled receptor binding negative regulation of protein phosphorylation positive regulation of protein phosphorylation G-protein coupled receptor internalization positive regulation of receptor internalization GTPase activator activity receptor binding insulin-like growth factor receptor binding protein binding nucleus nucleoplasm cytoplasm endosome cytosol plasma membrane clathrin-coated pit transcription from RNA polymerase II promoter ubiquitin-dependent protein catabolic process endocytosis apoptotic process signal transduction G-protein coupled receptor signaling pathway phototransduction transcription factor binding regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation negative regulation of signal transduction postsynaptic density protein transport membrane basolateral plasma membrane protein ubiquitination nuclear body enzyme binding clathrin binding estrogen receptor binding pseudopodium negative regulation of protein ubiquitination positive regulation of protein ubiquitination cytoplasmic vesicle mitogen-activated protein kinase kinase binding ubiquitin protein ligase binding alpha-1A adrenergic receptor binding alpha-1B adrenergic receptor binding angiotensin receptor binding follicle-stimulating hormone receptor binding V2 vasopressin receptor binding negative regulation of NF-kappaB transcription factor activity positive regulation of protein binding negative regulation of interleukin-6 production negative regulation of interleukin-8 production positive regulation of peptidyl-serine phosphorylation negative regulation of GTPase activity positive regulation of smooth muscle cell apoptotic process positive regulation of Rho protein signal transduction positive regulation of histone acetylation AP-2 adaptor complex binding clathrin adaptor activity positive regulation of insulin secretion involved in cellular response to glucose stimulus response to drug follicle-stimulating hormone signaling pathway regulation of apoptotic process cell projection cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process stress fiber assembly negative regulation of cysteine-type endopeptidase activity involved in apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process dendritic spine positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of neuron apoptotic process positive regulation of GTPase activity transcription regulatory region DNA binding ion channel binding postsynaptic membrane protein phosphorylated amino acid binding negative regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter phosphoprotein binding negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of histone H4 acetylation arrestin family protein binding uc009ilu.1 uc009ilu.2 uc009ilu.3 
ENSMUST00000098272.4 Klhl40 ENSMUST00000098272.4 kelch-like 40 (from RefSeq NM_028202.3) A0A0R4J166 A0A0R4J166_MOUSE ENSMUST00000098272.1 ENSMUST00000098272.2 ENSMUST00000098272.3 Klhl40 NM_028202 uc009sdv.1 uc009sdv.2 uc009sdv.3 uc009sdv.4 Cytoplasm, myofibril, sarcomere, A band Cytoplasm, myofibril, sarcomere, I band Belongs to the KLHL40 family. negative regulation of protein ubiquitination skeletal muscle fiber development uc009sdv.1 uc009sdv.2 uc009sdv.3 uc009sdv.4 
ENSMUST00000098278.4 B3gnt6 ENSMUST00000098278.4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (from RefSeq NM_001081167.1) B3GN6_MOUSE ENSMUST00000098278.1 ENSMUST00000098278.2 ENSMUST00000098278.3 NM_001081167 Q3USF0 uc009ikf.1 uc009ikf.2 uc009ikf.3 Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs. Reaction=3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl- (1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:46880, Rhea:RHEA-COMP:11689, Rhea:RHEA- COMP:11692, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:87075, ChEBI:CHEBI:87080; EC=2.4.1.147; Evidence=; Reaction=3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP- N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl- (1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:46884, Rhea:RHEA-COMP:11691, Rhea:RHEA- COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:53604, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:87079; EC=2.4.1.147; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 31 family. Golgi membrane endoplasmic reticulum Golgi apparatus protein glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups poly-N-acetyllactosamine biosynthetic process acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity uc009ikf.1 uc009ikf.2 uc009ikf.3 
ENSMUST00000098281.4 Omp ENSMUST00000098281.4 olfactory marker protein (from RefSeq NM_011010.2) ENSMUST00000098281.1 ENSMUST00000098281.2 ENSMUST00000098281.3 NM_011010 OMP_MOUSE Q64288 uc009ike.1 uc009ike.2 uc009ike.3 May act as a modulator of the olfactory signal-transduction cascade. Interacts with BEX1 and BEX2. Cytoplasm Uniquely associated with mature olfactory receptor neurons. Belongs to the olfactory marker protein family. nucleus cytoplasm cytosol signal transduction sensory perception of smell neurogenesis axon peptide binding neuronal cell body response to stimulus uc009ike.1 uc009ike.2 uc009ike.3 
ENSMUST00000098300.6 Alg8 ENSMUST00000098300.6 ALG8 alpha-1,3-glucosyltransferase (from RefSeq NM_199035.2) ALG8_MOUSE Alg8 E9Q3H5 ENSMUST00000098300.1 ENSMUST00000098300.2 ENSMUST00000098300.3 ENSMUST00000098300.4 ENSMUST00000098300.5 Gm1089 NM_199035 Q3TKP5 Q6P8H8 uc009ijc.1 uc009ijc.2 uc009ijc.3 uc009ijc.4 uc009ijc.5 Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol before it is transferred to the nascent peptide (By similarity). Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the primary cilia (PubMed:28375157). Reaction=a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)- alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D- Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man- (1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D- Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)- alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D- Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+); Xref=Rhea:RHEA:31307, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9528, Rhea:RHEA-COMP:12632, Rhea:RHEA-COMP:12633, ChEBI:CHEBI:15378, ChEBI:CHEBI:57525, ChEBI:CHEBI:57683, ChEBI:CHEBI:132521, ChEBI:CHEBI:132522; EC=2.4.1.265; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the ALG6/ALG8 glucosyltransferase family. alpha-1,3-mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation protein N-linked glycosylation oligosaccharide-lipid intermediate biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups protein N-linked glycosylation via asparagine dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity mannosylation uc009ijc.1 uc009ijc.2 uc009ijc.3 uc009ijc.4 uc009ijc.5 
ENSMUST00000098303.3 Gm9934 ENSMUST00000098303.3 Gm9934 (from geneSymbol) AK079653 ENSMUST00000098303.1 ENSMUST00000098303.2 uc291ssd.1 uc291ssd.2 uc291ssd.1 uc291ssd.2 
ENSMUST00000098312.4 Exoc8 ENSMUST00000098312.4 exocyst complex component 8 (from RefSeq NM_198103.2) ENSMUST00000098312.1 ENSMUST00000098312.2 ENSMUST00000098312.3 EXOC8_MOUSE NM_198103 Q6PGF7 uc009nxw.1 uc009nxw.2 uc009nxw.3 Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts (via PH domain) with GTP-bound RALA and RALB (By similarity). Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (By similarity). Cytoplasm Cytoplasm, perinuclear region Cell projection, growth cone Cell projection Note=Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity). Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during NGF-induced neuronal differentiation (By similarity). Localizes at the leading edge of migrating cells (By similarity). Belongs to the EXO84 family. exocyst cytoplasm late endosome cytosol plasma membrane exocytosis Golgi to plasma membrane transport endosome organization protein localization protein transport Ral GTPase binding extracellular matrix disassembly growth cone cell leading edge cellular protein localization phosphatidylinositol binding cell projection perinuclear region of cytoplasm uc009nxw.1 uc009nxw.2 uc009nxw.3 
ENSMUST00000098324.4 Mc1r ENSMUST00000098324.4 melanocortin 1 receptor (from RefSeq NM_008559.3) ENSMUST00000098324.1 ENSMUST00000098324.2 ENSMUST00000098324.3 MSHR_MOUSE Msh-r NM_008559 Q01727 Q75NA3 uc009nvs.1 uc009nvs.2 uc009nvs.3 uc009nvs.4 Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:1325670). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1325670). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (By similarity). Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity melanocortin receptor activity melanocyte-stimulating hormone receptor activity protein binding plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of protein kinase A signaling membrane integral component of membrane sensory perception of pain ubiquitin protein ligase binding negative regulation of tumor necrosis factor production intracellular signal transduction melanin biosynthetic process hormone binding pigmentation positive regulation of transcription from RNA polymerase II promoter positive regulation of protein kinase B signaling regulation of feeding behavior UV-damage excision repair positive regulation of protein kinase C signaling positive regulation of feeding behavior uc009nvs.1 uc009nvs.2 uc009nvs.3 uc009nvs.4 
ENSMUST00000098331.10 Cpeb1 ENSMUST00000098331.10 cytoplasmic polyadenylation element binding protein 1, transcript variant 2 (from RefSeq NM_007755.5) CPEB1_MOUSE Cpeb ENSMUST00000098331.1 ENSMUST00000098331.2 ENSMUST00000098331.3 ENSMUST00000098331.4 ENSMUST00000098331.5 ENSMUST00000098331.6 ENSMUST00000098331.7 ENSMUST00000098331.8 ENSMUST00000098331.9 NM_007755 P70166 Q8C5P9 uc009ibw.1 uc009ibw.2 uc009ibw.3 Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress (By similarity). Required for cell cycle progression, specifically for prophase entry (By similarity). Interacts with kinesin, dynein, APLP1, APLP2, TENT2/GLD2 and APP. Both phosphorylated and non phosphorylated forms interact with APLP1 (PubMed:12629046, PubMed:16314516, PubMed:16705177, PubMed:17927953). Interacts with TENT4B; the interaction is required for TENT4B-mediated translational control (By similarity). Cytoplasm Synapse Cytoplasm, P-body Cytoplasmic granule Membrane Postsynaptic density Note=Localizes in synaptosomes at dendritic synapses of neurons. Strongly enriched in postsynaptic density (PSD) fractions. Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin. Membrane- associated. Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs. In P-bodies and stress granules (By similarity). Recruited to stress granules (SGs) upon arsenite treatment (By similarity). Expressed in hippocampus, cerebral cortex and oocytes (at protein level). Expressed in brain, heart, kidney, lung and ovary and testis. Weakly expressed in granular cells of dentate gyrus and the pyramidal cells of CA3 and CA1 of the hippocampus. Expressed in embryonic ovaries at 14.5, 16.5 and 18.5 dpc (at protein level). Not induced by kainate. The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA. The interdomain linker (411-429) acts as a hinge to fix the relative orientation of the 2 RRMs. The ZZ domain (509-566) coordinates 2 Zn ions and is probably implicated in mediating interactions with other proteins in addition to increasing the affinity of the RRMs for the CPEs. A continuous hydrophobic interface is formed between the 2 RRM. Phosphorylated on serine/threonine residues by AURKA within positions 165 and 196 (By similarity). Phosphorylation and dephosphorylation on Thr-171 regulates cytoplasmic polyadenylation and translation of CPE-containing mRNAs. Phosphorylation on Thr-171 by AURKA in embryonic ovaries at 16.5 dpc (mostly pachytene oocytes) activates CPEB1. Not phosphorylated on Thr-171 in embryonic ovaries between 18.5 dpc (diplotene oocytes) and metaphase I. Dephosphorylation on Thr-171 by PP1 in embryonic ovaries at 18.5 dpc (mostly diplotene oocytes) inactivates CPEB1. In maturing oocytes, re-phosphorylation on Thr-171 by AURKA reactivates CPEB1. Phosphorylation on Thr-171 by CAMK2A in depolarized hippocampal neurons activates CPEB1. Dephosphorylation on Thr-171 (indirectly by PP1) in hippocampal neurons inactivates CPEB1. Phosphorylation on Thr-171 may be promoted by APLP1. Phosphorylation increases binding to RNA. Belongs to the RRM CPEB family. translation repressor activity, nucleic acid binding P-body nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding nucleus nucleoplasm cytoplasm centrosome cytosol plasma membrane mRNA processing translation regulation of translation synaptonemal complex assembly translation factor activity, RNA binding negative regulation of cell proliferation positive regulation of neuron projection development postsynaptic density membrane negative regulation of translation cell junction positive regulation of cell migration growth cone cellular response to insulin stimulus mRNA 3'-UTR AU-rich region binding neuron projection ribosome binding neuronal cell body translation regulator activity synapse postsynaptic membrane positive regulation of translation metal ion binding regulation of neuronal synaptic plasticity perinuclear region of cytoplasm mRNA transport positive regulation of nitric-oxide synthase biosynthetic process cellular response to amino acid stimulus cellular response to hypoxia meiotic spindle positive regulation of mRNA polyadenylation messenger ribonucleoprotein complex negative regulation of cytoplasmic translation uc009ibw.1 uc009ibw.2 uc009ibw.3 
ENSMUST00000098333.5 Ankrd11 ENSMUST00000098333.5 Ankrd11 (from geneSymbol) Ankrd11 BC158043 E9Q4F8 E9Q4F8_MOUSE ENSMUST00000098333.1 ENSMUST00000098333.2 ENSMUST00000098333.3 ENSMUST00000098333.4 uc292dul.1 uc292dul.2 uc292dul.1 uc292dul.2 
ENSMUST00000098340.7 Lrrfip2 ENSMUST00000098340.7 leucine rich repeat (in FLII) interacting protein 2, transcript variant 2 (from RefSeq NM_027742.3) A0A0R4J169 A0A0R4J169_MOUSE ENSMUST00000098340.1 ENSMUST00000098340.2 ENSMUST00000098340.3 ENSMUST00000098340.4 ENSMUST00000098340.5 ENSMUST00000098340.6 Lrrfip2 NM_027742 uc009rvm.1 uc009rvm.2 uc009rvm.3 uc009rvm.4 Belongs to the LRRFIP family. regulation of transcription, DNA-templated uc009rvm.1 uc009rvm.2 uc009rvm.3 uc009rvm.4 
ENSMUST00000098345.3 Prss44 ENSMUST00000098345.3 serine protease 44 (from RefSeq NM_148940.3) ENSMUST00000098345.1 ENSMUST00000098345.2 NM_148940 PRS44_MOUSE Prss44 Q402U7 Q924U6 Tessp4 uc009rut.1 uc009rut.2 uc009rut.3 Lacks protease activity in vitro. Membrane ; Single-pass membrane protein Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q402U7-1; Sequence=Displayed; Name=2; IsoId=Q402U7-2; Sequence=VSP_041974, VSP_041975; Testis-specific (PubMed:23536369). Expressed by primary and secondary spermatocytes (PubMed:23536369). In testis, expressed at all stages from the late pachytene primary spermatocyte to the secondary spermatocyte. Not detected at day 7 after birth. Expression is detected at day 14 and increases dramatically at day 21 and reach a peak at day 28 to remain high until day 56. Belongs to the peptidase S1 family. Lacks protease activity in vitro. serine-type endopeptidase activity extracellular space cytoplasm proteolysis germ cell development spermatogenesis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc009rut.1 uc009rut.2 uc009rut.3 
ENSMUST00000098346.5 Man2a2 ENSMUST00000098346.5 mannosidase 2, alpha 2 (from RefSeq NM_172903.4) ENSMUST00000098346.1 ENSMUST00000098346.2 ENSMUST00000098346.3 ENSMUST00000098346.4 MA2A2_MOUSE Mana2x NM_172903 Q3UVK1 Q8BRK9 uc009iap.1 uc009iap.2 uc009iap.3 Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity). Reaction=2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha- D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man- (1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man- (1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc}-L-asparaginyl-[protein]; Xref=Rhea:RHEA:56052, Rhea:RHEA-COMP:14368, Rhea:RHEA-COMP:14369, ChEBI:CHEBI:15377, ChEBI:CHEBI:28729, ChEBI:CHEBI:60615, ChEBI:CHEBI:60625; EC=3.2.1.114; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Protein modification; protein glycosylation. Homodimer; disulfide-linked (By similarity). Interacts with MGAT4D. Golgi apparatus membrane ; Single- pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BRK9-1; Sequence=Displayed; Name=2; IsoId=Q8BRK9-2; Sequence=VSP_041735, VSP_041736; Belongs to the glycosyl hydrolase 38 family. Golgi membrane catalytic activity alpha-mannosidase activity mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity Golgi apparatus carbohydrate metabolic process mannose metabolic process protein glycosylation N-glycan processing protein deglycosylation metabolic process mannosidase activity membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing N-glycosyl compounds carbohydrate binding metal ion binding uc009iap.1 uc009iap.2 uc009iap.3 
ENSMUST00000098350.10 Scap ENSMUST00000098350.10 SREBF chaperone, transcript variant 3 (from RefSeq NM_001410582.1) ENSMUST00000098350.1 ENSMUST00000098350.2 ENSMUST00000098350.3 ENSMUST00000098350.4 ENSMUST00000098350.5 ENSMUST00000098350.6 ENSMUST00000098350.7 ENSMUST00000098350.8 ENSMUST00000098350.9 Kiaa0199 NM_001410582 Q6A0A6 Q6GQT6 Q6NS67 Q7TNG7 Q80UI6 SCAP_MOUSE Scap uc009rtx.1 uc009rtx.2 uc009rtx.3 uc009rtx.4 uc009rtx.5 Escort protein required for cholesterol as well as lipid homeostasis (PubMed:11358865, PubMed:9854040). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:11358865, PubMed:9854040, PubMed:29068315). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity). Binds cholesterol via its SSD domain (By similarity). Membrane region forms a homotetramer. Component of the SCAP- SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); interacts with SREBF1/SREBP1 or SREBF2/SREBP2 through its C-terminal cytoplasmic domain. Forms a ternary complex with INSIG1 or INSIG2 through its transmembrane domains at high sterol concentrations. Interacts with the SEC23-SEC24 complex in a SAR1-GTP-dependent manner through an ER export signal in its third cytoplasmic loop (By similarity). Interacts with RNF139; the interaction inhibits the interaction of SCAP with SEC24B and hampering the ER to Golgi transport of the SCAP-SREBP complex. Interacts with SPRING1 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasmic vesicle, COPII- coated vesicle membrane ; Multi-pass membrane protein Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. Requires the presence of SPRING for proper localization to endoplasmic reticulum. Loop-1 binds to loop-7, enabling interaction with COPII-coated vesicles. When levels of cholesterol in the endoplasmic reticulum increase, Loop-1 binds to cholesterol instead, thereby disrupting direct binding between the two loops and preventing the SCAP-SREBP complex from exiting the endoplasmic reticulum. Cholesterol bound to SSD domain of SCAP or oxysterol bound to INSIG (INSIG1 or INSIG2) leads to masking of an ER export signal (also named MELADL motif) on SCAP possibly by moving the signal further away from the ER membrane. Ubiquitinated at Lys-454 and Lys-466. RNF145 triggers ubiquitination of SCAP, likely inhibiting SCAP-SREBP complex transport to the Golgi apparatus and the subsequent processing/maturation of SREBF2/SREBP2. Mice lacking Scap in their liver show an 80% reduction in cholesterol and fatty acid synthesis in the liver as well as a lack of regulation of target gene expression in response to cholesterol deprivation or insulin elevation. Mice expressing dominant negative mutant Scap in their liver show higher levels of mature Srebf1 and Srebf2 as well as transcripts encoding proteins involved in uptake and synthesis of cholesterol and fatty acids. They show an 1.6-fold increase in liver size as well as a six-fold increase in cholesterol and a nine-fold increase in triglyceride content of the liver. Their plasma levels of cholesterol and triglycerides are reduced by 50%. They show reduced down-regulation of mature Srebf1/2 when fed a high cholesterol diet. Belongs to the WD repeat SCAP family. Sequence=BAD32190.1; Type=Erroneous initiation; Evidence=; Golgi membrane response to hypoxia endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus lipid metabolic process immune response aging steroid metabolic process cholesterol metabolic process ER to Golgi transport vesicle membrane cholesterol binding membrane integral component of membrane regulation of fatty acid metabolic process cytoplasmic vesicle response to insulin SREBP signaling pathway sterol binding macromolecular complex regulation of fatty acid biosynthetic process intracellular membrane-bounded organelle cellular lipid metabolic process macromolecular complex binding regulation of cholesterol biosynthetic process uc009rtx.1 uc009rtx.2 uc009rtx.3 uc009rtx.4 uc009rtx.5 
ENSMUST00000098359.4 Fbxw18 ENSMUST00000098359.4 F-box and WD-40 domain protein 18 (from RefSeq NM_001033794.3) C85627 ENSMUST00000098359.1 ENSMUST00000098359.2 ENSMUST00000098359.3 Fbxw18 NM_001033794 Q3TSA9 Q3TSA9_MOUSE uc009rso.1 uc009rso.2 molecular_function cellular_component biological_process uc009rso.1 uc009rso.2 
ENSMUST00000098361.4 Adad2 ENSMUST00000098361.4 adenosine deaminase domain containing 2 (from RefSeq NM_029428.2) ADAD2_MOUSE Adad2 B2RQL4 ENSMUST00000098361.1 ENSMUST00000098361.2 ENSMUST00000098361.3 NM_029428 Q9D5P4 uc009nqa.1 uc009nqa.2 uc009nqa.3 uc009nqa.4 Required for male fertility and normal male germ cell differentiation. Nucleus Cytoplasm Note=Diffusely cytoplasmic early in pachytene spermatocytes and coalesces into several perinuclear granules by late pachynema. Testis-specific (at protein level). Male mice are sterile and show defects in germ- cell development. Belongs to the ADAD family. Sequence=BAB29697.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB29697.1; Type=Frameshift; Evidence=; RNA binding double-stranded RNA binding double-stranded RNA adenosine deaminase activity adenosine deaminase activity nucleus nucleolus cytoplasm adenosine to inosine editing RNA processing tRNA-specific adenosine deaminase activity uc009nqa.1 uc009nqa.2 uc009nqa.3 uc009nqa.4 
ENSMUST00000098363.10 Necab2 ENSMUST00000098363.10 N-terminal EF-hand calcium binding protein 2 (from RefSeq NM_054095.2) ENSMUST00000098363.1 ENSMUST00000098363.2 ENSMUST00000098363.3 ENSMUST00000098363.4 ENSMUST00000098363.5 ENSMUST00000098363.6 ENSMUST00000098363.7 ENSMUST00000098363.8 ENSMUST00000098363.9 Efcbp2 NECA2_MOUSE NM_054095 Q1LZI4 Q8C492 Q91ZP9 uc009npq.1 uc009npq.2 uc009npq.3 May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. Interacts (calcium-dependent) with ADORA2A and GRM5. Cytoplasm Cell projection, dendrite Cell projection, axon Cell membrane Note=Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (By similarity). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91ZP9-1; Sequence=Displayed; Name=2; IsoId=Q91ZP9-2; Sequence=VSP_024215; Expressed in the iris, in the ciliary margin of the retina and in the inner portion of the neural retina. Expressed in the spinal dorsal horn with especially strong expression in lamina IIi; found in excitory synaptic boutons (at protein level). Expressed in retina, retinal pigmented epithelium, Rathke's pouch, corneal epithelium, the infundibulum and olfactory placodes at 10.5 dpc (at protein level). Expressed in the inner region of the neural retina, including the ganglion cell layer at 17.5 dpc (at protein level). Expressed in the optic sulcus and in the pre-tectum at 8.5 dpc. Expressed in the optic vesicle, in the midline position in the roof of the midbrain and in the pre-tectum at 9.0-9.5 dpc. Expressed in the olfactory placodes at 10.5 dpc. Expressed in retinal-pigmented epithelium and in the neural retina, with strong expression in the ciliary margin at 12.5-13.5 dpc. Up-regulated by PAX6. Sequence=BAC38589.1; Type=Erroneous initiation; Evidence=; calcium ion binding cytoplasm plasma membrane membrane axon dendrite A2A adenosine receptor binding type 5 metabotropic glutamate receptor binding identical protein binding regulation of amyloid precursor protein biosynthetic process cell projection metal ion binding positive regulation of adenosine receptor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of glutamate receptor signaling pathway negative regulation of G-protein coupled receptor internalization positive regulation of protein localization to membrane uc009npq.1 uc009npq.2 uc009npq.3 
ENSMUST00000098367.5 Mlycd ENSMUST00000098367.5 malonyl-CoA decarboxylase, transcript variant 1 (from RefSeq NM_019966.3) DCMC_MOUSE ENSMUST00000098367.1 ENSMUST00000098367.2 ENSMUST00000098367.3 ENSMUST00000098367.4 Mlycd NM_019966 Q7TNL6 Q99J39 uc009npn.1 uc009npn.2 uc009npn.3 Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. Plays a role in controlling the extent of ischemic injury by promoting glucose oxidation. Reaction=H(+) + malonyl-CoA = acetyl-CoA + CO2; Xref=Rhea:RHEA:18781, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57288, ChEBI:CHEBI:57384; EC=4.1.1.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18782; Evidence=; Malonyl-CoA decarboxylase activity does not require any cofactors or divalent metal ions. Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from malonyl-CoA: step 1/1. Homotetramer. Dimer of dimers. The two subunits within a dimer display conformational differences suggesting that at any given moment, only one of the two subunits is competent for malonyl-CoA binding and catalytic activity. Under oxidizing conditions, can form disulfide- linked homotetramers (in vitro). Associates with the peroxisomal targeting signal receptor PEX5 (By similarity). Cytoplasm Mitochondrion matrix Peroxisome Peroxisome matrix Note=Enzymatically active in all three subcellular compartments. Event=Alternative initiation; Named isoforms=2; Comment=A single transcription start site has been demonstrated in Rat.; Name=Mitochondrial; IsoId=Q99J39-1; Sequence=Displayed; Name=Cytoplasmic+peroxisomal; IsoId=Q99J39-2; Sequence=VSP_018817; Interchain disulfide bonds may form in peroxisomes (Potential). Interchain disulfide bonds are not expected to form in the reducing environment of the cytoplasm and mitochondria. Acetylation at Lys-471 activates malonyl-CoA decarboxylase activity. Deacetylation at Lys-471 by SIRT4 represses activity, leading to promote lipogenesis. Mice show an increased expression of genes regulating fatty acid utilization and likely contributes to the absence of changes in energy metabolism in the aerobic heart. Display a preference for glucose utilization after ischemia and improve functional recovery of the heart. [Isoform Cytoplasmic+peroxisomal]: May be produced by alternative initiation at Met-39 of isoform mitochondrial. Alternatively, represents a proteolytic processed form of the mitochondrial form. response to ischemia protein binding cytoplasm mitochondrion mitochondrial matrix peroxisome peroxisomal matrix cytosol acetyl-CoA biosynthetic process lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process regulation of glucose metabolic process lyase activity carboxy-lyase activity fatty acid oxidation regulation of fatty acid beta-oxidation identical protein binding regulation of fatty acid oxidation positive regulation of fatty acid oxidation malonyl-CoA decarboxylase activity malonyl-CoA catabolic process uc009npn.1 uc009npn.2 uc009npn.3 
ENSMUST00000098382.10 Adamts17 ENSMUST00000098382.10 ADAM metallopeptidase with thrombospondin type 1 motif 17 (from RefSeq NM_001033877.4) Adamts17 E9Q4D1 E9Q4D1_MOUSE ENSMUST00000098382.1 ENSMUST00000098382.2 ENSMUST00000098382.3 ENSMUST00000098382.4 ENSMUST00000098382.5 ENSMUST00000098382.6 ENSMUST00000098382.7 ENSMUST00000098382.8 ENSMUST00000098382.9 NM_001033877 uc009hhx.1 uc009hhx.2 uc009hhx.3 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function nucleic acid binding metalloendopeptidase activity proteolysis biological_process peptidase activity metallopeptidase activity uc009hhx.1 uc009hhx.2 uc009hhx.3 
ENSMUST00000098391.11 Pcsk6 ENSMUST00000098391.11 proprotein convertase subtilisin/kexin type 6, transcript variant 2 (from RefSeq NM_001291184.1) E9Q4D0 E9Q4D0_MOUSE ENSMUST00000098391.1 ENSMUST00000098391.10 ENSMUST00000098391.2 ENSMUST00000098391.3 ENSMUST00000098391.4 ENSMUST00000098391.5 ENSMUST00000098391.6 ENSMUST00000098391.7 ENSMUST00000098391.8 ENSMUST00000098391.9 NM_001291184 Pcsk6 uc009hgw.1 uc009hgw.2 uc009hgw.3 uc009hgw.4 Belongs to the peptidase S8 family. endopeptidase activity serine-type endopeptidase activity extracellular space proteolysis zygotic determination of anterior/posterior axis, embryo determination of left/right symmetry heparin binding peptidase activity serine-type peptidase activity glycoprotein metabolic process cell surface membrane protein processing peptide hormone processing hydrolase activity nerve growth factor production secretion by cell nerve growth factor binding uc009hgw.1 uc009hgw.2 uc009hgw.3 uc009hgw.4 
ENSMUST00000098402.5 Snrpn ENSMUST00000098402.5 small nuclear ribonucleoprotein N, transcript variant 6 (from RefSeq NM_001349692.1) ENSMUST00000098402.1 ENSMUST00000098402.2 ENSMUST00000098402.3 ENSMUST00000098402.4 NM_001349692 Q3UN87 Q3UN87_MOUSE Snrpn uc009hes.1 uc009hes.2 uc009hes.3 uc009hes.4 This locus represents a paternally-expressed imprinted gene that encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing. Genomic and genetic changes in this region result in growth defects and lethality; the corresponding region in human is the critical region for Prader-Willi Syndrome. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants may be bicistronic and also encode the SNRPN upstream reading frame protein (Snurf) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (Snhg14) may originate from the promoters at this locus and incorporate exons shared with this gene. [provided by RefSeq, Mar 2017]. May be involved in tissue-specific alternative RNA processing events. Interacts with TDRD3. Nucleus Belongs to the snRNP SmB/SmN family. RNA binding nucleus nucleoplasm U1 snRNP U2 snRNP response to hormone uc009hes.1 uc009hes.2 uc009hes.3 uc009hes.4 
ENSMUST00000098414.5 Svip ENSMUST00000098414.5 small VCP/p97-interacting protein, transcript variant 1 (from RefSeq NM_001160345.1) ENSMUST00000098414.1 ENSMUST00000098414.2 ENSMUST00000098414.3 ENSMUST00000098414.4 NM_001160345 Q3UZP4 SVIP_MOUSE uc009hcn.1 uc009hcn.2 uc009hcn.3 uc009hcn.4 Interacts with VCP. Smooth endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane ; Peripheral membrane protein Membrane ; Lipid-anchor Belongs to the SVIP family. Golgi membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane positive regulation of autophagy membrane smooth endoplasmic reticulum membrane anchored component of membrane negative regulation of protein complex assembly protein self-association ATPase binding positive regulation of protein lipidation negative regulation of ER-associated ubiquitin-dependent protein catabolic process negative regulation of retrograde protein transport, ER to cytosol negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly uc009hcn.1 uc009hcn.2 uc009hcn.3 uc009hcn.4 
ENSMUST00000098433.5 Mrgprx2 ENSMUST00000098433.5 MAS-related GPR, member X2 (from RefSeq NM_001034868.3) E9PV62 ENSMUST00000098433.1 ENSMUST00000098433.2 ENSMUST00000098433.3 ENSMUST00000098433.4 MRGX2_MOUSE Mrgprb10 NM_001034868 Q3UG50 W8W3J9 uc009har.1 uc009har.2 uc009har.3 uc009har.4 Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). Cell membrane; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Mas subfamily. In spite of its official gene name, this protein may not be the functional ortholog of human MRGPRX2. Sequence=CDG86230.1; Type=Erroneous gene model prediction; Evidence=; G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane mast cell granule neuropeptide binding mast cell degranulation mast cell activation mast cell secretagogue receptor activity uc009har.1 uc009har.2 uc009har.3 uc009har.4 
ENSMUST00000098438.4 Mrgpra1 ENSMUST00000098438.4 MAS-related GPR, member A1 (from RefSeq NM_153095.2) ENSMUST00000098438.1 ENSMUST00000098438.2 ENSMUST00000098438.3 G3UW97 G3UW97_MOUSE Mrgpra1 NM_153095 uc009haf.1 uc009haf.2 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009haf.1 uc009haf.2 
ENSMUST00000098441.10 Col6a6 ENSMUST00000098441.10 collagen, type VI, alpha 6, transcript variant 1 (from RefSeq NM_001102607.1) A6H587 A6H588 A6H589 A6H590 CO6A6_MOUSE ENSMUST00000098441.1 ENSMUST00000098441.2 ENSMUST00000098441.3 ENSMUST00000098441.4 ENSMUST00000098441.5 ENSMUST00000098441.6 ENSMUST00000098441.7 ENSMUST00000098441.8 ENSMUST00000098441.9 NM_001102607 Q8C6K9 uc009ris.1 uc009ris.2 uc009ris.3 Collagen VI acts as a cell-binding protein. Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha- 6(VI). Secreted, extracellular space, extracellular matrix Note=Deposed in the extracellular matrix of skeletal muscle. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C6K9-1; Sequence=Displayed; Name=2; IsoId=Q8C6K9-2; Sequence=VSP_033916, VSP_033917; In newborn, it is expressed in lung, heart, kidney, muscle, brain, intestine, skin, femur and sternum. In adult, it is expressed in lung, heart, muscle, ovary, brain, liver and sternum. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Belongs to the type VI collagen family. extracellular region collagen trimer cell adhesion extracellular matrix structural constituent conferring tensile strength extracellular matrix uc009ris.1 uc009ris.2 uc009ris.3 
ENSMUST00000098458.4 Il20rb ENSMUST00000098458.4 interleukin 20 receptor beta (from RefSeq NM_001033543.3) E9Q9A6 E9Q9A6_MOUSE ENSMUST00000098458.1 ENSMUST00000098458.2 ENSMUST00000098458.3 Il20rb NM_001033543 uc012gzd.1 uc012gzd.2 uc012gzd.3 negative regulation of type IV hypersensitivity inflammatory response to antigenic stimulus immune response-inhibiting signal transduction cytokine receptor activity plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway negative regulation of interferon-gamma production negative regulation of interleukin-2 production positive regulation of interleukin-10 production positive regulation of interleukin-4 production interleukin-20 binding negative regulation of T cell proliferation homeostasis of number of cells within a tissue regulation of T cell activation uc012gzd.1 uc012gzd.2 uc012gzd.3 
ENSMUST00000098460.2 Prr23a4 ENSMUST00000098460.2 proline rich 23A, member 4 (from RefSeq NM_001033983.3) 7420426K07Rik ENSMUST00000098460.1 NM_001033983 Prr23a4 Q3UX66 Q3UX66_MOUSE uc009rdp.1 uc009rdp.2 Belongs to the PRR23 family. molecular_function cellular_component biological_process uc009rdp.1 uc009rdp.2 
ENSMUST00000098461.10 Cd37 ENSMUST00000098461.10 CD37 antigen, transcript variant 3 (from RefSeq NM_007645.4) CD37_MOUSE ENSMUST00000098461.1 ENSMUST00000098461.2 ENSMUST00000098461.3 ENSMUST00000098461.4 ENSMUST00000098461.5 ENSMUST00000098461.6 ENSMUST00000098461.7 ENSMUST00000098461.8 ENSMUST00000098461.9 NM_007645 Q61470 uc009guh.1 uc009guh.2 uc009guh.3 Interacts with SCIMP. Membrane; Multi-pass membrane protein. Belongs to the tetraspanin (TM4SF) family. immunological synapse positive regulation of immunoglobulin production regulation of humoral immune response integral component of plasma membrane negative regulation of cell proliferation membrane integral component of membrane negative regulation of myeloid dendritic cell activation defense response to protozoan regulation of defense response to virus uc009guh.1 uc009guh.2 uc009guh.3 
ENSMUST00000098477.8 Plscr1l1 ENSMUST00000098477.8 phospholipid scramblase 1 like 1 (from RefSeq NM_001033184.3) 1700057G04Rik ENSMUST00000098477.1 ENSMUST00000098477.2 ENSMUST00000098477.3 ENSMUST00000098477.4 ENSMUST00000098477.5 ENSMUST00000098477.6 ENSMUST00000098477.7 NM_001033184 Plscr1l1 Q3V0U0 Q3V0U0_MOUSE uc009raq.1 uc009raq.2 May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= Belongs to the phospholipid scramblase family. plasma membrane phospholipid scrambling phospholipid scramblase activity uc009raq.1 uc009raq.2 
ENSMUST00000098485.4 Bcl2a1a ENSMUST00000098485.4 B cell leukemia/lymphoma 2 related protein A1a (from RefSeq NM_009742.3) A1 B2LA1_MOUSE Bcl2a1 Bfl1 ENSMUST00000098485.1 ENSMUST00000098485.2 ENSMUST00000098485.3 NM_009742 Q07440 uc009qzh.1 uc009qzh.2 uc009qzh.3 Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (PubMed:11888890). Interacts directly with BCL2L11/BIM and PMAIP1 (By similarity). Interacts directly with BAK1, BID, BMF and BBC3. Interacts with BOP (By similarity). Interacts with isoform 3, isoform 4 and isoform 5 of ING4. Interacts with UBQLN4 (By similarity). Q07440; O08734: Bak1; NbExp=2; IntAct=EBI-707754, EBI-822441; Q07440; Q99ML1: Bbc3; NbExp=2; IntAct=EBI-707754, EBI-727801; Q07440; P70444: Bid; NbExp=2; IntAct=EBI-707754, EBI-783400; Q07440; Q91ZE9: Bmf; NbExp=2; IntAct=EBI-707754, EBI-708032; Q07440; O43521: BCL2L11; Xeno; NbExp=2; IntAct=EBI-707754, EBI-526406; Q07440; P55957: BID; Xeno; NbExp=3; IntAct=EBI-707754, EBI-519672; Cytoplasm Expressed in hemopoietic tissues, including bone marrow, spleen and thymus. By granulocyte-macrophage colony-stimulating factor and LPS in macrophages. Belongs to the Bcl-2 family. B cell homeostasis negative regulation of B cell apoptotic process protein binding cytoplasm mitochondrial outer membrane apoptotic process intrinsic apoptotic signaling pathway in response to DNA damage protein homodimerization activity regulation of apoptotic process negative regulation of apoptotic process protein heterodimerization activity BH domain binding extrinsic apoptotic signaling pathway in absence of ligand uc009qzh.1 uc009qzh.2 uc009qzh.3 
ENSMUST00000098486.4 Bcl2a1d ENSMUST00000098486.4 B cell leukemia/lymphoma 2 related protein A1d (from RefSeq NM_007536.2) A1d Bcl2a1d ENSMUST00000098486.1 ENSMUST00000098486.2 ENSMUST00000098486.3 NM_007536 O55179 O55179_MOUSE uc009qzc.1 uc009qzc.2 uc009qzc.3 Belongs to the Bcl-2 family. mitochondrial outer membrane intrinsic apoptotic signaling pathway in response to DNA damage T cell differentiation protein homodimerization activity regulation of apoptotic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein heterodimerization activity T cell receptor signaling pathway BH domain binding extrinsic apoptotic signaling pathway in absence of ligand uc009qzc.1 uc009qzc.2 uc009qzc.3 
ENSMUST00000098503.9 Zfp976 ENSMUST00000098503.9 zinc finger protein 976 (from RefSeq NM_001242388.1) E9Q981 E9Q981_MOUSE ENSMUST00000098503.1 ENSMUST00000098503.2 ENSMUST00000098503.3 ENSMUST00000098503.4 ENSMUST00000098503.5 ENSMUST00000098503.6 ENSMUST00000098503.7 ENSMUST00000098503.8 NM_001242388 Zfp976 uc029wfc.1 uc029wfc.2 uc029wfc.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated cellular response to heat metal ion binding uc029wfc.1 uc029wfc.2 uc029wfc.3 
ENSMUST00000098508.9 Zfp788 ENSMUST00000098508.9 zinc finger protein 788, transcript variant 2 (from RefSeq NM_001360675.1) E9Q980 E9Q980_MOUSE ENSMUST00000098508.1 ENSMUST00000098508.2 ENSMUST00000098508.3 ENSMUST00000098508.4 ENSMUST00000098508.5 ENSMUST00000098508.6 ENSMUST00000098508.7 ENSMUST00000098508.8 NM_001360675 Zfp788 uc009glu.1 uc009glu.2 uc009glu.3 uc009glu.4 nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc009glu.1 uc009glu.2 uc009glu.3 uc009glu.4 
ENSMUST00000098509.5 AW146154 ENSMUST00000098509.5 expressed sequence AW146154 (from RefSeq NM_001033530.3) AW146154 ENSMUST00000098509.1 ENSMUST00000098509.2 ENSMUST00000098509.3 ENSMUST00000098509.4 NM_001033530 Q3TPQ7 Q3TPQ7_MOUSE uc009glq.1 uc009glq.2 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009glq.1 uc009glq.2 
ENSMUST00000098513.6 Plekhf1 ENSMUST00000098513.6 pleckstrin homology domain containing, family F (with FYVE domain) member 1 (from RefSeq NM_024413.2) ENSMUST00000098513.1 ENSMUST00000098513.2 ENSMUST00000098513.3 ENSMUST00000098513.4 ENSMUST00000098513.5 Lapf NM_024413 PKHF1_MOUSE Q3TB82 Q99M16 uc009gku.1 uc009gku.2 uc009gku.3 uc009gku.4 May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity). Nucleus Cytoplasm, perinuclear region Lysosome Note=Translocates to lysosome during apoptosis. Widely expressed. PH and FYVE-type zinc finger domains are required for lysosomal location. nucleus cytoplasm mitochondrion lysosome endosome apoptotic process endosome organization phosphatidylinositol-5-phosphate binding positive regulation of autophagy vesicle organization phosphatidylinositol-3-phosphate binding phosphatidylinositol binding metal ion binding regulation of mitochondrial membrane permeability perinuclear region of cytoplasm phosphatidylinositol-4-phosphate binding protein localization to plasma membrane positive regulation of intrinsic apoptotic signaling pathway uc009gku.1 uc009gku.2 uc009gku.3 uc009gku.4 
ENSMUST00000098524.5 Mcoln2 ENSMUST00000098524.5 mucolipin 2, transcript variant 2 (from RefSeq NM_001005846.2) ENSMUST00000098524.1 ENSMUST00000098524.2 ENSMUST00000098524.3 ENSMUST00000098524.4 MCLN2_MOUSE NM_001005846 Q3UCG4 Q8K2T6 Q8K595 Q9CQD3 uc008rqz.1 uc008rqz.2 Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19763610). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (By similarity). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (PubMed:17050035). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (PubMed:26432893). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Channel activity is reduced by low extracellular/lumenal pH level. Forms homooligomeric complexes; probably tetrameric. Can heterooligomerize with MCOLN1; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific. Interacts with TMEM176A. Cell membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Note=Localizes to recycling endosomes in activated macrophages and microglia. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=TRPML2lv; IsoId=Q8K595-1; Sequence=Displayed; Name=2; Synonyms=TRPML2sv; IsoId=Q8K595-2; Sequence=VSP_010822; Isoform 1 is widely expressed at very low levels. Isoform 2 is expressed at high levels in lymphoid tissues (thymus and spleen) and kidney, and at moderate levels in heart, lung, liver and stomach. Expressed in activated macrophages and microglia (at protein level). Up-regulated in microglia cells and macrophages by bacterial lipopolysaccharide (LPS). Up-regulated by infection with M.smegmatis. The most N-terminal extracellular/lumenal domain (referred to as I-II linker or polycystin-mucolipin domain) contributes to a structure with a four-fold rotational symmetry in a tetrameric assembly; the structure contains a central highly electronegative pore with a 14 A diameter. The pore is critical for Ca(2+) and pH regulation. The protruding structure formed by the I-II linkers may contain all the interaction sites with lipids and proteins in the endolysosomal lumen. No visible phenotype. The secretion of specific cytokines (CCL3, CCL5 and CXCL2) by macrophages exposed to bacterial lipopolysaccharide (LPS) is decreased. Mutant mice display decreased migration of macrophages into the intraperitoneal space after injection with LPS, or after infection with E.coli O78:H11 (strain H10407). Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN2 sub-subfamily. adaptive immune response immune system process cation channel activity calcium channel activity lysosome endosome ion transport calcium ion transport protein transport membrane integral component of membrane positive regulation of chemokine production chemokine (C-C motif) ligand 2 secretion identical protein binding innate immune response release of sequestered calcium ion into cytosol recycling endosome recycling endosome membrane calcium ion transmembrane transport positive regulation of monocyte chemotactic protein-1 production positive regulation of macrophage inflammatory protein 1 alpha production positive regulation of chemokine (C-C motif) ligand 5 production NAADP-sensitive calcium-release channel activity macrophage migration neutrophil migration positive regulation of chemokine (C-X-C motif) ligand 2 production lysosomal membrane plasma membrane uc008rqz.1 uc008rqz.2 
ENSMUST00000098534.9 Znhit6 ENSMUST00000098534.9 zinc finger, HIT type 6, transcript variant 1 (from RefSeq NM_001081094.1) B2RW16 BCD1_MOUSE Bcd1 ENSMUST00000098534.1 ENSMUST00000098534.2 ENSMUST00000098534.3 ENSMUST00000098534.4 ENSMUST00000098534.5 ENSMUST00000098534.6 ENSMUST00000098534.7 ENSMUST00000098534.8 NM_001081094 Q3TG81 Q3UFB2 uc008rqo.1 uc008rqo.2 uc008rqo.3 Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9 (By similarity). Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UFB2-1; Sequence=Displayed; Name=2; IsoId=Q3UFB2-2; Sequence=VSP_023573; Belongs to the BCD1 family. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) box C/D snoRNP assembly TFIID-class transcription factor binding nucleus enzyme binding ribosome biogenesis identical protein binding metal ion binding snoRNA localization ATPase binding protein oligomerization pre-snoRNP complex uc008rqo.1 uc008rqo.2 uc008rqo.3 
ENSMUST00000098537.4 Gsta1 ENSMUST00000098537.4 glutathione S-transferase, alpha 1 (Ya) (from RefSeq NM_008181.3) A2RTN4 ENSMUST00000098537.1 ENSMUST00000098537.2 ENSMUST00000098537.3 GSTA1_MOUSE Gsta Gstya NM_008181 P13745 uc009qtz.1 uc009qtz.2 uc009qtz.3 Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (PubMed:9606968). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene- 3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)- octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (By similarity). Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16438; Evidence=; Reaction=glutathione + prostaglandin A2 = prostaglandin A2-S-(R)- glutathione; Xref=Rhea:RHEA:50796, ChEBI:CHEBI:57925, ChEBI:CHEBI:133370, ChEBI:CHEBI:133768; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50797; Evidence=; Reaction=glutathione + prostaglandin J2 = prostaglandin J2-S-(R)- glutathione; Xref=Rhea:RHEA:50804, ChEBI:CHEBI:57925, ChEBI:CHEBI:133396, ChEBI:CHEBI:133771; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50805; Evidence=; Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48888, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90850; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48889; Evidence=; Reaction=androst-5-ene-3,17-dione = androst-4-ene-3,17-dione; Xref=Rhea:RHEA:43936, ChEBI:CHEBI:16422, ChEBI:CHEBI:83865; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43937; Evidence=; Kinetic parameters: KM=35 uM for 7,8-Dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene ; Vmax=5200 nmol/min/mg enzyme for 7,8-Dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene ; Homodimer. Expressed in the liver, skin and kidney. Induced in the liver by beta-naphthoflavone (BNF) and 2(3)- t-butyl-4-hydroxyanisole (BHA). Belongs to the GST superfamily. Alpha family. glutathione transferase activity peroxidase activity steroid delta-isomerase activity cytosol prostaglandin metabolic process glutathione metabolic process xenobiotic metabolic process response to bacterium oxidoreductase activity transferase activity isomerase activity response to stilbenoid glutathione binding oxidation-reduction process cellular oxidant detoxification glutathione derivative biosynthetic process uc009qtz.1 uc009qtz.2 uc009qtz.3 
ENSMUST00000098538.9 Odf2l ENSMUST00000098538.9 outer dense fiber of sperm tails 2-like, transcript variant 1 (from RefSeq NM_001162538.1) Bcap D3Ertd250e ENSMUST00000098538.1 ENSMUST00000098538.2 ENSMUST00000098538.3 ENSMUST00000098538.4 ENSMUST00000098538.5 ENSMUST00000098538.6 ENSMUST00000098538.7 ENSMUST00000098538.8 NM_001162538 ODF2L_MOUSE Q8CD32 Q8VDY5 Q9D478 Q9D647 uc008rqk.1 uc008rqk.2 uc008rqk.3 uc008rqk.4 Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cytoplasm, cytoskeleton, cilium basal body Note=Localizes to centrioles in proliferative cells and basal bodies in ciliated cells. Disappears during ciliogenesis but reappears, albeit at a lower levels once ciliogenesis has completed. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D478-1; Sequence=Displayed; Name=2; IsoId=Q9D478-2; Sequence=VSP_029062; Name=3; IsoId=Q9D478-3; Sequence=VSP_029061, VSP_029062; Belongs to the ODF2 family. molecular_function cytoplasm centrosome centriole microtubule organizing center cytoskeleton cell projection organization centriolar satellite ciliary basal body cell projection negative regulation of cilium assembly uc008rqk.1 uc008rqk.2 uc008rqk.3 uc008rqk.4 
ENSMUST00000098548.8 Scn1b ENSMUST00000098548.8 sodium channel, voltage-gated, type I, beta, transcript variant 1 (from RefSeq NM_011322.4) ENSMUST00000098548.1 ENSMUST00000098548.2 ENSMUST00000098548.3 ENSMUST00000098548.4 ENSMUST00000098548.5 ENSMUST00000098548.6 ENSMUST00000098548.7 NM_011322 P97952 SCN1B_MOUSE uc009gie.1 uc009gie.2 uc009gie.3 Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. Component of a voltage-sensitive sodium channel complex that consists of a pore-forming alpha subunit and one or more regulatory beta subunits. Interacts with SCN4A. Interacts with NFASC. Interacts with SCN10A (By similarity). Interacts with SCN1A. Interacts with SCN3A. Interacts with SCN5A. Interacts with SCN8A (By similarity). Cell membrane ; Single-pass type I membrane protein Perikaryon Cell projection Cell projection, axon Note=Detected at nodes of Ranvier on the sciatic nerve. Detected in hippocampus CA3 bipolar neurons (at protein level) (PubMed:19710327). Detected in skeletal muscle (PubMed:9013777). Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family. voltage-gated sodium channel complex regulation of sodium ion transport voltage-gated ion channel activity voltage-gated sodium channel activity sodium channel activity protein binding plasma membrane integral component of plasma membrane ion transport sodium ion transport axon guidance positive regulation of sodium ion transport positive regulation of neuron projection development intercalated disc membrane integral component of membrane sodium channel regulator activity neuronal action potential propagation sodium channel inhibitor activity corticospinal neuron axon guidance T-tubule axon node of Ranvier sodium channel complex regulation of ion transmembrane transport sodium ion transmembrane transport locomotion cell projection perikaryon ion channel binding response to pyrethroid membrane depolarization cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane depolarization cardiac conduction cardiac muscle cell action potential involved in contraction voltage-gated sodium channel activity involved in cardiac muscle cell action potential membrane depolarization during cardiac muscle cell action potential membrane depolarization during Purkinje myocyte cell action potential voltage-gated sodium channel activity involved in Purkinje myocyte action potential regulation of heart rate by cardiac conduction regulation of voltage-gated sodium channel activity regulation of sodium ion transmembrane transporter activity uc009gie.1 uc009gie.2 uc009gie.3 
ENSMUST00000098549.4 Clca4b ENSMUST00000098549.4 chloride channel accessory 4B (from RefSeq NM_001033199.3) AI747448 Clca4b Clca7 ENSMUST00000098549.1 ENSMUST00000098549.2 ENSMUST00000098549.3 NM_001033199 Q3UW98 Q3UW98_MOUSE uc008rqd.1 uc008rqd.2 Belongs to the CLCR family. intracellular calcium activated chloride channel activity integral component of plasma membrane chloride transport membrane integral component of membrane ion transmembrane transport uc008rqd.1 uc008rqd.2 
ENSMUST00000098551.7 Clca4c-ps ENSMUST00000098551.7 chloride channel accessory 4C, pseudogene (from RefSeq NR_126537.1) ENSMUST00000098551.1 ENSMUST00000098551.2 ENSMUST00000098551.3 ENSMUST00000098551.4 ENSMUST00000098551.5 ENSMUST00000098551.6 NR_126537 uc008rqc.1 uc008rqc.2 uc008rqc.3 uc008rqc.4 uc008rqc.5 uc008rqc.1 uc008rqc.2 uc008rqc.3 uc008rqc.4 uc008rqc.5 
ENSMUST00000098559.3 Krtdap ENSMUST00000098559.3 keratinocyte differentiation associated protein, transcript variant 1 (from RefSeq NM_001033131.4) B7ZNU7 ENSMUST00000098559.1 ENSMUST00000098559.2 KTDAP_MOUSE Kdap Krtdap NM_001033131 Q3V2T1 Q3V2T4 uc009ggm.1 uc009ggm.2 uc009ggm.3 May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity). Secreted Event=Alternative splicing; Named isoforms=2; Name=1 IsoId=Q3V2T4-1; Sequence=Displayed; Name=2 ; IsoId=Q3V2T4-2; Sequence=VSP_052660; Expression restricted to suprabasal keratinocytes of the epidermis. extracellular region extracellular space epidermis development cell differentiation lamellar body uc009ggm.1 uc009ggm.2 uc009ggm.3 
ENSMUST00000098571.6 G430095P16Rik ENSMUST00000098571.6 G430095P16Rik (from geneSymbol) AK165649 ENSMUST00000098571.1 ENSMUST00000098571.2 ENSMUST00000098571.3 ENSMUST00000098571.4 ENSMUST00000098571.5 uc009mng.1 uc009mng.2 uc009mng.3 uc009mng.4 uc009mng.5 uc009mng.6 uc009mng.7 uc009mng.1 uc009mng.2 uc009mng.3 uc009mng.4 uc009mng.5 uc009mng.6 uc009mng.7 
ENSMUST00000098574.9 Rap1gds1 ENSMUST00000098574.9 RAP1, GTP-GDP dissociation stimulator 1, transcript variant 8 (from RefSeq NM_001411346.1) E9Q6Q4 E9Q912 ENSMUST00000098574.1 ENSMUST00000098574.2 ENSMUST00000098574.3 ENSMUST00000098574.4 ENSMUST00000098574.5 ENSMUST00000098574.6 ENSMUST00000098574.7 ENSMUST00000098574.8 GDS1_MOUSE I6L967 NM_001411346 Q3TA69 Q3TLU4 Q3TPS9 Q3TU36 Rap1gds1 uc008rnr.1 uc008rnr.2 uc008rnr.3 uc008rnr.4 Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP. Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity. Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS. Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions. Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake. [Isoform 1]: Acts as a GEF (guanine nucleotide exchange factor) for unprenylated RHOA. Chaperones the entry and passage of small GTPases through the prenylation pathway. Recognizes the last amino acid in the GTPase C-terminal CAAX motif with a preference for 'Leu' over 'Met', indicating involvement in the geranylgeranylation pathway. May also recognize prenylated GTPases. [Isoform 3]: Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA. Acts as a GEF for RHOC. Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases. Escorts RAC1 to the nucleus. Interacts with RABL3. Interacts with RHOT1. [Isoform 1]: Interacts with unprenylated RHOA; the interaction is direct. Interacts with RAP1A. Interacts with KRAS. Interacts with RAC1. Interacts with RAP1B. Preferentially interacts with unprenylated GTPases that will become geranylgeranylated. May also interact with prenylated GTPases. [Isoform 3]: Interacts with prenylated RHOA; the interaction is direct and in a 1:1 stoichiometry. Interacts with RAP1A. Interacts with KRAS. Interacts with RAC1. Interacts with RAP1B. Preferentially interacts with prenylated GTPases. Cytoplasm, cytosol Endoplasmic reticulum Mitochondrion Nucleus Note=Nuclear import is dependent on complexing with a GTPase containing a C-terminal polybasic region. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=E9Q912-1; Sequence=Displayed; Name=2; IsoId=E9Q912-2; Sequence=VSP_061009; Name=3; IsoId=E9Q912-3; Sequence=VSP_061008; Serotonylated on Gln residues by TGM2 in response to hypoxia, leading to its inactivation. molecular_function GTPase activator activity mitochondrion endoplasmic reticulum cytosol vascular smooth muscle contraction myosin filament assembly negative regulation of endoplasmic reticulum calcium ion concentration positive regulation of GTPase activity positive regulation of mitochondrial calcium ion concentration uc008rnr.1 uc008rnr.2 uc008rnr.3 uc008rnr.4 
ENSMUST00000098578.10 Yju2b ENSMUST00000098578.10 YJU2 splicing factor homolog B, transcript variant 1 (from RefSeq NM_026350.3) Ccdc130 ENSMUST00000098578.1 ENSMUST00000098578.2 ENSMUST00000098578.3 ENSMUST00000098578.4 ENSMUST00000098578.5 ENSMUST00000098578.6 ENSMUST00000098578.7 ENSMUST00000098578.8 ENSMUST00000098578.9 NM_026350 Q8VCB4 Q9D516 YJU2B_MOUSE uc009mml.1 uc009mml.2 uc009mml.3 uc009mml.4 May be involved in mRNA splicing. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D516-1; Sequence=Displayed; Name=2; IsoId=Q9D516-2; Sequence=VSP_023900, VSP_023901; Belongs to the CWC16 family. molecular_function cellular_component biological_process response to virus uc009mml.1 uc009mml.2 uc009mml.3 uc009mml.4 
ENSMUST00000098586.5 Sdhaf1 ENSMUST00000098586.5 succinate dehydrogenase complex assembly factor 1 (from RefSeq NM_001033140.3) B2RVF8 ENSMUST00000098586.1 ENSMUST00000098586.2 ENSMUST00000098586.3 ENSMUST00000098586.4 Lyrm8 NM_001033140 Q3U276 SDHF1_MOUSE Sdhaf1 uc009ged.1 uc009ged.2 uc009ged.3 Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Interacts with SDHB within an SDHA-SDHB subcomplex. Also interacts with the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Binding of SDHAF1 to SDHB precedes and is necessary for recruitment of the iron-sulfur transfer complex by SDHAF1. Mitochondrion matrix Belongs to the complex I LYR family. SDHAF1 subfamily. molecular_function mitochondrion mitochondrial matrix mitochondrial respiratory chain complex II assembly uc009ged.1 uc009ged.2 uc009ged.3 
ENSMUST00000098592.3 Gm10643 ENSMUST00000098592.3 Gm10643 (from geneSymbol) ENSMUST00000098592.1 ENSMUST00000098592.2 Gm10643 Q3URG9 Q3URG9_MOUSE uc292bmp.1 uc292bmp.2 molecular_function cellular_component biological_process uc292bmp.1 uc292bmp.2 
ENSMUST00000098594.4 Cox7a1 ENSMUST00000098594.4 cytochrome c oxidase subunit 7A1, transcript variant 2 (from RefSeq NM_009944.3) Cox7a1 ENSMUST00000098594.1 ENSMUST00000098594.2 ENSMUST00000098594.3 NM_009944 Q792A4 Q792A4_MOUSE uc009gdp.1 uc009gdp.2 uc009gdp.3 Energy metabolism; oxidative phosphorylation. Membrane ; Single- pass membrane protein Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the cytochrome c oxidase VIIa family. cytochrome-c oxidase activity mitochondrial respiratory chain electron carrier activity membrane integral component of membrane electron transport chain hydrogen ion transmembrane transport uc009gdp.1 uc009gdp.2 uc009gdp.3 
ENSMUST00000098595.3 Gm10644 ENSMUST00000098595.3 predicted gene 10644 (from RefSeq NR_169070.1) ENSMUST00000098595.1 ENSMUST00000098595.2 NR_169070 uc009mlj.1 uc009mlj.2 uc009mlj.3 uc009mlj.1 uc009mlj.2 uc009mlj.3 
ENSMUST00000098596.11 Zfp382 ENSMUST00000098596.11 zinc finger protein 382, transcript variant 3 (from RefSeq NM_001362159.1) B2RXC5 ENSMUST00000098596.1 ENSMUST00000098596.10 ENSMUST00000098596.2 ENSMUST00000098596.3 ENSMUST00000098596.4 ENSMUST00000098596.5 ENSMUST00000098596.6 ENSMUST00000098596.7 ENSMUST00000098596.8 ENSMUST00000098596.9 NM_001362159 Q3UYY9 ZN382_MOUSE Znf382 uc009gdf.1 uc009gdf.2 uc009gdf.3 Functions as a sequence-specific transcriptional repressor. Interacts with TRIM28; enhances the transcriptional repressor activity. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. It is uncertain whether Met-1 or Met-37 is the initiator. negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding uc009gdf.1 uc009gdf.2 uc009gdf.3 
ENSMUST00000098602.2 ENSMUSG00000121856 ENSMUST00000098602.2 ENSMUSG00000121856 (from geneSymbol) AK133138 ENSMUST00000098602.1 uc291nra.1 uc291nra.2 uc291nra.1 uc291nra.2 
ENSMUST00000098603.8 Tet2 ENSMUST00000098603.8 tet methylcytosine dioxygenase 2, transcript variant 1 (from RefSeq NM_001040400.2) ENSMUST00000098603.1 ENSMUST00000098603.2 ENSMUST00000098603.3 ENSMUST00000098603.4 ENSMUST00000098603.5 ENSMUST00000098603.6 ENSMUST00000098603.7 Kiaa1546 NM_001040400 Q3U5R5 Q3U633 Q3UAI0 Q4JK59 Q6ZPN2 Q8K2K3 TET2_MOUSE uc008rkq.1 uc008rkq.2 uc008rkq.3 uc008rkq.4 Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Reaction=2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate; Xref=Rhea:RHEA:52636, Rhea:RHEA-COMP:11370, Rhea:RHEA-COMP:13315, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:85454, ChEBI:CHEBI:136731; EC=1.14.11.80; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52637; Evidence=; Reaction=2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 = a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate; Xref=Rhea:RHEA:53828, Rhea:RHEA-COMP:13315, Rhea:RHEA-COMP:13656, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:136731, ChEBI:CHEBI:137731; EC=1.14.11.80; Evidence=; Reaction=2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate; Xref=Rhea:RHEA:53832, Rhea:RHEA-COMP:13656, Rhea:RHEA-COMP:13657, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:137731, ChEBI:CHEBI:137732; EC=1.14.11.80; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 zinc ions per subunit. The zinc ions have a structural role. ; Interacts with HCFC1 (By similarity). Interacts with OGT (PubMed:23352454). Interacts with PROSER1; this interaction mediates TET2 O-GlcNAcylation and stability by promoting the interaction between OGT and TET2 (By similarity). Directly interacts (via C-terminus) with the DCAF1 component of the CRL4(VprBP) E3 ubiquitin-protein ligase complex (By similarity). Q4JK59; Q8CGY8: Ogt; NbExp=2; IntAct=EBI-4291768, EBI-928496; Q4JK59; P22561: Wt1; NbExp=2; IntAct=EBI-4291768, EBI-8327829; Nucleus Chromosome Note=Localization to chromatin depends upon monoubiquitination at Lys-1212. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q4JK59-1; Sequence=Displayed; Name=2; IsoId=Q4JK59-2; Sequence=VSP_032287; Name=3; IsoId=Q4JK59-3; Sequence=VSP_032286; Expressed in the brain, kidney, heart, lung, muscle and stomach (PubMed:16722336, PubMed:24357321). Expressed in germinal vesicle (GV) stage and MII-stage oocytes and in early embryos (PubMed:24357321). Present in embryonic stem cells (ES cells) (PubMed:20639862). Expressed at high levels in early embryos from 1- cell stage until at least blastula (PubMed:24357321). Expressed during embryonic development in both somatic and primordial germ cells from 9.5 dpc, with a peak in primordial germ cells at 16.5 dpc (PubMed:23151479). May be glycosylated. It is unclear whether interaction with OGT leads to GlcNAcylation. According to a report, it is GlcNAcylated by OGT (PubMed:23352454). In contrast, another group reports no GlcNAcylation by OGT in human ortholog. Monoubiquitinated at Lys-1212 by the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex called CRL4(VprBP) or CUL4A-RBX1-DDB1- DCAF1/VPRBP complex; this modification promotes binding to DNA. Mice are viable and fertile but develop chronic myelomonocytic leukemia probably caused by dysregulation of hematopoietic stem cells. Mice lacking both Tet1 and Tet2 are fertile, with females having smaller ovaries and reduced fertility. They display decreased 5-hydroxymethylcytosine (5hmC) and abnormal methylation at various imprinted loci. Embryonic stem cells lacking both Tet1 and Tet2 remain pluripotent but lack 5hmC, leading to developmental defects in chimeric embryos. Belongs to the TET family. Subsequent steps in cytosine demethylation are subject to discussion. According to a first model cytosine demethylation occurs through deamination of 5hmC into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. According to another model, cytosine demethylation is rather mediated via conversion of 5hmC into 5fC and 5caC, followed by excision by TDG (PubMed:21817016). Sequence=AAY90126.1; Type=Frameshift; Evidence=; Sequence=BAC98199.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE30334.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE30334.1; Type=Frameshift; Evidence=; Sequence=BAE31106.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE31842.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE31892.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE32012.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; kidney development myeloid progenitor cell differentiation DNA binding iron ion binding nucleus nucleoplasm 5-methylcytosine catabolic process chromatin organization protein O-linked glycosylation cell cycle ferrous iron binding zinc ion binding post-embryonic development oxidoreductase activity 5-methylcytosine metabolic process cytosine metabolic process hemoglobin metabolic process hemopoiesis myeloid cell differentiation oxidative DNA demethylation positive regulation of transcription from RNA polymerase II promoter metal ion binding spleen development homeostasis of number of cells dioxygenase activity oxidation-reduction process hematopoietic stem cell homeostasis methylcytosine dioxygenase activity oxidative demethylation liver morphogenesis DNA demethylation histone H3-K4 trimethylation uc008rkq.1 uc008rkq.2 uc008rkq.3 uc008rkq.4 
ENSMUST00000098604.12 Spint2 ENSMUST00000098604.12 serine protease inhibitor, Kunitz type 2, transcript variant 1 (from RefSeq NM_011464.2) ENSMUST00000098604.1 ENSMUST00000098604.10 ENSMUST00000098604.11 ENSMUST00000098604.2 ENSMUST00000098604.3 ENSMUST00000098604.4 ENSMUST00000098604.5 ENSMUST00000098604.6 ENSMUST00000098604.7 ENSMUST00000098604.8 ENSMUST00000098604.9 Hai2 NM_011464 Q5D0F2 Q9WU03 Q9WU04 Q9WU05 SPIT2_MOUSE uc009gbk.1 uc009gbk.2 uc009gbk.3 Inhibitor of HGFAC (By similarity). Also inhibits plasmin, and plasma and tissue kallikrein (By similarity). Inhibits serine protease activity of TMPRSS13 (By similarity). Inhibits serine protease activity of ST14/matriptase in vitro (By similarity). Interacts with TMPRSS13; the interaction promotes the phosphorylation and cell membrane localization of TMPRSS13. Cell membrane ; Single-pass type I membrane protein Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9WU03-1; Sequence=Displayed; Name=2; IsoId=Q9WU03-2; Sequence=VSP_003034; Name=3; IsoId=Q9WU03-3; Sequence=VSP_003034, VSP_003035, VSP_003036; Isoform 2 is more predominantly expressed than isoform 1. This inhibitor contains two inhibitory domains. neural tube closure serine-type endopeptidase inhibitor activity cytoplasm plasma membrane establishment or maintenance of cell polarity negative regulation of peptidase activity negative regulation of endopeptidase activity membrane integral component of membrane negative regulation of cell-cell adhesion peptidase inhibitor activity epithelial cell morphogenesis involved in placental branching basement membrane organization cellular response to BMP stimulus negative regulation of cell motility negative regulation of neural precursor cell proliferation uc009gbk.1 uc009gbk.2 uc009gbk.3 
ENSMUST00000098605.3 Gm10645 ENSMUST00000098605.3 Gm10645 (from geneSymbol) AK143076 ENSMUST00000098605.1 ENSMUST00000098605.2 uc292bjl.1 uc292bjl.2 uc292bjl.1 uc292bjl.2 
ENSMUST00000098612.3 Gm10647 ENSMUST00000098612.3 Gm10647 (from geneSymbol) AK149255 ENSMUST00000098612.1 ENSMUST00000098612.2 uc292iik.1 uc292iik.2 uc292iik.1 uc292iik.2 
ENSMUST00000098639.9 Zfp974 ENSMUST00000098639.9 zinc finger protein 974, transcript variant 2 (from RefSeq NM_028538.3) 1700049G17Rik ENSMUST00000098639.1 ENSMUST00000098639.2 ENSMUST00000098639.3 ENSMUST00000098639.4 ENSMUST00000098639.5 ENSMUST00000098639.6 ENSMUST00000098639.7 ENSMUST00000098639.8 NM_028538 Q3UVF6 Q3UVF6_MOUSE Zfp974 uc009fxi.1 uc009fxi.2 nucleic acid binding uc009fxi.1 uc009fxi.2 
ENSMUST00000098651.6 Pias1 ENSMUST00000098651.6 protein inhibitor of activated STAT 1 (from RefSeq NM_019663.3) ENSMUST00000098651.1 ENSMUST00000098651.2 ENSMUST00000098651.3 ENSMUST00000098651.4 ENSMUST00000098651.5 NM_019663 Pias1 Q2M4G9 Q2M4G9_MOUSE uc009qas.1 uc009qas.2 uc009qas.3 Protein modification; protein sumoylation. Belongs to the PIAS family. G1/S transition of mitotic cell cycle nucleus spermatogenesis protein C-terminus binding zinc ion binding visual learning protein sumoylation enzyme binding protein domain specific binding positive regulation of protein sumoylation negative regulation of apoptotic process positive regulation of transcription, DNA-templated positive regulation of smooth muscle cell differentiation SUMO ligase activity protein-DNA complex assembly uc009qas.1 uc009qas.2 uc009qas.3 
ENSMUST00000098653.3 Gm10654 ENSMUST00000098653.3 Gm10654 (from geneSymbol) AK140235 ENSMUST00000098653.1 ENSMUST00000098653.2 uc292atv.1 uc292atv.2 uc292atv.1 uc292atv.2 
ENSMUST00000098657.5 Cyp2a4 ENSMUST00000098657.5 cytochrome P450, family 2, subfamily a, polypeptide 4 (from RefSeq NM_009997.2) CP2A4_MOUSE Cyp2a-4 ENSMUST00000098657.1 ENSMUST00000098657.2 ENSMUST00000098657.3 ENSMUST00000098657.4 NM_009997 P15392 Q91XG2 uc009fui.1 uc009fui.2 uc009fui.3 Highly active in the 15-alpha-hydroxylation of testosterone. Also active in the 15-alpha-hydroxylation of progesterone and androstenedione. Little or no activity on corticosterone, pregnenolone, dehydroepiandrosterone, estradiol or estriol. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Kidney and lung. Expressed in liver, with a strong circadian rhythmicity. Circadian expression is regulated by DBP. There are only 11 differences between the sequence of testosterone 15-alpha-hydroxylase and that of coumarin 7-hydroxylase. By site-directed mutagenesis it has been shown that modification of position 209 is sufficient to convert the specificity of the two forms of the enzyme. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytoplasmic microtubule organic acid metabolic process xenobiotic metabolic process coumarin 7-hydroxylase activity arachidonic acid epoxygenase activity steroid hydroxylase activity coumarin metabolic process membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway enzyme binding heme binding organelle membrane response to stilbenoid exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc009fui.1 uc009fui.2 uc009fui.3 
ENSMUST00000098658.4 Gm10655 ENSMUST00000098658.4 Gm10655 (from geneSymbol) AK155694 ENSMUST00000098658.1 ENSMUST00000098658.2 ENSMUST00000098658.3 uc292hxr.1 uc292hxr.2 uc292hxr.3 uc292hxr.1 uc292hxr.2 uc292hxr.3 
ENSMUST00000098660.10 Thsd4 ENSMUST00000098660.10 thrombospondin, type I, domain containing 4, transcript variant 1 (from RefSeq NM_001040426.3) ENSMUST00000098660.1 ENSMUST00000098660.2 ENSMUST00000098660.3 ENSMUST00000098660.4 ENSMUST00000098660.5 ENSMUST00000098660.6 ENSMUST00000098660.7 ENSMUST00000098660.8 ENSMUST00000098660.9 NM_001040426 Q3UTY6 Q8BLE5 THSD4_MOUSE uc009pyy.1 uc009pyy.2 uc009pyy.3 Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN. Isoform 2 interacts with FBN1. Isoform 2 may interact with TGFB1. [Isoform 1]: Secreted, extracellular space, extracellular matrix te=Mostly deposited into pericellular fibrillar matrices (PubMed:19940141). Colocalizes with FBN1 (PubMed:19940141). [Isoform 2]: Secreted Secreted, extracellular space, extracellular matrix te=Mostly secreted in the extracellular milieu (PubMed:19940141). In the pericellular fibrillar matrix, colocalizes with FBN1 (PubMed:19940141) (PubMed:21880733). Event=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=ADAMTSL6-alpha; IsoId=Q3UTY6-1; Sequence=Displayed; Name=2; Synonyms=ADAMTSL6-beta; IsoId=Q3UTY6-2; Sequence=VSP_030042, VSP_030043; Both isoforms are expressed in the embryo from 7 dpc through 17. Isoform 1 is widely expressed in adult tissues. Isoform 2 is detected in brain, spinal cord, eye, kidney, stomach and uterus. Mainly observed in fibrillar extracellular matrices in elastic tissues (at protein level). At 16.5 dpc, detected in fibrillar structures in various elastic tissues, including developing dermis, perichondria surrounding cartilages and the vessel walls of aortae (at protein level). At postnatal day 7 (P7), weakly expressed in the early stage dental follicle, but becomes readily detectable in assembled microfibril-like structures during the periodontal ligament-forming stage of the dental follicle and in organized microfibrils in the adult periodontal ligament (P35) (at protein level). Up-regulated in the periodontal ligament during wound healing (at protein level). microfibril protein binding extracellular region proteolysis peptidase activity hydrolase activity extracellular matrix elastic fiber assembly uc009pyy.1 uc009pyy.2 uc009pyy.3 
ENSMUST00000098663.4 Erich4 ENSMUST00000098663.4 glutamate rich 4 (from RefSeq NM_001039243.4) ENSMUST00000098663.1 ENSMUST00000098663.2 ENSMUST00000098663.3 Erich4 G5E8M5 G5E8M5_MOUSE NM_001039243 uc009ftd.1 uc009ftd.2 uc009ftd.3 uc009ftd.4 uc009ftd.5 uc009ftd.1 uc009ftd.2 uc009ftd.3 uc009ftd.4 uc009ftd.5 
ENSMUST00000098667.5 Amy2a2 ENSMUST00000098667.5 amylase 2a1 (from RefSeq NM_001411494.1) AM2A5_MOUSE Amy2 Amy2a Amy2a5 ENSMUST00000098667.1 ENSMUST00000098667.2 ENSMUST00000098667.3 ENSMUST00000098667.4 NM_001411494 P00688 Q4VBW6 Q61295 Q61296 Q64301 uc008raz.1 uc008raz.2 uc008raz.3 uc008raz.4 Reaction=Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D- glucose units.; EC=3.2.1.1; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence=; Note=Binds 1 Cl(-) ion per subunit. ; Monomer. Secreted, extracellular space. Belongs to the glycosyl hydrolase 13 family. catalytic activity alpha-amylase activity calcium ion binding extracellular region extracellular space carbohydrate metabolic process metabolic process carbohydrate catabolic process amylase activity hydrolase activity hydrolase activity, acting on glycosyl bonds chloride ion binding cation binding metal ion binding uc008raz.1 uc008raz.2 uc008raz.3 uc008raz.4 
ENSMUST00000098673.5 Amy2a5 ENSMUST00000098673.5 amylase 2a5 (from RefSeq NM_001042711.2) AM2A5_MOUSE Amy2 Amy2a Amy2a5 ENSMUST00000098673.1 ENSMUST00000098673.2 ENSMUST00000098673.3 ENSMUST00000098673.4 NM_001042711 P00688 Q4VBW6 Q61295 Q61296 Q64301 uc008raw.1 uc008raw.2 uc008raw.3 uc008raw.4 Reaction=Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D- glucose units.; EC=3.2.1.1; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence=; Note=Binds 1 Cl(-) ion per subunit. ; Monomer. Secreted, extracellular space. Belongs to the glycosyl hydrolase 13 family. catalytic activity alpha-amylase activity calcium ion binding extracellular region extracellular space carbohydrate metabolic process metabolic process carbohydrate catabolic process amylase activity hydrolase activity hydrolase activity, acting on glycosyl bonds chloride ion binding cation binding metal ion binding uc008raw.1 uc008raw.2 uc008raw.3 uc008raw.4 
ENSMUST00000098674.6 Rec114 ENSMUST00000098674.6 REC114 meiotic recombination protein (from RefSeq NM_028598.1) ENSMUST00000098674.1 ENSMUST00000098674.2 ENSMUST00000098674.3 ENSMUST00000098674.4 ENSMUST00000098674.5 NM_028598 Q9CWH4 RE114_MOUSE uc009pxh.1 uc009pxh.2 uc009pxh.3 Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:27723721, PubMed:30569039). Probably acts by forming a complex with IHO1 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721, PubMed:30569039). Required for spermatogenesis and oogenesis (PubMed:30569039). Part of the MCD recombinosome complex, at least composed of IHO1, REC114 and MEI4 (PubMed:27723721, PubMed:30569039). Forms a complex with MEI4; the interaction is required for MEI4 stability (PubMed:30569039). Interacts (via C-terminal domain) with MEI4 (via N- terminal domain) (PubMed:20551173, PubMed:30569039). Interacts with IHO1 (PubMed:27723721). Interacts with ANKRD31; the interaction is direct (PubMed:31000436, PubMed:31003867). Q9CWH4; Q8BRM6: Mei4; NbExp=5; IntAct=EBI-9548270, EBI-9548252; Chromosome Note=Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema and decreases at zygonema. Expressed in adult testis and embryonic ovary. Also expressed at low levels in liver. In the testis, expression is detected at 4 days postpartum (dpp) with a peak at day 10. Levels decrease between 14-18 dpp with an increase in the adult. Belongs to the REC114 family. protein binding cellular_component DNA recombination biological_process meiotic cell cycle uc009pxh.1 uc009pxh.2 uc009pxh.3 
ENSMUST00000098678.10 D930028M14Rik ENSMUST00000098678.10 RIKEN cDNA D930028M14 gene, transcript variant 1 (from RefSeq NR_045847.1) ENSMUST00000098678.1 ENSMUST00000098678.2 ENSMUST00000098678.3 ENSMUST00000098678.4 ENSMUST00000098678.5 ENSMUST00000098678.6 ENSMUST00000098678.7 ENSMUST00000098678.8 ENSMUST00000098678.9 NR_045847 uc009frs.1 uc009frs.2 uc009frs.3 uc009frs.4 uc009frs.5 uc009frs.6 uc009frs.1 uc009frs.2 uc009frs.3 uc009frs.4 uc009frs.5 uc009frs.6 
ENSMUST00000098682.10 Ccdc33 ENSMUST00000098682.10 coiled-coil domain containing 33, transcript variant 1 (from RefSeq NM_001166282.2) Ccdc33 E9QQ55 E9QQ55_MOUSE ENSMUST00000098682.1 ENSMUST00000098682.2 ENSMUST00000098682.3 ENSMUST00000098682.4 ENSMUST00000098682.5 ENSMUST00000098682.6 ENSMUST00000098682.7 ENSMUST00000098682.8 ENSMUST00000098682.9 NM_001166282 uc009pwd.1 uc009pwd.2 uc009pwd.3 uc009pwd.4 uc009pwd.1 uc009pwd.2 uc009pwd.3 uc009pwd.4 
ENSMUST00000098686.4 Arid3b ENSMUST00000098686.4 Transcription factor. (from UniProt F8WIN2) AK148073 Arid3b ENSMUST00000098686.1 ENSMUST00000098686.2 ENSMUST00000098686.3 F8WIN2 F8WIN2_MOUSE uc009pvu.1 uc009pvu.2 uc009pvu.3 Transcription factor. Heterodimer with ARID3A. Interacts with unphosphorylated RB1. Nucleus DNA binding nucleus uc009pvu.1 uc009pvu.2 uc009pvu.3 
ENSMUST00000098704.3 Vmn1r168 ENSMUST00000098704.3 vomeronasal 1 receptor 168 (from RefSeq NM_001166842.1) ENSMUST00000098704.1 ENSMUST00000098704.2 K7N6B6 K7N6B6_MOUSE NM_001166842 Vmn1r168 uc012fex.1 uc012fex.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fex.1 uc012fex.2 
ENSMUST00000098713.5 Smim31 ENSMUST00000098713.5 small integral membrane protein 31 (from RefSeq NM_001352886.1) ENSMUST00000098713.1 ENSMUST00000098713.2 ENSMUST00000098713.3 ENSMUST00000098713.4 NM_001352886 Q3V2G4 SIM31_MOUSE Smim31 uc009lvi.1 uc009lvi.2 uc009lvi.3 uc009lvi.4 uc009lvi.5 uc009lvi.6 Membrane ; Single-pass membrane protein membrane integral component of membrane axon uc009lvi.1 uc009lvi.2 uc009lvi.3 uc009lvi.4 uc009lvi.5 uc009lvi.6 
ENSMUST00000098720.2 Gm10665 ENSMUST00000098720.2 predicted gene 10665 (from RefSeq NM_001167160.1) ENSMUST00000098720.1 Gm10665 Gm10670 K7N6B7 K7N6B7_MOUSE NM_001167160 uc012fea.1 uc012fea.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fea.1 uc012fea.2 
ENSMUST00000098722.2 Vmn1r250 ENSMUST00000098722.2 vomeronasal 1 receptor 250 (from RefSeq NM_001167573.1) ENSMUST00000098722.1 Gm10666 K7N6B8 K7N6B8_MOUSE NM_001167573 Vmn1r250 Vmn1r93 uc009fnz.1 uc009fnz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009fnz.1 uc009fnz.2 
ENSMUST00000098736.5 Vmn1r132 ENSMUST00000098736.5 vomeronasal 1 receptor 132 (from RefSeq NM_001122682.1) E9Q1P3 E9Q8L6 E9Q8L6_MOUSE ENSMUST00000098736.1 ENSMUST00000098736.2 ENSMUST00000098736.3 ENSMUST00000098736.4 NM_001122682 Vmn1r132 Vmn1r139 uc012fdh.1 uc012fdh.2 uc012fdh.3 uc012fdh.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fdh.1 uc012fdh.2 uc012fdh.3 uc012fdh.4 
ENSMUST00000098737.2 Vmn1r114 ENSMUST00000098737.2 vomeronasal 1 receptor 114 (from RefSeq NM_001166837.1) ENSMUST00000098737.1 L7N226 L7N226_MOUSE NM_001166837 Vmn1r114 uc012fco.1 uc012fco.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fco.1 uc012fco.2 
ENSMUST00000098739.3 Vmn1r125 ENSMUST00000098739.3 vomeronasal 1 receptor 125 (from RefSeq NM_001166740.1) ENSMUST00000098739.1 ENSMUST00000098739.2 L7N227 L7N227_MOUSE NM_001166740 Vmn1r125 uc012fcz.1 uc012fcz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fcz.1 uc012fcz.2 
ENSMUST00000098744.2 Gm10670 ENSMUST00000098744.2 predicted gene 10670 (from RefSeq NM_001167161.1) ENSMUST00000098744.1 Gm10665 Gm10670 K7N6B7 K7N6B7_MOUSE NM_001167161 uc012fbz.1 uc012fbz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fbz.1 uc012fbz.2 
ENSMUST00000098747.2 Vmn1r93 ENSMUST00000098747.2 vomeronasal 1 receptor 93 (from RefSeq NM_207547.2) ENSMUST00000098747.1 Gm10666 K7N6B8 K7N6B8_MOUSE NM_207547 Vmn1r250 Vmn1r93 uc009fnu.1 uc009fnu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009fnu.1 uc009fnu.2 
ENSMUST00000098750.5 Lrif1 ENSMUST00000098750.5 ligand dependent nuclear receptor interacting factor 1, transcript variant 1 (from RefSeq NM_001039488.1) ENSMUST00000098750.1 ENSMUST00000098750.2 ENSMUST00000098750.3 ENSMUST00000098750.4 LRIF1_MOUSE NM_001039488 Q149J0 Q8C893 Q8CDD9 uc008qwk.1 uc008qwk.2 uc008qwk.3 uc008qwk.4 Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin. Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases. Interacts with RARA (By similarity). Interacts with SMCHD1; leading to recruitment to inactivated chromosome X in females (PubMed:26391951). Interacts (via PxVxL motif) with HP1 (CBX1/HP1-beta, CBX3/HP1-gamma and CBX5/HP1-alpha) (By similarity). Chromosome Nucleus matrix Note=Localizes to Barr body; recruited by SMCHD1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CDD9-1; Sequence=Displayed; Name=2; IsoId=Q8CDD9-2; Sequence=VSP_020722, VSP_020723; The Pro-Xaa-Val-Xaa-Leu (PxVxL) motif mediates interaction with HP1 (CBX1/HP1-beta, CBX3/HP1-gamma and CBX5/HP1-alpha). Belongs to the LRIF1 family. nuclear chromosome, telomeric region Barr body protein binding nucleus chromosome microtubule organizing center regulation of transcription, DNA-templated dosage compensation by inactivation of X chromosome nuclear matrix retinoic acid receptor binding uc008qwk.1 uc008qwk.2 uc008qwk.3 uc008qwk.4 
ENSMUST00000098758.5 I830077J02Rik ENSMUST00000098758.5 RIKEN cDNA I830077J02 gene (from RefSeq NM_001033780.3) B2RWJ4 CA162_MOUSE ENSMUST00000098758.1 ENSMUST00000098758.2 ENSMUST00000098758.3 ENSMUST00000098758.4 NM_001033780 Q3U7U4 uc008qvk.1 uc008qvk.2 uc008qvk.3 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc008qvk.1 uc008qvk.2 uc008qvk.3 
ENSMUST00000098760.5 Tnfaip8l3 ENSMUST00000098760.5 tumor necrosis factor, alpha-induced protein 8-like 3 (from RefSeq NM_001033535.3) ENSMUST00000098760.1 ENSMUST00000098760.2 ENSMUST00000098760.3 ENSMUST00000098760.4 NM_001033535 Q3TBL6 TP8L3_MOUSE uc009pmt.1 uc009pmt.2 uc009pmt.3 uc009pmt.4 Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling. Cytoplasm Cell membrane Note=On PDGF activation, translocates from cytoplasm to plasma membrane. Widely expressed (at protein level). The N-terminal domain (AA 2-20) is essential for its effect on cell growth and survival. Deficient mice develop normally during the first 3 months of life under pathogen-free conditions. However, following subcutaneous injection of the carcinogen 3-methylcholanthrene, deficient mice exhibit markedly delayed skin tumor onset and reduced tumor size compared with wild-type mice. Belongs to the TNFAIP8 family. nucleoplasm cytoplasm cytosol plasma membrane lipid transport phosphatidylinositol transporter activity phospholipid transport membrane regulation of lipid metabolic process phosphatidylinositol binding regulation of apoptotic process positive regulation of phosphatidylinositol 3-kinase activity inositol lipid-mediated signaling positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade uc009pmt.1 uc009pmt.2 uc009pmt.3 uc009pmt.4 
ENSMUST00000098778.3 Gm10676 ENSMUST00000098778.3 Gm10676 (from geneSymbol) AK031007 ENSMUST00000098778.1 ENSMUST00000098778.2 uc291mgq.1 uc291mgq.2 uc291mgq.1 uc291mgq.2 
ENSMUST00000098780.10 Ccdc61 ENSMUST00000098780.10 coiled-coil domain containing 61, transcript variant 9 (from RefSeq NM_001419247.1) CCD61_MOUSE Ccdc61 ENSMUST00000098780.1 ENSMUST00000098780.2 ENSMUST00000098780.3 ENSMUST00000098780.4 ENSMUST00000098780.5 ENSMUST00000098780.6 ENSMUST00000098780.7 ENSMUST00000098780.8 ENSMUST00000098780.9 Gm159 NM_001419247 Q3UJV1 VFL3 uc009fjw.1 uc009fjw.2 uc009fjw.3 Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker. In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning. During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure. Plays a non- essential role in ciliogenesis. Forms homodimers (via head domain) (By similarity). Interacts with CEP170 (By similarity). Interacts with PCM1 and CEP131 (By similarity). Binds tubulin (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cytoplasm, cytoskeleton, cilium basal body Note=Localization at the centriolar satellite is dependent on intact microtubule network. Localizes at the centriole subdistal appendages and proximal ends. Localized to centrosomal/satellite-like structures with the onset of centrosome separation in early G2. The coiled-coil domains are involved in microtubule-binding. The N-terminal 3D structure (head domain) resembles that of NHEJ1/XLF, PAXX, SASS6 and XRCC4. Belongs to the CCDC61 family. molecular_function centrosome biological_process uc009fjw.1 uc009fjw.2 uc009fjw.3 
ENSMUST00000098782.4 Layn ENSMUST00000098782.4 layilin (from RefSeq NM_001033534.1) E9QQ23 ENSMUST00000098782.1 ENSMUST00000098782.2 ENSMUST00000098782.3 LAYN_MOUSE NM_001033534 Q3TMU7 Q8C351 uc012gtc.1 uc012gtc.2 Receptor for hyaluronate. Interacts with TLN1 (By similarity). Interacts with NF2 and RDX. Membrane ; Single-pass type I membrane protein Note=Colocalizes with TLN1 at the membrane ruffles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C351-1; Sequence=Displayed; Name=2; IsoId=Q8C351-2; Sequence=VSP_021782, VSP_021783; The C-terminal domain interacts with the N-terminal domain of RDX. ruffle hyaluronic acid binding cell surface membrane integral component of membrane carbohydrate binding focal adhesion uc012gtc.1 uc012gtc.2 
ENSMUST00000098799.5 Ehd2 ENSMUST00000098799.5 EH-domain containing 2, transcript variant 1 (from RefSeq NM_153068.4) EHD2_MOUSE ENSMUST00000098799.1 ENSMUST00000098799.2 ENSMUST00000098799.3 ENSMUST00000098799.4 Ehd2 NM_153068 Q8BH64 Q8BL28 uc009fgt.1 uc009fgt.2 uc009fgt.3 ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:24508342). Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4 (PubMed:14676205). Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (PubMed:18502764, PubMed:21177873). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (By similarity). The very low intrinsic ATPase activity is increased upon interaction with liposomes. Homodimer and homooligomer (By similarity). Interacts with EHD1 (By similarity). May also interact with EHD3 and EHD4 (By similarity). Interacts with MYOF (PubMed:18502764, PubMed:21177873). Interacts with EHBP1 (PubMed:14676205). Interacts with FER1L5 (via second C2 domain) (PubMed:21177873). Interacts with CAV1 in a cholesterol-dependent manner (By similarity). Interacts (via EH domain) with PACSIN2 (via NPF motifs); this interaction probably stabilizes the caveolae (By similarity). Q8BH64; Q8BH64: Ehd2; NbExp=6; IntAct=EBI-1994334, EBI-1994334; Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane, caveola ; Peripheral membrane protein ; Cytoplasmic side Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytosol Note=Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin (PubMed:14676205). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (PubMed:18502764). Detected in lung and adipocytes. Detected at lower levels in heart and skeletal muscle. The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily. nucleotide binding calcium ion binding protein binding ATP binding GTP binding cytoplasm endosome cytosol plasma membrane caveola endocytosis endosome membrane microtubule cytoskeleton membrane hydrolase activity extrinsic component of membrane protein domain specific binding actin cytoskeleton organization cortical actin cytoskeleton organization endocytic recycling identical protein binding intercellular bridge metal ion binding perinuclear region of cytoplasm recycling endosome membrane protein localization to plasma membrane plasma membrane tubulation positive regulation of myoblast fusion positive regulation of endocytic recycling uc009fgt.1 uc009fgt.2 uc009fgt.3 
ENSMUST00000098802.10 Obox5 ENSMUST00000098802.10 oocyte specific homeobox 5 (from RefSeq NM_145709.2) ENSMUST00000098802.1 ENSMUST00000098802.2 ENSMUST00000098802.3 ENSMUST00000098802.4 ENSMUST00000098802.5 ENSMUST00000098802.6 ENSMUST00000098802.7 ENSMUST00000098802.8 ENSMUST00000098802.9 G3UZE6 G3UZS7 G3X9P6 NM_145709 OBOX5_MOUSE Obox5 Q7TPZ5 Q8VHG4 uc009fgj.1 uc009fgj.2 uc009fgj.3 Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Together with other Obox family members, required in early two-cell stage embryos to kick-start the major ZGA wave by facilitating RNA Polymerase II 'pre-configuration', during which RNA Polymerase II relocates from the initial one-cell stage binding targets to ZGA gene promoters and distal enhancers (PubMed:37459895). Mechanistically, promotes recruitment of RNA Polymerase II from (CG-rich) non-ZGA genes to (CG-poor) ZGA genes at the two-cell stage (PubMed:37459895). Binds to regulatory DNA sequences containing a 5'-ACNCCTTTAATCCCAG-3' sequence motif (PubMed:37459895). Most maternal and zygotic Obox family proteins can compensate for one another (PubMed:37459895). Nucleus Specifically expressed in oocytes and early embryos. Expressed maternally with high expression in oocytes and early embryos before expression declines after zygotic genome activation (ZGA). No visible phenotype; mice are viable and fertile (PubMed:37459895). Female mice lacking maternally transcribed Obox1, Obox2, Obox5, Obox7 as well as zygotically expressed Obox3 and Obox4 are infertile: embryos arrest at two-four cell stage due to impaired zygotic genome activation (ZGA) (PubMed:37459895). Belongs to the paired homeobox family. Obox subfamily. Sequence=AAL68804.1; Type=Erroneous gene model prediction; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding uc009fgj.1 uc009fgj.2 uc009fgj.3 
ENSMUST00000098809.4 Sult2a3 ENSMUST00000098809.4 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3 (from RefSeq NM_001101586.3) D3Z1W5 D3Z1W5_MOUSE ENSMUST00000098809.1 ENSMUST00000098809.2 ENSMUST00000098809.3 NM_001101586 Sult2a3 uc012ezs.1 uc012ezs.2 uc012ezs.3 uc012ezs.4 This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on homologous alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Belongs to the sulfotransferase 1 family. alcohol sulfotransferase activity cytoplasm cytosol drug binding sulfotransferase activity biological_process transferase activity bile-salt sulfotransferase activity steroid sulfotransferase activity 3'-phosphoadenosine 5'-phosphosulfate binding uc012ezs.1 uc012ezs.2 uc012ezs.3 uc012ezs.4 
ENSMUST00000098811.4 Bsph1 ENSMUST00000098811.4 binder of sperm protein homolog 1, transcript variant 1 (from RefSeq NM_001033418.4) B2RVZ6 BSPH1_MOUSE ENSMUST00000098811.1 ENSMUST00000098811.2 ENSMUST00000098811.3 Gm767 NM_001033418 Q3UW26 uc009ffw.1 uc009ffw.2 uc009ffw.3 uc009ffw.4 This gene encodes a member of the binder of sperm family. The encoded protein may be involved in sperm capacitation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. Binds sperm in vitro and promotes sperm capacitation (PubMed:22539676, PubMed:24307707). Specifically promotes capacitation induced by high density lipoproteins (HDLs) (PubMed:25602034). Also binds heparin, phospholipid liposomes, and weakly to gelatin (PubMed:22539676). Does not bind chondroitin sulfate B (PubMed:22539676). Secreted Expressed only in the epididymis. Belongs to the seminal plasma protein family. extracellular region extracellular space single fertilization heparin binding cell surface sperm capacitation uc009ffw.1 uc009ffw.2 uc009ffw.3 uc009ffw.4 
ENSMUST00000098816.10 Slc7a2 ENSMUST00000098816.10 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2, transcript variant 2 (from RefSeq NM_001044740.2) Atrc2 CTR2_MOUSE E9QPL9 ENSMUST00000098816.1 ENSMUST00000098816.2 ENSMUST00000098816.3 ENSMUST00000098816.4 ENSMUST00000098816.5 ENSMUST00000098816.6 ENSMUST00000098816.7 ENSMUST00000098816.8 ENSMUST00000098816.9 NM_001044740 P18581 Q38RA6 Q3TB99 Q3U3R5 Slc7a2 Tea uc009lng.1 uc009lng.2 uc009lng.3 Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L- homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:8195186, PubMed:8385111, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (PubMed:16670299). [Isoform 1]: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L- arginine, L-lysine, L-ornithine and L-homoarginine). [Isoform 2]: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L- ornithine and L-homoarginine). Shows a much higher affinity for L- arginine than isoform 1. [Isoform 1]: Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143, ChEBI:CHEBI:32682; Evidence= [Isoform 2]: Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143, ChEBI:CHEBI:32682; Evidence= Reaction=L-lysine(in) = L-lysine(out); Xref=Rhea:RHEA:70935, ChEBI:CHEBI:32551; Evidence=; Reaction=L-ornithine(in) = L-ornithine(out); Xref=Rhea:RHEA:71199, ChEBI:CHEBI:46911; Evidence=; Reaction=L-homoarginine(in) = L-homoarginine(out); Xref=Rhea:RHEA:71203, ChEBI:CHEBI:143006; Evidence=; [Isoform 1]: Kinetic parameters: KM=2.1 mM for L-arginine ; KM=2.7 mM for L-arginine ; Note=KM is between 2.15 and 5.2 mM for L-arginine. ; [Isoform 2]: Kinetic parameters: KM=0.25 mM for L-arginine ; KM=0.038 mM for L-arginine ; Cell membrane ulti-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha, CAT-2A ; IsoId=P18581-1; Sequence=Displayed; Name=2; Synonyms=Beta, CAT-2B ; IsoId=P18581-2; Sequence=VSP_000025; Detected in liver (at protein level) (PubMed:8385111). Highest expression in liver and T-cells. Also expressed in brain and lung. By macrophage activation. N-glycosylated. Intracellular polyamine levels are reduced in hepatocytes. Infection of knockout mice with parasite P.berghei (ANKA strain) sporozoites results in a reduction in the parasite load in the liver compared to wild type mice. [Isoform 2]: Affinity of isoform 2 for arginine uptake is 70-fold higher than for isoform 1. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. L-ornithine transmembrane transporter activity nitric oxide production involved in inflammatory response high-affinity arginine transmembrane transporter activity high-affinity lysine transmembrane transporter activity plasma membrane nitric oxide biosynthetic process amino acid transport arginine transmembrane transporter activity L-lysine transmembrane transporter activity arginine transport membrane integral component of membrane transmembrane transporter activity cell junction macrophage activation regulation of macrophage activation regulation of inflammatory response transmembrane transport L-arginine transmembrane transporter activity low-affinity L-arginine transmembrane transporter activity high-affinity L-ornithine transmembrane transporter activity L-arginine import across plasma membrane L-lysine import across plasma membrane L-ornithine import across plasma membrane L-arginine transport L-ornithine transmembrane transport L-lysine transmembrane transport uc009lng.1 uc009lng.2 uc009lng.3 
ENSMUST00000098817.4 Vps37a ENSMUST00000098817.4 vacuolar protein sorting 37A (from RefSeq NM_033560.3) ENSMUST00000098817.1 ENSMUST00000098817.2 ENSMUST00000098817.3 NM_033560 Q0VGD1 Q3TBI5 Q3TC15 Q3TC26 Q8CHS8 VP37A_MOUSE uc009lmy.1 uc009lmy.2 uc009lmy.3 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity). Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28 and HGS. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry (By similarity). Late endosome membrane ; Peripheral membrane protein Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CHS8-1; Sequence=Displayed; Name=2; IsoId=Q8CHS8-2; Sequence=VSP_025370, VSP_025371; Name=3; IsoId=Q8CHS8-3; Sequence=VSP_025372; Belongs to the VPS37 family. ESCRT I complex molecular_function nucleus nucleoplasm endosome centrosome cytosol protein targeting to membrane protein targeting to vacuole protein transport membrane late endosome membrane endosome transport via multivesicular body sorting pathway ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway intracellular membrane-bounded organelle uc009lmy.1 uc009lmy.2 uc009lmy.3 
ENSMUST00000098822.10 Zfp606 ENSMUST00000098822.10 zinc finger protein 606, transcript variant 1 (from RefSeq NM_026112.4) ENSMUST00000098822.1 ENSMUST00000098822.2 ENSMUST00000098822.3 ENSMUST00000098822.4 ENSMUST00000098822.5 ENSMUST00000098822.6 ENSMUST00000098822.7 ENSMUST00000098822.8 ENSMUST00000098822.9 NM_026112 Q7TSV0 Q7TSV0_MOUSE Zfp606 uc009fec.1 uc009fec.2 uc009fec.3 uc009fec.4 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding nucleus regulation of transcription, DNA-templated metal ion binding uc009fec.1 uc009fec.2 uc009fec.3 uc009fec.4 
ENSMUST00000098825.5 AI429214 ENSMUST00000098825.5 expressed sequence AI429214 (from RefSeq NM_001039220.3) CH048_MOUSE ENSMUST00000098825.1 ENSMUST00000098825.2 ENSMUST00000098825.3 ENSMUST00000098825.4 NM_001039220 Q3TTJ4 uc009llx.1 uc009llx.2 uc009llx.3 uc009llx.4 molecular_function cellular_component biological_process uc009llx.1 uc009llx.2 uc009llx.3 uc009llx.4 
ENSMUST00000098827.3 Gm10684 ENSMUST00000098827.3 predicted gene 10684 (from RefSeq NR_033547.1) ENSMUST00000098827.1 ENSMUST00000098827.2 NR_033547 uc012gsb.1 uc012gsb.2 uc012gsb.1 uc012gsb.2 
ENSMUST00000098837.3 Foxr1 ENSMUST00000098837.3 forkhead box R1 (from RefSeq NM_001033469.2) ENSMUST00000098837.1 ENSMUST00000098837.2 FOXR1_MOUSE Foxn5 Gm1115 NM_001033469 Q3UTB7 uc009pdr.1 uc009pdr.2 uc009pdr.3 Transcription factor which acts as both an activator and a repressor (By similarity). Activates transcription of a number of genes including the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 which are involved in protection against oxidative stress (By similarity). Required for normal brain development (PubMed:34723967). Nucleus Cytoplasm Cytoplasm, perinuclear region Note=Localizes to the nucleus and cytoplasm with higher levels in the nucleus where it is expressed in a diffuse manner (PubMed:34723967). Located in the cytoplasm of spermatocytes and strongly accumulates at the perinuclear region in elongated spermatids (PubMed:25609838). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UTB7-1; Sequence=Displayed; Name=2; IsoId=Q3UTB7-2; Sequence=VSP_021113, VSP_021114; Expressed in adult germ cells (at protein level) (PubMed:25609838). Expressed in heart, liver, lung and embryonic brain (PubMed:34723967). Weakly expressed in embryonic gonads. Reduced survival with the majority of mutants dying during embryonic development and only 23.5% of mutants living to postnatal day 21 (PubMed:34723967). Surviving newborns are smaller and lighter than their wild-type littermates (PubMed:34723967). Newborn brains display decreased cortical thickness and enlarged ventricles (PubMed:34723967). DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc009pdr.1 uc009pdr.2 uc009pdr.3 
ENSMUST00000098842.3 Tti2 ENSMUST00000098842.3 TELO2 interacting protein 2, transcript variant 1 (from RefSeq NR_103719.1) ENSMUST00000098842.1 ENSMUST00000098842.2 NR_103719 Q3UTH3 Q8BGV4 Q8VE31 TTI2_MOUSE uc009ljh.1 uc009ljh.2 uc009ljh.3 uc009ljh.4 Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs (By similarity). Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with TELO2 and TTI1. Interacts with WAC; WAC positively regulates MTOR activity by promoting the assembly of the TTT complex and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex which leads to the dimerization of the mTORC1 complex and its subsequent activation. Belongs to the TTI2 family. molecular_function nucleoplasm centrosome cytosol biological_process ASTRA complex uc009ljh.1 uc009ljh.2 uc009ljh.3 uc009ljh.4 
ENSMUST00000098843.3 H3c13 ENSMUST00000098843.3 H3 clustered histone 13 (from RefSeq NM_178215.2) A3KMN6 ENSMUST00000098843.1 ENSMUST00000098843.2 H3-143 H3-53 H3-B H3-F H3.2 H3.2-221 H3.2-614 H3.2-615 H3.2-616 H32_MOUSE H3b H3c13 H3c14 H3c15 H3c2 H3c3 H3c4 H3c6 H3c7 H3f Hist1h3b Hist1h3c Hist1h3d Hist1h3e Hist1h3f Hist2h3b Hist2h3c1 Hist2h3c2 Hist2h3ca1 Hist2h3ca2 NM_178215 P02295 P02297 P16105 P17269 P17320 P84228 Q60582 Q78E59 Q8CGN9 uc008qmo.1 uc008qmo.2 uc008qmo.3 uc008qmo.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer (By similarity). Interacts with DNAJC9, CHAF1A and CHAF1B (By similarity). P84228; Q8TF76-1: HASPIN; Xeno; NbExp=3; IntAct=EBI-2658213, EBI-15815652; Nucleus. Chromosome. Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity). Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys- 10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H3 family. Sequence=AAH94041.1; Type=Erroneous initiation; Evidence=; Sequence=AAO06264.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter nuclear chromosome chromatin nucleosome nuclear nucleosome DNA binding chromatin binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly macromolecular complex protein heterodimerization activity protein heterotetramerization regulation of gene silencing uc008qmo.1 uc008qmo.2 uc008qmo.3 uc008qmo.4 
ENSMUST00000098845.10 Epn1 ENSMUST00000098845.10 epsin 1, transcript variant 1 (from RefSeq NM_010147.5) ENSMUST00000098845.1 ENSMUST00000098845.2 ENSMUST00000098845.3 ENSMUST00000098845.4 ENSMUST00000098845.5 ENSMUST00000098845.6 ENSMUST00000098845.7 ENSMUST00000098845.8 ENSMUST00000098845.9 EPN1_MOUSE NM_010147 O70446 Q6NX78 Q80VP1 uc009ezx.1 uc009ezx.2 uc009ezx.3 Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (By similarity). Monomer. Binds clathrin and ZBTB16/ZNF145 (By similarity). Binds ubiquitinated proteins (By similarity). Interacts with RALBP1 in a complex also containing NUMB and TFAP2A during interphase and mitosis (By similarity). Interacts with AP2B1 (By similarity). Interacts with UBQLN2 (By similarity). Interacts with ITSN1. Interacts with AP2A1 and AP2A2. Interacts with REPS2; the interaction is direct (By similarity). Interacts with EPS15; the interaction is direct (By similarity). Interacts with ENTREP1 (By similarity). Cytoplasm Cell membrane ; Peripheral membrane protein Nucleus Membrane, clathrin-coated pit Note=Associated with the cytoplasmic membrane at sites where clathrin- coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80VP1-1; Sequence=Displayed; Name=2; IsoId=Q80VP1-2; Sequence=VSP_009153; The NPF repeat domain is involved in EPS15 binding. The DPW repeat domain is involved in AP2A2 and clathrin binding. The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1. Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation. Ubiquitinated. Belongs to the epsin family. Name=Protein Spotlight; Note=The bubble's bend - Issue 42 of January 2004; URL="https://web.expasy.org/spotlight/back_issues/042"; in utero embryonic development nucleus cytoplasm cytosol plasma membrane clathrin-coated pit endocytosis Notch signaling pathway female pregnancy transcription factor binding lipid binding membrane extrinsic component of cytoplasmic side of plasma membrane clathrin adaptor activity ion channel binding embryonic organ development presynapse postsynapse extrinsic component of presynaptic membrane extrinsic component of postsynaptic membrane negative regulation of sprouting angiogenesis positive regulation of clathrin coat assembly uc009ezx.1 uc009ezx.2 uc009ezx.3 
ENSMUST00000098853.9 Kmt5c ENSMUST00000098853.9 lysine methyltransferase 5C, transcript variant 2 (from RefSeq NM_001115018.2) ENSMUST00000098853.1 ENSMUST00000098853.2 ENSMUST00000098853.3 ENSMUST00000098853.4 ENSMUST00000098853.5 ENSMUST00000098853.6 ENSMUST00000098853.7 ENSMUST00000098853.8 KMT5C_MOUSE Kmt5c NM_001115018 Q5RKP6 Q6Q783 Q8R1C5 Suv420h2 uc009eyi.1 uc009eyi.2 uc009eyi.3 uc009eyi.4 Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:15145825, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (PubMed:15145825). Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions (PubMed:15145825). KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (PubMed:15750587, PubMed:16612004). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). Reaction=N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60348, Rhea:RHEA-COMP:15555, Rhea:RHEA- COMP:15556, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; EC=2.1.1.362; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60349; Evidence=; Reaction=N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L- methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61992, Rhea:RHEA- COMP:15556, Rhea:RHEA-COMP:15998, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961, ChEBI:CHEBI:61976; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61993; Evidence=; Reaction=L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60344, Rhea:RHEA-COMP:15554, Rhea:RHEA-COMP:15555, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.361; Evidence=; Inhibited by 6,7-Dichloro-N-cyclopentyl-4- (pyridin-4-yl)phthalazin-1-amine (A-196). Kinetic parameters: KM=510 uM for histone H4K20me1 peptide ; Homodimer (PubMed:24049080). Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2. Nucleus Chromosome Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily. Sequence=AAH24816.1; Type=Erroneous initiation; Evidence=; Sequence=AAH85473.2; Type=Erroneous initiation; Evidence=; condensed nuclear chromosome, centromeric region nucleus nucleoplasm chromosome nuclear heterochromatin pericentric heterochromatin chromatin organization methyltransferase activity histone methylation transferase activity histone-lysine N-methyltransferase activity methylation histone H4-K20 trimethylation histone methyltransferase activity (H4-K20 specific) uc009eyi.1 uc009eyi.2 uc009eyi.3 uc009eyi.4 
ENSMUST00000098858.11 Kcnu1 ENSMUST00000098858.11 potassium channel, subfamily U, member 1 (from RefSeq NM_008432.3) ENSMUST00000098858.1 ENSMUST00000098858.10 ENSMUST00000098858.2 ENSMUST00000098858.3 ENSMUST00000098858.4 ENSMUST00000098858.5 ENSMUST00000098858.6 ENSMUST00000098858.7 ENSMUST00000098858.8 ENSMUST00000098858.9 G3X9P7 G3X9P7_MOUSE Kcnu1 NM_008432 uc009lhe.1 uc009lhe.2 uc009lhe.3 Membrane ; Multi- pass membrane protein ion channel activity ion transport potassium ion transport membrane integral component of membrane ion transmembrane transport transmembrane transport uc009lhe.1 uc009lhe.2 uc009lhe.3 
ENSMUST00000098859.10 Tnni3 ENSMUST00000098859.10 troponin I, cardiac 3 (from RefSeq NM_009406.4) ENSMUST00000098859.1 ENSMUST00000098859.2 ENSMUST00000098859.3 ENSMUST00000098859.4 ENSMUST00000098859.5 ENSMUST00000098859.6 ENSMUST00000098859.7 ENSMUST00000098859.8 ENSMUST00000098859.9 NM_009406 Q497F1 Q497F1_MOUSE Tnni3 uc009exv.1 uc009exv.2 uc009exv.3 Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Belongs to the troponin I family. actin binding cytoplasm troponin complex regulation of smooth muscle contraction regulation of cardiac muscle contraction by calcium ion signaling calcium channel inhibitor activity protein kinase binding protein domain specific binding myofibril sarcomere troponin C binding troponin T binding negative regulation of ATPase activity contractile fiber calcium-dependent protein binding actin filament binding ventricular cardiac muscle tissue morphogenesis heart contraction cardiac muscle contraction cardiac myofibril cardiac Troponin complex uc009exv.1 uc009exv.2 uc009exv.3 
ENSMUST00000098867.4 6330562C20Rik ENSMUST00000098867.4 6330562C20Rik (from geneSymbol) AK144859 ENSMUST00000098867.1 ENSMUST00000098867.2 ENSMUST00000098867.3 uc008qji.1 uc008qji.2 uc008qji.3 uc008qji.4 uc008qji.1 uc008qji.2 uc008qji.3 uc008qji.4 
ENSMUST00000098879.2 Tdpoz5 ENSMUST00000098879.2 TD and POZ domain containing 5 (from RefSeq NM_207273.2) E0CYU8 E0CYU8_MOUSE E9QLP9 ENSMUST00000098879.1 NM_207273 Tdpoz5 Tdpoz7 uc012ctj.1 uc012ctj.2 Belongs to the Tdpoz family. molecular_function cellular_component biological_process uc012ctj.1 uc012ctj.2 
ENSMUST00000098886.5 Lce3e ENSMUST00000098886.5 late cornified envelope 3E (from RefSeq NM_001254725.1) 2310001H18Rik ENSMUST00000098886.1 ENSMUST00000098886.2 ENSMUST00000098886.3 ENSMUST00000098886.4 F8VQJ0 F8VQJ0_MOUSE Lce3e NM_001254725 uc029unk.1 uc029unk.2 Belongs to the LCE family. epidermis development uc029unk.1 uc029unk.2 
ENSMUST00000098887.4 Defa28 ENSMUST00000098887.4 defensin, alpha, 28 (from RefSeq NM_001177523.1) D3Z1V9 D3Z1V9_MOUSE Defa28 ENSMUST00000098887.1 ENSMUST00000098887.2 ENSMUST00000098887.3 NM_001177523 uc012gay.1 uc012gay.2 uc012gay.3 Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc012gay.1 uc012gay.2 uc012gay.3 
ENSMUST00000098888.7 Smcp ENSMUST00000098888.7 sperm mitochondria-associated cysteine-rich protein (from RefSeq NM_008574.4) ENSMUST00000098888.1 ENSMUST00000098888.2 ENSMUST00000098888.3 ENSMUST00000098888.4 ENSMUST00000098888.5 ENSMUST00000098888.6 MCSP_MOUSE Mcs Mcsp NM_008574 O70613 P15265 Q6P8N3 uc008qeg.1 uc008qeg.2 uc008qeg.3 uc008qeg.4 Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida. Cytoplasm Mitochondrion membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis. Testis. Is selectively expressed in the spermatids of seminiferous tubules. First detected in step 11 spermatids. Levels increase in subsequent steps to reach a maximum in late step 15 and early step 16. Levels decrease in late step 16. Was originally (PubMed:2303168, PubMed:1418626) thought to be a selenoprotein and was known as sperm mitochondrial capsule selenoprotein. Sequence=AAB08438.2; Type=Erroneous initiation; Evidence=; Sequence=AAC08283.1; Type=Erroneous initiation; Evidence=; Sequence=AAH55104.2; Type=Erroneous initiation; Evidence=; Sequence=AAH61167.1; Type=Erroneous initiation; Evidence=; Sequence=BAE43359.1; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm mitochondrion mitochondrial outer membrane single fertilization binding of sperm to zona pellucida penetration of zona pellucida membrane flagellated sperm motility mitochondrial membrane uc008qeg.1 uc008qeg.2 uc008qeg.3 uc008qeg.4 
ENSMUST00000098890.4 Defa29 ENSMUST00000098890.4 defensin, alpha, 29 (from RefSeq NM_007844.3) Defa-rs1 Defa29 Defcr-rs1 ENSMUST00000098890.1 ENSMUST00000098890.2 ENSMUST00000098890.3 NM_007844 Q9D815 Q9D815_MOUSE uc009lbp.1 uc009lbp.2 uc009lbp.3 Secreted extracellular region extracellular space defense response uc009lbp.1 uc009lbp.2 uc009lbp.3 
ENSMUST00000098892.5 Defa5 ENSMUST00000098892.5 defensin, alpha, 5 (from RefSeq NM_007851.2) Defa5 ENSMUST00000098892.1 ENSMUST00000098892.2 ENSMUST00000098892.3 ENSMUST00000098892.4 L7N230 L7N230_MOUSE NM_007851 uc009lbo.1 uc009lbo.2 uc009lbo.3 Secreted Belongs to the alpha-defensin family. extracellular region extracellular space defense response defense response to bacterium uc009lbo.1 uc009lbo.2 uc009lbo.3 
ENSMUST00000098893.4 Defa3 ENSMUST00000098893.4 defensin, alpha, 3 (from RefSeq NM_007850.2) DEFA3_MOUSE Defcr3 ENSMUST00000098893.1 ENSMUST00000098893.2 ENSMUST00000098893.3 NM_007850 P28310 Q499K7 uc009lbn.1 uc009lbn.2 uc009lbn.3 Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Secreted. Paneth cells of the small bowel. Belongs to the alpha-defensin family. innate immune response in mucosa extracellular region extracellular space defense response antibacterial humoral response response to drug defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc009lbn.1 uc009lbn.2 uc009lbn.3 
ENSMUST00000098895.3 Defa40 ENSMUST00000098895.3 defensin, alpha, 40 (from RefSeq NM_001177487.2) Defa40 ENSMUST00000098895.1 ENSMUST00000098895.2 Gm15292 L7N231 L7N231_MOUSE NM_001177487 uc012gau.1 uc012gau.2 uc012gau.3 Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc012gau.1 uc012gau.2 uc012gau.3 
ENSMUST00000098896.5 Defa31 ENSMUST00000098896.5 defensin, alpha, 31 (from RefSeq NM_007848.2) DFA23_MOUSE Defa23 Defcr23 ENSMUST00000098896.1 ENSMUST00000098896.2 ENSMUST00000098896.3 ENSMUST00000098896.4 NM_007848 Q059S0 Q5G866 uc009lbm.1 uc009lbm.2 uc009lbm.3 uc009lbm.4 May have microbicidal activities. Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc009lbm.1 uc009lbm.2 uc009lbm.3 uc009lbm.4 
ENSMUST00000098897.2 Defa22 ENSMUST00000098897.2 defensin, alpha, 22 (from RefSeq NM_207658.4) Defa22 ENSMUST00000098897.1 NM_207658 W4VSN6 W4VSN6_MOUSE uc009lbl.1 uc009lbl.2 uc009lbl.3 Secreted Belongs to the alpha-defensin family. extracellular region extracellular space defense response defense response to bacterium uc009lbl.1 uc009lbl.2 uc009lbl.3 
ENSMUST00000098898.5 Defa30 ENSMUST00000098898.5 defensin, alpha, 30 (from RefSeq NM_001177485.2) Defa30 E9QPZ2 E9QPZ2_MOUSE ENSMUST00000098898.1 ENSMUST00000098898.2 ENSMUST00000098898.3 ENSMUST00000098898.4 NM_001177485 uc012gas.1 uc012gas.2 uc012gas.3 Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc012gas.1 uc012gas.2 uc012gas.3 
ENSMUST00000098899.4 Defa23 ENSMUST00000098899.4 defensin, alpha, 23 (from RefSeq NM_001012307.2) DFA23_MOUSE Defcr23 ENSMUST00000098899.1 ENSMUST00000098899.2 ENSMUST00000098899.3 NM_001012307 Q059S0 Q5G866 uc009lbk.1 uc009lbk.2 uc009lbk.3 uc009lbk.4 uc009lbk.5 May have microbicidal activities. Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc009lbk.1 uc009lbk.2 uc009lbk.3 uc009lbk.4 uc009lbk.5 
ENSMUST00000098900.3 Pate9 ENSMUST00000098900.3 prostate and testis expressed 9 (from RefSeq NM_001033783.2) EG434396 ENSMUST00000098900.1 ENSMUST00000098900.2 Gm5615 NM_001033783 Pate9 Q3UW02 Q3UW02_MOUSE uc009otq.1 uc009otq.2 uc009otq.3 molecular_function cellular_component biological_process uc009otq.1 uc009otq.2 uc009otq.3 
ENSMUST00000098908.4 Defb33 ENSMUST00000098908.4 defensin beta 33 (from RefSeq NM_001039119.2) DFB33_MOUSE ENSMUST00000098908.1 ENSMUST00000098908.2 ENSMUST00000098908.3 NM_001039119 Q30KN3 uc009oah.1 uc009oah.2 uc009oah.3 uc009oah.4 Has antibacterial activity. Secreted Belongs to the beta-defensin family. extracellular region extracellular space chemotaxis defense response CCR6 chemokine receptor binding chemoattractant activity defense response to bacterium positive chemotaxis cell chemotaxis uc009oah.1 uc009oah.2 uc009oah.3 uc009oah.4 
ENSMUST00000098909.5 Potefam3e ENSMUST00000098909.5 POTE ankyrin domain family member 3E (from RefSeq NM_001039553.2) D3Z1P8 D3Z1P8_MOUSE ENSMUST00000098909.1 ENSMUST00000098909.2 ENSMUST00000098909.3 ENSMUST00000098909.4 NM_001039553 Potefam3e uc012gai.1 uc012gai.2 uc012gai.3 uc012gai.4 molecular_function cellular_component biological_process uc012gai.1 uc012gai.2 uc012gai.3 uc012gai.4 
ENSMUST00000098911.10 S100a16 ENSMUST00000098911.10 S100 calcium binding protein A16, transcript variant 4 (from RefSeq NM_001356608.1) ENSMUST00000098911.1 ENSMUST00000098911.2 ENSMUST00000098911.3 ENSMUST00000098911.4 ENSMUST00000098911.5 ENSMUST00000098911.6 ENSMUST00000098911.7 ENSMUST00000098911.8 ENSMUST00000098911.9 NM_001356608 Q3TVE3 Q9D708 S100a16 S10AG_MOUSE uc008qcw.1 uc008qcw.2 uc008qcw.3 Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro). Overexpression in 3T3-L1 preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (PubMed:21266506, PubMed:23526364). Homodimer (PubMed:17030513). Interacts with TP53 (PubMed:21266506). Nucleus, nucleolus toplasm te=Primarily nucleolar. A high intracellular calcium level induces nucleolar exit and nucleocytoplasmic transport, whereas a low intracellular calcium level leads to nuclear translocation and accumulation within specific region of nucleoli (PubMed:17030513). Ubiquitous (PubMed:17030513). Widely distributed throughout the adult brain and predominantly expressed within specific astrocyte populations (PubMed:17030513). Expressed at high level in adipose tissues of obese animals (PubMed:21266506). S100A16 proteins, but not other S100 proteins, have only one functional Ca(2+) binding site per monomer (PubMed:14684152, PubMed:17030513). Upon Ca(2+) binding, undergoes conformational changes leading to the exposure of hydrophobic patches which could be implicated in the Ca(2+)-dependent nuclear export. Binds Zn(2+) (PubMed:17030513). Ca(2+) and Zn(2+) do not bind to the same site (PubMed:17030513). Does not bind Cu(2+) (PubMed:17030513). Belongs to the S-100 family. calcium ion binding extracellular space nucleus nucleolus cytoplasm cytosol plasma membrane protein homodimerization activity metal ion binding response to calcium ion uc008qcw.1 uc008qcw.2 uc008qcw.3 
ENSMUST00000098914.10 Dennd4b ENSMUST00000098914.10 DENN domain containing 4B, transcript variant 1 (from RefSeq NM_201407.4) A0A0R4J172 A0A0R4J172_MOUSE Dennd4b ENSMUST00000098914.1 ENSMUST00000098914.2 ENSMUST00000098914.3 ENSMUST00000098914.4 ENSMUST00000098914.5 ENSMUST00000098914.6 ENSMUST00000098914.7 ENSMUST00000098914.8 ENSMUST00000098914.9 NM_201407 uc008qbx.1 uc008qbx.2 uc008qbx.3 uc008qbx.4 uc008qbx.5 nucleus Golgi apparatus Rab guanyl-nucleotide exchange factor activity regulation of Rab protein signal transduction uc008qbx.1 uc008qbx.2 uc008qbx.3 uc008qbx.4 uc008qbx.5 
ENSMUST00000098916.4 Gm10699 ENSMUST00000098916.4 Gm10699 (from geneSymbol) AK134595 ENSMUST00000098916.1 ENSMUST00000098916.2 ENSMUST00000098916.3 uc291ylc.1 uc291ylc.2 uc291ylc.3 uc291ylc.1 uc291ylc.2 uc291ylc.3 
ENSMUST00000098926.3 Gm10701 ENSMUST00000098926.3 predicted gene 10701 (from RefSeq NR_188825.1) ENSMUST00000098926.1 ENSMUST00000098926.2 NR_188825 uc292fgq.1 uc292fgq.2 uc292fgq.1 uc292fgq.2 
ENSMUST00000098942.6 Spc24 ENSMUST00000098942.6 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae), transcript variant 4 (from RefSeq NR_151673.1) ENSMUST00000098942.1 ENSMUST00000098942.2 ENSMUST00000098942.3 ENSMUST00000098942.4 ENSMUST00000098942.5 NR_151673 Q3TIF5 Q8CD13 Q9D083 SPC24_MOUSE Spbc24 uc009oml.1 uc009oml.2 uc009oml.3 Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end (By similarity). Nucleus Chromosome, centromere, kinetochore Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D083-1; Sequence=Displayed; Name=2; IsoId=Q9D083-2; Sequence=VSP_020516, VSP_020517; Name=3; IsoId=Q9D083-3; Sequence=VSP_020515; Belongs to the SPC24 family. chromosome, centromeric region kinetochore condensed chromosome kinetochore molecular_function nucleus chromosome nucleolus cell cycle Ndc80 complex cell division uc009oml.1 uc009oml.2 uc009oml.3 
ENSMUST00000098950.6 Elavl1 ENSMUST00000098950.6 ELAV like RNA binding protein 1 (from RefSeq NM_010485.3) ELAV1_MOUSE ENSMUST00000098950.1 ENSMUST00000098950.2 ENSMUST00000098950.3 ENSMUST00000098950.4 ENSMUST00000098950.5 Elra Hua NM_010485 P70372 Q60745 Q78QY3 uc009kts.1 uc009kts.2 uc009kts.3 RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (PubMed:24394384). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (By similarity). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (PubMed:21402775). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:27616329). Monomer and homodimer (in vitro). Interacts with ANP32A (By similarity). Interacts with ZNF385A; the interaction is indirect and mRNA-dependent and may regulate p53/TP53 expression (PubMed:21402775). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with AGO1 and AGO2. Interacts with IGF2BP1. Interacts with IGF2BP2 and IGF2BP3. Interacts with HNRNPL (By similarity). Interacts with DHX36; this interaction occurs in a RNA-dependent manner. Interacts with ILF3; this interaction occurs in a RNA-dependent manner (By similarity). Interacts with PLEKHN1 (By similarity). Interacts with SHFL; the interaction increases in presence of RNA (By similarity). Interacts with YBX1; interaction recruits ELAVL1 on C5- methylcytosine (m5C)-containing mRNAs, thereby promoting mRNA stability (By similarity). Interacts with FXR1 (By similarity). P70372; Q03160: Grb7; NbExp=7; IntAct=EBI-6877056, EBI-7100053; P70372; Q80ZW7: Tia1; NbExp=2; IntAct=EBI-6877056, EBI-7809240; P70372; P62960: Ybx1; NbExp=5; IntAct=EBI-6877056, EBI-529779; Cytoplasm Nucleus Cytoplasm, Stress granule Cytoplasm, P-body Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2. Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (By similarity). Localizes to the stress granules in the presence of PLEKHN1. The first RRM (RNA recognition motif) domain is essential for binding to AU-rich elements. Phosphorylated by MAPKAPK2. Phosphorylated by PRKCD. Methylated at Arg-217 by CARM1 in T-cells in response to LPS challenge. Belongs to the RRM elav family. nucleic acid binding RNA binding double-stranded RNA binding mRNA binding mRNA 3'-UTR binding protein binding nucleus nucleoplasm cytoplasm cytosol cytoplasmic stress granule AU-rich element binding protein kinase binding miRNA binding mRNA 3'-UTR AU-rich region binding protein homodimerization activity positive regulation of translation mRNA stabilization protein homooligomerization negative regulation of gene silencing by miRNA 3'-UTR-mediated mRNA stabilization postsynapse glutamatergic synapse ribonucleoprotein complex regulation of stem cell population maintenance uc009kts.1 uc009kts.2 uc009kts.3 
ENSMUST00000098956.3 Bglap2 ENSMUST00000098956.3 bone gamma-carboxyglutamate protein 2 (from RefSeq NM_001032298.3) ENSMUST00000098956.1 ENSMUST00000098956.2 NM_001032298 OSTC2_MOUSE P04641 P86547 uc008pux.1 uc008pux.2 uc008pux.3 uc008pux.4 This gene encodes a preproprotein that is proteolytically processed to generate a mature protein product. This protein product is a hormone that is secreted by osteoblasts and may function in bone remodeling and energy metabolism. Homozygous knockout mice for this gene exhibit a gradual increase in bone size, density and strength, as well as elevated adiposity and impaired glucose tolerance. This gene is present in a gene cluster with other related genes on chromosome 3. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CJ326623.1, CJ326788.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (PubMed:8684484). The carboxylated form binds strongly to apatite and calcium (PubMed:17693256). The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development (PubMed:17693256, PubMed:20655470, PubMed:20655471, PubMed:21333348, PubMed:24074871). Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure (PubMed:17693256, PubMed:20655470, PubMed:20655471). Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein- coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (PubMed:21333348). Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA) (PubMed:24074871, PubMed:28851741). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development (PubMed:24074871). Secreted Bone. Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation by GGCX (By similarity). These residues are essential for the binding of calcium (By similarity). Carboxylated in a Ptprv/Esp- dependent process (PubMed:17693256, PubMed:20655470, PubMed:20655471). Decarboxylation promotes the hormone activity (PubMed:17693256, PubMed:20655470, PubMed:20655471, PubMed:21333348, PubMed:24074871). Mice lacking Bglap and Bglap2 show increased bone formation, characterized by higher bone mass and bones of improved functional quality (PubMed:8684484). Mice lacking Bglap and Bglap2 also display reduced male fertility due to decreased testosterone production in the testes (PubMed:21333348). Mice lacking Bglap and Bglap2 are passive and show greater anxiety-like behaviors due to impaired synthesis of neurotransmitters (PubMed:24074871). Belongs to the osteocalcin/matrix Gla protein family. ossification osteoblast differentiation calcium ion binding extracellular region extracellular space cytoplasm rough endoplasmic reticulum Golgi apparatus structural constituent of bone dendrite regulation of bone mineralization pancreas development biomineral tissue development vesicle positive regulation of insulin secretion response to vitamin K cellular response to insulin stimulus glucose homeostasis cell projection perikaryon cellular lipid catabolic process type B pancreatic cell proliferation hydroxyapatite binding metal ion binding bone development regulation of cellular response to insulin stimulus uc008pux.1 uc008pux.2 uc008pux.3 uc008pux.4 
ENSMUST00000099001.5 Zfp1003 ENSMUST00000099001.5 Zfp1003 (from geneSymbol) BC099593 ENSMUST00000099001.1 ENSMUST00000099001.2 ENSMUST00000099001.3 ENSMUST00000099001.4 F6QUW6 F6QUW6_MOUSE Gm14327 uc290dgr.1 uc290dgr.2 uc290dgr.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process uc290dgr.1 uc290dgr.2 uc290dgr.3 
ENSMUST00000099007.3 Gm14296 ENSMUST00000099007.3 predicted gene 14296, transcript variant 2 (from RefSeq NM_001305133.1) 2210418O10Rik A2ARL4 A2ARL4_MOUSE ENSMUST00000099007.1 ENSMUST00000099007.2 Gm14296 NM_001305133 uc029uja.1 uc029uja.2 uc029uja.3 uc029uja.4 uc029uja.5 Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc029uja.1 uc029uja.2 uc029uja.3 uc029uja.4 uc029uja.5 
ENSMUST00000099009.9 2210418O10Rik ENSMUST00000099009.9 RIKEN cDNA 2210418O10 gene, transcript variant 1 (from RefSeq NM_001305136.1) 2210418O10Rik A2ARL4 A2ARL4_MOUSE ENSMUST00000099009.1 ENSMUST00000099009.2 ENSMUST00000099009.3 ENSMUST00000099009.4 ENSMUST00000099009.5 ENSMUST00000099009.6 ENSMUST00000099009.7 ENSMUST00000099009.8 Gm14296 NM_001305136 uc008ofw.1 uc008ofw.2 uc008ofw.3 uc008ofw.4 uc008ofw.5 Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008ofw.1 uc008ofw.2 uc008ofw.3 uc008ofw.4 uc008ofw.5 
ENSMUST00000099060.2 Gcnt7 ENSMUST00000099060.2 glucosaminyl (N-acetyl) transferase family member 7 (from RefSeq NM_001039560.3) B2RSZ6 ENSMUST00000099060.1 GCNT7_MOUSE NM_001039560 Q3V174 Q3V3K7 uc008ocx.1 uc008ocx.2 Glycosyltransferase. Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3V3K7-1; Sequence=Displayed; Name=2; IsoId=Q3V3K7-2; Sequence=VSP_027537; Belongs to the glycosyltransferase 14 family. Golgi membrane molecular_function cellular_component Golgi apparatus protein glycosylation biological_process acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups uc008ocx.1 uc008ocx.2 
ENSMUST00000099071.5 Mocs3 ENSMUST00000099071.5 molybdenum cofactor synthesis 3 (from RefSeq NM_001160330.1) A2BDX3 ENSMUST00000099071.1 ENSMUST00000099071.2 ENSMUST00000099071.3 ENSMUST00000099071.4 MOCS3_MOUSE NM_001160330 Uba4 uc012cjs.1 uc012cjs.2 uc012cjs.3 Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 acting as a sulfur donor for thiocarboxylation reactions. Reaction=[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate; Xref=Rhea:RHEA:43616, Rhea:RHEA-COMP:12159, Rhea:RHEA-COMP:12202, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:90618, ChEBI:CHEBI:90778; EC=2.7.7.80; Evidence= Reaction=[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH- CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]; Xref=Rhea:RHEA:48612, Rhea:RHEA-COMP:12157, Rhea:RHEA-COMP:12158, Rhea:RHEA-COMP:12159, Rhea:RHEA-COMP:12160, ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:17499, ChEBI:CHEBI:29950, ChEBI:CHEBI:61963, ChEBI:CHEBI:90618, ChEBI:CHEBI:90619, ChEBI:CHEBI:456215; EC=2.8.1.11; Evidence= Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Cofactor biosynthesis; molybdopterin biosynthesis. Interacts with NFS1. Cytoplasm In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily. nucleotide binding tRNA wobble uridine modification tRNA wobble position uridine thiolation catalytic activity thiosulfate sulfurtransferase activity ATP binding cytoplasm cytosol Mo-molybdopterin cofactor biosynthetic process tRNA processing metabolic process small protein activating enzyme activity transferase activity nucleotidyltransferase activity sulfurtransferase activity enzyme active site formation via cysteine modification to L-cysteine persulfide protein urmylation tRNA thio-modification URM1 activating enzyme activity metal ion binding molybdopterin-synthase sulfurtransferase activity molybdopterin-synthase adenylyltransferase activity uc012cjs.1 uc012cjs.2 uc012cjs.3 
ENSMUST00000099073.3 Ripor3 ENSMUST00000099073.3 RIPOR family member 3, transcript variant 1 (from RefSeq NM_001080708.3) A1L3T7 ENSMUST00000099073.1 ENSMUST00000099073.2 Fam65c NM_001080708 RIPR3_MOUSE Ripor3 uc008oal.1 uc008oal.2 uc008oal.3 Belongs to the RIPOR family. molecular_function biological_process uc008oal.1 uc008oal.2 uc008oal.3 
ENSMUST00000099078.10 Arfgef2 ENSMUST00000099078.10 ADP ribosylation factor guanine nucleotide exchange factor 2 (from RefSeq NM_001085495.2) A2A5R2 Arfgep2 BIG2_MOUSE Big2 ENSMUST00000099078.1 ENSMUST00000099078.2 ENSMUST00000099078.3 ENSMUST00000099078.4 ENSMUST00000099078.5 ENSMUST00000099078.6 ENSMUST00000099078.7 ENSMUST00000099078.8 ENSMUST00000099078.9 NM_001085495 uc008nyr.1 uc008nyr.2 uc008nyr.3 uc008nyr.4 uc008nyr.5 Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways (By similarity). Inhibited by brefeldin A. Homodimer. Interacts with ARFGEF1/BIG1; both proteins are probably part of the same or very similar macromolecular complexes. Interacts with PRKAR1A, PRKAR2A, PRKAR1B, PRKAR2B, PPP1CC, PDE3A, TNFRSF1A, MYCBP and EXOC7. Interacts with GABRB1, GABRB2 and GABRB3 (By similarity). Cytoplasm Membrane Golgi apparatus Cytoplasm, perinuclear region Golgi apparatus, trans-Golgi network Endosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cell projection, dendrite Cytoplasmic vesicle Synapse Cytoplasm, cytoskeleton Note=Translocates from cytoplasm to membranes upon cAMP treatment. Localized in recycling endosomes (By similarity). In vitro phosphorylated by PKA reducing its GEF activity and dephosphorylated by phosphatase PP1. Golgi membrane receptor recycling guanyl-nucleotide exchange factor activity ARF guanyl-nucleotide exchange factor activity cytoplasm endosome Golgi apparatus trans-Golgi network microtubule organizing center cytosol cytoskeleton axonemal microtubule exocytosis Golgi to plasma membrane transport endosome organization endomembrane system organization protein transport membrane myosin binding cell junction dendrite cytoplasmic vesicle regulation of ARF protein signal transduction asymmetric synapse symmetric synapse positive regulation of tumor necrosis factor production protein kinase A regulatory subunit binding intracellular signal transduction cell projection dendritic spine synapse perinuclear region of cytoplasm GABA receptor binding recycling endosome uc008nyr.1 uc008nyr.2 uc008nyr.3 uc008nyr.4 uc008nyr.5 
ENSMUST00000099092.8 Slc12a5 ENSMUST00000099092.8 solute carrier family 12, member 5, transcript variant 3 (from RefSeq NM_020333.2) A2A5L0 ENSMUST00000099092.1 ENSMUST00000099092.2 ENSMUST00000099092.3 ENSMUST00000099092.4 ENSMUST00000099092.5 ENSMUST00000099092.6 ENSMUST00000099092.7 Kcc2 Kiaa1176 NM_020333 Q3UHQ2 Q7TQC9 Q80TI5 Q91V14 Q9Z0M7 S12A5_MOUSE uc008nwu.1 uc008nwu.2 uc008nwu.3 uc008nwu.4 Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (By similarity). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (By similarity). Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out); Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103; Evidence=; Inhibited following phosphorylation by OXSR1/OSR1 and STK39/SPAK: phosphorylation takes place downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4) in response to hyperosmotic stress and subsequent cell shrinkage. Homodimer (PubMed:33597714). Heteromultimer with other K-Cl cotransporters (By similarity). Interacts with AP2A1 (PubMed:18625303). Cell membrane ; Multi-pass membrane protein ll projection, dendrite Note=Detected on dendrites, but not on axons of spinal cord neurons and at GPHN-positive inhibitory synapses. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=KCC2a; IsoId=Q91V14-1; Sequence=Displayed; Name=2; Synonyms=KCC2b; IsoId=Q91V14-2; Sequence=VSP_029910; [Isoform 1]: Expressed in brainstem, spinal cord and olfactory bulb of 17 dpc embryos. Expressed in all parts of the brain and spinal cord in postnatal day 14 mice. [Isoform 2]: Expressed in brainstem and spinal cord of 17 dpc embryos. Expressed in all parts of the brain and spinal cord in postnatal day 14 mice. [Isoform 1]: Predominant isoform in 17 dpc brain. [Isoform 2]: Predominant isoform during postnatal development. Detected in the ventral horns of the spinal cord at 12.5 dpc, and throughout the spinal cord at birth. Phosphorylated at Thr-929 and Thr-1029 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), inhibiting the potassium-chloride cotransport activity. Death at birth due to severe motor deficits including respiratory failure. [Isoform 2]: Mice lacking isoform 2 die within 2 weeks after birth. Belongs to the SLC12A transporter family. Sequence=BAC65742.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding plasma membrane integral component of plasma membrane ion transport potassium ion transport chloride transport cellular ion homeostasis cell volume homeostasis hypotonic response chemical synaptic transmission learning ammonium transmembrane transporter activity chloride transmembrane transporter activity symporter activity cation:chloride symporter activity potassium:chloride symporter activity ammonium transport membrane integral component of membrane protein kinase binding transmembrane transporter activity dendrite cellular chloride ion homeostasis dendrite membrane multicellular organism growth thermosensory behavior response to drug cell projection neuronal cell body dendritic shaft perikaryon intracellular pH reduction chloride ion homeostasis potassium ion homeostasis transmembrane transport dendritic spine development chloride transmembrane transport potassium ion import across plasma membrane uc008nwu.1 uc008nwu.2 uc008nwu.3 uc008nwu.4 
ENSMUST00000099097.4 Spint3 ENSMUST00000099097.4 serine peptidase inhibitor, Kunitz type, 3 (from RefSeq NM_001177401.2) ENSMUST00000099097.1 ENSMUST00000099097.2 ENSMUST00000099097.3 NM_001177401 OTTMUSG00000016288 Q3UW09 Q3UW09_MOUSE Spint3 uc008nvf.1 uc008nvf.2 uc008nvf.3 uc008nvf.4 serine-type endopeptidase inhibitor activity extracellular space negative regulation of endopeptidase activity uc008nvf.1 uc008nvf.2 uc008nvf.3 uc008nvf.4 
ENSMUST00000099106.10 Mgst2 ENSMUST00000099106.10 microsomal glutathione S-transferase 2, transcript variant 1 (from RefSeq NM_174995.3) A2RST1 ENSMUST00000099106.1 ENSMUST00000099106.2 ENSMUST00000099106.3 ENSMUST00000099106.4 ENSMUST00000099106.5 ENSMUST00000099106.6 ENSMUST00000099106.7 ENSMUST00000099106.8 ENSMUST00000099106.9 Gst2 MGST2_MOUSE Mgst2 NM_174995 uc008ped.1 uc008ped.2 uc008ped.3 uc008ped.4 Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (By similarity). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251). Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Reaction=1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl- S-glutathione + chloride + H(+); Xref=Rhea:RHEA:51220, ChEBI:CHEBI:15378, ChEBI:CHEBI:17996, ChEBI:CHEBI:34718, ChEBI:CHEBI:57925, ChEBI:CHEBI:133977; EC=2.5.1.18; Evidence=; Reaction=leukotriene C4 = glutathione + leukotriene A4; Xref=Rhea:RHEA:17617, ChEBI:CHEBI:57463, ChEBI:CHEBI:57925, ChEBI:CHEBI:57973; EC=4.4.1.20; Evidence=; Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48620, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90632; Evidence=; Each monomer binds on GSH molecule but only one subunit is catalytically active. Homotrimer. Endoplasmic reticulum membrane ; Multi-pass membrane protein Microsome membrane ; Multi-pass membrane protein Deficient mice display resistance to induced ER stress with reduced cell death and mortality. glutathione transferase activity leukotriene-C4 synthase activity glutathione peroxidase activity nuclear envelope cytoplasm endoplasmic reticulum plasma membrane lipid metabolic process leukotriene metabolic process glutathione biosynthetic process enzyme activator activity membrane integral component of membrane transferase activity leukotriene biosynthetic process positive regulation of catalytic activity intracellular membrane-bounded organelle membrane lipid catabolic process cellular oxidant detoxification uc008ped.1 uc008ped.2 uc008ped.3 uc008ped.4 
ENSMUST00000099112.4 Itga7 ENSMUST00000099112.4 integrin alpha 7, transcript variant 1 (from RefSeq NM_008398.3) ENSMUST00000099112.1 ENSMUST00000099112.2 ENSMUST00000099112.3 G3X9Q1 G3X9Q1_MOUSE Itga7 NM_008398 uc007hpa.1 uc007hpa.2 uc007hpa.3 uc007hpa.4 This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded transmembrane protein is the alpha subunit that forms a noncovalent heterodimer with the beta subunit to form the functional integrin receptor that binds to laminin. Mice lacking the encoded protein exhibit symptoms of progressive muscular dystrophy, impaired axonal regeneration and cerebral vascular defects. [provided by RefSeq, Aug 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## Membrane ingle-pass type I membrane protein Belongs to the integrin alpha chain family. cell adhesion integrin-mediated signaling pathway integrin complex membrane integral component of membrane heterotypic cell-cell adhesion endodermal cell differentiation uc007hpa.1 uc007hpa.2 uc007hpa.3 uc007hpa.4 
ENSMUST00000099123.5 Fundc2b ENSMUST00000099123.5 FUN14 domain containing 2B (from RefSeq NM_028494.3) 1700034I23Rik ENSMUST00000099123.1 ENSMUST00000099123.2 ENSMUST00000099123.3 ENSMUST00000099123.4 Fundc2b NM_028494 Q9D9Q3 Q9D9Q3_MOUSE uc008pbx.1 uc008pbx.2 uc008pbx.3 Mitochondrion outer membrane ; Multi-pass membrane protein Belongs to the FUN14 family. mitophagy molecular_function mitochondrion integral component of mitochondrial outer membrane uc008pbx.1 uc008pbx.2 uc008pbx.3 
ENSMUST00000099126.5 Mafb ENSMUST00000099126.5 MAF bZIP transcription factor B (from RefSeq NM_010658.3) ENSMUST00000099126.1 ENSMUST00000099126.2 ENSMUST00000099126.3 ENSMUST00000099126.4 Krml MAFB_MOUSE Maf1 NM_010658 P54841 Q3U3C8 Q3UPT9 uc008nqw.1 uc008nqw.2 uc008nqw.3 uc008nqw.4 Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (PubMed:11823429). Homodimer or heterodimer with other bHLH-Zip transcription factors. Forms homodimers and heterodimers with FOS, FOSB and FOSL2, but not with JUN proteins (JUN, JUNB and JUND). Interacts with the intracellular cytoplasmic domain of LRP1 (LRPICD); the interaction results in a moderate reduction of MAFB transcriptional potential (By similarity). Binds DNA as a homodimer or a heterodimer. Interacts with PAX6; the interaction is direct. Interacts with ETS1 and LRP1. P54841; P01101: Fos; NbExp=4; IntAct=EBI-16093217, EBI-4288185; Nucleus Expressed in pancreatic alpha-cells (glucagon- positive cells), in podocytes of the kidney and macrophages (at protein level). Most abundant in kidney, gut, lung and brain. Expressed in pancreatic alpha-cells at 10.5 dpc (PubMed:17901057). Expressed in insulin and glucagon islet progenitor cells at 12 dpc onwards (at protein level) (PubMed:16443760). Detectable at 8.0 dpc (one somite) as a band in the caudal hindbrain and by 8.5 dpc (six to eight somites) as a sharp rostral edge coincident with the rhombomeres (r) 4 and 5 boundary and a diffuse caudal edge located midway through r6 (PubMed:8001130). Expressed in the lens epithelial cells at 10.5 to 14.5 dpc (PubMed:10383433). Expressed in the cochlear nucleus at 15.5 dpc (PubMed:17977745). The leucine-zipper domain is involved in the interaction with LRPICD. Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors. Mice show a defect in frequency of respiratory rhythm with a fatal apnea at birth due to lack of neurons from the preBoetC region. They displayed renal dysgenesis with abnormal podocyte differentiation as well as tubular apoptosis. They show altered actin- dependent macrophage morphology. They show a reduced number of cells expressing insulin and glucagon. Embryos also lack the abducens nerve which normaly innervates the lateral rectus muscle that is involved in eye movement (PubMed:27181683). Belongs to the bZIP family. Maf subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter segment specification respiratory gaseous exchange transcription factor binding rhombomere 5 development rhombomere 6 development abducens nerve formation T cell differentiation in thymus brain segmentation inner ear morphogenesis protein homodimerization activity sequence-specific DNA binding negative regulation of erythrocyte differentiation negative regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity thymus development sequence-specific double-stranded DNA binding uc008nqw.1 uc008nqw.2 uc008nqw.3 uc008nqw.4 
ENSMUST00000099127.3 Gm826 ENSMUST00000099127.3 predicted gene 826, transcript variant 1 (from RefSeq NR_184641.1) ENSMUST00000099127.1 ENSMUST00000099127.2 Gm826 NR_184641 Q3UQ74 Q3UQ74_MOUSE uc008nqv.1 uc008nqv.2 uc008nqv.3 molecular_function cellular_component biological_process uc008nqv.1 uc008nqv.2 uc008nqv.3 
ENSMUST00000099130.9 Nudt6 ENSMUST00000099130.9 nudix hydrolase 6, transcript variant 2 (from RefSeq NM_153561.3) A0A0R4J176 A0A0R4J176_MOUSE ENSMUST00000099130.1 ENSMUST00000099130.2 ENSMUST00000099130.3 ENSMUST00000099130.4 ENSMUST00000099130.5 ENSMUST00000099130.6 ENSMUST00000099130.7 ENSMUST00000099130.8 NM_153561 Nudt6 uc008par.1 uc008par.2 uc008par.3 uc008par.4 May contribute to the regulation of cell proliferation. Monomer and homodimer. Cytoplasm Nucleus Mitochondrion Belongs to the Nudix hydrolase family. hydrolase activity uc008par.1 uc008par.2 uc008par.3 uc008par.4 
ENSMUST00000099131.11 Smarcc2 ENSMUST00000099131.11 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2, transcript variant 4 (from RefSeq NM_001372395.1) ENSMUST00000099131.1 ENSMUST00000099131.10 ENSMUST00000099131.2 ENSMUST00000099131.3 ENSMUST00000099131.4 ENSMUST00000099131.5 ENSMUST00000099131.6 ENSMUST00000099131.7 ENSMUST00000099131.8 ENSMUST00000099131.9 NM_001372395 Q3UID0 Q3UID0_MOUSE Smarcc2 uc007hmy.1 uc007hmy.2 uc007hmy.3 uc007hmy.4 DNA binding nucleus SWI/SNF complex npBAF complex nBAF complex uc007hmy.1 uc007hmy.2 uc007hmy.3 uc007hmy.4 
ENSMUST00000099133.11 Arhgap40 ENSMUST00000099133.11 Rho GTPase activating protein 40 (from RefSeq NM_001145015.2) A2ACC5 Arhgap40 E9Q6X9 ENSMUST00000099133.1 ENSMUST00000099133.10 ENSMUST00000099133.2 ENSMUST00000099133.3 ENSMUST00000099133.4 ENSMUST00000099133.5 ENSMUST00000099133.6 ENSMUST00000099133.7 ENSMUST00000099133.8 ENSMUST00000099133.9 NM_001145015 RHG40_MOUSE uc290cdy.1 uc290cdy.2 uc290cdy.3 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Sequence=CAM23059.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; GTPase activator activity cytoplasm signal transduction regulation of actin filament polymerization regulation of actin cytoskeleton organization positive regulation of GTPase activity regulation of small GTPase mediated signal transduction uc290cdy.1 uc290cdy.2 uc290cdy.3 
ENSMUST00000099145.6 Dlgap4 ENSMUST00000099145.6 DLG associated protein 4, transcript variant 2 (from RefSeq NM_001042487.1) B1AZP2 B1AZP3 B7ZNS1 DLGP4_MOUSE ENSMUST00000099145.1 ENSMUST00000099145.2 ENSMUST00000099145.3 ENSMUST00000099145.4 ENSMUST00000099145.5 Kiaa0964 NM_001042487 Q3KQQ8 Q6PD44 Q6XBF1 Q80TN3 Q8R3U9 Sapap4 uc008nnv.1 uc008nnv.2 uc008nnv.3 This gene encodes a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. The encoded protein may play a role in synapse organization and neuronal signalling. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Mar 2013]. May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD- 95/SAP90 at the plasma membrane (By similarity). Interacts with DLG1 and DLG4/PSD-95. Membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=B1AZP2-1; Sequence=Displayed; Name=2; IsoId=B1AZP2-2; Sequence=VSP_034909; Name=3; IsoId=B1AZP2-3; Sequence=VSP_034907, VSP_034908; Belongs to the SAPAP family. Sequence=BAC65690.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; protein binding plasma membrane membrane protein domain specific binding signaling dendrite neuromuscular junction neuronal cell body synapse glutamatergic synapse cholinergic synapse postsynaptic specialization uc008nnv.1 uc008nnv.2 uc008nnv.3 
ENSMUST00000099149.10 Nnt ENSMUST00000099149.10 nicotinamide nucleotide transhydrogenase, transcript variant 2 (from RefSeq NM_001308506.1) ENSMUST00000099149.1 ENSMUST00000099149.2 ENSMUST00000099149.3 ENSMUST00000099149.4 ENSMUST00000099149.5 ENSMUST00000099149.6 ENSMUST00000099149.7 ENSMUST00000099149.8 ENSMUST00000099149.9 NM_001308506 Nnt Q8BGK0 Q8BGK0_MOUSE uc057kqy.1 uc057kqy.2 uc057kqy.3 Reaction=H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+); Xref=Rhea:RHEA:47992, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349; EC=7.1.1.1; Evidence=; In the N-terminal section; belongs to the AlaDH/PNT family. membrane integral component of membrane oxidoreductase activity oxidation-reduction process uc057kqy.1 uc057kqy.2 uc057kqy.3 
ENSMUST00000099151.6 Sox2 ENSMUST00000099151.6 SRY (sex determining region Y)-box 2 (from RefSeq NM_011443.4) ENSMUST00000099151.1 ENSMUST00000099151.2 ENSMUST00000099151.3 ENSMUST00000099151.4 ENSMUST00000099151.5 NM_011443 Q60I23 Q60I23_MOUSE Sox2 uc008oxu.1 uc008oxu.2 uc008oxu.3 uc008oxu.4 uc008oxu.5 This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in a similar gene in human have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (Sox2ot). [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Q60I23; Q6PDQ2: Chd4; NbExp=3; IntAct=EBI-6120118, EBI-3043852; Q60I23; A2AJK6: Chd7; NbExp=6; IntAct=EBI-6120118, EBI-6122905; transcription regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding osteoblast differentiation eye development endodermal cell fate specification DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated cell cycle arrest response to wounding regulation of gene expression pituitary gland development adenohypophysis development positive regulation of cell-cell adhesion forebrain development somatic stem cell population maintenance miRNA binding tissue regeneration regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter inner ear development negative regulation of epithelial cell proliferation response to growth factor negative regulation of canonical Wnt signaling pathway uc008oxu.1 uc008oxu.2 uc008oxu.3 uc008oxu.4 uc008oxu.5 
ENSMUST00000099162.3 Gm10735 ENSMUST00000099162.3 Gm10735 (from geneSymbol) ENSMUST00000099162.1 ENSMUST00000099162.2 uc056yvh.1 uc056yvh.2 uc056yvh.1 uc056yvh.2 
ENSMUST00000099166.10 Ddx4 ENSMUST00000099166.10 DEAD box helicase 4, transcript variant 1 (from RefSeq NM_001145885.1) Ddx4 ENSMUST00000099166.1 ENSMUST00000099166.2 ENSMUST00000099166.3 ENSMUST00000099166.4 ENSMUST00000099166.5 ENSMUST00000099166.6 ENSMUST00000099166.7 ENSMUST00000099166.8 ENSMUST00000099166.9 NM_001145885 Q3V086 Q3V086_MOUSE uc007rwn.1 uc007rwn.2 uc007rwn.3 uc007rwn.4 Belongs to the DEAD box helicase family. nucleotide binding nucleic acid binding RNA helicase activity helicase activity ATP binding cytoplasm hydrolase activity flagellated sperm motility uc007rwn.1 uc007rwn.2 uc007rwn.3 uc007rwn.4 
ENSMUST00000099170.2 Gm1527 ENSMUST00000099170.2 predicted gene 1527 (from RefSeq NM_001033479.5) ENSMUST00000099170.1 Gm1527 NM_001033479 Q3V0P3 Q3V0P3_MOUSE uc008ouh.1 uc008ouh.2 GTPase activator activity cellular_component signal transduction membrane integral component of membrane positive regulation of GTPase activity uc008ouh.1 uc008ouh.2 
ENSMUST00000099172.5 Kif5a ENSMUST00000099172.5 kinesin family member 5A, transcript variant 1 (from RefSeq NM_001039000.4) ENSMUST00000099172.1 ENSMUST00000099172.2 ENSMUST00000099172.3 ENSMUST00000099172.4 KIF5A_MOUSE Kiaa4086 Kif5 NM_001039000 Nkhc1 P33175 Q5DTP1 Q6PDY7 Q9Z2F9 uc007his.1 uc007his.2 uc007his.3 uc007his.4 Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (PubMed:12682084). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons (PubMed:21976701). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 (PubMed:11986669). Interacts with FMR1 (via C- terminus); this interaction is increased in a mGluR-dependent manner (PubMed:18539120). Interacts with BORCS5 (By similarity). Interacts with ZFYVE27 (PubMed:21976701, PubMed:24251978). Interacts with VAPA, VAPB, SURF4, RAB11A (GDP-bound form), RAB11B (GDP-bound form) and RTN3 in a ZFYVE27-dependent manner (PubMed:21976701). Interacts with BICD2 (By similarity). Interacts with DTNB (PubMed:14600269). P33175; O08788: Dctn1; NbExp=2; IntAct=EBI-349710, EBI-776180; P33175; O70585: Dtnb; NbExp=4; IntAct=EBI-349710, EBI-349714; P33175; Q96NW4: ANKRD27; Xeno; NbExp=2; IntAct=EBI-349710, EBI-6125599; Cytoplasm, perinuclear region Cytoplasm, cytoskeleton Perikaryon Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region. Composed of three structural domains: a large globular N- terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles. Death shortly after birth. Neuron-specific deletion within the first 3 weeks after birth is lethal in 75% of animals. Surviving animals show accumulation of neurofilament proteins in neuronal soma, age-dependent sensory neuron degeneration, loss of large caliber axons, and hind limb paralysis with a stronger effect on sensory neurons compared with motor neurons. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily. Sequence=BAD90503.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding P-body microtubule motor activity protein binding ATP binding cytoplasm cytosol cytoskeleton kinesin complex microtubule microtubule-based movement axon guidance microtubule binding ATP-dependent microtubule motor activity, plus-end-directed vesicle-mediated transport ATPase activity kinesin binding axon dendrite dendrite cytoplasm ciliary rootlet neuron projection neuronal cell body perikaryon macromolecular complex binding perinuclear region of cytoplasm synaptic vesicle transport central region of growth cone scaffold protein binding apical dendrite anterograde dendritic transport of neurotransmitter receptor complex anterograde axonal protein transport axon cytoplasm retrograde neuronal dense core vesicle transport uc007his.1 uc007his.2 uc007his.3 uc007his.4 
ENSMUST00000099173.11 Eif2s2 ENSMUST00000099173.11 eukaryotic translation initiation factor 2 subunit 2 beta (from RefSeq NM_026030.2) ENSMUST00000099173.1 ENSMUST00000099173.10 ENSMUST00000099173.2 ENSMUST00000099173.3 ENSMUST00000099173.4 ENSMUST00000099173.5 ENSMUST00000099173.6 ENSMUST00000099173.7 ENSMUST00000099173.8 ENSMUST00000099173.9 IF2B_MOUSE NM_026030 Q99L45 Q9CSH6 Q9CT12 uc008njw.1 uc008njw.2 uc008njw.3 Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B. Eukaryotic translation initiation factor 2 eIF2 is a heterotrimeric complex composed of an alpha (EIF2S1), a beta (EIF2S2) and a gamma (EIF2S3) chain (PubMed:16931514). eIF2 is member of the 43S pre-initiation complex (43S PIC). eIF2 forms a complex with at least CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (PubMed:16931514). Interacts with BZW2/5MP1 (By similarity). Interacts with EIF5 (By similarity). Cytoplasm, cytosol Belongs to the eIF-2-beta/eIF-5 family. Sequence=BAB28490.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; in utero embryonic development formation of translation preinitiation complex formation of cytoplasmic translation initiation complex male germ cell proliferation mRNA binding translation initiation factor activity protein binding cytoplasm eukaryotic translation initiation factor 2 complex translation translational initiation male gonad development translation initiation factor binding metal ion binding uc008njw.1 uc008njw.2 uc008njw.3 
ENSMUST00000099194.4 Tspyl3 ENSMUST00000099194.4 TSPY-like 3 (from RefSeq NM_198617.2) ENSMUST00000099194.1 ENSMUST00000099194.2 ENSMUST00000099194.3 NM_198617 Q3UYP3 Q3UYP3_MOUSE Tspyl3 uc008nhi.1 uc008nhi.2 uc008nhi.3 Belongs to the nucleosome assembly protein (NAP) family. molecular_function cellular_component nucleus nucleosome assembly biological_process uc008nhi.1 uc008nhi.2 uc008nhi.3 
ENSMUST00000099195.10 Pde7a ENSMUST00000099195.10 phosphodiesterase 7A, transcript variant 2 (from RefSeq NM_001122759.2) ENSMUST00000099195.1 ENSMUST00000099195.2 ENSMUST00000099195.3 ENSMUST00000099195.4 ENSMUST00000099195.5 ENSMUST00000099195.6 ENSMUST00000099195.7 ENSMUST00000099195.8 ENSMUST00000099195.9 NM_001122759 Pde7a Q3U3Y7 Q3U3Y7_MOUSE uc008oru.1 uc008oru.2 uc008oru.3 uc008oru.4 Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Belongs to the cyclic nucleotide phosphodiesterase family. 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity signal transduction phosphoric diester hydrolase activity hydrolase activity metal ion binding uc008oru.1 uc008oru.2 uc008oru.3 uc008oru.4 
ENSMUST00000099197.9 Ttll9 ENSMUST00000099197.9 tubulin tyrosine ligase-like family, member 9, transcript variant 4 (from RefSeq NM_001355719.1) A2APC3 A2APC4 A2APC5 A2APC6 ENSMUST00000099197.1 ENSMUST00000099197.2 ENSMUST00000099197.3 ENSMUST00000099197.4 ENSMUST00000099197.5 ENSMUST00000099197.6 ENSMUST00000099197.7 ENSMUST00000099197.8 NM_001355719 Q9D570 TTLL9_MOUSE Ttll9 uc008ngx.1 uc008ngx.2 uc008ngx.3 Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins (PubMed:27257088). Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity (Probable). Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern (PubMed:27257088). Reaction=(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60148, Rhea:RHEA-COMP:15519, Rhea:RHEA-COMP:15675, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143623, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60149; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, flagellum axoneme Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2APC3-1; Sequence=Displayed; Name=2; IsoId=A2APC3-2; Sequence=VSP_032261; Highly expressed in brain and testis (PubMed:17499049). Expressed in heart, kidney and lung (PubMed:17499049). In the brain, expressed in ependymal cilia, cortex, corpus callosum and striatum (PubMed:23897886). In the testis, specifically expressed in the seminiferous tubules (PubMed:27257088). Gln-155 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate- chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation. Males are infertile due to a reduction in sperm count and defective sperm motility. Sperm axonemes have shortened microtubule doublet 7 and reduced tubulin polyglutamylation, in particular of doublet 5. Reduced sperm motility is caused by frequent stalls of flagella due to defective switching in the bending direction. Belongs to the tubulin--tyrosine ligase family. Sequence=CAM23684.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM23685.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding molecular_function ATP binding cellular_component cytoplasm cytoskeleton microtubule cilium cellular protein modification process biological_process ligase activity cell projection uc008ngx.1 uc008ngx.2 uc008ngx.3 
ENSMUST00000099200.3 Foxs1 ENSMUST00000099200.3 forkhead box S1 (from RefSeq NM_010226.2) ENSMUST00000099200.1 ENSMUST00000099200.2 FOXS1_MOUSE Fkh3 Fkhl18 Freac10 NM_010226 Q61574 Q8C5N7 uc008ngt.1 uc008ngt.2 Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature. Nucleus Expressed in the testis in Sertoli and periendothelial cells at 14 dpc. Accumulation of blood in the central part of the fetal testis. Increased ectopic apoptosis in periendothelial cells of the testis. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding blood vessel development DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter anatomical structure morphogenesis cell differentiation positive regulation of multicellular organism growth negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding negative regulation of transcription, DNA-templated neuromuscular process controlling balance uc008ngt.1 uc008ngt.2 
ENSMUST00000099203.2 Defb25 ENSMUST00000099203.2 defensin beta 25 (from RefSeq NM_001039122.2) DFB25_MOUSE ENSMUST00000099203.1 NM_001039122 Q30KN8 uc008nfv.1 uc008nfv.2 Has antibacterial activity. Secreted Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium innate immune response uc008nfv.1 uc008nfv.2 
ENSMUST00000099205.2 Defb26 ENSMUST00000099205.2 defensin beta 26 (from RefSeq NM_001039120.3) Defb26 EG654457 ENSMUST00000099205.1 NM_001039120 Q30KN7 Q30KN7_MOUSE uc008nfo.1 uc008nfo.2 uc008nfo.3 uc008nfo.4 Has antibacterial activity. Secreted Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium innate immune response uc008nfo.1 uc008nfo.2 uc008nfo.3 uc008nfo.4 
ENSMUST00000099206.3 Defb23 ENSMUST00000099206.3 defensin beta 23 (from RefSeq NM_001037933.3) Defb23 EG629114 ENSMUST00000099206.1 ENSMUST00000099206.2 NM_001037933 Q30KP0 Q30KP0_MOUSE uc008nfl.1 uc008nfl.2 uc008nfl.3 Has antibacterial activity. Secreted Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium innate immune response uc008nfl.1 uc008nfl.2 uc008nfl.3 
ENSMUST00000099207.5 Zcchc3 ENSMUST00000099207.5 zinc finger, CCHC domain containing 3 (from RefSeq NM_175126.5) ENSMUST00000099207.1 ENSMUST00000099207.2 ENSMUST00000099207.3 ENSMUST00000099207.4 NM_175126 Q8BPK2 ZCHC3_MOUSE Zcchc3 uc008nfj.1 uc008nfj.2 uc008nfj.3 uc008nfj.4 Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (By similarity). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (By similarity). Promotes sensing of viral RNA by RIG-I-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 (By similarity). Interacts with CGAS (By similarity). Interacts with RIGI (By similarity). Interacts with IFIH1/MDA5 (By similarity). Cytoplasm Mice were born at the Mendelian ratio and do not show defects in development and immune cell differentiation (PubMed:30193849). Mice are however more susceptible to DNA and RNA virus infection (PubMed:30193849, PubMed:30135424). activation of innate immune response immune system process nucleic acid binding DNA binding double-stranded DNA binding RNA binding cytoplasm zinc ion binding detection of virus positive regulation of type I interferon production innate immune response metal ion binding defense response to virus cellular response to exogenous dsRNA positive regulation of RIG-I signaling pathway uc008nfj.1 uc008nfj.2 uc008nfj.3 uc008nfj.4 
ENSMUST00000099224.10 Csnk2a1 ENSMUST00000099224.10 casein kinase 2, alpha 1 polypeptide, transcript variant 1 (from RefSeq NM_007788.4) CSK21_MOUSE Ckiia ENSMUST00000099224.1 ENSMUST00000099224.2 ENSMUST00000099224.3 ENSMUST00000099224.4 ENSMUST00000099224.5 ENSMUST00000099224.6 ENSMUST00000099224.7 ENSMUST00000099224.8 ENSMUST00000099224.9 NM_007788 Q60737 Q8R0X4 uc008nfa.1 uc008nfa.2 uc008nfa.3 uc008nfa.4 uc008nfa.5 Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC060742.1, AK146032.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (By similarity). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (By similarity). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (By similarity). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (By similarity). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (By similarity). Can also negatively regulate apoptosis (PubMed:18467326). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:18467326). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:18467326). Phosphorylates YY1, protecting YY1 from cleavage by CASP7 during apoptosis (By similarity). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (By similarity). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB (By similarity). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (By similarity). Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (By similarity). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:10806215). Acts as an ectokinase that phosphorylates several extracellular proteins (By similarity). Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (By similarity). Plays an important role in the circadian clock function by phosphorylating BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates FMR1, promoting FMR1-dependent formation of a membraneless compartment (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization (By similarity). Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha'/2 beta or 1 alpha/1 alpha'/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation (By similarity). Interacts with RNPS1 (By similarity). Interacts with SNAI1 (PubMed:19923321). Interacts with PML and CCAR2 (By similarity). Q60737; Q9WTL8: Bmal1; NbExp=5; IntAct=EBI-771698, EBI-644534; Q60737; P67871: Csnk2b; NbExp=5; IntAct=EBI-771698, EBI-348179; Nucleus Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase. Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its regulation by forming binding sites for interacting proteins and/or targeting it to different compartments (By similarity). Embryonic lethality at 10.5 dpc. Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. nucleotide binding chromatin protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol plasma membrane protein kinase CK2 complex protein phosphorylation apoptotic process cell cycle beta-catenin binding positive regulation of cell proliferation Wnt signaling pathway kinase activity phosphorylation Sin3 complex NuRD complex transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation protein phosphatase regulator activity positive regulation of Wnt signaling pathway positive regulation of cell growth identical protein binding ribonucleoprotein complex binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of phosphoprotein phosphatase activity positive regulation of protein catabolic process protein autophosphorylation protein N-terminus binding rhythmic process regulation of cell cycle regulation of protein localization to plasma membrane negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process PcG protein complex uc008nfa.1 uc008nfa.2 uc008nfa.3 uc008nfa.4 uc008nfa.5 
ENSMUST00000099241.4 Ccl28 ENSMUST00000099241.4 C-C motif chemokine ligand 28 (from RefSeq NM_020279.3) CCL28_MOUSE ENSMUST00000099241.1 ENSMUST00000099241.2 ENSMUST00000099241.3 NM_020279 Q9JIL2 Scya28 uc007sal.1 uc007sal.2 uc007sal.3 Chemotactic for resting CD4, CD8 T-cells and eosinophils (By similarity). Binds to CCR10 and induces calcium mobilization in a dose- dependent manner. Secreted Mainly expressed in testis, epithelial cells of normal colon, kidney, Peyer patches, lymph nodes. Also found in lower levels in brain, spleen and lung. Belongs to the intercrine beta (chemokine CC) family. positive regulation of cell-matrix adhesion cytokine activity extracellular region extracellular space cell chemotaxis immune response signal transduction positive regulation of cytosolic calcium ion concentration chemokine activity killing of cells of other organism cytolysis in other organism cell chemotaxis negative regulation of leukocyte tethering or rolling secretory granule uc007sal.1 uc007sal.2 uc007sal.3 
ENSMUST00000099245.2 ENSMUSG00000074720 ENSMUST00000099245.2 ENSMUSG00000074720 (from geneSymbol) ENSMUST00000099245.1 uc291cew.1 uc291cew.2 uc291cew.1 uc291cew.2 
ENSMUST00000099265.3 Fndc10 ENSMUST00000099265.3 fibronectin type III domain containing 10 (from RefSeq NM_178699.5) A2A9Q0 ENSMUST00000099265.1 ENSMUST00000099265.2 FND10_MOUSE NM_178699 Q8BXK6 uc008wei.1 uc008wei.2 uc008wei.3 uc008wei.4 uc008wei.5 Membrane ; Single-pass type I membrane protein Sequence=BAC32775.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008wei.1 uc008wei.2 uc008wei.3 uc008wei.4 uc008wei.5 
ENSMUST00000099266.3 Gm10750 ENSMUST00000099266.3 Gm10750 (from geneSymbol) AK133133 ENSMUST00000099266.1 ENSMUST00000099266.2 uc290bel.1 uc290bel.2 uc290bel.1 uc290bel.2 
ENSMUST00000099269.4 Cd93 ENSMUST00000099269.4 CD93 antigen (from RefSeq NM_010740.3) A2AVY5 Aa4 C1QR1_MOUSE C1qr1 C1qrp ENSMUST00000099269.1 ENSMUST00000099269.2 ENSMUST00000099269.3 Ly68 NM_010740 O89103 Q3U2X0 uc008mte.1 uc008mte.2 uc008mte.3 Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. Marker for early multipotent hematopoietic precursor cells. May play a role in cell-cell interactions during hematopoietic and vascular development. Interacts with C1QBP; the association may represent a cell surface C1q receptor. Membrane; Single-pass type I membrane protein. Expressed in lung, heart and bone marrow. Expressed at lower level in ovary, whole embryo and fetal liver. Not detected in brain, adult liver or thymus. Highly expressed in peritoneal cavity and bone marrow macrophages. Not detected in epithelial cells. First detectable in day 9 embryos, in the endocardium and vascular endothelium in the anterior part of the embryo. Expression in endothelial cells, initially restricted to aorta, omphalomesenteric and umbilical arteries, later extends to subcardinal veins, intersomitic arteries and perineural vessels. On day 10, detectable in the entire embryo. N- and O-glycosylated. complement component C1q binding calcium ion binding plasma membrane cell adhesion cell surface membrane integral component of membrane carbohydrate binding cytoplasmic vesicle transforming growth factor beta binding cell-cell adhesion uc008mte.1 uc008mte.2 uc008mte.3 
ENSMUST00000099270.5 Thbd ENSMUST00000099270.5 thrombomodulin (from RefSeq NM_009378.3) ENSMUST00000099270.1 ENSMUST00000099270.2 ENSMUST00000099270.3 ENSMUST00000099270.4 NM_009378 Q543W3 Q543W3_MOUSE Thbd uc008mtd.1 uc008mtd.2 uc008mtd.3 uc008mtd.4 Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Interacts with ITGAL, ITGAM and ITGB2. Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. transmembrane signaling receptor activity calcium ion binding extracellular space vacuolar membrane plasma membrane integral component of plasma membrane cell surface response to X-ray membrane integral component of membrane apicolateral plasma membrane negative regulation of blood coagulation response to lipopolysaccharide response to cAMP uc008mtd.1 uc008mtd.2 uc008mtd.3 uc008mtd.4 
ENSMUST00000099274.4 Pdzd8 ENSMUST00000099274.4 PDZ domain containing 8 (from RefSeq NM_001033222.3) B9EJ80 ENSMUST00000099274.1 ENSMUST00000099274.2 ENSMUST00000099274.3 NM_001033222 PDZD8_MOUSE Pdzd8 Q3UMB1 uc008ibj.1 uc008ibj.2 uc008ibj.3 uc008ibj.4 Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Interacts with MSN. Endoplasmic reticulum membrane ; Single-pass membrane protein Note=Localizes at mitochondria-endoplasmic reticulum contact sites. The SMP-LTD domain is a barrel-like domain that binds phospholipids. Null animals show poor overall growth and reduced total brain volume, although the relative volume of certain regions is increased. Mutant mice demonstrate impaired hippocampal-dependent spatial memory, increased spontaneous repetitive stereotypic motor movements and decreased anxiety-like behavior compared to controls. molecular_function mitochondrion endoplasmic reticulum endoplasmic reticulum membrane lipid transport cytoskeleton organization lipid binding membrane integral component of membrane regulation of cell morphogenesis intracellular signal transduction ER-mitochondrion membrane contact site metal ion binding mitochondrial calcium ion homeostasis mitochondrion-ER tethering uc008ibj.1 uc008ibj.2 uc008ibj.3 uc008ibj.4 
ENSMUST00000099276.4 Atxn7l3b ENSMUST00000099276.4 ataxin 7-like 3B (from RefSeq NM_001033474.2) A7L3B_MOUSE ENSMUST00000099276.1 ENSMUST00000099276.2 ENSMUST00000099276.3 NM_001033474 Q3UD01 uc007has.1 uc007has.2 uc007has.3 By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3. Interacts strongly with ENY2. Interacts weakly with USP22. Cytoplasm Encoded by an expressed retrotransposed copy of the Atxn7l3 locus that emerged prior to the speciation event separating primates and rodents. Belongs to the SGF11 family. cytoplasm regulation of gene expression uc007has.1 uc007has.2 uc007has.3 
ENSMUST00000099278.9 Kiz ENSMUST00000099278.9 kizuna centrosomal protein (from RefSeq NM_001033298.4) A2AUS7 B2RX19 ENSMUST00000099278.1 ENSMUST00000099278.2 ENSMUST00000099278.3 ENSMUST00000099278.4 ENSMUST00000099278.5 ENSMUST00000099278.6 ENSMUST00000099278.7 ENSMUST00000099278.8 Gm114 KIZ_MOUSE NM_001033298 Plk1s1 Q3UXL4 uc008mso.1 uc008mso.2 uc008mso.3 Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. Interacts with AKAP9, CEP72, ODF2, PCNT and TUBGCP2. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body Note=Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome- surrounding area in a microtubule-independent and dependent manner, respectively. Phosphorylation at Thr-391 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization. Belongs to the kizuna family. Sequence=CAM27275.1; Type=Erroneous gene model prediction; Evidence=; cytoplasm centrosome microtubule organizing center cytoskeleton spindle organization protein kinase binding cell projection uc008mso.1 uc008mso.2 uc008mso.3 
ENSMUST00000099295.6 Poc5 ENSMUST00000099295.6 POC5 centriolar protein (from RefSeq NM_026173.3) ENSMUST00000099295.1 ENSMUST00000099295.2 ENSMUST00000099295.3 ENSMUST00000099295.4 ENSMUST00000099295.5 NM_026173 POC5_MOUSE Q8C299 Q8CI36 Q9CZ74 Q9DBS8 uc007rmw.1 uc007rmw.2 uc007rmw.3 uc007rmw.4 Essential for the assembly of the distal half of centrioles, required for centriole elongation. Interacts with CETN2 and CETN3. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localized to the distal portion of centrioles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DBS8-1; Sequence=Displayed; Name=2; IsoId=Q9DBS8-2; Sequence=VSP_024101, VSP_024102; Hyperphosphorylated during recruitment to procentrioles in G2/M phase. Belongs to the POC5 family. Sequence=BAB28553.1; Type=Frameshift; Evidence=; protein binding nucleus nucleoplasm cytoplasm centrosome centriole cytosol cytoskeleton cell cycle biological_process uc007rmw.1 uc007rmw.2 uc007rmw.3 uc007rmw.4 
ENSMUST00000099309.6 Bhmt ENSMUST00000099309.6 betaine-homocysteine methyltransferase (from RefSeq NM_016668.3) BHMT1_MOUSE ENSMUST00000099309.1 ENSMUST00000099309.2 ENSMUST00000099309.3 ENSMUST00000099309.4 ENSMUST00000099309.5 NM_016668 O35490 Q3UEM1 Q3UL72 Q561N0 uc007rli.1 uc007rli.2 uc007rli.3 Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. Reaction=glycine betaine + L-homocysteine = L-methionine + N,N- dimethylglycine; Xref=Rhea:RHEA:22336, ChEBI:CHEBI:17750, ChEBI:CHEBI:57844, ChEBI:CHEBI:58199, ChEBI:CHEBI:58251; EC=2.1.1.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22337; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. Homotetramer. Cytoplasm, cytosol Nucleus Note=Predominantly localized in the cytoplasm with a small fraction detected in the nucleus. Translocates into the nucleus upon oxidative stress. cytoplasm cytosol protein methylation amino-acid betaine metabolic process amino-acid betaine catabolic process methyltransferase activity zinc ion binding methionine biosynthetic process transferase activity methylation macromolecular complex macromolecular complex binding metal ion binding betaine-homocysteine S-methyltransferase activity extracellular exosome L-methionine salvage uc007rli.1 uc007rli.2 uc007rli.3 
ENSMUST00000099311.9 Slx4ip ENSMUST00000099311.9 SLX4 interacting protein, transcript variant 1 (from RefSeq NM_028834.3) ENSMUST00000099311.1 ENSMUST00000099311.2 ENSMUST00000099311.3 ENSMUST00000099311.4 ENSMUST00000099311.5 ENSMUST00000099311.6 ENSMUST00000099311.7 ENSMUST00000099311.8 NM_028834 Q6NXK0 Q9CWT7 Q9D7Y9 SLX4I_MOUSE uc008mow.1 uc008mow.2 uc008mow.3 Interacts with SLX4/BTBD12; subunit of different structure- specific endonucleases. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D7Y9-1; Sequence=Displayed; Name=2; IsoId=Q9D7Y9-2; Sequence=VSP_028421; Name=3; IsoId=Q9D7Y9-3; Sequence=VSP_028422, VSP_028423; Belongs to the SLX4IP family. molecular_function cellular_component biological_process uc008mow.1 uc008mow.2 uc008mow.3 
ENSMUST00000099329.5 Ube2n ENSMUST00000099329.5 ubiquitin-conjugating enzyme E2N (from RefSeq NM_080560.3) Blu ENSMUST00000099329.1 ENSMUST00000099329.2 ENSMUST00000099329.3 ENSMUST00000099329.4 NM_080560 P61089 Q16781 Q3TSL6 Q6ZWZ0 Q9DAJ6 UBE2N_MOUSE uc007gwm.1 uc007gwm.2 uc007gwm.3 The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:22424771, PubMed:28039360). This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the RNA- dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:22424771). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence= Activity is inhibited by binding to OTUB1, which prevents 'Lys-63'-linked polyubiquitination (By similarity). Activity is inhibited by GPS2, leading to prevent 'Lys-63'-linked polyubiquitination (PubMed:22424771, PubMed:28039360, PubMed:28123943, PubMed:29499132). Protein modification; protein ubiquitination. Heterodimer with UBE2V2 (By similarity). Interacts (UBE2V2- UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity (By similarity). Interacts with RNF8 and RNF168 (By similarity). Interacts with RNF11 (By similarity). Interacts with the E3 ligases, HLTF and SHPRH; the interactions promote the 'Lys-63'-linked polyubiquitination of PCNA upon genotoxic stress and lead to DNA repair (By similarity). Interacts with ARIH2 (via RING-type 2) (By similarity). Interacts with OTUB1; leading to inhibit E2-conjugating activity (By similarity). Interacts with GPS2; leading to inhibit E2-conjugating activity (PubMed:22424771). Interacts with RIGI and RNF135; involved in RIGI ubiquitination and activation (By similarity). Nucleus Cytoplasm Conjugation to ISG15 impairs formation of the thioester bond with ubiquitin but not interaction with UBE2V2. Belongs to the ubiquitin-conjugating enzyme family. Sequence=BAE36659.1; Type=Frameshift; Evidence=; ubiquitin ligase complex nucleotide binding double-strand break repair via homologous recombination DNA double-strand break processing fibrillar center ubiquitin-protein transferase activity protein binding ATP binding nucleus cytoplasm DNA repair postreplication repair ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus protein ubiquitination histone ubiquitination transferase activity positive regulation of histone modification UBC13-MMS2 complex ubiquitin protein ligase binding macromolecular complex regulation of histone ubiquitination UBC13-UEV1A complex positive regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding positive regulation of DNA repair T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity positive regulation of ubiquitin-protein transferase activity ubiquitin conjugating enzyme activity protein K63-linked ubiquitination uc007gwm.1 uc007gwm.2 uc007gwm.3 
ENSMUST00000099337.5 Plxnc1 ENSMUST00000099337.5 plexin C1 (from RefSeq NM_018797.3) ENSMUST00000099337.1 ENSMUST00000099337.2 ENSMUST00000099337.3 ENSMUST00000099337.4 NM_018797 PLXC1_MOUSE Q8CGW1 Q9QZC2 Vespr uc007gvz.1 uc007gvz.2 uc007gvz.3 uc007gvz.4 uc007gvz.5 Receptor for SEMA7A, for vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). Monomer. Homodimer. Interacts with SEMA7A (By similarity). Membrane ; Single-pass type I membrane protein Detected on dendritic cells, skin Langerhans cells and neutrophils (at protein level). No visible phenotype. Belongs to the plexin family. semaphorin receptor complex integral component of plasma membrane negative regulation of cell adhesion signal transduction regulation of cell shape membrane integral component of membrane semaphorin receptor activity regulation of cell migration regulation of GTPase activity positive regulation of axonogenesis semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway involved in axon guidance uc007gvz.1 uc007gvz.2 uc007gvz.3 uc007gvz.4 uc007gvz.5 
ENSMUST00000099349.10 Hspa12b ENSMUST00000099349.10 heat shock protein 12B (from RefSeq NM_028306.3) ENSMUST00000099349.1 ENSMUST00000099349.2 ENSMUST00000099349.3 ENSMUST00000099349.4 ENSMUST00000099349.5 ENSMUST00000099349.6 ENSMUST00000099349.7 ENSMUST00000099349.8 ENSMUST00000099349.9 HS12B_MOUSE NM_028306 Q9CZJ2 uc008mkr.1 uc008mkr.2 uc008mkr.3 uc008mkr.4 Expressed most strongly in heart with little or no expression in other tissues. In the aorta, preferentially expressed in lesions. Belongs to the heat shock protein 70 family. nucleotide binding molecular_function ATP binding cellular_component biological_process uc008mkr.1 uc008mkr.2 uc008mkr.3 uc008mkr.4 
ENSMUST00000099353.6 Sfr1 ENSMUST00000099353.6 SWI5 dependent recombination repair 1 (from RefSeq NM_026377.2) ENSMUST00000099353.1 ENSMUST00000099353.2 ENSMUST00000099353.3 ENSMUST00000099353.4 ENSMUST00000099353.5 Mei5 Meir5 NM_026377 Q3TH62 Q3TI03 Q3TJK0 Q3UIQ6 Q8BP27 Q8R3W0 Q9CRT7 Q9D0D7 Q9D116 Q9D4W4 SFR1_MOUSE uc008hvk.1 uc008hvk.2 uc008hvk.3 Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:20976249). Acts as a transcriptional modulator for ESR1. Component of the SWI5-SFR1 complex (PubMed:20976249). Interacts with RAD51; the interaction is weak (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BP27-1; Sequence=Displayed; Name=2; IsoId=Q8BP27-2; Sequence=VSP_040905; Name=3; IsoId=Q8BP27-3; Sequence=VSP_040906, VSP_040907; Belongs to the SFR1/MEI5 family. Sequence=BAB23154.1; Type=Frameshift; Evidence=; double-strand break repair via homologous recombination nucleus DNA repair cellular response to DNA damage stimulus ligand-dependent nuclear receptor transcription coactivator activity Swi5-Sfr1 complex positive regulation of transcription, DNA-templated cellular response to estrogen stimulus uc008hvk.1 uc008hvk.2 uc008hvk.3 
ENSMUST00000099356.10 Arrdc3 ENSMUST00000099356.10 arrestin domain containing 3, transcript variant 1 (from RefSeq NM_001042591.2) ARRD3_MOUSE ENSMUST00000099356.1 ENSMUST00000099356.2 ENSMUST00000099356.3 ENSMUST00000099356.4 ENSMUST00000099356.5 ENSMUST00000099356.6 ENSMUST00000099356.7 ENSMUST00000099356.8 ENSMUST00000099356.9 Kiaa1376 NM_001042591 Q4KMN0 Q7TPQ9 Q80TE6 Q8K0L7 uc007rhi.1 uc007rhi.2 uc007rhi.3 uc007rhi.4 uc007rhi.5 Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors (PubMed:21982743). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. Interacts (via PPxY motifs) with NEDD4 (via WW domains). Interacts with ADRB2. Interacts with ADRB3. Interacts with HGS (via PPxY motifs). Does not bind TXN (thioredoxin). Interacts with ITCH. Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Lysosome Endosome Early endosome Note=Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis. Detected in visceral fat, subcutaneous fat, brown fat and skeletal muscle, and at lower levels in kidney. Up-regulated by fasting. Transiently up-regulated during the differentiation of pre-adipocytes. Mice are born at the expected Mendelian rate, but there is important perinatal lethality and the majority do not survive till weaning. Mutant mice have considerably less body mass and accumulate less body fat than wild-type, in spite of normal food intake. Heterozygous mice display higher oxygen uptake, increased activity levels and higher energy expenditure than wild-type. In addition, they display increased expression of genes required for thermogenesis, increased activation of signaling cascades downstream of beta-adrenergic receptors, more rapid readjustment of body temperature when exposed to cold and increased heat production. Belongs to the arrestin family. Sequence=BAC65781.1; Type=Erroneous initiation; Evidence=; temperature homeostasis cytoplasm lysosome endosome early endosome plasma membrane membrane negative regulation of heat generation beta-3 adrenergic receptor binding skin development positive regulation of ubiquitin-protein transferase activity fat pad development negative regulation of adrenergic receptor signaling pathway negative regulation of locomotion involved in locomotory behavior uc007rhi.1 uc007rhi.2 uc007rhi.3 uc007rhi.4 uc007rhi.5 
ENSMUST00000099362.11 Slc4a11 ENSMUST00000099362.11 solute carrier family 4, sodium bicarbonate transporter-like, member 11 (from RefSeq NM_001081162.1) A2AJN7 BTR1 ENSMUST00000099362.1 ENSMUST00000099362.10 ENSMUST00000099362.2 ENSMUST00000099362.3 ENSMUST00000099362.4 ENSMUST00000099362.5 ENSMUST00000099362.6 ENSMUST00000099362.7 ENSMUST00000099362.8 ENSMUST00000099362.9 NM_001081162 Q0VG86 Q3URQ1 S4A11_MOUSE uc008mjv.1 uc008mjv.2 uc008mjv.3 Multifunctional transporter with an impact in cell morphology and differentiation (PubMed:20185830). In the presence of borate B(OH)4(-), acts as a voltage-dependent electrogenic Na(+)-coupled B(OH)4(-) cotransporter controlling boron homeostasis (By similarity). At early stages of stem cell differentiation, participates in synergy with ITGA5-ITGB1 and ITGAV-ITGB3 integrins and BMPR1A to promote cell adhesion and contractility that drives differentiation toward osteogenic commitment while inhibiting adipogenesis (PubMed:33247189). In the absence of B(OH)4(-), acts as a Na(+)-coupled OH(-) or H(+) permeable channel with implications in cellular redox balance. Regulates the oxidative stress response in corneal endothelium by enhancing antioxidant defenses and protecting cells from reactive oxygen species. In response to hypo-osmotic challenge, also acts as water permeable channel at the basolateral cell membrane of corneal endothelial cells and facilitates transendothelial fluid reabsorption in the aqueous humor. In the presence of ammonia, acts as an electrogenic NH3/H(+) cotransporter and may play a role in ammonia transport and reabsorption in renal Henle's loop epithelium (By similarity). Reaction=2 Na(+)(in) + tetrahydroxoborate(in) = 2 Na(+)(out) + tetrahydroxoborate(out); Xref=Rhea:RHEA:66816, ChEBI:CHEBI:29101, ChEBI:CHEBI:41132; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66817; Evidence=; Homodimer. Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Expressed in the endothelial cells of the cornea. In the inner ear, is located in fibrocytes underlying the stria vascularis. In the kidney, is expressed in the thin descending limb of Henle loop. Glycosylated. Mutant mice show corneal defects characterized by progressive thickening of the stroma and descement membrane concomitant with increased sodium chloride concentration in the stroma (PubMed:20185830, PubMed:23813972). They show impaired urinary concentration, increased urinary volume, and increased urinary sodium loss in the kidney. They also show stress-induced morphological changes of fibrocytes of the inner ear resulting in deafness. Belongs to the anion exchanger (TC 2.A.31) family. sodium channel activity inorganic anion exchanger activity plasma membrane ion transport sodium ion transport anion transport bicarbonate transmembrane transporter activity hydrogen ion channel activity symporter activity anion:anion antiporter activity bicarbonate transport membrane integral component of membrane cellular cation homeostasis borate transmembrane transport sodium ion transmembrane transport fluid transport borate transport borate transmembrane transporter activity protein dimerization activity ion homeostasis regulation of intracellular pH anion transmembrane transport hydrogen ion transmembrane transport uc008mjv.1 uc008mjv.2 uc008mjv.3 
ENSMUST00000099373.12 Cnnm2 ENSMUST00000099373.12 cyclin M2, transcript variant 1 (from RefSeq NM_033569.3) A0PJF1 Acdp2 CNNM2_MOUSE E9PUH1 ENSMUST00000099373.1 ENSMUST00000099373.10 ENSMUST00000099373.11 ENSMUST00000099373.2 ENSMUST00000099373.3 ENSMUST00000099373.4 ENSMUST00000099373.5 ENSMUST00000099373.6 ENSMUST00000099373.7 ENSMUST00000099373.8 ENSMUST00000099373.9 NM_033569 Q3TWN3 Q7TT07 Q8C8V4 Q9JIM8 uc008hue.1 uc008hue.2 uc008hue.3 uc008hue.4 Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+). Isoform 1 and isoform 2 may interact with each other. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CNNM2a; IsoId=Q3TWN3-1; Sequence=Displayed; Name=2; Synonyms=CNNM2b; IsoId=Q3TWN3-2; Sequence=VSP_027081; Widely expressed, with highest levels in kidney, lung, spleen and testis. In the kidney, predominantly expressed in the distal convoluted tubule and, at lower levels, in the connecting tubule (at protein level). By low Mg(2+) concentration. The N-terminus is cleaved within the endoplasmic reticulum. The signal peptidase complex seems to be involved in the processing, but the exact cleavage site has not been identified (PubMed:22399287). Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo. Belongs to the ACDP family. Sequence=AAF86373.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH27387.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH52513.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ATP binding plasma membrane ion transport magnesium ion homeostasis magnesium ion transmembrane transporter activity magnesium ion transport membrane integral component of membrane basolateral plasma membrane transmembrane transporter activity intracellular membrane-bounded organelle transmembrane transport magnesium ion transmembrane transport uc008hue.1 uc008hue.2 uc008hue.3 uc008hue.4 
ENSMUST00000099384.4 Brd9 ENSMUST00000099384.4 bromodomain containing 9, transcript variant 4 (from RefSeq NM_001378948.1) A0A0R4J175 A0A0R4J175_MOUSE Brd9 ENSMUST00000099384.1 ENSMUST00000099384.2 ENSMUST00000099384.3 NM_001378948 uc007rej.1 uc007rej.2 uc007rej.3 uc007rej.4 Nucleus SWI/SNF complex lysine-acetylated histone binding uc007rej.1 uc007rej.2 uc007rej.3 uc007rej.4 
ENSMUST00000099393.4 Hps6 ENSMUST00000099393.4 HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 (from RefSeq NM_176785.3) ENSMUST00000099393.1 ENSMUST00000099393.2 ENSMUST00000099393.3 HPS6_MOUSE NM_176785 Q3TWQ8 Q8BLY7 Q8BML5 Q8CIA3 Ru uc008hrx.1 uc008hrx.2 uc008hrx.3 uc008hrx.4 May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (By similarity). Acts as a cargo adapter for the dynein- dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning (PubMed:25189619). Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with dynein intermediate chain (By similarity). Interacts with AP-3 complex (PubMed:19010779). Interacts with DCTN1 (PubMed:25189619). Microsome membrane Cytoplasm, cytosol Early endosome membrane Lysosome membrane Widely expressed, with lowest expression in skeletal muscle. Note=Defects in Hps6 are the cause of Hermansky-Pudlak-like syndrome, a syndrome characterized by hypopigmented eyes and coat, melanosomes greatly reduced in number and morphologically bizarre, kidney proximal tubules secreting lysosomal enzymes into urine at greatly reduced rates, platelet dense granules deficient in critical components, such as serotonin and adenine nucleotides, leading to functionally abnormal platelets and prolonged bleeding times, and mast cell granules undergoing unregulated 'kiss-and-run' fusion at the plasma membrane. protein binding cytoplasm lysosome lysosomal membrane endosome endoplasmic reticulum cytosol organelle organization blood coagulation membrane Rab GTPase binding melanocyte differentiation GTP-dependent protein binding BLOC-2 complex organelle membrane early endosome membrane lysosome localization intracellular membrane-bounded organelle pigmentation protein localization to membrane uc008hrx.1 uc008hrx.2 uc008hrx.3 uc008hrx.4 
ENSMUST00000099396.3 Nt5dc3 ENSMUST00000099396.3 5'-nucleotidase domain containing 3 (from RefSeq NM_175331.3) ENSMUST00000099396.1 ENSMUST00000099396.2 Gnn NM_175331 NT5D3_MOUSE Q3T9W5 Q3UHB1 uc007gqn.1 uc007gqn.2 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Belongs to the 5'(3')-deoxyribonucleotidase family. mitochondrion cytosol 5'-nucleotidase activity dephosphorylation hydrolase activity receptor complex metal ion binding uc007gqn.1 uc007gqn.2 
ENSMUST00000099400.3 Papolb ENSMUST00000099400.3 poly (A) polymerase beta (testis specific) (from RefSeq NM_019943.2) ENSMUST00000099400.1 ENSMUST00000099400.2 NM_019943 PAPOB_MOUSE Papolb Papt Q9R1R3 Q9WVP6 Tpap uc009aiw.1 uc009aiw.2 uc009aiw.3 Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, ChEBI:CHEBI:173115; EC=2.7.7.19; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium ions. Also active with manganese. ; Interacts with GSG1. Q9WVP6; Q8R1W2: Gsg1; NbExp=8; IntAct=EBI-7842113, EBI-7842142; Cytoplasm. Nucleus. Testis specific. Expressed at low levels in 2-week-old mice. Abundantly expressed in 4-week-old and 6-week-old animals. Belongs to the poly(A) polymerase family. Sequence=AAD43624.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding RNA binding polynucleotide adenylyltransferase activity protein binding ATP binding nucleus cytoplasm endoplasmic reticulum mRNA polyadenylation mRNA processing transferase activity nucleotidyltransferase activity RNA 3'-end processing RNA polyadenylation metal ion binding uc009aiw.1 uc009aiw.2 uc009aiw.3 
ENSMUST00000099401.6 Lbx1 ENSMUST00000099401.6 ladybird homeobox 1 (from RefSeq NM_010691.6) ENSMUST00000099401.1 ENSMUST00000099401.2 ENSMUST00000099401.3 ENSMUST00000099401.4 ENSMUST00000099401.5 LBX1_MOUSE Lbx1h NM_010691 P52955 Q3UN09 Q80XA3 uc008hqv.1 uc008hqv.2 uc008hqv.3 Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. Interacts with SKOR1 which acts as a transcriptional corepressor. P52955; Q8BX46: Skor1; NbExp=2; IntAct=EBI-604594, EBI-604451; Nucleus Expressed in the dorsal part of the spinal cord and hindbrain and in presumptive myogenic cells in lateral regions of differentiating somites. Expressed in the developing central nervous system from 10.5 dpc to 16.5 dpc. Expressed in presumptive myogenic cells from 9.5 dpc until 16.5 dpc with highest levels at 10.5-11.5 dpc. Death at birth. Mice fail to expand their lungs and do not move their abnormally thin limbs. Sequence=BAE25939.1; Type=Erroneous initiation; Evidence=; heart looping DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated multicellular organism development nervous system development muscle organ development negative regulation of cell proliferation spinal cord motor neuron differentiation regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification cell differentiation sequence-specific DNA binding negative regulation of neuron differentiation neuron fate commitment neuron fate determination uc008hqv.1 uc008hqv.2 uc008hqv.3 
ENSMUST00000099414.5 Zfp955b ENSMUST00000099414.5 zinc finger protein 955B (from RefSeq NM_001142957.1) ENSMUST00000099414.1 ENSMUST00000099414.2 ENSMUST00000099414.3 ENSMUST00000099414.4 L7N232 L7N232_MOUSE NM_001142957 Zfp955b uc008byh.1 uc008byh.2 uc008byh.3 uc008byh.4 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc008byh.1 uc008byh.2 uc008byh.3 uc008byh.4 
ENSMUST00000099425.3 Gm10775 ENSMUST00000099425.3 predicted gene 10775 (from RefSeq NR_188828.1) ENSMUST00000099425.1 ENSMUST00000099425.2 Gm10775 NR_188828 Q3V290 Q3V290_MOUSE uc288nyd.1 uc288nyd.2 molecular_function cellular_component biological_process uc288nyd.1 uc288nyd.2 
ENSMUST00000099427.3 Spata31d1c ENSMUST00000099427.3 spermatogenesis associated 31 subfamily D, member 1C (from RefSeq NM_001083890.3) E9QAF1 E9QAF1_MOUSE ENSMUST00000099427.1 ENSMUST00000099427.2 NM_001083890 Spata31d1c uc007qzb.1 uc007qzb.2 Membrane ; Single- pass membrane protein Belongs to the SPATA31 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007qzb.1 uc007qzb.2 
ENSMUST00000099428.5 Hpse2 ENSMUST00000099428.5 heparanase 2 (from RefSeq NM_001081257.3) B2RY83 ENSMUST00000099428.1 ENSMUST00000099428.2 ENSMUST00000099428.3 ENSMUST00000099428.4 HPSE2_MOUSE Hpa2 NM_001081257 uc008hoe.1 uc008hoe.2 uc008hoe.3 uc008hoe.4 uc008hoe.5 Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) (By similarity). Interacts with HPSE. Interacts with SDC1 (via glycan chains) (By similarity). Secreted, extracellular space, extracellular matrix Belongs to the glycosyl hydrolase 79 family. extracellular region positive regulation of cell proliferation membrane hydrolase activity, acting on glycosyl bonds extracellular matrix organization extracellular matrix heparan sulfate proteoglycan binding uc008hoe.1 uc008hoe.2 uc008hoe.3 uc008hoe.4 uc008hoe.5 
ENSMUST00000099441.6 Slc35d2 ENSMUST00000099441.6 solute carrier family 35, member D2 (from RefSeq NM_001001321.3) A0A0R4J181 A0A0R4J181_MOUSE ENSMUST00000099441.1 ENSMUST00000099441.2 ENSMUST00000099441.3 ENSMUST00000099441.4 ENSMUST00000099441.5 NM_001001321 Slc35d2 uc007qyg.1 uc007qyg.2 uc007qyg.3 Membrane ; Multi- pass membrane protein membrane integral component of membrane uc007qyg.1 uc007qyg.2 uc007qyg.3 
ENSMUST00000099443.11 Zfyve27 ENSMUST00000099443.11 zinc finger, FYVE domain containing 27, transcript variant 2 (from RefSeq NM_001164531.1) ENSMUST00000099443.1 ENSMUST00000099443.10 ENSMUST00000099443.2 ENSMUST00000099443.3 ENSMUST00000099443.4 ENSMUST00000099443.5 ENSMUST00000099443.6 ENSMUST00000099443.7 ENSMUST00000099443.8 ENSMUST00000099443.9 NM_001164531 Q3TXX3 Q8CFP8 ZFY27_MOUSE uc008hnj.1 uc008hnj.2 uc008hnj.3 uc008hnj.4 uc008hnj.5 Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (By similarity). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (PubMed:24251978). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (By similarity). Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701). Can form homooligomers (monomers, dimers and tetramers) (By similarity). Interacts with RAB11A (GDP-bound form); regulates RAB11A (PubMed:21976701). Interacts with FKBP8; may negatively regulate ZFYVE27 phosphorylation (By similarity). Isoform 1 interacts to a greater extent than isoform 2 with VAPB (via MSP domain). Isoform 1 interacts to a greater extent than isoform 2 with VAPA (via MSP domain) (PubMed:24251978). Interaction with VAPA may regulate ZFYVE27 retention in the endoplasmic reticulum and its function in cell projections formation. Interacts with ATL2, ATL3, SPAST and RTN3 (By similarity). Interacts with REEP1, REEP5 and ATL1 (PubMed:24668814). Interacts with RAB11B (GDP-bound form), SURF4, KIF5B and KIF5C (PubMed:21976701). Isoform 1 and 2 interact with KIFA (PubMed:21976701, PubMed:24251978). Recycling endosome membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Cell projection, growth cone membrane ; Multi-pass membrane protein Note=Localizes at both dendrites and axons (PubMed:17082457). Localizes to endoplasmic reticulum tubular network. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Protrudin-L ; IsoId=Q3TXX3-1; Sequence=Displayed; Name=2; Synonyms=Protrudin-S ; IsoId=Q3TXX3-2; Sequence=VSP_019757; Astrocytes express both isoform 1 and isoform 2 and oligodendrocytes express only isoform 2 (at protein level). Isoform 1 is expressed specifically in the central nervous system and selectively in neuronal cells. Isoform 2 is expressed in cerebrum, cerebellum, spinal cord, heart, thymus, spleen, intestine and lung. Phosphorylated. Phosphorylation is induced by NGF through the MAPK/ERK pathway and modulates interaction with RAB11A (Probable). Sequence=AAH42595.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding nucleoplasm cytoplasm endosome endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane membrane integral component of membrane vesicle-mediated transport integral component of endoplasmic reticulum membrane axon dendrite neuron projection development growth cone membrane cell projection protein self-association positive regulation of axon extension metal ion binding neurotrophin TRK receptor signaling pathway recycling endosome membrane endoplasmic reticulum tubular network endoplasmic reticulum tubular network assembly protein localization to plasma membrane uc008hnj.1 uc008hnj.2 uc008hnj.3 uc008hnj.4 uc008hnj.5 
ENSMUST00000099446.6 E430024I08Rik ENSMUST00000099446.6 E430024I08Rik (from geneSymbol) ENSMUST00000099446.1 ENSMUST00000099446.2 ENSMUST00000099446.3 ENSMUST00000099446.4 ENSMUST00000099446.5 uc288ooq.1 uc288ooq.2 uc288ooq.3 uc288ooq.1 uc288ooq.2 uc288ooq.3 
ENSMUST00000099449.4 Zfp808 ENSMUST00000099449.4 zinc finger protein 808 (from RefSeq NM_001039239.2) B8JJZ4 B8JJZ4_MOUSE ENSMUST00000099449.1 ENSMUST00000099449.2 ENSMUST00000099449.3 NM_001039239 Zfp808 uc007qws.1 uc007qws.2 uc007qws.3 Nucleus nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007qws.1 uc007qws.2 uc007qws.3 
ENSMUST00000099452.3 Ctxn2 ENSMUST00000099452.3 Membrane ; Single- pass membrane protein (from UniProt A0A0R4J179) A0A0R4J179 A0A0R4J179_MOUSE AK141570 Ctxn2 ENSMUST00000099452.1 ENSMUST00000099452.2 uc008mce.1 uc008mce.2 uc008mce.3 uc008mce.4 Membrane ; Single- pass membrane protein membrane integral component of membrane uc008mce.1 uc008mce.2 uc008mce.3 uc008mce.4 
ENSMUST00000099461.4 Duox1 ENSMUST00000099461.4 dual oxidase 1 (from RefSeq NM_001099297.1) A2AQ92 A2AQ92_MOUSE Duox1 ENSMUST00000099461.1 ENSMUST00000099461.2 ENSMUST00000099461.3 NM_001099297 uc008map.1 uc008map.2 Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. Reaction=H(+) + NADH + O2 = H2O2 + NAD(+); Xref=Rhea:RHEA:11264, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.3.1; Evidence=; Reaction=H(+) + NADPH + O2 = H2O2 + NADP(+); Xref=Rhea:RHEA:11260, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.6.3.1; Evidence=; Hormone biosynthesis; thyroid hormone biosynthesis. Apical cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein In the N-terminal section; belongs to the peroxidase family. peroxidase activity calcium ion binding protein binding endoplasmic reticulum plasma membrane defense response response to oxidative stress cell surface membrane integral component of membrane NAD(P)H oxidase activity superoxide-generating NADPH oxidase activity oxidoreductase activity cytokine-mediated signaling pathway heme binding cell leading edge cuticle development superoxide anion generation NADPH oxidase complex hydrogen peroxide biosynthetic process response to cAMP oxidation-reduction process reactive oxygen species metabolic process positive regulation of wound healing cellular oxidant detoxification positive regulation of cell motility uc008map.1 uc008map.2 
ENSMUST00000099466.10 Sorbs1 ENSMUST00000099466.10 sorbin and SH3 domain containing 1, transcript variant 5 (from RefSeq NM_001034964.1) E9QNA7 E9QNA7_MOUSE ENSMUST00000099466.1 ENSMUST00000099466.2 ENSMUST00000099466.3 ENSMUST00000099466.4 ENSMUST00000099466.5 ENSMUST00000099466.6 ENSMUST00000099466.7 ENSMUST00000099466.8 ENSMUST00000099466.9 NM_001034964 Sorbs1 uc008hkm.1 uc008hkm.2 uc008hkm.3 uc008hkm.1 uc008hkm.2 uc008hkm.3 
ENSMUST00000099471.3 Mageb1 ENSMUST00000099471.3 Mageb1 (from geneSymbol) BC119227 ENSMUST00000099471.1 ENSMUST00000099471.2 Mageb1 Mageb2 Q4U221 Q4U221_MOUSE uc292pjw.1 uc292pjw.2 molecular_function cellular_component biological_process uc292pjw.1 uc292pjw.2 
ENSMUST00000099472.4 Cyp2c68 ENSMUST00000099472.4 cytochrome P450, family 2, subfamily c, polypeptide 68 (from RefSeq NM_001039555.2) Cyp2c68 ENSMUST00000099472.1 ENSMUST00000099472.2 ENSMUST00000099472.3 K7N6C2 K7N6C2_MOUSE NM_001039555 uc008hkd.1 uc008hkd.2 uc008hkd.3 uc008hkd.4 Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc008hkd.1 uc008hkd.2 uc008hkd.3 uc008hkd.4 
ENSMUST00000099490.3 Nsd1 ENSMUST00000099490.3 nuclear receptor-binding SET-domain protein 1, transcript variant 1 (from RefSeq NM_008739.3) E9QAE4 E9QAE4_MOUSE ENSMUST00000099490.1 ENSMUST00000099490.2 NM_008739 Nsd1 uc007qqd.1 uc007qqd.2 Nucleus regulation of histone H3-K36 methylation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription cofactor activity nucleus zinc ion binding histone H3-K36 methylation histone-lysine N-methyltransferase activity regulation of peptidyl-serine phosphorylation histone lysine methylation positive regulation of transcription, DNA-templated metal ion binding histone methyltransferase activity (H3-K36 specific) androgen receptor binding regulation of RNA polymerase II regulatory region sequence-specific DNA binding uc007qqd.1 uc007qqd.2 
ENSMUST00000099494.4 Btaf1 ENSMUST00000099494.4 B-TFIID TATA-box binding protein associated factor 1 (from RefSeq NM_001080706.1) Btaf1 E9QAE3 E9QAE3_MOUSE ENSMUST00000099494.1 ENSMUST00000099494.2 ENSMUST00000099494.3 NM_001080706 uc008hhw.1 uc008hhw.2 uc008hhw.3 Nucleus DNA binding ATP binding nucleus nucleoplasm DNA-dependent ATPase activity negative regulation of chromatin binding intracellular membrane-bounded organelle uc008hhw.1 uc008hhw.2 uc008hhw.3 
ENSMUST00000099498.10 Ccdc80 ENSMUST00000099498.10 Promotes cell adhesion and matrix assembly. (from UniProt Q8R2G6) A1A4B0 AK144183 CCD80_MOUSE ENSMUST00000099498.1 ENSMUST00000099498.2 ENSMUST00000099498.3 ENSMUST00000099498.4 ENSMUST00000099498.5 ENSMUST00000099498.6 ENSMUST00000099498.7 ENSMUST00000099498.8 ENSMUST00000099498.9 Q3V1Y4 Q4VA97 Q6PDE5 Q8C043 Q8R2G6 Q9CRM1 Q9CT39 Q9D6Z4 Urb uc007zif.1 uc007zif.2 uc007zif.3 Promotes cell adhesion and matrix assembly. Binds to various extracellular matrix proteins. Secreted, extracellular space, extracellular matrix Expressed in brain, stomach, colon, rectum, liver, lung, kidney, adipocytes and testis. Expressed in embryo at 7 dpc onwards. Expressed in rib, sternal cartilage, heart, kidney, leg muscles, intestine and limb at 7 dpc. Expressed in chondrocytes at 14.5 dpc. Expressed in cartilage at 14 dpc. Present in rib cartilage and choroid plexus epithelium at 16.5 dpc (at protein level). Up-regulated in adipose tissue of obese BRS-3-deficient mice. Phosphorylated. Belongs to the CCDC80 family. Sequence=AAH58751.1; Type=Erroneous initiation; Evidence=; Sequence=BAB26508.1; Type=Frameshift; Evidence=; Sequence=BAB32018.1; Type=Frameshift; Evidence=; Sequence=BAC27834.1; Type=Frameshift; Evidence=; fibronectin binding glycosaminoglycan binding extracellular region basement membrane interstitial matrix extracellular space heparin binding response to bacterium positive regulation of cell-substrate adhesion extracellular matrix organization extracellular matrix uc007zif.1 uc007zif.2 uc007zif.3 
ENSMUST00000099502.9 Brwd1 ENSMUST00000099502.9 bromodomain and WD repeat domain containing 1, transcript variant 1 (from RefSeq NM_145125.3) BRWD1_MOUSE E9QAC1 ENSMUST00000099502.1 ENSMUST00000099502.2 ENSMUST00000099502.3 ENSMUST00000099502.4 ENSMUST00000099502.5 ENSMUST00000099502.6 ENSMUST00000099502.7 ENSMUST00000099502.8 NM_145125 Q921C2 Q921C3 Wdr9 uc008acm.1 uc008acm.2 uc008acm.3 uc008acm.4 May be a transcriptional activator. May be involved in chromatin remodeling. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Interacts with SMARCA4. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=Q921C3-1; Sequence=Displayed; Name=B; IsoId=Q921C3-2; Sequence=VSP_018552, VSP_018553; Ubiquitously expressed. Broadly expressed during development. Expression begins to increase at 7.5 dpc, peaks at 10.5-11.5 dpc, and decreases from 14.5 dpc. Weakly expressed at late embryonic stages. protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol regulation of transcription from RNA polymerase II promoter cytoskeleton organization regulation of cell shape uc008acm.1 uc008acm.2 uc008acm.3 uc008acm.4 
ENSMUST00000099508.4 Kcnj6 ENSMUST00000099508.4 potassium inwardly-rectifying channel, subfamily J, member 6, transcript variant Girk2A-1 (from RefSeq NM_010606.2) ENSMUST00000099508.1 ENSMUST00000099508.2 ENSMUST00000099508.3 Kcnj6 NM_010606 Q0VB45 Q0VB45_MOUSE uc008abm.1 uc008abm.2 uc008abm.3 Membrane ulti-pass membrane protein Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily. inward rectifier potassium channel activity voltage-gated ion channel activity ion transport potassium ion transport G-protein activated inward rectifier potassium channel activity membrane integral component of membrane ion transmembrane transport regulation of ion transmembrane transport potassium ion transmembrane transport uc008abm.1 uc008abm.2 uc008abm.3 
ENSMUST00000099513.8 Hcn2 ENSMUST00000099513.8 hyperpolarization-activated, cyclic nucleotide-gated K+ 2 (from RefSeq NM_008226.2) Bcng2 ENSMUST00000099513.1 ENSMUST00000099513.2 ENSMUST00000099513.3 ENSMUST00000099513.4 ENSMUST00000099513.5 ENSMUST00000099513.6 ENSMUST00000099513.7 HCN2_MOUSE Hac1 NM_008226 O70506 O88703 uc007fzn.1 uc007fzn.2 Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. cAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening. Channel activity is modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages. Homotetramer. Heterotetramer with HCN1. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. Forms an obligate 4:4 complex with accessory subunit PEX5L. Interacts with KCNE2. O88703; Q8IYB4-6: PEX5L; Xeno; NbExp=18; IntAct=EBI-771231, EBI-16150786; O88703; P00523: SRC; Xeno; NbExp=5; IntAct=EBI-771231, EBI-848039; Cell membrane ulti-pass membrane protein Highly expressed in brain. Detected at low levels in heart, in ventricle, atrium and in sinoatrial node (SAN). The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Phosphorylation at Ser-641 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating. Belongs to the potassium channel HCN family. nucleotide binding ion channel activity intracellular cAMP activated cation channel activity voltage-gated ion channel activity voltage-gated sodium channel activity voltage-gated potassium channel activity potassium channel activity sodium channel activity protein binding cytoplasm plasma membrane integral component of plasma membrane ion transport potassium ion transport sodium ion transport membrane integral component of membrane PDZ domain binding axon cAMP binding dendrite membrane regulation of ion transmembrane transport sodium ion transmembrane transport somatodendritic compartment regulation of membrane potential identical protein binding neuronal cell body dendritic shaft macromolecular complex binding synapse transmembrane transport binding, bridging cellular response to cAMP cellular response to cGMP potassium ion transmembrane transport sodium ion import across plasma membrane HCN channel complex potassium ion import across plasma membrane uc007fzn.1 uc007fzn.2 
ENSMUST00000099514.10 Sgms1 ENSMUST00000099514.10 sphingomyelin synthase 1, transcript variant 2 (from RefSeq NM_144792.5) ENSMUST00000099514.1 ENSMUST00000099514.2 ENSMUST00000099514.3 ENSMUST00000099514.4 ENSMUST00000099514.5 ENSMUST00000099514.6 ENSMUST00000099514.7 ENSMUST00000099514.8 ENSMUST00000099514.9 NM_144792 Q3UIS8 Q5J3R0 Q8C464 Q8C583 Q8C652 Q8VCQ6 SMS1_MOUSE Tmem23 uc008hfg.1 uc008hfg.2 uc008hfg.3 uc008hfg.4 Major sphingomyelin synthase at the Golgi apparatus (By similarity). Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes (By similarity). Does not use free phosphorylcholine or CDP- choline as donor. Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:22580896, PubMed:16879426) (By similarity). Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (By similarity). (Microbial infection) Contributes to the brain SM production for Japanese encephalitis virus attachment and infection. Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4- enine = a 1,2-diacyl-sn-glycerol + a sphingomyelin; Xref=Rhea:RHEA:18765, ChEBI:CHEBI:17636, ChEBI:CHEBI:17815, ChEBI:CHEBI:52639, ChEBI:CHEBI:57643; EC=2.7.8.27; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18766; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18767; Evidence=; Reaction=1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N- acylsphing-4-enine; Xref=Rhea:RHEA:43320, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:78421, ChEBI:CHEBI:82983; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43321; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:43322; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + N- hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl- sphinganine-1-phosphocholine; Xref=Rhea:RHEA:41796, ChEBI:CHEBI:17815, ChEBI:CHEBI:57643, ChEBI:CHEBI:67042, ChEBI:CHEBI:78647; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41797; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:41798; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl- (4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl- (4R)-hydroxysphinganine-phosphocholine; Xref=Rhea:RHEA:42140, ChEBI:CHEBI:17815, ChEBI:CHEBI:57643, ChEBI:CHEBI:65107, ChEBI:CHEBI:78650; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42141; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42142; Evidence=; Sphingolipid metabolism. Golgi apparatus membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=SMS1-alpha; IsoId=Q8VCQ6-1; Sequence=Displayed; Name=2; Synonyms=SMS1-beta; IsoId=Q8VCQ6-2; Sequence=VSP_050673; Name=3; Synonyms=SMS1-gamma; IsoId=Q8VCQ6-3; Sequence=VSP_027225, VSP_027226; Isoform 1 is widely expressed, isoform 2 shows a more narrow distribution and isoform 3 is detected only in testis and heart. [Isoform 1]: Induced by TNF-alpha. [Isoform 2]: Induced by TNF-alpha. Null mice have hearing impairments with stria vascularis (SV) in these mice exhibiting atrophy and disorganized marginal cells resulting in significantly smaller endocochlear potentials (EPs). These decreased EPs, together with abnormal KCNQ1 expression patterns, increase with age. There is a decrease in plasma, liver, and macrophage sphingomyelin (59%, 45%, and 54%, respectively) and a dramatic increase in glycosphingolipids. No change in ceramide, total cholesterol, phospholipids nor triglycerides levels. Diminished macrophage MAP kinase and NFKB1 activation is observed. Atherosclerosis in SMS1(-/-)/LDLR(-/-) mice is significantly decreased. Belongs to the sphingomyelin synthase family. Golgi trans cisterna Golgi membrane ceramide phosphoethanolamine synthase activity nucleus endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane lipid metabolic process sphingolipid metabolic process sphingomyelin biosynthetic process apoptotic process inflammatory response positive regulation of gene expression membrane integral component of membrane kinase activity phosphorylation transferase activity sphingolipid biosynthetic process integral component of Golgi membrane integral component of endoplasmic reticulum membrane sphingomyelin synthase activity ceramide biosynthetic process ceramide cholinephosphotransferase activity cellular response to lipopolysaccharide cellular response to tumor necrosis factor negative regulation of extrinsic apoptotic signaling pathway uc008hfg.1 uc008hfg.2 uc008hfg.3 uc008hfg.4 
ENSMUST00000099518.4 Spata31e4 ENSMUST00000099518.4 spermatogenesis associated 31 subfamily E member 4 (from RefSeq NM_001244649.1) B7ZWJ3 B7ZWJ3_MOUSE EG667693 ENSMUST00000099518.1 ENSMUST00000099518.2 ENSMUST00000099518.3 Gm8765 NM_001244649 uc029sav.1 uc029sav.2 uc029sav.3 Membrane ; Single- pass membrane protein Belongs to the SPATA31 family. molecular_function cellular_component biological_process uc029sav.1 uc029sav.2 uc029sav.3 
ENSMUST00000099521.2 Spata31e3 ENSMUST00000099521.2 spermatogenesis associated 31 subfamily E member 3 (from RefSeq NM_001033438.2) ENSMUST00000099521.1 Gm8765 Gm906 NM_001033438 Q3V0M1 Q3V0M1_MOUSE uc007qka.1 uc007qka.2 Membrane ; Single- pass membrane protein Belongs to the SPATA31 family. molecular_function cellular_component biological_process uc007qka.1 uc007qka.2 
ENSMUST00000099525.5 Ranbp6 ENSMUST00000099525.5 RAN binding protein 6 (from RefSeq NM_177721.4) ENSMUST00000099525.1 ENSMUST00000099525.2 ENSMUST00000099525.3 ENSMUST00000099525.4 NM_177721 Q3TTJ6 Q8BIV3 RNBP6_MOUSE uc008heb.1 uc008heb.2 uc008heb.3 uc008heb.4 May function in nuclear protein import as nuclear transport receptor. Cytoplasm Nucleus Belongs to the importin beta family. Sequence=BAC38756.1; Type=Erroneous initiation; Evidence=; Sequence=BAE36329.1; Type=Erroneous initiation; Evidence=; nucleus cytoplasm protein import into nucleus nuclear localization sequence binding protein transport nuclear import signal receptor activity uc008heb.1 uc008heb.2 uc008heb.3 uc008heb.4 
ENSMUST00000099536.4 Gm815 ENSMUST00000099536.4 predicted gene 815 (from RefSeq NM_001033407.2) ENSMUST00000099536.1 ENSMUST00000099536.2 ENSMUST00000099536.3 Gm815 NM_001033407 Q3UWS2 Q3UWS2_MOUSE uc008hbs.1 uc008hbs.2 uc008hbs.3 uc008hbs.4 molecular_function cellular_component biological_process uc008hbs.1 uc008hbs.2 uc008hbs.3 uc008hbs.4 
ENSMUST00000099542.9 Knl1 ENSMUST00000099542.9 kinetochore scaffold 1, transcript variant 1 (from RefSeq NM_029617.3) A3KGI3 A3KGI3_MOUSE ENSMUST00000099542.1 ENSMUST00000099542.2 ENSMUST00000099542.3 ENSMUST00000099542.4 ENSMUST00000099542.5 ENSMUST00000099542.6 ENSMUST00000099542.7 ENSMUST00000099542.8 Knl1 NM_029617 uc008lta.1 uc008lta.2 condensed chromosome kinetochore acrosomal vesicle nucleus nucleoplasm cytosol attachment of spindle microtubules to kinetochore negative regulation of phosphatase activity nuclear body protein localization to kinetochore uc008lta.1 uc008lta.2 
ENSMUST00000099546.6 Chst14 ENSMUST00000099546.6 carbohydrate sulfotransferase 14 (from RefSeq NM_028117.3) A2AQV3 CHSTE_MOUSE D4st1 ENSMUST00000099546.1 ENSMUST00000099546.2 ENSMUST00000099546.3 ENSMUST00000099546.4 ENSMUST00000099546.5 NM_028117 Q3TXA1 Q80V53 Q8R304 Q9D0P2 uc012cbn.1 uc012cbn.2 uc012cbn.3 uc012cbn.4 Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development. Reaction=n 3'-phosphoadenylyl sulfate + dermatan = n adenosine 3',5'- bisphosphate + dermatan 4'-sulfate + n H(+); Xref=Rhea:RHEA:48052, Rhea:RHEA-COMP:9965, Rhea:RHEA-COMP:11986, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58465, ChEBI:CHEBI:60059; EC=2.8.2.35; Evidence=; Golgi apparatus membrane ; Single- pass type II membrane protein Low levels of expression in olfactory bulb, caudate putamen, cerebral cortex, hippocampus, thalamus, midbrain and cerebellum during early postnatal development. In later stages, exclusively expressed in cerebellum culminating at P14 of postnatal development. Belongs to the sulfotransferase 2 family. Golgi membrane N-acetylgalactosamine 4-O-sulfotransferase activity protein binding Golgi apparatus carbohydrate metabolic process sulfotransferase activity membrane integral component of membrane carbohydrate biosynthetic process transferase activity dermatan sulfate biosynthetic process dermatan sulfate proteoglycan metabolic process uc012cbn.1 uc012cbn.2 uc012cbn.3 uc012cbn.4 
ENSMUST00000099547.4 Fam8a1 ENSMUST00000099547.4 family with sequence similarity 8, member A1, transcript variant 2 (from RefSeq NM_001377109.1) C78339 ENSMUST00000099547.1 ENSMUST00000099547.2 ENSMUST00000099547.3 Fam8a1 NM_001377109 Q3URQ4 Q3URQ4_MOUSE uc007qhi.1 uc007qhi.2 uc007qhi.3 Membrane ; Multi- pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007qhi.1 uc007qhi.2 uc007qhi.3 
ENSMUST00000099552.3 Gm10787 ENSMUST00000099552.3 predicted gene 10787 (from RefSeq NR_045882.1) ENSMUST00000099552.1 ENSMUST00000099552.2 NR_045882 uc007fvb.1 uc007fvb.2 uc007fvb.1 uc007fvb.2 
ENSMUST00000099554.5 Mis18a ENSMUST00000099554.5 MIS18 kinetochore protein A (from RefSeq NM_025642.1) ENSMUST00000099554.1 ENSMUST00000099554.2 ENSMUST00000099554.3 ENSMUST00000099554.4 MS18A_MOUSE NM_025642 Q9CZJ6 uc007zwj.1 uc007zwj.2 uc007zwj.3 Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. Homodimer, and heterodimer with OIP5/MIS18B. Identified in a complex containing MIS18A, OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4. Nucleus Chromosome Chromosome, centromere Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin. Belongs to the mis18 family. chromosome, centromeric region chromatin protein binding nucleus chromosome cytosol cell cycle chromosome segregation CENP-A containing nucleosome assembly regulation of DNA methylation metal ion binding cell division uc007zwj.1 uc007zwj.2 uc007zwj.3 
ENSMUST00000099556.2 Pabir1 ENSMUST00000099556.2 PP2A A alpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 (from RefSeq NM_026520.4) ENSMUST00000099556.1 Fam122a NM_026520 PBIR1_MOUSE Pabir1 Q3TA50 Q9D078 Q9DB52 uc008haq.1 uc008haq.2 uc008haq.3 Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (By similarity). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (By similarity). Interacts with PPP2CA, PPP2R2A and PPP2R1A (By similarity). The CHEK1-mediated Ser-34 phosphorylated form interacts with 14-3-3 proteins (By similarity). Nucleus Cytoplasm Note=The CHEK1-mediated Ser-34 phosphorylated form is sequestered by 14-3-3 proteins in the cytoplasm and fails to translocate to the nucleus, where it otherwise inhibits serine/threonine-protein phosphatase 2A. CHEK1-mediated phosphorylation at Ser-34 negatively regulates its ability to inhibit serine/threonine-protein phosphatase 2A (PP2A) activity. Phosphorylation leads to its release from the PP2A complex and its sequestration by 14-3-3 proteins in the cytoplasm resulting in its inability to translocate to the nucleus, where it otherwise inhibits PP2A. Belongs to the FAM122 family. protein serine/threonine phosphatase inhibitor activity cellular_component positive regulation of cell growth positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of phosphoprotein phosphatase activity uc008haq.1 uc008haq.2 uc008haq.3 
ENSMUST00000099557.10 Pak6 ENSMUST00000099557.10 p21 (RAC1) activated kinase 6, transcript variant 4 (from RefSeq NM_001424762.1) ENSMUST00000099557.1 ENSMUST00000099557.2 ENSMUST00000099557.3 ENSMUST00000099557.4 ENSMUST00000099557.5 ENSMUST00000099557.6 ENSMUST00000099557.7 ENSMUST00000099557.8 ENSMUST00000099557.9 NM_001424762 PAK6_MOUSE Q3TY26 Q3ULB5 uc008lsf.1 uc008lsf.2 uc008lsf.3 uc008lsf.4 Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR- mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with the androgen receptor AR. Interacts with IQGAP1 and PPM1B (By similarity). Cytoplasm Nucleus Note=Cotranslocates into nucleus with AR in response to androgen induction. Autophosphorylated. Phosphorylated by MAP2K6/MAPKK6, leading to PAK6 activation (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. nucleotide binding fibrillar center protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation learning memory locomotory behavior kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation cell junction activation of protein kinase activity uc008lsf.1 uc008lsf.2 uc008lsf.3 uc008lsf.4 
ENSMUST00000099558.5 Tjp2 ENSMUST00000099558.5 tight junction protein 2, transcript variant 2 (from RefSeq NM_011597.5) ENSMUST00000099558.1 ENSMUST00000099558.2 ENSMUST00000099558.3 ENSMUST00000099558.4 NM_011597 Q8K210 Q9Z0U1 ZO2_MOUSE Zo2 uc008ham.1 uc008ham.2 uc008ham.3 uc008ham.4 Plays a role in tight junctions and adherens junctions (PubMed:10026224). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (PubMed:22437732). Homodimer (By similarity). Interacts (via PDZ2 domain) with TJP1/ZO1 (via PDZ2 domain) (PubMed:10026224). Interacts with UBN1 (By similarity). Interacts with SCRIB (By similarity). Interacts with OCLN (PubMed:10026224). Interacts with SAFB in the nucleus (PubMed:12403786). Interacts with USP53 (via the C-terminal region) (PubMed:26609154). Interacts with claudins, including CLDN1, CLDN2, CLDN3, CLDN5 and CLDN7 (By similarity). Interacts with CLDN18 (PubMed:22437732). Interacts (via N-terminus) with CTNNA1 (PubMed:10026224). Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus Cell junction, tight junction Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. Belongs to the MAGUK family. protein binding nucleus nucleoplasm cytosol plasma membrane cell-cell junction gap junction bicellular tight junction protein C-terminus binding cell surface membrane protein domain specific binding cell junction protein binding, bridging intestinal absorption occluding junction TNFSF11-mediated signaling pathway establishment of endothelial intestinal barrier regulation of membrane permeability negative regulation of osteoclast development uc008ham.1 uc008ham.2 uc008ham.3 uc008ham.4 
ENSMUST00000099572.10 Prmt2 ENSMUST00000099572.10 protein arginine N-methyltransferase 2, transcript variant 3 (from RefSeq NM_001302965.1) ENSMUST00000099572.1 ENSMUST00000099572.2 ENSMUST00000099572.3 ENSMUST00000099572.4 ENSMUST00000099572.5 ENSMUST00000099572.6 ENSMUST00000099572.7 ENSMUST00000099572.8 ENSMUST00000099572.9 Hrmt1l1 NM_001302965 Prmt2 Q3UID4 Q3UID4_MOUSE uc011xgw.1 uc011xgw.2 uc011xgw.3 uc011xgw.4 transcription coactivator activity nucleus nucleoplasm cytoplasm cytosol protein methylation methyltransferase activity histone methylation transferase activity estrogen receptor binding negative regulation of NF-kappaB transcription factor activity methylation progesterone receptor binding histone methyltransferase activity protein homodimerization activity retinoic acid receptor binding peroxisome proliferator activated receptor binding positive regulation of apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated thyroid hormone receptor binding androgen receptor binding regulation of androgen receptor signaling pathway uc011xgw.1 uc011xgw.2 uc011xgw.3 uc011xgw.4 
ENSMUST00000099575.4 Grem1 ENSMUST00000099575.4 gremlin 1, DAN family BMP antagonist (from RefSeq NM_011824.4) ENSMUST00000099575.1 ENSMUST00000099575.2 ENSMUST00000099575.3 Grem1 NM_011824 Q3TNY7 Q3TNY7_MOUSE uc008lpp.1 uc008lpp.2 uc008lpp.3 uc008lpp.4 Secreted Belongs to the DAN family. negative regulation of leukocyte chemotaxis cytokine activity extracellular region extracellular space apoptotic process signal transduction cell surface negative regulation of cell growth positive regulation of angiogenesis negative regulation of monocyte chemotaxis uc008lpp.1 uc008lpp.2 uc008lpp.3 uc008lpp.4 
ENSMUST00000099589.4 Chrm5 ENSMUST00000099589.4 cholinergic receptor, muscarinic 5 (from RefSeq NM_205783.3) A2AHU3 ACM5_MOUSE ENSMUST00000099589.1 ENSMUST00000099589.2 ENSMUST00000099589.3 NM_205783 Q0VBI9 Q920H4 uc008lpd.1 uc008lpd.2 uc008lpd.3 uc008lpd.4 The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily. gastric acid secretion G-protein coupled receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway chemical synaptic transmission dopamine transport membrane integral component of membrane G-protein coupled acetylcholine receptor activity extracellular-glycine-gated chloride channel activity transmission of nerve impulse cell junction dendrite neurotransmitter receptor activity synapse postsynaptic membrane excitatory postsynaptic potential regulation of phosphatidylinositol dephosphorylation chloride transmembrane transport uc008lpd.1 uc008lpd.2 uc008lpd.3 uc008lpd.4 
ENSMUST00000099596.2 Or4f14d ENSMUST00000099596.2 olfactory receptor family 4 subfamily F member 14D (from RefSeq NM_146742.2) ENSMUST00000099596.1 NM_146742 Olfr1316 Or4f14d Q8VG12 Q8VG12_MOUSE uc008lol.1 uc008lol.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008lol.1 uc008lol.2 
ENSMUST00000099604.6 Or4f14b ENSMUST00000099604.6 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQX1) ENSMUST00000099604.1 ENSMUST00000099604.2 ENSMUST00000099604.3 ENSMUST00000099604.4 ENSMUST00000099604.5 Olfr1307 Olfr1309 Or4f14b Q7TQX1 Q7TQX1_MOUSE uc289zge.1 uc289zge.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zge.1 uc289zge.2 
ENSMUST00000099618.2 Or4k38 ENSMUST00000099618.2 olfactory receptor family 4 subfamily K member 38 (from RefSeq NM_146907.2) ENSMUST00000099618.1 NM_146907 Olfr1282 Olfr1287 Or4k38 Q7TQY5 Q7TQY5_MOUSE uc008lnj.1 uc008lnj.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008lnj.1 uc008lnj.2 
ENSMUST00000099623.10 Ano3 ENSMUST00000099623.10 anoctamin 3, transcript variant 3 (from RefSeq NM_001355245.1) A2AHL0 A2AHL1 ANO3_MOUSE Ano3 ENSMUST00000099623.1 ENSMUST00000099623.2 ENSMUST00000099623.3 ENSMUST00000099623.4 ENSMUST00000099623.5 ENSMUST00000099623.6 ENSMUST00000099623.7 ENSMUST00000099623.8 ENSMUST00000099623.9 NM_001355245 Tmem16c uc012caw.1 uc012caw.2 uc012caw.3 uc012caw.4 Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:23532839). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (PubMed:23872594). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38573; Evidence=; Reaction=a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in); Xref=Rhea:RHEA:38899, ChEBI:CHEBI:18390; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38900; Evidence=; Interacts with KCNT1/Slack. Cell membrane ; Multi-pass membrane protein Note=Shows an intracellular localization. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AHL1-1; Sequence=Displayed; Name=2; IsoId=A2AHL1-2; Sequence=VSP_052958, VSP_052959; Predominantly expressed in neuronal tissues. Expressed in brain. In the developing gastrointestinal tract, expressed in the intestinal epithelium at 14.5 dpc and in an incomplete ring of cells in the mesenchyme of the esophagus, stomach and small intestine at 16.5 dpc. In the developing skeleton, expressed in the perichondria of the neural arch of developing vertebrae at 14.5 dpc and 16.5 dpc. At 14.5 dpc, also expressed in perichondria of developing ribs. At 14.5 dpc and 16.5 dpc, detected in dorsal root ganglia and neural tube. In developing skin, expression is detected in the most suprabasal layers at 16.5 dpc. Not detected in the lung at 14.5 dpc or 16.5 dpc. The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. Belongs to the anoctamin family. cellular_component plasma membrane lipid transport membrane integral component of membrane detection of temperature stimulus phospholipid scramblase activity protein dimerization activity detection of mechanical stimulus calcium activated phospholipid scrambling calcium activated phosphatidylcholine scrambling calcium activated galactosylceramide scrambling uc012caw.1 uc012caw.2 uc012caw.3 uc012caw.4 
ENSMUST00000099626.5 Fibin ENSMUST00000099626.5 fin bud initiation factor homolog (zebrafish) (from RefSeq NM_026271.1) ENSMUST00000099626.1 ENSMUST00000099626.2 ENSMUST00000099626.3 ENSMUST00000099626.4 FIBIN_MOUSE NM_026271 Q9CQS3 uc008lmv.1 uc008lmv.2 uc008lmv.3 Homodimer; disulfide-linked. Seems to also exist as monomers (By similarity). Secreted Golgi apparatus Endoplasmic reticulum At 9.5 dpc and 10.5 dpc, abundantly expressed in the forelimb buds. Belongs to the FIBIN family. extracellular region endoplasmic reticulum Golgi apparatus biological_process response to manganese ion protein homodimerization activity protein kinase C signaling response to dexamethasone uc008lmv.1 uc008lmv.2 uc008lmv.3 
ENSMUST00000099659.3 Pin1rt1 ENSMUST00000099659.3 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1, retrogene 1 (from RefSeq NM_001033768.2) ENSMUST00000099659.1 ENSMUST00000099659.2 NM_001033768 OTTMUSG00000014964 Pin1-ps1 Pin1l Pin1rt1 Q3ULQ2 Q3ULQ2_MOUSE uc008lkd.1 uc008lkd.2 uc008lkd.3 Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence= protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity nucleus cytosol isomerase activity uc008lkd.1 uc008lkd.2 uc008lkd.3 
ENSMUST00000099661.3 Gm10797 ENSMUST00000099661.3 Gm10797 (from geneSymbol) ENSMUST00000099661.1 ENSMUST00000099661.2 LF198051 uc287rwb.1 uc287rwb.2 uc287rwb.1 uc287rwb.2 
ENSMUST00000099663.3 Ftdc1 ENSMUST00000099663.3 ferritin domain containing 1 (from RefSeq NM_001033404.2) ENSMUST00000099663.1 ENSMUST00000099663.2 Ftdc1 Gm813 NM_001033404 Q3UWK9 Q3UWK9_MOUSE uc007znx.1 uc007znx.2 uc007znx.3 Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. ferroxidase activity iron ion binding cytoplasm iron ion transport cellular iron ion homeostasis intracellular sequestering of iron ion ferrous iron binding ferric iron binding identical protein binding metal ion binding oxidation-reduction process uc007znx.1 uc007znx.2 uc007znx.3 
ENSMUST00000099673.9 Cd44 ENSMUST00000099673.9 CD44 antigen, transcript variant 3 (from RefSeq NM_001039151.1) Cd44 ENSMUST00000099673.1 ENSMUST00000099673.2 ENSMUST00000099673.3 ENSMUST00000099673.4 ENSMUST00000099673.5 ENSMUST00000099673.6 ENSMUST00000099673.7 ENSMUST00000099673.8 NM_001039151 Q3U8S1 Q3U8S1_MOUSE uc008lig.1 uc008lig.2 uc008lig.3 uc008lig.4 uc008lig.5 Cell membrane ; Single-pass type I membrane protein Cell projection, microvillus Membrane ; Single-pass type I membrane protein Secreted Lacks conserved residue(s) required for the propagation of feature annotation. hyaluronic acid binding cell adhesion membrane integral component of membrane uc008lig.1 uc008lig.2 uc008lig.3 uc008lig.4 uc008lig.5 
ENSMUST00000099678.5 Fjx1 ENSMUST00000099678.5 four jointed box 1 (from RefSeq NM_010218.2) ENSMUST00000099678.1 ENSMUST00000099678.2 ENSMUST00000099678.3 ENSMUST00000099678.4 FJX1_MOUSE NM_010218 Q8BQB4 Q9Z1M1 uc008lhw.1 uc008lhw.2 uc008lhw.3 Acts as an inhibitor of dendrite extension and branching. Secreted Expressed in brain, kidney and lung. In the telencephalon, expressed in the piriform cortex, hippocampus and olfactory bulb. In the diencephalon, expressed in the dorsal thalamus. Expressed in Purkinje cells of the cerebellum and in numerous medullary nuclei. Expressed in embryo at 8.5 dpc onward. In the neural plate, expressed in the presumptive forebrain and midbrain and in rhombomere at 4 and 8.5 dpc. Expressed in the limb buds and in the ectoderm of the first branchial arches at 9.5 dpc. In the brain, expressed in the dorsal mesencephalon (tectum) and prosencephalon (presumptive isocortex) at 9.5, 10.5 and 11.5 dpc. In the cortex, expressed in dorsolateral patch of the neuroepithelium at 10.5 dpc. Expressed in the ectoderm of the branchial arch and the oral ectoderm at 10.5 dpc. In the limbs, expressed in the apical ectodermal ridge at 11.5 dpc. Expressed in the telecephalon, ventricles, diencephalon and medulla oblongata at 12.5 dpc. Expressed in the neural tube, cochlear ganglion and olfactory bulb at 14.5 dpc. In the kidney, lung and intestine, expressed in epithelial cells at 14.5 dpc. Up-regulated by Notch. Glycosylated. Undergoes proteolytic cleavage. Knockout mice for this gene exhibited an increase in dendrite extension and branching of pyramidal neurons in the CA1 region of the hippocampus. Belongs to the FJX1/FJ family. Sequence=CAA08764.1; Type=Frameshift; Evidence=; extracellular region extracellular space cell-cell signaling retina layer formation uc008lhw.1 uc008lhw.2 uc008lhw.3 
ENSMUST00000099690.4 Accsl ENSMUST00000099690.4 1-aminocyclopropane-1-carboxylate synthase (inactive)-like, transcript variant 1 (from RefSeq NM_001033452.4) 1A1L2_MOUSE ENSMUST00000099690.1 ENSMUST00000099690.2 ENSMUST00000099690.3 Gm1967 NM_001033452 Q3TQ30 Q3UX83 uc008lgl.1 uc008lgl.2 uc008lgl.3 uc008lgl.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UX83-1; Sequence=Displayed; Name=2; IsoId=Q3UX83-2; Sequence=VSP_033860; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. While belonging to the class-I pyridoxal-phosphate-dependent aminotransferase family, it lacks a number of residues which are necessary for activity thus suggesting that it lacks enzymatic activity. catalytic activity cellular_component biological_process biosynthetic process pyridoxal phosphate binding uc008lgl.1 uc008lgl.2 uc008lgl.3 uc008lgl.4 
ENSMUST00000099691.11 Hk1 ENSMUST00000099691.11 hexokinase 1, transcript variant 1 (from RefSeq NM_001146100.1) ENSMUST00000099691.1 ENSMUST00000099691.10 ENSMUST00000099691.2 ENSMUST00000099691.3 ENSMUST00000099691.4 ENSMUST00000099691.5 ENSMUST00000099691.6 ENSMUST00000099691.7 ENSMUST00000099691.8 ENSMUST00000099691.9 Hk1 NM_001146100 Q6GQU1 Q6GQU1_MOUSE uc007fgy.1 uc007fgy.2 uc007fgy.3 uc007fgy.4 Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+); Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826; Evidence=; Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+); Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741; Evidence=; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 1/4. Carbohydrate metabolism; hexose metabolism. Belongs to the hexokinase family. nucleotide binding cellular glucose homeostasis hexokinase activity ATP binding glucose binding cell carbohydrate metabolic process glycolytic process kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor carbohydrate phosphorylation uc007fgy.1 uc007fgy.2 uc007fgy.3 uc007fgy.4 
ENSMUST00000099697.3 Slc17a2 ENSMUST00000099697.3 solute carrier family 17 (sodium phosphate), member 2, transcript variant 1 (from RefSeq NM_001377113.1) ENSMUST00000099697.1 ENSMUST00000099697.2 NM_001377113 NPT3_MOUSE Npt3 Q5SZA1 Q8VCX8 uc288lmp.1 uc288lmp.2 Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions (PubMed:25972451). Mediates chloride-dependent transport of urate (PubMed:25972451). Can actively transport inorganic phosphate into cells via Na(+) cotransport (PubMed:25972451). Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in); Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; Evidence=; Reaction=n chloride(in) + urate(out) = n chloride(out) + urate(in); Xref=Rhea:RHEA:72319, ChEBI:CHEBI:17775, ChEBI:CHEBI:17996; Evidence=; Kinetic parameters: KM=0.5 mM for urate ; Vmax=43.7 nmol/min/mg protein for urate ; Apical cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SZA1-1; Sequence=Displayed; Name=2; IsoId=Q5SZA1-2; Sequence=VSP_020639; Expressed in the liver, kidney, placenta, lung and thyroid (at protein level). Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. integral component of plasma membrane ion transport sodium ion transport symporter activity membrane integral component of membrane transmembrane transport uc288lmp.1 uc288lmp.2 
ENSMUST00000099703.5 H2bc3 ENSMUST00000099703.5 H2B clustered histone 3 (from RefSeq NM_175664.3) ENSMUST00000099703.1 ENSMUST00000099703.2 ENSMUST00000099703.3 ENSMUST00000099703.4 H2B1B_MOUSE H2bc3 Hist1h2bb NM_175664 Q14AF8 Q64475 uc007pus.1 uc007pus.2 uc007pus.3 uc007pus.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome DNA binding nucleus nucleoplasm chromosome cytosol nucleosome assembly protein heterodimerization activity uc007pus.1 uc007pus.2 uc007pus.3 uc007pus.4 
ENSMUST00000099705.5 Nxpe3 ENSMUST00000099705.5 neurexophilin and PC-esterase domain family, member 3 (from RefSeq NM_001134457.1) B9EKK6 B9EKK6_MOUSE ENSMUST00000099705.1 ENSMUST00000099705.2 ENSMUST00000099705.3 ENSMUST00000099705.4 Fam55c NM_001134457 Nxpe3 uc007zlq.1 uc007zlq.2 uc007zlq.3 uc007zlq.4 uc007zlq.5 Belongs to the NXPE family. molecular_function cellular_component biological_process membrane integral component of membrane uc007zlq.1 uc007zlq.2 uc007zlq.3 uc007zlq.4 uc007zlq.5 
ENSMUST00000099714.10 Zfp408 ENSMUST00000099714.10 zinc finger protein 408, transcript variant 12 (from RefSeq NM_001410217.1) ENSMUST00000099714.1 ENSMUST00000099714.2 ENSMUST00000099714.3 ENSMUST00000099714.4 ENSMUST00000099714.5 ENSMUST00000099714.6 ENSMUST00000099714.7 ENSMUST00000099714.8 ENSMUST00000099714.9 H7BX78 H7BX78_MOUSE NM_001410217 Zfp408 uc057ldo.1 uc057ldo.2 uc057ldo.3 nucleic acid binding nucleus biological_process identical protein binding uc057ldo.1 uc057ldo.2 uc057ldo.3 
ENSMUST00000099726.5 Duxf4 ENSMUST00000099726.5 double homeobox family member 4 (from RefSeq NM_001034869.2) EG245263 ENSMUST00000099726.1 ENSMUST00000099726.2 ENSMUST00000099726.3 ENSMUST00000099726.4 Gm4981 NM_001034869 Q3ULJ8 Q3ULJ8_MOUSE uc007fcw.1 uc007fcw.2 uc007fcw.3 Nucleus DNA binding cellular_component nucleus biological_process uc007fcw.1 uc007fcw.2 uc007fcw.3 
ENSMUST00000099735.6 Yae1d1 ENSMUST00000099735.6 Yae1 domain containing 1 (from RefSeq NM_025904.3) 1600012F09Rik ENSMUST00000099735.1 ENSMUST00000099735.2 ENSMUST00000099735.3 ENSMUST00000099735.4 ENSMUST00000099735.5 NM_025904 Q9DAY6 Q9DAY6_MOUSE Yae1d1 uc007pog.1 uc007pog.2 uc007pog.3 uc007pog.4 Cytoplasm Nucleus molecular_function cellular_component uc007pog.1 uc007pog.2 uc007pog.3 uc007pog.4 
ENSMUST00000099739.5 Tbc1d32 ENSMUST00000099739.5 TBC1 domain family, member 32 (from RefSeq NM_001033385.3) BROMI_MOUSE Bromi ENSMUST00000099739.1 ENSMUST00000099739.2 ENSMUST00000099739.3 ENSMUST00000099739.4 NM_001033385 Q3URV1 uc007fca.1 uc007fca.2 uc007fca.3 Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling. Interacts with CDK20, which promotes CDK20 stability and function (PubMed:20159594). Interacts with FAM149B1; may play a role in cilium assembly. Cytoplasm Cell projection, cilium Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3URV1-1; Sequence=Displayed; Name=2; IsoId=Q3URV1-2; Sequence=VSP_039021; Present at 10.5 dpc (at protein level). Mice exhibit exencephaly, poorly developed eyes and preaxial polydactyly, due to defects in ventral patterning. The Rab-GAP TBC domain appears to be inactive, probably due to a lack of the essential Arg and Gln in the catalytic finger motifs. Sequence=BAE24586.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; lens development in camera-type eye retinal pigment epithelium development protein binding cellular_component cytoplasm cilium smoothened signaling pathway multicellular organism development determination of left/right symmetry heart development neural tube development axoneme assembly embryonic digit morphogenesis cell projection camera-type eye development retina development in camera-type eye cilium assembly smoothened signaling pathway involved in dorsal/ventral neural tube patterning protein localization to cilium non-motile cilium assembly uc007fca.1 uc007fca.2 uc007fca.3 
ENSMUST00000099742.9 Cfap44 ENSMUST00000099742.9 cilia and flagella associated protein 44 (from RefSeq NM_001033247.1) CFA44_MOUSE Cfap44 E9Q5M6 ENSMUST00000099742.1 ENSMUST00000099742.2 ENSMUST00000099742.3 ENSMUST00000099742.4 ENSMUST00000099742.5 ENSMUST00000099742.6 ENSMUST00000099742.7 ENSMUST00000099742.8 NM_001033247 uc012agb.1 uc012agb.2 Flagellar protein involved in sperm flagellum axoneme organization and function. Cell projection, cilium, flagellum Cytoplasm, cytoskeleton, flagellum axoneme Expressed in testis. Mice are viable and show no malformations. However, homozygous males exhibit complete male sterility due to severe defects in sperm mobility. Sperm from mutant mice is characterized by normal flagellum length, but most of them showed abnormal forms and irregular caliber of the midpiece. Females are fertile and give litters of normal size. Belongs to the CFAP44 family. cytoplasm cytoskeleton cilium axoneme sperm axoneme assembly flagellated sperm motility motile cilium cell projection cilium assembly uc012agb.1 uc012agb.2 
ENSMUST00000099747.5 B3galnt2 ENSMUST00000099747.5 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2, transcript variant 1 (from RefSeq NM_178640.3) B3GL2_MOUSE ENSMUST00000099747.1 ENSMUST00000099747.2 ENSMUST00000099747.3 ENSMUST00000099747.4 NM_178640 Q5U4F9 Q8BG28 Q8BXL0 uc007pmn.1 uc007pmn.2 uc007pmn.3 Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O- glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O- mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4- (phosphate-6-)mannose), a carbohydrate structure present in alpha- dystroglycan, which is required for binding laminin G-like domain- containing extracellular proteins with high affinity (By similarity). Reaction=3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L- threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[beta- D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP; Xref=Rhea:RHEA:37667, Rhea:RHEA-COMP:13308, Rhea:RHEA- COMP:13618, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:136709, ChEBI:CHEBI:137540; EC=2.4.1.313; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Endoplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BG28-1; Sequence=Displayed; Name=2; IsoId=Q8BG28-2; Sequence=VSP_020253, VSP_020254; Present in testis (at protein level). In testis, it is mainly detected in the middle layers of seminiferous tubules at stages XII to II. Strongly expressed in primary and secondary spermatocytes and early round spermatids, but not in spermatogonia, elongating or elongated spermatids, or in Leydig or Sertoli cells. N-glycosylated. Belongs to the glycosyltransferase 31 family. Golgi membrane endoplasmic reticulum Golgi apparatus protein glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups UDP-N-acetylgalactosamine metabolic process uc007pmn.1 uc007pmn.2 uc007pmn.3 
ENSMUST00000099761.10 Lsamp ENSMUST00000099761.10 limbic system-associated membrane protein, transcript variant 2 (from RefSeq NM_001347236.2) ENSMUST00000099761.1 ENSMUST00000099761.2 ENSMUST00000099761.3 ENSMUST00000099761.4 ENSMUST00000099761.5 ENSMUST00000099761.6 ENSMUST00000099761.7 ENSMUST00000099761.8 ENSMUST00000099761.9 Lsamp NM_001347236 Q3TYE5 Q3TYE5_MOUSE uc007zfu.1 uc007zfu.2 uc007zfu.3 Cell membrane ; Lipid-anchor, GPI-anchor Membrane ; Lipid-anchor, GPI-anchor Belongs to the immunoglobulin superfamily. IgLON family. cytosol membrane integral component of membrane uc007zfu.1 uc007zfu.2 uc007zfu.3 
ENSMUST00000099787.2 Or4c123 ENSMUST00000099787.2 olfactory receptor family 4 subfamily C member 123 (from RefSeq NM_146789.1) ENSMUST00000099787.1 NM_146789 Olfr1230 Or4c123 Q8VG58 Q8VG58_MOUSE uc008krf.1 uc008krf.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC108937.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008krf.1 uc008krf.2 
ENSMUST00000099793.3 Or4c119 ENSMUST00000099793.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A3KGY4) A0A140T8L8 A3KGY4 A3KGY4_MOUSE ENSMUST00000099793.1 ENSMUST00000099793.2 Olfr1224 Or4c119 uc289ybf.1 uc289ybf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ybf.1 uc289ybf.2 
ENSMUST00000099805.3 Prl2c3 ENSMUST00000099805.3 prolactin family 2, subfamily c, member 3 (from RefSeq NM_011118.2) ENSMUST00000099805.1 ENSMUST00000099805.2 Mrp2 Mrp3 Mrpplf3 NM_011118 P04768 P18918 PR2C3_MOUSE Plf2 Plf3 Prl2c4 Q498A5 Q6PDB6 uc007plw.1 uc007plw.2 uc007plw.3 uc007plw.4 uc007plw.5 uc007plw.6 May have a role in embryonic development. It is likely to provide a growth stimulus to target cells in maternal and fetal tissues during the development of the embryo at mid-gestation. May play a role during wound healing and in the hair follicle cycle as a growth factor and/or an angiogenesis factor. May play a role in microvilli formation and cell proliferation of neuroblastoma cells. Secreted doplasmic reticulum Expressed in placenta and hair follicles, with highest expression levels detected in the outer root sheath and no expression detected in bulb (PubMed:11316781). Expressed in placenta, skin wounds, keratinocytes and weakly in embryonic fibroblasts (PubMed:10537154, PubMed:11316781, PubMed:16876275). Expressed in brain, cerebellum and in Neuro-2a cell line (PubMed:16876275). Not detected in liver, kidney, ovary, pituitary gland and brain (PubMed:3859868). Expressed during hair follicle morphogenesis, with highest expression levels detected at late anagen stage of the hair follicle cycle (PubMed:11316781). Expressed in developing brain from embryo to adult (PubMed:16876275). In placenta, detected at 8 dpc, peaks at 10 dpc and declines thereafter (PubMed:10537154). N-glycosylated and sialylated. Belongs to the somatotropin/prolactin family. Prl2c3 and Prl2c4 have previously been regarded as different proteins, but they seem to be products of the same gene. prolactin receptor binding hormone activity extracellular region extracellular space endoplasmic reticulum signal transduction female pregnancy growth factor activity positive regulation of cell proliferation mammary gland development response to nutrient levels positive regulation of JAK-STAT cascade positive regulation of lactation uc007plw.1 uc007plw.2 uc007plw.3 uc007plw.4 uc007plw.5 uc007plw.6 
ENSMUST00000099830.3 Or5d43 ENSMUST00000099830.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR24) ENSMUST00000099830.1 ENSMUST00000099830.2 Olfr1173 Or5d43 Q7TR24 Q7TR24_MOUSE uc289xxu.1 uc289xxu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxu.1 uc289xxu.2 
ENSMUST00000099834.5 Or5d37 ENSMUST00000099834.5 olfactory receptor family 5 subfamily D member 37 (from RefSeq NM_146641.2) A2AVT5 A2AVT5_MOUSE ENSMUST00000099834.1 ENSMUST00000099834.2 ENSMUST00000099834.3 ENSMUST00000099834.4 NM_146641 Olfr1164 Or5d37 uc008kpi.1 uc008kpi.2 uc008kpi.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC132589.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kpi.1 uc008kpi.2 uc008kpi.3 
ENSMUST00000099840.2 Or5d47 ENSMUST00000099840.2 olfactory receptor family 5 subfamily D member 47 (from RefSeq NM_054091.2) A2BHP6 A2BHP6_MOUSE ENSMUST00000099840.1 NM_054091 Olfr74 Or5d47 uc008kpb.1 uc008kpb.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: AB061229.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kpb.1 uc008kpb.2 
ENSMUST00000099841.4 Or5l14 ENSMUST00000099841.4 olfactory receptor family 5 subfamily L member 14 (from RefSeq NM_146849.2) A2AVC4 A2AVC4_MOUSE ENSMUST00000099841.1 ENSMUST00000099841.2 ENSMUST00000099841.3 NM_146849 Olfr1157 Or5l14 uc008kpa.1 uc008kpa.2 uc008kpa.3 uc008kpa.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DR065606.1, CB173223.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kpa.1 uc008kpa.2 uc008kpa.3 uc008kpa.4 
ENSMUST00000099846.2 Or5w17 ENSMUST00000099846.2 olfactory receptor 1141 (from RefSeq NM_146637.1) ENSMUST00000099846.1 NM_146637 Olfr1141 Or5w17 Q8VFQ7 Q8VFQ7_MOUSE uc008kop.1 uc008kop.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein olfactory receptor activity odorant binding signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane detection of chemical stimulus involved in sensory perception of smell uc008kop.1 uc008kop.2 
ENSMUST00000099856.6 Mtr ENSMUST00000099856.6 5-methyltetrahydrofolate-homocysteine methyltransferase (from RefSeq NM_001081128.3) A6H5Y3 ENSMUST00000099856.1 ENSMUST00000099856.2 ENSMUST00000099856.3 ENSMUST00000099856.4 ENSMUST00000099856.5 METH_MOUSE Mtr NM_001081128 Q3UQP2 uc007plh.1 uc007plh.2 uc007plh.3 uc007plh.4 uc007plh.5 Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Reaction=(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine; Xref=Rhea:RHEA:11172, ChEBI:CHEBI:18608, ChEBI:CHEBI:57453, ChEBI:CHEBI:57844, ChEBI:CHEBI:58199; EC=2.1.1.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11173; Evidence=; Name=methylcob(III)alamin; Xref=ChEBI:CHEBI:28115; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1. Monomer. Dimer. Forms a multiprotein complex with MMACHC, MMADHC and MTRR. Cytoplasm Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin (By similarity). Belongs to the vitamin-B12 dependent methionine synthase family. folic acid binding cytoplasm cytosol protein methylation methionine metabolic process methyltransferase activity zinc ion binding cellular amino acid biosynthetic process methionine synthase activity methionine biosynthetic process cobalamin metabolic process amino acid binding transferase activity axon regeneration cobalamin binding methylation pteridine-containing compound metabolic process cellular metabolic process tetrahydrofolate metabolic process metal ion binding response to axon injury homocysteine metabolic process cellular response to nitric oxide uc007plh.1 uc007plh.2 uc007plh.3 uc007plh.4 uc007plh.5 
ENSMUST00000099858.4 Prep ENSMUST00000099858.4 prolyl endopeptidase (from RefSeq NM_011156.3) ENSMUST00000099858.1 ENSMUST00000099858.2 ENSMUST00000099858.3 NM_011156 PPCE_MOUSE Pep Q80YS1 Q9QUR6 uc007ezx.1 uc007ezx.2 uc007ezx.3 Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.; EC=3.4.21.26; Cytoplasm. Belongs to the peptidase S9A family. endopeptidase activity serine-type endopeptidase activity nucleus cytoplasm cytosol proteolysis peptidase activity serine-type peptidase activity hydrolase activity protein metabolic process peptide binding serine-type exopeptidase activity oligopeptidase activity uc007ezx.1 uc007ezx.2 uc007ezx.3 
ENSMUST00000099874.2 Or5t15 ENSMUST00000099874.2 olfactory receptor family 5 subfamily T member 15 (from RefSeq NM_146730.2) A3KPP5 A3KPP7 A3KPP7_MOUSE ENSMUST00000099874.1 NM_146730 Olfr1095 Olfr141 Or5t15 uc008kna.1 uc008kna.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This sequence is assembled by in silico methods with additional support of similarity to mouse olfactory receptors. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kna.1 uc008kna.2 
ENSMUST00000099882.2 Or8k32 ENSMUST00000099882.2 olfactory receptor family 8 subfamily K member 32 (from RefSeq NM_146407.1) ENSMUST00000099882.1 NM_146407 Olfr1079 Or8k32 Q8VF52 Q8VF52_MOUSE uc008kmn.1 uc008kmn.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kmn.1 uc008kmn.2 
ENSMUST00000099885.2 Or8k28 ENSMUST00000099885.2 olfactory receptor family 8 subfamily K member 28 (from RefSeq NM_001011735.2) A2AK62 A2AK62_MOUSE ENSMUST00000099885.1 NM_001011735 Olfr1066 Or8k28 uc008kmk.1 uc008kmk.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kmk.1 uc008kmk.2 
ENSMUST00000099889.2 Or8k25 ENSMUST00000099889.2 olfactory receptor family 8 subfamily K member 25 (from RefSeq NM_207134.1) ENSMUST00000099889.1 NM_207134 Olfr1061 Or8k25 Q7TR72 Q7TR72_MOUSE uc008kmh.1 uc008kmh.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kmh.1 uc008kmh.2 
ENSMUST00000099897.5 Or8k21 ENSMUST00000099897.5 olfactory receptor family 8 subfamily K member 21 (from RefSeq NM_001177857.1) ENSMUST00000099897.1 ENSMUST00000099897.2 ENSMUST00000099897.3 ENSMUST00000099897.4 L7MU59 L7MU59_MOUSE NM_001177857 Olfr1053 Or8k21 uc012bys.1 uc012bys.2 uc012bys.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc012bys.1 uc012bys.2 uc012bys.3 
ENSMUST00000099909.2 Or5al6 ENSMUST00000099909.2 olfactory receptor family 5 subfamily AL member 6 (from RefSeq NM_207561.2) A2ARY1 A2ARY1_MOUSE ENSMUST00000099909.1 NM_207561 Olfr1040 Or5al6 uc008klq.1 uc008klq.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008klq.1 uc008klq.2 
ENSMUST00000099912.2 Or5m12 ENSMUST00000099912.2 olfactory receptor family 5 subfamily M member 12 (from RefSeq NM_001005230.2) A2ASU7 A2ASU7_MOUSE ENSMUST00000099912.1 NM_001005230 Olfr1024 Or5m12 uc008kld.1 uc008kld.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC119447.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kld.1 uc008kld.2 
ENSMUST00000099917.4 Or9g4 ENSMUST00000099917.4 olfactory receptor family 9 subfamily G member 4 (from RefSeq NM_146570.2) A2ALD2 A2ALD2_MOUSE E9PXR8 ENSMUST00000099917.1 ENSMUST00000099917.2 ENSMUST00000099917.3 NM_146570 Olfr1006 Or9g4 uc008kkp.1 uc008kkp.2 uc008kkp.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB173872.1, DR065595.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kkp.1 uc008kkp.2 uc008kkp.3 
ENSMUST00000099918.5 Or5g26 ENSMUST00000099918.5 olfactory receptor family 5 subfamily G member 26 (from RefSeq NM_013728.2) A2ALD1 ENSMUST00000099918.1 ENSMUST00000099918.2 ENSMUST00000099918.3 ENSMUST00000099918.4 Mor175-1 NM_013728 O5G26_MOUSE Olfr154 Olfr4-3 Or5g26 Or912-93 Or93 Q0VBG5 Q9QY00 uc008kko.1 uc008kko.2 uc008kko.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC120642.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kko.1 uc008kko.2 uc008kko.3 
ENSMUST00000099923.2 Fads2b ENSMUST00000099923.2 fatty acid desaturase 2B (from RefSeq NM_001081664.2) ENSMUST00000099923.1 FS2P1_MOUSE Fads2b NM_001081664 Q0VAX3 uc008kkj.1 uc008kkj.2 uc008kkj.3 Lipid metabolism; polyunsaturated fatty acid biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein The histidine box domains may contain the active site and/or be involved in metal ion binding. Belongs to the fatty acid desaturase type 1 family. cellular_component endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process biological_process membrane integral component of membrane oxidoreductase activity metal ion binding oxidation-reduction process uc008kkj.1 uc008kkj.2 uc008kkj.3 
ENSMUST00000099926.2 Or5ak23 ENSMUST00000099926.2 olfactory receptor family 5 subfamily AK member 23 (from RefSeq NM_146435.1) ENSMUST00000099926.1 NM_146435 Olfr993 Or5ak23 Q8VF75 Q8VF75_MOUSE uc008kkg.1 uc008kkg.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kkg.1 uc008kkg.2 
ENSMUST00000099930.9 Lrrc55 ENSMUST00000099930.9 Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. (from UniProt A0A3B2WBQ3) A0A3B2WBQ3 A0A3B2WBQ3_MOUSE AK134968 ENSMUST00000099930.1 ENSMUST00000099930.2 ENSMUST00000099930.3 ENSMUST00000099930.4 ENSMUST00000099930.5 ENSMUST00000099930.6 ENSMUST00000099930.7 ENSMUST00000099930.8 Lrrc55 uc012byq.1 uc012byq.2 uc012byq.3 Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. Interacts with KCNMA1. membrane integral component of membrane uc012byq.1 uc012byq.2 uc012byq.3 
ENSMUST00000099946.6 Net1 ENSMUST00000099946.6 neuroepithelial cell transforming gene 1, transcript variant 2 (from RefSeq NM_001047159.2) ARHG8_MOUSE Arhgef8 ENSMUST00000099946.1 ENSMUST00000099946.2 ENSMUST00000099946.3 ENSMUST00000099946.4 ENSMUST00000099946.5 NM_001047159 Q8C4I0 Q9Z1L7 Q9Z206 uc007pjd.1 uc007pjd.2 uc007pjd.3 uc007pjd.4 uc007pjd.5 Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway. Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. Interacts with RHOA in its GTP- and GDP-bound states, and with CDC42 in its GTP-bound state. Interacts with the PDZ 1 domain of BAIAP1. Q9Z206; Q6RHR9: Magi1; NbExp=6; IntAct=EBI-7840997, EBI-7440897; Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z206-1; Sequence=Displayed; Name=2; Synonyms=Net1a; IsoId=Q9Z206-2; Sequence=VSP_011622, VSP_011623; The PH domain is sufficient for the nuclear export of the oncogenic N-terminal truncated form. The relocalization is not affected by the Leu-492 mutation. Can be converted to an oncogenic protein by N-terminal deletion that leads to nuclear export and cytoplasmic localization. Transformation seems to require the activity of multiple signaling pathways. The physiological conditions for cytoplasmic relocalization are not known yet. guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding nucleus cytoplasm plasma membrane GTP-Rho binding regulation of Rho protein signal transduction intracellular signal transduction positive regulation of apoptotic process positive regulation of GTPase activity myoblast migration cellular response to hydrogen peroxide cellular response to ionizing radiation positive regulation of substrate adhesion-dependent cell spreading uc007pjd.1 uc007pjd.2 uc007pjd.3 uc007pjd.4 uc007pjd.5 
ENSMUST00000099947.3 Cwc22rt6 ENSMUST00000099947.3 Nucleus speckle (from UniProt A2AK42) A2AK42 A2AK42_MOUSE Cwc22rt1 Cwc22rt2 Cwc22rt4 Cwc22rt5 Cwc22rt6 Cwc22rt7 ENSMUST00000099947.1 ENSMUST00000099947.2 uc289xkg.1 uc289xkg.2 Nucleus speckle Belongs to the CWC22 family. mRNA splicing, via spliceosome RNA binding catalytic step 2 spliceosome uc289xkg.1 uc289xkg.2 
ENSMUST00000099948.3 Cwc22rt7 ENSMUST00000099948.3 Nucleus speckle (from UniProt A2AK42) A2AK42 A2AK42_MOUSE Cwc22rt1 Cwc22rt2 Cwc22rt4 Cwc22rt5 Cwc22rt6 Cwc22rt7 ENSMUST00000099948.1 ENSMUST00000099948.2 uc289xke.1 uc289xke.2 Nucleus speckle Belongs to the CWC22 family. mRNA splicing, via spliceosome RNA binding catalytic step 2 spliceosome uc289xke.1 uc289xke.2 
ENSMUST00000099951.3 Cwc22rt3 ENSMUST00000099951.3 Nucleus speckle (from UniProt A2AK44) A2AK44 A2AK44_MOUSE Cwc22rt3 ENSMUST00000099951.1 ENSMUST00000099951.2 Gm13695 uc289xjy.1 uc289xjy.2 Nucleus speckle Belongs to the CWC22 family. mRNA splicing, via spliceosome RNA binding catalytic step 2 spliceosome uc289xjy.1 uc289xjy.2 
ENSMUST00000099955.4 Fam89b ENSMUST00000099955.4 family with sequence similarity 89, member B, transcript variant 1 (from RefSeq NM_181452.2) C184m ENSMUST00000099955.1 ENSMUST00000099955.2 ENSMUST00000099955.3 Fam89b LRA25_MOUSE Lrap25 Mtvr2 NM_181452 Q8K2S5 Q9JHD8 Q9JL54 Q9QUI1 uc008gez.1 uc008gez.2 uc008gez.3 Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:12646588). Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (PubMed:25107909). [Isoform 2]: (Microbial infection) May be a receptor for mouse mammary tumor virus (MMTV). Interacts with SKI (PubMed:12646588). Interacts (via LRR repeat) with CDC42BPA (via AGC-kinase C-terminal domain), CDC42BPB (via AGC-kinase C-terminal domain) and LIMK1 (via LIM zinc-binding domains). Forms a tripartite complex with CDC42BPA, CDC42BPB and LIMK1 (PubMed:25107909). [Isoform 2]: (Microbial infection) Interacts with mouse mammary tumor virus (MMTV) envelope glycoprotein gp70. Q9QUI1; P12755: SKI; Xeno; NbExp=6; IntAct=EBI-6503100, EBI-347281; [Isoform 1]: Cytoplasm Cell projection, lamellipodium Note=Co-localizes with CDC42BPA, CDC42BPB and LIMK1 in the lamellipodium. [Isoform 2]: Cell surface Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=MMTV receptor variant 2; IsoId=Q9QUI1-1; Sequence=Displayed; Name=2; Synonyms=MMTV receptor variant 1; IsoId=Q9QUI1-2; Sequence=VSP_045017; Widely expressed. Expressed in the early postnatal brain. Expressed in forebrain at 16 dpc. Belongs to the FAM89 family. transcription corepressor binding protein binding cytoplasm cell surface establishment of cell polarity lamellipodium positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway cell projection negative regulation of SMAD protein import into nucleus uc008gez.1 uc008gez.2 uc008gez.3 
ENSMUST00000099967.10 Fyn ENSMUST00000099967.10 Fyn proto-oncogene, transcript variant 1 (from RefSeq NM_001122893.1) ENSMUST00000099967.1 ENSMUST00000099967.2 ENSMUST00000099967.3 ENSMUST00000099967.4 ENSMUST00000099967.5 ENSMUST00000099967.6 ENSMUST00000099967.7 ENSMUST00000099967.8 ENSMUST00000099967.9 FYN_MOUSE NM_001122893 P39688 Q3TAT3 Q3U0T5 Q8K2A3 uc007evx.1 uc007evx.2 uc007evx.3 uc007evx.4 uc007evx.5 Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta- catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (PubMed:12681493). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site. Interacts (via its SH3 domain) with PIK3R1 and PRMT8 (By similarity). Interacts with FYB1, PAG1, and SH2D1A (By similarity). Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity (PubMed:8168489). Interacts with TOM1L1 (phosphorylated form) (PubMed:11711534). Interacts with SH2D1A and SLAMF1 (By similarity). Interacts with and phosphorylates ITCH, down- regulating its activity (By similarity). Interacts with FASLG (By similarity). Interacts with RUNX3 (By similarity). Interacts with KIT (By similarity). Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion (By similarity). Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation (By similarity). Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway (By similarity). Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity). Interacts with KDR (tyrosine phosphorylated) (PubMed:16966330). Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (PubMed:7681396, PubMed:9312046). Interacts with UNC119 (By similarity). Interacts (via SH2 domain) with PTPRH (phosphorylated form) (PubMed:20398064). Interacts with PTPRO (phosphorylated form) (PubMed:20398064). Interacts with PTPRB (phosphorylated form) (PubMed:20398064). Interacts with FYB2 (By similarity). Interacts with DSCAM (PubMed:22685302). Interacts with SKAP1 and FYB1; this interaction promotes the phosphorylation of CLNK (PubMed:12681493). Interacts with NEDD9; in the presence of PTK2 (By similarity). P39688; P22682: Cbl; NbExp=5; IntAct=EBI-524514, EBI-640919; P39688; P51807: Dynlt1; NbExp=3; IntAct=EBI-524514, EBI-642797; P39688; Q60749: Khdrbs1; NbExp=15; IntAct=EBI-524514, EBI-519077; P39688; Q9WU01: Khdrbs2; NbExp=2; IntAct=EBI-524514, EBI-8339046; P39688; P05622: Pdgfrb; NbExp=3; IntAct=EBI-524514, EBI-1554855; P39688; Q9QUM4: Slamf1; NbExp=4; IntAct=EBI-524514, EBI-7910086; P39688; Q9JIA7: Sphk2; NbExp=2; IntAct=EBI-524514, EBI-985434; P39688; P22681: CBL; Xeno; NbExp=3; IntAct=EBI-524514, EBI-518228; P39688; Q14332: FZD2; Xeno; NbExp=4; IntAct=EBI-524514, EBI-6254477; P39688; P35570: Irs1; Xeno; NbExp=4; IntAct=EBI-524514, EBI-520230; P39688; O75051: PLXNA2; Xeno; NbExp=3; IntAct=EBI-524514, EBI-308264; P39688; P18433: PTPRA; Xeno; NbExp=2; IntAct=EBI-524514, EBI-2609645; Cytoplasm Nucleus Cell membrane Perikaryon Note=Present and active in lipid rafts (PubMed:14645715). Palmitoylation is crucial for proper trafficking (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=B; IsoId=P39688-1; Sequence=Displayed; Name=2; Synonyms=T; IsoId=P39688-2; Sequence=VSP_024111, VSP_024112; Isoform 1 is highly expressed in the brain, isoform 2 is expressed in cells of hemopoietic lineages, especially T- lymphocytes. Autophosphorylated at Tyr-420 (PubMed:8441403). Phosphorylation on the C-terminal tail at Tyr-531 by CSK maintains the enzyme in an inactive state (PubMed:8441403). PTPRC/CD45 dephosphorylates Tyr-531 leading to activation. Ultraviolet B (UVB) strongly increase phosphorylation at Thr-15 and kinase activity, and promotes translocation from the cytoplasm to the nucleus. Dephosphorylation at Tyr-420 by PTPN2 negatively regulates T-cell receptor signaling (By similarity). Phosphorylated at tyrosine residues, which can be enhanced by NTN1 (PubMed:22685302). Palmitoylated (PubMed:19956733, PubMed:7980442, PubMed:8413237, PubMed:9201723). Palmitoylation at Cys-3 and Cys-6, probably by ZDHHC21, regulates subcellular location (PubMed:7980442, PubMed:8413237, PubMed:9201723, PubMed:19956733). Myristoylation is required prior to palmitoylation. Mice have various neural defects, including defective long term potentiation, impaired spatial memory, hypomyelination, abnormal dendrite orientation and uncoordinated hippocampal structure. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. nucleotide binding response to singlet oxygen G-protein coupled receptor binding neuron migration adaptive immune response immune system process heart process protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding nucleus cytoplasm mitochondrion endosome cytosol actin filament plasma membrane protein phosphorylation cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development regulation of cell shape negative regulation of gene expression negative regulation of hydrogen peroxide biosynthetic process positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase signaling postsynaptic density tubulin binding membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation enzyme binding cell differentiation dendrite forebrain development extrinsic component of cytoplasmic side of plasma membrane negative regulation of protein ubiquitination type 5 metabotropic glutamate receptor binding cellular response to platelet-derived growth factor stimulus peptidyl-tyrosine autophosphorylation regulation of cell proliferation negative regulation of protein catabolic process response to drug positive regulation of tyrosine phosphorylation of STAT protein response to hydrogen peroxide myelination T cell receptor binding CD4 receptor binding CD8 receptor binding identical protein binding alpha-tubulin binding positive regulation of I-kappaB kinase/NF-kappaB signaling intracellular membrane-bounded organelle negative regulation of neuron apoptotic process phosphatidylinositol 3-kinase binding cell body ion channel binding macromolecular complex binding membrane raft response to ethanol protein autophosphorylation metal ion binding ephrin receptor binding tau protein binding perinuclear region of cytoplasm dendrite morphogenesis regulation of peptidyl-tyrosine phosphorylation activated T cell proliferation modulation of synaptic transmission T cell receptor signaling pathway detection of mechanical stimulus involved in sensory perception of pain peptide hormone receptor binding growth factor receptor binding cellular response to growth factor stimulus cellular response to peptide hormone stimulus cellular response to transforming growth factor beta stimulus cell periphery positive regulation of protein targeting to membrane perinuclear endoplasmic reticulum glial cell projection disordered domain specific binding glutamatergic synapse postsynaptic density, intracellular component positive regulation of protein localization to nucleus regulation of glutamate receptor signaling pathway positive regulation of neuron death negative regulation of dendritic spine maintenance negative regulation of oxidative stress-induced cell death response to beta-amyloid cellular response to beta-amyloid cellular response to L-glutamate cellular response to glycine regulation of calcium ion import across plasma membrane positive regulation of cysteine-type endopeptidase activity negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc007evx.1 uc007evx.2 uc007evx.3 uc007evx.4 uc007evx.5 
ENSMUST00000099972.5 Itga4 ENSMUST00000099972.5 integrin alpha 4 (from RefSeq NM_010576.4) ENSMUST00000099972.1 ENSMUST00000099972.2 ENSMUST00000099972.3 ENSMUST00000099972.4 Itga4 NM_010576 Q792F9 Q792F9_MOUSE uc008kgr.1 uc008kgr.2 uc008kgr.3 Membrane ingle-pass type I membrane protein Belongs to the integrin alpha chain family. fibronectin binding positive regulation of leukocyte migration cell-matrix adhesion involved in ameboidal cell migration antigen binding plasma membrane cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion integrin-mediated signaling pathway integrin complex cell surface membrane integral component of membrane C-X3-C chemokine binding growth cone cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading integrin alpha4-beta7 complex endodermal cell differentiation neuronal cell body receptor clustering cell adhesion molecule binding leukocyte tethering or rolling diapedesis axonogenesis involved in innervation extracellular exosome cellular response to cytokine stimulus negative regulation of protein homodimerization activity import into cell positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte tethering or rolling cellular response to beta-amyloid positive regulation of vascular endothelial cell proliferation neuron projection extension protein antigen binding clathrin-dependent extracellular exosome endocytosis positive regulation of endothelial cell apoptotic process positive regulation of T cell migration uc008kgr.1 uc008kgr.2 uc008kgr.3 
ENSMUST00000099981.10 Ttn ENSMUST00000099981.10 titin, transcript variant 3 (from RefSeq NM_001385708.1) A0A5K1VVQ9 A0A5K1VVQ9_MOUSE ENSMUST00000099981.1 ENSMUST00000099981.2 ENSMUST00000099981.3 ENSMUST00000099981.4 ENSMUST00000099981.5 ENSMUST00000099981.6 ENSMUST00000099981.7 ENSMUST00000099981.8 ENSMUST00000099981.9 NM_001385708 Ttn uc289xdq.1 uc289xdq.2 uc289xdq.3 Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. uc289xdq.1 uc289xdq.2 uc289xdq.3 
ENSMUST00000099985.6 Cenpw ENSMUST00000099985.6 centromere protein W (from RefSeq NM_001109747.1) CENPW_MOUSE Cug2 ENSMUST00000099985.1 ENSMUST00000099985.2 ENSMUST00000099985.3 ENSMUST00000099985.4 ENSMUST00000099985.5 NM_001109747 Q3URR0 uc007etd.1 uc007etd.2 uc007etd.3 uc007etd.4 Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis (By similarity). Heterodimer with CENPT; this dimer coassembles with CENPS- CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex, which is a subcomplex of the large constitutive centromere- associated network (CCAN, also known as the interphase centromere complex or ICEN). Interacts with NPM1. Nucleus Chromosome, centromere Chromosome, centromere, kinetochore Nucleus matrix Nucleus, nucleolus Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis. Belongs to the CENP-W/WIP1 family. mitotic cell cycle chromosome, centromeric region kinetochore condensed chromosome kinetochore molecular_function DNA binding nucleus nucleoplasm chromosome nucleolus cell cycle chromosome segregation nuclear matrix protein heterodimerization activity spindle assembly chromosome organization cell division kinetochore assembly uc007etd.1 uc007etd.2 uc007etd.3 uc007etd.4 
ENSMUST00000099986.3 Pjvk ENSMUST00000099986.3 pejvakin (from RefSeq NM_001080711.2) Dfnb59 ENSMUST00000099986.1 ENSMUST00000099986.2 Gm1001 NM_001080711 PJVK_MOUSE Pjvk Q0ZLH2 uc008kfg.1 uc008kfg.2 uc008kfg.3 uc008kfg.4 Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage (PubMed:26544938, PubMed:30936319). Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy) (PubMed:26544938, PubMed:30936319). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss (PubMed:30936319). PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress (PubMed:30936319). In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation (PubMed:26544938, PubMed:30936319). Interacts with MAP1LC3B; interaction is direct (PubMed:30936319). Interacts with IQGAP1 (PubMed:28089576). Interacts with ROCK2 (PubMed:28089576). Interacts with TRIOBP (PubMed:28209736). Peroxisome membrane Cell projection, cilium Note=Associates with the peroxisomal membrane; it is unclear whether it is embedded or just associated with the peroxisomal membrane (PubMed:26544938). Localizes to ciliary rootlet (PubMed:28209736). In ear, it is detected in the organ of Corti and the spiral ganglion within the cochlea in the sensory areas of the vestibule (cristae ampullares of the semicircular ducts, and maculae of the saccule and utricle) and in the first 3 relays (cochlear nuclei, superior olivary complex and inferior colliculus) of the afferent auditory pathway (PubMed:16804542). Detected in hair cells of the cochlea and vestibule but not in neurons (PubMed:17329413, PubMed:28089576). In the afferent auditory pathway, it is present in the cell bodies of neurons but not in fiber bundles such as the trapezoid body in the brainstem (PubMed:16804542). Also detected in spiral ganglion cells, which form the auditory nerve and project to the cochlear nuclei in the brainstem (PubMed:16804542). Also present in the cochlear nuclei, the superior olive and the inferior colliculus (at protein level) (PubMed:16804542). Expressed in all the adult organs tested: brain, eye, inner ear, heart, lung, kidney, liver, intestine, testis and weakly in skeletal muscle (PubMed:16804542). By noise exposure. Mice display progressive hearing loss caused by hypervulnerability to sound exposure (PubMed:17329413, PubMed:26544938). Cochleas display features of marked oxidative stress and impaired antioxidant defenses, and peroxisomes in hair cells show structural abnormalities after the onset of hearing (PubMed:26544938). Mice with conditional deletion in all sensory hair cells show auditory phenotypes with early-onset profound hearing loss and outer hair cell degeneration (PubMed:28089576, PubMed:28209736). Mice with conditional deletion in outer hair cells show auditory phenotypes with early-onset profound hearing loss (PubMed:28089576). Conditional deletion in adult outer hair cells causes a slowly progressive hearing loss associated with outer hair cells degeneration and delayed loss of inner hair cells (PubMed:28089576). Belongs to the gasdermin family. molecular_function sensory perception of sound neuronal cell body uc008kfg.1 uc008kfg.2 uc008kfg.3 uc008kfg.4 
ENSMUST00000099991.11 Nrros ENSMUST00000099991.11 negative regulator of reactive oxygen species, transcript variant 2 (from RefSeq NM_001347181.1) ENSMUST00000099991.1 ENSMUST00000099991.10 ENSMUST00000099991.2 ENSMUST00000099991.3 ENSMUST00000099991.4 ENSMUST00000099991.5 ENSMUST00000099991.6 ENSMUST00000099991.7 ENSMUST00000099991.8 ENSMUST00000099991.9 LRC33_MOUSE Lrrc33 NM_001347181 Nrros Q3TIA8 Q8BMT4 Q8BTT4 Q8BUI7 Q8BY16 Q8R063 uc007yyj.1 uc007yyj.2 uc007yyj.3 Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (PubMed:29909984). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF- beta-1 (PubMed:29909984). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF- beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF- beta-1 by LRRC33/NRROS (PubMed:29909984). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF- kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (Probable). Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1 (PubMed:29909984). Interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 and probably other Toll-like receptors (By similarity). Interacts with CYBB/NOX2; the interaction is direct (PubMed:24739962). Q8BMT4; Q61093: Cybb; NbExp=4; IntAct=EBI-16102695, EBI-6654585; Cell membrane ingle-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BMT4-1; Sequence=Displayed; Name=2; IsoId=Q8BMT4-2; Sequence=VSP_016019; Name=3; IsoId=Q8BMT4-3; Sequence=VSP_016020; Mainly expressed in cells of hematopoietic origin, such as in immune organs such as lymph nodes, thymus and spleen (PubMed:24739962, PubMed:29909984). Among leukocytes, expressed at higher level in myeloid cell such as macrophages, neutrophils and dendritic cells (PubMed:24739962). Highly expressed in central nervous system-resident macrophages, including microglia and perivascular macrophages (PubMed:28459434, PubMed:29909984). Down-regulated by IFN-gamma (IFNG), LPS or TNF-alpha in bone marrow-derived macrophages (BMDMs). N-glycosylated. Mice develop paraparesis and neurodegeneration and display reactive microglia caused by defects in TGF-beta-1 signaling (PubMed:29909984). Mice are viable at six-weeks of age and immune organs and leukocyte subsets are not affected (PubMed:24739962). However, significantly increased reactive oxygen species (ROS) production is observed in primary bone marrow-derived macrophages (BMDMs) upon zymosan stimulation (PubMed:24739962). Mice are more susceptible to Toll-like receptor (TLR) ligand challenges: the macrophages and dendritic cells produce more pro-inflammatory cytokines through increased activation of MAPK and NF-kappa-B (PubMed:24550525). By two months of age, mice begin to display neurological symptoms including defects in motor control and strength and die before six months of age (PubMed:28459434, PubMed:29909984). Mice show microglial development defects (PubMed:28459434, PubMed:29909984). Mice develop progressive paraparesis associated with loss of myelin and axons in the spinal cord and brainstem (PubMed:29909984). Belongs to the LRRC32/LRRC33 family. Was initially thought to act as a negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense (PubMed:24739962). However, these results were based on indirect evidences and could not be confirmed by another group (PubMed:29909984). It was later shown to act as a key regulator of transforming growth factor beta-1 (TGFB1) (PubMed:29909984). Sequence=AAH27411.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC25907.1; Type=Frameshift; Evidence=; Sequence=BAC31275.1; Type=Frameshift; Evidence=; protein binding extracellular region endoplasmic reticulum endoplasmic reticulum membrane plasma membrane superoxide metabolic process inflammatory response immune response transforming growth factor beta receptor signaling pathway cell surface microglia development membrane integral component of membrane growth factor binding ER-associated ubiquitin-dependent protein catabolic process sequestering of TGFbeta in extracellular matrix transforming growth factor beta1 activation transforming growth factor beta binding innate immune response uc007yyj.1 uc007yyj.2 uc007yyj.3 
ENSMUST00000099992.10 Pde11a ENSMUST00000099992.10 phosphodiesterase 11A (from RefSeq NM_001081033.3) A2AKR2 ENSMUST00000099992.1 ENSMUST00000099992.2 ENSMUST00000099992.3 ENSMUST00000099992.4 ENSMUST00000099992.5 ENSMUST00000099992.6 ENSMUST00000099992.7 ENSMUST00000099992.8 ENSMUST00000099992.9 NM_001081033 P0C1Q2 PDE11_MOUSE uc008kex.1 uc008kex.2 uc008kex.3 Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:15800654). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity). Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, ChEBI:CHEBI:58115; EC=3.1.4.35; Evidence=; Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Inhibited by 3-isobutyl-1-methylxanthine (IBMX), zaprinast and dipyridamole. cGMP acts as an allosteric activator (By similarity). Cytoplasm, cytosol Expressed in testis and developing spermatoza. The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP stimulates enzyme activity. Mice live well and have no impaired fertility. They do however display reduced sperm concentration, rate of forward progression and percentage of live spermatozoa. Pre-ejaculated sperm display increased premature/spontaneous capacitance. Belongs to the cyclic nucleotide phosphodiesterase family. catalytic activity cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity cytoplasm cytosol signal transduction phosphoric diester hydrolase activity metabolic process negative regulation of cGMP-mediated signaling hydrolase activity cGMP binding perikaryon negative regulation of cAMP-mediated signaling metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity uc008kex.1 uc008kex.2 uc008kex.3 
ENSMUST00000099994.5 Ift70a1 ENSMUST00000099994.5 intraflagellar transport 70A1 (from RefSeq NM_030188.3) ENSMUST00000099994.1 ENSMUST00000099994.2 ENSMUST00000099994.3 ENSMUST00000099994.4 I70A1_MOUSE NM_030188 Q8C0X1 Q99J38 Ttc30a1 uc289xcy.1 uc289xcy.2 Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. Interacts wit the IFT B complex component IFT52. Cell projection, cilium Belongs to the TTC30/dfy-1/fleer family. centrosome axonemal microtubule cilium cell projection organization intraciliary transport particle B intraciliary anterograde transport ciliary basal body intraciliary transport cell projection uc289xcy.1 uc289xcy.2 
ENSMUST00000099995.5 Ift70a2 ENSMUST00000099995.5 intraflagellar transport 70A2 (from RefSeq NM_001081228.1) A2AKQ8 B2RXQ0 ENSMUST00000099995.1 ENSMUST00000099995.2 ENSMUST00000099995.3 ENSMUST00000099995.4 I70A2_MOUSE NM_001081228 Ttc30a2 uc008kew.1 uc008kew.2 uc008kew.3 uc008kew.4 uc008kew.5 Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. Interacts wit the IFT B complex component IFT52. Cell projection, cilium Belongs to the TTC30/dfy-1/fleer family. axonemal microtubule cilium cell projection organization intraciliary transport particle B ciliary basal body intraciliary transport cell projection uc008kew.1 uc008kew.2 uc008kew.3 uc008kew.4 uc008kew.5 
ENSMUST00000099996.5 Ift70b ENSMUST00000099996.5 intraflagellar transport 70B (from RefSeq NM_028235.1) ENSMUST00000099996.1 ENSMUST00000099996.2 ENSMUST00000099996.3 ENSMUST00000099996.4 IT70B_MOUSE NM_028235 Q3UI02 Q9CY00 Ttc30b uc008keu.1 uc008keu.2 uc008keu.3 uc008keu.4 Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. Interacts with the IFT B complex components IFT27, IFT46, IFT74, IFT52, IFT57, IFT80, IFT81 and IFT88 (PubMed:23810713). Interacts with KIF17 (PubMed:23810713). Cell projection, cilium Belongs to the TTC30/dfy-1/fleer family. axonemal microtubule cilium cell projection organization intraciliary transport particle B ciliary basal body intraciliary transport cell projection uc008keu.1 uc008keu.2 uc008keu.3 uc008keu.4 
ENSMUST00000100000.4 Haglr ENSMUST00000100000.4 Hoxd antisense growth associated long non-coding RNA (from RefSeq NR_110445.1) ENSMUST00000100000.1 ENSMUST00000100000.2 ENSMUST00000100000.3 NR_110445 uc289xay.1 uc289xay.2 uc289xay.3 uc289xay.1 uc289xay.2 uc289xay.3 
ENSMUST00000100013.9 Atp13a3 ENSMUST00000100013.9 ATPase type 13A3, transcript variant 1 (from RefSeq NM_001128096.1) AT133_MOUSE Atp13a3 ENSMUST00000100013.1 ENSMUST00000100013.2 ENSMUST00000100013.3 ENSMUST00000100013.4 ENSMUST00000100013.5 ENSMUST00000100013.6 ENSMUST00000100013.7 ENSMUST00000100013.8 Gm542 NM_001128096 Q5XF89 uc012aee.1 uc012aee.2 uc012aee.3 ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol. Reaction=ATP + H2O + putrescine(out) = ADP + H(+) + phosphate + putrescine(in); Xref=Rhea:RHEA:29995, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:326268, ChEBI:CHEBI:456216; EC=7.6.2.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29996; Evidence=; Recycling endosome membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Note=Mainly targeted to the recycling endosomes and to a lesser extent to the early and late endosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5XF89-1; Sequence=Displayed; Name=2; IsoId=Q5XF89-2; Sequence=VSP_036301; Expression is greatest in liver, followed by kidney, colon, stomach, brain and small intestine. Isoform 1 is highly expressed in the kidney while isoform 2 is highly expressed in the brain. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. nucleotide binding ATP binding cell cation transport cellular calcium ion homeostasis membrane integral component of membrane hydrolase activity ATPase activity metal ion binding uc012aee.1 uc012aee.2 uc012aee.3 
ENSMUST00000100023.3 Mb21d2 ENSMUST00000100023.3 Mab-21 domain containing 2, transcript variant 1 (from RefSeq NM_177718.4) 1600021P15Rik D3Z742 D3Z742_MOUSE ENSMUST00000100023.1 ENSMUST00000100023.2 Mb21d2 NM_177718 uc007yvv.1 uc007yvv.2 uc007yvv.3 Belongs to the mab-21 family. macromolecular complex binding uc007yvv.1 uc007yvv.2 uc007yvv.3 
ENSMUST00000100024.3 Fgf12 ENSMUST00000100024.3 fibroblast growth factor 12, transcript variant 1 (from RefSeq NM_183064.5) ENSMUST00000100024.1 ENSMUST00000100024.2 FGF12_MOUSE Fhf1 NM_183064 O35339 P61329 P70376 Q924B4 Q92912 Q93001 uc007yvr.1 uc007yvr.2 uc007yvr.3 uc007yvr.4 uc007yvr.5 Involved in nervous system development and function. Promote neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. Interacts with the C-terminal region of SCN9A. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P61329-1; Sequence=Displayed; Name=2; IsoId=P61329-2; Sequence=VSP_010223; Belongs to the heparin-binding growth factors family. regulation of membrane depolarization protein binding nucleus JNK cascade chemical synaptic transmission growth factor activity heparin binding adult locomotory behavior positive regulation of sodium ion transport sodium channel regulator activity ion channel binding neuromuscular process regulation of neuronal action potential regulation of sodium ion transmembrane transport regulation of voltage-gated sodium channel activity regulation of sodium ion transmembrane transporter activity negative regulation of cation channel activity fibroblast growth factor receptor binding fibroblast growth factor receptor signaling pathway uc007yvr.1 uc007yvr.2 uc007yvr.3 uc007yvr.4 uc007yvr.5 
ENSMUST00000100026.10 Ccdc50 ENSMUST00000100026.10 coiled-coil domain containing 50, transcript variant 1 (from RefSeq NM_026202.4) A6X929 CCD50_MOUSE ENSMUST00000100026.1 ENSMUST00000100026.2 ENSMUST00000100026.3 ENSMUST00000100026.4 ENSMUST00000100026.5 ENSMUST00000100026.6 ENSMUST00000100026.7 ENSMUST00000100026.8 ENSMUST00000100026.9 NM_026202 Q3TRW1 Q810U5 Q8BP82 Q9CZT1 Q9D436 uc007yvo.1 uc007yvo.2 uc007yvo.3 uc007yvo.4 uc007yvo.5 Involved in EGFR signaling. Interacts with RNF126. Cytoplasm Note=Associated with microtubules of the cytoskeleton and mitotic apparatus. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q810U5-1; Sequence=Displayed; Name=2; IsoId=Q810U5-2; Sequence=VSP_014986; Name=3; IsoId=Q810U5-3; Sequence=VSP_014987; Widely expressed. At 14.5 dpc, strong punctate expression in the otic mesenchyme. Detected in the cells lining the lumen of the primitive cochlear duct and in the nerve fibers of the spiral ganglion, as well as in the nerve fibers invading the cochlear epithelium. At 17.5 dpc, detected only in the mesenchyme around the cochlear duct. 2 days after birth (P2), the mesenchymal expression becomes weaker, except in the region of the spiral limbus, while expression is observed for the first time in the apical region of the developing pillar cells (PCs). Also observed in the cytoplasm of outer hair cells, in their innervating nerve fibers and in the marginal cells of stria vascularis. At P9 and P12, detected in the stria vascularis and strongly through the entire length of the inner and outer PCs. At these stages, in tissues of mesenchymal origin, restricted to the spiral limbus and the spiral ligament. At P14 and P16, strong expression is maintained in the PCs and in the marginal cells of the stria vascularis, weak expression in the spiral limbus and ligament. Also detected in Deiter's cells. At P19 and P22, intense expression in the PCs and stria vascularis, as well as in the cell bodies and processes of Deiter's cells. Weak expression in the spiral limbus and ligament. At P31, when the inner ear is functionally mature, expressed only in the PCs and stria vascularis. At P69, strong expression in the PCs and less intense in stria vascularis. In the vestibular maculae and the cristae ampullaris, expression similar to that observed in the cochlea: strong signal in the mesenchyme at the initial embryonic stages that progressively becomes weaker and is less prominent in the adult (P33). At 17.5 dpc and P2, observed in nerve fibers innervating the sensory epithelia. Expression in the vestibular epithelium starts at 17.5 dpc and is readily detected at P2. Later expression increases and persists in adult stages in which it is restricted to the apical cytoplasm of the epithelial cells (at protein level). Phosphorylated on tyrosine residues. Sequence=BAB28089.1; Type=Frameshift; Evidence=; cytoplasm cytosol sensory perception of sound ubiquitin protein ligase binding microtubule uc007yvo.1 uc007yvo.2 uc007yvo.3 uc007yvo.4 uc007yvo.5 
ENSMUST00000100041.9 Erich2 ENSMUST00000100041.9 glutamate rich 2 (from RefSeq NM_025744.2) 4933404M02Rik E9Q1A6 E9Q1A6_MOUSE ENSMUST00000100041.1 ENSMUST00000100041.2 ENSMUST00000100041.3 ENSMUST00000100041.4 ENSMUST00000100041.5 ENSMUST00000100041.6 ENSMUST00000100041.7 ENSMUST00000100041.8 Erich2 NM_025744 uc008jzh.1 uc008jzh.2 molecular_function cellular_component biological_process uc008jzh.1 uc008jzh.2 
ENSMUST00000100043.3 Sp5 ENSMUST00000100043.3 trans-acting transcription factor 5 (from RefSeq NM_022435.2) ENSMUST00000100043.1 ENSMUST00000100043.2 NM_022435 Q149T2 Q9JHX2 SP5_MOUSE uc008jzg.1 uc008jzg.2 uc008jzg.3 Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo. Nucleus. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Belongs to the Sp1 C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus regulation of transcription from RNA polymerase II promoter post-anal tail morphogenesis sequence-specific DNA binding metal ion binding bone morphogenesis cellular response to organic cyclic compound uc008jzg.1 uc008jzg.2 uc008jzg.3 
ENSMUST00000100050.4 Klhl41 ENSMUST00000100050.4 kelch-like 41 (from RefSeq NM_001081087.1) A2AUC9 B2RWT7 ENSMUST00000100050.1 ENSMUST00000100050.2 ENSMUST00000100050.3 KLH41_MOUSE Kbtbd10 NM_001081087 uc008jyg.1 uc008jyg.2 uc008jyg.3 Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. Interacts with NRAP. Part of a complex that contains CUL3, RBX1 and KLHL41. Interacts with LASP1. Cytoplasm toplasm, cytoskeleton Cell projection, pseudopodium Cell projection, ruffle Cytoplasm, myofibril, sarcomere, M line Sarcoplasmic reticulum membrane Endoplasmic reticulum membrane Note=Predominantly cytoplasmic but can colocalize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia. Skeletal muscle. Localized between laterally fusing myofibrils in skeletal muscle (at protein level). Expressed at a lower level in the heart compared to skeletal muscle. Expressed in the myotome part of the mature somites in embryos from embryonic day 9.5 onwards. It is not expressed in the developing heart at these embryonic stages. Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination. ruffle nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol cytoskeleton plasma membrane membrane sarcoplasmic reticulum protein ubiquitination myofibril assembly pseudopodium regulation of lateral pseudopodium assembly M band Cul3-RING ubiquitin ligase complex sarcoplasmic reticulum membrane skeletal muscle cell differentiation cell projection sarcomere organization regulation of myoblast differentiation skeletal muscle fiber development regulation of myoblast proliferation regulation of skeletal muscle cell differentiation uc008jyg.1 uc008jyg.2 uc008jyg.3 
ENSMUST00000100052.11 Igf2bp2 ENSMUST00000100052.11 insulin-like growth factor 2 mRNA binding protein 2 (from RefSeq NM_183029.2) A6X8Z4 ENSMUST00000100052.1 ENSMUST00000100052.10 ENSMUST00000100052.2 ENSMUST00000100052.3 ENSMUST00000100052.4 ENSMUST00000100052.5 ENSMUST00000100052.6 ENSMUST00000100052.7 ENSMUST00000100052.8 ENSMUST00000100052.9 IF2B2_MOUSE Imp2 NM_183029 Q3TCU4 Q5SF07 Q7TQF9 Vickz2 uc007ysb.1 uc007ysb.2 RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts (By similarity). Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (By similarity). Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Interacts with HNRPD. Interacts with IGF2BP1. Interacts with ELAVL1, DHX9, HNRNPU, MATR3 and PABPC1. Nucleus Cytoplasm Cytoplasm, P-body Cytoplasm, Stress granule Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SF07-1; Sequence=Displayed; Name=2; IsoId=Q5SF07-2; Sequence=VSP_019576; Expressed in oocytes, granulosa cells of small and growing follicles and Leydig cells of the testis (at protein level). Expressed in testis and ovary. Expressed in zygotes and blastocysts (at protein level). Expressed in gonads at 12.5, 14.5 and 16.5 dpc (at protein level). Expressed during fetal development at 12.5, 14.5 and 17.5 dpc and declining towards birth. Domains KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules. Belongs to the RRM IMP/VICKZ family. nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding nucleus cytoplasm cytosol cytoskeleton regulation of translation mRNA 5'-UTR binding mRNA transport uc007ysb.1 uc007ysb.2 
ENSMUST00000100064.9 Scn9a ENSMUST00000100064.9 sodium channel, voltage-gated, type IX, alpha, transcript variant 1 (from RefSeq NM_001290674.1) A2ASI7 ENSMUST00000100064.1 ENSMUST00000100064.2 ENSMUST00000100064.3 ENSMUST00000100064.4 ENSMUST00000100064.5 ENSMUST00000100064.6 ENSMUST00000100064.7 ENSMUST00000100064.8 Kiaa4197 NM_001290674 Q5DTI0 Q62205 SCN9A_MOUSE Scn9a uc008jxe.1 uc008jxe.2 uc008jxe.3 uc008jxe.4 uc008jxe.5 uc008jxe.6 uc008jxe.7 Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:15123669). It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:15314237). The sodium channel complex consists of a large, channel- forming alpha subunit (SCN9A) regulated by one or more beta subunits (SCN1B, SCN2B, SCN3B and SCN4B) (By similarity). SCN1B and SCN3B are non-covalently associated with SCN2A. SCN2B and SCN4B are disulfide- linked to SCN2A (By similarity). Interacts with NEDD4 and NEDD4L (PubMed:15123669). Interacts with TMEM233 (PubMed:37117223). Interacts with the conotoxin GVIIJ (By similarity). Cell membrane ; Multi-pass membrane protein Cell projection, neuron projection Note=In neurite terminals. Expressed strongly in sciatic nerves, with moderate levels in kidney (PubMed:31647222). Not detected in liver, brain and muscle (PubMed:31647222). The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4. Phosphorylation at Ser-1488 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily. voltage-gated sodium channel complex ion channel activity voltage-gated ion channel activity voltage-gated sodium channel activity sodium channel activity plasma membrane integral component of plasma membrane ion transport sodium ion transport inflammatory response response to toxic substance post-embryonic development membrane integral component of membrane neuronal action potential sensory perception of pain axon sodium ion binding regulation of ion transmembrane transport sodium ion transmembrane transport cell projection behavioral response to pain transmembrane transport membrane depolarization during action potential uc008jxe.1 uc008jxe.2 uc008jxe.3 uc008jxe.4 uc008jxe.5 uc008jxe.6 uc008jxe.7 
ENSMUST00000100069.9 Scn3a ENSMUST00000100069.9 sodium channel, voltage-gated, type III, alpha, transcript variant 5 (from RefSeq NM_018732.3) A0A0R5RP23 A0A0R5RP41 A2ASI5 ENSMUST00000100069.1 ENSMUST00000100069.2 ENSMUST00000100069.3 ENSMUST00000100069.4 ENSMUST00000100069.5 ENSMUST00000100069.6 ENSMUST00000100069.7 ENSMUST00000100069.8 NM_018732 SCN3A_MOUSE uc012bwa.1 uc012bwa.2 uc012bwa.3 Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium- selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:29142310). May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells (PubMed:29142310). In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion (PubMed:25172946). Heterooligomer of a large alpha subunit and 2-3 smaller beta subunits. Heterooligomer with SCN2B or SCN4B; disulfide-linked. Interacts with NEDD4L. Interacts with TMEM233 (By similarity). Cell membrane ; Multi-pass membrane protein Basal cell membrane Note=In enterochromaffin cells, localized highly asymmetrically, almost exclusively at the basal side. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2ASI5-1; Sequence=Displayed; Name=2; Synonyms=CbmNav1.3a; IsoId=A2ASI5-2; Sequence=VSP_059663; Name=3; Synonyms=CbmNav1.3b; IsoId=A2ASI5-3; Sequence=VSP_059662, VSP_059663; Expressed in enterochromaffin cells in both colon and small bowel (at protein level) (PubMed:29142310). Expressed in pancreatic alpha and beta cells (PubMed:25172946). Expressed in the hippocampus at late embryonic stages and during the first week after birth. Down-regulated after postnatal day 7. The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. May be ubiquitinated by NEDD4L; which would promote its endocytosis. Phosphorylation at Ser-1453 in a highly conserved cytoplasmic loop slows inactivation of the channel and reduces peak sodium currents. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily. voltage-gated sodium channel complex ion channel activity voltage-gated ion channel activity voltage-gated sodium channel activity sodium channel activity calmodulin binding cytoplasm plasma membrane ion transport sodium ion transport basal plasma membrane membrane integral component of membrane neuronal action potential sensory perception of pain axon sodium ion binding regulation of ion transmembrane transport sodium ion transmembrane transport neuronal cell body response to pyrethroid transmembrane transport cellular response to antibiotic membrane depolarization during action potential uc012bwa.1 uc012bwa.2 uc012bwa.3 
ENSMUST00000100070.5 Samd5 ENSMUST00000100070.5 sterile alpha motif domain containing 5 (from RefSeq NM_177271.3) A0A0R4J186 A0A0R4J186_MOUSE ENSMUST00000100070.1 ENSMUST00000100070.2 ENSMUST00000100070.3 ENSMUST00000100070.4 NM_177271 Samd5 uc007eiw.1 uc007eiw.2 uc007eiw.3 cytoplasm uc007eiw.1 uc007eiw.2 uc007eiw.3 
ENSMUST00000100078.10 Zbtb2 ENSMUST00000100078.10 zinc finger and BTB domain containing 2, transcript variant 1 (from RefSeq NM_001033466.3) ENSMUST00000100078.1 ENSMUST00000100078.2 ENSMUST00000100078.3 ENSMUST00000100078.4 ENSMUST00000100078.5 ENSMUST00000100078.6 ENSMUST00000100078.7 ENSMUST00000100078.8 ENSMUST00000100078.9 Gm1103 NM_001033466 Q3V3W4 Q3V3W4_MOUSE Zbtb2 uc007ehf.1 uc007ehf.2 uc007ehf.3 uc007ehf.4 negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleic acid binding cellular_component uc007ehf.1 uc007ehf.2 uc007ehf.3 uc007ehf.4 
ENSMUST00000100083.5 A930003A15Rik ENSMUST00000100083.5 RIKEN cDNA A930003A15 gene, transcript variant 1 (from RefSeq NR_015488.1) A930003A15Rik ENSMUST00000100083.1 ENSMUST00000100083.2 ENSMUST00000100083.3 ENSMUST00000100083.4 NR_015488 Q3U552 Q3U552_MOUSE uc007ype.1 uc007ype.2 uc007ype.3 uc007ype.4 uc007ype.5 molecular_function cellular_component biological_process uc007ype.1 uc007ype.2 uc007ype.3 uc007ype.4 uc007ype.5 
ENSMUST00000100089.3 Rprm ENSMUST00000100089.3 reprimo, TP53 dependent G2 arrest mediator candidate (from RefSeq NM_023396.5) ENSMUST00000100089.1 ENSMUST00000100089.2 NM_023396 Q8K1G8 Q9JJ72 RPRM_MOUSE uc008jrp.1 uc008jrp.2 May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex. Cytoplasm Membrane ; Single-pass membrane protein By p53/TP53, following X-ray irradiation. 'Reprimo' signifies stop/repress. Belongs to the reprimo family. molecular_function cytoplasm cell cycle arrest regulation of mitotic cell cycle membrane integral component of membrane uc008jrp.1 uc008jrp.2 
ENSMUST00000100099.10 Trmt2a ENSMUST00000100099.10 TRM2 tRNA methyltransferase 2A, transcript variant 6 (from RefSeq NM_001425102.1) E9PUQ7 E9PUQ7_MOUSE ENSMUST00000100099.1 ENSMUST00000100099.2 ENSMUST00000100099.3 ENSMUST00000100099.4 ENSMUST00000100099.5 ENSMUST00000100099.6 ENSMUST00000100099.7 ENSMUST00000100099.8 ENSMUST00000100099.9 NM_001425102 Trmt2a uc007yna.1 uc007yna.2 uc007yna.3 uc007yna.4 Reaction=S-adenosyl-L-methionine + uridine(54) in tRNA = 5- methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42712, Rhea:RHEA-COMP:10167, Rhea:RHEA-COMP:10193, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65315, ChEBI:CHEBI:74447; EC=2.1.1.35; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42713; Evidence=; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. Lacks conserved residue(s) required for the propagation of feature annotation. RNA methylation nucleic acid binding RNA processing methyltransferase activity RNA methyltransferase activity transferase activity methylation uc007yna.1 uc007yna.2 uc007yna.3 uc007yna.4 
ENSMUST00000100123.10 Lrrc74b ENSMUST00000100123.10 leucine rich repeat containing 74B, transcript variant 1 (from RefSeq NM_029053.3) ENSMUST00000100123.1 ENSMUST00000100123.2 ENSMUST00000100123.3 ENSMUST00000100123.4 ENSMUST00000100123.5 ENSMUST00000100123.6 ENSMUST00000100123.7 ENSMUST00000100123.8 ENSMUST00000100123.9 LR74B_MOUSE Lrrc74b NM_029053 Q14BP6 Q3UPS2 Q8BYL7 uc007yle.1 uc007yle.2 uc007yle.3 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14BP6-1; Sequence=Displayed; Name=2; IsoId=Q14BP6-2; Sequence=VSP_028428; Name=3; IsoId=Q14BP6-3; Sequence=VSP_028429, VSP_028430; molecular_function cellular_component biological_process uc007yle.1 uc007yle.2 uc007yle.3 
ENSMUST00000100125.12 Thap7 ENSMUST00000100125.12 THAP domain containing 7 (from RefSeq NM_026909.2) ENSMUST00000100125.1 ENSMUST00000100125.10 ENSMUST00000100125.11 ENSMUST00000100125.2 ENSMUST00000100125.3 ENSMUST00000100125.4 ENSMUST00000100125.5 ENSMUST00000100125.6 ENSMUST00000100125.7 ENSMUST00000100125.8 ENSMUST00000100125.9 NM_026909 Q8VCZ3 THAP7_MOUSE uc007yld.1 uc007yld.2 uc007yld.3 Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors. Interacts with HDAC3 and nuclear hormone receptor corepressors. Nucleus Chromosome nucleic acid binding DNA binding nucleus chromosome nuclear speck nuclear membrane identical protein binding intracellular membrane-bounded organelle negative regulation of transcription, DNA-templated metal ion binding protein N-terminus binding C2H2 zinc finger domain binding uc007yld.1 uc007yld.2 uc007yld.3 
ENSMUST00000100136.4 Igll1 ENSMUST00000100136.4 immunoglobulin lambda-like polypeptide 1 (from RefSeq NM_001190325.1) E9QMX0 ENSMUST00000100136.1 ENSMUST00000100136.2 ENSMUST00000100136.3 IGLL1_MOUSE Igl-5 NM_001190325 P20764 Q5W1K3 uc007yje.1 uc007yje.2 Critical for B-cell development. Interacts with VPREB1 (By similarity). Interacts with SYNV1/HRD1 (via N-terminus); this interaction leads to increased IGLL1 ubiquitination and degradation in pre-B cells, possibly through a lysosomal, not proteasomal, pathway (PubMed:29907570). Endoplasmic reticulum Secreted Note=In pre-B cells, localizes predominantly to the endoplasmic reticulum. Selectively expressed in pre-B lymphocytes. antigen binding protein binding extracellular region phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc007yje.1 uc007yje.2 
ENSMUST00000100162.5 Copz1 ENSMUST00000100162.5 coatomer protein complex, subunit zeta 1, transcript variant 2 (from RefSeq NM_019817.2) Copz1 ENSMUST00000100162.1 ENSMUST00000100162.2 ENSMUST00000100162.3 ENSMUST00000100162.4 NM_019817 Q542M2 Q542M2_MOUSE uc007xxv.1 uc007xxv.2 uc007xxv.3 uc007xxv.4 The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the adaptor complexes small subunit family. intracellular protein transport retrograde vesicle-mediated transport, Golgi to ER intra-Golgi vesicle-mediated transport membrane vesicle-mediated transport membrane coat COPI vesicle coat uc007xxv.1 uc007xxv.2 uc007xxv.3 uc007xxv.4 
ENSMUST00000100164.5 Hoxc4 ENSMUST00000100164.5 homeobox C4 (from RefSeq NM_013553.2) ENSMUST00000100164.1 ENSMUST00000100164.2 ENSMUST00000100164.3 ENSMUST00000100164.4 HXC4_MOUSE Hox-3.5 Hoxc-4 NM_013553 Q08624 uc007xxg.1 uc007xxg.2 uc007xxg.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus. Belongs to the Antp homeobox family. Deformed subfamily. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification activating transcription factor binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter embryonic organ morphogenesis embryonic skeletal system morphogenesis cartilage development HMG box domain binding positive regulation of male germ-line stem cell asymmetric division uc007xxg.1 uc007xxg.2 uc007xxg.3 
ENSMUST00000100167.10 Abcc1 ENSMUST00000100167.10 ATP-binding cassette, sub-family C member 1, transcript variant 3 (from RefSeq NR_189144.1) Abcc1 Abcc1a Abcc1b ENSMUST00000100167.1 ENSMUST00000100167.2 ENSMUST00000100167.3 ENSMUST00000100167.4 ENSMUST00000100167.5 ENSMUST00000100167.6 ENSMUST00000100167.7 ENSMUST00000100167.8 ENSMUST00000100167.9 MRP1_MOUSE Mdrap Mrp NR_189144 O35379 uc007yhj.1 uc007yhj.2 uc007yhj.3 uc007yhj.4 Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595, PubMed:9359705). Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (PubMed:9359705). Mediates ATP- dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.; EC=7.6.2.2; Evidence=; Reaction=an S-substituted glutathione(in) + ATP + H2O = ADP + an S- substituted glutathione(out) + H(+) + phosphate; Xref=Rhea:RHEA:19121, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:90779, ChEBI:CHEBI:456216; EC=7.6.2.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19122; Evidence=; Reaction=ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate; Xref=Rhea:RHEA:38963, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57973, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38964; Evidence=; Reaction=ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out); Xref=Rhea:RHEA:38951, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:60119, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38952; Evidence=; Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:82961, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60129; Evidence=; Reaction=ATP + H2O + vincristine(in) = ADP + H(+) + phosphate + vincristine(out); Xref=Rhea:RHEA:60160, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143658, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60161; Evidence=; Reaction=ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate; Xref=Rhea:RHEA:33147, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:64677, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33148; Evidence=; Reaction=2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:74887, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143093, ChEBI:CHEBI:456216; Evidence=; MK 571 inhibits sphingosine 1-phosphate and leukotriene C4 export. Kinetic parameters: KM=60 nM for leukotriene C4 ; KM=3.3 nM for S-(2,4-dinitrophenyl)glutathione ; Vmax=350 pmol/min/mg enzyme for leukotriene C4 transport ; Cell membrane ; Multi-pass membrane protein Homozygous ABCC1 knockout mice are healthy and fertile up to at least 12 months of age. They are hypersensitive to anticancer drugs resulting in an increased loss of body weight and mortality and have a decreased inflammatory response. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. nucleotide binding long-chain fatty acid transporter activity ATP binding cytoplasm plasma membrane integral component of plasma membrane drug transmembrane transport response to oxidative stress xenobiotic-transporting ATPase activity glutathione S-conjugate-exporting ATPase activity efflux transmembrane transporter activity plasma membrane long-chain fatty acid transport membrane integral component of membrane basolateral plasma membrane hydrolase activity ATPase activity transmembrane transporter activity positive regulation of cell migration phospholipid efflux lipid-transporting ATPase activity glutathione transmembrane transporter activity glutathione transmembrane transport response to drug ATPase activity, coupled to transmembrane movement of substances amide transmembrane transporter activity xenobiotic transport xenobiotic transporter activity phospholipid translocation drug export sphingolipid transporter activity positive regulation of inflammatory response transmembrane transport cell chemotaxis negative regulation of cell death leukotriene transport sphingolipid translocation negative regulation of neuron death uc007yhj.1 uc007yhj.2 uc007yhj.3 uc007yhj.4 
ENSMUST00000100179.2 Krt76 ENSMUST00000100179.2 keratin 76 (from RefSeq NM_001033177.2) ENSMUST00000100179.1 K22O_MOUSE Krt76 NM_001033177 Q3UV17 uc007xue.1 uc007xue.2 Probably contributes to terminal cornification. Heterotetramer of two type I and two type II keratins. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. molecular_function intermediate filament epidermis development pigmentation keratin filament sebaceous gland development uc007xue.1 uc007xue.2 
ENSMUST00000100193.8 Septin9 ENSMUST00000100193.8 septin 9, transcript variant 4 (from RefSeq NM_017380.2) A2A6U2 A2A6U4 A2A6U6 ENSMUST00000100193.1 ENSMUST00000100193.2 ENSMUST00000100193.3 ENSMUST00000100193.4 ENSMUST00000100193.5 ENSMUST00000100193.6 ENSMUST00000100193.7 Kiaa0991 NM_017380 Q3URP2 Q80TM7 Q80UG5 Q9QYX9 SEPT9_MOUSE Sept9 Septin9 Sint1 uc007mnf.1 uc007mnf.2 uc007mnf.3 uc007mnf.4 Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments, and microtubules. GTPase activity is required for filament formation. Interacts with SEPTIN2, SEPTIN6, SEPTIN7, SEPTIN11 and SEPTIN14. Interacts with RTKN and ARHGEF18 (By similarity). Cytoplasm, cytoskeleton Note=In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes with actin stress fibers. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80UG5-1; Sequence=Displayed; Name=2; IsoId=Q80UG5-2; Sequence=VSP_012341; Name=3; IsoId=Q80UG5-3; Sequence=VSP_012342; Expressed in all tissues examined except muscle. Isoforms are differentially expressed in testes, kidney, liver, heart, spleen and brain. At 8 dpc mainly expressed in the lateral plate mesoderm and the somites. Beginning at 9 dpc the lateral plate expression is clearly focused in the developing fore- and hindlimb buds. In the cephalic region, expressed in the first and second branchial arch, in the nasal process and around the otic pit. At 9.5 dpc strongest expression is observed in the mesenchyme of the branchial arches, the limbs, and the developing dorsal root ganglia. Weak to intermediate expression is found in the neural epithelium. Expression is seen in the newly formed somites in the tail bud of older embryos. During formation of the digits, expression seems to outline the surviving tissue bordering it towards the apoptotic webbing. Expression is seen in the developing outer ear and in several areas known to be regulated by intensive epithelial mesenchymal interactions, like the viscera follicles and the developing mammary glands. Note=Putative proto-oncogene involved in T-cell lymphomagenesis. May play a role in leukemogenesis. Targeted by proviral insertion in T-cell lymphomas induced by the murine retrovirus SL3-3 MuLV. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. Sequence=BAC65697.2; Type=Erroneous initiation; Evidence=; nucleotide binding stress fiber GTPase activity protein binding GTP binding cytoplasm cytoskeleton microtubule axoneme septin ring cell cycle actin cytoskeleton microtubule cytoskeleton septin complex perinuclear region of cytoplasm protein heterooligomerization cell division cytoskeleton-dependent cytokinesis non-motile cilium positive regulation of non-motile cilium assembly uc007mnf.1 uc007mnf.2 uc007mnf.3 uc007mnf.4 
ENSMUST00000100196.9 Alg1 ENSMUST00000100196.9 ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase (from RefSeq NM_145362.2) ALG1_MOUSE Alg1 ENSMUST00000100196.1 ENSMUST00000100196.2 ENSMUST00000100196.3 ENSMUST00000100196.4 ENSMUST00000100196.5 ENSMUST00000100196.6 ENSMUST00000100196.7 ENSMUST00000100196.8 NM_145362 Q3UKT8 Q921Q3 uc007yby.1 uc007yby.2 uc007yby.3 uc007yby.4 Catalyzes the addition of the first of nine mannose moieties to form a dolichol-lipid linked oligosaccharide intermediate required for proper N-linked glycosylation. Reaction=GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol = beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D- GlcNAc-diphosphodolichol + GDP + H(+); Xref=Rhea:RHEA:13865, Rhea:RHEA-COMP:9520, Rhea:RHEA-COMP:11044, ChEBI:CHEBI:15378, ChEBI:CHEBI:57269, ChEBI:CHEBI:57527, ChEBI:CHEBI:58189, ChEBI:CHEBI:58472; EC=2.4.1.142; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13866; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q921Q3-1; Sequence=Displayed; Name=2; IsoId=Q921Q3-2; Sequence=VSP_032516; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily. Sequence=BC011281; Type=Frameshift; Evidence=; mannosyltransferase activity chitobiosyldiphosphodolichol beta-mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups mannosylation uc007yby.1 uc007yby.2 uc007yby.3 uc007yby.4 
ENSMUST00000100202.10 Rnf157 ENSMUST00000100202.10 ring finger protein 157, transcript variant 1 (from RefSeq NM_027258.2) A2AAN9 A2AAN9_MOUSE ENSMUST00000100202.1 ENSMUST00000100202.2 ENSMUST00000100202.3 ENSMUST00000100202.4 ENSMUST00000100202.5 ENSMUST00000100202.6 ENSMUST00000100202.7 ENSMUST00000100202.8 ENSMUST00000100202.9 NM_027258 Rnf157 uc007mky.1 uc007mky.2 uc007mky.3 uc007mky.4 E3 ubiquitin ligase. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence= Cytoplasm cytoplasm protein ubiquitination negative regulation of apoptotic process cell body protein autoubiquitination ubiquitin protein ligase activity positive regulation of dendrite extension uc007mky.1 uc007mky.2 uc007mky.3 uc007mky.4 
ENSMUST00000100203.10 Dip2b ENSMUST00000100203.10 disco interacting protein 2 homolog B, transcript variant 3 (from RefSeq NM_001402901.1) DIP2B_MOUSE ENSMUST00000100203.1 ENSMUST00000100203.2 ENSMUST00000100203.3 ENSMUST00000100203.4 ENSMUST00000100203.5 ENSMUST00000100203.6 ENSMUST00000100203.7 ENSMUST00000100203.8 ENSMUST00000100203.9 Kiaa1463 NM_001402901 Q3UH60 Q8C1W5 Q8CDG9 Q8CHA2 uc007xqq.1 uc007xqq.2 uc007xqq.3 Negatively regulates axonal outgrowth and is essential for normal synaptic transmission (PubMed:32153366). Not required for regulation of axon polarity (PubMed:32153366). Promotes acetylation of alpha-tubulin (PubMed:32153366). Interacts with alpha-tubulin. Cell projection, dendrite Cell projection, axon Perikaryon Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UH60-1; Sequence=Displayed; Name=2; IsoId=Q3UH60-2; Sequence=VSP_031278, VSP_031279; Highly expressed in brain and spinal cord (at protein level) (PubMed:32153366). In brain, expression is detected in the main olfactory bulb, cortex, lateral ventricle, cornu ammonis 1, cornu ammonis 3, dentate gyrus, striatum, cerebellar cortex and medial habenula (PubMed:32153366). Expressed primarily in neurons including excitatory pyramidal neurons and inhibitory interneurons (PubMed:32153366). In the embryo, expression initiates at 15.5 dpc in both the neocortex and hippocampus. Excessive axonal outgrowth and branching with decreased dendritic outgrowth (PubMed:32153366). Reduced acetylation of alpha-tubulin (PubMed:32153366). Belongs to the DIP2 family. Sequence=BAC41112.1; Type=Erroneous initiation; Evidence=; molecular_function catalytic activity nucleus cytoplasm biological_process uc007xqq.1 uc007xqq.2 uc007xqq.3 
ENSMUST00000100206.4 Larp4 ENSMUST00000100206.4 La ribonucleoprotein 4, transcript variant 5 (from RefSeq NM_001284523.1) ENSMUST00000100206.1 ENSMUST00000100206.2 ENSMUST00000100206.3 G3X9Q6 G3X9Q6_MOUSE Larp4 NM_001284523 uc007xqo.1 uc007xqo.2 nucleic acid binding RNA binding cytosol polysome cytoskeleton organization poly(A) binding cytoplasmic stress granule regulation of cell morphogenesis cytosolic small ribosomal subunit positive regulation of translation uc007xqo.1 uc007xqo.2 
ENSMUST00000100209.6 Fam186a ENSMUST00000100209.6 Fam186a (from geneSymbol) AK133226 ENSMUST00000100209.1 ENSMUST00000100209.2 ENSMUST00000100209.3 ENSMUST00000100209.4 ENSMUST00000100209.5 Fam186a K3W4Q5 K3W4Q5_MOUSE uc007xqk.1 uc007xqk.2 uc007xqk.3 uc007xqk.1 uc007xqk.2 uc007xqk.3 
ENSMUST00000100211.11 4930562C15Rik ENSMUST00000100211.11 RIKEN cDNA 4930562C15 gene (from RefSeq NM_030192.1) CP096_MOUSE E9QMW4 ENSMUST00000100211.1 ENSMUST00000100211.10 ENSMUST00000100211.2 ENSMUST00000100211.3 ENSMUST00000100211.4 ENSMUST00000100211.5 ENSMUST00000100211.6 ENSMUST00000100211.7 ENSMUST00000100211.8 ENSMUST00000100211.9 NM_030192 Q3V087 uc012aav.1 uc012aav.2 uc012aav.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9QMW4-1; Sequence=Displayed; Name=2; IsoId=E9QMW4-2; Sequence=VSP_042127; Sequence=BAE21617.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc012aav.1 uc012aav.2 uc012aav.3 
ENSMUST00000100219.5 Dolk ENSMUST00000100219.5 dolichol kinase (from RefSeq NM_177648.3) DOLK_MOUSE Dolk ENSMUST00000100219.1 ENSMUST00000100219.2 ENSMUST00000100219.3 ENSMUST00000100219.4 NM_177648 Q8R2Y3 Tmem15 uc008jby.1 uc008jby.2 uc008jby.3 Catalyzes CTP-mediated phosphorylation of dolichol, the terminal step in de novo dolichyl monophosphate (Dol-P) biosynthesis. Dol-P is a lipid carrier essential for the synthesis of N-linked and O- linked oligosaccharides and for GPI anchors. Reaction=CTP + di-trans,poly-cis-dolichol = a dolichyl phosphate + CDP + H(+); Xref=Rhea:RHEA:13133, Rhea:RHEA-COMP:9517, Rhea:RHEA- COMP:9521, ChEBI:CHEBI:15378, ChEBI:CHEBI:16091, ChEBI:CHEBI:37563, ChEBI:CHEBI:57683, ChEBI:CHEBI:58069; EC=2.7.1.108; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13134; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the polyprenol kinase family. dolichol kinase activity endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane kinase activity phosphorylation transferase activity integral component of endoplasmic reticulum membrane dolichyl monophosphate biosynthetic process uc008jby.1 uc008jby.2 uc008jby.3 
ENSMUST00000100220.5 Spout1 ENSMUST00000100220.5 SPOUT domain containing methyltransferase 1 (from RefSeq NM_172660.4) CI114_MOUSE D2Wsu81e ENSMUST00000100220.1 ENSMUST00000100220.2 ENSMUST00000100220.3 ENSMUST00000100220.4 NM_172660 Q3UHX9 Q8BQY9 Spout1 uc008jbn.1 uc008jbn.2 uc008jbn.3 uc008jbn.4 Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. Also involved in chromosome alignment. May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis. Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (By similarity). Interacts with INCA1. Cytoplasm, cytoskeleton, spindle Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Associated with the outer kinetochore. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UHX9-1; Sequence=Displayed; Name=2; IsoId=Q3UHX9-2; Sequence=VSP_018611; [Isoform 1]: May be due to intron retention. Belongs to the class IV-like SAM-binding methyltransferase superfamily. chromosome, centromeric region kinetochore condensed chromosome kinetochore chromosome cytoplasm microtubule organizing center spindle cytoskeleton cell cycle methyltransferase activity posttranscriptional regulation of gene expression transferase activity spindle pole centrosome methylation production of miRNAs involved in gene silencing by miRNA miRNA binding cell division maintenance of centrosome location mitotic spindle uc008jbn.1 uc008jbn.2 uc008jbn.3 uc008jbn.4 
ENSMUST00000100225.9 Sptan1 ENSMUST00000100225.9 spectrin alpha, non-erythrocytic 1, transcript variant 2 (from RefSeq NM_001177667.1) A3KGU7 A3KGU7_MOUSE ENSMUST00000100225.1 ENSMUST00000100225.2 ENSMUST00000100225.3 ENSMUST00000100225.4 ENSMUST00000100225.5 ENSMUST00000100225.6 ENSMUST00000100225.7 ENSMUST00000100225.8 NM_001177667 Spna2 Sptan1 uc012btk.1 uc012btk.2 uc012btk.3 uc012btk.4 Cytoplasm, cell cortex Cytoplasm, cytoskeleton Belongs to the spectrin family. calcium ion binding uc012btk.1 uc012btk.2 uc012btk.3 uc012btk.4 
ENSMUST00000100237.4 Ttf1 ENSMUST00000100237.4 transcription termination factor, RNA polymerase I, transcript variant 6 (from RefSeq NR_185263.1) ENSMUST00000100237.1 ENSMUST00000100237.2 ENSMUST00000100237.3 NR_185263 Q62187 Q9JKK5 TTF1_MOUSE uc008izk.1 uc008izk.2 uc008izk.3 Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin (PubMed:7720715, PubMed:9267035, PubMed:15292447, PubMed:9049305). Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription (PubMed:15292447, PubMed:20513429). Interaction with BAZ2A/TIP5 recovers DNA-binding activity (PubMed:15292447). Oligomer. The oligomeric structure enables to interact simultaneously with two separate DNA fragments (PubMed:9092622). Interacts with BAZ2A/TIP5 (PubMed:15292447). Interacts with CAVIN1 (PubMed:9582279, PubMed:27528195). Interacts (via the N-terminal region (NRD) and a C-terminal region) with CDKN2A/ARF; the interaction is direct (PubMed:20513429). Interacts (via C-terminal region) with NPM1/B23 (PubMed:20513429). Q62187; Q9UIF9: BAZ2A; Xeno; NbExp=3; IntAct=EBI-11705418, EBI-934890; Nucleus Nucleus, nucleolus Nucleus, nucleoplasm Note=May be localized to the nucleolus in an NPM1/B23-dependent manner (PubMed:20513429). May be displaced from the nucleolus into the nucleoplasm in an CDKN2A/ARF-dependent manner (PubMed:20513429). May shuttle back and forth from nucleoplasm to nucleolus (PubMed:20513429). The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region. DNA binding chromatin binding protein binding nucleus nucleoplasm nucleolus chromatin remodeling DNA-templated transcription, termination transcription initiation from RNA polymerase I promoter termination of RNA polymerase I transcription negative regulation of DNA replication uc008izk.1 uc008izk.2 uc008izk.3 
ENSMUST00000100239.3 Cd300ld5 ENSMUST00000100239.3 CD300 molecule like family member D5 (from RefSeq NM_001101657.2) A2A7W1 A2A7W1_MOUSE Cd300ld4 Cd300ld5 D3Z6G8 D3Z6G9 ENSMUST00000100239.1 ENSMUST00000100239.2 NM_001101657 uc057kmu.1 uc057kmu.2 uc057kmu.3 molecular_function cellular_component biological_process membrane integral component of membrane uc057kmu.1 uc057kmu.2 uc057kmu.3 
ENSMUST00000100240.3 Cd300ld4 ENSMUST00000100240.3 CD300 molecule like family member D4 (from RefSeq NM_001101656.2) A2A7W1 A2A7W1_MOUSE Cd300ld4 Cd300ld5 D3Z6G8 D3Z6G9 ENSMUST00000100240.1 ENSMUST00000100240.2 NM_001101656 uc007mgg.1 uc007mgg.2 uc007mgg.3 uc007mgg.4 uc007mgg.5 molecular_function cellular_component biological_process membrane integral component of membrane uc007mgg.1 uc007mgg.2 uc007mgg.3 uc007mgg.4 uc007mgg.5 
ENSMUST00000100249.10 Endou ENSMUST00000100249.10 endonuclease, polyU-specific, transcript variant 2 (from RefSeq NM_001168693.1) ENDOU_MOUSE ENSMUST00000100249.1 ENSMUST00000100249.2 ENSMUST00000100249.3 ENSMUST00000100249.4 ENSMUST00000100249.5 ENSMUST00000100249.6 ENSMUST00000100249.7 ENSMUST00000100249.8 ENSMUST00000100249.9 NM_001168693 Pp11r Q01084 Q3V188 uc007xky.1 uc007xky.2 uc007xky.3 uc007xky.4 Endoribonuclease that cleaves single-stranded RNAs at 5' of uridylates and releases a product with a 2',3'-cyclic phosphate at the 3'-end. The UU and GU sites are more efficiently cleaved than CU and AU sites. Reaction=ribonucleotidyl-uridine-RNA = a 3'-end 2',3'-cyclophospho- ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA; Xref=Rhea:RHEA:67792, Rhea:RHEA-COMP:10464, Rhea:RHEA-COMP:17354, Rhea:RHEA-COMP:17356, ChEBI:CHEBI:83064, ChEBI:CHEBI:173117, ChEBI:CHEBI:173224; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67793; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Monomer. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3V188-1; Sequence=Displayed; Name=2; IsoId=Q3V188-2; Sequence=VSP_039224; Specifically expressed in T-cells during apoptosis. Expressed in surface heat stable antigen (HSA)-containing T-cells populations (CD4(-)CD8(-)HSA(+), CD4(+)CD8(-)HSA(+), CD4(-)CD8(+)HSA(+), and CD4(+)CD8(+)HSA(+)) and not in the HSA(-) single positive T-cell populations of the thymus or spleen, suggesting that expression is lost during T-cell maturation and is absent at the most mature stages of T-cell development. Belongs to the ENDOU family. RNA binding nuclease activity endonuclease activity endoribonuclease activity scavenger receptor activity extracellular region cytoplasm proteolysis endocytosis immune response female pregnancy serine-type peptidase activity hydrolase activity polysaccharide binding metal ion binding nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc007xky.1 uc007xky.2 uc007xky.3 uc007xky.4 
ENSMUST00000100287.9 Abca8a ENSMUST00000100287.9 ATP-binding cassette, sub-family A member 8a, transcript variant 1 (from RefSeq NM_153145.5) A2AB96 ABC8A_MOUSE Abca8a ENSMUST00000100287.1 ENSMUST00000100287.2 ENSMUST00000100287.3 ENSMUST00000100287.4 ENSMUST00000100287.5 ENSMUST00000100287.6 ENSMUST00000100287.7 ENSMUST00000100287.8 NM_153145 Q6PAV3 Q8C0A9 Q8K442 Q8R0R4 uc011ygu.1 uc011ygu.2 uc011ygu.3 Mediates cholesterol and taurocholate efflux. Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels. Reaction=ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out); Xref=Rhea:RHEA:50052, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36257, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50053; Evidence=; Reaction=ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate; Xref=Rhea:RHEA:39051, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39052; Evidence=; Cholesterol efflux is increased by extracellularly applied taurocholate. Cell membrane ; Multi-pass membrane protein Basolateral cell membrane Note=Predominantly expressed on the sinusoidal plasma membrane. Expressed in lung, heart, liver, skeletal muscle and testis (PubMed:12532264, PubMed:16445568). Highly expressed in the liver, and is also abundant in heart and skeletal muscle (PubMed:28882873). Highly expressed in heart (PubMed:29300488). Expression is first detected at 17 dpc. Down-regulated by digoxin. Belongs to the ABC transporter superfamily. ABCA family. Sequence=BAC27576.1; Type=Frameshift; Evidence=; nucleotide binding lipid transporter activity ATP binding plasma membrane lipid transport membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances intracellular membrane-bounded organelle transmembrane transport uc011ygu.1 uc011ygu.2 uc011ygu.3 
ENSMUST00000100293.9 Smgc ENSMUST00000100293.9 Secreted (from UniProt Q6JHY2) A7UN65 AK132579 ENSMUST00000100293.1 ENSMUST00000100293.2 ENSMUST00000100293.3 ENSMUST00000100293.4 ENSMUST00000100293.5 ENSMUST00000100293.6 ENSMUST00000100293.7 ENSMUST00000100293.8 Muc19 Q3V1B0 Q58E46 Q6IS33 Q6JHY2 Q7TNU8 Q80ZH6 SMGC_MOUSE uc011zxz.1 uc011zxz.2 uc011zxz.3 Secreted Event=Alternative splicing; Named isoforms=6; Comment=Isoform 1 and isoform 2-6 share the first 17 amino acid residues that correspond to the signal sequence.; Name=2; Synonyms=Smgc; IsoId=Q6JHY2-1; Sequence=Displayed; Name=1; Synonyms=Mucin-19; IsoId=Q6PZE0-1; Sequence=External; Name=3; IsoId=Q6JHY2-2; Sequence=VSP_034526; Name=4; IsoId=Q6JHY2-3; Sequence=VSP_034524; Name=5; Synonyms=t-Smgc; IsoId=Q6JHY2-4; Sequence=VSP_034523; Name=6; IsoId=Q6JHY2-5; Sequence=VSP_034525; Detected in terminal tubule cells of the submandibular gland (at protein level). Expressed in submandibular salivary glands of 3-day-old males but not adults. Expression in adult submandibular glands is restricted to females. Isoform 5 is expressed in both 3-day-old and adult sublingual glands. N-glycosylated. Sequence=AAH55490.1; Type=Erroneous initiation; Evidence=; Name=Mucin database; URL="http://www.medkem.gu.se/mucinbiology/databases/"; molecular_function cellular_component extracellular region biological_process uc011zxz.1 uc011zxz.2 uc011zxz.3 
ENSMUST00000100294.3 Gm10837 ENSMUST00000100294.3 Gm10837 (from geneSymbol) AK139107 ENSMUST00000100294.1 ENSMUST00000100294.2 uc288wpg.1 uc288wpg.2 uc288wpg.1 uc288wpg.2 
ENSMUST00000100301.11 Prkcg ENSMUST00000100301.11 protein kinase C, gamma, transcript variant 4 (from RefSeq NR_184421.1) ENSMUST00000100301.1 ENSMUST00000100301.10 ENSMUST00000100301.2 ENSMUST00000100301.3 ENSMUST00000100301.4 ENSMUST00000100301.5 ENSMUST00000100301.6 ENSMUST00000100301.7 ENSMUST00000100301.8 ENSMUST00000100301.9 NR_184421 Prkcc Prkcg Q3UN66 Q3UN66_MOUSE uc029wcz.1 uc029wcz.2 uc029wcz.3 uc029wcz.4 uc029wcz.5 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence= Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain. ; Cell membrane ; Peripheral membrane protein Cell projection, dendrite Cytoplasm, perinuclear region Membrane ; Peripheral membrane protein Synapse, synaptosome Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-dependent protein kinase C activity protein serine/threonine/tyrosine kinase activity ATP binding cytosol plasma membrane protein phosphorylation learning or memory zinc ion binding kinase activity phosphorylation transferase activity dendrite negative regulation of protein ubiquitination positive regulation of mismatch repair intracellular signal transduction negative regulation of protein catabolic process neuron projection negative regulation of neuron apoptotic process protein autophosphorylation metal ion binding perinuclear region of cytoplasm postsynaptic cytosol response to psychosocial stress uc029wcz.1 uc029wcz.2 uc029wcz.3 uc029wcz.4 uc029wcz.5 
ENSMUST00000100305.8 Helz ENSMUST00000100305.8 May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. (from UniProt Q6DFV5) A1L4L4 A2AAU4 AB093209 ENSMUST00000100305.1 ENSMUST00000100305.2 ENSMUST00000100305.3 ENSMUST00000100305.4 ENSMUST00000100305.5 ENSMUST00000100305.6 ENSMUST00000100305.7 HELZ_MOUSE Kiaa0054 Q6DFV5 Q8BZZ6 Q8CHI3 Q8VDI3 uc007mau.1 uc007mau.2 uc007mau.3 May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. Interacts with POLR2A. Interacts with SMYD3; the interaction may bridge SMYD3 and RNA polymerase II (By similarity). Interacts with SMYD2. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6DFV5-1; Sequence=Displayed; Name=2; IsoId=Q6DFV5-2; Sequence=VSP_035796, VSP_035797; Name=3; IsoId=Q6DFV5-3; Sequence=VSP_035795; [Isoform 2]: May be due to intron retention. Belongs to the DNA2/NAM7 helicase family. Sequence=BAC41393.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding RNA binding helicase activity protein binding ATP binding nucleus cytosol hydrolase activity posttranscriptional gene silencing by RNA P granule metal ion binding uc007mau.1 uc007mau.2 uc007mau.3 
ENSMUST00000100309.3 Alg10b ENSMUST00000100309.3 ALG10 alpha-1,2-glucosyltransferase (from RefSeq NM_001033441.4) AG10B_MOUSE ENSMUST00000100309.1 ENSMUST00000100309.2 NM_001033441 Q3TLS4 Q3UGP8 uc007xhk.1 uc007xhk.2 uc007xhk.3 Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N- linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (By similarity). Has a role in maintenance of cochlear outer hair cell function (PubMed:24303013). Reaction=a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)- alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man- (1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)- alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D- GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D- Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)- alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D- Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc- diphosphodolichol + H(+); Xref=Rhea:RHEA:29543, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9528, Rhea:RHEA-COMP:12633, Rhea:RHEA-COMP:12634, ChEBI:CHEBI:15378, ChEBI:CHEBI:57525, ChEBI:CHEBI:57683, ChEBI:CHEBI:132522, ChEBI:CHEBI:132523; EC=2.4.1.256; Evidence=; Interacts with KCNH1 and KCNH2. Cell membrane ; Multi-pass membrane protein Belongs to the ALG10 glucosyltransferase family. dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity endoplasmic reticulum membrane plasma membrane dolichol-linked oligosaccharide biosynthetic process sensory perception of sound membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups auditory receptor cell development potassium ion transmembrane transport uc007xhk.1 uc007xhk.2 uc007xhk.3 
ENSMUST00000100314.4 Cldn10 ENSMUST00000100314.4 claudin 10, transcript variant b (from RefSeq NM_021386.4) CLD10_MOUSE Cldn10a E9PVC8 E9PWP4 E9QMP1 ENSMUST00000100314.1 ENSMUST00000100314.2 ENSMUST00000100314.3 NM_021386 Q8VC62 Q9CX57 Q9Z0S6 uc007uyx.1 uc007uyx.2 uc007uyx.3 uc007uyx.4 This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight unction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Six alternatively spliced transcript variants have been identified, which encode different isoforms with distinct electric charge of the first extracellular loop and with or without the fourth transmembrane region. These isoforms exhibit distinct localization and function in paracellular anion or cation permeability. [provided by RefSeq, Aug 2010]. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function. Can form homodimers both in trans (interaction between CLDN10 molecules in opposing membranes) and in cis (interaction between CLDN10 molecules within one membrane). Q9Z0S6; Q8N6F1-2: CLDN19; Xeno; NbExp=2; IntAct=EBI-15799971, EBI-12256978; Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum Note=Isoform 1, isoform 2 and isoform 4 localize in the cell membrane and at epithelial tight junctions, whereas isoform 3, isoform 5 and isoform 6 are detected in the endoplasmic reticulum. Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Cldn10b; IsoId=Q9Z0S6-1; Sequence=Displayed; Name=2; Synonyms=Cldn10a; IsoId=Q9Z0S6-2; Sequence=VSP_053551; Name=3; Synonyms=Cldn10a_i2; IsoId=Q9Z0S6-3; Sequence=VSP_053551, VSP_053553; Name=4; Synonyms=Cldn10a_i1; IsoId=Q9Z0S6-4; Sequence=VSP_053552; Name=5; Synonyms=Cldn10a_i3; IsoId=Q9Z0S6-5; Sequence=VSP_053552, VSP_053553; Name=6; Synonyms=Cldn10b_i1; IsoId=Q9Z0S6-6; Sequence=VSP_053553; Strong expression detected in brain cortex and kidney and weak expression in lung and cecum. In kidney, detected in thick ascending limb (TAL) of Henle's loop and proximal convoluted tubule (PCT). Isoform 1 is widely expressed, with highest expression detected in brain cortex, kidney and lung. Isoform 2, isoform 3, isoform 4 and isoform 5 are only detected in kidney and uterus. In kidney, the expression of isoform 1 is highest in medulla, with transcripts being detected in medullary thick ascending limb of Henle's loop (mTAL) and outer and inner medullary collecting ducts, whereas isoform 2 (along with isoform 4) is more highly expressed in cortex, with transcripts being detected in PCT, mTAL and cortical collecting duct. Expressed in the inner ear where it is detected in organ of Corti, marginal cells of stria vascularis, Reissner's membrane and spiral limbus (at protein level) (PubMed:14698084). Expressed in salivary glands and skin (PubMed:28771254). Detected in developing kidney at 14 dpc, with levels increasing towards adulthood. Expressed during tooth development: at 12 dpc, detected in the thickening tooth epithelium, at 13.5 dpc in the lingual basal epithelium of the bud epithelium, at 14.5 dpc in lingual epithelium and between 18 dpc to postnatal day 1 in odontoblasts and stratum intermedium. The fourth transmembrane region (161-181), which is missing in isoform 3, isoform 5 and isoform 6, is necessary for integration into tight junctions. Conditional knockout in the thick ascending limb (TAL) of Henle's loop in kidney leads to hypocalcemia, hypermagnesemia, hyperphosphatemia and nephrocalcinosis. [Isoform 4]: Produced by alternative splicing of isoform 2. [Isoform 5]: Produced by alternative splicing of isoform 3. Belongs to the claudin family. structural molecule activity protein binding cytoplasm endoplasmic reticulum plasma membrane bicellular tight junction ion transport membrane integral component of membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding regulation of ion transport uc007uyx.1 uc007uyx.2 uc007uyx.3 uc007uyx.4 
ENSMUST00000100322.4 Slitrk1 ENSMUST00000100322.4 SLIT and NTRK-like family, member 1 (from RefSeq NM_199065.2) ENSMUST00000100322.1 ENSMUST00000100322.2 ENSMUST00000100322.3 NM_199065 Q810C1 Q9CXL0 SLIK1_MOUSE Sltk1 uc007uyc.1 uc007uyc.2 uc007uyc.3 uc007uyc.4 It is involved in synaptogenesis and promotes excitatory synapse differentiation (By similarity). Enhances neuronal dendrite outgrowth (PubMed:14550773). Can form homodimers; homodimerization requires repeat LRR 2 (By similarity). Interacts with YWHAB, YWHAE, YWHAG, YWHAH, SFN, YWHAQ and YWHAZ (By similarity). Membrane ; Single- pass type I membrane protein Secreted Synapse In the adult, significant expression is detected only in the brain. Broadly expressed in embryonic brain with highest expression in subventricular zone, subplate, cortical plate, pyramidal cell layer of hippocampus, thalamus and hypothalamus where levels are highest in ventromedial hypothalamus and medial part of periaqueductal gray matter. Also expressed in mantle layer of spinal cord and in lateral and medial motor columns. In the embryo, expressed from day 10-12 and continues through later gestational development and into adulthood. Undergoes proteolytic cleavage that results in shedding of the ectodomain and cleavage of the C-terminal cytoplasmic tail. Glycosylated. Phosphorylation at Ser-695 is necessary for proper function in promoting neurite outgrowth. Belongs to the SLITRK family. molecular_function extracellular region nervous system development axonogenesis synapse assembly membrane integral component of membrane cell junction adult behavior multicellular organism growth homeostatic process synapse positive regulation of axonogenesis regulation of synapse organization positive regulation of synapse assembly glutamatergic synapse GABA-ergic synapse integral component of postsynaptic density membrane synaptic membrane adhesion regulation of presynapse assembly uc007uyc.1 uc007uyc.2 uc007uyc.3 uc007uyc.4 
ENSMUST00000100330.10 Tanc2 ENSMUST00000100330.10 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 (from RefSeq NM_181071.3) A2A683 A2A690 ENSMUST00000100330.1 ENSMUST00000100330.2 ENSMUST00000100330.3 ENSMUST00000100330.4 ENSMUST00000100330.5 ENSMUST00000100330.6 ENSMUST00000100330.7 ENSMUST00000100330.8 ENSMUST00000100330.9 Kiaa1148 NM_181071 Q3TRZ3 Q5EBP6 Q69ZQ7 TANC2_MOUSE uc007lxm.1 uc007lxm.2 uc007lxm.3 uc007lxm.4 Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. Interacts with KIF1A; the interaction decreases in presence of calcium. Cell projection, dendritic spine Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2A690-1; Sequence=Displayed; Name=2; IsoId=A2A690-2; Sequence=VSP_033551; Belongs to the TANC family. in utero embryonic development molecular_function cellular_component glutamatergic synapse postsynaptic density, intracellular component uc007lxm.1 uc007lxm.2 uc007lxm.3 uc007lxm.4 
ENSMUST00000100335.10 Mrc2 ENSMUST00000100335.10 mannose receptor, C type 2 (from RefSeq NM_008626.3) A2AAB0 ENSMUST00000100335.1 ENSMUST00000100335.2 ENSMUST00000100335.3 ENSMUST00000100335.4 ENSMUST00000100335.5 ENSMUST00000100335.6 ENSMUST00000100335.7 ENSMUST00000100335.8 ENSMUST00000100335.9 Kiaa0709 MRC2_MOUSE NM_008626 Q64449 Q6ZQ64 Q8C6P0 uc007lxi.1 uc007lxi.2 uc007lxi.3 May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V and with C-terminal region of type I collagen/COL1A1 (By similarity). Membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q64449-1; Sequence=Displayed; Name=2; IsoId=Q64449-2; Sequence=VSP_017223, VSP_017224; Highly expressed in heart, lung and kidney, but little or no expression in brain, thymus or adult liver. Expressed at highly endothelialized sites such as those in choroid plexus and kidney glomerulai as well as in chondrocytes in cartilaginous regions of the embryo. Highly expressed at day 7 of embryonic development and detected throughout the later stages of embryonic development. C-type lectin domains 3 to 8 are not required for calcium- dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner (By similarity). Fibronectin type-II domain mediates collagen-binding. Ricin B-type lectin domain contacts with the second C-type lectin domain. Phosphorylated. Mice show impaired mammary tumor growth. Tumors from mice lacking Mrc2 display an abrogation of cellular collagen uptake, a fibrotic state characterized by the accumulation of both basement membrane and interstitial collagens, and an overall tumor size reduction, despite the collagen accumulation. Fibroblasts from mice lacking Mrc2 display a severe impairment of internalization of collagen IV and V and thus, exhibit a general deficiency in uptake and delivery of collagens to vesicular compartments. Fibroblasts also have diminished initial adhesion to collagen as well as impaired migration on fibrillar collagen. Mice with a targeted deletion of Mrc2 exon 2-6 are phenotypically normal, healthy and fertile. This deletion resulted in expression of a protein that lacks the ricin B-type lectin domain, the fibronectin type-II domain and the first C-type lectin domain. Fibroblasts from these mice display C-type lectin activity, but have a defect in collagen-binding and internalization, and an impaired migratory phenotype. Sequence=AAC52729.1; Type=Frameshift; Evidence=; Sequence=BAC35672.1; Type=Erroneous initiation; Evidence=; Name=Functional Glycomics Gateway - Glycan Binding; Note=Endo180; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_252"; transmembrane signaling receptor activity collagen binding plasma membrane endocytosis cell surface membrane integral component of membrane carbohydrate binding collagen catabolic process uc007lxi.1 uc007lxi.2 uc007lxi.3 
ENSMUST00000100337.10 Lmo7 ENSMUST00000100337.10 LIM domain only 7, transcript variant 1 (from RefSeq NM_201529.3) E9PYF4 E9PYF4_MOUSE ENSMUST00000100337.1 ENSMUST00000100337.2 ENSMUST00000100337.3 ENSMUST00000100337.4 ENSMUST00000100337.5 ENSMUST00000100337.6 ENSMUST00000100337.7 ENSMUST00000100337.8 ENSMUST00000100337.9 Lmo7 NM_201529 uc007uvx.1 uc007uvx.2 uc007uvx.3 uc007uvx.4 nucleus nuclear envelope nucleoplasm cytoplasm plasma membrane cell-cell adherens junction protein C-terminus binding cell surface apical plasma membrane regulation of signaling regulation of cell adhesion actinin binding positive regulation of transcription from RNA polymerase II promoter metal ion binding cell-cell adhesion uc007uvx.1 uc007uvx.2 uc007uvx.3 uc007uvx.4 
ENSMUST00000100339.9 Commd6 ENSMUST00000100339.9 COMM domain containing 6, transcript variant 1 (from RefSeq NM_001033132.3) COMD6_MOUSE ENSMUST00000100339.1 ENSMUST00000100339.2 ENSMUST00000100339.3 ENSMUST00000100339.4 ENSMUST00000100339.5 ENSMUST00000100339.6 ENSMUST00000100339.7 ENSMUST00000100339.8 NM_001033132 Q3V4B5 uc007uvt.1 uc007uvt.2 uc007uvt.3 uc007uvt.4 May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Inhibits TNF-induced NFKB1 activation. Homodimer. Interacts (via COMM domain) with COMMD1 (via COMM domain). Does not interact with NFKBIB. Interacts with RELA, RELB, NFKB1/p105. Does not interact with NFKBIB. Interacts with CCDC22, CCDC93, SCNN1B, CUL4A. Nucleus Cytoplasm cellular_component nucleus cytoplasm negative regulation of NF-kappaB transcription factor activity NF-kappaB binding uc007uvt.1 uc007uvt.2 uc007uvt.3 uc007uvt.4 
ENSMUST00000100347.11 Mapt ENSMUST00000100347.11 microtubule-associated protein tau, transcript variant 22 (from RefSeq NM_001403999.1) A2A5Y9 ENSMUST00000100347.1 ENSMUST00000100347.10 ENSMUST00000100347.2 ENSMUST00000100347.3 ENSMUST00000100347.4 ENSMUST00000100347.5 ENSMUST00000100347.6 ENSMUST00000100347.7 ENSMUST00000100347.8 ENSMUST00000100347.9 Mapt Mtapt NM_001403999 P10637 P10638 Q60684 Q60685 Q60686 Q62286 Q91WK4 TAU_MOUSE Tau uc007lwg.1 uc007lwg.2 uc007lwg.3 uc007lwg.4 uc007lwg.5 Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Interacts with MARK1, MARK2, MARK3 and MARK4 (By similarity). Interacts with SQSTM1 when polyubiquitinated (PubMed:15953362). Interacts with PSMC2 through SQSTM1 (PubMed:15953362). Interacts with FKBP4 (By similarity). Binds to CSNK1D (By similarity). Interacts with SGK1 (By similarity). Interacts with EPM2A; the interaction dephosphorylates MAPT at Ser-369 (By similarity). Interacts with PIN1 (By similarity). Interacts with LRRK2 (By similarity). Interacts with LRP1, leading to endocytosis; this interaction is reduced in the presence of LRPAP1/RAP (By similarity). P10637; O08539: Bin1; NbExp=2; IntAct=EBI-774043, EBI-775152; P10637; Q61644: Pacsin1; NbExp=5; IntAct=EBI-774043, EBI-2255561; P10637; P52479: Usp10; NbExp=3; IntAct=EBI-774043, EBI-8327299; Cytoplasm, cytosol Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Cell projection, axon Cell projection, dendrite Secreted Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. Event=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 14 exons. One of these optional exons contains the additional tau/MAP repeat. Two different C-termini are obtained either by the retention or the splicing of intron 13/14.; Name=PNS-Tau; IsoId=P10637-1; Sequence=Displayed; Name=Tau-A; IsoId=P10637-2; Sequence=VSP_003187, VSP_003188; Name=Tau-B; IsoId=P10637-3; Sequence=VSP_003185, VSP_003187, VSP_003188, VSP_003189, VSP_003190; Name=Tau-C; IsoId=P10637-4; Sequence=VSP_003185, VSP_003187, VSP_003188, VSP_003189; Name=Tau-D; IsoId=P10637-5; Sequence=VSP_003185, VSP_003187, VSP_003188; Name=Tau-E; IsoId=P10637-6; Sequence=VSP_003185, VSP_003186, VSP_003187, VSP_003188; Expressed in neurons and at a lower level in the liver and kidney. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. Shorter forms or low molecular weight tau (lMW- tau) are generally expressed at early development stages and longer forms or high molecular weight tau (hMW-tau) in the adult brain. The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats. Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome (By similarity). Phosphorylation at various serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1, CDK1, CDK5, GSK3, MAPK) (a few sites per protein in interphase, more in mitosis), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity- regulating kinase (MARK1, MARK2, MARK3, MARK4), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylated by PHK. Dephosphorylation at several serine and threonine residues by the serine/threonine phosphatase PPP5C. Phosphorylation at Ser-554 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylation at Ser-188 by SGK1 mediates microtubule depolymerization and neurite formation in hippocampal neurons (By similarity). Note=May be involved in the pathogenesis of cytoplasmic inclusions (as Mallory bodies) in livers of mice chronically intoxicated with Griseofulvin or DDC (3,5-diethoxycarbonyl-2,4- dihydrocollidine), a model for human alcoholic hepatitis. Alteration of Tau (abnormal phosphorylation and cross-linking) could contribute to Mallory bodies formation and disturbance of microtubule function in alcoholic liver disease. microtubule cytoskeleton organization neuron migration DNA binding protein binding nucleus cytoplasm cytosol cytoskeleton microtubule plasma membrane axoneme apoptotic process axonogenesis synapse assembly response to nutrient learning or memory memory adult walking behavior microtubule binding axo-dendritic transport intrinsic apoptotic signaling pathway in response to oxidative stress cytoplasmic side of plasma membrane response to organic substance response to lead ion regulation of autophagy negative regulation of gene expression negative regulation of mitochondrial membrane potential positive regulation of neuron projection development postsynaptic density microtubule cytoskeleton tubulin binding membrane nuclear speck SH3 domain binding enzyme binding protein kinase binding axon dendrite growth cone axolemma heat shock protein binding regulation of microtubule polymerization or depolymerization positive regulation of microtubule polymerization neuron projection development negative regulation of intracellular transport positive regulation of superoxide anion generation negative regulation of kinase activity apolipoprotein binding nuclear periphery cytoplasmic ribonucleoprotein granule somatodendritic compartment identical protein binding protein homodimerization activity cell projection neuron projection neuronal cell body axonal growth cone cell body main axon macromolecular complex binding membrane raft tubulin complex positive regulation of axon extension microtubule polymerization mitochondrion transport along microtubule receptor agonist activity intracellular distribution of mitochondria axon extension synapse organization regulation of calcium-mediated signaling mRNA transport chaperone binding protein polymerization protein homooligomerization protein phosphatase 2A binding Hsp90 protein binding regulation of microtubule-based movement regulation of microtubule cytoskeleton organization lipoprotein particle binding negative regulation of mitochondrial fission glial cell projection neurofibrillary tangle supramolecular fiber organization microtubule lateral binding regulation of cellular response to heat positive regulation of long term synaptic depression positive regulation of neuron death positive regulation of protein localization to synapse negative regulation of establishment of protein localization to mitochondrion positive regulation of cellular protein localization negative regulation of tubulin deacetylation amyloid fibril formation regulation of response to DNA damage stimulus uc007lwg.1 uc007lwg.2 uc007lwg.3 uc007lwg.4 uc007lwg.5 
ENSMUST00000100359.3 Kbtbd6 ENSMUST00000100359.3 Kbtbd6 (from geneSymbol) AK159684 E9PYD7 E9PYD7_MOUSE ENSMUST00000100359.1 ENSMUST00000100359.2 Gm5465 Kbtbd6 Zbtbd6 uc007usz.1 uc007usz.2 uc007usz.3 uc007usz.4 uc007usz.1 uc007usz.2 uc007usz.3 uc007usz.4 
ENSMUST00000100369.4 Fam187a ENSMUST00000100369.4 family with sequence similarity 187, member A (from RefSeq NM_025766.2) ENSMUST00000100369.1 ENSMUST00000100369.2 ENSMUST00000100369.3 F187A_MOUSE NM_025766 Q9D3R5 Q9D3Y8 uc007lsu.1 uc007lsu.2 uc007lsu.3 Membrane ; Single-pass type I membrane protein Belongs to the FAM187 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007lsu.1 uc007lsu.2 uc007lsu.3 
ENSMUST00000100378.4 Meioc ENSMUST00000100378.4 meiosis specific with coiled-coil domain (from RefSeq NM_001127576.2) A2AG06 ENSMUST00000100378.1 ENSMUST00000100378.2 ENSMUST00000100378.3 Gm1564 MEIOC_MOUSE Meioc NM_001127576 Q3V2K8 uc011yfv.1 uc011yfv.2 uc011yfv.3 uc011yfv.4 Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle (PubMed:28380054). Interacts with YTHDC2; binds transcripts that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normally (PubMed:26742488, PubMed:28380054, PubMed:29033321). Interacts with RBM46 (PubMed:36001654). A2AG06; B2RR83: Ythdc2; NbExp=4; IntAct=EBI-11664020, EBI-8572369; A2AG06; Q9H6S0: YTHDC2; Xeno; NbExp=2; IntAct=EBI-11664020, EBI-1057466; Cytoplasm cleus Note=at late pachytene a fraction is nuclear. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AG06-1; Sequence=Displayed; Name=2; IsoId=A2AG06-2; Sequence=VSP_038974; Expressed specifically in fetal ovary and postnatal and adult testes (at protein level) (PubMed:26742488). In adult testis expressed in spermatocytes, beginning in preleptotene and extending through most stages of meiotic prophase I, including leptotene, zygotene, and pachytene (PubMed:28380054). In the ovary appears at 13.5 dpc and disappears shortly after. In postnatal testes, expression increases between 5 and 10 dpp and is maintained through adulthood. In male and female germal cells present from preleptotene to diplotene stages of meiosis prophase I. Normal growth but mice are fully infertile with barely detectable ovaries and testes at adulthood. Complete absence of follicles in the ovaries and spermatozoon in the seminiferous tubules and epidymides. In testis, approximately 60% of the tubules contain spermatocytes arrested early in meiosis prophase I, the rest contains only spermatogonia. Testes completely lack postmeiotic germ cells, and are depleted for meiotic germ cells. In some individuals, germ cells does not progress past preleptotene, while in others, germ cells advanced to the zygotene stage of meiotic prophase (PubMed:28380054). protein binding nucleus cytoplasm double-strand break repair synaptonemal complex assembly male meiosis I female meiosis I spermatogenesis spermatid development mRNA stabilization oocyte development metaphase plate congression meiotic cell cycle germline cell cycle switching, mitotic to meiotic cell cycle chromosome organization involved in meiotic cell cycle uc011yfv.1 uc011yfv.2 uc011yfv.3 uc011yfv.4 
ENSMUST00000100392.5 Hrob ENSMUST00000100392.5 homologous recombination factor with OB-fold (from RefSeq NM_153544.3) A2AWS8 ENSMUST00000100392.1 ENSMUST00000100392.2 ENSMUST00000100392.3 ENSMUST00000100392.4 HROB_MOUSE Hrob NM_153544 Q32P12 Q8CDN3 uc007lqz.1 uc007lqz.2 uc007lqz.3 DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. Interacts with MCM8; this interaction is necessary for MCM8- MCM9 helicase complex recruitment to DNA damage sites (By similarity). Interacts with RPA1; this interaction associates HROB with the RPA complex (PubMed:31467087). Nucleus Chromosome Note=Localized to the sites of DNA damage. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q32P12-1; Sequence=Displayed; Name=2; IsoId=Q32P12-2; Sequence=VSP_025656; Deficient female and male mice exhibit infertility associated with impaired ovarian development and arrested male meiosis. molecular_function cellular_component biological_process uc007lqz.1 uc007lqz.2 uc007lqz.3 
ENSMUST00000100396.4 4930407I10Rik ENSMUST00000100396.4 RIKEN cDNA 4930407I10 gene (from RefSeq NM_001166475.1) 4930407I10Rik D3Z5T8 D3Z5T8_MOUSE ENSMUST00000100396.1 ENSMUST00000100396.2 ENSMUST00000100396.3 NM_001166475 uc007wyb.1 uc007wyb.2 uc007wyb.3 molecular_function cellular_component biological_process uc007wyb.1 uc007wyb.2 uc007wyb.3 
ENSMUST00000100399.11 Xrcc6 ENSMUST00000100399.11 Nucleus (from UniProt A0A0R4J187) A0A0R4J187 A0A0R4J187_MOUSE BC051085 ENSMUST00000100399.1 ENSMUST00000100399.10 ENSMUST00000100399.2 ENSMUST00000100399.3 ENSMUST00000100399.4 ENSMUST00000100399.5 ENSMUST00000100399.6 ENSMUST00000100399.7 ENSMUST00000100399.8 ENSMUST00000100399.9 Xrcc6 uc007wxy.1 uc007wxy.2 uc007wxy.3 Nucleus Belongs to the ku70 family. telomere maintenance activation of innate immune response DNA binding DNA helicase activity damaged DNA binding double-stranded DNA binding double-stranded telomeric DNA binding nucleus nucleoplasm transcription factor complex nucleolus cytoplasm double-strand break repair via nonhomologous end joining brain development protein C-terminus binding cyclin binding DNA duplex unwinding macromolecular complex protein-DNA complex telomeric DNA binding Ku70:Ku80 complex transcription regulatory region DNA binding macromolecular complex binding positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of smooth muscle cell proliferation 5'-deoxyribose-5-phosphate lyase activity nonhomologous end joining complex cellular hyperosmotic salinity response cellular response to gamma radiation cellular response to X-ray double-strand break repair via classical nonhomologous end joining uc007wxy.1 uc007wxy.2 uc007wxy.3 
ENSMUST00000100403.9 Tmem106a ENSMUST00000100403.9 transmembrane protein 106A, transcript variant 2 (from RefSeq NM_001359326.1) ENSMUST00000100403.1 ENSMUST00000100403.2 ENSMUST00000100403.3 ENSMUST00000100403.4 ENSMUST00000100403.5 ENSMUST00000100403.6 ENSMUST00000100403.7 ENSMUST00000100403.8 NM_001359326 Q3U4J0 Q3U9D3 Q3UEA5 Q8CIC3 Q8VC04 T106A_MOUSE uc288ckt.1 uc288ckt.2 Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway (PubMed:26215746). Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (PubMed:26215746). May play a role in inhibition of proliferation and migration (By similarity). Cell membrane ; Single-pass membrane protein Expressed in liver, spleen, lung, kidney, lymph nodes and adipose tissue (at protein level) (PubMed:26215746). Expressed by macrophages (PubMed:26215746). Cell surface expression is increased by Thioglycollate in elicited macrophages. Belongs to the TMEM106 family. Sequence=BAE29006.1; Type=Frameshift; Evidence=; Sequence=BAE30734.1; Type=Frameshift; Evidence=; immune system process molecular_function plasma membrane biological_process membrane integral component of membrane CD80 biosynthetic process CD86 biosynthetic process macrophage activation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade innate immune response positive regulation of MHC class II biosynthetic process interleukin-1 beta secretion interleukin-6 secretion positive regulation of nitric oxide metabolic process tumor necrosis factor secretion uc288ckt.1 uc288ckt.2 
ENSMUST00000100404.6 B3glct ENSMUST00000100404.6 beta-3-glucosyltransferase (from RefSeq NM_001081204.2) B3GLT_MOUSE B3galtl B3glct E9QMK8 ENSMUST00000100404.1 ENSMUST00000100404.2 ENSMUST00000100404.3 ENSMUST00000100404.4 ENSMUST00000100404.5 Gm1057 NM_001081204 Q0PCR7 Q149S5 Q8BHT6 uc009aqc.1 uc009aqc.2 uc009aqc.3 O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan (By similarity). Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BHT6-1; Sequence=Displayed; Name=2; IsoId=Q8BHT6-2; Sequence=VSP_020936; Belongs to the glycosyltransferase 31 family. cellular_component endoplasmic reticulum endoplasmic reticulum membrane carbohydrate metabolic process fucose metabolic process protein glycosylation biological_process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups uc009aqc.1 uc009aqc.2 uc009aqc.3 
ENSMUST00000100426.3 Gm10855 ENSMUST00000100426.3 Gm10855 (from geneSymbol) AK158578 ENSMUST00000100426.1 ENSMUST00000100426.2 uc289svq.1 uc289svq.2 uc289svq.1 uc289svq.2 
ENSMUST00000100433.5 Urad ENSMUST00000100433.5 ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylase (from RefSeq NM_001039678.2) ENSMUST00000100433.1 ENSMUST00000100433.2 ENSMUST00000100433.3 ENSMUST00000100433.4 NM_001039678 Prhoxnb Q283N4 URAD_MOUSE uc009aoa.1 uc009aoa.2 uc009aoa.3 Catalyzes the stereoselective decarboxylation of 2-oxo-4- hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. Reaction=5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5- carboxylate + H(+) = (S)-allantoin + CO2; Xref=Rhea:RHEA:26301, ChEBI:CHEBI:15378, ChEBI:CHEBI:15678, ChEBI:CHEBI:16526, ChEBI:CHEBI:58639; EC=4.1.1.97; Evidence=; Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3. Peroxisome Belongs to the OHCU decarboxylase family. cellular_component peroxisome purine nucleobase metabolic process lyase activity carboxy-lyase activity allantoin biosynthetic process urate catabolic process uc009aoa.1 uc009aoa.2 uc009aoa.3 
ENSMUST00000100439.10 Sun2 ENSMUST00000100439.10 Sad1 and UNC84 domain containing 2, transcript variant 2 (from RefSeq NM_001205346.1) ENSMUST00000100439.1 ENSMUST00000100439.2 ENSMUST00000100439.3 ENSMUST00000100439.4 ENSMUST00000100439.5 ENSMUST00000100439.6 ENSMUST00000100439.7 ENSMUST00000100439.8 ENSMUST00000100439.9 NM_001205346 Q3TBU0 Q3U160 Q6B4H2 Q8BJS4 SUN2_MOUSE Sun2 Unc84b uc007wui.1 uc007wui.2 uc007wui.3 uc007wui.4 uc007wui.5 As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome- nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5. Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain- containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents is giving rise to specific assemblies. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain-containing protein. Interacts with SYNE2; the SUN2:SYNE2/KASH2 LINC complex is a heterohexamer; the homotrimeric cloverleave-like conformation of the SUN domain is a prerequisite for LINC complex formation in which three separate SYNE2/KASH2 peptides bind at the interface of adjacent SUN domains. Component of a probable SUN2:KASH5 LINC complex. Interacts with SYNE1 and SYNE3; probably forming respective LINC complexes. Interacts with A-type lamin. Interaction with lamins B1 and C is hardly detectable. Interacts with EMD. Interacts with RAB5A. Interacts with TMEM43 and TMEM201. Interacts with IRAG2 (PubMed:29878215). Q8BJS4; A2A8U2-3: Tmem201; NbExp=3; IntAct=EBI-646914, EBI-12591474; Q8BJS4-3; Q8BJS4-3: Sun2; NbExp=4; IntAct=EBI-16189250, EBI-16189250; Q8BJS4-3; Q6ZWQ0-1: Syne2; NbExp=2; IntAct=EBI-16189250, EBI-16108623; Nucleus inner membrane ; Single-pass type II membrane protein Nucleus envelope dosome membrane ; Single-pass type II membrane protein Note=Colocalizes with KASH5 at sites of telomere attachment in meiocytes. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BJS4-1; Sequence=Displayed; Name=2; IsoId=Q8BJS4-2; Sequence=VSP_039554; Name=3; IsoId=Q8BJS4-3; Sequence=VSP_039553; Highly expressed in heart, placenta and muscle. The proximal coiled coil domain mediates trimerization required for binding to nesprins. The distal coiled coil domain is proposed to dynamically regulate the oligomeric state by locking the SUN domain in an inactive confirmation (PubMed:26688217). The coiled coil domains are proposed to be involved in load-bearing and force transmission from the cytoskeleton (By similarity). The SUN domain may play a role in nuclear anchoring and/or migration. The disulfide bond with SYNE2 is required for stability of the SUN2:SYNE2/KASH2 LINC complex under tensile forces though not required for the interaction. The disulfide bond is proposed to be conserved in LINC complexes involved in force transmission. nuclear chromosome, telomeric region condensed nuclear chromosome protein binding lamin binding nucleus nuclear envelope nuclear inner membrane integral component of nuclear inner membrane endosome nuclear envelope organization endosome membrane membrane integral component of membrane nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration positive regulation of cell migration nuclear migration along microfilament nuclear membrane LINC complex identical protein binding protein anchor meiotic cell cycle centrosome localization cytoskeletal anchoring at nuclear membrane nuclear matrix anchoring at nuclear membrane uc007wui.1 uc007wui.2 uc007wui.3 uc007wui.4 uc007wui.5 
ENSMUST00000100448.3 Gm6878 ENSMUST00000100448.3 predicted gene 6878 (from RefSeq NR_165040.1) ENSMUST00000100448.1 ENSMUST00000100448.2 NR_165040 uc007uky.1 uc007uky.2 uc007uky.3 uc007uky.1 uc007uky.2 uc007uky.3 
ENSMUST00000100467.10 Trrap ENSMUST00000100467.10 transformation/transcription domain-associated protein (from RefSeq NM_001081362.2) E9QLK7 E9QLK7_MOUSE ENSMUST00000100467.1 ENSMUST00000100467.2 ENSMUST00000100467.3 ENSMUST00000100467.4 ENSMUST00000100467.5 ENSMUST00000100467.6 ENSMUST00000100467.7 ENSMUST00000100467.8 ENSMUST00000100467.9 NM_001081362 Trrap uc009alt.1 uc009alt.2 uc009alt.3 Belongs to the PI3/PI4-kinase family. TRA1 subfamily. histone acetyltransferase complex Swr1 complex transcription cofactor activity nucleus nucleoplasm Golgi apparatus kinase activity phosphorylation histone acetylation histone deubiquitination transferase activity STAGA complex transcription factor TFTC complex NuA4 histone acetyltransferase complex histone H4 acetylation histone H2A acetylation regulation of nucleic acid-templated transcription uc009alt.1 uc009alt.2 uc009alt.3 
ENSMUST00000100476.3 Krtap4-6 ENSMUST00000100476.3 keratin associated protein 4-6 (from RefSeq NM_026834.2) ENSMUST00000100476.1 ENSMUST00000100476.2 Krtap4-6 NM_026834 Q3V4B7 Q3V4B7_MOUSE uc007ljl.1 uc007ljl.2 protein binding cellular_component intermediate filament biological_process keratin filament uc007ljl.1 uc007ljl.2 
ENSMUST00000100479.3 Krtap1-4 ENSMUST00000100479.3 keratin associated protein 1-4 (from RefSeq NM_001039502.2) ENSMUST00000100479.1 ENSMUST00000100479.2 Krtap1-4 NM_001039502 OTTMUSG00000004966 Q3V2D6 Q3V2D6_MOUSE uc007ljd.1 uc007ljd.2 uc007ljd.3 molecular_function cellular_component intermediate filament biological_process keratin filament uc007ljd.1 uc007ljd.2 uc007ljd.3 
ENSMUST00000100482.3 Krt26 ENSMUST00000100482.3 keratin 26 (from RefSeq NM_001033397.5) ENSMUST00000100482.1 ENSMUST00000100482.2 K1C26_MOUSE Krt26 NM_001033397 Q3TRJ4 Q3V1H8 uc007lio.1 uc007lio.2 uc007lio.3 uc007lio.4 Heterotetramer of two type I and two type II keratins. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Belongs to the intermediate filament family. structural molecule activity intermediate filament biological_process uc007lio.1 uc007lio.2 uc007lio.3 uc007lio.4 
ENSMUST00000100484.6 Eif3d ENSMUST00000100484.6 eukaryotic translation initiation factor 3, subunit D, transcript variant 1 (from RefSeq NM_018749.3) EIF3D_MOUSE ENSMUST00000100484.1 ENSMUST00000100484.2 ENSMUST00000100484.3 ENSMUST00000100484.4 ENSMUST00000100484.5 Eif3s7 NM_018749 O70194 Q8BLH0 Q8BWW1 uc007wom.1 uc007wom.2 uc007wom.3 mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Cytoplasm The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex. Belongs to the eIF-3 subunit D family. formation of cytoplasmic translation initiation complex cytoplasmic translational initiation cap-dependent translational initiation RNA binding translation initiation factor activity cytoplasm eukaryotic translation initiation factor 3 complex translation translational initiation eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex positive regulation of translation eukaryotic translation initiation factor 3 complex, eIF3m IRES-dependent viral translational initiation viral translational termination-reinitiation mRNA cap binding positive regulation of mRNA binding uc007wom.1 uc007wom.2 uc007wom.3 
ENSMUST00000100487.6 Eif2ak1 ENSMUST00000100487.6 eukaryotic translation initiation factor 2 alpha kinase 1, transcript variant 1 (from RefSeq NM_013557.3) E2AK1_MOUSE ENSMUST00000100487.1 ENSMUST00000100487.2 ENSMUST00000100487.3 ENSMUST00000100487.4 ENSMUST00000100487.5 Eif2ak1 Hri NM_013557 Q2TA96 Q69ZK8 Q8C024 Q8K123 Q9CTP5 Q9D601 Q9Z2R9 uc057lok.1 uc057lok.2 uc057lok.3 Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:11726526, PubMed:12767237, PubMed:16893190). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:11726526, PubMed:16893190). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:11726526, PubMed:16893190). Acts as a key sensor of heme- deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (PubMed:16893190). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (PubMed:16893190). Thanks to this unique heme- sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (PubMed:16893190). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (PubMed:11726526, PubMed:11050009, PubMed:15931390). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (PubMed:11726526). Iron deficiency also triggers activation by full-length DELE1 (By similarity). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S- DELE1), thereby promoting the ATF4-mediated reprogramming (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; In normal conditions, the protein kinase activity is inhibited; inhibition is relieved by various stress conditions (PubMed:12767237, PubMed:14752110). Inhibited by heme: in presence of heme, forms a disulfide-linked inactive homodimer (By similarity). Heme depletion relieves inhibition and stimulates kinase activity by autophosphorylation (PubMed:12767237, PubMed:14752110). Inhibited by the heme metabolites biliverdin and bilirubin (PubMed:16893190). Induced by oxidative stress generated by arsenite treatment (PubMed:12767237). Binding of nitric oxide (NO) to the heme iron in the N-terminal heme-binding domain activates the kinase activity, while binding of carbon monoxide (CO) suppresses kinase activity (PubMed:14752110). Protein kinase activity is also activated upon binding to DELE1 in response to various stress, triggering the integrated stress response (ISR): activated by full-length DELE1 in response to iron deficiency, while it is activated by the processed form of DELE1 (S-DELE1) in response to mitochondrial stress (By similarity). Synthesized in an inactive form that binds to the N-terminal domain of CDC37 (By similarity). Has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosphorylation. The phosphatase PPP5C modulates this activation (By similarity). Homodimer; homodimerizes in presence of heme, forming a disulfide-linked inactive homodimer (By similarity). Interacts with DELE1; binds both to full-length DELE1 and processed form of DELE1 (S-DELE1) in response to stress, leading to activate its protein kinase activity and trigger the integrated stress response (ISR) (By similarity). Q9Z2R9; Q6ZWX6: Eif2s1; NbExp=6; IntAct=EBI-642878, EBI-1202234; Cytoplasm Expressed predominantly in erythroid cells, mature reticulocytes, as well as fetal liver nucleated erythroid cells (PubMed:11689689). At much lower levels, expressed in hepatocytes and bone marrow-derived macrophages (at protein level) (PubMed:17932563). Highly expressed in fetal liver erythroid precursor cells at 14.5 dpc (at protein level). By phenobarbital. Activated by autophosphorylation; phosphorylated predominantly on serine and threonine residues, but also on tyrosine residues (PubMed:9822714, PubMed:11560503). Autophosphorylation at Thr-485 is required for kinase activation (PubMed:12767237). The active autophosphorylated form apparently is largely refractory to cellular heme fluctuations (PubMed:12767237). Mice are viable and fertile without gross morphological abnormalities but display hyperchromic anemia in animals suffering from iron deficiency (PubMed:11726526). Dramatically altered response to diet-induced iron deficiency shifting from an adaptive decrease in red blood cells (RBCs) volume and intracellular hemoglobin content to an increased production of abnormally dense red blood cells (RBCs) with decreasing red cell counts (PubMed:11726526). The decrease in RBC number is the result of increased apoptosis of erythroid precursors (PubMed:11726526). Diminished levels of phosphorylated EIF2S1 in bone marrow-derived macrophages (BMDMs) (PubMed:17932563). Impaired maturation of BMDMs and blunted inflammatory response to LPS with a reduced cytokine production. Impaired phagocytosis of senescent RBCs by macrophages, resulting in a lower phagocytosis index and lower percentage of macrophages with ingested RBC (PubMed:17932563). Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. Was reported, in hepatocytes, to be involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. Was reported that it may also regulate endoplasmic reticulum (ER) stress during acute heme-deficient conditions. However, this paper has been retracted because of improper data manipulation, reuse, and analyses. Sequence=BAD32438.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding acute inflammatory response protein kinase activity protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity protein binding ATP binding cytoplasm regulation of translation protein phosphorylation phagocytosis negative regulation of cell proliferation regulation of translational initiation by eIF2 alpha phosphorylation regulation of eIF2 alpha phosphorylation by heme kinase activity phosphorylation transferase activity negative regulation of translation heme binding macrophage differentiation protein homodimerization activity protoporphyrinogen IX metabolic process protein autophosphorylation regulation of hemoglobin biosynthetic process negative regulation of hemoglobin biosynthetic process iron ion homeostasis response to iron ion starvation uc057lok.1 uc057lok.2 uc057lok.3 
ENSMUST00000100491.2 Defb43 ENSMUST00000100491.2 defensin beta 43 (from RefSeq NM_001039121.1) DFB43_MOUSE ENSMUST00000100491.1 NM_001039121 Q30KM9 uc007uhc.1 uc007uhc.2 Has bactericidal activity. Secreted Belongs to the beta-defensin family. molecular_function extracellular region extracellular space defense response defense response to bacterium innate immune response uc007uhc.1 uc007uhc.2 
ENSMUST00000100492.5 Defb47 ENSMUST00000100492.5 defensin beta 47 (from RefSeq NM_001039125.2) Defb41 Defb47 EG654465 ENSMUST00000100492.1 ENSMUST00000100492.2 ENSMUST00000100492.3 ENSMUST00000100492.4 NM_001039125 Q30KN1 Q30KN1_MOUSE uc007uhb.1 uc007uhb.2 uc007uhb.3 Secreted extracellular space chemotaxis CCR6 chemokine receptor binding chemoattractant activity defense response to bacterium host cell cytosol positive chemotaxis cell chemotaxis uc007uhb.1 uc007uhb.2 uc007uhb.3 
ENSMUST00000100493.3 Defb48 ENSMUST00000100493.3 defensin beta 48 (from RefSeq NM_001037751.4) Defb42 Defb48 EG432867 ENSMUST00000100493.1 ENSMUST00000100493.2 NM_001037751 Q3UW22 Q3UW22_MOUSE uc007uha.1 uc007uha.2 uc007uha.3 Secreted extracellular region extracellular space chemotaxis defense response CCR6 chemokine receptor binding chemoattractant activity defense response to bacterium positive chemotaxis cell chemotaxis uc007uha.1 uc007uha.2 uc007uha.3 
ENSMUST00000100497.11 Actb ENSMUST00000100497.11 actin, beta (from RefSeq NM_007393.5) ACTB_MOUSE ENSMUST00000100497.1 ENSMUST00000100497.10 ENSMUST00000100497.2 ENSMUST00000100497.3 ENSMUST00000100497.4 ENSMUST00000100497.5 ENSMUST00000100497.6 ENSMUST00000100497.7 ENSMUST00000100497.8 ENSMUST00000100497.9 NM_007393 P02570 P60710 P70514 P99021 Q11211 Q3TI89 Q3TVP6 Q64316 Q6ZWM3 uc009ajk.1 uc009ajk.2 uc009ajk.3 This gene encodes a member of the actin family of proteins. Actins are highly conserved proteins that are among the most abundant proteins in eukaryotic cells and are involved in cell motility, structure, and integrity. Localization, stability, and translation of the transcribed mRNA are regulated through the binding of multiple factors to its 3' UTR sequence. Homozygous knockout mice for this gene exhibit embryonic lethality. Numerous pseudogenes of this gene have been identified in the mouse genome. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X03672.1, AK145196.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:23558171, PubMed:25759381). Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra- processive transport along microtubules (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (PubMed:25759381). Each actin can bind to 4 others (By similarity). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, MARCB1/BAF47, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). In muscle cells, the BAF complex also contains DPF3 (By similarity). Found in a complex with XPO6, Ran, ACTB and PFN1 (By similarity). Component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 and VIM (By similarity). Interacts with XPO6 and EMD (By similarity). Interacts with ERBB2 (By similarity). Interacts with GCSAM (By similarity). Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (PubMed:12522145). Interacts with TBC1D21 (PubMed:21128978). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes (By similarity). Interacts with FAM107A (PubMed:21969592). Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The filament contains 8 copies of ACTR1A and 1 ACTB (By similarity). P60710; P97792: Cxadr; NbExp=6; IntAct=EBI-353957, EBI-7429264; P60710; Q923J1: Trpm7; NbExp=2; IntAct=EBI-353957, EBI-8010314; Cytoplasm, cytoskeleton. Nucleus Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the epididymis (at protein level) (PubMed:30659401). Expressed in the kidney (at protein level) (PubMed:31605441). ISGylated. Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization (PubMed:23911929). MICAL1 and MICAL2 produce the (R)- S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (PubMed:23911929). Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. Methylated at His-73 by SETD3 (PubMed:30626964). Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). [Actin, cytoplasmic 1]: N-terminal cleavage of acetylated methionine of immature cytoplasmic actin by ACTMAP. [Actin, cytoplasmic 1, N-terminally processed]: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected. In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Belongs to the actin family. regulation of cyclin-dependent protein serine/threonine kinase activity nucleotide binding stress fiber podosome protein binding ATP binding nucleus cytoplasm cytosol cytoskeleton actin filament plasma membrane focal adhesion axonogenesis postsynaptic density actin cytoskeleton membrane kinesin binding protein kinase binding regulation of transmembrane transporter activity axon cortical cytoskeleton Tat protein binding negative regulation of protein binding macromolecular complex NuA4 histone acetyltransferase complex cytoplasmic ribonucleoprotein granule identical protein binding myelin sheath calyx of Held membrane raft synapse synaptic vesicle endocytosis cell motility nitric-oxide synthase binding regulation of norepinephrine uptake cellular response to electrical stimulus cellular response to cytochalasin B dense body postsynaptic actin cytoskeleton structural constituent of postsynaptic actin cytoskeleton postsynaptic actin cytoskeleton organization glutamatergic synapse regulation of protein localization to plasma membrane negative regulation of cyclin-dependent protein kinase activity ribonucleoprotein complex uc009ajk.1 uc009ajk.2 uc009ajk.3 
ENSMUST00000100507.8 Eif3b ENSMUST00000100507.8 eukaryotic translation initiation factor 3, subunit B (from RefSeq NM_133916.2) EIF3B_MOUSE ENSMUST00000100507.1 ENSMUST00000100507.2 ENSMUST00000100507.3 ENSMUST00000100507.4 ENSMUST00000100507.5 ENSMUST00000100507.6 ENSMUST00000100507.7 Eif3s9 NM_133916 Q8JZQ9 Q922K2 uc009ahr.1 uc009ahr.2 uc009ahr.3 RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2 and HNRPD. Interacts with METTL3. Interacts with DDX3X (By similarity). Q8JZQ9; Q6NZJ6: Eif4g1; NbExp=2; IntAct=EBI-4286513, EBI-8175606; Cytoplasm Cytoplasm, Stress granule Note=Localizes to stress granules following cellular stress. Ubiquitously expressed. The RRM domain mediates interaction with EIF3J. Phosphorylated. Phosphorylation is enhanced upon serum stimulation. Embryonic death. Belongs to the eIF-3 subunit B family. formation of cytoplasmic translation initiation complex cytoplasmic translational initiation nucleic acid binding RNA binding translation initiation factor activity protein binding cytoplasm eukaryotic translation initiation factor 3 complex translation translational initiation regulation of translational initiation eukaryotic 43S preinitiation complex translation initiation factor binding eukaryotic 48S preinitiation complex synapse eukaryotic translation initiation factor 3 complex, eIF3m IRES-dependent viral translational initiation viral translational termination-reinitiation uc009ahr.1 uc009ahr.2 uc009ahr.3 
ENSMUST00000100523.7 Hoxb2 ENSMUST00000100523.7 homeobox B2 (from RefSeq NM_134032.2) A2A739 B9EHW9 ENSMUST00000100523.1 ENSMUST00000100523.2 ENSMUST00000100523.3 ENSMUST00000100523.4 ENSMUST00000100523.5 ENSMUST00000100523.6 HXB2_MOUSE Hox-2.8 NM_134032 P0C1T1 uc007lby.1 uc007lby.2 uc007lby.3 uc007lby.4 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2. Nucleus At 8 dpc, expressed in the developing hindbrain in regions that give rise to rhombomeric segmentations r3, r4 and r5. Belongs to the Antp homeobox family. Proboscipedia subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding morphogenesis of an epithelial sheet DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytosol regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification dorsal/ventral pattern formation nuclear speck rhombomere 3 development rhombomere 4 development facial nerve structural organization sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system morphogenesis skeletal system morphogenesis neural nucleus development uc007lby.1 uc007lby.2 uc007lby.3 uc007lby.4 
ENSMUST00000100526.3 Gm10874 ENSMUST00000100526.3 predicted gene 10874 (from RefSeq NR_157560.1) ENSMUST00000100526.1 ENSMUST00000100526.2 NR_157560 uc291bco.1 uc291bco.2 uc291bco.1 uc291bco.2 
ENSMUST00000100528.5 Ube2z ENSMUST00000100528.5 ubiquitin-conjugating enzyme E2Z (from RefSeq NM_172300.3) A2A6M3 D11Moh35 ENSMUST00000100528.1 ENSMUST00000100528.2 ENSMUST00000100528.3 ENSMUST00000100528.4 NM_172300 Q3TFZ8 Q3U618 Q3UE37 Q7TMY6 Q8BVL2 Q9DAU4 UBE2Z_MOUSE uc007lbd.1 uc007lbd.2 uc007lbd.3 uc007lbd.4 Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence=; Protein modification; protein ubiquitination. Cytoplasm Nucleus Belongs to the ubiquitin-conjugating enzyme family. Sequence=AAH54412.1; Type=Erroneous initiation; Evidence=; Sequence=BAB24097.1; Type=Erroneous initiation; Evidence=; Sequence=BAC37014.1; Type=Frameshift; Evidence=; nucleotide binding cysteine-type endopeptidase inhibitor activity ATP binding nucleus nucleoplasm cytoplasm cytosol ubiquitin-dependent protein catabolic process apoptotic process negative regulation of endopeptidase activity protein ubiquitination transferase activity positive regulation of apoptotic process negative regulation of apoptotic process ubiquitin conjugating enzyme activity uc007lbd.1 uc007lbd.2 uc007lbd.3 uc007lbd.4 
ENSMUST00000100538.4 Zc3h3 ENSMUST00000100538.4 zinc finger CCCH type containing 3, transcript variant 10 (from RefSeq NR_183923.1) ENSMUST00000100538.1 ENSMUST00000100538.2 ENSMUST00000100538.3 Kiaa0150 NR_183923 Q80X78 Q8CHP0 Smicl ZC3H3_MOUSE Zc3hdc3 Zfp623 uc007whf.1 uc007whf.2 uc007whf.3 Required for the export of polyadenylated mRNAs from the nucleus (By similarity). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (PubMed:16115198). Interacts with SMAD1, SMAD3, SMAD4, CPSF2 and CPSF3. Nucleus molecular_function DNA binding nucleus mRNA cleavage and polyadenylation specificity factor complex mRNA 3'-end processing positive regulation of activin receptor signaling pathway SMAD binding metal ion binding mRNA transport R-SMAD binding regulation of mRNA polyadenylation uc007whf.1 uc007whf.2 uc007whf.3 
ENSMUST00000100539.10 Tsc22d4 ENSMUST00000100539.10 Tsc22 domain family, member 4 (from RefSeq NM_023910.7) ENSMUST00000100539.1 ENSMUST00000100539.2 ENSMUST00000100539.3 ENSMUST00000100539.4 ENSMUST00000100539.5 ENSMUST00000100539.6 ENSMUST00000100539.7 ENSMUST00000100539.8 ENSMUST00000100539.9 NM_023910 Q99PD5 Q9D2V9 Q9EQN3 T22D4_MOUSE Thg1-pit Tsc22d4 uc009adu.1 uc009adu.2 uc009adu.3 uc009adu.4 Binds DNA and acts as a transcriptional repressor (PubMed:27827363). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (PubMed:27827363). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low- density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (PubMed:20878296). Forms a homodimer or heterodimer (By similarity). Forms a heterodimer with TSC22D1 isoforms 1 and 2 (By similarity). Interacts with NRBP1 (By similarity). Q9EQN3; Q9Z0X1: Aifm1; NbExp=4; IntAct=EBI-7821198, EBI-773597; Q9EQN3; P62500: Tsc22d1; NbExp=2; IntAct=EBI-7821198, EBI-8296837; Nucleus Cytoplasm Cell projection, dendrite Synapse Note=Localizes away from the nucleus to neurite processes and synaptic termini as cerebellar granular neurons differentiate (PubMed:20878296). Accumulates in the cytoplasm of differentiated Purkinje cells (PubMed:20878296). Localized to both the cytoplasm and nucleus in immature cerebellar granular neurons and atrophic Purkinje cells (PubMed:20878296). Expressed in the liver (at protein level) (PubMed:23307490, PubMed:27827363). Expressed in Purkinje cells and proliferating cerebellar granular neurons (at protein level) (PubMed:20878296). Expressed in the cortex, medulla and papilla of the kidney. Expression starts at 8.5 dpc and undergoes a second peak of activation at 12.5 dpc (PubMed:11707329). At 12.5 dpc, expression encompasses the entire central nervous system, with highest levels in the dorsal root and trigeminal ganglia (PubMed:11707329). Expressed in the granule neurons and Purkinje cells in the external and internal granular layers of the cerebellum from postnatal day 6 (PubMed:20878296). Induced by TGF-beta treatment (PubMed:11707329). Induced by a wasting-associated liver metabolism as a result of a methionine- choline deficient diet or cancer-induced cachectic phenotype (PubMed:23307490). Induced by renal hyperosmotic stress (PubMed:17147695). Involved in the development of hyperglycaemia and insulin resistance in diabetic mouse models (PubMed:27827363). May be involved in altered hepatic lipid handling as part of cancer-induced cachexia (PubMed:23307490). Belongs to the TSC-22/Dip/Bun family. Sequence=AAK02018.1; Type=Frameshift; Evidence=; transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated response to osmotic stress uc009adu.1 uc009adu.2 uc009adu.3 uc009adu.4 
ENSMUST00000100542.10 Ly6c2 ENSMUST00000100542.10 lymphocyte antigen 6 family memberC2, transcript variant 9 (from RefSeq NM_001415998.1) ENSMUST00000100542.1 ENSMUST00000100542.2 ENSMUST00000100542.3 ENSMUST00000100542.4 ENSMUST00000100542.5 ENSMUST00000100542.6 ENSMUST00000100542.7 ENSMUST00000100542.8 ENSMUST00000100542.9 LY6C2_MOUSE Ly6c NM_001415998 P09568 P0CW03 Q58E40 Q8C2D8 uc007wgp.1 uc007wgp.2 uc007wgp.3 Cell membrane ; Lipid-anchor, GPI- anchor plasma membrane cell surface membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway negative regulation of receptor activity uc007wgp.1 uc007wgp.2 uc007wgp.3 
ENSMUST00000100544.11 Agfg2 ENSMUST00000100544.11 ArfGAP with FG repeats 2, transcript variant 4 (from RefSeq NM_001303271.1) Agfg2 ENSMUST00000100544.1 ENSMUST00000100544.10 ENSMUST00000100544.2 ENSMUST00000100544.3 ENSMUST00000100544.4 ENSMUST00000100544.5 ENSMUST00000100544.6 ENSMUST00000100544.7 ENSMUST00000100544.8 ENSMUST00000100544.9 Hrbl NM_001303271 Q3U2K8 Q3U2K8_MOUSE uc009adm.1 uc009adm.2 uc009adm.3 uc009adm.4 uc009adm.5 This gene encodes a paralog of the HIV-1 Rev binding proteins that serve as cellular co-factors for HIV-1 Rev protein in shuttling viral pre-mRNAs from the nucleus to the cytoplasm. The encoded protein contains an ADP-ribosylation factor GTPase activating protein (Arf-GAP) zinc finger domain, several phenylalanine-glycine (FG) motifs and asparagine-proline-phenylalanine (NPF) motifs. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]. GTPase activator activity positive regulation of GTPase activity metal ion binding uc009adm.1 uc009adm.2 uc009adm.3 uc009adm.4 uc009adm.5 
ENSMUST00000100561.10 Cacna1g ENSMUST00000100561.10 calcium channel, voltage-dependent, T type, alpha 1G subunit, transcript variant 1 (from RefSeq NM_009783.3) Cacna1g ENSMUST00000100561.1 ENSMUST00000100561.2 ENSMUST00000100561.3 ENSMUST00000100561.4 ENSMUST00000100561.5 ENSMUST00000100561.6 ENSMUST00000100561.7 ENSMUST00000100561.8 ENSMUST00000100561.9 NM_009783 Q5SUG4 Q5SUG4_MOUSE uc007kys.1 uc007kys.2 uc007kys.3 uc007kys.4 Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Q5SUG4; P51637: Cav3; NbExp=3; IntAct=EBI-6918583, EBI-298576; Membrane ; Multi- pass membrane protein Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. action potential voltage-gated sodium channel complex regulation of heart rate ion channel activity voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated sodium channel activity calcium channel activity protein binding cytoplasm plasma membrane voltage-gated calcium channel complex ion transport calcium ion transport positive regulation of cytosolic calcium ion concentration chemical synaptic transmission low voltage-gated calcium channel activity response to nickel cation artery smooth muscle contraction membrane integral component of membrane neuronal action potential dendrite regulation of ion transmembrane transport sodium ion transmembrane transport regulation of membrane potential neuronal cell body cell body positive regulation of calcium ion-dependent exocytosis perinuclear region of cytoplasm regulation of calcium ion transport transmembrane transport regulation of atrial cardiac muscle cell membrane depolarization calcium ion transport into cytosol calcium ion import calcium ion transmembrane transport cardiac muscle cell action potential involved in contraction membrane depolarization during action potential SA node cell action potential AV node cell action potential SA node cell to atrial cardiac muscle cell signalling AV node cell to bundle of His cell signaling membrane depolarization during AV node cell action potential membrane depolarization during SA node cell action potential voltage-gated calcium channel activity involved in AV node cell action potential voltage-gated calcium channel activity involved SA node cell action potential regulation of heart rate by cardiac conduction scaffold protein binding uc007kys.1 uc007kys.2 uc007kys.3 uc007kys.4 
ENSMUST00000100584.3 Hhla1 ENSMUST00000100584.3 HERV-H LTR-associating 1 (from RefSeq NM_001145096.1) ENSMUST00000100584.1 ENSMUST00000100584.2 HHLA1_MOUSE NM_001145096 Q3TYV2 uc007waa.1 uc007waa.2 Secreted molecular_function cellular_component extracellular region biological_process uc007waa.1 uc007waa.2 
ENSMUST00000100619.11 Gm525 ENSMUST00000100619.11 predicted gene 525 (from RefSeq NM_001033266.2) B2KGT0 CQ067_MOUSE ENSMUST00000100619.1 ENSMUST00000100619.10 ENSMUST00000100619.2 ENSMUST00000100619.3 ENSMUST00000100619.4 ENSMUST00000100619.5 ENSMUST00000100619.6 ENSMUST00000100619.7 ENSMUST00000100619.8 ENSMUST00000100619.9 NM_001033266 Q3V3I5 uc007kwg.1 uc007kwg.2 uc007kwg.3 Secreted molecular_function cellular_component extracellular region biological_process uc007kwg.1 uc007kwg.2 uc007kwg.3 
ENSMUST00000100635.5 Lratd2 ENSMUST00000100635.5 LRAT domain containing 1 (from RefSeq NM_001162926.1) D3YXJ5 D3YXJ5_MOUSE ENSMUST00000100635.1 ENSMUST00000100635.2 ENSMUST00000100635.3 ENSMUST00000100635.4 Fam84b Lratd2 NM_001162926 uc007vya.1 uc007vya.2 uc007vya.3 uc007vya.4 molecular_function cytoplasm plasma membrane biological_process uc007vya.1 uc007vya.2 uc007vya.3 uc007vya.4 
ENSMUST00000100638.4 Tmem253 ENSMUST00000100638.4 transmembrane protein 253 (from RefSeq NM_001033805.3) ENSMUST00000100638.1 ENSMUST00000100638.2 ENSMUST00000100638.3 NM_001033805 Q3UNB8 TM253_MOUSE uc007tnz.1 uc007tnz.2 uc007tnz.3 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007tnz.1 uc007tnz.2 uc007tnz.3 
ENSMUST00000100643.10 Gm6526 ENSMUST00000100643.10 Gm6526 (from geneSymbol) ENSMUST00000100643.1 ENSMUST00000100643.2 ENSMUST00000100643.3 ENSMUST00000100643.4 ENSMUST00000100643.5 ENSMUST00000100643.6 ENSMUST00000100643.7 ENSMUST00000100643.8 ENSMUST00000100643.9 G3X9Q9 G3X9Q9_MOUSE Gm6526 uc288sso.1 uc288sso.2 uc288sso.1 uc288sso.2 
ENSMUST00000100644.10 Tspoap1 ENSMUST00000100644.10 Belongs to the RIMBP family. (from UniProt Q5NCP6) AK051895 Bzrap1 ENSMUST00000100644.1 ENSMUST00000100644.2 ENSMUST00000100644.3 ENSMUST00000100644.4 ENSMUST00000100644.5 ENSMUST00000100644.6 ENSMUST00000100644.7 ENSMUST00000100644.8 ENSMUST00000100644.9 Q5NCP6 Q5NCP6_MOUSE Tspoap1 uc288bfc.1 uc288bfc.2 Belongs to the RIMBP family. uc288bfc.1 uc288bfc.2 
ENSMUST00000100645.5 Eddm3b ENSMUST00000100645.5 epididymal protein 3B (from RefSeq NM_203508.2) ENSMUST00000100645.1 ENSMUST00000100645.2 ENSMUST00000100645.3 ENSMUST00000100645.4 Eddm3b Gm75 NM_203508 Q8K0E4 Q8K0E4_MOUSE uc007tmq.1 uc007tmq.2 uc007tmq.3 uc007tmq.4 molecular_function cellular_component biological_process uc007tmq.1 uc007tmq.2 uc007tmq.3 uc007tmq.4 
ENSMUST00000100647.7 Clip2 ENSMUST00000100647.7 CAP-GLY domain containing linker protein 2, transcript variant 1 (from RefSeq NM_009990.3) CLIP2_MOUSE Cyln2 ENSMUST00000100647.1 ENSMUST00000100647.2 ENSMUST00000100647.3 ENSMUST00000100647.4 ENSMUST00000100647.5 ENSMUST00000100647.6 Kiaa0291 NM_009990 Q7TSI9 Q8CHU1 Q9EP81 Q9Z0H8 uc008zwi.1 uc008zwi.2 uc008zwi.3 uc008zwi.4 Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). Interacts with CLASP1 and CLASP2 (PubMed:11290329). Binds preferentially to tyrosinated microtubules, and only marginally to detyrosinated microtubules (PubMed:16954346). Cytoplasm Cytoplasm, cytoskeleton Note=Localizes preferentially to the ends of tyrosinated microtubules. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z0H8-1; Sequence=Displayed; Name=2; IsoId=Q9Z0H8-2; Sequence=VSP_015683; Expressed in the brain, and very low levels in kidneys. Expressed at 10.5 dpc, expression declines until birth after which it suddenly increases. Expression gradually decreases until postnatal day 10, (the day when DLBs start to occur), then again increases and reaches the levels present in adult brain. protein binding cytoplasm cytoskeleton microtubule cytoplasmic microtubule microtubule binding microtubule plus-end lamellar body microtubule plus-end binding dendritic microtubule uc008zwi.1 uc008zwi.2 uc008zwi.3 uc008zwi.4 
ENSMUST00000100655.5 9130401M01Rik ENSMUST00000100655.5 RIKEN cDNA 9130401M01 gene (from RefSeq NM_029418.4) CH076_MOUSE ENSMUST00000100655.1 ENSMUST00000100655.2 ENSMUST00000100655.3 ENSMUST00000100655.4 NM_029418 Q9D2X8 uc007vta.1 uc007vta.2 uc007vta.3 molecular_function cellular_component biological_process uc007vta.1 uc007vta.2 uc007vta.3 
ENSMUST00000100666.3 Gm7489 ENSMUST00000100666.3 Gm7489 (from geneSymbol) AK139815 ENSMUST00000100666.1 ENSMUST00000100666.2 uc288yat.1 uc288yat.2 uc288yat.1 uc288yat.2 
ENSMUST00000100670.10 Csmd3 ENSMUST00000100670.10 CUB and Sushi multiple domains 3 (from RefSeq NM_001081391.2) CSMD3_MOUSE ENSMUST00000100670.1 ENSMUST00000100670.2 ENSMUST00000100670.3 ENSMUST00000100670.4 ENSMUST00000100670.5 ENSMUST00000100670.6 ENSMUST00000100670.7 ENSMUST00000100670.8 ENSMUST00000100670.9 Kiaa1894 NM_001081391 Q3USM6 Q80T79 Q8BVJ0 Q9D588 uc033gtv.1 uc033gtv.2 Involved in dendrite development. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80T79-3; Sequence=Displayed; Name=2; IsoId=Q80T79-1; Sequence=VSP_027009; Name=3; IsoId=Q80T79-2; Sequence=VSP_009053, VSP_009054, VSP_009055, VSP_009056; Expressed in the apical dendrites of postnatal hippocampal neurons (at protein level). The intracellular region is dispensable for its function. Belongs to the CSMD family. molecular_function plasma membrane membrane integral component of membrane regulation of dendrite development uc033gtv.1 uc033gtv.2 
ENSMUST00000100680.10 Stx2 ENSMUST00000100680.10 syntaxin 2, transcript variant 3 (from RefSeq NM_001286034.1) ENSMUST00000100680.1 ENSMUST00000100680.2 ENSMUST00000100680.3 ENSMUST00000100680.4 ENSMUST00000100680.5 ENSMUST00000100680.6 ENSMUST00000100680.7 ENSMUST00000100680.8 ENSMUST00000100680.9 Epim NM_001286034 Q3TJ55 Q3TJ55_MOUSE Stx2 uc008zsp.1 uc008zsp.2 uc008zsp.3 uc008zsp.4 uc008zsp.5 uc008zsp.6 Belongs to the syntaxin family. SNAP receptor activity cell intracellular protein transport acrosome reaction membrane integral component of membrane vesicle-mediated transport cell differentiation membrane fusion uc008zsp.1 uc008zsp.2 uc008zsp.3 uc008zsp.4 uc008zsp.5 uc008zsp.6 
ENSMUST00000100688.3 4930503E14Rik ENSMUST00000100688.3 RIKEN cDNA 4930503E14 gene (from RefSeq NM_029131.3) 4930503E14Rik ENSMUST00000100688.1 ENSMUST00000100688.2 NM_029131 Q9D583 Q9D583_MOUSE uc007tdj.1 uc007tdj.2 uc007tdj.3 uc007tdj.4 molecular_function cellular_component biological_process uc007tdj.1 uc007tdj.2 uc007tdj.3 uc007tdj.4 
ENSMUST00000100695.4 Gm10377 ENSMUST00000100695.4 predicted gene 10377 (from RefSeq NM_001244671.1) D3YXI8 D3YXI8_MOUSE ENSMUST00000100695.1 ENSMUST00000100695.2 ENSMUST00000100695.3 Gm10376 Gm10377 NM_001244671 uc057krz.1 uc057krz.2 uc057krz.3 molecular_function cellular_component biological_process uc057krz.1 uc057krz.2 uc057krz.3 
ENSMUST00000100713.4 Gm10384 ENSMUST00000100713.4 predicted gene 10384 (from RefSeq NR_175339.1) ENSMUST00000100713.1 ENSMUST00000100713.2 ENSMUST00000100713.3 NR_175339 uc288xqc.1 uc288xqc.2 uc288xqc.3 uc288xqc.1 uc288xqc.2 uc288xqc.3 
ENSMUST00000100719.3 Gm5460 ENSMUST00000100719.3 Gm5460 (from geneSymbol) AK142650 EG432838 ENSMUST00000100719.1 ENSMUST00000100719.2 Gm5460 Q3UQ97 Q3UQ97_MOUSE uc007taf.1 uc007taf.2 transmembrane signaling receptor activity plasma membrane cell surface membrane integral component of membrane toxin transport uc007taf.1 uc007taf.2 
ENSMUST00000100720.2 Gdf2 ENSMUST00000100720.2 growth differentiation factor 2 (from RefSeq NM_019506.4) Bmp9 ENSMUST00000100720.1 GDF2_MOUSE NM_019506 Q3ZAS6 Q9QZE0 Q9WV56 uc007tac.1 uc007tac.2 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Homozygous null mice exhibit malformations of the vasculature and skeleton. [provided by RefSeq, Jul 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF156890.1, AK147029.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Potent circulating inhibitor of angiogenesis (By similarity). Signals through the type I activin receptor ACVRL1 but not other Alks (PubMed:25751889). Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG (PubMed:23300529). Homodimer; disulfide-linked. Detected in extracellular fluid as mature homodimer, and in complex with its propeptide (By similarity). Interacts with ACVRL1, BMPR2 and ACVR2B with high affinity (in vitro) (PubMed:25751889). Identified in a complex with ACVRL1 and ACVR2B (By similarity). Has ten times lower affinity for ACVR2A (in vitro) (PubMed:25751889). Interacts with ENG, forming a heterotetramer with a 2:2 stoichiometry. Can form a heteromeric complex with ENG and ACVRL1 (By similarity). Interacts with type I receptor ACVR1 (By similarity). Secreted A reversible disulfide bond can be formed between the two subunits in the homodimer; this has no effect on GDF2 activity. Belongs to the TGF-beta family. Can promote osteogenic differentiation in vitro (PubMed:25751889). This is probably not physiologically relevant. angiogenesis branching involved in blood vessel morphogenesis vasculogenesis osteoblast differentiation negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation cytokine activity transforming growth factor beta receptor binding protein binding extracellular region extracellular space cell glucose metabolic process cellular iron ion homeostasis growth factor activity negative regulation of endothelial cell migration positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation neuron differentiation negative regulation of cell growth BMP signaling pathway positive regulation of BMP signaling pathway positive regulation of interleukin-8 production activin receptor signaling pathway regulation of apoptotic process regulation of MAPK cascade positive regulation of endothelial cell differentiation positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell development blood vessel morphogenesis pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction positive regulation of cartilage development cellular response to BMP stimulus negative regulation of DNA biosynthetic process regulation of transforming growth factor beta receptor signaling pathway uc007tac.1 uc007tac.2 
ENSMUST00000100723.4 1700024G13Rik ENSMUST00000100723.4 RIKEN cDNA 1700024G13 gene (from RefSeq NM_001034037.1) CJ053_MOUSE ENSMUST00000100723.1 ENSMUST00000100723.2 ENSMUST00000100723.3 NM_001034037 Q3KNL4 uc007syu.1 uc007syu.2 uc007syu.3 Belongs to the UPF0728 family. molecular_function cellular_component biological_process uc007syu.1 uc007syu.2 uc007syu.3 
ENSMUST00000100729.9 Psmd9 ENSMUST00000100729.9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 (from RefSeq NM_026000.2) ENSMUST00000100729.1 ENSMUST00000100729.2 ENSMUST00000100729.3 ENSMUST00000100729.4 ENSMUST00000100729.5 ENSMUST00000100729.6 ENSMUST00000100729.7 ENSMUST00000100729.8 NM_026000 PSMD9_MOUSE Q3TG66 Q9CR00 uc008znk.1 uc008znk.2 uc008znk.3 uc008znk.4 Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process (By similarity). Interacts with PSMC3. Part of a transient complex (modulator) containing PSMD9, PSMC6 and PSMC3 formed during the assembly of the 26S proteasome (By similarity). Belongs to the proteasome subunit p27 family. molecular_function transcription coactivator activity nucleus cytoplasm protein C-terminus binding proteasome regulatory particle, base subcomplex positive regulation of insulin secretion bHLH transcription factor binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion proteasome regulatory particle assembly type B pancreatic cell apoptotic process uc008znk.1 uc008znk.2 uc008znk.3 uc008znk.4 
ENSMUST00000100737.10 P2rx7 ENSMUST00000100737.10 purinergic receptor P2X, ligand-gated ion channel, 7, transcript variant 1 (from RefSeq NM_011027.4) ENSMUST00000100737.1 ENSMUST00000100737.2 ENSMUST00000100737.3 ENSMUST00000100737.4 ENSMUST00000100737.5 ENSMUST00000100737.6 ENSMUST00000100737.7 ENSMUST00000100737.8 ENSMUST00000100737.9 NM_011027 P2RX7_MOUSE P2x7 Q9Z1M0 uc008zlq.1 uc008zlq.2 uc008zlq.3 Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells. Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB (By similarity). Interacts (via C- terminus) with EMP2 (By similarity). Cell membrane ; Multi-pass membrane protein Phosphorylation results in its inactivation. ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel. Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface. Belongs to the P2X receptor family. activation of MAPK activity cell morphogenesis lipopolysaccharide binding purinergic nucleotide receptor activity phagolysosome assembly positive regulation of T cell mediated cytotoxicity positive regulation of protein phosphorylation extracellular ATP-gated cation channel activity ion channel activity protein binding ATP binding integral component of nuclear inner membrane plasma membrane integral component of plasma membrane cell-cell junction protein phosphorylation membrane protein ectodomain proteolysis phospholipid transfer to membrane ion transport cation transport calcium ion transport cell volume homeostasis membrane budding inflammatory response mitochondrion organization plasma membrane organization cell death response to mechanical stimulus response to bacterium external side of plasma membrane response to organic substance response to zinc ion gene expression positive regulation of calcium ion transport into cytosol positive regulation of gene expression programmed cell death positive regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion response to organic cyclic compound channel activity membrane integral component of membrane synaptic vesicle exocytosis protein processing phospholipid scrambling sensory perception of pain protein catabolic process positive regulation of bone mineralization neuromuscular junction cellular response to extracellular stimulus bleb assembly positive regulation of prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production collagen metabolic process response to ATP response to fluid shear stress positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway signaling receptor activity T cell proliferation response to drug identical protein binding neuronal cell body T cell homeostasis positive regulation of apoptotic process positive regulation of catalytic activity NAD transport negative regulation of MAPK cascade positive regulation of MAPK cascade synapse phospholipid translocation positive regulation of ossification negative regulation of bone resorption negative regulation of cell volume positive regulation of glycolytic process ceramide biosynthetic process pore complex assembly skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of protein secretion positive regulation of cytokine secretion positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion defense response to Gram-positive bacterium release of sequestered calcium ion into cytosol response to calcium ion response to electrical stimulus membrane depolarization positive regulation of mitochondrial depolarization excitatory postsynaptic potential positive regulation of lymphocyte apoptotic process cellular response to dsRNA cellular response to organic cyclic compound reactive oxygen species metabolic process extrinsic apoptotic signaling pathway cation transmembrane transport presynapse postsynapse positive regulation of bleb assembly uc008zlq.1 uc008zlq.2 uc008zlq.3 
ENSMUST00000100750.10 Mecp2 ENSMUST00000100750.10 methyl CpG binding protein 2, transcript variant 2 (from RefSeq NM_010788.4) B1AUZ2 B1AUZ3 ENSMUST00000100750.1 ENSMUST00000100750.2 ENSMUST00000100750.3 ENSMUST00000100750.4 ENSMUST00000100750.5 ENSMUST00000100750.6 ENSMUST00000100750.7 ENSMUST00000100750.8 ENSMUST00000100750.9 MECP2_MOUSE NM_010788 Q3TYG1 Q9Z2D6 uc009tnt.1 uc009tnt.2 uc009tnt.3 uc009tnt.4 uc009tnt.5 Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). Interacts with FNBP3 (PubMed:9171351). Interacts with CDKL5 (By similarity). Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells (PubMed:17296936). Interacts with NCOR2 (PubMed:23770565). Interacts with TBL1XR1; bridges interaction between MECP2 and NCOR1 (PubMed:28348241). Interacts with TBL1X; recruits TBL1X to the heterochromatin foci (By similarity). Q9Z2D6; Q61687: Atrx; NbExp=5; IntAct=EBI-1188816, EBI-2657527; Q9Z2D6; Q9Z1T5: Deaf1; NbExp=2; IntAct=EBI-1188816, EBI-2364863; Q9Z2D6; O88895: Hdac3; NbExp=5; IntAct=EBI-1188816, EBI-302263; Q9Z2D6; Q60520: Sin3a; NbExp=5; IntAct=EBI-1188816, EBI-349034; Q9Z2D6; O35846: Smarca2; NbExp=2; IntAct=EBI-1188816, EBI-371564; Q9Z2D6; Q3TKT4: Smarca4; NbExp=2; IntAct=EBI-1188816, EBI-1210244; Q9Z2D6; Q9CU62: Smc1a; NbExp=3; IntAct=EBI-1188816, EBI-2550016; Q9Z2D6; Q9CW03: Smc3; NbExp=3; IntAct=EBI-1188816, EBI-2550068; Q9Z2D6; O70494: Sp3; NbExp=2; IntAct=EBI-1188816, EBI-643514; Q9Z2D6-1; Q60987: Foxg1; NbExp=4; IntAct=EBI-26609102, EBI-11166131; Q9Z2D6-2; Q60987: Foxg1; NbExp=2; IntAct=EBI-26609115, EBI-11166131; Nucleus te=Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. Event=Alternative splicing; Named isoforms=2; Name=A; Synonyms=Beta; IsoId=Q9Z2D6-1; Sequence=Displayed; Name=B; Synonyms=Alpha; IsoId=Q9Z2D6-2; Sequence=VSP_022949; Phosphorylated on Ser-421 by CaMK2 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation. Does not seem to be phosphorylated on Ser-421 in other tissues. [Isoform B]: Ten times higher expression levels than isoform A in brain (at protein level). negative regulation of transcription from RNA polymerase II promoter four-way junction DNA binding chromatin nuclear chromatin heterochromatin transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding behavioral fear response response to hypoxia startle response neurological system process involved in regulation of systemic arterial blood pressure regulation of respiratory gaseous exchange by neurological system process DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding mRNA binding protein binding nucleus nucleoplasm cytoplasm mitochondrion centrosome cytosol inositol metabolic process mitochondrial electron transport, ubiquinol to cytochrome c chromatin silencing regulation of gene expression by genetic imprinting regulation of transcription, DNA-templated glutamine metabolic process cellular biogenic amine metabolic process mitotic spindle organization chemical synaptic transmission synapse assembly brain development respiratory gaseous exchange learning memory long-term memory protein localization transcription factor binding glucocorticoid metabolic process positive regulation of cell proliferation methyl-CpG binding adult locomotory behavior visual learning response to radiation pathogenesis post-embryonic development double-stranded methylated DNA binding regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of G2/M transition of mitotic cell cycle dendrite development negative regulation of angiogenesis histone methylation histone acetylation proprioception sensory perception of pain enzyme binding protein domain specific binding cerebellum development ventricular system development neuron differentiation neuron projection development chromatin DNA binding positive regulation of synaptic plasticity cardiolipin metabolic process negative regulation of protein binding macromolecular complex multicellular organismal response to stress social behavior siRNA binding cellular response to potassium ion regulation of gene expression, epigenetic response to cocaine neuron maturation histone deacetylase binding negative regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration regulation of DNA methylation unmethylated CpG binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated phosphatidylcholine metabolic process protein N-terminus binding regulation of synaptic plasticity negative regulation of astrocyte differentiation catecholamine secretion regulation of synapse organization neuromuscular process controlling posture neuromuscular process negative regulation of smooth muscle cell differentiation excitatory postsynaptic potential long-term synaptic potentiation positive regulation of dendritic spine development negative regulation of dendritic spine development cellular response to isoquinoline alkaloid positive regulation of microtubule nucleation postsynapse glutamatergic synapse positive regulation of histone H3-K9 trimethylation positive regulation of anterograde dense core granule transport positive regulation of retrograde dense core granule transport negative regulation of dendrite extension positive regulation of dendrite extension positive regulation of branching morphogenesis of a nerve positive regulation of DNA methylation promoter-specific chromatin binding negative regulation of primary miRNA processing negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation uc009tnt.1 uc009tnt.2 uc009tnt.3 uc009tnt.4 uc009tnt.5 
ENSMUST00000100757.6 Adam1a ENSMUST00000100757.6 a disintegrin and metallopeptidase domain 1a (from RefSeq NM_172126.2) ADM1A_MOUSE Adam1 ENSMUST00000100757.1 ENSMUST00000100757.2 ENSMUST00000100757.3 ENSMUST00000100757.4 ENSMUST00000100757.5 Ftna NM_172126 Q60617 Q60813 Q80WR7 Q8R533 uc008zjo.1 uc008zjo.2 uc008zjo.3 May be involved in sperm-egg fusion. Heterodimer with ADAM2/fertilin subunit beta. Membrane ; Single-pass type I membrane protein Testis. Expression is low at 20, 22 and 24 days after birth but has increased by day 60. metalloendopeptidase activity protein binding proteolysis binding of sperm to zona pellucida fusion of sperm to egg plasma membrane peptidase activity metallopeptidase activity membrane integral component of membrane hydrolase activity membrane raft metal ion binding uc008zjo.1 uc008zjo.2 uc008zjo.3 
ENSMUST00000100778.5 Gm6288 ENSMUST00000100778.5 Gm6288 (from geneSymbol) AK144804 ENSMUST00000100778.1 ENSMUST00000100778.2 ENSMUST00000100778.3 ENSMUST00000100778.4 uc291kii.1 uc291kii.2 uc291kii.1 uc291kii.2 
ENSMUST00000100780.3 Mansc4 ENSMUST00000100780.3 MANSC domain containing 4 (from RefSeq NM_001034903.3) B2KFS6 ENSMUST00000100780.1 ENSMUST00000100780.2 Gm5887 MANS4_MOUSE NM_001034903 Q3UU94 uc009est.1 uc009est.2 uc009est.3 Membrane ; Single-pass type I membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009est.1 uc009est.2 uc009est.3 
ENSMUST00000100785.7 Oas1e ENSMUST00000100785.7 2'-5' oligoadenylate synthetase 1E, transcript variant 2 (from RefSeq NM_145210.2) ENSMUST00000100785.1 ENSMUST00000100785.2 ENSMUST00000100785.3 ENSMUST00000100785.4 ENSMUST00000100785.5 ENSMUST00000100785.6 NM_145210 Oas1e Q8C2W3 Q8C2W3_MOUSE uc008zib.1 uc008zib.2 uc008zib.3 uc008zib.4 Belongs to the 2-5A synthase family. RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm cytosol immune response transferase activity negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity 2'-5'-oligoadenylate synthetase activity uc008zib.1 uc008zib.2 uc008zib.3 uc008zib.4 
ENSMUST00000100802.11 Nufip2 ENSMUST00000100802.11 nuclear FMR1 interacting protein 2 (from RefSeq NM_001024205.2) ENSMUST00000100802.1 ENSMUST00000100802.10 ENSMUST00000100802.2 ENSMUST00000100802.3 ENSMUST00000100802.4 ENSMUST00000100802.5 ENSMUST00000100802.6 ENSMUST00000100802.7 ENSMUST00000100802.8 ENSMUST00000100802.9 Kiaa1321 NM_001024205 NUFP2_MOUSE Q3TCE2 Q3V195 Q5F2E7 Q80TF1 uc007khd.1 uc007khd.2 uc007khd.3 uc007khd.4 Binds RNA. Interacts with FMR1 (via N-terminus) (PubMed:12837692). Interacts with DDX6 (By similarity). Nucleus Cytoplasm Cytoplasm, Stress granule Note=Localized in both nucleus and cytoplasm in most neurons. In the cortex, distributed in a diffuse way in the nucleus and in the cytoplasm. Localized in the cytoplasm in neurons of the dentate gyrus in the olfactive bulb, in the ependymal epithelium and in the granular layer of the cerebellum. In Purkinje cells, distributed in both cell compartments and in nuclear dots adjacent to the nucleolus (PubMed:12837692). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5F2E7-1; Sequence=Displayed; Name=2; IsoId=Q5F2E7-2; Sequence=VSP_019729; Sequence=BAC65776.1; Type=Erroneous initiation; Evidence=; RNA binding nucleus nucleoplasm cytoplasm cytosol cytoplasmic stress granule nuclear body polysomal ribosome uc007khd.1 uc007khd.2 uc007khd.3 uc007khd.4 
ENSMUST00000100807.3 Gm10392 ENSMUST00000100807.3 predicted gene 10392 (from RefSeq NR_189015.1) ENSMUST00000100807.1 ENSMUST00000100807.2 NR_189015 uc288akc.1 uc288akc.2 uc288akc.1 uc288akc.2 
ENSMUST00000100821.3 Gm7457 ENSMUST00000100821.3 predicted gene 7457 (from RefSeq NR_045707.1) ENSMUST00000100821.1 ENSMUST00000100821.2 NR_045707 uc009epu.1 uc009epu.2 uc009epu.1 uc009epu.2 
ENSMUST00000100837.11 Camk2g ENSMUST00000100837.11 calcium/calmodulin-dependent protein kinase II gamma, transcript variant 19 (from RefSeq NR_188721.1) ENSMUST00000100837.1 ENSMUST00000100837.10 ENSMUST00000100837.2 ENSMUST00000100837.3 ENSMUST00000100837.4 ENSMUST00000100837.5 ENSMUST00000100837.6 ENSMUST00000100837.7 ENSMUST00000100837.8 ENSMUST00000100837.9 KCC2G_MOUSE NR_188721 Q3U3H3 Q8VED3 Q923T9 uc007skv.1 uc007skv.2 uc007skv.3 uc007skv.4 Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (By similarity). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (By similarity). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning (PubMed:30184290). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK- STAT signaling pathway (PubMed:11972023). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17; Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity. CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (By similarity). Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q923T9-1; Sequence=Displayed; Name=2; IsoId=Q923T9-2; Sequence=VSP_004779; Name=3; IsoId=Q923T9-3; Sequence=VSP_004780; The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization. Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. G1/S transition of mitotic cell cycle nucleotide binding response to hypoxia protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity calmodulin binding ATP binding cytoplasm protein phosphorylation calcium ion transport response to oxidative stress multicellular organism development nervous system development postsynaptic density membrane kinase activity phosphorylation sarcoplasmic reticulum transferase activity cell differentiation sarcoplasmic reticulum membrane identical protein binding protein homodimerization activity neuron projection protein autophosphorylation protein oligomerization regulation of relaxation of cardiac muscle regulation of protein localization to plasma membrane uc007skv.1 uc007skv.2 uc007skv.3 uc007skv.4 
ENSMUST00000100844.6 Anxa7 ENSMUST00000100844.6 annexin A7, transcript variant 4 (from RefSeq NM_001422107.1) A0A2C9F2D2 A0A2C9F2D2_MOUSE Anxa7 ENSMUST00000100844.1 ENSMUST00000100844.2 ENSMUST00000100844.3 ENSMUST00000100844.4 ENSMUST00000100844.5 NM_001422107 uc007sjs.1 uc007sjs.2 uc007sjs.3 uc007sjs.4 Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. A pair of annexin repeats may form one binding site for calcium and phospholipid. Belongs to the annexin family. calcium ion binding calcium-dependent phospholipid binding uc007sjs.1 uc007sjs.2 uc007sjs.3 uc007sjs.4 
ENSMUST00000100847.5 Rpl37rt ENSMUST00000100847.5 Rpl37rt (from geneSymbol) ENSMUST00000100847.1 ENSMUST00000100847.2 ENSMUST00000100847.3 ENSMUST00000100847.4 uc290yrx.1 uc290yrx.2 uc290yrx.1 uc290yrx.2 
ENSMUST00000100857.10 Dusp16 ENSMUST00000100857.10 dual specificity phosphatase 16, transcript variant A1 (from RefSeq NM_130447.3) Dusp16 ENSMUST00000100857.1 ENSMUST00000100857.2 ENSMUST00000100857.3 ENSMUST00000100857.4 ENSMUST00000100857.5 ENSMUST00000100857.6 ENSMUST00000100857.7 ENSMUST00000100857.8 ENSMUST00000100857.9 NM_130447 Q6PCP3 Q6PCP3_MOUSE uc009ekp.1 uc009ekp.2 uc009ekp.3 uc009ekp.4 Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. inactivation of MAPK activity protein tyrosine phosphatase activity protein binding nucleus nucleoplasm cytoplasm cytosol protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity peptidyl-tyrosine dephosphorylation negative regulation of MAPK cascade uc009ekp.1 uc009ekp.2 uc009ekp.3 uc009ekp.4 
ENSMUST00000100864.7 Smim10l1 ENSMUST00000100864.7 small integral membrane protein 10 like 1, transcript variant 3 (from RefSeq NM_001163445.2) 2700089E24Rik E9Q3K4 E9Q3K4_MOUSE ENSMUST00000100864.1 ENSMUST00000100864.2 ENSMUST00000100864.3 ENSMUST00000100864.4 ENSMUST00000100864.5 ENSMUST00000100864.6 NM_001163445 Smim10l1 uc009ejz.1 uc009ejz.2 uc009ejz.3 uc009ejz.4 uc009ejz.5 molecular_function cellular_component biological_process uc009ejz.1 uc009ejz.2 uc009ejz.3 uc009ejz.4 uc009ejz.5 
ENSMUST00000100866.3 Ccdc92b ENSMUST00000100866.3 coiled-coil domain containing 92B (from RefSeq NM_001013784.1) Ccdc92b E130309D14Rik ENSMUST00000100866.1 ENSMUST00000100866.2 NM_001013784 Q5SUE3 Q5SUE3_MOUSE uc007kbz.1 uc007kbz.2 molecular_function cellular_component biological_process uc007kbz.1 uc007kbz.2 
ENSMUST00000100874.6 Selplg ENSMUST00000100874.6 selectin, platelet (p-selectin) ligand (from RefSeq NM_009151.3) ENSMUST00000100874.1 ENSMUST00000100874.2 ENSMUST00000100874.3 ENSMUST00000100874.4 ENSMUST00000100874.5 NM_009151 Q3TA56 Q3TA56_MOUSE Selpl Selplg uc033ilg.1 uc033ilg.2 uc033ilg.3 membrane integral component of membrane carbohydrate binding uc033ilg.1 uc033ilg.2 uc033ilg.3 
ENSMUST00000100882.3 Ccdc121rt2 ENSMUST00000100882.3 coiled-coil domain containing 121, retrogene 2 (from RefSeq NM_001177504.1) Ccdc121rt2 E9Q3K0 E9Q3K0_MOUSE ENSMUST00000100882.1 ENSMUST00000100882.2 NM_001177504 uc012ebj.1 uc012ebj.2 molecular_function cellular_component biological_process uc012ebj.1 uc012ebj.2 
ENSMUST00000100886.4 Gm5797 ENSMUST00000100886.4 predicted gene 5797 (from RefSeq NM_001025085.3) EG545013 ENSMUST00000100886.1 ENSMUST00000100886.2 ENSMUST00000100886.3 Gm5797 NM_001025085 Q5BKP9 Q5BKP9_MOUSE uc007sea.1 uc007sea.2 molecular_function cellular_component biological_process uc007sea.1 uc007sea.2 
ENSMUST00000100888.10 Gm16434 ENSMUST00000100888.10 Gm16434 (from geneSymbol) ENSMUST00000100888.1 ENSMUST00000100888.2 ENSMUST00000100888.3 ENSMUST00000100888.4 ENSMUST00000100888.5 ENSMUST00000100888.6 ENSMUST00000100888.7 ENSMUST00000100888.8 ENSMUST00000100888.9 Gm16434 Gm6676 K7N6G4 K7N6G4_MOUSE uc288qpz.1 uc288qpz.2 molecular_function cellular_component biological_process uc288qpz.1 uc288qpz.2 
ENSMUST00000100900.4 Gm16440 ENSMUST00000100900.4 Gm16440 (from geneSymbol) ENSMUST00000100900.1 ENSMUST00000100900.2 ENSMUST00000100900.3 Gm16440 K7N6G6 K7N6G6_MOUSE uc288qon.1 uc288qon.2 molecular_function cellular_component biological_process uc288qon.1 uc288qon.2 
ENSMUST00000100924.5 Lrcol1 ENSMUST00000100924.5 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3URS3-1; Sequence=Displayed; Name=2; IsoId=Q3URS3-2; Sequence=VSP_044127; (from UniProt Q3URS3) AK141249 B9EJP8 Clpsl3 ENSMUST00000100924.1 ENSMUST00000100924.2 ENSMUST00000100924.3 ENSMUST00000100924.4 Gm1679 H9C9P1 LRCL1_MOUSE Q3URS3 uc008yqv.1 uc008yqv.2 uc008yqv.3 uc008yqv.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3URS3-1; Sequence=Displayed; Name=2; IsoId=Q3URS3-2; Sequence=VSP_044127; cellular_component extracellular region digestion enzyme activator activity lipid catabolic process response to food positive regulation of catalytic activity uc008yqv.1 uc008yqv.2 uc008yqv.3 uc008yqv.4 
ENSMUST00000100926.4 Tex52 ENSMUST00000100926.4 testis expressed 52 (from RefSeq NM_027697.1) ENSMUST00000100926.1 ENSMUST00000100926.2 ENSMUST00000100926.3 NM_027697 Q3TTI8 Q9D448 TEX52_MOUSE Tex52 uc009edm.1 uc009edm.2 uc009edm.3 uc009edm.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TTI8-1; Sequence=Displayed; Name=2; IsoId=Q3TTI8-2; Sequence=VSP_034982, VSP_034983; Expressed in Testis. molecular_function cellular_component biological_process uc009edm.1 uc009edm.2 uc009edm.3 uc009edm.4 
ENSMUST00000100944.9 Gm10419 ENSMUST00000100944.9 Gm10419 (from geneSymbol) AK141638 ENSMUST00000100944.1 ENSMUST00000100944.2 ENSMUST00000100944.3 ENSMUST00000100944.4 ENSMUST00000100944.5 ENSMUST00000100944.6 ENSMUST00000100944.7 ENSMUST00000100944.8 uc008yny.1 uc008yny.2 uc008yny.3 uc008yny.4 uc008yny.1 uc008yny.2 uc008yny.3 uc008yny.4 
ENSMUST00000100960.11 Gbp11 ENSMUST00000100960.11 guanylate binding protein 11, transcript variant 1, non-coding (from RefSeq NR_132129.1) ENSMUST00000100960.1 ENSMUST00000100960.10 ENSMUST00000100960.2 ENSMUST00000100960.3 ENSMUST00000100960.4 ENSMUST00000100960.5 ENSMUST00000100960.6 ENSMUST00000100960.7 ENSMUST00000100960.8 ENSMUST00000100960.9 NR_132129 uc290xsh.1 uc290xsh.2 uc290xsh.1 uc290xsh.2 
ENSMUST00000100961.5 Gbp9 ENSMUST00000100961.5 Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. (from UniProt Q8BTS3) AK088861 BC057170 ENSMUST00000100961.1 ENSMUST00000100961.2 ENSMUST00000100961.3 ENSMUST00000100961.4 Gbp9 Q8BTS3 Q8BTS3_MOUSE uc290xry.1 uc290xry.2 Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. nucleotide binding GTPase activity GTP binding symbiont-containing vacuole membrane cytoplasmic vesicle defense response to protozoan adhesion of symbiont to host defense response to Gram-positive bacterium cellular response to interferon-gamma uc290xry.1 uc290xry.2 
ENSMUST00000100962.8 Gbp4 ENSMUST00000100962.8 guanylate binding protein 4, transcript variant 2 (from RefSeq NM_008620.4) A0A0G2JDT5 A0A0G2JEJ5 A0A0G2JGT4 A4UUI3 B9EJ74 ENSMUST00000100962.1 ENSMUST00000100962.2 ENSMUST00000100962.3 ENSMUST00000100962.4 ENSMUST00000100962.5 ENSMUST00000100962.6 ENSMUST00000100962.7 GBP4_MOUSE Gbp4 NM_008620 Q61594 uc008yky.1 uc008yky.2 uc008yky.3 Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:18025219). Negatively regulates the antiviral response by inhibiting activation of IRF7 transcription factor (PubMed:22095711). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; Heterodimer with other family members, including GBP1, GBP2 and GBP5 (By similarity). Dimerization regulates subcellular location (By similarity). Interacts with IRF7; preventing interaction between TRAF6 and IRF7, resulting in impaired TRAF6-mediated IRF7 ubiquitination (PubMed:22095711). Golgi apparatus membrane Cytoplasm Nucleus Cytoplasm, perinuclear region Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A4UUI3-1; Sequence=Displayed; Name=2; IsoId=A4UUI3-2; Sequence=VSP_061850; Mainly expressed in organs of the immune system, such as spleen and lymph nodes. Up-regulated in response to Sendai virus (SeV) infection. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily. negative regulation of transcription from RNA polymerase II promoter nucleotide binding negative regulation of protein phosphorylation GTPase activity protein binding GTP binding symbiont-containing vacuole membrane negative regulation of protein ubiquitination cytoplasmic vesicle negative regulation of interferon-alpha production negative regulation of protein import into nucleus defense response to protozoan regulation of defense response to virus defense response to Gram-positive bacterium cellular response to interferon-gamma uc008yky.1 uc008yky.2 uc008yky.3 
ENSMUST00000100968.4 Vmn2r27 ENSMUST00000100968.4 vomeronasal 2, receptor27 (from RefSeq NM_001104642.1) D3YUK6 D3YUK6_MOUSE ENSMUST00000100968.1 ENSMUST00000100968.2 ENSMUST00000100968.3 NM_001104642 Vmn2r27 uc009veb.1 uc009veb.2 uc009veb.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009veb.1 uc009veb.2 uc009veb.3 
ENSMUST00000100993.9 Cecr2 ENSMUST00000100993.9 CECR2, histone acetyl-lysine reader, transcript variant 2 (from RefSeq NM_001368706.1) CECR2_MOUSE Cecr2 E9Q2Z1 E9QA25 ENSMUST00000100993.1 ENSMUST00000100993.2 ENSMUST00000100993.3 ENSMUST00000100993.4 ENSMUST00000100993.5 ENSMUST00000100993.6 ENSMUST00000100993.7 ENSMUST00000100993.8 F6VR46 F7B218 Kiaa1740 NM_001368706 Q6PAQ2 Q6ZPI9 uc291ikr.1 uc291ikr.2 Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (By similarity). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (By similarity). The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex (By similarity). Plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development (PubMed:15640247, PubMed:20589882, PubMed:21246654). In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (PubMed:22154806). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (By similarity). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (By similarity). Component of the CERF-1 ISWI chromatin remodeling complex (also called the CECR2-containing remodeling factor (CERF) complex) at least composed of CECR2 and SMARCA1 (By similarity). Component of the CERF-5 ISWI chromatin remodeling complex at least composed of SMARCA5/SNF2H and CECR2 (By similarity). Within the CERF-1 and CERF-5 ISWI chromatin remodeling complexes interacts with SMARCA1 and SMARCA5/SNF2H, respectively (By similarity). Interacts with acetylated lysine residues on histone H2A and H3 (in vitro) (By similarity). Interacts with LRPPRC (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q2Z1-1; Sequence=Displayed; Name=2; IsoId=E9Q2Z1-2; Sequence=VSP_059110; In embryos, predominantly expressed in neural tissues (PubMed:15640247). Expressed throughout inner ear development: expressed in the neuroepithelium, head mesenchyme and the cochlear floor (PubMed:21246654). The Bromo domain recognizes and binds acetylated histones. Also recognizes and binds histones that are butyrylated. Perinatal death with high penetrance due to cranial neural tube defects (PubMed:15640247, PubMed:20589882). Exencephaly is frequently associated by open eyelids (PubMed:20589882). Defects may be due to misregulation of mesenchymal/ectodermal transcription factors (PubMed:20589882). Fetuses also show specific inner ear defects, such as smaller cochleae as well as rotational defects of sensory cells and extra cell rows in the inner ear reminiscent of planar cell polarity (PCP) mutants (PubMed:21246654). Mutant males non-penetrant for neural tube defects produce smaller litters: mutants have normal seminiferous epithelium morphology, sperm count, motility and morphology, but the mutant spermatozoa are compromised in their ability to fertilize oocytes (PubMed:22154806). neural fold formation neural tube closure molecular_function nucleus nuclear euchromatin chromatin organization single fertilization neural tube development ISWI-type complex ATP-dependent chromatin remodeling inner ear receptor stereocilium organization cochlea development CERF complex execution phase of apoptosis uc291ikr.1 uc291ikr.2 
ENSMUST00000101007.4 9330160F10Rik ENSMUST00000101007.4 9330160F10Rik (from geneSymbol) AK162406 ENSMUST00000101007.1 ENSMUST00000101007.2 ENSMUST00000101007.3 uc287zev.1 uc287zev.2 uc287zev.3 uc287zev.1 uc287zev.2 uc287zev.3 
ENSMUST00000101015.10 Pramel47 ENSMUST00000101015.10 PRAME like 47 (from RefSeq NM_001270456.1) D3YUK0 D3YUK0_MOUSE ENSMUST00000101015.1 ENSMUST00000101015.2 ENSMUST00000101015.3 ENSMUST00000101015.4 ENSMUST00000101015.5 ENSMUST00000101015.6 ENSMUST00000101015.7 ENSMUST00000101015.8 ENSMUST00000101015.9 NM_001270456 Pramel47 uc290xgg.1 uc290xgg.2 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xgg.1 uc290xgg.2 
ENSMUST00000101018.11 Cep170b ENSMUST00000101018.11 centrosomal protein 170B, transcript variant 1 (from RefSeq NM_001024602.4) C170B_MOUSE ENSMUST00000101018.1 ENSMUST00000101018.10 ENSMUST00000101018.2 ENSMUST00000101018.3 ENSMUST00000101018.4 ENSMUST00000101018.5 ENSMUST00000101018.6 ENSMUST00000101018.7 ENSMUST00000101018.8 ENSMUST00000101018.9 Kiaa0284 NM_001024602 Q3UH33 Q3UHG1 Q80U49 Q80UM2 uc007pfb.1 uc007pfb.2 uc007pfb.3 Plays a role in microtubule organization. Cytoplasm, cytoskeleton Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80U49-1; Sequence=Displayed; Name=2; IsoId=Q80U49-2; Sequence=VSP_024249; Belongs to the CEP170 family. Sequence=BAC65518.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component cytoplasm cytoskeleton microtubule biological_process uc007pfb.1 uc007pfb.2 uc007pfb.3 
ENSMUST00000101029.4 Inf2 ENSMUST00000101029.4 inverted formin, FH2 and WH2 domain containing, transcript variant 1 (from RefSeq NM_198411.3) E9QLA5 E9QLA5_MOUSE ENSMUST00000101029.1 ENSMUST00000101029.2 ENSMUST00000101029.3 Inf2 NM_198411 uc007pes.1 uc007pes.2 uc007pes.3 actin binding cellular component organization Rho GTPase binding actin cytoskeleton organization perinuclear region of cytoplasm regulation of mitochondrial fission uc007pes.1 uc007pes.2 uc007pes.3 
ENSMUST00000101044.9 Atp2b2 ENSMUST00000101044.9 ATPase, Ca++ transporting, plasma membrane 2, transcript variant 9 (from RefSeq NM_001409534.1) Atp2b2 ENSMUST00000101044.1 ENSMUST00000101044.2 ENSMUST00000101044.3 ENSMUST00000101044.4 ENSMUST00000101044.5 ENSMUST00000101044.6 ENSMUST00000101044.7 ENSMUST00000101044.8 F8WHB1 F8WHB1_MOUSE NM_001409534 uc009dho.1 uc009dho.2 uc009dho.3 Catalyzes the hydrolysis of ATP coupled with the transport of calcium. Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.10; Evidence=; Membrane ulti-pass membrane protein Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. nucleotide binding calcium-transporting ATPase activity ATP binding cytoplasm ion transport calcium ion transport sensory perception of sound membrane integral component of membrane neuron differentiation regulation of cytosolic calcium ion concentration calcium ion transmembrane transport presynapse postsynapse glutamatergic synapse GABA-ergic synapse regulation of presynaptic cytosolic calcium ion concentration regulation of postsynaptic cytosolic calcium ion concentration calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration uc009dho.1 uc009dho.2 uc009dho.3 
ENSMUST00000101049.9 Elac2 ENSMUST00000101049.9 elaC ribonuclease Z 2, transcript variant 4 (from RefSeq NM_001362984.1) B1ATP6 ENSMUST00000101049.1 ENSMUST00000101049.2 ENSMUST00000101049.3 ENSMUST00000101049.4 ENSMUST00000101049.5 ENSMUST00000101049.6 ENSMUST00000101049.7 ENSMUST00000101049.8 NM_001362984 Q80Y81 Q99MF0 Q99MF1 Q9CTA2 Q9D1A8 Q9EPZ2 RNZ2_MOUSE uc287yze.1 uc287yze.2 Zinc phosphodiesterase, which displays mitochondrial tRNA 3'- processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. Reaction=Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.; EC=3.1.26.11; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Homodimer. Interacts with PTCD1. Mitochondrion Mitochondrion matrix, mitochondrion nucleoid Nucleus Note=Mainly mitochondrial. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80Y81-1; Sequence=Displayed; Name=2; IsoId=Q80Y81-2; Sequence=VSP_009173; Belongs to the RNase Z family. nuclease activity endonuclease activity tRNA-specific ribonuclease activity nucleus nucleoplasm mitochondrion tRNA processing hydrolase activity mitochondrial nucleoid metal ion binding mitochondrial tRNA 3'-trailer cleavage, endonucleolytic uc287yze.1 uc287yze.2 
ENSMUST00000101056.8 Prr27 ENSMUST00000101056.8 proline rich 27, transcript variant 1 (from RefSeq NM_001163551.1) 4930432K09Rik ENSMUST00000101056.1 ENSMUST00000101056.2 ENSMUST00000101056.3 ENSMUST00000101056.4 ENSMUST00000101056.5 ENSMUST00000101056.6 ENSMUST00000101056.7 NM_001163551 Prr27 Q3SYJ2 Q3SYJ2_MOUSE uc008xzb.1 uc008xzb.2 uc008xzb.3 molecular_function biological_process uc008xzb.1 uc008xzb.2 uc008xzb.3 
ENSMUST00000101059.4 Prrt3 ENSMUST00000101059.4 proline-rich transmembrane protein 3, transcript variant 3 (from RefSeq NM_172487.4) ENSMUST00000101059.1 ENSMUST00000101059.2 ENSMUST00000101059.3 NM_172487 PRRT3_MOUSE Q6PE13 uc009dgp.1 uc009dgp.2 uc009dgp.3 uc009dgp.4 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009dgp.1 uc009dgp.2 uc009dgp.3 uc009dgp.4 
ENSMUST00000101070.5 Jagn1 ENSMUST00000101070.5 jagunal homolog 1, transcript variant 1 (from RefSeq NM_026365.3) ENSMUST00000101070.1 ENSMUST00000101070.2 ENSMUST00000101070.3 ENSMUST00000101070.4 JAGN1_MOUSE Jagn1 NM_026365 Q5XKN4 Q9CQ67 Q9CX52 uc009dgf.1 uc009dgf.2 uc009dgf.3 Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils. Interacts with COPA, COPB2 and COPG2. Endoplasmic reticulum membrane ; Multi-pass membrane protein Lethality around embryonic day 8.5. Mice carrying a hematopoietic lineage-specific deletion of Jagn1 show defects in neutrophil-dependent immune response to the fungal pathogen Candida albicans. Neutrophils display defects in the glycosylation of proteins involved in cell adhesion and cytotoxicity as well as impaired migration in response to Candida albicans infection and impaired formation of cytotoxic granules. Belongs to the jagunal family. Experiments in human confirm the importance of JAGN1 in neutrophil function with some differences. Defects in JAGN1 cause neutropenia in human, while it is not the case in mice lacking Jagn1. Mutant mice show defects in neutrophil migration and increased susceptibility to fungal infections due to defective killing capacity of neutrophil granulocytes. Sequence=BAB32013.1; Type=Frameshift; Evidence=; immune system process neutrophil mediated immunity molecular_function endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum organization protein transport membrane integral component of membrane vesicle-mediated transport granulocyte colony-stimulating factor signaling pathway defense response to fungus negative regulation of insulin secretion involved in cellular response to glucose stimulus cellular response to tunicamycin neutrophil migration neutrophil differentiation uc009dgf.1 uc009dgf.2 uc009dgf.3 
ENSMUST00000101073.3 Tmprss11a ENSMUST00000101073.3 transmembrane protease, serine 11a (from RefSeq NM_001033233.2) Desc3 ENSMUST00000101073.1 ENSMUST00000101073.2 Gm7 Hatl1 NM_001033233 Q3UQ41 TM11A_MOUSE uc008xxq.1 uc008xxq.2 Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest. Membrane ; Single-pass type II membrane protein Belongs to the peptidase S1 family. serine-type endopeptidase activity extracellular region integral component of plasma membrane proteolysis cell cycle peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity proteolysis in other organism viral entry into host cell uc008xxq.1 uc008xxq.2 
ENSMUST00000101078.12 Serpina3m ENSMUST00000101078.12 Secreted (from UniProt Q03734) E9Q926 ENSMUST00000101078.1 ENSMUST00000101078.10 ENSMUST00000101078.11 ENSMUST00000101078.2 ENSMUST00000101078.3 ENSMUST00000101078.4 ENSMUST00000101078.5 ENSMUST00000101078.6 ENSMUST00000101078.7 ENSMUST00000101078.8 ENSMUST00000101078.9 Q03734 Q62260 SPA3M_MOUSE X55148 uc288ixg.1 uc288ixg.2 Secreted Expressed in liver and testis. The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity. The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 14 individual murine paralogs. Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular region extracellular space negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to cytokine response to peptide hormone uc288ixg.1 uc288ixg.2 
ENSMUST00000101087.10 Srp72 ENSMUST00000101087.10 signal recognition particle 72 (from RefSeq NM_025691.1) ENSMUST00000101087.1 ENSMUST00000101087.2 ENSMUST00000101087.3 ENSMUST00000101087.4 ENSMUST00000101087.5 ENSMUST00000101087.6 ENSMUST00000101087.7 ENSMUST00000101087.8 ENSMUST00000101087.9 F8VQC1 F8VQC1_MOUSE NM_025691 Srp72 uc008xvp.1 uc008xvp.2 uc008xvp.3 Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Cytoplasm doplasmic reticulum Belongs to the SRP72 family. signal recognition particle binding nucleolus cytoplasm endoplasmic reticulum signal recognition particle, endoplasmic reticulum targeting SRP-dependent cotranslational protein targeting to membrane 7S RNA binding TPR domain binding response to drug ribosome binding signal recognition particle uc008xvp.1 uc008xvp.2 uc008xvp.3 
ENSMUST00000101102.2 Reps2 ENSMUST00000101102.2 RALBP1 associated Eps domain containing protein 2, transcript variant 1 (from RefSeq NM_178256.5) B9EI38 B9EI38_MOUSE ENSMUST00000101102.1 NM_178256 Reps2 uc009uue.1 uc009uue.2 uc009uue.3 uc009uue.4 calcium ion binding uc009uue.1 uc009uue.2 uc009uue.3 uc009uue.4 
ENSMUST00000101118.4 Rybp ENSMUST00000101118.4 RING1 and YY1 binding protein (from RefSeq NM_019743.3) B2RRB6 Dedaf ENSMUST00000101118.1 ENSMUST00000101118.2 ENSMUST00000101118.3 NM_019743 Q8CCI5 Q9WVK2 RYBP_MOUSE uc009dbw.1 uc009dbw.2 uc009dbw.3 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:22325148, PubMed:28596365). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365). May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (PubMed:22325148, PubMed:28596365). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (By similarity). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:17874297). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (By similarity). May bind to DNA (PubMed:19170609). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). Monomer. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2 (By similarity). Component of PCR1-like complexes (PubMed:22325148, PubMed:28596365). Interacts with PCGF1. Part of a PCR1-like complex that contains AUTS2, PCGF5, RNF2, CSNK2B and RYBP. Interacts with RNF2; the interaction is direct (By similarity). Interacts with CBX2, YAF2, RING1 and RNF2 (PubMed:10369680, PubMed:19170609, PubMed:22226355). Interacts with ubiquitin and ubiquitinated proteins (PubMed:17070805). Interacts with ubiquitinated histone H2A (PubMed:17070805). Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and GABPB1. Together with GABPB1 and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors. Interacts with MDM2, and thereby inhibits ubiquitination of TP53. Identified in a ternary complex containing MDM2, TP53 and RYBP. Interacts with FANK1; may prevent the ubiquitin- mediated proteasomal degradation of FANK1 (By similarity). Interacts with IFT57 (PubMed:17874297). Q8CCI5; P30658: Cbx2; NbExp=3; IntAct=EBI-929290, EBI-360174; Q8CCI5; O35730: Ring1; NbExp=4; IntAct=EBI-929290, EBI-929310; Q8CCI5; Q9CQJ4: Rnf2; NbExp=8; IntAct=EBI-929290, EBI-927321; Q8CCI5; P25490: YY1; Xeno; NbExp=2; IntAct=EBI-929290, EBI-765538; Nucleus Cytoplasm Nucleus, nucleoplasm Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies. Expressed in embryonic stem cells. At 9.0 dpc, selectively expressed in cells of the developing nervous system and from day E.5 onwards, expressed ubiquitously. Intrinsically unstructured in the absence of binding partners. Folds upon binding to DNA or RNF2. Monoubiquitinated. Embryonically lethal. Embryos die at early postimplantation stage. Sequence=AAD42945.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter DNA binding transcription corepressor activity protein binding nucleus nucleoplasm cytoplasm apoptotic process PcG protein complex negative regulation of proteasomal ubiquitin-dependent protein catabolic process histone H2A monoubiquitination positive regulation of apoptotic process positive regulation of transcription, DNA-templated metal ion binding uc009dbw.1 uc009dbw.2 uc009dbw.3 
ENSMUST00000101120.11 Prok2 ENSMUST00000101120.11 prokineticin 2, transcript variant 2 (from RefSeq NM_001037539.3) B7ZMX7 Bv8 ENSMUST00000101120.1 ENSMUST00000101120.10 ENSMUST00000101120.2 ENSMUST00000101120.3 ENSMUST00000101120.4 ENSMUST00000101120.5 ENSMUST00000101120.6 ENSMUST00000101120.7 ENSMUST00000101120.8 ENSMUST00000101120.9 NM_001037539 PROK2_MOUSE Q9QXU5 Q9QXU6 Q9QXU7 uc009dbu.1 uc009dbu.2 May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle (By similarity). Secreted. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Bv8-a; IsoId=Q9QXU7-1; Sequence=Displayed; Name=2; Synonyms=Bv8-b; IsoId=Q9QXU7-2; Sequence=VSP_005220; Name=3; IsoId=Q9QXU7-3; Sequence=VSP_005221; Expressed in the SCN and among a few other discrete brain areas, including the islands of Calleja, media l preoptic area of the hypothalamus and the shell of the nucleus accumbens. Highly expressed in testis. In the SCN, expression subjected to high amplitude of circadian oscillation. Expressed in mid-late pachytene spermatocytes at the stages VII, VIII and IX of the semiferous epithelial cycle. Activated by CLOCK and BMAL1 heterodimers and light; inhibited by period genes (PER1, PER2 and PER3) and cryptochrome genes (CRY1 and CRY2). Belongs to the AVIT (prokineticin) family. activation of MAPK activity angiogenesis G-protein coupled receptor binding epicardium-derived cardiac endothelial cell differentiation extracellular region chemotaxis neuropeptide signaling pathway spermatogenesis circadian rhythm cell proliferation positive regulation of cell proliferation negative regulation of apoptotic process regulation of angiogenesis positive regulation of smooth muscle contraction rhythmic process coronary vasculature development vasculogenesis involved in coronary vascular morphogenesis epicardium-derived cardiac vascular smooth muscle cell differentiation uc009dbu.1 uc009dbu.2 
ENSMUST00000101121.3 Gm6116 ENSMUST00000101121.3 predicted gene 6116 (from RefSeq NR_045866.1) ENSMUST00000101121.1 ENSMUST00000101121.2 NR_045866 uc029vir.1 uc029vir.2 uc029vir.3 uc029vir.1 uc029vir.2 uc029vir.3 
ENSMUST00000101122.3 Gpr27 ENSMUST00000101122.3 G protein-coupled receptor 27 (from RefSeq NM_008158.2) ENSMUST00000101122.1 ENSMUST00000101122.2 GPR27_MOUSE NM_008158 O54897 Sreb1 uc009dbs.1 uc009dbs.2 uc009dbs.3 Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity). Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway uc009dbs.1 uc009dbs.2 uc009dbs.3 
ENSMUST00000101127.12 Fryl ENSMUST00000101127.12 FRY like transcription coactivator (from RefSeq NM_028194.2) ENSMUST00000101127.1 ENSMUST00000101127.10 ENSMUST00000101127.11 ENSMUST00000101127.2 ENSMUST00000101127.3 ENSMUST00000101127.4 ENSMUST00000101127.5 ENSMUST00000101127.6 ENSMUST00000101127.7 ENSMUST00000101127.8 ENSMUST00000101127.9 F8VQ05 F8VQ05_MOUSE Fryl NM_028194 uc008xsn.1 uc008xsn.2 uc008xsn.3 cell morphogenesis cell cortex neuron projection development uc008xsn.1 uc008xsn.2 uc008xsn.3 
ENSMUST00000101137.3 Samt2 ENSMUST00000101137.3 spermatogenesis associated multipass transmembrane protein 2 (from RefSeq NM_001037167.1) EG434881 ENSMUST00000101137.1 ENSMUST00000101137.2 Gm5647 NM_001037167 Q497M0 Q497M0_MOUSE Samt2 uc009uri.1 uc009uri.2 uc009uri.3 Cell junction, tight junction Belongs to the claudin family. molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc009uri.1 uc009uri.2 uc009uri.3 
ENSMUST00000101141.9 Shroom2 ENSMUST00000101141.9 shroom family member 2, transcript variant 1 (from RefSeq NM_172441.3) A7TU71 A7TU71_MOUSE ENSMUST00000101141.1 ENSMUST00000101141.2 ENSMUST00000101141.3 ENSMUST00000101141.4 ENSMUST00000101141.5 ENSMUST00000101141.6 ENSMUST00000101141.7 ENSMUST00000101141.8 NM_172441 Shroom2 uc009uql.1 uc009uql.2 uc009uql.3 uc009uql.4 Cytoplasm, cytoskeleton Belongs to the shroom family. actin binding cortical actin cytoskeleton establishment of melanosome localization apical protein localization actin filament binding uc009uql.1 uc009uql.2 uc009uql.3 uc009uql.4 
ENSMUST00000101153.10 Iqsec1 ENSMUST00000101153.10 IQ motif and Sec7 domain 1, transcript variant 16 (from RefSeq NM_001408955.1) ENSMUST00000101153.1 ENSMUST00000101153.2 ENSMUST00000101153.3 ENSMUST00000101153.4 ENSMUST00000101153.5 ENSMUST00000101153.6 ENSMUST00000101153.7 ENSMUST00000101153.8 ENSMUST00000101153.9 IQEC1_MOUSE Kiaa0763 NM_001408955 Q3TZC3 Q5DU15 Q8R0S2 uc009cxq.1 uc009cxq.2 uc009cxq.3 uc009cxq.4 Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (By similarity). Involved in neuronal development (PubMed:31607425). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). Interacts with ARF1 and ARF6. Interacts with GRIA2; the interaction is required for ARF6 activation. Cytoplasm Nucleus Postsynaptic density Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Note=At steady state, may be preferentially cytosolic. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R0S2-1; Sequence=Displayed; Name=2; IsoId=Q8R0S2-2; Sequence=VSP_019759; Expressed in hippocampus. Expression is first detected at postanatal day P7 and increases until P42 (at protein level). The PH domain mediates interaction with lipid membranes that contain phosphatidylinositol-4,5-bisphosphate, but does not bind membranes that lack phosphatidylinositol-4,5-bisphosphate. Mice with a conditional knockout in cortical neurons exhibit an increased density of dendritic spines with an immature morphology. Belongs to the BRAG family. guanyl-nucleotide exchange factor activity ARF guanyl-nucleotide exchange factor activity nucleus nucleolus cytoplasm lipid binding protein kinase binding actin cytoskeleton organization regulation of ARF protein signal transduction intracellular membrane-bounded organelle positive regulation of GTPase activity positive regulation of keratinocyte migration glutamatergic synapse postsynaptic density, intracellular component positive regulation of adherens junction organization uc009cxq.1 uc009cxq.2 uc009cxq.3 uc009cxq.4 
ENSMUST00000101162.4 Gm10435 ENSMUST00000101162.4 Gm10435 (from geneSymbol) ENSMUST00000101162.1 ENSMUST00000101162.2 ENSMUST00000101162.3 uc287ylw.1 uc287ylw.2 uc287ylw.1 uc287ylw.2 
ENSMUST00000101164.11 Limch1 ENSMUST00000101164.11 LIM and calponin homology domains 1, transcript variant 11 (from RefSeq NM_001401417.1) ENSMUST00000101164.1 ENSMUST00000101164.10 ENSMUST00000101164.2 ENSMUST00000101164.3 ENSMUST00000101164.4 ENSMUST00000101164.5 ENSMUST00000101164.6 ENSMUST00000101164.7 ENSMUST00000101164.8 ENSMUST00000101164.9 Kiaa1102 LIMC1_MOUSE Limch1 NM_001401417 Q3UH68 Q6DIC3 Q80TK1 uc008xph.1 uc008xph.2 uc008xph.3 Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Interacts with MYH9; independently of the integration of MYH9 into the myosin complex. Cytoplasm, cytoskeleton, stress fiber Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UH68-1; Sequence=Displayed; Name=2; IsoId=Q3UH68-2; Sequence=VSP_026551, VSP_026553; Name=3; IsoId=Q3UH68-3; Sequence=VSP_026552, VSP_026554; Belongs to the LIMCH1 family. stress fiber positive regulation of protein phosphorylation actin binding cytoplasm cytoskeleton negative regulation of cell migration actomyosin structure organization myosin II head/neck binding metal ion binding positive regulation of stress fiber assembly regulation of focal adhesion assembly myosin II complex uc008xph.1 uc008xph.2 uc008xph.3 
ENSMUST00000101165.9 Adck1 ENSMUST00000101165.9 aarF domain containing kinase 1, transcript variant 7 (from RefSeq NM_001361601.1) ADCK1_MOUSE ENSMUST00000101165.1 ENSMUST00000101165.2 ENSMUST00000101165.3 ENSMUST00000101165.4 ENSMUST00000101165.5 ENSMUST00000101165.6 ENSMUST00000101165.7 ENSMUST00000101165.8 NM_001361601 Q3UKJ2 Q9D0L4 uc007oju.1 uc007oju.2 uc007oju.3 uc007oju.4 Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase- independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT (By similarity). The action of this enzyme is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable). Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D0L4-1; Sequence=Displayed; Name=2; IsoId=Q9D0L4-2; Sequence=VSP_020886; Belongs to the protein kinase superfamily. ADCK protein kinase family. nucleotide binding molecular_function protein kinase activity protein serine/threonine kinase activity ATP binding extracellular region mitochondrion protein phosphorylation biological_process kinase activity phosphorylation transferase activity uc007oju.1 uc007oju.2 uc007oju.3 uc007oju.4 
ENSMUST00000101168.4 Eif1ad7 ENSMUST00000101168.4 eukaryotic translation initiation factor 1A domain containing 7 (from RefSeq NM_001013824.3) EG435337 ENSMUST00000101168.1 ENSMUST00000101168.2 ENSMUST00000101168.3 Eif1ad7 Gm5662 NM_001013824 Q8BX20 Q8BX20_MOUSE uc007ojs.1 uc007ojs.2 uc007ojs.3 uc007ojs.4 uc007ojs.5 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. molecular_function RNA binding translation initiation factor activity cellular_component translation translational initiation biological_process uc007ojs.1 uc007ojs.2 uc007ojs.3 uc007ojs.4 uc007ojs.5 
ENSMUST00000101180.8 Gm15097 ENSMUST00000101180.8 predicted gene 15097 (from RefSeq NM_001198987.2) ENSMUST00000101180.1 ENSMUST00000101180.2 ENSMUST00000101180.3 ENSMUST00000101180.4 ENSMUST00000101180.5 ENSMUST00000101180.6 ENSMUST00000101180.7 Gm15097 L7MU67 L7MU67_MOUSE NM_001198987 uc012hqj.1 uc012hqj.2 uc012hqj.3 uc012hqj.4 uc012hqj.5 molecular_function cellular_component biological_process uc012hqj.1 uc012hqj.2 uc012hqj.3 uc012hqj.4 uc012hqj.5 
ENSMUST00000101181.5 Gm10439 ENSMUST00000101181.5 predicted gene 10439 (from RefSeq NM_001037716.2) A2AJU2 A2AJU2_MOUSE ENSMUST00000101181.1 ENSMUST00000101181.2 ENSMUST00000101181.3 ENSMUST00000101181.4 Gm10439 NM_001037716 uc009uod.1 uc009uod.2 uc009uod.3 molecular_function cellular_component biological_process uc009uod.1 uc009uod.2 uc009uod.3 
ENSMUST00000101186.10 Gm15127 ENSMUST00000101186.10 predicted gene 15127 (from RefSeq NM_001114400.2) B1AVZ5 B1AVZ5_MOUSE ENSMUST00000101186.1 ENSMUST00000101186.2 ENSMUST00000101186.3 ENSMUST00000101186.4 ENSMUST00000101186.5 ENSMUST00000101186.6 ENSMUST00000101186.7 ENSMUST00000101186.8 ENSMUST00000101186.9 Gm15127 NM_001114400 uc029xnk.1 uc029xnk.2 uc029xnk.3 molecular_function cellular_component biological_process uc029xnk.1 uc029xnk.2 uc029xnk.3 
ENSMUST00000101191.10 Klhl5 ENSMUST00000101191.10 kelch-like 5, transcript variant 1 (from RefSeq NM_175174.4) ENSMUST00000101191.1 ENSMUST00000101191.2 ENSMUST00000101191.3 ENSMUST00000101191.4 ENSMUST00000101191.5 ENSMUST00000101191.6 ENSMUST00000101191.7 ENSMUST00000101191.8 ENSMUST00000101191.9 Klhl5 NM_175174 Q6PFE1 Q6PFE1_MOUSE uc008xnc.1 uc008xnc.2 uc008xnc.3 uc008xnc.4 molecular_function cellular_component biological_process uc008xnc.1 uc008xnc.2 uc008xnc.3 uc008xnc.4 
ENSMUST00000101205.3 Col4a6 ENSMUST00000101205.3 collagen, type IV, alpha 6 (from RefSeq NM_053185.3) B1AVK5 B1AVK5_MOUSE Col4a6 ENSMUST00000101205.1 ENSMUST00000101205.2 NM_053185 uc012hpp.1 uc012hpp.2 Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Membrane Secreted, extracellular space, extracellular matrix, basement membrane extracellular matrix structural constituent collagen trimer collagen type IV trimer basement membrane extracellular space extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix collagen-activated tyrosine kinase receptor signaling pathway cellular response to amino acid stimulus uc012hpp.1 uc012hpp.2 
ENSMUST00000101208.6 Sod3 ENSMUST00000101208.6 superoxide dismutase 3, extracellular (from RefSeq NM_011435.3) ENSMUST00000101208.1 ENSMUST00000101208.2 ENSMUST00000101208.3 ENSMUST00000101208.4 ENSMUST00000101208.5 NM_011435 Q542X9 Q542X9_MOUSE Sod3 uc008xkl.1 uc008xkl.2 uc008xkl.3 Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18421; EC=1.15.1.1; Evidence=; Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Note=Binds 1 copper ion per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Belongs to the Cu-Zn superoxide dismutase family. superoxide dismutase activity superoxide metabolic process oxidoreductase activity removal of superoxide radicals metal ion binding oxidation-reduction process uc008xkl.1 uc008xkl.2 uc008xkl.3 
ENSMUST00000101212.9 Nup62cl ENSMUST00000101212.9 nucleoporin 62 C-terminal like (from RefSeq NM_001081668.1) A2AG10 A2AG10_MOUSE ENSMUST00000101212.1 ENSMUST00000101212.2 ENSMUST00000101212.3 ENSMUST00000101212.4 ENSMUST00000101212.5 ENSMUST00000101212.6 ENSMUST00000101212.7 ENSMUST00000101212.8 NM_001081668 Nup62cl uc009ukv.1 uc009ukv.2 uc009ukv.3 uc009ukv.4 Belongs to the nucleoporin NSP1/NUP62 family. phospholipid binding nuclear pore protein import into nucleus structural constituent of nuclear pore nuclear pore central transport channel uc009ukv.1 uc009ukv.2 uc009ukv.3 uc009ukv.4 
ENSMUST00000101213.9 Acsl6 ENSMUST00000101213.9 acyl-CoA synthetase long-chain family member 6, transcript variant 4 (from RefSeq NM_001033599.1) Acsl6 ENSMUST00000101213.1 ENSMUST00000101213.2 ENSMUST00000101213.3 ENSMUST00000101213.4 ENSMUST00000101213.5 ENSMUST00000101213.6 ENSMUST00000101213.7 ENSMUST00000101213.8 NM_001033599 Q5ICG5 Q5ICG5_MOUSE uc007ixt.1 uc007ixt.2 uc007ixt.3 Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:456215; EC=6.2.1.15; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19714; Evidence= Reaction=(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:36139, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61526, ChEBI:CHEBI:72745, ChEBI:CHEBI:456215; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36140; Evidence= Reaction=12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12- hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52112, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:90718, ChEBI:CHEBI:136408, ChEBI:CHEBI:456215; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52113; Evidence= Reaction=15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15- hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52116, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:78832, ChEBI:CHEBI:136409, ChEBI:CHEBI:456215; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52117; Evidence= Reaction=5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5- hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52108, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65341, ChEBI:CHEBI:136407, ChEBI:CHEBI:456215; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52109; Evidence= Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl- CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:456215; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30752; Evidence= Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl- CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422; Evidence=; Endoplasmic reticulum membrane ; Single-pass type III membrane protein Membrane ; Single-pass type III membrane protein Mitochondrion outer membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Mitochondrion outer membrane ; Single-pass type III membrane protein Belongs to the ATP-dependent AMP-binding enzyme family. catalytic activity membrane integral component of membrane uc007ixt.1 uc007ixt.2 uc007ixt.3 
ENSMUST00000101217.4 Ripply1 ENSMUST00000101217.4 ripply transcriptional repressor 1 (from RefSeq NM_001037915.2) ENSMUST00000101217.1 ENSMUST00000101217.2 ENSMUST00000101217.3 NM_001037915 Q2WG77 RIPP1_MOUSE Ripply1 uc009ukk.1 uc009ukk.2 uc009ukk.3 uc009ukk.4 Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity). Nucleus Expressed in the anterior presomitic mesoderm and somites of stage E9.5 dpc embryos. Also expressed in tongue, diaphragm and intercostal muscles at 16.5 dpc. The ripply homology domain is required for transcriptional repression. The WRPW motif is required for binding to TLE/GROUCHO proteins. Belongs to the ripply family. negative regulation of transcription from RNA polymerase II promoter somite specification molecular_function nucleus Notch signaling pathway multicellular organism development embryonic pattern specification regulation of gene expression somite rostral/caudal axis specification negative regulation of transcription, DNA-templated bone morphogenesis uc009ukk.1 uc009ukk.2 uc009ukk.3 uc009ukk.4 
ENSMUST00000101237.8 Bst1 ENSMUST00000101237.8 bone marrow stromal cell antigen 1 (from RefSeq NM_009763.3) A0A0R4J190 A0A0R4J190_MOUSE Bst1 ENSMUST00000101237.1 ENSMUST00000101237.2 ENSMUST00000101237.3 ENSMUST00000101237.4 ENSMUST00000101237.5 ENSMUST00000101237.6 ENSMUST00000101237.7 NM_009763 uc008xia.1 uc008xia.2 uc008xia.3 Belongs to the ADP-ribosyl cyclase family. uropod regulation of cell-matrix adhesion NAD+ nucleosidase activity positive regulation of cell proliferation extrinsic component of membrane regulation of actin cytoskeleton organization regulation of inflammatory response regulation of peptidyl-tyrosine phosphorylation regulation of calcium-mediated signaling ADP-ribosyl cyclase activity cyclic ADP-ribose hydrolase regulation of neutrophil chemotaxis uc008xia.1 uc008xia.2 uc008xia.3 
ENSMUST00000101254.9 Ccdc142 ENSMUST00000101254.9 coiled-coil domain containing 142 (from RefSeq NM_001081266.1) CC142_MOUSE ENSMUST00000101254.1 ENSMUST00000101254.2 ENSMUST00000101254.3 ENSMUST00000101254.4 ENSMUST00000101254.5 ENSMUST00000101254.6 ENSMUST00000101254.7 ENSMUST00000101254.8 NM_001081266 Q8CAI1 uc009cmj.1 uc009cmj.2 uc009cmj.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CAI1-1; Sequence=Displayed; Name=2; IsoId=Q8CAI1-2; Sequence=VSP_029500, VSP_029501; molecular_function cellular_component biological_process uc009cmj.1 uc009cmj.2 uc009cmj.3 
ENSMUST00000101269.2 Cpxcr1 ENSMUST00000101269.2 CPX chromosome region, candidate 1 (from RefSeq NM_001033471.3) A2BEE6 B2RW29 CPXCR_MOUSE ENSMUST00000101269.1 Gm1143 NM_001033471 Q3V0P1 uc009uea.1 uc009uea.2 molecular_function cellular_component biological_process uc009uea.1 uc009uea.2 
ENSMUST00000101272.3 Reg3a ENSMUST00000101272.3 regenerating islet-derived 3 alpha (from RefSeq NM_011259.1) ENSMUST00000101272.1 ENSMUST00000101272.2 NM_011259 Q794C6 Q794C6_MOUSE Reg3a uc009cjy.1 uc009cjy.2 uc009cjy.3 carbohydrate binding uc009cjy.1 uc009cjy.2 uc009cjy.3 
ENSMUST00000101281.4 Ppp1r36dn ENSMUST00000101281.4 Ppp1r36dn (from geneSymbol) AK136613 ENSMUST00000101281.1 ENSMUST00000101281.2 ENSMUST00000101281.3 uc007nyh.1 uc007nyh.2 uc007nyh.3 uc007nyh.4 uc007nyh.5 uc007nyh.1 uc007nyh.2 uc007nyh.3 uc007nyh.4 uc007nyh.5 
ENSMUST00000101290.2 Wmp ENSMUST00000101290.2 WAVE homology in membrane protrusions (from RefSeq NM_001033252.2) ENSMUST00000101290.1 Gm732 NM_001033252 Q3V0P9 Q3V0P9_MOUSE Wmp uc009ucl.1 uc009ucl.2 molecular_function actin binding cellular_component cytoskeleton biological_process actin cytoskeleton organization uc009ucl.1 uc009ucl.2 
ENSMUST00000101292.9 Tent5d ENSMUST00000101292.9 terminal nucleotidyltransferase 5D, transcript variant 2 (from RefSeq NM_001271008.1) B1ATX6 B1ATX6_MOUSE ENSMUST00000101292.1 ENSMUST00000101292.2 ENSMUST00000101292.3 ENSMUST00000101292.4 ENSMUST00000101292.5 ENSMUST00000101292.6 ENSMUST00000101292.7 ENSMUST00000101292.8 Fam46d NM_001271008 Tent5d uc033jsa.1 uc033jsa.2 uc033jsa.3 Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, ChEBI:CHEBI:173115; EC=2.7.7.19; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11333; Evidence=; Belongs to the TENT family. cellular_component biological_process RNA adenylyltransferase activity uc033jsa.1 uc033jsa.2 uc033jsa.3 
ENSMUST00000101295.9 9930111J21Rik2 ENSMUST00000101295.9 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. (from UniProt Q5SVP2) 9930111J21Rik2 BC066104 ENSMUST00000101295.1 ENSMUST00000101295.2 ENSMUST00000101295.3 ENSMUST00000101295.4 ENSMUST00000101295.5 ENSMUST00000101295.6 ENSMUST00000101295.7 ENSMUST00000101295.8 Q5SVP2 Q5SVP2_MOUSE uc287xrx.1 uc287xrx.2 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. molecular_function GTP binding cellular_component biological_process membrane uc287xrx.1 uc287xrx.2 
ENSMUST00000101297.4 Gm5127 ENSMUST00000101297.4 predicted gene 5127 (from RefSeq NM_001033541.2) EG331493 ENSMUST00000101297.1 ENSMUST00000101297.2 ENSMUST00000101297.3 Gm5127 NM_001033541 Q3UQH6 Q3UQH6_MOUSE uc009ubv.1 uc009ubv.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity integral component of plasma membrane membrane integral component of membrane positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway uc009ubv.1 uc009ubv.2 
ENSMUST00000101301.10 Immt ENSMUST00000101301.10 inner membrane protein, mitochondrial, transcript variant 10 (from RefSeq NM_001362138.1) ENSMUST00000101301.1 ENSMUST00000101301.2 ENSMUST00000101301.3 ENSMUST00000101301.4 ENSMUST00000101301.5 ENSMUST00000101301.6 ENSMUST00000101301.7 ENSMUST00000101301.8 ENSMUST00000101301.9 MIC60_MOUSE Mic60 NM_001362138 Q66JS4 Q7TNE2 Q8C7V1 Q8CAQ8 Q8CCI0 Q8CDA8 Q9D9F6 uc009chj.1 uc009chj.2 uc009chj.3 uc009chj.4 Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13 (By similarity). This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (By similarity). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex (By similarity). Interacts with MICOS13/MIC13, MICOS10/MIC10, CHCHD6/MIC25, SAMM50 and TMEM11 (By similarity). Interacts with CHCHD3/MIC19 (PubMed:21081504). Interacts with APOO/MIC23/MIC26 and APOOL/MIC27 (By similarity). Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form (PubMed:21081504). Interacts with ARMC1 (By similarity). Interacts with ARMC12 (PubMed:33536340). Mitochondrion inner membrane ; Single-pass membrane protein Mitochondrion Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8CAQ8-1; Sequence=Displayed; Name=2; IsoId=Q8CAQ8-2; Sequence=VSP_007003; Name=3; IsoId=Q8CAQ8-3; Sequence=VSP_007003, VSP_007004, VSP_007005; Name=4; IsoId=Q8CAQ8-4; Sequence=VSP_007003, VSP_013222, VSP_013223; Name=5; IsoId=Q8CAQ8-5; Sequence=VSP_013224; [Isoform 4]: May be due to intron retention. Belongs to the MICOS complex subunit Mic60 family. Sequence=BAB24817.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB24817.1; Type=Frameshift; Evidence=; protein binding mitochondrion mitochondrial inner membrane membrane integral component of membrane cristae formation myelin sheath mitochondrial calcium ion homeostasis MICOS complex uc009chj.1 uc009chj.2 uc009chj.3 uc009chj.4 
ENSMUST00000101339.8 Nhsl2 ENSMUST00000101339.8 NHS like 2, transcript variant 9 (from RefSeq NM_001406050.1) B1AXH1 E9Q0V6 ENSMUST00000101339.1 ENSMUST00000101339.2 ENSMUST00000101339.3 ENSMUST00000101339.4 ENSMUST00000101339.5 ENSMUST00000101339.6 ENSMUST00000101339.7 NHSL2_MOUSE NM_001406050 Nhsl2 uc012hmz.1 uc012hmz.2 Belongs to the NHS family. molecular_function cellular_component cell differentiation uc012hmz.1 uc012hmz.2 
ENSMUST00000101351.6 Atoh1 ENSMUST00000101351.6 atonal bHLH transcription factor 1 (from RefSeq NM_007500.5) ATOH1_MOUSE Ath1 Atoh1 ENSMUST00000101351.1 ENSMUST00000101351.2 ENSMUST00000101351.3 ENSMUST00000101351.4 ENSMUST00000101351.5 NM_007500 P48985 uc009ceb.1 uc009ceb.2 uc009ceb.3 uc009ceb.4 uc009ceb.5 Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription. Efficient DNA binding requires dimerization with another bHLH protein. P48985; Q91YV0: Tcf4; NbExp=2; IntAct=EBI-15659000, EBI-15658970; Nucleus Developing nervous system, and in adult epithelial cells of the gastrointestinal tract. First detected in the cranial ganglions and the dorsal part of the central nervous system on 9.5 dpc (PubMed:7721778). From 10.5 dpc onward, prominently expressed in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by 18 dpc and is undetectable in the adult nervous system (PubMed:7721778). Expressed in the cochlear nucleus at 15.5 dpc (PubMed:17977745). RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding neuron migration DNA binding protein binding nucleus regulation of transcription, DNA-templated Notch signaling pathway multicellular organism development nervous system development axon guidance brain development cerebral cortex development cell differentiation neuron differentiation chromatin DNA binding inner ear morphogenesis auditory receptor cell differentiation auditory receptor cell fate specification auditory receptor cell fate determination negative regulation of apoptotic process sequence-specific DNA binding positive regulation of auditory receptor cell differentiation regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter protein dimerization activity inner ear development positive regulation of inner ear receptor cell differentiation uc009ceb.1 uc009ceb.2 uc009ceb.3 uc009ceb.4 uc009ceb.5 
ENSMUST00000101355.9 Gm5570 ENSMUST00000101355.9 predicted gene 5570 (from RefSeq NR_152156.1) ENSMUST00000101355.1 ENSMUST00000101355.2 ENSMUST00000101355.3 ENSMUST00000101355.4 ENSMUST00000101355.5 ENSMUST00000101355.6 ENSMUST00000101355.7 ENSMUST00000101355.8 NR_152156 uc291eyj.1 uc291eyj.2 uc291eyj.1 uc291eyj.2 
ENSMUST00000101358.3 Gm614 ENSMUST00000101358.3 predicted gene 614, transcript variant 2 (from RefSeq NM_001317221.1) CX065_MOUSE ENSMUST00000101358.1 ENSMUST00000101358.2 NM_001317221 Q3V2K1 uc009txa.1 uc009txa.2 uc009txa.3 uc009txa.4 molecular_function cellular_component biological_process uc009txa.1 uc009txa.2 uc009txa.3 uc009txa.4 
ENSMUST00000101387.4 Hbq1b ENSMUST00000101387.4 hemoglobin, theta 1B (from RefSeq NM_001033981.3) ENSMUST00000101387.1 ENSMUST00000101387.2 ENSMUST00000101387.3 Glnd1 Hbq1b NM_001033981 Q3U0A6 Q3U0A6_MOUSE uc007ijl.1 uc007ijl.2 uc007ijl.3 This gene is one of two mouse theta-globin genes found in the alpha-globin gene cluster on chromosome 11. This gene represents the T1 (or 5') theta-globin gene described in PMIDs 18245844 and 11157800, respectively. [provided by RefSeq, Apr 2009]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK157060.1, BC141224.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Belongs to the globin family. oxygen transporter activity hemoglobin complex oxygen transport oxygen binding heme binding haptoglobin-hemoglobin complex hydrogen peroxide catabolic process organic acid binding metal ion binding cellular oxidant detoxification peroxidase activity haptoglobin binding uc007ijl.1 uc007ijl.2 uc007ijl.3 
ENSMUST00000101388.4 Zxdb ENSMUST00000101388.4 zinc finger, X-linked, duplicated B (from RefSeq NM_001081473.2) A2CE44 ENSMUST00000101388.1 ENSMUST00000101388.2 ENSMUST00000101388.3 NM_001081473 Q3V1M7 Q8CEQ1 ZXDB_MOUSE uc009ttq.1 uc009ttq.2 uc009ttq.3 Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. Self-associates. Interacts with ZXDC and CIITA (By similarity). Nucleus Belongs to the ZXD family. Sequence=BAC25496.1; Type=Frameshift; Evidence=; nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus biological_process positive regulation of transcription, DNA-templated metal ion binding C2H2 zinc finger domain binding uc009ttq.1 uc009ttq.2 uc009ttq.3 
ENSMUST00000101394.5 Chac2 ENSMUST00000101394.5 ChaC, cation transport regulator 2, transcript variant 1 (from RefSeq NM_026527.3) CHAC2_MOUSE Chac2 ENSMUST00000101394.1 ENSMUST00000101394.2 ENSMUST00000101394.3 ENSMUST00000101394.4 NM_026527 Q8R3K5 Q9CQG1 Q9D1T7 uc007iih.1 uc007iih.2 uc007iih.3 uc007iih.4 Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide (PubMed:27913623). Acts specifically on glutathione, but not on other gamma-glutamyl peptides (By similarity). Reaction=glutathione = 5-oxo-L-proline + L-cysteinylglycine; Xref=Rhea:RHEA:47724, ChEBI:CHEBI:57925, ChEBI:CHEBI:58402, ChEBI:CHEBI:61694; EC=4.3.2.7; Evidence=; Kinetic parameters: KM=3 mM for glutathione ; Note=kcat is 7.6 min(-1) for glutathione. ; Monomer. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQG1-1; Sequence=Displayed; Name=2; IsoId=Q9CQG1-2; Sequence=VSP_030429; Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily. gamma-glutamylcyclotransferase activity cytoplasm cytosol glutathione catabolic process lyase activity uc007iih.1 uc007iih.2 uc007iih.3 uc007iih.4 
ENSMUST00000101395.3 Hoxa4 ENSMUST00000101395.3 homeobox A4 (from RefSeq NM_008265.4) A0A0R4J193 A0A0R4J193_MOUSE ENSMUST00000101395.1 ENSMUST00000101395.2 Hoxa4 NM_008265 uc009byf.1 uc009byf.2 uc009byf.3 Nucleus Belongs to the Antp homeobox family. Deformed subfamily. DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development nuclear body sequence-specific DNA binding uc009byf.1 uc009byf.2 uc009byf.3 
ENSMUST00000101396.3 Mageb6b2 ENSMUST00000101396.3 Mageb6b2 (from geneSymbol) A2AHM1 A2AHM1_MOUSE ENSMUST00000101396.1 ENSMUST00000101396.2 Gm5072 Gm8914 Mageb6b1 Mageb6b2 uc292pjn.1 uc292pjn.2 molecular_function cellular_component biological_process uc292pjn.1 uc292pjn.2 
ENSMUST00000101411.6 Gm29609 ENSMUST00000101411.6 Nucleus (from UniProt Q3UU56) AK138760 ENSMUST00000101411.1 ENSMUST00000101411.2 ENSMUST00000101411.3 ENSMUST00000101411.4 ENSMUST00000101411.5 Gm29609 Q3UU56 Q3UU56_MOUSE uc008wxg.1 uc008wxg.2 uc008wxg.3 Nucleus transcription factor TFIIIC complex transcription from RNA polymerase III promoter transcription factor activity, core RNA polymerase III binding uc008wxg.1 uc008wxg.2 uc008wxg.3 
ENSMUST00000101426.11 Tmem176a ENSMUST00000101426.11 transmembrane protein 176A, transcript variant 1 (from RefSeq NM_025326.4) ENSMUST00000101426.1 ENSMUST00000101426.10 ENSMUST00000101426.2 ENSMUST00000101426.3 ENSMUST00000101426.4 ENSMUST00000101426.5 ENSMUST00000101426.6 ENSMUST00000101426.7 ENSMUST00000101426.8 ENSMUST00000101426.9 Gs188 Keg2 NM_025326 Q3UCE2 Q8BV92 Q8K4T0 Q9DCS1 T176A_MOUSE uc009bvx.1 uc009bvx.2 uc009bvx.3 Interacts with MCOLN2. Membrane ; Multi-pass membrane protein Specifically expressed in lung, kidney and spleen. Up-regulated in kidney upon proteinuria. Belongs to the TMEM176 family. Sequence=BAE29671.1; Type=Frameshift; Evidence=; protein binding membrane integral component of membrane negative regulation of dendritic cell differentiation uc009bvx.1 uc009bvx.2 uc009bvx.3 
ENSMUST00000101432.3 Npas3 ENSMUST00000101432.3 neuronal PAS domain protein 3, transcript variant 1 (from RefSeq NM_013780.3) ENSMUST00000101432.1 ENSMUST00000101432.2 F8VQB2 F8VQB2_MOUSE NM_013780 Npas3 uc007nno.1 uc007nno.2 Nucleus nucleus nucleoplasm cytosol regulation of transcription, DNA-templated protein dimerization activity uc007nno.1 uc007nno.2 
ENSMUST00000101433.9 Smim9 ENSMUST00000101433.9 small integral membrane protein 9 (from RefSeq NM_001033786.2) ENSMUST00000101433.1 ENSMUST00000101433.2 ENSMUST00000101433.3 ENSMUST00000101433.4 ENSMUST00000101433.5 ENSMUST00000101433.6 ENSMUST00000101433.7 ENSMUST00000101433.8 NM_001033786 Q3V0X1 SMIM9_MOUSE uc009tps.1 uc009tps.2 uc009tps.3 Cell membrane ; Single-pass type I membrane protein molecular_function cellular_component plasma membrane biological_process membrane integral component of membrane uc009tps.1 uc009tps.2 uc009tps.3 
ENSMUST00000101445.11 Zfp956 ENSMUST00000101445.11 zinc finger protein 956 (from RefSeq NM_178898.4) AI894139 ENSMUST00000101445.1 ENSMUST00000101445.10 ENSMUST00000101445.2 ENSMUST00000101445.3 ENSMUST00000101445.4 ENSMUST00000101445.5 ENSMUST00000101445.6 ENSMUST00000101445.7 ENSMUST00000101445.8 ENSMUST00000101445.9 NM_178898 Q3UZY6 Q3UZY6_MOUSE Zfp956 uc009bts.1 uc009bts.2 uc009bts.3 uc009bts.4 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009bts.1 uc009bts.2 uc009bts.3 uc009bts.4 
ENSMUST00000101448.5 Drc1 ENSMUST00000101448.5 dynein regulatory complex subunit 1 (from RefSeq NM_001033460.4) B9EKF0 Ccdc164 DRC1_MOUSE ENSMUST00000101448.1 ENSMUST00000101448.2 ENSMUST00000101448.3 ENSMUST00000101448.4 Gm1060 NM_001033460 Q3USS3 uc057llr.1 uc057llr.2 uc057llr.3 Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N- DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes (PubMed:34169321). Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Component of the nexin-dynein regulatory complex (N-DRC). Interacts with CCDC65/DRC2, DRC3, GAS8/DRC4 and TCTE1/DRC5. Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme At 7.5 dpc, expressed in the pit cells of the node, which carry motile cilia and are involved in left-right axis development. Knockout mice on a C57BL/6 background experience pre-puberal death, usually before postnatal day 12, and exhibit signs of growth retardation and hydrocephaly. Mutant mice on C57BL/6 x ICR background can survive to adulthood, are infertile, and have reduced sperm counts with short or absent flagella. Belongs to the DRC1 family. regulation of cilium movement molecular_function cytoplasm cytosol cytoskeleton axonemal dynein complex cilium axoneme determination of left/right symmetry heart development motile cilium cell projection cilium-dependent cell motility axonemal dynein complex assembly uc057llr.1 uc057llr.2 uc057llr.3 
ENSMUST00000101450.3 Gm10466 ENSMUST00000101450.3 predicted gene 10466 (from RefSeq NR_033491.1) ENSMUST00000101450.1 ENSMUST00000101450.2 NR_033491 uc011xsh.1 uc011xsh.2 uc011xsh.1 uc011xsh.2 
ENSMUST00000101471.4 Dpp6 ENSMUST00000101471.4 dipeptidylpeptidase 6, transcript variant 1 (from RefSeq NM_001136060.2) Dpp6 ENSMUST00000101471.1 ENSMUST00000101471.2 ENSMUST00000101471.3 NM_001136060 Q80VM5 Q80VM5_MOUSE uc008wto.1 uc008wto.2 uc008wto.3 uc008wto.4 proteolysis serine-type peptidase activity membrane integral component of membrane uc008wto.1 uc008wto.2 uc008wto.3 uc008wto.4 
ENSMUST00000101486.5 Xlr3b ENSMUST00000101486.5 X-linked lymphocyte-regulated 3B, transcript variant 3 (from RefSeq NM_001405806.1) ENSMUST00000101486.1 ENSMUST00000101486.2 ENSMUST00000101486.3 ENSMUST00000101486.4 NM_001405806 Q6P205 XL3B_MOUSE Xlr3b uc009tlh.1 uc009tlh.2 uc009tlh.3 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle positive regulation of synapse assembly positive regulation of dendritic spine morphogenesis uc009tlh.1 uc009tlh.2 uc009tlh.3 
ENSMUST00000101492.10 Dennd11 ENSMUST00000101492.10 DENN domain containing 11 (from RefSeq NM_001356375.1) DEN11_MOUSE ENSMUST00000101492.1 ENSMUST00000101492.2 ENSMUST00000101492.3 ENSMUST00000101492.4 ENSMUST00000101492.5 ENSMUST00000101492.6 ENSMUST00000101492.7 ENSMUST00000101492.8 ENSMUST00000101492.9 Kiaa1147 Lchn NM_001356375 Q3UHG7 Q3UT59 Q80TI8 Q8C6M2 uc009bmo.1 uc009bmo.2 uc009bmo.3 Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UHG7-1; Sequence=Displayed; Name=2; IsoId=Q3UHG7-2; Sequence=VSP_030494; Belongs to the DENND11 family. molecular_function uc009bmo.1 uc009bmo.2 uc009bmo.3 
ENSMUST00000101499.10 Cbll1 ENSMUST00000101499.10 Casitas B-lineage lymphoma-like 1, transcript variant 1 (from RefSeq NM_001253847.1) Cbll1 ENSMUST00000101499.1 ENSMUST00000101499.2 ENSMUST00000101499.3 ENSMUST00000101499.4 ENSMUST00000101499.5 ENSMUST00000101499.6 ENSMUST00000101499.7 ENSMUST00000101499.8 ENSMUST00000101499.9 HAKAI_MOUSE Hakai NM_001253847 Q3TMC0 Q8C7W5 Q8VCL9 Q9JIY2 uc007nhm.1 uc007nhm.2 uc007nhm.3 uc007nhm.4 E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (PubMed:11836526, PubMed:22252131). Targets CDH1 for endocytosis and degradation (PubMed:11836526). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716). Its function in the WMM complex is unknown (PubMed:29535189, PubMed:29547716). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homodimer (PubMed:22252131). Interacts with tyrosine- phosphorylated SRC substrates (PubMed:11836526, PubMed:22252131). Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:29535189, PubMed:29547716). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:29535189, PubMed:29547716). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29535189, PubMed:29547716). Also a component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (By similarity). Q9JIY2; Q9JIY2: Cbll1; NbExp=7; IntAct=EBI-7644904, EBI-7644904; Q9JIY2; Q60598: Cttn; NbExp=4; IntAct=EBI-7644904, EBI-397955; Q9JIY2; P12830: CDH1; Xeno; NbExp=21; IntAct=EBI-7644904, EBI-727477; Q9JIY2; Q14247: CTTN; Xeno; NbExp=8; IntAct=EBI-7644904, EBI-351886; Q9JIY2; Q99704: DOK1; Xeno; NbExp=2; IntAct=EBI-7644904, EBI-1384360; Nucleus speckle Nucleus, nucleoplasm Cytoplasm Note=Mainly nuclear with some fraction located in the cytoplasm (PubMed:29547716). ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus (PubMed:29547716). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9JIY2-1; Sequence=Displayed; Name=2; IsoId=Q9JIY2-2; Sequence=VSP_024416; Name=3; IsoId=Q9JIY2-3; Sequence=VSP_024416, VSP_024418, VSP_024419; Name=4; IsoId=Q9JIY2-4; Sequence=VSP_024415, VSP_024417; Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids. Phosphorylated on tyrosine residues. Belongs to the Hakai family. Sequence=BAE38522.1; Type=Frameshift; Evidence=; protein binding nucleus nucleoplasm cytoplasm negative regulation of cell adhesion multicellular organism development protein ubiquitination nuclear speck transferase activity positive regulation of cell migration MIS complex identical protein binding positive regulation of endocytosis metal ion binding ubiquitin protein ligase activity mRNA methylation cell-cell adhesion uc007nhm.1 uc007nhm.2 uc007nhm.3 uc007nhm.4 
ENSMUST00000101509.9 Ids ENSMUST00000101509.9 iduronate 2-sulfatase, transcript variant 1 (from RefSeq NM_010498.4) ENSMUST00000101509.1 ENSMUST00000101509.2 ENSMUST00000101509.3 ENSMUST00000101509.4 ENSMUST00000101509.5 ENSMUST00000101509.6 ENSMUST00000101509.7 ENSMUST00000101509.8 IDS_MOUSE NM_010498 Q08890 Q32KI7 Q3TM30 uc012hjl.1 uc012hjl.2 uc012hjl.3 uc012hjl.4 Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. Reaction=Hydrolysis of the 2-sulfate groups of the L-iduronate 2- sulfate units of dermatan sulfate, heparan sulfate and heparin.; EC=3.1.6.13; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Monomer. The 58-kDa mature form is composed of two chains resulting from proteolitic processing, the 42-kDa chain and the 14-kDa chain that remain stably associated and form the 58-kDa intermediate form which is enzymatically active. Lysosome Found to be expressed in alpha and beta pancreatic cells. By glucose, in a dose dependent manner. Synthesized as a 75-kDa precursor form in the endoplasmic reticulum (ER), and then processed by proteolytic cleavage through various intermediates to yield a 55-kDa mature form, with the release of an 18 kDa polypeptide. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. Belongs to the sulfatase family. Sequence=AAA37880.1; Type=Frameshift; Evidence=; catalytic activity iduronate-2-sulfatase activity protein binding lysosome sulfuric ester hydrolase activity hydrolase activity metal ion binding uc012hjl.1 uc012hjl.2 uc012hjl.3 uc012hjl.4 
ENSMUST00000101525.9 Upp1 ENSMUST00000101525.9 uridine phosphorylase 1, transcript variant 3 (from RefSeq NM_001159401.1) ENSMUST00000101525.1 ENSMUST00000101525.2 ENSMUST00000101525.3 ENSMUST00000101525.4 ENSMUST00000101525.5 ENSMUST00000101525.6 ENSMUST00000101525.7 ENSMUST00000101525.8 NM_001159401 Q5SUC8 Q5SUC8_MOUSE Upp1 uc007hzx.1 uc007hzx.2 uc007hzx.3 uc007hzx.4 Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Reaction=phosphate + uridine = alpha-D-ribose 1-phosphate + uracil; Xref=Rhea:RHEA:24388, ChEBI:CHEBI:16704, ChEBI:CHEBI:17568, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.3; Evidence=; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1. Belongs to the PNP/UDP phosphorylase family. catalytic activity uridine phosphorylase activity nucleus nucleoplasm cytoplasm nucleoside metabolic process nucleotide catabolic process transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups cellular response to glucose starvation UMP salvage uc007hzx.1 uc007hzx.2 uc007hzx.3 uc007hzx.4 
ENSMUST00000101532.10 Dgki ENSMUST00000101532.10 diacylglycerol kinase, iota, transcript variant 1 (from RefSeq NM_001081206.2) D3YWQ0 D3Z2W1 DGKI_MOUSE Dgki ENSMUST00000101532.1 ENSMUST00000101532.2 ENSMUST00000101532.3 ENSMUST00000101532.4 ENSMUST00000101532.5 ENSMUST00000101532.6 ENSMUST00000101532.7 ENSMUST00000101532.8 ENSMUST00000101532.9 NM_001081206 uc009bjb.1 uc009bjb.2 uc009bjb.3 Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (By similarity). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway (PubMed:15894621). May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (PubMed:21119615). Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10273; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40324; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40339, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77097, ChEBI:CHEBI:77098, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40340; Evidence=; Lipid metabolism; glycerolipid metabolism. Interacts (via PDZ-binding motif) with DLG4; controls the localization of DGKI to the synapse (By similarity). Interacts (via PDZ-binding motif) with DLG1 (By similarity). Interacts (via PDZ- binding motif) with DLG2 (By similarity). Interacts (via PDZ-binding motif) with DLG3 (PubMed:21119615). May interact with RASGRP3; involved in the regulation of RASGRP3 activity (Probable). Cell projection, axon Cell projection, dendrite Presynapse Postsynapse Postsynaptic density Synaptic cell membrane Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Cytoplasm, cytosol Nucleus Note=Excluded from inhibitory synapses (By similarity). Localization between cytoplasm and nucleus is regulated by protein kinase C (By similarity). Both in the detergent soluble and particulate fractions (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=D3YWQ0-1; Sequence=Displayed; Name=2; IsoId=D3YWQ0-2; Sequence=VSP_060832; In brain, expressed in the hippocampus and cerebellum with stronger expression in the Purkinje cell layer (at protein level) (PubMed:21119615). Expressed in kidney (PubMed:15894621). Homozygous knockout mice lacking Dgki do not display overt phenotype (PubMed:15894621). They are slower to habituation to a novel environment, but have normal levels of locomotor activity, anxiety, and motor coordination (PubMed:21119615). They display a small increase in presynaptic release probability and synapses show a reduction in metabotropic glutamate receptor-dependent long-term depression (PubMed:21119615). Belongs to the eukaryotic diacylglycerol kinase family. nucleotide binding NAD+ kinase activity diacylglycerol kinase activity GTPase inhibitor activity ATP binding nucleus nucleoplasm cytoplasm cytosol signal transduction protein kinase C-activating G-protein coupled receptor signaling pathway neurotransmitter secretion synaptic vesicle postsynaptic density kinase activity phosphorylation transferase activity Ras GTPase binding guanyl-nucleotide exchange factor complex macromolecular complex negative regulation of GTPase activity intracellular signal transduction neuronal cell body regulation of GTPase activity dendritic spine axon terminus synapse diacylglycerol metabolic process glycerolipid metabolic process positive regulation of Ras protein signal transduction lipid phosphorylation habituation perinuclear region of cytoplasm presynaptic active zone regulation of synaptic transmission, glutamatergic excitatory synapse excitatory postsynaptic potential synaptic membrane extrinsic component of presynaptic active zone membrane glutamatergic synapse regulation of long term synaptic depression regulation of synaptic vesicle exocytosis uc009bjb.1 uc009bjb.2 uc009bjb.3 
ENSMUST00000101534.5 Ptn ENSMUST00000101534.5 pleiotrophin, transcript variant 1 (from RefSeq NM_008973.3) ENSMUST00000101534.1 ENSMUST00000101534.2 ENSMUST00000101534.3 ENSMUST00000101534.4 NM_008973 P20935 P63089 PTN_MOUSE Ptn uc009bja.1 uc009bja.2 uc009bja.3 Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:15121180, PubMed:30497772, PubMed:27445335, PubMed:19442624). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (PubMed:11414790, PubMed:25000129). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK or AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:27445335). Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:27445335). Forms a complex with PTPRZ1 and integrin alpha- V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (PubMed:30497772). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion (By similarity). Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway (PubMed:15121180). Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration (PubMed:21791434). In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (PubMed:17121547, PubMed:28657144, PubMed:16619002). Interacts with ALK and NEK6. Interacts with PTPRZ1 (via chondroitin sulfate groups); promotes formation of homooligomers; oligomerization impairs tyrosine phosphatase activity. Forms a complex with PTPRZ1 and CTNNB1; this complex inactivates PTPRZ1 protein tyrosine phosphatase activity through PTN interaction and stimulates tyrosine phosphorylation of CTNNB1. Interacts with ITGB3 and ITGA5. Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through ITGB3 'Tyr-773' phosphorylation (By similarity). Interacts with SDC3 (via heparan sulfate chains); this interaction mediates the neurite outgrowth- promoting signal from PTN to the cytoskeleton of growing neurites; this interaction mediates osteoblast recruitment. Interacts with GPC2 (via heparan sulfate); this interaction promotes neurite outgrowth through binding of PTN with chondroitin sulfate of proteoglycans, thereby releasing PTPRS of chondroitin sulfate proteoglycans (CSPGs) and leading to binding with heparan sulfate of GPC2 (By similarity). Secreted Osteoblast and brain (PubMed:1701634, PubMed:1768439). Expressed in the follicular epithelium and granulosa cells of the ovary. Strongly expressed in the uterus of newborn mice, and the degree of expression decreased in one-week-old mice, although the expression continues even in the uteri of adult mice. Expression gradually increases from proestrus to estrus, then decreases sharply, and thereafter gradually increased again (PubMed:17121547). strongly expressed in the cochlea of WT mice 1 week after birth, and then the expression decreased and was undetectable by week 8 after birth (PubMed:16619002). Expressed around the cell soma of osteocytes and apparently captured in the unmineralized interstitial matrix surrounding the cells. Furthermore distributed throughout the intraosseous canalicular porosity, being localized in the unmineralized matrix around the cell processes. Strongly expressed in the innermost layer of the periosteum (PubMed:19442624). NoT detected in the uteri from days 1-3 of pregnancy. On day 4 of pregnancy, localizes in the luminal and glandular epithelium as well as in the uterine stromal cells. On day 5, a high level is observed in the subluminal stroma surrounding the implanting blastocyst, while there is no expression at the inter- implantation sites. From day 6-8 of pregnancy, strongly expressed in the decidua. Expression is gradually increased as the progression of pregnancy and reached a maximum on day 8. Elevated expression is observed at implantation sites from days 5-8 of pregnancy. Enhanced up to 3 days after the administration of chorionic gonadotropin to induce ovulation (PubMed:17121547). Up-regulated by progesterone in the uterine stromal cells through cAMP (PubMed:28657144). Phosphorylated by NEK6. Homozygous PTN knockout mice are viable and fertile and show no gross anatomical abnormalities. The hippocampal structure as well as basal excitatory synaptic transmission in the area CA1 appear normal. The skeletal structure of homozygous PTN knockout mice develops normally. However, a growth retardation of the weight- bearing bones is observed by 2 months of age. Adult homozygous PTN knockout mice are characterized by low bone formation and osteopenia, as well as resistance to immobilization-dependent bone remodeling (PubMed:11414790, PubMed:12093164). Mice show faster learning in water maze and decreased anxiety in elevated plus-maze test (PubMed:12093164). Homozygous PTN knockout mice exhibit cognitive rigidity, heightened anxiety, behavioral reticence in novel contexts and novel social interactions. Initial learning of spatial and other associative tasks, as well as vascular density in the lateral entorhinal cortex, are normal (PubMed:25000129). PTN and MDK double knockout mice are born in only one third the number expected by Mendelian segregation and 4 weeks after birth weigh about half as much as wild-type mice. Most of the female are infertile. Both male and female one-month-old mice show a defect in spontaneous locomotive activity of 50-60% of that of wild-type mice. Although the difference in activity decrease with age, the activity of 3-month-old male double knockout mice is still about 80% of that of the wild-type mice. The diestrus and proestrus periods are long and the estrus period is short. Furthermore, vaginal abnormality is found in about half of the double deficient mice (PubMed:17121547). PTN and MDK double knockout mice have a deficit of auditory response (PubMed:16619002). Belongs to the pleiotrophin family. ossification liver development leukocyte chemotaxis involved in inflammatory response positive regulation of leukocyte chemotaxis protein phosphatase inhibitor activity integrin binding glycosaminoglycan binding extracellular region basement membrane extracellular space cytoplasm endoplasmic reticulum plasma membrane integrin-mediated signaling pathway negative regulation of neuroblast proliferation brain development heart development learning memory growth factor activity heparin binding positive regulation of cell proliferation regulation of cell shape cell surface regulation of endothelial cell migration positive regulation of cell-substrate adhesion positive regulation of neuron projection development response to auditory stimulus response to activity membrane negative regulation of angiogenesis protein kinase binding spinal cord development cerebellum development thalamus development bone mineralization lung development negative regulation of cell migration positive regulation of bone mineralization hindbrain development extracellular matrix dendrite regeneration neuromuscular junction regulation of myelination response to estradiol negative regulation of phosphoprotein phosphatase activity response to progesterone macromolecular complex cellular response to UV chondroitin sulfate proteoglycan binding chondroitin sulfate binding cellular response to platelet-derived growth factor stimulus vascular endothelial growth factor binding tissue regeneration response to drug positive regulation of apoptotic process receptor clustering proteoglycan binding ossification involved in bone remodeling estrous cycle endothelial cell differentiation syndecan binding positive regulation of cell differentiation positive regulation of ossification negative regulation of membrane potential decidualization regulation of synaptic plasticity perinuclear region of cytoplasm oogenesis positive regulation of axon regeneration positive regulation of oligodendrocyte differentiation negative regulation of epithelial cell proliferation positive regulation of cell division retina development in camera-type eye retinal rod cell differentiation negative regulation of glial cell proliferation long-term synaptic potentiation cellular response to vitamin D cellular response to organic cyclic compound cellular response to hypoxia negative regulation of mesenchymal cell proliferation presynapse postsynapse positive regulation of dendrite development negative regulation of long-term synaptic potentiation regulation of hemopoiesis response to kainic acid rod bipolar cell differentiation response to ciliary neurotrophic factor positive regulation of skeletal muscle acetylcholine-gated channel clustering negative regulation of neuromuscular junction development heparan sulfate binding response to nerve growth factor regulation of stem cell population maintenance positive regulation of hepatocyte proliferation positive regulation of stem cell differentiation uc009bja.1 uc009bja.2 uc009bja.3 
ENSMUST00000101535.9 9330158H04Rik ENSMUST00000101535.9 9330158H04Rik (from geneSymbol) AK139997 ENSMUST00000101535.1 ENSMUST00000101535.2 ENSMUST00000101535.3 ENSMUST00000101535.4 ENSMUST00000101535.5 ENSMUST00000101535.6 ENSMUST00000101535.7 ENSMUST00000101535.8 uc009biu.1 uc009biu.2 uc009biu.3 uc009biu.1 uc009biu.2 uc009biu.3 
ENSMUST00000101538.5 9030624G23Rik ENSMUST00000101538.5 RIKEN cDNA 9030624G23 gene, transcript variant 2 (from RefSeq NM_001256489.2) 9030624G23Rik ENSMUST00000101538.1 ENSMUST00000101538.2 ENSMUST00000101538.3 ENSMUST00000101538.4 NM_001256489 Q9D308 Q9D308_MOUSE uc007neh.1 uc007neh.2 uc007neh.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process uc007neh.1 uc007neh.2 uc007neh.3 
ENSMUST00000101547.12 Zfp934 ENSMUST00000101547.12 zinc finger protein 934, transcript variant 1 (from RefSeq NM_001162911.2) ENSMUST00000101547.1 ENSMUST00000101547.10 ENSMUST00000101547.11 ENSMUST00000101547.2 ENSMUST00000101547.3 ENSMUST00000101547.4 ENSMUST00000101547.5 ENSMUST00000101547.6 ENSMUST00000101547.7 ENSMUST00000101547.8 ENSMUST00000101547.9 K7N6H3 K7N6H3_MOUSE NM_001162911 Zfp934 uc007qwz.1 uc007qwz.2 uc007qwz.3 uc007qwz.4 Nucleus nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007qwz.1 uc007qwz.2 uc007qwz.3 uc007qwz.4 
ENSMUST00000101560.4 Zfp449 ENSMUST00000101560.4 zinc finger protein 449, transcript variant 1 (from RefSeq NM_030139.5) ENSMUST00000101560.1 ENSMUST00000101560.2 ENSMUST00000101560.3 NM_030139 Q8CB76 Q8CB76_MOUSE Zfp449 uc009tgb.1 uc009tgb.2 uc009tgb.3 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated spermatogonial cell division metal ion binding uc009tgb.1 uc009tgb.2 uc009tgb.3 
ENSMUST00000101561.8 Gm773 ENSMUST00000101561.8 predicted gene 773 (from RefSeq NM_001033423.2) ENSMUST00000101561.1 ENSMUST00000101561.2 ENSMUST00000101561.3 ENSMUST00000101561.4 ENSMUST00000101561.5 ENSMUST00000101561.6 ENSMUST00000101561.7 Gm773 NM_001033423 Q3TML4 Q3TML4_MOUSE uc009tfz.1 uc009tfz.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc009tfz.1 uc009tfz.2 
ENSMUST00000101562.11 Asap2 ENSMUST00000101562.11 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2, transcript variant 1 (from RefSeq NM_001098168.1) ASAP2_MOUSE Ddef2 ENSMUST00000101562.1 ENSMUST00000101562.10 ENSMUST00000101562.2 ENSMUST00000101562.3 ENSMUST00000101562.4 ENSMUST00000101562.5 ENSMUST00000101562.6 ENSMUST00000101562.7 ENSMUST00000101562.8 ENSMUST00000101562.9 Gm1523 Gm592 NM_001098168 Q501K1 Q66JN2 Q7SIG6 uc007ndi.1 uc007ndi.2 uc007ndi.3 Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration (By similarity). Binds PXN, ARF1, ARF5, ARF6, PTK2B and SRC. Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Note=Colocalizes with F-actin and ARF6 in phagocytic cups. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7SIG6-1; Sequence=Displayed; Name=2; IsoId=Q7SIG6-2; Sequence=VSP_014776, VSP_014777; The conserved Arg-467 in the Arf-GAP domain probably becomes part of the active site of bound small GTPases and is necessary for GTP hydrolysis. Phosphorylated on tyrosine residues by SRC and PTK2B. GTPase activator activity cellular_component cytoplasm Golgi apparatus plasma membrane membrane Golgi cisterna membrane positive regulation of GTPase activity metal ion binding uc007ndi.1 uc007ndi.2 uc007ndi.3 
ENSMUST00000101588.2 Ccdc160 ENSMUST00000101588.2 coiled-coil domain containing 160 (from RefSeq NM_001034059.2) CC160_MOUSE ENSMUST00000101588.1 NM_001034059 Q3UYG1 uc009tem.1 uc009tem.2 Belongs to the CCDC160 family. molecular_function cellular_component biological_process uc009tem.1 uc009tem.2 
ENSMUST00000101589.5 Klf14 ENSMUST00000101589.5 Kruppel-like transcription factor 14 (from RefSeq NM_001135093.1) ENSMUST00000101589.1 ENSMUST00000101589.2 ENSMUST00000101589.3 ENSMUST00000101589.4 KLF14_MOUSE NM_001135093 Q19A41 uc012ejp.1 uc012ejp.2 uc012ejp.3 Nucleus Belongs to the Sp1 C2H2-type zinc-finger protein family. RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleic acid binding DNA binding chromatin binding nucleus regulation of transcription from RNA polymerase II promoter transcription factor binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of sphingolipid mediated signaling pathway uc012ejp.1 uc012ejp.2 uc012ejp.3 
ENSMUST00000101610.10 Rhbdd3 ENSMUST00000101610.10 rhomboid domain containing 3, transcript variant 5 (from RefSeq NR_110961.1) A2RTD2 B7ZNK0 ENSMUST00000101610.1 ENSMUST00000101610.2 ENSMUST00000101610.3 ENSMUST00000101610.4 ENSMUST00000101610.5 ENSMUST00000101610.6 ENSMUST00000101610.7 ENSMUST00000101610.8 ENSMUST00000101610.9 NR_110961 Q3U0Y4 Q5SUT5 Q5SUT6 Q5SUT7 Q8BP97 RHBD3_MOUSE uc007hwb.1 uc007hwb.2 uc007hwb.3 uc007hwb.4 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BP97-1; Sequence=Displayed; Name=2; IsoId=Q8BP97-2; Sequence=VSP_014669; MAPK cascade liver development regulation of acute inflammatory response serine-type endopeptidase activity protein binding proteolysis response to xenobiotic stimulus membrane integral component of membrane negative regulation of natural killer cell activation positive regulation of protein catabolic process regulation of protein secretion uc007hwb.1 uc007hwb.2 uc007hwb.3 uc007hwb.4 
ENSMUST00000101614.10 Kcp ENSMUST00000101614.10 kielin/chordin-like protein (from RefSeq NM_001029985.4) Crim2 E9QJU0 ENSMUST00000101614.1 ENSMUST00000101614.2 ENSMUST00000101614.3 ENSMUST00000101614.4 ENSMUST00000101614.5 ENSMUST00000101614.6 ENSMUST00000101614.7 ENSMUST00000101614.8 ENSMUST00000101614.9 KCP_MOUSE Kcp1 NM_001029985 Q3U492 Q56NI8 uc009bdt.1 uc009bdt.2 uc009bdt.3 uc009bdt.4 Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways. Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine-/threonine protein kinase domains. Also able to interact with activin-A and TGFB1. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U492-1; Sequence=Displayed; Name=2; IsoId=Q3U492-2; Sequence=VSP_031232, VSP_031233; Weakly expressed in embryonic kidney and brain. Not expressed in adult tissues and several cell lines. Prominently expressed in two areas, the limb buds and the developing kidney, with diffuse staining in the central nervous system. At 9.5 dpc the limb bud mesenchyme is positive. Expression in the kidney region could be detected as early as 9 dpc in the intermediate mesoderm. By 10 dpc, the mesonephric tubules and nephric ducts are clearly positive. At later stages, high levels are localized to the developing tubules. At 18.5 dpc, it is localized to more mature renal tubules located in the developing cortex with little expression detected in the nephrogenic zone. By renal stresses. hematopoietic progenitor cell differentiation protein binding extracellular region extracellular space positive regulation of BMP signaling pathway uc009bdt.1 uc009bdt.2 uc009bdt.3 uc009bdt.4 
ENSMUST00000101616.9 Smarca1 ENSMUST00000101616.9 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1, transcript variant 3 (from RefSeq NM_001358618.1) B1AUP6 B1AUP7 ENSMUST00000101616.1 ENSMUST00000101616.2 ENSMUST00000101616.3 ENSMUST00000101616.4 ENSMUST00000101616.5 ENSMUST00000101616.6 ENSMUST00000101616.7 ENSMUST00000101616.8 NM_001358618 Q6PGB8 Q8BSS1 Q91Y58 SMCA1_MOUSE Snf2l uc009tbm.1 uc009tbm.2 uc009tbm.3 uc009tbm.4 Helicase that possesses intrinsic ATP-dependent chromatin- remodeling activity (By similarity). ATPase activity is substrate- dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (By similarity). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (By similarity). Within the ISWI chromatin- remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (By similarity). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin- remodeling complexes (By similarity). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (By similarity). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (By similarity). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (By similarity). Within the NURF-1 ISWI chromatin- remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (By similarity). May promote neurite outgrowth (By similarity). May be involved in the development of luteal cells (By similarity). May form homodimers (By similarity). Component of the ACF-1 ISWI chromatin remodeling complex at least composed of SMARCA1 and BAZ1A, which regulates the spacing of histone octamers on the DNA template to facilitate access to DNA (By similarity). Within the complex interacts with BAZ1A; the interaction is direct (By similarity). Component of the WICH-1 ISWI chromatin remodeling complex at least composed of SMARCA1 and BAZ1B/WSTF (By similarity). Within the complex interacts with BAZ1B/WSTF (By similarity). Component of the NoRC-1 ISWI chromatin remodeling complex at least composed of SMARCA1 and BAZ2A/TIP5 (By similarity). Within the complex interacts with BAZ2A/TIP5 (By similarity). Component of the BRF-1 ISWI chromatin remodeling complex at least composed of SMARCA1 and BAZ2B (By similarity). Within the complex interacts with BAZ2B (By similarity). Component of the NURF-1 ISWI chromatin remodeling complex (also called the nucleosome-remodeling factor (NURF) complex) at least composed of SMARCA1, BPTF, RBBP4 and RBBP7 (By similarity). Within the complex interacts with BPTF (By similarity). Within the complex interacts with RBBP4 and RBBP7 (By similarity). Component of the CERF-1 ISWI chromatin remodeling complex (also called the CECR2-containing-remodeling factor (CERF) complex) at least composed of CECR2 and SMARCA1 (By similarity). Within the complex interacts with CECR2 (By similarity). Component of the RSF-1 ISWI chromatin remodeling complex at least composed of SMARCA1 and RSF1 (By similarity). Within the complex interacts with RSF1 (By similarity). Interacts with PRLR (By similarity). Interacts with ERCC6 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PGB8-1; Sequence=Displayed; Name=2; IsoId=Q6PGB8-2; Sequence=VSP_020378; Predominantly expressed in cortex, cerebellum, ovaries, testes, uterus and placenta. Expressed throughout the embryo at 9.5 dpc-15.5 dpc. Brain expression increases during the first two weeks of postnatal development. By ovulation in ovaries (at protein level). Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. Sequence=AAK52453.1; Type=Frameshift; Evidence=; nucleotide binding DNA strand renaturation nuclear chromatin nucleic acid binding DNA binding helicase activity ATP binding nucleus nucleoplasm chromatin organization chromatin remodeling regulation of transcription, DNA-templated brain development DNA-dependent ATPase activity transcription factor binding nucleosome positioning NURF complex hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ATPase activity neuron differentiation nucleosome binding annealing helicase activity ATP-dependent chromatin remodeling intracellular membrane-bounded organelle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter nucleosome-dependent ATPase activity CERF complex regulation of neural precursor cell proliferation uc009tbm.1 uc009tbm.2 uc009tbm.3 uc009tbm.4 
ENSMUST00000101627.5 Fam237b ENSMUST00000101627.5 family with sequence similarity 237, member B (from RefSeq NM_001384231.1) EG667705 ENSMUST00000101627.1 ENSMUST00000101627.2 ENSMUST00000101627.3 ENSMUST00000101627.4 Fam237b Gm8773 NM_001384231 Q3UQ24 Q3UQ24_MOUSE uc008wit.1 uc008wit.2 uc008wit.3 uc008wit.1 uc008wit.2 uc008wit.3 
ENSMUST00000101636.3 Gm9 ENSMUST00000101636.3 predicted gene 9 (from RefSeq NM_001033234.2) ENSMUST00000101636.1 ENSMUST00000101636.2 Gm9 NM_001033234 Q3UKW5 Q3UKW5_MOUSE uc009syk.1 uc009syk.2 uc009syk.3 molecular_function cellular_component biological_process uc009syk.1 uc009syk.2 uc009syk.3 
ENSMUST00000101638.4 Limk2 ENSMUST00000101638.4 LIM domain kinase 2, transcript variant 1 (from RefSeq NM_010718.4) ENSMUST00000101638.1 ENSMUST00000101638.2 ENSMUST00000101638.3 LIMK2_MOUSE NM_010718 O54776 O54785 O55238 Q9QUL4 uc007hsu.1 uc007hsu.2 uc007hsu.3 uc007hsu.4 Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Binds ROCK1 and MARF1 (By similarity). Interacts with NISCH (PubMed:18332102). Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome [Isoform LIMK2a]: Cytoplasm Nucleus [Isoform LIMK2b]: Cytoplasm Cytoplasm, perinuclear region Nucleus Event=Alternative splicing; Named isoforms=3; Name=LIMK2a; IsoId=O54785-1; Sequence=Displayed; Name=LIMK2b; IsoId=O54785-2; Sequence=VSP_010350; Name=3; Synonyms=LIMK2t, tLIMK2; IsoId=O54785-3; Sequence=VSP_010351; [Isoform 3]: Specifically expressed in the testes. Phosphorylated on serine and/or threonine residues by ROCK1. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm cis-Golgi network protein phosphorylation spermatogenesis kinase activity phosphorylation transferase activity actin cytoskeleton organization metal ion binding protein heterodimerization activity head development cornea development in camera-type eye uc007hsu.1 uc007hsu.2 uc007hsu.3 uc007hsu.4 
ENSMUST00000101645.10 Gm14819 ENSMUST00000101645.10 predicted gene 14819 (from RefSeq NM_001110250.2) ENSMUST00000101645.1 ENSMUST00000101645.2 ENSMUST00000101645.3 ENSMUST00000101645.4 ENSMUST00000101645.5 ENSMUST00000101645.6 ENSMUST00000101645.7 ENSMUST00000101645.8 ENSMUST00000101645.9 Gm10058 Gm10096 Gm10147 Gm10230 Gm10486 Gm10487 Gm14632 Gm14819 Gm4836 NM_001110250 Q62478 Q62478_MOUSE XMR uc009sxg.1 uc009sxg.2 uc009sxg.3 uc009sxg.4 uc009sxg.5 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function nucleus spermatogenesis spermatid development meiotic cell cycle uc009sxg.1 uc009sxg.2 uc009sxg.3 uc009sxg.4 uc009sxg.5 
ENSMUST00000101647.4 Gm10486 ENSMUST00000101647.4 predicted gene 10486 (from RefSeq NM_001109970.1) ENSMUST00000101647.1 ENSMUST00000101647.2 ENSMUST00000101647.3 Gm10058 Gm10096 Gm10147 Gm10230 Gm10486 Gm10487 Gm14632 Gm14819 Gm4836 NM_001109970 Q62478 Q62478_MOUSE XMR uc009sxc.1 uc009sxc.2 uc009sxc.3 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function nucleus spermatogenesis spermatid development meiotic cell cycle uc009sxc.1 uc009sxc.2 uc009sxc.3 
ENSMUST00000101654.10 Gm14632 ENSMUST00000101654.10 predicted gene 14632 (from RefSeq NM_001100610.2) ENSMUST00000101654.1 ENSMUST00000101654.2 ENSMUST00000101654.3 ENSMUST00000101654.4 ENSMUST00000101654.5 ENSMUST00000101654.6 ENSMUST00000101654.7 ENSMUST00000101654.8 ENSMUST00000101654.9 Gm10058 Gm10096 Gm10147 Gm10230 Gm10486 Gm10487 Gm14632 Gm14819 Gm4836 NM_001100610 Q62478 Q62478_MOUSE XMR uc009swn.1 uc009swn.2 uc009swn.3 uc009swn.4 uc009swn.5 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function nucleus spermatogenesis spermatid development meiotic cell cycle uc009swn.1 uc009swn.2 uc009swn.3 uc009swn.4 uc009swn.5 
ENSMUST00000101657.4 Gm10488 ENSMUST00000101657.4 predicted gene 10488 (from RefSeq NM_001099325.2) ENSMUST00000101657.1 ENSMUST00000101657.2 ENSMUST00000101657.3 Gm10488 NM_001099325 Q4KL05 Q4KL05_MOUSE Slx Xmr uc009swk.1 uc009swk.2 uc009swk.3 uc009swk.4 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc009swk.1 uc009swk.2 uc009swk.3 uc009swk.4 
ENSMUST00000101667.10 Gm5935 ENSMUST00000101667.10 predicted gene 5935 (from RefSeq NM_001081657.1) EG546282 ENSMUST00000101667.1 ENSMUST00000101667.2 ENSMUST00000101667.3 ENSMUST00000101667.4 ENSMUST00000101667.5 ENSMUST00000101667.6 ENSMUST00000101667.7 ENSMUST00000101667.8 ENSMUST00000101667.9 Gm5935 NM_001081657 Q497S0 Q497S0_MOUSE uc009svc.1 uc009svc.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc009svc.1 uc009svc.2 
ENSMUST00000101698.4 Ezhip ENSMUST00000101698.4 EZH inhibitory protein, transcript variant 2 (from RefSeq NM_001033211.3) AU022751 B1B0V2 ENSMUST00000101698.1 ENSMUST00000101698.2 ENSMUST00000101698.3 EZHIP_MOUSE Ezhip KIP75 NM_001033211 Q3TL73 Q3UWZ4 Q497U5 uc009skv.1 uc009skv.2 uc009skv.3 uc009skv.4 Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down- regulation of histone H3 trimethylation at 'Lys-27' (H3K27me3) (PubMed:31086175). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (By similarity). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (PubMed:31451685). Interacts with PRC2/EED-EZH1 complex member EZH1 and with PRC2/EED-EZH2 complex member EZH2; the interaction blocks EZH1/EZH2 methyltransferase activity (PubMed:31086175). Interacts (via C- terminus) with SUZ12 which is a member of the PRC2/EED-EZH1 and PRC2/EED-EZH2 complexes (By similarity). Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B1B0V2-1; Sequence=Displayed; Name=2; IsoId=B1B0V2-2; Sequence=VSP_060652; Highly expressed in ovary with lower expression in testis and very low levels in other tissues tested including prostate, brain, kidney, spleen and liver (PubMed:31451685). During spermatogenesis, expressed mainly in spermatogonia with very low expression in spermatocytes I and II (PubMed:31451685). No overt developmental defects with mutant adults appearing indistinguishable from wild-type (PubMed:31451685). Two-fold increase in H3K27me2 and H3K27me3 levels in germ cells in testis but males display normal testis-to-body weight ratio and normal fertility (PubMed:31451685). Increased H3K27me3 levels in postnatal oocytes and slight increase in the number of oocytes with lagging chromosomes (PubMed:31451685). No significant differences in the number of primordial, primary and secondary/antral follicles of pre-pubertal females but older females show a reduced number of follicles at 16 weeks (PubMed:31451685). Females have smaller ovaries and give rise to fewer progeny as they age (PubMed:31451685). molecular_function cellular_component biological_process uc009skv.1 uc009skv.2 uc009skv.3 uc009skv.4 
ENSMUST00000101801.8 Selenos ENSMUST00000101801.8 selenoprotein S, transcript variant 1 (from RefSeq NM_024439.3) ENSMUST00000101801.1 ENSMUST00000101801.2 ENSMUST00000101801.3 ENSMUST00000101801.4 ENSMUST00000101801.5 ENSMUST00000101801.6 ENSMUST00000101801.7 H47 NM_024439 Q921S1 Q9BCZ4 Q9DB55 SELS_MOUSE Selenos Vimp uc009hha.1 uc009hha.2 This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017]. Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity). Interacts with DERL1 and (via VIM motif) with VCP, suggesting that it forms a membrane complex with DERL1 that serves as a receptor for VCP. Also interacts with DERL2, DERL3 and SELENOK. The SELENOK- SELENOS complex interacts with VCP (By similarity). Interacts with CCDC47 (PubMed:25009997). Endoplasmic reticulum membrane ; Single-pass membrane protein Cytoplasm Truncated SELENOS proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC2) and CRL2(KLHDC3) complexes, which recognizes the glycine (Gly) at the C-terminus of truncated SELENOS proteins. Truncated SELENOS proteins produced by failed UGA/Sec decoding are also ubiquitinated by the CRL5(KLHDC1) complex. One of the histocompatibility antigen responsible for chronic graft rejection. Belongs to the selenoprotein S family. Sequence=AAH11091.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=AAK07659.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAB23882.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; negative regulation of acute inflammatory response to antigenic stimulus protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytoplasmic microtubule intracellular protein transport ER overload response response to glucose membrane integral component of membrane antioxidant activity enzyme binding integral component of endoplasmic reticulum membrane ER-associated ubiquitin-dependent protein catabolic process endoplasmic reticulum unfolded protein response retrograde protein transport, ER to cytosol negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production very-low-density lipoprotein particle low-density lipoprotein particle cellular response to oxidative stress Derlin-1-VIMP complex Derlin-1 retrotranslocation complex cell redox homeostasis negative regulation of inflammatory response ATPase binding negative regulation of nitric-oxide synthase biosynthetic process response to redox state cellular response to lipopolysaccharide regulation of nitric oxide metabolic process cellular oxidant detoxification negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ubiquitin-specific protease binding negative regulation of macrophage apoptotic process uc009hha.1 uc009hha.2 
ENSMUST00000101803.3 Gm22834 ENSMUST00000101803.3 Gm22834 (from geneSymbol) ENSMUST00000101803.1 ENSMUST00000101803.2 uc291qpk.1 uc291qpk.2 uc291qpk.1 uc291qpk.2 
ENSMUST00000101806.4 Gm23472 ENSMUST00000101806.4 Gm23472 (from geneSymbol) DQ551040 ENSMUST00000101806.1 ENSMUST00000101806.2 ENSMUST00000101806.3 uc287jbd.1 uc287jbd.2 uc287jbd.1 uc287jbd.2 
ENSMUST00000101817.3 Rnu5g ENSMUST00000101817.3 RNA, U5G small nuclear (from RefSeq NR_002852.3) ENSMUST00000101817.1 ENSMUST00000101817.2 NR_002852 uc292iel.1 uc292iel.2 uc292iel.1 uc292iel.2 
ENSMUST00000101821.3 Gm24517 ENSMUST00000101821.3 Gm24517 (from geneSymbol) DQ558729 ENSMUST00000101821.1 ENSMUST00000101821.2 uc287jdi.1 uc287jdi.2 uc287jdi.1 uc287jdi.2 
ENSMUST00000101824.3 Gm22589 ENSMUST00000101824.3 Gm22589 (from geneSymbol) ENSMUST00000101824.1 ENSMUST00000101824.2 uc289kmu.1 uc289kmu.2 uc289kmu.1 uc289kmu.2 
ENSMUST00000101829.4 Gm26375 ENSMUST00000101829.4 Gm26375 (from geneSymbol) ENSMUST00000101829.1 ENSMUST00000101829.2 ENSMUST00000101829.3 uc289hdb.1 uc289hdb.2 uc289hdb.1 uc289hdb.2 
ENSMUST00000101832.3 Gm25823 ENSMUST00000101832.3 Gm25823 (from geneSymbol) ENSMUST00000101832.1 ENSMUST00000101832.2 uc291qqr.1 uc291qqr.2 uc291qqr.1 uc291qqr.2 
ENSMUST00000101833.4 Gm25284 ENSMUST00000101833.4 Gm25284 (from geneSymbol) ENSMUST00000101833.1 ENSMUST00000101833.2 ENSMUST00000101833.3 uc290yuj.1 uc290yuj.2 uc290yuj.1 uc290yuj.2 
ENSMUST00000101848.4 Gm23142 ENSMUST00000101848.4 Gm23142 (from geneSymbol) ENSMUST00000101848.1 ENSMUST00000101848.2 ENSMUST00000101848.3 uc291ypn.1 uc291ypn.2 uc291ypn.1 uc291ypn.2 
ENSMUST00000101867.4 Gm26500 ENSMUST00000101867.4 Gm26500 (from geneSymbol) ENSMUST00000101867.1 ENSMUST00000101867.2 ENSMUST00000101867.3 uc289hcm.1 uc289hcm.2 uc289hcm.1 uc289hcm.2 
ENSMUST00000101878.3 Gm23691 ENSMUST00000101878.3 Gm23691 (from geneSymbol) ENSMUST00000101878.1 ENSMUST00000101878.2 uc289srv.1 uc289srv.2 uc289srv.1 uc289srv.2 
ENSMUST00000101881.4 Gm23692 ENSMUST00000101881.4 Gm23692 (from geneSymbol) ENSMUST00000101881.1 ENSMUST00000101881.2 ENSMUST00000101881.3 uc289gjk.1 uc289gjk.2 uc289gjk.1 uc289gjk.2 
ENSMUST00000101884.3 Gm22004 ENSMUST00000101884.3 Gm22004 (from geneSymbol) ENSMUST00000101884.1 ENSMUST00000101884.2 uc288iay.1 uc288iay.2 uc288iay.1 uc288iay.2 
ENSMUST00000101891.4 Snord116l9 ENSMUST00000101891.4 Snord116l9 (from geneSymbol) ENSMUST00000101891.1 ENSMUST00000101891.2 ENSMUST00000101891.3 uc291qvl.1 uc291qvl.2 uc291qvl.1 uc291qvl.2 
ENSMUST00000101893.4 Gm26240 ENSMUST00000101893.4 Gm26240 (from geneSymbol) ENSMUST00000101893.1 ENSMUST00000101893.2 ENSMUST00000101893.3 uc291ypt.1 uc291ypt.2 uc291ypt.1 uc291ypt.2 
ENSMUST00000101903.3 Gm23730 ENSMUST00000101903.3 Gm23730 (from geneSymbol) DQ558729 ENSMUST00000101903.1 ENSMUST00000101903.2 uc291qed.1 uc291qed.2 uc291qed.1 uc291qed.2 
ENSMUST00000101925.2 n-R5s1 ENSMUST00000101925.2 n-R5s1 (from geneSymbol) AB352541 ENSMUST00000101925.1 uc292rvt.1 uc292rvt.2 uc292rvt.1 uc292rvt.2 
ENSMUST00000101927.3 Snord14d ENSMUST00000101927.3 small nucleolar RNA, C/D box 14D (from RefSeq NR_028274.1) ENSMUST00000101927.1 ENSMUST00000101927.2 NR_028274 uc057lzi.1 uc057lzi.2 uc057lzi.3 uc057lzi.1 uc057lzi.2 uc057lzi.3 
ENSMUST00000101953.3 Gm23941 ENSMUST00000101953.3 Gm23941 (from geneSymbol) DQ558729 ENSMUST00000101953.1 ENSMUST00000101953.2 uc290kxy.1 uc290kxy.2 uc290kxy.1 uc290kxy.2 
ENSMUST00000101956.3 Gm23942 ENSMUST00000101956.3 Gm23942 (from geneSymbol) ENSMUST00000101956.1 ENSMUST00000101956.2 uc291kze.1 uc291kze.2 uc291kze.1 uc291kze.2 
ENSMUST00000101958.3 Gm23940 ENSMUST00000101958.3 Gm23940 (from geneSymbol) ENSMUST00000101958.1 ENSMUST00000101958.2 uc289pxp.1 uc289pxp.2 uc289pxp.1 uc289pxp.2 
ENSMUST00000101960.3 Gm24142 ENSMUST00000101960.3 Gm24142 (from geneSymbol) ENSMUST00000101960.1 ENSMUST00000101960.2 uc288ezi.1 uc288ezi.2 uc288ezi.1 uc288ezi.2 
ENSMUST00000101978.3 Gm25431 ENSMUST00000101978.3 Gm25431 (from geneSymbol) DQ558729 ENSMUST00000101978.1 ENSMUST00000101978.2 uc289pwz.1 uc289pwz.2 uc289pwz.1 uc289pwz.2 
ENSMUST00000101982.3 Gm24423 ENSMUST00000101982.3 Gm24423 (from geneSymbol) ENSMUST00000101982.1 ENSMUST00000101982.2 uc291yqk.1 uc291yqk.2 uc291yqk.1 uc291yqk.2 
ENSMUST00000101992.3 Gm25087 ENSMUST00000101992.3 Gm25087 (from geneSymbol) ENSMUST00000101992.1 ENSMUST00000101992.2 uc291qrw.1 uc291qrw.2 uc291qrw.1 uc291qrw.2 
ENSMUST00000101993.4 Gm24463 ENSMUST00000101993.4 Gm24463 (from geneSymbol) ENSMUST00000101993.1 ENSMUST00000101993.2 ENSMUST00000101993.3 uc292jml.1 uc292jml.2 uc292jml.1 uc292jml.2 
ENSMUST00000101994.4 Gm24095 ENSMUST00000101994.4 Gm24095 (from geneSymbol) ENSMUST00000101994.1 ENSMUST00000101994.2 ENSMUST00000101994.3 uc288npb.1 uc288npb.2 uc288npb.1 uc288npb.2 
ENSMUST00000101995.3 Gm25647 ENSMUST00000101995.3 Gm25647 (from geneSymbol) ENSMUST00000101995.1 ENSMUST00000101995.2 uc291qqq.1 uc291qqq.2 uc291qqq.1 uc291qqq.2 
ENSMUST00000102000.3 Gm23422 ENSMUST00000102000.3 Gm23422 (from geneSymbol) ENSMUST00000102000.1 ENSMUST00000102000.2 uc287izt.1 uc287izt.2 uc287izt.1 uc287izt.2 
ENSMUST00000102015.3 Gm25089 ENSMUST00000102015.3 Gm25089 (from geneSymbol) ENSMUST00000102015.1 ENSMUST00000102015.2 uc291qri.1 uc291qri.2 uc291qri.1 uc291qri.2 
ENSMUST00000102021.3 Gm25088 ENSMUST00000102021.3 Gm25088 (from geneSymbol) ENSMUST00000102021.1 ENSMUST00000102021.2 uc291qpv.1 uc291qpv.2 uc291qpv.1 uc291qpv.2 
ENSMUST00000102029.3 Gm24121 ENSMUST00000102029.3 Gm24121 (from geneSymbol) ENSMUST00000102029.1 ENSMUST00000102029.2 uc290wtu.1 uc290wtu.2 uc290wtu.1 uc290wtu.2 
ENSMUST00000102033.4 Gm26504 ENSMUST00000102033.4 predicted gene, 26504 (from RefSeq NR_002895.2) ENSMUST00000102033.1 ENSMUST00000102033.2 ENSMUST00000102033.3 NR_002895 uc012flo.1 uc012flo.2 uc012flo.3 uc012flo.1 uc012flo.2 uc012flo.3 
ENSMUST00000102051.3 Mir547 ENSMUST00000102051.3 microRNA 547 (from RefSeq NR_030265.1) ENSMUST00000102051.1 ENSMUST00000102051.2 NR_030265 uc012hjd.1 uc012hjd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609535.1 [ECO:0000345] ##Evidence-Data-END## uc012hjd.1 uc012hjd.2 
ENSMUST00000102052.4 Mir376c ENSMUST00000102052.4 microRNA 376c (from RefSeq NR_030270.1) ENSMUST00000102052.1 ENSMUST00000102052.2 ENSMUST00000102052.3 NR_030270 uc011ytn.1 uc011ytn.2 uc011ytn.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609540.1 [ECO:0000345] ##Evidence-Data-END## uc011ytn.1 uc011ytn.2 uc011ytn.3 
ENSMUST00000102055.3 Mir688 ENSMUST00000102055.3 microRNA 688 (from RefSeq NR_030460.1) ENSMUST00000102055.1 ENSMUST00000102055.2 NR_030460 uc012aad.1 uc012aad.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012aad.1 uc012aad.2 
ENSMUST00000102056.3 Mir615 ENSMUST00000102056.3 microRNA 615 (from RefSeq NR_030526.1) ENSMUST00000102056.1 ENSMUST00000102056.2 NR_030526 uc012aag.1 uc012aag.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609766.1 [ECO:0000345] ##Evidence-Data-END## uc012aag.1 uc012aag.2 
ENSMUST00000102057.3 Mir652 ENSMUST00000102057.3 microRNA 652 (from RefSeq NR_030523.1) ENSMUST00000102057.1 ENSMUST00000102057.2 NR_030523 uc057asy.1 uc057asy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc057asy.1 uc057asy.2 
ENSMUST00000102058.3 Mir705 ENSMUST00000102058.3 microRNA 705 (from RefSeq NR_030486.1) ENSMUST00000102058.1 ENSMUST00000102058.2 NR_030486 uc012eoe.1 uc012eoe.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012eoe.1 uc012eoe.2 
ENSMUST00000102060.3 Mir669a-2 ENSMUST00000102060.3 microRNA 669a-2 (from RefSeq NR_030470.1) ENSMUST00000102060.1 ENSMUST00000102060.2 NR_030470 uc012bqm.1 uc012bqm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012bqm.1 uc012bqm.2 
ENSMUST00000102074.3 Mir669a-3 ENSMUST00000102074.3 microRNA 669a-3 (from RefSeq NR_030471.1) ENSMUST00000102074.1 ENSMUST00000102074.2 NR_030471 uc012bph.1 uc012bph.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012bph.1 uc012bph.2 
ENSMUST00000102079.3 Mir692-3 ENSMUST00000102079.3 microRNA 692-3 (from RefSeq NR_035409.1) ENSMUST00000102079.1 ENSMUST00000102079.2 NR_035409 uc033gmm.1 uc033gmm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gmm.1 uc033gmm.2 
ENSMUST00000102087.3 Mir20b ENSMUST00000102087.3 microRNA 20b (from RefSeq NR_030273.1) ENSMUST00000102087.1 ENSMUST00000102087.2 NR_030273 uc012hhg.1 uc012hhg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609543.1 [ECO:0000345] ##Evidence-Data-END## uc012hhg.1 uc012hhg.2 
ENSMUST00000102088.3 Mir710 ENSMUST00000102088.3 microRNA 710 (from RefSeq NR_030491.1) ENSMUST00000102088.1 ENSMUST00000102088.2 NR_030491 uc012geh.1 uc012geh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012geh.1 uc012geh.2 
ENSMUST00000102089.3 Mir467b ENSMUST00000102089.3 microRNA 467b (from RefSeq NR_030472.1) ENSMUST00000102089.1 ENSMUST00000102089.2 NR_030472 uc012bpp.1 uc012bpp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609693.1 [ECO:0000345] ##Evidence-Data-END## uc012bpp.1 uc012bpp.2 
ENSMUST00000102094.6 Mir598 ENSMUST00000102094.6 microRNA 598 (from RefSeq NR_030611.1) ENSMUST00000102094.1 ENSMUST00000102094.2 ENSMUST00000102094.3 ENSMUST00000102094.4 ENSMUST00000102094.5 NR_030611 uc011znj.1 uc011znj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609962.1 [ECO:0000345] ##Evidence-Data-END## uc011znj.1 uc011znj.2 
ENSMUST00000102095.3 Mir450b ENSMUST00000102095.3 microRNA 450b (from RefSeq NR_030498.1) ENSMUST00000102095.1 ENSMUST00000102095.2 NR_030498 uc012hhj.1 uc012hhj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609709.1 [ECO:0000345] ##Evidence-Data-END## uc012hhj.1 uc012hhj.2 
ENSMUST00000102096.3 Mir707 ENSMUST00000102096.3 microRNA 707 (from RefSeq NR_030488.1) ENSMUST00000102096.1 ENSMUST00000102096.2 NR_030488 uc012fjw.1 uc012fjw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012fjw.1 uc012fjw.2 
ENSMUST00000102097.3 Mir541 ENSMUST00000102097.3 microRNA 541 (from RefSeq NR_030263.1) ENSMUST00000102097.1 ENSMUST00000102097.2 NR_030263 uc011yug.1 uc011yug.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609533.1 [ECO:0000345] ##Evidence-Data-END## uc011yug.1 uc011yug.2 
ENSMUST00000102105.3 Mir546 ENSMUST00000102105.3 microRNA 546 (from RefSeq NR_030259.1) ENSMUST00000102105.1 ENSMUST00000102105.2 NR_030259 uc011xpk.1 uc011xpk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011xpk.1 uc011xpk.2 
ENSMUST00000102106.3 Mir704 ENSMUST00000102106.3 microRNA 704 (from RefSeq NR_030485.1) ENSMUST00000102106.1 ENSMUST00000102106.2 NR_030485 uc012elb.1 uc012elb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609704.1 [ECO:0000345] ##Evidence-Data-END## uc012elb.1 uc012elb.2 
ENSMUST00000102108.3 Mir92-1 ENSMUST00000102108.3 microRNA 92-1 (from RefSeq NR_029816.1) ENSMUST00000102108.1 ENSMUST00000102108.2 NR_029816 uc288wla.1 uc288wla.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608646.1 [ECO:0000345] ##Evidence-Data-END## uc288wla.1 uc288wla.2 
ENSMUST00000102109.3 Mir539 ENSMUST00000102109.3 microRNA 539 (from RefSeq NR_030262.1) ENSMUST00000102109.1 ENSMUST00000102109.2 NR_030262 uc011ytu.1 uc011ytu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609532.1 [ECO:0000345] ##Evidence-Data-END## uc011ytu.1 uc011ytu.2 
ENSMUST00000102110.3 Mir690 ENSMUST00000102110.3 microRNA 690 (from RefSeq NR_030463.1) ENSMUST00000102110.1 ENSMUST00000102110.2 NR_030463 uc012ady.1 uc012ady.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609684.1 [ECO:0000345] ##Evidence-Data-END## uc012ady.1 uc012ady.2 
ENSMUST00000102111.3 Mir681 ENSMUST00000102111.3 microRNA 681 (from RefSeq NR_030450.1) ENSMUST00000102111.1 ENSMUST00000102111.2 NR_030450 uc011ync.1 uc011ync.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011ync.1 uc011ync.2 
ENSMUST00000102112.3 Mir223 ENSMUST00000102112.3 microRNA 223 (from RefSeq NR_029801.1) ENSMUST00000102112.1 ENSMUST00000102112.2 NR_029801 uc012hmk.1 uc012hmk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608631.1 [ECO:0000345] ##Evidence-Data-END## uc012hmk.1 uc012hmk.2 
ENSMUST00000102113.3 Mir592 ENSMUST00000102113.3 microRNA 592 (from RefSeq NR_030420.1) ENSMUST00000102113.1 ENSMUST00000102113.2 NR_030420 uc012eir.1 uc012eir.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609647.1 [ECO:0000345] ##Evidence-Data-END## uc012eir.1 uc012eir.2 
ENSMUST00000102114.3 Mir678 ENSMUST00000102114.3 microRNA 678 (from RefSeq NR_030443.1) ENSMUST00000102114.1 ENSMUST00000102114.2 NR_030443 uc011xgx.1 uc011xgx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011xgx.1 uc011xgx.2 
ENSMUST00000102164.3 Mir698 ENSMUST00000102164.3 microRNA 698 (from RefSeq NR_030480.1) ENSMUST00000102164.1 ENSMUST00000102164.2 NR_030480 uc012dkw.1 uc012dkw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609699.1 [ECO:0000345] ##Evidence-Data-END## uc012dkw.1 uc012dkw.2 
ENSMUST00000102165.3 Mir551b ENSMUST00000102165.3 microRNA 551b (from RefSeq NR_030422.1) ENSMUST00000102165.1 ENSMUST00000102165.2 NR_030422 uc012coe.1 uc012coe.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609650.1 [ECO:0000345] ##Evidence-Data-END## uc012coe.1 uc012coe.2 
ENSMUST00000102166.3 Mir687 ENSMUST00000102166.3 microRNA 687 (from RefSeq NR_030459.1) ENSMUST00000102166.1 ENSMUST00000102166.2 NR_030459 uc011zol.1 uc011zol.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011zol.1 uc011zol.2 
ENSMUST00000102167.4 Mir540 ENSMUST00000102167.4 microRNA 540 (from RefSeq NR_030260.1) ENSMUST00000102167.1 ENSMUST00000102167.2 ENSMUST00000102167.3 NR_030260 uc011ysg.1 uc011ysg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609530.1 [ECO:0000345] ##Evidence-Data-END## uc011ysg.1 uc011ysg.2 
ENSMUST00000102168.3 Mir503 ENSMUST00000102168.3 microRNA 503 (from RefSeq NR_030275.1) ENSMUST00000102168.1 ENSMUST00000102168.2 NR_030275 uc012hho.1 uc012hho.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609545.1 [ECO:0000345] ##Evidence-Data-END## uc012hho.1 uc012hho.2 
ENSMUST00000102169.3 Mir700 ENSMUST00000102169.3 microRNA 700 (from RefSeq NR_030481.1) ENSMUST00000102169.1 ENSMUST00000102169.2 NR_030481 uc012dna.1 uc012dna.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609700.1 [ECO:0000345] ##Evidence-Data-END## uc012dna.1 uc012dna.2 
ENSMUST00000102172.3 Mir669b ENSMUST00000102172.3 microRNA 669b (from RefSeq NR_030469.1) ENSMUST00000102172.1 ENSMUST00000102172.2 NR_030469 uc056zjl.1 uc056zjl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zjl.1 uc056zjl.2 
ENSMUST00000102173.3 Mir718 ENSMUST00000102173.3 microRNA 718 (from RefSeq NR_030758.1) ENSMUST00000102173.1 ENSMUST00000102173.2 NR_030758 uc012hko.1 uc012hko.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012hko.1 uc012hko.2 
ENSMUST00000102174.3 Mir686 ENSMUST00000102174.3 microRNA 686 (from RefSeq NR_030457.1) ENSMUST00000102174.1 ENSMUST00000102174.2 NR_030457 uc011zlb.1 uc011zlb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011zlb.1 uc011zlb.2 
ENSMUST00000102184.3 Gm26377 ENSMUST00000102184.3 Gm26377 (from geneSymbol) AK206186 ENSMUST00000102184.1 ENSMUST00000102184.2 uc292jax.1 uc292jax.2 uc292jax.1 uc292jax.2 
ENSMUST00000102186.3 Mir542 ENSMUST00000102186.3 microRNA 542 (from RefSeq NR_030264.1) ENSMUST00000102186.1 ENSMUST00000102186.2 NR_030264 uc012hhm.1 uc012hhm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609534.1 [ECO:0000345] ##Evidence-Data-END## uc012hhm.1 uc012hhm.2 
ENSMUST00000102187.3 Mir693 ENSMUST00000102187.3 microRNA 693 (from RefSeq NR_030466.1) ENSMUST00000102187.1 ENSMUST00000102187.2 NR_030466 uc012aum.1 uc012aum.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609687.1 [ECO:0000345] ##Evidence-Data-END## uc012aum.1 uc012aum.2 
ENSMUST00000102188.3 Mir711 ENSMUST00000102188.3 microRNA 711 (from RefSeq NR_030492.1) ENSMUST00000102188.1 ENSMUST00000102188.2 NR_030492 uc012haw.1 uc012haw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012haw.1 uc012haw.2 
ENSMUST00000102189.3 Mir708 ENSMUST00000102189.3 microRNA 708 (from RefSeq NR_030489.1) ENSMUST00000102189.1 ENSMUST00000102189.2 NR_030489 uc012fpf.1 uc012fpf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc012fpf.1 uc012fpf.2 
ENSMUST00000102190.3 Mir709 ENSMUST00000102190.3 microRNA 709 (from RefSeq NR_030490.1) ENSMUST00000102190.1 ENSMUST00000102190.2 NR_030490 uc012ggz.1 uc012ggz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609706.1 [ECO:0000345] ##Evidence-Data-END## uc012ggz.1 uc012ggz.2 
ENSMUST00000102191.3 Mir679 ENSMUST00000102191.3 microRNA 679 (from RefSeq NR_030445.1) ENSMUST00000102191.1 ENSMUST00000102191.2 NR_030445 uc011yth.1 uc011yth.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609681.1 [ECO:0000345] ##Evidence-Data-END## uc011yth.1 uc011yth.2 
ENSMUST00000102192.3 Mir449c ENSMUST00000102192.3 microRNA 449c (from RefSeq NR_030452.1) ENSMUST00000102192.1 ENSMUST00000102192.2 NR_030452 uc011zer.1 uc011zer.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609683.1 [ECO:0000345] ##Evidence-Data-END## uc011zer.1 uc011zer.2 
ENSMUST00000102193.3 Mir694 ENSMUST00000102193.3 microRNA 694 (from RefSeq NR_030467.1) ENSMUST00000102193.1 ENSMUST00000102193.2 NR_030467 uc012bef.1 uc012bef.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609688.1 [ECO:0000345] ##Evidence-Data-END## uc012bef.1 uc012bef.2 
ENSMUST00000102207.3 Mir467a-1 ENSMUST00000102207.3 microRNA 467a-1 (from RefSeq NR_035406.1) ENSMUST00000102207.1 ENSMUST00000102207.2 NR_035406 uc056zjs.1 uc056zjs.2 uc056zjs.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609391.1, LM610922.1 [ECO:0000345] ##Evidence-Data-END## uc056zjs.1 uc056zjs.2 uc056zjs.3 
ENSMUST00000102208.3 Mir701 ENSMUST00000102208.3 microRNA 701 (from RefSeq NR_030482.1) ENSMUST00000102208.1 ENSMUST00000102208.2 NR_030482 uc012ebd.1 uc012ebd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609701.1 [ECO:0000345] ##Evidence-Data-END## uc012ebd.1 uc012ebd.2 
ENSMUST00000102257.3 Mir680-1 ENSMUST00000102257.3 microRNA 680-1 (from RefSeq NR_030447.1) ENSMUST00000102257.1 ENSMUST00000102257.2 NR_030447 uc057aeu.1 uc057aeu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057aeu.1 uc057aeu.2 
ENSMUST00000102259.3 Mir717 ENSMUST00000102259.3 microRNA 717 (from RefSeq NR_030497.1) ENSMUST00000102259.1 ENSMUST00000102259.2 NR_030497 uc012hhc.1 uc012hhc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012hhc.1 uc012hhc.2 
ENSMUST00000102261.3 Mir695 ENSMUST00000102261.3 microRNA 695 (from RefSeq NR_030475.1) ENSMUST00000102261.1 ENSMUST00000102261.2 NR_030475 uc012chb.1 uc012chb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012chb.1 uc012chb.2 
ENSMUST00000102262.3 Mir706 ENSMUST00000102262.3 microRNA 706 (from RefSeq NR_030487.1) ENSMUST00000102262.1 ENSMUST00000102262.2 NR_030487 uc012erw.1 uc012erw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012erw.1 uc012erw.2 
ENSMUST00000102263.3 Mir692-1 ENSMUST00000102263.3 microRNA 692-1 (from RefSeq NR_030465.1) ENSMUST00000102263.1 ENSMUST00000102263.2 NR_030465 uc012ajl.1 uc012ajl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609685.1 [ECO:0000345] ##Evidence-Data-END## uc012ajl.1 uc012ajl.2 
ENSMUST00000102265.3 Mir487b ENSMUST00000102265.3 microRNA 487b (from RefSeq NR_030271.1) ENSMUST00000102265.1 ENSMUST00000102265.2 NR_030271 uc011ytt.1 uc011ytt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609541.1 [ECO:0000345] ##Evidence-Data-END## uc011ytt.1 uc011ytt.2 
ENSMUST00000102268.3 Mir297b ENSMUST00000102268.3 microRNA 297b (from RefSeq NR_030474.1) ENSMUST00000102268.1 ENSMUST00000102268.2 NR_030474 uc057lbx.1 uc057lbx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lbx.1 uc057lbx.2 
ENSMUST00000102281.3 Mir682 ENSMUST00000102281.3 microRNA 682 (from RefSeq NR_030451.1) ENSMUST00000102281.1 ENSMUST00000102281.2 NR_030451 uc011zbz.1 uc011zbz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011zbz.1 uc011zbz.2 
ENSMUST00000102285.3 Mir702 ENSMUST00000102285.3 microRNA 702 (from RefSeq NR_030483.1) ENSMUST00000102285.1 ENSMUST00000102285.2 NR_030483 uc012eev.1 uc012eev.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609702.1 [ECO:0000345] ##Evidence-Data-END## uc012eev.1 uc012eev.2 
ENSMUST00000102286.4 Mir543 ENSMUST00000102286.4 microRNA 543 (from RefSeq NR_030261.1) ENSMUST00000102286.1 ENSMUST00000102286.2 ENSMUST00000102286.3 NR_030261 uc011ytk.1 uc011ytk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609531.1 [ECO:0000345] ##Evidence-Data-END## uc011ytk.1 uc011ytk.2 
ENSMUST00000102296.3 Mir501 ENSMUST00000102296.3 microRNA 501 (from RefSeq NR_030496.1) ENSMUST00000102296.1 ENSMUST00000102296.2 NR_030496 uc012hdz.1 uc012hdz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609708.1 [ECO:0000345] ##Evidence-Data-END## uc012hdz.1 uc012hdz.2 
ENSMUST00000102297.3 Mir302b ENSMUST00000102297.3 microRNA 302b (from RefSeq NR_030403.1) ENSMUST00000102297.1 ENSMUST00000102297.2 NR_030403 uc012cxh.1 uc012cxh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609615.1 [ECO:0000345] ##Evidence-Data-END## uc012cxh.1 uc012cxh.2 
ENSMUST00000102298.3 Mir680-3 ENSMUST00000102298.3 microRNA 680-3 (from RefSeq NR_030449.1) ENSMUST00000102298.1 ENSMUST00000102298.2 NR_030449 uc056yqb.1 uc056yqb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yqb.1 uc056yqb.2 
ENSMUST00000102300.4 Mir92b ENSMUST00000102300.4 microRNA 92b (from RefSeq NR_030579.1) ENSMUST00000102300.1 ENSMUST00000102300.2 ENSMUST00000102300.3 NR_030579 uc012csk.1 uc012csk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609943.1 [ECO:0000345] ##Evidence-Data-END## uc012csk.1 uc012csk.2 
ENSMUST00000102301.3 Mir19b-1 ENSMUST00000102301.3 microRNA 19b-1 (from RefSeq NR_029815.1) ENSMUST00000102301.1 ENSMUST00000102301.2 NR_029815 uc011zpx.1 uc011zpx.2 uc011zpx.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608645.1 [ECO:0000345] ##Evidence-Data-END## uc011zpx.1 uc011zpx.2 uc011zpx.3 
ENSMUST00000102314.3 Mir374b ENSMUST00000102314.3 microRNA 374b (from RefSeq NR_030418.1) ENSMUST00000102314.1 ENSMUST00000102314.2 NR_030418 uc012hng.1 uc012hng.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609645.1 [ECO:0000345] ##Evidence-Data-END## uc012hng.1 uc012hng.2 
ENSMUST00000102315.3 Mir719 ENSMUST00000102315.3 microRNA 719 (from RefSeq NR_030458.1) ENSMUST00000102315.1 ENSMUST00000102315.2 NR_030458 uc288uyv.1 uc288uyv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288uyv.1 uc288uyv.2 
ENSMUST00000102316.3 Mir697 ENSMUST00000102316.3 microRNA 697 (from RefSeq NR_030479.1) ENSMUST00000102316.1 ENSMUST00000102316.2 NR_030479 uc012dku.1 uc012dku.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012dku.1 uc012dku.2 
ENSMUST00000102317.3 Mir666 ENSMUST00000102317.3 microRNA 666 (from RefSeq NR_030435.1) ENSMUST00000102317.1 ENSMUST00000102317.2 NR_030435 uc011ytj.1 uc011ytj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609671.1 [ECO:0000345] ##Evidence-Data-END## uc011ytj.1 uc011ytj.2 
ENSMUST00000102320.3 Mir675 ENSMUST00000102320.3 microRNA 675 (from RefSeq NR_030416.1) ENSMUST00000102320.1 ENSMUST00000102320.2 NR_030416 uc057cbi.1 uc057cbi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609643.1 [ECO:0000345] ##Evidence-Data-END## uc057cbi.1 uc057cbi.2 
ENSMUST00000102331.3 Mir672 ENSMUST00000102331.3 microRNA 672 (from RefSeq NR_030430.1) ENSMUST00000102331.1 ENSMUST00000102331.2 NR_030430 uc012hnj.1 uc012hnj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609661.1 [ECO:0000345] ##Evidence-Data-END## uc012hnj.1 uc012hnj.2 
ENSMUST00000102333.3 Mir301b ENSMUST00000102333.3 microRNA 301b (from RefSeq NR_030415.1) ENSMUST00000102333.1 ENSMUST00000102333.2 NR_030415 uc012abp.1 uc012abp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609642.1 [ECO:0000345] ##Evidence-Data-END## uc012abp.1 uc012abp.2 
ENSMUST00000102354.4 Mir147 ENSMUST00000102354.4 microRNA 147 (from RefSeq NR_030547.1) ENSMUST00000102354.1 ENSMUST00000102354.2 ENSMUST00000102354.3 NR_030547 uc012ccy.1 uc012ccy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609916.1 [ECO:0000345] ##Evidence-Data-END## uc012ccy.1 uc012ccy.2 
ENSMUST00000102357.3 Mir499 ENSMUST00000102357.3 microRNA 499 (from RefSeq NR_030757.1) ENSMUST00000102357.1 ENSMUST00000102357.2 NR_030757 uc012chd.1 uc012chd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609696.1 [ECO:0000345] ##Evidence-Data-END## uc012chd.1 uc012chd.2 
ENSMUST00000102358.3 Mir665 ENSMUST00000102358.3 microRNA 665 (from RefSeq NR_030425.1) ENSMUST00000102358.1 ENSMUST00000102358.2 NR_030425 uc011ysh.1 uc011ysh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609655.1 [ECO:0000345] ##Evidence-Data-END## uc011ysh.1 uc011ysh.2 
ENSMUST00000102360.4 Mir343 ENSMUST00000102360.4 microRNA 343 (from RefSeq NR_030759.1) ENSMUST00000102360.1 ENSMUST00000102360.2 ENSMUST00000102360.3 NR_030759 uc012fbd.1 uc012fbd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012fbd.1 uc012fbd.2 
ENSMUST00000102361.3 Mir673 ENSMUST00000102361.3 microRNA 673 (from RefSeq NR_030438.1) ENSMUST00000102361.1 ENSMUST00000102361.2 NR_030438 uc011ysd.1 uc011ysd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609673.1 [ECO:0000345] ##Evidence-Data-END## uc011ysd.1 uc011ysd.2 
ENSMUST00000102363.3 Mir216b ENSMUST00000102363.3 microRNA 216b (from RefSeq NR_030419.1) ENSMUST00000102363.1 ENSMUST00000102363.2 NR_030419 uc011xsl.1 uc011xsl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609646.1 [ECO:0000345] ##Evidence-Data-END## uc011xsl.1 uc011xsl.2 
ENSMUST00000102378.3 Mir599 ENSMUST00000102378.3 microRNA 599 (from RefSeq NR_035527.1) ENSMUST00000102378.1 ENSMUST00000102378.2 NR_035527 uc011zsb.1 uc011zsb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011zsb.1 uc011zsb.2 
ENSMUST00000102380.3 Mir670 ENSMUST00000102380.3 microRNA 670 (from RefSeq NR_030431.1) ENSMUST00000102380.1 ENSMUST00000102380.2 NR_030431 uc012caa.1 uc012caa.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609662.1 [ECO:0000345] ##Evidence-Data-END## uc012caa.1 uc012caa.2 
ENSMUST00000102383.3 Mir181d ENSMUST00000102383.3 microRNA 181d (from RefSeq NR_030534.1) ENSMUST00000102383.1 ENSMUST00000102383.2 NR_030534 uc012ghb.1 uc012ghb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609889.1 [ECO:0000345] ##Evidence-Data-END## uc012ghb.1 uc012ghb.2 
ENSMUST00000102402.3 Mir653 ENSMUST00000102402.3 microRNA 653 (from RefSeq NR_030612.1) ENSMUST00000102402.1 ENSMUST00000102402.2 NR_030612 uc012ehs.1 uc012ehs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609963.1 [ECO:0000345] ##Evidence-Data-END## uc012ehs.1 uc012ehs.2 
ENSMUST00000102406.3 Mir182 ENSMUST00000102406.3 microRNA 182 (from RefSeq NR_029569.1) ENSMUST00000102406.1 ENSMUST00000102406.2 NR_029569 uc012ejh.1 uc012ejh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608304.1 [ECO:0000345] ##Evidence-Data-END## uc012ejh.1 uc012ejh.2 
ENSMUST00000102417.4 Mir568 ENSMUST00000102417.4 microRNA 568 (from RefSeq NR_030576.1) ENSMUST00000102417.1 ENSMUST00000102417.2 ENSMUST00000102417.3 NR_030576 uc012afr.1 uc012afr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012afr.1 uc012afr.2 
ENSMUST00000102421.3 Mir674 ENSMUST00000102421.3 microRNA 674 (from RefSeq NR_030440.1) ENSMUST00000102421.1 ENSMUST00000102421.2 NR_030440 uc008lrj.1 uc008lrj.2 uc008lrj.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609675.1 [ECO:0000345] ##Evidence-Data-END## uc008lrj.1 uc008lrj.2 uc008lrj.3 
ENSMUST00000102422.4 Gm54624 ENSMUST00000102422.4 Gm54624 (from geneSymbol) ENSMUST00000102422.1 ENSMUST00000102422.2 ENSMUST00000102422.3 LF262441 uc287qfz.1 uc287qfz.2 uc287qfz.1 uc287qfz.2 
ENSMUST00000102424.4 Mir190a ENSMUST00000102424.4 microRNA 190a (from RefSeq NR_029576.1) ENSMUST00000102424.1 ENSMUST00000102424.2 ENSMUST00000102424.3 NR_029576 uc012gwc.1 uc012gwc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608312.1 [ECO:0000345] ##Evidence-Data-END## uc012gwc.1 uc012gwc.2 
ENSMUST00000102432.3 Mir671 ENSMUST00000102432.3 microRNA 671 (from RefSeq NR_030423.1) ENSMUST00000102432.1 ENSMUST00000102432.2 NR_030423 uc012dtg.1 uc012dtg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609652.1 [ECO:0000345] ##Evidence-Data-END## uc012dtg.1 uc012dtg.2 
ENSMUST00000102441.3 Mir667 ENSMUST00000102441.3 microRNA 667 (from RefSeq NR_030426.1) ENSMUST00000102441.1 ENSMUST00000102441.2 NR_030426 uc011ytm.1 uc011ytm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609656.1 [ECO:0000345] ##Evidence-Data-END## uc011ytm.1 uc011ytm.2 
ENSMUST00000102443.3 Mir676 ENSMUST00000102443.3 microRNA 676 (from RefSeq NR_030525.1) ENSMUST00000102443.1 ENSMUST00000102443.2 NR_030525 uc012hmr.1 uc012hmr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609765.1 [ECO:0000345] ##Evidence-Data-END## uc012hmr.1 uc012hmr.2 
ENSMUST00000102444.3 Mir450-2 ENSMUST00000102444.3 microRNA 450-2 (from RefSeq NR_030274.1) ENSMUST00000102444.1 ENSMUST00000102444.2 NR_030274 uc012hhl.1 uc012hhl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609544.1 [ECO:0000345] ##Evidence-Data-END## uc012hhl.1 uc012hhl.2 
ENSMUST00000102469.4 Gm25986 ENSMUST00000102469.4 Gm25986 (from geneSymbol) ENSMUST00000102469.1 ENSMUST00000102469.2 ENSMUST00000102469.3 uc289fii.1 uc289fii.2 uc289fii.1 uc289fii.2 
ENSMUST00000102476.5 B2m ENSMUST00000102476.5 beta-2 microglobulin (from RefSeq NM_009735.3) B2MG_MOUSE ENSMUST00000102476.1 ENSMUST00000102476.2 ENSMUST00000102476.3 ENSMUST00000102476.4 NM_009735 P01887 Q91XJ8 uc008maf.1 uc008maf.2 uc008maf.3 Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Forms a heterotrimer with MR1 and a metabolite antigen. Secreted. The following alleles of B2M are known: A, B, W2, W3, W4 and W5 (C). The sequence shown is that of allele B. Belongs to the beta-2-microglobulin family. positive regulation of T cell mediated cytotoxicity response to molecule of bacterial origin immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent positive regulation of T cell cytokine production regulation of membrane depolarization protein binding extracellular region extracellular space Golgi apparatus cytosol plasma membrane iron ion transport immune response cellular defense response multicellular organism development learning or memory external side of plasma membrane negative regulation of neuron projection development antibacterial humoral response antigen processing and presentation of endogenous peptide antigen via MHC class I phagocytic vesicle membrane positive regulation of protein binding T cell differentiation in thymus regulation of iron ion transport protein refolding response to drug MHC class I protein complex identical protein binding protein homodimerization activity MHC class I peptide loading complex innate immune response regulation of erythrocyte differentiation response to cadmium ion positive regulation of receptor-mediated endocytosis negative regulation of epithelial cell proliferation negative regulation of neurogenesis defense response to Gram-negative bacterium defense response to Gram-positive bacterium protein homotetramerization iron ion homeostasis cellular response to lipopolysaccharide cellular response to iron ion cellular response to iron(III) ion cellular response to nicotine modulation of age-related behavioral decline negative regulation of receptor binding positive regulation of receptor binding positive regulation of ferrous iron binding positive regulation of transferrin receptor binding amyloid fibril formation HFE-transferrin receptor complex positive regulation of cellular senescence negative regulation of forebrain neuron differentiation uc008maf.1 uc008maf.2 uc008maf.3 
ENSMUST00000102481.4 Cela2a ENSMUST00000102481.4 chymotrypsin-like elastase family, member 2A (from RefSeq NM_007919.3) CEL2A_MOUSE Cela2a ENSMUST00000102481.1 ENSMUST00000102481.2 ENSMUST00000102481.3 Ela-2 Ela2 Ela2a NM_007919 P05208 uc008vpj.1 uc008vpj.2 uc008vpj.3 This gene encodes a serine protease enzyme that hydrolyzes elastin. This gene is highly expressed in the pancreatic acinar cells where the encoded preproprotein undergoes processing including signal peptide cleavage to generate an inactive zymogen. The removal of N-terminal activation peptide from the zymogen by trypsin generates active elastase enzyme. This gene is also expressed in the mouse epidermis where it participates in pro-filaggrin processing. [provided by RefSeq, Jul 2016]. ##Evidence-Data-START## Transcript exon combination :: X04573.1, BC026552.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. Reaction=Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin.; EC=3.4.21.71; Evidence=; Interacts with CPA1. Interacts with SERPINA1. Secreted Highly expressed in pancreas (at mRNA and protein levels). Also expressed in adrenal gland and small intestine. Belongs to the peptidase S1 family. Elastase subfamily. serine-type endopeptidase activity extracellular region extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity serine hydrolase activity keratohyalin granule uc008vpj.1 uc008vpj.2 uc008vpj.3 
ENSMUST00000102483.5 Rpl23a ENSMUST00000102483.5 ribosomal protein L23A (from RefSeq NM_207523.2) ENSMUST00000102483.1 ENSMUST00000102483.2 ENSMUST00000102483.3 ENSMUST00000102483.4 NM_207523 Q5M9M5 Q5M9M5_MOUSE Rpl23a uc007kil.1 uc007kil.2 uc007kil.3 uc007kil.4 uc007kil.5 Belongs to the universal ribosomal protein uL23 family. structural constituent of ribosome nucleus ribosome translation cell proliferation uc007kil.1 uc007kil.2 uc007kil.3 uc007kil.4 uc007kil.5 
ENSMUST00000102484.5 Ddi2 ENSMUST00000102484.5 DNA-damage inducible protein 2 (from RefSeq NM_001017966.2) A2ADY9 DDI2_MOUSE Ddi2 ENSMUST00000102484.1 ENSMUST00000102484.2 ENSMUST00000102484.3 ENSMUST00000102484.4 NM_001017966 uc008vpd.1 uc008vpd.2 uc008vpd.3 Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity. Homodimer. Cytoplasm, cytosol Chromosome Belongs to the DDI1 family. Although this protein contains the conserved Asp-252 that functions as an active site, this protein does not have proteolytic activity, and may therefore be catalytically inactive. aspartic-type endopeptidase activity nucleoplasm chromosome cytoplasm cytosol proteolysis peptidase activity proteasomal protein catabolic process protein processing hydrolase activity regulation of protein stability identical protein binding ubiquitin binding cellular response to hydroxyurea uc008vpd.1 uc008vpd.2 uc008vpd.3 
ENSMUST00000102486.5 Hspb7 ENSMUST00000102486.5 heat shock protein family, member 7 (cardiovascular) (from RefSeq NM_013868.4) Cvhsp ENSMUST00000102486.1 ENSMUST00000102486.2 ENSMUST00000102486.3 ENSMUST00000102486.4 HSPB7_MOUSE Hsp25-2 NM_013868 P35385 Q5FW72 Q8CDI0 Q9QUS2 uc008voj.1 uc008voj.2 uc008voj.3 Interacts with C-terminal domain of actin-binding protein 280. Cytoplasm Nucleus Nucleus, Cajal body Note=Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. Found in both cardiac and slow skeletal (soleus) muscle. Belongs to the small heat shock protein (HSP20) family. nucleus nucleoplasm cytoplasm mitochondrion heart development response to heat Cajal body actin cytoskeleton aggresome filamin binding uc008voj.1 uc008voj.2 uc008voj.3 
ENSMUST00000102487.4 Szrd1 ENSMUST00000102487.4 SUZ RNA binding domain containing 1, transcript variant 4 (from RefSeq NM_001277195.2) D4Ertd22e ENSMUST00000102487.1 ENSMUST00000102487.2 ENSMUST00000102487.3 NM_001277195 Q3TB72 Q6NXN1 Q8BT36 SZRD1_MOUSE uc008vnw.1 uc008vnw.2 uc008vnw.3 uc008vnw.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NXN1-1; Sequence=Displayed; Name=2; IsoId=Q6NXN1-2; Sequence=VSP_027998; Belongs to the SZRD1 family. molecular_function cellular_component biological_process uc008vnw.1 uc008vnw.2 uc008vnw.3 uc008vnw.4 
ENSMUST00000102490.10 Epb42 ENSMUST00000102490.10 erythrocyte membrane protein band 4.2 (from RefSeq NM_013513.3) ENSMUST00000102490.1 ENSMUST00000102490.2 ENSMUST00000102490.3 ENSMUST00000102490.4 ENSMUST00000102490.5 ENSMUST00000102490.6 ENSMUST00000102490.7 ENSMUST00000102490.8 ENSMUST00000102490.9 EPB42_MOUSE Epb4.2 Epb42 NM_013513 P49222 Q3UP33 uc008lxj.1 uc008lxj.2 uc008lxj.3 uc008lxj.4 The protein encoded by this gene is the key component of a macromolecular complex involved in the structure of erythrocytes. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK143841.1, AK133896.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Component of the ankyrin-1 complex in the erythrocyte, composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1. Interacts with SLC4A1 (via the cytoplasmic domain); this interaction is mediated by the SLC4A1 Band 3-I dimer. Interacts with ANK1 (via ANK 1- 13 repeats). Interacts with AQP1 (via the C-terminal). Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic surface of erythrocyte membranes. The substitution of an Ala for a Cys in the active site may be responsible for the lack of transglutaminase activity of band 4.2. Belongs to the transglutaminase superfamily. Transglutaminase family. Was originally thought to be pallidin. cell morphogenesis protein-glutamine gamma-glutamyltransferase activity cytoplasm cytoskeleton plasma membrane regulation of cell shape membrane peptide cross-linking hemoglobin metabolic process cortical cytoskeleton erythrocyte maturation spleen development ion homeostasis iron ion homeostasis uc008lxj.1 uc008lxj.2 uc008lxj.3 uc008lxj.4 
ENSMUST00000102491.10 Crocc ENSMUST00000102491.10 ciliary rootlet coiled-coil, rootletin, transcript variant 1 (from RefSeq NM_172122.3) A2AA81 CROCC_MOUSE Crocc ENSMUST00000102491.1 ENSMUST00000102491.2 ENSMUST00000102491.3 ENSMUST00000102491.4 ENSMUST00000102491.5 ENSMUST00000102491.6 ENSMUST00000102491.7 ENSMUST00000102491.8 ENSMUST00000102491.9 Kiaa0445 NM_172122 Q7TQL2 Q80U01 Q8CJ40 Q8R0B9 uc008vns.1 uc008vns.2 uc008vns.3 uc008vns.4 Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (PubMed:12427867). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (By similarity). Contributes to centrosome cohesion before mitosis (By similarity). Homomer. Interacts with KLC3, NEK2 and the N-terminus of CEP250 (PubMed:12427867, PubMed:16339073). Interacts with CEP44 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole toplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase. Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q8CJ40-1; Sequence=Displayed; Name=2 ; IsoId=Q8CJ40-2; Sequence=VSP_052066, VSP_052067; Name=3 ; IsoId=Q8CJ40-3; Sequence=VSP_052068; Highest expression detected in photoreceptor cells of retina. Expressed at lower levels in brain, trachea and kidney. Detected in all major ciliated epithelia. During embryonic development, enriched along the apical domains of neuroepithelium in brain ventricular zone, in primordia of retinal pigment epithelia and in neural retina. Phosphorylated by NEK2 which may regulate its association with centrosomes. Mice have no ciliary rootlets in ciliated cells. Belongs to the rootletin family. Sequence=AAH27090.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; photoreceptor inner segment actin binding structural molecule activity structural constituent of cytoskeleton protein binding cytoplasm centrosome centriole microtubule organizing center cytosol cytoskeleton plasma membrane cilium cell cycle centrosome cycle protein localization centriole-centriole cohesion epithelial structure maintenance actin cytoskeleton kinesin binding cell projection organization ciliary basal body organization protein localization to organelle ciliary rootlet cell projection photoreceptor cell maintenance positive regulation of cilium assembly establishment of organelle localization positive regulation of protein localization to cilium uc008vns.1 uc008vns.2 uc008vns.3 uc008vns.4 
ENSMUST00000102494.8 Nsrp1 ENSMUST00000102494.8 nuclear speckle regulatory protein 1 (from RefSeq NM_001012309.2) Ccdc55 ENSMUST00000102494.1 ENSMUST00000102494.2 ENSMUST00000102494.3 ENSMUST00000102494.4 ENSMUST00000102494.5 ENSMUST00000102494.6 ENSMUST00000102494.7 NM_001012309 NSRP1_MOUSE Nsrp70 Q5NCR9 uc007kgg.1 uc007kgg.2 uc007kgg.3 uc007kgg.4 RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Interacts (via C-terminus) with SRSF1. Interacts (via C- terminus) with SRSF2 (By similarity). Nucleus Nucleus speckle Note=Colocalizes with splicing factors SRSF1 and SRSF2 in speckles. Mice show early embryonic lethality shortly after implantation. Belongs to the NSRP1 family. regulation of alternative mRNA splicing, via spliceosome RNA binding mRNA binding nucleus nucleoplasm mRNA processing RNA splicing nuclear speck developmental process ribonucleoprotein complex uc007kgg.1 uc007kgg.2 uc007kgg.3 uc007kgg.4 
ENSMUST00000102495.8 Tmigd1 ENSMUST00000102495.8 transmembrane and immunoglobulin domain containing 1, transcript variant 2 (from RefSeq NM_025655.3) ENSMUST00000102495.1 ENSMUST00000102495.2 ENSMUST00000102495.3 ENSMUST00000102495.4 ENSMUST00000102495.5 ENSMUST00000102495.6 ENSMUST00000102495.7 NM_025655 Q8R202 Q9D7L8 TMIG1_MOUSE Tmigd Tmigd1 uc007kgc.1 uc007kgc.2 uc007kgc.3 May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival. Homodimer. Cell membrane ; Single-pass type I membrane protein Cytoplasm N-glycosylated. molecular_function cytoplasm plasma membrane membrane integral component of membrane regulation of cell migration regulation of cell proliferation negative regulation of apoptotic process regulation of membrane permeability uc007kgc.1 uc007kgc.2 uc007kgc.3 
ENSMUST00000102499.8 Lrrc57 ENSMUST00000102499.8 leucine rich repeat containing 57, transcript variant 5 (from RefSeq NR_027510.1) ENSMUST00000102499.1 ENSMUST00000102499.2 ENSMUST00000102499.3 ENSMUST00000102499.4 ENSMUST00000102499.5 ENSMUST00000102499.6 ENSMUST00000102499.7 Lrrc57 NR_027510 Q8JZX5 Q8JZX5_MOUSE uc008lwk.1 uc008lwk.2 uc008lwk.3 uc008lwk.4 uc008lwk.1 uc008lwk.2 uc008lwk.3 uc008lwk.4 
ENSMUST00000102500.5 Gemin4 ENSMUST00000102500.5 gem nuclear organelle associated protein 4 (from RefSeq NM_177367.3) ENSMUST00000102500.1 ENSMUST00000102500.2 ENSMUST00000102500.3 ENSMUST00000102500.4 Gemin4 NM_177367 Q6P6L6 Q6P6L6_MOUSE uc007kfi.1 uc007kfi.2 uc007kfi.3 uc007kfi.4 spliceosomal snRNP assembly nucleolus cytosol rRNA processing Cajal body nuclear body SMN complex SMN-Sm protein complex ribonucleoprotein complex binding uc007kfi.1 uc007kfi.2 uc007kfi.3 uc007kfi.4 
ENSMUST00000102503.10 Mrto4 ENSMUST00000102503.10 mRNA turnover 4, ribosome maturation factor, transcript variant 3 (from RefSeq NM_001356476.1) ENSMUST00000102503.1 ENSMUST00000102503.2 ENSMUST00000102503.3 ENSMUST00000102503.4 ENSMUST00000102503.5 ENSMUST00000102503.6 ENSMUST00000102503.7 ENSMUST00000102503.8 ENSMUST00000102503.9 MRT4_MOUSE Mrt4 NM_001356476 Q99JR7 Q9D0I8 uc008vme.1 uc008vme.2 uc008vme.3 uc008vme.4 Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. Associates with the pre-60S ribosomal particle. Interacts with MINAS-60 (product of an alternative open reading frame of RBM10). Nucleus, nucleolus Cytoplasm Note=Shuttles between the nucleus and the cytoplasm. Belongs to the universal ribosomal protein uL10 family. ribosomal large subunit assembly nuclear-transcribed mRNA catabolic process nucleus nucleolus cytoplasm rRNA processing preribosome, large subunit precursor ribosome biogenesis ribosomal large subunit biogenesis uc008vme.1 uc008vme.2 uc008vme.3 uc008vme.4 
ENSMUST00000102508.10 Capzb ENSMUST00000102508.10 capping actin protein of muscle Z-line subunit beta, transcript variant 2 (from RefSeq NM_009798.4) Capzb ENSMUST00000102508.1 ENSMUST00000102508.2 ENSMUST00000102508.3 ENSMUST00000102508.4 ENSMUST00000102508.5 ENSMUST00000102508.6 ENSMUST00000102508.7 ENSMUST00000102508.8 ENSMUST00000102508.9 NM_009798 Q923G3 Q923G3_MOUSE uc008vlw.1 uc008vlw.2 uc008vlw.3 uc008vlw.4 This gene encodes the beta subunit of a highly conserved filamentous actin capping protein that binds the barbed end of filamentous actin to stabilize it and terminate elongation. Interaction of this protein with the barbed end of the actin filament occurs through binding of the amphipathic helix at the C-terminus to the hydrophobic cleft on the actin molecule. This gene is required for a variety of dynamic actin-mediated processes including organization of lamellipodia and filopodia, growth cone morphology and neurite outgrowth in hippocampal neurons, and asymmetric spindle migration and polar body extrusion during oocyte maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Heterodimer of an alpha and a beta subunit. Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere Belongs to the F-actin-capping protein beta subunit family. actin binding cytoplasm cytoskeleton F-actin capping protein complex actin cytoskeleton organization barbed-end actin filament capping actin filament capping uc008vlw.1 uc008vlw.2 uc008vlw.3 uc008vlw.4 
ENSMUST00000102513.8 Pla2g5 ENSMUST00000102513.8 Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; (from UniProt Q6GTW1) AK090021 E9PZD1 ENSMUST00000102513.1 ENSMUST00000102513.2 ENSMUST00000102513.3 ENSMUST00000102513.4 ENSMUST00000102513.5 ENSMUST00000102513.6 ENSMUST00000102513.7 Pla2g5 Q6GTW1 Q6GTW1_MOUSE uc290rdf.1 uc290rdf.2 Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Secreted Belongs to the phospholipase A2 family. phospholipase A2 activity calcium ion binding extracellular region Golgi apparatus plasma membrane lipid metabolic process phospholipid metabolic process platelet activating factor biosynthetic process heparin binding positive regulation of phospholipase activity lipid catabolic process hydrolase activity leukotriene biosynthetic process response to cytokine calcium-dependent phospholipase A2 activity perinuclear region of cytoplasm arachidonic acid secretion response to cAMP positive regulation of ERK1 and ERK2 cascade uc290rdf.1 uc290rdf.2 
ENSMUST00000102514.4 Rtn4rl1 ENSMUST00000102514.4 reticulon 4 receptor-like 1 (from RefSeq NM_177708.5) ENSMUST00000102514.1 ENSMUST00000102514.2 ENSMUST00000102514.3 NM_177708 Ngrl2 Q8K0S5 R4RL1_MOUSE Rtn4rl1 uc007kdh.1 uc007kdh.2 uc007kdh.3 Cell surface receptor that plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system (PubMed:22406547, PubMed:27339102). Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (PubMed:26335717). Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans (PubMed:22406547). Binds heparin (PubMed:22406547). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). Identified in a complex that contains RTN4R, RTN4RL1 and NGFR; the interaction depends on the presence of chondroitin sulfate proteoglycans (PubMed:22406547). Does not interact with MAG, OMG and RTN4 (PubMed:12839991). Cell membrane ; Lipid-anchor, GPI-anchor Membrane raft Perikaryon Cell projection Note=Localized to the surface of neurons, including axons. Detected in brain (at protein level) (PubMed:22406547). Detected in retina ganglion cell layer and inner nuclear layer (PubMed:22406547). At 13.5 dpc, strongly expressed in PNS ganglia and developing heart, and weakly expressed in brain and spinal cord. By postnatal day 1, strongly expressed in dorsal root ganglia and in dorsal and gray matter areas of spinal cord. Expressed in various adult brain structures including the amygdala, caudate putamen, cerebellum, cerebral cortex, hippocampus, olfactory bulb and thalamus. No visible phenotype (PubMed:22406547). Mice are born at the expected Mendelian rate, are viable and fertile (PubMed:22406547). Compared to wild-type littermates, cultured hippocampus neurons from mutant mice display an increased number of excitatory synapses (PubMed:22325200). Likewise, mice with a triple gene disruption that lack Rtn4r, Rtn4rl1 and Rtn4rl2 have no visible phenotype, are healthy and viable (PubMed:22406547, PubMed:22325200). Mice with a triple gene disruption that lack Rtn4r, Rtn4rl1 and Rtn4rl2 have normal brain size and grossly normal brain anatomy, but display defects of medial brain structures, including an absence of the fasciola cinereum, corpus callosum agenesis and formation of bilateral Probst bundles indicative of the failure of callosally projecting neurons to extend across the midline (PubMed:27339102). Mice with a triple gene disruption of Rtn4r, Rtn4rl1 and Rtn4rl2 display impaired ability to stay on a rotarod and increased spontaneous locomotion (PubMed:27339102). These mice display an increased number of excitatory synapses in the apical dendritic regions of hippocampus neurons, an increase in the complexity of dendrite structure and increased total dendrite length (PubMed:22325200). One month after birth, mice with a triple gene disruption that lack Rtn4r, Rtn4rl1 and Rtn4rl2 show a significant reduction in the survival of motoneurons (PubMed:26335717). Compared to wild-type or single mutants, cerebellar granule cells from mice lacking Rtn4r, Rtn4rl1 and Rtn4rl2 show decreased myelin-mediated inhibition of neurite outgrowth, an inhibition that is strongly decreased on myelin deficient in Mag, Rtn4 and Omg (PubMed:22406547). Mice lacking both Rtn4r and Rtn4rl1 show increased axon regeneration after injury; the same effect is observed when Rtn4r, Rtn4rl1 and Rtn4rl2 are disrupted (PubMed:22406547). Combined disruption of Rtn4r, Rtn4rl1 and Ptprs further increases axon regeneration after injury (PubMed:22406547). Single gene disruption of Rtn4r, Rtn4rl1 and Rtn4rl2 and combined disruption of Rtn4r and Rtn4rl2 have no effect on axon regeneration (PubMed:22406547). Belongs to the Nogo receptor family. plasma membrane axon guidance heparin binding external side of plasma membrane cell surface negative regulation of neuron projection development membrane integral component of membrane corpus callosum development anchored component of membrane chondroitin sulfate binding signaling receptor activity cell projection perikaryon membrane raft anchored component of plasma membrane Roundabout binding negative regulation of axon regeneration negative chemotaxis uc007kdh.1 uc007kdh.2 uc007kdh.3 
ENSMUST00000102515.10 Prkacb ENSMUST00000102515.10 protein kinase, cAMP dependent, catalytic, beta, transcript variant 1 (from RefSeq NM_011100.5) ENSMUST00000102515.1 ENSMUST00000102515.2 ENSMUST00000102515.3 ENSMUST00000102515.4 ENSMUST00000102515.5 ENSMUST00000102515.6 ENSMUST00000102515.7 ENSMUST00000102515.8 ENSMUST00000102515.9 KAPCB_MOUSE NM_011100 P05206 P68181 Pkacb Q3TQH5 Q3UDD0 Q3UTH5 uc008rrv.1 uc008rrv.2 uc008rrv.3 uc008rrv.4 Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (By similarity). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:9368018). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity). Phosphorylates GPKOW which regulates its ability to bind RNA (By similarity). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.11; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.11; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Activated by cAMP. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Interacts with PRKAR1A and PRKAR2B (By similarity). The cAMP-dependent protein kinase catalytic subunit binds PJA2. Interacts with GPKOW. Cytoplasm Cell membrane Membrane ; Lipid-anchor Nucleus Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Beta1; IsoId=P68181-1; Sequence=Displayed; Name=2; Synonyms=Beta2; IsoId=P68181-2; Sequence=VSP_017373, VSP_017374; Name=3; Synonyms=Beta3; IsoId=P68181-3; Sequence=VSP_017372, VSP_017375; Name=4; IsoId=P68181-4; Sequence=VSP_017376; Isoform 1 is found in all tissues examined, with the highest expression in the brain and very low levels in the testis. Isoform 2 is strongly expressed in the brain, in the prelimbic and insular cortex. Isoform 3 is also found only in the brain, but at very low levels. Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. nucleotide binding magnesium ion binding neural tube closure protein kinase activity protein serine/threonine kinase activity cAMP-dependent protein kinase activity ATP binding nucleus cytoplasm centrosome cytosol plasma membrane cAMP-dependent protein kinase complex protein phosphorylation G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway protein kinase A signaling membrane kinase activity phosphorylation transferase activity ubiquitin protein ligase binding protein kinase A regulatory subunit binding intercellular bridge perinuclear region of cytoplasm negative regulation of meiotic cell cycle regulation of protein processing response to clozapine ciliary base negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning uc008rrv.1 uc008rrv.2 uc008rrv.3 uc008rrv.4 
ENSMUST00000102517.4 Dll4 ENSMUST00000102517.4 delta like canonical Notch ligand 4, transcript variant 1 (from RefSeq NM_019454.4) DLL4_MOUSE ENSMUST00000102517.1 ENSMUST00000102517.2 ENSMUST00000102517.3 NM_019454 Q9DBU9 Q9JHZ7 Q9JI71 uc008ltr.1 uc008ltr.2 uc008ltr.3 uc008ltr.4 Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (By similarity). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (PubMed:22323600). During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity). Interacts with NOTCH4. Interacts (via N-terminal DSL and MNNL domains) with NOTCH1 (via EGF-like domains). Cell membrane ; Single-pass type I membrane protein Expressed in vascular endothelium. Expressed in retina at least during embryogenesis. At 14.5, expressed within the retina outer neuroblastic layer. Conditional knockdowns in retinal progenitors have thinner retinas with occasional regions abnormally organized into rosette-like structures in the outer nuclear layer and an optic nerve with a reduced diameter. negative regulation of transcription from RNA polymerase II promoter angiogenesis branching involved in blood vessel morphogenesis blood vessel remodeling cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis pericardium morphogenesis Notch binding calcium ion binding protein binding plasma membrane integral component of plasma membrane cell communication Notch signaling pathway multicellular organism development nervous system development visual perception negative regulation of cell proliferation negative regulation of endothelial cell migration positive regulation of gene expression negative regulation of gene expression membrane integral component of membrane cell differentiation T cell differentiation dorsal aorta morphogenesis cellular response to vascular endothelial growth factor stimulus negative regulation of blood vessel endothelial cell migration cellular response to fibroblast growth factor stimulus negative regulation of Notch signaling pathway positive regulation of Notch signaling pathway regulation of neurogenesis response to stimulus ventral spinal cord interneuron fate commitment regulation of neural retina development Notch signaling involved in heart development blood vessel lumenization negative regulation of cell migration involved in sprouting angiogenesis negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of neural precursor cell proliferation uc008ltr.1 uc008ltr.2 uc008ltr.3 uc008ltr.4 
ENSMUST00000102518.10 Ece1 ENSMUST00000102518.10 endothelin converting enzyme 1, transcript variant 3 (from RefSeq NM_199307.2) B1AXF9 ECE1_MOUSE ENSMUST00000102518.1 ENSMUST00000102518.2 ENSMUST00000102518.3 ENSMUST00000102518.4 ENSMUST00000102518.5 ENSMUST00000102518.6 ENSMUST00000102518.7 ENSMUST00000102518.8 ENSMUST00000102518.9 NM_199307 Q4PZ99 Q4PZA1 Q4PZA2 Q6P9Q9 uc008vju.1 uc008vju.2 uc008vju.3 Converts big endothelin-1 to endothelin-1. Reaction=Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.; EC=3.4.24.71; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Inhibited by phosphoramidon. Homodimer; disulfide-linked (By similarity). Interacts with PPP1R16B (By similarity). Cell membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=4; Name=B; IsoId=Q4PZA2-1; Sequence=Displayed; Name=A; IsoId=Q4PZA2-2; Sequence=VSP_019399; Name=C; IsoId=Q4PZA2-3; Sequence=VSP_019400; Name=D; IsoId=Q4PZA2-4; Sequence=VSP_019401; Belongs to the peptidase M13 family. response to hypoxia positive regulation of receptor recycling endopeptidase activity metalloendopeptidase activity endosome early endosome Golgi apparatus plasma membrane proteolysis apoptotic process heart development regulation of blood pressure peptidase activity metallopeptidase activity zinc ion binding external side of plasma membrane cell surface positive regulation of cardiac muscle hypertrophy substance P catabolic process bradykinin catabolic process calcitonin catabolic process membrane integral component of membrane protein processing peptide hormone processing hydrolase activity secretory granule cytoplasmic vesicle vesicle Weibel-Palade body endothelin maturation hormone catabolic process embryonic digit morphogenesis protein homodimerization activity ear development positive regulation of cAMP-mediated signaling positive regulation of G-protein coupled receptor protein signaling pathway metal ion binding perinuclear region of cytoplasm pharyngeal system development regulation of ERK1 and ERK2 cascade regulation of blood vessel diameter uc008vju.1 uc008vju.2 uc008vju.3 
ENSMUST00000102521.9 Rap1gap2 ENSMUST00000102521.9 RAP1 GTPase activating protein 2, transcript variant 5 (from RefSeq NM_001401658.1) ENSMUST00000102521.1 ENSMUST00000102521.2 ENSMUST00000102521.3 ENSMUST00000102521.4 ENSMUST00000102521.5 ENSMUST00000102521.6 ENSMUST00000102521.7 ENSMUST00000102521.8 Garnl4 Kiaa1039 NM_001401658 Q3KNA3 Q3V3L0 Q5SVL6 Q80TL8 RPGP2_MOUSE Rap1ga2 uc007kbx.1 uc007kbx.2 uc007kbx.3 GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP- bound state. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SVL6-1; Sequence=Displayed; Name=2; IsoId=Q5SVL6-2; Sequence=VSP_029890, VSP_029952; Sequence=BAC65706.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC65706.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; GTPase activator activity cytoplasm centrosome cytosol plasma membrane regulation of cell size negative regulation of neuron projection development nuclear membrane neuron projection positive regulation of GTPase activity regulation of small GTPase mediated signal transduction uc007kbx.1 uc007kbx.2 uc007kbx.3 
ENSMUST00000102522.5 Cela3b ENSMUST00000102522.5 chymotrypsin-like elastase family, member 3B (from RefSeq NM_026419.2) CEL3B_MOUSE ENSMUST00000102522.1 ENSMUST00000102522.2 ENSMUST00000102522.3 ENSMUST00000102522.4 Ela3 Ela3b NM_026419 Q7TNI0 Q9CQ52 Q9D7T9 uc008vja.1 uc008vja.2 uc008vja.3 Efficient protease with alanine specificity but only little elastolytic activity. Reaction=Preferential cleavage: Ala-|-Xaa. Does not hydrolyze elastin.; EC=3.4.21.70; Belongs to the peptidase S1 family. Elastase subfamily. Sequence=AAH56210.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc008vja.1 uc008vja.2 uc008vja.3 
ENSMUST00000102524.8 Plcb2 ENSMUST00000102524.8 phospholipase C, beta 2, transcript variant 1 (from RefSeq NM_177568.2) A3KGF7 ENSMUST00000102524.1 ENSMUST00000102524.2 ENSMUST00000102524.3 ENSMUST00000102524.4 ENSMUST00000102524.5 ENSMUST00000102524.6 ENSMUST00000102524.7 NM_177568 PLCB2_MOUSE Plcb2 Q2M4J1 Q3TER8 Q8BI81 uc008lsi.1 uc008lsi.2 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33180; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:43484, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57880, ChEBI:CHEBI:58433; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43485; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Interacts with RAC1. Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=A3KGF7-1; Sequence=Displayed; Name=2; IsoId=A3KGF7-2; Sequence=VSP_026982, VSP_026985, VSP_026986; Name=3; IsoId=A3KGF7-3; Sequence=VSP_026985, VSP_026986; Name=4; IsoId=A3KGF7-4; Sequence=VSP_026981, VSP_026983, VSP_026984; The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16. detection of chemical stimulus involved in sensory perception of bitter taste phosphatidylinositol phospholipase C activity phospholipase C activity calcium ion binding phospholipid binding cytoplasm Golgi apparatus cytosol plasma membrane lipid metabolic process signal transduction phospholipase C-activating G-protein coupled receptor signaling pathway phosphoric diester hydrolase activity lipid catabolic process hydrolase activity G-protein beta/gamma-subunit complex G-protein beta/gamma-subunit complex binding inositol trisphosphate biosynthetic process intracellular signal transduction metal ion binding phosphatidylinositol-mediated signaling sensory perception of bitter taste release of sequestered calcium ion into cytosol uc008lsi.1 uc008lsi.2 
ENSMUST00000102525.11 Arpc3 ENSMUST00000102525.11 actin related protein 2/3 complex, subunit 3 (from RefSeq NM_019824.4) ARPC3_MOUSE ENSMUST00000102525.1 ENSMUST00000102525.10 ENSMUST00000102525.2 ENSMUST00000102525.3 ENSMUST00000102525.4 ENSMUST00000102525.5 ENSMUST00000102525.6 ENSMUST00000102525.7 ENSMUST00000102525.8 ENSMUST00000102525.9 NM_019824 Q3TAT0 Q9JM76 uc008zlf.1 uc008zlf.2 uc008zlf.3 uc008zlf.4 Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Cytoplasm, cytoskeleton Cell projection Nucleus Belongs to the ARPC3 family. actin binding structural constituent of cytoskeleton nucleus cytoplasm cytoskeleton Arp2/3 protein complex lamellipodium regulation of actin filament polymerization cell leading edge filamentous actin Arp2/3 complex-mediated actin nucleation site of double-strand break cell projection actin filament binding cellular response to nerve growth factor stimulus uc008zlf.1 uc008zlf.2 uc008zlf.3 uc008zlf.4 
ENSMUST00000102526.9 Trpv1 ENSMUST00000102526.9 transient receptor potential cation channel, subfamily V, member 1 (from RefSeq NM_001001445.2) ENSMUST00000102526.1 ENSMUST00000102526.2 ENSMUST00000102526.3 ENSMUST00000102526.4 ENSMUST00000102526.5 ENSMUST00000102526.6 ENSMUST00000102526.7 ENSMUST00000102526.8 NM_001001445 Q5SSE1 Q5SSE2 Q5SSE4 Q5WPV5 Q68SW0 Q704Y3 TRPV1_MOUSE uc007kah.1 uc007kah.2 uc007kah.3 uc007kah.4 Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli (PubMed:15194687, PubMed:15489017). Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia (PubMed:10764638). Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). The channel is sensitized by ATP binding. Repeated stimulation with capsaicin gives rise to progressively smaller responses, due to desensitization. This desensitization is triggered by the influx of calcium ions and is inhibited by elevated ATP levels. Ca(2+) and CALM displace ATP from its binding site and trigger a conformation change that leads to a closed, desensitized channel. The double-knot toxin (DkTx) from the Chinese earth tiger tarantula activates the channel and traps it in an open conformation (By similarity). The Scolopendra mutilans RhTx toxin potentiates the heat activation pathway mediated by this channel by binding to the charge- rich outer pore region (in an activated state) (PubMed:26420335). Channel activity is activated via the interaction with PIRT and phosphatidylinositol 4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity. Intracellular PIP2 inhibits desensitization (By similarity). Homotetramer. May also form a heteromeric channel with TRPV3 (By similarity). Interacts with CALM, PRKCM and CSK (By similarity). Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity). Interacts with PIRT (PubMed:18455988). Interacts with the Scolopendra mutilans RhTx toxin (PubMed:26420335). Interacts with TMEM100 (PubMed:25640077). Interacts with PACS2 (By similarity). Q704Y3-1; Q704Y3-1: Trpv1; NbExp=5; IntAct=EBI-15845376, EBI-15845376; Postsynaptic cell membrane ; Multi-pass membrane protein Cell projection, dendritic spine membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha; IsoId=Q704Y3-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q704Y3-2; Sequence=VSP_013430; Detected in neurons in the root ganglia (at protein level). Detected in dorsal root ganglia. The association domain (AD) is necessary for self-association. Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites probably including Ser-117 as a major phosphorylation site. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity. Mice are viable and fertile, but lack behavorial and physiological responses to capsaicin and show impaired responses to noxious heat stimuli. Their dorsal root ganglion neurons do not display calcium channel activation in response to capsaicin or resiniferatoxin. Likewise, their dorsal root ganglion neurons do not display calcium channel activitation in response to low extracellular pH. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily. Sequence=CAI24577.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAI24579.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAI24580.1; Type=Erroneous gene model prediction; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleotide binding temperature homeostasis fever generation microglial cell activation diet induced thermogenesis peptide secretion negative regulation of systemic arterial blood pressure transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity excitatory extracellular ligand-gated ion channel activity cation channel activity calcium channel activity protein binding calmodulin binding ATP binding mitochondrion cytosol plasma membrane integral component of plasma membrane lipid metabolic process ion transport cation transport calcium ion transport inflammatory response positive regulation of cytosolic calcium ion concentration cation transmembrane transporter activity response to pH response to heat external side of plasma membrane response to organonitrogen compound negative regulation of heart rate negative regulation of mitochondrial membrane potential glutamate secretion urinary bladder smooth muscle contraction ligand-gated ion channel activity calcium-release channel activity membrane integral component of membrane chloride channel regulator activity sensory perception of pain cell junction dendrite intrinsic component of plasma membrane dendritic spine membrane ion transmembrane transport cellular response to heat phosphatidylinositol binding identical protein binding cell projection neuron projection neuronal cell body positive regulation of apoptotic process response to peptide hormone synapse postsynaptic membrane positive regulation of nitric oxide biosynthetic process metal ion binding response to pain behavioral response to pain sensory perception of mechanical stimulus thermoception detection of temperature stimulus involved in thermoception detection of temperature stimulus involved in sensory perception of pain detection of chemical stimulus involved in sensory perception of pain release of sequestered calcium ion into cytosol phosphoprotein binding protein homotetramerization transmembrane transport excitatory postsynaptic potential smooth muscle contraction involved in micturition positive regulation of gastric acid secretion calcium ion transmembrane transport cellular response to alkaloid cellular response to ATP cellular response to cytokine stimulus cellular response to tumor necrosis factor cellular response to growth factor stimulus cellular response to acidic pH cellular response to temperature stimulus negative regulation of establishment of blood-brain barrier temperature-gated ion channel activity calcium ion import across plasma membrane response to capsazepine cellular response to nerve growth factor stimulus uc007kah.1 uc007kah.2 uc007kah.3 uc007kah.4 
ENSMUST00000102528.11 Ppp1cc ENSMUST00000102528.11 protein phosphatase 1 catalytic subunit gamma, transcript variant 20 (from RefSeq NR_188783.1) ENSMUST00000102528.1 ENSMUST00000102528.10 ENSMUST00000102528.2 ENSMUST00000102528.3 ENSMUST00000102528.4 ENSMUST00000102528.5 ENSMUST00000102528.6 ENSMUST00000102528.7 ENSMUST00000102528.8 ENSMUST00000102528.9 NR_188783 Ppp1cc Q6ZWM8 Q6ZWM8_MOUSE uc008zks.1 uc008zks.2 uc008zks.3 Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Chromosome, centromere, kinetochore Cleavage furrow Cytoplasm, cytoskeleton, microtubule organizing center Midbody Mitochondrion Nucleus speckle Nucleus, nucleolus Nucleus, nucleoplasm Belongs to the PPP phosphatase family. PP-1 subfamily. protein phosphatase type 1 complex nuclear chromosome, telomeric region phosphoprotein phosphatase activity protein serine/threonine phosphatase activity lamin binding nucleus nucleolus cytoplasm mitochondrion protein dephosphorylation protein C-terminus binding protein phosphatase 1 binding hydrolase activity protein kinase binding protein phosphatase binding protein domain specific binding neuron differentiation macromolecular complex regulation of circadian rhythm dendritic spine macromolecular complex binding metal ion binding protein N-terminus binding positive regulation of glial cell proliferation PTW/PP1 phosphatase complex presynapse postsynapse glutamatergic synapse uc008zks.1 uc008zks.2 uc008zks.3 
ENSMUST00000102532.10 Sema3b ENSMUST00000102532.10 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B, transcript variant 1 (from RefSeq NM_001042779.2) ENSMUST00000102532.1 ENSMUST00000102532.2 ENSMUST00000102532.3 ENSMUST00000102532.4 ENSMUST00000102532.5 ENSMUST00000102532.6 ENSMUST00000102532.7 ENSMUST00000102532.8 ENSMUST00000102532.9 M9MMK0 M9MMK0_MOUSE NM_001042779 Sema3b uc009rmj.1 uc009rmj.2 uc009rmj.3 uc009rmj.4 This gene encodes a secreted protein that belongs to the class 3 semaphorin/collapsin family. Members of this family play a role in growth cone guidance during neurogenesis. The encoded protein inhibits axonal extension. This protein is thought to be an osteoblast protein that regulates bone mass and affects skeletal homeostasis. A similar gene in humans functions as a tumor suppressor gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. Belongs to the semaphorin family. Lacks conserved residue(s) required for the propagation of feature annotation. semaphorin receptor binding uc009rmj.1 uc009rmj.2 uc009rmj.3 uc009rmj.4 
ENSMUST00000102533.11 Tcea3 ENSMUST00000102533.11 transcription elongation factor A (SII), 3 (from RefSeq NM_011542.2) A2AW46 ENSMUST00000102533.1 ENSMUST00000102533.10 ENSMUST00000102533.2 ENSMUST00000102533.3 ENSMUST00000102533.4 ENSMUST00000102533.5 ENSMUST00000102533.6 ENSMUST00000102533.7 ENSMUST00000102533.8 ENSMUST00000102533.9 NM_011542 O88710 P23881 Q9CTZ8 Q9DCZ5 TCEA3_MOUSE Tfiish uc008vhv.1 uc008vhv.2 uc008vhv.3 uc008vhv.4 Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. Nucleus Liver, kidney and heart. Belongs to the TFS-II family. Sequence=BAA28177.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. The sequence from position 1 to 95 is due to a chimeric cDNA.; Evidence=; Sequence=BAB31514.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; nucleic acid binding DNA binding nucleus transcription, DNA-templated regulation of transcription, DNA-templated zinc ion binding metal ion binding uc008vhv.1 uc008vhv.2 uc008vhv.3 uc008vhv.4 
ENSMUST00000102534.11 Rasgrp1 ENSMUST00000102534.11 RAS guanyl releasing protein 1 (from RefSeq NM_011246.3) ENSMUST00000102534.1 ENSMUST00000102534.10 ENSMUST00000102534.2 ENSMUST00000102534.3 ENSMUST00000102534.4 ENSMUST00000102534.5 ENSMUST00000102534.6 ENSMUST00000102534.7 ENSMUST00000102534.8 ENSMUST00000102534.9 GRP1_MOUSE NM_011246 Q3URH0 Q3V401 Q8BQP6 Q9Z1S3 Rasgrp uc033hpk.1 uc033hpk.2 uc033hpk.3 Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (By similarity). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (PubMed:17190838). May also function in differentiation of other cell types. Proto-oncogene, which promotes T- cell lymphomagenesis when its expression is deregulated (PubMed:15829980, PubMed:17210708). Autoinhibited. Activated by diacylglycerol and calcium binding, which induces a conformational change releasing the autoinhibitory state. Regulated by DGKA. Regulated by DGKZ. Regulated by PLC gamma and F-actin polymerization (By similarity). Homodimer. Forms a signaling complex with DGKZ and HRAS. Interacts with F-actin. Interacts with SKAP1 (By similarity). Cytoplasm, cytosol Cell membrane ; Peripheral membrane protein Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane ; Peripheral membrane protein Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin- dependent (By similarity). Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity). Detected in spleen and thymus. Expressed by mature thymocytes and to a lower extent by bone marrow-derived mast cells (at protein level). Detected in B-cells and keratinocytes (at protein level). Up-regulated at the double-negative to double-positive transition during thymocyte development. Down-regulated by 12-O- tetradecanoylphorbol-13-acetate (TPA). The phorbol-ester/DAG-type zinc finger is the principal mediator of the targeting to membranes and is required for functional activation through DAG-binding. Two EF-hand domains are present. However, only EF-hand 1 (and not EF-hand 2) binds calcium. Mice fail to mount anaphylactic allergic reactions and display chronic T-cell immunodeficiencies. Lag (lymphoproliferation-autoimmunity-glomerulonephritis) mice do not express Rasgrp1 and display a systemic lupus erythematosus-like phenotype. Belongs to the RASGRP family. Was reported that thymocytes isolated from a RasGRP1 mutant mouse strain show a defect in Ras activation following T-cell-receptor (TCR) engagement (PubMed:12932358). However, this paper has been retracted because the data in one figure was falsified by one of the authors (PubMed:22808526). The authors stand by the validity of the other figures, results and interpretation in this paper (PubMed:22808526). Furthermore, evidence supporting function is derived by similarity with the human ortholog, so may be true. Golgi membrane phosphatidylserine binding cytokine production positive regulation of protein phosphorylation inflammatory response to antigenic stimulus guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity calcium ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol plasma membrane small GTPase mediated signal transduction zinc ion binding regulation of phosphatidylinositol 3-kinase signaling membrane diacylglycerol binding cell differentiation phosphatidylcholine binding secretory granule localization positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of tumor necrosis factor production positive regulation of natural killer cell activation positive regulation of natural killer cell differentiation positive regulation of T cell differentiation in thymus intracellular signal transduction mast cell granule protein homodimerization activity mast cell degranulation positive regulation of MAP kinase activity positive regulation of GTPase activity positive regulation of natural killer cell mediated cytotoxicity positive regulation of JNK cascade positive regulation of Ras protein signal transduction metal ion binding vesicle transport along microtubule protein oligomerization regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade activation of GTPase activity positive regulation of interferon-gamma secretion uc033hpk.1 uc033hpk.2 uc033hpk.3 
ENSMUST00000102536.11 Rpl11 ENSMUST00000102536.11 ribosomal protein L11 (from RefSeq NM_025919.3) ENSMUST00000102536.1 ENSMUST00000102536.10 ENSMUST00000102536.2 ENSMUST00000102536.3 ENSMUST00000102536.4 ENSMUST00000102536.5 ENSMUST00000102536.6 ENSMUST00000102536.7 ENSMUST00000102536.8 ENSMUST00000102536.9 NM_025919 Q3TPE3 Q6ZWY0 Q9CXW4 RL11_MOUSE uc008vhr.1 uc008vhr.2 uc008vhr.3 Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:36517592). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:36517592). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:36517592). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:36517592). It also couples ribosome biogenesis to p53/TP53 activation (PubMed:21804542). As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:21804542). Promotes nucleolar location of PML (PubMed:15195100). Component of the large ribosomal subunit (LSU) (PubMed:36517592). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11 (By similarity). Interacts with PML (PubMed:15195100). Interacts with MDM2; negatively regulates MDM2- mediated TP53 ubiquitination and degradation (PubMed:15195100, PubMed:21804542). Interacts with NOP53; retains RPL11 into the nucleolus (PubMed:21804542). Q9CXW4; P23804: Mdm2; NbExp=4; IntAct=EBI-1548890, EBI-641788; Nucleus, nucleolus toplasm Belongs to the universal ribosomal protein uL5 family. ribosomal large subunit assembly cytoplasmic translation RNA binding structural constituent of ribosome protein binding nucleus nucleoplasm nucleolus cytoplasm ribosome rRNA processing translation protein targeting 5S rRNA binding positive regulation of gene expression rRNA binding cytosolic large ribosomal subunit cytosolic ribosome ubiquitin protein ligase binding positive regulation of protein binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process macromolecular complex protein localization to nucleus ribosomal large subunit biogenesis polysomal ribosome peroxisome proliferator activated receptor binding negative regulation of sequence-specific DNA binding transcription factor activity synapse protein stabilization regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of ubiquitin protein ligase activity ubiquitin ligase inhibitor activity negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of protein neddylation uc008vhr.1 uc008vhr.2 uc008vhr.3 
ENSMUST00000102541.10 Gale ENSMUST00000102541.10 galactose-4-epimerase, UDP (from RefSeq NM_001356493.1) ENSMUST00000102541.1 ENSMUST00000102541.2 ENSMUST00000102541.3 ENSMUST00000102541.4 ENSMUST00000102541.5 ENSMUST00000102541.6 ENSMUST00000102541.7 ENSMUST00000102541.8 ENSMUST00000102541.9 GALE_MOUSE NM_001356493 Q8R059 uc008vhk.1 uc008vhk.2 uc008vhk.3 Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose; Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914; EC=5.1.3.2; Evidence=; Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D- galactosamine; Xref=Rhea:RHEA:20517, ChEBI:CHEBI:57705, ChEBI:CHEBI:67138; EC=5.1.3.7; Evidence=; Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence=; Carbohydrate metabolism; galactose metabolism. Homodimer. Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-N-acetylglucosamine 4-epimerase activity UDP-glucose 4-epimerase activity cytosol carbohydrate metabolic process galactose metabolic process isomerase activity galactose catabolic process galactose catabolic process via UDP-galactose identical protein binding protein homodimerization activity glycolytic process from galactose uc008vhk.1 uc008vhk.2 uc008vhk.3 
ENSMUST00000102542.10 Dph6 ENSMUST00000102542.10 diphthamine biosynthesis 6, transcript variant 2 (from RefSeq NM_025675.5) Atpbd4 DPH6_MOUSE ENSMUST00000102542.1 ENSMUST00000102542.2 ENSMUST00000102542.3 ENSMUST00000102542.4 ENSMUST00000102542.5 ENSMUST00000102542.6 ENSMUST00000102542.7 ENSMUST00000102542.8 ENSMUST00000102542.9 NM_025675 Q3UL00 Q8R1W5 Q9CQ28 uc008lqk.1 uc008lqk.2 uc008lqk.3 Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor 2 (EEF2) to diphthamide (By similarity). Reaction=ATP + diphthine-[translation elongation factor 2] + NH4(+) = AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+); Xref=Rhea:RHEA:19753, Rhea:RHEA-COMP:10172, Rhea:RHEA- COMP:10174, ChEBI:CHEBI:15378, ChEBI:CHEBI:16692, ChEBI:CHEBI:28938, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:82696, ChEBI:CHEBI:456215; EC=6.3.1.14; Protein modification; peptidyl-diphthamide biosynthesis. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9CQ28-1; Sequence=Displayed; Name=2; IsoId=Q9CQ28-2; Sequence=VSP_024125; Name=3; IsoId=Q9CQ28-3; Sequence=VSP_024126; Belongs to the Diphthine--ammonia ligase family. nucleotide binding ATP binding nucleus nucleolus ligase activity diphthine-ammonia ligase activity peptidyl-diphthamide biosynthetic process from peptidyl-histidine uc008lqk.1 uc008lqk.2 uc008lqk.3 
ENSMUST00000102546.4 Il22ra1 ENSMUST00000102546.4 interleukin 22 receptor, alpha 1 (from RefSeq NM_178257.2) B2RU51 ENSMUST00000102546.1 ENSMUST00000102546.2 ENSMUST00000102546.3 I22R1_MOUSE NM_178257 Q3URP9 Q80XZ4 uc008vgx.1 uc008vgx.2 uc008vgx.3 uc008vgx.4 Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. Heterodimer with IL10RB and with IL20RB. Cell membrane ; Single-pass type I membrane protein Expressed in kidney, liver and lung. By LPS stimulation in the liver. Phosphorylated by GSK3-BETA and MAPK; phosphorylation by GSK3-BETA stabilizes IL22RA1 by preventing its proteasomal degradation. Belongs to the type II cytokine receptor family. cytokine receptor activity plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway interleukin-20 binding defense response to Gram-negative bacterium uc008vgx.1 uc008vgx.2 uc008vgx.3 uc008vgx.4 
ENSMUST00000102549.10 Nipal3 ENSMUST00000102549.10 NIPA-like domain containing 3, transcript variant 2 (from RefSeq NM_028995.4) ENSMUST00000102549.1 ENSMUST00000102549.2 ENSMUST00000102549.3 ENSMUST00000102549.4 ENSMUST00000102549.5 ENSMUST00000102549.6 ENSMUST00000102549.7 ENSMUST00000102549.8 ENSMUST00000102549.9 NM_028995 NPAL3_MOUSE Npal3 Q6PG85 Q8BGN5 Q9D2Y2 uc008vgo.1 uc008vgo.2 uc008vgo.3 Membrane ; Multi-pass membrane protein Belongs to the NIPA family. Sequence=BAB31323.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; immunoglobulin production magnesium ion transmembrane transporter activity magnesium ion transport membrane integral component of membrane magnesium ion transmembrane transport uc008vgo.1 uc008vgo.2 uc008vgo.3 
ENSMUST00000102553.11 Hmgn2 ENSMUST00000102553.11 high mobility group nucleosomal binding domain 2 (from RefSeq NM_016957.3) ENSMUST00000102553.1 ENSMUST00000102553.10 ENSMUST00000102553.2 ENSMUST00000102553.3 ENSMUST00000102553.4 ENSMUST00000102553.5 ENSMUST00000102553.6 ENSMUST00000102553.7 ENSMUST00000102553.8 ENSMUST00000102553.9 Hmgn2 NM_016957 Q5BL14 Q5BL14_MOUSE uc008vdq.1 uc008vdq.2 uc008vdq.3 Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Nucleus Belongs to the HMGN family. chromatin nucleus nucleosomal DNA binding uc008vdq.1 uc008vdq.2 uc008vdq.3 
ENSMUST00000102554.8 Kif1c ENSMUST00000102554.8 kinesin family member 1C (from RefSeq NM_153103.2) ENSMUST00000102554.1 ENSMUST00000102554.2 ENSMUST00000102554.3 ENSMUST00000102554.4 ENSMUST00000102554.5 ENSMUST00000102554.6 ENSMUST00000102554.7 KIF1C_MOUSE NM_153103 O35071 Q5SX62 uc287zst.1 uc287zst.2 Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility (By similarity). Monomer. Cytoplasm, cytoskeleton Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. nucleotide binding microtubule motor activity ATP binding cytoplasm Golgi apparatus cytoskeleton kinesin complex microtubule retrograde vesicle-mediated transport, Golgi to ER microtubule-based movement microtubule binding ATP-dependent microtubule motor activity, plus-end-directed vesicle-mediated transport ATPase activity axon dendrite cytoskeleton-dependent intracellular transport neuron projection axon cytoplasm anterograde neuronal dense core vesicle transport retrograde neuronal dense core vesicle transport uc287zst.1 uc287zst.2 
ENSMUST00000102555.11 Dnajc24 ENSMUST00000102555.11 DnaJ heat shock protein family (Hsp40) member C24, transcript variant 1 (from RefSeq NM_026992.3) DJC24_MOUSE Dph4 ENSMUST00000102555.1 ENSMUST00000102555.10 ENSMUST00000102555.2 ENSMUST00000102555.3 ENSMUST00000102555.4 ENSMUST00000102555.5 ENSMUST00000102555.6 ENSMUST00000102555.7 ENSMUST00000102555.8 ENSMUST00000102555.9 NM_026992 Q91ZF0 Q9D9S7 Zcsl3 uc008llf.1 uc008llf.2 uc008llf.3 uc008llf.4 The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2). Protein modification; peptidyl-diphthamide biosynthesis. Monomer and homooligomer. Iron binding promotes oligomerization (By similarity). Cytoplasm, cytoskeleton Detected in heart, brain, spleen, lung, liver, kidney and testis. The DPH-type metal-binding (MB) domain can bind either zinc or iron ions. High embryonic lethality at 14.5 dpc. As early as 10.5 dpc, embryos are smaller than their wild-type littermates. Embryos that survive long enough to initiate digit formation show one or more additional preaxial digits. Belongs to the DPH4 family. Sequence=AAK21968.1; Type=Miscellaneous discrepancy; Note=A nucleotide mismatch versus the mouse genome results in the formation of an upstream ATG start codon.; Evidence=; ATPase activator activity cytoplasm cytoskeleton ferrous iron binding zinc ion binding peptidyl-diphthamide biosynthetic process from peptidyl-histidine positive regulation of ATPase activity metal ion binding oxidation-reduction process uc008llf.1 uc008llf.2 uc008llf.3 uc008llf.4 
ENSMUST00000102556.10 Chrne ENSMUST00000102556.10 cholinergic receptor, nicotinic, epsilon polypeptide (from RefSeq NM_009603.1) ACHE_MOUSE Acre ENSMUST00000102556.1 ENSMUST00000102556.2 ENSMUST00000102556.3 ENSMUST00000102556.4 ENSMUST00000102556.5 ENSMUST00000102556.6 ENSMUST00000102556.7 ENSMUST00000102556.8 ENSMUST00000102556.9 NM_009603 P20782 uc007jvo.1 uc007jvo.2 This gene encodes the epsilon subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. In mice, deficiency of this gene can lead to a decline in the number of nicotinic acetylcholine receptors at neuromuscular junctions and causes progressive muscle weakness, atrophy and premature death. Mutations in this gene serve as a pathophysiological model for human congenital myasthenia. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Nov 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X55718.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (By similarity). Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub- subfamily. skeletal muscle contraction transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane integral component of plasma membrane acetylcholine-gated channel complex ion transport cation transport signal transduction chemical synaptic transmission synaptic transmission, cholinergic neuromuscular synaptic transmission membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction neuromuscular junction ion transmembrane transport response to nicotine regulation of membrane potential neuron projection synapse postsynaptic membrane neurological system process regulation of postsynaptic membrane potential excitatory postsynaptic potential integral component of postsynaptic specialization membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential acetylcholine receptor activity acetylcholine binding uc007jvo.1 uc007jvo.2 
ENSMUST00000102561.11 Rpa2 ENSMUST00000102561.11 replication protein A2 (from RefSeq NM_011284.3) ENSMUST00000102561.1 ENSMUST00000102561.10 ENSMUST00000102561.2 ENSMUST00000102561.3 ENSMUST00000102561.4 ENSMUST00000102561.5 ENSMUST00000102561.6 ENSMUST00000102561.7 ENSMUST00000102561.8 ENSMUST00000102561.9 NM_011284 Q3TE40 Q62193 RFA2_MOUSE Rpa2 Rpa34 uc008vbu.1 uc008vbu.2 uc008vbu.3 As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Component of the replication protein A complex (RPA/RP-A), a heterotrimeric complex composed of RPA1, RPA2 and RPA3. Interacts with PRPF19; the PRP19-CDC5L complex is recruited to the sites of DNA repair where it ubiquitinates the replication protein A complex (RPA) (By similarity). Interacts with SERTAD3. Interacts with TIPIN (PubMed:17141802). Interacts with TIMELESS (PubMed:17141802). Interacts with PPP4R2; the interaction is direct, DNA damage-dependent and mediates the recruitment of the PP4 catalytic subunit PPP4C (By similarity). Interacts (hyperphosphorylated) with RAD51 (By similarity). Interacts with SMARCAL1; the interaction is direct and mediates the recruitment to the RPA complex of SMARCAL1 (By similarity). Interacts with RAD52 and XPA; those interactions are direct and associate RAD52 and XPA to the RPA complex (By similarity). Interacts with FBH1 (By similarity). Interacts with ETAA1; the interaction is direct and promotes ETAA1 recruitment at stalled replication forks (By similarity). Interacts with DDI2 (By similarity). Interacts (in unphosphorylated form via N-terminus) with EIF4EBP3; the interaction enhances EIF4EBP3-mediated inhibition of EIF4E-mediated mRNA nuclear export (By similarity). Nucleus Nucleus, PML body Note=Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. Differentially phosphorylated throughout the cell cycle, becoming phosphorylated at the G1-S transition and dephosphorylated in late mitosis. Mainly phosphorylated at Ser-23 and Ser-29, by cyclin A-CDK2 and cyclin B-CDK1, respectively during DNA replication and mitosis. Dephosphorylation may require the serine/threonine-protein phosphatase 4. Phosphorylation at Ser-23 and Ser-29 is a prerequisite for further phosphorylation. Becomes hyperphosphorylated on additional residues including Ser-4, Ser-8, Thr-21 and Ser-33 in response to DNA damage. Hyperphosphorylation is mediated by ATM, ATR and PRKDC. Primarily recruited to DNA repair nuclear foci as a hypophosphorylated form it undergoes subsequent hyperphosphorylation, catalyzed by ATR. Hyperphosphorylation is required for RAD51 recruitment to chromatin and efficient DNA repair. Phosphorylation at Thr-21 depends upon RFWD3 presence. DNA damage-induced 'Lys-63'-linked polyubiquitination by PRPF19 mediates ATRIP recruitment to the RPA complex at sites of DNA damage and activation of ATR. Ubiquitinated by RFWD3 at stalled replication forks in response to DNA damage: ubiquitination by RFWD3 does not lead to degradation by the proteasome and promotes removal of the RPA complex from stalled replication forks, promoting homologous recombination. Belongs to the replication factor A protein 2 family. telomere maintenance double-strand break repair via homologous recombination chromosome, telomeric region chromatin DNA binding damaged DNA binding single-stranded DNA binding protein binding nucleus nucleoplasm DNA replication factor A complex DNA replication DNA repair base-excision repair nucleotide-excision repair mismatch repair DNA recombination cellular response to DNA damage stimulus regulation of double-strand break repair via homologous recombination nuclear body PML body enzyme binding protein phosphatase binding mitotic G1 DNA damage checkpoint ubiquitin protein ligase binding protein localization to chromosome site of double-strand break protein N-terminus binding G-rich strand telomeric DNA binding regulation of DNA damage checkpoint uc008vbu.1 uc008vbu.2 uc008vbu.3 
ENSMUST00000102564.11 Arrb2 ENSMUST00000102564.11 arrestin, beta 2, transcript variant 3 (from RefSeq NM_145429.5) ARRB2_MOUSE ENSMUST00000102564.1 ENSMUST00000102564.10 ENSMUST00000102564.2 ENSMUST00000102564.3 ENSMUST00000102564.4 ENSMUST00000102564.5 ENSMUST00000102564.6 ENSMUST00000102564.7 ENSMUST00000102564.8 ENSMUST00000102564.9 NM_145429 Q3TCM2 Q5F2D8 Q5F2E0 Q91YI4 uc007jur.1 uc007jur.2 uc007jur.3 uc007jur.4 Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin- mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta- arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as a signaling scaffold for the AKT1 pathway. GPCRs for which the beta- arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta- arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa- B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in IL8-mediated granule release in neutrophils (By similarity). Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires GRK2. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF- kappa-B and JUN. Involved in insulin resistance by acting as insulin- induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in the internalization of the atypical chemokine receptor ACKR3 (By similarity). Acts as an adapter protein coupling FFAR4 receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis. During the activation step of NLRP3 inflammasome, directly associates with NLRP3 leading to inhibition of pro-inflammatory cytokine release and inhibition of inflammation. Homooligomer; the self-association is mediated by InsP6- binding (Probable). Heterooligomer with ARRB1; the association is mediated by InsP6-binding. Interacts with ADRB2 and CHRM2. Interacts with PDE4A. Interacts with PDE4D. Interacts with MAPK10, MAPK1 and MAPK3. Interacts with DRD2. Interacts with FSHR. Interacts with CLTC. Interacts with HTR2C. Interacts with CCR5. Interacts with CXCR4. Interacts with SRC. Interacts with DUSP16; the interaction is interrupted by stimulation of AGTR1 and activation of MAPK10. Interacts with CHUK; the interaction is enhanced stimulation of ADRB2. Interacts with RELA. Interacts with MDM2; the interaction is enhanced by activation of GPCRs. Interacts with SLC9A5. Interacts with TRAF6. Interacts with IGF1R. Interacts with ENG. Interacts with ARRB2. Interacts with KIR2DL1, KIR2DL3 and KIR2DL4. Interacts with LDLR. Interacts with AP2B1. Interacts with C5AR1. Interacts with RAF1. Interacts with MAP2K1. Interacts with MAPK1. Interacts with MAPK10; the interaction enhances MAPK10 activation by MAP3K5. Interacts with MAP2K4; the interaction is enhanced by presence of MAP3K5 and MAPK10. Interacts with MAP3K5. Interacts with AKT1. Interacts with IKBKB and MAP3K14. Interacts with SMO (activated). Interacts with GSK3A and GSK3B. Interacts with CXCR4; the interaction is dependent on C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with GPR143. Interacts with HCK and CXCR1 (phosphorylated) (By similarity). Associates with protein phosphatase 2A (PP2A). Interacts with ACKR3 and ACKR4 (By similarity). Interacts with ARRDC1; the interaction is direct (By similarity). Interacts with GPR61, GPR62 and GPR135 (By similarity). Interacts (via NACHT and LRR domains) with NLRP3; this interaction is direct and inducible by omega-3 polyunsaturated fatty acids (PUFAs) (By similarity). Interacts with FFAR4 (via C-terminus); this interaction is stimulated by long-chain fatty acids (LCFAs) (PubMed:26873857). Interacts with GPR35 (By similarity). Interacts with GPR84 (By similarity). Q91YI4; P58660: Card10; NbExp=7; IntAct=EBI-994161, EBI-8344379; Q91YI4; Q7TMA4: Ffar4; NbExp=4; IntAct=EBI-994161, EBI-2912413; Cytoplasm Nucleus Cell membrane Membrane, clathrin-coated pit Cytoplasmic vesicle Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91YI4-1; Sequence=Displayed; Name=2; IsoId=Q91YI4-2; Sequence=VSP_020652; Predominantly localized in neuronal tissues and in the spleen. Phosphorylated at Thr-383 in the cytoplasm; probably dephosphorylated at the plasma membrane. The phosphorylation does not regulate internalization and recycling of ADRB2, interaction with clathrin or AP2B1 (By similarity). The ubiquitination status appears to regulate the formation and trafficking of beta-arrestin-GPCR complexes and signaling. Ubiquitination appears to occur GPCR-specific. Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2. Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex. Stimulation of a class A GPCR, such as ADRB2, induces transient ubiquitination and subsequently promotes association with USP33. Stimulation of a class B GPCR promotes a sustained ubiquitination. Deubiquitinated by USP20; allowing USP20 to deubiquitinate TRAF6 leading to inhibition of NF-kappa-B signaling (By similarity). Hydroxylation by PHD2 modulates the rate of internalization by slowing down recruitment to the plasma membrane and inhibiting subsequent co-internalization with class A receptors. Loss of beta-2 adrenergic receptor/ADRB2 ubiquitination. Reduction of dopamine-dependent behaviors, loss of Akt1 regulation by dopamine in the striatum and disruption of the dopamine- dependent interaction of Akt1 with its negative regulator, protein phosphatase 2A. Increased serum LDL-cholesterol levels upon high fat diet. Exacerbates insulin resistance. Elevated cytotoxicity of natural killer cells and lowered susceptibility to mouse cytomegalovirus infection. Belongs to the arrestin family. G-protein coupled receptor binding regulation of protein phosphorylation negative regulation of protein phosphorylation positive regulation of protein phosphorylation G-protein coupled receptor internalization desensitization of G-protein coupled receptor protein signaling pathway by arrestin positive regulation of receptor internalization receptor binding protein binding nucleus cytoplasm endosome cytosol plasma membrane clathrin-coated pit transcription from RNA polymerase II promoter endocytosis signal transduction transforming growth factor beta receptor signaling pathway G-protein coupled receptor signaling pathway brain development adult walking behavior regulation of G-protein coupled receptor protein signaling pathway negative regulation of signal transduction positive regulation of gene expression postsynaptic density protein transport membrane basolateral plasma membrane protein ubiquitination enzyme binding protein domain specific binding endocytic vesicle negative regulation of protein ubiquitination positive regulation of protein ubiquitination cytoplasmic vesicle receptor internalization ubiquitin protein ligase binding alpha-1A adrenergic receptor binding alpha-1B adrenergic receptor binding angiotensin receptor binding type 1 angiotensin receptor binding D1 dopamine receptor binding follicle-stimulating hormone receptor binding type 2A serotonin receptor binding platelet activating factor receptor binding negative regulation of NF-kappaB transcription factor activity positive regulation of synaptic transmission, dopaminergic negative regulation of interleukin-1 beta production negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of collagen biosynthetic process positive regulation of peptidyl-serine phosphorylation negative regulation of toll-like receptor signaling pathway negative regulation of GTPase activity negative regulation of smooth muscle cell apoptotic process follicle-stimulating hormone signaling pathway identical protein binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process dendritic spine intracellular membrane-bounded organelle protein kinase B binding negative regulation of neuron apoptotic process macromolecular complex binding postsynaptic membrane positive regulation of protein kinase activity negative regulation of natural killer cell mediated cytotoxicity positive regulation of peptidyl-tyrosine phosphorylation detection of temperature stimulus involved in sensory perception of pain mitogen-activated protein kinase binding positive regulation of protein kinase B signaling positive regulation of calcium ion transport binding, bridging cell chemotaxis regulation of androgen receptor signaling pathway positive regulation of ERK1 and ERK2 cascade 14-3-3 protein binding negative regulation of release of cytochrome c from mitochondria positive regulation of epithelial cell apoptotic process arrestin family protein binding positive regulation of DNA biosynthetic process positive regulation of cardiac muscle cell differentiation uc007jur.1 uc007jur.2 uc007jur.3 uc007jur.4 
ENSMUST00000102565.4 Fbxo3 ENSMUST00000102565.4 F-box protein 3, transcript variant 2 (from RefSeq NM_020593.2) A2BHN5 A2BHN7 ENSMUST00000102565.1 ENSMUST00000102565.2 ENSMUST00000102565.3 FBX3_MOUSE Fba Fbx3 NM_020593 Q3TKB0 Q3U9C1 Q8C7I0 Q8CEJ0 Q91VI9 Q9D2J5 Q9DC63 Q9JIE4 uc008lji.1 uc008lji.2 uc008lji.3 Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome (By similarity). In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented (By similarity). PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2: specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (PubMed:23542741). Protein modification; protein ubiquitination. Part of a SCF (SKP1-cullin-F-box) protein ligase complex SCF(FBXO3) consisting of FBXO3, SKP1, CUL1 and RBX1. Interacts with PML, interaction is direct and takes place either alone or within the SCF complex. Nucleus Note=Colocalizes with PML at the peripheries of nuclear bodies. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DC63-1; Sequence=Displayed; Name=2; IsoId=Q9DC63-2; Sequence=VSP_039616, VSP_039617; Name=3; IsoId=Q9DC63-3; Sequence=VSP_039615, VSP_039616, VSP_039617; nucleus nucleoplasm cytosol uc008lji.1 uc008lji.2 uc008lji.3 
ENSMUST00000102567.4 Med18 ENSMUST00000102567.4 mediator complex subunit 18 (from RefSeq NM_026039.3) ENSMUST00000102567.1 ENSMUST00000102567.2 ENSMUST00000102567.3 MED18_MOUSE NM_026039 Q9CZ82 uc008vbi.1 uc008vbi.2 uc008vbi.3 uc008vbi.4 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Nucleus Belongs to the Mediator complex subunit 18 family. ubiquitin ligase complex transcription cofactor activity nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter termination of RNA polymerase II transcription protein ubiquitination mediator complex core mediator complex ubiquitin protein ligase activity uc008vbi.1 uc008vbi.2 uc008vbi.3 uc008vbi.4 
ENSMUST00000102568.10 Phactr4 ENSMUST00000102568.10 phosphatase and actin regulator 4, transcript variant 1 (from RefSeq NM_175306.5) A2ALF7 A2ALG0 ENSMUST00000102568.1 ENSMUST00000102568.2 ENSMUST00000102568.3 ENSMUST00000102568.4 ENSMUST00000102568.5 ENSMUST00000102568.6 ENSMUST00000102568.7 ENSMUST00000102568.8 ENSMUST00000102568.9 F6QNZ3 Kiaa4120 NM_175306 PHAR4_MOUSE Q501J7 Q5DTM4 Q6DI97 Q8C7U9 uc008vbg.1 uc008vbg.2 uc008vbg.3 uc008vbg.4 uc008vbg.5 uc008vbg.6 Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway. Binds PPP1CA and actin. Cytoplasm. Cell projection, lamellipodium. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q501J7-1; Sequence=Displayed; Name=2; IsoId=Q501J7-2; Sequence=VSP_025440; Name=3; IsoId=Q501J7-3; Sequence=VSP_025439; During embryonic development, most strongly expressed in neural tissue. Expressed in a dynamic pattern during neurulation: from 8.5 dpc to 9.5 dpc, the period of cranial neural closure and spatially regulated proliferation, it is expressed strongly in the ventral region of the cranial neural tube. By 10.5 dpc, expressed more uniformly along the dorsal and ventral aspects of the cranial neural tube. Also expressed in the neural retina and lens. Neural tube and eye defects in embryos followed by death. By 9.25 dpc, mutant embryos show failure to close the cranial neural tube. About 15% of homozygous mutant embryos exhibit severe exencephaly, along with a wavy spinal neural tube and a shortened anterior/posterior body axis, and die around 10.5 dpc. Remaining embryos exhibit complete exencephaly from the forebrain to hindbrain. Most embryos die by 14.5 dpc, but a few survive to birth and die shortly thereafter. Embryos also have eye defects: they display overgrowth of the neural retina and retinal pigment epithelium. Embryos also display coloboma at 12.5 dpc and 16.5 dpc, due to defects in closure of optic fissure. Defects are due to elevated proliferation and abnormally phosphorylated, inactive PP1, resulting in RB1 hyperphosphorylation, derepression of E2F targets, and abnormal cell- cycle progression. Embryos also show embryonic gastrointestinal defects due to colon hypoganglionosis, which resembles human Hirschsprung disease: ENCCs within the embryonic gut display a collective cell migration defect and show undirected cellular protrusions and disrupted directional and chain migration. Belongs to the phosphatase and actin regulator family. Sequence=BAD90294.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAM26520.1; Type=Erroneous gene model prediction; Evidence=; neural crest cell migration neural tube closure actin binding protein phosphatase inhibitor activity cytoplasm Rho protein signal transduction multicellular organism development nervous system development protein phosphatase 1 binding protein phosphatase regulator activity lamellipodium actin cytoskeleton organization negative regulation of phosphoprotein phosphatase activity cell projection positive regulation of catalytic activity regulation of phosphoprotein phosphatase activity enteric nervous system development regulation of cell cycle closure of optic fissure protein phosphatase activator activity negative regulation of integrin-mediated signaling pathway uc008vbg.1 uc008vbg.2 uc008vbg.3 uc008vbg.4 uc008vbg.5 uc008vbg.6 
ENSMUST00000102572.8 Asgr2 ENSMUST00000102572.8 asialoglycoprotein receptor 2, transcript variant 2 (from RefSeq NM_007493.3) ASGR2_MOUSE Asgr-2 ENSMUST00000102572.1 ENSMUST00000102572.2 ENSMUST00000102572.3 ENSMUST00000102572.4 ENSMUST00000102572.5 ENSMUST00000102572.6 ENSMUST00000102572.7 NM_007493 P24721 uc007jtt.1 uc007jtt.2 uc007jtt.3 This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Sep 2015]. Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. Interacts with LASS2. Membrane; Single-pass type II membrane protein. Expressed exclusively in hepatic parenchymal cells. Calcium is required for ligand binding. Name=Functional Glycomics Gateway - Glycan Binding; Note=Hepatic asialoglycoprotein receptor subunit 2; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_159"; endocytosis glycoprotein metabolic process membrane integral component of membrane carbohydrate binding bone mineralization regulation of protein stability endoplasmic reticulum quality control compartment perinuclear region of cytoplasm lipid homeostasis uc007jtt.1 uc007jtt.2 uc007jtt.3 
ENSMUST00000102573.8 Trim44 ENSMUST00000102573.8 tripartite motif-containing 44 (from RefSeq NM_020267.3) ENSMUST00000102573.1 ENSMUST00000102573.2 ENSMUST00000102573.3 ENSMUST00000102573.4 ENSMUST00000102573.5 ENSMUST00000102573.6 ENSMUST00000102573.7 NM_020267 Q4KMS1 Q4KMS1_MOUSE Trim44 uc008lhv.1 uc008lhv.2 Interacts (via coiled coil) with TRIM17 (via coiled coil). positive regulation of cytokine-mediated signaling pathway positive regulation of defense response to virus by host zinc ion binding regulation of gene expression positive regulation of transcription, DNA-templated protein stabilization positive regulation of NIK/NF-kappaB signaling uc008lhv.1 uc008lhv.2 
ENSMUST00000102574.10 Acadvl ENSMUST00000102574.10 acyl-Coenzyme A dehydrogenase, very long chain (from RefSeq NM_017366.3) ACADV_MOUSE Acadvl ENSMUST00000102574.1 ENSMUST00000102574.2 ENSMUST00000102574.3 ENSMUST00000102574.4 ENSMUST00000102574.5 ENSMUST00000102574.6 ENSMUST00000102574.7 ENSMUST00000102574.8 ENSMUST00000102574.9 NM_017366 O35289 O55133 P50544 Vlcad uc007jto.1 uc007jto.2 uc007jto.3 uc007jto.4 This gene encodes a homodimeric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C16- and C20-acylCoA and localizes to the inner mitochondrial membrane (unlike related acyl-CoA dehydrogenases). In mice, deficiency of this gene can cause ventricular arrhythmias as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]. Sequence Note: The transit peptide annotated at aa 1-41 is inferred by similarity to the cleavage site in the orthologous rat protein as described in PMID: 8034667. The software program TargetP1.1 predicts that the transit peptide in mouse is aa 1-27. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026559.1, AK076037.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains. Reaction=a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)- enoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:19181, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:83724, ChEBI:CHEBI:83728; EC=1.3.8.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19182; Evidence=; Reaction=dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47296, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57330, ChEBI:CHEBI:57375, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47297; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:47316, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57385, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:61405; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47317; Evidence=; Reaction=H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:43448, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57379, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:61526; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43449; Evidence=; Reaction=H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47240, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57394, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:71412; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47241; Evidence=; Reaction=eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47236, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57380, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:74691; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47237; Evidence=; Reaction=docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:47228, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:65059, ChEBI:CHEBI:74692; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47229; Evidence=; Reaction=H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:47232, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:65052, ChEBI:CHEBI:74693; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47233; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Lipid metabolism; mitochondrial fatty acid beta-oxidation. Homodimer. Homodimerizes after import into the mitochondrion. Mitochondrion inner membrane ; Peripheral membrane protein S-nitrosylation at Cys-238 in liver improves catalytic efficiency. Belongs to the acyl-CoA dehydrogenase family. fatty-acyl-CoA binding temperature homeostasis acyl-CoA dehydrogenase activity long-chain-acyl-CoA dehydrogenase activity nucleus nucleolus mitochondrion mitochondrial inner membrane cytosol lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation fatty acid catabolic process response to cold membrane oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors very-long-chain-acyl-CoA dehydrogenase activity epithelial cell differentiation mitochondrial membrane fatty acid beta-oxidation using acyl-CoA dehydrogenase mitochondrial nucleoid negative regulation of fatty acid biosynthetic process negative regulation of fatty acid oxidation flavin adenine dinucleotide binding oxidation-reduction process regulation of cholesterol metabolic process uc007jto.1 uc007jto.2 uc007jto.3 uc007jto.4 
ENSMUST00000102576.4 Matn1 ENSMUST00000102576.4 matrilin 1, cartilage matrix protein (from RefSeq NM_010769.2) Cmp Crtm ENSMUST00000102576.1 ENSMUST00000102576.2 ENSMUST00000102576.3 MATN1_MOUSE NM_010769 P51942 Q80VN5 uc008uzx.1 uc008uzx.2 uc008uzx.3 uc008uzx.4 Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen. Homotrimer. Interacts with COMP (By similarity). Secreted, extracellular space, extracellular matrix chondrocyte differentiation growth plate cartilage chondrocyte morphogenesis extracellular matrix structural constituent calcium ion binding protein binding extracellular region extracellular space regulation of bone mineralization extracellular matrix uc008uzx.1 uc008uzx.2 uc008uzx.3 uc008uzx.4 
ENSMUST00000102578.11 Ankrd13a ENSMUST00000102578.11 ankyrin repeat domain 13a, transcript variant 1 (from RefSeq NM_026718.2) AN13A_MOUSE Ankrd13 ENSMUST00000102578.1 ENSMUST00000102578.10 ENSMUST00000102578.2 ENSMUST00000102578.3 ENSMUST00000102578.4 ENSMUST00000102578.5 ENSMUST00000102578.6 ENSMUST00000102578.7 ENSMUST00000102578.8 ENSMUST00000102578.9 NM_026718 Q2VPQ7 Q6P7F2 Q80UP5 uc008zaf.1 uc008zaf.2 uc008zaf.3 uc008zaf.4 Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). Interacts (via the UIM 3 and 4 repeats) with EGFR (ubiquitinated); the interaction is direct, inhibited by ANKRD13A monoubiquitination and may regulate EGFR internalization. Cell membrane. Late endosome. Note=Interaction with EGFR may enhance association with the cell membrane. The UIM repeats 3 and 4 are required for binding to ubiquitinated EGFR and 'Lys-63'-linked ubiquitin. Monoubiquitinated, inhibits interaction with ubiquitinated EGFR. Sequence=AAH49187.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of receptor internalization cytoplasm endosome late endosome plasma membrane membrane perinuclear region of cytoplasm negative regulation of protein localization to endosome uc008zaf.1 uc008zaf.2 uc008zaf.3 uc008zaf.4 
ENSMUST00000102580.10 2810408A11Rik ENSMUST00000102580.10 RIKEN cDNA 2810408A11 gene, transcript variant 1 (from RefSeq NM_027419.4) 2810408A11Rik ENSMUST00000102580.1 ENSMUST00000102580.2 ENSMUST00000102580.3 ENSMUST00000102580.4 ENSMUST00000102580.5 ENSMUST00000102580.6 ENSMUST00000102580.7 ENSMUST00000102580.8 ENSMUST00000102580.9 NM_027419 Q6NSU2 Q6NSU2_MOUSE uc007jsj.1 uc007jsj.2 uc007jsj.3 Belongs to the protein phosphatase inhibitor 2 family. protein phosphatase inhibitor activity regulation of signal transduction negative regulation of phosphoprotein phosphatase activity regulation of phosphoprotein phosphatase activity uc007jsj.1 uc007jsj.2 uc007jsj.3 
ENSMUST00000102581.11 Kctd10 ENSMUST00000102581.11 potassium channel tetramerisation domain containing 10, transcript variant 2 (from RefSeq NM_026145.4) BACD3_MOUSE ENSMUST00000102581.1 ENSMUST00000102581.10 ENSMUST00000102581.2 ENSMUST00000102581.3 ENSMUST00000102581.4 ENSMUST00000102581.5 ENSMUST00000102581.6 ENSMUST00000102581.7 ENSMUST00000102581.8 ENSMUST00000102581.9 NM_026145 Q922M3 uc008yzm.1 uc008yzm.2 uc008yzm.3 uc008yzm.4 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity). Protein modification; protein ubiquitination. Homotetramer; forms a two-fold symmetric tetramer in solution. Interacts with CUL3; interaction is direct and forms a 5:5 heterodecamer (By similarity). Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1 (By similarity). Interacts with DNA polymerase delta subunit 2/POLD2 (By similarity). Interacts with PCNA (By similarity). Associated with the tectonic-like complex (also named B9 complex); however as Kctd10 has not been identified in all tectonic-like complexes purifications it is unclear whether it is really part of the complex (PubMed:22179047). Nucleus Belongs to the BACURD family. angiogenesis Notch binding protein binding nucleus nucleoplasm cytosol ubiquitin-dependent protein catabolic process heart development protein ubiquitination GTP-Rho binding Cul3-RING ubiquitin ligase complex negative regulation of Rho protein signal transduction MKS complex proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of Notch signaling pathway protein homooligomerization ubiquitin-protein transferase activity uc008yzm.1 uc008yzm.2 uc008yzm.3 uc008yzm.4 
ENSMUST00000102582.8 Acacb ENSMUST00000102582.8 acetyl-Coenzyme A carboxylase beta, transcript variant 2 (from RefSeq NM_133904.3) ACACB_MOUSE Acacb Acc2 Accb E9Q4Z2 ENSMUST00000102582.1 ENSMUST00000102582.2 ENSMUST00000102582.3 ENSMUST00000102582.4 ENSMUST00000102582.5 ENSMUST00000102582.6 ENSMUST00000102582.7 NM_133904 Q6JIZ0 uc008yzi.1 uc008yzi.2 uc008yzi.3 uc008yzi.4 Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (By similarity). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (By similarity). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (PubMed:24913514). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (PubMed:24913514). Reaction=acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl- CoA + phosphate; Xref=Rhea:RHEA:11308, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:456216; EC=6.4.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11309; Evidence=; Name=biotin; Xref=ChEBI:CHEBI:57586; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= Note=Binds 2 magnesium or manganese ions per subunit. Activity is increased by oligomerization of the protein into filaments that correspond to the most active form of the carboxylase. The oligomerization and the activity of the enzyme are inhibited by phosphorylation at Ser-212 (PubMed:24913514). Inhibited by its own product malonyl-CoA. Activation by MID1IP1 is citrate dependent. Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Monomer, homodimer, and homotetramer. Forms filamentous polymers. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity in a citrate-dependent manner. Mitochondrion Up-regulated by endocannabinoid anandamide/AEA. Consists of an N-terminal biotin carboxylation/carboxylase (BC) domain that catalyzes the ATP-dependent transient carboxylation of the biotin covalently attached to the central biotinyl-binding/biotin carboxyl carrier (BCC) domain (By similarity). The C-terminal carboxyl transferase (CT) domain catalyzes the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA to produce malonyl-CoA (By similarity). The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity. Phosphorylated by AMPK at Ser-212 inactivates the enzyme (PubMed:24913514). Required for the maintenance of skeletal muscle lipid and glucose homeostasis (PubMed:24913514). Normal morphology, fertility, growth rate and lifespan but higher than normal food consumption and fatty acid oxidation rate and decreased fat content in adipose tissue and liver (PubMed:11283375). A high-fat/high-carbohydrate diet results in maintenance of normal insulin and glucose levels with less weight gain and less fat accumulation than wild-type mice (PubMed:12920182). Elevated levels of Ucp2 in adipose tissue and heart but not in skeletal muscle or liver, and elevated levels of Ucp3 in skeletal muscle but not in heart or brown adipose tissue (PubMed:12920182). Significant decrease in body weight, weight of epidydimal fat pads and levels of hepatic triglycerides under a range of dietary conditions including normal chow diet, fasting and refeeding a fat-free high-carbohydrate diet, and a high-fat/high-carbohydrate diet (PubMed:22362781). Up- regulation of lipogenic enzymes under de novo lipogenic conditions but reduced fat accumulation in liver (PubMed:22362781). Primary cultured adipocytes show increased fatty acid and glucose oxidation rates and increased lipolysis (PubMed:15677334). Reduced heart size, reduced Mlycd and malonyl-CoA levels in mutant hearts, reduced myocardial triglyceride levels, higher myocardial oleate and glucose oxidation rates, reduced levels of Ppara and reduced activation of Mtor (PubMed:18487439, PubMed:22730442). However, it has also been reported that mutants show no differences in body weight, food intake, body composition or glucose homeostasis as compared with controls fed on chow or a high-fat diet (PubMed:20368432). nucleotide binding catalytic activity acetyl-CoA carboxylase activity biotin carboxylase activity ATP binding nucleus mitochondrion acetyl-CoA metabolic process lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process metabolic process biotin binding negative regulation of gene expression positive regulation of lipid storage regulation of glucose metabolic process endomembrane system response to organic cyclic compound membrane ligase activity response to nutrient levels negative regulation of fatty acid beta-oxidation response to drug identical protein binding negative regulation of catalytic activity negative regulation of fatty acid oxidation metal ion binding negative regulation of lipid catabolic process protein homotetramerization positive regulation of heart growth energy homeostasis malonyl-CoA biosynthetic process uc008yzi.1 uc008yzi.2 uc008yzi.3 uc008yzi.4 
ENSMUST00000102585.2 Fgf11 ENSMUST00000102585.2 fibroblast growth factor 11, transcript variant 1 (from RefSeq NM_010198.3) ENSMUST00000102585.1 FGF11_MOUSE Fhf3 NM_010198 P70378 Q5F291 uc287zjz.1 uc287zjz.2 Probably involved in nervous system development and function. Nucleus Brain and eye, and in a segmental pattern of the embryonic body wall. In adult olfactory bulb, hippocampus and most concentrated in Purkinje cell layer of the cerebellum. Belongs to the heparin-binding growth factors family. extracellular region nucleus signal transduction growth factor activity uc287zjz.1 uc287zjz.2 
ENSMUST00000102586.5 Slc35g3 ENSMUST00000102586.5 Membrane ; Multi-pass membrane protein (from UniProt Q5F297) AK077181 Amac1 ENSMUST00000102586.1 ENSMUST00000102586.2 ENSMUST00000102586.3 ENSMUST00000102586.4 O35281 Q5F297 S35G3_MOUSE uc287zjr.1 uc287zjr.2 Membrane ; Multi-pass membrane protein Belongs to the SLC35G solute transporter family. Sequence=AAD11967.1; Type=Frameshift; Evidence=; Sequence=AAD26636.1; Type=Erroneous gene model prediction; Evidence=; Sequence=AAD26636.1; Type=Frameshift; Evidence=; Sequence=CAI51954.1; Type=Erroneous gene model prediction; Evidence=; molecular_function biological_process membrane integral component of membrane uc287zjr.1 uc287zjr.2 
ENSMUST00000102588.10 Tmem39b ENSMUST00000102588.10 transmembrane protein 39b, transcript variant 1 (from RefSeq NM_199305.2) ENSMUST00000102588.1 ENSMUST00000102588.2 ENSMUST00000102588.3 ENSMUST00000102588.4 ENSMUST00000102588.5 ENSMUST00000102588.6 ENSMUST00000102588.7 ENSMUST00000102588.8 ENSMUST00000102588.9 NM_199305 Q810L4 TM39B_MOUSE Tmem39b uc008uya.1 uc008uya.2 May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the TMEM39 family. molecular_function cellular_component membrane integral component of membrane uc008uya.1 uc008uya.2 
ENSMUST00000102590.11 Kpna6 ENSMUST00000102590.11 karyopherin subunit alpha 6 (from RefSeq NM_008468.4) ENSMUST00000102590.1 ENSMUST00000102590.10 ENSMUST00000102590.2 ENSMUST00000102590.3 ENSMUST00000102590.4 ENSMUST00000102590.5 ENSMUST00000102590.6 ENSMUST00000102590.7 ENSMUST00000102590.8 ENSMUST00000102590.9 Kpna6 NM_008468 Q8BH30 Q8BH30_MOUSE uc008uxz.1 uc008uxz.2 uc008uxz.3 uc008uxz.4 Functions in nuclear protein import. Belongs to the importin alpha family. nucleus cytoplasm protein import into nucleus protein transport host cell nuclear import signal receptor activity entry of viral genome into host nucleus through nuclear pore complex via importin positive regulation of viral life cycle uc008uxz.1 uc008uxz.2 uc008uxz.3 uc008uxz.4 
ENSMUST00000102591.10 Tmem234 ENSMUST00000102591.10 transmembrane protein 234, transcript variant 1 (from RefSeq NM_029748.3) ENSMUST00000102591.1 ENSMUST00000102591.2 ENSMUST00000102591.3 ENSMUST00000102591.4 ENSMUST00000102591.5 ENSMUST00000102591.6 ENSMUST00000102591.7 ENSMUST00000102591.8 ENSMUST00000102591.9 NM_029748 Q8R1E7 TM234_MOUSE uc008uxo.1 uc008uxo.2 uc008uxo.3 uc008uxo.4 Membrane ; Multi-pass membrane protein Belongs to the TMEM234 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008uxo.1 uc008uxo.2 uc008uxo.3 uc008uxo.4 
ENSMUST00000102593.11 Eif3i ENSMUST00000102593.11 eukaryotic translation initiation factor 3, subunit I (from RefSeq NM_018799.2) EIF3I_MOUSE ENSMUST00000102593.1 ENSMUST00000102593.10 ENSMUST00000102593.2 ENSMUST00000102593.3 ENSMUST00000102593.4 ENSMUST00000102593.5 ENSMUST00000102593.6 ENSMUST00000102593.7 ENSMUST00000102593.8 ENSMUST00000102593.9 Eif3s2 NM_018799 Q9QZD9 Trip1 uc008uxm.1 uc008uxm.2 uc008uxm.3 uc008uxm.4 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Q9QZD9; Q6NZJ6: Eif4g1; NbExp=3; IntAct=EBI-7466616, EBI-8175606; Cytoplasm Phosphorylated by TGF-beta type II receptor. Belongs to the eIF-3 subunit I family. formation of cytoplasmic translation initiation complex cytoplasmic translational initiation translation initiation factor activity protein binding cytoplasm eukaryotic translation initiation factor 3 complex translation translational initiation eukaryotic 43S preinitiation complex enzyme binding eukaryotic 48S preinitiation complex eukaryotic translation initiation factor 3 complex, eIF3m uc008uxm.1 uc008uxm.2 uc008uxm.3 uc008uxm.4 
ENSMUST00000102594.11 Cstpp1 ENSMUST00000102594.11 centriolar satellite-associated tubulin polyglutamylase complex regulator 1, transcript variant 2 (from RefSeq NM_175123.5) CSTP1_MOUSE Cstpp1 ENSMUST00000102594.1 ENSMUST00000102594.10 ENSMUST00000102594.2 ENSMUST00000102594.3 ENSMUST00000102594.4 ENSMUST00000102594.5 ENSMUST00000102594.6 ENSMUST00000102594.7 ENSMUST00000102594.8 ENSMUST00000102594.9 NM_175123 Q3TPK0 Q5HZI4 Q8BHR8 uc008kvt.1 uc008kvt.2 uc008kvt.3 uc008kvt.4 Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding. Interacts with PCM1. Interacts with TTLL1, TPGS1, TPGS2 and LRRC49; the interactions link CSTPP1 to the complex TPGC. Binds to alpha-tubulin. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cytoplasm, cytoskeleton Note=Associated with microtubules. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BHR8-1; Sequence=Displayed; Name=2; IsoId=Q8BHR8-2; Sequence=VSP_024002, VSP_024003; Belongs to the CSTPP1 family. Sequence=BAE37736.1; Type=Frameshift; Evidence=; molecular_function biological_process uc008kvt.1 uc008kvt.2 uc008kvt.3 uc008kvt.4 
ENSMUST00000102596.8 Lck ENSMUST00000102596.8 lymphocyte protein tyrosine kinase, transcript variant 3 (from RefSeq NM_001162433.2) ENSMUST00000102596.1 ENSMUST00000102596.2 ENSMUST00000102596.3 ENSMUST00000102596.4 ENSMUST00000102596.5 ENSMUST00000102596.6 ENSMUST00000102596.7 LCK_MOUSE Lsk-t NM_001162433 P06240 Q61794 Q61795 Q62320 Q91X65 uc008uxj.1 uc008uxj.2 uc008uxj.3 uc008uxj.4 Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T- cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen- bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine- based activation motifs (ITAM) of the cytoplasmic tails of the TCR- gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP (By similarity). Interacts with UNC119; this interaction plays a crucial role in activation of LCK (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; The relative activities of the inhibitory tyrosine-protein kinase CSK and the activating tyrosine-protein phosphatase PTPRC/CD45 determine the level of LCK activity. These interactions allow rapid and efficient activation of LCK in response to TCR stimulation (By similarity). Binds to the cytoplasmic domain of cell surface receptors, such as AXL, CD2, CD4, CD5, CD8, CD44, CD45 and CD122. Also binds to effector molecules, such as PI4K, VAV1, RASA1, FYB1 and to other protein kinases including CDK1, RAF1, ZAP70 and SYK. Binds to phosphatidylinositol 3'-kinase (PI3K) from T-lymphocytes through its SH3 domain and to the tyrosine phosphorylated form of KHDRBS1/p70 through its SH2 domain. Interacts with SQSTM1. Interacts with phosphorylated LIME1. Interacts with CBLB and PTPRH. Interacts with RUNX3. Forms a signaling complex with EPHA1, PTK2B and PI3-KINASE; upon activation by EFNA1 which may regulate T-lymphocytes migration. Associates with ZAP70 and RHOH; these interactions allow LCK-mediated RHOH and CD3 subunit phosphorylation in the presence of functional ZAP70. Interacts with CEACAM1 (via cytoplasmic domain); mediates CEACAM1 phosphorylation resulting in PTPN6 recruitment that dephosphorylates TCR stimulation-induced CD247 and ZAP70. Interacts with FYB2 (By similarity). Interacts with CD160. Interacts with CD48. P06240; P06332: Cd4; NbExp=3; IntAct=EBI-1401, EBI-1404; P06240; P01731: Cd8a; NbExp=2; IntAct=EBI-1401, EBI-1433; P06240; P06800: Ptprc; NbExp=2; IntAct=EBI-1401, EBI-1672; P06240; Q9QXK9: Sh2d2a; NbExp=3; IntAct=EBI-1401, EBI-1644; P06240; Q07666: KHDRBS1; Xeno; NbExp=2; IntAct=EBI-1401, EBI-1364; P06240; P08575: PTPRC; Xeno; NbExp=2; IntAct=EBI-1401, EBI-1341; P06240; O92972; Xeno; NbExp=2; IntAct=EBI-1401, EBI-710506; P06240; P27958; Xeno; NbExp=3; IntAct=EBI-1401, EBI-706378; Cell membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasm, cytosol Note=Present in lipid rafts in an inactive form. Present at a low level in most T-cells, and at an elevated level in LSTRA and Thy19 (T-cell lymphoma) cells. Levels remain relatively constant throughout T- cell ontogeny. The SH2 domain mediates interaction with SQSTM1. Interaction is regulated by Ser-59 phosphorylation (By similarity). Autophosphorylated on Tyr-394, increasing enzymatic activity, this site is dephosphorylated by PTN22. Phosphorylated on Tyr-505 by CSK, decreasing activity. Dephosphorylated by PTPRC/CD45. Dephosphorylation at Tyr-394 by PTPN2 negatively regulates T-cells differentiation (By similarity). Myristoylation is required prior to palmitoylation. Palmitoylation regulates association with the plasma membrane and could be mediated by ZDHHC2. Mice show a dramatic reduction in the level of peripheral T-cells, with 5-10% of wild-type levels. T-cells also exhibit a 10-fold decrease in proliferative response. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. nucleotide binding pericentriolar material immunological synapse phosphotyrosine binding antigen binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein serine/threonine phosphatase activity receptor binding protein binding ATP binding cytoplasm cytosol plasma membrane cell-cell junction protein phosphorylation protein dephosphorylation cellular zinc ion homeostasis activation of cysteine-type endopeptidase activity involved in apoptotic process cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway protein C-terminus binding response to mechanical stimulus response to metal ion positive regulation of gene expression membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation protein kinase binding protein phosphatase binding endocytic vesicle cell differentiation T cell differentiation extrinsic component of cytoplasmic side of plasma membrane positive regulation of heterotypic cell-cell adhesion peptidyl-tyrosine autophosphorylation regulation of cell proliferation SH2 domain binding response to drug positive regulation of tyrosine phosphorylation of STAT protein response to hydrogen peroxide T cell receptor binding CD4 receptor binding CD8 receptor binding identical protein binding phosphatidylinositol 3-kinase binding macromolecular complex binding membrane raft positive regulation of gamma-delta T cell differentiation regulation of regulatory T cell differentiation protein autophosphorylation B cell receptor signaling pathway regulation of T cell receptor signaling pathway positive regulation of T cell activation ATPase binding release of sequestered calcium ion into cytosol positive regulation of uterine smooth muscle contraction glutamatergic synapse postsynaptic specialization, intracellular component positive regulation of leukocyte cell-cell adhesion protein antigen binding positive regulation of intrinsic apoptotic signaling pathway uc008uxj.1 uc008uxj.2 uc008uxj.3 uc008uxj.4 
ENSMUST00000102597.5 Hdac1 ENSMUST00000102597.5 histone deacetylase 1 (from RefSeq NM_008228.3) ENSMUST00000102597.1 ENSMUST00000102597.2 ENSMUST00000102597.3 ENSMUST00000102597.4 Hdac1 NM_008228 Q58E49 Q58E49_MOUSE uc008uxg.1 uc008uxg.2 uc008uxg.3 Reaction=H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]; Xref=Rhea:RHEA:69172, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13707, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:35899, ChEBI:CHEBI:137954; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69173; Evidence=; Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA- COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58197; Evidence=; Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl- [protein]; Xref=Rhea:RHEA:58108, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58109; Evidence=; Nucleus Belongs to the histone deacetylase family. HD Type 1 subfamily. negative regulation of transcription from RNA polymerase II promoter chromatin nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter sequence-specific DNA binding RNA polymerase II transcription factor binding RNA polymerase II repressing transcription factor binding response to amphetamine p53 binding chromatin binding transcription corepressor activity histone deacetylase activity nucleus nucleoplasm cytosol chromatin organization methylation-dependent chromatin silencing regulation of transcription from RNA polymerase II promoter protein deacetylation transcription factor binding positive regulation of cell proliferation negative regulation of cell proliferation negative regulation of gene expression positive regulation of receptor biosynthetic process histone deacetylation Sin3 complex NuRD complex hydrolase activity deacetylase activity enzyme binding response to caffeine NAD-dependent histone deacetylase activity (H3-K14 specific) response to lipopolysaccharide positive regulation of interleukin-1 production positive regulation of tumor necrosis factor production macromolecular complex protein deacetylase activity activating transcription factor binding cellular response to oxidative stress response to drug positive regulation of tyrosine phosphorylation of STAT protein histone deacetylase binding neuron projection negative regulation of neuron apoptotic process negative regulation by host of viral transcription transcription regulatory region DNA binding macromolecular complex binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion metal ion binding protein N-terminus binding perinuclear region of cytoplasm positive regulation of oligodendrocyte differentiation NF-kappaB binding regulation of endopeptidase activity response to hyperoxia negative regulation of androgen receptor signaling pathway repressing transcription factor binding histone H3 deacetylation histone H4 deacetylation cellular response to tumor necrosis factor negative regulation of canonical Wnt signaling pathway positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of type B pancreatic cell apoptotic process negative regulation of peptidyl-lysine acetylation uc008uxg.1 uc008uxg.2 uc008uxg.3 
ENSMUST00000102598.4 Rbbp4 ENSMUST00000102598.4 retinoblastoma binding protein 4, chromatin remodeling factor (from RefSeq NM_009030.3) A2A875 ENSMUST00000102598.1 ENSMUST00000102598.2 ENSMUST00000102598.3 NM_009030 Q60972 RBBP4_MOUSE Rbap48 uc008uwt.1 uc008uwt.2 Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin (By similarity). Subunit of the chromatin assembly factor 1 (CAF-1) complex, which is composed of RBBP4, CHAF1B and CHAF1A (By similarity). Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7 (By similarity). The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex (By similarity). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (By similarity) The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (By similarity). The NuRD complex may also interact with MBD3L1 and MBD3L2 (By similarity). Component of the PRC2 complex, which consists of the core subunits EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:19026780). Forms a monomeric PRC2.2 (class 2) complex consisting of at least SUZ12, RBBP4, AEBP2 and JARID2 (By similarity). Forms a dimeric PRC2.1 (class 1, PRC-PCL) complex consisting of at least SUZ12, RBBP4, and PHF19; PHF19 stabilizes the dimeric structure which enhances PRC2 interaction with chromatin (By similarity). Component of the NURF-1 ISWI chromatin remodeling complex (also called the nucleosome-remodeling factor (NURF) complex) at least composed of SMARCA1 (isoform 2), BPTF, RBBP4 and RBBP7 (PubMed:10866654). Within the complex interacts with isoform 2 of SMARCA1 (By similarity). Component of the BPFT-SMARCA1 complex at least composed of SMARCA1 (isoform 1), BPFT, RBBP4 and RBBP7; the complex is catalytically inactive and does not remodel chromatin (By similarity). Within the complex interacts with isoform 1 of SMARCA1 (By similarity). Interacts with the ISWI chromatin remodeling complex component SMARCA5; the interaction is direct (By similarity). Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1) (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2 (By similarity). The complex exists in quiescent cells where it represses cell cycle-dependent genes (By similarity). It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (By similarity). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (PubMed:28554894). Interacts with ZNF827; the interaction is direct and recruits RBBP4 to telomeres (By similarity). Interacts with MTA1; the interaction is direct and mutually exclusive with binding histone H4 (By similarity). Interacts with ARMC12 (via ARM domains) (By similarity). Interacts with BRCA1 (By similarity). Interacts with CDK2AP1 (By similarity). Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP (PubMed:10866654). Interacts with ERCC6 (By similarity). Interacts with HDAC7 (PubMed:10984530). Interacts with PHF6 (By similarity). Interacts with PWWP2B (PubMed:34180153). Interacts with SPEN/MINT (By similarity). Interacts with SUV39H1 (PubMed:11788710). Nucleus Chromosome, telomere Note=Localizes to chromatin as part of the PRC2 complex. Higher levels in brain, thymus, lung, spleen, kidney, testis, and ovary/uterus; lower levels in heart, liver, and muscle. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. Sequence=AAC52275.1; Type=Frameshift; Evidence=; nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding protein binding nucleus nucleoplasm cytosol DNA replication chromatin organization DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly chromatin remodeling cell cycle DNA-dependent ATPase activity NuRD complex NURF complex chromatin assembly macromolecular complex CAF-1 complex ESC/E(Z) complex histone deacetylase binding uc008uwt.1 uc008uwt.2 
ENSMUST00000102599.4 Sync ENSMUST00000102599.4 syncoilin (from RefSeq NM_023485.3) ENSMUST00000102599.1 ENSMUST00000102599.2 ENSMUST00000102599.3 NM_023485 Q3KP79 Q3TKN1 Q3TUH9 Q8C4J4 Q9CT88 Q9EPM5 SYNCI_MOUSE Sync1 uc008uwr.1 uc008uwr.2 uc008uwr.3 Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins. May link the dystrophin-associated glycoprotein complex (DAPC) to intracellular desmin (DES) filaments. Interacts with DES and DTNA. Q9EPM5; P15331: Prph; NbExp=3; IntAct=EBI-7424051, EBI-1634736; Cytoplasm, perinuclear region te=In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern. Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q9EPM5-1; Sequence=Displayed; Name=2 ; IsoId=Q9EPM5-2; Sequence=VSP_052551, VSP_052552; Name=3 ; IsoId=Q9EPM5-3; Sequence=VSP_052550; Detected strongly in skeletal muscle and heart and weakly in lung (at protein level). Highly expressed in skeletal muscle and lung and weakly in lung and testis. Up-regulated in dystrophic muscle (at protein level). Displays no obvious abnormalities, have a reduced capacity to generate force during isometric contractions in skeletal muscle. Belongs to the intermediate filament family. protein binding cytoplasm cytosol intermediate filament Z disc neuromuscular junction sarcolemma intermediate filament-based process perinuclear region of cytoplasm uc008uwr.1 uc008uwr.2 uc008uwr.3 
ENSMUST00000102600.4 Fndc5 ENSMUST00000102600.4 fibronectin type III domain containing 5 (from RefSeq NM_027402.4) ENSMUST00000102600.1 ENSMUST00000102600.2 ENSMUST00000102600.3 FNDC5_MOUSE Frcp2 NM_027402 Pep Q8K4Z2 Q9DB97 uc008uwe.1 uc008uwe.2 uc008uwe.3 This gene encodes a type I transmembrane protein containing fibronectin type III repeat. The encoded transmembrane protein undergoes proteolytic processing to generate a soluble hormone named irisin that is secreted into the bloodstream. The expression of this gene followed by the secretion of irisin from skeletal muscle is induced by exercise. The ectopic expression of the encoded protein in mice causes an elevation of irisin in blood and improves metabolic health. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ401376.1, BC109184.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## [Irisin]: Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein. Secreted. Note=Imported in peroxisomes through the PEX5 receptor pathway. [Irisin]: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise. In adult, it is highly expressed in skeletal muscle, heart and brain. During embryonic development, it is detected almost exclusively in the skeletal muscle, and at lower level in brain. In skeletal muscle, it is induced after myoblast differentiation, when myotube formation is promoted. Up-regulated by muscular exercise. This effect can be mediated, at least partly, by PPARGC1A. The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated. hormone activity protein binding extracellular region peroxisome peroxisomal membrane endoplasmic reticulum plasma membrane signal transduction response to muscle activity membrane integral component of membrane positive regulation of brown fat cell differentiation uc008uwe.1 uc008uwe.2 uc008uwe.3 
ENSMUST00000102602.8 Trappc1 ENSMUST00000102602.8 trafficking protein particle complex 1 (from RefSeq NM_001024206.2) ENSMUST00000102602.1 ENSMUST00000102602.2 ENSMUST00000102602.3 ENSMUST00000102602.4 ENSMUST00000102602.5 ENSMUST00000102602.6 ENSMUST00000102602.7 NM_001024206 Q5NCF2 TPPC1_MOUSE Trappc1 uc007jpq.1 uc007jpq.2 uc007jpq.3 uc007jpq.4 May play a role in vesicular transport from endoplasmic reticulum to Golgi. Part of the multisubunit transport protein particle (TRAPP) complex. The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation. Golgi apparatus, cis-Golgi network Endoplasmic reticulum Belongs to the TRAPP small subunits family. BET5 subfamily. protein binding endoplasmic reticulum Golgi apparatus ER to Golgi vesicle-mediated transport vesicle-mediated transport Rab guanyl-nucleotide exchange factor activity TRAPP complex uc007jpq.1 uc007jpq.2 uc007jpq.3 uc007jpq.4 
ENSMUST00000102606.10 Slc25a35 ENSMUST00000102606.10 solute carrier family 25, member 35, transcript variant 1 (from RefSeq NM_028048.3) ENSMUST00000102606.1 ENSMUST00000102606.2 ENSMUST00000102606.3 ENSMUST00000102606.4 ENSMUST00000102606.5 ENSMUST00000102606.6 ENSMUST00000102606.7 ENSMUST00000102606.8 ENSMUST00000102606.9 NM_028048 Q3TBP2 Q5SWT3 Q99KM5 Q9D913 S2535_MOUSE uc007jop.1 uc007jop.2 uc007jop.3 Putative antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria. Reaction=a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in); Xref=Rhea:RHEA:76595, ChEBI:CHEBI:16189, ChEBI:CHEBI:28965; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. Sequence=AAH04569.1; Type=Erroneous initiation; Evidence=; Sequence=CAI25535.1; Type=Erroneous gene model prediction; Evidence=; mitochondrion mitochondrial inner membrane membrane integral component of membrane uc007jop.1 uc007jop.2 uc007jop.3 
ENSMUST00000102611.10 Myh10 ENSMUST00000102611.10 myosin, heavy polypeptide 10, non-muscle (from RefSeq NM_175260.2) ENSMUST00000102611.1 ENSMUST00000102611.2 ENSMUST00000102611.3 ENSMUST00000102611.4 ENSMUST00000102611.5 ENSMUST00000102611.6 ENSMUST00000102611.7 ENSMUST00000102611.8 ENSMUST00000102611.9 MYH10_MOUSE NM_175260 Q5SV63 Q61879 uc007jny.1 uc007jny.2 uc007jny.3 Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6 (By similarity). Interacts with ECPAS (By similarity). Interacts with LARP6 (By similarity). Interacts with MCC (By similarity). Interacts with KIF26B (PubMed:20439720). Interacts with CFAP95 (By similarity). Q61879; Q7TNC6: Kif26b; NbExp=3; IntAct=EBI-400918, EBI-15852098; Cell projection, lamellipodium Note=Colocalizes with MCC at the leading edge of migrating cells. In newborn kidney, expressed in the mesenchyme and ureteric buds. The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Phosphorylated by ABL2. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents a conventional non-muscle myosin. This protein should not be confused with the unconventional myosin-10 (MYO10). microfilament motor activity nucleotide binding mitotic cytokinesis in utero embryonic development stress fiber neuron migration plasma membrane repair cardiac septum development motor activity actin binding protein binding calmodulin binding ATP binding cytoplasm cytosol polysome brush border cell cortex exocytosis substrate-dependent cell migration, cell extension nuclear migration cell adhesion axonogenesis axon guidance brain development heart development adult heart development cell proliferation regulation of cell shape myosin complex myosin II complex ATPase activity fourth ventricle development lateral ventricle development third ventricle development cerebellar Purkinje cell layer development lamellipodium actin cytoskeleton organization actin filament-based movement myofibril assembly axon growth cone midbody actin-dependent ATPase activity actomyosin structure organization neuron projection development cleavage furrow RNA stem-loop binding aorta development actomyosin identical protein binding cell projection neuron projection neuronal cell body dendritic spine ADP binding mRNA 5'-UTR binding positive regulation of protein secretion neuromuscular process controlling balance actin filament binding actin filament bundle assembly cardiac myofibril assembly ventricular cardiac muscle cell development retina development in camera-type eye coronary vasculature development actin filament bundle distribution myosin II filament postsynaptic actin cytoskeleton modification of postsynaptic actin cytoskeleton postsynaptic actin cytoskeleton organization glutamatergic synapse regulation of modification of postsynaptic actin cytoskeleton spindle plasma membrane neuromuscular junction uc007jny.1 uc007jny.2 uc007jny.3 
ENSMUST00000102613.8 Pik3r6 ENSMUST00000102613.8 phosphoinositide-3-kinase regulatory subunit 5, transcript variant 2 (from RefSeq NM_001004435.3) ENSMUST00000102613.1 ENSMUST00000102613.2 ENSMUST00000102613.3 ENSMUST00000102613.4 ENSMUST00000102613.5 ENSMUST00000102613.6 ENSMUST00000102613.7 NM_001004435 PI3R6_MOUSE Q3TBT5 Q3U6Q4 Q3UAY4 Q8K323 uc007jns.1 uc007jns.2 uc007jns.3 uc007jns.4 Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G beta-gamma, and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G proteins than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. Heterodimer of a catalytic subunit (PIK3CG) and a regulatory (PIK3R6) subunit. The binding of PIK3R6 to PIK3CG may exclude the binding of PIK3R5 to PIK3CG (PubMed:16476736, PubMed:15797027). Interacts with beta-gamma G protein dimers (PubMed:16476736). Interacts with PDE3B and RAPGEF3; form a signaling complex that regulates phosphatidylinositol 3-kinase gamma in angiogenesis (By similarity). Q3U6Q4; Q9JHG7: Pik3cg; NbExp=4; IntAct=EBI-4303950, EBI-644372; Q3U6Q4; P48736: PIK3CG; Xeno; NbExp=6; IntAct=EBI-4303950, EBI-1030384; Cytoplasm Cell membrane ; Peripheral membrane protein Note=Translocated to the plasma membrane in a Ras-dependent manner (PubMed:19906996). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U6Q4-1; Sequence=Displayed; Name=2; IsoId=Q3U6Q4-2; Sequence=VSP_018257; Name=3; IsoId=Q3U6Q4-3; Sequence=VSP_018255, VSP_018256; Highly expressed in heart. In a lower extent, also expressed in brain, spleen, lung, liver, kidney, prostate, thyroid, salivary gland, dendritic cells, macrophages and neutrophils. angiogenesis protein binding cytoplasm plasma membrane phosphatidylinositol 3-kinase complex phosphatidylinositol 3-kinase complex, class IB G-protein coupled receptor signaling pathway membrane regulation of natural killer cell mediated cytotoxicity positive regulation of MAP kinase activity regulation of phosphatidylinositol 3-kinase activity positive regulation of T cell differentiation positive regulation of angiogenesis phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity uc007jns.1 uc007jns.2 uc007jns.3 uc007jns.4 
ENSMUST00000102616.8 Tekt2 ENSMUST00000102616.8 tektin 2, transcript variant 2 (from RefSeq NM_001357262.1) ENSMUST00000102616.1 ENSMUST00000102616.2 ENSMUST00000102616.3 ENSMUST00000102616.4 ENSMUST00000102616.5 ENSMUST00000102616.6 ENSMUST00000102616.7 NM_001357262 Q922G7 Q9WVR0 TEKT2_MOUSE uc008utf.1 uc008utf.2 uc008utf.3 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme (PubMed:15340058). Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia (PubMed:15340058). Forms filamentous polymers in the walls of ciliary and flagellar microtubules (PubMed:15340058). May interact with CCDC172 (PubMed:24394471). Interacts with TEKT3 (By similarity). Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme Cytoplasm, cytoskeleton, microtubule organizing center Note=Colocalized with CCDC172 at the perinuclear region (PubMed:24394471). Expressed in the testes (at protein level). Localized in the flagella of elongating spermatids from developmental step 15 to maturity. Tyrosine phosphorylated. Belongs to the tektin family. cytoplasm microtubule organizing center cytoskeleton microtubule cilium microtubule cytoskeleton cell projection organization flagellated sperm motility motile cilium inner dynein arm assembly cell projection cilium assembly cilium movement involved in cell motility uc008utf.1 uc008utf.2 uc008utf.3 
ENSMUST00000102617.5 Adprs ENSMUST00000102617.5 ADP-ribosylserine hydrolase (from RefSeq NM_133883.2) A3KFY3 ADPRS_MOUSE Adprhl2 Arh3 ENSMUST00000102617.1 ENSMUST00000102617.2 ENSMUST00000102617.3 ENSMUST00000102617.4 NM_133883 Q80UW9 Q8CG72 Q8R575 Q921U6 uc008ute.1 uc008ute.2 uc008ute.3 ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP- ribose and acts on different substrates, such as proteins ADP- ribosylated on serine and threonine, free poly(ADP-ribose) and O- acetyl-ADP-D-ribose (By similarity). Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response (By similarity). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (By similarity). Does not hydrolyze ADP- ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds (By similarity). Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (PubMed:24191052, PubMed:30830864). Also hydrolyzes free poly(ADP-ribose) in mitochondria (By similarity). Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins (By similarity). Specifically degrades 1''-O-acetyl-ADP-D- ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl- ADP-D-ribose isomers (By similarity). Reaction=[(1''->2')-ADP-alpha-D-ribose](n) + H2O = [(1''->2')-ADP- alpha-D-ribose](n-1) + ADP-D-ribose; Xref=Rhea:RHEA:52216, Rhea:RHEA- COMP:16922, Rhea:RHEA-COMP:16923, ChEBI:CHEBI:15377, ChEBI:CHEBI:57967, ChEBI:CHEBI:142512; EC=3.2.1.143; Evidence=; Reaction=1''-O-acetyl-ADP-alpha-D-ribose + H2O = acetate + ADP-D-ribose + H(+); Xref=Rhea:RHEA:58112, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:142511; Evidence=; Reaction=H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] = ADP-D-ribose + L- seryl-[protein]; Xref=Rhea:RHEA:58256, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:15091, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:57967, ChEBI:CHEBI:142556; Evidence=; Reaction=alpha-NAD(+) + H2O = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:68792, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57967, ChEBI:CHEBI:77017; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions per subunit. ; The protein undergoes a dramatic conformational switch from closed to open states upon substrate-binding, which enables specific substrate recognition for the 1''-O-linkage. The glutamate flap (Glu-47) blocks substrate entrance to Mg(2+) in the unliganded closed state. In presence of substrate, Glu-47 is ejected from the active site: this closed-to-open transition significantly widens the substrate-binding channel and precisely positions the scissile 1''-O- linkage for cleavage while securing tightly 2'- and 3'-hydroxyls of ADP-ribose. Monomer. Nucleus toplasm Chromosome Mitochondrion matrix Note=Recruited to DNA lesion regions following DNA damage; ADP-D-ribose-recognition is required for recruitment to DNA damage sites. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CG72-1; Sequence=Displayed; Name=2; IsoId=Q8CG72-2; Sequence=VSP_023037; Ubiquitous. Knockout mice are phenotypically normal and fertile (PubMed:30830864). 1 hour induced brain ischemia results in 100% fatality within 24 hours (PubMed:30830864). 30 minutes of induced brain ischemia results in an increase in infarct size in the cortex, hippocampus, and striatum (PubMed:30830864). Increased number of cortical neurons with nucleus-accumulated poly(ADP-ribose) and higher abundance of poly(ADP-ribose) in general (PubMed:30830864). Belongs to the ADP-ribosylglycohydrolase family. magnesium ion binding hydrolase activity, hydrolyzing O-glycosyl compounds poly(ADP-ribose) glycohydrolase activity nucleus nucleoplasm chromosome cytoplasm mitochondrion mitochondrial matrix DNA repair cellular response to DNA damage stimulus nuclear body hydrolase activity metal ion binding O-acetyl-ADP-ribose deacetylase activity cellular response to superoxide uc008ute.1 uc008ute.2 uc008ute.3 
ENSMUST00000102620.10 Fndc7 ENSMUST00000102620.10 fibronectin type III domain containing 7, transcript variant 1 (from RefSeq NM_177091.5) A2AED1 A2AED2 A2AED3 ENSMUST00000102620.1 ENSMUST00000102620.2 ENSMUST00000102620.3 ENSMUST00000102620.4 ENSMUST00000102620.5 ENSMUST00000102620.6 ENSMUST00000102620.7 ENSMUST00000102620.8 ENSMUST00000102620.9 FNDC7_MOUSE NM_177091 Q14DI4 Q14DS1 Q3TNR1 Q8BW61 Q8BW83 uc008qzv.1 uc008qzv.2 uc008qzv.3 uc008qzv.4 Secreted Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AED3-1; Sequence=Displayed; Name=2; IsoId=A2AED3-3; Sequence=VSP_024610, VSP_024612, VSP_024613; Name=3; IsoId=A2AED3-4; Sequence=VSP_024611; Sequence=BC113188; Type=Frameshift; Evidence=; Sequence=CAM20604.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM20605.1; Type=Erroneous gene model prediction; Evidence=; molecular_function cellular_component extracellular region biological_process uc008qzv.1 uc008qzv.2 uc008qzv.3 uc008qzv.4 
ENSMUST00000102621.11 Stxbp3 ENSMUST00000102621.11 syntaxin binding protein 3 (from RefSeq NM_011504.1) ENSMUST00000102621.1 ENSMUST00000102621.10 ENSMUST00000102621.2 ENSMUST00000102621.3 ENSMUST00000102621.4 ENSMUST00000102621.5 ENSMUST00000102621.6 ENSMUST00000102621.7 ENSMUST00000102621.8 ENSMUST00000102621.9 NM_011504 Q3TE73 Q3U2S2 Q3U8D9 Q3UA91 Q3UUB0 Q60770 STXB3_MOUSE Stxbp3a Unc18c uc008qzr.1 uc008qzr.2 uc008qzr.3 uc008qzr.4 uc008qzr.5 Together with STX4 and VAMP2, may play a role in insulin- dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. Interacts with STX4. Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion. Q60770; Q08850: Stx4; Xeno; NbExp=4; IntAct=EBI-8430169, EBI-918243; Q60770; P63045: Vamp2; Xeno; NbExp=2; IntAct=EBI-8430169, EBI-520880; Q60770-1; P70452: Stx4; NbExp=3; IntAct=EBI-15639434, EBI-645716; Cytoplasm, cytosol Cell membrane Note=In platelets, predominantly cytosolic. Low amounts membrane-associated (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60770-1; Sequence=Displayed; Name=2; IsoId=Q60770-2; Sequence=VSP_037061, VSP_037062; Ubiquitously expressed in all tissues tested. Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4. Belongs to the STXBP/unc-18/SEC1 family. Sequence=BAE41375.1; Type=Frameshift; Evidence=; cellular glucose homeostasis protein binding cytoplasm cytosol plasma membrane exocytosis vesicle docking involved in exocytosis brain development protein transport membrane vesicle-mediated transport basolateral plasma membrane apical plasma membrane syntaxin-1 binding syntaxin binding protein to membrane docking insulin secretion platelet alpha granule response to insulin specific granule neutrophil degranulation phagocytic vesicle negative regulation of calcium ion-dependent exocytosis negative regulation of glucose import protein heterooligomerization platelet aggregation tertiary granule cellular response to interferon-gamma presynapse uc008qzr.1 uc008qzr.2 uc008qzr.3 uc008qzr.4 uc008qzr.5 
ENSMUST00000102622.2 Or9m2 ENSMUST00000102622.2 olfactory receptor family 9 subfamily M member 2 (from RefSeq NM_146645.2) A2BHP7 A2BHP7_MOUSE ENSMUST00000102622.1 NM_146645 Olfr1154 Olfr1158 Or9m2 uc008kpc.1 uc008kpc.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript completely matching the reference genome was available for the full length of the gene. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kpc.1 uc008kpc.2 
ENSMUST00000102624.2 Or5w10 ENSMUST00000102624.2 olfactory receptor family 5 subfamily W member 10 (from RefSeq NM_146349.2) ENSMUST00000102624.1 NM_146349 Olfr1128 Or5w10 Q7TR47 Q7TR47_MOUSE uc008kod.1 uc008kod.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC104065.1, BC104064.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kod.1 uc008kod.2 
ENSMUST00000102626.10 Ptpn5 ENSMUST00000102626.10 protein tyrosine phosphatase, non-receptor type 5, transcript variant 1 (from RefSeq NM_013643.3) ENSMUST00000102626.1 ENSMUST00000102626.2 ENSMUST00000102626.3 ENSMUST00000102626.4 ENSMUST00000102626.5 ENSMUST00000102626.6 ENSMUST00000102626.7 ENSMUST00000102626.8 ENSMUST00000102626.9 NM_013643 P54830 PTN5_MOUSE Q64694 Q8CAN0 uc009hab.1 uc009hab.2 uc009hab.3 uc009hab.4 uc009hab.5 May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= P54830-1; Q16539-1: MAPK14; Xeno; NbExp=6; IntAct=EBI-16067443, EBI-15834191; [Isoform STEP61]: Endoplasmic reticulum membrane; Multi-pass membrane protein. [Isoform STEP46]: Cytoplasm. Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=STEP61; IsoId=P54830-1; Sequence=Displayed; Name=STEP46; IsoId=P54830-2; Sequence=VSP_005126; Name=STEP38; IsoId=P54830-3; Sequence=VSP_005127, VSP_005128; Name=STEP20; IsoId=P54830-4; Sequence=VSP_005126, VSP_005127, VSP_005128; STEP20 is expressed only in the CNS. Phosphorylation at Ser-221 by PKA deactivates PTPN5. Phosphorylation at Thr-231 and Ser-244 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin- mediated degradation of the active phosphatase (By similarity). [Isoform STEP38]: Lacks the catalytic domain. [Isoform STEP20]: Lacks the catalytic domain. Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. phosphotyrosine binding positive regulation of protein phosphorylation positive regulation of receptor internalization phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol protein dephosphorylation synaptic vesicle positive regulation of neuron projection development membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity protein kinase binding axon glutamate receptor binding peptidyl-tyrosine dephosphorylation exploration behavior response to immobilization stress protein homodimerization activity neuronal cell body perikaryon negative regulation of MAP kinase activity mitogen-activated protein kinase binding synaptic membrane positive regulation of long-term synaptic potentiation positive regulation of neuron death positive regulation of protein targeting to mitochondrion proximal dendrite positive regulation of response to drug uc009hab.1 uc009hab.2 uc009hab.3 uc009hab.4 uc009hab.5 
ENSMUST00000102628.11 Yrdc ENSMUST00000102628.11 yrdC domain containing (E.coli) (from RefSeq NM_153566.2) B1ARW9 B1ARX2 ENSMUST00000102628.1 ENSMUST00000102628.10 ENSMUST00000102628.2 ENSMUST00000102628.3 ENSMUST00000102628.4 ENSMUST00000102628.5 ENSMUST00000102628.6 ENSMUST00000102628.7 ENSMUST00000102628.8 ENSMUST00000102628.9 Irip NM_153566 Q3U5F4 Q7TSY0 Q8CII1 YRDC_MOUSE uc008urf.1 uc008urf.2 uc008urf.3 uc008urf.4 Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs (By similarity). May regulate the activity of some transporters (PubMed:16024787). Reaction=ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L- threonylcarbamoyladenylate; Xref=Rhea:RHEA:36407, ChEBI:CHEBI:15377, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57926, ChEBI:CHEBI:73682; EC=2.7.7.87; Evidence=; Interacts with RSC1A1. Cytoplasm Mitochondrion Cell membrane ; Peripheral membrane protein Note=A large fraction localizes in the cytoplasm, whereas a smaller fraction is imported to mitochondria. Widely expressed. Expressed at higher level in testis, secretory, and endocrine organs. By ischemia/reperfusion and endotoxemia. The mitochondrial targeting sequence (MTS) is weak and only mediates import of a small fraction of YRDC in mitochondria. Belongs to the SUA5 family. Sequence=AAH23823.1; Type=Erroneous initiation; Evidence=; Sequence=AAP37032.1; Type=Erroneous initiation; Evidence=; Sequence=CAM16101.1; Type=Erroneous initiation; Evidence=; Sequence=CAP19076.1; Type=Erroneous gene model prediction; Evidence=; tRNA binding double-stranded RNA binding protein binding cytoplasm mitochondrion regulation of translational fidelity membrane nucleotidyltransferase activity negative regulation of transport uc008urf.1 uc008urf.2 uc008urf.3 uc008urf.4 
ENSMUST00000102629.8 Psrc1 ENSMUST00000102629.8 proline/serine-rich coiled-coil 1, transcript variant 1 (from RefSeq NM_001190161.1) Dda3 ENSMUST00000102629.1 ENSMUST00000102629.2 ENSMUST00000102629.3 ENSMUST00000102629.4 ENSMUST00000102629.5 ENSMUST00000102629.6 ENSMUST00000102629.7 NM_001190161 PSRC1_MOUSE Q8K4L8 Q9D0P7 Q9QXY5 uc008qyw.1 uc008qyw.2 uc008qyw.3 uc008qyw.4 Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity). Interacts with APC2 (PubMed:17310996). Interacts with KIF2A (By similarity). Interacts with ANKRD53; recruits ANKRD53 to the spindle during mitosis (By similarity). Cytoplasm Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase (By similarity). Highly expressed in heart, brain and lung. Weaker expression in kidney and testis. Induced by adriamycin and mitomycin C, in a p53-dependent manner, in NIH3T3 cells. This induction is inhibited by actinomycin D. Also induced by cisplatin in a p73-dependent manner in embryonic cells. Phosphorylated during mitosis. Belongs to the PSRC1 family. spindle pole microtubule bundle formation protein binding nucleoplasm cytoplasm spindle cytosol cytoskeleton spindle microtubule cell cycle mitotic metaphase plate congression microtubule binding cellular process microtubule cytoskeleton negative regulation of cell growth midbody positive regulation of microtubule polymerization positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription, DNA-templated cell division regulation of mitotic spindle organization uc008qyw.1 uc008qyw.2 uc008qyw.3 uc008qyw.4 
ENSMUST00000102632.7 Sort1 ENSMUST00000102632.7 sortilin 1, transcript variant 2 (from RefSeq NM_019972.3) A2AEE8 ENSMUST00000102632.1 ENSMUST00000102632.2 ENSMUST00000102632.3 ENSMUST00000102632.4 ENSMUST00000102632.5 ENSMUST00000102632.6 NM_019972 Q3UHE2 Q6PHU5 Q8K043 Q9QXW6 SORT_MOUSE Sort1 uc008qyr.1 uc008qyr.2 uc008qyr.3 uc008qyr.4 Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP, NTS and GM2A. Forms a complex with NGFR which binds specifically to the precursor forms of NGFB (proNGFB) and BDNF (proBDNF). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; may regulate their anterograde axonal transport and signaling (By similarity). Interacts with LPL (PubMed:10085125). Interacts with PSAP (PubMed:15236332). Interacts with SLC2A4 (PubMed:15992544). Interacts with NRADD and NGFR (PubMed:19407813). Interaction with NRADD protects against degradation in the lysosome. Interacts with CLN5 (By similarity). Interacts with GRN; this interaction mediates endocytosis and lysosome delivery of progranulin; interaction occurs at the neuronal cell surface in a stressed nervous system (By similarity). Interacts with the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35; which is involved in retrograde trafficking of the receptor from endosomes to the Golgi apparatus (By similarity). Interacts with SMPD1; the interaction is required for SMPD1 targeting to lysosomes (By similarity). Q6PHU5; P12023: App; NbExp=3; IntAct=EBI-6985663, EBI-78814; Q6PHU5; P97438: Kcnk2; NbExp=4; IntAct=EBI-6985663, EBI-7091062; Q6PHU5; Q8CJ26: Nradd; NbExp=5; IntAct=EBI-6985663, EBI-6985725; Q6PHU5; P15209: Ntrk2; NbExp=3; IntAct=EBI-6985663, EBI-309647; Q6PHU5; Q9EQH3: Vps35; NbExp=3; IntAct=EBI-6985663, EBI-775825; Golgi apparatus, Golgi stack membrane ; Single-pass type I membrane protein Endosome membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Nucleus membrane ; Single-pass type I membrane protein Cell membrane ; Single-pass type I membrane protein ; Extracellular side Lysosome membrane ; Single-pass type I membrane protein Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PHU5-1; Sequence=Displayed; Name=2; IsoId=Q6PHU5-2; Sequence=VSP_016650; Expressed in the brain, particularly the piriform cortex, the cerebral cortex and the hippocampus. Expressed in the ectoderm at 7.5 dpc and within the germ cell layers at 8.5 dpc. Expressed within the neural epithelium and the neural tube at 9.5 dpc and subsequently expressed in the nervous system throughout development. Expression in the proliferative zones of the central nervous system declines between 14.5 dpc and 16.5 dpc, while expression remains high in the cerebral cortex and the neural retina. Expressed in the pituitary and the sensory epithelia throughout development. During adipocyte differentiation. The N-terminal propeptide may facilitate precursor transport within the Golgi stack. Intrachain binding of the N-terminal propeptide and the extracellular domain may also inhibit premature ligand binding (By similarity). The extracellular domain may be shed following protease cleavage in some cell types. The N-terminal propeptide is cleaved by furin and possibly other homologous proteases. Phosphorylation at Ser-819 facilitates the interaction with GGA1. Palmitoylated. Undergoes cysteine S-palmitoylation which promotes the partitioning of the receptor into an endosomal membrane subdomain where it can interact with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus. Belongs to the VPS10-related sortilin family. SORT1 subfamily. ossification protein binding nucleus lysosome lysosomal membrane endosome early endosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol plasma membrane clathrin-coated pit post-Golgi vesicle-mediated transport Golgi to endosome transport endocytosis G-protein coupled receptor signaling pathway neuropeptide signaling pathway multicellular organism development endosome to lysosome transport extrinsic apoptotic signaling pathway via death domain receptors cell surface endosome membrane nerve growth factor receptor activity regulation of gene expression myotube differentiation membrane integral component of membrane vesicle organization enzyme binding clathrin-coated vesicle trans-Golgi network transport vesicle cell differentiation neurotensin receptor activity, non-G-protein coupled dendrite cytoplasmic vesicle membrane cytoplasmic vesicle nuclear membrane endosome transport via multivesicular body sorting pathway Golgi cisterna membrane response to insulin nerve growth factor signaling pathway neuronal cell body intracellular membrane-bounded organelle negative regulation of fat cell differentiation glucose import neurotrophin TRK receptor signaling pathway plasma membrane to endosome transport nerve growth factor binding perinuclear region of cytoplasm negative regulation of lipoprotein lipase activity positive regulation of epithelial cell apoptotic process uc008qyr.1 uc008qyr.2 uc008qyr.3 uc008qyr.4 
ENSMUST00000102633.9 Atxn7l2 ENSMUST00000102633.9 ataxin 7-like 2, transcript variant 2 (from RefSeq NM_175183.6) Atxn7l2 ENSMUST00000102633.1 ENSMUST00000102633.2 ENSMUST00000102633.3 ENSMUST00000102633.4 ENSMUST00000102633.5 ENSMUST00000102633.6 ENSMUST00000102633.7 ENSMUST00000102633.8 NM_175183 Q8C8K6 Q8C8K6_MOUSE uc008qyl.1 uc008qyl.2 uc008qyl.3 uc008qyl.4 molecular_function cellular_component biological_process uc008qyl.1 uc008qyl.2 uc008qyl.3 uc008qyl.4 
ENSMUST00000102635.10 Myocd ENSMUST00000102635.10 myocardin, transcript variant 2 (from RefSeq NM_146386.4) Bsac2 ENSMUST00000102635.1 ENSMUST00000102635.2 ENSMUST00000102635.3 ENSMUST00000102635.4 ENSMUST00000102635.5 ENSMUST00000102635.6 ENSMUST00000102635.7 ENSMUST00000102635.8 ENSMUST00000102635.9 MYCD_MOUSE Mycd NM_146386 Q5SS65 Q6W8X1 Q8C3W6 Q8VIL4 Q8VIM5 Srfcp uc007jkz.1 uc007jkz.2 uc007jkz.3 uc007jkz.4 uc007jkz.5 Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters. Homodimer. Interacts with MLLT7/FOXO4 (By similarity). Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation. Interacts (via C-terminal) with EP300 (via CREB-binding domain). Interacts with HDAC4 and HDAC5. Interacts with MEF2C. Q8VIM5-1; P10085: Myod1; NbExp=2; IntAct=EBI-15626132, EBI-4405734; Q8VIM5-1; Q9Y6Q9: NCOA3; Xeno; NbExp=5; IntAct=EBI-15626132, EBI-81196; Q8VIM5-1; Q04206: RELA; Xeno; NbExp=2; IntAct=EBI-15626132, EBI-73886; Q8VIM5-1; Q04206-1: RELA; Xeno; NbExp=2; IntAct=EBI-15626132, EBI-10826776; Nucleus speckle te=Nuclear, with a punctate intranuclear pattern with exclusion from nuclei. Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=MYOCD-v2; IsoId=Q8VIM5-1; Sequence=Displayed; Name=2; Synonyms=BSAC2A, Myocardin A, MYOCD-v5; IsoId=Q8VIM5-2; Sequence=VSP_007662, VSP_007663; Name=3; Synonyms==Myocardin A, MYOCD-v1; IsoId=Q8VIM5-3; Sequence=VSP_007663; Name=4; Synonyms=MYOCD-v3; IsoId=Q8VIM5-4; Sequence=VSP_041684, VSP_007663; Name=5; Synonyms=MYOCD-v4; IsoId=Q8VIM5-5; Sequence=VSP_041684; Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder and uterus. Isoform 1 and isoform 3 are predominantly expressed in cardiac muscle whereas isoform 4 and isoform 5 are predominantly expressed in SMC-rich tissues. Isoform 3 is the most abundant isoform in the heart from embryo to adult. Detected in the cardiac crescent at 7.75 dpc and in the linear heart tube at 8.0 dpc and the developing atrial and aortic ventricular chambers until birth. Also detected in a subset of vascular and visceral smooth muscle cells: aortic arch arteries at 9.5 dpc; walls of the esophagus, dorsal aorta, pulmonary outflow tract, lung, gut, stomach, small intestine, bladder, and the head mesenchyme at 13.5 dpc until birth. Not detected in skeletal muscle cells. The C-terminal region contains a general transcription activation domain. The N-terminal region, comprising a basic and a Gln- rich domain, confers transcriptional potency and specificity by mediating association with the MADS box of SRF. The basic domain may be required for nuclear localization. The SAP domain is important for transactivation and ternary complex formation. Phosphorylation negatively regulates transcriptional activity. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding regulation of cell growth by extracellular stimulus vasculogenesis response to hypoxia cardiac ventricle development positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation transcription coactivator activity protein binding nucleus regulation of transcription from RNA polymerase II promoter heart development transcription factor binding positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of gene expression negative regulation of cardiac muscle cell apoptotic process positive regulation of epithelial to mesenchymal transition negative regulation of myotube differentiation nuclear speck positive regulation of transforming growth factor beta receptor signaling pathway histone acetyltransferase binding regulation of histone acetylation hepatic stellate cell activation vascular smooth muscle cell differentiation muscle cell differentiation histone deacetylase binding positive regulation of DNA binding cellular component maintenance regulation of myoblast differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle contraction lung alveolus development digestive tract development positive regulation of sequence-specific DNA binding transcription factor activity smooth muscle cell differentiation regulation of smooth muscle cell differentiation positive regulation of smooth muscle cell differentiation cardiac muscle cell differentiation ventricular cardiac muscle cell differentiation uterus development urinary bladder development cell growth involved in cardiac muscle cell development RNA polymerase II sequence-specific DNA binding transcription factor binding R-SMAD binding SRF-myogenin-E12 complex ductus arteriosus closure negative regulation of beta-amyloid clearance regulation of phenotypic switching positive regulation of transcription from RNA polymerase II promoter involved in heart development negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration negative regulation of platelet-derived growth factor receptor-beta signaling pathway positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation positive regulation of cardiac vascular smooth muscle cell differentiation positive regulation of cardiac muscle cell differentiation negative regulation of skeletal muscle cell differentiation core promoter proximal region sequence-specific DNA binding uc007jkz.1 uc007jkz.2 uc007jkz.3 uc007jkz.4 uc007jkz.5 
ENSMUST00000102636.4 Akirin1 ENSMUST00000102636.4 akirin 1 (from RefSeq NM_023423.3) AKIR1_MOUSE Akirin1 ENSMUST00000102636.1 ENSMUST00000102636.2 ENSMUST00000102636.3 MNCb-2831 Mighty NM_023423 Q99LF1 Q9JJB7 uc008upv.1 uc008upv.2 uc008upv.3 Molecular adapter that acts as a bridge between proteins, and which is involved skeletal muscle development (PubMed:18255059, PubMed:19406121, PubMed:30746755). Functions as a signal transducer for MSTN during skeletal muscle regeneration and myogenesis (PubMed:18255059, PubMed:19406121). May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway (PubMed:19406121). In contrast to AKIRIN2, not involved in nuclear import of proteasomes (By similarity). Nucleus Expressed in macrophages and satellite cells. Up-regulated in activated satellite cells and in the regenerating muscle (PubMed:19406121). Down-regulated by MSTN in skeletal muscle (PubMed:19406121, PubMed:18255059, PubMed:23516508). Down-regulated by dexamethasone by a MSTN (PubMed:23516508). Mice grow normally and do not display gross developmental abnormalities (PubMed:18066067). Embryonic fibroblasts obtained from null mutant mice do not express Akirin1 (PubMed:18066067). 'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal. Belongs to the akirin family. Sequence=BAA95077.1; Type=Erroneous initiation; Evidence=; molecular_function nucleus nucleoplasm positive regulation of lamellipodium assembly positive regulation of macrophage chemotaxis myoblast migration involved in skeletal muscle regeneration nuclear membrane positive regulation of myoblast differentiation negative regulation of skeletal muscle satellite cell proliferation negative regulation of satellite cell differentiation uc008upv.1 uc008upv.2 uc008upv.3 
ENSMUST00000102640.2 Oxct2a ENSMUST00000102640.2 3-oxoacid CoA transferase 2A (from RefSeq NM_022033.4) B9EHG5 ENSMUST00000102640.1 NM_022033 Q9JJN4 SCO2A_MOUSE uc008uph.1 uc008uph.2 uc008uph.3 uc008uph.4 uc008uph.5 Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa. Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate; Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973, ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5; Evidence=; Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. Homodimer. Mitochondrion Belongs to the 3-oxoacid CoA-transferase family. mitochondrion succinyl-CoA metabolic process 3-oxoacid CoA-transferase activity CoA-transferase activity transferase activity cellular ketone body metabolic process ketone body catabolic process uc008uph.1 uc008uph.2 uc008uph.3 uc008uph.4 uc008uph.5 
ENSMUST00000102641.10 Bmp8a ENSMUST00000102641.10 bone morphogenetic protein 8a, transcript variant 2 (from RefSeq NM_007558.3) BMP8A_MOUSE Bmp-8 Bmp8 ENSMUST00000102641.1 ENSMUST00000102641.2 ENSMUST00000102641.3 ENSMUST00000102641.4 ENSMUST00000102641.5 ENSMUST00000102641.6 ENSMUST00000102641.7 ENSMUST00000102641.8 ENSMUST00000102641.9 NM_007558 P34821 uc008upg.1 uc008upg.2 uc008upg.3 uc008upg.4 uc008upg.5 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. Mice lacking a functional copy of this gene exhibit degeneration of germ cells and the epididymal epithelium. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 4. [provided by RefSeq, Jul 2016]. Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance (PubMed:9463357, PubMed:12925636, PubMed:28465413). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A (By similarity). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway (PubMed:28465413). Homodimer; disulfide-linked. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P34821-1; Sequence=Displayed; Name=2; IsoId=P34821-2; Sequence=VSP_046527; Expressed in testis. expressed in trophoblast cells of the labyrinthine region of the placenta and in the inner root sheath of hair follicles of early postnatal skin (PubMed:8843393). Expressed predominantly in the neonatal mouse spermatogonia (PubMed:28465413). Extensive expression found in 8-day embryos, fell drastically in 10-day embryos and virtually absent in 17-day embryos. Expressed during specific stages of spermatogenesis, with the highest levels in stage 6-8 round spermatids after 3 weeks of age. By dexamethasone in calvarial osteoblasts. Deletion mutant mice show normal embryonic and postnatal development. Homozygous mutant females have normal fertility. Males do not show germ cell defects during the initiation of spermatogenesis. However, germ cell degeneration is observed in about half of adult males. Belongs to the TGF-beta family. ossification osteoblast differentiation diet induced thermogenesis cytokine activity transforming growth factor beta receptor binding extracellular region extracellular space transforming growth factor beta receptor signaling pathway multicellular organism development germ cell development spermatogenesis growth factor activity positive regulation of pathway-restricted SMAD protein phosphorylation cell differentiation regulation of apoptotic process regulation of MAPK cascade negative regulation of insulin secretion cell development cartilage development SMAD protein signal transduction energy homeostasis uc008upg.1 uc008upg.2 uc008upg.3 uc008upg.4 uc008upg.5 
ENSMUST00000102642.9 Ube2l6 ENSMUST00000102642.9 ubiquitin-conjugating enzyme E2L 6 (from RefSeq NM_019949.2) ENSMUST00000102642.1 ENSMUST00000102642.2 ENSMUST00000102642.3 ENSMUST00000102642.4 ENSMUST00000102642.5 ENSMUST00000102642.6 ENSMUST00000102642.7 ENSMUST00000102642.8 NM_019949 Q3U8R0 Q922F1 Q9CQN0 Q9QZU9 UB2L6_MOUSE Ubce8 uc012byn.1 uc012byn.2 uc012byn.3 Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence= Protein modification; protein ubiquitination. Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated). ISGylated. Belongs to the ubiquitin-conjugating enzyme family. Sequence=AAD55978.1; Type=Erroneous initiation; Evidence=; ubiquitin ligase complex nucleotide binding protein binding ATP binding ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity ubiquitin-like protein transferase activity modification-dependent protein catabolic process ubiquitin protein ligase binding ISG15-protein conjugation ISG15 transferase activity ubiquitin binding ubiquitin conjugating enzyme activity uc012byn.1 uc012byn.2 uc012byn.3 
ENSMUST00000102645.4 Med19 ENSMUST00000102645.4 mediator complex subunit 19 (from RefSeq NM_025885.4) ENSMUST00000102645.1 ENSMUST00000102645.2 ENSMUST00000102645.3 MED19_MOUSE NM_025885 Q80XM2 Q8C1S0 Q8R3G3 uc008kiy.1 uc008kiy.2 uc008kiy.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Q8C1S0; Q9CXU1: Med31; NbExp=2; IntAct=EBI-398761, EBI-309355; Q8C1S0; O95402: MED26; Xeno; NbExp=2; IntAct=EBI-398761, EBI-394392; Nucleus Belongs to the Mediator complex subunit 19 family. transcription cofactor activity protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter transcription factor binding mediator complex nuclear body positive regulation of transcription from RNA polymerase II promoter uc008kiy.1 uc008kiy.2 uc008kiy.3 
ENSMUST00000102648.6 Oxct2b ENSMUST00000102648.6 3-oxoacid CoA transferase 2B (from RefSeq NM_181859.3) A0A0R4J198 A0A0R4J198_MOUSE ENSMUST00000102648.1 ENSMUST00000102648.2 ENSMUST00000102648.3 ENSMUST00000102648.4 ENSMUST00000102648.5 NM_181859 Oxct2b uc008uou.1 uc008uou.2 uc008uou.3 uc008uou.4 Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate; Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973, ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5; Evidence=; Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. Mitochondrion Belongs to the 3-oxoacid CoA-transferase family. mitochondrion 3-oxoacid CoA-transferase activity CoA-transferase activity transferase activity ketone body catabolic process uc008uou.1 uc008uou.2 uc008uou.3 uc008uou.4 
ENSMUST00000102649.4 Trit1 ENSMUST00000102649.4 tRNA isopentenyltransferase 1, transcript variant 1 (from RefSeq NM_025873.3) B1ARS6 ENSMUST00000102649.1 ENSMUST00000102649.2 ENSMUST00000102649.3 Ipt MOD5_MOUSE NM_025873 Q80UN9 Q9D1H5 uc008uor.1 uc008uor.2 uc008uor.3 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37) (PubMed:23289710). Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA) (By similarity). TRIT1 is therefore required for selenoprotein expression (PubMed:23289710). Reaction=adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA; Xref=Rhea:RHEA:26482, Rhea:RHEA-COMP:10162, Rhea:RHEA-COMP:10375, ChEBI:CHEBI:33019, ChEBI:CHEBI:57623, ChEBI:CHEBI:74411, ChEBI:CHEBI:74415; EC=2.5.1.75; Evidence=; [Isoform 1]: Mitochondrion [Isoform 2]: Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80UN9-1; Sequence=Displayed; Name=2; IsoId=Q80UN9-2; Sequence=VSP_010722; Belongs to the IPP transferase family. nucleotide binding ATP binding nucleus cytoplasm mitochondrion tRNA modification tRNA processing transferase activity metal ion binding tRNA dimethylallyltransferase activity uc008uor.1 uc008uor.2 uc008uor.3 
ENSMUST00000102650.10 Akap10 ENSMUST00000102650.10 A kinase anchor protein 10 (from RefSeq NM_019921.3) AKA10_MOUSE ENSMUST00000102650.1 ENSMUST00000102650.2 ENSMUST00000102650.3 ENSMUST00000102650.4 ENSMUST00000102650.5 ENSMUST00000102650.6 ENSMUST00000102650.7 ENSMUST00000102650.8 ENSMUST00000102650.9 NM_019921 O88845 Q5SUB5 Q5SUB7 Q7TPE7 Q8BQL6 uc007jii.1 uc007jii.2 uc007jii.3 uc007jii.4 This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. It has been reported that this protein is important for maintaining heart rate and myocardial contractility through its targeting of protein kinase A. In mouse, defects of this gene lead to cardiac arrhythmias and premature death. In humans, polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK049399.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 11248059; reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G- alpha proteins, providing a link between the signaling machinery and the downstream kinase. Mitochondrion Membrane Cytoplasm Note=Predominantly mitochondrial but also membrane associated and cytoplasmic. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O88845-1; Sequence=Displayed; Name=2; IsoId=O88845-2; Sequence=VSP_014873, VSP_014876; Name=3; IsoId=O88845-3; Sequence=VSP_014874, VSP_014875; Highly expressed in testis, kidney and lung, followed by brain, skeletal muscle, liver, spleen and heart. Also expressed in brown adipose tissue and pancreas. RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. Sequence=AAC61898.1; Type=Frameshift; Evidence=; Sequence=AAH54105.1; Type=Erroneous initiation; Evidence=; cytoplasm mitochondrion cytosol plasma membrane protein localization membrane macromolecular complex protein kinase A binding uc007jii.1 uc007jii.2 uc007jii.3 uc007jii.4 
ENSMUST00000102655.10 Pde1a ENSMUST00000102655.10 phosphodiesterase 1A, calmodulin-dependent, transcript variant 2 (from RefSeq NM_016744.5) E9Q6V1 ENSMUST00000102655.1 ENSMUST00000102655.2 ENSMUST00000102655.3 ENSMUST00000102655.4 ENSMUST00000102655.5 ENSMUST00000102655.6 ENSMUST00000102655.7 ENSMUST00000102655.8 ENSMUST00000102655.9 NM_016744 O35388 PDE1A_MOUSE Pde1a Q5I7S8 Q61481 Q8BRR9 Q9JLL9 uc012bxz.1 uc012bxz.2 uc012bxz.3 Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Reaction=a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'- phosphate + H(+); Xref=Rhea:RHEA:14653, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57867, ChEBI:CHEBI:58464; EC=3.1.4.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14654; Evidence=; [Isoform 2]: Reaction=a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'- phosphate + H(+); Xref=Rhea:RHEA:14653, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57867, ChEBI:CHEBI:58464; EC=3.1.4.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14654; Evidence=; Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, ChEBI:CHEBI:58115; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16958; Evidence=; Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278; Evidence=; [Isoform 2]: Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, ChEBI:CHEBI:58115; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16958; Evidence=; [Isoform 2]: Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions. ; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 2 has a preference for magnesium ions. ; Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+). [Isoform 2]: Activated by the binding of calmodulin in the presence of Ca(2+). Homodimer (By similarity). Interacts with YWHAZ (By similarity). [Isoform 2]: Cell projection, cilium, flagellum Note=Concentrates in the tail of mature sperm. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Pde1a_v2 , mmPDE1A2 ; IsoId=Q61481-4; Sequence=Displayed; Name=2; Synonyms=Pde1a_v7 , mmPDE1A7 ; IsoId=Q61481-5; Sequence=VSP_060311, VSP_060313, VSP_060314; Name=3; Synonyms=Pde1a_v9 , mmPDE1A9 ; IsoId=Q61481-6; Sequence=VSP_060311, VSP_060312, VSP_060315; Name=4; Synonyms=PDE1A1, Pde1a_v1 ; IsoId=Q61481-2; Sequence=VSP_004551; Expressed in brain, kidney and testis. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. Sequence=AAB03319.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; 3',5'-cyclic-nucleotide phosphodiesterase activity calmodulin-dependent cyclic-nucleotide phosphodiesterase activity calmodulin binding nucleus cytoplasm signal transduction phosphoric diester hydrolase activity hydrolase activity regulation of smooth muscle cell apoptotic process neuronal cell body cGMP catabolic process metal ion binding calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity regulation of smooth muscle cell proliferation uc012bxz.1 uc012bxz.2 uc012bxz.3 
ENSMUST00000102656.4 Foxo6 ENSMUST00000102656.4 forkhead box O6 (from RefSeq NM_194060.1) ENSMUST00000102656.1 ENSMUST00000102656.2 ENSMUST00000102656.3 FOXO6_MOUSE NM_194060 Q70KY4 uc008unc.1 uc008unc.2 uc008unc.3 Transcriptional activator. Cytoplasm Nucleus Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors. Expressed in brain in areas of the nucleus accumbens, cingulate cortex, parts of the amygdala and in the hippocampus. Expressed in developing brain in a specific temporal and spatial pattern. Phosphorylation of Ser-184 is be important in regulating the transacriptional activity. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter memory transcription factor binding insulin receptor signaling pathway glucose homeostasis sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter positive regulation of dendritic spine development uc008unc.1 uc008unc.2 uc008unc.3 
ENSMUST00000102657.10 B9d1 ENSMUST00000102657.10 B9 protein domain 1, transcript variant 1 (from RefSeq NM_013717.3) B9D1_MOUSE ENSMUST00000102657.1 ENSMUST00000102657.2 ENSMUST00000102657.3 ENSMUST00000102657.4 ENSMUST00000102657.5 ENSMUST00000102657.6 ENSMUST00000102657.7 ENSMUST00000102657.8 ENSMUST00000102657.9 Eppb9 NM_013717 Q9R1S0 uc007jhu.1 uc007jhu.2 uc007jhu.3 Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling. Part of the tectonic-like complex (also named B9 complex). Q9R1S0; Q3UK10: B9d2; NbExp=5; IntAct=EBI-5652050, EBI-5652008; Q9R1S0; Q5SW45: Mks1; NbExp=4; IntAct=EBI-5652050, EBI-4281059; Cytoplasm, cytoskeleton, cilium basal body Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Specifically or prominently expressed in mouse blastocysts compared to 4-cell stage embryos. Mice display impaired cilia formation associated with renal cystic dysplasia, as well as ductal plate malformation of the liver and polydactyly. Additional phenotypes, occurring at varying frequencies, include randomized heart looping, holoprosencephaly, microphthalmia, cleft palate, ventricular septal defect and thinning of the myocardial wall. Depending on their genetic background, mutant mice die between 14.5 dpc and P1. Belongs to the B9D family. in utero embryonic development vasculature development protein binding cytoplasm centrosome cytoskeleton cilium smoothened signaling pathway hedgehog receptor activity membrane cell projection organization regulation of protein localization ciliary transition zone MKS complex ciliary basal body embryonic digit morphogenesis cell projection camera-type eye development cilium assembly neuroepithelial cell differentiation uc007jhu.1 uc007jhu.2 uc007jhu.3 
ENSMUST00000102659.2 Sestd1 ENSMUST00000102659.2 SEC14 and spectrin domains 1 (from RefSeq NM_175465.6) ENSMUST00000102659.1 NM_175465 Q3TLJ1 Q80UK0 Q810W3 Q8CI09 SESD1_MOUSE uc008kfx.1 uc008kfx.2 uc008kfx.3 uc008kfx.4 uc008kfx.5 May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1 (By similarity). Interacts (via the spectrin 1 repeat) with TRPC4 and TRPC5 (via CIRB domain). Interacts with CTNNB1. Belongs to the SOLO family. phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-5-phosphate binding phosphatidylinositol-3-phosphate binding calcium channel complex phosphatidylinositol-3,4-bisphosphate binding intermediate filament cytoskeleton phosphatidylinositol-4-phosphate binding phosphatidic acid binding phosphatidylinositol-3,5-bisphosphate binding negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel uc008kfx.1 uc008kfx.2 uc008kfx.3 uc008kfx.4 uc008kfx.5 
ENSMUST00000102661.4 Rnf112 ENSMUST00000102661.4 ring finger protein 112, transcript variant 2 (from RefSeq NM_001291024.1) Bfp ENSMUST00000102661.1 ENSMUST00000102661.2 ENSMUST00000102661.3 NM_001291024 Q3TNS6 Q5NCN2 Q8JZT5 Q96DY5 Q9Z328 RN112_MOUSE Znf179 uc007jhl.1 uc007jhl.2 uc007jhl.3 uc007jhl.4 E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins (PubMed:21566658, PubMed:28684796). Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage (PubMed:27918959, PubMed:26792191, PubMed:26951452). Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (PubMed:26212327). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Self-associates (PubMed:26212327). Interacts with SP1 in an oxidative stress-regulated manner (PubMed:27918959). Interacts with SIGMAR1 in an oxidative stress-regulated manner (PubMed:26792191). Interacts with ZBTB16 (via C2H2-type zinc finger domains 1 and 2) (PubMed:24359566). Membrane ; Multi- pass membrane protein Membrane ; Peripheral membrane protein Cytoplasm cleus cleus, nuclear body Nucleus, nucleoplasm Endosome Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Postsynaptic density Perikaryon Cell projection, neuron projection Note=Predominantly in the nucleus, but some amounts were also found in the cytoplasm (PubMed:9806830, PubMed:24359566). Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus (PubMed:27918959). Recruited to nuclear bodies via its interaction with ZBTB16 (PubMed:24359566). Localizes to the cell soma and neuritis and only slightly to the nucleus in the neurons of most brain areas (PubMed:26951452). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96DY5-1; Sequence=Displayed; Name=2; IsoId=Q96DY5-2; Sequence=VSP_042392; Name=3; IsoId=Q96DY5-3; Sequence=VSP_042393; Expressed in most of the brain areas, including cortex, striatum, hippocampus, thalamus, and cerebellum (at protein level). Expressed in lateral amygdaloid nucleus, and ventromedial hypothalamus. Also expressed strongly in the marginal zone of brain vesicles, optic stalk, and cartilage primordium. Up-regulated by traumatic brain injury and hydrogen peroxide (at protein level). Auto-ubiquitinated. Embryos exhibit blood vascular defects and die in utero. The survivors manifest growth retardation as indicated by smaller size and a reduced weight, and display impairment of brain functions including motor balance, and spatial learning and memory (PubMed:26951452). Mice exhibit a reduction in the size of brains, reduced dendritic spine density, impaired synaptic transmission and reduced levels of antioxidant enzymes in the hippocampus (PubMed:26792191, PubMed:26212327). Knockdown of RNF112 diminishes neuronal differentiation, glial differentiation and dendritic arborization in primary cerebellar granule cells (PubMed:28684796, PubMed:21566658). Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily. Sequence=BAA34180.1; Type=Frameshift; Evidence=; nucleotide binding GTPase activity protein binding GTP binding nucleus nucleoplasm cytoplasm endosome plasma membrane endoplasmic reticulum organization cell cycle arrest nervous system development synaptic vesicle postsynaptic density membrane integral component of membrane protein ubiquitination nuclear body transferase activity extrinsic component of membrane cell junction neuron differentiation cytoplasmic vesicle response to hydroperoxide cell death in response to oxidative stress cell death in response to hydrogen peroxide protein self-association cell body synapse postsynaptic membrane positive regulation of neuron differentiation positive regulation of glial cell differentiation metal ion binding protein homooligomerization protein autoubiquitination ubiquitin protein ligase activity positive regulation of cell cycle arrest embryonic brain development uc007jhl.1 uc007jhl.2 uc007jhl.3 uc007jhl.4 
ENSMUST00000102665.11 Mog ENSMUST00000102665.11 myelin oligodendrocyte glycoprotein (from RefSeq NM_010814.2) ENSMUST00000102665.1 ENSMUST00000102665.10 ENSMUST00000102665.2 ENSMUST00000102665.3 ENSMUST00000102665.4 ENSMUST00000102665.5 ENSMUST00000102665.6 ENSMUST00000102665.7 ENSMUST00000102665.8 ENSMUST00000102665.9 Mog NM_010814 Q3UY21 Q3UY21_MOUSE uc008clx.1 uc008clx.2 uc008clx.3 Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. Homodimer. Membrane ; Multi- pass membrane protein Belongs to the immunoglobulin superfamily. BTN/MOG family. cell adhesion membrane integral component of membrane uc008clx.1 uc008clx.2 uc008clx.3 
ENSMUST00000102672.5 Nfe2l2 ENSMUST00000102672.5 nuclear factor, erythroid derived 2, like 2, transcript variant 1 (from RefSeq NM_010902.5) ENSMUST00000102672.1 ENSMUST00000102672.2 ENSMUST00000102672.3 ENSMUST00000102672.4 NF2L2_MOUSE NM_010902 Nfe2l2 Nrf2 Q3UQK0 Q60795 uc008keq.1 uc008keq.2 uc008keq.3 uc008keq.4 This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. [provided by RefSeq, Sep 2015]. Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:9240432, PubMed:9887101, PubMed:12032331, PubMed:14517554, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:15282312, PubMed:15367669, PubMed:15581590). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:12032331). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20421418, PubMed:20173742). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (By similarity). Also plays an important role in the regulation of the innate immune response. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88- dependent and -independent and TNF-alpha signaling (PubMed:16585964). Suppresses macrophage inflammatory response by blocking pro- inflammatory cytokine transcription and the induction of IL6 (PubMed:27211851). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the Nrf2-binding motif and reactive oxygen species level (PubMed:27211851). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (By similarity). Heterodimer; heterodimerizes with small Maf proteins (PubMed:9240432). Interacts (via the bZIP domain) with MAFG and MAFK; required for binding to antioxidant response elements (AREs) on DNA (PubMed:9240432, PubMed:31398338). Interacts with KEAP1; the interaction is direct and promotes ubiquitination by the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:9887101, PubMed:15282312, PubMed:15367669, PubMed:15581590, PubMed:16790436, PubMed:16581765, PubMed:16507366). Forms a ternary complex with PGAM5 and KEAP1 (By similarity). Interacts with EEF1D at heat shock promoter elements (HSE) (By similarity). Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1 (PubMed:11583586). Interacts with CHD6; involved in activation of the transcription (By similarity). Interacts with ESRRB; represses NFE2L2 transcriptional activity (PubMed:17920186). Interacts with MOTS-c, a peptide produced by the mitochondrially encoded 12S rRNA MT-RNR1; the interaction occurs in the nucleus following metabolic stress (By similarity). Q60795; Q8BWG8: Arrb1; NbExp=4; IntAct=EBI-642563, EBI-641778; Q60795; Q9Z2X8: Keap1; NbExp=23; IntAct=EBI-642563, EBI-647110; Q60795; P97474: Pitx2; NbExp=2; IntAct=EBI-642563, EBI-1175125; Cytoplasm, cytosol cleus Note=Cytosolic under unstressed conditions: ubiquitinated and degraded by the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:15367669). Translocates into the nucleus upon induction by electrophilic agents that inactivate the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:14517554). Widely expressed. Highest expression in liver, skeletal muscle, luminal cells of the stomach and intestine, lining of the bronchi and alveoli, and in renal tubules; followed by heart, spleen, testis and brain. The ETGE motif, and to a lower extent the DLG motif, mediate interaction with KEAP1. Ubiquitinated in the cytoplasm by the BCR(KEAP1) E3 ubiquitin ligase complex leading to its degradation (PubMed:15282312, PubMed:15367669, PubMed:15581590, PubMed:16790436, PubMed:20421418). In response to oxidative stress, electrophile metabolites, such as sulforaphane, modify KEAP1, leading to inhibit activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and activity (PubMed:15367669). In response to autophagy, the BCR(KEAP1) complex is inactivated (PubMed:20421418). Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus. Acetylation at Lys-588 and Lys-591 increases nuclear localization whereas deacetylation by SIRT1 enhances cytoplasmic presence. Glycation impairs transcription factor activity by preventing heterodimerization with small Maf proteins (PubMed:31398338). Deglycation by FN3K restores activity (PubMed:31398338). Mice are viable and fertile but have low and uninducible phase 2 detoxifying enzymes, are much more susceptible to carcinogens and the toxicity of oxygen and electrophiles and cannot be protected by inducers (PubMed:9240432, PubMed:11248092, PubMed:12032331). Mutant mice show an increased mortality during LPS and cecal ligation and puncture-induced septic shock compared to wild- types. They show greater pulmonary inflammation and greater TNF secretion upon LPS administration (PubMed:16585964). Mice lacking both Nfe2l2/Nrf2 and Keap1 reverse the hyperkeratosis phenotype observed in Keap1 knockout: mice and are healthy and viable in normal conditions (PubMed:14517554). Mice lacking both Nfe2l1 and Nfe2l2 die early between embryonic days 9 and 10 and exhibit extensive apoptosis due to marked oxidative stress in cells that is indicated by elevated intracellular reactive oxygen species levels and cell death (PubMed:12968018). Belongs to the bZIP family. CNC subfamily. chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm Golgi apparatus centrosome cytosol plasma membrane regulation of transcription, DNA-templated inflammatory response aging transcription factor binding proteasomal ubiquitin-independent protein catabolic process positive regulation of gene expression negative regulation of cardiac muscle cell apoptotic process positive regulation of neuron projection development protein ubiquitination protein domain specific binding positive regulation of blood coagulation endoplasmic reticulum unfolded protein response protein-DNA complex cellular response to oxidative stress response to endoplasmic reticulum stress cellular response to drug positive regulation of transcription from RNA polymerase II promoter in response to stress positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress PERK-mediated unfolded protein response cellular response to glucose starvation proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of blood vessel endothelial cell migration sequence-specific DNA binding cell redox homeostasis positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development aflatoxin catabolic process positive regulation of glucose import protein heterodimerization activity negative regulation of cell death regulation of transcription from RNA polymerase II promoter in response to copper ion positive regulation of transcription from RNA polymerase II promoter in response to hypoxia cellular response to hydrogen peroxide cellular response to tumor necrosis factor cellular response to hypoxia cellular response to fluid shear stress cellular response to laminar fluid shear stress negative regulation of hematopoietic stem cell differentiation negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced cell death positive regulation of glutathione biosynthetic process cellular response to angiotensin negative regulation of vascular associated smooth muscle cell migration regulation of removal of superoxide radicals negative regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process uc008keq.1 uc008keq.2 uc008keq.3 uc008keq.4 
ENSMUST00000102675.10 H2-T3 ENSMUST00000102675.10 histocompatibility 2, T region locus 3 (from RefSeq NM_008208.4) ENSMUST00000102675.1 ENSMUST00000102675.2 ENSMUST00000102675.3 ENSMUST00000102675.4 ENSMUST00000102675.5 ENSMUST00000102675.6 ENSMUST00000102675.7 ENSMUST00000102675.8 ENSMUST00000102675.9 H2-T3 NM_008208 Q05A75 Q05A75_MOUSE uc008ckm.1 uc008ckm.2 uc008ckm.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. membrane integral component of membrane uc008ckm.1 uc008ckm.2 uc008ckm.3 
ENSMUST00000102678.5 H2-T23 ENSMUST00000102678.5 histocompatibility 2, T region locus 23 (from RefSeq NM_010398.3) ENSMUST00000102678.1 ENSMUST00000102678.2 ENSMUST00000102678.3 ENSMUST00000102678.4 H2-T23 NM_010398 Q3V014 Q3V014_MOUSE uc008cjr.1 uc008cjr.2 uc008cjr.3 Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. membrane integral component of membrane uc008cjr.1 uc008cjr.2 uc008cjr.3 
ENSMUST00000102683.11 Tom1l2 ENSMUST00000102683.11 target of myb1-like 2 (chicken), transcript variant 1 (from RefSeq NM_153080.3) A0JP66 ENSMUST00000102683.1 ENSMUST00000102683.10 ENSMUST00000102683.2 ENSMUST00000102683.3 ENSMUST00000102683.4 ENSMUST00000102683.5 ENSMUST00000102683.6 ENSMUST00000102683.7 ENSMUST00000102683.8 ENSMUST00000102683.9 NM_153080 Q5SRX1 Q5SRX7 Q5SRY0 Q6P5D7 Q8C6J0 Q8C935 Q8CB51 Q8R4H1 TM1L2_MOUSE uc007jfq.1 uc007jfq.2 uc007jfq.3 Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (By similarity). May also play a role in recruiting clathrin to endosomes (By similarity). May regulate growth factor-induced mitogenic signaling (By similarity). Interacts with clathrin, SRC and TOLLIP (By similarity). Interacts with MYO6 (By similarity). Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q5SRX1-1; Sequence=Displayed; Name=2; IsoId=Q5SRX1-2; Sequence=VSP_023396; Name=3; IsoId=Q5SRX1-3; Sequence=VSP_023397, VSP_023398; Name=4; IsoId=Q5SRX1-4; Sequence=VSP_023395, VSP_023399; Name=5; IsoId=Q5SRX1-5; Sequence=VSP_023393, VSP_023394; Ubiquitously expressed. Splicing pattern displays tissue specific variation. The GAT domain mediates interaction with TOLLIP. [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the TOM1 family. cell intracellular protein transport signal transduction protein transport protein kinase binding clathrin binding negative regulation of mitotic nuclear division uc007jfq.1 uc007jfq.2 uc007jfq.3 
ENSMUST00000102687.4 Dmap1 ENSMUST00000102687.4 DNA methyltransferase 1-associated protein 1, transcript variant 1 (from RefSeq NM_023178.3) DMAP1_MOUSE ENSMUST00000102687.1 ENSMUST00000102687.2 ENSMUST00000102687.3 Mmtr NM_023178 Q99LM0 Q9CSS9 Q9DB33 Q9JI44 uc008uiw.1 uc008uiw.2 uc008uiw.3 Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity (By similarity). Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. DMAP1 also forms a complex with DNMT1 and HDAC2. Throughout S phase it interacts directly with the N-terminus of DNMT1, which serves to recruit DMAP1 to replication foci. DMAP1 interacts with ING1, a component of the mSIN3A transcription repressor complex, although this interaction is not required for recruitment of ING1 to heterochromatin. Interacts directly with the transcriptional corepressor TSG101. Interacts with URI1 (By similarity). Interacts with the pro-apoptotic protein DAXX. Nucleus. Cytoplasm Note=Targeted to replication foci throughout S phase by DNMT1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JI44-1; Sequence=Displayed; Name=2; IsoId=Q9JI44-2; Sequence=VSP_003850, VSP_003851; [Isoform 2]: May be due to intron retention. negative regulation of transcription from RNA polymerase II promoter Swr1 complex RNA polymerase II repressing transcription factor binding transcription corepressor activity protein binding nucleus nucleoplasm replication fork cytoplasm cytosol DNA repair chromatin organization chromatin remodeling NuA4 histone acetyltransferase complex regulation of growth positive regulation of protein import into nucleus histone exchange histone H4 acetylation histone H2A acetylation response to ethanol negative regulation of transcription, DNA-templated uc008uiw.1 uc008uiw.2 uc008uiw.3 
ENSMUST00000102689.10 Sp3 ENSMUST00000102689.10 trans-acting transcription factor 3, transcript variant 2 (from RefSeq NM_001098425.1) A2AQK9 ENSMUST00000102689.1 ENSMUST00000102689.2 ENSMUST00000102689.3 ENSMUST00000102689.4 ENSMUST00000102689.5 ENSMUST00000102689.6 ENSMUST00000102689.7 ENSMUST00000102689.8 ENSMUST00000102689.9 NM_001098425 O70494 Q68FF2 Q8CF64 Q8K378 SP3_MOUSE uc008kcc.1 uc008kcc.2 uc008kcc.3 uc008kcc.4 uc008kcc.5 This gene product belongs to a family of Sp1 related transcription factors, which regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses transcription of numerous genes. Alternative splicing results in transcript variants encoding different isoforms, and one variant initiates translation from a non-AUG (AUA) codon. [provided by RefSeq, Jul 2008]. Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping (By similarity). Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts with HDAC1; the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with HDAC2 (preferably the CK2-phosphorylated form); the interaction deacetylates SP3 and regulates its transcriptional activity. Ceramides can also regulate acetylation/deacetylation events through altering the interaction of HDAC with SP3. Interacts with MEIS2 isoform Meis2D and PBX1 isoform PBX1a (By similarity). O70494; Q9Z2D6: Mecp2; NbExp=2; IntAct=EBI-643514, EBI-1188816; Nucleus. Nucleus, PML body Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O70494-1; Sequence=Displayed; Name=2; IsoId=O70494-2; Sequence=VSP_016783; Name=3; IsoId=O70494-3; Sequence=VSP_016782, VSP_016784; The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at Lys-553 also control transcriptional activity (By similarity). Sumoylated on all isoforms. Sumoylated on 2 sites in longer isoforms with Lys-553 being the major site. Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear bodies. Sumoylation on Lys-553 represses the transactivation activity, except for the largest isoform which has little effect on transactivation. Alternate sumoylation and acetylation at Lys-553 also control transcriptional activity (By similarity). Belongs to the Sp1 C2H2-type zinc-finger protein family. Sequence=AAH27797.2; Type=Erroneous initiation; Evidence=; Sequence=BAE21310.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding ossification in utero embryonic development natural killer cell differentiation trophectodermal cell differentiation liver development embryonic placenta development nucleic acid binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter PML body transcriptional repressor complex B cell differentiation T cell differentiation erythrocyte differentiation megakaryocyte differentiation monocyte differentiation lung development granulocyte differentiation protein-DNA complex enucleate erythrocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding embryonic camera-type eye morphogenesis embryonic skeletal system development embryonic process involved in female pregnancy definitive hemopoiesis uc008kcc.1 uc008kcc.2 uc008kcc.3 uc008kcc.4 uc008kcc.5 
ENSMUST00000102691.11 Cdca7 ENSMUST00000102691.11 cell division cycle associated 7, transcript variant 1 (from RefSeq NM_025866.4) CDCA7_MOUSE ENSMUST00000102691.1 ENSMUST00000102691.10 ENSMUST00000102691.2 ENSMUST00000102691.3 ENSMUST00000102691.4 ENSMUST00000102691.5 ENSMUST00000102691.6 ENSMUST00000102691.7 ENSMUST00000102691.8 ENSMUST00000102691.9 NM_025866 Q3TIS1 Q3U511 Q6NZE5 Q8C1A0 Q9D0M2 uc008kbx.1 uc008kbx.2 uc008kbx.3 Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity). Interacts with MYC (via C-terminus), YWHAE and YWHAZ. Nucleus Cytoplasm Note=Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-170 (By similarity). Phosphorylation at Thr-170 promotes interaction with YWHAE and YWHAZ, dissociation from MYC and sequestration in the cytoplasm. Transgenic mice overexpress Cdca7 in both T- and B-cell compartments. At 1 year of age, they exhibit elevated incidence of lymphomas, significant increased frequency of solid tumors and a 2-fold increased risk of lymphoid malignancies compared to their littermates. molecular_function nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated apoptotic process regulation of cell proliferation uc008kbx.1 uc008kbx.2 uc008kbx.3 
ENSMUST00000102694.4 Ptgfrn ENSMUST00000102694.4 prostaglandin F2 receptor negative regulator (from RefSeq NM_011197.3) ENSMUST00000102694.1 ENSMUST00000102694.2 ENSMUST00000102694.3 FPRP_MOUSE Fprp NM_011197 Q5SRA8 Q9WV91 uc008qre.1 uc008qre.2 uc008qre.3 Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration. Interacts with CD9 and CD81 (By similarity). Part of a complex composed of CD9, CD81 and IGSF8 (PubMed:23575678). Also seems to interact with CD63, CD82 and CD151 (By similarity). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Golgi apparatus, trans-Golgi network membrane ; Single-pass type I membrane protein Expressed in myoblasts (at protein level). protein binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus myoblast fusion involved in skeletal muscle regeneration membrane integral component of membrane lipid particle organization uc008qre.1 uc008qre.2 uc008qre.3 
ENSMUST00000102695.4 Nt5m ENSMUST00000102695.4 5',3'-nucleotidase, mitochondrial, transcript variant 10 (from RefSeq NR_184731.1) Dnt2 ENSMUST00000102695.1 ENSMUST00000102695.2 ENSMUST00000102695.3 NR_184731 NT5M_MOUSE Q8VCE6 uc007jfd.1 uc007jfd.2 Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Homodimer. Mitochondrion Belongs to the 5'(3')-deoxyribonucleotidase family. nucleotide binding mitochondrion 5'-nucleotidase activity nucleotide metabolic process deoxyribonucleotide catabolic process dephosphorylation hydrolase activity dUMP catabolic process metal ion binding uc007jfd.1 uc007jfd.2 
ENSMUST00000102696.5 Rps8 ENSMUST00000102696.5 ribosomal protein S8 (from RefSeq NM_009098.2) ENSMUST00000102696.1 ENSMUST00000102696.2 ENSMUST00000102696.3 ENSMUST00000102696.4 NM_009098 Q497E9 Q497E9_MOUSE Rps8 uc008uic.1 uc008uic.2 uc008uic.3 Belongs to the eukaryotic ribosomal protein eS8 family. structural constituent of ribosome ribosome translation uc008uic.1 uc008uic.2 uc008uic.3 
ENSMUST00000102697.10 Flcn ENSMUST00000102697.10 folliculin, transcript variant 2 (from RefSeq NM_146018.2) Bhd ENSMUST00000102697.1 ENSMUST00000102697.2 ENSMUST00000102697.3 ENSMUST00000102697.4 ENSMUST00000102697.5 ENSMUST00000102697.6 ENSMUST00000102697.7 ENSMUST00000102697.8 ENSMUST00000102697.9 FLCN_MOUSE Flcn NM_146018 Q3U4U8 Q3UFZ1 Q5SWZ2 Q5SX01 Q5SX02 Q8CAC0 Q8QZS3 uc007jew.1 uc007jew.2 uc007jew.3 uc007jew.4 Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:23582324, PubMed:27913603, PubMed:32612235). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:23582324, PubMed:27913603, PubMed:32612235). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (By similarity). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (By similarity). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:27913603, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (By similarity). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR- independent TFE3 inactivation (PubMed:30595499). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (PubMed:27913603). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (By similarity). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (By similarity). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (By similarity). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (By similarity). GTPase-activating activity is inhibited in the folliculin complex (LFC), which stabilizes the GDP-bound state of RagA/RRAGA (or RagB/RRAGB), because Arg-164 is located far from the RagC/RRAGC or RagD/RRAGD nucleotide pocket (By similarity). Disassembly of the LFC complex upon amino acid restimulation liberates the GTPase- activating activity (By similarity). Interacts (via C-terminus) with FNIP1 or FNIP2 (via C- terminus). Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator. Interaction with FNIP1 or FNIP2 mediates indirect interaction with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK). Interacts with HSP90AA1 in the presence of FNIP1. Interacts with HSP70, STUB1, CDC37, AHSA1, CCT2, STIP1, PTGES3 and PPP5C (By similarity). Interacts with GABARAP; interaction takes place in the presence of FNIP1 and/or FNIP2 (By similarity). Interacts with RILP; the interaction is direct and promotes association between RILP and RAB34 (By similarity). Interacts with KIF3A and KIF3B (By similarity). Interacts with lactate dehydrogenase LDHA, but not LDHB; the interaction is direct, may preferentially bind LDHA dimers rather than tetramers, and regulates LDHA activity, acting as an uncompetitive inhibitor. Q8QZS3; Q68FD7: Fnip1; NbExp=3; IntAct=EBI-6911093, EBI-6911068; Lysosome membrane Cytoplasm, cytosol Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Nucleus Note=Localizes to lysosome membrane in amino acid-depleted conditions and relocalizes to the cytosol upon refeeding. Colocalizes with FNIP1 and FNIP2 in the cytoplasm. Also localizes to motile and non-motile cilia, centrosomes and the mitotic spindle. Highly expressed in adult heart, pancreas, and prostate with moderate expression in adult brain, kidney, liver, adipose tissue and lung. Expressed throughout embryogenesis (PubMed:19850877). At 5.5 dpc, expression is restricted to extraembryonic tissues; by 6.5 dpc, expressed in both embryonic and extraembryonic tissues (PubMed:19850877). Strong expression is observed in certain tissues including neural ectoderm, headfold and limb buds, while it is weakly expressed in the surrounding endoderm and heart (PubMed:19850877). Phosphorylation by ULK1 modulates the interaction with GABARAP and is required to regulate autophagy. Embryonic lethality at 5.5-6.5 dpc, showing defects in the visceral endoderm (PubMed:18974783, PubMed:19850877). Heterozygous knockout mice appear normal at birth but develop kidney cysts and solid tumors as they age, probably caused by activation of the mTOR pathway (PubMed:19850877). Conditional deletion in kidney leads to development of polycystic kidneys and renal neoplasia, caused by activation of the mTOR pathway (PubMed:18182616, PubMed:18974783, PubMed:32612235). Mice lacking Tfeb and Flcn in the kidney do not show any abnormality in the kidney, suggesting that the kidney phenotype observed in Flcn knockout mice is due to constitutive activation of Tfeb (PubMed:32612235). Conditional deletion in heart causes cardiac hypertrophy with deregulated energy homeostasis leading to dilated cardiomyopathy: defects are caused by mTORC1 up-regulation (PubMed:24908670). Conditional deletion in adipose tissue leads to browning of white adipose tissue (WAT) caused by deregulation of mTORC1 that relieves cytoplasmic retention of Tfe3, leading to direct induction of the Ppargc1b/PGC-1 transcriptional coactivators, drivers of mitochondrial biogenesis and the browning program (PubMed:27913603). Belongs to the folliculin family. Sequence=BAC30240.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter in utero embryonic development regulation of protein phosphorylation positive regulation of protein phosphorylation guanyl-nucleotide exchange factor activity protein binding nucleus cytoplasm cytosol plasma membrane cell-cell junction assembly positive regulation of autophagy negative regulation of gene expression negative regulation of mitochondrion organization negative regulation of angiogenesis hemopoiesis negative regulation of cell growth negative regulation of cell migration midbody positive regulation of transforming growth factor beta receptor signaling pathway TOR signaling regulation of TOR signaling negative regulation of TOR signaling positive regulation of TOR signaling regulation of cytokinesis negative regulation of Rho protein signal transduction regulation of histone acetylation positive regulation of GTPase activity cell-cell contact zone macromolecular complex binding positive regulation of cell adhesion negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade energy homeostasis negative regulation of protein localization to nucleus negative regulation of cell proliferation involved in kidney development negative regulation of cellular respiration negative regulation of mitochondrial DNA metabolic process negative regulation of muscle tissue development negative regulation of post-translational protein modification negative regulation of TORC2 signaling positive regulation of TORC1 signaling regulation of pro-B cell differentiation negative regulation of ATP biosynthetic process positive regulation of intrinsic apoptotic signaling pathway GTPase activator activity uc007jew.1 uc007jew.2 uc007jew.3 uc007jew.4 
ENSMUST00000102699.8 Mutyh ENSMUST00000102699.8 mutY DNA glycosylase, transcript variant 2 (from RefSeq NM_133250.2) A2AGE3 ENSMUST00000102699.1 ENSMUST00000102699.2 ENSMUST00000102699.3 ENSMUST00000102699.4 ENSMUST00000102699.5 ENSMUST00000102699.6 ENSMUST00000102699.7 MUTYH_MOUSE Myh NM_133250 Q99P21 uc012djn.1 uc012djn.2 uc012djn.3 Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. Reaction=Hydrolyzes free adenine bases from 7,8-dihydro-8- oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.; EC=3.2.2.31; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand. ; Nucleus Mitochondrion Expressed in heart, lung, liver, intestine, brain and thymus. Belongs to the Nth/MutY family. purine-specific mismatch base pair DNA N-glycosylase activity DNA binding catalytic activity nucleus nucleoplasm mitochondrion DNA repair base-excision repair mismatch repair cellular response to DNA damage stimulus response to oxidative stress metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds DNA N-glycosylase activity oxidized purine DNA binding MutSalpha complex binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity adenine/guanine mispair binding metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding uc012djn.1 uc012djn.2 uc012djn.3 
ENSMUST00000102703.2 Zfp39 ENSMUST00000102703.2 zinc finger protein 39 (from RefSeq NM_011758.2) ENSMUST00000102703.1 NM_011758 Q02525 Q2YDX7 Q5NC60 Q8BL91 ZFP39_MOUSE Zfp-39 uc007jcn.1 uc007jcn.2 A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis. Nucleus. Predominantly in the spermatocytes and spermatids of testes. First detected between 2 and 3 weeks after birth, in parallel with the onset and progression of meiosis. Sequence=BAA01479.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development spermatogenesis cell differentiation metal ion binding uc007jcn.1 uc007jcn.2 
ENSMUST00000102705.10 Rad54l ENSMUST00000102705.10 RAD54 like (S. cerevisiae), transcript variant 8 (from RefSeq NM_001424848.1) ENSMUST00000102705.1 ENSMUST00000102705.2 ENSMUST00000102705.3 ENSMUST00000102705.4 ENSMUST00000102705.5 ENSMUST00000102705.6 ENSMUST00000102705.7 ENSMUST00000102705.8 ENSMUST00000102705.9 NM_001424848 P70270 Q8BSR5 Q8C2C4 Q8K3D4 RAD54_MOUSE Rad54 uc008ugd.1 uc008ugd.2 uc008ugd.3 uc008ugd.4 Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Plays also an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). Deficiency also resulted in an increased frequency of end- to-end chromosome fusions involving telomeres compared to the controls, suggesting a putative role in telomere capping. Non-homologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. LIG4 and RAD54L cooperate to support cellular proliferation, repair spontaneous DSBs, and prevent chromosome and single chromatid aberrations (PubMed:10209103, PubMed:10757799, PubMed:12218123, PubMed:12531026, PubMed:12548566, PubMed:12897131, PubMed:15175260, PubMed:9108475). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Homohexamer (By similarity). Interacts (via N-terminus) with RAD51 (By similarity). Interacts with NAP1L1 (By similarity). Interacts with BRD9; this interaction orchestrates RAD51-RAD54 complex formation (By similarity). Nucleus Hardly detectable in most tissues. Dramatically increased in thymus, spleen and testis. Acetylated. Acetylation promotes interaction with BRD9, and subsequently with RAD54, which is essential for homologous recombination (HR). Phosphorylated. Phosphorylation at Ser-572 by NEK1 specifically in G2 phase allows efficient removal of RAD51 filaments from DNA. The nucleus of a mouse embryonic stem (ES) cell contains on average 2.4 x 10(5) molecules. Belongs to the SNF2/RAD54 helicase family. nucleotide binding double-strand break repair via homologous recombination DNA strand renaturation DNA binding helicase activity ATP binding nucleus nucleoplasm DNA repair double-strand break repair cellular response to DNA damage stimulus reciprocal meiotic recombination determination of adult lifespan response to ionizing radiation DNA translocase activity hydrolase activity macromolecular complex annealing helicase activity response to drug double-strand break repair via synthesis-dependent strand annealing chromosome organization uc008ugd.1 uc008ugd.2 uc008ugd.3 uc008ugd.4 
ENSMUST00000102707.10 Cyp4b1 ENSMUST00000102707.10 cytochrome P450, family 4, subfamily b, polypeptide 1 (from RefSeq NM_007823.3) CP4B1_MOUSE ENSMUST00000102707.1 ENSMUST00000102707.2 ENSMUST00000102707.3 ENSMUST00000102707.4 ENSMUST00000102707.5 ENSMUST00000102707.6 ENSMUST00000102707.7 ENSMUST00000102707.8 ENSMUST00000102707.9 NM_007823 Q64462 uc008ufc.1 uc008ufc.2 uc008ufc.3 Responsible for mutagenic activation of 3-methoxy-4- aminoazobenzene (3-MeO-AAB); a potent procarcinogen. Also active on 2- aminofluorene and 2-aminoanthracene. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Present abundantly in renal microsomes of male mice but not in those of female mice. Also present in pulmonary microsomes of male and female mice. Not found in liver. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane cellular aromatic compound metabolic process drug binding toxic substance binding membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen fluorene oxygenase activity biphenyl metabolic process fluorene metabolic process heme binding organelle membrane exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc008ufc.1 uc008ufc.2 uc008ufc.3 
ENSMUST00000102710.10 Abcb11 ENSMUST00000102710.10 ATP-binding cassette, sub-family B member 11, transcript variant 1 (from RefSeq NM_021022.3) A2AUN4 ABCBB_MOUSE Abcb11 Bsep ENSMUST00000102710.1 ENSMUST00000102710.2 ENSMUST00000102710.3 ENSMUST00000102710.4 ENSMUST00000102710.5 ENSMUST00000102710.6 ENSMUST00000102710.7 ENSMUST00000102710.8 ENSMUST00000102710.9 NM_021022 Q9QY30 Q9QZE8 Spgp uc008jya.1 uc008jya.2 uc008jya.3 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AK144553.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:14570929, PubMed:11172067, PubMed:23764895, PubMed:22619174, PubMed:19228692). Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts (By similarity). Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (By similarity). Reaction=ATP + cholate(in) + H2O = ADP + cholate(out) + H(+) + phosphate; Xref=Rhea:RHEA:50048, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29747, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50049; Evidence=; Reaction=ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out); Xref=Rhea:RHEA:50052, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36257, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50053; Evidence=; Reaction=ATP + glycocholate(in) + H2O = ADP + glycocholate(out) + H(+) + phosphate; Xref=Rhea:RHEA:50056, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29746, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50057; Evidence=; Reaction=ATP + glycochenodeoxycholate(in) + H2O = ADP + glycochenodeoxycholate(out) + H(+) + phosphate; Xref=Rhea:RHEA:50060, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36252, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50061; Evidence=; Reaction=ATP + H2O + taurochenodeoxycholate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate(out); Xref=Rhea:RHEA:50064, ChEBI:CHEBI:9407, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50065; Evidence=; Reaction=ATP + glycoursodeoxycholate(in) + H2O = ADP + glycoursodeoxycholate(out) + H(+) + phosphate; Xref=Rhea:RHEA:50068, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:132030, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50069; Evidence=; Reaction=ATP + H2O + tauroursodeoxycholate(in) = ADP + H(+) + phosphate + tauroursodeoxycholate(out); Xref=Rhea:RHEA:50072, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:132028, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50073; Evidence=; Reaction=ATP + H2O + taurodeoxycholate(in) = ADP + H(+) + phosphate + taurodeoxycholate(out); Xref=Rhea:RHEA:50080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36261, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Reaction=ATP + H2O + taurolithocholate 3-sulfate(in) = ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out); Xref=Rhea:RHEA:50084, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58301, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50085; Evidence=; Reaction=ATP + H2O + pravastatin(in) = ADP + H(+) + phosphate + pravastatin(out); Xref=Rhea:RHEA:63908, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:63660, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63909; Evidence=; The uptake of taurocholate is inhibited by taurolithocholate sulfate with an IC(50) of 9 uM. Pravastatin competitively inhibits the transport of taurocholic acid. Cyclosporin A, glibenclamide, rifampicin and troglitazonestrongly competitively inhibit the transport activity of taurocholate (By similarity). The canalicular transport activity of taurocholate is strongly dependent on canalicular membrane cholesterol content (By similarity) (PubMed:19228692). The uptake of taurocholate is increased by short- and medium-chain fatty acids. Cholesterol increases transport capacity of taurocholate without affecting the affinity for the substrate (By similarity). Interacts with HAX1 (By similarity). Interacts with the adapter protein complex 2 (AP-2) throught AP2A2 or AP2A1; this interaction regulates cell membrane expression of ABCB11 through its internalization in a clathrin-dependent manner and its subsequent degradation (By similarity). Apical cell membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Endosome Cell membrane ; Multi-pass membrane protein Note=Internalized at the canalicular membrane through interaction with the adapter protein complex 2 (AP-2). At steady state, localizes in the canalicular membrane but is also present in recycling endosomes. ABCB11 constantly and rapidly exchanges between the two sites through tubulo-vesicles carriers that move along microtubules. Microtubule-dependent trafficking of ABCB11 is enhanced by taurocholate and cAMP and regulated by STK11 through a PKA-mediated pathway. Trafficking of newly synthesized ABCB11 through endosomal compartment to the bile canalicular membrane is accelerated by cAMP but not by taurocholate (By similarity). Cell membrane expression is up- regulated by short- and medium-chain fatty acids (By similarity). Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ. Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. N-glycosylated. Ubiquitinated; short-chain ubiquitination regulates cell-Surface expression of ABCB11. Transgenic mice with up-regulated liver canalicular membrane expression of Abcb11 appear healthy and normal and demonstrate any difference in longevity. Transgenic mice exhibit a normal reproductive rate and gender distribution and are born in a normal Mendelian distribution. Transgenic mice have food consumption identical to their background strain controls. Transgenic mice manifest increases of both bile flow and biliary lipid secretion and are resistant to the development of hepatic steatosis (PubMed:14570929). Homozygous Abcb11 knockout mice on a mixed genetic background are viable and fertile, but displayed growth retardation. Their body weight is about 20% lower than their wild-type littermates at weaning (21 days after birth). They tend to have a lower body weight throughout their life, but display only mild non progressive cholestasis (PubMed:11172067). Homozygous Abcb11 knockout mice on a pure C57BL/6J background exhibit a progressive intrahepatic cholestasis due to an hepatic bile acid retention and an alteration of lipid metabolism (PubMed:22619174). Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Golgi membrane nucleotide binding ATP binding Golgi apparatus plasma membrane canalicular bile acid transmembrane transporter activity carbohydrate transmembrane transporter activity bile acid and bile salt transport canalicular bile acid transport membrane integral component of membrane apical plasma membrane ATPase activity carbohydrate transmembrane transport response to drug ATPase activity, coupled to transmembrane movement of substances apical part of cell intercellular canaliculus drug export transmembrane transport uc008jya.1 uc008jya.2 uc008jya.3 
ENSMUST00000102713.11 4933409G03Rik ENSMUST00000102713.11 RIKEN cDNA 4933409G03 gene (from RefSeq NM_177651.3) 4933409G03Rik ENSMUST00000102713.1 ENSMUST00000102713.10 ENSMUST00000102713.2 ENSMUST00000102713.3 ENSMUST00000102713.4 ENSMUST00000102713.5 ENSMUST00000102713.6 ENSMUST00000102713.7 ENSMUST00000102713.8 ENSMUST00000102713.9 NM_177651 Q8C5U0 Q8C5U0_MOUSE uc008jxq.1 uc008jxq.2 molecular_function cellular_component biological_process uc008jxq.1 uc008jxq.2 
ENSMUST00000102715.4 Stk39 ENSMUST00000102715.4 serine/threonine kinase 39, transcript variant 7 (from RefSeq NR_178213.1) ENSMUST00000102715.1 ENSMUST00000102715.2 ENSMUST00000102715.3 NR_178213 Q80W13 Q9Z1W9 STK39_MOUSE Spak uc008jxo.1 uc008jxo.2 uc008jxo.3 Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16382158, PubMed:17488636, PubMed:19633012, PubMed:21486947). Specifically recognizes and binds proteins with a RFXV motif (PubMed:14563843). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:14563843, PubMed:16382158, PubMed:17488636, PubMed:19633012, PubMed:21486947). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (By similarity). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (By similarity). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:17488636, PubMed:19633012, PubMed:21486947). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (PubMed:21317537, PubMed:23542070). Phosphorylates RELT (PubMed:16530727). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Activated following phosphorylation at Thr-243 by WNK kinases (WNK1, WNK2, WNK3 or WNK4). The phosphorylated form forms a complex with WNK2 (PubMed:21733846). Interacts with RELT (PubMed:16530727). Interacts with SORL1 (via cytosolic C-terminus) (By similarity). Q9Z1W9; P47811: Mapk14; NbExp=2; IntAct=EBI-444764, EBI-298727; Q9Z1W9; P55012: Slc12a2; NbExp=3; IntAct=EBI-444764, EBI-621078; Q9Z1W9; Q924N4-1: Slc12a6; NbExp=4; IntAct=EBI-444764, EBI-620992; Cytoplasm Nucleus Note=Nucleus when caspase-cleaved. Expressed in the kidney, including in epithelial cells of the thick ascending limb of Henle's loop and in the distal convoluted tubule (at protein level). PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins. Phosphorylation at Thr-243 by WNK kinases (WNK1, WNK2, WNK3 or WNK4) is required for activation (PubMed:16382158, PubMed:21486947). Autophosphorylation at Thr-243 positively regulates its activity (PubMed:16530727). Phosphorylated at Ser-321 by PRKCQ (PubMed:21733846). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. nucleotide binding activation of MAPK activity protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol cytoskeleton protein phosphorylation regulation of blood pressure positive regulation of T cell chemotaxis membrane kinase activity phosphorylation basolateral plasma membrane apical plasma membrane transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation extrinsic component of membrane protein kinase binding signal transduction by protein phosphorylation signal transduction by trans-phosphorylation activation of protein kinase activity positive regulation of ion transmembrane transporter activity intracellular signal transduction maintenance of lens transparency chemokine (C-X-C motif) ligand 12 signaling pathway intracellular membrane-bounded organelle positive regulation of potassium ion transport protein autophosphorylation regulation of inflammatory response ion homeostasis cellular hypotonic response negative regulation of pancreatic juice secretion negative regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transport negative regulation of creatine transmembrane transporter activity cellular response to chemokine negative regulation of sodium ion transmembrane transporter activity uc008jxo.1 uc008jxo.2 uc008jxo.3 
ENSMUST00000102718.10 Ttc21b ENSMUST00000102718.10 tetratricopeptide repeat domain 21B, transcript variant 1 (from RefSeq NM_001047604.3) ENSMUST00000102718.1 ENSMUST00000102718.2 ENSMUST00000102718.3 ENSMUST00000102718.4 ENSMUST00000102718.5 ENSMUST00000102718.6 ENSMUST00000102718.7 ENSMUST00000102718.8 ENSMUST00000102718.9 Ift139 Kiaa1992 NM_001047604 Q0HA38 Q3V1U7 Q69Z46 TT21B_MOUSE Thm1 uc008jwv.1 uc008jwv.2 uc008jwv.3 Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Essential for retrograde trafficking of IFT- 1, IFT-B and GPCRs (By similarity). Negatively modulates the SHH signal transduction (PubMed:18327258). Component of the IFT complex A (IFT-A) complex. IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B. Interacts directy with WDR35 and TTC21B (By similarity). Interacts with TTC25 (PubMed:25860617). Cytoplasm, cytoskeleton, cilium axoneme Note=In polarized epithelial inner medullary collecting ducts cells and in the nodes of mice at 8.0 dpc, colocalizes with alpha-tubulin in cilia. Expressed in a punctate manner throughout the axoneme from the cilia base to the tip. At 10.5 dpc, widely expressed with more intense expression in the maxillary prominence, branchial arches, limb buds, somites and spinal cord. Belongs to the TTC21 family. Sequence=BAD32598.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32598.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Aberrant splice sites.; Evidence=; molecular_function cytoplasm cytoskeleton cilium regulation of transcription from RNA polymerase II promoter smoothened signaling pathway regulation of smoothened signaling pathway ventricular system development forebrain dorsal/ventral pattern formation intraciliary transport particle A intraciliary retrograde transport cell projection protein localization to cilium nuclear chromatin uc008jwv.1 uc008jwv.2 uc008jwv.3 
ENSMUST00000102721.8 Slc5a9 ENSMUST00000102721.8 solute carrier family 5 (sodium/glucose cotransporter), member 9 (from RefSeq NM_145551.4) ENSMUST00000102721.1 ENSMUST00000102721.2 ENSMUST00000102721.3 ENSMUST00000102721.4 ENSMUST00000102721.5 ENSMUST00000102721.6 ENSMUST00000102721.7 NM_145551 Q8BGU9 Q8BZW1 Q8VDT1 SC5A9_MOUSE Sglt4 uc008udk.1 uc008udk.2 uc008udk.3 uc008udk.4 Electrogenic Na(+)-coupled sugar symporter that may play a primary role in D-mannose and possibly D-fructose and D-glucose transport at the plasma membrane. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2. Reaction=D-mannose(out) + n Na(+)(out) = D-mannose(in) + n Na(+)(in); Xref=Rhea:RHEA:75475, ChEBI:CHEBI:4208, ChEBI:CHEBI:29101; Evidence=; Cell membrane ; Multi-pass membrane protein Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. glucose:sodium symporter activity plasma membrane ion transport sodium ion transport membrane integral component of membrane transmembrane transporter activity transmembrane transport glucose transmembrane transport uc008udk.1 uc008udk.2 uc008udk.3 uc008udk.4 
ENSMUST00000102724.5 Faf1 ENSMUST00000102724.5 Fas-associated factor 1, transcript variant 5 (from RefSeq NR_184816.1) ENSMUST00000102724.1 ENSMUST00000102724.2 ENSMUST00000102724.3 ENSMUST00000102724.4 FAF1_MOUSE NR_184816 P54731 Q6P1F8 uc008uct.1 uc008uct.2 uc008uct.3 Ubiquitin-binding protein (By similarity). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (By similarity). Potentiates but cannot initiate FAS-induced apoptosis (PubMed:8524870). Interacts with CDT1 and ATPase VCP/p97. Interacts (via UBA domain) with FAS (via death domain). Interacts (via UBA domain) with NLRP12 (via DAPIN/PYRIN domain). Nucleus protein binding nucleus nuclear envelope cytoplasm cytosol apoptotic process cytoplasmic sequestering of NF-kappaB cell death positive regulation of cell death protein kinase binding protein domain specific binding regulation of cell adhesion heat shock protein binding positive regulation of protein complex assembly ubiquitin protein ligase binding VCP-NPL4-UFD1 AAA ATPase complex regulation of protein catabolic process ubiquitin binding positive regulation of DNA replication perinuclear region of cytoplasm NF-kappaB binding positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of cellular protein catabolic process uc008uct.1 uc008uct.2 uc008uct.3 
ENSMUST00000102726.8 Cobll1 ENSMUST00000102726.8 Cobl-like 1, transcript variant 1 (from RefSeq NM_177025.6) B1AZ15 B1AZ15_MOUSE Cobll1 ENSMUST00000102726.1 ENSMUST00000102726.2 ENSMUST00000102726.3 ENSMUST00000102726.4 ENSMUST00000102726.5 ENSMUST00000102726.6 ENSMUST00000102726.7 NM_177025 uc008jwa.1 uc008jwa.2 uc008jwa.3 uc008jwa.4 actin monomer binding uc008jwa.1 uc008jwa.2 uc008jwa.3 uc008jwa.4 
ENSMUST00000102727.3 Anxa6 ENSMUST00000102727.3 annexin A6, transcript variant 2 (from RefSeq NM_001110211.2) Anxa6 ENSMUST00000102727.1 ENSMUST00000102727.2 F8WIT2 F8WIT2_MOUSE NM_001110211 uc007iys.1 uc007iys.2 uc007iys.3 uc007iys.4 May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Melanosome A pair of annexin repeats may form one binding site for calcium and phospholipid. Belongs to the annexin family. calcium ion binding calcium-dependent phospholipid binding uc007iys.1 uc007iys.2 uc007iys.3 uc007iys.4 
ENSMUST00000102729.10 Eps15 ENSMUST00000102729.10 epidermal growth factor receptor pathway substrate 15, transcript variant 1 (from RefSeq NM_007943.3) ENSMUST00000102729.1 ENSMUST00000102729.2 ENSMUST00000102729.3 ENSMUST00000102729.4 ENSMUST00000102729.5 ENSMUST00000102729.6 ENSMUST00000102729.7 ENSMUST00000102729.8 ENSMUST00000102729.9 Eps15 NM_007943 Q80ZL3 Q80ZL3_MOUSE uc008ucf.1 uc008ucf.2 uc008ucf.3 uc008ucf.4 uc008ucf.5 positive regulation of receptor recycling calcium ion binding early endosome cytosol plasma membrane Golgi to endosome transport basal plasma membrane aggresome apical plasma membrane receptor-mediated endocytosis of virus by host cell polyubiquitin binding endocytic recycling regulation of cell proliferation intracellular membrane-bounded organelle synapse viral entry into host cell clathrin coat assembly postsynapse postsynaptic neurotransmitter receptor internalization glutamatergic synapse uc008ucf.1 uc008ucf.2 uc008ucf.3 uc008ucf.4 uc008ucf.5 
ENSMUST00000102731.8 Tnip1 ENSMUST00000102731.8 TNFAIP3 interacting protein 1, transcript variant 2 (from RefSeq NM_001199275.2) E9QM75 E9QM75_MOUSE ENSMUST00000102731.1 ENSMUST00000102731.2 ENSMUST00000102731.3 ENSMUST00000102731.4 ENSMUST00000102731.5 ENSMUST00000102731.6 ENSMUST00000102731.7 NM_001199275 Tnip1 uc007iyl.1 uc007iyl.2 uc007iyl.3 uc007iyl.4 uc007iyl.5 MyD88-dependent toll-like receptor signaling pathway nucleoplasm cytosol leukocyte cell-cell adhesion glycoprotein biosynthetic process identical protein binding negative regulation of I-kappaB kinase/NF-kappaB signaling regulation of inflammatory response mitogen-activated protein kinase binding negative regulation of ERK1 and ERK2 cascade modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade positive regulation of protein deubiquitination uc007iyl.1 uc007iyl.2 uc007iyl.3 uc007iyl.4 uc007iyl.5 
ENSMUST00000102732.10 Fap ENSMUST00000102732.10 fibroblast activation protein (from RefSeq NM_007986.3) ENSMUST00000102732.1 ENSMUST00000102732.2 ENSMUST00000102732.3 ENSMUST00000102732.4 ENSMUST00000102732.5 ENSMUST00000102732.6 ENSMUST00000102732.7 ENSMUST00000102732.8 ENSMUST00000102732.9 Fap NM_007986 P97321 SEPR_MOUSE uc008jvk.1 uc008jvk.2 uc008jvk.3 uc008jvk.4 This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available. [provided by RefSeq, Apr 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y10007.1, BC019190.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2. Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein. Also has dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner. Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.; EC=3.4.21.26; Evidence=; Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.; EC=3.4.14.5; Evidence= Gelatinase activity is inhibited by serine- protease inhibitors, such as phenylmethylsulfonyl fluoride (PMSF), 4- (2-aminoethyl)-benzenesulfonyl fluoride hydrochloride (AEBSF), 4- amidino phenylsulfonyl fluoride (APSF) and diisopropyl fluorophosphate (DFP), N-ethylmaleimide (NEM) and phenylmethylsulfonyl fluoride (PMSF). Dipeptidyl peptidase activity is inhibited by 2,2'-azino-bis(3- ethylbenzthiazoline-6-sulfonic acid), diisopropylfluorophosphate (DFP). Prolyl endopeptidase activity is inhibited by the boronic acid peptide Ac-Gly-BoroPro, Ac-Gly-Pro-chloromethyl ketone and Thr-Ser-Gly- chloromethyl ketone. Homodimer; homodimerization is required for activity of both plasma membrane and soluble forms. The monomer is inactive. Heterodimer with DPP4. Interacts with PLAUR; the interaction occurs at the cell surface of invadopodia membranes. Interacts with ITGB1. Interacts with ITGA3. Associates with integrin alpha-3/beta-1; the association occurs in a collagen-dependent manner at the cell surface of invadopodia membranes. [Prolyl endopeptidase FAP]: Cell surface Cell membrane ; Single-pass type II membrane protein Cell projection, lamellipodium membrane ; Single-pass type II membrane protein Cell projection, invadopodium membrane ; Single-pass type II membrane protein Cell projection, ruffle membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Note=Localized on cell surface with lamellipodia and invadopodia membranes and on shed vesicles. Colocalized with DPP4 at invadopodia and lamellipodia membranes of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Anchored and enriched preferentially by integrin alpha- 3/beta-1 at invadopodia, plasma membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. Colocalized with PLAUR preferentially at the cell surface of invadopodia membranes in a cytoskeleton-, integrin- and vitronectin- dependent manner. Concentrated at invadopodia membranes, specialized protrusions of the ventral plasma membrane in a fibrobectin-dependent manner. Colocalizes with extracellular components (ECM), such as collagen fibers and fibronectin. [Antiplasmin-cleaving enzyme FAP, soluble form]: Secreted Note=Found in blood plasma and serum. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P97321-1; Sequence=Displayed; Name=2; IsoId=P97321-2; Sequence=VSP_005368; Name=3; IsoId=P97321-3; Sequence=VSP_005369; Expressed strongly in uterus, pancreas, submaxillary gland and skin, less in lymph node, ovary, skeletal muscle, adrenal and bone marrow. Expressed in reactive stromal fibroblast in epithelial cancers. Expressed in melanocytes but not melanomas (at protein level). Detected in fibroblasts, in placenta, uterus, embryos from day 7-19 and in newborn mice (P1). Expressed in developing myotubes at 11.5 dpc. Expressed in the dermomyotome component of the somites at 12.5 dpc. Expressed in fibroblasts at 13 dpc. Expressed in the perichondrial mesenchymal cells from the cartilage primordium of the ribs and in the scattered developing intercostal muscle fibs at 16.5 dpc (at protein level). Expressed in the primitive mesenchymal condensation adjacent to the eye and in primitive mesenchymal cells surrounding the cartilaginous primordia of the bones at 13.5 dpc. N-glycosylated. The N-terminus may be blocked. No visible phenotype. Mice are viable and fertile and display no overt developmental defects and no general change in cancer susceptibiliy. Belongs to the peptidase S9B family. angiogenesis protease binding endopeptidase activity serine-type endopeptidase activity integrin binding extracellular region extracellular space plasma membrane proteolysis apoptotic process cell adhesion peptidase activity serine-type peptidase activity dipeptidyl-peptidase activity cell surface regulation of collagen catabolic process negative regulation of extracellular matrix disassembly membrane integral component of membrane hydrolase activity lamellipodium cell junction lamellipodium membrane ruffle membrane protein homodimerization activity cell projection endothelial cell migration apical part of cell basal part of cell proteolysis involved in cellular protein catabolic process negative regulation of cell proliferation involved in contact inhibition positive regulation of cell cycle arrest invadopodium membrane mitotic cell cycle arrest melanocyte proliferation positive regulation of execution phase of apoptosis melanocyte apoptotic process negative regulation of extracellular matrix organization uc008jvk.1 uc008jvk.2 uc008jvk.3 uc008jvk.4 
ENSMUST00000102733.10 Gcg ENSMUST00000102733.10 glucagon (from RefSeq NM_008100.4) ENSMUST00000102733.1 ENSMUST00000102733.2 ENSMUST00000102733.3 ENSMUST00000102733.4 ENSMUST00000102733.5 ENSMUST00000102733.6 ENSMUST00000102733.7 ENSMUST00000102733.8 ENSMUST00000102733.9 GLUC_MOUSE NM_008100 P55095 Q3UFE9 uc008jvj.1 uc008jvj.2 uc008jvj.3 This gene encodes glucagon, a pancreatic hormone that counteracts the action of insulin in the bloodstream. The encoded protein is processed to generate glucagon and two other glucagon-like peptides, GLP1 and GLP2. Glucagon stimulates gluconeogenesis, glycogenolysis and lipolysis. GLP1 induces secretion of insulin, suppresses glucagon secretion and inhibits feeding. GLP2 induces intestinal absorption of glucose by stimulating the growth of intestinal cells and preventing apoptosis. [provided by RefSeq, Apr 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF276754.1, CF586022.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849389 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. [Glucagon-like peptide 1]: Potent stimulator of glucose- dependent insulin release. Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth- promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable). [Glucagon-like peptide 2]: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. [Oxyntomodulin]: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. [Glicentin]: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. Secreted [Glucagon-like peptide 1]: Secreted [Glucagon]: Secreted in the A cells of the islets of Langerhans. [Glucagon-like peptide 1]: Secreted in the A cells of the islets of Langerhans (PubMed:22037645). Secreted from enteroendocrine L cells throughout the gastrointestinal tract (PubMed:22037645). Also secreted in selected neurons in the brain. [Glucagon-like peptide 2]: Secreted from enteroendocrine cells throughout the gastrointestinal tract. Also secreted in selected neurons in the brain. [Glicentin]: Secreted from enteroendocrine cells throughout the gastrointestinal tract. [Oxyntomodulin]: Secreted from enteroendocrine cells throughout the gastrointestinal tract. [Glucagon]: Release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. [Glucagon-like peptide 1]: Production by pancreatic and inestinal L cells is increased by exercise in an IL6-dependent manner (PubMed:22037645). High-fat diet increases pancreatic content (PubMed:22037645). [Glucagon-like peptide 2]: Induced in response to nutrient ingestion. Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post- translational processing in the intestinal L cells resulting in GLP- 1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas (By similarity). Belongs to the glucagon family. hormone activity extracellular region extracellular space cytoplasm adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway protein kinase A signaling positive regulation of peptidyl-threonine phosphorylation glucagon receptor binding positive regulation of protein binding negative regulation of appetite positive regulation of peptidyl-serine phosphorylation secretory granule lumen positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter identical protein binding negative regulation of apoptotic process positive regulation of protein kinase activity regulation of insulin secretion positive regulation of histone H3-K4 methylation positive regulation of ERK1 and ERK2 cascade positive regulation of calcium ion import negative regulation of execution phase of apoptosis negative regulation of intrinsic apoptotic signaling pathway uc008jvj.1 uc008jvj.2 uc008jvj.3 
ENSMUST00000102738.4 Kti12 ENSMUST00000102738.4 KTI12 homolog, chromatin associated (from RefSeq NM_029571.2) ENSMUST00000102738.1 ENSMUST00000102738.2 ENSMUST00000102738.3 KTI12_MOUSE NM_029571 Q3UG06 Q9D1R2 uc008ubt.1 uc008ubt.2 uc008ubt.3 Belongs to the KTI12 family. Sequence=BAE28403.1; Type=Erroneous initiation; Evidence=; nucleotide binding tRNA wobble uridine modification molecular_function ATP binding regulation of transcription from RNA polymerase II promoter Elongator holoenzyme complex uc008ubt.1 uc008ubt.2 uc008ubt.3 
ENSMUST00000102742.11 Btf3l4 ENSMUST00000102742.11 basic transcription factor 3-like 4, transcript variant 1 (from RefSeq NM_027453.4) BT3L4_MOUSE ENSMUST00000102742.1 ENSMUST00000102742.10 ENSMUST00000102742.2 ENSMUST00000102742.3 ENSMUST00000102742.4 ENSMUST00000102742.5 ENSMUST00000102742.6 ENSMUST00000102742.7 ENSMUST00000102742.8 ENSMUST00000102742.9 NM_027453 Q9CQH7 uc008ubp.1 uc008ubp.2 uc008ubp.3 Belongs to the NAC-beta family. cellular_component biological_process uc008ubp.1 uc008ubp.2 uc008ubp.3 
ENSMUST00000102743.10 Rapgef6 ENSMUST00000102743.10 Rap guanine nucleotide exchange factor (GEF) 6, transcript variant 2 (from RefSeq NM_175258.4) ENSMUST00000102743.1 ENSMUST00000102743.2 ENSMUST00000102743.3 ENSMUST00000102743.4 ENSMUST00000102743.5 ENSMUST00000102743.6 ENSMUST00000102743.7 ENSMUST00000102743.8 ENSMUST00000102743.9 NM_175258 Q5NCJ0 Q5NCJ0_MOUSE Rapgef6 uc007ixz.1 uc007ixz.2 uc007ixz.3 uc007ixz.4 Cell junction Cell membrane Cytoplasm, perinuclear region Endosome Late endosome Membrane Belongs to the RAPGEF2 family. guanyl-nucleotide exchange factor activity centrosome cytosol plasma membrane signal transduction small GTPase mediated signal transduction apical plasma membrane Ras GTPase binding microvillus assembly endocytic vesicle GTP-dependent protein binding positive regulation of GTPase activity phosphatidic acid binding protein localization to plasma membrane uc007ixz.1 uc007ixz.2 uc007ixz.3 uc007ixz.4 
ENSMUST00000102744.4 Orc1 ENSMUST00000102744.4 origin recognition complex, subunit 1 (from RefSeq NM_011015.2) A2A8R3 ENSMUST00000102744.1 ENSMUST00000102744.2 ENSMUST00000102744.3 NM_011015 ORC1_MOUSE Orc1l Q9Z1N2 uc008ubh.1 uc008ubh.2 uc008ubh.3 uc008ubh.4 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Interacts with CDC6 and KAT7/HBO1 (By similarity). Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated (By similarity). Nucleus The BAH domain mediates binding to dimethylated histone H4 'Lys-20' (H4K20me2), which is enriched at replication origins. Phosphorylated during mitosis. Belongs to the ORC1 family. nucleotide binding mitotic cell cycle nuclear chromosome, telomeric region origin recognition complex DNA binding chromatin binding DNA replication origin binding ATP binding nucleus nuclear origin of replication recognition complex nucleolus cytosol plasma membrane DNA replication DNA replication initiation mitotic DNA replication checkpoint metal ion binding positive regulation of smooth muscle cell proliferation positive regulation of G0 to G1 transition uc008ubh.1 uc008ubh.2 uc008ubh.3 uc008ubh.4 
ENSMUST00000102745.10 Tnfaip2 ENSMUST00000102745.10 tumor necrosis factor, alpha-induced protein 2 (from RefSeq NM_009396.2) ENSMUST00000102745.1 ENSMUST00000102745.2 ENSMUST00000102745.3 ENSMUST00000102745.4 ENSMUST00000102745.5 ENSMUST00000102745.6 ENSMUST00000102745.7 ENSMUST00000102745.8 ENSMUST00000102745.9 NM_009396 Q3T9B0 Q3TCH9 Q61333 Q922G1 TNAP2_MOUSE uc007pcz.1 uc007pcz.2 uc007pcz.3 uc007pcz.4 May play a role as a mediator of inflammation and angiogenesis. In 10-day embryos B94 is expressed prominently in the myocardium and in the aortic arch. By the 15th day of gestation, expression is restricted largely to the liver, the bone forming regions of the jaw, the aortic endothelium, and the nasopharynx: a pattern that is maintained until just prior to birth. Postnatally, expression shifts to the red pulp of the spleen and the thymic medulla. Belongs to the SEC6 family. Sequence=AAA72044.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; exocyst SNARE binding angiogenesis exocytosis multicellular organism development cell differentiation exocyst localization uc007pcz.1 uc007pcz.2 uc007pcz.3 uc007pcz.4 
ENSMUST00000102746.11 Uba2 ENSMUST00000102746.11 ubiquitin-like modifier activating enzyme 2, transcript variant 8 (from RefSeq NR_184754.1) ENSMUST00000102746.1 ENSMUST00000102746.10 ENSMUST00000102746.2 ENSMUST00000102746.3 ENSMUST00000102746.4 ENSMUST00000102746.5 ENSMUST00000102746.6 ENSMUST00000102746.7 ENSMUST00000102746.8 ENSMUST00000102746.9 NR_184754 Q3TQN3 Q3U819 Q3U9J5 Q8BVX9 Q9Z1F9 SAE2_MOUSE Sae2 Uble1b uc009giu.1 uc009giu.2 uc009giu.3 The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity). Protein modification; protein sumoylation. Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I (By similarity). Cytoplasm Nucleus Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention. Broadly expressed, with highest levels in testis. Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys- 236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking (By similarity). Belongs to the ubiquitin-activating E1 family. nucleotide binding magnesium ion binding protein binding ATP binding nucleus nucleoplasm cytoplasm transcription factor binding small protein activating enzyme activity transferase activity protein sumoylation SUMO activating enzyme activity SUMO activating enzyme complex SUMO binding protein modification by small protein conjugation small protein activating enzyme binding ubiquitin-like protein conjugating enzyme binding metal ion binding protein heterodimerization activity uc009giu.1 uc009giu.2 uc009giu.3 
ENSMUST00000102748.11 Marchf7 ENSMUST00000102748.11 membrane associated ring-CH-type finger 7, transcript variant 13 (from RefSeq NR_184759.1) Axot ENSMUST00000102748.1 ENSMUST00000102748.10 ENSMUST00000102748.2 ENSMUST00000102748.3 ENSMUST00000102748.4 ENSMUST00000102748.5 ENSMUST00000102748.6 ENSMUST00000102748.7 ENSMUST00000102748.8 ENSMUST00000102748.9 MARH7_MOUSE March7 NR_184759 Q9WV66 uc008jtx.1 uc008jtx.2 uc008jtx.3 E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis. Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7. Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Cytoplasm Expressed in brain, thymus, muscle and kidney. Highly expressed in most tissues up to 15.5 dpc. Thereafter, expressed at highest levels in the nervous system. The RING-CH-type zinc finger domain is required for E3 ligase activity. Mice have defects in formation of corpus callosum and show degeneration of substantia gelatinosa lamina II axons in adulthood. They have normal lymphoid development but show hyperproliferation of T-cells in response to mitogens. regulation of tolerance induction nucleus cytosol plasma membrane zinc ion binding positive regulation of cell proliferation protein ubiquitination transferase activity enzyme binding ubiquitin conjugating enzyme binding negative regulation of T cell proliferation ubiquitin binding negative regulation of DNA damage response, signal transduction by p53 class mediator metal ion binding protein stabilization protein autoubiquitination MDM2/MDM4 family protein binding negative regulation of proteasomal protein catabolic process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of protein polyubiquitination negative regulation of protein autoubiquitination uc008jtx.1 uc008jtx.2 uc008jtx.3 
ENSMUST00000102749.11 Arnt ENSMUST00000102749.11 aryl hydrocarbon receptor nuclear translocator, transcript variant 7 (from RefSeq NM_001409522.1) ARNT_MOUSE ENSMUST00000102749.1 ENSMUST00000102749.10 ENSMUST00000102749.2 ENSMUST00000102749.3 ENSMUST00000102749.4 ENSMUST00000102749.5 ENSMUST00000102749.6 ENSMUST00000102749.7 ENSMUST00000102749.8 ENSMUST00000102749.9 NM_001409522 P53762 Q60661 Q921F3 uc008qjt.1 uc008qjt.2 uc008qjt.3 uc008qjt.4 uc008qjt.5 Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (PubMed:26245371, PubMed:27782878). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (PubMed:26245371, PubMed:27782878). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820, PubMed:26245371, PubMed:27782878). Monomer (PubMed:28602820). Homodimer only upon binding to a DNA (PubMed:26245371, PubMed:28602820). Efficient DNA binding requires dimerization with another bHLH protein (By similarity). Interacts with TACC3 (PubMed:11025203). Interacts with HIF1A, EPAS1, NPAS1 and NPAS3; forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371, PubMed:27782878). Forms a heterodimer with AHRR, as well as with other bHLH proteins (PubMed:9887096). Interacts with NOCA7 (By similarity). Interacts with AHR; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820, PubMed:24001774, PubMed:27782878). Interacts with SIM1 and NPAS4 (PubMed:27782878). P53762; P97481: Epas1; NbExp=5; IntAct=EBI-78852, EBI-15704570; P53762; Q61221-1: Hif1a; NbExp=5; IntAct=EBI-78852, EBI-8549331; P53762; Q61045: Sim1; NbExp=4; IntAct=EBI-78852, EBI-78890; Nucleus Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P53762-1; Sequence=Displayed; Name=Short; IsoId=P53762-2; Sequence=VSP_002093; Ubiquitous. RNA polymerase II transcription factor activity, sequence-specific DNA binding response to hypoxia embryonic placenta development DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm regulation of transcription, DNA-templated transcription factor binding response to toxic substance positive regulation of vascular endothelial growth factor production nuclear body aryl hydrocarbon receptor binding cell differentiation intracellular receptor signaling pathway positive regulation of protein sumoylation enhancer binding protein homodimerization activity sequence-specific DNA binding regulation of transcription from RNA polymerase II promoter in response to oxidative stress positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of hormone biosynthetic process protein heterodimerization activity protein dimerization activity RNA polymerase II transcription factor complex sequence-specific double-stranded DNA binding uc008qjt.1 uc008qjt.2 uc008qjt.3 uc008qjt.4 uc008qjt.5 
ENSMUST00000102754.11 Pkp4 ENSMUST00000102754.11 plakophilin 4, transcript variant 1 (from RefSeq NM_026361.2) A2AS46 Armrp ENSMUST00000102754.1 ENSMUST00000102754.10 ENSMUST00000102754.2 ENSMUST00000102754.3 ENSMUST00000102754.4 ENSMUST00000102754.5 ENSMUST00000102754.6 ENSMUST00000102754.7 ENSMUST00000102754.8 ENSMUST00000102754.9 NM_026361 PKP4_MOUSE Q640N0 Q68FH0 Q68G56 Q8BK47 Q8BVH1 Q9CRE3 uc008jtc.1 uc008jtc.2 Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity). Interacts (via the C-terminus) with FRMPD2 (via the PDZ 2 domain). Interacts with PDZD2. Interacts with RHOA; the interaction is detected at the midbody. Interacts with ECT2; the interaction is detected at the midbody (By similarity). Interacts with CCDC85B (By similarity). Cell junction, desmosome Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Midbody Cell membrane ; Peripheral membrane protein Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q68FH0-1; Sequence=Displayed; Name=2; IsoId=Q68FH0-2; Sequence=VSP_012377; Name=3; IsoId=Q68FH0-3; Sequence=VSP_012374, VSP_012375, VSP_012376; Belongs to the beta-catenin family. Sequence=BAC37187.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; spindle pole nucleus cytoplasm spindle cytoskeleton plasma membrane cell-cell junction cell-cell adherens junction cell-cell junction assembly cell adhesion cytoplasmic side of plasma membrane postsynaptic density membrane cell junction desmosome midbody positive regulation of cytokinesis positive regulation of GTPase activity cell-cell contact zone cadherin binding perinuclear region of cytoplasm spindle midzone mitotic spindle cell-cell adhesion uc008jtc.1 uc008jtc.2 
ENSMUST00000102755.4 Upp2 ENSMUST00000102755.4 uridine phosphorylase 2, transcript variant 3 (from RefSeq NM_029692.3) ENSMUST00000102755.1 ENSMUST00000102755.2 ENSMUST00000102755.3 NM_029692 Q8CGR7 UPP2_MOUSE Upp2 uc008jsw.1 uc008jsw.2 uc008jsw.3 uc008jsw.4 Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed:14715930). Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (By similarity). Reaction=phosphate + uridine = alpha-D-ribose 1-phosphate + uracil; Xref=Rhea:RHEA:24388, ChEBI:CHEBI:16704, ChEBI:CHEBI:17568, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24389; Evidence=; Reaction=2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + uracil; Xref=Rhea:RHEA:22824, ChEBI:CHEBI:16450, ChEBI:CHEBI:17568, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22825; Evidence=; A conditional disulfide bridge can form within the protein that dislocates a critical phosphate-coordinating arginine Arg- 100 away from the active site, disabling the enzyme. Kinetic parameters: KM=241.7 uM for uridine ; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1. Homodimer. Liver specific. Directly up-regulated in liver by HNF-4-alpha (HNF4A) binding to the promoter. May also be indirectly regulated by signaling via various orphan nuclear receptors. Strongly up-regulated by a liver X receptor (LXR) agonist. Slightly up-regulated by a pregnane X receptor (PXR) agonist. Strongly repressed by a peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Slightly repressed by a farnesoid X receptor (FXR) agonist. Shows a diurnal expression pattern with peak levels 12 hours after light onset and lowest levels 0 hours after light onset. Belongs to the PNP/UDP phosphorylase family. catalytic activity uridine phosphorylase activity cytoplasm nucleoside metabolic process nucleotide catabolic process transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups identical protein binding UMP salvage type III intermediate filament uc008jsw.1 uc008jsw.2 uc008jsw.3 uc008jsw.4 
ENSMUST00000102758.8 Vdac1 ENSMUST00000102758.8 voltage-dependent anion channel 1, transcript variant 2 (from RefSeq NM_011694.7) B1ASZ9 ENSMUST00000102758.1 ENSMUST00000102758.2 ENSMUST00000102758.3 ENSMUST00000102758.4 ENSMUST00000102758.5 ENSMUST00000102758.6 ENSMUST00000102758.7 NM_011694 Q5SVC6 Q60932 VDAC1_MOUSE Vdac5 uc007ivm.1 uc007ivm.2 uc007ivm.3 uc007ivm.4 This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Multiple pseudogenes of this gene are found on chromosomes 1, 2, 3, 6, 8, 9, and X. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC092257.1, SRR1660821.29003.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (By similarity). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:10716730, PubMed:15477379, PubMed:18988731). May mediate ATP export from cells (By similarity). Inhibited by nitric oxide. Homodimer and homotrimer; in response to cyclic AMP or calcium (By similarity). Interacts with hexokinases including HK1. The HK1- VDAC1 complex interacts with ATF2. Interacts with BCL2L1. Interacts with BAK1. Interacts with RTL10/BOP (via BH3 domain) (By similarity). Interacts with amyloid-beta and APP; induces VDAC1 dephosphorylation (PubMed:25168729). Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF. Interacts with SPG7, NIPSNAP2 and SLC25A30 (By similarity). Interacts with TMEM41B (By similarity). Interacts with BCAP31 (By similarity). [Isoform Mt-VDAC1]: Mitochondrion outer membrane ; Multi-pass membrane protein [Isoform Pl-VDAC1]: Cell membrane ; Multi-pass membrane protein Membrane raft ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=Pl-VDAC1; IsoId=Q60932-1; Sequence=Displayed; Name=Mt-VDAC1; IsoId=Q60932-2; Sequence=VSP_005075; High levels of expression detected in heart, kidney, brain, and skeletal muscle. Not expressed in testis. Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity. Phosphorylation at Ser-206 by NEK1 promotes the open conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury. Phosphorylation by the AKT-GSK3B axis stabilizes the protein probably by preventing ubiquitin-mediated proteasomal degradation. Ubiquitinated (PubMed:32047033). Undergoes monoubiquitination and polyubiquitination by PRKN; monoubiquitination at Lys-287 inhibits apoptosis, whereas polyubiquitination leads to its degradation and promotes mitophagy (PubMed:32047033). Deubiquitinated by USP30 (By similarity). Belongs to the eukaryotic mitochondrial porin family. nucleotide binding behavioral fear response anion channel activity protein binding mitochondrion mitochondrial outer membrane mitochondrial inner membrane mitochondrial permeability transition pore complex plasma membrane ion transport anion transport mitochondrial calcium ion transport apoptotic process chemical synaptic transmission neuron-neuron synaptic transmission learning synaptic vesicle voltage-gated anion channel activity porin activity inorganic anion transport membrane integral component of membrane protein kinase binding epithelial cell differentiation macromolecular complex mitochondrial nucleoid identical protein binding myelin sheath ion channel binding macromolecular complex binding membrane raft pore complex transmembrane transport anion transmembrane transport regulation of mitophagy negative regulation of reactive oxygen species metabolic process uc007ivm.1 uc007ivm.2 uc007ivm.3 uc007ivm.4 
ENSMUST00000102759.8 Stam2 ENSMUST00000102759.8 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, transcript variant 1 (from RefSeq NM_019667.3) ENSMUST00000102759.1 ENSMUST00000102759.2 ENSMUST00000102759.3 ENSMUST00000102759.4 ENSMUST00000102759.5 ENSMUST00000102759.6 ENSMUST00000102759.7 NM_019667 Q3TGH8 Q3TGH8_MOUSE RP23-413K16.1-001 Stam2 uc008jre.1 uc008jre.2 uc008jre.3 Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the STAM family. nucleoplasm cytoplasm cytosol intracellular protein transport intracellular membrane-bounded organelle uc008jre.1 uc008jre.2 uc008jre.3 
ENSMUST00000102760.10 Cacnb4 ENSMUST00000102760.10 calcium channel, voltage-dependent, beta 4 subunit, transcript variant 2 (from RefSeq NM_146123.4) CACB4_MOUSE Cacnb4 Cacnlb4 ENSMUST00000102760.1 ENSMUST00000102760.2 ENSMUST00000102760.3 ENSMUST00000102760.4 ENSMUST00000102760.5 ENSMUST00000102760.6 ENSMUST00000102760.7 ENSMUST00000102760.8 ENSMUST00000102760.9 NM_146123 Q3UHK2 Q8BRN6 Q8CAJ9 Q8R0S4 uc008jra.1 uc008jra.2 uc008jra.3 uc008jra.4 The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with FASLG (By similarity). Interacts with CBARP (PubMed:24751537). Q8R0S4; Q91V89: Ppp2r5d; NbExp=2; IntAct=EBI-3647752, EBI-8028449; Q8R0S4; Q8IUD2-2: ERC1; Xeno; NbExp=2; IntAct=EBI-3647752, EBI-6920871; Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q8R0S4-3; Sequence=Displayed; Name=1; IsoId=Q8R0S4-1; Sequence=VSP_022599; Name=2; IsoId=Q8R0S4-2; Sequence=VSP_010737; Belongs to the calcium channel beta subunit family. voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity protein binding nucleolus cytoplasm plasma membrane voltage-gated calcium channel complex ion transport calcium ion transport gamma-aminobutyric acid signaling pathway chemical synaptic transmission neuromuscular junction development adult walking behavior negative regulation of cell proliferation high voltage-gated calcium channel activity gamma-aminobutyric acid secretion nuclear speck neuronal action potential propagation protein kinase binding regulation of ion transmembrane transport synaptic transmission, glutamatergic regulation of membrane potential synapse cAMP metabolic process spleen development thymus development Peyer's patch development muscle fiber development T cell receptor signaling pathway neurological system process detection of light stimulus involved in visual perception calcium ion transmembrane transport presynapse glutamatergic synapse positive regulation of presynaptic cytosolic calcium concentration voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration regulation of voltage-gated calcium channel activity positive regulation of voltage-gated calcium channel activity positive regulation of protein localization to nucleolus cellular response to leukemia inhibitory factor negative regulation of G1/S transition of mitotic cell cycle regulation of synaptic vesicle exocytosis uc008jra.1 uc008jra.2 uc008jra.3 uc008jra.4 
ENSMUST00000102762.10 Acot11 ENSMUST00000102762.10 acyl-CoA thioesterase 11, transcript variant 2 (from RefSeq NM_025590.4) ACO11_MOUSE Bfit ENSMUST00000102762.1 ENSMUST00000102762.2 ENSMUST00000102762.3 ENSMUST00000102762.4 ENSMUST00000102762.5 ENSMUST00000102762.6 ENSMUST00000102762.7 ENSMUST00000102762.8 ENSMUST00000102762.9 NM_025590 Q8VHQ9 Thea uc008tyw.1 uc008tyw.2 uc008tyw.3 uc008tyw.4 Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway. Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence=; Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=; Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence=; Reaction=butanoyl-CoA + H2O = butanoate + CoA + H(+); Xref=Rhea:RHEA:40111, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40112; Evidence=; Lipid metabolism; fatty acid metabolism. Mitochondrion matrix Cytoplasm By cold exposure and repressed by heat exposure. fatty-acyl-CoA binding cytoplasm mitochondrion mitochondrial matrix cytosol lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process lipid binding response to temperature stimulus response to cold palmitoyl-CoA hydrolase activity hydrolase activity thiolester hydrolase activity intracellular signal transduction long-chain fatty acyl-CoA binding acyl-CoA hydrolase activity carboxylic ester hydrolase activity long-chain acyl-CoA hydrolase activity uc008tyw.1 uc008tyw.2 uc008tyw.3 uc008tyw.4 
ENSMUST00000102763.5 Cdkn2aipnl ENSMUST00000102763.5 CDKN2A interacting protein N-terminal like (from RefSeq NM_029976.3) B1AU49 C2AIL_MOUSE D11Ertd497e ENSMUST00000102763.1 ENSMUST00000102763.2 ENSMUST00000102763.3 ENSMUST00000102763.4 MNCb-1520 NM_029976 Q9D211 uc007ius.1 uc007ius.2 uc007ius.3 uc007ius.4 Interacts with XRN2; the interaction is direct. Belongs to the CARF family. molecular_function nucleoplasm nucleolus uc007ius.1 uc007ius.2 uc007ius.3 uc007ius.4 
ENSMUST00000102765.9 Col23a1 ENSMUST00000102765.9 collagen, type XXIII, alpha 1 (from RefSeq NM_153393.2) CONA1_MOUSE ENSMUST00000102765.1 ENSMUST00000102765.2 ENSMUST00000102765.3 ENSMUST00000102765.4 ENSMUST00000102765.5 ENSMUST00000102765.6 ENSMUST00000102765.7 ENSMUST00000102765.8 NM_153393 Q5SUQ0 Q8K4G2 uc033fvk.1 uc033fvk.2 uc033fvk.3 Homotrimer. Cell membrane ; Single-pass type II membrane protein ; Extracellular side Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms a homotrimer and exhibits a low affinity interaction with heparin. extracellular matrix structural constituent extracellular region collagen trimer collagen type IV trimer extracellular space plasma membrane heparin binding cell surface membrane integral component of membrane extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix identical protein binding protein homodimerization activity protein homotrimerization uc033fvk.1 uc033fvk.2 uc033fvk.3 
ENSMUST00000102766.10 Zfp354a ENSMUST00000102766.10 zinc finger protein 354A, transcript variant 1 (from RefSeq NM_009329.4) ENSMUST00000102766.1 ENSMUST00000102766.2 ENSMUST00000102766.3 ENSMUST00000102766.4 ENSMUST00000102766.5 ENSMUST00000102766.6 ENSMUST00000102766.7 ENSMUST00000102766.8 ENSMUST00000102766.9 Kid1 NM_009329 Q61751 Q9QXU0 Tcf17 Z354A_MOUSE Znf354a uc007itl.1 uc007itl.2 uc007itl.3 uc007itl.4 It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. Nucleus. Highly expressed in eye and kidney. Detected at high levels in adult brain and kidney, and at lower levels in adult liver, lung, skeletal muscle, heart, salivary gland, testis and tongue. Detected in embryonic brain, heart, lung,kidney and gut. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleolus cytosol regulation of transcription, DNA-templated multicellular organism development nucleolar fragmentation metal ion binding uc007itl.1 uc007itl.2 uc007itl.3 uc007itl.4 
ENSMUST00000102768.8 Rbm43 ENSMUST00000102768.8 RNA binding motif protein 43, transcript variant 1 (from RefSeq NM_030243.5) ENSMUST00000102768.1 ENSMUST00000102768.2 ENSMUST00000102768.3 ENSMUST00000102768.4 ENSMUST00000102768.5 ENSMUST00000102768.6 ENSMUST00000102768.7 NM_030243 Q99J64 RBM43_MOUSE uc289wbw.1 uc289wbw.2 molecular_function nucleic acid binding RNA binding cellular_component biological_process uc289wbw.1 uc289wbw.2 
ENSMUST00000102769.11 Mmadhc ENSMUST00000102769.11 methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria, transcript variant 1 (from RefSeq NM_133839.3) ENSMUST00000102769.1 ENSMUST00000102769.10 ENSMUST00000102769.2 ENSMUST00000102769.3 ENSMUST00000102769.4 ENSMUST00000102769.5 ENSMUST00000102769.6 ENSMUST00000102769.7 ENSMUST00000102769.8 ENSMUST00000102769.9 MMAD_MOUSE Mmadhc NM_133839 Q99LS1 uc008jqc.1 uc008jqc.2 uc008jqc.3 Involved in cobalamin metabolism and trafficking. Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Heterodimer with MMACHC. Forms a multiprotein complex with MMACHC, MTR and MTRR. Cytoplasm Mitochondrion molecular_function cytoplasm mitochondrion coenzyme biosynthetic process cobalamin metabolic process uc008jqc.1 uc008jqc.2 uc008jqc.3 
ENSMUST00000102772.4 Ltc4s ENSMUST00000102772.4 leukotriene C4 synthase, transcript variant 3 (from RefSeq NR_132732.1) ENSMUST00000102772.1 ENSMUST00000102772.2 ENSMUST00000102772.3 LTC4S_MOUSE NR_132732 Q5SVR7 Q60860 Q9QVS1 uc007isa.1 uc007isa.2 uc007isa.3 uc007isa.4 The protein encoded by this gene is an enzyme that catalyzes the synthesis of leukotriene C4 by combining leukotriene A4 with reduced glutathione. The encoded protein is found in the outer nuclear membrane and in the peripheral endoplasmic reticulum. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as bronchial asthma in humans. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:8706658, PubMed:11319240). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy- docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti- inflammatory and proresolving actions (By similarity). Reaction=leukotriene C4 = glutathione + leukotriene A4; Xref=Rhea:RHEA:17617, ChEBI:CHEBI:57463, ChEBI:CHEBI:57925, ChEBI:CHEBI:57973; EC=4.4.1.20; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17619; Evidence=; Reaction=(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy- (4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate; Xref=Rhea:RHEA:53508, ChEBI:CHEBI:57925, ChEBI:CHEBI:131958, ChEBI:CHEBI:137407; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53509; Evidence=; Inhibited by MK886. Kinetic parameters: KM=10.3 uM for leukotriene A4 ; KM=1.9 uM for glutathione ; Vmax=2.3 umol/min/mg enzyme with leukotriene A4 as substrate ; Vmax=2.2 umol/min/mg enzyme with glutathione as substrate ; Lipid metabolism; leukotriene C4 biosynthesis. Homotrimer. Interacts with ALOX5AP and ALOX5. Nucleus outer membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Nucleus membrane ; Multi-pass membrane protein Widely expressed. Phosphorylation at Ser-36 by RPS6KB1 inhibits the leukotriene-C4 synthase activity. Deficient mice developed normally and are fertile. However mice display abnormal inflammatory and hypersensitivity reactions. Belongs to the MAPEG family. glutathione transferase activity leukotriene-C4 synthase activity glutathione peroxidase activity nucleus nuclear envelope nuclear outer membrane endoplasmic reticulum endoplasmic reticulum membrane leukotriene metabolic process enzyme activator activity lipid binding membrane integral component of membrane lyase activity leukotriene biosynthetic process identical protein binding positive regulation of catalytic activity intracellular membrane-bounded organelle glutathione binding protein heterodimerization activity cellular oxidant detoxification uc007isa.1 uc007isa.2 uc007isa.3 uc007isa.4 
ENSMUST00000102774.11 Sqstm1 ENSMUST00000102774.11 sequestosome 1, transcript variant 1 (from RefSeq NM_011018.3) A170 ENSMUST00000102774.1 ENSMUST00000102774.10 ENSMUST00000102774.2 ENSMUST00000102774.3 ENSMUST00000102774.4 ENSMUST00000102774.5 ENSMUST00000102774.6 ENSMUST00000102774.7 ENSMUST00000102774.8 ENSMUST00000102774.9 NM_011018 Q64337 Q99JM8 SQSTM_MOUSE STAP uc007irw.1 uc007irw.2 uc007irw.3 uc007irw.4 Autophagy receptor required for selective macroautophagy (aggrephagy) (By similarity). Functions as a bridge between polyubiquitinated cargo and autophagosomes (By similarity). Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (By similarity). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures) (By similarity). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (By similarity). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (By similarity). May play a role in titin/TTN downstream signaling in muscle cells (By similarity). May regulate signaling cascades through ubiquitination (By similarity). Adapter that mediates the interaction between TRAF6 and CYLD (PubMed:14960283, PubMed:18382763). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels (By similarity). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (By similarity). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (By similarity). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20421418, PubMed:20173742, PubMed:24011591). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (By similarity). Homooligomer or heterooligomer; may form homotypic arrays (PubMed:20173742). Interacts directly with PRKCI and PRKCZ (Probable). Interacts with EBI3, LCK, RASA1, PRKCZ, PRKCI, NR2F2, NTRK1, NTRK2, NTRK3, NBR1, MAP2K5, TRIM13, TRIM55 and MAPKAPK5. Interacts with the proteasome subunits PSMD4 and PSMC2. Interacts with K63- polyubiquitinated MAPT/TAU. Interacts with IKBKB through PRKCZ and PRKCI. Interacts with NGFR through TRAF6 and bridges that complex to NTRK1. Forms a complex with MAP2K5 and PRKCZ or PRKCI. Component of a ternary complex with PAWR and PRKCZ. Upon TNF-alpha stimulation, interacts with RIPK1 probably bridging IKBKB to the TNF-R1 complex composed of TNF-R1/TNFRSF1A, TRADD and RIPK1. Forms a complex with AJUBA, PRKCZ and TRAF6. Forms ternary complexes with PRKCZ and KCNAB2 or PRKCZ and GABBR3. Interacts with KCNAB1, GABRR1, GABRR2 and GABRR3. Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6. Identified in a heterotrimeric complex with ubiquitin and ZFAND5, where ZFAND5 and SQSTM1 both interact with the same ubiquitin molecule (By similarity). Interacts with TRAF6 and CYLD. Identified in a complex with TRAF6 and CYLD. Directly interacts with MAP1LC3A and MAP1LC3B, as well as with other MAP1 LC3 family members, including GABARAP, GABARAPL1 and GABARAPL2; these interactions are necessary for the recruitment MAP1 LC3 family members to inclusion bodies containing polyubiquitinated protein aggregates and for their degradation by autophagy (By similarity). Interacts with FHOD3 (By similarity). Interacts with TRMI5 (By similarity). Interacts with SESN1 (By similarity). Interacts with SESN2 (PubMed:25040165). Interacts with ULK1 (PubMed:25040165). Interacts with UBD (By similarity). Interacts with WDR81; the interaction is direct and regulates the interaction of SQSTM1 with ubiquitinated proteins (By similarity). Interacts with WDFY3; this interaction is required to recruit WDFY3 to cytoplasmic bodies and to PML bodies (By similarity). Interacts with TRIM23 (By similarity). Interacts with LRRC25. Interacts with TRIM50 (PubMed:22792322). Interacts with TRIM16 (By similarity). Interacts with STING1; leading to relocalization of STING1 to autophagosomes (By similarity). Interacts (when phosphorylated at Ser-351) with KEAP1; the interaction is direct and inactivates the BCR(KEAP1) complex by sequestering KEAP1 in inclusion bodies, promoting its degradation (PubMed:20495340, PubMed:20421418, PubMed:20173742). Interacts with GBP1 (PubMed:21551061). Interacts with MOAP1; promoting dissociation of SQSTM1 inclusion bodies that sequester KEAP1 (By similarity). Interacts with TAX1BP1 (By similarity). Interacts with (ubiquitinated) PEX5; specifically binds PEX5 ubiquitinated at 'Lys-209' in response to reactive oxygen species (ROS) (By similarity). Interacts (via PB1 domain) with TNS2; the interaction leads to sequestration of TNS2 in cytoplasmic aggregates with SQSTM1 and promotes TNS2 ubiquitination and proteasomal degradation (By similarity). Interacts with IRS1; the interaction is disrupted by the presence of tensin TNS2 (By similarity). Interacts with TRIM11 (when ubiquitinated); promoting AIM2 recruitment to autophagosomes and autophagy-dependent degradation of AIM2 (By similarity). Interacts with ECSIT; this interaction inhibits TLR4 signaling via functional regulation of the TRAF6-ECSIT complex (By similarity). Q64337; Q9Z2X8: Keap1; NbExp=6; IntAct=EBI-645025, EBI-647110; Q64337; Q9WVS7: Map2k5; NbExp=3; IntAct=EBI-645025, EBI-446144; Q64337; P28700: Rxra; NbExp=3; IntAct=EBI-645025, EBI-346715; Q64337; P48281: Vdr; NbExp=3; IntAct=EBI-645025, EBI-346797; Q64337; Q14145: KEAP1; Xeno; NbExp=2; IntAct=EBI-645025, EBI-751001; Q64337; Q9GZQ8: MAP1LC3B; Xeno; NbExp=6; IntAct=EBI-645025, EBI-373144; Cytoplasm, cytosol eautophagosomal structure Late endosome Nucleus Endoplasmic reticulum Lysosome Cytoplasmic vesicle, autophagosome Nucleus, PML body Cytoplasm, myofibril, sarcomere. Note=In cardiac muscles, localizes to the sarcomeric band (By similarity). May also localize to the hepatocellular carcinoma (By similarity). Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates (PubMed:20421418). Co- localizes with TRIM5 in the cytoplasmic bodies (By similarity). When nuclear export is blocked by treatment with leptomycin B, accumulates in PML bodies (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q64337-1; Sequence=Displayed; Name=2; IsoId=Q64337-2; Sequence=VSP_015842; Widely expressed. By diethylmaleate, paraquat, menadione, sodium arsenite and cadmium chloride, arsenite and arsenate. By MG132, MG115, lactacystin and proteasome inhibitor I (PSI). By serum starvation, okadaic acid and glucose oxidase. Also up-regulated by RANK-L (at protein level). By etoposide and trichostatin. By the parkinsonian mimetic 6- hydroxydopamine (6-OHDA). By TGF-beta. The UBA domain binds specifically 'Lys-63'-linked polyubiquitin chains of polyubiquitinated substrates. Mediates the interaction with TRIM55. Both the UBA and PB1 domains are necessary and sufficient for the localization into the ubiquitin-containing inclusion bodies. The PB1 domain mediates homooligomerization and interactions with FHOD3, MAP2K5, NBR1, PRKCI, PRKCZ and WDR81. Both the PB1 and UBA domains are necessary and sufficient for the localization into the ubiquitin-containing inclusion bodies. The ZZ-type zinc finger mediates the interaction with RIPK1. The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins. Phosphorylated. May be phosphorylated by PRKCZ. Phosphorylated in vitro by TTN (By similarity). Phosphorylation at Ser-405 by ULK1 is stimulated by SESN2 (By similarity). Phosphorylated at Ser-405 by TBK1, leading to promote relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (By similarity). Phosphorylation at Ser-351 by MTOR promotes interaction with KEAP1 and inactivation of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:24011591). Ubiquitinated by UBE2J1 and RNF26 at Lys-437: ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Deubiquitination by USP15 releases target vesicles for fast transport into the cell periphery. Ubiquitinated by the BCR(KEAP1) complex at Lys-422, increasing SQSTM1 sequestering activity and promoting its degradation. Ubiquitinated via 'Lys-29' and 'Lys-33'-linked polyubiquitination leading to xenophagic targeting of bacteria and inhibition of their replication. Impaired induced osteoclastogenesis. negative regulation of transcription from RNA polymerase II promoter pre-autophagosomal structure macromitophagy P-body positive regulation of protein phosphorylation immune system process response to ischemia transcription cofactor activity protein kinase C binding protein binding nucleus cytoplasm mitochondrion lysosome endosome late endosome autophagosome endoplasmic reticulum cytosol autophagy apoptotic process mitochondrion organization endosome organization zinc ion binding inclusion body aggresome macroautophagy PML body enzyme binding protein kinase binding sarcomere cell differentiation cytoplasmic vesicle ubiquitin protein ligase binding ionotropic glutamate receptor binding aggrephagy SH2 domain binding identical protein binding protein homodimerization activity regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding intracellular membrane-bounded organelle amphisome autolysosome metal ion binding protein heterooligomerization regulation of protein complex stability K63-linked polyubiquitin binding sperm midpiece Lewy body response to mitochondrial depolarisation positive regulation of long-term synaptic potentiation positive regulation of protein localization to plasma membrane protein localization to perinuclear region of cytoplasm uc007irw.1 uc007irw.2 uc007irw.3 uc007irw.4 
ENSMUST00000102776.5 Rnf130 ENSMUST00000102776.5 ring finger protein 130, transcript variant 1 (from RefSeq NM_021540.4) ENSMUST00000102776.1 ENSMUST00000102776.2 ENSMUST00000102776.3 ENSMUST00000102776.4 G1rp GOLI_MOUSE NM_021540 Q80VL7 Q8VEM1 Q9QZQ6 Rnf130 uc007irl.1 uc007irl.2 uc007irl.3 uc007irl.4 Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Membrane ; Single-pass type I membrane protein Cytoplasm Expression is highest in liver, with lesser amounts in the lung, spleen, brain, heart, kidney and testis. Up-regulated in response to interleukin-3 (IL-3) withdrawal- induced apoptosis of 32Dcl3 cells (derived from bone marrow). molecular_function ubiquitin-protein transferase activity cytoplasm ubiquitin-dependent protein catabolic process apoptotic process programmed cell death membrane integral component of membrane protein ubiquitination transferase activity metal ion binding ubiquitin protein ligase activity uc007irl.1 uc007irl.2 uc007irl.3 uc007irl.4 
ENSMUST00000102780.8 Ak4 ENSMUST00000102780.8 adenylate kinase 4, transcript variant 3 (from RefSeq NM_001177605.1) Ak-4 Ak3b Ak3l1 ENSMUST00000102780.1 ENSMUST00000102780.2 ENSMUST00000102780.3 ENSMUST00000102780.4 ENSMUST00000102780.5 ENSMUST00000102780.6 ENSMUST00000102780.7 KAD4_MOUSE NM_001177605 Q9R1X7 Q9WUR9 uc008tvp.1 uc008tvp.2 uc008tvp.3 uc008tvp.4 Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular response to oxidative stress (By similarity). Reaction=a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'- diphosphate + ADP; Xref=Rhea:RHEA:13749, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.10; Evidence=; Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence= Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Monomer (By similarity). Interacts with SLC25A5/ANT2 (By similarity). Mitochondrion matrix Expressed in kidney, liver, stomach, brain, spinal cord, heart, ovary, oviduct, colon, jejunum, ileum and testis (at protein level) (PubMed:19492028, PubMed:19130895). In the brain, expressed in the pyramidal cells of the cerebrum and glial cells in the cerebellum (at protein level) (PubMed:19492028). In the heart, expressed by myocytes (at protein level) (PubMed:19492028). In the kidney, expressed in the proximal to distal tubule in the cortex and the outer and inner zones of the medulla (at protein level) (PubMed:19492028). In the stomach, expressed in stratified squamous epithelia in the forestomach and in the gastric pit and mucus producing cells of the glandular stomach (at protein level) (PubMed:19492028). Expressed in epithelial cells of the jejunum, ileum, and colon (at protein level) (PubMed:19492028). In the testis, expressed by spermatocytes (at protein level) (PubMed:19492028). In the ovaries, expressed by oocytes, follicular epithelial cells, and corpus luteum cells (at protein level) (PubMed:19492028). In the oviduct, expressed in the epithelia of the isthmus and the ciliated cells of the ampulla (at protein level) (PubMed:19492028). Expressed in the pyramidal cells in the hippocampus (PubMed:9813319). Expressed in the central nervous system in a region-specific manner from the middle stage of embryogenesis to the adulthood in the rodent. Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis. Belongs to the adenylate kinase family. AK3 subfamily. nucleotide binding liver development regulation of oxidative phosphorylation adenylate kinase activity nucleoside diphosphate kinase activity ATP binding GTP binding mitochondrion mitochondrial matrix nucleobase-containing compound metabolic process nucleoside diphosphate phosphorylation ADP biosynthetic process brain development nucleoside triphosphate biosynthetic process kinase activity phosphorylation transferase activity phosphotransferase activity, phosphate group as acceptor nucleobase-containing compound kinase activity response to drug AMP metabolic process ATP metabolic process GTP metabolic process nucleoside triphosphate adenylate kinase activity nucleoside monophosphate phosphorylation cellular response to hypoxia regulation of ATP biosynthetic process uc008tvp.1 uc008tvp.2 uc008tvp.3 uc008tvp.4 
ENSMUST00000102781.10 Jak1 ENSMUST00000102781.10 Janus kinase 1, transcript variant 1 (from RefSeq NM_146145.2) B1ASP2 B1ASP2_MOUSE ENSMUST00000102781.1 ENSMUST00000102781.2 ENSMUST00000102781.3 ENSMUST00000102781.4 ENSMUST00000102781.5 ENSMUST00000102781.6 ENSMUST00000102781.7 ENSMUST00000102781.8 ENSMUST00000102781.9 Jak1 NM_146145 uc008tvk.1 uc008tvk.2 uc008tvk.3 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Endomembrane system ; Peripheral membrane protein Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity growth hormone receptor binding ATP binding nucleus cytoplasm cytoskeleton protein phosphorylation membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation protein phosphatase binding ubiquitin protein ligase binding CCR5 chemokine receptor binding intracellular signal transduction interleukin-2-mediated signaling pathway response to antibiotic positive regulation of sprouting angiogenesis uc008tvk.1 uc008tvk.2 uc008tvk.3 
ENSMUST00000102782.4 Rpl35rt ENSMUST00000102782.4 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). (from UniProt Q6ZWV7) BC125652 ENSMUST00000102782.1 ENSMUST00000102782.2 ENSMUST00000102782.3 Q6ZWV7 RL35_MOUSE Rpl35 uc287mva.1 uc287mva.2 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Cytoplasm Belongs to the universal ribosomal protein uL29 family. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) mRNA binding structural constituent of ribosome ribosome translation cytosolic large ribosomal subunit ribonucleoprotein complex binding uc287mva.1 uc287mva.2 
ENSMUST00000102787.10 Dennd1a ENSMUST00000102787.10 DENN domain containing 1A, transcript variant 2 (from RefSeq NM_146122.3) A0MCI0 A2ALU2 DEN1A_MOUSE ENSMUST00000102787.1 ENSMUST00000102787.2 ENSMUST00000102787.3 ENSMUST00000102787.4 ENSMUST00000102787.5 ENSMUST00000102787.6 ENSMUST00000102787.7 ENSMUST00000102787.8 ENSMUST00000102787.9 NM_146122 Q8K382 uc008jng.1 uc008jng.2 uc008jng.3 uc008jng.4 Guanine nucleotide exchange factor (GEF) regulating clathrin- mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP- bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:17182770, PubMed:20159556). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (PubMed:20159556). The guanine nucleotide exchange factor (GEF) activity is autoinhibited. Autoinhibition may be the result of intramolecular interaction between the DENN domain and the C-terminus, which is disrupted upon phosphorylation. Activation is regulated by Akt activation. Interacts with RAB35 (PubMed:20159556). Interacts with clathrin and with the adapter protein complex 2, AP-2 (By similarity). Interacts with ITSN1 and SH3GL2 (PubMed:17182770). Interacts (when phosphorylated) with YWHAE (By similarity). Q8K382; Q9Z0R4: Itsn1; NbExp=3; IntAct=EBI-7186684, EBI-645386; Q8K382; Q62420: Sh3gl2; NbExp=2; IntAct=EBI-7186684, EBI-77971; Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein esynaptic cell membrane Note=Associates to membranes via lipid- binding activity. Phosphorylated on serine and/or threonine in an Akt-dependent manner. Phosphorylation probably regulates the guanine nucleotide exchange factor (GEF) activity, possibly by disrupting an intramolecular interaction between the DENN domain and the C-terminus of the protein, thereby relieving the autoinhibition. guanyl-nucleotide exchange factor activity protein binding nucleoplasm cytosol plasma membrane endocytosis lipid binding protein transport membrane Rab guanyl-nucleotide exchange factor activity SH3 domain binding Rab GTPase binding cell junction clathrin-coated vesicle dendrite clathrin-coated vesicle membrane cytoplasmic vesicle phosphatidylinositol-3-phosphate binding endocytic recycling regulation of Rab protein signal transduction presynaptic membrane neuronal cell body intracellular membrane-bounded organelle positive regulation of GTPase activity synapse synaptic vesicle endocytosis phosphatidylinositol phosphate binding uc008jng.1 uc008jng.2 uc008jng.3 uc008jng.4 
ENSMUST00000102790.4 Kank4 ENSMUST00000102790.4 KN motif and ankyrin repeat domains 4 (from RefSeq NM_172872.3) Ankrd38 ENSMUST00000102790.1 ENSMUST00000102790.2 ENSMUST00000102790.3 KANK4_MOUSE NM_172872 Q6P9J5 Q8BV03 uc008tuk.1 uc008tuk.2 uc008tuk.3 uc008tuk.4 May be involved in the control of cytoskeleton formation by regulating actin polymerization. Cytoplasm molecular_function cytoplasm cytosol microtubule cytoskeleton negative regulation of actin filament polymerization negative regulation of stress fiber assembly uc008tuk.1 uc008tuk.2 uc008tuk.3 uc008tuk.4 
ENSMUST00000102793.11 Tm2d1 ENSMUST00000102793.11 TM2 domain containing 1 (from RefSeq NM_053157.2) A2ADR1 A2ADR4 Bbp ENSMUST00000102793.1 ENSMUST00000102793.10 ENSMUST00000102793.2 ENSMUST00000102793.3 ENSMUST00000102793.4 ENSMUST00000102793.5 ENSMUST00000102793.6 ENSMUST00000102793.7 ENSMUST00000102793.8 ENSMUST00000102793.9 NM_053157 Q99MB3 TM2D1_MOUSE uc033idg.1 uc033idg.2 uc033idg.3 May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42. Interacts with APP beta-APP42 (amyloid-beta protein 42). Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99MB3-1; Sequence=Displayed; Name=2; IsoId=Q99MB3-2; Sequence=VSP_027494; N-glycosylated. Belongs to the TM2 family. Sequence=AK009511; Type=Frameshift; Evidence=; Sequence=CAM26981.1; Type=Erroneous gene model prediction; Evidence=; beta-amyloid binding G-protein coupled receptor activity nucleoplasm integral component of plasma membrane apoptotic process G-protein coupled receptor signaling pathway membrane integral component of membrane apoptotic signaling pathway uc033idg.1 uc033idg.2 uc033idg.3 
ENSMUST00000102794.8 Ggta1 ENSMUST00000102794.8 glycoprotein galactosyltransferase alpha 1, 3, transcript variant 1 (from RefSeq NM_010283.5) ENSMUST00000102794.1 ENSMUST00000102794.2 ENSMUST00000102794.3 ENSMUST00000102794.4 ENSMUST00000102794.5 ENSMUST00000102794.6 ENSMUST00000102794.7 Ggta1 NM_010283 Q9DBU1 Q9DBU1_MOUSE uc008jkk.1 uc008jkk.2 uc008jkk.3 uc008jkk.4 uc008jkk.5 This gene encodes a member of the galactosyltransferase family of intracellular, membrane-bound enzymes that are involved in the biosynthesis of glycoproteins and glycolipids. The encoded protein catalyzes the transfer of galactose from UDP-galactose to N-acetyllactosamine in an alpha(1,3) linkage to form galactose alpha(1,3)-galactose. Mice lacking the encoded protein develop cortical cataracts. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]. Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)- beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:13013, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:133507, ChEBI:CHEBI:138024; EC=2.4.1.87; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mn(2+) ion per subunit. ; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 6 family. carbohydrate metabolic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups Golgi cisterna protein galactosylation at cell surface uc008jkk.1 uc008jkk.2 uc008jkk.3 uc008jkk.4 uc008jkk.5 
ENSMUST00000102795.4 Ublcp1 ENSMUST00000102795.4 ubiquitin-like domain containing CTD phosphatase 1 (from RefSeq NM_024475.5) A2ACX3 ENSMUST00000102795.1 ENSMUST00000102795.2 ENSMUST00000102795.3 NM_024475 Q52L62 Q5XJH1 Q6PH96 Q8BGR9 Q99LT3 UBCP1_MOUSE uc007ing.1 uc007ing.2 uc007ing.3 uc007ing.4 Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1. Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly. Has also been reported to stimulate the proteolytic activity of the 26S proteasome. Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Nucleus Note=Colocalizes with nuclear proteasomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGR9-1; Sequence=Displayed; Name=2; IsoId=Q8BGR9-2; Sequence=VSP_019458; The Ubiquitin-like domain mediates interaction with proteasomes. phosphoprotein phosphatase activity protein serine/threonine phosphatase activity nucleus nucleolus protein dephosphorylation hydrolase activity uc007ing.1 uc007ing.2 uc007ing.3 uc007ing.4 
ENSMUST00000102796.10 Il12b ENSMUST00000102796.10 interleukin 12b (from RefSeq NM_001303244.1) ENSMUST00000102796.1 ENSMUST00000102796.2 ENSMUST00000102796.3 ENSMUST00000102796.4 ENSMUST00000102796.5 ENSMUST00000102796.6 ENSMUST00000102796.7 ENSMUST00000102796.8 ENSMUST00000102796.9 IL12B Il12b NM_001303244 Q3ZAX5 Q3ZAX5_MOUSE uc007inc.1 uc007inc.2 uc007inc.3 uc007inc.4 This gene encodes the beta subunit p40 of the Interleukin 12 (IL-12) family of cytokines. Members of the IL-12 family form heterodimers consisting of heavy and light subunits linked by disulfide bonds. The product of this gene, p40, is a subunit of interleukins IL-12 and IL-23. [provided by RefSeq, Dec 2014]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M86671.1, AK162981.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Secreted Belongs to the IL-12B family. positive regulation of defense response to virus by host natural killer cell activation involved in immune response positive regulation of T-helper 1 type immune response positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target cytokine receptor activity cytokine activity extracellular region extracellular space cell cycle arrest growth factor activity response to UV-B positive regulation of activation of Janus kinase activity membrane cell migration cytokine-mediated signaling pathway sensory perception of pain natural killer cell activation negative regulation of interleukin-10 production negative regulation of interleukin-17 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell activation positive regulation of natural killer cell proliferation positive regulation of mononuclear cell proliferation positive regulation of smooth muscle cell apoptotic process T-helper cell differentiation positive regulation of T cell proliferation positive regulation of activated T cell proliferation interleukin-12 alpha subunit binding regulation of tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein identical protein binding interleukin-12 complex interleukin-23 receptor binding positive regulation of osteoclast differentiation positive regulation of cell adhesion protein heterodimerization activity negative regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation defense response to Gram-negative bacterium positive regulation of NK T cell activation positive regulation of NK T cell proliferation interleukin-23 complex uc007inc.1 uc007inc.2 uc007inc.3 uc007inc.4 
ENSMUST00000102798.8 Tek ENSMUST00000102798.8 TEK receptor tyrosine kinase, transcript variant 1 (from RefSeq NM_013690.3) B1AWS8 B1AWS8_MOUSE ENSMUST00000102798.1 ENSMUST00000102798.2 ENSMUST00000102798.3 ENSMUST00000102798.4 ENSMUST00000102798.5 ENSMUST00000102798.6 ENSMUST00000102798.7 NM_013690 Tek uc008tsj.1 uc008tsj.2 uc008tsj.3 uc008tsj.4 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Membrane ; Single- pass type I membrane protein Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Lacks conserved residue(s) required for the propagation of feature annotation. nucleotide binding response to hypoxia stress fiber positive regulation of protein phosphorylation endochondral ossification sprouting angiogenesis protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding microtubule organizing center actin filament plasma membrane integral component of plasma membrane microvillus cell-cell junction protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway basal plasma membrane cell surface response to organic substance positive regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane kinase activity phosphorylation basolateral plasma membrane apical plasma membrane negative regulation of angiogenesis transferase activity peptidyl-tyrosine phosphorylation growth factor binding regulation of establishment or maintenance of cell polarity substrate adhesion-dependent cell spreading response to peptide hormone positive regulation of phosphatidylinositol 3-kinase activity response to estrogen membrane raft positive regulation of angiogenesis protein autophosphorylation Tie signaling pathway protein oligomerization response to cAMP positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade glomerulus vasculature development positive regulation of intracellular signal transduction positive regulation of actin cytoskeleton reorganization uc008tsj.1 uc008tsj.2 uc008tsj.3 uc008tsj.4 
ENSMUST00000102800.9 Gapvd1 ENSMUST00000102800.9 GTPase activating protein and VPS9 domains 1, transcript variant 3 (from RefSeq NR_151469.1) A0PJI8 A2AR09 A2AR10 A2AR17 A2AR18 ENSMUST00000102800.1 ENSMUST00000102800.2 ENSMUST00000102800.3 ENSMUST00000102800.4 ENSMUST00000102800.5 ENSMUST00000102800.6 ENSMUST00000102800.7 ENSMUST00000102800.8 GAPD1_MOUSE Gapex5 Kiaa1521 NR_151469 Q3TNS1 Q3UDL0 Q3UYD5 Q6PAR5 Q6ZPP0 Q80V37 Q80ZK4 Q8BTS5 Q9CRS2 Q9CTI1 uc008jiq.1 uc008jiq.2 uc008jiq.3 uc008jiq.4 uc008jiq.5 Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. Interacts with RAB5A (By similarity). Interacts with TRIP10/CIP4. Membrane ; Peripheral membrane protein Endosome Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q6PAR5-1; Sequence=Displayed; Name=2; IsoId=Q6PAR5-2; Sequence=VSP_032366; Name=3; IsoId=Q6PAR5-3; Sequence=VSP_032363, VSP_032364; Name=4; IsoId=Q6PAR5-4; Sequence=VSP_032365, VSP_032366; Name=5; IsoId=Q6PAR5-5; Sequence=VSP_032366, VSP_032368; Name=6; IsoId=Q6PAR5-6; Sequence=VSP_032367; Present in adipocytes and fibroblasts (at protein level). Ubiquitously expressed. Belongs to the GAPVD1 family. Sequence=AAH31478.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH43715.1; Type=Erroneous initiation; Evidence=; Sequence=AAH48847.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH57164.1; Type=Erroneous initiation; Evidence=; Sequence=BAB29377.2; Type=Erroneous initiation; Evidence=; Sequence=BAC98191.1; Type=Erroneous initiation; Evidence=; Sequence=BAE22277.1; Type=Erroneous initiation; Evidence=; Sequence=BAE29251.1; Type=Frameshift; Evidence=; Sequence=CAM15445.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM15446.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM15455.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM15456.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM24604.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM24605.1; Type=Erroneous gene model prediction; Evidence=; guanyl-nucleotide exchange factor activity GTPase activator activity protein binding endosome cytosol endocytosis signal transduction membrane GTPase activating protein binding regulation of GTPase activity positive regulation of GTPase activity regulation of protein transport uc008jiq.1 uc008jiq.2 uc008jiq.3 uc008jiq.4 uc008jiq.5 
ENSMUST00000102801.8 Tenm2 ENSMUST00000102801.8 Cell membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein (from UniProt A0A0A0MQB7) A0A0A0MQB7 A0A0A0MQB7_MOUSE AB025411 ENSMUST00000102801.1 ENSMUST00000102801.2 ENSMUST00000102801.3 ENSMUST00000102801.4 ENSMUST00000102801.5 ENSMUST00000102801.6 ENSMUST00000102801.7 Tenm2 uc007ilk.1 uc007ilk.2 uc007ilk.3 uc007ilk.4 Cell membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein Belongs to the tenascin family. Teneurin subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. integral component of plasma membrane signal transduction membrane integral component of membrane uc007ilk.1 uc007ilk.2 uc007ilk.3 uc007ilk.4 
ENSMUST00000102803.11 Myh7 ENSMUST00000102803.11 myosin, heavy polypeptide 7, cardiac muscle, beta, transcript variant 1 (from RefSeq NM_080728.3) ENSMUST00000102803.1 ENSMUST00000102803.10 ENSMUST00000102803.2 ENSMUST00000102803.3 ENSMUST00000102803.4 ENSMUST00000102803.5 ENSMUST00000102803.6 ENSMUST00000102803.7 ENSMUST00000102803.8 ENSMUST00000102803.9 MYH7_MOUSE NM_080728 Q3TGM2 Q3TZN2 Q91Z83 uc007txv.1 uc007txv.2 uc007txv.3 Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with ECPAS. Interacts (via C-terminus) with LRRC39. Cytoplasm, myofibril Cytoplasm, myofibril, sarcomere Note=Thick filaments of the myofibrils. Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Four skip residues (Skip1: Thr-1188, Skip2: Glu-1385, Skip3: Glu-1582 and Skip4: Gly-1807) introduce discontinuities in the coiled-coil heptad repeats. The first three skip residues are structurally comparable and induce a unique local relaxation of the coiled-coil superhelical pitch and the fourth skip residue lies within a highly flexible molecular hinge that is necessary for myosin incorporation in the bare zone of sarcomeres. The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7). microfilament motor activity nucleotide binding stress fiber regulation of the force of heart contraction regulation of heart rate skeletal muscle contraction motor activity actin binding calmodulin binding ATP binding cytoplasm muscle myosin complex muscle contraction striated muscle contraction adult heart development regulation of the force of skeletal muscle contraction transition between fast and slow fiber cardiac muscle hypertrophy in response to stress myosin complex ATPase activity myofibril sarcomere Z disc muscle filament sliding actin-dependent ATPase activity regulation of slow-twitch skeletal muscle fiber contraction myosin filament protein homodimerization activity ATP metabolic process protein heterodimerization activity actin filament binding ventricular cardiac muscle tissue morphogenesis cardiac muscle contraction uc007txv.1 uc007txv.2 uc007txv.3 
ENSMUST00000102804.2 Ifna5 ENSMUST00000102804.2 interferon alpha 5 (from RefSeq NM_010505.2) ENSMUST00000102804.1 If1ai12 Ifna5 NM_010505 Q810G2 Q810G2_MOUSE uc008toa.1 uc008toa.2 Secreted Belongs to the alpha/beta interferon family. cytokine activity cytokine receptor binding extracellular region extracellular space defense response signal transduction defense response to virus uc008toa.1 uc008toa.2 
ENSMUST00000102805.4 Cd200r2 ENSMUST00000102805.4 Cd200 receptor 2 (from RefSeq NM_206535.1) Cd200r1l ENSMUST00000102805.1 ENSMUST00000102805.2 ENSMUST00000102805.3 MO2R2_MOUSE NM_206535 Q6XJV6 uc007zhv.1 uc007zhv.2 According to PubMed:15187158 it is a receptor for the CD200 cell surface glycoprotein. According to PubMed:16081818 it is not a receptor for the CD200/OX2 cell surface glycoprotein. Involved in the recruitment or surface expression of the TYROBP receptor. Membrane ; Single-pass type I membrane protein Expressed in bone marrow, spleen, brain, lung, testis and thymus. Belongs to the CD200R family. protein binding external side of plasma membrane membrane integral component of membrane signaling receptor activity uc007zhv.1 uc007zhv.2 
ENSMUST00000102806.2 Ifna12 ENSMUST00000102806.2 interferon alpha 12 (from RefSeq NM_177361.2) ENSMUST00000102806.1 IFNAC_MOUSE NM_177361 Q80SS5 uc008tnd.1 uc008tnd.2 Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase (By similarity). Secreted Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tnd.1 uc008tnd.2 
ENSMUST00000102807.2 Ifna9 ENSMUST00000102807.2 interferon alpha 9 (from RefSeq NM_010507.1) ENSMUST00000102807.1 IFNA9_MOUSE Ifa9 NM_010507 P09235 uc008tnc.1 uc008tnc.2 Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Secreted. Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tnc.1 uc008tnc.2 
ENSMUST00000102808.2 Ifna14 ENSMUST00000102808.2 interferon alpha 14 (from RefSeq NM_206975.1) ENSMUST00000102808.1 If1ai2 Ifna14 NM_206975 Q810G3 Q810G3_MOUSE uc008tnb.1 uc008tnb.2 Secreted Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tnb.1 uc008tnb.2 
ENSMUST00000102809.2 Ifna15 ENSMUST00000102809.2 interferon alpha 15 (from RefSeq NM_206870.1) ENSMUST00000102809.1 Gm12597 If1ai1 Ifna15 MuIFN-alpha-A NM_206870 OTTMUSG00000007655 Q61718 Q61718_MOUSE uc008tna.1 uc008tna.2 Secreted Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tna.1 uc008tna.2 
ENSMUST00000102810.10 Garnl3 ENSMUST00000102810.10 GTPase activating RANGAP domain-like 3, transcript variant 3 (from RefSeq NM_178888.5) ENSMUST00000102810.1 ENSMUST00000102810.2 ENSMUST00000102810.3 ENSMUST00000102810.4 ENSMUST00000102810.5 ENSMUST00000102810.6 ENSMUST00000102810.7 ENSMUST00000102810.8 ENSMUST00000102810.9 GARL3_MOUSE NM_178888 Q3V0G7 Q8BNH8 Q8CC22 uc008jhi.1 uc008jhi.2 uc008jhi.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3V0G7-1; Sequence=Displayed; Name=2; IsoId=Q3V0G7-2; Sequence=VSP_029746, VSP_029747; Belongs to the GARNL3 family. Sequence=BAC38990.1; Type=Erroneous initiation; Evidence=; molecular_function GTPase activator activity biological_process intracellular membrane-bounded organelle positive regulation of GTPase activity regulation of small GTPase mediated signal transduction uc008jhi.1 uc008jhi.2 uc008jhi.3 
ENSMUST00000102813.2 Cfap157 ENSMUST00000102813.2 cilia and flagella associated protein 157 (from RefSeq NM_025619.1) CF157_MOUSE Cfap157 ENSMUST00000102813.1 NM_025619 Q0VFX2 Q9DA63 uc008jgz.1 uc008jgz.2 uc008jgz.3 Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility (PubMed:27965440). May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure (PubMed:27965440). Interacts with TUBB and TUBA4A (PubMed:27965440). Interacts with CEP350 (PubMed:27965440). Cytoplasm, cytoskeleton, cilium basal body Specifically expressed in tissues containing motile cilia. Expression is activated by FOXJ1. Mice were born at expected Mendelian ratios and appear normal but homozygous males are infertile. Spermatozoa display impaired motility due to defects in the axoneme. Sperm cells show an axonemal loop of the midpiece, supernumerary axonemes and a disrupted axonemal arrangement, as well as defective axonemes along the flagella. Belongs to the CFAP157 family. Sequence=BAB24421.1; Type=Frameshift; Evidence=; protein binding cytoplasm cytosol cytoskeleton plasma membrane cilium spermatogenesis sperm axoneme assembly microtubule binding cell differentiation ciliary basal body cell projection intracellular membrane-bounded organelle uc008jgz.1 uc008jgz.2 uc008jgz.3 
ENSMUST00000102814.5 Rps6 ENSMUST00000102814.5 ribosomal protein S6 (from RefSeq NM_009096.3) ENSMUST00000102814.1 ENSMUST00000102814.2 ENSMUST00000102814.3 ENSMUST00000102814.4 NM_009096 Q5BLK1 Q5BLK1_MOUSE Rps6 uc008tme.1 uc008tme.2 uc008tme.3 Belongs to the eukaryotic ribosomal protein eS6 family. structural constituent of ribosome nucleus nucleolus endoplasmic reticulum cytosol ribosome rRNA processing translation small ribosomal subunit protein kinase binding cytosolic small ribosomal subunit dendrite TOR signaling cytoplasmic ribonucleoprotein granule ribosomal small subunit biogenesis positive regulation of apoptotic process cell body ribonucleoprotein complex uc008tme.1 uc008tme.2 uc008tme.3 
ENSMUST00000102815.10 Ranbp17 ENSMUST00000102815.10 RAN binding protein 17, transcript variant 2 (from RefSeq NR_110973.2) ENSMUST00000102815.1 ENSMUST00000102815.2 ENSMUST00000102815.3 ENSMUST00000102815.4 ENSMUST00000102815.5 ENSMUST00000102815.6 ENSMUST00000102815.7 ENSMUST00000102815.8 ENSMUST00000102815.9 NR_110973 Q99NF8 Q9D4E3 RBP17_MOUSE uc007ikh.1 uc007ikh.2 uc007ikh.3 uc007ikh.4 May function as a nuclear transport receptor. Binds to nucleoporins and the GTP-bound form of Ran. Cytoplasm Nucleus Nucleus, nuclear pore complex Highly expressed in primary spermatocytes and very weakly in pancreas. Belongs to the exportin family. nuclear export signal receptor activity nucleus nuclear pore cytoplasm protein export from nucleus intracellular protein transport nucleocytoplasmic transport Ran GTPase binding protein transport mRNA transport uc007ikh.1 uc007ikh.2 uc007ikh.3 uc007ikh.4 
ENSMUST00000102817.5 Gap43 ENSMUST00000102817.5 growth associated protein 43 (from RefSeq NM_008083.2) Basp2 ENSMUST00000102817.1 ENSMUST00000102817.2 ENSMUST00000102817.3 ENSMUST00000102817.4 NEUM_MOUSE NM_008083 P06837 uc007zfv.1 uc007zfv.2 uc007zfv.3 uc007zfv.4 This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (PubMed:11433297). Interacts (via IQ domain) with calmodulin (PubMed:18493953). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity). Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, growth cone membrane ; Peripheral membrane protein ; Cytoplasmic side Synapse Cell projection, filopodium membrane ; Peripheral membrane protein Perikaryon Cell projection, dendrite Cell projection, axon Cytoplasm Note=Cytoplasmic surface of growth cone and synaptic plasma membranes. Expressed in the hippocampus (at protein level) (PubMed:18493953, PubMed:11573004). Expressed in the dorsal root ganglion and the spinal cord (at protein level) (PubMed:28111162). Up-regulated after memory training in radial arm maze experiments (PubMed:11573004). Up-regulated after sciatic nerve injury (PubMed:28111162). Phosphorylated (PubMed:18493953). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity). Palmitoylated by ZDHHC3 (PubMed:27875292). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 (By similarity). Belongs to the neuromodulin family. phosphatidylserine binding calmodulin binding cytoplasm plasma membrane multicellular organism development nervous system development axon guidance glial cell differentiation postsynaptic density membrane axon choice point recognition cell junction cell differentiation axon axon regeneration filopodium membrane growth cone membrane lysophosphatidic acid binding regulation of growth tissue regeneration cell projection cell fate commitment synapse regulation of filopodium assembly cell periphery GABA-ergic synapse phosphatidylinositol phosphate binding uc007zfv.1 uc007zfv.2 uc007zfv.3 uc007zfv.4 
ENSMUST00000102818.11 St6galnac4 ENSMUST00000102818.11 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4, transcript variant 1 (from RefSeq NM_011373.4) ENSMUST00000102818.1 ENSMUST00000102818.10 ENSMUST00000102818.2 ENSMUST00000102818.3 ENSMUST00000102818.4 ENSMUST00000102818.5 ENSMUST00000102818.6 ENSMUST00000102818.7 ENSMUST00000102818.8 ENSMUST00000102818.9 NM_011373 Q6PHP9 Q8C3J2 Q8C3J2_MOUSE St6galnac4 uc008jfy.1 uc008jfy.2 uc008jfy.3 uc008jfy.4 Reaction=a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41968, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568, ChEBI:CHEBI:78569; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41969; Evidence=; Membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 29 family. Golgi apparatus protein glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups sialylation uc008jfy.1 uc008jfy.2 uc008jfy.3 uc008jfy.4 
ENSMUST00000102819.10 Cntln ENSMUST00000102819.10 centlein, centrosomal protein, transcript variant 2 (from RefSeq NM_177385.5) A0PJC6 A2AM05 CNTLN_MOUSE Cntln ENSMUST00000102819.1 ENSMUST00000102819.2 ENSMUST00000102819.3 ENSMUST00000102819.4 ENSMUST00000102819.5 ENSMUST00000102819.6 ENSMUST00000102819.7 ENSMUST00000102819.8 ENSMUST00000102819.9 NM_177385 Q3TNP8 Q5EBN8 Q8C748 Q8C9U3 Q8CD25 Q8CE32 Q8R2F0 Q8R2P3 uc008tlk.1 uc008tlk.2 uc008tlk.3 uc008tlk.4 uc008tlk.5 Required for centrosome cohesion and recruitment of CEP68 to centrosomes. Interacts with CEP250 and CEP68. Interacts with NEK2; the interaction leads to phosphorylation of CNTLN. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Colocalizes with gamma-tubulin during interphase and mitosis. Appears to associate with the mother centriole during G1 phase and with daughter centrioles towards G1/S phase. Localizes to the proximal ends of the centrioles. Levels are high at interphase centrosomes but are reduced on mitotic spindle poles. Event=Alternative splicing; Named isoforms=4; Name=1 IsoId=A2AM05-1; Sequence=Displayed; Name=2 ; IsoId=A2AM05-2; Sequence=VSP_052786, VSP_052787; Name=3 ; IsoId=A2AM05-3; Sequence=VSP_052785; Name=4; IsoId=A2AM05-4; Sequence=VSP_032866; Phosphorylated directly or indirectly by NEK2. Sequence=AAH24869.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC26307.1; Type=Erroneous initiation; Evidence=; nucleoplasm cytoplasm centrosome centriole cytosol cytoskeleton centriole-centriole cohesion protein kinase binding protein domain specific binding protein binding, bridging protein localization to organelle uc008tlk.1 uc008tlk.2 uc008tlk.3 uc008tlk.4 uc008tlk.5 
ENSMUST00000102821.4 Stk10 ENSMUST00000102821.4 serine/threonine kinase 10, transcript variant 1 (from RefSeq NM_009288.2) B1ATW8 ENSMUST00000102821.1 ENSMUST00000102821.2 ENSMUST00000102821.3 Lok NM_009288 O55098 STK10_MOUSE uc007ijt.1 uc007ijt.2 uc007ijt.3 This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Mice deficient for this gene product are viable, but exhibit altered integrin-mediated lymphocyte adhesion characteristics. The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. [provided by RefSeq, Jul 2008]. Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Inhibited by the pyrrole-indolinone inhibitor SU11274 (K00593): intercalates between the ATP-binding Lys-65 and alpha-C glutamate (Glu-81), resulting in a partial disordering of the lysine side chain. Also specifically inhibited by erlotinib. Slightly inhibited by gefitinib (By similarity). Homodimer; homodimerization is required for activation segment autophosphorylation. Cell membrane ; Peripheral membrane protein Expressed predominantly in lymphoid organs such as spleen, thymus, and bone marrow. Autophosphorylates following homodimerization, leading to activation of the protein. Mice do not show any obvious abnormalities. Lymphocytes develop normally but activated lymphocytes show enhanced cell adhesion. Decreased phosphorylation of ERM proteins. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm plasma membrane protein phosphorylation cell cycle membrane kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation activation of protein kinase activity identical protein binding protein homodimerization activity protein autophosphorylation lymphocyte aggregation regulation of lymphocyte migration uc007ijt.1 uc007ijt.2 uc007ijt.3 
ENSMUST00000102823.10 Ttc39b ENSMUST00000102823.10 tetratricopeptide repeat domain 39B (from RefSeq NM_027238.2) B2RX73 ENSMUST00000102823.1 ENSMUST00000102823.2 ENSMUST00000102823.3 ENSMUST00000102823.4 ENSMUST00000102823.5 ENSMUST00000102823.6 ENSMUST00000102823.7 ENSMUST00000102823.8 ENSMUST00000102823.9 NM_027238 Q3V168 Q8BX40 Q8BYY4 Q9D8N8 T39 TT39B_MOUSE Ttc39b uc008tkq.1 uc008tkq.2 uc008tkq.3 Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BYY4-1; Sequence=Displayed; Name=2; IsoId=Q8BYY4-2; Sequence=VSP_026361, VSP_026362; Name=3; IsoId=Q8BYY4-3; Sequence=VSP_026359, VSP_026360; High expression in lung and spleen. Low lower expression in liver and small intestine. Weak expression in heart, brain, kidney, adipose, and adrenal gland. Chow-fed deficient mice display increased HDL- cholesterol level, accompanied by increased ABCA1 and MYLIP expression, increased oxysterols receptors LXR (NR1H3 and NR1H2) protein level without change in NR1H2/3 mRNA levels. Many NR1H2/3 targets are up- regulated, including ABCG5/8, SCD1, ELOVL5, INSIG2 and LPCAT3. Deficiency of TTC39B reduced processing of SREBP1 a pivotal regulator of lipogenesis. When fed with a high-fat/high-cholesterol/bile-salt diet during 20 weeks, used as a model of steatohepatitis resembling human non-alcoholic steatohepatitis, mice show increased HDL cholesterol and APOA1 levels, reduced VLDL (very low density lipoprotein), and reduced mortality compared with wild-type. The livers of deficient mice shown diminished hepatic triglyceride and cholesteryl ester accumulation, fewer inflammatory foci consisting of neutrophils and lymphocytes, less hepatocellular ballooning degeneration and less hepatocyte proliferation compared to control. Knockout mice lacking both TTC39B and LDLR, fed a Western diet for 20 weeks, exhibit a reduction in LDL-cholesterol, but plasma triglyceride levels are not different. Atherosclerotic lesion area of the aorta are reduced compared to LDLR single knockout mice. Belongs to the TTC39 family. molecular_function cellular_component lipid metabolic process regulation of cholesterol efflux negative regulation of cholesterol storage cholesterol homeostasis regulation of cholesterol metabolic process uc008tkq.1 uc008tkq.2 uc008tkq.3 
ENSMUST00000102824.4 Ifit1 ENSMUST00000102824.4 interferon-induced protein with tetratricopeptide repeats 1 (from RefSeq NM_008331.3) ENSMUST00000102824.1 ENSMUST00000102824.2 ENSMUST00000102824.3 Garg16 IFIT1_MOUSE Ifi56 Isg56 NM_008331 Q64282 Q99L77 uc008hgt.1 uc008hgt.2 uc008hgt.3 Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non- sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT2 and IFIT3 (By similarity). Interacts with EIF3E (By similarity). Interacts (via TPR repeats 1-4) with RPL15 (By similarity). Interacts with STING1/MITA and disrupts its interaction with MAVS or TBK1 (By similarity). Interacts with EIF3C. Interacts (via TPR repeats 4-7) with EEF1A1. Cytoplasm By type I interferons, dsRNAs and viruses. RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft. Phosphorylated. ISGylated. Belongs to the IFIT family. immune system process RNA binding protein binding cytoplasm cytosol response to virus response to bacterium cellular response to interferon-alpha cellular response to interferon-beta innate immune response defense response to virus uc008hgt.1 uc008hgt.2 uc008hgt.3 
ENSMUST00000102825.4 Ifit3 ENSMUST00000102825.4 interferon-induced protein with tetratricopeptide repeats 3 (from RefSeq NM_010501.2) ENSMUST00000102825.1 ENSMUST00000102825.2 ENSMUST00000102825.3 Garg49 IFIT3_MOUSE Ifi49 Isg49 NM_010501 Q64345 Q99L62 uc008hgo.1 uc008hgo.2 uc008hgo.3 IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2 (By similarity). Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3 (By similarity). Interacts with IFIT1 and IFIT2 (By similarity). Interacts (via N-terminus) with MAVS, TBK1, TRAF6 and RIGI (By similarity). Interacts with COPS5 (By similarity). Cytoplasm Mitochondrion Induced by T.gondii infection in the testes and uterus. Belongs to the IFIT family. immune system process protein binding cytoplasm mitochondrion cytosol negative regulation of cell proliferation response to virus response to bacterium cellular response to interferon-alpha cellular response to interferon-beta response to stilbenoid identical protein binding negative regulation of apoptotic process innate immune response defense response to virus uc008hgo.1 uc008hgo.2 uc008hgo.3 
ENSMUST00000102826.4 Ifit2 ENSMUST00000102826.4 interferon-induced protein with tetratricopeptide repeats 2, transcript variant 1 (from RefSeq NM_008332.3) ENSMUST00000102826.1 ENSMUST00000102826.2 ENSMUST00000102826.3 Ifit2 NM_008332 Q6GTM0 Q6GTM0_MOUSE uc008hgn.1 uc008hgn.2 uc008hgn.3 uc008hgn.4 Belongs to the IFIT family. cytoplasm endoplasmic reticulum response to virus negative regulation of protein binding cellular response to interferon-alpha positive regulation of apoptotic process uc008hgn.1 uc008hgn.2 uc008hgn.3 uc008hgn.4 
ENSMUST00000102827.4 Icos ENSMUST00000102827.4 inducible T cell co-stimulator (from RefSeq NM_017480.2) Ailim ENSMUST00000102827.1 ENSMUST00000102827.2 ENSMUST00000102827.3 ICOS_MOUSE NM_017480 Q9JL17 Q9WVS0 uc011wlz.1 uc011wlz.2 uc011wlz.3 uc011wlz.4 uc011wlz.5 Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching of immunoglobin isotypes (By similarity). Homodimer; disulfide-linked. Q9WVS0; P26450: Pik3r1; NbExp=2; IntAct=EBI-16721736, EBI-641764; Membrane ; Single-pass type I membrane protein Expressed on activated T-cells and resting memory T-cells. High expression seen in the thymic medulla and in the germinal centers and T-cell zones of lymph nodes and Peyer patches. Expressed at low levels in the spleen. N-glycosylated. T cell tolerance induction protein binding integral component of plasma membrane external side of plasma membrane membrane integral component of membrane T cell costimulation cell-cell adhesion uc011wlz.1 uc011wlz.2 uc011wlz.3 uc011wlz.4 uc011wlz.5 
ENSMUST00000102829.4 4930524B15Rik ENSMUST00000102829.4 RIKEN cDNA 4930524B15 gene, transcript variant 1 (from RefSeq NM_026262.2) CE047_MOUSE ENSMUST00000102829.1 ENSMUST00000102829.2 ENSMUST00000102829.3 NM_026262 Q24JP4 Q8CER9 Q9CQS0 uc007iiu.1 uc007iiu.2 uc007iiu.3 molecular_function cellular_component biological_process uc007iiu.1 uc007iiu.2 uc007iiu.3 
ENSMUST00000102832.3 Cd3e ENSMUST00000102832.3 CD3 antigen, epsilon polypeptide (from RefSeq NM_007648.5) CD3E_MOUSE ENSMUST00000102832.1 ENSMUST00000102832.2 NM_007648 P22646 uc009pez.1 uc009pez.2 uc009pez.3 Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development (PubMed:19956738, PubMed:24899501). Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region. The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with CD6. Interacts with NCK1 (PubMed:24470497). Cell membrane ; Single-pass type I membrane protein Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. Absence of CD3E leads to the complete absence of mature T-cells. Thymocyte development is arrested at the early double- negative (DN) stage. immunological synapse positive regulation of cell-matrix adhesion adaptive immune response immune system process positive regulation of T cell anergy transmembrane signaling receptor activity protein binding plasma membrane cell-cell junction cell surface receptor signaling pathway response to nutrient external side of plasma membrane positive regulation of gene expression negative regulation of gene expression membrane integral component of membrane dendrite development SH3 domain binding cerebellum development T cell differentiation T cell costimulation positive regulation of interferon-gamma production positive regulation of interleukin-4 production T cell differentiation in thymus positive regulation of cell-cell adhesion mediated by integrin T cell receptor complex positive regulation of T cell proliferation alpha-beta T cell receptor complex protein homodimerization activity dendritic spine cell body positive thymic T cell selection negative thymic T cell selection positive regulation of interleukin-2 biosynthetic process negative regulation of smoothened signaling pathway positive regulation of alpha-beta T cell proliferation lymphocyte activation protein heterodimerization activity positive regulation of peptidyl-tyrosine phosphorylation positive regulation of calcium-mediated signaling T cell receptor signaling pathway positive regulation of T cell activation protein homooligomerization apoptotic signaling pathway uc009pez.1 uc009pez.2 uc009pez.3 
ENSMUST00000102840.5 Ass1 ENSMUST00000102840.5 argininosuccinate synthetase 1 (from RefSeq NM_007494.3) Ass1 ENSMUST00000102840.1 ENSMUST00000102840.2 ENSMUST00000102840.3 ENSMUST00000102840.4 NM_007494 Q3UJ34 Q3UJ34_MOUSE uc008jdu.1 uc008jdu.2 uc008jdu.3 Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. Nitrogen metabolism; urea cycle; (N(omega)-L- arginino)succinate from L-aspartate and L-citrulline: step 1/1. urea cycle citrulline metabolic process argininosuccinate metabolic process kidney development liver development argininosuccinate synthase activity ATP binding nucleus cytoplasm mitochondrial outer membrane lysosome endoplasmic reticulum cytosol arginine biosynthetic process aspartate metabolic process acute-phase response midgut development aging response to nutrient circadian rhythm response to toxic substance response to zinc ion response to mycotoxin response to amine toxic substance binding amino acid binding response to estradiol response to lipopolysaccharide response to drug identical protein binding neuron projection neuronal cell body response to amino acid perikaryon response to peptide hormone positive regulation of nitric oxide biosynthetic process response to steroid hormone response to glucocorticoid response to growth hormone diaphragm development response to fatty acid cell body fiber cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to ammonium ion cellular response to cAMP cellular response to interferon-gamma cellular response to tumor necrosis factor cellular response to glucagon stimulus cellular response to oleic acid cellular response to amine stimulus cellular response to laminar fluid shear stress cellular response to dexamethasone stimulus negative regulation of leukocyte cell-cell adhesion uc008jdu.1 uc008jdu.2 uc008jdu.3 
ENSMUST00000102845.11 Rps27a ENSMUST00000102845.11 ribosomal protein S27A, transcript variant 1 (from RefSeq NM_024277.2) ENSMUST00000102845.1 ENSMUST00000102845.10 ENSMUST00000102845.2 ENSMUST00000102845.3 ENSMUST00000102845.4 ENSMUST00000102845.5 ENSMUST00000102845.6 ENSMUST00000102845.7 ENSMUST00000102845.8 ENSMUST00000102845.9 NM_024277 Q642L7 Q642L7_MOUSE Rps27a uc007ihg.1 uc007ihg.2 uc007ihg.3 Nucleus In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. In the N-terminal section; belongs to the ubiquitin family. structural constituent of ribosome ribosome translation uc007ihg.1 uc007ihg.2 uc007ihg.3 
ENSMUST00000102849.11 Usp20 ENSMUST00000102849.11 ubiquitin specific peptidase 20 (from RefSeq NM_028846.5) ENSMUST00000102849.1 ENSMUST00000102849.10 ENSMUST00000102849.2 ENSMUST00000102849.3 ENSMUST00000102849.4 ENSMUST00000102849.5 ENSMUST00000102849.6 ENSMUST00000102849.7 ENSMUST00000102849.8 ENSMUST00000102849.9 Kiaa1003 NM_028846 Q69ZT5 Q8C6M1 Q8CJ72 UBP20_MOUSE Vdu2 uc008jde.1 uc008jde.2 uc008jde.3 uc008jde.4 Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis. Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination. Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization. Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1. Acts as a positive regulator for NF-kappa-B activation by TNF- alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability. Acts as a regulator of G- protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta- arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability. Within the endoplasmic reticulum, participates with USP33 in the rescue of post- translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with VHL, leading to its ubiquitination and subsequent degradation. Interacts with CCP110. Interacts with DIO2. Interacts with HIF1A. Interacts with ADRB2. Interacts with USP18. Cytoplasm Endoplasmic reticulum Cytoplasm, perinuclear region Cytoplasm, cytoskeleton, microtubule organizing center, centrosome The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue (By similarity). Ubiquitinated via a VHL-dependent pathway for proteasomal degradation. USP20-deletion mice produce decreased type I IFNs and proinflammatory cytokines and exhibit increased susceptibility to lethal viral infection compared with WT mice. Belongs to the peptidase C19 family. USP20/USP33 subfamily. Sequence=BAD32361.1; Type=Erroneous initiation; Evidence=; G-protein coupled receptor binding cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity cytoplasm centrosome microtubule organizing center cytoskeleton proteolysis ubiquitin-dependent protein catabolic process endocytosis peptidase activity cysteine-type peptidase activity zinc ion binding regulation of G-protein coupled receptor protein signaling pathway protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity metal ion binding perinuclear region of cytoplasm protein K63-linked deubiquitination protein K48-linked deubiquitination uc008jde.1 uc008jde.2 uc008jde.3 uc008jde.4 
ENSMUST00000102852.6 Ptges ENSMUST00000102852.6 prostaglandin E synthase (from RefSeq NM_022415.3) ENSMUST00000102852.1 ENSMUST00000102852.2 ENSMUST00000102852.3 ENSMUST00000102852.4 ENSMUST00000102852.5 NM_022415 PTGES_MOUSE Pges Q3T9C5 Q9JM51 uc008jcz.1 uc008jcz.2 Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway (PubMed:10869354, PubMed:11795891). Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:11795891, PubMed:10869354). Plays a key role in inflammation response, fever and pain (PubMed:12835414, PubMed:14566340). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4- dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity). Reaction=prostaglandin H2 = prostaglandin E2; Xref=Rhea:RHEA:12893, ChEBI:CHEBI:57405, ChEBI:CHEBI:606564; EC=5.3.99.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12894; Evidence=; Reaction=2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2; Xref=Rhea:RHEA:53324, ChEBI:CHEBI:85166, ChEBI:CHEBI:137172; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53325; Evidence=; Reaction=prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2; Xref=Rhea:RHEA:64364, ChEBI:CHEBI:82629, ChEBI:CHEBI:152564; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64365; Evidence=; Reaction=1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl- S-glutathione + chloride + H(+); Xref=Rhea:RHEA:51220, ChEBI:CHEBI:15378, ChEBI:CHEBI:17996, ChEBI:CHEBI:34718, ChEBI:CHEBI:57925, ChEBI:CHEBI:133977; EC=2.5.1.18; Evidence=; Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48620, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90632; Evidence=; Name=glutathione; Xref=ChEBI:CHEBI:57925; Evidence=; Activity is increased markedly in macrophages and osteoblasts following pro-inflammatory stimuli. Kinetic parameters: KM=37 uM for prostaglandin H2 ; KM=130 uM for glutathione ; pH dependence: Optimum pH is 8. ; Lipid metabolism; prostaglandin biosynthesis. Homotrimer. Membrane ; Multi- pass membrane protein Cytoplasm, perinuclear region Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment. Induced by pro-inflammatory stimuli and down-regulated by anti-inflammatory glucocorticoid. Deficient mice are viable and fertile and develop normally (PubMed:12835414, PubMed:14566340). However mice display a marked reduction in inflammatory responses and reduced pain sensitivity (PubMed:12835414). PTGES deletion results in a reduction of PGE2 levels in the central nervous system in association with the impaired LPS- induced febrile response (PubMed:14566340). Belongs to the MAPEG family. prostaglandin biosynthetic process acute inflammatory response chronic inflammatory response glutathione transferase activity prostaglandin-D synthase activity nuclear envelope lumen cytoplasm mitochondrion lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process glutathione metabolic process negative regulation of cell proliferation response to organic cyclic compound membrane integral component of membrane isomerase activity response to lipopolysaccharide response to retinoic acid response to cytokine intracellular membrane-bounded organelle glutathione binding perinuclear region of cytoplasm prostaglandin-E synthase activity response to calcium ion oxidation-reduction process uc008jcz.1 uc008jcz.2 
ENSMUST00000102853.4 Cstad ENSMUST00000102853.4 CSA-conditional, T cell activation-dependent protein (from RefSeq NM_030137.2) Cstad ENSMUST00000102853.1 ENSMUST00000102853.2 ENSMUST00000102853.3 NM_030137 Q9D245 Q9D245_MOUSE uc008jcp.1 uc008jcp.2 uc008jcp.3 molecular_function mitochondrion mitochondrial outer membrane mitochondrial membrane organization uc008jcp.1 uc008jcp.2 uc008jcp.3 
ENSMUST00000102855.8 Crat ENSMUST00000102855.8 Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta- oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates. (from UniProt P47934) AK132179 CACP_MOUSE Crat ENSMUST00000102855.1 ENSMUST00000102855.2 ENSMUST00000102855.3 ENSMUST00000102855.4 ENSMUST00000102855.5 ENSMUST00000102855.6 ENSMUST00000102855.7 P47934 Q3TCG3 Q3V1Y3 Q923A6 uc289utb.1 uc289utb.2 Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta- oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates. Reaction=(R)-carnitine + acetyl-CoA = CoA + O-acetyl-(R)-carnitine; Xref=Rhea:RHEA:21136, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57589; EC=2.3.1.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21137; Evidence=; Reaction=(R)-carnitine + propanoyl-CoA = CoA + O-propanoyl-(R)- carnitine; Xref=Rhea:RHEA:44976, ChEBI:CHEBI:16347, ChEBI:CHEBI:53210, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44977; Evidence=; Reaction=(R)-carnitine + butanoyl-CoA = CoA + O-butanoyl-(R)-carnitine; Xref=Rhea:RHEA:44980, ChEBI:CHEBI:16347, ChEBI:CHEBI:21949, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44981; Evidence=; Reaction=(R)-carnitine + hexanoyl-CoA = CoA + O-hexanoyl-(R)-carnitine; Xref=Rhea:RHEA:44972, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:62620, ChEBI:CHEBI:84834; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44973; Evidence=; Reaction=(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine; Xref=Rhea:RHEA:17177, ChEBI:CHEBI:16347, ChEBI:CHEBI:18102, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386; EC=2.3.1.137; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17178; Evidence=; Reaction=(R)-carnitine + decanoyl-CoA = CoA + O-decanoyl-(R)-carnitine; Xref=Rhea:RHEA:44828, ChEBI:CHEBI:16347, ChEBI:CHEBI:28717, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44829; Evidence=; Reaction=(R)-carnitine + 3-methylbutanoyl-CoA = CoA + O-3- methylbutanoyl-(R)-carnitine; Xref=Rhea:RHEA:44984, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57345, ChEBI:CHEBI:70819; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44985; Evidence=; Reaction=(R)-carnitine + 2-methylpropanoyl-CoA = CoA + O-isobutanoyl- (R)-carnitine; Xref=Rhea:RHEA:44988, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57338, ChEBI:CHEBI:84838; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44989; Evidence=; Reaction=(R)-carnitine + 2-methylbutanoyl-CoA = CoA + O-2- methylbutanoyl-(R)-carnitine; Xref=Rhea:RHEA:44992, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57336, ChEBI:CHEBI:84840; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44993; Evidence=; Reaction=(R)-carnitine + acetoacetyl-CoA = CoA + O-3-oxobutanoyl-(R)- carnitine; Xref=Rhea:RHEA:44996, ChEBI:CHEBI:16347, ChEBI:CHEBI:57286, ChEBI:CHEBI:57287, ChEBI:CHEBI:84841; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44997; Evidence=; Reaction=(R)-carnitine + 3-hydroxybutanoyl-CoA = CoA + O-3- hydroxybutanoyl-(R)-carnitine; Xref=Rhea:RHEA:45000, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:78611, ChEBI:CHEBI:84842; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45001; Evidence=; Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8- dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061, ChEBI:CHEBI:84654; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44861; Evidence=; Reaction=(R)-carnitine + 2,6-dimethylheptanoyl-CoA = CoA + O-2,6- dimethylheptanoyl-(R)-carnitine; Xref=Rhea:RHEA:45004, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:84843, ChEBI:CHEBI:84847; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45005; Evidence=; Monomer. Endoplasmic reticulum Peroxisome Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the carnitine/choline acetyltransferase family. carnitine O-acetyltransferase activity mitochondrion mitochondrial inner membrane peroxisome endoplasmic reticulum lipid metabolic process fatty acid metabolic process membrane transferase activity transferase activity, transferring acyl groups carnitine metabolic process, CoA-linked uc289utb.1 uc289utb.2 
ENSMUST00000102862.4 Tex48 ENSMUST00000102862.4 testis expressed 48, transcript variant 1 (from RefSeq NM_029324.3) 1700018C11Rik ENSMUST00000102862.1 ENSMUST00000102862.2 ENSMUST00000102862.3 NM_029324 Q9DA81 Q9DA81_MOUSE Tex48 uc008tha.1 uc008tha.2 uc008tha.3 molecular_function cellular_component biological_process uc008tha.1 uc008tha.2 uc008tha.3 
ENSMUST00000102864.5 Rel ENSMUST00000102864.5 reticuloendotheliosis oncogene (from RefSeq NM_009044.3) A4QPD3 A4QPD3_MOUSE ENSMUST00000102864.1 ENSMUST00000102864.2 ENSMUST00000102864.3 ENSMUST00000102864.4 NM_009044 Rel uc007ifo.1 uc007ifo.2 uc007ifo.3 RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex cytoplasm regulation of transcription, DNA-templated I-kappaB kinase/NF-kappaB signaling negative regulation of gene expression negative regulation of interferon-beta production positive regulation of I-kappaB kinase/NF-kappaB signaling sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of neuron death uc007ifo.1 uc007ifo.2 uc007ifo.3 
ENSMUST00000102865.11 Zdhhc12 ENSMUST00000102865.11 zinc finger, DHHC domain containing 12, transcript variant 2 (from RefSeq NM_001037762.1) ENSMUST00000102865.1 ENSMUST00000102865.10 ENSMUST00000102865.2 ENSMUST00000102865.3 ENSMUST00000102865.4 ENSMUST00000102865.5 ENSMUST00000102865.6 ENSMUST00000102865.7 ENSMUST00000102865.8 ENSMUST00000102865.9 NM_001037762 Q8VC90 Q9CZ24 Q9D0T6 ZDH12_MOUSE Zdhhc12 uc008jbe.1 uc008jbe.2 uc008jbe.3 Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:25025157). Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering (PubMed:25025157). Thereby, indirectly regulates GABAergic synaptic transmission (PubMed:25025157). Acts as an inhibitor of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, thereby promoting NLRP3 degradation by the chaperone-mediated autophagy (CMA) process (PubMed:36586411). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Golgi apparatus membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VC90-1; Sequence=Displayed; Name=2; IsoId=Q8VC90-2; Sequence=VSP_006946; The DHHC domain is required for palmitoyltransferase activity. Mice display enhanced inflammatory symptoms and lethality following alum-induced peritonitis and LPS-induced endotoxic shock; defects are caused by an increased NLRP3 inflammasome activation. Belongs to the DHHC palmitoyltransferase family. Sequence=AK013074; Type=Frameshift; Evidence=; endoplasmic reticulum Golgi apparatus protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity uc008jbe.1 uc008jbe.2 uc008jbe.3 
ENSMUST00000102869.8 Xpo1 ENSMUST00000102869.8 exportin 1, transcript variant 1 (from RefSeq NM_134014.3) Crm1 ENSMUST00000102869.1 ENSMUST00000102869.2 ENSMUST00000102869.3 ENSMUST00000102869.4 ENSMUST00000102869.5 ENSMUST00000102869.6 ENSMUST00000102869.7 NM_134014 Q6P5F9 XPO1_MOUSE uc287wyx.1 uc287wyx.2 Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity). Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA (PubMed:10786834). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUP42, NUP88, NUP214, RANBP3 and TERT. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at 'Lys-129'. Interacts with SERTAD2; the interaction translocates SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1. Interacts with DCAF8 (By similarity). Interacts with DTNBP1 and the interaction translocates DTNBP1 out of the nucleus (PubMed:20921223). Interacts with CPEB3 (By similarity). Interacts with HAX1 (By similarity). Interacts with BOK; translocates to the cytoplasm (By similarity). Interacts with HSP90AB1 (By similarity). Interacts with LRPPRC; interacts with LRPPRC alone and also when LRPPRC is in complex with EIF4E and with EIF4E sensitivity element (4ESE)-containing mRNAs to form an EIF4E-dependent mRNA export complex (By similarity). Q6P5F9; Q6GNU1: arpc1b-b; Xeno; NbExp=2; IntAct=EBI-2550236, EBI-11607516; Q6P5F9; Q3B8L5: LOC495502; Xeno; NbExp=2; IntAct=EBI-2550236, EBI-11608794; Q6P5F9; Q00987: MDM2; Xeno; NbExp=4; IntAct=EBI-2550236, EBI-389668; Q6P5F9; P0DJZ2: NS2; Xeno; NbExp=2; IntAct=EBI-2550236, EBI-9673535; Q6P5F9; P61925: PKIA; Xeno; NbExp=4; IntAct=EBI-2550236, EBI-2682139; Q6P5F9; P62826: RAN; Xeno; NbExp=3; IntAct=EBI-2550236, EBI-286642; Q6P5F9; B7ZR20: septin2.L; Xeno; NbExp=2; IntAct=EBI-2550236, EBI-11608460; Q6P5F9; O95149: SNUPN; Xeno; NbExp=2; IntAct=EBI-2550236, EBI-714033; Q6P5F9; Q91855: SUP35; Xeno; NbExp=2; IntAct=EBI-2550236, EBI-11606693; Cytoplasm Nucleus, nucleoplasm Nucleus, Cajal body Nucleus, nucleolus Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm (By similarity). Belongs to the exportin family. ribosomal subunit export from nucleus ribosomal large subunit export from nucleus ribosomal small subunit export from nucleus negative regulation of transcription from RNA polymerase II promoter kinetochore RNA binding nuclear export signal receptor activity protein binding nucleus annulate lamellae nucleoplasm nucleolus cytoplasm cytosol protein export from nucleus intracellular protein transport nucleocytoplasmic transport Ran GTPase binding regulation of centrosome duplication Cajal body protein transport protein domain specific binding nuclear membrane macromolecular complex protein localization to nucleus regulation of protein catabolic process ribosome biogenesis response to drug intracellular membrane-bounded organelle regulation of protein export from nucleus mRNA transport ribonucleoprotein complex uc287wyx.1 uc287wyx.2 
ENSMUST00000102871.10 L1cam ENSMUST00000102871.10 L1 cell adhesion molecule, transcript variant 1 (from RefSeq NM_008478.3) ENSMUST00000102871.1 ENSMUST00000102871.2 ENSMUST00000102871.3 ENSMUST00000102871.4 ENSMUST00000102871.5 ENSMUST00000102871.6 ENSMUST00000102871.7 ENSMUST00000102871.8 ENSMUST00000102871.9 L1cam NM_008478 Q6PGJ3 Q6PGJ3_MOUSE uc009tmv.1 uc009tmv.2 uc009tmv.3 Membrane ; Single- pass type I membrane protein Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. plasma membrane cell-matrix adhesion axon guidance cell surface membrane integral component of membrane cell migration protein domain specific binding axon neuron projection development neuronal cell body synapse organization axon development uc009tmv.1 uc009tmv.2 uc009tmv.3 
ENSMUST00000102872.11 Rapgef1 ENSMUST00000102872.11 Rap guanine nucleotide exchange factor (GEF) 1, transcript variant 3 (from RefSeq NM_054050.2) ENSMUST00000102872.1 ENSMUST00000102872.10 ENSMUST00000102872.2 ENSMUST00000102872.3 ENSMUST00000102872.4 ENSMUST00000102872.5 ENSMUST00000102872.6 ENSMUST00000102872.7 ENSMUST00000102872.8 ENSMUST00000102872.9 Grf2 NM_054050 Q91ZZ2 Q91ZZ2_MOUSE Rapgef1 uc008izw.1 uc008izw.2 uc008izw.3 Q91ZZ2; Q60631: Grb2; NbExp=3; IntAct=EBI-644719, EBI-1688; blood vessel development SH3/SH2 adaptor activity guanyl-nucleotide exchange factor activity protein binding cytoplasm early endosome small GTPase mediated signal transduction positive regulation of neuron projection development Rap guanyl-nucleotide exchange factor activity phagocytic vesicle membrane Rap protein signal transduction macromolecular complex nerve growth factor signaling pathway positive regulation of GTPase activity regulation of JNK cascade negative regulation of Ras protein signal transduction platelet-derived growth factor receptor signaling pathway perinuclear region of cytoplasm negative regulation of protein kinase B signaling establishment of endothelial barrier negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to cAMP negative regulation of canonical Wnt signaling pathway activation of GTPase activity cell-cell adhesion regulation of cell junction assembly positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis cellular response to nerve growth factor stimulus negative regulation of neural precursor cell proliferation uc008izw.1 uc008izw.2 uc008izw.3 
ENSMUST00000102873.8 Ntng2 ENSMUST00000102873.8 netrin G2, transcript variant a (from RefSeq NM_133500.2) A2AKX0 ENSMUST00000102873.1 ENSMUST00000102873.2 ENSMUST00000102873.3 ENSMUST00000102873.4 ENSMUST00000102873.5 ENSMUST00000102873.6 ENSMUST00000102873.7 Lmnt2 NM_133500 NTNG2_MOUSE Q8R4F1 Q8R4F2 Q8VIP6 Q8VIP7 Q8VIP8 uc008izp.1 uc008izp.2 uc008izp.3 uc008izp.4 The protein encoded by this gene belongs to a subclass of the netrin family called netrin-G proteins. Unlike classic netrins, which act as diffusible chemoattractants, netrin-Gs are glycosylphosphatidylinositol-anchored membrane proteins that interact with specific transmembrane proteins. In mouse, this gene is preferentially expressed in the cerebral cortex, habenular nucleus and superior colliculus. Knockout mutant mice display a lack of behavioral startle in response to acoustic stimuli. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. Interacts with LRRC4. Cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side Event=Alternative splicing; Named isoforms=3; Name=2B ; Synonyms=G2b ; IsoId=Q8R4F1-1; Sequence=Displayed; Name=2A ; Synonyms=G2a ; IsoId=Q8R4F1-2; Sequence=VSP_050562, VSP_050563; Name=2C ; Synonyms=G2c ; IsoId=Q8R4F1-3; Sequence=VSP_050564, VSP_050565; Expression is restricted primarily to neurons of the CNS, particularly in the cerebral cortex, habenular nucleus and superior colliculus. Low levels in lung, kidney, heart and spleen. Expression is detected from embryonic day 9. Strong expression is maintained from embryonic day 14 well into adulthood. The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4/NGL2 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains (By similarity). N-glycosylated. molecular_function protein binding cytosol plasma membrane multicellular organism development nervous system development axonogenesis animal organ morphogenesis tissue development membrane cell differentiation axon anchored component of membrane intercellular bridge anchored component of plasma membrane modulation of synaptic transmission Flemming body glutamatergic synapse anchored component of presynaptic active zone membrane synaptic membrane adhesion regulation of presynapse assembly uc008izp.1 uc008izp.2 uc008izp.3 uc008izp.4 
ENSMUST00000102874.11 Mdh1 ENSMUST00000102874.11 Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2- oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS). (from UniProt P14152) AK005237 ENSMUST00000102874.1 ENSMUST00000102874.10 ENSMUST00000102874.2 ENSMUST00000102874.3 ENSMUST00000102874.4 ENSMUST00000102874.5 ENSMUST00000102874.6 ENSMUST00000102874.7 ENSMUST00000102874.8 ENSMUST00000102874.9 MDHC_MOUSE Mor2 P14152 Q3TP22 Q80Y13 Q9DB45 uc007idv.1 uc007idv.2 uc007idv.3 uc007idv.4 Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2- oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS). Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate; Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21433; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21434; Evidence=; Reaction=(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4- hydroxyphenyl)pyruvate + H(+) + NADH; Xref=Rhea:RHEA:10780, ChEBI:CHEBI:10980, ChEBI:CHEBI:15378, ChEBI:CHEBI:36242, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.96; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:10782; Evidence=; Reaction=(S)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH; Xref=Rhea:RHEA:57172, ChEBI:CHEBI:15378, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:57174; Evidence=; Homodimer. Cytoplasm, cytosol ISGylated. Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation. Belongs to the LDH/MDH superfamily. MDH type 2 family. catalytic activity cytoplasm mitochondrion cytosol carbohydrate metabolic process tricarboxylic acid cycle oxaloacetate metabolic process malate metabolic process NADH metabolic process oxidoreductase activity malate dehydrogenase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor NAD metabolic process carboxylic acid metabolic process L-malate dehydrogenase activity myelin sheath NAD binding oxidation-reduction process uc007idv.1 uc007idv.2 uc007idv.3 uc007idv.4 
ENSMUST00000102875.11 Ugp2 ENSMUST00000102875.11 UDP-glucose pyrophosphorylase 2, transcript variant 1 (from RefSeq NM_139297.6) ENSMUST00000102875.1 ENSMUST00000102875.10 ENSMUST00000102875.2 ENSMUST00000102875.3 ENSMUST00000102875.4 ENSMUST00000102875.5 ENSMUST00000102875.6 ENSMUST00000102875.7 ENSMUST00000102875.8 ENSMUST00000102875.9 NM_139297 Q8R3D2 Q91ZJ5 UGPA_MOUSE uc007ids.1 uc007ids.2 uc007ids.3 uc007ids.4 uc007ids.5 uc007ids.6 UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP- alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885; EC=2.7.7.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19890; Evidence=; Glycan biosynthesis; glycogen biosynthesis. Homooctamer. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91ZJ5-1; Sequence=Displayed; Name=2; IsoId=Q91ZJ5-2; Sequence=VSP_012835; Belongs to the UDPGP type 1 family. UTP:glucose-1-phosphate uridylyltransferase activity glucose binding cytoplasm glycogen metabolic process UDP-glucose metabolic process transferase activity nucleotidyltransferase activity glucose 1-phosphate metabolic process pyrimidine ribonucleotide binding identical protein binding metal ion binding uridylyltransferase activity uc007ids.1 uc007ids.2 uc007ids.3 uc007ids.4 uc007ids.5 uc007ids.6 
ENSMUST00000102880.5 Ppp3r1 ENSMUST00000102880.5 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) (from RefSeq NM_024459.2) CANB1_MOUSE Cnb ENSMUST00000102880.1 ENSMUST00000102880.2 ENSMUST00000102880.3 ENSMUST00000102880.4 NM_024459 Q3V067 Q5F225 Q63810 uc007ica.1 uc007ica.2 uc007ica.3 Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B) (PubMed:26794871). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). The regulatory subunit confers calcium sensitivity. Interacts with catalytic subunit PPP3CA/calcineurin A (PubMed:26794871). Interacts with catalytic subunit PPP3CB/calcineurin A (By similarity). Isoform 1 and isoform 2 interact with CIB1 (via C-terminal region); the interaction increases upon cardiomyocyte hypertrophy (PubMed:20639889). Interacts with SPATA33 (via PQIIIT motif) (By similarity). Q63810; O35099: Map3k5; NbExp=3; IntAct=EBI-6666164, EBI-777493; Cytoplasm, cytosol Cell membrane Cell membrane, sarcolemma Cell membrane ; Lipid-anchor Note=Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q63810-1; Sequence=Displayed; Name=2; IsoId=Q63810-2; Sequence=VSP_024842; Expressed in osteoblasts and bone marrow (at protein level) (PubMed:16286645). Expressed in the brain, kidney, liver, lung, muscle, ovary, spleen, thymus, heart and testis (PubMed:1325794). This protein has four functional calcium-binding sites. Belongs to the calcineurin regulatory subunit family. branching involved in blood vessel morphogenesis epithelial to mesenchymal transition phosphoprotein phosphatase activity calcium ion binding protein binding cytoplasm cytosol plasma membrane calcineurin complex protein dephosphorylation protein import into nucleus heart development Schwann cell development cyclosporin A binding membrane enzyme binding phosphatase binding protein domain specific binding myelination in peripheral nervous system calcineurin-NFAT signaling cascade protein localization to nucleus sarcolemma synapse positive regulation of transcription from RNA polymerase II promoter metal ion binding lung epithelial cell differentiation postsynapse glutamatergic synapse uc007ica.1 uc007ica.2 uc007ica.3 
ENSMUST00000102881.10 Plek ENSMUST00000102881.10 pleckstrin (from RefSeq NM_019549.2) ENSMUST00000102881.1 ENSMUST00000102881.2 ENSMUST00000102881.3 ENSMUST00000102881.4 ENSMUST00000102881.5 ENSMUST00000102881.6 ENSMUST00000102881.7 ENSMUST00000102881.8 ENSMUST00000102881.9 NM_019549 PLEK_MOUSE Q9ERI9 Q9JHK5 uc007ibv.1 uc007ibv.2 uc007ibv.3 uc007ibv.4 Major protein kinase C substrate of platelets. hematopoietic progenitor cell differentiation platelet degranulation protein kinase C binding cytoplasm plasma membrane vesicle docking involved in exocytosis integrin-mediated signaling pathway positive regulation of platelet activation negative regulation of inositol phosphate biosynthetic process positive regulation of inositol-polyphosphate 5-phosphatase activity cell projection organization positive regulation of actin filament depolymerization phospholipase C-inhibiting G-protein coupled receptor signaling pathway cortical actin cytoskeleton organization ruffle organization actin cytoskeleton reorganization positive regulation of actin filament bundle assembly ruffle membrane positive regulation of integrin activation intracellular signal transduction protein homodimerization activity phosphatidylinositol-3,4-bisphosphate binding negative regulation of G-protein coupled receptor protein signaling pathway phosphatidylinositol metabolic process regulation of cell diameter thrombin-activated receptor signaling pathway platelet aggregation protein kinase C signaling protein secretion by platelet uc007ibv.1 uc007ibv.2 uc007ibv.3 uc007ibv.4 
ENSMUST00000102886.10 Sardh ENSMUST00000102886.10 sarcosine dehydrogenase (from RefSeq NM_138665.2) ENSMUST00000102886.1 ENSMUST00000102886.2 ENSMUST00000102886.3 ENSMUST00000102886.4 ENSMUST00000102886.5 ENSMUST00000102886.6 ENSMUST00000102886.7 ENSMUST00000102886.8 ENSMUST00000102886.9 NM_138665 Q99LB7 SARDH_MOUSE Sardh uc008ixg.1 uc008ixg.2 uc008ixg.3 uc008ixg.4 Catalyzes the last step of the oxidative degradation of choline to glycine. Converts sarcosine into glycine. Reaction=(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine = (6R)-5,10- methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:19793, Rhea:RHEA- COMP:10685, Rhea:RHEA-COMP:10686, Rhea:RHEA-COMP:13257, Rhea:RHEA- COMP:14738, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305, ChEBI:CHEBI:57433, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:136572, ChEBI:CHEBI:141005; EC=1.5.8.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19794; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD covalently per monomer. ; Amine and polyamine degradation; sarcosine degradation; formaldehyde and glycine from sarcosine: step 1/1. Mitochondrion matrix Belongs to the GcvT family. folic acid binding cytoplasm mitochondrion mitochondrial matrix sarcosine dehydrogenase activity oxidoreductase activity tetrahydrofolate interconversion flavin adenine dinucleotide binding oxidation-reduction process sarcosine catabolic process uc008ixg.1 uc008ixg.2 uc008ixg.3 uc008ixg.4 
ENSMUST00000102888.10 Camk2a ENSMUST00000102888.10 calcium/calmodulin-dependent protein kinase II alpha, transcript variant 2 (from RefSeq NM_177407.4) ENSMUST00000102888.1 ENSMUST00000102888.2 ENSMUST00000102888.3 ENSMUST00000102888.4 ENSMUST00000102888.5 ENSMUST00000102888.6 ENSMUST00000102888.7 ENSMUST00000102888.8 ENSMUST00000102888.9 KCC2A_MOUSE NM_177407 P11798 Q61284 Q6ZWN4 uc008fbg.1 uc008fbg.2 uc008fbg.3 uc008fbg.4 Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (By similarity). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (By similarity). Also regulates the migration of developing neurons (By similarity). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (PubMed:15994560). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK- STAT signaling pathway (By similarity). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2- AG)-mediated synaptic signaling via modulation of DAGLA activity (PubMed:23502535). [Isoform Alpha KAP]: Has no kinase activity. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-286 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity. There are 4 genes encoding calcium/calmodulin-dependent protein kinase type II chains: CAMK2A, CAMK2B, CAMK2G and CAMK2D. The corresponding proteins assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (By similarity). Interacts with BAALC. Interacts with MPDZ. Interacts with SYN1. Interacts with CAMK2N2. Interacts with SYNGAP1. Interacts with SYNPO2 (By similarity). Interacts with SHANK3. Interacts with GRIN2B. Interacts with CACNB2. Interacts with LRRC7. Interacts with GRM5 (By similarity). Interacts with DAGLA (via C-terminal); this interaction is enhanced by autophosphorylation of CAMK2A at Thr-286 (PubMed:23502535). Interacts with CAMK2N1; this interaction requires CAMK2A activation by Ca(2+) (By similarity). P11798; Q9JI91: Actn2; NbExp=3; IntAct=EBI-400384, EBI-299169; P11798; Q62108: Dlg4; NbExp=4; IntAct=EBI-400384, EBI-300895; P11798; Q01097: Grin2b; NbExp=5; IntAct=EBI-400384, EBI-400125; P11798; Q00960: Grin2b; Xeno; NbExp=4; IntAct=EBI-400384, EBI-396905; P11798; P70587: Lrrc7; Xeno; NbExp=2; IntAct=EBI-400384, EBI-7798464; P11798-2; Q9Z1R2: Bag6; NbExp=3; IntAct=EBI-400402, EBI-644645; [Isoform Alpha KAP]: Cytoplasm Synapse Postsynaptic density Cell projection, dendritic spine Cell projection, dendrite Note=Postsynaptic lipid rafts. Event=Alternative splicing; Named isoforms=2; Name=Alpha CaMKII; IsoId=P11798-1; Sequence=Displayed; Name=Alpha KAP ; IsoId=P11798-2; Sequence=VSP_004767, VSP_004768, VSP_004769; [Isoform Alpha CaMKII]: Expressed in brain. [Isoform Alpha KAP]: Expressed in skeletal muscle. Autophosphorylation of Thr-286 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state. Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. G1/S transition of mitotic cell cycle nucleotide binding response to ischemia protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity protein binding calmodulin binding ATP binding nucleus cytoplasm mitochondrion cytosol plasma membrane calcium- and calmodulin-dependent protein kinase complex protein phosphorylation calcium ion transport calcium-dependent protein serine/threonine kinase activity positive regulation of cardiac muscle cell apoptotic process postsynaptic density membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation cell junction axon dendrite GTPase activating protein binding dendrite cytoplasm ionotropic glutamate receptor signaling pathway glutamate receptor binding angiotensin-activated signaling pathway identical protein binding protein homodimerization activity cell projection neuron projection neuronal cell body dendritic spine synapse postsynaptic membrane protein autophosphorylation metal ion binding regulation of neurotransmitter secretion regulation of neuronal synaptic plasticity dendrite morphogenesis positive regulation of NF-kappaB transcription factor activity positive regulation of calcium ion transport dendritic spine development postsynaptic neurotransmitter receptor diffusion trapping glutamatergic synapse NMDA selective glutamate receptor signaling pathway calmodulin dependent kinase signaling pathway presynaptic cytosol postsynaptic cytosol glutamatergic postsynaptic density postsynaptic specialization membrane regulation of mitochondrial membrane permeability involved in apoptotic process regulation of protein localization to plasma membrane peptidyl-threonine autophosphorylation regulation of neuron migration uc008fbg.1 uc008fbg.2 uc008fbg.3 uc008fbg.4 
ENSMUST00000102889.10 Ecpas ENSMUST00000102889.10 Ecm29 proteasome adaptor and scaffold, transcript variant 2 (from RefSeq NM_172381.3) A2ALW0 ECM29_MOUSE ENSMUST00000102889.1 ENSMUST00000102889.2 ENSMUST00000102889.3 ENSMUST00000102889.4 ENSMUST00000102889.5 ENSMUST00000102889.6 ENSMUST00000102889.7 ENSMUST00000102889.8 ENSMUST00000102889.9 Ecm29 Ecpas Kiaa0368 NM_172381 Q6PDI5 Q6ZQC9 Q8BSW7 Q8CAH0 Q8R3M6 uc008sze.1 uc008sze.2 uc008sze.3 uc008sze.4 Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (By similarity). Promotes proteasome dissociation under oxidative stress (PubMed:26802743). Non-stoichiometric component of the proteasome; associates with the 26S proteasome. Interacts (via N-terminus) with VPS11, VPS26A, VPS36, RAB11FIP4 and RABEP1. Interacts (via C-terminus) with DCTN1, DCTN2, KIF5B, MYH7, MYH10, MYO10 and ARF6. Endoplasmic reticulum Endoplasmic reticulum-Golgi intermediate compartment Endosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Endosome, multivesicular body Cytoplasmic vesicle Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=Q6PDI5-2; Sequence=Displayed; Name=1; IsoId=Q6PDI5-1; Sequence=VSP_062174; Name=3; IsoId=Q6PDI5-3; Sequence=VSP_062175, VSP_062176; Widely expressed (at protein level). Deficient mice are viable, fertile, and do not show any histological abnormalities. Under stressed condition, 26S proteasome dissociates in wild-type cells, but not in cells from deficient mice. Belongs to the ECM29 family. Sequence=AAH25035.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; proteasome complex nucleus cytoplasm endosome early endosome late endosome multivesicular body endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment centrosome microtubule organizing center cytoskeleton ER to Golgi transport vesicle endocytic vesicle ER-associated ubiquitin-dependent protein catabolic process cytoplasmic vesicle proteasome assembly binding, bridging proteasome binding uc008sze.1 uc008sze.2 uc008sze.3 uc008sze.4 
ENSMUST00000102891.4 Adamts13 ENSMUST00000102891.4 ADAM metallopeptidase with thrombospondin type 1 motif 13, transcript variant 2 (from RefSeq NM_001290463.1) A2ALB4 ATS13_MOUSE ENSMUST00000102891.1 ENSMUST00000102891.2 ENSMUST00000102891.3 Gm710 NM_001290463 Q769J6 Q76LW1 uc008iwp.1 uc008iwp.2 uc008iwp.3 This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. In certain mouse strains (C57BL/6, for example) an intracisternal A-type particle (IAP) retrotransposon sequence is located in the intron 23 that causes an alternate splicing event resulting in a shorter transcript variants encoding shorter isoforms. The encoded preproprotein undergoes proteolytic processing to generate an active enzyme that cleaves von Willebrand factor (VWF) in circulating blood. [provided by RefSeq, Jul 2016]. Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. Reaction=The enzyme cleaves the von Willebrand factor at bond 842- Tyr-|-Met-843 within the A2 domain.; EC=3.4.24.87; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 4 Ca(2+) ions. ; Zinc and calcium ions cooperatively modulate enzyme activity. The cleavage of the pro-domain is not required for protease activity. Dependence on calcium for proteolytic activity is mediated by the high affinity site (By similarity). Secreted Note=Secretion enhanced by O-fucosylation of TSP type-1 repeats. Plasma. Expression is consistently high in liver, medium in lung and spleen, low in skeletal muscle and undetectable in heart, brain, kidney and testis. Increases steadly with the age of embryo, reaching highest levels in embryonic tissues of 19 days of gestation. The pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency. The globular cysteineless spacer domain adopts a jelly-roll topology, and is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction (By similarity). The precursor is processed by a furin endopeptidase which cleaves off the pro-domain. O-glycosylated (By similarity). O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1- X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS13. May also be C-glycosylated on tryptophan residues within the consensus sequence W- X-X-W of the TPRs, and also N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). Two variants (Adamts13L and Adamts13S) were isolated that differed in the insertion of an intracisternal A particle (IAP) retrotransposon including a premature stop at the position 1036. In Adamts13S the C-terminal two TSP type-1 and two CUB domains are replaced with a 16-amino acid sequence derived from the IAP, this variant exhibited vWF cleaving activities in vitro. The IAP insertion is strain-specific and is found in BALB/c, C3H/He, C57BL/6 and DBA/2 strains, but not in the 129/Sv strain. endopeptidase activity metalloendopeptidase activity extracellular region extracellular space proteolysis blood coagulation hemostasis peptidase activity metallopeptidase activity response to toxic substance response to amine hydrolase activity response to interferon-gamma response to tumor necrosis factor response to potassium ion peptide catabolic process metal ion binding response to interleukin-4 cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-4 cellular response to tumor necrosis factor uc008iwp.1 uc008iwp.2 uc008iwp.3 
ENSMUST00000102893.10 Musk ENSMUST00000102893.10 muscle, skeletal, receptor tyrosine kinase, transcript variant 6 (from RefSeq NM_001165996.1) ENSMUST00000102893.1 ENSMUST00000102893.2 ENSMUST00000102893.3 ENSMUST00000102893.4 ENSMUST00000102893.5 ENSMUST00000102893.6 ENSMUST00000102893.7 ENSMUST00000102893.8 ENSMUST00000102893.9 MUSK_MOUSE NM_001165996 Nsk2 Q61005 Q61006 Q61987 Q61988 uc033ick.1 uc033ick.2 This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Positively regulated by CK2. Monomer. Homodimer (Probable). Interacts with LRP4; the heterodimer forms an AGRIN receptor complex that binds AGRIN resulting in activation of MUSK. Forms a heterotetramer composed of 2 DOK7 and 2 MUSK molecules which facilitates MUSK trans-autophosphorylation on tyrosine residue and activation. Interacts (via cytoplasmic part) with DOK7 (via IRS-type PTB domain); requires MUSK phosphorylation. Interacts with DVL1 (via DEP domain); the interaction is direct and mediates the formation of a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering. Interacts with PDZRN3; this interaction is enhanced by agrin. Interacts with FNTA; the interaction is direct and mediates AGRIN-induced phosphorylation and activation of FNTA. Interacts with CSNK2B; mediates regulation by CK2. Interacts (via the cytoplasmic domain) with DNAJA3. Interacts with NSF; may regulate MUSK endocytosis and activity. Interacts with CAV3; may regulate MUSK signaling. Interacts with RNF31. Q61006; Q18PE0: Dok7; NbExp=3; IntAct=EBI-3989087, EBI-3989091; Q61006-3; P46460: Nsf; NbExp=5; IntAct=EBI-6308424, EBI-398006; Postsynaptic cell membrane ; Single-pass type I membrane protein Note=Localizes to the postsynaptic cell membrane of the neuromuscular junction. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=MLK2; IsoId=Q61006-1; Sequence=Displayed; Name=2; Synonyms=MLK1; IsoId=Q61006-2; Sequence=VSP_010784; Name=3; IsoId=Q61006-3; Sequence=VSP_010785; Name=4; IsoId=Q61006-4; Sequence=VSP_010786; Expressed preferentially in skeletal muscle. Skeletal myogenesis is a major site of expression during normal embryogenesis. In addition, the ganglia of the developing peripheral nervous system and various embryonic epithelia, including those of kidney, lung and gut are also sites of expression. Ubiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation. Phosphorylated (PubMed:16818610). Phosphorylation is induced by AGRIN (PubMed:8653787, PubMed:18848351). Autophosphorylated. Autophosphorylation at Tyr-553 is required for interaction with DOK7 which in turn stimulates the phosphorylation and the activation of MUSK (PubMed:16794080, PubMed:20603078). Neddylated. Mice die perinatally being unable to take a breath and to respond to tail or leg pinch. Despite the presence of apparently normal skeletal muscle, the absence of differentiated nerve terminals is sufficient to account for this phenotype. Every aspect of NMJ formation examined is absent in these mice. Branches of the main intramuscular nerve do not establish normal contacts with the muscle, do not form correctly positioned or specialized nerve terminals, and are apparently not given appropriate signals to stop their wandering aimlessly across the muscle. Furthermore, postsynaptic differentiation is absent, muscle-derived proteins normally localized to the synaptic basal lamina or the postsynaptic membrane being uniformly distributed in myofibers. Belongs to the protein kinase superfamily. Tyr protein kinase family. nucleotide binding positive regulation of protein phosphorylation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein binding ATP binding plasma membrane integral component of plasma membrane regulation of transcription, DNA-templated protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development neuromuscular junction development memory regulation of synaptic growth at neuromuscular junction external side of plasma membrane positive regulation of gene expression negative regulation of gene expression positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation protein kinase binding cell junction cell differentiation PDZ domain binding neuromuscular junction positive regulation of synaptic transmission, cholinergic cell projection receptor clustering receptor complex regulation of MAPK cascade positive regulation of MAPK cascade positive regulation of neuron apoptotic process synapse postsynaptic membrane positive regulation of synaptic growth at neuromuscular junction protein autophosphorylation metal ion binding positive regulation of peptidyl-tyrosine phosphorylation response to electrical stimulus long-term synaptic potentiation skeletal muscle acetylcholine-gated channel clustering positive regulation of skeletal muscle acetylcholine-gated channel clustering positive regulation of protein geranylgeranylation positive regulation of ERK1 and ERK2 cascade uc033ick.1 uc033ick.2 
ENSMUST00000102894.6 Lilrb4b ENSMUST00000102894.6 leukocyte immunoglobulin-like receptor, subfamily B, member 4B, transcript variant 1 (from RefSeq NM_008147.3) ENSMUST00000102894.1 ENSMUST00000102894.2 ENSMUST00000102894.3 ENSMUST00000102894.4 ENSMUST00000102894.5 Gp49 Gp49a LRB4B_MOUSE Lilrb4b NM_008147 Q549E3 Q61450 uc007fao.1 uc007fao.2 uc007fao.3 uc007fao.4 Plays a role in mast cell activation. Monomer and homodimer. Cell membrane ingle-pass type I membrane protein Expressed on mast cells (at protein level) (PubMed:10630292, PubMed:10982834). Also expressed at much lower levels on natural killer cells (at protein level) (PubMed:10982834). In contrast to the related Lilrb4a protein, does not contain any copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). membrane integral component of membrane uc007fao.1 uc007fao.2 uc007fao.3 uc007fao.4 
ENSMUST00000102895.7 Robo4 ENSMUST00000102895.7 roundabout guidance receptor 4, transcript variant 2 (from RefSeq NM_028783.4) ENSMUST00000102895.1 ENSMUST00000102895.2 ENSMUST00000102895.3 ENSMUST00000102895.4 ENSMUST00000102895.5 ENSMUST00000102895.6 NM_028783 Q8C310 Q9DBW1 ROBO4_MOUSE uc009ous.1 uc009ous.2 uc009ous.3 uc009ous.4 Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Involved in the maintenance of endothelial barrier organization and function (By similarity). Interacts with SLIT2 and ENAH. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C310-1; Sequence=Displayed; Name=2; IsoId=Q8C310-2; Sequence=VSP_010662; Name=3; IsoId=Q8C310-3; Sequence=VSP_010663, VSP_010662; Expressed specifically in embryo and adult vascular endothelium. In embryonic development of vascular endothelium, it shows a dynamic expression pattern within vessels, with expression starting in the larger axial vessels and intersomitic vessels at earlier ages, and changing to intersomitic vessel and capillary expression at later stages. At 9.0 dpc, is expressed in the central vessels, the dorsal aorta, and intersomitic vessels. At 9.5 dpc, is highly expressed in intersomitic vessels with little expression remaining in dorsal aortae. By 10.0 dpc, is detected in capillary vessels, the capillary plexus of the limb buds, and throughout the endothelium as microvessels sprout from the dorsal aortae. No expression was detected in the neural tube at 9.0 dpc and 9.5 dpc. However, it is detected within the capillaries sprouting into the neural tube, as well as in the adjacent perineural capillary plexus at 10.0 dpc. At 11.5 dpc, it is expressed in the endocardial layer of the cushions and delamination zones. By 17 dpc, it is detected in both the endothelial and interstitial cells of the developing aortic valve and endothelial cells of the proximal aorta. At 5 weeks after birth, it is localized to the endothelial layer of the ascending aorta and persists throughout postnatal development (PubMed:30455415). Homozygous knockout mice exhibit a complex cardiovascular phenotype that includes a combination of aortic valve thickening with or without bicuspid aortic valve, aortic valve stenosis, regurgitation and/or ascending aortic aneurysm. In general, these phenotypes are observed with low penetrance and male predominance. Belongs to the immunoglobulin superfamily. ROBO family. Sequence=AAH20129.1; Type=Erroneous initiation; Evidence=; Sequence=BAB23506.2; Type=Erroneous initiation; Evidence=; [Isoform 2]: Sequence=AAH20129.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB23506.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; [Isoform 3]: Sequence=BAC39850.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC39850.1; Type=Frameshift; Evidence=; angiogenesis protein binding multicellular organism development external side of plasma membrane integral component of membrane cell differentiation negative regulation of cell migration signaling receptor activity uc009ous.1 uc009ous.2 uc009ous.3 uc009ous.4 
ENSMUST00000102897.11 Txndc8 ENSMUST00000102897.11 thioredoxin domain containing 8, transcript variant 1 (from RefSeq NM_026132.3) ENSMUST00000102897.1 ENSMUST00000102897.10 ENSMUST00000102897.2 ENSMUST00000102897.3 ENSMUST00000102897.4 ENSMUST00000102897.5 ENSMUST00000102897.6 ENSMUST00000102897.7 ENSMUST00000102897.8 ENSMUST00000102897.9 NM_026132 Q69AB2 Q78Y03 Q80YE0 Q9CQ96 Sptrx3 TXND8_MOUSE Trx6 uc008syq.1 uc008syq.2 uc008syq.3 May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm (By similarity). Cytoplasm Golgi apparatus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69AB2-1; Sequence=Displayed; Name=2; IsoId=Q69AB2-2; Sequence=VSP_014334; Testis-specific. Only expressed during spermiogenesis, prominently in the Golgi apparatus of pachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosome of round spermatids (at protein level). First expressed after puberty. Belongs to the thioredoxin family. Sequence=BAB24702.2; Type=Erroneous initiation; Evidence=; acrosomal vesicle cytoplasm Golgi apparatus multicellular organism development spermatogenesis cell differentiation sperm flagellum cell redox homeostasis uc008syq.1 uc008syq.2 uc008syq.3 
ENSMUST00000102898.5 Rpl7a ENSMUST00000102898.5 ribosomal protein L7A, transcript variant 1 (from RefSeq NM_013721.4) ENSMUST00000102898.1 ENSMUST00000102898.2 ENSMUST00000102898.3 ENSMUST00000102898.4 NM_013721 Q58ET1 Q58ET1_MOUSE Rpl7a uc008iwf.1 uc008iwf.2 uc008iwf.3 Component of the ribosome. Cytoplasm Belongs to the eukaryotic ribosomal protein eL8 family. ribosome ribosome biogenesis ribonucleoprotein complex uc008iwf.1 uc008iwf.2 uc008iwf.3 
ENSMUST00000102900.2 Abo ENSMUST00000102900.2 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase, transcript variant 1 (from RefSeq NM_030718.6) A2AL98 BGAT_MOUSE ENSMUST00000102900.1 NM_030718 P38649 Q8BZH3 Q8BZQ6 Q9EQW2 Q9EQW3 uc008iwb.1 uc008iwb.2 uc008iwb.3 uc008iwb.4 Reaction=an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP- N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl- (1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP; Xref=Rhea:RHEA:19021, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:140327, ChEBI:CHEBI:140559; EC=2.4.1.40; Evidence=; Reaction=an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP- alpha-D-galactose = an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl- (1->2)]-beta-D-galactosyl derivative + H(+) + UDP; Xref=Rhea:RHEA:14349, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:140327, ChEBI:CHEBI:140328; EC=2.4.1.37; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mn(2+) ion per subunit. ; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity). Submaxillary glands (at protein level). The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis. Belongs to the glycosyltransferase 6 family. Sequence=CAM23695.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding alpha-1,3-galactosyltransferase activity antigen binding glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity fucosylgalactoside 3-alpha-galactosyltransferase activity extracellular region Golgi apparatus carbohydrate metabolic process protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups manganese ion binding lipid glycosylation cytoplasmic vesicle vesicle Golgi cisterna membrane metal ion binding uc008iwb.1 uc008iwb.2 uc008iwb.3 uc008iwb.4 
ENSMUST00000102905.8 Pakap ENSMUST00000102905.8 paralemmin A kinase anchor protein, transcript variant 7 (from RefSeq NM_001384149.1) A2APJ4 AKAP2_MOUSE Akap2 ENSMUST00000102905.1 ENSMUST00000102905.2 ENSMUST00000102905.3 ENSMUST00000102905.4 ENSMUST00000102905.5 ENSMUST00000102905.6 ENSMUST00000102905.7 NM_001384149 O54931 O54932 O54933 Pakap Palm2 Palm2akap2 Q8BR92 Q8C5W1 uc290mxb.1 uc290mxb.2 This locus represents naturally occurring readthrough transcription between the neighboring Palm2 (paralemmin 2) and Akap2 (A kinase (PRKA) anchor protein 2) genes on chromosome 4. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Similar readthrough transcription has also been observed in human, as described in PMID: 11478809. [provided by RefSeq, Feb 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## Binds to regulatory subunit (RII) of protein kinase A (PubMed:9497389). May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (PubMed:9497389). Binds tp and modulates the structure of the actin cytoskeleton (PubMed:9497389). O54931-3; P12367: Prkar2a; NbExp=3; IntAct=EBI-645828, EBI-645747; Apical cell membrane ; Lipid-anchor, GPI-like-anchor ; Cytoplasmic side Note=Accumulates near the inner, apical surface of highly polarized epithelium in tubules of nephrons. Event=Alternative splicing, Alternative initiation; Named isoforms=7; Name=6; IsoId=O54931-6; Sequence=Displayed; Name=1; Synonyms=KL1A; IsoId=O54931-1; Sequence=VSP_062024; Name=2; Synonyms=KL2A; IsoId=O54931-2; Sequence=VSP_062024, VSP_062029; Name=3; Synonyms=KL3A; IsoId=O54931-3; Sequence=VSP_062024, VSP_062027, VSP_062028; Name=4; Synonyms=KL1B; IsoId=O54931-4; Sequence=VSP_062023; Name=5; Synonyms=KL2B; IsoId=O54931-5; Sequence=VSP_062023, VSP_062029; Name=7; Synonyms=Palm2, Paralemmin-2; IsoId=O54931-7; Sequence=VSP_062025, VSP_062026; Highly expressed in lung and weakly in thymus and cerebellum (PubMed:9497389). Little or no expression in liver, heart and cerebral cortex (PubMed:9497389). All isoforms are expressed in lung, but KL2A and KL2B isoforms are the principal isoforms in cerebellum (PubMed:9497389). The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. [Isoform 2]: Produced by alternative splicing. [Isoform 3]: Produced by alternative splicing. [Isoform 4]: Produced by alternative initiation at Met- 321 of isoform KL1A. [Isoform 5]: Produced by alternative initiation at Met- 321 of isoform KL2A. Sequence=AAC02206.1; Type=Frameshift; Evidence=; Sequence=AAC02207.1; Type=Frameshift; Evidence=; protein binding uc290mxb.1 uc290mxb.2 
ENSMUST00000102909.8 Sun3 ENSMUST00000102909.8 Sad1 and UNC84 domain containing 3, transcript variant 2 (from RefSeq NM_177576.3) ENSMUST00000102909.1 ENSMUST00000102909.2 ENSMUST00000102909.3 ENSMUST00000102909.4 ENSMUST00000102909.5 ENSMUST00000102909.6 ENSMUST00000102909.7 NM_177576 Q5SS91 Q8BHY0 SUN3_MOUSE Sunc1 uc007hzu.1 uc007hzu.2 As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. Self-associates. Interacts with SYNE1 and SPAG4/SUN4. Proposed to form a spermatogenesis-specific LINC complex with SYNE1 during sperm head formation possibly implicating a SUN domain-based heterotrimer with SPAG4/SUN4 associating with SYNE1. Can interact with SYNE3; the interaction is questioned by missing colocalization in spermatids. Membrane ; Single-pass membrane protein Nucleus envelope Nucleus inner membrane Note=Localized to spermatid nucleus posterior pole lateral regions excluding the implantation fossa during entire sperm head elongation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SS91-1; Sequence=Displayed; Name=2; IsoId=Q5SS91-2; Sequence=VSP_029750; Specifically expressed in testis (at protein level). Exclusively expressed in postmeiotic stages of male germ cell development. First detected at day 25 p.p. when spermatids are most frequent within seminiferous tubules. protein binding nucleus nuclear envelope nuclear inner membrane nuclear envelope organization membrane integral component of membrane LINC complex protein anchor cytoskeletal anchoring at nuclear membrane uc007hzu.1 uc007hzu.2 
ENSMUST00000102910.4 Wap ENSMUST00000102910.4 whey acidic protein (from RefSeq NM_011709.5) ENSMUST00000102910.1 ENSMUST00000102910.2 ENSMUST00000102910.3 NM_011709 Q7M748 Q7M748_MOUSE Wap uc007hzb.1 uc007hzb.2 uc007hzb.3 extracellular region negative regulation of peptidase activity peptidase inhibitor activity uc007hzb.1 uc007hzb.2 uc007hzb.3 
ENSMUST00000102917.11 Col15a1 ENSMUST00000102917.11 collagen, type XV, alpha 1 (from RefSeq NM_009928.3) A2AJY3 COFA1_MOUSE ENSMUST00000102917.1 ENSMUST00000102917.10 ENSMUST00000102917.2 ENSMUST00000102917.3 ENSMUST00000102917.4 ENSMUST00000102917.5 ENSMUST00000102917.6 ENSMUST00000102917.7 ENSMUST00000102917.8 ENSMUST00000102917.9 NM_009928 O35206 Q3UZ71 Q9EQD9 uc008sum.1 uc008sum.2 uc008sum.3 Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. Restin potently inhibits angiogenesis. Trimer; disulfide-linked. [Restin]: Interacts moderately with EFEMP2. Secreted, extracellular space, extracellular matrix Secreted Detected in testis, brain, heart, kidney, skeletal muscle and skin (at protein level). Detected in heart and skeletal muscle. Detected at low levels from day 7 to 11 of embryonic development. Levels are much increased and remain high from day 15 to 17. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. O-glycosylated; contains chondroitin sulfate. Belongs to the multiplexin collagen family. The name Restin has also been used for CAP-Gly domain- containing linker protein 1 the product of the CLIP1 gene. structural molecule activity extracellular matrix structural constituent extracellular region collagen trimer basement membrane extracellular space cell adhesion extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix uc008sum.1 uc008sum.2 uc008sum.3 
ENSMUST00000102919.4 Abca2 ENSMUST00000102919.4 ATP-binding cassette, sub-family A member 2, transcript variant 1 (from RefSeq NM_007379.3) A2AJ26 A2AJ26_MOUSE Abca2 ENSMUST00000102919.1 ENSMUST00000102919.2 ENSMUST00000102919.3 NM_007379 uc008isc.1 uc008isc.2 uc008isc.3 Membrane ; Multi- pass membrane protein nucleotide binding ATP binding lysosome endosome plasma membrane regulation of transcription from RNA polymerase II promoter regulation of cholesterol esterification membrane integral component of membrane ATPase activity regulation of intracellular cholesterol transport negative regulation of intracellular cholesterol transport positive regulation of low-density lipoprotein particle receptor catabolic process ATPase activity, coupled to transmembrane movement of substances cholesterol homeostasis positive regulation of amyloid precursor protein biosynthetic process sphingosine biosynthetic process response to steroid hormone transmembrane transport response to cholesterol negative regulation of phospholipid biosynthetic process negative regulation of sphingolipid biosynthetic process cellular sphingolipid homeostasis negative regulation of cholesterol efflux ceramide-translocating ATPase activity ceramide translocation regulation of post-translational protein modification positive regulation of beta-amyloid formation positive regulation of amyloid precursor protein catabolic process negative regulation of low-density lipoprotein receptor activity negative regulation of receptor-mediated endocytosis involved in cholesterol transport uc008isc.1 uc008isc.2 uc008isc.3 
ENSMUST00000102920.4 Gck ENSMUST00000102920.4 glucokinase, transcript variant 1 (from RefSeq NM_010292.5) ENSMUST00000102920.1 ENSMUST00000102920.2 ENSMUST00000102920.3 Gck NM_010292 Q5SVI5 Q5SVI5_MOUSE uc007hxn.1 uc007hxn.2 uc007hxn.3 uc007hxn.4 uc007hxn.5 Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+); Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826; Evidence=; Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+); Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741; Evidence=; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 1/4. Carbohydrate metabolism; hexose metabolism. Belongs to the hexokinase family. nucleotide binding cellular glucose homeostasis glucokinase activity hexokinase activity ATP binding glucose binding cytosol carbohydrate metabolic process glycolytic process kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor positive regulation of insulin secretion glucose homeostasis negative regulation of gluconeogenesis positive regulation of glycogen biosynthetic process carbohydrate phosphorylation regulation of insulin secretion glucose 6-phosphate metabolic process detection of glucose uc007hxn.1 uc007hxn.2 uc007hxn.3 uc007hxn.4 uc007hxn.5 
ENSMUST00000102921.4 Myl7 ENSMUST00000102921.4 myosin, light polypeptide 7, regulatory (from RefSeq NM_022879.2) ENSMUST00000102921.1 ENSMUST00000102921.2 ENSMUST00000102921.3 MLRA_MOUSE Mylc2a NM_022879 Q63977 Q9JIE8 Q9QVP4 uc007hxl.1 uc007hxl.2 Myosin is a hexamer of 2 heavy chains and 4 light chains. Predominantly expressed in adult atrial muscle. This chain binds calcium. calcium ion binding protein binding myosin complex A band dendritic spine metal ion binding uc007hxl.1 uc007hxl.2 
ENSMUST00000102922.10 Pold2 ENSMUST00000102922.10 polymerase (DNA directed), delta 2, regulatory subunit, transcript variant 1 (from RefSeq NM_008894.2) DPOD2_MOUSE ENSMUST00000102922.1 ENSMUST00000102922.2 ENSMUST00000102922.3 ENSMUST00000102922.4 ENSMUST00000102922.5 ENSMUST00000102922.6 ENSMUST00000102922.7 ENSMUST00000102922.8 ENSMUST00000102922.9 NM_008894 O35654 Q99J61 uc007hxk.1 uc007hxk.2 uc007hxk.3 uc007hxk.4 Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Pol-delta3 and Pol- delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol- delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7. Component of both the DNA polymerase delta and DNA polymerase zeta complexes. Component of the tetrameric DNA polymerase delta complex (Pol-delta4), which consists of POLD1/p125, POLD2/p50, POLD3/p66/p68 and POLD4/p12, with POLD1 bearing DNA polymerase and 3' to 5' proofreading exonuclease activities. Within Pol-delta4, directly interacts with POLD1, POLD3 and POLD4. Following stress caused by DNA damaging agents or by replication stress, POLD4 is degraded and Pol- delta4 is converted into a trimeric form of the complex (Pol-delta3), which consists of POLD1, POLD2 and POLD3. Pol-delta3 is the major form occurring at S phase replication sites, as well as DNA damage sites. Also observed as a dimeric complex with POLD2 (Pol-delta2 complex). Pol-delta2 is relatively insensitive to the PCNA stimulation (2-5-fold) compared to Pol-delta4 that is stimulated by over 50-fold. Contrary to the other components of Pol-delta4, does not directly interact with PCNA. As POLD1 and POLD4, directly interacts with WRNIP1; this interaction stimulates DNA polymerase delta-mediated DNA synthesis, independently of the presence of PCNA. This stimulation may be due predominantly to an increase of initiation frequency and also to increased processivity. Directly interacts with POLDIP2 and POLDIP3. Directly interacts with KCTD13/PDIP1; in the presence of PCNA, this interaction may stimulate DNA polymerase activity. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3, with REV3L bearing DNA polymerase catalytic activity (By similarity). Interacts with KCTD10 (By similarity). Nucleus Note=Recruited to DNA damage sites within 2 hours following UV irradiation. Belongs to the DNA polymerase delta/II small subunit family. DNA binding DNA-directed DNA polymerase activity nucleus nucleoplasm DNA replication DNA-dependent DNA replication DNA strand elongation involved in DNA replication DNA repair cellular response to DNA damage stimulus delta DNA polymerase complex DNA biosynthetic process uc007hxk.1 uc007hxk.2 uc007hxk.3 uc007hxk.4 
ENSMUST00000102923.10 Aebp1 ENSMUST00000102923.10 AE binding protein 1, transcript variant 2 (from RefSeq NM_009636.3) AEBP1_MOUSE Aclp ENSMUST00000102923.1 ENSMUST00000102923.2 ENSMUST00000102923.3 ENSMUST00000102923.4 ENSMUST00000102923.5 ENSMUST00000102923.6 ENSMUST00000102923.7 ENSMUST00000102923.8 ENSMUST00000102923.9 NM_009636 O88442 Q3TVV5 Q3TWA7 Q3TX56 Q3TXB2 Q5NCI9 Q61281 Q640N1 uc007hxg.1 uc007hxg.2 uc007hxg.3 uc007hxg.4 uc007hxg.5 [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix. [Isoform 2]: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Isoform 1: Interacts with different types of collagen, including collagens I, III, and V (By similarity). Isoform 2: Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. Interaction with MAPK1 may stimulate DNA-binding. May interact with calmodulin. Binds to DNA in vitro. [Isoform 1]: Secreted [Isoform 2]: Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Aclp; IsoId=Q640N1-1; Sequence=Displayed; Name=2; Synonyms=Aebp1; IsoId=Q640N1-2; Sequence=VSP_033470; Isoform 1 and isoform 2 are expressed in adipose tissue, brain, heart, kidney, liver, lung, skeletal muscle, small intestine, spleen and testis. Isoform 2 is expressed in macrophages. Expressed in aorta, preadipocytes, adipocyte tissue, brain, heart, liver, lung, skeletal muscle, skin and spleen (at protein level). Expressed in the somites and dorsa from 9.5 dpc and in the yolk sac and embryonic vasculature from 10.5 dpc. Expression within the large and small blood vessels increases at 11.5 dpc and 13.5 dpc, with high expression in the vascular smooth muscle at 16.5 dpc. Also expressed later in development in mesenchymal cells in the dermal layer, the developing skeleton, connective tissue and the umbilical ring and vessels. Up-regulated during vascular smooth muscle cell differentiation and down-regulated during adipocyte differentiation and osteoblast differentiation. By TGF-beta. Expression is also induced by a high fat diet. [Isoform 1]: The F5/8 type C domain binds to different types of collagen, including collagens I, III, and V. Phosphorylated by MAPK1 in vitro. Two independent knockout mice have been generated for the gene encoding this protein, and these exhibit different phenotypes. Mice lacking exons 7-12 exhibit reduced growth rate and body weight and resistance to dietary-induced obesity. Individual adipocytes from these animals are hypoproliferative while the adipose tissue is prone to apoptosis. Mice lacking exons 7-16 die perinatally from gastroschisis, in which abdominal viscera are extruded through the ventral body wall. Surviving mice exhibit deficient wound healing, having dermal fibroblasts with reduced proliferative capacity. Mice lacking exons 7-16 may exhibit phenotypes arising from effects on the locus encoding Pold2, which lies immediately downstream of this locus. Belongs to the peptidase M14 family. Although related to peptidase M14 family, lacks the active site residues and zinc-binding sites, suggesting that it has no carboxypeptidase activity. Sequence=CAA56648.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription corepressor activity carboxypeptidase activity metallocarboxypeptidase activity calmodulin binding collagen binding extracellular region extracellular space nucleus cytoplasm regulation of transcription, DNA-templated proteolysis peptide metabolic process zinc ion binding protein processing regulation of collagen fibril organization uc007hxg.1 uc007hxg.2 uc007hxg.3 uc007hxg.4 uc007hxg.5 
ENSMUST00000102925.4 Uap1l1 ENSMUST00000102925.4 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1, transcript variant 2 (from RefSeq NR_149315.1) A1L3D3 ENSMUST00000102925.1 ENSMUST00000102925.2 ENSMUST00000102925.3 NR_149315 Q3TW96 Q6KAP8 Q6NVB6 Q80XP4 UAP1L_MOUSE uc008irr.1 uc008irr.2 uc008irr.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TW96-1; Sequence=Displayed; Name=2; IsoId=Q3TW96-2; Sequence=VSP_032281; Belongs to the UDPGP type 1 family. Sequence=AAH43307.1; Type=Erroneous initiation; Evidence=; Sequence=BAD21409.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence=; UDP-N-acetylglucosamine diphosphorylase activity UDP-N-acetylglucosamine biosynthetic process transferase activity nucleotidyltransferase activity uridylyltransferase activity uc008irr.1 uc008irr.2 uc008irr.3 
ENSMUST00000102926.5 Anp32b ENSMUST00000102926.5 acidic nuclear phosphoprotein 32 family member B (from RefSeq NM_130889.3) AN32B_MOUSE B1AVH9 ENSMUST00000102926.1 ENSMUST00000102926.2 ENSMUST00000102926.3 ENSMUST00000102926.4 NM_130889 Pal31 Q566J4 Q9EST5 uc008stt.1 uc008stt.2 uc008stt.3 Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:21636789). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (By similarity). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (By similarity). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (By similarity). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (PubMed:30890743). Interacts with histones H3 and H4. Interacts with KLF5; this interaction induces promoter region-specific histone incorporation and inhibition of histone acetylation by ANP32B. Nucleus Note=Accumulates in the nuclei at the S phase. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EST5-1; Sequence=Displayed; Name=2; IsoId=Q9EST5-2; Sequence=VSP_023520, VSP_023521; Histone binding is mediated by the concave surface of the LRR region. Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group. Directly cleaved by caspase-3/CASP3. Deficient mice display an highly penetrant perinatal lethality in a mixed genetic background and a fully penetrant lethality in a pure C57BL/6 background (PubMed:21636789). Mutants also show enhanced clinical symptoms correlated with depletion of naive effector T-cells, exhaustion of lymphocytes and enhanced prevalence of follicular T-helper cells (PubMed:30890743). In addition, mice show significantly reduced H3N2 or H5N1 influenza viral loads, inflammatory cytokine response and reduced pathogenicity compared to WT (PubMed:32231671). Belongs to the ANP32 family. G1/S transition of mitotic cell cycle vasculature development nucleus nucleolus cytoplasm nucleosome assembly activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cell proliferation ventricular system development histone binding negative regulation of apoptotic process negative regulation of cell differentiation positive regulation of protein export from nucleus inner ear development palate development RNA polymerase binding positive regulation of G1/S transition of mitotic cell cycle uc008stt.1 uc008stt.2 uc008stt.3 
ENSMUST00000102927.10 Pdpk1 ENSMUST00000102927.10 3-phosphoinositide dependent protein kinase 1, transcript variant 1 (from RefSeq NM_011062.4) A6H6U3 ENSMUST00000102927.1 ENSMUST00000102927.2 ENSMUST00000102927.3 ENSMUST00000102927.4 ENSMUST00000102927.5 ENSMUST00000102927.6 ENSMUST00000102927.7 ENSMUST00000102927.8 ENSMUST00000102927.9 NM_011062 PDPK1_MOUSE Pdk1 Q9R1D8 Q9R215 Q9Z2A0 uc012amc.1 uc012amc.2 uc012amc.3 Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Homodimerization regulates its activity by maintaining the kinase in an autoinhibitory conformation. NPRL2 down- regulates its activity by interfering with tyrosine phosphorylation at the Tyr-9, Tyr-376 and Tyr-379 residues. The 14-3-3 protein YWHAQ acts as a negative regulator by association with the residues surrounding the Ser-244 residue. STRAP positively regulates its activity by enhancing its autophosphorylation and by stimulating its dissociation from YWHAQ. SMAD2, SMAD3, SMAD4 and SMAD7 also positively regulate its activity by stimulating its dissociation from YWHAQ. Activated by phosphorylation on Tyr-9, Tyr-376 and Tyr-379 by INSR in response to insulin (By similarity). Homodimer in its autoinhibited state. Active as monomer. Interacts with NPRL2, PAK1, PTK2B, GRB14, STRAP and IKKB. The Tyr-9 phosphorylated form interacts with SRC, RASA1 and CRK (via their SH2 domains). Interacts with SGK3 in a phosphorylation-dependent manner. The tyrosine-phosphorylated form interacts with PTPN6. The Ser-244 phosphorylated form interacts with YWHAH and YWHAQ. Binds INSR in response to insulin. Interacts (via PH domain) with SMAD3, SMAD4 and SMAD7. Interacts with PKN2; the interaction stimulates PDPK1 autophosphorylation, its PI(3,4,5)P3-dependent kinase activity toward 'Ser-473' of AKT1 but also activates its kinase activity toward PRKCD and PRKCZ (By similarity). Interacts with PKN1 (via C-terminus) and PPARG. Cytoplasm Nucleus Cell membrane ; Peripheral membrane protein Cell junction, focal adhesion Note=Tyrosine phosphorylation seems to occur only at the cell membrane. Translocates to the cell membrane following insulin stimulation by a mechanism that involves binding to GRB14 and INSR. SRC and HSP90 promote its localization to the cell membrane. Its nuclear localization is dependent on its association with PTPN6 and its phosphorylation at Ser-396. Restricted to the nucleus in neuronal cells while in non-neuronal cells it is found in the cytoplasm. The Ser-244 phosphorylated form is distributed along the perinuclear region in neuronal cells while in non-neuronal cells it is found in both the nucleus and the cytoplasm. IGF1 transiently increases phosphorylation at Ser-241 of neuronal PDPK1, resulting in its translocation to other cellular compartments. The tyrosine-phosphorylated form colocalizes with PTK2B in focal adhesions after angiotensin II stimulation (By similarity). Highly expressed in heart, brain, liver and testis, also expressed in embryonic cells. The PH domain plays a pivotal role in the localization and nuclear import of PDPK1 and is also essential for its homodimerization. The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors. Phosphorylation on Ser-244 in the activation loop is required for full activity. PDPK1 itself can autophosphorylate Ser-244, leading to its own activation. Autophosphorylation is inhibited by the apoptotic C-terminus cleavage product of PKN2 (By similarity). Tyr-9 phosphorylation is critical for stabilization of both PDPK1 and the PDPK1/SRC complex via HSP90-mediated protection of PDPK1 degradation. Angiotensin II stimulates the tyrosine phosphorylation of PDPK1 in vascular smooth muscle in a calcium- and SRC-dependent manner. Phosphorylated on Tyr-9, Tyr-376 and Tyr-379 by INSR in response to insulin. Palmitate negatively regulates autophosphorylation at Ser-244 and palmitate-induced phosphorylation at Ser-532 and Ser-504 by PKC/PRKCQ negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylation at Thr-357 by MELK partially inhibits kinase activity, the inhibition is cooperatively enhanced by phosphorylation at Ser-397 and Ser-401 by MAP3K5 (By similarity). Monoubiquitinated in the kinase domain, deubiquitinated by USP4. Mice show severe pancreatic hypoplasia at birth and ensuing hyperglycemia at postnatal stages and die of heart failure by 11 weeks of age. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. nucleotide binding type B pancreatic cell development protein kinase activity protein serine/threonine kinase activity 3-phosphoinositide-dependent protein kinase activity insulin receptor binding protein binding ATP binding nucleus cytoplasm cytosol plasma membrane focal adhesion protein phosphorylation negative regulation of protein kinase activity hyperosmotic response signal transduction epidermal growth factor receptor signaling pathway positive regulation of phospholipase activity regulation of endothelial cell migration negative regulation of cardiac muscle cell apoptotic process postsynaptic density phospholipase activator activity membrane kinase activity phosphorylation cell migration transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation calcium-mediated signaling protein kinase binding cell junction negative regulation of transforming growth factor beta receptor signaling pathway cytoplasmic vesicle activation of protein kinase B activity cellular response to insulin stimulus negative regulation of toll-like receptor signaling pathway intracellular signal transduction cell projection regulation of I-kappaB kinase/NF-kappaB signaling perikaryon phospholipase binding regulation of mast cell degranulation negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis focal adhesion assembly positive regulation of release of sequestered calcium ion into cytosol cellular response to epidermal growth factor stimulus extrinsic apoptotic signaling pathway positive regulation of protein localization to plasma membrane positive regulation of sprouting angiogenesis positive regulation of vascular endothelial cell proliferation cellular response to brain-derived neurotrophic factor stimulus negative regulation of endothelial cell apoptotic process uc012amc.1 uc012amc.2 uc012amc.3 
ENSMUST00000102928.5 Dbnl ENSMUST00000102928.5 drebrin-like, transcript variant 2 (from RefSeq NM_013810.3) Abp1 DBNL_MOUSE Dbnl ENSMUST00000102928.1 ENSMUST00000102928.2 ENSMUST00000102928.3 ENSMUST00000102928.4 NM_013810 Q3TG34 Q3U5X3 Q3U8I5 Q3UZ33 Q5NCI5 Q5NCI6 Q5NCI7 Q62418 Q80WP1 Q8BH56 Sh3p7 uc007hxb.1 uc007hxb.2 uc007hxb.3 uc007hxb.4 Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Interacts with SHANK3, SYN1 and PRAM1 (By similarity). Interacts with SHANK2. Interacts with FGD1, DNM1 and MAP4K1. Interacts with ANKRD54. Interacts with COBL. Interacts with WASL and WIPF1. Cytoplasm, cytoskeleton ll projection, lamellipodium Cell projection, ruffle Cytoplasm, cell cortex toplasm, cytosol Synapse Perikaryon Cell projection, neuron projection Cell membrane ; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane ; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome Early endosome Cell projection, dendrite Postsynaptic density Note=Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes. Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q62418-1; Sequence=Displayed; Name=2 ; IsoId=Q62418-2; Sequence=VSP_050790; Name=3 ; IsoId=Q62418-3; Sequence=VSP_050789; Detected in hippocampus neurons and in the Purkinje cell layer in cerebellum (at protein level). Predominantly expressed in brain, thymus and spleen. Also found in testis, heart and lung. Little or no expression detected in ovary or muscle. In the embryo, expression is high during early development but drops during later development. The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1. Belongs to the ABP1 family. Golgi membrane ruffle podosome adaptive immune response immune system process actin binding protein binding cytoplasm endosome early endosome Golgi apparatus cytosol cytoskeleton plasma membrane cell cortex endocytosis receptor-mediated endocytosis synapse assembly protein C-terminus binding postsynaptic density membrane Rac protein signal transduction protein domain specific binding lamellipodium cell junction dendrite site of polarized growth clathrin-coated vesicle membrane regulation of actin filament polymerization cortical actin cytoskeleton cytoplasmic vesicle cell projection synapse postsynaptic membrane positive regulation of axon extension neuron projection morphogenesis actin filament binding positive regulation of dendritic spine morphogenesis podosome assembly ruffle assembly postsynaptic actin cytoskeleton organization actin filament actin filament severing barbed-end actin filament capping actin filament bundle assembly uc007hxb.1 uc007hxb.2 uc007hxb.3 uc007hxb.4 
ENSMUST00000102929.2 Tdrd7 ENSMUST00000102929.2 tudor domain containing 7, transcript variant 2 (from RefSeq NM_146142.2) B1AWG7 B1AWH5 ENSMUST00000102929.1 NM_146142 Pctaire2bp Q8K1H1 Q8R181 TDRD7_MOUSE uc008stc.1 uc008stc.2 uc008stc.3 uc008stc.4 Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis. Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1. Cytoplasm Note=Localizes to cytoplasmic RNA granules. Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids. Mainly expressed in testis. Expressed in spermatogonia, spermatocytes and round spermatids (at protein level). Also expressed in the developing lens. At 12.5 dpc, it is expressed in differentiating fiber cells in the posterior lens, but not in the anterior epithelium of the lens (AEL). Mice develop cataracts and glaucoma and males are sterile. Within 4 weeks of birth, mice develop a posterior cataract that becomes severe with age. At later stages, the lens fiber cell compartment develops vacuoles with lens capsule rupture and extrusion of fiber cell mass into the vitreous. In addition, the mass of fiber cells passes through the pupil into the anterior chamber of the eye. By 4 months of age, iris flattening is detected and anterior chamber depth increased. By 6 months of age, the intraocular pressure (IOP) is elevated in some mutants, and the incidence of elevated IOP increases with age, leading to glaucome. Severe optic nerve atrophy characterized by retinal ganglion cell axon loss and excavative remodeling of the optic nerve are observed. In addition, males display sterility due to an arrest in spermatogenesis at the round spermatid stage, likely due to a chromatoid body defect. Belongs to the TDRD7 family. Sequence=CAM17034.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM22130.1; Type=Erroneous gene model prediction; Evidence=; lens morphogenesis in camera-type eye RNA binding mRNA binding protein binding cytoplasm mitochondrial matrix multicellular organism development germ cell development spermatogenesis posttranscriptional regulation of gene expression cell differentiation chromatoid body ribonucleoprotein granule P granule protein N-terminus binding lens fiber cell differentiation ribonucleoprotein complex uc008stc.1 uc008stc.2 uc008stc.3 uc008stc.4 
ENSMUST00000102936.9 Gne ENSMUST00000102936.9 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase, transcript variant 3 (from RefSeq NM_001357539.1) ENSMUST00000102936.1 ENSMUST00000102936.2 ENSMUST00000102936.3 ENSMUST00000102936.4 ENSMUST00000102936.5 ENSMUST00000102936.6 ENSMUST00000102936.7 ENSMUST00000102936.8 GLCNE_MOUSE Glcne Gne NM_001357539 Q8CC83 Q8CCB0 Q91WG8 Q9Z0P6 Uae1 uc008srn.1 uc008srn.2 uc008srn.3 uc008srn.4 Bifunctional enzyme that possesses both UDP-N- acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities, and serves as the initiator of the biosynthetic pathway leading to the production of N-acetylneuraminic acid (NeuAc), a critical precursor in the synthesis of sialic acids. By catalyzing this pivotal and rate-limiting step in sialic acid biosynthesis, this enzyme assumes a pivotal role in governing the regulation of cell surface sialylation (PubMed:11929971). Sialic acids represent a category of negatively charged sugars that reside on the surface of cells as terminal components of glycoconjugates and mediate important functions in various cellular processes, including cell adhesion, signal transduction, and cellular recognition (By similarity). Reaction=H2O + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-D- mannosamine + UDP; Xref=Rhea:RHEA:30683, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17122, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223; EC=3.2.1.183; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30684; Evidence=; Reaction=an N-acyl-D-mannosamine + ATP = ADP + an N-acyl-D-mannosamine 6-phosphate + H(+); Xref=Rhea:RHEA:23832, ChEBI:CHEBI:15378, ChEBI:CHEBI:16062, ChEBI:CHEBI:30616, ChEBI:CHEBI:57666, ChEBI:CHEBI:456216; EC=2.7.1.60; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23833; Evidence=; The UDP-N-acetylglucosamine 2-epimerase activity, in contrast to the N-acetylmannosamine kinase activity, exhibits allosteric regulation by cytidine monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac), the end product of neuraminic acid biosynthesis (By similarity). Moreover, the activity is contingent upon the oligomeric state of the enzyme. The monomeric form is inactive, while the dimeric form selectively catalyzes the phosphorylation of N-acetylmannosamine. The hexameric form, on the other hand, demonstrates full proficiency in both enzyme activities (By similarity). Furthermore, the UDP-N- acetylglucosamine 2-epimerase activity is increased by PKC-mediated phosphorylation (PubMed:10745088). Amino-sugar metabolism; N-acetylneuraminate biosynthesis. Homodimer. Homotetramer. Homohexamer (By similarity). The hexameric form exhibits both enzyme activities, whereas the dimeric form only catalyzes the phosphorylation of N-acyl-D-mannosamine (By similarity). Cytoplasm, cytosol Widely expressed. Highest expression in liver. Also found at high levels in lung, brain and kidney. In the embryo, expressed at day 7 dpc, 11 dpc and 15 dpc. Phosphorylated. Phosphorylation by PKC activates the UDP-N- acetylglucosamine 2-epimerase activity. Knockout of the gene is embryonic lethal. In the N-terminal section; belongs to the UDP-N- acetylglucosamine 2-epimerase family. In the C-terminal section; belongs to the ROK (NagC/XylR) family. nucleotide binding catalytic activity hydrolase activity, hydrolyzing O-glycosyl compounds ATP binding cytoplasm cytosol N-acetylglucosamine biosynthetic process UDP-N-acetylglucosamine metabolic process N-acetylneuraminate metabolic process metabolic process UDP-N-acetylglucosamine 2-epimerase activity N-acylmannosamine kinase activity kinase activity phosphorylation transferase activity hydrolase activity carbohydrate phosphorylation metal ion binding uc008srn.1 uc008srn.2 uc008srn.3 uc008srn.4 
ENSMUST00000102942.8 Psd4 ENSMUST00000102942.8 pleckstrin and Sec7 domain containing 4, transcript variant 1 (from RefSeq NM_001355231.1) A2AIU4 ENSMUST00000102942.1 ENSMUST00000102942.2 ENSMUST00000102942.3 ENSMUST00000102942.4 ENSMUST00000102942.5 ENSMUST00000102942.6 ENSMUST00000102942.7 Efa6b NM_001355231 PSD4_MOUSE Q3TE33 Q3TQF5 Q3UD59 Q3UFH9 Q80V44 Q8BLR5 uc008ioy.1 uc008ioy.2 uc008ioy.3 Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II- containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate (By similarity). Cell membrane Cell projection, ruffle membrane Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions. Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures. Recruited to membranes via phosphatidylinositol phosphate-binding. Sequence=BAE29402.1; Type=Erroneous initiation; Evidence=; guanyl-nucleotide exchange factor activity ARF guanyl-nucleotide exchange factor activity plasma membrane lipid binding membrane regulation of ARF protein signal transduction ruffle membrane cell projection uc008ioy.1 uc008ioy.2 uc008ioy.3 
ENSMUST00000102943.2 Hus1b ENSMUST00000102943.2 HUS1 checkpoint clamp component B (from RefSeq NM_153072.2) ENSMUST00000102943.1 HUS1B_MOUSE NM_153072 Q8K572 uc007pzf.1 uc007pzf.2 uc007pzf.3 uc007pzf.4 Interacts with RAD1 and RAD9B. Belongs to the HUS1 family. DNA damage checkpoint telomere maintenance double-strand break repair via homologous recombination molecular_function nucleolus nucleotide-excision repair checkpoint clamp complex intra-S DNA damage checkpoint mitotic DNA replication checkpoint site of double-strand break meiotic DNA integrity checkpoint uc007pzf.1 uc007pzf.2 uc007pzf.3 uc007pzf.4 
ENSMUST00000102944.11 Creb3 ENSMUST00000102944.11 cAMP responsive element binding protein 3 (from RefSeq NM_013497.4) Creb3 ENSMUST00000102944.1 ENSMUST00000102944.10 ENSMUST00000102944.2 ENSMUST00000102944.3 ENSMUST00000102944.4 ENSMUST00000102944.5 ENSMUST00000102944.6 ENSMUST00000102944.7 ENSMUST00000102944.8 ENSMUST00000102944.9 NM_013497 Q3UNH6 Q3UNH6_MOUSE uc008sqg.1 uc008sqg.2 uc008sqg.3 Endoplasmic reticulum membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the bZIP family. ATF subfamily. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, sequence-specific DNA binding nucleus endoplasmic reticulum cytosol regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response endoplasmic reticulum unfolded protein response cAMP response element binding positive regulation of transcription from RNA polymerase II promoter positive regulation of monocyte chemotaxis negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway uc008sqg.1 uc008sqg.2 uc008sqg.3 
ENSMUST00000102945.2 Nxph2 ENSMUST00000102945.2 neurexophilin 2 (from RefSeq NM_008752.2) ENSMUST00000102945.1 NM_008752 NXPH2_MOUSE Nph2 Q61199 Q8BIN8 uc008iog.1 uc008iog.2 May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Secreted May be proteolytically processed at the boundary between the N- terminal non-conserved and the central conserved domain in neuron-like cells. Rodents express at detectable levels only neurexophilins-1, -3, and -4. Belongs to the neurexophilin family. receptor binding extracellular region uc008iog.1 uc008iog.2 
ENSMUST00000102955.11 Cetn4 ENSMUST00000102955.11 centrin 4 (from RefSeq NM_145825.2) CETN4_MOUSE Cen4 Cetn4 E9PYP9 E9Q074 ENSMUST00000102955.1 ENSMUST00000102955.10 ENSMUST00000102955.2 ENSMUST00000102955.3 ENSMUST00000102955.4 ENSMUST00000102955.5 ENSMUST00000102955.6 ENSMUST00000102955.7 ENSMUST00000102955.8 ENSMUST00000102955.9 J3KMS3 NM_145825 Q3TLH1 Q5SUE1 Q8BIC4 Q8K4K1 uc008pam.1 uc008pam.2 uc008pam.3 Ca(2+)-binding protein that may be involved in basal body assembly or in a subsequent step of ciliogenesis. Interacts with G-protein beta-gamma dimers in a calcium- dependent manner. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole toplasm te=Accumulates at procentrioles during their elongation. Isoform 3 is not observed in the centriole. Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q8K4K1-1; Sequence=Displayed; Name=2 ; IsoId=Q8K4K1-2; Sequence=VSP_044649; Name=3 ; Synonyms=Splice4A ; IsoId=Q8K4K1-3; Sequence=VSP_044650; In brain, specifically expressed in ciliated cells. In retina, expression is localized to the connecting cilium and basal body of photoreceptors (at protein level). Highly expressed in brain, kidney, lung, retina and ovary, and weakly expressed in spleen. Not detected in testis, colon, stomach, thymus, skeletal muscle, heart, intestine or liver. The fourth EF-hand domain has been proven to bind calcium. Phosphorylated on Thr-134 by casein kinase II (CK2) in a light- dependent manner. Belongs to the centrin family. mitotic cell cycle calcium ion binding cytoplasm centrosome centriole cytoskeleton nucleotide-excision repair centriole replication G-protein beta/gamma-subunit complex binding heterotrimeric G-protein binding ciliary basal body uc008pam.1 uc008pam.2 uc008pam.3 
ENSMUST00000102957.6 Ccl19 ENSMUST00000102957.6 C-C motif chemokine ligand 19 (from RefSeq NM_011888.4) Ccl19 ENSMUST00000102957.1 ENSMUST00000102957.2 ENSMUST00000102957.3 ENSMUST00000102957.4 ENSMUST00000102957.5 NM_011888 Q548P0 Q548P0_MOUSE Scya19 uc008snx.1 uc008snx.2 uc008snx.3 Secreted Belongs to the intercrine beta (chemokine CC) family. cytokine activity extracellular region extracellular space chemotaxis immune response signal transduction chemokine activity cell chemotaxis uc008snx.1 uc008snx.2 uc008snx.3 
ENSMUST00000102962.10 Cntfr ENSMUST00000102962.10 ciliary neurotrophic factor receptor, transcript variant 1 (from RefSeq NM_016673.3) CNTFR_MOUSE ENSMUST00000102962.1 ENSMUST00000102962.2 ENSMUST00000102962.3 ENSMUST00000102962.4 ENSMUST00000102962.5 ENSMUST00000102962.6 ENSMUST00000102962.7 ENSMUST00000102962.8 ENSMUST00000102962.9 NM_016673 O88507 Q80T01 uc008sjf.1 uc008sjf.2 uc008sjf.3 uc008sjf.4 This gene encodes the alpha subunit of the ciliary neurotrophic factor (CNTF) receptor that triggers the assembly of a trimolecular complex upon binding to CNTF, and initiate a downstream signaling process. The encoded preproprotein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-linked cell surface protein. Mice lacking the encoded protein die shortly after birth and exhibit a reduction of motoneuron number at birth. The transgenic disruption of this gene specifically in the skeletal muscle followed by a peripheral nerve lesion impairs motor neuron axonal regeneration across the lesion site. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015]. Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity). Forms a heterotrimer with LIFR and IL6ST. Interacts with heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF- 1. Either alone or in complex with the heterodimer CLCF1-CRLF1 interacts with SORL1; this interaction may promote internalization and lysosomal degradation. Cell membrane ; Lipid-anchor, GPI- anchor The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. Belongs to the type I cytokine receptor family. Type 3 subfamily. suckling behavior brainstem development cytokine receptor activity ciliary neurotrophic factor receptor activity receptor binding protein binding plasma membrane sex differentiation positive regulation of cell proliferation external side of plasma membrane membrane apical plasma membrane cytokine binding anchored component of membrane receptor complex negative regulation of neuron apoptotic process skeletal muscle organ development ciliary neurotrophic factor receptor complex ciliary neurotrophic factor-mediated signaling pathway CNTFR-CLCF1 complex uc008sjf.1 uc008sjf.2 uc008sjf.3 uc008sjf.4 
ENSMUST00000102963.10 Dnai1 ENSMUST00000102963.10 dynein axonemal intermediate chain 1 (from RefSeq NM_175138.4) DNAI1_MOUSE Dnaic1 ENSMUST00000102963.1 ENSMUST00000102963.2 ENSMUST00000102963.3 ENSMUST00000102963.4 ENSMUST00000102963.5 ENSMUST00000102963.6 ENSMUST00000102963.7 ENSMUST00000102963.8 ENSMUST00000102963.9 NM_175138 Q8BKY5 Q8C0M8 uc008sjc.1 uc008sjc.2 uc008sjc.3 uc008sjc.4 Part of the dynein complex of respiratory cilia. Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with BICD2 (By similarity). Interacts with CFAP45 and CFAP52 (By similarity). Cytoplasm, cytoskeleton, cilium axoneme Belongs to the dynein intermediate chain family. cilium movement epithelial cilium movement motor activity protein binding extracellular region cytoplasm centrosome cytoskeleton microtubule cilium microtubule-based movement determination of left/right symmetry heart development insulin receptor signaling pathway dynein complex flagellated sperm motility outer dynein arm outer dynein arm assembly cell projection dynein light chain binding dynein heavy chain binding ATP-dependent microtubule motor activity, plus-end-directed uc008sjc.1 uc008sjc.2 uc008sjc.3 uc008sjc.4 
ENSMUST00000102964.4 H4c1 ENSMUST00000102964.4 H4 clustered histone 1 (from RefSeq NM_178192.2) A0AUM5 A4FUP8 A4QMY0 ENSMUST00000102964.1 ENSMUST00000102964.2 ENSMUST00000102964.3 H4-12 H4-53 H4_MOUSE H4c11 H4c12 H4c14 H4c16 H4c2 H4c3 H4c4 H4c6 H4c8 H4c9 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist1h4m Hist2h4 Hist2h4a Hist4h4 NM_178192 P02304 P02305 P62806 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 uc007pux.1 uc007pux.2 uc007pux.3 uc007pux.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3- H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). P62806; Q8CDM1: Atad2; NbExp=2; IntAct=EBI-299632, EBI-2944582; P62806; Q9EQQ9: Oga; NbExp=2; IntAct=EBI-299632, EBI-8321615; Nucleus Chromosome Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Sumoylated, which is associated with transcriptional repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H4 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly DNA-templated transcription, initiation protein domain specific binding macromolecular complex negative regulation of megakaryocyte differentiation protein heterodimerization activity protein heterotetramerization uc007pux.1 uc007pux.2 uc007pux.3 uc007pux.4 
ENSMUST00000102965.4 H4c2 ENSMUST00000102965.4 H4 clustered histone 2 (from RefSeq NM_178193.2) A0AUM5 A4FUP8 A4QMY0 ENSMUST00000102965.1 ENSMUST00000102965.2 ENSMUST00000102965.3 H4-12 H4-53 H4_MOUSE H4c1 H4c11 H4c12 H4c14 H4c16 H4c3 H4c4 H4c6 H4c8 H4c9 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist1h4m Hist2h4 Hist2h4a Hist4h4 NM_178193 P02304 P02305 P62806 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 uc007puw.1 uc007puw.2 uc007puw.3 uc007puw.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC132186.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3- H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). P62806; Q8CDM1: Atad2; NbExp=2; IntAct=EBI-299632, EBI-2944582; P62806; Q9EQQ9: Oga; NbExp=2; IntAct=EBI-299632, EBI-8321615; Nucleus Chromosome Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Sumoylated, which is associated with transcriptional repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H4 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly DNA-templated transcription, initiation protein domain specific binding macromolecular complex negative regulation of megakaryocyte differentiation protein heterodimerization activity protein heterotetramerization uc007puw.1 uc007puw.2 uc007puw.3 uc007puw.4 
ENSMUST00000102967.3 H4c3 ENSMUST00000102967.3 H4 clustered histone 3 (from RefSeq NM_178208.2) A0AUM5 A4FUP8 A4QMY0 ENSMUST00000102967.1 ENSMUST00000102967.2 H4-12 H4-53 H4_MOUSE H4c1 H4c11 H4c12 H4c14 H4c16 H4c2 H4c4 H4c6 H4c8 H4c9 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist1h4m Hist2h4 Hist2h4a Hist4h4 NM_178208 P02304 P02305 P62806 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 uc007puo.1 uc007puo.2 uc007puo.3 uc007puo.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Sep 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3- H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). P62806; Q8CDM1: Atad2; NbExp=2; IntAct=EBI-299632, EBI-2944582; P62806; Q9EQQ9: Oga; NbExp=2; IntAct=EBI-299632, EBI-8321615; Nucleus Chromosome Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Sumoylated, which is associated with transcriptional repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H4 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly DNA-templated transcription, initiation protein domain specific binding macromolecular complex negative regulation of megakaryocyte differentiation protein heterodimerization activity protein heterotetramerization uc007puo.1 uc007puo.2 uc007puo.3 uc007puo.4 
ENSMUST00000102968.3 H4c4 ENSMUST00000102968.3 H4 clustered histone 4 (from RefSeq NM_175654.3) A0AUM5 A4FUP8 A4QMY0 ENSMUST00000102968.1 ENSMUST00000102968.2 H4-12 H4-53 H4_MOUSE H4c1 H4c11 H4c12 H4c14 H4c16 H4c2 H4c3 H4c6 H4c8 H4c9 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist1h4m Hist2h4 Hist2h4a Hist4h4 NM_175654 P02304 P02305 P62806 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 uc007puh.1 uc007puh.2 uc007puh.3 uc007puh.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: SRR7345562.4751544.1, SRR7345562.4403263.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3- H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). P62806; Q8CDM1: Atad2; NbExp=2; IntAct=EBI-299632, EBI-2944582; P62806; Q9EQQ9: Oga; NbExp=2; IntAct=EBI-299632, EBI-8321615; Nucleus Chromosome Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Sumoylated, which is associated with transcriptional repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H4 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly DNA-templated transcription, initiation protein domain specific binding macromolecular complex negative regulation of megakaryocyte differentiation protein heterodimerization activity protein heterotetramerization uc007puh.1 uc007puh.2 uc007puh.3 uc007puh.4 
ENSMUST00000102969.6 H2ac8 ENSMUST00000102969.6 H2A clustered histone 8 (from RefSeq NM_178187.4) C0HKE9 ENSMUST00000102969.1 ENSMUST00000102969.2 ENSMUST00000102969.3 ENSMUST00000102969.4 ENSMUST00000102969.5 H2A1P_MOUSE Hist1h2ap NM_178187 P10812 P22752 Q149U0 Q5SZZ2 uc007pud.1 uc007pud.2 uc007pud.3 uc007pud.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007pud.1 uc007pud.2 uc007pud.3 uc007pud.4 
ENSMUST00000102971.2 H4c6 ENSMUST00000102971.2 H4 clustered histone 6 (from RefSeq NM_175655.3) A0AUM5 A4FUP8 A4QMY0 ENSMUST00000102971.1 H4-12 H4-53 H4_MOUSE H4c1 H4c11 H4c12 H4c14 H4c16 H4c2 H4c3 H4c4 H4c8 H4c9 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist1h4m Hist2h4 Hist2h4a Hist4h4 NM_175655 P02304 P02305 P62806 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 uc007pua.1 uc007pua.2 uc007pua.3 uc007pua.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. ##Evidence-Data-START## Transcript is intronless :: SRR7652917.1288199.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3- H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). P62806; Q8CDM1: Atad2; NbExp=2; IntAct=EBI-299632, EBI-2944582; P62806; Q9EQQ9: Oga; NbExp=2; IntAct=EBI-299632, EBI-8321615; Nucleus Chromosome Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Sumoylated, which is associated with transcriptional repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H4 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly DNA-templated transcription, initiation protein domain specific binding macromolecular complex negative regulation of megakaryocyte differentiation protein heterodimerization activity protein heterotetramerization uc007pua.1 uc007pua.2 uc007pua.3 uc007pua.4 
ENSMUST00000102972.6 H4c8 ENSMUST00000102972.6 H4 clustered histone 8 (from RefSeq NM_153173.4) A0AUM5 A4FUP8 A4QMY0 ENSMUST00000102972.1 ENSMUST00000102972.2 ENSMUST00000102972.3 ENSMUST00000102972.4 ENSMUST00000102972.5 H4-12 H4-53 H4_MOUSE H4c1 H4c11 H4c12 H4c14 H4c16 H4c2 H4c3 H4c4 H4c6 H4c9 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist1h4m Hist2h4 Hist2h4a Hist4h4 NM_153173 P02304 P02305 P62806 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 uc007ptv.1 uc007ptv.2 uc007ptv.3 uc007ptv.4 uc007ptv.5 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3- H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). P62806; Q8CDM1: Atad2; NbExp=2; IntAct=EBI-299632, EBI-2944582; P62806; Q9EQQ9: Oga; NbExp=2; IntAct=EBI-299632, EBI-8321615; Nucleus Chromosome Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Sumoylated, which is associated with transcriptional repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H4 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly DNA-templated transcription, initiation protein domain specific binding macromolecular complex negative regulation of megakaryocyte differentiation protein heterodimerization activity protein heterotetramerization uc007ptv.1 uc007ptv.2 uc007ptv.3 uc007ptv.4 uc007ptv.5 
ENSMUST00000102973.4 Aco1 ENSMUST00000102973.4 aconitase 1, transcript variant 1 (from RefSeq NM_007386.3) ACOHC_MOUSE ENSMUST00000102973.1 ENSMUST00000102973.2 ENSMUST00000102973.3 Ireb1 Irebp NM_007386 P28271 Q3TQ15 Q99K54 uc008shd.1 uc008shd.2 uc008shd.3 This gene encodes a member of the aconitase/IPM isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Depending on iron levels in the cytosol, the encoded protein can function as either an aconitase enzyme or as an mRNA binding protein. When cellular iron levels are high, the encoded protein functions as an aconitase, an essential enzyme in the TCA cycle that catalyzes the conversion of citrate to isocitrate. When cellular iron levels are low, the encoded protein regulates iron uptake and utilization by binding to iron-responsive elements in the untranslated regions of mRNAs for genes involved in iron metabolism. Disruption of this gene is associated with pulmonary hypertension and polycythemia. [provided by RefSeq, Jan 2014]. Sequence Note: This sequence has been modified as follows: removed 28 bp suspected to be vector contamination from the 3' end. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.207336.1, AK163985.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## multifunctional gene product(s) :: PMID: 1946430 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Bifunctional iron sensor that switches between 2 activities depending on iron availability (By similarity). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1956798). Conversely, when cellular iron levels are high, binds a 4Fe- 4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis- aconitate. Reaction=citrate = D-threo-isocitrate; Xref=Rhea:RHEA:10336, ChEBI:CHEBI:15562, ChEBI:CHEBI:16947; EC=4.2.1.3; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster per subunit. ; Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210). Cytoplasm, cytosol Belongs to the aconitase/IPM isomerase family. RNA binding aconitate hydratase activity cytoplasm mitochondrion endoplasmic reticulum Golgi apparatus cytosol tricarboxylic acid cycle citrate metabolic process regulation of translation cellular iron ion homeostasis post-embryonic development response to iron(II) ion regulation of gene expression lyase activity iron-responsive element binding intracellular membrane-bounded organelle metal ion binding mRNA 5'-UTR binding intestinal absorption iron-sulfur cluster binding 3 iron, 4 sulfur cluster binding 4 iron, 4 sulfur cluster binding uc008shd.1 uc008shd.2 uc008shd.3 
ENSMUST00000102975.10 Mob3b ENSMUST00000102975.10 MOB kinase activator 3B (from RefSeq NM_178061.5) ENSMUST00000102975.1 ENSMUST00000102975.2 ENSMUST00000102975.3 ENSMUST00000102975.4 ENSMUST00000102975.5 ENSMUST00000102975.6 ENSMUST00000102975.7 ENSMUST00000102975.8 ENSMUST00000102975.9 MOB3B_MOUSE Mobkl2b NM_178061 Q3U2L2 Q8BU65 Q8VE04 uc008sgs.1 uc008sgs.2 uc008sgs.3 Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. molecular_function cellular_component regulation of hippo signaling metal ion binding uc008sgs.1 uc008sgs.2 uc008sgs.3 
ENSMUST00000102976.4 Gata3 ENSMUST00000102976.4 GATA binding protein 3, transcript variant 1 (from RefSeq NM_008091.4) ENSMUST00000102976.1 ENSMUST00000102976.2 ENSMUST00000102976.3 Gata3 NM_008091 Q3U0R5 Q3U0R5_MOUSE uc008ihf.1 uc008ihf.2 Nucleus negative regulation of transcription from RNA polymerase II promoter nuclear chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding type IV hypersensitivity kidney development transcription factor activity, sequence-specific DNA binding transcription coactivator activity nucleus nucleoplasm regulation of transcription, DNA-templated transcription factor binding zinc ion binding response to virus positive regulation of signal transduction response to gamma radiation positive regulation of endothelial cell migration negative regulation of mammary gland epithelial cell proliferation cellular response to interferon-alpha response to drug sequence-specific DNA binding ear development response to estrogen transcription regulatory region DNA binding response to ethanol positive regulation of T cell differentiation negative regulation of fat cell differentiation negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding negative regulation of inflammatory response positive regulation of protein kinase B signaling mesenchymal to epithelial transition E-box binding cellular response to interleukin-4 cellular response to tumor necrosis factor HMG box domain binding lymphocyte migration cochlea development negative regulation of cell motility negative regulation of endothelial cell apoptotic process positive regulation of thyroid hormone generation positive regulation of interleukin-5 secretion positive regulation of interleukin-13 secretion positive regulation of transcription regulatory region DNA binding regulation of cellular response to X-ray uc008ihf.1 uc008ihf.2 
ENSMUST00000102977.4 H4c9 ENSMUST00000102977.4 H4 clustered histone 9 (from RefSeq NM_175656.3) A0AUM5 A4FUP8 A4QMY0 ENSMUST00000102977.1 ENSMUST00000102977.2 ENSMUST00000102977.3 H4-12 H4-53 H4_MOUSE H4c1 H4c11 H4c12 H4c14 H4c16 H4c2 H4c3 H4c4 H4c6 H4c8 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist1h4m Hist2h4 Hist2h4a Hist4h4 NM_175656 P02304 P02305 P62806 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 uc007psc.1 uc007psc.2 uc007psc.3 uc007psc.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BY227096.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3- H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). P62806; Q8CDM1: Atad2; NbExp=2; IntAct=EBI-299632, EBI-2944582; P62806; Q9EQQ9: Oga; NbExp=2; IntAct=EBI-299632, EBI-8321615; Nucleus Chromosome Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Sumoylated, which is associated with transcriptional repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H4 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly DNA-templated transcription, initiation protein domain specific binding macromolecular complex negative regulation of megakaryocyte differentiation protein heterodimerization activity protein heterotetramerization uc007psc.1 uc007psc.2 uc007psc.3 uc007psc.4 
ENSMUST00000102978.8 Zfp184 ENSMUST00000102978.8 May be involved in transcriptional regulation. (from UniProt Q7TSH9) AK036164 ENSMUST00000102978.1 ENSMUST00000102978.2 ENSMUST00000102978.3 ENSMUST00000102978.4 ENSMUST00000102978.5 ENSMUST00000102978.6 ENSMUST00000102978.7 Q7TSH9 ZN184_MOUSE uc288lgd.1 uc288lgd.2 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc288lgd.1 uc288lgd.2 
ENSMUST00000102979.2 H4c18 ENSMUST00000102979.2 H4 clustered histone 18 (from RefSeq NM_175657.3) A0AUM5 A4FUP8 A4QMY0 ENSMUST00000102979.1 H4-12 H4-53 H4_MOUSE H4c1 H4c11 H4c12 H4c14 H4c16 H4c2 H4c3 H4c4 H4c6 H4c8 H4c9 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist1h4m Hist2h4 Hist2h4a Hist4h4 NM_175657 P02304 P02305 P62806 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 uc007prs.1 uc007prs.2 uc007prs.3 uc007prs.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Sep 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: AV472770.1, CJ090441.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3- H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). P62806; Q8CDM1: Atad2; NbExp=2; IntAct=EBI-299632, EBI-2944582; P62806; Q9EQQ9: Oga; NbExp=2; IntAct=EBI-299632, EBI-8321615; Nucleus Chromosome Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Sumoylated, which is associated with transcriptional repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H4 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly DNA-templated transcription, initiation protein domain specific binding macromolecular complex negative regulation of megakaryocyte differentiation protein heterodimerization activity protein heterotetramerization uc007prs.1 uc007prs.2 uc007prs.3 uc007prs.4 
ENSMUST00000102980.11 Akr1b1 ENSMUST00000102980.11 aldo-keto reductase family 1 member B (from RefSeq NM_009658.3) Akr1b1 Akr1b3 ENSMUST00000102980.1 ENSMUST00000102980.10 ENSMUST00000102980.2 ENSMUST00000102980.3 ENSMUST00000102980.4 ENSMUST00000102980.5 ENSMUST00000102980.6 ENSMUST00000102980.7 ENSMUST00000102980.8 ENSMUST00000102980.9 NM_009658 Q3UDY1 Q3UDY1_MOUSE uc009bgy.1 uc009bgy.2 uc009bgy.3 uc009bgy.4 Reaction=(E)-hex-2-en-1-ol + NADP(+) = (E)-hex-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:58424, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:141205; Evidence=; Reaction=(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + H(+) + NADPH; Xref=Rhea:RHEA:58428, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:82334, ChEBI:CHEBI:142625; Evidence=; Reaction=1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3- phosphocholine + NADP(+); Xref=Rhea:RHEA:58512, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:77890, ChEBI:CHEBI:142747; Evidence=; Reaction=1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3- phosphoethanolamine + H(+) + NADPH = 1-hexadecanoyl-2-(5- hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+); Xref=Rhea:RHEA:58756, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142750, ChEBI:CHEBI:142751; Evidence=; Reaction=1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3- phosphocholine + NADP(+); Xref=Rhea:RHEA:58752, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:134601, ChEBI:CHEBI:142748; Evidence=; Reaction=1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3- phosphocholine + NADP(+); Xref=Rhea:RHEA:58592, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61042, ChEBI:CHEBI:142749; Evidence=; Reaction=13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH; Xref=Rhea:RHEA:54920, ChEBI:CHEBI:15378, ChEBI:CHEBI:45479, ChEBI:CHEBI:45487, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Reaction=9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH; Xref=Rhea:RHEA:54916, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78272, ChEBI:CHEBI:78273; Evidence=; Reaction=NADP(+) + prenol = 3-methyl-2-butenal + H(+) + NADPH; Xref=Rhea:RHEA:58420, ChEBI:CHEBI:15378, ChEBI:CHEBI:15825, ChEBI:CHEBI:16019, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Reaction=NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin H2; Xref=Rhea:RHEA:45312, ChEBI:CHEBI:15378, ChEBI:CHEBI:57404, ChEBI:CHEBI:57405, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Reaction=a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH; Xref=Rhea:RHEA:58336, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142593, ChEBI:CHEBI:142606; Evidence=; Reaction=all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH; Xref=Rhea:RHEA:25033, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.300; Evidence=; Reaction=an alditol + NADP(+) = an aldose + H(+) + NADPH; Xref=Rhea:RHEA:12789, Rhea:RHEA-COMP:9554, Rhea:RHEA-COMP:9555, ChEBI:CHEBI:15378, ChEBI:CHEBI:15693, ChEBI:CHEBI:17522, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.21; Evidence=; Monomer. Cytoplasm Belongs to the aldo/keto reductase family. retinoid metabolic process retinal dehydrogenase activity tissue homeostasis alditol:NADP+ 1-oxidoreductase activity extracellular space nucleoplasm cytosol monosaccharide metabolic process sorbitol biosynthetic process response to water deprivation response to organic substance oxidoreductase activity naphthalene metabolic process stress-activated protein kinase signaling cascade cell projection cytoplasm paranodal junction norepinephrine metabolic process mast cell granule Schmidt-Lanterman incisure glyceraldehyde oxidoreductase activity daunorubicin metabolic process doxorubicin metabolic process positive regulation of JAK-STAT cascade perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation oxidation-reduction process maternal process involved in female pregnancy cellular hyperosmotic salinity response inner medullary collecting duct development response to thyroid hormone cellular response to methylglyoxal Schwann cell microvillus cellular response to peptide uc009bgy.1 uc009bgy.2 uc009bgy.3 uc009bgy.4 
ENSMUST00000102981.10 Sec61a2 ENSMUST00000102981.10 SEC61 translocon subunit alpha 2, transcript variant 13 (from RefSeq NR_185337.1) ENSMUST00000102981.1 ENSMUST00000102981.2 ENSMUST00000102981.3 ENSMUST00000102981.4 ENSMUST00000102981.5 ENSMUST00000102981.6 ENSMUST00000102981.7 ENSMUST00000102981.8 ENSMUST00000102981.9 NR_185337 Q9JLR1 S61A2_MOUSE uc008ifx.1 uc008ifx.2 uc008ifx.3 Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the SecY/SEC61-alpha family. signal sequence binding endoplasmic reticulum Sec61 translocon complex endoplasmic reticulum membrane SRP-dependent cotranslational protein targeting to membrane, translocation posttranslational protein targeting to membrane protein transmembrane transporter activity protein transport membrane integral component of membrane ribosome binding uc008ifx.1 uc008ifx.2 uc008ifx.3 
ENSMUST00000102982.2 H2bc22 ENSMUST00000102982.2 H2B clustered histone 22, transcript variant 2 (from RefSeq NM_001290466.1) ENSMUST00000102982.1 H2B1P_MOUSE Hist1h2bp NM_001290466 Q64477 Q6P8V8 Q8CGP2 uc056ytc.1 uc056ytc.2 uc056ytc.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CGP2-1; Sequence=Displayed; Name=2; IsoId=Q8CGP2-2; Sequence=VSP_019618; Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. The human orthologous protein seems not to exist. Belongs to the histone H2B family. nucleosome DNA binding nucleus nucleoplasm chromosome cytosol nucleosome assembly protein heterodimerization activity uc056ytc.1 uc056ytc.2 uc056ytc.3 
ENSMUST00000102983.2 H4c12 ENSMUST00000102983.2 H4 clustered histone 12 (from RefSeq NM_178211.2) A0AUM5 A4FUP8 A4QMY0 ENSMUST00000102983.1 H4-12 H4-53 H4_MOUSE H4c1 H4c11 H4c14 H4c16 H4c2 H4c3 H4c4 H4c6 H4c8 H4c9 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist1h4m Hist2h4 Hist2h4a Hist4h4 NM_178211 P02304 P02305 P62806 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 uc007prf.1 uc007prf.2 uc007prf.3 uc007prf.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC117010.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3- H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). P62806; Q8CDM1: Atad2; NbExp=2; IntAct=EBI-299632, EBI-2944582; P62806; Q9EQQ9: Oga; NbExp=2; IntAct=EBI-299632, EBI-8321615; Nucleus Chromosome Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Sumoylated, which is associated with transcriptional repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H4 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly DNA-templated transcription, initiation protein domain specific binding macromolecular complex negative regulation of megakaryocyte differentiation protein heterodimerization activity protein heterotetramerization uc007prf.1 uc007prf.2 uc007prf.3 uc007prf.4 
ENSMUST00000102985.8 Mcm10 ENSMUST00000102985.8 minichromosome maintenance 10 replication initiation factor, transcript variant 1 (from RefSeq NM_001305259.1) ENSMUST00000102985.1 ENSMUST00000102985.2 ENSMUST00000102985.3 ENSMUST00000102985.4 ENSMUST00000102985.5 ENSMUST00000102985.6 ENSMUST00000102985.7 MCM10_MOUSE NM_001305259 Q0VBD2 Q505F3 Q8BMJ1 Q8BYA7 uc056zjd.1 uc056zjd.2 uc056zjd.3 Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (By similarity). Self-associates (By similarity). Interacts with ORC2. May interact with MCM2 and MCM6. Interacts with the DNA polymerase alpha subunit POLA1. Interacts with RECQL4; this interaction regulates RECQL4 unwinding activity. Interacts with WDHD1 (By similarity). Nucleus Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase (By similarity). Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain. The N-terminal domain mediates homodimerization. Belongs to the MCM10 family. DNA binding DNA replication origin binding double-stranded DNA binding single-stranded DNA binding nucleus nucleolus DNA replication DNA replication initiation cellular response to DNA damage stimulus cell proliferation enzyme binding replication fork protection complex identical protein binding metal ion binding uc056zjd.1 uc056zjd.2 uc056zjd.3 
ENSMUST00000102989.10 Nmt2 ENSMUST00000102989.10 N-myristoyltransferase 2, transcript variant 4 (from RefSeq NM_001290370.1) A2AJH3 A2AJH3_MOUSE ENSMUST00000102989.1 ENSMUST00000102989.2 ENSMUST00000102989.3 ENSMUST00000102989.4 ENSMUST00000102989.5 ENSMUST00000102989.6 ENSMUST00000102989.7 ENSMUST00000102989.8 ENSMUST00000102989.9 NM_001290370 Nmt2 uc056ziz.1 uc056ziz.2 uc056ziz.3 Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Reaction=N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]; Xref=Rhea:RHEA:70671, Rhea:RHEA-COMP:17947, Rhea:RHEA-COMP:17948, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:189855, ChEBI:CHEBI:189856; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70672; Evidence=; Reaction=N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]; Xref=Rhea:RHEA:15521, Rhea:RHEA- COMP:12666, Rhea:RHEA-COMP:12667, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:64723, ChEBI:CHEBI:133050; EC=2.3.1.97; Evidence= Belongs to the NMT family. glycylpeptide N-tetradecanoyltransferase activity N-terminal protein myristoylation transferase activity transferase activity, transferring acyl groups uc056ziz.1 uc056ziz.2 uc056ziz.3 
ENSMUST00000102993.10 Ube2h ENSMUST00000102993.10 ubiquitin-conjugating enzyme E2H, transcript variant 1 (from RefSeq NM_009459.3) ENSMUST00000102993.1 ENSMUST00000102993.2 ENSMUST00000102993.3 ENSMUST00000102993.4 ENSMUST00000102993.5 ENSMUST00000102993.6 ENSMUST00000102993.7 ENSMUST00000102993.8 ENSMUST00000102993.9 NM_009459 Q3V2N4 Q3V2N4_MOUSE Ube2h uc009bez.1 uc009bez.2 uc009bez.3 uc009bez.4 uc009bez.5 Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding ubiquitin-protein transferase activity ATP binding transferase activity protein K48-linked ubiquitination protein K11-linked ubiquitination uc009bez.1 uc009bez.2 uc009bez.3 uc009bez.4 uc009bez.5 
ENSMUST00000102994.10 Ufl1 ENSMUST00000102994.10 UFM1 specific ligase 1, transcript variant 1 (from RefSeq NM_026194.5) A2RSP7 B1AXU5 B1AXU6 ENSMUST00000102994.1 ENSMUST00000102994.2 ENSMUST00000102994.3 ENSMUST00000102994.4 ENSMUST00000102994.5 ENSMUST00000102994.6 ENSMUST00000102994.7 ENSMUST00000102994.8 ENSMUST00000102994.9 Kiaa0776 Maxer NM_026194 Q3V145 Q6ZQ50 Q8BT70 Q8C484 Q8CCJ3 Q9D8I8 Rcad UFL1_MOUSE Ufl1 uc008seh.1 uc008seh.2 uc008seh.3 uc008seh.4 E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (By similarity). In response to endoplasmic reticulum stress, recruited to the endoplasmic reticulum membrane by DDRGK1, and mediates ufmylation of proteins such as RPN1 and RPL26/uL24, thereby promoting reticulophagy of endoplasmic reticulum sheets (By similarity). Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) via ERN1/IRE1-alpha (By similarity). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (PubMed:25952549, PubMed:29461087, PubMed:30701081). Regulates inflammation in response to endoplasmic reticulum stress by promoting reticulophagy, leading to inhibit the activity of the NF-kappa-B transcription factor (By similarity). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is a collateral effect or is required for ufmylation (By similarity). Catalyzes ufmylation of various subunits of the ribosomal complex or associated components, such as RPS3/uS3, RPS20/uS10, RPL10/uL16, RPL26/uL24 and EIF6 (PubMed:28575669). Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (By similarity). Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 (By similarity). Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (By similarity). Required for hematopoietic stem cell function and hematopoiesis (PubMed:25952549). Required for cardiac homeostasis (PubMed:30354401). Interacts with DDRGK1 (via PCI domain) (By similarity). Interacts with UFC1 (By similarity). Interacts with RELA (By similarity). Interacts with TRIP4 (By similarity). Interacts with CDK5RAP3; the interaction is direct (PubMed:21494687, PubMed:30635284). Interacts with NBN; promoting recruitment to double-strand breaks following DNA damage (By similarity). Endoplasmic reticulum membrane Cytoplasm, cytosol Nucleus Chromosome Note=Recruited to double- strand breaks by the MRE11-RAD50-NBN (MRN) complex following DNA damage. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CCJ3-3; Sequence=Displayed; Name=2; IsoId=Q8CCJ3-1; Sequence=VSP_014250, VSP_014251; Name=3; IsoId=Q8CCJ3-2; Sequence=VSP_014249; Ubiquitously expressed with higher expression in pancreatic islets and other secretory tissues (PubMed:20228063, PubMed:21494687). In the embryonic brain at 17 dpc, detected in Sox2- positive neural stem cells and in Slc1a3/GLAST-positive radial glia (PubMed:20531390). In perinatal brain, highly expressed in Slc1a3- positive Bergmann glia of the cerebellum (PubMed:20531390). Continues to be expressed in Bergmann glia of adult brain at 16 weeks (PubMed:20531390). Expressed in adult heart (PubMed:30354401). Highly expressed in the intestinal exocrine cells (PubMed:30701081). Up-regulated in hypertrophic hearts (at protein level). Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects both proteins against ubiquitination and degradation via the proteasome. Phosphorylated at Ser-462 by ATM, enhancing protein ligase activity and promoting ATM activation in a positive feedback loop. Embryonic lethality caused by impaired erythroid development (PubMed:25952549). Conditional deletion in adult mice results in severe anemia and cytopenia (PubMed:25952549). Cells show elevated endoplasmic reticulum stress and unfolded protein response in bone marrow cells and impaired autophagic degradation (PubMed:25952549). Conditional knockout in cardiomyocytes causes age- dependent cardiomyopathy and heart failure, characterized by elevated cardiac fetal gene expression, increased fibrosis, and impaired cardiac contractility (PubMed:30354401). When challenged with pressure overload, cardiac-specific knockout mice display greater hypertrophy, exacerbated fibrosis, and worsened cardiac contractility compared to wild-type mice counterparts (PubMed:30354401). Conditional knockout in adults causes a significant loss of both Paneth and goblet cells in intestine, which in turn results in dysbiotic microbiota and increased susceptibility to experimentally induced colitis (PubMed:30701081). Belongs to the UFL1 family. Sequence=BAC98021.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol positive regulation of cell proliferation regulation of gene expression transferase activity negative regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity positive regulation of protein binding regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein localization macromolecular complex regulation of intracellular estrogen receptor signaling pathway response to endoplasmic reticulum stress neuron projection negative regulation of apoptotic process positive regulation of glial cell proliferation UFM1 transferase activity protein ufmylation response to L-glutamate protein K69-linked ufmylation uc008seh.1 uc008seh.2 uc008seh.3 uc008seh.4 
ENSMUST00000102996.4 Cfap20dc ENSMUST00000102996.4 CFAP20 domain containing (from RefSeq NM_028934.3) CF20D_MOUSE Cfap20dc E9QK14 ENSMUST00000102996.1 ENSMUST00000102996.2 ENSMUST00000102996.3 NM_028934 Q6P2K3 uc007sfe.1 uc007sfe.2 uc007sfe.3 uc007sfe.4 molecular_function cellular_component biological_process uc007sfe.1 uc007sfe.2 uc007sfe.3 uc007sfe.4 
ENSMUST00000102997.8 Ccnc ENSMUST00000102997.8 cyclin C, transcript variant 1 (from RefSeq NM_016746.5) CCNC_MOUSE ENSMUST00000102997.1 ENSMUST00000102997.2 ENSMUST00000102997.3 ENSMUST00000102997.4 ENSMUST00000102997.5 ENSMUST00000102997.6 ENSMUST00000102997.7 NM_016746 Q0P542 Q5XKQ9 Q62447 Q9WUZ4 uc008scu.1 uc008scu.2 uc008scu.3 uc008scu.4 uc008scu.5 Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II (By similarity). Nucleus Belongs to the cyclin family. Cyclin C subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity ubiquitin ligase complex nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter cyclin-dependent protein serine/threonine kinase regulator activity protein ubiquitination mediator complex positive regulation of transcription from RNA polymerase II promoter negative regulation of triglyceride metabolic process ubiquitin protein ligase activity uc008scu.1 uc008scu.2 uc008scu.3 uc008scu.4 uc008scu.5 
ENSMUST00000102999.2 Cngb3 ENSMUST00000102999.2 cyclic nucleotide gated channel beta 3 (from RefSeq NM_013927.2) CNGB3_MOUSE Cng6 ENSMUST00000102999.1 NM_013927 Q9JJZ9 uc008sbx.1 uc008sbx.2 Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Tetramer formed of three CNGA3 and one CNGB3 modulatory subunits. Membrane; Multi-pass membrane protein. Small subset of retinal photoreceptor cells and testis. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB3 subfamily. nucleotide binding photoreceptor outer segment intracellular cAMP activated cation channel activity intracellular cGMP activated cation channel activity protein binding plasma membrane ion transport cation transport visual perception membrane integral component of membrane cGMP binding response to stimulus cation transmembrane transport transmembrane transporter complex uc008sbx.1 uc008sbx.2 
ENSMUST00000103000.9 Ssxb2 ENSMUST00000103000.9 SSX member B2, transcript variant 2 (from RefSeq NM_001134226.1) ENSMUST00000103000.1 ENSMUST00000103000.2 ENSMUST00000103000.3 ENSMUST00000103000.4 ENSMUST00000103000.5 ENSMUST00000103000.6 ENSMUST00000103000.7 ENSMUST00000103000.8 NM_001134226 Q80ZT4 Q80ZT4_MOUSE Ssxb2 uc009spa.1 uc009spa.2 uc009spa.3 uc009spa.4 Belongs to the SSX family. nucleic acid binding nucleus regulation of transcription, DNA-templated uc009spa.1 uc009spa.2 uc009spa.3 uc009spa.4 
ENSMUST00000103001.4 Ssxb13 ENSMUST00000103001.4 SSX member B13 (from RefSeq NM_199063.2) ENSMUST00000103001.1 ENSMUST00000103001.2 ENSMUST00000103001.3 NM_199063 Q6XAS3 Q6XAS3_MOUSE Ssx9 Ssxb13 Ssxb3 Ssxb4 uc009spf.1 uc009spf.2 uc009spf.3 uc009spf.4 Belongs to the SSX family. nucleic acid binding nucleus regulation of transcription, DNA-templated uc009spf.1 uc009spf.2 uc009spf.3 uc009spf.4 
ENSMUST00000103003.4 Ssxb10 ENSMUST00000103003.4 SSX member B10 (from RefSeq NM_199064.1) ENSMUST00000103003.1 ENSMUST00000103003.2 ENSMUST00000103003.3 NM_199064 Q6XAR7 Q6XAR7_MOUSE Ssxb10 uc009sou.1 uc009sou.2 uc009sou.3 Belongs to the SSX family. nucleic acid binding nucleus regulation of transcription, DNA-templated uc009sou.1 uc009sou.2 uc009sou.3 
ENSMUST00000103005.10 Shroom4 ENSMUST00000103005.10 shroom family member 4, transcript variant 2 (from RefSeq NM_001313764.1) A2ADV9 B2RX74 ENSMUST00000103005.1 ENSMUST00000103005.2 ENSMUST00000103005.3 ENSMUST00000103005.4 ENSMUST00000103005.5 ENSMUST00000103005.6 ENSMUST00000103005.7 ENSMUST00000103005.8 ENSMUST00000103005.9 Kiaa1202 NM_001313764 Q1W617 Q69ZN9 SHRM4_MOUSE uc009sky.1 uc009sky.2 uc009sky.3 uc009sky.4 Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II. Interacts directly with F-actin. Cytoplasm, cytoskeleton Note=Shows partial colocalization with the cytoplasmic pool of F-actin. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q1W617-1; Sequence=Displayed; Name=2; IsoId=Q1W617-2; Sequence=VSP_025291; Detected in most adult tissues examined. Expressed in brain, lung, heart, liver, kidney, muscle and ovary. Expressed throughout the brain, with high expression in the brain stem and cerebellum and weaker expression in the hypothalamus, the hippocampus and the olfactory bulb. Expressed in wide range of cell types during developpment, including vascular endothelium and the polarized epithelium of the neural tube and kidney. Slight expression at 8.5 dpc, increasing till 11.5 dpc and remaining continuous thereafter, suggesting regulated expression during development. Belongs to the shroom family. Sequence=BAD32407.1; Type=Erroneous initiation; Evidence=; actin binding cytoplasm cytoskeleton actin filament adherens junction actin filament organization multicellular organism development brain development cytoplasmic side of plasma membrane basal plasma membrane apical plasma membrane actin cytoskeleton organization cortical actin cytoskeleton apical junction complex myosin II binding cognition actin filament binding stress fiber actin cytoskeleton cell morphogenesis uc009sky.1 uc009sky.2 uc009sky.3 uc009sky.4 
ENSMUST00000103006.4 Nudt10 ENSMUST00000103006.4 nudix hydrolase 10 (from RefSeq NM_001031664.1) Dipp3b ENSMUST00000103006.1 ENSMUST00000103006.2 ENSMUST00000103006.3 MNCb-1696 NM_001031664 NUD11_MOUSE Nudt11 P0C028 Q8BKF4 Q9JJD3 uc009skw.1 uc009skw.2 uc009skw.3 uc009skw.4 Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear. Reaction=diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.; EC=3.6.1.52; Evidence=; Reaction=H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'- pentaphosphate + AMP + 2 H(+); Xref=Rhea:RHEA:32047, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:63740, ChEBI:CHEBI:63813, ChEBI:CHEBI:456215; EC=3.6.1.60; Evidence=; Reaction=H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = adenosine 5'-tetraphosphate + AMP + 2 H(+); Xref=Rhea:RHEA:32051, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58450, ChEBI:CHEBI:62041, ChEBI:CHEBI:456215; EC=3.6.1.60; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 3 Mg(2+) or Mn(2+) ions per subunit. Mn(2+) may be the true cofactor in vivo. ; Cytoplasm Predominantly expressed in brain and is weakly or not expressed in other tissues. Nudt10 and Nudt11 code for identical proteins, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the 2 proteins. Belongs to the Nudix hydrolase family. DIPP subfamily. endopolyphosphatase activity nucleus cytoplasm cytosol diphosphoinositol-polyphosphate diphosphatase activity hydrolase activity bis(5'-adenosyl)-hexaphosphatase activity bis(5'-adenosyl)-pentaphosphatase activity metal ion binding m7G(5')pppN diphosphatase activity inositol diphosphate tetrakisphosphate diphosphatase activity inositol diphosphate pentakisphosphate diphosphatase activity diphosphoinositol polyphosphate metabolic process diadenosine pentaphosphate catabolic process diadenosine hexaphosphate catabolic process adenosine 5'-(hexahydrogen pentaphosphate) catabolic process uc009skw.1 uc009skw.2 uc009skw.3 uc009skw.4 
ENSMUST00000103007.4 Nudt11 ENSMUST00000103007.4 nudix hydrolase 11 (from RefSeq NM_021431.2) Dipp3b ENSMUST00000103007.1 ENSMUST00000103007.2 ENSMUST00000103007.3 MNCb-1696 NM_021431 NUD11_MOUSE Nudt11 P0C028 Q8BKF4 Q9JJD3 uc009sku.1 uc009sku.2 uc009sku.3 Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear. Reaction=diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.; EC=3.6.1.52; Evidence=; Reaction=H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'- pentaphosphate + AMP + 2 H(+); Xref=Rhea:RHEA:32047, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:63740, ChEBI:CHEBI:63813, ChEBI:CHEBI:456215; EC=3.6.1.60; Evidence=; Reaction=H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = adenosine 5'-tetraphosphate + AMP + 2 H(+); Xref=Rhea:RHEA:32051, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58450, ChEBI:CHEBI:62041, ChEBI:CHEBI:456215; EC=3.6.1.60; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 3 Mg(2+) or Mn(2+) ions per subunit. Mn(2+) may be the true cofactor in vivo. ; Cytoplasm Predominantly expressed in brain and is weakly or not expressed in other tissues. Nudt10 and Nudt11 code for identical proteins, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the 2 proteins. Belongs to the Nudix hydrolase family. DIPP subfamily. endopolyphosphatase activity nucleus cytoplasm cytosol diphosphoinositol-polyphosphate diphosphatase activity hydrolase activity bis(5'-adenosyl)-hexaphosphatase activity bis(5'-adenosyl)-pentaphosphatase activity metal ion binding m7G(5')pppN diphosphatase activity inositol diphosphate tetrakisphosphate diphosphatase activity inositol diphosphate pentakisphosphate diphosphatase activity diphosphoinositol polyphosphate metabolic process diadenosine pentaphosphate catabolic process diadenosine hexaphosphate catabolic process adenosine 5'-(hexahydrogen pentaphosphate) catabolic process uc009sku.1 uc009sku.2 uc009sku.3 
ENSMUST00000103008.12 Sdcbp ENSMUST00000103008.12 syndecan binding protein, transcript variant 2 (from RefSeq NM_016807.3) ENSMUST00000103008.1 ENSMUST00000103008.10 ENSMUST00000103008.11 ENSMUST00000103008.2 ENSMUST00000103008.3 ENSMUST00000103008.4 ENSMUST00000103008.5 ENSMUST00000103008.6 ENSMUST00000103008.7 ENSMUST00000103008.8 ENSMUST00000103008.9 NM_016807 Q3TMX0 Q3TMX0_MOUSE Sdcbp uc008rxm.1 uc008rxm.2 uc008rxm.3 chemical synaptic transmission membrane integral component of membrane actin cytoskeleton organization intracellular signal transduction uc008rxm.1 uc008rxm.2 uc008rxm.3 
ENSMUST00000103012.10 Mup1 ENSMUST00000103012.10 major urinary protein 1, transcript variant 2 (from RefSeq NM_031188.2) A2CEL1 A2CEL1_MOUSE ENSMUST00000103012.1 ENSMUST00000103012.2 ENSMUST00000103012.3 ENSMUST00000103012.4 ENSMUST00000103012.5 ENSMUST00000103012.6 ENSMUST00000103012.7 ENSMUST00000103012.8 ENSMUST00000103012.9 Mup1 Mup7 NM_031188 uc008taq.1 uc008taq.2 uc008taq.3 uc008taq.4 Secreted Belongs to the calycin superfamily. Lipocalin family. small molecule binding uc008taq.1 uc008taq.2 uc008taq.3 uc008taq.4 
ENSMUST00000103013.10 Tbcd ENSMUST00000103013.10 tubulin-specific chaperone d (from RefSeq NM_029878.4) ENSMUST00000103013.1 ENSMUST00000103013.2 ENSMUST00000103013.3 ENSMUST00000103013.4 ENSMUST00000103013.5 ENSMUST00000103013.6 ENSMUST00000103013.7 ENSMUST00000103013.8 ENSMUST00000103013.9 NM_029878 Q8BYA0 TBCD_MOUSE uc007mvy.1 uc007mvy.2 uc007mvy.3 uc007mvy.4 Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with PPP2CB (By similarity). Part of a supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Interacts with ARL2; interaction is enhanced with the GDP-bound form of ARL2. Does not interact with ARL3, ARL4A and ARL4D. Interacts with beta tubulin. Interacts with TBCE (By similarity). Cell junction, tight junction Lateral cell membrane Cytoplasm Cell junction, adherens junction Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localized in cell-cell contacts. Belongs to the TBCD family. microtubule cytoskeleton organization mitotic cell cycle GTPase activator activity cytoplasm centrosome microtubule organizing center cytoskeleton plasma membrane adherens junction bicellular tight junction protein folding tubulin complex assembly post-chaperonin tubulin folding pathway negative regulation of cell-substrate adhesion membrane lateral plasma membrane cell junction negative regulation of microtubule polymerization adherens junction assembly positive regulation of GTPase activity beta-tubulin binding cell morphogenesis involved in neuron differentiation bicellular tight junction assembly uc007mvy.1 uc007mvy.2 uc007mvy.3 uc007mvy.4 
ENSMUST00000103015.4 Narf ENSMUST00000103015.4 nuclear prelamin A recognition factor (from RefSeq NM_026272.3) ENSMUST00000103015.1 ENSMUST00000103015.2 ENSMUST00000103015.3 NARF_MOUSE NM_026272 Q8BVW9 Q9CYQ7 uc007mvq.1 uc007mvq.2 uc007mvq.3 uc007mvq.4 Interacts with LMNA and binds to the farnesylated C-terminal domain. Nucleus Belongs to the NARF family. lamin binding nucleus lamin filament nucleolus biological_process nuclear lumen uc007mvq.1 uc007mvq.2 uc007mvq.3 uc007mvq.4 
ENSMUST00000103018.11 Slc38a10 ENSMUST00000103018.11 solute carrier family 38, member 10, transcript variant 1 (from RefSeq NM_024249.5) A2AMZ5 ENSMUST00000103018.1 ENSMUST00000103018.10 ENSMUST00000103018.2 ENSMUST00000103018.3 ENSMUST00000103018.4 ENSMUST00000103018.5 ENSMUST00000103018.6 ENSMUST00000103018.7 ENSMUST00000103018.8 ENSMUST00000103018.9 NM_024249 Q3TVW4 Q5I012 Q641M1 Q80ZZ4 Q8C1Y0 Q8CCR5 Q9D8J3 S38AA_MOUSE Slc38a10 uc007mrv.1 uc007mrv.2 uc007mrv.3 uc007mrv.4 Facilitates bidirectional transport of amino acids. May act as a glutamate sensor that regulates glutamate-glutamine cycle and mTOR signaling in the brain. The transport mechanism remains to be elucidated. Reaction=L-glutamate(out) = L-glutamate(in); Xref=Rhea:RHEA:66336, ChEBI:CHEBI:29985; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66337; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:66338; Evidence=; Reaction=L-glutamine(out) = L-glutamine(in); Xref=Rhea:RHEA:73419, ChEBI:CHEBI:58359; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73420; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:73421; Evidence=; Reaction=L-alanine(in) = L-alanine(out); Xref=Rhea:RHEA:70719, ChEBI:CHEBI:57972; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70720; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70721; Evidence=; Reaction=L-serine(in) = L-serine(out); Xref=Rhea:RHEA:35031, ChEBI:CHEBI:33384; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35032; Evidence=; Reaction=L-leucine(in) = L-leucine(out); Xref=Rhea:RHEA:73011, ChEBI:CHEBI:57427; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:73013; Evidence=; Membrane ; Multi- pass membrane protein Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q5I012-1; Sequence=Displayed; Name=2; IsoId=Q5I012-2; Sequence=VSP_031333; Name=3; IsoId=Q5I012-3; Sequence=VSP_031332; Name=4; IsoId=Q5I012-4; Sequence=VSP_031332, VSP_031333; Name=5; IsoId=Q5I012-5; Sequence=VSP_031329, VSP_031330; Name=6; IsoId=Q5I012-6; Sequence=VSP_031328, VSP_031331; Expressed in neurons, astrocytes and epithelial cells scattered throughout the central nervous system structures including striatum, ependyma, cerebral cortex, hippocampus, hypothalamus, thalamus, pons, and cerebellum (at protein level). Highly expressed in paraventricular hypothalamic nucleus, suprachiasmatic nucleus, anterior hypothalamic area central part, in lateral ventricule and in dorsal 3rd ventricule (at protein level). Expressed in choroid plexus epithelial cells (at protein level). Belongs to the amino acid/polyamine transporter 2 family. Sequence=AAH43299.1; Type=Erroneous initiation; Evidence=; amino acid transmembrane transport Golgi apparatus ion transport sodium ion transport amino acid transport amino acid transmembrane transporter activity membrane integral component of membrane bone development uc007mrv.1 uc007mrv.2 uc007mrv.3 uc007mrv.4 
ENSMUST00000103020.8 Aatk ENSMUST00000103020.8 apoptosis-associated tyrosine kinase, transcript variant 8 (from RefSeq NR_175298.1) Aatk B1AZF9 B1AZF9_MOUSE ENSMUST00000103020.1 ENSMUST00000103020.2 ENSMUST00000103020.3 ENSMUST00000103020.4 ENSMUST00000103020.5 ENSMUST00000103020.6 ENSMUST00000103020.7 NR_175298 uc007mrm.1 uc007mrm.2 uc007mrm.3 uc007mrm.4 uc007mrm.5 uc007mrm.6 protein kinase activity ATP binding protein phosphorylation kinase activity phosphorylation uc007mrm.1 uc007mrm.2 uc007mrm.3 uc007mrm.4 uc007mrm.5 uc007mrm.6 
ENSMUST00000103027.10 Mgat5b ENSMUST00000103027.10 mannoside acetylglucosaminyltransferase 5, isoenzyme B (from RefSeq NM_172948.3) ENSMUST00000103027.1 ENSMUST00000103027.2 ENSMUST00000103027.3 ENSMUST00000103027.4 ENSMUST00000103027.5 ENSMUST00000103027.6 ENSMUST00000103027.7 ENSMUST00000103027.8 ENSMUST00000103027.9 MGT5B_MOUSE NM_172948 Q765H6 Q8C7T8 uc033gbm.1 uc033gbm.2 uc033gbm.3 Glycosyltransferase that acts on alpha-linked mannose of N- glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6- linked mannose arms in the core structure of N-glycan (By similarity). Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan (PubMed:22715095). Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O- mannosyl glycan pathway. Reaction=N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man- (1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N- acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta- D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D- GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc- (1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:16921, Rhea:RHEA-COMP:14374, Rhea:RHEA-COMP:14377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:139507, ChEBI:CHEBI:139510; EC=2.4.1.155; Evidence=; Reaction=3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L- seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N- acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl- (1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP; Xref=Rhea:RHEA:56252, Rhea:RHEA-COMP:14438, Rhea:RHEA-COMP:14440, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:140080, ChEBI:CHEBI:140085; Evidence=; Reaction=3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L- threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D- glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP; Xref=Rhea:RHEA:56256, Rhea:RHEA-COMP:14439, Rhea:RHEA-COMP:14441, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:140083, ChEBI:CHEBI:140087; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q765H6-1; Sequence=Displayed; Name=2; IsoId=Q765H6-2; Sequence=VSP_025736, VSP_025737, VSP_025738; Present in brain (at protein level) (PubMed:16413118). Predominantly expressed in hippocampus, superficial layers of the brain cortex, striatum, nucleus accumbens, a subset of nuclei in the thalamus, inferior colliculus, brain stem and cerebellum (PubMed:16413118, PubMed:22715095). Brains from mutant mice display defective biosynthesis of O-mannosyl glycans (PubMed:22715095). Mutant mice that lack both Mgat5 and Mgat5b display no visible changes in brain anatomy, but their brains display defective biosynthesis of both O-mannosyl glycans and N-linked glycans (PubMed:22715095). Belongs to the glycosyltransferase 18 family. Golgi membrane Golgi apparatus protein glycosylation protein N-linked glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via serine alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity manganese ion binding metal ion binding uc033gbm.1 uc033gbm.2 uc033gbm.3 
ENSMUST00000103028.8 Rhbdf2 ENSMUST00000103028.8 rhomboid 5 homolog 2, transcript variant 1 (from RefSeq NM_172572.4) ENSMUST00000103028.1 ENSMUST00000103028.2 ENSMUST00000103028.3 ENSMUST00000103028.4 ENSMUST00000103028.5 ENSMUST00000103028.6 ENSMUST00000103028.7 Irhom2 NM_172572 Q3TBR9 Q80WQ6 Q8BJ70 Q8K2I7 RHDF2_MOUSE Rhbdl6 Rhor uc007mlt.1 uc007mlt.2 uc007mlt.3 uc007mlt.4 uc007mlt.5 uc007mlt.6 Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. Interacts with EGF (PubMed:21439629). Interacts (via cytoplasmic N-terminus) with FRMD8/iTAP; this interaction leads to mutual protein stabilization (PubMed:29897336). Interacts with ADAM17/TACE (By similarity). Q80WQ6; Q9Z0F8: Adam17; NbExp=6; IntAct=EBI-647271, EBI-7848498; Q80WQ6; P78536: ADAM17; Xeno; NbExp=2; IntAct=EBI-647271, EBI-78188; Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the peptidase S54 family. protein binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane proteolysis protein transport membrane integral component of membrane regulation of epidermal growth factor receptor signaling pathway regulation of protein secretion negative regulation of protein secretion serine-type endopeptidase activity uc007mlt.1 uc007mlt.2 uc007mlt.3 uc007mlt.4 uc007mlt.5 uc007mlt.6 
ENSMUST00000103031.8 Fbf1 ENSMUST00000103031.8 Fas binding factor 1, transcript variant 1 (from RefSeq NM_172571.3) A2A870 A2A871 B2RQ77 ENSMUST00000103031.1 ENSMUST00000103031.2 ENSMUST00000103031.3 ENSMUST00000103031.4 ENSMUST00000103031.5 ENSMUST00000103031.6 ENSMUST00000103031.7 FBF1_MOUSE NM_172571 Q8BSP0 Q99MZ9 uc288dqx.1 uc288dqx.2 Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis (By similarity). Interacts with PARD3 (By similarity). May interact with FAS cytoplasmic domain (By similarity). Interacts with TRAPPC14 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle pole Cell junction Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to the apical junction complex (AJC) in epithelial cells (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2A870-1; Sequence=Displayed; Name=2; IsoId=A2A870-2; Sequence=VSP_027324; Broadly expressed. spindle pole protein binding cytoplasm centrosome centriole cytoskeleton cell projection organization cell junction ciliary basal body apical junction complex apical junction assembly keratin filament cilium assembly establishment of epithelial cell polarity ciliary transition fiber uc288dqx.1 uc288dqx.2 
ENSMUST00000103032.11 Llgl2 ENSMUST00000103032.11 LLGL2 scribble cell polarity complex component, transcript variant 1 (from RefSeq NM_145438.2) B1ATB0 ENSMUST00000103032.1 ENSMUST00000103032.10 ENSMUST00000103032.2 ENSMUST00000103032.3 ENSMUST00000103032.4 ENSMUST00000103032.5 ENSMUST00000103032.6 ENSMUST00000103032.7 ENSMUST00000103032.8 ENSMUST00000103032.9 L2GL2_MOUSE Llglh2 NM_145438 Q3TJ91 Q6YP20 Q8K1X0 uc007mit.1 uc007mit.2 uc007mit.3 Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par- 6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity (By similarity). Interacts with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6. The complex is enhanced during mitosis. Interacts with DCAF1 (By similarity). Cytoplasm Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells (By similarity). Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced during cell polarization induced by calcium. Phosphorylation may occur during the cell-cell contact-induced cell polarization and may contribute to the segregation of LLGL2 from the PRKCI/aPKC and PARD6B/Par-6 complex (By similarity). Belongs to the WD repeat L(2)GL family. placenta development GTPase activator activity cytoplasm cytosol plasma membrane exocytosis cell cycle regulation of Notch signaling pathway post-embryonic development establishment or maintenance of polarity of embryonic epithelium Rab GTPase binding PDZ domain binding cortical actin cytoskeleton cortical actin cytoskeleton organization regulation of establishment or maintenance of cell polarity multicellular organism growth intracellular membrane-bounded organelle positive regulation of GTPase activity myosin II binding establishment of spindle orientation cell division branching involved in labyrinthine layer morphogenesis labyrinthine layer blood vessel development uc007mit.1 uc007mit.2 uc007mit.3 
ENSMUST00000103035.10 Kctd2 ENSMUST00000103035.10 potassium channel tetramerisation domain containing 2, transcript variant 2 (from RefSeq NR_175855.1) ENSMUST00000103035.1 ENSMUST00000103035.2 ENSMUST00000103035.3 ENSMUST00000103035.4 ENSMUST00000103035.5 ENSMUST00000103035.6 ENSMUST00000103035.7 ENSMUST00000103035.8 ENSMUST00000103035.9 Kctd2 NR_175855 Q4VBE7 Q4VBE7_MOUSE uc007mhn.1 uc007mhn.2 uc007mhn.3 uc007mhn.4 macromolecular complex binding protein homooligomerization uc007mhn.1 uc007mhn.2 uc007mhn.3 uc007mhn.4 
ENSMUST00000103037.5 Ush1g ENSMUST00000103037.5 USH1 protein network component sans (from RefSeq NM_176847.3) ENSMUST00000103037.1 ENSMUST00000103037.2 ENSMUST00000103037.3 ENSMUST00000103037.4 NM_176847 Q80T11 Q80UG0 Sans USH1G_MOUSE uc007mhc.1 uc007mhc.2 uc007mhc.3 This gene encodes a protein that contains three ankyrin domains, a class I PDZ-binding motif and a sterile alpha motif. The encoded protein interacts with harmonin, which is associated with Usher syndrome type 1C. This protein plays a role in the development and maintenance of the auditory and visual systems and functions in the cohesion of hair bundles formed by inner ear sensory cells. Mutations in this gene are associated with combined auditory and vision loss. [provided by RefSeq, Sep 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB087502.1, BC137807.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Plays a role in pre-mRNA splicing by regulating the release and transfer of U4/U6.U5 tri-small nuclear ribonucleoprotein (tri- snRNP) complexes from their assembly site in Cajal bodies to nuclear speckles, thereby contributing to the assembly of the pre-catalytic spliceosome on target pre-mRNAs (By similarity). May also participate in recycling of snRNPs back to Cajal bodies during splicing (By similarity). Plays a role in regulating MAGI2-mediated endocytosis (By similarity). Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. Required for normal hearing. Part of a complex composed of USH1C, USH1G and MYO7A (By similarity). Interacts with USH1C (via the first PDZ domain) (PubMed:12588794). Interacts with PDZD7 (By similarity). Interacts with CDH23 and PCDH15; these interactions may recruit USH1G to the plasma membrane (PubMed:21436032). Interacts with intraflagellar transport proteins IFT20, IFT52 and IFT57 (By similarity). Interacts with splicing factors SF3B1, PRPF6, PRPF31 and SON (By similarity). Interacts with the U4/U6.U5 tri-small nuclear ribonucleoprotein (tri- snRNP) complex in the presence of pre-mRNAs (By similarity). Interacts (via SAM domain) with MAGI2 (via PDZ 6 domain); the interaction is triggered by phosphorylation of USH1G by CK2 and negatively regulates MAGI2-mediated endocytosis (PubMed:24608321). Q80T11; P97479: Myo7a; NbExp=4; IntAct=EBI-7418889, EBI-1149557; Q80T11; Q9ES64-3: Ush1c; NbExp=3; IntAct=EBI-7418889, EBI-7418919; Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane ; Peripheral membrane protein Cell projection, cilium cleus speckle Nucleus, Cajal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Photoreceptor inner segment Note=Detected at the tip of cochlear hair cell stereocilia. Recruited to the cell membrane via interaction with CDH23 or PCDH15 (PubMed:21436032). In photoreceptor cilia, detected predominantly at the cilium base (PubMed:31637240). Expressed in the pericentriolar region of the centrosome (PubMed:24608321). Detected in stereocilia from cochlear hair cells (at protein level). Detected in retinal photoreceptor cell cilia (at protein level) (PubMed:31637240). Highly expressed in the cochlea, testis, cerebellum and eye, and low levels in brain, thymus and spleen. Significant signals detected in the neurosensory epithelium of inner ear cochlea and saccule, especially in inner and outer hair cells. Low-level expression detected in 17.5 dpc embryos but not in embryos earlier than 15.5 dpc. Note=Defects in Ush1g are the cause of the Jackson shaker phenotypes (js). Jackson shaker mice carry recessive mutations predicted to inactivate Ush1g by frameshift resulting in a truncated protein lacking the C-terminal SAM domain. The js phenotype is characterized by deafness, abnormal behavior (circling and/or head- tossing) and degeneration of inner ear neuroepithelia. Defects in the formation of protein complex including Ush1g may disrupt stereocilia bundle in js mice. Mice are deaf, due to defects in hair cell bundles in the cochlea (PubMed:21436032). They develop circling behavior, probably due to balance problems (PubMed:21436032). Reduced expression of Ift20, Ift52 and Ift57 in the ciliary region of photoreceptor cells (PubMed:31637240). photoreceptor inner segment protein binding cytoplasm cytosol cytoskeleton plasma membrane sensory perception of sound actin cytoskeleton membrane spectrin binding photoreceptor connecting cilium ciliary basal body inner ear morphogenesis identical protein binding protein homodimerization activity photoreceptor cell maintenance sensory perception of light stimulus equilibrioception inner ear receptor cell differentiation inner ear receptor stereocilium organization uc007mhc.1 uc007mhc.2 uc007mhc.3 
ENSMUST00000103041.8 Nat9 ENSMUST00000103041.8 N-acetyltransferase 9 (GCN5-related, putative), transcript variant 1 (from RefSeq NM_001362889.1) ENSMUST00000103041.1 ENSMUST00000103041.2 ENSMUST00000103041.3 ENSMUST00000103041.4 ENSMUST00000103041.5 ENSMUST00000103041.6 ENSMUST00000103041.7 NAT9_MOUSE NM_001362889 Q3UG98 Q8C1G5 Q9D151 uc288djr.1 uc288djr.2 N-acetyltransferase that mediates the acetylation of the N- terminal residues of alpha- and beta-tubulin. Reaction=acetyl-CoA + N-terminal L-methionyl-[tubulin] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]; Xref=Rhea:RHEA:69607, Rhea:RHEA-COMP:17729, Rhea:RHEA-COMP:17730, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64731, ChEBI:CHEBI:133414; EC=2.3.1.308; Evidence=; Belongs to the acetyltransferase family. GNAT subfamily. Sequence=BAC25613.1; Type=Frameshift; Evidence=; protein acetylation N-acetyltransferase activity transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups macromolecular complex uc288djr.1 uc288djr.2 
ENSMUST00000103042.10 Tcea2 ENSMUST00000103042.10 transcription elongation factor A (SII), 2, transcript variant 1 (from RefSeq NM_009326.3) ENSMUST00000103042.1 ENSMUST00000103042.2 ENSMUST00000103042.3 ENSMUST00000103042.4 ENSMUST00000103042.5 ENSMUST00000103042.6 ENSMUST00000103042.7 ENSMUST00000103042.8 ENSMUST00000103042.9 NM_009326 O08667 Q9QVN7 TCEA2_MOUSE uc012cmu.1 uc012cmu.2 uc012cmu.3 uc012cmu.4 Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. Interacts with the basal transcription factor GTF2B. Interacts with REXO1 (By similarity). Nucleus. Testis and ovary specific. Specific to testicular germ cells. Expressed in testicular germ cells during and after meiosis in the course of spermatogenesis, while it is not expressed in premeiotic or early meiotic testicular germ cells. Belongs to the TFS-II family. nucleic acid binding DNA binding nucleus transcription, DNA-templated regulation of transcription, DNA-templated zinc ion binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc012cmu.1 uc012cmu.2 uc012cmu.3 uc012cmu.4 
ENSMUST00000103045.4 Stmn3 ENSMUST00000103045.4 stathmin-like 3 (from RefSeq NM_009133.3) ENSMUST00000103045.1 ENSMUST00000103045.2 ENSMUST00000103045.3 NM_009133 Q545T6 Q545T6_MOUSE Stmn3 uc008olt.1 uc008olt.2 Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. Belongs to the stathmin family. cytoplasm tubulin binding regulation of microtubule polymerization or depolymerization cytoplasmic microtubule organization neuron projection development uc008olt.1 uc008olt.2 
ENSMUST00000103051.9 Kcnq2 ENSMUST00000103051.9 potassium voltage-gated channel, subfamily Q, member 2, transcript variant 13 (from RefSeq NM_001302888.1) B7ZBW1 B7ZBW1_MOUSE ENSMUST00000103051.1 ENSMUST00000103051.2 ENSMUST00000103051.3 ENSMUST00000103051.4 ENSMUST00000103051.5 ENSMUST00000103051.6 ENSMUST00000103051.7 ENSMUST00000103051.8 Kcnq2 NM_001302888 uc290dlk.1 uc290dlk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein ion channel activity voltage-gated potassium channel activity potassium channel activity ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane transmembrane transport potassium ion transmembrane transport uc290dlk.1 uc290dlk.2 
ENSMUST00000103053.10 Nkain4 ENSMUST00000103053.10 Na+/K+ transporting ATPase interacting 4, transcript variant 1 (from RefSeq NM_021426.4) A2AWN3 A6MHQ2 A6MHQ3 ENSMUST00000103053.1 ENSMUST00000103053.2 ENSMUST00000103053.3 ENSMUST00000103053.4 ENSMUST00000103053.5 ENSMUST00000103053.6 ENSMUST00000103053.7 ENSMUST00000103053.8 ENSMUST00000103053.9 Fam77a NKAI4_MOUSE NM_021426 Q5EBQ3 Q9D1V9 Q9D8W0 Q9JMG4 uc008okf.1 uc008okf.2 uc008okf.3 Interacts with ATP1B1. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Transcript variant 1; IsoId=Q9JMG4-1; Sequence=Displayed; Name=2; Synonyms=Transcript variant 2; IsoId=Q9JMG4-2; Sequence=VSP_029302; Name=3; Synonyms=Transcript variant 3; IsoId=Q9JMG4-3; Sequence=VSP_029301; Ubiquitous. Expressed in multiple regions of the brain such as cerebral cortex, thalamus, hippocampus, olfactory bulb and brainstem as well as in cerebellum with low expression in granular cell layer. Belongs to the NKAIN family. regulation of sodium ion transport plasma membrane membrane integral component of membrane uc008okf.1 uc008okf.2 uc008okf.3 
ENSMUST00000103060.10 Wipi1 ENSMUST00000103060.10 WD repeat domain, phosphoinositide interacting 1 (from RefSeq NM_145940.2) D11Ertd498e ENSMUST00000103060.1 ENSMUST00000103060.2 ENSMUST00000103060.3 ENSMUST00000103060.4 ENSMUST00000103060.5 ENSMUST00000103060.6 ENSMUST00000103060.7 ENSMUST00000103060.8 ENSMUST00000103060.9 NM_145940 Q8BGE1 Q8R1A9 Q8R1C7 Q8R3E3 WIPI1_MOUSE uc007mcq.1 uc007mcq.2 uc007mcq.3 Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:22275429). Plays an important role in starvation- and calcium- mediated autophagy, as well as in mitophagy. Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes. There, it assists WIPI2 in the recruitment of ATG12-ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane. Together with WDR45/WIPI4, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Also plays a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6- phosphate receptor (MPR) recycling pathway (By similarity). Interacts with androgen receptor (AR) and the estrogen receptors ESR1 and ESR2. Interacts with WIPI2. Interacts with WDR45. Interacts with ATG16L1. May interact with NUDC. Golgi apparatus, trans-Golgi network Endosome Cytoplasmic vesicle, clathrin-coated vesicle Preautophagosomal structure membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton Note=Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R3E3-1; Sequence=Displayed; Name=2; IsoId=Q8R3E3-2; Sequence=VSP_016969; Name=3; IsoId=Q8R3E3-3; Sequence=VSP_016967, VSP_016968; The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane. Association to the membrane can also occur through binding to phosphatidylinositol 3-monophosphate (PI3P). The L/FRRG motif is required for recruitment to PtdIns3P. Belongs to the WD repeat PROPPIN family. Sequence=AAH24811.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH24883.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; autophagosome assembly pre-autophagosomal structure autophagosome membrane mitophagy receptor binding cytoplasm endosome Golgi apparatus trans-Golgi network cytosol cytoskeleton protein lipidation autophagy lipid binding cellular response to starvation endosome membrane membrane extrinsic component of membrane clathrin-coated vesicle estrogen receptor binding cytoplasmic vesicle phosphatidylinositol-3-phosphate binding pre-autophagosomal structure membrane protein localization to pre-autophagosomal structure vesicle targeting, trans-Golgi to endosome androgen receptor binding phosphatidylinositol-3,5-bisphosphate binding uc007mcq.1 uc007mcq.2 uc007mcq.3 
ENSMUST00000103061.3 Amz2 ENSMUST00000103061.3 Probable zinc metalloprotease. (from UniProt Q400C8) AMZ2_MOUSE BC025087 ENSMUST00000103061.1 ENSMUST00000103061.2 Q400C8 Q8BVM5 Q8K3B9 Q9D121 uc007mcj.1 uc007mcj.2 uc007mcj.3 uc007mcj.4 uc007mcj.5 Probable zinc metalloprotease. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role. ; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q400C8-1; Sequence=Displayed; Name=2; IsoId=Q400C8-2; Sequence=VSP_016984, VSP_016985; Predominantly expressed in testis. Expression in testis begins at about postnatal day 10 (P10), with adult level of expression reached at P20. Belongs to the peptidase M54 family. Sequence=AAH25087.1; Type=Erroneous initiation; Evidence=; Sequence=BAB23148.1; Type=Frameshift; Evidence=; Sequence=BAC35928.1; Type=Erroneous initiation; Evidence=; Sequence=BAC36674.1; Type=Erroneous initiation; Evidence=; cellular_component proteolysis peptidase activity metallopeptidase activity hydrolase activity metal ion binding uc007mcj.1 uc007mcj.2 uc007mcj.3 uc007mcj.4 uc007mcj.5 
ENSMUST00000103064.10 Pitpnc1 ENSMUST00000103064.10 phosphatidylinositol transfer protein, cytoplasmic 1, transcript variant 3 (from RefSeq NR_153311.1) A2A650 A2A651 ENSMUST00000103064.1 ENSMUST00000103064.2 ENSMUST00000103064.3 ENSMUST00000103064.4 ENSMUST00000103064.5 ENSMUST00000103064.6 ENSMUST00000103064.7 ENSMUST00000103064.8 ENSMUST00000103064.9 NR_153311 PITC1_MOUSE Q3TBB3 Q3U5F5 Q8K4R4 Q8K4R5 uc007mal.1 uc007mal.2 uc007mal.3 [Isoform 1]: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (By similarity). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (By similarity). [Isoform 2]: Specifically binds to phosphatidylinositol but not to other phospholipids and may play a role in the phosphoinositide- mediated signaling in the neural development. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out); Xref=Rhea:RHEA:38691, ChEBI:CHEBI:57880; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38692; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn- glycero-3-phosphate(out); Xref=Rhea:RHEA:36435, ChEBI:CHEBI:58608; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36436; Evidence=; [Isoform 1]: Cytoplasm [Isoform 2]: Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=mM-rdgBbeta; IsoId=Q8K4R4-1; Sequence=Displayed; Name=2; Synonyms=mM-rdgBbeta1; IsoId=Q8K4R4-2; Sequence=VSP_025549, VSP_025551; Name=3; IsoId=Q8K4R4-3; Sequence=VSP_025548, VSP_025550; Name=4; IsoId=Q8K4R4-4; Sequence=VSP_025546, VSP_025547; [Isoform 1]: Widely expressed in brain, with expression in the gray matters of pre- and postnatal brains. [Isoform 2]: Weakly expressed in brain and is rather confined to the embryonic stage. Belongs to the PtdIns transfer protein family. PI transfer class IIB subfamily. Sequence=CAM17314.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM17315.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM20627.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM25441.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM25442.1; Type=Erroneous gene model prediction; Evidence=; phospholipid transporter activity nucleus cytoplasm lipid transport signal transduction lipid binding phosphatidylinositol transporter activity phospholipid transport phosphatidylinositol binding phosphatidylinositol metabolic process uc007mal.1 uc007mal.2 uc007mal.3 
ENSMUST00000103066.10 Phactr3 ENSMUST00000103066.10 phosphatase and actin regulator 3, transcript variant 1 (from RefSeq NM_028806.2) ENSMUST00000103066.1 ENSMUST00000103066.2 ENSMUST00000103066.3 ENSMUST00000103066.4 ENSMUST00000103066.5 ENSMUST00000103066.6 ENSMUST00000103066.7 ENSMUST00000103066.8 ENSMUST00000103066.9 NM_028806 PHAR3_MOUSE Q8BYK5 Q8BYS8 Q8C058 Q9DB87 Scapin1 uc008ohk.1 uc008ohk.2 uc008ohk.3 uc008ohk.4 Binds PPP1CA and actin; thus inhibiting the protein phosphatase 1 (PP1) activity. Nucleus matrix Note=Localized to the nuclear matrix-intermediate filament scaffold. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BYK5-1; Sequence=Displayed; Name=2; IsoId=Q8BYK5-2; Sequence=VSP_009093; Name=3; IsoId=Q8BYK5-3; Sequence=VSP_009094; Name=4; IsoId=Q8BYK5-4; Sequence=VSP_009095; Belongs to the phosphatase and actin regulator family. actin binding protein phosphatase inhibitor activity nucleus nucleoplasm biological_process protein phosphatase 1 binding nuclear matrix protein phosphatase regulator activity negative regulation of phosphoprotein phosphatase activity regulation of phosphoprotein phosphatase activity uc008ohk.1 uc008ohk.2 uc008ohk.3 uc008ohk.4 
ENSMUST00000103071.4 Gh ENSMUST00000103071.4 growth hormone (from RefSeq NM_008117.3) ENSMUST00000103071.1 ENSMUST00000103071.2 ENSMUST00000103071.3 Gh1 NM_008117 P06880 Q544X1 SOMA_MOUSE uc007lys.1 uc007lys.2 uc007lys.3 uc007lys.4 Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Secreted. Belongs to the somatotropin/prolactin family. growth hormone receptor binding hormone activity extracellular region extracellular space nucleus mitochondrion trans-Golgi network cytosol plasma membrane neuroblast proliferation female pregnancy growth factor activity response to light stimulus positive regulation of glucose transport secretory granule response to nutrient levels response to food response to estradiol cellular response to insulin stimulus regulation of intracellular steroid hormone receptor signaling pathway response to cytokine positive regulation of multicellular organism growth positive regulation of tyrosine phosphorylation of STAT protein response to peptide hormone positive regulation of growth positive regulation of JAK-STAT cascade metal ion binding lung alveolus development animal organ development positive regulation of peptidyl-tyrosine phosphorylation positive regulation of neurogenesis growth hormone receptor signaling pathway cellular response to alkaline pH positive regulation of steroid hormone biosynthetic process cellular response to thyroid hormone stimulus negative regulation of neuron death uc007lys.1 uc007lys.2 uc007lys.3 uc007lys.4 
ENSMUST00000103075.11 Nsf ENSMUST00000103075.11 N-ethylmaleimide sensitive fusion protein (from RefSeq NM_008740.4) A2A646 ENSMUST00000103075.1 ENSMUST00000103075.10 ENSMUST00000103075.2 ENSMUST00000103075.3 ENSMUST00000103075.4 ENSMUST00000103075.5 ENSMUST00000103075.6 ENSMUST00000103075.7 ENSMUST00000103075.8 ENSMUST00000103075.9 NM_008740 NSF_MOUSE P46460 Q8BQ65 Q8C3R2 Q8CCT9 Q8CEF0 Q923C6 Skd2 uc007lvt.1 uc007lvt.2 uc007lvt.3 Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack GRIA2 leads to influence GRIA2 membrane cycling (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.6; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Homohexamer. Interacts with GABARAP and GABARAPL2. Interacts with GRIA2. Interacts with PLK2, leading to disrupt the interaction with GRIA2. Interacts with MUSK; may regulate MUSK endocytosis and activity (By similarity). Interacts with CDK16. P46460; Q62108: Dlg4; NbExp=5; IntAct=EBI-398006, EBI-300895; P46460; Q5S006: Lrrk2; NbExp=3; IntAct=EBI-398006, EBI-2693710; P46460; Q61006-3: Musk; NbExp=5; IntAct=EBI-398006, EBI-6308424; P46460; O35239: Ptpn9; NbExp=2; IntAct=EBI-398006, EBI-7297868; Cytoplasm. Phosphorylation at Ser-569 interferes with homohexamerization. Belongs to the AAA ATPase family. Sequence=CAM20943.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM23742.1; Type=Erroneous gene model prediction; Evidence=; SNARE binding nucleotide binding positive regulation of receptor recycling regulation of receptor internalization protein binding ATP binding cytoplasm Golgi stack cytosol plasma membrane potassium ion transport intracellular protein transport protein C-terminus binding postsynaptic density protein transport vesicle-mediated transport hydrolase activity ATPase activity syntaxin-1 binding Rab GTPase binding regulation of exocytosis protein kinase binding syntaxin binding PDZ domain binding D1 dopamine receptor binding macromolecular complex disassembly ionotropic glutamate receptor binding SNARE complex disassembly ATPase activity, coupled Golgi to plasma membrane protein transport ATP-dependent protein binding dendritic shaft myelin sheath macromolecular complex binding positive regulation of protein catabolic process metal ion binding Golgi vesicle docking uc007lvt.1 uc007lvt.2 uc007lvt.3 
ENSMUST00000103076.2 Spata32 ENSMUST00000103076.2 spermatogenesis associated 32 (from RefSeq NM_177801.3) Aep2 ENSMUST00000103076.1 NM_177801 Q8C5V0 SPT32_MOUSE Vad1.2 uc007ltz.1 uc007ltz.2 Interacts with syntaxin-1 and ACTB. Highly expressed in the testis and weakly in the brain and heart. actin binding spermatogenesis perinuclear region of cytoplasm uc007ltz.1 uc007ltz.2 
ENSMUST00000103077.2 Plcd3 ENSMUST00000103077.2 phospholipase C, delta 3, transcript variant 1 (from RefSeq NM_152813.3) A2AHR0 A2AHR1 ENSMUST00000103077.1 Kiaa1964 NM_152813 PLCD3_MOUSE Plcd3 Q3UME8 Q69Z55 Q8BL19 Q8K2J0 uc007ltf.1 uc007ltf.2 uc007ltf.3 uc007ltf.4 Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (PubMed:21187285). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33180; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 5 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. ; Strongly activated by phosphatidic acid. Inhibited by phosphatidylethanolamine (PtdEtn), phosphatidylcholine (PtdCho), sphingomyelin and phosphatidylserine (PtdSer) (By similarity). Membrane ; Peripheral membrane protein Cytoplasm Cleavage furrow Note=Localizes at the cleavage furrow during cytokinesis. Expressed in cerebellum and cerebral cortex. Expression increases during embryonic or postnatal brain development from cerebral cortex at 14 dpc to P7 stage. The C2 domain is a Ca(2+)-dependent membrane-targeting module. The PH domain mediates interaction with the surface membrane by binding to PIP2. Mice lacking Plcd1 and Plcd3 die between 11.5 and 13.5 dpc. They exhibit severe disruption of the normal labyrinth architecture in the placenta and decreased placental vascularization, as well as abnormal proliferation and apoptosis of trophoblasts in the labyrinth area. Furthermore, Plcd1 and Plcd3 double knockout embryos supplied with a normal placenta by the tetraploid aggregation method survive beyond 14.5 dpc, indicating that the embryonic lethality is caused by a defect in trophoblasts. Sequence=BAC32829.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32589.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=CAM22088.1; Type=Erroneous gene model prediction; Evidence=; angiogenesis phosphatidylinositol phospholipase C activity cytoplasm cytosol lipid metabolic process signal transduction phosphoric diester hydrolase activity membrane lipid catabolic process hydrolase activity cleavage furrow inositol trisphosphate biosynthetic process intracellular signal transduction regulation of cell proliferation metal ion binding phosphatidylinositol-mediated signaling release of sequestered calcium ion into cytosol labyrinthine layer blood vessel development uc007ltf.1 uc007ltf.2 uc007ltf.3 uc007ltf.4 
ENSMUST00000103079.4 Cttn ENSMUST00000103079.4 cortactin, transcript variant 1 (from RefSeq NM_007803.6) ENSMUST00000103079.1 ENSMUST00000103079.2 ENSMUST00000103079.3 Ems1 NM_007803 Q3UGC2 Q60598 SRC8_MOUSE uc009kqh.1 uc009kqh.2 uc009kqh.3 uc009kqh.4 Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:17403031). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (PubMed:22262902). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)- mediated endothelial cell (EC) barrier enhancement (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (By similarity). Part of a complex composed of NEDD9, AURKA and CTTN; within the complex NEDD9 acts as a scaffold protein and is required for complex formation (By similarity). Interacts (via N-terminus) with NEDD9 (PubMed:24574519). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Forms a complex with ABL1 and MYLK (By similarity). Interacts with SHANK2 and SHANK3 (via its SH3 domain). Interacts with PLXDC2 and SRCIN1. Interacts with SAMSN1 (via SH3 domain). Interacts (via SH3 domain) with ASAP1 (via Pro-rich region). Interacts (via SH3 domain) with DNM2. Interacts with ACTN1 (By similarity). Interacts with FER. Interacts with KCNA2 (via non-phosphorylated C-terminus). Interacts with FGD1. Interacts with ABL2 (PubMed:22297987). Interacts with CTTNBP2NL; this interaction may target CTTN to stress fibers. Interacts with CTTNBP2; this interaction may target CTTN at the cell cortex or dendritic spines. Interacts with KCNH1 (By similarity). Interacts (via SH3 domain) with DIP2A (via N- terminus); the interaction enhances CTTN acetylation and is required for proper synaptic transmission (PubMed:31600191). Q60598; Q99JY9: Actr3; NbExp=5; IntAct=EBI-397955, EBI-773994; Q60598; Q9JIY2: Cbll1; NbExp=4; IntAct=EBI-397955, EBI-7644904; Q60598; P30999: Ctnnd1; NbExp=4; IntAct=EBI-397955, EBI-529924; Q60598; P39054: Dnm2; NbExp=2; IntAct=EBI-397955, EBI-642337; Q60598; Q9JKY5: Hip1r; NbExp=4; IntAct=EBI-397955, EBI-642457; Q60598; P63141: Kcna2; NbExp=3; IntAct=EBI-397955, EBI-644033; Q60598; Q08460: Kcnma1; NbExp=2; IntAct=EBI-397955, EBI-1633915; Q60598; Q91YD9: Wasl; NbExp=4; IntAct=EBI-397955, EBI-642417; Q60598; P61157: ACTR3; Xeno; NbExp=4; IntAct=EBI-397955, EBI-351419; Q60598; Q8X482: espF(U); Xeno; NbExp=6; IntAct=EBI-397955, EBI-22229752; Q60598; Q9UBN7: HDAC6; Xeno; NbExp=3; IntAct=EBI-397955, EBI-301697; Q60598; O43312: MTSS1; Xeno; NbExp=2; IntAct=EBI-397955, EBI-473954; Q60598; Q7DB77: tir; Xeno; NbExp=4; IntAct=EBI-397955, EBI-6480811; Q60598; O08816: Wasl; Xeno; NbExp=2; IntAct=EBI-397955, EBI-6142604; Q60598; Q95107: WASL; Xeno; NbExp=2; IntAct=EBI-397955, EBI-6162776; Q60598; O43516: WIPF1; Xeno; NbExp=4; IntAct=EBI-397955, EBI-346356; Cytoplasm, cytoskeleton Cell projection, lamellipodium Cell projection, ruffle. Cell projection, dendrite. Cell projection Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, podosome Cell junction Cell junction, focal adhesion Membrane, clathrin-coated pit Cell projection, dendritic spine. Cytoplasm, cell cortex Endoplasmic reticulum Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers. In the presence of CTTNBP2, localizes at the cell cortex. In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft. Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity). Expressed in most tissues, except in B-lymphocytes or plasma cells. The SH3 motif may mediate binding to the cytoskeleton. Acetylated. Phosphorylated by FER. Phosphorylated in response to FGR activation (PubMed:7693700). Phosphorylation by SRC promotes MYLK binding (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (By similarity). Phosphorylated by PTK2/FAK1 in response to cell adhesion (By similarity). Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associate with filamentous actin. ruffle podosome protein binding profilin binding cytoplasm Golgi apparatus cytosol cytoskeleton actin filament plasma membrane clathrin-coated pit focal adhesion cell cortex intracellular protein transport endocytosis receptor-mediated endocytosis substrate-dependent cell migration, cell extension voltage-gated potassium channel complex postsynaptic density membrane lamellipodium actin filament polymerization cell junction dendrite site of polarized growth regulation of axon extension regulation of actin filament polymerization positive regulation of actin filament polymerization cortical cytoskeleton cortical actin cytoskeleton actin cytoskeleton reorganization cell projection dendritic spine intracellular membrane-bounded organelle postsynaptic membrane positive regulation of axon extension positive regulation of smooth muscle contraction focal adhesion assembly neuron projection morphogenesis cell motility actin filament binding positive regulation of dendritic spine morphogenesis proline-rich region binding Arp2/3 complex binding dendritic spine maintenance lamellipodium organization postsynaptic actin cytoskeleton modification of postsynaptic actin cytoskeleton postsynaptic actin cytoskeleton organization glutamatergic synapse regulation of mitophagy mitotic spindle midzone negative regulation of extrinsic apoptotic signaling pathway growth cone uc009kqh.1 uc009kqh.2 uc009kqh.3 uc009kqh.4 
ENSMUST00000103081.10 Adam11 ENSMUST00000103081.10 a disintegrin and metallopeptidase domain 11, transcript variant 2 (from RefSeq NM_009613.3) A2AUA8 ADA11_MOUSE ENSMUST00000103081.1 ENSMUST00000103081.2 ENSMUST00000103081.3 ENSMUST00000103081.4 ENSMUST00000103081.5 ENSMUST00000103081.6 ENSMUST00000103081.7 ENSMUST00000103081.8 ENSMUST00000103081.9 Mdc NM_009613 Q9R1V4 uc007lsi.1 uc007lsi.2 uc007lsi.3 uc007lsi.4 uc007lsi.5 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit defects in spatial learning, motor coordination and altered perception of pain. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, May 2016]. Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress (PubMed:26269648). Plays a role in spatial learning and motor coordination (PubMed:16504143). Involved in the nociceptive pain response to chemical-derived stimulation (PubMed:16729981). Interacts with LGI1 and LGI4 (PubMed:18974846). Interacts with KCNA1/KV1.1, KCNA2/KV1.2, DLG4/PSD-95 and ADAM22 (PubMed:26269648). Presynaptic cell membrane ; Single-pass type I membrane protein. Perikaryon Cell projection, axon Note=Localizes to basket cell terminals and pinceaux. Abundantly expressed in cerebellar cortex basket cell terminals and pinceaux, weakly expressed in Purkinje cells (at protein level) (PubMed:26269648). Weakly expressed in the heart (PubMed:10433968). Abundantly in expressed in neurons throughout the central nervous system including the telencephalon, diencephalic and brainstem nuclei, cerebellum and spinal cord (PubMed:12088751, PubMed:10433968). Expressed in the peripheral nervous system trigeminal and dorsal root ganglia (PubMed:12088751). Expressed in the ganglion and bipolar cells of the retinae and weakly in the cornea of the eyes (PubMed:12088751). Expressed in the hepatocytes of the parenchyma and hepatic lobules of the liver (PubMed:12088751, PubMed:10433968). Expressed in distinct focal areas in the juxtamedullary cortex of the kidney (PubMed:12088751). Expressed in spermatocytes in the seminiferous tubules of the testes (PubMed:12088751, PubMed:10433968). Expressed in the stratum spinosum of the stratified squamous epithelia of the tongue and esophagus (PubMed:12088751). Abundantly expressed in the neural crest-derived structures with low expression in the neural tube at 10 dpc (PubMed:12088751). Expressed in the dorsal root ganglia from 10 to 17 dpc (PubMed:12088751). Expression in the neural tube increases from 11 dpc to 13dpc, at 13 dpc expression is particularly abundant in the diencephalon, brainstem and spinal cord (PubMed:12088751). Expression increases from 13 dpc to postnatal day 1.5 (P1.5) in the telencephalon, whereas expression in the diencephalic and brainstem decreases over this period (PubMed:12088751). Expressed weakly in the developing heart at 13dpc but not at later developmental stages (PubMed:12088751). Expressed weaky in the kidney from 13dpc through to adulthood (PubMed:12088751). Initially expressed in the retinae at 15 dpc, expression is maintained through to adulthood (PubMed:12088751). Abundantly expressed in brown fat beginning at 17 dpc, expression levels are reduced to a low level at P1.5 (PubMed:12088751). A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor. The precursor is cleaved by a furin endopeptidase. Morphologically normal, including normal hippocampus and cerebellum morphology (PubMed:16504143). Develop a stress response that includes stationary stance progressing to a high amplitude coarse truncal tremor and ataxic gait when exposed to cold- water swim (PubMed:26269648). Loss of KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals results in loss of ephaptic inhibitory synchronization of Purkinje cell firing (PubMed:26269648). Impaired spatial learning and motor coordination (PubMed:16504143). Decrease in pain response to chemical stimuli such as subcutaneous injection of formalin or acetic acid (PubMed:16729981). metalloendopeptidase activity protein binding proteolysis metallopeptidase activity membrane integral component of membrane uc007lsi.1 uc007lsi.2 uc007lsi.3 uc007lsi.4 uc007lsi.5 
ENSMUST00000103084.4 Zfp334 ENSMUST00000103084.4 zinc finger protein 334 (from RefSeq NM_178411.3) A2A4U6 A2A4U6_MOUSE ENSMUST00000103084.1 ENSMUST00000103084.2 ENSMUST00000103084.3 NM_178411 Zfp334 uc008nxq.1 uc008nxq.2 uc008nxq.3 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc008nxq.1 uc008nxq.2 uc008nxq.3 
ENSMUST00000103085.8 Zfp663 ENSMUST00000103085.8 zinc finger protein 663, transcript variant 4 (from RefSeq NM_001379476.1) ENSMUST00000103085.1 ENSMUST00000103085.2 ENSMUST00000103085.3 ENSMUST00000103085.4 ENSMUST00000103085.5 ENSMUST00000103085.6 ENSMUST00000103085.7 Gm1008 NM_001379476 Q6NXM6 Q6NXM6_MOUSE Zfp663 uc008nxp.1 uc008nxp.2 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008nxp.1 uc008nxp.2 
ENSMUST00000103086.4 Itga2b ENSMUST00000103086.4 integrin alpha 2b (from RefSeq NM_010575.3) ENSMUST00000103086.1 ENSMUST00000103086.2 ENSMUST00000103086.3 ITA2B_MOUSE NM_010575 Q3U3R7 Q64229 Q9QUM0 Q9Z2M0 uc007lrx.1 uc007lrx.2 uc007lrx.3 Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. Interacts (via C-terminus cytoplasmic tail region) with CIB1; the interaction is direct and calcium-dependent. Interacts (via C-terminus cytoplasmic tail region) with CIB2, CIB3 and CIB4; the interactions are stabilized/increased in a calcium and magnesium-dependent manner (By similarity). ITGA2B:ITGB3 interacts with PPIA/CYPA; the interaction is ROS and PPIase activity-dependent and is increased in the presence of thrombin (PubMed:24429998). Membrane; Single-pass type I membrane protein. Belongs to the integrin alpha chain family. positive regulation of leukocyte migration focal adhesion cell adhesion cell-matrix adhesion integrin-mediated signaling pathway integrin complex external side of plasma membrane cell surface membrane integral component of membrane identical protein binding metal ion binding extracellular matrix binding fibrinogen binding extracellular exosome platelet aggregation uc007lrx.1 uc007lrx.2 uc007lrx.3 
ENSMUST00000103092.9 Ctsa ENSMUST00000103092.9 cathepsin A, transcript variant 1 (from RefSeq NM_008906.4) Ctsa ENSMUST00000103092.1 ENSMUST00000103092.2 ENSMUST00000103092.3 ENSMUST00000103092.4 ENSMUST00000103092.5 ENSMUST00000103092.6 ENSMUST00000103092.7 ENSMUST00000103092.8 G3X8T3 G3X8T3_MOUSE NM_008906 uc033hrk.1 uc033hrk.2 uc033hrk.3 This gene encodes a glycoprotein with deamidase, esterase and carboxypeptidase activities. The encoded protein associates with and provides a protective function to the lysosomal enzymes beta-galactosidase and neuraminidase. Deficiency of the related gene in humans results in galactosialidosis. The proprotein is processed into two shorter chains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. Belongs to the peptidase S10 family. carboxypeptidase activity serine-type carboxypeptidase activity nucleoplasm lysosomal membrane proteolysis peptidase activity hydrolase activity intracellular membrane-bounded organelle uc033hrk.1 uc033hrk.2 uc033hrk.3 
ENSMUST00000103094.11 Acot8 ENSMUST00000103094.11 acyl-CoA thioesterase 8, transcript variant 1 (from RefSeq NM_133240.2) Acot8 ENSMUST00000103094.1 ENSMUST00000103094.10 ENSMUST00000103094.2 ENSMUST00000103094.3 ENSMUST00000103094.4 ENSMUST00000103094.5 ENSMUST00000103094.6 ENSMUST00000103094.7 ENSMUST00000103094.8 ENSMUST00000103094.9 NM_133240 Q3U965 Q3U965_MOUSE uc008nwf.1 uc008nwf.2 uc008nwf.3 uc008nwf.4 Belongs to the C/M/P thioester hydrolase family. peroxisomal matrix acyl-CoA metabolic process palmitoyl-CoA hydrolase activity peroxisome fission dicarboxylic acid catabolic process negative regulation of CD4 biosynthetic process acyl-CoA hydrolase activity medium-chain acyl-CoA hydrolase activity uc008nwf.1 uc008nwf.2 uc008nwf.3 uc008nwf.4 
ENSMUST00000103095.5 Tnnc2 ENSMUST00000103095.5 troponin C2, fast (from RefSeq NM_009394.2) ENSMUST00000103095.1 ENSMUST00000103095.2 ENSMUST00000103095.3 ENSMUST00000103095.4 NM_009394 P20801 TNNC2_MOUSE Tncs uc008nvz.1 uc008nvz.2 uc008nvz.3 uc008nvz.4 Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Fast skeletal muscle. Skeletal muscle troponin C binds four calcium ions. Belongs to the troponin C family. skeletal muscle contraction actin binding calcium ion binding troponin complex regulation of muscle contraction metal ion binding calcium-dependent protein binding actin filament binding uc008nvz.1 uc008nvz.2 uc008nvz.3 uc008nvz.4 
ENSMUST00000103096.10 Wfdc3 ENSMUST00000103096.10 WAP four-disulfide core domain 3, transcript variant 1 (from RefSeq NM_027961.2) ENSMUST00000103096.1 ENSMUST00000103096.2 ENSMUST00000103096.3 ENSMUST00000103096.4 ENSMUST00000103096.5 ENSMUST00000103096.6 ENSMUST00000103096.7 ENSMUST00000103096.8 ENSMUST00000103096.9 NM_027961 Q14AE4 WFDC3_MOUSE Wap14 uc008nvt.1 uc008nvt.2 uc008nvt.3 Secreted molecular_function serine-type endopeptidase inhibitor activity cellular_component extracellular region biological_process negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc008nvt.1 uc008nvt.2 uc008nvt.3 
ENSMUST00000103097.10 Spint5 ENSMUST00000103097.10 serine protease inhibitor, Kunitz type 5 (from RefSeq NM_001040055.1) ENSMUST00000103097.1 ENSMUST00000103097.2 ENSMUST00000103097.3 ENSMUST00000103097.4 ENSMUST00000103097.5 ENSMUST00000103097.6 ENSMUST00000103097.7 ENSMUST00000103097.8 ENSMUST00000103097.9 Gm14316 NM_001040055 OTTMUSG00000016293 Q32ZM2 Q32ZM2_MOUSE Spint5 uc008nvs.1 uc008nvs.2 serine-type endopeptidase inhibitor activity extracellular space negative regulation of endopeptidase activity uc008nvs.1 uc008nvs.2 
ENSMUST00000103100.2 Eppin ENSMUST00000103100.2 epididymal peptidase inhibitor (from RefSeq NM_029325.2) A2A5G9 ENSMUST00000103100.1 EPPI_MOUSE NM_029325 Q9DA01 Spinlw1 uc008nvh.1 uc008nvh.2 uc008nvh.3 Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (By similarity). Monomer. Homodimer. Homomultimers. Interacts (via C-terminus) with SEMG1 (via 164-283 AA). Interacts with LTF. Found in a complex with LTF, CLU, EPPIN and SEMG1. Secreted. Cell surface. Note=Present on the surface of spermatozoa both before and after capacitation. Expressed in differentiated spermatogonia in testis. Expressed in spermatogonia cell lines GC-1 spg and GC-2spd(ts) as well as in the Leydig tumor cell line MLTC-1 (at protein level). Expressed specifically in epididymis and testis. Expressed predominantly on the postacrosomal region of mouse spermatozoa, in Sertoli cells, Leydig cells, and round spermatids in the testis, and in the principal cells of the cauda epididymidis epithelium. Androgen dependent. Down-regulated in Sertoli cell-selective androgen receptor knockout mice. acrosomal vesicle molecular_function serine-type endopeptidase inhibitor activity extracellular region extracellular space cytoplasm cell surface negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity defense response to bacterium uc008nvh.1 uc008nvh.2 uc008nvh.3 
ENSMUST00000103101.11 Pigt ENSMUST00000103101.11 phosphatidylinositol glycan anchor biosynthesis, class T, transcript variant 1 (from RefSeq NM_133779.3) A2A5G2 ENSMUST00000103101.1 ENSMUST00000103101.10 ENSMUST00000103101.2 ENSMUST00000103101.3 ENSMUST00000103101.4 ENSMUST00000103101.5 ENSMUST00000103101.6 ENSMUST00000103101.7 ENSMUST00000103101.8 ENSMUST00000103101.9 NM_133779 Ndap7 PIGT_MOUSE Q3U2X2 Q8BXQ2 Q99JA3 uc008nvc.1 uc008nvc.2 uc008nvc.3 Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates (By similarity). Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Forms a complex with PIGK/GPI8, PIGS, PIGU and GPAA1/GAA1. Has a critical role in maintaining the complex by stabilizing the expression of GPAA1 and GPI8 and linking them to PIGS (By similarity). Endoplasmic reticulum membrane; Single-pass type I membrane protein. The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity. Belongs to the PIGT family. Sequence=AAH34175.1; Type=Erroneous initiation; Evidence=; Sequence=AAK32809.1; Type=Erroneous initiation; Evidence=; Sequence=BAB39711.1; Type=Erroneous initiation; Evidence=; Sequence=CAC34729.1; Type=Erroneous initiation; Evidence=; cytoplasm endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process membrane integral component of membrane attachment of GPI anchor to protein neuron differentiation cytoplasmic vesicle GPI-anchor transamidase complex neuron apoptotic process GPI-anchor transamidase activity uc008nvc.1 uc008nvc.2 uc008nvc.3 
ENSMUST00000103104.2 Matn4 ENSMUST00000103104.2 matrilin 4, transcript variant 2 (from RefSeq NM_001252563.1) ENSMUST00000103104.1 F2Z3U4 F2Z3U4_MOUSE Matn4 NM_001252563 uc029uia.1 uc029uia.2 calcium ion binding uc029uia.1 uc029uia.2 
ENSMUST00000103105.10 Aoc3 ENSMUST00000103105.10 amine oxidase, copper containing 3 (from RefSeq NM_009675.2) A2A4I7 AOC3_MOUSE ENSMUST00000103105.1 ENSMUST00000103105.2 ENSMUST00000103105.3 ENSMUST00000103105.4 ENSMUST00000103105.5 ENSMUST00000103105.6 ENSMUST00000103105.7 ENSMUST00000103105.8 ENSMUST00000103105.9 NM_009675 O70423 Q66JM4 Q9R055 Vap1 uc007lop.1 uc007lop.2 uc007lop.3 uc007lop.4 Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (By similarity). Reaction=an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:16153, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478, ChEBI:CHEBI:28938, ChEBI:CHEBI:58001; EC=1.4.3.21; Evidence=; Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Note=Binds 1 copper ion per subunit. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 calcium ions per subunit. ; Name=L-topaquinone; Xref=ChEBI:CHEBI:79027; Evidence=; Note=Contains 1 topaquinone per subunit. ; Homodimer; disulfide-linked (By similarity). Forms a heterodimer with AOC2 (By similarity). Membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O70423-1; Sequence=Displayed; Name=2; IsoId=O70423-2; Sequence=VSP_016604; N- and O-glycosylated. Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. Belongs to the copper/topaquinone oxidase family. leukocyte migration involved in inflammatory response positive regulation of acute inflammatory response positive regulation of leukocyte migration copper ion binding calcium ion binding extracellular space cytoplasm early endosome endoplasmic reticulum Golgi apparatus plasma membrane microvillus cell adhesion primary amine oxidase activity regulation of blood pressure amine metabolic process cell surface positive regulation of glucose transport membrane integral component of membrane oxidoreductase activity response to immobilization stress eating behavior protein homodimerization activity intracellular membrane-bounded organelle response to antibiotic metal ion binding protein heterodimerization activity quinone binding tryptamine:oxygen oxidoreductase (deaminating) activity aminoacetone:oxygen oxidoreductase(deaminating) activity aliphatic-amine oxidase activity phenethylamine:oxygen oxidoreductase (deaminating) activity oxidation-reduction process negative regulation of primary amine oxidase activity uc007lop.1 uc007lop.2 uc007lop.3 uc007lop.4 
ENSMUST00000103107.5 Cntd1 ENSMUST00000103107.5 cyclin N-terminal domain containing 1 (from RefSeq NM_026562.2) CNTD1_MOUSE Cntd Cntd1 ENSMUST00000103107.1 ENSMUST00000103107.2 ENSMUST00000103107.3 ENSMUST00000103107.4 NM_026562 Q9D995 Q9D9L8 uc007loi.1 uc007loi.2 uc007loi.3 Plays a role in the different steps of crossover formation during meiotic recombination (PubMed:24891606, PubMed:32640224, PubMed:32555348). Participates in the crossover differentiation step of crossover-specific recombination intermediates through its interaction with PRR19 (PubMed:32555348). In addition, stimulates crossover formation through the interactions with RFC3 and RFC4 and simultaneously regulates cell-cycle progression through interactions with CDC34 and subsequent ubiquitination of WEE1 (PubMed:32640224). May also participates in an active deselection process that destabilizes or removes excess pre-CO intermediates (PubMed:24891606). Interacts with PRR19; this interaction promotes crossover formation (PubMed:32555348). Interacts with RFC3 and RFC4; these interactions facilitate crossover formation (PubMed:32640224). Interacts with CDC34; this interaction regulates the cell-cycle progression (PubMed:32640224). Nucleus Cytoplasm Chromosome Note=Shuttles between the nucleus and cytoplasm in a stage-specific manner of prophase I cells (PubMed:32640224). Co-localized at crossover sites with PRR19 (PubMed:32555348). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D995-1; Sequence=Displayed; Name=2 ; IsoId=Q9D995-3; Sequence=VSP_061282; Isoform 2 is expressed in spermatocyte. Homozygous knockout mice for CNTD1 are grossly similar to wild-type, surviving into adulthood and exhibiting appropriate mating behavior. Males are sterile with a decreased testis size. Females are also sterile. Sequence=BAB24728.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; molecular_function cellular_component reciprocal meiotic recombination spermatogenesis uc007loi.1 uc007loi.2 uc007loi.3 
ENSMUST00000103108.8 Wnk4 ENSMUST00000103108.8 WNK lysine deficient protein kinase 4 (from RefSeq NM_175638.3) A2A4J7 ENSMUST00000103108.1 ENSMUST00000103108.2 ENSMUST00000103108.3 ENSMUST00000103108.4 ENSMUST00000103108.5 ENSMUST00000103108.6 ENSMUST00000103108.7 NM_175638 Prkwnk4 Q4VAC1 Q80UE6 Q80XB5 Q80XN2 Q8R0N0 Q8R340 WNK4_MOUSE Wnk4 uc007loe.1 uc007loe.2 uc007loe.3 uc007loe.4 Serine/threonine-protein kinase component of the WNK4- SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (PubMed:12515852, PubMed:14608358, PubMed:16964266, PubMed:17488636, PubMed:17975670, PubMed:17360470, PubMed:19633012, PubMed:19240212, PubMed:21486947). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:21486947). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17488636, PubMed:19633012, PubMed:21486947). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (PubMed:14608358, PubMed:16964266, PubMed:17975670). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (PubMed:14608358, PubMed:17488636, PubMed:17975670, PubMed:19633012, PubMed:21486947). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (PubMed:14608358, PubMed:16403833, PubMed:17673510, PubMed:21317537). Also inhbits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase- independent mechanism (PubMed:17360470). May also phosphorylate NEDD4L (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activation requires autophosphorylation of Ser-328 and Ser-332 (By similarity). Autophosphorylation and subsequent activation is inhibited by increases in intracellular ionic strength: Cl(-) potently inhibits WNK4 kinase activity via direct binding (By similarity). Also inhibited by K(+) ions (PubMed:33439774). Interacts with the C-terminal region of KCNJ1 (PubMed:14608358). Interacts with WNK1 and WNK3 (PubMed:17975670). Interacts with KLHL3 (By similarity). Q80UE6; P69744: Trpv5; NbExp=2; IntAct=EBI-295378, EBI-538447; Q80UE6; O00141: SGK1; Xeno; NbExp=2; IntAct=EBI-295378, EBI-1042854; Q80UE6; Q13507-3: TRPC3; Xeno; NbExp=2; IntAct=EBI-295378, EBI-15563545; Cell junction, tight junction Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct (PubMed:11498583). WNK4 is part of the tight junction complex (PubMed:11498583). Locates to the distal convoluted tubule, the medullary collecting duct and the cortical collecting duct of the kidney (PubMed:11498583). Expressed in pancreatic duct (PubMed:21317537). The RFXV motif mediates recognition with downstream kinases OXSR1/OSR1 and STK39/SPAK. Autophosphorylated at Ser-328 and Ser-332, promoting its activation (By similarity). Phosphorylated by WNK1 and WNK3 (PubMed:17975670). Phosphorylated at Ser-572 in a MAP3K15/ASK3- dependent process in response to osmotic stress or hypotonic low- chloride stimulation (By similarity). Ubiquitinated by the BCR(KLHL3) complex, leading to its degradation. Also ubiquitinated by the BCR(KLHL2) complex. Embryonic lethality (PubMed:19633012). Hypomorphic mice do not display hypokalemia and metabolic alkalosis, but show low blood pressure and increased Na(+) and K(+) excretion under low-salt diet (PubMed:19633012). Phosphorylation of OXSR1/OSR1, STK39/SPAK and SLC12A3/NCC is significantly reduced in the hypomorphic mice (PubMed:19633012). Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins. Sequence=AAH26679.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH43677.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAO25619.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm cytosol bicellular tight junction protein phosphorylation ion transport chloride transport protein localization negative regulation of sodium ion transport membrane kinase activity phosphorylation transferase activity chloride channel inhibitor activity potassium channel inhibitor activity cell junction cellular chloride ion homeostasis positive regulation of ion transmembrane transporter activity intracellular signal transduction regulation of cellular process ion homeostasis renal sodium ion absorption distal tubule morphogenesis negative regulation of pancreatic juice secretion positive regulation of potassium ion import positive regulation of sodium ion transmembrane transporter activity uc007loe.1 uc007loe.2 uc007loe.3 uc007loe.4 
ENSMUST00000103109.4 Cntnap1 ENSMUST00000103109.4 contactin associated protein-like 1 (from RefSeq NM_016782.2) A2A4K6 CNTP1_MOUSE ENSMUST00000103109.1 ENSMUST00000103109.2 ENSMUST00000103109.3 NM_016782 Nrxn4 O54991 uc007lnt.1 uc007lnt.2 uc007lnt.3 Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons (PubMed:25378149). Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells (PubMed:25378149, PubMed:11395000). Interacts with CNTN1/contactin in cis form. Membrane ; Single-pass type I membrane protein Cell junction, paranodal septate junction Expressed in brain. In myelinated nerve fibers predominantly found in paranodal axoglial junctions. In the internodal region of myelinated axons in the CNS and the PNS also found as a thin line apposing the inner mesaxon of the myelin sheath. In PNS neurons this line forms a circumferential ring that apposes the innermost aspect of Schmidt-Lanterman incisures. Mutant mice exhibit tremor, ataxia, and significant motor paresis. Normal paranodal junctions fail to form, and the organization of the paranodal loops is disrupted. Contactin is undetectable in the paranodes, and potassium channels are displaced from the juxtaparanodal into the paranodal domains. Also results in a severe decrease in peripheral nerve conduction velocity (PubMed:11395000, PubMed:25378149). Double mutants CNTNAP1 and CNTNAP2 have wider Ranvier nodes compared to wild-type littermates (PubMed:25378149). Belongs to the neurexin family. protein localization to paranode region of axon plasma membrane septate junction cytoskeleton organization cell adhesion membrane integral component of membrane SH3 domain binding neuronal action potential propagation central nervous system myelination myelination in peripheral nervous system cell junction axon paranodal junction assembly neuron projection development paranodal junction paranode region of axon myelin sheath presynaptic active zone membrane neuron projection morphogenesis neuromuscular process controlling posture neuromuscular process controlling balance protein localization to juxtaparanode region of axon uc007lnt.1 uc007lnt.2 uc007lnt.3 
ENSMUST00000103111.9 Zhx3 ENSMUST00000103111.9 Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. (from UniProt Q8C0Q2) AK147259 ENSMUST00000103111.1 ENSMUST00000103111.2 ENSMUST00000103111.3 ENSMUST00000103111.4 ENSMUST00000103111.5 ENSMUST00000103111.6 ENSMUST00000103111.7 ENSMUST00000103111.8 Kiaa0395 Q80U14 Q8C0Q2 Tix1 ZHX3_MOUSE uc008nre.1 uc008nre.2 uc008nre.3 Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. Homodimer (via homeobox domain 1). Heterodimer with ZHX1 (via homeobox domain 1). Heterodimer with ZHX2 (via homeobox domain 1). Heterodimerization with ZHX1 is a prerequisite for repressor activity. Interacts with NFYA. Nucleus Ubiquitously expressed. Belongs to the ZHX family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus nucleoplasm cell cortex cell differentiation protein homodimerization activity positive regulation of osteoblast differentiation negative regulation of transcription, DNA-templated metal ion binding protein heterodimerization activity uc008nre.1 uc008nre.2 uc008nre.3 
ENSMUST00000103119.10 Zfp385c ENSMUST00000103119.10 zinc finger protein 385C, transcript variant 5 (from RefSeq NM_177790.4) A2A5E6 ENSMUST00000103119.1 ENSMUST00000103119.2 ENSMUST00000103119.3 ENSMUST00000103119.4 ENSMUST00000103119.5 ENSMUST00000103119.6 ENSMUST00000103119.7 ENSMUST00000103119.8 ENSMUST00000103119.9 NM_177790 Q14AS5 Q8C8X1 Z385C_MOUSE Zfp385c Znf385c uc007llv.1 uc007llv.2 uc007llv.3 uc007llv.4 Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2A5E6-1; Sequence=Displayed; Name=2; IsoId=A2A5E6-2; Sequence=VSP_031547; nucleic acid binding nucleus zinc ion binding metal ion binding uc007llv.1 uc007llv.2 uc007llv.3 uc007llv.4 
ENSMUST00000103120.5 Cnp ENSMUST00000103120.5 2',3'-cyclic nucleotide 3' phosphodiesterase, transcript variant 2 (from RefSeq NM_009923.2) Cnp Cnp1 ENSMUST00000103120.1 ENSMUST00000103120.2 ENSMUST00000103120.3 ENSMUST00000103120.4 NM_009923 Q3TYV5 Q3TYV5_MOUSE uc007llo.1 uc007llo.2 uc007llo.3 uc007llo.4 May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Reaction=a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 2'- phosphate + H(+); Xref=Rhea:RHEA:14489, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:66954, ChEBI:CHEBI:78552; EC=3.1.4.37; Evidence= Exists as monomers and homodimers. Melanosome Membrane ; Lipid-anchor Belongs to the 2H phosphoesterase superfamily. CNPase family. microtubule cytoskeleton organization RNA binding 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity extracellular space nucleus nucleoplasm cytoplasm mitochondrial outer membrane mitochondrial inner membrane cytosol plasma membrane microvillus aging cyclic nucleotide catabolic process membrane hydrolase activity cyclic nucleotide binding forebrain development pseudopodium response to lipopolysaccharide myelin sheath abaxonal region myelin sheath adaxonal region melanosome cell projection myelin sheath regulation of mitochondrial membrane permeability perinuclear region of cytoplasm uc007llo.1 uc007llo.2 uc007llo.3 uc007llo.4 
ENSMUST00000103122.10 Tgm2 ENSMUST00000103122.10 transglutaminase 2, C polypeptide (from RefSeq NM_009373.3) ENSMUST00000103122.1 ENSMUST00000103122.2 ENSMUST00000103122.3 ENSMUST00000103122.4 ENSMUST00000103122.5 ENSMUST00000103122.6 ENSMUST00000103122.7 ENSMUST00000103122.8 ENSMUST00000103122.9 NM_009373 O88901 P21981 Q3TLV2 Q8C217 Q91VG9 Q9R1F7 TGM2_MOUSE Tgm2 uc008npr.1 uc008npr.2 uc008npr.3 Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (By similarity). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (By similarity). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:11274171, PubMed:11113189, PubMed:20489165). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (By similarity). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (By similarity). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:12810961, PubMed:15905580). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:32116663). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (By similarity). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (By similarity). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (By similarity). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (PubMed:32116663). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (By similarity). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (By similarity). May also act as an isopeptidase cleaving the previously formed cross-links (By similarity). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:11274171). Reaction=L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L- lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:54816, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:14005, ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:30011, ChEBI:CHEBI:138370; EC=2.3.2.13; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54817; Evidence=; Reaction=L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl- [protein] + NH4(+); Xref=Rhea:RHEA:66552, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:17052, ChEBI:CHEBI:28938, ChEBI:CHEBI:30011, ChEBI:CHEBI:167174, ChEBI:CHEBI:350546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66553; Evidence=; Reaction=dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl- [protein] + NH4(+); Xref=Rhea:RHEA:66556, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:17053, ChEBI:CHEBI:28938, ChEBI:CHEBI:30011, ChEBI:CHEBI:59905, ChEBI:CHEBI:167175; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66557; Evidence=; Reaction=histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl- [protein] + NH4(+); Xref=Rhea:RHEA:66564, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:17056, ChEBI:CHEBI:28938, ChEBI:CHEBI:30011, ChEBI:CHEBI:58432, ChEBI:CHEBI:167179; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66565; Evidence=; Reaction=(R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)- noradrenalinyl-L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:66560, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:17054, ChEBI:CHEBI:28938, ChEBI:CHEBI:30011, ChEBI:CHEBI:72587, ChEBI:CHEBI:167178; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66561; Evidence=; Reaction=H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:16441, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:10208, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29973, ChEBI:CHEBI:30011; EC=3.5.1.44; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16442; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Acyltransferase activity is regulated by the binding of GTP and Ca(2+): inactivated by GTP, which stabilizes its closed structure, thereby obstructing the accessibility of substrates to the active sites. In contrast, Ca(2+) acts as a cofactor by inducing conformational change to the active open form. In absence of Ca(2+), Mg(2+) may bind Ca(2+)-binding sites, promoting GTP-binding and subsequent inhibition of the acyltransferase activity. Monomer. Interacts with phospholipase C; promoting alpha-1 adrenergic receptor signaling (By similarity). Interacts with PLCD1 (By similarity). Cytoplasm, cytosol Nucleus Chromosome Secreted, extracellular space, extracellular matrix Cell membrane Mitochondrion Note=Mainly localizes to the cytosol. Present at much lower level in the nucleus and chromatin. Also secreted via a non-classical secretion pathway to the extracellular matrix. Disulfide bond formation inactivates the calcium-dependent acyltransferase activity. Cys-370 can form disulfide bonds with both Cys-230 and Cys-371: formation of a disulfide bond between Cys-230 and Cys-370 facilitates formation of the disulfide between Cys-370 and Cys- 371, which promotes inactivation of the acyltransferase activity. May also form interchain disulfids between Cys-230 and Cys-370. Ca(2+) protects against disulfide bond formation and inactivation. Auto-transglutaminated: Forms covalent cross-links mediated by transglutaminase between Gln-632 and the epsilon-amino group of a lysine residue of itself or HMGB1, forming homopolymers and heteropolymers, respectively. S-nitrosylated, leading to inactivation of the acyltransferase activity. No visible phenotype in normal conditions (PubMed:11274171, PubMed:11113189). During apoptosis, mice display defective clearance of apoptotic cells in the thymus (PubMed:12810961). Moreover, inflammatory as well as autoimmune reactions develop spontaneously with age (PubMed:12810961). Defective clearance of apoptotic cells is caused by an impaired capacity of macrophages to engulf, but not to bind, apoptotic cells (PubMed:15905580). Mice also show glucose intolerance after intraperitoneal glucose loading: mice manifest a tendency to develop hypoglycemia after administration of exogenous insulin as a consequence of enhanced IRS2 phosphorylation (PubMed:12205028). Belongs to the transglutaminase superfamily. Transglutaminase family. blood vessel remodeling protein-glutamine gamma-glutamyltransferase activity calcium ion binding GTP binding cytoplasm mitochondrion endoplasmic reticulum cytosol plasma membrane G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway transaminase activity membrane transferase activity transferase activity, transferring acyl groups peptide cross-linking isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine protein domain specific binding extracellular matrix intrinsic component of plasma membrane negative regulation of endoplasmic reticulum calcium ion concentration positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling apoptotic cell clearance positive regulation of cell adhesion metal ion binding positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response protein homooligomerization positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway positive regulation of mitochondrial calcium ion concentration branching involved in salivary gland morphogenesis salivary gland cavitation uc008npr.1 uc008npr.2 uc008npr.3 
ENSMUST00000103123.10 Rprd1b ENSMUST00000103123.10 regulation of nuclear pre-mRNA domain containing 1B, transcript variant 2 (from RefSeq NM_027434.3) A0A0R4J195 A0A0R4J195_MOUSE ENSMUST00000103123.1 ENSMUST00000103123.2 ENSMUST00000103123.3 ENSMUST00000103123.4 ENSMUST00000103123.5 ENSMUST00000103123.6 ENSMUST00000103123.7 ENSMUST00000103123.8 ENSMUST00000103123.9 NM_027434 Rprd1b uc008npm.1 uc008npm.2 uc008npm.3 Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Associates with the RNA polymerase II complex. Belongs to the UPF0400 (RTT103) family. uc008npm.1 uc008npm.2 uc008npm.3 
ENSMUST00000103124.11 Hap1 ENSMUST00000103124.11 huntingtin-associated protein 1, transcript variant 1 (from RefSeq NM_010404.3) ENSMUST00000103124.1 ENSMUST00000103124.10 ENSMUST00000103124.2 ENSMUST00000103124.3 ENSMUST00000103124.4 ENSMUST00000103124.5 ENSMUST00000103124.6 ENSMUST00000103124.7 ENSMUST00000103124.8 ENSMUST00000103124.9 HAP1_MOUSE NM_010404 O35636 O35668 uc007lkx.1 uc007lkx.2 uc007lkx.3 uc007lkx.4 The protein encoded by this gene was first identified as a neuronal protein that binds the HD protein huntingtin. The protein also interacts with kinesin light chain, 14-3-3 proteins, and Abelson helper integration site 1 protein. The protein is involved in intracellular trafficking of vesicles and organelles, and lack of the protein results in neuronal death resembling the hypothalamic degeneration that occurs in Huntington's disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]. Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB regulating the number of Npyr1- expressing cells), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesiss; however, reports are conflicting: PubMed:21985783 reports that Hap1 is required for ciliogenesis in primary cortical neurons and proposes that HTT interacts with PCM1 through HAP1; PubMed:23532844 reports that mice with disrupted Hap1 display normal cilium formation and function. Involved in regulation of exocytosis. Isoform A but not isoform B seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. Self-associates. Interacts with HTT/huntingtin; enhanced by an expanded polyglutamine repeat within HTT. Isoform A interacts with DCTN1; decreased in presence of HTT with expanded polyglutamine repeat; decreased by phosphorylation of Hap1 isoform A at Thr-598. Isoform A interacts with KLC2; decreased by phosphorylation of Hap1 isoform A at Thr-598. Isoform A interacts with ITPR1 and APP. Isoform A interacts with AR; decreased by an expanded polyglutamine repeat within AR. Isoform A interacts with YWHAZ; enhanced by phosphorylation of Hap1 isoform A at Thr-598. Isoform A interacts with BDNF and SORT1; probably forming a complex involved in proBDNF trafficking, degradation and processing. Interacts with TBP, AHI1, HGS and KALRN. Interacts with KIF5A, KIF5B, KIF5C and GABRB3; indicative for an HAP1:KIF5 complex transporting a GABA(A) receptor as cargo. Interacts with ATXN3; in STBs. Interacts with NTRK2; HAP1 stabilizes association of NTRK2 with SORT1 preventing NTRK2 degradation. Interacts with CCDC113. O35668; Q8K3E5: Ahi1; NbExp=3; IntAct=EBI-473704, EBI-4280729; O35668-2; B2GV74: Klc2; Xeno; NbExp=3; IntAct=EBI-473719, EBI-978371; Cytoplasm Presynapse Cytoplasm, cytoskeleton Cell projection, dendritic spine Cell projection, dendrite Cell projection, axon Lysosome Endoplasmic reticulum Mitochondrion Nucleus Cytoplasmic vesicle, autophagosome Early endosome Cell projection, growth cone Note=Localizes to large nonmembrane- bound cytoplasmic bodies found in various types of neurons, called stigmoid bodies (STBs); STB formation is regulated by the ratio of isoform A to isoform B. In the nucleus localizes to nuclear rods. [Isoform B]: Cytoplasm Note=In NGF-stimulated PC2 cells isoform A can move anterogradely fom neurite cell body to neurite terminal and is localized to growth cone tips whereas isoform B stays in the cell body. [Isoform A]: Cell projection, growth cone Cell projection, neuron projection Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Presynapse Note=In NGF-stimulated PC2 cells isoform A can move anterogradely fom neurite cell body to neurite terminal and is localized to growth cone tips whereas isoform B stays in the cell body. Localization to neuronal processes and neurite tips is decreased by YWHAZ. Event=Alternative splicing; Named isoforms=2; Name=B; Synonyms=Long; IsoId=O35668-1; Sequence=Displayed; Name=A; Synonyms=Short; IsoId=O35668-2; Sequence=VSP_004279; Isoform A is phosphorylated on Thr-598. Depressed postnatal feeding behavior leading to premature death latest at P9. Degeneration in hypothalamic regions that control feeding behavior. receptor binding protein binding nucleus cytoplasm mitochondrion lysosome autophagosome endoplasmic reticulum centrosome centriole cytoskeleton protein targeting exocytosis autophagy synaptic vesicle anterograde axonal transport retrograde axonal transport protein localization positive regulation of neuron projection development protein transport inclusion body myosin binding regulation of exocytosis protein domain specific binding cerebellum development hypothalamus cell differentiation neurogenesis cell projection organization cell junction axon dendrite growth cone neuron projection development cytoplasmic vesicle positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity positive regulation of synaptic transmission, GABAergic positive regulation of neurotrophin production identical protein binding cell projection neuron projection axon terminus ion channel binding synapse positive regulation of epidermal growth factor receptor signaling pathway vesicle transport along microtubule neurotrophin TRK receptor signaling pathway mitochondrion distribution brain-derived neurotrophic factor binding perinuclear region of cytoplasm positive regulation of neurogenesis positive regulation of inclusion body assembly anterograde axonal transport of mitochondrion GABA-ergic synapse presynaptic cytosol postsynaptic cytosol negative regulation of beta-amyloid formation regulation of organelle transport along microtubule positive regulation of non-motile cilium assembly axon cytoplasm uc007lkx.1 uc007lkx.2 uc007lkx.3 uc007lkx.4 
ENSMUST00000103127.4 Krt35 ENSMUST00000103127.4 keratin 35 (from RefSeq NM_016880.2) B2RU48 ENSMUST00000103127.1 ENSMUST00000103127.2 ENSMUST00000103127.3 KRT35_MOUSE Krt1-24 Krt35 NM_016880 Q497I4 Q9Z2T8 uc011yex.1 uc011yex.2 uc011yex.3 There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). Belongs to the intermediate filament family. Sequence=AAD01693.1; Type=Erroneous initiation; Evidence=; Sequence=AAI40966.1; Type=Erroneous initiation; Evidence=; structural molecule activity intermediate filament uc011yex.1 uc011yex.2 uc011yex.3 
ENSMUST00000103130.8 Dsn1 ENSMUST00000103130.8 Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. (from UniProt Q9CYC5) AK139887 DSN1_MOUSE ENSMUST00000103130.1 ENSMUST00000103130.2 ENSMUST00000103130.3 ENSMUST00000103130.4 ENSMUST00000103130.5 ENSMUST00000103130.6 ENSMUST00000103130.7 Q9CYC5 Q9CYF2 Q9DA26 uc008nok.1 uc008nok.2 uc008nok.3 uc008nok.4 Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3 and CBX5. Interacts with KNSTRN. Nucleus Chromosome, centromere, kinetochore Note=Associated with the kinetochore. mitotic sister chromatid segregation MIS12/MIND type complex chromosome, centromeric region kinetochore condensed chromosome kinetochore nuclear MIS12/MIND complex spindle pole condensed nuclear chromosome inner kinetochore fibrillar center molecular_function nucleus chromosome nucleolus cytosol cell cycle chromosome segregation nuclear body cell division uc008nok.1 uc008nok.2 uc008nok.3 uc008nok.4 
ENSMUST00000103131.5 Krt10 ENSMUST00000103131.5 keratin 10 (from RefSeq NM_010660.2) A2A513 A2A513_MOUSE ENSMUST00000103131.1 ENSMUST00000103131.2 ENSMUST00000103131.3 ENSMUST00000103131.4 Krt10 NM_010660 uc007lir.1 uc007lir.2 uc007lir.3 uc007lir.4 Belongs to the intermediate filament family. cornified envelope structural molecule activity cytoplasm intermediate filament peptide cross-linking keratinocyte differentiation structural constituent of epidermis protein heterodimerization activity protein heterotetramerization uc007lir.1 uc007lir.2 uc007lir.3 uc007lir.4 
ENSMUST00000103132.10 Krt222 ENSMUST00000103132.10 keratin 222, transcript variant 1 (from RefSeq NM_172946.3) ENSMUST00000103132.1 ENSMUST00000103132.2 ENSMUST00000103132.3 ENSMUST00000103132.4 ENSMUST00000103132.5 ENSMUST00000103132.6 ENSMUST00000103132.7 ENSMUST00000103132.8 ENSMUST00000103132.9 KT222_MOUSE NM_172946 Q3UU52 Q68FD8 Q8CCX5 uc007lik.1 uc007lik.2 uc007lik.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CCX5-1; Sequence=Displayed; Name=2; IsoId=Q8CCX5-2; Sequence=VSP_034745; Belongs to the intermediate filament family. Sequence=BAE23776.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; structural molecule activity intermediate filament biological_process uc007lik.1 uc007lik.2 uc007lik.3 
ENSMUST00000103133.4 Smarce1 ENSMUST00000103133.4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (from RefSeq NM_020618.4) Baf57 ENSMUST00000103133.1 ENSMUST00000103133.2 ENSMUST00000103133.3 NM_020618 O54941 Q8BPD9 SMCE1_MOUSE uc007lii.1 uc007lii.2 uc007lii.3 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:12110891). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs)(PubMed:12145209). Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B), and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors- specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. May be a component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (ACTB)(PubMed:17640523). Interacts with BRDT (By similarity). Also binds to the SRC/p160 family of histone acetyltransferases (HATs) composed of NCOA1, NCOA2, and NCOA3. Interacts with RCOR1/CoREST, NR3C1 and ZMIM2/ZIMP7 (By similarity). Nucleus Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at 10.5-16.5 dpc. The HMG domain is essential for CD4 silencing and CD8 activation; mutation of this domain blocks thymus development. Ubiquitinated by TRIP12, leading to its degradation by the proteasome. Ubiquitination is prevented upon interaction between TRIP12 and SMARCC1 (By similarity). Sequence=BAC36233.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC36233.1; Type=Frameshift; Evidence=; Sequence=BAC36233.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence=; DNA binding RNA binding protein binding nucleus nucleoplasm chromatin organization nucleosome disassembly chromatin remodeling nervous system development N-acetyltransferase activity SWI/SNF complex ligand-dependent nuclear receptor binding neurogenesis ATP-dependent chromatin remodeling negative regulation of transcription, DNA-templated protein N-terminus binding npBAF complex nBAF complex uc007lii.1 uc007lii.2 uc007lii.3 
ENSMUST00000103134.4 Ccr7 ENSMUST00000103134.4 C-C motif chemokine receptor 7, transcript variant 1 (from RefSeq NM_007719.2) CCR7_MOUSE Cmkbr7 ENSMUST00000103134.1 ENSMUST00000103134.2 ENSMUST00000103134.3 Ebi1 Ebi1h NM_007719 P47774 Q8CAS2 uc007lih.1 uc007lih.2 uc007lih.3 Receptor for the MIP-3-beta chemokine. P47774; P20963: CD247; Xeno; NbExp=2; IntAct=EBI-8038963, EBI-1165705; Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. establishment of T cell polarity myeloid dendritic cell chemotaxis lymphocyte chemotaxis across high endothelial venule positive regulation of dendritic cell antigen processing and presentation regulation of tolerance induction to self antigen positive regulation of hypersensitivity positive regulation of humoral immune response G-protein coupled receptor activity chemokine receptor activity protein binding mitochondrion plasma membrane chemotaxis inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration activation of JUN kinase activity external side of plasma membrane cell surface positive regulation of macrophage chemotaxis positive regulation of T cell chemotaxis membrane integral component of membrane C-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding actin cytoskeleton organization response to lipopolysaccharide regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of tumor necrosis factor production response to prostaglandin E chemokine (C-C motif) ligand 19 binding chemokine (C-C motif) ligand 21 binding chemokine (C-C motif) ligand 19 signaling pathway chemokine (C-C motif) ligand 21 signaling pathway C-C motif chemokine 19 receptor activity C-C motif chemokine 21 receptor activity positive regulation of T cell proliferation positive regulation of GTPase activity negative thymic T cell selection positive regulation of T-helper 1 cell differentiation positive regulation of receptor-mediated endocytosis lymph node development homeostasis of number of cells regulation of interleukin-1 beta secretion positive regulation of interleukin-1 beta secretion positive regulation of phagocytosis positive regulation of T cell receptor signaling pathway positive regulation of filopodium assembly cell chemotaxis chemokine-mediated signaling pathway cellular response to cytokine stimulus response to nitric oxide interleukin-12 secretion positive regulation of neutrophil chemotaxis lymphocyte migration into lymph node mature conventional dendritic cell differentiation negative regulation of leukocyte apoptotic process positive regulation of cell motility positive regulation of thymocyte migration positive regulation of dendritic cell chemotaxis positive regulation of immunological synapse formation positive regulation of T cell costimulation positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation regulation of dendritic cell dendrite assembly uc007lih.1 uc007lih.2 uc007lih.3 
ENSMUST00000103137.10 Epb41l1 ENSMUST00000103137.10 erythrocyte membrane protein band 4.1 like 1, transcript variant 11 (from RefSeq NM_001368803.1) A2AUK5 A2AUK5_MOUSE ENSMUST00000103137.1 ENSMUST00000103137.2 ENSMUST00000103137.3 ENSMUST00000103137.4 ENSMUST00000103137.5 ENSMUST00000103137.6 ENSMUST00000103137.7 ENSMUST00000103137.8 ENSMUST00000103137.9 Epb4.1l1 Epb41l1 NM_001368803 uc008nnk.1 uc008nnk.2 uc008nnk.3 actin binding structural molecule activity cytoskeleton plasma membrane cytoskeletal protein binding cortical actin cytoskeleton organization uc008nnk.1 uc008nnk.2 uc008nnk.3 
ENSMUST00000103139.11 Thra ENSMUST00000103139.11 thyroid hormone receptor alpha, transcript variant 2 (from RefSeq NM_178060.4) A3KFN4 C-erba-alpha ENSMUST00000103139.1 ENSMUST00000103139.10 ENSMUST00000103139.2 ENSMUST00000103139.3 ENSMUST00000103139.4 ENSMUST00000103139.5 ENSMUST00000103139.6 ENSMUST00000103139.7 ENSMUST00000103139.8 ENSMUST00000103139.9 NM_178060 Nr1a1 P10685 P15827 P16416 P37241 P63058 Q542U8 Q63107 Q63195 Q63196 Q80Y90 Q99146 THA_MOUSE uc007lhe.1 uc007lhe.2 uc007lhe.3 uc007lhe.4 The protein encoded by this gene is one of several nuclear hormone receptors that bind thyroid hormones such as triiodothyronine and thyroxine with high affinity. The encoded protein is a transcription factor that can activate or repress transcription. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]. Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha- deltaE6 does not bind DNA, inhibits the activity of isoform Alpha-1, and stimulates myoblast differentiation. Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with AKAP13. Interacts with C1D. Interacts with TP53INP2. Interacts with PER2. Isoform alpha-2 and isoform alpha-1 interact with TACC1, but the interaction with alpha-1 is much weaker. The interaction with isoform alpha-1, but not alpha-2, is decreased in the presence of thyroid hormone T3 (PubMed:20078863). P63058; D4A055: Cacnb4; Xeno; NbExp=2; IntAct=EBI-6935292, EBI-8028403; Nucleus. [Isoform Alpha-deltaE6]: Cytoplasm. Note=Sequesters isoform Alpha-1 into this compartment. [Isoform Alpha-2]: Cytoplasm Nucleus Note=When overexpressed found in the cytoplasm where it colocalizes with TACC1. Event=Alternative splicing; Named isoforms=4; Name=Alpha-2; IsoId=P63058-1, P15827-1; Sequence=Displayed; Name=Alpha-1; IsoId=P63058-2, P15827-2; Sequence=VSP_003624; Name=Alpha-3; IsoId=P63058-3, P15827-3; Sequence=VSP_003625; Name=Alpha-deltaE6; IsoId=P63058-4; Sequence=VSP_038640, VSP_003624; Ubiquitous (Isoform Alpha-deltaE6). Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Isoform Alpha-deltaE6 lacks the hinge region that connects the modulating domain and the DNA binding domain. [Isoform Alpha-2]: Does not bind thyroid hormone T3. [Isoform Alpha-deltaE6]: Due to mismatches with the underlying genomic sequence that lie within a microexon, this isoform has been proposed to undergo RNA editing involving both base insertion and deletion. Belongs to the nuclear hormone receptor family. NR1 subfamily. Sequence=CAM46188.1; Type=Erroneous gene model prediction; Evidence=; negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding cartilage condensation ossification steroid receptor RNA activator RNA binding thyroid hormone mediated signaling pathway regulation of thyroid hormone mediated signaling pathway transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity single-stranded RNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus cytoplasm mitochondrion cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development brain development learning or memory regulation of heart contraction female courtship behavior transcription factor binding zinc ion binding response to cold hormone-mediated signaling pathway animal organ morphogenesis positive regulation of myotube differentiation TBP-class protein binding negative regulation of RNA polymerase II transcriptional preinitiation complex assembly protein domain specific binding cell differentiation erythrocyte differentiation ligand-dependent nuclear receptor transcription coactivator activity thyroid gland development chromatin DNA binding regulation of myeloid cell apoptotic process response to lipid signaling receptor activity protein homodimerization activity cytoplasmic sequestering of transcription factor steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding transcription regulatory region DNA binding intronic transcription regulatory region DNA binding macromolecular complex binding negative regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription from RNA polymerase II promoter metal ion binding protein heterodimerization activity protein dimerization activity regulation of lipid catabolic process Type I pneumocyte differentiation thyroid hormone binding positive regulation of canonical Wnt signaling pathway RNA polymerase II transcription factor complex negative regulation of DNA-templated transcription, initiation DNA binding uc007lhe.1 uc007lhe.2 uc007lhe.3 uc007lhe.4 
ENSMUST00000103141.4 Ikzf3 ENSMUST00000103141.4 IKAROS family zinc finger 3 (from RefSeq NM_011771.1) B1AQE6 ENSMUST00000103141.1 ENSMUST00000103141.2 ENSMUST00000103141.3 IKZF3_MOUSE NM_011771 O08900 Zfpn1a3 Znfn1a3 uc007lgm.1 uc007lgm.2 uc007lgm.3 Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Binds to GGGAA. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. Homodimer. Heterodimer with other IKAROS family members. Interacts with IKZF4 and IKZF5. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T- cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A (By similarity). Interacts with IKZF1. Nucleus Cytoplasm Expression is restricted to lymphoid tissues. Expressed at highest levels in spleen and at lower levels in the thymus and bone marrow. First detected in more committed lymphoid progenitors and strongly up-regulated as these differentiate into pre-T and pre-B cell precursors. C2H2-type 5 and C2H2-type 6 mediate homodimerization and heterodimerization. Belongs to the Ikaros C2H2-type zinc-finger protein family. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane response to bacterium regulation of B cell proliferation B cell activation identical protein binding protein homodimerization activity regulation of apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding regulation of B cell differentiation regulation of lymphocyte differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding protein heterodimerization activity uc007lgm.1 uc007lgm.2 uc007lgm.3 
ENSMUST00000103143.10 Fbxl20 ENSMUST00000103143.10 F-box and leucine-rich repeat protein 20 (from RefSeq NM_028149.1) A7YE80 ENSMUST00000103143.1 ENSMUST00000103143.2 ENSMUST00000103143.3 ENSMUST00000103143.4 ENSMUST00000103143.5 ENSMUST00000103143.6 ENSMUST00000103143.7 ENSMUST00000103143.8 ENSMUST00000103143.9 FXL20_MOUSE Fbl2 NM_028149 Q3UMN2 Q571F7 Q8BZ95 Q9CZV8 uc007lfm.1 uc007lfm.2 uc007lfm.3 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Isoform 3 regulates neural transmission by binding and ubiquitinating RIMS1, a modulator of presynaptic plasticity. Interacts with SKP1 and CUL1. Q9CZV8; Q99NE5: Rims1; NbExp=4; IntAct=EBI-1551033, EBI-775541; Cytoplasm Note=Isoform 3 is present at the presynaptic membrane. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9CZV8-1; Sequence=Displayed; Name=2; IsoId=Q9CZV8-4; Sequence=VSP_038354; Name=3; Synonyms=Scrapper; IsoId=Q9CZV8-3; Sequence=VSP_030770; Highly expressed in brain. Altered electrophysiological synaptic activity, with increased frequency of miniature excitatory postsynaptic currents. Sequence=BAC29349.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAD90157.1; Type=Erroneous initiation; Evidence=; behavioral fear response protein binding cytoplasm ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process synapse presynapse glutamatergic synapse regulation of protein catabolic process at presynapse, modulating synaptic transmission regulation of synaptic vesicle exocytosis ubiquitin-protein transferase activity uc007lfm.1 uc007lfm.2 uc007lfm.3 
ENSMUST00000103145.11 E2f1 ENSMUST00000103145.11 E2F transcription factor 1, transcript variant 1 (from RefSeq NM_007891.5) E2F1_MOUSE E2f1 ENSMUST00000103145.1 ENSMUST00000103145.10 ENSMUST00000103145.2 ENSMUST00000103145.3 ENSMUST00000103145.4 ENSMUST00000103145.5 ENSMUST00000103145.6 ENSMUST00000103145.7 ENSMUST00000103145.8 ENSMUST00000103145.9 NM_007891 Q61501 Q80VZ3 uc008njk.1 uc008njk.2 uc008njk.3 uc008njk.4 Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:11672531, PubMed:20176812, PubMed:9674698). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (By similarity). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (By similarity). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:9674698). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:11672531, PubMed:20176812). Directly activates transcription of PEG10 (By similarity). Positively regulates transcription of RRP1B (By similarity). BIRC2/c-IAP1 stimulates its transcriptional activity. Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F1 complex binds specifically hypophosphorylated retinoblastoma protein RB1 (PubMed:8336704). During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A. Interacts with TRIM28; the interaction inhibits E2F1 acetylation through recruiting HDAC1 and represses its transcriptional activity. Interaction with KAT2B; the interaction acetylates E2F1 enhancing its DNA-binding and transcriptional activity. Interacts with BIRC2/c-IAP1 (via BIR domains). The complex TFDP1:E2F1 interacts with CEBPA; the interaction prevents CEBPA binding to target genes promoters and represses its transcriptional activity. Interacts with RRP1B (By similarity). Interacts with HCFC1 (By similarity). Interacts with KMT2E; the interaction is probably indirect and is mediated via HCFC1 (By similarity). Interacts with DCAF5 and L3MBTL3; the interaction requires methylation at Lys-180 and is necessary to target E2F1 for ubiquitination by the CRL4-DCAF5 E3 ubiquitin ligase complex (By similarity). Q61501; P25233: Ndn; NbExp=6; IntAct=EBI-1025536, EBI-1801080; Q61501; Q9CPR8: Nsmce3; NbExp=5; IntAct=EBI-1025536, EBI-5529102; Nucleus In the developing nervous system, first detected in the neural tube at 9.5 dpc. By 10.5 dpc, levels increase throughout the brain, with highest levels in the hindbrain and in the spinal cord, expressed only in the rostral half. By 11.5 dpc, expression found throughout the brain and spinal cord. From 12.5 dpc, expression restricted to the ventricular regions of the brain, peaks at 13.5 dpc and declines thereafter. Only weak expression in the developing spinal cord from 11.5-16.5 dpc. In the developing retina, expression is confined to the undifferentiated retinoblastic cell layer. In other developing tissues, E2F1 is expressed in kidney, lung, liver hepatocytes, heart and thymus. Highest levels in liver. Absent in choroid plexus. Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis. Phosphorylation at Ser-396 by GSK3B promotes interaction with USP11, leading to its deubiquitination and stabilization. Ubiquitinated via 'Lys-63'-linked ubiquitin, leading to its degradation. Deubiquitinated by USP11 follwong phosphorylation by GSK3B, promoting its stability. Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation. Acetylated by P/CAF/KAT2B (By similarity). Methylation at Lys-180 by SETD7 promotes E2F1 ubiquitin-dependent proteasomal degradation. Belongs to the E2F/DP family. DNA damage checkpoint negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm centrosome transcription, DNA-templated regulation of transcription, DNA-templated apoptotic process cell cycle spermatogenesis transcription factor binding intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of gene expression protein kinase binding forebrain development macromolecular complex Rb-E2F complex positive regulation of apoptotic process anoikis negative regulation of DNA binding sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity positive regulation of fibroblast proliferation mRNA stabilization regulation of cell cycle positive regulation of glial cell proliferation negative regulation of fat cell proliferation cellular response to fatty acid cellular response to hypoxia cellular response to xenobiotic stimulus negative regulation of transcription involved in G1/S transition of mitotic cell cycle intrinsic apoptotic signaling pathway by p53 class mediator RNA polymerase II transcription factor complex lens fiber cell apoptotic process cellular response to nerve growth factor stimulus regulation of G1/S transition of mitotic cell cycle uc008njk.1 uc008njk.2 uc008njk.3 uc008njk.4 
ENSMUST00000103146.5 Rpl23 ENSMUST00000103146.5 ribosomal protein L23 (from RefSeq NM_022891.3) ENSMUST00000103146.1 ENSMUST00000103146.2 ENSMUST00000103146.3 ENSMUST00000103146.4 NM_022891 P23131 P24048 P62830 Q29246 Q3THU4 Q9CZE6 Q9DCQ4 RL23_MOUSE uc007leu.1 uc007leu.2 uc007leu.3 uc007leu.4 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. P62830; P23804: Mdm2; NbExp=2; IntAct=EBI-2365752, EBI-641788; Cytoplasm Belongs to the universal ribosomal protein uL14 family. negative regulation of transcription from RNA polymerase II promoter transcription coactivator binding structural constituent of ribosome protein binding nucleoplasm nucleolus cytoplasm ribosome translation positive regulation of cell proliferation positive regulation of gene expression postsynaptic density cytosolic large ribosomal subunit cytosolic ribosome ubiquitin protein ligase binding protein-DNA complex disassembly macromolecular complex protein stabilization large ribosomal subunit rRNA binding negative regulation of cell cycle arrest positive regulation of cell cycle arrest cellular response to actinomycin D positive regulation of signal transduction by p53 class mediator negative regulation of ubiquitin protein ligase activity ubiquitin ligase inhibitor activity negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc007leu.1 uc007leu.2 uc007leu.3 uc007leu.4 
ENSMUST00000103147.5 Psmb3 ENSMUST00000103147.5 proteasome (prosome, macropain) subunit, beta type 3 (from RefSeq NM_011971.4) ENSMUST00000103147.1 ENSMUST00000103147.2 ENSMUST00000103147.3 ENSMUST00000103147.4 NM_011971 PSB3_MOUSE Q9R1P1 uc007lep.1 uc007lep.2 uc007lep.3 Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Cytoplasm Nucleus Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. Detected in liver (at protein level). Belongs to the peptidase T1B family. proteasome complex endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteolysis peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, beta-subunit complex protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process uc007lep.1 uc007lep.2 uc007lep.3 
ENSMUST00000103152.11 Cdk5rap3 ENSMUST00000103152.11 CDK5 regulatory subunit associated protein 3, transcript variant 1 (from RefSeq NM_030248.2) CK5P3_MOUSE Cdk5rap3 ENSMUST00000103152.1 ENSMUST00000103152.10 ENSMUST00000103152.2 ENSMUST00000103152.3 ENSMUST00000103152.4 ENSMUST00000103152.5 ENSMUST00000103152.6 ENSMUST00000103152.7 ENSMUST00000103152.8 ENSMUST00000103152.9 NM_030248 Q3UE41 Q99LM2 uc007lcv.1 uc007lcv.2 uc007lcv.3 uc007lcv.4 Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (PubMed:30635284). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (By similarity). Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (By similarity). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (By similarity). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (By similarity). May also play a role in the rupture of the nuclear envelope during apoptosis (By similarity). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (By similarity). Required for liver development (PubMed:30635284). Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (By similarity). Interacts with RELA (By similarity). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (By similarity). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (By similarity). Interacts with UFL1; the interaction is direct (PubMed:21494687, PubMed:30635284). Interaction with UFL1 anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (By similarity). Interacts with DDRGK1 (By similarity). Interacts with MAPK14 (By similarity). Interacts with CCNB1 (By similarity). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (By similarity). Nucleus Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes and associates with microtubules. Widely expressed with higher expression in secretory tissues. Predominantly expressed in hepatocytes during liver development. May be phosphorylated by CDK5. May be ufmylated. Ubiquitinated. Probably triggers proteasomal degradation and is negatively regulated by UFL1. Cleaved by caspases early during apoptosis, the resulting peptides may play a role in rupture of the nuclear envelope. Prenatal lethality, probably caused by severe liver hypoplasia (PubMed:30635284). 16.5 dpc mutant embryos also show defects in definitive erythropoiesis (PubMed:30635284). Conditional knockout mice lacking Cdk5rap3 in hepatocytes causes lethality after weaning -specific Cdk5rap3 display liver hypoplasia and die after weaning (PubMed:30635284). Belongs to the CDK5RAP3 family. regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of protein phosphorylation protein binding cellular_component nucleus nucleolus cytoplasm centrosome microtubule organizing center cytosol cytoskeleton microtubule mitotic G2 DNA damage checkpoint regulation of mitotic cell cycle cell proliferation regulation of phosphatase activity protein kinase binding apoptotic nuclear changes cyclin binding endoplasmic reticulum unfolded protein response positive regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity macromolecular complex negative regulation of MAP kinase activity negative regulation of protein kinase activity by regulation of protein phosphorylation ubiquitin-like protein ligase binding mitotic G2/M transition checkpoint macromolecular complex binding positive regulation of transcription from RNA polymerase II promoter mitogen-activated protein kinase binding NF-kappaB binding protein ufmylation negative regulation of protein serine/threonine kinase activity MDM2/MDM4 family protein binding positive regulation of protein localization to nucleus positive regulation of signal transduction by p53 class mediator negative regulation of cellular protein catabolic process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc007lcv.1 uc007lcv.2 uc007lcv.3 uc007lcv.4 
ENSMUST00000103154.11 Skap1 ENSMUST00000103154.11 src family associated phosphoprotein 1, transcript variant 1 (from RefSeq NM_001033186.3) ENSMUST00000103154.1 ENSMUST00000103154.10 ENSMUST00000103154.2 ENSMUST00000103154.3 ENSMUST00000103154.4 ENSMUST00000103154.5 ENSMUST00000103154.6 ENSMUST00000103154.7 ENSMUST00000103154.8 ENSMUST00000103154.9 NM_001033186 Q3TE54 Q3UUT7 Q3UUV5 Q3UUX6 SKAP1_MOUSE Scap1 uc007lcf.1 uc007lcf.2 uc007lcf.3 uc007lcf.4 Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway (By similarity). Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493). Homodimer (By similarity). Interacts with FYN (PubMed:12681493). Interacts with PTPRC (By similarity). Interacts with GRB2 when phosphorylated on Tyr-268 (By similarity). Interacts with FYB1, which is required for SKAP2 protein stability (By similarity). Part of a complex consisting of SKAP1, FYB1 and CLNK (PubMed:12681493). Interacts with RASGRP1 (By similarity). Interacts with FYB2 (By similarity). Cytoplasm Nucleus Cell membrane Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3UUV5-1; Sequence=Displayed; Name=2; IsoId=Q3UUV5-2; Sequence=VSP_022180, VSP_022181, VSP_022182; Name=3; IsoId=Q3UUV5-3; Sequence=VSP_022181, VSP_022183; Name=4; IsoId=Q3UUV5-4; Sequence=VSP_022181; The SH3 domain interacts with FYB1. Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-268 is required for GRB2 interaction (By similarity). Phosphorylation by FYN on Tyr-291 abolishes interaction with FYB1. Tyr-237 is dephosphorylated by PTPRC (By similarity). Belongs to the SKAP family. microtubule cytoskeleton organization ruffle immunological synapse positive regulation of cell-matrix adhesion adaptive immune response immune system process positive regulation of adaptive immune response protein binding nucleus cytoplasm cytosol plasma membrane cell-cell junction membrane cell migration protein kinase binding protein phosphatase binding positive regulation of integrin activation positive regulation of cell-cell adhesion mediated by integrin positive regulation of heterotypic cell-cell adhesion microtubule plus-end T cell receptor complex SH2 domain binding protein homodimerization activity plasma membrane raft macromolecular complex binding positive regulation of cell adhesion positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter T cell receptor signaling pathway microtubule plus-end binding cellular response to epidermal growth factor stimulus protein localization to plasma membrane positive regulation of leukocyte cell-cell adhesion uc007lcf.1 uc007lcf.2 uc007lcf.3 uc007lcf.4 
ENSMUST00000103157.10 Gip ENSMUST00000103157.10 gastric inhibitory polypeptide (from RefSeq NM_008119.2) ENSMUST00000103157.1 ENSMUST00000103157.2 ENSMUST00000103157.3 ENSMUST00000103157.4 ENSMUST00000103157.5 ENSMUST00000103157.6 ENSMUST00000103157.7 ENSMUST00000103157.8 ENSMUST00000103157.9 GIP_MOUSE NM_008119 P48756 Q9D887 uc007lba.1 uc007lba.2 uc007lba.3 This gene encodes an incretin hormone that belongs to the glucagon superfamily. The encoded preproprotein undergoes proteolytic processing to generate mature peptides that function as potent stimulators of insulin secretion and inhibit gastric acid secretion. Transgenic mice overexpressing the encoded protein exhibit a significant increase in the expression of markers of bone formation, a decrease in the expression of markers of bone resorption and, an increase in the bone mass. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK008308.1, BY708239.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. Secreted. Belongs to the glucagon family. receptor binding hormone activity extracellular region extracellular space cytoplasm signal transduction female pregnancy memory adult locomotory behavior response to carbohydrate response to glucose response to selenium ion response to acidic pH positive regulation of glucose transport response to organic cyclic compound sensory perception of pain endocrine pancreas development response to nutrient levels positive regulation of insulin secretion response to lipid secretory granule lumen exploration behavior regulation of fatty acid biosynthetic process response to drug response to starvation neuronal cell body response to amino acid response to peptide hormone positive regulation of cAMP-mediated signaling response to axon injury regulation of insulin secretion positive regulation of synaptic transmission digestive system development long-term synaptic potentiation positive regulation of glucagon secretion triglyceride homeostasis uc007lba.1 uc007lba.2 uc007lba.3 
ENSMUST00000103162.8 Sgca ENSMUST00000103162.8 sarcoglycan, alpha (dystrophin-associated glycoprotein) (from RefSeq NM_009161.4) ENSMUST00000103162.1 ENSMUST00000103162.2 ENSMUST00000103162.3 ENSMUST00000103162.4 ENSMUST00000103162.5 ENSMUST00000103162.6 ENSMUST00000103162.7 NM_009161 O35311 O88490 P82350 SGCA_MOUSE uc007kzo.1 uc007kzo.2 uc007kzo.3 uc007kzo.4 uc007kzo.5 This gene encodes a member of the sarcoglycan alpha/epsilon family of transmembrane proteins. The encoded protein is part of the dystrophin-glycoprotein complex which links the extracellular matrix to the cytoskeleton in muscle fibers. Disruption of this gene results in progressive muscular dystrophy and is associated with the development of embryonal rhabdomysarcoma. [provided by RefSeq, Dec 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. The combination of the 5' and 3' non-coding exons is inferred from available partial transcript data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC060287.1, AF019564.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00849387 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans. Interacts with the syntrophin SNTA1. Cell membrane, sarcolemma ; Single-pass type I membrane protein Cytoplasm, cytoskeleton Striated muscle, both skeletal and cardiac. In the embryo, expression begins at day 14 and coincides with the onset of primary myogenesis. Belongs to the sarcoglycan alpha/epsilon family. calcium ion binding cytoplasm cytoskeleton plasma membrane integral component of plasma membrane cell-cell junction response to denervation involved in regulation of muscle adaptation dystroglycan complex sarcoglycan complex membrane integral component of membrane sarcolemma skeletal muscle tissue regeneration membrane raft membrane organization uc007kzo.1 uc007kzo.2 uc007kzo.3 uc007kzo.4 uc007kzo.5 
ENSMUST00000103164.4 Acsf2 ENSMUST00000103164.4 acyl-CoA synthetase family member 2 (from RefSeq NM_153807.2) ACSF2_MOUSE Acsf2 ENSMUST00000103164.1 ENSMUST00000103164.2 ENSMUST00000103164.3 NM_153807 Q3TDU9 Q3U5G9 Q8VCW8 uc007kzc.1 uc007kzc.2 uc007kzc.3 Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation. Reaction=a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:48340, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:59558, ChEBI:CHEBI:90546, ChEBI:CHEBI:456215; EC=6.2.1.2; Evidence=; Reaction=ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA; Xref=Rhea:RHEA:33631, ChEBI:CHEBI:25646, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:456215; Evidence=; Mitochondrion Belongs to the ATP-dependent AMP-binding enzyme family. nucleotide binding molecular_function catalytic activity ATP binding mitochondrion lipid metabolic process fatty acid metabolic process biological_process ligase activity medium-chain fatty acid-CoA ligase activity butyrate-CoA ligase activity uc007kzc.1 uc007kzc.2 uc007kzc.3 
ENSMUST00000103172.4 Dstn ENSMUST00000103172.4 destrin (from RefSeq NM_019771.2) DEST_MOUSE Dsn ENSMUST00000103172.1 ENSMUST00000103172.2 ENSMUST00000103172.3 NM_019771 Q9R0P5 Sid23 uc008mqi.1 uc008mqi.2 uc008mqi.3 uc008mqi.4 Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. Widely expressed. Not found in skeletal muscle. In 10.5 dpc embryo somites is expressed in a superficial patch of cells (adaxial region). ISGylated. Belongs to the actin-binding proteins ADF family. actin binding cytoplasm actin cytoskeleton actin filament depolymerization actin filament fragmentation positive regulation of actin filament depolymerization cortical actin cytoskeleton actin filament severing actin filament binding uc008mqi.1 uc008mqi.2 uc008mqi.3 uc008mqi.4 
ENSMUST00000103173.10 Tnfrsf18 ENSMUST00000103173.10 tumor necrosis factor receptor superfamily, member 18, transcript variant 1 (from RefSeq NM_009400.3) ENSMUST00000103173.1 ENSMUST00000103173.2 ENSMUST00000103173.3 ENSMUST00000103173.4 ENSMUST00000103173.5 ENSMUST00000103173.6 ENSMUST00000103173.7 ENSMUST00000103173.8 ENSMUST00000103173.9 NM_009400 Q540M6 Q540M6_MOUSE Tnfrsf18 uc008wfx.1 uc008wfx.2 uc008wfx.3 tumor necrosis factor-activated receptor activity integral component of plasma membrane membrane integral component of membrane tumor necrosis factor-mediated signaling pathway negative regulation of apoptotic process uc008wfx.1 uc008wfx.2 uc008wfx.3 
ENSMUST00000103176.10 Mib2 ENSMUST00000103176.10 mindbomb E3 ubiquitin protein ligase 2, transcript variant 2 (from RefSeq NM_145124.3) A2A9P9 ENSMUST00000103176.1 ENSMUST00000103176.2 ENSMUST00000103176.3 ENSMUST00000103176.4 ENSMUST00000103176.5 ENSMUST00000103176.6 ENSMUST00000103176.7 ENSMUST00000103176.8 ENSMUST00000103176.9 MIB2_MOUSE NM_145124 Q52QU8 Q6PEF6 Q8C1N7 Q8R516 Q8VIB4 Skd uc008wef.1 uc008wef.2 uc008wef.3 uc008wef.4 E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with actin monomer. Cytoplasm Endosome Note=Colocalizes with endosomal compartments. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R516-1; Sequence=Displayed; Name=2; IsoId=Q8R516-2; Sequence=VSP_014397, VSP_014400, VSP_014401; Name=3; IsoId=Q8R516-3; Sequence=VSP_014398, VSP_014399; Highly expressed in brain, heart, liver and kidney. Highly expressed in neonate and adult, but only slightly in embryos. In 10.5 dpc embryos, it is weakly expressed in the tail bud and limb buds. Expressed in the same pattern than MIB1 in the skin and intestine at postnatal day 1 (P1) and in the hair follicle in the skin in the adult. Ubiquitinated. Possibly via autoubiquitination. [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=BAB79447.1; Type=Frameshift; Evidence=; Sequence=BAB86856.1; Type=Frameshift; Evidence=; ubiquitin ligase complex actin binding ubiquitin-protein transferase activity cytoplasm endosome early endosome Notch signaling pathway zinc ion binding protein ubiquitination transferase activity metal ion binding ubiquitin protein ligase activity uc008wef.1 uc008wef.2 uc008wef.3 uc008wef.4 
ENSMUST00000103177.10 Lpo ENSMUST00000103177.10 lactoperoxidase (from RefSeq NM_080420.3) ENSMUST00000103177.1 ENSMUST00000103177.2 ENSMUST00000103177.3 ENSMUST00000103177.4 ENSMUST00000103177.5 ENSMUST00000103177.6 ENSMUST00000103177.7 ENSMUST00000103177.8 ENSMUST00000103177.9 Lpo NM_080420 PERL_MOUSE Q5SW46 uc007kus.1 uc007kus.2 uc007kus.3 uc007kus.4 Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (By similarity). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity). Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism (By similarity). May be implicated in airway host defense against infection (By similarity). May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (PubMed:34127712). Reaction=2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O; Xref=Rhea:RHEA:56136, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:139520, ChEBI:CHEBI:139521; EC=1.11.1.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56137; Evidence=; Reaction=H(+) + H2O2 + thiocyanate = H2O + hypothiocyanous acid; Xref=Rhea:RHEA:69416, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:18022, ChEBI:CHEBI:133907; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69417; Evidence=; Reaction=H2O2 + iodide = H2O + hypoiodite; Xref=Rhea:RHEA:69420, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:16382, ChEBI:CHEBI:29232; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69421; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per heterodimer. Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer. ; Secreted Cytoplasm Note=Expressed in the cytoplasm in intestinal epithelial cells. Expressed in the colon, including colonocytes and mucin-containing goblet cells (PubMed:22343415, PubMed:34127712). Not detected in the ileum (PubMed:22343415). Knockout mice exhibit inflammation and lesions in the cardiovascular, respiratory, digestive or excretory systems, neuropathology, and tumors, with high incidence. Thiocyanate (SCN(-)) and hypothiocyanite (OSCN(-)) are bound in the distal heme cavity. The iodide ion (I(-)) occupies a position which is stabilized by the interactions with heme moiety, His- 224, Arg-370 and Glu-373. Hydrogen peroxide is held between the heme iron and His-224. Belongs to the peroxidase family. detection of chemical stimulus involved in sensory perception of bitter taste peroxidase activity extracellular space cytoplasm response to oxidative stress basolateral plasma membrane thiocyanate metabolic process heme binding thiocyanate peroxidase activity defense response to bacterium oxidation-reduction process cellular oxidant detoxification uc007kus.1 uc007kus.2 uc007kus.3 uc007kus.4 
ENSMUST00000103179.10 Mtmr4 ENSMUST00000103179.10 myotubularin related protein 4, transcript variant 1 (from RefSeq NM_133215.2) ENSMUST00000103179.1 ENSMUST00000103179.2 ENSMUST00000103179.3 ENSMUST00000103179.4 ENSMUST00000103179.5 ENSMUST00000103179.6 ENSMUST00000103179.7 ENSMUST00000103179.8 ENSMUST00000103179.9 MTMR4_MOUSE NM_133215 Q5ND06 Q5ND08 Q91XS1 uc007ktz.1 uc007ktz.2 uc007ktz.3 Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para- nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5- trisphosphate (PIP3) (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Cytoplasm Membrane ; Peripheral membrane protein Note=Localized to perinuclear region. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91XS1-1; Sequence=Displayed; Name=2; IsoId=Q91XS1-2; Sequence=VSP_028126; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity cytoplasm endosome protein dephosphorylation transforming growth factor beta receptor signaling pathway response to denervation involved in regulation of muscle adaptation membrane dephosphorylation hydrolase activity phosphatase activity protein phosphatase binding peptidyl-tyrosine dephosphorylation metal ion binding regulation of phosphatidylinositol dephosphorylation uc007ktz.1 uc007ktz.2 uc007ktz.3 
ENSMUST00000103180.4 Pex10 ENSMUST00000103180.4 peroxisomal biogenesis factor 10 (from RefSeq NM_001042407.1) B1AUE5 ENSMUST00000103180.1 ENSMUST00000103180.2 ENSMUST00000103180.3 NM_001042407 PEX10_MOUSE uc008wcs.1 uc008wcs.2 uc008wcs.3 E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity). When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; The E3 ubiquitin-protein ligase activity is stimulated by PEX12. Protein modification; protein ubiquitination. Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12. Interacts with PEX19. Peroxisome membrane ; Multi-pass membrane protein The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex. Belongs to the pex2/pex10/pex12 family. peroxisome peroxisomal membrane integral component of peroxisomal membrane peroxisome organization protein C-terminus binding membrane protein import into peroxisome matrix metal ion binding uc008wcs.1 uc008wcs.2 uc008wcs.3 
ENSMUST00000103181.11 Cds2 ENSMUST00000103181.11 CDP-diacylglycerol synthase 2, transcript variant 1 (from RefSeq NM_138651.7) CDS2_MOUSE Cds2 ENSMUST00000103181.1 ENSMUST00000103181.10 ENSMUST00000103181.2 ENSMUST00000103181.3 ENSMUST00000103181.4 ENSMUST00000103181.5 ENSMUST00000103181.6 ENSMUST00000103181.7 ENSMUST00000103181.8 ENSMUST00000103181.9 NM_138651 Q3TMD1 Q6NSU1 Q99L43 uc008mmo.1 uc008mmo.2 uc008mmo.3 Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (By similarity). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (By similarity). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540). Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2- diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16230; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45648, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77091, ChEBI:CHEBI:85349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45649; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)- sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45660, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77098, ChEBI:CHEBI:85352; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45661; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45652, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:72864, ChEBI:CHEBI:85350; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45653; Evidence=; Reaction=1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3- cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45656, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77126, ChEBI:CHEBI:85351; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45657; Evidence=; Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45664, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:74560, ChEBI:CHEBI:85353; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45665; Evidence=; Reaction=1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2- (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'- diphosphate + diphosphate; Xref=Rhea:RHEA:45668, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77130, ChEBI:CHEBI:85354; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45669; Evidence=; Reaction=1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'- diphosphate + diphosphate; Xref=Rhea:RHEA:45672, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77128, ChEBI:CHEBI:85355; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45673; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45676, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:74546, ChEBI:CHEBI:85356; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45677; Evidence=; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 3/3. Homodimer. Endoplasmic reticulum membrane ; Multi-pass membrane protein Ubiquitous. Expressed in the ganglion cell layer and inner nuclear layer of the retina. Belongs to the CDS family. phosphatidate cytidylyltransferase activity mitochondrion mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phototransduction phospholipid biosynthetic process membrane integral component of membrane CDP-diacylglycerol biosynthetic process transferase activity transferase activity, transferring phosphorus-containing groups nucleotidyltransferase activity glycosylation uc008mmo.1 uc008mmo.2 uc008mmo.3 
ENSMUST00000103184.4 Adra1d ENSMUST00000103184.4 adrenergic receptor, alpha 1d (from RefSeq NM_013460.5) A2ANQ2 A2ANQ2_MOUSE Adra1d ENSMUST00000103184.1 ENSMUST00000103184.2 ENSMUST00000103184.3 NM_013460 uc008mlu.1 uc008mlu.2 uc008mlu.3 This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. Interacts with FLNA (via filamin repeat 21); increases PKA- mediated phosphorylation of FLNA. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity adrenergic receptor activity alpha1-adrenergic receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane identical protein binding adrenergic receptor signaling pathway uc008mlu.1 uc008mlu.2 uc008mlu.3 
ENSMUST00000103186.11 Cltc ENSMUST00000103186.11 clathrin heavy chain, transcript variant 1 (from RefSeq NM_001356393.1) CLH1_MOUSE ENSMUST00000103186.1 ENSMUST00000103186.10 ENSMUST00000103186.2 ENSMUST00000103186.3 ENSMUST00000103186.4 ENSMUST00000103186.5 ENSMUST00000103186.6 ENSMUST00000103186.7 ENSMUST00000103186.8 ENSMUST00000103186.9 NM_001356393 Q68FD5 uc007kta.1 uc007kta.2 uc007kta.3 Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch- TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat (By similarity). In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium (By similarity). Interacts with HIP1 (By similarity). Interacts with DENND1A, DENND1B and DENND1C (By similarity). Interacts with ERBB2 (By similarity). Interacts with FKBP6 (By similarity). Interacts with OCRL (PubMed:20133602). Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions; TACC3 and CLTC are proposed to form a composite microtubule interaction surface (By similarity). Plays a role in early autophagosome formation (By similarity). Interacts with ATG16L1 (via N- terminus) (By similarity). Interacts with RFTN1; the interaction occurs in response to pathogens (By similarity). Interacts with USP2 isoform 2 (PubMed:26756164). Interacts with TMEM106B (via N-terminus) (By similarity). Q68FD5; Q01968: OCRL; Xeno; NbExp=2; IntAct=EBI-769168, EBI-6148898; Q68FD5; Q15637: SF1; Xeno; NbExp=3; IntAct=EBI-769168, EBI-744603; Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane, coated pit ; Peripheral membrane protein ; Cytoplasmic side Melanosome Cytoplasm, cytoskeleton, spindle Note=Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch- TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles. The N-terminal seven-bladed beta-propeller is formed by WD40- like repeats, and projects inward from the polyhedral outer clathrin coat. It constitutes a major protein-protein interaction node (By similarity). Belongs to the clathrin heavy chain family. mitotic cell cycle double-stranded RNA binding structural molecule activity protein binding cytoplasm mitochondrion lysosome endosome spindle cytosol cytoskeleton clathrin-coated pit intracellular protein transport receptor-mediated endocytosis autophagy Golgi organization cell cycle protein C-terminus binding membrane vesicle-mediated transport protein kinase binding membrane coat clathrin coat clathrin coat of trans-Golgi network vesicle clathrin coat of coated pit clathrin-coated vesicle T-tubule ankyrin binding cytoplasmic vesicle membrane heat shock protein binding cytoplasmic vesicle Myb complex receptor internalization clathrin light chain binding macromolecular complex transferrin transport retrograde transport, endosome to Golgi peptide binding sarcolemma melanosome myelin sheath intracellular membrane-bounded organelle clathrin-coated endocytic vesicle clathrin coat assembly synaptic vesicle endocytosis low-density lipoprotein particle receptor binding cell division regulation of mitotic spindle organization clathrin complex clathrin-dependent endocytosis mitotic spindle mitotic spindle assembly disordered domain specific binding presynaptic endocytic zone membrane extrinsic component of synaptic vesicle membrane negative regulation of hyaluronan biosynthetic process negative regulation of protein localization to plasma membrane ubiquitin-specific protease binding mitotic spindle microtubule uc007kta.1 uc007kta.2 uc007kta.3 
ENSMUST00000103188.10 Adissp ENSMUST00000103188.10 adipose secreted signaling protein, transcript variant 2 (from RefSeq NM_026091.3) ADSSP_MOUSE Adissp ENSMUST00000103188.1 ENSMUST00000103188.2 ENSMUST00000103188.3 ENSMUST00000103188.4 ENSMUST00000103188.5 ENSMUST00000103188.6 ENSMUST00000103188.7 ENSMUST00000103188.8 ENSMUST00000103188.9 NM_026091 Q9CVT3 Q9D1K7 uc008mks.1 uc008mks.2 uc008mks.3 uc008mks.4 Adipocyte-secreted protein (adipokine) that acts as a key regulator for white adipose tissue (WAT) thermogenesis and glucose homeostasis at least in part through activation of protein kinase A (PKA). Secreted Expression is adipose-specific and highly brown adipose tissue-enriched. Adipose-specific Adissp knockout mice are defective in WAT browning, and are susceptible to high fat diet-induced obesity and hyperglycemia. Belongs to the ADISSP family. molecular_function cellular_component biological_process uc008mks.1 uc008mks.2 uc008mks.3 uc008mks.4 
ENSMUST00000103193.5 Itpa ENSMUST00000103193.5 inosine triphosphatase (nucleoside triphosphate pyrophosphatase), transcript variant 1 (from RefSeq NM_025922.3) ENSMUST00000103193.1 ENSMUST00000103193.2 ENSMUST00000103193.3 ENSMUST00000103193.4 ITPA_MOUSE NM_025922 Q8R0Q8 Q9D892 uc008mju.1 uc008mju.2 uc008mju.3 Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- phosphate + diphosphate + H(+); Xref=Rhea:RHEA:23996, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.9; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23997; Evidence= Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'- deoxyribonucleoside 5'-phosphate + diphosphate + H(+); Xref=Rhea:RHEA:44644, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:65317; EC=3.6.1.9; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44645; Evidence= Reaction=H2O + ITP = diphosphate + H(+) + IMP; Xref=Rhea:RHEA:29399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:58053, ChEBI:CHEBI:61402; EC=3.6.1.9; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29400; Evidence= Reaction=dITP + H2O = dIMP + diphosphate + H(+); Xref=Rhea:RHEA:28342, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61194, ChEBI:CHEBI:61382; EC=3.6.1.9; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28343; Evidence= Reaction=H2O + XTP = diphosphate + H(+) + XMP; Xref=Rhea:RHEA:28610, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:57464, ChEBI:CHEBI:61314; EC=3.6.1.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28611; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+). ; Kinetic parameters: KM=24.9 uM for dITP ; KM=38.4 uM for dHAPTP ; KM=667 uM for dGTP ; Note=kcat is 84 sec(-1) with dITP as substrate (PubMed:17090528). kcat is 115 sec(-1) with dHAPTP as substrate (PubMed:17090528). kcat is 12.4 sec(-1) with dGTP as substrate (PubMed:17090528). ; Homodimer. Cytoplasm Pups die about 2 weeks after birth with growth retardation and heart failure. Accumulates ITP in erythrocytes. Accumulates inosine in RNA and deoxyinosine in DNA. Belongs to the HAM1 NTPase family. nucleotide binding nucleotide diphosphatase activity cytoplasm cytosol ITP catabolic process nucleotide metabolic process nucleoside triphosphate catabolic process deoxyribonucleoside triphosphate catabolic process hydrolase activity NADH pyrophosphatase activity dITP diphosphatase activity identical protein binding metal ion binding nucleoside-triphosphate diphosphatase activity chromosome organization uc008mju.1 uc008mju.2 uc008mju.3 
ENSMUST00000103194.10 Car4 ENSMUST00000103194.10 carbonic anhydrase 4 (from RefSeq NM_007607.2) CAH4_MOUSE Ca4 ENSMUST00000103194.1 ENSMUST00000103194.2 ENSMUST00000103194.3 ENSMUST00000103194.4 ENSMUST00000103194.5 ENSMUST00000103194.6 ENSMUST00000103194.7 ENSMUST00000103194.8 ENSMUST00000103194.9 NM_007607 Q64444 uc007krg.1 uc007krg.2 uc007krg.3 uc007krg.4 Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid. Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10749; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:10750; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Inhibited by acetazolamide. Interacts with SLC4A4. Q64444; O88343: Slc4a4; NbExp=2; IntAct=EBI-6859308, EBI-771342; Cell membrane ; Lipid-anchor, GPI-anchor Belongs to the alpha-carbonic anhydrase family. carbonate dehydratase activity protein binding rough endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus trans-Golgi network plasma membrane regulation of pH zinc ion binding cell surface carbon dioxide transport bicarbonate transport membrane apical plasma membrane sarcoplasmic reticulum lyase activity transport vesicle membrane secretory granule membrane anchored component of membrane anchored component of external side of plasma membrane brush border membrane sarcolemma anchored component of plasma membrane metal ion binding perinuclear region of cytoplasm extracellular exosome uc007krg.1 uc007krg.2 uc007krg.3 uc007krg.4 
ENSMUST00000103195.5 Znhit3 ENSMUST00000103195.5 zinc finger, HIT type 3, transcript variant 2 (from RefSeq NM_001359182.1) ENSMUST00000103195.1 ENSMUST00000103195.2 ENSMUST00000103195.3 ENSMUST00000103195.4 NM_001359182 Q9CQK1 Trip3 ZNHI3_MOUSE uc007kre.1 uc007kre.2 uc007kre.3 Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR) (By similarity). Requires the presence of thyroid hormone for its interaction (By similarity). Interacts with NUFIP1 (By similarity). Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP (By similarity). Cytoplasm Nucleus Expressed in the cerebellum. Detected in proliferating fetal granule cell precursors at embryonic day 16.5, in proliferating and post-mitotic granule cells at postnatal days 3 and 10. Expression in cerebellar Purkinje cells is strong at postnatal days 10 and 21. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) box C/D snoRNP assembly molecular_function nucleus cytoplasm metal ion binding snoRNA localization pre-snoRNP complex uc007kre.1 uc007kre.2 uc007kre.3 
ENSMUST00000103197.5 Nol9 ENSMUST00000103197.5 nucleolar protein 9, transcript variant 2 (from RefSeq NM_028727.3) A0PJC7 B1AS65 ENSMUST00000103197.1 ENSMUST00000103197.2 ENSMUST00000103197.3 ENSMUST00000103197.4 NM_028727 NOL9_MOUSE Nol9 Q05A31 Q3TZX8 Q8BQE1 Q8C8L5 Q8C9A8 Q9D678 uc008vzf.1 uc008vzf.2 uc008vzf.3 uc008vzf.4 uc008vzf.5 Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (By similarity). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (By similarity). Reaction=a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+); Xref=Rhea:RHEA:15669, Rhea:RHEA-COMP:13180, Rhea:RHEA-COMP:13184, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:136412, ChEBI:CHEBI:136416, ChEBI:CHEBI:456216; EC=2.7.1.78; Evidence=; Reaction=a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'- monophospho-ribonucleoside-RNA + ADP + H(+); Xref=Rhea:RHEA:54580, Rhea:RHEA-COMP:13935, Rhea:RHEA-COMP:13936, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:138282, ChEBI:CHEBI:138284, ChEBI:CHEBI:456216; EC=2.7.1.78; Evidence=; Interacts with PELP1, WDR18 and SENP3 (PubMed:22872859). Interacts with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex (By similarity). Nucleus, nucleolus Nucleus Note=Colocalizes with pre-60S rRNP particles. Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q3TZX8-1; Sequence=Displayed; Name=2 ; IsoId=Q3TZX8-2; Sequence=VSP_053056, VSP_053057; Name=3 ; IsoId=Q3TZX8-3; Sequence=VSP_053058, VSP_053059; Belongs to the Clp1 family. NOL9/GRC3 subfamily. Sequence=AAH24877.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; nucleotide binding cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of 5.8S rRNA RNA binding ATP binding nucleus nucleolus rRNA processing kinase activity phosphorylation transferase activity intermediate filament cytoskeleton polynucleotide 5'-hydroxyl-kinase activity uc008vzf.1 uc008vzf.2 uc008vzf.3 uc008vzf.4 uc008vzf.5 
ENSMUST00000103198.11 Nop56 ENSMUST00000103198.11 NOP56 ribonucleoprotein, transcript variant 2 (from RefSeq NR_149733.1) ENSMUST00000103198.1 ENSMUST00000103198.10 ENSMUST00000103198.2 ENSMUST00000103198.3 ENSMUST00000103198.4 ENSMUST00000103198.5 ENSMUST00000103198.6 ENSMUST00000103198.7 ENSMUST00000103198.8 ENSMUST00000103198.9 NOP56_MOUSE NR_149733 Nol5a Q3UD45 Q8BVL1 Q8VDT2 Q99LT8 Q9CT15 Q9D6Z1 uc008mil.1 uc008mil.2 uc008mil.3 Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with TCOF1 in an RNA-independent manner. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts with NOP1 and NOP58. Interacts with NUFIP1, RUVBL1 and RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP56 with NUFIP1. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus Cytoplasm Nucleus, nucleoplasm Widely expressed, with highest levels in the central nervous system (CNS), including cerebral cortex and cerebellum, and spleen. In the CNS, expressed in Purkinje cells of the cerebellum, as well as in motor neurons of the hypoglossal nucleus and in the spinal cord anterior horn (at protein level). Belongs to the NOP5/NOP56 family. fibrillar center nucleus nucleoplasm nucleolus small nucleolar ribonucleoprotein complex cytoplasm snoRNA binding box C/D snoRNP complex small-subunit processome ribosome biogenesis pre-snoRNP complex histone methyltransferase binding uc008mil.1 uc008mil.2 uc008mil.3 
ENSMUST00000103199.9 Snrpb ENSMUST00000103199.9 small nuclear ribonucleoprotein B, transcript variant 14 (from RefSeq NR_182021.1) ENSMUST00000103199.1 ENSMUST00000103199.2 ENSMUST00000103199.3 ENSMUST00000103199.4 ENSMUST00000103199.5 ENSMUST00000103199.6 ENSMUST00000103199.7 ENSMUST00000103199.8 NR_182021 P27048 Q3UJT1 RSMB_MOUSE uc008mij.1 uc008mij.2 uc008mij.3 Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:28263986). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). As part of the U7 snRNP it is involved in histone pre- mRNA 3'-end processing (PubMed:19470752). Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity). Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (PubMed:19470752). Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (By similarity). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (PubMed:19470752). Interacts with TDRD3 and SNUPN (By similarity). Interacts with PRMT5; interaction leads to its symmetric arginine dimethylation (PubMed:28263986). Interacts with TDRD6; interaction promotes association with PRMT5 (PubMed:28263986). Interacts with SMN1; the interaction is direct (By similarity). Cytoplasm, cytosol Nucleus Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. Methylated by PRMT5 (PubMed:28263986). Arg-108 and Arg-112 are dimethylated, probably to asymmetric dimethylarginine (By similarity). Belongs to the snRNP SmB/SmN family. spliceosomal snRNP assembly mRNA splicing, via spliceosome RNA binding nucleus nucleoplasm spliceosomal complex U5 snRNP U7 snRNP U1 snRNP U2 snRNP U4 snRNP U12-type spliceosomal complex telomerase holoenzyme complex cytoplasm cytosol mRNA processing protein methylation brain development RNA splicing methylosome SMN-Sm protein complex U4/U6 x U5 tri-snRNP complex telomerase RNA binding U2-type prespliceosome U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome histone pre-mRNA 3'end processing complex histone pre-mRNA DCP binding U1 snRNP binding U2 snRNP binding uc008mij.1 uc008mij.2 uc008mij.3 
ENSMUST00000103201.8 Acaca ENSMUST00000103201.8 acetyl-Coenzyme A carboxylase alpha (from RefSeq NM_133360.3) A2A6H4 ACACA_MOUSE Acac Acaca ENSMUST00000103201.1 ENSMUST00000103201.2 ENSMUST00000103201.3 ENSMUST00000103201.4 ENSMUST00000103201.5 ENSMUST00000103201.6 ENSMUST00000103201.7 Gm738 NM_133360 Q5SWU6 Q5SWU7 Q5SWU8 Q5SWU9 Q6JIZ1 Q6PHL9 Q705X8 Q705X9 Q91VC8 Q925C4 Q925C5 uc007kql.1 uc007kql.2 uc007kql.3 Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656). Reaction=acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl- CoA + phosphate; Xref=Rhea:RHEA:11308, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:456216; EC=6.4.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11309; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= Note=Binds 2 magnesium or manganese ions per subunit. Name=biotin; Xref=ChEBI:CHEBI:57586; Evidence= Inhibited by phosphorylation (By similarity). Citrate promotes oligomerization of the protein into filaments that correspond to the most active form of the carboxylase (PubMed:20952656). Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Monomer, homodimer, and homotetramer (PubMed:20952656). Can form filamentous polymers (PubMed:20952656). Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis (PubMed:12360400). Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity (PubMed:20952656, PubMed:20457939). Q5SWU9; Q9CQ20: Mid1ip1; NbExp=2; IntAct=EBI-773043, EBI-473024; Cytoplasm, cytosol Event=Alternative promoter usage; Named isoforms=2; Name=1; IsoId=Q5SWU9-1; Sequence=Displayed; Name=2; IsoId=Q5SWU9-2; Sequence=VSP_026101; Up-regulated by endocannabinoid anandamide/AEA. Consists of an N-terminal biotin carboxylation/carboxylase (BC) domain that catalyzes the ATP-dependent transient carboxylation of the biotin covalently attached to the central biotinyl-binding/biotin carboxyl carrier (BCC) domain. The C-terminal carboxyl transferase (CT) domain catalyzes the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA to produce malonyl-CoA. Phosphorylation on Ser-1262 is required for interaction with BRCA1. Phosphorylation at Ser-79 by AMPK inactivates enzyme activity. The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity. nucleotide binding fibrillar center tissue homeostasis catalytic activity acetyl-CoA carboxylase activity biotin carboxylase activity protein binding ATP binding cytoplasm mitochondrion cytosol acetyl-CoA metabolic process lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process metabolic process biotin binding response to organic cyclic compound actin cytoskeleton ligase activity protein metabolic process kinase binding identical protein binding metal ion binding protein homotetramerization lipid homeostasis cellular response to prostaglandin E stimulus malonyl-CoA biosynthetic process uc007kql.1 uc007kql.2 uc007kql.3 
ENSMUST00000103204.11 Per3 ENSMUST00000103204.11 period circadian clock 3, transcript variant 2 (from RefSeq NM_011067.3) A2A894 ENSMUST00000103204.1 ENSMUST00000103204.10 ENSMUST00000103204.2 ENSMUST00000103204.3 ENSMUST00000103204.4 ENSMUST00000103204.5 ENSMUST00000103204.6 ENSMUST00000103204.7 ENSMUST00000103204.8 ENSMUST00000103204.9 NM_011067 O70361 PER3_MOUSE uc008vye.1 uc008vye.2 uc008vye.3 uc008vye.4 This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. Homodimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1, PER2, CRY1, CRY2, and TIMELESS; interaction with CRY1 and CRY2 is weak and not rhythmic. Interacts with FBXW11 and BTRC. Cytoplasm cleus te=Mainly cytoplasmic. Translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS. Widely expressed. Expressed in heart, brain, lung, liver, skeletal muscle, testis, and at low level in the spleen and kidney. In brain, mainly found in the SCN, hippocampus, piriform cortex, and cerebellum. Lower level of expression in the neocortex. Expression exhibits synchronous oscillations in liver, skeletal muscle and testis. Exhibits circadian oscillation expression in SCN, liver, skeletal muscle, testis and eyes. In the SCN, highest levels during subjective day at CT6 and CT9, lowest levels at night, CT15, CT18 and CT 21. In the liver, skeletal muscle, testis and eyes highest levels at CT15, CT15-CT18, CT9 and CT15, and CT9-CT15, respectively. During subjective night, unresponsive to light exposure. Phosphorylation by CSNK1E is weak and appears to require association with PER1 and translocation to the nucleus. Ubiquitinated. Animals show altered sleep and behavioral activity whitout changes in total activity or vigilance states. They have increased wheel-running activity and reduced REM (rapid eye movement) sleep and NREM (non-REM) sleep in the middle of the dark phase. At the beginning of the baseline light period, they have less wakefulness and more REM and NREM sleep. Mice spend less time in wakefulness and more time in NREM sleep on the light period immediately after sleep deprivation and REM sleep accumulates more slowly during the recovery dark phase. They also display a depression-like phenotype. Double knocknouts for PER2 and PER3 show the same phenotype as PER2 knockouts with severely disrupted circadian behavior. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding transcription corepressor binding protein binding nucleus cytoplasm circadian rhythm transcription factor binding response to light stimulus kinase binding ubiquitin protein ligase binding circadian regulation of gene expression entrainment of circadian clock by photoperiod regulation of circadian sleep/wake cycle, sleep rhythmic process protein stabilization uc008vye.1 uc008vye.2 uc008vye.3 uc008vye.4 
ENSMUST00000103205.11 Polr1b ENSMUST00000103205.11 polymerase (RNA) I polypeptide B (from RefSeq NM_009086.2) ENSMUST00000103205.1 ENSMUST00000103205.10 ENSMUST00000103205.2 ENSMUST00000103205.3 ENSMUST00000103205.4 ENSMUST00000103205.5 ENSMUST00000103205.6 ENSMUST00000103205.7 ENSMUST00000103205.8 ENSMUST00000103205.9 NM_009086 P70700 Q3UMX7 RPA2_MOUSE Rpa2 Rpo1-2 uc008mhf.1 uc008mhf.2 uc008mhf.3 uc008mhf.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA- COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21249; Evidence=; Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits. Nucleus, nucleolus Chromosome Belongs to the RNA polymerase beta chain family. DNA binding DNA-directed 5'-3' RNA polymerase activity protein binding nucleus nucleoplasm nucleolus DNA-directed RNA polymerase I complex cytosol transcription, DNA-templated transcription from RNA polymerase I promoter embryo implantation rRNA transcription transferase activity nucleotidyltransferase activity nucleologenesis ribonucleoside binding metal ion binding RNA polymerase I activity uc008mhf.1 uc008mhf.2 uc008mhf.3 uc008mhf.4 
ENSMUST00000103212.10 Ube4b ENSMUST00000103212.10 ubiquitination factor E4B, transcript variant 1 (from RefSeq NM_022022.4) ENSMUST00000103212.1 ENSMUST00000103212.2 ENSMUST00000103212.3 ENSMUST00000103212.4 ENSMUST00000103212.5 ENSMUST00000103212.6 ENSMUST00000103212.7 ENSMUST00000103212.8 ENSMUST00000103212.9 NM_022022 Q6DID4 Q9EQE0 Q9ES00 UBE4B_MOUSE Ube4b Ufd2 Ufd2a uc012dpr.1 uc012dpr.2 uc012dpr.3 Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (PubMed:11435423). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with VCP (PubMed:12504083). Interacts with STUB1/CHIP and UNC45B (By similarity). Cytoplasm cleus Expressed predominantly in neuronal tissues. Also detected in liver, heart, brain, kidney and testis. The U-box domain is required for the ubiquitin protein ligase activity. Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7 (By similarity). In strain C57BL/Ola, a 85 kb region on chromosome 4 containing Nmnat1 and Ube4b is triplicated. Ube4b becomes linked to Nmnat1 and encodes a fusion protein located in the nucleus which is responsible for the delayed Wallerian degeneration of injured axons in C57BL/Ola. Belongs to the ubiquitin conjugation factor E4 family. ubiquitin ligase complex protein polyubiquitination ventricular trabecula myocardium morphogenesis ubiquitin-protein transferase activity protein binding ATP binding nucleus cytoplasm protein folding ubiquitin-dependent protein catabolic process protein monoubiquitination granzyme-mediated apoptotic signaling pathway response to UV protein ubiquitination transferase activity enzyme binding ER-associated ubiquitin-dependent protein catabolic process neuron projection development ubiquitin-ubiquitin ligase activity response to endoplasmic reticulum stress proteasome-mediated ubiquitin-dependent protein catabolic process cellular protein catabolic process unfolded protein binding ATPase binding protein autoubiquitination ubiquitin protein ligase activity uc012dpr.1 uc012dpr.2 uc012dpr.3 
ENSMUST00000103213.10 Nle1 ENSMUST00000103213.10 notchless homolog 1 (from RefSeq NM_145431.2) B1ARD5 ENSMUST00000103213.1 ENSMUST00000103213.2 ENSMUST00000103213.3 ENSMUST00000103213.4 ENSMUST00000103213.5 ENSMUST00000103213.6 ENSMUST00000103213.7 ENSMUST00000103213.8 ENSMUST00000103213.9 NLE1_MOUSE NM_145431 Q8VEJ4 uc007knt.1 uc007knt.2 uc007knt.3 uc007knt.4 Plays a role in regulating Notch activity (Probable). Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival. Nucleus, nucleolus Highest expression in heart, brain, lung, liver, skeletal muscle and testis with lower levels in spleen and kidney. Expression detected in the embryo at 7.0 dpc, 11.0 dpc and 15.0 dpc and also in the adult. Embryonic lethality prior to 6.5 dpc with death of inner mass cells. Embryos implant but die shortly after. ribosomal large subunit assembly somitogenesis kidney development inner cell mass cell differentiation molecular_function nucleus nucleolus Notch signaling pathway ribosomal large subunit biogenesis negative regulation of mitotic cell cycle skeletal system morphogenesis hematopoietic stem cell homeostasis positive regulation of canonical Wnt signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway uc007knt.1 uc007knt.2 uc007knt.3 uc007knt.4 
ENSMUST00000103217.11 Pex14 ENSMUST00000103217.11 peroxisomal biogenesis factor 14 (from RefSeq NM_019781.3) ENSMUST00000103217.1 ENSMUST00000103217.10 ENSMUST00000103217.2 ENSMUST00000103217.3 ENSMUST00000103217.4 ENSMUST00000103217.5 ENSMUST00000103217.6 ENSMUST00000103217.7 ENSMUST00000103217.8 ENSMUST00000103217.9 NM_019781 PEX14_MOUSE Pex14 Q9R0A0 uc008vvp.1 uc008vvp.2 uc008vvp.3 Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin (By similarity). Interacts with PEX13; forming the PEX13-PEX14 docking complex. Interacts with PEX5 (via WxxxF/Y motifs). Interacts with PEX19. Interacts with tubulin. Peroxisome membrane ; Single-pass membrane protein Belongs to the peroxin-14 family. fibrillar center transcription corepressor activity receptor binding peroxisome peroxisomal membrane peroxisome organization microtubule binding protein transport membrane integral component of membrane protein import into peroxisome matrix protein import into peroxisome matrix, docking protein import into peroxisome matrix, translocation negative regulation of protein binding macromolecular complex microtubule anchoring peroxisome transport along microtubule negative regulation of sequence-specific DNA binding transcription factor activity protein import into peroxisome matrix, substrate release negative regulation of transcription, DNA-templated protein N-terminus binding beta-tubulin binding protein homooligomerization macromolecular complex assembly negative regulation of protein homotetramerization peroxisomal importomer complex uc008vvp.1 uc008vvp.2 uc008vvp.3 
ENSMUST00000103220.4 Snrnp200 ENSMUST00000103220.4 small nuclear ribonucleoprotein 200 (U5) (from RefSeq NM_177214.5) ENSMUST00000103220.1 ENSMUST00000103220.2 ENSMUST00000103220.3 Kiaa0788 NM_177214 Q69ZZ3 Q6P4T2 U520_MOUSE uc008mez.1 uc008mez.2 uc008mez.3 On February 19, 2002, this locus was switched from human to mouse. The source accession, Z70200.1, is almost identical to the mouse BAC clone AC074224, and it matches the mouse cDNA accession BC011390 as well. The human gene is LocusID 23020. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC063261.1, SRR1660817.190241.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. As a component of the minor spliceosome, involved in the splicing of U12- type introns in pre-mRNAs (By similarity). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Component of a core complex containing at least PRPF8, SNRNP200, EFTUD2 and SNRNP40. Component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes, building blocks of the spliceosome. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the minor spliceosome, which splices U12-type introns (By similarity). Interacts with C9orf78; the interaction is direct and mutually exclusive with its interaction with WBP4. Interacts with WBP4; the interaction is mutually exclusive with its interaction with C9orf78. Interacts with PRPF8. Interacts with TSSC4; the interaction is direct, excludes recruitment of C9ORF78 and WBP4 to SNRNP200 and negatively regulates its RNA helicase activity (By similarity). Nucleus Contains two helicase domains. The N-terminal helicase domain has catalytic activity by itself, contrary to C-terminal helicase domain that may have a regulatory role and enhance the activity of the first helicase domain. Belongs to the helicase family. SKI2 subfamily. nucleotide binding spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) mRNA splicing, via spliceosome nucleic acid binding RNA helicase activity helicase activity ATP binding nucleus nucleoplasm spliceosomal complex U5 snRNP mRNA processing RNA splicing hydrolase activity identical protein binding U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome U2-type catalytic step 1 spliceosome catalytic step 2 spliceosome post-mRNA release spliceosomal complex uc008mez.1 uc008mez.2 uc008mez.3 
ENSMUST00000103221.10 Mtor ENSMUST00000103221.10 mechanistic target of rapamycin kinase (from RefSeq NM_020009.2) ENSMUST00000103221.1 ENSMUST00000103221.2 ENSMUST00000103221.3 ENSMUST00000103221.4 ENSMUST00000103221.5 ENSMUST00000103221.6 ENSMUST00000103221.7 ENSMUST00000103221.8 ENSMUST00000103221.9 Frap Frap1 MTOR_MOUSE Mtor NM_020009 Q2KHT0 Q811J5 Q9CST1 Q9JLN9 uc008vur.1 uc008vur.2 uc008vur.3 uc008vur.4 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:15467718, PubMed:15545625, PubMed:15485918, PubMed:16221682, PubMed:16915281, PubMed:16962653, PubMed:18046414, PubMed:19440205, PubMed:21659604). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15467718, PubMed:15545625, PubMed:16221682, PubMed:16915281, PubMed:16962653, PubMed:18046414, PubMed:19440205, PubMed:21659604). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15467718, PubMed:16962653, PubMed:21659604). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:15485918). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:15485918). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:15485918). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (By similarity). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (By similarity). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (By similarity). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:11792863). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (PubMed:18046414). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:21258367). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:21258367). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (By similarity). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (By similarity). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (By similarity). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR- dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (By similarity). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (By similarity). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:27913603). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:27913603). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (PubMed:19346248). As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. mTORC2 plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (By similarity). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (PubMed:19440205). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (PubMed:29750810). Phosphorylates SQSTM1, promoting interaction between SQSTM1 and KEAP1 and subsequent inactivation of the BCR(KEAP1) complex (PubMed:24011591). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; The mTORC1 complex is activated in response to nutrients, growth factors or amino acids: activation requires relocalization of the mTORC1 complex to lysosomes that is mediated by the Ragulator complex, SLC38A9, and the Rag GTPases RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and RagD/RRAGD (By similarity). Activation of mTORC1 by growth factors such as insulin involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase a potent activator of the protein kinase activity of mTORC1 (By similarity). Insulin-stimulated and amino acid-dependent phosphorylation at Ser-1261 promotes autophosphorylation and the activation of mTORC1 (PubMed:19487463). On the other hand, low cellular energy levels can inhibit mTORC1 through activation of PRKAA1 while hypoxia inhibits mTORC1 through a REDD1-dependent mechanism which may also require PRKAA1 (PubMed:15545625). The kinase activity of MTOR within the mTORC1 complex is positively regulated by MLST8 (By similarity). The kinase activity of MTOR is inhibited by DEPTOR and AKT1S1 (By similarity). The non-canonical mTORC1 complex is independent of the RHEB GTPase and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3 but not other mTORC1 substrates: it is activated by FLCN, which activates Rag GTPases RagC/RRAGC and RagD/RRAGD (By similarity). MTOR is the target of the immunosuppressive and anti- cancer drug rapamycin which acts in complex with FKBP1A/FKBP12, and specifically inhibits its kinase activity (PubMed:7809080). mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive (By similarity). mTORC2 may also be regulated by RHEB but in an indirect manner through the PI3K signaling pathway (By similarity). Part of the mechanistic target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8 and RPTOR (PubMed:20801936). The mTORC1 complex is a 1 Md obligate dimer of two stoichiometric heterotetramers with overall dimensions of 290 A x 210 A x 135 A (By similarity). It has a rhomboid shape and a central cavity, the dimeric interfaces are formed by interlocking interactions between the two MTOR and the two RPTOR subunits (By similarity). The MLST8 subunit forms distal foot- like protuberances, and contacts only one MTOR within the complex, while the small AKT1S1/PRAS40 localizes to the midsection of the central core, in close proximity to RPTOR (By similarity). mTORC1 associates with AKT1S1/PRAS40, which inhibits its activity by blocking MTOR substrate-recruitment site (By similarity). Part of the mechanistic target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (PubMed:15467718, PubMed:16962653). Interacts with PLPP7 and PML (PubMed:16915281, PubMed:19704009). Interacts with PRR5 and RICTOR; the interaction is direct within the mTORC2 complex and interaction with RICTOR is enhanced by deubiquitination of RICTOR by USP9X (PubMed:20801936). mTORC1 and mTORC2 associate with DEPTOR, which regulates its activity (By similarity). Interacts with WAC; WAC positively regulates MTOR activity by promoting the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex which leads to the dimerization of the mTORC1 complex and its subsequent activation (By similarity). Interacts with UBQLN1 (By similarity). Interacts with TTI1 and TELO2 (By similarity). Interacts with CLIP1; phosphorylates and regulates CLIP1 (By similarity). Interacts with NBN (By similarity). Interacts with HTR6 (PubMed:23027611). Interacts with BRAT1 (By similarity). Interacts with MEAK7 (via C-terminal domain); the interaction increases upon nutrient stimulation (By similarity). Interacts with TM4SF5; the interaction is positively regulated by arginine and is negatively regulated by leucine (By similarity). Interacts with GPR137B (By similarity). Interacts with NCKAP1L (By similarity). Interacts with TPCN1 and TPCN2; the interaction is required for TPCN1 and TPCN2 sensitivity to ATP (By similarity). Interacts with ATP6V1A and with CRYAB, forming a ternary complex (PubMed:31786107). Interacts with SLC38A7; this interaction mediates the recruitment of mTORC1 to the lysosome and its subsequent activation (By similarity). Q9JLN9; Q9DCH4: Eif3f; NbExp=5; IntAct=EBI-1571628, EBI-1634316; Q9JLN9; Q6QI06: Rictor; NbExp=12; IntAct=EBI-1571628, EBI-4286572; Q9JLN9; Q8K4Q0: Rptor; NbExp=9; IntAct=EBI-1571628, EBI-4567273; Q9JLN9; O70405: Ulk1; NbExp=3; IntAct=EBI-1571628, EBI-8390771; Q9JLN9; Q00899: Yy1; NbExp=4; IntAct=EBI-1571628, EBI-6921536; Q9JLN9; Q13541: EIF4EBP1; Xeno; NbExp=2; IntAct=EBI-1571628, EBI-74090; Q9JLN9; Q8N122: RPTOR; Xeno; NbExp=5; IntAct=EBI-1571628, EBI-1567928; Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm cleus Nucleus, PML body Microsome membrane Cytoplasmic vesicle, phagosome Note=Shuttles between cytoplasm and nucleus (PubMed:16915281). Accumulates in the nucleus in response to hypoxia (PubMed:16915281). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (By similarity). Lysosome targeting also depends on interaction with MEAK7 (By similarity). Translocates to the lysosome membrane in the presence of TM4SF5 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JLN9-1; Sequence=Displayed; Name=2; IsoId=Q9JLN9-2; Sequence=VSP_011909, VSP_011910; The kinase domain (PI3K/PI4K) is intrinsically active but has a highly restricted catalytic center. The FAT domain forms three discontinuous subdomains of alpha- helical TPR repeats plus a single subdomain of HEAT repeats. The four domains pack sequentially to form a C-shaped a-solenoid that clamps onto the kinase domain (By similarity). Autophosphorylates when part of mTORC1 or mTORC2 (By similarity). Phosphorylation at Ser-1261, Ser-2159 and Thr-2164 promotes autophosphorylation (PubMed:19487463). Phosphorylation in the kinase domain modulates the interactions of MTOR with RPTOR and AKT1S1/PRAS40 and leads to increased intrinsic mTORC1 kinase activity (By similarity). Phosphorylation at Ser-2159 by TBK1 in response to growth factors and pathogen recognition receptors promotes mTORC1 activity (PubMed:29150432). Phosphorylation at Thr-2173 in the ATP-binding region by AKT1 strongly reduces kinase activity (By similarity). Early embryonic lethality (PubMed:15485918). Embryonic development stops at 5.5 dpc and embryos are severely runted and display an aberrant developmental phenotype (PubMed:15485918). Embryos are able to implant due to a maternal mRNA contribution, which persists during preimplantation development (PubMed:15485918). Embryos display a lesion in inner cell mass proliferation, due to the inability to establish embryonic stem cells (PubMed:15485918). Belongs to the PI3/PI4-kinase family. Golgi membrane nucleotide binding RNA polymerase III type 1 promoter DNA binding RNA polymerase III type 2 promoter DNA binding RNA polymerase III type 3 promoter DNA binding TFIIIC-class transcription factor binding regulation of cell growth regulation of protein phosphorylation negative regulation of protein phosphorylation positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation T-helper 1 cell lineage commitment heart morphogenesis heart valve morphogenesis protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm mitochondrion mitochondrial outer membrane lysosome lysosomal membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol regulation of glycogen biosynthetic process regulation of carbohydrate metabolic process energy reserve metabolic process 'de novo' pyrimidine nucleobase biosynthetic process protein phosphorylation germ cell development brain development cell aging response to nutrient long-term memory regulation of cell size visual learning cellular response to starvation post-embryonic development negative regulation of autophagy positive regulation of lamellipodium assembly positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of myotube differentiation positive regulation of cell death positive regulation of neuron projection development endomembrane system positive regulation of neuron maturation negative regulation of muscle atrophy response to activity membrane negative regulation of macroautophagy kinase activity phosphorylation PML body transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation protein kinase binding protein domain specific binding spinal cord development cell projection organization dendrite positive regulation of actin filament polymerization negative regulation of protein ubiquitination ruffle organization regulation of myelination response to nutrient levels cellular response to nutrient levels TOR signaling TORC1 complex TORC2 complex regulation of fatty acid beta-oxidation regulation of response to food response to insulin regulation of actin cytoskeleton organization macromolecular complex cellular response to amino acid starvation social behavior multicellular organism growth TORC1 signaling wound healing response to cocaine regulation of circadian rhythm identical protein binding ribosome binding neuronal cell body regulation of GTPase activity response to amino acid response to morphine regulation of carbohydrate utilization macromolecular complex binding translation regulator activity positive regulation of nitric oxide biosynthetic process regulation of osteoclast differentiation positive regulation of translation negative regulation of cell size regulation of protein kinase activity positive regulation of transcription from RNA polymerase III promoter protein autophosphorylation positive regulation of lipid biosynthetic process mRNA stabilization rhythmic process positive regulation of smooth muscle cell proliferation positive regulation of oligodendrocyte differentiation cardiac muscle tissue development positive regulation of peptidyl-tyrosine phosphorylation positive regulation of neurogenesis voluntary musculoskeletal movement phosphoprotein binding positive regulation of stress fiber assembly positive regulation of keratinocyte migration regulation of protein kinase B signaling positive regulation of protein kinase B signaling cardiac cell development cardiac muscle cell development cardiac muscle contraction maternal process involved in female pregnancy positive regulation of glial cell proliferation positive regulation of dendritic spine development positive regulation of cell growth involved in cardiac muscle cell development negative regulation of calcineurin-NFAT signaling cascade cellular response to amino acid stimulus cellular response to leucine cellular response to hypoxia regulation of brown fat cell differentiation regulation of membrane permeability glutamatergic synapse postsynaptic cytosol regulation of translation at synapse, modulating synaptic transmission positive regulation of neuron death positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter positive regulation of wound healing, spreading of epidermal cells positive regulation of eating behavior positive regulation of cholangiocyte proliferation positive regulation of sensory perception of pain regulation of locomotor rhythm negative regulation of cholangiocyte apoptotic process positive regulation of granulosa cell proliferation positive regulation of skeletal muscle hypertrophy negative regulation of iodide transmembrane transport cellular response to leucine starvation uc008vur.1 uc008vur.2 uc008vur.3 uc008vur.4 
ENSMUST00000103223.8 Spaca3 ENSMUST00000103223.8 sperm acrosome associated 3, transcript variant 1 (from RefSeq NM_001359183.1) ENSMUST00000103223.1 ENSMUST00000103223.2 ENSMUST00000103223.3 ENSMUST00000103223.4 ENSMUST00000103223.5 ENSMUST00000103223.6 ENSMUST00000103223.7 Lyc3 Lyzl3 NM_001359183 Q5SUU3 Q6PKP1 Q6PX67 Q9D9X8 SACA3_MOUSE Sllp1 uc011yav.1 uc011yav.2 uc011yav.3 Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N- acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro (By similarity). Interacts with ASTL. Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Single-pass type II membrane protein Note=Anterior acrosome in non- capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction. [Isoform 2]: Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D9X8-1; Sequence=Displayed; Name=2; IsoId=Q9D9X8-2; Sequence=VSP_021330; The processed form is expressed in sperm (at protein level). Expressed strongly in testis and epididymis and weakly in pancreas. Belongs to the glycosyl hydrolase 22 family. Although it belongs to the glycosyl hydrolase 22 family, Thr- 128 and Asn-145 are present instead of the conserved Glu and Asp which are active site residues. It is therefore expected that this protein lacks hydrolase activity. acrosomal vesicle acrosomal membrane lysozyme activity protein binding extracellular region fusion of sperm to egg plasma membrane fertilization membrane integral component of membrane secretory granule cytoplasmic vesicle sperm-egg recognition acrosomal matrix defense response to Gram-negative bacterium defense response to Gram-positive bacterium uc011yav.1 uc011yav.2 uc011yav.3 
ENSMUST00000103224.10 Trpm7 ENSMUST00000103224.10 transient receptor potential cation channel, subfamily M, member 7, transcript variant 1 (from RefSeq NM_021450.2) A2AI58 Chak ENSMUST00000103224.1 ENSMUST00000103224.2 ENSMUST00000103224.3 ENSMUST00000103224.4 ENSMUST00000103224.5 ENSMUST00000103224.6 ENSMUST00000103224.7 ENSMUST00000103224.8 ENSMUST00000103224.9 Ltrpc7 NM_021450 Q8C7S7 Q8CE54 Q921Y5 Q923J1 Q925B2 Q9CUT2 Q9JLQ1 TRPM7_MOUSE uc008mef.1 uc008mef.2 uc008mef.3 uc008mef.4 Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Forms heterodimers with TRPM6. Interacts with PLCB1 (By similarity). Homodimer. Q923J1; P60710: Actb; NbExp=2; IntAct=EBI-8010314, EBI-353957; Q923J1; Q3U1J4: Ddb1; NbExp=2; IntAct=EBI-8010314, EBI-2552275; Q923J1; Q8VDD5: Myh9; NbExp=4; IntAct=EBI-8010314, EBI-400906; Q923J1; O00571: DDX3X; Xeno; NbExp=2; IntAct=EBI-8010314, EBI-353779; Q923J1; Q8N488: RYBP; Xeno; NbExp=3; IntAct=EBI-8010314, EBI-752324; Membrane ; Multi-pass membrane protein Found to be expressed in brain and skeletal muscle, with stronger signals in kidney, heart, liver and spleen. Autophosphorylated. In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily. nucleotide binding ruffle actin binding protein kinase activity protein serine/threonine kinase activity ion channel activity cation channel activity calcium channel activity protein binding ATP binding cytoplasm plasma membrane protein phosphorylation ion transport cation transport calcium ion transport memory cellular magnesium ion homeostasis programmed cell death membrane integral component of membrane kinase activity phosphorylation calcium-dependent cell-matrix adhesion transferase activity myosin binding synaptic vesicle membrane actomyosin structure organization neuron projection neuronal cell body positive regulation of apoptotic process varicosity protein autophosphorylation metal ion binding protein tetramerization transmembrane transport necroptotic process calcium ion transmembrane transport uc008mef.1 uc008mef.2 uc008mef.3 uc008mef.4 
ENSMUST00000103225.11 5730455P16Rik ENSMUST00000103225.11 RIKEN cDNA 5730455P16 gene (from RefSeq NM_027472.3) ENSMUST00000103225.1 ENSMUST00000103225.10 ENSMUST00000103225.2 ENSMUST00000103225.3 ENSMUST00000103225.4 ENSMUST00000103225.5 ENSMUST00000103225.6 ENSMUST00000103225.7 ENSMUST00000103225.8 ENSMUST00000103225.9 NJMU_MOUSE NM_027472 Q7TMQ9 Q9CYI0 uc007klv.1 uc007klv.2 uc007klv.3 uc007klv.4 May have a role in spermatogenesis. Interacts with TBC1D23; this interaction may be indirect. molecular_function trans-Golgi network intracellular protein transport cytoplasmic vesicle vesicle tethering to Golgi uc007klv.1 uc007klv.2 uc007klv.3 uc007klv.4 
ENSMUST00000103227.8 Gabpb1 ENSMUST00000103227.8 GA repeat binding protein, beta 1, transcript variant 45 (from RefSeq NM_001406226.1) ENSMUST00000103227.1 ENSMUST00000103227.2 ENSMUST00000103227.3 ENSMUST00000103227.4 ENSMUST00000103227.5 ENSMUST00000103227.6 ENSMUST00000103227.7 Gabpb1 NM_001406226 Q3US22 Q3US22_MOUSE uc008mdu.1 uc008mdu.2 uc008mdu.3 uc008mdu.4 uc008mdu.1 uc008mdu.2 uc008mdu.3 uc008mdu.4 
ENSMUST00000103230.5 Nppa ENSMUST00000103230.5 natriuretic peptide type A (from RefSeq NM_008725.3) ANF_MOUSE ENSMUST00000103230.1 ENSMUST00000103230.2 ENSMUST00000103230.3 ENSMUST00000103230.4 NM_008725 P05125 Pnd Q5FW59 uc008vtq.1 uc008vtq.2 uc008vtq.3 uc008vtq.4 This gene encodes members of the natriuretic family of peptides that play an important role in the control of extracellular fluid volume and electrolyte homeostasis. The encoded protein precursor undergoes proteolytic processing to generate multiple functional peptides. Mice lacking the encoded peptides exhibit salt-sensitive hypertension. The transgenic overexpression of the encoded peptides in mice decreases arterial blood pressure without inducing diuresis and natriuresis. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 4. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC089615.1, CA787031.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## [Atrial natriuretic peptide]: Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (PubMed:8760210, PubMed:22437503, PubMed:12890708). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (PubMed:12890708). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (PubMed:8760210, PubMed:22437503). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (By similarity). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (PubMed:22437503). In adipose tissue, acts in various cGMP- and PKG- dependent pathways to regulate lipid metabolism and energy homeostasis (By similarity). This includes up-regulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (By similarity). Binds the clearance receptor NPR3 which removes the hormone from circulation (By similarity). [Long-acting natriuretic peptide]: May have a role in cardio- renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (By similarity). [Vessel dilator]: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides. Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption. [Kaliuretic peptide]: May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+- ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption. [Urodilatin]: Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney. [Auriculin-D]: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips. [Auriculin-B]: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips. [Auriculin-A]: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips. [Atriopeptin-2]: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips. [Atriopeptin-1]: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips. [Atrial natriuretic peptide]: Homodimer; disulfide-linked antiparallel dimer. [Long-acting natriuretic peptide]: Secreted Note=Detected in blood. [Vessel dilator]: Secreted Note=Detected in blood. [Kaliuretic peptide]: Secreted Note=Detected in blood. [Urodilatin]: Secreted Note=Detected in urine. Not detected in blood. Increased electrolytes, osmolality and intracellular cAMP levels increase peptide secretion/excretion. [Atrial natriuretic peptide]: Secreted Perikaryon Cell projection Note=Detected in blood. Detected in urine in one study. However, in another study, was not detected in urine. Detected in cytoplasmic bodies and neuronal processes of pyramidal neurons (layers II-VI) (By similarity). Increased secretion in response to the vasopressin AVP (By similarity). Likely to be secreted in response to an increase in atrial pressure or atrial stretch. In kidney cells, secretion increases in response to activated guanylyl cyclases and increased intracellular cAMP levels. Plasma levels increase 15 minutes after a high-salt meal, and decrease back to normal plasma levels 1 hr later (By similarity). [Atriopeptin-3]: Secreted Note=Detected in blood. Slight increase in secretion in response to the vasopressin AVP. The precursor molecule is proteolytically cleaved by CORIN at Arg- 122 to produce atrial natriuretic peptide (PubMed:11884416, PubMed:15637153). Undergoes further proteolytic cleavage by unknown proteases to give rise to long-acting natriuretic peptide, vessel dilator and kaliuretic peptide (By similarity). Additional processing gives rise to the auriculin and atriopeptin peptides (By similarity). In the kidneys, alternative processing by an unknown protease results in the peptide urodilatin (By similarity). [Atrial natriuretic peptide]: Cleavage by MME initiates degradation of the factor and thereby regulates its activity. Degradation by IDE results in reduced activation of NPR1 (in vitro). During IDE degradation, the resulting products can temporarily stimulate NPR2 to produce cGMP, before the fragments are completely degraded and inactivated by IDE (in vitro). [Urodilatin]: Degraded by IDE. [Urodilatin]: Phosphorylation on Ser-128 decreases vasorelaxant activity. Mice display increased arterial blood pressure which is dietary salt intake independent (PubMed:8760210). During pregnancy, increased blood pressure is observed, leading to late gestational proteinuria and smaller litters (PubMed:22437503). Impaired trophoblast invasion and smaller spiral arteries are also observed in 12.5 dpc embryos (PubMed:22437503). In 18.5 dpc embryos, mice display fewer trophoblasts and smaller arteries in the decidua and myometrium than those in wild-type mice (PubMed:22437503). Belongs to the natriuretic peptide family. [Long-acting natriuretic peptide]: Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, an in vivo study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity). [Vessel dilator]: Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, a heterologous and in vivo expression study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity). response to hypoxia negative regulation of systemic arterial blood pressure receptor binding hormone activity neuropeptide hormone activity extracellular region extracellular space nucleus cytoplasm cGMP biosynthetic process protein folding receptor guanylyl cyclase signaling pathway neuropeptide signaling pathway female pregnancy regulation of blood pressure positive regulation of heart rate positive regulation of cGMP-mediated signaling cardiac muscle hypertrophy in response to stress cGMP-mediated signaling negative regulation of cell growth response to insulin macromolecular complex negative regulation of epidermal growth factor receptor signaling pathway mast cell granule perinuclear region of cytoplasm hormone receptor binding regulation of atrial cardiac muscle cell membrane repolarization positive regulation of cardiac muscle contraction cell growth involved in cardiac muscle cell development cellular response to mechanical stimulus neuropeptide receptor binding negative regulation of canonical Wnt signaling pathway regulation of high voltage-gated calcium channel activity positive regulation of delayed rectifier potassium channel activity regulation of calcium ion transmembrane transport via high voltage-gated calcium channel positive regulation of histamine secretion by mast cell positive regulation of potassium ion export across plasma membrane negative regulation of collecting lymphatic vessel constriction uc008vtq.1 uc008vtq.2 uc008vtq.3 uc008vtq.4 
ENSMUST00000103231.5 Nppb ENSMUST00000103231.5 natriuretic peptide type B, transcript variant 1 (from RefSeq NM_008726.6) BNP ENSMUST00000103231.1 ENSMUST00000103231.2 ENSMUST00000103231.3 ENSMUST00000103231.4 NM_008726 Nppb Q54AE9 Q54AE9_MOUSE uc008vto.1 uc008vto.2 uc008vto.3 uc008vto.4 This gene encodes a secreted protein that belongs to the family of natriuretic peptides. Its precursor protein is processed to generate the active mature peptide. The mature peptide is a cardiac hormone that plays a role in ventricular remodeling as well as blood pressure regulation. Mice lacking this gene exhibit cardiac fibrosis. In humans this gene is associated with congestive heart failure, low bone-mineral density and postmenopausal osteoporosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]. Secreted Belongs to the natriuretic peptide family. hormone activity extracellular region signal transduction uc008vto.1 uc008vto.2 uc008vto.3 uc008vto.4 
ENSMUST00000103232.2 2510039O18Rik ENSMUST00000103232.2 RIKEN cDNA 2510039O18 gene (from RefSeq NM_029841.3) B2KFU4 ENSMUST00000103232.1 K2013_MOUSE Kiaa2013 NM_029841 Q3U5A6 Q69Z34 Q91X21 Q9CY11 uc008vtm.1 uc008vtm.2 Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q91X21-1; Sequence=Displayed; Name=2; IsoId=Q91X21-2; Sequence=VSP_026489; Name=3; IsoId=Q91X21-3; Sequence=VSP_026488, VSP_026489; Sequence=BAD32610.1; Type=Erroneous initiation; Evidence=; molecular_function biological_process membrane integral component of membrane uc008vtm.1 uc008vtm.2 
ENSMUST00000103234.2 Fbn1 ENSMUST00000103234.2 [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor- beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (By similarity). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (PubMed:20855508). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction plays an important role in the assembly of microfibrils (By similarity). (from UniProt Q61554) A2AQ53 ENSMUST00000103234.1 FBN1_MOUSE Fbn-1 Fbn1 L29454 Q60826 Q61554 uc008mcq.1 uc008mcq.2 uc008mcq.3 [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor- beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (By similarity). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (PubMed:20855508). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction plays an important role in the assembly of microfibrils (By similarity). [Asprosin]: Adipokine secreted by white adipose tissue that plays an important regulatory role in the glucose metabolism of liver, muscle and pancreas (PubMed:31230984, PubMed:30997682). Hormone that targets the liver in response to fasting to increase plasma glucose levels (PubMed:31230984). Binds the olfactory receptor Olfr734 at the surface of hepatocytes and promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation (PubMed:31230984). May act as a regulator of adaptive thermogenesis by inhibiting browning and energy consumption, while increasing lipid deposition in white adipose tissue (PubMed:33705351). Also acts as an orexigenic hormone that increases appetite: crosses the blood brain barrier and exerts effects on the hypothalamus (PubMed:29106398). In the arcuate nucleus of the hypothalamus, asprosin directly activates orexigenic AgRP neurons and indirectly inhibits anorexigenic POMC neurons, resulting in appetite stimulation (PubMed:29106398, PubMed:32337066). Activates orexigenic AgRP neurons via binding to the olfactory receptor Olfr734 (PubMed:32337066). May also play a role in sperm motility in testis via interaction with Olfr734 receptor (PubMed:31798959). [Fibrillin-1]: Interacts with COL16A1. Interacts with integrin alpha-V/beta-3. Interacts with ADAMTS10; this interaction promotes microfibril assembly (By similarity). Interacts with THSD4; this interaction promotes fibril formation (PubMed:19940141). Interacts (via N-terminal domain) with FBLN2 and FBLN5. Interacts with ELN. Forms a ternary complex with ELN and FBLN2 or FBLN5 and a significant interaction with ELN seen only in the presence of FBLN2 or FBLN5. Interacts (via N-terminal domain) with LTBP2 (via C-terminal domain) in a Ca(+2)-dependent manner. Interacts (via N-terminal domain) with LTBP1 (via C-terminal domain). Interacts with integrins ITGA5:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. Interacts (via N-terminal domain) with BMP2, BMP4, BMP7, BMP10 and GDF5. Interacts (via N-terminal domain) with MFAP2 and MFAP5. Interacts with ADAMTSL5. Interacts with MFAP4. Interacts (via N-terminal domain) with TNFSF11 in a Ca(+2)-dependent manner (By similarity). Interacts (via N-terminal domain) with EFEMP2; this interaction inhibits EFEMP2 binding to LOX and ELN (By similarity). Secreted Note=Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin. [Fibrillin-1]: Secreted, extracellular space, extracellular matrix [Asprosin]: Secreted Note=Secreted by white adipose tissue and circulates in the plasma. [Fibrillin-1]: Strongly expressed during the first week of osteoblast differentiation. [Asprosin]: Secreted by white adipose tissue (at protein level). [Asprosin]: Displays circadian oscillation with an acute decrease in levels coinciding with the onset of feeding (at protein level) (PubMed:27087445). Cleavage of N- and C-terminus by furin is required for incorporation into the extracellular matrix and assembly into microfibrils. The C-terminus, which corresponds to the Asprosin chain, was initially thought to constitute a propeptide. Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin, an essential step for incorporation of Fibrillin-1 into the nascent microfibrils. [Fibrillin-1]: Forms intermolecular disulfide bonds either with other fibrillin-1 molecules or with other components of the microfibrils. O-glycosylated on serine residues by POGLUT2 and POGLUT3 which is necessary for efficient protein secretion. Neonatal lethality due to ruptured aortic aneurysm, impaired pulmonary function and/or diaphragmatic collapse. Neonatal aorta show a disorganized and poorly developed medial layer but normal levels of elastin cross-links. [Asprosin]: Mice lacking Asprosin show low appetite, reduced adiposity and protection from diet-induced obesity. [Asprosin]: Attractive therapeutic target for type II diabetes and metabolic syndrome (PubMed:33904407). Inactivation by monoclonal antibodies that recognize unique Asprosin epitopes reduces appetite, body weight and blood glucose levels in mice with metabolic syndrome, leading to mitigate metabolic syndrome (PubMed:33904407). Belongs to the fibrillin family. skeletal system development microfibril metanephros development kidney development integrin binding hormone activity extracellular matrix structural constituent calcium ion binding protein binding extracellular region basement membrane extracellular space glucose metabolic process heart development heparin binding protein kinase A signaling extracellular matrix cell adhesion mediated by integrin activation of protein kinase A activity sequestering of BMP in extracellular matrix sequestering of TGFbeta in extracellular matrix glucose homeostasis identical protein binding camera-type eye development macromolecular complex binding negative regulation of osteoclast differentiation embryonic eye morphogenesis post-embryonic eye morphogenesis cellular response to transforming growth factor beta stimulus cellular response to insulin-like growth factor stimulus negative regulation of osteoclast development uc008mcq.1 uc008mcq.2 uc008mcq.3 
ENSMUST00000103239.10 Sema6d ENSMUST00000103239.10 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, transcript variant 4 (from RefSeq NM_199241.4) A2AW72 ENSMUST00000103239.1 ENSMUST00000103239.2 ENSMUST00000103239.3 ENSMUST00000103239.4 ENSMUST00000103239.5 ENSMUST00000103239.6 ENSMUST00000103239.7 ENSMUST00000103239.8 ENSMUST00000103239.9 Kiaa1479 NM_199241 Q76KF0 Q76KF1 Q76KF2 Q76KF3 Q76KF4 Q80TD0 SEM6D_MOUSE uc290aby.1 uc290aby.2 Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections (By similarity). Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=6; Name=4; IsoId=Q76KF0-1; Sequence=Displayed; Name=1; IsoId=Q76KF0-2; Sequence=VSP_016568, VSP_016569; Name=2; IsoId=Q76KF0-3; Sequence=VSP_016569; Name=3; IsoId=Q76KF0-4; Sequence=VSP_016571; Name=5; IsoId=Q76KF0-5; Sequence=VSP_016568, VSP_016571; Name=6; IsoId=Q76KF0-6; Sequence=VSP_016570; Expressed in brain and lung. Belongs to the semaphorin family. Sequence=BAC65797.1; Type=Erroneous initiation; Evidence=; neural crest cell migration protein binding extracellular space cytoplasm Golgi apparatus plasma membrane integral component of plasma membrane multicellular organism development nervous system development cell surface positive regulation of smooth muscle cell migration negative regulation of smooth muscle cell migration membrane integral component of membrane ventricular system development cell differentiation semaphorin receptor binding positive regulation of cell migration negative regulation of axon extension chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway uc290aby.1 uc290aby.2 
ENSMUST00000103242.5 Tmem97 ENSMUST00000103242.5 transmembrane protein 97 (from RefSeq NM_133706.2) ENSMUST00000103242.1 ENSMUST00000103242.2 ENSMUST00000103242.3 ENSMUST00000103242.4 NM_133706 Q8VD00 S2r SGMR2_MOUSE uc007kjv.1 uc007kjv.2 uc007kjv.3 Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. Interacts with NPC1. Nucleus membrane ; Multi-pass membrane protein Rough endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Localized at cell membrane and in lysosomes in sterol-depleted cells when expression of endogenous TMEM97 is stimulated. Sigma receptors are classified into two subtypes (Sigma- 1 and Sigma-2) based on their different pharmacological profile. Sigma- 2 receptors are identified by radioligand-binding studies as a binding site with high affinity for di-o-tolylguanidine (DTG) and haloperidol. Belongs to the TMEM97/sigma-2 receptor family. molecular_function nucleus lysosome endoplasmic reticulum rough endoplasmic reticulum cytosol plasma membrane membrane integral component of membrane rough endoplasmic reticulum membrane nuclear membrane cholesterol homeostasis uc007kjv.1 uc007kjv.2 uc007kjv.3 
ENSMUST00000103245.3 Mir761 ENSMUST00000103245.3 microRNA 761 (from RefSeq NR_030432.1) ENSMUST00000103245.1 ENSMUST00000103245.2 NR_030432 uc012dii.1 uc012dii.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012dii.1 uc012dii.2 
ENSMUST00000103249.3 Mir763 ENSMUST00000103249.3 microRNA 763 (from RefSeq NR_030434.1) ENSMUST00000103249.1 ENSMUST00000103249.2 NR_030434 uc056yio.1 uc056yio.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yio.1 uc056yio.2 
ENSMUST00000103251.3 Mir804 ENSMUST00000103251.3 microRNA 804 (from RefSeq NR_030529.1) ENSMUST00000103251.1 ENSMUST00000103251.2 NR_030529 uc011xuh.1 uc011xuh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011xuh.1 uc011xuh.2 
ENSMUST00000103252.3 Mir770 ENSMUST00000103252.3 microRNA 770 (from RefSeq NR_030427.1) ENSMUST00000103252.1 ENSMUST00000103252.2 NR_030427 uc011ysc.1 uc011ysc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609657.1 [ECO:0000345] ##Evidence-Data-END## uc011ysc.1 uc011ysc.2 
ENSMUST00000103254.3 Mir759 ENSMUST00000103254.3 microRNA 759 (from RefSeq NR_030436.1) ENSMUST00000103254.1 ENSMUST00000103254.2 NR_030436 uc011zoz.1 uc011zoz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011zoz.1 uc011zoz.2 
ENSMUST00000103255.3 Mir762 ENSMUST00000103255.3 microRNA 762 (from RefSeq NR_030428.1) ENSMUST00000103255.1 ENSMUST00000103255.2 NR_030428 uc012ful.1 uc012ful.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc012ful.1 uc012ful.2 
ENSMUST00000103256.3 Mir767 ENSMUST00000103256.3 microRNA 767 (from RefSeq NR_035528.1) ENSMUST00000103256.1 ENSMUST00000103256.2 NR_035528 uc012hjw.1 uc012hjw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012hjw.1 uc012hjw.2 
ENSMUST00000103257.3 Mir760 ENSMUST00000103257.3 microRNA 760 (from RefSeq NR_030439.1) ENSMUST00000103257.1 ENSMUST00000103257.2 NR_030439 uc012cwz.1 uc012cwz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609674.1 [ECO:0000345] ##Evidence-Data-END## uc012cwz.1 uc012cwz.2 
ENSMUST00000103258.3 Mir802 ENSMUST00000103258.3 microRNA 802 (from RefSeq NR_030429.1) ENSMUST00000103258.1 ENSMUST00000103258.2 NR_030429 uc012aio.1 uc012aio.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609660.1 [ECO:0000345] ##Evidence-Data-END## uc012aio.1 uc012aio.2 
ENSMUST00000103259.3 Mir764 ENSMUST00000103259.3 microRNA 764 (from RefSeq NR_030433.1) ENSMUST00000103259.1 ENSMUST00000103259.2 NR_030433 uc012hpz.1 uc012hpz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609664.1 [ECO:0000345] ##Evidence-Data-END## uc012hpz.1 uc012hpz.2 
ENSMUST00000103260.3 Mir758 ENSMUST00000103260.3 microRNA 758 (from RefSeq NR_030421.1) ENSMUST00000103260.1 ENSMUST00000103260.2 NR_030421 uc011yte.1 uc011yte.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609648.1 [ECO:0000345] ##Evidence-Data-END## uc011yte.1 uc011yte.2 
ENSMUST00000103261.3 Mir744 ENSMUST00000103261.3 microRNA 744 (from RefSeq NR_030417.1) ENSMUST00000103261.1 ENSMUST00000103261.2 NR_030417 uc011xwj.1 uc011xwj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609644.1 [ECO:0000345] ##Evidence-Data-END## uc011xwj.1 uc011xwj.2 
ENSMUST00000103262.3 Trbv1 ENSMUST00000103262.3 Trbv1 (from geneSymbol) A0A0B4J1G7 A0A0B4J1G7_MOUSE AK138971 ENSMUST00000103262.1 ENSMUST00000103262.2 Trbv1 uc029vuj.1 uc029vuj.2 uc029vuj.3 peptide antigen binding uc029vuj.1 uc029vuj.2 uc029vuj.3 
ENSMUST00000103263.3 Trbv2 ENSMUST00000103263.3 Trbv2 (from geneSymbol) A0A0B4J1G8 A0A0B4J1G8_MOUSE ENSMUST00000103263.1 ENSMUST00000103263.2 M16121 Trbv2 uc009bnp.1 uc009bnp.2 uc009bnp.3 uc009bnp.1 uc009bnp.2 uc009bnp.3 
ENSMUST00000103264.3 Trbv3 ENSMUST00000103264.3 Trbv3 (from geneSymbol) A0A0A6YYE2 A0A0A6YYE2_MOUSE ENSMUST00000103264.1 ENSMUST00000103264.2 Trbv3 X03865 uc291dub.1 uc291dub.2 uc291dub.1 uc291dub.2 
ENSMUST00000103265.5 Trbv4 ENSMUST00000103265.5 Trbv4 (from geneSymbol) A0A075B5I2 A0A075B5I2_MOUSE ENSMUST00000103265.1 ENSMUST00000103265.2 ENSMUST00000103265.3 ENSMUST00000103265.4 Trbv4 X56714 uc009bns.1 uc009bns.2 uc009bns.3 uc009bns.1 uc009bns.2 uc009bns.3 
ENSMUST00000103266.3 Trbv5 ENSMUST00000103266.3 Trbv5 (from geneSymbol) A0A0B4J1G9 A0A0B4J1G9_MOUSE ENSMUST00000103266.1 ENSMUST00000103266.2 M11456 Trbv5 uc291duc.1 uc291duc.2 uc291duc.1 uc291duc.2 
ENSMUST00000103267.3 Trbv12-1 ENSMUST00000103267.3 Trbv12-1 (from geneSymbol) A0A0B4J1H0 A0A0B4J1H0_MOUSE ENSMUST00000103267.1 ENSMUST00000103267.2 M30881 Trbv12-1 uc009bnw.1 uc009bnw.2 uc009bnw.1 uc009bnw.2 
ENSMUST00000103269.3 Trbv12-2 ENSMUST00000103269.3 Trbv12-2 (from geneSymbol) A0A0B4J1H1 A0A0B4J1H1_MOUSE ENSMUST00000103269.1 ENSMUST00000103269.2 M13673 Trbv12-2 uc291dul.1 uc291dul.2 uc291dul.1 uc291dul.2 
ENSMUST00000103270.4 Trbv13-2 ENSMUST00000103270.4 Trbv13-2 (from geneSymbol) A0A140T8N6 A0A140T8N6_MOUSE DQ340294 ENSMUST00000103270.1 ENSMUST00000103270.2 ENSMUST00000103270.3 Trbv13-2 uc012ekn.1 uc012ekn.2 uc012ekn.3 cytokine-mediated signaling pathway uc012ekn.1 uc012ekn.2 uc012ekn.3 
ENSMUST00000103271.2 Trbv13-3 ENSMUST00000103271.2 Trbv13-3 (from geneSymbol) A0A0B4J1H2 A0A0B4J1H2_MOUSE ENSMUST00000103271.1 Trbv13-3 X06772 uc009boc.1 uc009boc.2 uc009boc.3 uc009boc.4 response to protozoan uc009boc.1 uc009boc.2 uc009boc.3 uc009boc.4 
ENSMUST00000103272.4 Trbv14 ENSMUST00000103272.4 Trbv14 (from geneSymbol) A0A140T8L9 A0A140T8L9_MOUSE ENSMUST00000103272.1 ENSMUST00000103272.2 ENSMUST00000103272.3 M31648 Trbv14 uc009bod.1 uc009bod.2 uc009bod.3 uc009bod.4 uc009bod.5 uc009bod.1 uc009bod.2 uc009bod.3 uc009bod.4 uc009bod.5 
ENSMUST00000103273.3 Trbv15 ENSMUST00000103273.3 Trbv15 (from geneSymbol) A0A0A6YYE3 A0A0A6YYE3_MOUSE BC030075 ENSMUST00000103273.1 ENSMUST00000103273.2 Trbv15 uc291dun.1 uc291dun.2 uc291dun.1 uc291dun.2 
ENSMUST00000103274.4 Trbv16 ENSMUST00000103274.4 Trbv16 (from geneSymbol) A0A0B4J1H3 A0A0B4J1H3_MOUSE ENSMUST00000103274.1 ENSMUST00000103274.2 ENSMUST00000103274.3 M15459 Trbv16 uc029vuq.1 uc029vuq.2 uc029vuq.3 uc029vuq.1 uc029vuq.2 uc029vuq.3 
ENSMUST00000103275.4 Trbv17 ENSMUST00000103275.4 Trbv17 (from geneSymbol) A0A140T8P8 A0A140T8P8_MOUSE ENSMUST00000103275.1 ENSMUST00000103275.2 ENSMUST00000103275.3 M13677 Trbv17 uc009boh.1 uc009boh.2 uc009boh.3 uc009boh.1 uc009boh.2 uc009boh.3 
ENSMUST00000103276.3 Trbv19 ENSMUST00000103276.3 Trbv19 (from geneSymbol) A0A0B4J1H4 A0A0B4J1H4_MOUSE ENSMUST00000103276.1 ENSMUST00000103276.2 M10093 Trbv19 uc009boj.1 uc009boj.2 uc009boj.3 uc009boj.4 uc009boj.1 uc009boj.2 uc009boj.3 uc009boj.4 
ENSMUST00000103277.2 Trbv20 ENSMUST00000103277.2 Trbv20 (from geneSymbol) A0A0B4J1H5 A0A0B4J1H5_MOUSE ENSMUST00000103277.1 M11859 Trbv20 uc009bol.1 uc009bol.2 uc009bol.3 uc009bol.1 uc009bol.2 uc009bol.3 
ENSMUST00000103281.3 Trbv29 ENSMUST00000103281.3 Trbv29 (from geneSymbol) A0A0G2LB96 A0A0G2LB96_MOUSE ENSMUST00000103281.1 ENSMUST00000103281.2 Trbv29 U63547 uc012ekt.1 uc012ekt.2 uc012ekt.3 uc012ekt.1 uc012ekt.2 uc012ekt.3 
ENSMUST00000103284.2 Trbj1-1 ENSMUST00000103284.2 Trbj1-1 (from geneSymbol) A0A0A6YVY0 A0A0A6YVY0_MOUSE ENSMUST00000103284.1 Trbj1-1 uc291dvj.1 uc291dvj.2 uc291dvj.1 uc291dvj.2 
ENSMUST00000103285.2 Trbj1-2 ENSMUST00000103285.2 Trbj1-2 (from geneSymbol) A0A0A6YWU1 A0A0A6YWU1_MOUSE ENSMUST00000103285.1 FJ410989 Trbj1-2 uc291dvk.1 uc291dvk.2 uc291dvk.1 uc291dvk.2 
ENSMUST00000103287.2 Trbj1-4 ENSMUST00000103287.2 Trbj1-4 (from geneSymbol) A0A0A6YXY4 A0A0A6YXY4_MOUSE AK153842 ENSMUST00000103287.1 Trbj1-4 uc291dvn.1 uc291dvn.2 uc291dvn.1 uc291dvn.2 
ENSMUST00000103288.2 Trbj1-5 ENSMUST00000103288.2 Trbj1-5 (from geneSymbol) A0A0A6YX16 A0A0A6YX16_MOUSE AK153842 ENSMUST00000103288.1 Trbj1-5 uc291dvo.1 uc291dvo.2 uc291dvo.1 uc291dvo.2 
ENSMUST00000103289.2 Trbj1-6 ENSMUST00000103289.2 Trbj1-6 (from geneSymbol) A0A0A6YWT0 A0A0A6YWT0_MOUSE AK153842 ENSMUST00000103289.1 Trbj1-6 uc291dvp.1 uc291dvp.2 uc291dvp.1 uc291dvp.2 
ENSMUST00000103293.2 Trbj2-1 ENSMUST00000103293.2 Trbj2-1 (from geneSymbol) A0A0A6YWW0 A0A0A6YWW0_MOUSE ENSMUST00000103293.1 Trbj2-1 uc029vux.1 uc029vux.2 uc029vux.3 uc029vux.4 uc029vux.1 uc029vux.2 uc029vux.3 uc029vux.4 
ENSMUST00000103294.2 Trbj2-2 ENSMUST00000103294.2 Trbj2-2 (from geneSymbol) A0A0A6YX08 A0A0A6YX08_MOUSE AF158162 ENSMUST00000103294.1 Trbj2-2 uc291dvv.1 uc291dvv.2 uc291dvv.1 uc291dvv.2 
ENSMUST00000103295.2 Trbj2-3 ENSMUST00000103295.2 Trbj2-3 (from geneSymbol) A0A0B4J1P6 A0A0B4J1P6_MOUSE ENSMUST00000103295.1 Trbj2-3 uc291dvw.1 uc291dvw.2 uc291dvw.1 uc291dvw.2 
ENSMUST00000103296.2 Trbj2-4 ENSMUST00000103296.2 Trbj2-4 (from geneSymbol) A0A0B4J1P9 A0A0B4J1P9_MOUSE ENSMUST00000103296.1 GU599230 Trbj2-4 uc291dvx.1 uc291dvx.2 uc291dvx.1 uc291dvx.2 
ENSMUST00000103297.2 Trbj2-5 ENSMUST00000103297.2 Trbj2-5 (from geneSymbol) A0A0B4J1P2 A0A0B4J1P2_MOUSE ENSMUST00000103297.1 Trbj2-5 X55822 uc291dvy.1 uc291dvy.2 uc291dvy.1 uc291dvy.2 
ENSMUST00000103298.2 Trbj2-7 ENSMUST00000103298.2 Trbj2-7 (from geneSymbol) A0A0A6YXH6 A0A0A6YXH6_MOUSE ENSMUST00000103298.1 Trbj2-7 uc029vva.1 uc029vva.2 uc029vva.3 uc029vva.1 uc029vva.2 uc029vva.3 
ENSMUST00000103299.3 Trbc2 ENSMUST00000103299.3 Trbc2 (from geneSymbol) A0A075B5J4 A0A075B5J4_MOUSE BC034887 ENSMUST00000103299.1 ENSMUST00000103299.2 Trbc2 uc291dvz.1 uc291dvz.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane membrane integral component of membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc291dvz.1 uc291dvz.2 
ENSMUST00000103301.3 Gm20730 ENSMUST00000103301.3 Gm20730 (from geneSymbol) A0A075B5J6 A0A075B5J6_MOUSE ENSMUST00000103301.1 ENSMUST00000103301.2 Gm20730 uc012ekz.1 uc012ekz.2 uc012ekz.3 immunoglobulin production extracellular space immune response uc012ekz.1 uc012ekz.2 uc012ekz.3 
ENSMUST00000103302.3 Igkv2-137 ENSMUST00000103302.3 Igkv2-137 (from geneSymbol) A0A0B4J1H6 A0A0B4J1H6_MOUSE AJ555479 ENSMUST00000103302.1 ENSMUST00000103302.2 Igkv2-137 uc291ffr.1 uc291ffr.2 immunoglobulin production extracellular space immune response response to bacterium uc291ffr.1 uc291ffr.2 
ENSMUST00000103303.3 Igkv1-135 ENSMUST00000103303.3 Igkv1-135 (from geneSymbol) A0A0B4J1H7 A0A0B4J1H7_MOUSE ENSMUST00000103303.1 ENSMUST00000103303.2 Igkv1-135 M20830 uc291fft.1 uc291fft.2 immunoglobulin production extracellular space immune response uc291fft.1 uc291fft.2 
ENSMUST00000103304.3 Igkv1-133 ENSMUST00000103304.3 Igkv1-133 (from geneSymbol) A0A0B4J1H8 A0A0B4J1H8_MOUSE ENSMUST00000103304.1 ENSMUST00000103304.2 Igkv1-133 Z17401 uc291ffy.1 uc291ffy.2 immunoglobulin production extracellular space immune response uc291ffy.1 uc291ffy.2 
ENSMUST00000103305.2 Igkv1-132 ENSMUST00000103305.2 Igkv1-132 (from geneSymbol) A0A0B4J1H9 A0A0B4J1H9_MOUSE ENSMUST00000103305.1 Igkv1-132 uc291fgc.1 uc291fgc.2 immunoglobulin production extracellular space immune response uc291fgc.1 uc291fgc.2 
ENSMUST00000103306.2 Igkv1-131 ENSMUST00000103306.2 Igkv1-131 (from geneSymbol) A0A140T8M8 A0A140T8M8_MOUSE ENSMUST00000103306.1 Igkv1-131 uc291fgd.1 uc291fgd.2 immunoglobulin production extracellular space immune response uc291fgd.1 uc291fgd.2 
ENSMUST00000103310.3 Igkv14-126 ENSMUST00000103310.3 Igkv14-126 (from geneSymbol) A0A075B5K0 A0A075B5K0_MOUSE BC055906 ENSMUST00000103310.1 ENSMUST00000103310.2 Igkv14-126 uc291fgq.1 uc291fgq.2 immunoglobulin production extracellular space immune response uc291fgq.1 uc291fgq.2 
ENSMUST00000103313.3 Igkv9-123 ENSMUST00000103313.3 Igkv9-123 (from geneSymbol) A0A140T8N8 A0A140T8N8_MOUSE ENSMUST00000103313.1 ENSMUST00000103313.2 Igkv9-123 M20832 uc291fgw.1 uc291fgw.2 immunoglobulin production extracellular space immune response uc291fgw.1 uc291fgw.2 
ENSMUST00000103314.3 Igkv1-122 ENSMUST00000103314.3 Igkv1-122 (from geneSymbol) A0A140T8M9 A0A140T8M9_MOUSE AF013576 ENSMUST00000103314.1 ENSMUST00000103314.2 Igkv1-122 uc291fgx.1 uc291fgx.2 immunoglobulin production extracellular space immune response uc291fgx.1 uc291fgx.2 
ENSMUST00000103316.2 Igkv9-120 ENSMUST00000103316.2 Igkv9-120 (from geneSymbol) A0A140T8N0 A0A140T8N0_MOUSE ENSMUST00000103316.1 EU330530 Igkv9-120 uc291fha.1 uc291fha.2 uc291fha.1 uc291fha.2 
ENSMUST00000103317.3 Igkv1-117 ENSMUST00000103317.3 Igkv1-117 (from geneSymbol) A0A140T8M0 A0A140T8M0_MOUSE AB453397 ENSMUST00000103317.1 ENSMUST00000103317.2 Igkv1-117 uc291fhh.1 uc291fhh.2 immunoglobulin production extracellular space immune response uc291fhh.1 uc291fhh.2 
ENSMUST00000103318.6 Igkv2-112 ENSMUST00000103318.6 Igkv2-112 (from geneSymbol) ENSMUST00000103318.1 ENSMUST00000103318.2 ENSMUST00000103318.3 ENSMUST00000103318.4 ENSMUST00000103318.5 Gm5153 Igkv2-112 KV2A2_MOUSE M19910 P01627 uc291fhp.1 uc291fhp.2 adaptive immune response immune system process immunoglobulin production extracellular space immune response immunoglobulin complex uc291fhp.1 uc291fhp.2 
ENSMUST00000103320.3 Igkv14-111 ENSMUST00000103320.3 Igkv14-111 (from geneSymbol) A0A140T8P9 A0A140T8P9_MOUSE ENSMUST00000103320.1 ENSMUST00000103320.2 GU724340 Igkv14-111 uc291fhr.1 uc291fhr.2 immunoglobulin production extracellular space immune response uc291fhr.1 uc291fhr.2 
ENSMUST00000103321.3 Igkv1-110 ENSMUST00000103321.3 Igkv1-110 (from geneSymbol) A0A0B4J1I0 A0A0B4J1I0_MOUSE BC019760 ENSMUST00000103321.1 ENSMUST00000103321.2 Igkv1-110 uc291fht.1 uc291fht.2 immunoglobulin production extracellular space immune response uc291fht.1 uc291fht.2 
ENSMUST00000103322.3 Igkv2-109 ENSMUST00000103322.3 Igkv2-109 (from geneSymbol) A0A075B5K6 A0A075B5K6_MOUSE ENSMUST00000103322.1 ENSMUST00000103322.2 Igkv2-109 Z49934 uc291fhw.1 uc291fhw.2 immunoglobulin production extracellular space immune response uc291fhw.1 uc291fhw.2 
ENSMUST00000103323.3 Igkv16-104 ENSMUST00000103323.3 Igkv16-104 (from geneSymbol) A0A0B4J1I1 A0A0B4J1I1_MOUSE ENSMUST00000103323.1 ENSMUST00000103323.2 Igkv16-104 M19911 uc291fic.1 uc291fic.2 immunoglobulin production extracellular space immune response uc291fic.1 uc291fic.2 
ENSMUST00000103324.3 Igkv15-103 ENSMUST00000103324.3 Igkv15-103 (from geneSymbol) A0A140T8P3 A0A140T8P3_MOUSE ENSMUST00000103324.1 ENSMUST00000103324.2 Igkv15-103 M19908 uc291fid.1 uc291fid.2 immunoglobulin production extracellular space immune response uc291fid.1 uc291fid.2 
ENSMUST00000103328.3 Igkv10-96 ENSMUST00000103328.3 Igkv10-96 (from geneSymbol) A0A140T8M1 A0A140T8M1_MOUSE ENSMUST00000103328.1 ENSMUST00000103328.2 Igkv10-96 JF412710 uc291fiq.1 uc291fiq.2 immunoglobulin production extracellular space immune response uc291fiq.1 uc291fiq.2 
ENSMUST00000103330.2 Igkv10-94 ENSMUST00000103330.2 Igkv10-94 (from geneSymbol) A0A075B5L1 A0A075B5L1_MOUSE E07922 ENSMUST00000103330.1 Igkv10-94 uc291fiv.1 uc291fiv.2 immunoglobulin production extracellular space immune response uc291fiv.1 uc291fiv.2 
ENSMUST00000103332.2 Igkv4-92 ENSMUST00000103332.2 Igkv4-92 (from geneSymbol) A0A0B4J1I2 A0A0B4J1I2_MOUSE ENSMUST00000103332.1 Igkv4-92 uc291fja.1 uc291fja.2 immunoglobulin production extracellular space immune response uc291fja.1 uc291fja.2 
ENSMUST00000103333.4 Igkv4-91 ENSMUST00000103333.4 Igkv4-91 (from geneSymbol) A0A075B5L2 A0A075B5L2_MOUSE AJ007954 ENSMUST00000103333.1 ENSMUST00000103333.2 ENSMUST00000103333.3 Igkv4-91 uc291fjc.1 uc291fjc.2 immunoglobulin production extracellular space immune response uc291fjc.1 uc291fjc.2 
ENSMUST00000103334.4 Igkv4-90 ENSMUST00000103334.4 Igkv4-90 (from geneSymbol) A0A075B5L3 A0A075B5L3_MOUSE DQ372793 ENSMUST00000103334.1 ENSMUST00000103334.2 ENSMUST00000103334.3 Igkv4-90 uc291fjd.1 uc291fjd.2 immunoglobulin production extracellular space immune response uc291fjd.1 uc291fjd.2 
ENSMUST00000103336.2 Igkv1-88 ENSMUST00000103336.2 Igkv1-88 (from geneSymbol) A0A140T8N1 A0A140T8N1_MOUSE ENSMUST00000103336.1 Igkv1-88 U16688 uc291fjh.1 uc291fjh.2 immunoglobulin production extracellular space immune response uc291fjh.1 uc291fjh.2 
ENSMUST00000103339.2 Igkv13-84 ENSMUST00000103339.2 Igkv13-84 (from geneSymbol) A0A140T8N3 A0A140T8N3_MOUSE AY704179 ENSMUST00000103339.1 Igkv13-84 uc291fjq.1 uc291fjq.2 immunoglobulin production extracellular space immune response uc291fjq.1 uc291fjq.2 
ENSMUST00000103341.4 Igkv4-80 ENSMUST00000103341.4 Igkv4-80 (from geneSymbol) A0A075B5L7 A0A075B5L7_MOUSE AB048522 ENSMUST00000103341.1 ENSMUST00000103341.2 ENSMUST00000103341.3 Igkv4-80 uc291fjw.1 uc291fjw.2 immunoglobulin production extracellular space immune response uc291fjw.1 uc291fjw.2 
ENSMUST00000103342.4 Igkv4-79 ENSMUST00000103342.4 Igkv4-79 (from geneSymbol) A0A075B5L8 A0A075B5L8_MOUSE DQ372744 ENSMUST00000103342.1 ENSMUST00000103342.2 ENSMUST00000103342.3 Igkv4-79 uc291fjx.1 uc291fjx.2 immunoglobulin production extracellular space immune response uc291fjx.1 uc291fjx.2 
ENSMUST00000103343.4 Igkv4-78 ENSMUST00000103343.4 Igkv4-78 (from geneSymbol) A0A0A6YYE5 A0A0A6YYE5_MOUSE ENSMUST00000103343.1 ENSMUST00000103343.2 ENSMUST00000103343.3 Igkv4-78 M20834 uc291fjz.1 uc291fjz.2 immunoglobulin production extracellular space immune response uc291fjz.1 uc291fjz.2 
ENSMUST00000103344.3 Igkv4-74 ENSMUST00000103344.3 Igkv4-74 (from geneSymbol) A0A0B4J1I3 A0A0B4J1I3_MOUSE ENSMUST00000103344.1 ENSMUST00000103344.2 Igkv4-74 X79906 uc291fkf.1 uc291fkf.2 immunoglobulin production extracellular space immune response uc291fkf.1 uc291fkf.2 
ENSMUST00000103345.4 Igkv4-51 ENSMUST00000103345.4 Igkv4-51 (from geneSymbol) A0A0A6YYE6 A0N8I8 A0N8I8_MOUSE ENSMUST00000103345.1 ENSMUST00000103345.2 ENSMUST00000103345.3 Igkv4-51 uc291flw.1 uc291flw.2 immunoglobulin production extracellular space immune response uc291flw.1 uc291flw.2 
ENSMUST00000103346.3 Igkv4-72 ENSMUST00000103346.3 Igkv4-72 (from geneSymbol) A0A0B4J1I4 A0A0B4J1I4_MOUSE ENSMUST00000103346.1 ENSMUST00000103346.2 Igkv4-72 S76823 uc291fki.1 uc291fki.2 immunoglobulin production extracellular space immune response uc291fki.1 uc291fki.2 
ENSMUST00000103348.3 Igkv4-70 ENSMUST00000103348.3 Igkv4-70 (from geneSymbol) A0A0B4J1I5 A0A0B4J1I5_MOUSE AJ416331 ENSMUST00000103348.1 ENSMUST00000103348.2 Igkv4-70 uc291fkm.1 uc291fkm.2 immunoglobulin production extracellular space immune response uc291fkm.1 uc291fkm.2 
ENSMUST00000103349.2 Igkv4-69 ENSMUST00000103349.2 Igkv4-69 (from geneSymbol) A0A0B4J1I6 A0A0B4J1I6_MOUSE DQ372802 ENSMUST00000103349.1 Igkv4-69 uc291fkn.1 uc291fkn.2 immunoglobulin production extracellular space immune response uc291fkn.1 uc291fkn.2 
ENSMUST00000103350.3 Igkv4-68 ENSMUST00000103350.3 Igkv4-68 (from geneSymbol) A0A0B4J1I7 A0A0B4J1I7_MOUSE ENSMUST00000103350.1 ENSMUST00000103350.2 Igkv4-68 M19905 uc291fko.1 uc291fko.2 immunoglobulin production extracellular space immune response uc291fko.1 uc291fko.2 
ENSMUST00000103354.3 Igkv4-59 ENSMUST00000103354.3 Igkv4-59 (from geneSymbol) A0A0B4J1I8 A0A0B4J1I8_MOUSE ENSMUST00000103354.1 ENSMUST00000103354.2 Igkv4-59 M12767 uc291flc.1 uc291flc.2 immunoglobulin production extracellular space immune response uc291flc.1 uc291flc.2 
ENSMUST00000103356.4 Igkv4-57-1 ENSMUST00000103356.4 Igkv4-57-1 (from geneSymbol) A0A075B5M4 A0A075B5M4_MOUSE ENSMUST00000103356.1 ENSMUST00000103356.2 ENSMUST00000103356.3 Igkv4-57-1 J04610 uc291flj.1 uc291flj.2 immunoglobulin production extracellular space immune response uc291flj.1 uc291flj.2 
ENSMUST00000103357.4 Igkv4-57 ENSMUST00000103357.4 Igkv4-57 (from geneSymbol) A0A0A6YYE7 A0A0A6YYE7_MOUSE ENSMUST00000103357.1 ENSMUST00000103357.2 ENSMUST00000103357.3 Igkv4-57 M28250 uc291fll.1 uc291fll.2 immunoglobulin production extracellular space immune response uc291fll.1 uc291fll.2 
ENSMUST00000103359.3 Igkv4-55 ENSMUST00000103359.3 Igkv4-55 (from geneSymbol) A0A0B4J1I9 A0A0B4J1I9_MOUSE ENSMUST00000103359.1 ENSMUST00000103359.2 Igkv4-55 M19906 uc291flp.1 uc291flp.2 uc291flp.1 uc291flp.2 
ENSMUST00000103363.2 Igkv4-50 ENSMUST00000103363.2 Igkv4-50 (from geneSymbol) A0A0B4J1J0 A0A0B4J1J0_MOUSE ENSMUST00000103363.1 Igkv4-50 M19912 uc291fly.1 uc291fly.2 immunoglobulin production extracellular space immune response uc291fly.1 uc291fly.2 
ENSMUST00000103364.3 Igkv5-48 ENSMUST00000103364.3 There appears to be two possible splice junctions at the 3' end of the intron. The alternate would code for a protein lacking residues 17-19. (from UniProt P01642) BC106172 ENSMUST00000103364.1 ENSMUST00000103364.2 Gm10881 KV5A9_MOUSE P01642 uc291fma.1 uc291fma.2 There appears to be two possible splice junctions at the 3' end of the intron. The alternate would code for a protein lacking residues 17-19. adaptive immune response immune system process immunoglobulin production extracellular space immune response immunoglobulin complex uc291fma.1 uc291fma.2 
ENSMUST00000103365.3 Igkv12-46 ENSMUST00000103365.3 Igkv12-46 (from geneSymbol) A0A140T8P6 A0A140T8P6_MOUSE ENSMUST00000103365.1 ENSMUST00000103365.2 Igkv12-46 S44584 uc291fmc.1 uc291fmc.2 immunoglobulin production extracellular space immune response uc291fmc.1 uc291fmc.2 
ENSMUST00000103366.3 Igkv5-45 ENSMUST00000103366.3 Igkv5-45 (from geneSymbol) A0A0B4J1J1 A0A0B4J1J1_MOUSE ENSMUST00000103366.1 ENSMUST00000103366.2 Igkv5-45 X14625 uc291fmd.1 uc291fmd.2 immunoglobulin production extracellular space immune response uc291fmd.1 uc291fmd.2 
ENSMUST00000103367.3 Igkv12-44 ENSMUST00000103367.3 Igkv12-44 (from geneSymbol) A0A140T8M2 A0A140T8M2_MOUSE ENSMUST00000103367.1 ENSMUST00000103367.2 Igkv12-44 S61689 uc291fme.1 uc291fme.2 immunoglobulin production extracellular space immune response uc291fme.1 uc291fme.2 
ENSMUST00000103368.3 Igkv5-43 ENSMUST00000103368.3 Igkv5-43 (from geneSymbol) A0A0B4J1J2 A0A0B4J1J2_MOUSE ENSMUST00000103368.1 ENSMUST00000103368.2 Igkv5-43 X14625 uc291fmf.1 uc291fmf.2 immunoglobulin production extracellular space immune response uc291fmf.1 uc291fmf.2 
ENSMUST00000103369.2 Igkv12-41 ENSMUST00000103369.2 The gene was isolated and sequenced separately from two different sources, embryos and cultured plasmacytoma cells that secrete the similar kappa chain MOPC 149. (from UniProt P01635) AY081856 ENSMUST00000103369.1 Gm16848 Igkv12-41 KV5A3_MOUSE P01635 uc291fmh.1 uc291fmh.2 The gene was isolated and sequenced separately from two different sources, embryos and cultured plasmacytoma cells that secrete the similar kappa chain MOPC 149. adaptive immune response immune system process immunoglobulin production extracellular space immune response immunoglobulin complex uc291fmh.1 uc291fmh.2 
ENSMUST00000103372.3 Igkv5-37 ENSMUST00000103372.3 Igkv5-37 (from geneSymbol) A0A140T8N4 A0A140T8N4_MOUSE ENSMUST00000103372.1 ENSMUST00000103372.2 Igkv5-37 Z17400 uc291fmp.1 uc291fmp.2 immunoglobulin production extracellular space immune response uc291fmp.1 uc291fmp.2 
ENSMUST00000103377.3 Igkv6-32 ENSMUST00000103377.3 Igkv6-32 (from geneSymbol) A0A140T8N9 A0A140T8N9_MOUSE ENSMUST00000103377.1 ENSMUST00000103377.2 Igkv6-32 LC110289 uc291fmz.1 uc291fmz.2 immunoglobulin production extracellular space immune response uc291fmz.1 uc291fmz.2 
ENSMUST00000103378.3 Igkv8-30 ENSMUST00000103378.3 Igkv8-30 (from geneSymbol) A0A140T8M3 A0A140T8M3_MOUSE AB050076 ENSMUST00000103378.1 ENSMUST00000103378.2 Igkv8-30 uc291fnb.1 uc291fnb.2 immunoglobulin production extracellular space immune response uc291fnb.1 uc291fnb.2 
ENSMUST00000103382.2 Igkv8-26 ENSMUST00000103382.2 Igkv8-26 (from geneSymbol) A0A075B5N5 A0A075B5N5_MOUSE ENSMUST00000103382.1 Igkv8-26 uc291fnk.1 uc291fnk.2 immunoglobulin production extracellular space immune response uc291fnk.1 uc291fnk.2 
ENSMUST00000103383.3 Igkv6-25 ENSMUST00000103383.3 Igkv6-25 (from geneSymbol) A0A140T8N7 A0A140T8N7_MOUSE ENSMUST00000103383.1 ENSMUST00000103383.2 Igkv6-25 X05877 uc291fnm.1 uc291fnm.2 immunoglobulin production extracellular space immune response uc291fnm.1 uc291fnm.2 
ENSMUST00000103384.2 Igkv8-24 ENSMUST00000103384.2 Igkv8-24 (from geneSymbol) A0A140T8P5 A0A140T8P5_MOUSE ENSMUST00000103384.1 Igkv8-24 U01356 uc291fnn.1 uc291fnn.2 immunoglobulin production extracellular space immune response uc291fnn.1 uc291fnn.2 
ENSMUST00000103386.3 Igkv6-23 ENSMUST00000103386.3 Igkv6-23 (from geneSymbol) A0A140T8N5 A0A140T8N5_MOUSE ENSMUST00000103386.1 ENSMUST00000103386.2 Igkv6-23 K02156 uc291fnp.1 uc291fnp.2 immunoglobulin production extracellular space immune response uc291fnp.1 uc291fnp.2 
ENSMUST00000103387.3 Igkv8-21 ENSMUST00000103387.3 Igkv8-21 (from geneSymbol) A0A140T8P7 A0A140T8P7_MOUSE ENSMUST00000103387.1 ENSMUST00000103387.2 Igkv8-21 U97570 uc291fnt.1 uc291fnt.2 immunoglobulin production extracellular space immune response uc291fnt.1 uc291fnt.2 
ENSMUST00000103388.4 Igkv6-20 ENSMUST00000103388.4 Igkv6-20 (from geneSymbol) A0A140T8P2 A0A140T8P2_MOUSE ENSMUST00000103388.1 ENSMUST00000103388.2 ENSMUST00000103388.3 Igkv6-20 uc291fnv.1 uc291fnv.2 immunoglobulin production extracellular space immune response uc291fnv.1 uc291fnv.2 
ENSMUST00000103390.3 Igkv8-18 ENSMUST00000103390.3 Igkv8-18 (from geneSymbol) A0A0B4J1J3 A0A0B4J1J3_MOUSE ENSMUST00000103390.1 ENSMUST00000103390.2 Igkv8-18 uc291fny.1 uc291fny.2 immunoglobulin production extracellular space immune response uc291fny.1 uc291fny.2 
ENSMUST00000103391.4 Igkv6-17 ENSMUST00000103391.4 Igkv6-17 (from geneSymbol) A0A140T8Q3 A0A140T8Q3_MOUSE ENSMUST00000103391.1 ENSMUST00000103391.2 ENSMUST00000103391.3 Igkv6-17 M19914 uc291foa.1 uc291foa.2 uc291foa.1 uc291foa.2 
ENSMUST00000103393.2 Igkv6-15 ENSMUST00000103393.2 Igkv6-15 (from geneSymbol) A0A140T8M5 A0A140T8M5_MOUSE AB049967 ENSMUST00000103393.1 Igkv6-15 uc291foe.1 uc291foe.2 immunoglobulin production extracellular space immune response uc291foe.1 uc291foe.2 
ENSMUST00000103394.2 Igkv6-14 ENSMUST00000103394.2 Igkv6-14 (from geneSymbol) A0A140T8P1 A0A140T8P1_MOUSE ENSMUST00000103394.1 Igkv6-14 X91669 uc291foi.1 uc291foi.2 immunoglobulin production extracellular space immune response response to bacterium uc291foi.1 uc291foi.2 
ENSMUST00000103396.2 Igkv3-12 ENSMUST00000103396.2 Igkv3-12 (from geneSymbol) A0A140T8P0 A0A140T8P0_MOUSE AB050082 ENSMUST00000103396.1 Igkv3-12 uc291foq.1 uc291foq.2 immunoglobulin production extracellular space immune response uc291foq.1 uc291foq.2 
ENSMUST00000103398.2 Igkv3-9 ENSMUST00000103398.2 Igkv3-9 (from geneSymbol) A0A140T8P4 A0A140T8P4_MOUSE ENSMUST00000103398.1 Igkv3-9 uc291fou.1 uc291fou.2 immunoglobulin production extracellular space immune response uc291fou.1 uc291fou.2 
ENSMUST00000103400.3 Igkv3-5 ENSMUST00000103400.3 Igkv3-5 (from geneSymbol) A0A140T8M6 A0A140T8M6_MOUSE ENSMUST00000103400.1 ENSMUST00000103400.2 Igkv3-5 M13698 uc291foz.1 uc291foz.2 immunoglobulin production extracellular space immune response uc291foz.1 uc291foz.2 
ENSMUST00000103401.3 Igkv3-4 ENSMUST00000103401.3 Igkv3-4 (from geneSymbol) A0A140T8Q4 A0A140T8Q4_MOUSE ENSMUST00000103401.1 ENSMUST00000103401.2 Igkv3-4 S50265 uc291fpa.1 uc291fpa.2 immunoglobulin production extracellular space immune response uc291fpa.1 uc291fpa.2 
ENSMUST00000103402.2 Igkv3-3 ENSMUST00000103402.2 Igkv3-3 (from geneSymbol) A0A140T8Q0 A0A140T8Q0_MOUSE ENSMUST00000103402.1 Igkv3-3 uc291fpb.1 uc291fpb.2 immunoglobulin production extracellular space immune response uc291fpb.1 uc291fpb.2 
ENSMUST00000103403.3 Igkv3-2 ENSMUST00000103403.3 Igkv3-2 (from geneSymbol) A0A075B5P0 A0A075B5P0_MOUSE AB050075 ENSMUST00000103403.1 ENSMUST00000103403.2 Igkv3-2 uc291fpc.1 uc291fpc.2 immunoglobulin production extracellular space immune response uc291fpc.1 uc291fpc.2 
ENSMUST00000103404.2 Igkv3-1 ENSMUST00000103404.2 Igkv3-1 (from geneSymbol) A0A075B5P1 A0A075B5P1_MOUSE AF013578 ENSMUST00000103404.1 Igkv3-1 uc291fpd.1 uc291fpd.2 immunoglobulin production extracellular space immune response uc291fpd.1 uc291fpd.2 
ENSMUST00000103405.2 Igkj1 ENSMUST00000103405.2 Igkj1 (from geneSymbol) A0A0G2JEZ6 A0A0G2JEZ6_MOUSE ENSMUST00000103405.1 Igkj1 M13409 uc291fpe.1 uc291fpe.2 response to lipopolysaccharide response to drug uc291fpe.1 uc291fpe.2 
ENSMUST00000103408.2 Igkj4 ENSMUST00000103408.2 Igkj4 (from geneSymbol) A0A0G2JFT5 A0A0G2JFT5_MOUSE ENSMUST00000103408.1 Igkj4 uc291fpj.1 uc291fpj.2 uc291fpj.1 uc291fpj.2 
ENSMUST00000103410.3 Igkc ENSMUST00000103410.3 Igkc (from geneSymbol) A0A5H1ZRK8 A0A5H1ZRK8_MOUSE BC002112 ENSMUST00000103410.1 ENSMUST00000103410.2 Igkc uc291fpm.1 uc291fpm.2 uc291fpm.1 uc291fpm.2 
ENSMUST00000103416.9 Ighg2c ENSMUST00000103416.9 Ighg2c (from geneSymbol) ENSMUST00000103416.1 ENSMUST00000103416.2 ENSMUST00000103416.3 ENSMUST00000103416.4 ENSMUST00000103416.5 ENSMUST00000103416.6 ENSMUST00000103416.7 ENSMUST00000103416.8 F6TQW2 F6TQW2_MOUSE Ighg2c KX431574 uc288jrh.1 uc288jrh.2 humoral immune response mediated by circulating immunoglobulin antigen binding extracellular space phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane membrane integral component of membrane immunoglobulin mediated immune response antibacterial humoral response immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jrh.1 uc288jrh.2 
ENSMUST00000103426.3 Ighm ENSMUST00000103426.3 Ighm (from geneSymbol) A0A075B5P6 A0A075B5P6_MOUSE BC099618 ENSMUST00000103426.1 ENSMUST00000103426.2 Ighm uc007pgt.1 uc007pgt.2 uc007pgt.3 uc007pgt.1 uc007pgt.2 uc007pgt.3 
ENSMUST00000103427.2 Ighj4 ENSMUST00000103427.2 Ighj4 (from geneSymbol) A0A0A6YXC7 A0A0A6YXC7_MOUSE AY205701 ENSMUST00000103427.1 Ighj4 uc288jrz.1 uc288jrz.2 uc288jrz.1 uc288jrz.2 
ENSMUST00000103428.2 Ighj3 ENSMUST00000103428.2 Ighj3 (from geneSymbol) A0A0A6YWW9 A0A0A6YWW9_MOUSE AY205895 ENSMUST00000103428.1 Ighj3 uc288jsa.1 uc288jsa.2 uc288jsa.1 uc288jsa.2 
ENSMUST00000103430.2 Ighj1 ENSMUST00000103430.2 Ighj1 (from geneSymbol) A0A0A6YVQ4 A0A0A6YVQ4_MOUSE AY205843 ENSMUST00000103430.1 Ighj1 uc288jsd.1 uc288jsd.2 uc288jsd.1 uc288jsd.2 
ENSMUST00000103439.2 Ighd1-1 ENSMUST00000103439.2 Ighd1-1 (from geneSymbol) A0A0G2JDD8 A0A0G2JDD8_MOUSE ENSMUST00000103439.1 Ighd1-1 uc288jsy.1 uc288jsy.2 uc288jsy.1 uc288jsy.2 
ENSMUST00000103441.2 Gm16968 ENSMUST00000103441.2 Gm16968 (from geneSymbol) A0A1Y7VHD7 A0A1Y7VHD7_MOUSE ENSMUST00000103441.1 Gm16968 uc288jtb.1 uc288jtb.2 uc288jtb.1 uc288jtb.2 
ENSMUST00000103443.3 Ighv2-2 ENSMUST00000103443.3 Ighv2-2 (from geneSymbol) A0A075B5P8 A0A075B5P8_MOUSE ENSMUST00000103443.1 ENSMUST00000103443.2 Ighv2-2 L23132 uc288jtf.1 uc288jtf.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jtf.1 uc288jtf.2 
ENSMUST00000103444.3 Ighv5-4 ENSMUST00000103444.3 Ighv5-4 (from geneSymbol) A0A075B5P9 A0A075B5P9_MOUSE AK156019 ENSMUST00000103444.1 ENSMUST00000103444.2 Ighv5-4 uc288jth.1 uc288jth.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jth.1 uc288jth.2 
ENSMUST00000103446.2 Ighv5-6 ENSMUST00000103446.2 Ighv5-6 (from geneSymbol) A0A075B5Q0 A0A075B5Q0_MOUSE ENSMUST00000103446.1 FN686798 Ighv5-6 uc288jtl.1 uc288jtl.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jtl.1 uc288jtl.2 
ENSMUST00000103447.2 Ighv2-4 ENSMUST00000103447.2 Ighv2-4 (from geneSymbol) A0A075B5Q1 A0A075B5Q1_MOUSE ENSMUST00000103447.1 Ighv2-4 JF430692 uc288jto.1 uc288jto.2 uc288jto.1 uc288jto.2 
ENSMUST00000103448.3 Ighv5-9 ENSMUST00000103448.3 Ighv5-9 (from geneSymbol) A0A075B5Q2 A0A075B5Q2_MOUSE ENSMUST00000103448.1 ENSMUST00000103448.2 Ighv5-9 X51721 uc288jtr.1 uc288jtr.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jtr.1 uc288jtr.2 
ENSMUST00000103450.4 Ighv5-12 ENSMUST00000103450.4 Ighv5-12 (from geneSymbol) A0A075B5Q4 A0A075B5Q4_MOUSE ENSMUST00000103450.1 ENSMUST00000103450.2 ENSMUST00000103450.3 Ighv5-12 U70449 uc288jtx.1 uc288jtx.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jtx.1 uc288jtx.2 
ENSMUST00000103451.5 Ighv2-9 ENSMUST00000103451.5 Ighv2-9 (from geneSymbol) A0A075B5Q5 A0A075B5Q5_MOUSE ENSMUST00000103451.1 ENSMUST00000103451.2 ENSMUST00000103451.3 ENSMUST00000103451.4 Ighv2-9 X15471 uc288juv.1 uc288juv.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288juv.1 uc288juv.2 
ENSMUST00000103456.4 Ighv2-7 ENSMUST00000103456.4 Ighv2-7 (from geneSymbol) A0A075B5Q8 A0A075B5Q8_MOUSE BC057688 ENSMUST00000103456.1 ENSMUST00000103456.2 ENSMUST00000103456.3 Ighv2-7 uc288jum.1 uc288jum.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jum.1 uc288jum.2 
ENSMUST00000103459.5 Ighv5-17 ENSMUST00000103459.5 Ighv5-17 (from geneSymbol) A0A075B5R1 A0A075B5R1_MOUSE BC010327 ENSMUST00000103459.1 ENSMUST00000103459.2 ENSMUST00000103459.3 ENSMUST00000103459.4 Ighv5-17 uc288jus.1 uc288jus.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jus.1 uc288jus.2 
ENSMUST00000103461.5 Ighv7-3 ENSMUST00000103461.5 Ighv7-3 (from geneSymbol) A0A075B5R2 A0A075B5R2_MOUSE AF045506 ENSMUST00000103461.1 ENSMUST00000103461.2 ENSMUST00000103461.3 ENSMUST00000103461.4 Ighv7-3 uc288jvt.1 uc288jvt.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jvt.1 uc288jvt.2 
ENSMUST00000103463.3 Ighv14-1 ENSMUST00000103463.3 Ighv14-1 (from geneSymbol) A0A075B5R4 A0A075B5R4_MOUSE BC092269 ENSMUST00000103463.1 ENSMUST00000103463.2 Ighv14-1 uc288jva.1 uc288jva.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jva.1 uc288jva.2 
ENSMUST00000103464.3 Ighv4-1 ENSMUST00000103464.3 Ighv4-1 (from geneSymbol) A0A075B5R5 A0A075B5R5_MOUSE AK035224 ENSMUST00000103464.1 ENSMUST00000103464.2 Ighv4-1 uc288jvb.1 uc288jvb.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jvb.1 uc288jvb.2 
ENSMUST00000103466.2 Ighv11-1 ENSMUST00000103466.2 Ighv11-1 (from geneSymbol) A0A075B5R6 A0A075B5R6_MOUSE D00078 ENSMUST00000103466.1 Ighv11-1 uc288jve.1 uc288jve.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jve.1 uc288jve.2 
ENSMUST00000103467.2 Ighv14-2 ENSMUST00000103467.2 Ighv14-2 (from geneSymbol) A0A075B5R7 A0A075B5R7_MOUSE ENSMUST00000103467.1 Ighv14-2 X02568 uc288jvf.1 uc288jvf.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jvf.1 uc288jvf.2 
ENSMUST00000103468.3 Ighv11-2 ENSMUST00000103468.3 Ighv11-2 (from geneSymbol) A0A075B5R8 A0A075B5R8_MOUSE ENSMUST00000103468.1 ENSMUST00000103468.2 Ighv11-2 M14839 uc288jvi.1 uc288jvi.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jvi.1 uc288jvi.2 
ENSMUST00000103469.4 Ighv14-3 ENSMUST00000103469.4 Ighv14-3 (from geneSymbol) A0A075B5R9 A0A075B5R9_MOUSE ENSMUST00000103469.1 ENSMUST00000103469.2 ENSMUST00000103469.3 Ighv14-3 M19570 uc288jvj.1 uc288jvj.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jvj.1 uc288jvj.2 
ENSMUST00000103472.4 Ighv9-2 ENSMUST00000103472.4 Ighv9-2 (from geneSymbol) A0A0B4J1J4 A0A0B4J1J4_MOUSE ENSMUST00000103472.1 ENSMUST00000103472.2 ENSMUST00000103472.3 Ighv9-2 uc288jvq.1 uc288jvq.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jvq.1 uc288jvq.2 
ENSMUST00000103473.2 Ighv9-3 ENSMUST00000103473.2 Ighv9-3 (from geneSymbol) A0A0B4J1J5 A0A0B4J1J5_MOUSE AF045504 ENSMUST00000103473.1 Ighv9-3 uc288jvs.1 uc288jvs.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jvs.1 uc288jvs.2 
ENSMUST00000103474.5 Ighv7-1 ENSMUST00000103474.5 Ighv7-1 (from geneSymbol) A0A075B5S2 A0A075B5S2_MOUSE ENSMUST00000103474.1 ENSMUST00000103474.2 ENSMUST00000103474.3 ENSMUST00000103474.4 Ighv7-1 L41874 uc288jux.1 uc288jux.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jux.1 uc288jux.2 
ENSMUST00000103478.4 Ighv3-1 ENSMUST00000103478.4 Ighv3-1 (from geneSymbol) A0A075B5S6 A0A075B5S6_MOUSE BC110346 ENSMUST00000103478.1 ENSMUST00000103478.2 ENSMUST00000103478.3 Ighv3-1 uc288jvc.1 uc288jvc.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jvc.1 uc288jvc.2 
ENSMUST00000103483.3 Ighv3-8 ENSMUST00000103483.3 Ighv3-8 (from geneSymbol) A0A075B5T0 A0A075B5T0_MOUSE ENSMUST00000103483.1 ENSMUST00000103483.2 EU835942 Ighv3-8 uc288jwn.1 uc288jwn.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jwn.1 uc288jwn.2 
ENSMUST00000103485.3 Ighv12-3 ENSMUST00000103485.3 Ighv12-3 (from geneSymbol) A0A075B5T1 A0A075B5T1_MOUSE ENSMUST00000103485.1 ENSMUST00000103485.2 Ighv12-3 M22439 uc288jws.1 uc288jws.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jws.1 uc288jws.2 
ENSMUST00000103486.2 Ighv6-3 ENSMUST00000103486.2 Ighv6-3 (from geneSymbol) A0A075B5T2 A0A075B5T2_MOUSE ENSMUST00000103486.1 Ighv6-3 M17726 uc288jwt.1 uc288jwt.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jwt.1 uc288jwt.2 
ENSMUST00000103489.2 Ighv6-6 ENSMUST00000103489.2 Ighv6-6 (from geneSymbol) A0A075B5T3 A0A075B5T3_MOUSE ENSMUST00000103489.1 Ighv6-6 M17167 uc288jwy.1 uc288jwy.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jwy.1 uc288jwy.2 
ENSMUST00000103492.2 Ighv10-1 ENSMUST00000103492.2 Ighv10-1 (from geneSymbol) A0A0B4J1J6 A0A0B4J1J6_MOUSE ENSMUST00000103492.1 Ighv10-1 M60022 uc288jxc.1 uc288jxc.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jxc.1 uc288jxc.2 
ENSMUST00000103493.3 Ighv1-4 ENSMUST00000103493.3 Ighv1-4 (from geneSymbol) A0A075B5T4 A0A075B5T4_MOUSE AF078547 ENSMUST00000103493.1 ENSMUST00000103493.2 Ighv1-4 uc288jxe.1 uc288jxe.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jxe.1 uc288jxe.2 
ENSMUST00000103495.3 Ighv10-3 ENSMUST00000103495.3 Ighv10-3 (from geneSymbol) A0A075B5T6 A0A075B5T6_MOUSE ENSMUST00000103495.1 ENSMUST00000103495.2 Ighv10-3 M60021 uc288jxi.1 uc288jxi.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jxi.1 uc288jxi.2 
ENSMUST00000103496.4 Ighv1-7 ENSMUST00000103496.4 Ighv1-7 (from geneSymbol) A0A075B5T7 A0A075B5T7_MOUSE AF045488 ENSMUST00000103496.1 ENSMUST00000103496.2 ENSMUST00000103496.3 Ighv1-7 uc288jxk.1 uc288jxk.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jxk.1 uc288jxk.2 
ENSMUST00000103501.3 Ighv1-16 ENSMUST00000103501.3 Ighv1-16 (from geneSymbol) A0A075B5U1 A0A075B5U1_MOUSE ENSMUST00000103501.1 ENSMUST00000103501.2 Ighv1-16 uc288jya.1 uc288jya.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jya.1 uc288jya.2 
ENSMUST00000103503.4 Ighv1-62-1 ENSMUST00000103503.4 Ighv1-62-1 (from geneSymbol) A0A075B5U3 A0A075B5U3_MOUSE BC018315 ENSMUST00000103503.1 ENSMUST00000103503.2 ENSMUST00000103503.3 Ighv1-62-1 uc288kay.1 uc288kay.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kay.1 uc288kay.2 
ENSMUST00000103507.2 Ighv1-22 ENSMUST00000103507.2 Ighv1-22 (from geneSymbol) A0A075B5U7 A0A075B5U7_MOUSE BC033451 ENSMUST00000103507.1 Ighv1-22 uc288jym.1 uc288jym.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jym.1 uc288jym.2 
ENSMUST00000103510.2 Ighv1-26 ENSMUST00000103510.2 Ighv1-26 (from geneSymbol) A0A075B5V0 A0A075B5V0_MOUSE ENSMUST00000103510.1 Ighv1-26 U88682 uc288jyr.1 uc288jyr.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jyr.1 uc288jyr.2 
ENSMUST00000103512.3 Ighv1-34 ENSMUST00000103512.3 Ighv1-34 (from geneSymbol) A0A075B5V2 A0A075B5V2_MOUSE E07912 ENSMUST00000103512.1 ENSMUST00000103512.2 Ighv1-34 uc288jza.1 uc288jza.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jza.1 uc288jza.2 
ENSMUST00000103515.2 Ighv1-39 ENSMUST00000103515.2 Ighv1-39 (from geneSymbol) A0A075B5V5 A0A075B5V5_MOUSE AJ277813 ENSMUST00000103515.1 Ighv1-39 uc288jzh.1 uc288jzh.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jzh.1 uc288jzh.2 
ENSMUST00000103521.3 Ighv1-50 ENSMUST00000103521.3 Ighv1-50 (from geneSymbol) A0A075B5W1 A0A075B5W1_MOUSE ENSMUST00000103521.1 ENSMUST00000103521.2 Ighv1-50 LC050825 uc288kaa.1 uc288kaa.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kaa.1 uc288kaa.2 
ENSMUST00000103523.2 Ighv1-53 ENSMUST00000103523.2 Ighv1-53 (from geneSymbol) A0A075B5W3 A0A075B5W3_MOUSE AF045484 ENSMUST00000103523.1 Ighv1-53 uc288kae.1 uc288kae.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kae.1 uc288kae.2 
ENSMUST00000103525.3 Ighv1-54 ENSMUST00000103525.3 Ighv1-54 (from geneSymbol) A0A075B5W5 A0A075B5W5_MOUSE ENSMUST00000103525.1 ENSMUST00000103525.2 Ighv1-54 M15047 uc288kai.1 uc288kai.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kai.1 uc288kai.2 
ENSMUST00000103526.3 Ighv1-55 ENSMUST00000103526.3 Ighv1-55 (from geneSymbol) A0A075B5W6 A0A075B5W6_MOUSE ENSMUST00000103526.1 ENSMUST00000103526.2 Ighv1-55 X12412 uc288kaj.1 uc288kaj.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kaj.1 uc288kaj.2 
ENSMUST00000103529.4 Ighv1-58 ENSMUST00000103529.4 Ighv1-58 (from geneSymbol) A0A075B5W9 A0A075B5W9_MOUSE ENSMUST00000103529.1 ENSMUST00000103529.2 ENSMUST00000103529.3 Ighv1-58 LC387253 uc288kas.1 uc288kas.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kas.1 uc288kas.2 
ENSMUST00000103531.4 Ighv1-61 ENSMUST00000103531.4 This germline gene belongs to a set of closely related genes that could encode V regions of NPb antibodies. (from UniProt P01749) AY648598 ENSMUST00000103531.1 ENSMUST00000103531.2 ENSMUST00000103531.3 HVM05_MOUSE Igh-VJ558 P01749 uc288kaw.1 uc288kaw.2 This germline gene belongs to a set of closely related genes that could encode V regions of NPb antibodies. adaptive immune response immune system process antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin complex immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kaw.1 uc288kaw.2 
ENSMUST00000103532.3 Ighv1-62-3 ENSMUST00000103532.3 This germline gene belongs to a set of closely related genes that could encode V regions of NPb antibodies. (from UniProt P01754) AJ012555 ENSMUST00000103532.1 ENSMUST00000103532.2 HVM10_MOUSE Igh-VJ558 P01754 P11270 uc288kbf.1 uc288kbf.2 This germline gene belongs to a set of closely related genes that could encode V regions of NPb antibodies. adaptive immune response immune system process antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin complex immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kbf.1 uc288kbf.2 
ENSMUST00000103534.2 Ighv1-63 ENSMUST00000103534.2 Ighv1-63 (from geneSymbol) A0A075B5X2 A0A075B5X2_MOUSE ENSMUST00000103534.1 Ighv1-63 M33856 uc288kbj.1 uc288kbj.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kbj.1 uc288kbj.2 
ENSMUST00000103535.3 Ighv1-64 ENSMUST00000103535.3 Ighv1-64 (from geneSymbol) A0A075B5X3 A0A075B5X3_MOUSE AF045487 ENSMUST00000103535.1 ENSMUST00000103535.2 Ighv1-64 uc288kbl.1 uc288kbl.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kbl.1 uc288kbl.2 
ENSMUST00000103536.4 Ighv8-11 ENSMUST00000103536.4 Ighv8-11 (from geneSymbol) A0A075B5X4 A0A075B5X4_MOUSE ENSMUST00000103536.1 ENSMUST00000103536.2 ENSMUST00000103536.3 Ighv8-11 L22744 uc288kbq.1 uc288kbq.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kbq.1 uc288kbq.2 
ENSMUST00000103537.3 Ighv1-66 ENSMUST00000103537.3 Ighv1-66 (from geneSymbol) A0A075B5X5 A0A075B5X5_MOUSE BC094065 ENSMUST00000103537.1 ENSMUST00000103537.2 Ighv1-66 uc288kbs.1 uc288kbs.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kbs.1 uc288kbs.2 
ENSMUST00000103541.3 Ighv1-72 ENSMUST00000103541.3 Ighv1-72 (from geneSymbol) A0A075B5X9 ENSMUST00000103541.1 ENSMUST00000103541.2 HVM49_MOUSE Ighv1-72 M27788 P06328 uc288kch.1 uc288kch.2 adaptive immune response immune system process antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin complex immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kch.1 uc288kch.2 
ENSMUST00000103542.2 Ighv8-13 ENSMUST00000103542.2 Ighv8-13 (from geneSymbol) A0A075B5Y0 A0A075B5Y0_MOUSE E07584 ENSMUST00000103542.1 Ighv8-13 uc288kci.1 uc288kci.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kci.1 uc288kci.2 
ENSMUST00000103544.3 Ighv1-75 ENSMUST00000103544.3 Ighv1-75 (from geneSymbol) A0A075B5Y2 A0A075B5Y2_MOUSE ENSMUST00000103544.1 ENSMUST00000103544.2 Ighv1-75 uc288kcr.1 uc288kcr.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kcr.1 uc288kcr.2 
ENSMUST00000103547.2 Ighv1-80 ENSMUST00000103547.2 Ighv1-80 (from geneSymbol) A0A075B5Y3 A0A075B5Y3_MOUSE ENSMUST00000103547.1 Ighv1-80 LC110288 uc288kde.1 uc288kde.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kde.1 uc288kde.2 
ENSMUST00000103548.3 Ighv1-81 ENSMUST00000103548.3 Ighv1-81 (from geneSymbol) A0A075B5Y4 A0A075B5Y4_MOUSE ENSMUST00000103548.1 ENSMUST00000103548.2 Ighv1-81 LC110288 uc288kdf.1 uc288kdf.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kdf.1 uc288kdf.2 
ENSMUST00000103551.2 Ighv1-84 ENSMUST00000103551.2 Ighv1-84 (from geneSymbol) A0A075B5Y5 A0A075B5Y5_MOUSE AF045503 ENSMUST00000103551.1 Ighv1-84 uc288kdl.1 uc288kdl.2 uc288kdl.1 uc288kdl.2 
ENSMUST00000103552.2 Ighv1-85 ENSMUST00000103552.2 Ighv1-85 (from geneSymbol) A0A075B5Y6 A0A075B5Y6_MOUSE ENSMUST00000103552.1 Ighv1-85 uc288kdn.1 uc288kdn.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kdn.1 uc288kdn.2 
ENSMUST00000103553.3 Trgv7 ENSMUST00000103553.3 Trgv7 (from geneSymbol) A0A0A6YYE8 A0A0A6YYE8_MOUSE ENSMUST00000103553.1 ENSMUST00000103553.2 M71214 Tcrg-V7 Trgv7 uc007poq.1 uc007poq.2 uc007poq.3 external side of plasma membrane uc007poq.1 uc007poq.2 uc007poq.3 
ENSMUST00000103554.5 Trgv4 ENSMUST00000103554.5 Trgv4 (from geneSymbol) A0A0B4J1J8 A0A0B4J1J8_MOUSE ENSMUST00000103554.1 ENSMUST00000103554.2 ENSMUST00000103554.3 ENSMUST00000103554.4 Tcrg-V4 Trgv4 X04699 uc288lbm.1 uc288lbm.2 external side of plasma membrane uc288lbm.1 uc288lbm.2 
ENSMUST00000103558.3 Trgc1 ENSMUST00000103558.3 Trgc1 (from geneSymbol) A0A075B5Z0 A0A075B5Z0_MOUSE ENSMUST00000103558.1 ENSMUST00000103558.2 M30174 Tcrg-C1 Trgc1 uc288lbs.1 uc288lbs.2 membrane integral component of membrane homeostasis of number of cells within a tissue uc288lbs.1 uc288lbs.2 
ENSMUST00000103561.3 Trgc2 ENSMUST00000103561.3 Trgc2 (from geneSymbol) A0A075B5Z2 A0A075B5Z2_MOUSE BC054086 ENSMUST00000103561.1 ENSMUST00000103561.2 Tcrg-C2 Trgc2 uc288lby.1 uc288lby.2 membrane integral component of membrane uc288lby.1 uc288lby.2 
ENSMUST00000103562.3 Trgj3 ENSMUST00000103562.3 Trgj3 (from geneSymbol) A0A0G2JEI4 A0A0G2JEI4_MOUSE ENSMUST00000103562.1 ENSMUST00000103562.2 Trgj3 uc288lbv.1 uc288lbv.2 uc288lbv.1 uc288lbv.2 
ENSMUST00000103563.3 Trgv2 ENSMUST00000103563.3 Trgv2 (from geneSymbol) A2J008 A2J008_MOUSE ENSMUST00000103563.1 ENSMUST00000103563.2 Trgv2 X04397 uc007pow.1 uc007pow.2 uc007pow.3 external side of plasma membrane uc007pow.1 uc007pow.2 uc007pow.3 
ENSMUST00000103564.3 Trgv1 ENSMUST00000103564.3 Trgv1 (from geneSymbol) AK088363 ENSMUST00000103564.1 ENSMUST00000103564.2 Gm16602 P03978 TVC2_MOUSE Tcrg-V1 uc288lca.1 uc288lca.2 adaptive immune response immune system process external side of plasma membrane T cell receptor complex uc288lca.1 uc288lca.2 
ENSMUST00000103567.6 Trav1 ENSMUST00000103567.6 Trav1 (from geneSymbol) A0A075B5Z4 A0A075B5Z4_MOUSE ENSMUST00000103567.1 ENSMUST00000103567.2 ENSMUST00000103567.3 ENSMUST00000103567.4 ENSMUST00000103567.5 Trav1 uc007tpk.1 uc007tpk.2 uc007tpk.3 uc007tpk.1 uc007tpk.2 uc007tpk.3 
ENSMUST00000103569.3 Trav3-1 ENSMUST00000103569.3 Trav3-1 (from geneSymbol) AJ311366 ENSMUST00000103569.1 ENSMUST00000103569.2 Q5R1I8 Q5R1I8_MOUSE TRAV3-1 Trav3-1 uc288twc.1 uc288twc.2 molecular_function cellular_component biological_process uc288twc.1 uc288twc.2 
ENSMUST00000103570.2 Trav5-1 ENSMUST00000103570.2 Trav5-1 (from geneSymbol) A0A075B5Z7 A0A075B5Z7_MOUSE ENSMUST00000103570.1 Trav5-1 uc288twe.1 uc288twe.2 uc288twe.1 uc288twe.2 
ENSMUST00000103571.2 Trav6-1 ENSMUST00000103571.2 Trav6-1 (from geneSymbol) A0A075B5Z8 A0A075B5Z8_MOUSE ENSMUST00000103571.1 Trav6-1 X14387 uc288twf.1 uc288twf.2 immunoglobulin production extracellular space immune response uc288twf.1 uc288twf.2 
ENSMUST00000103580.4 Trav8d-1 ENSMUST00000103580.4 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt Q5R1H8) ENSMUST00000103580.1 ENSMUST00000103580.2 ENSMUST00000103580.3 Q5R1H8 Q5R1H8_MOUSE TRAV8D-1 Trav8d-1 uc288tws.1 uc288tws.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. Membrane uc288tws.1 uc288tws.2 
ENSMUST00000103581.6 Trav9-1 ENSMUST00000103581.6 Trav9-1 (from geneSymbol) A0A075B601 A0A075B601_MOUSE ENSMUST00000103581.1 ENSMUST00000103581.2 ENSMUST00000103581.3 ENSMUST00000103581.4 ENSMUST00000103581.5 M76612 Trav9-1 uc288uad.1 uc288uad.2 uc288uad.1 uc288uad.2 
ENSMUST00000103583.5 Trav10 ENSMUST00000103583.5 Trav10 (from geneSymbol) A0A075B602 A0A075B642 A0A075B642_MOUSE ENSMUST00000103583.1 ENSMUST00000103583.2 ENSMUST00000103583.3 ENSMUST00000103583.4 L34678 Trav10 Trav10d uc007tsh.1 uc007tsh.2 uc007tsh.3 uc007tsh.4 uc007tsh.1 uc007tsh.2 uc007tsh.3 uc007tsh.4 
ENSMUST00000103584.4 Trav6-6 ENSMUST00000103584.4 Trav6-6 (from geneSymbol) A0A075B603 A0A075B603_MOUSE ENSMUST00000103584.1 ENSMUST00000103584.2 ENSMUST00000103584.3 FJ188405 Trav6-6 Trav6d-6 uc288uaf.1 uc288uaf.2 immunoglobulin production extracellular space immune response uc288uaf.1 uc288uaf.2 
ENSMUST00000103585.4 Trav11 ENSMUST00000103585.4 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A0B4J1J9) A0A0B4J1J9 A0A0B4J1J9_MOUSE DQ340292 ENSMUST00000103585.1 ENSMUST00000103585.2 ENSMUST00000103585.3 Trav11 Trav11d uc057bez.1 uc057bez.2 uc057bez.3 uc057bez.4 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc057bez.1 uc057bez.2 uc057bez.3 uc057bez.4 
ENSMUST00000103588.4 Trav13d-1 ENSMUST00000103588.4 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A075B606) A0A075B606 A0A075B606_MOUSE ENSMUST00000103588.1 ENSMUST00000103588.2 ENSMUST00000103588.3 Trav13d-1 uc007tqc.1 uc007tqc.2 uc007tqc.3 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc007tqc.1 uc007tqc.2 uc007tqc.3 
ENSMUST00000103589.6 Trav14-3 ENSMUST00000103589.6 Trav14-3 (from geneSymbol) A0A075B607 A0A075B607_MOUSE ENSMUST00000103589.1 ENSMUST00000103589.2 ENSMUST00000103589.3 ENSMUST00000103589.4 ENSMUST00000103589.5 Trav14-3 U07875 uc029ske.1 uc029ske.2 uc029ske.3 uc029ske.4 uc029ske.1 uc029ske.2 uc029ske.3 uc029ske.4 
ENSMUST00000103592.2 Trav4d-3 ENSMUST00000103592.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A075B625) A0A075B625 A0A075B625_MOUSE AF479022 ENSMUST00000103592.1 Trav4d-3 Trav4n-3 uc007tqh.1 uc007tqh.2 uc007tqh.3 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. Membrane uc007tqh.1 uc007tqh.2 uc007tqh.3 
ENSMUST00000103600.3 Trav4d-4 ENSMUST00000103600.3 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A075B615) A0A075B615 A0A075B615_MOUSE ENSMUST00000103600.1 ENSMUST00000103600.2 Trav4d-4 Trav4n-4 X03860 uc029sjh.1 uc029sjh.2 uc029sjh.3 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc029sjh.1 uc029sjh.2 uc029sjh.3 
ENSMUST00000103606.2 Trav16d-dv11 ENSMUST00000103606.2 Trav16d-dv11 (from geneSymbol) A0A075B617 A0A075B617_MOUSE AK088475 ENSMUST00000103606.1 Trav16d-dv11 uc007tqt.1 uc007tqt.2 uc007tqt.3 immunoglobulin production extracellular space immune response uc007tqt.1 uc007tqt.2 uc007tqt.3 
ENSMUST00000103608.4 Trav14d-3-dv8 ENSMUST00000103608.4 Trav14d-3-dv8 (from geneSymbol) A0A075B619 A0A075B619_MOUSE BC147846 ENSMUST00000103608.1 ENSMUST00000103608.2 ENSMUST00000103608.3 Trav14d-3-dv8 uc288tyh.1 uc288tyh.2 uc288tyh.1 uc288tyh.2 
ENSMUST00000103609.2 Trav7n-4 ENSMUST00000103609.2 Trav7n-4 (from geneSymbol) A0A075B620 A0A075B620_MOUSE ENSMUST00000103609.1 Trav7n-4 X56722 uc288tyj.1 uc288tyj.2 uc288tyj.1 uc288tyj.2 
ENSMUST00000103611.2 Trav6n-5 ENSMUST00000103611.2 Trav6n-5 (from geneSymbol) A0A075B621 A0A075B621_MOUSE ENSMUST00000103611.1 Trav6n-5 uc288tyk.1 uc288tyk.2 immunoglobulin production extracellular space immune response uc288tyk.1 uc288tyk.2 
ENSMUST00000103612.2 Trav10n ENSMUST00000103612.2 Trav10n (from geneSymbol) A0A075B622 A0A075B622_MOUSE ENSMUST00000103612.1 Trav10n U07654 uc288tyl.1 uc288tyl.2 uc288tyl.1 uc288tyl.2 
ENSMUST00000103616.5 Trav15d-1-dv6d-1 ENSMUST00000103616.5 Trav15d-1-dv6d-1 (from geneSymbol) A0A075B624 A0A075B624_MOUSE ENSMUST00000103616.1 ENSMUST00000103616.2 ENSMUST00000103616.3 ENSMUST00000103616.4 Trav15d-1-dv6d-1 X02935 uc007tqe.1 uc007tqe.2 uc007tqe.3 immunoglobulin production extracellular space immune response uc007tqe.1 uc007tqe.2 uc007tqe.3 
ENSMUST00000103618.2 Trav4n-3 ENSMUST00000103618.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A075B625) A0A075B625 A0A075B625_MOUSE ENSMUST00000103618.1 Trav4d-3 Trav4n-3 uc007trd.1 uc007trd.2 uc007trd.3 uc007trd.4 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. Membrane uc007trd.1 uc007trd.2 uc007trd.3 uc007trd.4 
ENSMUST00000103626.3 Trav9n-4 ENSMUST00000103626.3 Trav9n-4 (from geneSymbol) A0A075B631 A0A075B631_MOUSE AK138453 ENSMUST00000103626.1 ENSMUST00000103626.2 Trav9n-4 uc288tzo.1 uc288tzo.2 uc288tzo.1 uc288tzo.2 
ENSMUST00000103627.3 Trav4n-4 ENSMUST00000103627.3 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A075B615) A0A075B615 A0A075B615_MOUSE ENSMUST00000103627.1 ENSMUST00000103627.2 Trav4d-4 Trav4n-4 X03860 uc029sjp.1 uc029sjp.2 uc029sjp.3 uc029sjp.4 uc029sjp.5 uc029sjp.6 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc029sjp.1 uc029sjp.2 uc029sjp.3 uc029sjp.4 uc029sjp.5 uc029sjp.6 
ENSMUST00000103632.4 Trav8n-2 ENSMUST00000103632.4 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A075B633) A0A075B633 A0A075B633_MOUSE ENSMUST00000103632.1 ENSMUST00000103632.2 ENSMUST00000103632.3 S64065 Trav8n-2 uc007trv.1 uc007trv.2 uc007trv.3 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. Membrane uc007trv.1 uc007trv.2 uc007trv.3 
ENSMUST00000103633.2 Trav16n ENSMUST00000103633.2 Trav16n (from geneSymbol) A0A075B634 A0A075B634_MOUSE AF296661 ENSMUST00000103633.1 Trav16n uc288tzs.1 uc288tzs.2 immunoglobulin production extracellular space immune response uc288tzs.1 uc288tzs.2 
ENSMUST00000103636.4 Trav7-2 ENSMUST00000103636.4 Trav7-2 (from geneSymbol) ENSMUST00000103636.1 ENSMUST00000103636.2 ENSMUST00000103636.3 Q5R1I3 Q5R1I3_MOUSE TRAV7D-2 Trav7-2 Trav7d-2 uc288tzy.1 uc288tzy.2 molecular_function cellular_component biological_process uc288tzy.1 uc288tzy.2 
ENSMUST00000103637.6 Trav4-2 ENSMUST00000103637.6 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A075B638) A0A075B638 A0A075B638_MOUSE ENSMUST00000103637.1 ENSMUST00000103637.2 ENSMUST00000103637.3 ENSMUST00000103637.4 ENSMUST00000103637.5 M87848 Trav4-2 uc288tzz.1 uc288tzz.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc288tzz.1 uc288tzz.2 
ENSMUST00000103638.6 Trav6-7-dv9 ENSMUST00000103638.6 Trav6-7-dv9 (from geneSymbol) A0A075B639 A0A075B639_MOUSE AK154054 ENSMUST00000103638.1 ENSMUST00000103638.2 ENSMUST00000103638.3 ENSMUST00000103638.4 ENSMUST00000103638.5 Trav6-7-dv9 uc007ttg.1 uc007ttg.2 uc007ttg.3 uc007ttg.4 immunoglobulin production extracellular space immune response uc007ttg.1 uc007ttg.2 uc007ttg.3 uc007ttg.4 
ENSMUST00000103641.6 Trav7-6 ENSMUST00000103641.6 Trav7-6 (from geneSymbol) A0A075B640 A0A075B640_MOUSE ENSMUST00000103641.1 ENSMUST00000103641.2 ENSMUST00000103641.3 ENSMUST00000103641.4 ENSMUST00000103641.5 Trav7-6 X63927 uc007tth.1 uc007tth.2 uc007tth.3 uc007tth.1 uc007tth.2 uc007tth.3 
ENSMUST00000103643.4 Trav8-1 ENSMUST00000103643.4 Trav8-1 (from geneSymbol) A0A075B641 A0A075B641_MOUSE ENSMUST00000103643.1 ENSMUST00000103643.2 ENSMUST00000103643.3 KY964547 Trav8-1 uc057ksk.1 uc057ksk.2 uc057ksk.3 uc057ksk.1 uc057ksk.2 uc057ksk.3 
ENSMUST00000103646.5 Trav10d ENSMUST00000103646.5 Trav10d (from geneSymbol) A0A075B602 A0A075B642 A0A075B642_MOUSE ENSMUST00000103646.1 ENSMUST00000103646.2 ENSMUST00000103646.3 ENSMUST00000103646.4 Trav10 Trav10d U47051 uc007tpy.1 uc007tpy.2 uc007tpy.3 uc007tpy.1 uc007tpy.2 uc007tpy.3 
ENSMUST00000103648.4 Trav11d ENSMUST00000103648.4 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A0B4J1J9) A0A0B4J1J9 A0A0B4J1J9_MOUSE ENSMUST00000103648.1 ENSMUST00000103648.2 ENSMUST00000103648.3 Trav11 Trav11d uc288twv.1 uc288twv.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc288twv.1 uc288twv.2 
ENSMUST00000103651.4 Trav13-1 ENSMUST00000103651.4 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A075B644) A0A075B644 A0A075B644_MOUSE ENSMUST00000103651.1 ENSMUST00000103651.2 ENSMUST00000103651.3 M20875 Trav13-1 uc011zkx.1 uc011zkx.2 uc011zkx.3 uc011zkx.4 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc011zkx.1 uc011zkx.2 uc011zkx.3 uc011zkx.4 
ENSMUST00000103652.5 Trav14n-3 ENSMUST00000103652.5 Trav14n-3 (from geneSymbol) A0A075B645 A0A075B645_MOUSE ENSMUST00000103652.1 ENSMUST00000103652.2 ENSMUST00000103652.3 ENSMUST00000103652.4 Trav14-1 Trav14n-3 U07878 uc288tzv.1 uc288tzv.2 uc288tzv.1 uc288tzv.2 
ENSMUST00000103654.3 Trav9-2 ENSMUST00000103654.3 Trav9-2 (from geneSymbol) A0A075B647 A0A075B647_MOUSE BC099394 ENSMUST00000103654.1 ENSMUST00000103654.2 Trav9-2 uc288uan.1 uc288uan.2 uc288uan.1 uc288uan.2 
ENSMUST00000103655.3 Trav4-3 ENSMUST00000103655.3 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A0B4J1K1) A0A0B4J1K1 A0A0B4J1K1_MOUSE AK137936 ENSMUST00000103655.1 ENSMUST00000103655.2 Trav4-3 uc029skc.1 uc029skc.2 uc029skc.3 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. Membrane uc029skc.1 uc029skc.2 uc029skc.3 
ENSMUST00000103657.6 Trav12-3 ENSMUST00000103657.6 Trav12-3 (from geneSymbol) A0A075B648 A0A075B648_MOUSE DQ186679 ENSMUST00000103657.1 ENSMUST00000103657.2 ENSMUST00000103657.3 ENSMUST00000103657.4 ENSMUST00000103657.5 Trav12-3 uc007tsu.1 uc007tsu.2 uc007tsu.3 uc007tsu.4 immunoglobulin production extracellular space immune response uc007tsu.1 uc007tsu.2 uc007tsu.3 uc007tsu.4 
ENSMUST00000103658.4 Trav13-2 ENSMUST00000103658.4 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A075B649) A0A075B649 A0A075B649_MOUSE ENSMUST00000103658.1 ENSMUST00000103658.2 ENSMUST00000103658.3 Trav13-2 U07874 uc007tsw.1 uc007tsw.2 uc007tsw.3 uc007tsw.4 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc007tsw.1 uc007tsw.2 uc007tsw.3 uc007tsw.4 
ENSMUST00000103660.4 Trav15-2-dv6-2 ENSMUST00000103660.4 Trav15-2-dv6-2 (from geneSymbol) A0A075B650 A0A075B650_MOUSE ENSMUST00000103660.1 ENSMUST00000103660.2 ENSMUST00000103660.3 M37286 Trav15-2-dv6-2 uc007ttb.1 uc007ttb.2 uc007ttb.3 immunoglobulin production extracellular space immune response uc007ttb.1 uc007ttb.2 uc007ttb.3 
ENSMUST00000103662.6 Trav9-4 ENSMUST00000103662.6 Trav9-4 (from geneSymbol) A0A0B4J1K2 A0A0B4J1K2_MOUSE E01014 ENSMUST00000103662.1 ENSMUST00000103662.2 ENSMUST00000103662.3 ENSMUST00000103662.4 ENSMUST00000103662.5 Trav9-4 uc057kso.1 uc057kso.2 uc057kso.3 uc057kso.1 uc057kso.2 uc057kso.3 
ENSMUST00000103663.6 Trav4-4-dv10 ENSMUST00000103663.6 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A075B651) A0A075B651 A0A075B651_MOUSE ENSMUST00000103663.1 ENSMUST00000103663.2 ENSMUST00000103663.3 ENSMUST00000103663.4 ENSMUST00000103663.5 Trav4-4-dv10 X02968 uc011zla.1 uc011zla.2 uc011zla.3 uc011zla.4 uc011zla.5 uc011zla.6 uc011zla.7 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc011zla.1 uc011zla.2 uc011zla.3 uc011zla.4 uc011zla.5 uc011zla.6 uc011zla.7 
ENSMUST00000103664.6 Trav5-4 ENSMUST00000103664.6 Trav5-4 (from geneSymbol) A0A075B652 A0A075B652_MOUSE ENSMUST00000103664.1 ENSMUST00000103664.2 ENSMUST00000103664.3 ENSMUST00000103664.4 ENSMUST00000103664.5 Trav5-4 U07877 uc007ttf.1 uc007ttf.2 uc007ttf.3 uc007ttf.4 uc007ttf.5 uc007ttf.6 uc007ttf.7 uc007ttf.1 uc007ttf.2 uc007ttf.3 uc007ttf.4 uc007ttf.5 uc007ttf.6 uc007ttf.7 
ENSMUST00000103667.6 Trav16 ENSMUST00000103667.6 Trav16 (from geneSymbol) A0A075B653 A0A075B653_MOUSE ENSMUST00000103667.1 ENSMUST00000103667.2 ENSMUST00000103667.3 ENSMUST00000103667.4 ENSMUST00000103667.5 M16119 Trav16 uc288uax.1 uc288uax.2 immunoglobulin production extracellular space immune response uc288uax.1 uc288uax.2 
ENSMUST00000103670.4 Trav3-4 ENSMUST00000103670.4 Trav3-4 (from geneSymbol) A0A075B654 A0A075B654_MOUSE AK043253 ENSMUST00000103670.1 ENSMUST00000103670.2 ENSMUST00000103670.3 Trav3-4 uc288uba.1 uc288uba.2 uc288uba.1 uc288uba.2 
ENSMUST00000103671.4 Trav13-5 ENSMUST00000103671.4 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A0B4J1K3) A0A0B4J1K3 A0A0B4J1K3_MOUSE AK046242 B230359F08Rik ENSMUST00000103671.1 ENSMUST00000103671.2 ENSMUST00000103671.3 Trav13-5 uc288ubc.1 uc288ubc.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. molecular_function cellular_component biological_process uc288ubc.1 uc288ubc.2 
ENSMUST00000103672.9 Trav17 ENSMUST00000103672.9 Trav17 (from geneSymbol) A0A075B655 A0A075B655_MOUSE ENSMUST00000103672.1 ENSMUST00000103672.2 ENSMUST00000103672.3 ENSMUST00000103672.4 ENSMUST00000103672.5 ENSMUST00000103672.6 ENSMUST00000103672.7 ENSMUST00000103672.8 Trav17 U07883 uc288ubd.1 uc288ubd.2 uc288ubd.1 uc288ubd.2 
ENSMUST00000103673.11 Trav18 ENSMUST00000103673.11 Trav18 (from geneSymbol) A0A075B656 A0A075B656_MOUSE ENSMUST00000103673.1 ENSMUST00000103673.10 ENSMUST00000103673.2 ENSMUST00000103673.3 ENSMUST00000103673.4 ENSMUST00000103673.5 ENSMUST00000103673.6 ENSMUST00000103673.7 ENSMUST00000103673.8 ENSMUST00000103673.9 Trav18 uc033gqp.1 uc033gqp.2 uc033gqp.3 uc033gqp.1 uc033gqp.2 uc033gqp.3 
ENSMUST00000103674.6 Trav19 ENSMUST00000103674.6 Trav19 (from geneSymbol) A0A0B4J1K4 A0A0B4J1K4_MOUSE ENSMUST00000103674.1 ENSMUST00000103674.2 ENSMUST00000103674.3 ENSMUST00000103674.4 ENSMUST00000103674.5 Trav19 X72904 uc288ubg.1 uc288ubg.2 uc288ubg.1 uc288ubg.2 
ENSMUST00000103676.9 Trdv1 ENSMUST00000103676.9 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A075B657) A0A075B657 A0A075B657_MOUSE ENSMUST00000103676.1 ENSMUST00000103676.2 ENSMUST00000103676.3 ENSMUST00000103676.4 ENSMUST00000103676.5 ENSMUST00000103676.6 ENSMUST00000103676.7 ENSMUST00000103676.8 Trdv1 uc288ubj.1 uc288ubj.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. Membrane uc288ubj.1 uc288ubj.2 
ENSMUST00000103678.4 Trdv2-2 ENSMUST00000103678.4 Trdv2-2 (from geneSymbol) A0A075B659 AK042507 ENSMUST00000103678.1 ENSMUST00000103678.2 ENSMUST00000103678.3 Q5R1A4 Q5R1A4_MOUSE TRDV2-2 Trdv2-2 uc007ttt.1 uc007ttt.2 immunoglobulin production extracellular space immune response uc007ttt.1 uc007ttt.2 
ENSMUST00000103679.3 Trdv4 ENSMUST00000103679.3 Trdv4 (from geneSymbol) AK041790 ENSMUST00000103679.1 ENSMUST00000103679.2 Q5R1A3 Q5R1A3_MOUSE TRDV4 Trdv4 uc288ubs.1 uc288ubs.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288ubs.1 uc288ubs.2 
ENSMUST00000103682.3 Trdj1 ENSMUST00000103682.3 Trdj1 (from geneSymbol) A0A0G2JG53 A0A0G2JG53_MOUSE ENSMUST00000103682.1 ENSMUST00000103682.2 Trdj1 uc288uby.1 uc288uby.2 uc288uby.1 uc288uby.2 
ENSMUST00000103683.2 Trdj2 ENSMUST00000103683.2 Trdj2 (from geneSymbol) A0A0G2JFW2 A0A0G2JFW2_MOUSE ENSMUST00000103683.1 Trdj2 uc288uca.1 uc288uca.2 uc288uca.1 uc288uca.2 
ENSMUST00000103685.3 Trdv5 ENSMUST00000103685.3 Trdv5 (from geneSymbol) A0A075B661 A0A075B661_MOUSE ENSMUST00000103685.1 ENSMUST00000103685.2 M23096 Trdv5 uc007ttz.1 uc007ttz.2 immunoglobulin production extracellular space immune response uc007ttz.1 uc007ttz.2 
ENSMUST00000103687.2 Traj58 ENSMUST00000103687.2 Traj58 (from geneSymbol) A0A0G2JFA3 A0A0G2JFA3_MOUSE ENSMUST00000103687.1 Traj58 uc288ucg.1 uc288ucg.2 uc288ucg.1 uc288ucg.2 
ENSMUST00000103689.2 Traj56 ENSMUST00000103689.2 Traj56 (from geneSymbol) A0A0G2JDZ0 A0A0G2JDZ0_MOUSE ENSMUST00000103689.1 Traj56 U89738 uc007tud.1 uc007tud.2 uc007tud.3 uc007tud.1 uc007tud.2 uc007tud.3 
ENSMUST00000103690.2 Traj53 ENSMUST00000103690.2 Traj53 (from geneSymbol) A0A0G2JGM9 A0A0G2JGM9_MOUSE ENSMUST00000103690.1 M38675 Traj53 uc288ucl.1 uc288ucl.2 uc288ucl.1 uc288ucl.2 
ENSMUST00000103691.2 Traj52 ENSMUST00000103691.2 Traj52 (from geneSymbol) A0A0G2JFS6 A0A0G2JFS6_MOUSE ENSMUST00000103691.1 Traj52 U86715 uc288ucm.1 uc288ucm.2 molecular_function cellular_component biological_process uc288ucm.1 uc288ucm.2 
ENSMUST00000103693.2 Traj50 ENSMUST00000103693.2 Traj50 (from geneSymbol) A0A0G2JEE5 A0A0G2JEE5_MOUSE ENSMUST00000103693.1 Traj50 uc288ucn.1 uc288ucn.2 uc288ucn.1 uc288ucn.2 
ENSMUST00000103696.2 Traj46 ENSMUST00000103696.2 Traj46 (from geneSymbol) A0A0G2JGR3 A0A0G2JGR3_MOUSE ENSMUST00000103696.1 Traj46 uc288uct.1 uc288uct.2 uc288uct.1 uc288uct.2 
ENSMUST00000103697.2 Traj45 ENSMUST00000103697.2 Traj45 (from geneSymbol) A0A0G2JFC4 A0A0G2JFC4_MOUSE ENSMUST00000103697.1 Traj45 U86717 uc288ucu.1 uc288ucu.2 uc288ucu.1 uc288ucu.2 
ENSMUST00000103698.2 Traj44 ENSMUST00000103698.2 Traj44 (from geneSymbol) A0A0G2JE22 A0A0G2JE22_MOUSE ENSMUST00000103698.1 Traj44 uc288ucv.1 uc288ucv.2 uc288ucv.1 uc288ucv.2 
ENSMUST00000103699.2 Traj43 ENSMUST00000103699.2 Traj43 (from geneSymbol) A0A0G2JE21 A0A0G2JE21_MOUSE AK030929 ENSMUST00000103699.1 Traj43 uc288ucw.1 uc288ucw.2 uc288ucw.1 uc288ucw.2 
ENSMUST00000103700.2 Traj42 ENSMUST00000103700.2 Traj42 (from geneSymbol) A0A0G2JFN0 A0A0G2JFN0_MOUSE AK030929 ENSMUST00000103700.1 Traj42 uc288ucx.1 uc288ucx.2 uc288ucx.1 uc288ucx.2 
ENSMUST00000103701.2 Traj41 ENSMUST00000103701.2 Traj41 (from geneSymbol) A0A0G2JF06 A0A0G2JF06_MOUSE AK030929 ENSMUST00000103701.1 Traj41 uc288ucy.1 uc288ucy.2 uc288ucy.1 uc288ucy.2 
ENSMUST00000103702.2 Traj40 ENSMUST00000103702.2 Traj40 (from geneSymbol) A0A0G2JH15 A0A0G2JH15_MOUSE ENSMUST00000103702.1 Traj40 uc288ucz.1 uc288ucz.2 uc288ucz.1 uc288ucz.2 
ENSMUST00000103703.2 Traj39 ENSMUST00000103703.2 Traj39 (from geneSymbol) A0A0G2JDX5 A0A0G2JDX5_MOUSE ENSMUST00000103703.1 Traj39 uc288uda.1 uc288uda.2 uc288uda.1 uc288uda.2 
ENSMUST00000103704.2 Traj38 ENSMUST00000103704.2 Traj38 (from geneSymbol) A0A0G2JFM0 A0A0G2JFM0_MOUSE ENSMUST00000103704.1 Traj38 uc288udb.1 uc288udb.2 uc288udb.1 uc288udb.2 
ENSMUST00000103705.2 Traj37 ENSMUST00000103705.2 Traj37 (from geneSymbol) A0A0G2JGK9 A0A0G2JGK9_MOUSE ENSMUST00000103705.1 Traj37 uc288udc.1 uc288udc.2 uc288udc.1 uc288udc.2 
ENSMUST00000103706.2 Traj35 ENSMUST00000103706.2 Traj35 (from geneSymbol) A0A0G2JFU1 A0A0G2JFU1_MOUSE ENSMUST00000103706.1 Traj35 uc288ude.1 uc288ude.2 uc288ude.1 uc288ude.2 
ENSMUST00000103707.2 Traj34 ENSMUST00000103707.2 Traj34 (from geneSymbol) A0A0G2JGM3 A0A0G2JGM3_MOUSE ENSMUST00000103707.1 M37595 Traj34 uc288udf.1 uc288udf.2 uc288udf.1 uc288udf.2 
ENSMUST00000103708.2 Traj33 ENSMUST00000103708.2 Traj33 (from geneSymbol) A0A0G2JDY8 A0A0G2JDY8_MOUSE ENSMUST00000103708.1 Traj33 U90517 uc288udg.1 uc288udg.2 uc288udg.1 uc288udg.2 
ENSMUST00000103709.2 Traj32 ENSMUST00000103709.2 Traj32 (from geneSymbol) A0A0G2JF50 A0A0G2JF50_MOUSE AF151730 ENSMUST00000103709.1 Traj32 uc288udh.1 uc288udh.2 uc288udh.1 uc288udh.2 
ENSMUST00000103710.2 Traj31 ENSMUST00000103710.2 Traj31 (from geneSymbol) A0A0G2JDF0 A0A0G2JDF0_MOUSE ENSMUST00000103710.1 Traj31 U86729 uc288udi.1 uc288udi.2 uc288udi.1 uc288udi.2 
ENSMUST00000103711.2 Traj30 ENSMUST00000103711.2 Traj30 (from geneSymbol) A0A0G2JDP5 A0A0G2JDP5_MOUSE ENSMUST00000103711.1 S53021 Traj30 uc288udj.1 uc288udj.2 uc288udj.1 uc288udj.2 
ENSMUST00000103712.2 Traj29 ENSMUST00000103712.2 Traj29 (from geneSymbol) A0A0G2JFV0 A0A0G2JFV0_MOUSE ENSMUST00000103712.1 Traj29 uc288udk.1 uc288udk.2 uc288udk.1 uc288udk.2 
ENSMUST00000103713.2 Traj28 ENSMUST00000103713.2 Traj28 (from geneSymbol) A0A0G2JFW3 A0A0G2JFW3_MOUSE ENSMUST00000103713.1 Traj28 uc288udl.1 uc288udl.2 uc288udl.1 uc288udl.2 
ENSMUST00000103714.2 Traj27 ENSMUST00000103714.2 Traj27 (from geneSymbol) A0A0G2JFL6 A0A0G2JFL6_MOUSE ENSMUST00000103714.1 Traj27 uc288udm.1 uc288udm.2 uc288udm.1 uc288udm.2 
ENSMUST00000103715.2 Traj26 ENSMUST00000103715.2 Traj26 (from geneSymbol) A0A0G2JGI7 A0A0G2JGI7_MOUSE ENSMUST00000103715.1 Traj26 uc288udn.1 uc288udn.2 uc288udn.1 uc288udn.2 
ENSMUST00000103716.3 Traj25 ENSMUST00000103716.3 Traj25 (from geneSymbol) A0A0G2JFP6 A0A0G2JFP6_MOUSE ENSMUST00000103716.1 ENSMUST00000103716.2 Traj25 uc288udo.1 uc288udo.2 uc288udo.1 uc288udo.2 
ENSMUST00000103717.3 Traj24 ENSMUST00000103717.3 Traj24 (from geneSymbol) A0A0G2JEV8 A0A0G2JEV8_MOUSE ENSMUST00000103717.1 ENSMUST00000103717.2 M38677 Traj24 uc288udp.1 uc288udp.2 uc288udp.1 uc288udp.2 
ENSMUST00000103718.2 Traj23 ENSMUST00000103718.2 Traj23 (from geneSymbol) A0A0G2JDS9 A0A0G2JDS9_MOUSE ENSMUST00000103718.1 Traj23 U89741 uc288udq.1 uc288udq.2 uc288udq.1 uc288udq.2 
ENSMUST00000103719.2 Traj22 ENSMUST00000103719.2 Traj22 (from geneSymbol) A0A0G2JDE9 A0A0G2JDE9_MOUSE AF151729 ENSMUST00000103719.1 Traj22 uc288udr.1 uc288udr.2 uc288udr.1 uc288udr.2 
ENSMUST00000103720.2 Traj21 ENSMUST00000103720.2 Traj21 (from geneSymbol) A0A0G2JG57 A0A0G2JG57_MOUSE ENSMUST00000103720.1 M61137 Traj21 uc288uds.1 uc288uds.2 uc288uds.1 uc288uds.2 
ENSMUST00000103721.3 Traj20 ENSMUST00000103721.3 Traj20 (from geneSymbol) A0A0G2JFK9 A0A0G2JFK9_MOUSE ENSMUST00000103721.1 ENSMUST00000103721.2 Traj20 uc288udt.1 uc288udt.2 uc288udt.1 uc288udt.2 
ENSMUST00000103722.2 Traj19 ENSMUST00000103722.2 Traj19 (from geneSymbol) A0A0G2JDX6 A0A0G2JDX6_MOUSE ENSMUST00000103722.1 Traj19 uc288udu.1 uc288udu.2 uc288udu.1 uc288udu.2 
ENSMUST00000103723.2 Traj18 ENSMUST00000103723.2 Traj18 (from geneSymbol) A0A0G2JG46 A0A0G2JG46_MOUSE ENSMUST00000103723.1 S53023 Traj18 uc288udv.1 uc288udv.2 uc288udv.1 uc288udv.2 
ENSMUST00000103724.2 Traj17 ENSMUST00000103724.2 Traj17 (from geneSymbol) A0A0G2JEC1 A0A0G2JEC1_MOUSE ENSMUST00000103724.1 Traj17 U92116 uc288udw.1 uc288udw.2 uc288udw.1 uc288udw.2 
ENSMUST00000103725.2 Traj16 ENSMUST00000103725.2 Traj16 (from geneSymbol) A0A0G2JEK3 A0A0G2JEK3_MOUSE ENSMUST00000103725.1 Traj16 uc288udx.1 uc288udx.2 uc288udx.1 uc288udx.2 
ENSMUST00000103726.2 Traj15 ENSMUST00000103726.2 Traj15 (from geneSymbol) A0A0G2JG86 A0A0G2JG86_MOUSE ENSMUST00000103726.1 Traj15 uc288udy.1 uc288udy.2 uc288udy.1 uc288udy.2 
ENSMUST00000103728.2 Traj13 ENSMUST00000103728.2 Traj13 (from geneSymbol) A0A0G2JER2 A0A0G2JER2_MOUSE ENSMUST00000103728.1 Traj13 U89739 uc288uea.1 uc288uea.2 uc288uea.1 uc288uea.2 
ENSMUST00000103729.2 Traj12 ENSMUST00000103729.2 Traj12 (from geneSymbol) A0A0G2JDG3 A0A0G2JDG3_MOUSE ENSMUST00000103729.1 Traj12 uc288ueb.1 uc288ueb.2 uc288ueb.1 uc288ueb.2 
ENSMUST00000103730.2 Traj11 ENSMUST00000103730.2 Traj11 (from geneSymbol) A0A0G2JE76 A0A0G2JE76_MOUSE ENSMUST00000103730.1 Traj11 U86727 uc288uec.1 uc288uec.2 uc288uec.1 uc288uec.2 
ENSMUST00000103731.2 Traj9 ENSMUST00000103731.2 Traj9 (from geneSymbol) A0A0G2JEW3 A0A0G2JEW3_MOUSE AF151731 ENSMUST00000103731.1 Traj9 uc288ued.1 uc288ued.2 uc288ued.1 uc288ued.2 
ENSMUST00000103733.2 Traj7 ENSMUST00000103733.2 Traj7 (from geneSymbol) A0A0G2JFF4 A0A0G2JFF4_MOUSE ENSMUST00000103733.1 S64073 Traj7 uc288uef.1 uc288uef.2 uc288uef.1 uc288uef.2 
ENSMUST00000103734.2 Traj6 ENSMUST00000103734.2 Traj6 (from geneSymbol) A0A0G2JEB4 A0A0G2JEB4_MOUSE ENSMUST00000103734.1 Traj6 uc288ueg.1 uc288ueg.2 uc288ueg.1 uc288ueg.2 
ENSMUST00000103735.2 Traj5 ENSMUST00000103735.2 Traj5 (from geneSymbol) A0A0G2JFC2 A0A0G2JFC2_MOUSE ENSMUST00000103735.1 Traj5 uc288ueh.1 uc288ueh.2 uc288ueh.1 uc288ueh.2 
ENSMUST00000103736.2 Traj4 ENSMUST00000103736.2 Traj4 (from geneSymbol) A0A0G2JF02 A0A0G2JF02_MOUSE ENSMUST00000103736.1 M61135 Traj4 uc288uei.1 uc288uei.2 uc288uei.1 uc288uei.2 
ENSMUST00000103737.3 Traj3 ENSMUST00000103737.3 Traj3 (from geneSymbol) A0A0G2JFD7 A0A0G2JFD7_MOUSE ENSMUST00000103737.1 ENSMUST00000103737.2 Traj3 uc288uej.1 uc288uej.2 uc288uej.1 uc288uej.2 
ENSMUST00000103738.2 Traj2 ENSMUST00000103738.2 Traj2 (from geneSymbol) A0A0G2JDE4 A0A0G2JDE4_MOUSE ENSMUST00000103738.1 Traj2 uc288uek.1 uc288uek.2 uc288uek.1 uc288uek.2 
ENSMUST00000103746.3 Iglv1 ENSMUST00000103746.3 Iglv1 (from geneSymbol) A0A075B663 A0A075B663_MOUSE AK008145 ENSMUST00000103746.1 ENSMUST00000103746.2 Iglv1 uc289dgq.1 uc289dgq.2 immunoglobulin production extracellular space immune response uc289dgq.1 uc289dgq.2 
ENSMUST00000103751.3 Iglv3 ENSMUST00000103751.3 Iglv3 (from geneSymbol) A0A0B4J1K5 A0A0B4J1K5_MOUSE ENSMUST00000103751.1 ENSMUST00000103751.2 Iglv3 M34598 uc289dgz.1 uc289dgz.2 immunoglobulin production extracellular space immune response uc289dgz.1 uc289dgz.2 
ENSMUST00000103758.4 Mir582 ENSMUST00000103758.4 microRNA 582 (from RefSeq NR_030644.1) ENSMUST00000103758.1 ENSMUST00000103758.2 ENSMUST00000103758.3 NR_030644 uc011zel.1 uc011zel.2 uc011zel.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610079.1 [ECO:0000345] ##Evidence-Data-END## uc011zel.1 uc011zel.2 uc011zel.3 
ENSMUST00000103760.4 Mir467e ENSMUST00000103760.4 microRNA 467e (from RefSeq NR_030645.1) ENSMUST00000103760.1 ENSMUST00000103760.2 ENSMUST00000103760.3 NR_030645 uc057lbt.1 uc057lbt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lbt.1 uc057lbt.2 
ENSMUST00000103768.4 Mir297a-3 ENSMUST00000103768.4 microRNA 297a-3 (from RefSeq NR_030551.1) ENSMUST00000103768.1 ENSMUST00000103768.2 ENSMUST00000103768.3 NR_030551 uc057lca.1 uc057lca.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lca.1 uc057lca.2 
ENSMUST00000103771.3 Mir669l ENSMUST00000103771.3 microRNA 669l (from RefSeq NR_130330.1) ENSMUST00000103771.1 ENSMUST00000103771.2 NR_130330 uc056zjn.1 uc056zjn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zjn.1 uc056zjn.2 
ENSMUST00000103778.4 Mir466b-1 ENSMUST00000103778.4 microRNA 466b-1 (from RefSeq NR_130319.1) ENSMUST00000103778.1 ENSMUST00000103778.2 ENSMUST00000103778.3 NR_130319 uc056zkl.1 uc056zkl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zkl.1 uc056zkl.2 
ENSMUST00000103784.4 Mir193b ENSMUST00000103784.4 microRNA 193b (from RefSeq NR_030549.1) ENSMUST00000103784.1 ENSMUST00000103784.2 ENSMUST00000103784.3 NR_030549 uc012abh.1 uc012abh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609918.1 [ECO:0000345] ##Evidence-Data-END## uc012abh.1 uc012abh.2 
ENSMUST00000103788.4 Mir297c ENSMUST00000103788.4 microRNA 297c (from RefSeq NR_030555.1) ENSMUST00000103788.1 ENSMUST00000103788.2 ENSMUST00000103788.3 NR_030555 uc057lbv.1 uc057lbv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lbv.1 uc057lbv.2 
ENSMUST00000103795.4 Mir297a-2 ENSMUST00000103795.4 microRNA 297a-2 (from RefSeq NR_029648.2) ENSMUST00000103795.1 ENSMUST00000103795.2 ENSMUST00000103795.3 NR_029648 uc057lbp.1 uc057lbp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lbp.1 uc057lbp.2 
ENSMUST00000103804.4 Mir466b-7 ENSMUST00000103804.4 microRNA 466b-7 (from RefSeq NR_130339.1) ENSMUST00000103804.1 ENSMUST00000103804.2 ENSMUST00000103804.3 NR_130339 uc056zkk.1 uc056zkk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zkk.1 uc056zkk.2 
ENSMUST00000103806.4 Mir466b-3 ENSMUST00000103806.4 microRNA 466b-3 (from RefSeq NR_030565.1) ENSMUST00000103806.1 ENSMUST00000103806.2 ENSMUST00000103806.3 NR_030565 uc056zkq.1 uc056zkq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zkq.1 uc056zkq.2 
ENSMUST00000103813.4 Mir544 ENSMUST00000103813.4 microRNA 544 (from RefSeq NR_030610.1) ENSMUST00000103813.1 ENSMUST00000103813.2 ENSMUST00000103813.3 NR_030610 uc056ysh.1 uc056ysh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc056ysh.1 uc056ysh.2 
ENSMUST00000103833.4 Mir467d ENSMUST00000103833.4 microRNA 467d (from RefSeq NR_030572.1) ENSMUST00000103833.1 ENSMUST00000103833.2 ENSMUST00000103833.3 NR_030572 uc012bqj.1 uc012bqj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609939.1 [ECO:0000345] ##Evidence-Data-END## uc012bqj.1 uc012bqj.2 
ENSMUST00000103837.4 Mir493 ENSMUST00000103837.4 microRNA 493 (from RefSeq NR_030573.1) ENSMUST00000103837.1 ENSMUST00000103837.2 ENSMUST00000103837.3 NR_030573 uc011yse.1 uc011yse.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc011yse.1 uc011yse.2 
ENSMUST00000103850.3 Mir669f ENSMUST00000103850.3 microRNA 669f (from RefSeq NR_130324.1) ENSMUST00000103850.1 ENSMUST00000103850.2 NR_130324 uc056zjj.1 uc056zjj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zjj.1 uc056zjj.2 
ENSMUST00000103854.4 Mir574 ENSMUST00000103854.4 microRNA 574 (from RefSeq NR_030577.1) ENSMUST00000103854.1 ENSMUST00000103854.2 ENSMUST00000103854.3 NR_030577 uc012dwo.1 uc012dwo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609942.1 [ECO:0000345] ##Evidence-Data-END## uc012dwo.1 uc012dwo.2 
ENSMUST00000103861.4 Mir467c ENSMUST00000103861.4 microRNA 467c (from RefSeq NR_030571.1) ENSMUST00000103861.1 ENSMUST00000103861.2 ENSMUST00000103861.3 NR_030571 uc056zjq.1 uc056zjq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zjq.1 uc056zjq.2 
ENSMUST00000103868.3 Mir669p-1 ENSMUST00000103868.3 microRNA 669p-1 (from RefSeq NR_037257.1) ENSMUST00000103868.1 ENSMUST00000103868.2 NR_037257 uc057lbs.1 uc057lbs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lbs.1 uc057lbs.2 
ENSMUST00000103883.4 Mir466b-8 ENSMUST00000103883.4 microRNA 466b-8 (from RefSeq NR_130341.1) ENSMUST00000103883.1 ENSMUST00000103883.2 ENSMUST00000103883.3 NR_130341 uc056zjt.1 uc056zjt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zjt.1 uc056zjt.2 
ENSMUST00000103884.3 Mir669p-2 ENSMUST00000103884.3 microRNA 669p-2 (from RefSeq NR_037262.1) ENSMUST00000103884.1 ENSMUST00000103884.2 NR_037262 uc057lbr.1 uc057lbr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lbr.1 uc057lbr.2 
ENSMUST00000103898.3 Mir669o ENSMUST00000103898.3 microRNA 669o (from RefSeq NR_130331.1) ENSMUST00000103898.1 ENSMUST00000103898.2 NR_130331 uc056zkw.1 uc056zkw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zkw.1 uc056zkw.2 
ENSMUST00000103900.4 Mir466b-5 ENSMUST00000103900.4 microRNA 466b-5 (from RefSeq NR_130337.1) ENSMUST00000103900.1 ENSMUST00000103900.2 ENSMUST00000103900.3 NR_130337 uc056zke.1 uc056zke.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zke.1 uc056zke.2 
ENSMUST00000103904.3 Mir742 ENSMUST00000103904.3 microRNA 742 (from RefSeq NR_030531.1) ENSMUST00000103904.1 ENSMUST00000103904.2 NR_030531 uc012hij.1 uc012hij.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609845.1 [ECO:0000345] ##Evidence-Data-END## uc012hij.1 uc012hij.2 
ENSMUST00000103919.3 Mir344c ENSMUST00000103919.3 microRNA 344c (from RefSeq NR_037286.1) ENSMUST00000103919.1 ENSMUST00000103919.2 NR_037286 uc012fmf.1 uc012fmf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610943.1 [ECO:0000345] ##Evidence-Data-END## uc012fmf.1 uc012fmf.2 
ENSMUST00000103923.4 Mir18b ENSMUST00000103923.4 microRNA 18b (from RefSeq NR_030548.1) ENSMUST00000103923.1 ENSMUST00000103923.2 ENSMUST00000103923.3 NR_030548 uc012hhh.1 uc012hhh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609917.1 [ECO:0000345] ##Evidence-Data-END## uc012hhh.1 uc012hhh.2 
ENSMUST00000103925.4 Mir466p ENSMUST00000103925.4 microRNA 466p (from RefSeq NR_105742.1) ENSMUST00000103925.1 ENSMUST00000103925.2 ENSMUST00000103925.3 NR_105742 uc057lbu.1 uc057lbu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lbu.1 uc057lbu.2 
ENSMUST00000103931.3 Mir741 ENSMUST00000103931.3 microRNA 741 (from RefSeq NR_030530.1) ENSMUST00000103931.1 ENSMUST00000103931.2 NR_030530 uc012hin.1 uc012hin.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609844.1 [ECO:0000345] ##Evidence-Data-END## uc012hin.1 uc012hin.2 
ENSMUST00000103939.3 Mir743 ENSMUST00000103939.3 microRNA 743 (from RefSeq NR_030532.1) ENSMUST00000103939.1 ENSMUST00000103939.2 NR_030532 uc012hih.1 uc012hih.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609846.1 [ECO:0000345] ##Evidence-Data-END## uc012hih.1 uc012hih.2 
ENSMUST00000103940.4 Mir465b-2 ENSMUST00000103940.4 microRNA 465b-2 (from RefSeq NR_030561.1) ENSMUST00000103940.1 ENSMUST00000103940.2 ENSMUST00000103940.3 NR_030561 uc012hiv.1 uc012hiv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012hiv.1 uc012hiv.2 
ENSMUST00000103954.3 Gm22937 ENSMUST00000103954.3 Gm22937 (from geneSymbol) ENSMUST00000103954.1 ENSMUST00000103954.2 uc287sbw.1 uc287sbw.2 uc287sbw.1 uc287sbw.2 
ENSMUST00000103955.3 Gm22936 ENSMUST00000103955.3 Gm22936 (from geneSymbol) ENSMUST00000103955.1 ENSMUST00000103955.2 uc290cgw.1 uc290cgw.2 uc290cgw.1 uc290cgw.2 
ENSMUST00000103956.3 Gm22938 ENSMUST00000103956.3 Gm22938 (from geneSymbol) ENSMUST00000103956.1 ENSMUST00000103956.2 uc292ixj.1 uc292ixj.2 uc292ixj.1 uc292ixj.2 
ENSMUST00000103958.3 Gm22939 ENSMUST00000103958.3 Gm22939 (from geneSymbol) ENSMUST00000103958.1 ENSMUST00000103958.2 uc291eaw.1 uc291eaw.2 uc291eaw.1 uc291eaw.2 
ENSMUST00000103960.3 Gm22935 ENSMUST00000103960.3 Gm22935 (from geneSymbol) ENSMUST00000103960.1 ENSMUST00000103960.2 LF193994 uc290gsr.1 uc290gsr.2 uc290gsr.1 uc290gsr.2 
ENSMUST00000103961.3 Gm22934 ENSMUST00000103961.3 Gm22934 (from geneSymbol) ENSMUST00000103961.1 ENSMUST00000103961.2 uc291scg.1 uc291scg.2 uc291scg.1 uc291scg.2 
ENSMUST00000103962.3 Gm24581 ENSMUST00000103962.3 Gm24581 (from geneSymbol) ENSMUST00000103962.1 ENSMUST00000103962.2 uc291wnn.1 uc291wnn.2 uc291wnn.1 uc291wnn.2 
ENSMUST00000103964.4 Gm24579 ENSMUST00000103964.4 Gm24579 (from geneSymbol) ENSMUST00000103964.1 ENSMUST00000103964.2 ENSMUST00000103964.3 uc289cgu.1 uc289cgu.2 uc289cgu.1 uc289cgu.2 
ENSMUST00000103965.3 Gm24580 ENSMUST00000103965.3 Gm24580 (from geneSymbol) ENSMUST00000103965.1 ENSMUST00000103965.2 uc292afe.1 uc292afe.2 uc292afe.1 uc292afe.2 
ENSMUST00000103967.3 Gm24582 ENSMUST00000103967.3 Gm24582 (from geneSymbol) ENSMUST00000103967.1 ENSMUST00000103967.2 uc287yib.1 uc287yib.2 uc287yib.1 uc287yib.2 
ENSMUST00000103970.3 Gm24578 ENSMUST00000103970.3 Gm24578 (from geneSymbol) ENSMUST00000103970.1 ENSMUST00000103970.2 uc288qug.1 uc288qug.2 uc288qug.1 uc288qug.2 
ENSMUST00000103972.3 Gm24118 ENSMUST00000103972.3 Gm24118 (from geneSymbol) ENSMUST00000103972.1 ENSMUST00000103972.2 uc288usz.1 uc288usz.2 uc288usz.1 uc288usz.2 
ENSMUST00000103973.4 Gm24117 ENSMUST00000103973.4 Gm24117 (from geneSymbol) ENSMUST00000103973.1 ENSMUST00000103973.2 ENSMUST00000103973.3 uc290ndt.1 uc290ndt.2 uc290ndt.1 uc290ndt.2 
ENSMUST00000103975.4 Gm24116 ENSMUST00000103975.4 Gm24116 (from geneSymbol) ENSMUST00000103975.1 ENSMUST00000103975.2 ENSMUST00000103975.3 uc291qje.1 uc291qje.2 uc291qje.1 uc291qje.2 
ENSMUST00000103976.3 Gm23923 ENSMUST00000103976.3 Gm23923 (from geneSymbol) ENSMUST00000103976.1 ENSMUST00000103976.2 uc288kof.1 uc288kof.2 uc288kof.1 uc288kof.2 
ENSMUST00000103978.3 Gm24120 ENSMUST00000103978.3 Gm24120 (from geneSymbol) ENSMUST00000103978.1 ENSMUST00000103978.2 uc291rgy.1 uc291rgy.2 uc291rgy.1 uc291rgy.2 
ENSMUST00000103979.3 Gm24119 ENSMUST00000103979.3 Gm24119 (from geneSymbol) ENSMUST00000103979.1 ENSMUST00000103979.2 uc287ubl.1 uc287ubl.2 uc287ubl.1 uc287ubl.2 
ENSMUST00000103981.3 Gm25396 ENSMUST00000103981.3 Gm25396 (from geneSymbol) ENSMUST00000103981.1 ENSMUST00000103981.2 uc289ome.1 uc289ome.2 uc289ome.1 uc289ome.2 
ENSMUST00000103983.3 Gm25761 ENSMUST00000103983.3 Gm25761 (from geneSymbol) ENSMUST00000103983.1 ENSMUST00000103983.2 uc290tip.1 uc290tip.2 uc290tip.1 uc290tip.2 
ENSMUST00000103984.3 Gm25762 ENSMUST00000103984.3 Gm25762 (from geneSymbol) ENSMUST00000103984.1 ENSMUST00000103984.2 uc289dhi.1 uc289dhi.2 uc289dhi.1 uc289dhi.2 
ENSMUST00000103986.3 Gm25757 ENSMUST00000103986.3 Gm25757 (from geneSymbol) ENSMUST00000103986.1 ENSMUST00000103986.2 uc290krt.1 uc290krt.2 uc290krt.1 uc290krt.2 
ENSMUST00000103987.3 Gm25758 ENSMUST00000103987.3 Gm25758 (from geneSymbol) ENSMUST00000103987.1 ENSMUST00000103987.2 uc290wxs.1 uc290wxs.2 uc290wxs.1 uc290wxs.2 
ENSMUST00000103988.3 Gm25759 ENSMUST00000103988.3 Gm25759 (from geneSymbol) ENSMUST00000103988.1 ENSMUST00000103988.2 uc291vgt.1 uc291vgt.2 uc291vgt.1 uc291vgt.2 
ENSMUST00000103989.3 Gm25760 ENSMUST00000103989.3 Gm25760 (from geneSymbol) ENSMUST00000103989.1 ENSMUST00000103989.2 uc288gms.1 uc288gms.2 uc288gms.1 uc288gms.2 
ENSMUST00000103990.3 Gm25756 ENSMUST00000103990.3 Gm25756 (from geneSymbol) ENSMUST00000103990.1 ENSMUST00000103990.2 uc290wqb.1 uc290wqb.2 uc290wqb.1 uc290wqb.2 
ENSMUST00000103992.3 Gm25094 ENSMUST00000103992.3 Gm25094 (from geneSymbol) ENSMUST00000103992.1 ENSMUST00000103992.2 uc291hfz.1 uc291hfz.2 uc291hfz.1 uc291hfz.2 
ENSMUST00000103993.3 Gm25093 ENSMUST00000103993.3 Gm25093 (from geneSymbol) ENSMUST00000103993.1 ENSMUST00000103993.2 uc288xxd.1 uc288xxd.2 uc288xxd.1 uc288xxd.2 
ENSMUST00000103996.4 Gm25092 ENSMUST00000103996.4 Gm25092 (from geneSymbol) ENSMUST00000103996.1 ENSMUST00000103996.2 ENSMUST00000103996.3 uc289hwl.1 uc289hwl.2 uc289hwl.1 uc289hwl.2 
ENSMUST00000103997.3 Gm25091 ENSMUST00000103997.3 Gm25091 (from geneSymbol) ENSMUST00000103997.1 ENSMUST00000103997.2 uc291buq.1 uc291buq.2 uc291buq.1 uc291buq.2 
ENSMUST00000104003.3 Snord64 ENSMUST00000104003.3 small nucleolar RNA, C/D box 64 (from RefSeq NR_028529.1) ENSMUST00000104003.1 ENSMUST00000104003.2 NR_028529 uc291qvt.1 uc291qvt.2 uc291qvt.1 uc291qvt.2 
ENSMUST00000104004.5 Snora17 ENSMUST00000104004.5 small nucleolar RNA, H/ACA box 17 (from RefSeq NR_028571.1) ENSMUST00000104004.1 ENSMUST00000104004.2 ENSMUST00000104004.3 ENSMUST00000104004.4 NR_028571 uc029twf.1 uc029twf.2 uc029twf.1 uc029twf.2 
ENSMUST00000104006.3 Gm23431 ENSMUST00000104006.3 Gm23431 (from geneSymbol) ENSMUST00000104006.1 ENSMUST00000104006.2 uc291qwy.1 uc291qwy.2 uc291qwy.1 uc291qwy.2 
ENSMUST00000104007.3 Gm24796 ENSMUST00000104007.3 Gm24796 (from geneSymbol) ENSMUST00000104007.1 ENSMUST00000104007.2 uc290nua.1 uc290nua.2 uc290nua.1 uc290nua.2 
ENSMUST00000104008.3 Gm22267 ENSMUST00000104008.3 Gm22267 (from geneSymbol) ENSMUST00000104008.1 ENSMUST00000104008.2 uc291cxu.1 uc291cxu.2 uc291cxu.1 uc291cxu.2 
ENSMUST00000104009.3 Gm22268 ENSMUST00000104009.3 Gm22268 (from geneSymbol) ENSMUST00000104009.1 ENSMUST00000104009.2 uc289fnq.1 uc289fnq.2 uc289fnq.1 uc289fnq.2 
ENSMUST00000104011.5 Gm22266 ENSMUST00000104011.5 Gm22266 (from geneSymbol) ENSMUST00000104011.1 ENSMUST00000104011.2 ENSMUST00000104011.3 ENSMUST00000104011.4 uc292pyc.1 uc292pyc.2 uc292pyc.1 uc292pyc.2 
ENSMUST00000104012.3 Gm25613 ENSMUST00000104012.3 Gm25613 (from geneSymbol) ENSMUST00000104012.1 ENSMUST00000104012.2 uc287qqk.1 uc287qqk.2 uc287qqk.1 uc287qqk.2 
ENSMUST00000104013.3 Gm25614 ENSMUST00000104013.3 Gm25614 (from geneSymbol) ENSMUST00000104013.1 ENSMUST00000104013.2 uc288uwt.1 uc288uwt.2 uc288uwt.1 uc288uwt.2 
ENSMUST00000104014.3 Gm25612 ENSMUST00000104014.3 Gm25612 (from geneSymbol) ENSMUST00000104014.1 ENSMUST00000104014.2 uc287lxa.1 uc287lxa.2 uc287lxa.1 uc287lxa.2 
ENSMUST00000104016.3 Gm25610 ENSMUST00000104016.3 Gm25610 (from geneSymbol) ENSMUST00000104016.1 ENSMUST00000104016.2 uc288eyb.1 uc288eyb.2 uc288eyb.1 uc288eyb.2 
ENSMUST00000104017.3 Gm25611 ENSMUST00000104017.3 Gm25611 (from geneSymbol) ENSMUST00000104017.1 ENSMUST00000104017.2 uc289rtb.1 uc289rtb.2 uc289rtb.1 uc289rtb.2 
ENSMUST00000104019.3 Gm25609 ENSMUST00000104019.3 Gm25609 (from geneSymbol) ENSMUST00000104019.1 ENSMUST00000104019.2 uc287mdl.1 uc287mdl.2 uc287mdl.1 uc287mdl.2 
ENSMUST00000104020.3 Gm25607 ENSMUST00000104020.3 Gm25607 (from geneSymbol) ENSMUST00000104020.1 ENSMUST00000104020.2 uc292jwm.1 uc292jwm.2 uc292jwm.1 uc292jwm.2 
ENSMUST00000104021.3 Gm25608 ENSMUST00000104021.3 Gm25608 (from geneSymbol) ENSMUST00000104021.1 ENSMUST00000104021.2 uc290vsu.1 uc290vsu.2 uc290vsu.1 uc290vsu.2 
ENSMUST00000104024.3 Snord69 ENSMUST00000104024.3 small nucleolar RNA, C/D box 69 (from RefSeq NR_028531.1) ENSMUST00000104024.1 ENSMUST00000104024.2 NR_028531 uc288rzl.1 uc288rzl.2 uc288rzl.1 uc288rzl.2 
ENSMUST00000104026.3 Gm23950 ENSMUST00000104026.3 Gm23950 (from geneSymbol) ENSMUST00000104026.1 ENSMUST00000104026.2 uc290nfe.1 uc290nfe.2 uc290nfe.1 uc290nfe.2 
ENSMUST00000104027.3 Gm23949 ENSMUST00000104027.3 Gm23949 (from geneSymbol) ENSMUST00000104027.1 ENSMUST00000104027.2 uc292jzd.1 uc292jzd.2 uc292jzd.1 uc292jzd.2 
ENSMUST00000104029.3 Gm23951 ENSMUST00000104029.3 Gm23951 (from geneSymbol) ENSMUST00000104029.1 ENSMUST00000104029.2 uc288awp.1 uc288awp.2 uc288awp.1 uc288awp.2 
ENSMUST00000104032.3 Snord78 ENSMUST00000104032.3 Snord78 (from geneSymbol) ENSMUST00000104032.1 ENSMUST00000104032.2 uc287nce.1 uc287nce.2 uc287nce.1 uc287nce.2 
ENSMUST00000104033.3 Snord67 ENSMUST00000104033.3 small nucleolar RNA, C/D box 67 (from RefSeq NR_028553.1) ENSMUST00000104033.1 ENSMUST00000104033.2 NR_028553 uc012bzi.1 uc012bzi.2 uc012bzi.3 uc012bzi.1 uc012bzi.2 uc012bzi.3 
ENSMUST00000104034.3 Gm22270 ENSMUST00000104034.3 Gm22270 (from geneSymbol) ENSMUST00000104034.1 ENSMUST00000104034.2 uc290xxe.1 uc290xxe.2 uc290xxe.1 uc290xxe.2 
ENSMUST00000104035.3 Gm22271 ENSMUST00000104035.3 Gm22271 (from geneSymbol) ENSMUST00000104035.1 ENSMUST00000104035.2 uc289slf.1 uc289slf.2 uc289slf.1 uc289slf.2 
ENSMUST00000104036.3 Gm23437 ENSMUST00000104036.3 Gm23437 (from geneSymbol) ENSMUST00000104036.1 ENSMUST00000104036.2 uc288wjh.1 uc288wjh.2 uc288wjh.1 uc288wjh.2 
ENSMUST00000104039.3 Gm22272 ENSMUST00000104039.3 Gm22272 (from geneSymbol) ENSMUST00000104039.1 ENSMUST00000104039.2 uc289rag.1 uc289rag.2 uc289rag.1 uc289rag.2 
ENSMUST00000104040.3 Gm22273 ENSMUST00000104040.3 Gm22273 (from geneSymbol) ENSMUST00000104040.1 ENSMUST00000104040.2 uc290vrx.1 uc290vrx.2 uc290vrx.1 uc290vrx.2 
ENSMUST00000104042.3 Gm25097 ENSMUST00000104042.3 Gm25097 (from geneSymbol) ENSMUST00000104042.1 ENSMUST00000104042.2 uc292qyl.1 uc292qyl.2 uc292qyl.1 uc292qyl.2 
ENSMUST00000104043.3 Gm25096 ENSMUST00000104043.3 Gm25096 (from geneSymbol) ENSMUST00000104043.1 ENSMUST00000104043.2 uc287hfp.1 uc287hfp.2 uc287hfp.1 uc287hfp.2 
ENSMUST00000104047.3 Gm25095 ENSMUST00000104047.3 Gm25095 (from geneSymbol) ENSMUST00000104047.1 ENSMUST00000104047.2 uc287ovr.1 uc287ovr.2 uc287ovr.1 uc287ovr.2 
ENSMUST00000104049.3 Gm22438 ENSMUST00000104049.3 Gm22438 (from geneSymbol) ENSMUST00000104049.1 ENSMUST00000104049.2 uc287kym.1 uc287kym.2 uc287kym.1 uc287kym.2 
ENSMUST00000104051.3 Snord66 ENSMUST00000104051.3 small nucleolar RNA, C/D box 66 (from RefSeq NR_028530.1) ENSMUST00000104051.1 ENSMUST00000104051.2 NR_028530 uc012acz.1 uc012acz.2 uc012acz.3 uc012acz.1 uc012acz.2 uc012acz.3 
ENSMUST00000104052.3 Gm23271 ENSMUST00000104052.3 Gm23271 (from geneSymbol) ENSMUST00000104052.1 ENSMUST00000104052.2 uc292fyi.1 uc292fyi.2 uc292fyi.1 uc292fyi.2 
ENSMUST00000104053.4 Gm23272 ENSMUST00000104053.4 Gm23272 (from geneSymbol) ENSMUST00000104053.1 ENSMUST00000104053.2 ENSMUST00000104053.3 uc291kcp.1 uc291kcp.2 uc291kcp.1 uc291kcp.2 
ENSMUST00000104055.3 Gm23270 ENSMUST00000104055.3 Gm23270 (from geneSymbol) ENSMUST00000104055.1 ENSMUST00000104055.2 uc289pfg.1 uc289pfg.2 uc289pfg.1 uc289pfg.2 
ENSMUST00000104056.3 Gm23274 ENSMUST00000104056.3 Gm23274 (from geneSymbol) ENSMUST00000104056.1 ENSMUST00000104056.2 uc287ghu.1 uc287ghu.2 uc287ghu.1 uc287ghu.2 
ENSMUST00000104058.3 Gm23273 ENSMUST00000104058.3 Gm23273 (from geneSymbol) ENSMUST00000104058.1 ENSMUST00000104058.2 uc291dnn.1 uc291dnn.2 uc291dnn.1 uc291dnn.2 
ENSMUST00000104059.3 Gm24263 ENSMUST00000104059.3 Gm24263 (from geneSymbol) ENSMUST00000104059.1 ENSMUST00000104059.2 uc289rku.1 uc289rku.2 uc289rku.1 uc289rku.2 
ENSMUST00000104060.2 Gm23275 ENSMUST00000104060.2 Gm23275 (from geneSymbol) ENSMUST00000104060.1 uc292egn.1 uc292egn.2 uc292egn.1 uc292egn.2 
ENSMUST00000104062.2 Gm26075 ENSMUST00000104062.2 Gm26075 (from geneSymbol) ENSMUST00000104062.1 uc291cmo.1 uc291cmo.2 uc291cmo.1 uc291cmo.2 
ENSMUST00000104063.3 Gm26074 ENSMUST00000104063.3 Gm26074 (from geneSymbol) ENSMUST00000104063.1 ENSMUST00000104063.2 uc289etf.1 uc289etf.2 uc289etf.1 uc289etf.2 
ENSMUST00000104064.3 Gm26077 ENSMUST00000104064.3 Gm26077 (from geneSymbol) ENSMUST00000104064.1 ENSMUST00000104064.2 uc287nzn.1 uc287nzn.2 uc287nzn.1 uc287nzn.2 
ENSMUST00000104065.3 Gm26076 ENSMUST00000104065.3 Gm26076 (from geneSymbol) ENSMUST00000104065.1 ENSMUST00000104065.2 uc290iwd.1 uc290iwd.2 uc290iwd.1 uc290iwd.2 
ENSMUST00000104066.3 Gm26079 ENSMUST00000104066.3 Gm26079 (from geneSymbol) ENSMUST00000104066.1 ENSMUST00000104066.2 uc290ygg.1 uc290ygg.2 uc290ygg.1 uc290ygg.2 
ENSMUST00000104067.3 Gm26078 ENSMUST00000104067.3 Gm26078 (from geneSymbol) ENSMUST00000104067.1 ENSMUST00000104067.2 uc287krx.1 uc287krx.2 uc287krx.1 uc287krx.2 
ENSMUST00000104068.3 Gm26081 ENSMUST00000104068.3 Gm26081 (from geneSymbol) ENSMUST00000104068.1 ENSMUST00000104068.2 uc290ezw.1 uc290ezw.2 uc290ezw.1 uc290ezw.2 
ENSMUST00000104069.3 Gm26080 ENSMUST00000104069.3 Gm26080 (from geneSymbol) ENSMUST00000104069.1 ENSMUST00000104069.2 uc287lch.1 uc287lch.2 uc287lch.1 uc287lch.2 
ENSMUST00000104070.4 Gm26082 ENSMUST00000104070.4 Gm26082 (from geneSymbol) ENSMUST00000104070.1 ENSMUST00000104070.2 ENSMUST00000104070.3 uc292jmd.1 uc292jmd.2 uc292jmd.1 uc292jmd.2 
ENSMUST00000104071.3 Gm23979 ENSMUST00000104071.3 Gm23979 (from geneSymbol) ENSMUST00000104071.1 ENSMUST00000104071.2 uc288evp.1 uc288evp.2 uc288evp.1 uc288evp.2 
ENSMUST00000104072.3 Gm24869 ENSMUST00000104072.3 Gm24869 (from geneSymbol) ENSMUST00000104072.1 ENSMUST00000104072.2 uc290odd.1 uc290odd.2 uc290odd.1 uc290odd.2 
ENSMUST00000104075.4 Gm24432 ENSMUST00000104075.4 Gm24432 (from geneSymbol) ENSMUST00000104075.1 ENSMUST00000104075.2 ENSMUST00000104075.3 uc289opg.1 uc289opg.2 uc289opg.1 uc289opg.2 
ENSMUST00000104076.3 Gm24429 ENSMUST00000104076.3 Gm24429 (from geneSymbol) ENSMUST00000104076.1 ENSMUST00000104076.2 uc288fxd.1 uc288fxd.2 uc288fxd.1 uc288fxd.2 
ENSMUST00000104077.3 Gm24430 ENSMUST00000104077.3 Gm24430 (from geneSymbol) ENSMUST00000104077.1 ENSMUST00000104077.2 uc287ttm.1 uc287ttm.2 uc287ttm.1 uc287ttm.2 
ENSMUST00000104080.3 Gm24433 ENSMUST00000104080.3 Gm24433 (from geneSymbol) ENSMUST00000104080.1 ENSMUST00000104080.2 uc287uiv.1 uc287uiv.2 uc287uiv.1 uc287uiv.2 
ENSMUST00000104081.3 Gm24434 ENSMUST00000104081.3 Gm24434 (from geneSymbol) ENSMUST00000104081.1 ENSMUST00000104081.2 uc288gax.1 uc288gax.2 uc288gax.1 uc288gax.2 
ENSMUST00000104082.3 Gm22782 ENSMUST00000104082.3 Gm22782 (from geneSymbol) ENSMUST00000104082.1 ENSMUST00000104082.2 uc288gub.1 uc288gub.2 uc288gub.1 uc288gub.2 
ENSMUST00000104083.2 Gm22781 ENSMUST00000104083.2 Gm22781 (from geneSymbol) ENSMUST00000104083.1 uc290kyy.1 uc290kyy.2 uc290kyy.1 uc290kyy.2 
ENSMUST00000104085.3 Gm22779 ENSMUST00000104085.3 Gm22779 (from geneSymbol) ENSMUST00000104085.1 ENSMUST00000104085.2 uc290vbr.1 uc290vbr.2 uc290vbr.1 uc290vbr.2 
ENSMUST00000104086.3 Gm22786 ENSMUST00000104086.3 Gm22786 (from geneSymbol) ENSMUST00000104086.1 ENSMUST00000104086.2 uc287jzd.1 uc287jzd.2 uc287jzd.1 uc287jzd.2 
ENSMUST00000104087.3 Gm22785 ENSMUST00000104087.3 Gm22785 (from geneSymbol) ENSMUST00000104087.1 ENSMUST00000104087.2 uc292onm.1 uc292onm.2 uc292onm.1 uc292onm.2 
ENSMUST00000104088.3 Gm22784 ENSMUST00000104088.3 Gm22784 (from geneSymbol) ENSMUST00000104088.1 ENSMUST00000104088.2 uc290fjj.1 uc290fjj.2 uc290fjj.1 uc290fjj.2 
ENSMUST00000104089.3 Gm22783 ENSMUST00000104089.3 Gm22783 (from geneSymbol) ENSMUST00000104089.1 ENSMUST00000104089.2 uc292njo.1 uc292njo.2 uc292njo.1 uc292njo.2 
ENSMUST00000104090.3 Gm22778 ENSMUST00000104090.3 Gm22778 (from geneSymbol) ENSMUST00000104090.1 ENSMUST00000104090.2 uc288pbv.1 uc288pbv.2 uc288pbv.1 uc288pbv.2 
ENSMUST00000104091.3 Gm22777 ENSMUST00000104091.3 Gm22777 (from geneSymbol) ENSMUST00000104091.1 ENSMUST00000104091.2 uc288nex.1 uc288nex.2 uc288nex.1 uc288nex.2 
ENSMUST00000104092.3 Gm25764 ENSMUST00000104092.3 Gm25764 (from geneSymbol) ENSMUST00000104092.1 ENSMUST00000104092.2 uc287vxl.1 uc287vxl.2 uc287vxl.1 uc287vxl.2 
ENSMUST00000104094.3 Gm26395 ENSMUST00000104094.3 Gm26395 (from geneSymbol) ENSMUST00000104094.1 ENSMUST00000104094.2 uc288max.1 uc288max.2 uc288max.1 uc288max.2 
ENSMUST00000104098.4 Gm25076 ENSMUST00000104098.4 Gm25076 (from geneSymbol) ENSMUST00000104098.1 ENSMUST00000104098.2 ENSMUST00000104098.3 uc290yzy.1 uc290yzy.2 uc290yzy.1 uc290yzy.2 
ENSMUST00000104099.3 Gm25763 ENSMUST00000104099.3 Gm25763 (from geneSymbol) ENSMUST00000104099.1 ENSMUST00000104099.2 uc291ynn.1 uc291ynn.2 uc291ynn.1 uc291ynn.2 
ENSMUST00000104100.3 Gm25765 ENSMUST00000104100.3 Gm25765 (from geneSymbol) ENSMUST00000104100.1 ENSMUST00000104100.2 uc290wrz.1 uc290wrz.2 uc290wrz.1 uc290wrz.2 
ENSMUST00000104101.3 Gm25766 ENSMUST00000104101.3 Gm25766 (from geneSymbol) ENSMUST00000104101.1 ENSMUST00000104101.2 uc292dhz.1 uc292dhz.2 uc292dhz.1 uc292dhz.2 
ENSMUST00000104102.3 Gm25407 ENSMUST00000104102.3 Gm25407 (from geneSymbol) ENSMUST00000104102.1 ENSMUST00000104102.2 uc290cby.1 uc290cby.2 uc290cby.1 uc290cby.2 
ENSMUST00000104103.3 Gm24124 ENSMUST00000104103.3 Gm24124 (from geneSymbol) ENSMUST00000104103.1 ENSMUST00000104103.2 uc289rgg.1 uc289rgg.2 uc289rgg.1 uc289rgg.2 
ENSMUST00000104104.3 Gm25408 ENSMUST00000104104.3 Gm25408 (from geneSymbol) ENSMUST00000104104.1 ENSMUST00000104104.2 uc288fsr.1 uc288fsr.2 uc288fsr.1 uc288fsr.2 
ENSMUST00000104105.2 Gm24125 ENSMUST00000104105.2 Gm24125 (from geneSymbol) ENSMUST00000104105.1 uc290kzd.1 uc290kzd.2 uc290kzd.1 uc290kzd.2 
ENSMUST00000104106.3 Gm24123 ENSMUST00000104106.3 Gm24123 (from geneSymbol) ENSMUST00000104106.1 ENSMUST00000104106.2 uc292pke.1 uc292pke.2 uc292pke.1 uc292pke.2 
ENSMUST00000104107.3 Gm24122 ENSMUST00000104107.3 Gm24122 (from geneSymbol) ENSMUST00000104107.1 ENSMUST00000104107.2 uc287kur.1 uc287kur.2 uc287kur.1 uc287kur.2 
ENSMUST00000104108.3 Gm22115 ENSMUST00000104108.3 Gm22115 (from geneSymbol) ENSMUST00000104108.1 ENSMUST00000104108.2 uc288kog.1 uc288kog.2 uc288kog.1 uc288kog.2 
ENSMUST00000104110.3 Gm24127 ENSMUST00000104110.3 Gm24127 (from geneSymbol) ENSMUST00000104110.1 ENSMUST00000104110.2 uc288waz.1 uc288waz.2 uc288waz.1 uc288waz.2 
ENSMUST00000104111.3 Gm24126 ENSMUST00000104111.3 Gm24126 (from geneSymbol) ENSMUST00000104111.1 ENSMUST00000104111.2 uc289mxw.1 uc289mxw.2 uc289mxw.1 uc289mxw.2 
ENSMUST00000104114.2 Gm22473 ENSMUST00000104114.2 Gm22473 (from geneSymbol) ENSMUST00000104114.1 uc290lbi.1 uc290lbi.2 uc290lbi.1 uc290lbi.2 
ENSMUST00000104115.3 Gm22472 ENSMUST00000104115.3 Gm22472 (from geneSymbol) ENSMUST00000104115.1 ENSMUST00000104115.2 uc292pre.1 uc292pre.2 uc292pre.1 uc292pre.2 
ENSMUST00000104116.3 Gm22471 ENSMUST00000104116.3 Gm22471 (from geneSymbol) ENSMUST00000104116.1 ENSMUST00000104116.2 uc287wkn.1 uc287wkn.2 uc287wkn.1 uc287wkn.2 
ENSMUST00000104117.3 Gm22470 ENSMUST00000104117.3 Gm22470 (from geneSymbol) ENSMUST00000104117.1 ENSMUST00000104117.2 uc289ofy.1 uc289ofy.2 uc289ofy.1 uc289ofy.2 
ENSMUST00000104118.3 Gm22469 ENSMUST00000104118.3 Gm22469 (from geneSymbol) ENSMUST00000104118.1 ENSMUST00000104118.2 uc288slr.1 uc288slr.2 uc288slr.1 uc288slr.2 
ENSMUST00000104120.2 Gm25485 ENSMUST00000104120.2 Gm25485 (from geneSymbol) ENSMUST00000104120.1 uc290mru.1 uc290mru.2 uc290mru.1 uc290mru.2 
ENSMUST00000104123.4 Gm25311 ENSMUST00000104123.4 Gm25311 (from geneSymbol) ENSMUST00000104123.1 ENSMUST00000104123.2 ENSMUST00000104123.3 uc291esd.1 uc291esd.2 uc291esd.1 uc291esd.2 
ENSMUST00000104124.3 Gm24170 ENSMUST00000104124.3 Gm24170 (from geneSymbol) ENSMUST00000104124.1 ENSMUST00000104124.2 uc290nho.1 uc290nho.2 uc290nho.1 uc290nho.2 
ENSMUST00000104126.3 Gm24171 ENSMUST00000104126.3 Gm24171 (from geneSymbol) ENSMUST00000104126.1 ENSMUST00000104126.2 uc287gty.1 uc287gty.2 uc287gty.1 uc287gty.2 
ENSMUST00000104127.4 Gm24172 ENSMUST00000104127.4 Gm24172 (from geneSymbol) ENSMUST00000104127.1 ENSMUST00000104127.2 ENSMUST00000104127.3 uc287rxe.1 uc287rxe.2 uc287rxe.1 uc287rxe.2 
ENSMUST00000104129.3 Gm25785 ENSMUST00000104129.3 Gm25785 (from geneSymbol) ENSMUST00000104129.1 ENSMUST00000104129.2 uc289pda.1 uc289pda.2 uc289pda.1 uc289pda.2 
ENSMUST00000104130.3 Gm24173 ENSMUST00000104130.3 Gm24173 (from geneSymbol) ENSMUST00000104130.1 ENSMUST00000104130.2 uc287gmt.1 uc287gmt.2 uc287gmt.1 uc287gmt.2 
ENSMUST00000104132.3 Gm22284 ENSMUST00000104132.3 Gm22284 (from geneSymbol) ENSMUST00000104132.1 ENSMUST00000104132.2 uc287xoz.1 uc287xoz.2 uc287xoz.1 uc287xoz.2 
ENSMUST00000104135.3 Rnu11 ENSMUST00000104135.3 U11 small nuclear RNA (from RefSeq NR_002865.2) ENSMUST00000104135.1 ENSMUST00000104135.2 NR_002865 uc008vaw.1 uc008vaw.2 uc008vaw.3 uc008vaw.1 uc008vaw.2 uc008vaw.3 
ENSMUST00000104136.4 Gm24709 ENSMUST00000104136.4 Gm24709 (from geneSymbol) ENSMUST00000104136.1 ENSMUST00000104136.2 ENSMUST00000104136.3 uc291isk.1 uc291isk.2 uc291isk.1 uc291isk.2 
ENSMUST00000104137.3 Gm25833 ENSMUST00000104137.3 Gm25833 (from geneSymbol) ENSMUST00000104137.1 ENSMUST00000104137.2 uc291fik.1 uc291fik.2 uc291fik.1 uc291fik.2 
ENSMUST00000104139.3 Gm25938 ENSMUST00000104139.3 Gm25938 (from geneSymbol) ENSMUST00000104139.1 ENSMUST00000104139.2 uc290roa.1 uc290roa.2 uc290roa.1 uc290roa.2 
ENSMUST00000104140.3 Gm25832 ENSMUST00000104140.3 Gm25832 (from geneSymbol) ENSMUST00000104140.1 ENSMUST00000104140.2 uc287ixq.1 uc287ixq.2 uc287ixq.1 uc287ixq.2 
ENSMUST00000104144.3 Gm23014 ENSMUST00000104144.3 Gm23014 (from geneSymbol) ENSMUST00000104144.1 ENSMUST00000104144.2 uc291gho.1 uc291gho.2 uc291gho.1 uc291gho.2 
ENSMUST00000104145.3 Gm23015 ENSMUST00000104145.3 Gm23015 (from geneSymbol) ENSMUST00000104145.1 ENSMUST00000104145.2 uc290vpu.1 uc290vpu.2 uc290vpu.1 uc290vpu.2 
ENSMUST00000104146.4 Gm23013 ENSMUST00000104146.4 Gm23013 (from geneSymbol) ENSMUST00000104146.1 ENSMUST00000104146.2 ENSMUST00000104146.3 uc291cpl.1 uc291cpl.2 uc291cpl.1 uc291cpl.2 
ENSMUST00000104148.3 Gm23011 ENSMUST00000104148.3 Gm23011 (from geneSymbol) ENSMUST00000104148.1 ENSMUST00000104148.2 uc290jvp.1 uc290jvp.2 uc290jvp.1 uc290jvp.2 
ENSMUST00000104149.4 Gm23012 ENSMUST00000104149.4 Gm23012 (from geneSymbol) ENSMUST00000104149.1 ENSMUST00000104149.2 ENSMUST00000104149.3 uc288oqm.1 uc288oqm.2 uc288oqm.1 uc288oqm.2 
ENSMUST00000104150.3 Gm23294 ENSMUST00000104150.3 Gm23294 (from geneSymbol) ENSMUST00000104150.1 ENSMUST00000104150.2 LF201027 uc289jry.1 uc289jry.2 uc289jry.1 uc289jry.2 
ENSMUST00000104151.3 Gm23010 ENSMUST00000104151.3 Gm23010 (from geneSymbol) ENSMUST00000104151.1 ENSMUST00000104151.2 uc291dqm.1 uc291dqm.2 uc291dqm.1 uc291dqm.2 
ENSMUST00000104152.4 Gm23311 ENSMUST00000104152.4 Gm23311 (from geneSymbol) ENSMUST00000104152.1 ENSMUST00000104152.2 ENSMUST00000104152.3 uc287zuu.1 uc287zuu.2 uc287zuu.1 uc287zuu.2 
ENSMUST00000104154.3 Gm24670 ENSMUST00000104154.3 Gm24670 (from geneSymbol) ENSMUST00000104154.1 ENSMUST00000104154.2 uc289tkq.1 uc289tkq.2 uc289tkq.1 uc289tkq.2 
ENSMUST00000104156.3 Gm24326 ENSMUST00000104156.3 Gm24326 (from geneSymbol) ENSMUST00000104156.1 ENSMUST00000104156.2 uc288fpn.1 uc288fpn.2 uc288fpn.1 uc288fpn.2 
ENSMUST00000104157.3 Snord70 ENSMUST00000104157.3 small nucleolar RNA, C/D box 70 (from RefSeq NR_028554.1) ENSMUST00000104157.1 ENSMUST00000104157.2 NR_028554 uc011wlr.1 uc011wlr.2 uc011wlr.3 uc011wlr.1 uc011wlr.2 uc011wlr.3 
ENSMUST00000104159.4 Gm24671 ENSMUST00000104159.4 Gm24671 (from geneSymbol) ENSMUST00000104159.1 ENSMUST00000104159.2 ENSMUST00000104159.3 uc290zeo.1 uc290zeo.2 uc290zeo.1 uc290zeo.2 
ENSMUST00000104160.3 Gm24665 ENSMUST00000104160.3 Gm24665 (from geneSymbol) ENSMUST00000104160.1 ENSMUST00000104160.2 uc290aku.1 uc290aku.2 uc290aku.1 uc290aku.2 
ENSMUST00000104161.4 Gm24867 ENSMUST00000104161.4 Gm24867 (from geneSymbol) ENSMUST00000104161.1 ENSMUST00000104161.2 ENSMUST00000104161.3 uc289hdc.1 uc289hdc.2 uc289hdc.1 uc289hdc.2 
ENSMUST00000104166.3 Gm26286 ENSMUST00000104166.3 Gm26286 (from geneSymbol) ENSMUST00000104166.1 ENSMUST00000104166.2 uc290xnz.1 uc290xnz.2 uc290xnz.1 uc290xnz.2 
ENSMUST00000104168.3 Gm24982 ENSMUST00000104168.3 Gm24982 (from geneSymbol) ENSMUST00000104168.1 ENSMUST00000104168.2 uc291qly.1 uc291qly.2 uc291qly.1 uc291qly.2 
ENSMUST00000104169.3 Gm26289 ENSMUST00000104169.3 Gm26289 (from geneSymbol) ENSMUST00000104169.1 ENSMUST00000104169.2 uc291eka.1 uc291eka.2 uc291eka.1 uc291eka.2 
ENSMUST00000104170.3 Gm26293 ENSMUST00000104170.3 Gm26293 (from geneSymbol) ENSMUST00000104170.1 ENSMUST00000104170.2 uc287imt.1 uc287imt.2 uc287imt.1 uc287imt.2 
ENSMUST00000104171.3 Gm25308 ENSMUST00000104171.3 Gm25308 (from geneSymbol) ENSMUST00000104171.1 ENSMUST00000104171.2 uc289zlh.1 uc289zlh.2 uc289zlh.1 uc289zlh.2 
ENSMUST00000104172.3 Gm23482 ENSMUST00000104172.3 Gm23482 (from geneSymbol) ENSMUST00000104172.1 ENSMUST00000104172.2 uc288msh.1 uc288msh.2 uc288msh.1 uc288msh.2 
ENSMUST00000104173.3 Gm23481 ENSMUST00000104173.3 Gm23481 (from geneSymbol) ENSMUST00000104173.1 ENSMUST00000104173.2 uc287qzr.1 uc287qzr.2 uc287qzr.1 uc287qzr.2 
ENSMUST00000104178.3 Gm23484 ENSMUST00000104178.3 Gm23484 (from geneSymbol) ENSMUST00000104178.1 ENSMUST00000104178.2 uc290fxj.1 uc290fxj.2 uc290fxj.1 uc290fxj.2 
ENSMUST00000104179.3 Gm23483 ENSMUST00000104179.3 Gm23483 (from geneSymbol) ENSMUST00000104179.1 ENSMUST00000104179.2 uc289cfn.1 uc289cfn.2 uc289cfn.1 uc289cfn.2 
ENSMUST00000104180.3 Gm26273 ENSMUST00000104180.3 Gm26273 (from geneSymbol) ENSMUST00000104180.1 ENSMUST00000104180.2 uc287got.1 uc287got.2 uc287got.1 uc287got.2 
ENSMUST00000104181.4 Gm23485 ENSMUST00000104181.4 Gm23485 (from geneSymbol) ENSMUST00000104181.1 ENSMUST00000104181.2 ENSMUST00000104181.3 uc291fpu.1 uc291fpu.2 uc291fpu.1 uc291fpu.2 
ENSMUST00000104188.3 Gm25167 ENSMUST00000104188.3 Gm25167 (from geneSymbol) ENSMUST00000104188.1 ENSMUST00000104188.2 uc290gjc.1 uc290gjc.2 uc290gjc.1 uc290gjc.2 
ENSMUST00000104189.3 Gm25168 ENSMUST00000104189.3 Gm25168 (from geneSymbol) ENSMUST00000104189.1 ENSMUST00000104189.2 uc287gps.1 uc287gps.2 uc287gps.1 uc287gps.2 
ENSMUST00000104190.3 Gm25169 ENSMUST00000104190.3 Gm25169 (from geneSymbol) ENSMUST00000104190.1 ENSMUST00000104190.2 uc291xzy.1 uc291xzy.2 uc291xzy.1 uc291xzy.2 
ENSMUST00000104191.3 Gm25170 ENSMUST00000104191.3 Gm25170 (from geneSymbol) ENSMUST00000104191.1 ENSMUST00000104191.2 uc292qlf.1 uc292qlf.2 uc292qlf.1 uc292qlf.2 
ENSMUST00000104192.3 Gm22661 ENSMUST00000104192.3 Gm22661 (from geneSymbol) ENSMUST00000104192.1 ENSMUST00000104192.2 uc288pgm.1 uc288pgm.2 uc288pgm.1 uc288pgm.2 
ENSMUST00000104193.3 Gm22660 ENSMUST00000104193.3 Gm22660 (from geneSymbol) ENSMUST00000104193.1 ENSMUST00000104193.2 uc290qho.1 uc290qho.2 uc290qho.1 uc290qho.2 
ENSMUST00000104195.4 Gm22659 ENSMUST00000104195.4 Gm22659 (from geneSymbol) ENSMUST00000104195.1 ENSMUST00000104195.2 ENSMUST00000104195.3 uc292gzi.1 uc292gzi.2 uc292gzi.1 uc292gzi.2 
ENSMUST00000104196.3 Gm22658 ENSMUST00000104196.3 Gm22658 (from geneSymbol) ENSMUST00000104196.1 ENSMUST00000104196.2 uc292eot.1 uc292eot.2 uc292eot.1 uc292eot.2 
ENSMUST00000104197.3 Gm22657 ENSMUST00000104197.3 Gm22657 (from geneSymbol) ENSMUST00000104197.1 ENSMUST00000104197.2 uc292igy.1 uc292igy.2 uc292igy.1 uc292igy.2 
ENSMUST00000104199.3 Gm22656 ENSMUST00000104199.3 Gm22656 (from geneSymbol) ENSMUST00000104199.1 ENSMUST00000104199.2 uc290tui.1 uc290tui.2 uc290tui.1 uc290tui.2 
ENSMUST00000104203.3 Gm24336 ENSMUST00000104203.3 Gm24336 (from geneSymbol) ENSMUST00000104203.1 ENSMUST00000104203.2 uc289scx.1 uc289scx.2 uc289scx.1 uc289scx.2 
ENSMUST00000104204.2 Gm24337 ENSMUST00000104204.2 Gm24337 (from geneSymbol) ENSMUST00000104204.1 uc290lag.1 uc290lag.2 uc290lag.1 uc290lag.2 
ENSMUST00000104205.3 Gm24338 ENSMUST00000104205.3 Gm24338 (from geneSymbol) ENSMUST00000104205.1 ENSMUST00000104205.2 uc292kbk.1 uc292kbk.2 uc292kbk.1 uc292kbk.2 
ENSMUST00000104206.3 Gm24339 ENSMUST00000104206.3 Gm24339 (from geneSymbol) ENSMUST00000104206.1 ENSMUST00000104206.2 uc292eql.1 uc292eql.2 uc292eql.1 uc292eql.2 
ENSMUST00000104208.3 Gm24340 ENSMUST00000104208.3 Gm24340 (from geneSymbol) ENSMUST00000104208.1 ENSMUST00000104208.2 uc289svw.1 uc289svw.2 uc289svw.1 uc289svw.2 
ENSMUST00000104209.2 Gm24341 ENSMUST00000104209.2 Gm24341 (from geneSymbol) ENSMUST00000104209.1 uc290lre.1 uc290lre.2 uc290lre.1 uc290lre.2 
ENSMUST00000104210.3 Gm24334 ENSMUST00000104210.3 Gm24334 (from geneSymbol) ENSMUST00000104210.1 ENSMUST00000104210.2 uc288ixi.1 uc288ixi.2 uc288ixi.1 uc288ixi.2 
ENSMUST00000104211.3 Gm24335 ENSMUST00000104211.3 Gm24335 (from geneSymbol) ENSMUST00000104211.1 ENSMUST00000104211.2 uc291ytk.1 uc291ytk.2 uc291ytk.1 uc291ytk.2 
ENSMUST00000104212.3 Gm25417 ENSMUST00000104212.3 Gm25417 (from geneSymbol) ENSMUST00000104212.1 ENSMUST00000104212.2 uc292jqt.1 uc292jqt.2 uc292jqt.1 uc292jqt.2 
ENSMUST00000104214.3 Gm25418 ENSMUST00000104214.3 Gm25418 (from geneSymbol) ENSMUST00000104214.1 ENSMUST00000104214.2 uc289pwt.1 uc289pwt.2 uc289pwt.1 uc289pwt.2 
ENSMUST00000104215.3 Gm25419 ENSMUST00000104215.3 Gm25419 (from geneSymbol) ENSMUST00000104215.1 ENSMUST00000104215.2 uc290mva.1 uc290mva.2 uc290mva.1 uc290mva.2 
ENSMUST00000104216.3 Gm25420 ENSMUST00000104216.3 Gm25420 (from geneSymbol) ENSMUST00000104216.1 ENSMUST00000104216.2 uc289xig.1 uc289xig.2 uc289xig.1 uc289xig.2 
ENSMUST00000104218.3 Gm25421 ENSMUST00000104218.3 Gm25421 (from geneSymbol) ENSMUST00000104218.1 ENSMUST00000104218.2 uc292pdc.1 uc292pdc.2 uc292pdc.1 uc292pdc.2 
ENSMUST00000104219.3 Gm25422 ENSMUST00000104219.3 Gm25422 (from geneSymbol) ENSMUST00000104219.1 ENSMUST00000104219.2 uc287uqu.1 uc287uqu.2 uc287uqu.1 uc287uqu.2 
ENSMUST00000104220.3 Gm25415 ENSMUST00000104220.3 Gm25415 (from geneSymbol) ENSMUST00000104220.1 ENSMUST00000104220.2 uc288wan.1 uc288wan.2 uc288wan.1 uc288wan.2 
ENSMUST00000104221.3 Gm25416 ENSMUST00000104221.3 Gm25416 (from geneSymbol) ENSMUST00000104221.1 ENSMUST00000104221.2 uc291xhe.1 uc291xhe.2 uc291xhe.1 uc291xhe.2 
ENSMUST00000104222.3 Gm23750 ENSMUST00000104222.3 Gm23750 (from geneSymbol) ENSMUST00000104222.1 ENSMUST00000104222.2 uc290ixm.1 uc290ixm.2 uc290ixm.1 uc290ixm.2 
ENSMUST00000104223.3 Gm23749 ENSMUST00000104223.3 Gm23749 (from geneSymbol) ENSMUST00000104223.1 ENSMUST00000104223.2 uc289zcd.1 uc289zcd.2 uc289zcd.1 uc289zcd.2 
ENSMUST00000104225.3 Gm23389 ENSMUST00000104225.3 Gm23389 (from geneSymbol) ENSMUST00000104225.1 ENSMUST00000104225.2 uc287krg.1 uc287krg.2 uc287krg.1 uc287krg.2 
ENSMUST00000104227.3 Gm23748 ENSMUST00000104227.3 Gm23748 (from geneSymbol) ENSMUST00000104227.1 ENSMUST00000104227.2 uc292jef.1 uc292jef.2 uc292jef.1 uc292jef.2 
ENSMUST00000104228.3 Gm23747 ENSMUST00000104228.3 Gm23747 (from geneSymbol) ENSMUST00000104228.1 ENSMUST00000104228.2 uc288yui.1 uc288yui.2 uc288yui.1 uc288yui.2 
ENSMUST00000104229.2 Gm23746 ENSMUST00000104229.2 Gm23746 (from geneSymbol) ENSMUST00000104229.1 uc290mqn.1 uc290mqn.2 uc290mqn.1 uc290mqn.2 
ENSMUST00000104230.2 Gm23745 ENSMUST00000104230.2 Gm23745 (from geneSymbol) ENSMUST00000104230.1 uc290muf.1 uc290muf.2 uc290muf.1 uc290muf.2 
ENSMUST00000104231.4 Gm23744 ENSMUST00000104231.4 Gm23744 (from geneSymbol) DQ562105 ENSMUST00000104231.1 ENSMUST00000104231.2 ENSMUST00000104231.3 uc287mtz.1 uc287mtz.2 uc287mtz.1 uc287mtz.2 
ENSMUST00000104234.3 Gm24281 ENSMUST00000104234.3 Gm24281 (from geneSymbol) ENSMUST00000104234.1 ENSMUST00000104234.2 uc292rkn.1 uc292rkn.2 uc292rkn.1 uc292rkn.2 
ENSMUST00000104236.3 Gm24279 ENSMUST00000104236.3 Gm24279 (from geneSymbol) ENSMUST00000104236.1 ENSMUST00000104236.2 uc290xjg.1 uc290xjg.2 uc290xjg.1 uc290xjg.2 
ENSMUST00000104237.3 Gm24280 ENSMUST00000104237.3 Gm24280 (from geneSymbol) ENSMUST00000104237.1 ENSMUST00000104237.2 uc288whu.1 uc288whu.2 uc288whu.1 uc288whu.2 
ENSMUST00000104238.3 Gm26387 ENSMUST00000104238.3 Gm26387 (from geneSymbol) ENSMUST00000104238.1 ENSMUST00000104238.2 uc290xxg.1 uc290xxg.2 uc290xxg.1 uc290xxg.2 
ENSMUST00000104239.3 Gm24278 ENSMUST00000104239.3 Gm24278 (from geneSymbol) ENSMUST00000104239.1 ENSMUST00000104239.2 uc292gbg.1 uc292gbg.2 uc292gbg.1 uc292gbg.2 
ENSMUST00000104242.3 Gm22592 ENSMUST00000104242.3 Gm22592 (from geneSymbol) ENSMUST00000104242.1 ENSMUST00000104242.2 uc292nmh.1 uc292nmh.2 uc292nmh.1 uc292nmh.2 
ENSMUST00000104243.3 Gm22591 ENSMUST00000104243.3 Gm22591 (from geneSymbol) ENSMUST00000104243.1 ENSMUST00000104243.2 uc291hsa.1 uc291hsa.2 uc291hsa.1 uc291hsa.2 
ENSMUST00000104245.3 Gm22593 ENSMUST00000104245.3 Gm22593 (from geneSymbol) ENSMUST00000104245.1 ENSMUST00000104245.2 uc289nnq.1 uc289nnq.2 uc289nnq.1 uc289nnq.2 
ENSMUST00000104247.3 Gm22590 ENSMUST00000104247.3 Gm22590 (from geneSymbol) ENSMUST00000104247.1 ENSMUST00000104247.2 uc292qho.1 uc292qho.2 uc292qho.1 uc292qho.2 
ENSMUST00000104250.3 Gm22595 ENSMUST00000104250.3 Gm22595 (from geneSymbol) ENSMUST00000104250.1 ENSMUST00000104250.2 uc292kec.1 uc292kec.2 uc292kec.1 uc292kec.2 
ENSMUST00000104251.3 Gm22594 ENSMUST00000104251.3 Gm22594 (from geneSymbol) ENSMUST00000104251.1 ENSMUST00000104251.2 uc287rum.1 uc287rum.2 uc287rum.1 uc287rum.2 
ENSMUST00000104252.3 Gm23130 ENSMUST00000104252.3 Gm23130 (from geneSymbol) ENSMUST00000104252.1 ENSMUST00000104252.2 uc287qay.1 uc287qay.2 uc287qay.1 uc287qay.2 
ENSMUST00000104253.3 Gm23131 ENSMUST00000104253.3 Gm23131 (from geneSymbol) ENSMUST00000104253.1 ENSMUST00000104253.2 uc290kls.1 uc290kls.2 uc290kls.1 uc290kls.2 
ENSMUST00000104254.3 Gm23132 ENSMUST00000104254.3 Gm23132 (from geneSymbol) ENSMUST00000104254.1 ENSMUST00000104254.2 uc288aki.1 uc288aki.2 uc288aki.1 uc288aki.2 
ENSMUST00000104259.3 Gm23129 ENSMUST00000104259.3 Gm23129 (from geneSymbol) ENSMUST00000104259.1 ENSMUST00000104259.2 uc289avn.1 uc289avn.2 uc289avn.1 uc289avn.2 
ENSMUST00000104260.3 Gm23126 ENSMUST00000104260.3 Gm23126 (from geneSymbol) ENSMUST00000104260.1 ENSMUST00000104260.2 uc287hrl.1 uc287hrl.2 uc287hrl.1 uc287hrl.2 
ENSMUST00000104261.4 Gm23127 ENSMUST00000104261.4 Gm23127 (from geneSymbol) ENSMUST00000104261.1 ENSMUST00000104261.2 ENSMUST00000104261.3 uc288oqv.1 uc288oqv.2 uc288oqv.1 uc288oqv.2 
ENSMUST00000104263.3 Gm25916 ENSMUST00000104263.3 Gm25916 (from geneSymbol) ENSMUST00000104263.1 ENSMUST00000104263.2 uc289fpq.1 uc289fpq.2 uc289fpq.1 uc289fpq.2 
ENSMUST00000104265.3 Gm25915 ENSMUST00000104265.3 Gm25915 (from geneSymbol) ENSMUST00000104265.1 ENSMUST00000104265.2 uc292qwm.1 uc292qwm.2 uc292qwm.1 uc292qwm.2 
ENSMUST00000104266.3 Gm25918 ENSMUST00000104266.3 Gm25918 (from geneSymbol) ENSMUST00000104266.1 ENSMUST00000104266.2 uc290upv.1 uc290upv.2 uc290upv.1 uc290upv.2 
ENSMUST00000104267.3 Gm25917 ENSMUST00000104267.3 Gm25917 (from geneSymbol) ENSMUST00000104267.1 ENSMUST00000104267.2 uc288gmg.1 uc288gmg.2 uc288gmg.1 uc288gmg.2 
ENSMUST00000104268.3 Gm22927 ENSMUST00000104268.3 Gm22927 (from geneSymbol) ENSMUST00000104268.1 ENSMUST00000104268.2 uc287zvk.1 uc287zvk.2 uc287zvk.1 uc287zvk.2 
ENSMUST00000104269.3 Snord65 ENSMUST00000104269.3 small nucleolar RNA, C/D box 65 (from RefSeq NR_028541.1) ENSMUST00000104269.1 ENSMUST00000104269.2 NR_028541 uc011xwe.1 uc011xwe.2 uc011xwe.3 uc011xwe.1 uc011xwe.2 uc011xwe.3 
ENSMUST00000104271.3 Gm25919 ENSMUST00000104271.3 Gm25919 (from geneSymbol) ENSMUST00000104271.1 ENSMUST00000104271.2 uc290fuq.1 uc290fuq.2 uc290fuq.1 uc290fuq.2 
ENSMUST00000104272.3 Gm26419 ENSMUST00000104272.3 Gm26419 (from geneSymbol) ENSMUST00000104272.1 ENSMUST00000104272.2 uc289ebq.1 uc289ebq.2 uc289ebq.1 uc289ebq.2 
ENSMUST00000104273.3 Gm26420 ENSMUST00000104273.3 Gm26420 (from geneSymbol) ENSMUST00000104273.1 ENSMUST00000104273.2 uc290gca.1 uc290gca.2 uc290gca.1 uc290gca.2 
ENSMUST00000104274.3 Gm26417 ENSMUST00000104274.3 Gm26417 (from geneSymbol) ENSMUST00000104274.1 ENSMUST00000104274.2 uc292paj.1 uc292paj.2 uc292paj.1 uc292paj.2 
ENSMUST00000104275.3 Gm26418 ENSMUST00000104275.3 Gm26418 (from geneSymbol) ENSMUST00000104275.1 ENSMUST00000104275.2 uc287gwr.1 uc287gwr.2 uc287gwr.1 uc287gwr.2 
ENSMUST00000104277.3 Gm26423 ENSMUST00000104277.3 Gm26423 (from geneSymbol) ENSMUST00000104277.1 ENSMUST00000104277.2 uc292jmv.1 uc292jmv.2 uc292jmv.1 uc292jmv.2 
ENSMUST00000104280.3 Gm26416 ENSMUST00000104280.3 Gm26416 (from geneSymbol) ENSMUST00000104280.1 ENSMUST00000104280.2 uc288xjl.1 uc288xjl.2 uc288xjl.1 uc288xjl.2 
ENSMUST00000104281.3 Gm25922 ENSMUST00000104281.3 Gm25922 (from geneSymbol) ENSMUST00000104281.1 ENSMUST00000104281.2 uc291oln.1 uc291oln.2 uc291oln.1 uc291oln.2 
ENSMUST00000104282.3 Gm24789 ENSMUST00000104282.3 Gm24789 (from geneSymbol) BC038309 ENSMUST00000104282.1 ENSMUST00000104282.2 uc288xuc.1 uc288xuc.2 uc288xuc.1 uc288xuc.2 
ENSMUST00000104283.4 Gm24788 ENSMUST00000104283.4 Gm24788 (from geneSymbol) ENSMUST00000104283.1 ENSMUST00000104283.2 ENSMUST00000104283.3 uc287iup.1 uc287iup.2 uc287iup.1 uc287iup.2 
ENSMUST00000104284.3 Gm24791 ENSMUST00000104284.3 Gm24791 (from geneSymbol) ENSMUST00000104284.1 ENSMUST00000104284.2 uc287lhl.1 uc287lhl.2 uc287lhl.1 uc287lhl.2 
ENSMUST00000104285.3 Gm24790 ENSMUST00000104285.3 Gm24790 (from geneSymbol) ENSMUST00000104285.1 ENSMUST00000104285.2 uc288kko.1 uc288kko.2 uc288kko.1 uc288kko.2 
ENSMUST00000104286.3 Gm24792 ENSMUST00000104286.3 Gm24792 (from geneSymbol) ENSMUST00000104286.1 ENSMUST00000104286.2 uc290wsb.1 uc290wsb.2 uc290wsb.1 uc290wsb.2 
ENSMUST00000104288.3 Gm24794 ENSMUST00000104288.3 Gm24794 (from geneSymbol) ENSMUST00000104288.1 ENSMUST00000104288.2 uc289gzr.1 uc289gzr.2 uc289gzr.1 uc289gzr.2 
ENSMUST00000104289.3 Gm24793 ENSMUST00000104289.3 Gm24793 (from geneSymbol) ENSMUST00000104289.1 ENSMUST00000104289.2 uc292dgr.1 uc292dgr.2 uc292dgr.1 uc292dgr.2 
ENSMUST00000104293.3 Gm25272 ENSMUST00000104293.3 Gm25272 (from geneSymbol) ENSMUST00000104293.1 ENSMUST00000104293.2 uc288wra.1 uc288wra.2 uc288wra.1 uc288wra.2 
ENSMUST00000104296.3 Gm25274 ENSMUST00000104296.3 Gm25274 (from geneSymbol) ENSMUST00000104296.1 ENSMUST00000104296.2 uc288koe.1 uc288koe.2 uc288koe.1 uc288koe.2 
ENSMUST00000104297.3 Gm25275 ENSMUST00000104297.3 Gm25275 (from geneSymbol) ENSMUST00000104297.1 ENSMUST00000104297.2 uc292ahs.1 uc292ahs.2 uc292ahs.1 uc292ahs.2 
ENSMUST00000104300.3 Gm25276 ENSMUST00000104300.3 Gm25276 (from geneSymbol) ENSMUST00000104300.1 ENSMUST00000104300.2 uc289cnh.1 uc289cnh.2 uc289cnh.1 uc289cnh.2 
ENSMUST00000104304.4 Gm23596 ENSMUST00000104304.4 Gm23596 (from geneSymbol) ENSMUST00000104304.1 ENSMUST00000104304.2 ENSMUST00000104304.3 uc288uku.1 uc288uku.2 uc288uku.1 uc288uku.2 
ENSMUST00000104305.3 Snord91a ENSMUST00000104305.3 small nucleolar RNA, C/D box 91A (from RefSeq NR_028562.1) ENSMUST00000104305.1 ENSMUST00000104305.2 NR_028562 uc011xzc.1 uc011xzc.2 uc011xzc.3 uc011xzc.1 uc011xzc.2 uc011xzc.3 
ENSMUST00000104306.3 Gm23595 ENSMUST00000104306.3 Gm23595 (from geneSymbol) ENSMUST00000104306.1 ENSMUST00000104306.2 uc292ksr.1 uc292ksr.2 uc292ksr.1 uc292ksr.2 
ENSMUST00000104307.3 Gm23594 ENSMUST00000104307.3 Gm23594 (from geneSymbol) ENSMUST00000104307.1 ENSMUST00000104307.2 uc292jzg.1 uc292jzg.2 uc292jzg.1 uc292jzg.2 
ENSMUST00000104309.3 Gm23593 ENSMUST00000104309.3 Gm23593 (from geneSymbol) ENSMUST00000104309.1 ENSMUST00000104309.2 uc288uuw.1 uc288uuw.2 uc288uuw.1 uc288uuw.2 
ENSMUST00000104313.3 Gm24230 ENSMUST00000104313.3 Gm24230 (from geneSymbol) ENSMUST00000104313.1 ENSMUST00000104313.2 uc291equ.1 uc291equ.2 uc291equ.1 uc291equ.2 
ENSMUST00000104314.3 Gm24232 ENSMUST00000104314.3 Gm24232 (from geneSymbol) ENSMUST00000104314.1 ENSMUST00000104314.2 uc288yno.1 uc288yno.2 uc288yno.1 uc288yno.2 
ENSMUST00000104315.4 Gm24231 ENSMUST00000104315.4 Gm24231 (from geneSymbol) ENSMUST00000104315.1 ENSMUST00000104315.2 ENSMUST00000104315.3 uc291yml.1 uc291yml.2 uc291yml.1 uc291yml.2 
ENSMUST00000104316.3 Gm24234 ENSMUST00000104316.3 Gm24234 (from geneSymbol) ENSMUST00000104316.1 ENSMUST00000104316.2 uc290neu.1 uc290neu.2 uc290neu.1 uc290neu.2 
ENSMUST00000104317.3 Gm24233 ENSMUST00000104317.3 Gm24233 (from geneSymbol) ENSMUST00000104317.1 ENSMUST00000104317.2 uc288gpf.1 uc288gpf.2 uc288gpf.1 uc288gpf.2 
ENSMUST00000104318.3 Scarna9 ENSMUST00000104318.3 Scarna9 (from geneSymbol) AJ242789 ENSMUST00000104318.1 ENSMUST00000104318.2 uc012goq.1 uc012goq.2 uc012goq.3 uc012goq.1 uc012goq.2 uc012goq.3 
ENSMUST00000104319.3 Gm24235 ENSMUST00000104319.3 Gm24235 (from geneSymbol) ENSMUST00000104319.1 ENSMUST00000104319.2 uc290vpg.1 uc290vpg.2 uc290vpg.1 uc290vpg.2 
ENSMUST00000104323.3 Gm25875 ENSMUST00000104323.3 Gm25875 (from geneSymbol) ENSMUST00000104323.1 ENSMUST00000104323.2 uc288yga.1 uc288yga.2 uc288yga.1 uc288yga.2 
ENSMUST00000104326.3 Gm25877 ENSMUST00000104326.3 Gm25877 (from geneSymbol) ENSMUST00000104326.1 ENSMUST00000104326.2 uc290oey.1 uc290oey.2 uc290oey.1 uc290oey.2 
ENSMUST00000104327.3 Gm25878 ENSMUST00000104327.3 Gm25878 (from geneSymbol) ENSMUST00000104327.1 ENSMUST00000104327.2 uc290crz.1 uc290crz.2 uc290crz.1 uc290crz.2 
ENSMUST00000104330.3 Gm25879 ENSMUST00000104330.3 Gm25879 (from geneSymbol) ENSMUST00000104330.1 ENSMUST00000104330.2 uc290dpx.1 uc290dpx.2 uc290dpx.1 uc290dpx.2 
ENSMUST00000104331.3 Gm25880 ENSMUST00000104331.3 Gm25880 (from geneSymbol) ENSMUST00000104331.1 ENSMUST00000104331.2 uc290sga.1 uc290sga.2 uc290sga.1 uc290sga.2 
ENSMUST00000104332.4 Gm25526 ENSMUST00000104332.4 Gm25526 (from geneSymbol) ENSMUST00000104332.1 ENSMUST00000104332.2 ENSMUST00000104332.3 uc287qrx.1 uc287qrx.2 uc287qrx.1 uc287qrx.2 
ENSMUST00000104333.2 Gm25378 ENSMUST00000104333.2 Gm25378 (from geneSymbol) ENSMUST00000104333.1 uc290lnv.1 uc290lnv.2 uc290lnv.1 uc290lnv.2 
ENSMUST00000104334.3 Gm25377 ENSMUST00000104334.3 Gm25377 (from geneSymbol) ENSMUST00000104334.1 ENSMUST00000104334.2 uc290vcd.1 uc290vcd.2 uc290vcd.1 uc290vcd.2 
ENSMUST00000104338.3 Gm25379 ENSMUST00000104338.3 Gm25379 (from geneSymbol) ENSMUST00000104338.1 ENSMUST00000104338.2 uc292abd.1 uc292abd.2 uc292abd.1 uc292abd.2 
ENSMUST00000104339.3 Gm25506 ENSMUST00000104339.3 Gm25506 (from geneSymbol) ENSMUST00000104339.1 ENSMUST00000104339.2 LF197097 uc292brb.1 uc292brb.2 uc292brb.1 uc292brb.2 
ENSMUST00000104340.3 Gm25376 ENSMUST00000104340.3 Gm25376 (from geneSymbol) ENSMUST00000104340.1 ENSMUST00000104340.2 uc287upo.1 uc287upo.2 uc287upo.1 uc287upo.2 
ENSMUST00000104347.4 Gm22543 ENSMUST00000104347.4 Gm22543 (from geneSymbol) ENSMUST00000104347.1 ENSMUST00000104347.2 ENSMUST00000104347.3 uc289erm.1 uc289erm.2 uc289erm.1 uc289erm.2 
ENSMUST00000104349.3 Gm22544 ENSMUST00000104349.3 Gm22544 (from geneSymbol) ENSMUST00000104349.1 ENSMUST00000104349.2 uc292bdh.1 uc292bdh.2 uc292bdh.1 uc292bdh.2 
ENSMUST00000104350.3 Gm22545 ENSMUST00000104350.3 Gm22545 (from geneSymbol) ENSMUST00000104350.1 ENSMUST00000104350.2 uc292een.1 uc292een.2 uc292een.1 uc292een.2 
ENSMUST00000104351.3 Gm22546 ENSMUST00000104351.3 Gm22546 (from geneSymbol) ENSMUST00000104351.1 ENSMUST00000104351.2 uc287poa.1 uc287poa.2 uc287poa.1 uc287poa.2 
ENSMUST00000104352.4 Gm24079 ENSMUST00000104352.4 Gm24079 (from geneSymbol) ENSMUST00000104352.1 ENSMUST00000104352.2 ENSMUST00000104352.3 uc290vrz.1 uc290vrz.2 uc290vrz.1 uc290vrz.2 
ENSMUST00000104353.3 Gm22021 ENSMUST00000104353.3 Gm22021 (from geneSymbol) ENSMUST00000104353.1 ENSMUST00000104353.2 uc288whq.1 uc288whq.2 uc288whq.1 uc288whq.2 
ENSMUST00000104354.3 Gm22023 ENSMUST00000104354.3 Gm22023 (from geneSymbol) ENSMUST00000104354.1 ENSMUST00000104354.2 LF202320 uc292rrd.1 uc292rrd.2 uc292rrd.1 uc292rrd.2 
ENSMUST00000104355.3 Gm22022 ENSMUST00000104355.3 Gm22022 (from geneSymbol) ENSMUST00000104355.1 ENSMUST00000104355.2 uc287xjs.1 uc287xjs.2 uc287xjs.1 uc287xjs.2 
ENSMUST00000104357.3 Gm22018 ENSMUST00000104357.3 Gm22018 (from geneSymbol) ENSMUST00000104357.1 ENSMUST00000104357.2 uc292ail.1 uc292ail.2 uc292ail.1 uc292ail.2 
ENSMUST00000104358.3 Gm22020 ENSMUST00000104358.3 Gm22020 (from geneSymbol) ENSMUST00000104358.1 ENSMUST00000104358.2 uc289wlh.1 uc289wlh.2 uc289wlh.1 uc289wlh.2 
ENSMUST00000104359.3 Gm22019 ENSMUST00000104359.3 Gm22019 (from geneSymbol) ENSMUST00000104359.1 ENSMUST00000104359.2 uc291wzt.1 uc291wzt.2 uc291wzt.1 uc291wzt.2 
ENSMUST00000104361.3 Snord71 ENSMUST00000104361.3 small nucleolar RNA, C/D box 71 (from RefSeq NR_028532.1) ENSMUST00000104361.1 ENSMUST00000104361.2 NR_028532 uc012gkm.1 uc012gkm.2 uc012gkm.3 uc012gkm.1 uc012gkm.2 uc012gkm.3 
ENSMUST00000104364.2 Gm23709 ENSMUST00000104364.2 Gm23709 (from geneSymbol) ENSMUST00000104364.1 uc290mdi.1 uc290mdi.2 uc290mdi.1 uc290mdi.2 
ENSMUST00000104365.3 Gm23176 ENSMUST00000104365.3 Gm23176 (from geneSymbol) ENSMUST00000104365.1 ENSMUST00000104365.2 uc292jkf.1 uc292jkf.2 uc292jkf.1 uc292jkf.2 
ENSMUST00000104366.3 Gm23707 ENSMUST00000104366.3 Gm23707 (from geneSymbol) ENSMUST00000104366.1 ENSMUST00000104366.2 uc292jmo.1 uc292jmo.2 uc292jmo.1 uc292jmo.2 
ENSMUST00000104367.3 Gm23708 ENSMUST00000104367.3 Gm23708 (from geneSymbol) ENSMUST00000104367.1 ENSMUST00000104367.2 uc290vrp.1 uc290vrp.2 uc290vrp.1 uc290vrp.2 
ENSMUST00000104369.3 Gm23706 ENSMUST00000104369.3 Gm23706 (from geneSymbol) ENSMUST00000104369.1 ENSMUST00000104369.2 uc289cgz.1 uc289cgz.2 uc289cgz.1 uc289cgz.2 
ENSMUST00000104370.3 Gm23705 ENSMUST00000104370.3 Gm23705 (from geneSymbol) ENSMUST00000104370.1 ENSMUST00000104370.2 uc292nyn.1 uc292nyn.2 uc292nyn.1 uc292nyn.2 
ENSMUST00000104371.3 Gm23175 ENSMUST00000104371.3 Gm23175 (from geneSymbol) ENSMUST00000104371.1 ENSMUST00000104371.2 uc290emf.1 uc290emf.2 uc290emf.1 uc290emf.2 
ENSMUST00000104373.2 Gm24607 ENSMUST00000104373.2 Gm24607 (from geneSymbol) ENSMUST00000104373.1 uc290llj.1 uc290llj.2 uc290llj.1 uc290llj.2 
ENSMUST00000104374.3 Gm23203 ENSMUST00000104374.3 Gm23203 (from geneSymbol) ENSMUST00000104374.1 ENSMUST00000104374.2 uc289mgv.1 uc289mgv.2 uc289mgv.1 uc289mgv.2 
ENSMUST00000104375.3 Snora68 ENSMUST00000104375.3 small nucleolar RNA, H/ACA box 68 (from RefSeq NR_002901.1) ENSMUST00000104375.1 ENSMUST00000104375.2 NR_002901 uc292atk.1 uc292atk.2 uc292atk.1 uc292atk.2 
ENSMUST00000104376.3 Gm23202 ENSMUST00000104376.3 Gm23202 (from geneSymbol) ENSMUST00000104376.1 ENSMUST00000104376.2 uc291bur.1 uc291bur.2 uc291bur.1 uc291bur.2 
ENSMUST00000104377.3 Gm23201 ENSMUST00000104377.3 Gm23201 (from geneSymbol) ENSMUST00000104377.1 ENSMUST00000104377.2 FM991914 uc290csb.1 uc290csb.2 uc290csb.1 uc290csb.2 
ENSMUST00000104379.3 Gm23200 ENSMUST00000104379.3 Gm23200 (from geneSymbol) ENSMUST00000104379.1 ENSMUST00000104379.2 uc288yaq.1 uc288yaq.2 uc288yaq.1 uc288yaq.2 
ENSMUST00000104381.3 Gm24608 ENSMUST00000104381.3 Gm24608 (from geneSymbol) ENSMUST00000104381.1 ENSMUST00000104381.2 LF194016 uc290gzj.1 uc290gzj.2 uc290gzj.1 uc290gzj.2 
ENSMUST00000104384.3 Gm24886 ENSMUST00000104384.3 Gm24886 (from geneSymbol) ENSMUST00000104384.1 ENSMUST00000104384.2 uc289tmr.1 uc289tmr.2 uc289tmr.1 uc289tmr.2 
ENSMUST00000104386.3 Gm24887 ENSMUST00000104386.3 Gm24887 (from geneSymbol) ENSMUST00000104386.1 ENSMUST00000104386.2 uc288aqy.1 uc288aqy.2 uc288aqy.1 uc288aqy.2 
ENSMUST00000104387.3 Gm24888 ENSMUST00000104387.3 Gm24888 (from geneSymbol) ENSMUST00000104387.1 ENSMUST00000104387.2 uc291uiy.1 uc291uiy.2 uc291uiy.1 uc291uiy.2 
ENSMUST00000104388.3 Gm24889 ENSMUST00000104388.3 Gm24889 (from geneSymbol) ENSMUST00000104388.1 ENSMUST00000104388.2 uc287qnp.1 uc287qnp.2 uc287qnp.1 uc287qnp.2 
ENSMUST00000104389.4 Gm24890 ENSMUST00000104389.4 Gm24890 (from geneSymbol) ENSMUST00000104389.1 ENSMUST00000104389.2 ENSMUST00000104389.3 uc288vmn.1 uc288vmn.2 uc288vmn.1 uc288vmn.2 
ENSMUST00000104390.3 Gm25631 ENSMUST00000104390.3 Gm25631 (from geneSymbol) ENSMUST00000104390.1 ENSMUST00000104390.2 uc288pta.1 uc288pta.2 uc288pta.1 uc288pta.2 
ENSMUST00000104391.3 Gm24891 ENSMUST00000104391.3 Gm24891 (from geneSymbol) ENSMUST00000104391.1 ENSMUST00000104391.2 uc289fut.1 uc289fut.2 uc289fut.1 uc289fut.2 
ENSMUST00000104393.3 Gm24373 ENSMUST00000104393.3 Gm24373 (from geneSymbol) ENSMUST00000104393.1 ENSMUST00000104393.2 uc290kvc.1 uc290kvc.2 uc290kvc.1 uc290kvc.2 
ENSMUST00000104394.3 Gm24374 ENSMUST00000104394.3 Gm24374 (from geneSymbol) ENSMUST00000104394.1 ENSMUST00000104394.2 uc287pks.1 uc287pks.2 uc287pks.1 uc287pks.2 
ENSMUST00000104397.3 Gm24375 ENSMUST00000104397.3 Gm24375 (from geneSymbol) ENSMUST00000104397.1 ENSMUST00000104397.2 uc291zyn.1 uc291zyn.2 uc291zyn.1 uc291zyn.2 
ENSMUST00000104398.3 Gm24377 ENSMUST00000104398.3 Gm24377 (from geneSymbol) ENSMUST00000104398.1 ENSMUST00000104398.2 uc288gpy.1 uc288gpy.2 uc288gpy.1 uc288gpy.2 
ENSMUST00000104399.2 Gm24376 ENSMUST00000104399.2 Gm24376 (from geneSymbol) ENSMUST00000104399.1 uc290mjn.1 uc290mjn.2 uc290mjn.1 uc290mjn.2 
ENSMUST00000104400.3 Gm54376 ENSMUST00000104400.3 Gm54376 (from geneSymbol) ENSMUST00000104400.1 ENSMUST00000104400.2 uc289ohg.1 uc289ohg.2 uc289ohg.1 uc289ohg.2 
ENSMUST00000104402.3 Gm26015 ENSMUST00000104402.3 Gm26015 (from geneSymbol) ENSMUST00000104402.1 ENSMUST00000104402.2 uc288gty.1 uc288gty.2 uc288gty.1 uc288gty.2 
ENSMUST00000104403.3 Gm26016 ENSMUST00000104403.3 Gm26016 (from geneSymbol) ENSMUST00000104403.1 ENSMUST00000104403.2 uc287qyr.1 uc287qyr.2 uc287qyr.1 uc287qyr.2 
ENSMUST00000104404.3 Gm26013 ENSMUST00000104404.3 Gm26013 (from geneSymbol) ENSMUST00000104404.1 ENSMUST00000104404.2 uc291cdg.1 uc291cdg.2 uc291cdg.1 uc291cdg.2 
ENSMUST00000104405.3 Gm26014 ENSMUST00000104405.3 Gm26014 (from geneSymbol) ENSMUST00000104405.1 ENSMUST00000104405.2 uc289psf.1 uc289psf.2 uc289psf.1 uc289psf.2 
ENSMUST00000104406.4 Gm26018 ENSMUST00000104406.4 Gm26018 (from geneSymbol) ENSMUST00000104406.1 ENSMUST00000104406.2 ENSMUST00000104406.3 uc288ojl.1 uc288ojl.2 uc288ojl.1 uc288ojl.2 
ENSMUST00000104407.3 Gm26019 ENSMUST00000104407.3 Gm26019 (from geneSymbol) ENSMUST00000104407.1 ENSMUST00000104407.2 uc289ffd.1 uc289ffd.2 uc289ffd.1 uc289ffd.2 
ENSMUST00000104409.4 Gm26017 ENSMUST00000104409.4 Gm26017 (from geneSymbol) ENSMUST00000104409.1 ENSMUST00000104409.2 ENSMUST00000104409.3 uc290npl.1 uc290npl.2 uc290npl.1 uc290npl.2 
ENSMUST00000104410.4 Gm26011 ENSMUST00000104410.4 Gm26011 (from geneSymbol) ENSMUST00000104410.1 ENSMUST00000104410.2 ENSMUST00000104410.3 uc291hhw.1 uc291hhw.2 uc291hhw.1 uc291hhw.2 
ENSMUST00000104411.3 Gm26012 ENSMUST00000104411.3 Gm26012 (from geneSymbol) ENSMUST00000104411.1 ENSMUST00000104411.2 uc289puk.1 uc289puk.2 uc289puk.1 uc289puk.2 
ENSMUST00000104413.3 Gm22674 ENSMUST00000104413.3 Gm22674 (from geneSymbol) ENSMUST00000104413.1 ENSMUST00000104413.2 uc288lzj.1 uc288lzj.2 uc288lzj.1 uc288lzj.2 
ENSMUST00000104414.3 Gm22672 ENSMUST00000104414.3 Gm22672 (from geneSymbol) ENSMUST00000104414.1 ENSMUST00000104414.2 uc289dvp.1 uc289dvp.2 uc289dvp.1 uc289dvp.2 
ENSMUST00000104415.3 Gm22673 ENSMUST00000104415.3 Gm22673 (from geneSymbol) ENSMUST00000104415.1 ENSMUST00000104415.2 uc288gpz.1 uc288gpz.2 uc288gpz.1 uc288gpz.2 
ENSMUST00000104416.3 Snord1b ENSMUST00000104416.3 small nucleolar RNA, C/D box 1B (from RefSeq NR_028567.1) ENSMUST00000104416.1 ENSMUST00000104416.2 NR_028567 uc288duf.1 uc288duf.2 uc288duf.1 uc288duf.2 
ENSMUST00000104419.3 Gm25803 ENSMUST00000104419.3 Gm25803 (from geneSymbol) ENSMUST00000104419.1 ENSMUST00000104419.2 uc290nlb.1 uc290nlb.2 uc290nlb.1 uc290nlb.2 
ENSMUST00000104420.3 Gm22671 ENSMUST00000104420.3 Gm22671 (from geneSymbol) ENSMUST00000104420.1 ENSMUST00000104420.2 uc287ngx.1 uc287ngx.2 uc287ngx.1 uc287ngx.2 
ENSMUST00000104421.3 Gm25795 ENSMUST00000104421.3 Gm25795 (from geneSymbol) ENSMUST00000104421.1 ENSMUST00000104421.2 uc292rkk.1 uc292rkk.2 uc292rkk.1 uc292rkk.2 
ENSMUST00000104423.3 Gm23946 ENSMUST00000104423.3 Gm23946 (from geneSymbol) ENSMUST00000104423.1 ENSMUST00000104423.2 uc288sfu.1 uc288sfu.2 uc288sfu.1 uc288sfu.2 
ENSMUST00000104424.3 Gm25498 ENSMUST00000104424.3 Gm25498 (from geneSymbol) ENSMUST00000104424.1 ENSMUST00000104424.2 uc288shn.1 uc288shn.2 uc288shn.1 uc288shn.2 
ENSMUST00000104425.3 Gm25497 ENSMUST00000104425.3 Gm25497 (from geneSymbol) ENSMUST00000104425.1 ENSMUST00000104425.2 uc288gcl.1 uc288gcl.2 uc288gcl.1 uc288gcl.2 
ENSMUST00000104427.3 Gm25499 ENSMUST00000104427.3 Gm25499 (from geneSymbol) ENSMUST00000104427.1 ENSMUST00000104427.2 uc291qni.1 uc291qni.2 uc291qni.1 uc291qni.2 
ENSMUST00000104428.3 Gm25502 ENSMUST00000104428.3 Gm25502 (from geneSymbol) ENSMUST00000104428.1 ENSMUST00000104428.2 uc287iky.1 uc287iky.2 uc287iky.1 uc287iky.2 
ENSMUST00000104429.3 Gm25501 ENSMUST00000104429.3 Gm25501 (from geneSymbol) ENSMUST00000104429.1 ENSMUST00000104429.2 uc290jmm.1 uc290jmm.2 uc290jmm.1 uc290jmm.2 
ENSMUST00000104430.3 Gm25496 ENSMUST00000104430.3 Gm25496 (from geneSymbol) ENSMUST00000104430.1 ENSMUST00000104430.2 uc288krg.1 uc288krg.2 uc288krg.1 uc288krg.2 
ENSMUST00000104431.3 Gm25495 ENSMUST00000104431.3 Gm25495 (from geneSymbol) ENSMUST00000104431.1 ENSMUST00000104431.2 uc288war.1 uc288war.2 uc288war.1 uc288war.2 
ENSMUST00000104436.3 Gm23834 ENSMUST00000104436.3 Gm23834 (from geneSymbol) ENSMUST00000104436.1 ENSMUST00000104436.2 uc290qzr.1 uc290qzr.2 uc290qzr.1 uc290qzr.2 
ENSMUST00000104437.3 Snord4a ENSMUST00000104437.3 small nucleolar RNA, C/D box 4A (from RefSeq NR_030702.1) ENSMUST00000104437.1 ENSMUST00000104437.2 NR_030702 uc011yag.1 uc011yag.2 uc011yag.3 uc011yag.1 uc011yag.2 uc011yag.3 
ENSMUST00000104439.3 Gm23835 ENSMUST00000104439.3 Gm23835 (from geneSymbol) ENSMUST00000104439.1 ENSMUST00000104439.2 uc288ygj.1 uc288ygj.2 uc288ygj.1 uc288ygj.2 
ENSMUST00000104440.3 Gm23768 ENSMUST00000104440.3 Gm23768 (from geneSymbol) ENSMUST00000104440.1 ENSMUST00000104440.2 uc292qln.1 uc292qln.2 uc292qln.1 uc292qln.2 
ENSMUST00000104441.3 Gm23769 ENSMUST00000104441.3 Gm23769 (from geneSymbol) ENSMUST00000104441.1 ENSMUST00000104441.2 uc289mgu.1 uc289mgu.2 uc289mgu.1 uc289mgu.2 
ENSMUST00000104442.3 Gm22149 ENSMUST00000104442.3 Gm22149 (from geneSymbol) ENSMUST00000104442.1 ENSMUST00000104442.2 uc288hqp.1 uc288hqp.2 uc288hqp.1 uc288hqp.2 
ENSMUST00000104444.4 Gm23266 ENSMUST00000104444.4 Gm23266 (from geneSymbol) ENSMUST00000104444.1 ENSMUST00000104444.2 ENSMUST00000104444.3 uc287zus.1 uc287zus.2 uc287zus.1 uc287zus.2 
ENSMUST00000104445.3 Gm22148 ENSMUST00000104445.3 Gm22148 (from geneSymbol) ENSMUST00000104445.1 ENSMUST00000104445.2 uc292cqm.1 uc292cqm.2 uc292cqm.1 uc292cqm.2 
ENSMUST00000104447.2 Gm22150 ENSMUST00000104447.2 Gm22150 (from geneSymbol) ENSMUST00000104447.1 uc290mvh.1 uc290mvh.2 uc290mvh.1 uc290mvh.2 
ENSMUST00000104449.3 Gm22771 ENSMUST00000104449.3 Gm22771 (from geneSymbol) ENSMUST00000104449.1 ENSMUST00000104449.2 LF198670 uc288adg.1 uc288adg.2 uc288adg.1 uc288adg.2 
ENSMUST00000104451.3 Gm22772 ENSMUST00000104451.3 Gm22772 (from geneSymbol) ENSMUST00000104451.1 ENSMUST00000104451.2 uc288aja.1 uc288aja.2 uc288aja.1 uc288aja.2 
ENSMUST00000104453.3 Gm24987 ENSMUST00000104453.3 Gm24987 (from geneSymbol) ENSMUST00000104453.1 ENSMUST00000104453.2 uc289pwh.1 uc289pwh.2 uc289pwh.1 uc289pwh.2 
ENSMUST00000104454.3 Gm24984 ENSMUST00000104454.3 Gm24984 (from geneSymbol) ENSMUST00000104454.1 ENSMUST00000104454.2 uc287scb.1 uc287scb.2 uc287scb.1 uc287scb.2 
ENSMUST00000104455.3 Gm24985 ENSMUST00000104455.3 Gm24985 (from geneSymbol) ENSMUST00000104455.1 ENSMUST00000104455.2 uc291cor.1 uc291cor.2 uc291cor.1 uc291cor.2 
ENSMUST00000104456.3 Gm26288 ENSMUST00000104456.3 Gm26288 (from geneSymbol) ENSMUST00000104456.1 ENSMUST00000104456.2 uc291urd.1 uc291urd.2 uc291urd.1 uc291urd.2 
ENSMUST00000104457.3 Gm24983 ENSMUST00000104457.3 Gm24983 (from geneSymbol) ENSMUST00000104457.1 ENSMUST00000104457.2 uc291qpm.1 uc291qpm.2 uc291qpm.1 uc291qpm.2 
ENSMUST00000104459.3 Gm24981 ENSMUST00000104459.3 Gm24981 (from geneSymbol) ENSMUST00000104459.1 ENSMUST00000104459.2 uc288via.1 uc288via.2 uc288via.1 uc288via.2 
ENSMUST00000104460.3 Gm24988 ENSMUST00000104460.3 Gm24988 (from geneSymbol) ENSMUST00000104460.1 ENSMUST00000104460.2 uc287nar.1 uc287nar.2 uc287nar.1 uc287nar.2 
ENSMUST00000104461.3 Gm24989 ENSMUST00000104461.3 Gm24989 (from geneSymbol) ENSMUST00000104461.1 ENSMUST00000104461.2 uc288ajj.1 uc288ajj.2 uc288ajj.1 uc288ajj.2 
ENSMUST00000104462.3 Gm23320 ENSMUST00000104462.3 Gm23320 (from geneSymbol) ENSMUST00000104462.1 ENSMUST00000104462.2 uc292pdl.1 uc292pdl.2 uc292pdl.1 uc292pdl.2 
ENSMUST00000104464.3 Gm23322 ENSMUST00000104464.3 Gm23322 (from geneSymbol) ENSMUST00000104464.1 ENSMUST00000104464.2 uc292qcw.1 uc292qcw.2 uc292qcw.1 uc292qcw.2 
ENSMUST00000104465.3 Gm23321 ENSMUST00000104465.3 Gm23321 (from geneSymbol) ENSMUST00000104465.1 ENSMUST00000104465.2 uc291uwv.1 uc291uwv.2 uc291uwv.1 uc291uwv.2 
ENSMUST00000104467.3 Gm23319 ENSMUST00000104467.3 Gm23319 (from geneSymbol) ENSMUST00000104467.1 ENSMUST00000104467.2 uc288ore.1 uc288ore.2 uc288ore.1 uc288ore.2 
ENSMUST00000104471.3 Gm23323 ENSMUST00000104471.3 Gm23323 (from geneSymbol) ENSMUST00000104471.1 ENSMUST00000104471.2 uc292mpp.1 uc292mpp.2 uc292mpp.1 uc292mpp.2 
ENSMUST00000104472.3 Gm24257 ENSMUST00000104472.3 Gm24257 (from geneSymbol) ENSMUST00000104472.1 ENSMUST00000104472.2 uc292ilv.1 uc292ilv.2 uc292ilv.1 uc292ilv.2 
ENSMUST00000104475.2 Gm26144 ENSMUST00000104475.2 Gm26144 (from geneSymbol) ENSMUST00000104475.1 uc290mvp.1 uc290mvp.2 uc290mvp.1 uc290mvp.2 
ENSMUST00000104476.3 Gm26145 ENSMUST00000104476.3 Gm26145 (from geneSymbol) ENSMUST00000104476.1 ENSMUST00000104476.2 uc287hap.1 uc287hap.2 uc287hap.1 uc287hap.2 
ENSMUST00000104478.4 Gm26146 ENSMUST00000104478.4 Gm26146 (from geneSymbol) ENSMUST00000104478.1 ENSMUST00000104478.2 ENSMUST00000104478.3 uc292jgo.1 uc292jgo.2 uc292jgo.1 uc292jgo.2 
ENSMUST00000104479.3 Gm26147 ENSMUST00000104479.3 Gm26147 (from geneSymbol) ENSMUST00000104479.1 ENSMUST00000104479.2 uc291uwk.1 uc291uwk.2 uc291uwk.1 uc291uwk.2 
ENSMUST00000104480.3 Gm26143 ENSMUST00000104480.3 Gm26143 (from geneSymbol) ENSMUST00000104480.1 ENSMUST00000104480.2 uc291xif.1 uc291xif.2 uc291xif.1 uc291xif.2 
ENSMUST00000104481.3 Gm24255 ENSMUST00000104481.3 Gm24255 (from geneSymbol) ENSMUST00000104481.1 ENSMUST00000104481.2 uc287xbc.1 uc287xbc.2 uc287xbc.1 uc287xbc.2 
ENSMUST00000104483.3 Gm24473 ENSMUST00000104483.3 Gm24473 (from geneSymbol) ENSMUST00000104483.1 ENSMUST00000104483.2 uc290ckr.1 uc290ckr.2 uc290ckr.1 uc290ckr.2 
ENSMUST00000104484.3 Gm24472 ENSMUST00000104484.3 Gm24472 (from geneSymbol) ENSMUST00000104484.1 ENSMUST00000104484.2 uc290giq.1 uc290giq.2 uc290giq.1 uc290giq.2 
ENSMUST00000104485.3 Gm24471 ENSMUST00000104485.3 Gm24471 (from geneSymbol) ENSMUST00000104485.1 ENSMUST00000104485.2 uc288pmg.1 uc288pmg.2 uc288pmg.1 uc288pmg.2 
ENSMUST00000104486.3 Gm24470 ENSMUST00000104486.3 Gm24470 (from geneSymbol) ENSMUST00000104486.1 ENSMUST00000104486.2 uc292pgk.1 uc292pgk.2 uc292pgk.1 uc292pgk.2 
ENSMUST00000104487.3 Gm24469 ENSMUST00000104487.3 Gm24469 (from geneSymbol) ENSMUST00000104487.1 ENSMUST00000104487.2 uc291ynl.1 uc291ynl.2 uc291ynl.1 uc291ynl.2 
ENSMUST00000104489.3 Gm24468 ENSMUST00000104489.3 Gm24468 (from geneSymbol) ENSMUST00000104489.1 ENSMUST00000104489.2 uc290obo.1 uc290obo.2 uc290obo.1 uc290obo.2 
ENSMUST00000104490.3 Gm24318 ENSMUST00000104490.3 Gm24318 (from geneSymbol) ENSMUST00000104490.1 ENSMUST00000104490.2 uc289yrw.1 uc289yrw.2 uc289yrw.1 uc289yrw.2 
ENSMUST00000104492.3 Gm22495 ENSMUST00000104492.3 Gm22495 (from geneSymbol) ENSMUST00000104492.1 ENSMUST00000104492.2 uc289oic.1 uc289oic.2 uc289oic.1 uc289oic.2 
ENSMUST00000104493.3 Gm22496 ENSMUST00000104493.3 predicted gene, 22496 (from RefSeq NR_146600.1) ENSMUST00000104493.1 ENSMUST00000104493.2 NR_146600 uc291qnk.1 uc291qnk.2 uc291qnk.1 uc291qnk.2 
ENSMUST00000104494.3 Gm22493 ENSMUST00000104494.3 Gm22493 (from geneSymbol) ENSMUST00000104494.1 ENSMUST00000104494.2 uc291ese.1 uc291ese.2 uc291ese.1 uc291ese.2 
ENSMUST00000104495.3 Gm22494 ENSMUST00000104495.3 Gm22494 (from geneSymbol) ENSMUST00000104495.1 ENSMUST00000104495.2 uc291qxe.1 uc291qxe.2 uc291qxe.1 uc291qxe.2 
ENSMUST00000104497.3 Gm22498 ENSMUST00000104497.3 Gm22498 (from geneSymbol) ENSMUST00000104497.1 ENSMUST00000104497.2 uc288uug.1 uc288uug.2 uc288uug.1 uc288uug.2 
ENSMUST00000104499.3 Gm22497 ENSMUST00000104499.3 Gm22497 (from geneSymbol) ENSMUST00000104499.1 ENSMUST00000104499.2 uc290oqu.1 uc290oqu.2 uc290oqu.1 uc290oqu.2 
ENSMUST00000104501.3 Gm22499 ENSMUST00000104501.3 Gm22499 (from geneSymbol) ENSMUST00000104501.1 ENSMUST00000104501.2 uc288rcw.1 uc288rcw.2 uc288rcw.1 uc288rcw.2 
ENSMUST00000104502.3 Gm24519 ENSMUST00000104502.3 Gm24519 (from geneSymbol) ENSMUST00000104502.1 ENSMUST00000104502.2 uc288mqn.1 uc288mqn.2 uc288mqn.1 uc288mqn.2 
ENSMUST00000104503.4 Gm25344 ENSMUST00000104503.4 Gm25344 (from geneSymbol) ENSMUST00000104503.1 ENSMUST00000104503.2 ENSMUST00000104503.3 uc289min.1 uc289min.2 uc289min.1 uc289min.2 
ENSMUST00000104505.3 Gm25345 ENSMUST00000104505.3 Gm25345 (from geneSymbol) ENSMUST00000104505.1 ENSMUST00000104505.2 uc291slb.1 uc291slb.2 uc291slb.1 uc291slb.2 
ENSMUST00000104507.3 Gm25232 ENSMUST00000104507.3 Gm25232 (from geneSymbol) ENSMUST00000104507.1 ENSMUST00000104507.2 uc288osb.1 uc288osb.2 uc288osb.1 uc288osb.2 
ENSMUST00000104509.3 Gm25346 ENSMUST00000104509.3 Gm25346 (from geneSymbol) ENSMUST00000104509.1 ENSMUST00000104509.2 uc292fhx.1 uc292fhx.2 uc292fhx.1 uc292fhx.2 
ENSMUST00000104510.3 Snord12 ENSMUST00000104510.3 small nucleolar RNA, C/D box 12 (from RefSeq NR_028540.1) ENSMUST00000104510.1 ENSMUST00000104510.2 NR_028540 uc290csc.1 uc290csc.2 uc290csc.1 uc290csc.2 
ENSMUST00000104512.4 Gm24069 ENSMUST00000104512.4 Gm24069 (from geneSymbol) ENSMUST00000104512.1 ENSMUST00000104512.2 ENSMUST00000104512.3 uc288gau.1 uc288gau.2 uc288gau.1 uc288gau.2 
ENSMUST00000104513.2 Gm24068 ENSMUST00000104513.2 Gm24068 (from geneSymbol) ENSMUST00000104513.1 uc290lgs.1 uc290lgs.2 uc290lgs.1 uc290lgs.2 
ENSMUST00000104514.3 Gm24067 ENSMUST00000104514.3 Gm24067 (from geneSymbol) AK085695 ENSMUST00000104514.1 ENSMUST00000104514.2 uc292eyc.1 uc292eyc.2 uc292eyc.1 uc292eyc.2 
ENSMUST00000104515.3 Gm24066 ENSMUST00000104515.3 Gm24066 (from geneSymbol) ENSMUST00000104515.1 ENSMUST00000104515.2 uc288grw.1 uc288grw.2 uc288grw.1 uc288grw.2 
ENSMUST00000104516.3 Snord89 ENSMUST00000104516.3 small nucleolar RNA, C/D box 89 (from RefSeq NR_028555.2) ENSMUST00000104516.1 ENSMUST00000104516.2 NR_028555 uc011wju.1 uc011wju.2 uc011wju.3 uc011wju.1 uc011wju.2 uc011wju.3 
ENSMUST00000104519.3 Gm24070 ENSMUST00000104519.3 Gm24070 (from geneSymbol) ENSMUST00000104519.1 ENSMUST00000104519.2 uc288hjg.1 uc288hjg.2 uc288hjg.1 uc288hjg.2 
ENSMUST00000104520.3 Gm24071 ENSMUST00000104520.3 Gm24071 (from geneSymbol) ENSMUST00000104520.1 ENSMUST00000104520.2 uc289ltv.1 uc289ltv.2 uc289ltv.1 uc289ltv.2 
ENSMUST00000104521.3 Snora64 ENSMUST00000104521.3 small nucleolar RNA, H/ACA box 64 (from RefSeq NR_002897.2) ENSMUST00000104521.1 ENSMUST00000104521.2 NR_002897 uc289idm.1 uc289idm.2 uc289idm.1 uc289idm.2 
ENSMUST00000104522.3 Gm25727 ENSMUST00000104522.3 Gm25727 (from geneSymbol) ENSMUST00000104522.1 ENSMUST00000104522.2 uc290fjr.1 uc290fjr.2 uc290fjr.1 uc290fjr.2 
ENSMUST00000104523.3 AF357399 ENSMUST00000104523.3 snoRNA AF357399 (from RefSeq NR_028129.1) ENSMUST00000104523.1 ENSMUST00000104523.2 NR_028129 uc012fgs.1 uc012fgs.2 uc012fgs.3 uc012fgs.1 uc012fgs.2 uc012fgs.3 
ENSMUST00000104525.4 Gm25728 ENSMUST00000104525.4 Gm25728 (from geneSymbol) ENSMUST00000104525.1 ENSMUST00000104525.2 ENSMUST00000104525.3 uc292net.1 uc292net.2 uc292net.1 uc292net.2 
ENSMUST00000104526.3 Snord17 ENSMUST00000104526.3 small nucleolar RNA, C/D box 17 (from RefSeq NR_030762.1) ENSMUST00000104526.1 ENSMUST00000104526.2 NR_030762 uc012cfg.1 uc012cfg.2 uc012cfg.3 uc012cfg.1 uc012cfg.2 uc012cfg.3 
ENSMUST00000104528.3 Gm25725 ENSMUST00000104528.3 Gm25725 (from geneSymbol) ENSMUST00000104528.1 ENSMUST00000104528.2 uc291xch.1 uc291xch.2 uc291xch.1 uc291xch.2 
ENSMUST00000104529.3 Gm25726 ENSMUST00000104529.3 Gm25726 (from geneSymbol) ENSMUST00000104529.1 ENSMUST00000104529.2 uc291evg.1 uc291evg.2 uc291evg.1 uc291evg.2 
ENSMUST00000104530.3 Gm25723 ENSMUST00000104530.3 Gm25723 (from geneSymbol) ENSMUST00000104530.1 ENSMUST00000104530.2 uc289fai.1 uc289fai.2 uc289fai.1 uc289fai.2 
ENSMUST00000104531.3 Gm25724 ENSMUST00000104531.3 Gm25724 (from geneSymbol) ENSMUST00000104531.1 ENSMUST00000104531.2 uc288whs.1 uc288whs.2 uc288whs.1 uc288whs.2 
ENSMUST00000104538.3 Gm22900 ENSMUST00000104538.3 Gm22900 (from geneSymbol) ENSMUST00000104538.1 ENSMUST00000104538.2 uc290jkb.1 uc290jkb.2 uc290jkb.1 uc290jkb.2 
ENSMUST00000104540.3 Gm22899 ENSMUST00000104540.3 Gm22899 (from geneSymbol) ENSMUST00000104540.1 ENSMUST00000104540.2 uc290ety.1 uc290ety.2 uc290ety.1 uc290ety.2 
ENSMUST00000104542.3 Gm23609 ENSMUST00000104542.3 Gm23609 (from geneSymbol) ENSMUST00000104542.1 ENSMUST00000104542.2 uc292izf.1 uc292izf.2 uc292izf.1 uc292izf.2 
ENSMUST00000104545.3 Gm23608 ENSMUST00000104545.3 Gm23608 (from geneSymbol) ENSMUST00000104545.1 ENSMUST00000104545.2 LF193125 uc289sxd.1 uc289sxd.2 uc289sxd.1 uc289sxd.2 
ENSMUST00000104546.3 Snord83b ENSMUST00000104546.3 small nucleolar RNA, C/D box 83B (from RefSeq NR_028282.1) ENSMUST00000104546.1 ENSMUST00000104546.2 NR_028282 uc011zwf.1 uc011zwf.2 uc011zwf.3 uc011zwf.1 uc011zwf.2 uc011zwf.3 
ENSMUST00000104547.3 Gm24556 ENSMUST00000104547.3 Gm24556 (from geneSymbol) ENSMUST00000104547.1 ENSMUST00000104547.2 uc291bvg.1 uc291bvg.2 uc291bvg.1 uc291bvg.2 
ENSMUST00000104548.3 Gm24555 ENSMUST00000104548.3 Gm24555 (from geneSymbol) ENSMUST00000104548.1 ENSMUST00000104548.2 uc287juf.1 uc287juf.2 uc287juf.1 uc287juf.2 
ENSMUST00000104549.3 Snord72 ENSMUST00000104549.3 small nucleolar RNA, C/D box 72 (from RefSeq NR_028091.1) ENSMUST00000104549.1 ENSMUST00000104549.2 NR_028091 uc011zqz.1 uc011zqz.2 uc011zqz.3 uc011zqz.1 uc011zqz.2 uc011zqz.3 
ENSMUST00000104550.2 Gm23607 ENSMUST00000104550.2 Gm23607 (from geneSymbol) ENSMUST00000104550.1 uc290lue.1 uc290lue.2 uc290lue.1 uc290lue.2 
ENSMUST00000104553.3 Gm26344 ENSMUST00000104553.3 Gm26344 (from geneSymbol) ENSMUST00000104553.1 ENSMUST00000104553.2 uc290iyp.1 uc290iyp.2 uc290iyp.1 uc290iyp.2 
ENSMUST00000104556.3 Gm26343 ENSMUST00000104556.3 Gm26343 (from geneSymbol) ENSMUST00000104556.1 ENSMUST00000104556.2 uc290ghs.1 uc290ghs.2 uc290ghs.1 uc290ghs.2 
ENSMUST00000104557.3 Gm26342 ENSMUST00000104557.3 Gm26342 (from geneSymbol) ENSMUST00000104557.1 ENSMUST00000104557.2 uc287iyc.1 uc287iyc.2 uc287iyc.1 uc287iyc.2 
ENSMUST00000104561.3 Gm26341 ENSMUST00000104561.3 Gm26341 (from geneSymbol) ENSMUST00000104561.1 ENSMUST00000104561.2 uc287qmt.1 uc287qmt.2 uc287qmt.1 uc287qmt.2 
ENSMUST00000104562.3 Gm23910 ENSMUST00000104562.3 Gm23910 (from geneSymbol) ENSMUST00000104562.1 ENSMUST00000104562.2 uc288fwq.1 uc288fwq.2 uc288fwq.1 uc288fwq.2 
ENSMUST00000104564.3 Gm23530 ENSMUST00000104564.3 Gm23530 (from geneSymbol) ENSMUST00000104564.1 ENSMUST00000104564.2 uc288xza.1 uc288xza.2 uc288xza.1 uc288xza.2 
ENSMUST00000104568.3 Snord90 ENSMUST00000104568.3 small nucleolar RNA, C/D box 90 (from RefSeq NR_028535.1) ENSMUST00000104568.1 ENSMUST00000104568.2 NR_028535 uc012bur.1 uc012bur.2 uc012bur.3 uc012bur.1 uc012bur.2 uc012bur.3 
ENSMUST00000104569.3 Gm23532 ENSMUST00000104569.3 Gm23532 (from geneSymbol) ENSMUST00000104569.1 ENSMUST00000104569.2 uc290vnm.1 uc290vnm.2 uc290vnm.1 uc290vnm.2 
ENSMUST00000104570.3 Gm23527 ENSMUST00000104570.3 Gm23527 (from geneSymbol) ENSMUST00000104570.1 ENSMUST00000104570.2 uc291ict.1 uc291ict.2 uc291ict.1 uc291ict.2 
ENSMUST00000104571.3 Gm23528 ENSMUST00000104571.3 Gm23528 (from geneSymbol) ENSMUST00000104571.1 ENSMUST00000104571.2 uc287naj.1 uc287naj.2 uc287naj.1 uc287naj.2 
ENSMUST00000104573.3 Gm25214 ENSMUST00000104573.3 Gm25214 (from geneSymbol) ENSMUST00000104573.1 ENSMUST00000104573.2 uc290cvl.1 uc290cvl.2 uc290cvl.1 uc290cvl.2 
ENSMUST00000104579.3 Snora35 ENSMUST00000104579.3 small nucleolar RNA, H/ACA box 35 (from RefSeq NR_028446.1) ENSMUST00000104579.1 ENSMUST00000104579.2 NR_028446 uc012hpy.1 uc012hpy.2 uc012hpy.3 uc012hpy.1 uc012hpy.2 uc012hpy.3 
ENSMUST00000104580.3 Gm25216 ENSMUST00000104580.3 Gm25216 (from geneSymbol) ENSMUST00000104580.1 ENSMUST00000104580.2 uc289sbd.1 uc289sbd.2 uc289sbd.1 uc289sbd.2 
ENSMUST00000104581.3 Gm25215 ENSMUST00000104581.3 Gm25215 (from geneSymbol) ENSMUST00000104581.1 ENSMUST00000104581.2 uc289waj.1 uc289waj.2 uc289waj.1 uc289waj.2 
ENSMUST00000104584.3 Gm22373 ENSMUST00000104584.3 Gm22373 (from geneSymbol) ENSMUST00000104584.1 ENSMUST00000104584.2 uc291qvp.1 uc291qvp.2 uc291qvp.1 uc291qvp.2 
ENSMUST00000104588.3 Gm22371 ENSMUST00000104588.3 Gm22371 (from geneSymbol) ENSMUST00000104588.1 ENSMUST00000104588.2 uc287igq.1 uc287igq.2 uc287igq.1 uc287igq.2 
ENSMUST00000104589.3 Gm22372 ENSMUST00000104589.3 Gm22372 (from geneSymbol) ENSMUST00000104589.1 ENSMUST00000104589.2 uc291ucd.1 uc291ucd.2 uc291ucd.1 uc291ucd.2 
ENSMUST00000104592.3 Gm24161 ENSMUST00000104592.3 Gm24161 (from geneSymbol) ENSMUST00000104592.1 ENSMUST00000104592.2 uc290pxl.1 uc290pxl.2 uc290pxl.1 uc290pxl.2 
ENSMUST00000104594.3 Gm24160 ENSMUST00000104594.3 Gm24160 (from geneSymbol) ENSMUST00000104594.1 ENSMUST00000104594.2 uc287jpe.1 uc287jpe.2 uc287jpe.1 uc287jpe.2 
ENSMUST00000104595.4 Gm23907 ENSMUST00000104595.4 Gm23907 (from geneSymbol) ENSMUST00000104595.1 ENSMUST00000104595.2 ENSMUST00000104595.3 uc288ykf.1 uc288ykf.2 uc288ykf.1 uc288ykf.2 
ENSMUST00000104596.3 Gm23911 ENSMUST00000104596.3 Gm23911 (from geneSymbol) ENSMUST00000104596.1 ENSMUST00000104596.2 uc291qlx.1 uc291qlx.2 uc291qlx.1 uc291qlx.2 
ENSMUST00000104598.3 Gm23909 ENSMUST00000104598.3 Gm23909 (from geneSymbol) ENSMUST00000104598.1 ENSMUST00000104598.2 uc288sls.1 uc288sls.2 uc288sls.1 uc288sls.2 
ENSMUST00000104599.3 Gm23908 ENSMUST00000104599.3 Gm23908 (from geneSymbol) ENSMUST00000104599.1 ENSMUST00000104599.2 uc291ifx.1 uc291ifx.2 uc291ifx.1 uc291ifx.2 
ENSMUST00000104603.4 Gm25563 ENSMUST00000104603.4 Gm25563 (from geneSymbol) ENSMUST00000104603.1 ENSMUST00000104603.2 ENSMUST00000104603.3 uc288hhe.1 uc288hhe.2 uc288hhe.1 uc288hhe.2 
ENSMUST00000104605.4 Gm25565 ENSMUST00000104605.4 Gm25565 (from geneSymbol) ENSMUST00000104605.1 ENSMUST00000104605.2 ENSMUST00000104605.3 uc292rwq.1 uc292rwq.2 uc292rwq.1 uc292rwq.2 
ENSMUST00000104606.4 Gm25560 ENSMUST00000104606.4 Gm25560 (from geneSymbol) ENSMUST00000104606.1 ENSMUST00000104606.2 ENSMUST00000104606.3 uc287odr.1 uc287odr.2 uc287odr.1 uc287odr.2 
ENSMUST00000104607.3 Gm25561 ENSMUST00000104607.3 Gm25561 (from geneSymbol) ENSMUST00000104607.1 ENSMUST00000104607.2 uc290cgf.1 uc290cgf.2 uc290cgf.1 uc290cgf.2 
ENSMUST00000104608.3 Gm25562 ENSMUST00000104608.3 Gm25562 (from geneSymbol) ENSMUST00000104608.1 ENSMUST00000104608.2 uc292hgk.1 uc292hgk.2 uc292hgk.1 uc292hgk.2 
ENSMUST00000104609.3 Snord19 ENSMUST00000104609.3 small nucleolar RNA, C/D box 19 (from RefSeq NR_028523.2) ENSMUST00000104609.1 ENSMUST00000104609.2 NR_028523 uc288rzq.1 uc288rzq.2 uc288rzq.1 uc288rzq.2 
ENSMUST00000104610.4 Gm23803 ENSMUST00000104610.4 Gm23803 (from geneSymbol) ENSMUST00000104610.1 ENSMUST00000104610.2 ENSMUST00000104610.3 uc287rkp.1 uc287rkp.2 uc287rkp.1 uc287rkp.2 
ENSMUST00000104611.3 Gm25148 ENSMUST00000104611.3 Gm25148 (from geneSymbol) ENSMUST00000104611.1 ENSMUST00000104611.2 uc288ndx.1 uc288ndx.2 uc288ndx.1 uc288ndx.2 
ENSMUST00000104616.3 Gm24403 ENSMUST00000104616.3 Gm24403 (from geneSymbol) ENSMUST00000104616.1 ENSMUST00000104616.2 uc290gsf.1 uc290gsf.2 uc290gsf.1 uc290gsf.2 
ENSMUST00000104627.3 Mir290a ENSMUST00000104627.3 microRNA 290a (from RefSeq NR_029640.1) ENSMUST00000104627.1 ENSMUST00000104627.2 NR_029640 uc012ewc.1 uc012ewc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608431.1 [ECO:0000345] ##Evidence-Data-END## uc012ewc.1 uc012ewc.2 
ENSMUST00000104644.3 Mir669d ENSMUST00000104644.3 microRNA 669d (from RefSeq NR_130323.1) ENSMUST00000104644.1 ENSMUST00000104644.2 NR_130323 uc056zjm.1 uc056zjm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zjm.1 uc056zjm.2 
ENSMUST00000104655.3 Mir105 ENSMUST00000104655.3 microRNA 105 (from RefSeq NR_030546.1) ENSMUST00000104655.1 ENSMUST00000104655.2 NR_030546 uc012hjx.1 uc012hjx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012hjx.1 uc012hjx.2 
ENSMUST00000104659.2 Mir876 ENSMUST00000104659.2 microRNA 876 (from RefSeq NR_030545.1) ENSMUST00000104659.1 NR_030545 uc012dbs.1 uc012dbs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609915.1 [ECO:0000345] ##Evidence-Data-END## uc012dbs.1 uc012dbs.2 
ENSMUST00000104662.3 Mir465b-1 ENSMUST00000104662.3 microRNA 465b-1 (from RefSeq NR_030560.1) ENSMUST00000104662.1 ENSMUST00000104662.2 NR_030560 uc012hix.1 uc012hix.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609924.1, LM609925.1 [ECO:0000345] ##Evidence-Data-END## uc012hix.1 uc012hix.2 
ENSMUST00000104677.3 Mir344e ENSMUST00000104677.3 microRNA 344e (from RefSeq NR_037284.1) ENSMUST00000104677.1 ENSMUST00000104677.2 NR_037284 uc012fmd.1 uc012fmd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610941.1 [ECO:0000345] ##Evidence-Data-END## uc012fmd.1 uc012fmd.2 
ENSMUST00000104680.3 Mir878 ENSMUST00000104680.3 microRNA 878 (from RefSeq NR_030603.1) ENSMUST00000104680.1 ENSMUST00000104680.2 NR_030603 uc012hiq.1 uc012hiq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609954.1 [ECO:0000345] ##Evidence-Data-END## uc012hiq.1 uc012hiq.2 
ENSMUST00000104689.3 Mir882 ENSMUST00000104689.3 microRNA 882 (from RefSeq NR_030540.1) ENSMUST00000104689.1 ENSMUST00000104689.2 NR_030540 uc011ysx.1 uc011ysx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011ysx.1 uc011ysx.2 
ENSMUST00000104694.3 Mir295 ENSMUST00000104694.3 microRNA 295 (from RefSeq NR_029645.1) ENSMUST00000104694.1 ENSMUST00000104694.2 NR_029645 uc291kno.1 uc291kno.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608436.1 [ECO:0000345] ##Evidence-Data-END## uc291kno.1 uc291kno.2 
ENSMUST00000104698.3 Mir875 ENSMUST00000104698.3 microRNA 875 (from RefSeq NR_030606.1) ENSMUST00000104698.1 ENSMUST00000104698.2 NR_030606 uc011zsc.1 uc011zsc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609957.1 [ECO:0000345] ##Evidence-Data-END## uc011zsc.1 uc011zsc.2 
ENSMUST00000104703.3 Mir879 ENSMUST00000104703.3 microRNA 879 (from RefSeq NR_030537.1) ENSMUST00000104703.1 ENSMUST00000104703.2 NR_030537 uc012dsf.1 uc012dsf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609908.1 [ECO:0000345] ##Evidence-Data-END## uc012dsf.1 uc012dsf.2 
ENSMUST00000104704.3 Mir511 ENSMUST00000104704.3 microRNA 511 (from RefSeq NR_030609.1) ENSMUST00000104704.1 ENSMUST00000104704.2 NR_030609 uc012bqz.1 uc012bqz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609960.1 [ECO:0000345] ##Evidence-Data-END## uc012bqz.1 uc012bqz.2 
ENSMUST00000104710.3 Mir294 ENSMUST00000104710.3 microRNA 294 (from RefSeq NR_029644.1) ENSMUST00000104710.1 ENSMUST00000104710.2 NR_029644 uc291knn.1 uc291knn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608435.1 [ECO:0000345] ##Evidence-Data-END## uc291knn.1 uc291knn.2 
ENSMUST00000104728.3 Mir872 ENSMUST00000104728.3 microRNA 872 (from RefSeq NR_030604.1) ENSMUST00000104728.1 ENSMUST00000104728.2 NR_030604 uc012dhb.1 uc012dhb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012dhb.1 uc012dhb.2 
ENSMUST00000104732.3 Mir453 ENSMUST00000104732.3 microRNA 453 (from RefSeq NR_030559.1) ENSMUST00000104732.1 ENSMUST00000104732.2 NR_030559 uc011yuc.1 uc011yuc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011yuc.1 uc011yuc.2 
ENSMUST00000104735.3 Mir208b ENSMUST00000104735.3 microRNA 208b (from RefSeq NR_030607.1) ENSMUST00000104735.1 ENSMUST00000104735.2 NR_030607 uc011zlk.1 uc011zlk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609958.1 [ECO:0000345] ##Evidence-Data-END## uc011zlk.1 uc011zlk.2 
ENSMUST00000104738.3 Mir877 ENSMUST00000104738.3 microRNA 877 (from RefSeq NR_030608.1) ENSMUST00000104738.1 ENSMUST00000104738.2 NR_030608 uc012arz.1 uc012arz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609959.1 [ECO:0000345] ##Evidence-Data-END## uc012arz.1 uc012arz.2 
ENSMUST00000104748.3 Mir466h ENSMUST00000104748.3 microRNA 466h (from RefSeq NR_030570.1) ENSMUST00000104748.1 ENSMUST00000104748.2 NR_030570 uc057lbz.1 uc057lbz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lbz.1 uc057lbz.2 
ENSMUST00000104751.4 Mir871 ENSMUST00000104751.4 microRNA 871 (from RefSeq NR_030536.1) ENSMUST00000104751.1 ENSMUST00000104751.2 ENSMUST00000104751.3 NR_030536 uc012hii.1 uc012hii.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609907.1 [ECO:0000345] ##Evidence-Data-END## uc012hii.1 uc012hii.2 
ENSMUST00000104757.3 Mir465c-2 ENSMUST00000104757.3 microRNA 465c-2 (from RefSeq NR_030563.1) ENSMUST00000104757.1 ENSMUST00000104757.2 NR_030563 uc012hiw.1 uc012hiw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012hiw.1 uc012hiw.2 
ENSMUST00000104761.3 Mir297a-4 ENSMUST00000104761.3 microRNA 297a-4 (from RefSeq NR_030552.1) ENSMUST00000104761.1 ENSMUST00000104761.2 NR_030552 uc057lcb.1 uc057lcb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lcb.1 uc057lcb.2 
ENSMUST00000104763.4 Mir743b ENSMUST00000104763.4 microRNA 743b (from RefSeq NR_030535.1) ENSMUST00000104763.1 ENSMUST00000104763.2 ENSMUST00000104763.3 NR_030535 uc012his.1 uc012his.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609906.1 [ECO:0000345] ##Evidence-Data-END## uc012his.1 uc012his.2 
ENSMUST00000104769.3 Mir874 ENSMUST00000104769.3 microRNA 874 (from RefSeq NR_030544.1) ENSMUST00000104769.1 ENSMUST00000104769.2 NR_030544 uc011zam.1 uc011zam.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609914.1 [ECO:0000345] ##Evidence-Data-END## uc011zam.1 uc011zam.2 
ENSMUST00000104779.3 Mir466f-1 ENSMUST00000104779.3 microRNA 466f-1 (from RefSeq NR_030566.1) ENSMUST00000104779.1 ENSMUST00000104779.2 NR_030566 uc057lbm.1 uc057lbm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lbm.1 uc057lbm.2 
ENSMUST00000104787.3 Mir654 ENSMUST00000104787.3 microRNA 654 (from RefSeq NR_030578.1) ENSMUST00000104787.1 ENSMUST00000104787.2 NR_030578 uc011yto.1 uc011yto.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011yto.1 uc011yto.2 
ENSMUST00000104788.3 Mir466f-3 ENSMUST00000104788.3 microRNA 466f-3 (from RefSeq NR_030568.1) ENSMUST00000104788.1 ENSMUST00000104788.2 NR_030568 uc057lbo.1 uc057lbo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lbo.1 uc057lbo.2 
ENSMUST00000104798.3 Mir466n ENSMUST00000104798.3 microRNA 466n (from RefSeq NR_037269.1) ENSMUST00000104798.1 ENSMUST00000104798.2 NR_037269 uc056zkv.1 uc056zkv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zkv.1 uc056zkv.2 
ENSMUST00000104803.3 Mir190b ENSMUST00000104803.3 microRNA 190b (from RefSeq NR_030543.1) ENSMUST00000104803.1 ENSMUST00000104803.2 NR_030543 uc012csr.1 uc012csr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609913.1 [ECO:0000345] ##Evidence-Data-END## uc012csr.1 uc012csr.2 
ENSMUST00000104805.3 Mir466f-2 ENSMUST00000104805.3 microRNA 466f-2 (from RefSeq NR_030567.1) ENSMUST00000104805.1 ENSMUST00000104805.2 NR_030567 uc057lbn.1 uc057lbn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lbn.1 uc057lbn.2 
ENSMUST00000104809.3 Mir880 ENSMUST00000104809.3 microRNA 880 (from RefSeq NR_030538.1) ENSMUST00000104809.1 ENSMUST00000104809.2 NR_030538 uc012hip.1 uc012hip.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609909.1 [ECO:0000345] ##Evidence-Data-END## uc012hip.1 uc012hip.2 
ENSMUST00000104815.3 Mir291a ENSMUST00000104815.3 microRNA 291a (from RefSeq NR_029641.1) ENSMUST00000104815.1 ENSMUST00000104815.2 NR_029641 uc012ewd.1 uc012ewd.2 uc012ewd.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608432.1 [ECO:0000345] ##Evidence-Data-END## uc012ewd.1 uc012ewd.2 uc012ewd.3 
ENSMUST00000104824.3 Mir883a ENSMUST00000104824.3 microRNA 883a (from RefSeq NR_030541.1) ENSMUST00000104824.1 ENSMUST00000104824.2 NR_030541 uc012hik.1 uc012hik.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609911.1 [ECO:0000345] ##Evidence-Data-END## uc012hik.1 uc012hik.2 
ENSMUST00000104830.3 Mir883b ENSMUST00000104830.3 microRNA 883b (from RefSeq NR_030542.1) ENSMUST00000104830.1 ENSMUST00000104830.2 NR_030542 uc012hil.1 uc012hil.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609912.1 [ECO:0000345] ##Evidence-Data-END## uc012hil.1 uc012hil.2 
ENSMUST00000104831.3 Mir466g ENSMUST00000104831.3 microRNA 466g (from RefSeq NR_030569.1) ENSMUST00000104831.1 ENSMUST00000104831.2 NR_030569 uc056zkx.1 uc056zkx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zkx.1 uc056zkx.2 
ENSMUST00000104832.3 Mir466o ENSMUST00000104832.3 microRNA 466o (from RefSeq NR_037248.1) ENSMUST00000104832.1 ENSMUST00000104832.2 NR_037248 uc057lbq.1 uc057lbq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lbq.1 uc057lbq.2 
ENSMUST00000104833.3 Mir449b ENSMUST00000104833.3 microRNA 449b (from RefSeq NR_030602.1) ENSMUST00000104833.1 ENSMUST00000104833.2 NR_030602 uc011zes.1 uc011zes.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011zes.1 uc011zes.2 
ENSMUST00000104837.3 Mir466d ENSMUST00000104837.3 microRNA 466d (from RefSeq NR_030601.1) ENSMUST00000104837.1 ENSMUST00000104837.2 NR_030601 uc057lby.1 uc057lby.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057lby.1 uc057lby.2 
ENSMUST00000104838.3 Mir291b ENSMUST00000104838.3 microRNA 291b (from RefSeq NR_030276.1) ENSMUST00000104838.1 ENSMUST00000104838.2 NR_030276 uc291knl.1 uc291knl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609546.1 [ECO:0000345] ##Evidence-Data-END## uc291knl.1 uc291knl.2 
ENSMUST00000104841.3 Mir293 ENSMUST00000104841.3 microRNA 293 (from RefSeq NR_029643.1) ENSMUST00000104841.1 ENSMUST00000104841.2 NR_029643 uc291knm.1 uc291knm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608434.1 [ECO:0000345] ##Evidence-Data-END## uc291knm.1 uc291knm.2 
ENSMUST00000104844.3 Mir881 ENSMUST00000104844.3 microRNA 881 (from RefSeq NR_030539.1) ENSMUST00000104844.1 ENSMUST00000104844.2 NR_030539 uc012hir.1 uc012hir.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609910.1 [ECO:0000345] ##Evidence-Data-END## uc012hir.1 uc012hir.2 
ENSMUST00000104847.3 Mir292 ENSMUST00000104847.3 microRNA 292 (from RefSeq NR_029642.1) ENSMUST00000104847.1 ENSMUST00000104847.2 NR_029642 uc291knk.1 uc291knk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608433.1 [ECO:0000345] ##Evidence-Data-END## uc291knk.1 uc291knk.2 
ENSMUST00000104863.2 Mir873a ENSMUST00000104863.2 microRNA 873a (from RefSeq NR_030605.1) ENSMUST00000104863.1 NR_030605 uc012dbt.1 uc012dbt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012dbt.1 uc012dbt.2 
ENSMUST00000104866.3 Mir466l ENSMUST00000104866.3 microRNA 466l (from RefSeq NR_130322.1) ENSMUST00000104866.1 ENSMUST00000104866.2 NR_130322 uc056zky.1 uc056zky.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zky.1 uc056zky.2 
ENSMUST00000104874.3 Or8d1 ENSMUST00000104874.3 olfactory receptor family 8 subfamily D member 1 (from RefSeq NM_146783.2) ENSMUST00000104874.1 ENSMUST00000104874.2 NM_146783 Olfr26 Olfr930 Or8d1 Q7TRB7 Q7TRB7_MOUSE uc009oxh.1 uc009oxh.2 uc009oxh.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC130238.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oxh.1 uc009oxh.2 uc009oxh.3 
ENSMUST00000104881.5 Or51f1e ENSMUST00000104881.5 olfactory receptor family 51 subfamily F member 1E (from RefSeq NM_147087.2) E9PXW4 E9PXW4_MOUSE ENSMUST00000104881.1 ENSMUST00000104881.2 ENSMUST00000104881.3 ENSMUST00000104881.4 NM_147087 Olfr585 Or51f1e uc009itd.1 uc009itd.2 uc009itd.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC145897.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009itd.1 uc009itd.2 uc009itd.3 
ENSMUST00000104915.3 Gm16485 ENSMUST00000104915.3 Gm16485 (from geneSymbol) ENSMUST00000104915.1 ENSMUST00000104915.2 uc292eju.1 uc292eju.2 uc292eju.1 uc292eju.2 
ENSMUST00000104922.3 Gm5071 ENSMUST00000104922.3 predicted pseudogene 5071 (from RefSeq NM_001256004.1) ENSMUST00000104922.1 ENSMUST00000104922.2 NM_001256004 uc029xlm.1 uc029xlm.2 uc029xlm.3 uc029xlm.4 uc029xlm.1 uc029xlm.2 uc029xlm.3 uc029xlm.4 
ENSMUST00000104926.3 Fam170b ENSMUST00000104926.3 family with sequence similarity 170, member B (from RefSeq NM_001164485.2) E9PXT9 ENSMUST00000104926.1 ENSMUST00000104926.2 F170B_MOUSE Fam170b NM_001164485 uc011ziq.1 uc011ziq.2 uc011ziq.3 Plays a role in fertilization through the acrosome reaction. Interacts with GOPC. Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane Exclusively expressed in adult testis (at protein level). Expression first started at postnatal week 3 in round spermatids, elongated spermatids and mature sperm. Belongs to the FAM170 family. acrosomal vesicle outer acrosomal membrane molecular_function membrane cytoplasmic vesicle regulation of fertilization positive regulation of acrosome reaction uc011ziq.1 uc011ziq.2 uc011ziq.3 
ENSMUST00000104928.2 Actl10 ENSMUST00000104928.2 actin-like 10 (from RefSeq NM_001171640.2) A2AKE7 ACL10_MOUSE ENSMUST00000104928.1 NM_001171640 uc012cgx.1 uc012cgx.2 Belongs to the actin family. molecular_function biological_process actin cytoskeleton uc012cgx.1 uc012cgx.2 
ENSMUST00000104929.2 Krtap4-24 ENSMUST00000104929.2 Krtap4-24 (from geneSymbol) B1AQ89 B1AQ89_MOUSE ENSMUST00000104929.1 Gm11555 uc288cbu.1 uc288cbu.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc288cbu.1 uc288cbu.2 
ENSMUST00000104930.2 Krtap1-3 ENSMUST00000104930.2 keratin associated protein 1-3 (from RefSeq NM_001085526.2) A2A588 A2A588_MOUSE ENSMUST00000104930.1 Krtap1-3 NM_001085526 uc007lje.1 uc007lje.2 uc007lje.3 uc007lje.4 uc007lje.5 molecular_function cellular_component biological_process keratin filament uc007lje.1 uc007lje.2 uc007lje.3 uc007lje.4 uc007lje.5 
ENSMUST00000104931.2 Gm11939 ENSMUST00000104931.2 Gm11939 (from geneSymbol) A2A592 A2A592_MOUSE ENSMUST00000104931.1 Gm11939 uc288cbt.1 uc288cbt.2 molecular_function structural molecule activity cellular_component biological_process keratin filament uc288cbt.1 uc288cbt.2 
ENSMUST00000104934.2 Adra2b ENSMUST00000104934.2 adrenergic receptor, alpha 2b (from RefSeq NM_009633.4) Adra2b ENSMUST00000104934.1 NM_009633 Q925K6 Q925K6_MOUSE uc290agf.1 uc290agf.2 Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily. G-protein coupled receptor activity adrenergic receptor activity alpha2-adrenergic receptor activity plasma membrane regulation of smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane regulation of vasoconstriction platelet activation adrenergic receptor signaling pathway uc290agf.1 uc290agf.2 
ENSMUST00000104936.4 Mageb3 ENSMUST00000104936.4 MAGE family member B3 (from RefSeq NM_008545.2) ENSMUST00000104936.1 ENSMUST00000104936.2 ENSMUST00000104936.3 Mageb3 NM_008545 Q9D2H4 Q9D2H4_MOUSE uc008lzv.1 uc008lzv.2 uc008lzv.3 molecular_function cellular_component biological_process uc008lzv.1 uc008lzv.2 uc008lzv.3 
ENSMUST00000104937.2 Ankrd63 ENSMUST00000104937.2 ankyrin repeat domain 63 (from RefSeq NM_001081971.1) A2ARS0 ANR63_MOUSE Ankrd63 ENSMUST00000104937.1 Gm1337 NM_001081971 uc008lsh.1 uc008lsh.2 molecular_function cellular_component biological_process uc008lsh.1 uc008lsh.2 
ENSMUST00000104941.4 H4c17 ENSMUST00000104941.4 H4 clustered histone 17 (from RefSeq NM_001195421.1) A0AUM5 A4FUP8 A4QMY0 ENSMUST00000104941.1 ENSMUST00000104941.2 ENSMUST00000104941.3 H4-12 H4-53 H4_MOUSE H4c1 H4c11 H4c12 H4c14 H4c16 H4c2 H4c3 H4c4 H4c6 H4c8 H4c9 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist1h4m Hist2h4 Hist2h4a Hist4h4 NM_001195421 P02304 P02305 P62806 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 uc007prr.1 uc007prr.2 uc007prr.3 uc007prr.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3- H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). P62806; Q8CDM1: Atad2; NbExp=2; IntAct=EBI-299632, EBI-2944582; P62806; Q9EQQ9: Oga; NbExp=2; IntAct=EBI-299632, EBI-8321615; Nucleus Chromosome Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Sumoylated, which is associated with transcriptional repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H4 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly DNA-templated transcription, initiation protein domain specific binding macromolecular complex negative regulation of megakaryocyte differentiation protein heterodimerization activity protein heterotetramerization uc007prr.1 uc007prr.2 uc007prr.3 uc007prr.4 
ENSMUST00000104942.2 AK157302 ENSMUST00000104942.2 Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. (from UniProt I3ITR1) AK157302 ENSMUST00000104942.1 I3ITR1 I3ITR1_MOUSE uc288lew.1 uc288lew.2 Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. Interacts with CRY2, but not with CRY1 (in vitro). Mitochondrion Belongs to the HesB/IscA family. structural molecule activity mitochondrion iron-sulfur cluster assembly iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding protein maturation by iron-sulfur cluster transfer uc288lew.1 uc288lew.2 
ENSMUST00000104947.5 Capns2 ENSMUST00000104947.5 calpain, small subunit 2 (from RefSeq NM_027112.1) CPNS2_MOUSE ENSMUST00000104947.1 ENSMUST00000104947.2 ENSMUST00000104947.3 ENSMUST00000104947.4 NM_027112 Q9D7J7 uc012gik.1 uc012gik.2 uc012gik.3 Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity (By similarity). Heterodimer of a large (catalytic) and a small (regulatory) subunit. Cytoplasm Cell membrane Note=Translocates to the plasma membrane upon calcium binding. calcium-dependent cysteine-type endopeptidase activity calcium ion binding protein binding cytoplasm plasma membrane proteolysis membrane metal ion binding uc012gik.1 uc012gik.2 uc012gik.3 
ENSMUST00000104954.9 Oser1 ENSMUST00000104954.9 oxidative stress responsive serine rich 1, transcript variant 2 (from RefSeq NM_001418537.1) A2A477 ENSMUST00000104954.1 ENSMUST00000104954.2 ENSMUST00000104954.3 ENSMUST00000104954.4 ENSMUST00000104954.5 ENSMUST00000104954.6 ENSMUST00000104954.7 ENSMUST00000104954.8 NM_001418537 OSER1_MOUSE Q3U5N3 Q9CXJ2 Q9D722 Q9D9G1 uc008nsr.1 uc008nsr.2 uc008nsr.3 molecular_function cellular_component cellular response to hydrogen peroxide uc008nsr.1 uc008nsr.2 uc008nsr.3 
ENSMUST00000104955.4 Sowaha ENSMUST00000104955.4 sosondowah ankyrin repeat domain family member A (from RefSeq NM_183173.2) Ankrd43 ENSMUST00000104955.1 ENSMUST00000104955.2 ENSMUST00000104955.3 NM_183173 Q149C7 Q8BLS7 SWAHA_MOUSE uc007iwf.1 uc007iwf.2 uc007iwf.3 Belongs to the SOWAH family. Sequence=AAI17864.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC31573.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc007iwf.1 uc007iwf.2 uc007iwf.3 
ENSMUST00000104958.2 Psme2b ENSMUST00000104958.2 protease (prosome, macropain) activator subunit 2B (from RefSeq NM_001281472.1) ENSMUST00000104958.1 NM_001281472 PSME2b Q5SVP3 Q5SVP3_MOUSE uc033fux.1 uc033fux.2 uc033fux.3 uc033fux.4 This gene may encode proteasome activator complex subunit 2 protein (PMID: 10222192). This gene, located on chromosome 11, lacks a structured promoter and is intronless. It has also been described as a pseudogene (PMID: 9914329), however, it has an intact coding region and transcripts can be placed at this location unambiguously. An interferon-inducible gene located on chromosome 14, near the gene that encodes proteasome activator complex subunit 1 protein, is considered the functional gene. [provided by RefSeq, Jul 2013]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Heterodimer of PSME1 and PSME2, which forms a hexameric ring. Belongs to the PA28 family. proteasome complex proteasome activator complex uc033fux.1 uc033fux.2 uc033fux.3 uc033fux.4 
ENSMUST00000104959.2 Cdk2ap1rt ENSMUST00000104959.2 Inhibitor of cyclin-dependent kinase CDK2 (PubMed:10938106). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). (from UniProt O35207) B2RV53 BC103772 CDKA1_MOUSE Cdk2ap1 Cdkap1 Doc1 ENSMUST00000104959.1 O35207 Q3SYK3 Q6ZWZ1 uc287xrh.1 uc287xrh.2 Inhibitor of cyclin-dependent kinase CDK2 (PubMed:10938106). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Homodimer (By similarity). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (By similarity). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (By similarity). Interacts with monomeric unphosphorylated CDK2 (PubMed:10938106). Interacts with CDK2AP2 (By similarity). Interacts with GATAD2A (By similarity). Interacts with HDAC1 (By similarity). Interacts with HDAC2 (By similarity). Interacts with MBD2 (By similarity). Interacts with MBD3 (By similarity). Interacts with RBBP4 (By similarity). Interacts with RBBP7 (By similarity). Nucleus Chromosome Phosphorylated in vitro by IKBKE at Ser-45. Belongs to the CDK2AP family. in utero embryonic development positive regulation of protein phosphorylation nucleus nucleoplasm cytosol cell cycle perinuclear region of cytoplasm face morphogenesis DNA polymerase binding uc287xrh.1 uc287xrh.2 
ENSMUST00000104962.2 Fem1al ENSMUST00000104962.2 fem-1 homolog A like (from RefSeq NM_176829.2) B2RT26 ENSMUST00000104962.1 FM1AB_MOUSE Fem1ab Fem1al NM_176829 Q5RJ26 Q8C0T1 uc007ihr.1 uc007ihr.2 Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg- Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Protein modification; protein ubiquitination. Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter FEM1A. Mitochondrion Cytoplasm Belongs to the fem-1 family. Sequence=CAI26025.1; Type=Erroneous initiation; Evidence=; molecular_function ubiquitin-protein transferase activity cellular_component cytoplasm biological_process protein ubiquitination regulation of ubiquitin-protein transferase activity uc007ihr.1 uc007ihr.2 
ENSMUST00000104979.2 Rnf148 ENSMUST00000104979.2 ring finger protein 148 (from RefSeq NM_027754.1) ENSMUST00000104979.1 G3X9R7 Greul3 NM_027754 Q8CGR1 Q9D3V4 RN148_MOUSE uc009bbl.1 uc009bbl.2 uc009bbl.3 uc009bbl.4 Membrane ; Multi-pass membrane protein late endosome endoplasmic reticulum Golgi apparatus ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination metal ion binding ubiquitin protein ligase activity uc009bbl.1 uc009bbl.2 uc009bbl.3 uc009bbl.4 
ENSMUST00000104983.2 Rbm8a2 ENSMUST00000104983.2 Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (from UniProt A0A0N4SUH6) A0A0N4SUH6 A0A0N4SUH6_MOUSE BC132651 ENSMUST00000104983.1 Rbm8a2 uc007dty.1 uc007dty.2 uc007dty.3 uc007dty.4 Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A. Nucleus speckle cleus Cytoplasm Belongs to the RBM8A family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding nucleus cytoplasm RNA processing mRNA processing RNA splicing nuclear speck exon-exon junction complex mRNA transport uc007dty.1 uc007dty.2 uc007dty.3 uc007dty.4 
ENSMUST00000104984.4 Chml ENSMUST00000104984.4 choroideremia-like (from RefSeq NM_021350.3) A0A0R4J1A1 A0A0R4J1A1_MOUSE Chml ENSMUST00000104984.1 ENSMUST00000104984.2 ENSMUST00000104984.3 NM_021350 uc007dtr.1 uc007dtr.2 uc007dtr.3 uc007dtr.4 uc007dtr.5 Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Cytoplasm Belongs to the Rab GDI family. GDP-dissociation inhibitor activity GTPase activator activity nucleus nucleoplasm cytoplasm cytosol Rab-protein geranylgeranyltransferase complex intracellular protein transport small GTPase mediated signal transduction Rab GTPase binding protein geranylgeranylation positive regulation of GTPase activity regulation of catalytic activity uc007dtr.1 uc007dtr.2 uc007dtr.3 uc007dtr.4 uc007dtr.5 
ENSMUST00000104998.5 Tmem203 ENSMUST00000104998.5 transmembrane protein 203 (from RefSeq NM_177344.3) ENSMUST00000104998.1 ENSMUST00000104998.2 ENSMUST00000104998.3 ENSMUST00000104998.4 NM_177344 Q8BQ59 Q8R235 TM203_MOUSE uc008iqz.1 uc008iqz.2 uc008iqz.3 Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873). Interacts with ATP2A2, ITPR3 and STIM1. Endoplasmic reticulum membrane ; Multi-pass membrane protein Male mutants are sterile and exhibit a profound defect in spermatogenesis and spermagiogenesis. molecular_function endoplasmic reticulum endoplasmic reticulum membrane cellular calcium ion homeostasis spermatogenesis membrane integral component of membrane uc008iqz.1 uc008iqz.2 uc008iqz.3 
ENSMUST00000104999.4 Nrarp ENSMUST00000104999.4 Notch-regulated ankyrin repeat protein (from RefSeq NM_025980.2) ENSMUST00000104999.1 ENSMUST00000104999.2 ENSMUST00000104999.3 NM_025980 NRARP_MOUSE Q80UV7 Q91ZA8 Q9CZM1 uc008iqk.1 uc008iqk.2 uc008iqk.3 Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (By similarity). Involved in the regulation of canonical Wnt signaling by stabilizing LEF1 (By similarity). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and down-regulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (PubMed:21795391, PubMed:21998026). Interacts with LEF1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91ZA8-1; Sequence=Displayed; Name=2; IsoId=Q91ZA8-2; Sequence=VSP_032380, VSP_032381; Expressed at high levels in the brain, heart, colon, kidney, liver, lung and small intestine. Expressed in retina, most prominent in endothelial cells at the migrating point of the vasculature behind leading tip cells. Expressed in testis. During embryogenesis, expressed in several tissues in which cellular differentiation is regulated by the notch signaling pathway. At 10.5 dpc expressed in intersomatic vessels and in vessels of the limb buds with strongest expression at vascular branch points. Cyclic expression between 8.5 dpc and 10.5 dpc somitogenesis is dependent on DLL3. By Notch signaling via a CBF1/Su(H)/Lag-1 (CSL)-dependent pathway. Axial skeletal defects in newborn mice such as rib fusions, fused vertebral bodies and fused pedicles of the vertebrae; defects are influenced by the strain-specific genetic background. Embryos exhibit expansion and fusion of myotomes, dorsal root ganglia fusions and defects in projection of the spinal nerves. Embryos show increased level of Notch 1 intracellular domain (NICD) expression in presomitic mesoderm and somites (PubMed:21998026). In contrast, fewer somites and vertebrae found in -/- are linked to a longer segmentation clock period (PubMed:21795391). Defects in the radial expansion of the vascular plexus from the optic nerve head to the periphery, reduction of retinal vessel density; however, most of the defects in angiogenesis resolve over time (PubMed:19154719). Belongs to the NRARP family. negative regulation of transcription from RNA polymerase II promoter branching involved in blood vessel morphogenesis positive regulation of endothelial cell proliferation sprouting angiogenesis blood vessel endothelial cell proliferation involved in sprouting angiogenesis cellular_component Notch signaling pathway multicellular organism development regulation of cell-cell adhesion somite rostral/caudal axis specification negative regulation of T cell differentiation negative regulation of Notch signaling pathway positive regulation of canonical Wnt signaling pathway negative regulation of Notch signaling pathway involved in somitogenesis uc008iqk.1 uc008iqk.2 uc008iqk.3 
ENSMUST00000105001.4 H2al2a ENSMUST00000105001.4 H2A histone family member L2A (from RefSeq NM_026627.2) ENSMUST00000105001.1 ENSMUST00000105001.2 ENSMUST00000105001.3 H2AB1_MOUSE H2ab1 H2afb1 H2al2a NM_026627 Q9CQ70 Q9D9Q5 uc008ili.1 uc008ili.2 uc008ili.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC061062.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 25731851 ##RefSeq-Attributes-END## Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells (PubMed:28366643). Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (PubMed:19506029). Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes (PubMed:19506029). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers (PubMed:19506029). Incorporated into nucleosomes during late spermatogenesis (PubMed:19506029). Interacts with H2BC1/TH2B; preferentially dimerizes with H2BC1/TH2B to form nucleosomes (PubMed:17261847, PubMed:28366643). Nucleus Chromosome Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847). Highly expressed in adult testis, mainly in spermatocytes (PubMed:20008104, PubMed:20188161, PubMed:17261847). Expressed since postnatal day (P) 21, peaks at P30, and gradually decreases in the testis of aging mouse (PubMed:20008104, PubMed:20188161). Coexpressed with transition proteins during late spermiogenesis (PubMed:28366643). Strongly enriched in step 12-16 spermatids and accumulate during late spermiogenesis, in condensing spermatids (PubMed:17261847). Remains present in mature spermatozoa isolated from epididymis (PubMed:17261847). Rapidly disappears from the paternal pericentric heterochromatin regions after sperm-egg fusion (PubMed:18703863). Male mice are completely sterile due to defects in spermatogenesis. Chromatin in mature spermatozoa shows defects in density, due to impaired histone replacement by protamines. A significant proportion of Prm2 remains unprocessed. In contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications. Belongs to the histone H2A family. Although related to histone H2AB1 in human (AC P0C5Y9), it is unclear whether human and mouse H2AB1 proteins are involved in similar processes. In mouse, histone H2AB1 is specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells during spermatogenesis (PubMed:28366643). It is however unclear whether human protein, which participates in mRNA processing and is associated with active transcription, is also involved in nucleosomes to protamine replacement. nucleosome nuclear nucleosome nuclear chromatin DNA binding protein binding nucleus chromosome pericentric heterochromatin DNA packaging chromatin organization nucleosome assembly spermatogenesis cell differentiation spermatogenesis, exchange of chromosomal proteins histone binding DNA packaging complex protein heterodimerization activity uc008ili.1 uc008ili.2 uc008ili.3 
ENSMUST00000105004.2 Fthl17d ENSMUST00000105004.2 ferritin, heavy polypeptide-like 17, member D (from RefSeq NM_001099326.2) ENSMUST00000105004.1 Fthl17 Fthl17d NM_001099326 Q3SXD1 Q3SXD1_MOUSE uc009spl.1 uc009spl.2 uc009spl.3 uc009spl.4 Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. ferroxidase activity iron ion binding cytoplasm iron ion transport cellular iron ion homeostasis intracellular sequestering of iron ion ferrous iron binding ferric iron binding identical protein binding metal ion binding oxidation-reduction process uc009spl.1 uc009spl.2 uc009spl.3 uc009spl.4 
ENSMUST00000105006.2 Fthl17b ENSMUST00000105006.2 ferritin, heavy polypeptide-like 17, member B (from RefSeq NM_001085524.1) A2AHC5 A2AHC5_MOUSE ENSMUST00000105006.1 Fthl17b Gm5634 NM_001085524 uc009spj.1 uc009spj.2 Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. ferroxidase activity iron ion binding cytoplasm iron ion transport cellular iron ion homeostasis intracellular sequestering of iron ion ferrous iron binding ferric iron binding identical protein binding metal ion binding oxidation-reduction process uc009spj.1 uc009spj.2 
ENSMUST00000105007.3 Btbd35f7 ENSMUST00000105007.3 BTB domain containing 35, family member 7 (from RefSeq NM_001085523.1) A2BHG6 A2BHG6_MOUSE Btbd35f7 ENSMUST00000105007.1 ENSMUST00000105007.2 Gm14374 NM_001085523 uc009skt.1 uc009skt.2 molecular_function cellular_component biological_process uc009skt.1 uc009skt.2 
ENSMUST00000105011.4 Btbd35f4 ENSMUST00000105011.4 BTB domain containing 35, family member 4 (from RefSeq NM_001099643.2) A2CGC2 A2CGC2_MOUSE Btbd35f3 Btbd35f4 ENSMUST00000105011.1 ENSMUST00000105011.2 ENSMUST00000105011.3 NM_001099643 uc009skr.1 uc009skr.2 uc009skr.3 uc009skr.4 molecular_function cellular_component biological_process uc009skr.1 uc009skr.2 uc009skr.3 uc009skr.4 
ENSMUST00000105014.2 Btbd35f17 ENSMUST00000105014.2 BTB domain containing 35, family member 17 (from RefSeq NM_001085554.1) Btbd35f17 ENSMUST00000105014.1 Gm10922 L7MU81 L7MU81_MOUSE NM_001085554 uc029xhq.1 uc029xhq.2 molecular_function cellular_component biological_process uc029xhq.1 uc029xhq.2 
ENSMUST00000105015.3 Btbd35f28 ENSMUST00000105015.3 BTB domain containing 35, family member 28 (from RefSeq NM_001085543.1) A2CFD5 A2CFD5_MOUSE Btbd35f28 ENSMUST00000105015.1 ENSMUST00000105015.2 Gm14347 NM_001085543 uc009sko.1 uc009sko.2 molecular_function cellular_component biological_process uc009sko.1 uc009sko.2 
ENSMUST00000105017.5 Btbd35f21 ENSMUST00000105017.5 BTB domain containing 35, family member 21 (from RefSeq NM_001270669.1) A0A140T8Q5 A0A140T8Q5_MOUSE Btbd35f21 ENSMUST00000105017.1 ENSMUST00000105017.2 ENSMUST00000105017.3 ENSMUST00000105017.4 NM_001270669 uc033jpb.1 uc033jpb.2 uc033jpb.3 uc033jpb.1 uc033jpb.2 uc033jpb.3 
ENSMUST00000105019.3 Btbd35f18 ENSMUST00000105019.3 BTB domain containing 35, family member 18 (from RefSeq NM_001085545.1) Btbd35f18 ENSMUST00000105019.1 ENSMUST00000105019.2 Gm14345 L7MU83 L7MU83_MOUSE NM_001085545 uc009skk.1 uc009skk.2 molecular_function cellular_component biological_process uc009skk.1 uc009skk.2 
ENSMUST00000105020.2 Btbd35f11 ENSMUST00000105020.2 BTB domain containing 35, family member 11 (from RefSeq NM_001085551.1) A2BFZ7 A2BFZ7_MOUSE Btbd35f11 Btbd35f9 ENSMUST00000105020.1 NM_001085551 uc033jog.1 uc033jog.2 molecular_function cellular_component biological_process uc033jog.1 uc033jog.2 
ENSMUST00000105031.4 Klhdc7a ENSMUST00000105031.4 kelch domain containing 7A (from RefSeq NM_173427.2) A2APT9 ENSMUST00000105031.1 ENSMUST00000105031.2 ENSMUST00000105031.3 KLD7A_MOUSE NM_173427 Q80SV4 Q8C706 uc008vmt.1 uc008vmt.2 uc008vmt.3 Membrane ; Single-pass membrane protein Sequence=BAC35129.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC35129.1; Type=Frameshift; Evidence=; membrane integral component of membrane uc008vmt.1 uc008vmt.2 uc008vmt.3 
ENSMUST00000105032.4 Fam43b ENSMUST00000105032.4 family with sequence similarity 43, member B (from RefSeq NM_001081672.2) A2AM80 A2AM80_MOUSE ENSMUST00000105032.1 ENSMUST00000105032.2 ENSMUST00000105032.3 Fam43b NM_001081672 uc008vkx.1 uc008vkx.2 uc008vkx.3 uc008vkx.4 molecular_function cellular_component biological_process uc008vkx.1 uc008vkx.2 uc008vkx.3 uc008vkx.4 
ENSMUST00000105038.3 Rpl27rt ENSMUST00000105038.3 Cytoplasm (from UniProt W4VSN7) ENSMUST00000105038.1 ENSMUST00000105038.2 Gm3550 Rpl27rt W4VSN7 W4VSN7_MOUSE uc289oqm.1 uc289oqm.2 Cytoplasm Belongs to the eukaryotic ribosomal protein eL29 family. cytoplasmic translation molecular_function structural constituent of ribosome cellular_component ribosome translation biological_process cytosolic large ribosomal subunit uc289oqm.1 uc289oqm.2 
ENSMUST00000105046.4 Hmga1b ENSMUST00000105046.4 high mobility group AT-hook 1B, transcript variant 2 (from RefSeq NM_001166477.1) ENSMUST00000105046.1 ENSMUST00000105046.2 ENSMUST00000105046.3 Hmga1 NM_001166477 Q566K0 Q566K0_MOUSE uc033gby.1 uc033gby.2 uc033gby.3 uc033gby.4 HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. Interacts with HIPK2. Chromosome Nucleus Belongs to the HMGA family. chromatin DNA binding nucleus regulation of transcription, DNA-templated uc033gby.1 uc033gby.2 uc033gby.3 uc033gby.4 
ENSMUST00000105049.2 Krtap17-1 ENSMUST00000105049.2 keratin associated protein 17-1 (from RefSeq NM_001099774.2) A2A5X6 A2A5X6_MOUSE ENSMUST00000105049.1 Krtap17-1 NM_001099774 uc007ljz.1 uc007ljz.2 uc007ljz.3 uc007ljz.4 molecular_function biological_process uc007ljz.1 uc007ljz.2 uc007ljz.3 uc007ljz.4 
ENSMUST00000105050.4 Krtap16-1 ENSMUST00000105050.4 keratin associated protein 16-1 (from RefSeq NM_001256057.1) A2A5X5 ENSMUST00000105050.1 ENSMUST00000105050.2 ENSMUST00000105050.3 Gm11570 KR161_MOUSE NM_001256057 uc029rod.1 uc029rod.2 uc029rod.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the KRTAP type 16 family. molecular_function cellular_component intermediate filament biological_process keratin filament uc029rod.1 uc029rod.2 uc029rod.3 
ENSMUST00000105051.2 Krtap29-1 ENSMUST00000105051.2 keratin associated protein 29-1 (from RefSeq NM_001378510.1) A2A5X4 ENSMUST00000105051.1 Gm14195 KR291_MOUSE Kap29.2 NM_001378510 uc288cck.1 uc288cck.2 Belongs to the KRTAP type 10 family. molecular_function cellular_component intermediate filament biological_process keratin filament uc288cck.1 uc288cck.2 
ENSMUST00000105052.2 Krtap9-5 ENSMUST00000105052.2 keratin associated protein 9-5 (from RefSeq NM_001085527.2) A2A5X3 A2A5X3_MOUSE ENSMUST00000105052.1 Krtap9-5 NM_001085527 uc007ljy.1 uc007ljy.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc007ljy.1 uc007ljy.2 
ENSMUST00000105053.2 Krtap31-3 ENSMUST00000105053.2 predicted gene 11565 (from RefSeq NM_001126323.1) A2A4M7 A2A4M7_MOUSE ENSMUST00000105053.1 Gm11565 NM_001126323 uc011yew.1 uc011yew.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc011yew.1 uc011yew.2 
ENSMUST00000105054.3 Krtap4-27 ENSMUST00000105054.3 RIKEN cDNA 2300003K06 gene (from RefSeq NM_001195383.1) 2300003K06Rik A2A4M0 A2A4M0_MOUSE ENSMUST00000105054.1 ENSMUST00000105054.2 NM_001195383 uc011yet.1 uc011yet.2 uc011yet.3 molecular_function cellular_component intermediate filament biological_process keratin filament uc011yet.1 uc011yet.2 uc011yet.3 
ENSMUST00000105055.2 Krtap4-26 ENSMUST00000105055.2 predicted gene 11564 (from RefSeq NM_001100614.1) A2A4L9 A2A4L9_MOUSE ENSMUST00000105055.1 Gm11564 NM_001100614 uc007ljt.1 uc007ljt.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc007ljt.1 uc007ljt.2 
ENSMUST00000105056.2 Krtap4-20 ENSMUST00000105056.2 predicted gene 11554 (from RefSeq NM_001099313.2) B1AQB2 B1AQB2_MOUSE ENSMUST00000105056.1 Gm11554 NM_001099313 uc029rob.1 uc029rob.2 uc029rob.3 uc029rob.4 molecular_function cellular_component intermediate filament biological_process keratin filament uc029rob.1 uc029rob.2 uc029rob.3 uc029rob.4 
ENSMUST00000105057.2 Krtap4-21 ENSMUST00000105057.2 predicted gene 11569 (from RefSeq NM_001099312.1) B1AQB1 B1AQB1_MOUSE ENSMUST00000105057.1 Gm11569 NM_001099312 uc057kmi.1 uc057kmi.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc057kmi.1 uc057kmi.2 
ENSMUST00000105058.2 Krtap4-23 ENSMUST00000105058.2 predicted gene 11596 (from RefSeq NM_001099311.3) B1AQB0 B1AQB0_MOUSE ENSMUST00000105058.1 Gm11596 NM_001099311 uc007ljo.1 uc007ljo.2 uc007ljo.3 uc007ljo.4 molecular_function cellular_component intermediate filament biological_process keratin filament uc007ljo.1 uc007ljo.2 uc007ljo.3 uc007ljo.4 
ENSMUST00000105059.4 Krtap4-9 ENSMUST00000105059.4 keratin associated protein 4-9 (from RefSeq NM_001085548.2) B1AQA9 B1AQA9_MOUSE ENSMUST00000105059.1 ENSMUST00000105059.2 ENSMUST00000105059.3 Krtap4-9 NM_001085548 uc007ljn.1 uc007ljn.2 uc007ljn.3 uc007ljn.4 molecular_function cellular_component intermediate filament biological_process keratin filament uc007ljn.1 uc007ljn.2 uc007ljn.3 uc007ljn.4 
ENSMUST00000105066.2 Gm14180 ENSMUST00000105066.2 Gm14180 (from geneSymbol) B1AQA0 B1AQA0_MOUSE ENSMUST00000105066.1 Gm14180 uc288ccc.1 uc288ccc.2 molecular_function cellular_component biological_process uc288ccc.1 uc288ccc.2 
ENSMUST00000105073.2 Gm14190 ENSMUST00000105073.2 Gm14190 (from geneSymbol) B1AQ87 B1AQ87_MOUSE ENSMUST00000105073.1 Gm14190 uc288cbz.1 uc288cbz.2 molecular_function cellular_component biological_process uc288cbz.1 uc288cbz.2 
ENSMUST00000105077.2 Tas2r122 ENSMUST00000105077.2 taste receptor, type 2, member 122 (from RefSeq NM_001039128.1) D3YU55 D3YU55_MOUSE ENSMUST00000105077.1 NM_001039128 Tas2r122 uc009ejk.1 uc009ejk.2 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor T2R family. detection of chemical stimulus involved in sensory perception of bitter taste G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane bitter taste receptor activity response to stimulus sensory perception of taste uc009ejk.1 uc009ejk.2 
ENSMUST00000105098.6 Foxd1 ENSMUST00000105098.6 forkhead box D1 (from RefSeq NM_008242.2) ENSMUST00000105098.1 ENSMUST00000105098.2 ENSMUST00000105098.3 ENSMUST00000105098.4 ENSMUST00000105098.5 FOXD1_MOUSE Fkhl8 Freac4 Hfhbf2 NM_008242 Q3UQW8 Q61345 uc009van.1 uc009van.2 uc009van.3 Transcription factor involved in regulation of gene expression in a variety of processes including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (PubMed:15509772, PubMed:15634693, PubMed:9811586). Involved in transcriptional activation of PGF and C3 genes (By similarity). Nucleus Predominantly expressed in the CNS and temporal half of the retina. Also expressed in the condensed head mesenchyme, metanephric blastema of the developing kidney, cortex of the adrenal gland, condensed mesenchyme at the base of the follicles of vibrassae and cartilage perichondrium of the developing vertebrate. At 9.5 dpc embryos, expressed in a limited region of the neuroepithelium and also in the temporal half of the primary optic cup and the optic stalk. At 10.5 dpc, seen in the hypothalamus, temporal half of the optic stalk, and temporal hemiretina. At 12.5 dpc and 13.5 dpc a high expression is seen in regions of condensed mesenchyme of the head, and as neuroepithelial cells begin to differentiate and migrate outward from the ventricular zone, expression declines markedly. By 16.5 dpc levels are diminished and restricted to unfused pockets along the exhausted ventricular zone. Mice show disrupted cell identity in the ventrotemporal area of the retina and aberrant morphogenesis of the optic chiasm. Their kidneys remain fused, have a disorganised ureteric tree and fail to ascend to a lumbar position. Was originally assigned to be BF-2 (FOXG1). RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding branching involved in ureteric bud morphogenesis kidney development DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development axon guidance DNA binding, bending anatomical structure morphogenesis positive regulation of gene expression cell differentiation positive regulation of BMP signaling pathway luteinizing hormone secretion sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter dichotomous subdivision of terminal units involved in ureteric bud branching nephrogenic mesenchyme development metanephric nephron development metanephric capsule development metanephric capsule specification pattern specification involved in metanephros development positive regulation of kidney development uc009van.1 uc009van.2 uc009van.3 
ENSMUST00000105105.4 H3c4 ENSMUST00000105105.4 H3 clustered histone 4 (from RefSeq NM_178204.2) A3KMN6 ENSMUST00000105105.1 ENSMUST00000105105.2 ENSMUST00000105105.3 H3-143 H3-53 H3-B H3-F H3.2 H3.2-221 H3.2-614 H3.2-615 H3.2-616 H32_MOUSE H3b H3c13 H3c14 H3c15 H3c2 H3c3 H3c4 H3c6 H3c7 H3f Hist1h3b Hist1h3c Hist1h3d Hist1h3e Hist1h3f Hist2h3b Hist2h3c1 Hist2h3c2 Hist2h3ca1 Hist2h3ca2 NM_178204 P02295 P02297 P16105 P17269 P17320 P84228 Q60582 Q78E59 Q8CGN9 uc288llz.1 uc288llz.2 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer (By similarity). Interacts with DNAJC9, CHAF1A and CHAF1B (By similarity). P84228; Q8TF76-1: HASPIN; Xeno; NbExp=3; IntAct=EBI-2658213, EBI-15815652; Nucleus. Chromosome. Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity). Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys- 10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H3 family. Sequence=AAH94041.1; Type=Erroneous initiation; Evidence=; Sequence=AAO06264.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter nuclear chromosome chromatin nucleosome nuclear nucleosome DNA binding chromatin binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly macromolecular complex protein heterodimerization activity protein heterotetramerization regulation of gene silencing uc288llz.1 uc288llz.2 
ENSMUST00000105106.2 H2bc7 ENSMUST00000105106.2 H2B clustered histone 7 (from RefSeq NM_178195.3) ENSMUST00000105106.1 H2B1F_MOUSE H2b-f H2b-j H2b-l H2b-n H2bc11 H2bc13 H2bc15 H2bc7 Hist1h2bf Hist1h2bj Hist1h2bl Hist1h2bn NM_178195 P10853 Q5SZZ3 uc007puf.1 uc007puf.2 uc007puf.3 uc007puf.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: AI152799.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome innate immune response in mucosa DNA binding extracellular space nucleus nucleoplasm chromosome cytosol nucleosome assembly antibacterial humoral response identical protein binding protein heterodimerization activity defense response to Gram-positive bacterium uc007puf.1 uc007puf.2 uc007puf.3 uc007puf.4 
ENSMUST00000105107.2 H3c6 ENSMUST00000105107.2 H3 clustered histone 6 (from RefSeq NM_178205.3) A3KMN6 ENSMUST00000105107.1 H3-143 H3-53 H3-B H3-F H3.2 H3.2-221 H3.2-614 H3.2-615 H3.2-616 H32_MOUSE H3b H3c13 H3c14 H3c15 H3c2 H3c3 H3c4 H3c6 H3c7 H3f Hist1h3b Hist1h3c Hist1h3d Hist1h3e Hist1h3f Hist2h3b Hist2h3c1 Hist2h3c2 Hist2h3ca1 Hist2h3ca2 NM_178205 P02295 P02297 P16105 P17269 P17320 P84228 Q60582 Q78E59 Q8CGN9 uc007puc.1 uc007puc.2 uc007puc.3 uc007puc.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: SRR7345562.4519473.1, BC127042.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer (By similarity). Interacts with DNAJC9, CHAF1A and CHAF1B (By similarity). P84228; Q8TF76-1: HASPIN; Xeno; NbExp=3; IntAct=EBI-2658213, EBI-15815652; Nucleus. Chromosome. Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity). Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys- 10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H3 family. Sequence=AAH94041.1; Type=Erroneous initiation; Evidence=; Sequence=AAO06264.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter nuclear chromosome chromatin nucleosome nuclear nucleosome DNA binding chromatin binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly macromolecular complex protein heterodimerization activity protein heterotetramerization regulation of gene silencing uc007puc.1 uc007puc.2 uc007puc.3 uc007puc.4 
ENSMUST00000105110.4 Fam47c ENSMUST00000105110.4 family with sequence similarity 47, member C (from RefSeq NM_001164739.1) ENSMUST00000105110.1 ENSMUST00000105110.2 ENSMUST00000105110.3 Fam47a Fam47a-ps Fam47c NM_001164739 Q14BE7 Q14BE7_MOUSE uc012hlk.1 uc012hlk.2 uc012hlk.3 Belongs to the FAM47 family. molecular_function cellular_component biological_process uc012hlk.1 uc012hlk.2 uc012hlk.3 
ENSMUST00000105111.4 F8a ENSMUST00000105111.4 factor 8-associated gene A (from RefSeq NM_007978.3) ENSMUST00000105111.1 ENSMUST00000105111.2 ENSMUST00000105111.3 F8a1 HAP40_MOUSE Hap40 NM_007978 Q00558 Q3TLS9 Q9JJQ6 uc009tlk.1 uc009tlk.2 uc009tlk.3 RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity). The HTT-F8A1/F8A2/F8A3- RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility (PubMed:16476778). Interacts with HTT (via C-terminus) (PubMed:11035034). Interacts with RAB5A (By similarity). Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity). Cytoplasm cleus rly endosome Nucleus, nuclear body Note=Diffuse presence in the cytoplasm and accumulation in the nucleus (By similarity). In absence of HTT, F8A1/F8A2/F8A3 is concentred in cytoplasm (PubMed:11035034). Colocalized with HTT in endosomes (By similarity). In neuron found in intranuclear structures, the intranuclear rodlets (INRs), also known as rodlets of Roncoroni, in association with ubiquitin (PubMed:23749422). Produced abundantly in a wide variety of cell types. molecular_function protein binding nucleus cytoplasm early endosome biological_process nuclear body vesicle cytoskeletal trafficking negative regulation of proteasomal protein catabolic process uc009tlk.1 uc009tlk.2 uc009tlk.3 
ENSMUST00000105113.4 Tex13c1 ENSMUST00000105113.4 TEX13 family member C1 (from RefSeq NM_001195271.1) D3YU32 ENSMUST00000105113.1 ENSMUST00000105113.2 ENSMUST00000105113.3 Gm362 NM_001195271 T13C1_MOUSE Tex13c1 uc012hgq.1 uc012hgq.2 uc012hgq.3 Belongs to the TEX13 family. uc012hgq.1 uc012hgq.2 uc012hgq.3 
ENSMUST00000105117.3 Btbd35f14 ENSMUST00000105117.3 BTB domain containing 35, family member 14 (from RefSeq NM_001145038.1) Btbd35f14 ENSMUST00000105117.1 ENSMUST00000105117.2 Gm2933 Gmcl1l NM_001145038 Q1LZI5 Q1LZI5_MOUSE uc033jpe.1 uc033jpe.2 molecular_function cellular_component biological_process uc033jpe.1 uc033jpe.2 
ENSMUST00000105124.3 Spin2j ENSMUST00000105124.3 spindlin family, member 2J (from RefSeq NM_001270685.1) A0A140T8V2 E9PWJ8 E9PWJ8_MOUSE ENSMUST00000105124.1 ENSMUST00000105124.2 NM_001270685 Spin2h Spin2j uc029xja.1 uc029xja.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation biological_process methylated histone binding uc029xja.1 uc029xja.2 
ENSMUST00000105137.4 H2al1n ENSMUST00000105137.4 H2A histone family member L1N (from RefSeq NM_001034100.1) EG385328 ENSMUST00000105137.1 ENSMUST00000105137.2 ENSMUST00000105137.3 Gm5382 H2al1n L7MU91 NM_001034100 Q497L1 Q497L1_MOUSE uc009srw.1 uc009srw.2 uc009srw.3 The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc009srw.1 uc009srw.2 uc009srw.3 
ENSMUST00000105139.5 Sf3b5 ENSMUST00000105139.5 splicing factor 3b, subunit 5 (from RefSeq NM_175102.4) ENSMUST00000105139.1 ENSMUST00000105139.2 ENSMUST00000105139.3 ENSMUST00000105139.4 NM_175102 Q923D4 SF3B5_MOUSE Sf3b10 uc007eki.1 uc007eki.2 uc007eki.3 uc007eki.4 Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre- mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs. Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Part of the SF3B subcomplex of the 17S U2 SnRNP complex. SF3B associates with the splicing subcomplex SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Within the SF3B subcomplex, interacts directly with SF3B1 (via HEAT domain) and SF3B3. Component of the minor spliceosome, which splices U12-type introns. Nucleus Belongs to the SF3B5 family. mRNA splicing, via spliceosome molecular_function RNA binding nucleus nucleoplasm spliceosomal complex U2 snRNP U12-type spliceosomal complex mRNA processing RNA splicing U2-type precatalytic spliceosome splicing factor binding uc007eki.1 uc007eki.2 uc007eki.3 uc007eki.4 
ENSMUST00000105143.3 Ifna7 ENSMUST00000105143.3 interferon alpha 7 (from RefSeq NM_008334.3) D3YU14 ENSMUST00000105143.1 ENSMUST00000105143.2 If1ai9 Ifna14 Ifna7 NM_008334 Q810G6 Q810G6_MOUSE uc008tnx.1 uc008tnx.2 uc008tnx.3 uc008tnx.4 Secreted Belongs to the alpha/beta interferon family. cytokine activity cytokine receptor binding extracellular region extracellular space defense response signal transduction defense response to virus uc008tnx.1 uc008tnx.2 uc008tnx.3 uc008tnx.4 
ENSMUST00000105144.2 Ifnz ENSMUST00000105144.2 interferon zeta (from RefSeq NM_197889.2) ENSMUST00000105144.1 If1ha4 Ifnz NM_197889 Q8BQT1 Q8BQT1_MOUSE uc008tnp.1 uc008tnp.2 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus regulation of cell cycle apoptotic signaling pathway uc008tnp.1 uc008tnp.2 
ENSMUST00000105146.4 Ifna6 ENSMUST00000105146.4 interferon alpha 6 (from RefSeq NM_206871.3) B1AYH8 ENSMUST00000105146.1 ENSMUST00000105146.2 ENSMUST00000105146.3 If1ai11 Ifna6 NM_206871 Q810G5 Q810G5_MOUSE uc008tnz.1 uc008tnz.2 Secreted Belongs to the alpha/beta interferon family. cytokine activity cytokine receptor binding extracellular region extracellular space defense response signal transduction defense response to virus uc008tnz.1 uc008tnz.2 
ENSMUST00000105147.2 Ifna2 ENSMUST00000105147.2 interferon alpha 2 (from RefSeq NM_010503.2) B1AYH7 B1AYH7_MOUSE ENSMUST00000105147.1 If1ai7 Ifna2 NM_010503 uc008tni.1 uc008tni.2 uc008tni.3 Secreted Belongs to the alpha/beta interferon family. cytokine activity cytokine receptor binding extracellular region extracellular space defense response signal transduction defense response to virus uc008tni.1 uc008tni.2 uc008tni.3 
ENSMUST00000105148.2 Ifna16 ENSMUST00000105148.2 interferon alpha 16 (from RefSeq NM_206867.1) ENSMUST00000105148.1 Gm13280 If1ai6 Ifna16 Ifna6T NM_206867 OTTMUSG00000011275 Q810G1 Q810G1_MOUSE uc008tnh.1 uc008tnh.2 uc008tnh.3 Secreted Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tnh.1 uc008tnh.2 uc008tnh.3 
ENSMUST00000105149.3 Ifna13 ENSMUST00000105149.3 interferon alpha 13 (from RefSeq NM_177347.2) ENSMUST00000105149.1 ENSMUST00000105149.2 IFNAD_MOUSE NM_177347 Q80SU4 uc008tng.1 uc008tng.2 Exhibits antiviral activity against Theiler's virus, Mengo virus and vesicular stomatitis virus. Interferons alpha stimulate the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Secreted Transcribed constitutively. Not induces by viral infection. Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tng.1 uc008tng.2 
ENSMUST00000105158.2 Mos ENSMUST00000105158.2 Moloney sarcoma oncogene (from RefSeq NM_020021.3) E9PV67 ENSMUST00000105158.1 F6UHW1 MOS_MOUSE Mos NM_020021 P00536 Q61886 Q61887 Q78EH5 uc008rwo.1 uc008rwo.2 uc008rwo.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Expressed specifically in testis during spermatogenesis. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Sequence=AAB59724.1; Type=Erroneous gene model prediction; Evidence=; MAPK cascade nucleotide binding activation of MAPKK activity activation of MAPK activity meiotic spindle organization protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity ATP binding cytoplasm cytosol chromatin organization protein phosphorylation kinase activity phosphorylation transferase activity regulation of meiotic nuclear division positive regulation of MAPK cascade protein autophosphorylation establishment of meiotic spindle orientation negative regulation of metaphase/anaphase transition of meiotic cell cycle uc008rwo.1 uc008rwo.2 uc008rwo.3 
ENSMUST00000105159.5 Vmn1r3 ENSMUST00000105159.5 vomeronasal 1 receptor 3 (from RefSeq NM_001167535.1) A2AMT7 A2AMT7_MOUSE ENSMUST00000105159.1 ENSMUST00000105159.2 ENSMUST00000105159.3 ENSMUST00000105159.4 Gm4741 LOC171266 NM_001167535 OTTMUSG00000004181 Vmn1r3 uc008rwg.1 uc008rwg.2 uc008rwg.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc008rwg.1 uc008rwg.2 uc008rwg.3 
ENSMUST00000105187.3 Vmn1r254 ENSMUST00000105187.3 vomeronasal 1 receptor 254 (from RefSeq NM_001166751.1) ENSMUST00000105187.1 ENSMUST00000105187.2 Gm5728 Gm8660 K7N6J2 K7N6J2_MOUSE NM_001166751 Vmn1r244 Vmn1r254 uc012fdy.1 uc012fdy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fdy.1 uc012fdy.2 
ENSMUST00000105195.2 Vmn1r249 ENSMUST00000105195.2 vomeronasal 1 receptor 249 (from RefSeq NM_001166711.1) ENSMUST00000105195.1 Gm5725 Gm8720 K9J7F4 K9J7F4_MOUSE NM_001166711 Vmn1r249 Vmn1r260 uc012fdl.1 uc012fdl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fdl.1 uc012fdl.2 
ENSMUST00000105196.2 Vmn1r248 ENSMUST00000105196.2 vomeronasal 1 receptor 248 (from RefSeq NM_001167167.1) D3YTX3 D3YTX5 D3YTX5_MOUSE E9PW84 E9PYZ9 E9Q018 E9Q3T1 E9Q3V4 E9Q4Q4 E9Q5H4 E9Q8U4 ENSMUST00000105196.1 Gm4177 Gm4216 NM_001167167 Vmn1r248 Vmn1r259 uc012fdj.1 uc012fdj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fdj.1 uc012fdj.2 
ENSMUST00000105197.3 Vmn1r121 ENSMUST00000105197.3 vomeronasal 1 receptor 121 (from RefSeq NM_001166741.1) ENSMUST00000105197.1 ENSMUST00000105197.2 K7N6J4 K7N6J4_MOUSE NM_001166741 Vmn1r121 uc012fcv.1 uc012fcv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fcv.1 uc012fcv.2 
ENSMUST00000105199.2 Vmn1r127 ENSMUST00000105199.2 vomeronasal 1 receptor 127 (from RefSeq NM_001166726.1) ENSMUST00000105199.1 K7N6J5 K7N6J5_MOUSE NM_001166726 Vmn1r127 uc012fdb.1 uc012fdb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fdb.1 uc012fdb.2 
ENSMUST00000105200.2 Vmn1r124 ENSMUST00000105200.2 vomeronasal 1 receptor 124 (from RefSeq NM_001166757.1) D3YTX4 D3YTX4_MOUSE ENSMUST00000105200.1 NM_001166757 Vmn1r124 uc012fcy.1 uc012fcy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fcy.1 uc012fcy.2 
ENSMUST00000105202.3 Vmn1r120 ENSMUST00000105202.3 vomeronasal 1 receptor 120 (from RefSeq NM_001166715.1) ENSMUST00000105202.1 ENSMUST00000105202.2 K7N6J6 K7N6J6_MOUSE NM_001166715 Vmn1r120 uc012fcu.1 uc012fcu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fcu.1 uc012fcu.2 
ENSMUST00000105209.3 Vmn1r244 ENSMUST00000105209.3 vomeronasal 1 receptor 244 (from RefSeq NM_001166713.1) ENSMUST00000105209.1 ENSMUST00000105209.2 Gm5728 Gm8660 K7N6J2 K7N6J2_MOUSE NM_001166713 Vmn1r244 Vmn1r254 uc012fbw.1 uc012fbw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fbw.1 uc012fbw.2 
ENSMUST00000105230.4 Sarnp ENSMUST00000105230.4 SAP domain containing ribonucleoprotein, transcript variant 1 (from RefSeq NM_025364.3) ENSMUST00000105230.1 ENSMUST00000105230.2 ENSMUST00000105230.3 Hcc1 NM_025364 Q3UJZ4 Q9CU18 Q9D1J3 SARNP_MOUSE uc007hor.1 uc007hor.2 uc007hor.3 uc007hor.4 Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity). Interacts with DDX39A. Interacts with FUS. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex interacts directly with DDX39B in a ATP-dependent manner which bridges it to ALYREF/THOC4 (By similarity). Nucleus Nucleus speckle negative regulation of transcription from RNA polymerase II promoter transcription export complex RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding RNA binding protein binding nucleus mRNA export from nucleus regulation of translation protein C-terminus binding nuclear speck cytoplasmic ribonucleoprotein granule RS domain binding mRNA transport uc007hor.1 uc007hor.2 uc007hor.3 uc007hor.4 
ENSMUST00000105256.10 Ctdsp2 ENSMUST00000105256.10 CTD small phosphatase 2, transcript variant a (from RefSeq NM_001113470.1) CTDS2_MOUSE ENSMUST00000105256.1 ENSMUST00000105256.2 ENSMUST00000105256.3 ENSMUST00000105256.4 ENSMUST00000105256.5 ENSMUST00000105256.6 ENSMUST00000105256.7 ENSMUST00000105256.8 ENSMUST00000105256.9 NM_001113470 Q8BX07 uc007hhj.1 uc007hhj.2 uc007hhj.3 uc007hhj.4 Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per monomer. ; Monomer. Interacts with REST. Nucleus Expression is restricted to non-neuronal tissues. negative regulation of protein phosphorylation phosphoprotein phosphatase activity cellular_component nucleus regulation of transcription from RNA polymerase II promoter protein dephosphorylation CTD phosphatase activity hydrolase activity phosphatase activity metal ion binding negative regulation of G1/S transition of mitotic cell cycle uc007hhj.1 uc007hhj.2 uc007hhj.3 uc007hhj.4 
ENSMUST00000105262.9 Grip1 ENSMUST00000105262.9 glutamate receptor interacting protein 1, transcript variant 6 (from RefSeq NM_001277294.1) ENSMUST00000105262.1 ENSMUST00000105262.2 ENSMUST00000105262.3 ENSMUST00000105262.4 ENSMUST00000105262.5 ENSMUST00000105262.6 ENSMUST00000105262.7 ENSMUST00000105262.8 Grip1 H7BX90 H7BX90_MOUSE NM_001277294 uc007hem.1 uc007hem.2 uc007hem.3 uc007hem.4 This gene encodes a protein containing multiple PDZ (post synaptic density protein, Drosophila disc large tumor suppressor, and zonula occludens-1 protein) domains. The encoded protein acts as a mediator between cytoskeletal and membrane proteins, particularly in neuronal cells, and facilitates complex formation at the cell membrane. Mutation of this gene can cause embryonic lethality resulting from defects of the dermo-epidermal junction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. positive regulation of signal transduction dendrite development receptor signaling complex scaffold activity uc007hem.1 uc007hem.2 uc007hem.3 uc007hem.4 
ENSMUST00000105267.8 Cnot2 ENSMUST00000105267.8 CCR4-NOT transcription complex, subunit 2, transcript variant 11 (from RefSeq NM_001359252.1) CNOT2_MOUSE ENSMUST00000105267.1 ENSMUST00000105267.2 ENSMUST00000105267.3 ENSMUST00000105267.4 ENSMUST00000105267.5 ENSMUST00000105267.6 ENSMUST00000105267.7 NM_001359252 Q3UE39 Q80YA5 Q8C5L3 Q9D0P1 uc007hcc.1 uc007hcc.2 uc007hcc.3 uc007hcc.4 Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4- NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2 (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C5L3-1; Sequence=Displayed; Name=2; IsoId=Q8C5L3-2; Sequence=VSP_009918; Name=3; IsoId=Q8C5L3-3; Sequence=VSP_009917; Expressed in embryonic stem (ES) cells and in inner cell mass (ICM) of the blastocyst. Belongs to the CNOT2/3/5 family. Sequence=AAH43133.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter P-body RNA polymerase II transcription corepressor binding trophectodermal cell differentiation poly(A)-specific ribonuclease activity nucleus cytoplasm cytosol plasma membrane regulation of transcription, DNA-templated regulation of translation multicellular organism development positive regulation of cytoplasmic mRNA processing body assembly negative regulation of translation CCR4-NOT complex CCR4-NOT core complex gene silencing by RNA negative regulation of intracellular estrogen receptor signaling pathway RNA phosphodiester bond hydrolysis, exonucleolytic regulation of stem cell population maintenance uc007hcc.1 uc007hcc.2 uc007hcc.3 uc007hcc.4 
ENSMUST00000105275.9 Osbpl8 ENSMUST00000105275.9 oxysterol binding protein-like 8, transcript variant 1 (from RefSeq NM_175489.3) B9EJ86 ENSMUST00000105275.1 ENSMUST00000105275.2 ENSMUST00000105275.3 ENSMUST00000105275.4 ENSMUST00000105275.5 ENSMUST00000105275.6 ENSMUST00000105275.7 ENSMUST00000105275.8 G3X9N6 Kiaa1451 NM_175489 OSBL8_MOUSE Orp8 Osbpl8 Q69ZJ4 uc007gzy.1 uc007gzy.2 uc007gzy.3 This gene encodes a member of the oxysterol-binding protein (Osbp) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal Osbp-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol. Interacts with SPAG5. Interacts with NUP62. Endoplasmic reticulum membrane ; Single-pass membrane protein Nucleus membrane Note=The presence of the N-terminus extension contains an overall negative charge that may explain the weak localization to the cortical endoplasmic reticulum. Widely expressed. Most abundant in liver, spleen, kidney, brain and adipose tissue. Mice are apparently healthy and show no developmental defects nor gross abnormality of glucose or lipid metabolism. However, they display a significant elevation of plasma HDL cholesterol and phospholipid levels. They also show a modest increase of APOA1, plus a number of mild gender- or diet-specific lipid metabolism phenotypes (PubMed:23554939). Deletion in bone marrow- derived cells, including macrophages, reduces atherosclerotic lesion progression (PubMed:25347070). Belongs to the OSBP family. Sequence=EDL21722.1; Type=Erroneous gene model prediction; Evidence=; phosphatidylserine binding protein binding nucleus endoplasmic reticulum endoplasmic reticulum membrane cytosol lipid transport lipid binding negative regulation of sequestering of triglyceride cholesterol binding phospholipid transport membrane integral component of membrane negative regulation of cell migration nuclear membrane activation of protein kinase B activity cortical endoplasmic reticulum sterol binding intracellular membrane-bounded organelle fat cell differentiation positive regulation of glucose import positive regulation of insulin receptor signaling pathway positive regulation of protein kinase B signaling phosphatidylinositol-4-phosphate binding protein localization to nuclear pore uc007gzy.1 uc007gzy.2 uc007gzy.3 
ENSMUST00000105283.9 Kitl ENSMUST00000105283.9 kit ligand, transcript variant 1 (from RefSeq NM_013598.3) ENSMUST00000105283.1 ENSMUST00000105283.2 ENSMUST00000105283.3 ENSMUST00000105283.4 ENSMUST00000105283.5 ENSMUST00000105283.6 ENSMUST00000105283.7 ENSMUST00000105283.8 Kitlg Mgf NM_013598 P20826 P97332 Q3TNJ7 Q62524 Q64222 Q921N5 SCF_MOUSE Sl Slf uc007gxp.1 uc007gxp.2 uc007gxp.3 Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. [Isoform 1]: Cell membrane ; Single- pass type I membrane protein [Isoform 2]: Cytoplasm Cytoplasm, cytoskeleton Cell membrane ; Single-pass type I membrane protein Cytoplasm, cytoskeleton Cell projection, lamellipodium Cell projection, filopodium [Soluble KIT ligand]: Secreted Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=KL-1; IsoId=P20826-1; Sequence=Displayed; Name=2; Synonyms=KL-2; IsoId=P20826-2; Sequence=VSP_006023; Expressed in the cochlea. Acts in the early stages of hematopoiesis. A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain. Belongs to the SCF family. ovarian follicle development neural crest cell migration positive regulation of leukocyte migration positive regulation of myeloid leukocyte differentiation cytokine activity stem cell factor receptor binding protein binding extracellular region extracellular space cytoplasm cytoskeleton plasma membrane cell adhesion germ cell development growth factor activity positive regulation of cell proliferation male gonad development membrane integral component of membrane lamellipodium filopodium negative regulation of mast cell apoptotic process embryonic hemopoiesis ectopic germ cell programmed cell death cell projection negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of melanocyte differentiation positive regulation of Ras protein signal transduction positive regulation of peptidyl-tyrosine phosphorylation positive regulation of mast cell proliferation extrinsic apoptotic signaling pathway in absence of ligand positive regulation of hematopoietic stem cell proliferation uc007gxp.1 uc007gxp.2 uc007gxp.3 
ENSMUST00000105286.4 Kera ENSMUST00000105286.4 keratocan (from RefSeq NM_008438.3) ENSMUST00000105286.1 ENSMUST00000105286.2 ENSMUST00000105286.3 KERA_MOUSE Ktcn NM_008438 O35367 uc007gxa.1 uc007gxa.2 uc007gxa.3 May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. Secreted, extracellular space, extracellular matrix Selectively expressed in cornea of adult where it is detected in keratocytes but not in scleral cells. In embryo, first detected in periocular mesenchymal cells migrating toward developing cornea on 13.5 dpc; expression gradually restricted to corneal stromal cells on 14.5 to 18.5 dpc. Detected in scleral cells of 15.5 dpc but not in 18.5 dpc embryos. Binds keratan sulfate chains. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. extracellular region cornea development in camera-type eye uc007gxa.1 uc007gxa.2 uc007gxa.3 
ENSMUST00000105287.11 Dcn ENSMUST00000105287.11 decorin, transcript variant 1 (from RefSeq NM_001190451.2) Dcn ENSMUST00000105287.1 ENSMUST00000105287.10 ENSMUST00000105287.2 ENSMUST00000105287.3 ENSMUST00000105287.4 ENSMUST00000105287.5 ENSMUST00000105287.6 ENSMUST00000105287.7 ENSMUST00000105287.8 ENSMUST00000105287.9 NM_001190451 Q3UKR1 Q3UKR1_MOUSE uc007gwx.1 uc007gwx.2 uc007gwx.3 uc007gwx.4 uc007gwx.5 This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. May affect the rate of fibrils formation. Binds to type I and type II collagen, fibronectin and TGF- beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT. Secreted, extracellular space, extracellular matrix Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. kidney development placenta development collagen binding extracellular region collagen type VI trimer skeletal muscle tissue development aging response to mechanical stimulus positive regulation of autophagy negative regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of macroautophagy negative regulation of angiogenesis extracellular matrix structural constituent conferring compression resistance extracellular matrix response to lipopolysaccharide wound healing positive regulation of transcription from RNA polymerase II promoter protein N-terminus binding positive regulation of mitochondrial depolarization positive regulation of mitochondrial fission negative regulation of vascular endothelial growth factor signaling pathway uc007gwx.1 uc007gwx.2 uc007gwx.3 uc007gwx.4 uc007gwx.5 
ENSMUST00000105290.9 Nr2c1 ENSMUST00000105290.9 nuclear receptor subfamily 2, group C, member 1 (from RefSeq NM_011629.3) ENSMUST00000105290.1 ENSMUST00000105290.2 ENSMUST00000105290.3 ENSMUST00000105290.4 ENSMUST00000105290.5 ENSMUST00000105290.6 ENSMUST00000105290.7 ENSMUST00000105290.8 NM_011629 NR2C1_MOUSE Nr2c1 P97763 Q0VGP8 Q3UIJ7 Q4U1Z4 Q505F1 Q60927 Q62152 Q8VIJ3 Tr2 Tr2-11 uc007gvo.1 uc007gvo.2 uc007gvo.3 uc007gvo.4 Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity). Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation. Homodimer. Heterodimer; with NR2C2 which is required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with ESR1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth (By similarity). Interacts with NRIP1 (via its LXXLL motifs); the interaction provides corepressor activity. Interacts with HDAC3 (via the DNA-binding domain); the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Interacts with HDAC4 (via the DNA-binding domain). Interacts with PIAS1; the interaction is required for sumoylation of NR2C1. Interacts with UBE2I; the interaction is required for sumoylation of NR2C1. Interacts with KAT2B; the interaction acts as a corepressor of gene expression. Q505F1; Q9JHD1: Kat2b; NbExp=3; IntAct=EBI-15617004, EBI-2325611; Q505F1; Q8CBD1: Nrip1; NbExp=3; IntAct=EBI-15617004, EBI-1771626; Q505F1; O88907: Pias1; NbExp=4; IntAct=EBI-15617004, EBI-3508327; Q505F1; Q60953: Pml; NbExp=2; IntAct=EBI-15617004, EBI-3895605; Q505F1; Q8BSJ6: Pml; NbExp=3; IntAct=EBI-15617004, EBI-15719975; Q505F1; P63166: Sumo1; NbExp=5; IntAct=EBI-15617004, EBI-80152; Q505F1; P63280: Ube2i; NbExp=3; IntAct=EBI-15617004, EBI-80180; Nucleus. Nucleus, PML body. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-210 phosphorylation, to PML bodies for subsequent sumoylation. Event=Alternative splicing; Named isoforms=2; Name=1 IsoId=Q505F1-1; Sequence=Displayed; Name=2 ; Synonyms=TR2-11-t , TR2-11-truncated ; IsoId=Q505F1-2; Sequence=VSP_051921, VSP_051922; Isoform 1 is highly expressed in the adlumenal compartment of the seminiferous tubule of adult testes (at protein level) and in the eyes of newborn animals. Weakly expressed in other adult organs including the seminal vesicle, prostate, ovary, adrenal gland, heart, thymus, placenta and brain. Expressed during embryonic stages in developing eyes, brain and cartilage primordia (at protein level). Also expressed in the developing spinal motor neurons and in the sympathetic-, parasympathetic- and sensory ganglia of the embryonic PNS. Expressed in the developing neural epithelia of the inner ear, nasal cavity, tongue and retina. At day 16.5, expressed in various tissues including kidney and intestine. In contrast, isoform 2 is widely expressed at a low level throughout the adult testis. Isoform 1 is highly expressed in early to midgestation embryos, with expression leveling off at 15 dpc. Expressed in yolk sac erythrocytes at 9.5 dpc. After birth, expression in the testes remains at a basal level until puberty, begins to increase at postnatal day 16 (P16) and peaks at P20 to P24. Expression is maintained at a high level throughout adulthood. Isoform 2 peaks transiently at P24. By ciliary neurotrophic factor (CNTF). Repressed by vitamin A. Induced by retinoic acid. Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression. Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-210, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-568 by PKC is important for protein stability and function as activator of RARB. No visible phenotype. Mice exhibit normal spermatogenesis and testis development, as well as normal central nervous system development. NR2C1 and NR2C2 double null mutants result in early embryonic lethality and increased apoptosis. Embryos die around 7.5 dpc. [Isoform 2]: Due to intron retention. Belongs to the nuclear hormone receptor family. NR2 subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity protein binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter zinc ion binding PML body cell differentiation protein homodimerization activity histone deacetylase binding steroid hormone mediated signaling pathway sequence-specific DNA binding negative regulation of transcription, DNA-templated metal ion binding positive regulation of retinoic acid receptor signaling pathway anatomical structure development uc007gvo.1 uc007gvo.2 uc007gvo.3 uc007gvo.4 
ENSMUST00000105306.3 Abtb3 ENSMUST00000105306.3 ankyrin repeat and BTB domain containing 3, transcript variant 2 (from RefSeq NM_001017525.1) Abtb3 Btbd11 E9QJW1 E9QJW1_MOUSE ENSMUST00000105306.1 ENSMUST00000105306.2 NM_001017525 uc007glh.1 uc007glh.2 uc007glh.3 uc007glh.1 uc007glh.2 uc007glh.3 
ENSMUST00000105322.9 Smim24 ENSMUST00000105322.9 small integral membrane protein 24 (from RefSeq NM_001099917.1) ENSMUST00000105322.1 ENSMUST00000105322.2 ENSMUST00000105322.3 ENSMUST00000105322.4 ENSMUST00000105322.5 ENSMUST00000105322.6 ENSMUST00000105322.7 ENSMUST00000105322.8 NM_001099917 Q0VG18 SIM24_MOUSE uc007ghw.1 uc007ghw.2 uc007ghw.3 Membrane ; Single-pass membrane protein molecular_function biological_process membrane integral component of membrane uc007ghw.1 uc007ghw.2 uc007ghw.3 
ENSMUST00000105323.8 Hmg20b ENSMUST00000105323.8 high mobility group 20B, transcript variant 3 (from RefSeq NM_001163166.1) Braf35 ENSMUST00000105323.1 ENSMUST00000105323.2 ENSMUST00000105323.3 ENSMUST00000105323.4 ENSMUST00000105323.5 ENSMUST00000105323.6 ENSMUST00000105323.7 HM20B_MOUSE Hmgx2 NM_001163166 Q9NSF7 Q9NSF8 Q9Z104 Smarce1r uc007ghn.1 uc007ghn.2 uc007ghn.3 uc007ghn.4 Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (By similarity). Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein (By similarity). Interacts with DTNB (PubMed:20530487). Q9Z104; P39428: Traf1; NbExp=3; IntAct=EBI-646920, EBI-520123; Nucleus Chromosome Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2. Widely expressed in adult tissues, particularly kidney, skin, testis and uterus. Highly expressed in embryonic tissues with high mitotic index, such as the proliferating ventricular zones of the fore-, mid- and hindbrain. four-way junction DNA binding BRCA2-BRAF35 complex DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm chromosome chromatin organization chromatin remodeling regulation of transcription, DNA-templated cell cycle nuclear body negative regulation of protein sumoylation skeletal muscle cell differentiation positive regulation of neuron differentiation protein heterodimerization activity condensed nuclear chromosome uc007ghn.1 uc007ghn.2 uc007ghn.3 uc007ghn.4 
ENSMUST00000105327.10 Pip5k1c ENSMUST00000105327.10 phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma, transcript variant 1 (from RefSeq NM_008844.3) ENSMUST00000105327.1 ENSMUST00000105327.2 ENSMUST00000105327.3 ENSMUST00000105327.4 ENSMUST00000105327.5 ENSMUST00000105327.6 ENSMUST00000105327.7 ENSMUST00000105327.8 ENSMUST00000105327.9 Kiaa0589 NM_008844 O70161 PI51C_MOUSE Pip5k1c Q505A1 Q80TW9 Q8VCU5 uc007ghc.1 uc007ghc.2 uc007ghc.3 uc007ghc.4 uc007ghc.5 Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:9535851, PubMed:14741049, PubMed:20622009, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (PubMed:19153220). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (PubMed:15386003). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (By similarity). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:16707488). Required for clathrin-coated pits assembly at the synapse (By similarity). Participates in cell junction assembly (By similarity). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (By similarity). Required for focal adhesion dynamics (PubMed:12422220). Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (By similarity). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (By similarity). Required for uropodium formation and retraction of the cell rear during directed migration (PubMed:17928408). Has a role in growth factor-stimulated directional cell migration and adhesion (PubMed:17635937). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed:17635937). Negative regulator of T-cell activation and adhesion (PubMed:20855869). Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T- cell receptor (PubMed:20855869). Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (PubMed:17609388, PubMed:20622009). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:14425, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.68; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14426; Evidence= Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero- 3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+); Xref=Rhea:RHEA:40363, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77136, ChEBI:CHEBI:77137, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40364; Evidence=; Reaction=1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D- myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl- sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+); Xref=Rhea:RHEA:40367, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77139, ChEBI:CHEBI:77140, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40368; Evidence=; Reaction=1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D- myo-inositol + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3- phospho-1D-myo-inositol 5-phosphate + ADP + H(+); Xref=Rhea:RHEA:40379, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77163, ChEBI:CHEBI:77164, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40380; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3- phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z,12Z)- octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+); Xref=Rhea:RHEA:40383, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77158, ChEBI:CHEBI:77159, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40384; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phospho-(1D-myo-inositol) + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+); Xref=Rhea:RHEA:40375, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77160, ChEBI:CHEBI:133606, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40376; Evidence=; Reaction=1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo- inositol + ATP = 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho- 1D-myo-inositol 5-phosphate + ADP + H(+); Xref=Rhea:RHEA:40387, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77165, ChEBI:CHEBI:77167, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40388; Evidence=; Activated by phosphatidic acid. Kinetic parameters: KM=37 uM for phosphatidylinositol-4-phosphate/PtdIns(4)P ; KM=39 uM for ATP ; KM=1.6 uM for 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phospho-1D-myo-inositol 4-phosphate ; KM=15 uM for 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho- 1D-myo-inositol 4-phosphate ; Isoform 1 interacts with TLN1 (PubMed:12422220, PubMed:14691141, PubMed:16707488). Interacts with TLN2; interaction stimulates 1-phosphatidylinositol-4-phosphate 5-kinase activity (By similarity). May compete with beta-integrins for the same binding site on TLN1 and TLN2. Interacts with ARF6 (By similarity). Interacts with AP2B1 (PubMed:19287005). Isoform 1 interacts with AP2M1; phosphorylation of PIP5K1C by CSK disrupts the interaction; clathrin competes with PIP5K1C (PubMed:16707488). Interacts with CDH1 (By similarity). Interacts with CSK. Interacts with PLCG1; interaction is abolished upon EGF stimulation (PubMed:17635937). Interacts with LAPTM4B; promotes SNX5 association with LAPTM4B; kinase activity of PIP5K1C is required; interaction is regulated by phosphatidylinositol 4,5-bisphosphate generated by PIP5K1C (By similarity). O70161; Q9DBG3-1: Ap2b1; NbExp=3; IntAct=EBI-773657, EBI-775239; O70161; Q9DBG3-2: Ap2b1; NbExp=8; IntAct=EBI-773657, EBI-7257021; Cell membrane; Peripheral membrane protein; Cytoplasmic side Endomembrane system Cytoplasm ll junction, focal adhesion Cell junction, adherens junction Cell projection, ruffle membrane Cell projection, phagocytic cup Cell projection, uropodium Note=During directional migration isoform 1 localized at the uropodium, and isoform 3 localized all along cell membrane including the uropodium and the leading edge. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=PIPKIgamma661; IsoId=O70161-1; Sequence=Displayed; Name=2; Synonyms=PIPKIgamma627; IsoId=O70161-2; Sequence=VSP_016013, VSP_016014; Name=3; Synonyms=PIPKIgamma635; IsoId=O70161-3; Sequence=VSP_016015; High expression in brain. Also detected in lung, thymus, heart, testicle, kidney and embryo. Highly expressed in forebrain, in particular in cerebellum, hippocampus and cerebral cortex. Expression increases during embryonic development and continued to steadily increase postnatally. Phosphorylation on Ser-645 negatively regulates binding to TLN2 and is strongly stimulated in mitosis. Phosphorylation on Tyr-644 is necessary for targeting to focal adhesions. Phosphorylation on Ser-645 and Tyr-644 are mutually exclusive. Phosphorylated by SYK and CSK. Tyrosine phosphorylation is enhanced by PTK2 signaling. Phosphorylated at Tyr-634 upon EGF stimulation. Some studies suggest that phosphorylation on Tyr-644 enhances binding to tailins (TLN1 and TLN2); others that phosphorylation at Tyr-644 does not directly enhance binding to tailins (TLN1 and TLN2) but may act indirectly by inhibiting phosphorylation at Ser-645. Acetylation at Lys-265 and Lys-268 seems to decrease lipid kinase activity. Deacetylation of these sites by SIRT1 positively regulates the exocytosis of TSH-containing granules from pituitary cells (By similarity). According to some authors, mutants die within hours after birth and are unable to feed after birth (PubMed:15386003). According to another report, mutants are embryonically lethal at organogenesis stage, and display cardiovascular and neuronal defects (PubMed:15386003). PIP5K1C and PIP5K1B double mutant mice die within minutes after birth. PIP5K1C and PIP5K1A double mutant mice are embryonic lethal. Bone marrow-derived macrophages are defective in phagocytosis, attachment to IgG-opsonized particles and Fc-gamma-R clustering, and display highly polymerized actin cytoskeleton. Neurons display defects in synaptic transmission due to defects in synaptic vesicle trafficking at different levels. T-cells mutant for isoform 1 display increase adhesion and polarization. Sequence=BAC65601.2; Type=Erroneous initiation; Evidence=; nucleotide binding phagocytic cup uropod protein binding ATP binding nucleoplasm cytoplasm cytosol plasma membrane adherens junction focal adhesion phosphatidylinositol biosynthetic process exocytosis endocytosis phagocytosis chemotaxis cytoskeletal anchoring at plasma membrane cell adhesion axonogenesis endosome membrane endomembrane system postsynaptic density membrane kinase activity phosphatidylinositol phosphate kinase activity 1-phosphatidylinositol-4-phosphate 5-kinase activity phosphorylation transferase activity cell junction ruffle membrane cell projection phosphatidylinositol metabolic process phosphatidylinositol phosphorylation platelet aggregation presynaptic endocytic zone membrane glutamatergic synapse regulation of synaptic vesicle endocytosis talin binding uc007ghc.1 uc007ghc.2 uc007ghc.3 uc007ghc.4 uc007ghc.5 
ENSMUST00000105331.8 Map2k2 ENSMUST00000105331.8 mitogen-activated protein kinase kinase 2, transcript variant 3 (from RefSeq NM_001358539.1) ENSMUST00000105331.1 ENSMUST00000105331.2 ENSMUST00000105331.3 ENSMUST00000105331.4 ENSMUST00000105331.5 ENSMUST00000105331.6 ENSMUST00000105331.7 Map2k2 NM_001358539 Q91YS7 Q91YS7_MOUSE uc007gfy.1 uc007gfy.2 uc007gfy.3 uc007gfy.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation kinase activity phosphorylation uc007gfy.1 uc007gfy.2 uc007gfy.3 uc007gfy.4 
ENSMUST00000105336.9 Dot1l ENSMUST00000105336.9 DOT1 like histone lysine methyltransferase (from RefSeq NM_199322.2) Dot1l ENSMUST00000105336.1 ENSMUST00000105336.2 ENSMUST00000105336.3 ENSMUST00000105336.4 ENSMUST00000105336.5 ENSMUST00000105336.6 ENSMUST00000105336.7 ENSMUST00000105336.8 NM_199322 Q6XZL8 Q6XZL8_MOUSE uc007gel.1 uc007gel.2 uc007gel.3 Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. Histone methyltransferase. Methylates 'Lys-79' of histone H3. Reaction=L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60328, Rhea:RHEA-COMP:15549, Rhea:RHEA- COMP:15552, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.360; Evidence= Nucleus In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones. Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. DNA damage checkpoint chromosome, telomeric region nucleus nucleoplasm chromatin organization chromatin silencing chromatin silencing at telomere transcription factor binding methyltransferase activity positive regulation of cell proliferation transferase activity histone-lysine N-methyltransferase activity histone methyltransferase activity (H3-K79 specific) methylation macromolecular complex histone H3-K79 methylation histone methyltransferase activity intracellular membrane-bounded organelle positive regulation of transcription from RNA polymerase II promoter regulation of JAK-STAT cascade regulation of cell cycle regulation of transcription regulatory region DNA binding uc007gel.1 uc007gel.2 uc007gel.3 
ENSMUST00000105346.10 Tcf3 ENSMUST00000105346.10 transcription factor 3, transcript variant 13 (from RefSeq NM_001378910.1) Alf2 ENSMUST00000105346.1 ENSMUST00000105346.2 ENSMUST00000105346.3 ENSMUST00000105346.4 ENSMUST00000105346.5 ENSMUST00000105346.6 ENSMUST00000105346.7 ENSMUST00000105346.8 ENSMUST00000105346.9 Me2 NM_001378910 P15806 Q3U153 Q8CAH9 Q8VCY4 Q922S2 Q99MB8 Q9CYJ4 TFE2_MOUSE Tcfe2a uc007gdi.1 uc007gdi.2 uc007gdi.3 uc007gdi.4 Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (PubMed:15226298, PubMed:18214987). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (PubMed:18214987). Together with TCF15, required for the mesenchymal to epithelial transition (PubMed:11309385, PubMed:15226298). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (PubMed:15226298, PubMed:18214987, PubMed:30426815). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (PubMed:2181401). [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. Homodimer (PubMed:12196028). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (PubMed:15226298). Forms a heterodimer with TWIST1 and TWIST2 (PubMed:7589808, PubMed:23395635). Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E- box element (PubMed:23395635, PubMed:18069799). Forms a heterodimer with TCF15; the heterodimer binds E-box element (PubMed:15226298, PubMed:23395635). Forms a heterodimer with MYOG; heterodimerization enhances MYOG DNA-binding and transcriptional activities (PubMed:12196028). Forms a heterodimer with ATOH8; repress transcription of TCF3 and TCF3-NEUROG3 dimer-induced transactivation of E box-dependent promoters (PubMed:23938248). Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (PubMed:16407974). Interacts with NEUROD2 (PubMed:18214987). Interacts with EP300 (By similarity). Interacts with PTF1A, TGFB1I1 and UBE2I (PubMed:9409784, PubMed:11318877, PubMed:16291758). Interacts with BHLHA9 (By similarity). Interacts with ASB2; the interaction is mediated by SKP2 and targets TCF3 for Notch-induced proteasomal degradation (By similarity). Interacts with transcription factor ASCL5/AmeloD. [Isoform E47]: Forms a heterodimer with ATOH7; required for ATOH7 DNA-binding. [Isoform E12]: Interacts with RALGAPA1 (PubMed:12200424). Interacts with FIGLA (By similarity). P15806; Q64279: Hand1; NbExp=2; IntAct=EBI-81370, EBI-81361; P15806; Q61039: Hand2; NbExp=2; IntAct=EBI-81370, EBI-81388; P15806; P41136: Id2; NbExp=2; IntAct=EBI-81370, EBI-309167; P15806; P22091: Tal1; NbExp=4; IntAct=EBI-81370, EBI-8006437; P15806-2; P41136: Id2; NbExp=6; IntAct=EBI-413585, EBI-309167; Nucleus Event=Alternative splicing; Named isoforms=2; Name=E12; IsoId=P15806-1; Sequence=Displayed; Name=E47; IsoId=P15806-2; Sequence=VSP_011354; Expressed during the development of the nervous system. Phosphorylated following NGF stimulation. Undergoes Notch-induced ubiquitination and subsequent proteasomal degradation which is mediated by ASB1 or ASB2, the substrate- recognition components of probable ECS E3 ubiquitin-protein ligase complexes. Mice are smaller than their wild-type littermates and fail to thrive 14 days after birth. negative regulation of transcription from RNA polymerase II promoter nuclear nucleosome nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding natural killer cell differentiation B cell lineage commitment DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus nucleoplasm transcription factor complex cytoplasm transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter gastrulation nervous system development transcription factor binding positive regulation of gene expression nuclear speck lymphocyte differentiation cell differentiation PDZ domain binding erythrocyte differentiation positive regulation of B cell proliferation mitogen-activated protein kinase kinase kinase binding response to lipopolysaccharide macromolecular complex T cell differentiation in thymus immunoglobulin V(D)J recombination response to drug protein homodimerization activity bHLH transcription factor binding sequence-specific DNA binding histone H3 acetylation histone H4 acetylation negative regulation of erythrocyte differentiation positive regulation of neuron differentiation positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity cell development Peyer's patch development protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of protein tyrosine kinase activity repressing transcription factor binding vitamin D response element binding E-box binding RNA polymerase II transcription factor complex regulation of G1/S transition of mitotic cell cycle positive regulation of receptor activity transcription regulatory region DNA binding uc007gdi.1 uc007gdi.2 uc007gdi.3 uc007gdi.4 
ENSMUST00000105350.3 Mex3d ENSMUST00000105350.3 mex3 RNA binding family member D (from RefSeq NM_198615.2) D3YTR3 D3YTR3_MOUSE E9PUA0 ENSMUST00000105350.1 ENSMUST00000105350.2 Mex3d NM_198615 uc007gcz.1 uc007gcz.2 uc007gcz.3 Cytoplasm Nucleus nucleic acid binding RNA binding nucleus mRNA 3'-UTR AU-rich region binding perinuclear region of cytoplasm uc007gcz.1 uc007gcz.2 uc007gcz.3 
ENSMUST00000105351.2 Plk5 ENSMUST00000105351.2 polo like kinase 5, transcript variant 2 (from RefSeq NM_001347124.1) ENSMUST00000105351.1 NM_001347124 PLK5_MOUSE Plk5 Q0VGS4 Q4FZD7 Q8C096 uc007gcy.1 uc007gcy.2 uc007gcy.3 Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation. Nucleus, nucleolus Cytoplasm Expressed in the cerebellum, eye and brain cortex (at protein level). Expressed in highly differentiated tissues, such as brain, eyes and ovary. Not detectable in proliferating tissues, such as the colon, spleen and placenta. Down-regulated in proliferating cells or in serum-stimulated cells or growth factors. Up-regulated in asynchronous cells, or upon serum deprivation or following stress inducible DNA damage treatment. The protein kinase domain is predicted to be catalytically inactive; has lost the main activatory autophosphorylation site and the conserved key residues involved in phospho-substrate. The C-terminal region (containing the POLO box domain) is sufficient for inducing cell cycle arrest (By similarity). Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. Sequence=AAH86684.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC27628.1; Type=Frameshift; Evidence=; nucleotide binding mitotic cell cycle spindle pole defense response to tumor cell ATP binding nucleus nucleolus cytoplasm centrosome protein phosphorylation cellular response to DNA damage stimulus cell cycle negative regulation of cell proliferation positive regulation of neuron projection development cell differentiation regulation of cytokinesis regulation of apoptotic process metal ion binding cell division cellular response to growth factor stimulus regulation of G1/S transition of mitotic cell cycle kinase activity uc007gcy.1 uc007gcy.2 uc007gcy.3 
ENSMUST00000105354.8 Reep6 ENSMUST00000105354.8 Required for correct function and survival of retinal photoreceptors (PubMed:24098485, PubMed:24691551, PubMed:28475715). Required for retinal development (PubMed:28369466). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (PubMed:28475715). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (PubMed:24098485, PubMed:28369466). (from UniProt Q9JM62) AB039933 Dp1l1 ENSMUST00000105354.1 ENSMUST00000105354.2 ENSMUST00000105354.3 ENSMUST00000105354.4 ENSMUST00000105354.5 ENSMUST00000105354.6 ENSMUST00000105354.7 Q8K0X2 Q9JM62 REEP6_MOUSE Tb2l1 uc007gct.1 uc007gct.2 uc007gct.3 uc007gct.4 Required for correct function and survival of retinal photoreceptors (PubMed:24098485, PubMed:24691551, PubMed:28475715). Required for retinal development (PubMed:28369466). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (PubMed:28475715). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (PubMed:24098485, PubMed:28369466). Interacts with STX3 (PubMed:28369466). Interacts with clathrin (PubMed:28369466). Endoplasmic reticulum membrane ; Multi-pass membrane protein Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JM62-1; Sequence=Displayed; Name=2; IsoId=Q9JM62-2; Sequence=VSP_016631, VSP_016632; Expressed in the inner segment of rod photoreceptors and outer plexiform layer of the retina (at protein level) (PubMed:24691551, PubMed:28369466, PubMed:28475715). Expressed in liver, but not detected in brain, muscle, kidney, retinal cone photoreceptors or retinal ganglion cells (at protein level) (PubMed:24691551). Highly expressed in the ganglion cell layer of the retina and in liver, and also detected at low levels in kidney and testis (PubMed:15728532). Isoform 1: Expressed in the retina (PubMed:15728532, PubMed:24691551). Isoform 2: Expressed in liver (PubMed:24691551). Isoform 1 shows increasing levels of expression in the retina from birth, reaching maximal levels by 12 days of age. Viable, however mice develop progressive deterioration in retinal response, and male mice are sterile (PubMed:28369466, PubMed:28475715). Progressive retinal rod dysfunction first evident from one month of age progressing to almost undetectable scotopic response at one year of age (PubMed:28369466). Progressive degeneration of photopic response by retinal cone receptors first evident at one year of age (PubMed:28369466). Defective retinal morphology with significant thinning of the outer nuclear layer and reduced rows of nuclei (PubMed:28369466, PubMed:28475715). Accumulation of vacuole-like structures at the apical inner segment of the retina (PubMed:28369466). Reduced and disorganised photoreceptors with shortened fragmented outer segment (PubMed:28475715). Altered endoplasmic reticulum (ER) organization with increased ER area near the base of the outer segment, increased number of mitochondria in the rod ellipsoid region and induction of ER stress (PubMed:28475715). Reduced retinal expression of phototransduction proteins Cngb1 and Gnat1 and of Aipl1 (PubMed:28369466). Reduced expression of guanylate cyclases Gucy2e/GC1 and Gucy2f/GC2 in the rod outer segment and mislocalization of Pde6a from the outer segment to the inner segment and outer nuclear layer (PubMed:28475715). Belongs to the DP1 family. photoreceptor inner segment protein binding endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane clathrin-coated vesicle membrane cytoplasmic vesicle regulation of intracellular transport rod spherule apical part of cell detection of light stimulus involved in visual perception plasma membrane uc007gct.1 uc007gct.2 uc007gct.3 uc007gct.4 
ENSMUST00000105359.8 Apc2 ENSMUST00000105359.8 APC regulator of WNT signaling pathway 2, transcript variant 3 (from RefSeq NM_001372238.1) Apc2 D3YTR0 D3YTR0_MOUSE ENSMUST00000105359.1 ENSMUST00000105359.2 ENSMUST00000105359.3 ENSMUST00000105359.4 ENSMUST00000105359.5 ENSMUST00000105359.6 ENSMUST00000105359.7 NM_001372238 uc287syz.1 uc287syz.2 Belongs to the adenomatous polyposis coli (APC) family. beta-catenin binding microtubule binding Wnt signaling pathway negative regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway uc287syz.1 uc287syz.2 
ENSMUST00000105362.8 Dazap1 ENSMUST00000105362.8 DAZ associated protein 1, transcript variant 10 (from RefSeq NR_166401.1) DAZP1_MOUSE ENSMUST00000105362.1 ENSMUST00000105362.2 ENSMUST00000105362.3 ENSMUST00000105362.4 ENSMUST00000105362.5 ENSMUST00000105362.6 ENSMUST00000105362.7 NR_166401 Q9JII5 uc007gcl.1 uc007gcl.2 uc007gcl.3 uc007gcl.4 RNA-binding protein, which may be required during spermatogenesis. Interacts with DAZ and DAZL. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoides development. In midpachytene spermatocytes, it is localized in both the cytoplasm and the nuclei and is clearly excluded from the sex vesicles. In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JII5-1; Sequence=Displayed; Name=2; IsoId=Q9JII5-2; Sequence=VSP_009443; Mainly expressed in testis. Expressed at much lower level in liver, heart and brain. Also expressed in ovary. Expressed throughout testes development, in both the prenatal and postnatal periods. First expressed in midpachytene spermatocytes in stage VII tubules. Acetylation at Lys-150 is predominantly observed in the nuclear fraction, and may regulate nucleocytoplasmic transport. maternal placenta development nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding nucleus nucleoplasm cytoplasm cytosol multicellular organism development spermatogenesis poly(U) RNA binding cell proliferation cell differentiation macromolecular complex poly(G) binding RNA stem-loop binding positive regulation of mRNA splicing, via spliceosome ribonucleoprotein complex polysome uc007gcl.1 uc007gcl.2 uc007gcl.3 uc007gcl.4 
ENSMUST00000105363.8 Gamt ENSMUST00000105363.8 guanidinoacetate methyltransferase, transcript variant 1 (from RefSeq NM_010255.4) ENSMUST00000105363.1 ENSMUST00000105363.2 ENSMUST00000105363.3 ENSMUST00000105363.4 ENSMUST00000105363.5 ENSMUST00000105363.6 ENSMUST00000105363.7 GAMT_MOUSE NM_010255 O35969 Q3TZ58 Q3US90 uc007gcj.1 uc007gcj.2 uc007gcj.3 uc007gcj.4 Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development. Reaction=guanidinoacetate + S-adenosyl-L-methionine = creatine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:10656, ChEBI:CHEBI:15378, ChEBI:CHEBI:57742, ChEBI:CHEBI:57856, ChEBI:CHEBI:57947, ChEBI:CHEBI:59789; EC=2.1.1.2; Evidence= Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2. Monomer. Cell projection, microvillus Note=Detected in microvilli of the epithelial cells lining the caput epididymis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O35969-1; Sequence=Displayed; Name=2; IsoId=O35969-2; Sequence=VSP_017727; Highly expressed in testis, caput epididymis, ovary, and liver. In the testis, localized primarily in Sertoli cells. Expressed in brain with high levels in oligodendrocytes and olfactory ensheathing glia. Moderate levels of expression in astrocytes. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. nucleus cytoplasm cytosol microvillus creatine biosynthetic process spermatogenesis methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity animal organ morphogenesis transferase activity guanidinoacetate N-methyltransferase activity methylation regulation of multicellular organism growth protein homodimerization activity cell projection S-adenosylhomocysteine metabolic process S-adenosylmethionine metabolic process uc007gcj.1 uc007gcj.2 uc007gcj.3 uc007gcj.4 
ENSMUST00000105364.8 Ndufs7 ENSMUST00000105364.8 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I. (from UniProt Q9DC70) AK003132 ENSMUST00000105364.1 ENSMUST00000105364.2 ENSMUST00000105364.3 ENSMUST00000105364.4 ENSMUST00000105364.5 ENSMUST00000105364.6 ENSMUST00000105364.7 NDUS7_MOUSE Q9DC70 uc287sym.1 uc287sym.2 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I. Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Hydroxylated ar Arg-111 by NDUFAF5 early in the pathway of assembly of complex I, before the formation of the juncture between peripheral and membrane arms. Belongs to the complex I 20 kDa subunit family. protease binding NADH dehydrogenase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I NADH dehydrogenase (ubiquinone) activity aerobic respiration electron transport coupled proton transport oxidoreductase activity mitochondrial respiratory chain complex I assembly neuron projection neuronal cell body metal ion binding quinone binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding oxidation-reduction process respiratory chain synaptic membrane uc287sym.1 uc287sym.2 
ENSMUST00000105365.9 Cirbp ENSMUST00000105365.9 cold inducible RNA binding protein, transcript variant 1 (from RefSeq NM_007705.3) CIRBP_MOUSE Cirp ENSMUST00000105365.1 ENSMUST00000105365.2 ENSMUST00000105365.3 ENSMUST00000105365.4 ENSMUST00000105365.5 ENSMUST00000105365.6 ENSMUST00000105365.7 ENSMUST00000105365.8 NM_007705 O09069 O09148 P60824 Q3V1A6 Q61413 uc007gce.1 uc007gce.2 uc007gce.3 Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpressed. Seems to play an essential role in cold- induced suppression of cell proliferation. Acts as a translational repressor. Acts as a translational activator. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Interacts with EIF4G1. Associates with ribosomes (By similarity). Nucleus, nucleoplasm Cytoplasm Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation (By similarity). Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins. Ubiquitous. Up-regulated upon mild cold-shock and hypoxia. Both the RRM domain and the arginine, glycine (RGG) rich domain are necessary for binding to the TXN 3'-untranslated region (By similarity). Both the RRM domain and the arginine, glycine (RGG) rich domain (RGG repeats) are necessary for optimal recruitment into SGs upon cellular stress. The C-terminal domain containing RGG repeats is necessary for translational repression. Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs. Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation (By similarity). nucleic acid binding RNA binding mRNA 3'-UTR binding nucleus nucleoplasm spliceosomal complex nucleolus cytoplasm poly(U) RNA binding response to cold response to UV cytoplasmic stress granule negative regulation of translation negative regulation of cell growth translation repressor activity stress granule assembly positive regulation of translation positive regulation of mRNA splicing, via spliceosome mRNA stabilization small ribosomal subunit rRNA binding cellular response to cold regulation of cell cycle G1/S phase transition ribonucleoprotein complex uc007gce.1 uc007gce.2 uc007gce.3 
ENSMUST00000105367.8 Atp5f1d ENSMUST00000105367.8 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. (from UniProt Q9D3D9) AK155285 ATPD_MOUSE Atp5d Atp5f1d ENSMUST00000105367.1 ENSMUST00000105367.2 ENSMUST00000105367.3 ENSMUST00000105367.4 ENSMUST00000105367.5 ENSMUST00000105367.6 ENSMUST00000105367.7 Q9D3D9 uc287sxq.1 uc287sxq.2 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). Mitochondrion. Mitochondrion inner membrane. Belongs to the ATPase epsilon chain family. mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) mitochondrion mitochondrial envelope mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex ATP biosynthetic process ion transport aerobic respiration hydrogen ion transmembrane transporter activity ATP synthesis coupled proton transport membrane ATPase activity mitochondrial proton-transporting ATP synthase complex assembly macromolecular complex binding proton-transporting ATP synthase complex proton-transporting ATP synthase complex, catalytic core F(1) ATP metabolic process proton-transporting ATP synthase activity, rotational mechanism hydrogen ion transmembrane transport uc287sxq.1 uc287sxq.2 
ENSMUST00000105369.8 Cbarp ENSMUST00000105369.8 calcium channel, voltage-dependent, beta subunit associated regulatory protein, transcript variant 7 (from RefSeq NM_001421401.1) Barp CBARP_MOUSE Cbarp Dos E9QP85 ENSMUST00000105369.1 ENSMUST00000105369.2 ENSMUST00000105369.3 ENSMUST00000105369.4 ENSMUST00000105369.5 ENSMUST00000105369.6 ENSMUST00000105369.7 NM_001421401 Q497H6 Q66L44 Q8CBL1 Q9QZY3 R29144/1 uc287sxc.1 uc287sxc.2 Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. Interacts with voltage-dependent calcium channels CACNB1, CACNB2, CACNB3 and CACNB4 beta subunits; prevents their interaction with the CACNA1C alpha subunit thereby negatively regulating the activity of the corresponding calcium channels. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type III membrane protein Cell membrane ; Single-pass type III membrane protein Cell projection, growth cone Expressed by neurons in the cortex, cerebellum and hippocampus and by pancreatic beta cells (at protein level). Detected in brain from 14 dpc until adulthood with higher expression between 18 dpc and P7 (at protein level). Sequence=AAI00553.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; plasma membrane membrane integral component of membrane cell junction secretory granule growth cone synaptic vesicle membrane cytoplasmic vesicle cell projection ion channel binding synapse negative regulation of calcium ion-dependent exocytosis negative regulation of voltage-gated calcium channel activity negative regulation of calcium ion transmembrane transport uc287sxc.1 uc287sxc.2 
ENSMUST00000105372.9 Gpx4 ENSMUST00000105372.9 glutathione peroxidase 4, transcript variant 1 (from RefSeq NM_008162.4) ENSMUST00000105372.1 ENSMUST00000105372.2 ENSMUST00000105372.3 ENSMUST00000105372.4 ENSMUST00000105372.5 ENSMUST00000105372.6 ENSMUST00000105372.7 ENSMUST00000105372.8 GPX4_MOUSE Gpx4 NM_008162 O35560 O70325 Q8K4U8 Q91XR9 Q9JK35 uc007gbk.1 uc007gbk.2 uc007gbk.3 The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Disruption of this gene in mouse spermatocytes is associated with male infertility. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. Pseudogenes of this locus have been identified on chromosomes 10 and 17. [provided by RefSeq, Jan 2019]. Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (PubMed:29290465). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (PubMed:12566075). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed:12566075, PubMed:24439385, PubMed:25402683, PubMed:25922076, PubMed:29290465). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (PubMed:29290465). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (PubMed:29290465). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (PubMed:12566075). Required for normal sperm development and male fertility (PubMed:19783653, PubMed:25922076). Essential for maturation and survival of photoreceptor cells (PubMed:22207760). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (PubMed:25824823). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down- regulator of the cellular 15-lipoxygenase pathway (By similarity). Can also reduce small soluble hydroperoxides such as H2O2 and tert-butyl hydroperoxide (PubMed:12566075). [Isoform Cytoplasmic]: Specifically able to suppress the production of leukotriene and prostaglandin in response to several stimuli by reducing fatty acid hydroperoxide. [Isoform Mitochondrial]: Specifically required to prevent mitochondrial cell death by mediating reduction of cardiolipin hydroperoxide (By similarity). Also required for normal sperm development and male fertility (PubMed:19417079). [Isoform Nuclear]: Required for male fertility by stabilizing the condensed chromatin in sperm nuclei (PubMed:12566075). Reaction=a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O; Xref=Rhea:RHEA:19057, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:131871, ChEBI:CHEBI:134019; EC=1.11.1.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19058; Evidence=; Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16834; Evidence=; Reaction=2 glutathione + tert-butyl hydroperoxide = glutathione disulfide + H2O + tert-butanol; Xref=Rhea:RHEA:69412, ChEBI:CHEBI:15377, ChEBI:CHEBI:45895, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:64090; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69413; Evidence=; Reaction=cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O; Xref=Rhea:RHEA:69651, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:78673, ChEBI:CHEBI:131607; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69652; Evidence=; Reaction=(9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76687, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:60955, ChEBI:CHEBI:77852; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76688; Evidence=; Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48888, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90850; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48889; Evidence=; Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48620, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90632; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48621; Evidence=; Reaction=(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76691, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:75230, ChEBI:CHEBI:83343; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76692; Evidence=; Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:50708, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90680; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50709; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76695, ChEBI:CHEBI:15377, ChEBI:CHEBI:57409, ChEBI:CHEBI:57446, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76696; Evidence=; Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76699, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:195399, ChEBI:CHEBI:195400; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76700; Evidence=; Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76703, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90772, ChEBI:CHEBI:195401; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76704; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76707, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:132087, ChEBI:CHEBI:194369; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76708; Evidence=; Reaction=(15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76711, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:144832, ChEBI:CHEBI:195402; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76712; Evidence=; Reaction=(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:76715, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:133795, ChEBI:CHEBI:195403; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76716; Evidence=; Reaction=a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O; Xref=Rhea:RHEA:76731, ChEBI:CHEBI:15377, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:195423, ChEBI:CHEBI:195424; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76732; Evidence=; Monomer. Has a tendency to form higher mass oligomers. [Isoform Mitochondrial]: Mitochondrion [Isoform Cytoplasmic]: Cytoplasm [Isoform Nuclear]: Nucleus Event=Alternative splicing, Alternative initiation; Named isoforms=3; Name=Mitochondrial; Synonyms=mGPx4 ; IsoId=O70325-1; Sequence=Displayed; Name=Cytoplasmic; Synonyms=cGPx4 ; IsoId=O70325-2; Sequence=VSP_018743; Name=Nuclear; Synonyms=nGPx4 ; IsoId=O70325-3; Sequence=VSP_059349; Widely expressed with the highest levels in testis, heart, cerebrum, ileum, stomach, liver, jejunum and epididymis (PubMed:17503194). Expressed primarily in testis and sperm midpiece (at protein level) (PubMed:19417079, PubMed:12566075). Expressed in brain (at protein level) (PubMed:22207760, PubMed:12566075). Expressed in heart, liver and kidney (at protein level) (PubMed:12566075). Expressed in retina, especially in inner segments of photoreceptor cells (at protein level) (PubMed:22207760). [Isoform Mitochondrial]: Highly expressed during embryogenesis (PubMed:1668477). Down-regulated between 14.5 dpc and 17.5 dpc (PubMed:1668477). [Isoform Cytoplasmic]: Highly expressed during embryogenesis (PubMed:1668477). In contrast to isoform Mitochondrial and isoform Nuclear, which are down-regulated between 14.5 dpc and 17.5 dpc, remains constant (PubMed:1668477). [Isoform Nuclear]: Mainly expressed in sperm (PubMed:11344099). Weakly expressed during embryogenesis (PubMed:1668477). Down-regulated between 14.5 dpc and 17.5 dpc (PubMed:1668477). Embryonic lethality in utero at midgestation, caused by inability to initiate gastrulation and the absence of embryonic cavities (PubMed:12745070). Conditional knockout mice lacking Gpx4 in spermatocytes causes sperm abnormalities and male infertility (PubMed:19783653). Conditional knockout mice lacking Gpx4 in photoreceptor cells causes retinal degeneration, decreased mitochondrial biomass and decreased number of connecting cilia in these cells (PubMed:22207760). Mice display neurodegeneration (PubMed:18762024). Conditional knockout mice lacking Gpx4 in neurons show reduced parvalbumin-positive interneurons and develop phenotypes, such as cerebellar hypoplasia and seizures (PubMed:19890015, PubMed:24599700). Induced disruption of Gpx4 in mice causes acute renal failure and early death due to ferroptosis (PubMed:25402683). [Isoform Mitochondrial]: Isoform mitochondrial: Selective disruption of isoform mitochondrial causes sperm abnormalities and male infertility (PubMed:19417079). The presence of selenolate in the active site is essential for resistance to overoxidation: in the absence of reducing equivalents, the enzyme can form a selenylamide intermediate during its catalytic cycle, thereby preventing its irreversible overoxidation. [Isoform Cytoplasmic]: Produced by alternative initiation at Met-28 of isoform Mitochondrial. Belongs to the glutathione peroxidase family. Name=Protein Spotlight; Note=Life, a subtle balance - Issue 205 of July 2018; URL="https://web.expasy.org/spotlight/back_issues/205/"; peroxidase activity glutathione peroxidase activity nucleus nuclear envelope nucleoplasm cytoplasm mitochondrion mitochondrial inner membrane cytosol chromatin organization glutathione metabolic process response to oxidative stress multicellular organism development spermatogenesis aging selenium binding oxidoreductase activity response to estradiol macromolecular complex identical protein binding phospholipid-hydroperoxide glutathione peroxidase activity regulation of inflammatory response protein polymerization oxidation-reduction process cellular oxidant detoxification uc007gbk.1 uc007gbk.2 uc007gbk.3 
ENSMUST00000105378.9 Med16 ENSMUST00000105378.9 mediator complex subunit 16, transcript variant 1 (from RefSeq NM_198107.3) E9QM81 ENSMUST00000105378.1 ENSMUST00000105378.2 ENSMUST00000105378.3 ENSMUST00000105378.4 ENSMUST00000105378.5 ENSMUST00000105378.6 ENSMUST00000105378.7 ENSMUST00000105378.8 MED16_MOUSE NM_198107 Q6PGF3 Thrap5 uc007gal.1 uc007gal.2 uc007gal.3 uc007gal.4 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Nucleus Belongs to the Mediator complex subunit 16 family. transcription cofactor activity catalytic activity nucleus nucleoplasm transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter mediator complex thyroid hormone receptor coactivator activity positive regulation of transcription, DNA-templated thyroid hormone receptor binding uc007gal.1 uc007gal.2 uc007gal.3 uc007gal.4 
ENSMUST00000105383.4 Tektl1 ENSMUST00000105383.4 tektin like 1 (from RefSeq NM_027630.1) Ccdc105 ENSMUST00000105383.1 ENSMUST00000105383.2 ENSMUST00000105383.3 G3X9S0 NM_027630 Q9D4K7 TEKL1_MOUSE Tektl1 uc007fyf.1 uc007fyf.2 uc007fyf.3 uc007fyf.4 Sequence=BAB30245.1; Type=Frameshift; Evidence=; molecular_function biological_process uc007fyf.1 uc007fyf.2 uc007fyf.3 uc007fyf.4 
ENSMUST00000105384.5 Ilvbl ENSMUST00000105384.5 ilvB (bacterial acetolactate synthase)-like, transcript variant 2 (from RefSeq NM_173751.4) ENSMUST00000105384.1 ENSMUST00000105384.2 ENSMUST00000105384.3 ENSMUST00000105384.4 HACL2_MOUSE Hacl2 NM_173751 Q3UNZ4 Q3UZY5 Q8BU33 uc007fxv.1 uc007fxv.2 uc007fxv.3 Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. Reaction=2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal; Xref=Rhea:RHEA:55196, ChEBI:CHEBI:57376, ChEBI:CHEBI:74116, ChEBI:CHEBI:138631; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55197; Evidence=; Reaction=(2R)-hydroxyhexadecanoyl-CoA = formyl-CoA + pentadecanal; Xref=Rhea:RHEA:55212, ChEBI:CHEBI:17302, ChEBI:CHEBI:57376, ChEBI:CHEBI:138654; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55213; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Note=Binds 1 thiamine pyrophosphate per subunit. ; Endoplasmic reticulum membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BU33-1; Sequence=Displayed; Name=2; IsoId=Q8BU33-2; Sequence=VSP_030393, VSP_030395; Name=3; IsoId=Q8BU33-3; Sequence=VSP_030392, VSP_030394; Belongs to the TPP enzyme family. magnesium ion binding catalytic activity biological_process membrane integral component of membrane transferase activity thiamine pyrophosphate binding metal ion binding uc007fxv.1 uc007fxv.2 uc007fxv.3 
ENSMUST00000105393.3 Icosl ENSMUST00000105393.3 icos ligand (from RefSeq NM_015790.3) B7h2 B7rp1 ENSMUST00000105393.1 ENSMUST00000105393.2 ICOSL_MOUSE Icoslg NM_015790 Q9JHJ8 uc007fxi.1 uc007fxi.2 uc007fxi.3 Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype. Interacts with CTLA4 (in vitro). Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9JHJ8-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9JHJ8-2; Sequence=VSP_002521; Isoform 1 highest expression in lymphoid tissues, such as spleen (mostly in the marginal zone), lymph nodes (particularly in the cortex and in both primary and secondary follicles), thymus (predominantly in the medulla) and Peyer patches (mostly in the follicles), lower levels in many non-lymphoid tissues, such as brain, heart, kidney, liver, lung, skeletal muscle and testis. Present on freshly isolated splenic B-cells, T-cells, dendritic cells and macrophages. The expression of isoform 2 is restricted to heart, spleen and kidney. Detected early in hemopoiesis: in the yolk sac at 11.5 and 12.5 dpc and, to a lesser extent, in the liver at 14.5 dpc. Belongs to the immunoglobulin superfamily. BTN/MOG family. adaptive immune response immune system process receptor binding protein binding plasma membrane integral component of plasma membrane signal transduction external side of plasma membrane membrane integral component of membrane cytoplasmic ribonucleoprotein granule positive regulation of activated T cell proliferation T cell activation B cell activation identical protein binding isotype switching positive regulation of interleukin-4 biosynthetic process regulation of immune response T cell receptor signaling pathway uc007fxi.1 uc007fxi.2 uc007fxi.3 
ENSMUST00000105397.10 Cfap410 ENSMUST00000105397.10 cilia and flagella associated protein 410 (from RefSeq NM_026431.2) CF410_MOUSE Cfap410 ENSMUST00000105397.1 ENSMUST00000105397.2 ENSMUST00000105397.3 ENSMUST00000105397.4 ENSMUST00000105397.5 ENSMUST00000105397.6 ENSMUST00000105397.7 ENSMUST00000105397.8 ENSMUST00000105397.9 NM_026431 Q8C6G1 Q91Z02 uc007fwn.1 uc007fwn.2 uc007fwn.3 Plays a role in cilia formation and/or maintenance (PubMed:21289087). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Involved in DNA damage repair (By similarity). Found in a complex with CFAP410, NEK1 and SPATA7 (By similarity). Interacts with NEK1 (By similarity). Cell projection, cilium toplasm, cytoskeleton, cilium basal body Mitochondrion Cell projection, cilium, photoreceptor outer segment Cytoplasm Note=Localized to the connecting cilium of the cone and rod photoreceptors (PubMed:27548899, PubMed:26974433). Colocalizes with NEK1 and SPATA7 at the basal body (By similarity). Expressed in the retina. Up-regulated during cartilage differentiation (PubMed:26974433). Cilia absent or reduced, virtually no cilia of the normal 5 uM mean length. photoreceptor outer segment molecular_function cytoplasm mitochondrion cytoskeleton plasma membrane cilium cellular response to DNA damage stimulus cytoskeleton organization smoothened signaling pathway regulation of cell shape cell projection organization photoreceptor connecting cilium ciliary basal body DNA damage response, detection of DNA damage cell projection cilium assembly photoreceptor cell cilium uc007fwn.1 uc007fwn.2 uc007fwn.3 
ENSMUST00000105401.9 Trpm2 ENSMUST00000105401.9 transient receptor potential cation channel, subfamily M, member 2 (from RefSeq NM_138301.2) ENSMUST00000105401.1 ENSMUST00000105401.2 ENSMUST00000105401.3 ENSMUST00000105401.4 ENSMUST00000105401.5 ENSMUST00000105401.6 ENSMUST00000105401.7 ENSMUST00000105401.8 Ltrpc2 NM_138301 Q5KTC0 Q91YD4 TRPM2_MOUSE Trpc7 uc007fwl.1 uc007fwl.2 uc007fwl.3 uc007fwl.4 Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11804595, PubMed:19454650, PubMed:21753080, PubMed:22493272). Functions as a ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. Extracellular calcium passes through the channel and increases channel activity (By similarity). Also contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:21753080). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (PubMed:21753080). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (By similarity). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:27533035, PubMed:27562954). Activated by intracellular ADP- ribose, beta-NAD (NAD(+)) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:19454650, PubMed:21753080, PubMed:22493272). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate. Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (By similarity). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) (PubMed:22493272, PubMed:25817999). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis (PubMed:27533035, PubMed:27562954). Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (PubMed:20921208, PubMed:25817999). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection (PubMed:21709234). Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro) (PubMed:22493272). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (PubMed:21753080). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its function in increasing cytoplasmic Ca(2+) and Zn(2+) levels (By similarity). Confers susceptibility to cell death following oxidative stress (PubMed:25562606). Homotetramer. Cell membrane ulti-pass membrane protein Perikaryon Cell projection Cytoplasmic vesicle Lysosome Note=Detected at the cell membrane and in intracellular vesicles in cortical neurons. Detected on neuronal cell bodies and neurites (By similarity). Detected on the cell membrane in polymorphonuclear neutrophils (PubMed:21753080). Detected on cytoplasmic vesicles and lysosomes in immature bone marrow dendritic cells (PubMed:21753080). Detected in the preoptic area of the hypothalamus, a brain area involved in body temperature control (PubMed:27562954). Detected in beta-cells in pancreas islets (at protein level) (PubMed:16601673, PubMed:20921208). Detected in brain cortex, striatum, hippocampus CA1, CA2 and CA3 layers, and in the Purkinje cell layer in cerebellum (PubMed:15708008). Widely expressed, with highest levels in lung, spleen, eye and brain (PubMed:11804595). Detected in dendritic cells and in polymorphonuclear neutrophils (PubMed:21753080). The cytosolic nudix box binds ADP-ribose and is required for channel activation by ADP-ribose. Mutant mice display no obvious phenotype, but display increased blood glucose levels when fed ad libitum (PubMed:20921208). After oral or intraperitoneal glucose administration, they display increased blood glucose and lower plasma insulin levels; basal fasting glucose and insulin levels are not altered (PubMed:20921208). Ca(2+) influx into beta-cells is unchanged under basal conditions or upon stimulation with glucose up to 8.3 mM; Ca(2+) influx is decreased upon stimulation with high glucose levels (16.7 mM) (PubMed:20921208). Likewise, insulin secretion is decreased only upon stimulation with 11.2 or 16.7 mM glucose, but not in response to more moderate glucose levels (PubMed:20921208). Mutant mice have a reduced number of neurons that are activated by warm temperature (34 to 43 degrees Celsius) in their dorsal root ganglia and superior cervical ganglia (PubMed:27533035). Mutant mice show altered behavorial responses to environmental temperature; contrary to wild-type they show no preference for a cooler environment when exposed to 38 degrees Celsius (PubMed:27533035). Besides, they spend less time than wild-type in a cooler environment (23 degrees Celsius) (PubMed:27533035). Mutant mice develop higher fever in response to prostaglandin E2 injection into the preoptic area of the hypothalamus, a brain area involved in body temperature control (PubMed:27562954). Mutant mice display a defective innate immune response and are highly susceptible to infection by L.monocytogenes (PubMed:21709234). They are unable to contain the bacterial infection; contrary to wild-type, they die within a few days after infection (PubMed:21709234). The defective immune response is due to impaired secretion of Il12b and IFNG; mice are rescued by treatment with recombinant IFNG (PubMed:21709234). Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. temperature homeostasis dendritic cell chemotaxis ion channel activity cation channel activity calcium channel activity sodium channel activity manganese ion transmembrane transporter activity calcium ion binding lysosome lysosomal membrane plasma membrane integral component of plasma membrane ion transport cation transport sodium ion transport calcium ion transport manganese ion transport response to oxidative stress response to heat response to purine-containing compound calcium-release channel activity membrane integral component of membrane cytoplasmic vesicle membrane cytoplasmic vesicle positive regulation of insulin secretion response to hydroperoxide ion transmembrane transport calcium-mediated signaling using intracellular calcium source sodium ion transmembrane transport cell projection neuron projection neuronal cell body perikaryon estrous cycle metal ion binding release of sequestered calcium ion into cytosol protein homotetramerization regulation of filopodium assembly transmembrane transport cellular response to hydrogen peroxide calcium ion transmembrane transport cellular response to calcium ion cellular response to purine-containing compound manganese ion transmembrane transport cellular response to temperature stimulus zinc II ion transmembrane transport mono-ADP-D-ribose binding dendritic cell differentiation calcium ion transmembrane import into cytosol calcium ion import across plasma membrane ligand-gated calcium channel activity positive regulation of oxidative stress-induced neuron death regulation of actin cytoskeleton reorganization hydrolase activity ADP-ribose diphosphatase activity uc007fwl.1 uc007fwl.2 uc007fwl.3 uc007fwl.4 
ENSMUST00000105415.3 2610028H24Rik ENSMUST00000105415.3 2610028H24Rik (from geneSymbol) 2610028H24Rik AK161552 E9Q7R5 E9Q7R5_MOUSE ENSMUST00000105415.1 ENSMUST00000105415.2 uc287sjb.1 uc287sjb.2 molecular_function cellular_component biological_process uc287sjb.1 uc287sjb.2 
ENSMUST00000105420.3 Adora2a ENSMUST00000105420.3 adenosine A2a receptor, transcript variant 1 (from RefSeq NM_009630.3) AA2AR_MOUSE ENSMUST00000105420.1 ENSMUST00000105420.2 NM_009630 Q2NLC1 Q60613 uc007fqh.1 uc007fqh.2 uc007fqh.3 uc007fqh.4 Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct (By similarity). May interact with DRD4 (By similarity). Interacts with NECAB2 (By similarity). Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (PubMed:23994616). Cell membrane ; Multi-pass membrane protein Note=Colocalizes with GAS2L2 at neuronal processes. The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface. Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface (By similarity). Belongs to the G-protein coupled receptor 1 family. G-protein coupled adenosine receptor activity synaptic transmission, dopaminergic adenosine receptor signaling pathway response to amphetamine G-protein coupled receptor activity intermediate filament plasma membrane integral component of plasma membrane regulation of transcription, DNA-templated negative regulation of protein kinase activity signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway protein kinase C-activating G-protein coupled receptor signaling pathway synaptic transmission, cholinergic locomotory behavior negative regulation of cell proliferation endomembrane system positive regulation of glutamate secretion positive regulation of acetylcholine secretion, neurotransmission regulation of norepinephrine secretion postsynaptic density membrane integral component of membrane enzyme binding axon dendrite axolemma response to caffeine type 5 metabotropic glutamate receptor binding positive regulation of synaptic transmission, GABAergic asymmetric synapse synaptic transmission, glutamatergic positive regulation of urine volume positive regulation of renal sodium excretion negative regulation of locomotion vasodilation response to drug presynaptic membrane eating behavior identical protein binding neuronal cell body negative regulation of vascular permeability negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to alkaloid negative regulation of neuron apoptotic process postsynaptic membrane positive regulation of circadian sleep/wake cycle, sleep negative regulation of alpha-beta T cell activation protein heterodimerization activity astrocyte activation presynaptic active zone neuron projection morphogenesis positive regulation of protein secretion negative regulation of inflammatory response alpha-actinin binding regulation of mitochondrial membrane potential membrane depolarization regulation of calcium ion transport positive regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential inhibitory postsynaptic potential prepulse inhibition glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane positive regulation of long-term synaptic potentiation regulation of synaptic vesicle exocytosis positive regulation of apoptotic signaling pathway uc007fqh.1 uc007fqh.2 uc007fqh.3 uc007fqh.4 
ENSMUST00000105438.9 Egr2 ENSMUST00000105438.9 early growth response 2, transcript variant 6 (from RefSeq NM_001373987.1) EGR2_MOUSE ENSMUST00000105438.1 ENSMUST00000105438.2 ENSMUST00000105438.3 ENSMUST00000105438.4 ENSMUST00000105438.5 ENSMUST00000105438.6 ENSMUST00000105438.7 ENSMUST00000105438.8 Egr-2 Krox-20 NM_001373987 P08152 Zfp-25 uc007fly.1 uc007fly.2 uc007fly.3 uc007fly.4 Sequence-specific DNA-binding transcription factor (PubMed:1969796, PubMed:1674431, PubMed:11823429, PubMed:31852952). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (PubMed:1969796, PubMed:1674431, PubMed:11823429, PubMed:31852952, PubMed:8093858). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (PubMed:11823429). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (PubMed:1969796, PubMed:8093858, PubMed:17938205). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (PubMed:11823429, PubMed:1674431). Promotes the expression of HOXB3 in the rhombomere r5 and of HOXB3 in r3 and r5 in the hindbrain (PubMed:11823429, PubMed:8093858). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (PubMed:7935840, PubMed:10068633). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (PubMed:11509834). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (PubMed:16054051). E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity. Protein modification; protein sumoylation. Interacts with HCFC1 (By similarity). Interacts with WWP2 (PubMed:19651900). Interacts with UBC9 (By similarity). Interacts with CITED1 (PubMed:17938205). Interacts (via phosphorylated form) with SFN (PubMed:17938205). P08152; Q8C5D8-1: Pias2; NbExp=5; IntAct=EBI-7070449, EBI-8064899; P08152; P63280: Ube2i; NbExp=2; IntAct=EBI-7070449, EBI-80180; Nucleus Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P08152-1; Sequence=Displayed; Name=Short; IsoId=P08152-2; Sequence=VSP_006864; Expressed mainly in the thymus. Before 8 dpc, expressed in the future rhombomere r3 at 0-3 somites, followed by expression in rhombomere r5 in 4-7 somites at 8 dpc, and maintained until 12 somites (PubMed:8093858). Expressed in migrating neural crest cells from r5/r6 (PubMed:8093858). Expressed in boundary cap cells that surround nerve exit points from the central nervous system at 10.5 dpc (PubMed:7935840, PubMed:8093858). Up to 14.5 dpc, expressed in motor and sensory roots of cranial and spinal nerves (PubMed:7935840). After 15.5 dpc, expressed in the entire peripheral nervous system (PubMed:7935840). Expressed in the embryonic nervous system (PubMed:17938205). Expressed in myelinating Schwann cells 2 weeks after birth (PubMed:7935840). Activated during G0/G1 transition in cultured cells. Ubiquitinated by WWP2 leading to proteasomal degradation. Acetylated at Lys-247. May be deacetylated by HDAC6, HDAC10 or SIRT1. Failure to promote expression of the Hoxb3 reporter in rhombomere r5 in the hindbrain (PubMed:11823429). Changed morphology of the sciatic nerves, with a higher density of Schwann cells, and a reduction in major components of compacted myelin, including lipidic components, as well as myelin proteins Mpz and Mbp (PubMed:7935840). Schwann cells in the sciatic nerves exhibit increased expression of Scip, reduced expression of Mpz, elevated mitotic activity and increased apoptosis at postnatal day P12 (PubMed:10068633). Total absence of myelin along the axons of sciatic nerves at postnatal day P15 (PubMed:7935840). Does not seem to affect the myelination in the central nervous system (PubMed:7935840). Signs of atrophy in the jaw openener anterior digastric (AD) and mylohoid (MY) muscles at 15 dpc with smaller diameter fibers, fibers with triangular shape, increased amount of connective tissue surrounding the fibers, suggesting a lack of neural innervation (PubMed:11509834). Reduced volume of the delineated trigeminal motor nucleus and restructuring of the brainstem at 15 dpc (PubMed:11509834). Reduced volume in both AD and MY musculature and reduced milk indigestion after birth (PubMed:11509834). Belongs to the EGR C2H2-type zinc-finger protein family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein export from nucleus learning or memory rhythmic behavior motor neuron axon guidance Schwann cell differentiation transferase activity protein sumoylation rhombomere 3 development facial nerve structural organization rhombomere 3 formation rhombomere 5 formation regulation of ossification ubiquitin protein ligase binding response to insulin brain segmentation skeletal muscle cell differentiation myelination intracellular membrane-bounded organelle transcription regulatory region DNA binding fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding regulation of neuronal synaptic plasticity SUMO ligase activity cellular response to organic substance HMG box domain binding uc007fly.1 uc007fly.2 uc007fly.3 uc007fly.4 
ENSMUST00000105439.2 Lrrtm3 ENSMUST00000105439.2 leucine rich repeat transmembrane neuronal 3 (from RefSeq NM_178678.4) ENSMUST00000105439.1 LRRT3_MOUSE NM_178678 Q14CH3 Q3TQA3 Q8BGJ7 Q8BZ81 uc007fkk.1 uc007fkk.2 uc007fkk.3 May play a role in the development and maintenance of the vertebrate nervous system. Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). Cell membrane ; Single-pass type I membrane protein Postsynaptic cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZ81-1; Sequence=Displayed; Name=2; IsoId=Q8BZ81-2; Sequence=VSP_014191, VSP_014192; Expressed in neuronal tissues. Belongs to the LRRTM family. extracellular space plasma membrane membrane integral component of membrane cell junction extracellular matrix synapse postsynaptic membrane positive regulation of synapse assembly glutamatergic synapse presynapse assembly integral component of postsynaptic density membrane positive regulation of beta-amyloid formation uc007fkk.1 uc007fkk.2 uc007fkk.3 
ENSMUST00000105441.8 Ctnna3 ENSMUST00000105441.8 catenin alpha 3, transcript variant 2 (from RefSeq NM_177612.3) CTNA3_MOUSE Catna3 Ctnna3 ENSMUST00000105441.1 ENSMUST00000105441.2 ENSMUST00000105441.3 ENSMUST00000105441.4 ENSMUST00000105441.5 ENSMUST00000105441.6 ENSMUST00000105441.7 NM_177612 Q3UQ61 Q65CL1 Q8C0N3 uc007fkh.1 uc007fkh.2 uc007fkh.3 uc007fkh.4 May be involved in formation of stretch-resistant cell-cell adhesion complexes. Interacts with CTNNB1 (PubMed:11590244). Interacts with PKP2 (By similarity). Cytoplasm, cytoskeleton Cell junction, desmosome Note=Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2. Colocalizes with PKP2 at intercalated disks in the heart (PubMed:17535849). Expressed in heart (at protein level). Belongs to the vinculin/alpha-catenin family. protein binding cytoplasm cytoskeleton adherens junction fascia adherens cell adhesion beta-catenin binding lamellipodium cadherin binding actin filament binding bundle of His cell-Purkinje myocyte adhesion involved in cell communication regulation of heart rate by cardiac conduction cell-cell adhesion regulation of ventricular cardiac muscle cell action potential uc007fkh.1 uc007fkh.2 uc007fkh.3 uc007fkh.4 
ENSMUST00000105442.3 Sirt1 ENSMUST00000105442.3 sirtuin 1, transcript variant 2 (from RefSeq NM_001159589.2) ENSMUST00000105442.1 ENSMUST00000105442.2 NM_001159589 Q3UNI1 Q3UNI1_MOUSE Sirt1 uc007fkf.1 uc007fkf.2 uc007fkf.3 uc007fkf.4 This gene encodes a member of the sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; NAD+ binding uc007fkf.1 uc007fkf.2 uc007fkf.3 uc007fkf.4 
ENSMUST00000105447.11 Vps26a ENSMUST00000105447.11 VPS26 retromer complex component A, transcript variant 1 (from RefSeq NM_133672.3) ENSMUST00000105447.1 ENSMUST00000105447.10 ENSMUST00000105447.2 ENSMUST00000105447.3 ENSMUST00000105447.4 ENSMUST00000105447.5 ENSMUST00000105447.6 ENSMUST00000105447.7 ENSMUST00000105447.8 ENSMUST00000105447.9 NM_133672 P40336 Q3TGY3 Q3THM5 Q3TW99 Q3UD54 Q8C1E9 VP26A_MOUSE Vps26 uc007fhg.1 uc007fhg.2 uc007fhg.3 uc007fhg.4 Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC complex seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (By similarity). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for the endosomal localization of WASHC2 (indicative for the WASH complex). Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (By similarity). Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2 (By similarity). Acts redundantly with VSP26B in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (PubMed:25136126). Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35 (PubMed:18088321, PubMed:20875039). The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform (Probable). The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex (By similarity). Interacts with VPS29, VPS35, SNX27 (PubMed:18088321, PubMed:20875039, PubMed:25136126). Interacts with SNX1, SNX2, SNX5, SNX6, SNX3, RAB7A, ECPAS, EHD1, WASHC5, SORL1 (By similarity). P40336-1; Q9EQH3: Vps35; NbExp=2; IntAct=EBI-15553779, EBI-775825; Cytoplasm Endosome membrane ; Peripheral membrane protein Early endosome Note=Predominantly found in early not late endosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P40336-1; Sequence=Displayed; Name=2; IsoId=P40336-2; Sequence=VSP_019926; Belongs to the VPS26 family. protein binding cytoplasm lysosome endosome early endosome cytosol intracellular protein transport endosome membrane protein transport membrane retromer complex retromer, cargo-selective complex vesicle retrograde transport, endosome to Golgi tubular endosome retrograde transport, endosome to plasma membrane uc007fhg.1 uc007fhg.2 uc007fhg.3 uc007fhg.4 
ENSMUST00000105454.3 Col13a1 ENSMUST00000105454.3 collagen, type XIII, alpha 1, transcript variant 1 (from RefSeq NM_007731.3) CODA1_MOUSE Col13a1 ENSMUST00000105454.1 ENSMUST00000105454.2 NM_007731 O70575 Q9R1N9 uc007fgn.1 uc007fgn.2 uc007fgn.3 uc007fgn.4 Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625). Homotrimer; disulfide-linked. Nucleation of the type XIII collagen triple helix is likely to occur at the N-terminal region with triple helix formation proceeding from the N- to the C-terminus. Interacts with FN1, perlecan/HSPG2 and NID2 (By similarity). Cell membrane ; Single-pass type II membrane protein Postsynaptic cell membrane Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms may exist. ; Name=1 ; IsoId=Q9R1N9-1; Sequence=Displayed; Name=2 ; IsoId=Q9R1N9-2; Sequence=VSP_052388; Expression levels remain fairly constant during early fetal development. This is followed by a marked increase of expression levels during the final stages of organogenesis, with initiation of the rapid fetal growth phase before birth. At mid- gestation, strongly expressed in the central and peripheral nervous systems. Also strongly expressed in developing heart, with localization to cell-cell contacts and accentuated in intercalated disks perinatally. During late fetal development, expressed in many tissues including cartilage, bone, skeletal muscle, lung, intestine and skin. Not detected in endothelia of most blood vessels or the endocardium of the heart. Transgenic mice overexpressing COL13A1 with a 90 amino acid in-frame deletion of the COL2 sequence show embryonic lethality due either to a lack of placental formation or to cardiovascular defects in offspring from heterozygous mating. In contrast, transgenic mice expressing an N-terminally altered COL13A1 lacking both cytosolic and transmembrane domains while retaining the collagenous ectodomain are viable and fertile, but display progressive muscular myopathy. ossification morphogenesis of a branching structure endochondral ossification extracellular matrix structural constituent collagen trimer extracellular space plasma membrane cell-cell junction cell adhesion cell-matrix adhesion multicellular organism development heparin binding membrane integral component of membrane extracellular matrix structural constituent conferring tensile strength cell junction cell differentiation extracellular matrix organization extracellular matrix synapse postsynaptic membrane cell-cell adhesion uc007fgn.1 uc007fgn.2 uc007fgn.3 uc007fgn.4 
ENSMUST00000105464.9 Cdh23 ENSMUST00000105464.9 cadherin related 23 (otocadherin), transcript variant 3 (from RefSeq NR_045556.1) Cdh23 ENSMUST00000105464.1 ENSMUST00000105464.2 ENSMUST00000105464.3 ENSMUST00000105464.4 ENSMUST00000105464.5 ENSMUST00000105464.6 ENSMUST00000105464.7 ENSMUST00000105464.8 K4DI74 K4DI74_MOUSE NR_045556 uc033fpk.1 uc033fpk.2 uc033fpk.3 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding plasma membrane calcium ion transport cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules sensory perception of sound locomotory behavior membrane integral component of membrane stereocilium photoreceptor cell maintenance sensory perception of light stimulus equilibrioception regulation of cytosolic calcium ion concentration inner ear receptor stereocilium organization uc033fpk.1 uc033fpk.2 uc033fpk.3 
ENSMUST00000105465.8 Psap ENSMUST00000105465.8 prosaposin, transcript variant 5 (from RefSeq NM_001146123.1) ENSMUST00000105465.1 ENSMUST00000105465.2 ENSMUST00000105465.3 ENSMUST00000105465.4 ENSMUST00000105465.5 ENSMUST00000105465.6 ENSMUST00000105465.7 NM_001146123 Psap Q8BFQ1 Q8BFQ1_MOUSE uc033fpi.1 uc033fpi.2 uc033fpi.3 This gene encodes a multifunctional glycoprotein that plays a role in the intracellular metabolism of various sphingolipids or secreted into the plasma, milk or cerebrospinal fluid. The encoded protein undergoes proteolytic processing to generate four different polypeptides known as saposin A, B, C or D, that are required for the hydrolysis of certain sphingolipids by lysosomal hydrolases. Alternately, the encoded protein is secreted into body fluids where it exhibits neurotrophic and myelinotrophic activities. A complete lack of the encoded protein is fatal to mice either at the neonatal stage or within the first month due to severe leukodystrophy and sphingolipid accumulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature saposins. [provided by RefSeq, Sep 2015]. Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin- C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. Lysosome Secreted extracellular space lysosome lipid metabolic process sphingolipid metabolic process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway regulation of lipid metabolic process prostate gland growth epithelial cell differentiation involved in prostate gland development uc033fpi.1 uc033fpi.2 uc033fpi.3 
ENSMUST00000105468.2 Lims1 ENSMUST00000105468.2 LIM and senescent cell antigen-like domains 1, transcript variant 4 (from RefSeq NM_001346676.1) E9QP62 E9QP62_MOUSE ENSMUST00000105468.1 Lims1 NM_001346676 uc007fdb.1 uc007fdb.2 uc007fdb.3 uc007fdb.4 Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Part of the heterotrimeric IPP complex composed of integrin- linked kinase (ILK), LIMS1 or LIMS2, and PARVA. Cell junction, focal adhesion Cell membrane ; Peripheral membrane protein plasma membrane focal adhesion membrane cell junction metal ion binding uc007fdb.1 uc007fdb.2 uc007fdb.3 uc007fdb.4 
ENSMUST00000105473.3 Slc35f1 ENSMUST00000105473.3 solute carrier family 35, member F1 (from RefSeq NM_178675.4) ENSMUST00000105473.1 ENSMUST00000105473.2 NM_178675 Q3TNT3 Q8BGK5 Q8BKD4 Q8BVI2 Q8BX52 S35F1_MOUSE uc007fbk.1 uc007fbk.2 uc007fbk.3 uc007fbk.4 Putative solute transporter. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Belongs to the SLC35F solute transporter family. Sequence=BAC37158.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane transmembrane transporter activity transmembrane transport uc007fbk.1 uc007fbk.2 uc007fbk.3 uc007fbk.4 
ENSMUST00000105490.3 Prdm1 ENSMUST00000105490.3 PR domain containing 1, with ZNF domain, transcript variant 4 (from RefSeq NM_007548.5) A2VDE8 Blimp1 ENSMUST00000105490.1 ENSMUST00000105490.2 NM_007548 PRDM1_MOUSE Q3UET9 Q60636 uc007ezv.1 uc007ezv.2 uc007ezv.3 uc007ezv.4 uc007ezv.5 Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:27102484). Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:27102484). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (By similarity). Drives the maturation of B-lymphocytes into Ig secreting cells (By similarity). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (PubMed:27102484). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (PubMed:32741026). Interacts with PRMT5 (PubMed:16699504). Interacts with FBXO10 (By similarity). Interacts with FBXO11 (By similarity). Interacts with multiple nuclear sumoylation E3 ligases, including CBX4, PIAS1, PIAS2, PIAS3, PIAS4, PML and RNF4, but not RANBP2 (By similarity). Interacts with LDB1, SMARCD3 and SMARCC1 (By similarity). Interacts with EEIG1; following TNFSF11/RANKL stimulation in bone marrow-derived macrophages, the interaction promotes the binding of PRDM1/BLIMP1 to the gene promoter of IRF8 (PubMed:32741026). Q60636; P63165: SUMO1; Xeno; NbExp=3; IntAct=EBI-7000804, EBI-80140; Nucleus Cytoplasm Event=Alternative promoter usage, Alternative splicing; Named isoforms=5; Name=1; IsoId=Q60636-1; Sequence=Displayed; Name=2; Synonyms=1A; IsoId=Q60636-2; Sequence=VSP_039189; Name=3; Synonyms=1B; IsoId=Q60636-3; Sequence=VSP_041570; Name=4; Synonyms=1C; IsoId=Q60636-4; Sequence=VSP_041571; Name=5; Synonyms=delta exon 7; IsoId=Q60636-5; Sequence=VSP_041572; Expressed in bone marrow macrophages (at protein level) (PubMed:32741026). Expressed in innate lymphocytes, including tissue-resident conventional natural killer (cNK) cells in liver (PubMed:27102484). Expressed also weakly in tissue-resident natural killer (trNK) and natural killer T (NKT) cells in liver (PubMed:27102484). [Isoform 1]: Expressed in bone marrow, spleen and lymph node but not in brain, heart, kidney, liver, ovary or muscle. Weak expression detected in the lung. [Isoform 3]: Expressed only in the yolk sac. [Isoform 4]: Expressed in embryo, yolk sac, placenta, splenocytes, and activated T-cells. By lymphokines, specifically IL-2 and IL-5. Up-regulated during dendritic cell maturation. (Microbial infection) Up-regulated in response to Herpes simplex virus (HSV) infection in skin and spleen memory CD8(+) T cells. (Microbial infection) Up-regulated in response to Lymphocytic choriomeningitis virus (LCMV) in memory CD8(+) T cells. Sumoylation at Lys-847 by PIAS1 increases transcriptional repressor activity, and is critical for plasma cell differentiation (By similarity). Can be sumoylated with SUMO1 and SUMO2 by PML. Degradation of the wild-type protein mostly depends upon sumoylation, rather than ubiquitination (By similarity). Desumoylated by SENP1 and SENP6 (By similarity). Ubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome. Early embryonic lethality (PubMed:19737919). Compound heterozygotes display germ cell defects and a rudimentary or missing fifth digit of the forelimb (PubMed:19737919). Conditional knockout in lymphocyte T cells show a weak reduction in tissue-resident memory T (Trm) cell population maintenance in the skin, gut, liver and kidney but not of splenic T cells (PubMed:27102484). Double knockouts for PRDM1/BLIMP1 and ZNF683 result in a strong inhibition of Trm cell population maintenance but not of circulating memory cells (PubMed:27102484). Display an enhancement of natural killer T (NKT) cells migration preferentially to the white pulp of the spleen in response to chemotactic stimuli (PubMed:27102484). [Isoform 1]: Produced by alternative splicing. [Isoform 2]: Produced by alternative splicing of isoform 1. [Isoform 3]: Produced by alternative promoter usage of isoform 2. [Isoform 4]: Produced by alternative promoter usage of isoform 2. [Isoform 5]: Produced by alternative splicing of isoform 1. Does not bind DNA. Belongs to the class V-like SAM-binding methyltransferase superfamily. Sequence=AAI29802.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development morphogenesis of a branching structure embryonic placenta development maternal placenta development adaptive immune response immune system process heart valve development cardiac septum development ventricular septum development nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm multicellular organism development germ cell development methyltransferase activity post-embryonic development positive regulation of gene expression negative regulation of gene expression transferase activity negative regulation of B cell proliferation chromatin DNA binding negative regulation of lipopolysaccharide-mediated signaling pathway methylation regulation of natural killer cell differentiation regulation of extrathymic T cell differentiation aorta development regulation of cell proliferation eye photoreceptor cell development histone deacetylase binding sequence-specific DNA binding innate immune response cell fate commitment positive regulation of B cell differentiation metal ion binding artery morphogenesis regulation of NK T cell differentiation intestinal epithelial cell development trophoblast giant cell differentiation coronary vasculature development sebum secreting cell proliferation promoter-specific chromatin binding uc007ezv.1 uc007ezv.2 uc007ezv.3 uc007ezv.4 uc007ezv.5 
ENSMUST00000105502.8 Foxo3 ENSMUST00000105502.8 forkhead box O3, transcript variant 2 (from RefSeq NM_019740.3) D3Z6Y6 ENSMUST00000105502.1 ENSMUST00000105502.2 ENSMUST00000105502.3 ENSMUST00000105502.4 ENSMUST00000105502.5 ENSMUST00000105502.6 ENSMUST00000105502.7 FOXO3_MOUSE Fkhr2 Foxo3 Foxo3a NM_019740 Q05CZ4 Q9WVH4 uc007eym.1 uc007eym.2 uc007eym.3 Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:18054316, PubMed:18054315, PubMed:23805378). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (PubMed:18054316, PubMed:18054315, PubMed:25402684). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (By similarity). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR- 34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (By similarity). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (PubMed:32103177). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (By similarity). Upon metabolic stress, forms a complex composed of FOXO3, SIRT3 and mitochondrial RNA polymerase POLRMT; the complex is recruited to mtDNA in a SIRT3-dependent manner (PubMed:23283301). Also forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT (By similarity). Interacts with SIRT2; the interaction occurs independently of SIRT2 deacetylase activity (PubMed:17521387). Interacts with YWHAB/14-3-3- beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1. Interacts with DDIT3/CHOP. Interacts (deacetylated form) with SKP2. Interacts with CHUK and IKBKB (By similarity). Interacts with CAMK2A, CAMK2B and calcineurin A (PubMed:23805378). Interacts with NUPR1; this interaction represses FOXO3 transactivation (By similarity). Q9WVH4; P0DJI6: Fcor; NbExp=2; IntAct=EBI-6127038, EBI-6126630; Q9WVH4; Q8WTS6: SETD7; Xeno; NbExp=5; IntAct=EBI-6127038, EBI-1268586; Cytoplasm, cytosol cleus tochondrion matrix Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Retention in the cytoplasm contributes to its inactivation (By similarity). Translocates to the nucleus upon oxidative stress and in the absence of survival factors (By similarity). Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (PubMed:18054315). Translocates in a AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, PubMed:29445193). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (PubMed:32103177). Expressed in white and brown adipose tissues (at protein level) (PubMed:22510882). Expressed in liver, kidney, lung and colon (at protein level) (PubMed:29445193). Expressed in skeletal muscles (at protein level) (PubMed:23283301). Deacetylation by SIRT1 or SIRT2 stimulates interaction of FOXO3 with SKP2 and facilitates SCF(SKP2)-mediated FOXO3 ubiquitination and proteasomal degradation (By similarity). Deacetylation by SIRT2 stimulates FOXO3-mediated transcriptional activity in response to oxidative stress (PubMed:17521387). Deacetylated by SIRT3 (By similarity). Deacetylation by SIRT3 stimulates FOXO3-mediated mtDNA transcriptional activity in response to metabolic stress (By similarity). In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-252 by AKT1/PKB (Probable). This phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm (Probable). Survival factor withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein induces transcription of target genes and triggers apoptosis (By similarity). Although AKT1/PKB doesn't appear to phosphorylate Ser- 314 directly, it may activate other kinases that trigger phosphorylation at this residue (By similarity). Phosphorylated by STK4/MST1 on Ser-208 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation (By similarity). Phosphorylated by PIM1 (By similarity). Phosphorylation by AMPK leads to the activation of transcriptional activity without affecting subcellular localization (By similarity). Phosphorylated by AMPK on Ser-30 in response to metabolic stress which mediates FOXO3 mitochondrial translocation (By similarity). Phosphorylation by MAPKAPK5 promotes nuclear localization and DNA-binding, leading to induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (By similarity). Phosphorylated by CHUK/IKKA and IKBKB/IKKB (By similarity). TNF-induced inactivation of FOXO3 requires its phosphorylation at Ser-643 by IKBKB/IKKB which promotes FOXO3 retention in the cytoplasm, polyubiquitination and ubiquitin-mediated proteasomal degradation (By similarity). May be dephosphorylated by calcineurin A on Ser-298 which abolishes FOXO3 transcriptional activity (PubMed:23805378). Phosphorylation at Ser-252 promotes its degradation by the proteasome (By similarity). Dephosphorylation at Ser-252 by protein phosphatase 2A (PPP2CA) promotes its stabilization; interaction with PPP2CA is enhanced by AMBRA1 (By similarity). Heavily methylated by SET9 which decreases stability, while moderately increasing transcriptional activity. The main methylation site is Lys-270. Methylation doesn't affect subcellular location. Polyubiquitinated. Ubiquitinated by a SCF complex containing SKP2, leading to proteasomal degradation. The N-terminus is cleaved following import into the mitochondrion. Sequence=AAH19532.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ovulation from ovarian follicle initiation of primordial ovarian follicle growth antral ovarian follicle growth oocyte maturation DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane mitochondrial matrix cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from mitochondrial promoter regulation of translation apoptotic process aging beta-catenin binding transcription factor binding insulin receptor signaling pathway positive regulation of autophagy positive regulation of muscle atrophy membrane protein kinase binding DNA damage response, signal transduction by p53 class mediator negative regulation of cell migration chromatin DNA binding response to nutrient levels macromolecular complex tumor necrosis factor-mediated signaling pathway mitochondrial RNA polymerase binding promoter specificity activity cellular response to oxidative stress response to drug glucose homeostasis response to starvation positive regulation of apoptotic process positive regulation of neuron apoptotic process sequence-specific DNA binding positive regulation of erythrocyte differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter brain morphogenesis cellular response to glucose stimulus cellular response to corticosterone stimulus cellular response to hypoxia response to dexamethasone negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance extrinsic apoptotic signaling pathway in absence of ligand positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of reactive oxygen species biosynthetic process cellular response to beta-amyloid cellular response to nerve growth factor stimulus response to water-immersion restraint stress regulation of neural precursor cell proliferation positive regulation of endothelial cell apoptotic process regulation of reactive oxygen species metabolic process uc007eym.1 uc007eym.2 uc007eym.3 
ENSMUST00000105507.5 Ppil6 ENSMUST00000105507.5 peptidylprolyl isomerase (cyclophilin)-like 6, transcript variant 10 (from RefSeq NR_176441.1) B2RWF7 ENSMUST00000105507.1 ENSMUST00000105507.2 ENSMUST00000105507.3 ENSMUST00000105507.4 NR_176441 PPIL6_MOUSE Ppil6 Q9D6D8 uc007exu.1 uc007exu.2 uc007exu.3 uc007exu.4 Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. Belongs to the cyclophilin-type PPIase family. Despite the fact that it belongs to the cyclophilin-type PPIase family, it has probably no peptidyl-prolyl cis-trans isomerase activity. Sequence=BAB29003.1; Type=Frameshift; Evidence=; protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity cyclosporin A binding protein refolding unfolded protein binding uc007exu.1 uc007exu.2 uc007exu.3 uc007exu.4 
ENSMUST00000105511.2 Col10a1 ENSMUST00000105511.2 collagen, type X, alpha 1 (from RefSeq NM_009925.4) COAA1_MOUSE ENSMUST00000105511.1 NM_009925 Q05306 uc011xcr.1 uc011xcr.2 Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. Homotrimer. Secreted, extracellular space, extracellular matrix Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. endochondral ossification extracellular matrix structural constituent extracellular region collagen trimer extracellular space cell cortex extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix receptor complex metal ion binding cartilage development uc011xcr.1 uc011xcr.2 
ENSMUST00000105522.9 H60b ENSMUST00000105522.9 Ligand for the KLRK1 immunosurveillance receptor. Binding to KLRK1 stimulates cell lysis in vitro. (from UniProt B1B212) AB284505 B1B212 ENSMUST00000105522.1 ENSMUST00000105522.2 ENSMUST00000105522.3 ENSMUST00000105522.4 ENSMUST00000105522.5 ENSMUST00000105522.6 ENSMUST00000105522.7 ENSMUST00000105522.8 H60B_MOUSE H60b uc011xbl.1 uc011xbl.2 uc011xbl.3 Ligand for the KLRK1 immunosurveillance receptor. Binding to KLRK1 stimulates cell lysis in vitro. Cell membrane ; Single-pass type I membrane protein In strain C57BL/6J, strongly expressed in cardiac muscle and skeletal muscle, with lower expression levels in spleen, liver, kidney and thymus. In strain BALB/cJ, weakly expressed in cardiac muscle, spleen, kidney and thymus. Up-regulated in response to infection by murine cytomegalovirus. Belongs to the NKG2D ligand family. immune system process extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane natural killer cell mediated cytotoxicity natural killer cell lectin-like receptor binding uc011xbl.1 uc011xbl.2 uc011xbl.3 
ENSMUST00000105525.12 Ahi1 ENSMUST00000105525.12 Abelson helper integration site 1, transcript variant 1 (from RefSeq NM_026203.3) Ahi1 E9QP54 E9QP54_MOUSE ENSMUST00000105525.1 ENSMUST00000105525.10 ENSMUST00000105525.11 ENSMUST00000105525.2 ENSMUST00000105525.3 ENSMUST00000105525.4 ENSMUST00000105525.5 ENSMUST00000105525.6 ENSMUST00000105525.7 ENSMUST00000105525.8 ENSMUST00000105525.9 NM_026203 uc007eod.1 uc007eod.2 uc007eod.3 centrosome cell-cell junction adherens junction cilium ciliary basal body identical protein binding uc007eod.1 uc007eod.2 uc007eod.3 
ENSMUST00000105543.9 Phactr2 ENSMUST00000105543.9 phosphatase and actin regulator 2, transcript variant E (from RefSeq NM_001359294.1) A3KGD2 ENSMUST00000105543.1 ENSMUST00000105543.2 ENSMUST00000105543.3 ENSMUST00000105543.4 ENSMUST00000105543.5 ENSMUST00000105543.6 ENSMUST00000105543.7 ENSMUST00000105543.8 NM_001359294 Phactr2 Q3UQ19 Q3UQ19_MOUSE uc007ekq.1 uc007ekq.2 uc007ekq.3 uc007ekq.4 Binds PPP1CA and actin. Belongs to the phosphatase and actin regulator family. molecular_function actin binding protein phosphatase inhibitor activity cellular_component biological_process negative regulation of phosphoprotein phosphatase activity uc007ekq.1 uc007ekq.2 uc007ekq.3 uc007ekq.4 
ENSMUST00000105569.5 Klhl17 ENSMUST00000105569.5 kelch-like 17 (from RefSeq NM_198305.2) ENSMUST00000105569.1 ENSMUST00000105569.2 ENSMUST00000105569.3 ENSMUST00000105569.4 KLH17_MOUSE NM_198305 Q6TDP3 uc008wgs.1 uc008wgs.2 uc008wgs.3 Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). Protein modification; protein ubiquitination. Interacts with F-actin; the interaction disrupts the F-actin structures and leads to marked changes of neuronal morphology. Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts directly with PDZK1 (via PDZ1 domain); the interaction is important for integrity of actin cytoskeleton structures in neurons. Interacts with DLG4 and SYNGAP1. Interacts (via kelch repeats) with GRIK2 (via C-terminus); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway. Interacts with GRIK1. Interacts with (via BTB domain) CUL3; the interaction regulates surface GRIK2 expression (By similarity). Postsynaptic density Synapse actin binding plasma membrane brain development postsynaptic density actin cytoskeleton membrane protein ubiquitination actin cytoskeleton organization cell junction POZ domain binding dendrite cytoplasm neuronal cell body synapse postsynaptic membrane actin filament binding binding, bridging uc008wgs.1 uc008wgs.2 uc008wgs.3 
ENSMUST00000105572.3 Perm1 ENSMUST00000105572.3 PPARGC1 and ESRR induced regulator, muscle 1 (from RefSeq NM_172417.3) E9QP35 ENSMUST00000105572.1 ENSMUST00000105572.2 NM_172417 PERM1_MOUSE Q149B8 Q8BS19 Q8CB71 uc008wgm.1 uc008wgm.2 uc008wgm.3 Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. Cytoplasm Nucleus Note=Shows a nuclear localization in the presence of PPARGC1A. Highly expressed in skeletal muscles and heart with lower levels in brown adipose tissue (at protein level). Muscle- specific expression is increased by endurance exercise. By PPARGC1A, PPARGC1B, ESRRA, ESRRB and ESRRG. Sequence=BAC29522.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC30714.1; Type=Frameshift; Evidence=; molecular_function nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated response to muscle activity uc008wgm.1 uc008wgm.2 uc008wgm.3 
ENSMUST00000105584.10 Acap3 ENSMUST00000105584.10 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 (from RefSeq NM_207223.1) Acap3 Centb5 ENSMUST00000105584.1 ENSMUST00000105584.2 ENSMUST00000105584.3 ENSMUST00000105584.4 ENSMUST00000105584.5 ENSMUST00000105584.6 ENSMUST00000105584.7 ENSMUST00000105584.8 ENSMUST00000105584.9 NM_207223 Q6NXL5 Q6NXL5_MOUSE uc033ihg.1 uc033ihg.2 uc033ihg.3 GTPase-activating protein for the ADP ribosylation factor family. GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid. Endosome membrane ; Peripheral membrane protein PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes. The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. neuron migration GTPase activator activity regulation of neuron projection development growth cone positive regulation of GTPase activity metal ion binding uc033ihg.1 uc033ihg.2 uc033ihg.3 
ENSMUST00000105590.8 Esr1 ENSMUST00000105590.8 estrogen receptor 1 (alpha), transcript variant 3 (from RefSeq NM_001302532.1) ENSMUST00000105590.1 ENSMUST00000105590.2 ENSMUST00000105590.3 ENSMUST00000105590.4 ENSMUST00000105590.5 ENSMUST00000105590.6 ENSMUST00000105590.7 ESR1_MOUSE Esr Estr Estra NM_001302532 Nr3a1 P19785 Q9JJT5 Q9QY51 Q9QY52 uc007egw.1 uc007egw.2 uc007egw.3 uc007egw.4 This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa- B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Interacts with BCAS3. Binds DNA as a homodimer (By similarity). Can form a heterodimer with ESR2 (By similarity). Interacts with coactivator NCOA5. Interacts with PELP1, the interaction is enhanced by 17-beta-estradiol; the interaction increases ESR1 transcriptional activity (By similarity). Interacts with NCOA7; the interaction is ligand-inducible. Interacts with AKAP13, CUEDC2, HEXIM1, KDM5A, MAP1S, SMARD1, and UBE1C. Interacts with MUC1; the interaction is stimulated by 7 beta-estradiol (E2) and enhances ESR1-mediated transcription. Interacts with DNTTIP2, and UIMC1. Interacts with KMT2D/MLL2. Interacts with ATAD2; the interaction is enhanced by estradiol. Interacts with KIF18A and LDB1. Interacts with RLIM (via its C-terminus). Interacts with MACROD1. Interacts with SH2D4A and PLCG. Interacts with SH2D4A; the interaction blocks binding to PLCG and inhibits estrogen-induced cell proliferation. Interacts with DYNLL1. Interacts with CCDC62; the interaction requires estradiol and appears to enhance the transcription of target genes. Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with DNAAF4. Interacts with PRMT2. Interacts with RBFOX2. Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with CITED1; the interaction is estrogen-dependent (By similarity). Interacts with FAM120B, FOXL2, PHB2 and SLC30A9. Interacts with coactivators NCOA3 and NCOA6. Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa. Binds to CSNK1D. Interacts with NCOA2; NCOA2 can interact with ESR1 AF-1 and AF-2 domains simultaneously and mediate their transcriptional synergy. Interacts with DDX5. Interacts with NCOA1; the interaction seems to require a self-association of N- terminal and C-terminal regions. Interacts with ZNF366, DDX17, NFKB1, RELA, SP1 and SP3. Interacts with NRIP1 (By similarity). Interacts with GPER1; the interaction occurs in an estrogen-dependent manner. Interacts with CLOCK and the interaction is stimulated by estrogen (By similarity). Interacts with BCAS3. Interacts with TRIP4 (ufmylated); estrogen dependent (By similarity). Interacts with LMTK3; the interaction phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts with ZFHX3 (By similarity). Interacts with SFR1 in a ligand-dependent and -independent manner (By similarity). Interacts with DCAF13, LATS1 and DCAF1; regulates ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation (By similarity). Interacts (via DNA-binding domain) with POU4F2 isoform 2 (C-terminus); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol- independent manner (PubMed:9448000). Interacts with ESRRB isoform 1 (By similarity). Interacts with UBE3A and WBP2 (By similarity). Interacts with GTF2B (By similarity). Interacts with RBM39 (PubMed:11704680). In the absence of hormonal ligand, interacts with TACC1 (By similarity). Interacts with PI3KR1 or PI3KR2 and PTK2/FAK1 (By similarity). Interacts with SRC (By similarity). P19785; Q00175: Pgr; NbExp=5; IntAct=EBI-346765, EBI-346821; P19785; Q15788: NCOA1; Xeno; NbExp=3; IntAct=EBI-346765, EBI-455189; P19785; O94763: URI1; Xeno; NbExp=2; IntAct=EBI-346765, EBI-357067; Nucleus Cytoplasm Golgi apparatus Cell membrane Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand- independent transactivation function. The C-terminus contains a ligand- dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity). Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Dephosphorylation at Ser-122 by PPP5C inhibits its transactivation activity (By similarity). Phosphorylated by LMTK3 (in vitro) (By similarity). Ubiquitinated. Deubiquitinated by OTUB1 (By similarity). Palmitoylated at Cys-451 by ZDHHC7 and ZDHHC21. This modification is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor. Ubiquitinated; regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation. Deubiquitinated by OTUB1. Dimethylated by PRMT1 at Arg-264. The methylation may favor cytoplasmic localization. Demethylated by JMJD6 at Arg-264. Belongs to the nuclear hormone receptor family. NR3 subfamily. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding TFIIB-class transcription factor binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding antral ovarian follicle growth epithelial cell development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding steroid binding protein binding nucleus cytoplasm mitochondrion Golgi apparatus plasma membrane regulation of transcription, DNA-templated transcription from RNA polymerase II promoter phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration beta-catenin binding transcription factor binding androgen metabolic process zinc ion binding lipid binding male gonad development negative regulation of gene expression positive regulation of phospholipase C activity membrane TBP-class protein binding enzyme binding protein kinase binding estrogen receptor activity T-tubule estrogen receptor binding intracellular steroid hormone receptor signaling pathway intracellular estrogen receptor signaling pathway type 1 metabotropic glutamate receptor binding response to estradiol macromolecular complex estrogen response element binding regulation of toll-like receptor signaling pathway transcriptionally active chromatin phosphatidylinositol 3-kinase regulatory subunit binding hormone binding identical protein binding regulation of apoptotic process neuron projection negative regulation of I-kappaB kinase/NF-kappaB signaling terminal bouton perikaryon steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity regulation of neuron apoptotic process sequence-specific DNA binding response to estrogen macromolecular complex binding positive regulation of nitric oxide biosynthetic process positive regulation of epidermal growth factor receptor signaling pathway negative regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of RNA polymerase II transcriptional preinitiation complex assembly positive regulation of transcription from RNA polymerase II promoter negative regulation of glucose import metal ion binding positive regulation of fibroblast proliferation perinuclear region of cytoplasm negative regulation of smooth muscle cell proliferation stem cell differentiation positive regulation of epithelial cell proliferation regulation of inflammatory response positive regulation of nitric-oxide synthase activity positive regulation of sequence-specific DNA binding transcription factor activity ATPase binding Sertoli cell proliferation uterus development vagina development prostate epithelial cord elongation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis regulation of branching involved in prostate gland morphogenesis mammary gland branching involved in pregnancy mammary gland alveolus development epithelial cell proliferation involved in mammary gland duct elongation positive regulation of ERK1 and ERK2 cascade protein localization to chromatin cellular response to estrogen stimulus cellular response to estradiol stimulus negative regulation of triglyceride metabolic process transcriptional preinitiation complex negative regulation of neuron death negative regulation of production of miRNAs involved in gene silencing by miRNA promoter-specific chromatin binding uc007egw.1 uc007egw.2 uc007egw.3 uc007egw.4 
ENSMUST00000105607.8 Oprm1 ENSMUST00000105607.8 opioid receptor, mu 1, transcript variant MOR-1 (from RefSeq NM_001302793.1) A1XGX3 A1XGX4 A1YAC3 A1YAC4 A5H7G2 ENSMUST00000105607.1 ENSMUST00000105607.2 ENSMUST00000105607.3 ENSMUST00000105607.4 ENSMUST00000105607.5 ENSMUST00000105607.6 ENSMUST00000105607.7 Mor NM_001302793 OPRM_MOUSE Oprm P42866 Q4U2P4 Q4U2Q6 Q548C6 Q60768 Q6YC50 Q8CAN5 Q8CGW2 Q8CH73 Q8CH74 Q8CH75 Q8VBU3 Q8VBU6 Q8VBX8 Q8VI69 Q8VI70 Q8VI71 Q8VIN3 Q8VIN4 Q8VIN5 Q8VIN6 Q8VIP0 Q8VIP1 Q9JIY1 Q9R0D1 Q9R1L9 Q9R1M0 uc007efw.1 uc007efw.2 uc007efw.3 uc007efw.4 uc007efw.5 This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]. Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:21422164, PubMed:22437502, PubMed:10842167, PubMed:16682964, PubMed:26245379, PubMed:7797593, PubMed:9037090). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:16682964, PubMed:7797593, PubMed:9037090). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (PubMed:6933569, PubMed:35201898). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:10842167, PubMed:21422164, PubMed:22437502). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:9767386, PubMed:26245379). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (PubMed:15827571, PubMed:17725581). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (PubMed:12642578). The activation of the ERK pathway occurs either in a G-protein- dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta- arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity). [Isoform 9]: Isoform 9 is involved in morphine-induced scratching and seems to cross-activate GRPR in response to morphine. Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms) (PubMed:10842167, PubMed:12270145, PubMed:18836069, PubMed:21422164). Interacts with heterotrimeric G proteins; interaction with a heterotrimeric complex containing GNAI1, GNB1 and GNG2 stabilizes the active conformation of the receptor and increases its affinity for endomorphin-2, the synthetic opioid peptide DAMGO and for morphinan agonists (PubMed:26245379). Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS and GPM6A (By similarity). Interacts with RTP4 (PubMed:18836069). Interacts with SYP and GNAS (By similarity). Interacts with RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1 (PubMed:15827571, PubMed:17725581, PubMed:18439408, PubMed:21153910). Isoform 9 interacts with GRPR (PubMed:22000021). P42866; P04899: GNAI2; Xeno; NbExp=2; IntAct=EBI-5282656, EBI-353997; P42866; P63092-2: GNAS; Xeno; NbExp=2; IntAct=EBI-5282656, EBI-7607528; P42866-9; P21729: Grpr; NbExp=4; IntAct=EBI-6049667, EBI-6049651; Cell membrane ulti-pass membrane protein ll projection, axon Perikaryon Cell projection, dendrite Endosome Note=Is rapidly internalized after agonist binding. Event=Alternative splicing; Named isoforms=19; Comment=Additional isoforms seem to exist. Functional relevance for short isoforms with one transmembrane domain only is unsure and these isoforms are not included.; Name=1; Synonyms=MOR-1, MOR-H, MOR-1J, MOR-1T; IsoId=P42866-1; Sequence=Displayed; Name=2; Synonyms=MOR-1A; IsoId=P42866-2; Sequence=VSP_042339; Name=3; Synonyms=MOR-1B1; IsoId=P42866-3; Sequence=VSP_042340; Name=4; Synonyms=MOR-1B2; IsoId=P42866-4; Sequence=VSP_042341; Name=5; Synonyms=MOR-1B3, MOR-1Q; IsoId=P42866-5; Sequence=VSP_042342; Name=6; Synonyms=MOR-1B4, MOR-1R; IsoId=P42866-6; Sequence=VSP_042343; Name=7; Synonyms=MOR-1B5, MOR-1P; IsoId=P42866-7; Sequence=VSP_042344; Name=8; Synonyms=MOR-1C; IsoId=P42866-8; Sequence=VSP_042345; Name=9; Synonyms=MOR-1D; IsoId=P42866-9; Sequence=VSP_042346; Name=10; Synonyms=MOR-1E, MOR-1Eiii, MOR-1Eiv; IsoId=P42866-10; Sequence=VSP_042333; Name=11; Synonyms=MOR-1F; IsoId=P42866-11; Sequence=VSP_042334; Name=12; Synonyms=MOR-1O; IsoId=P42866-12; Sequence=VSP_042335; Name=13; Synonyms=MOR-1P, MOR-1R; IsoId=P42866-13; Sequence=VSP_042336; Name=14; Synonyms=MOR-1G; IsoId=P42866-14; Sequence=VSP_042332; Name=15; Synonyms=MOR-1M; IsoId=P42866-15; Sequence=VSP_042332, VSP_042345; Name=16; Synonyms=MOR-1N; IsoId=P42866-16; Sequence=VSP_042332, VSP_042346; Name=17; Synonyms=MOR-1U; IsoId=P42866-17; Sequence=VSP_042337; Name=18; Synonyms=MOR-1V; IsoId=P42866-18; Sequence=VSP_042338; Name=19; Synonyms=MOR-1W; IsoId=P42866-19; Sequence=VSP_042347; Phosphorylated. Differentially phosphorylated in basal and agonist-induced conditions. Agonist-mediated phosphorylation modulates receptor internalization. Phosphorylated by GRK2 in a agonist-dependent manner. Phosphorylation at Tyr-166 requires receptor activation, is dependent on non-receptor protein tyrosine kinase Src and results in a decrease in agonist efficacy by reducing G-protein coupling efficiency. Phosphorylated on tyrosine residues; the phosphorylation is involved in agonist-induced G-protein-independent receptor down-regulation. Phosphorylation at Ser-375 is involved in G-protein-dependent but not beta-arrestin-dependent activation of the ERK pathway. Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4. During adult neurogenesis in hippocampus, increased numbers of granule cells maturing into neurons, larger granule cell layers and increased numbers of granule cells. Belongs to the G-protein coupled receptor 1 family. G-protein alpha-subunit binding acute inflammatory response to antigenic stimulus G-protein coupled receptor activity beta-endorphin receptor activity opioid receptor activity voltage-gated calcium channel activity protein binding cytoplasm endosome plasma membrane integral component of plasma membrane focal adhesion signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway locomotory behavior protein C-terminus binding response to radiation membrane integral component of membrane sensory perception of pain protein domain specific binding axon dendrite filamin binding adenylate cyclase-inhibiting opioid receptor signaling pathway G-protein beta-subunit binding response to food positive regulation of appetite response to lipopolysaccharide dendrite membrane dendrite cytoplasm opioid receptor signaling pathway morphine receptor activity wound healing response to cocaine peptide binding sarcolemma eating behavior neuropeptide binding cell projection perikaryon response to morphine positive regulation of cAMP-mediated signaling negative regulation of cAMP-mediated signaling estrous cycle negative regulation of nitric oxide biosynthetic process membrane raft positive regulation of nitric oxide biosynthetic process response to ethanol behavioral response to ethanol positive regulation of neurogenesis negative regulation of cytosolic calcium ion concentration regulation of sensory perception of pain excitatory postsynaptic potential negative regulation of Wnt protein secretion positive regulation of ERK1 and ERK2 cascade calcium ion transmembrane transport response to growth factor cellular response to morphine regulation of cellular response to stress spine apparatus integral component of postsynaptic membrane integral component of presynaptic membrane regulation of N-methyl-D-aspartate selective glutamate receptor activity uc007efw.1 uc007efw.2 uc007efw.3 uc007efw.4 uc007efw.5 
ENSMUST00000105608.9 Slc35e2 ENSMUST00000105608.9 solute carrier family 35, member E2 (from RefSeq NM_177186.4) ENSMUST00000105608.1 ENSMUST00000105608.2 ENSMUST00000105608.3 ENSMUST00000105608.4 ENSMUST00000105608.5 ENSMUST00000105608.6 ENSMUST00000105608.7 ENSMUST00000105608.8 NM_177186 Q8C811 S35E2_MOUSE Slc35e2 Slc35e2a uc008wdw.1 uc008wdw.2 uc008wdw.3 Putative transporter. Membrane ; Multi-pass membrane protein Belongs to the TPT transporter family. SLC35E subfamily. blastocyst hatching Golgi apparatus antiporter activity membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008wdw.1 uc008wdw.2 uc008wdw.3 
ENSMUST00000105610.3 Gm17106 ENSMUST00000105610.3 Gm17106 (from geneSymbol) ENSMUST00000105610.1 ENSMUST00000105610.2 uc289efl.1 uc289efl.2 uc289efl.1 uc289efl.2 
ENSMUST00000105638.9 Prdm16 ENSMUST00000105638.9 Prdm16 (from geneSymbol) A2A933 A2A933_MOUSE AK083829 ENSMUST00000105638.1 ENSMUST00000105638.2 ENSMUST00000105638.3 ENSMUST00000105638.4 ENSMUST00000105638.5 ENSMUST00000105638.6 ENSMUST00000105638.7 ENSMUST00000105638.8 Prdm16 uc008wbt.1 uc008wbt.2 uc008wbt.3 nucleic acid binding uc008wbt.1 uc008wbt.2 uc008wbt.3 
ENSMUST00000105646.3 Ajap1 ENSMUST00000105646.3 adherens junction associated protein 1 (from RefSeq NM_001099299.1) A2ALI5 AJAP1_MOUSE B2RVK0 ENSMUST00000105646.1 ENSMUST00000105646.2 Gm573 NM_001099299 uc008was.1 uc008was.2 uc008was.3 Plays a role in cell adhesion and cell migration. Forms a complex with CDH1 and CTNNB1; interacts directly with CTNNB1 (By similarity). Interacts with AP1M2 and isoform 2 of BSG/CD147 (By similarity). Basolateral cell membrane ; Single-pass type I membrane protein Apical cell membrane ; Single-pass type I membrane protein Cell junction, adherens junction Note=Mainly basolateral. Localization is mediated by AP1M2. negative regulation of cell-matrix adhesion plasma membrane adherens junction cell-cell adherens junction cell adhesion beta-catenin binding cytoplasmic side of plasma membrane cell surface membrane integral component of membrane basolateral plasma membrane apical plasma membrane cell junction regulation of polarized epithelial cell differentiation spanning component of plasma membrane cell-cell contact zone macromolecular complex binding negative regulation of wound healing uc008was.1 uc008was.2 uc008was.3 
ENSMUST00000105650.8 Gpr153 ENSMUST00000105650.8 G protein-coupled receptor 153, transcript variant 2 (from RefSeq NM_001374784.1) A2A8K5 A2A8K5_MOUSE ENSMUST00000105650.1 ENSMUST00000105650.2 ENSMUST00000105650.3 ENSMUST00000105650.4 ENSMUST00000105650.5 ENSMUST00000105650.6 ENSMUST00000105650.7 Gpr153 NM_001374784 uc290seb.1 uc290seb.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity G-protein coupled receptor signaling pathway membrane integral component of membrane uc290seb.1 uc290seb.2 
ENSMUST00000105661.10 Plekhg5 ENSMUST00000105661.10 pleckstrin homology domain containing, family G (with RhoGef domain) member 5, transcript variant 1 (from RefSeq NM_001285999.3) A2A8B6 A2A8B7 ENSMUST00000105661.1 ENSMUST00000105661.2 ENSMUST00000105661.3 ENSMUST00000105661.4 ENSMUST00000105661.5 ENSMUST00000105661.6 ENSMUST00000105661.7 ENSMUST00000105661.8 ENSMUST00000105661.9 Kiaa0720 NM_001285999 PKHG5_MOUSE Q66T00 Q66T02 Q6P3B1 Q6ZQ62 Q8R571 Syx uc008vzh.1 uc008vzh.2 uc008vzh.3 uc008vzh.4 This gene encodes a protein belonging to the Rho guanine exchange factor (GEF) family of proteins, which activate GTPases by replacing GDP with GTP. This family member is a RhoA GEF that plays a role in endothelial cell migration and tube formation. It is required for angiogenesis and may function in neuronal cell differentiation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]. Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (PubMed:29084947). Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis (PubMed:21543326). Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (By similarity). Interacts with GIPC1/synectin and RHOA. Cytoplasm Cytoplasm, perinuclear region Cell membrane Cell junction Cell projection, lamellipodium Note=Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions and at the cell membrane (PubMed:16467373). Localizes at cell-cell junctions in quiescent endothelial cells, and relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells (PubMed:21543326). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SYX1; IsoId=Q66T02-1; Sequence=Displayed; Name=2; Synonyms=SYX2; IsoId=Q66T02-2; Sequence=VSP_028587; Expressed in neurons and glial cells of the peripheral nervous system, with highest levels of expression in the brain and sciatic nerve endoneurium. Isoform 2 is expressed at detectable levels only in malignant cells. Regulated during development, with the highest level at postnatal days 10 to 14, suggesting a role in myelination of the peripheral nervous system. Animals develop normally and show no clear neurologic symptoms as adults. However, electrophysiologic studies indicated that mutant mice have decreased motor nerve conduction velocities and delayed compound action potentials. Mutant mice perform slightly less well than control mice in the rotarod test (PubMed:23777631). Deficient mice have no motoneuron loss during their first year. A loss of motoneurons starts at 12 months and this decrease is more prominent in 24-month-old animals. Biogenesis of autophagosomes is impaired in Plekhg5-deficient motoneurons resulting in a reduced number of retrogradely transported autophagosomes (PubMed:29084947). Sequence=CAM24581.1; Type=Erroneous gene model prediction; Evidence=; Rho guanyl-nucleotide exchange factor activity protein binding cytoplasm plasma membrane cell-cell junction membrane lamellipodium cell junction endocytic vesicle regulation of Rho protein signal transduction endothelial cell chemotaxis cell projection endothelial cell migration perinuclear region of cytoplasm presynapse regulation of protein catabolic process at presynapse, modulating synaptic transmission uc008vzh.1 uc008vzh.2 uc008vzh.3 uc008vzh.4 
ENSMUST00000105667.4 Gm13090 ENSMUST00000105667.4 Gm13090 (from geneSymbol) ENSMUST00000105667.1 ENSMUST00000105667.2 ENSMUST00000105667.3 uc057bsy.1 uc057bsy.2 uc057bsy.3 uc057bsy.1 uc057bsy.2 uc057bsy.3 
ENSMUST00000105675.8 Park7 ENSMUST00000105675.8 Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox- sensitive chaperone and protease (PubMed:15784737, PubMed:17015834, PubMed:20800516, PubMed:21068725). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:17015834, PubMed:21097510). Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. But this function is rebuted by other works. As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin. Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels. Displays a very low glyoxalase activity that may reflect its deglycase activity (PubMed:22523093). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:17766438). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:20186336). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:21068725). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046, PubMed:19276172). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (PubMed:26422139). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (By similarity). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (PubMed:26021615). (from UniProt Q99LX0) BC002187 ENSMUST00000105675.1 ENSMUST00000105675.2 ENSMUST00000105675.3 ENSMUST00000105675.4 ENSMUST00000105675.5 ENSMUST00000105675.6 ENSMUST00000105675.7 O88306 PARK7_MOUSE Park7 Q3THB9 Q3U509 Q99LX0 uc290sbc.1 uc290sbc.2 Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox- sensitive chaperone and protease (PubMed:15784737, PubMed:17015834, PubMed:20800516, PubMed:21068725). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:17015834, PubMed:21097510). Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. But this function is rebuted by other works. As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin. Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels. Displays a very low glyoxalase activity that may reflect its deglycase activity (PubMed:22523093). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:17766438). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:20186336). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:21068725). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046, PubMed:19276172). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (PubMed:26422139). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (By similarity). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (PubMed:26021615). Reaction=H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) + L-arginyl-[protein] + lactate; Xref=Rhea:RHEA:49548, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:12428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:29965, ChEBI:CHEBI:131708; EC=3.5.1.124; Evidence=; Reaction=H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) + L-lysyl-[protein] + lactate; Xref=Rhea:RHEA:49552, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:12429, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:29969, ChEBI:CHEBI:131709; EC=3.5.1.124; Evidence=; Reaction=H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate; Xref=Rhea:RHEA:49556, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:12430, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:29950, ChEBI:CHEBI:131710; EC=3.5.1.124; Evidence=; Reaction=H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] = glycolate + H(+) + L-arginyl-[protein]; Xref=Rhea:RHEA:57188, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:14844, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:29965, ChEBI:CHEBI:141553; EC=3.5.1.124; Evidence=; Reaction=H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] = glycolate + H(+) + L-lysyl-[protein]; Xref=Rhea:RHEA:57192, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:14845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:29969, ChEBI:CHEBI:141554; EC=3.5.1.124; Evidence=; Reaction=H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] = glycolate + H(+) + L-cysteinyl-[protein]; Xref=Rhea:RHEA:57196, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:14846, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:29950, ChEBI:CHEBI:141555; EC=3.5.1.124; Evidence=; Reaction=H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP = dGTP + H(+) + lactate; Xref=Rhea:RHEA:57244, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:61429, ChEBI:CHEBI:141569; Evidence=; Reaction=H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP = GTP + H(+) + lactate; Xref=Rhea:RHEA:57256, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:37565, ChEBI:CHEBI:141570; Evidence=; Reaction=H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP = GDP + H(+) + lactate; Xref=Rhea:RHEA:57260, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:58189, ChEBI:CHEBI:141573; Evidence=; Reaction=H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP = GMP + H(+) + lactate; Xref=Rhea:RHEA:57268, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:58115, ChEBI:CHEBI:141575; Evidence=; Reaction=H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP = dGTP + glycolate + H(+); Xref=Rhea:RHEA:57248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:61429, ChEBI:CHEBI:141572; Evidence=; Reaction=H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP = glycolate + GTP + H(+); Xref=Rhea:RHEA:57252, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:37565, ChEBI:CHEBI:141571; Evidence=; Reaction=H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP = GDP + glycolate + H(+); Xref=Rhea:RHEA:57264, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:58189, ChEBI:CHEBI:141574; Evidence=; Reaction=H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP = glycolate + GMP + H(+); Xref=Rhea:RHEA:57304, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:58115, ChEBI:CHEBI:141576; Evidence=; Reaction=an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O = a guanosine in RNA + H(+) + lactate; Xref=Rhea:RHEA:57288, Rhea:RHEA- COMP:14855, Rhea:RHEA-COMP:14858, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:74269, ChEBI:CHEBI:141580; Evidence=; Reaction=an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + H(+) + lactate; Xref=Rhea:RHEA:57300, Rhea:RHEA-COMP:11367, Rhea:RHEA-COMP:14856, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:85445, ChEBI:CHEBI:141578; Evidence=; Reaction=an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O = a guanosine in RNA + glycolate + H(+); Xref=Rhea:RHEA:57292, Rhea:RHEA- COMP:14855, Rhea:RHEA-COMP:14859, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:74269, ChEBI:CHEBI:141581; Evidence=; Reaction=an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + glycolate + H(+); Xref=Rhea:RHEA:57296, Rhea:RHEA-COMP:11367, Rhea:RHEA-COMP:14857, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:85445, ChEBI:CHEBI:141579; Evidence=; Note=Deglycase activity does not require glutathione as a cofactor, however, glycated glutathione constitutes a PARK7 substrate. ; Homodimer. Binds EFCAB6/DJBP and PIAS2. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR. Binds to HIPK1 (By similarity). Interacts (via N-terminus) with OTUD7B (PubMed:21097510). Interacts with BBS1, CLCF1 and MTERF (PubMed:21097510). Interacts (via C-terminus) with NCF1; the interaction is enhanced by LPS and modulates NCF1 phosphorylation and membrane translocation (PubMed:26021615). Interacts with NENF (PubMed:31536960). Cell membrane ; Lipid-anchor Cytoplasm Membrane raft Nucleus Mitochondrion Endoplasmic reticulum Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (By similarity). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation (PubMed:23847046). Expressed in erythroblasts and in mature red blood cells from peripheral blood (at protein level) (PubMed:20800516). In pancreas, expression is higher in islets than surrounding exocrine tissues (PubMed:22611253). Expression increases during erythroid development (at protein level) (PubMed:20800516). In pancreatic islets, expression increases during aging (PubMed:22611253). By hydrogen peroxide. Sumoylated on Lys-130 by PIAS2 or PIAS4; which is essential for cell-growth promoting activity and transforming activity. Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative stress. Increased sensitivity of embryonic cortical neurons to oxidative stress. Age-dependent increase in mitochondrial hydrogen peroxide production and reduced mitochondrial aconitase activity. Down-regulation of Slc25a14 and Slc25a27, compromised calcium-induced uncoupling and increased oxidation of mitochondrial matrix proteins specifically in the dopaminergic neurons of the substantia nigra pars compacta. Reduced N2el2 protein expression. Impaired mitochondrial function and morphology with reduced autophagy leading to accumulation of defective mitochondria. Targeted knockouts in astrocytes exhibit augmented LPS-induced CRK/p38 phosphorylation and signaling, they don't stimulate TLR4 endocytosis upon LPS stimulation. Knockout animals present increased bacterial burdens, reduced local and systemic inflammation, macrophage paralysis and impaired induction of pro-inflammatory cytokines, such as IL6 and TNF, under the condition of sepsis (PubMed:26021615). Mutants from 12 weeks old, but not younger, show higher levels of reactive oxygen species (ROS) and mitochondrial fragmentation in pancreatic islets. They have lower levels of plasma insulin after glucose challenge, display glucose intolerance and have reduced beta-cell area. Younger mutants kept on a high fat diet also show lower levels of plasma insulin, display glucose intolerance and have reduced beta-cell area (PubMed:22611253). Animals become diabetic upon multiple low doses of streptozotocin with reduced insulin concentrations, higher fasting blood glucose concentrations and higher rates of beta cell apoptosis compared to wild type (PubMed:26422139). Belongs to the peptidase C56 family. Glyoxalase activity has been reported (PubMed:22523093). It may however reflect its deglycase activity. The protein deglycation activity is controversial. It has been ascribed to a TRIS buffer artifact by a publication and as a result of the removal of methylglyoxal by glyoxalase activity that leads to a subsequent decomposition of hemithioacetals and hemianimals due to the shift in equilibrium position by another one. However, biochemical experiments showing that PARK7 is a bona fide deglycase have been performed. chromatin negative regulation of protein phosphorylation synaptic transmission, dopaminergic positive regulation of acute inflammatory response to antigenic stimulus transcription coactivator activity RNA binding mRNA binding receptor binding copper ion binding protein binding nucleus cytoplasm mitochondrion mitochondrial intermembrane space mitochondrial matrix endoplasmic reticulum cytosol plasma membrane DNA repair negative regulation of protein kinase activity proteolysis protein deglycosylation autophagy inflammatory response cellular response to DNA damage stimulus response to oxidative stress mitochondrion organization single fertilization transcription factor binding peptidase activity adult locomotory behavior detoxification of copper ion positive regulation of gene expression negative regulation of gene expression membrane superoxide dismutase copper chaperone activity PML body oxidoreductase activity, acting on peroxide as acceptor hydrolase activity enzyme active site formation via L-cysteine sulfinic acid lactate biosynthetic process enzyme binding kinase binding cytokine binding insulin secretion axon negative regulation of protein ubiquitination negative regulation of protein binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of interleukin-8 production positive regulation of peptidyl-serine phosphorylation negative regulation of protein sumoylation positive regulation of NAD(P)H oxidase activity cellular response to oxidative stress cellular response to reactive oxygen species tyrosine 3-monooxygenase activator activity cellular response to glyoxal L-dopa decarboxylase activator activity protein deglycase activity peptidyl-cysteine deglycation peptidyl-arginine deglycation peptidyl-lysine deglycation protein deglycation, glyoxal removal glutathione deglycation negative regulation of protein catabolic process response to hydrogen peroxide glucose homeostasis hydrogen peroxide metabolic process identical protein binding protein homodimerization activity neuron projection negative regulation of apoptotic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process cell body small protein activating enzyme binding ubiquitin-like protein conjugating enzyme binding macromolecular complex binding membrane raft mercury ion binding positive regulation of transcription from RNA polymerase II promoter glycolate biosynthetic process negative regulation of protein export from nucleus perinuclear region of cytoplasm androgen receptor binding regulation of inflammatory response detoxification of mercury ion protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of ubiquitin-protein transferase activity dopamine uptake involved in synaptic transmission regulation of mitochondrial membrane potential membrane depolarization peroxiredoxin activity membrane hyperpolarization negative regulation of cell death regulation of androgen receptor signaling pathway cellular response to hydrogen peroxide repressing transcription factor binding positive regulation of protein homodimerization activity scaffold protein binding presynapse cellular oxidant detoxification positive regulation of protein localization to nucleus negative regulation of neuron death positive regulation of superoxide dismutase activity negative regulation of protein acetylation positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of mitochondrial electron transport, NADH to ubiquinone negative regulation of protein K48-linked deubiquitination negative regulation of TRAIL-activated apoptotic signaling pathway cupric ion binding cuprous ion binding positive regulation of pyrroline-5-carboxylate reductase activity positive regulation of tyrosine 3-monooxygenase activity positive regulation of dopamine biosynthetic process glyoxal metabolic process positive regulation of L-dopa biosynthetic process positive regulation of L-dopa decarboxylase activity negative regulation of oxidative stress-induced cell death negative regulation of oxidative stress-induced neuron death negative regulation of hydrogen peroxide-induced cell death negative regulation of hydrogen peroxide-induced neuron death negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway negative regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species biosynthetic process negative regulation of NMDA glutamate receptor activity negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway positive regulation of fertilization ubiquitin-specific protease binding negative regulation of ubiquitin-specific protease activity positive regulation of oxidative phosphorylation uncoupler activity positive regulation of transcription regulatory region DNA binding positive regulation of androgen receptor activity negative regulation of extrinsic apoptotic signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway methylglyoxal metabolic process protein deglycation, methylglyoxal removal uc290sbc.1 uc290sbc.2 
ENSMUST00000105682.9 Rere ENSMUST00000105682.9 arginine glutamic acid dipeptide (RE) repeats (from RefSeq NM_001085492.1) A2A7T4 Atr2 ENSMUST00000105682.1 ENSMUST00000105682.2 ENSMUST00000105682.3 ENSMUST00000105682.4 ENSMUST00000105682.5 ENSMUST00000105682.6 ENSMUST00000105682.7 ENSMUST00000105682.8 Kiaa0458 NM_001085492 Q80TZ9 RERE_MOUSE uc008vxr.1 uc008vxr.2 uc008vxr.3 Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Interacts with HDAC1 and ATN1. Interaction with ATN1 is improved when the poly-Gln region of ATN1 is extended. Interacts with FAT1 (By similarity). Nucleus, PML body Note=Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs (By similarity). At 8.25 dpc expression is strongly elevated in the anterior midline. At 8.5 dpc expression is elevated throughout the anteroposterior extent of the notochord and is down-regulated in the heart. At 8.75 dpc expression is increased in the ventral brain. At 9.5 dpc strong expression appears besides the notochord including the apical ectodermal ridge (AER), the isthmus and the ventral diencephalon. At 10.5 dpc expression increases in the notochord, the AER and spinal and brain neurons. The interaction with ATN1 is mediated by the coiled domain. Mice embryos exhibit a variety of patterning defects that first appear at 8.0 dpc. Defects include a specific failure in ventralization of the anterior neural plate, loss of heart looping and irregular partitioning of somites. In mutant embryos, Shh expression fails to initiate along the anterior midline at 8.0 dpc, and Fgf8 is delocalized from the anterior neural ridge at 8.5 dpc. histone deacetylase complex RNA polymerase II transcription factor binding DNA binding chromatin binding transcription coactivator activity transcription corepressor activity protein binding nucleus chromatin remodeling regulation of transcription, DNA-templated multicellular organism development zinc ion binding PML body cerebellum development cerebellar Purkinje cell layer maturation cerebellar granule cell precursor proliferation radial glia guided migration of Purkinje cell sequence-specific DNA binding metal ion binding branching morphogenesis of a nerve dendrite morphogenesis negative regulation of nucleic acid-templated transcription positive regulation of nucleic acid-templated transcription uc008vxr.1 uc008vxr.2 uc008vxr.3 
ENSMUST00000105686.3 Slc25a33 ENSMUST00000105686.3 solute carrier family 25, member 33 (from RefSeq NM_027460.2) ENSMUST00000105686.1 ENSMUST00000105686.2 NM_027460 Q3TZX3 Q921P8 Q9CYJ1 S2533_MOUSE uc008vxe.1 uc008vxe.2 uc008vxe.3 Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (By similarity). May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (By similarity). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (By similarity). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:17596519). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (By similarity). Reaction=UDP(out) + UTP(in) = UDP(in) + UTP(out); Xref=Rhea:RHEA:73515, ChEBI:CHEBI:46398, ChEBI:CHEBI:58223; Evidence=; Reaction=dUTP(out) + UTP(in) = dUTP(in) + UTP(out); Xref=Rhea:RHEA:73519, ChEBI:CHEBI:46398, ChEBI:CHEBI:61555; Evidence=; Reaction=TTP(out) + UTP(in) = TTP(in) + UTP(out); Xref=Rhea:RHEA:73523, ChEBI:CHEBI:46398, ChEBI:CHEBI:63527; Evidence=; Reaction=TDP(out) + UTP(in) = TDP(in) + UTP(out); Xref=Rhea:RHEA:73527, ChEBI:CHEBI:46398, ChEBI:CHEBI:61417; Evidence=; Reaction=CTP(out) + UTP(in) = CTP(in) + UTP(out); Xref=Rhea:RHEA:73531, ChEBI:CHEBI:37563, ChEBI:CHEBI:46398; Evidence=; Reaction=CDP(out) + UTP(in) = CDP(in) + UTP(out); Xref=Rhea:RHEA:73535, ChEBI:CHEBI:46398, ChEBI:CHEBI:58069; Evidence=; Reaction=dCTP(out) + UTP(in) = dCTP(in) + UTP(out); Xref=Rhea:RHEA:73539, ChEBI:CHEBI:46398, ChEBI:CHEBI:61481; Evidence=; Reaction=dCDP(out) + UTP(in) = dCDP(in) + UTP(out); Xref=Rhea:RHEA:73543, ChEBI:CHEBI:46398, ChEBI:CHEBI:58593; Evidence=; Reaction=GTP(out) + UTP(in) = GTP(in) + UTP(out); Xref=Rhea:RHEA:73547, ChEBI:CHEBI:37565, ChEBI:CHEBI:46398; Evidence=; Reaction=GDP(out) + UTP(in) = GDP(in) + UTP(out); Xref=Rhea:RHEA:73551, ChEBI:CHEBI:46398, ChEBI:CHEBI:58189; Evidence=; Reaction=dGTP(out) + UTP(in) = dGTP(in) + UTP(out); Xref=Rhea:RHEA:73559, ChEBI:CHEBI:46398, ChEBI:CHEBI:61429; Evidence=; Reaction=dGDP(out) + UTP(in) = dGDP(in) + UTP(out); Xref=Rhea:RHEA:73563, ChEBI:CHEBI:46398, ChEBI:CHEBI:58595; Evidence=; Reaction=ITP(out) + UTP(in) = ITP(in) + UTP(out); Xref=Rhea:RHEA:73567, ChEBI:CHEBI:46398, ChEBI:CHEBI:61402; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. Sequence=BAB30846.1; Type=Frameshift; Evidence=; mitochondrial genome maintenance regulation of oxidative phosphorylation mitochondrion mitochondrial inner membrane transcription from mitochondrial promoter pyrimidine nucleotide transport mitochondrion organization positive regulation of cell proliferation pyrimidine nucleotide transmembrane transporter activity membrane integral component of membrane positive regulation of cell growth mitochondria-nucleus signaling pathway mitochondrial membrane cellular response to insulin stimulus mitochondrial respiratory chain complex III assembly regulation of mitochondrial membrane potential regulation of cell cycle arrest regulation of reactive oxygen species biosynthetic process cellular response to insulin-like growth factor stimulus mitochondrial pyrimidine nucleotide import uc008vxe.1 uc008vxe.2 uc008vxe.3 
ENSMUST00000105687.9 Tmem201 ENSMUST00000105687.9 transmembrane protein 201, transcript variant 12 (from RefSeq NR_189668.1) A2A8U2 D4Ertd429e ENSMUST00000105687.1 ENSMUST00000105687.2 ENSMUST00000105687.3 ENSMUST00000105687.4 ENSMUST00000105687.5 ENSMUST00000105687.6 ENSMUST00000105687.7 ENSMUST00000105687.8 NR_189668 Net5 Q3U5F3 Q6GQS9 Q8BNY3 Samp1 TM201_MOUSE uc008vwz.1 uc008vwz.2 uc008vwz.3 uc008vwz.4 Involved in nuclear movement during fibroblast polarization and migration (PubMed:22349700). May recruit Ran GTPase to the nuclear periphery (By similarity). [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle. Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina. [Isoform 3]: Proposed to be involved in actin-dependent nuclear movement; via SUN2 associates with transmembrane actin- associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow. Isoform 2 interacts with EMD (By similarity). Isoform 3 interacts with SUN2 and LMNA (PubMed:22349700). May bind to Ran GTPase; has a greater affinity for Ran-GTP over Ran-GDP (By similarity). A2A8U2-3; Q8BJS4: Sun2; NbExp=3; IntAct=EBI-12591474, EBI-646914; [Isoform 2]: Nucleus inner membrane ; Multi-pass membrane protein Note=The C-terminal of isoform 2 is located on the nucleoplasmic side. During interphase, isoform 2 is distributed in the inner nuclear membrane and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Samp1c; IsoId=A2A8U2-1; Sequence=Displayed; Name=2; Synonyms=Samp1, Samp1a; IsoId=A2A8U2-2; Sequence=VSP_030917, VSP_030918; Name=3; Synonyms=Samp1b; IsoId=A2A8U2-3; Sequence=VSP_030919, VSP_030920; Belongs to the TMEM201 family. protein binding lamin binding nucleus nuclear envelope nuclear inner membrane integral component of nuclear inner membrane nuclear envelope organization nuclear migration fibroblast migration membrane integral component of membrane nuclear migration along microtubule nuclear membrane actin filament binding centrosome localization protein localization to nuclear envelope spindle pole centrosome cortical endoplasmic reticulum uc008vwz.1 uc008vwz.2 uc008vwz.3 uc008vwz.4 
ENSMUST00000105718.8 Zfp933 ENSMUST00000105718.8 zinc finger protein 933, transcript variant 1 (from RefSeq NM_198619.3) 2810408P10Rik ENSMUST00000105718.1 ENSMUST00000105718.2 ENSMUST00000105718.3 ENSMUST00000105718.4 ENSMUST00000105718.5 ENSMUST00000105718.6 ENSMUST00000105718.7 NM_198619 Q6PEE4 Q6PEE4_MOUSE Zfp933 uc008vtc.1 uc008vtc.2 uc008vtc.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc008vtc.1 uc008vtc.2 uc008vtc.3 
ENSMUST00000105720.8 Zfp979 ENSMUST00000105720.8 Zfp979 (from geneSymbol) A2A799 A2A799_MOUSE BC058858 ENSMUST00000105720.1 ENSMUST00000105720.2 ENSMUST00000105720.3 ENSMUST00000105720.4 ENSMUST00000105720.5 ENSMUST00000105720.6 ENSMUST00000105720.7 Zfp979 uc290rsn.1 uc290rsn.2 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc290rsn.1 uc290rsn.2 
ENSMUST00000105721.9 Zfp982 ENSMUST00000105721.9 zinc finger protein 982, transcript variant 1 (from RefSeq NM_001365422.2) A2A8Q4 A2A8Q4_MOUSE ENSMUST00000105721.1 ENSMUST00000105721.2 ENSMUST00000105721.3 ENSMUST00000105721.4 ENSMUST00000105721.5 ENSMUST00000105721.6 ENSMUST00000105721.7 ENSMUST00000105721.8 NM_001365422 Zfp982 uc290rsf.1 uc290rsf.2 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290rsf.1 uc290rsf.2 
ENSMUST00000105733.3 Zfp992 ENSMUST00000105733.3 zinc finger protein 992 (from RefSeq NM_001085522.2) B1ASD8 B1ASD8_MOUSE ENSMUST00000105733.1 ENSMUST00000105733.2 NM_001085522 Zfp992 uc057lkx.1 uc057lkx.2 uc057lkx.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc057lkx.1 uc057lkx.2 uc057lkx.3 
ENSMUST00000105734.10 Zfp984 ENSMUST00000105734.10 zinc finger protein 984 (from RefSeq NM_001127189.3) A2A7A2 A2A7A2_MOUSE ENSMUST00000105734.1 ENSMUST00000105734.2 ENSMUST00000105734.3 ENSMUST00000105734.4 ENSMUST00000105734.5 ENSMUST00000105734.6 ENSMUST00000105734.7 ENSMUST00000105734.8 ENSMUST00000105734.9 NM_001127189 Zfp984 uc012dpf.1 uc012dpf.2 uc012dpf.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc012dpf.1 uc012dpf.2 uc012dpf.3 
ENSMUST00000105735.9 Zfp981 ENSMUST00000105735.9 zinc finger protein 981, transcript variant 1 (from RefSeq NM_001243138.1) A2A8V7 A2A8V7_MOUSE ENSMUST00000105735.1 ENSMUST00000105735.2 ENSMUST00000105735.3 ENSMUST00000105735.4 ENSMUST00000105735.5 ENSMUST00000105735.6 ENSMUST00000105735.7 ENSMUST00000105735.8 NM_001243138 Zfp981 uc029var.1 uc029var.2 uc029var.3 May be involved in transcriptional regulation. Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc029var.1 uc029var.2 uc029var.3 
ENSMUST00000105738.9 Zfp980 ENSMUST00000105738.9 zinc finger protein 980 (from RefSeq NM_001103158.2) A2A9J5 A2A9J5_MOUSE ENSMUST00000105738.1 ENSMUST00000105738.2 ENSMUST00000105738.3 ENSMUST00000105738.4 ENSMUST00000105738.5 ENSMUST00000105738.6 ENSMUST00000105738.7 ENSMUST00000105738.8 NM_001103158 Zfp980 uc008vsb.1 uc008vsb.2 uc008vsb.3 Nucleus hematopoietic progenitor cell differentiation nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc008vsb.1 uc008vsb.2 uc008vsb.3 
ENSMUST00000105739.8 Zfp268 ENSMUST00000105739.8 zinc finger protein 268 (from RefSeq NM_001324416.1) B1ASQ7 B1ASQ7_MOUSE ENSMUST00000105739.1 ENSMUST00000105739.2 ENSMUST00000105739.3 ENSMUST00000105739.4 ENSMUST00000105739.5 ENSMUST00000105739.6 ENSMUST00000105739.7 NM_001324416 Zfp268 uc290rpg.1 uc290rpg.2 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc290rpg.1 uc290rpg.2 
ENSMUST00000105742.8 Zfp990 ENSMUST00000105742.8 zinc finger protein 990 (from RefSeq NM_001324553.1) B1AVN5 B1AVN5_MOUSE ENSMUST00000105742.1 ENSMUST00000105742.2 ENSMUST00000105742.3 ENSMUST00000105742.4 ENSMUST00000105742.5 ENSMUST00000105742.6 ENSMUST00000105742.7 NM_001324553 Zfp990 uc057lku.1 uc057lku.2 uc057lku.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc057lku.1 uc057lku.2 uc057lku.3 
ENSMUST00000105746.3 Aadacl4fm5 ENSMUST00000105746.3 AADACL4 family member 5 (from RefSeq NM_001126316.1) Aadacl4fm5 B1ASB3 B1ASB3_MOUSE ENSMUST00000105746.1 ENSMUST00000105746.2 Gm438 NM_001126316 uc012dou.1 uc012dou.2 cellular_component catabolic process membrane integral component of membrane hydrolase activity short-chain carboxylesterase activity uc012dou.1 uc012dou.2 
ENSMUST00000105747.2 Aadacl4fm4 ENSMUST00000105747.2 AADACL4 family member 4 (from RefSeq NM_001085504.1) Aadacl4fm4 B1AVU6 B1AVU6_MOUSE ENSMUST00000105747.1 Gm436 NM_001085504 uc008vrk.1 uc008vrk.2 cellular_component catabolic process hydrolase activity short-chain carboxylesterase activity uc008vrk.1 uc008vrk.2 
ENSMUST00000105748.2 Aadacl4fm2 ENSMUST00000105748.2 AADACL4 family member 2 (from RefSeq NM_001085542.1) A2A752 A2A752_MOUSE Aadacl4fm2 ENSMUST00000105748.1 Gm13124 NM_001085542 uc008vri.1 uc008vri.2 cellular_component catabolic process hydrolase activity short-chain carboxylesterase activity uc008vri.1 uc008vri.2 
ENSMUST00000105749.2 Aadacl3 ENSMUST00000105749.2 arylacetamide deacetylase like 3 (from RefSeq NM_001085503.2) A2A7Z8 ADCL3_MOUSE ENSMUST00000105749.1 NM_001085503 uc008vrg.1 uc008vrg.2 Membrane ; Multi-pass membrane protein Belongs to the 'GDXG' lipolytic enzyme family. cellular_component catabolic process membrane integral component of membrane hydrolase activity short-chain carboxylesterase activity carboxylic ester hydrolase activity uc008vrg.1 uc008vrg.2 
ENSMUST00000105751.3 Pramel30 ENSMUST00000105751.3 PRAME like 30 (from RefSeq NM_001085541.1) ENSMUST00000105751.1 ENSMUST00000105751.2 L7MU96 L7MU96_MOUSE NM_001085541 Pramel30 uc008vrb.1 uc008vrb.2 uc008vrb.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vrb.1 uc008vrb.2 uc008vrb.3 
ENSMUST00000105757.8 Pramel29 ENSMUST00000105757.8 PRAME like 29 (from RefSeq NM_001177542.1) A2A958 A2A958_MOUSE ENSMUST00000105757.1 ENSMUST00000105757.2 ENSMUST00000105757.3 ENSMUST00000105757.4 ENSMUST00000105757.5 ENSMUST00000105757.6 ENSMUST00000105757.7 NM_001177542 Pramel29 uc008vqz.1 uc008vqz.2 uc008vqz.3 uc008vqz.4 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vqz.1 uc008vqz.2 uc008vqz.3 uc008vqz.4 
ENSMUST00000105760.3 Gm17151 ENSMUST00000105760.3 Gm17151 (from geneSymbol) ENSMUST00000105760.1 ENSMUST00000105760.2 uc287tcs.1 uc287tcs.2 uc287tcs.1 uc287tcs.2 
ENSMUST00000105762.3 Pramel14 ENSMUST00000105762.3 PRAME like 14 (from RefSeq NM_001085540.2) A2ASJ1 A2ASJ1_MOUSE ENSMUST00000105762.1 ENSMUST00000105762.2 Gm13128 NM_001085540 Pramel14 uc008vqr.1 uc008vqr.2 uc008vqr.3 uc008vqr.4 uc008vqr.5 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vqr.1 uc008vqr.2 uc008vqr.3 uc008vqr.4 uc008vqr.5 
ENSMUST00000105763.3 Pramel28 ENSMUST00000105763.3 Belongs to the PRAME family. (from UniProt A2ASJ0) A2ASJ0 A2ASJ0_MOUSE ENSMUST00000105763.1 ENSMUST00000105763.2 Pramel28 uc290rmt.1 uc290rmt.2 uc290rmt.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290rmt.1 uc290rmt.2 uc290rmt.3 
ENSMUST00000105766.3 Pramel16 ENSMUST00000105766.3 PRAME like 16, transcript variant 3 (from RefSeq NM_001406700.1) A2ASI9 A2ASI9_MOUSE ENSMUST00000105766.1 ENSMUST00000105766.2 Gm13101 NM_001406700 Pramel16 uc012dor.1 uc012dor.2 uc012dor.3 uc012dor.4 uc012dor.5 uc012dor.6 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc012dor.1 uc012dor.2 uc012dor.3 uc012dor.4 uc012dor.5 uc012dor.6 
ENSMUST00000105767.3 Pramel11 ENSMUST00000105767.3 PRAME like 11, transcript variant 1 (from RefSeq NM_001406740.1) A2A8M8 A2A8M8_MOUSE ENSMUST00000105767.1 ENSMUST00000105767.2 NM_001406740 Pramel11 uc290rmq.1 uc290rmq.2 uc290rmq.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290rmq.1 uc290rmq.2 uc290rmq.3 
ENSMUST00000105771.3 Pramel22 ENSMUST00000105771.3 PRAME like 22 (from RefSeq NM_001126325.1) A2AGW6 A2AGW6_MOUSE ENSMUST00000105771.1 ENSMUST00000105771.2 NM_001126325 Pramel22 uc012dop.1 uc012dop.2 uc012dop.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc012dop.1 uc012dop.2 uc012dop.3 
ENSMUST00000105773.3 Pramel21 ENSMUST00000105773.3 PRAME like 21 (from RefSeq NM_001126324.2) A2AGW5 A2AGW5_MOUSE ENSMUST00000105773.1 ENSMUST00000105773.2 NM_001126324 Pramel21 uc012doo.1 uc012doo.2 uc012doo.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc012doo.1 uc012doo.2 uc012doo.3 
ENSMUST00000105774.2 Pramel20 ENSMUST00000105774.2 PRAME like 20 (from RefSeq NM_001007579.3) BC080695 D3Z635 ENSMUST00000105774.1 NM_001007579 Pramel20 Q66JY9 Q66JY9_MOUSE uc008vqi.1 uc008vqi.2 uc008vqi.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vqi.1 uc008vqi.2 uc008vqi.3 
ENSMUST00000105776.4 Gm13057 ENSMUST00000105776.4 predicted gene 13057 (from RefSeq NM_001113735.1) ENSMUST00000105776.1 ENSMUST00000105776.2 ENSMUST00000105776.3 Gm13040 Gm13043 Gm13057 NM_001113735 OTTMUSG00000010136 Q4FZF9 Q4FZF9_MOUSE uc012don.1 uc012don.2 uc012don.3 uc012don.4 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc012don.1 uc012don.2 uc012don.3 uc012don.4 
ENSMUST00000105778.8 Prdm2 ENSMUST00000105778.8 PR domain containing 2, with ZNF domain, transcript variant 2 (from RefSeq NM_001256380.1) A2A7B5 A2A7B5_MOUSE ENSMUST00000105778.1 ENSMUST00000105778.2 ENSMUST00000105778.3 ENSMUST00000105778.4 ENSMUST00000105778.5 ENSMUST00000105778.6 ENSMUST00000105778.7 NM_001256380 Prdm2 uc012doh.1 uc012doh.2 uc012doh.3 RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus Golgi apparatus regulation of transcription, DNA-templated determination of adult lifespan chromatin DNA binding response to estradiol sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding uc012doh.1 uc012doh.2 uc012doh.3 
ENSMUST00000105780.8 Fhad1 ENSMUST00000105780.8 Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A6PWD2-1; Sequence=Displayed; Name=2; IsoId=A6PWD2-2; Sequence=VSP_035371, VSP_035375, VSP_035376, VSP_035377; Name=3; IsoId=A6PWD2-3; Sequence=VSP_035373, VSP_035374; Name=4; IsoId=A6PWD2-4; Sequence=VSP_035372; Name=5; IsoId=A6PWD2-5; Sequence=VSP_035370, VSP_035376, VSP_035377; (from UniProt A6PWD2) A2AAC3 A6PWD2 AK045799 ENSMUST00000105780.1 ENSMUST00000105780.2 ENSMUST00000105780.3 ENSMUST00000105780.4 ENSMUST00000105780.5 ENSMUST00000105780.6 ENSMUST00000105780.7 FHAD1_MOUSE Q3UFH8 Q8BLA4 Q8CHV8 Q9CUV2 uc012dog.1 uc012dog.2 uc012dog.3 uc012dog.4 Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A6PWD2-1; Sequence=Displayed; Name=2; IsoId=A6PWD2-2; Sequence=VSP_035371, VSP_035375, VSP_035376, VSP_035377; Name=3; IsoId=A6PWD2-3; Sequence=VSP_035373, VSP_035374; Name=4; IsoId=A6PWD2-4; Sequence=VSP_035372; Name=5; IsoId=A6PWD2-5; Sequence=VSP_035370, VSP_035376, VSP_035377; molecular_function cellular_component biological_process uc012dog.1 uc012dog.2 uc012dog.3 uc012dog.4 
ENSMUST00000105785.9 Fblim1 ENSMUST00000105785.9 filamin binding LIM protein 1, transcript variant 2 (from RefSeq NM_133754.6) Cal ENSMUST00000105785.1 ENSMUST00000105785.2 ENSMUST00000105785.3 ENSMUST00000105785.4 ENSMUST00000105785.5 ENSMUST00000105785.6 ENSMUST00000105785.7 ENSMUST00000105785.8 FBLI1_MOUSE NM_133754 Q3TDK3 Q71FD7 Q99J35 uc008vos.1 uc008vos.2 uc008vos.3 Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). Interacts with FERMT2, FLNA, FLNB and FLNC (By similarity). Interacts with NKX2-5. Q71FD7; P52952: NKX2-5; Xeno; NbExp=4; IntAct=EBI-8346526, EBI-936601; Cell junction, focal adhesion Cytoplasm, cytoskeleton, stress fiber Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. Recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2. fibrillar center stress fiber cytoplasm cytoskeleton focal adhesion cell adhesion regulation of cell shape cell junction filamin binding regulation of integrin activation metal ion binding cell-cell adhesion uc008vos.1 uc008vos.2 uc008vos.3 
ENSMUST00000105786.3 Spen ENSMUST00000105786.3 spen family transcription repressor, transcript variant 1 (from RefSeq NM_019763.2) A2ADB0 A2ADB0_MOUSE ENSMUST00000105786.1 ENSMUST00000105786.2 NM_019763 Spen uc008von.1 uc008von.2 Belongs to the RRM Spen family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding nucleic acid binding transcription corepressor activity RNA binding nucleoplasm transcriptional repressor complex negative regulation of transcription, DNA-templated positive regulation of neurogenesis uc008von.1 uc008von.2 
ENSMUST00000105802.8 Htr6 ENSMUST00000105802.8 5-hydroxytryptamine (serotonin) receptor 6 (from RefSeq NM_001377096.1) 5HT6R_MOUSE ENSMUST00000105802.1 ENSMUST00000105802.2 ENSMUST00000105802.3 ENSMUST00000105802.4 ENSMUST00000105802.5 ENSMUST00000105802.6 ENSMUST00000105802.7 NM_001377096 Q9R1C8 uc290rdt.1 uc290rdt.2 This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (PubMed:25078650). Is an activator of TOR signaling (PubMed:23027611). Interacts with CDK5 (PubMed:25078650). Interacts with MTOR (PubMed:23027611). Interacts with RPTOR and NF1 (By similarity). Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity G-protein coupled serotonin receptor activity protein binding plasma membrane integral component of plasma membrane cilium signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission learning negative regulation of glutamate secretion negative regulation of gamma-aminobutyric acid secretion positive regulation of gamma-aminobutyric acid secretion negative regulation of acetylcholine secretion, neurotransmission membrane integral component of membrane cerebral cortex cell migration dendrite neurotransmitter receptor activity positive regulation of TOR signaling positive regulation of dopamine secretion long-term synaptic potentiation uc290rdt.1 uc290rdt.2 
ENSMUST00000105805.2 Gm13030 ENSMUST00000105805.2 predicted gene 13030 (from RefSeq NM_001308487.1) A2APQ6 A2APQ6_MOUSE ENSMUST00000105805.1 Gm13030 NM_001308487 uc057bsw.1 uc057bsw.2 molecular_function cellular_component biological_process uc057bsw.1 uc057bsw.2 
ENSMUST00000105808.8 Pla2g2c ENSMUST00000105808.8 Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; (from UniProt A2APR1) A2APR1 A2APR1_MOUSE BC029347 ENSMUST00000105808.1 ENSMUST00000105808.2 ENSMUST00000105808.3 ENSMUST00000105808.4 ENSMUST00000105808.5 ENSMUST00000105808.6 ENSMUST00000105808.7 Pla2g2c uc290rdc.1 uc290rdc.2 Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Secreted Belongs to the phospholipase A2 family. phospholipase A2 activity calcium ion binding extracellular region lipid metabolic process phospholipid metabolic process lipid catabolic process hydrolase activity arachidonic acid secretion uc290rdc.1 uc290rdc.2 
ENSMUST00000105810.8 Ubxn10 ENSMUST00000105810.8 UBX domain protein 10, transcript variant 3 (from RefSeq NM_001285929.1) ENSMUST00000105810.1 ENSMUST00000105810.2 ENSMUST00000105810.3 ENSMUST00000105810.4 ENSMUST00000105810.5 ENSMUST00000105810.6 ENSMUST00000105810.7 NM_001285929 Q3TTR1 Q8BG34 Q8BP58 Q8R0B6 UBX10_MOUSE Ubxd3 Ubxn10 uc008vld.1 uc008vld.2 uc008vld.3 uc008vld.4 VCP/p97-binding protein required for ciliogenesis. Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia. UBX domain- containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97. Interacts with CLUAP1; the interaction is direct and mediates interaction with the intraflagellar transport complex B (IFT-B). Interacts with VCP; the interaction is direct. Cell projection, cilium Note=Recruited to cilia in a VCP- dependent manner. Belongs to the UBXN10 family. molecular_function cilium cell projection organization intraciliary transport particle B cell projection cilium assembly uc008vld.1 uc008vld.2 uc008vld.3 uc008vld.4 
ENSMUST00000105824.8 Sh2d5 ENSMUST00000105824.8 SH2 domain containing 5 (from RefSeq NM_001099631.1) ENSMUST00000105824.1 ENSMUST00000105824.2 ENSMUST00000105824.3 ENSMUST00000105824.4 ENSMUST00000105824.5 ENSMUST00000105824.6 ENSMUST00000105824.7 NM_001099631 Q8JZW5 SH2D5_MOUSE Sh2d5 uc008vkm.1 uc008vkm.2 uc008vkm.3 May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. Interacts with BCR. Q8JZW5; P11274: BCR; Xeno; NbExp=2; IntAct=EBI-15101675, EBI-712838; Postsynaptic density Highly expressed in brain, particularly in Purkinjie cells in the cerebellum and the cornu ammonis of the hippocampus. Sequence=AAH36961.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding plasma membrane biological_process postsynaptic density membrane cell junction synapse postsynaptic membrane uc008vkm.1 uc008vkm.2 uc008vkm.3 
ENSMUST00000105840.8 Usp48 ENSMUST00000105840.8 ubiquitin specific peptidase 48, transcript variant 17 (from RefSeq NR_175978.1) A2ALR9 A2ALR9_MOUSE ENSMUST00000105840.1 ENSMUST00000105840.2 ENSMUST00000105840.3 ENSMUST00000105840.4 ENSMUST00000105840.5 ENSMUST00000105840.6 ENSMUST00000105840.7 NR_175978 Usp48 uc057lkm.1 uc057lkm.2 uc057lkm.3 Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Nucleus thiol-dependent ubiquitin-specific protease activity ubiquitin-dependent protein catabolic process protein deubiquitination thiol-dependent ubiquitinyl hydrolase activity uc057lkm.1 uc057lkm.2 uc057lkm.3 
ENSMUST00000105845.9 Ephb2 ENSMUST00000105845.9 Eph receptor B2, transcript variant 2 (from RefSeq NM_010142.4) A3KG00 A3KG01 A3KG02 A3KG89 A3KG90 ENSMUST00000105845.1 ENSMUST00000105845.2 ENSMUST00000105845.3 ENSMUST00000105845.4 ENSMUST00000105845.5 ENSMUST00000105845.6 ENSMUST00000105845.7 ENSMUST00000105845.8 EPHB2_MOUSE Ephb2 Epth3 NM_010142 Nuk P54763 Q62213 Q6GTQ7 Q6P5F1 Q9QVY4 Sek3 uc008vim.1 uc008vim.2 uc008vim.3 uc008vim.4 uc008vim.5 uc008vim.6 This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors consist of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. The encoded receptor preferentially binds membrane-bound ephrin-B ligands and is involved in nervous system and vascular development. This gene is used as a marker of intestinal stem cells. Homozygous knockout mice for this gene exhibit impaired axon guidance and vestibular function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Heterotetramer upon binding of the ligand (PubMed:11780069). The heterotetramer is composed of an ephrin dimer and a receptor dimer (PubMed:11780069). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (PubMed:9883737). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome (PubMed:21029865). Interacts with AQP1; involved in endolymph production in the inner ear (PubMed:10839360). Interacts with EFNA5 (PubMed:15107857). Interacts with SPSB1 (By similarity). Interacts with SPSB4 (PubMed:28931592). Interacts with SH2D3C (PubMed:10542222). P54763; PRO_0000000118 [P12023]: App; NbExp=4; IntAct=EBI-537711, EBI-14022231; P54763; Q5FWH6-2: Arhgef15; NbExp=3; IntAct=EBI-537711, EBI-2943608; P54763; Q03137: Epha4; NbExp=3; IntAct=EBI-537711, EBI-1539152; P54763; P54763: Ephb2; NbExp=2; IntAct=EBI-537711, EBI-537711; P54763; Q925T6: Grip1; NbExp=2; IntAct=EBI-537711, EBI-537752; P54763; P34152: Ptk2; NbExp=3; IntAct=EBI-537711, EBI-77070; P54763; P05480: Src; NbExp=3; IntAct=EBI-537711, EBI-298680; P54763; Q13009: TIAM1; Xeno; NbExp=3; IntAct=EBI-537711, EBI-1050007; Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Event=Alternative splicing; Named isoforms=3; Name=3 ; IsoId=P54763-3; Sequence=Displayed; Name=2 ; IsoId=P54763-2; Sequence=VSP_057933; Name=4 ; IsoId=P54763-4; Sequence=VSP_057932; Expressed in the epithelial dark cells of the inner ear. Expressed in the region of the proximal tubules of the kidney nephron. Expressed in myogenic progenitor cells (PubMed:27446912). Highly expressed in ventral cells of the neural tube and within axons of the peripheral nervous system during development. Expressed in the vestibulo-acoustic system and hindbrain as early as 11.5 dpc. Detected in the spinal cord at 12 dpc. Expressed in cells of the developing outer retina. Also expressed in mesenchyme adjacent to vessels. In myogenic progenitor cells, highly expressed during early development (11.5 dpc) and progressively repressed as developments proceeds (PubMed:27446912). Autophosphorylated; ligand binding stimulates autophosphorylation on tyrosine residues. Ligand binding induces cleavage by matrix metalloproteinases (MMPs) such as MMP7/MMP9, producing an EphB2/N-terminal fragment (NTF) and a C-terminal long fragment (EphB2-LF). EphB2-LF is further cleaved by MMPs, producing EphB2/CTF1 which is further cleaved by the PS1/gamma-secretase producing EphB2/CTF2. Polyubiquitinated; ligand binding stimulates ubiquitination (PubMed:17428795, PubMed:28931592). Ubiquitinated by RNF186 at Lys-891, mainly through 'Lys-27'-linked polyubiquitin chains (By similarity). Mice are long-lived and fertile. They display strain-specific circling behavior, are hyperactive and exhibit rapid head bobbing and twirled excessively when picked-up by the tail. This is probably due to abnormal vestibular function. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Sequence=AAA72411.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH62924.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding cell morphogenesis angiogenesis beta-amyloid binding urogenital system development negative regulation of protein phosphorylation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity transmembrane-ephrin receptor activity receptor binding protein binding ATP binding nucleus plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development axon guidance axonal fasciculation learning or memory learning axon guidance receptor activity animal organ morphogenesis positive regulation of gene expression membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation optic nerve morphogenesis central nervous system projection neuron axonogenesis corpus callosum development axon dendrite retinal ganglion cell axon guidance positive regulation of synaptic plasticity signaling receptor activity inner ear morphogenesis identical protein binding cell projection neuronal cell body receptor complex macromolecular complex binding synapse negative regulation of Ras protein signal transduction ephrin receptor signaling pathway regulation of neuronal synaptic plasticity positive regulation of long-term neuronal synaptic plasticity camera-type eye morphogenesis regulation of axonogenesis negative regulation of axonogenesis regulation of body fluid levels inactivation of MAPKK activity regulation of synapse assembly positive regulation of synapse assembly palate development dendritic spine development dendritic spine morphogenesis negative regulation of ERK1 and ERK2 cascade commissural neuron axon guidance postsynaptic membrane assembly glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission positive regulation of long-term synaptic potentiation positive regulation of protein localization to plasma membrane negative regulation of NMDA glutamate receptor activity positive regulation of NMDA glutamate receptor activity uc008vim.1 uc008vim.2 uc008vim.3 uc008vim.4 uc008vim.5 uc008vim.6 
ENSMUST00000105849.9 Luzp1 ENSMUST00000105849.9 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Note=Also detected in soma and dendrites of neurons. (from UniProt Q8R4U7) A3KG96 ENSMUST00000105849.1 ENSMUST00000105849.2 ENSMUST00000105849.3 ENSMUST00000105849.4 ENSMUST00000105849.5 ENSMUST00000105849.6 ENSMUST00000105849.7 ENSMUST00000105849.8 L49344 LUZP1_MOUSE Luzp Q3UV18 Q7TS71 Q8BQW1 Q8R4U7 Q99NG3 Q9CSL6 uc008vie.1 uc008vie.2 uc008vie.3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Note=Also detected in soma and dendrites of neurons. Predominantly expressed in the brain (at protein level). ventricular septum development molecular_function nucleus neural fold bending artery development uc008vie.1 uc008vie.2 uc008vie.3 
ENSMUST00000105851.9 Pithd1 ENSMUST00000105851.9 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 (from RefSeq NM_025411.4) ENSMUST00000105851.1 ENSMUST00000105851.2 ENSMUST00000105851.3 ENSMUST00000105851.4 ENSMUST00000105851.5 ENSMUST00000105851.6 ENSMUST00000105851.7 ENSMUST00000105851.8 NM_025411 PITH1_MOUSE Q8BMZ1 Q8BWR2 Trp26 uc012dnd.1 uc012dnd.2 uc012dnd.3 Promotes megakaryocyte differentiation by up-regulating RUNX1 expression (PubMed:25134913). Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BWR2-1; Sequence=Displayed; Name=2; IsoId=Q8BWR2-2; Sequence=VSP_024808; Belongs to the PITHD1 family. molecular_function nucleus uc012dnd.1 uc012dnd.2 uc012dnd.3 
ENSMUST00000105853.10 Srsf10 ENSMUST00000105853.10 serine and arginine-rich splicing factor 10, transcript variant 2 (from RefSeq NM_001080387.2) B1AV44 B1AV45 ENSMUST00000105853.1 ENSMUST00000105853.2 ENSMUST00000105853.3 ENSMUST00000105853.4 ENSMUST00000105853.5 ENSMUST00000105853.6 ENSMUST00000105853.7 ENSMUST00000105853.8 ENSMUST00000105853.9 Fusip1 NM_001080387 Nssr O70307 O88468 Q3TGW7 Q8CFZ1 Q9R0T9 Q9R0U0 SRS10_MOUSE Sfrs13a Srsf13a uc033ifn.1 uc033ifn.2 uc033ifn.3 Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A- containing regions, leading to inhibit exon skipping during alternative splicing (By similarity). May be involved in regulation of alternative splicing in neurons (PubMed:10583508). The phosphorylated but not the dephosphorylated form interacts with TRA2B/SFRS10. The dephosphorylated form interacts with SNRNP70. Interacts with FUS C-terminus. Interacts with YTHDC1, leading to inhibit RNA-binding activity of SRSF10. Nucleus speckle Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=TASR-1, NSSR1; IsoId=Q9R0U0-1; Sequence=Displayed; Name=2; IsoId=Q9R0U0-2; Sequence=VSP_010426; Name=3; Synonyms=TASR-2, NSSR2; IsoId=Q9R0U0-3; Sequence=VSP_010427, VSP_010428; Widely expressed, with high levels in brain and testis. Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock. Belongs to the splicing factor SR family. RNA splicing, via transesterification reactions regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated mRNA splice site selection mRNA processing RNA splicing cytosolic transport nuclear speck regulation of RNA splicing mRNA cis splicing, via spliceosome regulation of mRNA splicing, via spliceosome negative regulation of mRNA splicing, via spliceosome unfolded protein binding uc033ifn.1 uc033ifn.2 uc033ifn.3 
ENSMUST00000105854.2 Myom3 ENSMUST00000105854.2 myomesin family, member 3 (from RefSeq NM_001085509.2) A2ABU4 ENSMUST00000105854.1 MYOM3_MOUSE NM_001085509 uc008vgy.1 uc008vgy.2 uc008vgy.3 uc008vgy.4 May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. Homodimer. Cytoplasm, myofibril, sarcomere, M line Mainly expressed in slow muscle, extraocular muscle and embryonic/neonatal skeletal muscle (at protein level). Expression in skeletal muscle is fiber type specific, with the highest levels in type IIA fibers (intermediate speed) and lower levels in type I fibers. cytoplasm striated muscle thin filament muscle contraction structural constituent of muscle sarcomere Z disc skeletal muscle thin filament assembly skeletal muscle myosin thick filament assembly M band protein homodimerization activity sarcomere organization cardiac muscle fiber development actin filament binding muscle alpha-actinin binding cardiac myofibril assembly cardiac muscle tissue morphogenesis striated muscle myosin thick filament assembly uc008vgy.1 uc008vgy.2 uc008vgy.3 uc008vgy.4 
ENSMUST00000105855.2 Grhl3 ENSMUST00000105855.2 grainyhead like transcription factor 3, transcript variant 2 (from RefSeq NM_001415832.1) A2ADI2 ENSMUST00000105855.1 GRHL3_MOUSE Get1 Grhl3 NM_001415832 Q5FWH3 Som Tfcp2l4 uc008vgr.1 uc008vgr.2 uc008vgr.3 Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. Essential for epidermal differentiation and barrier formation at the end of embryogenesis with TGM3 as critical direct target (PubMed:21081122, PubMed:20654612, PubMed:25347468). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events such as eyelid fusion and epidermal wound repair (PubMed:21081122). Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury (PubMed:25347468). Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (PubMed:14608380, PubMed:20654612). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL1, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122). Homodimer, also forms heterodimers with GRHL1 and GRHL2 (By similarity). Interacts with LMO4 (PubMed:16949565). Nucleus At 8.5 dpc, expression is confined to the non- neural ectoderm immediately adjacent to the neural plate, which was undergoing folding to form the neural tube. At later time points, more widespread expression is observed in the surface ectoderm, with a progressive increase until 15.5 dpc. Also expressed in other tissues lined by squamous epithelium, including the oral cavity, urogenital sinus and anal canal. Mutant pups display neural tube defects and don't survive to weaning. During embryogenesis, fail to form the epidermal barrier and exhibit defective neural tube closure and embryonic wound repair. The epidermis show a severe barrier function defect associated with impaired differentiation of the epidermis, including defects of the stratum corneum, extracellular lipid composition and cell adhesion in the granular layer. Embryos have thoracolumbosacral spina bifida and curled tail, and 2% have coincident exencephaly. Embryos are smaller than their control littermates, exhibit failed eyelid fusion, the penetrance of which is influenced by genetic background, and shorter intestine with blood in the lumen (PubMed:14608380, PubMed:16949565, PubMed:21081122). Embryos have oral bilateral epithelial adhesions because of the loss of periderm and a cleft palate in some cases (PubMed:24360809). LMO4:GRHL3 double knockout embryos show significantly more frequent exencephaly than that found in single knockouts. Similarly, open-eye phenotype was more penetrant in double knockout mice. Double mutants show an enhancement of the epidermal terminal differentiation defect (PubMed:16949565). GRHL genes (GRHL1, GRHL2 and GRHL3) show a paradoxal lack of redundancy despite their extensive sequence identity in the DNA-binding and protein dimerization domains and the fact that the core consensus DNA binding sites are identical. They have related but remarkably different functions during embryogenesis because of their differential spatiotemporal expression patterns during development. Belongs to the grh/CP2 family. Grainyhead subfamily. RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding establishment of planar polarity neural tube closure DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter pattern specification process ectoderm development central nervous system development epidermis development positive regulation of gene expression chromatin DNA binding regulation of actin cytoskeleton organization wound healing positive regulation of GTPase activity sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter eyelid development in camera-type eye establishment of skin barrier cochlea morphogenesis planar cell polarity pathway involved in neural tube closure uc008vgr.1 uc008vgr.2 uc008vgr.3 
ENSMUST00000105859.8 Ncmap ENSMUST00000105859.8 noncompact myelin associated protein, transcript variant 1 (from RefSeq NM_145555.2) ENSMUST00000105859.1 ENSMUST00000105859.2 ENSMUST00000105859.3 ENSMUST00000105859.4 ENSMUST00000105859.5 ENSMUST00000105859.6 ENSMUST00000105859.7 NCMAP_MOUSE NM_145555 Q99JS0 uc008vgk.1 uc008vgk.2 uc008vgk.3 uc008vgk.4 Plays a role in myelin formation. Cell membrane ; Single-pass type I membrane protein Note=Localized mainly in the Schmidt-Lanterman incisures and paranodes of noncompact peripheral nerve myelin. Found in the peripheral nervous system (PNS) Schwann cells (at protein level). Expressed in the PNS, primarily limited to Schwann cells. Expressed in sciatic nerve and placenta at 15.5 dpc. Up-regulated in Schwann cells by EGR2 during nerve development and after nerve injury. Glycosylated. plasma membrane integral component of plasma membrane membrane integral component of membrane structural constituent of myelin sheath regulation of myelination positive regulation of myelination peripheral nervous system myelin formation paranode region of axon Schmidt-Lanterman incisure uc008vgk.1 uc008vgk.2 uc008vgk.3 uc008vgk.4 
ENSMUST00000105866.3 Aunip ENSMUST00000105866.3 aurora kinase A and ninein interacting protein (from RefSeq NM_001081099.1) AUNIP_MOUSE Aunip B2RR86 E9Q6Z5 ENSMUST00000105866.1 ENSMUST00000105866.2 NM_001081099 uc008vfg.1 uc008vfg.2 uc008vfg.3 DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle. Interacts (via C-terminus) with AURKA (via C-terminus). Interacts (via N-terminus) with NIN; this interaction blocks NIN phosphorylation by both AURKA and GSK3B. Identified in a complex with NIN and AURKA. Interacts with RBBP8/CtIP. Nucleus Chromosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Note=Accumulates at sites of DNA damage by binding to DNA substrates that mimick structures generated at stalled replication forks. Localizes to the centrosome in interphase and to the spindle pole in metaphase. Belongs to the AUNIP family. double-strand break repair via homologous recombination spindle pole DNA binding damaged DNA binding nucleus chromosome cytoplasm centrosome microtubule organizing center cytoskeleton DNA repair cellular response to DNA damage stimulus spindle organization negative regulation of double-strand break repair via nonhomologous end joining uc008vfg.1 uc008vfg.2 uc008vfg.3 
ENSMUST00000105869.9 Pafah2 ENSMUST00000105869.9 platelet-activating factor acetylhydrolase 2, transcript variant 2 (from RefSeq NM_133880.3) E9QNW7 ENSMUST00000105869.1 ENSMUST00000105869.2 ENSMUST00000105869.3 ENSMUST00000105869.4 ENSMUST00000105869.5 ENSMUST00000105869.6 ENSMUST00000105869.7 ENSMUST00000105869.8 NM_133880 PAFA2_MOUSE Pafah2 Q8R0Y7 Q8VDG7 uc008vey.1 uc008vey.2 uc008vey.3 uc008vey.4 uc008vey.5 Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (By similarity). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2- ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity). Reaction=a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O- alkyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:17777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707; EC=3.1.1.47; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17778; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1- O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:40479, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:44811, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40480; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O- hexadecyl-2-acetyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2- acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3- phosphocholine; Xref=Rhea:RHEA:41396, ChEBI:CHEBI:44811, ChEBI:CHEBI:64496, ChEBI:CHEBI:77288, ChEBI:CHEBI:78419; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41397; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4- enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N- (acetyl)-sphing-4-enine; Xref=Rhea:RHEA:41408, ChEBI:CHEBI:15378, ChEBI:CHEBI:44811, ChEBI:CHEBI:46979, ChEBI:CHEBI:57756, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41409; Evidence=; Reaction=a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1- organyl-2-lyso-sn-glycero-3-phospholipid = 1-O-alkyl-sn-glycero-3- phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid; Xref=Rhea:RHEA:11048, ChEBI:CHEBI:685, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707, ChEBI:CHEBI:76590; EC=2.3.1.149; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11049; Evidence=; Reaction=1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+); Xref=Rhea:RHEA:41700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30921, ChEBI:CHEBI:64496, ChEBI:CHEBI:78371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41701; Evidence=; Reaction=1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate; Xref=Rhea:RHEA:41696, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30031, ChEBI:CHEBI:64496, ChEBI:CHEBI:78369; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41697; Evidence=; Reaction=1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+); Xref=Rhea:RHEA:41692, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:64496, ChEBI:CHEBI:78368; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41693; Evidence=; Reaction=1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate; Xref=Rhea:RHEA:41688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17272, ChEBI:CHEBI:64496, ChEBI:CHEBI:78367; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41689; Evidence=; Monomer. Cytoplasm Membrane ; Lipid-anchor Endoplasmic reticulum membrane ; Lipid-anchor Note=In resting cells, localizes to intracellular membranes and cytoplasm. Translocates from the cytoplasm to intracellular membranes upon oxidative stress. Belongs to the serine esterase family. 1-alkyl-2-acetylglycerophosphocholine esterase activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process membrane lipid catabolic process hydrolase activity negative regulation of apoptotic process uc008vey.1 uc008vey.2 uc008vey.3 uc008vey.4 uc008vey.5 
ENSMUST00000105874.9 Slc30a2 ENSMUST00000105874.9 solute carrier family 30 (zinc transporter), member 2, transcript variant 1 (from RefSeq NM_001039677.2) D3Z5N0 ENSMUST00000105874.1 ENSMUST00000105874.2 ENSMUST00000105874.3 ENSMUST00000105874.4 ENSMUST00000105874.5 ENSMUST00000105874.6 ENSMUST00000105874.7 ENSMUST00000105874.8 NM_001039677 Q2HJ10 Slc30a2 ZNT2_MOUSE Znt2 uc008veu.1 uc008veu.2 uc008veu.3 uc008veu.4 [Isoform 1]: Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity (PubMed:21289295). Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (Probable). By concentrating zinc ions into lysosomes participates to lysosomal- mediated cell death during early mammary gland involution (By similarity). [Isoform 2]: Electroneutral proton-coupled antiporter mediating the efflux of zinc ions through the plasma membrane. Reaction=2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out); Xref=Rhea:RHEA:72627, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105; Evidence=; Homodimer. Interacts (via lysosomal targeting motif) with AP3D1; in AP-3-mediated transport to lysosomes. Interacts with TMEM163. Q2HJ10; Q3UVU3: Slc30a10; NbExp=2; IntAct=EBI-13945312, EBI-13945374; [Isoform 1]: Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein Zymogen granule membrane ; Multi-pass membrane protein Endosome membrane ; Multi- pass membrane protein Lysosome membrane ; Multi-pass membrane protein Mitochondrion inner membrane ; Multi-pass membrane protein Note=Localization to lysosomes is induced by TNF-alpha. [Isoform 2]: Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long isoform ; IsoId=Q2HJ10-1; Sequence=Displayed; Name=2; Synonyms=Short isoform ; IsoId=Q2HJ10-2; Sequence=VSP_061730; Down-regulated upon zinc starvation (at protein level). Up- regulated upon zinc intake (PubMed:20133611). Up-regulated by dexamethasone (PubMed:20133611). Phosphorylated at Ser-295. Phosphorylation at Ser-295 prevents localization to lysosomes. Dephosphorylation of Ser-295 which triggers localization to lysosomes, accumulation of zinc into lysosomes and lysosomal-mediated cell death is induced by TNF-alpha. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. zinc ion transmembrane transporter activity protein binding cytoplasm late endosome vacuole vacuolar membrane plasma membrane ion transport cation transport zinc II ion transport cation transmembrane transporter activity response to zinc ion membrane integral component of membrane cytoplasmic vesicle intracellular membrane-bounded organelle transmembrane transport regulation of sequestering of zinc ion positive regulation of sequestering of zinc ion zinc II ion transmembrane transport uc008veu.1 uc008veu.2 uc008veu.3 uc008veu.4 
ENSMUST00000105875.8 Trim63 ENSMUST00000105875.8 tripartite motif-containing 63, transcript variant 2 (from RefSeq NM_001369245.1) ENSMUST00000105875.1 ENSMUST00000105875.2 ENSMUST00000105875.3 ENSMUST00000105875.4 ENSMUST00000105875.5 ENSMUST00000105875.6 ENSMUST00000105875.7 F8VPZ1 F8VPZ1_MOUSE NM_001369245 Trim63 uc008vet.1 uc008vet.2 ubiquitin-protein transferase activity cytoplasm muscle contraction zinc ion binding negative regulation of cardiac muscle hypertrophy skeletal muscle atrophy response to electrical stimulus involved in regulation of muscle adaptation protein ubiquitination titin binding contractile fiber metal ion binding response to glucocorticoid response to interleukin-1 uc008vet.1 uc008vet.2 
ENSMUST00000105884.2 Zfp683 ENSMUST00000105884.2 Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:22885984, PubMed:27102484). Plays a role in the development, retention and long- term establishment of adaptive and innate tissue-resident lymphocyte T- cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:22885984, PubMed:27102484). Also plays a role in the differentiation of both thymic and peripheral NKT cells (PubMed:22885984). Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation (PubMed:22885984). Positively regulates granzyme B production in NKT cells after innate stimulation (PubMed:22885984). Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions (PubMed:27102484). (from UniProt I7HJS4) ENSMUST00000105884.1 Gm13060 I7HJS4 ZN683_MOUSE Znf683 uc290qqx.1 uc290qqx.2 Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:22885984, PubMed:27102484). Plays a role in the development, retention and long- term establishment of adaptive and innate tissue-resident lymphocyte T- cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:22885984, PubMed:27102484). Also plays a role in the differentiation of both thymic and peripheral NKT cells (PubMed:22885984). Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation (PubMed:22885984). Positively regulates granzyme B production in NKT cells after innate stimulation (PubMed:22885984). Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions (PubMed:27102484). Nucleus Expressed in tissue-resident memory T (Trm) cell population in non-lymphoid organs, such as skin and gut (PubMed:27102484). Expressed in innate lymphocytes, including tissue- resident natural killer (trNK) and natural killer T (NKT) cells in thymus, spleen and liver (PubMed:22885984, PubMed:27102484). Up-regulated by interleukin IL15 in a TBX21/T-bet-dependent manner in tissue-resident memory T (Trm) cell population (PubMed:27102484). Up-regulated during the differentiation of natural killer T (NKT) cells (PubMed:22885984). Down-regulated in NKT cells after antigenic stimulation (PubMed:22885984). (Microbial infection) Up-regulated in response to Herpes simplex virus (HSV) infection in skin CD8(+) tissue-resident memory T (Trm) cells, but not in spleen. (Microbial infection) Up-regulated in response to choriomeningitis virus (LCMV) infection in gut CD8(+) tissue-resident memory T (Trm) cells. Mice show a reduction in tissue-resident memory T (Trm) cell population maintenance in the skin, gut, liver and kidney but not of splenic T-cells (PubMed:22885984, PubMed:27102484). Double knockouts for Znf683 and Prdm1/Blimp1 result in a stronger inhibition of Trm cell population maintenance (PubMed:27102484). Display an enhancement of natural killer T (NKT) cells migration preferentially to the white pulp of the spleen in response to chemotactic stimuli (PubMed:27102484). Also results in the derepressed expression of a large number of genes implicated in the egress of tissue-resident T- cells from non-lymphoide organs (PubMed:27102484). Belongs to the krueppel C2H2-type zinc-finger protein family. natural killer cell differentiation adaptive immune response immune system process nucleic acid binding DNA binding cellular_component nucleus regulation of gene expression regulation of natural killer cell differentiation regulation of natural killer cell differentiation involved in immune response regulation of extrathymic T cell differentiation innate immune response metal ion binding regulation of NK T cell differentiation promoter-specific chromatin binding uc290qqx.1 uc290qqx.2 
ENSMUST00000105894.11 Rps6ka1 ENSMUST00000105894.11 ribosomal protein S6 kinase polypeptide 1, transcript variant 1 (from RefSeq NM_009097.5) ENSMUST00000105894.1 ENSMUST00000105894.10 ENSMUST00000105894.2 ENSMUST00000105894.3 ENSMUST00000105894.4 ENSMUST00000105894.5 ENSMUST00000105894.6 ENSMUST00000105894.7 ENSMUST00000105894.8 ENSMUST00000105894.9 NM_009097 Q505N6 Q505N6_MOUSE Rps6ka1 uc008vdn.1 uc008vdn.2 uc008vdn.3 uc008vdn.4 uc008vdn.5 uc008vdn.6 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity ATP binding nucleus cytosol protein phosphorylation apoptotic process kinase activity phosphorylation transferase activity intracellular signal transduction cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of transcription from RNA polymerase II promoter positive regulation of hepatic stellate cell activation uc008vdn.1 uc008vdn.2 uc008vdn.3 uc008vdn.4 uc008vdn.5 uc008vdn.6 
ENSMUST00000105897.10 Arid1a ENSMUST00000105897.10 AT-rich interaction domain 1A, transcript variant 1 (from RefSeq NM_001080819.2) A2BH40 ARI1A_MOUSE Baf250 Baf250a ENSMUST00000105897.1 ENSMUST00000105897.2 ENSMUST00000105897.3 ENSMUST00000105897.4 ENSMUST00000105897.5 ENSMUST00000105897.6 ENSMUST00000105897.7 ENSMUST00000105897.8 ENSMUST00000105897.9 NM_001080819 Osa1 Q640Q1 Q925Q1 Smarcf1 uc008vdh.1 uc008vdh.2 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self- renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Component of SWI/SNF chromatin remodeling complexes, in some of which it can be mutually exclusive with ARID1B/BAF250B. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the BAF (SWI/SNF-A) complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (PubMed:17640523). Component of a SWI/SNF-like EBAFa complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCC1/BAF155, SMARCC2/BAF170, BAF250A and MLLT1/ENL. Interacts through its C-terminus with SMARCA2/BRM/BAF190B and SMARCA4/BRG1/BAF190A. Interacts with SMARCC1/BAF155 (By similarity). Interacts with FOS (via bZIP domain and leucine-zipper region), FOSB isoform 1 and 2, FOSL1 and FOSL2 (PubMed:29272704). A2BH40; O35845: Smarca4; NbExp=2; IntAct=EBI-371499, EBI-371515; A2BH40; Q3TKT4: Smarca4; NbExp=7; IntAct=EBI-371499, EBI-1210244; Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=A2BH40-1; Sequence=Displayed; Name=2; IsoId=A2BH40-2; Sequence=VSP_038737, VSP_038739; Name=3; IsoId=A2BH40-3; Sequence=VSP_038740; Name=4; IsoId=A2BH40-4; Sequence=VSP_038737, VSP_038738, VSP_038739; Widely expressed. Expressed at high levels in the testis. Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at 10.5 dpc-16.5 dpc. In the earlier stages at 9.5 dpc and 10.5 dpc, is fairly ubiquitous though with clearly elevated expression in the progress zone and lateral mesoderm of limb buds, optic and otic vesicle, neural tube, and brain. Later on at 11.5 dpc and 12.5 dpc, expression becomes more restricted and is confined to the interdigital area of limbs, dorsal mes/metencephalon, neocortex, and neural tube. Expression is seen in the eye lens from 10.5 dpc until 12.5 dpc. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin formation of primary germ layer neural tube closure cardiac chamber development optic cup formation involved in camera-type eye development DNA binding protein binding nucleus nucleoplasm chromatin organization nucleosome disassembly chromatin remodeling maintenance of chromatin silencing gastrulation nervous system development embryo implantation SWI/SNF complex ligand-dependent nuclear receptor binding stem cell population maintenance intracellular estrogen receptor signaling pathway androgen receptor signaling pathway forebrain development brahma complex glucocorticoid receptor signaling pathway ATP-dependent chromatin remodeling positive regulation of transcription, DNA-templated cardiac muscle cell differentiation placenta blood vessel development npBAF complex nBAF complex toxin transport nucleosome binding uc008vdh.1 uc008vdh.2 
ENSMUST00000105898.2 Fgf3 ENSMUST00000105898.2 fibroblast growth factor 3 (from RefSeq NM_008007.2) ENSMUST00000105898.1 Fgf3 Fgf5c NM_008007 Q0VG15 Q0VG15_MOUSE uc009kqp.1 uc009kqp.2 uc009kqp.3 uc009kqp.4 Belongs to the heparin-binding growth factors family. fibroblast growth factor receptor binding extracellular region growth factor activity positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway negative regulation of cardiac muscle tissue development uc009kqp.1 uc009kqp.2 uc009kqp.3 uc009kqp.4 
ENSMUST00000105902.8 Shank2 ENSMUST00000105902.8 Cytoplasm Postsynaptic density (from UniProt D3Z5K8) AB099695 D3Z5K8 D3Z5K8_MOUSE ENSMUST00000105902.1 ENSMUST00000105902.2 ENSMUST00000105902.3 ENSMUST00000105902.4 ENSMUST00000105902.5 ENSMUST00000105902.6 ENSMUST00000105902.7 Shank2 uc291xph.1 uc291xph.2 Cytoplasm Postsynaptic density Belongs to the SHANK family. uc291xph.1 uc291xph.2 
ENSMUST00000105907.9 Tmem222 ENSMUST00000105907.9 transmembrane protein 222, transcript variant 2 (from RefSeq NR_110978.1) A2AE96 D4Ertd196e ENSMUST00000105907.1 ENSMUST00000105907.2 ENSMUST00000105907.3 ENSMUST00000105907.4 ENSMUST00000105907.5 ENSMUST00000105907.6 ENSMUST00000105907.7 ENSMUST00000105907.8 NR_110978 Q8BVA2 Q8CI41 Q9CYN3 TM222_MOUSE uc008vcp.1 uc008vcp.2 uc008vcp.3 Membrane ; Multi-pass membrane protein Cell projection, dendrite Sequence=BAB30776.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008vcp.1 uc008vcp.2 uc008vcp.3 
ENSMUST00000105910.2 Cd164l2 ENSMUST00000105910.2 CD164 sialomucin-like 2 (from RefSeq NM_027152.1) B1AUM9 C16L2_MOUSE ENSMUST00000105910.1 NM_027152 Q9D6W7 uc008vcj.1 uc008vcj.2 uc008vcj.3 Membrane ; Single-pass type I membrane protein Belongs to the CD164 family. molecular_function biological_process membrane integral component of membrane cytoplasmic vesicle uc008vcj.1 uc008vcj.2 uc008vcj.3 
ENSMUST00000105911.2 Gpr3 ENSMUST00000105911.2 Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways (PubMed:15956199, PubMed:19259266). Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand (PubMed:26455425, PubMed:34048700). Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons. Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (PubMed:34871769). (from UniProt P35413) BC138248 ENSMUST00000105911.1 GPR3_MOUSE Gpcr3 P35413 Q3USD4 uc029uzs.1 uc029uzs.2 uc029uzs.3 uc029uzs.4 Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways (PubMed:15956199, PubMed:19259266). Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand (PubMed:26455425, PubMed:34048700). Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons. Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (PubMed:34871769). Cell membrane; Multi-pass membrane protein Expressed in both the forebrain and hindbrain, with the highest level in habenula (PubMed:8262253). Lower level expression in the testis. Expressed in several metabolically active peripheral tissues, although at lower levels than in the central nervous system (CNS) (PubMed:26455425). Mice are fertile but display progressive reduction in litter size despite a stable age-independent alteration of the meiotic pause, characterized by premature resumption of meiosis in about one-third of antral follicles in mutant females regardless of age. Aging mutant mice had severe reduction of fertility, manifested by an increasing number of nondeveloping early embryos upon spontaneous ovulation and massive amounts of fragmented oocytes after superovulation (PubMed:15956199). Older mice have also reduced total energy expenditure, Hippocampal neurons show delayed polarity formation with an increased DPYSL2 phosphorylation at the neurite tips (PubMed:34871769). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane regulation of meiotic nuclear division positive regulation of cAMP-mediated signaling regulation of cytosolic calcium ion concentration uc029uzs.1 uc029uzs.2 uc029uzs.3 uc029uzs.4 
ENSMUST00000105916.8 Ahdc1 ENSMUST00000105916.8 AT hook, DNA binding motif, containing 1, transcript variant 1 (from RefSeq NM_146155.3) AHDC1_MOUSE Ahdc1 ENSMUST00000105916.1 ENSMUST00000105916.2 ENSMUST00000105916.3 ENSMUST00000105916.4 ENSMUST00000105916.5 ENSMUST00000105916.6 ENSMUST00000105916.7 NM_146155 Q5U5N7 Q6PAL7 Q8C4Y6 Q8VCU7 uc008vcd.1 uc008vcd.2 Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (By similarity). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (By similarity). Nucleus Chromosome Note=Associates with promoter and enhancer regions. Lethality; mice do not survive past birth (PubMed:35585237). Mutant mice show developmental patterning defects affecting craniofacial structure, abdominal wall closure and epidermal stratification (PubMed:35585237). Sequence=AAH19130.1; Type=Erroneous initiation; Evidence=; molecular_function DNA binding cellular_component biological_process uc008vcd.1 uc008vcd.2 
ENSMUST00000105935.8 Igf2 ENSMUST00000105935.8 insulin-like growth factor 2, transcript variant 4 (from RefSeq NM_001315488.1) E9QLW5 ENSMUST00000105935.1 ENSMUST00000105935.2 ENSMUST00000105935.3 ENSMUST00000105935.4 ENSMUST00000105935.5 ENSMUST00000105935.6 ENSMUST00000105935.7 IGF2_MOUSE Igf-2 NM_001315488 P09535 uc057cbk.1 uc057cbk.2 uc057cbk.3 This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this gene in mice results in prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities. Mice lacking the encoded protein exhibit growth deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]. The insulin-like growth factors possess growth-promoting activity (PubMed:29440408). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable) (PubMed:2330056, PubMed:12087403). IGF2 is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (By similarity). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (PubMed:16901893). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (PubMed:32557799). Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. Interacts with MYORG; this interaction is required for IGF2 secretion (PubMed:19706595). Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4; integrin-binding is required for IGF2 signaling (By similarity). Secreted Event=Alternative promoter usage; Named isoforms=2; Name=1; IsoId=P09535-1; Sequence=Displayed; Name=2; IsoId=P09535-2; Sequence=VSP_059113; Expressed in the heart, blood serum, kidney and skeletal muscle including the tibialis anterior muscle. At 8 dpc, 9.5 dpc and 16.5 dpc, transcripts from parental allele are detected in embryonic and extraembryonic tissues (PubMed:28522536, PubMed:1997210). At 16.5 dpc, transcripts from parental and maternal alleles are detected only in the choroid plexus and the leptomeninges (PubMed:1997210). Expressed in fetal muscle and brain tissue at 12.5 dpc (PubMed:29440408). Low levels of expression during myoblast proliferation. Levels rise rapidly during myoblast differentiation and then decrease. [Isoform 2]: Predominant isoform expressed in fetal muscle tissues at 12.5 dpc. Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2. Heterozygous animals are smaller than their wild type littermates but appear normal, reach sexual maturity and are fertile (PubMed:2330056). Transmission of this mutation through the male germline results in heterozygous progeny that are growth deficient. In contrast, when the disrupted gene is transmitted maternally, the heterozygous offspring are phenotypically normal. Homozygous mutants are indistinguishable in appearance from growth- deficient heterozygous siblings (PubMed:1997210). Mutant animals for transcript P0 specifically show a reduced growth of the placenta followed by fetal growth restriction, passive permeability for nutrients of the placenta is decreased (PubMed:12087403). The IGF2 locus is imprinted. Paternal inherited gene is expressed, while the maternal inherited gene is imprinted, hence silenced (PubMed:1997210). It is differentially regulated in the placenta and fetus, transcribed from 3 promoters P1, P2 and P3 in both fetus and placenta and additionally from a fourth placental-specific promoter, P0 (Probable). [Isoform 1]: Product of 4 different transcripts regulated by 4 different promoters, denominated P0, P1, P2 and P3. Belongs to the insulin family. negative regulation of transcription from RNA polymerase II promoter ossification osteoblast differentiation in utero embryonic development embryonic placenta development positive regulation of protein phosphorylation insulin receptor binding insulin-like growth factor receptor binding integrin binding hormone activity protein binding extracellular region extracellular space carbohydrate metabolic process glucose metabolic process memory growth factor activity positive regulation of cell proliferation animal organ morphogenesis response to organic cyclic compound exocrine pancreas development regulation of histone modification response to nicotine insulin receptor signaling pathway via phosphatidylinositol 3-kinase positive regulation of multicellular organism growth positive regulation of activated T cell proliferation response to drug positive regulation of catalytic activity positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration protein serine/threonine kinase activator activity positive regulation of glycogen biosynthetic process positive regulation of angiogenesis positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter negative regulation of natural killer cell mediated cytotoxicity positive regulation of insulin receptor signaling pathway receptor agonist activity positive regulation of peptidyl-tyrosine phosphorylation striated muscle cell differentiation regulation of muscle cell differentiation positive regulation of cell division positive regulation of protein kinase B signaling embryonic placenta morphogenesis positive regulation of protein serine/threonine kinase activity positive regulation of steroid hormone biosynthetic process positive regulation of vascular endothelial cell proliferation positive regulation of glycogen (starch) synthase activity uc057cbk.1 uc057cbk.2 uc057cbk.3 
ENSMUST00000105943.8 Tnnt3 ENSMUST00000105943.8 troponin T3, skeletal, fast, transcript variant 15 (from RefSeq NM_001347552.1) A2A6I5 A2A6I5_MOUSE ENSMUST00000105943.1 ENSMUST00000105943.2 ENSMUST00000105943.3 ENSMUST00000105943.4 ENSMUST00000105943.5 ENSMUST00000105943.6 ENSMUST00000105943.7 NM_001347552 Tnnt3 uc009knx.1 uc009knx.2 uc009knx.3 uc009knx.4 Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Belongs to the troponin T family. troponin complex regulation of muscle contraction regulation of striated muscle contraction uc009knx.1 uc009knx.2 uc009knx.3 uc009knx.4 
ENSMUST00000105951.8 Rcc1 ENSMUST00000105951.8 Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. (from UniProt Q8VE37) BC019807 Chc1 ENSMUST00000105951.1 ENSMUST00000105951.2 ENSMUST00000105951.3 ENSMUST00000105951.4 ENSMUST00000105951.5 ENSMUST00000105951.6 ENSMUST00000105951.7 Q3UDB6 Q8VE37 RCC1_MOUSE uc290qla.1 uc290qla.2 Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. Interacts with RAN. Interacts with KPNA3. Interacts (via N- terminus and RCC1 repeats) with KPNA4. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. Nucleus Chromosome Cytoplasm Note=Predominantly nuclear in interphase cells. Binds to mitotic chromosomes. N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Dimethylation produces a permanent positive charge on the amino group, which facilitates electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomes during nucleotide exchange on Ran. G1/S transition of mitotic cell cycle chromatin nuclear chromatin condensed nuclear chromosome DNA binding chromatin binding guanyl-nucleotide exchange factor activity Ran guanyl-nucleotide exchange factor activity nucleus nucleoplasm chromosome cytoplasm cell cycle mitotic spindle organization chromosome segregation regulation of mitotic nuclear division Ran GTPase binding nucleosome binding nucleosomal DNA binding nuclear membrane macromolecular complex histone binding sulfate binding protein heterodimerization activity spindle assembly protein heterotetramerization cell division uc290qla.1 uc290qla.2 
ENSMUST00000105965.8 Gmeb1 ENSMUST00000105965.8 glucocorticoid modulatory element binding protein 1, transcript variant 2 (from RefSeq NM_001122992.1) ENSMUST00000105965.1 ENSMUST00000105965.2 ENSMUST00000105965.3 ENSMUST00000105965.4 ENSMUST00000105965.5 ENSMUST00000105965.6 ENSMUST00000105965.7 GMEB1_MOUSE NM_001122992 Q80Y88 Q9JL60 uc008vau.1 uc008vau.2 uc008vau.3 uc008vau.4 Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity). Homodimer, and heterodimer of GMEB1 and GMEB2. Interacts with TRIM63 (By similarity). Interacts with the glucocorticoid receptor (NR3C1) and NCOA2/TIF2. May interact with HSP27 and CREB-binding protein (CBP). Nucleus. Cytoplasm. Note=May be also cytoplasmic. Ubiquitous. Low levels were detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus nucleoplasm cytoplasm regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter metal ion binding uc008vau.1 uc008vau.2 uc008vau.3 uc008vau.4 
ENSMUST00000105971.8 Tnni2 ENSMUST00000105971.8 troponin I, skeletal, fast 2 (from RefSeq NM_009405.3) A2A6J9 ENSMUST00000105971.1 ENSMUST00000105971.2 ENSMUST00000105971.3 ENSMUST00000105971.4 ENSMUST00000105971.5 ENSMUST00000105971.6 ENSMUST00000105971.7 NM_009405 P13412 TNNI2_MOUSE uc033jdk.1 uc033jdk.2 uc033jdk.3 Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Belongs to the troponin I family. skeletal muscle contraction actin binding nucleus troponin complex muscle contraction regulation of muscle contraction troponin T binding positive regulation of transcription, DNA-templated metal ion binding cardiac muscle contraction uc033jdk.1 uc033jdk.2 uc033jdk.3 
ENSMUST00000105976.8 Syt8 ENSMUST00000105976.8 synaptotagmin VIII, transcript variant 2 (from RefSeq NM_001285857.1) ENSMUST00000105976.1 ENSMUST00000105976.2 ENSMUST00000105976.3 ENSMUST00000105976.4 ENSMUST00000105976.5 ENSMUST00000105976.6 ENSMUST00000105976.7 F2Z3W8 F2Z3W8_MOUSE NM_001285857 Syt8 uc009kmz.1 uc009kmz.2 uc009kmz.3 uc009kmz.4 Belongs to the synaptotagmin family. exocytosis membrane integral component of membrane uc009kmz.1 uc009kmz.2 uc009kmz.3 uc009kmz.4 
ENSMUST00000105993.4 Nkain1 ENSMUST00000105993.4 Na+/K+ transporting ATPase interacting 1, transcript variant 1 (from RefSeq NM_025998.5) A6MHP4 ENSMUST00000105993.1 ENSMUST00000105993.2 ENSMUST00000105993.3 Fam77c NKAI1_MOUSE NM_025998 Q9D035 Q9D0Q6 uc008uzj.1 uc008uzj.2 uc008uzj.3 uc008uzj.4 Interacts with ATP1B1 C-terminus. Cell membrane ; Multi-pass membrane protein Detected in the brain only and specifically in neurons. Expressed in multiple regions such as cerebral cortex, thalamus, hippocampus, olfactory bulb and brainstem as well as in cerebellum with high expression in granular cell layer. Belongs to the NKAIN family. regulation of sodium ion transport plasma membrane membrane integral component of membrane ATPase binding uc008uzj.1 uc008uzj.2 uc008uzj.3 uc008uzj.4 
ENSMUST00000105994.4 Snrnp40 ENSMUST00000105994.4 small nuclear ribonucleoprotein 40 (U5) (from RefSeq NM_025645.2) ENSMUST00000105994.1 ENSMUST00000105994.2 ENSMUST00000105994.3 NM_025645 Q3TEJ3 Q6PE01 Q9DCX3 SNR40_MOUSE Wdr57 uc008uzf.1 uc008uzf.2 uc008uzf.3 uc008uzf.4 Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex. Part of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6- U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Component of the minor spliceosome, which splices U12-type introns (By similarity). Nucleus Sequence=BAB22049.1; Type=Frameshift; Evidence=; nucleus spliceosomal complex cytosol mRNA processing RNA splicing nuclear speck U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome uc008uzf.1 uc008uzf.2 uc008uzf.3 uc008uzf.4 
ENSMUST00000105996.8 Serinc2 ENSMUST00000105996.8 serine incorporator 2, transcript variant 1 (from RefSeq NM_172702.3) ENSMUST00000105996.1 ENSMUST00000105996.2 ENSMUST00000105996.3 ENSMUST00000105996.4 ENSMUST00000105996.5 ENSMUST00000105996.6 ENSMUST00000105996.7 NM_172702 Q8K0E7 SERC2_MOUSE Tde2l uc008uzc.1 uc008uzc.2 uc008uzc.3 Membrane ; Multi-pass membrane protein Belongs to the TDE1 family. phosphatidylserine metabolic process sphingolipid metabolic process membrane integral component of membrane positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity positive regulation of serine C-palmitoyltransferase activity uc008uzc.1 uc008uzc.2 uc008uzc.3 
ENSMUST00000105998.8 Tinagl1 ENSMUST00000105998.8 tubulointerstitial nephritis antigen-like 1, transcript variant 1 (from RefSeq NM_023476.3) Arg1 ENSMUST00000105998.1 ENSMUST00000105998.2 ENSMUST00000105998.3 ENSMUST00000105998.4 ENSMUST00000105998.5 ENSMUST00000105998.6 ENSMUST00000105998.7 Lcn7 NM_023476 Q99JR5 Q9EQT9 TINAL_MOUSE Tinagl uc008uza.1 uc008uza.2 uc008uza.3 uc008uza.4 May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein. Secreted. Highly expressed in kidney, heart and adrenocortical cells of adrenal glands. Moderately expressed in spleen and liver. Also found in prostate, seminal vesicle, epididymis and testis in male reproductive organs. In adrenal glands is found in the outer cortical regions corresponding to the zona glomerulosa (zG) and the undifferentiated cell zone (zU) (at protein level). Down-regulated in prostate after castration. Glycosylated. Belongs to the peptidase C1 family. Sequence=BAB20596.1; Type=Frameshift; Evidence=; scavenger receptor activity extracellular matrix structural constituent extracellular region extracellular space cytoplasm proteolysis endocytosis immune response cell adhesion cysteine-type peptidase activity polysaccharide binding laminin binding uc008uza.1 uc008uza.2 uc008uza.3 uc008uza.4 
ENSMUST00000106000.10 Cd151 ENSMUST00000106000.10 CD151 antigen, transcript variant 1 (from RefSeq NM_009842.3) CD151_MOUSE ENSMUST00000106000.1 ENSMUST00000106000.2 ENSMUST00000106000.3 ENSMUST00000106000.4 ENSMUST00000106000.5 ENSMUST00000106000.6 ENSMUST00000106000.7 ENSMUST00000106000.8 ENSMUST00000106000.9 NM_009842 O35566 O89118 Peta3 uc012fxg.1 uc012fxg.2 uc012fxg.3 Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. Interacts with integrins ITGA3:ITGB1, ITGA5:ITGB1, ITGA3:ITGB1 and ITGA6:ITGB4 and with CD9 and CD181. Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3. O35566; Q62470: Itga3; NbExp=2; IntAct=EBI-8369654, EBI-8398907; Membrane; Multi-pass membrane protein. Palmitoylated. Palmitoylation by ZDHHC2 regulates CD151 expression, association with other tetraspanin family proteins and function in cell adhesion. Belongs to the tetraspanin (TM4SF) family. integrin binding protein binding basement membrane integral component of plasma membrane cell surface membrane integral component of membrane cell migration positive regulation of cell migration T cell proliferation wound healing, spreading of cells positive regulation of endocytosis uc012fxg.1 uc012fxg.2 uc012fxg.3 
ENSMUST00000106008.3 Gatd1 ENSMUST00000106008.3 glutamine amidotransferase like class 1 domain containing 1 (from RefSeq NM_172116.4) ENSMUST00000106008.1 ENSMUST00000106008.2 GALD1_MOUSE Gatd1 NM_172116 Pddc1 Q8BFQ8 Q8C2Q9 uc012fwy.1 uc012fwy.2 uc012fwy.3 Secreted Belongs to the peptidase C56 family. Sequence=BAC40181.1; Type=Frameshift; Evidence=; extracellular region uc012fwy.1 uc012fwy.2 uc012fwy.3 
ENSMUST00000106015.9 Adgrb2 ENSMUST00000106015.9 adhesion G protein-coupled receptor B2, transcript variant 3 (from RefSeq NM_001290715.2) AGRB2_MOUSE B1ASB7 B1ASB8 B2FDE3 Bai2 ENSMUST00000106015.1 ENSMUST00000106015.2 ENSMUST00000106015.3 ENSMUST00000106015.4 ENSMUST00000106015.5 ENSMUST00000106015.6 ENSMUST00000106015.7 ENSMUST00000106015.8 NM_001290715 Q3TYC8 Q3UN11 Q3UNE2 Q6PGN0 Q8CGM1 uc008uyp.1 uc008uyp.2 uc008uyp.3 Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (PubMed:12218411). Receptor activity is regulated by proteolytic processing. The long N-terminal has a an inhibitory effect on the constitutive signaling activity. Removal of the N-terminal region induces an increase of the receptor activity. Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C- terminal fragment predominantly remain associated and non-covalently linked. Interacts with GABPB2 (PubMed:16412436). Interacts (via carboxy-terminus) with TAX1BP3. Interacts with GNAZ (By similarity). Interacts with SH3GL2 (PubMed:28891236). Q8CGM1; Q06547: GABPB1; Xeno; NbExp=3; IntAct=EBI-8014984, EBI-618165; Cell membrane ; Multi-pass membrane protein Secreted Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CGM1-1; Sequence=Displayed; Name=2; IsoId=Q8CGM1-2; Sequence=VSP_019762; Name=3; IsoId=Q8CGM1-3; Sequence=VSP_019763; Specifically expressed in the brain. The peak level in the brain is observed 10 days after birth. Ubiquitous in embryonic tissues, but expression is acutely down-regulated after birth, except in the brain, to a level that is maintained throughout adulthood. Down-regulated after hypoxia. Glycosylated. Autoproteolytically processed at the GPS domain; this cleavage modulates receptor activity. Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment. Deficient mice show significant resistance to depression after repeated stress in the social defeat test. Additionally, hippocampal cell proliferation in deficient mice is increased. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. transmembrane signaling receptor activity G-protein coupled receptor activity protein binding centrosome plasma membrane integral component of plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway peripheral nervous system development membrane integral component of membrane negative regulation of angiogenesis calcineurin-NFAT signaling cascade positive regulation of synapse assembly uc008uyp.1 uc008uyp.2 uc008uyp.3 
ENSMUST00000106027.9 Phrf1 ENSMUST00000106027.9 PHD and ring finger domains 1, transcript variant 7 (from RefSeq NR_185020.1) A6H619 ENSMUST00000106027.1 ENSMUST00000106027.2 ENSMUST00000106027.3 ENSMUST00000106027.4 ENSMUST00000106027.5 ENSMUST00000106027.6 ENSMUST00000106027.7 ENSMUST00000106027.8 Kiaa1542 NR_185020 PHRF1_MOUSE Phrf1 Q505G1 Q6ZPN4 uc009kkb.1 uc009kkb.2 uc009kkb.3 Interacts with POLR2A (via the C-terminal domain). Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=A6H619-1; Sequence=Displayed; Name=2 ; IsoId=A6H619-2; Sequence=VSP_052978, VSP_052979; Sequence=BAC98197.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence=; transcription from RNA polymerase II promoter mRNA processing protein domain specific binding metal ion binding RNA polymerase binding uc009kkb.1 uc009kkb.2 uc009kkb.3 
ENSMUST00000106041.3 Depdc1a ENSMUST00000106041.3 DEP domain containing 1a, transcript variant 3 (from RefSeq NM_001172093.1) DEP1A_MOUSE ENSMUST00000106041.1 ENSMUST00000106041.2 NM_001172093 Q8BHF1 Q8CIG0 Q99JN3 uc008rwa.1 uc008rwa.2 uc008rwa.3 uc008rwa.4 May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells (By similarity). Can form dimers. Interacts with ZNF224 (By similarity). Nucleus Note=Colocalizes with ZNF224 at the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CIG0-1; Sequence=Displayed; Name=2; IsoId=Q8CIG0-2; Sequence=VSP_024656, VSP_024657, VSP_024658; Sequence=AAH05799.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; GTPase activator activity nucleus signal transduction transcriptional repressor complex intracellular signal transduction positive regulation of GTPase activity negative regulation of transcription, DNA-templated uc008rwa.1 uc008rwa.2 uc008rwa.3 uc008rwa.4 
ENSMUST00000106042.9 Ifitm1 ENSMUST00000106042.9 interferon induced transmembrane protein 1, transcript variant 1 (from RefSeq NM_026820.3) ENSMUST00000106042.1 ENSMUST00000106042.2 ENSMUST00000106042.3 ENSMUST00000106042.4 ENSMUST00000106042.5 ENSMUST00000106042.6 ENSMUST00000106042.7 ENSMUST00000106042.8 IFM1_MOUSE Ifitm1 NM_026820 Q8R2S7 Q9D103 uc009kja.1 uc009kja.2 uc009kja.3 uc009kja.4 IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN- gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. Interacts with CD81. Part of a complex composed of CD19, CR2/CD21, CD81 and IFITM1/CD225 in the membrane of mature B-cells. Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. Cell membrane ; Single-pass membrane protein Lysosome membrane Predominantly expressed in nascent primordial germ cells, as well as in gonadal germ cells. In migrating PGCs, expression is first detected during germ cell differentiation. Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity. Belongs to the CD225/Dispanin family. It has been previously shown that mediates migration of early primordial germ cells (PGCs) (PubMed:16326387). But according to PubMed:16326387, have no detectable effects on development of the germ line or on the generation of live young, hence, is not essential for PGC migration. ossification somitogenesis immune system process molecular_function early endosome plasma membrane negative regulation of cell proliferation response to virus anterior/posterior pattern specification membrane integral component of membrane negative regulation of cell migration macromolecular complex response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication innate immune response positive regulation of osteoblast differentiation negative regulation of viral entry into host cell defense response to virus type I interferon signaling pathway uc009kja.1 uc009kja.2 uc009kja.3 uc009kja.4 
ENSMUST00000106043.3 Fam229a ENSMUST00000106043.3 family with sequence similarity 229, member A (from RefSeq NM_001085491.2) B2KGE5 ENSMUST00000106043.1 ENSMUST00000106043.2 F229A_MOUSE NM_001085491 uc008uxd.1 uc008uxd.2 Belongs to the FAM229 family. molecular_function cellular_component biological_process uc008uxd.1 uc008uxd.2 
ENSMUST00000106045.8 Nlrp6 ENSMUST00000106045.8 Nlrp6 (from geneSymbol) E9QNS0 E9QNS0_MOUSE ENSMUST00000106045.1 ENSMUST00000106045.2 ENSMUST00000106045.3 ENSMUST00000106045.4 ENSMUST00000106045.5 ENSMUST00000106045.6 ENSMUST00000106045.7 FJ222825 Nlrp6 uc291wxw.1 uc291wxw.2 nucleotide binding ATP binding uc291wxw.1 uc291wxw.2 
ENSMUST00000106052.2 Zfp941 ENSMUST00000106052.2 zinc finger protein 941 (from RefSeq NM_001001180.2) BC066028 ENSMUST00000106052.1 NM_001001180 Q6NV92 Q6NV92_MOUSE Zfp941 uc009kie.1 uc009kie.2 uc009kie.3 Nucleus nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc009kie.1 uc009kie.2 uc009kie.3 
ENSMUST00000106054.4 Yars1 ENSMUST00000106054.4 tyrosyl-tRNA synthetase 1, transcript variant 2 (from RefSeq NR_160965.1) ENSMUST00000106054.1 ENSMUST00000106054.2 ENSMUST00000106054.3 NR_160965 Q3TEC8 Q3U9A1 Q3UTA7 Q8BVT2 Q8C183 Q91WQ3 SYYC_MOUSE Yars uc008uwk.1 uc008uwk.2 uc008uwk.3 uc008uwk.4 uc008uwk.5 Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine-- tRNA ligase activity (By similarity). Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:25533949). Reaction=ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L- tyrosyl-tRNA(Tyr); Xref=Rhea:RHEA:10220, Rhea:RHEA-COMP:9706, Rhea:RHEA-COMP:9707, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58315, ChEBI:CHEBI:78442, ChEBI:CHEBI:78536, ChEBI:CHEBI:456215; EC=6.1.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10221; Evidence=; Resveratrol strongly inhibits the tyrosine--tRNA ligase activity. Homodimer. Interacts (when binding to resveratrol) with PARP1; interaction stimulates the poly-ADP-ribosyltransferase activity of PARP1. Cytoplasm Nucleus Note=Cytoplasmic in normal conditions. Resveratrol-binding in response to serum starvation promotes relocalization to the nucleus. The nuclear localization signal, which mediates localization to the nucleus, is also important for interacting with tRNA(Tyr), suggesting that it is sterically blocked when tRNA(Tyr) is bound. Belongs to the class-I aminoacyl-tRNA synthetase family. tRNA binding nucleotide binding RNA binding aminoacyl-tRNA ligase activity tyrosine-tRNA ligase activity ATP binding cytoplasm cytosol translation tRNA aminoacylation for protein translation tyrosyl-tRNA aminoacylation nuclear body ligase activity uc008uwk.1 uc008uwk.2 uc008uwk.3 uc008uwk.4 uc008uwk.5 
ENSMUST00000106057.8 Zranb2 ENSMUST00000106057.8 zinc finger, RAN-binding domain containing 2, transcript variant 6 (from RefSeq NM_001410611.1) D3Z4U0 D3Z4U0_MOUSE ENSMUST00000106057.1 ENSMUST00000106057.2 ENSMUST00000106057.3 ENSMUST00000106057.4 ENSMUST00000106057.5 ENSMUST00000106057.6 ENSMUST00000106057.7 NM_001410611 Zranb2 uc290kvk.1 uc290kvk.2 Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. Nucleus Belongs to the ZRANB2 family. RNA binding nucleus metal ion binding uc290kvk.1 uc290kvk.2 
ENSMUST00000106061.9 S100pbp ENSMUST00000106061.9 S100P binding protein, transcript variant 1 (from RefSeq NM_029036.4) A2A7S5 ENSMUST00000106061.1 ENSMUST00000106061.2 ENSMUST00000106061.3 ENSMUST00000106061.4 ENSMUST00000106061.5 ENSMUST00000106061.6 ENSMUST00000106061.7 ENSMUST00000106061.8 NM_029036 Q3UJU0 Q3UTU1 Q3V367 Q8BSS8 Q8C925 Q8CHX8 Q9D5K4 S100pbp S1PBP_MOUSE uc008uwf.1 uc008uwf.2 uc008uwf.3 Interacts with S100P. Nucleus Note=Colocalizes with S100P in the nucleus. Event=Alternative splicing; Named isoforms=5; Name=1 ; IsoId=Q9D5K4-1; Sequence=Displayed; Name=2 ; IsoId=Q9D5K4-2; Sequence=VSP_052667, VSP_052668; Name=3 ; IsoId=Q9D5K4-3; Sequence=VSP_052663, VSP_052664; Name=4 ; IsoId=Q9D5K4-4; Sequence=VSP_052662, VSP_052664; Name=5 ; IsoId=Q9D5K4-5; Sequence=VSP_052663, VSP_052664, VSP_052665, VSP_052666; nucleus cytosol biological_process nuclear speck calcium-dependent protein binding uc008uwf.1 uc008uwf.2 uc008uwf.3 
ENSMUST00000106064.10 Tmem54 ENSMUST00000106064.10 transmembrane protein 54, transcript variant 1 (from RefSeq NM_025452.4) A2A7R3 ENSMUST00000106064.1 ENSMUST00000106064.2 ENSMUST00000106064.3 ENSMUST00000106064.4 ENSMUST00000106064.5 ENSMUST00000106064.6 ENSMUST00000106064.7 ENSMUST00000106064.8 ENSMUST00000106064.9 NM_025452 Q8VCL0 Q9D7S1 TMM54_MOUSE uc008uvz.1 uc008uvz.2 uc008uvz.3 uc008uvz.4 Membrane ; Multi-pass membrane protein Belongs to the TMEM54 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008uvz.1 uc008uvz.2 uc008uvz.3 uc008uvz.4 
ENSMUST00000106069.9 Adam8 ENSMUST00000106069.9 a disintegrin and metallopeptidase domain 8, transcript variant 1 (from RefSeq NM_007403.4) Adam8 ENSMUST00000106069.1 ENSMUST00000106069.2 ENSMUST00000106069.3 ENSMUST00000106069.4 ENSMUST00000106069.5 ENSMUST00000106069.6 ENSMUST00000106069.7 ENSMUST00000106069.8 NM_007403 Q3U1J7 Q3U1J7_MOUSE uc009kgj.1 uc009kgj.2 uc009kgj.3 This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]. Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. podosome metalloendopeptidase activity cytoplasm plasma membrane integral component of plasma membrane proteolysis inflammatory response integrin-mediated signaling pathway metallopeptidase activity cell surface membrane integral component of membrane regulation of cell-cell adhesion phagolysosome dense core granule membrane specific granule cell adhesion molecule binding positive regulation of membrane protein ectodomain proteolysis tertiary granule alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex cellular response to hypoxia positive regulation of neutrophil extravasation uc009kgj.1 uc009kgj.2 uc009kgj.3 
ENSMUST00000106072.9 Zfp362 ENSMUST00000106072.9 zinc finger protein 362, transcript variant 4 (from RefSeq NM_001419425.1) B1ASA5 B1ASA5_MOUSE ENSMUST00000106072.1 ENSMUST00000106072.2 ENSMUST00000106072.3 ENSMUST00000106072.4 ENSMUST00000106072.5 ENSMUST00000106072.6 ENSMUST00000106072.7 ENSMUST00000106072.8 NM_001419425 RP23-467J23.3-001 Zfp362 uc008uvn.1 uc008uvn.2 uc008uvn.3 molecular_function nucleic acid binding cellular_component biological_process uc008uvn.1 uc008uvn.2 uc008uvn.3 
ENSMUST00000106077.8 A3galt2 ENSMUST00000106077.8 Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures. Synthesis of iGb3 is the initial step in the formation of the isoglobo- series glycolipid pathway and is the precursor to isogloboside 4 (iGb4) and isoForssman glycolipids. Can glycosylate only lipids and not proteins and is solely responsible for initiating the synthesis of isoglobo-series glycosphingolipids. (from UniProt Q3V1N9) A3LT2_MOUSE AK132334 B2KGX5 B2KGX6 ENSMUST00000106077.1 ENSMUST00000106077.2 ENSMUST00000106077.3 ENSMUST00000106077.4 ENSMUST00000106077.5 ENSMUST00000106077.6 ENSMUST00000106077.7 Igb3s M9MMK2 Q3V1N9 uc290pzu.1 uc290pzu.2 Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures. Synthesis of iGb3 is the initial step in the formation of the isoglobo- series glycolipid pathway and is the precursor to isogloboside 4 (iGb4) and isoForssman glycolipids. Can glycosylate only lipids and not proteins and is solely responsible for initiating the synthesis of isoglobo-series glycosphingolipids. Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)- beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:13013, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:133507, ChEBI:CHEBI:138024; EC=2.4.1.87; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13014; Evidence=; Reaction=a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP- alpha-D-galactose = an isogloboside iGb3Cer (d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:42000, ChEBI:CHEBI:15378, ChEBI:CHEBI:17950, ChEBI:CHEBI:52570, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42001; Evidence=; Reaction=a globoside Gb3Cer + UDP-alpha-D-galactose = a globoside GalGb3Cer + H(+) + UDP; Xref=Rhea:RHEA:56740, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914, ChEBI:CHEBI:88154, ChEBI:CHEBI:140743; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56741; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mn(2+) ion per subunit. ; Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Note=Also found in numerous large vesicles throughout the cytoplasm of the soma. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3V1N9-1; Sequence=Displayed; Name=2; IsoId=Q3V1N9-2; Sequence=VSP_054297; Thymus and lung. The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity). Mice are fertile, develop normally and exhibit no overt behavioral abnormalities. However, compared to heterozygous mice they lack expression of the glycosphingolipid isoglobotrihexosylceramide (iGb3) in the dorsal root ganglion. Belongs to the glycosyltransferase 6 family. alpha-1,3-galactosyltransferase activity Golgi apparatus carbohydrate metabolic process glycosphingolipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups lipid glycosylation vesicle Golgi cisterna membrane metal ion binding N-acetyllactosaminide 3-alpha-galactosyltransferase activity cellular response to manganese ion uc290pzu.1 uc290pzu.2 
ENSMUST00000106079.10 Phc2 ENSMUST00000106079.10 polyhomeotic 2, transcript variant 3 (from RefSeq NM_001195083.1) B1AS98 B1ASA4 ENSMUST00000106079.1 ENSMUST00000106079.2 ENSMUST00000106079.3 ENSMUST00000106079.4 ENSMUST00000106079.5 ENSMUST00000106079.6 ENSMUST00000106079.7 ENSMUST00000106079.8 ENSMUST00000106079.9 Edr2 NM_001195083 O88463 PHC2_MOUSE Ph2 Q8K5D9 Q9QWH1 uc008uvk.1 uc008uvk.2 uc008uvk.3 uc008uvk.4 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex. Interacts with CBX4 (By similarity). Interacts with BMI1, PCGF2, PHC1 and RNF2 (PubMed:9627119, PubMed:16024804, PubMed:27827373). Interacts with CHTOP (PubMed:22872859). Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2 (By similarity). Q9QWH1; P25916: Bmi1; NbExp=3; IntAct=EBI-642357, EBI-927401; Q9QWH1; P49138: Mapkapk2; NbExp=5; IntAct=EBI-642357, EBI-298776; Q9QWH1; P23798: Pcgf2; NbExp=5; IntAct=EBI-642357, EBI-926857; Q9QWH1; Q64028: Phc1; NbExp=2; IntAct=EBI-642357, EBI-927346; Q9QWH1; O35730: Ring1; NbExp=2; IntAct=EBI-642357, EBI-929310; Q9QWH1; Q9CQJ4: Rnf2; NbExp=7; IntAct=EBI-642357, EBI-927321; Q9QWH1; P49137: MAPKAPK2; Xeno; NbExp=2; IntAct=EBI-642357, EBI-993299; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QWH1-1; Sequence=Displayed; Name=2; IsoId=Q9QWH1-2; Sequence=VSP_016919; Isoform 2 is ubiquitously expressed in embryos and adult tissues at much higher level than isoform 1. Detected at 11.5 dpc in the developing brain, in the ventricular zones of the cortex and ganglionic eminences as well as in adult, in mature structures such as the granule cell layer of the dentate gyrus and cerebellum. HD1 motif interacts with SAM domain of PHC1. Mice are viable and fertile but show posterior transformations of the axial skeleton and premature senescence of mouse embryonic fibroblast associated with derepression of Hox cluster genes and Cdkn2a genes, respectively. Mice lacking Phc2 and Phc1 die at an early gestational stage. Mice mutant for Phc1 and/or Phc2 demonstrate that Phc1 and Phc2 mutations affect synergistically the survival of embryos in a gene dosage-dependent manner and thus show functional redundancy of Phc1 and Phc2. heterochromatin DNA binding protein binding nucleus nucleoplasm multicellular organism development spermatogenesis zinc ion binding PcG protein complex PRC1 complex identical protein binding metal ion binding uc008uvk.1 uc008uvk.2 uc008uvk.3 uc008uvk.4 
ENSMUST00000106089.8 Metrnl ENSMUST00000106089.8 Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures. (from UniProt Q8VE43) BC024497 ENSMUST00000106089.1 ENSMUST00000106089.2 ENSMUST00000106089.3 ENSMUST00000106089.4 ENSMUST00000106089.5 ENSMUST00000106089.6 ENSMUST00000106089.7 METRL_MOUSE Q8R1J2 Q8VE43 uc288emr.1 uc288emr.2 Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VE43-1; Sequence=Displayed; Name=2; IsoId=Q8VE43-2; Sequence=VSP_025897; Highly expressed in subcutaneous adipose tissue. Up-regulated during adipogenesis and obesity. Induced either in muscle after exercise or in adipose tissue upon cold exposure (at protein level). Expression is induced by Ppargc1a isoform 4 (PubMed:24906147). N-glycosylated. Belongs to the meteorin family. hormone activity extracellular region extracellular space signal transduction response to cold response to muscle activity fat cell differentiation negative regulation of inflammatory response brown fat cell differentiation positive regulation of brown fat cell differentiation energy homeostasis uc288emr.1 uc288emr.2 
ENSMUST00000106090.8 Gjb4 ENSMUST00000106090.8 Structural component of gap junctions (PubMed:15692151). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:15692151). (from UniProt Q02738) AK076408 CXB4_MOUSE Cxn-30.3 ENSMUST00000106090.1 ENSMUST00000106090.2 ENSMUST00000106090.3 ENSMUST00000106090.4 ENSMUST00000106090.5 ENSMUST00000106090.6 ENSMUST00000106090.7 Q02738 uc033ieq.1 uc033ieq.2 uc033ieq.3 Structural component of gap junctions (PubMed:15692151). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:15692151). A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels (By similarity). Forms heteromeric channels with GJB2 (PubMed:15692151). Cell membrane ; Multi-pass membrane protein Cell junction, gap junction Note=Colocalizes with GJB2 at gap junction plaques in the cochlea. Detected in cochlea (at protein level) (PubMed:15692151). Detected in cochlea (PubMed:15692151). Expressed in skin (PubMed:1512260). Detected in cochlea after 15 dpc. Detected in the spiral limbus in neoneates at 2, 8 and 10 days after birth, before the onset of hearing. Belongs to the connexin family. Beta-type (group I) subfamily. gap junction channel activity protein binding nucleus nucleolus plasma membrane integral component of plasma membrane gap junction connexin complex cell communication cell-cell signaling sensory perception of smell membrane integral component of membrane cell junction olfactory behavior transmembrane transport gap junction-mediated intercellular transport uc033ieq.1 uc033ieq.2 uc033ieq.3 
ENSMUST00000106095.3 Nkx6-2 ENSMUST00000106095.3 NK6 homeobox 2, transcript variant 1 (from RefSeq NM_183248.4) D3Z4R4 D3Z4R4_MOUSE ENSMUST00000106095.1 ENSMUST00000106095.2 NM_183248 Nkx6-2 uc291wqz.1 uc291wqz.2 Nucleus negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated negative regulation of cell fate commitment positive regulation of cell fate commitment regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification central nervous system myelination cell differentiation endocrine pancreas development regulation of myelination sequence-specific DNA binding negative regulation of glial cell differentiation positive regulation of glial cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter oligodendrocyte differentiation neuromuscular process controlling balance uc291wqz.1 uc291wqz.2 
ENSMUST00000106098.8 Inpp5a ENSMUST00000106098.8 inositol polyphosphate-5-phosphatase A, transcript variant 1 (from RefSeq NM_001127363.1) E9QAS7 ENSMUST00000106098.1 ENSMUST00000106098.2 ENSMUST00000106098.3 ENSMUST00000106098.4 ENSMUST00000106098.5 ENSMUST00000106098.6 ENSMUST00000106098.7 I5P1_MOUSE NM_001127363 Q7TNC9 Q8BNK3 uc009kfr.1 uc009kfr.2 uc009kfr.3 Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:26051944). Plays a crucial role in the survival of cerebellar Purkinje cells (PubMed:26051944). Reaction=1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate; Xref=Rhea:RHEA:19797, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58282, ChEBI:CHEBI:203600; EC=3.1.3.56; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19798; Evidence=; Reaction=1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo- inositol 1,3,4-trisphosphate + phosphate; Xref=Rhea:RHEA:11392, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57895, ChEBI:CHEBI:58414; EC=3.1.3.56; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11393; Evidence=; Interacts with TASOR. Cell membrane ; Lipid-anchor Cell projection, dendrite Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TNC9-1; Sequence=Displayed; Name=2; IsoId=Q7TNC9-2; Sequence=VSP_060756; Expressed at high levels in cerebellar Purkinje cells (at protein level) (PubMed:26051944). Expressed in Sertoli cells of the testis (PubMed:31112734). Isoprenylation at Cys-409 is required for localization at the membrane. Genetic deletion causes a perinatal lethal phenotype in most mutant mice (PubMed:26051944). A small percentage of mutants thrive and have a phenotype characterized by an ataxic gait and progressive Purkinje cell degeneration (PubMed:26051944). Purkinje cell death is spatially patterned with surviving Purkinje cells appearing normal and maintaining molecular layer morphology (PubMed:26051944). Phosphatase activity toward phosphoinositol substrates is reduced in the mutant relative to wild-type littermates (PubMed:26051944). Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. inositol-polyphosphate 5-phosphatase activity membrane hydrolase activity PH domain binding inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation inositol phosphate-mediated signaling uc009kfr.1 uc009kfr.2 uc009kfr.3 
ENSMUST00000106099.8 Zmym1 ENSMUST00000106099.8 Zmym1 (from geneSymbol) A2A7T8 A2A7T8_MOUSE AK167508 ENSMUST00000106099.1 ENSMUST00000106099.2 ENSMUST00000106099.3 ENSMUST00000106099.4 ENSMUST00000106099.5 ENSMUST00000106099.6 ENSMUST00000106099.7 Zmym1 uc008uuf.1 uc008uuf.2 uc008uuf.3 biological_process zinc ion binding protein dimerization activity uc008uuf.1 uc008uuf.2 uc008uuf.3 
ENSMUST00000106103.8 Zzz3 ENSMUST00000106103.8 zinc finger, ZZ domain containing 3, transcript variant 4 (from RefSeq NM_001346655.1) ENSMUST00000106103.1 ENSMUST00000106103.2 ENSMUST00000106103.3 ENSMUST00000106103.4 ENSMUST00000106103.5 ENSMUST00000106103.6 ENSMUST00000106103.7 NM_001346655 Q3TMK6 Q3V189 Q6KAQ7 ZZZ3_MOUSE uc008rtm.1 uc008rtm.2 uc008rtm.3 Histone H3 reader that is required for the ATAC complex- mediated maintenance of histone acetylation and gene activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (By similarity). Interacts via (ZZ-type zinc finger) with histone H3 in a methylation-independent manner and acetylation on 'Lys-4' (H3K4ac) moderately enhances the interaction (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6KAQ7-1; Sequence=Displayed; Name=2; IsoId=Q6KAQ7-2; Sequence=VSP_025514, VSP_025517; Name=3; IsoId=Q6KAQ7-3; Sequence=VSP_025515, VSP_025516, VSP_025518; molecular_function DNA binding nucleus Ada2/Gcn5/Ada3 transcription activator complex nucleolus biological_process zinc ion binding metal ion binding uc008rtm.1 uc008rtm.2 uc008rtm.3 
ENSMUST00000106107.3 Rab40b ENSMUST00000106107.3 Rab40B, member RAS oncogene family, transcript variant 2 (from RefSeq NM_139147.4) ENSMUST00000106107.1 ENSMUST00000106107.2 NM_139147 Q8VHP8 RB40B_MOUSE uc007mvu.1 uc007mvu.2 uc007mvu.3 uc007mvu.4 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Cell membrane ; Lipid-anchor ; Cytoplasmic side The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity GTP binding nuclear envelope endosome plasma membrane intracellular protein transport synaptic vesicle membrane protein ubiquitination Rab protein signal transduction intracellular signal transduction perinuclear region of cytoplasm protein localization to plasma membrane multi-organism toxin transport uc007mvu.1 uc007mvu.2 uc007mvu.3 uc007mvu.4 
ENSMUST00000106108.9 Zmym4 ENSMUST00000106108.9 zinc finger, MYM-type 4, transcript variant 3 (from RefSeq NM_001379530.1) A2A791 ENSMUST00000106108.1 ENSMUST00000106108.2 ENSMUST00000106108.3 ENSMUST00000106108.4 ENSMUST00000106108.5 ENSMUST00000106108.6 ENSMUST00000106108.7 ENSMUST00000106108.8 Kiaa0425 NM_001379530 Q3UFQ2 Q6ZQB9 Q80X47 Q8K1H5 ZMYM4_MOUSE Zfp262 Znf262 uc008uty.1 uc008uty.2 uc008uty.3 uc008uty.4 uc008uty.5 uc008uty.6 Plays a role in the regulation of cell morphology and cytoskeletal organization. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2A791-1; Sequence=Displayed; Name=2; IsoId=A2A791-2; Sequence=VSP_027515; Sequence=BAC97947.1; Type=Erroneous initiation; Evidence=; Sequence=CAM19273.1; Type=Erroneous gene model prediction; Evidence=; RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription from RNA polymerase II promoter cytoskeleton organization zinc ion binding regulation of cell morphogenesis metal ion binding uc008uty.1 uc008uty.2 uc008uty.3 uc008uty.4 uc008uty.5 uc008uty.6 
ENSMUST00000106112.2 Bnip3 ENSMUST00000106112.2 BCL2/adenovirus E1B interacting protein 3 (from RefSeq NM_009760.4) BNIP3_MOUSE Bnip3 ENSMUST00000106112.1 NM_009760 Nip3 O55003 Q544Y4 uc009kfg.1 uc009kfg.2 Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway (By similarity). Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). Interacts with BOK; promotes BOK oligomerization. Mitochondrion. Mitochondrion outer membrane ; Single-pass membrane protein Note=Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane (By similarity). Belongs to the NIP3 family. response to hypoxia protein binding nucleus nuclear envelope nucleoplasm cytoplasm mitochondrion mitochondrial envelope mitochondrial outer membrane endoplasmic reticulum apoptotic process cell death granzyme-mediated apoptotic signaling pathway response to bacterium negative regulation of mitochondrial fusion cardiac muscle cell apoptotic process positive regulation of cardiac muscle cell apoptotic process regulation of mitochondrion organization negative regulation of mitochondrial membrane potential positive regulation of necrotic cell death postsynaptic density membrane integral component of membrane positive regulation of macroautophagy cerebral cortex development dendrite integral component of mitochondrial outer membrane mitochondrial membrane mitochondrial protein catabolic process identical protein binding protein homodimerization activity positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death positive regulation of protein complex disassembly mitochondrial fragmentation involved in apoptotic process negative regulation of membrane potential regulation of mitochondrial membrane permeability protein heterodimerization activity autophagic cell death oligodendrocyte differentiation brown fat cell differentiation GTPase binding neuron apoptotic process positive regulation of mitochondrial calcium ion concentration defense response to virus response to hyperoxia negative regulation of cell death cellular response to hydrogen peroxide cellular response to mechanical stimulus cellular response to cobalt ion cellular response to hypoxia reactive oxygen species metabolic process positive regulation of mitochondrial fission positive regulation of release of cytochrome c from mitochondria intrinsic apoptotic signaling pathway mitochondrial outer membrane permeabilization toxin transport negative regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of mitophagy regulation of aerobic respiration intrinsic apoptotic signaling pathway in response to hypoxia negative regulation of reactive oxygen species metabolic process uc009kfg.1 uc009kfg.2 
ENSMUST00000106113.2 Foxk2 ENSMUST00000106113.2 forkhead box K2, transcript variant 2 (from RefSeq NM_001363033.1) A2AN27 B5AZX0 ENSMUST00000106113.1 FOXK2_MOUSE Foxk2 Ilf1 NM_001363033 Q3UCQ1 uc011yjl.1 uc011yjl.2 uc011yjl.3 Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (PubMed:25402684, PubMed:29861159, PubMed:30700909). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:25402684, PubMed:29861159, PubMed:30700909). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (PubMed:30700909). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (PubMed:30700909). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (PubMed:30700909). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (PubMed:25402684). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co- associates with JUN/AP-1 to activate transcription (By similarity). Also able to bind to a minimal DNA heteroduplex containing a G/T- mismatch with 5'-TRT[G/T]NB-3' sequence (By similarity). Binds to NFAT- like motifs (purine-rich) in the IL2 promoter (By similarity). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (By similarity). Component of SIN3A-, but not SIN3B-, containing multiprotein complexes (PubMed:25402684). Interacts with DVL1, DVL2 (when phosphorylated) and DVL3; the interaction induces DVL2 nuclear translocation (By similarity). Interacts with SUDS3 (By similarity). Interacts with BAP1 (when phosphorylated); leading to recruit the PR- DUB complex and repress FOXK2 target genes (By similarity). Nucleus toplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UCQ1-1; Sequence=Displayed; Name=2 ; IsoId=Q3UCQ1-2; Sequence=VSP_052236; Expressed in a wide range of adult brain regions, namely the piriform cortex, the major islands of Calleja and cells lining the lateral ventricles, the bed nucleus of stria terminalis, the paraventricular thalamic nucleus, habenula and all structures of the hippocampus. Also present in the hypothalamus, cerebral cortex and in the Purkinje cell layer in the cerebellum. Additionally expressed in dopamine neurons of the substantia and more sparsely in the ventral tegmental area. At 12.5 dpc, expressed ubiquitously in the developing central nervous system. This pattern persists at 14.5 dpc and 16.5 dpc, with expression levels varying. The C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity. Hyperphosphorylated during mitosis by CDK1 and, to a lower extent, CDK2. Phosphorylation at Ser-364 and Ser-419 affects stability by promoting degradation. negative regulation of transcription from RNA polymerase II promoter magnesium ion binding transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cellular glucose homeostasis DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated negative regulation of autophagy regulation of glucose metabolic process regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter response to starvation sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding canonical glycolysis uc011yjl.1 uc011yjl.2 uc011yjl.3 
ENSMUST00000106117.8 Hexd ENSMUST00000106117.8 hexosaminidase D, transcript variant 2 (from RefSeq NM_001001333.2) B7UUP4 B7UUP5 ENSMUST00000106117.1 ENSMUST00000106117.2 ENSMUST00000106117.3 ENSMUST00000106117.4 ENSMUST00000106117.5 ENSMUST00000106117.6 ENSMUST00000106117.7 HEXD_MOUSE Hexdc NM_001001333 Q3U4H6 Q6NSQ8 uc033gcb.1 uc033gcb.2 uc033gcb.3 uc033gcb.4 Has hexosaminidase activity (PubMed:19040401). Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (By similarity). Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52; Evidence=; Inhibited by O-(2-acetamido-2-deoxy-D- glucopyranosylidene)amino N-phenylcarbamate (PUGNAc). Inhibited by galacto-NAG-thiazoline (By similarity). Kinetic parameters: KM=0.25 mM for p-nitrophenyl-beta-N-acetylgalactosaminide ; pH dependence: Optimum pH is 5.5. ; Temperature dependence: Optimum temperature is 37 degrees Celsius. ; Homodimer; disulfide-linked. Cytoplasm Nucleus Extracellular vesicle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U4H6-1; Sequence=Displayed; Name=2; IsoId=Q3U4H6-2; Sequence=VSP_030778; Ubiquitous. Belongs to the glycosyl hydrolase 20 family. Sequence=AAH69960.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; hydrolase activity, hydrolyzing O-glycosyl compounds beta-N-acetylhexosaminidase activity nucleus cytoplasm carbohydrate metabolic process metabolic process hexosaminidase activity hydrolase activity hydrolase activity, acting on glycosyl bonds extracellular vesicle uc033gcb.1 uc033gcb.2 uc033gcb.3 uc033gcb.4 
ENSMUST00000106134.4 Ttll7 ENSMUST00000106134.4 tubulin tyrosine ligase-like family, member 7, transcript variant 3 (from RefSeq NM_001357217.1) E9Q6C6 E9Q6C6_MOUSE ENSMUST00000106134.1 ENSMUST00000106134.2 ENSMUST00000106134.3 NM_001357217 Ttll7 uc290kli.1 uc290kli.2 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; ATP binding cellular protein modification process uc290kli.1 uc290kli.2 
ENSMUST00000106153.9 Ssx2ip ENSMUST00000106153.9 SSX family member 2 interacting protein, transcript variant 1 (from RefSeq NM_138744.4) ADIP_MOUSE ENSMUST00000106153.1 ENSMUST00000106153.2 ENSMUST00000106153.3 ENSMUST00000106153.4 ENSMUST00000106153.5 ENSMUST00000106153.6 ENSMUST00000106153.7 ENSMUST00000106153.8 NM_138744 Q8BG59 Q8C7X0 Q8K2F7 Q8VC66 uc008rrd.1 uc008rrd.2 uc008rrd.3 uc008rrd.4 uc008rrd.5 Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin- catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha- actinin (PubMed:12446711). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (PubMed:22027834). Involved in ciliogenesis (By similarity). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (By similarity). Interacts with SSX2 and SSX3 (By similarity). Does not interact with SSX1 and SSX4 (By similarity). Interacts with afadin and alpha-actinin (PubMed:12446711). Interacts with VAV2 (PubMed:22027834). Interacts with PCM1 (PubMed:24356449). Interacts with WRAP73 (By similarity). Q8VC66; P12814: ACTN1; Xeno; NbExp=3; IntAct=EBI-6654049, EBI-351710; Q8VC66; O35889: Afdn; Xeno; NbExp=4; IntAct=EBI-6654049, EBI-6654073; Q8VC66; Q9P2S5: WRAP73; Xeno; NbExp=4; IntAct=EBI-6654049, EBI-1054904; Cell junction, adherens junction Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cytoplasm, cytoskeleton, cilium basal body Note=Not found at cell-matrix AJs. Widely expressed. Belongs to the ADIP family. protein binding nucleus cytoplasm microtubule organizing center cytoskeleton adherens junction cell-cell adherens junction centrosome cycle cell adhesion protein domain specific binding cell projection organization cell junction cell leading edge macromolecular complex centriolar satellite regulation of Rac protein signal transduction intraciliary transport involved in cilium assembly ciliary basal body cell projection cilium assembly regulation of cell motility uc008rrd.1 uc008rrd.2 uc008rrd.3 uc008rrd.4 uc008rrd.5 
ENSMUST00000106157.8 Zranb1 ENSMUST00000106157.8 zinc finger, RAN-binding domain containing 1, transcript variant 1 (from RefSeq NM_207302.3) ENSMUST00000106157.1 ENSMUST00000106157.2 ENSMUST00000106157.3 ENSMUST00000106157.4 ENSMUST00000106157.5 ENSMUST00000106157.6 ENSMUST00000106157.7 NM_207302 Q7M760 Trabid ZRAN1_MOUSE Zranb1 uc009kcv.1 uc009kcv.2 uc009kcv.3 uc009kcv.4 Ubiquitin thioesterase, which specifically hydrolyzes 'Lys- 29'-linked and 'Lys-33'-linked diubiquitin (By similarity). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity). Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (By similarity). Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required in the stress fiber dynamics and cell migration (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with TRAF6. Interacts with APC. Cytoplasm Nucleus Note=Enriched in punctate localization in the cytoplasm. The RanBP2-type zinc fingers, also called NZFs, mediate the interaction with ubiquitin and determine linkage specificity. RanBP2- type zinc fingers 1 and 2 (also named NZF1 and NZF2) specifically recognize and bind 'Lys-29'- and 'Lys-33'-linked ubiquitin. RanBP2-type zinc finger 3 (also named NZF3) binds 'Lys-33'-linked ubiquitin and shows weak binding to 'Lys-6'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin chains but it does not interact with 'Lys-29'-linked chains. The OTU domain mediates the deubiquitinating activity. The second ankyrin repeat ANK 2 is termed AnkUBD, it interacts with ubiquitin hydrophobic patch and contributes to linkage specificity. Belongs to the peptidase C64 family. thiol-dependent ubiquitin-specific protease activity nucleus nucleoplasm cytoplasm cytosol proteolysis cytoskeleton organization peptidase activity cysteine-type peptidase activity Wnt signaling pathway cell migration hydrolase activity regulation of cell morphogenesis positive regulation of Wnt signaling pathway protein K29-linked deubiquitination thiol-dependent ubiquitinyl hydrolase activity intracellular membrane-bounded organelle metal ion binding K63-linked polyubiquitin binding protein K63-linked deubiquitination protein deubiquitination involved in ubiquitin-dependent protein catabolic process protein K33-linked deubiquitination uc009kcv.1 uc009kcv.2 uc009kcv.3 uc009kcv.4 
ENSMUST00000106162.8 Csf3r ENSMUST00000106162.8 colony stimulating factor 3 receptor, transcript variant 13 (from RefSeq NR_185214.1) A2A8Y3 CSF3R_MOUSE Csfgr ENSMUST00000106162.1 ENSMUST00000106162.2 ENSMUST00000106162.3 ENSMUST00000106162.4 ENSMUST00000106162.5 ENSMUST00000106162.6 ENSMUST00000106162.7 NR_185214 P40223 uc008usd.1 uc008usd.2 uc008usd.3 uc008usd.4 uc008usd.5 Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface. Homodimer. The dimeric receptor binds two CSF3 molecules. Interacts with CEACAM1; down-regulates the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (PubMed:21029969). Membrane; Single-pass type I membrane protein. Found in bone marrow. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. N-glycosylated. Belongs to the type I cytokine receptor family. Type 2 subfamily. cytokine receptor activity protein binding cell adhesion external side of plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway cytokine binding neutrophil chemotaxis receptor complex regulation of myeloid cell differentiation granulocyte colony-stimulating factor binding amelogenesis uc008usd.1 uc008usd.2 uc008usd.3 uc008usd.4 uc008usd.5 
ENSMUST00000106178.9 Notum ENSMUST00000106178.9 notum palmitoleoyl-protein carboxylesterase, transcript variant 1 (from RefSeq NM_175263.4) A2ABZ5 A2ABZ6 ENSMUST00000106178.1 ENSMUST00000106178.2 ENSMUST00000106178.3 ENSMUST00000106178.4 ENSMUST00000106178.5 ENSMUST00000106178.6 ENSMUST00000106178.7 ENSMUST00000106178.8 NM_175263 NOTUM_MOUSE Notum Q8R116 uc007mtz.1 uc007mtz.2 uc007mtz.3 uc007mtz.4 uc007mtz.5 Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. Reaction=[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = (9Z)- hexadecenoate + [Wnt protein]-L-serine + H(+); Xref=Rhea:RHEA:45340, Rhea:RHEA-COMP:11170, Rhea:RHEA-COMP:11171, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:32372, ChEBI:CHEBI:85189; EC=3.1.1.98; Evidence=; Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R116-1; Sequence=Displayed; Name=2; IsoId=Q8R116-2; Sequence=VSP_031295, VSP_031296; Widely expressed. Expressed in lung, ovary, kidney, liver and brain. Not detected in thymus, heart, spleen, stomach, skeletal muscle and bone marrow. Belongs to the pectinacetylesterase family. Notum subfamily. The molecular function of NOTUM has remained unclear for many years. It was initially thought to hydrolyze glycosaminoglycan (GAG) chains of glypicans, thereby affecting glypicans ability to interact with Wnt ligands. It was later reported to trigger glypican shedding, by mediating cleavage of their GPI-anchor (PubMed:17967162). However, while NOTUM specifically inhibit the Wnt signaling pathway, more pleiotropic effects would be expected from an enzyme affecting glypicans. It was finally shown that it requires glypicans to suppress Wnt signaling, but does not cleave their GPI-anchor. It acts by mediating depalmitoleoylation of WNT proteins, impairing WNT binding to frizzled receptors. cellular_component extracellular region Wnt signaling pathway hydrolase activity negative regulation of Wnt signaling pathway carboxylic ester hydrolase activity negative regulation of canonical Wnt signaling pathway protein depalmitoleylation palmitoleyl hydrolase activity GPI anchor release uc007mtz.1 uc007mtz.2 uc007mtz.3 uc007mtz.4 uc007mtz.5 
ENSMUST00000106188.4 Pcyt2 ENSMUST00000106188.4 phosphate cytidylyltransferase 2, ethanolamine, transcript variant 2 (from RefSeq NM_001347615.2) A2ABY3 A2ABY3_MOUSE ENSMUST00000106188.1 ENSMUST00000106188.2 ENSMUST00000106188.3 NM_001347615 Pcyt2 uc007mtq.1 uc007mtq.2 uc007mtq.3 Lipid metabolism. Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3. Belongs to the cytidylyltransferase family. catalytic activity biosynthetic process transferase activity nucleotidyltransferase activity uc007mtq.1 uc007mtq.2 uc007mtq.3 
ENSMUST00000106190.10 1110065P20Rik ENSMUST00000106190.10 RIKEN cDNA 1110065P20 gene, transcript variant 3 (from RefSeq NM_001404054.1) B1ARW8 CA122_MOUSE ENSMUST00000106190.1 ENSMUST00000106190.2 ENSMUST00000106190.3 ENSMUST00000106190.4 ENSMUST00000106190.5 ENSMUST00000106190.6 ENSMUST00000106190.7 ENSMUST00000106190.8 ENSMUST00000106190.9 NM_001404054 uc057lkd.1 uc057lkd.2 uc057lkd.3 molecular_function cellular_component biological_process uc057lkd.1 uc057lkd.2 uc057lkd.3 
ENSMUST00000106193.8 Mtf1 ENSMUST00000106193.8 Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:24529376). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (By similarity). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (PubMed:24529376). (from UniProt Q07243) AK030284 ENSMUST00000106193.1 ENSMUST00000106193.2 ENSMUST00000106193.3 ENSMUST00000106193.4 ENSMUST00000106193.5 ENSMUST00000106193.6 ENSMUST00000106193.7 MTF1_MOUSE Mtf-1 Q07243 Q9JJW8 uc290psu.1 uc290psu.2 Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:24529376). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (By similarity). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (PubMed:24529376). Nucleus Cytoplasm Note=Translocation to the nucleus is induced by metals. Ubiquitously expressed. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm response to oxidative stress central nervous system development histone acetyltransferase binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to cadmium ion metal ion binding uc290psu.1 uc290psu.2 
ENSMUST00000106195.3 Npb ENSMUST00000106195.3 neuropeptide B, transcript variant 1 (from RefSeq NM_153288.3) ENSMUST00000106195.1 ENSMUST00000106195.2 NM_153288 NPB_MOUSE Q8K4P1 uc007mto.1 uc007mto.2 uc007mto.3 Has an effect in food intake, on locomotor activity and has an analgesic effect, (in vivo pharmacological studies). May be involved in the regulation of neuroendocrine system, memory and learning (By similarity). Secreted. Detected in brain; more specifically in paraventricular hypothalamic nucleus, hippocampus and several nuclei in midbrain and brainstem. Belongs to the neuropeptide B/W family. G-protein coupled receptor binding extracellular region extracellular space G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway neuropeptide signaling pathway uc007mto.1 uc007mto.2 uc007mto.3 
ENSMUST00000106197.10 Arhgdia ENSMUST00000106197.10 Rho GDP dissociation inhibitor alpha, transcript variant 1 (from RefSeq NM_133796.8) C87222 ENSMUST00000106197.1 ENSMUST00000106197.2 ENSMUST00000106197.3 ENSMUST00000106197.4 ENSMUST00000106197.5 ENSMUST00000106197.6 ENSMUST00000106197.7 ENSMUST00000106197.8 ENSMUST00000106197.9 GDIR1_MOUSE Gdi1 NM_133796 Q5M9P6 Q8BPI0 Q99KC4 Q99PT1 uc007mtk.1 uc007mtk.2 uc007mtk.3 uc007mtk.4 Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. Monomer (PubMed:22628549). Interacts with FER (By similarity). Interacts with PLXNB3 (PubMed:20696765). Forms a heterodimer with RAC1 (PubMed:23434736). Interacts with RHOA, the affinity is increased by three orders of magnitude when RHOA is prenylated (PubMed:23434736). Interacts with PSMD10; the interaction increases ARHGDIA association with RHOA, leading to ARHGDIA-mediated inactivation of RHOA and ROCK and prolonged AKT activation (By similarity). Interacts with KANK2; the interaction is direct and may regulate the interaction of ARHGDIA with RHOA, RAC1 and CDC42 (By similarity). Interacts with RHOC (By similarity). Interacts with CDC42 (PubMed:23434736). Interacts with NGFR (via death domain); NGFR binding decreases the affinity for RHOA (By similarity). Q99PT1; P60764: Rac3; NbExp=3; IntAct=EBI-494354, EBI-644949; Cytoplasm In kidney glomerulus, expressed in podocytes and mesangial cells. From 1 week to 12 weeks of age, progressive deterioration from mild to massive albuminuria as consequence of renal abnormalities. In kidney, severe podocyte damage, glomerular lesions with focal and segmental sclerosis, along with prominent intratubular casts and luminal dilatation. Tubular epithelial cells show degenerative changes with basement membrane thickening. Increase of apoptotic cells in kidney glomeruli and tubulointerstitium. Belongs to the Rho GDI family. immunological synapse Rho GDP-dissociation inhibitor activity GTPase activator activity fatty acid binding protein binding extracellular space nucleus cytoplasm cytosol Rho protein signal transduction regulation of cell shape membrane Rho GTPase binding protein kinase binding negative regulation of cell migration regulation of protein localization regulation of Rho protein signal transduction positive regulation of GTPase activity synapse Rac GTPase binding regulation of catalytic activity Hsp90 protein binding cellular response to mechanical stimulus cellular response to organic cyclic compound cellular response to redox state semaphorin-plexin signaling pathway regulation of actin cytoskeleton reorganization uc007mtk.1 uc007mtk.2 uc007mtk.3 uc007mtk.4 
ENSMUST00000106203.9 Hgs ENSMUST00000106203.9 HGF-regulated tyrosine kinase substrate, transcript variant 1 (from RefSeq NM_001159328.1) B1ATZ1 ENSMUST00000106203.1 ENSMUST00000106203.2 ENSMUST00000106203.3 ENSMUST00000106203.4 ENSMUST00000106203.5 ENSMUST00000106203.6 ENSMUST00000106203.7 ENSMUST00000106203.8 Hgs NM_001159328 Q3UMA3 Q3UMA3_MOUSE uc288efs.1 uc288efs.2 uc288efs.3 Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. Cytoplasm Early endosome membrane eripheral membrane protein ; Cytoplasmic side dosome, multivesicular body membrane ; Peripheral membrane protein cytoplasm lysosome endosome early endosome cytosol protein targeting to lysosome intracellular protein transport membrane invagination positive regulation of gene expression negative regulation of platelet-derived growth factor receptor signaling pathway protein transport membrane negative regulation of angiogenesis protein domain specific binding negative regulation of vascular endothelial growth factor receptor signaling pathway early endosome membrane multivesicular body membrane ESCRT-0 complex intracellular membrane-bounded organelle regulation of MAP kinase activity ubiquitin-like protein ligase binding negative regulation of JAK-STAT cascade metal ion binding protein localization to membrane positive regulation of exosomal secretion uc288efs.1 uc288efs.2 uc288efs.3 
ENSMUST00000106222.9 Gbp3 ENSMUST00000106222.9 guanylate binding protein 3, transcript variant 2 (from RefSeq NM_018734.4) ENSMUST00000106222.1 ENSMUST00000106222.2 ENSMUST00000106222.3 ENSMUST00000106222.4 ENSMUST00000106222.5 ENSMUST00000106222.6 ENSMUST00000106222.7 ENSMUST00000106222.8 GBP3_MOUSE Gbp3 NM_018734 Q61107 Q8VEC5 uc008rov.1 uc008rov.2 uc008rov.3 Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:24739961, PubMed:24715728). Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product (PubMed:9659399). Following infection, recruited to the pathogen- containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24739961, PubMed:24715728). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24739961, PubMed:24715728). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24739961, PubMed:24715728). May play a role in erythroid differentiation (PubMed:9659399). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; Kinetic parameters: KM=77.0 uM for GTP ; Vmax=21 pmol/min/ug enzyme ; Heterodimer with other family members, including GBP1, GBP2 and GBP5. Dimerization regulates subcellular location. Cytoplasm Cytoplasm, perinuclear region Golgi apparatus membrane Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus. Brain, lung, heart, spleen, kidney, liver and intestine. By IFNG/IFN-gamma, IFNB1/IFN-beta and TNF-alpha (PubMed:9659399, PubMed:18025219). Up-regulated upon infection by T.gondii or L.monocytogenes (PubMed:18025219). Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily. Golgi membrane nucleotide binding GTPase activity GTP binding nucleus cytoplasm Golgi apparatus cytosol membrane hydrolase activity symbiont-containing vacuole membrane cytoplasmic vesicle cellular response to interferon-beta protein homodimerization activity defense response to protozoan adhesion of symbiont to host perinuclear region of cytoplasm defense response to Gram-positive bacterium cellular response to interferon-gamma uc008rov.1 uc008rov.2 uc008rov.3 
ENSMUST00000106223.4 Ndufaf8 ENSMUST00000106223.4 NADH:ubiquinone oxidoreductase complex assembly factor 8 (from RefSeq NM_001110242.1) A2AMZ4 B2RWC2 ENSMUST00000106223.1 ENSMUST00000106223.2 ENSMUST00000106223.3 NDUF8_MOUSE NM_001110242 Ndufaf8 uc007mru.1 uc007mru.2 uc007mru.3 uc007mru.4 Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1). Required to stabilize NDUFAF5. Interacts with NDUFAF5. Mitochondrion molecular_function mitochondrion mitochondrial respiratory chain complex I assembly uc007mru.1 uc007mru.2 uc007mru.3 uc007mru.4 
ENSMUST00000106224.9 Macf1 ENSMUST00000106224.9 microtubule-actin crosslinking factor 1, transcript variant 1 (from RefSeq NM_001199136.2) B1ARU4 B1ARU4_MOUSE E9PVY8 ENSMUST00000106224.1 ENSMUST00000106224.2 ENSMUST00000106224.3 ENSMUST00000106224.4 ENSMUST00000106224.5 ENSMUST00000106224.6 ENSMUST00000106224.7 ENSMUST00000106224.8 Macf1 NM_001199136 uc290pqn.1 uc290pqn.2 uc290pqn.3 Cytoplasm, cytoskeleton Belongs to the plakin or cytolinker family. actin binding calcium ion binding cytoskeleton cytoskeleton organization microtubule binding cytoskeletal protein binding uc290pqn.1 uc290pqn.2 uc290pqn.3 
ENSMUST00000106227.8 Cep131 ENSMUST00000106227.8 centrosomal protein 131, transcript variant 1 (from RefSeq NM_009734.4) Azi1 B1AXI9 B1AXI9_MOUSE Cep131 ENSMUST00000106227.1 ENSMUST00000106227.2 ENSMUST00000106227.3 ENSMUST00000106227.4 ENSMUST00000106227.5 ENSMUST00000106227.6 ENSMUST00000106227.7 NM_009734 uc007mrp.1 uc007mrp.2 uc007mrp.3 The protein encoding this gene is a centriolar satellite protein that localizes around the basal body via transport along microtubules. Knockdown in mouse fibroblasts results in a reduction in ciliogenesis. Null mutant mice display no discernible ciliary phenotypes and embryonic patterning and adult homeostasis are largely unaffected. Male mice are infertile, however, due to defects in microtubule trafficking in the sperm manchette and flagella. In addition, the protein binds to a complex of proteins associated with Bardet-Biedl syndrome called the BBSome, and depletion of this protein results in an accumulation of the BBSome in cilia. [provided by RefSeq, Oct 2014]. CCDS Note: The coding region has been updated to represent alternative splice sites at the exon 9-10 splice junction. The update is supported by transcripts that support the reference genome allele, which lacks a TAC triplet in exon 10. ##Evidence-Data-START## Transcript exon combination :: AK133245.1, BC141108.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## centrosome microtubule organizing center positive regulation of cell proliferation regulation of centrosome duplication microtubule cytoskeleton centriolar satellite intraciliary transport involved in cilium assembly ciliary transition zone ciliary basal body protein homodimerization activity intracellular membrane-bounded organelle macromolecular complex binding intercellular bridge protein localization to centrosome positive regulation of intracellular protein transport uc007mrp.1 uc007mrp.2 uc007mrp.3 
ENSMUST00000106230.2 Bmpr1b ENSMUST00000106230.2 bone morphogenetic protein receptor, type 1B, transcript variant 3 (from RefSeq NM_001277217.3) Acvrlk6 BMR1B_MOUSE ENSMUST00000106230.1 NM_001277217 P36898 Q3TRF2 uc008roj.1 uc008roj.2 uc008roj.3 uc008roj.4 This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type I receptor, and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important in skeletal and bone development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z23143.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1. Receptor for GDF5 (PubMed:26105076, PubMed:19229295). Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA- COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44881; Evidence=; Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18674; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Interacts with high affinity with GDF5; positively regulates chondrocyte differentiation (By similarity). Interacts with SCUBE3 (By similarity). Interacts with TSC22D1/TSC-22 (By similarity). P36898; O35182: Smad6; NbExp=2; IntAct=EBI-7107883, EBI-4321242; Cell membrane ingle-pass type I membrane protein Autophosphorylated. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. nucleotide binding skeletal system development cartilage condensation ovarian cumulus expansion eye development chondrocyte differentiation chondrocyte development protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I protein binding ATP binding plasma membrane integral component of plasma membrane protein phosphorylation estrogen biosynthetic process inflammatory response transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway pattern specification process dorsal/ventral pattern formation membrane integral component of membrane kinase activity phosphorylation transferase activity growth factor binding cell differentiation proteoglycan biosynthetic process dendrite positive regulation of bone mineralization BMP signaling pathway retinal ganglion cell axon guidance positive regulation of chondrocyte differentiation limb morphogenesis ovulation cycle camera-type eye development neuronal cell body receptor complex positive regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter SMAD binding metal ion binding cartilage development retina development in camera-type eye endochondral bone morphogenesis positive regulation of cartilage development cellular response to growth factor stimulus cellular response to BMP stimulus positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of chondrocyte proliferation uc008roj.1 uc008roj.2 uc008roj.3 uc008roj.4 
ENSMUST00000106233.2 Baiap2 ENSMUST00000106233.2 Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. (from UniProt B1AZ46) AK049469 B1AZ46 B1AZ46_MOUSE Baiap2 ENSMUST00000106233.1 uc288eco.1 uc288eco.2 Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. Cell projection, filopodium Cell projection, ruffle Cytoplasm, cytoskeleton Membrane ; Peripheral membrane protein plasma membrane organization cytoskeletal adaptor activity regulation of actin cytoskeleton organization uc288eco.1 uc288eco.2 
ENSMUST00000106242.10 Itgam ENSMUST00000106242.10 integrin alpha M, transcript variant 2 (from RefSeq NM_008401.2) E9Q604 E9Q604_MOUSE ENSMUST00000106242.1 ENSMUST00000106242.2 ENSMUST00000106242.3 ENSMUST00000106242.4 ENSMUST00000106242.5 ENSMUST00000106242.6 ENSMUST00000106242.7 ENSMUST00000106242.8 ENSMUST00000106242.9 Itgam NM_008401 uc009jxz.1 uc009jxz.2 uc009jxz.3 Membrane ingle-pass type I membrane protein Belongs to the integrin alpha chain family. cell adhesion integrin-mediated signaling pathway integrin complex membrane integral component of membrane uc009jxz.1 uc009jxz.2 uc009jxz.3 
ENSMUST00000106243.8 Pabpc4 ENSMUST00000106243.8 poly(A) binding protein, cytoplasmic 4, transcript variant 3 (from RefSeq NM_001356377.1) A3KFU5 A3KFU5_MOUSE ENSMUST00000106243.1 ENSMUST00000106243.2 ENSMUST00000106243.3 ENSMUST00000106243.4 ENSMUST00000106243.5 ENSMUST00000106243.6 ENSMUST00000106243.7 NM_001356377 Pabpc4 uc008upe.1 uc008upe.2 uc008upe.3 uc008upe.4 uc008upe.5 Binds the poly(A) tail of mRNA. Cytoplasm Nucleus Belongs to the polyadenylate-binding protein type-1 family. nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding nucleus cytoplasm cytosol poly(A) binding poly(U) RNA binding cytoplasmic stress granule regulation of mRNA stability myeloid cell development ribonucleoprotein complex poly(C) RNA binding uc008upe.1 uc008upe.2 uc008upe.3 uc008upe.4 uc008upe.5 
ENSMUST00000106244.9 Endov ENSMUST00000106244.9 endonuclease V, transcript variant 5 (from RefSeq NR_174994.1) B1ATE4 ENDOV_MOUSE ENSMUST00000106244.1 ENSMUST00000106244.2 ENSMUST00000106244.3 ENSMUST00000106244.4 ENSMUST00000106244.5 ENSMUST00000106244.6 ENSMUST00000106244.7 ENSMUST00000106244.8 NR_174994 Q3TCQ4 Q8C3Y1 Q8C9A2 uc007mqt.1 uc007mqt.2 uc007mqt.3 uc007mqt.4 Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Has strong preference for single-stranded RNAs (ssRNAs) toward double- stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Monomer. Interacts with PABPC1; the interaction is RNA- dependent and stimulates ENDOV activity. Cytoplasm Nucleus, nucleolus Cytoplasm, Stress granule Note=Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with PABPC1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C9A2-3; Sequence=Displayed; Name=2; IsoId=Q8C9A2-1; Sequence=VSP_041579; Highest levels detected in liver with high levels also found in heart, kidney and testis. Expressed at low levels in brain. Was initially characterized as an endodeoxyribonuclease involved in DNA repair (PubMed:12853604). While it shows some weak endodeoxyribonuclease activity in vitro, such activity probably does not exist in vivo. Belongs to the endonuclease V family. Sequence=BAC39216.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; magnesium ion binding DNA binding RNA binding single-stranded RNA binding nuclease activity endonuclease activity nucleus nucleolus cytoplasm DNA repair hydrolase activity endodeoxyribonuclease activity, producing 5'-phosphomonoesters endoribonuclease activity, producing 5'-phosphomonoesters metal ion binding nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc007mqt.1 uc007mqt.2 uc007mqt.3 uc007mqt.4 
ENSMUST00000106247.2 Adh6a ENSMUST00000106247.2 alcohol dehydrogenase 6A (class V) (from RefSeq NM_026945.1) Adh6a E9Q5Z6 E9Q5Z6_MOUSE ENSMUST00000106247.1 NM_026945 uc008rng.1 uc008rng.2 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Cytoplasm Belongs to the zinc-containing alcohol dehydrogenase family. alcohol dehydrogenase activity, zinc-dependent retinol dehydrogenase activity cytosol ethanol oxidation zinc ion binding oxidoreductase activity retinol metabolic process retinoic acid metabolic process metal ion binding oxidation-reduction process uc008rng.1 uc008rng.2 
ENSMUST00000106248.8 Trim72 ENSMUST00000106248.8 Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)- dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles. (from UniProt Q1XH17) AB231474 B2RWH7 ENSMUST00000106248.1 ENSMUST00000106248.2 ENSMUST00000106248.3 ENSMUST00000106248.4 ENSMUST00000106248.5 ENSMUST00000106248.6 ENSMUST00000106248.7 Mg53 Q1XH17 Q6NX76 TRI72_MOUSE Trim72 uc291wae.1 uc291wae.2 Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)- dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles. Homooligomer; disulfide-linked. Interacts with DYSF and CAV3. Q1XH17; P15208: Insr; NbExp=2; IntAct=EBI-16034016, EBI-6999015; Q1XH17; P35569: Irs1; NbExp=4; IntAct=EBI-16034016, EBI-400825; Q1XH17; P06213-1: INSR; Xeno; NbExp=2; IntAct=EBI-16034016, EBI-15558981; Cell membrane, sarcolemma. Cytoplasmic vesicle membrane. Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine. Muscle-specific. Exclusively expressed in cardiac and skeletal muscle. Disulfide bond formation at Cys-242 occurs in case of membrane damage that cause the entry of the oxidized milieu of the extracellular space, resulting in homooligomerization. S-nitrosylation at Cys-144 stabilizes TRIM72 and protects against oxidation-induced protein degradation and cell death. Viable until at least 11 months of age under unstressed conditions, and develop progressive muscle pathology with age. Mice show progressive myopathy and reduced exercise capability, associated with defective membrane-repair capacity. Belongs to the TRIM/RBCC family. plasma membrane repair phosphatidylserine binding muscle system process protein binding plasma membrane exocytosis membrane budding muscle organ development zinc ion binding negative regulation of myotube differentiation membrane protein ubiquitination cytoplasmic vesicle membrane cytoplasmic vesicle ubiquitin conjugating enzyme binding sarcolemma proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of insulin-like growth factor receptor signaling pathway negative regulation of insulin receptor signaling pathway metal ion binding protein homooligomerization ubiquitin protein ligase activity uc291wae.1 uc291wae.2 
ENSMUST00000106250.8 Card14 ENSMUST00000106250.8 caspase recruitment domain family, member 14 (from RefSeq NM_130886.4) Bimp2 CAR14_MOUSE ENSMUST00000106250.1 ENSMUST00000106250.2 ENSMUST00000106250.3 ENSMUST00000106250.4 ENSMUST00000106250.5 ENSMUST00000106250.6 ENSMUST00000106250.7 NM_130886 Q99KF0 uc007mqk.1 uc007mqk.2 uc007mqk.3 Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Interacts (via CARD domain) with BCL10 (via CARD domain). Forms a complex with MALT1 and BCL10; resulting in the formation of a CBM (CARD14-BLC10-MALT1) complex. Interacts with TRAF2, TRAF3 and TRAF6. Cytoplasm A linker region between the coiled-coil and PDZ region holds the protein in an inactive state. Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART. positive regulation of protein phosphorylation cytoplasm apoptotic process tumor necrosis factor-mediated signaling pathway regulation of apoptotic process negative regulation of apoptotic process CARD domain binding positive regulation of NF-kappaB transcription factor activity uc007mqk.1 uc007mqk.2 uc007mqk.3 
ENSMUST00000106251.10 Fus ENSMUST00000106251.10 fused in sarcoma, transcript variant 1 (from RefSeq NM_139149.2) ENSMUST00000106251.1 ENSMUST00000106251.2 ENSMUST00000106251.3 ENSMUST00000106251.4 ENSMUST00000106251.5 ENSMUST00000106251.6 ENSMUST00000106251.7 ENSMUST00000106251.8 ENSMUST00000106251.9 NM_139149 Q564D0 Q564D0_MOUSE uc009jxo.1 uc009jxo.2 uc009jxo.3 uc009jxo.4 Nucleus Belongs to the RRM TET family. nucleic acid binding chromatin binding transcription coactivator activity RNA binding nucleus nucleoplasm cytoplasm polysome regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter RNA splicing estrogen receptor binding dendrite myosin V binding ionotropic glutamate receptor binding identical protein binding neuronal cell body dendritic spine perikaryon regulation of RNA splicing dendritic spine head metal ion binding retinoid X receptor binding thyroid hormone receptor binding mRNA stabilization perinuclear region of cytoplasm protein homooligomerization cellular response to calcium ion positive regulation of nucleic acid-templated transcription positive regulation of double-strand break repair via homologous recombination uc009jxo.1 uc009jxo.2 uc009jxo.3 uc009jxo.4 
ENSMUST00000106252.9 Mycl ENSMUST00000106252.9 v-myc avian myelocytomatosis viral oncogene lung carcinoma derived, transcript variant 2 (from RefSeq NM_001303121.2) ENSMUST00000106252.1 ENSMUST00000106252.2 ENSMUST00000106252.3 ENSMUST00000106252.4 ENSMUST00000106252.5 ENSMUST00000106252.6 ENSMUST00000106252.7 ENSMUST00000106252.8 Lmyc1 Mycl Mycl1 NM_001303121 Q3UIE0 Q3UIE0_MOUSE uc290ppi.1 uc290ppi.2 This gene encodes a basic helix-loop-helix leucine zipper (bHLHZip) protein that heterodimerizes with another bHLHZip protein to drive transcription of targets important for proliferation, apoptosis and differentiation. Mice lacking this gene product show marked decrease in T-cell priming during bacterial and viral infections. In humans, this gene was found to be amplified in small-cell lung cancers. Alternate splicing of this gene results in multiple variants. [provided by RefSeq, Dec 2014]. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated protein dimerization activity uc290ppi.1 uc290ppi.2 
ENSMUST00000106257.10 Cap1 ENSMUST00000106257.10 cyclase associated actin cytoskeleton regulatory protein 1, transcript variant 3 (from RefSeq NM_001358035.1) CAP1_MOUSE Cap ENSMUST00000106257.1 ENSMUST00000106257.2 ENSMUST00000106257.3 ENSMUST00000106257.4 ENSMUST00000106257.5 ENSMUST00000106257.6 ENSMUST00000106257.7 ENSMUST00000106257.8 ENSMUST00000106257.9 NM_001358035 P40124 Q8BPT7 uc008uol.1 uc008uol.2 uc008uol.3 uc008uol.4 uc008uol.5 The product of this gene plays a role in regulating actin dynamics by binding actin monomers and promoting the turnover of actin filaments. Reduced expression of this gene causes a reduction in actin filament turnover rates, causing multiple defects, including an increase in cell size, stress-fiber alterations, and defects in endocytosis and cell motility. A pseudogene of this gene is found on chromosome 14. Alternative splicing results in multiple transcript variants, but does not affect the protein. [provided by RefSeq, Jul 2014]. Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. Homodimer. Binds actin monomers (By similarity). P40124; Q99N72: Mcf2; NbExp=3; IntAct=EBI-641927, EBI-641874; Cell membrane ; Peripheral membrane protein Ubiquitous. Belongs to the CAP family. cell morphogenesis ameboidal-type cell migration actin binding protein binding extracellular region extracellular space cytoplasm cytosol plasma membrane receptor-mediated endocytosis cytoskeleton organization establishment or maintenance of cell polarity actin polymerization or depolymerization adenylate cyclase binding membrane actin cytoskeleton organization cortical actin cytoskeleton uc008uol.1 uc008uol.2 uc008uol.3 uc008uol.4 uc008uol.5 
ENSMUST00000106259.9 Gaa ENSMUST00000106259.9 glucosidase, alpha, acid, transcript variant 1 (from RefSeq NM_008064.4) ENSMUST00000106259.1 ENSMUST00000106259.2 ENSMUST00000106259.3 ENSMUST00000106259.4 ENSMUST00000106259.5 ENSMUST00000106259.6 ENSMUST00000106259.7 ENSMUST00000106259.8 LYAG_MOUSE NM_008064 P70699 Q3UJB2 Q8BGI6 Q91Z45 uc007mqi.1 uc007mqi.2 uc007mqi.3 uc007mqi.4 uc007mqi.5 This gene encodes a lysosomal acid glucosidase that is involved in the degradation of glycogen. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that cleaves alpha-1-4 and alpha-1-6 glycosidic bonds of glycogen, maltose and intermediate oligosaccharides within the lysosome. Mice lacking the encoded protein exhibit symptoms similar to human Pompe syndrome such as accumulation of glycogen in cardiac and skeletal muscle lysosomes resulting in reduced mobility and strength. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015]. Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans. Reaction=Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D- glucose residues with release of alpha-D-glucose.; EC=3.2.1.20; Evidence=; Lysosome Lysosome membrane Belongs to the glycosyl hydrolase 31 family. maltose metabolic process regulation of the force of heart contraction diaphragm contraction heart morphogenesis catalytic activity hydrolase activity, hydrolyzing O-glycosyl compounds alpha-1,4-glucosidase activity lysosome lysosomal membrane carbohydrate metabolic process glycogen metabolic process glycogen catabolic process striated muscle contraction lysosome organization locomotory behavior metabolic process tissue development membrane hydrolase activity hydrolase activity, acting on glycosyl bonds carbohydrate binding maltose alpha-glucosidase activity vacuolar sequestering muscle cell cellular homeostasis neuromuscular process controlling posture neuromuscular process controlling balance cardiac muscle contraction alpha-glucosidase activity uc007mqi.1 uc007mqi.2 uc007mqi.3 uc007mqi.4 uc007mqi.5 
ENSMUST00000106265.3 Gm12887 ENSMUST00000106265.3 predicted gene 12887 (from RefSeq NM_001099309.1) B1AVM1 B1AVM1_MOUSE ENSMUST00000106265.1 ENSMUST00000106265.2 Gm12887 NM_001099309 uc008uoe.1 uc008uoe.2 uc008uoe.3 lysosome uc008uoe.1 uc008uoe.2 uc008uoe.3 
ENSMUST00000106266.2 Gm12886 ENSMUST00000106266.2 predicted gene 12886 (from RefSeq NM_001144948.1) B1AZM5 B1AZM5_MOUSE ENSMUST00000106266.1 Gm12886 NM_001144948 uc012dkp.1 uc012dkp.2 lysosome uc012dkp.1 uc012dkp.2 
ENSMUST00000106267.5 Stx1b ENSMUST00000106267.5 syntaxin 1B (from RefSeq NM_024414.2) A2RSB4 ENSMUST00000106267.1 ENSMUST00000106267.2 ENSMUST00000106267.3 ENSMUST00000106267.4 NM_024414 O35525 P32853 P61264 STX1B_MOUSE Stx1b1 Stx1b2 uc009jwx.1 uc009jwx.2 uc009jwx.3 Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent. Membrane ; Single-pass type IV membrane protein Phosphorylated by CK2. Belongs to the syntaxin family. SNARE binding positive regulation of neurotransmitter secretion receptor binding SNAP receptor activity protein binding nucleus nuclear lamina nucleoplasm cytoplasm centrosome plasma membrane neurotransmitter transport intracellular protein transport exocytosis vesicle docking involved in exocytosis vesicle fusion regulation of gene expression regulation of synaptic vesicle priming negative regulation of neuron projection development endomembrane system protein transport membrane integral component of membrane synaptic vesicle exocytosis synaptic vesicle docking vesicle-mediated transport regulation of exocytosis protein kinase binding protein domain specific binding axon SNARE complex neuromuscular junction synaptic vesicle fusion to presynaptic active zone membrane presynaptic membrane vesicle docking presynaptic active zone membrane calcium ion-regulated exocytosis of neurotransmitter regulation of synaptic activity spontaneous neurotransmitter secretion protein localization to membrane presynapse exocytic insertion of neurotransmitter receptor to postsynaptic membrane integral component of presynaptic membrane negative regulation of synaptic vesicle recycling positive regulation of spontaneous neurotransmitter secretion negative regulation of macropinocytosis positive regulation of excitatory postsynaptic potential uc009jwx.1 uc009jwx.2 uc009jwx.3 
ENSMUST00000106268.4 Tmco2 ENSMUST00000106268.4 transmembrane and coiled-coil domains 2 (from RefSeq NM_001081312.2) ENSMUST00000106268.1 ENSMUST00000106268.2 ENSMUST00000106268.3 J3JS82 J3JS82_MOUSE NM_001081312 Tmco2 uc008unz.1 uc008unz.2 membrane integral component of membrane uc008unz.1 uc008unz.2 
ENSMUST00000106273.3 Enpp7 ENSMUST00000106273.3 ectonucleotide pyrophosphatase/phosphodiesterase 7 (from RefSeq NM_001359574.1) A2A5N7 D3Z6V6 ENPP7_MOUSE ENSMUST00000106273.1 ENSMUST00000106273.2 Enpp7 NM_001359574 Q3TIW9 uc007mps.1 uc007mps.2 uc007mps.3 Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract (PubMed:21177474). Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation. Does not have nucleotide pyrophosphatase activity (By similarity). May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (PubMed:24650549). Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:295975; EC=3.1.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19254; Evidence=; Reaction=a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1- O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:63380, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16291, ChEBI:CHEBI:36707, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63381; Evidence=; Reaction=1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1- O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:63384, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:52450, ChEBI:CHEBI:147296, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63385; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:75542, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41120; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Cell membrane ; Single-pass type I membrane protein Note=The catalytic domain is released into the extracellular medium when cells are treated with trypsin. Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome- like structures situated beneath the microvillar membrane, and in Golgi complex. Expressed in liver and small intestine. N-glycosylated; required for activity and transport to the plasma membrane. Mutant mice are born at the expected Mendelian rate, are viable and fertile, are grown normally without obvious abnormalities. Mice shown signs of hypertrophy of the intestinal epithelium, as the widths of the villi and crypts, as well as the thickness of muscle layer under the crypts appear increased. However, no spontaneous tumorigenesis either in the small intestine or in the colon is identifiedknockout mice up to the age of 10 months. catalytic activity sphingomyelin phosphodiesterase activity Golgi apparatus integral component of plasma membrane microvillus sphingomyelin metabolic process sphingomyelin catabolic process negative regulation of DNA replication zinc ion binding negative regulation of cell proliferation dephosphorylation nucleotidase activity uc007mps.1 uc007mps.2 uc007mps.3 
ENSMUST00000106278.9 Rbfox3 ENSMUST00000106278.9 RNA binding protein, fox-1 homolog (C. elegans) 3, transcript variant 3 (from RefSeq NM_001024931.2) A2A4W7 A2A4W8 B7ZC12 B7ZC13 D11Bwg0517e D1GI07 ENSMUST00000106278.1 ENSMUST00000106278.2 ENSMUST00000106278.3 ENSMUST00000106278.4 ENSMUST00000106278.5 ENSMUST00000106278.6 ENSMUST00000106278.7 ENSMUST00000106278.8 Hrnbp3 NM_001024931 Q3TUE0 Q7TQI4 Q8BIF2 RFOX3_MOUSE uc007mpl.1 uc007mpl.2 uc007mpl.3 Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). Q8BIF2; Q61221: Hif1a; NbExp=2; IntAct=EBI-4567146, EBI-298954; Q8BIF2; Q16665: HIF1A; Xeno; NbExp=2; IntAct=EBI-4567146, EBI-447269; Nucleus. Cytoplasm. [Isoform 1]: Nucleus. [Isoform 4]: Cytoplasm. [Isoform 5]: Nucleus. Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Fox3v1, Fox-3-L; IsoId=Q8BIF2-1; Sequence=Displayed; Name=2; IsoId=Q8BIF2-2; Sequence=VSP_035220; Name=3; IsoId=Q8BIF2-3; Sequence=VSP_035219, VSP_035220; Name=4; Synonyms=Fox3v3; IsoId=Q8BIF2-4; Sequence=VSP_043949, VSP_035220; Name=5; Synonyms=Fox3v2, Fox-3-S; IsoId=Q8BIF2-5; Sequence=VSP_043949; Widely expressed in brain, including in cerebral cortex, hippocampus, thalamus, caudate/putamen, cerebellum, as well as in the spinal cord (at protein level). Not expressed in all neuronal cells within a region, in cerebellum, expression is absent in Purkinje cells (at protein level). Expressed in the retina in the ganglion cells and some cells in the inner nuclear layer, but absent from the photoreceptor cells and most cells in the inner nuclear layer (at protein level). In the neural tube, expressed as early as 9.5 dpc and expression is confined to the nervous system. By 12.5 dpc, can be found in the developing ventral horns and is also detected in the developing dorsal horns as well as in the dorsal root ganglion. Not detected in the ventricular zone, roof plate, floor plate or marginal zone (developing white matter). It is expressed from embryonic stage to adulthood. By retinoic acid. Expression is up-regulated in P19 cells during neural differentiation upon retinoic acid treatment (at the protein level). Phosphorylated. Knockout mice have significantly reduced brain weight, impaired neurofilament expression and decreased white matter volume, but normal total body mass. They show increased susceptibility to seizures and reduced anxiety-related behaviors compared with wild type littermates, as well as defective hippocampal gene expression and deficits in synaptic transmission and plasticity in the dentate gyrus. Initial characterization was derived from usage of a monoclonal antibody (A60) directed to an unknown protein called NeuN (PubMed:15605376, PubMed:1483388), but later identified as RBFOX3. regulation of alternative mRNA splicing, via spliceosome nucleic acid binding DNA binding RNA binding mRNA binding protein binding nucleus cytoplasm mRNA processing nervous system development RNA splicing neuronal cell body perikaryon regulation of RNA splicing uc007mpl.1 uc007mpl.2 uc007mpl.3 
ENSMUST00000106280.8 Zfp69 ENSMUST00000106280.8 zinc finger protein 69, transcript variant 2 (from RefSeq NM_001384119.1) A2A761 ENSMUST00000106280.1 ENSMUST00000106280.2 ENSMUST00000106280.3 ENSMUST00000106280.4 ENSMUST00000106280.5 ENSMUST00000106280.6 ENSMUST00000106280.7 NM_001384119 ZFP69_MOUSE Zfp69 Znf642 uc008unv.1 uc008unv.2 uc008unv.3 uc008unv.4 Putative transcription factor that appears to regulate lipid metabolism. Nucleus New Zealand obese (NZO) mice carry a loss-of-function mutation due to the integration of the retrotransposon IAPLTR1 in intron 3 which generates a truncated mRNA lacking both the KRAB and the C2H2 domains. This strain is less diabetes prone (NZO). Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated lipid metabolic process regulation of lipid metabolic process sequence-specific DNA binding metal ion binding uc008unv.1 uc008unv.2 uc008unv.3 uc008unv.4 
ENSMUST00000106292.8 Prr14 ENSMUST00000106292.8 proline rich 14, transcript variant 2 (from RefSeq NM_001416090.1) ENSMUST00000106292.1 ENSMUST00000106292.2 ENSMUST00000106292.3 ENSMUST00000106292.4 ENSMUST00000106292.5 ENSMUST00000106292.6 ENSMUST00000106292.7 NM_001416090 PRR14_MOUSE Q7TPN9 Q922N8 uc009jvo.1 uc009jvo.2 uc009jvo.3 Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (By similarity). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (By similarity). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157) (By similarity). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (By similarity). Interacts (via proline-rich region) with GRB2 (via SH3 domain 2). Interacts (via N-terminus) with CBX5. Chromosome Nucleus Nucleus lamina Nucleus, nucleoplasm Note=During interphase, associated with peripheral heterochromatin at the nuclear lamina. Released from the nuclear lamina in mitotic prophase and remains highly dispersed in metaphase. Associates with chromatin at the onset of anaphase and relocalizes to the nuclear lamina in telophase. Expressed in skeletal myocytes with increasing expression during differentiation and in the gastrocnemius skeletal muscle in newborn and at higher levels in 10 days old mice (at protein level). Sequence=AAH06909.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence=; molecular_function cellular_component nucleus nuclear lamina nucleoplasm chromosome muscle organ development biological_process uc009jvo.1 uc009jvo.2 uc009jvo.3 
ENSMUST00000106300.2 Zfp688 ENSMUST00000106300.2 zinc finger protein 688 (from RefSeq NM_026999.4) E9Q5M9 E9Q5M9_MOUSE ENSMUST00000106300.1 NM_026999 Zfp688 uc012fuh.1 uc012fuh.2 uc012fuh.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc012fuh.1 uc012fuh.2 uc012fuh.3 
ENSMUST00000106306.9 Itgal ENSMUST00000106306.9 integrin alpha L, transcript variant 4 (from RefSeq NM_001253874.1) E9Q5M7 E9QNL8 ENSMUST00000106306.1 ENSMUST00000106306.2 ENSMUST00000106306.3 ENSMUST00000106306.4 ENSMUST00000106306.5 ENSMUST00000106306.6 ENSMUST00000106306.7 ENSMUST00000106306.8 ITAL_MOUSE Itgal Lfa-1 Ly-15 NM_001253874 P24063 Q3U159 uc009jvb.1 uc009jvb.2 uc009jvb.3 uc009jvb.4 Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4 (PubMed:2051027). Integrin ITGAL/ITGB2 is a receptor for F11R (By similarity). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:16234355, PubMed:24158516). Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis (PubMed:25108025). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. Heterodimer of an alpha and a beta subunit. The ITGAL alpha subunit associates with the ITGB2 beta subunit. Interacts with THBD. Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P24063-1; Sequence=Displayed; Name=2; IsoId=P24063-2; Sequence=VSP_061239; Leukocytes. The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. The I-domain is necessary and sufficient for interaction with ICAM1 and F11R. In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for the activation by some physiological agents. Mice show decreased cellularity in thymus but not spleen, and impaired early T cell development (PubMed:25108025). Obese mutant mice show decreased total number of T-cells, lower levels of neutrophil elastase and reduced cytotoxic T-cell proliferation in adipose tissue, as well as improved glucose tolerance and insulin resistance in comparison to obese wild type mice (PubMed:24158516). Splenocytes from mutant mice do not respond to extracellular Isg15 as demonstrated by lack of Ifng secretion in contrast to wild-type cells which secrete Ifng in response to treatment with Isg15 (PubMed:29100055). Belongs to the integrin alpha chain family. Sequence=AAA39426.1; Type=Frameshift; Evidence=; immunological synapse T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell plasma membrane cell-cell junction phagocytosis cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion cell-matrix adhesion cell surface receptor signaling pathway integrin-mediated signaling pathway integrin complex external side of plasma membrane cell surface membrane integral component of membrane regulation of cell-cell adhesion positive regulation of cell-cell adhesion ICAM-3 receptor activity integrin alphaL-beta2 complex memory T cell extravasation positive regulation of T cell proliferation receptor clustering macromolecular complex binding metal ion binding protein heterodimerization activity activated T cell proliferation cell adhesion molecule binding positive regulation of calcium-mediated signaling cell-cell adhesion uc009jvb.1 uc009jvb.2 uc009jvb.3 uc009jvb.4 
ENSMUST00000106307.9 Hivep3 ENSMUST00000106307.9 human immunodeficiency virus type I enhancer binding protein 3 (from RefSeq NM_010657.3) A2A884 A2MZW0 ENSMUST00000106307.1 ENSMUST00000106307.2 ENSMUST00000106307.3 ENSMUST00000106307.4 ENSMUST00000106307.5 ENSMUST00000106307.6 ENSMUST00000106307.7 ENSMUST00000106307.8 KBP1 Kiaa1555 Krc NM_010657 Q69ZG6 Q6SNP9 Rc ZEP3_MOUSE Zas3 shn3 uc008una.1 uc008una.2 uc008una.3 Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B- mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. Interacts with TRAF1 and TRAF2 as well as with JUN. Forms a multimeric complex with RUNX2 and E3 ubiquitin ligase WWP1. Cytoplasm Nucleus Expressed in macrophages, lymphocytes, brain, thymus, spleen and bone marrow. Expressed in osteoblasts, whole bone and, to a lesser extent, in osteoclasts. Expressed in the thymus with increasing level, approximately 4-fold, from 15.5 dpc to 16.5 dpc, constant level from 16.5 dpc to birth, then decrease to a low level by P30. Expressed at 13.5 dpc in the dorsal root ganglia of the peripheral nervous system and the trigeminal ganglion of the metencephalon and at relatively low levels in the cerebral cortex; no significant expression was observed prior to 13.5 dpc. Expressed in the spinal cord at 19 dpc, but weakly detected in the lung and the liver. Upon CD3/CD28 stimulation in CD4 T-cells. Induced by LPS in pre-B-cells. ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordered DNA-protein structures. Phosphorylated on threonine and serine residues. Phosphorylation by cyclin-dependent kinase CDK1 decreases HIVEP3 DNA binding affinity, and by epidermal growth factor receptor kinase increases its DNA binding affinity. Mice display adult-onset osteosclerosis with increased bone mass due to increased osteoblast activity; the osteoblasts contain elevated levels of Runx2. Hivep3 gene expression is probably controlled by a combination of differential promoter usage, alternative splicing, and possible intergenic splicing. Sequence=AAA40039.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAA40039.1; Type=Frameshift; Evidence=; Sequence=AAR88090.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding nucleus cytoplasm cytosol skeletal muscle cell differentiation positive regulation of transcription, DNA-templated metal ion binding uc008una.1 uc008una.2 uc008una.3 
ENSMUST00000106312.4 Zfp553 ENSMUST00000106312.4 zinc finger protein 553, transcript variant 1 (from RefSeq NM_146201.2) ENSMUST00000106312.1 ENSMUST00000106312.2 ENSMUST00000106312.3 NM_146201 Q3UFP3 Q3US17 Q8R0V0 Q921H7 ZNF48_MOUSE Zfp48 Znf48 Znf553 uc009jut.1 uc009jut.2 uc009jut.3 uc009jut.4 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAH12403.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding nucleus biological_process metal ion binding uc009jut.1 uc009jut.2 uc009jut.3 uc009jut.4 
ENSMUST00000106314.8 Septin1 ENSMUST00000106314.8 septin 1 (from RefSeq NM_017461.3) B2RU74 Diff6 ENSMUST00000106314.1 ENSMUST00000106314.2 ENSMUST00000106314.3 ENSMUST00000106314.4 ENSMUST00000106314.5 ENSMUST00000106314.6 ENSMUST00000106314.7 NM_017461 P42209 Pnutl3 SEPT1_MOUSE Sept1 Septin1 uc009juq.1 uc009juq.2 uc009juq.3 Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with AURKB (By similarity). Cytoplasm Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody Note=Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis (By similarity). Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. Sequence=AAA37803.1; Type=Frameshift; Evidence=; nucleotide binding GTPase activity GTP binding cytoplasm microtubule organizing center cytoskeleton septin ring cell cycle spindle assembly involved in female meiosis synaptic vesicle microtubule cytoskeleton regulation of exocytosis midbody septin complex identical protein binding cell division meiotic metaphase plate congression cytoskeleton-dependent cytokinesis meiotic spindle uc009juq.1 uc009juq.2 uc009juq.3 
ENSMUST00000106318.8 Ppih ENSMUST00000106318.8 peptidyl prolyl isomerase H, transcript variant 1 (from RefSeq NM_028677.4) ENSMUST00000106318.1 ENSMUST00000106318.2 ENSMUST00000106318.3 ENSMUST00000106318.4 ENSMUST00000106318.5 ENSMUST00000106318.6 ENSMUST00000106318.7 NM_028677 PPIH_MOUSE Q9CQU7 Q9D868 uc008ulx.1 uc008ulx.2 uc008ulx.3 uc008ulx.4 PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Inhibited by cyclosporin A. Interacts directly with PRPF4. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Heterodimer with PRPF18. Heterodimer with PRPF18 (By similarity). Nucleus speckle Cytoplasm Note=Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D868-1; Sequence=Displayed; Name=2; IsoId=Q9D868-2; Sequence=VSP_008325; Belongs to the cyclophilin-type PPIase family. PPIase H subfamily. protein peptidyl-prolyl isomerization angiogenesis peptidyl-prolyl cis-trans isomerase activity nucleus spliceosomal complex cytoplasm mRNA processing protein folding RNA splicing cyclosporin A binding nuclear speck isomerase activity protein refolding ribonucleoprotein complex binding positive regulation of viral genome replication U4/U6 x U5 tri-snRNP complex unfolded protein binding U4/U6 snRNP uc008ulx.1 uc008ulx.2 uc008ulx.3 uc008ulx.4 
ENSMUST00000106331.2 6030468B19Rik ENSMUST00000106331.2 RIKEN cDNA 6030468B19 gene (from RefSeq NM_029964.1) B1ATC1 ENSMUST00000106331.1 IL40_MOUSE NM_029964 Q9CX63 uc007mnv.1 uc007mnv.2 uc007mnv.3 uc007mnv.4 Probable B cell-associated cytokine that plays a role in the regulation of humoral immune responses (PubMed:28978694). Involved in lymphocyte B cell development and immunoglobulin/IgA production (PubMed:28978694). Secreted Expressed in bone marrow, spleen and lymph node (PubMed:28978694). Up-regulated in the mammary gland upon the onset of lactation (PubMed:28978694). Up-regulated in peripheral blood lymphocyte B cells upon activation (PubMed:28978694). Mice are viable and reproduce normally (PubMed:28978694). Show reduced number of both peripheral lymphocyte B cells in the spleen and precursor and mature lymphocyte B cells in the bone marrow (PubMed:28978694). Show smaller and fewer Peyer's patches, lower numbers of immunoglobulin/IgA-secreting B cells and an altered gut microbiome (PubMed:28978694). Exhibit reduced levels of immunoglobulin/IgA in the serum, gut, feces, and lactating mammary gland (PubMed:28978694). adaptive immune response mature B cell differentiation involved in immune response immune system process molecular_function cytokine activity extracellular region extracellular space signal transduction positive regulation of immunoglobulin production in mucosal tissue uc007mnv.1 uc007mnv.2 uc007mnv.3 uc007mnv.4 
ENSMUST00000106333.8 Sez6l2 ENSMUST00000106333.8 seizure related 6 homolog like 2, transcript variant 1 (from RefSeq NM_144926.5) ENSMUST00000106333.1 ENSMUST00000106333.2 ENSMUST00000106333.3 ENSMUST00000106333.4 ENSMUST00000106333.5 ENSMUST00000106333.6 ENSMUST00000106333.7 NM_144926 Q4V9Z5 Q6AXF9 Q91X64 SE6L2_MOUSE uc009jtq.1 uc009jtq.2 uc009jtq.3 uc009jtq.4 May contribute to specialized endoplasmic reticulum functions in neurons. Cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Note=In cerebellar predominantly localized to the endoplasmic reticulum. Event=Alternative splicing; Named isoforms=3; Comment=Named isoforms=3.; Name=1; IsoId=Q4V9Z5-1; Sequence=Displayed; Name=2; IsoId=Q4V9Z5-2; Sequence=VSP_033599; Name=3; IsoId=Q4V9Z5-3; Sequence=VSP_033598, VSP_033599; Expressed exclusively in the brain, predominantly in the neurons. Wide expression in the gray matter of the brain with high levels in the olfactory bulb, anterior olfactory nuclei, hippocampal formation and cerebellar cortex. Detected diffusely and weakly in the white matter, such as the corpus callosum and cerebellar medulla. In the cerebellar cortex, intensely expressed in Purkinje cells (PC) and granule cells. Detected also in interneurons in the molecular layer. Up-regulated at two weeks after birth. Mice lacking Sez6, Sez6l1, Sez6l2 exhibit motor discordination, and PCs are ofen innervated by multiple climbing fibers with different neuronal origins in the cerebellum. Belongs to the SEZ6 family. endoplasmic reticulum endoplasmic reticulum membrane plasma membrane adult locomotory behavior membrane integral component of membrane cerebellar Purkinje cell layer development neuronal cell body synapse maturation regulation of protein kinase C signaling uc009jtq.1 uc009jtq.2 uc009jtq.3 uc009jtq.4 
ENSMUST00000106334.9 Tmc8 ENSMUST00000106334.9 transmembrane channel-like gene family 8, transcript variant B (from RefSeq NM_001195089.1) ENSMUST00000106334.1 ENSMUST00000106334.2 ENSMUST00000106334.3 ENSMUST00000106334.4 ENSMUST00000106334.5 ENSMUST00000106334.6 ENSMUST00000106334.7 ENSMUST00000106334.8 Ever2 NM_001195089 Q3TAL0 Q3UWI0 Q7TN58 Q7TQ67 TMC8_MOUSE uc007mnt.1 uc007mnt.2 uc007mnt.3 uc007mnt.4 Probable ion channel. Interacts with CIB1. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TN58-1; Sequence=Displayed; Name=2; IsoId=Q7TN58-2; Sequence=VSP_016451; Expressed in thymus, lung, prostate, placenta, testis and spleen. Belongs to the TMC family. regulation of cell growth receptor binding ion channel activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus integral component of plasma membrane ion transport mechanically-gated ion channel activity membrane integral component of membrane nuclear membrane negative regulation of protein binding negative regulation of protein oligomerization ion transmembrane transport zinc ion homeostasis transmembrane transport regulation of extrinsic apoptotic signaling pathway via death domain receptors uc007mnt.1 uc007mnt.2 uc007mnt.3 uc007mnt.4 
ENSMUST00000106337.7 Cyp2u1 ENSMUST00000106337.7 cytochrome P450, family 2, subfamily u, polypeptide 1 (from RefSeq NM_027816.3) CP2U1_MOUSE Cyp2u1 ENSMUST00000106337.1 ENSMUST00000106337.2 ENSMUST00000106337.3 ENSMUST00000106337.4 ENSMUST00000106337.5 ENSMUST00000106337.6 NM_027816 Q8BIM3 Q9CX98 uc008rjn.1 uc008rjn.2 uc008rjn.3 A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N- arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin. Reaction=an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH-- hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:56748, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:140991, ChEBI:CHEBI:140992; EC=1.14.14.80; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56749; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39759, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76627; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39760; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39755, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76624; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39756; Evidence=; Reaction=N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] = 2-oxo-N-[(5Z,8Z,11Z,14Z)- eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase]; Xref=Rhea:RHEA:50296, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132255, ChEBI:CHEBI:132256; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50297; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Microsome membrane ; Multi-pass membrane protein Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9CX98-1; Sequence=Displayed; Name=2; IsoId=Q9CX98-2; Sequence=VSP_026227, VSP_026228; Name=3; IsoId=Q9CX98-3; Sequence=VSP_026224, VSP_026225, VSP_026226; Widely expressed. Expressed in heart, brain and liver. Expressed at all stages after 7 dpc. Expressed in brain structures including cortex, diencephalon, medulla oblongata, spine and cerebellum at 12 dpc. Expression in embryonic nervous system increases during development, as measured at 15 dpc and 18 dpc timepoints. Belongs to the cytochrome P450 family. Sequence=AK142740; Type=Frameshift; Evidence=; monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding organelle membrane exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc008rjn.1 uc008rjn.2 uc008rjn.3 
ENSMUST00000106340.8 Asphd1 ENSMUST00000106340.8 aspartate beta-hydroxylase domain containing 1, transcript variant 1 (from RefSeq NM_001347657.2) ASPH1_MOUSE ENSMUST00000106340.1 ENSMUST00000106340.2 ENSMUST00000106340.3 ENSMUST00000106340.4 ENSMUST00000106340.5 ENSMUST00000106340.6 ENSMUST00000106340.7 NM_001347657 Q2TA57 uc009jtn.1 uc009jtn.2 uc009jtn.3 uc009jtn.4 Membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2TA57-1; Sequence=Displayed; Name=2; IsoId=Q2TA57-2; Sequence=VSP_039171; Belongs to the aspartyl/asparaginyl beta-hydroxylase family. molecular_function cellular_component biological_process membrane integral component of membrane oxidoreductase activity peptidyl-amino acid modification dioxygenase activity oxidation-reduction process uc009jtn.1 uc009jtn.2 uc009jtn.3 uc009jtn.4 
ENSMUST00000106343.3 Ino80e ENSMUST00000106343.3 Ino80e (from geneSymbol) AK135531 D3Z3H0 D3Z3H0_MOUSE ENSMUST00000106343.1 ENSMUST00000106343.2 Ino80e uc009jtd.1 uc009jtd.2 uc009jtd.3 molecular_function nucleus nucleolus chromatin remodeling biological_process Ino80 complex uc009jtd.1 uc009jtd.2 uc009jtd.3 
ENSMUST00000106348.8 Aldoa ENSMUST00000106348.8 aldolase A, fructose-bisphosphate, transcript variant 3 (from RefSeq NM_001177308.2) Aldoa ENSMUST00000106348.1 ENSMUST00000106348.2 ENSMUST00000106348.3 ENSMUST00000106348.4 ENSMUST00000106348.5 ENSMUST00000106348.6 ENSMUST00000106348.7 NM_001177308 Q5FWB7 Q5FWB7_MOUSE uc009jsv.1 uc009jsv.2 uc009jsv.3 uc009jsv.4 Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3- phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729, ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=4.1.2.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14730; Evidence=; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 4/4. Cytoplasm, myofibril, sarcomere, I band Cytoplasm, myofibril, sarcomere, M line Belongs to the class I fructose-bisphosphate aldolase family. catalytic activity fructose-bisphosphate aldolase activity glycolytic process lyase activity uc009jsv.1 uc009jsv.2 uc009jsv.3 uc009jsv.4 
ENSMUST00000106355.5 Zfp691 ENSMUST00000106355.5 zinc finger protein 691, transcript variant 3 (from RefSeq NM_001145936.1) A2A7P4 A2A7P4_MOUSE ENSMUST00000106355.1 ENSMUST00000106355.2 ENSMUST00000106355.3 ENSMUST00000106355.4 NM_001145936 Zfp691 uc008ulg.1 uc008ulg.2 uc008ulg.3 uc008ulg.4 uc008ulg.5 Nucleus nucleic acid binding uc008ulg.1 uc008ulg.2 uc008ulg.3 uc008ulg.4 uc008ulg.5 
ENSMUST00000106361.3 Or10ak16 ENSMUST00000106361.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEY6) B1ARU7 B1ARU8 E9Q234 ENSMUST00000106361.1 ENSMUST00000106361.2 Olfr1330 Olfr1331 Olfr1333 Olfr1335 Or10ak16 Q8VEY6 Q8VEY6_MOUSE uc290piy.1 uc290piy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc290piy.1 uc290piy.2 
ENSMUST00000106370.10 Mettl23 ENSMUST00000106370.10 methyltransferase like 23 (from RefSeq NM_028865.3) A2AA28 ENSMUST00000106370.1 ENSMUST00000106370.2 ENSMUST00000106370.3 ENSMUST00000106370.4 ENSMUST00000106370.5 ENSMUST00000106370.6 ENSMUST00000106370.7 ENSMUST00000106370.8 ENSMUST00000106370.9 MET23_MOUSE Mettl23 NM_028865 Q8R2Z2 Q9D1J5 uc007mml.1 uc007mml.2 uc007mml.3 uc007mml.4 Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (PubMed:28930672). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (PubMed:28930672). Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA- COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48097; Evidence=; Interacts with HSPA5, HSP90B1, TUBULIN, UGGT1 and UGGT2 (By similarity). Interacts with TET3 (PubMed:28930672). Interacts with STPG4 (PubMed:28930672). Nucleus Cytoplasm Note=Localizes in male and female zygote pronucleus and cytoplasm. Ubiquitously expressed. Mice give birth to significantly smaller litter sizes (PubMed:28930672). Moreover, about a third of the homozygous newborn mice die before weaning and only a few survive to adulthood (PubMed:28930672). Strongly reduced 5-hydroxymethylcytosine (5hmC) levels in zygotes (PubMed:28930672). Belongs to the methyltransferase superfamily. METTL23 family. Sequence=AAH26936.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB22797.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleus cytoplasm transcription factor binding methyltransferase activity membrane integral component of membrane transferase activity heat shock protein binding methylation macromolecular complex positive regulation of transcription from RNA polymerase II promoter cognition uc007mml.1 uc007mml.2 uc007mml.3 uc007mml.4 
ENSMUST00000106373.9 Sult1a1 ENSMUST00000106373.9 sulfotransferase family 1A, phenol-preferring, member 1, transcript variant 1 (from RefSeq NM_133670.3) E9QNL5 E9QNL5_MOUSE ENSMUST00000106373.1 ENSMUST00000106373.2 ENSMUST00000106373.3 ENSMUST00000106373.4 ENSMUST00000106373.5 ENSMUST00000106373.6 ENSMUST00000106373.7 ENSMUST00000106373.8 NM_133670 Sult1a1 uc009jsf.1 uc009jsf.2 uc009jsf.3 Homodimer. Belongs to the sulfotransferase 1 family. sulfotransferase activity transferase activity uc009jsf.1 uc009jsf.2 uc009jsf.3 
ENSMUST00000106382.11 Pitx2 ENSMUST00000106382.11 paired-like homeodomain transcription factor 2, transcript variant 1 (from RefSeq NM_001042504.2) Arp1 Brx1 ENSMUST00000106382.1 ENSMUST00000106382.10 ENSMUST00000106382.2 ENSMUST00000106382.3 ENSMUST00000106382.4 ENSMUST00000106382.5 ENSMUST00000106382.6 ENSMUST00000106382.7 ENSMUST00000106382.8 ENSMUST00000106382.9 NM_001042504 O08646 O70336 Otlx2 P97474 P97933 PITX2_MOUSE Pitx2 Ptx2 Q9JLA0 Q9QXB8 Q9R1V9 Q9Z141 Rgs uc008rhv.1 uc008rhv.2 uc008rhv.3 uc008rhv.4 Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform Ptx2c is involved in left-right asymmetry the developing embryo. Interacts with PITX2. P97474; Q60795: Nfe2l2; NbExp=2; IntAct=EBI-1175125, EBI-642563; P97474; P46938: Yap1; NbExp=2; IntAct=EBI-1175125, EBI-1211949; Nucleus. Event=Alternative splicing, Alternative initiation; Named isoforms=5; Name=Ptx2B; Synonyms=ARP1B, BRX1B; IsoId=P97474-1; Sequence=Displayed; Name=Ptx2C; Synonyms=ARP1C, BRX1A; IsoId=P97474-2; Sequence=VSP_002262; Name=Ptx2A; Synonyms=ARP1A; IsoId=P97474-3; Sequence=VSP_002263; Name=Pitx2Calpha; IsoId=P97474-4; Sequence=VSP_031522; Name=Pitx2Cbeta; IsoId=P97474-5; Sequence=VSP_031521; In day-11 embryos, expressed in the periocular mesenchyme, maxillary and mandibular epithelia, umbilicus, Rathke pouch, vitelline vessels and limb mesenchyme. In adult tissues, expressed in pituitary gland, brain, kidney, eye, lung, testis and tongue. Expressed in the embryonic heart. Expressed in the left lateral plate mesoderm and symmetrically in the head mesoderm at 8.5 dpc. Isoform Ptx2c is expressed in the ventral outflow tract region (OFT), right ventricle (RV) and in the left atrium of the heart. Phosphorylation at Thr-90 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. Mice embryos lacking isoform Ptx2c show left- right patterning defects and severe developmental abnormalities. [Isoform Pitx2Cbeta]: Produced by alternative initiation at Met-35 of isoform Ptx2C. Belongs to the paired homeobox family. Bicoid subfamily. Sequence=AAF44618.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding branching involved in blood vessel morphogenesis vasculogenesis in utero embryonic development neuron migration extraocular skeletal muscle development atrioventricular valve development cardiac neural crest cell migration involved in outflow tract morphogenesis pulmonary myocardium development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development determination of left/right symmetry brain development heart development skeletal muscle tissue development myoblast fusion transcription factor binding male gonad development female gonad development anatomical structure morphogenesis response to hormone animal organ morphogenesis Wnt signaling pathway subthalamic nucleus development hypothalamus cell migration pituitary gland development neuron differentiation lung development regulation of cell migration embryonic camera-type eye development chromatin DNA binding response to vitamin A embryonic hindlimb morphogenesis vascular smooth muscle cell differentiation deltoid tuberosity development regulation of cell proliferation odontogenesis of dentin-containing tooth odontogenesis identical protein binding protein homodimerization activity camera-type eye development positive regulation of DNA binding sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter spleen development embryonic digestive tract morphogenesis cardiac muscle tissue development phosphoprotein binding cardiac muscle cell differentiation atrial cardiac muscle tissue morphogenesis ventricular cardiac muscle cell development digestive system development ventricular septum morphogenesis left lung morphogenesis pulmonary vein morphogenesis superior vena cava morphogenesis endodermal digestive tract morphogenesis iris morphogenesis cell proliferation involved in outflow tract morphogenesis left/right axis specification positive regulation of myoblast proliferation uc008rhv.1 uc008rhv.2 uc008rhv.3 uc008rhv.4 
ENSMUST00000106388.9 Sphk1 ENSMUST00000106388.9 sphingosine kinase 1, transcript variant 6 (from RefSeq NM_001372484.1) ENSMUST00000106388.1 ENSMUST00000106388.2 ENSMUST00000106388.3 ENSMUST00000106388.4 ENSMUST00000106388.5 ENSMUST00000106388.6 ENSMUST00000106388.7 ENSMUST00000106388.8 NM_001372484 O88886 Q3U2E3 Q8CI15 Q91ZN3 SPHK1_MOUSE Sk1 Sphk1 uc288dte.1 uc288dte.2 This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.2716910.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions (PubMed:17346996, PubMed:21084291, PubMed:25417698, PubMed:29662056, PubMed:33334894). Also acts on D- erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol (PubMed:9726979). In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis (PubMed:16118219). Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling (By similarity). In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway (By similarity). Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity (PubMed:27806293, PubMed:28049734). In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA (PubMed:25417698). Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner. The acetyltransferase activity increases in presence of the kinase substrate, sphingosine. During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15- R-lipoxin A4, which results in an increase of phagocytic microglia. Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+); Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216; EC=2.7.1.91; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51497; Evidence= Reaction=acetyl-CoA + L-seryl-[protein] = CoA + O-acetyl-L-seryl- [protein]; Xref=Rhea:RHEA:59392, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:15352, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:141128; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59393; Evidence=; Reaction=ATP + sphinganine = ADP + H(+) + sphinganine 1-phosphate; Xref=Rhea:RHEA:15465, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57817, ChEBI:CHEBI:57939, ChEBI:CHEBI:456216; EC=2.7.1.91; Evidence=; Reaction=ATP + sphing-4-enine = ADP + H(+) + sphing-4-enine 1- phosphate; Xref=Rhea:RHEA:35847, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119, ChEBI:CHEBI:456216; EC=2.7.1.91; Evidence=; Reaction=1-O-hexadecyl-2-amino-sn-glycerol + ATP = 1-O-hexadecyl-2- desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:41163, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77786, ChEBI:CHEBI:77787, ChEBI:CHEBI:456216; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Acetyltransferase activity increases in presence of the kinase substrate, sphingosine (PubMed:29662056). In Purkinje cells, kinase activity on sphingosine increases in presence of VEGFA (PubMed:25417698). In neurons, kinase activity increases during the first 24h in presence of Amyloid-beta protein 42 to decrease after 96h (By similarity). Kinetic parameters: KM=60.2 uM for Acetyl-CoA (in presence of 10 uM of sphingosine) ; KM=6.4 uM for Acetyl-CoA (in presence of 100 uM of sphingosine) ; Note=kcat is 0.0185 min(-1) for Acetyl-CoA as substrate. ; Interacts with ACY1 (PubMed:15196915). Binds to calmodulin. Interacts with SPHKAP (By similarity). Interacts with CIB1, the interaction occurs in a calcium-dependent manner (By similarity). Interacts with TRAF2 (By similarity). Interacts with EEF1A1; the interaction enhances SPHK1 kinase activity (By similarity). Cytoplasm dosome membrane ; Peripheral membrane protein Nucleus Cell membrane Synapse Note=Translocated from the cytoplasm to the plasma membrane in a CIB1- dependent manner. Binds to membranes containing negatively charged lipids but not neutral lipids (By similarity). Recruited to endocytic membranes by sphingosine where promotes membrane fusion (PubMed:27806293). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CI15-1; Sequence=Displayed; Name=2; IsoId=Q8CI15-2; Sequence=VSP_033448; Name=3; IsoId=Q8CI15-3; Sequence=VSP_033449; Widely expressed (PubMed:9726979). Expressed in brain (at protein level). Detected in neurons. At 10.5 dpc, expressed in the whole brain, with the highest levels in the telencephalon. Mutants are viable, fertile and without any obvious abnormalities (PubMed:15459201). Mutant mice show reduced SPP levels in serum (PubMed:16314531, PubMed:15459201). Conditional mutants in neurons exhibit a decrease of amyloid-beta phagocytic activity (PubMed:29662056). Double knockout for SPHK1 and SPHK2 causes embryonic lethality (PubMed:16314531). Between 11.5 dpc and 12.5 dpc embryos exhibit cranial hemorrhage and die at 13.5 dpc (PubMed:16314531). At 11.5 dpc the wall of the dorsal aorta is poorly developed and endothelial cells are severely defective in all blood vessels in the mesenchymal region of the head (PubMed:16314531). Double knockout embryos also show a neural tube deffect (PubMed:16314531). nucleotide binding magnesium ion binding blood vessel development positive regulation of protein phosphorylation positive regulation of neurotransmitter secretion sphingosine-1-phosphate signaling pathway DNA binding NAD+ kinase activity calmodulin binding ATP binding nucleus cytoplasm endosome cytosol plasma membrane clathrin-coated pit protein acetylation sphingosine metabolic process inflammatory response brain development synaptic vesicle positive regulation of cell proliferation lipid binding sphinganine kinase activity endosome membrane positive regulation of peptidyl-threonine phosphorylation regulation of tumor necrosis factor-mediated signaling pathway positive regulation of neuron projection development membrane kinase activity phosphorylation acetyltransferase activity transferase activity D-erythro-sphingosine kinase activity cyclooxygenase pathway calcium-mediated signaling cell junction regulation of endocytosis endocytic vesicle positive regulation of cell growth positive regulation of cell migration axon positive regulation of protein ubiquitination early endosome membrane regulation of interleukin-1 beta production positive regulation of interleukin-17 production response to tumor necrosis factor cellular response to vascular endothelial growth factor stimulus sphingosine-1-phosphate receptor activity neuron projection negative regulation of apoptotic process synapse positive regulation of angiogenesis positive regulation of mitotic nuclear division positive regulation of mitotic cell cycle positive regulation of smooth muscle contraction sphingosine biosynthetic process lipid phosphorylation positive regulation of fibroblast proliferation regulation of phagocytosis positive regulation of NF-kappaB transcription factor activity protein phosphatase 2A binding cellular response to hydrogen peroxide DNA biosynthetic process sphingolipid mediated signaling pathway presynapse negative regulation of ceramide biosynthetic process positive regulation of p38MAPK cascade positive regulation of NIK/NF-kappaB signaling regulation of microglial cell activation regulation of endosomal vesicle fusion uc288dte.1 uc288dte.2 
ENSMUST00000106391.8 Prpsap1 ENSMUST00000106391.8 phosphoribosyl pyrophosphate synthetase-associated protein 1, transcript variant 3 (from RefSeq NM_026364.2) B1AT82 B1AT82_MOUSE ENSMUST00000106391.1 ENSMUST00000106391.2 ENSMUST00000106391.3 ENSMUST00000106391.4 ENSMUST00000106391.5 ENSMUST00000106391.6 ENSMUST00000106391.7 NM_026364 Prpsap1 uc007mld.1 uc007mld.2 uc007mld.3 uc007mld.4 Belongs to the ribose-phosphate pyrophosphokinase family. magnesium ion binding ribose phosphate diphosphokinase activity nucleoside metabolic process nucleotide biosynthetic process identical protein binding uc007mld.1 uc007mld.2 uc007mld.3 uc007mld.4 
ENSMUST00000106402.8 Camk2d ENSMUST00000106402.8 calcium/calmodulin-dependent protein kinase II, delta, transcript variant 4 (from RefSeq NM_001293663.1) ENSMUST00000106402.1 ENSMUST00000106402.2 ENSMUST00000106402.3 ENSMUST00000106402.4 ENSMUST00000106402.5 ENSMUST00000106402.6 ENSMUST00000106402.7 KCC2D_MOUSE Kiaa4163 NM_001293663 Q3UF87 Q3UQH9 Q5DTK4 Q6PHZ2 Q8CAC5 Q9CZE2 uc008rgn.1 uc008rgn.2 uc008rgn.3 uc008rgn.4 Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport (PubMed:12676814, PubMed:15456698, PubMed:17124532). Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure (PubMed:12676814, PubMed:19381018, PubMed:19179290). Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808' (PubMed:20194790). In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction (PubMed:15793582). In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure (PubMed:17124532). Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency- dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17; Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity. CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with RRAD (By similarity). Interacts with CACNB2. Q6PHZ2; Q9JJ28: Flii; NbExp=5; IntAct=EBI-2308458, EBI-7996161; Q6PHZ2; E9Q401: Ryr2; NbExp=2; IntAct=EBI-2308458, EBI-643628; Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Delta 2; IsoId=Q6PHZ2-1; Sequence=Displayed; Name=2; Synonyms=Delta 6; IsoId=Q6PHZ2-2; Sequence=VSP_023103, VSP_023102; Name=3; Synonyms=Delta 10; IsoId=Q6PHZ2-4; Sequence=VSP_023101, VSP_023103, VSP_023102; Name=4; Synonyms=Delta 5; IsoId=Q6PHZ2-5; Sequence=VSP_023100, VSP_023103, VSP_023102; Expressed in cardiac muscle and skeletal muscle. Isoform Delta 2, isoform Delta 6, isoform Delta 6 and isoform Delta 10 are expressed in cardiac muscle. Isoform Delta 2 is expressed in skeletal muscle. The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization. Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state (By similarity). Mice overexpressing CaMK2D develop a dilated cardiomyopathy, enlarged myocytes with reduced contractility and altered Ca(2+) handling, and die prematurely in PubMed:12676814. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Sequence=BAD90304.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; G1/S transition of mitotic cell cycle nucleotide binding response to hypoxia regulation of sodium ion transport regulation of membrane depolarization protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity protein binding calmodulin binding ATP binding nucleus cytoplasm cytosol plasma membrane protein phosphorylation calcium ion transport positive regulation of cardiac muscle hypertrophy regulation of cell communication by electrical coupling positive regulation of cardiac muscle cell apoptotic process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum positive regulation of G2/M transition of mitotic cell cycle intercalated disc positive regulation of smooth muscle cell migration membrane kinase activity phosphorylation sarcoplasmic reticulum transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation sodium channel inhibitor activity cellular potassium ion homeostasis T-tubule titin binding neuromuscular junction endoplasmic reticulum calcium ion homeostasis macromolecular complex sarcoplasmic reticulum membrane positive regulation of Rac protein signal transduction sarcolemma identical protein binding protein homodimerization activity neuron projection neuronal cell body axon initial segment ion channel binding protein autophosphorylation perinuclear region of cytoplasm nitric-oxide synthase binding protein oligomerization relaxation of cardiac muscle cardiac muscle contraction regulation of cellular localization cell growth involved in cardiac muscle cell development positive regulation of ERK1 and ERK2 cascade cardiac muscle cell contraction regulation of cardiac muscle cell action potential regulation of relaxation of cardiac muscle negative regulation of sodium ion transmembrane transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel regulation of protein localization to plasma membrane positive regulation of vascular smooth muscle cell proliferation positive regulation of DNA biosynthetic process negative regulation of sodium ion transmembrane transporter activity uc008rgn.1 uc008rgn.2 uc008rgn.3 uc008rgn.4 
ENSMUST00000106405.2 Rabep2 ENSMUST00000106405.2 Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis. (from UniProt Q91WG2) BC004088 ENSMUST00000106405.1 Q3UMK8 Q91WG2 Q99KN3 RABE2_MOUSE Rabpt5b uc291vka.1 uc291vka.2 Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis. Heterodimer with RABGEF1. The dimer binds RAB5A that has been activated by GTP-binding. Interacts with SDCCAG8; this interaction is important for ciliogenesis regulation. Interacts with RAB4A; this interaction may mediate VEGFR2 cell surface expression. Cytoplasm Early endosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q91WG2-3; Sequence=Displayed; Name=2; IsoId=Q91WG2-1; Sequence=VSP_010460; Name=3; IsoId=Q91WG2-2; Sequence=VSP_010461; Belongs to the rabaptin family. GTPase activator activity cytoplasm endosome early endosome centrosome microtubule organizing center cytosol cytoskeleton endocytosis signal transduction growth factor activity protein transport cell projection organization ciliary basal body cell projection intracellular membrane-bounded organelle positive regulation of GTPase activity regulation of cilium assembly uc291vka.1 uc291vka.2 
ENSMUST00000106406.9 Kdm4a ENSMUST00000106406.9 lysine (K)-specific demethylase 4A, transcript variant 8 (from RefSeq NR_189679.1) A2A8L8 ENSMUST00000106406.1 ENSMUST00000106406.2 ENSMUST00000106406.3 ENSMUST00000106406.4 ENSMUST00000106406.5 ENSMUST00000106406.6 ENSMUST00000106406.7 ENSMUST00000106406.8 Jhdm3a Jmjd2 Jmjd2a KDM4A_MOUSE Kiaa0677 NR_189679 Q3UKM5 Q3UM81 Q3UWV2 Q6ZQ72 Q8BW72 Q8K137 uc008ujn.1 uc008ujn.2 uc008ujn.3 uc008ujn.4 Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:24953653). Does not demethylate histone H3 'Lys- 4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively (By similarity). Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)- [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60200, Rhea:RHEA- COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961; EC=1.14.11.66; Evidence=; Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)- [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- lysyl(36)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60236, Rhea:RHEA-COMP:9786, Rhea:RHEA-COMP:15536, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961; EC=1.14.11.69; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BW72-1; Sequence=Displayed; Name=2; IsoId=Q8BW72-2; Sequence=VSP_016144, VSP_016145; Widely expressed. The 2 Tudor domains recognize and bind methylated histone H3 'Lys-4' residue (H3K4me). Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails. Trimethylated H3 'Lys-4' (H3K4me3) is bound in a cage of 3 aromatic residues, 2 of which are from the Tudor domain 2, while the binding specificity is determined by side-chain interactions involving residues from the Tudor domain 1. The Tudor domains are also able to bind trimethylated histone H3 'Lys-9' (H3K9me3), di- and trimethylated H4 'Lys-20' (H4K20me2 and H4K20me3). Has high affinity for H4K20me2, blocking recruitment of proteins such as TP53BP1 (By similarity). Ubiquitinated by RNF8 and RNF168, leading to its degradation (PubMed:24953653). Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited (By similarity). Belongs to the JHDM3 histone demethylase family. Sequence=BAC97997.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; fibrillar center nucleus pericentric heterochromatin cytoplasm cytosol chromatin organization chromatin remodeling zinc ion binding negative regulation of autophagy positive regulation of gene expression negative regulation of gene expression cardiac muscle hypertrophy in response to stress oxidoreductase activity histone demethylation ubiquitin protein ligase binding response to nutrient levels histone demethylase activity histone demethylase activity (H3-K9 specific) histone H3-K9 demethylation methylated histone binding histone methyltransferase complex positive regulation of neuron differentiation negative regulation of transcription, DNA-templated metal ion binding negative regulation of astrocyte differentiation dioxygenase activity histone demethylase activity (H3-K36 specific) oxidation-reduction process negative regulation of cell death histone H3-K36 demethylation negative regulation of histone H3-K9 trimethylation uc008ujn.1 uc008ujn.2 uc008ujn.3 uc008ujn.4 
ENSMUST00000106413.10 Exoc7 ENSMUST00000106413.10 exocyst complex component 7, transcript variant 6 (from RefSeq NM_001378960.1) A2AAN0 A2AAN0_MOUSE ENSMUST00000106413.1 ENSMUST00000106413.2 ENSMUST00000106413.3 ENSMUST00000106413.4 ENSMUST00000106413.5 ENSMUST00000106413.6 ENSMUST00000106413.7 ENSMUST00000106413.8 ENSMUST00000106413.9 Exoc7 NM_001378960 uc057kmy.1 uc057kmy.2 uc057kmy.3 Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the EXO70 family. exocyst exocytosis protein transport uc057kmy.1 uc057kmy.2 uc057kmy.3 
ENSMUST00000106426.8 Synpo2 ENSMUST00000106426.8 synaptopodin 2, transcript variant 1 (from RefSeq NM_080451.2) E9Q1U2 E9Q1U2_MOUSE ENSMUST00000106426.1 ENSMUST00000106426.2 ENSMUST00000106426.3 ENSMUST00000106426.4 ENSMUST00000106426.5 ENSMUST00000106426.6 ENSMUST00000106426.7 NM_080451 Synpo2 uc012cxa.1 uc012cxa.2 uc012cxa.3 Belongs to the synaptopodin family. autophagosome assembly stress fiber nucleus cytosol focal adhesion actin cytoskeleton Z disc protein binding, bridging filamin binding intracellular membrane-bounded organelle alpha-actinin binding chaperone-mediated autophagy tethering complex uc012cxa.1 uc012cxa.2 uc012cxa.3 
ENSMUST00000106429.6 1810037I17Rik ENSMUST00000106429.6 RIKEN cDNA 1810037I17 gene (from RefSeq NM_024461.2) CD003_MOUSE ENSMUST00000106429.1 ENSMUST00000106429.2 ENSMUST00000106429.3 ENSMUST00000106429.4 ENSMUST00000106429.5 NM_024461 Q8CEY1 Q99M08 uc008rey.1 uc008rey.2 uc008rey.3 Membrane ; Single-pass membrane protein protein binding endoplasmic reticulum membrane membrane integral component of membrane negative regulation of calcium ion binding negative regulation of calcium-transporting ATPase activity uc008rey.1 uc008rey.2 uc008rey.3 
ENSMUST00000106436.8 Kif2c ENSMUST00000106436.8 kinesin family member 2C, transcript variant 2 (from RefSeq NM_001290662.1) ENSMUST00000106436.1 ENSMUST00000106436.2 ENSMUST00000106436.3 ENSMUST00000106436.4 ENSMUST00000106436.5 ENSMUST00000106436.6 ENSMUST00000106436.7 Kif2c NM_001290662 Q3TTL2 Q3TTL2_MOUSE uc290pcu.1 uc290pcu.2 Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton Nucleus Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding motor activity microtubule motor activity ATP binding microtubule microtubule-based movement microtubule binding uc290pcu.1 uc290pcu.2 
ENSMUST00000106437.2 Hs3st4 ENSMUST00000106437.2 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 (from RefSeq NM_001252072.2) D3YVV6 D3YVV6_MOUSE ENSMUST00000106437.1 Hs3st4 NM_001252072 uc029woh.1 uc029woh.2 uc029woh.3 Belongs to the sulfotransferase 1 family. cellular_component sulfotransferase activity [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity transferase activity uc029woh.1 uc029woh.2 uc029woh.3 
ENSMUST00000106439.2 Mrpl38 ENSMUST00000106439.2 mitochondrial ribosomal protein L38 (from RefSeq NM_024177.3) A2A869 ENSMUST00000106439.1 NM_024177 Q3TXY6 Q8BTZ1 Q8K2M0 Q99LM1 RM38_MOUSE uc007mkd.1 uc007mkd.2 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2M0-1; Sequence=Displayed; Name=2; IsoId=Q8K2M0-2; Sequence=VSP_021748; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily. Sequence=AAH30739.1; Type=Erroneous initiation; Evidence=; Sequence=BAE30538.1; Type=Erroneous initiation; Evidence=; Sequence=BAE34778.1; Type=Erroneous initiation; Evidence=; molecular_function mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit ribosome biological_process uc007mkd.1 uc007mkd.2 
ENSMUST00000106448.9 Eif2b3 ENSMUST00000106448.9 eukaryotic translation initiation factor 2B, subunit 3, transcript variant 3 (from RefSeq NM_001355225.1) B1AUN2 B1AUN2_MOUSE ENSMUST00000106448.1 ENSMUST00000106448.2 ENSMUST00000106448.3 ENSMUST00000106448.4 ENSMUST00000106448.5 ENSMUST00000106448.6 ENSMUST00000106448.7 ENSMUST00000106448.8 Eif2b3 NM_001355225 uc012djo.1 uc012djo.2 uc012djo.3 Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP. Complex of five different subunits; alpha, beta, gamma, delta and epsilon. Belongs to the eIF-2B gamma/epsilon subunits family. translation initiation factor activity guanyl-nucleotide exchange factor activity cytoplasm eukaryotic translation initiation factor 2B complex translational initiation translation factor activity, RNA binding biosynthetic process response to heat response to glucose oligodendrocyte development nucleotidyltransferase activity hippocampus development response to peptide hormone T cell receptor signaling pathway uc012djo.1 uc012djo.2 uc012djo.3 
ENSMUST00000106454.8 H3f3b ENSMUST00000106454.8 Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (from UniProt P84244) AK011431 ENSMUST00000106454.1 ENSMUST00000106454.2 ENSMUST00000106454.3 ENSMUST00000106454.4 ENSMUST00000106454.5 ENSMUST00000106454.6 ENSMUST00000106454.7 H3-3a H3-3b H3.3a H3.3b H33_MOUSE H3f3a H3f3b P06351 P33155 P84244 Q3TW79 Q3U6D6 Q569U8 Q5HZY8 Q6TXQ5 Q8VDJ2 Q9D0H3 Q9V3W4 uc288dpt.1 uc288dpt.2 Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes. Interacts with ZMYND11; when trimethylated at 'Lys- 36' (H3.3K36me3). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). Interacts with ASF1A, MCM2, NASP and SPT2 (By similarity). Nucleus. Chromosome. Expressed throughout the cell cycle independently of DNA synthesis. Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with ZMYND11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains (By similarity). Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3). Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters. Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double- strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes. metaphase chromosomes. Ubiquitinated. Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H3 family. Sequence=AAH92300.1; Type=Frameshift; Evidence=; Sequence=BAB27616.1; Type=Frameshift; Evidence=; Sequence=BAE35387.1; Type=Frameshift; Evidence=; nuclear chromosome nuclear chromosome, telomeric region nucleosome nuclear nucleosome RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding osteoblast differentiation Barr body DNA binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-independent nucleosome assembly nucleus organization spermatogenesis spermatid development single fertilization brain development embryo implantation cell proliferation male gonad development response to hormone positive regulation of cell growth nucleosomal DNA binding pericentric heterochromatin assembly telomeric heterochromatin assembly macromolecular complex multicellular organism growth muscle cell differentiation protein heterodimerization activity oogenesis regulation of centromere complex assembly negative regulation of chromosome condensation uc288dpt.1 uc288dpt.2 
ENSMUST00000106460.9 Itgb4 ENSMUST00000106460.9 integrin beta 4, transcript variant 3 (from RefSeq NM_001405127.1) A2A863 A2A865 A2A866 ENSMUST00000106460.1 ENSMUST00000106460.2 ENSMUST00000106460.3 ENSMUST00000106460.4 ENSMUST00000106460.5 ENSMUST00000106460.6 ENSMUST00000106460.7 ENSMUST00000106460.8 ITB4_MOUSE NM_001405127 Q6PCS0 Q8R3J1 Q91W15 uc288dpo.1 uc288dpo.2 Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6. Interacts (via cytoplasmic region) with COL17A1 (via cytoplasmic region). Interacts (via cytoplasmic region) with DST isoform 3 (via N-terminus). Interacts (via cytoplasmic domain) with DST (via N-terminus). Interacts with RAC1. ITGA6:ITGB4 is found in a ternary complex with NRG1 and ERBB3. ITGA6:ITGB4 is found in a ternary complex with IGF1 and IGF1R. ITGA6:ITGB4 interacts with IGF2. Cell membrane ; Single-pass type I membrane protein Cell membrane ; Lipid- anchor Cell junction, hemidesmosome Note=Colocalizes with DST at the leading edge of migrating keratinocytes. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2A863-1; Sequence=Displayed; Name=2; IsoId=A2A863-2; Sequence=VSP_037636; Name=3; IsoId=A2A863-3; Sequence=VSP_037636, VSP_037637; The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230. The VWFA domain (or beta I domain) contains three cation- binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site. Palmitoylated by DHHC3 at several cysteines of the membrane- proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secondary association with tertaspanins (By similarity). Belongs to the integrin beta chain family. G-protein coupled receptor binding integrin binding protein binding basement membrane cytoplasm plasma membrane cell cortex autophagy cell communication cell adhesion cell-matrix adhesion integrin-mediated signaling pathway integrin complex response to wounding basal plasma membrane cell surface membrane integral component of membrane cell migration myelination in peripheral nervous system cell junction hemidesmosome cell leading edge hemidesmosome assembly peripheral nervous system myelin formation cell adhesion mediated by integrin nail development receptor complex skin development filopodium assembly digestive tract development cell motility trophoblast cell migration renal system development amelogenesis insulin-like growth factor I binding neuregulin binding uc288dpo.1 uc288dpo.2 
ENSMUST00000106462.9 Ccdc163 ENSMUST00000106462.9 Ccdc163 (from geneSymbol) A8Y5M9 A8Y5M9_MOUSE AK002768 Ccdc163 ENSMUST00000106462.1 ENSMUST00000106462.2 ENSMUST00000106462.3 ENSMUST00000106462.4 ENSMUST00000106462.5 ENSMUST00000106462.6 ENSMUST00000106462.7 ENSMUST00000106462.8 uc008uhf.1 uc008uhf.2 uc008uhf.3 molecular_function cellular_component biological_process uc008uhf.1 uc008uhf.2 uc008uhf.3 
ENSMUST00000106466.10 Rwdd3 ENSMUST00000106466.10 RWD domain containing 3, transcript variant 2 (from RefSeq NM_028456.3) ENSMUST00000106466.1 ENSMUST00000106466.2 ENSMUST00000106466.3 ENSMUST00000106466.4 ENSMUST00000106466.5 ENSMUST00000106466.6 ENSMUST00000106466.7 ENSMUST00000106466.8 ENSMUST00000106466.9 NM_028456 Q3UYX7 Q3UYX7_MOUSE Rwdd3 uc008rdp.1 uc008rdp.2 uc008rdp.3 uc008rdp.4 uc008rdp.5 Cytoplasm Nucleus negative regulation of NF-kappaB transcription factor activity positive regulation of protein sumoylation positive regulation of hypoxia-inducible factor-1alpha signaling pathway uc008rdp.1 uc008rdp.2 uc008rdp.3 uc008rdp.4 uc008rdp.5 
ENSMUST00000106473.5 Plppr5 ENSMUST00000106473.5 phospholipid phosphatase related 5, transcript variant 1 (from RefSeq NM_001305451.1) ENSMUST00000106473.1 ENSMUST00000106473.2 ENSMUST00000106473.3 ENSMUST00000106473.4 Lppr5 NM_001305451 PLPR5_MOUSE Plppr5 Q8BIL7 Q8BJ52 Q8K0B6 Q9D606 uc008rdb.1 uc008rdb.2 uc008rdb.3 uc008rdb.4 uc008rdb.5 Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BJ52-1; Sequence=Displayed; Name=2; IsoId=Q8BJ52-2; Sequence=VSP_031829; Belongs to the PA-phosphatase related phosphoesterase family. Has most probably no lipid phosphatase activity (By similarity). Critical residues that support the reaction mechanism in active members of that protein family, including the residues of the active site acting respectively as proton donor and nucleophile, are not conserved. plasma membrane integral component of plasma membrane phospholipid metabolic process phosphatidate phosphatase activity positive regulation of neuron projection development membrane integral component of membrane hydrolase activity phosphatase activity lipid phosphatase activity phospholipid dephosphorylation positive regulation of filopodium assembly uc008rdb.1 uc008rdb.2 uc008rdb.3 uc008rdb.4 uc008rdb.5 
ENSMUST00000106492.3 P3r3urf ENSMUST00000106492.3 Pik3r3 upstream reading frame (from RefSeq NM_001099295.2) B1AUF7 ENSMUST00000106492.1 ENSMUST00000106492.2 NM_001099295 P3URF_MOUSE P3r3urf uc008ugl.1 uc008ugl.2 uc008ugl.3 uc008ugl.4 molecular_function cellular_component biological_process uc008ugl.1 uc008ugl.2 uc008ugl.3 uc008ugl.4 
ENSMUST00000106508.10 Gga3 ENSMUST00000106508.10 golgi associated, gamma adaptin ear containing, ARF binding protein 3, transcript variant 2 (from RefSeq NM_001252067.2) A2A9W7 A2A9W7_MOUSE ENSMUST00000106508.1 ENSMUST00000106508.2 ENSMUST00000106508.3 ENSMUST00000106508.4 ENSMUST00000106508.5 ENSMUST00000106508.6 ENSMUST00000106508.7 ENSMUST00000106508.8 ENSMUST00000106508.9 Gga3 NM_001252067 uc011yho.1 uc011yho.2 uc011yho.3 uc011yho.4 Early endosome membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Membrane ; Peripheral membrane protein Belongs to the GGA protein family. trans-Golgi network intracellular protein transport vesicle-mediated transport ADP-ribosylation factor binding uc011yho.1 uc011yho.2 uc011yho.3 uc011yho.4 
ENSMUST00000106520.9 Rexo5 ENSMUST00000106520.9 RNA exonuclease 5, transcript variant 3 (from RefSeq NM_001370778.1) 2610020H08Rik D3YW29 D3YW29_MOUSE ENSMUST00000106520.1 ENSMUST00000106520.2 ENSMUST00000106520.3 ENSMUST00000106520.4 ENSMUST00000106520.5 ENSMUST00000106520.6 ENSMUST00000106520.7 ENSMUST00000106520.8 NM_001370778 Rexo5 uc291uyo.1 uc291uyo.2 nucleic acid binding RNA binding exonuclease activity nucleus nucleolus nucleic acid phosphodiester bond hydrolysis uc291uyo.1 uc291uyo.2 
ENSMUST00000106521.2 Tex38 ENSMUST00000106521.2 testis expressed 38 (from RefSeq NM_029196.1) 4930544O15Rik D2D552 D2D552_MOUSE ENSMUST00000106521.1 NM_029196 Tex38 Theg4 uc008ufi.1 uc008ufi.2 uc008ufi.3 uc008ufi.4 membrane integral component of membrane uc008ufi.1 uc008ufi.2 uc008ufi.3 uc008ufi.4 
ENSMUST00000106525.9 Efcab14 ENSMUST00000106525.9 EF-hand calcium binding domain 14, transcript variant 2 (from RefSeq NM_001368627.1) A2A8U1 EFC14_MOUSE ENSMUST00000106525.1 ENSMUST00000106525.2 ENSMUST00000106525.3 ENSMUST00000106525.4 ENSMUST00000106525.5 ENSMUST00000106525.6 ENSMUST00000106525.7 ENSMUST00000106525.8 Kiaa0494 NM_001368627 Q3TQN6 Q8BGQ6 Q8BJV7 Q8C0R1 uc008uff.1 uc008uff.2 uc008uff.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGQ6-1; Sequence=Displayed; Name=2; IsoId=Q8BGQ6-2; Sequence=VSP_008512; molecular_function cellular_component biological_process metal ion binding uc008uff.1 uc008uff.2 uc008uff.3 
ENSMUST00000106527.8 Acsm3 ENSMUST00000106527.8 acyl-CoA synthetase medium-chain family member 3, transcript variant 3 (from RefSeq NM_212442.3) ACSM3_MOUSE ENSMUST00000106527.1 ENSMUST00000106527.2 ENSMUST00000106527.3 ENSMUST00000106527.4 ENSMUST00000106527.5 ENSMUST00000106527.6 ENSMUST00000106527.7 NM_212442 Q3UNX5 Q8BRY2 Q91WI1 Q9Z2F3 Q9Z2X0 Sa Sah uc009jls.1 uc009jls.2 uc009jls.3 Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11470804). Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms (PubMed:11470804). Reaction=a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:48340, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:59558, ChEBI:CHEBI:90546, ChEBI:CHEBI:456215; EC=6.2.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48341; Evidence=; Reaction=ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA; Xref=Rhea:RHEA:20373, ChEBI:CHEBI:17272, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392, ChEBI:CHEBI:456215; EC=6.2.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20374; Evidence=; Reaction=ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate; Xref=Rhea:RHEA:46172, ChEBI:CHEBI:17968, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46173; Evidence=; Reaction=2-methylpropanoate + ATP + CoA = 2-methylpropanoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:46176, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:48944, ChEBI:CHEBI:57287, ChEBI:CHEBI:57338, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46177; Evidence=; Reaction=2-methylbutanoate + ATP + CoA = 2-methylbutanoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:46180, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:48946, ChEBI:CHEBI:57287, ChEBI:CHEBI:57336, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46181; Evidence=; Reaction=ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA; Xref=Rhea:RHEA:33631, ChEBI:CHEBI:25646, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33632; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Kinetic parameters: KM=0.92 mM for butyrate ; KM=0.05 mM for isobutyrate ; Mitochondrion Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UNX5-1; Sequence=Displayed; Name=2; IsoId=Q3UNX5-2; Sequence=VSP_028397; Detected in kidney (at protein level). Detected in kidney proximal tubules and in liver. Detected at low levels in testis, stomach, heart and lung. Up-regulated in kidney by androgens. Down-regulated in kidney by estrogens. Levels in kidney are very low in female C57BL/6 mice and in castrated male C57BL/6, 129/SvJ and BALB/c mice. Constitutively expressed in liver. Belongs to the ATP-dependent AMP-binding enzyme family. It is uncertain whether Met-1 or Met-3 is the initiator. Sequence=AAC79656.1; Type=Erroneous initiation; Evidence=; Sequence=AAH15248.1; Type=Erroneous initiation; Evidence=; Sequence=AAL40880.1; Type=Erroneous initiation; Evidence=; Sequence=BAA37141.1; Type=Frameshift; Evidence=; Sequence=BAE38232.1; Type=Erroneous initiation; Evidence=; nucleotide binding catalytic activity acyl-CoA ligase activity fatty-acyl-CoA synthase activity ATP binding mitochondrion mitochondrial matrix lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process acyl-CoA metabolic process fatty acid ligase activity ligase activity propionate CoA-transferase activity metal ion binding butyrate-CoA ligase activity propionate-CoA ligase activity uc009jls.1 uc009jls.2 uc009jls.3 
ENSMUST00000106532.4 Slc16a5 ENSMUST00000106532.4 solute carrier family 16 (monocarboxylic acid transporters), member 5, transcript variant 3 (from RefSeq NM_001359608.1) A0A0A0MQC4 A0A0A0MQC4_MOUSE ENSMUST00000106532.1 ENSMUST00000106532.2 ENSMUST00000106532.3 NM_001359608 Slc16a5 uc007mhq.1 uc007mhq.2 uc007mhq.3 membrane integral component of membrane uc007mhq.1 uc007mhq.2 uc007mhq.3 
ENSMUST00000106543.8 Otop3 ENSMUST00000106543.8 otopetrin 3, transcript variant 2 (from RefSeq NM_001347647.1) A2A6S7 B9EKA4 ENSMUST00000106543.1 ENSMUST00000106543.2 ENSMUST00000106543.3 ENSMUST00000106543.4 ENSMUST00000106543.5 ENSMUST00000106543.6 ENSMUST00000106543.7 NM_001347647 OTOP3_MOUSE Otop3 Q7M736 Q80UF9 Q810B4 uc007mhf.1 uc007mhf.2 uc007mhf.3 Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80UF9-1; Sequence=Displayed; Name=2; IsoId=Q80UF9-2; Sequence=VSP_030162; Expressed in epidermis, small intestine, stomach and retina. Belongs to the otopetrin family. plasma membrane ion transport hydrogen ion channel activity membrane integral component of membrane hydrogen ion transmembrane transport uc007mhf.1 uc007mhf.2 uc007mhf.3 
ENSMUST00000106547.2 Iqck ENSMUST00000106547.2 IQ motif containing K, transcript variant 2 (from RefSeq NM_001081446.2) E9PUC1 E9PUC1_MOUSE ENSMUST00000106547.1 Iqck NM_001081446 uc009jku.1 uc009jku.2 molecular_function cellular_component biological_process uc009jku.1 uc009jku.2 
ENSMUST00000106550.12 Knop1 ENSMUST00000106550.12 lysine rich nucleolar protein 1, transcript variant 1 (from RefSeq NM_023197.4) 2310008H09Rik ENSMUST00000106550.1 ENSMUST00000106550.10 ENSMUST00000106550.11 ENSMUST00000106550.2 ENSMUST00000106550.3 ENSMUST00000106550.4 ENSMUST00000106550.5 ENSMUST00000106550.6 ENSMUST00000106550.7 ENSMUST00000106550.8 ENSMUST00000106550.9 H7BX94 H7BX94_MOUSE Knop1 NM_023197 uc291uwl.1 uc291uwl.2 uc291uwl.3 uc291uwl.1 uc291uwl.2 uc291uwl.3 
ENSMUST00000106554.2 Grin2c ENSMUST00000106554.2 glutamate receptor, ionotropic, NMDA2C (epsilon 3) (from RefSeq NM_010350.2) ENSMUST00000106554.1 NMDE3_MOUSE NM_010350 Q01098 uc007mgx.1 uc007mgx.2 Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1377365). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:1377365). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex (PubMed:27922130). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:8987814). Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro) (PubMed:1377365). Can also form heterotetrameric channels that contain at least one zeta subunit (GRIN1), at least one epsilon subunit, plus GRIN3A or GRIN3B (By similarity). In vivo, the subunit composition may depend on the expression levels of the different subunits (Probable). Interacts with PDZ domains of PATJ and DLG4 (By similarity). Interacts (via PDZ- binding motif) with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane; Multi-pass membrane protein. Detected in cerebellum (at protein level) (PubMed:8987814). Detected in the granule cell layer of the cerebellum (PubMed:1377365). A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter. Mutant mice appear grossly normal (PubMed:8987814). Mossy fiber granule cells from mutant mice present a decrease of the slow component of the excitatory postsynaptic current (PubMed:8987814). Pyramidal neurons in the prefrontal cortex display a reduced dendritic spine density (PubMed:27922130). Besides, the prefrontal cortex has an altered pattern of excitatory and inhibitory synapses (PubMed:27922130). Pyramidal neurons in the prefrontal cortex display a reduced frequency of miniature excitatory postsynaptic currents (mEPSC), together with an increased frequency of miniature inhibitory postsynaptic currents (mIPSC), indicative of a shift in the balance between excitatory and inhibitory membrane currents (PubMed:27922130). The slow component of the excitatory postsynaptic current is nearly abolished in mossy fiber cells from mice lacking both Grin2a and Grin2c (PubMed:8987814). Mice lacking both Grin2a and Grin2c display subtle motor deficits; they have no visible phenotype when performing simple tasks, but have decreased ability to walk across a narrow wooden bar, and are unable to stay on a rapidly rotating rod (PubMed:8987814). Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily. ionotropic glutamate receptor activity NMDA glutamate receptor activity ion channel activity cation channel activity protein binding plasma membrane integral component of plasma membrane ion transport glutamate receptor activity response to wounding ligand-gated ion channel activity membrane integral component of membrane NMDA selective glutamate receptor complex calcium-mediated signaling glutamate-gated calcium ion channel activity cell junction PDZ domain binding directional locomotion ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic signaling receptor activity negative regulation of protein catabolic process regulation of membrane potential synapse postsynaptic membrane protein N-terminus binding modulation of synaptic transmission neuromuscular process controlling balance excitatory postsynaptic potential long-term synaptic potentiation calcium ion transmembrane import into cytosol postsynaptic density membrane glutamatergic synapse protein localization to postsynaptic membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential startle response uc007mgx.1 uc007mgx.2 
ENSMUST00000106557.8 Ccp110 ENSMUST00000106557.8 centriolar coiled coil protein 110, transcript variant 1 (from RefSeq NM_182995.2) CP110_MOUSE Cep110 Cp110 ENSMUST00000106557.1 ENSMUST00000106557.2 ENSMUST00000106557.3 ENSMUST00000106557.4 ENSMUST00000106557.5 ENSMUST00000106557.6 ENSMUST00000106557.7 Kiaa0419 NM_182995 Q6A072 Q7TSH4 uc009jkj.1 uc009jkj.2 uc009jkj.3 uc009jkj.4 Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:23141541). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (PubMed:26965371). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (By similarity). Interacts with CALM1, CETN2, CEP76, CEP104, CEP290 and TALPID3 (By similarity). Interacts with CEP97 (PubMed:35301795). Seems to associate with discrete CETN2, CEP97 and CEP290-containing complexes (By similarity). Interacts with NEURL4 and CCNF; these interactions are not mutually exclusive and both lead to CCP110 ubiquitination and proteasome-dependent degradation (By similarity). Via its interaction with NEURL4, may indirectly interact with HERC2 (By similarity). Interacts with KIF24, leading to its recruitment to centrioles (By similarity). Interacts with USP20 and USP33 (By similarity). Interacts with MPHOSPH9 (By similarity). Interacts (via N-terminal region) with ENKD1 (via central region); ENKD1 competes with CEP97 for binding to CCP110, destabilizing the interaction between CP110 and CEP97 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (PubMed:35301795). Q7TSH4; P62204: Calm3; NbExp=4; IntAct=EBI-646843, EBI-397460; Q7TSH4; Q6A078: Cep290; NbExp=3; IntAct=EBI-646843, EBI-1811999; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body Note=Recruited early and then associates with the growing distal tips (PubMed:23141541). Recruited to the mother centriole by KIF24 (By similarity). Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells (PubMed:23141541). In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact (PubMed:26670998). Recruited at the distal end of the mother centriole by MPHOSPH9 (By similarity). Phosphorylated by CDKs. Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate (By similarity). Lethal within a few hours after birth with multiple defects in organogenesis. Mice show an early block in cilia formation and a phenotype reminiscent of human short rib-polydactyly syndrome. protein binding cytoplasm centrosome centriole microtubule organizing center cytoskeleton cilium centriole replication cell projection organization ciliary basal body organization regulation of cytokinesis macromolecular complex cell projection positive regulation of cilium assembly centrosome duplication negative regulation of cilium assembly uc009jkj.1 uc009jkj.2 uc009jkj.3 uc009jkj.4 
ENSMUST00000106560.10 Skint2 ENSMUST00000106560.10 selection and upkeep of intraepithelial T cells 2, transcript variant 3 (from RefSeq NM_001425821.1) B2ZEZ5 B2ZEZ5_MOUSE E9Q127 ENSMUST00000106560.1 ENSMUST00000106560.2 ENSMUST00000106560.3 ENSMUST00000106560.4 ENSMUST00000106560.5 ENSMUST00000106560.6 ENSMUST00000106560.7 ENSMUST00000106560.8 ENSMUST00000106560.9 NM_001425821 OTTMUSG00000008540 Skint2 uc033ids.1 uc033ids.2 uc033ids.3 May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. Membrane ; Multi- pass membrane protein Belongs to the SKINT family. plasma membrane membrane integral component of membrane uc033ids.1 uc033ids.2 uc033ids.3 
ENSMUST00000106561.8 Cd300lf ENSMUST00000106561.8 CD300 molecule like family member F, transcript variant 1 (from RefSeq NM_001169153.1) A2A6Z1 A2A6Z3 CLM1_MOUSE Clm1 ENSMUST00000106561.1 ENSMUST00000106561.2 ENSMUST00000106561.3 ENSMUST00000106561.4 ENSMUST00000106561.5 ENSMUST00000106561.6 ENSMUST00000106561.7 Lmir3 NM_001169153 Q6PEU7 Q6SJQ7 Q8K4V9 uc007mgn.1 uc007mgn.2 uc007mgn.3 Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:17438331). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells (PubMed:21865548). Plays an important role in the maintenance of immune homeostasis, by promoting macrophage- mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (PubMed:26768664). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide which acts as a ligand (PubMed:23123064). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13- induced signaling (PubMed:26124135). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (By similarity). Inhibits osteoclast formation (PubMed:14662855). Induces macrophage cell death upon engagement (PubMed:18097021). (Microbial infection) Acts as a functional murine norovirus (MNV) receptor that mediates binding to the cell surface and is both necessary and sufficient for viral entry and replication. Primary determinant of MNV species tropism and is sufficient to render cells permissive to infection by MNV. Can render nonmurine mammalian cells susceptible to MNV infection (PubMed:27681626, PubMed:27540007). Interacts with PTPN6/SHP-1 in a tyrosine phosphorylation dependent manner (PubMed:14662855). Interacts with IL4R (PubMed:26124135). Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6SJQ7-1; Sequence=Displayed; Name=2; IsoId=Q6SJQ7-2; Sequence=VSP_020066; Name=3; IsoId=Q6SJQ7-3; Sequence=VSP_020067; Expressed in myeloid cells. Present on the surface of macrophages (at protein level). Highly expressed by alveolar, splenic macrophages and bone marrow-derived dendritic cells. Expression is increased following aeroallergen challenge in macrophages, mast cells, and eosinophils. Up-regulated by interleukin-4/IL-4. Phosphorylated on tyrosine. Belongs to the CD300 family. virus receptor activity phosphatidylserine binding immune system process interleukin-4 receptor binding protein binding plasma membrane lipid binding membrane integral component of membrane osteoclast differentiation negative regulation of mast cell activation negative regulation of MyD88-dependent toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway interleukin-13-mediated signaling pathway viral entry into host cell ceramide binding positive regulation of interleukin-4-mediated signaling pathway negative regulation of apoptotic cell clearance positive regulation of apoptotic cell clearance uc007mgn.1 uc007mgn.2 uc007mgn.3 
ENSMUST00000106566.2 Skint4 ENSMUST00000106566.2 selection and upkeep of intraepithelial T cells 4, transcript variant 1 (from RefSeq NM_178786.4) E9QLU2 E9QLU2_MOUSE ENSMUST00000106566.1 NM_178786 Skint4 uc008uds.1 uc008uds.2 May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. Membrane ; Multi- pass membrane protein Belongs to the SKINT family. membrane integral component of membrane uc008uds.1 uc008uds.2 
ENSMUST00000106568.8 Skint7 ENSMUST00000106568.8 Skint7 (from geneSymbol) A0A0B4J1K7 A0A0B4J1K7_MOUSE AK132639 ENSMUST00000106568.1 ENSMUST00000106568.2 ENSMUST00000106568.3 ENSMUST00000106568.4 ENSMUST00000106568.5 ENSMUST00000106568.6 ENSMUST00000106568.7 Skint7 uc290osz.1 uc290osz.2 membrane integral component of membrane uc290osz.1 uc290osz.2 
ENSMUST00000106578.8 Cd300ld2 ENSMUST00000106578.8 Cd300ld2 (from geneSymbol) A2A7W0 A2A7W0_MOUSE Cd300ld2 ENSMUST00000106578.1 ENSMUST00000106578.2 ENSMUST00000106578.3 ENSMUST00000106578.4 ENSMUST00000106578.5 ENSMUST00000106578.6 ENSMUST00000106578.7 Gm11709 uc288dji.1 uc288dji.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288dji.1 uc288dji.2 
ENSMUST00000106581.5 Cd300lb ENSMUST00000106581.5 Cd300lb (from geneSymbol) A0A0R3P9D2 A0A0R3P9D2_MOUSE AK170613 Cd300lb ENSMUST00000106581.1 ENSMUST00000106581.2 ENSMUST00000106581.3 ENSMUST00000106581.4 uc007mga.1 uc007mga.2 membrane integral component of membrane uc007mga.1 uc007mga.2 
ENSMUST00000106582.9 Cd300a ENSMUST00000106582.9 CD300A molecule, transcript variant 1 (from RefSeq NM_170758.4) B9EIB1 CLM8_MOUSE Clm8 ENSMUST00000106582.1 ENSMUST00000106582.2 ENSMUST00000106582.3 ENSMUST00000106582.4 ENSMUST00000106582.5 ENSMUST00000106582.6 ENSMUST00000106582.7 ENSMUST00000106582.8 Lmir1 Mcpir1 NM_170758 Q6SJQ0 Q7TN56 Q7TSN3 Q8CFN3 uc007mfy.1 uc007mfy.2 uc007mfy.3 Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:12874256, PubMed:12893283, PubMed:16339535). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). Upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 and PTPN11/SHP-2 and INPP5D. Cell membrane ingle-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=b; IsoId=Q6SJQ0-1; Sequence=Displayed; Name=2; Synonyms=a; IsoId=Q6SJQ0-2; Sequence=VSP_031608; Present on the surface of the majority of myeloid cells and a subset of B-cells. Present on the surface of NK cells after IL-12 stimulation. Phosphorylated on tyrosine. N-glycosylated. Belongs to the CD300 family. phosphatidylserine binding immune system process serotonin secretion by mast cell protein binding plasma membrane receptor-mediated endocytosis phosphatidylethanolamine binding negative regulation of serotonin secretion membrane integral component of membrane negative regulation of B cell proliferation positive regulation of phosphoprotein phosphatase activity negative regulation of mast cell activation involved in immune response negative regulation of MyD88-dependent toll-like receptor signaling pathway signaling receptor activity mast cell granule negative regulation of mast cell degranulation negative regulation of MAP kinase activity negative regulation of fibroblast proliferation regulation of T cell receptor signaling pathway negative regulation of B cell receptor signaling pathway negative regulation of NK T cell activation negative regulation of phagocytosis, engulfment negative regulation of neutrophil activation negative regulation of eosinophil activation negative regulation of activation of JAK2 kinase activity negative regulation of eosinophil migration uc007mfy.1 uc007mfy.2 uc007mfy.3 
ENSMUST00000106584.2 Gpr142 ENSMUST00000106584.2 G protein-coupled receptor 142, transcript variant 3 (from RefSeq NM_001379097.1) ENSMUST00000106584.1 Gpr142 NM_001379097 Q1XA02 Q1XA02_MOUSE uc007mfv.1 uc007mfv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity cytosol plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane cell junction uc007mfv.1 uc007mfv.2 
ENSMUST00000106597.10 Elavl4 ENSMUST00000106597.10 ELAV like RNA binding protein 4, transcript variant 1 (from RefSeq NM_010488.5) A2A9R6 A2A9R7 A2A9R8 A2A9S0 A2A9S1 A2A9S2 A2A9S3 ELAV4_MOUSE ENSMUST00000106597.1 ENSMUST00000106597.2 ENSMUST00000106597.3 ENSMUST00000106597.4 ENSMUST00000106597.5 ENSMUST00000106597.6 ENSMUST00000106597.7 ENSMUST00000106597.8 ENSMUST00000106597.9 Hud NM_010488 O55010 Q61701 Q6PHZ3 Q8BVA9 uc008ucw.1 uc008ucw.2 uc008ucw.3 RNA-binding protein that is involved in the post- transcriptional regulation of mRNAs (PubMed:15764704, PubMed:16554442, PubMed:17035636, PubMed:20064466, PubMed:22387028, PubMed:23383270, PubMed:26305964, PubMed:28111162). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:15764704, PubMed:23383270, PubMed:26305964, PubMed:28111162). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (By similarity). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (PubMed:26305964). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (By similarity). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:20064466). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:15764704, PubMed:16554442, PubMed:18218628, PubMed:23383270, PubMed:24599466, PubMed:25692578, PubMed:26305964, PubMed:28111162). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (PubMed:15764704). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (PubMed:26305964). Binds and stabilizes MSI1 mRNA in neural stem cells (PubMed:16554442). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (By similarity). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (By similarity). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (PubMed:24599466). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:28111162). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (PubMed:23383270, PubMed:25692578). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (PubMed:28111162). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (PubMed:20064466). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (PubMed:22387028). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (PubMed:22387028). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich sequences of CALCA pre-mRNA (PubMed:17035636). Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (PubMed:15086518). Associates with the EIF4F cap- binding complex, composed of EIF4G, EIF4A, EIF4E and PABP (PubMed:20064466). Within the EIF4F cap-binding complex, interacts with EIF4A (PubMed:20064466). Interacts with SMN (via Tudor domain) in an RNA-independent manner; the interaction is required for localization of ELAVL4 to RNA granules (By similarity). Interacts with MAP1 light chain LC1 (via C-terminus); the interaction contributes to the association of ELAVL4 with microtubules (PubMed:21288476). Interacts with MAP1 light chain LC2 (PubMed:21288476). Cytoplasm rikaryon Cell projection, dendrite Cell projection, axon Cell projection, growth cone Note=Co-localizes with ribosomal RNA in polysomes. Event=Alternative splicing, Alternative initiation; Named isoforms=10; Name=1; Synonyms=Long; IsoId=Q61701-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q61701-2; Sequence=VSP_005792; Name=3; Synonyms=sv1 , E1b ; IsoId=Q61701-4; Sequence=VSP_060287; Name=4; Synonyms=sv2 ; IsoId=Q61701-5; Sequence=VSP_060287, VSP_060290; Name=5; Synonyms=E1a ; IsoId=Q61701-6; Sequence=VSP_060284, VSP_005792; Name=6; Synonyms=E1a1 ; IsoId=Q61701-7; Sequence=VSP_060285, VSP_060290; Name=7; Synonyms=E1a2 ; IsoId=Q61701-8; Sequence=VSP_060286, VSP_060289; Name=8; Synonyms=E1a3 ; IsoId=Q61701-9; Sequence=VSP_060288, VSP_060290; Name=9; Synonyms=E1c ; IsoId=Q61701-10; Sequence=VSP_060290; Name=10; Synonyms=E1c1 ; IsoId=Q61701-11; Sequence=VSP_060291; Expressed in the brain, including the hippocampus, and in pancreatic beta cells (at protein level) (PubMed:22387028, PubMed:18493953, PubMed:15764704, PubMed:24599466). Expressed in pyramidal neurons of the hippocampal CA3 and CA1 region and in the hilus but not in dentate granule cells (at protein level) (PubMed:15519747). Expressed in the dorsal root ganglion and the spinal cord (at protein level) (PubMed:17035636, PubMed:28111162). Expressed in neural stem and progenitor cells (at protein level) (PubMed:16554442). Expressed in radial glia-like cells and in transient amplifying cells in the subventricular zone (SVZ), and in immature neurons both in the SVZ and the rostral migratory stream as well as in mature neurons in the olfactory bulb (at protein level) (PubMed:26305964). Expressed in testis and in the brain, including the hippocampus, the neocortex and the cerebellum (PubMed:8535975, PubMed:11573004, PubMed:24857657). Expressed in lower- but not upper- layer primary neurons of the mature neocortex, in the hippocampal regions CA1-3 and the dentate gyrus (PubMed:24599466, PubMed:9096138). Expressed in the mitral and granule cells of the olfactory bulb, cerebral cortex, entorhinal cortex, thalamus, medial habenula, amygdala, granule cells of the cerebellum, pons, olivary nucleus, dorsal and ventral spinal cord and in dorsal root ganglia (PubMed:9096138). Expressed in motor neurons (PubMed:21389246). Isoform 4: Expressed in the brain (PubMed:9096138, PubMed:22895702). Isoform 5: Expressed in the brain (PubMed:9096138). Isoform 6: Expressed in the brain (PubMed:22895702). Isoform 7: Expressed in the brain (PubMed:22895702). Isoform 8: Expressed in the brain (PubMed:22895702). Isoform 9: Expressed in the brain (PubMed:22895702). Isoform 10: Expressed in the brain (PubMed:22895702). Isoform 11: Expressed in the brain (PubMed:22895702). At 14 dpc, expressed in the intermediate zone of the cortex (PubMed:9096138). At 15 dpc, high expression in the neocortex, with decreased expression at postnatal day 7 and in adulthood (PubMed:24599466). At 16 dpc and at birth, expressed in the retina, thalamus, hypothalamus, midbrain, pons, dorsal and ventral spinal cord, and the dorsal root ganglia (PubMed:9096138). At birth, expressed in the nasal epithelium, olfactory bulb, trigeminal ganglia, cerebral cortex, the pyramidal cells of the hippocampus and the sympathetic ganglia (PubMed:9096138). Widely expressed in the cerebellum at postnatal day 9 (PubMed:9096138). Isoform 4: Highly expressed in the brain at 10 dpc to 14 dpc, with decreased expression at 16 dpc and at postnatal day 8 (PubMed:9096138). Isoform 5: Highly expressed in the brain at 10 dpc, with decreased expression at 16 dpc and at postnatal day 8 (PubMed:9096138). Isoform 6: Expressed in the brain at 14 dpc (PubMed:22895702). Isoform 7: Expressed in the brain at 14 dpc (PubMed:9096138). Isoform 8: Expressed in the brain at 14 dpc (PubMed:9096138). Isoform 9: Expressed in the brain at 14 dpc (PubMed:9096138). Isoform 10: Expressed in the brain at 14 dpc, including the amygdala, hippocampus and cerebral cortex, and strong expression in the olfactory bulb and retina (PubMed:22895702). Isoform 11: Expressed in the brain at 14 dpc (PubMed:9096138). Up-regulated by glucose and by insulin (PubMed:22387028). Up-regulated after memory training in radial arm maze experiments (PubMed:11573004). Up-regulated after sciatic nerve injury (PubMed:28111162). Up-regulated during adult neuronal stem cell differentiation (PubMed:26305964). The RRM 3 domain is required for binding to poly(A) RNA, for the association with polysomes and with the EIF4F cap-binding complex and for the stimulation of translation (PubMed:20064466). The RRM 1 and RRM 2 domains may contribute to polysome association and stimulation of translation (PubMed:20064466). Methylated by CARM1, which leads to reduced RNA-binding activity and enhanced interaction with SMN (By similarity). Methylation at Arg- 248 by CARM1 weakens protective binding to the 3'UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state (By similarity). Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity). Transiently impaired neurite extensions of several cranial nerves, including glossopharyngeal nerve, hypoglossal nerve, trigeminal nerve and acousticofacial nerves in the midembryonic nervous system at 10.5 dpc, however no developmental delays of the nervous system in later-stage embryos at 14 dpc are obvious (PubMed:15764704). By postnatal weeks 4 to 8, 70-80% of the mice exhibit an abnormal clasping reflex of the hind limbs upon being suspended by the tail (PubMed:15764704). Decreased motor coordination, as impaired performance on an accelerating rotarod is observed (PubMed:15764704). Embryonic neural stem cells exhibit enhanced cell renewal capacity and decreased ability to differentiate into neurons (PubMed:15764704). Failure of neural progenitor cells to leave the cell cycle, resulting in increased apoptosis and in reduced production of postmitotic neurons (PubMed:15764704). Increased number of slowly dividing cells in the subventricular zone (PubMed:15764704). High insulin levels in pancreatic beta cells (PubMed:22387028). At 28 dpc, a decreased number of lower layer neocortical neurons is observed and lower layer neocortical neurons and CA3 hippocampal neurons exhibit a decreased dendritic complexity with fewer basal and apical branchpoints, fewer branch endings and shorter basal dendrites (PubMed:24599466). Basal branching deficiency in neocortical lower layer neurons and in hippocampal CA3 neurons persists into adulthood at 90 dpc (PubMed:24599466). Increased time spent in low-energy-expending activities and less in the high-energy activity of locomotion, indicating an anxiety response (PubMed:24599466). Decreased performance in finding a hidden platform in a water bath (Morris water maze test), suggesting difficulty in learning, lack of avoidance of the open arm in a elevated plus maze test, suggesting an aberrant response to anxiety- producing environments, and higher susceptibility to auditory-induced seizures (PubMed:24599466). RNAi-mediated knockdown in the neocortex at 13.5 dpc results in reduced neurite outgrowth (PubMed:24599466). RNAi- mediated knockdown in neural stem/progenitor cells in the adult subventricular zone impairs early neuronal differentiation (PubMed:26305964). [Isoform 3]: Produced by alternative initiation. [Isoform 4]: Produced by alternative splicing of isoform 4. [Isoform 5]: Produced by alternative initiation. [Isoform 6]: Produced by alternative initiation. [Isoform 7]: Produced by alternative initiation. [Isoform 8]: Produced by alternative initiation. [Isoform 9]: Produced by alternative splicing of isoform 1. [Isoform 10]: Produced by alternative initiation. Belongs to the RRM elav family. nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding nucleus nuclear envelope cytoplasm cytosol cytoskeleton learning locomotory behavior membrane neuron differentiation dendrite growth cone mRNA 3'-UTR AU-rich region binding polysomal ribosome neuronal cell body regulation of mRNA stability translation regulator activity dendrite morphogenesis glutamatergic synapse regulation of translation at synapse, modulating synaptic transmission positive regulation of dendrite development ribonucleoprotein complex uc008ucw.1 uc008ucw.2 uc008ucw.3 
ENSMUST00000106602.10 Rpl38 ENSMUST00000106602.10 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). (from UniProt Q9JJI8) AB037665 ENSMUST00000106602.1 ENSMUST00000106602.2 ENSMUST00000106602.3 ENSMUST00000106602.4 ENSMUST00000106602.5 ENSMUST00000106602.6 ENSMUST00000106602.7 ENSMUST00000106602.8 ENSMUST00000106602.9 Q9JJI8 RL38_MOUSE uc007mfl.1 uc007mfl.2 uc007mfl.3 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Cytoplasm Belongs to the eukaryotic ribosomal protein eL38 family. skeletal system development ossification cytoplasmic translation structural constituent of ribosome ribosome translation regulation of translation sensory perception of sound postsynaptic density cytosolic large ribosomal subunit eukaryotic 80S initiation complex 90S preribosome assembly middle ear morphogenesis polysomal ribosome synapse axial mesoderm development uc007mfl.1 uc007mfl.2 uc007mfl.3 
ENSMUST00000106604.3 1700092K14Rik ENSMUST00000106604.3 1700092K14Rik (from geneSymbol) AK007042 ENSMUST00000106604.1 ENSMUST00000106604.2 uc007mfi.1 uc007mfi.2 uc007mfi.3 uc007mfi.1 uc007mfi.2 uc007mfi.3 
ENSMUST00000106609.8 Clcc1 ENSMUST00000106609.8 chloride channel CLIC-like 1, transcript variant 2 (from RefSeq NM_145543.2) A2AEK9 CLCC1_MOUSE ENSMUST00000106609.1 ENSMUST00000106609.2 ENSMUST00000106609.3 ENSMUST00000106609.4 ENSMUST00000106609.5 ENSMUST00000106609.6 ENSMUST00000106609.7 NM_145543 Q99LI2 uc008qzk.1 uc008qzk.2 uc008qzk.3 Seems to act as a chloride ion channel (By similarity). Plays a role in retina development (PubMed:30157172). Interacts with mitochondrial protein PIGBOS1 (via C-terminus); the interaction occurs at the mitochondria-associated endoplasmic reticulum (ER) membrane, a zone of contact between the ER and mitochondrial membranes, but does not appear to play a role in ER- mitochondria tethering and is not affected by ER stress (By similarity). Interacts with CALR (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Nucleus membrane ; Multi-pass membrane protein Note=Within the endoplasmic reticulum (ER), localizes to the mitochondria-associated ER membrane, a zone of contact between the ER and mitochondrial membranes. Embryonic lethal. Belongs to the chloride channel MCLC family. Sequence=CAM17753.1; Type=Erroneous gene model prediction; Evidence=; chloride channel activity nucleus cytoplasm endoplasmic reticulum Golgi apparatus ion transport chloride transport membrane integral component of membrane chloride channel complex intracellular membrane-bounded organelle chloride transmembrane transport uc008qzk.1 uc008qzk.2 uc008qzk.3 
ENSMUST00000106618.8 Ttc39a ENSMUST00000106618.8 tetratricopeptide repeat domain 39A, transcript variant 1 (from RefSeq NM_001145948.2) A2ACN9 A2ACP1 A2ACP2 A2ACP3 A2ACP4 ENSMUST00000106618.1 ENSMUST00000106618.2 ENSMUST00000106618.3 ENSMUST00000106618.4 ENSMUST00000106618.5 ENSMUST00000106618.6 ENSMUST00000106618.7 Kiaa0452 NM_001145948 Q6A067 Q8C612 Q8CFL5 Q8K1A9 TT39A_MOUSE uc008uck.1 uc008uck.2 uc008uck.3 uc008uck.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2ACP1-1; Sequence=Displayed; Name=2; IsoId=A2ACP1-2; Sequence=VSP_026354; Belongs to the TTC39 family. Sequence=BAC36475.1; Type=Frameshift; Evidence=; Sequence=CAM13655.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM13658.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM13659.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM13660.1; Type=Erroneous gene model prediction; Evidence=; molecular_function cellular_component biological_process uc008uck.1 uc008uck.2 uc008uck.3 uc008uck.4 
ENSMUST00000106625.10 Elapor1 ENSMUST00000106625.10 endosome-lysosome associated apoptosis and autophagy regulator 1, transcript variant 4 (from RefSeq NM_001358064.1) 5330417C22Rik A0A0A0MQC6 A0A0A0MQC6_MOUSE ENSMUST00000106625.1 ENSMUST00000106625.2 ENSMUST00000106625.3 ENSMUST00000106625.4 ENSMUST00000106625.5 ENSMUST00000106625.6 ENSMUST00000106625.7 ENSMUST00000106625.8 ENSMUST00000106625.9 Elapor1 NM_001358064 uc057lgk.1 uc057lgk.2 uc057lgk.3 Cell membrane ; Single-pass type I membrane protein Belongs to the ELAPOR family. autophagosome assembly lysosome late endosome trans-Golgi network plasma membrane integral component of plasma membrane cellular response to starvation membrane integral component of membrane positive regulation of vacuole organization positive regulation of autophagosome assembly uc057lgk.1 uc057lgk.2 uc057lgk.3 
ENSMUST00000106633.10 Slc39a11 ENSMUST00000106633.10 solute carrier family 39 (metal ion transporter), member 11, transcript variant 10 (from RefSeq NM_001362944.1) ENSMUST00000106633.1 ENSMUST00000106633.2 ENSMUST00000106633.3 ENSMUST00000106633.4 ENSMUST00000106633.5 ENSMUST00000106633.6 ENSMUST00000106633.7 ENSMUST00000106633.8 ENSMUST00000106633.9 NM_001362944 Q8BWY7 Q8BZ08 Q8K0E0 Q8VE72 Q99KI2 Q9D8J0 S39AB_MOUSE Zip11 uc007men.1 uc007men.2 uc007men.3 uc007men.4 Zinc importer that regulates cytosolic zinc concentration either via zinc influx from the extracellular compartment or efflux from intracellular organelles such as Golgi apparatus. May transport copper ions as well. The transport mechanism remains to be elucidated. Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29353; Evidence=; Reaction=Cu(2+)(in) = Cu(2+)(out); Xref=Rhea:RHEA:28703, ChEBI:CHEBI:29036; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28705; Evidence=; Cell membrane ; Multi-pass membrane protein Nucleus Cytoplasm Golgi apparatus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BWY7-1; Sequence=Displayed; Name=2; IsoId=Q8BWY7-2; Sequence=VSP_028977, VSP_028978; Name=3; IsoId=Q8BWY7-3; Sequence=VSP_028978; Highly expressed in the testes and portions of the digestive system including the stomach, ileum and cecum. In contrast, expressed at very low levels in liver, duodenum, jejunum, and colon. Transcriptionally up-regulated by zinc (PubMed:23643525). Up-regulated during lactation. Belongs to the ZIP transporter (TC 2.A.5) family. Sequence=AAH04643.1; Type=Erroneous initiation; Evidence=; Sequence=AAH04643.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; zinc ion transmembrane transporter activity nucleus cytoplasm Golgi apparatus plasma membrane ion transport zinc II ion transport membrane integral component of membrane metal ion transport metal ion transmembrane transporter activity transmembrane transport zinc II ion transmembrane transport uc007men.1 uc007men.2 uc007men.3 uc007men.4 
ENSMUST00000106636.8 Kcnj16 ENSMUST00000106636.8 potassium inwardly-rectifying channel, subfamily J, member 16, transcript variant 4 (from RefSeq NM_010604.3) ENSMUST00000106636.1 ENSMUST00000106636.2 ENSMUST00000106636.3 ENSMUST00000106636.4 ENSMUST00000106636.5 ENSMUST00000106636.6 ENSMUST00000106636.7 KCJ16_MOUSE NM_010604 Q8BH37 Q9Z307 uc007mdu.1 uc007mdu.2 uc007mdu.3 Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules. Heterodimer with Kir4.1/KCNJ10; this interaction is required for KCNJ16 localization to the basolateral membrane in kidney cells. As a heterodimer with KCNJ10, may interact with MAGI1; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney cells. May form heterodimers with Kir2.1/KCNJ2. Membrane ; Multi- pass membrane protein Basolateral cell membrane Note=In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10. Abundantly expressed in the proximal and distal segments of the nephron. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily. inward rectifier potassium channel activity voltage-gated ion channel activity plasma membrane ion transport potassium ion transport membrane integral component of membrane basolateral plasma membrane regulation of ion transmembrane transport potassium ion import across plasma membrane uc007mdu.1 uc007mdu.2 uc007mdu.3 
ENSMUST00000106640.2 Parva ENSMUST00000106640.2 Belongs to the parvin family. (from UniProt Q3UF75) AK148878 ENSMUST00000106640.1 Parva Q3UF75 Q3UF75_MOUSE uc009jgu.1 uc009jgu.2 uc009jgu.3 Belongs to the parvin family. actin binding cell adhesion actin cytoskeleton reorganization uc009jgu.1 uc009jgu.2 uc009jgu.3 
ENSMUST00000106644.9 Nrdc ENSMUST00000106644.9 nardilysin convertase, transcript variant 1 (from RefSeq NM_001347169.2) A2A9Q2 A2A9Q2_MOUSE ENSMUST00000106644.1 ENSMUST00000106644.2 ENSMUST00000106644.3 ENSMUST00000106644.4 ENSMUST00000106644.5 ENSMUST00000106644.6 ENSMUST00000106644.7 ENSMUST00000106644.8 NM_001347169 Nrdc uc057ljp.1 uc057ljp.2 uc057ljp.3 Belongs to the peptidase M16 family. catalytic activity metalloendopeptidase activity mitochondrion proteolysis metal ion binding positive regulation of membrane protein ectodomain proteolysis regulation of endopeptidase activity uc057ljp.1 uc057ljp.2 uc057ljp.3 
ENSMUST00000106650.9 Rab3b ENSMUST00000106650.9 RAB3B, member RAS oncogene family (from RefSeq NM_023537.5) ENSMUST00000106650.1 ENSMUST00000106650.2 ENSMUST00000106650.3 ENSMUST00000106650.4 ENSMUST00000106650.5 ENSMUST00000106650.6 ENSMUST00000106650.7 ENSMUST00000106650.8 NM_023537 Q80WV9 Q920F1 Q9CZT8 RAB3B_MOUSE uc008ubu.1 uc008ubu.2 uc008ubu.3 Protein transport. Probably involved in vesicular traffic (By similarity). Interacts with RIMS1, RIMS2, RPH3A and RPH3AL (PubMed:12578829). The GTP-bound form interacts with GAS8/DRC4 (via coiled-coil domains) (PubMed:18396146). Interacts with GDI2, CHM and CHML; phosphorylation at Thr-86 disrupts these interactions (By similarity). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (PubMed:18849981). Cell membrane ; Lipid-anchor ; Cytoplasmic side Golgi apparatus Note=Colocalizes with GAS8/DRC4 in the Golgi apparatus. Abundantly expressed in testis, lung and brain. Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitor GDI2. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity protein binding GTP binding cytoplasm endosome Golgi apparatus cytosol plasma membrane intracellular protein transport vesicle docking involved in exocytosis synaptic vesicle protein secretion protein transport membrane regulation of exocytosis peptidyl-cysteine methylation GDP binding antigen processing and presentation GTP-dependent protein binding myosin V binding vesicle Rab protein signal transduction perinuclear region of cytoplasm positive regulation of dopamine uptake involved in synaptic transmission protein localization to plasma membrane regulation of vesicle size anchored component of synaptic vesicle membrane secretory granule uc008ubu.1 uc008ubu.2 uc008ubu.3 
ENSMUST00000106655.2 Cyb561d1 ENSMUST00000106655.2 cytochrome b-561 domain containing 1, transcript variant 1 (from RefSeq NM_001081320.2) A2AE42 B2RPT5 C56D1_MOUSE Cyb561d1 ENSMUST00000106655.1 NM_001081320 uc008qyj.1 uc008qyj.2 uc008qyj.3 Probable transmembrane reductase that may use ascorbate as an electron donor and transfer electrons across membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in another cellular compartment. Reaction=L-ascorbate(in) + monodehydro-L-ascorbate radical(out) = L- ascorbate(out) + monodehydro-L-ascorbate radical(in); Xref=Rhea:RHEA:66524, ChEBI:CHEBI:38290, ChEBI:CHEBI:59513; Evidence=; Reaction=Fe(3+)(out) + L-ascorbate(in) = Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in); Xref=Rhea:RHEA:30403, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:38290, ChEBI:CHEBI:59513; EC=7.2.1.3; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 2 heme b groups non-covalently. ; Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane metal ion binding oxidation-reduction process uc008qyj.1 uc008qyj.2 uc008qyj.3 
ENSMUST00000106656.2 Amigo1 ENSMUST00000106656.2 adhesion molecule with Ig like domain 1, transcript variant 1 (from RefSeq NM_146137.4) A2AE40 AMGO1_MOUSE Ali2 Amigo Amigo1 ENSMUST00000106656.1 Kiaa1163 NM_146137 Q69ZQ0 Q80ZD8 Q8R5D4 Q921U9 uc008qyh.1 uc008qyh.2 uc008qyh.3 uc008qyh.4 Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity). Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:22056818). Homodimer, and heterodimer with AMIGO2 and AMIGO3 (PubMed:21983541). Interacts with KCNB1 (PubMed:22056818). Q80ZD8; Q03717: Kcnb1; NbExp=4; IntAct=EBI-7511393, EBI-7511364; Cell membrane ingle-pass type I membrane protein Perikaryon Cell projection, dendrite Note=Colocalizes with KCNB1 at high- density somatodendritic clusters on the surface of hippocampal and cortical neurons (PubMed:22056818). Associated with axons of neuronal cells (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q80ZD8-1; Sequence=Displayed; Name=2 ; IsoId=Q80ZD8-2; Sequence=VSP_014166, VSP_014167; Expressed in hippocampal and cortical neurons (at protein level) (PubMed:22056818). High levels in cerebellum, cerebrum, and retina. Low levels in liver, kidney, small intestine, spleen, lung and heart. The LRR repeat region mediates homodimerization. Belongs to the immunoglobulin superfamily. AMIGO family. Sequence=AAH22907.1; Type=Frameshift; Evidence=; Sequence=BAD32396.1; Type=Erroneous initiation; Evidence=; protein binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules multicellular organism development nervous system development axonogenesis axonal fasciculation brain development positive regulation of neuron projection development potassium channel regulator activity membrane integral component of membrane cell differentiation dendrite neuronal cell body membrane myelination cell projection neuronal cell body perikaryon positive regulation of axonogenesis positive regulation of synapse assembly positive regulation of potassium ion transmembrane transport positive regulation of voltage-gated potassium channel activity cellular response to L-glutamate pericellular basket voltage-gated potassium channel complex uc008qyh.1 uc008qyh.2 uc008qyh.3 uc008qyh.4 
ENSMUST00000106657.8 Zfyve9 ENSMUST00000106657.8 zinc finger, FYVE domain containing 9, transcript variant 6 (from RefSeq NM_001426211.1) A2A8R0 A2A8R0_MOUSE ENSMUST00000106657.1 ENSMUST00000106657.2 ENSMUST00000106657.3 ENSMUST00000106657.4 ENSMUST00000106657.5 ENSMUST00000106657.6 ENSMUST00000106657.7 NM_001426211 Zfyve9 uc057ljo.1 uc057ljo.2 uc057ljo.3 Cytoplasm Early endosome membrane protein binding 1-phosphatidylinositol binding cytoplasm endosome early endosome cytosol transforming growth factor beta receptor signaling pathway membrane endosomal transport regulation of transforming growth factor beta receptor signaling pathway protein domain specific binding early endosome membrane macromolecular complex intracellular membrane-bounded organelle SMAD binding metal ion binding uc057ljo.1 uc057ljo.2 uc057ljo.3 
ENSMUST00000106663.2 Galnt18 ENSMUST00000106663.2 polypeptide N-acetylgalactosaminyltransferase 18, transcript variant 2 (from RefSeq NM_001360903.1) ENSMUST00000106663.1 Galnt18 Galntl4 NM_001360903 Q59J91 Q59J91_MOUSE mpp-GalNAc-T18(O18) uc009jgd.1 uc009jgd.2 Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Golgi membrane Golgi apparatus protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups carbohydrate binding uc009jgd.1 uc009jgd.2 
ENSMUST00000106677.8 Prkar1a ENSMUST00000106677.8 protein kinase, cAMP dependent regulatory, type I, alpha, transcript variant 3 (from RefSeq NM_021880.4) ENSMUST00000106677.1 ENSMUST00000106677.2 ENSMUST00000106677.3 ENSMUST00000106677.4 ENSMUST00000106677.5 ENSMUST00000106677.6 ENSMUST00000106677.7 KAP0_MOUSE NM_021880 Q3UKU7 Q9DBC7 Q9JHR5 Q9JHR6 uc029rpm.1 uc029rpm.2 uc029rpm.3 uc029rpm.4 The encoded protein is a regulatory subunit of the cAMP-dependent protein kinase (PKA) complex, which is responsible for transducing most of the cAMP signals in eukaryotic cells. The inactive PKA complex contains two regulatory and two catalytic subunits. Binding of cAMP dissociates the complex, allowing monomeric catalytic subunits to phosphorylate cytosolic proteins or induce gene expression in the nucleus. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.118404.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164136 [ECO:0000348] ##Evidence-Data-END## Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKACA and PRKACB (By similarity). PRKAR1A also interacts with RFC2; the complex may be involved in cell survival. Interacts with AKAP4 (PubMed:9852104). Interacts with RARA; the interaction occurs in the presence of cAMP or FSH and regulates RARA transcriptional activity. Interacts with the phosphorylated form of PJA2. Interacts with PRKX; regulates this cAMP-dependent protein kinase (By similarity). Interacts with CBFA2T3 (PubMed:20138877). Interacts with smAKAP; this interaction may target PRKAR1A to the plasma membrane. Interacts with AICDA (By similarity). Q9DBC7; O54918-1: Bcl2l11; NbExp=2; IntAct=EBI-645677, EBI-526076; Cell membrane The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity. Two types of regulatory chains are found: type I, which predominates in skeletal muscle, and type II, which predominates in cardiac muscle. Belongs to the cAMP-dependent kinase regulatory chain family. nucleotide binding mesoderm formation immunological synapse regulation of protein phosphorylation cAMP-dependent protein kinase inhibitor activity protein binding cytoplasm cytosol plasma membrane axoneme cAMP-dependent protein kinase complex protein phosphorylation negative regulation of protein kinase activity female meiotic division heart development cell proliferation cAMP-dependent protein kinase regulator activity animal organ morphogenesis membrane protein domain specific binding cGMP-mediated signaling cAMP binding nucleotide-activated protein kinase complex neuromuscular junction ubiquitin protein ligase binding macromolecular complex protein kinase A catalytic subunit binding plasma membrane raft synapse sarcomere organization negative regulation of meiotic nuclear division regulation of protein kinase activity negative regulation of activated T cell proliferation 3',5'-cyclic-GMP phosphodiesterase activity cardiac muscle cell proliferation glutamatergic synapse negative regulation of cAMP-dependent protein kinase activity uc029rpm.1 uc029rpm.2 uc029rpm.3 uc029rpm.4 
ENSMUST00000106685.9 Gstm6 ENSMUST00000106685.9 glutathione S-transferase, mu 6, transcript variant 4 (from RefSeq NM_008184.4) ENSMUST00000106685.1 ENSMUST00000106685.2 ENSMUST00000106685.3 ENSMUST00000106685.4 ENSMUST00000106685.5 ENSMUST00000106685.6 ENSMUST00000106685.7 ENSMUST00000106685.8 GSTM6_MOUSE Gstm5 NM_008184 O35660 O35661 Q8K0C3 uc008qxu.1 uc008qxu.2 uc008qxu.3 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Homodimer. Cytoplasm Expressed in liver, stomach and small intestine. Not expressed in spleen, kidney, colon, heart, muscle, brain or lung. Belongs to the GST superfamily. Mu family. glutathione transferase activity cytoplasm glutathione metabolic process transferase activity uc008qxu.1 uc008qxu.2 uc008qxu.3 
ENSMUST00000106703.4 Gm10961 ENSMUST00000106703.4 Gm10961 (from geneSymbol) ENSMUST00000106703.1 ENSMUST00000106703.2 ENSMUST00000106703.3 uc290iou.1 uc290iou.2 uc290iou.3 uc290iou.4 uc290iou.1 uc290iou.2 uc290iou.3 uc290iou.4 
ENSMUST00000106709.9 Podn ENSMUST00000106709.9 podocan, transcript variant 5 (from RefSeq NM_001425124.1) A2A8F3 ENSMUST00000106709.1 ENSMUST00000106709.2 ENSMUST00000106709.3 ENSMUST00000106709.4 ENSMUST00000106709.5 ENSMUST00000106709.6 ENSMUST00000106709.7 ENSMUST00000106709.8 NM_001425124 PODN_MOUSE Q7TQ62 Q8BM45 uc008uaq.1 uc008uaq.2 uc008uaq.3 Negatively regulates cell proliferation and cell migration, especially in smooth muscle cells. Binds to type I collagen. Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TQ62-1; Sequence=Displayed; Name=2; IsoId=Q7TQ62-2; Sequence=VSP_021785; Kidney. Expressed in podocytes and likely vascular endothelial cells within the glomerulus. Detected at low levels in normal embryonic kidney from embryonic day 14 through birth. Expression increases dramatically within 24 hours following birth and maximal levels coincide with the completion of morphogenesis at 2 weeks of age. N-glycosylated. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class V subfamily. collagen binding extracellular region extracellular space cytoplasm negative regulation of cell proliferation negative regulation of cell migration uc008uaq.1 uc008uaq.2 uc008uaq.3 
ENSMUST00000106710.3 E030025P04Rik ENSMUST00000106710.3 RIKEN cDNA E030025P04 gene (from RefSeq NR_037978.1) A2A6V5 A2A6V5_MOUSE E030025P04Rik ENSMUST00000106710.1 ENSMUST00000106710.2 NR_037978 uc007mbw.1 uc007mbw.2 uc007mbw.3 uc007mbw.4 uc007mbw.5 molecular_function cellular_component biological_process uc007mbw.1 uc007mbw.2 uc007mbw.3 uc007mbw.4 uc007mbw.5 
ENSMUST00000106729.8 Scube2 ENSMUST00000106729.8 signal peptide, CUB domain, EGF-like 2 (from RefSeq NM_020052.2) D3YVM9 D3YVM9_MOUSE ENSMUST00000106729.1 ENSMUST00000106729.2 ENSMUST00000106729.3 ENSMUST00000106729.4 ENSMUST00000106729.5 ENSMUST00000106729.6 ENSMUST00000106729.7 NM_020052 Scube2 uc009jej.1 uc009jej.2 uc009jej.3 uc009jej.4 Secreted Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding uc009jej.1 uc009jej.2 uc009jej.3 uc009jej.4 
ENSMUST00000106741.10 Trim66 ENSMUST00000106741.10 tripartite motif-containing 66, transcript variant 1 (from RefSeq NM_001170912.1) E9QKN7 E9QLR8 ENSMUST00000106741.1 ENSMUST00000106741.2 ENSMUST00000106741.3 ENSMUST00000106741.4 ENSMUST00000106741.5 ENSMUST00000106741.6 ENSMUST00000106741.7 ENSMUST00000106741.8 ENSMUST00000106741.9 NM_001170912 Q5SEK4 Q5SEK5 Q924W6 TRI66_MOUSE Tif1d uc009jdq.1 uc009jdq.2 uc009jdq.3 uc009jdq.4 May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association. Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif. Nucleus Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q924W6-1; Sequence=Displayed; Name=2; IsoId=Q924W6-2; Sequence=VSP_061682, VSP_061683, VSP_061684; Name=3; IsoId=Q924W6-3; Sequence=VSP_061682; Predominant in testis, specifically in elongating spermatids. No significant expression in testis of 2- or 3- week-old mouse, but clear detection at the age of 4 weeks. chromatin binding protein binding nucleus nucleoplasm zinc ion binding chromocenter aggresome protein homodimerization activity negative regulation of transcription, DNA-templated metal ion binding uc009jdq.1 uc009jdq.2 uc009jdq.3 uc009jdq.4 
ENSMUST00000106749.8 Ift25 ENSMUST00000106749.8 intraflagellar transport 25, transcript variant 3 (from RefSeq NM_001355460.1) ENSMUST00000106749.1 ENSMUST00000106749.2 ENSMUST00000106749.3 ENSMUST00000106749.4 ENSMUST00000106749.5 ENSMUST00000106749.6 ENSMUST00000106749.7 Hspb11 IFT25_MOUSE NM_001355460 Q3TZR2 Q9D6H2 uc008tzn.1 uc008tzn.2 uc008tzn.3 Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (PubMed:22595669). Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation (PubMed:28430876). Plays a role in the early development of the kidney (PubMed:29626631). May be involved in the regulation of ureteric bud initiation (PubMed:29626631). Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (PubMed:19253336). Interacts with IFT27 (PubMed:28430876). Interacts with IFT88 (PubMed:19253336). Cell projection, cilium Expressed predominantly in the testis (at protein level). Null mutants retain the ability to ciliate and survive through gestation. They die shortly after birth due to different phenotypes reminiscent of Shh signaling defects: polydactyly, cleft palate, lung isomerisms, and structural heart defects (PubMed:22595669). Conditional knockout in male germ cells results in infertility, abnormal sperm morphology, significantly reduced sperm count and sperm mobility and disruption of sperm lipid rafts (PubMed:28964737, PubMed:28430876). Mutant mice with germline deletion of IFT25 die shortly after birth with structural defects in most organs including the kidneys, where duplicated collecting duct system and/or duplex kidney is often observed (PubMed:29626631). Belongs to the IFT25 family. Was initially classified as a member of the small heat shock family protein. However, it was later shown that it is not the case (PubMed:22595669). skeletal system development kidney development protein binding centrosome cilium smoothened signaling pathway spermatogenesis heart development protein transport cell differentiation lung development intraciliary transport particle B intraciliary transport cell projection metal ion binding left/right axis specification cilium assembly uc008tzn.1 uc008tzn.2 uc008tzn.3 
ENSMUST00000106755.3 Ovch2 ENSMUST00000106755.3 ovochymase 2 (from RefSeq NM_172908.3) ENSMUST00000106755.1 ENSMUST00000106755.2 NM_172908 OVCH2_MOUSE Ovch2 Ovtn Q7M761 Q8BZQ8 uc009jbk.1 uc009jbk.2 uc009jbk.3 May be required for sperm ADAM3 processing and consequential sperm fertilizing ability (PubMed:32499443). In vitro, has an endopeptidase activity (By similarity). Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7M761-1; Sequence=Displayed; Name=2; IsoId=Q7M761-2; Sequence=VSP_021668; Only expressed in uterus tissue (PubMed:20810007). Expressed in the initial segment (IS) of the caput epididymis, the region most proximal to the testis (PubMed:32499443). Knockout male mice lacking OVCH2 are sterile. Belongs to the peptidase S1 family. serine-type endopeptidase activity cellular_component extracellular region proteolysis peptidase activity serine-type peptidase activity hydrolase activity metal ion binding uc009jbk.1 uc009jbk.2 uc009jbk.3 
ENSMUST00000106758.8 Cyb5rl ENSMUST00000106758.8 cytochrome b5 reductase-like, transcript variant 8 (from RefSeq NM_001377088.1) B1AS41 B1AS42 ENSMUST00000106758.1 ENSMUST00000106758.2 ENSMUST00000106758.3 ENSMUST00000106758.4 ENSMUST00000106758.5 ENSMUST00000106758.6 ENSMUST00000106758.7 NB5R5_MOUSE NM_001377088 Q571N5 Q80W48 Q99KB7 uc008tzd.1 uc008tzd.2 uc008tzd.3 uc008tzd.4 NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Reaction=2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+); Xref=Rhea:RHEA:46680, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.2.2; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=B1AS42-1; Sequence=Displayed; Name=2; IsoId=B1AS42-2; Sequence=VSP_033851; Name=3; IsoId=B1AS42-3; Sequence=VSP_033849, VSP_033850; Name=4; IsoId=B1AS42-4; Sequence=VSP_033848, VSP_033852, VSP_033853; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. Sequence=AAH04750.1; Type=Erroneous initiation; Evidence=; Sequence=BAD90340.1; Type=Erroneous initiation; Evidence=; cytochrome-b5 reductase activity, acting on NAD(P)H nucleus nucleoplasm oxidoreductase activity oxidation-reduction process uc008tzd.1 uc008tzd.2 uc008tzd.3 uc008tzd.4 
ENSMUST00000106763.8 Bptf ENSMUST00000106763.8 Bptf (from geneSymbol) A2A654 A2A654_MOUSE Bptf ENSMUST00000106763.1 ENSMUST00000106763.2 ENSMUST00000106763.3 ENSMUST00000106763.4 ENSMUST00000106763.5 ENSMUST00000106763.6 ENSMUST00000106763.7 GU189417 uc288dbx.1 uc288dbx.2 negative regulation of transcription from RNA polymerase II promoter nuclear chromatin embryonic placenta development nucleus nucleoplasm cytoplasm chromatin remodeling regulation of transcription from RNA polymerase II promoter brain development endoderm development transcription factor binding anterior/posterior pattern specification NURF complex dendrite neuron projection sequence-specific DNA binding cell body positive regulation of transcription from RNA polymerase II promoter metal ion binding perinuclear region of cytoplasm DNA-dependent ATPase activity uc288dbx.1 uc288dbx.2 
ENSMUST00000106767.3 1810010H24Rik ENSMUST00000106767.3 1810010H24Rik (from geneSymbol) 1810010H24Rik A0A1B0GT03 A0A1B0GT03_MOUSE AK007422 ENSMUST00000106767.1 ENSMUST00000106767.2 uc007mab.1 uc007mab.2 uc007mab.3 uc007mab.4 uc007mab.1 uc007mab.2 uc007mab.3 uc007mab.4 
ENSMUST00000106770.8 Mroh7 ENSMUST00000106770.8 maestro heat-like repeat family member 7 (from RefSeq NM_001126487.1) A2AVR2 ENSMUST00000106770.1 ENSMUST00000106770.2 ENSMUST00000106770.3 ENSMUST00000106770.4 ENSMUST00000106770.5 ENSMUST00000106770.6 ENSMUST00000106770.7 Gm1027 Heatr8 MROH7_MOUSE NM_001126487 uc012dia.1 uc012dia.2 Membrane ; Multi-pass membrane protein molecular_function biological_process membrane integral component of membrane uc012dia.1 uc012dia.2 
ENSMUST00000106783.8 Timm10b ENSMUST00000106783.8 Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. (from UniProt Q9WV96) BC009158 ENSMUST00000106783.1 ENSMUST00000106783.2 ENSMUST00000106783.3 ENSMUST00000106783.4 ENSMUST00000106783.5 ENSMUST00000106783.6 ENSMUST00000106783.7 Fxc1 Q545D2 Q9DCB5 Q9WV96 T10B_MOUSE Tim9b Timm9b uc009iyt.1 uc009iyt.2 uc009iyt.3 uc009iyt.4 Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. Component of the TIM22 complex, which core is composed of TIMM22, associated with TIMM10 (TIMM10A and/or TIMM10B), TIMM9, AGK and TIMM29. Mitochondrion inner membrane ; Peripheral membrane protein The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane. Belongs to the small Tim family. mitochondrion mitochondrial inner membrane protein transport membrane mitochondrial intermembrane space protein transporter complex mitochondrial inner membrane protein insertion complex metal ion binding uc009iyt.1 uc009iyt.2 uc009iyt.3 uc009iyt.4 
ENSMUST00000106796.9 Pecam1 ENSMUST00000106796.9 platelet/endothelial cell adhesion molecule 1, transcript variant 3 (from RefSeq NM_001305157.1) B1ARB1 B1ARB2 ENSMUST00000106796.1 ENSMUST00000106796.2 ENSMUST00000106796.3 ENSMUST00000106796.4 ENSMUST00000106796.5 ENSMUST00000106796.6 ENSMUST00000106796.7 ENSMUST00000106796.8 NM_001305157 PECA1_MOUSE Pecam Pecam-1 Q08481 Q3TES6 Q922E0 uc007lze.1 uc007lze.2 uc007lze.3 uc007lze.4 Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (By similarity). Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (By similarity). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (By similarity). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (By similarity). Homophilic ligation of PECAM1 prevents macrophage- mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (By similarity). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (By similarity). Modulates bradykinin receptor BDKRB2 activation (By similarity). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (By similarity). Induces susceptibility to atherosclerosis (PubMed:19048083). Trans-homodimer (via Ig-like C2-type 1 and Ig-like C2-type 2 domains); trans-homodimerization is required for cell-cell interaction. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ. Interacts with PTPN11; Tyr-702 is critical for PTPN11 recruitment. Interacts with FER. Interacts with CD177; the interaction is Ca(2+)- dependent; the interaction is direct. Cell membrane ; Single-pass type I membrane protein Membrane raft Cell junction Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q08481-1; Sequence=Displayed; Name=2; IsoId=Q08481-2; Sequence=VSP_038724; Name=3; IsoId=Q08481-3; Sequence=VSP_038725; Name=4; IsoId=Q08481-4; Sequence=VSP_038723; [Isoform 1]: Expressed in lung and platelets (at protein level). [Isoform 3]: Expressed in lung and platelets (at protein level). Expressed in the venous vessels of the heart and skin at 15.5 dpc. The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity. Phosphorylated on Ser and Tyr residues by src kinases after cellular activation (PubMed:16731527). Upon activation, phosphorylated on Ser-718 which probably initiates the dissociation of the membrane- interaction segment (residues 698-718) from the cell membrane allowing the sequential phosphorylation of Tyr-702 and Tyr-679 (By similarity). Constitutively phosphorylated on Ser-723 in resting platelets (By similarity). Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (PubMed:16731527). In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation (By similarity). Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts. Mice show reduced atherosclerotic lesions. There is down-regulation of ICAM-1 in endothelial cells at the lesion periphery, and reduced disruption of Cx43 junctional staining at arterial branch points and in the descending aorta. Name=Functional Glycomics Gateway - Glycan Binding; Note=PECAM-1; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Itlect_191"; angiogenesis ruffle endothelial cell morphogenesis positive regulation of protein phosphorylation positive regulation of leukocyte migration positive regulation of cellular extravasation protein binding extracellular space cytoplasm plasma membrane cell-cell junction phagocytosis cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules leukocyte cell-cell adhesion Rho protein signal transduction external side of plasma membrane cell surface membrane integral component of membrane protein phosphatase binding cell junction regulation of cell migration positive regulation of cell migration smooth muscle contractile fiber negative regulation of actin filament polymerization macromolecular complex negative regulation of GTPase activity monocyte extravasation wound healing positive regulation of tyrosine phosphorylation of STAT protein protein homodimerization activity endothelial cell migration cell-cell contact zone membrane raft positive regulation of peptidyl-tyrosine phosphorylation negative regulation of peptidyl-tyrosine phosphorylation diapedesis establishment of endothelial barrier bicellular tight junction assembly cell periphery glomerular endothelium development neutrophil extravasation endothelial cell-matrix adhesion cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules uc007lze.1 uc007lze.2 uc007lze.3 uc007lze.4 
ENSMUST00000106804.2 Fyb2 ENSMUST00000106804.2 FYN binding protein 2, transcript variant 4 (from RefSeq NR_104376.2) A2A995 ARAP ENSMUST00000106804.1 FYB2_MOUSE Fyb2 NR_104376 uc290ofj.1 uc290ofj.2 Adapter protein that plays a role in T-cell receptor (TCR)- mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation. Interacts with SKAP1, LCK and FYN. The phosphorylated form interacts with LCP2. Membrane raft Note=Recruited to membrane rafts and immunological synapse after TCR stimulation. Phosphorylation is required for its function in T-cell activation. immunological synapse molecular_function plasma membrane integrin-mediated signaling pathway membrane cell adhesion mediated by integrin membrane raft T cell receptor signaling pathway protein localization to plasma membrane uc290ofj.1 uc290ofj.2 
ENSMUST00000106805.4 Gm5901 ENSMUST00000106805.4 predicted gene 5901, transcript variant 3 (from RefSeq NM_001382419.1) D3YVJ1 D3YVJ1_MOUSE ENSMUST00000106805.1 ENSMUST00000106805.2 ENSMUST00000106805.3 Gm5901 NM_001382419 uc012frk.1 uc012frk.2 uc012frk.3 molecular_function cellular_component biological_process uc012frk.1 uc012frk.2 uc012frk.3 
ENSMUST00000106816.8 Prr29 ENSMUST00000106816.8 proline rich 29 (from RefSeq NM_029345.1) B1ARI9 ENSMUST00000106816.1 ENSMUST00000106816.2 ENSMUST00000106816.3 ENSMUST00000106816.4 ENSMUST00000106816.5 ENSMUST00000106816.6 ENSMUST00000106816.7 NM_029345 PRR29_MOUSE Q9D7I4 uc007lyw.1 uc007lyw.2 uc007lyw.3 uc007lyw.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B1ARI9-1; Sequence=Displayed; Name=2; IsoId=B1ARI9-2; Sequence=VSP_034786; molecular_function cellular_component biological_process uc007lyw.1 uc007lyw.2 uc007lyw.3 uc007lyw.4 
ENSMUST00000106828.3 Trim30c ENSMUST00000106828.3 tripartite motif-containing 30C, transcript variant 2 (from RefSeq NM_001378693.1) D3YVI9 D3YVI9_MOUSE ENSMUST00000106828.1 ENSMUST00000106828.2 NM_001378693 Trim30c uc291ttu.1 uc291ttu.2 molecular_function ubiquitin-protein transferase activity cellular_component autophagy biological_process zinc ion binding protein ubiquitination innate immune response metal ion binding defense response to virus uc291ttu.1 uc291ttu.2 
ENSMUST00000106830.9 Dab1 ENSMUST00000106830.9 disabled 1, transcript variant 3 (from RefSeq NR_104385.1) A2A963 A2A964 A2A965 A2A966 A2A967 A2A970 DAB1_MOUSE ENSMUST00000106830.1 ENSMUST00000106830.2 ENSMUST00000106830.3 ENSMUST00000106830.4 ENSMUST00000106830.5 ENSMUST00000106830.6 ENSMUST00000106830.7 ENSMUST00000106830.8 NR_104385 P97316 P97317 P97318 Q9DAP9 uc008txw.1 uc008txw.2 uc008txw.3 uc008txw.4 Adapter molecule functioning in neural development. May regulate SIAH1 activity. Associates with the SH2 domains of SRC, FYN and ABL. Interacts (phosphorylated on tyrosine residues) with CRK and CRKL (via respective SH2 domain) (PubMed:15062102). Interacts with SIAH1, LRP8 and VLDLR (PubMed:12646221, PubMed:12737822). Interacts with LRP1 (By similarity). Interacts with APLP1 (via NPXY motif) (PubMed:12826668). Interacts with DAB2IP (By similarity). P97318; Q03157: Aplp1; NbExp=4; IntAct=EBI-81680, EBI-399929; P97318; P12023: App; NbExp=3; IntAct=EBI-81680, EBI-78814; P97318; Q3UHC7: Dab2ip; NbExp=3; IntAct=EBI-81680, EBI-6306507; P97318; Q91ZX7: Lrp1; NbExp=2; IntAct=EBI-81680, EBI-300955; P97318; A2ARV4: Lrp2; NbExp=2; IntAct=EBI-81680, EBI-300875; P97318; Q8VHR0: Pcdh18; NbExp=2; IntAct=EBI-81680, EBI-399910; P97318; P61092: Siah1a; NbExp=3; IntAct=EBI-81680, EBI-446761; Event=Alternative splicing; Named isoforms=7; Name=DAB588; IsoId=P97318-1; Sequence=Displayed; Name=DAB197; IsoId=P97318-4; Sequence=VSP_026205, VSP_003841, VSP_003842; Name=DAB204; IsoId=P97318-5; Sequence=VSP_026208, VSP_026209; Name=DAB217; IsoId=P97318-6; Sequence=VSP_003841, VSP_003842; Name=DAB271; IsoId=P97318-3; Sequence=VSP_003843, VSP_003844, VSP_003845; Name=DAB553; IsoId=P97318-8; Sequence=VSP_026206; Name=DAB555; IsoId=P97318-2; Sequence=VSP_003843; Expressed mainly in brain. The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins. Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (PubMed:11279201). Also found phosphorylated on Tyr- 232 upon reelin induction (PubMed:15062102). Also phosphorylated on Ser-524 independently of reelin signaling. neuron migration protein binding phospholipid binding cytoplasm cytosol brush border negative regulation of cell adhesion small GTPase mediated signal transduction multicellular organism development nervous system development central nervous system development brain development midgut development adult walking behavior postsynaptic density membrane dendrite development ventral spinal cord development cerebellum structural organization hippocampus development cerebral cortex cell migration cerebral cortex radially oriented cell migration cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration radial glia guided migration of Purkinje cell cerebral cortex development cell differentiation intracellular signal transduction SH2 domain binding response to drug neuron projection neuronal cell body intracellular membrane-bounded organelle phosphatidylinositol 3-kinase binding apical part of cell positive regulation of neuron differentiation positive regulation of protein kinase activity negative regulation of JAK-STAT cascade negative regulation of astrocyte differentiation negative regulation of axonogenesis Golgi localization lateral motor column neuron migration perinuclear region of cytoplasm uc008txw.1 uc008txw.2 uc008txw.3 uc008txw.4 
ENSMUST00000106831.3 Trim30b ENSMUST00000106831.3 Cytoplasm (from UniProt D3YVI7) AK162946 D3YVI7 D3YVI7_MOUSE ENSMUST00000106831.1 ENSMUST00000106831.2 Trim30b uc057caq.1 uc057caq.2 uc057caq.3 Cytoplasm Belongs to the TRIM/RBCC family. molecular_function ubiquitin-protein transferase activity cellular_component autophagy biological_process zinc ion binding protein ubiquitination innate immune response metal ion binding defense response to virus uc057caq.1 uc057caq.2 uc057caq.3 
ENSMUST00000106839.9 Trim12a ENSMUST00000106839.9 tripartite motif-containing 12A, transcript variant 2 (from RefSeq NM_023835.2) A0A0R4J1B5 A0A0R4J1B5_MOUSE ENSMUST00000106839.1 ENSMUST00000106839.2 ENSMUST00000106839.3 ENSMUST00000106839.4 ENSMUST00000106839.5 ENSMUST00000106839.6 ENSMUST00000106839.7 ENSMUST00000106839.8 NM_023835 Trim12a uc009ivw.1 uc009ivw.2 uc009ivw.3 Cytoplasm Belongs to the TRIM/RBCC family. ubiquitin-protein transferase activity autophagy zinc ion binding protein ubiquitination innate immune response metal ion binding defense response to virus uc009ivw.1 uc009ivw.2 uc009ivw.3 
ENSMUST00000106847.9 Trim34b ENSMUST00000106847.9 tripartite motif-containing 34B (from RefSeq NM_001243916.1) ENSMUST00000106847.1 ENSMUST00000106847.2 ENSMUST00000106847.3 ENSMUST00000106847.4 ENSMUST00000106847.5 ENSMUST00000106847.6 ENSMUST00000106847.7 ENSMUST00000106847.8 K7N6K2 NM_001243916 TR34B_MOUSE Trim34b uc012frg.1 uc012frg.2 uc012frg.3 uc012frg.4 Functions as antiviral protein and contributes to the defense against retroviral infections (By similarity). Acts as a capsid- specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys- 63'-linked polyubiquitination. In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (By similarity). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis. Promotes also the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (By similarity). Regulates intestinal inflammation by controlling the exocytosis of the major component of colonic mucus MUC2 from colonic goblet cells (PubMed:32094504). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homotrimer. Interacts (via B-box and SPRY domain) with TRIM5. Cytoplasm Mitochondrion Trim34a- and TRIM34b-deficient mice show an impaired integrity of the inner mucus layer. Belongs to the TRIM/RBCC family. molecular_function cellular_component biological_process zinc ion binding metal ion binding uc012frg.1 uc012frg.2 uc012frg.3 uc012frg.4 
ENSMUST00000106849.9 Trim34a ENSMUST00000106849.9 tripartite motif-containing 34A, transcript variant 4 (from RefSeq NR_185321.1) E9PYZ4 ENSMUST00000106849.1 ENSMUST00000106849.2 ENSMUST00000106849.3 ENSMUST00000106849.4 ENSMUST00000106849.5 ENSMUST00000106849.6 ENSMUST00000106849.7 ENSMUST00000106849.8 F8VPK2 NR_185321 Q99PP4 Q99PP5 Q99PP6 TR34A_MOUSE Trim34a uc009ivr.1 uc009ivr.2 uc009ivr.3 uc009ivr.4 Functions as antiviral protein and contributes to the defense against retroviral infections (By similarity). Acts as a capsid- specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys- 63'-linked polyubiquitination. In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (By similarity). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis. Promotes also the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (By similarity). Plays an essential role in sustaining the integrity of the inner mucus layer in the colon by controlling the exocytosis of the major component of colonic mucus MUC2 from colonic goblet cells (PubMed:32094504). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homotrimer. Interacts (via B-box and SPRY domain) with TRIM5. Cytoplasm Mitochondrion Event=Alternative splicing; Named isoforms=3; Name=Alpha; IsoId=Q99PP6-1; Sequence=Displayed; Name=Beta; IsoId=Q99PP6-2; Sequence=VSP_011923, VSP_011924; Name=Gamma; IsoId=Q99PP6-3; Sequence=VSP_011925, VSP_011926; Trim34a- and TRIM34b-deficient mice show an impaired integrity of the inner mucus layer. Belongs to the TRIM/RBCC family. cytoplasm zinc ion binding metal ion binding defense response to virus uc009ivr.1 uc009ivr.2 uc009ivr.3 uc009ivr.4 
ENSMUST00000106858.8 Mier1 ENSMUST00000106858.8 MEIR1 treanscription regulator, transcript variant 1 (from RefSeq NM_027696.4) A1L3P9 B1AY29 B1AY34 ENSMUST00000106858.1 ENSMUST00000106858.2 ENSMUST00000106858.3 ENSMUST00000106858.4 ENSMUST00000106858.5 ENSMUST00000106858.6 ENSMUST00000106858.7 Kiaa1610 MIER1_MOUSE NM_027696 Q5UAK0 Q5UAK1 Q5UAK2 Q5UAK3 Q6ZPL6 Q9D402 uc008txe.1 uc008txe.2 uc008txe.3 uc008txe.4 Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. Interacts with HDAC1. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. Nucleus Event=Alternative splicing; Named isoforms=5; Name=3; Synonyms=N3 beta; IsoId=Q5UAK0-3; Sequence=Displayed; Name=1; Synonyms=N4 beta; IsoId=Q5UAK0-1; Sequence=VSP_042454; Name=2; Synonyms=N1 beta; IsoId=Q5UAK0-2; Sequence=VSP_016175; Name=4; Synonyms=N2 beta; IsoId=Q5UAK0-4; Sequence=VSP_016177; Name=5; IsoId=Q5UAK0-5; Sequence=VSP_016174; Ubiquitously expressed. Isoform 1 is only expressed in testis. Sequence=BAC98215.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding DNA binding transcription corepressor activity histone deacetylase activity nucleus nucleoplasm regulation of transcription, DNA-templated histone deacetylation transcriptional repressor complex positive regulation of chromatin silencing macromolecular complex histone deacetylase binding uc008txe.1 uc008txe.2 uc008txe.3 uc008txe.4 
ENSMUST00000106859.3 Or52h2 ENSMUST00000106859.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGW1) ENSMUST00000106859.1 ENSMUST00000106859.2 Olfr649 Or52h2 Q8VGW1 Q8VGW1_MOUSE uc291ttc.1 uc291ttc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ttc.1 uc291ttc.2 
ENSMUST00000106863.2 Or51m1 ENSMUST00000106863.2 olfactory receptor family 51 subfamily M member 1 (from RefSeq NM_001271020.1) ENSMUST00000106863.1 F8VPJ9 F8VPJ9_MOUSE NM_001271020 Olfr631 Or51m1 uc033jbd.1 uc033jbd.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033jbd.1 uc033jbd.2 
ENSMUST00000106866.3 Hbb-bh2 ENSMUST00000106866.3 hemoglobin beta, bh2 (from RefSeq NM_001127686.1) B2RVB7 B2RVB7_MOUSE EG436003 ENSMUST00000106866.1 ENSMUST00000106866.2 Glnb2 Gm5736 Hbb-bh2 NM_001127686 uc012frd.1 uc012frd.2 uc012frd.3 Involved in oxygen transport from the lung to the various peripheral tissues. Belongs to the globin family. Lacks conserved residue(s) required for the propagation of feature annotation. oxygen transporter activity hemoglobin complex oxygen transport oxygen binding heme binding hemoglobin alpha binding haptoglobin-hemoglobin complex hydrogen peroxide catabolic process organic acid binding metal ion binding cellular oxidant detoxification peroxidase activity haptoglobin binding uc012frd.1 uc012frd.2 uc012frd.3 
ENSMUST00000106868.4 Dnai4 ENSMUST00000106868.4 dynein axonemal intermediate chain 4, transcript variant 1 (from RefSeq NM_146254.5) DNAI4_MOUSE E9PYY5 ENSMUST00000106868.1 ENSMUST00000106868.2 ENSMUST00000106868.3 NM_146254 Q8C0I9 Q8K042 Q8K111 Wdr78 uc029uyj.1 uc029uyj.2 uc029uyj.3 Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility. Part of the multisubunit axonemal dynein complex formed at least of two heavy chains and a number of intermediate and light chains. Associated with axonemal dynein subunits such as, DNAH2, DNAI3, and DYNLT1 (PubMed:30060180). Interacts with DYNLT1 (PubMed:30060180). Cytoplasm, cytoskeleton, flagellum axoneme Cytoplasm, cytoskeleton, cilium axoneme Dynein axonemal particle Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=E9PYY5-1; Sequence=Displayed; Name=2; IsoId=E9PYY5-2; Sequence=VSP_042401, VSP_042402; Name=3; IsoId=E9PYY5-3; Sequence=VSP_042399, VSP_042400, VSP_042403; Name=4; IsoId=E9PYY5-4; Sequence=VSP_042399, VSP_042403; Highly expressed in tissues containing motile cilia, including the trachea, lung, oviduct, and testis. hematopoietic progenitor cell differentiation cilium movement axonemal dynein complex microtubule-based movement dynein light chain binding dynein heavy chain binding ATP-dependent microtubule motor activity, plus-end-directed uc029uyj.1 uc029uyj.2 uc029uyj.3 
ENSMUST00000106878.3 Or52a5b ENSMUST00000106878.3 olfactory receptor family 52 subfamily A member 5B (from RefSeq NM_013621.3) E9Q7C5 E9Q7C5_MOUSE ENSMUST00000106878.1 ENSMUST00000106878.2 NM_013621 Olfr69 Or52a5b uc009ium.1 uc009ium.2 uc009ium.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ium.1 uc009ium.2 uc009ium.3 
ENSMUST00000106880.3 Or51l4 ENSMUST00000106880.3 olfactory receptor family 51 subfamily L member 4 (from RefSeq NM_147098.2) ENSMUST00000106880.1 ENSMUST00000106880.2 NM_147098 Olfr630 Or51l4 Q9EQQ7 Q9EQQ7_MOUSE uc009iul.1 uc009iul.2 uc009iul.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## CDS exon combination :: BC116998.1 [ECO:0000331] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009iul.1 uc009iul.2 uc009iul.3 
ENSMUST00000106892.2 Usp17lc ENSMUST00000106892.2 Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes (PubMed:8995226, PubMed:11443643). Important for preimplantation stage embryonic development (PubMed:22984479). (from UniProt G5E8I7) BC152899 DUB-2 Dub2 ENSMUST00000106892.1 G5E8I7 O55190 O55191 U17LC_MOUSE Usp17l5 Usp17lc uc291tqg.1 uc291tqg.2 Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes (PubMed:8995226, PubMed:11443643). Important for preimplantation stage embryonic development (PubMed:22984479). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence= Nucleus Endoplasmic reticulum Expressed in T cells. Rapidly up-regulated in response to the cytokine IL2. Embryonic lethal, with no survival beyond embryonic stage E5.5. Blastocysts fail to hatch and there is significant apoptosis of the trophectoderm. Cell proliferation may also be impaired. Blastocysts at stage E3.5 appear to have normal morphology. Belongs to the peptidase C19 family. USP17 subfamily. cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus endoplasmic reticulum proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity regulation of apoptotic process chordate embryonic development uc291tqg.1 uc291tqg.2 
ENSMUST00000106893.3 Or52j3 ENSMUST00000106893.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PYB3) E9PYB3 E9PYB3_MOUSE ENSMUST00000106893.1 ENSMUST00000106893.2 Olfr592 Or52j3 uc291tpn.1 uc291tpn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tpn.1 uc291tpn.2 
ENSMUST00000106899.4 Cxcr2 ENSMUST00000106899.4 C-X-C motif chemokine receptor 2 (from RefSeq NM_009909.3) CXCR2_MOUSE Cmkar2 ENSMUST00000106899.1 ENSMUST00000106899.2 ENSMUST00000106899.3 Gpcr16 Il8rb NM_009909 P35343 Q53X27 uc007bll.1 uc007bll.2 uc007bll.3 Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Interacts with IL8. Interacts with GNAI2. Cell membrane; Multi-pass membrane protein. Phosphorylated upon ligand binding; which is required for desensitization. Belongs to the G-protein coupled receptor 1 family. acute inflammatory response to antigenic stimulus positive regulation of leukocyte chemotaxis interleukin-8 receptor activity G-protein coupled receptor activity chemokine receptor activity protein binding plasma membrane chemotaxis immune response cellular defense response signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of cell proliferation external side of plasma membrane cell surface positive regulation of cardiac muscle cell apoptotic process membrane integral component of membrane C-C chemokine receptor activity C-X-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding interleukin-8 binding neutrophil chemotaxis midbrain development receptor internalization negative regulation of neutrophil apoptotic process interleukin-8-mediated signaling pathway neutrophil activation mast cell granule negative regulation of apoptotic process positive regulation of vascular permeability positive regulation of angiogenesis cell chemotaxis chemokine-mediated signaling pathway metanephric tubule morphogenesis positive regulation of neutrophil chemotaxis uc007bll.1 uc007bll.2 uc007bll.3 
ENSMUST00000106911.8 Pde4b ENSMUST00000106911.8 phosphodiesterase 4B, cAMP specific, transcript variant 7 (from RefSeq NM_001404786.1) B1AWC9 B1AWC9_MOUSE ENSMUST00000106911.1 ENSMUST00000106911.2 ENSMUST00000106911.3 ENSMUST00000106911.4 ENSMUST00000106911.5 ENSMUST00000106911.6 ENSMUST00000106911.7 NM_001404786 Pde4b uc290ocx.1 uc290ocx.2 Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. gamma-tubulin complex neutrophil homeostasis 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding nucleus cytoplasm centrosome cytosol voltage-gated calcium channel complex signal transduction synaptic vesicle phosphoric diester hydrolase activity response to heat postsynaptic density membrane hydrolase activity Z disc cAMP binding neutrophil chemotaxis positive regulation of interferon-gamma production positive regulation of interleukin-2 production cellular response to drug gamma-tubulin binding dendritic spine ion channel binding metal ion binding perinuclear region of cytoplasm T cell receptor signaling pathway leukocyte migration excitatory synapse cellular response to lipopolysaccharide cellular response to epinephrine stimulus cell periphery regulation of cardiac muscle cell contraction regulation of high voltage-gated calcium channel activity negative regulation of relaxation of cardiac muscle smooth muscle contraction uc290ocx.1 uc290ocx.2 
ENSMUST00000106914.8 Prame62 ENSMUST00000106914.8 predicted gene 12789 (from RefSeq NM_001085520.2) B1AUV7 B1AUV7_MOUSE ENSMUST00000106914.1 ENSMUST00000106914.2 ENSMUST00000106914.3 ENSMUST00000106914.4 ENSMUST00000106914.5 ENSMUST00000106914.6 ENSMUST00000106914.7 Gm12789 NM_001085520 uc008twh.1 uc008twh.2 uc008twh.3 uc008twh.4 molecular_function cytoplasm biological_process uc008twh.1 uc008twh.2 uc008twh.3 uc008twh.4 
ENSMUST00000106916.2 Gm12790 ENSMUST00000106916.2 predicted gene 12790 (from RefSeq NM_001377350.1) B1AUV6 B1AUV6_MOUSE ENSMUST00000106916.1 Gm12790 NM_001377350 uc290oct.1 uc290oct.2 molecular_function cytoplasm biological_process uc290oct.1 uc290oct.2 
ENSMUST00000106919.8 Pramel17 ENSMUST00000106919.8 PRAME like 17 (from RefSeq NM_001033790.3) B020004J07Rik ENSMUST00000106919.1 ENSMUST00000106919.2 ENSMUST00000106919.3 ENSMUST00000106919.4 ENSMUST00000106919.5 ENSMUST00000106919.6 ENSMUST00000106919.7 NM_001033790 Pramel17 Q3UTC0 Q3UTC0_MOUSE uc008twc.1 uc008twc.2 uc008twc.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008twc.1 uc008twc.2 uc008twc.3 
ENSMUST00000106928.10 Slc22a15 ENSMUST00000106928.10 solute carrier family 22 (organic anion/cation transporter), member 15 (from RefSeq NM_001039371.2) A7MCW2 ENSMUST00000106928.1 ENSMUST00000106928.2 ENSMUST00000106928.3 ENSMUST00000106928.4 ENSMUST00000106928.5 ENSMUST00000106928.6 ENSMUST00000106928.7 ENSMUST00000106928.8 ENSMUST00000106928.9 F8WJ00 NM_001039371 Q504N2 Q8CDR3 S22AF_MOUSE Slc22a15 uc008qrl.1 uc008qrl.2 uc008qrl.3 uc008qrl.4 uc008qrl.5 Organic zwitterion/cation transporter with apparent specificity for amino acids and their derivatives. Substrate selectivity and the transport mechanism, symport with sodium or facilitated diffusion allosterically regulated by sodium, remain to be elucidated. Reaction=ergothioneine(in) = ergothioneine(out); Xref=Rhea:RHEA:76263, ChEBI:CHEBI:134344; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:76265; Evidence=; Reaction=creatine(in) = creatine(out); Xref=Rhea:RHEA:73043, ChEBI:CHEBI:57947; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:73045; Evidence=; Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q504N2-1; Sequence=Displayed; Name=3; IsoId=Q504N2-3; Sequence=VSP_034061, VSP_034064; N-glycosylated. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. Contrary to human ortholog, the transport of carnitine and carnosine could not be detected. ion transport membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008qrl.1 uc008qrl.2 uc008qrl.3 uc008qrl.4 uc008qrl.5 
ENSMUST00000106933.2 Dnajc6 ENSMUST00000106933.2 DnaJ heat shock protein family (Hsp40) member C6, transcript variant 1 (from RefSeq NM_001164583.2) AUXI_MOUSE B1B0B9 Dnajc6 ENSMUST00000106933.1 Kiaa0473 NM_001164583 Q6P2K9 Q80TZ3 Q8C7L9 uc290oci.1 uc290oci.2 Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin- mediated endocytosis in neurons. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Interacts with HSPA8/HSC70. Interacts with CLTC. Interacts with AP2A2 (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80TZ3-1; Sequence=Displayed; Name=2; IsoId=Q80TZ3-2; Sequence=VSP_019582; Name=3; IsoId=Q80TZ3-3; Sequence=VSP_019583; Mice have a high rate of early postnatal mortality, although surviving pups have a normal life span despite decreased body weight. Knockout animals have impaired synaptic vesicle recycling, with an increased number of clathrin-coated vesicles, and impaired clathrin-mediated endocytosis of synaptic vesicles in neuronal culture. There is an up-regulation of Gak, but this does not fully compensate for the lack of the protein. The brains from mutant mice do not display alterations in substantia nigra morphology or dopamine transporter abundance or distribution, in agreement with the lack of gait or movement abnormalities in the mutant animals. Sequence=AAH60734.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytoplasm protein dephosphorylation receptor-mediated endocytosis postsynaptic density synaptic vesicle uncoating hydrolase activity SH3 domain binding clathrin binding vesicle peptidyl-tyrosine dephosphorylation intracellular membrane-bounded organelle synapse clathrin coat disassembly clathrin-dependent endocytosis presynapse regulation of clathrin-dependent endocytosis uc290oci.1 uc290oci.2 
ENSMUST00000106941.9 Tlk2 ENSMUST00000106941.9 tousled-like kinase 2 (Arabidopsis), transcript variant A (from RefSeq NM_001112705.2) B1ASU9 B1ASU9_MOUSE ENSMUST00000106941.1 ENSMUST00000106941.2 ENSMUST00000106941.3 ENSMUST00000106941.4 ENSMUST00000106941.5 ENSMUST00000106941.6 ENSMUST00000106941.7 ENSMUST00000106941.8 NM_001112705 Tlk2 uc007lxf.1 uc007lxf.2 uc007lxf.3 uc007lxf.4 uc007lxf.5 regulation of chromatin assembly or disassembly protein kinase activity protein serine/threonine kinase activity ATP binding nucleus intermediate filament protein phosphorylation cellular response to DNA damage stimulus chromosome segregation peptidyl-serine phosphorylation negative regulation of proteasomal ubiquitin-dependent protein catabolic process intracellular signal transduction perinuclear region of cytoplasm cellular response to gamma radiation uc007lxf.1 uc007lxf.2 uc007lxf.3 uc007lxf.4 uc007lxf.5 
ENSMUST00000106950.8 Xndc1 ENSMUST00000106950.8 Xrcc1 N-terminal domain containing 1, transcript variant 2 (from RefSeq NM_001286690.1) E9PVR2 E9PVR2_MOUSE ENSMUST00000106950.1 ENSMUST00000106950.2 ENSMUST00000106950.3 ENSMUST00000106950.4 ENSMUST00000106950.5 ENSMUST00000106950.6 ENSMUST00000106950.7 NM_001286690 Xndc1 Xntrpc uc009iqk.1 uc009iqk.2 uc009iqk.3 uc009iqk.4 single strand break repair molecular_function damaged DNA binding cellular_component nucleus integral component of plasma membrane manganese ion transport single fertilization biological_process store-operated calcium channel activity cation channel complex regulation of cytosolic calcium ion concentration calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding uc009iqk.1 uc009iqk.2 uc009iqk.3 uc009iqk.4 
ENSMUST00000106955.2 Raver2 ENSMUST00000106955.2 Raver2 (from geneSymbol) AK040404 B1ASP0 B1ASP0_MOUSE ENSMUST00000106955.1 Raver2 uc008tvi.1 uc008tvi.2 uc008tvi.3 nucleic acid binding RNA binding uc008tvi.1 uc008tvi.2 uc008tvi.3 
ENSMUST00000106966.8 Lrrc51 ENSMUST00000106966.8 leucine rich repeat containing 51, transcript variant 2 (from RefSeq NM_001162973.1) ENSMUST00000106966.1 ENSMUST00000106966.2 ENSMUST00000106966.3 ENSMUST00000106966.4 ENSMUST00000106966.5 ENSMUST00000106966.6 ENSMUST00000106966.7 G5E8I1 G5E8I1_MOUSE Lrrc51 NM_001162973 uc012fqq.1 uc012fqq.2 uc012fqq.3 Cytoplasm uc012fqq.1 uc012fqq.2 uc012fqq.3 
ENSMUST00000106970.3 Tomt ENSMUST00000106970.3 transmembrane O-methyltransferase, transcript variant 1 (from RefSeq NM_001081679.1) A1Y9I9 Comt2 ENSMUST00000106970.1 ENSMUST00000106970.2 NM_001081679 TOMT_MOUSE Tomt uc009ipv.1 uc009ipv.2 uc009ipv.3 Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (PubMed:18794526). Required for auditory function (PubMed:18794526, PubMed:28504928). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (PubMed:28504928). Reaction=a catechol + S-adenosyl-L-methionine = a guaiacol + H(+) + S- adenosyl-L-homocysteine; Xref=Rhea:RHEA:17877, ChEBI:CHEBI:15378, ChEBI:CHEBI:33566, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:134251; EC=2.1.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17878; Evidence=; Interacts with LHFPL5, PCDH15, TMC1, TMC2 and TMIE (PubMed:28504928). The interaction of TOMT with TMC1 and TMC2 is required for the transportation of TMC1/2 into the stereocilia of hair cells (PubMed:28504928, PubMed:28534737). Interacts directly with TMC1 (PubMed:28534737). Cytoplasm doplasmic reticulum Note=Localized to the cell body of the cochlear hair cells, but is not present in the stereocilia. Present but not restricted to the apical cistern, Hensen's body and the subsurface cistern. Widely expressed with high levels in outer and inner hair cells of the cochlea and vestibule. Not detected in the embryo at 12.5 dpc. At 14.5 dpc, expressed in the developing inner ear. At 16.5 dpc, expressed in the utricle and saccule. At 18.5 dpc, expressed specifically in the region of the sensory cells of the cochlea, utricle, saccule and crista ampullaris. Absence of auditory brain stem response (ABR) to click stimuli demonstrates that the mice are profoundly deaf. Normal hair bundle morphology as at postnatal day (P) 5 the sensory epithelia are patterned into three rows of outer hair cells (OHCs) and one row of inner hair cells (IHCs). The bundles of OHCs appear similar in size to those of wild-type mice and form a normal staircase pattern. Hair cells are maintained in the presence of gentamicin, an aminoglycoside antibiotic that enters hair cells through their transduction channels and normally causes hair cell death. No difference in the expression or localization of tip link proteins CDH23 and PCDH15 or ATP2B2, MYO7A, ESPN and WHRN proteins at P5-P8 in hair bundles of hair cells. Normal localization of LHFPL5 and TMIE in OHCs, but TMC1 and TMC2 are absent from the hair bundles of OHCs. Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. Despite its name, the murine TOMT protein does not contain a transmembrane region in contrast to primate orthologs. protein binding cytoplasm endoplasmic reticulum catecholamine metabolic process sensory perception of sound methyltransferase activity O-methyltransferase activity catechol O-methyltransferase activity transferase activity methylation developmental process neurotransmitter catabolic process dopamine metabolic process catecholamine catabolic process apical part of cell auditory receptor cell development positive regulation of protein import uc009ipv.1 uc009ipv.2 uc009ipv.3 
ENSMUST00000106972.8 Kansl1 ENSMUST00000106972.8 KAT8 regulatory NSL complex subunit 1, transcript variant 4 (from RefSeq NM_001372459.1) 1700081L11Rik A2A5Y4 A2A5Y4_MOUSE ENSMUST00000106972.1 ENSMUST00000106972.2 ENSMUST00000106972.3 ENSMUST00000106972.4 ENSMUST00000106972.5 ENSMUST00000106972.6 ENSMUST00000106972.7 Kansl1 NM_001372459 uc007lwl.1 uc007lwl.2 uc007lwl.3 histone acetyltransferase complex uc007lwl.1 uc007lwl.2 uc007lwl.3 
ENSMUST00000106980.9 Trim45 ENSMUST00000106980.9 tripartite motif-containing 45, transcript variant 3 (from RefSeq NM_001165952.1) E9Q2K9 ENSMUST00000106980.1 ENSMUST00000106980.2 ENSMUST00000106980.3 ENSMUST00000106980.4 ENSMUST00000106980.5 ENSMUST00000106980.6 ENSMUST00000106980.7 ENSMUST00000106980.8 NM_001165952 Q3U5H4 Q6PFY8 Q8BVT5 TRI45_MOUSE uc008qra.1 uc008qra.2 uc008qra.3 uc008qra.4 E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779). Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response. May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PFY8-1; Sequence=Displayed; Name=2; IsoId=Q6PFY8-2; Sequence=VSP_012001; Deletion mutant mice show earlier onset of death and exhibit higher mortality in response to lethal challenge with LPS. The production of TNF-alpha, IL-6, and IL-1beta is also significantly up-regulated after TLR challenge. Belongs to the TRIM/RBCC family. nucleus nucleoplasm cytoplasm cytosol zinc ion binding intercellular bridge metal ion binding bone development uc008qra.1 uc008qra.2 uc008qra.3 uc008qra.4 
ENSMUST00000106983.8 Folr1 ENSMUST00000106983.8 folate receptor alpha, transcript variant 10 (from RefSeq NM_001412433.1) ENSMUST00000106983.1 ENSMUST00000106983.2 ENSMUST00000106983.3 ENSMUST00000106983.4 ENSMUST00000106983.5 ENSMUST00000106983.6 ENSMUST00000106983.7 FOLR1_MOUSE Fbp1 Folbp1 NM_001412433 P35846 Q9R222 uc029wnj.1 uc029wnj.2 Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:1894617). Has high affinity for folate and folic acid analogs at neutral pH (By similarity). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity). Required for normal embryonic development and normal cell proliferation (PubMed:10508523, PubMed:12854656, PubMed:15259034, PubMed:17286298). Required for renal folate reabsorption (PubMed:15703271). Cell membrane ; Lipid-anchor, GPI-anchor Apical cell membrane ; Lipid-anchor, GPI-anchor Basolateral cell membrane ; Lipid-anchor, GPI-like-anchor Secreted Cytoplasmic vesicle Cytoplasmic vesicle, clathrin-coated vesicle Endosome Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. Detected in kidney proximal tubules (at protein level). The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. Embryonic lethality at about 10.5 dpc, due to gross developmental defects, including defects of neural tube closure, craniofacial defects and defects in heart development. Embryos can be rescued by maternal folate supplementation. Belongs to the folate receptor family. heart looping neural crest cell migration involved in heart formation cardiac neural crest cell migration involved in outflow tract morphogenesis folic acid binding extracellular region nucleus endosome plasma membrane brush border posttranslational protein targeting to membrane drug binding folic acid transport membrane basolateral plasma membrane apical plasma membrane regulation of transforming growth factor beta receptor signaling pathway clathrin-coated vesicle axon regeneration anchored component of membrane anchored component of external side of plasma membrane cytoplasmic vesicle brush border membrane signaling receptor activity folic acid metabolic process anchored component of plasma membrane response to axon injury methotrexate binding regulation of canonical Wnt signaling pathway pharyngeal arch artery morphogenesis anterior neural tube closure folic acid receptor activity cellular response to folic acid folic acid import into cell uc029wnj.1 uc029wnj.2 
ENSMUST00000107016.10 Hsd3b1 ENSMUST00000107016.10 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1, transcript variant 1 (from RefSeq NM_008293.4) A2AEP8 ENSMUST00000107016.1 ENSMUST00000107016.2 ENSMUST00000107016.3 ENSMUST00000107016.4 ENSMUST00000107016.5 ENSMUST00000107016.6 ENSMUST00000107016.7 ENSMUST00000107016.8 ENSMUST00000107016.9 Hsd3b1 NM_008293 Q3UI20 Q3UI20_MOUSE uc008qqh.1 uc008qqh.2 uc008qqh.3 Belongs to the 3-beta-HSD family. 3-beta-hydroxy-delta5-steroid dehydrogenase activity steroid biosynthetic process oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidation-reduction process uc008qqh.1 uc008qqh.2 uc008qqh.3 
ENSMUST00000107019.8 Hsd3b3 ENSMUST00000107019.8 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3, transcript variant 2 (from RefSeq NM_001161743.1) 3BHS3_MOUSE ENSMUST00000107019.1 ENSMUST00000107019.2 ENSMUST00000107019.3 ENSMUST00000107019.4 ENSMUST00000107019.5 ENSMUST00000107019.6 ENSMUST00000107019.7 NM_001161743 P26150 uc290hyz.1 uc290hyz.2 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Reaction=a 3beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)- steroid + H(+) + NADH; Xref=Rhea:RHEA:24076, ChEBI:CHEBI:1722, ChEBI:CHEBI:15378, ChEBI:CHEBI:47907, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.145; Reaction=a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid; Xref=Rhea:RHEA:14709, ChEBI:CHEBI:47907, ChEBI:CHEBI:47909; EC=5.3.3.1; Lipid metabolism; steroid biosynthesis. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Liver and kidney. Greater expression in liver. Belongs to the 3-beta-HSD family. catalytic activity 3-beta-hydroxy-delta5-steroid dehydrogenase activity steroid delta-isomerase activity mitochondrion mitochondrial inner membrane mitochondrial intermembrane space endoplasmic reticulum endoplasmic reticulum membrane steroid biosynthetic process metabolic process C21-steroid hormone metabolic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor isomerase activity hippocampus development mitochondrial membrane intracellular membrane-bounded organelle response to corticosterone oxidation-reduction process uc290hyz.1 uc290hyz.2 
ENSMUST00000107022.8 Hsd3b2 ENSMUST00000107022.8 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. (from UniProt P26149) 3BHS2_MOUSE B1ARN7 BC040397 ENSMUST00000107022.1 ENSMUST00000107022.2 ENSMUST00000107022.3 ENSMUST00000107022.4 ENSMUST00000107022.5 ENSMUST00000107022.6 ENSMUST00000107022.7 Hsd3b2 P26149 Q8R0J6 uc008qqc.1 uc008qqc.2 uc008qqc.3 uc008qqc.4 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Reaction=a 3beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)- steroid + H(+) + NADH; Xref=Rhea:RHEA:24076, ChEBI:CHEBI:1722, ChEBI:CHEBI:15378, ChEBI:CHEBI:47907, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.145; Evidence=; Reaction=a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid; Xref=Rhea:RHEA:14709, ChEBI:CHEBI:47907, ChEBI:CHEBI:47909; EC=5.3.3.1; Evidence=; Reaction=NAD(+) + pregnenolone = H(+) + NADH + pregn-5-ene-3,20-dione; Xref=Rhea:RHEA:43924, ChEBI:CHEBI:15378, ChEBI:CHEBI:16581, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:63837; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43925; Evidence=; Reaction=pregn-5-ene-3,20-dione = progesterone; Xref=Rhea:RHEA:43928, ChEBI:CHEBI:17026, ChEBI:CHEBI:63837; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43929; Evidence=; Reaction=3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene- 3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:43932, ChEBI:CHEBI:15378, ChEBI:CHEBI:28689, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83865; EC=1.1.1.145; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43933; Evidence=; Reaction=androst-5-ene-3,17-dione = androst-4-ene-3,17-dione; Xref=Rhea:RHEA:43936, ChEBI:CHEBI:16422, ChEBI:CHEBI:83865; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43937; Evidence=; Lipid metabolism; steroid biosynthesis. Endoplasmic reticulum membrane ; Single-pass membrane protein Mitochondrion membrane ; Single-pass membrane protein Liver and kidney. Belongs to the 3-beta-HSD family. catalytic activity 3-beta-hydroxy-delta5-steroid dehydrogenase activity steroid delta-isomerase activity mitochondrion mitochondrial inner membrane mitochondrial intermembrane space endoplasmic reticulum endoplasmic reticulum membrane steroid biosynthetic process metabolic process C21-steroid hormone metabolic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor isomerase activity hippocampus development mitochondrial membrane intracellular membrane-bounded organelle response to corticosterone oxidation-reduction process uc008qqc.1 uc008qqc.2 uc008qqc.3 uc008qqc.4 
ENSMUST00000107032.3 Arhgef17 ENSMUST00000107032.3 Rho guanine nucleotide exchange factor 17 (from RefSeq NM_001081116.1) ARHGH_MOUSE ENSMUST00000107032.1 ENSMUST00000107032.2 Kiaa0337 NM_001081116 Q80U35 Q8BZY4 uc009inv.1 uc009inv.2 uc009inv.3 Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80U35-1; Sequence=Displayed; Name=2; IsoId=Q80U35-2; Sequence=VSP_025104, VSP_025105; Sequence=BAC65532.1; Type=Erroneous initiation; Evidence=; guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity actin cytoskeleton organization regulation of Rho protein signal transduction uc009inv.1 uc009inv.2 uc009inv.3 
ENSMUST00000107040.10 Acbd4 ENSMUST00000107040.10 Acbd4 (from geneSymbol) A2AHR2 A2AHR2_MOUSE AK079604 Acbd4 ENSMUST00000107040.1 ENSMUST00000107040.2 ENSMUST00000107040.3 ENSMUST00000107040.4 ENSMUST00000107040.5 ENSMUST00000107040.6 ENSMUST00000107040.7 ENSMUST00000107040.8 ENSMUST00000107040.9 uc007lti.1 uc007lti.2 uc007lti.3 molecular_function cellular_component biological_process membrane integral component of membrane uc007lti.1 uc007lti.2 uc007lti.3 
ENSMUST00000107044.10 Plekhb1 ENSMUST00000107044.10 pleckstrin homology domain containing, family B (evectins) member 1, transcript variant 5 (from RefSeq NM_001163185.1) ENSMUST00000107044.1 ENSMUST00000107044.2 ENSMUST00000107044.3 ENSMUST00000107044.4 ENSMUST00000107044.5 ENSMUST00000107044.6 ENSMUST00000107044.7 ENSMUST00000107044.8 ENSMUST00000107044.9 Evt1 NM_001163185 PKHB1_MOUSE Phr1 Q9QYB3 Q9QYB4 Q9QYD2 Q9QYD3 Q9QYE9 uc009inm.1 uc009inm.2 uc009inm.3 uc009inm.4 Binds transducins (By similarity). Homodimer. Interacts (via PH domain) with MYO1C. Interacts (via PH domain) with MYO7A. Q9QYE9-1; Q9WTI7: Myo1c; NbExp=4; IntAct=EBI-1127141, EBI-777558; Q9QYE9-2; Q9WTI7: Myo1c; NbExp=2; IntAct=EBI-1127145, EBI-777558; Membrane Cytoplasm Note=Membrane-associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones (By similarity). Localizes to the apical juxta-nuclear Golgi region of the cytoplasm (PubMed:20301200). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9QYE9-1; Sequence=Displayed; Name=2; IsoId=Q9QYE9-2; Sequence=VSP_009782; Name=3; IsoId=Q9QYE9-3; Sequence=VSP_009781; Name=4; IsoId=Q9QYE9-4; Sequence=VSP_009781, VSP_009782; Highly expressed in retina and brain. In retina, abundantly expressed in photoreceptors. Isoform 4 is the predominant isoform expressed in mature olfactory receptor neurons and vestibular and cochlear hair cells. Also expressed in cells with possible sensory function, including peripheral retinal ganglion cells, cochlear interdental cells, and neurons of the circumventricular organ (at protein level). Mice appear normal at birth with no obvious behavioral or growth abnormalities nor overt sensory deficits. At 6 months and 1 year of age, mice display normal retinal histology and normal response in electroretinograms. photoreceptor outer segment protein binding cytoplasm multicellular organism development protein C-terminus binding membrane integral component of membrane protein homodimerization activity regulation of cell differentiation uc009inm.1 uc009inm.2 uc009inm.3 uc009inm.4 
ENSMUST00000107050.8 Fmo5 ENSMUST00000107050.8 flavin containing monooxygenase 5, transcript variant 3 (from RefSeq NM_010232.5) ENSMUST00000107050.1 ENSMUST00000107050.2 ENSMUST00000107050.3 ENSMUST00000107050.4 ENSMUST00000107050.5 ENSMUST00000107050.6 ENSMUST00000107050.7 FMO5_MOUSE Fmo5 NM_010232 P97872 Q8R1W6 uc008qoy.1 uc008qoy.2 uc008qoy.3 uc008qoy.4 Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon- carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (By similarity). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (PubMed:26049045, PubMed:28646079). Reaction=H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N- dimethylaniline N-oxide + NADP(+); Xref=Rhea:RHEA:24468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16269, ChEBI:CHEBI:17735, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24469; Evidence=; Reaction=H(+) + NADPH + O2 = H2O2 + NADP(+); Xref=Rhea:RHEA:11260, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.6.3.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11261; Evidence=; Reaction=H(+) + heptan-2-one + NADPH + O2 = H2O + NADP(+) + pentyl acetate; Xref=Rhea:RHEA:54836, ChEBI:CHEBI:5672, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:87362; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54837; Evidence=; Reaction=H(+) + NADPH + O2 + octan-3-one = H2O + NADP(+) + pentyl propanoate; Xref=Rhea:RHEA:54840, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:80946, ChEBI:CHEBI:87373; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54841; Evidence=; Reaction=H(+) + NADPH + O2 + octan-3-one = ethyl hexanoate + H2O + NADP(+); Xref=Rhea:RHEA:54856, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:80946, ChEBI:CHEBI:86055; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54857; Evidence=; Reaction=H(+) + hexan-3-one + NADPH + O2 = ethyl butanoate + H2O + NADP(+); Xref=Rhea:RHEA:54844, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88764, ChEBI:CHEBI:89891; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54845; Evidence=; Reaction=H(+) + hexan-3-one + NADPH + O2 = H2O + NADP(+) + propyl propanoate; Xref=Rhea:RHEA:54848, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:89828, ChEBI:CHEBI:89891; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54849; Evidence=; Reaction=H(+) + heptan-4-one + NADPH + O2 = H2O + NADP(+) + propyl butanoate; Xref=Rhea:RHEA:54852, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:89484, ChEBI:CHEBI:89719; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54853; Evidence=; Reaction=(2E)-geranial + H(+) + NADPH + O2 = (1E)-2,6-dimethylhepta- 1,5-dien-1-yl formate + H2O + NADP(+); Xref=Rhea:RHEA:54860, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:138375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54861; Evidence=; Reaction=H(+) + NADPH + O2 + sulcatone = 4-methylpent-3-en-1-yl acetate + H2O + NADP(+); Xref=Rhea:RHEA:54864, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16310, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:138373; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54865; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Microsome membrane Endoplasmic reticulum membrane Expressed in liver (at protein level) (PubMed:26049045). Expressed in the mucosal epithelium of the gastrointestinal tract (PubMed:28646079). In the gastrointestinal tract, expression is induced in response to a high-fat diet. Mutants exhibit a lean phenotype, which is age- related, becoming apparent after 20 weeks of age. Despite greater food intake, they weigh less, store less fat in white adipose tissue (WAT), have lower plasma glucose and cholesterol concentrations and enhanced whole-body energy expenditure, due mostly to increased resting energy expenditure, with no increase in physical activity. They show a a higher rate of fatty acid oxidation in WAT (PubMed:26049045, PubMed:29686991). When fed a high-fat diet, they are protected against weight gain and reduction of insulin sensitivity (PubMed:28646079). Belongs to the FMO family. monooxygenase activity N,N-dimethylaniline monooxygenase activity endoplasmic reticulum endoplasmic reticulum membrane cytosol membrane integral component of membrane oxidoreductase activity organelle membrane intracellular membrane-bounded organelle flavin adenine dinucleotide binding NADP binding oxidation-reduction process uc008qoy.1 uc008qoy.2 uc008qoy.3 uc008qoy.4 
ENSMUST00000107060.8 Eftud2 ENSMUST00000107060.8 elongation factor Tu GTP binding domain containing 2, transcript variant 1 (from RefSeq NM_011431.3) ENSMUST00000107060.1 ENSMUST00000107060.2 ENSMUST00000107060.3 ENSMUST00000107060.4 ENSMUST00000107060.5 ENSMUST00000107060.6 ENSMUST00000107060.7 Eftud2 NM_011431 Q543F1 Q543F1_MOUSE uc033gal.1 uc033gal.2 uc033gal.3 Nucleus GTPase activity GTP binding uc033gal.1 uc033gal.2 uc033gal.3 
ENSMUST00000107067.8 E130114P18Rik ENSMUST00000107067.8 E130114P18Rik (from geneSymbol) A2AK50 A2AK50_MOUSE AK053617 E130114P18Rik ENSMUST00000107067.1 ENSMUST00000107067.2 ENSMUST00000107067.3 ENSMUST00000107067.4 ENSMUST00000107067.5 ENSMUST00000107067.6 ENSMUST00000107067.7 uc290nxe.1 uc290nxe.2 molecular_function cellular_component biological_process uc290nxe.1 uc290nxe.2 
ENSMUST00000107071.2 Gm12695 ENSMUST00000107071.2 predicted gene 12695 (from RefSeq NM_001081284.2) A2AGB2 CA087_MOUSE ENSMUST00000107071.1 NM_001081284 uc008ttm.1 uc008ttm.2 uc008ttm.3 molecular_function cellular_component biological_process uc008ttm.1 uc008ttm.2 uc008ttm.3 
ENSMUST00000107073.8 Higd1b ENSMUST00000107073.8 HIG1 domain family, member 1B, transcript variant 2 (from RefSeq NM_001357580.2) ENSMUST00000107073.1 ENSMUST00000107073.2 ENSMUST00000107073.3 ENSMUST00000107073.4 ENSMUST00000107073.5 ENSMUST00000107073.6 ENSMUST00000107073.7 HIG1B_MOUSE NM_001357580 Q8C1M5 Q99JY6 uc288crr.1 uc288crr.2 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc288crr.1 uc288crr.2 
ENSMUST00000107074.8 Cd160 ENSMUST00000107074.8 CD160 antigen, transcript variant 1 (from RefSeq NM_001163496.1) BY55_MOUSE By55 Cd160 ENSMUST00000107074.1 ENSMUST00000107074.2 ENSMUST00000107074.3 ENSMUST00000107074.4 ENSMUST00000107074.5 ENSMUST00000107074.6 ENSMUST00000107074.7 NM_001163496 O88875 Q8C9H4 uc008qog.1 uc008qog.2 uc008qog.3 [CD160 antigen]: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (By similarity). Receptor for both classical and non- classical MHC class I molecules (PubMed:16177084). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (PubMed:25711213). On activated CD4+ T cells, interacts with TNFRSF14 and down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (By similarity). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and pro- inflammatory cytokines (PubMed:22801499). [CD160 antigen, soluble form]: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions. Homomultimer; disulfide-linked (By similarity). Interacts with classical and non-classical MHC class I molecules (PubMed:16177084). Interacts with TNFRSF14 (via cysteine-rich domain 1); this interaction is direct (PubMed:18193050). Interacts with LCK and CD247/CD3 zeta chain (By similarity). [CD160 antigen]: Cell membrane ; Lipid- anchor, GPI-anchor [CD160 antigen, soluble form]: Secreted Note=Released from the cell membrane by GPI cleavage. Expressed in resting and activated NK cell subsets (at protein level) (PubMed:25711213, PubMed:16177084). Expressed in resting NKT cells (at protein level) (PubMed:16177084). Expressed in activated CD8+ T cells (at protein level). Highly expressed in intraepithelial lymphocyte (IEL) subsets, particularly in innate-like CD8A-positive IELs (at protein level) (PubMed:22801499). No visible phenotype. adaptive immune response immune system process mucosal immune response positive regulation of natural killer cell cytokine production regulation of adaptive immune response positive regulation of natural killer cell mediated immune response to tumor cell transmembrane signaling receptor activity receptor binding protein binding extracellular region plasma membrane phosphatidylinositol 3-kinase signaling membrane negative regulation of angiogenesis kinase binding MHC class I protein complex binding anchored component of membrane T cell costimulation MHC class I receptor activity MHC class Ib receptor activity activating MHC class I receptor activity positive regulation of natural killer cell degranulation innate immune response positive regulation of natural killer cell mediated cytotoxicity anchored component of plasma membrane defense response to Gram-negative bacterium negative regulation of T cell receptor signaling pathway negative regulation of CD4-positive, alpha-beta T cell costimulation positive regulation of interferon-gamma secretion negative regulation of adaptive immune memory response positive regulation of endothelial cell apoptotic process uc008qog.1 uc008qog.2 uc008qog.3 
ENSMUST00000107094.2 Jun ENSMUST00000107094.2 jun proto-oncogene (from RefSeq NM_010591.2) ENSMUST00000107094.1 Jun NM_010591 Q52L79 Q52L79_MOUSE uc008tsq.1 uc008tsq.2 uc008tsq.3 uc008tsq.4 Nucleus Belongs to the bZIP family. Jun subfamily. nuclear chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis release of cytochrome c from mitochondria DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity GTPase activator activity nucleus nucleoplasm nuclear euchromatin cytosol transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway Ras protein signal transduction aging learning circadian rhythm transcription factor binding positive regulation of cell proliferation response to radiation response to mechanical stimulus response to organic substance response to organic cyclic compound enzyme binding ubiquitin protein ligase binding response to lipopolysaccharide activating transcription factor binding response to cytokine cellular response to reactive oxygen species cAMP response element binding transcription factor AP-1 complex response to drug response to hydrogen peroxide identical protein binding protein homodimerization activity positive regulation of apoptotic process negative regulation of DNA binding positive regulation of neuron apoptotic process positive regulation of GTPase activity sequence-specific DNA binding negative regulation by host of viral transcription positive regulation by host of viral transcription transcription regulatory region DNA binding ubiquitin-like protein ligase binding positive regulation of monocyte differentiation positive regulation of DNA replication negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity positive regulation of smooth muscle cell proliferation cellular response to potassium ion starvation response to cAMP membrane depolarization SMAD protein signal transduction R-SMAD binding cellular response to cadmium ion HMG box domain binding positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of vascular smooth muscle cell proliferation negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of DNA-templated transcription, initiation uc008tsq.1 uc008tsq.2 uc008tsq.3 uc008tsq.4 
ENSMUST00000107095.5 Gm15441 ENSMUST00000107095.5 predicted gene 15441 (from RefSeq NR_040409.1) ENSMUST00000107095.1 ENSMUST00000107095.2 ENSMUST00000107095.3 ENSMUST00000107095.4 NR_040409 uc008qnb.1 uc008qnb.2 uc008qnb.3 uc008qnb.4 uc008qnb.5 uc008qnb.1 uc008qnb.2 uc008qnb.3 uc008qnb.4 uc008qnb.5 
ENSMUST00000107107.9 Plaa ENSMUST00000107107.9 phospholipase A2, activating protein, transcript variant 1 (from RefSeq NM_172695.3) A4QPD6 ENSMUST00000107107.1 ENSMUST00000107107.2 ENSMUST00000107107.3 ENSMUST00000107107.4 ENSMUST00000107107.5 ENSMUST00000107107.6 ENSMUST00000107107.7 ENSMUST00000107107.8 NM_172695 P27612 PLAP_MOUSE Plap Q8C6C4 uc008tsd.1 uc008tsd.2 uc008tsd.3 Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (By similarity). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (PubMed:28413018). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (By similarity). Plays a role in cerebellar Purkinje cell development (PubMed:28413018). Positively regulates cytosolic and calcium- independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:28007986). Interacts with ubiquitin. Interacts with UBXN6, VCP and YOD1; may form a complex involved in macroautophagy. Nucleus Cytoplasm Synapse Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. Expressed in the brain, with highest levels in hippocampal neurons, cerebellar granular cell layer and Purkinje cells (PubMed:28413018). At stage 11.5 dpc ubiquitously expressed (PubMed:28413018). In smooth muscle and endothelial cells by leukotriene D4, by tumor necrosis factor in endothelial cells and by uric acid crystals in macrophages. The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus. The PFU domain mediates interaction with ubiquitin. Mice die perinatally and exhibit spleen, lung and brain developmental anomalies (PubMed:28413018, PubMed:28007986). Display less matured and differentiated embryonic cortical neurons (PubMed:28007986). Display reduced ubiquitin-dependent membrane protein trafficking from early to late endosomes (PubMed:28413018). Show reduced prostaglandin E2 biosynthesis in embryonic brain, lung and heart, but not in liver at 18 dpc (PubMed:28007986). Belongs to the WD repeat PLAP family. Sequence=AAA39943.1; Type=Miscellaneous discrepancy; Note=Several frameshifts and contaminating sequence.; Evidence=; Sequence=Ref.3; Type=Frameshift; Evidence=; protein binding nucleus cytoplasm prostaglandin metabolic process inflammatory response multicellular organism development nervous system development ubiquitin homeostasis phospholipase A2 activator activity macroautophagy cell junction positive regulation of phospholipase A2 activity ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway synapse extracellular exosome cellular response to lipopolysaccharide negative regulation of protein K63-linked ubiquitination positive regulation of synaptic vesicle recycling positive regulation of dendrite extension positive regulation of neuron migration uc008tsd.1 uc008tsd.2 uc008tsd.3 
ENSMUST00000107108.8 Izumo3 ENSMUST00000107108.8 IZUMO family member 3 (from RefSeq NM_027034.1) A6PWV3 ENSMUST00000107108.1 ENSMUST00000107108.2 ENSMUST00000107108.3 ENSMUST00000107108.4 ENSMUST00000107108.5 ENSMUST00000107108.6 ENSMUST00000107108.7 IZUM3_MOUSE NM_027034 Q9DAG1 uc012dha.1 uc012dha.2 uc012dha.3 Monomer and homodimer. Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A6PWV3-1; Sequence=Displayed; Name=2; IsoId=A6PWV3-2; Sequence=VSP_034458; Sperm-specific (at protein level). Izumo is the name of a Japanese shrine to marriage. Belongs to the Izumo family. Sequence=BC099579; Type=Frameshift; Evidence=; cellular_component plasma membrane biological_process membrane integral component of membrane protein homodimerization activity uc012dha.1 uc012dha.2 uc012dha.3 
ENSMUST00000107120.8 Elavl2 ENSMUST00000107120.8 ELAV like RNA binding protein 1, transcript variant 9 (from RefSeq NM_001374237.1) B1AXZ4 B1AXZ4_MOUSE ENSMUST00000107120.1 ENSMUST00000107120.2 ENSMUST00000107120.3 ENSMUST00000107120.4 ENSMUST00000107120.5 ENSMUST00000107120.6 ENSMUST00000107120.7 Elavl2 NM_001374237 uc057lja.1 uc057lja.2 uc057lja.3 Belongs to the RRM elav family. nucleic acid binding RNA binding ribonucleoprotein complex uc057lja.1 uc057lja.2 uc057lja.3 
ENSMUST00000107127.8 Myo7a ENSMUST00000107127.8 myosin VIIA, transcript variant 2 (from RefSeq NM_008663.2) E9QLP7 ENSMUST00000107127.1 ENSMUST00000107127.2 ENSMUST00000107127.3 ENSMUST00000107127.4 ENSMUST00000107127.5 ENSMUST00000107127.6 ENSMUST00000107127.7 MYO7A_MOUSE Myo7 NM_008663 P97479 Q5MJ57 uc009ijy.1 uc009ijy.2 uc009ijy.3 uc009ijy.4 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Might homodimerize in a two headed molecule through the formation of a coiled-coil rod (By similarity). Identified in a complex with USH1C and USH1G (By similarity). Interacts with MYRIP (PubMed:12221080). Interacts with RPE65 (PubMed:21493626). Interacts with CIB2 (By similarity). May interact with CALM (By similarity). Interacts with WHRN (PubMed:15590698). Interacts with PLEKHB1 (via PH domain) (PubMed:15976448). Interacts with PCDH15 (PubMed:16481439). Interacts with TWF2 (PubMed:19774077). Interacts with USH1G (PubMed:21311020). Interacts with MYH9 (PubMed:27331610). Interacts (via MyTH4-FERM domains) with cytoplasmic regions of ADGRV1 and USH2A (PubMed:17567809). Interacts with PDZD7 (via MyTH4-FERM domains) (PubMed:27525485). P97479; O70309: Itgb5; NbExp=3; IntAct=EBI-1149557, EBI-8401821; P97479; Q91ZQ5: Rpe65; NbExp=3; IntAct=EBI-1149557, EBI-11682496; P97479; Q80T11: Ush1g; NbExp=4; IntAct=EBI-1149557, EBI-7418889; P97479; P18084: ITGB5; Xeno; NbExp=8; IntAct=EBI-1149557, EBI-1223434; Cytoplasm Cytoplasm, cell cortex Cytoplasm, cytoskeleton Synapse Note=In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region (By similarity). In retinal pigment epithelial cells colocalizes with a subset of melanosomes, displays predominant localization to stress fiber-like structures and some localization to cytoplasmic puncta (By similarity). Detected at the tip of cochlear hair cell stereocilia (PubMed:27525485). The complex formed by MYO7A, USH1C and USH1G colocalizes with F-actin (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P97479-1; Sequence=Displayed; Name=2; IsoId=P97479-2; Sequence=VSP_042238; Detected in mechanosensory stereocilia of cochlea hair cells (at protein level). Expressed in the retina, cochlea, kidney and liver. In the inner ear of the 16.5 day old embryo, expressed only in the cochlear and vestibular sensory hair cells. In addition, expression also occurs in the epithelial cells of the small intestine, hepatocytes, and choroidal plexus. The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha- helical structure by ionic bonds. Note=Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents an unconventional myosin. This protein should not be confused with the conventional myosin-7 (MYH7). Originally predicted to contain a coiled coil domain but proposed to contain a stable SAH domain instead. microfilament motor activity nucleotide binding photoreceptor outer segment phagolysosome assembly photoreceptor inner segment motor activity actin binding protein binding calmodulin binding ATP binding cytoplasm lysosomal membrane cytosol cytoskeleton microvillus cell cortex intracellular protein transport phagocytosis lysosome organization sensory perception visual perception sensory perception of sound apical plasma membrane myosin complex protein domain specific binding cell projection organization actin filament-based movement spectrin binding actin-dependent ATPase activity myosin VII complex photoreceptor connecting cilium stereocilium cellular protein localization melanosome inner ear morphogenesis mechanoreceptor differentiation auditory receptor cell differentiation protein homodimerization activity ADP binding macromolecular complex binding synapse protein N-terminus binding post-embryonic animal organ morphogenesis inner ear development sensory perception of light stimulus equilibrioception actin filament binding pigment granule localization pigment granule transport auditory receptor cell stereocilium organization inner ear receptor cell differentiation inner ear receptor stereocilium organization upper tip-link density uc009ijy.1 uc009ijy.2 uc009ijy.3 uc009ijy.4 
ENSMUST00000107129.2 Zfp352 ENSMUST00000107129.2 zinc finger protein 352 (from RefSeq NM_153102.3) A2AML7 A2AML7_MOUSE ENSMUST00000107129.1 NM_153102 Zfp352 uc008tom.1 uc008tom.2 uc008tom.3 Nucleus RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleic acid binding nucleus regulation of transcription from RNA polymerase II promoter uc008tom.1 uc008tom.2 uc008tom.3 
ENSMUST00000107152.9 Hdac5 ENSMUST00000107152.9 histone deacetylase 5, transcript variant 2 (from RefSeq NM_010412.4) ENSMUST00000107152.1 ENSMUST00000107152.2 ENSMUST00000107152.3 ENSMUST00000107152.4 ENSMUST00000107152.5 ENSMUST00000107152.6 ENSMUST00000107152.7 ENSMUST00000107152.8 Hdac5 NM_010412 Q3UJF1 Q3UJF1_MOUSE uc007lqv.1 uc007lqv.2 uc007lqv.3 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA- COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; Evidence=; Nucleus Belongs to the histone deacetylase family. HD type 2 subfamily. histone deacetylase complex histone deacetylase activity nucleus cytoplasm chromatin organization histone deacetylation hydrolase activity NAD-dependent histone deacetylase activity (H3-K14 specific) regulation of gene expression, epigenetic metal ion binding histone H3 deacetylation uc007lqv.1 uc007lqv.2 uc007lqv.3 
ENSMUST00000107153.3 Rsf1 ENSMUST00000107153.3 remodeling and spacing factor 1 (from RefSeq NM_001081267.2) E9PWW9 E9PWW9_MOUSE ENSMUST00000107153.1 ENSMUST00000107153.2 NM_001081267 Rsf1 uc009ijm.1 uc009ijm.2 uc009ijm.3 uc009ijm.4 histone acetyltransferase complex nuclear chromatin histone acetyltransferase activity nucleus nucleoplasm nucleosome assembly chromatin remodeling DNA-templated transcription, initiation regulation of transcription, DNA-templated histone acetylation nucleosome positioning RSF complex histone binding negative regulation of DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of viral transcription uc009ijm.1 uc009ijm.2 uc009ijm.3 uc009ijm.4 
ENSMUST00000107157.9 Slc24a2 ENSMUST00000107157.9 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2, transcript variant 1 (from RefSeq NM_172426.2) B1AXF2 B1AXF3 ENSMUST00000107157.1 ENSMUST00000107157.2 ENSMUST00000107157.3 ENSMUST00000107157.4 ENSMUST00000107157.5 ENSMUST00000107157.6 ENSMUST00000107157.7 ENSMUST00000107157.8 NCKX2_MOUSE NM_172426 Q14AY1 Q14BI1 Q8BUN9 Slc24a2 uc008tmk.1 uc008tmk.2 uc008tmk.3 uc008tmk.4 Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity). Required for learming and memory by regulating neuronal Ca(2+), which is essential for the development of synaptic plasticity (PubMed:16407245). Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29108; Evidence=; Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8BUN9-1; Sequence=Displayed; Name=2; IsoId=Q8BUN9-2; Sequence=VSP_061480, VSP_061481; Name=3; IsoId=Q8BUN9-3; Sequence=VSP_061481; Name=4; IsoId=Q8BUN9-4; Sequence=VSP_061481, VSP_061482; Name=5; IsoId=Q8BUN9-5; Sequence=VSP_061482; Mice display a significant reduction in Ca(2+) flux in cortical neurons, leading to a profound loss of long term potentiation and an increase in long term depression at hippocampal Schaffer/CA1 synapses, and clear deficits in specific tests of motor learning and spatial working memory (PubMed:16407245). Mice do not show any obvious loss of photoreceptor function in cones (PubMed:16407245). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. calcium channel activity integral component of plasma membrane ion transport calcium ion transport cellular calcium ion homeostasis visual perception learning memory calcium, potassium:sodium antiporter activity membrane integral component of membrane intrinsic component of plasma membrane ion transmembrane transport sodium ion transmembrane transport protein dimerization activity transmembrane transport long-term synaptic potentiation long term synaptic depression calcium ion transmembrane transport potassium ion transmembrane transport anion transmembrane transport uc008tmk.1 uc008tmk.2 uc008tmk.3 uc008tmk.4 
ENSMUST00000107162.8 Tenm4 ENSMUST00000107162.8 teneurin transmembrane protein 4, transcript variant 3 (from RefSeq NM_001310762.1) Doc4 ENSMUST00000107162.1 ENSMUST00000107162.2 ENSMUST00000107162.3 ENSMUST00000107162.4 ENSMUST00000107162.5 ENSMUST00000107162.6 ENSMUST00000107162.7 Kiaa1302 NM_001310762 O70465 Odz4 Q3TSI0 Q3UH52 Q3UHK6 Q80TF5 Q9WTS7 TEN4_MOUSE Tnm4 uc009iiq.1 uc009iiq.2 uc009iiq.3 uc009iiq.4 uc009iiq.5 Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer. Homodimer; disulfide-linked. May also form heterodimer with either TENM1 or TENM2 or TENM3. Cell membrane ; Single-pass membrane protein Cell projection Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=4; Comment=Additional mRNAs also exist. Tissue-specific expression of isoforms was observed throughout embryogenesis and in the brain and ovary adult tissues.; Name=1; IsoId=Q3UHK6-1; Sequence=Displayed; Name=2; IsoId=Q3UHK6-2; Sequence=VSP_021405, VSP_021407, VSP_021408; Name=3; IsoId=Q3UHK6-3; Sequence=VSP_021404, VSP_021405, VSP_021406; Name=4; IsoId=Q3UHK6-4; Sequence=VSP_021404; Expressed in brain and spinal cord (at protein level). Expressed in neurons and oligodendrocytes of the spinal cord. Expressed weakly in kidney, lung and spleen. Expressed in the cortex, CA1, CA2 and CA3 of the hippocampus. Expressed in the white matter, Purkinje cells and molecular layer of the cerebellum. Expressed in spinal cord at 18 dpc (at protein level). Expressed in the epiblast and extraembryonic regions as early as 6.5 dpc. Expressed in the neural plate and extraembryonic tissues at 7.5 dpc. Expressed in the forebrain, mid/hindbrain junction, somites and tail bud at 8.5 dpc. Expressed in the tail bud and limbs at 11.5 dpc. Expressed in the diencephalon and midbrain at 12.5 dpc. Up-regulated during oligodendrocyte differentiation. EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds. Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins. Mice show tremors and hypomyelination in the central nervous system (CNS), particularly in the spinal cord, but not in the sciatic nerve of the peripheral nervous system (PNS). Differentiation of oligodendrocytes is prevented in the spinal cord. Belongs to the tenascin family. Teneurin subfamily. gastrulation with mouth forming second nucleus cytoplasm plasma membrane integral component of plasma membrane heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules signal transduction multicellular organism development membrane integral component of membrane cell differentiation regulation of myelination positive regulation of myelination central nervous system myelin formation protein homodimerization activity cell projection neuron projection protein heterodimerization activity neuron development positive regulation of oligodendrocyte differentiation cell adhesion molecule binding cardiac muscle cell proliferation cardiac cell fate specification positive regulation of gastrulation uc009iiq.1 uc009iiq.2 uc009iiq.3 uc009iiq.4 uc009iiq.5 
ENSMUST00000107168.8 Mpp3 ENSMUST00000107168.8 Belongs to the MAGUK family. (from UniProt Q6XE40) BC052003 ENSMUST00000107168.1 ENSMUST00000107168.2 ENSMUST00000107168.3 ENSMUST00000107168.4 ENSMUST00000107168.5 ENSMUST00000107168.6 ENSMUST00000107168.7 Mpp3 Q6XE40 Q6XE40_MOUSE uc288cmj.1 uc288cmj.2 Belongs to the MAGUK family. kinase activity phosphorylation PDZ domain binding uc288cmj.1 uc288cmj.2 
ENSMUST00000107170.3 Setdb1 ENSMUST00000107170.3 SET domain, bifurcated 1, transcript variant 2 (from RefSeq NM_018877.3) D3YYC3 D3YYC3_MOUSE ENSMUST00000107170.1 ENSMUST00000107170.2 NM_018877 Setdb1 uc008qjm.1 uc008qjm.2 uc008qjm.3 Chromosome Nucleus DNA binding chromatin binding nucleus nucleoplasm chromosome cytoplasm cytosol plasma membrane Ras protein signal transduction methyltransferase activity zinc ion binding transferase activity histone-lysine N-methyltransferase activity methylation response to vitamin histone lysine methylation intracellular membrane-bounded organelle response to ethanol histone methyltransferase activity (H3-K9 specific) histone H3-K9 methylation positive regulation of methylation-dependent chromatin silencing promoter-specific chromatin binding uc008qjm.1 uc008qjm.2 uc008qjm.3 
ENSMUST00000107172.8 Dusp3 ENSMUST00000107172.8 Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity). (from UniProt Q9D7X3) AK170772 DUS3_MOUSE ENSMUST00000107172.1 ENSMUST00000107172.2 ENSMUST00000107172.3 ENSMUST00000107172.4 ENSMUST00000107172.5 ENSMUST00000107172.6 ENSMUST00000107172.7 Q9D7X3 uc288cma.1 uc288cma.2 Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Interacts with VRK3, which seems to activate it's phosphatase activity. Nucleus Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. inactivation of MAPK activity in utero embryonic development immunological synapse phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus nucleoplasm cytosol protein dephosphorylation cytoskeletal protein binding protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity protein kinase binding negative regulation of cell migration receptor tyrosine kinase binding MAP kinase phosphatase activity peptidyl-tyrosine dephosphorylation negative regulation of epidermal growth factor receptor signaling pathway negative regulation of MAPK cascade positive regulation of mitotic cell cycle negative regulation of JNK cascade negative regulation of T cell receptor signaling pathway negative regulation of T cell activation negative regulation of chemotaxis regulation of focal adhesion assembly negative regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity protein tyrosine kinase binding uc288cma.1 uc288cma.2 
ENSMUST00000107187.9 Mindy1 ENSMUST00000107187.9 MINDY lysine 48 deubiquitinase 1, transcript variant 1 (from RefSeq NM_199475.1) ENSMUST00000107187.1 ENSMUST00000107187.2 ENSMUST00000107187.3 ENSMUST00000107187.4 ENSMUST00000107187.5 ENSMUST00000107187.6 ENSMUST00000107187.7 ENSMUST00000107187.8 Fam63a MINY1_MOUSE NM_199475 Ni Q3TEF4 Q52KE4 Q566I9 Q6PES4 Q76LS9 Q80V14 Q8CB41 Q8CHR2 uc008qje.1 uc008qje.2 uc008qje.3 uc008qje.4 Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q76LS9-1; Sequence=Displayed; Name=2; IsoId=Q76LS9-2; Sequence=VSP_034718; Name=3; IsoId=Q76LS9-3; Sequence=VSP_034716, VSP_034717; Belongs to the MINDY deubiquitinase family. FAM63 subfamily. Sequence=AAH39762.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential vector sequence.; Evidence=; thiol-dependent ubiquitin-specific protease activity nucleus nucleoplasm cytosol proteolysis peptidase activity cysteine-type peptidase activity nuclear body hydrolase activity cysteine-type carboxypeptidase activity K48-linked polyubiquitin binding thiol-dependent ubiquitinyl hydrolase activity protein K48-linked deubiquitination Lys48-specific deubiquitinase activity uc008qje.1 uc008qje.2 uc008qje.3 uc008qje.4 
ENSMUST00000107195.9 Bnipl ENSMUST00000107195.9 BCL2/adenovirus E1B 19kD interacting protein like, transcript variant 1 (from RefSeq NM_134253.2) Bnipl E9QME1 E9QME1_MOUSE ENSMUST00000107195.1 ENSMUST00000107195.2 ENSMUST00000107195.3 ENSMUST00000107195.4 ENSMUST00000107195.5 ENSMUST00000107195.6 ENSMUST00000107195.7 ENSMUST00000107195.8 NM_134253 uc008qix.1 uc008qix.2 uc008qix.3 uc008qix.4 nucleus cytosol apoptotic process negative regulation of cell proliferation regulation of growth rate identical protein binding uc008qix.1 uc008qix.2 uc008qix.3 uc008qix.4 
ENSMUST00000107198.9 Bnc2 ENSMUST00000107198.9 basonuclin zinc finger protein 2, transcript variant 4 (from RefSeq NM_001369083.2) Bnc2 ENSMUST00000107198.1 ENSMUST00000107198.2 ENSMUST00000107198.3 ENSMUST00000107198.4 ENSMUST00000107198.5 ENSMUST00000107198.6 ENSMUST00000107198.7 ENSMUST00000107198.8 H3BIU2 H3BIU2_MOUSE NM_001369083 uc290nns.1 uc290nns.2 nucleic acid binding uc290nns.1 uc290nns.2 
ENSMUST00000107210.3 Sytl2 ENSMUST00000107210.3 synaptotagmin-like 2, transcript variant 3 (from RefSeq NM_031394.3) B2RS48 B7ZNS4 ENSMUST00000107210.1 ENSMUST00000107210.2 NM_031394 Q8BT37 Q99J89 Q99J90 Q99N50 Q99N51 Q99N52 Q99N55 Q99N56 SYTL2_MOUSE Slp2 uc291sof.1 uc291sof.2 Isoform 11 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. Required for cytotoxic granule docking at the immunologic synapse. Isoform 1 may play a role in melanosome transport and vesicle trafficking. It controls melanosome distribution in the cell periphery and regulates melanocyte morphology. Isoform 1 acts as a positive mediator of mucus secretion by the surface mucus cells of the stomach. Mediates basal mucus secretion by gastric surface cells by promoting the proper granule biognesis and docking of mucus granules with the apical plasma membrane. Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding. Interacts with RAB27B. [Isoform 1]: Melanosome membrane ; Peripheral membrane protein Note=Bound to melanosomes. Isoform 1 is localized mainly on peripheral melanosomes but not on less mature melanosomes around the nucleus. [Isoform 11]: Cell membrane te=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery. Event=Alternative splicing; Named isoforms=11; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Slp2-a; IsoId=Q99N50-1; Sequence=Displayed; Name=2; Synonyms=Slp2-b; IsoId=Q99N50-2; Sequence=VSP_007889; Name=3; Synonyms=Slp2-a delta 2S-I; IsoId=Q99N50-3; Sequence=VSP_007892; Name=4; Synonyms=Slp2-a delta 2S-II; IsoId=Q99N50-4; Sequence=VSP_007893; Name=5; Synonyms=Slp2-a delta 2S-III; IsoId=Q99N50-5; Sequence=VSP_007894; Name=6; Synonyms=Slp2-c; IsoId=Q99N50-6; Sequence=VSP_007890; Name=7; Synonyms=Slp2-d delta 2S-IV; IsoId=Q99N50-7; Sequence=VSP_007891; Name=8; IsoId=Q99N50-8; Sequence=VSP_007890, VSP_007894; Name=9; Synonyms=Slp2-e; IsoId=Q99N50-9; Sequence=Not described; Name=10; Synonyms=Slp2-f; IsoId=Q99N50-10; Sequence=Not described; Name=11; IsoId=Q99N50-11; Sequence=VSP_007893, VSP_007894; Highly expressed in brain, lung, kidney, testis and in embryos after day 7. Detected at lower levels in skeletal muscle. Expressed in pancreatic alpha cells. Isoform 6 is highly expressed in brain, but not detectable in the other tissues tested. Isoform 1 is expressed abundantly in the stomach and is predominantly localized at the apical region of gastric-surface mucus cells. Isoform 11 is expressed in cytotoxic T-lymphocytes (CTL). The RabBD domain mediates interaction with RAB27A. The C2 1 domain mediates localization to the cell membrane. Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A. Mice show a reduced number of mucus granules, a deficiency of granule docking with the apical plasma membrane in the gastric-surface mucus cells and reduction of mucus secretion by gastric primary cells. [Isoform 9]: Due to intron retention. [Isoform 10]: Due to intron retention. phosphatidylserine binding protein binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm plasma membrane intracellular protein transport exocytosis vesicle docking involved in exocytosis negative regulation of phosphatase activity membrane Rab GTPase binding extrinsic component of plasma membrane phosphatase binding melanosome membrane neurexin family protein binding melanosome positive regulation of mucus secretion exocytic vesicle protein localization to plasma membrane uc291sof.1 uc291sof.2 
ENSMUST00000107212.8 Nbr1 ENSMUST00000107212.8 Cytoplasmic vesicle, autophagosome Lysosome (from UniProt A2A4N7) A2A4N7 A2A4N7_MOUSE ENSMUST00000107212.1 ENSMUST00000107212.2 ENSMUST00000107212.3 ENSMUST00000107212.4 ENSMUST00000107212.5 ENSMUST00000107212.6 ENSMUST00000107212.7 Nbr1 U73039 uc288ckf.1 uc288ckf.2 Cytoplasmic vesicle, autophagosome Lysosome pre-autophagosomal structure zinc ion binding macroautophagy ubiquitin binding metal ion binding uc288ckf.1 uc288ckf.2 
ENSMUST00000107221.9 Ccdc83 ENSMUST00000107221.9 coiled-coil domain containing 83, transcript variant 1 (from RefSeq NM_183293.1) Ccdc83 D3YUZ0 D3YUZ0_MOUSE ENSMUST00000107221.1 ENSMUST00000107221.2 ENSMUST00000107221.3 ENSMUST00000107221.4 ENSMUST00000107221.5 ENSMUST00000107221.6 ENSMUST00000107221.7 ENSMUST00000107221.8 NM_183293 uc009igx.1 uc009igx.2 uc009igx.3 uc009igx.1 uc009igx.2 uc009igx.3 
ENSMUST00000107230.9 Frem1 ENSMUST00000107230.9 Fras1 related extracellular matrix protein 1, transcript variant 2 (from RefSeq NM_001198811.2) ENSMUST00000107230.1 ENSMUST00000107230.2 ENSMUST00000107230.3 ENSMUST00000107230.4 ENSMUST00000107230.5 ENSMUST00000107230.6 ENSMUST00000107230.7 ENSMUST00000107230.8 FREM1_MOUSE NM_001198811 Q5H8C2 Q5M7B3 Q684R7 Q8C732 uc290nmf.1 uc290nmf.2 uc290nmf.3 Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development. Interacts with FREM2. Secreted, extracellular space, extracellular matrix, basement membrane Note=Localizes at the basement membrane zone of embryonic epidermis and hair follicles. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q684R7-1; Sequence=Displayed; Name=2; IsoId=Q684R7-2; Sequence=VSP_015032; Name=3; IsoId=Q684R7-3; Sequence=VSP_015033, VSP_015034; Expressed in epidermis and hair follicles. Expressed in many developing epidermal appendages, including the whisker and sensory vibrissae, cranial and trunk hair follicles, meibomian glands, teeth, footpads, eyelash primordia and invaginating mammary glands. Limb expression localizes to sheets of dermal cells on the apical and basal surfaces of the digits but, unlike FRAS1, is excluded from the apical ectodermal ridge. Usually expressed at higher level in dermal cells underlying the differentiating epithelial components, especially underlying the epidermis of the head, limbs, and eyelids. Expression in the eyelid dermis is apparent as early as 13 dpc. Postnatal expression in the skin is limited to the dermal papillae. In the kidney, it is expressed from 12.5 dpc in the mesenchyme surrounding the branching ureteric tree, with a strong expression in the more proximal regions of these tubules rather than at the proliferating and branching ends of the ureteric buds. In hair follicle, it is selectively expressed in the vibrissal hair primordia during development. Preferentially expressed in the whisker pad epithelia of 12.5 dpc embryos, in both the epithelial and mesenchymal cells of developing hair follicles. In the early stages of hair follicle development (i.e. stages 0-1), it is expressed in both hair placodes and dermal condensations. In stage 2, it is detected in dermal condensations and adjacent epithelia, but not in the upper region of the hair follicles. Expressed at the tip of developing hair follicles in the later stages (i.e. stages 3-5). Expressed in the embryos of all stages examined and in some adult tissues including eye, kidney, ovary, urinary bladder and testes; however, the overall expression levels in adult tissues are relatively low compared with those in embryonic tissues. The Calx-beta domain binds calcium with high affinity and undergo a major conformational shift upon binding. Note=Defects in Frem1 are the cause of head blebs (heb) which is a spontaneous mutation that is characterized by absent or malformed eyes, which are often open at birth. Cryptophthalmos is noted in all heb homozygous animals, as is occasional hindlimb polydactyly. Was termed QBRICK because it contains 12 repeats: 'Q' stands for queen and is taken from the queen being the 12th in a suit of playing card, and 'BRICK' stands for the repeating unit. Frem1 also corresponds to a N-ethyl-N-nitrosourea- induced allele called 'bat'. Homozygous bat mice display similar phenotype than heb mice. Belongs to the FRAS1 family. Sequence=AAH88732.1; Type=Frameshift; Evidence=; Sequence=BAC35069.1; Type=Erroneous initiation; Evidence=; extracellular region basement membrane cell communication cell adhesion cell-matrix adhesion multicellular organism development integral component of membrane carbohydrate binding metal ion binding craniofacial suture morphogenesis uc290nmf.1 uc290nmf.2 uc290nmf.3 
ENSMUST00000107234.3 Eed ENSMUST00000107234.3 Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED- EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain. (from UniProt Q921E6) EED_MOUSE ENSMUST00000107234.1 ENSMUST00000107234.2 P97462 Q921E6 U78103 uc009igk.1 uc009igk.2 uc009igk.3 uc009igk.4 Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED- EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain. Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2 (By similarity). The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12 (By similarity). Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit (By similarity). Interacts with HDAC, HDAC2, histone H1 and YY1 (By similarity). May interact with ITGA4, ITGAE and ITGB7 (By similarity). Interacts with CDYL (By similarity). Interacts with EZH2. Interacts with KMT2A/MLL1 in adult brain. Interacts with BMAL1. Q921E6; Q7TNS8: Epop; NbExp=2; IntAct=EBI-904301, EBI-16024836; Q921E6; Q61188: Ezh2; NbExp=9; IntAct=EBI-904301, EBI-904311; Q921E6; Q61188-1: Ezh2; NbExp=5; IntAct=EBI-904301, EBI-15665134; Q921E6; Q62315: Jarid2; NbExp=11; IntAct=EBI-904301, EBI-493592; Q921E6; Q02395: Mtf2; NbExp=3; IntAct=EBI-904301, EBI-2531578; Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in cells of the early embryo and in stem cells of the extraembryonic trophectoderm lineage. Recruitment to the inactive X-chromosome requires XIST. Event=Alternative initiation; Named isoforms=3; Comment=Additional isoforms may be produced by alternative initiation from other non-canonical start codons but their precise positions have not been unambiguously determined. Name=1; Synonyms=EED-3; IsoId=Q921E6-1; Sequence=Displayed; Name=2; Synonyms=EED-1; IsoId=Q921E6-2; Sequence=VSP_034694; Name=3; Synonyms=EED-4; IsoId=Q921E6-3; Sequence=VSP_034693; Expressed in brain, heart, kidney, liver, lung, muscle, ovary, spleen and testis. Expressed throughout the brain. Maternally expressed. Expressed from 5.5 dpc, and expression remains high throughout development. Expression decreases during differentiation of embryonic stem cells (ES cells). Expression increases in prostate during prostate tumor development. Induced in embryonic stem cells (ES cells) by STAT3 and POU5F1. The WD repeat domain mediates recognition of trimethylated histone peptides at the consensus sequence Ala-Arg-Lys-Ser. This is achieved through an aromatic cage encircling the methyllysine, and involving Phe-97, Tyr-148 and Tyr-365 (By similarity). Methylated. Binding to histone H1 'Lys-26' promotes mono-, di-, and trimethylation of internal lysines (By similarity). Mice homozygous for a null allele of this protein (Pro- 196) exhibit disrupted anterior posterior patterning of the primitive streak during gastrulation and reduced numbers of trophoblast giant cells. Mice homozygous for a hypomorphic allele of this protein (Asn- 193) exhibit posterior transformations along the axial skeleton and altered patterns of Hox gene expression. [Isoform 2]: Translation initiates from a non-canonical start codon (GUG). Belongs to the WD repeat ESC family. Was originally thought (PubMed:9234727) to interact with HNRNPK. This apparent interaction may be mediated by the translated product of the 5'-UTR sequence of the 2-hybrid clone. Sequence=AAB38319.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAC53302.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH12966.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding sex chromatin chromatin binding protein binding nucleus nucleoplasm chromosome cytosol chromatin organization chromatin silencing regulation of gene expression by genetic imprinting histone methylation spinal cord development ESC/E(Z) complex histone methyltransferase activity identical protein binding pronucleus histone methyltransferase activity (H3-K27 specific) positive regulation of histone H3-K27 methylation histone H3-K27 methylation cellular response to leukemia inhibitory factor regulation of adaxial/abaxial pattern formation nucleosome binding uc009igk.1 uc009igk.2 uc009igk.3 uc009igk.4 
ENSMUST00000107236.9 Pip5k1a ENSMUST00000107236.9 phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha, transcript variant 2 (from RefSeq NM_008847.3) ENSMUST00000107236.1 ENSMUST00000107236.2 ENSMUST00000107236.3 ENSMUST00000107236.4 ENSMUST00000107236.5 ENSMUST00000107236.6 ENSMUST00000107236.7 ENSMUST00000107236.8 F8WIX5 NM_008847 P70182 PI51A_MOUSE Pip5k1a Q3U917 Q8K0D3 Q99L80 uc008qhx.1 uc008qhx.2 uc008qhx.3 uc008qhx.4 uc008qhx.5 Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:8798574, PubMed:9535851). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (PubMed:18772378). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (By similarity). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (PubMed:19153220). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (PubMed:19153220). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (PubMed:18772378). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (By similarity). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (PubMed:27739494). Together with PIP5K1C has a role during embryogenesis (PubMed:20622009). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:10679324). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:14425, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.68; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14426; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero- 3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+); Xref=Rhea:RHEA:40363, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77136, ChEBI:CHEBI:77137, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40364; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4- phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:65356, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:83423, ChEBI:CHEBI:83436, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65357; Evidence=; Reaction=1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D- myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl- sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+); Xref=Rhea:RHEA:40367, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77139, ChEBI:CHEBI:77140, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40368; Evidence=; Reaction=1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D- myo-inositol + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3- phospho-1D-myo-inositol 5-phosphate + ADP + H(+); Xref=Rhea:RHEA:40379, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77163, ChEBI:CHEBI:77164, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40380; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3- phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z,12Z)- octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+); Xref=Rhea:RHEA:40383, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77158, ChEBI:CHEBI:77159, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40384; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phospho-(1D-myo-inositol) + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+); Xref=Rhea:RHEA:40375, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77160, ChEBI:CHEBI:133606, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40376; Evidence=; Reaction=1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo- inositol + ATP = 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho- 1D-myo-inositol 5-phosphate + ADP + H(+); Xref=Rhea:RHEA:40387, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77165, ChEBI:CHEBI:77167, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40388; Evidence=; Activated by phosphatidic acid. Kinetic parameters: KM=26 uM for phosphatidylinositol-4-phosphate/PtdIns(4)P ; KM=33 uM for ATP ; Interacts with RAC1 (PubMed:10679324). Interacts with TUT1 (By similarity). Forms a complex with CDH1/E-cadherin, CTNNB1/beta-catenin and CTNND1 at the plasma membrane upon calcium stimulation (By similarity). Found in a ternary complex with IRS1 and DGKZ in the absence of insulin stimulation (PubMed:27739494). Interacts with DGKZ (By similarity). Interacts with PIP4K2C; the interaction inhibits PIP5K1A kinase activity (By similarity). Cell membrane Cytoplasm Nucleus Nucleus speckle Cell projection, ruffle Cell projection, lamellipodium Note=Colocalizes with RAC1 at actin- rich membrane ruffles (By similarity). Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P70182-1; Sequence=Displayed; Name=2; IsoId=P70182-2; Sequence=VSP_053437, VSP_016009; Name=3; IsoId=P70182-3; Sequence=VSP_053437; Highest expression in brain. Also detected in skeletal muscle, testis, brain and lung. Expression is highest during early embryogenesis and slightly decreases over time. Survive to adulthood, but bred poorly and display reduced fertility. Failed to form any vessel occlusion after chemical- induced carotid injury. Platelets have defective aggregation. Bone marrow-derived macrophages are defective in actin polymerization during phagocytosis. PIP5K1A and PIP5K1C double mutant mice are embryonic lethal. There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5- kinase type I alpha. nucleotide binding ruffle protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol mRNA cleavage and polyadenylation specificity factor complex plasma membrane phosphatidylinositol biosynthetic process phospholipid biosynthetic process fibroblast migration membrane kinase activity phosphatidylinositol phosphate kinase activity 1-phosphatidylinositol-4-phosphate 5-kinase activity phosphorylation nuclear speck transferase activity kinase binding lamellipodium actin cytoskeleton reorganization ruffle membrane cell projection phosphatidylinositol metabolic process phosphatidylinositol phosphorylation focal adhesion assembly cell chemotaxis protein localization to plasma membrane activation of GTPase activity ruffle assembly uc008qhx.1 uc008qhx.2 uc008qhx.3 uc008qhx.4 uc008qhx.5 
ENSMUST00000107237.8 Psmd4 ENSMUST00000107237.8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4, transcript variant 2 (from RefSeq NM_008951.3) ENSMUST00000107237.1 ENSMUST00000107237.2 ENSMUST00000107237.3 ENSMUST00000107237.4 ENSMUST00000107237.5 ENSMUST00000107237.6 ENSMUST00000107237.7 Mcb1 NM_008951 O35226 PSMD4_MOUSE Q91V59 Q9JJM0 Q9JJM1 Q9JJM2 Q9JJM3 uc008qhr.1 uc008qhr.2 uc008qhr.3 uc008qhr.4 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin- interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD4 (PubMed:16857966). Interacts with NUB1. Interacts with SQSTM1. Interacts with UBQLN4. Interacts with UBE3A. Interacts with UBQLN1 (via ubiquitin-like domain). Interacts with DDI2 (By similarity). Event=Alternative splicing; Named isoforms=5; Name=Rpn10A; IsoId=O35226-1; Sequence=Displayed; Name=Rpn10B; IsoId=O35226-2; Sequence=VSP_005293; Name=Rpn10C; IsoId=O35226-3; Sequence=VSP_005293, VSP_005294, VSP_005295; Name=Rpn10D; IsoId=O35226-4; Sequence=VSP_005296, VSP_005297; Name=Rpn10E; IsoId=O35226-5; Sequence=VSP_005298, VSP_005299; Isoform Rpn10A is ubiquitous whereas isoform Rpn10E is mostly expressed in the embryonic brain. Isoform Rpn10E is expressed only in the embryos. The 2 UIM motifs are involved in the binding to a multi- ubiquitin chain in a cooperative way. Belongs to the proteasome subunit S5A family. proteasome complex nucleus nucleoplasm cytoplasm cytosol transcription factor binding proteasome regulatory particle, base subcomplex proteasome accessory complex polyubiquitin binding identical protein binding proteasome-mediated ubiquitin-dependent protein catabolic process proteasome assembly uc008qhr.1 uc008qhr.2 uc008qhr.3 uc008qhr.4 
ENSMUST00000107252.9 Ptges3l ENSMUST00000107252.9 prostaglandin E synthase 3 like, transcript variant 1 (from RefSeq NM_001357574.1) A2A4P5 A2A4P5_MOUSE ENSMUST00000107252.1 ENSMUST00000107252.2 ENSMUST00000107252.3 ENSMUST00000107252.4 ENSMUST00000107252.5 ENSMUST00000107252.6 ENSMUST00000107252.7 ENSMUST00000107252.8 NM_001357574 Ptges3l uc007lou.1 uc007lou.2 uc007lou.3 Belongs to the p23/wos2 family. uc007lou.1 uc007lou.2 uc007lou.3 
ENSMUST00000107256.4 Rab38 ENSMUST00000107256.4 RAB38, member RAS oncogene family (from RefSeq NM_028238.7) ENSMUST00000107256.1 ENSMUST00000107256.2 ENSMUST00000107256.3 NM_028238 Q8QZZ8 Q9D7E8 RAB38_MOUSE uc009ifv.1 uc009ifv.2 Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (PubMed:21187289). Plays an important role in the control of melanin production and melanosome biogenesis (By similarity). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560). Regulated by a guanine nucleotide-exchange factor (GEF) and a GTPase-activating protein (GAP) and alternates between an inactive GDP-bound and an active GTP-bound form. The BLOC-3 complex composed of HPS1 and HPS4 acts as its GEF, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. SGSM2 acts as its GAP and inactivates it by stimulating its GTPase activity (PubMed:26620560). Interacts with ANKRD27 (By similarity). Q8QZZ8; Q3UMR0: Ankrd27; NbExp=5; IntAct=EBI-1993463, EBI-1993429; Cell membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasmic vesicle, phagosome Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side Melanosome Melanosome membrane Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization. Note=Defects in Rab38 are the cause of a form of oculocutaneous albinism known as the chocolate (cht) phenotype. Mice exhibit a brown coat similar in color to mice with a mutation in tyrosinase-related protein 1 (TYRP1). The targeting of TYRP1 protein to the melanosome is impaired in Rab38(cht)/Rab38(cht) melanocytes. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity protein binding GTP binding cytoplasm mitochondrion lysosome early endosome endoplasmic reticulum Golgi apparatus trans-Golgi network cytosol plasma membrane intracellular protein transport organelle organization mitochondrion organization protein transport membrane vesicle-mediated transport phagocytic vesicle membrane GTP-dependent protein binding cytoplasmic vesicle vesicle Rab protein signal transduction melanosome membrane endosome to melanosome transport AP-1 adaptor complex binding AP-3 adaptor complex binding BLOC-2 complex binding melanosome ER-mitochondrion membrane contact site phagocytic vesicle platelet dense granule organization protein localization to membrane phagosome acidification melanosome assembly positive regulation of phosphatidylcholine biosynthetic process uc009ifv.1 uc009ifv.2 
ENSMUST00000107258.9 Mpdz ENSMUST00000107258.9 multiple PDZ domain crumbs cell polarity complex component, transcript variant 3 (from RefSeq NM_001305286.1) B7ZNA1 ENSMUST00000107258.1 ENSMUST00000107258.2 ENSMUST00000107258.3 ENSMUST00000107258.4 ENSMUST00000107258.5 ENSMUST00000107258.6 ENSMUST00000107258.7 ENSMUST00000107258.8 MPDZ_MOUSE Mupp1 NM_001305286 O08783 Q6P7U4 Q80ZY8 Q8BKJ1 Q8C0H8 Q8VBV5 Q8VBX6 Q8VBY0 Q9Z1K3 uc290nkq.1 uc290nkq.2 Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (By similarity). Promotes clustering of HT2RC at the cell surface (By similarity). Interacts with CLDN5, DLG4, GRIN1, SYNGAP1, CAMK2A and CAMK2B, HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1 and PLEKHA2/TAPP2 (By similarity). Interacts with F11R/JAM, CLDN1, NG2, CXADR, CRB1, MPP4 and PALS1. Interacts with FAT4 (via cytoplasmic domain). Interacts with DLL1 (PubMed:15509766). Q8VBX6; O88551: Cldn1; NbExp=2; IntAct=EBI-8026435, EBI-7158428; Q8VBX6; P10721: KIT; Xeno; NbExp=4; IntAct=EBI-8026435, EBI-1379503; Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Postsynaptic density. Cell projection, dendrite. Cell junction, tight junction Synapse. Synapse, synaptosome Note=Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD) (By similarity). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8VBX6-1; Sequence=Displayed; Name=2; IsoId=Q8VBX6-2; Sequence=VSP_014201; Name=3; IsoId=Q8VBX6-3; Sequence=VSP_058771; Name=4; IsoId=Q8VBX6-4; Sequence=VSP_014202; In the brain, it is strongly expressed in the choroid plexus. Within the hippocampal formation, strongest expression was seen in the soma of CA1-4 pyramidal cells. Expressed in most neocortical regions with the strongest expression in piriform cortex and amygdaloid nuclei but also detected in the subiculum and olfactory bulb. In the cerebellum, the highest level of expression was found in Purkinje cells. Moderately expressed in the granular layer and molecular layer. Expressed in the pontine nuclei, parts of spinal trigeminal nuclei, and the principal sensory trigeminal nuclei of the metencephalon. Expressed in all thalamic and hypothalamic nuclei, and the substantia nigra (at protein level). Ubiquitously expressed. Expressed at the outer limiting membrane of the retina at 3 months of age. The PDZ domain 2 mainly binds CAMK2A and CAMK2B. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 10 binds the C-terminal PDZ-binding motif of HTR2C. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1 (By similarity). The PDZ domain 1 binds NG2. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT. The PDZ domain 13 binds CXADR. Sequence=BAC27346.1; Type=Frameshift; Evidence=; Sequence=BAC34766.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; protein binding cytoplasm plasma membrane bicellular tight junction cell adhesion protein C-terminus binding postsynaptic density membrane apical plasma membrane apicolateral plasma membrane cell junction dendrite cytoplasmic vesicle myelination cell projection neuron projection Schmidt-Lanterman incisure synapse postsynaptic membrane uc290nkq.1 uc290nkq.2 
ENSMUST00000107259.4 Gm27029 ENSMUST00000107259.4 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; (from UniProt A2A4P4) A2A4P4 A2A4P4_MOUSE AK136332 ENSMUST00000107259.1 ENSMUST00000107259.2 ENSMUST00000107259.3 Gm27029 uc288cjf.1 uc288cjf.2 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Cytoplasm Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. nucleotide binding Ser-tRNA(Ala) hydrolase activity nucleic acid binding aminoacyl-tRNA ligase activity alanine-tRNA ligase activity ATP binding alanyl-tRNA aminoacylation regulation of translational fidelity tRNA aminoacylation uc288cjf.1 uc288cjf.2 
ENSMUST00000107270.9 Pogz ENSMUST00000107270.9 pogo transposable element with ZNF domain, transcript variant 1 (from RefSeq NM_172683.4) ENSMUST00000107270.1 ENSMUST00000107270.2 ENSMUST00000107270.3 ENSMUST00000107270.4 ENSMUST00000107270.5 ENSMUST00000107270.6 ENSMUST00000107270.7 ENSMUST00000107270.8 Kiaa0461 NM_172683 POGZ_MOUSE Q4VA94 Q80TZ8 Q8BZH4 Q8C0K1 Q8K294 uc008qhc.1 uc008qhc.2 uc008qhc.3 uc008qhc.4 uc008qhc.5 Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (By similarity). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (By similarity). Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5 (By similarity). Interacts (via IBM motif) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (By similarity). Interacts with HDGFL2 (By similarity). Nucleus Chromosome Cytoplasm Note=Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3). Phosphorylation increases its interaction with PSIP1. nuclear chromatin RNA polymerase II core promoter sequence-specific DNA binding nucleic acid binding DNA binding nucleus nucleoplasm chromosome cytoplasm cytosol cell cycle mitotic sister chromatid cohesion regulation of gene expression metal ion binding cell division kinetochore assembly histone methyltransferase complex uc008qhc.1 uc008qhc.2 uc008qhc.3 uc008qhc.4 uc008qhc.5 
ENSMUST00000107283.8 Snx27 ENSMUST00000107283.8 sorting nexin family member 27, transcript variant 1 (from RefSeq NM_001082484.2) ENSMUST00000107283.1 ENSMUST00000107283.2 ENSMUST00000107283.3 ENSMUST00000107283.4 ENSMUST00000107283.5 ENSMUST00000107283.6 ENSMUST00000107283.7 Kiaa0488 NM_001082484 Q3UHD6 Q7TQL6 Q80TZ1 Q9CYB5 SNX27_MOUSE uc008qgs.1 uc008qgs.2 uc008qgs.3 uc008qgs.4 Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C- terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. Core component of the SNX27-retromer, a multiprotein complex composed of SNX27, the WASH complex and the retromer complex. Interacts (via the FERM-like regions) with the WASH complex. Interacts with SNX1. Interacts with CYTIP. Interacts with DGKZ. Interacts with MCC (By similarity). Interacts (via PDZ domain) with a number of target transmembrane proteins (via PDZ-binding motif): ABCC4, ADRB2, ARHGEF7, GRIA1, GRIA2, GRIN1, GRIN2A GRIN2C, KCNJ6, KCNJ9 and SLC2A1/GLUT1. Interacts (via PDZ domains) with SLC9A3; directs SLC9A3 membrane insertion from early endosomes to the plasma membrane (By similarity). Early endosome membrane ; Peripheral membrane protein Cytoplasm, cytosol Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3- kinase products (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SNX27a; IsoId=Q3UHD6-1; Sequence=Displayed; Name=2; Synonyms=SNX27b; IsoId=Q3UHD6-2; Sequence=VSP_030540; Expressed in cells of hematopoietic origin. The PDZ domain mediates binding to a subset of proteins containing a PDZ-binding motif at the C-terminus: the specificity for PDZ-binding motif is provided by the 2 residues located upstream of the canonical PDZ-binding motif. The PDZ domain also mediates binding to the retromer complex via direct interaction with VPS26 (VPS26A or VPS26B). The PX domain mediates binding to phosphatidylinositol 3- phosphate (PtdIns(3P)) and localization to early endosome membranes. Growth retardation followed by lethality. Some mice die in the uterus during embryonic development. Newborn mice that survive fail to thrive and all die at different times within the first 3 weeks. The body weight of newborn is lower than wild-type mice, and the postnatal growth is severely retarded, with a clear retardation of body weight gain. The growth retardation is not only reflected in the body weight, but also in multiple organs, such as the spleen, kidney, liver, heart and intestine. Mice also show neuronal deficits in the hippocampus and cortex: despite a normal neuroanatomy, defects in synaptic function, learning and memory and a reduction in the amounts of ionotropic glutamate receptors (NMDA and AMPA receptors) are observed. Sequence=BAB30966.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB30966.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; immunological synapse protein binding nucleoplasm cytoplasm endosome early endosome cytosol plasma membrane intracellular protein transport signal transduction lipid binding endosome to lysosome transport postsynaptic density protein transport membrane endosomal transport retromer complex early endosome membrane phosphatidylinositol-3-phosphate binding phosphatidylinositol binding ionotropic glutamate receptor binding WASH complex endosome to plasma membrane protein transport negative regulation of inward rectifier potassium channel activity positive regulation of AMPA glutamate receptor clustering retrograde transport, endosome to plasma membrane uc008qgs.1 uc008qgs.2 uc008qgs.3 uc008qgs.4 
ENSMUST00000107285.8 Ezh1 ENSMUST00000107285.8 enhancer of zeste 1 polycomb repressive complex 2 subunit, transcript variant 1 (from RefSeq NM_007970.4) A0A0R4J1C0 A0A0R4J1C0_MOUSE ENSMUST00000107285.1 ENSMUST00000107285.2 ENSMUST00000107285.3 ENSMUST00000107285.4 ENSMUST00000107285.5 ENSMUST00000107285.6 ENSMUST00000107285.7 Ezh1 NM_007970 uc288chj.1 uc288chj.2 This gene encodes a member of the Polycomb-group (PcG) family. The encoded protein is interchangeable with the related Enhancer of zeste 2 (Ezh2) protein as a core component of the polycomb repressive complex 2 (PRC2), which methylates histone H3 at lysine 27 and results in the transcriptional repression of affected target genes. This complex is involved in carrying out cell-fate decisions during embryonic stem cell differentiation. [provided by RefSeq, Sep 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007135.1, AK140694.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA- COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356; Evidence=; Nucleus chromatin binding nucleus nucleoplasm histone-lysine N-methyltransferase activity hippocampus development ESC/E(Z) complex positive regulation of transcription from RNA polymerase II promoter histone H3-K27 methylation uc288chj.1 uc288chj.2 
ENSMUST00000107289.9 Ptprd ENSMUST00000107289.9 Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically (PubMed:25908590). Involved in pre-synaptic differentiation through interaction with SLITRK2 (PubMed:25989451). (from UniProt Q64487) ENSMUST00000107289.1 ENSMUST00000107289.2 ENSMUST00000107289.3 ENSMUST00000107289.4 ENSMUST00000107289.5 ENSMUST00000107289.6 ENSMUST00000107289.7 ENSMUST00000107289.8 G3X9S7 NM_001428308 PTPRD_MOUSE Q64486 Q64487 Q64488 Q64495 Q8VBV0 uc290nix.1 uc290nix.2 Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically (PubMed:25908590). Involved in pre-synaptic differentiation through interaction with SLITRK2 (PubMed:25989451). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Interacts with PPFIA1, PPFIA2 and PPFIA3 (By similarity). Interacts (via extracellular domain) with SLITRK4 (via LRR 1 and 2 repeats) (PubMed:25989451). Interacts with SLITRK2; induces presynaptic differentiation (PubMed:25989451). Interacts (via the second immunoglobilin domain) with IL1RAPL1 (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons and synapse formation. Isoform G, isoform H, isoform I, isoform J, and isoform K do not interact with IL1RAPL1 (PubMed:25908590, PubMed:21940441). Interacts (via the third immunoglobilin domain) with IL1RAP (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (PubMed:25908590). Q64487; P59823: Il1rapl1; NbExp=6; IntAct=EBI-771834, EBI-5452114; Membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=12; Comment=Additional isoforms seem to exist.; Name=D; Synonyms=delta; IsoId=Q64487-4; Sequence=Displayed; Name=C; IsoId=Q64487-1; Sequence=VSP_043549, VSP_043550, VSP_043552; Name=A; IsoId=Q64487-2; Sequence=VSP_043545, VSP_043546, VSP_043551, VSP_043553; Name=B; IsoId=Q64487-3; Sequence=VSP_043545, VSP_043546, VSP_043552; Name=E; Synonyms=delta-DelB; IsoId=Q64487-5; Sequence=VSP_043550; Name=F; Synonyms=deltaA6; IsoId=Q64487-6; Sequence=VSP_043548; Name=G; Synonyms=deltaA6-DelB; IsoId=Q64487-7; Sequence=VSP_043548, VSP_043550; Name=H; Synonyms=deltaA3; IsoId=Q64487-8; Sequence=VSP_043549; Name=I; Synonyms=deltaA3-DelB; IsoId=Q64487-9; Sequence=VSP_043549, VSP_043550; Name=J; Synonyms=delta-DelA; IsoId=Q64487-10; Sequence=VSP_043547; Name=K; Synonyms=delta-DelAB; IsoId=Q64487-11; Sequence=VSP_043547, VSP_043550; Name=L; Synonyms=delta A; IsoId=Q64487-12; Sequence=VSP_043551, VSP_043553; Brain, kidney, heart, and some B-cell lines. A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity). Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. Sequence=BAA03004.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; phosphoprotein phosphatase activity protein tyrosine phosphatase activity receptor binding protein binding protein dephosphorylation heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity neuron differentiation peptidyl-tyrosine dephosphorylation negative regulation of JAK-STAT cascade positive regulation of dendrite morphogenesis regulation of immune response modulation of synaptic transmission cell adhesion molecule binding positive regulation of synapse assembly presynaptic membrane assembly glutamatergic synapse integral component of presynaptic membrane synaptic membrane adhesion uc290nix.1 uc290nix.2 
ENSMUST00000107302.8 Mlx ENSMUST00000107302.8 MAX-like protein X, transcript variant 7 (from RefSeq NR_189305.1) A2BFB1 A2BFB1_MOUSE ENSMUST00000107302.1 ENSMUST00000107302.2 ENSMUST00000107302.3 ENSMUST00000107302.4 ENSMUST00000107302.5 ENSMUST00000107302.6 ENSMUST00000107302.7 Mlx NR_189305 uc007lnf.1 uc007lnf.2 uc007lnf.3 uc007lnf.4 regulation of transcription, DNA-templated transcription factor binding protein dimerization activity uc007lnf.1 uc007lnf.2 uc007lnf.3 uc007lnf.4 
ENSMUST00000107305.8 Hdgfl3 ENSMUST00000107305.8 HDGF like 3 (from RefSeq NM_013886.4) ENSMUST00000107305.1 ENSMUST00000107305.2 ENSMUST00000107305.3 ENSMUST00000107305.4 ENSMUST00000107305.5 ENSMUST00000107305.6 ENSMUST00000107305.7 HDGR3_MOUSE Hdgfrp3 NM_013886 Q3TRX2 Q8BQ69 Q8BR62 Q9D2M7 Q9JMG7 uc009icr.1 uc009icr.2 uc009icr.3 Enhances DNA synthesis and may play a role in cell proliferation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JMG7-1; Sequence=Displayed; Name=2; IsoId=Q9JMG7-2; Sequence=VSP_014188; Belongs to the HDGF family. Sequence=BAC32413.1; Type=Frameshift; Evidence=; chromatin binding protein binding nucleus nucleoplasm cytoplasm cytosol negative regulation of microtubule depolymerization signal transduction microtubule binding growth factor activity tubulin binding neuron projection development microtubule polymerization uc009icr.1 uc009icr.2 uc009icr.3 
ENSMUST00000107310.9 Msantd5f9 ENSMUST00000107310.9 Myb/SANT DNA binding domain containing 5 family member 9 (from RefSeq NM_001126326.2) A2BEJ1 A2BEJ1_MOUSE ENSMUST00000107310.1 ENSMUST00000107310.2 ENSMUST00000107310.3 ENSMUST00000107310.4 ENSMUST00000107310.5 ENSMUST00000107310.6 ENSMUST00000107310.7 ENSMUST00000107310.8 Gm11756 Msantd5f9 NM_001126326 uc290nhz.1 uc290nhz.2 molecular_function cellular_component biological_process uc290nhz.1 uc290nhz.2 
ENSMUST00000107319.8 Msantd5f10 ENSMUST00000107319.8 Myb/SANT DNA binding domain containing 5 family member 10 (from RefSeq NM_001177578.2) A2BEI6 A2BEI6_MOUSE ENSMUST00000107319.1 ENSMUST00000107319.2 ENSMUST00000107319.3 ENSMUST00000107319.4 ENSMUST00000107319.5 ENSMUST00000107319.6 ENSMUST00000107319.7 Gm11758 Gm13871 NM_001177578 OTTMUSG00000014862 uc008tjd.1 uc008tjd.2 uc008tjd.3 uc008tjd.4 uc008tjd.5 This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is supported by alignment of transcripts. [provided by RefSeq, Mar 2013]. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849390, SAMN01164137 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## molecular_function cellular_component biological_process uc008tjd.1 uc008tjd.2 uc008tjd.3 uc008tjd.4 uc008tjd.5 
ENSMUST00000107321.9 Msantd5f8 ENSMUST00000107321.9 Myb/SANT DNA binding domain containing 5 family member 8 (from RefSeq NM_001085538.2) A2BEI8 A2BEI8_MOUSE ENSMUST00000107321.1 ENSMUST00000107321.2 ENSMUST00000107321.3 ENSMUST00000107321.4 ENSMUST00000107321.5 ENSMUST00000107321.6 ENSMUST00000107321.7 ENSMUST00000107321.8 Gm11757 Msantd5f8 NM_001085538 uc008tjb.1 uc008tjb.2 uc008tjb.3 uc008tjb.4 uc008tjb.5 This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is inferred from alignment of paralogous transcripts. [provided by RefSeq, Mar 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on paralogous alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849390, SAMN01164137 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## molecular_function cellular_component biological_process uc008tjb.1 uc008tjb.2 uc008tjb.3 uc008tjb.4 uc008tjb.5 
ENSMUST00000107327.8 Msantd5f7 ENSMUST00000107327.8 Myb/SANT DNA binding domain containing 5 family member 7 (from RefSeq NM_001097978.2) A2BEI6 A2BEI6_MOUSE ENSMUST00000107327.1 ENSMUST00000107327.2 ENSMUST00000107327.3 ENSMUST00000107327.4 ENSMUST00000107327.5 ENSMUST00000107327.6 ENSMUST00000107327.7 Gm11758 Gm13871 NM_001097978 OTTMUSG00000014862 uc008tiz.1 uc008tiz.2 uc008tiz.3 This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is supported by transcript alignments. [provided by RefSeq, May 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## molecular_function cellular_component biological_process uc008tiz.1 uc008tiz.2 uc008tiz.3 
ENSMUST00000107329.8 S100a5 ENSMUST00000107329.8 S100 calcium binding protein A5, transcript variant 1 (from RefSeq NM_011312.3) ENSMUST00000107329.1 ENSMUST00000107329.2 ENSMUST00000107329.3 ENSMUST00000107329.4 ENSMUST00000107329.5 ENSMUST00000107329.6 ENSMUST00000107329.7 NM_011312 Q149U2 Q149U2_MOUSE S100a5 uc008qda.1 uc008qda.2 uc008qda.3 Belongs to the S-100 family. copper ion binding calcium ion binding nucleus zinc ion binding protein homodimerization activity metal ion binding transition metal ion binding uc008qda.1 uc008qda.2 uc008qda.3 
ENSMUST00000107330.3 Gm42674 ENSMUST00000107330.3 Gm42674 (from geneSymbol) D3YUT9 D3YUT9_MOUSE ENSMUST00000107330.1 ENSMUST00000107330.2 Gm42674 Z36947 uc290hdj.1 uc290hdj.2 calcium ion binding zinc ion binding uc290hdj.1 uc290hdj.2 
ENSMUST00000107348.2 Alpk3 ENSMUST00000107348.2 alpha-kinase 3 (from RefSeq NM_054085.2) ALPK3_MOUSE Alpk3 D3YUT2 ENSMUST00000107348.1 Kiaa1330 NM_054085 Q5DTY6 Q8C7A3 Q924C5 uc009ibr.1 uc009ibr.2 Involved in cardiomyocyte differentiation. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Nucleus Expressed in the heart and skeletal muscle of adult mice. First detected in the cardiac crescent at 7.5 dpc when the developing heart became visible and remains through to 10.5 dpc. Mice are viable and were born at the expected Mendelian ratio. They however develop spontaneous cardiomyopathy with features of both hypertrophic and dilated forms of cardiomyopathy. Cardiac hypertrophy is characterized by increased thickness of both left and right ventricular walls and by significantly increased heart weight. Some features are also associated with dilated cardiomyopathy. Cardiomyocytes show an altered architecture, characterized by reduced numbers of abnormal intercalated disks. Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. Sequence=AAK60496.1; Type=Frameshift; Evidence=; molecular_function protein serine/threonine kinase activity ATP binding nucleus protein phosphorylation multicellular organism development heart development kinase activity phosphorylation transferase activity cardiac muscle cell differentiation cardiac muscle cell development uc009ibr.1 uc009ibr.2 
ENSMUST00000107353.3 Zfp592 ENSMUST00000107353.3 zinc finger protein 592 (from RefSeq NM_178707.4) ENSMUST00000107353.1 ENSMUST00000107353.2 Kiaa0211 NM_178707 Q80XM1 Q8BHZ4 ZN592_MOUSE Znf592 uc009ibp.1 uc009ibp.2 uc009ibp.3 uc009ibp.4 May be involved in transcriptional regulation. Interacts with ZMYND8. Nucleus Expressed in the brain. Expressed in the embryo at least from 10 dpc until birth. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC31327.1; Type=Frameshift; Evidence=; Sequence=BAC97899.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding protein binding nucleus biological_process metal ion binding uc009ibp.1 uc009ibp.2 uc009ibp.3 uc009ibp.4 
ENSMUST00000107359.9 Megf9 ENSMUST00000107359.9 multiple EGF-like-domains 9 (from RefSeq NM_172694.2) ENSMUST00000107359.1 ENSMUST00000107359.2 ENSMUST00000107359.3 ENSMUST00000107359.4 ENSMUST00000107359.5 ENSMUST00000107359.6 ENSMUST00000107359.7 ENSMUST00000107359.8 Egfl5 Kiaa0818 MEGF9_MOUSE NM_172694 Q8BH27 Q8BWI4 uc008tib.1 uc008tib.2 uc008tib.3 Membrane ; Single-pass type I membrane protein It is uncertain whether Met-1 or Met-9 is the initiator. extracellular matrix structural constituent basement membrane animal organ morphogenesis tissue development membrane integral component of membrane cell migration substrate adhesion-dependent cell spreading laminin complex basement membrane assembly uc008tib.1 uc008tib.2 uc008tib.3 
ENSMUST00000107362.10 Furin ENSMUST00000107362.10 furin, paired basic amino acid cleaving enzyme, transcript variant 2 (from RefSeq NM_001081454.2) ENSMUST00000107362.1 ENSMUST00000107362.2 ENSMUST00000107362.3 ENSMUST00000107362.4 ENSMUST00000107362.5 ENSMUST00000107362.6 ENSMUST00000107362.7 ENSMUST00000107362.8 ENSMUST00000107362.9 FURIN_MOUSE Fur NM_001081454 P23188 Pcsk3 Q6GTN6 uc009iav.1 uc009iav.2 uc009iav.3 uc009iav.4 This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:18713856). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-45) (By similarity). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (PubMed:18713856). Reaction=Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.; EC=3.4.21.75; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 calcium ions per subunit. ; Inhibited by the not secondly cleaved propeptide. Inhibited by m-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)- benzamidine (m-guanidinomethyl-Phac-RVR-Amb) and 4-guanidinomethyl- phenylacetyl-Arg-Tle-Arg-4-amidinobenzylamide (MI-1148). Inhibited by Decanoyl-Arg-Val-Lys-Arg-chloromethylketone (decanoyl-RVKR-CMK). Inhibited by heparin/heparan sulfate-binding. Interacts with FLNA (PubMed:9412467). Binds to PACS1 which mediates TGN localization and connection to clathrin adapters (By similarity). Golgi apparatus, trans-Golgi network membrane ; Single-pass type I membrane protein Cell membrane ; Single- pass type I membrane protein Secreted Endosome membrane ; Single-pass type I membrane protein Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin. Seems to be expressed ubiquitously (PubMed:2266110). Expressed in islets of Langerhans (PubMed:18713856). Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface. The inhibition peptide, which plays the role of an intramolecular chaperone, is autocatalytically removed in the endoplasmic reticulum (ER) and remains non-covalently bound to furin as a potent autoinhibitor. Following transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation. Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono- and non-phosphorylated forms. Conditional knockout in pancreas causes mild glucose intolerance (PubMed:18713856). Insulin secretion by islets of Langerhans cells is reduced (PubMed:18713856). In islets of Langerhans cells, processing of pro-proteins including Pcsk2, Ins2/proinsulin II and Gcg/proglucagon and acidification of dense-core secretory granules are reduced (PubMed:18713856). Islets of Langerhans are normal (PubMed:18713856). Belongs to the peptidase S8 family. Furin subfamily. Golgi membrane protease binding endopeptidase activity serine-type endopeptidase activity serine-type endopeptidase inhibitor activity protein binding extracellular region endosome early endosome endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane Golgi apparatus trans-Golgi network plasma membrane signal peptide processing proteolysis peptidase activity serine-type peptidase activity regulation of signal transduction cell surface endosome membrane negative regulation of endopeptidase activity trans-Golgi network transport vesicle membrane membrane integral component of membrane protein processing peptide hormone processing hydrolase activity viral life cycle trans-Golgi network transport vesicle integral component of Golgi membrane positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway zymogen activation Golgi cisterna negative regulation of low-density lipoprotein particle receptor catabolic process nerve growth factor production negative regulation of transforming growth factor beta1 production secretion by cell regulation of protein catabolic process peptide binding peptide biosynthetic process membrane raft regulation of low-density lipoprotein particle receptor biosynthetic process metal ion binding nerve growth factor binding regulation of endopeptidase activity dibasic protein processing zymogen inhibition positive regulation of transforming growth factor beta1 activation uc009iav.1 uc009iav.2 uc009iav.3 uc009iav.4 
ENSMUST00000107363.3 Kcnh4 ENSMUST00000107363.3 The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. (from UniProt A2A5F7) A2A5F7 A2A5F7_MOUSE BC150990 ENSMUST00000107363.1 ENSMUST00000107363.2 Kcnh4 uc288cfo.1 uc288cfo.2 The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Membrane ; Multi- pass membrane protein ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity integral component of plasma membrane ion transport potassium ion transport membrane integral component of membrane regulation of ion transmembrane transport regulation of membrane potential transmembrane transport potassium ion transmembrane transport uc288cfo.1 uc288cfo.2 
ENSMUST00000107364.8 Rab5c ENSMUST00000107364.8 RAB5C, member RAS oncogene family, transcript variant 1 (from RefSeq NM_024456.5) ENSMUST00000107364.1 ENSMUST00000107364.2 ENSMUST00000107364.3 ENSMUST00000107364.4 ENSMUST00000107364.5 ENSMUST00000107364.6 ENSMUST00000107364.7 NM_024456 Q3TJ39 Q3TJ39_MOUSE Rab5C Rab5c uc007lme.1 uc007lme.2 uc007lme.3 uc007lme.4 Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding uc007lme.1 uc007lme.2 uc007lme.3 uc007lme.4 
ENSMUST00000107366.2 Trim32 ENSMUST00000107366.2 tripartite motif-containing 32, transcript variant 2 (from RefSeq NM_001161782.1) ENSMUST00000107366.1 NM_001161782 Q8CH72 Q8K055 TRI32_MOUSE uc008thr.1 uc008thr.2 uc008thr.3 uc008thr.4 Has an E3 ubiquitin ligase activity (PubMed:14578165, PubMed:16816390). Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation (By similarity). May ubiquitinate BBS2 (By similarity). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (PubMed:14578165, PubMed:16816390)Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. It self-associates (By similarity). Interacts with DTNBP1 (By similarity). Interacts with PIAS4/PIASY upon treatment with UVB and TNF-alpha (PubMed:16816390). Interacts with AMBRA1; promoting activation of ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (By similarity). Q8CH72; Q8CJG1: Ago1; NbExp=2; IntAct=EBI-773837, EBI-2291996; Q8CH72; P01108: Myc; NbExp=2; IntAct=EBI-773837, EBI-1183114; Cytoplasm te=Localized in cytoplasmic bodies, often located around the nucleus. Ubiquitous. High expression in brain. By interferon alpha/UVB treatment. Ubiquitinated. Belongs to the TRIM/RBCC family. protein polyubiquitination tissue homeostasis RNA binding ubiquitin-protein transferase activity protein binding nucleus cytoplasm striated muscle myosin thick filament ubiquitin-dependent protein catabolic process actin ubiquitination zinc ion binding response to UV protein ubiquitination transferase activity myosin binding positive regulation of cell growth positive regulation of cell migration translation initiation factor binding negative regulation of viral transcription response to tumor necrosis factor identical protein binding positive regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding protein self-association innate immune response fat cell differentiation positive regulation of neuron differentiation positive regulation of protein catabolic process positive regulation of cell cycle positive regulation of proteolysis muscle cell cellular homeostasis metal ion binding negative regulation of fibroblast proliferation positive regulation of neurogenesis positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of striated muscle cell differentiation axon development ubiquitin protein ligase activity negative regulation of keratinocyte apoptotic process negative regulation of viral release from host cell negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of interleukin-17-mediated signaling pathway positive regulation of chemokine (C-C motif) ligand 20 production positive regulation of cell motility uc008thr.1 uc008thr.2 uc008thr.3 uc008thr.4 
ENSMUST00000107372.8 Tnc ENSMUST00000107372.8 tenascin C, transcript variant 1 (from RefSeq NM_001369211.1) ENSMUST00000107372.1 ENSMUST00000107372.2 ENSMUST00000107372.3 ENSMUST00000107372.4 ENSMUST00000107372.5 ENSMUST00000107372.6 ENSMUST00000107372.7 Hxb NM_001369211 Q64706 Q80YX1 Q80YX2 TENA_MOUSE Tnc uc290nez.1 uc290nez.2 Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity). Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4 (By similarity). Interacts (via the 3rd fibronectin type-III domain) with integrin ITGA9:ITGB1 (PubMed:22654117). Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q80YX1-1; Sequence=Displayed; Name=2 ; IsoId=Q80YX1-2; Sequence=VSP_052147; Name=3 ; IsoId=Q80YX1-3; Sequence=VSP_052146; Name=4 ; IsoId=Q80YX1-4; Sequence=VSP_052145; Name=5 ; IsoId=Q80YX1-5; Sequence=VSP_052144; Expressed in the corneal limbus, the periosteum and the rib molecular layer of the cerebellum, the matrix of kidney tubules, blood vessels, stomach and intestine (at protein level). [Isoform 2]: Weakly expressed in the brain. [Isoform 5]: Highly expressed in the thymus and moderately expressed in the brain. At 11.5 dpc, expressed in maxillary process (at protein level) (PubMed:14709716). Expressed in the stomach and periosteum of the ribs at 14.5 and 15.5 dpc (at protein level) (PubMed:14709716). Expressed in developing bones such as the mandible, palate and teeth at 16.5 dpc (at protein level) (PubMed:14709716). Expressed in the smooth muscle layer of the stomach and mesenchyme of the lung at 16.5 dpc (at protein level) (PubMed:22654117). [Isoform 2]: Expressed in the intestine at 13 dpc (PubMed:1703162). Expressed in the cerebrum, cerebellum and stomach at 17 dpc and at 6 days of age (PubMed:1717349). Expression spreads to the duodenum, ileum, colon, bladder and skeletal muscle at 6 days of age (PubMed:1717349). Expressed in the kidney at birth (PubMed:1703162). [Isoform 5]: Expressed in the cerebellum at 17 dpc, expression is decreased at 6 days of age (PubMed:1717349). Expressed in the thymus, stomach and weakly in skeletal muscle at 17 dpc (PubMed:1717349). Expressed in the intestine at birth (PubMed:1703162). Expressed in the thymus, stomach, duodenum, ileum, colon, bladder and skeletal muscle at 6 days of age (PubMed:1717349). Expressed in the kidney at 2 weeks of age (PubMed:1703162). Expressed in the thymus and colon at 32 days of age (PubMed:1717349). N-glycosylated. Mice show enhanced novelty-induced activity, reduced anxiety, delayed resynchronization to daylight reversal and weaker muscle strength. Belongs to the tenascin family. fibronectin binding extracellular matrix structural constituent extracellular region basement membrane interstitial matrix extracellular space cell adhesion negative regulation of cell adhesion neuromuscular junction development positive regulation of cell proliferation response to wounding response to mechanical stimulus positive regulation of gene expression peripheral nervous system axon regeneration extracellular matrix neuron projection development wound healing regulation of cell proliferation odontogenesis of dentin-containing tooth response to ethanol syndecan binding bud outgrowth involved in lung branching mesenchymal-epithelial cell signaling involved in prostate gland development prostate gland epithelium morphogenesis cellular response to retinoic acid cellular response to vitamin D response to fibroblast growth factor cellular response to prostaglandin D stimulus perisynaptic extracellular matrix uc290nez.1 uc290nez.2 
ENSMUST00000107376.8 Nkiras2 ENSMUST00000107376.8 Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). (from UniProt Q9CR56) BC013469 ENSMUST00000107376.1 ENSMUST00000107376.2 ENSMUST00000107376.3 ENSMUST00000107376.4 ENSMUST00000107376.5 ENSMUST00000107376.6 ENSMUST00000107376.7 KBRS2_MOUSE Q8BWG0 Q9CR56 uc288cey.1 uc288cey.2 Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo (By similarity). Cytoplasm In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins. Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. nucleotide binding GTPase activity GTP binding cytoplasm I-kappaB kinase/NF-kappaB signaling uc288cey.1 uc288cey.2 
ENSMUST00000107384.10 Idh2 ENSMUST00000107384.10 isocitrate dehydrogenase 2 (NADP+), mitochondrial (from RefSeq NM_173011.2) ENSMUST00000107384.1 ENSMUST00000107384.2 ENSMUST00000107384.3 ENSMUST00000107384.4 ENSMUST00000107384.5 ENSMUST00000107384.6 ENSMUST00000107384.7 ENSMUST00000107384.8 ENSMUST00000107384.9 IDHP_MOUSE NM_173011 P54071 Q8C2R9 Q9EQK1 uc009hzn.1 uc009hzn.2 uc009hzn.3 uc009hzn.4 uc009hzn.5 uc009hzn.6 Plays a role in intermediary metabolism and energy production (PubMed:8867815). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:8867815). Reaction=D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH; Xref=Rhea:RHEA:19629, ChEBI:CHEBI:15562, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.42; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit. ; Homodimer. Mitochondrion Predominantly expressed in heart, liver and kidney (PubMed:8867815, PubMed:11278619). Expressed in activated B lymphocytes (PubMed:8867815). Up-regulated in activated B lymphocytes. By oxidative stress (at protein level). Acetylation at Lys-413 dramatically reduces catalytic activity. Deacetylated by SIRT3 (By similarity). Belongs to the isocitrate and isopropylmalate dehydrogenases family. Sequence=AAC52473.1; Type=Frameshift; Evidence=; magnesium ion binding isocitrate dehydrogenase activity isocitrate dehydrogenase (NADP+) activity mitochondrion mitochondrial inner membrane peroxisome cytosol glyoxylate cycle tricarboxylic acid cycle isocitrate metabolic process 2-oxoglutarate metabolic process NADP metabolic process NADP biosynthetic process oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor metal ion binding NAD binding oxidation-reduction process negative regulation of glial cell proliferation negative regulation of glial cell migration negative regulation of matrix metallopeptidase secretion uc009hzn.1 uc009hzn.2 uc009hzn.3 uc009hzn.4 uc009hzn.5 uc009hzn.6 
ENSMUST00000107389.8 Acly ENSMUST00000107389.8 ATP citrate lyase, transcript variant 1 (from RefSeq NM_001199296.1) Acly ENSMUST00000107389.1 ENSMUST00000107389.2 ENSMUST00000107389.3 ENSMUST00000107389.4 ENSMUST00000107389.5 ENSMUST00000107389.6 ENSMUST00000107389.7 NM_001199296 Q3V117 Q3V117_MOUSE uc007llm.1 uc007llm.2 uc007llm.3 uc007llm.4 Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. Reaction=acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA; Xref=Rhea:RHEA:21160, ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:456216; EC=2.3.3.8; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21162; Evidence=; Homotetramer. In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. nucleotide binding catalytic activity ATP citrate synthase activity ATP binding nucleoplasm cytoplasm cytosol plasma membrane acetyl-CoA biosynthetic process citrate metabolic process oxaloacetate metabolic process lipid metabolic process lipid biosynthetic process transferase activity metal ion binding transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer cofactor binding uc007llm.1 uc007llm.2 uc007llm.3 uc007llm.4 
ENSMUST00000107392.8 Anpep ENSMUST00000107392.8 alanyl aminopeptidase, membrane (from RefSeq NM_008486.3) AMPN_MOUSE ENSMUST00000107392.1 ENSMUST00000107392.2 ENSMUST00000107392.3 ENSMUST00000107392.4 ENSMUST00000107392.5 ENSMUST00000107392.6 ENSMUST00000107392.7 Lap-1 Lap1 NM_008486 P97449 Q91YH8 Q99K63 uc009hze.1 uc009hze.2 uc009hze.3 Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells (PubMed:8691132). May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (PubMed:22677001). Reaction=Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.; EC=3.4.11.2; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Homodimer (By similarity). Interacts with SLC6A19 (PubMed:22677001). Cell membrane ; Single-pass type II membrane protein Note=Also found as a soluble form. Expressed in the intestinal brush border (at protein level) (PubMed:22677001). Highly expressed in intestinal tract and kidney, present in liver, lymph node, spleen, and brain (PubMed:8805662, PubMed:8103749). Found as well in monocytes, macrophages, dendritic cells, veiled cells and B-cells but not on T- cells and thymocytes (PubMed:8103749). N- and O-glycosylated. Sulfated. May undergo proteolysis and give rise to a soluble form. Belongs to the peptidase M1 family. angiogenesis aminopeptidase activity extracellular space cytoplasm endoplasmic reticulum-Golgi intermediate compartment plasma membrane proteolysis multicellular organism development peptidase activity metallopeptidase activity zinc ion binding external side of plasma membrane membrane integral component of membrane hydrolase activity cell differentiation brush border membrane negative regulation of renal sodium excretion peptide binding peptide catabolic process metal ion binding metalloaminopeptidase activity extracellular exosome uc009hze.1 uc009hze.2 uc009hze.3 
ENSMUST00000107394.3 Mesp2 ENSMUST00000107394.3 mesoderm posterior 2 (from RefSeq NM_008589.2) A6H5V4 A6H5V4_MOUSE ENSMUST00000107394.1 ENSMUST00000107394.2 Mesp2 NM_008589 uc009hzc.1 uc009hzc.2 uc009hzc.3 transcription factor activity, sequence-specific DNA binding regulation of transcription, DNA-templated protein dimerization activity uc009hzc.1 uc009hzc.2 uc009hzc.3 
ENSMUST00000107409.5 Mfge8 ENSMUST00000107409.5 milk fat globule EGF and factor V/VIII domain containing, transcript variant 2 (from RefSeq NM_001045489.1) ENSMUST00000107409.1 ENSMUST00000107409.2 ENSMUST00000107409.3 ENSMUST00000107409.4 MFGM_MOUSE NM_001045489 P21956 P97800 Q3TBN5 Q3U8S9 Q9R1X9 Q9WTS3 uc009hyb.1 uc009hyb.2 uc009hyb.3 Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction (By similarity). Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. Membrane ; Peripheral membrane protein Secreted Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Peripheral membrane protein Note=Located in the acrosomal region of zona-pellucida bound sperm. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=P21956-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P21956-2; Sequence=VSP_009880; Mammary epithelial cell surfaces and spermatozoan. Isoform 2 is present in brain, heart, kidney and spleen and at low levels in lung, liver, small intestine and testis. Isoform 1 and isoform 2 are detectable in mammary tissue from non-pregnant animals, with isoform 2 being predominant. Levels of isoform 1 increase during gestation and lactation while levels of isoform 2 decrease. Isoform 1 is induced by insulin, prolactin and hydrocortisone in mammary epithelial cells. Expression of isoform 2 is repressed by the same treatment. The F5/8 type C 2 domain mediates high-affinity binding to phosphatidylserine-containing membranes. N-glycosylated. Isoform 1 also exists in both an O-glycosylated and a non-O-glycosylated form. angiogenesis phosphatidylserine binding integrin binding extracellular matrix structural constituent extracellular region extracellular space phagocytosis, recognition phagocytosis, engulfment cell adhesion single fertilization phosphatidylethanolamine binding external side of plasma membrane membrane extrinsic component of plasma membrane apoptotic cell clearance positive regulation of phagocytosis uc009hyb.1 uc009hyb.2 uc009hyb.3 
ENSMUST00000107411.3 Krt15 ENSMUST00000107411.3 keratin 15 (from RefSeq NM_008469.2) B1AQ77 B1AQ77_MOUSE ENSMUST00000107411.1 ENSMUST00000107411.2 Krt15 NM_008469 uc007lkk.1 uc007lkk.2 uc007lkk.3 uc007lkk.4 Belongs to the intermediate filament family. structural molecule activity intermediate filament scaffold protein binding uc007lkk.1 uc007lkk.2 uc007lkk.3 uc007lkk.4 
ENSMUST00000107415.8 Zfp618 ENSMUST00000107415.8 zinc finger protein 618, transcript variant 1 (from RefSeq NM_028327.1) ENSMUST00000107415.1 ENSMUST00000107415.2 ENSMUST00000107415.3 ENSMUST00000107415.4 ENSMUST00000107415.5 ENSMUST00000107415.6 ENSMUST00000107415.7 Kiaa1952 NM_028327 Q69Z57 Q80YY7 Q80YY8 Q9CZ99 ZN618_MOUSE Znf618 uc008tfo.1 uc008tfo.2 uc008tfo.3 uc008tfo.4 Regulates UHRF2 function as a specific 5- hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization. Interacts with UHRF2. Nucleus Chromosome Note=Localizes at genomic loci that are enriched for 5-hydroxymethylcytosine (5hmC). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80YY7-1; Sequence=Displayed; Name=2; IsoId=Q80YY7-2; Sequence=VSP_025186, VSP_025184, VSP_025185; Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAB28510.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding nucleus biological_process metal ion binding uc008tfo.1 uc008tfo.2 uc008tfo.3 uc008tfo.4 
ENSMUST00000107416.3 Krt36 ENSMUST00000107416.3 keratin 36 (from RefSeq NM_001174099.1) B1AQ75 ENSMUST00000107416.1 ENSMUST00000107416.2 Hra-1 KRT36_MOUSE Krt1-22 Krt1-5 Krt36 NM_001174099 Q61861 uc011yey.1 uc011yey.2 uc011yey.3 uc011yey.4 Heterotetramer of two type I and two type II keratins. In skin, only expressed in the suprabasal cells of tail scale epidermis. Suprabasally expressed in stratified squamous epithelia and also in the posterior unit of the complex filiform papillae of tongue. Expressed in rare anatomical sites in which an orthokeratinized stratum corneum would be too soft and a hard keratinized structure would be too rigid to meet the functional requirement of the respective epithelia. mRNA synthesis is suppressed during retinoic acid-mediated orthokeratotic conversion of tail scale epidermis. There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). Belongs to the intermediate filament family. Sequence=CAA46480.1; Type=Frameshift; Evidence=; structural molecule activity intermediate filament structural constituent of epidermis intermediate filament cytoskeleton regulation of keratinocyte differentiation uc011yey.1 uc011yey.2 uc011yey.3 uc011yey.4 
ENSMUST00000107419.3 Krt32 ENSMUST00000107419.3 keratin 32 (from RefSeq NM_001159374.3) B1ATJ5 B1ATJ5_MOUSE ENSMUST00000107419.1 ENSMUST00000107419.2 Krt32 NM_001159374 uc007lkf.1 uc007lkf.2 uc007lkf.3 uc007lkf.4 uc007lkf.5 Belongs to the intermediate filament family. structural molecule activity intermediate filament uc007lkf.1 uc007lkf.2 uc007lkf.3 uc007lkf.4 uc007lkf.5 
ENSMUST00000107425.8 Aen ENSMUST00000107425.8 apoptosis enhancing nuclease, transcript variant 1 (from RefSeq NM_026531.5) AEN_MOUSE ENSMUST00000107425.1 ENSMUST00000107425.2 ENSMUST00000107425.3 ENSMUST00000107425.4 ENSMUST00000107425.5 ENSMUST00000107425.6 ENSMUST00000107425.7 Isg20l1 NM_026531 Q3TKV9 Q8BTJ8 Q8C095 Q9CZI9 uc009hxp.1 uc009hxp.2 uc009hxp.3 Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single- stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (By similarity). Nucleus Nucleus, nucleolus Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZI9-1; Sequence=Displayed; Name=2; IsoId=Q9CZI9-2; Sequence=VSP_032133; Sequence=BAC27632.1; Type=Erroneous initiation; Evidence=; DNA catabolic process, exonucleolytic nucleic acid binding nuclease activity exonuclease activity nucleus nucleoplasm nucleolus RNA catabolic process apoptotic process cellular response to DNA damage stimulus response to ionizing radiation hydrolase activity nuclear membrane intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of viral genome replication defense response to virus uc009hxp.1 uc009hxp.2 uc009hxp.3 
ENSMUST00000107434.2 Krtap9-21 ENSMUST00000107434.2 predicted gene 11568 (from RefSeq NM_001205030.1) A2A4M2 A2A4M2_MOUSE ENSMUST00000107434.1 Gm11568 NM_001205030 uc029roc.1 uc029roc.2 uc029roc.3 molecular_function cellular_component intermediate filament biological_process keratin filament uc029roc.1 uc029roc.2 uc029roc.3 
ENSMUST00000107437.2 Krtap4-16 ENSMUST00000107437.2 keratin associated protein 4-16 (from RefSeq NM_001013823.1) ENSMUST00000107437.1 Krtap4-16 NM_001013823 OTTMUSG00000002196 Q91W93 Q91W93_MOUSE uc007lju.1 uc007lju.2 uc007lju.3 molecular_function cellular_component intermediate filament aging hair cycle keratin filament uc007lju.1 uc007lju.2 uc007lju.3 
ENSMUST00000107439.2 Krtap4-8 ENSMUST00000107439.2 keratin associated protein 4-8 (from RefSeq NM_001085547.2) B1AQA8 B1AQA8_MOUSE ENSMUST00000107439.1 Krtap4-8 NM_001085547 uc007ljm.1 uc007ljm.2 uc007ljm.3 uc007ljm.4 molecular_function cellular_component intermediate filament biological_process keratin filament uc007ljm.1 uc007ljm.2 uc007ljm.3 uc007ljm.4 
ENSMUST00000107440.2 Krtap4-22 ENSMUST00000107440.2 predicted gene 11595 (from RefSeq NM_001126322.1) B1AQA7 B1AQA7_MOUSE ENSMUST00000107440.1 Gm11595 NM_001126322 uc011yes.1 uc011yes.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc011yes.1 uc011yes.2 
ENSMUST00000107445.8 Krt39 ENSMUST00000107445.8 keratin 39 (from RefSeq NM_213730.3) A2VCT4 ENSMUST00000107445.1 ENSMUST00000107445.2 ENSMUST00000107445.3 ENSMUST00000107445.4 ENSMUST00000107445.5 ENSMUST00000107445.6 ENSMUST00000107445.7 K1C39_MOUSE Ka35 NM_213730 Q0VDS4 Q6IFX4 uc288cbs.1 uc288cbs.2 May play a role in late hair differentiation. Heterotetramer of two type I and two type II keratins. There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively). Belongs to the intermediate filament family. Sequence=DAA04489.1; Type=Erroneous gene model prediction; Evidence=; structural molecule activity intermediate filament biological_process uc288cbs.1 uc288cbs.2 
ENSMUST00000107449.4 Bspry ENSMUST00000107449.4 B-box and SPRY domain containing, transcript variant 2 (from RefSeq NM_001368623.1) BSPRY_MOUSE ENSMUST00000107449.1 ENSMUST00000107449.2 ENSMUST00000107449.3 NM_001368623 Q3TU74 Q80YW5 Q8BZF0 Q99KV7 Q9ER70 uc008tex.1 uc008tex.2 uc008tex.3 May regulate epithelial calcium transport by inhibiting TRPV5 activity. Interacts with YWHAZ/14-3-3 protein zeta (By similarity). Interacts with TRPV5 and TRPV6. Cytoplasm Membrane ; Peripheral membrane protein Note=Apical domain of kidney distal tubular cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80YW5-1; Sequence=Displayed; Name=2; IsoId=Q80YW5-2; Sequence=VSP_019529; According to PubMed:10978534, testis-specific. According to PubMed:16371431, broadly expressed. Expression starts at 19 dpc in brain. Down-regulated by vitamin D. vitamin D binding cytoplasm ion transport calcium ion transport zinc ion binding membrane cell leading edge metal ion binding perinuclear region of cytoplasm cellular response to leukemia inhibitory factor uc008tex.1 uc008tex.2 uc008tex.3 
ENSMUST00000107455.8 Rnf183 ENSMUST00000107455.8 ring finger protein 183, transcript variant 2 (from RefSeq NM_153504.4) B7ZCH3 ENSMUST00000107455.1 ENSMUST00000107455.2 ENSMUST00000107455.3 ENSMUST00000107455.4 ENSMUST00000107455.5 ENSMUST00000107455.6 ENSMUST00000107455.7 NM_153504 Q5NBV8 Q8QZS5 RN183_MOUSE uc290nct.1 uc290nct.2 Acts as an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29300766). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (By similarity). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with FATE1 (By similarity). Interacts with SEC16A (PubMed:29300766). Interacts with BCL2L1 (By similarity). Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Endoplasmic reticulum Golgi apparatus, cis-Golgi network membrane Lysosome membrane Highly expressed in the kidney and testis. Autoubiquitinated (in vitro). protein polyubiquitination protein binding lysosome lysosomal membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus apoptotic process membrane integral component of membrane protein ubiquitination transferase activity integral component of endoplasmic reticulum membrane cis-Golgi network membrane response to endoplasmic reticulum stress metal ion binding protein autoubiquitination ubiquitin protein ligase activity positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway uc290nct.1 uc290nct.2 
ENSMUST00000107456.4 Fam174b ENSMUST00000107456.4 family with sequence similarity 174, member B (from RefSeq NM_001162532.1) ENSMUST00000107456.1 ENSMUST00000107456.2 ENSMUST00000107456.3 F174B_MOUSE NM_001162532 Q2NLC2 Q8K064 uc009hrf.1 uc009hrf.2 uc009hrf.3 uc009hrf.4 Essential for Golgi structural integrity. Cell membrane ; Single-pass type I membrane protein Golgi apparatus Belongs to the FAM174 family. molecular_function cellular_component biological_process membrane integral component of membrane uc009hrf.1 uc009hrf.2 uc009hrf.3 uc009hrf.4 
ENSMUST00000107462.8 Dpm3 ENSMUST00000107462.8 Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the endoplasmic reticulum. (from UniProt Q9D1Q4) AK003223 DPM3_MOUSE ENSMUST00000107462.1 ENSMUST00000107462.2 ENSMUST00000107462.3 ENSMUST00000107462.4 ENSMUST00000107462.5 ENSMUST00000107462.6 ENSMUST00000107462.7 Q9D1Q4 uc033huv.1 uc033huv.2 uc033huv.3 Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the endoplasmic reticulum. Protein modification; protein glycosylation. Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; within the complex, associates with DPM1 via its C-terminal domain and with DPM2 via its N-terminal portion. This interaction stabilizes DPM1 protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the DPM3 family. dolichyl-phosphate beta-D-mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation GPI anchor biosynthetic process membrane integral component of membrane integral component of endoplasmic reticulum membrane regulation of protein stability dolichol-phosphate-mannose synthase complex mannosylation uc033huv.1 uc033huv.2 uc033huv.3 
ENSMUST00000107471.8 Ttc23 ENSMUST00000107471.8 tetratricopeptide repeat domain 23, transcript variant 5 (from RefSeq NM_001360653.1) E9QKU9 E9QKU9_MOUSE ENSMUST00000107471.1 ENSMUST00000107471.2 ENSMUST00000107471.3 ENSMUST00000107471.4 ENSMUST00000107471.5 ENSMUST00000107471.6 ENSMUST00000107471.7 NM_001360653 Ttc23 uc009hit.1 uc009hit.2 uc009hit.3 uc009hit.4 uc009hit.1 uc009hit.2 uc009hit.3 uc009hit.4 
ENSMUST00000107474.8 Rara ENSMUST00000107474.8 Nucleus (from UniProt Q3U3R3) BC010216 ENSMUST00000107474.1 ENSMUST00000107474.2 ENSMUST00000107474.3 ENSMUST00000107474.4 ENSMUST00000107474.5 ENSMUST00000107474.6 ENSMUST00000107474.7 Q3U3R3 Q3U3R3_MOUSE Rara uc288cam.1 uc288cam.2 Nucleus Belongs to the nuclear hormone receptor family. NR1 subfamily. nuclear chromatin translation repressor activity, nucleic acid binding liver development retinoic acid binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity transcription corepressor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding nucleus cytoplasm cytosol regulation of transcription, DNA-templated protein phosphorylation signal transduction female pregnancy transcription factor binding drug binding zinc ion binding positive regulation of cell proliferation negative regulation of cell proliferation male gonad development actin cytoskeleton negative regulation of translation enzyme binding protein domain specific binding hippocampus development dendrite prostate gland development negative regulation of granulocyte differentiation chromatin DNA binding regulation of myelination response to estradiol response to retinoic acid negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production response to vitamin A response to cytokine signaling receptor activity histone deacetylase binding regulation of apoptotic process neuron projection apoptotic cell clearance steroid hormone mediated signaling pathway protein kinase B binding sequence-specific DNA binding retinoic acid-responsive element binding response to ethanol positive regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding protein heterodimerization activity mRNA 5'-UTR binding regulation of synaptic plasticity retinoic acid receptor signaling pathway perinuclear region of cytoplasm protein kinase A binding positive regulation of binding alpha-actinin binding cellular response to retinoic acid cellular response to estrogen stimulus uc288cam.1 uc288cam.2 
ENSMUST00000107479.3 Rapgefl1 ENSMUST00000107479.3 Rap guanine nucleotide exchange factor (GEF)-like 1 (from RefSeq NM_001080925.1) A1L3T1 ENSMUST00000107479.1 ENSMUST00000107479.2 NM_001080925 Q68EF8 RPGFL_MOUSE uc007lhr.1 uc007lhr.2 uc007lhr.3 Probable guanine nucleotide exchange factor (GEF). Sequence=AAI30267.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; guanyl-nucleotide exchange factor activity small GTPase mediated signal transduction uc007lhr.1 uc007lhr.2 uc007lhr.3 
ENSMUST00000107482.10 Pklr ENSMUST00000107482.10 pyruvate kinase liver and red blood cell, transcript variant 2 (from RefSeq NM_001099779.1) E9Q509 E9Q509_MOUSE ENSMUST00000107482.1 ENSMUST00000107482.2 ENSMUST00000107482.3 ENSMUST00000107482.4 ENSMUST00000107482.5 ENSMUST00000107482.6 ENSMUST00000107482.7 ENSMUST00000107482.8 ENSMUST00000107482.9 NM_001099779 Pklr uc008pxq.1 uc008pxq.2 uc008pxq.3 Reaction=ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate; Xref=Rhea:RHEA:18157, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58702, ChEBI:CHEBI:456216; EC=2.7.1.40; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18159; Evidence=; Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence=; Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 5/5. Belongs to the pyruvate kinase family. magnesium ion binding catalytic activity pyruvate kinase activity glycolytic process kinase activity phosphorylation transferase activity potassium ion binding uc008pxq.1 uc008pxq.2 uc008pxq.3 
ENSMUST00000107483.8 Mup16 ENSMUST00000107483.8 major urinary protein 16 (from RefSeq NM_001199936.1) ENSMUST00000107483.1 ENSMUST00000107483.2 ENSMUST00000107483.3 ENSMUST00000107483.4 ENSMUST00000107483.5 ENSMUST00000107483.6 ENSMUST00000107483.7 MUP6_MOUSE Mup6 NM_001199936 P02762 P70119 Q78EF5 Q91V46 uc029uuw.1 uc029uuw.2 uc029uuw.3 uc029uuw.4 Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females. Secreted. Abundant in the urine of adult male mice but absent from that of females. Causes an allergic reaction in human. There are about 15 group 1 MUP genes and their transcripts make up about 5% of male mouse liver RNA. Belongs to the calycin superfamily. Lipocalin family. insulin-activated receptor activity pheromone binding extracellular region extracellular space nucleus cytosol energy reserve metabolic process insulin receptor signaling pathway aerobic respiration positive regulation of gene expression negative regulation of lipid storage positive regulation of glucose metabolic process heat generation small molecule binding glucose homeostasis locomotor rhythm negative regulation of gluconeogenesis positive regulation of lipid metabolic process negative regulation of transcription, DNA-templated negative regulation of lipid biosynthetic process positive regulation of protein kinase B signaling negative regulation of insulin secretion involved in cellular response to glucose stimulus mitochondrion morphogenesis cellular response to lipid uc029uuw.1 uc029uuw.2 uc029uuw.3 uc029uuw.4 
ENSMUST00000107484.2 Mup17 ENSMUST00000107484.2 major urinary protein 17 (from RefSeq NM_001200006.1) B5X0G2 ENSMUST00000107484.1 MUP17_MOUSE Mup15 NM_001200006 uc012dfm.1 uc012dfm.2 uc012dfm.3 uc012dfm.4 uc012dfm.5 Major urinary proteins (Mups) bind pheromones, thus stabilize them and allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance (By similarity). Secreted Because of their involvement in the coordination of social behavior, Mup proteins are thought to exhibit variable expression depending upon gender, age and status of the studied individuals. Expression may also be strain-specific: in strains C57BL/6J and 129S7, transcriptional support is lacking for Mup17. Belongs to the calycin superfamily. Lipocalin family. Mups are encoded by multiple paralogous genes which are very similar to each other, making accurate identification difficult. The recommended nomenclature used in this entry is based on that provided by the MGI database. molecular_function pheromone binding cellular_component extracellular region biological_process small molecule binding uc012dfm.1 uc012dfm.2 uc012dfm.3 uc012dfm.4 uc012dfm.5 
ENSMUST00000107498.9 Gon4l ENSMUST00000107498.9 gon-4 like, transcript variant 2 (from RefSeq NM_027389.4) E9Q507 E9Q507_MOUSE ENSMUST00000107498.1 ENSMUST00000107498.2 ENSMUST00000107498.3 ENSMUST00000107498.4 ENSMUST00000107498.5 ENSMUST00000107498.6 ENSMUST00000107498.7 ENSMUST00000107498.8 F8WGY9 Gon4l NM_027389 uc008pwz.1 uc008pwz.2 uc008pwz.3 uc008pwz.4 uc008pwz.5 Nucleus DNA binding transcription corepressor activity nucleus regulation of transcription, DNA-templated B cell differentiation negative regulation of transcription, DNA-templated uc008pwz.1 uc008pwz.2 uc008pwz.3 uc008pwz.4 uc008pwz.5 
ENSMUST00000107505.8 Syt11 ENSMUST00000107505.8 Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+) (Probable). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval (PubMed:29311685). Plays an important role in dopamine transmission by regulating endocytosis and the vesicle- recycling process (PubMed:29311685). Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity (PubMed:30808661). In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis (PubMed:28686317, PubMed:23303671). In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (PubMed:26450452). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822). (from UniProt Q9R0N3) BC054526 ENSMUST00000107505.1 ENSMUST00000107505.2 ENSMUST00000107505.3 ENSMUST00000107505.4 ENSMUST00000107505.5 ENSMUST00000107505.6 ENSMUST00000107505.7 Q7TQG8 Q9R0N3 SYT11_MOUSE Syt11 uc008pwm.1 uc008pwm.2 uc008pwm.3 Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+) (Probable). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval (PubMed:29311685). Plays an important role in dopamine transmission by regulating endocytosis and the vesicle- recycling process (PubMed:29311685). Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity (PubMed:30808661). In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis (PubMed:28686317, PubMed:23303671). In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (PubMed:26450452). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Homodimer. Can also form heterodimers. Interacts with PRKN (By similarity). Interacts (via C2 2 domain) with AGO2 and SND1; the interaction with SND1 is direct (PubMed:24882364). Interacts with KIF1A; the interaction increases in presence of calcium (PubMed:30808661). Q9R0N3; Q9JI51: Vti1a; Xeno; NbExp=2; IntAct=EBI-647443, EBI-7573650; Cytoplasmic vesicle membrane ; Single-pass membrane protein Perikaryon Golgi apparatus, trans-Golgi network membrane ; Single-pass membrane protein Recycling endosome membrane ; Single-pass membrane protein Lysosome membrane ingle-pass membrane protein Cytoplasmic vesicle, phagosome Cell projection, axon Cell projection, dendrite Postsynaptic density Recycling endosome membrane ; Single-pass membrane protein Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Single-pass membrane protein Perikaryon Note=Localized in vesicles that travels in axonal and dendritic shafts in both anterograde and retrograde directions (PubMed:30808661). In macrophages and microglia, recruited in phagosomes at early stages of phagocytosis (PubMed:28686317, PubMed:23303671). Expressed in cerebellun, cerebellar cortex, hippocampus, olfactory bulb and spinal cord (at protein level) (PubMed:30808661). Expressed by neurons, astrocytes and microglia (at protein level) (PubMed:28686317, PubMed:26450452). Expressed in macrophages (at protein level) (PubMed:23303671). Abundant across the brain, expression increases progressively over the first 2 weeks after birth. The second C2 domain/C2B is required for the inhibitory role in both clathrin-mediated and bulk endocytosis. The transmembrane domain and the first C2 domain/C2A are critical for the inhibitory role in clathrin-mediated endocytosis or bulk endocytosis, respectively. Unlike in other synaptotagmin family members, the first C2 domain/C2A does not bind Ca(2+) neither mediates Ca(2+)-dependent phospholipid binding. An aspartate-to-serine substitution in this domain inactivates Ca(2+)/phospho-lipid binding. Ubiquitinated, at least by PRKN, and targeted to the proteasome complex for degradation. Ubiquitination is inhibited by ATP13A2. Knockout is lethal (PubMed:30808661). Conditional knockout mice for dopaminergic neurons show increased dopamine release, accelerated vesicle pools replenishment and enlarged releasable vesicle pools in the striatum (PubMed:29311685). Forebrain-specific conditional knockouts are viable, fertile and have normal life span. They show impaired learning an memory (PubMed:30808661). Belongs to the synaptotagmin family. SNARE binding plasma membrane repair phosphatidylserine binding phagocytic cup calcium ion binding protein binding calcium-dependent phospholipid binding cytoplasm lysosome plasma membrane integral component of plasma membrane synaptic vesicle response to wounding regulation of dopamine secretion postsynaptic density membrane integral component of membrane vesicle-mediated transport calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis cell junction clathrin binding integral component of synaptic vesicle membrane axon synaptic vesicle membrane translation initiation factor binding cytoplasmic vesicle ubiquitin protein ligase binding vesicle early phagosome identical protein binding neuron projection terminal bouton dendritic spine cell body synapse phagocytic vesicle metal ion binding perinuclear region of cytoplasm beta-tubulin binding presynaptic active zone membrane negative regulation of phagocytosis recycling endosome excitatory synapse inhibitory synapse exocytic vesicle cellular response to calcium ion presynapse postsynapse integral component of presynaptic active zone membrane negative regulation of interleukin-6 secretion negative regulation of clathrin-dependent endocytosis negative regulation of synaptic vesicle endocytosis regulation of defense response to bacterium negative regulation of tumor necrosis factor secretion negative regulation of membrane invagination regulation of phagosome maturation positive regulation of protein localization to phagocytic vesicle negative regulation of clathrin-coated pit assembly calcium ion regulated lysosome exocytosis uc008pwm.1 uc008pwm.2 uc008pwm.3 
ENSMUST00000107517.8 Mup6 ENSMUST00000107517.8 major urinary protein 6 (from RefSeq NM_001081285.2) 620807 A2AV72 A2AV72_MOUSE CU075549.1-001 ENSMUST00000107517.1 ENSMUST00000107517.2 ENSMUST00000107517.3 ENSMUST00000107517.4 ENSMUST00000107517.5 ENSMUST00000107517.6 ENSMUST00000107517.7 Mup2 Mup6 NM_001081285 uc290naf.1 uc290naf.2 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc290naf.1 uc290naf.2 
ENSMUST00000107538.2 Cdk12 ENSMUST00000107538.2 cyclin dependent kinase 12, transcript variant 1 (from RefSeq NM_001109626.1) A2A530 A2A531 B1AQH7 CDK12_MOUSE Crk7 Crkrs ENSMUST00000107538.1 Kiaa0904 NM_001109626 Q14AX6 Q6ZQ27 Q8R457 uc007lft.1 uc007lft.2 uc007lft.3 uc007lft.4 Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. Reaction=[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho- [DNA-directed RNA polymerase]; Xref=Rhea:RHEA:10216, Rhea:RHEA- COMP:11321, Rhea:RHEA-COMP:11322, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.23; Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Interacts with CCNL1 and CCNL2. Nucleus Nucleus speckle Note=Colocalized with nuclear speckles throughout interphase. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14AX6-1; Sequence=Displayed; Name=2; IsoId=Q14AX6-2; Sequence=VSP_030285, VSP_030287; Name=3; IsoId=Q14AX6-3; Sequence=VSP_030286; Phosphorylation at Thr-889 increases kinase activity. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Sequence=CAM21270.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding cyclin-dependent protein kinase holoenzyme complex nuclear chromatin fibrillar center cyclin K-CDK12 complex protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus mRNA processing protein phosphorylation RNA polymerase II carboxy-terminal domain kinase activity RNA splicing kinase activity phosphorylation nuclear speck transferase activity protein kinase binding nuclear cyclin-dependent protein kinase holoenzyme complex cyclin binding positive regulation of transcription elongation from RNA polymerase II promoter regulation of MAP kinase activity regulation of RNA splicing protein autophosphorylation regulation of cell cycle phosphorylation of RNA polymerase II C-terminal domain negative regulation of stem cell differentiation uc007lft.1 uc007lft.2 uc007lft.3 uc007lft.4 
ENSMUST00000107543.8 Bglap3 ENSMUST00000107543.8 bone gamma-carboxyglutamate protein 3, transcript variant 4 (from RefSeq NM_001305450.1) Bglap-rs1 Bglap3 ENSMUST00000107543.1 ENSMUST00000107543.2 ENSMUST00000107543.3 ENSMUST00000107543.4 ENSMUST00000107543.5 ENSMUST00000107543.6 ENSMUST00000107543.7 NM_001305450 OSTR_MOUSE P54615 Q78H72 uc056zte.1 uc056zte.2 uc056zte.3 Binds strongly to apatite and calcium. Secreted Expressed in kidney and lung, but not in bone. Gamma-carboxyglutamic acid residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. Belongs to the osteocalcin/matrix Gla protein family. ossification osteoblast differentiation calcium ion binding extracellular region extracellular space cytoplasm rough endoplasmic reticulum Golgi apparatus structural constituent of bone dendrite regulation of bone mineralization biomineral tissue development vesicle response to vitamin K cell projection perikaryon hydroxyapatite binding metal ion binding bone development regulation of cellular response to insulin stimulus uc056zte.1 uc056zte.2 uc056zte.3 
ENSMUST00000107545.9 Med1 ENSMUST00000107545.9 mediator complex subunit 1, transcript variant 5 (from RefSeq NM_001361951.2) A2A526 A2A528 Crsp210 Drip205 ENSMUST00000107545.1 ENSMUST00000107545.2 ENSMUST00000107545.3 ENSMUST00000107545.4 ENSMUST00000107545.5 ENSMUST00000107545.6 ENSMUST00000107545.7 ENSMUST00000107545.8 MED1_MOUSE NM_001361951 O88323 Pbp Pparbp Q3UHV0 Q6AXD5 Q8BW37 Q8BX19 Q8VDQ7 Q925J9 Q925K0 Trap220 Trip2 uc007lfq.1 uc007lfq.2 uc007lfq.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Essential for embryogenesis, including development of the central nervous system, heart, liver and placenta and for erythropoiesis. Also required for normal transcriptional control of thyroid-stimulating hormone beta (TSHB) in the pituitary. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. This subunit specifically interacts with a number of nuclear receptors in a ligand-dependent fashion including AR, ESR1, ESR2, PPARA, PPARG, RORA, RXRA, RXRG, THRA, THRB and VDR. Interacts with CTNNB1, GABPA, GLI3, PPARGC1A and TP53. Interacts with GATA1 and YWHAH. Interacts with CLOCK; this interaction requires the presence of THRAP3. Interacts with CCAR1 (By similarity). Interacts with NR4A3 (PubMed:12709428). Interacts (via IBM motif) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (By similarity). Nucleus Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3. Event=Alternative splicing; Named isoforms=4; Name=1 ; IsoId=Q925J9-1; Sequence=Displayed; Name=2 ; IsoId=Q925J9-2; Sequence=VSP_051893, VSP_051896; Name=3 ; IsoId=Q925J9-3; Sequence=VSP_051894, VSP_051895; Name=4 ; IsoId=Q925J9-4; Sequence=VSP_051892; Widely expressed in the adult, with high levels of expression in the liver, lung, intestinal mucosa, kidney cortex, thymic cortex, splenic follicle and seminiferous epithelium in testis. Also expressed in the adult heart, brain, spleen and skeletal muscle. Widely expressed during embryonic development; at stages 9.5 dpc-10.5 dpc, expression is strongest in neural tissues. At 11.5 dpc-12.5 dpc, expression is abundant throughout embryonic tissues, being strongest in the developing liver, primitive gut, nasopharynx, and developing limb buds. Moderately expressed at this stage in the brain and optic stalk, branchial arch and urogential ridge. Expressed at a low level in the heart. By stage 13.5 dpc-14.5 dpc, expression is abundant in the forebrain, vagus nerve, dorsal root ganglia, nasopharynx, kidney, liver, pancreas, intestine, gut, thymus, lung, genital tubercle, tongue and lower jaw. Moderately expressed in the midbrain and expressed at a low level in the heart and large blood vessels. In the developing placenta, expression is moderate in the giant and spongiotrophoblast cell layers and strongest in the labyrinthine portion throughout 9.5 dpc-13.5 dpc. Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus (By similarity). Phosphorylation increases its interaction with PSIP1 (By similarity). Belongs to the Mediator complex subunit 1 family. Sequence=AAH21440.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter ubiquitin ligase complex chromatin cell morphogenesis RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding angiogenesis in utero embryonic development liver development embryonic placenta development lens development in camera-type eye thyroid hormone mediated signaling pathway ventricular trabecula myocardium morphogenesis retinal pigment epithelium development DNA binding chromatin binding transcription cofactor activity transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm nucleolus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase I promoter regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter thyroid hormone generation protein import into nucleus androgen biosynthetic process multicellular organism development brain development heart development lactation transcription factor binding positive regulation of cell proliferation animal organ morphogenesis positive regulation of gene expression negative regulation of keratinocyte proliferation protein ubiquitination mediator complex ligand-dependent nuclear receptor binding keratinocyte differentiation monocyte differentiation estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity thyroid hormone receptor coactivator activity intracellular steroid hormone receptor signaling pathway animal organ regeneration chromatin DNA binding protein-DNA complex positive regulation of intracellular estrogen receptor signaling pathway mammary gland epithelial cell proliferation embryonic heart tube development embryonic hindlimb morphogenesis embryonic hemopoiesis nuclear hormone receptor binding peroxisome proliferator activated receptor signaling pathway cellular response to hepatocyte growth factor stimulus megakaryocyte development mediator complex binding mRNA transcription from RNA polymerase II promoter vitamin D receptor binding retinoic acid receptor binding peroxisome proliferator activated receptor binding camera-type eye development negative regulation of apoptotic process macromolecular complex binding fat cell differentiation positive regulation of keratinocyte differentiation positive regulation of erythrocyte differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter thyroid hormone receptor binding erythrocyte development enucleate erythrocyte development LBD domain binding positive regulation of interferon-gamma-mediated signaling pathway mammary gland branching involved in thelarche mammary gland branching involved in pregnancy epithelial cell proliferation involved in mammary gland duct elongation ubiquitin protein ligase activity positive regulation of G0 to G1 transition ERK1 and ERK2 cascade regulation of vitamin D receptor signaling pathway cellular response to epidermal growth factor stimulus cellular response to steroid hormone stimulus cellular response to thyroid hormone stimulus positive regulation of receptor activity positive regulation of hepatocyte proliferation regulation of RNA biosynthetic process uc007lfq.1 uc007lfq.2 uc007lfq.3 
ENSMUST00000107547.2 Shoc1 ENSMUST00000107547.2 shortage in chiasmata 1 (from RefSeq NM_001370843.1) A2ALV5 ENSMUST00000107547.1 NM_001370843 SHOC1_MOUSE Shoc1 Zip2 uc290myt.1 uc290myt.2 ATPase required during meiosis for the formation of crossover recombination intermediates (PubMed:29742103). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (By similarity). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (By similarity). Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells (PubMed:30272023). Required for proper synaptonemal complex assembly and homologous chromosome pairing (PubMed:35485979). Required for recruitment of TEX11 and MSH4 to recombination intermediates (PubMed:30272023). Interacts with TEX11 (By similarity). Interacts with SPO16 (PubMed:30746471). Chromosome Note=Localizes to meiotic chromosomes; associates with mid-stage meiotic recombination intermediates (PubMed:29742103). Localization requires meiotic double-strand breaks (DSBs) recombination intermediates catalyzed by DMC1 (PubMed:29742103). Mainly expressed in adult testis. Expressed in embryonic ovaries at embryonic day 16.5. Mice show severe defects in meiotic prophase I, such as DNA double-strand break (DSB) repair, crossover formation and synapsis in spermatocytes and oocytes resulting in sterility in both male and females (PubMed:30272023). Embryonic lethality due to defects in meiosis (PubMed:29742103). The use of a hypomorphic allele showed that spermatogenesis progresses normally until the end of prophase I when spermatocytes arrest at metaphase I: homologous chromosomes pair in spermatocytes but show defective synapsis (PubMed:29742103). Belongs to the XPF family. Highly divergent. Although related to the XPF family, the nuclease active site is not conserved. resolution of meiotic recombination intermediates condensed nuclear chromosome DNA binding single-stranded DNA binding protein binding chromosome hydrolase activity ATPase activity meiotic cell cycle uc290myt.1 uc290myt.2 
ENSMUST00000107554.2 Zkscan16 ENSMUST00000107554.2 zinc finger with KRAB and SCAN domains 16, transcript variant 1 (from RefSeq NM_001355408.1) A2ALW2 A2ALW2_MOUSE ENSMUST00000107554.1 NM_001355408 Zkscan16 uc008szl.1 uc008szl.2 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc008szl.1 uc008szl.2 
ENSMUST00000107556.10 Tsacc ENSMUST00000107556.10 TSSK6 activating co-chaperone, transcript variant 2 (from RefSeq NM_001357024.1) ENSMUST00000107556.1 ENSMUST00000107556.2 ENSMUST00000107556.3 ENSMUST00000107556.4 ENSMUST00000107556.5 ENSMUST00000107556.6 ENSMUST00000107556.7 ENSMUST00000107556.8 ENSMUST00000107556.9 NM_001357024 Q9DA44 TSACC_MOUSE uc008puk.1 uc008puk.2 uc008puk.3 Co-chaperone that facilitates HSP-mediated activation of TSSK6. Interacts with HSP70. Associates with HSP90. Interacts with TSSK6; this interaction is direct and recruits TSACC to HSP90 (By similarity). In testis, expressed in the inner luminal layer of the seminiferous tubules. Belongs to the TSACC family. protein kinase inhibitor activity cytoplasm negative regulation of protein kinase activity protein kinase binding Hsp70 protein binding positive regulation of protein kinase activity chaperone binding uc008puk.1 uc008puk.2 uc008puk.3 
ENSMUST00000107558.9 Mef2d ENSMUST00000107558.9 myocyte enhancer factor 2D, transcript variant 11 (from RefSeq NM_001410084.1) E9QKT0 E9QKT0_MOUSE ENSMUST00000107558.1 ENSMUST00000107558.2 ENSMUST00000107558.3 ENSMUST00000107558.4 ENSMUST00000107558.5 ENSMUST00000107558.6 ENSMUST00000107558.7 ENSMUST00000107558.8 Mef2d NM_001410084 uc008pub.1 uc008pub.2 uc008pub.3 uc008pub.4 Nucleus RNA polymerase II regulatory region sequence-specific DNA binding DNA binding nucleus positive regulation of transcription from RNA polymerase II promoter protein dimerization activity uc008pub.1 uc008pub.2 uc008pub.3 uc008pub.4 
ENSMUST00000107574.8 Lpar1 ENSMUST00000107574.8 lysophosphatidic acid receptor 1, transcript variant 6 (from RefSeq NM_001421011.1) ENSMUST00000107574.1 ENSMUST00000107574.2 ENSMUST00000107574.3 ENSMUST00000107574.4 ENSMUST00000107574.5 ENSMUST00000107574.6 ENSMUST00000107574.7 Edg2 Lpar1 NM_001421011 Q544V2 Q544V2_MOUSE uc290mxw.1 uc290mxw.2 Cell surface Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein alpha-subunit binding G-protein coupled receptor activity phospholipid binding cytoplasm endosome plasma membrane signal transduction G-protein coupled receptor signaling pathway activation of phospholipase C activity brain development cell surface positive regulation of cell death negative regulation of neuron projection development oligodendrocyte development membrane integral component of membrane cerebellum development optic nerve development neurogenesis corpus callosum development endocytic vesicle lysophosphatidic acid binding myelination neuron projection neuronal cell body positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling dendritic spine dendritic shaft negative regulation of cAMP-mediated signaling positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway cell chemotaxis positive regulation of dendritic spine development lysophosphatidic acid receptor activity cellular response to oxygen levels positive regulation of smooth muscle cell chemotaxis cellular response to 1-oleoyl-sn-glycerol 3-phosphate uc290mxw.1 uc290mxw.2 
ENSMUST00000107576.2 Spmap1 ENSMUST00000107576.2 sperm microtubule associated protein 1 (from RefSeq NM_028156.2) ENSMUST00000107576.1 NM_028156 Q80ZQ1 Q9DAQ5 SPMA1_MOUSE uc007let.1 uc007let.2 Sequence=AAH48607.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc007let.1 uc007let.2 
ENSMUST00000107585.9 Cisd3 ENSMUST00000107585.9 CDGSH iron sulfur domain 3, transcript variant 1 (from RefSeq NM_001364153.1) B2RWE3 B2RWE3_MOUSE Cisd3 ENSMUST00000107585.1 ENSMUST00000107585.2 ENSMUST00000107585.3 ENSMUST00000107585.4 ENSMUST00000107585.5 ENSMUST00000107585.6 ENSMUST00000107585.7 ENSMUST00000107585.8 NM_001364153 uc288bvi.1 uc288bvi.2 Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; intracellular membrane-bounded organelle 2 iron, 2 sulfur cluster binding uc288bvi.1 uc288bvi.2 
ENSMUST00000107596.9 Srcin1 ENSMUST00000107596.9 SRC kinase signaling inhibitor 1 (from RefSeq NM_018873.2) B1AQX9 B1AQX9_MOUSE ENSMUST00000107596.1 ENSMUST00000107596.2 ENSMUST00000107596.3 ENSMUST00000107596.4 ENSMUST00000107596.5 ENSMUST00000107596.6 ENSMUST00000107596.7 ENSMUST00000107596.8 NM_018873 Srcin1 uc007lee.1 uc007lee.2 uc007lee.3 cytoplasm postsynaptic density actin cytoskeleton protein kinase binding protein domain specific binding lamellipodium filopodium regulation of cell migration axon dendrite substrate adhesion-dependent cell spreading neuron projection neuronal cell body synapse negative regulation of protein secretion regulation of dendritic spine morphogenesis positive regulation of protein tyrosine kinase activity negative regulation of protein tyrosine kinase activity uc007lee.1 uc007lee.2 uc007lee.3 
ENSMUST00000107619.3 Klf4 ENSMUST00000107619.3 Kruppel-like transcription factor 4 (gut) (from RefSeq NM_010637.3) ENSMUST00000107619.1 ENSMUST00000107619.2 Ezf Gklf KLF4_MOUSE NM_010637 P70421 Q3U2D6 Q3URS6 Q60793 Q78K30 Q9R255 Zie uc008sxk.1 uc008sxk.2 uc008sxk.3 uc008sxk.4 Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216). Binds to the promoter region of its own gene and can activate its own transcription (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216). Regulates the expression of key transcription factors during embryonic development (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216). Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216). Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity). Interacts with MUC1 (via the C-terminal domain) (By similarity). Interacts with POU5F1/OCT4 and SOX2 (PubMed:19816951). Interacts with MEIS2 isoform MeisD and PBX1 isoform PBX1a (By similarity). Interacts with ZNF296 (PubMed:24161396). Interacts with GLIS1 (By similarity). Interacts with BTRC; this interaction leads to KLF4 ubiquitination and subsequent degradation (PubMed:29593216). Interacts with IPO7; the interaction facilitates nuclear translocation of KLF4 in dental papilla cells (PubMed:35922041). Q60793; Q63844: Mapk3; NbExp=3; IntAct=EBI-3043905, EBI-397682; Q60793; Q9Y297: BTRC; Xeno; NbExp=3; IntAct=EBI-3043905, EBI-307461; Q60793; Q9UKB1: FBXW11; Xeno; NbExp=4; IntAct=EBI-3043905, EBI-355189; Q60793; P27361: MAPK3; Xeno; NbExp=2; IntAct=EBI-3043905, EBI-73995; Q60793; O95793: STAU1; Xeno; NbExp=7; IntAct=EBI-3043905, EBI-358174; Nucleus toplasm Highest expression in the colon. Lower levels in testis, lung and small intestine. By interferon-gamma in Stat1-dependent manner. the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Ubiquitinated. 'Lys-48'-linked ubiquitinated and targeted for proteasomal degradation by the SCF(BTRC) E3 ubiquitin-protein ligase complex, thereby negatively regulating cell pluripotency maintenance and embryogenesis. Polyglutamylated by TTLL1 and TTLL4 at Glu-381, which inhibits KLF4 binding with E3 ligase component BTRC, thereby impeding ubiquitination (PubMed:29593216). Deglutamylated by CCP1 and CCP6; deglutamylation promotes KLF4 ubiquitination (PubMed:29593216). KLF4 glutamylation state plays a critical role in the regulation of its function in cell reprogramming, pluripotency maintenance and embryogenesis (PubMed:29593216). Death shortly after birth due to loss of epidermal barrier function resulting from perturbation of late-stage epidermal differentiation structures including the cornified envelope. When selectively deleted in the surface ectoderm-derived structures of the eye, embryos develop normally and adults are viable and fertile but mutants display down-regulation of Krt12 and Aqp5 and multiple ocular defects including corneal epithelial fragility, stromal edema, defective lens and loss of conjunctival goblet cells. POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAC52939.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH10301.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter chromatin nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription factor recruiting RNA polymerase II transcription factor binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex nuclear euchromatin cytoplasm transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter beta-catenin binding transcription factor binding negative regulation of cell proliferation epidermal cell differentiation response to organic substance positive regulation of gene expression negative regulation of gene expression negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of muscle hyperplasia negative regulation of angiogenesis stem cell population maintenance cell differentiation negative regulation of cell migration post-embryonic camera-type eye development negative regulation of NF-kappaB transcription factor activity positive regulation of cellular protein metabolic process response to retinoic acid negative regulation of heterotypic cell-cell adhesion phosphatidylinositol 3-kinase regulator activity post-embryonic hemopoiesis regulation of cell proliferation histone deacetylase binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity regulation of phosphatidylinositol 3-kinase activity sequence-specific DNA binding transcription regulatory region DNA binding nuclear transcription factor complex negative regulation of interleukin-8 biosynthetic process positive regulation of nitric oxide biosynthetic process fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of hemoglobin biosynthetic process negative regulation of smooth muscle cell proliferation regulation of axon regeneration epidermis morphogenesis positive regulation of protein metabolic process negative regulation of protein kinase B signaling positive regulation of telomerase activity canonical Wnt signaling pathway negative regulation of response to cytokine stimulus pri-miRNA transcription from RNA polymerase II promoter cellular response to hydrogen peroxide negative regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to growth factor stimulus cellular response to organic cyclic compound cellular response to cycloheximide cellular response to laminar fluid shear stress negative regulation of cell migration involved in sprouting angiogenesis cellular response to peptide positive regulation of sprouting angiogenesis positive regulation of core promoter binding negative regulation of leukocyte adhesion to arterial endothelial cell cellular response to leukemia inhibitory factor promoter-specific chromatin binding negative regulation of G1/S transition of mitotic cell cycle negative regulation of chemokine (C-X-C motif) ligand 2 production uc008sxk.1 uc008sxk.2 uc008sxk.3 uc008sxk.4 
ENSMUST00000107624.8 Sp2 ENSMUST00000107624.8 Sp2 transcription factor, transcript variant 1 (from RefSeq NM_030220.4) ENSMUST00000107624.1 ENSMUST00000107624.2 ENSMUST00000107624.3 ENSMUST00000107624.4 ENSMUST00000107624.5 ENSMUST00000107624.6 ENSMUST00000107624.7 NM_030220 Q8C5J0 Q8C5J0_MOUSE Sp2 uc007ldf.1 uc007ldf.2 uc007ldf.3 uc007ldf.4 This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. The protein can act as a transcriptional activator or repressor, depending on the promoter and cell type. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK156580.1, AK078246.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## Nucleus negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding nucleus multicellular organism growth histone deacetylase binding uc007ldf.1 uc007ldf.2 uc007ldf.3 uc007ldf.4 
ENSMUST00000107635.7 Lrba ENSMUST00000107635.7 LPS-responsive beige-like anchor, transcript variant 1 (from RefSeq NM_030695.2) E9Q3Y4 E9Q3Y4_MOUSE ENSMUST00000107635.1 ENSMUST00000107635.2 ENSMUST00000107635.3 ENSMUST00000107635.4 ENSMUST00000107635.5 ENSMUST00000107635.6 Lrba NM_030695 uc008pri.1 uc008pri.2 uc008pri.3 uc008pri.1 uc008pri.2 uc008pri.3 
ENSMUST00000107636.4 Prr15l ENSMUST00000107636.4 proline rich 15-like (from RefSeq NM_146026.2) Atad4 ENSMUST00000107636.1 ENSMUST00000107636.2 ENSMUST00000107636.3 NM_146026 PR15L_MOUSE Q8C307 Q8JZM2 uc007lcy.1 uc007lcy.2 uc007lcy.3 uc007lcy.4 Belongs to the PRR15 family. Sequence=BAC39930.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; molecular_function cellular_component biological_process uc007lcy.1 uc007lcy.2 uc007lcy.3 uc007lcy.4 
ENSMUST00000107651.9 Slc44a1 ENSMUST00000107651.9 solute carrier family 44, member 1, transcript variant 3 (from RefSeq NM_001374697.1) A2AMH5 A2AMH5_MOUSE ENSMUST00000107651.1 ENSMUST00000107651.2 ENSMUST00000107651.3 ENSMUST00000107651.4 ENSMUST00000107651.5 ENSMUST00000107651.6 ENSMUST00000107651.7 ENSMUST00000107651.8 NM_001374697 Slc44a1 uc008sxb.1 uc008sxb.2 uc008sxb.3 Choline transporter. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the CTL (choline transporter-like) family. membrane integral component of membrane uc008sxb.1 uc008sxb.2 uc008sxb.3 
ENSMUST00000107670.3 Or13c3 ENSMUST00000107670.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG87) ENSMUST00000107670.1 ENSMUST00000107670.2 Olfr273 Or13c3 Q8VG87 Q8VG87_MOUSE uc008swp.1 uc008swp.2 uc008swp.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008swp.1 uc008swp.2 uc008swp.3 
ENSMUST00000107675.8 Fbxw7 ENSMUST00000107675.8 Fbxw7 (from geneSymbol) D3YUA8 D3YUA8_MOUSE ENSMUST00000107675.1 ENSMUST00000107675.2 ENSMUST00000107675.3 ENSMUST00000107675.4 ENSMUST00000107675.5 ENSMUST00000107675.6 ENSMUST00000107675.7 Fbxw7 NM_001428748 uc290ggq.1 uc290ggq.2 uc290ggq.1 uc290ggq.2 
ENSMUST00000107682.2 Tmem154 ENSMUST00000107682.2 transmembrane protein 154 (from RefSeq NM_177260.2) ENSMUST00000107682.1 NM_177260 Q3TB17 Q3TCN6 Q3TD45 Q8C4Q9 Q8CB06 TM154_MOUSE uc008pqj.1 uc008pqj.2 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C4Q9-1; Sequence=Displayed; Name=2; IsoId=Q8C4Q9-2; Sequence=VSP_024546, VSP_024547; molecular_function cellular_component biological_process membrane integral component of membrane uc008pqj.1 uc008pqj.2 
ENSMUST00000107689.7 Fhdc1 ENSMUST00000107689.7 FH2 domain containing 1, transcript variant 2 (from RefSeq NM_001033301.4) B9EHC4 ENSMUST00000107689.1 ENSMUST00000107689.2 ENSMUST00000107689.3 ENSMUST00000107689.4 ENSMUST00000107689.5 ENSMUST00000107689.6 FHDC1_MOUSE Inf1 Kiaa1727 NM_001033301 Q3ULZ2 Q69ZC2 Q8C0A0 uc008pqd.1 uc008pqd.2 uc008pqd.3 uc008pqd.4 uc008pqd.5 Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). Interacts with CEP170. Golgi apparatus Cell projection, cilium Note=Associates with microtubules. Brain, heart and lung (at protein level). The FH2 and MBD domains are essential for its function in regulating Golgi ribbon formation. Sequence=BAD32522.1; Type=Erroneous initiation; Evidence=; actin binding protein binding Golgi apparatus microtubule cytoplasmic microtubule cilium microtubule binding cell projection organization cell projection stress fiber assembly cilium assembly Golgi ribbon formation uc008pqd.1 uc008pqd.2 uc008pqd.3 uc008pqd.4 uc008pqd.5 
ENSMUST00000107692.8 Trim2 ENSMUST00000107692.8 tripartite motif-containing 2, transcript variant 2 (from RefSeq NM_001271726.1) ENSMUST00000107692.1 ENSMUST00000107692.2 ENSMUST00000107692.3 ENSMUST00000107692.4 ENSMUST00000107692.5 ENSMUST00000107692.6 ENSMUST00000107692.7 Kiaa0517 NM_001271726 Narf Q3UHP5 Q5DU27 Q8C981 Q9ESN6 TRIM2_MOUSE uc008ppz.1 uc008ppz.2 uc008ppz.3 uc008ppz.4 uc008ppz.5 UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits new world arenavirus infection independently of its ubiquitin ligase activity by decreasing virus internalization (PubMed:30726215). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Forms homooligomers (By similarity). Interacts with TRIM3; this interaction reduces TRIM2 activity (By similarity). Interacts with myosin V; myosin V may not be a substrate for ubiquitination. Interacts with NEFL. Interacts with phosphorylated BCL2L11. Interacts with SIRPA (PubMed:30726215). Q9ESN6; P08551: Nefl; NbExp=2; IntAct=EBI-8315064, EBI-445199; Cytoplasm Highly expressed in the cerebellum, hippocampus, retina and spinal cord. In the cerebellum, strongest expression in Purkinje cells and in the deep cerebellar nuclei. In retina, high expression in the ganglionic cell layer, inner nuclear layer and inthe outer plexiform layer. Particularly high expression in the hippocampus, in pyramidal cells of CA1-CA3 hippocampal areas and ingranule cells of the dentate gyrus. At 12.5 dpc, expressed in the developing nervous system, particularly in the spinal cord, dorsal rootganglia, hindbrain and midbrain. The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades. RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination. Mutant mice are indistinguishable from wild type until about 1.5 months of age, when they begin to show intention tremor, followed by gait ataxia. At this stage, neurons exhibit axonal swellings, which consist of the accumulation of disorganized neurofilaments and microtubules, mitochondria and vesicles. In later stages, mutant animals suffer from episodes of spontaneous generalized seizures, a phenotype caused by progressive loss of Purkinje cells through apoptosis. At 4 months of age, retinas in mutant mice display decreased thickness of the inner nuclear layer and a reduced number of ganglionic cells. The outer plexiform layer is also reduced, whereas the size of the photoreceptor layer is not altered (PubMed:18687884). In addition, TRIM2-knockout mice are also more susceptible to infection with new world arenaviruses (PubMed:30726215). Belongs to the TRIM/RBCC family. Sequence=BAD90242.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein polyubiquitination ubiquitin-protein transferase activity protein binding cytoplasm zinc ion binding protein ubiquitination transferase activity myosin binding proteasome-mediated ubiquitin-dependent protein catabolic process regulation of neuron apoptotic process metal ion binding ubiquitin protein ligase activity cellular response to leukemia inhibitory factor uc008ppz.1 uc008ppz.2 uc008ppz.3 uc008ppz.4 uc008ppz.5 
ENSMUST00000107712.8 Gngt2 ENSMUST00000107712.8 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (from UniProt Q61017) BC061005 ENSMUST00000107712.1 ENSMUST00000107712.2 ENSMUST00000107712.3 ENSMUST00000107712.4 ENSMUST00000107712.5 ENSMUST00000107712.6 ENSMUST00000107712.7 GBGT2_MOUSE Gng8 Gngt8 Q61017 Q9CWL5 uc288bpr.1 uc288bpr.2 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units, alpha, beta and gamma. Cell membrane ; Lipid-anchor ; Cytoplasmic side Belongs to the G protein gamma family. GTPase activity heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane G-protein beta/gamma-subunit complex G-protein beta-subunit binding uc288bpr.1 uc288bpr.2 
ENSMUST00000107717.8 Zfp652 ENSMUST00000107717.8 Functions as a transcriptional repressor. (from UniProt Q5DU09) A2A617 AK220361 ENSMUST00000107717.1 ENSMUST00000107717.2 ENSMUST00000107717.3 ENSMUST00000107717.4 ENSMUST00000107717.5 ENSMUST00000107717.6 ENSMUST00000107717.7 Kiaa0924 Q5DU09 Q7TNT4 ZN652_MOUSE Znf652 uc007laq.1 uc007laq.2 uc007laq.3 uc007laq.4 Functions as a transcriptional repressor. Interacts with CBFA2T3. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5DU09-1; Sequence=Displayed; Name=2; IsoId=Q5DU09-2; Sequence=VSP_023669, VSP_023670; Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus biological_process metal ion binding uc007laq.1 uc007laq.2 uc007laq.3 uc007laq.4 
ENSMUST00000107720.9 Stx17 ENSMUST00000107720.9 syntaxin 17 (from RefSeq NM_026343.2) B1AVI3 ENSMUST00000107720.1 ENSMUST00000107720.2 ENSMUST00000107720.3 ENSMUST00000107720.4 ENSMUST00000107720.5 ENSMUST00000107720.6 ENSMUST00000107720.7 ENSMUST00000107720.8 NM_026343 Q9D0I4 Q9D330 STX17_MOUSE Stx17 uc008sux.1 uc008sux.2 uc008sux.3 uc008sux.4 SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity). Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome (By similarity). May interact with VTI1B (By similarity). Probably interacts with BET1, SCFD1 and SEC22B (By similarity). Interacts with PTPN2 and ABL1; involved in STX17 phosphorylation (By similarity). Interacts with COPB1 (By similarity). Interacts with TMED9 and TMED10; the interaction is direct (By similarity). Interacts with VAMP7 (PubMed:23217709). Interacts with RUBCNL/PACER; promoting targeting of RUBCNL/PACER to autophagosome (By similarity). Interacts with VAMP8, SNAP29, VPS39 and VPS41; these interactions are increased in the absence of TMEM39A (By similarity). Interacts with IRGM; promoting STX17 recruitment to autophagosomes (By similarity). Interacts with ATG8 proteins GABARAP and MAP1LC3B (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Smooth endoplasmic reticulum membrane ; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein Cytoplasmic vesicle, COPII-coated vesicle membrane ; Multi-pass membrane protein Cytoplasm, cytosol Mitochondrion membrane ; Multi-pass membrane protein Note=Has a hairpin-like insertion into membranes. Localizes to the completed autophagosome membrane upon cell starvation (By similarity). Dephosphorylation by PTPN2; regulates exit from the endoplasmic reticulum (By similarity). Phosphorylated at Tyr-156 probably by ABL1 (PubMed:23006999). Belongs to the syntaxin family. SNARE binding autophagosome membrane SNAP receptor activity cytoplasm mitochondrion autophagosome endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment cytosol intracellular protein transport ER to Golgi vesicle-mediated transport vesicle fusion autophagy Golgi organization endomembrane system ER to Golgi transport vesicle membrane membrane integral component of membrane vesicle-mediated transport autophagosome docking protein kinase binding protein phosphatase binding ER to Golgi transport vesicle smooth endoplasmic reticulum membrane HOPS complex SNARE complex cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment membrane protein localization to pre-autophagosomal structure ER-mitochondrion membrane contact site vesicle docking endoplasmic reticulum-Golgi intermediate compartment organization autophagosome maturation uc008sux.1 uc008sux.2 uc008sux.3 uc008sux.4 
ENSMUST00000107724.9 Spop ENSMUST00000107724.9 speckle-type BTB/POZ protein, transcript variant 1 (from RefSeq NM_025287.2) ENSMUST00000107724.1 ENSMUST00000107724.2 ENSMUST00000107724.3 ENSMUST00000107724.4 ENSMUST00000107724.5 ENSMUST00000107724.6 ENSMUST00000107724.7 ENSMUST00000107724.8 NM_025287 Pcif1 Q3TLC2 Q5ST07 Q6ZWS8 Q76LV9 SPOP_MOUSE Spop uc007laj.1 uc007laj.2 uc007laj.3 Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL (By similarity). In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (By similarity). Protein modification; protein ubiquitination. Homodimer and homooligomer. Heterodimer with SPOPL. Each dimer interacts with two CUL3 molecules. Part of cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain CUL3 and homodimeric SPOP, or the heterodimer formed by SPOP and SPOPL, plus a target protein, such as MACROH2A1, PDX1/IPF1, BMI1, BRMS1 and DAXX (By similarity). Interacts with MACROH2A1, PDX1/IPF1, GLI2 and GLI3. Q6ZWS8; Q0VGT2: Gli2; NbExp=2; IntAct=EBI-7128920, EBI-9344284; Q6ZWS8; P52946: Pdx1; NbExp=5; IntAct=EBI-7128920, EBI-7128945; Q6ZWS8; P10071: GLI3; Xeno; NbExp=2; IntAct=EBI-7128920, EBI-308055; Nucleus Nucleus speckle Widely expressed, mainly in pancreas and in particular in adult pancreatic insulin-producing beta cells and in a subset of exocrine acinar and duct cells. The BTB (POZ) domain mediates dimerization and interaction with CUL3. The MATH domain mediates interaction with protein-ubiquitin ligase substrates, such as MACROH2A1 and BMI1. Belongs to the Tdpoz family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding protein binding nucleus cytoplasm ubiquitin-dependent protein catabolic process protein ubiquitination nuclear speck regulation of proteolysis Cul3-RING ubiquitin ligase complex ubiquitin protein ligase binding glucose homeostasis proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of type B pancreatic cell apoptotic process uc007laj.1 uc007laj.2 uc007laj.3 
ENSMUST00000107729.10 Cyth2 ENSMUST00000107729.10 cytohesin 2, transcript variant 1 (from RefSeq NM_011181.4) Cyth2 ENSMUST00000107729.1 ENSMUST00000107729.2 ENSMUST00000107729.3 ENSMUST00000107729.4 ENSMUST00000107729.5 ENSMUST00000107729.6 ENSMUST00000107729.7 ENSMUST00000107729.8 ENSMUST00000107729.9 NM_011181 Pscd2 Q99KH2 Q99KH2_MOUSE uc009gxf.1 uc009gxf.2 uc009gxf.3 uc009gxf.4 Cytoplasm Membrane ; Peripheral membrane protein ARF guanyl-nucleotide exchange factor activity cytoplasm plasma membrane regulation of ARF protein signal transduction uc009gxf.1 uc009gxf.2 uc009gxf.3 uc009gxf.4 
ENSMUST00000107734.10 Kat7 ENSMUST00000107734.10 K(lysine) acetyltransferase 7, transcript variant 19 (from RefSeq NM_001405209.1) ENSMUST00000107734.1 ENSMUST00000107734.2 ENSMUST00000107734.3 ENSMUST00000107734.4 ENSMUST00000107734.5 ENSMUST00000107734.6 ENSMUST00000107734.7 ENSMUST00000107734.8 ENSMUST00000107734.9 Hbo1 KAT7_MOUSE Kat7 Myst2 NM_001405209 Q5SVQ0 Q5SVQ1 Q5SVQ2 Q5SVQ3 Q5SVQ7 Q6PGC6 Q80Y65 uc007lae.1 uc007lae.2 uc007lae.3 uc007lae.4 Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:21753189, PubMed:21149574, PubMed:23319590, PubMed:27733580, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (By similarity). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (By similarity). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (By similarity). H3K14ac is also required for T-cell development (PubMed:27733580). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (By similarity). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (By similarity). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (By similarity). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (By similarity). Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45949; Evidence=; Histone acetyltransferase activity is inhibited by GMNN in the context of a complex with CDT1, inhibiting histone H4 acetylation and DNA replication licensing. Component of the HBO1 complex composed of KAT7/HBO1, MEAF6, ING4 or ING5, and one scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE scaffold (JADE1, JADE2 and JADE3) mediate acetylation of histone H4 (PubMed:21753189, PubMed:31827282). Interacts with MCM2 and ORC1 (By similarity). Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone (By similarity). Interacts with CDT1 (By similarity). Interacts with MAP2K1 and CUL1 (PubMed:23319590). Interacts with p53/TP53; leading to inhibit histone acetyltransferase activity (By similarity). Nucleus romosome Chromosome, centromere Cytoplasm, cytosol Note=Associates with replication origins specifically during the G1 phase of the cell cycle. Localizes to transcription start sites. Localizes to ultraviolet-induced DNA damage sites following phosphorylation by ATR. Localizes to centromeres in G1 phase. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q5SVQ0-1; Sequence=Displayed; Name=2; IsoId=Q5SVQ0-2; Sequence=VSP_014584; Name=3; IsoId=Q5SVQ0-3; Sequence=VSP_014582; Name=4; IsoId=Q5SVQ0-4; Sequence=VSP_014582, VSP_014584; Name=5; IsoId=Q5SVQ0-5; Sequence=VSP_014582, VSP_014583, VSP_014584; Widely expressed in adult tissues. Expressed ubiquitously in the embryonic and extraembryonic tissues (PubMed:21149574). High levels are present in the chorionic plate (8.5 dpc and 9.5 dpc) as well as in and around the foregut and hindgut regions (9.5 dpc) (PubMed:21149574). The C2HC MYST-type zinc finger is required for interaction with MCM2 and ORC1. The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction. Phosphorylated at Ser-52 and Ser-55 by ATR in response to DNA damage, promoting its ubiquitination by the CRL4(DDB2) complex and subsequent degradation. Phosphorylation at Ser-52 and Ser-55 by ATR in response to ultraviolet-induced DNA, promotes localization to DNA damage sites. Phosphorylation at Ser-59 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-87 and Thr-90 by CDK1 (By similarity). Phosphorylated by MAP2K1, which accelerates its degradation (PubMed:23319590). Ubiquitinated at Lys-340, leading to proteasomal degradation. Ubiquitinated by the CRL4(DDB2) complex following phosphorylation by ATR, leading to its subsequent degradation. Autoacetylation at Lys-434 is required for proper function. Embryonic lethality caused by a strong reduction of histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:21149574). Development is arrested at the 10-somite stage (PubMed:21149574). Blood vessels, mesenchyme, and somites are disorganized (PubMed:21149574). No defects in DNA replication or cell proliferation are observed (PubMed:21149574). Conditional mice lacking Kat7 in thymocytes display normal alpha-beta T-cells but show impaired development of peripheral CD4(+) or CD8(+) T-cells (PubMed:27733580). Belongs to the MYST (SAS/MOZ) family. histone acetyltransferase complex nuclear chromatin DNA replication origin binding transcription factor activity, sequence-specific DNA binding histone acetyltransferase activity nucleus nucleoplasm cytoplasm cytosol DNA replication chromatin organization regulation of transcription, DNA-templated zinc ion binding histone acetylation transferase activity transferase activity, transferring acyl groups internal peptidyl-lysine acetylation stress-activated protein kinase signaling cascade histone binding histone H3 acetylation histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K12 acetylation transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding response to sorbitol response to hydroxyurea response to actinomycin D response to dithiothreitol response to anisomycin positive regulation of histone H4 acetylation positive regulation of protein localization to nucleus nucleolus histone H4-K16 acetylation uc007lae.1 uc007lae.2 uc007lae.3 uc007lae.4 
ENSMUST00000107736.2 Asic5 ENSMUST00000107736.2 Membrane ; Multi- pass membrane protein (from UniProt D3Z0S5) AK038321 Accn5 Asic5 D3Z0S5 D3Z0S5_MOUSE ENSMUST00000107736.1 uc290gds.1 uc290gds.2 Membrane ; Multi- pass membrane protein Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. sodium channel activity ion transport sodium ion transport membrane integral component of membrane sodium ion transmembrane transport uc290gds.1 uc290gds.2 
ENSMUST00000107737.11 Sphk2 ENSMUST00000107737.11 sphingosine kinase 2, transcript variant 1 (from RefSeq NM_203280.3) ENSMUST00000107737.1 ENSMUST00000107737.10 ENSMUST00000107737.2 ENSMUST00000107737.3 ENSMUST00000107737.4 ENSMUST00000107737.5 ENSMUST00000107737.6 ENSMUST00000107737.7 ENSMUST00000107737.8 ENSMUST00000107737.9 NM_203280 Q91VA9 Q9DBH6 Q9JIA7 SPHK2_MOUSE Sphk2 uc009gwu.1 uc009gwu.2 uc009gwu.3 uc009gwu.4 This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]. Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions (PubMed:16118219, PubMed:17346996, PubMed:21084291). Also acts on D-erythro-dihydrosphingosine, D-erythro- sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:16118219, PubMed:10751414). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12. In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (By similarity). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (PubMed:17346996). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (PubMed:25637806). Also involved in the regulation of glucose and lipid metabolism (PubMed:30593892). Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+); Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216; EC=2.7.1.91; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51497; Evidence=; Reaction=ATP + sphing-4-enine = ADP + H(+) + sphing-4-enine 1- phosphate; Xref=Rhea:RHEA:35847, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119, ChEBI:CHEBI:456216; EC=2.7.1.91; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35848; Evidence=; Reaction=ATP + sphinganine = ADP + H(+) + sphinganine 1-phosphate; Xref=Rhea:RHEA:15465, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57817, ChEBI:CHEBI:57939, ChEBI:CHEBI:456216; EC=2.7.1.91; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15466; Evidence=; Reaction=(4R)-hydroxysphinganine + ATP = (4R)-hydroxysphinganine 1- phosphate + ADP + H(+); Xref=Rhea:RHEA:33563, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:64124, ChEBI:CHEBI:64795, ChEBI:CHEBI:456216; EC=2.7.1.91; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33564; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Kinetic parameters: KM=3.4 uM for sphing-4-enine ; Vmax=0.1 nmol/min/mg enzyme ; Vmax=0.3 nmol/min/mg enzyme (in the presence of 50 mM KCl); Vmax=1 nmol/min/mg enzyme (in the presence of 200 mM KCl); pH dependence: Optimum pH is 7.5. ; Interacts with histone H3. Interacts with HDAC1, HDAC2, MBD2 and SIN3A. Interacts with EEF1A1; the interaction enhances SPHK2 kinase activity (By similarity). Interacts with PHB2 (PubMed:20959514). Q9JIA7; P39688: Fyn; NbExp=2; IntAct=EBI-985434, EBI-524514; Lysosome membrane Cytoplasm Cell membrane Endoplasmic reticulum Nucleus tochondrion inner membrane Note=In nucleus, is located in nucleosomes where it associates with core histone proteins such as histone 3. In apoptotic cells, colocalizes with CASP1 in cell membrane where is cleaved and released from cells in an active form. Expressed in heart, brain, liver, kidney and testis (PubMed:10751414). Expressed by mast cells (at protein level) (PubMed:17346996). In the substantia nigra, expressed by dopaminergic neurons (at protein level) (PubMed:25637806). At 10.5 dpc, expression is relatively ubiquitous with the strongest signals detected in the limb buds, eyes and branchial arches and a weaker expression in the telencephalon and spinal cord. Expressopm decreases upon treatment with 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) which is used to induce Parkinson disease in mouse model. Phosphorylated by PKD on Ser-384 and Ser-386 upon PMA treatment. Phosphorylation induces export from the nucleus to the cytoplasm. Phosphorylated by MAPK1 and MAPK2 at Thr-578, phosphorylation is induced by agonists such as EGF and PMA and increases kinase activity. Cleaved by CASP1 in apoptotic cells. The truncated form is released from cells. Mutant mice are viable, fertile and have normal longevity. They show reduced SPP levels (PubMed:16314531). Mice have decreased fat mass but increased lean mass, they display increased energy expenditure compared to wild-type. Aging mice are protected from metabolic decline and obesity. 52-week old male mutant mice have decreased weight and fat mass, and increased glucose tolerance and insulin sensitivity compared to control mice (PubMed:30593892). Double knockout for SPHK1 and SPHK2 causes embryonic lethality (PubMed:16314531). Between 11.5 dpc and 12.5 dpc embryos exhibit cranial hemorrhage and die at 13.5 dpc (PubMed:16314531). At 11.5 dpc the wall of the dorsal aorta is poorly developed and endothelial cells are severely defective in all blood vessels in the mesenchymal region of the head (PubMed:16314531). Embryos also show a neural tube defect (PubMed:16314531). nucleotide binding nucleosome blood vessel development cytokine secretion involved in immune response sphingosine-1-phosphate signaling pathway NAD+ kinase activity protein binding ATP binding nucleus cytoplasm mitochondrion mitochondrial inner membrane lysosome lysosomal membrane endoplasmic reticulum cytosol plasma membrane sphinganine-1-phosphate biosynthetic process sphingosine metabolic process brain development female pregnancy cell proliferation positive regulation of cell proliferation sphinganine kinase activity membrane kinase activity phosphorylation transferase activity D-erythro-sphingosine kinase activity negative regulation of cell growth negative regulation of histone deacetylation nucleosomal histone binding positive regulation of mast cell activation involved in immune response sphingosine-1-phosphate receptor activity positive regulation of apoptotic process negative regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling intracellular membrane-bounded organelle positive regulation of mast cell degranulation histone H2A-K5 acetylation histone H2B-K12 acetylation positive regulation of gene expression, epigenetic sphingosine biosynthetic process lipid phosphorylation interleukin-6 secretion interleukin-13 secretion positive regulation of protein kinase C signaling positive regulation of calcium ion import negative regulation of histone deacetylase activity regulation of reactive oxygen species biosynthetic process cellular response to phorbol 13-acetate 12-myristate regulation of cytochrome-c oxidase activity tumor necrosis factor secretion positive regulation of ceramide biosynthetic process positive regulation of histone H3-K9 acetylation regulation of ATP biosynthetic process uc009gwu.1 uc009gwu.2 uc009gwu.3 uc009gwu.4 
ENSMUST00000107749.4 Gabbr2 ENSMUST00000107749.4 gamma-aminobutyric acid type B receptor subunit 2 (from RefSeq NM_001081141.2) A2AL05 ENSMUST00000107749.1 ENSMUST00000107749.2 ENSMUST00000107749.3 GABR2_MOUSE Gm425 Gpr51 NM_001081141 Q80T41 uc008sug.1 uc008sug.2 uc008sug.3 Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:10075644). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium- channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity). Heterodimer of GABBR1 and GABBR2 (PubMed:10075644). Homodimers may form, but are inactive (By similarity). Interacts (via C-terminus) with ATF4 (via leucine zipper domain) (By similarity). Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi- pass membrane protein Note=Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane (By similarity). Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABBR1. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. G-protein coupled receptor activity G-protein coupled GABA receptor activity protein binding cytoplasm plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway gamma-aminobutyric acid signaling pathway membrane integral component of membrane cell junction G-protein coupled receptor heterodimeric complex neuron projection synapse postsynaptic membrane protein heterodimerization activity glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane GABA receptor complex uc008sug.1 uc008sug.2 uc008sug.3 
ENSMUST00000107752.12 Hsd17b14 ENSMUST00000107752.12 hydroxysteroid (17-beta) dehydrogenase 14 (from RefSeq NM_025330.3) E9Q3D4 E9Q3D4_MOUSE ENSMUST00000107752.1 ENSMUST00000107752.10 ENSMUST00000107752.11 ENSMUST00000107752.2 ENSMUST00000107752.3 ENSMUST00000107752.4 ENSMUST00000107752.5 ENSMUST00000107752.6 ENSMUST00000107752.7 ENSMUST00000107752.8 ENSMUST00000107752.9 Hsd17b14 NM_025330 uc012fkm.1 uc012fkm.2 uc012fkm.3 Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24613; Evidence=; estradiol 17-beta-dehydrogenase activity cytosol steroid catabolic process oxidoreductase activity identical protein binding testosterone 17-beta-dehydrogenase (NADP+) activity oxidation-reduction process uc012fkm.1 uc012fkm.2 uc012fkm.3 
ENSMUST00000107756.4 Coro2a ENSMUST00000107756.4 coronin, actin binding protein 2A, transcript variant 2 (from RefSeq NM_001164804.1) COR2A_MOUSE ENSMUST00000107756.1 ENSMUST00000107756.2 ENSMUST00000107756.3 NM_001164804 Q3U6H8 Q8BW42 Q8C0P5 uc008sua.1 uc008sua.2 uc008sua.3 uc008sua.4 Binds actin. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Belongs to the WD repeat coronin family. actin binding brush border transcriptional repressor complex actin filament binding uc008sua.1 uc008sua.2 uc008sua.3 uc008sua.4 
ENSMUST00000107772.8 Tstd2 ENSMUST00000107772.8 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2, transcript variant 1 (from RefSeq NM_173033.3) B1AWH0 ENSMUST00000107772.1 ENSMUST00000107772.2 ENSMUST00000107772.3 ENSMUST00000107772.4 ENSMUST00000107772.5 ENSMUST00000107772.6 ENSMUST00000107772.7 NM_173033 Q3U269 Q6PES9 Q8C1D7 TSTD2_MOUSE uc008stg.1 uc008stg.2 uc008stg.3 molecular_function cellular_component biological_process uc008stg.1 uc008stg.2 uc008stg.3 
ENSMUST00000107773.3 Tmod1 ENSMUST00000107773.3 tropomodulin 1, transcript variant 1 (from RefSeq NM_021883.3) ENSMUST00000107773.1 ENSMUST00000107773.2 NM_021883 P49813 Q3KP84 Q9ERR9 TMOD1_MOUSE Tmod uc008ste.1 uc008ste.2 uc008ste.3 Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). Binds to the N-terminus of tropomyosin and to actin. Cytoplasm, cytoskeleton Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments. Highly expressed in the erythrocyte, heart and skeletal muscle. Belongs to the tropomodulin family. actin binding tropomyosin binding nucleus cytoplasm cytoskeleton striated muscle thin filament actin filament muscle contraction COP9 signalosome adult locomotory behavior membrane myofibril sarcomere myofibril assembly cortical cytoskeleton actin filament binding pointed-end actin filament capping lens fiber cell development uc008ste.1 uc008ste.2 uc008ste.3 
ENSMUST00000107774.3 Kcna7 ENSMUST00000107774.3 potassium voltage-gated channel, shaker-related subfamily, member 7 (from RefSeq NM_010596.2) ENSMUST00000107774.1 ENSMUST00000107774.2 KCNA7_MOUSE Kcnc7 NM_010596 O70259 Q17ST2 uc009guz.1 uc009guz.2 uc009guz.3 Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channels formed by isoform 1 inactivate faster than channels formed by isoform 2. Heterotetramer of potassium channel proteins. Membrane ulti-pass membrane protein Event=Alternative splicing, Alternative initiation; Named isoforms=2; Name=1; Synonyms=Kv1.7L; IsoId=Q17ST2-1; Sequence=Displayed; Name=2; Synonyms=Kv1.7S; IsoId=Q17ST2-2; Sequence=VSP_028953; Detected in heart, skeletal muscle, brain, and pancreatic islet cells. The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. [Isoform 2]: Produced by alternative initiation at Met- 33 of isoform 1. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily. Sequence=AAC12271.1; Type=Frameshift; Evidence=; Sequence=AAC23664.1; Type=Frameshift; Evidence=; ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane regulation of ion transmembrane transport protein homooligomerization transmembrane transport potassium ion transmembrane transport uc009guz.1 uc009guz.2 uc009guz.3 
ENSMUST00000107775.8 Zbbx ENSMUST00000107775.8 Zbbx (from geneSymbol) AK133102 D3Z0P7 D3Z0P7_MOUSE ENSMUST00000107775.1 ENSMUST00000107775.2 ENSMUST00000107775.3 ENSMUST00000107775.4 ENSMUST00000107775.5 ENSMUST00000107775.6 ENSMUST00000107775.7 Zbbx uc290fyr.1 uc290fyr.2 zinc ion binding uc290fyr.1 uc290fyr.2 
ENSMUST00000107783.8 Stra6l ENSMUST00000107783.8 Acts as a high-affinity cell-surface receptor for retinol- binding protein RBP4 and mediates RBP4-dependent retinol uptake in the liver. (from UniProt Q9DBN1) AK050152 B1AWX8 ENSMUST00000107783.1 ENSMUST00000107783.2 ENSMUST00000107783.3 ENSMUST00000107783.4 ENSMUST00000107783.5 ENSMUST00000107783.6 ENSMUST00000107783.7 Q14DP6 Q14DS9 Q8C7I6 Q9DBN1 Rbpr2 STR6L_MOUSE Stra6l uc290mmx.1 uc290mmx.2 Acts as a high-affinity cell-surface receptor for retinol- binding protein RBP4 and mediates RBP4-dependent retinol uptake in the liver. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DBN1-1; Sequence=Displayed; Name=2; IsoId=Q9DBN1-2; Sequence=VSP_058654; Highly expressed in liver and small intestine. Also expressed in spleen, kidney, colon, stomach, placenta, adipose tissue and isolated adipocytes. Induced in adipose tissue after high fat diet. Down- regulated by holo-RBP4, retinol and retinoic acid. Glycosylated. protein binding plasma membrane membrane integral component of membrane retinol transport vitamin A import uc290mmx.1 uc290mmx.2 
ENSMUST00000107802.8 Trim59 ENSMUST00000107802.8 tripartite motif-containing 59 (from RefSeq NM_025863.3) E9QKA7 ENSMUST00000107802.1 ENSMUST00000107802.2 ENSMUST00000107802.3 ENSMUST00000107802.4 ENSMUST00000107802.5 ENSMUST00000107802.6 ENSMUST00000107802.7 Mrf1 NM_025863 Q922Y2 Q9CSP2 Q9CUD5 Q9D740 TRI59_MOUSE uc008pmd.1 uc008pmd.2 uc008pmd.3 uc008pmd.4 E3 ubiquitin ligase involved in different processes such as development and immune response (PubMed:22588174, PubMed:29467473). Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT (PubMed:22588174). Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1. On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation. Acts also as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination (PubMed:29467473). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with ECSIT (PubMed:22588174). Endoplasmic reticulum membrane ; Single-pass membrane protein Moderately expressed in the spleen, brain and heart and very highly expressed in the testis (PubMed:12095697). TRIM59-deficiency causes early embryonic lethality. Affects the expression of gastrulation-associated genes during early embryonic development. Belongs to the TRIM/RBCC family. protein binding endoplasmic reticulum endoplasmic reticulum membrane zinc ion binding membrane integral component of membrane protein ubiquitination negative regulation of I-kappaB kinase/NF-kappaB signaling innate immune response negative regulation of viral entry into host cell metal ion binding ubiquitin protein ligase activity intraciliary transport particle B uc008pmd.1 uc008pmd.2 uc008pmd.3 uc008pmd.4 
ENSMUST00000107810.3 Tomm5 ENSMUST00000107810.3 translocase of outer mitochondrial membrane 5, transcript variant 1 (from RefSeq NM_001099675.1) B1AXP6 B1AXP7 B1AXP8 B1AXP9 ENSMUST00000107810.1 ENSMUST00000107810.2 NM_001099675 TOM5_MOUSE Tom5 Tomm5 uc008ssh.1 uc008ssh.2 uc008ssh.3 uc008ssh.4 Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Mitochondrion outer membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=B1AXP6-1; Sequence=Displayed; Name=2; IsoId=B1AXP6-2; Sequence=VSP_052943; Name=3; IsoId=B1AXP6-3; Sequence=VSP_052944; Name=4; IsoId=B1AXP6-4; Sequence=VSP_052945; Belongs to the Tom5 family. mitochondrion mitochondrial outer membrane mitochondrial outer membrane translocase complex protein targeting to mitochondrion protein transport membrane integral component of membrane uc008ssh.1 uc008ssh.2 uc008ssh.3 uc008ssh.4 
ENSMUST00000107812.8 Ift80 ENSMUST00000107812.8 intraflagellar transport 80 (from RefSeq NM_026641.2) ENSMUST00000107812.1 ENSMUST00000107812.2 ENSMUST00000107812.3 ENSMUST00000107812.4 ENSMUST00000107812.5 ENSMUST00000107812.6 ENSMUST00000107812.7 IFT80_MOUSE Kiaa1374 NM_026641 Q6ZPT0 Q8C9F1 Q8K057 Q91YV4 Wdr56 uc033hub.1 uc033hub.2 uc033hub.3 Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia. Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (PubMed:19253336, PubMed:23810713). Interacts with IFT88 (PubMed:19253336). Interacts with IFT57 and IFT70B (PubMed:23810713). Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Note=Basal body and ciliary axoneme in the chondrocytic ATDC-5 cell line. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K057-1; Sequence=Displayed; Name=2; IsoId=Q8K057-2; Sequence=VSP_027991, VSP_027992; Sequence=BAC98149.1; Type=Erroneous initiation; Evidence=; osteoblast differentiation chondrocyte differentiation molecular_function cytoplasm centrosome cytoskeleton cilium smoothened signaling pathway intraciliary transport particle B ciliary basal body intraciliary transport cell projection negative regulation of epithelial cell proliferation cilium assembly bone morphogenesis non-motile cilium assembly negative regulation of non-canonical Wnt signaling pathway uc033hub.1 uc033hub.2 uc033hub.3 
ENSMUST00000107816.5 Il12a ENSMUST00000107816.5 interleukin 12a, transcript variant 2 (from RefSeq NM_008351.4) ENSMUST00000107816.1 ENSMUST00000107816.2 ENSMUST00000107816.3 ENSMUST00000107816.4 IL12A Il12a Ll12a NM_008351 Q549G3 Q549G3_MOUSE uc008plv.1 uc008plv.2 uc008plv.3 uc008plv.4 uc008plv.5 uc008plv.6 Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites. Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12. Secreted Belongs to the IL-6 superfamily. positive regulation of T cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target cytokine activity interleukin-12 receptor binding extracellular region extracellular space immune response cell cycle arrest growth factor activity response to virus response to UV-B cell migration response to lipopolysaccharide negative regulation of interleukin-17 production positive regulation of interferon-gamma production positive regulation of natural killer cell activation positive regulation of mononuclear cell proliferation positive regulation of smooth muscle cell apoptotic process interleukin-12 beta subunit binding positive regulation of tyrosine phosphorylation of STAT protein interleukin-12 complex interleukin-27 binding positive regulation of cell adhesion positive regulation of natural killer cell mediated cytotoxicity protein heterodimerization activity negative regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation defense response to Gram-positive bacterium positive regulation of NK T cell activation extrinsic apoptotic signaling pathway cellular response to virus positive regulation of dendritic cell chemotaxis uc008plv.1 uc008plv.2 uc008plv.3 uc008plv.4 uc008plv.5 uc008plv.6 
ENSMUST00000107818.9 Ankrd40 ENSMUST00000107818.9 ankyrin repeat domain 40, transcript variant 1 (from RefSeq NM_027799.2) ANR40_MOUSE ENSMUST00000107818.1 ENSMUST00000107818.2 ENSMUST00000107818.3 ENSMUST00000107818.4 ENSMUST00000107818.5 ENSMUST00000107818.6 ENSMUST00000107818.7 ENSMUST00000107818.8 NM_027799 Q5SUE8 Q5SUF0 Q8R595 Q9CU71 uc007kyl.1 uc007kyl.2 uc007kyl.3 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5SUE8-1; Sequence=Displayed; Name=2; IsoId=Q5SUE8-2; Sequence=VSP_019555, VSP_019556; Name=3; IsoId=Q5SUE8-3; Sequence=VSP_019554, VSP_019557; molecular_function cellular_component biological_process uc007kyl.1 uc007kyl.2 uc007kyl.3 
ENSMUST00000107821.9 Luc7l3 ENSMUST00000107821.9 LUC7-like 3 (S. cerevisiae), transcript variant 5 (from RefSeq NM_001361575.1) Crop ENSMUST00000107821.1 ENSMUST00000107821.2 ENSMUST00000107821.3 ENSMUST00000107821.4 ENSMUST00000107821.5 ENSMUST00000107821.6 ENSMUST00000107821.7 ENSMUST00000107821.8 LC7L3_MOUSE NM_001361575 Q3U9D5 Q5SUF2 Q8BUJ5 Q921Z3 Q9CRS7 Q9CTY4 uc007kyi.1 uc007kyi.2 uc007kyi.3 Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity). May interact with SFRS1 and form homodimers. Interacts with JMJD6. Interacts with RBM25. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with RRP1B. Nucleus speckle Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5SUF2-1; Sequence=Displayed; Name=2; IsoId=Q5SUF2-2; Sequence=VSP_018138; Name=3; IsoId=Q5SUF2-3; Sequence=VSP_018139; Belongs to the Luc7 family. DNA binding mRNA binding nucleus nucleoplasm U1 snRNP mRNA splice site selection mRNA processing RNA splicing nuclear speck U2-type prespliceosome uc007kyi.1 uc007kyi.2 uc007kyi.3 
ENSMUST00000107824.9 Zcchc7 ENSMUST00000107824.9 zinc finger, CCHC domain containing 7 (from RefSeq NM_138590.4) B1AX39 D4Wsu132e ENSMUST00000107824.1 ENSMUST00000107824.2 ENSMUST00000107824.3 ENSMUST00000107824.4 ENSMUST00000107824.5 ENSMUST00000107824.6 ENSMUST00000107824.7 ENSMUST00000107824.8 NM_138590 Q3TZN5 Q8C915 Q9CYZ9 ZCHC7_MOUSE uc008srz.1 uc008srz.2 uc008srz.3 uc008srz.4 uc008srz.5 Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes (By similarity). Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B1AX39-1; Sequence=Displayed; Name=2; IsoId=B1AX39-3; Sequence=VSP_036901, VSP_036902; Sequence=AAI17021.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=AAI17023.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=AAI44775.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=BAC31499.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=BAE34173.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; nucleic acid binding nucleus nucleolus cytosol biological_process zinc ion binding metal ion binding uc008srz.1 uc008srz.2 uc008srz.3 uc008srz.4 uc008srz.5 
ENSMUST00000107843.11 Prmt1 ENSMUST00000107843.11 protein arginine N-methyltransferase 1, transcript variant 4 (from RefSeq NR_045521.1) ANM1_MOUSE ENSMUST00000107843.1 ENSMUST00000107843.10 ENSMUST00000107843.2 ENSMUST00000107843.3 ENSMUST00000107843.4 ENSMUST00000107843.5 ENSMUST00000107843.6 ENSMUST00000107843.7 ENSMUST00000107843.8 ENSMUST00000107843.9 Hrmt1l2 Mrmt1 NR_045521 Q99LS4 Q9JIF0 uc009gsg.1 uc009gsg.2 uc009gsg.3 uc009gsg.4 Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, FMR1, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4, SERBP1, RBM15, FOXO1, CHTOP and MAP3K5/ASK1 (PubMed:15327772, PubMed:19858291). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation (By similarity). May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway (By similarity). Methylates RBM15, promoting ubiquitination and degradation of RBM15 (By similarity). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:19858291). Methylates MAP3K5/ASK1 at 'Arg-85' and 'Arg-87' which promotes association of MAP3K5 with thioredoxin and negatively regulates MAP3K5 association with TRAF2, inhibiting MAP3K5 stimulation and MAP3K5-induced activation of JNK (By similarity). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1- dependent manner (By similarity). Plays a role in regulating alternative splicing in the heart (PubMed:30321814). Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA- COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48097; Evidence=; Reaction=L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48100, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:11990, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65280; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48101; Evidence=; Reaction=N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl- L-homocysteine; Xref=Rhea:RHEA:48104, Rhea:RHEA-COMP:11990, Rhea:RHEA-COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61897, ChEBI:CHEBI:65280; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48105; Evidence=; Homodimer and heterodimer with PRMT8. Homooctamer; individual homodimers associates to form a homooctamer. Individual homodimers can associate to form a homohexamer. Interacts with BTG1, BTG2 and IFNAR1. Interacts with ILF3 and SUPT5H. Interacts with and methylates FOXO1, leading to the nuclear retention of FOXO1 and the stimulation of FOXO1 transcriptional activity. Methylation of FOXO1 is increased upon oxidative stress (By similarity). Interacts with NFATC2IP. Interacts with and methylates CHTOP, thereby enabling the interaction of CHTOP with the 5FMC complex. Interacts with and probably methylates ATXN2L (By similarity). Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH (By similarity). Interacts with DHX9 (via RGG region) (By similarity). Interacts (via N-terminus) with HABP4 (By similarity). Interacts with MAP3K5/ASK1; the interaction results in MAP3K5 methylation by PRMT1 which inhibits MAP3K5 activation (By similarity). Interacts with TRIM48; the interaction results in ubiquitination of PRMT1 by TRIM48, leading to PRMT1 proteasomal degradation and activation of MAP3K5 (By similarity). Q9JIF0; Q14DJ8: Axin1; NbExp=3; IntAct=EBI-519055, EBI-4312125; Q9JIF0; Q9CY57: Chtop; NbExp=8; IntAct=EBI-519055, EBI-6393116; Q9JIF0; Q60749: Khdrbs1; NbExp=2; IntAct=EBI-519055, EBI-519077; Q9JIF0; O35182: Smad6; NbExp=3; IntAct=EBI-519055, EBI-4321242; Q9JIF0-1; Q14DJ8: Axin1; NbExp=2; IntAct=EBI-4312217, EBI-4312125; Q9JIF0-3; Q14DJ8: Axin1; NbExp=2; IntAct=EBI-4422829, EBI-4312125; Nucleus cleus, nucleoplasm Cytoplasm, cytosol Cytoplasm Note=Mostly found in the cytoplasm (PubMed:19858291). Colocalizes with CHTOP within the nucleus (PubMed:19858291). Low levels detected also in the chromatin fraction (PubMed:22872859). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9JIF0-1; Sequence=Displayed; Name=2; IsoId=Q9JIF0-2; Sequence=VSP_005210; Name=3; IsoId=Q9JIF0-3; Sequence=VSP_005211; Expressed in the heart where it is detected in both cardiomyocytes and non-myocytes (at protein level). Polyubiquitinated at Lys-145 by the SCF(FBXL17) complex, leading to its subsequent degradation (PubMed:28883095). Ubiquitination is regulated by acetylation at Lys-228 and Lys-233 (PubMed:28883095). Polyubiquitinated by E3 ubiquitin-protein ligase TRIM48, leading to suppression of MAP3K5/ASK1 methylation and subsequent MAP3K5 activation (By similarity). Acetylation at Lys-228 and Lys-233 regulates ubiquitination by the SCF(FBXL17) complex. Acetylated at Lys-233 by p300/EP300. Deacetylated at Lys-228 and Lys-233 by SIRT1. Conditional knockout in cardiomyocytes results in dilated cardiomyopathy in juveniles and death within 60 days of birth with aberrant splicing occurring in a number of genes including Ktn1, Lmo7, Mef2a, Tmed2, Snap23, Sorbs1 and Ttn. Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. in utero embryonic development protein binding nucleus nucleoplasm cytoplasm cytosol protein methylation methyltransferase activity N-methyltransferase activity protein methyltransferase activity positive regulation of cell proliferation methyl-CpG binding histone-arginine N-methyltransferase activity membrane protein-arginine N-methyltransferase activity [cytochrome c]-arginine N-methyltransferase activity histone methylation transferase activity peptidyl-arginine methylation enzyme binding peptidyl-arginine methylation, to asymmetrical-dimethyl arginine snoRNP binding neuron projection development methylation macromolecular complex methylosome protein-arginine omega-N monomethyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity peptidyl-arginine omega-N-methylation histone methyltransferase activity identical protein binding histone H4-R3 methylation histone methyltransferase activity (H4-R3 specific) positive regulation of erythrocyte differentiation regulation of megakaryocyte differentiation negative regulation of megakaryocyte differentiation positive regulation of hemoglobin biosynthetic process mitogen-activated protein kinase p38 binding protein homooligomerization positive regulation of p38MAPK cascade S-adenosyl-L-methionine binding uc009gsg.1 uc009gsg.2 uc009gsg.3 uc009gsg.4 
ENSMUST00000107851.10 Clta ENSMUST00000107851.10 clathrin light chain A, transcript variant 7 (from RefSeq NM_001369157.1) B1AWD9 B1AWD9_MOUSE Clta ENSMUST00000107851.1 ENSMUST00000107851.2 ENSMUST00000107851.3 ENSMUST00000107851.4 ENSMUST00000107851.5 ENSMUST00000107851.6 ENSMUST00000107851.7 ENSMUST00000107851.8 ENSMUST00000107851.9 NM_001369157 uc008sri.1 uc008sri.2 uc008sri.3 uc008sri.4 Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.3148290.1, SRR7345562.785694.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Cytoplasmic vesicle membrane ; Peripheral membrane protein ytoplasmic side Membrane, coated pit ; Peripheral membrane protein ; Cytoplasmic side Note=Cytoplasmic face of coated pits and vesicles. Belongs to the clathrin light chain family. structural molecule activity clathrin-coated pit intracellular protein transport endocytosis membrane vesicle-mediated transport clathrin coat clathrin coat of trans-Golgi network vesicle clathrin coat of coated pit clathrin-coated vesicle cytoplasmic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle clathrin heavy chain binding peptide binding macromolecular complex binding clathrin coat assembly GTPase binding clathrin complex presynaptic endocytic zone membrane uc008sri.1 uc008sri.2 uc008sri.3 uc008sri.4 
ENSMUST00000107853.8 Mbtd1 ENSMUST00000107853.8 mbt domain containing 1, transcript variant 3 (from RefSeq NM_001363336.1) ENSMUST00000107853.1 ENSMUST00000107853.2 ENSMUST00000107853.3 ENSMUST00000107853.4 ENSMUST00000107853.5 ENSMUST00000107853.6 ENSMUST00000107853.7 MBTD1_MOUSE Mbtd1 NM_001363336 Q6P3F0 Q6P5G3 Q8VE12 uc288bjx.1 uc288bjx.2 Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me. Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR). Monomer. Component of the NuA4 histone acetyltransferase complex. Interacts with EPC1; interaction is direct and promotes recruitment of MBTD1 into the NuA4 histone acetyltransferase complex. Nucleus Chromosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P5G3-1; Sequence=Displayed; Name=2; IsoId=Q6P5G3-2; Sequence=VSP_030119, VSP_030120; Sequence=AAH20018.1; Type=Erroneous initiation; Evidence=; nucleus chromatin organization regulation of transcription, DNA-templated zinc ion binding methylated histone binding metal ion binding embryonic skeletal system development uc288bjx.1 uc288bjx.2 
ENSMUST00000107857.11 Ap2a1 ENSMUST00000107857.11 adaptor-related protein complex 2, alpha 1 subunit, transcript variant 2 (from RefSeq NM_001077264.1) AP2A1_MOUSE Adtaa Clapa1 ENSMUST00000107857.1 ENSMUST00000107857.10 ENSMUST00000107857.2 ENSMUST00000107857.3 ENSMUST00000107857.4 ENSMUST00000107857.5 ENSMUST00000107857.6 ENSMUST00000107857.7 ENSMUST00000107857.8 ENSMUST00000107857.9 NM_001077264 P17426 uc009grw.1 uc009grw.2 uc009grw.3 Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L- [LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non- clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide- containing lipids, positioning AP-2 on the membrane. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with HIP1 and RAB11FIP2 (By similarity). Interacts with SLC12A5 (PubMed:18625303). Interacts with clathrin (PubMed:7559550). Interacts with SGIP1 (PubMed:17626015). Interacts with RFTN1 (By similarity). Interacts with KIAA1107 (PubMed:29262337). Interacts with PICALM (By similarity). Together with AP2B1 and AP2M1, it interacts with ADAM10; this interaction facilitates ADAM10 endocytosis from the plasma membrane during long-term potentiation in hippocampal neurons (PubMed:23676497). Interacts with ABCB11; this interaction regulates cell membrane expression of ABCB11 through its internalization in a clathrin-dependent manner and its subsequent degradation (By similarity). Probably interacts with ACE2 (via endocytic sorting signal motif); the interaction is inhibited by ACE2 phosphorylation (By similarity). P17426; Q01097: Grin2b; NbExp=2; IntAct=EBI-775189, EBI-400125; Cell membrane Membrane, coated pit ; Peripheral membrane protein ; Cytoplasmic side Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=P17426-1; Sequence=Displayed; Name=B; IsoId=P17426-2; Sequence=VSP_000162; Expressed in the brain (at protein level) (PubMed:23676497). Isoform A: Expressed only in neuronal tissue and skeletal muscle. Isoform B: Widely expressed. Belongs to the adaptor complexes large subunit family. protein binding plasma membrane clathrin-coated pit intracellular protein transport endocytosis protein C-terminus binding positive regulation of neuron projection development protein transport membrane vesicle-mediated transport basolateral plasma membrane apical plasma membrane protein kinase binding membrane coat AP-2 adaptor complex clathrin adaptor complex clathrin-coated vesicle secretory granule filopodium tip macromolecular complex clathrin adaptor activity macromolecular complex binding positive regulation of receptor-mediated endocytosis low-density lipoprotein particle receptor binding clathrin-dependent endocytosis negative regulation of hyaluronan biosynthetic process uc009grw.1 uc009grw.2 uc009grw.3 
ENSMUST00000107860.3 Or13c7 ENSMUST00000107860.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9QZ22) ENSMUST00000107860.1 ENSMUST00000107860.2 OR37A Olfr155 Or13c7 Q9QZ22 Q9QZ22_MOUSE or37a uc290mib.1 uc290mib.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc290mib.1 uc290mib.2 
ENSMUST00000107862.3 Or13j1 ENSMUST00000107862.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9QZ18) ENSMUST00000107862.1 ENSMUST00000107862.2 OR17 Olfr71 Or13j1 Q9QZ18 Q9QZ18_MOUSE or17 uc290mhs.1 uc290mhs.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc290mhs.1 uc290mhs.2 
ENSMUST00000107865.9 Tmem8b ENSMUST00000107865.9 transmembrane protein 8B, transcript variant 5 (from RefSeq NM_001368842.1) B1AWJ5 B9EJV2 ENSMUST00000107865.1 ENSMUST00000107865.2 ENSMUST00000107865.3 ENSMUST00000107865.4 ENSMUST00000107865.5 ENSMUST00000107865.6 ENSMUST00000107865.7 ENSMUST00000107865.8 NM_001368842 TMM8B_MOUSE uc008sqv.1 uc008sqv.2 uc008sqv.3 May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion (By similarity). May interact with EZR. Cell membrane ; Multi-pass membrane protein Cytoplasm Nucleus Mitochondrion Endoplasmic reticulum Note=Also detected in mitochondrion and endoplasmic reticulum. N-glycosylated. Belongs to the TMEM8 family. molecular_function nucleus cytoplasm mitochondrion endoplasmic reticulum plasma membrane cell adhesion cell-matrix adhesion cell surface membrane integral component of membrane regulation of growth uc008sqv.1 uc008sqv.2 uc008sqv.3 
ENSMUST00000107884.3 Msmp ENSMUST00000107884.3 microseminoprotein, prostate associated (from RefSeq NM_001099314.1) B1AWI6 ENSMUST00000107884.1 ENSMUST00000107884.2 MSMP_MOUSE NM_001099314 Psmp uc008sql.1 uc008sql.2 Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and lymphocytes but not neutrophils (By similarity). Secreted Belongs to the beta-microseminoprotein family. molecular_function extracellular region extracellular space cytoplasm biological_process uc008sql.1 uc008sql.2 
ENSMUST00000107886.9 Rgp1 ENSMUST00000107886.9 RAB6A GEF compex partner 1 (from RefSeq NM_172866.3) B1AWI4 ENSMUST00000107886.1 ENSMUST00000107886.2 ENSMUST00000107886.3 ENSMUST00000107886.4 ENSMUST00000107886.5 ENSMUST00000107886.6 ENSMUST00000107886.7 ENSMUST00000107886.8 Kiaa0258 NM_172866 Q6ZQF1 Q8BHT7 RGP1_MOUSE Rgp1 uc008sqj.1 uc008sqj.2 uc008sqj.3 The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Forms a complex with RIC1; the interaction enhances RAB6A GTPase activity. Interacts with RIC1. Interacts with RAB6A; the interaction is direct with a preference for RAB6A-GDP. Interacts with RAB33B. Cytoplasm, cytosol Membrane Belongs to the RGP1 family. Sequence=BAC97913.1; Type=Erroneous initiation; Evidence=; Golgi membrane guanyl-nucleotide exchange factor activity cytoplasm cytosol plasma membrane membrane Rab guanyl-nucleotide exchange factor activity Rab GTPase binding macromolecular complex RIC1-RGP1 guanyl-nucleotide exchange factor complex retrograde transport, endosome to Golgi positive regulation of GTPase activity negative regulation of cellular protein catabolic process uc008sqj.1 uc008sqj.2 uc008sqj.3 
ENSMUST00000107894.8 Dgke ENSMUST00000107894.8 Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11287665). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11287665). Also plays an important role in the biosynthesis of complex lipids (By similarity). Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle (PubMed:11287665, PubMed:19744926). Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (By similarity). (from UniProt Q9R1C6) AK049335 DGKE_MOUSE ENSMUST00000107894.1 ENSMUST00000107894.2 ENSMUST00000107894.3 ENSMUST00000107894.4 ENSMUST00000107894.5 ENSMUST00000107894.6 ENSMUST00000107894.7 Q5SU69 Q9R1C6 uc007kwd.1 uc007kwd.2 uc007kwd.3 Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11287665). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11287665). Also plays an important role in the biosynthesis of complex lipids (By similarity). Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle (PubMed:11287665, PubMed:19744926). Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (By similarity). Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10273; Evidence=; Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40335, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:72864, ChEBI:CHEBI:77096, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40336; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40324; Evidence=; Reaction=1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:40331, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77093, ChEBI:CHEBI:77094, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40332; Evidence=; Reaction=1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40351, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77125, ChEBI:CHEBI:77126, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40352; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40339, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77097, ChEBI:CHEBI:77098, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40340; Evidence=; Reaction=1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP = 1,2-di- (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40355, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77127, ChEBI:CHEBI:77128, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40356; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328; Evidence=; Lipid metabolism; glycerolipid metabolism. Membrane ; Single- pass membrane protein Cytoplasm Highly expressed in brain and heart (PubMed:11287665). In brain, highly expressed in Purkinje cells of the cerebellum, pyramidal cells of the hippocampus, mitral cells of the olfactory bulb, and neurons of the substantia nigra (PubMed:11287665). Lower expression in neurons of the thalamus, superior olive, and lateral reticular nucleus is also detected (PubMed:11287665). Expressed in platelets (PubMed:23542698). Homozygous knockout mice are normal, reproduce and behave normally. No gross or histological abnormalities in major organs, including the brain are observed (PubMed:11287665). The phosphatidylinositol 4,5- bisphosphate-signaling pathway in cerebral cortex and long-term potentiation are affected (PubMed:11287665). Belongs to the eukaryotic diacylglycerol kinase family. nucleotide binding NAD+ kinase activity diacylglycerol kinase activity ATP binding nucleus cytoplasm cytosol signal transduction protein kinase C-activating G-protein coupled receptor signaling pathway membrane integral component of membrane kinase activity phosphorylation transferase activity intracellular signal transduction diacylglycerol metabolic process glycerolipid metabolic process lipid phosphorylation metal ion binding modulation of synaptic transmission glutamatergic synapse uc007kwd.1 uc007kwd.2 uc007kwd.3 
ENSMUST00000107896.10 Trim25 ENSMUST00000107896.10 tripartite motif-containing 25 (from RefSeq NM_009546.2) ENSMUST00000107896.1 ENSMUST00000107896.2 ENSMUST00000107896.3 ENSMUST00000107896.4 ENSMUST00000107896.5 ENSMUST00000107896.6 ENSMUST00000107896.7 ENSMUST00000107896.8 ENSMUST00000107896.9 Efp NM_009546 Q5SU70 Q61510 TRI25_MOUSE Zfp147 Znf147 uc007kwc.1 uc007kwc.2 uc007kwc.3 Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1. Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection. Mediates 'Lys-63'-linked polyubiquitination of IFIH1. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (By similarity). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (PubMed:29125140). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA. Mediates also the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Reaction=ATP + [ISG15] + [protein]-lysine = AMP + diphosphate + [protein]-N-ISGyllysine.; EC=6.3.2.n3; Evidence=; Protein modification; protein ubiquitination. Forms homodimers (By similarity). Interacts (via SPRY domain) with RIGI (via CARD domain). Interacts with ZFHX3. Interacts with NLRP12; this interaction reduces the E3 ubiquitin ligase TRIM25- mediated 'Lys-63'-linked RIGI activation. Interacts with the KHDC3L/FILIA-OOEP/FLOPED scaffold complex and BLM at DNA replication forks (PubMed:29125140). Interacts with RTN3; this interaction prevents RIGI ubiquitination (By similarity). Interacts with YWHAE (By similarity). Cytoplasm Cytoplasm, Stress granule Nucleus Note=Localized to DNA replication forks. Ubiquitous. The RING-type zinc finger is important for ISG15 E3 ligase activity and autoISGylation. AutoISGylation negatively regulates ISG15 E3 ligase activity. The C-terminal B30.2/SPRY domain interacts with the first N- terminal CARD domain of RIGI. Auto-ISGylated. immune system process nucleoplasm cytoplasm cytosol ubiquitin-dependent protein catabolic process protein monoubiquitination protein ubiquitination nuclear body transferase activity ligase activity ER-associated ubiquitin-dependent protein catabolic process response to vitamin D positive regulation of I-kappaB kinase/NF-kappaB signaling response to estrogen innate immune response regulation of viral entry into host cell negative regulation of viral entry into host cell metal ion binding positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity defense response to virus ubiquitin protein ligase activity regulation of viral release from host cell negative regulation of viral release from host cell cellular response to leukemia inhibitory factor uc007kwc.1 uc007kwc.2 uc007kwc.3 
ENSMUST00000107899.10 Myh14 ENSMUST00000107899.10 myosin, heavy polypeptide 14, transcript variant 3 (from RefSeq NM_028021.3) B3F3T1 ENSMUST00000107899.1 ENSMUST00000107899.2 ENSMUST00000107899.3 ENSMUST00000107899.4 ENSMUST00000107899.5 ENSMUST00000107899.6 ENSMUST00000107899.7 ENSMUST00000107899.8 ENSMUST00000107899.9 MYH14_MOUSE NM_028021 Q6URW6 Q80V64 Q80ZE6 uc009gqi.1 uc009gqi.2 uc009gqi.3 uc009gqi.4 Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=NM II-C1; IsoId=Q6URW6-1; Sequence=Displayed; Name=2; Synonyms=NM II-C0; IsoId=Q6URW6-2; Sequence=VSP_014633; Name=3; Synonyms=NM II-C2; IsoId=Q6URW6-3; Sequence=VSP_014633, VSP_044759; Highest levels in lung, kidney, brain and colon, very low levels in liver and bladder and no expression in spleen or seminal vesicle (at protein level). Isoform 1 is expressed in liver, kidney and testis with low levels in skeletal muscle and heart. Isoform 1 and isoform 2 are expressed in brain and lung. Isoform 2 is the main isoform expressed in skeletal muscle and heart. Isoform 3 is limited to brain stem, cerebellum and spinal cord. Widely expressed throughout the embryo at 11.5 dpc. Enhanced expression in the developing pituitary at 11.5 dpc. Expressed in developing lung from 13.5 dpc. At 16.5 dpc, confined to airway epithelial cells, developing sensory area of the cochlea and intestinal epithelial cells, particularly concentrated at their apical border. The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Survival to adulthood with no obvious defects in brain structure, lung and heart development and no evidence for defective cell division. Deletion in animals expressing only 12% of wild-type amounts of Myh10 results in an increase in cardiac myocyte hypertrophy and interstitial fibrosis compared with the Myh10 hypomorphic animal. [Isoform 1]: Requires phosphorylation of the myosin regulatory light chain for activity. [Isoform 2]: Requires phosphorylation of the myosin regulatory light chain for activity. [Isoform 3]: Constitutively active isoform which does not require phosphorylation of the regulatory myosin light chain for activity. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. microfilament motor activity nucleotide binding stress fiber skeletal muscle contraction motor activity actin binding calmodulin binding ATP binding cytoplasm brush border skeletal muscle tissue development sensory perception of sound regulation of cell shape myosin complex myosin II complex ATPase activity neuronal action potential actin filament-based movement axon growth cone actin-dependent ATPase activity actomyosin structure organization actomyosin myelin sheath actin filament binding mitochondrion morphogenesis vocalization behavior myosin II filament uc009gqi.1 uc009gqi.2 uc009gqi.3 uc009gqi.4 
ENSMUST00000107907.10 Kcnc3 ENSMUST00000107907.10 potassium voltage gated channel, Shaw-related subfamily, member 3, transcript variant 1 (from RefSeq NM_008422.3) D3YZV2 E9Q5E5 ENSMUST00000107907.1 ENSMUST00000107907.2 ENSMUST00000107907.3 ENSMUST00000107907.4 ENSMUST00000107907.5 ENSMUST00000107907.6 ENSMUST00000107907.7 ENSMUST00000107907.8 ENSMUST00000107907.9 KCNC3_MOUSE NM_008422 Q62088 Q63959 uc009gqg.1 uc009gqg.2 uc009gqg.3 Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:18539595, PubMed:26997484, PubMed:24218544). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells (PubMed:15217387, PubMed:18448641, PubMed:24218544). Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (PubMed:24218544). Required for normal motor function (PubMed:16923152, PubMed:18448641). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484). Homotetramer. Heterotetramer with KCNC1 (By similarity). Interacts (via C-terminus) with HAX1. Identified in a complex with ACTR3, a subunit of the Arp2/3 complex; this interaction is indirect and depends on the presence of HAX1. Interaction with HAX1 modulates channel gating (PubMed:26997484). Cell membrane ulti-pass membrane protein Presynaptic cell membrane ; Multi-pass membrane protein Perikaryon Cell projection, axon Cell projection, dendrite Cell projection, dendritic spine membrane ; Multi-pass membrane protein Cytoplasm, cell cortex Cytoplasm, cytoskeleton Note=Detected on Purkinje cell dendritic spines, positioned perisynaptically but also in extrasynaptic positions along the spine membranes (By similarity). Detected at presynaptic calices of Held (PubMed:26997484). Colocalizes with the cortical actin cytoskeleton and the Arp2/3 complex (By similarity). Detected on Purkinje cells in the dentate, interposed and medial nucleus in cerebellum (PubMed:15217387, PubMed:18448641). Detected in brainstem (PubMed:18539595). Detected at calyces of Held in the auditory brain stem (at protein level) (PubMed:26997484). Isoform KV3.3B is highly enriched in the brain, particularly in the cerebellum, where its expression is confined to Purkinje cells and deep cerebellar nuclei. Isoform KV3.3A is not expressed in cerebellum. Expression begins in cerebellar Purkinje cells between postnatal day 8 (P8) and P10 and continues through adulthood. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The cytoplasmic N-terminus mediates N-type inactivation. The C-terminal cytoplasmic tail contributes to the regulation of channel inactivation and to the interaction with HAX1 and the Arp2/3 complex. N-glycosylated. Mice lacking both Kcnc3 and Kcnc1 are born at the expected Mendelian rate, but the pups do not thrive and all die about 26 days after birth when kept together with other littermates. Their failure to thrive may be due to motor problems; mutant pups survive when fed separately, but 45 days after birth their body weight is only 50 to 60 % of that of wild-type (PubMed:11517255). They appear uncoordinated and display severe ataxia, myoclonus and spontaneous whole-body muscle jerks, but display no obvious alterations in brain morphology (PubMed:11517255, PubMed:15217387, PubMed:16923152). Mice lacking only Kcnc3 still display ataxic gait and decreased motor skill, but to a lesser degree than mice lacking both Kcnc3 and Kcnc1 (PubMed:16923152, PubMed:18448641). Purkinje cell-specific expression of Kcnc3 restores normal motor skills (PubMed:18448641). Mutant mice are also much more sensitive to ethanol and fall sideways at ethanol concentrations that have no effect on wild-type mice (PubMed:11517255). They display increased locomotor and exploratory activity (PubMed:11517255, PubMed:15217387). Mice lacking Kcnc3 or both Kcnc3 and Kcnc1 are resistant to the tremorogenic agent harmaline (PubMed:15217387). Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily. Sequence=CAA43209.1; Type=Frameshift; Evidence=; Sequence=CAA43209.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Incorrect C-terminus.; Evidence=; ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity cytoplasm cytoskeleton plasma membrane cell cortex ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane cell junction axon dendrite axolemma neuromuscular junction dendrite membrane dendritic spine membrane neuronal cell body membrane regulation of ion transmembrane transport presynaptic membrane cell projection neuronal cell body perikaryon axon terminus synapse regulation of neurotransmitter secretion protein homooligomerization protein tetramerization transmembrane transport potassium ion transmembrane transport glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane uc009gqg.1 uc009gqg.2 uc009gqg.3 
ENSMUST00000107909.8 Msi2 ENSMUST00000107909.8 musashi RNA-binding protein 2, transcript variant 4 (from RefSeq NM_001363195.1) ENSMUST00000107909.1 ENSMUST00000107909.2 ENSMUST00000107909.3 ENSMUST00000107909.4 ENSMUST00000107909.5 ENSMUST00000107909.6 ENSMUST00000107909.7 MSI2H_MOUSE Msi2h NM_001363195 Q8BQ90 Q920Q6 Q920Q7 uc007kvm.1 uc007kvm.2 uc007kvm.3 uc007kvm.4 RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system. Cytoplasm Note=Associated with polysomes. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Msi2L; IsoId=Q920Q6-1; Sequence=Displayed; Name=2; Synonyms=Msi2S; IsoId=Q920Q6-2; Sequence=VSP_011173; Name=3; IsoId=Q920Q6-3; Sequence=VSP_011172, VSP_011174; Ubiquitous. Expressed in proliferating neural precursor cells. Up-regulated in astrocytes after brain injury. Phosphorylated. Belongs to the Musashi family. nucleic acid binding RNA binding single-stranded RNA binding nucleus cytoplasm polysome poly(U) RNA binding stem cell development ribonucleoprotein complex uc007kvm.1 uc007kvm.2 uc007kvm.3 uc007kvm.4 
ENSMUST00000107913.10 Tpm2 ENSMUST00000107913.10 tropomyosin 2, beta, transcript variant Tpm2.2 (from RefSeq NM_009416.4) ENSMUST00000107913.1 ENSMUST00000107913.2 ENSMUST00000107913.3 ENSMUST00000107913.4 ENSMUST00000107913.5 ENSMUST00000107913.6 ENSMUST00000107913.7 ENSMUST00000107913.8 ENSMUST00000107913.9 NM_009416 P02560 P46901 P58774 TPM2_MOUSE Tpm-2 uc008sqd.1 uc008sqd.2 uc008sqd.3 uc008sqd.4 This gene belongs to the tropomyosin family which encodes proteins that bind to actin filaments and stabilize them by regulating access to actin modifying proteins. The encoded protein is a high molecular weight tropomyosin expressed in slow skeletal muscle. In humans, mutations in this gene are associated with nemaline myopathy, cap disease and distal arthrogryposis syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]. Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (PubMed:16094730). Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain. Cytoplasm, cytoskeleton Note=Associates with F-actin stress fibers. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Skeletal muscle, TB1-3; IsoId=P58774-1; Sequence=Displayed; Name=2; Synonyms=non-muscle, Fibroblast, TM-1; IsoId=P58774-2; Sequence=VSP_006597, VSP_006598; The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity. Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization. Belongs to the tropomyosin family. actin binding structural constituent of cytoskeleton protein binding cytoplasm cytoskeleton muscle thin filament tropomyosin actin filament muscle contraction actin filament organization actin cytoskeleton identical protein binding protein homodimerization activity regulation of ATPase activity protein heterodimerization activity actin filament binding uc008sqd.1 uc008sqd.2 uc008sqd.3 uc008sqd.4 
ENSMUST00000107924.3 Selenot ENSMUST00000107924.3 selenoprotein T (from RefSeq NM_001040396.3) A2RTC6 ENSMUST00000107924.1 ENSMUST00000107924.2 NM_001040396 O95904 P62342 Q8CHV4 Q9CZ45 Q9NZJ3 SELT_MOUSE Selenot Selt uc008phx.1 uc008phx.2 uc008phx.3 uc008phx.4 uc008phx.5 This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. A pseudogene of this locus has been identified on chromosome 8. [provided by RefSeq, Aug 2017]. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.105941.1, AK047958.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress and cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (PubMed:19935881). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP- induced insulin secretion (PubMed:23913443). Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9; Evidence=; Endoplasmic reticulum membrane ; Single-pass membrane protein Ubiquitous. Highly expressed in the endocrine pancreas (PubMed:23913443). Expressed at low levels in the adult brain (PubMed:26866473). Rapidly induced by ADCYAP1/PACAP neuropeptide (PubMed:23913443). In striatum neurons and astrocytes, induced by Parkinson disease-inducing neurotoxins such as 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) or rotenone (PubMed:26866473). May contain a selenide-sulfide bond between Cys-46 and Sec-49. This bond is speculated to serve as redox-active pair (By similarity). Knockout embryos die before E8 (PubMed:26866473). Male conditional pancreatic beta-cell knockout mice display impaired glucose tolerance with an increased number of smaller islets compared to wild-type littermates (PubMed:23913443). Brain conditional knockout mice treated with Parkinson disease-inducing neurotoxins such as 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) rapidly show tremor and absence of movement to die within 2h after treatment (PubMed:26866473). Belongs to the SelWTH family. Selenoprotein T subfamily. Sequence=AAH19970.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH38867.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC55254.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC55259.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC55261.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; thioredoxin-disulfide reductase activity endoplasmic reticulum endoplasmic reticulum membrane positive regulation of cytosolic calcium ion concentration response to glucose membrane integral component of membrane oxidoreductase activity pancreas development insulin secretion involved in cellular response to glucose stimulus glucose homeostasis cell redox homeostasis oxidation-reduction process positive regulation of growth hormone secretion cellular oxidant detoxification uc008phx.1 uc008phx.2 uc008phx.3 uc008phx.4 uc008phx.5 
ENSMUST00000107927.5 Garin5a ENSMUST00000107927.5 golgi associated RAB2 interactor 5A, transcript variant 1 (from RefSeq NM_028169.2) A1L3C1 E9QKI6 ENSMUST00000107927.1 ENSMUST00000107927.2 ENSMUST00000107927.3 ENSMUST00000107927.4 Fam71e1 GAR5A_MOUSE Garil5 Garin5a NM_028169 Q0P5X9 uc009gpu.1 uc009gpu.2 uc009gpu.3 uc009gpu.4 RAB2B effector protein which promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis. Interacts (via N-terminus) with RAB2B (in GTP-bound form). Golgi apparatus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A1L3C1-1; Sequence=Displayed; Name=2; IsoId=A1L3C1-2; Sequence=VSP_033761; Expressed in testis (at protein level). Detected in testis at 28 days after birth and expression is maintained (PubMed:28742876). Expressed by testicular cells and testicular sperm but not mature sperm (PubMed:28742876). Belongs to the GARIN family. molecular_function biological_process uc009gpu.1 uc009gpu.2 uc009gpu.3 uc009gpu.4 
ENSMUST00000107929.10 Cimip2b ENSMUST00000107929.10 ciliary microtubule inner protein 2B, transcript variant 3 (from RefSeq NM_001369077.1) A2AIP0 A2AIP2 B0R005 B0R006 CMI2B_MOUSE ENSMUST00000107929.1 ENSMUST00000107929.2 ENSMUST00000107929.3 ENSMUST00000107929.4 ENSMUST00000107929.5 ENSMUST00000107929.6 ENSMUST00000107929.7 ENSMUST00000107929.8 ENSMUST00000107929.9 Fam166b NM_001369077 Q8C6T2 Q8CDW8 uc290mei.1 uc290mei.2 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Cytoplasm, cytoskeleton, cilium axoneme Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A2AIP0-1; Sequence=Displayed; Name=2; IsoId=A2AIP0-2; Sequence=VSP_034440; Name=3; IsoId=A2AIP0-3; Sequence=VSP_034442, VSP_034443; Name=4; IsoId=A2AIP0-4; Sequence=VSP_034440, VSP_034442, VSP_034443; Name=5; IsoId=A2AIP0-5; Sequence=VSP_034441; Expressed in airway epithelial cells. Belongs to the CIMIP2 family. molecular_function cellular_component biological_process uc290mei.1 uc290mei.2 
ENSMUST00000107933.8 1700008O03Rik ENSMUST00000107933.8 RIKEN cDNA 1700008O03 gene (from RefSeq NM_027049.1) CS081_MOUSE D3Z070 ENSMUST00000107933.1 ENSMUST00000107933.2 ENSMUST00000107933.3 ENSMUST00000107933.4 ENSMUST00000107933.5 ENSMUST00000107933.6 ENSMUST00000107933.7 NM_027049 Q9DAJ9 uc009gpf.1 uc009gpf.2 uc009gpf.3 uc009gpf.4 Sequence=BAB24236.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc009gpf.1 uc009gpf.2 uc009gpf.3 uc009gpf.4 
ENSMUST00000107938.8 Shank1 ENSMUST00000107938.8 SH3 and multiple ankyrin repeat domains 1 (from RefSeq NM_001034115.1) D3YZU1 ENSMUST00000107938.1 ENSMUST00000107938.2 ENSMUST00000107938.3 ENSMUST00000107938.4 ENSMUST00000107938.5 ENSMUST00000107938.6 ENSMUST00000107938.7 NM_001034115 SHAN1_MOUSE uc012fjo.1 uc012fjo.2 uc012fjo.3 Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function (By similarity). May homomultimerize via its SAM domain. Interacts with the C- terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2. Interacts with IGSF9 (By similarity). Interacts with HOMER1 and HOMER3 (By similarity). D3YZU1; Q61625: Grid2; NbExp=3; IntAct=EBI-2314988, EBI-2794106; D3YZU1; Q9EP53: Tsc1; NbExp=2; IntAct=EBI-2314988, EBI-1202690; Cytoplasm Synapse Postsynaptic density Note=Colocalizes with alpha- latrotoxin receptor 1. In brain, highly expressed in cortex, hippocampus and cerebellum. Belongs to the SHANK family. cytoplasm plasma membrane nervous system development synapse assembly long-term memory protein C-terminus binding associative learning postsynaptic density membrane SH3 domain binding NMDA selective glutamate receptor complex cell junction cell differentiation receptor signaling complex scaffold activity GKAP/Homer scaffold activity dendrite adult behavior somatostatin receptor binding negative regulation of actin filament bundle assembly social behavior ionotropic glutamate receptor binding protein localization to synapse olfactory behavior identical protein binding neuron projection dendritic spine neuron spine macromolecular complex binding synapse postsynaptic membrane habituation brain morphogenesis neuromuscular process controlling balance determination of affect synaptic growth at neuromuscular junction positive regulation of synaptic transmission, glutamatergic righting reflex synapse maturation excitatory synapse long-term synaptic potentiation dendritic spine morphogenesis positive regulation of dendritic spine development macromolecular complex assembly ankyrin repeat binding vocalization behavior postsynaptic density assembly scaffold protein binding structural constituent of postsynaptic density glutamatergic synapse maintenance of postsynaptic density structure regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential ionotropic glutamate receptor complex uc012fjo.1 uc012fjo.2 uc012fjo.3 
ENSMUST00000107942.9 Atp8b5 ENSMUST00000107942.9 ATPase, class I, type 8B, member 5 (from RefSeq NM_177195.3) A2AIL8 A3FIN4 AT8B5_MOUSE ENSMUST00000107942.1 ENSMUST00000107942.2 ENSMUST00000107942.3 ENSMUST00000107942.4 ENSMUST00000107942.5 ENSMUST00000107942.6 ENSMUST00000107942.7 ENSMUST00000107942.8 Feta NM_177195 Q8BVE9 Q8BVS7 uc008spl.1 uc008spl.2 uc008spl.3 P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in phospholid transport across membranes and in acrosome formation. Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A3FIN4-1; Sequence=Displayed; Name=2; IsoId=A3FIN4-2; Sequence=VSP_031844, VSP_031845; Name=3; IsoId=A3FIN4-3; Sequence=VSP_031846, VSP_031847; Highly expressed in testis. Not detected in testis until 18 days postpartum. At 22 days postpartum, levels increase and remain constant during adulthood. During spermatogenesis, expressed from pachytene spermatocytes to mature sperm. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. nucleotide binding magnesium ion binding acrosomal vesicle acrosomal membrane ATP binding Golgi apparatus plasma membrane lipid transport Golgi organization phospholipid transport membrane integral component of membrane cytoplasmic vesicle phospholipid translocation metal ion binding phosphatidylethanolamine-translocating ATPase activity uc008spl.1 uc008spl.2 uc008spl.3 
ENSMUST00000107968.10 Klk6 ENSMUST00000107968.10 Klk6 (from geneSymbol) BC031119 ENSMUST00000107968.1 ENSMUST00000107968.2 ENSMUST00000107968.3 ENSMUST00000107968.4 ENSMUST00000107968.5 ENSMUST00000107968.6 ENSMUST00000107968.7 ENSMUST00000107968.8 ENSMUST00000107968.9 Klk6 Prss18 Q91Y82 Q91Y82_MOUSE uc009gnu.1 uc009gnu.2 uc009gnu.3 uc009gnu.4 serine-type endopeptidase activity extracellular region cytoplasm proteolysis peptidase activity serine-type peptidase activity regulation of neuron projection development hydrolase activity secretory granule positive regulation of G-protein coupled receptor protein signaling pathway uc009gnu.1 uc009gnu.2 uc009gnu.3 uc009gnu.4 
ENSMUST00000107970.8 Klk12 ENSMUST00000107970.8 kallikrein related-peptidase 12, transcript variant 1 (from RefSeq NM_001415883.1) B2RVZ0 B2RVZ0_MOUSE ENSMUST00000107970.1 ENSMUST00000107970.2 ENSMUST00000107970.3 ENSMUST00000107970.4 ENSMUST00000107970.5 ENSMUST00000107970.6 ENSMUST00000107970.7 Klk12 NM_001415883 uc291pbc.1 uc291pbc.2 serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity secretory granule uc291pbc.1 uc291pbc.2 
ENSMUST00000107972.8 Zfp175 ENSMUST00000107972.8 zinc finger protein 658 (from RefSeq NM_001008549.2) BC043301 ENSMUST00000107972.1 ENSMUST00000107972.2 ENSMUST00000107972.3 ENSMUST00000107972.4 ENSMUST00000107972.5 ENSMUST00000107972.6 ENSMUST00000107972.7 NM_001008549 Q5PPQ4 Q5PPQ4_MOUSE Zfp658 uc009gnb.1 uc009gnb.2 uc009gnb.3 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc009gnb.1 uc009gnb.2 uc009gnb.3 
ENSMUST00000107974.3 Iglon5 ENSMUST00000107974.3 IgLON family member 5 (from RefSeq NM_001164518.2) A7E1X9 ENSMUST00000107974.1 ENSMUST00000107974.2 IGLO5_MOUSE NM_001164518 Q8HW98 uc009gmv.1 uc009gmv.2 uc009gmv.3 uc009gmv.4 Secreted Belongs to the immunoglobulin superfamily. IgLON family. molecular_function extracellular region uc009gmv.1 uc009gmv.2 uc009gmv.3 uc009gmv.4 
ENSMUST00000107975.8 Phf24 ENSMUST00000107975.8 PHD finger protein 24, transcript variant 6 (from RefSeq NM_001374110.1) A2AG28 ENSMUST00000107975.1 ENSMUST00000107975.2 ENSMUST00000107975.3 ENSMUST00000107975.4 ENSMUST00000107975.5 ENSMUST00000107975.6 ENSMUST00000107975.7 Kiaa1045 N28178 NM_001374110 PHF24_MOUSE Phf24 Q80TL4 Q8BH08 uc008sol.1 uc008sol.2 uc008sol.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80TL4-1; Sequence=Displayed; Name=2; IsoId=Q80TL4-2; Sequence=VSP_014952; Sequence=BAC65710.1; Type=Erroneous initiation; Evidence=; protein binding cellular_component gamma-aminobutyric acid signaling pathway regulation of G-protein coupled receptor protein signaling pathway regulation of synaptic transmission, GABAergic metal ion binding detection of mechanical stimulus involved in sensory perception of pain uc008sol.1 uc008sol.2 uc008sol.3 
ENSMUST00000107978.2 Spata31f3 ENSMUST00000107978.2 spermatogenesis associated 31 subfamily F member 3, transcript variant 5 (from RefSeq NM_001425862.1) ENSMUST00000107978.1 Fam205c NM_001425862 Q80YD3 Q8C5W8 S31F3_MOUSE uc008soh.1 uc008soh.2 uc008soh.3 uc008soh.4 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80YD3-1; Sequence=Displayed; Name=2; IsoId=Q80YD3-2; Sequence=VSP_031342; Belongs to the SPATA31 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008soh.1 uc008soh.2 uc008soh.3 uc008soh.4 
ENSMUST00000107979.2 Spata31f1a ENSMUST00000107979.2 spermatogenesis associated 31 subfamily F member 1A (from RefSeq NM_001277167.1) D3YZF6 D3YZF6_MOUSE ENSMUST00000107979.1 Fam205a1 Gm12429 NM_001277167 Spata31f1a uc029uty.1 uc029uty.2 uc029uty.3 Membrane ; Single- pass membrane protein Belongs to the SPATA31 family. membrane integral component of membrane uc029uty.1 uc029uty.2 uc029uty.3 
ENSMUST00000107981.3 Spata31f1e ENSMUST00000107981.3 Membrane ; Single- pass membrane protein (from UniProt A2AKP6) A2AKP6 A2AKP6_MOUSE ENSMUST00000107981.1 ENSMUST00000107981.2 Gm12394 Spata31f1e uc008slw.1 uc008slw.2 uc008slw.3 uc008slw.4 Membrane ; Single- pass membrane protein Belongs to the SPATA31 family. molecular_function cellular_component biological_process uc008slw.1 uc008slw.2 uc008slw.3 uc008slw.4 
ENSMUST00000107985.10 Postn ENSMUST00000107985.10 periostin, osteoblast specific factor, transcript variant 4 (from RefSeq NM_001313898.1) ENSMUST00000107985.1 ENSMUST00000107985.2 ENSMUST00000107985.3 ENSMUST00000107985.4 ENSMUST00000107985.5 ENSMUST00000107985.6 ENSMUST00000107985.7 ENSMUST00000107985.8 ENSMUST00000107985.9 NM_001313898 Osf2 POSTN_MOUSE Q62009 Q8BMJ6 Q8K1K0 uc008pfi.1 uc008pfi.2 uc008pfi.3 uc008pfi.4 This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:10404027). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (PubMed:20181949). Homodimer (By similarity). Interacts with BMP1 and fibronectin (PubMed:20181949). Golgi apparatus Secreted Secreted, extracellular space, extracellular matrix Note=Colocalizes with BMP1 in the Golgi (PubMed:20181949). Event=Alternative splicing; Named isoforms=5; Name=1 ; IsoId=Q62009-1; Sequence=Displayed; Name=2 ; IsoId=Q62009-2; Sequence=VSP_050666; Name=3 ; IsoId=Q62009-3; Sequence=VSP_050668; Name=4 ; IsoId=Q62009-4; Sequence=VSP_050667; Name=5 ; IsoId=Q62009-5; Sequence=VSP_050666, VSP_050668; Preferentially expressed in periosteum and periodontal ligament (PubMed:10404027). Also expressed in the developing and adult heart (PubMed:11335131). In the heart, expressed from embryonic day 10.5. Continues to be strongly expressed throughout cardiac development and into adulthood (PubMed:11335131). By TGF-beta (PubMed:11335131). Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; these residues may be required for binding to calcium (PubMed:18450759). According to a more recent report in human, does not contain vitamin K-dependent gamma-carboxyglutamate residues (By similarity). Reduced amount of collagen cross-linking in femur and periosteum (PubMed:20181949). response to hypoxia negative regulation of cell-matrix adhesion regulation of systemic arterial blood pressure extracellular matrix structural constituent extracellular region extracellular space cytoplasm Golgi apparatus trans-Golgi network cell adhesion heparin binding regulation of Notch signaling pathway response to mechanical stimulus tissue development response to muscle activity positive regulation of smooth muscle cell migration extracellular matrix organization extracellular matrix neuromuscular junction response to estradiol wound healing cellular response to fibroblast growth factor stimulus metal ion binding cell adhesion molecule binding cellular response to vitamin K cellular response to tumor necrosis factor cellular response to transforming growth factor beta stimulus negative regulation of substrate adhesion-dependent cell spreading positive regulation of chemokine (C-C motif) ligand 2 secretion neuron projection extension bone regeneration uc008pfi.1 uc008pfi.2 uc008pfi.3 uc008pfi.4 
ENSMUST00000107986.9 Zfp715 ENSMUST00000107986.9 zinc finger protein 715, transcript variant 1 (from RefSeq NM_027264.4) ENSMUST00000107986.1 ENSMUST00000107986.2 ENSMUST00000107986.3 ENSMUST00000107986.4 ENSMUST00000107986.5 ENSMUST00000107986.6 ENSMUST00000107986.7 ENSMUST00000107986.8 G3X9T1 G3X9T1_MOUSE NM_027264 Zfp715 uc009gmj.1 uc009gmj.2 uc009gmj.3 negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding nucleoplasm cytosol regulation of transcription, DNA-templated intermediate filament cytoskeleton positive regulation of transcription from RNA polymerase II promoter metal ion binding uc009gmj.1 uc009gmj.2 uc009gmj.3 
ENSMUST00000107991.4 Gm3892 ENSMUST00000107991.4 Gm3892 (from geneSymbol) AK029949 ENSMUST00000107991.1 ENSMUST00000107991.2 ENSMUST00000107991.3 uc290mab.1 uc290mab.2 uc290mab.3 uc290mab.1 uc290mab.2 uc290mab.3 
ENSMUST00000107992.2 Zfp975 ENSMUST00000107992.2 zinc finger protein 975, transcript variant 2 (from RefSeq NM_001419398.1) EG434179 ENSMUST00000107992.1 Gm5595 NM_001419398 Q6NVD6 Q6NVD6_MOUSE Zfp975 uc009gme.1 uc009gme.2 uc009gme.3 transcription regulatory region sequence-specific DNA binding nucleic acid binding cellular_component nucleus regulation of transcription, DNA-templated metal ion binding uc009gme.1 uc009gme.2 uc009gme.3 
ENSMUST00000108014.2 Gm10985 ENSMUST00000108014.2 Gm10985 (from geneSymbol) ENSMUST00000108014.1 F6T1P1 F6T1P1_MOUSE Gm10985 uc290fgc.1 uc290fgc.2 molecular_function cellular_component biological_process membrane integral component of membrane uc290fgc.1 uc290fgc.2 
ENSMUST00000108015.4 Zfp619 ENSMUST00000108015.4 zinc finger protein 619 (from RefSeq NM_001004139.3) ENSMUST00000108015.1 ENSMUST00000108015.2 ENSMUST00000108015.3 G3X9T2 G3X9T2_MOUSE NM_001004139 Zfp619 uc009glc.1 uc009glc.2 uc009glc.3 nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc009glc.1 uc009glc.2 uc009glc.3 
ENSMUST00000108017.2 Gm5114 ENSMUST00000108017.2 predicted gene 5114 (from RefSeq NM_177890.3) ENSMUST00000108017.1 Gm5114 NM_177890 W4VSN8 W4VSN8_MOUSE uc009gkz.1 uc009gkz.2 molecular_function cellular_component biological_process uc009gkz.1 uc009gkz.2 
ENSMUST00000108022.8 Ptrh2 ENSMUST00000108022.8 peptidyl-tRNA hydrolase 2, transcript variant 2 (from RefSeq NM_001098810.3) ENSMUST00000108022.1 ENSMUST00000108022.2 ENSMUST00000108022.3 ENSMUST00000108022.4 ENSMUST00000108022.5 ENSMUST00000108022.6 ENSMUST00000108022.7 NM_001098810 PTH2_MOUSE Pth2 Q8BI01 Q8BI31 Q8R2Y8 uc007ksz.1 uc007ksz.2 uc007ksz.3 The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Reaction=an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L- amino acid + H(+); Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123, Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191; EC=3.1.1.29; Monomer. Mitochondrion outer membrane ; Single-pass membrane protein Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. Belongs to the PTH2 family. Sequence=BAC26006.1; Type=Erroneous initiation; Evidence=; aminoacyl-tRNA hydrolase activity mitochondrion cytosol negative regulation of gene expression hydrolase activity positive regulation of anoikis negative regulation of anoikis uc007ksz.1 uc007ksz.2 uc007ksz.3 
ENSMUST00000108023.10 Ccne1 ENSMUST00000108023.10 cyclin E1 (from RefSeq NM_007633.2) CCNE1_MOUSE Ccne ENSMUST00000108023.1 ENSMUST00000108023.2 ENSMUST00000108023.3 ENSMUST00000108023.4 ENSMUST00000108023.5 ENSMUST00000108023.6 ENSMUST00000108023.7 ENSMUST00000108023.8 ENSMUST00000108023.9 NM_007633 Q05BA1 Q05BA6 Q05BB7 Q61457 uc009gkr.1 uc009gkr.2 uc009gkr.3 Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation (By similarity). Found in a complex with CDK2, CABLES1 and CCNA1 (PubMed:11585773). Interacts with INCA1 (By similarity). Q61457; P11440: Cdk1; NbExp=3; IntAct=EBI-643090, EBI-846949; Q61457; P97377: Cdk2; NbExp=3; IntAct=EBI-643090, EBI-847048; Nucleus Found in adult spleen, and to a lesser extent in adult testis and brain. Phosphorylation of both Thr-393 by GSK3 and Ser-397 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-74 creates a low affinity degron also recognized by FBXW7 (By similarity). Ubiquitinated by UHRF2; appears to occur independently of phosphorylation. Belongs to the cyclin family. Cyclin E subfamily. Sequence=CAA53482.1; Type=Frameshift; Evidence=; regulation of cyclin-dependent protein serine/threonine kinase activity G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter cyclin-dependent protein kinase holoenzyme complex telomere maintenance protein binding nucleus nucleoplasm cytoplasm centrosome DNA replication initiation protein phosphorylation cell cycle synapsis Wnt signaling pathway kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding mitotic cell cycle phase transition macromolecular complex binding positive regulation of cell differentiation cell division regulation of cell cycle chromosome organization involved in meiotic cell cycle cyclin E1-CDK2 complex positive regulation of G1/S transition of mitotic cell cycle regulation of cellular protein localization protein kinase activity uc009gkr.1 uc009gkr.2 uc009gkr.3 
ENSMUST00000108026.3 Spata31f1d ENSMUST00000108026.3 spermatogenesis associated 31 subfamily F member 1D (from RefSeq NM_001357590.1) 31F14_MOUSE A2APU8 C0HKD3 ENSMUST00000108026.1 ENSMUST00000108026.2 Fam205a4 NM_001357590 Spata31f1-4 uc057lhm.1 uc057lhm.2 uc057lhm.3 Membrane ; Single-pass membrane protein Belongs to the SPATA31 family. membrane integral component of membrane uc057lhm.1 uc057lhm.2 uc057lhm.3 
ENSMUST00000108037.9 Ccl27a ENSMUST00000108037.9 C-C motif chemokine ligand 27A, transcript variant 6 (from RefSeq NR_154591.1) A2AMS7 A2AMS7_MOUSE Ccl27a ENSMUST00000108037.1 ENSMUST00000108037.2 ENSMUST00000108037.3 ENSMUST00000108037.4 ENSMUST00000108037.5 ENSMUST00000108037.6 ENSMUST00000108037.7 ENSMUST00000108037.8 NR_154591 uc008sjw.1 uc008sjw.2 uc008sjw.3 uc008sjw.4 uc008sjw.5 Secreted Belongs to the intercrine beta (chemokine CC) family. extracellular region immune response chemokine activity cell chemotaxis uc008sjw.1 uc008sjw.2 uc008sjw.3 uc008sjw.4 uc008sjw.5 
ENSMUST00000108041.8 Il11ra1 ENSMUST00000108041.8 Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. (from UniProt Q64385) A2AMS4 BC004619 ENSMUST00000108041.1 ENSMUST00000108041.2 ENSMUST00000108041.3 ENSMUST00000108041.4 ENSMUST00000108041.5 ENSMUST00000108041.6 ENSMUST00000108041.7 Etl2 I11RA_MOUSE Il11ra Il11ra1 Q64385 Q6NSQ0 uc290lye.1 uc290lye.2 Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. [Soluble interleukin-11 receptor subunit alpha]: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling. On IL11 binding, forms a multimer complex with IL6ST/gp130. [Interleukin-11 receptor subunit alpha-1]: Membrane ; Single-pass type I membrane protein Secreted [Soluble interleukin-11 receptor subunit alpha]: Secreted Widely expressed in all adult tissues and in embryos. Highest levels in kidney, skeletal muscle and embryo. First detected at low levels at 10.5 dpc in cranofacial mesenchyme and in parts of the nervous system. At 12.5 dpc, high expression found in heart, diaphragm, bronchi and in the mesenchyme surrounding precartilage condensations. At later stages, expressed in dental papilla, dermis, hair follicles and in the perichondrium and in regions containing chondro and osteo progenitor cells. A short soluble form is also released from the membrane by proteolysis (PubMed:26876177). The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing (PubMed:26876177). mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3 (PubMed:26876177). Mice have disturbed cranial growth and suture activity. Belongs to the type I cytokine receptor family. Type 3 subfamily. natural killer cell differentiation placenta development cytokine receptor activity interleukin-11 receptor activity positive regulation of cell proliferation external side of plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway cytokine binding interleukin-11 binding developmental process interleukin-11-mediated signaling pathway receptor complex decidualization maternal process involved in female pregnancy head development uc290lye.1 uc290lye.2 
ENSMUST00000108044.4 Il18r1 ENSMUST00000108044.4 interleukin 18 receptor 1, transcript variant 1 (from RefSeq NM_008365.2) ENSMUST00000108044.1 ENSMUST00000108044.2 ENSMUST00000108044.3 IL18R_MOUSE Il18r1 NM_008365 Q61098 uc011wjz.1 uc011wjz.2 Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (PubMed:26099046). Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302; Evidence=; Forms a ternary complex with IL18 and IL18RAP (By similarity). Within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (By similarity). Interacts with SLC12A3 in peritoneal macrophages; this interaction is increased by IL18 treatment (PubMed:26099046). Q61098; P59158: Slc12a3; NbExp=5; IntAct=EBI-13612516, EBI-8366645; Membrane ; Single- pass type I membrane protein The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. Belongs to the interleukin-1 receptor family. protein binding inflammatory response signal transduction membrane integral component of membrane natural killer cell activation positive regulation of interferon-gamma production interleukin-18-mediated signaling pathway interleukin-18 binding interleukin-18 receptor activity T-helper 1 cell differentiation interleukin-18 receptor complex positive regulation of NF-kappaB transcription factor activity positive regulation of NIK/NF-kappaB signaling positive regulation of T-helper 1 cell cytokine production uc011wjz.1 uc011wjz.2 
ENSMUST00000108047.8 Tbx4 ENSMUST00000108047.8 T-box 4, transcript variant 1 (from RefSeq NM_011536.3) B1AQT9 ENSMUST00000108047.1 ENSMUST00000108047.2 ENSMUST00000108047.3 ENSMUST00000108047.4 ENSMUST00000108047.5 ENSMUST00000108047.6 ENSMUST00000108047.7 NM_011536 P70325 Q8R5F6 TBX4_MOUSE uc288bbm.1 uc288bbm.2 Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs. Nucleus First expressed at day 7.5, exclusively in the allantois where expression continues through day 8.5. At day 9.5, expression is found in the genital papilla, body wall and limb buds (higher levels in hindlimb). At day 12.5, expressed in the mesenchyme of the mandibular arch, of the lung and of that surrounding the trachea. Also found in the sinus venosus/common atrium of the developing heart. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis cell fate specification morphogenesis of an epithelium DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated multicellular organism development lung development embryonic limb morphogenesis limb morphogenesis positive regulation of transcription from RNA polymerase II promoter skeletal system morphogenesis uc288bbm.1 uc288bbm.2 
ENSMUST00000108052.10 Fam219a ENSMUST00000108052.10 family with sequence similarity 219, member A, transcript variant 9 (from RefSeq NR_165082.1) 2310028H24Rik A2ANP1 A2ANP1_MOUSE ENSMUST00000108052.1 ENSMUST00000108052.2 ENSMUST00000108052.3 ENSMUST00000108052.4 ENSMUST00000108052.5 ENSMUST00000108052.6 ENSMUST00000108052.7 ENSMUST00000108052.8 ENSMUST00000108052.9 Fam219a NR_165082 uc008sja.1 uc008sja.2 uc008sja.3 Belongs to the FAM219 family. uc008sja.1 uc008sja.2 uc008sja.3 
ENSMUST00000108055.9 Kif24 ENSMUST00000108055.9 kinesin family member 24 (from RefSeq NM_024241.2) A2BGK6 ENSMUST00000108055.1 ENSMUST00000108055.2 ENSMUST00000108055.3 ENSMUST00000108055.4 ENSMUST00000108055.5 ENSMUST00000108055.6 ENSMUST00000108055.7 ENSMUST00000108055.8 KIF24_MOUSE NM_024241 Q6NWW5 Q8BUI2 Q99PT7 uc008sio.1 uc008sio.2 uc008sio.3 Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (By similarity). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (By similarity). Interacts with CCP110, CEP97, TALPID3 (By similarity). Interacts with MPHOSPH9 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NWW5-1; Sequence=Displayed; Name=2; IsoId=Q6NWW5-2; Sequence=VSP_023214; Expressed in brain, spinal cord, and small intestine. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Sequence=AAH67395.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC39323.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; nucleotide binding microtubule motor activity ATP binding cytoplasm centriole cytoskeleton kinesin complex microtubule microtubule-based movement microtubule depolymerization microtubule binding ATPase activity cell projection organization macromolecular complex identical protein binding cilium assembly uc008sio.1 uc008sio.2 uc008sio.3 
ENSMUST00000108074.8 Garre1 ENSMUST00000108074.8 granule associated Rac and RHOG effector 1, transcript variant 2 (from RefSeq NM_172741.3) 4931406P16Rik ENSMUST00000108074.1 ENSMUST00000108074.2 ENSMUST00000108074.3 ENSMUST00000108074.4 ENSMUST00000108074.5 ENSMUST00000108074.6 ENSMUST00000108074.7 Garre1 NM_172741 Q8C5X1 Q8C5X1_MOUSE uc009giz.1 uc009giz.2 uc009giz.3 molecular_function cellular_component biological_process uc009giz.1 uc009giz.2 uc009giz.3 
ENSMUST00000108075.9 Usp32 ENSMUST00000108075.9 ubiquitin specific peptidase 32 (from RefSeq NM_001029934.1) ENSMUST00000108075.1 ENSMUST00000108075.2 ENSMUST00000108075.3 ENSMUST00000108075.4 ENSMUST00000108075.5 ENSMUST00000108075.6 ENSMUST00000108075.7 ENSMUST00000108075.8 F8VPZ3 NM_001029934 Q3US74 Q6PD17 Q7TT84 Q8CCP4 UBP32_MOUSE Usp32 uc007krh.1 uc007krh.2 uc007krh.3 Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (By similarity). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Golgi apparatus membrane ; Lipid-anchor Belongs to the peptidase C19 family. thiol-dependent ubiquitin-specific protease activity calcium ion binding Golgi apparatus cytosol ubiquitin-dependent protein catabolic process protein deubiquitination thiol-dependent ubiquitinyl hydrolase activity uc007krh.1 uc007krh.2 uc007krh.3 
ENSMUST00000108078.9 Abhd18 ENSMUST00000108078.9 Secreted (from UniProt Q8C1A9) ABD18_MOUSE AK169375 Abhd18 ENSMUST00000108078.1 ENSMUST00000108078.2 ENSMUST00000108078.3 ENSMUST00000108078.4 ENSMUST00000108078.5 ENSMUST00000108078.6 ENSMUST00000108078.7 ENSMUST00000108078.8 Q3TQS7 Q562E0 Q8C0I3 Q8C1A9 uc290evy.1 uc290evy.2 Secreted Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C1A9-1; Sequence=Displayed; Name=2; IsoId=Q8C1A9-2; Sequence=VSP_027896; Name=3; IsoId=Q8C1A9-3; Sequence=VSP_027895; Belongs to the AB hydrolase superfamily. molecular_function cellular_component extracellular region biological_process uc290evy.1 uc290evy.2 
ENSMUST00000108081.9 Ggnbp2 ENSMUST00000108081.9 gametogenetin binding protein 2, transcript variant 3 (from RefSeq NM_153144.3) A4QPD5 B7ZP33 ENSMUST00000108081.1 ENSMUST00000108081.2 ENSMUST00000108081.3 ENSMUST00000108081.4 ENSMUST00000108081.5 ENSMUST00000108081.6 ENSMUST00000108081.7 ENSMUST00000108081.8 GGNB2_MOUSE NM_153144 Q5SV75 Q5SV76 Q5SV77 Q5SV78 Q6GVH6 Q6P9J4 Q920N4 Zfp403 Znf403 uc288aze.1 uc288aze.2 May be involved in spermatogenesis. Interacts with isoform 1 of GGN. Q5SV77; Q80WJ1: Ggn; NbExp=3; IntAct=EBI-4370069, EBI-3890505; Cytoplasmic vesicle Note=Associated with vesicular structures. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5SV77-1; Sequence=Displayed; Name=2; IsoId=Q5SV77-2; Sequence=VSP_019180; Name=3; IsoId=Q5SV77-3; Sequence=VSP_019179, VSP_019180; Name=4; IsoId=Q5SV77-4; Sequence=VSP_019179; Testis-specific. Abundantly expressed during spermatogenesis. Not detected in newborn animals, in which spermatogenesis has not yet progressed beyond the earliest stages. By dioxin (2,3,7,8-Tetrachlorodibenzo-p-dioxin). Sequence=AAH60738.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=CAI24983.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAI25484.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAI25487.1; Type=Erroneous gene model prediction; Evidence=; protein binding nucleus cytoplasm multicellular organism development spermatogenesis negative regulation of cell proliferation negative regulation of gene expression cell differentiation cytoplasmic vesicle negative regulation of peptidyl-serine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein labyrinthine layer development labyrinthine layer blood vessel development negative regulation of protein tyrosine kinase activity uc288aze.1 uc288aze.2 
ENSMUST00000108083.2 Scgb1b30 ENSMUST00000108083.2 secretoglobin, family 1B, member 30 (from RefSeq NM_001099330.2) A2BH64 A2BH64_MOUSE ENSMUST00000108083.1 NM_001099330 Scgb1b30 uc009gir.1 uc009gir.2 Secreted steroid binding extracellular region biological_process uc009gir.1 uc009gir.2 
ENSMUST00000108087.4 Scgb1b24 ENSMUST00000108087.4 secretoglobin, family 1B, member 24 (from RefSeq NM_001099329.3) Abpa24 B1B0N6 B1B0N6_MOUSE ENSMUST00000108087.1 ENSMUST00000108087.2 ENSMUST00000108087.3 Gm12769 NM_001099329 Scgb1b24 uc009gin.1 uc009gin.2 uc009gin.3 uc009gin.4 Secreted steroid binding extracellular region biological_process uc009gin.1 uc009gin.2 uc009gin.3 uc009gin.4 
ENSMUST00000108090.3 Scgb2b3 ENSMUST00000108090.3 secretoglobin, family 2B, member 3 (from RefSeq NM_001270541.2) Abpbg3 D2XZ38 D2XZ38_MOUSE ENSMUST00000108090.1 ENSMUST00000108090.2 Gm4362 NM_001270541 Scgb2b3 uc033iyo.1 uc033iyo.2 Secreted Belongs to the secretoglobin family. molecular_function cellular_component extracellular space biological_process uc033iyo.1 uc033iyo.2 
ENSMUST00000108094.5 Scgb1b29 ENSMUST00000108094.5 secretoglobin, family 1B, member 29 (from RefSeq NM_001256066.1) Abpa29 Abpa29_a7 Abpa7 D2XZ31 D2XZ31_MOUSE ENSMUST00000108094.1 ENSMUST00000108094.2 ENSMUST00000108094.3 ENSMUST00000108094.4 NM_001256066 Scgb1b29 Scgb1b7 uc012fic.1 uc012fic.2 uc012fic.3 uc012fic.4 Secreted steroid binding extracellular region biological_process uc012fic.1 uc012fic.2 uc012fic.3 uc012fic.4 
ENSMUST00000108097.4 Scgb1b7 ENSMUST00000108097.4 secretoglobin, family 1B, member 7 (from RefSeq NM_001270542.1) Abpa29 Abpa29_a7 Abpa7 D2XZ31 D2XZ31_MOUSE ENSMUST00000108097.1 ENSMUST00000108097.2 ENSMUST00000108097.3 NM_001270542 Scgb1b29 Scgb1b7 uc012fib.1 uc012fib.2 uc012fib.3 uc012fib.4 Secreted steroid binding extracellular region biological_process uc012fib.1 uc012fib.2 uc012fib.3 uc012fib.4 
ENSMUST00000108109.8 Spry1 ENSMUST00000108109.8 sprouty RTK signaling antagonist 1, transcript variant 4 (from RefSeq NM_001305442.1) ENSMUST00000108109.1 ENSMUST00000108109.2 ENSMUST00000108109.3 ENSMUST00000108109.4 ENSMUST00000108109.5 ENSMUST00000108109.6 ENSMUST00000108109.7 NM_001305442 Q9QXV9 SPY1_MOUSE uc008pax.1 uc008pax.2 uc008pax.3 uc008pax.4 Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (PubMed:25576668). Forms heterodimers with SPRY2 (PubMed:16877379). Interacts with TESK1 (PubMed:17974561). Interacts with CAV1 (via C-terminus) (PubMed:16877379). Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). At 8.5 dpc, expressed in the primitive streak, rostral forebrain, cells lateral to the posterior hindbrain, anterior hindbrain and developing midbrain (PubMed:10498682). At 9.5 dpc, continues to be expressed in the rostral forebrain and primitive streak, and is also detected in the branchial arches and the forelimb bud (PubMed:10498682). At 10.5 dpc, expressed in the somites, frontonasal processes, tailbud, and hindlimb bud (PubMed:10498682). The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles. Belongs to the sprouty family. establishment of mitotic spindle orientation metanephros development ureteric bud development organ induction protein binding nucleoplasm cytoplasm Golgi apparatus cytosol multicellular organism development negative regulation of cell proliferation regulation of signal transduction membrane negative regulation of GTPase activity negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of MAP kinase activity negative regulation of Ras protein signal transduction negative regulation of neurotrophin TRK receptor signaling pathway bud elongation involved in lung branching epithelial to mesenchymal transition involved in cardiac fibroblast development negative regulation of ERK1 and ERK2 cascade uc008pax.1 uc008pax.2 uc008pax.3 uc008pax.4 
ENSMUST00000108114.9 Hnf1b ENSMUST00000108114.9 HNF1 homeobox B, transcript variant 2 (from RefSeq NM_001291268.1) ENSMUST00000108114.1 ENSMUST00000108114.2 ENSMUST00000108114.3 ENSMUST00000108114.4 ENSMUST00000108114.5 ENSMUST00000108114.6 ENSMUST00000108114.7 ENSMUST00000108114.8 HNF1B_MOUSE Hnf-1b NM_001291268 P27889 Q5NC37 Q8R162 Q9CS26 Q9R1W1 Q9R1W2 Q9WTL5 Q9WTL6 Tcf2 uc007kpy.1 uc007kpy.2 uc007kpy.3 uc007kpy.4 Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (By similarity). Binds DNA as a dimer. Can form homodimer or heterodimer with HNF1-alpha (By similarity). Interacts (via HNF-p1 domain) with PCBD1; the interaction increases its transactivation activity (By similarity). Nucleus. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P27889-1; Sequence=Displayed; Name=2; IsoId=P27889-2; Sequence=VSP_007100; Name=3; IsoId=P27889-3; Sequence=VSP_007099; Name=4; IsoId=P27889-4; Sequence=VSP_007099, VSP_007100; Belongs to the HNF1 homeobox family. Sequence=BAB31632.2; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding endoderm formation endodermal cell fate specification kidney development inner cell mass cell differentiation liver development DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex regulation of transcription from RNA polymerase II promoter Notch signaling pathway endoderm development response to carbohydrate response to glucose anterior/posterior pattern specification positive regulation of gene expression response to organic cyclic compound insulin secretion regulation of Wnt signaling pathway hindbrain development pancreas development endocrine pancreas development circadian regulation of gene expression regulation of pronephros size pronephric nephron tubule development response to drug protein homodimerization activity negative regulation of apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding macromolecular complex binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity embryonic digestive tract morphogenesis embryonic morphogenesis branching morphogenesis of an epithelial tube pronephros development genitalia development epithelial cell proliferation positive regulation of transcription initiation from RNA polymerase II promoter epithelium development ureteric bud elongation kidney morphogenesis hepatoblast differentiation negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis protein-DNA complex assembly hepatocyte differentiation regulation of branch elongation involved in ureteric bud branching mesonephric tubule development nephric duct development mesonephric duct development nephric duct formation mesonephric duct formation negative regulation of mesenchymal cell apoptotic process involved in metanephros development uc007kpy.1 uc007kpy.2 uc007kpy.3 uc007kpy.4 
ENSMUST00000108116.10 Lsr ENSMUST00000108116.10 lipolysis stimulated lipoprotein receptor, transcript variant 2 (from RefSeq NM_001164184.1) ENSMUST00000108116.1 ENSMUST00000108116.2 ENSMUST00000108116.3 ENSMUST00000108116.4 ENSMUST00000108116.5 ENSMUST00000108116.6 ENSMUST00000108116.7 ENSMUST00000108116.8 ENSMUST00000108116.9 Ildr3 LSR_MOUSE Lisch7 Lsr NM_001164184 Q3TJE7 Q3UIQ9 Q61148 Q61149 Q6U816 Q99KG5 uc009ghk.1 uc009ghk.2 uc009ghk.3 uc009ghk.4 Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (PubMed:15265030). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (PubMed:21245199, PubMed:23239027). Homotrimer or homotetramer (By similarity). Assembles into cell-cell contacts (PubMed:21245199). Interacts (via the cytoplasmic domain) with MARVELD2 (via C-terminal cytoplasmic domain); the interaction is required to recruit MARVELD2 to tricellular contacts (PubMed:21245199, PubMed:23239027). Interacts with OCLN (PubMed:23239027). Cell membrane ; Single-pass type I membrane protein Cell junction, tight junction te=Located at tricellular contacts. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99KG5-1; Sequence=Displayed; Name=2; IsoId=Q99KG5-2; Sequence=VSP_019696; Name=3; IsoId=Q99KG5-3; Sequence=VSP_019695; Expressed in eptihelial tissues (at protein level) (PubMed:21245199). Specifically expressed in liver and to a lower extent in kidney (at protein level). Also detected in brain, testis, ovaries, adrenal gland, intestine, muscle, and lung. In colon, only expressed in the lower portion of crypts (PubMed:23239027). Expressed in the liver. [Isoform 2]: Expressed in liver, stomach, small intestine and colon. Also detected in other epithelial tissues. Expressed during embryogenesis (at protein level). Detected from 7.5 dpc to 17 dpc. Phosphorylation at Ser-308 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions. Death between 12.5 dpc and 15.5 dpc probably due to impaired liver and embryonic development. Belongs to the immunoglobulin superfamily. LISCH7 family. Sequence=AAA92719.1; Type=Frameshift; Evidence=; liver development protein binding plasma membrane endocytosis membrane integral component of membrane regulation of lipid metabolic process low-density lipoprotein particle binding lipoprotein particle receptor activity very-low-density lipoprotein particle low-density lipoprotein particle chylomicron lipoprotein transport establishment of blood-brain barrier establishment of skin barrier tricellular tight junction tricellular tight junction assembly uc009ghk.1 uc009ghk.2 uc009ghk.3 uc009ghk.4 
ENSMUST00000108122.8 Lingo2 ENSMUST00000108122.8 leucine rich repeat and Ig domain containing 2, transcript variant 2 (from RefSeq NM_001166000.1) ENSMUST00000108122.1 ENSMUST00000108122.2 ENSMUST00000108122.3 ENSMUST00000108122.4 ENSMUST00000108122.5 ENSMUST00000108122.6 ENSMUST00000108122.7 LIGO2_MOUSE Lrrn6c NM_001166000 Q3URE9 Q8BLC0 Q8BZD4 uc008shb.1 uc008shb.2 uc008shb.3 uc008shb.4 uc008shb.5 Membrane ; Single-pass type I membrane protein molecular_function extracellular space membrane integral component of membrane extracellular matrix positive regulation of synapse assembly uc008shb.1 uc008shb.2 uc008shb.3 uc008shb.4 uc008shb.5 
ENSMUST00000108127.4 C9orf72 ENSMUST00000108127.4 C9orf72, member of C9orf72-SMCR8 complex, transcript variant 1 (from RefSeq NM_001081343.2) A6PWW3 C9orf72 CI072_MOUSE Dennd9 Dennl72 ENSMUST00000108127.1 ENSMUST00000108127.2 ENSMUST00000108127.3 NM_001081343 Q3TJP2 Q3U3D8 Q6DFW0 uc008sgv.1 uc008sgv.2 uc008sgv.3 Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27617292). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (By similarity). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and modulating its protein kinase activity (PubMed:27193190, PubMed:27617292). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (By similarity). Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ULK1/ATG1 kinase complex to the phagophore which leads to autophagosome formation (By similarity). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27875531). Plays a role in endosomal trafficking (PubMed:26989253). May be involved in regulating the maturation of phagosomes to lysosomes (PubMed:26989253). Promotes the lysosomal localization and lysosome-mediated degradation of CARM1 which leads to inhibition of starvation-induced lipid metabolism (PubMed:30366907). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of CFL1/cofilin, leading to cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Required for SMCR8 protein expression and localization at pre- and post-synaptic compartments in the forebrain, also regulates protein abundance of RAB3A and GRIA1/GLUR1 in post-synaptic compartments in the forebrain and hippocampus (PubMed:31651360). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (PubMed:27412785). Component of the C9orf72-SMCR8 complex, at least composed of C9orf72, SMCR8 and WDR41 (Probable). The complex is formed of two protomers, each individually consisting of one molecule each of C9orf72, SMCR8 and WDR41 (By similarity). The protomers homodimerize via an interaction between C9orf72 (via C-terminus) and SMCR8 (via N- terminus) (By similarity). Within each protomer SMCR8 (via DENN domain) acts as a bridging protein between WDR41 (via C-terminus and N- terminus) and C9orf72 (via C-terminus) (By similarity). The C9orf72- SMCR8 complex associates with the ULK1/ATG1 kinase complex (By similarity). Interacts with ULK1/ATG1 kinase complex members ULK1, ATG13 and RB1CC1 (By similarity). Interacts with SMCR8; the interaction is direct (PubMed:27875531). Interacts with HNRNPA1, HNRNPA2B1 and UBQLN2 (By similarity). Interacts with small Rab GTPase RAB1A; the interaction mediates recruitment of RAB1A to the ULK1/ATG1 kinase complex (PubMed:24549040). Also interacts with small Rab GTPase RAB7A (PubMed:24549040). Interacts with cofilin (PubMed:27723745). Interacts with GTP-binding proteins ARF1 and ARF6 (PubMed:27723745). Interacts with the DLG4/PSD-95 (PubMed:31651360). Interacts with CARM1 (via PH domain-like fold) (PubMed:30366907). Nucleus toplasm toplasm, P-body Cytoplasm, Stress granule Endosome Lysosome Cytoplasmic vesicle, autophagosome Secreted Cell projection, axon Cell projection, growth cone Perikaryon Note=Detected in the cytoplasm of neurons from brain tissue (By similarity). Detected in the nucleus in fibroblasts (By similarity). Associates with cytoplasmic stress granules following cellular stress (By similarity). During corticogenesis, transitions from being predominantly cytoplasmic to a more even nucleocytoplasmic distribution (PubMed:27476503). [Isoform 1]: Perikaryon Cell projection, dendrite Presynapse Postsynapse Note=Expressed diffusely throughout the cytoplasm and dendritic processes of cerebellar Purkinje cells. Also expressed diffusely throughout the cytoplasm of spinal motor neurons. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6DFW0-1; Sequence=Displayed; Name=2; IsoId=Q6DFW0-2; Sequence=VSP_059260; Expressed in postnatal cerebellum and cortex (at protein level). Neuronal expression is detected in several regions of the adult brain and spinal cord (PubMed:26044557). Prominent expression also observed in embryonic and early postnatal neurons including retinal ganglion cells, sensory neurons in the olfactory epithelium and in dorsal root ganglia, and spinal motor neurons (PubMed:26044557). Expressed in the developing cerebral cortex, cerebellum, olfactory bulb, hippocampus and spinal cord in the embryo and in P0 cortical neurons and astrocytes (PubMed:27476503). Also expressed in non- neuronal tissues such as kidney and tooth (PubMed:26044557). In the spleen, highly expressed in myeloid cells compared to B cell and T cell populations where expression is much lower (PubMed:26989253). In the brain, highly expressed in microglia (PubMed:26989253). [Isoform 1]: Expressed in the forebrain, including in the glomerular layer of the olfactory bulb (at protein level). Expressed in cerebral cortex and hippocampus at embryonic day 18 and postnatal days 1, 7, 14, 28 and 56. Decreased life span (PubMed:27875531, PubMed:27412785). However, another report did not observe any effect on life span (PubMed:26989253). Lymph node and spleen enlargement phenotype accompanied by macrophage infiltration (PubMed:27193190, PubMed:27875531, PubMed:26989253, PubMed:27412785). Severe inflammation also observed in liver (PubMed:27193190, PubMed:27412785). Increased total white blood cell count due to a significant increase in the number of circulating neutrophils (PubMed:27412785). Significantly reduced platelet and red blood cell count (PubMed:27412785). Increased levels of autophagy and lysosomal proteins and autophagy defects in the spleen and liver (PubMed:27193190). Impaired activation of MTOR/mTOR (PubMed:27875531). Massive up-regulation of the cell surface receptor Trem2 (PubMed:26989253). Significantly increased levels of a number of inflammatory chemokines and cytokines (PubMed:26989253, PubMed:27412785). Increased levels of autoantibodies indicative of an autoimmune phenotype (PubMed:27412785). Normal weight gain, sensorimotor coordination, limb strength, femoral motor and sensory axon counts, and muscle electrophysiology (PubMed:26989253). Conditional knockout in neurons and glial cells results in significantly reduced body weight but does not induce motor neuron degeneration, defects in motor function or altered survival (PubMed:26044557). SMCR8 protein expression is abolished in pre- and post-synaptic compartments in forebrain synapses (PubMed:31651360). RAB3A expression levels are increased in synaptosomes, however are decreased in post-synaptic compartments of the forebrain and in the hippocampus (PubMed:31651360). GRIA1/GLUR1 protein levels are increased in forebrain post-synaptic compartments and in the hippocampus (PubMed:31651360). P-body negative regulation of protein phosphorylation guanyl-nucleotide exchange factor activity protein binding extracellular region extracellular space nucleus cytoplasm lysosome endosome autophagosome endocytosis autophagy cytoplasmic stress granule regulation of autophagy positive regulation of macroautophagy Rab guanyl-nucleotide exchange factor activity Rab GTPase binding axon dendrite growth cone cytoplasmic vesicle nuclear membrane guanyl-nucleotide exchange factor complex stress granule assembly cell projection neuron projection perikaryon axonal growth cone main axon axon extension late endosome to lysosome transport regulation of TORC1 signaling negative regulation of GTP binding ATG1/ULK1 kinase complex regulation of autophagosome assembly uc008sgv.1 uc008sgv.2 uc008sgv.3 
ENSMUST00000108137.9 Mmp28 ENSMUST00000108137.9 matrix metallopeptidase 28 (epilysin), transcript variant 3 (from RefSeq NM_001320300.1) ENSMUST00000108137.1 ENSMUST00000108137.2 ENSMUST00000108137.3 ENSMUST00000108137.4 ENSMUST00000108137.5 ENSMUST00000108137.6 ENSMUST00000108137.7 ENSMUST00000108137.8 Mmp28 NM_001320300 Q8CGV8 Q8CGV8_MOUSE uc007kpc.1 uc007kpc.2 uc007kpc.3 uc007kpc.4 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Can bind about 5 Ca(2+) ions per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. Belongs to the peptidase M10A family. metalloendopeptidase activity extracellular space cytoplasm proteolysis peptidase activity metallopeptidase activity zinc ion binding negative regulation of macrophage chemotaxis hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix metal ion binding uc007kpc.1 uc007kpc.2 uc007kpc.3 uc007kpc.4 
ENSMUST00000108140.10 Rasl10b ENSMUST00000108140.10 RAS-like, family 10, member B, transcript variant 4 (from RefSeq NM_001361568.1) ENSMUST00000108140.1 ENSMUST00000108140.2 ENSMUST00000108140.3 ENSMUST00000108140.4 ENSMUST00000108140.5 ENSMUST00000108140.6 ENSMUST00000108140.7 ENSMUST00000108140.8 ENSMUST00000108140.9 NM_001361568 Q5SSG5 RSLAB_MOUSE uc288awq.1 uc288awq.2 May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Interacts with CADPS. Cell membrane ; Lipid-anchor ; Cytoplasmic side Expressed in heart and brain. In the brain, expression restricted to neurons of the cortex, hippocampus and cerebellum. Sparse expression in the brainstem and almost absent in the hypothalamic region. In the heart, expressed in cardiomyocytes. Not detected in interstitial tissue or vascular cells. At 9.5 dpc, detected in the developing heart, skeletal myotomes and dorsal portion of the neural tube. At 13.5 and 15.5 dpc, expressed in the heart and neural tissue including the central and peripheral nervous system. In the embryonic brain, expression is restricted to more mature neurons and absent from the progenitor neuronal cells of the ventricular zone. Also present in mature peripheral neurons, such as the neurons of the dorsal root ganglia and the Auerbach's and Meissner's plexi of the intestinal tract. No obvious phenotype. Mutant mice are viable and fertile. Belongs to the small GTPase superfamily. Ras family. nucleotide binding regulation of systemic arterial blood pressure by atrial natriuretic peptide GTPase activity protein binding GTP binding cellular_component plasma membrane membrane positive regulation of peptide hormone secretion uc288awq.1 uc288awq.2 
ENSMUST00000108147.3 Etv2 ENSMUST00000108147.3 ets variant 2 (from RefSeq NM_007959.2) ENSMUST00000108147.1 ENSMUST00000108147.2 ETV2_MOUSE Er71 Etsrp71 F8VQ08 NM_007959 P41163 uc009gfm.1 uc009gfm.2 Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. Nucleus. Testis. Belongs to the ETS family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development mesoderm formation blastocyst development placenta development DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Notch signaling pathway positive regulation of gene expression Wnt signaling pathway hemopoiesis cell differentiation erythrocyte differentiation sequence-specific DNA binding positive regulation of endothelial cell differentiation positive regulation of transcription from RNA polymerase II promoter blood vessel morphogenesis BMP signaling pathway involved in mesodermal cell fate specification positive regulation of mesoderm development uc009gfm.1 uc009gfm.2 
ENSMUST00000108151.3 Zbtb32 ENSMUST00000108151.3 zinc finger and BTB domain containing 32, transcript variant 1 (from RefSeq NM_021397.2) B2RQ06 B2RQ06_MOUSE ENSMUST00000108151.1 ENSMUST00000108151.2 NM_021397 Zbtb32 uc009gfh.1 uc009gfh.2 nucleic acid binding uc009gfh.1 uc009gfh.2 
ENSMUST00000108153.9 Rngtt ENSMUST00000108153.9 RNA guanylyltransferase and 5'-phosphatase, transcript variant 1 (from RefSeq NM_011884.4) ENSMUST00000108153.1 ENSMUST00000108153.2 ENSMUST00000108153.3 ENSMUST00000108153.4 ENSMUST00000108153.5 ENSMUST00000108153.6 ENSMUST00000108153.7 ENSMUST00000108153.8 NM_011884 Q3UA94 Q3UA94_MOUSE Rngtt uc008sfv.1 uc008sfv.2 uc008sfv.3 Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate. Reaction=a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'- end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate; Xref=Rhea:RHEA:67012, Rhea:RHEA-COMP:17165, Rhea:RHEA-COMP:17166, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:167616, ChEBI:CHEBI:167617; EC=2.7.7.50; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67013; Evidence=; Reaction=a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate; Xref=Rhea:RHEA:67004, Rhea:RHEA-COMP:17164, Rhea:RHEA-COMP:17165, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:167616, ChEBI:CHEBI:167618; EC=3.6.1.74; Evidence=; Nucleus In the C-terminal section; belongs to the eukaryotic GTase family. In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family. nucleotide binding mRNA guanylyltransferase activity polynucleotide 5'-phosphatase activity protein tyrosine phosphatase activity GTP binding nucleus 7-methylguanosine mRNA capping RNA processing mRNA processing protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity RNA guanylyltransferase activity dephosphorylation transferase activity nucleotidyltransferase activity hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation triphosphatase activity polynucleotide 5' dephosphorylation uc008sfv.1 uc008sfv.2 uc008sfv.3 
ENSMUST00000108154.9 Kmt2b ENSMUST00000108154.9 lysine (K)-specific methyltransferase 2B, transcript variant 2 (from RefSeq NM_029274.2) E9QKF4 ENSMUST00000108154.1 ENSMUST00000108154.2 ENSMUST00000108154.3 ENSMUST00000108154.4 ENSMUST00000108154.5 ENSMUST00000108154.6 ENSMUST00000108154.7 ENSMUST00000108154.8 KMT2B_MOUSE Mll2 NM_029274 O08550 Q5NU09 Trx2 Wbp7 uc009gfg.1 uc009gfg.2 uc009gfg.3 Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (By similarity). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (By similarity). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (PubMed:20808952). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (PubMed:20808952). Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265; Evidence=; Reaction=N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60268, Rhea:RHEA-COMP:15540, Rhea:RHEA- COMP:15543, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60269; Evidence=; Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4, ASH2L, RBBP5, WDR5, DPY30, MEN1; the complex interacts with POLR2A and POLR2B via MEN1 (By similarity). Interacts with NFE2 (By similarity). Interacts with KDM6B (By similarity). Interacts (via WIN motif) with WDR5 (By similarity). Interacts (via MBM motif) with MEN1 (By similarity). Nucleus The CXXC zinc finger mediates binding to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Females are infertile due to anovulation and follicle loss. Oocytes show reduced H3K4me3 but not H3K4me1, abnormal expression of pro-apoptotic genes and Iap elements (which may contribute to oocyte death and, ultimately, follicle loss) and fail to establish transcriptional repression. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. The human ortholog, KMT2B/MLL4, was first named MLL2 (see AC Q9UMN6). Thus, mouse Kmt2b/Mll4 is also often referred to as Mll2 and vice versa in the literature. Sequence=AAC53192.1; Type=Miscellaneous discrepancy; Note=Possible contaminating sequence. The N-terminal 3 residues and C-terminal 8 residues do not match the underlying genomic sequence.; Evidence=; ovarian follicle development DNA binding nucleus chromatin organization regulation of transcription, DNA-templated memory methyltransferase activity zinc ion binding oocyte differentiation gene silencing transferase activity histone-lysine N-methyltransferase activity ovulation methylation histone lysine methylation histone methyltransferase complex histone methyltransferase activity (H3-K4 specific) positive regulation of transcription, DNA-templated metal ion binding histone H3-K4 methylation regulation of histone H3-K4 methylation histone H3-K4 trimethylation uc009gfg.1 uc009gfg.2 uc009gfg.3 
ENSMUST00000108156.9 Bbs7 ENSMUST00000108156.9 Bardet-Biedl syndrome 7 (from RefSeq NM_027810.3) BBS7_MOUSE Bbs2l1 ENSMUST00000108156.1 ENSMUST00000108156.2 ENSMUST00000108156.3 ENSMUST00000108156.4 ENSMUST00000108156.5 ENSMUST00000108156.6 ENSMUST00000108156.7 ENSMUST00000108156.8 NM_027810 Q8C7G3 Q8CH00 Q8K2G4 Q9CXC2 uc008ozq.1 uc008ozq.2 uc008ozq.3 uc008ozq.4 The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity). Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts with BBS2 (via C-terminus). Interacts with CCDC28B. Interacts with SMO; the interaction is indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO. Cell projection, cilium membrane Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cytoplasm, cytoskeleton, cilium basal body Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K2G4-1; Sequence=Displayed; Name=2; IsoId=Q8K2G4-2; Sequence=VSP_008851; Name=3; IsoId=Q8K2G4-3; Sequence=VSP_008852, VSP_008853; [Isoform 2]: May be due to a competing donor splice site. [Isoform 3]: Due to intron retention. RNA polymerase II repressing transcription factor binding eye development photoreceptor outer segment nucleus cytoplasm centrosome microtubule organizing center cytoskeleton plasma membrane cilium axoneme regulation of transcription from RNA polymerase II promoter smoothened signaling pathway brain development heart development protein localization protein transport membrane cell projection organization positive regulation of proteasomal ubiquitin-dependent protein catabolic process BBSome ciliary basal body cell projection neuron projection fat cell differentiation intracellular transport ciliary membrane limb development cilium assembly primary palate development non-motile cilium assembly uc008ozq.1 uc008ozq.2 uc008ozq.3 uc008ozq.4 
ENSMUST00000108165.8 Proser3 ENSMUST00000108165.8 proline and serine rich 3, transcript variant 2 (from RefSeq NM_183321.1) ENSMUST00000108165.1 ENSMUST00000108165.2 ENSMUST00000108165.3 ENSMUST00000108165.4 ENSMUST00000108165.5 ENSMUST00000108165.6 ENSMUST00000108165.7 NM_183321 PRSR3_MOUSE Q7TSA6 Q8C786 uc009get.1 uc009get.2 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TSA6-1; Sequence=Displayed; Name=2; IsoId=Q7TSA6-2; Sequence=VSP_027704, VSP_027705, VSP_027706; molecular_function cellular_component biological_process uc009get.1 uc009get.2 
ENSMUST00000108173.10 Rffl ENSMUST00000108173.10 ring finger and FYVE like domain containing protein, transcript variant 1 (from RefSeq NM_001007465.3) ENSMUST00000108173.1 ENSMUST00000108173.2 ENSMUST00000108173.3 ENSMUST00000108173.4 ENSMUST00000108173.5 ENSMUST00000108173.6 ENSMUST00000108173.7 ENSMUST00000108173.8 ENSMUST00000108173.9 NM_001007465 Q5SVC2 Q5SVC4 Q6ZQM0 Q9D543 Q9D9B1 RFFL_MOUSE Rffl uc007knj.1 uc007knj.2 uc007knj.3 uc007knj.4 E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with CASP8 and CASP10. Interacts with RIPK1 (via protein kinase domain); involved in RIPK1 ubiquitination. Interacts with PRR5L. Interacts (via RING-type zinc finger) with p53/TP53; involved in p53/TP53 ubiquitination. Interacts (via RING-type zinc finger) with MDM2; the interaction stabilizes MDM2. Cytoplasm, cytosol Cell membrane ; Peripheral membrane protein Recycling endosome membrane ; Peripheral membrane protein Note=The FYVE-type zinc finger may mediate phosphatidylinositol phosphate-binding and control subcellular localization. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6ZQM0-1; Sequence=Displayed; Name=2; IsoId=Q6ZQM0-2; Sequence=VSP_015753; Name=3; IsoId=Q6ZQM0-3; Sequence=VSP_015753, VSP_015754; Name=4; IsoId=Q6ZQM0-4; Sequence=VSP_015753, VSP_015754, VSP_015755, VSP_015756; Ubiquitous. Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney, testis, thymus, whole embryo and embryonic stem cells. Up-regulation by LPA/lysophosphatidic acid is dependent on GNA12. The FYVE-type zinc finger domain is required for localization to the recycling endosome membranes and the function in endocytic recycling. The RING-type zinc finger is required for the ubiquitination of target proteins. Autoubiquitinated. Palmitoylated. Undergoes caspase-mediated cleavage upon death-receptor activation, by TNFSF10 for instance. May be mediated by the caspases CASP8 and CASP10 in a negative feedback loop (By similarity). No visible phenotype. protease binding p53 binding cytoplasm endosome cytosol plasma membrane ubiquitin-dependent protein catabolic process intracellular protein transport apoptotic process endosome membrane regulation of fibroblast migration negative regulation of tumor necrosis factor-mediated signaling pathway membrane protein ubiquitination transferase activity protein kinase binding cytoplasmic vesicle ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding recycling endosome membrane ubiquitin protein ligase activity protein K48-linked ubiquitination negative regulation of signal transduction by p53 class mediator negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis uc007knj.1 uc007knj.2 uc007knj.3 uc007knj.4 
ENSMUST00000108175.8 Nfkbid ENSMUST00000108175.8 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta, transcript variant 3 (from RefSeq NM_172142.5) ENSMUST00000108175.1 ENSMUST00000108175.2 ENSMUST00000108175.3 ENSMUST00000108175.4 ENSMUST00000108175.5 ENSMUST00000108175.6 ENSMUST00000108175.7 IKBD_MOUSE Ikbns NM_172142 Q2TB02 Q3TJP0 Q8CIW1 uc291nvv.1 uc291nvv.2 Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses (PubMed:11931770, PubMed:15749903, PubMed:16410444, PubMed:16413922, PubMed:17641034). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (PubMed:25282160). According to PubMed:11931770, it may also regulate TCR-induced negative selection of thymocytes (PubMed:11931770). Interacts with NFKB1, RELA and RELB; in the nucleus. Nucleus Specifically expressed in spleen and at low levels in thymus. Expressed in a population of antigen-presenting dendritic cells which may act as regulators of systemic inflammatory response. Up-regulated in thymocytes upon TCR-triggered cell death (at protein level). Up-regulated by IL-10 or LPS. Mice are highly sensitive to LPS-induced endotoxin shock and susceptible to intestinal inflammation caused by exposure to microflora. They display no overt T-cell selection phenotype but an impaired proliferation of T-cells. Thymocytes and T- cells seem to produce less IL-2 and IFNG. Belongs to the NF-kappa-B inhibitor family. Sequence=BAE39455.1; Type=Frameshift; Evidence=; protein binding nucleus inflammatory response negative regulation of NF-kappaB transcription factor activity negative regulation of T cell differentiation in thymus negative regulation of I-kappaB kinase/NF-kappaB signaling T cell receptor signaling pathway NF-kappaB binding positive regulation of thymocyte apoptotic process positive regulation of T-helper 17 cell differentiation uc291nvv.1 uc291nvv.2 
ENSMUST00000108180.9 Bach2 ENSMUST00000108180.9 Transcriptional regulator that acts as a repressor or activator (PubMed:8887638). Binds to Maf recognition elements (MARE) (PubMed:8887638). Plays an important role in coordinating transcription activation and repression by MAFK (PubMed:8887638). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (By similarity). Positively regulates the nuclear import of actin (PubMed:26021350). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). (from UniProt P97303) A2ANU8 A2ANU9 A2RRI0 BACH2_MOUSE D86604 ENSMUST00000108180.1 ENSMUST00000108180.2 ENSMUST00000108180.3 ENSMUST00000108180.4 ENSMUST00000108180.5 ENSMUST00000108180.6 ENSMUST00000108180.7 ENSMUST00000108180.8 P97303 uc012dbf.1 uc012dbf.2 uc012dbf.3 Transcriptional regulator that acts as a repressor or activator (PubMed:8887638). Binds to Maf recognition elements (MARE) (PubMed:8887638). Plays an important role in coordinating transcription activation and repression by MAFK (PubMed:8887638). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (By similarity). Positively regulates the nuclear import of actin (PubMed:26021350). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). Homodimer; disulfide-linked (By similarity). Heterodimer of BACH2 and Maf-related transcription factors (PubMed:8887638). Cytoplasm Nucleus Note=Nucleocytoplasmic shuttling is controlled by phosphorylation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P97303-1; Sequence=Displayed; Name=2; IsoId=P97303-2; Sequence=VSP_047933; Detected in brain and spleen. In brain, expression is lower in the adult than in the neonate. The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses. Phosphorylation at Ser-520 downstream of the PI-3K pathway promotes nuclear export. Belongs to the bZIP family. CNC subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm cytosol regulation of transcription, DNA-templated nuclear import uc012dbf.1 uc012dbf.2 uc012dbf.3 
ENSMUST00000108182.10 Dcun1d1 ENSMUST00000108182.10 defective in cullin neddylation 1 domain containing 1, transcript variant 1 (from RefSeq NM_001205361.1) DCNL1_MOUSE Dcun1d1 Dcun1l1 ENSMUST00000108182.1 ENSMUST00000108182.2 ENSMUST00000108182.3 ENSMUST00000108182.4 ENSMUST00000108182.5 ENSMUST00000108182.6 ENSMUST00000108182.7 ENSMUST00000108182.8 ENSMUST00000108182.9 NM_001205361 Q3TMX2 Q8CDZ7 Q9QZ73 Rp42 SCCRO Tes3 uc008oyx.1 uc008oyx.2 uc008oyx.3 uc008oyx.4 Part of an E3 ubiquitin ligase complex for neddylation (By similarity). Promotes neddylation of cullin components of E3 cullin- RING ubiquitin ligase complexes (PubMed:26792857). Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (By similarity). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (PubMed:20563250). Part of an E3 complex for neddylation composed of cullins, RBX1, UBE2M and CAND1. Interacts (via the DCUN1 domain) with the unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5; these interactions promote the cullin neddylation and the identity of the cullin dictates the affinity of the interaction. Binds neddylated CUL1. Interacts (via the C-terminus 50 AA) directly with RBX1. Interacts (via DCUN1 domain) with the N-terminally acetylated form of UBE2M and UBE2F. Interacts preferentially with UBE2M-NEDD8 thioester (via N-terminus 1-26 AA) than with free UBE2M. UBE2M N- terminal acetylation increases the affinity of this interaction by about 2 orders of magnitude. Interacts with CAND1; this interaction is indirect and is bridged by cullins such as CUL1 and CUL3. May also interact with regulators or subunits of cullin-RING ligases such as RNF7, ELOB and DDB1; these interactions are bridged by cullins. Component of VCB complex that contains at least DCUN1D1, CUL2 and VHL; this complex triggers CUL2 neddylation and consequently cullin ring ligase (CRL) substrates polyubiquitylation. Interacts with VHL; this interaction triggers engagement of HIF1A in the VCB complex and is independent of CUL2. Interacts with CUL2 independently of VHL. Interacts with SOCS1 and SOCS2. Interacts with HIF1A; this interaction increases the interaction between VHL and DCUN1D1. Interacts (via UBA- like domain) with ARIH2; promotes DCUN1D1 ubiquitination. Nucleus Cytoplasm Note=The ubiquitinated form is localized in the cytoplasm. Highly expressed in testis (PubMed:10777668, PubMed:10831844, PubMed:26792857). Also expressed in brain, heart, liver, skeletal muscle and kidney (PubMed:10777668, PubMed:10831844). In brain, preferentially expressed in the telencephalon ventricular and subventricular zones, albeit at low levels (PubMed:10777668). In adult testis, expressed in cells above seminiferous tubules, but only weakly in spermatogonia (PubMed:10831844). Expressed in the developing forebrain, midbrain and hindbrain at early stages of neuronal development. The DCUN1 domain, also known as PONY domain, mediates the interaction with different cullins. The DCUN1 domain mediates the interaction with the N-terminally acetylated NEDD8-conjugating E2s enzyme leading to the NEDD8 transfer from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes; the neddylation efficiency correlates with the DCUN1D1- cullin and DCUN1D1-E2 interaction affinities. The UBA-like domain mediates interaction with autoubiquitylated ARIH2 leading to ubiquitin ligation to DCUN1D1. Mono- and poly-ubiquitinated by ARIH2 and ARIH1. Monoubiquitination by ARIH2 is mediated by an interaction between autoubiquitinated ARIH2 and the UBA-like domain. The monoubiquitinated form preferentially interacts with non-neddylated cullins and modulates cullin RING ligase (CRL) complex composition and activity. Reduced neddylation of Cul3 in lysates from testis. Sequence=BAC26390.1; Type=Erroneous initiation; Evidence=; ubiquitin ligase complex nucleus cytosol ubiquitin conjugating enzyme binding ubiquitin-like protein binding protein neddylation positive regulation of ubiquitin-protein transferase activity cullin family protein binding positive regulation of protein neddylation uc008oyx.1 uc008oyx.2 uc008oyx.3 uc008oyx.4 
ENSMUST00000108187.9 1700020L13Rik ENSMUST00000108187.9 RIKEN cDNA 1700020L13 gene (from RefSeq NR_144498.1) ENSMUST00000108187.1 ENSMUST00000108187.2 ENSMUST00000108187.3 ENSMUST00000108187.4 ENSMUST00000108187.5 ENSMUST00000108187.6 ENSMUST00000108187.7 ENSMUST00000108187.8 NR_144498 uc009gdz.1 uc009gdz.2 uc009gdz.3 uc009gdz.4 uc009gdz.1 uc009gdz.2 uc009gdz.3 uc009gdz.4 
ENSMUST00000108189.9 Ccl1 ENSMUST00000108189.9 C-C motif chemokine ligand 1 (from RefSeq NM_011329.3) Ccl1 ENSMUST00000108189.1 ENSMUST00000108189.2 ENSMUST00000108189.3 ENSMUST00000108189.4 ENSMUST00000108189.5 ENSMUST00000108189.6 ENSMUST00000108189.7 ENSMUST00000108189.8 NM_011329 Q0VB35 Q0VB35_MOUSE uc007kmu.1 uc007kmu.2 uc007kmu.3 Secreted Belongs to the intercrine beta (chemokine CC) family. cytokine activity extracellular region extracellular space chemotaxis immune response signal transduction chemokine activity cell chemotaxis uc007kmu.1 uc007kmu.2 uc007kmu.3 
ENSMUST00000108190.8 Wdr62 ENSMUST00000108190.8 WD repeat domain 62, transcript variant 12 (from RefSeq NR_176792.1) E9QK36 E9QK36_MOUSE ENSMUST00000108190.1 ENSMUST00000108190.2 ENSMUST00000108190.3 ENSMUST00000108190.4 ENSMUST00000108190.5 ENSMUST00000108190.6 ENSMUST00000108190.7 NR_176792 Wdr62 uc009gdx.1 uc009gdx.2 uc009gdx.3 uc009gdx.4 spindle pole nucleus centrosome microtubule organizing center cytosol mitotic spindle organization centriole replication cerebral cortex development neurogenesis uc009gdx.1 uc009gdx.2 uc009gdx.3 uc009gdx.4 
ENSMUST00000108195.10 Dnajc19 ENSMUST00000108195.10 DnaJ heat shock protein family (Hsp40) member C19, transcript variant 1 (from RefSeq NM_026332.4) Dnajc19 ENSMUST00000108195.1 ENSMUST00000108195.2 ENSMUST00000108195.3 ENSMUST00000108195.4 ENSMUST00000108195.5 ENSMUST00000108195.6 ENSMUST00000108195.7 ENSMUST00000108195.8 ENSMUST00000108195.9 NM_026332 Q8R1N1 Q9CQV7 Q9D896 TIM14_MOUSE Tim14 Timm14 uc008oxo.1 uc008oxo.2 uc008oxo.3 uc008oxo.4 Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (PubMed:24856930). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). Interacts with PHB2; the interaction associates DNAJC19 with the prohibitin complex (PubMed:24856930). Interacts with TIMM16/PAM16 (PubMed:24856930). May be a component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9CQV7-1; Sequence=Displayed; Name=2; IsoId=Q9CQV7-2; Sequence=VSP_016390; Name=3; IsoId=Q9CQV7-3; Sequence=VSP_016391; Belongs to the TIM14 family. presequence translocase-associated import motor ATPase activator activity mitochondrion mitochondrial inner membrane visual perception protein transport membrane integral component of membrane protein import into mitochondrial matrix positive regulation of ATPase activity macromolecular complex genitalia development uc008oxo.1 uc008oxo.2 uc008oxo.3 uc008oxo.4 
ENSMUST00000108204.2 Fhl5 ENSMUST00000108204.2 four and a half LIM domains 5, transcript variant 3 (from RefSeq NM_001379528.1) Act ENSMUST00000108204.1 FHL5_MOUSE NM_001379528 Q9WTX7 uc290lmq.1 uc290lmq.2 May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner (By similarity). Interacts with CREM (via the third LIM domain) (PubMed:10086359). Interacts (via second LIM domain) with SPAG8 (PubMed:20488182). Q9WTX7; Q3V0Q6: Spag8; NbExp=5; IntAct=EBI-7530396, EBI-7981981; Nucleus Note=Nuclei of round and elongated spermatids. Testis-specific, temporal expression is coordinated with CREM. transcription coactivator activity protein binding nucleus transcription, DNA-templated Z disc positive regulation of transcription from RNA polymerase II promoter metal ion binding uc290lmq.1 uc290lmq.2 
ENSMUST00000108205.9 Zfp74 ENSMUST00000108205.9 zinc finger protein 74 (from RefSeq NM_178384.4) E9QK35 ENSMUST00000108205.1 ENSMUST00000108205.2 ENSMUST00000108205.3 ENSMUST00000108205.4 ENSMUST00000108205.5 ENSMUST00000108205.6 ENSMUST00000108205.7 ENSMUST00000108205.8 NM_178384 O88237 Q80W31 ZN569_MOUSE Znf569 uc009gcr.1 uc009gcr.2 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated biological_process metal ion binding uc009gcr.1 uc009gcr.2 
ENSMUST00000108210.9 Ttc14 ENSMUST00000108210.9 tetratricopeptide repeat domain 14, transcript variant 1 (from RefSeq NM_027619.5) A0A8V5I5B0 A0A8V5I5B0_MOUSE ENSMUST00000108210.1 ENSMUST00000108210.2 ENSMUST00000108210.3 ENSMUST00000108210.4 ENSMUST00000108210.5 ENSMUST00000108210.6 ENSMUST00000108210.7 ENSMUST00000108210.8 NM_027619 Ttc14 uc008oxc.1 uc008oxc.2 uc008oxc.3 uc008oxc.4 uc008oxc.1 uc008oxc.2 uc008oxc.3 uc008oxc.4 
ENSMUST00000108218.10 Klhl32 ENSMUST00000108218.10 kelch-like 32, transcript variant 1 (from RefSeq NM_001163020.2) A2AJX0 A2AJX0_MOUSE ENSMUST00000108218.1 ENSMUST00000108218.2 ENSMUST00000108218.3 ENSMUST00000108218.4 ENSMUST00000108218.5 ENSMUST00000108218.6 ENSMUST00000108218.7 ENSMUST00000108218.8 ENSMUST00000108218.9 Klhl32 NM_001163020 uc012dba.1 uc012dba.2 uc012dba.3 uc012dba.1 uc012dba.2 uc012dba.3 
ENSMUST00000108222.9 Mms22l ENSMUST00000108222.9 MMS22-like, DNA repair protein, transcript variant 2 (from RefSeq NR_149739.1) B1AUR6 B7ZN61 D3YXA0 ENSMUST00000108222.1 ENSMUST00000108222.2 ENSMUST00000108222.3 ENSMUST00000108222.4 ENSMUST00000108222.5 ENSMUST00000108222.6 ENSMUST00000108222.7 ENSMUST00000108222.8 MMS22_MOUSE NR_149739 Q6R5F9 Q80UT0 uc008sdx.1 uc008sdx.2 uc008sdx.3 uc008sdx.4 uc008sdx.5 Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L- TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single- stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, MMS22L acts by binding ssDNA. Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2. Interacts with RAD51; interaction is direct. Nucleus Chromosome Note=Localizes to DNA damage sites, accumulates at stressed replication forks. Recruited to stalled or collapsed replication forks; directly binds replication protein A complex (RPA/RP-A)-coated single-stranded DNA (ssDNA). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B1AUR6-1; Sequence=Displayed; Name=2; IsoId=B1AUR6-2; Sequence=VSP_040445, VSP_040446; Degraded by the ubiquitin-proteasome system upon replication stress. Belongs to the MMS22 family. MMS22L subfamily. Sequence=AAI37911.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI45029.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; double-strand break repair via homologous recombination molecular_function nucleus nucleoplasm cytosol DNA repair cellular response to DNA damage stimulus replication fork processing FACT complex MCM complex nuclear replication fork uc008sdx.1 uc008sdx.2 uc008sdx.3 uc008sdx.4 uc008sdx.5 
ENSMUST00000108238.8 Yif1b ENSMUST00000108238.8 Yip1 interacting factor homolog B (S. cerevisiae), transcript variant 5 (from RefSeq NM_001357668.1) ENSMUST00000108238.1 ENSMUST00000108238.2 ENSMUST00000108238.3 ENSMUST00000108238.4 ENSMUST00000108238.5 ENSMUST00000108238.6 ENSMUST00000108238.7 NM_001357668 Q32M25 Q3UXJ5 Q9CX30 YIF1B_MOUSE Yif1b uc009gbh.1 uc009gbh.2 uc009gbh.3 uc009gbh.4 Functions in endoplasmic reticulum to Golgi vesicle-mediated transport and regulates the proper organization of the endoplasmic reticulum and the Golgi (PubMed:26077767, PubMed:33103737). Plays a key role in targeting to neuronal dendrites receptors such as HTR1A (By similarity). Also plays a role in primary cilium and sperm flagellum assembly probably through protein transport to these compartments (PubMed:33103737). Interacts with HTR1A (via C-terminus) (By similarity). Interacts with ABCB9 (via TMD0); this interaction allows (but is not essential) the ER-to-Golgi trafficking and strongly depends on a salt bridge within TMD0 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Note=Shuttles between the endoplasmic reticulum, the intermediate compartment and the Golgi apparatus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CX30-1; Sequence=Displayed; Name=2; IsoId=Q9CX30-2; Sequence=VSP_028656; Highly expressed in brain. Expressed in Purkinje cells of the cerebellum. Homozygous knockout mice lacking Yif1b show impaired visual perception associated with retinal dysfunction and optic atrophy while no ventilator defects or increased susceptibility to seizures is observed. Some deficits in fine motor skills and coordination are also observed. Mutant mice have delayed cerebral myelination, enlarged ventricles, and cerebellar atrophy associated with a reduction in the number of Purkinje cells due to neurodegeneration and necrosis. Purkinje cells show fragmentation of the Golgi apparatus, large autophagosome-like vacuoles, and alteration of the endoplasmic reticulum with dilated cisternae. Male knockout mice are infertile due to abnormal spermatozoa flagella that show microtubule disorganization. Primary cilium abnormalities are also observed in cerebellar Purkinje cells and hippocampal pyramidal cells, for instance. Belongs to the YIF1 family. molecular_function endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment ER to Golgi vesicle-mediated transport membrane integral component of membrane ER to Golgi transport vesicle integral component of Golgi membrane uc009gbh.1 uc009gbh.2 uc009gbh.3 uc009gbh.4 
ENSMUST00000108241.8 Utp6 ENSMUST00000108241.8 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. (from UniProt Q8VCY6) AK084976 ENSMUST00000108241.1 ENSMUST00000108241.2 ENSMUST00000108241.3 ENSMUST00000108241.4 ENSMUST00000108241.5 ENSMUST00000108241.6 ENSMUST00000108241.7 Mhat Q8CH76 Q8VCY6 UTP6_MOUSE uc288ari.1 uc288ari.2 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus Belongs to the UTP6 family. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleus nucleolus rRNA processing RNA processing snoRNA binding small-subunit processome Pwp2p-containing subcomplex of 90S preribosome uc288ari.1 uc288ari.2 
ENSMUST00000108243.8 Pik3ca ENSMUST00000108243.8 Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (PubMed:19604150). (from UniProt P42337) BC089038 ENSMUST00000108243.1 ENSMUST00000108243.2 ENSMUST00000108243.3 ENSMUST00000108243.4 ENSMUST00000108243.5 ENSMUST00000108243.6 ENSMUST00000108243.7 P42337 PK3CA_MOUSE Q0VGQ5 uc290ejg.1 uc290ejg.2 Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (PubMed:19604150). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+); Xref=Rhea:RHEA:21292, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57836, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.153; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21293; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+); Xref=Rhea:RHEA:12709, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088, ChEBI:CHEBI:456216; EC=2.7.1.137; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12710; Evidence=; Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+); Xref=Rhea:RHEA:55632, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:83416, ChEBI:CHEBI:83419, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55633; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero- 3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo- inositol 3,4,5-triphosphate) + ADP + H(+); Xref=Rhea:RHEA:43396, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77137, ChEBI:CHEBI:83243, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43397; Evidence=; Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3) (PubMed:8139567). Interacts with IRS1 in nuclear extracts (PubMed:15197263). Interacts with RUFY3. Interacts with RASD2. Interacts with APPL1 (By similarity). Interacts with HRAS and KRAS (PubMed:17540175). Interaction with HRAS/KRAS is required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2 (PubMed:17540175). Interacts with FAM83B; activates the PI3K/AKT signaling cascade (By similarity). P42337; P41241: Csk; NbExp=2; IntAct=EBI-641748, EBI-2553183; P42337; P26450: Pik3r1; NbExp=7; IntAct=EBI-641748, EBI-641764; P42337; P01112: HRAS; Xeno; NbExp=2; IntAct=EBI-641748, EBI-350145; The PI3K-ABD domain and the PI3K-RBD domain interact with the PI3K/PI4K kinase domain. The C2 PI3K-type domain may facilitate the recruitment to the plasma membrane. The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1, and the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1. Lethal. Embryonic fibroblasts cells are resistant to oncogenic transformation induced by oncogenic receptor tyrosine kinases (RTKs), are unable to differentiate into adipocytes and deficient in cellular signaling in response to various growth factors. Defective responsiveness to insulin led to reduced somatic growth, hyperinsulinemia, glucose intolerance, hyperphagia and increased adiposity. Belongs to the PI3/PI4-kinase family. nucleotide binding angiogenesis liver development regulation of protein phosphorylation protein serine/threonine kinase activity protein binding ATP binding cytoplasm cytosol plasma membrane phosphatidylinositol 3-kinase complex phosphatidylinositol 3-kinase complex, class IA glucose metabolic process protein phosphorylation phagocytosis regulation of gene expression negative regulation of gene expression phosphatidylinositol 3-kinase signaling membrane kinase activity 1-phosphatidylinositol-3-kinase activity phosphorylation transferase activity lamellipodium protein kinase activator activity activation of protein kinase activity positive regulation of peptidyl-serine phosphorylation phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity phosphatidylinositol-3-phosphate biosynthetic process regulation of multicellular organism growth regulation of cellular respiration protein kinase B signaling negative regulation of neuron apoptotic process insulin receptor substrate binding hypomethylation of CpG island phosphatidylinositol phosphorylation phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphatidylinositol-mediated signaling positive regulation of smooth muscle cell proliferation phosphatidylinositol-3,4-bisphosphate 5-kinase activity adipose tissue development cellular response to glucose stimulus energy homeostasis negative regulation of fibroblast apoptotic process regulation of genetic imprinting negative regulation of anoikis uc290ejg.1 uc290ejg.2 
ENSMUST00000108246.9 Wwp1 ENSMUST00000108246.9 WW domain containing E3 ubiquitin protein ligase 1, transcript variant 4 (from RefSeq NR_074090.1) ENSMUST00000108246.1 ENSMUST00000108246.2 ENSMUST00000108246.3 ENSMUST00000108246.4 ENSMUST00000108246.5 ENSMUST00000108246.6 ENSMUST00000108246.7 ENSMUST00000108246.8 NR_074090 Q8BIV9 Q8BZZ3 Q8VDP8 WWP1_MOUSE uc008scc.1 uc008scc.2 uc008scc.3 uc008scc.4 uc008scc.5 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF (By similarity). Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Activated by NDFIP1- and NDFIP2-binding. Protein modification; protein ubiquitination. Binds SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, DRPLA and adenovirus type 2 PIII. Interacts with TGIF (By similarity). Binds KLF2 AND HIVEP3. Interacts with RNF11. Interacts with SPART. Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase (By similarity). Interacts with ERBB4 isoforms JM-B CYT-1 and JM-A CYT-1. Does not interact with ERB4 isoform JMA-A CYT-2. Interacts with SMAD1, SMAD2, SMAD3, SMAD5, SMAD6, SMAD7, TGFBR1 and TGFBR2. Associates with the TGFBR1:TGFBR2 receptor complex in presence of SMAD7. Interacts with SKIL isoform 1. Interacts with TP63 isoform 1 and isoform 2. Interacts (via WW domains) with ARRDC1, ARRDC2 and ARRDC3 (By similarity). Cytoplasm Cell membrane ; Peripheral membrane protein Nucleus The WW domains mediate interaction with PPxY motif-containing proteins. Auto-ubiquitinated and ubiquitinated by RNF11. Sequence=AAH21470.1; Type=Erroneous initiation; Evidence=; Sequence=BAC38473.1; Type=Miscellaneous discrepancy; Note=Chimera. The second part of the clone maps to another chromosome.; Evidence=; protein polyubiquitination ubiquitin-protein transferase activity protein binding nucleus cytoplasm cytosol plasma membrane ubiquitin-dependent protein catabolic process membrane protein ubiquitination transferase activity T cell differentiation lung development proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process negative regulation of transcription, DNA-templated ubiquitin protein ligase activity uc008scc.1 uc008scc.2 uc008scc.3 uc008scc.4 uc008scc.5 
ENSMUST00000108249.9 Prkci ENSMUST00000108249.9 protein kinase C, iota (from RefSeq NM_008857.3) ENSMUST00000108249.1 ENSMUST00000108249.2 ENSMUST00000108249.3 ENSMUST00000108249.4 ENSMUST00000108249.5 ENSMUST00000108249.6 ENSMUST00000108249.7 ENSMUST00000108249.8 KPCI_MOUSE NM_008857 Pkcl Q62074 uc008ovs.1 uc008ovs.2 uc008ovs.3 Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI3K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis (By similarity). Downstream of PI3K is required for insulin-stimulated glucose transport. Activates RAB4A and promotes its association with KIF3A which is required for the insulin-induced SLC2A4/GLUT4 translocation in adipocytes. Is essential in early embryogenesis and development of differentiating photoreceptors by playing a role in the establishment of epithelial and neuronal polarity. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-411 (activation loop of the kinase domain) and Thr-563 (turn motif), need to be phosphorylated for its full activation (By similarity). Might also be a target for novel lipid activators that are elevated during nutrient-stimulated insulin secretion. Forms a complex with SQSTM1 and MP2K5 (PubMed:12813044). Interacts directly with SQSTM1 (Probable). Interacts with IKBKB. Interacts with PARD6A, PARD6B and PARD6G. Part of a quaternary complex containing aPKC, PARD3, a PARD6 protein (PARD6A, PARD6B or PARD6G) and a GTPase protein (CDC42 or RAC1) (PubMed:10934474). Part of a complex with LLGL1 and PARD6B. Interacts with ADAP1/CENTA1. Interaction with SMG1, through the ZN-finger domain, activates the kinase activity. Interacts with CDK7. Forms a complex with RAB2A and GAPDH involved in recruitment onto the membrane of vesicular tubular clusters (VTCs). Interacts with ECT2 ('Thr-359' phosphorylated form) (By similarity). Interacts with VAMP2 (PubMed:17313651). Interacts with WDFY2 (via WD repeats 1-3) (PubMed:16792529). Q62074; Q8R1S4: Mtss1; NbExp=4; IntAct=EBI-82016, EBI-15622277; Q62074; Q8TEW0: PARD3; Xeno; NbExp=7; IntAct=EBI-82016, EBI-81968; Cytoplasm Membrane Endosome Nucleus Note=Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A. Expressed apically in the cortical neuroepithelium along the ventricular surface at 14.5 dpc. The PB1 domain mediates interaction with SQSTM1. The C1 zinc finger does not bind diacylglycerol (DAG). The pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins, except the presence of a non- phosphorylatable residue in place of Ser, it modulates activity by competing with substrates. Phosphorylation at Thr-411 in the activation loop is not mandatory for activation (PubMed:22579248). Upon neuronal growth factor (NGF) stimulation, phosphorylated by SRC at Tyr-264, Tyr-279 and Tyr-333 (By similarity). Phosphorylation on Tyr-264 facilitates binding to KPNB1/importin-beta regulating entry of PRKCI into the nucleus (By similarity). Phosphorylation on Tyr-333 is important for NF-kappa-B stimulation (By similarity). Phosphorylated at Thr-563 during the initial phase of long term potentiation (By similarity). Embryonic lethal at 9.5 dpc. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. Sequence=AAH21630.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAA32499.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi membrane nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding phospholipid binding nucleus cytoplasm endosome cytosol plasma membrane bicellular tight junction protein phosphorylation actin filament organization multicellular organism development positive regulation of neuron projection development microtubule cytoskeleton membrane kinase activity phosphorylation apical plasma membrane cell migration transferase activity peptidyl-serine phosphorylation cell leading edge cellular response to insulin stimulus negative regulation of glial cell apoptotic process cellular protein localization establishment of apical/basal cell polarity intracellular signal transduction eye photoreceptor cell development Schmidt-Lanterman incisure response to peptide hormone negative regulation of neuron apoptotic process intercellular bridge apical part of cell cell-cell junction organization positive regulation of glucose import metal ion binding Golgi vesicle budding positive regulation of NF-kappaB transcription factor activity positive regulation of glial cell proliferation response to interleukin-1 glutamatergic synapse regulation of postsynaptic specialization membrane neurotransmitter receptor levels positive regulation of protein localization to plasma membrane positive regulation of endothelial cell apoptotic process uc008ovs.1 uc008ovs.2 uc008ovs.3 
ENSMUST00000108250.3 Gm12353 ENSMUST00000108250.3 Gm12353 (from geneSymbol) AK009059 ENSMUST00000108250.1 ENSMUST00000108250.2 uc290ljm.1 uc290ljm.2 uc290ljm.1 uc290ljm.2 
ENSMUST00000108262.10 Samd7 ENSMUST00000108262.10 sterile alpha motif domain containing 7, transcript variant 1 (from RefSeq NM_029489.4) ENSMUST00000108262.1 ENSMUST00000108262.2 ENSMUST00000108262.3 ENSMUST00000108262.4 ENSMUST00000108262.5 ENSMUST00000108262.6 ENSMUST00000108262.7 ENSMUST00000108262.8 ENSMUST00000108262.9 F8WHA0 G3UXH0 NM_029489 Q8C8Y5 SAMD7_MOUSE uc012cof.1 uc012cof.2 uc012cof.3 Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes. Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C8Y5-1; Sequence=Displayed; Name=2; IsoId=Q8C8Y5-3; Sequence=VSP_059092, VSP_059093; Expressed in the retina and the pineal gland. In the retina, it is predominantly expressed in the outer nuclear layer. Transcriptionally regulated by CRX. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=BAC31828.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; molecular_function nucleus cytoplasm negative regulation of gene expression uc012cof.1 uc012cof.2 uc012cof.3 
ENSMUST00000108265.3 Lrriq4 ENSMUST00000108265.3 leucine-rich repeats and IQ motif containing 4, transcript variant 2 (from RefSeq NM_001290510.2) A6H6A4 ENSMUST00000108265.1 ENSMUST00000108265.2 LRIQ4_MOUSE NM_001290510 Q9D5Q5 uc008ovd.1 uc008ovd.2 uc008ovd.3 uc008ovd.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A6H6A4-1; Sequence=Displayed; Name=2; IsoId=A6H6A4-2; Sequence=VSP_033339; uc008ovd.1 uc008ovd.2 uc008ovd.3 uc008ovd.4 
ENSMUST00000108268.10 Lgals9 ENSMUST00000108268.10 lectin, galactose binding, soluble 9, transcript variant 2 (from RefSeq NM_001159301.1) ENSMUST00000108268.1 ENSMUST00000108268.2 ENSMUST00000108268.3 ENSMUST00000108268.4 ENSMUST00000108268.5 ENSMUST00000108268.6 ENSMUST00000108268.7 ENSMUST00000108268.8 ENSMUST00000108268.9 LEG9_MOUSE NM_001159301 O08572 O08573 Q3UKE5 Q99L83 uc007kke.1 uc007kke.2 uc007kke.3 uc007kke.4 Binds galactosides (By similarity). Has high affinity for the Forssman pentasaccharide (By similarity). Ligand for HAVCR2/TIM3 (By similarity). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (By similarity). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (PubMed:20937702). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (PubMed:25065622). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (By similarity). Expands regulatory T- cells and induces cytotoxic T-cell apoptosis following virus infection (By similarity). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (By similarity). Inhibits degranulation and induces apoptosis of mast cells (By similarity). Induces maturation and migration of dendritic cells (By similarity). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (By similarity). Astrocyte derived galectin-9 enhances microglial TNF production (PubMed:25158758). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity). [Isoform 2]: Acts as an eosinophil chemoattractant (By similarity). It also inhibits angiogenesis (By similarity). Suppresses IFNG production by natural killer cells. Homodimer. O08573; P15379: Cd44; NbExp=2; IntAct=EBI-8377586, EBI-7565891; O08573-2; Q8VIM0: Havcr2; NbExp=4; IntAct=EBI-11316797, EBI-6665112; Cytoplasm Nucleus Secreted Note=May also be secreted by a non-classical secretory pathway (PubMed:9038233). Secreted by mesenchymal stromal cells upon IFNG stimulation (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long, FL ; IsoId=O08573-1; Sequence=Displayed; Name=2; Synonyms=Short, D5 ; IsoId=O08573-2; Sequence=VSP_003097; Name=3; Synonyms=D5/6 ; IsoId=O08573-3; Sequence=VSP_003097, VSP_057844; Accentuated expression in liver and thymus of embryo, detected in embryonic heart, brain, lung, liver, and kidney. Highly expressed in adult thymus, small intestine, and liver, and to a lesser extent in lung, kidney, spleen, cardiac, and skeletal muscle. Barely detectable in brain and reticulocyte. Expressed in placenta, uterus and decidua during pregnancy (PubMed:23242525). Expressed in CD4+ T-cells with higher levels in iTreg cells than other T-cell types and sustained high levels throughout iTreg cell differentiation (at protein level) (PubMed:25065622). Expressed in myeloid cells in lung (PubMed:20937702). Constitutively expressed in microglia (PubMed:25158758). Isoform 1 is expressed exclusively in the small intestine. Isoform 2 expression in decidua increases in pathological pregnancy from gestation day 7.5 to 13.5 and it is higher than in normal pregnancy (PubMed:23242525). Isoform 3 expression in decidua is higher in normal pregnancy than in pathological pregnancy (PubMed:23242525). The expression increases with successive stages of embryonic development. By viral mimic polyinosinic:polycytidylic acid (poly I:C) and lipopolysaccharides (LPS) in microglia (PubMed:25158758). Up- regulated in macrophages following infection with Mycobacterium tuberculosis (PubMed:20937702). Contains two homologous but distinct carbohydrate-binding domains. Increased natural killer (NK) cell activity with enhanced degranulation, higher expression of NK cell activating receptors, increased frequency of intermediate and mature NK cells, and greater production of interferon-gamma following murine cytomegalovirus infection (PubMed:23408620). Defective iTreg cell differentiation with impaired Foxp3 expression, reduced stability and suppressor function of iTreg cells and reduced frequency of iTreg cells but not natural regulatory T (nTreg) cells in lamina propria (PubMed:25065622). positive regulation of cytokine production immune system process receptor binding protein binding extracellular region nucleus cytoplasm cytosol chemotaxis heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules female pregnancy positive regulation of gene expression negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation galactoside binding enzyme binding carbohydrate binding response to lipopolysaccharide negative regulation of interferon-gamma production positive regulation of chemokine production positive regulation of interleukin-1 production positive regulation of tumor necrosis factor production negative regulation of natural killer cell activation regulation of natural killer cell differentiation toll-like receptor 3 signaling pathway positive regulation of macrophage activation negative regulation of natural killer cell degranulation protein serine/threonine kinase activator activity positive regulation of innate immune response maintenance of protein location positive regulation of regulatory T cell differentiation negative regulation of inflammatory response positive regulation of oxidoreductase activity positive regulation of protein serine/threonine kinase activity cellular response to virus positive regulation of defense response to bacterium negative regulation of interferon-gamma secretion positive regulation of T cell migration negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of transcription regulatory region DNA binding positive regulation of interleukin-6 secretion positive regulation of interleukin-10 secretion regulation of T cell chemotaxis regulation of T cell differentiation in thymus regulation of T-helper 17 type immune response uc007kke.1 uc007kke.2 uc007kke.3 uc007kke.4 
ENSMUST00000108277.3 Tnfaip1 ENSMUST00000108277.3 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA- dependent DNA polymerase delta activity (By similarity). (from UniProt O70479) AK034305 BACD2_MOUSE ENSMUST00000108277.1 ENSMUST00000108277.2 Edp1 O70479 Q3TH85 Q3UGQ5 Q8BV61 Q8BZK5 uc007kjq.1 uc007kjq.2 uc007kjq.3 uc007kjq.4 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA- dependent DNA polymerase delta activity (By similarity). Protein modification; protein ubiquitination. Component of the BCR(TNFAIP1) E3 ubiquitin ligase complex, at least composed of CUL3, TNFAIP1/BACURD2 and RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with RHOB. Interacts with PCNA. Interacts with CSNK2B (By similarity). Cytoplasm Nucleus Endosome Note=Colocalizes with RHOB in endosomes. Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA. Belongs to the BACURD family. ubiquitin-protein transferase activity nucleus nucleolus cytoplasm endosome DNA replication immune response cell migration protein ubiquitination GTP-Rho binding protein domain specific binding Cul3-RING ubiquitin ligase complex negative regulation of Rho protein signal transduction identical protein binding stress fiber assembly proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of DNA replication protein homooligomerization uc007kjq.1 uc007kjq.2 uc007kjq.3 uc007kjq.4 
ENSMUST00000108281.8 Fbxo27 ENSMUST00000108281.8 F-box protein 27, transcript variant 4 (from RefSeq NM_001384172.1) ENSMUST00000108281.1 ENSMUST00000108281.2 ENSMUST00000108281.3 ENSMUST00000108281.4 ENSMUST00000108281.5 ENSMUST00000108281.6 ENSMUST00000108281.7 FBX27_MOUSE NM_001384172 Q3TYP0 Q6DIA9 Q8BKF7 uc009fzk.1 uc009fzk.2 uc009fzk.3 uc009fzk.4 uc009fzk.5 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind complex-type oligosaccharides. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6DIA9-1; Sequence=Displayed; Name=2; IsoId=Q6DIA9-2; Sequence=VSP_013054; Detected in brain, heart and muscle. [Isoform 2]: May be due to a competing acceptor splice site. protein binding cytoplasm glycoprotein catabolic process protein ubiquitination SCF ubiquitin ligase complex ER-associated ubiquitin-dependent protein catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin protein ligase activity uc009fzk.1 uc009fzk.2 uc009fzk.3 uc009fzk.4 uc009fzk.5 
ENSMUST00000108283.8 Pak4 ENSMUST00000108283.8 p21 (RAC1) activated kinase 4 (from RefSeq NM_027470.3) ENSMUST00000108283.1 ENSMUST00000108283.2 ENSMUST00000108283.3 ENSMUST00000108283.4 ENSMUST00000108283.5 ENSMUST00000108283.6 ENSMUST00000108283.7 Kiaa1142 NM_027470 PAK4_MOUSE Q6ZPX0 Q80Z97 Q8BTW9 Q9CS71 uc009fzh.1 uc009fzh.2 uc009fzh.3 Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell- cycle regulatory protein CDKN1A and by phosphorylating RAN. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Inhibited by INKA1; which inhibits the serine/threonine-protein kinase activity by binding PAK4 in a substrate-like manner. Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and weakly with RAC1 (By similarity). Interacts with FGFR2 and GRB2 (PubMed:12529371). Interacts with INKA1. Interacts with SH3RF2 (By similarity). Cytoplasm Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. Autophosphorylated on serine residues when activated by CDC42/p21 (By similarity). Phosphorylated on tyrosine residues upon stimulation of FGFR2 (PubMed:12529371). Methylated by SETD6. Polyubiquitinated, leading to its proteasomal degradation. Mice die at embryonic day 11.5 probably due to a defect in the fetal heart. They show strong defects in neuronal development and axonal outgrowth. Spinal cord motor neurons and interneurons failed to differentiate and migrate to their proper position. Nervous system-specific conditional PAK4 deletion mice display growth retardation and die prematurely. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Sequence=BAC98108.2; Type=Erroneous initiation; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm protein phosphorylation apoptotic process cell cycle kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation activation of protein kinase activity positive regulation of angiogenesis dendritic spine development cellular response to organic cyclic compound negative regulation of endothelial cell apoptotic process uc009fzh.1 uc009fzh.2 uc009fzh.3 
ENSMUST00000108288.9 Lrfn1 ENSMUST00000108288.9 leucine rich repeat and fibronectin type III domain containing 1, transcript variant 5 (from RefSeq NM_001420204.1) ENSMUST00000108288.1 ENSMUST00000108288.2 ENSMUST00000108288.3 ENSMUST00000108288.4 ENSMUST00000108288.5 ENSMUST00000108288.6 ENSMUST00000108288.7 ENSMUST00000108288.8 LRFN1_MOUSE NM_001420204 Q2WF71 Q460M4 Q8C1V9 Q99KT6 Salm2 Semo1 uc291nko.1 uc291nko.2 Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1. Can form heteromeric complexes with LRFN2, LRFN3, LRFN4 and LRFN5. Forms homomeric complexes, but not across cell junctions. Interacts with DLG4. Interacts also with DLG1, DLG2, and DLG3 (By similarity). Interacts with 2 AMPA receptor subunits GRIA1 and GRIA2 and NMDA receptor subunit GRIN1. Membrane ; Single-pass type I membrane protein Synapse Postsynaptic density membrane Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q2WF71-1; Sequence=Displayed; Name=2; IsoId=Q2WF71-2; Sequence=VSP_033618, VSP_033619; Name=3; IsoId=Q2WF71-3; Sequence=VSP_033617; Predominantly expressed in the brain, with a weak, but broad expression in the cerebral cortex and diencephalic nuclei. Also detected in other parts of the central nervous system, including the olfactory bulb, pons, cerebellum, and medulla oblongata, as well as in the peripheral nervous system, such as the ganglia of cranial nerves and the dorsal root ganglion during gestation. Expression starts around 10.5 dpc. At 11.5 dpc, broadly expressed in the telencephalic and diencephalic vesicles. This pattern of expression continues until 17.5 dpc. The PDZ-binding motif is required for neurite outgrowth promotion. This motif is also involved in DLG1-, DLG3- and DLG4-binding (By similarity). Glycosylated. Belongs to the LRFN family. Sequence=BAC41123.1; Type=Frameshift; Evidence=; protein binding plasma membrane cell surface postsynaptic density membrane integral component of membrane cell junction synapse postsynaptic membrane integral component of postsynaptic density membrane uc291nko.1 uc291nko.2 
ENSMUST00000108292.9 Gmfg ENSMUST00000108292.9 glia maturation factor, gamma, transcript variant 1 (from RefSeq NM_022024.3) ENSMUST00000108292.1 ENSMUST00000108292.2 ENSMUST00000108292.3 ENSMUST00000108292.4 ENSMUST00000108292.5 ENSMUST00000108292.6 ENSMUST00000108292.7 ENSMUST00000108292.8 GMFG_MOUSE NM_022024 Q9ERL7 uc009fyx.1 uc009fyx.2 uc009fyx.3 Belongs to the actin-binding proteins ADF family. GMF subfamily. actin binding signal transduction growth factor activity actin cortical patch negative regulation of Arp2/3 complex-mediated actin nucleation actin filament debranching Arp2/3 complex binding regulation of actin cytoskeleton reorganization uc009fyx.1 uc009fyx.2 uc009fyx.3 
ENSMUST00000108294.2 Foxn1 ENSMUST00000108294.2 forkhead box N1, transcript variant 1 (from RefSeq NM_008238.2) ENSMUST00000108294.1 FOXN1_MOUSE Fkh19 Hfh11 NM_008238 Q61575 Whn uc007kjd.1 uc007kjd.2 uc007kjd.3 uc007kjd.4 The protein encoded by this gene is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. This gene family has over 100 members, subdivided into classes (A-Q) based on phylogeny. The encoded protein is proposed to regulate development of the thymus and differentiation of keratinocytes. Mutations in this gene cause severe primary T-cell immunodeficiency and congenital alopecia. In mouse mutations of this gene underlie the phenotype of the nude mouse, which has been widely used as a model system in oncology, immunology, dermatology, and transplantation studies. In humans mutations in this gene have been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]. Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs) (PubMed:22072979). Essential for maintenance of mTECs population in the postnatal thymus (PubMed:19955175). Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus (PubMed:21109991). Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age (PubMed:24184560). Essential for the vascularization of the thymus anlage (PubMed:19853842). Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (PubMed:17459087). Nucleus. Bone marrow (at protein level). Expressed in thymus and skin. Note=Defects in FOXN1 are the cause of the nude/severe combined immunodeficiency (SCID) phenotype which is characterized by athymia and hairlessness. Mice develop largely normal hair follicles and produce hair shafts. However, presumably because of a lack of certain hair keratins, the hair shafts that are generated twist and coil in the hair follicle infundibulum, which becomes dilated. Since hair shafts fail to penetrate the epidermis, macroscopic nudity results and generates the grossly misleading impression that nude mice are hairless. Mice exhibit nude skin phenotype and acute thymic atrophy with a severe early block in thymic epithelial cells (TECs) differentiation. A more severe deterioration seen in medullary thymic epithelial cells (mTECs) than in cortical thymic epithelial cells (cTECs). transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding hair follicle development lymphocyte homeostasis T cell lineage commitment DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development cell proliferation epidermis development regulation of gene expression hemopoiesis cell differentiation keratinocyte differentiation positive regulation of epithelial cell differentiation regulation of T cell differentiation in thymus nail development T cell homeostasis sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter blood vessel morphogenesis thymus development epithelial cell proliferation positive regulation of hair follicle development lymphoid lineage cell migration into thymus thymus epithelium morphogenesis regulation of positive thymic T cell selection uc007kjd.1 uc007kjd.2 uc007kjd.3 uc007kjd.4 
ENSMUST00000108297.3 Pdp1 ENSMUST00000108297.3 pyruvate dehydrogenase phosphatase catalytic subunit 1, transcript variant 3 (from RefSeq NM_001033453.3) ENSMUST00000108297.1 ENSMUST00000108297.2 NM_001033453 PDP1_MOUSE Ppm2c Q3UV70 uc008sab.1 uc008sab.2 uc008sab.3 uc008sab.4 Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA. Reaction=H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate; Xref=Rhea:RHEA:12669, Rhea:RHEA-COMP:13689, Rhea:RHEA- COMP:13690, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.43; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12670; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 Mn(2+) ions per subunit (By similarity). Binds 2 Mg(2+) ions per subunit (By similarity). Mn(2+) can substitute Mg2(+) for catalytic activity (By similarity). Magnesium-dependent and calcium-stimulated (By similarity). PDP1 activity strongly depends on its Ca(2+)-dependent binding to the lipoyl domain of E2 subunit of component of the pyruvate dehydrogenase complex (By similarity). Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit. Mitochondrion Belongs to the PP2C family. magnesium ion binding catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity magnesium-dependent protein serine/threonine phosphatase activity [pyruvate dehydrogenase (lipoamide)] phosphatase activity calcium ion binding mitochondrion mitochondrial matrix protein dephosphorylation hydrolase activity peptidyl-threonine dephosphorylation cation binding macromolecular complex binding metal ion binding positive regulation of pyruvate dehydrogenase activity uc008sab.1 uc008sab.2 uc008sab.3 uc008sab.4 
ENSMUST00000108300.8 Ect2 ENSMUST00000108300.8 ect2 oncogene, transcript variant 1 (from RefSeq NM_007900.4) ECT2_MOUSE ENSMUST00000108300.1 ENSMUST00000108300.2 ENSMUST00000108300.3 ENSMUST00000108300.4 ENSMUST00000108300.5 ENSMUST00000108300.6 ENSMUST00000108300.7 NM_007900 Q07139 Q3TZP2 Q5DTR8 Q80VE4 Q8CIH2 Q8K2A0 Q8R3E2 mKIAA4037 uc008oth.1 uc008oth.2 uc008oth.3 uc008oth.4 Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A- PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. Autoinhibited by the C-terminal PH domain which folds back and binds to the surface of the DH domain, blocking binding of RHOA to the catalytic center of the DH domain. The 2nd BRCT domain is also involved in inhibition, probably by helping to impede RHOA binding. Allosterically activated by binding of activated GTP-bound RHOA to the PH domain which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the catalytic center. Binding of phosphorylated RACGAP1 to the N-terminal BRCT domain-containing region also releases autoinhibition. Homodimer (By similarity). Homooligomer (By similarity). Found in the centralspindlin complex (By similarity). Interacts with NR1I3 (PubMed:17904126). Interacts (Thr-359 phosphorylated form) with PARD6A; the interaction is observed in cancer cells (By similarity). Interacts (Thr-359 phosphorylated form) with PRKCI; the interaction is observed in cancer cells (By similarity). Interacts with PKP4; the interaction is observed at the midbody (By similarity). Interacts with RACGAP1; the interaction is direct, occurs in a microtubule-dependent manner, occurs at anaphase and during cytokinesis, is inhibited in metaphase by phosphorylation of ECT2 on Thr-373 and is stimulated in early anaphase by dephosphorylation of ECT2 probably on Thr-373 through CDK1 activity (By similarity). Interacts with PLK1; the interaction is stimulated upon its phosphorylation on Thr-444 (By similarity). Interacts with RHOA; the interaction results in allosteric activation of ECT2 (By similarity). Interacts with KIF23, PARD3, PARD6B and PRKCQ (By similarity). Interacts with NEDD9/HEF1 (By similarity). Nucleus Cytoplasm Cytoplasm, cytoskeleton, spindle Cleavage furrow Midbody Cell junction Cell junction, tight junction Note=Sequestered within the nucleus during interphase (By similarity). Dispersed throughout the cytoplasm upon breakdown of the nuclear envelope during mitosis (By similarity). Colocalizes with the centralspindlin complex to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis (By similarity). Colocalized with RhoA at the midbody (By similarity). Its subcellular localization to tight junction is increased by calcium (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q07139-1; Sequence=Displayed; Name=2; IsoId=Q07139-2; Sequence=VSP_041981; Name=3; IsoId=Q07139-3; Sequence=VSP_041979, VSP_041980; Highest expression in testis. Also detectable in brain, kidney, liver and spleen. Expressed in the embryo at 16 dpc. Up-regulated by phenobarbital in the nucleus and cytoplasm of the liver. The BRCT domain 1 and 2 are required for the intramolecular interaction, but not for the intermolecular oligomerization. The BRCT domains negatively inhibit its GEF activity in interphase cells. The same BRCT domains may act as a positive regulatory motif for the completion of cytokinesis after the breakdown of nuclear membrane during mitosis (By similarity). Phosphorylated by PLK1 in vitro. Hyperphosphorylated during the G2 phase of the cell cycle. Phosphorylation at Thr-373 occurs during the G2/M phase, relieves its auto-inhibition status and stimulates its GEF activity. Phosphorylation at Thr-444 in G2/M phase is required for subsequent binding with PLK1 and Rho exchange activation. Dephosphorylated at the time of cytokinesis. Phosphorylation at Thr-359 is required for its transformation activity in cancer cells (By similarity). [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=AAA37536.1; Type=Miscellaneous discrepancy; Note=Erroneous CDS prediction.; Evidence=; mitotic cytokinesis cell morphogenesis guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity protein binding nucleus cytoplasm spindle cytosol cytoskeleton cell-cell junction bicellular tight junction cell cycle nervous system development protein transport Rho GTPase binding cell junction cell differentiation midbody activation of protein kinase activity cleavage furrow positive regulation of cytokinesis regulation of Rho protein signal transduction intracellular signal transduction positive regulation of protein import into nucleus protein homodimerization activity positive regulation of apoptotic process positive regulation of GTPase activity positive regulation of neuron differentiation regulation of protein kinase activity protein homooligomerization cell division regulation of attachment of spindle microtubules to kinetochore cellular response to hydrogen peroxide bicellular tight junction assembly cellular response to calcium ion cellular response to ionizing radiation mitotic spindle activation of GTPase activity centralspindlin complex regulation of cytokinesis, actomyosin contractile ring assembly uc008oth.1 uc008oth.2 uc008oth.3 uc008oth.4 
ENSMUST00000108304.9 Gem ENSMUST00000108304.9 GTP binding protein overexpressed in skeletal muscle (from RefSeq NM_010276.4) ENSMUST00000108304.1 ENSMUST00000108304.2 ENSMUST00000108304.3 ENSMUST00000108304.4 ENSMUST00000108304.5 ENSMUST00000108304.6 ENSMUST00000108304.7 ENSMUST00000108304.8 Gem NM_010276 Q3TH76 Q3TH76_MOUSE uc008rzv.1 uc008rzv.2 uc008rzv.3 uc008rzv.4 Interacts with Calmodulin. Belongs to the small GTPase superfamily. RGK family. nucleotide binding mitotic cell cycle magnesium ion binding GTPase activity GTP binding signal transduction cytoplasmic side of plasma membrane membrane GDP binding midbody spindle midzone chromosome organization metaphase plate congression mitotic spindle negative regulation of high voltage-gated calcium channel activity uc008rzv.1 uc008rzv.2 uc008rzv.3 uc008rzv.4 
ENSMUST00000108311.9 Esrp1 ENSMUST00000108311.9 epithelial splicing regulatory protein 1, transcript variant 1 (from RefSeq NM_194055.3) ENSMUST00000108311.1 ENSMUST00000108311.2 ENSMUST00000108311.3 ENSMUST00000108311.4 ENSMUST00000108311.5 ENSMUST00000108311.6 ENSMUST00000108311.7 ENSMUST00000108311.8 Esrp1 F8WGU3 F8WGU3_MOUSE NM_194055 uc012dao.1 uc012dao.2 uc012dao.3 uc012dao.4 Nucleus Belongs to the ESRP family. nucleic acid binding RNA binding mRNA binding nucleus nucleoplasm nuclear body regulation of RNA splicing uc012dao.1 uc012dao.2 uc012dao.3 uc012dao.4 
ENSMUST00000108315.4 Dll3 ENSMUST00000108315.4 delta like canonical Notch ligand 3 (from RefSeq NM_007866.2) Dll3 ENSMUST00000108315.1 ENSMUST00000108315.2 ENSMUST00000108315.3 NM_007866 Q3UND5 Q3UND5_MOUSE uc009fye.1 uc009fye.2 uc009fye.3 Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. skeletal system development calcium ion binding membrane integral component of membrane uc009fye.1 uc009fye.2 uc009fye.3 
ENSMUST00000108336.8 Zfp60 ENSMUST00000108336.8 zinc finger protein 60, transcript variant 2 (from RefSeq NM_029531.2) ENSMUST00000108336.1 ENSMUST00000108336.2 ENSMUST00000108336.3 ENSMUST00000108336.4 ENSMUST00000108336.5 ENSMUST00000108336.6 ENSMUST00000108336.7 NM_029531 Q8K0D9 Q8K0D9_MOUSE Zfp60 uc009fxa.1 uc009fxa.2 uc009fxa.3 Nucleus nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009fxa.1 uc009fxa.2 uc009fxa.3 
ENSMUST00000108344.9 Akt2 ENSMUST00000108344.9 thymoma viral proto-oncogene 2, transcript variant 3 (from RefSeq NM_001331108.1) AKT2_MOUSE ENSMUST00000108344.1 ENSMUST00000108344.2 ENSMUST00000108344.3 ENSMUST00000108344.4 ENSMUST00000108344.5 ENSMUST00000108344.6 ENSMUST00000108344.7 ENSMUST00000108344.8 NM_001331108 Q60823 uc009fwr.1 uc009fwr.2 uc009fwr.3 uc009fwr.4 AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinases, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E- BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF- kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P- 5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet- derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Involved in the inhibition of ciliogenesis associated with RAB8-dependent cilia growth (By similarity). One of the few specific substrates of AKT2 identified so far is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on 'Ser-197' during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Phosphorylates CLK2 on 'Thr-343'. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Two specific sites, one in the kinase domain (Thr- 309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation. Interacts (via PH domain) with MTCP1, TCL1A and TCL1B. Interacts with CLK2, PBH2 and TRAF6. Interacts (when phosphorylated) with CLIP3, the interaction promotes cell membrane localization (By similarity). Interacts with BTBD10 (PubMed:18160256). Interacts with KCTD20 (PubMed:24156551). Interacts with WDFY2 (via WD repeats 1-3) (PubMed:16792529, PubMed:20189988). Cytoplasm Nucleus Cell membrane ; Peripheral membrane protein Early endosome Note=Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N- terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. Colocalizes with WDFY2 in early endosomes (PubMed:20189988). Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PIK3CA) results in its targeting to the plasma membrane. Phosphorylation on Thr-309 and Ser-474 is required for full activity. Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. TRAF6-induced 'Lys-63'-linked AKT2 ubiquitination. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome (By similarity). O-GlcNAcylation at Thr-306 and Thr-313 inhibits activating phosphorylation at Thr-309 via disrupting the interaction between AKT and PDK1. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. In light of strong homologies in the primary amino acid sequence, the 3 AKT kinases were long surmised to play redundant and overlapping roles. More recent studies has brought into question the redundancy within AKT kinase isoforms and instead pointed to isoform specific functions in different cellular events and diseases. AKT1 is more specifically involved in cellular survival pathways, by inhibiting apoptotic processes; whereas AKT2 is more specific for the insulin receptor signaling pathway. Moreover, while AKT1 and AKT2 are often implicated in many aspects of cellular transformation, the 2 isoforms act in a complementary opposing manner. The role of AKT3 is less clear, though it appears to be predominantly expressed in brain. nucleotide binding positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity protein kinase C binding protein binding ATP binding nucleus cytoplasm mitochondrion endosome early endosome cytosol plasma membrane cell cortex carbohydrate metabolic process glycogen metabolic process glycogen biosynthetic process glucose metabolic process regulation of translation protein phosphorylation apoptotic process multicellular organism development positive regulation of cell proliferation insulin receptor signaling pathway carbohydrate transport positive regulation of signal transduction positive regulation of gene expression negative regulation of plasma membrane long-chain fatty acid transport positive regulation of sodium ion transport positive regulation of glucose metabolic process positive regulation of mitochondrial membrane potential membrane kinase activity phosphorylation sarcoplasmic reticulum transferase activity peptidyl-serine phosphorylation positive regulation of cell migration positive regulation of vesicle fusion vesicle positive regulation of fatty acid beta-oxidation peripheral nervous system myelin maintenance ruffle membrane insulin-responsive compartment response to insulin cellular response to insulin stimulus macromolecular complex negative regulation of RNA splicing positive regulation of peptidyl-serine phosphorylation intracellular signal transduction negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process intracellular membrane-bounded organelle protein kinase B signaling positive regulation of nitric oxide biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import metal ion binding positive regulation of positive chemotaxis intracellular protein transmembrane transport cellular response to organic cyclic compound cellular response to high light intensity protein localization to plasma membrane positive regulation of protein targeting to membrane activation of GTPase activity retinal rod cell apoptotic process positive regulation of cell motility uc009fwr.1 uc009fwr.2 uc009fwr.3 uc009fwr.4 
ENSMUST00000108345.9 Ythdf3 ENSMUST00000108345.9 YTH N6-methyladenosine RNA binding protein 3, transcript variant 5 (from RefSeq NM_001358043.1) ENSMUST00000108345.1 ENSMUST00000108345.2 ENSMUST00000108345.3 ENSMUST00000108345.4 ENSMUST00000108345.5 ENSMUST00000108345.6 ENSMUST00000108345.7 ENSMUST00000108345.8 NM_001358043 Q3UVI5 Q6NXJ6 Q6NXJ8 Q8BKB6 Q8BYK6 YTHD3_MOUSE Ythdf3 uc008ori.1 uc008ori.2 uc008ori.3 uc008ori.4 uc008ori.5 Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, and regulates their stability (PubMed:32905781, PubMed:32943573). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:32943573). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 (PubMed:32943573, PubMed:32905781). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:32943573). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (PubMed:30591559). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (PubMed:30591559). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (By similarity). Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (By similarity). Promotes formation of phase-separated membraneless compartments, such as P- bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (By similarity). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (By similarity). May also recognize and bind N1- methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (By similarity). Interacts with CNOT1; promoting recruitment of the CCR4-NOT complex (By similarity). Interacts with YTHDF1 (By similarity). Interacts with YTHDF2 (By similarity). Interacts with PAN3 (PubMed:32905781). Cytoplasm, cytosol Cytoplasm, P-body Cytoplasm, Stress granule Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BYK6-1; Sequence=Displayed; Name=2; IsoId=Q8BYK6-2; Sequence=VSP_017833; Name=3; IsoId=Q8BYK6-3; Sequence=VSP_017834; The disordered regions have the ability to interact with each other and to 'phase separate' into liquid droplets within the cytosol following binding to mRNAs containing multiple m6A-modified residues. This leads to the partition of m6A-containing mRNAs into membraneless compartments, where mRNAs may be stored, degraded or used to transport mRNAs to dendritic arbors in neurons. Mice are viable and normal in size but display increased interferon-stimulated genes (ISGs) levels and are resistant to several viral infections (PubMed:30591559). Mice lacking Ythdf1, Ythdf2 and Ythdf3 display early embryonic lethality and show defects in embryonic stem cell differentiation (PubMed:32943573). Belongs to the YTHDF family. YTHDF3 subfamily. Was initially reported to act as a regulator of mRNA translation efficiency by binding to m6A-containing mRNAs (PubMed:30591559). This study suggested that the 3 different paralogs (YTHDF1, YTHDF2 and YTHDF3) have unique functions with limited redundancy (PubMed:32943573). However, later studies showed that YTHDF1, YTHDF2 and YTHDF3 paralogs have redundant functions to a profound extent and directly promote degradation of m6A-containing mRNAs (PubMed:32943573). The effect on translation efficiency observed earlier is probably indirect (PubMed:32943573). RNA binding cellular_component cytoplasm cytosol ribosome binding positive regulation of translation positive regulation of translational initiation negative regulation of type I interferon-mediated signaling pathway mRNA destabilization N6-methyladenosine-containing RNA binding uc008ori.1 uc008ori.2 uc008ori.3 uc008ori.4 uc008ori.5 
ENSMUST00000108352.9 Sirpb1c ENSMUST00000108352.9 Sirpb1c (from geneSymbol) AK054545 ENSMUST00000108352.1 ENSMUST00000108352.2 ENSMUST00000108352.3 ENSMUST00000108352.4 ENSMUST00000108352.5 ENSMUST00000108352.6 ENSMUST00000108352.7 ENSMUST00000108352.8 K7N6K7 K7N6K7_MOUSE Sirpb1c uc008ore.1 uc008ore.2 uc008ore.3 uc008ore.4 uc008ore.5 uc008ore.6 molecular_function plasma membrane membrane integral component of membrane positive regulation of cell-cell adhesion positive regulation of phagocytosis positive regulation of T cell activation uc008ore.1 uc008ore.2 uc008ore.3 uc008ore.4 uc008ore.5 uc008ore.6 
ENSMUST00000108353.9 Hipk4 ENSMUST00000108353.9 homeodomain interacting protein kinase 4 (from RefSeq NM_001033315.2) A8R3X8 B9EJV5 ENSMUST00000108353.1 ENSMUST00000108353.2 ENSMUST00000108353.3 ENSMUST00000108353.4 ENSMUST00000108353.5 ENSMUST00000108353.6 ENSMUST00000108353.7 ENSMUST00000108353.8 Gm162 HIPK4_MOUSE NM_001033315 Q3V016 uc012fgj.1 uc012fgj.2 uc012fgj.3 uc012fgj.4 Protein kinase that phosphorylates murine TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter. May act as a corepressor of transcription factors (Potential). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3V016-1; Sequence=Displayed; Name=2; IsoId=Q3V016-2; Sequence=VSP_023035; Expressed at moderate levels in lung and white adipose tissues and weakly in brain and liver. Autophosphorylated. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation histone phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation protein autophosphorylation regulation of signal transduction by p53 class mediator uc012fgj.1 uc012fgj.2 uc012fgj.3 uc012fgj.4 
ENSMUST00000108355.2 Prx ENSMUST00000108355.2 periaxin, transcript variant 2 (from RefSeq NM_019412.2) ENSMUST00000108355.1 NM_019412 O55103 O55104 PRAX_MOUSE uc009fwj.1 uc009fwj.2 uc009fwj.3 uc009fwj.4 Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells (PubMed:11430802, PubMed:21745462, PubMed:22764250). Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli (PubMed:10839370). Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions (PubMed:15356632). Required for normal remyelination after nerve injury (PubMed:10839370). Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses (PubMed:15356632, PubMed:23022068). Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions (PubMed:15356632, PubMed:23022068). Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves (PubMed:23022068, PubMed:22764250). Recruits DRP2 to the Schwann cell plasma membrane (PubMed:11430802, PubMed:23022068, PubMed:22764250). Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology (PubMed:21745462). Homodimer (via PDZ domain) (By similarity). Interacts with SCN10A. Found in a complex with SCN10A (By similarity). Interacts with DRP2 (PubMed:22764250). Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (PubMed:11430802). Detected in a complex composed of at least EZR, AHNAK, PPL and PRX (By similarity). Identified in a complex with EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, VIM and spectrin (PubMed:21745462). Cell membrane Cell junction Note=Colocalizes with ACTB at tricellular junctions between eye lens fiber cells. [Isoform 1]: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus Cytoplasm Note=Detected in the Schwann cell nucleus prior to the onset of myelination (PubMed:10671475). Detected in Schwann cells at periaxonal myelin membranes. Associated with the cell membrane during myelination (PubMed:9488714). [Isoform 2]: Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=L-periaxin; IsoId=O55103-1; Sequence=Displayed; Name=2; Synonyms=S-periaxin; IsoId=O55103-2; Sequence=VSP_004366, VSP_004367; Detected in myelinating Schwann cells in intramuscular nerves in triangularis sterni (PubMed:18205176). Detected in sciatic nerve (PubMed:11430802). Detected in eye lens fiber cells (PubMed:21745462). Isoform 1 is detected in myelinating Schwann cells in sciatic nerve (PubMed:9488714, PubMed:10671475, PubMed:10839370). Isoform 2 is detected in myelinating Schwann cells in sciatic nerve (at protein level) (PubMed:9488714, PubMed:10839370). Detected in sciatic nerve (PubMed:9488714, PubMed:10839370). Detected in embryonic eye lens; levels increase steadily from 10.5 dpc onto birth and continue to increase during the first three weeks after birth. Has a remarkable domain of repetitive pentameric units sometimes followed by a tripeptide spacer, it may separate two functional basic and acidic domains. The PDZ domain contains the signal for export from the nucleus (By similarity). The N-terminal region including the PDZ domain is required for the formation of Cajal bands on myelinated nerves. The Arg/Lys-rich basic domain functions as a tripartite nuclear localization signal. Mice are born at the expected Mendelian rate and appear grossly normal during the first six weeks of life. After six to nine months, they display pronounced unsteadiness of gait and difficulty in supporting themselves on their hindlimbs, weight loss due to an inability to feed and labored respiration (PubMed:10839370). Their sensory, motor and vagus nerves show extensive demyelination with demyelinated segments surrounded by focal thickenings (PubMed:10839370, PubMed:18205176). In contrast, the predominantly sensory saphenous nerves are extensively hypermyelinated, resulting in myelin sheath infolding and axon compression (PubMed:10839370). At eight months, naked or thinly myelinated axons are common in sciatic nerve fibers (PubMed:10839370). Already at six weeks, mutant mice display markedly increased sensitivity to noxious mechanical and thermal stimuli (PubMed:10839370). Besides, four month old mutant mice display impaired remyelination after crush injury (PubMed:10839370). Schwann cells from mutant mice display a reduced rate of elongation, leading to decreased distances between nodes of Ranvier and reduced velocity of the transmission of nerve impulses; this results in impaired motor skills on the RotaRod in three week old mice (PubMed:15356632). Peripheral nerves show decreased conduction velocity, due to defects in the myelin sheath (PubMed:10839370). Motor axons from five month old mice show an increased number of preterminal branches that arise from demyelinated regions close to the neuromuscular junction (PubMed:18205176). In contrast, axon branching close to the neuromuscular junction appears normal in three week old mice (PubMed:18205176). At the molecular level, gene disruption impairs formation of Cajal bands and location of Drp2 in patches that colocalize with appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane (PubMed:15356632). Cytoplasm from mutant Schwann cells forms a concentric ring under the cell membrane, instead of being strictly compartmentalized at Cajal bands (PubMed:15356632). The transport of the mRNA coding for Mbp is impaired; the mRNA level is highest in the perinuclear region and does not accumulate in the paranodal region (PubMed:15356632). Eye lenses from 90 day old mutant mice appear grossly normal at the macroscopic level, but display altered shape and organization of inner lens fiber cells, together with alteration in the membrane localization of Mip, Ezr and Ahnak (PubMed:21745462). Belongs to the periaxin family. nucleus cytoplasm cytosol plasma membrane membrane transmission of nerve impulse sensory perception of pain cell junction T-tubule peripheral nervous system myelin maintenance peripheral nervous system myelin formation myelin sheath regulation of RNA splicing uc009fwj.1 uc009fwj.2 uc009fwj.3 uc009fwj.4 
ENSMUST00000108361.2 Sirpd ENSMUST00000108361.2 signal regulatory protein delta (from RefSeq NM_001076679.2) 751864 ENSMUST00000108361.1 Gm9733 NM_001076679 Q1AN91 Q1AN91_MOUSE Sirpd uc008oqv.1 uc008oqv.2 molecular_function plasma membrane biological_process uc008oqv.1 uc008oqv.2 
ENSMUST00000108383.2 Sdr16c6 ENSMUST00000108383.2 short chain dehydrogenase/reductase family 16C, member 6 (from RefSeq NM_001080710.2) ENSMUST00000108383.1 NM_001080710 Q05A13 S16C6_MOUSE uc008rwy.1 uc008rwy.2 uc008rwy.3 uc008rwy.4 Belongs to the short-chain dehydrogenases/reductases (SDR) family. molecular_function lipid particle biological_process oxidoreductase activity oxidation-reduction process uc008rwy.1 uc008rwy.2 uc008rwy.3 uc008rwy.4 
ENSMUST00000108385.3 Cyp2t4 ENSMUST00000108385.3 Belongs to the cytochrome P450 family. (from UniProt D3Z7F6) Cyp2t4 D3Z7F6 D3Z7F6_MOUSE ENSMUST00000108385.1 ENSMUST00000108385.2 uc291ndp.1 uc291ndp.2 Belongs to the cytochrome P450 family. iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding exogenous drug catabolic process intracellular membrane-bounded organelle oxidation-reduction process uc291ndp.1 uc291ndp.2 
ENSMUST00000108387.9 Nlrp9a ENSMUST00000108387.9 NLR family, pyrin domain containing 9A, transcript variant 3 (from RefSeq NM_001302792.1) D3Z7F5 D3Z7F5_MOUSE ENSMUST00000108387.1 ENSMUST00000108387.2 ENSMUST00000108387.3 ENSMUST00000108387.4 ENSMUST00000108387.5 ENSMUST00000108387.6 ENSMUST00000108387.7 ENSMUST00000108387.8 NM_001302792 Nlrp9a uc009fuo.1 uc009fuo.2 uc009fuo.3 uc009fuo.4 Belongs to the NLRP family. nucleotide binding ATP binding uc009fuo.1 uc009fuo.2 uc009fuo.3 uc009fuo.4 
ENSMUST00000108394.4 Hnf4g ENSMUST00000108394.4 hepatocyte nuclear factor 4, gamma, transcript variant 1 (from RefSeq NM_001395870.1) E9QPS1 E9QPS1_MOUSE ENSMUST00000108394.1 ENSMUST00000108394.2 ENSMUST00000108394.3 Hnf4g NM_001395870 uc290dru.1 uc290dru.2 uc290dru.3 Nucleus Belongs to the nuclear hormone receptor family. NR2 subfamily. DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity nucleus regulation of transcription, DNA-templated zinc ion binding steroid hormone mediated signaling pathway sequence-specific DNA binding metal ion binding uc290dru.1 uc290dru.2 uc290dru.3 
ENSMUST00000108400.8 Efcab5 ENSMUST00000108400.8 EF-hand calcium binding domain 5 (from RefSeq NM_176965.4) A0JP43 B0QZJ9 EFCB5_MOUSE ENSMUST00000108400.1 ENSMUST00000108400.2 ENSMUST00000108400.3 ENSMUST00000108400.4 ENSMUST00000108400.5 ENSMUST00000108400.6 ENSMUST00000108400.7 NM_176965 Q5NC53 Q8CBN1 Q8CDP1 uc007kgj.1 uc007kgj.2 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A0JP43-1; Sequence=Displayed; Name=2; IsoId=A0JP43-2; Sequence=VSP_030736, VSP_030737; Name=3; IsoId=A0JP43-3; Sequence=VSP_030738; Sequence=BAC26618.1; Type=Frameshift; Evidence=; Sequence=BAC29157.1; Type=Frameshift; Evidence=; molecular_function calcium ion binding cellular_component biological_process metal ion binding uc007kgj.1 uc007kgj.2 
ENSMUST00000108402.9 Slc6a4 ENSMUST00000108402.9 Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:9037532, PubMed:9547354) (By similarity). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (PubMed:25600870, PubMed:9547354). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (PubMed:27111230). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:9037532, PubMed:9547354) (By similarity). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). (from UniProt Q60857) AF013604 ENSMUST00000108402.1 ENSMUST00000108402.2 ENSMUST00000108402.3 ENSMUST00000108402.4 ENSMUST00000108402.5 ENSMUST00000108402.6 ENSMUST00000108402.7 ENSMUST00000108402.8 Htt O35241 Q5NCR6 Q60857 SC6A4_MOUSE Sert Slc6a4 uc288aiv.1 uc288aiv.2 Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:9037532, PubMed:9547354) (By similarity). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (PubMed:25600870, PubMed:9547354). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (PubMed:27111230). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:9037532, PubMed:9547354) (By similarity). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). Reaction=H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out) = H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in); Xref=Rhea:RHEA:75839, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:350546; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75840; Evidence=; Kinetic parameters: KM=403 nM for serotonin ; Vmax=1.02 pmol/min/mg enzyme for serotonin ; Monomer or homooligomer (By similarity). Interacts (via C- terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with filamentous actin and STX1A (By similarity). Interacts (via the N-terminus) with STX1A (via the H3 domain); this interaction regulates SLC4A6 channel conductance (By similarity). Interacts with SEC23A, SEC24C and PATJ. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake (PubMed:17452640). Interacts with TGFB1I1 (PubMed:16803896). Interacts with ITGAV:ITGB3 (PubMed:29038237). Interacts (via C-terminus) with ITGB3; this interaction regulates SLC6A4 trafficking (By similarity). Q60857; Q9Z0J4: Nos1; NbExp=4; IntAct=EBI-15633326, EBI-397596; Cell membrane ; Multi-pass membrane protein Endomembrane system ; Multi-pass membrane protein Endosome membrane ; Multi- pass membrane protein Synapse Cell junction, focal adhesion Cell projection, neuron projection Note=Could be part of recycling endosomes. Density of transporter molecules on the plasma membrane is itself regulated by STX1A. Density of transporter molecules on the plasma membrane is also regulated by serotonin (By similarity). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (PubMed:29038237). Expressed in the lung, midbrain and brainstem regions (PubMed:9037532). Expressed in brainstem raphe neurons (PubMed:25600870). Expressed in the uncrossed ipsilateral retinal ganglion cells (iRGCs) of the peripheral ventrotemporal (VT) region segment in the retina at 16.5 dpc (PubMed:20676059). Expressed during early postnatal brain development in neurons of brainstem and ventrobasal complex (VB) nuclei, including thalamic VB, dorso-lateral geniculate (DLG) nucleus neurons and hippocampal neurons. Expressed in the somatosensory cortex and the brainstem at postnatal day 7 (at protein level) (PubMed:25600870). Expressed in a circadian manner in the midbrain with a higher level expression seen during the dark phase (at protein level). Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation. Mutant mice are born at the expected Mendelian rate. Knockdown results in loss of serotonin uptake in synaptosomes of brainstem and cortex, abnormal barrel cortex development, enteric nervous system hyperplasia and reduced peristaltic reflexes. This protein is the target of psychomotor stimulants such as amphetamines or cocaine. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. Sequence=X66119; Type=Frameshift; Evidence=; response to hypoxia neurotransmitter:sodium symporter activity serotonin:sodium symporter activity protein binding endosome plasma membrane integral component of plasma membrane focal adhesion neurotransmitter transport serotonin transport brain development response to nutrient memory circadian rhythm monoamine transmembrane transporter activity response to toxic substance endosome membrane response to organic substance positive regulation of gene expression endomembrane system positive regulation of serotonin secretion symporter activity monoamine transport membrane integral component of membrane myosin binding syntaxin-1 binding Rab GTPase binding cocaine binding negative regulation of cerebellar granule cell precursor proliferation cell junction negative regulation of synaptic transmission, dopaminergic response to estradiol social behavior vasoconstriction response to drug sperm ejaculation protein homodimerization activity neuron projection membrane raft synapse negative regulation of neuron differentiation positive regulation of cell cycle negative regulation of organ growth metal ion binding brain morphogenesis nitric-oxide synthase binding actin filament binding protein oligomerization protein homooligomerization serotonin binding serotonin uptake transmembrane transport cellular response to retinoic acid cellular response to organic substance cellular response to cGMP regulation of thalamus size neurotransmitter reuptake integral component of postsynaptic membrane integral component of presynaptic membrane uc288aiv.1 uc288aiv.2 
ENSMUST00000108409.2 Tmem145 ENSMUST00000108409.2 transmembrane protein 145, transcript variant 5 (from RefSeq NR_175363.1) E9PUE6 E9PUE6_MOUSE ENSMUST00000108409.1 NR_175363 Tmem145 uc009fsi.1 uc009fsi.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor signaling pathway membrane integral component of membrane response to pheromone uc009fsi.1 uc009fsi.2 
ENSMUST00000108415.10 Pou2f2 ENSMUST00000108415.10 POU domain, class 2, transcription factor 2, transcript variant 2 (from RefSeq NM_011138.3) ENSMUST00000108415.1 ENSMUST00000108415.2 ENSMUST00000108415.3 ENSMUST00000108415.4 ENSMUST00000108415.5 ENSMUST00000108415.6 ENSMUST00000108415.7 ENSMUST00000108415.8 ENSMUST00000108415.9 NM_011138 Oct2 Otf2 PO2F2_MOUSE Pou2f2 Q00196 Q00197 Q00198 Q00199 Q00200 Q00201 Q05882 Q3KR47 Q3U127 Q5XML1 Q5XML2 Q61995 Q61996 Q64245 uc009frn.1 uc009frn.2 uc009frn.3 uc009frn.4 uc009frn.5 Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2011512, PubMed:1281152). Regulates IL6 expression in B cells with POU2AF1 (PubMed:23045607). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. [Isoform OCT2.1]: Activates octamer-containing promoters. [Isoform OCT2.2]: Activates octamer-containing promoters. [Isoform OCT2.3]: Activates octamer-containing promoters. [Isoform OCT2.4]: Represses some promoters and activate others. [Isoform OCT2.5]: Represses some promoters and activate others (PubMed:1281152, PubMed:2011512). Activates the U2 small nuclear RNA (snRNA) promoter (By similarity). [Isoform OCT2.7]: Unable to bind to the octamer motif, but can still activate the beta-casein gene promoter at low levels. Transactivation activity is enhanced by transcriptional coactivator POU2AF1. Interacts with NR3C1, AR and PGR. Interacts with POU2AF1; the interaction increases POU2F2 transactivation activity. Cytoplasm Nucleus te=In alveolus epithelial cells of mammary glands, present in the nucleus and cytoplasm. In HC11 mammary epithelial cells, present in the nucleus and preinuclear regions. Event=Alternative splicing; Named isoforms=7; Comment=Additional isoforms seem to exist.; Name=OCT2.1; Synonyms=Major form; IsoId=Q00196-1; Sequence=Displayed; Name=OCT2.2; Synonyms=OCT2a; IsoId=Q00196-2; Sequence=VSP_002328; Name=OCT2.3; IsoId=Q00196-3; Sequence=VSP_002326; Name=OCT2.4; IsoId=Q00196-4; Sequence=VSP_002329, VSP_002330; Name=OCT2.5; Synonyms=OCT2b; IsoId=Q00196-5; Sequence=VSP_002331; Name=OCT2.6; IsoId=Q00196-6; Sequence=VSP_002327; Name=OCT2.7; IsoId=Q00196-7; Sequence=VSP_002326, VSP_032188; Highest in B cells, but also present in brain (neuronal and glial cells), intestine, kidney, and testes. [Isoform OCT2.1]: Expressed at higher levels in B- cells than in neuronal cells. [Isoform OCT2.2]: Expressed in neuronal cell lines and brain, but not dorsal root ganglia. [Isoform OCT2.3]: Expressed at lower levels in neuronal cells than in B cells. [Isoform OCT2.4]: Expressed in neuronal cell lines, and at lower levels in neuroblastoma and dorsal root ganglia. [Isoform OCT2.5]: Widely expressed in the developing nervous system but expression is confined to very specific regions in the adult brain, it is expressed at a lower level in B cells. [Isoform OCT2.6]: Either absent in, or expressed at very low levels in neuronal cells and brain. [Isoform OCT2.7]: Expressed in all tissues tested: mammary gland, liver, spleen, lung, kidney intestine, uterus and ovary of a virgin mouse. Levels of isoform OCT2.7 are highest in spleen and lung. In mammary gland, expression is localized to the alveolus epithelial cells. Widely but not homogeneously expressed in developing nervous system. Expression levels in mammary glands are barely detectable in virgin mice, levels increase during pregnancy, reaching a maximum during late pregnancy, then decrease during lactation becoming very low post-lactation. In B cells, expression is highly increased upon activation by LPS or CpG. Mutants show normal development of germinal center B cells when infected by influenza virus. [Isoform OCT2.2]: The isoform OCT2b described in PubMed:7888080 corresponds to the isoform OCT2a of PubMed:1976089. To avoid any confusion, we use the nomenclature from PubMed:2011512 to describe the different isoforms. [Isoform OCT2.5]: The isoform OCT2b described in PubMed:7888080 corresponds to the isoform OCT2a of PubMed:1976089. To avoid any confusion, we use the nomenclature from PubMed:2011512 to describe the different isoforms. Belongs to the POU transcription factor family. Class-2 subfamily. Sequence=AAU95617.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE33673.1; Type=Frameshift; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding mature B cell differentiation immunoglobulin secretion involved in immune response DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated protein domain specific binding intracellular membrane-bounded organelle sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter immunoglobulin secretion cell maturation uc009frn.1 uc009frn.2 uc009frn.3 uc009frn.4 uc009frn.5 
ENSMUST00000108430.10 Rps19 ENSMUST00000108430.10 ribosomal protein S19, transcript variant 9 (from RefSeq NR_153409.1) ENSMUST00000108430.1 ENSMUST00000108430.2 ENSMUST00000108430.3 ENSMUST00000108430.4 ENSMUST00000108430.5 ENSMUST00000108430.6 ENSMUST00000108430.7 ENSMUST00000108430.8 ENSMUST00000108430.9 NR_153409 Q5M9J4 Q9CZX8 RS19_MOUSE uc009fqq.1 uc009fqq.2 uc009fqq.3 Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Required for pre- rRNA processing and maturation of 40S ribosomal subunits (By similarity). Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Component of the small ribosomal subunit (PubMed:36517592). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Interacts with RPS19BP1 (PubMed:16289379). Cytoplasm Nucleus, nucleolus Belongs to the eukaryotic ribosomal protein eS19 family. ribosomal small subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) monocyte chemotaxis structural constituent of ribosome nucleoplasm nucleolus cytoplasm cytosol ribosome rRNA processing translation nucleolus organization Notch signaling pathway postsynaptic density fibroblast growth factor binding protein kinase binding cytosolic small ribosomal subunit erythrocyte differentiation maturation of SSU-rRNA translation initiation factor binding killing of cells of other organism ribosomal small subunit biogenesis protein homodimerization activity synapse defense response to Gram-negative bacterium protein tetramerization positive regulation of respiratory burst involved in inflammatory response negative regulation of respiratory burst involved in inflammatory response uc009fqq.1 uc009fqq.2 uc009fqq.3 
ENSMUST00000108431.3 Myo1c ENSMUST00000108431.3 myosin IC, transcript variant 1 (from RefSeq NM_001080775.2) ENSMUST00000108431.1 ENSMUST00000108431.2 MYO1C_MOUSE NM_001080775 O08571 O08834 Q3TBQ4 Q3U231 Q5ND46 Q5ND48 Q5ND49 Q9ERB6 Q9QW54 Q9WTI7 uc007kep.1 uc007kep.2 uc007kep.3 uc007kep.4 This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The protein functions in intracellular vesicle transport to the plasma membrane. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which then are moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4- containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent (PubMed:17994197). Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and CALM (PubMed:15976448). Interacts with POLR1A (PubMed:16514417). Interacts with POLR2A (PubMed:11030652, PubMed:16960872). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (PubMed:16514417). Interacts (via its IQ motifs) with CALM; this precludes interaction with YWHAB (By similarity). Interacts with YWHAB; this precludes interaction with CALM (By similarity). Interacts with RPS6 (By similarity). Interacts with actin (By similarity). Interacts with LLPH (PubMed:26961175). Interacts with GLUT4 (PubMed:22918957). Interacts (via its IQ motifs) with SH3BGRL3; the interaction is dependent on calcium and takes place at membrane ruffles (By similarity). Q9WTI7; Q9QYE9-1: Plekhb1; NbExp=4; IntAct=EBI-777558, EBI-1127141; Q9WTI7; Q9QYE9-2: Plekhb1; NbExp=2; IntAct=EBI-777558, EBI-1127145; Q9WTI7-2; P62158: CALM3; Xeno; NbExp=9; IntAct=EBI-16129068, EBI-397435; Cytoplasm cleus Cytoplasm, cell cortex ll projection, stereocilium membrane Cytoplasmic vesicle Cell projection, ruffle membrane Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane (PubMed:17994197). Colocalizes in adipocytes with GLUT4 at actin-based membranes (PubMed:12490950). Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane (PubMed:22918957). Localizes transiently at cell membrane to region known to be enriched in PIP2 (PubMed:16492791). Activation of phospholipase C results in its redistribution to the cytoplasm (PubMed:16492791). Colocalizes with RNA polymerase II (By similarity). Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription (By similarity). [Isoform 3]: Nucleus, nucleolus cleus, nucleoplasm Note=Colocalizes with RNA polymerase II in the nucleus (PubMed:11030652). Colocalizes with RNA polymerase I in nucleoli (PubMed:16514417). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC) (By similarity). Accumulates strongly in DFC and GC during activation of transcription (By similarity). Colocalizes with transcription sites (PubMed:16514417). Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6 (By similarity). Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles (By similarity). Colocalizes with RPS6 at the nuclear pore level (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9WTI7-1; Sequence=Displayed; Name=2; Synonyms=A; IsoId=Q9WTI7-2; Sequence=VSP_036863; Name=3; Synonyms=Nuclear myosin 1, NM1; IsoId=Q9WTI7-3; Sequence=VSP_036864; Name=4; Synonyms=B; IsoId=Q9WTI7-4; Sequence=VSP_003350; Isoform 3 is expressed in small intestine, pancreas, brain, kidney, skin, heart muscle, testis, striated muscle, spleen, liver and lung (at protein level). Expressed in brain, testis, adrenal glands, thymus, spleen, kidney, lung, heart, cochlea and vestibule. Expressed in sensory hair cells of the inner ear. Expressed in adipocytes. Up-regulated by serum. Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5- trisphosphate (InsP3). The PIP2-binding site corresponds to the myosin tail domain (PH-like) present in its tail domain. Isoform 2 contains a N-acetylmethionine at position 1. [Isoform 4]: May be due to a frameshift. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1). microfilament motor activity nucleotide binding ruffle motor activity actin binding receptor binding protein binding calmodulin binding ATP binding phospholipid binding nucleus nuclear pore nucleoplasm nucleolus cytoplasm cytosol plasma membrane microvillus brush border protein targeting protein targeting to membrane protein C-terminus binding basal plasma membrane protein transport membrane lateral plasma membrane myosin complex nuclear body Ral GTPase binding vesicle transport along actin filament positive regulation of cell migration cytoplasmic vesicle membrane positive regulation of actin filament polymerization actin-dependent ATPase activity cytoplasmic vesicle filamentous actin stereocilium stereocilium bundle ruffle membrane positive regulation of cell migration by vascular endothelial growth factor signaling pathway cell projection membrane raft phagocytic vesicle actin filament binding mRNA transport stereocilium membrane cellular response to interferon-gamma positive regulation of protein targeting to membrane positive regulation of cellular response to insulin stimulus positive regulation of vascular endothelial growth factor signaling pathway regulation of bicellular tight junction assembly uc007kep.1 uc007kep.2 uc007kep.3 uc007kep.4 
ENSMUST00000108438.10 Zfp93 ENSMUST00000108438.10 zinc finger protein 93, transcript variant 2 (from RefSeq NM_009567.4) ENSMUST00000108438.1 ENSMUST00000108438.2 ENSMUST00000108438.3 ENSMUST00000108438.4 ENSMUST00000108438.5 ENSMUST00000108438.6 ENSMUST00000108438.7 ENSMUST00000108438.8 ENSMUST00000108438.9 NM_009567 Q3UKA3 Q61116 Q8CE70 ZN235_MOUSE Znf235 uc009fpe.1 uc009fpe.2 uc009fpe.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009fpe.1 uc009fpe.2 uc009fpe.3 
ENSMUST00000108453.2 Zfp296 ENSMUST00000108453.2 zinc finger protein 296 (from RefSeq NM_022409.2) E9Q6W4 ENSMUST00000108453.1 NM_022409 Q4FZI6 Q9D7X0 Q9EPM0 ZN296_MOUSE Zfp296 Znf296 uc009fmj.1 uc009fmj.2 uc009fmj.3 May be a transcriptional corepressor with KLF4. Interacts with KLF4. Nucleus Strongly expressed in testis and embryonic stem cells. In testis, detected in condensing spermatids but not at earlier stages of spermatogenesis (PubMed:11063263). In embryonic stem cells, expressed in undifferentiated cells and down- regulated upon differentiation (PubMed:24161396). Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAN76749.1; Type=Frameshift; Evidence=; Sequence=BAB25873.1; Type=Frameshift; Evidence=; Sequence=CAC18551.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=EDL23160.1; Type=Erroneous gene model prediction; Evidence=; negative regulation of transcription from RNA polymerase II promoter molecular_function nucleic acid binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated spermatogenesis transcription factor binding sequence-specific DNA binding metal ion binding uc009fmj.1 uc009fmj.2 uc009fmj.3 
ENSMUST00000108458.10 Klc3 ENSMUST00000108458.10 kinesin light chain 3, transcript variant 3 (from RefSeq NM_001286039.2) ENSMUST00000108458.1 ENSMUST00000108458.2 ENSMUST00000108458.3 ENSMUST00000108458.4 ENSMUST00000108458.5 ENSMUST00000108458.6 ENSMUST00000108458.7 ENSMUST00000108458.8 ENSMUST00000108458.9 KLC3_MOUSE NM_001286039 Q3TZ56 Q91W40 uc009flt.1 uc009flt.2 uc009flt.3 uc009flt.4 Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (PubMed:22561200). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (PubMed:22561200). Oligomer composed of two heavy chains and two light chains (By similarity). Associates with microtubulin in an ATP-dependent manner (By similarity). Interacts with KIF5C. Interacts with ODF1 (By similarity). Interacts with LRGUK (PubMed:28003339). Interacts with VDAC2 (PubMed:22561200). Cytoplasm, cytoskeleton Mitochondrion Note=In elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria (By similarity). Also localizes to the manchette in elongating spermatids (PubMed:28003339). Expressed in postmeiotic male germ cells (at protein level) (PubMed:11319135). Expressed in the testes (at protein level) (PubMed:35547804). Expressed in spleen, intestine, brain and ovary (PubMed:11319135). The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity). Male transgenic mice (expressing a KLC3 deletion mutant) display significantly reduced reproductive efficiency siring small sized litters (PubMed:22561200). Show significantly reduced sperm count, defective mitochondrial sheath structure in a number of spermatids and produce spermatozoa that exhibit abnormal motility parameters (PubMed:22561200). Belongs to the kinesin light chain family. microtubule motor activity protein binding cytoplasm cytoskeleton kinesin complex microtubule microtubule binding axo-dendritic transport kinesin binding motile cilium ciliary rootlet intraciliary transport neuron projection uc009flt.1 uc009flt.2 uc009flt.3 uc009flt.4 
ENSMUST00000108464.3 Gm17146 ENSMUST00000108464.3 Gm17146 (from geneSymbol) ENSMUST00000108464.1 ENSMUST00000108464.2 uc290gqy.1 uc290gqy.2 uc290gqy.1 uc290gqy.2 
ENSMUST00000108473.10 Dmpk ENSMUST00000108473.10 dystrophia myotonica-protein kinase, transcript variant 3 (from RefSeq NM_001190491.2) DMPK_MOUSE Dm15 ENSMUST00000108473.1 ENSMUST00000108473.2 ENSMUST00000108473.3 ENSMUST00000108473.4 ENSMUST00000108473.5 ENSMUST00000108473.6 ENSMUST00000108473.7 ENSMUST00000108473.8 ENSMUST00000108473.9 Mdpk NM_001190491 P54265 uc009fkp.1 uc009fkp.2 uc009fkp.3 uc009fkp.4 uc009fkp.5 The protein encoded by this gene is a serine/threonine protein kinase that contains coiled-coil and C-terminal membrane association domains. In the embryonic mouse, it is found in cardiac and skeletal myocytes where it appears to play a role in myogenesis. In adults, the transcript is localized to several tissues including brain, heart, and skeletal and smooth muscle, and a function in cytoskeletal remodeling has been described. Transcripts with expanded CUG repeats in the 3' untranslated region mediate alternative splicing of several genes and sequester RNA binding proteins and RNA transcripts that contain CAG repeats, resulting in myotonic dystrophy, an autosomal dominant neuromuscular disorder. Alternative splicing results in multiple protein coding and non-coding transcript variants. [provided by RefSeq, Oct 2014]. Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Coiled-coil-mediated oligomerization enhances the catalytic activity. Proteolytic processing of the C-terminus may release the protein from membranes and constitute a mean to regulate the enzyme. May be regulated by HSPB2, RAC1, RAF1 and G-protein second messengers (By similarity). Homodimer; homodimerization stimulates the kinase activity. Interacts with HSPB2; may enhance DMPK kinase activity. Interacts with PLN; phosphorylates PLN. May interact with RAC1; may regulate DMPK kinase activity. Interacts with LMNA; may regulate nuclear envelope stability (By similarity). Sarcoplasmic reticulum membrane. Cell membrane. Note=Localizes to sarcoplasmic reticulum membranes of cardiomyocytes. [Isoform 1]: Endoplasmic reticulum membrane; Single-pass type IV membrane protein; Cytoplasmic side. Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. [Isoform 8]: Mitochondrion outer membrane; Single-pass type IV membrane protein. [Isoform 5]: Cytoplasm, cytosol. Event=Alternative splicing; Named isoforms=10; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=DMPK A; IsoId=P54265-1; Sequence=Displayed; Name=2; IsoId=P54265-2; Sequence=VSP_004819; Name=3; Synonyms=DMPK B; IsoId=P54265-3; Sequence=VSP_004820; Name=4; IsoId=P54265-4; Sequence=VSP_004820, VSP_004821, VSP_004822; Name=5; Synonyms=DMPK E; IsoId=P54265-5; Sequence=VSP_004823, VSP_004824; Name=6; Synonyms=DMPK F; IsoId=P54265-6; Sequence=VSP_004820, VSP_004823, VSP_004824; Name=7; IsoId=P54265-7; Sequence=VSP_004825, VSP_004826; Name=8; Synonyms=DMPK C; IsoId=P54265-8; Sequence=VSP_004827; Name=9; Synonyms=DMPK D; IsoId=P54265-9; Sequence=VSP_004820, VSP_004827; Name=10; IsoId=P54265-10; Sequence=VSP_004828, VSP_004829; Expressed in all tissues tested, with a predominance in brain, skeletal muscle, heart, and other tissues containing smooth muscle. In the heart, expression is restricted to the cardiomyocytes in the ventricle and atrium. Primarily detected in striated muscle structures of the 14.5 day embryo, including all major muscles in the skeletal structures, cardiac muscle, diaphragm, and the smooth muscle of the lung and gut. The coiled coil domain is required for homodimerization and regulates the enzymatic activity. Phosphorylated. Autophosphorylates. Phosphorylation by RAF1 may result in activation of DMPK (By similarity). Proteolytic processing of the C-terminus may remove the transmembrane domain and release the kinase from membranes stimulating its activity. Mice are fertile and no negative selection against the absence of the protein is apparent. Newborn do not display hypotonia, respiratory distress or gross anatomical abnormalities. However, a progressive muscle weakness a hall mark of myopathies is observed. Muscles from mature mice show variation in fiber size, increase fiber degeneration and fibrosis. They also display age-related progression in atrioventricular conduction defects that are reminiscent of congenital myotonic dystrophy. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. nucleotide binding regulation of sodium ion transport protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nuclear outer membrane cytoplasm mitochondrion mitochondrial outer membrane endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane protein phosphorylation cellular calcium ion homeostasis nuclear envelope organization regulation of heart contraction muscle cell apoptotic process regulation of myotube differentiation regulation of skeletal muscle contraction by calcium ion signaling regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction membrane integral component of membrane kinase activity phosphorylation sarcoplasmic reticulum transferase activity myosin phosphatase regulator activity peptidyl-serine phosphorylation integral component of mitochondrial outer membrane nuclear membrane sarcoplasmic reticulum membrane intracellular signal transduction regulation of phosphoprotein phosphatase activity metal ion binding regulation of synapse structural plasticity uc009fkp.1 uc009fkp.2 uc009fkp.3 uc009fkp.4 uc009fkp.5 
ENSMUST00000108481.8 Psg22 ENSMUST00000108481.8 Psg22 (from geneSymbol) BC080694 E9Q6J7 E9Q6J7_MOUSE ENSMUST00000108481.1 ENSMUST00000108481.2 ENSMUST00000108481.3 ENSMUST00000108481.4 ENSMUST00000108481.5 ENSMUST00000108481.6 ENSMUST00000108481.7 Psg22 uc291mfp.1 uc291mfp.2 uc291mfp.1 uc291mfp.2 
ENSMUST00000108482.8 Psg20 ENSMUST00000108482.8 pregnancy-specific beta-1-glycoprotein 20 (from RefSeq NM_054058.1) E9Q6J6 E9Q6J6_MOUSE ENSMUST00000108482.1 ENSMUST00000108482.2 ENSMUST00000108482.3 ENSMUST00000108482.4 ENSMUST00000108482.5 ENSMUST00000108482.6 ENSMUST00000108482.7 NM_054058 Psg20 uc291mfk.1 uc291mfk.2 molecular_function cellular_component biological_process uc291mfk.1 uc291mfk.2 
ENSMUST00000108485.9 Atp2a3 ENSMUST00000108485.9 ATPase, Ca++ transporting, ubiquitous, transcript variant 1 (from RefSeq NM_001163336.1) Atp2a3 ENSMUST00000108485.1 ENSMUST00000108485.2 ENSMUST00000108485.3 ENSMUST00000108485.4 ENSMUST00000108485.5 ENSMUST00000108485.6 ENSMUST00000108485.7 ENSMUST00000108485.8 NM_001163336 Q8R0X5 Q8R0X5_MOUSE uc007jzp.1 uc007jzp.2 uc007jzp.3 Catalyzes the hydrolysis of ATP coupled with the transport of calcium. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.10; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18106; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi- pass membrane protein rcoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. nucleotide binding calcium-transporting ATPase activity ATP binding endoplasmic reticulum ion transport calcium ion transport membrane integral component of membrane sarcoplasmic reticulum membrane calcium ion transmembrane transport uc007jzp.1 uc007jzp.2 uc007jzp.3 
ENSMUST00000108487.9 Ceacam12 ENSMUST00000108487.9 CEA cell adhesion molecule 12, transcript variant 2 (from RefSeq NM_001162523.1) Ceacam12 ENSMUST00000108487.1 ENSMUST00000108487.2 ENSMUST00000108487.3 ENSMUST00000108487.4 ENSMUST00000108487.5 ENSMUST00000108487.6 ENSMUST00000108487.7 ENSMUST00000108487.8 NM_001162523 Q3V2Q3 Q3V2Q3_MOUSE uc012fap.1 uc012fap.2 uc012fap.3 molecular_function cellular_component biological_process uc012fap.1 uc012fap.2 uc012fap.3 
ENSMUST00000108491.8 Ceacam3 ENSMUST00000108491.8 CEA cell adhesion molecule 3 (from RefSeq NM_054059.2) Ceacam3 E9Q6J4 E9Q6J4_MOUSE ENSMUST00000108491.1 ENSMUST00000108491.2 ENSMUST00000108491.3 ENSMUST00000108491.4 ENSMUST00000108491.5 ENSMUST00000108491.6 ENSMUST00000108491.7 NM_054059 uc012fal.1 uc012fal.2 uc012fal.3 molecular_function cellular_component biological_process uc012fal.1 uc012fal.2 uc012fal.3 
ENSMUST00000108492.9 Hif3a ENSMUST00000108492.9 hypoxia inducible factor 3, alpha subunit, transcript variant 1 (from RefSeq NM_001162950.1) A1IM61 E9QLB1 ENSMUST00000108492.1 ENSMUST00000108492.2 ENSMUST00000108492.3 ENSMUST00000108492.4 ENSMUST00000108492.5 ENSMUST00000108492.6 ENSMUST00000108492.7 ENSMUST00000108492.8 HIF3A_MOUSE Hif3a Mop7 NM_001162950 Nepas Q0VBL6 Q3UN40 Q8VHR1 Q9QX54 Q9Z2I5 uc009fis.1 uc009fis.2 uc009fis.3 uc009fis.4 Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:9840812, PubMed:11734856, PubMed:21546903). Plays a role in the development of the cardiorespiratory system (PubMed:18070924). [Isoform 1]: Acts as a positive regulator of hypoxia- inducible gene expression. Associates to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters in a ARNT-dependent manner, and hence also participates in the transcriptional activation of reporter genes driven by HRE (PubMed:9840812). [Isoform 2]: Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia- inducible target genes and hence inhibits HRE-driven transcriptional activation. Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. May act as a tumor suppressor (PubMed:11734856). May also be involved in apoptosis (PubMed:21546903). [Isoform 3]: Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia- inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:18070924). Also plays a role in the development of the lung and heart during embryonic and neonatal stages (PubMed:18070924). Isoform 1 interacts with ARNT (PubMed:9840812). Isoform 2 interacts with HIF1A (PubMed:11734856, PubMed:21546903). Isoform 2 interacts EPAS1 (PubMed:21546903). Isoform 2 interacts (via C-terminus domain) with BAD; the interaction reduces the binding between BAD and BAX (PubMed:21546903). Isoform 2 (via C-terminus domain) interacts with BCL2L2 and MCL1 (PubMed:21546903). Interacts with VHL (By similarity). Nucleus Cytoplasm Note=In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes. Localized in the cytoplasm and nuclei under normoxia, but increased in the nucleus under hypoxic conditions. Colocalized with HIF1A in kidney tumors. [Isoform 2]: Nucleus Cytoplasm Nucleus speckle Mitochondrion Note=Colocalizes with BAD in the cytoplasm (PubMed:21546903). Colocalizes with EPAS1 and HIF1A in the nucleus and speckles (PubMed:21546903). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:24092767). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q0VBL6-1; Sequence=Displayed; Name=2; IsoId=Q0VBL6-2; Sequence=VSP_024528, VSP_024529, VSP_024530, VSP_024531; Name=3; IsoId=Q0VBL6-3; Sequence=VSP_024528; Isoform 3 is expressed in endothelial cells of vessels and capillaries in alveoli of the neonatal lung (at protein level) (PubMed:18070924). Expressed in lung, brain, heart and kidney (PubMed:9840812). Isoform 2 is expressed in heart and lung (PubMed:12119283). Isoform 2 is highly expressed in the epithelial cell layer of the cornea with lower expression in the layers of ganglion cells, inner nuclear cells, and rods and cones of the retina (PubMed:11734856). Isoform 2 is expressed in the cerebellum only in the Purkinje cell layer (PubMed:11734856). Isoform 3 is expressed in brain, heart, lung, liver and kidney at 15.5 dpc. Isoform 3 is expressed in heart, lung, liver and kidney at 18.5 dpc. Isoform 2 is up-regulated in corneal epithelium cells under hypoxia (at protein level) (PubMed:11734856). Isoform 2 is up-regulated by hypoxia in a HIF1A-dependent manner (PubMed:12119283, PubMed:17355974). Isoform 3 is up-regulated by hypoxia (PubMed:18070924). [Isoform 2]: Contains a nuclear localization signal between amino acid positions 75 and 98. Contains a nuclear export signal between amino acid positions 228 and 272. In normoxia, hydroxylated on Pro-487 in the oxygen-dependent degradation domain (ODD) by PHD. The hydroxylated proline promotes interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation (By similarity). Ubiquitinated; ubiquitination occurs in a VHL- and oxygen- dependent pathway and subsequently targeted for proteasomal degradation. Mice appeared outwardly normal and are viable and fertile. Show hypertrophy of the right atrium and ventricle, disarrangement of striated muscle fibers in the heart, and pulmonary hyperplasia (PubMed:18070924). [Isoform 2]: Mutagenesis of Lys-75, Arg-76, Arg-97 and Arg-98 increase strongly cytoplasmic localization. Mutagenesis of Pro- 228, Pro-229, Leu-271 and Leu-272 increase strongly nuclear localization. RNA polymerase II transcription factor activity, sequence-specific DNA binding angiogenesis response to hypoxia DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm cytoplasm mitochondrion cytosol plasma membrane regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter apoptotic process multicellular organism development nuclear speck positive regulation of transcription from RNA polymerase II promoter protein dimerization activity negative regulation of nucleic acid-templated transcription uc009fis.1 uc009fis.2 uc009fis.3 uc009fis.4 
ENSMUST00000108493.3 Dact3 ENSMUST00000108493.3 dishevelled-binding antagonist of beta-catenin 3 (from RefSeq NM_001081655.1) DACT3_MOUSE ENSMUST00000108493.1 ENSMUST00000108493.2 NM_001081655 Q0PHV7 uc009fij.1 uc009fij.2 uc009fij.3 May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins (By similarity). Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, DVL1, DVL2, DVL3, VANGL1, VANGL2 and CTNND1. Q0PHV7; Q8R4A3: Dact1; NbExp=2; IntAct=EBI-6392520, EBI-3870250; Q0PHV7; Q7TN08: Dact2; NbExp=2; IntAct=EBI-6392520, EBI-6392494; Q0PHV7; Q0PHV7: Dact3; NbExp=2; IntAct=EBI-6392520, EBI-6392520; Expressed in brain and uterus. Expression peaks at 10.5 dpc, then declines. Expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, and in the developing central nervous system. The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins. Belongs to the dapper family. protein kinase C binding protein binding cytoplasm beta-catenin binding negative regulation of epithelial to mesenchymal transition Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway negative regulation of cell growth identical protein binding protein kinase A binding delta-catenin binding negative regulation of canonical Wnt signaling pathway uc009fij.1 uc009fij.2 uc009fij.3 
ENSMUST00000108496.9 Slc1a5 ENSMUST00000108496.9 solute carrier family 1 (neutral amino acid transporter), member 5 (from RefSeq NM_009201.2) ENSMUST00000108496.1 ENSMUST00000108496.2 ENSMUST00000108496.3 ENSMUST00000108496.4 ENSMUST00000108496.5 ENSMUST00000108496.6 ENSMUST00000108496.7 ENSMUST00000108496.8 NM_009201 Q9ESU7 Q9ESU7_MOUSE Slc1a5 uc009fib.1 uc009fib.2 uc009fib.3 Reaction=D-serine(in) + L-alanine(out) + Na(+)(out) = D-serine(out) + L-alanine(in) + Na(+)(in); Xref=Rhea:RHEA:75311, ChEBI:CHEBI:29101, ChEBI:CHEBI:35247, ChEBI:CHEBI:57972; Evidence=; Reaction=D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in); Xref=Rhea:RHEA:75307, ChEBI:CHEBI:29101, ChEBI:CHEBI:35247, ChEBI:CHEBI:58359; Evidence=; Reaction=H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) = H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in); Xref=Rhea:RHEA:70883, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; Evidence=; Reaction=L-alanine(out) + L-glutamine(in) + Na(+)(out) = L-alanine(in) + L-glutamine(out) + Na(+)(in); Xref=Rhea:RHEA:70867, ChEBI:CHEBI:29101, ChEBI:CHEBI:57972, ChEBI:CHEBI:58359; Evidence=; Reaction=L-asparagine(in) + L-glutamine(out) + Na(+)(out) = L- asparagine(out) + L-glutamine(in) + Na(+)(in); Xref=Rhea:RHEA:70859, ChEBI:CHEBI:29101, ChEBI:CHEBI:58048, ChEBI:CHEBI:58359; Evidence=; Reaction=L-asparagine(out) + L-glutamine(in) + Na(+)(out) = L- asparagine(in) + L-glutamine(out) + Na(+)(in); Xref=Rhea:RHEA:70891, ChEBI:CHEBI:29101, ChEBI:CHEBI:58048, ChEBI:CHEBI:58359; Evidence=; Reaction=L-glutamine(in) + L-methionine(out) + Na(+)(out) = L- glutamine(out) + L-methionine(in) + Na(+)(in); Xref=Rhea:RHEA:70875, ChEBI:CHEBI:29101, ChEBI:CHEBI:57844, ChEBI:CHEBI:58359; Evidence=; Reaction=L-glutamine(in) + L-serine(out) + Na(+)(out) = L- glutamine(out) + L-serine(in) + Na(+)(in); Xref=Rhea:RHEA:70887, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384, ChEBI:CHEBI:58359; Evidence=; Reaction=L-glutamine(in) + L-threonine(out) + Na(+)(out) = L- glutamine(out) + L-threonine(in) + Na(+)(in); Xref=Rhea:RHEA:70879, ChEBI:CHEBI:29101, ChEBI:CHEBI:57926, ChEBI:CHEBI:58359; Evidence=; Reaction=L-glutamine(in) + L-valine(out) + Na(+)(out) = L- glutamine(out) + L-valine(in) + Na(+)(in); Xref=Rhea:RHEA:70871, ChEBI:CHEBI:29101, ChEBI:CHEBI:57762, ChEBI:CHEBI:58359; Evidence=; Reaction=L-glutamine(out) + L-serine(in) + Na(+)(out) = L-glutamine(in) + L-serine(out) + Na(+)(in); Xref=Rhea:RHEA:70855, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384, ChEBI:CHEBI:58359; Evidence=; Reaction=L-glutamine(out) + L-threonine(in) + Na(+)(out) = L- glutamine(in) + L-threonine(out) + Na(+)(in); Xref=Rhea:RHEA:70863, ChEBI:CHEBI:29101, ChEBI:CHEBI:57926, ChEBI:CHEBI:58359; Evidence=; Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324, ChEBI:CHEBI:16382; Evidence=; Reaction=nitrate(in) = nitrate(out); Xref=Rhea:RHEA:34923, ChEBI:CHEBI:17632; Evidence=; Reaction=thiocyanate(in) = thiocyanate(out); Xref=Rhea:RHEA:75347, ChEBI:CHEBI:18022; Evidence=; Cell membrane ; Multi-pass membrane protein Melanosome Membrane ; Multi- pass membrane protein Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. plasma membrane glutamine transport glutamine secretion L-glutamine transmembrane transporter activity L-serine transmembrane transporter activity symporter activity L-serine transport membrane integral component of membrane protein homotrimerization L-glutamine import into cell uc009fib.1 uc009fib.2 uc009fib.3 
ENSMUST00000108498.3 Ceacam15 ENSMUST00000108498.3 CEA cell adhesion molecule 15 (from RefSeq NM_175315.1) A0A0B4J1L0 A0JLX4 CEA15_MOUSE Ceacam15 ENSMUST00000108498.1 ENSMUST00000108498.2 NM_175315 uc009fhy.1 uc009fhy.2 uc009fhy.3 Detected in placenta. Belongs to the immunoglobulin superfamily. CEA family. Sequence=AAI25405.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI25407.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component biological_process uc009fhy.1 uc009fhy.2 uc009fhy.3 
ENSMUST00000108504.2 Fbxo39 ENSMUST00000108504.2 F-box protein 39 (from RefSeq NM_001099688.2) ENSMUST00000108504.1 FBX39_MOUSE NM_001099688 Q5NBU5 uc007jys.1 uc007jys.2 uc007jys.3 uc007jys.4 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Directly interacts with SKP1 and CUL1. molecular_function SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process uc007jys.1 uc007jys.2 uc007jys.3 uc007jys.4 
ENSMUST00000108506.10 4933427D14Rik ENSMUST00000108506.10 RIKEN cDNA 4933427D14 gene, transcript variant 1 (from RefSeq NM_028963.3) 4933427D14Rik A0A0R4J1C3 A0A0R4J1C3_MOUSE ENSMUST00000108506.1 ENSMUST00000108506.2 ENSMUST00000108506.3 ENSMUST00000108506.4 ENSMUST00000108506.5 ENSMUST00000108506.6 ENSMUST00000108506.7 ENSMUST00000108506.8 ENSMUST00000108506.9 NM_028963 uc007jyd.1 uc007jyd.2 uc007jyd.3 uc007jyd.4 centriole replication uc007jyd.1 uc007jyd.2 uc007jyd.3 uc007jyd.4 
ENSMUST00000108513.5 Obox6 ENSMUST00000108513.5 oocyte specific homeobox 6 (from RefSeq NM_145710.2) A0PK85 ENSMUST00000108513.1 ENSMUST00000108513.2 ENSMUST00000108513.3 ENSMUST00000108513.4 G3X9U1 NM_145710 OBOX6_MOUSE Obox6 Q8VHG3 uc009fgk.1 uc009fgk.2 uc009fgk.3 Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization. Nucleus Specifically expressed in early embryos. Expressed zygotically with expression starting during major zygotic genome activation (ZGA) and peaking in four-cell stage embryos. No visible phenotype; mice are viable and fertile. Belongs to the paired homeobox family. Obox subfamily. Sequence=AAL68805.1; Type=Erroneous gene model prediction; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding uc009fgk.1 uc009fgk.2 uc009fgk.3 
ENSMUST00000108515.9 Nlrp1b ENSMUST00000108515.9 NLR family, pyrin domain containing 1B, transcript variant 3 (from RefSeq NM_001162414.2) A1Z198 ENSMUST00000108515.1 ENSMUST00000108515.2 ENSMUST00000108515.3 ENSMUST00000108515.4 ENSMUST00000108515.5 ENSMUST00000108515.6 ENSMUST00000108515.7 ENSMUST00000108515.8 F6R9S5 NL1B2_MOUSE NM_001162414 Nalp1b Nlrp1b Q2LK61 Q2LKV8 uc007jxs.1 uc007jxs.2 Acts as the sensor component of the Nlrp1b inflammasome, which mediates inflammasome activation in response to various pathogen- associated signals, leading to subsequent pyroptosis (By similarity). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (By similarity). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals: in response to pathogen-associated signals, the N-terminal part of Nlrp1b is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1b, C-terminus), which polymerizes to initiate the formation of the inflammasome complex: the inflammasome directly recruits pro-caspase-1 (proCASP1) independently of PYCARD/ASC and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (By similarity). In the absence of GSDMD expression, the Nlrp1b inflammasome is able to recruit and activate CASP8, leading to activation of gasdermin-E (GSDME) (By similarity). Activation of Nlrp1b inflammasome is also required for HMGB1 secretion; the active cytokines and HMGB1 stimulate inflammatory responses (By similarity). Contrary to Nlrp1b allele 1, allele 2 is not activated by Bacillus anthracis lethal toxin (PubMed:16429160, PubMed:21170303, PubMed:24492532). [NACHT, LRR and PYD domains-containing protein 1b allele 2]: Constitutes the precursor of the Nlrp1b inflammasome, which mediates autoproteolytic processing within the FIIND domain to generate the N- terminal and C-terminal parts, which are associated non-covalently in absence of pathogens and other damage-associated signals. [NACHT, LRR and PYD domains-containing protein 1b, N- terminus]: Regulatory part that prevents formation of the Nlrp1b inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of Nlrp1b (NACHT, LRR and PYD domains-containing protein 1b, C-terminus), preventing activation of the Nlrp1b inflammasome. In response to pathogen-associated signals, this part is ubiquitinated by the N-end rule pathway and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the Nlrp1b inflammasome. [NACHT, LRR and PYD domains-containing protein 1b, C- terminus]: Constitutes the active part of the Nlrp1b inflammasome. In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of Nlrp1b (NACHT, LRR and PYD domains- containing protein 1b, N-terminus), preventing activation of the Nlrp1b inflammasome. In response to pathogen-associated signals, the N- terminal part of Nlrp1b is degraded by the proteasome, releasing this form, which polymerizes to form the Nlrp1b inflammasome complex: the Nlrp1b inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis. Activated by pathogens and other damage-associated signals: activation promotes ubiquitination and degradation of the N- terminal part, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1b, C-terminus), which polymerizes and forms the Nlrp1b inflammasome (By similarity). Nlrp1b inflammasome is inhibited by DPP8 and DPP9, which sequester the C- terminal fragment of Nlrp1b (NACHT, LRR and PYD domains-containing protein 1b, C-terminus) in a ternary complex, thereby preventing Nlrp1b oligomerization and activation (By similarity). Nlrp1b inflammasome is activated by Val-boroPro (Talabostat, PT-100), an inhibitor of dipeptidyl peptidases DPP8 and DPP9 (PubMed:31383852). Val-boroPro relieves inhibition of DPP8 and/or DPP9 by promoting disruption of the ternary complex, releasing its C-terminal part from autoinhibition (By similarity). May be activated by Toxoplasma gondii, although at a lower extent than allele 1 (PubMed:24218483). Not activated by cleavage by B.anthracis lethal toxin (LT) endopeptidase (PubMed:16429160, PubMed:21170303, PubMed:24492532, PubMed:31383852). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Interacts with DPP9; leading to inhibit activation of the inflammasome (By similarity). DPP9 acts via formation of a ternary complex, composed of a DPP9 homodimer, one full-length Nlrp1b protein, and one cleaved C-terminus of Nlrp1b (NACHT, LRR and PYD domains- containing protein 1b, C-terminus) (By similarity). Interacts with DPP8; leading to inhibit activation of the inflammasome, probably via formation of a ternary complex with DPP8 (By similarity). Interacts (via LRR repeats) with BCL2 and BCL2L1 (via the loop between motifs BH4 and BH3). Interacts with NOD2; this interaction may increase IL1B release (By similarity). Interacts with EIF2AK2/PKR; this interaction requires EIF2AK2 activity, is accompanied by EIF2AK2 autophosphorylation and promotes inflammasome assembly in response to B.anthracis lethal toxin (By similarity). Interacts with MEFV; this interaction targets Nlrp1b to degradation by autophagy, hence preventing excessive IL1B- and IL18-mediated inflammation (By similarity). [NACHT, LRR and PYD domains-containing protein 1b, N- terminus]: Interacts with the C-terminal part of Nlrp1b (NACHT, LRR and PYD domains-containing protein 1b, C-terminus) in absence of pathogens and other damage-associated signals. [NACHT, LRR and PYD domains-containing protein 1b, C- terminus]: Interacts with the N-terminal part of Nlrp1b (NACHT, LRR and PYD domains-containing protein 1b, N-terminus) in absence of pathogens and other damage-associated signals. Homomultimer; forms the Nlrp1b inflammasome polymeric complex, a filament composed of homopolymers of this form in response to pathogens and other damage-associated signals. The Nlrp1b inflammasome polymeric complex directly recruits pro- caspase-1 (proCASP1) independently of PYCARD/ASC. Interacts (via CARD domain) with CASP1 (via CARD domain); leading to CASP1 activation. Cytoplasm, cytosol [NACHT, LRR and PYD domains-containing protein 1b, C-terminus]: Inflammasome Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A1Z198-1; Sequence=Displayed; Name=2; IsoId=A1Z198-2; Sequence=VSP_058005; Name=3; IsoId=A1Z198-3; Sequence=VSP_058005, VSP_058006, VSP_058007; Widely expressed, including in macrophages and, at lower levels, in the peripheral nervous system, including in the sciatic nerve, Schwann cells, sensory neurons and motor neurons. Up-regulated transiently following acute injury of the sciatic nerve with a peak after 44 hours. The CARD domain is involved in the interaction with CASP1 and CASP4/CASP11. The leucine-rich repeat (LRR) domain may be involved in autoinhibition in the absence of activating signal, possibly through intramolecular interaction with the NACHT domain. The FIIND (domain with function to find) region is involved in homomerization, but not in CASP1-binding. In allele 1, autocatalytic cleavage in this region occurs constitutively, prior to activation signals, and is required for inflammasome activity (IL1B release), possibly by facilitating CASP1 binding. Both N- and C-terminal fragments remain associated (By similarity). It is not known whether this modification occurs in allele 2 (Probable). [NACHT, LRR and PYD domains-containing protein 1b, C-terminus]: The C-terminal part of Nlrp1b oligomerizes to form the core of the Nlrp1b inflammasome filament: in the filament, the CARD domains form a central helical filaments that are promoted by oligomerized, but flexibly linked, UPA regions surrounding the filaments. The UPA region reduces the threshold needed for filament formation and signaling. [NACHT, LRR and PYD domains-containing protein 1b allele 2]: Autocatalytically cleaved. Autocatalytic cleavage in FIIND region occurs constitutively, prior to activation signals, and is required for inflammasome activity (IL1B release), possibly by facilitating CASP1 binding. Both N- and C-terminal parts remain associated non-covalently. [NACHT, LRR and PYD domains-containing protein 1b, N-terminus]: Ubiquitinated by the N-end rule pathway in response to pathogens and other damage-associated signals, leading to its degradation by the proteasome and subsequent release of the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1b, C-terminus), which polymerizes and forms the Nlrp1b inflammasome. Nlrp1b gene is extremely polymorphic. 5 alleles have been described in 18 inbred strains: 1 (AC Q2LKW6), 2 (this entry), 3 (AC Q2LKV5), 4 (AC Q2LKV2) and 5 (AC Q0GKD5). These alleles define susceptibility to B.anthracis lethal toxin (LT). Alleles 2 (carried by A/J, C57BL/6J and I/LnJ), 3 (AKR/J, NOD/LtJ and SJL/J) or 4 (DBA/2J, P/J and SM/J) are not activated by LT. Alleles 1 (carried by 129S1/SvImJ, BALB/cJ, C3H/HeJ, CBA/J, FVB/NJ, NON/ShiLtJ, NZO (NZO/HlLtJ) and SWR/J strains) and 5 (CAST/EiJ) confer macrophage susceptibility to LT. In susceptible strains, infection by Bacillus anthracis leads to IL1B release, neutrophil recruitment and macrophage pyroptosis. This early inflammatory response confers increased resistance to infection (PubMed:16429160). The sequence shown in this entry is that of allele 2 (PubMed:16429160). Three tandem Nrlp1 paralogs, Nrlp1a, Nrlp1b and Nrlp1c, have been identified. Nlrp1c is predicted to be a pseudogene. [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the NLRP family. nucleotide binding immune system process ATP binding nucleus nucleoplasm cytoplasm cytosol activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response enzyme binding protein domain specific binding protein catabolic process interleukin-1 alpha production interleukin-1 beta production regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process innate immune response positive regulation of interleukin-1 beta secretion neuron apoptotic process inflammasome complex pyroptosis NLRP1 inflammasome complex NLRP1 inflammasome complex assembly uc007jxs.1 uc007jxs.2 
ENSMUST00000108522.5 Sult2a1 ENSMUST00000108522.5 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (from RefSeq NM_001111296.2) ENSMUST00000108522.1 ENSMUST00000108522.2 ENSMUST00000108522.3 ENSMUST00000108522.4 NM_001111296 P52843 ST2A1_MOUSE Sta1 uc009ffz.1 uc009ffz.2 uc009ffz.3 uc009ffz.4 This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC145167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:12639899). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism (By similarity). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity). Reaction=3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'- bisphosphate + an alkyl sulfate + H(+); Xref=Rhea:RHEA:22552, ChEBI:CHEBI:15378, ChEBI:CHEBI:30879, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:83414; EC=2.8.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22553; Evidence=; Reaction=3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate; Xref=Rhea:RHEA:14013, ChEBI:CHEBI:15378, ChEBI:CHEBI:17179, ChEBI:CHEBI:58301, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343; EC=2.8.2.14; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14014; Evidence=; Reaction=3'-phosphoadenylyl sulfate + pregnenolone = adenosine 3',5'- bisphosphate + H(+) + pregnenolone sulfate; Xref=Rhea:RHEA:52356, ChEBI:CHEBI:15378, ChEBI:CHEBI:16581, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:133000; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52357; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+); Xref=Rhea:RHEA:51216, ChEBI:CHEBI:15378, ChEBI:CHEBI:28689, ChEBI:CHEBI:57905, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51217; Evidence=; Reaction=3'-phosphoadenylyl sulfate + lithocholate = adenosine 3',5'- bisphosphate + H(+) + lithocholate sulfate; Xref=Rhea:RHEA:51064, ChEBI:CHEBI:15378, ChEBI:CHEBI:29744, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:133940; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51065; Evidence=; Reaction=(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)- hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:52344, ChEBI:CHEBI:15378, ChEBI:CHEBI:34310, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136566; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52345; Evidence=; Reaction=(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)- hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:52348, ChEBI:CHEBI:15378, ChEBI:CHEBI:34310, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136567; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52349; Evidence=; Reaction=(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'- bisphosphate + H(+); Xref=Rhea:RHEA:52352, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136566, ChEBI:CHEBI:136568; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52353; Evidence=; Reaction=3'-phosphoadenylyl sulfate + androsterone = adenosine 3',5'- bisphosphate + androsterone 3alpha-sulfate + H(+); Xref=Rhea:RHEA:60644, ChEBI:CHEBI:15378, ChEBI:CHEBI:16032, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:133003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60645; Evidence=; Homodimer. Cytoplasm Highly expressed in liver. Not expressed until 19 dpc. Belongs to the sulfotransferase 1 family. alcohol sulfotransferase activity cytoplasm cytosol lipid metabolic process drug binding sulfotransferase activity steroid metabolic process transferase activity bile-salt sulfotransferase activity steroid sulfotransferase activity 3'-phosphoadenosine 5'-phosphosulfate binding sulfation uc009ffz.1 uc009ffz.2 uc009ffz.3 uc009ffz.4 
ENSMUST00000108525.4 Sult2a5 ENSMUST00000108525.4 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 5 (from RefSeq NM_001184980.1) ENSMUST00000108525.1 ENSMUST00000108525.2 ENSMUST00000108525.3 K7N6K9 K7N6K9_MOUSE NM_001184980 Sult2a5 uc012ezp.1 uc012ezp.2 This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Belongs to the sulfotransferase 1 family. alcohol sulfotransferase activity cytoplasm cytosol drug binding sulfotransferase activity biological_process transferase activity bile-salt sulfotransferase activity steroid sulfotransferase activity 3'-phosphoadenosine 5'-phosphosulfate binding uc012ezp.1 uc012ezp.2 
ENSMUST00000108526.6 Bsph2 ENSMUST00000108526.6 binder of sperm protein homolog 2 (from RefSeq NM_001080942.2) BSPH2_MOUSE Bsph2 ENSMUST00000108526.1 ENSMUST00000108526.2 ENSMUST00000108526.3 ENSMUST00000108526.4 ENSMUST00000108526.5 NM_001080942 Q0Q236 uc009ffx.1 uc009ffx.2 uc009ffx.3 Binds sperm in vitro but has no effect on sperm capacitation. Also binds gelatin and heparin, but not chondroitin sulfate B or phospholipid liposomes. Secreted Epididymis. Belongs to the seminal plasma protein family. extracellular region heparin binding cell surface sperm capacitation uc009ffx.1 uc009ffx.2 uc009ffx.3 
ENSMUST00000108527.8 Dhx33 ENSMUST00000108527.8 DEAH-box helicase 33 (from RefSeq NM_178367.4) DHX33_MOUSE Dhx33 ENSMUST00000108527.1 ENSMUST00000108527.2 ENSMUST00000108527.3 ENSMUST00000108527.4 ENSMUST00000108527.5 ENSMUST00000108527.6 ENSMUST00000108527.7 NM_178367 Q80VY9 Q8BS50 uc007jxg.1 uc007jxg.2 uc007jxg.3 Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (By similarity). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (By similarity). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (PubMed:24037184). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Interacts with UBTF (PubMed:21930779). Interacts with DDX3X, EIF3G and EIF3H; the interaction is independent of RNA (PubMed:26100019). Interacts (via HA2 region and Helicase C-terminal domain) with the components of the large ribosomal subunit RPL3, RPL7, RPL26 and RPL27 (PubMed:26100019). Binds to mRNA (PubMed:26100019). Interacts (via the helicase C-terminal domain) with MAVS (PubMed:24037184). Binds to double-stranded RNA (via the helicase C- terminal domain) (PubMed:24037184). Nucleus, nucleolus Nucleus, nucleoplasm Cytoplasm Nucleus Inflammasome Note=Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions. Upon dsRNA-binding, localizes in the inflammasome. Ubiquitinated, leading to its degradation by the proteasome (PubMed:29273634). Deubiquitinated by USP36 (PubMed:29273634). Belongs to the DEAD box helicase family. DEAH subfamily. nucleotide binding rDNA binding nucleic acid binding RNA binding RNA helicase activity double-stranded RNA binding mRNA binding helicase activity protein binding ATP binding nucleus nucleoplasm nucleolus cytoplasm translational initiation hydrolase activity positive regulation of type I interferon production activating transcription factor binding ribosomal large subunit binding positive regulation of MAPK cascade positive regulation of transcription from RNA polymerase I promoter positive regulation of NF-kappaB transcription factor activity inflammasome complex NLRP3 inflammasome complex positive regulation of NLRP3 inflammasome complex assembly uc007jxg.1 uc007jxg.2 uc007jxg.3 
ENSMUST00000108530.2 Nup88 ENSMUST00000108530.2 nucleoporin 88, transcript variant 1 (from RefSeq NM_172394.3) ENSMUST00000108530.1 NM_172394 NUP88_MOUSE Q80Z13 Q8CEC0 Q8K090 uc007jwx.1 uc007jwx.2 uc007jwx.3 uc007jwx.4 Component of nuclear pore complex. Interacts with NUP214/CAN. Interacts with NUP62 and NUP98. Nucleus, nuclear pore complex Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CEC0-1; Sequence=Displayed; Name=2; IsoId=Q8CEC0-2; Sequence=VSP_011196; Name=3; IsoId=Q8CEC0-3; Sequence=VSP_011195, VSP_011196; ribosomal large subunit export from nucleus ribosomal small subunit export from nucleus mitotic cell cycle nucleus nuclear pore nucleoplasm mRNA export from nucleus protein import into nucleus protein export from nucleus nucleocytoplasmic transport protein transport structural constituent of nuclear pore mRNA transport uc007jwx.1 uc007jwx.2 uc007jwx.3 uc007jwx.4 
ENSMUST00000108532.11 Zswim9 ENSMUST00000108532.11 zinc finger SWIM-type containing 9 (from RefSeq NM_177312.4) 6330408A02Rik A0A0R4J1C4 A0A0R4J1C4_MOUSE ENSMUST00000108532.1 ENSMUST00000108532.10 ENSMUST00000108532.2 ENSMUST00000108532.3 ENSMUST00000108532.4 ENSMUST00000108532.5 ENSMUST00000108532.6 ENSMUST00000108532.7 ENSMUST00000108532.8 ENSMUST00000108532.9 NM_177312 Zswim9 uc009ffl.1 uc009ffl.2 uc009ffl.3 zinc ion binding uc009ffl.1 uc009ffl.2 uc009ffl.3 
ENSMUST00000108534.9 Scimp ENSMUST00000108534.9 SLP adaptor and CSK interacting membrane protein (from RefSeq NM_001045526.2) B2RVG2 ENSMUST00000108534.1 ENSMUST00000108534.2 ENSMUST00000108534.3 ENSMUST00000108534.4 ENSMUST00000108534.5 ENSMUST00000108534.6 ENSMUST00000108534.7 ENSMUST00000108534.8 NM_001045526 Q3UU41 Q5SX69 SCIMP_MOUSE uc007jwp.1 uc007jwp.2 uc007jwp.3 Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:27288407, PubMed:28290451, PubMed:28098138). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (By similarity). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (PubMed:27288407). It also acts as an agonist- inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (PubMed:28098138). Interacts with CD37, CD53 and CD81 (By similarity). Interacts (via proline-rich region) with LYN (via SH3 domain) (PubMed:28098138). Interacts with CSK (via SH2 domain); this interaction is dependent on phosphorylation of Tyr-96 (PubMed:28290451). Interacts with BLNK (via SH2 domain); this interaction is dependent on phosphorylation of Tyr- 120 (PubMed:21930792, PubMed:28290451). Interacts with GRB2 (via SH2 domain); this interaction may be dependent on phosphorylation of Tyr-58 (PubMed:21930792, PubMed:28098138). Interacts with TLR4; this interaction occurs upon lipopolysaccharide activation of TLR4 and is enhanced by phosphorylation of Tyr-96 by LYN (PubMed:28098138). This interaction facilitates the phosphorylation of TLR4 by LYN which elicits a selective cytokine response in macrophages (PubMed:28098138). Cell membrane ; Single-pass membrane protein Cell membrane ; Lipid-anchor Cytoplasmic vesicle, phagosome Cell projection, ruffle Cell projection, filopodium Note=Together with MHC-II, associates with lipid-enriched microdomains called tetraspanin-enriched microdomains (TEMs) (By similarity). Rapidly translocates into immunological synapse (IS) at cell-cell contacts between antigen- presenting cells (APCs) and T-cells (By similarity). Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod (By similarity). Present at regions of cell-cell contacts but also at the leading edge of migrating cells (By similarity). Localizes to phagosomes in dendritic cells after exposure to particulate beta-glucan (PubMed:27288407). Expressed in peripheral blood leukocytes (PBLs) (at protein level) (PubMed:21930792). Expressed in dendritic cells, splenocytes and B cells (at protein level) (PubMed:27288407). Strongly expressed in the spleen and lymph nodes and weakly in other tissues of the immune system, including bone marrow, peripheral blood leukocytes (PBLs) and thymus (PubMed:21930792). Not detected in the majority of nonimmune tissues, with the exception of lung (PubMed:21930792). Expressed in antigen-presenting cells (PubMed:21930792). Expressed in macrophages (PubMed:28098138). Induced in bone marrow-derived macrophages by CSF2 and particulate beta-glucan. Phosphorylated by the Src-family protein tyrosine kinases LYN and SRC (PubMed:27288407). Phosphorylation occurs on tyrosine residues upon MHC-II stimulation (PubMed:21930792, PubMed:27288407). Phosphorylation also occurs on tyrosine residues after activation of CLEC7A/DECTIN1 by particulate beta-glucan (PubMed:27288407). Lipopolysaccharide (LPS) induces phosphorylation of Tyr-58, Tyr-96 and Tyr-120 differentially to allow temporal recruitment of effector proteins GRB2, CSK and BLNK (PubMed:28290451). Phosphorylation of Tyr-58 is immediately induced by LPS stimulation and allows GRB2 to bind (PubMed:28290451). Tyr-96 is phosphorylated 5 minutes after LPS stimulation, which then allows CSK to bind, followed by phosphorylation of Tyr-120 10 minutes after LPS induction, which allows BLNK to bind (PubMed:28290451). Phosphorylation at Tyr-96 by LYN occurs after activation of TLR4 by LPS; phosphorylation enhances binding to TLR4 (PubMed:28098138, PubMed:28290451). Palmitoylated. Mice exhibit no difference in leukocyte development and subset representation in lymphoid organs (PubMed:27288407). No effect on B cell mediated activation of antigen- specific T cells and MHCII glycoprotein downstream signaling in B cells (PubMed:27288407). In dendritic cells, mutants show decreased cytokine production beyond 24 hours after stimulation of CLEC7A signaling (PubMed:27288407). Sequence=CAI25187.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAM28154.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; immunological synapse cytokine production involved in immune response positive regulation of dendritic cell cytokine production protein binding mitochondrion microtubule binding membrane integral component of membrane leading edge membrane uropod membrane positive regulation of lipopolysaccharide-mediated signaling pathway positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of stress-activated MAPK cascade toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor 7 signaling pathway toll-like receptor TLR1:TLR2 signaling pathway positive regulation of apoptotic process receptor complex phagocytic vesicle binding, bridging positive regulation of ERK1 and ERK2 cascade cellular response to molecule of fungal origin tetraspanin-enriched microdomain ruffle filopodium uc007jwp.1 uc007jwp.2 uc007jwp.3 
ENSMUST00000108544.8 Camta2 ENSMUST00000108544.8 calmodulin binding transcription activator 2, transcript variant 2 (from RefSeq NM_001190376.1) B0QZH5 CMTA2_MOUSE ENSMUST00000108544.1 ENSMUST00000108544.2 ENSMUST00000108544.3 ENSMUST00000108544.4 ENSMUST00000108544.5 ENSMUST00000108544.6 ENSMUST00000108544.7 Kiaa0909 NM_001190376 Q3TFK0 Q5SX54 Q5SX68 Q6PHS5 Q80TP1 Q80Y50 Q8R0D9 Q8R2N5 uc007jwd.1 uc007jwd.2 uc007jwd.3 Transcription activator. May act as tumor suppressor (By similarity). May interact with calmodulin. Nucleus Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q80Y50-1; Sequence=Displayed; Name=2; IsoId=Q80Y50-2; Sequence=VSP_018496; Name=3; IsoId=Q80Y50-3; Sequence=VSP_018494, VSP_018496, VSP_018499; Name=4; IsoId=Q80Y50-4; Sequence=VSP_018495, VSP_018499; Name=5; IsoId=Q80Y50-5; Sequence=VSP_018497, VSP_018498; Belongs to the CAMTA family. DNA binding chromatin binding nucleus regulation of transcription from RNA polymerase II promoter transcription factor binding cardiac muscle hypertrophy in response to stress histone deacetylase binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc007jwd.1 uc007jwd.2 uc007jwd.3 
ENSMUST00000108550.4 Vmn2r49 ENSMUST00000108550.4 vomeronasal 2, receptor 49 (from RefSeq NM_001105156.1) D3Z6L3 D3Z6L3_MOUSE ENSMUST00000108550.1 ENSMUST00000108550.2 ENSMUST00000108550.3 NM_001105156 Vmn2r49 uc012eyn.1 uc012eyn.2 uc012eyn.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012eyn.1 uc012eyn.2 uc012eyn.3 
ENSMUST00000108554.6 Vmn2r38 ENSMUST00000108554.6 vomeronasal 2, receptor 38 (from RefSeq NM_001105070.1) ENSMUST00000108554.1 ENSMUST00000108554.2 ENSMUST00000108554.3 ENSMUST00000108554.4 ENSMUST00000108554.5 G3UYA8 G3UYA8_MOUSE NM_001105070 Vmn2r38 Vmn2r39 uc012eyc.1 uc012eyc.2 uc012eyc.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012eyc.1 uc012eyc.2 uc012eyc.3 
ENSMUST00000108567.9 Zfp444 ENSMUST00000108567.9 Nucleus (from UniProt Q3TDV8) AK089886 ENSMUST00000108567.1 ENSMUST00000108567.2 ENSMUST00000108567.3 ENSMUST00000108567.4 ENSMUST00000108567.5 ENSMUST00000108567.6 ENSMUST00000108567.7 ENSMUST00000108567.8 Q3TDV8 Q3TDV8_MOUSE Zfp444 uc009fas.1 uc009fas.2 uc009fas.3 uc009fas.4 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009fas.1 uc009fas.2 uc009fas.3 uc009fas.4 
ENSMUST00000108572.2 Zfp579 ENSMUST00000108572.2 zinc finger protein 579 (from RefSeq NM_026741.2) ENSMUST00000108572.1 NM_026741 Q80VM4 ZN579_MOUSE Znf579 uc009ezc.1 uc009ezc.2 uc009ezc.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus biological_process metal ion binding uc009ezc.1 uc009ezc.2 uc009ezc.3 
ENSMUST00000108576.10 0610010K14Rik ENSMUST00000108576.10 RIKEN cDNA 0610010K14 gene, transcript variant 1 (from RefSeq NM_001177601.1) 0610010K14Rik D3Z687 D3Z687_MOUSE ENSMUST00000108576.1 ENSMUST00000108576.2 ENSMUST00000108576.3 ENSMUST00000108576.4 ENSMUST00000108576.5 ENSMUST00000108576.6 ENSMUST00000108576.7 ENSMUST00000108576.8 ENSMUST00000108576.9 NM_001177601 uc011xxr.1 uc011xxr.2 uc011xxr.3 DNA binding NURF complex MLL1 complex uc011xxr.1 uc011xxr.2 uc011xxr.3 
ENSMUST00000108593.8 Ctdnep1 ENSMUST00000108593.8 CTD nuclear envelope phosphatase 1 (from RefSeq NM_026017.2) CNEP1_MOUSE Dullard ENSMUST00000108593.1 ENSMUST00000108593.2 ENSMUST00000108593.3 ENSMUST00000108593.4 ENSMUST00000108593.5 ENSMUST00000108593.6 ENSMUST00000108593.7 NM_026017 Q3TP92 Q5NCW4 Q8VEL4 uc007jtf.1 uc007jtf.2 uc007jtf.3 uc007jtf.4 Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity). Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2. Endoplasmic reticulum membrane ; Single-pass membrane protein Nucleus membrane ; Single-pass membrane protein Muscle specific with lower expression in other metabolic tissues. Belongs to the dullard family. phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein binding nucleus nuclear envelope cytoplasm endoplasmic reticulum endoplasmic reticulum membrane lipid particle protein dephosphorylation nuclear envelope organization gamete generation mesoderm development positive regulation of triglyceride biosynthetic process membrane integral component of membrane hydrolase activity phosphatase activity nuclear membrane protein localization to nucleus Nem1-Spo7 phosphatase complex positive regulation of canonical Wnt signaling pathway uc007jtf.1 uc007jtf.2 uc007jtf.3 uc007jtf.4 
ENSMUST00000108594.8 Elp5 ENSMUST00000108594.8 elongator acetyltransferase complex subunit 5, transcript variant 1 (from RefSeq NM_018740.2) Derp6 ELP5_MOUSE ENSMUST00000108594.1 ENSMUST00000108594.2 ENSMUST00000108594.3 ENSMUST00000108594.4 ENSMUST00000108594.5 ENSMUST00000108594.6 ENSMUST00000108594.7 NM_018740 O08973 Q99L85 Q9CUX2 Rai12 uc007jte.1 uc007jte.2 uc007jte.3 uc007jte.4 uc007jte.5 uc007jte.6 Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in cell migration (PubMed:22854966). tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Component of the elongator complex which consists of ELP1, ELP2, ELP3, ELP4, ELP5 and ELP6; in the complex, is required for optimal binding of ELP3 to ELP4. Nucleus Cytoplasm Widely expressed with highest levels in testis (PubMed:9371513). Expressed throughout the cerebellum (PubMed:30097576). Tyrosine-phosphorylated. Belongs to the ELP5 family. The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification. tRNA wobble uridine modification nucleus cytoplasm cytosol positive regulation of cell migration Elongator holoenzyme complex uc007jte.1 uc007jte.2 uc007jte.3 uc007jte.4 uc007jte.5 uc007jte.6 
ENSMUST00000108597.8 Cldn7 ENSMUST00000108597.8 claudin 7, transcript variant 2 (from RefSeq NM_001193619.1) CLD7_MOUSE ENSMUST00000108597.1 ENSMUST00000108597.2 ENSMUST00000108597.3 ENSMUST00000108597.4 ENSMUST00000108597.5 ENSMUST00000108597.6 ENSMUST00000108597.7 NM_001193619 Q3TJX4 Q9Z261 uc011xxl.1 uc011xxl.2 uc011xxl.3 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed constitutively in the mammary epithelium throughout development, and might be involved in vesicle trafficking to the basolateral membrane. It is essential for NaCl homeostasis in distal nephrons. The knockout mice lacking this gene showed severe salt wasting, chronic dehydration, and growth retardation, and died within 12 days after birth. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (PubMed:10601346). The phosphorylated form interacts with EPCAM (By similarity). Cell membrane ; Multi-pass membrane protein Basolateral cell membrane Cell junction, tight junction Note=Colocalizes with EPCAM at the basolateral cell membrane and tight junction. Expressed predominantly in lung and kidney. Phosphorylated. Belongs to the claudin family. structural molecule activity protein binding plasma membrane bicellular tight junction negative regulation of cell adhesion positive regulation of cell proliferation membrane integral component of membrane basolateral plasma membrane apicolateral plasma membrane lateral plasma membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction negative regulation of protein homooligomerization identical protein binding negative regulation of apoptotic process response to ethanol cell adhesion molecule binding positive regulation of cell motility uc011xxl.1 uc011xxl.2 uc011xxl.3 
ENSMUST00000108601.3 Ybx2 ENSMUST00000108601.3 Y box protein 2, transcript variant 2 (from RefSeq NM_001347634.3) A0A0A0MQD2 A0A0A0MQD2_MOUSE ENSMUST00000108601.1 ENSMUST00000108601.2 NM_001347634 Ybx2 uc057klm.1 uc057klm.2 uc057klm.3 nucleic acid binding uc057klm.1 uc057klm.2 uc057klm.3 
ENSMUST00000108628.8 Tnk1 ENSMUST00000108628.8 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; (from UniProt Q5F2B4) BC055303 ENSMUST00000108628.1 ENSMUST00000108628.2 ENSMUST00000108628.3 ENSMUST00000108628.4 ENSMUST00000108628.5 ENSMUST00000108628.6 ENSMUST00000108628.7 Q5F2B4 Q5F2B4_MOUSE Tnk1 uc287zki.1 uc287zki.2 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; protein kinase activity protein tyrosine kinase activity ATP binding protein phosphorylation peptidyl-tyrosine phosphorylation uc287zki.1 uc287zki.2 
ENSMUST00000108630.8 Tsen34 ENSMUST00000108630.8 tRNA splicing endonuclease subunit 34, transcript variant 8 (from RefSeq NM_001420054.1) ENSMUST00000108630.1 ENSMUST00000108630.2 ENSMUST00000108630.3 ENSMUST00000108630.4 ENSMUST00000108630.5 ENSMUST00000108630.6 ENSMUST00000108630.7 Leng5 NM_001420054 Q58EU2 Q8BMZ5 Q99LV6 Q9CYW1 SEN34_MOUSE Sen34 uc009evv.1 uc009evv.2 uc009evv.3 uc009evv.4 Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'- end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity). Reaction=pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'- half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.; EC=4.6.1.16; tRNA splicing endonuclease is a heterotetramer composed of TSEN2, TSEN15, TSEN34/LENG5 and TSEN54. tRNA splicing endonuclease complex also contains proteins of the pre-mRNA 3'-end processing machinery such as CLP1, CPSF1, CPSF4 and CSTF2 (By similarity). Nucleus Nucleus, nucleolus Note=May be transiently localized in the nucleolus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BMZ5-1; Sequence=Displayed; Name=2; IsoId=Q8BMZ5-2; Sequence=VSP_010987; Belongs to the tRNA-intron endonuclease family. tRNA-intron endonuclease activity tRNA-intron endonuclease complex tRNA-type intron splice site recognition and cleavage nucleic acid binding nuclease activity protein binding nucleus nucleolus tRNA splicing, via endonucleolytic cleavage and ligation mRNA processing tRNA processing lyase activity nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc009evv.1 uc009evv.2 uc009evv.3 uc009evv.4 
ENSMUST00000108633.9 Plscr3 ENSMUST00000108633.9 phospholipid scramblase 3, transcript variant 1 (from RefSeq NM_023564.4) ENSMUST00000108633.1 ENSMUST00000108633.2 ENSMUST00000108633.3 ENSMUST00000108633.4 ENSMUST00000108633.5 ENSMUST00000108633.6 ENSMUST00000108633.7 ENSMUST00000108633.8 NM_023564 PLS3_MOUSE Q9JIZ9 uc007jrz.1 uc007jrz.2 uc007jrz.3 Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (By similarity). Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (By similarity). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (Probable). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (By similarity). Regulates cardiolipin de novo biosynthesis and its resynthesis (By similarity). Reaction=a cardiolipin(in) = a cardiolipin(out); Xref=Rhea:RHEA:38695, ChEBI:CHEBI:62237; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38696; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2- diacyl-sn-glycero-3-phosphoethanolamine(out); Xref=Rhea:RHEA:38895, ChEBI:CHEBI:64612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38896; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38572; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38573; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38664; Evidence=; Reaction=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) = 1,2- diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out); Xref=Rhea:RHEA:39743, ChEBI:CHEBI:64716; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39744; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Monomer (By similarity). Forms homooligomers upon binding to Ca(2+), Pb(2+) and Hg(2+) ions (By similarity). Interacts with PDCD6 in a calcium-dependent manner (By similarity). Interacts with PRKCD; interaction is enhanced by UV irradiation (PubMed:19428821). Mitochondrion membrane ; Single-pass type II membrane protein Mitochondrion inner membrane ; Single-pass type II membrane protein Nucleus Note=Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. The Proline-rich domain is required for phospholipid scramblase activity. Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. Belongs to the phospholipid scramblase family. mitochondrion plasma membrane apoptotic process membrane integral component of membrane phospholipid scrambling SH3 domain binding phospholipid scramblase activity mitochondrial membrane glucose homeostasis cholesterol homeostasis calcium-dependent protein binding cellular response to lipopolysaccharide uc007jrz.1 uc007jrz.2 uc007jrz.3 
ENSMUST00000108634.9 Nlgn2 ENSMUST00000108634.9 neuroligin 2, transcript variant 1 (from RefSeq NM_001364137.1) ENSMUST00000108634.1 ENSMUST00000108634.2 ENSMUST00000108634.3 ENSMUST00000108634.4 ENSMUST00000108634.5 ENSMUST00000108634.6 ENSMUST00000108634.7 ENSMUST00000108634.8 Kiaa1366 NLGN2_MOUSE NM_001364137 Q5F288 Q69ZK9 uc007jrx.1 uc007jrx.2 uc007jrx.3 Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (PubMed:29742426). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Interacts with neurexins NRXN1, NRXN2 and NRXN3 (By similarity). Interaction with neurexins is mediated by heparan sulfate glycan modification on neurexin (PubMed:30100184). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with PATJ (By similarity). Interacts with MDGA2 (By similarity). Interacts with GPHN (PubMed:19755106). Interacts with MDGA1 (PubMed:23358245). Found in a complex with MAGI2 and IGSF9B, where it interacts with MAGI2 (via WW 1, WW 2 and PDZ 2 domains) (PubMed:23751499). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Interacts with LHFPL4; leading to mutual regulation of the protein level and synaptic clustering (PubMed:29742426, PubMed:28279354). Interacts with GABRA1 (By similarity). Q69ZK9; Q69ZK9: Nlgn2; NbExp=2; IntAct=EBI-775065, EBI-775065; Q69ZK9; O14522: PTPRT; Xeno; NbExp=2; IntAct=EBI-775065, EBI-728180; Cell membrane; Single-pass type I membrane protein. Postsynaptic cell membrane Presynaptic cell membrane. Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina. Brain and arteries. Detected in the retina outer plexiform layer (at protein level). Widely expressed. Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. No obvious phenotype, but mice present subtle behavorial changes. Signaling from inhibitory synapses is impaired. In addition, mice have reduced brain volume. Mice lacking both NLGN1 and NLGN2, or NLGN2 and NLGN3, are viable, but have impaired breathing, drastically reduced reproduction rates and striking deficits in raising their offspring. Mice lacking NLGN1, NLGN2 and NLGN3 are born at the expected Mendelian rate, but die shortly after birth due to respiratory failure. They do not show a significant change in the number of synapses, but synapse function is strongly impaired. Belongs to the type-B carboxylesterase/lipase family. Sequence=BAD32437.1; Type=Erroneous initiation; Evidence=; thigmotaxis regulation of respiratory gaseous exchange by neurological system process protein binding cytoplasm plasma membrane integral component of plasma membrane cell adhesion neuron cell-cell adhesion synapse assembly jump response positive regulation of cell proliferation cell surface membrane integral component of membrane sensory perception of pain cell junction positive regulation of insulin secretion positive regulation of synaptic transmission, GABAergic social behavior protein localization to synapse locomotory exploration behavior signaling receptor activity neurexin family protein binding presynaptic membrane identical protein binding dendritic shaft synapse postsynaptic membrane synaptic vesicle endocytosis modulation of synaptic transmission synapse organization cell adhesion molecule binding neuromuscular process controlling balance positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic excitatory synapse inhibitory synapse positive regulation of dendritic spine development terminal button organization postsynaptic membrane assembly presynaptic membrane assembly gephyrin clustering involved in postsynaptic density assembly postsynaptic density protein 95 clustering positive regulation of inhibitory postsynaptic potential ribbon synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of postsynaptic specialization membrane insulin metabolic process positive regulation of protein localization to synapse positive regulation of t-SNARE clustering inhibitory synapse assembly regulation of presynapse assembly regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of synaptic vesicle clustering uc007jrx.1 uc007jrx.2 uc007jrx.3 
ENSMUST00000108639.8 Zbtb4 ENSMUST00000108639.8 zinc finger and BTB domain containing 4, transcript variant 1 (from RefSeq NM_029348.2) ENSMUST00000108639.1 ENSMUST00000108639.2 ENSMUST00000108639.3 ENSMUST00000108639.4 ENSMUST00000108639.5 ENSMUST00000108639.6 ENSMUST00000108639.7 Kiaa1538 NM_029348 Q3UHT8 Q5F293 Q69ZH0 ZBTB4_MOUSE uc007jrn.1 uc007jrn.2 uc007jrn.3 uc007jrn.4 Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912). Interacts with HIPK2. Interacts with CBFA2T3. Interacts with ZBTB38. Nucleus Chromosome Note=Localizes to chromocenters. Expressed in adult and aged myogenic satellite cells. Not expressed during development, is induced during establishment of satellite cells and acquisition of quiescence. Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response to DNA damage. Sequence=BAE27769.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm chromosome cytosol regulation of transcription, DNA-templated cellular response to DNA damage stimulus methyl-CpG binding methyl-CpNpG binding nuclear body protein kinase binding protein homodimerization activity sequence-specific DNA binding negative regulation of transcription, DNA-templated metal ion binding uc007jrn.1 uc007jrn.2 uc007jrn.3 uc007jrn.4 
ENSMUST00000108653.4 Nlrp12 ENSMUST00000108653.4 NLR family, pyrin domain containing 12 (from RefSeq NM_001033431.1) E9Q5R7 ENSMUST00000108653.1 ENSMUST00000108653.2 ENSMUST00000108653.3 NAL12_MOUSE NALP12 NM_001033431 Q3UEM3 uc009eul.1 uc009eul.2 uc009eul.3 uc009eul.4 Plays an essential role as an potent mitigator of inflammation (PubMed:26521018, PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non- canonical NF-kappa-B and ERK activation pathways (PubMed:30559449). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Inhibits also the RIGI- mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation (By similarity). Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (PubMed:30212649). Interacts (via pyrin domain) with ASC. Interacts (via pyrin domain) with FAF1 (via UBA domain) (By similarity). Interacts with MAP3K14; this interaction promotes proteasomal degradation of MAP3K14 (By similarity). Interacts with NOD2; this interaction promotes degradation of NOD2 through the ubiquitin-proteasome pathway (PubMed:30559449). Interacts with HSPA1A and HSPA8 (By similarity). Interacts with HSP90AA1 (PubMed:30559449). Interacts with TRIM25; this interaction inhibits RIGI-mediated signaling pathway (By similarity). E9Q5R7; PRO_0000449623 [P0DTD1]: rep; Xeno; NbExp=2; IntAct=EBI-26583426, EBI-25475864; Cytoplasm Mainly expressed in dendritic cells (DCs) and neutrophils. NLRP12-deficient mice exhibit attenuated inflammatory responses due to significantly reduced capacity of dendritic cells to migrate to draining lymph nodes (PubMed:20861349). They also gained significantly more weight and a greater percentage of body fat than wild-type mice (PubMed:30212649). NLRP12-deficient mice also exhibit enhanced disease in a mouse model of multiple sclerosis (PubMed:26521018). During viral infection, augments host response with greater type I interferon production and RIGI protein (PubMed:30902577). Belongs to the NLRP family. nucleotide binding protein binding ATP binding cytoplasm negative regulation of signal transduction negative regulation of protein autophosphorylation negative regulation of NF-kappaB transcription factor activity dendritic cell migration regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MHC class I biosynthetic process negative regulation of interleukin-6 biosynthetic process negative regulation of Toll signaling pathway negative regulation of cytokine secretion negative regulation of interleukin-1 secretion negative regulation of inflammatory response negative regulation of ERK1 and ERK2 cascade cellular response to cytokine stimulus negative regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling nucleus uc009eul.1 uc009eul.2 uc009eul.3 uc009eul.4 
ENSMUST00000108654.3 Cd68 ENSMUST00000108654.3 Endosome membrane ; Single-pass type I membrane protein Lysosome membrane ; Single-pass type I membrane protein (from UniProt A0A0R4J1C8) A0A0R4J1C8 A0A0R4J1C8_MOUSE AK170443 Cd68 ENSMUST00000108654.1 ENSMUST00000108654.2 uc287zik.1 uc287zik.2 Endosome membrane ; Single-pass type I membrane protein Lysosome membrane ; Single-pass type I membrane protein Belongs to the LAMP family. Lacks conserved residue(s) required for the propagation of feature annotation. lysosome lysosomal membrane membrane integral component of membrane uc287zik.1 uc287zik.2 
ENSMUST00000108656.9 Sat2 ENSMUST00000108656.9 spermidine/spermine N1-acetyl transferase 2, transcript variant 1 (from RefSeq NM_026991.3) ENSMUST00000108656.1 ENSMUST00000108656.2 ENSMUST00000108656.3 ENSMUST00000108656.4 ENSMUST00000108656.5 ENSMUST00000108656.6 ENSMUST00000108656.7 ENSMUST00000108656.8 NM_026991 Q5F299 Q6P8J2 SAT2_MOUSE Sat2 Ssat2 uc007jqs.1 uc007jqs.2 uc007jqs.3 Catalyzes the N-acetylation of the amino acid thialysine (S- (2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur. May also catalyze acetylation of polyamines, such as norspermidine, spermidine or spermine. However, ability to acetylate polyamines is weak, suggesting that it does not act as a diamine acetyltransferase in vivo. Reaction=acetyl-CoA + S-(2-aminoethyl)-L-cysteine = CoA + H(+) + S-(2- acetamidoethyl)-L-cysteine; Xref=Rhea:RHEA:64804, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:156132, ChEBI:CHEBI:156134; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64805; Evidence=; Reaction=acetyl-CoA + an alkane-alpha,omega-diamine = an N- acetylalkane-alpha,omega-diamine + CoA + H(+); Xref=Rhea:RHEA:11116, Rhea:RHEA-COMP:9766, Rhea:RHEA-COMP:9767, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:70977, ChEBI:CHEBI:70988; EC=2.3.1.57; Evidence=; Homodimer. Cytoplasm Note=Intracellular organelles. Belongs to the acetyltransferase family. diamine N-acetyltransferase activity cytoplasm N-acetyltransferase activity spermine metabolic process spermidine metabolic process putrescine catabolic process transferase activity transferase activity, transferring acyl groups spermidine binding spermidine acetylation spermine acetylation putrescine acetylation identical protein binding nor-spermidine metabolic process uc007jqs.1 uc007jqs.2 uc007jqs.3 
ENSMUST00000108658.10 Trp53 ENSMUST00000108658.10 transformation related protein 53, transcript variant 1 (from RefSeq NM_011640.3) ENSMUST00000108658.1 ENSMUST00000108658.2 ENSMUST00000108658.3 ENSMUST00000108658.4 ENSMUST00000108658.5 ENSMUST00000108658.6 ENSMUST00000108658.7 ENSMUST00000108658.8 ENSMUST00000108658.9 NM_011640 Q549C9 Q549C9_MOUSE Trp53 p53 uc007jqn.1 uc007jqn.2 uc007jqn.3 uc007jqn.4 This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Note=Binds 1 zinc ion per subunit. Binds DNA as a homotetramer. Cytoplasm Nucleus Endoplasmic reticulum Mitochondrion matrix Nucleus, PML body Belongs to the p53 family. DNA strand renaturation chromatin nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding RNA polymerase II transcription factor binding TFIID-class transcription factor binding RNA polymerase II activating transcription factor binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protease binding p53 binding hematopoietic progenitor cell differentiation positive regulation of leukocyte migration DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding mRNA 3'-UTR binding copper ion binding ATP binding nucleus nucleoplasm transcription factor complex transcription factor TFIID complex nucleolus cytoplasm mitochondrion cytosol nucleotide-excision repair regulation of transcription, DNA-templated autophagy apoptotic process cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator response to oxidative stress ER overload response cell cycle cell cycle arrest Ras protein signal transduction multicellular organism development aging cell aging protein C-terminus binding protein localization transcription factor binding negative regulation of cell proliferation mRNA transcription response to UV response to inorganic substance response to metal ion response to X-ray response to UV-B response to organonitrogen compound response to gamma radiation positive regulation of gene expression response to organic cyclic compound viral process nuclear matrix nuclear body PML body enzyme binding protein kinase binding protein phosphatase binding negative regulation of cell growth DNA damage response, signal transduction by p53 class mediator receptor tyrosine kinase binding response to caffeine chromatin assembly mitotic G1 DNA damage checkpoint ubiquitin protein ligase binding positive regulation of protein oligomerization response to retinoic acid macromolecular complex response to vitamin B3 response to cytokine cellular response to heat cellular response to reactive oxygen species cellular response to UV histone acetyltransferase binding cellular response to drug positive regulation of transcription from RNA polymerase II promoter in response to stress wound healing cellular response to glucose starvation response to drug intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator identical protein binding protein homodimerization activity histone deacetylase binding regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process response to amino acid sequence-specific DNA binding protein self-association transcription regulatory region DNA binding response to ethanol positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of RNA polymerase II transcriptional preinitiation complex assembly positive regulation of transcription from RNA polymerase II promoter response to antibiotic metal ion binding protein heterodimerization activity protein N-terminus binding negative regulation of fibroblast proliferation bone marrow development negative regulation of smooth muscle cell proliferation chaperone binding RNA polymerase II transcriptional preinitiation complex assembly protein tetramerization protein homotetramerization regulation of intracellular pH protein phosphatase 2A binding negative regulation of telomerase activity response to hyperoxia hematopoietic stem cell differentiation macromolecular complex assembly positive regulation of cell cycle arrest cellular response to organonitrogen compound cellular response to hypoxia cellular response to ionizing radiation cellular response to gamma radiation signal transduction by p53 class mediator intrinsic apoptotic signaling pathway by p53 class mediator cellular response to actinomycin D positive regulation of release of cytochrome c from mitochondria replicative senescence oxidative stress-induced premature senescence RNA polymerase II transcription factor complex oligodendrocyte apoptotic process MDM2/MDM4 family protein binding disordered domain specific binding positive regulation of execution phase of apoptosis positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of hydrogen peroxide-induced cell death positive regulation of production of miRNAs involved in gene silencing by miRNA regulation of transcription from RNA polymerase II promoter in response to DNA damage promoter-specific chromatin binding negative regulation of DNA biosynthetic process positive regulation of reactive oxygen species metabolic process positive regulation of intrinsic apoptotic signaling pathway uc007jqn.1 uc007jqn.2 uc007jqn.3 uc007jqn.4 
ENSMUST00000108659.2 Dnah2 ENSMUST00000108659.2 dynein, axonemal, heavy chain 2, transcript variant 1 (from RefSeq NM_001419927.1) D3Z667 D3Z667_MOUSE Dnah2 Dnahc2 ENSMUST00000108659.1 NM_001419927 uc007jqg.1 uc007jqg.2 Belongs to the dynein heavy chain family. microtubule motor activity ATP binding microtubule-based movement dynein complex uc007jqg.1 uc007jqg.2 
ENSMUST00000108661.8 Chd3 ENSMUST00000108661.8 chromodomain helicase DNA binding protein 3 (from RefSeq NM_146019.4) B1AR17 B1AR17_MOUSE Chd3 ENSMUST00000108661.1 ENSMUST00000108661.2 ENSMUST00000108661.3 ENSMUST00000108661.4 ENSMUST00000108661.5 ENSMUST00000108661.6 ENSMUST00000108661.7 NM_146019 uc029rmi.1 uc029rmi.2 uc029rmi.3 uc029rmi.4 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Belongs to the SNF2/RAD54 helicase family. protein binding ATP binding nucleus nucleoplasm nucleolus cytoplasm centrosome microtubule organizing center chromatin assembly or disassembly spindle organization centrosome cycle NuRD complex ATPase activity DNA duplex unwinding double-stranded DNA-dependent ATP-dependent DNA helicase activity ATP-dependent chromatin remodeling metal ion binding nucleosome-dependent ATPase activity uc029rmi.1 uc029rmi.2 uc029rmi.3 uc029rmi.4 
ENSMUST00000108666.8 Aurkb ENSMUST00000108666.8 Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (By similarity). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (By similarity). Required for central/midzone spindle assembly and cleavage furrow formation (By similarity). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (By similarity). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (By similarity). Phosphorylation of INCENP leads to increased AURKB activity (By similarity). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (By similarity). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (By similarity). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863). AURKB is also required for kinetochore localization of BUB1 and SGO1 (By similarity). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (By similarity). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B- cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (PubMed:24034696). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (By similarity). Phosphorylates KRT5 during anaphase and telophase (PubMed:29518391). (from UniProt O70126) AURKB_MOUSE Aik2 Aim1 Airk2 Ark2 BC003261 ENSMUST00000108666.1 ENSMUST00000108666.2 ENSMUST00000108666.3 ENSMUST00000108666.4 ENSMUST00000108666.5 ENSMUST00000108666.6 ENSMUST00000108666.7 O70126 Q61882 Q8C6C1 Stk1 Stk12 Stk5 uc287zeo.1 uc287zeo.2 Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (By similarity). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (By similarity). Required for central/midzone spindle assembly and cleavage furrow formation (By similarity). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (By similarity). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (By similarity). Phosphorylation of INCENP leads to increased AURKB activity (By similarity). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (By similarity). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (By similarity). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863). AURKB is also required for kinetochore localization of BUB1 and SGO1 (By similarity). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (By similarity). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B- cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (PubMed:24034696). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (By similarity). Phosphorylates KRT5 during anaphase and telophase (PubMed:29518391). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Activity is greatly increased when AURKB is within the CPC complex. In particular, AURKB-phosphorylated INCENP acts as an activator of AURKB. Positive feedback between HASPIN and AURKB contributes to CPC localization. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist. Associates with RACGAP1 during M phase. Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3, SEPTIN1, SIRT2 and TACC1. Interacts with SPDYC; this interaction may be required for proper localization of active, Thr-237- phosphorylated AURKB form during prometaphase and metaphase. Interacts with p53/TP53. Interacts (via the middle kinase domain) with NOC2L (via the N- and C-terminus domains). Interacts with TTC28 (By similarity). Interacts with RNF2/RING1B (PubMed:24034696). Nucleus Chromosome Chromosome, centromere Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Midbody Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the midbody. Proper localization of the active, Thr-237- phosphorylated form during metaphase may be dependent upon interaction with SPDYC. Colocalized with SIRT2 during cytokinesis with the midbody. Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis- specific histone phosphorylations H3pT3 and H2ApT12. Expressed in testis, intestine and spleen. All of them are tissues that contain a large number of proliferating cells. Expressed during S phase, in a cell-cycle-dependent fashion. Strongly expressed in 8.5 and 12.5 dpc. The phosphorylation of Thr-237 requires the binding to INCENP and occurs by means of an autophosphorylation mechanism. Thr-237 phosphorylation is indispensable for the AURKB kinase activity. Acetylated at Lys-220 by KAT5 at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis. Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. Deubiquitinated by USP35; inhibiting CDH1-mediated degradation of AURKB. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. negative regulation of transcription from RNA polymerase II promoter nucleotide binding chromosome, centromeric region kinetochore condensed chromosome, centromeric region condensed nuclear chromosome, centromeric region negative regulation of B cell apoptotic process protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm chromosome cytoplasm spindle cytoskeleton spindle microtubule protein phosphorylation cell cycle spindle organization mitotic spindle organization mitotic spindle assembly checkpoint aging cell proliferation abscission chromocenter kinase activity phosphorylation transferase activity kinase binding midbody spindle pole centrosome negative regulation of protein binding chromosome passenger complex positive regulation of telomere maintenance via telomerase regulation of cytokinesis negative regulation of cytokinesis positive regulation of cytokinesis protein localization to kinetochore cellular response to UV histone serine kinase activity cleavage furrow formation histone H3-S28 phosphorylation mitotic cytokinesis checkpoint metal ion binding spindle midzone mitotic spindle midzone assembly cell division positive regulation of telomerase activity positive regulation of telomere capping mitotic spindle midzone uc287zeo.1 uc287zeo.2 
ENSMUST00000108671.2 Arhgef15 ENSMUST00000108671.2 Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse- promoting activity of EPHB2. (from UniProt Q5FWH6) ARHGF_MOUSE BC089365 ENSMUST00000108671.1 Kiaa0915 Q14B44 Q5FWH6 Q69ZV7 uc287zdn.1 uc287zdn.2 Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse- promoting activity of EPHB2. Interacts with EPHA4 (By similarity). Interacts with EPHB2. Q5FWH6-2; P54763: Ephb2; NbExp=3; IntAct=EBI-2943608, EBI-537711; Cell projection, dendrite Note=Expressed exclusively in dendrites of the developing hippocampus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5FWH6-1; Sequence=Displayed; Name=2; IsoId=Q5FWH6-2; Sequence=VSP_036209, VSP_036210; At P12, expressed is detected in the CA1 region and the dentate gyrus of the hippocampus. Highest levels in hippocampus are found at postnatal day 3 prior to maximal synapse formation and decrease as synapse formation peaks in the postnatal period (at protein level). Phosphorylated on tyrosine residues upon EFNA1 stimulation. EPHB2- dependent phosphorylation at Tyr-361 triggers UBE3A-mediated ubiquitination. Ubiquitinated; UBE3A-mediated ubiquitination and degradation by the proteasome promotes EFNB1-dependent synapse formation. Significant decrease in RHOA activation in brain extracts. In a mouse model of Angelman syndrome where Ube3a levels are reduced, levels of Arhgef15 are significantly increased and ubiquitination is reduced compared to wild-type litter mates. guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity protein binding cytoplasm dendrite regulation of Rho protein signal transduction cell projection positive regulation of GTPase activity regulation of catalytic activity positive regulation of stress fiber assembly retina vasculature morphogenesis in camera-type eye negative regulation of synapse maturation uc287zdn.1 uc287zdn.2 
ENSMUST00000108674.9 Ntn1 ENSMUST00000108674.9 Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity). (from UniProt O09118) B1ARR0 BC141294 ENSMUST00000108674.1 ENSMUST00000108674.2 ENSMUST00000108674.3 ENSMUST00000108674.4 ENSMUST00000108674.5 ENSMUST00000108674.6 ENSMUST00000108674.7 ENSMUST00000108674.8 NET1_MOUSE O09118 Q60832 Q9QY50 uc287zcl.1 uc287zcl.2 Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity). Binds to its receptors; DCC, UNC5A, UNC5B, UNC5C and probably UNC5D (By similarity). Binds to its receptor; DSCAM (PubMed:18585357). Interacts with APP (PubMed:27068745). O09118; Q8K1S3-1: Unc5b; NbExp=4; IntAct=EBI-1798844, EBI-11658250; Secreted Cytoplasm Note=Mainly secreted. In the embryo, widely expressed in the developing nervous system and in mesodermal tissues. neuron migration T cell mediated immunity cytokine activity extracellular matrix structural constituent protein binding extracellular region basement membrane cytoplasm apoptotic process substrate-dependent cell migration, cell extension nuclear migration Ras protein signal transduction axonogenesis axon guidance motor neuron axon guidance positive regulation of cell proliferation animal organ morphogenesis tissue development dendrite development B cell mediated immunity regulation of cell migration negative regulation of axon extension mammary gland development extracellular matrix Cdc42 protein signal transduction anterior/posterior axon guidance B cell proliferation inner ear morphogenesis positive regulation of axon extension regulation of synapse assembly mammary gland duct morphogenesis chemorepulsion of axon cell periphery cell-cell adhesion positive regulation of cell motility uc287zcl.1 uc287zcl.2 
ENSMUST00000108681.9 Gas7 ENSMUST00000108681.9 growth arrest specific 7, transcript variant 5 (from RefSeq NM_001402818.1) ENSMUST00000108681.1 ENSMUST00000108681.2 ENSMUST00000108681.3 ENSMUST00000108681.4 ENSMUST00000108681.5 ENSMUST00000108681.6 ENSMUST00000108681.7 ENSMUST00000108681.8 F6QB26 F6QB26_MOUSE Gas7 NM_001402818 uc287zbk.1 uc287zbk.2 uc287zbk.1 uc287zbk.2 
ENSMUST00000108684.8 Myh13 ENSMUST00000108684.8 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (from UniProt B1AR69) AK136634 B1AR69 B1AR69_MOUSE ENSMUST00000108684.1 ENSMUST00000108684.2 ENSMUST00000108684.3 ENSMUST00000108684.4 ENSMUST00000108684.5 ENSMUST00000108684.6 ENSMUST00000108684.7 Myh13 uc287zbg.1 uc287zbg.2 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. nucleotide binding motor activity actin binding ATP binding cellular response to starvation myosin complex myofibril actin filament binding uc287zbg.1 uc287zbg.2 
ENSMUST00000108689.8 Myh3 ENSMUST00000108689.8 myosin, heavy polypeptide 3, skeletal muscle, embryonic (from RefSeq NM_001099635.1) ENSMUST00000108689.1 ENSMUST00000108689.2 ENSMUST00000108689.3 ENSMUST00000108689.4 ENSMUST00000108689.5 ENSMUST00000108689.6 ENSMUST00000108689.7 MYH3_MOUSE Myhse NM_001099635 P13541 Q3V183 Q5SUD4 uc007jlw.1 uc007jlw.2 uc007jlw.3 Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. [provided by RefSeq, Sep 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164141 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## Muscle contraction. Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents a conventional myosin. This protein should not be confused with the unconventional myosin-3 (MYO3). microfilament motor activity nucleotide binding skeletal muscle contraction motor activity actin binding calmodulin binding ATP binding cytoplasm myosin complex myofibril myosin filament ATPase activity, coupled contractile fiber ATP metabolic process actin filament binding uc007jlw.1 uc007jlw.2 uc007jlw.3 
ENSMUST00000108690.10 Sco1 ENSMUST00000108690.10 Belongs to the SCO1/2 family. (from UniProt Q5SUD5) AK011251 ENSMUST00000108690.1 ENSMUST00000108690.2 ENSMUST00000108690.3 ENSMUST00000108690.4 ENSMUST00000108690.5 ENSMUST00000108690.6 ENSMUST00000108690.7 ENSMUST00000108690.8 ENSMUST00000108690.9 Q5SUD5 Q5SUD5_MOUSE Sco1 uc287zap.1 uc287zap.2 Belongs to the SCO1/2 family. cell cell redox homeostasis uc287zap.1 uc287zap.2 
ENSMUST00000108702.8 Pmp22 ENSMUST00000108702.8 peripheral myelin protein 22, transcript variant 14 (from RefSeq NM_001404281.1) ENSMUST00000108702.1 ENSMUST00000108702.2 ENSMUST00000108702.3 ENSMUST00000108702.4 ENSMUST00000108702.5 ENSMUST00000108702.6 ENSMUST00000108702.7 NM_001404281 Pmp22 Q5SXS3 Q5SXS3_MOUSE uc056ylj.1 uc056ylj.2 uc056ylj.3 Might be involved in growth regulation, and in myelinization in the peripheral nervous system. Cell membrane ; Multi-pass membrane protein Membrane ; Multi- pass membrane protein Belongs to the PMP-22/EMP/MP20 family. Lacks conserved residue(s) required for the propagation of feature annotation. plasma membrane bicellular tight junction cell death negative regulation of cell proliferation negative regulation of neuron projection development membrane integral component of membrane cell differentiation bleb assembly myelination compact myelin uc056ylj.1 uc056ylj.2 uc056ylj.3 
ENSMUST00000108712.8 Epn2 ENSMUST00000108712.8 Belongs to the epsin family. (from UniProt Q5NCM5) AK173093 ENSMUST00000108712.1 ENSMUST00000108712.2 ENSMUST00000108712.3 ENSMUST00000108712.4 ENSMUST00000108712.5 ENSMUST00000108712.6 ENSMUST00000108712.7 Epn2 Q5NCM5 Q5NCM5_MOUSE uc287yua.1 uc287yua.2 Belongs to the epsin family. endocytosis clathrin coat of endocytic vesicle uc287yua.1 uc287yua.2 
ENSMUST00000108716.8 Aldh3a1 ENSMUST00000108716.8 aldehyde dehydrogenase family 3, subfamily A1, transcript variant 2 (from RefSeq NM_001112725.1) AL3A1_MOUSE Ahd-4 Ahd4 Aldh3 Aldh4 B1ATI7 ENSMUST00000108716.1 ENSMUST00000108716.2 ENSMUST00000108716.3 ENSMUST00000108716.4 ENSMUST00000108716.5 ENSMUST00000108716.6 ENSMUST00000108716.7 NM_001112725 P47739 Q9R203 uc007jhd.1 uc007jhd.2 uc007jhd.3 uc007jhd.4 uc007jhd.5 ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:25286108). Preferentially oxidizes aromatic aldehyde substrates (PubMed:11784860). Comprises about 50 percent of corneal epithelial soluble proteins (PubMed:11784860). May play a role in preventing corneal damage caused by ultraviolet light (PubMed:10376761). Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.5; Evidence=; Reaction=H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate; Xref=Rhea:RHEA:44100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:25646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Homodimer. Cytoplasm Constitutively expressed in cornea, stomach, skin, bladder and lungs. Lowest expression levels in lungs and bladder. There are two alleles, Ald3a1a and Ald3a1c. Ald3a1c codes for a low activity enzyme and is associated with extensive corneal clouding after exposure to ultraviolet light. Ald3a1a encodes the high activity enzyme. Belongs to the aldehyde dehydrogenase family. response to hypoxia 3-chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity aldehyde dehydrogenase [NAD(P)+] activity cytoplasm endoplasmic reticulum cytosol plasma membrane cellular aldehyde metabolic process aging response to nutrient alcohol dehydrogenase (NADP+) activity positive regulation of cell proliferation response to organic cyclic compound integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor benzaldehyde dehydrogenase (NAD+) activity response to drug response to glucocorticoid response to cAMP oxidation-reduction process uc007jhd.1 uc007jhd.2 uc007jhd.3 uc007jhd.4 uc007jhd.5 
ENSMUST00000108718.2 Dhrs7b ENSMUST00000108718.2 dehydrogenase/reductase 7B, transcript variant 1 (from RefSeq NM_001172112.1) Dhrs7b ENSMUST00000108718.1 NM_001172112 Z4YKT6 Z4YKT6_MOUSE uc287yrx.1 uc287yrx.2 Putative oxidoreductase. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Belongs to the short-chain dehydrogenases/reductases (SDR) family. membrane integral component of membrane oxidoreductase activity oxidation-reduction process uc287yrx.1 uc287yrx.2 
ENSMUST00000108721.9 Atpaf2 ENSMUST00000108721.9 ATP synthase mitochondrial F1 complex assembly factor 2, transcript variant 4 (from RefSeq NR_157083.2) ATPF2_MOUSE ENSMUST00000108721.1 ENSMUST00000108721.2 ENSMUST00000108721.3 ENSMUST00000108721.4 ENSMUST00000108721.5 ENSMUST00000108721.6 ENSMUST00000108721.7 ENSMUST00000108721.8 NR_157083 Q8BP08 Q91YY4 uc007jfv.1 uc007jfv.2 uc007jfv.3 uc007jfv.4 uc007jfv.5 May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase). Interacts with ATP5F1A. Interacts with FMC1. Mitochondrion Belongs to the ATP12 family. Sequence=BAC37311.1; Type=Erroneous initiation; Evidence=; Sequence=CAI24077.1; Type=Erroneous initiation; Evidence=; molecular_function mitochondrion cytosol biological_process nuclear speck proton-transporting ATP synthase complex assembly uc007jfv.1 uc007jfv.2 uc007jfv.3 uc007jfv.4 uc007jfv.5 
ENSMUST00000108723.9 Drc3 ENSMUST00000108723.9 dynein regulatory complex subunit 3 (from RefSeq NM_029044.2) DRC3_MOUSE ENSMUST00000108723.1 ENSMUST00000108723.2 ENSMUST00000108723.3 ENSMUST00000108723.4 ENSMUST00000108723.5 ENSMUST00000108723.6 ENSMUST00000108723.7 ENSMUST00000108723.8 Lrrc48 NM_029044 Q9D5E4 uc007jfu.1 uc007jfu.2 uc007jfu.3 Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Component of the nexin-dynein regulatory complex (N-DRC). Interacts with DRC1 (By similarity). Interacts with TCTE1/DRC5 (PubMed:28630322). Interacts with DRC7 (PubMed:31961863). Cytoplasm, cytoskeleton, cilium axoneme Cell projection, cilium Cytoplasm, cytoskeleton, flagellum axoneme Cell projection, cilium, flagellum Belongs to the DRC3 family. protein binding cytoplasm cytoskeleton cilium axoneme biological_process motile cilium cell projection uc007jfu.1 uc007jfu.2 uc007jfu.3 
ENSMUST00000108745.8 Ccdc7b ENSMUST00000108745.8 coiled-coil domain containing 7B, transcript variant 2 (from RefSeq NM_029292.3) 1700008F21Rik B9EJU4 B9EJU4_MOUSE Ccdc7b ENSMUST00000108745.1 ENSMUST00000108745.2 ENSMUST00000108745.3 ENSMUST00000108745.4 ENSMUST00000108745.5 ENSMUST00000108745.6 ENSMUST00000108745.7 NM_029292 uc009oab.1 uc009oab.2 uc009oab.3 uc009oab.4 molecular_function cellular_component biological_process uc009oab.1 uc009oab.2 uc009oab.3 uc009oab.4 
ENSMUST00000108756.8 Myt1 ENSMUST00000108756.8 myelin transcription factor 1, transcript variant 1 (from RefSeq NM_008665.5) B0R0C3 B0R0C4 ENSMUST00000108756.1 ENSMUST00000108756.2 ENSMUST00000108756.3 ENSMUST00000108756.4 ENSMUST00000108756.5 ENSMUST00000108756.6 ENSMUST00000108756.7 Kiaa0835 MYT1_MOUSE NM_008665 Nzf2 O08995 Q8CFC2 Q8CFH1 uc008ons.1 uc008ons.2 uc008ons.3 uc008ons.4 This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity). Interacts with STEAP3. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=NZF-2b; IsoId=Q8CFC2-1; Sequence=Displayed; Name=2; Synonyms=NZF-2a; IsoId=Q8CFC2-2; Sequence=VSP_015720; Name=3; IsoId=Q8CFC2-3; Sequence=VSP_015721; Isoform 1 is more predominant than isoform 2 at all stages of development and adulthood. Expressed in differentiated neurons especially at higher levels in newly generated ones. Isoform 1 is detected in the earliest born neurons. At 9.5 dpc it is detected in the ventrolateral part of the spinal cord, which later become motor neurons and is also detected in the dispersed cells of the alar plate interneurons. During spinal cord development, the expression is highest in the latest born neurons (the subventricular zone). Detected in the early differentiated neurons within the neuroepithelium and the neural crest cells at 9.5 dpc. At 12.5 dpc, detected in the differentiated neurons within the forebrain, midbrain, and hindbrain. In these neurons, the expression level is highest in the latest born neurons and is also detected in the differentiated neurons of the sensory organs and the peripheral ganglia. Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence. Belongs to the MYT1 family. Sequence=BAC41451.2; Type=Erroneous initiation; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cellular glucose homeostasis DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated multicellular organism development nervous system development zinc ion binding post-embryonic development positive regulation of gene expression negative regulation of gene expression cell differentiation endocrine pancreas development regulation of hormone metabolic process positive regulation of transcription from RNA polymerase II promoter metal ion binding diaphragm development regulation of insulin secretion involved in cellular response to glucose stimulus uc008ons.1 uc008ons.2 uc008ons.3 uc008ons.4 
ENSMUST00000108759.3 Slc35f3 ENSMUST00000108759.3 solute carrier family 35, member F3, transcript variant 2 (from RefSeq NM_175434.3) ENSMUST00000108759.1 ENSMUST00000108759.2 NM_175434 Q1LZI2 Q8BL51 S35F3_MOUSE uc009nyt.1 uc009nyt.2 uc009nyt.3 uc009nyt.4 Mediates thiamine transport. Reaction=thiamine(in) = thiamine(out); Xref=Rhea:RHEA:34919, ChEBI:CHEBI:18385; Evidence=; Membrane ; Multi-pass membrane protein Belongs to the SLC35F solute transporter family. molecular_function cellular_component thiamine transport membrane integral component of membrane uc009nyt.1 uc009nyt.2 uc009nyt.3 uc009nyt.4 
ENSMUST00000108772.8 Rgs19 ENSMUST00000108772.8 regulator of G-protein signaling 19, transcript variant 7 (from RefSeq NM_001291210.1) ENSMUST00000108772.1 ENSMUST00000108772.2 ENSMUST00000108772.3 ENSMUST00000108772.4 ENSMUST00000108772.5 ENSMUST00000108772.6 ENSMUST00000108772.7 NM_001291210 Q8BFU4 Q8BFU4_MOUSE Rgs19 uc008onf.1 uc008onf.2 uc008onf.3 uc008onf.4 uc008onf.1 uc008onf.2 uc008onf.3 uc008onf.4 
ENSMUST00000108777.10 Jmjd4 ENSMUST00000108777.10 jumonji domain containing 4, transcript variant 1 (from RefSeq NM_178659.6) ENSMUST00000108777.1 ENSMUST00000108777.2 ENSMUST00000108777.3 ENSMUST00000108777.4 ENSMUST00000108777.5 ENSMUST00000108777.6 ENSMUST00000108777.7 ENSMUST00000108777.8 ENSMUST00000108777.9 JMJD4_MOUSE NM_178659 Q4QQM9 Q80ZI5 Q8BFT6 Q8BPV8 uc007jdu.1 uc007jdu.2 uc007jdu.3 uc007jdu.4 Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1 (By similarity). Not essential for embryonic stem cell (ESC) maintenance and the embryonic and postnatal development (PubMed:27147518). Reaction=2-oxoglutarate + L-lysyl-[protein] + O2 = 4-hydroxy-L-lysyl- [protein] + CO2 + succinate; Xref=Rhea:RHEA:57156, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:15084, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:141495; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Interacts with ETF1 (By similarity). Interacts with the ETF1- GSPT1 complex (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BFT6-1; Sequence=Displayed; Name=3; IsoId=Q8BFT6-3; Sequence=VSP_026326; Name=4; IsoId=Q8BFT6-4; Sequence=VSP_026327, VSP_026328; Mice are born at the expected Mendelian rate and are healthy, fertile and physiologically normal (PubMed:27147518). Embryonic stem cells (ESCs) exhibit normal colony morphology and cell proliferation rates and maintain normal expression of pluripotent genes (PubMed:27147518). cytoplasm oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors protein hydroxylation positive regulation of translational termination metal ion binding dioxygenase activity oxidation-reduction process uc007jdu.1 uc007jdu.2 uc007jdu.3 uc007jdu.4 
ENSMUST00000108783.4 Wnt9a ENSMUST00000108783.4 wingless-type MMTV integration site family, member 9A (from RefSeq NM_139298.2) ENSMUST00000108783.1 ENSMUST00000108783.2 ENSMUST00000108783.3 NM_139298 Q8R5M2 WNT9A_MOUSE Wnt14 uc007jdq.1 uc007jdq.2 Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development (PubMed:16818445). Plays a redundant role in maintaining joint integrity (PubMed:16818445). Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids. Secreted, extracellular space, extracellular matrix Secreted Expressed in adult brain, lung, skeletal muscle, heart, and 17-day embryo. Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. Mutant mice die during the first 12 hours after birth. Heart, lung, liver, intestinal tract, kidney and brain appear grossly normal, but the mice display skeletal abnormalities, with slightly shortened long bones in their limbs. The region of bone mineralization is reduced in scapula, humerus, ileum and femur. Besides, hyoid bone and atlas are hypoplastic. In the scull, the supraoccipital bone shows reduced mineralization, with increased distance between the frontal bones. The basioccipital bone displays an abnormal shape and is smaller than in wild-type. Ectopic cartilage nodules are detected within the skull midline sutures. Ectopic cartilaginous material is detected in the interfrontal and sagittal suture regions between the frontal and parietal bones. In neonate forelimbs, the synovial fold contains cells with a chondrocyte-like appearance. Mutant mice display also partial joint fusions between the navicular and intermediate cuneiform tarsal elements in the foot, and between wrist carpal elements. Belongs to the Wnt family. receptor binding frizzled binding protein binding extracellular region extracellular space mitotic cell cycle checkpoint multicellular organism development negative regulation of cell proliferation Wnt signaling pathway neuron differentiation negative regulation of chondrocyte differentiation embryonic forelimb morphogenesis negative regulation of cysteine-type endopeptidase activity involved in apoptotic process cell fate commitment positive regulation of cell differentiation positive regulation of smoothened signaling pathway receptor agonist activity embryonic skeletal system morphogenesis anatomical structure development canonical Wnt signaling pathway negative regulation of cell death negative regulation of cartilage development uc007jdq.1 uc007jdq.2 
ENSMUST00000108789.9 Zfp512b ENSMUST00000108789.9 zinc finger protein 512B, transcript variant 11 (from RefSeq NM_001409737.1) B7ZCR6 B7ZCR6_MOUSE ENSMUST00000108789.1 ENSMUST00000108789.2 ENSMUST00000108789.3 ENSMUST00000108789.4 ENSMUST00000108789.5 ENSMUST00000108789.6 ENSMUST00000108789.7 ENSMUST00000108789.8 NM_001409737 Zfp512b uc008omv.1 uc008omv.2 uc008omv.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding nucleus biological_process uc008omv.1 uc008omv.2 uc008omv.3 
ENSMUST00000108790.2 Gjc2 ENSMUST00000108790.2 gap junction protein, gamma 2, transcript variant 1 (from RefSeq NM_080454.4) CXG2_MOUSE ENSMUST00000108790.1 Gja12 NM_080454 Q6TLV2 Q8BQS2 Q8BQU6 Q9EPM1 uc007jdf.1 uc007jdf.2 uc007jdf.3 uc007jdf.4 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. A connexon is composed of a hexamer of connexins. Interacts with TJP1. Cell membrane ; Multi-pass membrane protein Cell junction, gap junction Mainly expressed by oligodendrocytes in the central nervous system (at protein level). Expression starts after birth in the central nervous system and parallels myelination process. Mice display myelination abnormalities characterized by extracellular vacuolation along nerve fibers. Mice lacking both Gja12 and Gjb1 display a more severe demyelination phenotype associated with oligodendrocyte death. These mice develop action tremors, tonic seizures, sporadic convulsions and loss of consciousness preceding death in the sixth week after birth. Belongs to the connexin family. Gamma-type subfamily. It is uncertain whether Met-1 or Met-4 is the initiator. Sequence=BAC32806.1; Type=Erroneous initiation; Evidence=; Sequence=CAC19434.1; Type=Erroneous initiation; Evidence=; regulation of protein phosphorylation gap junction channel activity plasma membrane gap junction connexin complex cell communication cell-cell signaling brain development response to toxic substance positive regulation of gene expression cell communication by electrical coupling membrane integral component of membrane cell junction paranode region of axon neuronal cell body perikaryon myelin sheath transmembrane transport positive regulation of oligodendrocyte progenitor proliferation gap junction channel activity involved in cell communication by electrical coupling positive regulation of calcium ion transmembrane transport proximal neuron projection negative regulation of G1/S transition of mitotic cell cycle uc007jdf.1 uc007jdf.2 uc007jdf.3 uc007jdf.4 
ENSMUST00000108800.8 Tpd52l2 ENSMUST00000108800.8 tumor protein D52-like 2, transcript variant 22 (from RefSeq NR_176048.1) ENSMUST00000108800.1 ENSMUST00000108800.2 ENSMUST00000108800.3 ENSMUST00000108800.4 ENSMUST00000108800.5 ENSMUST00000108800.6 ENSMUST00000108800.7 NR_176048 Q3TUJ9 Q3TUJ9_MOUSE Tpd52l2 uc008omo.1 uc008omo.2 uc008omo.3 uc008omo.4 Belongs to the TPD52 family. uc008omo.1 uc008omo.2 uc008omo.3 uc008omo.4 
ENSMUST00000108817.5 H2ac25 ENSMUST00000108817.5 H2A clustered histone 25 (from RefSeq NM_178218.4) ENSMUST00000108817.1 ENSMUST00000108817.2 ENSMUST00000108817.3 ENSMUST00000108817.4 H2A3_MOUSE H2ac25 H2aw Hist3h2a NM_178218 Q8BFU2 uc007jct.1 uc007jct.2 uc007jct.3 uc007jct.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Chromosome Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization nucleosome disassembly protein heterodimerization activity UV-damage excision repair uc007jct.1 uc007jct.2 uc007jct.3 uc007jct.4 
ENSMUST00000108821.8 Lypd8l ENSMUST00000108821.8 Lypd8l (from geneSymbol) 2210407C18Rik BC019553 ENSMUST00000108821.1 ENSMUST00000108821.2 ENSMUST00000108821.3 ENSMUST00000108821.4 ENSMUST00000108821.5 ENSMUST00000108821.6 ENSMUST00000108821.7 Ep1 Lypd8l Q6YI28 Q6YI28_MOUSE uc287yki.1 uc287yki.2 molecular_function cellular_component response to bacterium uc287yki.1 uc287yki.2 
ENSMUST00000108825.2 Gm12253 ENSMUST00000108825.2 predicted gene 12253 (from RefSeq NM_001045542.1) ENSMUST00000108825.1 Gm12253 NM_001045542 Q5NC48 Q5NC48_MOUSE uc007jbm.1 uc007jbm.2 molecular_function cellular_component biological_process uc007jbm.1 uc007jbm.2 
ENSMUST00000108826.3 Lypd8 ENSMUST00000108826.3 LY6/PLAUR domain containing 8, transcript variant 2 (from RefSeq NM_027339.3) ENSMUST00000108826.1 ENSMUST00000108826.2 LYPD8_MOUSE Lypd8 NM_027339 Q9D7S0 uc007jbk.1 uc007jbk.2 uc007jbk.3 This gene encodes a member of the Ly6/PLAUR family of cysteine-rich proteins that plays an important role in the protection of colonic epithelium from flagellated microbiota. The encoded protein undergoes proteolytic processing to generate a mature, glycosylphosphatidylinositol-anchored protein that is localized to the apical surface of the colonic epithelial cells. Mice lacking the encoded protein are sensitive to chemically induced intestinal inflammation. [provided by RefSeq, Aug 2016]. Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis. Cell membrane ; Lipid-anchor, GPI- anchor Secreted Note=Secreted into the lumen of the colon following cleavage of the GPI-anchor. Specifically present in enterocytes located at the uppermost epithelial layer of the colon (at protein level). Exclusively expressed in the large intestine: specifically expressed on the apical surface of epithelial cells located at the uppermost layer of the colonic gland. Highly N-glycosylated. Not O-glycosylated. GPI-anchored. The GPI-anchor is cleaved, leading to secretion into the colonic lumen. Mice are highly sensitive to intestinal inflammation induced by dextran sulfate sodium (DSS), due to the presence of bacteria in the inner mucus layer. Mice are healthy when raised in a specific-pathogen-free environment, in which bacterial contamination was strictly controlled. Belongs to the CNF-like-inhibitor family. molecular_function extracellular region extracellular space plasma membrane membrane anchored component of membrane defense response to Gram-negative bacterium uc007jbk.1 uc007jbk.2 uc007jbk.3 
ENSMUST00000108834.3 4930438A08Rik ENSMUST00000108834.3 RIKEN cDNA 4930438A08 gene (from RefSeq NM_001374705.1) 4930438A08Rik ENSMUST00000108834.1 ENSMUST00000108834.2 NM_001374705 Q5SPH3 Q5SPH3_MOUSE uc287yjb.1 uc287yjb.2 Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Secreted Belongs to the flavin monoamine oxidase family. L-amino-acid oxidase activity cellular_component cellular amino acid catabolic process oxidoreductase activity oxidation-reduction process uc287yjb.1 uc287yjb.2 
ENSMUST00000108835.2 Fndc11 ENSMUST00000108835.2 fibronectin type III domain containing 11, transcript variant 2 (from RefSeq NM_001379472.1) A2AS00 A2AS00_MOUSE BC051628 ENSMUST00000108835.1 Fndc11 NM_001379472 uc290dmd.1 uc290dmd.2 uc290dmd.1 uc290dmd.2 
ENSMUST00000108838.5 Pcbp2 ENSMUST00000108838.5 poly(rC) binding protein 2, transcript variant 16 (from RefSeq NM_001411548.1) ENSMUST00000108838.1 ENSMUST00000108838.2 ENSMUST00000108838.3 ENSMUST00000108838.4 NM_001411548 Pcbp2 Q3TT81 Q3TT81_MOUSE uc007xwb.1 uc007xwb.2 uc007xwb.3 uc007xwb.4 uc007xwb.5 nucleic acid binding RNA binding uc007xwb.1 uc007xwb.2 uc007xwb.3 uc007xwb.4 uc007xwb.5 
ENSMUST00000108849.8 Mfap3 ENSMUST00000108849.8 microfibrillar-associated protein 3, transcript variant 2 (from RefSeq NM_180599.1) A0A0R4J1C7 A0A0R4J1C7_MOUSE ENSMUST00000108849.1 ENSMUST00000108849.2 ENSMUST00000108849.3 ENSMUST00000108849.4 ENSMUST00000108849.5 ENSMUST00000108849.6 ENSMUST00000108849.7 Mfap3 NM_180599 uc007izy.1 uc007izy.2 uc007izy.3 membrane integral component of membrane uc007izy.1 uc007izy.2 uc007izy.3 
ENSMUST00000108857.2 Atox1 ENSMUST00000108857.2 antioxidant 1 copper chaperone (from RefSeq NM_009720.3) ATOX1_MOUSE Atox1 ENSMUST00000108857.1 NM_009720 O08997 Q5NCU2 uc007izj.1 uc007izj.2 uc007izj.3 Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity). Homodimer. Interacts with ATP7B. Interacts with ATP7A. Interacts (via dimer form) with SLC31A1 (via C-terminal domain); this interaction improves ATOX1 stability and controls intracellular Cu(I) levels. The heavy-metal-associated domain (HMA) coordinates a Cu(+) ion via the cysteine residues within the CXXC motif. The transfer of Cu(+) ion from ATOX1 to ATP7A involves the formation of a three-coordinate Cu(+)-bridged heterodimer where the metal is shared between the two metal binding sites of ATOX1 and ATP7A. The Cu(+) ion appears to switch between two coordination modes, forming two links with one protein and one with the other. Cisplatin, a chemotherapeutic drug, can bind the CXXC motif and hinder the release of Cu(+) ion. Belongs to the ATX1 family. copper ion binding cytosol ion transport copper ion transport cellular copper ion homeostasis response to oxidative stress copper chaperone activity metal ion transport copper-dependent protein binding negative regulation of apoptotic process metal ion binding ATPase binding copper ion export uc007izj.1 uc007izj.2 uc007izj.3 
ENSMUST00000108872.9 Slc36a1 ENSMUST00000108872.9 solute carrier family 36 (proton/amino acid symporter), member 1 (from RefSeq NM_153139.4) ENSMUST00000108872.1 ENSMUST00000108872.2 ENSMUST00000108872.3 ENSMUST00000108872.4 ENSMUST00000108872.5 ENSMUST00000108872.6 ENSMUST00000108872.7 ENSMUST00000108872.8 NM_153139 Pat1 Q811N9 Q8K4D3 S36A1_MOUSE Slc36a1 uc007izd.1 uc007izd.2 uc007izd.3 Electrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers and selected amino acid derivatives such as 4-aminobutanoate/GABA (PubMed:11959859). May be involved in the efflux from the lysosomal compartment of neutral amino acids resulting from proteolysis (By similarity). May play a role in specifying sites for exocytosis in neurons (By similarity). Reaction=glycine(in) + H(+)(in) = glycine(out) + H(+)(out); Xref=Rhea:RHEA:28899, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305; Evidence=; Reaction=H(+)(in) + L-alanine(in) = H(+)(out) + L-alanine(out); Xref=Rhea:RHEA:29443, ChEBI:CHEBI:15378, ChEBI:CHEBI:57972; Evidence=; Reaction=D-alanine(in) + H(+)(in) = D-alanine(out) + H(+)(out); Xref=Rhea:RHEA:28903, ChEBI:CHEBI:15378, ChEBI:CHEBI:57416; Evidence=; Reaction=H(+)(out) + L-proline(out) = H(+)(in) + L-proline(in); Xref=Rhea:RHEA:28963, ChEBI:CHEBI:15378, ChEBI:CHEBI:60039; Evidence=; Reaction=D-proline(out) + H(+)(out) = D-proline(in) + H(+)(in); Xref=Rhea:RHEA:70643, ChEBI:CHEBI:15378, ChEBI:CHEBI:57726; Evidence=; Reaction=H(+)(in) + L-serine(in) = H(+)(out) + L-serine(out); Xref=Rhea:RHEA:28887, ChEBI:CHEBI:15378, ChEBI:CHEBI:33384; Evidence=; Reaction=D-serine(out) + H(+)(out) = D-serine(in) + H(+)(in); Xref=Rhea:RHEA:70647, ChEBI:CHEBI:15378, ChEBI:CHEBI:35247; Evidence=; Reaction=4-aminobutanoate(in) + H(+)(in) = 4-aminobutanoate(out) + H(+)(out); Xref=Rhea:RHEA:28915, ChEBI:CHEBI:15378, ChEBI:CHEBI:59888; Evidence=; Reaction=beta-alanine(in) + H(+)(in) = beta-alanine(out) + H(+)(out); Xref=Rhea:RHEA:29459, ChEBI:CHEBI:15378, ChEBI:CHEBI:57966; Evidence=; Kinetic parameters: KM=7.0 mM for glycine ; KM=7.5 mM for L-alanine ; KM=2.8 mM for L-proline ; KM=69 mM for L-serine ; KM=6.3 mM for D-alanine ; KM=3.1 mM for 4-aminobutanoate/GABA ; Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Note=In neurons, colocalizes with the exocyst complex in the axonal processes. Highly expressed in small intestine, colon, kidney and brain. Belongs to the amino acid/polyamine transporter 2 family. amino acid transmembrane transport hydrogen:amino acid symporter activity lysosome lysosomal membrane endoplasmic reticulum plasma membrane amino acid transport hydrogen ion transmembrane transporter activity amino acid transmembrane transporter activity neutral amino acid transmembrane transporter activity L-alanine transmembrane transporter activity glycine transmembrane transporter activity L-proline transmembrane transporter activity symporter activity neutral amino acid transport L-alanine transport glycine transport proline transport tyrosine transport membrane integral component of membrane proline transmembrane transport hydrogen ion transmembrane transport L-tyrosine transmembrane transporter activity uc007izd.1 uc007izd.2 uc007izd.3 
ENSMUST00000108875.2 Birc7 ENSMUST00000108875.2 baculoviral IAP repeat-containing 7 (from RefSeq NM_001163247.1) A0AUK9 A2AWP0 BIRC7_MOUSE ENSMUST00000108875.1 Livin NM_001163247 uc008oke.1 uc008oke.2 uc008oke.3 Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and MAP3K7/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Binds to caspase-9. Interaction with DIABLO/SMAC via the BIR domain disrupts binding to caspase-9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with caspase-3 and caspase-7 via its BIR domain. Nucleus Cytoplasm Golgi apparatus Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis. The RING domain is essential for autoubiquitination. Autoubiquitinated and undergoes proteasome-mediated degradation. The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect. Belongs to the IAP family. Sequence=AAI07261.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI25014.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ubiquitin-protein transferase activity cysteine-type endopeptidase inhibitor activity nucleus cytoplasm Golgi apparatus microtubule organizing center cytosol apoptotic process negative regulation of peptidase activity protein ubiquitination transferase activity peptidase inhibitor activity positive regulation of protein ubiquitination regulation of cell proliferation cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process metal ion binding ubiquitin protein ligase activity regulation of natural killer cell apoptotic process inhibition of cysteine-type endopeptidase activity involved in apoptotic process uc008oke.1 uc008oke.2 uc008oke.3 
ENSMUST00000108878.2 Bhlhe23 ENSMUST00000108878.2 basic helix-loop-helix family, member e23 (from RefSeq NM_080641.5) BHE23_MOUSE Bhlhb4 ENSMUST00000108878.1 H20 NM_080641 Q71MB7 Q8BGW3 uc008okb.1 uc008okb.2 uc008okb.3 May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation. Nucleus Expressed in brain and retina. Expression is confined to regions of the developing nervous system and pancreas. At 13 dpc expressed at lower levels in the trigeminal ganglion, the ganglionic eminence, the ventral neural tube, and dorsal root ganglia. Expressed at moderate levels in the tectum of the embryonic midbrain. Most prominent expression is in the diencephalon, where it flanks either side of the roof of the third ventricle, dorsal/caudal to the dorsal thalamus. Detected in the pancreas during the time when most of the pancreatic endocrine cell types are beginning to differentiate and endocrine precursor cells remain loosely associated with the duct epithelium until they begin to form aggregates late in development. Disrupted rod signaling and profound retinal dysfunction. DNA binding cellular_component nucleus regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinal rod cell development negative regulation of retinal cell programmed cell death protein dimerization activity post-embryonic eye morphogenesis cell development uc008okb.1 uc008okb.2 uc008okb.3 
ENSMUST00000108891.2 Cables2 ENSMUST00000108891.2 CDK5 and Abl enzyme substrate 2, transcript variant 17 (from RefSeq NR_177235.1) A2ABW9 CABL2_MOUSE ENSMUST00000108891.1 NR_177235 Q8K3M5 uc008oit.1 uc008oit.2 uc008oit.3 Unknown. Probably involved in G1-S cell cycle transition. Binds to CDK3, CDK5 and ABL1. The C-terminal cyclin-box-like region binds to CDK5. Widely expressed. Belongs to the cyclin family. Sequence=AAL12171.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cellular_component cell cycle biological_process cell division regulation of cell cycle uc008oit.1 uc008oit.2 uc008oit.3 
ENSMUST00000108901.8 Mtg2 ENSMUST00000108901.8 mitochondrial ribosome associated GTPase 2, transcript variant 1 (from RefSeq NM_181424.3) A2AFK4 A2AFK4_MOUSE ENSMUST00000108901.1 ENSMUST00000108901.2 ENSMUST00000108901.3 ENSMUST00000108901.4 ENSMUST00000108901.5 ENSMUST00000108901.6 ENSMUST00000108901.7 Gtpbp5 Mtg2 NM_181424 uc290die.1 uc290die.2 Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. magnesium ion binding GTPase activity GTP binding mitochondrion mitochondrial inner membrane mitochondrial matrix mitochondrial ribosome regulation of respiratory system process regulation of mitochondrial translation uc290die.1 uc290die.2 
ENSMUST00000108920.10 Irf1 ENSMUST00000108920.10 interferon regulatory factor 1, transcript variant 1 (from RefSeq NM_008390.2) ENSMUST00000108920.1 ENSMUST00000108920.2 ENSMUST00000108920.3 ENSMUST00000108920.4 ENSMUST00000108920.5 ENSMUST00000108920.6 ENSMUST00000108920.7 ENSMUST00000108920.8 ENSMUST00000108920.9 Irf1 NM_008390 Q5SX13 Q5SX13_MOUSE uc007iww.1 uc007iww.2 uc007iww.3 uc007iww.4 Cytoplasm Nucleus Belongs to the IRF family. nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated apoptotic process cell cycle arrest negative regulation of cell proliferation positive regulation of interferon-beta production cellular response to interferon-beta transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of immune response defense response to virus cellular response to mechanical stimulus uc007iww.1 uc007iww.2 uc007iww.3 uc007iww.4 
ENSMUST00000108924.9 Zfp931 ENSMUST00000108924.9 zinc finger protein 931 (from RefSeq NM_001162922.1) A2AHM2 A2AHM2_MOUSE ENSMUST00000108924.1 ENSMUST00000108924.2 ENSMUST00000108924.3 ENSMUST00000108924.4 ENSMUST00000108924.5 ENSMUST00000108924.6 ENSMUST00000108924.7 ENSMUST00000108924.8 NM_001162922 Zfp931 uc012clr.1 uc012clr.2 uc012clr.3 Nucleus nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc012clr.1 uc012clr.2 uc012clr.3 
ENSMUST00000108926.3 Zfp971 ENSMUST00000108926.3 zinc finger protein 971, transcript variant 1 (from RefSeq NM_001177399.1) A2BFG8 A2BFG8_MOUSE ENSMUST00000108926.1 ENSMUST00000108926.2 NM_001177399 Zfp971 uc012clq.1 uc012clq.2 uc012clq.3 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc012clq.1 uc012clq.2 uc012clq.3 
ENSMUST00000108930.9 Gm14326 ENSMUST00000108930.9 predicted gene 14326, transcript variant 1 (from RefSeq NM_001190302.2) A2BFG5 A2BFG5_MOUSE ENSMUST00000108930.1 ENSMUST00000108930.2 ENSMUST00000108930.3 ENSMUST00000108930.4 ENSMUST00000108930.5 ENSMUST00000108930.6 ENSMUST00000108930.7 ENSMUST00000108930.8 Gm14326 NM_001190302 uc012clp.1 uc012clp.2 uc012clp.3 uc012clp.4 transcription regulatory region sequence-specific DNA binding molecular_function nucleic acid binding cellular_component nucleus regulation of transcription, DNA-templated biological_process metal ion binding uc012clp.1 uc012clp.2 uc012clp.3 uc012clp.4 
ENSMUST00000108934.10 Zfp972 ENSMUST00000108934.10 zinc finger protein 972 (from RefSeq NM_183135.1) A2AW64 A2AW64_MOUSE C330013J21Rik ENSMUST00000108934.1 ENSMUST00000108934.2 ENSMUST00000108934.3 ENSMUST00000108934.4 ENSMUST00000108934.5 ENSMUST00000108934.6 ENSMUST00000108934.7 ENSMUST00000108934.8 ENSMUST00000108934.9 NM_183135 Zfp972 uc008ohf.1 uc008ohf.2 uc008ohf.3 uc008ohf.4 uc008ohf.5 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process uc008ohf.1 uc008ohf.2 uc008ohf.3 uc008ohf.4 uc008ohf.5 
ENSMUST00000108939.9 Gm14325 ENSMUST00000108939.9 predicted gene 14325 (from RefSeq NM_001024849.3) A2AW67 A2AW67_MOUSE ENSMUST00000108939.1 ENSMUST00000108939.2 ENSMUST00000108939.3 ENSMUST00000108939.4 ENSMUST00000108939.5 ENSMUST00000108939.6 ENSMUST00000108939.7 ENSMUST00000108939.8 Gm14325 NM_001024849 uc009vci.1 uc009vci.2 uc009vci.3 uc009vci.4 uc009vci.5 uc009vci.6 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc009vci.1 uc009vci.2 uc009vci.3 uc009vci.4 uc009vci.5 uc009vci.6 
ENSMUST00000108945.9 Gm14406 ENSMUST00000108945.9 Gm14406 (from geneSymbol) A2BFU6 A2BFU6_MOUSE ENSMUST00000108945.1 ENSMUST00000108945.2 ENSMUST00000108945.3 ENSMUST00000108945.4 ENSMUST00000108945.5 ENSMUST00000108945.6 ENSMUST00000108945.7 ENSMUST00000108945.8 Gm14406 uc290dgh.1 uc290dgh.2 uc290dgh.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc290dgh.1 uc290dgh.2 uc290dgh.3 
ENSMUST00000108947.3 Gm14403 ENSMUST00000108947.3 Gm14403 (from geneSymbol) A2BFU4 A2BFU4_MOUSE BC098094 ENSMUST00000108947.1 ENSMUST00000108947.2 Gm14403 uc290dge.1 uc290dge.2 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290dge.1 uc290dge.2 
ENSMUST00000108949.3 Zfp966 ENSMUST00000108949.3 zinc finger protein 966, transcript variant 1 (from RefSeq NM_001177407.1) A2ART2 A2ART2_MOUSE ENSMUST00000108949.1 ENSMUST00000108949.2 NM_001177407 Zfp966 Zfp967 Zfp968 Zfp969 uc012clj.1 uc012clj.2 uc012clj.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc012clj.1 uc012clj.2 uc012clj.3 
ENSMUST00000108951.8 6430548M08Rik ENSMUST00000108951.8 RIKEN cDNA 6430548M08 gene, transcript variant 3 (from RefSeq NM_001163761.1) 6430548M08Rik ENSMUST00000108951.1 ENSMUST00000108951.2 ENSMUST00000108951.3 ENSMUST00000108951.4 ENSMUST00000108951.5 ENSMUST00000108951.6 ENSMUST00000108951.7 NM_001163761 Q3TA40 Q3TA40_MOUSE uc009nqv.1 uc009nqv.2 uc009nqv.3 uc009nqv.4 uc009nqv.1 uc009nqv.2 uc009nqv.3 uc009nqv.4 
ENSMUST00000108952.4 Zfp970 ENSMUST00000108952.4 zinc finger protein 970 (from RefSeq NM_001177568.1) ENSMUST00000108952.1 ENSMUST00000108952.2 ENSMUST00000108952.3 F7CWF0 Gm14420 NM_001177568 OTTMUSG00000016588 Q08BU3 Q08BU3_MOUSE Zfp970 uc008oha.1 uc008oha.2 uc008oha.3 uc008oha.4 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc008oha.1 uc008oha.2 uc008oha.3 uc008oha.4 
ENSMUST00000108959.3 Gm14412 ENSMUST00000108959.3 Gm14412 (from geneSymbol) A2ARR7 A2ARR7_MOUSE ENSMUST00000108959.1 ENSMUST00000108959.2 Gm14412 uc290dfw.1 uc290dfw.2 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc290dfw.1 uc290dfw.2 
ENSMUST00000108961.4 Gm11009 ENSMUST00000108961.4 Belongs to the krueppel C2H2-type zinc-finger protein family. (from UniProt F7CWA7) ENSMUST00000108961.1 ENSMUST00000108961.2 ENSMUST00000108961.3 F7CWA7 F7CWA7_MOUSE Gm11009 uc290dea.1 uc290dea.2 Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc290dea.1 uc290dea.2 
ENSMUST00000108963.3 Zfp1010 ENSMUST00000108963.3 zinc finger protein 1010 (from RefSeq NM_001416218.1) A2ARR8 A2ARR8_MOUSE ENSMUST00000108963.1 ENSMUST00000108963.2 Gm14409 NM_001416218 Zfp1010 uc290dfv.1 uc290dfv.2 uc290dfv.3 nucleic acid binding cellular_component uc290dfv.1 uc290dfv.2 uc290dfv.3 
ENSMUST00000108970.9 Gm14401 ENSMUST00000108970.9 Nucleus (from UniProt A2ARV7) A2ARV7 A2ARV7_MOUSE ENSMUST00000108970.1 ENSMUST00000108970.2 ENSMUST00000108970.3 ENSMUST00000108970.4 ENSMUST00000108970.5 ENSMUST00000108970.6 ENSMUST00000108970.7 ENSMUST00000108970.8 Gm14401 uc290dfi.1 uc290dfi.2 Nucleus nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290dfi.1 uc290dfi.2 
ENSMUST00000108981.9 Gm14305 ENSMUST00000108981.9 predicted gene 14305 (from RefSeq NM_001099327.1) A2BE23 A2BE23_MOUSE ENSMUST00000108981.1 ENSMUST00000108981.2 ENSMUST00000108981.3 ENSMUST00000108981.4 ENSMUST00000108981.5 ENSMUST00000108981.6 ENSMUST00000108981.7 ENSMUST00000108981.8 Gm14305 NM_001099327 RP23-376N23.2-001 RP24-574J13.4-001 uc008ogs.1 uc008ogs.2 uc008ogs.3 uc008ogs.4 uc008ogs.5 Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008ogs.1 uc008ogs.2 uc008ogs.3 uc008ogs.4 uc008ogs.5 
ENSMUST00000108985.9 Zfp973 ENSMUST00000108985.9 zinc finger protein 973 (from RefSeq NM_001242943.2) A2BE20 A2BE20_MOUSE ENSMUST00000108985.1 ENSMUST00000108985.2 ENSMUST00000108985.3 ENSMUST00000108985.4 ENSMUST00000108985.5 ENSMUST00000108985.6 ENSMUST00000108985.7 ENSMUST00000108985.8 NM_001242943 RP23-376N23.3-001 RP24-574J13.3-003 Zfp965 Zfp973 uc057lfi.1 uc057lfi.2 uc057lfi.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc057lfi.1 uc057lfi.2 uc057lfi.3 
ENSMUST00000108990.9 Gm14308 ENSMUST00000108990.9 predicted gene 14308 (from RefSeq NM_001099349.2) A2ART4 A2ART4_MOUSE ENSMUST00000108990.1 ENSMUST00000108990.2 ENSMUST00000108990.3 ENSMUST00000108990.4 ENSMUST00000108990.5 ENSMUST00000108990.6 ENSMUST00000108990.7 ENSMUST00000108990.8 Gm11007 Gm14308 Gm14434 Gm2007 Gm2026 Gm4631 Gm4724 NM_001099349 RP23-376N23.4-001 RP24-574J13.1-003 uc008ogq.1 uc008ogq.2 uc008ogq.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc008ogq.1 uc008ogq.2 uc008ogq.3 
ENSMUST00000109002.9 Zfp965 ENSMUST00000109002.9 zinc finger protein 965 (from RefSeq NM_001242944.1) A2BE20 A2BE20_MOUSE ENSMUST00000109002.1 ENSMUST00000109002.2 ENSMUST00000109002.3 ENSMUST00000109002.4 ENSMUST00000109002.5 ENSMUST00000109002.6 ENSMUST00000109002.7 ENSMUST00000109002.8 NM_001242944 RP23-376N23.3-001 RP24-574J13.3-003 Zfp965 Zfp973 uc029uin.1 uc029uin.2 uc029uin.3 uc029uin.4 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc029uin.1 uc029uin.2 uc029uin.3 uc029uin.4 
ENSMUST00000109008.4 Gm2026 ENSMUST00000109008.4 predicted gene 2026 (from RefSeq NM_001177543.1) A2ART4 A2ART4_MOUSE ENSMUST00000109008.1 ENSMUST00000109008.2 ENSMUST00000109008.3 Gm11007 Gm14308 Gm14434 Gm2007 Gm2026 Gm4631 Gm4724 NM_001177543 RP23-376N23.4-001 RP24-574J13.1-003 uc290ddo.1 uc290ddo.2 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290ddo.1 uc290ddo.2 
ENSMUST00000109012.4 Gm6710 ENSMUST00000109012.4 predicted gene 6710 (from RefSeq NM_001164689.1) A2ART0 A2ART0_MOUSE ENSMUST00000109012.1 ENSMUST00000109012.2 ENSMUST00000109012.3 F7CJX1 Gm14391 Gm6710 NM_001164689 uc290ddk.1 uc290ddk.2 nucleic acid binding transcription factor activity, sequence-specific DNA binding cellular_component nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc290ddk.1 uc290ddk.2 
ENSMUST00000109013.9 Shroom1 ENSMUST00000109013.9 shroom family member 1, transcript variant 1 (from RefSeq NM_027917.3) B1AQY5 B1AQY6 ENSMUST00000109013.1 ENSMUST00000109013.2 ENSMUST00000109013.3 ENSMUST00000109013.4 ENSMUST00000109013.5 ENSMUST00000109013.6 ENSMUST00000109013.7 ENSMUST00000109013.8 NM_027917 Q5SX79 Q5SX83 Q99JP8 SHRM1_MOUSE uc007iwc.1 uc007iwc.2 uc007iwc.3 May be involved in the assembly of microtubule arrays during cell elongation. Interacts with F-actin. Cytoplasm, cytoskeleton Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SX79-1; Sequence=Displayed; Name=2; IsoId=Q5SX79-2; Sequence=VSP_024963; The ASD1 domain mediates F-actin binding. Belongs to the shroom family. cell morphogenesis actin binding cytoplasm cytoskeleton microtubule adherens junction actin filament organization apical plasma membrane actin cytoskeleton organization cortical actin cytoskeleton apical junction complex myosin II binding actin filament binding actin filament bundle assembly uc007iwc.1 uc007iwc.2 uc007iwc.3 
ENSMUST00000109032.4 Gm11008 ENSMUST00000109032.4 Gm11008 (from geneSymbol) ENSMUST00000109032.1 ENSMUST00000109032.2 ENSMUST00000109032.3 uc290ddq.1 uc290ddq.2 uc290ddq.1 uc290ddq.2 
ENSMUST00000109045.9 Gm4724 ENSMUST00000109045.9 predicted gene 4724 (from RefSeq NM_001256480.1) A2ART4 A2ART4_MOUSE ENSMUST00000109045.1 ENSMUST00000109045.2 ENSMUST00000109045.3 ENSMUST00000109045.4 ENSMUST00000109045.5 ENSMUST00000109045.6 ENSMUST00000109045.7 ENSMUST00000109045.8 Gm11007 Gm14308 Gm14434 Gm2007 Gm2026 Gm4631 Gm4724 NM_001256480 RP23-376N23.4-001 RP24-574J13.1-003 uc008ogo.1 uc008ogo.2 uc008ogo.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc008ogo.1 uc008ogo.2 uc008ogo.3 
ENSMUST00000109047.4 Zfp968 ENSMUST00000109047.4 zinc finger protein 968 (from RefSeq NM_001374746.1) A2ART2 A2ART2_MOUSE ENSMUST00000109047.1 ENSMUST00000109047.2 ENSMUST00000109047.3 NM_001374746 Zfp966 Zfp967 Zfp968 Zfp969 uc290dcl.1 uc290dcl.2 uc290dcl.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290dcl.1 uc290dcl.2 uc290dcl.3 
ENSMUST00000109049.11 Gm2004 ENSMUST00000109049.11 predicted gene 2004, transcript variant 5 (from RefSeq NM_001408192.1) A2ARL5 A2ARL5_MOUSE ENSMUST00000109049.1 ENSMUST00000109049.10 ENSMUST00000109049.2 ENSMUST00000109049.3 ENSMUST00000109049.4 ENSMUST00000109049.5 ENSMUST00000109049.6 ENSMUST00000109049.7 ENSMUST00000109049.8 ENSMUST00000109049.9 Gm14419 Gm2004 NM_001408192 uc290dds.1 uc290dds.2 uc290dds.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc290dds.1 uc290dds.2 uc290dds.3 
ENSMUST00000109054.3 Gm14443 ENSMUST00000109054.3 Gm14443 (from geneSymbol) A2ARX0 A2ARX0_MOUSE BC071190 ENSMUST00000109054.1 ENSMUST00000109054.2 Gm14443 uc290dbx.1 uc290dbx.2 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290dbx.1 uc290dbx.2 
ENSMUST00000109057.8 9530068E07Rik ENSMUST00000109057.8 9530068E07Rik (from geneSymbol) 9530068E07Rik A0A0A0MQD4 A0A0A0MQD4_MOUSE AK079269 ENSMUST00000109057.1 ENSMUST00000109057.2 ENSMUST00000109057.3 ENSMUST00000109057.4 ENSMUST00000109057.5 ENSMUST00000109057.6 ENSMUST00000109057.7 uc287ybi.1 uc287ybi.2 membrane integral component of membrane uc287ybi.1 uc287ybi.2 
ENSMUST00000109058.9 Gm14391 ENSMUST00000109058.9 predicted gene 14391, transcript variant 1 (from RefSeq NM_001099308.2) A2ART0 A2ART0_MOUSE ENSMUST00000109058.1 ENSMUST00000109058.2 ENSMUST00000109058.3 ENSMUST00000109058.4 ENSMUST00000109058.5 ENSMUST00000109058.6 ENSMUST00000109058.7 ENSMUST00000109058.8 F7CJX1 Gm14391 Gm6710 NM_001099308 uc008ofn.1 uc008ofn.2 uc008ofn.3 uc008ofn.4 uc008ofn.5 nucleic acid binding transcription factor activity, sequence-specific DNA binding cellular_component nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc008ofn.1 uc008ofn.2 uc008ofn.3 uc008ofn.4 uc008ofn.5 
ENSMUST00000109060.8 Gm14399 ENSMUST00000109060.8 predicted gene 14399 (from RefSeq NM_001388486.1) A2ARW8 A2ARW8_MOUSE ENSMUST00000109060.1 ENSMUST00000109060.2 ENSMUST00000109060.3 ENSMUST00000109060.4 ENSMUST00000109060.5 ENSMUST00000109060.6 ENSMUST00000109060.7 Gm14399 NM_001388486 uc290dbt.1 uc290dbt.2 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290dbt.1 uc290dbt.2 
ENSMUST00000109070.4 Gm14444 ENSMUST00000109070.4 predicted gene 14444 (from RefSeq NM_001378705.1) A2ARW3 A2ARW3_MOUSE ENSMUST00000109070.1 ENSMUST00000109070.2 ENSMUST00000109070.3 Gm14444 NM_001378705 uc290dbk.1 uc290dbk.2 uc290dbk.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290dbk.1 uc290dbk.2 uc290dbk.3 
ENSMUST00000109071.3 Tcf7 ENSMUST00000109071.3 transcription factor 7, T cell specific, transcript variant 6 (from RefSeq NM_001427425.1) A0A5K1VVQ7 A0A5K1VVQ7_MOUSE ENSMUST00000109071.1 ENSMUST00000109071.2 NM_001427425 Tcf7 uc007ivk.1 uc007ivk.2 uc007ivk.3 uc007ivk.4 uc007ivk.5 Nucleus Belongs to the TCF/LEF family. uc007ivk.1 uc007ivk.2 uc007ivk.3 uc007ivk.4 uc007ivk.5 
ENSMUST00000109075.8 Nelfcd ENSMUST00000109075.8 negative elongation factor complex member C/D, Th1l (from RefSeq NM_020580.4) A2AQ05 ENSMUST00000109075.1 ENSMUST00000109075.2 ENSMUST00000109075.3 ENSMUST00000109075.4 ENSMUST00000109075.5 ENSMUST00000109075.6 ENSMUST00000109075.7 NELFD_MOUSE NM_020580 Nelfd Q922L6 Q9QXC8 Q9QXC9 Q9QXD0 Th1 Th1l uc008ofc.1 uc008ofc.2 Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). The NELF complex is composed of NELFA, NELFB, NELFCD and NELFE; NELFA and NELFCD form a stable subcomplex that binds primarily through NELFCD to the N-terminus of NELFB (By similarity). Binds RNA which may help to stabilize the NELF complex on nucleic acid (By similarity). In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure-dependent manner (By similarity). Interacts with ARAF1 (By similarity). Interacts with PCF11 (By similarity). Interacts with NELFB (PubMed:26010750). Interacts with KAT8 (PubMed:17335777). Nucleus Belongs to the NELF-D family. Sequence=AAH31747.1; Type=Erroneous initiation; Evidence=; Sequence=BAB26880.1; Type=Erroneous initiation; Evidence=; Sequence=BAC33744.1; Type=Erroneous initiation; Evidence=; Sequence=CAB65252.1; Type=Erroneous initiation; Evidence=; Sequence=CAB65253.1; Type=Erroneous initiation; Evidence=; Sequence=CAB65254.1; Type=Erroneous initiation; Evidence=; RNA binding protein binding nucleus NELF complex negative regulation of transcription elongation from RNA polymerase II promoter negative regulation of transcription, DNA-templated uc008ofc.1 uc008ofc.2 
ENSMUST00000109085.8 Gnas ENSMUST00000109085.8 GNAS complex locus, transcript variant 8 (from RefSeq NM_001077510.5) A2A611 A2A612 A2A613 ENSMUST00000109085.1 ENSMUST00000109085.2 ENSMUST00000109085.3 ENSMUST00000109085.4 ENSMUST00000109085.5 ENSMUST00000109085.6 ENSMUST00000109085.7 GNAS2_MOUSE Gnas1 MNCb-5546 NM_001077510 P04894 P08755 P63094 Q3KQM5 Q3TFV3 Q3TWS9 Q3UI70 Q58E62 Q6P7U9 Q80ZK6 Q8K5E1 Q9Z1R7 uc033hrs.1 uc033hrs.2 uc033hrs.3 uc033hrs.4 This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2015]. Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts with CRY1; the interaction may block GPCR- mediated regulation of cAMP concentrations. Interacts with ADCY6 and stimulates its adenylyl cyclase activity (By similarity). Interacts with ADCY2 and ADCY5 (By similarity). Stimulates the ADCY5 adenylyl cyclase activity (By similarity). Interaction with SASH1 (By similarity). Interacts with GASL2L2 (PubMed:23994616). Cell membrane ; Lipid-anchor Event=Alternative splicing; Named isoforms=9; Name=Gnas-1; IsoId=P63094-1; Sequence=Displayed; Name=Gnas-2; IsoId=P63094-2; Sequence=VSP_011567; Name=Gnas-3; Synonyms=NTas; IsoId=P63094-3; Sequence=VSP_021153; Name=XLas-1; Synonyms=XXL; IsoId=Q6R0H7-1; Sequence=External; Name=XLas-2; Synonyms=XXLb1; IsoId=Q6R0H7-2; Sequence=External; Name=XLas-3; Synonyms=XXLb2; IsoId=Q6R0H7-3; Sequence=External; Name=XLas-4; IsoId=Q6R0H7-4; Sequence=External; Name=Nesp55-1; IsoId=Q9Z0F1-1; Sequence=External; Name=Nesp55-2; IsoId=Q9Z0F1-2; Sequence=External; This protein is produced by a bicistronic gene which also produces the ALEX protein from an overlapping reading frame. The GNAS locus is imprinted in a complex manner, giving rise to distinct paternally, maternally and biallelically expressed proteins. The XLas isoforms are paternally derived, the Gnas isoforms are biallelically derived and the Nesp55 isoforms are maternally derived. Belongs to the G-alpha family. G(s) subfamily. It was found (PubMed:8227063) that in engineered, C3S- mutagenized sequence expressed in HEK293 cells there was no radiolabeling by either S- or N-palmitoylation. This result is incompatible with a prediction for N-palmitoylation unless N- palmitoylation depends on S-palmitoylation occurring first or N- palmitoylation did not occur in the experimental expression system. Sequence=BAB93551.1; Type=Miscellaneous discrepancy; Evidence=; Sequence=CAM24410.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding skeletal system development G-protein coupled receptor binding ruffle tissue homeostasis positive regulation of protein phosphorylation endochondral ossification G-protein alpha-subunit binding GTPase activity insulin-like growth factor receptor binding protein binding GTP binding nucleus cytoplasm endosome cytosol heterotrimeric G-protein complex plasma membrane energy reserve metabolic process DNA methylation regulation of transcription from RNA polymerase II promoter signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway positive regulation of cell proliferation post-embryonic development regulation of signal transduction positive regulation of sodium ion transport adenylate cyclase activator activity membrane guanyl nucleotide binding protein domain specific binding Golgi to ER transport vesicle dendrite intrinsic component of membrane G-protein beta-subunit binding G-protein beta/gamma-subunit complex binding beta-2 adrenergic receptor binding D1 dopamine receptor binding mu-type opioid receptor binding trans-Golgi network membrane embryonic hindlimb morphogenesis ionotropic glutamate receptor binding multicellular organism growth negative regulation of renal sodium excretion post-embryonic body morphogenesis response to drug alpha-tubulin binding neuronal cell body positive regulation of GTPase activity skin development positive regulation of cAMP-mediated signaling membrane raft positive regulation of osteoblast differentiation positive regulation of osteoclast differentiation negative regulation of blood pressure metal ion binding alkylglycerophosphoethanolamine phosphodiesterase activity perinuclear region of cytoplasm developmental growth embryonic cranial skeleton morphogenesis cognition cartilage development corticotropin-releasing hormone receptor 1 binding recycling endosome calcium ion homeostasis bone development hair follicle placode formation platelet aggregation response to parathyroid hormone cellular response to prostaglandin E stimulus genetic imprinting cellular response to catecholamine stimulus adenylate cyclase-activating adrenergic receptor signaling pathway regulation of parathyroid hormone secretion Golgi apparatus sarcolemma uc033hrs.1 uc033hrs.2 uc033hrs.3 uc033hrs.4 
ENSMUST00000109093.10 Pkd1l2 ENSMUST00000109093.10 polycystic kidney disease 1 like 2 (from RefSeq NM_029686.4) E9QPG2 E9QPG2_MOUSE ENSMUST00000109093.1 ENSMUST00000109093.2 ENSMUST00000109093.3 ENSMUST00000109093.4 ENSMUST00000109093.5 ENSMUST00000109093.6 ENSMUST00000109093.7 ENSMUST00000109093.8 ENSMUST00000109093.9 NM_029686 Pkd1l2 uc292djp.1 uc292djp.2 uc292djp.3 Membrane ; Multi- pass membrane protein Belongs to the polycystin family. Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding membrane integral component of membrane carbohydrate binding uc292djp.1 uc292djp.2 uc292djp.3 
ENSMUST00000109097.9 Sec24a ENSMUST00000109097.9 SEC24 homolog A, COPII coat complex component, transcript variant 1 (from RefSeq NM_175255.3) A2AA70 A2AA73 A4FUV4 ENSMUST00000109097.1 ENSMUST00000109097.2 ENSMUST00000109097.3 ENSMUST00000109097.4 ENSMUST00000109097.5 ENSMUST00000109097.6 ENSMUST00000109097.7 ENSMUST00000109097.8 NM_175255 Q3TQ05 Q3TRG7 Q3U2P1 Q8BIS0 SC24A_MOUSE Sec24a uc007iui.1 uc007iui.2 uc007iui.3 Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with TMED2. Interacts (as part of the Sec23/24 complex) with SEC22B; recruits SEC22B into COPII-coated vesicles for its transport from the endoplasmic reticulum to the Golgi (By similarity). Interacts with STING1; promoting STING1 translocation to COPII vesicles in a STEEP1-dependent manner (By similarity). Interacts with TMEM39A (By similarity). Interacts with SACM1L; this interaction is reduced in the absence of TMEM39A (By similarity). Interacts with kinase FAM20C; transport of FAM20C from the endoplasmic reticulum to the Golgi is likely to be mediated by COPII vesicles (By similarity). Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U2P1-1; Sequence=Displayed; Name=2; IsoId=Q3U2P1-2; Sequence=VSP_016990, VSP_016991; Belongs to the SEC23/SEC24 family. SEC24 subfamily. Sequence=BAC26319.1; Type=Frameshift; Evidence=; Golgi membrane cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol intracellular protein transport ER to Golgi vesicle-mediated transport zinc ion binding ER to Golgi transport vesicle membrane protein transport membrane vesicle-mediated transport COPII vesicle coat cytoplasmic vesicle cholesterol homeostasis regulation of low-density lipoprotein particle receptor biosynthetic process metal ion binding positive regulation of protein secretion cargo loading into COPII-coated vesicle uc007iui.1 uc007iui.2 uc007iui.3 
ENSMUST00000109098.2 Trappc2b ENSMUST00000109098.2 trafficking protein particle complex 2B, transcript variant 4 (from RefSeq NM_001417822.1) 0610009B22Rik ENSMUST00000109098.1 NM_001417822 Q8R3W2 Q8R3W2_MOUSE Trappc2b uc033fvl.1 uc033fvl.2 uc033fvl.3 Cytoplasm, perinuclear region Belongs to the TRAPP small subunits family. Sedlin subfamily. molecular_function cellular_component cytoplasm ER to Golgi vesicle-mediated transport biological_process uc033fvl.1 uc033fvl.2 uc033fvl.3 
ENSMUST00000109099.4 Atmin ENSMUST00000109099.4 ATM interactor (from RefSeq NM_177700.4) ATMIN_MOUSE Atmin ENSMUST00000109099.1 ENSMUST00000109099.2 ENSMUST00000109099.3 Kiaa0431 NM_177700 Q05CB1 Q6P9S1 Q80U05 Q8C311 uc009nop.1 uc009nop.2 uc009nop.3 Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM (By similarity). Binds to the DYNLL1 promoter and activates its transcription. Interacts via its C-terminus with ATM. Interacts with DYNLL; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. ATMIN. Nucleus Note=Nuclear, in discrete foci during G1 phase. Sequence=AAH27752.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH60631.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC39849.1; Type=Frameshift; Evidence=; nucleic acid binding nucleus cellular response to DNA damage stimulus positive regulation of gene expression nuclear body transcription regulatory region DNA binding motile cilium assembly positive regulation of transcription, DNA-templated metal ion binding dynein complex binding positive regulation of non-motile cilium assembly uc009nop.1 uc009nop.2 uc009nop.3 
ENSMUST00000109100.2 Fam186b ENSMUST00000109100.2 family with sequence similarity 186, member B (from RefSeq NM_001081254.1) D3Z420 D3Z420_MOUSE ENSMUST00000109100.1 Fam186b NM_001081254 uc007xpf.1 uc007xpf.2 molecular_function biological_process macromolecular complex uc007xpf.1 uc007xpf.2 
ENSMUST00000109102.4 Cdyl2 ENSMUST00000109102.4 chromodomain protein, Y chromosome-like 2 (from RefSeq NM_029441.3) CDYL2_MOUSE ENSMUST00000109102.1 ENSMUST00000109102.2 ENSMUST00000109102.3 NM_029441 Q9D5D8 uc009noi.1 uc009noi.2 uc009noi.3 uc009noi.4 Interacts (via chromo domain) with histone H3K9me3. Nucleus transcription corepressor activity catalytic activity nucleus methylated histone binding negative regulation of nucleic acid-templated transcription uc009noi.1 uc009noi.2 uc009noi.3 uc009noi.4 
ENSMUST00000109103.4 Hnrnpab ENSMUST00000109103.4 heterogeneous nuclear ribonucleoprotein A/B, transcript variant 1 (from RefSeq NM_001048061.1) ENSMUST00000109103.1 ENSMUST00000109103.2 ENSMUST00000109103.3 Hnrnpab Hnrpab NM_001048061 Q20BD0 Q20BD0_MOUSE uc007itz.1 uc007itz.2 uc007itz.3 This gene encodes a protein with consensus RNA binding domains present in a number of other RNA binding proteins and a glycine-rich C-terminus. This gene overlaps in a tail-to-tail orientation the gene encoding alanine-glyoxylate aminotransferase 2-like 2. Some of the exons of this gene are interspersed with exons of alanine-glyoxylate aminotransferase 2-like 2. Two alternatively spliced transcript variants that encode distinct proteins have been described for this gene. [provided by RefSeq, Jul 2008]. Nucleus nucleic acid binding RNA binding nucleoplasm ribonucleoprotein complex uc007itz.1 uc007itz.2 uc007itz.3 
ENSMUST00000109123.2 4933414I15Rik ENSMUST00000109123.2 4933414I15Rik (from geneSymbol) 4933414I15Rik AK016600 ENSMUST00000109123.1 Q9D4D5 Q9D4D5_MOUSE uc287xxx.1 uc287xxx.2 molecular_function cellular_component biological_process uc287xxx.1 uc287xxx.2 
ENSMUST00000109124.10 Zfp354b ENSMUST00000109124.10 zinc finger protein 354B (from RefSeq NM_013744.3) ENSMUST00000109124.1 ENSMUST00000109124.2 ENSMUST00000109124.3 ENSMUST00000109124.4 ENSMUST00000109124.5 ENSMUST00000109124.6 ENSMUST00000109124.7 ENSMUST00000109124.8 ENSMUST00000109124.9 Kid2 NM_013744 Q9CV15 Q9QXT9 Z354B_MOUSE Znf354b uc007itd.1 uc007itd.2 uc007itd.3 uc007itd.4 May be involved in transcriptional regulation. Nucleus Expressed in brain and kidney. Lower levels in lung, muscle, heart, testis, tongue and eye. Expressed at 16.5 dpc in brain, heart, lung, kidney and gut. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter nucleic acid binding DNA binding chromatin binding nucleus regulation of transcription, DNA-templated metal ion binding uc007itd.1 uc007itd.2 uc007itd.3 uc007itd.4 
ENSMUST00000109134.8 Zfp879 ENSMUST00000109134.8 May be involved in transcriptional regulation. (from UniProt Q8BI99) AK036152 ENSMUST00000109134.1 ENSMUST00000109134.2 ENSMUST00000109134.3 ENSMUST00000109134.4 ENSMUST00000109134.5 ENSMUST00000109134.6 ENSMUST00000109134.7 Q8BI99 ZN879_MOUSE Znf879 uc287xxj.1 uc287xxj.2 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc287xxj.1 uc287xxj.2 
ENSMUST00000109135.9 Zfp354c ENSMUST00000109135.9 zinc finger protein 354C (from RefSeq NM_013922.4) ENSMUST00000109135.1 ENSMUST00000109135.2 ENSMUST00000109135.3 ENSMUST00000109135.4 ENSMUST00000109135.5 ENSMUST00000109135.6 ENSMUST00000109135.7 ENSMUST00000109135.8 Kiaa4218 Kid3 NM_013922 Q3UKS9 Q571J5 Q8C365 Q9JLD3 Z354C_MOUSE Znf354c uc007isq.1 uc007isq.2 uc007isq.3 May function as a transcription repressor. Binds to 5'-CCACA- 3' core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912). Nucleus Expressed in brain. Lower levels in kidney, heart, lung, spleen and eye. Down-regulated during kidney maturation. Expressed in embryonic myogenic progenitor cells, not expressed in adult and aged satellite cells (PubMed:27446912). In myogenic progenitor cells, expressed during early myogenic development (11.5 dpc) to be gradually down-regulated during the fetal stages (from 14.5 dpc to adulthood). KRAB domain is not required for nuclear targeting or for DNA binding. Zinc finger region is involved in nuclear targeting and DNA- binding. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAD90379.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleic acid binding DNA binding nucleus cytosol regulation of transcription, DNA-templated nuclear membrane metal ion binding uc007isq.1 uc007isq.2 uc007isq.3 
ENSMUST00000109136.3 Cass4 ENSMUST00000109136.3 Cas scaffolding protein family member 4, transcript variant 7 (from RefSeq NM_001379467.2) A1L397 CASS4_MOUSE Cass4 ENSMUST00000109136.1 ENSMUST00000109136.2 NM_001379467 Q08EC3 Q08EC4 Q3TCH3 uc008ocs.1 uc008ocs.2 uc008ocs.3 uc008ocs.4 Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading (By similarity). Interacts (via SH3 domain) with PTK2/FAK1 (via C-terminus). Cytoplasm, cytoskeleton Cell junction, focal adhesion Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q08EC4-1; Sequence=Displayed; Name=2 ; IsoId=Q08EC4-2; Sequence=VSP_052948, VSP_052950; Name=3 ; IsoId=Q08EC4-3; Sequence=VSP_052949, VSP_052951; Phosphorylated on tyrosines by SRC. Belongs to the CAS family. cytoplasm cytoskeleton focal adhesion cell adhesion cell migration cell junction positive regulation of cell migration positive regulation of protein tyrosine kinase activity actin filament reorganization positive regulation of substrate adhesion-dependent cell spreading protein tyrosine kinase binding plasma membrane uc008ocs.1 uc008ocs.2 uc008ocs.3 uc008ocs.4 
ENSMUST00000109140.10 Aurka ENSMUST00000109140.10 aurora kinase A, transcript variant 8 (from RefSeq NR_185245.1) Aurka ENSMUST00000109140.1 ENSMUST00000109140.2 ENSMUST00000109140.3 ENSMUST00000109140.4 ENSMUST00000109140.5 ENSMUST00000109140.6 ENSMUST00000109140.7 ENSMUST00000109140.8 ENSMUST00000109140.9 NR_185245 Q3TEY6 Q3TEY6_MOUSE uc008oco.1 uc008oco.2 uc008oco.3 uc008oco.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Cell projection, cilium Cell projection, neuron projection Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation kinase activity phosphorylation uc008oco.1 uc008oco.2 uc008oco.3 uc008oco.4 
ENSMUST00000109142.8 Hnrnph1 ENSMUST00000109142.8 heterogeneous nuclear ribonucleoprotein H1, transcript variant 4 (from RefSeq NM_001362523.1) ENSMUST00000109142.1 ENSMUST00000109142.2 ENSMUST00000109142.3 ENSMUST00000109142.4 ENSMUST00000109142.5 ENSMUST00000109142.6 ENSMUST00000109142.7 Hnrnph1 Hnrph1 NM_001362523 Q811L7 Q811L7_MOUSE uc007isj.1 uc007isj.2 uc007isj.3 Nucleus, nucleoplasm nucleic acid binding RNA binding uc007isj.1 uc007isj.2 uc007isj.3 
ENSMUST00000109155.8 Zfp217 ENSMUST00000109155.8 zinc finger protein 217, transcript variant 2 (from RefSeq NM_001159683.1) ENSMUST00000109155.1 ENSMUST00000109155.2 ENSMUST00000109155.3 ENSMUST00000109155.4 ENSMUST00000109155.5 ENSMUST00000109155.6 ENSMUST00000109155.7 NM_001159683 Q3U0X6 Q3U0X6_MOUSE Zfp217 uc008obv.1 uc008obv.2 uc008obv.3 uc008obv.4 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding nucleoplasm mitochondrion regulation of transcription, DNA-templated cell aging nuclear speck transcription regulatory region DNA binding negative regulation of transcription, DNA-templated uc008obv.1 uc008obv.2 uc008obv.3 uc008obv.4 
ENSMUST00000109159.3 Tshz2 ENSMUST00000109159.3 teashirt zinc finger family member 2, transcript variant 4 (from RefSeq NM_177659.2) ENSMUST00000109159.1 ENSMUST00000109159.2 Kiaa4248 NM_177659 Q5DTF1 Q68FE9 Q6AXH5 Q9JL71 Sdccag33l TSH2_MOUSE Tsh2 Zfp218 Znf218 uc008obp.1 uc008obp.2 uc008obp.3 uc008obp.4 Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Interacts (via homeobox domain) with APBB1 (via PID domain 1). Nucleus Expressed in mesenchymal cells in proximal ureters at 14 dpc, preceding the smooth muscle precursor cells differentiation and the expression of contractile proteins from 15 dpc. Sumoylated. Belongs to the teashirt C2H2-type zinc-finger protein family. Sequence=AAF64095.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAD90333.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleic acid binding DNA binding chromatin binding protein binding nucleus regulation of transcription from RNA polymerase II promoter multicellular organism development regulation of gene expression metal ion binding uc008obp.1 uc008obp.2 uc008obp.3 uc008obp.4 
ENSMUST00000109162.9 Zfp64 ENSMUST00000109162.9 zinc finger protein 64, transcript variant 2 (from RefSeq NM_001369059.1) A2AQR3 A2AQR3_MOUSE ENSMUST00000109162.1 ENSMUST00000109162.2 ENSMUST00000109162.3 ENSMUST00000109162.4 ENSMUST00000109162.5 ENSMUST00000109162.6 ENSMUST00000109162.7 ENSMUST00000109162.8 NM_001369059 Zfp64 uc008obj.1 uc008obj.2 uc008obj.3 Nucleus nucleic acid binding uc008obj.1 uc008obj.2 uc008obj.3 
ENSMUST00000109166.8 Aida ENSMUST00000109166.8 axin interactor, dorsalization associated (from RefSeq NM_181732.4) AIDA_MOUSE ENSMUST00000109166.1 ENSMUST00000109166.2 ENSMUST00000109166.3 ENSMUST00000109166.4 ENSMUST00000109166.5 ENSMUST00000109166.6 ENSMUST00000109166.7 NM_181732 Q3U6V0 Q3UP85 Q6NXY2 Q6PG77 Q78W09 Q8C4Q6 Q99K80 uc008icu.1 uc008icu.2 uc008icu.3 uc008icu.4 Acts as a ventralizing factor during embryogenesis (By similarity). Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta- catenin-independent dorsalization pathway activated by AXIN/JNK- signaling. Interacts with AXIN1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C4Q6-1; Sequence=Displayed; Name=2; IsoId=Q8C4Q6-2; Sequence=VSP_028323; Belongs to the AIDA family. protein binding cytoplasm multicellular organism development dorsal/ventral pattern formation membrane protein domain specific binding phosphatidylinositol binding regulation of protein homodimerization activity negative regulation of JUN kinase activity negative regulation of JNK cascade determination of ventral identity negative regulation of determination of dorsal identity negative regulation of Wnt signaling pathway uc008icu.1 uc008icu.2 uc008icu.3 uc008icu.4 
ENSMUST00000109191.2 Kcng1 ENSMUST00000109191.2 potassium voltage-gated channel, subfamily G, member 1, transcript variant 1 (from RefSeq NM_001081134.2) B2RVK9 B2RVK9_MOUSE ENSMUST00000109191.1 Kcng1 NM_001081134 uc290cus.1 uc290cus.2 Membrane ; Multi- pass membrane protein ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane regulation of ion transmembrane transport protein homooligomerization transmembrane transport potassium ion transmembrane transport regulation of delayed rectifier potassium channel activity uc290cus.1 uc290cus.2 
ENSMUST00000109197.8 Zfp62 ENSMUST00000109197.8 zinc finger protein 62, transcript variant 16 (from RefSeq NM_001425613.1) ENSMUST00000109197.1 ENSMUST00000109197.2 ENSMUST00000109197.3 ENSMUST00000109197.4 ENSMUST00000109197.5 ENSMUST00000109197.6 ENSMUST00000109197.7 NM_001425613 Q3U3H0 Q62510 Q8BT00 Q8C2S6 Q8C827 Q8R5D1 ZFP62_MOUSE uc007ipw.1 uc007ipw.2 uc007ipw.3 May play a role in differentiating skeletal muscle. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C827-1; Sequence=Displayed; Name=2; IsoId=Q8C827-2; Sequence=VSP_010137; Name=3; IsoId=Q8C827-3; Sequence=VSP_010138; Expressed in skeletal and cardiac muscle. At 8.5 dpc, expressed predominantly in neural tube and somites. At 9.5 dpc, expression is higher in the peripheral region of the brain, in the dorsal region of the neural tube, in the segmental plate and in the somites. In developing brain, expression is restricted to regions with actively proliferating cells. At later stages, expressed in many tissues of neuroectodermal and mesodermal origin. At 17 dpc, expression is high in the skeletal muscle fibers, which are mitotically arrested and terminally differentiated. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAH22935.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC25897.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; nucleic acid binding DNA binding nucleus metal ion binding uc007ipw.1 uc007ipw.2 uc007ipw.3 
ENSMUST00000109202.3 Ifi47 ENSMUST00000109202.3 interferon gamma inducible protein 47, transcript variant 3 (from RefSeq NM_001271677.1) ENSMUST00000109202.1 ENSMUST00000109202.2 IRG-47 Ifggc1 Ifi47 NM_001271677 Q61635 Q61635_MOUSE uc007ipq.1 uc007ipq.2 uc007ipq.3 uc007ipq.4 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. GTPase activity GTP binding endoplasmic reticulum endoplasmic reticulum membrane defense response membrane cellular response to interferon-beta uc007ipq.1 uc007ipq.2 uc007ipq.3 uc007ipq.4 
ENSMUST00000109207.10 Ube2v1 ENSMUST00000109207.10 ubiquitin-conjugating enzyme E2 variant 1, transcript variant 2 (from RefSeq NM_023230.2) A2A467 Croc1 ENSMUST00000109207.1 ENSMUST00000109207.2 ENSMUST00000109207.3 ENSMUST00000109207.4 ENSMUST00000109207.5 ENSMUST00000109207.6 ENSMUST00000109207.7 ENSMUST00000109207.8 ENSMUST00000109207.9 NM_023230 Q8VEB5 Q9CZY3 Q9ERI7 UB2V1_MOUSE uc008oaa.1 uc008oaa.2 uc008oaa.3 Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation (By similarity). Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity). Together with RNF135 and UBE2N, catalyzes the viral RNA- dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. Heterodimer with UBE2N. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with TRAF6 (By similarity). Nucleus Note=Excluded from the nucleolus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZY3-1; Sequence=Displayed; Name=2; IsoId=Q9CZY3-2; Sequence=VSP_011528; Ubiquitous. Highly expressed in heart, brain, liver, skeletal msucle, kidney and testis. Detected at lower levels in lung and spleen. Belongs to the ubiquitin-conjugating enzyme family. ubiquitin ligase complex protein binding nucleus nucleoplasm cytoplasm postreplication repair ubiquitin conjugating enzyme complex ubiquitin conjugating enzyme binding macromolecular complex UBC13-UEV1A complex error-free postreplication DNA repair positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of NF-kappaB transcription factor activity ubiquitin conjugating enzyme activity protein K63-linked ubiquitination uc008oaa.1 uc008oaa.2 uc008oaa.3 
ENSMUST00000109212.3 Gm5431 ENSMUST00000109212.3 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. (from UniProt Q5NCB3) AK144287 ENSMUST00000109212.1 ENSMUST00000109212.2 Gm5431 Q5NCB3 Q5NCB3_MOUSE uc287xrp.1 uc287xrp.2 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. GTPase activity GTP binding endoplasmic reticulum membrane defense response membrane cellular response to interferon-beta uc287xrp.1 uc287xrp.2 
ENSMUST00000109214.8 Rnf114 ENSMUST00000109214.8 ring finger protein 114, transcript variant 1 (from RefSeq NM_030743.6) ENSMUST00000109214.1 ENSMUST00000109214.2 ENSMUST00000109214.3 ENSMUST00000109214.4 ENSMUST00000109214.5 ENSMUST00000109214.6 ENSMUST00000109214.7 NM_030743 Q3UFU8 Q8K5A2 Q9ET26 RN114_MOUSE Zfp228 Zfp313 Znf228 Znf313 uc008nzv.1 uc008nzv.2 E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation. Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C. This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling. Cytoplasm Nucleus Autoubiquitinated. Polyubiquitinated in the presence of E2 enzymes UBE2D1, UBE2D2 and UBE2D3, but only monoubiquitinated in the presence of UBE2E1. Mice show no significant difference of viral resistance or augmented antiviral responses compared to WT when both are infected with virus. nucleic acid binding nucleus cytoplasm cytosol plasma membrane multicellular organism development spermatogenesis protein ubiquitination transferase activity cell differentiation metal ion binding uc008nzv.1 uc008nzv.2 
ENSMUST00000109221.9 B4galt5 ENSMUST00000109221.9 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 (from RefSeq NM_019835.2) A2A5T7 B4GT5_MOUSE B4galt5 Bgt-5 ENSMUST00000109221.1 ENSMUST00000109221.2 ENSMUST00000109221.3 ENSMUST00000109221.4 ENSMUST00000109221.5 ENSMUST00000109221.6 ENSMUST00000109221.7 ENSMUST00000109221.8 NM_019835 Q9JMK0 uc008nzm.1 uc008nzm.2 uc008nzm.3 uc008nzm.4 Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:21057870, PubMed:23882130, PubMed:30114188). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (PubMed:30114188). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (PubMed:29415997). Essential for extraembryonic development during early embryogenesis (PubMed:20574042, PubMed:21057870). Reaction=a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D- galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:31495, ChEBI:CHEBI:15378, ChEBI:CHEBI:17950, ChEBI:CHEBI:22801, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914; EC=2.4.1.274; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31496; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Sphingolipid metabolism. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein. Golgi apparatus Note=Trans cisternae of Golgi stack. Highest levels in heart, brain, liver and kidney with lower levels in spleen, lung and testis. In the brain, expression increases after birth. Up-regulated in subcutaneous adipose tissue during obesity and diabetes (at protein level). Single knockout mice show early embryonic lethality (PubMed:20574042). Mice with conditional knockout in embryonic fibroblasts are born normally, grow to adulthood without apparent abnormalities but have reduced glucosylceramide beta-1,4- galactosyltransferase activity (PubMed:30114188). Double knockout mice of B4GALT5 and B4GALT6 genes develop normally during embryogenesis and perinatal stage (PubMed:30114188). However, they show growth retardation and motor deficits with hindlimb dysfunction at 2 weeks of age, and they all die by 4 weeks of age (PubMed:30114188). Axonal and myelin formation are remarkably impaired in the spinal cords and increased immature neurons in the cerebral cortices seen (PubMed:30114188). Glucosylceramide beta-1,4-galactosyltransferase activity and major brain gangliosides are completely absent in brain (PubMed:30114188). Knockdown in subcutaneous adipose tissue alleviates insulin resistance and adipose tissue inflammation, increases adipogenesis in high-fat diet (HFD)-fed mice and ob/ob mice and reduces the glycosylation of BMPR1A (PubMed:29415997). Belongs to the glycosyltransferase 7 family. Name=Functional Glycomics Gateway - GTase; Note=b4GalT5; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_464"; N-acetyllactosamine synthase activity Golgi apparatus carbohydrate metabolic process protein glycosylation lipid metabolic process sphingolipid metabolic process UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity ganglioside biosynthetic process via lactosylceramide membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups central nervous system neuron axonogenesis central nervous system myelination poly-N-acetyllactosamine biosynthetic process regulation of protein stability Golgi cisterna membrane positive regulation of embryonic development neuron maturation metal ion binding uc008nzm.1 uc008nzm.2 uc008nzm.3 uc008nzm.4 
ENSMUST00000109222.4 Chst4 ENSMUST00000109222.4 carbohydrate sulfotransferase 4, transcript variant 1 (from RefSeq NM_011998.5) A0A0R4J1C9 A0A0R4J1C9_MOUSE Chst4 ENSMUST00000109222.1 ENSMUST00000109222.2 ENSMUST00000109222.3 NM_011998 uc009njt.1 uc009njt.2 uc009njt.3 uc009njt.4 Membrane ; Single- pass type II membrane protein Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. Golgi membrane N-acetylglucosamine 6-O-sulfotransferase activity trans-Golgi network carbohydrate metabolic process N-acetylglucosamine metabolic process sulfur compound metabolic process sulfotransferase activity transferase activity uc009njt.1 uc009njt.2 uc009njt.3 uc009njt.4 
ENSMUST00000109226.5 Pelo ENSMUST00000109226.5 pelota mRNA surveillance and ribosome rescue factor (from RefSeq NM_134058.3) ENSMUST00000109226.1 ENSMUST00000109226.2 ENSMUST00000109226.3 ENSMUST00000109226.4 NM_134058 PELO_MOUSE Pelo Q3TCN0 Q6PG91 Q80X73 Q91UZ2 uc007ryb.1 uc007ryb.2 uc007ryb.3 uc007ryb.4 Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy. Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Component of the Pelota-HBS1L complex, also named Dom34-Hbs1 complex, composed of PELO and HBS1L. Interacts with PINK1. Interacts with ABCE1. Interacts with CNOT4. Q80X73; Q3UJK4: Gtpbp2; NbExp=3; IntAct=EBI-16114899, EBI-16114877; Q80X73; Q69ZS7: Hbs1l; NbExp=2; IntAct=EBI-16114899, EBI-16114976; Cytoplasm Ubiquitously expressed. Embryonic lethality due to defects in chromosome segregation during cell division, resulting in aneuploidy and loss of genomic stability. Belongs to the eukaryotic release factor 1 family. Pelota subfamily. inner cell mass cell proliferation nuclease activity endonuclease activity protein binding nucleus cytoplasm cell cycle endoderm development hydrolase activity stem cell population maintenance positive regulation of BMP signaling pathway ribosome disassembly ribosome binding metal ion binding chromosome organization cell division mesenchymal to epithelial transition nuclear-transcribed mRNA catabolic process, non-stop decay nonfunctional rRNA decay nuclear-transcribed mRNA catabolic process, no-go decay RNA surveillance nucleic acid phosphodiester bond hydrolysis uc007ryb.1 uc007ryb.2 uc007ryb.3 uc007ryb.4 
ENSMUST00000109228.2 Timd5 ENSMUST00000109228.2 T cell immunoglobulin and mucin domain containing 5 (from RefSeq NM_001163357.1) ENSMUST00000109228.1 F2Z474 F2Z474_MOUSE Gm12169 NM_001163357 Timd5 uc011xtr.1 uc011xtr.2 uc011xtr.3 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the immunoglobulin superfamily. TIM family. molecular_function cellular_component biological_process membrane integral component of membrane uc011xtr.1 uc011xtr.2 uc011xtr.3 
ENSMUST00000109236.9 Stau1 ENSMUST00000109236.9 staufen double-stranded RNA binding protein 1, transcript variant 3 (from RefSeq NM_011490.4) ENSMUST00000109236.1 ENSMUST00000109236.2 ENSMUST00000109236.3 ENSMUST00000109236.4 ENSMUST00000109236.5 ENSMUST00000109236.6 ENSMUST00000109236.7 ENSMUST00000109236.8 NM_011490 Q9Z108 STAU1_MOUSE Stau uc008nyv.1 uc008nyv.2 uc008nyv.3 uc008nyv.4 uc008nyv.5 Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. Binds tubulin. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner (By similarity). Cytoplasm Rough endoplasmic reticulum. Note=Localizes exclusively with the rough reticulum endoplasmic (RER). One of the DRDB could be involved in RER binding. The C-terminal contains the tubulin binding domain (TBD). RNA binding double-stranded RNA binding protein binding cytoplasm endoplasmic reticulum rough endoplasmic reticulum cytosol plasma membrane protein phosphatase 1 binding intracellular mRNA localization cytoplasmic stress granule dendrite dendrite cytoplasm cytoplasmic ribonucleoprotein granule neuron projection neuronal cell body cell body positive regulation of viral genome replication positive regulation by virus of viral protein levels in host cell modulation of synaptic transmission dendritic transport of messenger ribonucleoprotein complex glutamatergic synapse modification of postsynaptic structure positive regulation of long-term synaptic potentiation ribonucleoprotein complex uc008nyv.1 uc008nyv.2 uc008nyv.3 uc008nyv.4 uc008nyv.5 
ENSMUST00000109237.9 Itk ENSMUST00000109237.9 IL2 inducible T cell kinase, transcript variant 1 (from RefSeq NM_001281965.1) ENSMUST00000109237.1 ENSMUST00000109237.2 ENSMUST00000109237.3 ENSMUST00000109237.4 ENSMUST00000109237.5 ENSMUST00000109237.6 ENSMUST00000109237.7 ENSMUST00000109237.8 Emt ITK_MOUSE NM_001281965 Q03526 Tlk Tsk uc011xtn.1 uc011xtn.2 uc011xtn.3 uc011xtn.4 Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Required for TCR- mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2- positive subset of immature gamma-delta T-cells (PubMed:23562159). Phosphorylates TBX21 at 'Tyr-525' and mediates its interaction with GATA3 (PubMed:15662016). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Homooligomerizes; this association negatively regulates kinase activity. Interacts with PPIA/CYPA; this interaction regulates TCR signal strength via a proline-directed conformational switch in ITK. Interacts with THEMIS (By similarity). Interacts with FASLG. Interacts with VAV1; this interaction is important for VAV1 localization and TCR- induced actin polarization. Interacts with TBX21 (PubMed:15662016). Q03526; P08487: PLCG1; Xeno; NbExp=4; IntAct=EBI-647969, EBI-8013886; Cytoplasm. Nucleus Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Is detected in the thymus, lymph node and very faintly in the spleen, but is not detected in the liver, lung, kidney, heart, brain, intestine or testis. Expressed in T-lymphocytes and mast cells. It may also be expressed in natural killer cells. Is present in the fetal thymus as early as day 14 of gestation. The levels are 5- to 10-fold higher in thymocytes than in peripheral T-cells, and increase in the thymus during development from neonate to adult. Through a myriad of surface receptors including the TCR/CD3 signaling complex, coreceptors, or chemokine receptors. The N-terminal PH domain allows ITK to be recruited to the plasma membrane by an activated PI3 kinase. This domain contains also a proline-rich region (PRR). The adjoining domain is a SH3 domain, which binds to PRR (from itself or from other proteins). Next, a SH2 domain is required for binding tyrosine-phosphorylated substrates. In the C- terminal region, the kinase domain is required for tyrosine phosphorylation (By similarity). Phosphorylated at Tyr-517 in the activation loop of the kinase domain by LCK. Subsequent autophosphorylation at Tyr-186 leads to the kinase activation. The autophosphorylated Tyr-186 lies within the substrate binding sequence of the SH3 domain (By similarity). Ubiquitinated. Mice display decreased mature thymocytes and elicit profound defect in CD4+ and CD8+ T-cell development (PubMed:8777721, PubMed:10213685, PubMed:16860760, PubMed:21036902). Additionally, they show a strong decrease of cytokine production in response to TCR receptor stimulation (PubMed:21036902). Impaired TCR- mediated calcium response in gamma-delta T-cells (PubMed:23562159). Loss of Vgamma2-positive immature thymocyte-specific transcriptomic profile, although there is no change to overall transcription factor expression levels (PubMed:23562159). Not required for the generation of IL17A expressing gamma-delta T-cells (PubMed:23562159). Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. nucleotide binding cytokine production NK T cell differentiation adaptive immune response immune system process protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding nucleus cytoplasm cytosol cell-cell junction protein phosphorylation activation of phospholipase C activity kinase activity phosphorylation transferase activity interferon-gamma production interleukin-4 production intracellular signal transduction peptidyl-tyrosine autophosphorylation metal ion binding T cell receptor signaling pathway B cell receptor signaling pathway uc011xtn.1 uc011xtn.2 uc011xtn.3 uc011xtn.4 
ENSMUST00000109241.5 Snx18 ENSMUST00000109241.5 sorting nexin 18 (from RefSeq NM_130796.4) ENSMUST00000109241.1 ENSMUST00000109241.2 ENSMUST00000109241.3 ENSMUST00000109241.4 NM_130796 Q8C788 Q8C788_MOUSE Snag1 Snx18 uc007rxg.1 uc007rxg.2 uc007rxg.3 Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the sorting nexin family. mitotic cell cycle mitotic cytokinesis phosphatidylinositol-4,5-bisphosphate binding endocytosis protein transport membrane endosomal transport clathrin-coated vesicle cytoplasmic vesicle membrane extrinsic component of cytoplasmic side of plasma membrane cytoplasmic vesicle phosphatidylinositol binding cleavage furrow formation positive regulation of GTPase activity extracellular exosome uc007rxg.1 uc007rxg.2 uc007rxg.3 
ENSMUST00000109244.9 Cdc20b ENSMUST00000109244.9 cell division cycle 20B (from RefSeq NM_001281487.1) CD20B_MOUSE Cdc20b D3Z3I0 ENSMUST00000109244.1 ENSMUST00000109244.2 ENSMUST00000109244.3 ENSMUST00000109244.4 ENSMUST00000109244.5 ENSMUST00000109244.6 ENSMUST00000109244.7 ENSMUST00000109244.8 NM_001281487 uc033gng.1 uc033gng.2 uc033gng.3 Protein regulator of centriole-deuterosome disengagement and subsequently participates in the ciliogenesis in multiciliated cells (MCCs). Cytoplasm Note=Tightly associated to mature deuterosomes. Expressed in multiciliated cells (MCCs). Belongs to the WD repeat CDC20/Fizzy family. molecular_function cellular_component biological_process anaphase-promoting complex binding ubiquitin-protein transferase activator activity positive regulation of ubiquitin protein ligase activity uc033gng.1 uc033gng.2 uc033gng.3 
ENSMUST00000109249.9 Sulf2 ENSMUST00000109249.9 sulfatase 2, transcript variant 2 (from RefSeq NM_028072.5) B2RUD5 ENSMUST00000109249.1 ENSMUST00000109249.2 ENSMUST00000109249.3 ENSMUST00000109249.4 ENSMUST00000109249.5 ENSMUST00000109249.6 ENSMUST00000109249.7 ENSMUST00000109249.8 NM_028072 Q3TNM3 Q8BM68 Q8BUZ4 Q8BX28 Q8BZ51 Q8C169 Q8CFG0 Q9D8E2 SULF2_MOUSE uc008nyl.1 uc008nyl.2 uc008nyl.3 uc008nyl.4 Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (By similarity). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (By similarity). Reaction=an aryl sulfate + H2O = a phenol + H(+) + sulfate; Xref=Rhea:RHEA:17261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:33853, ChEBI:CHEBI:140317; EC=3.1.6.1; Evidence=; Reaction=Hydrolysis of the 6-sulfate groups of the N-acetyl-D- glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.; EC=3.1.6.14; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Endoplasmic reticulum Golgi apparatus, Golgi stack Cell surface [Extracellular sulfatase Sulf-2 secreted form]: Secreted Processing by furin produces a secreted form. Glycosylation at Ser-588 negatively regulates its N- acetylglucosamine-6-sulfatase and arylsulfatase activities. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. Belongs to the sulfatase family. Sequence=BAB25464.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; kidney development chondrocyte development glomerular filtration catalytic activity arylsulfatase activity calcium ion binding glycosaminoglycan binding extracellular space endoplasmic reticulum Golgi apparatus Golgi stack plasma membrane sulfur compound metabolic process N-acetylglucosamine-6-sulfatase activity sulfuric ester hydrolase activity response to wounding cell surface positive regulation of vascular endothelial growth factor production esophagus smooth muscle contraction hydrolase activity positive regulation of Wnt signaling pathway heparan sulfate proteoglycan metabolic process glomerular basement membrane development glial cell-derived neurotrophic factor receptor signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway metal ion binding embryonic skeletal system development cartilage development bone development innervation positive regulation of canonical Wnt signaling pathway liver regeneration regulation of hepatocyte proliferation uc008nyl.1 uc008nyl.2 uc008nyl.3 uc008nyl.4 
ENSMUST00000109261.11 Clint1 ENSMUST00000109261.11 clathrin interactor 1, transcript variant 7 (from RefSeq NM_001404782.1) Clint1 ENSMUST00000109261.1 ENSMUST00000109261.10 ENSMUST00000109261.2 ENSMUST00000109261.3 ENSMUST00000109261.4 ENSMUST00000109261.5 ENSMUST00000109261.6 ENSMUST00000109261.7 ENSMUST00000109261.8 ENSMUST00000109261.9 NM_001404782 Q5SUH6 Q5SUH6_MOUSE uc057kkt.1 uc057kkt.2 uc057kkt.3 uc057kkt.4 nucleoplasm Golgi apparatus membrane vesicle-mediated transport clathrin binding intracellular membrane-bounded organelle uc057kkt.1 uc057kkt.2 uc057kkt.3 uc057kkt.4 
ENSMUST00000109266.11 Zmynd8 ENSMUST00000109266.11 zinc finger, MYND-type containing 8, transcript variant 3 (from RefSeq NM_001252585.1) E9Q8D1 E9Q8D1_MOUSE ENSMUST00000109266.1 ENSMUST00000109266.10 ENSMUST00000109266.2 ENSMUST00000109266.3 ENSMUST00000109266.4 ENSMUST00000109266.5 ENSMUST00000109266.6 ENSMUST00000109266.7 ENSMUST00000109266.8 ENSMUST00000109266.9 NM_001252585 Zmynd8 uc008nya.1 uc008nya.2 uc008nya.3 transcription corepressor activity nucleus cytoplasm regulation of transcription, DNA-templated zinc ion binding protein domain specific binding negative regulation of cell migration methylated histone binding dendritic spine dendritic shaft metal ion binding protein N-terminus binding positive regulation of filopodium assembly positive regulation of dendritic spine development lysine-acetylated histone binding modulation of excitatory postsynaptic potential regulation of postsynaptic density protein 95 clustering positive regulation of dendritic spine maintenance negative regulation of nucleic acid-templated transcription uc008nya.1 uc008nya.2 uc008nya.3 
ENSMUST00000109267.9 Map3k1 ENSMUST00000109267.9 mitogen-activated protein kinase kinase kinase 1 (from RefSeq NM_011945.3) ENSMUST00000109267.1 ENSMUST00000109267.2 ENSMUST00000109267.3 ENSMUST00000109267.4 ENSMUST00000109267.5 ENSMUST00000109267.6 ENSMUST00000109267.7 ENSMUST00000109267.8 F8VQ72 F8VQ72_MOUSE Map3k1 NM_011945 uc007rwa.1 uc007rwa.2 uc007rwa.3 uc007rwa.4 protein kinase activity ATP binding protein phosphorylation zinc ion binding protein kinase binding cellular response to mechanical stimulus uc007rwa.1 uc007rwa.2 uc007rwa.3 uc007rwa.4 
ENSMUST00000109272.9 Mier3 ENSMUST00000109272.9 MIER family member 3 (from RefSeq NM_172593.3) ENSMUST00000109272.1 ENSMUST00000109272.2 ENSMUST00000109272.3 ENSMUST00000109272.4 ENSMUST00000109272.5 ENSMUST00000109272.6 ENSMUST00000109272.7 ENSMUST00000109272.8 MIER3_MOUSE NM_172593 Q3SYJ7 Q3UGR9 Q3UHF3 Q8BND7 Q8BSS0 uc007rvy.1 uc007rvy.2 uc007rvy.3 Transcriptional repressor. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UHF3-1; Sequence=Displayed; Name=2; IsoId=Q3UHF3-2; Sequence=VSP_030104, VSP_030105; Sequence=AAI03781.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding DNA binding transcription corepressor activity nucleus nucleoplasm macromolecular complex histone deacetylase binding uc007rvy.1 uc007rvy.2 uc007rvy.3 
ENSMUST00000109283.2 Slc2a13 ENSMUST00000109283.2 solute carrier family 2 (facilitated glucose transporter), member 13 (from RefSeq NM_001033633.3) ENSMUST00000109283.1 MYCT_MOUSE NM_001033633 Q3UHK1 Slc2a13 uc007xhy.1 uc007xhy.2 uc007xhy.3 uc007xhy.4 H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Reaction=H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in); Xref=Rhea:RHEA:60364, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268; Evidence=; Cell membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Sequence=BAE27856.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; myo-inositol:proton symporter activity plasma membrane integral component of plasma membrane myo-inositol transport membrane integral component of membrane transmembrane transporter activity transmembrane transport uc007xhy.1 uc007xhy.2 uc007xhy.3 uc007xhy.4 
ENSMUST00000109300.9 Slc35c2 ENSMUST00000109300.9 solute carrier family 35, member C2, transcript variant 2 (from RefSeq NM_144893.2) ENSMUST00000109300.1 ENSMUST00000109300.2 ENSMUST00000109300.3 ENSMUST00000109300.4 ENSMUST00000109300.5 ENSMUST00000109300.6 ENSMUST00000109300.7 ENSMUST00000109300.8 NM_144893 Ovcov1 Q8VCX2 S35C2_MOUSE uc008nxg.1 uc008nxg.2 uc008nxg.3 uc008nxg.4 May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells (By similarity). Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Higher expression at embryo stage 7.5 dpc than 11- 17 dpc. Belongs to the TPT transporter family. SLC35C subfamily. nucleoplasm endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cis-Golgi network negative regulation of gene expression antiporter activity UDP-glucose transport membrane integral component of membrane transmembrane transporter activity endoplasmic reticulum-Golgi intermediate compartment membrane fucosylation protein O-linked fucosylation positive regulation of Notch signaling pathway uc008nxg.1 uc008nxg.2 uc008nxg.3 uc008nxg.4 
ENSMUST00000109304.2 1700025C18Rik ENSMUST00000109304.2 RIKEN cDNA 1700025C18 gene (from RefSeq NR_033448.1) 1700025C18Rik A2A580 A2A580_MOUSE ENSMUST00000109304.1 NR_033448 uc012cjg.1 uc012cjg.2 uc012cjg.3 molecular_function cellular_component biological_process uc012cjg.1 uc012cjg.2 uc012cjg.3 
ENSMUST00000109308.3 Nfatc3 ENSMUST00000109308.3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3, transcript variant 1 (from RefSeq NM_010901.3) ENSMUST00000109308.1 ENSMUST00000109308.2 NM_010901 Nfatc3 Q3UZ64 Q3UZ64_MOUSE uc009nfd.1 uc009nfd.2 uc009nfd.3 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of vascular smooth muscle cell differentiation uc009nfd.1 uc009nfd.2 uc009nfd.3 
ENSMUST00000109309.9 Shank3 ENSMUST00000109309.9 SH3 and multiple ankyrin repeat domains 3 (from RefSeq NM_021423.4) ENSMUST00000109309.1 ENSMUST00000109309.2 ENSMUST00000109309.3 ENSMUST00000109309.4 ENSMUST00000109309.5 ENSMUST00000109309.6 ENSMUST00000109309.7 ENSMUST00000109309.8 F8S0X0 F8S0X2 F8S0X3 F8S0X5 F8S0X6 Kiaa1650 NM_021423 Prosap2 Q4ACU6 Q69ZD8 Q9JJZ3 S6BMD3 S6CCV8 SHAN3_MOUSE uc289arm.1 uc289arm.2 uc289arm.3 Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. May homomultimerize via its SAM domain. Interacts with BAIAP2, DBNL and SLC17A7/VGLUT1. Interacts with DLGAP1/GKAP, GRM1/MGLUR1, GRM5/MGLUR5 and LZTS3 C-termini via its PDZ domain. Interacts with ABI1, HOMER1, HOMER2, HOMER3 and CTTN/cortactin SH3 domain. Is part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts (via PDZ domain) with the GRIA1 subunit of the AMPA receptor (via PDZ-binding motif). Interacts with WASF1 and CYFIP2; the interactions mediate the association of SHANK3 with the WAVE1 complex. Interacts with ARPC2; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex. Interacts (via ANK repeats) with SHARPIN and SPTAN1. Interacts (via PDZ domain) with ARHGAP44 (probably via PDZ-binding motif); the interaction takes place in dendritic spines and promotes GRIA1 exocytosis. Interacts with CAMK2A (By similarity). Interacts with DIP2A (PubMed:31600191). Q4ACU6; Q8BKX1: Baiap2; NbExp=6; IntAct=EBI-771450, EBI-771498; Q4ACU6; Q5SQX6: Cyfip2; NbExp=3; IntAct=EBI-771450, EBI-773783; Q4ACU6; Q91XM9: Dlg2; NbExp=4; IntAct=EBI-771450, EBI-400138; Q4ACU6; Q9D415: Dlgap1; NbExp=4; IntAct=EBI-771450, EBI-400152; Q4ACU6; Q9Z2Y3: Homer1; NbExp=8; IntAct=EBI-771450, EBI-396980; Q4ACU6-1; O60741: HCN1; Xeno; NbExp=4; IntAct=EBI-16201983, EBI-11173743; Q4ACU6-1; Q9UL51: HCN2; Xeno; NbExp=3; IntAct=EBI-16201983, EBI-1751885; Q4ACU6-1; Q9P1Z3: HCN3; Xeno; NbExp=3; IntAct=EBI-16201983, EBI-11178054; Cytoplasm. Synapse. Postsynaptic density. Cell projection, dendritic spine Note=In neuronal cells, extends into the region subjacent to the postsynaptic density (PSD). Event=Alternative promoter usage, Alternative splicing; Named isoforms=10; Comment=Additional isoform seem to exist. These isoforms may be the product of multiple intragenic promoter and/or alternative splicing. ; Name=1; Synonyms=A, Alpha; IsoId=Q4ACU6-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q4ACU6-2; Sequence=VSP_053612, VSP_053613, VSP_053614, VSP_053615; Name=4; Synonyms=C3, Beta; IsoId=Q4ACU6-3; Sequence=VSP_053611; Name=5; Synonyms=C4; IsoId=Q4ACU6-6; Sequence=VSP_053611, VSP_053614, VSP_053615; Name=6; Synonyms=D1; IsoId=Q4ACU6-7; Sequence=VSP_053609; Name=7; Synonyms=D2; IsoId=Q4ACU6-8; Sequence=VSP_053608; Name=8; Synonyms=E1; IsoId=Q4ACU6-9; Sequence=VSP_053607; Name=9; Synonyms=E2; IsoId=Q4ACU6-10; Sequence=VSP_053607, VSP_053613; Name=3; Synonyms=C1; IsoId=Q4ACU6-11; Sequence=VSP_053610; Name=10; Synonyms=F; IsoId=Q4ACU6-12; Sequence=VSP_053606; In brain, highly expressed in striatum, thalamus, hippocampus and granule cells of the cerebellum. Isoform 3 is weakly expressed at 17 dpc but its expression increases after birth. In isoform 1, the N-terminal region preceding the ANK repeats interacts with the 6 ANK repeats in an intramolecular manner, thereby restricting access to ligands, such as SHARPIN and SPTAN1. Animals deficient for isoforms 1-7 exhibit self- injourious repetitive grooming and deficits in social interaction. They show defects at striatal synapses and cortico-striatal circuits with an increase in striatal volume, dendritic length, and surface area and a decrease of spine density, length and thickness of PSD. They seem to have an altered molecular composition of postsynaptic machinery in the striatum (PubMed:21423165). In contrast, animals deficient for isoforms 1 and 2 exhibit a normal initiation of social interaction with a perturbed recognition of social novelty (PubMed:21423165). In PubMed:21558424, animals deficient for isoforms 1 and 2 show abnormal social behaviors, communication patterns, repetitive behaviors, learning and memory. In CA1 hippocampus, the synaptic plasticity is impaired with longer dendritic spines, decreased spine density and deficient long-term potentiation. The expression of specific synaptic scaffolding proteins and receptor subunits are altered. Animals deficient for isoforms 1-5 exhibit self-injourious repetitive grooming, brain-region-specific up-regulation of ionotropic glutamate receptors and increased levels of SHANK2 (PubMed:22699619). Animals deficient for predominant isoforms containing exon 21 exhibit motor-coordination deficits, hypersensitivity to heat, novelty avoidance, altered locomotor response to novelty and minimal social abnormalities. They show a decrease in NMDA-AMPA excitatory postsynaptic current ratio in hippocampal CA1, reduced long-term potentiation and deficits in hippocampus-dependent spatial learning and memory (PubMed:24259569). [Isoform 2]: Produced by alternative promoter usage and alternative splicing. [Isoform 4]: Produced by alternative splicing of isoform 3. [Isoform 5]: Produced by alternative splicing of isoform 3. [Isoform 6]: Produced by alternative promoter usage. [Isoform 7]: Produced by alternative splicing of isoform 6. [Isoform 8]: Produced by alternative promoter usage. [Isoform 9]: Produced by alternative splicing of isoform 8. [Isoform 3]: Produced by alternative promoter usage. [Isoform 10]: Produced by alternative promoter usage. Belongs to the SHANK family. MAPK cascade embryonic epithelial tube formation actin binding protein binding cytoplasm plasma membrane synapse assembly learning or memory learning memory locomotory behavior protein C-terminus binding zinc ion binding postsynaptic density membrane SH3 domain binding striatal medium spiny neuron differentiation cell junction receptor signaling complex scaffold activity GKAP/Homer scaffold activity dendrite adult behavior extrinsic component of cytoplasmic side of plasma membrane negative regulation of actin filament bundle assembly social behavior ionotropic glutamate receptor binding exploration behavior locomotory exploration behavior locomotion vocal learning identical protein binding cell projection neuron projection dendritic spine protein self-association neuron spine synapse postsynaptic membrane negative regulation of cell volume regulation of synaptic plasticity positive regulation of long-term neuronal synaptic plasticity brain morphogenesis regulation of synapse organization neuromuscular process controlling balance synaptic growth at neuromuscular junction protein oligomerization positive regulation of synapse structural plasticity positive regulation of synaptic transmission, glutamatergic excitatory synapse ciliary membrane long-term synaptic potentiation long term synaptic depression dendritic spine morphogenesis positive regulation of dendritic spine development regulation of dendritic spine morphogenesis vocalization behavior postsynaptic density assembly scaffold protein binding AMPA glutamate receptor clustering NMDA glutamate receptor clustering guanylate kinase-associated protein clustering structural constituent of postsynaptic density glutamatergic synapse postsynaptic density, intracellular component maintenance of postsynaptic density structure regulation of long-term synaptic potentiation positive regulation of long-term synaptic potentiation positive regulation of glutamate receptor signaling pathway regulation of long term synaptic depression regulation of AMPA glutamate receptor clustering regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential regulation of grooming behavior regulation of behavioral fear response positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity ionotropic glutamate receptor complex uc289arm.1 uc289arm.2 uc289arm.3 
ENSMUST00000109313.9 Cpt1b ENSMUST00000109313.9 carnitine palmitoyltransferase 1b, muscle (from RefSeq NM_009948.2) CPT1B_MOUSE ENSMUST00000109313.1 ENSMUST00000109313.2 ENSMUST00000109313.3 ENSMUST00000109313.4 ENSMUST00000109313.5 ENSMUST00000109313.6 ENSMUST00000109313.7 ENSMUST00000109313.8 NM_009948 O35287 Q924X2 Q9QYP4 uc007xgr.1 uc007xgr.2 uc007xgr.3 Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Reaction=(R)-carnitine + hexadecanoyl-CoA = CoA + O-hexadecanoyl-(R)- carnitine; Xref=Rhea:RHEA:12661, ChEBI:CHEBI:16347, ChEBI:CHEBI:17490, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=2.3.1.21; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12662; Evidence=; Lipid metabolism; fatty acid beta-oxidation. Mitochondrion outer membrane ; Multi-pass membrane protein Belongs to the carnitine/choline acetyltransferase family. carnitine O-palmitoyltransferase activity mitochondrion mitochondrial outer membrane lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation carnitine metabolic process long-chain fatty acid transport membrane integral component of membrane transferase activity transferase activity, transferring acyl groups intracellular membrane-bounded organelle uc007xgr.1 uc007xgr.2 uc007xgr.3 
ENSMUST00000109315.5 Nln ENSMUST00000109315.5 neurolysin (metallopeptidase M3 family) (from RefSeq NM_029447.2) ENSMUST00000109315.1 ENSMUST00000109315.2 ENSMUST00000109315.3 ENSMUST00000109315.4 NEUL_MOUSE NM_029447 Q3UJP1 Q8R3F4 Q91YP2 uc007rsp.1 uc007rsp.2 uc007rsp.3 Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1. Reaction=Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.; EC=3.4.24.16; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Mitochondrion intermembrane space Cytoplasm, cytosol Belongs to the peptidase M3 family. metalloendopeptidase activity cytoplasm mitochondrion mitochondrial intermembrane space cytosol plasma membrane regulation of gluconeogenesis proteolysis peptide metabolic process peptidase activity metallopeptidase activity hydrolase activity peptide binding metal ion binding oligopeptidase activity regulation of skeletal muscle fiber differentiation uc007rsp.1 uc007rsp.2 uc007rsp.3 
ENSMUST00000109331.9 Plxnb2 ENSMUST00000109331.9 plexin B2, transcript variant 2 (from RefSeq NM_138749.4) B2RXS4 ENSMUST00000109331.1 ENSMUST00000109331.2 ENSMUST00000109331.3 ENSMUST00000109331.4 ENSMUST00000109331.5 ENSMUST00000109331.6 ENSMUST00000109331.7 ENSMUST00000109331.8 NM_138749 PLXB2_MOUSE Q3UH76 uc007xfr.1 uc007xfr.2 uc007xfr.3 uc007xfr.4 Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (PubMed:17554007). Plays a role in glutamatergic synapse development and is required for SEMA4A- mediated excitatory synapse development (PubMed:29981480). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (PubMed:17554007). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (PubMed:19948886). Regulates the migration of cerebellar granule cells in the developing brain (PubMed:21122816). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (By similarity). Plays a role in axon guidance, invasive growth and cell migration (By similarity). May modulate the activity of RAC1 and CDC42 (PubMed:21966369). Down-regulates macrophage migration in wound-healing assays (in vitro) (PubMed:21966369). Monomer, and heterodimer with PLXNB1 (By similarity). Interacts with MET, ARHGEF11 and ARHGEF12 (By similarity). May also interact with MST1R (By similarity). Interacts with SEMA4C (PubMed:17554007, PubMed:21122816). Interacts with SEMA4D (PubMed:17554007). Interacts with SEMA4G (PubMed:21122816). B2RXS4; Q68FM7: Arhgef11; NbExp=2; IntAct=EBI-8496724, EBI-2365869; Cell membrane ; Single-pass type I membrane protein Detected in macrophages from spleen and bone marrow (at protein level) (PubMed:21966369). Detected in granule cells in the developing cerebellum, dentate gyrus and olfactory bulb (PubMed:17554007). Expressed in neurons and glia in the developing hippocampus (PubMed:29981480). Embryonic and perinatal lethality, due to defects in brain and neural tube development. Mice exhibit abnormal cortical layering and defective migration and differentiation of several subtypes of cortical neurons. Cranial neural folds fail to converge in most embryos, leading to an open neural tube and exencephaly. Likewise, mice exhibit defects in the embryonic development of the cerebellum and the olfactory bulb. Belongs to the plexin family. neural tube closure regulation of protein phosphorylation semaphorin receptor complex protein binding plasma membrane integral component of plasma membrane homophilic cell adhesion via plasma membrane adhesion molecules negative regulation of cell adhesion signal transduction multicellular organism development neuroblast proliferation brain development regulation of cell shape positive regulation of neuron projection development membrane integral component of membrane semaphorin receptor activity regulation of cell migration regulation of GTPase activity positive regulation of axonogenesis semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway involved in axon guidance excitatory synapse assembly regulation of neuron migration uc007xfr.1 uc007xfr.2 uc007xfr.3 uc007xfr.4 
ENSMUST00000109332.8 Wfdc11 ENSMUST00000109332.8 WAP four-disulfide core domain 11, transcript variant 2 (from RefSeq NM_001413736.1) A2A5H7 ENSMUST00000109332.1 ENSMUST00000109332.2 ENSMUST00000109332.3 ENSMUST00000109332.4 ENSMUST00000109332.5 ENSMUST00000109332.6 ENSMUST00000109332.7 NM_001413736 WFD11_MOUSE uc008nvp.1 uc008nvp.2 Secreted Although this protein was isolated in a region containing several WAP proteins and was defined as a WAP protein, it does not contain a classical WAP domain. molecular_function cellular_component extracellular region biological_process uc008nvp.1 uc008nvp.2 
ENSMUST00000109333.8 Mrps36 ENSMUST00000109333.8 mitochondrial ribosomal protein S36, transcript variant 1 (from RefSeq NM_025369.3) ENSMUST00000109333.1 ENSMUST00000109333.2 ENSMUST00000109333.3 ENSMUST00000109333.4 ENSMUST00000109333.5 ENSMUST00000109333.6 ENSMUST00000109333.7 KGD4_MOUSE Kgd4 Mrps36 NM_025369 Q4VA25 Q9CQX8 uc007rrl.1 uc007rrl.2 uc007rrl.3 uc007rrl.4 Molecular adapter that is necessary to form a stable 2- oxoglutarate dehydrogenase enzyme complex (OGDHC). Enables the specific recruitment of E3 subunit to E2 subunit in the 2-oxoglutarate dehydrogenase complex (OGDHC). Component of the 2-oxoglutarate dehydrogenase complex (OGDHC), composed of OGDH (2-oxoglutarate dehydrogenase; also called E1 subunit), DLST (dihydrolipoamide succinyltransferase; also called E2 subunit) and DLD (dihydrolipoamide dehydrogenase; also called E3 subunit), and the assembly factor KGD4. Within OGDHC complex, interacts (via N-terminus) with E3 subunit and (via C-terminus) with E2 subunit. Mitochondrion Belongs to the alpha-ketoglutarate dehydrogenase component 4 family. Was originally identified in the small subunit (28S) of mitochondrial ribosomes that were purified on sucrose gradients (By similarity). This observation has been challenged by experiments showing KGD4 copurification with the oxoglutarate dehydrogenase complex (OGDHC), also called alpha-ketoglutarate dehydrogenase complex (KGDH). Both mitochondrial ribosome 28S subunit and OGDC have a similar size and OGDC is highly abundant, therefore OGDC has been found to contaminate ribosomal preparations performed by sequential centrifugation steps (PubMed:25165143). In addition, KGD4 could not be located in the structure of the human mitochondrial ribosome, supporting the hypothesis that it is not a mitoribosomal protein (By similarity). mitochondrion mitochondrial small ribosomal subunit ribosome 2-oxoglutarate metabolic process mitochondrial oxoglutarate dehydrogenase complex oxidation-reduction process oxoglutarate dehydrogenase (succinyl-transferring) activity uc007rrl.1 uc007rrl.2 uc007rrl.3 uc007rrl.4 
ENSMUST00000109335.8 Wfdc9 ENSMUST00000109335.8 WAP four-disulfide core domain 9 (from RefSeq NM_001160414.2) ENSMUST00000109335.1 ENSMUST00000109335.2 ENSMUST00000109335.3 ENSMUST00000109335.4 ENSMUST00000109335.5 ENSMUST00000109335.6 ENSMUST00000109335.7 NM_001160414 Q3UW41 WFDC9_MOUSE uc290ckt.1 uc290ckt.2 Secreted molecular_function cellular_component extracellular region biological_process uc290ckt.1 uc290ckt.2 
ENSMUST00000109336.2 Wfdc16 ENSMUST00000109336.2 WAP four-disulfide core domain 16 (from RefSeq NM_001012723.2) A2A5H4 A2A5H4_MOUSE ENSMUST00000109336.1 NM_001012723 Wfdc16 uc012cjc.1 uc012cjc.2 uc012cjc.3 molecular_function cellular_component extracellular region biological_process negative regulation of peptidase activity peptidase inhibitor activity uc012cjc.1 uc012cjc.2 uc012cjc.3 
ENSMUST00000109338.2 Wfdc8 ENSMUST00000109338.2 WAP four-disulfide core domain 8, transcript variant 2 (from RefSeq NM_001080550.3) ENSMUST00000109338.1 Gm706 NM_001080550 Q4KUS1 WFDC8_MOUSE uc008nvk.1 uc008nvk.2 uc008nvk.3 uc008nvk.4 Membrane ; Single-pass membrane protein molecular_function serine-type endopeptidase inhibitor activity cellular_component extracellular region biological_process negative regulation of peptidase activity negative regulation of endopeptidase activity membrane integral component of membrane peptidase inhibitor activity uc008nvk.1 uc008nvk.2 uc008nvk.3 uc008nvk.4 
ENSMUST00000109342.2 Wfdc6a ENSMUST00000109342.2 WAP four-disulfide core domain 6A, transcript variant 2 (from RefSeq NM_001033240.4) ENSMUST00000109342.1 Gm122 NM_001033240 Q3UW55 WFC6A_MOUSE uc012cjb.1 uc012cjb.2 Secreted molecular_function serine-type endopeptidase inhibitor activity extracellular region extracellular space cell surface negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity macromolecular complex defense response to bacterium protein oligomerization negative regulation of calcium ion import negative regulation of flagellated sperm motility uc012cjb.1 uc012cjb.2 
ENSMUST00000109345.9 Wfdc2 ENSMUST00000109345.9 WAP four-disulfide core domain 2, transcript variant 2 (from RefSeq NM_001374655.1) A2A5G5 A2A5G5_MOUSE ENSMUST00000109345.1 ENSMUST00000109345.2 ENSMUST00000109345.3 ENSMUST00000109345.4 ENSMUST00000109345.5 ENSMUST00000109345.6 ENSMUST00000109345.7 ENSMUST00000109345.8 NM_001374655 Wfdc2 uc290cko.1 uc290cko.2 Homotrimer; disulfide-linked. extracellular region negative regulation of peptidase activity peptidase inhibitor activity uc290cko.1 uc290cko.2 
ENSMUST00000109349.9 Dbndd2 ENSMUST00000109349.9 dysbindin domain containing 2, transcript variant 4 (from RefSeq NM_001048229.1) D2Bwg0891e DBND2_MOUSE ENSMUST00000109349.1 ENSMUST00000109349.2 ENSMUST00000109349.3 ENSMUST00000109349.4 ENSMUST00000109349.5 ENSMUST00000109349.6 ENSMUST00000109349.7 ENSMUST00000109349.8 NM_001048229 Q9CRD4 uc008nuz.1 uc008nuz.2 uc008nuz.3 May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro) (By similarity). Monomer. Interacts with CSNK1D and CSNK1E (By similarity). Belongs to the dysbindin family. molecular_function cytoplasm negative regulation of protein kinase activity uc008nuz.1 uc008nuz.2 uc008nuz.3 
ENSMUST00000109352.8 Sys1 ENSMUST00000109352.8 Involved in protein trafficking. May serve as a receptor for ARFRP1 (By similarity). (from UniProt Q78S06) AK013220 ENSMUST00000109352.1 ENSMUST00000109352.2 ENSMUST00000109352.3 ENSMUST00000109352.4 ENSMUST00000109352.5 ENSMUST00000109352.6 ENSMUST00000109352.7 Q3UFU1 Q78S06 Q9DAU8 SYS1_MOUSE uc290ckb.1 uc290ckb.2 Involved in protein trafficking. May serve as a receptor for ARFRP1 (By similarity). Interacts with ARFRP1. Golgi apparatus membrane ; Multi- pass membrane protein Belongs to the SYS1 family. Golgi membrane molecular_function Golgi apparatus trans-Golgi network cytosol Golgi to endosome transport protein transport membrane integral component of membrane integral component of Golgi membrane protein localization to Golgi apparatus Golgi to plasma membrane protein transport uc290ckb.1 uc290ckb.2 
ENSMUST00000109353.9 Tubgcp6 ENSMUST00000109353.9 tubulin, gamma complex component 6 (from RefSeq NM_001163319.1) ENSMUST00000109353.1 ENSMUST00000109353.2 ENSMUST00000109353.3 ENSMUST00000109353.4 ENSMUST00000109353.5 ENSMUST00000109353.6 ENSMUST00000109353.7 ENSMUST00000109353.8 G5E8P0 GCP6_MOUSE Kiaa1669 NM_001163319 Q6PFC6 Q6ZPK3 Q8BWI2 uc007xfh.1 uc007xfh.2 uc007xfh.3 uc007xfh.4 Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=G5E8P0-1; Sequence=Displayed; Name=2; IsoId=G5E8P0-2; Sequence=VSP_058269, VSP_058270; Belongs to the TUBGCP family. Sequence=BAC98230.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; microtubule cytoskeleton organization mitotic cell cycle spindle pole equatorial microtubule organizing center gamma-tubulin complex cytoplasm centrosome microtubule organizing center cytoskeleton microtubule microtubule nucleation microtubule binding gamma-tubulin ring complex cytoplasmic microtubule organization gamma-tubulin binding spindle assembly meiotic cell cycle interphase microtubule nucleation by interphase microtubule organizing center microtubule minus-end binding uc007xfh.1 uc007xfh.2 uc007xfh.3 uc007xfh.4 
ENSMUST00000109355.9 Lrrc36 ENSMUST00000109355.9 leucine rich repeat containing 36, transcript variant 1 (from RefSeq NM_001170788.1) ENSMUST00000109355.1 ENSMUST00000109355.2 ENSMUST00000109355.3 ENSMUST00000109355.4 ENSMUST00000109355.5 ENSMUST00000109355.6 ENSMUST00000109355.7 ENSMUST00000109355.8 F8WI85 F8WI85_MOUSE Lrrc36 NM_001170788 uc012gjj.1 uc012gjj.2 uc012gjj.1 uc012gjj.2 
ENSMUST00000109367.10 Slpi ENSMUST00000109367.10 secretory leukocyte peptidase inhibitor, transcript variant 1 (from RefSeq NM_011414.4) ENSMUST00000109367.1 ENSMUST00000109367.2 ENSMUST00000109367.3 ENSMUST00000109367.4 ENSMUST00000109367.5 ENSMUST00000109367.6 ENSMUST00000109367.7 ENSMUST00000109367.8 ENSMUST00000109367.9 NM_011414 Q548X8 Q548X8_MOUSE Slpi uc008nuj.1 uc008nuj.2 DNA binding mRNA binding endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity extracellular region extracellular space proteolysis peptidase activity negative regulation of peptidase activity negative regulation of endopeptidase activity antibacterial humoral response enzyme binding peptidase inhibitor activity negative regulation of protein binding modification of morphology or physiology of other organism negative regulation of viral genome replication uc008nuj.1 uc008nuj.2 
ENSMUST00000109371.8 Ttll8 ENSMUST00000109371.8 tubulin tyrosine ligase-like family, member 8, transcript variant 1 (from RefSeq NM_172818.3) A4Q9F1 ENSMUST00000109371.1 ENSMUST00000109371.2 ENSMUST00000109371.3 ENSMUST00000109371.4 ENSMUST00000109371.5 ENSMUST00000109371.6 ENSMUST00000109371.7 NM_172818 Q14B76 Q8C0N7 TTLL8_MOUSE Ttll8 uc007xet.1 uc007xet.2 uc007xet.3 uc007xet.4 Monoglycylase which modifies both tubulin and non-tubulin proteins, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of target proteins (PubMed:19524510, PubMed:28576883). Not involved in elongation step of the polyglycylation reaction (PubMed:19524510). Preferentially monoglycylates alpha-tubulin over beta-tubulin (PubMed:19524510). Together with TTLL3, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance (PubMed:19524510, PubMed:23897886, PubMed:25180231). Together with TTLL3, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility (PubMed:33414192). Monoglycylates non- tubulin proteins such as ANP32A, ANP32B, SET, NCL and NAP1 (PubMed:19524510, PubMed:19427864). Reaction=ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L- glutamyl-[protein] + H(+) + phosphate; Xref=Rhea:RHEA:67180, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:17207, ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:167890, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67181; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm, cytoskeleton ll projection, cilium Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme Highly expressed in testis (PubMed:17499049, PubMed:25180231). Expressed in brain, heart, kidney, liver, lung, muscle, spleen and trachea (PubMed:17499049, PubMed:25180231, PubMed:33414192). Expressed in sperm flagellum (PubMed:33414192). In the brain, specifically expressed in ependymal cilia (PubMed:23897886). Two conserved structural elements specific among monoglycylases, IS1 and IS2, are involved in glycyl chains initiation. Two conserved structural interfaces likely constitute the binding platforms for tubulin tail and microtubule. Arg-403 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate- chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation. Simultaneous TTLL3 and TTLL8 knockout mice are subfertile owing to aberrant beat patterns of their sperm flagella, which impeded the straight swimming of sperm cells. TTLL3 and TTLL8 monoglycylase-mediated glycylation of tubulin was initially reported to play a role in ependymal motile ciliary maintenance (PubMed:23897886). However, contradictory results were later observed (PubMed:33414192). Sequence=AAI16294.1; Type=Erroneous initiation; Evidence=; Sequence=AAI16295.1; Type=Frameshift; Evidence=; Sequence=BAC26811.1; Type=Erroneous initiation; Evidence=; nucleotide binding ATP binding cytoplasm cytoskeleton microtubule cilium axoneme cellular protein modification process microtubule cytoskeleton ligase activity protein polyglycylation cell projection cilium assembly protein-glycine ligase activity protein-glycine ligase activity, initiating uc007xet.1 uc007xet.2 uc007xet.3 uc007xet.4 
ENSMUST00000109375.4 Elmo3 ENSMUST00000109375.4 engulfment and cell motility 3 (from RefSeq NM_172760.4) ELMO3_MOUSE ENSMUST00000109375.1 ENSMUST00000109375.2 ENSMUST00000109375.3 NM_172760 Q6PDE4 Q8BYZ7 uc009ncn.1 uc009ncn.2 uc009ncn.3 uc009ncn.4 Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). Probably interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1 (By similarity). Interacts with ADGRB3 (By similarity). Q8BYZ7; Q8BUR4: Dock1; NbExp=4; IntAct=EBI-646035, EBI-646023; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BYZ7-1; Sequence=Displayed; Name=2; IsoId=Q8BYZ7-2; Sequence=VSP_037343; protein binding cellular_component cytoplasm phagocytosis apoptotic process biological_process cell migration SH3 domain binding uc009ncn.1 uc009ncn.2 uc009ncn.3 uc009ncn.4 
ENSMUST00000109376.9 Wfdc15b ENSMUST00000109376.9 WAP four-disulfide core domain 15B, transcript variant 1 (from RefSeq NM_138685.2) A2A5M6 ENSMUST00000109376.1 ENSMUST00000109376.2 ENSMUST00000109376.3 ENSMUST00000109376.4 ENSMUST00000109376.5 ENSMUST00000109376.6 ENSMUST00000109376.7 ENSMUST00000109376.8 NM_138685 Q8BVC0 Q9JHY4 Swam1 WF15B_MOUSE Wfdc15 uc008ntz.1 uc008ntz.2 uc008ntz.3 Antibacterial protein which inhibits the growth of E.coli and S.aureus. Secreted Constitutively expressed in kidney and epididymis. By intranasal administration of S.pneumoniae. molecular_function cellular_component extracellular region biological_process negative regulation of peptidase activity peptidase inhibitor activity defense response to bacterium uc008ntz.1 uc008ntz.2 uc008ntz.3 
ENSMUST00000109381.9 Brd1 ENSMUST00000109381.9 bromodomain containing 1 (from RefSeq NM_001033274.3) BRD1_MOUSE Brd1 Brpf2 E9PZ26 ENSMUST00000109381.1 ENSMUST00000109381.2 ENSMUST00000109381.3 ENSMUST00000109381.4 ENSMUST00000109381.5 ENSMUST00000109381.6 ENSMUST00000109381.7 ENSMUST00000109381.8 G5E8P1 Kiaa4191 NM_001033274 Q571F6 Q8BU83 uc007xek.1 uc007xek.2 uc007xek.3 uc007xek.4 Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:21753189). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). Component of some HBO1 complexes composed of KAT7/HBO1, MEAF6, ING4 and BRD1/BRPF2 (PubMed:21753189). Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3 (By similarity). Interacts (via PHD-type zinc finger domain) with unmodified histone H3 (By similarity). Interacts (via PWWP domain) with dimethylated and trimethylated 'Lys- 79' on histone H3 (By similarity). Nucleus Chromosome Note=Localizes to transcription start sites. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=G5E8P1-1; Sequence=Displayed; Name=2; IsoId=G5E8P1-2; Sequence=VSP_060568; Embryos die at mid-gestation because of anemia and impaired fetal liver erythropoiesis. nucleus nuclear speck dendrite histone binding perikaryon histone H3 acetylation metal ion binding MOZ/MORF histone acetyltransferase complex uc007xek.1 uc007xek.2 uc007xek.3 uc007xek.4 
ENSMUST00000109384.10 Tomm34 ENSMUST00000109384.10 translocase of outer mitochondrial membrane 34, transcript variant Tom34a (from RefSeq NM_001291155.1) A2A5N5 A2A5N6 ENSMUST00000109384.1 ENSMUST00000109384.2 ENSMUST00000109384.3 ENSMUST00000109384.4 ENSMUST00000109384.5 ENSMUST00000109384.6 ENSMUST00000109384.7 ENSMUST00000109384.8 ENSMUST00000109384.9 NM_001291155 Q3THD0 Q812F1 Q812F2 Q9CYG7 Q9D059 TOM34_MOUSE uc008nts.1 uc008nts.2 uc008nts.3 Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state (By similarity). Interacts with HSP90A, VCP, ATP6V1D, KIAA0665, AMPK, and DMAP1 through its TPR repeat. Cytoplasm Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side Event=Alternative splicing; Named isoforms=2; Comment=Isoforms 1 and 2 are produced by 2 alternative initial coding exons with very similar sequences which differ at only 4 positions.; Name=1; Synonyms=Tomm34a; IsoId=Q9CYG7-1; Sequence=Displayed; Name=2; Synonyms=Tomm34b; IsoId=Q9CYG7-2; Sequence=VSP_035044; Isoform 1 is ubiquitously expressed while isoform 2 is expressed only in mature testicular germ cells. Isoform 1 is expressed in all testicular cells. Isoform 2 is highly expressed in early to late pachytene cells but expression is significantly decreased in round spermatid cells. Isoform 2 is hardly detectable in testis at 1 week post partum but expression gradually increases for 2 to 4 weeks post partum. Isoform 1 is detected during this period but its expression does not change. Mice are viable, grow normally and both males and females are fertile. There is no effect on spermatogenesis or protein import into mitochondria. Belongs to the Tom34 family. protein binding nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane cytosol protein targeting to mitochondrion membrane heat shock protein binding uc008nts.1 uc008nts.2 uc008nts.3 
ENSMUST00000109396.2 Kcnk15 ENSMUST00000109396.2 Membrane ulti-pass membrane protein (from UniProt A2AHD2) A2AHD2 A2AHD2_MOUSE BC147255 ENSMUST00000109396.1 Kcnk15 uc290cjc.1 uc290cjc.2 Membrane ulti-pass membrane protein Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. integral component of plasma membrane ion transport potassium ion transport membrane integral component of membrane potassium ion leak channel activity stabilization of membrane potential potassium ion transmembrane transport potassium channel activity uc290cjc.1 uc290cjc.2 
ENSMUST00000109399.9 Tnpo1 ENSMUST00000109399.9 transportin 1, transcript variant 6 (from RefSeq NM_001426415.1) ENSMUST00000109399.1 ENSMUST00000109399.2 ENSMUST00000109399.3 ENSMUST00000109399.4 ENSMUST00000109399.5 ENSMUST00000109399.6 ENSMUST00000109399.7 ENSMUST00000109399.8 Kpnb2 NM_001426415 Q8BFY9 Q8C0S3 Q8K2E7 TNPO1_MOUSE uc007rpe.1 uc007rpe.2 uc007rpe.3 Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11493596). May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (By similarity). In vitro, mediates nuclear import of SRP19 (By similarity). Mediates the import of histones H2A, H2B, H3 and H4 (PubMed:11493596). Mediates nuclear import of ADAR/ADAR1 in a RanGTP- dependent manner (By similarity). Identified in a complex that contains TNPO1, RAN and RANBP1 (By similarity). Binds HNRPA1, HNRPA2, HNRNPDL, RPS7, RPL5 and RAN. Interacts with H2A, H2B, H3 and H4 histones (PubMed:11493596). Interacts with isoform 1 and isoform 5 of ADAR/ADAR1 (via DRBM 3 domain). Interacts with SNAI1 (via zinc fingers); the interaction mediates SNAI1 nuclear import. Interacts with SNAI2 (via zinc fingers) (By similarity). Interacts with RPL23A (via BIB domain) and SRP19; this interaction is involved in RPL23A and SRP19 import into the nucleus (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BFY9-1; Sequence=Displayed; Name=2; IsoId=Q8BFY9-2; Sequence=VSP_038030; Belongs to the importin beta family. Importin beta-2 subfamily. Sequence=BAC26696.1; Type=Erroneous initiation; Evidence=; Sequence=BAC27029.1; Type=Erroneous initiation; Evidence=; protein binding nucleus cytoplasm protein import into nucleus intracellular protein transport nuclear localization sequence binding Ran GTPase binding protein transport nuclear import signal receptor activity uc007rpe.1 uc007rpe.2 uc007rpe.3 
ENSMUST00000109412.9 Cpeb4 ENSMUST00000109412.9 cytoplasmic polyadenylation element binding protein 4, transcript variant 3 (from RefSeq NM_001290678.1) Cpeb4 ENSMUST00000109412.1 ENSMUST00000109412.2 ENSMUST00000109412.3 ENSMUST00000109412.4 ENSMUST00000109412.5 ENSMUST00000109412.6 ENSMUST00000109412.7 ENSMUST00000109412.8 NM_001290678 Q5SU48 Q5SU48_MOUSE uc287xgj.1 uc287xgj.2 Belongs to the RRM CPEB family. nucleic acid binding RNA binding mRNA 3'-UTR binding regulation of translation translation regulator activity uc287xgj.1 uc287xgj.2 
ENSMUST00000109416.3 R3hdml ENSMUST00000109416.3 R3H domain containing-like (from RefSeq NM_001099331.2) A2A5I3 CRSPL_MOUSE ENSMUST00000109416.1 ENSMUST00000109416.2 NM_001099331 uc008nsw.1 uc008nsw.2 uc008nsw.3 Putative serine protease inhibitor. Secreted Belongs to the CRISP family. Despite its name, it does not contain a R3H domain. molecular_function extracellular region extracellular space biological_process negative regulation of peptidase activity peptidase inhibitor activity uc008nsw.1 uc008nsw.2 uc008nsw.3 
ENSMUST00000109418.2 Fitm2 ENSMUST00000109418.2 fat storage-inducing transmembrane protein 2 (from RefSeq NM_173397.4) B9EHX3 ENSMUST00000109418.1 FITM2_MOUSE Fit2 Fitm2 NM_173397 P59266 Q5BKP7 uc057bpb.1 uc057bpb.2 uc057bpb.3 Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'- bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl-CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (PubMed:18160536, PubMed:26504167) (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (PubMed:22106267) (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Reaction=an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'- phosphopantetheine + 2 H(+); Xref=Rhea:RHEA:50044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58342, ChEBI:CHEBI:58343, ChEBI:CHEBI:132023; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50045; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine; Xref=Rhea:RHEA:65564, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57387, ChEBI:CHEBI:58343, ChEBI:CHEBI:156553; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65565; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'- bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'- phosphopantetheine; Xref=Rhea:RHEA:65568, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57368, ChEBI:CHEBI:58343, ChEBI:CHEBI:156554; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65569; Evidence=; Reaction=H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50032, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57379, ChEBI:CHEBI:58343, ChEBI:CHEBI:132018; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50033; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Widely expressed, with highest levels in white and brown adipose tissues (at protein level). In the heart, mRNA expression levels do not correlate well with protein levels, suggesting post- transcriptional regulation in this organ. Homozygous knockout mice display embryonic lethality (PubMed:30923760). Heterozygous knockout mice exhibit shortened left ventricular end-diastolic dimension and shortened left ventricular end-systolic dimension (PubMed:30923760). They also exhibit improved profiles upon pressure overload-induced heart failure (PubMed:30923760). Belongs to the FIT family. molecular_function mitochondrion endoplasmic reticulum endoplasmic reticulum membrane cytoskeleton organization phospholipid biosynthetic process regulation of triglyceride biosynthetic process positive regulation of sequestering of triglyceride membrane integral component of membrane lipid storage regulation of cell morphogenesis integral component of endoplasmic reticulum membrane sequestering of triglyceride lipid particle organization cellular triglyceride homeostasis uc057bpb.1 uc057bpb.2 uc057bpb.3 
ENSMUST00000109420.10 Gdap1l1 ENSMUST00000109420.10 ganglioside-induced differentiation-associated protein 1-like 1, transcript variant 4 (from RefSeq NR_176072.1) ENSMUST00000109420.1 ENSMUST00000109420.2 ENSMUST00000109420.3 ENSMUST00000109420.4 ENSMUST00000109420.5 ENSMUST00000109420.6 ENSMUST00000109420.7 ENSMUST00000109420.8 ENSMUST00000109420.9 Gdap1l1 NR_176072 Q3USC7 Q3USC7_MOUSE uc290cif.1 uc290cif.2 Belongs to the GST superfamily. membrane integral component of membrane uc290cif.1 uc290cif.2 
ENSMUST00000109422.8 Ppara ENSMUST00000109422.8 peroxisome proliferator activated receptor alpha, transcript variant 1 (from RefSeq NM_011144.6) ENSMUST00000109422.1 ENSMUST00000109422.2 ENSMUST00000109422.3 ENSMUST00000109422.4 ENSMUST00000109422.5 ENSMUST00000109422.6 ENSMUST00000109422.7 NM_011144 Ppara Q542P9 Q542P9_MOUSE uc007xdk.1 uc007xdk.2 uc007xdk.3 uc007xdk.4 Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. Nucleus Belongs to the nuclear hormone receptor family. NR1 subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II repressing transcription factor binding transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding response to hypoxia DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated fatty acid metabolic process heart development transcription factor binding drug binding zinc ion binding lipid binding negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of sequestering of triglyceride phosphatase binding protein domain specific binding intracellular receptor signaling pathway ubiquitin conjugating enzyme binding negative regulation of protein binding response to insulin behavioral response to nicotine lipoprotein metabolic process steroid hormone mediated signaling pathway sequence-specific DNA binding macromolecular complex binding negative regulation of blood pressure positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding negative regulation of inflammatory response NFAT protein binding negative regulation of cell growth involved in cardiac muscle cell development regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter MDM2/MDM4 family protein binding negative regulation of neuron death negative regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of leukocyte cell-cell adhesion uc007xdk.1 uc007xdk.2 uc007xdk.3 uc007xdk.4 
ENSMUST00000109424.4 Wnt7b ENSMUST00000109424.4 wingless-type MMTV integration site family, member 7B, transcript variant 1 (from RefSeq NM_009528.3) ENSMUST00000109424.1 ENSMUST00000109424.2 ENSMUST00000109424.3 NM_009528 P28047 Q80US5 WNT7B_MOUSE Wnt-7b uc007xdf.1 uc007xdf.2 uc007xdf.3 uc007xdf.4 Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (PubMed:15923619, PubMed:28803732). Required for normal fusion of the chorion and the allantois during placenta development (PubMed:11543617). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:28803732). Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD1 and FZD10 (PubMed:15923619). Interacts with FZD4 (in vitro) (PubMed:15923619). Interacts with PORCN (PubMed:10866835). Interacts with glypican GPC3 (By similarity). Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (By similarity). Secreted, extracellular space, extracellular matrix Secreted At 7.5 and 8.5 dpc, detected in extraembryonic membranes and cells that form the chorionic plate. The intrinsically disordered linker region is required for recognition by RECK in brain endothelial cells. Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. Belongs to the Wnt family. angiogenesis in utero embryonic development vasculature development metanephros morphogenesis receptor binding frizzled binding extracellular region extracellular space cytoplasm endoplasmic reticulum lumen plasma membrane activation of JUN kinase activity multicellular organism development positive regulation of cell proliferation cell surface positive regulation of gene expression Wnt signaling pathway establishment or maintenance of polarity of embryonic epithelium cell proliferation in forebrain forebrain regionalization central nervous system vasculogenesis neuron differentiation lung development neuron projection development oxygen homeostasis regulation of cell projection size chemoattraction of dopaminergic neuron axon odontogenesis of dentin-containing tooth homeostatic process cellular metabolic process cell fate commitment positive regulation of osteoblast differentiation negative regulation of smoothened signaling pathway positive regulation of JNK cascade receptor agonist activity embryonic organ development neuron projection morphogenesis stem cell development negative regulation of neurogenesis synapse organization smooth muscle cell differentiation anatomical structure regression canonical Wnt signaling pathway lung morphogenesis lung epithelium development lobar bronchus development lung-associated mesenchyme development trachea cartilage morphogenesis developmental growth involved in morphogenesis embryonic placenta morphogenesis chorio-allantoic fusion renal inner medulla development renal outer medulla development outer medullary collecting duct development inner medullary collecting duct development metanephric collecting duct development metanephric epithelium development metanephric loop of Henle development apoptotic process involved in blood vessel morphogenesis chemoattractant activity involved in axon guidance planar cell polarity pathway involved in axon guidance uc007xdf.1 uc007xdf.2 uc007xdf.3 uc007xdf.4 
ENSMUST00000109425.3 Jph2 ENSMUST00000109425.3 junctophilin 2, transcript variant 2 (from RefSeq NM_001205076.1) ENSMUST00000109425.1 ENSMUST00000109425.2 JPH2_MOUSE Jp2 Jph2 NM_001205076 Q3U077 Q9ET78 Q9ET79 uc029uhy.1 uc029uhy.2 [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:10949023, PubMed:19095005, PubMed:21339484). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (PubMed:10949023, PubMed:19095005, PubMed:21339484). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (PubMed:10949023, PubMed:19095005, PubMed:21339484). Contributes to the construction of skeletal muscle triad junctions (PubMed:10949023). [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress (PubMed:30409805). Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes (PubMed:30409805). Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis (PubMed:30409805). Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress (PubMed:30409805). Probably acts by competing with MEF2 transcription factors and TATA-binding proteins (PubMed:30409805). Interacts with TRPC3 (By similarity). Interacts with BAG5 and HSPA8; the interaction with HSPA8 is increased in the presence of BAG5 (By similarity). [Junctophilin-2 N-terminal fragment]: Interacts with MEF2C (PubMed:30409805). Q9ET78; G1U2U3: TRPC3; Xeno; NbExp=4; IntAct=EBI-8350389, EBI-10055313; [Junctophilin-2]: Cell membrane ; Peripheral membrane protein Sarcoplasmic reticulum membrane ; Single-pass type IV membrane protein Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Note=The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (PubMed:10949023). In heart cells, it predominantly associates along Z lines within myocytes (PubMed:10949023). In skeletal muscle, it is specifically localized at the junction of A and I bands (PubMed:10949023). [Junctophilin-2 N-terminal fragment]: Nucleus Note=Accumulates in the nucleus of stressed hearts. Abundantly expressed in skeletal muscle and heart (PubMed:10949023). Weak expression in stomach and lung (PubMed:10949023). At 9.5 dpc, it is expressed in the periphery of cardiac myocytes in the looped cardiac tube of the developing heart (PubMed:10949023). In skeletal muscle, expression increases during muscle maturation (PubMed:10949023). [Junctophilin-2]: The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, by interacting with phospholipids. Has affinity for phosphatidylserine, and phosphorylated phosphatidylinositols including PtdIns3P, PtdIns4P, PtdIns5P, PtdIns(3,5)P2 and PtdIns(3,4,5)P3. [Junctophilin-2 N-terminal fragment]: The bipartite nuclear localization signal (bNLS) and Ala-rich (alanine-rich; ARR) regions are involved in DNA-binding. Proteolytically cleaved by calpain in response to cardiac stress (PubMed:26063807). The major cleavage site takes place at the C- terminus and leads to the release of the Junctophilin-2 N-terminal fragment chain (JP2NT) (PubMed:26063807, PubMed:30409805). Phosphorylation on Ser-165, probably by PKC, affects RYR1-mediated calcium ion release, interaction with TRPC3, and skeletal muscle myotubule development. Null mice possess cardiomyocytes with deficiencies in the junctional membrane complexes and have abnormal Ca(2+) transients (PubMed:10949023, PubMed:19095005, PubMed:21339484). Mice die from cardiac arrest at 10.5 dpc (PubMed:10949023). Belongs to the junctophilin family. negative regulation of transcription from RNA polymerase II promoter core promoter binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding phosphatidylserine binding DNA binding protein binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding nucleus endoplasmic reticulum endoplasmic reticulum membrane plasma membrane positive regulation of cytosolic calcium ion concentration multicellular organism development phosphatidylinositol-5-phosphate binding calcium-release channel activity membrane integral component of membrane sarcoplasmic reticulum Z disc junctional membrane complex phosphatidylinositol-3-phosphate binding sarcoplasmic reticulum membrane negative regulation of transcription, DNA-templated release of sequestered calcium ion into cytosol regulation of cardiac muscle tissue development calcium ion homeostasis positive regulation of ryanodine-sensitive calcium-release channel activity phosphatidylinositol-4-phosphate binding phosphatidic acid binding phosphatidylinositol-3,5-bisphosphate binding uc029uhy.1 uc029uhy.2 
ENSMUST00000109428.9 Tox2 ENSMUST00000109428.9 TOX high mobility group box family member 2, transcript variant 14 (from RefSeq NM_001407355.1) A2A473 A2A473_MOUSE ENSMUST00000109428.1 ENSMUST00000109428.2 ENSMUST00000109428.3 ENSMUST00000109428.4 ENSMUST00000109428.5 ENSMUST00000109428.6 ENSMUST00000109428.7 ENSMUST00000109428.8 NM_001407355 Tox2 uc290chv.1 uc290chv.2 Nucleus RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus nucleoplasm positive regulation of transcription from RNA polymerase II promoter uc290chv.1 uc290chv.2 
ENSMUST00000109430.2 Gpr75 ENSMUST00000109430.2 G protein-coupled receptor 75 (from RefSeq NM_175490.4) ENSMUST00000109430.1 GPR75_MOUSE NM_175490 Q3URC1 Q6X632 Q8BXP3 uc007iib.1 uc007iib.2 uc007iib.3 uc007iib.4 G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. Cell membrane; Multi-pass membrane protein Highly expressed in brain and heart. Also detected in skeletal muscle, liver and kidney. Also expressed by islet cells (at protein level). Expressed at 7 dpc and 11 dpc. Also detected at 17 dpc. Belongs to the G-protein coupled receptor 1 family. Sequence=BAC31978.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane C-C chemokine receptor activity chemokine-mediated signaling pathway regulation of neuron death uc007iib.1 uc007iib.2 uc007iib.3 uc007iib.4 
ENSMUST00000109443.8 Ptprt ENSMUST00000109443.8 protein tyrosine phosphatase receptor type T, transcript variant 5 (from RefSeq NM_001420773.1) ENSMUST00000109443.1 ENSMUST00000109443.2 ENSMUST00000109443.3 ENSMUST00000109443.4 ENSMUST00000109443.5 ENSMUST00000109443.6 ENSMUST00000109443.7 NM_001420773 PTPRT_MOUSE Q99M80 Q99M81 Q99M82 Q9JIZ1 Q9JIZ2 Q9JKC2 Q9JLP0 uc008nry.1 uc008nry.2 uc008nry.3 uc008nry.4 May be involved in both signal transduction and cellular adhesion in the CNS. May have specific signaling roles in the tyrosine phosphorylation/dephosphorylation pathway in the anterior compartment of the adult cerebellar cortex. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q99M80-1; Sequence=Displayed; Name=2; IsoId=Q99M80-2; Sequence=VSP_007803, VSP_007806; Name=3; Synonyms=RPTPrho2; IsoId=Q99M80-3; Sequence=VSP_007803, VSP_007804; Name=4; Synonyms=RPTPrho1; IsoId=Q99M80-4; Sequence=VSP_007803; Name=5; IsoId=Q99M80-5; Sequence=VSP_007803, VSP_007805; Expression is restricted to the CNS. Distributed throughout the brain and spinal cord. Exceptionally high levels found in the cortex and olfactory bulbs during perinatal development and are down-regulated during postnatal week 2. Expression in the cerebellar cortex is restricted to the granule cell layer of lobules 1-6. Anterior and posterior compartments become discernible only during postnatal weeks 2 and 6. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity plasma membrane integral component of plasma membrane protein dephosphorylation homophilic cell adhesion via plasma membrane adhesion molecules transmembrane receptor protein tyrosine kinase signaling pathway beta-catenin binding cell surface membrane integral component of membrane dephosphorylation hydrolase activity thiolester hydrolase activity phosphatase activity protein phosphatase binding negative regulation of cell migration peptidyl-tyrosine dephosphorylation protein homodimerization activity alpha-catenin binding gamma-catenin binding cadherin binding regulation of synapse organization alpha-actinin binding delta-catenin binding cellular response to interleukin-6 STAT family protein binding glutamatergic synapse integral component of postsynaptic density membrane negative regulation of STAT cascade peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity uc008nry.1 uc008nry.2 uc008nry.3 uc008nry.4 
ENSMUST00000109444.3 Cert1 ENSMUST00000109444.3 ceramide transporter 1, transcript variant 2 (from RefSeq NM_001164222.1) CERT_MOUSE Cert Col4a3bp ENSMUST00000109444.1 ENSMUST00000109444.2 NM_001164222 Q3TQF6 Q8BNN8 Q8C8H3 Q8CAR3 Q91WB1 Q9CU52 Q9EQG8 Q9EQG9 Stard11 uc007rnl.1 uc007rnl.2 uc007rnl.3 Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. Reaction=N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4- enine(out); Xref=Rhea:RHEA:45720, ChEBI:CHEBI:72959; Evidence=; Interacts with VAPA and VAPB. Interaction with VAPB is less efficient than with VAPA. Interacts (via FFAT motif) with MOSPD2 (via MSP domain). Cytoplasm Golgi apparatus Endoplasmic reticulum Note=Preferentially localized to the Golgi apparatus. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9EQG9-1; Sequence=Displayed; Name=2; Synonyms=Delta26, GPBPD26, CERT ; IsoId=Q9EQG9-2; Sequence=VSP_006277; Name=3; IsoId=Q9EQG9-3; Sequence=VSP_028735, VSP_028736; The START domain recognizes ceramides and diacylglycerol lipids, interacts with membranes, and mediates the intermembrane transfer of ceramides and diacylglycerol lipids. The PH domain targets the Golgi apparatus. The FFAT motif is required for interaction with VAPA, VAPB and MOSPD2. Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. [Isoform 3]: May be due to intron retention. Sequence=AAH16197.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; cell morphogenesis in utero embryonic development heart morphogenesis nucleoplasm cytoplasm mitochondrion endoplasmic reticulum Golgi apparatus cytosol ceramide metabolic process lipid transport muscle contraction endoplasmic reticulum organization signal transduction cell proliferation lipid binding kinase activity phosphorylation response to endoplasmic reticulum stress ER to Golgi ceramide transport ceramide transport perinuclear region of cytoplasm lipid homeostasis phosphatidylinositol-4-phosphate binding mitochondrion morphogenesis ceramide binding ceramide 1-phosphate binding ceramide 1-phosphate transporter activity ceramide 1-phosphate transport uc007rnl.1 uc007rnl.2 uc007rnl.3 
ENSMUST00000109456.9 Lpin3 ENSMUST00000109456.9 lipin 3, transcript variant 1 (from RefSeq NM_022883.3) ENSMUST00000109456.1 ENSMUST00000109456.2 ENSMUST00000109456.3 ENSMUST00000109456.4 ENSMUST00000109456.5 ENSMUST00000109456.6 ENSMUST00000109456.7 ENSMUST00000109456.8 LPIN3_MOUSE Lpin3 NM_022883 Q3TQ75 Q8C7R9 Q99PI4 uc008nrh.1 uc008nrh.2 uc008nrh.3 uc008nrh.4 Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn- glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27430; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by N-ethylmaleimide. Nucleus Significant expression in intestine and other regions of the gastrointestinal tract. Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity. Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif. Belongs to the lipin family. transcription coactivator activity nucleus lipid metabolic process fatty acid metabolic process phosphatidate phosphatase activity fatty acid catabolic process dephosphorylation hydrolase activity triglyceride biosynthetic process cellular response to insulin stimulus positive regulation of transcription from RNA polymerase II promoter uc008nrh.1 uc008nrh.2 uc008nrh.3 uc008nrh.4 
ENSMUST00000109462.8 Plcg1 ENSMUST00000109462.8 Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (from UniProt A2A4A6) A2A4A6 A2A4A6_MOUSE BC057161 ENSMUST00000109462.1 ENSMUST00000109462.2 ENSMUST00000109462.3 ENSMUST00000109462.4 ENSMUST00000109462.5 ENSMUST00000109462.6 ENSMUST00000109462.7 Plcg1 uc008nrd.1 uc008nrd.2 uc008nrd.3 Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33180; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; phosphatidylinositol phospholipase C activity calcium ion binding lipid metabolic process signal transduction phosphoric diester hydrolase activity phospholipid catabolic process lipid catabolic process hydrolase activity intracellular signal transduction uc008nrd.1 uc008nrd.2 uc008nrd.3 
ENSMUST00000109468.3 Top1 ENSMUST00000109468.3 topoisomerase (DNA) I, transcript variant 1 (from RefSeq NM_009408.3) A2A4B7 ENSMUST00000109468.1 ENSMUST00000109468.2 NM_009408 Q04750 TOP1_MOUSE Top-1 uc008nqy.1 uc008nqy.2 uc008nqy.3 uc008nqy.4 Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Regulates the alternative splicing of tissue factor (F3) pre- mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the BMAL1 promoter. Reaction=ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.; EC=5.6.2.1; Evidence= Monomer (By similarity). Interacts with ERCC6 (By similarity). Nucleus, nucleolus Nucleus, nucleoplasm Note=Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumoylated forms found in both nucleoplasm and nucleoli. Sumoylated. Lys-119 is the main site of sumoylation. Sumoylation plays a role in partitioning TOP1 between nucleoli and nucleoplasm. Levels are dramatically increased on camptothecin (CPT) treatment. Phosphorylation at Ser-508 by CK2 increases binding to supercoiled DNA and sensitivity to camptothecin. Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils. Belongs to the type IB topoisomerase family. nuclear chromosome P-body RNA polymerase II core promoter proximal region sequence-specific DNA binding fibrillar center dense fibrillar component DNA binding chromatin binding double-stranded DNA binding single-stranded DNA binding DNA topoisomerase activity DNA topoisomerase type I activity protein serine/threonine kinase activity ATP binding nucleus nucleoplasm chromosome nucleolus cytoplasm DNA replication DNA topological change chromatin remodeling chromosome segregation circadian rhythm rRNA transcription DNA topoisomerase complex (ATP-hydrolyzing) isomerase activity peptidyl-serine phosphorylation protein domain specific binding replication fork protection complex chromatin DNA binding circadian regulation of gene expression protein-DNA complex embryonic cleavage response to drug perikaryon macromolecular complex binding rhythmic process supercoiled DNA binding uc008nqy.1 uc008nqy.2 uc008nqy.3 uc008nqy.4 
ENSMUST00000109478.9 Dhx35 ENSMUST00000109478.9 DEAH-box helicase 35, transcript variant 3 (from RefSeq NM_001372513.2) A2ACQ1 A2ACQ1_MOUSE Dhx35 ENSMUST00000109478.1 ENSMUST00000109478.2 ENSMUST00000109478.3 ENSMUST00000109478.4 ENSMUST00000109478.5 ENSMUST00000109478.6 ENSMUST00000109478.7 ENSMUST00000109478.8 NM_001372513 uc290cek.1 uc290cek.2 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; nucleotide binding in utero embryonic development RNA binding helicase activity ATP binding hydrolase activity catalytic step 2 spliceosome uc290cek.1 uc290cek.2 
ENSMUST00000109486.9 Ralgapb ENSMUST00000109486.9 Ral GTPase activating protein, beta subunit (non-catalytic), transcript variant 2 (from RefSeq NM_001291138.1) A2ACC6 A2ACC6_MOUSE ENSMUST00000109486.1 ENSMUST00000109486.2 ENSMUST00000109486.3 ENSMUST00000109486.4 ENSMUST00000109486.5 ENSMUST00000109486.6 ENSMUST00000109486.7 ENSMUST00000109486.8 NM_001291138 Ralgapb uc012cig.1 uc012cig.2 uc012cig.3 GTPase activator activity positive regulation of GTPase activity regulation of small GTPase mediated signal transduction uc012cig.1 uc012cig.2 uc012cig.3 
ENSMUST00000109488.8 Snhg11 ENSMUST00000109488.8 small nucleolar RNA host gene 11 (from RefSeq NR_164123.1) ENSMUST00000109488.1 ENSMUST00000109488.2 ENSMUST00000109488.3 ENSMUST00000109488.4 ENSMUST00000109488.5 ENSMUST00000109488.6 ENSMUST00000109488.7 NR_164123 Q4G0K9 Q4G0K9_MOUSE Snhg11 uc008nqd.1 uc008nqd.2 molecular_function cellular_component biological_process uc008nqd.1 uc008nqd.2 
ENSMUST00000109506.3 1700060C20Rik ENSMUST00000109506.3 RIKEN cDNA 1700060C20 gene (from RefSeq NR_036606.2) ENSMUST00000109506.1 ENSMUST00000109506.2 NR_036606 uc008npu.1 uc008npu.2 uc008npu.3 uc008npu.4 uc008npu.5 uc008npu.1 uc008npu.2 uc008npu.3 uc008npu.4 uc008npu.5 
ENSMUST00000109511.8 5730522E02Rik ENSMUST00000109511.8 5730522E02Rik (from geneSymbol) 5730522E02Rik AK017784 ENSMUST00000109511.1 ENSMUST00000109511.2 ENSMUST00000109511.3 ENSMUST00000109511.4 ENSMUST00000109511.5 ENSMUST00000109511.6 ENSMUST00000109511.7 Q5SP45 Q5SP45_MOUSE uc287xbi.1 uc287xbi.2 molecular_function cellular_component biological_process uc287xbi.1 uc287xbi.2 
ENSMUST00000109514.8 Bcl11a ENSMUST00000109514.8 BCL11 transcription factor A, transcript variant 4 (from RefSeq NM_001242934.1) Bcl11a ENSMUST00000109514.1 ENSMUST00000109514.2 ENSMUST00000109514.3 ENSMUST00000109514.4 ENSMUST00000109514.5 ENSMUST00000109514.6 ENSMUST00000109514.7 NM_001242934 Q5STS9 Q5STS9_MOUSE uc007ift.1 uc007ift.2 uc007ift.3 uc007ift.4 uc007ift.5 Nucleus negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding nucleus nucleoplasm cytoplasm positive regulation of gene expression postsynaptic density protein kinase binding negative regulation of dendrite extension negative regulation of neuron remodeling cellular response to L-glutamate negative regulation of dendrite development negative regulation of branching morphogenesis of a nerve uc007ift.1 uc007ift.2 uc007ift.3 uc007ift.4 uc007ift.5 
ENSMUST00000109515.3 Cyp2d34 ENSMUST00000109515.3 cytochrome P450, family 2, subfamily d, polypeptide 34 (from RefSeq NM_145474.2) Cyp2d34 ENSMUST00000109515.1 ENSMUST00000109515.2 L7N463 L7N463_MOUSE NM_145474 uc007wzi.1 uc007wzi.2 uc007wzi.3 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane Microsome membrane Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen arachidonic acid metabolic process heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc007wzi.1 uc007wzi.2 uc007wzi.3 
ENSMUST00000109521.4 Polr2c ENSMUST00000109521.4 polymerase (RNA) II (DNA directed) polypeptide C (from RefSeq NM_009090.5) ENSMUST00000109521.1 ENSMUST00000109521.2 ENSMUST00000109521.3 NM_009090 P97760 Polr2c Q99M46 RPB3_MOUSE Rpo2-3 uc009mxe.1 uc009mxe.2 uc009mxe.3 uc009mxe.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB11/POLR2J and RPB3/POLR2C subunits interact with each other. Nucleus Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. DNA binding DNA-directed 5'-3' RNA polymerase activity protein binding nucleus nucleoplasm DNA-directed RNA polymerase II, core complex cytoplasm cytosol transcription, DNA-templated transcription from RNA polymerase II promoter microtubule cytoskeleton protein dimerization activity RNA polymerase II activity uc009mxe.1 uc009mxe.2 uc009mxe.3 uc009mxe.4 
ENSMUST00000109523.2 Vstm2l ENSMUST00000109523.2 V-set and transmembrane domain containing 2-like (from RefSeq NM_198627.2) A2ACD2 A2ACD2_MOUSE ENSMUST00000109523.1 NM_198627 Vstm2l uc012cic.1 uc012cic.2 extracellular region cytoplasm negative regulation of neuron apoptotic process uc012cic.1 uc012cic.2 
ENSMUST00000109525.8 Pus10 ENSMUST00000109525.8 pseudouridylate synthase 10, transcript variant 1 (from RefSeq NM_028956.5) Ccdc139 ENSMUST00000109525.1 ENSMUST00000109525.2 ENSMUST00000109525.3 ENSMUST00000109525.4 ENSMUST00000109525.5 ENSMUST00000109525.6 ENSMUST00000109525.7 NM_028956 PUS10_MOUSE Pus10 Q3UM90 Q8BSZ4 Q8CDM2 Q9CSI7 Q9D3U0 uc007ifl.1 uc007ifl.2 Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm. In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs. tRNA pseudouridylate synthase activity is enhanced by the presence of 1- methyladenosine at position 53-61 of tRNAs. Does not show tRNA pseudouridylate synthase activity in the nucleus. In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity. Binds pri-miRNAs. Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death. Reaction=uridine(55) in tRNA = pseudouridine(55) in tRNA; Xref=Rhea:RHEA:42532, Rhea:RHEA-COMP:10101, Rhea:RHEA-COMP:10102, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.25; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42533; Evidence=; Reaction=uridine(54) in tRNA = pseudouridine(54) in tRNA; Xref=Rhea:RHEA:57876, Rhea:RHEA-COMP:10193, Rhea:RHEA-COMP:14141, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57877; Evidence=; Interacts with components of the microprocessor complex DROSHA and DGCR8. Nucleus Cytoplasm Mitochondrion Note=Localizes mainly in the nucleus. tRNA pseudouridylate synthase activity is restricted to the cytoplasm. Translocates from nucleus to mitochondria during TRAIL-induced apoptosis. Proteolytically cleaved during TRAIL-induced cell death. Cleaved, in vitro, either by caspase-3 (CASP3) or caspase-8 (CASP8). Belongs to the pseudouridine synthase Pus10 family. pseudouridine synthesis RNA binding cellular_component tRNA processing RNA modification pseudouridine synthase activity isomerase activity tRNA pseudouridine synthesis uc007ifl.1 uc007ifl.2 
ENSMUST00000109526.2 Nnat ENSMUST00000109526.2 neuronatin, transcript variant 1 (from RefSeq NM_010923.3) ENSMUST00000109526.1 NM_010923 NNAT_MOUSE Q548Q0 Q61979 Q61980 Q61981 uc008npe.1 uc008npe.2 uc008npe.3 uc008npe.4 May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61979-1; Sequence=Displayed; Name=2; IsoId=Q61979-3; Sequence=VSP_004333; Highest in brain and ovary. Expressed in rhombomeres 3 and 5 during early hindbrain development and in the floor of the foregut pocket. Also expressed in the early Rathke pouch, derived adenohypophysis, and developing inner ear. During later embryogenesis, strongly expressed in the major part of the central and peripheral nervous system. Belongs to the neuronatin family. Sequence=CAA58551.1; Type=Miscellaneous discrepancy; Note=Incorrect N-terminal sequence due to reversal of the first 22 base pairs of the cDNA.; Evidence=; cytoplasm multicellular organism development brain development response to glucose positive regulation of insulin secretion regulation of protein localization uc008npe.1 uc008npe.2 uc008npe.3 uc008npe.4 
ENSMUST00000109533.8 Src ENSMUST00000109533.8 Rous sarcoma oncogene, transcript variant 14 (from RefSeq NM_001421000.1) ENSMUST00000109533.1 ENSMUST00000109533.2 ENSMUST00000109533.3 ENSMUST00000109533.4 ENSMUST00000109533.5 ENSMUST00000109533.6 ENSMUST00000109533.7 F8WI90 NM_001421000 P05480 Q2M4I4 SRC_MOUSE Src uc290cbf.1 uc290cbf.2 Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (By similarity). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta- catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (PubMed:9344858). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation (By similarity). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta- arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (By similarity). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-738'. Enhances RIGI-elicited antiviral signaling. Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376'. Phosphorylates BCAR1 at 'Tyr-226'. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity. Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage- independent cell growth (By similarity). Required for podosome formation (PubMed:21525037). Mediates IL6 signaling by activating YAP1- NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (By similarity). [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr- 418 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= [Isoform 1]: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; [Isoform 2]: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Phosphorylation by CSK at Tyr-529 inhibits kinase activity. Inhibitory phosphorylation at Tyr-529 is enhanced by heme. Further phosphorylation by CDK1 partially reactivates CSK-inactivated SRC and facilitates complete reactivation by protein tyrosine phosphatase PTPRC. Integrin engagement stimulates kinase activity. Phosphorylation by PTK2/FAK1 enhances kinase activity. Butein and pseudosubstrate-based peptide inhibitors like CIYKYYF act as inhibitors. Phosphorylation at Tyr-418 increases kinase activity. Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain) and SRC; the formation of the complex is dependent on integrin mediated-tyrosine phosphorylation of PTPRA (PubMed:22801373). Interacts with CDCP1, TGFB1I1 and TOM1L2 (By similarity). Interacts with DDEF1/ASAP1 via its SH3 domain (PubMed:9819391). Interacts with CCPG1 (PubMed:17000758). Interacts with the cytoplasmic domain of MUC1, phosphorylates it and increases binding of MUC1 with beta-catenin (By similarity). Interacts with RALGPS1 via its SH3 domain (By similarity). Interacts with CAV2 (tyrosine phosphorylated form) (By similarity). Interacts (via the SH3 domain and the protein kinase domain) with ARRB1; the interaction is independent of the phosphorylation state of SRC C-terminus (By similarity). Interacts with FCAMR and PXN (By similarity). Interacts with ARRB2 (PubMed:19122674). Interacts with ARRB1 (By similarity). Interacts with SRCIN1 (By similarity). Interacts with NDFIP2 and more weakly with NDFIP1 (By similarity). Interacts with PIK3CA and/or PIK3C2B, PTK2/FAK1, ESR1 (dimethylated on arginine) and FAK (PubMed:14739300). Interacts (via SH2 and SH3 domain) with TNK2 (By similarity). Interacts (via protein kinase domain) with the tyrosine phosphorylated form of RUNX3 (via runt domain) (By similarity). Interacts with TRAF3 (via RING-type zinc finger domain) (By similarity). Interacts with RIGI, MAVS and TBK1 (By similarity). Interacts (via SH2 domain) with RACK1; the interaction is enhanced by tyrosine phosphorylation of RACK1 and inhibits SRC activity (By similarity). Interacts (via SH2 domain) with the 'Tyr-402' phosphorylated form of PTK2B/PYK2 (PubMed:14739300). Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated) (PubMed:16684964). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (PubMed:11433297). Interacts with EPHB1; activates the MAPK/ERK cascade to regulate cell migration (PubMed:12925710). Interacts with ERBB2 and STAT1 (PubMed:7542762, PubMed:9344858). Interacts with PDGFRA (tyrosine phosphorylated) (PubMed:14644164). Interacts with CSF1R (PubMed:7681396). Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1 (By similarity). Interacts with DDR2 (By similarity). Interacts with AMOTL2; this interaction regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites (By similarity). Interacts with DDR1 and DAB2 (PubMed:20093046). Interacts with TRAP1 (By similarity). Interacts with CBLC; the interaction is enhanced when SRC is phosphorylated at 'Tyr-424' (By similarity). Interacts with ARHGEF5 (PubMed:21525037). Interacts (via cytoplasmic domain) with CEACAM1 (via SH2 domain); this interaction is regulated by trans-homophilic cell adhesion (By similarity). Interacts with MPP2 (By similarity). Interacts with PRR7 (By similarity). Interacts (via kinase domain and to a lesser extent the SH2 domain) directly with PDLIM4; this interaction results in PTPN13-mediated dephosphorylation of this protein leading to its inactivation (By similarity). Interacts with P85 (PIK3R1 or PIK3R2) (By similarity). Interacts with HNRNPA2B1 (PubMed:31320558). Interacts with IL6ST/gp130 (By similarity). Interacts (via SH3 domain) with PELP1 in the presence of 17-beta- estradiol (By similarity). Interacts with AMBRA1 (PubMed:28362576). P05480; P31750: Akt1; NbExp=3; IntAct=EBI-298680, EBI-298707; P05480; P07141: Csf1; NbExp=2; IntAct=EBI-298680, EBI-777188; P05480; P54763: Ephb2; NbExp=3; IntAct=EBI-298680, EBI-537711; P05480; P23242: Gja1; NbExp=3; IntAct=EBI-298680, EBI-298630; P05480; P18052: Ptpra; NbExp=2; IntAct=EBI-298680, EBI-6597520; P05480; P70315: Was; NbExp=2; IntAct=EBI-298680, EBI-644195; P05480; P31016: Dlg4; Xeno; NbExp=9; IntAct=EBI-298680, EBI-375655; P05480; Q8T4F7: ena; Xeno; NbExp=2; IntAct=EBI-298680, EBI-466810; P05480; Q00959: Grin2a; Xeno; NbExp=4; IntAct=EBI-298680, EBI-630970; P05480; P19367: HK1; Xeno; NbExp=8; IntAct=EBI-298680, EBI-713162; P05480; P52789: HK2; Xeno; NbExp=4; IntAct=EBI-298680, EBI-741469; P05480; Q05397: PTK2; Xeno; NbExp=5; IntAct=EBI-298680, EBI-702142; P05480; Q01973: ROR1; Xeno; NbExp=2; IntAct=EBI-298680, EBI-6082337; P05480; Q13507-3: TRPC3; Xeno; NbExp=4; IntAct=EBI-298680, EBI-15563545; P05480-2; P05106: ITGB3; Xeno; NbExp=4; IntAct=EBI-26656723, EBI-702847; Cell membrane ipid-anchor Mitochondrion inner membrane Nucleus Cytoplasm, cytoskeleton Cytoplasm, perinuclear region Cell junction, focal adhesion Note=Localizes to focal adhesion sites following integrin engagement (PubMed:22801373). Localization to focal adhesion sites requires myristoylation and the SH3 domain. Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=c-Src ; IsoId=P05480-2; Sequence=Displayed; Name=2; Synonyms=N1-Src ; IsoId=P05480-1; Sequence=VSP_060883; Myristoylated at Gly-2, and this is essential for targeting to membranes. Dephosphorylated at Tyr-529 by PTPRJ (By similarity). Phosphorylated on Tyr-529 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. Dephosphorylated by PTPRJ at Tyr-418. Normally maintained in an inactive conformation with the SH2 domain engaged with Tyr-529, the SH3 domain engaged with the SH2-kinase linker, and Tyr-418 dephosphorylated. Dephosphorylation of Tyr-529 as a result of protein tyrosine phosphatase (PTP) action disrupts the intramolecular interaction between the SH2 domain and Tyr-529, Tyr-418 can then become autophosphorylated, resulting in SRC activation. Phosphorylation of Tyr-529 by CSK allows this interaction to reform, resulting in SRC inactivation. CDK5-mediated phosphorylation at Ser-74 targets SRC to ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. Phosphorylated by PTK2/FAK1; this enhances kinase activity. Phosphorylated by PTK2B/PYK2; this enhances kinase activity (By similarity). Upon activation of IL6ST by IL6, Tyr-418 is phosphorylated and Tyr-529 dephosphorylated (PubMed:25731159). [Isoform 1]: Displays reduced levels of autophosphorylation at Tyr-418 compared to isoform 2. [Isoform 2]: Displays enhanced levels of autophosphorylation at Tyr-418 compared to isoform 1. S-nitrosylation is important for activation of its kinase activity. Ubiquitinated in response to CDK5-mediated phosphorylation. Ubiquitination mediated by CBLC requires SRC autophosphorylation at Tyr-418 and may lead to lysosomal degradation (By similarity). Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. nucleotide binding primary ovarian follicle growth podosome immune system process protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein kinase C binding receptor binding insulin receptor binding integrin binding protein binding ATP binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial inner membrane lysosome late endosome cytosol cytoskeleton actin filament plasma membrane caveola protein phosphorylation cell cycle cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway protein C-terminus binding cell proliferation response to mechanical stimulus response to virus response to acidic pH positive regulation of gene expression regulation of epithelial cell migration positive regulation of epithelial cell migration positive regulation of platelet-derived growth factor receptor signaling pathway positive regulation of glucose metabolic process positive regulation of protein processing postsynaptic density positive regulation of smooth muscle cell migration membrane kinase activity phosphorylation cell migration transferase activity peptidyl-serine phosphorylation peptidyl-tyrosine phosphorylation enzyme binding kinase binding protein kinase binding protein domain specific binding heme binding regulation of cell-cell adhesion cell differentiation estrogen receptor binding forebrain development extrinsic component of cytoplasmic side of plasma membrane ubiquitin protein ligase binding protein destabilization response to nutrient levels positive regulation of protein autophosphorylation activation of protein kinase B activity negative regulation of telomere maintenance via telomerase negative regulation of protein homooligomerization ruffle membrane cellular response to insulin stimulus regulation of intracellular estrogen receptor signaling pathway adherens junction organization substrate adhesion-dependent cell spreading cellular response to reactive oxygen species positive regulation of dephosphorylation intracellular signal transduction osteoclast development cellular response to platelet-derived growth factor stimulus peptidyl-tyrosine autophosphorylation regulation of cell proliferation SH2 domain binding odontogenesis response to drug response to hydrogen peroxide neuron projection positive regulation of apoptotic process negative regulation of apoptotic process stress fiber assembly negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of protein binding positive regulation of MAP kinase activity positive regulation of phosphatidylinositol 3-kinase activity ion channel binding macromolecular complex binding transcytosis bone resorption positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of cell adhesion negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of insulin receptor signaling pathway protein autophosphorylation ephrin receptor binding neurotrophin TRK receptor signaling pathway perinuclear region of cytoplasm oogenesis positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation cell adhesion molecule binding progesterone receptor signaling pathway positive regulation of small GTPase mediated signal transduction phosphoprotein binding positive regulation of protein transport response to mineralocorticoid response to electrical stimulus negative regulation of focal adhesion assembly positive regulation of protein kinase B signaling negative regulation of mitochondrial depolarization negative regulation of telomerase activity uterus development branching involved in mammary gland duct morphogenesis regulation of cell projection assembly cellular response to hydrogen peroxide positive regulation of ERK1 and ERK2 cascade response to fatty acid response to interleukin-1 BMP receptor binding growth factor receptor binding cellular response to lipopolysaccharide connexin binding cellular response to peptide hormone stimulus cellular response to progesterone stimulus cellular response to fatty acid cellular response to hypoxia cellular response to fluid shear stress cellular response to transforming growth factor beta stimulus positive regulation of podosome assembly positive regulation of protein serine/threonine kinase activity angiotensin-activated signaling pathway involved in heart process positive regulation of canonical Wnt signaling pathway scaffold protein binding cell-cell adhesion regulation of postsynaptic neurotransmitter receptor activity glutamatergic synapse postsynaptic specialization, intracellular component positive regulation of protein localization to nucleus positive regulation of intracellular signal transduction positive regulation of ovarian follicle development positive regulation of lamellipodium morphogenesis positive regulation of DNA biosynthetic process positive regulation of platelet-derived growth factor receptor-beta signaling pathway regulation of early endosome to late endosome transport negative regulation of anoikis negative regulation of extrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway regulation of caveolin-mediated endocytosis uc290cbf.1 uc290cbf.2 
ENSMUST00000109535.3 Tnfrsf13c ENSMUST00000109535.3 Tnfrsf13c (from geneSymbol) AK156387 ENSMUST00000109535.1 ENSMUST00000109535.2 Q3U106 Q3U106_MOUSE Tnfrsf13c uc007wyl.1 uc007wyl.2 membrane integral component of membrane uc007wyl.1 uc007wyl.2 
ENSMUST00000109541.4 Atp6ap1l ENSMUST00000109541.4 ATPase, H+ transporting, lysosomal accessory protein 1-like (from RefSeq NM_001145879.1) Atp6ap1l D3Z5W0 D3Z5W0_MOUSE ENSMUST00000109541.1 ENSMUST00000109541.2 ENSMUST00000109541.3 NM_001145879 uc011zcl.1 uc011zcl.2 uc011zcl.3 Belongs to the vacuolar ATPase subunit S1 family. molecular_function membrane integral component of membrane regulation of cellular pH proton-transporting V-type ATPase, V1 domain plasma membrane proton-transporting V-type ATPase complex proton-transporting ATP synthase activity, rotational mechanism proton-transporting ATPase activity, rotational mechanism hydrogen ion transmembrane transport uc011zcl.1 uc011zcl.2 uc011zcl.3 
ENSMUST00000109543.9 Vcan ENSMUST00000109543.9 versican, transcript variant 4 (from RefSeq NM_001134475.1) E9QMK3 E9QMK3_MOUSE ENSMUST00000109543.1 ENSMUST00000109543.2 ENSMUST00000109543.3 ENSMUST00000109543.4 ENSMUST00000109543.5 ENSMUST00000109543.6 ENSMUST00000109543.7 ENSMUST00000109543.8 NM_001134475 Vcan uc007rjh.1 uc007rjh.2 uc007rjh.3 Belongs to the aggrecan/versican proteoglycan family. Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding hyaluronic acid binding cell adhesion uc007rjh.1 uc007rjh.2 uc007rjh.3 
ENSMUST00000109552.3 Rasa1 ENSMUST00000109552.3 RAS p21 protein activator 1, transcript variant 5 (from RefSeq NR_189748.1) E9PYG6 E9PYG6_MOUSE ENSMUST00000109552.1 ENSMUST00000109552.2 NR_189748 Rasa1 uc007rix.1 uc007rix.2 uc007rix.3 uc007rix.4 ruffle phosphotyrosine binding positive regulation of protein phosphorylation negative regulation of cell-matrix adhesion GTPase activator activity receptor binding platelet-derived growth factor receptor binding protein binding cytosol plasma membrane negative regulation of cell adhesion signal transduction transcription factor binding membrane kinase binding regulation of actin filament polymerization receptor tyrosine kinase binding nuclear membrane cellular response to platelet-derived growth factor stimulus response to drug negative regulation of apoptotic process regulation of GTPase activity protein kinase B binding positive regulation of GTPase activity ion channel binding macromolecular complex binding positive regulation of glucose import negative regulation of Ras protein signal transduction positive regulation of fibroblast proliferation blood vessel morphogenesis positive regulation of peptidyl-tyrosine phosphorylation GTPase binding cellular response to epidermal growth factor stimulus activation of GTPase activity protein tyrosine kinase binding uc007rix.1 uc007rix.2 uc007rix.3 uc007rix.4 
ENSMUST00000109554.3 Zc3h7b ENSMUST00000109554.3 zinc finger CCCH type containing 7B (from RefSeq NM_001081016.2) ENSMUST00000109554.1 ENSMUST00000109554.2 F8VPP8 F8VPP8_MOUSE NM_001081016 Zc3h7b uc007wxe.1 uc007wxe.2 uc007wxe.3 cellular_component posttranscriptional regulation of gene expression production of miRNAs involved in gene silencing by miRNA miRNA binding metal ion binding uc007wxe.1 uc007wxe.2 uc007wxe.3 
ENSMUST00000109556.9 Ogfod1 ENSMUST00000109556.9 2-oxoglutarate and iron-dependent oxygenase domain containing 1, transcript variant 1 (from RefSeq NM_177767.4) ENSMUST00000109556.1 ENSMUST00000109556.2 ENSMUST00000109556.3 ENSMUST00000109556.4 ENSMUST00000109556.5 ENSMUST00000109556.6 ENSMUST00000109556.7 ENSMUST00000109556.8 Kiaa1612 NM_177767 OGFD1_MOUSE Q3TLS5 Q3TPR4 Q3U0K8 Q80TB3 Q8CFR6 uc009mvq.1 uc009mvq.2 uc009mvq.3 Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro- 62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation. Reaction=2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate; Xref=Rhea:RHEA:54156, Rhea:RHEA-COMP:13816, Rhea:RHEA-COMP:13818, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50342, ChEBI:CHEBI:85428; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Monomer. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U0K8-1; Sequence=Displayed; Name=2; IsoId=Q3U0K8-2; Sequence=VSP_025854; Name=3; IsoId=Q3U0K8-3; Sequence=VSP_025853; Belongs to the TPA1 family. Contains Thr-228 instead of the expected predicted active site Lys. Sequence=AAH40267.1; Type=Erroneous initiation; Evidence=; iron ion binding nucleus cytoplasm cytosol regulation of translational termination cell proliferation cytoplasmic stress granule oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors protein hydroxylation peptidyl-proline hydroxylation L-ascorbic acid binding peptidyl-proline dioxygenase activity peptidyl-proline 3-dioxygenase activity stress granule assembly metal ion binding dioxygenase activity oxidation-reduction process uc009mvq.1 uc009mvq.2 uc009mvq.3 
ENSMUST00000109579.9 Mrtfa ENSMUST00000109579.9 myocardin related transcription factor A, transcript variant 1 (from RefSeq NM_153049.3) Bsac ENSMUST00000109579.1 ENSMUST00000109579.2 ENSMUST00000109579.3 ENSMUST00000109579.4 ENSMUST00000109579.5 ENSMUST00000109579.6 ENSMUST00000109579.7 ENSMUST00000109579.8 MRTFA_MOUSE Mal Mkl1 NM_153049 Q642U1 Q8K4J6 uc007wwc.1 uc007wwc.2 uc007wwc.3 uc007wwc.4 Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12019265, PubMed:12732141, PubMed:17588931, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G- actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex (PubMed:12732141, PubMed:17588931). Activity is also regulated by filamentous actin (F-actin) in the nucleus (PubMed:23558171, PubMed:25759381). Interacts with SRF, forming the SRF-MRTFA nuclear complex which binds the 5'-CArG-3' consensus motif (CArG box) on DNA via SRF (PubMed:12732141, PubMed:19350017). Interacts (via RPEL repeats) with globular actin (G-actin), thereby regulating its subcellular location and activity of the complex formed with SRF (PubMed:12732141, PubMed:17588931, PubMed:19350017, PubMed:19008859, PubMed:27304076, PubMed:21673315). Either forms a trivalent (by binding three G-actin monomers) or pentavalent (by binding five G-actin monomers) complex with G-actin (PubMed:21673315). Forms a nuclear ternary complex with SCAI and SRF, leading to suppress MRTFA-induced SRF transcriptional activity (PubMed:19350017). Interacts with beta-actin (ACTB); interaction with ACTB prevents interaction with SCAI (PubMed:19350017). Interacts with MRTFB (By similarity). Q8K4J6; P68135: ACTA1; Xeno; NbExp=15; IntAct=EBI-8291665, EBI-367540; Q8K4J6; P60709: ACTB; Xeno; NbExp=3; IntAct=EBI-8291665, EBI-353944; Q8K4J6; O00629: KPNA4; Xeno; NbExp=4; IntAct=EBI-8291665, EBI-396343; Q8K4J6; Q14974: KPNB1; Xeno; NbExp=2; IntAct=EBI-8291665, EBI-286758; Cytoplasm cleus Note=Subcellular location is tightly regulated by actin both in cytoplasm and nucleus: high levels of G-actin in the nucleus observed during serum deprivation lead to low levels of nuclear MRTFA, while reduced levels of nuclear G-actin result in accumulation of MRTFA in the nucleus (PubMed:17588931, PubMed:21673315). G-actin-binding in the cytoplasm inhibits nuclear import by masking the nuclear localization signal (NLS) (PubMed:17588931, PubMed:21673315). In contrast, binding to nuclear globular actin (G-actin) promotes nuclear export to the cytoplasm (PubMed:17588931). Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear actin, which decreases nuclear G-actin pool, thereby promoting retention of MRTFA in the nucleus and subsequent formation of an active complex with SRF (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K4J6-1; Sequence=Displayed; Name=2; IsoId=Q8K4J6-2; Sequence=VSP_007652; Expressed in heart, brain, spleen, lung, liver, muscle, kidney and testis. Detected throughout the embryo at 10.5 dpc; higher expression is found at 13.5 dpc in neural mesenchymal cells, skeletal muscle of the tongue, and epithelial cells of the colon and small intestine; at 15.5 dpc, expression in epithelial cells of lung, kidney, bladder, and colon is also detected. The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity. The RPEL repeats mediate binding to globular actin (G-actin); each RPEL repeat-binding to one G-actin monomer (PubMed:19008859, PubMed:21673315). In addition, each intervening spacer sequence region can bind one G-actin monomer, to reach a pentavalent complex (PubMed:21673315). Phosphorylation at Ser-41 by Erk inhibits binding of globular actin (G-actin), unmasking the nuclear localization signal (NLS) and promoting nuclear import. Some publications use a protein sequence that is longer at the N-terminus and is based on an artificial construct (PubMed:12732141, PubMed:27304076). The sequence used in these publications modifies a non-canonical CTG leucine codon upstream of the initiator codon into ATG, generating a protein of 1021 residues (PubMed:12732141, PubMed:27304076). The existence of this form has not been confirmed in vivo and is therefore unsure (PubMed:12732141, PubMed:27304076). Similarly, the existence of the S33 ('Ser-33') phosphorylation site described in Panayiotou et al. is unsure (PubMed:27304076). transcription regulatory region sequence-specific DNA binding neuron migration transcription factor activity, sequence-specific DNA binding transcription coactivator activity actin binding actin monomer binding protein binding nucleus nucleoplasm cytoplasm cytosol regulation of transcription from RNA polymerase II promoter positive regulation of transcription via serum response element binding actin cytoskeleton organization forebrain development neuron projection development negative regulation of cysteine-type endopeptidase activity involved in apoptotic process leucine zipper domain binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation negative regulation of apoptotic signaling pathway uc007wwc.1 uc007wwc.2 uc007wwc.3 uc007wwc.4 
ENSMUST00000109582.3 Ces1b ENSMUST00000109582.3 carboxylesterase 1B, transcript variant 2 (from RefSeq NM_001381922.1) Ces1b D3Z5G7 D3Z5G7_MOUSE ENSMUST00000109582.1 ENSMUST00000109582.2 NM_001381922 uc009muk.1 uc009muk.2 uc009muk.3 Belongs to the type-B carboxylesterase/lipase family. sterol esterase activity triglyceride lipase activity extracellular space lipid catabolic process hydrolase activity carboxylic ester hydrolase activity uc009muk.1 uc009muk.2 uc009muk.3 
ENSMUST00000109594.8 Slc1a4 ENSMUST00000109594.8 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (from RefSeq NM_018861.3) ENSMUST00000109594.1 ENSMUST00000109594.2 ENSMUST00000109594.3 ENSMUST00000109594.4 ENSMUST00000109594.5 ENSMUST00000109594.6 ENSMUST00000109594.7 NM_018861 Q3UTP8 Q3UTP8_MOUSE Slc1a4 uc007idb.1 uc007idb.2 uc007idb.3 Membrane ulti-pass membrane protein Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. chloride channel activity centrosome microtubule organizing center L-alanine transmembrane transporter activity L-cystine transmembrane transporter activity L-proline transmembrane transporter activity L-serine transmembrane transporter activity L-threonine transmembrane transporter activity symporter activity L-alanine transport L-cystine transport proline transport L-serine transport threonine transport membrane integral component of membrane dendrite hydroxyproline transport L-hydroxyproline transmembrane transporter activity proline transmembrane transport neuronal cell body cognition transmembrane transport chloride transmembrane transport uc007idb.1 uc007idb.2 uc007idb.3 
ENSMUST00000109604.9 Rbm12 ENSMUST00000109604.9 RNA binding motif protein 12, transcript variant 2 (from RefSeq NM_170598.3) B6ICZ5 ENSMUST00000109604.1 ENSMUST00000109604.2 ENSMUST00000109604.3 ENSMUST00000109604.4 ENSMUST00000109604.5 ENSMUST00000109604.6 ENSMUST00000109604.7 ENSMUST00000109604.8 NM_170598 Q3TKT7 Q7TT14 Q8K373 Q8R302 Q8R4X3 Q9CS80 RBM12_MOUSE uc008nmi.1 uc008nmi.2 uc008nmi.3 This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 2 H2. Two alternatively spliced transcript variants have been identified for this gene. Both variants encode the same protein. [provided by RefSeq, Jul 2008]. Nucleus Sequence=AAH27810.2; Type=Erroneous initiation; Evidence=; nucleic acid binding RNA binding nucleus nucleoplasm biological_process uc008nmi.1 uc008nmi.2 uc008nmi.3 
ENSMUST00000109605.5 Atf4 ENSMUST00000109605.5 activating transcription factor 4, transcript variant 1 (from RefSeq NM_009716.3) ATF4_MOUSE Atf4 Creb2 ENSMUST00000109605.1 ENSMUST00000109605.2 ENSMUST00000109605.3 ENSMUST00000109605.4 NM_009716 Q06507 Q5U4B2 Q61906 uc007wvl.1 uc007wvl.2 uc007wvl.3 uc007wvl.4 Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (PubMed:8506317, PubMed:11106749, PubMed:12667446, PubMed:23624402). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (PubMed:8506317, PubMed:23624402). Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress (PubMed:11106749, PubMed:12667446). During ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (PubMed:11106749, PubMed:12667446). Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (PubMed:12667446). Activates the transcription of NLRP1, possibly in concert with other factors in response to ER stress (By similarity). Activates the transcription of asparagine synthetase (ASNS) in response to amino acid deprivation or ER stress (PubMed:15775988, PubMed:21159964). However, when associated with DDIT3/CHOP, the transcriptional activation of the ASNS gene is inhibited in response to amino acid deprivation (By similarity). Together with DDIT3/CHOP, mediates programmed cell death by promoting the expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the terminal unfolded protein response (terminal UPR), a cellular response that elicits programmed cell death when ER stress is prolonged and unresolved (PubMed:23624402). Together with DDIT3/CHOP, activates the transcription of the IRS-regulator TRIB3 and promotes ER stress-induced neuronal cell death by regulating the expression of BBC3/PUMA in response to ER stress (PubMed:15775988, PubMed:17369260, PubMed:21159964). May cooperate with the UPR transcriptional regulator QRICH1 to regulate ER protein homeostasis which is critical for cell viability in response to ER stress (By similarity). In the absence of stress, ATF4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (PubMed:10096021, PubMed:10885750, PubMed:11806972, PubMed:12925279, PubMed:15109498, PubMed:22298775). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (PubMed:15109498). Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (PubMed:22298775). Activates transcription of SIRT4 (PubMed:23663782). Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4 (PubMed:21768648, PubMed:22572884). Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes (PubMed:21768648, PubMed:22572884). Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (PubMed:12925279). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471). Binds DNA as a homodimer and as a heterodimer (PubMed:23624402). Heterodimer; heterodimerizes with CEBPB (PubMed:11018027). Heterodimer; heterodimerizes with DDIT3/CHOP (PubMed:23624402). Interacts with CEP290 (via an N-terminal region) (By similarity). Interacts with NEK6, DAPK2 (isoform 2) and ZIPK/DAPK3 (By similarity). Interacts (via its leucine zipper domain) with GABBR1 and GABBR2 (via their C-termini) (By similarity). Forms a heterodimer with TXLNG in osteoblasts (PubMed:15911876). Interacts (via its DNA binding domain) with FOXO1 (C-terminal half); the interaction occurs in osteoblasts and regulates glucose homeostasis through suppression of beta-cell proliferation and a decrease in insulin production (PubMed:22298775). Interacts with SATB2; the interaction results in enhanced DNA binding and transactivation by these transcription factors (PubMed:16751105). Interacts with ABRAXAS2 (PubMed:22974638). Interacts with TRIB3, inhibiting the transactivation activity of ATF4 (PubMed:17369260). Interacts with DISC1; which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA- binding (PubMed:31444471). Interacts with EP300/p300; EP300/p300 stabilizes ATF4 and increases its transcriptional activity independently of its catalytic activity by preventing its ubiquitination (By similarity). Q06507; O54784: Dapk3; NbExp=3; IntAct=EBI-77383, EBI-77359; Q06507; P35639: Ddit3; NbExp=3; IntAct=EBI-77383, EBI-10636142; Q06507; Q8K4K2: Trib3; NbExp=3; IntAct=EBI-77383, EBI-448962; Nucleus cleus speckle Cytoplasm Cell membrane Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. Colocalizes with NEK6 in the centrosome (By similarity). Recruited to nuclear speckles following interaction with EP300/p300 (By similarity). Ubiquitously expressed in adults. During embryonic development, expressed at high levels in anterior epithelial lens cells at 14.5 dpc (PubMed:10885750). At 16.5 dpc, expressed in osteoblasts surrounding newly formed trabecular bone (PubMed:19232401). At postnatal day 2, detected in most osteoblasts and lining cells (PubMed:19232401). By postnatal week 4, is detected in fewer osteoblasts, but remains present in lining cells (at protein level) (PubMed:19232401). Regulated at the translational level in response to various stress such as endoplasmic reticulum stress, amino acid starvation or oxidative stress (PubMed:11106749, PubMed:12667446, PubMed:15277680, PubMed:21159964). In the absence of stress, ribosomes re-initiate translation at an inhibitory open reading frame (uORF) upstream of the ATF4 transcript, which precludes AFT4 translation (PubMed:11106749, PubMed:15277680). In response to stress and subsequent EIF2S1/eIF-2- alpha phosphorylation, ribosomes bypass the inhibitory uORF and re- initiate translation at the AFT4 coding sequence (PubMed:15277680). Expressed in a circadian manner in the midbrain with an increased expression seen during the dark phase (at protein level) (PubMed:21768648, PubMed:22572884). Expressed in a circadian manner also in the suprachiasmatic nucleus (SCN) of the brain, cerebral cortex, kidney and small intestine (PubMed:21768648, PubMed:22572884). The BetaTrCP degron motif promotes binding to BTRC when phosphorylated. Ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4 (PubMed:23663782). Interaction with EP300/p300 inhibits ubiquitination by SCF(BTRC) (By similarity). Phosphorylation at Ser-251 by RPS6KA3/RSK2 in osteoblasts enhances transactivation activity and promotes osteoblast differentiation (PubMed:15109498). Phosphorylated on the betaTrCP degron motif at Ser- 218, followed by phosphorylation at Thr-212, Ser-223, Ser-230, Ser-234 and Ser-247, promoting interaction with BTRC and ubiquitination (PubMed:23663782). Phosphorylation is promoted by mTORC1 (PubMed:23663782). Phosphorylation at Ser-214 by CK2 decreases its stability (By similarity). Phosphorylated by NEK6 (By similarity). Hydroxylated by PHD3, leading to decreased protein stability. Mice were born at a much lower rate than predicted by the Mendelian ratio (PubMed:10096021, PubMed:10885750). Homozygous pups generally die during the first hour after birth, although excess mortality occurrs throughout the first 3 weeks of life (PubMed:10096021, PubMed:11806972). Embryos are severely anemic during fetal development, due to an impairment in definitive hematopoiesis (PubMed:11806972). Surviving mice display defects in embryonic lens formation leading to severe microphthalmia in adults (PubMed:10096021, PubMed:10885750). Embryos show delayed bone formation and surviving mice display low bone mass throughout postnatal life (PubMed:15109498). Surviving null mice exhibit an increase in serum insulin levels and low blood glucose levels (PubMed:22298775). There is a decrease in total fat content, gonadal fat, lean mass and body weight (PubMed:22298775). Serum levels of osteocalcin/BGLAP are decreased (PubMed:22298775). PBK/AKT1-mediated phosphorylation of FOXO1 at 'Ser-258' is increased with a subsequent decrease of FOXO1-mediated transcriptional activity (PubMed:22298775). Belongs to the bZIP family. Sequence=AAA53043.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm centrosome microtubule organizing center cytoskeleton plasma membrane gluconeogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cellular calcium ion homeostasis gamma-aminobutyric acid signaling pathway circadian rhythm protein C-terminus binding transcription factor binding response to toxic substance positive regulation of vascular endothelial growth factor production positive regulation of gene expression membrane protein kinase binding neuron differentiation dendrite membrane circadian regulation of gene expression macromolecular complex cellular response to amino acid starvation nuclear periphery response to endoplasmic reticulum stress positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress PERK-mediated unfolded protein response cellular response to glucose starvation mRNA transcription from RNA polymerase II promoter neuron projection negative regulation of potassium ion transport leucine zipper domain binding positive regulation of neuron apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase I promoter positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity rhythmic process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of biomineral tissue development RNA polymerase II transcription factor complex cellular response to oxygen-glucose deprivation negative regulation of oxidative stress-induced neuron death cellular response to dopamine positive regulation of vascular associated smooth muscle cell apoptotic process Lewy body core positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ATF4-CREB1 transcription factor complex ATF1-ATF4 transcription factor complex CHOP-ATF4 complex response to manganese-induced endoplasmic reticulum stress positive regulation of sodium-dependent phosphate transport uc007wvl.1 uc007wvl.2 uc007wvl.3 uc007wvl.4 
ENSMUST00000109608.9 Cpne1 ENSMUST00000109608.9 copine I, transcript variant 1 (from RefSeq NM_170588.4) CPNE1_MOUSE Cpne1 ENSMUST00000109608.1 ENSMUST00000109608.2 ENSMUST00000109608.3 ENSMUST00000109608.4 ENSMUST00000109608.5 ENSMUST00000109608.6 ENSMUST00000109608.7 ENSMUST00000109608.8 NM_170588 Q8C166 Q925K4 Q925K5 uc008nmf.1 uc008nmf.2 uc008nmf.3 uc008nmf.4 This gene encodes a protein that contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Its activity is also upregulated in mouse embryos. This gene and the gene for RNA binding motif protein 12 overlap at map location 2 H2. Two alternatively spliced variants that encode the same isoform have been identified for this gene. [provided by RefSeq, Jul 2008]. Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF- alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium- dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Homodimer; homodimerizes via its C2 domains. Interacts with p65/RELA (via N-terminus); this interaction induces proteolytic cleavage of p65/RELA subunit and inhibition of NF-kappa-B transcriptional activity. Interacts (via VWFA domain) with ACTB, CCDC22, MYCBP2, PPP5C, RDX and UBE2O. Nucleus Cytoplasm Cell membrane Note=Translocates to the cell membrane in a calcium-dependent manner. C2 domains are necessary for calcium-dependent cell membrane association. C2 domains are necessary for neuronal progenitor cell differentiation in a calcium-independent manner. Belongs to the copine family. phosphatidylserine binding endopeptidase activity calcium ion binding protein binding calcium-dependent phospholipid binding nucleus nucleoplasm cytoplasm cytosol plasma membrane proteolysis negative regulation of gene expression membrane cell differentiation nuclear membrane protein homodimerization activity regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of DNA binding positive regulation of neuron differentiation NF-kappaB binding positive regulation of protein kinase B signaling cellular response to calcium ion negative regulation of NIK/NF-kappaB signaling positive regulation of tumor necrosis factor-mediated signaling pathway neuron projection extension uc008nmf.1 uc008nmf.2 uc008nmf.3 uc008nmf.4 
ENSMUST00000109611.8 Fer1l4 ENSMUST00000109611.8 fer-1 like family member 4 (from RefSeq NM_001136556.2) ENSMUST00000109611.1 ENSMUST00000109611.2 ENSMUST00000109611.3 ENSMUST00000109611.4 ENSMUST00000109611.5 ENSMUST00000109611.6 ENSMUST00000109611.7 Fer1l4 NM_001136556 Z4YL23 Z4YL23_MOUSE uc012cho.1 uc012cho.2 uc012cho.3 membrane integral component of membrane uc012cho.1 uc012cho.2 uc012cho.3 
ENSMUST00000109621.10 Tox3 ENSMUST00000109621.10 TOX high mobility group box family member 3, transcript variant 1 (from RefSeq NM_172913.4) ENSMUST00000109621.1 ENSMUST00000109621.2 ENSMUST00000109621.3 ENSMUST00000109621.4 ENSMUST00000109621.5 ENSMUST00000109621.6 ENSMUST00000109621.7 ENSMUST00000109621.8 ENSMUST00000109621.9 NM_172913 Q80W03 Q8BIV8 TOX3_MOUSE Tnrc9 uc009msb.1 uc009msb.2 uc009msb.3 uc009msb.4 uc009msb.5 Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen- responsive C3 promoter region (By similarity). Homodimer. Interacts (via HGM box) with CITED1 (via C- terminus); the interaction increases estrogen-response element (ERE)- dependent transcription and protection against cell death. Interacts with CREB1 (phosphorylated form). Interacts with CREB1; the interaction is not depolarization dependent. Interacts with CREBBP (via C-terminus) (By similarity). Q80W03; Q8VHS6: Asb15; NbExp=2; IntAct=EBI-26675915, EBI-26675998; Nucleus the C-terminus is required for calcium responsiveness but not for transactivation activity. The N-terminus is absolutely necessary for transactivation activity. DNA binding chromatin binding nucleus apoptotic process calcium-mediated signaling estrogen response element binding protein homodimerization activity regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of transcription, DNA-templated phosphoprotein binding uc009msb.1 uc009msb.2 uc009msb.3 uc009msb.4 uc009msb.5 
ENSMUST00000109627.8 Cbx6 ENSMUST00000109627.8 chromobox 6 (from RefSeq NM_028763.3) CBX6_MOUSE ENSMUST00000109627.1 ENSMUST00000109627.2 ENSMUST00000109627.3 ENSMUST00000109627.4 ENSMUST00000109627.5 ENSMUST00000109627.6 ENSMUST00000109627.7 NM_028763 Q8BZH5 Q9DBY5 uc007wuo.1 uc007wuo.2 uc007wuo.3 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (By similarity). Recruitment to chromatin might occur in an H3K27me3-independent fashion (PubMed:22226355, PubMed:16537902). May have a PRC1-independent function in embryonic stem cells (PubMed:22226355). Component of a PRC1-like complex. Distinct PRC1-like core complexes are composed of a RING1 subunit (RING1B or RING1A), one of the six PCGF proteins (PCGF1-6), one PHC protein (PHC1-3) and one of the CBX proteins (CBX2, CBX4, CBX6, CBX7 or CBX8). Interacts with PCGF1, PCGF2, PCGF3, BMI1, PCGF5, PCGF6, RING1 and RNF2. May interact with H3C15 and H3C1 (By similarity). Interacts (via chromodomain) with single-stranded RNA (ssRNA) (PubMed:16537902). Nucleus Chromosome Note=Localizes to the inactivated X chromosome in females. Expressed in mouse embryonic stem cells. Ubiquitinated. Ubiquitination regulates the function of the Polycomb group (PcG) multiprotein PRC1-like complex. Deubiquitinated by USP26. negative regulation of transcription from RNA polymerase II promoter heterochromatin single-stranded RNA binding nucleus chromosome chromatin organization PcG protein complex uc007wuo.1 uc007wuo.2 uc007wuo.3 
ENSMUST00000109629.2 Gm15557 ENSMUST00000109629.2 Gm15557 (from geneSymbol) A6PWY0 A6PWY0_MOUSE ENSMUST00000109629.1 Gm15557 uc290btt.1 uc290btt.2 molecular_function cellular_component biological_process uc290btt.1 uc290btt.2 
ENSMUST00000109636.11 Uqcc1 ENSMUST00000109636.11 ubiquinol-cytochrome c reductase complex assembly factor 1, transcript variant 1 (from RefSeq NM_018888.4) A2ARK1 Bfzb ENSMUST00000109636.1 ENSMUST00000109636.10 ENSMUST00000109636.2 ENSMUST00000109636.3 ENSMUST00000109636.4 ENSMUST00000109636.5 ENSMUST00000109636.6 ENSMUST00000109636.7 ENSMUST00000109636.8 ENSMUST00000109636.9 NM_018888 Q3TET9 Q9CRP2 Q9CWU6 Q9JK78 UQCC1_MOUSE Uqcc uc012chf.1 uc012chf.2 uc012chf.3 Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex) (PubMed:35977508). Involved in cytochrome b translation and/or stability (PubMed:35977508). Interacts with UQCC2 (By similarity). Interacts with UQCC3 (PubMed:35977508). Forms a complex, named COMB/coordinator of mitochondrial CYTB biogenesis, composed of UQCC1, UQCC2, UQCC4, UQCC5 and UQCC6; stabilizes nascent cytochrome b/MT-CYB and promotes its membrane insertion (PubMed:35977508). Forms a complex, named COMA, composed of UQCC1, UQCC2 and UQCC4; activates MT-CYB translation (PubMed:35977508). Forms a complex, named COMC, composed of UQCC1, UQCC2; UQCC3 and UQCC4; mediates MT-CYB hemylation and association with the first nuclear-encoded CIII subunit UQCRQ (PubMed:35977508). Mitochondrion inner membrane Cytoplasmic vesicle Note=Cytoplasmic vesicular structures. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CWU6-1; Sequence=Displayed; Name=2; IsoId=Q9CWU6-2; Sequence=VSP_000858, VSP_000859; In the brain it is restricted to the olfactory bulb, the hippocampus, the piriform cortex and the Purkinje cells. Expressed mainly in the developing nervous system from 9.5 dpc onwards. Also detected in the developing eye and the brown fat. Repressed by bFGF; in embryonic stem cells. Belongs to the CBP3 family. Sequence=AAF64519.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB27433.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; molecular_function mitochondrion mitochondrial inner membrane membrane cytoplasmic vesicle mitochondrial respiratory chain complex III assembly positive regulation of mitochondrial translation uc012chf.1 uc012chf.2 uc012chf.3 
ENSMUST00000109643.8 Sec61g ENSMUST00000109643.8 Endoplasmic reticulum membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein (from UniProt Q5SWJ8) AK012644 ENSMUST00000109643.1 ENSMUST00000109643.2 ENSMUST00000109643.3 ENSMUST00000109643.4 ENSMUST00000109643.5 ENSMUST00000109643.6 ENSMUST00000109643.7 Q5SWJ8 Q5SWJ8_MOUSE Sec61g uc287wsl.1 uc287wsl.2 Endoplasmic reticulum membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein Belongs to the SecE/SEC61-gamma family. cell protein targeting intracellular protein transport protein transport P-P-bond-hydrolysis-driven protein transmembrane transporter activity membrane integral component of membrane protein transmembrane transport uc287wsl.1 uc287wsl.2 
ENSMUST00000109645.9 Vstm2a ENSMUST00000109645.9 V-set and transmembrane domain containing 2A, transcript variant 2 (from RefSeq NM_145967.3) ENSMUST00000109645.1 ENSMUST00000109645.2 ENSMUST00000109645.3 ENSMUST00000109645.4 ENSMUST00000109645.5 ENSMUST00000109645.6 ENSMUST00000109645.7 ENSMUST00000109645.8 NM_145967 Q8R0A6 VTM2A_MOUSE Vstm2 Vstm2a uc007ibk.1 uc007ibk.2 uc007ibk.3 uc007ibk.4 Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway. Homodimer. Secreted Note=Secreted by adipose precursor cells (PubMed:28052263). Not detected in the nucleus (By similarity). Expressed in brain. Expressed in neurons. Expressed in adipose precursor cells in epididymal white adipose tissue (at protein level). Strongly expressed in adipose precursor cells. Weakly expressed in adipocytes. Expressed in embryo in subcutaneous white adipose tissue from 16.5 days post coitum (dpc) to 4 days postnatal (P4). Expressed early in pups in visceral epididymal white adipose tissue at 4 days postnatal (P4) and strongly decreases from P7 to P56 (at protein level). Up-regulated is response to high-fat feeding (at protein level) (PubMed:28052263). Up-regulated by the transcription factor PPARG in a BMP4-signaling dependent manner. Up-regulated during adipocyte differentiation. N-glycosylated. N-linked glycosylation on Asn-35 and Asn-175 is critical for secretion but not for preadipocyte cell differentiation activity. Sequence=AAH27127.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; extracellular region positive regulation of gene expression positive regulation of lipid storage integral component of membrane cell differentiation identical protein binding positive regulation of white fat cell proliferation cellular response to BMP stimulus positive regulation of brown fat cell differentiation nucleus uc007ibk.1 uc007ibk.2 uc007ibk.3 uc007ibk.4 
ENSMUST00000109655.9 Zfp423 ENSMUST00000109655.9 zinc finger protein 423, transcript variant 1 (from RefSeq NM_033327.2) B2RSW4 ENSMUST00000109655.1 ENSMUST00000109655.2 ENSMUST00000109655.3 ENSMUST00000109655.4 ENSMUST00000109655.5 ENSMUST00000109655.6 ENSMUST00000109655.7 ENSMUST00000109655.8 Ebfaz Kiaa0760 NM_033327 Nur12 Oaz Q6PCP2 Q6X497 Q80TS5 Q8CIQ1 Q9ESD2 ZN423_MOUSE Znf423 uc009mqv.1 uc009mqv.2 Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. Homodimer (By similarity). Interacts with SMAD1 and SMAD4. Interacts with EBF1 (By similarity). Interacts with PARP1. Interacts with CEP290 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80TS5-1; Sequence=Displayed; Name=2; IsoId=Q80TS5-2; Sequence=VSP_029008; Within the cerebellum, Zfp423 is expressed in both ventricular and external germinal zones. Transiently expressed in newly differentiating olfactory-receptor neurons. During embryogenesis, it is highly expressed at the dorsal neuroepithelium flanking the roof plate. Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and Olf signaling pathways. C2H2-type zinc fingers 14-19 mediate the interaction with SMAD1 and SMAD4, while zinc fingers 28-30 mediate the interaction with EBF1. zinc fingers 2-8 bind the 5'-CCGCCC-3' DNA sequence in concert with EBF1, while zinc fingers 9-13 bind BMP target gene promoters in concert with SMADs (By similarity). Mice are runted and ataxic, the cerebellum is underdeveloped, and the vermis is severely reduced, resulting in diminished proliferation by granule cell precursors in the external germinal layer, especially near the midline, and abnormal differentiation and migration of ventricular zone-derived neurons and Bergmann glia. In the remaining cerebellar structures, the Purkinje cells are poorly developed and mislocalized. Znf423 gene is a frequent target of retroviral integration in murine B-cell lymphomas. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAG17053.1; Type=Erroneous initiation; Evidence=; Sequence=AAH59234.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence=; Sequence=BAC65647.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding protein binding nucleus nucleoplasm Notch signaling pathway multicellular organism development nervous system development cell differentiation positive regulation of BMP signaling pathway protein homodimerization activity sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated metal ion binding protein heterodimerization activity uc009mqv.1 uc009mqv.2 
ENSMUST00000109670.8 Ncoa6 ENSMUST00000109670.8 nuclear receptor coactivator 6, transcript variant 1 (from RefSeq NM_019825.4) ENSMUST00000109670.1 ENSMUST00000109670.2 ENSMUST00000109670.3 ENSMUST00000109670.4 ENSMUST00000109670.5 ENSMUST00000109670.6 ENSMUST00000109670.7 NM_019825 Ncoa6 Q5XJV5 Q5XJV5_MOUSE uc290bqz.1 uc290bqz.2 transcription coactivator activity nucleus nucleoplasm cytosol DNA-templated transcription, initiation cellular response to DNA damage stimulus enzyme binding myeloid cell differentiation ligand-dependent nuclear receptor transcription coactivator activity histone methyltransferase complex intracellular membrane-bounded organelle positive regulation of transcription from RNA polymerase II promoter thyroid hormone receptor binding uc290bqz.1 uc290bqz.2 
ENSMUST00000109678.3 Spmip7 ENSMUST00000109678.3 sperm microtubule inner protein 7, transcript variant 2 (from RefSeq NM_028669.2) ENSMUST00000109678.1 ENSMUST00000109678.2 NM_028669 Pms1 Q5NC83 Q9D5M8 SMIP7_MOUSE Spata48 uc007iaf.1 uc007iaf.2 Essential for normal spermatogenesis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5NC83-1; Sequence=Displayed; Name=2; IsoId=Q5NC83-2; Sequence=VSP_033234; Testis specific. Expressed at the spermatid stage. Undetectable until 20 days post partum (dpp), and becomes detectable only after 22-30 dpp (PubMed:22110678). Expressed after postnatal day 15 and expression gradually increases with age (PubMed:29700843). Mice have smaller testis and show impaired spermatogenesis. molecular_function cellular_component biological_process uc007iaf.1 uc007iaf.2 
ENSMUST00000109682.9 Dynlrb1 ENSMUST00000109682.9 dynein light chain roadblock-type 1, transcript variant 2 (from RefSeq NM_025947.3) A2AVR8 DLRB1_MOUSE Dncl2a Dnlc2a ENSMUST00000109682.1 ENSMUST00000109682.2 ENSMUST00000109682.3 ENSMUST00000109682.4 ENSMUST00000109682.5 ENSMUST00000109682.6 ENSMUST00000109682.7 ENSMUST00000109682.8 NM_025947 O88567 P62627 Q4FZJ8 Q9D812 uc008nkg.1 uc008nkg.2 uc008nkg.3 uc008nkg.4 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non- catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLRB2. Interacts with DYNC1I1 and DYNC1I2. Interacts with RAB6A isoform 1 (GTP-bound); the interaction is direct. Interacts with RAB6A isoform 2 (GDP-bound); the interaction is direct. Interacts with RAB6B (GDP-bound). Cytoplasm, cytoskeleton Belongs to the GAMAD family. motor activity protein binding cytoplasm centrosome cytoskeleton cytoplasmic dynein complex microtubule microtubule-based movement visual behavior dynein complex identical protein binding dynein intermediate chain binding uc008nkg.1 uc008nkg.2 uc008nkg.3 uc008nkg.4 
ENSMUST00000109690.11 Triobp ENSMUST00000109690.11 TRIO and F-actin binding protein, transcript variant 3 (from RefSeq NM_001039156.1) ENSMUST00000109690.1 ENSMUST00000109690.10 ENSMUST00000109690.2 ENSMUST00000109690.3 ENSMUST00000109690.4 ENSMUST00000109690.5 ENSMUST00000109690.6 ENSMUST00000109690.7 ENSMUST00000109690.8 ENSMUST00000109690.9 Kiaa1662 NM_001039156 Q2PZW9 Q2Q402 Q2Q403 Q2Q404 Q6ZPK4 Q8C6T3 Q8CG90 Q99KW3 TARA_MOUSE Tara uc007wry.1 uc007wry.2 This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]. May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F- actin. The localized formation of TRIOBP and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. [Isoform 4]: Plays a pivotal role in the formation of rootlets. [Isoform 5]: Plays a pivotal role in the formation of rootlets. Binds to TRIO and F-actin (By similarity). May also interact with myosin II (By similarity). Interacts with HECTD3 (By similarity). Interacts with PJVK (PubMed:28209736). Isoform 4 forms homodimers (PubMed:31217345). Isoform 4 interacts with ANKRD24; recruiting TRIOBP isoform 4 to stereocilia rootlets (PubMed:35175278). [Isoform 1]: Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-445 and lasts from prophase to anaphase. At telophase, relocalizes to midbody (By similarity). [Isoform 4]: Cell projection, stereocilium Note=Restricted to the lower half of rootlets, immediately below the apical surface of a hair cell within the cuticular plate. [Isoform 5]: Cell projection, stereocilium Note=Detected in the upper half of rootlets embedded in stereocilia cores. Event=Alternative promoter usage, Alternative splicing; Named isoforms=5; Name=3; Synonyms=Triobp-3 ; IsoId=Q99KW3-3; Sequence=Displayed; Name=4; Synonyms=TRIOBP isoform 5, Triobp-5 ; IsoId=Q99KW3-4; Sequence=VSP_017719; Name=5; Synonyms=TRIOBP isoform 4, Triobp-4 ; IsoId=Q99KW3-5; Sequence=VSP_017721; Name=1; Synonyms=TRIOBP-1 , Triobp1; IsoId=Q99KW3-1; Sequence=VSP_017718, VSP_017720; Name=2; IsoId=Q99KW3-2; Sequence=VSP_016762; [Isoform 3]: Expressed in the brain, liver, kidney, retina, and inner ear. [Isoform 4]: Expressed in the whole embryo, brain, kidney, retina, pancreas, and inner ear. [Isoform 5]: Expressed in the kidney, retina, testis, and inner ear. Contains at least 2 actin-binding sites per coiled-coil dimer. [Isoform 1]: Phosphorylation at Thr-445 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation. Phosphorylation at residues Thr-209 and Thr-445 by kinase NEK2A and PLK1 coordinates TERF1 translocation from telomere to spindle pole. Ubiquitinated by HECTD3, leading to its degradation by the proteasome. [Isoform 4]: Deficient mice display dysmorphic rootlets that are abnormally thin in the cuticular plate but have increased widths and lengths within stereocilia cores, and causes progressive deafness. [Isoform 1]: Isoform 1-null mice are embryonic lethal. Deletion of isoform 4 and isoform 5 results in an absence of stereocilia rootlets and mice are profoundly deaf. Stereocilia lacking rootlets initially have a normal appearance and are capable of mecha-notransduction but are fragile. Shortly after the onset of hearing at P16, these floppy stereocilia lacking rootlets fuse together and rapidly degenerate, followed by the death of hair cells. [Isoform 1]: Produced by alternative promoter usage. [Isoform 2]: Produced by alternative splicing of isoform 3. [Isoform 3]: Produced by alternative promoter usage. [Isoform 4]: Produced by alternative splicing of isoform 3. [Isoform 5]: Produced by alternative splicing of isoform 3. Sequence=BAC98227.2; Type=Erroneous initiation; Evidence=; actin binding nucleus cytoplasm microtubule organizing center cytoskeleton cell cycle sensory perception of sound actin cytoskeleton midbody ubiquitin protein ligase binding stereocilium cuticular plate actin filament binding actin filament bundle assembly cell division auditory receptor cell stereocilium organization positive regulation of substrate adhesion-dependent cell spreading uc007wry.1 uc007wry.2 
ENSMUST00000109691.4 Rapgef5 ENSMUST00000109691.4 Rap guanine nucleotide exchange factor (GEF) 5, transcript variant 2 (from RefSeq NM_175930.6) ENSMUST00000109691.1 ENSMUST00000109691.2 ENSMUST00000109691.3 Gfr Kiaa0277 Mrgef NM_175930 Q8BJJ9 Q8C0Q9 Q8C0R5 RPGF5_MOUSE uc007pib.1 uc007pib.2 uc007pib.3 uc007pib.4 Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C0Q9-1; Sequence=Displayed; Name=2; IsoId=Q8C0Q9-2; Sequence=VSP_007617, VSP_007618; Name=3; IsoId=Q8C0Q9-3; Sequence=VSP_007619, VSP_007620; Sequence=BAC65516.1; Type=Erroneous initiation; Evidence=; guanyl-nucleotide exchange factor activity nucleus nucleoplasm small GTPase mediated signal transduction nuclear body Rap guanyl-nucleotide exchange factor activity GTP-dependent protein binding intracellular signal transduction uc007pib.1 uc007pib.2 uc007pib.3 uc007pib.4 
ENSMUST00000109697.8 a ENSMUST00000109697.8 Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth. (from UniProt Q03288) A2ALT3 ASIP_MOUSE Asip ENSMUST00000109697.1 ENSMUST00000109697.2 ENSMUST00000109697.3 ENSMUST00000109697.4 ENSMUST00000109697.5 ENSMUST00000109697.6 ENSMUST00000109697.7 L06941 Q03288 Q80ST0 uc290bpx.1 uc290bpx.2 Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth. Secreted Epithelial cells of the hair follicles and the epidermis. Widely expressed in embryonic and neonatal skin. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. receptor binding protein binding extracellular region cell generation of precursor metabolites and energy adult feeding behavior hormone-mediated signaling pathway melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding melanosome transport melanosome organization regulation of molecular function, epigenetic melanin biosynthetic process pigmentation positive regulation of melanin biosynthetic process genetic imprinting uc290bpx.1 uc290bpx.2 
ENSMUST00000109726.8 Mta1 ENSMUST00000109726.8 metastasis associated 1, transcript variant 11 (from RefSeq NR_186595.1) ENSMUST00000109726.1 ENSMUST00000109726.2 ENSMUST00000109726.3 ENSMUST00000109726.4 ENSMUST00000109726.5 ENSMUST00000109726.6 ENSMUST00000109726.7 F8WHY8 F8WHY8_MOUSE Mta1 NR_186595 uc007pfv.1 uc007pfv.2 DNA binding chromatin binding nucleus regulation of transcription, DNA-templated zinc ion binding sequence-specific DNA binding uc007pfv.1 uc007pfv.2 
ENSMUST00000109728.8 Snta1 ENSMUST00000109728.8 syntrophin, acidic 1 (from RefSeq NM_009228.2) A2AKD7 A2AKD7_MOUSE ENSMUST00000109728.1 ENSMUST00000109728.2 ENSMUST00000109728.3 ENSMUST00000109728.4 ENSMUST00000109728.5 ENSMUST00000109728.6 ENSMUST00000109728.7 NM_009228 Snta1 uc008nje.1 uc008nje.2 uc008nje.3 uc008nje.4 Cytoplasm, cytoskeleton Belongs to the syntrophin family. regulation of heart rate structural molecule activity sodium channel regulator activity PDZ domain binding neuromuscular junction macromolecular complex sarcolemma ion channel binding nitric-oxide synthase binding ATPase binding regulation of ventricular cardiac muscle cell membrane repolarization ventricular cardiac muscle cell action potential negative regulation of peptidyl-cysteine S-nitrosylation regulation of sodium ion transmembrane transport uc008nje.1 uc008nje.2 uc008nje.3 uc008nje.4 
ENSMUST00000109731.8 Cdk5rap1 ENSMUST00000109731.8 Methylthiotransferase that catalyzes the conversion of N6- (dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:25738458). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:25738458). Specifically inhibits CDK5 activation by CDK5R1 (By similarity). Essential for efficient mitochondrial protein synthesis and respiratory chain (PubMed:25738458). (from UniProt Q8BTW8) AK088517 CK5P1_MOUSE Cdk5rap1 ENSMUST00000109731.1 ENSMUST00000109731.2 ENSMUST00000109731.3 ENSMUST00000109731.4 ENSMUST00000109731.5 ENSMUST00000109731.6 ENSMUST00000109731.7 Q8BTW8 Q9D6Q4 uc290boc.1 uc290boc.2 Methylthiotransferase that catalyzes the conversion of N6- (dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:25738458). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:25738458). Specifically inhibits CDK5 activation by CDK5R1 (By similarity). Essential for efficient mitochondrial protein synthesis and respiratory chain (PubMed:25738458). Reaction=[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)- dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:37067, Rhea:RHEA-COMP:10375, Rhea:RHEA-COMP:10376, Rhea:RHEA-COMP:14737, Rhea:RHEA-COMP:14739, ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319, ChEBI:CHEBI:17499, ChEBI:CHEBI:29917, ChEBI:CHEBI:57844, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64428, ChEBI:CHEBI:74415, ChEBI:CHEBI:74417; EC=2.8.4.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37068; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. ; Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Probably forms a complex with CDK5R1 and CDK5. Mitochondrion Expressed in brain, liver, skeletal muscle and heart. Knockout mice show a deficiency in ms(2)i(6)A modification, resulting in impaired mitochondrial protein synthesis, which leads to respiratory defects. Belongs to the methylthiotransferase family. MiaB subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity catalytic activity mitochondrion cytosol tRNA modification transferase activity methylthiotransferase activity N6-isopentenyladenosine methylthiotransferase activity tRNA methylthiolation macromolecular complex binding negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of translational fidelity metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding positive regulation of mitochondrial translation mitochondrial tRNA modification uc290boc.1 uc290boc.2 
ENSMUST00000109732.3 Zfp429 ENSMUST00000109732.3 zinc finger protein 429, transcript variant 7 (from RefSeq NM_001418856.1) AI929863 ENSMUST00000109732.1 ENSMUST00000109732.2 NM_001418856 Q7M6Y0 Q7M6Y0_MOUSE Rsl1 Rsl2 Zfp429 uc007ras.1 uc007ras.2 uc007ras.3 uc007ras.4 uc007ras.5 May be involved in transcriptional regulation. molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc007ras.1 uc007ras.2 uc007ras.3 uc007ras.4 uc007ras.5 
ENSMUST00000109734.8 Prdx2 ENSMUST00000109734.8 peroxiredoxin 2, transcript variant 2 (from RefSeq NM_001317385.1) ENSMUST00000109734.1 ENSMUST00000109734.2 ENSMUST00000109734.3 ENSMUST00000109734.4 ENSMUST00000109734.5 ENSMUST00000109734.6 ENSMUST00000109734.7 NM_001317385 O88376 PRDX2_MOUSE Q60796 Q61171 Q9CWJ4 Q9DB49 Tdpx1 Tpx uc057cch.1 uc057cch.2 uc057cch.3 uc057cch.4 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]- disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.24; Evidence=; Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer (By similarity). Interacts with TIPIN (PubMed:17141802). Cytoplasm Widely expressed with highest levels in bone marrow. High levels also found in heart, brain, kidney and skeletal muscle. Lower levels in liver, lung and thymus. The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner. The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin. Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. activation of MAPK activity respiratory burst involved in inflammatory response peroxidase activity protein binding cytoplasm mitochondrion cytosol response to oxidative stress thioredoxin peroxidase activity selenium binding regulation of hydrogen peroxide metabolic process antioxidant activity oxidoreductase activity removal of superoxide radicals positive regulation of blood coagulation negative regulation of lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity response to lipopolysaccharide cellular response to oxidative stress T cell proliferation hydrogen peroxide metabolic process hydrogen peroxide catabolic process regulation of apoptotic process myelin sheath negative regulation of neuron apoptotic process leukocyte activation cell redox homeostasis negative regulation of T cell differentiation thymus development homeostasis of number of cells peroxiredoxin activity oxidation-reduction process negative regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc057cch.1 uc057cch.2 uc057cch.3 uc057cch.4 
ENSMUST00000109736.9 Rnaseh2a ENSMUST00000109736.9 Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. (from UniProt Q9CWY8) AK146518 ENSMUST00000109736.1 ENSMUST00000109736.2 ENSMUST00000109736.3 ENSMUST00000109736.4 ENSMUST00000109736.5 ENSMUST00000109736.6 ENSMUST00000109736.7 ENSMUST00000109736.8 Q8CHY8 Q9CWY8 RNH2A_MOUSE Rnasehi uc292bqe.1 uc292bqe.2 Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. ; The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C. Nucleus Belongs to the RNase HII family. Eukaryotic subfamily. nucleic acid binding RNA binding nuclease activity endonuclease activity RNA-DNA hybrid ribonuclease activity nucleus nucleoplasm cytosol mismatch repair RNA catabolic process RNA metabolic process hydrolase activity ribonuclease H2 complex DNA replication, removal of RNA primer metal ion binding nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc292bqe.1 uc292bqe.2 
ENSMUST00000109737.9 H2az2 ENSMUST00000109737.9 H2A.Z histone variant 2, transcript variant 1 (from RefSeq NM_029938.1) ENSMUST00000109737.1 ENSMUST00000109737.2 ENSMUST00000109737.3 ENSMUST00000109737.4 ENSMUST00000109737.5 ENSMUST00000109737.6 ENSMUST00000109737.7 ENSMUST00000109737.8 H2AV_MOUSE H2afv H2av H2az2 NM_029938 Q3THW5 Q5NC92 Q6ZWU0 uc007hyp.1 uc007hyp.2 uc007hyp.3 uc007hyp.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ2 forms a heterodimer with H2B (By similarity). Nucleus Chromosome Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression. Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007hyp.1 uc007hyp.2 uc007hyp.3 uc007hyp.4 
ENSMUST00000109740.9 Rtbdn ENSMUST00000109740.9 retbindin, transcript variant 1 (from RefSeq NM_001357326.1) ENSMUST00000109740.1 ENSMUST00000109740.2 ENSMUST00000109740.3 ENSMUST00000109740.4 ENSMUST00000109740.5 ENSMUST00000109740.6 ENSMUST00000109740.7 ENSMUST00000109740.8 NM_001357326 Q6T898 Q8QZY4 RTBDN_MOUSE uc009moh.1 uc009moh.2 Riboflavin-binding protein which might have a role in retinal flavin transport. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix Cell membrane ; Peripheral membrane protein Expressed in the peripheral retina where it localizes to the inter-photoreceptor matrix (at protein level). May be produced by rod photoreceptors (at protein level). Not N-glycosylated. Belongs to the folate receptor family. extracellular region plasma membrane membrane extrinsic component of plasma membrane anchored component of external side of plasma membrane riboflavin transporter activity riboflavin transport interphotoreceptor matrix signaling receptor activity riboflavin binding uc009moh.1 uc009moh.2 
ENSMUST00000109741.9 Mast1 ENSMUST00000109741.9 microtubule associated serine/threonine kinase 1 (from RefSeq NM_019945.2) ENSMUST00000109741.1 ENSMUST00000109741.2 ENSMUST00000109741.3 ENSMUST00000109741.4 ENSMUST00000109741.5 ENSMUST00000109741.6 ENSMUST00000109741.7 ENSMUST00000109741.8 Kiaa0973 MAST1_MOUSE Mast1 NM_019945 Q7TQG9 Q80TN0 Q9R1L5 Sast uc009mof.1 uc009mof.2 uc009mof.3 Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with the microtubules (PubMed:30449657). Part of a low affinity complex that associates with, but is distinct from, the postsynaptic density. Interacts with SNTB2. Q9R1L5; P60484: PTEN; Xeno; NbExp=3; IntAct=EBI-491771, EBI-696162; Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Cell projection, axon Cell projection, dendrite Note=Also localized in the soma of neurons (PubMed:30449657). Observed as punctate clusters in the processes of interneurons and along the cell body periphery. Colocalizes with syntrophins at the cell membrane. Expressed in the brain (PubMed:30449657). Expressed in the developing cortical plate, the intermediate zone and corpus callosal fibers that cross the midline (PubMed:30449657). Detected at low levels in the testis, liver and spleen (PubMed:30449657). Expressed in proximity to neuronal nuclei throughout the cortex and cerebellum, and in the vascular endothelium. Also detected in ependymal cells, the choroid plexus, and in developing spermatid acrosomes. Expression in the brain begins at 12.5 dpc, peaks at 16.5 dpc, and decreases postnatally. Knockout mice do not show morphological defects. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Sequence=AAD50548.1; Type=Frameshift; Evidence=; Sequence=BAC65693.3; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence=; nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm cytoskeleton plasma membrane protein phosphorylation cytoskeleton organization brain development microtubule binding membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation axon dendrite intracellular signal transduction cell projection neuron projection neuronal cell body metal ion binding uc009mof.1 uc009mof.2 uc009mof.3 
ENSMUST00000109742.11 Zfp708 ENSMUST00000109742.11 zinc finger protein 708, transcript variant 2 (from RefSeq NM_001012448.2) ENSMUST00000109742.1 ENSMUST00000109742.10 ENSMUST00000109742.2 ENSMUST00000109742.3 ENSMUST00000109742.4 ENSMUST00000109742.5 ENSMUST00000109742.6 ENSMUST00000109742.7 ENSMUST00000109742.8 ENSMUST00000109742.9 F2Z422 F2Z422_MOUSE NM_001012448 Zfp708 uc007rac.1 uc007rac.2 uc007rac.3 Nucleus nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007rac.1 uc007rac.2 uc007rac.3 
ENSMUST00000109745.8 Gcdh ENSMUST00000109745.8 Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L- hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. (from UniProt Q60759) AK165406 ENSMUST00000109745.1 ENSMUST00000109745.2 ENSMUST00000109745.3 ENSMUST00000109745.4 ENSMUST00000109745.5 ENSMUST00000109745.6 ENSMUST00000109745.7 GCDH_MOUSE Q60759 Q6P8N6 uc292bpn.1 uc292bpn.2 Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L- hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Reaction=glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:13389, Rhea:RHEA-COMP:10685, Rhea:RHEA- COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57332, ChEBI:CHEBI:57378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307; EC=1.3.8.6; Name=FAD; Xref=ChEBI:CHEBI:57692; Amino-acid metabolism; lysine degradation. Amino-acid metabolism; tryptophan metabolism. Homotetramer. Mitochondrion matrix. Animals show highly increased protein glutarylation in liver. Belongs to the acyl-CoA dehydrogenase family. fatty-acyl-CoA binding acyl-CoA dehydrogenase activity glutaryl-CoA dehydrogenase activity mitochondrion mitochondrial inner membrane mitochondrial matrix tryptophan metabolic process acyl-CoA metabolic process oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors fatty acid oxidation fatty acid beta-oxidation using acyl-CoA dehydrogenase glutaryl-CoA hydrolase activity fatty-acyl-CoA biosynthetic process flavin adenine dinucleotide binding oxidation-reduction process uc292bpn.1 uc292bpn.2 
ENSMUST00000109753.3 Bpifa6 ENSMUST00000109753.3 BPI fold containing family A, member 6 (from RefSeq NM_001080811.1) Bpifa6 EG545477 ENSMUST00000109753.1 ENSMUST00000109753.2 Gm5840 NM_001080811 Q0VGU8 Q0VGU8_MOUSE uc008nir.1 uc008nir.2 molecular_function cellular_component biological_process lipid binding uc008nir.1 uc008nir.2 
ENSMUST00000109757.8 Bpifb4 ENSMUST00000109757.8 May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity). (from UniProt A2BGH0) A2BGH0 AK143420 BPIB4_MOUSE ENSMUST00000109757.1 ENSMUST00000109757.2 ENSMUST00000109757.3 ENSMUST00000109757.4 ENSMUST00000109757.5 ENSMUST00000109757.6 ENSMUST00000109757.7 Gm1006 Lplunc4 Q3UPM5 uc290bno.1 uc290bno.2 May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity). Secreted Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2BGH0-1; Sequence=Displayed; Name=2 ; IsoId=A2BGH0-2; Sequence=VSP_052985, VSP_052986; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. cellular_component extracellular region cytoplasm biological_process lipid binding uc290bno.1 uc290bno.2 
ENSMUST00000109764.8 Nfix ENSMUST00000109764.8 nuclear factor I/X, transcript variant 8 (from RefSeq NM_001371055.1) E9PUH7 E9PUH7_MOUSE ENSMUST00000109764.1 ENSMUST00000109764.2 ENSMUST00000109764.3 ENSMUST00000109764.4 ENSMUST00000109764.5 ENSMUST00000109764.6 ENSMUST00000109764.7 NM_001371055 Nfix uc009mnc.1 uc009mnc.2 uc009mnc.3 uc009mnc.4 Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Binds DNA as a homodimer. Nucleus Belongs to the CTF/NF-I family. negative regulation of transcription from RNA polymerase II promoter DNA binding transcription factor activity, sequence-specific DNA binding nucleus DNA replication regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc009mnc.1 uc009mnc.2 uc009mnc.3 uc009mnc.4 
ENSMUST00000109769.10 Cdc14b ENSMUST00000109769.10 CDC14 cell division cycle 14B, transcript variant 2 (from RefSeq NM_001122989.1) CC14B_MOUSE ENSMUST00000109769.1 ENSMUST00000109769.2 ENSMUST00000109769.3 ENSMUST00000109769.4 ENSMUST00000109769.5 ENSMUST00000109769.6 ENSMUST00000109769.7 ENSMUST00000109769.8 ENSMUST00000109769.9 NM_001122989 Q6PFY9 Q80WC4 Q8BLV5 uc007qyo.1 uc007qyo.2 uc007qyo.3 uc007qyo.4 Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Interacts with FZR1/CDH1. Nucleus, nucleolus Nucleus, nucleoplasm Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PFY9-1; Sequence=Displayed; Name=2; IsoId=Q6PFY9-2; Sequence=VSP_012325; Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold. Belongs to the protein-tyrosine phosphatase family. Non- receptor class CDC14 subfamily. microtubule cytoskeleton organization mitotic cell cycle spindle pole phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity nucleus nucleoplasm nucleolus cytoplasm centrosome DNA repair protein dephosphorylation cellular response to DNA damage stimulus regulation of exit from mitosis protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity positive regulation of cytokinesis peptidyl-tyrosine dephosphorylation cilium assembly mitotic cell cycle arrest signal transduction involved in G2 DNA damage checkpoint mitotic spindle positive regulation of ubiquitin protein ligase activity uc007qyo.1 uc007qyo.2 uc007qyo.3 uc007qyo.4 
ENSMUST00000109787.8 Zmiz2 ENSMUST00000109787.8 zinc finger, MIZ-type containing 2, transcript variant 1 (from RefSeq NM_028601.4) D11Bwg0280e ENSMUST00000109787.1 ENSMUST00000109787.2 ENSMUST00000109787.3 ENSMUST00000109787.4 ENSMUST00000109787.5 ENSMUST00000109787.6 ENSMUST00000109787.7 NM_028601 Q5SVX4 Q5SVX5 Q5SVX6 Q6P558 Q6P9Q5 Q8BJ00 Q8CIE2 ZMIZ2_MOUSE Zimp7 uc287wmr.1 uc287wmr.2 Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors. Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription (By similarity). Nucleus Note=Detected at replication foci throughout S phase. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CIE2-1; Sequence=Displayed; Name=2; IsoId=Q8CIE2-2; Sequence=VSP_012191; Name=3; IsoId=Q8CIE2-3; Sequence=VSP_024919; [Isoform 2]: May be due to a competing acceptor splice site. Sequence=BAC33364.1; Type=Erroneous initiation; Evidence=; RNA polymerase II transcription factor binding transcription cofactor activity nucleus nucleoplasm mitochondrion regulation of transcription from RNA polymerase II promoter zinc ion binding protein sumoylation ligand-dependent nuclear receptor transcription coactivator activity nuclear replication fork positive regulation of transcription from RNA polymerase II promoter metal ion binding chromatin-mediated maintenance of transcription SUMO ligase activity uc287wmr.1 uc287wmr.2 
ENSMUST00000109790.2 Asxl1 ENSMUST00000109790.2 ASXL transcriptional regulator 1 (from RefSeq NM_001039939.2) Asxl1 ENSMUST00000109790.1 NM_001039939 Q24JP2 Q24JP2_MOUSE uc033hqy.1 uc033hqy.2 uc033hqy.3 Nucleus Belongs to the Asx family. DNA binding transcription, DNA-templated regulation of transcription, DNA-templated PR-DUB complex monoubiquitinated histone H2A deubiquitination uc033hqy.1 uc033hqy.2 uc033hqy.3 
ENSMUST00000109799.8 Hck ENSMUST00000109799.8 hemopoietic cell kinase, transcript variant 1 (from RefSeq NM_001172117.1) ENSMUST00000109799.1 ENSMUST00000109799.2 ENSMUST00000109799.3 ENSMUST00000109799.4 ENSMUST00000109799.5 ENSMUST00000109799.6 ENSMUST00000109799.7 HCK_MOUSE NM_001172117 P08103 Q0VH03 Q3UD17 uc008nhc.1 uc008nhc.2 uc008nhc.3 uc008nhc.4 The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq, Feb 2010]. Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Subject to autoinhibition, mediated by intramolecular interactions involving the SH2 and SH3 domains. Kinase activity is also regulated by phosphorylation at regulatory tyrosine residues. Phosphorylation at Tyr-409 is required for optimal activity. Phosphorylation at Tyr-520 inhibits kinase activity. Inhibited by PP1. Interacts with ADAM15. Interacts with FASLG. Interacts with ARRB1 and ARRB2. Interacts with FCGR1A; the interaction may be indirect. Interacts with IL6ST. Interacts (via SH3 domain) with ELMO1. Interacts (via SH3 domain) with TP73. Interacts with YAP1. Interacts with ABL1 and ITGB1, and thereby recruits ABL1 to activated ITGB1 (By similarity). Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with CBL. Interacts with VAV1, WAS and RAPGEF1. Interacts (via SH3 domain) with WDCP (By similarity). P08103; P42768: WAS; Xeno; NbExp=3; IntAct=EBI-6248894, EBI-346375; Cytoplasmic vesicle, secretory vesicle Cytoplasm, cytosol [Isoform 1]: Membrane; Lipid-anchor. Membrane, caveola Lysosome Cell projection, podosome membrane ; Lipid-anchor Cytoplasm, cytosol Note=Associated with specialized secretory lysosomes called azurophil granules. A fraction of this isoform is found in the cytoplasm, some of this fraction is myristoylated (By similarity). [Isoform 2]: Cell membrane; Lipid-anchor. Membrane, caveola ; Lipid-anchor Cell junction, focal adhesion Cytoplasm, cytoskeleton Golgi apparatus Cytoplasmic vesicle Lysosome Nucleus Note=20% of this isoform is associated with caveolae. Localization at the cell membrane and at caveolae requires palmitoylation at Cys-3. Colocalizes with the actin cytoskeleton at focal adhesions (By similarity). Event=Alternative initiation; Named isoforms=2; Name=1; Synonyms=p59-HCK; IsoId=P08103-1; Sequence=Displayed; Name=2; Synonyms=p56-HCK; IsoId=P08103-2; Sequence=VSP_018859; Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Phosphorylated on several tyrosine residues. Autophosphorylated. Becomes rapidly phosphorylated upon activation of the immunoglobulin receptors FCGR1A and FCGR2A. Phosphorylation at Tyr-409 increases kinase activity. Phosphorylation at Tyr-520 inhibits kinase activity. Kinase activity is not required for phosphorylation at Tyr-520, suggesting that this site may be a target of other kinases. Ubiquitinated by CBL, leading to its degradation via the proteasome. Isoform 2 palmitoylation at position 2 requires prior myristoylation. Palmitoylation at position 3 is required for caveolar localization of isoform 2. No visible phenotype, but macrophages have impaired phagocytosis. Mice lacking both HCK and FGR are extremely sensitive to infections by L.monocytogenes. [Isoform 1]: Initiates from a CTG codon. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Sequence=AAA37305.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence=; Sequence=BAE29054.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence=; Sequence=BAE29445.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence=; Sequence=BAE29787.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence=; Sequence=BAE33532.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence=; Sequence=BAE38133.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence=; Sequence=CAA68544.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence=; nucleotide binding phosphotyrosine binding immune system process protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding nucleus nucleoplasm cytoplasm lysosome Golgi apparatus cytosol cytoskeleton plasma membrane caveola focal adhesion protein phosphorylation exocytosis phagocytosis inflammatory response transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation regulation of cell shape membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation cell junction transport vesicle cell differentiation extrinsic component of cytoplasmic side of plasma membrane cytoplasmic vesicle peptidyl-tyrosine autophosphorylation regulation of cell proliferation cell projection negative regulation of apoptotic process innate immune response protein autophosphorylation regulation of phagocytosis defense response to Gram-positive bacterium regulation of sequence-specific DNA binding transcription factor activity regulation of podosome assembly positive regulation of actin cytoskeleton reorganization actin filament uc008nhc.1 uc008nhc.2 uc008nhc.3 uc008nhc.4 
ENSMUST00000109813.9 Camk2b ENSMUST00000109813.9 calcium/calmodulin-dependent protein kinase II, beta, transcript variant 2 (from RefSeq NM_007595.6) Camk2d ENSMUST00000109813.1 ENSMUST00000109813.2 ENSMUST00000109813.3 ENSMUST00000109813.4 ENSMUST00000109813.5 ENSMUST00000109813.6 ENSMUST00000109813.7 ENSMUST00000109813.8 KCC2B_MOUSE NM_007595 P28652 Q5SVH9 uc007hxr.1 uc007hxr.2 uc007hxr.3 uc007hxr.4 uc007hxr.5 Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2 (PubMed:21752990). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Thr-134' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17; Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity. CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with SYNGAP1, CAMK2N2 and MPDZ (By similarity). Interacts with FOXO3 (PubMed:23805378). Interacts (when in a kinase inactive state not associated with calmodulin) with ARC; leading to target ARC to inactive synapses (By similarity). Interacts with CAMK2N1; this interaction requires CAMK2B activation by Ca(2+) (By similarity). P28652; Q9WV31: Arc; NbExp=2; IntAct=EBI-397029, EBI-397779; P28652; P11716: RYR1; Xeno; NbExp=4; IntAct=EBI-397029, EBI-6477441; Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Synapse The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization. Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. Impaired long-term potentiation (LTP) and hippocampus-dependent learning. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. G1/S transition of mitotic cell cycle nucleotide binding inhibitory G-protein coupled receptor phosphorylation protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity protein binding calmodulin binding ATP binding cytoplasm microtubule organizing center cytosol cytoskeleton protein phosphorylation calcium ion transport nervous system development positive regulation of neuron projection development postsynaptic density membrane kinase activity phosphorylation sarcoplasmic reticulum transferase activity peptidyl-serine phosphorylation protein kinase binding cell junction cell differentiation dendrite regulation of synaptic transmission, cholinergic positive regulation of phospholipase A2 activity sarcoplasmic reticulum membrane identical protein binding protein homodimerization activity neuron projection perikaryon phospholipase binding synapse response to cadmium ion protein autophosphorylation regulation of long-term neuronal synaptic plasticity cell projection morphogenesis neuromuscular process controlling balance spindle midzone long-term synaptic potentiation activation of meiosis involved in egg activation positive regulation of dendritic spine morphogenesis positive regulation of synapse maturation structural constituent of postsynaptic actin cytoskeleton postsynaptic actin cytoskeleton organization glutamatergic synapse regulation of protein localization to plasma membrane regulation of neuron migration positive regulation of apoptotic signaling pathway uc007hxr.1 uc007hxr.2 uc007hxr.3 uc007hxr.4 uc007hxr.5 
ENSMUST00000109834.3 Defb45 ENSMUST00000109834.3 defensin beta 45 (from RefSeq NM_001037752.2) DEFB27 Defb27 Defb45 ENSMUST00000109834.1 ENSMUST00000109834.2 NM_001037752 OTTMUSG00000015859 Q3V490 Q3V490_MOUSE uc008nft.1 uc008nft.2 uc008nft.3 Has antibacterial activity. Secreted Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium innate immune response uc008nft.1 uc008nft.2 uc008nft.3 
ENSMUST00000109836.3 Defb20 ENSMUST00000109836.3 defensin beta 20 (from RefSeq NM_176950.4) DFB20_MOUSE ENSMUST00000109836.1 ENSMUST00000109836.2 NM_176950 Q30KP3 Q8C5A7 uc008nfm.1 uc008nfm.2 Has antibacterial activity. Secreted Belongs to the beta-defensin family. Sequence=BAC37500.1; Type=Erroneous initiation; Evidence=; molecular_function extracellular region defense response defense response to bacterium innate immune response uc008nfm.1 uc008nfm.2 
ENSMUST00000109848.10 Wars1 ENSMUST00000109848.10 tryptophanyl-tRNA synthetase1, transcript variant 9 (from RefSeq NR_177977.1) ENSMUST00000109848.1 ENSMUST00000109848.2 ENSMUST00000109848.3 ENSMUST00000109848.4 ENSMUST00000109848.5 ENSMUST00000109848.6 ENSMUST00000109848.7 ENSMUST00000109848.8 ENSMUST00000109848.9 NR_177977 Q3U6U7 Q3U6U7_MOUSE Wars Wars1 uc007pai.1 uc007pai.2 uc007pai.3 Reaction=ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L- tryptophanyl-tRNA(Trp); Xref=Rhea:RHEA:24080, Rhea:RHEA-COMP:9671, Rhea:RHEA-COMP:9705, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57912, ChEBI:CHEBI:78442, ChEBI:CHEBI:78535, ChEBI:CHEBI:456215; EC=6.1.1.2; Evidence=; Belongs to the class-I aminoacyl-tRNA synthetase family. nucleotide binding aminoacyl-tRNA ligase activity tryptophan-tRNA ligase activity ATP binding translation tRNA aminoacylation for protein translation tryptophanyl-tRNA aminoacylation ligase activity uc007pai.1 uc007pai.2 uc007pai.3 
ENSMUST00000109854.9 Evl ENSMUST00000109854.9 Ena-vasodilator stimulated phosphoprotein, transcript variant 5 (from RefSeq NM_001422023.1) ENSMUST00000109854.1 ENSMUST00000109854.2 ENSMUST00000109854.3 ENSMUST00000109854.4 ENSMUST00000109854.5 ENSMUST00000109854.6 ENSMUST00000109854.7 ENSMUST00000109854.8 Evl F8WJB9 F8WJB9_MOUSE NM_001422023 uc007ozx.1 uc007ozx.2 uc007ozx.3 uc007ozx.4 Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Cytoplasm, cytoskeleton, stress fiber Belongs to the Ena/VASP family. actin binding cytoplasm cytoskeleton actin polymerization or depolymerization SH3 domain binding cell projection actin nucleation protein homotetramerization uc007ozx.1 uc007ozx.2 uc007ozx.3 uc007ozx.4 
ENSMUST00000109856.8 Ankrd48 ENSMUST00000109856.8 ankyrin repeat domain 36, transcript variant 2 (from RefSeq NM_023816.3) Ankrd36 D3Z4K0 D3Z4K0_MOUSE ENSMUST00000109856.1 ENSMUST00000109856.2 ENSMUST00000109856.3 ENSMUST00000109856.4 ENSMUST00000109856.5 ENSMUST00000109856.6 ENSMUST00000109856.7 NM_023816 uc007hwr.1 uc007hwr.2 molecular_function cellular_component biological_process uc007hwr.1 uc007hwr.2 
ENSMUST00000109860.8 Eml1 ENSMUST00000109860.8 echinoderm microtubule associated protein like 1, transcript variant 7 (from RefSeq NM_001364195.1) EMAL1_MOUSE ENSMUST00000109860.1 ENSMUST00000109860.2 ENSMUST00000109860.3 ENSMUST00000109860.4 ENSMUST00000109860.5 ENSMUST00000109860.6 ENSMUST00000109860.7 NM_001364195 Q05AF8 Q05BC3 Q0P5V3 uc007ozs.1 uc007ozs.2 Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. Homotrimer; self-association is mediated by the N-terminal coiled coil (By similarity). Does not interact with EML3 (By similarity). Binds unpolymerized tubulins via its WD repeat region (By similarity). Binds repolymerizing microtubules (PubMed:24859200). Interacts with TASOR (PubMed:31112734). Cytoplasm Cytoplasm, perinuclear region Cytoplasm, cytoskeleton Note=Detected in cytoplasmic punctae. Co-localizes with microtubules. Enriched in perinuclear regions during interphase and in the region of spindle microtubules during metaphase. Enriched at the midzone during telophase and cytokinesis. Detected at growth cones in neurons. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q05BC3-1; Sequence=Displayed; Name=2; IsoId=Q05BC3-2; Sequence=VSP_024477; Name=3; IsoId=Q05BC3-3; Sequence=VSP_024478; Detected in adult brain cortex, hippocampus and thalamus (PubMed:24859200). Expressed in the stomach, lungs and in Sertoli cells of the testis (PubMed:31112734). Detected from 13.5 dpc to the first day after birth in cortical neuron progenitor cells in the ventricular zone and in postmitotic neurons in the cortical plate. Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain. The N-terminal coiled coil is required for association with microtubules. Note=Defects in Eml1 are the cause of the neuronal heterotopia observed in HeCo mice. These mice display heterotopic neurons in the rostro-medial part of the neocortex, together with epilepsy and subtle learning deficits in adults. At 17 dpc both Tbr1(+) and Cux1(+) neurons contribute to the heterotopia. Three days after birth, most Tbr1(+) have reached their final destination, but many Cux1(+) neurons remain in the heterotopia and fail to reach cortical layers II to IV, contrary to the situation in wild-type. Besides, progenitor cells continue to proliferate, resulting in large numbers of abnormally positioned actively proliferating cells during both early and late stages of corticogenesis. In HeCo mice, insertion of a retrotransposon into Eml1 leads to the absence of full-length Eml1 transcripts. Belongs to the WD repeat EMAP family. microtubule cytoskeleton organization hematopoietic progenitor cell differentiation cytoplasm cytosol cytoskeleton microtubule mitotic spindle organization neuroblast proliferation brain development microtubule binding microtubule cytoskeleton tubulin binding perinuclear region of cytoplasm mitotic spindle mitotic spindle pole mitotic spindle midzone uc007ozs.1 uc007ozs.2 
ENSMUST00000109867.8 Znrf3 ENSMUST00000109867.8 zinc and ring finger 3, transcript variant 1 (from RefSeq NM_001080924.2) B2RXA5 ENSMUST00000109867.1 ENSMUST00000109867.2 ENSMUST00000109867.3 ENSMUST00000109867.4 ENSMUST00000109867.5 ENSMUST00000109867.6 ENSMUST00000109867.7 NM_001080924 Q3V095 Q5SSZ7 ZNRF3_MOUSE uc007hwj.1 uc007hwj.2 uc007hwj.3 uc007hwj.4 E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959, PubMed:22895187). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Negatively regulated by R-spondin proteins such as RSPO1: interaction with RSPO1 induces the indirect association between ZNRF3 and LGR4, promoting membrane clearance of ZNRF3. Protein modification; protein ubiquitination. Interacts with LRP6, FZD4, FZD5, FZD6 and FZD8 (By similarity). Interacts with RSPO1; interaction promotes indirect interaction with LGR4 and membrane clearance of ZNRF3 (By similarity). Interacts with LMBR1L (PubMed:31073040). Q5SSZ7; Q2MKA7: RSPO1; Xeno; NbExp=3; IntAct=EBI-21993315, EBI-10045219; Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SSZ7-1; Sequence=Displayed; Name=2; IsoId=Q5SSZ7-2; Sequence=VSP_023089, VSP_023090, VSP_023091; During limb development, at 14.5 dpc, ubiquitously expressed in the limb bud. In developing lungs, at 14.5 dpc, ubiquitously expressed. Embryos die around birth due to activation of Wnt signaling pathway. Embryos display a lack of lens formation due to Wnt activation. Conditional knockout mice lacking both Rnf43 and Znrf3 in intestine show a marked expansion of the proliferative compartment, resembling the effects of acute deletion of Apc. Belongs to the ZNRF3 family. Sequence=AAI51081.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI51084.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ubiquitin-protein transferase activity frizzled binding plasma membrane integral component of plasma membrane ubiquitin-dependent protein catabolic process multicellular organism development membrane integral component of membrane Wnt signaling pathway protein ubiquitination transferase activity negative regulation of Wnt signaling pathway Wnt receptor catabolic process metal ion binding limb development regulation of canonical Wnt signaling pathway ubiquitin protein ligase activity stem cell proliferation negative regulation of canonical Wnt signaling pathway negative regulation of non-canonical Wnt signaling pathway regulation of Wnt signaling pathway, planar cell polarity pathway uc007hwj.1 uc007hwj.2 uc007hwj.3 uc007hwj.4 
ENSMUST00000109869.2 Psmf1 ENSMUST00000109869.2 Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). (from UniProt Q8BHL8) BC131928 ENSMUST00000109869.1 PSMF1_MOUSE Q8BHL8 Q8C0G9 uc290biz.1 uc290biz.2 Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). Monomer and homodimer. Interacts with FBXO7 (By similarity). Cytoplasm Endoplasmic reticulum Belongs to the proteasome inhibitor PI31 family. proteasome complex cytoplasm endoplasmic reticulum cytosol ubiquitin-dependent protein catabolic process protein homodimerization activity protein heterodimerization activity perinuclear region of cytoplasm proteasome binding negative regulation of proteasomal protein catabolic process uc290biz.1 uc290biz.2 
ENSMUST00000109872.2 Tmem74b ENSMUST00000109872.2 Tmem74b (from geneSymbol) 5430405G05Rik A2AU34 A2AU34_MOUSE AK043999 ENSMUST00000109872.1 Tmem74b uc008nej.1 uc008nej.2 uc008nej.3 molecular_function cellular_component biological_process membrane integral component of membrane uc008nej.1 uc008nej.2 uc008nej.3 
ENSMUST00000109888.2 Gm14147 ENSMUST00000109888.2 predicted gene 14147 (from RefSeq NM_001378607.1) A2AQX6 A2AQX6_MOUSE ENSMUST00000109888.1 Gm14147 Gm14151 NM_001378607 uc290bhg.1 uc290bhg.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation intracellular signal transduction uc290bhg.1 uc290bhg.2 
ENSMUST00000109890.2 Gm14151 ENSMUST00000109890.2 predicted gene 14151 (from RefSeq NM_001097977.1) A2AQX6 A2AQX6_MOUSE ENSMUST00000109890.1 Gm14147 Gm14151 NM_001097977 uc008muw.1 uc008muw.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation intracellular signal transduction uc008muw.1 uc008muw.2 
ENSMUST00000109891.3 Bcl11b ENSMUST00000109891.3 B cell leukemia/lymphoma 11B, transcript variant 2 (from RefSeq NM_021399.2) BC11B_MOUSE Ctip2 ENSMUST00000109891.1 ENSMUST00000109891.2 NM_021399 Q8C2I1 Q99PV6 Q99PV7 Q99PV8 Q9JLF8 Rit1 uc007ozi.1 uc007ozi.2 uc007ozi.3 Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals (PubMed:12717433). Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (By similarity). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element. Interacts with TFCOUP1, SIRT1, ARP1 and EAR2 (PubMed:10744719, PubMed:12930829). Interacts with EP300; the interaction is detected in activated T-lymphocytes, but not under resting conditions (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha; IsoId=Q99PV8-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q99PV8-2; Sequence=VSP_009568; Name=3; Synonyms=Gamma; IsoId=Q99PV8-3; Sequence=VSP_009566; Expressed in brain and thymus. Expressed in splenic CD4(+) T-lymphocytes (PubMed:16809611). Highly expressed in the developing embryo. Sumoylated with SUMO1. [Isoform 2]: May be due to exon skipping. [Isoform 3]: May be due to exon skipping. Sequence=AAF63683.1; Type=Frameshift; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding keratinocyte development epithelial cell morphogenesis nucleic acid binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated axonogenesis negative regulation of cell proliferation post-embryonic development regulation of gene expression regulation of keratinocyte proliferation regulation of lipid metabolic process striatal medium spiny neuron differentiation commitment of neuronal cell to specific neuron type in forebrain central nervous system neuron differentiation post-embryonic camera-type eye development T cell differentiation in thymus T cell receptor V(D)J recombination hematopoietic stem cell migration odontogenesis of dentin-containing tooth neuron projection negative regulation of apoptotic process positive T cell selection sequence-specific DNA binding skin development regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter alpha-beta T cell differentiation metal ion binding thymus development olfactory bulb axon guidance lymphoid lineage cell migration into thymus uc007ozi.1 uc007ozi.2 uc007ozi.3 
ENSMUST00000109896.8 Ninl ENSMUST00000109896.8 ninein-like (from RefSeq NM_207204.2) A2ANB8 ENSMUST00000109896.1 ENSMUST00000109896.2 ENSMUST00000109896.3 ENSMUST00000109896.4 ENSMUST00000109896.5 ENSMUST00000109896.6 ENSMUST00000109896.7 Kiaa0980 NINL_MOUSE NM_207204 Nlp Q6NXH6 Q6ZQ12 uc008mut.1 uc008mut.2 uc008mut.3 Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly (By similarity). Involved in vesicle transport in photoreceptor cells (By similarity). Interacts with gamma-tubulin and TUBGCP4. Interacts with anaphase promoting complex/cyclosome (APC/C). Interacts with CDC20 and FZR1. Interacts with LCA5 and USH2A (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm Note=In interphase cells, NLP is transported to the centrosomes by the dynein-dynactin motor complex. During centrosome maturation, PLK1 directly phosphorylates NLP resulting in its release into the cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q6ZQ12-3; Sequence=Displayed; Name=1; IsoId=Q6ZQ12-1; Sequence=VSP_037882; Name=2; IsoId=Q6ZQ12-2; Sequence=VSP_021526; The KEN and D (destructive) boxes are required for the cell cycle-controlled NINL degradation by the APC/C pathway. Phosphorylated by PLK1 which disrupts its centrosome association and interaction with gamma-tubulin. Ubiquitinated by the APC/C complex leading to its degradation. Sequence=BAC98063.1; Type=Erroneous initiation; Evidence=; calcium ion binding cytoplasm centrosome microtubule organizing center cytosol cytoskeleton microtubule microtubule anchoring at centrosome intercellular bridge metal ion binding uc008mut.1 uc008mut.2 uc008mut.3 
ENSMUST00000109901.9 Papola ENSMUST00000109901.9 poly (A) polymerase alpha, transcript variant 4 (from RefSeq NR_186615.1) ENSMUST00000109901.1 ENSMUST00000109901.2 ENSMUST00000109901.3 ENSMUST00000109901.4 ENSMUST00000109901.5 ENSMUST00000109901.6 ENSMUST00000109901.7 ENSMUST00000109901.8 NR_186615 PAPOA_MOUSE Pap Plap Q61183 Q61208 Q61209 Q8K4X2 uc007oyz.1 uc007oyz.2 uc007oyz.3 uc007oyz.4 uc007oyz.5 Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C- terminus. Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, ChEBI:CHEBI:173115; EC=2.7.7.19; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium ions. Also active with manganese. ; Monomer. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with AHCYL1 and FIP1L1; the interaction with AHCYL1 seems to increase interaction with FIP1L1 (PubMed:19224921). Interacts with NUDT21; the interaction is diminished by acetylation. Interacts with KPNB1; the interaction promotes PAP nuclear import and is inhibited by acetylation of PAP (By similarity). Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q61183-1; Sequence=Displayed; Name=2; Synonyms=III; IsoId=Q61183-2; Sequence=VSP_004531, VSP_004532; Name=3; Synonyms=V; IsoId=Q61183-3; Sequence=VSP_004529, VSP_004530; Name=4; Synonyms=VI; IsoId=Q61183-4; Sequence=VSP_004527, VSP_004528; Expressed in brain, thymus, lung, kidney, bladder, testis and spleen. Polysumoylated. Varying sumoylation depending on tissue- and cell- type. Highly sumoylated in bladder and NIH 3T3 cells. Sumoylation is required for nuclear localization and enhances PAP stability. Desumoylated by SENP1. Inhibits polymerase activity. Hyperphosphorylation on multiple CDK2 consensus and non-consensus sites in the C-terminal Ser/Thr-rich region represses PAP activity in late M-phase. Phosphorylation/dephosphorylation may regulate the interaction between PAP and CPSF (By similarity). Acetylated in the C-terminus. Acetylation decreases interaction with NUDT21 and KPNB1, and inhibits nuclear localization through inhibiting binding to the importin alpha/beta complex (By similarity). Belongs to the poly(A) polymerase family. nucleotide binding magnesium ion binding RNA binding polynucleotide adenylyltransferase activity protein binding ATP binding nucleus nucleoplasm cytoplasm mRNA polyadenylation mRNA processing transferase activity nucleotidyltransferase activity manganese ion binding RNA 3'-end processing regulation of mRNA 3'-end processing RNA polyadenylation metal ion binding uc007oyz.1 uc007oyz.2 uc007oyz.3 uc007oyz.4 uc007oyz.5 
ENSMUST00000109905.5 Tmed9 ENSMUST00000109905.5 transmembrane p24 trafficking protein 9 (from RefSeq NM_026211.3) ENSMUST00000109905.1 ENSMUST00000109905.2 ENSMUST00000109905.3 ENSMUST00000109905.4 Gp25l2 NM_026211 Q99KF1 Q9CX02 TMED9_MOUSE uc007qrs.1 uc007qrs.2 uc007qrs.3 uc007qrs.4 Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 (By similarity). Monomer and homodimer in endoplasmic reticulum. Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum- Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED7 and TMED10. Interacts with TMED5. Interacts (via C- terminus) with COPG1; the interaction involves dimeric TMED9. Interacts with PTPN2 and SPAST. Interacts with STX17; the interaction is direct (By similarity). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Golgi apparatus, cis-Golgi network membrane ; Single-pass type I membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein Golgi apparatus, trans-Golgi network membrane ; Single-pass type I membrane protein Note=Cycles between compartments of the early secretatory pathway. N-linked glycosylated containing high mannose. Belongs to the EMP24/GP25L family. Sequence=AAH04691.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi membrane endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus intracellular protein transport ER to Golgi vesicle-mediated transport Golgi organization synaptic vesicle positive regulation of organelle organization protein transport membrane integral component of membrane syntaxin binding ER to Golgi transport vesicle endoplasmic reticulum-Golgi intermediate compartment membrane COPI coating of Golgi vesicle uc007qrs.1 uc007qrs.2 uc007qrs.3 uc007qrs.4 
ENSMUST00000109910.9 Nf2 ENSMUST00000109910.9 neurofibromin 2, transcript variant 3 (from RefSeq NM_010898.4) ENSMUST00000109910.1 ENSMUST00000109910.2 ENSMUST00000109910.3 ENSMUST00000109910.4 ENSMUST00000109910.5 ENSMUST00000109910.6 ENSMUST00000109910.7 ENSMUST00000109910.8 MERL_MOUSE NM_010898 Nf-2 P46662 Q8BR03 uc007hvf.1 uc007hvf.2 uc007hvf.3 uc007hvf.4 Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity). Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium. Interacts with NHERF1, HGS and AGAP2. Interacts with SGSM3. Interacts (via FERM domain) with MPP1 (By similarity). Interacts with LAYN (PubMed:15913605). Interacts with WWC1. Interacts with the CUL4A- RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. The unphosphorylated form interacts (via FERM domain) with VPRBP/DCAF1. Interacts (via FERM domain) with NOP53; the interaction is direct (By similarity). Interacts with SCHIP1; the interaction is direct (By similarity). P46662; Q4VCS5: AMOT; Xeno; NbExp=2; IntAct=EBI-644586, EBI-2511319; P46662; O95835: LATS1; Xeno; NbExp=5; IntAct=EBI-644586, EBI-444209; Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection Cytoplasm, cytoskeleton Nucleus Note=Colocalizes with MPP1 in non-myelin-forming Schwann cells. Binds with DCAF1 in the nucleus. The intramolecular association of the FERM domain with the C-terminal tail promotes nuclear accumulation. The unphosphorylated form accumulates predominantly in the nucleus while the phosphorylated form is largely confined to the non-nuclear fractions (By similarity). Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P46662-1; Sequence=Displayed; Name=2; IsoId=P46662-2; Sequence=VSP_000493; Phosphorylation of Ser-518 inhibits nuclear localization by disrupting the intramolecular association of the FERM domain with the C-terminal tail. The dephosphorylation of Ser-518 favors the interaction with NOP53. Ubiquitinated by the CUL4A-RBX1-DDB1-DCAF1/VprBP E3 ubiquitin- protein ligase complex for ubiquitination and subsequent proteasome- dependent degradation. Mice are born with abnormally small lenses with serious structural defects. Failure of lens vesicle separation and the resulting changes in cell organization causes lenses to herniate, leading to expulsion of lens fiber cells through a perforation in the cornea. Developing lenses show loss of cell apical-basal polarity, failure of the lens vesicle to separate from the surface ectoderm, failure to properly exit the cell cycle during fiber cell differentiation and incomplete terminal differentiation of fiber cells. mesoderm formation ruffle actin binding integrin binding protein binding nucleus nucleolus cytoplasm early endosome cytosol cytoskeleton plasma membrane adherens junction negative regulation of protein kinase activity ectoderm development brain development beta-catenin binding cytoskeletal protein binding negative regulation of cell proliferation Schwann cell proliferation regulation of gliogenesis membrane protein domain specific binding hippocampus development negative regulation of cell-cell adhesion lamellipodium actin cytoskeleton organization filopodium negative regulation of cell growth cortical actin cytoskeleton regulation of protein stability cleavage furrow macromolecular complex regulation of hippo signaling regulation of cell proliferation odontogenesis of dentin-containing tooth negative regulation of tyrosine phosphorylation of STAT protein regulation of apoptotic process cell projection neuron projection negative regulation of MAPK cascade cell body membrane raft apical part of cell synapse cell-cell junction organization positive regulation of cell differentiation negative regulation of JAK-STAT cascade perinuclear region of cytoplasm regulation of neurogenesis positive regulation of stress fiber assembly regulation of cell cycle lens fiber cell differentiation regulation of stem cell proliferation regulation of protein localization to nucleus regulation of neural precursor cell proliferation uc007hvf.1 uc007hvf.2 uc007hvf.3 uc007hvf.4 
ENSMUST00000109913.9 Nr3c2 ENSMUST00000109913.9 nuclear receptor subfamily 3, group C, member 2, transcript variant 5 (from RefSeq NM_001426578.1) A3KN90 A3KN90_MOUSE ENSMUST00000109913.1 ENSMUST00000109913.2 ENSMUST00000109913.3 ENSMUST00000109913.4 ENSMUST00000109913.5 ENSMUST00000109913.6 ENSMUST00000109913.7 ENSMUST00000109913.8 NM_001426578 Nr3c2 uc292bds.1 uc292bds.2 Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated zinc ion binding receptor complex sequence-specific DNA binding metal ion binding positive regulation of NIK/NF-kappaB signaling uc292bds.1 uc292bds.2 
ENSMUST00000109914.2 Zfp345 ENSMUST00000109914.2 zinc finger protein 345 (from RefSeq NM_001034900.3) A2AQA1 A2AQA1_MOUSE ENSMUST00000109914.1 NM_001034900 Zfp345 uc008mub.1 uc008mub.2 uc008mub.3 Nucleus nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc008mub.1 uc008mub.2 uc008mub.3 
ENSMUST00000109916.8 Zfp442 ENSMUST00000109916.8 zinc finger protein 442 (from RefSeq NM_001310645.1) A2AQA0 A2AQA0_MOUSE ENSMUST00000109916.1 ENSMUST00000109916.2 ENSMUST00000109916.3 ENSMUST00000109916.4 ENSMUST00000109916.5 ENSMUST00000109916.6 ENSMUST00000109916.7 NM_001310645 ZIPO-II Zfp442 uc057bot.1 uc057bot.2 uc057bot.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc057bot.1 uc057bot.2 uc057bot.3 
ENSMUST00000109922.2 Zfp1005 ENSMUST00000109922.2 zinc finger protein 1005 (from RefSeq NM_001142410.1) A2AU83 A2AU83_MOUSE ENSMUST00000109922.1 Gm14124 NM_001142410 Zfp1005 uc012cft.1 uc012cft.2 nucleic acid binding DNA binding regulation of transcription, DNA-templated metal ion binding uc012cft.1 uc012cft.2 
ENSMUST00000109923.9 Dbn1 ENSMUST00000109923.9 drebrin 1, transcript variant 3 (from RefSeq NM_019813.5) A2CG16 DREB_MOUSE Drba ENSMUST00000109923.1 ENSMUST00000109923.2 ENSMUST00000109923.3 ENSMUST00000109923.4 ENSMUST00000109923.5 ENSMUST00000109923.6 ENSMUST00000109923.7 ENSMUST00000109923.8 NM_019813 Q3V234 Q922X1 Q9QXS5 Q9QXS6 uc011yzu.1 uc011yzu.2 uc011yzu.3 Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (By similarity). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (By similarity). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (PubMed:25865831). Involved in memory-related synaptic plasticity in the hippocampus (PubMed:25865831). Interacts with RUFY3 (PubMed:24720729). Interacts with CXCR4; this interaction is enhanced by antigenic stimulation (By similarity). Interacts (via ADF-H domain) with ZMYND8 (via N-terminus); the interaction leads to sequestering of ZMYND8 in the cytoplasm (By similarity). Cytoplasm Cell projection, dendrite Cytoplasm, cell cortex Cell junction Cell projection Cell projection, growth cone Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (By similarity). Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (PubMed:24720729). Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=A; IsoId=Q9QXS6-1; Sequence=Displayed; Name=A2; IsoId=Q9QXS6-2; Sequence=VSP_004199, VSP_004200; Name=E2; IsoId=Q9QXS6-3; Sequence=VSP_004198; Expressed in the hippocampus, with expression in the pyramidal cells of CA1, CA2 and CA3 and in the granule cells of the dentate gyrus (at protein level) (PubMed:25865831). Highly expressed in brain, also present in stomach and to a lesser degree in kidney, colon, and urinary bladder (PubMed:10633083). The E2 isoform is specifically expressed in adult stomach, kidney, and cultured cells (PubMed:10633083). Mice are born at the expected Mendelian frequency (PubMed:25865831). Mutant mice exhibit significant reduction of dendritic spine numbers, altered dendritic spine morphology with a reduction in the number of mushroom, thin and stubby types of dendritic spines, decreased protein levels of the neurotransmitter receptors DRD1, DRD2, HTR1A and 5HT7R and reduced numbers of DRD1 receptors on dendritic spines (PubMed:25865831). Inhibited memory-related high- frequency-induced synaptic strengthening (PubMed:25865831). in utero embryonic development actin binding protein binding profilin binding cytoplasm cytoskeleton plasma membrane cell-cell junction gap junction cell cortex actin filament organization multicellular organism development nervous system development cytoskeletal protein binding cell communication by chemical coupling cell communication by electrical coupling positive regulation of cell-substrate adhesion positive regulation of neuron projection development postsynaptic density actin cytoskeleton membrane lamellipodium cell junction cell differentiation filopodium dendrite growth cone site of polarized growth regulation of actin filament polymerization cortical actin cytoskeleton positive regulation of synaptic plasticity negative regulation of actin filament bundle assembly asymmetric synapse maintenance of protein location in cell cell projection neuronal cell body dendritic spine dendritic shaft axonal growth cone axonal spine neuron spine postsynaptic membrane positive regulation of axon extension perinuclear region of cytoplasm generation of neurons neuron projection morphogenesis actin filament binding cytoplasmic sequestering of protein regulation of filopodium assembly excitatory synapse prepulse inhibition positive regulation of dendritic spine morphogenesis neural precursor cell proliferation cellular response to tumor necrosis factor cellular response to transforming growth factor beta stimulus negative regulation of locomotion involved in locomotory behavior modulation of inhibitory postsynaptic potential postsynaptic actin cytoskeleton postsynaptic actin cytoskeleton organization glutamatergic synapse postsynaptic cytosol positive regulation of substrate adhesion-dependent cell spreading positive regulation of receptor localization to synapse dendritic filopodium regulation of postsynaptic density protein 95 clustering negative regulation of muscle filament sliding negative regulation of actin-dependent ATPase activity positive regulation of excitatory postsynaptic potential actin filament uc011yzu.1 uc011yzu.2 uc011yzu.3 
ENSMUST00000109926.8 Zfp1004 ENSMUST00000109926.8 Zfp1004 (from geneSymbol) A2ANU6 A2ANU6_MOUSE ENSMUST00000109926.1 ENSMUST00000109926.2 ENSMUST00000109926.3 ENSMUST00000109926.4 ENSMUST00000109926.5 ENSMUST00000109926.6 ENSMUST00000109926.7 Gm14139 Zfp1004 uc012cfr.1 uc012cfr.2 uc012cfr.3 nucleic acid binding cellular_component uc012cfr.1 uc012cfr.2 uc012cfr.3 
ENSMUST00000109935.8 Syndig1 ENSMUST00000109935.8 synapse differentiation inducing 1, transcript variant 9 (from RefSeq NM_001409847.1) A2ANU3 ENSMUST00000109935.1 ENSMUST00000109935.2 ENSMUST00000109935.3 ENSMUST00000109935.4 ENSMUST00000109935.5 ENSMUST00000109935.6 ENSMUST00000109935.7 NM_001409847 SYNG1_MOUSE Tmem90b uc012cfp.1 uc012cfp.2 uc012cfp.3 May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation. Homodimer. Interacts with GRIA1 and GRIA2. Cell membrane ; Single-pass type II membrane protein Early endosome membrane ; Single-pass type II membrane protein Postsynaptic density membrane Synapse Cell projection, dendrite Cell projection, dendritic spine Note=Shuttles between the cell surface and early endosome membrane. Brain-specific. Expressed in Purkinje neurons in cerebellum. Also detected in the hippocampus. Found at excitatory synapses and postsynaptic cells. Expressed during synaptogenesis. Found at the cell surface of excitatory synapses. Belongs to the CD225/Dispanin family. endosome plasma membrane integral component of plasma membrane intracellular protein transport postsynaptic density membrane integral component of membrane cell junction dendrite early endosome membrane glutamate receptor binding protein homodimerization activity cell projection dendritic spine dendritic shaft intracellular membrane-bounded organelle cell body synapse postsynaptic membrane positive regulation of synapse assembly excitatory synapse synaptic vesicle clustering presynapse Golgi membrane uc012cfp.1 uc012cfp.2 uc012cfp.3 
ENSMUST00000109936.3 Clmn ENSMUST00000109936.3 calmin, transcript variant 7 (from RefSeq NR_104439.1) CLMN_MOUSE ENSMUST00000109936.1 ENSMUST00000109936.2 NR_104439 Q8C5W0 Q91V71 Q91XT7 Q91XT8 Q91XU9 uc011yrj.1 uc011yrj.2 uc011yrj.3 [Isoform 1]: Membrane ; Single-pass type IV membrane protein Note=Shows a reticular pattern in the cytoplasm. [Isoform 4]: Membrane ; Single-pass type IV membrane protein Note=Shows a reticular pattern in the cytoplasm. [Isoform 2]: Cytoplasm. [Isoform 3]: Cytoplasm. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Beta; IsoId=Q8C5W0-1; Sequence=Displayed; Name=2; Synonyms=Delta; IsoId=Q8C5W0-2; Sequence=VSP_007766, VSP_007767; Name=3; Synonyms=Gamma; IsoId=Q8C5W0-3; Sequence=VSP_007768, VSP_007769; Name=4; Synonyms=Alpha; IsoId=Q8C5W0-4; Sequence=VSP_007770; Expressed in testis. Expressed during testis maturation process and in maturing spermatids. In brain, it is expressed in neurons of the hippocampus, cerebral cortex, and thalamus, Purkinje cells, and also in the choroid plexus and ependymal cells. Expressed predominantly in dendrites and cell bodies of the neurons, but not in axons. The level of expression increases during the period of maturation of the mouse brain after birth. [Isoform 2]: Lacks the transmembrane domain. [Isoform 3]: Lacks the transmembrane domain. actin binding nuclear outer membrane cytoplasm nuclear migration negative regulation of cell proliferation membrane integral component of membrane neuron projection development LINC complex actin filament binding nucleus localization cytoskeletal anchoring at nuclear membrane uc011yrj.1 uc011yrj.2 uc011yrj.3 
ENSMUST00000109938.8 Cst5 ENSMUST00000109938.8 May play a role in the last steps of the chondrocyte differentiation pathway as an inducer of maturation (PubMed:13679380). Induces chondrocyte calcification during endochondral ossification by playing a role in the transcriptional inhibition of ENPP1, a generator of pyrophosphate which inhibits calcification (PubMed:16680148). Possibly impairs the binding of a transcription factor to the ENPP1 promoter (PubMed:16680148). Unlike other cystatins, does not have thiol protease inhibitor activity (PubMed:16680148). (from UniProt Q9JM84) A2ART7 BC048364 CST10_MOUSE Cst10 DD72 ENSMUST00000109938.1 ENSMUST00000109938.2 ENSMUST00000109938.3 ENSMUST00000109938.4 ENSMUST00000109938.5 ENSMUST00000109938.6 ENSMUST00000109938.7 Q9JM84 uc290bep.1 uc290bep.2 May play a role in the last steps of the chondrocyte differentiation pathway as an inducer of maturation (PubMed:13679380). Induces chondrocyte calcification during endochondral ossification by playing a role in the transcriptional inhibition of ENPP1, a generator of pyrophosphate which inhibits calcification (PubMed:16680148). Possibly impairs the binding of a transcription factor to the ENPP1 promoter (PubMed:16680148). Unlike other cystatins, does not have thiol protease inhibitor activity (PubMed:16680148). Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JM84-1; Sequence=Displayed; Name=2; IsoId=Q9JM84-2; Sequence=VSP_058422; In cartilage, expressed mainly in mature chondrocytes including prehypertrophic and hypertrophic cells (at protein level) (PubMed:13679380). Expressed exclusively in cartilage (PubMed:11856874). In maturing chondrocytes, expression appears at day 3 and increases thereafter. By high phosphate diet. No visible phenotype. Microscopic decrease in the calcification of hypertrophic chondrocytes at the growth plate. Belongs to the cystatin family. chondrocyte differentiation endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular region extracellular space cytoplasm cytosol negative regulation of endopeptidase activity biomineral tissue development cell maturation uc290bep.1 uc290bep.2 
ENSMUST00000109948.8 Hormad2 ENSMUST00000109948.8 Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation. (from UniProt Q5SQP1) AK015939 B7ZMW2 ENSMUST00000109948.1 ENSMUST00000109948.2 ENSMUST00000109948.3 ENSMUST00000109948.4 ENSMUST00000109948.5 ENSMUST00000109948.6 ENSMUST00000109948.7 HORM2_MOUSE Q5SQP1 Q9D507 uc287whm.1 uc287whm.2 Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation. Interacts with HORMAD1. Nucleus. Chromosome. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SQP1-1; Sequence=Displayed; Name=2; IsoId=Q5SQP1-2; Sequence=VSP_024605, VSP_024606; Specifically expressed in meiotic germ cells. Phosphorylated in a SPO11-dependent manner. Male mice are infertile due to spermatocyte loss as a result of characteristic impairment of sex body formation. Spermatocyte apoptosis is confined to the stage IV seminiferous tubules. In contrast to males, female mice are fertile. synaptonemal complex protein binding nucleus chromosome meiotic sister chromatid cohesion meiotic cell cycle uc287whm.1 uc287whm.2 
ENSMUST00000109955.10 Cstl1 ENSMUST00000109955.10 cystatin-like 1, transcript variant 2 (from RefSeq NM_177655.4) CSTL1_MOUSE Cstl1 ENSMUST00000109955.1 ENSMUST00000109955.2 ENSMUST00000109955.3 ENSMUST00000109955.4 ENSMUST00000109955.5 ENSMUST00000109955.6 ENSMUST00000109955.7 ENSMUST00000109955.8 ENSMUST00000109955.9 NM_177655 Q3V2I7 Q64FK4 Q64FK5 Q80Y72 Rcet1 uc008mtj.1 uc008mtj.2 uc008mtj.3 Secreted Event=Alternative splicing; Named isoforms=2; Name=2 ; IsoId=Q80Y72-1; Sequence=Displayed; Name=1 ; IsoId=Q80Y72-2; Sequence=VSP_058947; Highly expressed in testis where it localizes to spermatogonium, spermatocyes and round spermatids. Not detected in spermatozoa. Also detected in epididymis, cerebrum and pituitary. In testis, expression levels increase from postnatal week 4 onwards with peak levels at postnatal week 8. Expression remains high thereafter. Belongs to the cystatin family. cysteine-type endopeptidase inhibitor activity extracellular region negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc008mtj.1 uc008mtj.2 uc008mtj.3 
ENSMUST00000109957.3 Serpina3j ENSMUST00000109957.3 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J (from RefSeq NM_001101472.2) D3Z451 D3Z451_MOUSE ENSMUST00000109957.1 ENSMUST00000109957.2 NM_001101472 Serpina3j uc011yrg.1 uc011yrg.2 uc011yrg.3 Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular space negative regulation of endopeptidase activity uc011yrg.1 uc011yrg.2 uc011yrg.3 
ENSMUST00000109958.3 Serpina3i ENSMUST00000109958.3 serine (or cysteine) peptidase inhibitor, clade A, member 3I (from RefSeq NM_001199940.1) D3Z450 D3Z450_MOUSE ENSMUST00000109958.1 ENSMUST00000109958.2 NM_001199940 Serpina3i uc011yrf.1 uc011yrf.2 uc011yrf.3 Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular space negative regulation of endopeptidase activity response to cytokine response to peptide hormone uc011yrf.1 uc011yrf.2 uc011yrf.3 
ENSMUST00000109961.8 Nxt1 ENSMUST00000109961.8 NTF2-related export protein 1, transcript variant 1 (from RefSeq NM_001110159.1) ENSMUST00000109961.1 ENSMUST00000109961.2 ENSMUST00000109961.3 ENSMUST00000109961.4 ENSMUST00000109961.5 ENSMUST00000109961.6 ENSMUST00000109961.7 NM_001110159 NXT1_MOUSE Q3THE3 Q9D1P7 Q9QZV9 uc012cfn.1 uc012cfn.2 uc012cfn.3 Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (By similarity). Heterodimer with NXF1. Forms a complex with RANGAP1, RANBP2/NUP358 and NXF1. Interacts (via NTF2 domain) with NXF1. Stabilizes the NTF2 domain of NXF1 by heterodimerization. The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export. Preferentially binds Ran-GTP. Associates with NXF2, NXF3 and NXF5. Does not bind nucleoporins (NPC) directly, its association to NPC is mediated by NXF1. Nucleus. Nucleus speckle Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. protein binding nucleus nuclear pore nucleoplasm cytoplasm cytosol RNA export from nucleus protein import into nucleus protein export from nucleus nucleocytoplasmic transport Ran GTPase binding protein transport nuclear speck nuclear pore central transport channel mRNA transport uc012cfn.1 uc012cfn.2 uc012cfn.3 
ENSMUST00000109962.4 Sstr4 ENSMUST00000109962.4 somatostatin receptor 4 (from RefSeq NM_009219.3) A0A0R4J1D6 A0A0R4J1D6_MOUSE ENSMUST00000109962.1 ENSMUST00000109962.2 ENSMUST00000109962.3 NM_009219 Sstr4 uc008mtc.1 uc008mtc.2 uc008mtc.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity somatostatin receptor activity cytoplasm plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane cell migration forebrain development somatostatin signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to glucocorticoid stimulus positive regulation of arachidonic acid secretion uc008mtc.1 uc008mtc.2 uc008mtc.3 
ENSMUST00000109964.8 Foxa2 ENSMUST00000109964.8 forkhead box A2, transcript variant 3 (from RefSeq NM_001291067.1) ENSMUST00000109964.1 ENSMUST00000109964.2 ENSMUST00000109964.3 ENSMUST00000109964.4 ENSMUST00000109964.5 ENSMUST00000109964.6 ENSMUST00000109964.7 Foxa2 G5E8P5 G5E8P5_MOUSE NM_001291067 uc008mta.1 uc008mta.2 uc008mta.3 Nucleus RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription factor binding negative regulation of epithelial to mesenchymal transition protein domain specific binding cell junction regulation of blood coagulation endocrine pancreas development negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter dopaminergic neuron differentiation uc008mta.1 uc008mta.2 uc008mta.3 
ENSMUST00000109966.8 Zfp707 ENSMUST00000109966.8 zinc finger protein 707, transcript variant 2 (from RefSeq NM_001347040.2) D3Z445 D3Z445_MOUSE ENSMUST00000109966.1 ENSMUST00000109966.2 ENSMUST00000109966.3 ENSMUST00000109966.4 ENSMUST00000109966.5 ENSMUST00000109966.6 ENSMUST00000109966.7 NM_001347040 Zfp707 uc007whw.1 uc007whw.2 uc007whw.3 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007whw.1 uc007whw.2 uc007whw.3 
ENSMUST00000109968.3 Pax1 ENSMUST00000109968.3 paired box 1 (from RefSeq NM_008780.2) A2ALJ9 ENSMUST00000109968.1 ENSMUST00000109968.2 NM_008780 P09084 PAX1_MOUSE Pax-1 Q9R2B1 uc008msx.1 uc008msx.2 uc008msx.3 uc008msx.4 uc008msx.5 This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column. Nucleus. Note=Undulated (un) homozygous mice exhibits vertebral malformations along the entire rostro-caudal axis. This is due to a single mutation in the paired box region. Sequence=AAA37793.1; Type=Erroneous gene model prediction; Evidence=; Sequence=AAA39888.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development somitogenesis DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated multicellular organism development pattern specification process cell proliferation animal organ morphogenesis CD4-positive, alpha-beta T cell differentiation CD8-positive, alpha-beta T cell differentiation positive regulation of transcription from RNA polymerase II promoter thymus development parathyroid gland development bone morphogenesis sclerotome development uc008msx.1 uc008msx.2 uc008msx.3 uc008msx.4 uc008msx.5 
ENSMUST00000109993.9 Tcn2 ENSMUST00000109993.9 Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. (from UniProt O88968) AK170401 ENSMUST00000109993.1 ENSMUST00000109993.2 ENSMUST00000109993.3 ENSMUST00000109993.4 ENSMUST00000109993.5 ENSMUST00000109993.6 ENSMUST00000109993.7 ENSMUST00000109993.8 O88968 Q3TD34 Q3UP69 Q5SQ21 TCO2_MOUSE uc007htz.1 uc007htz.2 uc007htz.3 uc007htz.4 uc007htz.5 Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Interacts with CD320 (via LDL-receptor class A domains). Secreted Belongs to the eukaryotic cobalamin transport proteins family. extracellular region extracellular space ion transport cobalt ion transport cobalamin transport cobalamin binding metal ion binding uc007htz.1 uc007htz.2 uc007htz.3 uc007htz.4 uc007htz.5 
ENSMUST00000109997.10 Zfp961 ENSMUST00000109997.10 zinc finger protein 961 (from RefSeq NM_001164581.1) E9Q4R5 E9Q4R5_MOUSE ENSMUST00000109997.1 ENSMUST00000109997.2 ENSMUST00000109997.3 ENSMUST00000109997.4 ENSMUST00000109997.5 ENSMUST00000109997.6 ENSMUST00000109997.7 ENSMUST00000109997.8 ENSMUST00000109997.9 NM_001164581 Zfp961 uc012gfw.1 uc012gfw.2 uc012gfw.3 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc012gfw.1 uc012gfw.2 uc012gfw.3 
ENSMUST00000110000.8 Naa20 ENSMUST00000110000.8 N(alpha)-acetyltransferase 20, NatB catalytic subunit, transcript variant 1 (from RefSeq NM_001141965.1) ENSMUST00000110000.1 ENSMUST00000110000.2 ENSMUST00000110000.3 ENSMUST00000110000.4 ENSMUST00000110000.5 ENSMUST00000110000.6 ENSMUST00000110000.7 NAA20_MOUSE NM_001141965 Nat5 P61600 Q14B28 Q4VAC3 Q9D7H8 Q9H0Y4 Q9NQH6 Q9Y6D2 uc008mry.1 uc008mry.2 uc008mry.3 Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration. Reaction=acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl- [protein]; Xref=Rhea:RHEA:50484, Rhea:RHEA-COMP:12694, Rhea:RHEA- COMP:12695, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133356, ChEBI:CHEBI:133358; EC=2.3.1.254; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl- [protein]; Xref=Rhea:RHEA:50492, Rhea:RHEA-COMP:12698, Rhea:RHEA- COMP:12699, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133361, ChEBI:CHEBI:133362; EC=2.3.1.254; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]; Xref=Rhea:RHEA:50480, Rhea:RHEA-COMP:12692, Rhea:RHEA-COMP:12693, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133045, ChEBI:CHEBI:133063; EC=2.3.1.254; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]; Xref=Rhea:RHEA:50488, Rhea:RHEA-COMP:12696, Rhea:RHEA-COMP:12697, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133359, ChEBI:CHEBI:133360; EC=2.3.1.254; Evidence=; Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25. Cytoplasm Nucleus Belongs to the acetyltransferase family. ARD1 subfamily. peptide alpha-N-acetyltransferase activity nucleus cytoplasm cytosol N-acetyltransferase activity transferase activity transferase activity, transferring acyl groups N-terminal peptidyl-methionine acetylation NatB complex uc008mry.1 uc008mry.2 uc008mry.3 
ENSMUST00000110002.8 Zfp882 ENSMUST00000110002.8 zinc finger protein 882 (from RefSeq NM_001166645.1) E9Q4R4 E9Q4R4_MOUSE ENSMUST00000110002.1 ENSMUST00000110002.2 ENSMUST00000110002.3 ENSMUST00000110002.4 ENSMUST00000110002.5 ENSMUST00000110002.6 ENSMUST00000110002.7 NM_001166645 Zfp882 uc009mey.1 uc009mey.2 uc009mey.3 uc009mey.4 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc009mey.1 uc009mey.2 uc009mey.3 uc009mey.4 
ENSMUST00000110005.8 Rin2 ENSMUST00000110005.8 Ras and Rab interactor 2, transcript variant 3 (from RefSeq NM_001406509.1) A8Y5L0 ENSMUST00000110005.1 ENSMUST00000110005.2 ENSMUST00000110005.3 ENSMUST00000110005.4 ENSMUST00000110005.5 ENSMUST00000110005.6 ENSMUST00000110005.7 NM_001406509 Q3U6Z8 Q3UAK3 Q3UC54 Q99K06 Q9D684 RIN2_MOUSE uc290bbl.1 uc290bbl.2 Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP (By similarity). Homotetramer; probably composed of anti-parallel linkage of two parallel dimers. Interacts with Ras. Interacts with RAB5B, with a much higher affinity for GTP-bound activated RAB5B. Does not interact with other members of the Rab family (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D684-1; Sequence=Displayed; Name=2; IsoId=Q9D684-2; Sequence=VSP_007581; Belongs to the RIN (Ras interaction/interference) family. Sequence=AAH05529.1; Type=Erroneous initiation; Evidence=; Sequence=AAH40390.3; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; Sequence=BAB29425.1; Type=Erroneous initiation; Evidence=; Sequence=BAC30697.1; Type=Erroneous initiation; Evidence=; Sequence=BAE29760.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; Sequence=BAE30311.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; Sequence=BAE31576.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; molecular_function GTPase activator activity cellular_component cytoplasm endocytosis signal transduction biological_process positive regulation of GTPase activity uc290bbl.1 uc290bbl.2 
ENSMUST00000110009.4 Arc ENSMUST00000110009.4 activity regulated cytoskeletal-associated protein, transcript variant 2 (from RefSeq NM_001276684.1) ARC_MOUSE Arc ENSMUST00000110009.1 ENSMUST00000110009.2 ENSMUST00000110009.3 NM_001276684 Q9ES15 Q9WV31 uc007wfo.1 uc007wfo.2 uc007wfo.3 uc007wfo.4 Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system (By similarity). ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation (By similarity). ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons (By similarity). Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long- term memory (PubMed:29264923, PubMed:24094104, PubMed:31151856). Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis (PubMed:17088213, PubMed:20211139, PubMed:20228806). Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses (PubMed:23791196). Accumulates at weaker synapses, probably to prevent their undesired enhancement (By similarity). This suggests that ARC-containing virion- like capsids may be required to eliminate synaptic material (By similarity). Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (PubMed:17088210, PubMed:20228806). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (PubMed:22036569). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (PubMed:28783680). Homooligomer; homooligomerizes into virion-like capsids (PubMed:31151856). Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2 (By similarity). Interacts with CAMK2B (in the kinase inactive state); leading to target ARC to inactive synapses (By similarity). Interacts with PSEN1 (PubMed:22036569). Interacts with GRIN2A and GRIN2B; inhibiting homooligomerization (By similarity). Q9WV31; P28652: Camk2b; NbExp=2; IntAct=EBI-397779, EBI-397029; Q9WV31; Q62108: Dlg4; NbExp=7; IntAct=EBI-397779, EBI-300895; Q9WV31; PRO_0000025597 [P49769]: Psen1; NbExp=2; IntAct=EBI-397779, EBI-5260983; Extracellular vesicle membrane ; Lipid-anchor Postsynaptic cell membrane ; Lipid-anchor Synapse Postsynaptic density Early endosome membrane Cell projection, dendrite Cytoplasm, cytoskeleton Cytoplasm, cell cortex Cell projection, dendritic spine Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasmic vesicle, clathrin- coated vesicle membrane Note=Forms virion-like extracellular vesicles that are released from neurons (By similarity). Enriched in postsynaptic density of dendritic spines (By similarity). Targeted to inactive synapses following interaction with CAMK2B in the kinase inactive state (By similarity). Accumulation at weaker synapses may be required to prevent their undesired enhancement (By similarity). Associated with the cell cortex of neuronal soma and dendrites (By similarity). Associated with the sperm tail (PubMed:12493697). Expressed in brain and testis (PubMed:12493697). In primary visual cortex, detected in all cortical layers with the exception of layer 5: present at highest level in layers 2/3 and 4, the predominant sites of ocular dominance plasticity (at protein level) (PubMed:20228806). Also expressed in skin-migratory dendritic cells (PubMed:28783680). Ubiquitously expressed in early mouse embryos (PubMed:10727859). Detectable in brain from postnatal week 1, in testis from postnatal week 3. Arc expression is regulated at transcription, post- transcription and translation levels (PubMed:19116276, PubMed:24094104). Expression is induced by neuronal and synaptic activity (PubMed:19116276, PubMed:24094104). Ubiquitinated by UBE3A, leading to its degradation by the proteasome, thereby promoting AMPA receptors (AMPARs) expression at synapses (PubMed:20211139). Ubiquitinated by RNF216 at Lys-268 and Lys- 269 limiting ARC protein levels induced by synaptic activity and thus regulating ARC-dependent forms of synaptic plasticity (By similarity). Palmitoylation anchors the protein into the membrane by allowing direct insertion into the hydrophobic core of the lipid bilayer. Phosphorylation at Ser-260 by CaMK2 prevents homooligomerization into virion-like capsids by disrupting an interaction surface essential for high-order oligomerization (PubMed:31151856). Phosphorylation by CaMK2 inhibits synaptic activity (PubMed:31151856). Mice show deficits in several forms of long-term memory formation including spatial and fear-related learning, conditioned taste aversion as well as long-term object recognition (PubMed:17088210). They show enhanced early-phase but impaired late- phase long-term potentiation (LTP) as well as impaired long-term depression (LTD). Neurons lacking Arc show an increase in surface levels of AMPA receptors (PubMed:17088210). In the visual cortex, mice are impervious to the effects of deprivation or experience: mice do not exhibit depression of deprived-eye responses or a shift in ocular dominance after brief monocular deprivation (PubMed:20228806). Although mice exhibit normal visual acuity, baseline ocular dominance is abnormal and resemble that observed after dark-rearing (PubMed:20228806). Mice also show schizophrenia-related phenotypes characterized by deficits in sensorimotor gating, cognitive functions, social behaviors and amphetamine-induced psychomotor responses (PubMed:27524619). Divergent alterations between the prefrontal cortex and striatal dopaminergic system that capture aspects of schizophrenia- related neuropathophysiology are observed (PubMed:27524619). Knockout mice show a relative loss of high-frequency electroencephalogram activity in hippocampus, as well as a decrease in phase locking of spikes to electroencephalogram oscillations (PubMed:27038743). Widely used as activity-dependent neuronal marker to identify recently activated neurons in behavioral studies. Belongs to the ARC/ARG3.1 family. Genetic disruption of the protein-coding gene was initially reported to cause early embryonic lethality (PubMed:10727859). However, only a partial deletion of the coding region was performed, leading to dominant-negative effects (PubMed:10727859). A complete deletion of the coding region later showed that mice are viable and display deficits in several forms of long-term memory formation (PubMed:17088210). acrosomal vesicle RNA binding mRNA binding actin binding protein binding cytoplasm endosome cytoskeleton plasma membrane cell cortex endocytosis cytoskeleton organization multicellular organism development endoderm development learning long-term memory anterior/posterior pattern specification postsynaptic density actin cytoskeleton membrane cell migration regulation of cell morphogenesis cell junction dendrite cytoplasmic vesicle early endosome membrane cell projection dendritic spine membrane raft synapse postsynaptic membrane regulation of neuronal synaptic plasticity modulation of synaptic transmission mRNA transport protein homooligomerization regulation of dendritic spine morphogenesis postsynaptic density membrane postsynaptic endosome glutamatergic synapse regulation of long-term synaptic potentiation regulation of long term synaptic depression extracellular vesicle positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc007wfo.1 uc007wfo.2 uc007wfo.3 uc007wfo.4 
ENSMUST00000110030.10 Snx5 ENSMUST00000110030.10 sorting nexin 5, transcript variant 1 (from RefSeq NM_001199188.2) ENSMUST00000110030.1 ENSMUST00000110030.2 ENSMUST00000110030.3 ENSMUST00000110030.4 ENSMUST00000110030.5 ENSMUST00000110030.6 ENSMUST00000110030.7 ENSMUST00000110030.8 ENSMUST00000110030.9 NM_001199188 Q543N9 Q9D8U8 SNX5_MOUSE uc008mqr.1 uc008mqr.2 uc008mqr.3 uc008mqr.4 uc008mqr.5 uc008mqr.6 Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin. Plays a role in the internalization of EGFR after EGF stimulation. Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C and is retromer-independent. Together with PIP5K1C facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E- cadherin degradation (By similarity). Plays a role in macropinocytosis (PubMed:18854019). Forms heterodimers with BAR domain-containing sorting nexins SNX1 and SNX2; does not homodimerize. The heterodimers are proposed to self-assemble into helical arrays on the membrane to stabilize and expand local membrane curvature underlying endosomal tubule formation. Thought to be a component of the originally described retromer complex (also called SNX-BAR retromer) which is a pentamer containing the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. Interacts with SNX1, SNX2, VPS26A, VPS29, VPS35, DCTN1, DOCK1, MIB1, PIP5K1C. Interacts with HGS; increased by PIP5K1C kinase activity and by PtdIns(3P) and/or PtdIns(3,4)P2 (By similarity). Q9D8U8; P0DJI4: incE; Xeno; NbExp=4; IntAct=EBI-643385, EBI-22303778; Endosome Early endosome Early endosome membrane ; Peripheral membrane protein; Cytoplasmic side. Cell membrane ; Peripheral membrane protein; Cytoplasmic side Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2) (By similarity). Detected on macropinosomes (PubMed:18854019). Targeted to membrane ruffles in response to EGFR stimulation (By similarity). Detected in macrophages (at protein level). The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5- bisphosphate. The BAR domain is able to sense membrane curvature upon dimerization. Membrane remodeling seems to implicate insertion of an amphipathic helix (AH) in the membrane (By similarity). Belongs to the sorting nexin family. The selectivity for particular phosphatidylinositol lipids is under debate. According to one report (PubMed:19553671), the rat protein binds exclusively to phosphatidylinositol 4,5-bisphosphate, while the human protein has been reported (PubMed:15561769) to bind to phosphatidylinositol 3,4-bisphosphate and also to phosphatidylinositol 3-phosphate. ruffle phagocytic cup cytoplasm endosome early endosome cytosol plasma membrane brush border intracellular protein transport endocytosis pinocytosis epidermal growth factor catabolic process lipid binding phosphatidylinositol-5-phosphate binding protein transport membrane cytoplasmic vesicle membrane retromer complex extrinsic component of cytoplasmic side of plasma membrane extrinsic component of endosome membrane cytoplasmic vesicle D1 dopamine receptor binding early endosome membrane dynactin binding phosphatidylinositol binding positive regulation of renal sodium excretion retrograde transport, endosome to Golgi cell projection negative regulation of blood pressure phosphatidylinositol-4-phosphate binding macropinocytic cup phosphatidylinositol-3,5-bisphosphate binding tubular endosome uc008mqr.1 uc008mqr.2 uc008mqr.3 uc008mqr.4 uc008mqr.5 uc008mqr.6 
ENSMUST00000110043.8 Patz1 ENSMUST00000110043.8 Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:18241078, PubMed:22886576, PubMed:33898458). Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (By similarity). Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (By similarity). (from UniProt Q5NBY9) BC043035 ENSMUST00000110043.1 ENSMUST00000110043.2 ENSMUST00000110043.3 ENSMUST00000110043.4 ENSMUST00000110043.5 ENSMUST00000110043.6 ENSMUST00000110043.7 PATZ1_MOUSE Patz1 Q5NBY9 uc287wcx.1 uc287wcx.2 Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:18241078, PubMed:22886576, PubMed:33898458). Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (By similarity). Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (By similarity). Homodimer (PubMed:32496219). Interacts with RNF4. Interacts (via C-terminus) with TP53; this interaction inhibits TP53 ability to activate transcription (By similarity). Nucleus Widely expressed at high levels during embryogenesis, especially in the central nervous system, especially to the actively proliferating neuroblasts in the periventricular neocortical neuroepithelium, in the telencephalic cortical plate and in the hippocampus (PubMed:22886576). Also expressed in a stage-specific manner in the mouse germinal epithelium (PubMed:18241078). While strongly expressed during brain development,m its expression turns down in adult brain (PubMed:33898458). Mutant mice mostly die in utero or soon after birth likely because of developmental defects in the cardiac outflow tract and/or neural tube closure (PubMed:22886576, PubMed:33898458). Few mice that reach the adult life, equally distributed between males and females, show a dwarf phenotype likely due to defects in cell proliferation (PubMed:22886576). Deletion gene also results in disruption of the testis cytoarchitecture and block of spermatogenesis (PubMed:18241078). negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding chromatin binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated spermatogenesis male gonad development regulation of gene expression negative regulation of endothelial cell migration T cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated uc287wcx.1 uc287wcx.2 
ENSMUST00000110049.8 Eif4enif1 ENSMUST00000110049.8 eukaryotic translation initiation factor 4E nuclear import factor 1, transcript variant 1 (from RefSeq NM_023743.2) 4ET_MOUSE Clast4 ENSMUST00000110049.1 ENSMUST00000110049.2 ENSMUST00000110049.3 ENSMUST00000110049.4 ENSMUST00000110049.5 ENSMUST00000110049.6 ENSMUST00000110049.7 Eif4enif1 NM_023743 Q8CFW0 Q9CSS3 Q9EST3 uc007hse.1 uc007hse.2 uc007hse.3 uc007hse.4 EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:25456498). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (By similarity). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (PubMed:25456498). Promotes miRNA-mediated translational repression (By similarity). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (By similarity). Required for the formation of P-bodies (By similarity). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (By similarity). Interacts (via YXXXXLphi motif) with EIF4E (PubMed:16343815). Interacts (via YXXXXLphi motif) with EIF4E2 (By similarity). Interacts with DDX6. Interacts with CSDE1/UNR (By similarity). Interacts with CNOT1; promoting association with the CCR4-NOT complex (By similarity). Interacts with LSM14A; promoting EIF4ENIF1 localization to P-bodies (By similarity). Interacts with PATL1 (By similarity). Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha (By similarity). Interacts with APOBEC3G in an RNA-dependent manner (By similarity). Cytoplasm Nucleus Nucleus, PML body Nucleus speckle Note=Predominantly cytoplasmic (By similarity). Mainly localizes to processing bodies (P-bodies) (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1- dependent manner. Localization to nuclear foci and speckles requires active transcription (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Clast4-L ; IsoId=Q9EST3-1; Sequence=Displayed; Name=2; Synonyms=Clast4-S ; IsoId=Q9EST3-2; Sequence=VSP_003785; Highly expressed in developing oocytes. Intrinsically disordered protein with multiple low-complexity regions that confer binding to multiple RNA translation, deadenylation and decapping factors. The YXXXXLphi motif mediates interaction with eIF4E (EIF4E and EIF4E2). Phosphorylation by MAPK8/JNK1 and or MAPK9/JNK2 in response to oxidative stress promotes P-body assembly (By similarity). Phosphorylated during meiotic maturation (PubMed:16343815). Belongs to the 4E-T/EIF4E-T family. P-body mRNA binding nuclear export signal receptor activity protein binding nucleus cytoplasm cytosol protein transport PML body nuclear speck negative regulation of translation stem cell population maintenance intracellular membrane-bounded organelle negative regulation of neuron differentiation nuclear export uc007hse.1 uc007hse.2 uc007hse.3 uc007hse.4 
ENSMUST00000110054.8 Use1 ENSMUST00000110054.8 SNARE that may be involved in targeting and fusion of Golgi- derived retrograde transport vesicles with the ER. (from UniProt Q9CQ56) BC075695 ENSMUST00000110054.1 ENSMUST00000110054.2 ENSMUST00000110054.3 ENSMUST00000110054.4 ENSMUST00000110054.5 ENSMUST00000110054.6 ENSMUST00000110054.7 Q3TUK0 Q80V73 Q99MB6 Q9CQ56 USE1_MOUSE Use1l uc292auk.1 uc292auk.2 SNARE that may be involved in targeting and fusion of Golgi- derived retrograde transport vesicles with the ER. Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18 (By similarity). Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQ56-1; Sequence=Displayed; Name=2; IsoId=Q9CQ56-2; Sequence=VSP_012666, VSP_012667; Belongs to the USE1 family. endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum organization protein transport membrane integral component of membrane vesicle-mediated transport regulation of ER to Golgi vesicle-mediated transport endoplasmic reticulum tubular network organization uc292auk.1 uc292auk.2 
ENSMUST00000110057.3 Flrt3 ENSMUST00000110057.3 fibronectin leucine rich transmembrane protein 3, transcript variant 2 (from RefSeq NM_178382.4) ENSMUST00000110057.1 ENSMUST00000110057.2 FLRT3_MOUSE Flrt3 Kiaa1469 NM_178382 Q6ZPQ1 Q8BGT1 uc012cfb.1 uc012cfb.2 uc012cfb.3 Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners (PubMed:19056886, PubMed:25374360). Plays a role in the spatial organization of brain neurons (PubMed:25374360). Plays a role in vascular development in the retina (PubMed:25374360). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:22405201, PubMed:25374360). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (PubMed:21673655, PubMed:25374360). Promotes neurite outgrowth (in vitro) (By similarity). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length (By similarity). Plays a role in the regulation of the density of glutamaergic synapses (PubMed:22405201). Plays a role in fibroblast growth factor-mediated signaling cascades (PubMed:16872596). Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning (PubMed:19056886). Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development (PubMed:18448090). Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (PubMed:19056886). Monomer and homodimer (By similarity). Self-associates (via leucine-rich repeats), giving rise to homooligomers (PubMed:25374360). Interacts with FGFR1 (PubMed:16872596). Interacts (via extracellular domain) with ADGRL1/LPHN1 and LPHN2 (via olfactomedin-like domain) (PubMed:22405201). Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain) (PubMed:24739570, PubMed:22405201, PubMed:26235031). Interacts (via extracellular domain) with UNC5B (via Ig domain) (PubMed:19492039, PubMed:21673655, PubMed:22405201, PubMed:25374360). May also interact (via extracellular domain) with UNC5A and UNC5C (PubMed:22405201). Interacts (via extracellular domain) with UNC5D (via extracellular domain) (PubMed:19492039). Identified in complexes composed of FLRT3, ADGRL3 and UNC5B, respectively FLRT3, ADGRL3 and UNC5D (By similarity). Interacts (via cytoplasmic domain) with ROBO1 (PubMed:24560577). Q8BGT1; Q80TS3: Adgrl3; NbExp=6; IntAct=EBI-16166902, EBI-770665; Q8BGT1; P12023: App; NbExp=2; IntAct=EBI-16166902, EBI-78814; Cell membrane ingle-pass membrane protein Endoplasmic reticulum membrane Cell junction, focal adhesion Secreted Cell projection, axon Cell projection, growth cone membrane Note=Detected on dendritic punctae that colocalize in part with glutamaergic synapses, but not with GABAergic synapses. Proteolytic cleavage in the juxtamembrane region gives rise to a shedded ectodomain (PubMed:21673655). Detected in adult brain (PubMed:21350012). Detected in embryonic rostral thalamus neurons (at protein level) (PubMed:24560577). Detected in embryonic rostral thalamus neurons (PubMed:24560577). Detected in neonate eye, in the inner plexiform layer and the outer nuclear layer (PubMed:25374360). Detected in embryonic brain at 13 dpc. Levels in brain decrease gradually after 15 dpc, but expression continues after birth (PubMed:21673655). Detected in embryonic myocardium, body wall and pro-epicardial organ at 9.5 dpc. Detected throughout the myocardium at 10.5 dpc, but levels in the epicardial cell layer are strongly decreased. Almost exclusively detected in the neural tube at 14.5 dpc (at protein level) (PubMed:21350012). Detected in the chorion and visceral endoderm between 6 and 8 dpc (PubMed:19056886). Detected in the visceral endoderm at 7 dpc, with a gradient from high expression in the anterior part to low expression at the posterior part (PubMed:19056886). At 8 dpc, detected in definitve endoderm, parts of the neuroectoderm, the headfold and posterior mesoderm (PubMed:19056886). Detected in the developing brain, the proepicardial organ and in somites at 8.5 dpc (PubMed:16872596, PubMed:18448090). At 9.5 and 10.5 dpc, detected in telencephalic vesicles, at the midbrain boundaries with forebrain and hindbrain, the hypothalamic region, in the apical ectodermal ridge, pharyngeal arches, the developing eye, the epithelial structures surrounding the lower region of the developing heart, limb buds and somites (PubMed:16872596, PubMed:18448090). At 10.5 dpc, detected at interlimb somites with loss of expression at limb somites and anterior trunk somites. At 11 dpc, detected in mesoderm in head and branchial arches, migrating germ cells and limbs (PubMed:16872596). Up-regulated by FGF2. N-glycosylated. Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease. Heterozygous mice are viable and fertile, but homozygous mice display nearly complete embryonic lethality. Most embryos die at about 10.5 dpc (PubMed:18448090, PubMed:19056886). A majority present disruption of the basement membrane and ruptures of the anterior visceral endoderm (PubMed:19056886). About one third display a pronounced defect in the fusion of the lateral edges of the body wall, resulting in cardia bifida. Mutant mice display also a defect in proepicardial cell migration. About one third of the mutants display abnormal morphogenesis of the neuroepithelium and headfold fusion defects. Besides, mutant embryos display defects in definitive endoderm migration, resulting in anterior axis truncations. Each of these phenotypes has partial penetrance, and many mutant embryos present a spectrum of defects. About 3% of the mutants develop into viable and fertile adults (PubMed:18448090, PubMed:19056886). Sequence=BAC98179.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; proepicardium cell migration involved in pericardium morphogenesis fibroblast growth factor receptor binding protein binding extracellular region extracellular space endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane integral component of plasma membrane cell-cell junction focal adhesion cell adhesion multicellular organism development axon guidance synapse assembly heart development fibroblast growth factor receptor signaling pathway postsynaptic density membrane integral component of membrane cell junction axon neuron projection development protein homodimerization activity cell projection axon terminus axonal growth cone chemorepellent activity embryonic morphogenesis response to axon injury synapse organization negative chemotaxis positive regulation of synapse assembly head development synaptic membrane cell-cell adhesion via plasma-membrane adhesion molecules glutamatergic synapse integral component of postsynaptic membrane synaptic membrane adhesion neuron projection extension uc012cfb.1 uc012cfb.2 uc012cfb.3 
ENSMUST00000110064.8 Macrod2 ENSMUST00000110064.8 mono-ADP ribosylhydrolase 2, transcript variant 13 (from RefSeq NM_001406394.1) ENSMUST00000110064.1 ENSMUST00000110064.2 ENSMUST00000110064.3 ENSMUST00000110064.4 ENSMUST00000110064.5 ENSMUST00000110064.6 ENSMUST00000110064.7 MACD2_MOUSE Macrod2 NM_001406394 Q3UYG8 uc008mpv.1 uc008mpv.2 uc008mpv.3 Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Reaction=2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+); Xref=Rhea:RHEA:57060, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:83767; Evidence=; Reaction=4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose + H(+) + L-aspartyl-[protein]; Xref=Rhea:RHEA:54428, Rhea:RHEA- COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29961, ChEBI:CHEBI:57967, ChEBI:CHEBI:138102; Evidence=; Reaction=5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = ADP-D-ribose + H(+) + L-glutamyl-[protein]; Xref=Rhea:RHEA:58248, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:57967, ChEBI:CHEBI:142540; Evidence=; Reaction=alpha-NAD(+) + H2O = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:68792, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57967, ChEBI:CHEBI:77017; Evidence=; Subject to product inhibition by ADP-ribose. Interacts with ADP-ribosylated PARP1. Nucleus Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. Expressed in the kidney. At 12.5 dpc, expressed in the neural tube and in the dorsal root and cranial ganglia. At 14.5 dpc, expressed in metanephric glomeruli, but not in the medullary region of the kidney, in the epithelium lining the gut, the stomach and the seminiferous tubules, as well as in lung. Expression is maintained in the dorsal root and cranial ganglia. In the cranial region, up-regulated in the epithelial and mesenchymal components of the tooth bud, in the epithelium lining the primitive nasal cavity, the vestibulocochlear and cochlear ducts and in the cranial ganglia. At 16.5 dpc, expression is maintained in kidney and lung. Detected in the papilla of the whisker follicle. In the eye, highly expressed in the cuboid epithelium of the lens and the inner nuclear (neuroblastic) layer of the retina. Expression begins in the brain, in particular the ventricular zone, and in the heart. At 18.5 dpc, expression is maintained in the brain, including the subventricular zone of striatum and olfactory lobe, the cortical plate, the cerebellar primordium and the inferior colliculus of the tectum. At this stage, the expression in the heart is 45 times lower than in the brain. At birth, still detectable in the metanephric glomeruli, but not in the adrenal gland. molecular_function cellular_component nucleus nucleolus centrosome cellular response to DNA damage stimulus brain development response to bacterium hydrolase activity hydrolase activity, acting on glycosyl bonds deacetylase activity purine nucleoside metabolic process protein de-ADP-ribosylation uc008mpv.1 uc008mpv.2 uc008mpv.3 
ENSMUST00000110066.8 Gpr68 ENSMUST00000110066.8 G protein-coupled receptor 68, transcript variant 1 (from RefSeq NM_175493.4) ENSMUST00000110066.1 ENSMUST00000110066.2 ENSMUST00000110066.3 ENSMUST00000110066.4 ENSMUST00000110066.5 ENSMUST00000110066.6 ENSMUST00000110066.7 NM_175493 OGR1_MOUSE Ogr1 Q148P7 Q3U1L3 Q80T34 Q8BFQ3 uc007ota.1 uc007ota.2 uc007ota.3 Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer. Cell membrane; Multi-pass membrane protein. Expressed in the lung, testis, heart, brain, spleen, thymus, brown fat, small intestine, colon, peripheral blood leukocytes, macrophages, stomach, ovary and white fat but not in the liver, kidney, and skeletal muscle. Expression in the prostate is weak but detectable. Mice have reduced osteoclasts derived from bone marrow cells, a pH-dependent osteoclast survival effect is also detected. However, the overall bone structures of the mice are not affected. In addition melanoma cell tumorigenesis is significantly inhibited. Belongs to the G-protein coupled receptor 1 family. Sequence=AAI18035.2; Type=Erroneous initiation; Evidence=; Sequence=AAI18045.2; Type=Erroneous initiation; Evidence=; Sequence=BAC29521.1; Type=Erroneous initiation; Evidence=; Sequence=BAC39863.1; Type=Erroneous initiation; Evidence=; Sequence=BAE33483.1; Type=Erroneous initiation; Evidence=; G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane positive regulation of insulin secretion positive regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of monocyte differentiation cellular response to pH positive regulation of osteoclast development uc007ota.1 uc007ota.2 uc007ota.3 
ENSMUST00000110071.3 Haus8 ENSMUST00000110071.3 4HAUS augmin-like complex, subunit 8, transcript variant 2 (from RefSeq NM_029621.3) ENSMUST00000110071.1 ENSMUST00000110071.2 HAUS8_MOUSE Hice1 NM_029621 Q99L00 Q9CWT4 uc009mcg.1 uc009mcg.2 uc009mcg.3 uc009mcg.4 Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect (By similarity). Interacts with EML3 (phosphorylated at 'Thr-882') and TUBG1 (By similarity). Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=During interphase, primarily cytoplasmic and associates with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity. During anaphase and telophase, additionally associates with the spindle midzone and midbody, respectively. Localizes to mitotic spindle microtubules (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99L00-1; Sequence=Displayed; Name=2; IsoId=Q99L00-2; Sequence=VSP_031544; Belongs to the HAUS8 family. spindle pole molecular_function cytoplasm centrosome microtubule organizing center spindle cytoskeleton microtubule nuclear microtubule cell cycle centrosome cycle spindle assembly cell division HAUS complex uc009mcg.1 uc009mcg.2 uc009mcg.3 uc009mcg.4 
ENSMUST00000110079.9 Tasp1 ENSMUST00000110079.9 taspase, threonine aspartase 1, transcript variant 7 (from RefSeq NR_110352.1) ENSMUST00000110079.1 ENSMUST00000110079.2 ENSMUST00000110079.3 ENSMUST00000110079.4 ENSMUST00000110079.5 ENSMUST00000110079.6 ENSMUST00000110079.7 ENSMUST00000110079.8 NR_110352 Q8R1G1 Q99JP3 TASP1_MOUSE uc008mpi.1 uc008mpi.2 uc008mpi.3 uc008mpi.4 uc008mpi.5 Protease responsible for KMT2A/MLL1 and KMT2D/MLL2 processing and activation (PubMed:16951254). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (PubMed:16951254). Intramolecular proteolysis generates 2 subunits, alpha and beta, which reassemble through a non-covalent association to form the fully active enzyme. Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q8R1G1-1; Sequence=Displayed; Name=2; IsoId=Q8R1G1-2; Sequence=VSP_000334, VSP_000335; Tasp1-null mice are born with no apparent respiratory distress, but the majority dies at postpartum day 1 or 2 with no obvious milk spots, suggesting a feeding defect. Newborns are smaller in size compared to their wild-type littermates. This phenotype appears in utero. Animals that survive the newborn period are markedly smaller through adulthood, and display skeletal abnormalities. Belongs to the Ntn-hydrolase family. Sequence=AAH05776.1; Type=Erroneous initiation; Evidence=; threonine-type endopeptidase activity cytoplasm proteolysis peptidase activity hydrolase activity identical protein binding positive regulation of transcription, DNA-templated protein maturation uc008mpi.1 uc008mpi.2 uc008mpi.3 uc008mpi.4 uc008mpi.5 
ENSMUST00000110082.11 Calm1 ENSMUST00000110082.11 calmodulin 1, transcript variant 2 (from RefSeq NM_009790.5) CALM3_MOUSE Calm3 Cam3 Camc ENSMUST00000110082.1 ENSMUST00000110082.10 ENSMUST00000110082.2 ENSMUST00000110082.3 ENSMUST00000110082.4 ENSMUST00000110082.5 ENSMUST00000110082.6 ENSMUST00000110082.7 ENSMUST00000110082.8 ENSMUST00000110082.9 NM_009790 P02593 P0DP28 P62204 P70667 P99014 Q3TEH7 Q3THK5 Q3U6Z5 Q3U7C7 Q498A3 Q61379 Q61380 Q8BNC9 Q91VQ9 Q9D6G4 uc007osq.1 uc007osq.2 uc007osq.3 uc007osq.4 This gene encodes a member of the EF-hand calcium-binding protein family. The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin- dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Interacts with CEP97, CCP110, MYO1C, TTN/titin and SRY. Interacts with MYO10. Interacts with RRAD (By similarity). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2. Interacts with SCN5A (By similarity). Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with RYR1 (PubMed:18650434). Interacts with MYO5A (By similarity). Interacts with IQCF1 (PubMed:25380116). Interacts with SYT7 (PubMed:24569478). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity). Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:18650434). Interacts with PCP4; regulates calmodulin calcium- binding (By similarity). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel (By similarity). Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. Ubiquitination results in a strongly decreased activity. Phosphorylation results in a decreased activity. This protein has four functional calcium-binding sites. Belongs to the calmodulin family. Sequence=BAC39089.2; Type=Erroneous translation; Note=Wrong CDS prediction.; Evidence=; G2/M transition of mitotic cell cycle spindle pole response to amphetamine regulation of heart rate calcium ion binding detection of calcium ion nucleus cytoplasm centrosome spindle cytoskeleton spindle microtubule plasma membrane activation of adenylate cyclase activity voltage-gated potassium channel complex adenylate cyclase binding adenylate cyclase activator activity regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum calcium-mediated signaling protein kinase binding protein domain specific binding sarcomere nitric-oxide synthase regulator activity growth cone synaptic vesicle membrane titin binding type 3 metabotropic glutamate receptor binding mitochondrial membrane N-terminal myristoylation domain binding regulation of cytokinesis positive regulation of phosphoprotein phosphatase activity macromolecular complex calcium channel complex positive regulation of protein dephosphorylation neuron projection myelin sheath phosphatidylinositol 3-kinase binding ion channel binding metal ion binding protein N-terminus binding calcium-dependent protein binding nitric-oxide synthase binding positive regulation of nitric-oxide synthase activity positive regulation of cyclic-nucleotide phosphodiesterase activity response to corticosterone response to calcium ion regulation of cardiac muscle contraction regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity protein phosphatase activator activity positive regulation by host of symbiont cAMP-mediated signal transduction establishment of protein localization to membrane establishment of protein localization to mitochondrial membrane disordered domain specific binding regulation of synaptic vesicle endocytosis regulation of high voltage-gated calcium channel activity catalytic complex regulation of synaptic vesicle exocytosis uc007osq.1 uc007osq.2 uc007osq.3 uc007osq.4 
ENSMUST00000110087.9 Fgd3 ENSMUST00000110087.9 FYVE, RhoGEF and PH domain containing 3 (from RefSeq NM_015759.2) ENSMUST00000110087.1 ENSMUST00000110087.2 ENSMUST00000110087.3 ENSMUST00000110087.4 ENSMUST00000110087.5 ENSMUST00000110087.6 ENSMUST00000110087.7 ENSMUST00000110087.8 Fgd3 NM_015759 Q3TNB8 Q3TNB8_MOUSE uc007qjd.1 uc007qjd.2 uc007qjd.3 Cytoplasm, cytoskeleton Rho guanyl-nucleotide exchange factor activity regulation of Rho protein signal transduction metal ion binding uc007qjd.1 uc007qjd.2 uc007qjd.3 
ENSMUST00000110089.9 Mkks ENSMUST00000110089.9 McKusick-Kaufman syndrome, transcript variant 1 (from RefSeq NM_021527.2) Bbs6 ENSMUST00000110089.1 ENSMUST00000110089.2 ENSMUST00000110089.3 ENSMUST00000110089.4 ENSMUST00000110089.5 ENSMUST00000110089.6 ENSMUST00000110089.7 ENSMUST00000110089.8 MKKS_MOUSE NM_021527 Q8BGQ3 Q9JI70 uc008moq.1 uc008moq.2 uc008moq.3 uc008moq.4 uc008moq.5 This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Alternatively spliced transcripts encoding distinct isoforms have been found for this gene. [provided by RefSeq, Nov 2013]. Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (By similarity). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:28753627). May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis (By similarity). Component of a complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 and CCT8. Interacts with STUB1. Interacts with BBS2 (via coiled coil domain). Interacts with CCDC28B. Interacts with BBS12. Interacts with SMARCC1, a component of the SWI/SNF complexes; the interaction takes place predominantly in the cytoplasm and may modulate SMARCC1 location (By similarity). Interacts with DLEC1 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytosol Nucleus Note=The majority of the protein resides within the pericentriolar material (PCM), a proteinaceous tube surrounding centrioles. During interphase, the protein is confined to the lateral surfaces of the PCM but during mitosis it relocalizes throughout the PCM and is found at the intercellular bridge. The MKSS protein is highly mobile and rapidly shuttles between the cytosol and centrosome. Widely expressed in adult and fetal tissues. Expressed in the developing heart, brain retina, limb buds, as well as in the developing neural tube. Expressed in the embryo in the first and second branchial arches. Expressed in parafin embedded tissue sections of brain, kidney, retina, olfactory epithelium and the ependymal layer of ventricles. Detected only in restricted regions of these tissue sections, including the ciliated border of renal tubules, the connecting cilium and the inner and outer nuclear layers of retina, and the ciliated layer of olfactory epithelia. Mice demonstrate retinal degeneration, failure of spermatozoa flagella formation, elevated blood pressure, olfactory deficits, and social dominance, but no polydactyly nor vaginal abnormalities. The phenotype closely resembles the phenotype of other mouse models of Bardet-Biedl syndrome (Bbs2 deficient and Bbs4 deficient). Obesity is associated with hyperleptinemia and resistance to the anorectic and weight-reducing effects of leptin. Although mice are resistant to the metabolic actions of leptin, mice remain responsive to the effects of leptin on renal sympathetic nerve activity and arterial pressure and develop hypertension. BBS mice have decreased hypothalamic expression of proopiomelanocortin (POMC). BBS genes play an important role in maintaining leptin sensitivity in POMC neurons. Belongs to the TCP-1 chaperonin family. nucleotide binding RNA polymerase II repressing transcription factor binding ATP binding nucleus cytoplasm centrosome microtubule organizing center cytosol cytoskeleton protein folding spermatid development sensory perception of smell negative regulation of gene expression artery smooth muscle contraction striatum development hippocampus development cerebral cortex development negative regulation of actin filament polymerization motile cilium developmental process leptin-mediated signaling pathway negative regulation of GTPase activity social behavior ciliary basal body negative regulation of appetite by leptin-mediated signaling pathway positive regulation of multicellular organism growth vasodilation response to leptin fat cell differentiation photoreceptor cell maintenance negative regulation of blood pressure intracellular transport brain morphogenesis detection of mechanical stimulus involved in sensory perception of sound unfolded protein binding chaperone-mediated protein complex assembly cartilage development regulation of stress fiber assembly cilium assembly regulation of cilium beat frequency involved in ciliary motility face development kinociliary basal body non-motile cilium assembly uc008moq.1 uc008moq.2 uc008moq.3 uc008moq.4 uc008moq.5 
ENSMUST00000110093.9 Rab3a ENSMUST00000110093.9 Protein transport. Probably involved in vesicular traffic. (from UniProt Q0PD63) BC053519 ENSMUST00000110093.1 ENSMUST00000110093.2 ENSMUST00000110093.3 ENSMUST00000110093.4 ENSMUST00000110093.5 ENSMUST00000110093.6 ENSMUST00000110093.7 ENSMUST00000110093.8 Q0PD63 Q0PD63_MOUSE Rab3A Rab3a uc292arr.1 uc292arr.2 Protein transport. Probably involved in vesicular traffic. Cell membrane ipid-anchor ; Cytoplasmic side toplasmic vesicle, secretory vesicle Lysosome Membrane ; Lipid-anchor ; Cytoplasmic side Postsynapse Presynapse Synapse Belongs to the small GTPase superfamily. Rab family. ATPase activator activity plasma membrane repair GTPase activity GTP binding cytosol exocytosis synaptic vesicle protein C-terminus binding regulation of synaptic vesicle priming membrane synaptic vesicle exocytosis secretory granule axon myosin V binding lysosome localization positive regulation of ATPase activity macromolecular complex synaptic vesicle recycling terminal bouton intracellular organelle regulated exocytosis perinuclear region of cytoplasm GDP-dissociation inhibitor binding ATPase binding acrosomal vesicle exocytosis anchored component of synaptic vesicle membrane positive regulation of regulated secretory pathway regulation of plasma membrane repair regulation of synaptic vesicle exocytosis uc292arr.1 uc292arr.2 
ENSMUST00000110095.3 Pde4c ENSMUST00000110095.3 phosphodiesterase 4C, cAMP specific, transcript variant 1 (from RefSeq NM_001310465.1) ENSMUST00000110095.1 ENSMUST00000110095.2 NM_001310465 PDE4C_MOUSE Pde4c Q3UEI1 Q8K0P4 uc009mbh.1 uc009mbh.2 uc009mbh.3 uc009mbh.4 Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions. ; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 divalent metal cations per subunit (By similarity). Site 2 has a preference for magnesium and/or manganese ions (By similarity). ; Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2. Cell projection, cilium Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UEI1-1; Sequence=Displayed; Name=2; IsoId=Q3UEI1-2; Sequence=VSP_016663; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cilium cAMP catabolic process signal transduction phosphoric diester hydrolase activity hydrolase activity cell projection metal ion binding negative regulation of insulin secretion involved in cellular response to glucose stimulus uc009mbh.1 uc009mbh.2 uc009mbh.3 uc009mbh.4 
ENSMUST00000110098.4 Snap25 ENSMUST00000110098.4 synaptosomal-associated protein 25, transcript variant 14 (from RefSeq NR_182009.1) A2AIC2 A2AIC3 ENSMUST00000110098.1 ENSMUST00000110098.2 ENSMUST00000110098.3 NR_182009 P13795 P36974 P60879 P70557 P70558 Q8IXK3 Q96FM2 Q9BR45 SNP25_MOUSE Snap uc056zpt.1 uc056zpt.2 uc056zpt.3 t-SNARE involved in the molecular regulation of neurotransmitter release (PubMed:8243676, PubMed:8103915). May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF (PubMed:16672379). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (By similarity). Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex constitutes the basic catalytic machinery of the complex neurotransmitter release apparatus (PubMed:19196426, PubMed:28821673). Recruited to the SNARE complex following binding of the SNARE complex component STX1A to STXBP1 (PubMed:28821673). This complex binds CPLX1 (PubMed:19196426). Found in a complex containing SYT1, SV2B and STX1A (PubMed:15466855). Found in a ternary complex with STX1A and VAMP8 (PubMed:9731768). Interacts with HSC70 and with SYT9, forming a complex with DNAJC5 (PubMed:20847230). The interaction with SYT9 is inhibited in presence of calcium (PubMed:20847230). Isoform 1 and isoform 2 interact with BLOC1S6 (PubMed:19546860). Interacts with CENPF (PubMed:16672379). Interacts with EQTN (PubMed:19285662). Interacts with HGS (By similarity). Interacts with KCNB1 (via N- terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells (By similarity). Interacts with OTOF (PubMed:17055430). Interacts with RIMS1 (By similarity). Interacts with SNAPIN (PubMed:10195194). Interacts with STXBP6 (By similarity). Interacts with TRIM9 (By similarity). Interacts with ZDHHC13 (via ANK repeats) (PubMed:25253725). Interacts with ZDHHC17 (via ANK repeats) (PubMed:25253725). Associates with the BLOC-1 complex (PubMed:19546860). Interacts with PLCL1 (via C2 domain) (PubMed:23341457). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex (PubMed:22832103, PubMed:27052163, PubMed:29056747). Interacts with alpha-synuclein/SNCA (PubMed:20798282). Interacts with PRPH2 (PubMed:26406599). Interacts with ROM1 (PubMed:26406599). Interacts with STX3 isoform 3B (PubMed:26406599). P60879; Q155P7: Cenpf; NbExp=13; IntAct=EBI-445270, EBI-2211248; P60879; O35526: Stx1a; NbExp=4; IntAct=EBI-445270, EBI-400878; P60879; P63044: Vamp2; NbExp=18; IntAct=EBI-445270, EBI-521920; P60879; P32851: Stx1a; Xeno; NbExp=7; IntAct=EBI-445270, EBI-539720; Cytoplasm, perinuclear region Cell membrane ; Lipid-anchor Synapse, synaptosome Photoreceptor inner segment Note=Membrane association requires palmitoylation (PubMed:9349529). Expressed throughout cytoplasm, concentrating at the perinuclear region (PubMed:16672379). Colocalizes with KCNB1 at the cell membrane (By similarity). Colocalizes with PLCL1 at the cell membrane (By similarity). Event=Alternative splicing; Named isoforms=2; Comment=Isoforms differ by the usage of two alternative homologous exons (5a and 5b) which code for positions 56 to 94 and differ only in 9 positions out of 39.; Name=1; Synonyms=SNAP-25b; IsoId=P60879-1, P13795-1; Sequence=Displayed; Name=2; Synonyms=SNAP-25a; IsoId=P60879-2, P13795-2; Sequence=VSP_010019; Expressed in the outer nuclear layer of the retina (at protein level). Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type A (BoNT/A, botA) which hydrolyzes the 197-Gln-|-Arg-198 bond and inhibits neurotransmitter release (PubMed:8243676, PubMed:8103915). (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type E (BoNT/E) which hydrolyzes the 180-Arg-|-Ile-181 bond and inhibits neurotransmitter release (PubMed:8243676, PubMed:8103915). Belongs to the SNAP-25 family. SNARE binding voltage-gated potassium channel activity SNAP receptor activity protein binding cytoplasm endosome trans-Golgi network cytosol cytoskeleton plasma membrane exocytosis vesicle fusion neurotransmitter secretion long-term memory locomotory behavior synaptic vesicle voltage-gated potassium channel complex associative learning regulation of neuron projection development actin cytoskeleton membrane synaptic vesicle exocytosis synaptic vesicle priming endosomal transport myosin binding syntaxin-1 binding protein domain specific binding syntaxin binding lamellipodium cell junction filopodium axon growth cone sleep BLOC-1 complex SNARE complex extrinsic component of cytoplasmic side of plasma membrane synaptic vesicle fusion to presynaptic active zone membrane positive regulation of synaptic plasticity vesicle SNARE complex assembly somatodendritic compartment presynaptic membrane neuron projection neuronal cell body myelin sheath intracellular organelle axonal growth cone ion channel binding membrane raft synapse positive regulation of hormone secretion protein N-terminus binding calcium-dependent protein binding perinuclear region of cytoplasm presynaptic active zone membrane calcium ion-regulated exocytosis of neurotransmitter long-term synaptic potentiation synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex synaptobrevin 2-SNAP-25-syntaxin-1a complex regulation of establishment of protein localization potassium ion transmembrane transport postsynapse exocytic insertion of neurotransmitter receptor to postsynaptic membrane glutamatergic synapse anchored component of presynaptic membrane neurotransmitter receptor internalization short-term synaptic potentiation uc056zpt.1 uc056zpt.2 uc056zpt.3 
ENSMUST00000110103.2 Gdf15 ENSMUST00000110103.2 growth differentiation factor 15, transcript variant 2 (from RefSeq NM_001330687.1) ENSMUST00000110103.1 GDF15_MOUSE Gdf15 Mic1 NM_001330687 Q6NX63 Q9Z0J7 Sbf uc292aqx.1 uc292aqx.2 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation. [provided by RefSeq, Aug 2016]. Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886, PubMed:28846097, PubMed:28846099, PubMed:28572090, PubMed:23468844, PubMed:29046435). On hepatocytes, inhibits growth hormone signaling (PubMed:28572090). Homodimer; disulfide-linked (By similarity). Interacts with GFRAL; ligand of GFRAL which mediates GDF15 internalization and cellular signaling through interaction with RET (PubMed:28846098, PubMed:28846099). Secreted Highly expressed in liver (PubMed:10779363, PubMed:28572090, PubMed:29046435). Detected in plasma (at protein level) (PubMed:28572090, PubMed:29046435). Expressed by cardiomyocytes, expression is highly increased in heart diseases (PubMed:28572090). Also detected in subcutaneous fat (PubMed:28572090, PubMed:29046435). At postnatal day 3 (P3), detected in heart and plasma, expression decreases with lower levels at P7 to, at least, P13. Expression is up-regulated by obesity. Mutants weight more, have increases adiposity associated with increased spontaneous food intake and exhibit reduced basal energy expenditure and physical activity (PubMed:23468844). Female mutants exhibit some additional alterations in reduced basal energy expenditure and physical activity (PubMed:23468844). At behavioral level, they exhibit a task-dependent increase in locomotion and exploration and reduced anxiety-related behaviors across tests. Their spatial working memory and social behaviors are not affected. They form an increased association with conditioned stimulus in fear conditioning testing and also display significantly improved prepulse inhibition (PubMed:28081177). Belongs to the TGF-beta family. activation of MAPK activity reduction of food intake in response to dietary excess cytokine activity transforming growth factor beta receptor binding extracellular region extracellular space nucleus cytoplasm Golgi apparatus growth factor activity positive regulation of pathway-restricted SMAD protein phosphorylation BMP signaling pathway glial cell-derived neurotrophic factor receptor signaling pathway negative regulation of multicellular organism growth protein homodimerization activity regulation of apoptotic process regulation of MAPK cascade positive regulation of MAPK cascade cell development positive regulation of protein kinase B signaling SMAD protein signal transduction negative regulation of growth hormone receptor signaling pathway positive regulation of myoblast fusion uc292aqx.1 uc292aqx.2 
ENSMUST00000110105.10 Zc3h14 ENSMUST00000110105.10 zinc finger CCCH type containing 14, transcript variant 1 (from RefSeq NM_029334.2) A0PJE7 A1A4A9 ENSMUST00000110105.1 ENSMUST00000110105.2 ENSMUST00000110105.3 ENSMUST00000110105.4 ENSMUST00000110105.5 ENSMUST00000110105.6 ENSMUST00000110105.7 ENSMUST00000110105.8 ENSMUST00000110105.9 NM_029334 Q3TU70 Q8BIY8 Q8BJ05 Q8R3Q8 Q8R3R2 Q9DAA8 ZC3HE_MOUSE uc007org.1 uc007org.2 uc007org.3 Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides. Interacts with HOOK2. Interacts with ZFC3H1 in a RNase- sensitive manner. Nucleus speckle te=Colocalizes with poly(A) RNA in nuclear speckles. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BJ05-1; Sequence=Displayed; Name=2; IsoId=Q8BJ05-2; Sequence=VSP_033179; Name=3; IsoId=Q8BJ05-3; Sequence=VSP_033180; Name=4; IsoId=Q8BJ05-4; Sequence=VSP_033177, VSP_033178, VSP_033180; Expressed in hippocampal pyramidal neurons (at protein level) (PubMed:21734151).Expressed in kidney, liver, muscle, heart brain and testes (PubMed:19303045). Expressed in hippocampal pyramidal neurons (PubMed:21734151). Belongs to the ZC3H14 family. RNA binding nucleus nucleolus cytoplasm poly(A) binding nuclear speck dendrite cytoplasm regulation of mRNA stability metal ion binding negative regulation of mRNA polyadenylation axon cytoplasm ribonucleoprotein complex uc007org.1 uc007org.2 uc007org.3 
ENSMUST00000110109.8 Plcb4 ENSMUST00000110109.8 phospholipase C, beta 4, transcript variant 2 (from RefSeq NM_013829.3) ENSMUST00000110109.1 ENSMUST00000110109.2 ENSMUST00000110109.3 ENSMUST00000110109.4 ENSMUST00000110109.5 ENSMUST00000110109.6 ENSMUST00000110109.7 NM_013829 Plcb4 Q91UZ1 Q91UZ1_MOUSE uc008mod.1 uc008mod.2 uc008mod.3 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:43484, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57880, ChEBI:CHEBI:58433; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43485; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33180; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; phosphatidylinositol phospholipase C activity calcium ion binding protein binding nucleus cytoplasm smooth endoplasmic reticulum lipid metabolic process signal transduction phosphoric diester hydrolase activity postsynaptic density lipid catabolic process hydrolase activity dendrite inositol trisphosphate biosynthetic process intracellular signal transduction negative regulation of potassium ion transport phosphatidylinositol-mediated signaling modulation of synaptic transmission mitogen-activated protein kinase binding release of sequestered calcium ion into cytosol postsynapse glutamatergic synapse uc008mod.1 uc008mod.2 uc008mod.3 
ENSMUST00000110116.8 Plcb1 ENSMUST00000110116.8 phospholipase C, beta 1, transcript variant 1 (from RefSeq NM_001145830.1) ENSMUST00000110116.1 ENSMUST00000110116.2 ENSMUST00000110116.3 ENSMUST00000110116.4 ENSMUST00000110116.5 ENSMUST00000110116.6 ENSMUST00000110116.7 NM_001145830 PLCB1_MOUSE Plcb Plcb1 Q62075 Q6PDH1 Q8K5A5 Q8K5A6 Q9Z0E5 Q9Z1B3 Q9Z2T5 uc008mny.1 uc008mny.2 uc008mny.3 uc008mny.4 Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5- bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein- coupled receptors (PubMed:27653213). Regulates the function of the endothelial barrier (PubMed:27653213). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33180; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:43484, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57880, ChEBI:CHEBI:58433; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43485; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with DGKQ. Nucleus membrane Cytoplasm Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. Event=Alternative splicing; Named isoforms=3; Name=A; Synonyms=C-beta-1a; IsoId=Q9Z1B3-1; Sequence=Displayed; Name=B; Synonyms=C-beta-1b; IsoId=Q9Z1B3-2; Sequence=VSP_008917; Name=C; IsoId=Q9Z1B3-3; Sequence=VSP_008918; Palmitoylated (PubMed:27653213). Palmitoylation at Cys-17 by ZDHHC21 regulates the signaling activity of PLCB1 and the function of the endothelial barrier (Probable). Palmitoylation by ZDHHC21 is stimulated by inflammation (PubMed:27653213). The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11. G2/M transition of mitotic cell cycle nuclear chromatin oocyte maturation phosphatidylinositol phospholipase C activity GTPase activator activity calcium ion binding protein binding calmodulin binding lamin binding phosphatidylinositol-4,5-bisphosphate binding nucleus cytoplasm cytosol plasma membrane mRNA processing lipid metabolic process cell adhesion signal transduction G-protein coupled acetylcholine receptor signaling pathway glutamate receptor signaling pathway brain development memory phosphoric diester hydrolase activity regulation of G-protein coupled receptor protein signaling pathway insulin receptor signaling pathway membrane lipid catabolic process nuclear speck hydrolase activity enzyme binding cerebral cortex development erythrocyte differentiation macrophage differentiation phosphatidylinositol catabolic process nuclear membrane positive regulation of sodium:proton antiporter activity positive regulation of interleukin-12 production inositol trisphosphate metabolic process inositol trisphosphate biosynthetic process macromolecular complex response to monosaccharide intracellular signal transduction interleukin-12-mediated signaling pathway interleukin-15-mediated signaling pathway positive regulation of embryonic development protein homodimerization activity myelin sheath response to peptide hormone positive regulation of GTPase activity fat cell differentiation positive regulation of myoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of JNK cascade phosphatidylinositol metabolic process insulin-like growth factor receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of developmental growth release of sequestered calcium ion into cytosol regulation of cell cycle activation of meiosis involved in egg activation interleukin-1-mediated signaling pathway regulation of fertilization postsynapse glutamatergic synapse GABA-ergic synapse positive regulation of G1/S transition of mitotic cell cycle cellular response to fluoride cellular response to vasopressin cellular response to ionomycin cellular response to glyceraldehyde positive regulation of acrosome reaction negative regulation of monocyte extravasation positive regulation of CD24 biosynthetic process uc008mny.1 uc008mny.2 uc008mny.3 uc008mny.4 
ENSMUST00000110125.9 Gsdmc ENSMUST00000110125.9 gasdermin C (from RefSeq NM_031378.3) ENSMUST00000110125.1 ENSMUST00000110125.2 ENSMUST00000110125.3 ENSMUST00000110125.4 ENSMUST00000110125.5 ENSMUST00000110125.6 ENSMUST00000110125.7 ENSMUST00000110125.8 GSDMC_MOUSE Gsdmc Gsdmc1 Mlze NM_031378 Q99NB5 uc007vyt.1 uc007vyt.2 uc007vyt.3 [Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis. [Gasdermin-C, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis. Produced by the cleavage of gasdermin-D by caspase CASP8 in response to death signals. After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. [Gasdermin-C]: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C- terminal domains mediate autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-C, N-terminal) following cleavage by caspase CASP8. [Gasdermin-C, N-terminal]: Homooligomer; homooligomeric ring- shaped pore complex containing 27-28 subunits when inserted in the membrane. [Gasdermin-C]: Cytoplasm, cytosol [Gasdermin-C, N-terminal]: Cell membrane ; Multi-pass membrane protein Intramolecular interactions between N- and C-terminal domains are important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain. Cleavage by CASP8 relieves autoinhibition by releasing the N- terminal moiety (Gasdermin-C, N-terminal) that initiates pyroptosis. Belongs to the gasdermin family. Despite its name, does not contain a functional leucine zipper. phosphatidylserine binding molecular_function phosphatidylinositol-4,5-bisphosphate binding cytoplasm mitochondrion microtubule organizing center cytosol plasma membrane biological_process programmed cell death membrane pyroptosis phosphatidylinositol-4-phosphate binding uc007vyt.1 uc007vyt.2 uc007vyt.3 
ENSMUST00000110127.8 Slc25a42 ENSMUST00000110127.8 solute carrier family 25, member 42 (from RefSeq NM_001007570.2) ENSMUST00000110127.1 ENSMUST00000110127.2 ENSMUST00000110127.3 ENSMUST00000110127.4 ENSMUST00000110127.5 ENSMUST00000110127.6 ENSMUST00000110127.7 NM_001007570 Q8R0Y8 S2542_MOUSE uc012gex.1 uc012gex.2 uc012gex.3 Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate. Reaction=ADP(out) + CoA(in) = ADP(in) + CoA(out); Xref=Rhea:RHEA:72839, ChEBI:CHEBI:57287, ChEBI:CHEBI:456216; Evidence=; Reaction=3'-dephospho-CoA(in) + ADP(out) = 3'-dephospho-CoA(out) + ADP(in); Xref=Rhea:RHEA:72843, ChEBI:CHEBI:57328, ChEBI:CHEBI:456216; Evidence=; Reaction=adenosine 3',5'-bisphosphate(in) + ADP(out) = adenosine 3',5'- bisphosphate(out) + ADP(in); Xref=Rhea:RHEA:72847, ChEBI:CHEBI:58343, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(out) + AMP(in) = ADP(in) + AMP(out); Xref=Rhea:RHEA:72851, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(out) + dADP(in) = ADP(in) + dADP(out); Xref=Rhea:RHEA:72855, ChEBI:CHEBI:57667, ChEBI:CHEBI:456216; Evidence=; Reaction=ADP(in) + ATP(out) = ADP(out) + ATP(in); Xref=Rhea:RHEA:34999, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. ATP transmembrane transporter activity mitochondrion mitochondrial inner membrane ADP transmembrane transporter activity coenzyme A transmembrane transporter activity ADP transport ATP transport membrane integral component of membrane transmembrane transporter activity coenzyme A transmembrane transport adenosine-diphosphatase activity transmembrane transport AMP transport AMP transmembrane transporter activity uc012gex.1 uc012gex.2 uc012gex.3 
ENSMUST00000110141.9 Mef2b ENSMUST00000110141.9 Nucleus (from UniProt E9Q2M6) D87834 E9Q2M6 E9Q2M6_MOUSE ENSMUST00000110141.1 ENSMUST00000110141.2 ENSMUST00000110141.3 ENSMUST00000110141.4 ENSMUST00000110141.5 ENSMUST00000110141.6 ENSMUST00000110141.7 ENSMUST00000110141.8 Mef2b uc012get.1 uc012get.2 uc012get.3 uc012get.4 Nucleus RNA polymerase II regulatory region sequence-specific DNA binding DNA binding nucleus positive regulation of transcription from RNA polymerase II promoter protein dimerization activity uc012get.1 uc012get.2 uc012get.3 uc012get.4 
ENSMUST00000110142.8 Gpcpd1 ENSMUST00000110142.8 glycerophosphocholine phosphodiesterase 1, transcript variant 2 (from RefSeq NM_028802.3) A2AMD5 ENSMUST00000110142.1 ENSMUST00000110142.2 ENSMUST00000110142.3 ENSMUST00000110142.4 ENSMUST00000110142.5 ENSMUST00000110142.6 ENSMUST00000110142.7 GPCP1_MOUSE Gde5 Kiaa1434 NM_028802 Prei4 Q3TLV6 Q80TD5 Q8BKJ7 Q8BKW7 Q8C0L9 Q8CFW2 Q9D759 uc290asl.1 uc290asl.2 May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity. Reaction=H2O + sn-glycerol 3-phosphocholine = choline + H(+) + sn- glycerol 3-phosphate; Xref=Rhea:RHEA:16061, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:57597; EC=3.1.4.2; Evidence=; Kinetic parameters: Vmax=2.0 umol/min/mg enzyme with glycerophosphocholine as substrate ; Vmax=0.34 umol/min/mg enzyme with glycerophosphoethanolamine as substrate ; Note=No significant reactions when glycerophosphoglycerol, glycerophosphoinositol and glycerophosphoserine are used as substrates.; Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C0L9-1; Sequence=Displayed; Name=2; IsoId=Q8C0L9-2; Sequence=VSP_020820; Name=3; IsoId=Q8C0L9-3; Sequence=VSP_020819; Widely expressed with highest levels in skeletal muscle and heart. Down-regulated in skeletal muscles atrophies, including atrophies linked to aging and denervation. Belongs to the glycerophosphoryl diester phosphodiesterase family. Sequence=BAB26361.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC33775.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC34739.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC65792.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cytoplasm cytosol lipid metabolic process skeletal muscle tissue development phosphoric diester hydrolase activity glycerophosphodiester phosphodiesterase activity hydrolase activity carbohydrate binding glycerophospholipid catabolic process glycerophosphocholine phosphodiesterase activity starch binding uc290asl.1 uc290asl.2 
ENSMUST00000110145.12 Gm2042 ENSMUST00000110145.12 predicted gene 2042, transcript variant 1 (from RefSeq NM_001270792.1) ENSMUST00000110145.1 ENSMUST00000110145.10 ENSMUST00000110145.11 ENSMUST00000110145.2 ENSMUST00000110145.3 ENSMUST00000110145.4 ENSMUST00000110145.5 ENSMUST00000110145.6 ENSMUST00000110145.7 ENSMUST00000110145.8 ENSMUST00000110145.9 Gm2042 NM_001270792 Oog1 Q5RJV9 Q5RJV9_MOUSE uc007ojo.1 uc007ojo.2 uc007ojo.3 uc007ojo.4 uc007ojo.5 uc007ojo.6 Belongs to the PRAME family. molecular_function cellular_component biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc007ojo.1 uc007ojo.2 uc007ojo.3 uc007ojo.4 uc007ojo.5 uc007ojo.6 
ENSMUST00000110147.3 Eif1ad3 ENSMUST00000110147.3 eukaryotic translation initiation factor 1A domain containing 3 (from RefSeq NM_001122662.1) ENSMUST00000110147.1 ENSMUST00000110147.2 Eif1ad3 Gm2016 NM_001122662 Q3TQZ4 Q3TQZ4_MOUSE uc007ojn.1 uc007ojn.2 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. molecular_function RNA binding translation initiation factor activity cellular_component translation translational initiation biological_process uc007ojn.1 uc007ojn.2 
ENSMUST00000110149.2 Eif1ad2 ENSMUST00000110149.2 eukaryotic translation initiation factor 1A domain containing 2 (from RefSeq NM_001177573.1) BB287469 ENSMUST00000110149.1 Eif1ad2 Eif1ad6 Gm4027 NM_001177573 Q3UT53 Q3UT53_MOUSE uc007ojm.1 uc007ojm.2 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. molecular_function RNA binding translation initiation factor activity cellular_component translation translational initiation biological_process uc007ojm.1 uc007ojm.2 
ENSMUST00000110152.3 Eif1ad8 ENSMUST00000110152.3 eukaryotic translation initiation factor 1A domain containing 8 (from RefSeq NM_001177565.1) ENSMUST00000110152.1 ENSMUST00000110152.2 Eif1ad10 Eif1ad8 Gm8300 Gm8332 NM_001177565 Q3UTA4 Q3UTA4_MOUSE uc011ypn.1 uc011ypn.2 uc011ypn.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. molecular_function RNA binding translation initiation factor activity cellular_component translation translational initiation biological_process uc011ypn.1 uc011ypn.2 uc011ypn.3 
ENSMUST00000110160.9 Tm6sf2 ENSMUST00000110160.9 transmembrane 6 superfamily member 2, transcript variant 1 (from RefSeq NM_001293795.1) E9QM19 E9QM19_MOUSE ENSMUST00000110160.1 ENSMUST00000110160.2 ENSMUST00000110160.3 ENSMUST00000110160.4 ENSMUST00000110160.5 ENSMUST00000110160.6 ENSMUST00000110160.7 ENSMUST00000110160.8 NM_001293795 Tm6sf2 uc009lyq.1 uc009lyq.2 uc009lyq.3 Membrane ; Multi- pass membrane protein Belongs to the TM6SF family. endoplasmic reticulum membrane membrane integral component of membrane regulation of lipid metabolic process endoplasmic reticulum-Golgi intermediate compartment membrane uc009lyq.1 uc009lyq.2 uc009lyq.3 
ENSMUST00000110167.5 Ndufa13 ENSMUST00000110167.5 NADH:ubiquinone oxidoreductase subunit A13, transcript variant 1 (from RefSeq NM_023312.3) ENSMUST00000110167.1 ENSMUST00000110167.2 ENSMUST00000110167.3 ENSMUST00000110167.4 Grim19 NDUAD_MOUSE NM_023312 Q9DC98 Q9DCA1 Q9ERS2 uc009lyd.1 uc009lyd.2 uc009lyd.3 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4. Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side Nucleus Note=Localizes mainly in the mitochondrion. May be translocated into the nucleus upon IFN/RA treatment. Belongs to the complex I NDUFA13 subunit family. Sequence=BAB22505.1; Type=Erroneous initiation; Evidence=; NADH dehydrogenase activity ATP binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial inner membrane mitochondrial respiratory chain mitochondrial respiratory chain complex I apoptotic process NADH dehydrogenase (ubiquinone) activity membrane integral component of membrane negative regulation of cell growth mitochondrial membrane mitochondrial respiratory chain complex I assembly cellular response to interferon-beta positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein import into mitochondrial inner membrane positive regulation of protein catabolic process negative regulation of transcription, DNA-templated oxidation-reduction process respiratory chain cellular response to retinoic acid reactive oxygen species metabolic process apoptotic signaling pathway extrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway uc009lyd.1 uc009lyd.2 uc009lyd.3 
ENSMUST00000110168.8 Zhx1 ENSMUST00000110168.8 zinc fingers and homeoboxes 1, transcript variant 2 (from RefSeq NM_001042438.2) ENSMUST00000110168.1 ENSMUST00000110168.2 ENSMUST00000110168.3 ENSMUST00000110168.4 ENSMUST00000110168.5 ENSMUST00000110168.6 ENSMUST00000110168.7 NM_001042438 P70121 Q8BQ68 Q8C6T4 Q8CJG3 ZHX1_MOUSE uc007vtd.1 uc007vtd.2 uc007vtd.3 uc007vtd.4 Acts as a transcriptional repressor. Increases DNMT3B- mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins (By similarity). Forms homodimers. Heterodimer (via HD1 domain) with ZHX2 (via HD1 domain). Also forms a heterodimer with ZHX3 which is a prerequisite for repressor activity. Interacts with ATF7IP and NFYA. Interacts (via homeobox domains) with DNMT3B (via PWWP domain) (By similarity). Nucleus te=Colocalized in the nucleus with DNMT3B. Widely expressed with highest levels in brain. By interleukin-2. Belongs to the ZHX family. negative regulation of transcription from RNA polymerase II promoter nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity nucleus nucleoplasm regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated metal ion binding protein heterodimerization activity uc007vtd.1 uc007vtd.2 uc007vtd.3 uc007vtd.4 
ENSMUST00000110170.8 Prnd ENSMUST00000110170.8 prion like protein doppel, transcript variant 3 (from RefSeq NM_001278257.1) ENSMUST00000110170.1 ENSMUST00000110170.2 ENSMUST00000110170.3 ENSMUST00000110170.4 ENSMUST00000110170.5 ENSMUST00000110170.6 ENSMUST00000110170.7 NM_001278257 PRND_MOUSE Q9QUG3 Q9QZT5 uc033hqj.1 uc033hqj.2 uc033hqj.3 Required for normal acrosome reaction and for normal male fertility (PubMed:12110578, PubMed:15161660, PubMed:15007175). Can bind Cu(2+) (By similarity). Cell membrane ; Lipid-anchor, GPI-anchor Detected in testis (PubMed:10842180, PubMed:12110578, PubMed:15161660). Detected within seminiferous tubules, on round and elongated spermatids (at protein level) (PubMed:12110578). Not detected in brain (at protein level) (PubMed:10842180, PubMed:15161660). Detected in testis, and at low levels in heart (PubMed:10525406, PubMed:12110578). Expression in brain is very low and barely detectable (PubMed:10525406). Expressed during embryogenesis. A short helical region is required and sufficient for Cu(2+) binding. N-glycosylated (PubMed:10525406, PubMed:10842180). N-glycosylated at two distinct sites (PubMed:10842180). O-glycosylated. Mice are born at the expected Mendelian rate and appear grossly normal and healthy. Females are fertile, but males are almost completely sterile, in spite of normal mating behavior (PubMed:12110578, PubMed:15161660). Two independent studies conclude that male sterility is due to impaired acrosome reaction, but describe contradictory effects on spermatogenesis, possibly due to the use of different mouse strains (PubMed:12110578, PubMed:15161660). Spermatogenesis is normal, with normal sperm counts, normal sperm motility, and no malformation of the sperm head or tail (PubMed:15161660). Late stages of spermiogenesis are impaired, leading to reduced numbers of mature spermatozoa in seminiferous tubules; mutant sperm present morphological abnormalities of the flagellum and sperm head, and decreased motility (PubMed:12110578). Mutant sperm are able to fertilize oocytes in vitro, but many of the resulting embryos die before the morula stage (PubMed:15161660). Mutant sperm cells have elevated levels of DNA damage and DNA strand breaks, and this may be the cause for embryonic lethality (PubMed:15161660). Mice deficient for both Prnd and Prnp have the same phenotype as mice lacking Prnd; they are born at the expected Mendelian rate and appear grossly normal and healthy (PubMed:15161660, PubMed:15007175). Females are fertile, but males deficient for both Prnd and Prnp are sterile, in spite of normal mating behavior (PubMed:15161660, PubMed:15007175). Again, findings about spermatogenesis are contradictory: spermatogenesis is normal, with normal sperm counts, normal sperm motility, and no malformation of the sperm head or tail (PubMed:15161660). Sperm cells display various malformations (PubMed:15007175). Male sterility is due to impaired acrosome reaction (PubMed:15161660). Aging mice deficient for both Prnd and Prnp do not display loss of cerebellar Purkinje cells or develop ataxia, and do not develop neurological defects (PubMed:15007175). Loss of cerebellar Purkinje cells and ataxia has been observed in mice with mutations that cause Prnd overexpression in the brain, suggesting that aberrant overexpression of Prnd causes neurotoxicity. Belongs to the prion family. copper ion binding protein binding plasma membrane cellular copper ion homeostasis single fertilization acrosome reaction membrane anchored component of membrane anchored component of external side of plasma membrane metal ion binding protein homooligomerization spermatogenesis uc033hqj.1 uc033hqj.2 uc033hqj.3 
ENSMUST00000110186.9 Smox ENSMUST00000110186.9 spermine oxidase, transcript variant 1 (from RefSeq NM_001177833.1) A2ANQ8 A2ANQ9 A2ANR0 A2ANR1 A2ANR2 ENSMUST00000110186.1 ENSMUST00000110186.2 ENSMUST00000110186.3 ENSMUST00000110186.4 ENSMUST00000110186.5 ENSMUST00000110186.6 ENSMUST00000110186.7 ENSMUST00000110186.8 NM_001177833 Q70LA3 Q70LA4 Q70LA5 Q70LA7 Q70LA8 Q70LA9 Q70LB0 Q8CJ56 Q8CJ57 Q99K82 SMOX_MOUSE Smo uc008mln.1 uc008mln.2 uc008mln.3 uc008mln.4 Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. Reaction=H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine; Xref=Rhea:RHEA:25804, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:45725, ChEBI:CHEBI:57834, ChEBI:CHEBI:58374; EC=1.5.3.16; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Kinetic parameters: KM=150 uM for spermine ; Amine and polyamine degradation; spermine degradation. Cytoplasm [Isoform 2]: Cytoplasm. Nucleus. Event=Alternative splicing; Named isoforms=10; Name=1; Synonyms=Alpha, Polyamine oxidase-l; IsoId=Q99K82-1; Sequence=Displayed; Name=2; Synonyms=Mu; IsoId=Q99K82-2; Sequence=VSP_011137; Name=3; Synonyms=Eta; IsoId=Q99K82-3; Sequence=VSP_011131; Name=4; Synonyms=Omega; IsoId=Q99K82-4; Sequence=VSP_011128, VSP_011132; Name=5; Synonyms=Phi; IsoId=Q99K82-5; Sequence=VSP_011130; Name=6; Synonyms=Beta; IsoId=Q99K82-6; Sequence=VSP_011136, VSP_011138; Name=7; Synonyms=Gamma; IsoId=Q99K82-7; Sequence=VSP_011135, VSP_011138; Name=8; Synonyms=Polyamine oxidase-m; IsoId=Q99K82-8; Sequence=VSP_011134; Name=9; Synonyms=Polyamine oxidase-s; IsoId=Q99K82-9; Sequence=VSP_011129, VSP_011133; Name=10; Synonyms=Delta; IsoId=Q99K82-10; Sequence=VSP_011127; Widely expressed. Isoform 1 and isoform 2 are expressed at higher level in brain and skeletal muscle. Isoform 7 is found in brain and spleen, isoform 10 is widely expressed but found at lower level in heart, kidney, liver and lung. By antitumor polyamine analogs. [Isoform 1]: Major isoform. [Isoform 2]: Active. Nuclear and cytoplasmic. [Isoform 7]: No detectable activity. Cytoplasmic. [Isoform 10]: No detectable activity. Cytoplasmic. Belongs to the flavin monoamine oxidase family. nucleus nucleoplasm cytoplasm polyamine catabolic process oxidoreductase activity nuclear membrane intracellular membrane-bounded organelle spermine catabolic process polyamine oxidase activity norspermine:oxygen oxidoreductase activity N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity spermine:oxygen oxidoreductase (spermidine-forming) activity oxidation-reduction process uc008mln.1 uc008mln.2 uc008mln.3 uc008mln.4 
ENSMUST00000110191.10 Gcnt2 ENSMUST00000110191.10 glucosaminyl (N-acetyl) transferase 2 (I blood group), transcript variant 2 (from RefSeq NM_023887.5) ENSMUST00000110191.1 ENSMUST00000110191.2 ENSMUST00000110191.3 ENSMUST00000110191.4 ENSMUST00000110191.5 ENSMUST00000110191.6 ENSMUST00000110191.7 ENSMUST00000110191.8 ENSMUST00000110191.9 Gcnt2 Ignt1 NM_023887 Q6T5E4 Q6T5E4_MOUSE uc007qel.1 uc007qel.2 uc007qel.3 uc007qel.4 Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 14 family. Golgi apparatus protein glycosylation transforming growth factor beta receptor signaling pathway N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity acetylglucosaminyltransferase activity posttranscriptional regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of cell-substrate adhesion membrane integral component of membrane transferase activity positive regulation of cell migration positive regulation of heterotypic cell-cell adhesion maintenance of lens transparency positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade uc007qel.1 uc007qel.2 uc007qel.3 uc007qel.4 
ENSMUST00000110196.8 Slc22a22 ENSMUST00000110196.8 solute carrier family 22 (organic cation transporter), member 22, transcript variant 1 (from RefSeq NM_172378.3) ENSMUST00000110196.1 ENSMUST00000110196.2 ENSMUST00000110196.3 ENSMUST00000110196.4 ENSMUST00000110196.5 ENSMUST00000110196.6 ENSMUST00000110196.7 NM_172378 Oat-pg Q8R0S9 S22AM_MOUSE Slc22a22 uc007vso.1 uc007vso.2 Sodium-independent organic anion transporter which exhibits high specificity for a subset of prostaglandins including prostaglandin E2 (PGE2), prostaglandin E1 (PGE1), prostaglandin F2-alpha (PGF2-alpha) and prostaglandin D2 (PGD2). Kinetic parameters: KM=118.3 nM for prostaglandin E2 ; KM=158.2 nM for prostaglandin F2-alpha ; KM=156.8 nM for prostaglandin E1 ; KM=371.6 nM for prostaglandin D2 ; Vmax=6.32 pmol/min/mg enzyme toward prostaglandin E2 ; Vmax=4.61 pmol/min/mg enzyme toward prostaglandin F2-alpha ; Vmax=2.71 pmol/min/mg enzyme toward prostaglandin E1 ; Vmax=8.95 pmol/min/mg enzyme toward prostaglandin D2 ; Temperature dependence: High activity at 37 degrees Celsius. Little or no activity at 0 degrees Celsius. ; Basolateral cell membrane ; Multi-pass membrane protein Specifically expressed in kidney where it is found in proximal convoluted tubules (at protein level). Colocalizes with the prostaglandin-inactivating enzyme HPGD in kidney (at protein level). Not detected in other tissues tested. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. prostaglandin receptor activity plasma membrane integral component of plasma membrane ion transport G-protein coupled receptor signaling pathway membrane integral component of membrane basolateral plasma membrane transmembrane transporter activity transmembrane transport sodium-independent prostaglandin transport uc007vso.1 uc007vso.2 
ENSMUST00000110204.9 Esrrb ENSMUST00000110204.9 estrogen related receptor, beta, transcript variant 1 (from RefSeq NM_011934.4) ENSMUST00000110204.1 ENSMUST00000110204.2 ENSMUST00000110204.3 ENSMUST00000110204.4 ENSMUST00000110204.5 ENSMUST00000110204.6 ENSMUST00000110204.7 ENSMUST00000110204.8 Esrrb G5E8P8 G5E8P8_MOUSE NM_011934 uc007ohv.1 uc007ohv.2 uc007ohv.3 uc007ohv.4 Nucleus Belongs to the nuclear hormone receptor family. NR3 subfamily. DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity steroid binding nucleus regulation of transcription, DNA-templated zinc ion binding stem cell population maintenance steroid hormone mediated signaling pathway sequence-specific DNA binding positive regulation of glycogen biosynthetic process positive regulation of glycolytic process metal ion binding uc007ohv.1 uc007ohv.2 uc007ohv.3 uc007ohv.4 
ENSMUST00000110208.8 Ap5s1 ENSMUST00000110208.8 adaptor-related protein 5 complex, sigma 1 subunit, transcript variant 2 (from RefSeq NM_001291031.1) 2310035K24Rik A2ANC6 A2ANC6_MOUSE Ap5s1 ENSMUST00000110208.1 ENSMUST00000110208.2 ENSMUST00000110208.3 ENSMUST00000110208.4 ENSMUST00000110208.5 ENSMUST00000110208.6 ENSMUST00000110208.7 NM_001291031 uc008mlb.1 uc008mlb.2 uc008mlb.3 uc008mlb.4 double-strand break repair via homologous recombination endosomal transport AP-type membrane coat adaptor complex uc008mlb.1 uc008mlb.2 uc008mlb.3 uc008mlb.4 
ENSMUST00000110214.9 Gm6871 ENSMUST00000110214.9 Gm6871 (from geneSymbol) ENSMUST00000110214.1 ENSMUST00000110214.2 ENSMUST00000110214.3 ENSMUST00000110214.4 ENSMUST00000110214.5 ENSMUST00000110214.6 ENSMUST00000110214.7 ENSMUST00000110214.8 Gm6871 L7N248 L7N248_MOUSE uc291ovt.1 uc291ovt.2 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc291ovt.1 uc291ovt.2 
ENSMUST00000110221.10 Col14a1 ENSMUST00000110221.10 collagen, type XIV, alpha 1, transcript variant 2 (from RefSeq NM_181277.4) B7ZNH7 B7ZNH7_MOUSE Col14a1 ENSMUST00000110221.1 ENSMUST00000110221.2 ENSMUST00000110221.3 ENSMUST00000110221.4 ENSMUST00000110221.5 ENSMUST00000110221.6 ENSMUST00000110221.7 ENSMUST00000110221.8 ENSMUST00000110221.9 NM_181277 uc007vsc.1 uc007vsc.2 uc007vsc.3 uc007vsc.4 collagen trimer uc007vsc.1 uc007vsc.2 uc007vsc.3 uc007vsc.4 
ENSMUST00000110232.9 Adam33 ENSMUST00000110232.9 a disintegrin and metallopeptidase domain 33, transcript variant 3 (from RefSeq NR_136922.1) ADA33_MOUSE ENSMUST00000110232.1 ENSMUST00000110232.2 ENSMUST00000110232.3 ENSMUST00000110232.4 ENSMUST00000110232.5 ENSMUST00000110232.6 ENSMUST00000110232.7 ENSMUST00000110232.8 NR_136922 Q8R5G5 Q923W9 uc008mkm.1 uc008mkm.2 uc008mkm.3 uc008mkm.4 uc008mkm.5 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is widely expressed, most highly in the adult brain, heart, kidney, lung and testis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY382194.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q923W9-1; Sequence=Displayed; Name=2; IsoId=Q923W9-2; Sequence=VSP_005496; The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. metalloendopeptidase activity proteolysis peptidase activity metallopeptidase activity zinc ion binding membrane integral component of membrane hydrolase activity regulation of cytokine biosynthetic process regulation of cell proliferation metal ion binding uc008mkm.1 uc008mkm.2 uc008mkm.3 uc008mkm.4 uc008mkm.5 
ENSMUST00000110249.3 Prox2 ENSMUST00000110249.3 prospero homeobox 2, transcript variant 1 (from RefSeq NM_175198.6) ENSMUST00000110249.1 ENSMUST00000110249.2 NM_175198 PROX2_MOUSE Q8BII1 uc033ged.1 uc033ged.2 Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival. Nucleus Expressed in testis. Expressed in the developing nervous system. Expressed at 9.5 dpc in the geniculate (VIIth), petrosal (IXth), and nodose (Xth) ganglia. Expressed in postnatal eyes. The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain. Mice grow normally and body weight was similar to that of wild type. Heterozygous mutant mice survived to adulthood and appeared normal. Belongs to the Prospero homeodomain family. negative regulation of transcription from RNA polymerase II promoter lymphangiogenesis DNA binding nucleus regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lymphatic endothelial cell differentiation lens fiber cell morphogenesis uc033ged.1 uc033ged.2 
ENSMUST00000110259.8 Marchf1 ENSMUST00000110259.8 membrane associated ring-CH-type finger 1, transcript variant 3 (from RefSeq NM_175188.5) ENSMUST00000110259.1 ENSMUST00000110259.2 ENSMUST00000110259.3 ENSMUST00000110259.4 ENSMUST00000110259.5 ENSMUST00000110259.6 ENSMUST00000110259.7 MARH1_MOUSE March1 NM_175188 Q3U7M8 Q3UVF8 Q6NZQ8 Q8C294 Q8CBA1 uc009lvl.1 uc009lvl.2 uc009lvl.3 uc009lvl.4 E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Cytoplasmic vesicle membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q6NZQ8-1; Sequence=Displayed; Name=2; IsoId=Q6NZQ8-2; Sequence=VSP_022726; Name=3; IsoId=Q6NZQ8-3; Sequence=VSP_022727; Name=4; IsoId=Q6NZQ8-4; Sequence=VSP_022726, VSP_022728; Name=5; IsoId=Q6NZQ8-5; Sequence=VSP_022728; The RING-CH-type zinc finger domain is required for E3 ligase activity. Has a short half-life. Instability/short half-life permits rapid changes that allow efficient induction of antigen presentation once antigen presenting cells, APCs, receive maturation signals. Small changes in protein levels significantly alter the cell surface display of MHC class II proteins. Shows increase in the cell surface expression or half-life of MHC class II. Null cells have accumulated MHC class II and CD86 at the cell surface and a low antigen-presenting ability for exogenous antigens, in conventional dendritic cells (PubMed:19917682). Null cells have high antigen-presenting ability for exogenous antigens in B-cells (PubMed:17255932). protein polyubiquitination immune system process antigen processing and presentation of peptide antigen via MHC class II ubiquitin-protein transferase activity lysosome lysosomal membrane endosome endoplasmic reticulum membrane Golgi apparatus plasma membrane immune response zinc ion binding membrane integral component of membrane protein ubiquitination transferase activity cytoplasmic vesicle membrane cytoplasmic vesicle early endosome membrane late endosome membrane trans-Golgi network membrane MHC protein binding metal ion binding ubiquitin protein ligase activity uc009lvl.1 uc009lvl.2 uc009lvl.3 uc009lvl.4 
ENSMUST00000110262.3 Fastkd5 ENSMUST00000110262.3 FAST kinase domains 5, transcript variant 1 (from RefSeq NM_198176.3) ENSMUST00000110262.1 ENSMUST00000110262.2 FAKD5_MOUSE Kiaa1792 NM_198176 Q3UNY5 Q5DTV0 Q7TMV3 uc290anf.1 uc290anf.2 uc290anf.3 Plays an important role in the processing of non-canonical mitochondrial mRNA precursors. Found in a complex with GRSF1, DDX28, DHX30 and FASTKD2. Associates with the 12S mitochondrial rRNA (12S mt-rRNA). Mitochondrion matrix, mitochondrion nucleoid Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. Expression detected in spleen, testis, colon, heart, smooth muscle, kidney, brain, lung, liver, brown and white adipose tissue. Belongs to the FAST kinase family. Sequence=BAD90466.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE25612.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; mitochondrial RNA processing RNA binding protein kinase activity mitochondrion mRNA processing protein phosphorylation rRNA binding ribonucleoprotein granule mitochondrial nucleoid uc290anf.1 uc290anf.2 uc290anf.3 
ENSMUST00000110267.9 Sybu ENSMUST00000110267.9 syntabulin (syntaxin-interacting), transcript variant c (from RefSeq NM_178765.4) ENSMUST00000110267.1 ENSMUST00000110267.2 ENSMUST00000110267.3 ENSMUST00000110267.4 ENSMUST00000110267.5 ENSMUST00000110267.6 ENSMUST00000110267.7 ENSMUST00000110267.8 Golsyn Kiaa1472 NM_178765 Q3TQN7 Q401F3 Q401F4 Q571C1 Q6P1J2 Q80XH0 Q8BHS7 Q8BHS8 Q8BI27 SYBU_MOUSE uc007vqe.1 uc007vqe.2 uc007vqe.3 Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. Interacts with STX1A and KIF5B. Golgi apparatus membrane ; Single- pass membrane protein Note=Colocalizes with syntaxin vesicles along microtubules in neuronal processes. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8BHS8-1; Sequence=Displayed; Name=2; IsoId=Q8BHS8-2; Sequence=VSP_019727; Name=3; Synonyms=Golsyn B; IsoId=Q8BHS8-3; Sequence=VSP_019725, VSP_019728; Name=4; Synonyms=Golsyn A; IsoId=Q8BHS8-4; Sequence=VSP_019726; Name=5; IsoId=Q8BHS8-5; Sequence=VSP_019724; Name=6; IsoId=Q8BHS8-6; Sequence=VSP_019723; Sequence=BAD90193.1; Type=Erroneous initiation; Evidence=; Golgi membrane Golgi apparatus microtubule microtubule binding membrane integral component of membrane syntaxin-1 binding kinesin binding axonal transport of mitochondrion vesicle positive regulation of insulin secretion involved in cellular response to glucose stimulus intracellular membrane-bounded organelle regulation of synaptic activity synapse maturation regulation of insulin secretion involved in cellular response to glucose stimulus dense body axon cytoplasm anterograde neuronal dense core vesicle transport uc007vqe.1 uc007vqe.2 uc007vqe.3 
ENSMUST00000110272.9 Entpd5 ENSMUST00000110272.9 ectonucleoside triphosphate diphosphohydrolase 5, transcript variant 2 (from RefSeq NM_001026214.2) Cd39l4 ENSMUST00000110272.1 ENSMUST00000110272.2 ENSMUST00000110272.3 ENSMUST00000110272.4 ENSMUST00000110272.5 ENSMUST00000110272.6 ENSMUST00000110272.7 ENSMUST00000110272.8 ENTP5_MOUSE NM_001026214 O70214 Q544J4 Q8BR23 Q8CD29 Q9WUZ9 uc007ofg.1 uc007ofg.2 uc007ofg.3 uc007ofg.4 Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:10369669, PubMed:21074248). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP- glucose (PubMed:21074248). Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose (PubMed:21074248). Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (PubMed:21074248). Reaction=a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'- phosphate + H(+) + phosphate; Xref=Rhea:RHEA:36799, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:58043; EC=3.6.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36800; Evidence=; Reaction=GDP + H2O = GMP + H(+) + phosphate; Xref=Rhea:RHEA:22156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189; EC=3.6.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22157; Evidence=; Reaction=H2O + UDP = H(+) + phosphate + UMP; Xref=Rhea:RHEA:64876, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57865, ChEBI:CHEBI:58223; EC=3.6.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64877; Evidence=; Reaction=H2O + IDP = H(+) + IMP + phosphate; Xref=Rhea:RHEA:35207, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58053, ChEBI:CHEBI:58280; EC=3.6.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35208; Evidence=; Reaction=CDP + H2O = CMP + H(+) + phosphate; Xref=Rhea:RHEA:64880, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377; EC=3.6.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64881; Evidence=; Reaction=ADP + H2O = AMP + H(+) + phosphate; Xref=Rhea:RHEA:61436, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=3.6.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61437; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; pH dependence: Optimum pH is 7. ; Protein modification; protein glycosylation. Monomer; active form. Homodimer; disulfide-linked. Homodimers are enzymatically inactive. Endoplasmic reticulum Secreted Ubiquitous. Expressed in response to phosphoinositide 3-kinase (PI3K) signaling. Activation of PI3K results in FOXO phosphorylation by AKT1 and loss of ENTPD5 transcriptional repression. Up-regulated in PTEN- deficient cells. N-glycosylated; high-mannose type. Mice display hepatopathy and aspermia. The hepatopathy is progressive and characterized by centrilobular hepatocyte hypertrophy, oval cell proliferation, bile staining of Kupffer cells, and hepatocyte degeneration with increasing incidence and severity of degenerative lesions, development of multiple foci of cellular alteration, and hepatocellular neoplasia with age. Belongs to the GDA1/CD39 NTPase family. guanosine-diphosphatase activity extracellular region endoplasmic reticulum protein glycosylation protein N-linked glycosylation cell proliferation regulation of phosphatidylinositol 3-kinase signaling hydrolase activity nucleoside-diphosphatase activity uridine-diphosphatase activity positive regulation of glycolytic process ATP metabolic process 'de novo' posttranslational protein folding uc007ofg.1 uc007ofg.2 uc007ofg.3 uc007ofg.4 
ENSMUST00000110275.8 Serpinb6e ENSMUST00000110275.8 serine (or cysteine) peptidase inhibitor, clade B, member 6e (from RefSeq NM_001045535.2) ENSMUST00000110275.1 ENSMUST00000110275.2 ENSMUST00000110275.3 ENSMUST00000110275.4 ENSMUST00000110275.5 ENSMUST00000110275.6 ENSMUST00000110275.7 I7HJI3 I7HJI3_MOUSE NM_001045535 Serpinb6e uc007qal.1 uc007qal.2 Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular space cytoplasm negative regulation of endopeptidase activity uc007qal.1 uc007qal.2 
ENSMUST00000110276.8 Coq6 ENSMUST00000110276.8 FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (from UniProt Q8R1S0) BC088736 COQ6_MOUSE Coq6 ENSMUST00000110276.1 ENSMUST00000110276.2 ENSMUST00000110276.3 ENSMUST00000110276.4 ENSMUST00000110276.5 ENSMUST00000110276.6 ENSMUST00000110276.7 Q3TJM2 Q80V13 Q8BJY5 Q8R1S0 uc288huu.1 uc288huu.2 FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. Reaction=4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans- hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:20361, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:58373, ChEBI:CHEBI:84492; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Cofactor biosynthesis; ubiquinone biosynthesis. Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with COQ8B and COQ7. Mitochondrion inner membrane eripheral membrane protein atrix side Golgi apparatus ll projection te=Localizes to cell processes and Golgi apparatus in podocytes. Expressed in the kidney, in podocytes. At 12.5 dpc, expressed in the metanephric mesenchyme. At 16.5 dpc, expressed in the condensing metanephric mesenchyme surrounding the ureter tips. At 18.5 dpc, expressed in whole kidney. Belongs to the UbiH/COQ6 family. monooxygenase activity mitochondrion mitochondrial inner membrane Golgi apparatus ubiquinone biosynthetic process membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen extrinsic component of mitochondrial inner membrane cell projection flavin adenine dinucleotide binding oxidation-reduction process FAD binding uc288huu.1 uc288huu.2 
ENSMUST00000110281.2 1700020A23Rik ENSMUST00000110281.2 RIKEN cDNA 1700020A23 gene, transcript variant 2 (from RefSeq NM_029375.1) 1700020A23Rik ENSMUST00000110281.1 NM_029375 Q9DA59 Q9DA59_MOUSE uc012cee.1 uc012cee.2 uc012cee.3 molecular_function cellular_component biological_process membrane integral component of membrane uc012cee.1 uc012cee.2 uc012cee.3 
ENSMUST00000110286.8 Ebf4 ENSMUST00000110286.8 early B cell factor 4, transcript variant 2 (from RefSeq NM_001110513.1) A2BI82 A2BI83 COE4_MOUSE Coe4 ENSMUST00000110286.1 ENSMUST00000110286.2 ENSMUST00000110286.3 ENSMUST00000110286.4 ENSMUST00000110286.5 ENSMUST00000110286.6 ENSMUST00000110286.7 NM_001110513 Q8K4J1 Q8K4J2 Q8K4J3 Q8K4J4 Q8K4J5 uc008miq.1 uc008miq.2 uc008miq.3 Transcription factor (PubMed:12139918). Positively modulates transcription, perhaps less strongly than other early B cell factor/EBF family proteins (PubMed:12139918). Binds an EBF1/Olf-1 consensus site in vitro (PubMed:12139918). Forms either a homodimer or a heterodimer with a related family member. Nucleus Event=Alternative splicing; Named isoforms=5; Name=3; Synonyms=4-23; IsoId=Q8K4J2-1; Sequence=Displayed; Name=1; Synonyms=4-11; IsoId=Q8K4J2-2; Sequence=VSP_001125, VSP_001126; Name=2; Synonyms=4-14; IsoId=Q8K4J2-3; Sequence=VSP_001121, VSP_001122; Name=4; Synonyms=4-132; IsoId=Q8K4J2-4; Sequence=VSP_001123, VSP_001124; Name=5; Synonyms=4S; IsoId=Q8K4J2-5; Sequence=VSP_001119, VSP_001120; Expressed in the olfactory epithelium, including in both neuronal and basal cell layers (PubMed:12139918, PubMed:35939714). Absent in the vomeronasal organ (PubMed:12139918). Absent from NK cells and CD8(+) T cells (PubMed:35939714). Apparently no differences in the NK, CD8(+), and CD4(+) precursor and mature cell subsets in the thymus, spleen, or liver. [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the COE family. EBF4 is expressed in human NK cells and CD8(+) T-cells (PubMed:35939714). It has been suggested, therefore, that the functions of EBF4 differ between humans and mice (PubMed:35939714). RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development transcription factor binding positive regulation of transcription from RNA polymerase II promoter metal ion binding protein dimerization activity uc008miq.1 uc008miq.2 uc008miq.3 
ENSMUST00000110293.9 Serpinb6b ENSMUST00000110293.9 serine (or cysteine) peptidase inhibitor, clade B, member 6b (from RefSeq NM_011454.2) ENSMUST00000110293.1 ENSMUST00000110293.2 ENSMUST00000110293.3 ENSMUST00000110293.4 ENSMUST00000110293.5 ENSMUST00000110293.6 ENSMUST00000110293.7 ENSMUST00000110293.8 NM_011454 O08804 O08804_MOUSE Serpinb6b uc007pzx.1 uc007pzx.2 uc007pzx.3 Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular space nucleus cytoplasm gonad development negative regulation of endopeptidase activity uc007pzx.1 uc007pzx.2 uc007pzx.3 
ENSMUST00000110299.3 Tgm3 ENSMUST00000110299.3 transglutaminase 3, E polypeptide, transcript variant 1 (from RefSeq NM_009374.4) A1L343 A2ANC3 ENSMUST00000110299.1 ENSMUST00000110299.2 NM_009374 Q08189 TGM3_MOUSE Tgase3 uc008mig.1 uc008mig.2 uc008mig.3 uc008mig.4 Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. Reaction=L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L- lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:54816, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:14005, ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:30011, ChEBI:CHEBI:138370; EC=2.3.2.13; Evidence= Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) cations per subunit. Binds 1 Ca(2+) as a zymogen, and binds 2 more Ca(2+) cations, or other divalent metal cations, after proteolytic processing. ; Consists of two polypeptide chains, which are synthesized as a precursor form of a single polypeptide. Cytoplasm Expressed in skin and stomach and, at lower levels, in testis, kidney and spleen (at protein level). On the basis of its catalytic activity, detected in the epidermis, around the granular and spinous layers but not in the outermost cornified layers. In hair follicles, mainly located in the medulla and the hair cortex. Expression starts at 11.5 dpc in the early two- layered epidermis. From 12.5 dpc, mainly expressed in the periderm cells and weakly in the epidermal basal cells. After epidermis keratinization, at 15.5 to 17.5 dpc, detected in the granular, cornified layers and in the hair follicle. Also expressed in heart, lung, bone, muscle, testis and blood vessels at 12.5, 13.5, 14.5 and 16.5 dpc, respectively. Activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Physiological activation may be catalyzed by CTSL and, to a lesser extent, by CTSS (By similarity). Belongs to the transglutaminase superfamily. Transglutaminase family. Sequence=AAA40421.1; Type=Frameshift; Evidence=; cornified envelope protein-glutamine gamma-glutamyltransferase activity catalytic activity calcium ion binding cytoplasm epidermis development transferase activity transferase activity, transferring acyl groups peptide cross-linking keratinocyte differentiation extrinsic component of cytoplasmic side of plasma membrane keratinization hair cell differentiation cell envelope organization skin development metal ion binding protein tetramerization uc008mig.1 uc008mig.2 uc008mig.3 uc008mig.4 
ENSMUST00000110307.3 Irf4 ENSMUST00000110307.3 interferon regulatory factor 4, transcript variant 2 (from RefSeq NM_001347508.1) ENSMUST00000110307.1 ENSMUST00000110307.2 IRF4_MOUSE NM_001347508 Q60802 Q64287 Spip uc007pza.1 uc007pza.2 uc007pza.3 Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA- 3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. Interacts with SPIB and DEF6 (By similarity). Interacts with the BATF-JUNB heterodimer. Interacts with BATF (via bZIP domain); the interaction is direct. Directly interacts with NLRP3 in the nucleus of Th2 cells; this interaction enhances IRF4 ability to bind to the IL4 promoter and is required for optimal IRF4-dependent IL4 transcription (PubMed:26098997). Interacts with SPI1 (By similarity). Q64287; O35284: Batf; NbExp=7; IntAct=EBI-6398485, EBI-6398523; Q64287; O70343: Ppargc1a; NbExp=6; IntAct=EBI-6398485, EBI-1371053; Nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q64287-1; Sequence=Displayed; Name=2; IsoId=Q64287-2; Sequence=VSP_002756; Lymphoid cells. Not induced by interferons. Phosphorylation by ROCK2 regulates IL-17 and IL-21 production. Belongs to the IRF family. nuclear nucleosome RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding immune system process DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated negative regulation of toll-like receptor signaling pathway defense response to protozoan myeloid dendritic cell differentiation positive regulation of DNA binding sequence-specific DNA binding histone H3 acetylation histone H4 acetylation transcription regulatory region DNA binding positive regulation of interleukin-10 biosynthetic process positive regulation of interleukin-2 biosynthetic process positive regulation of interleukin-13 biosynthetic process positive regulation of interleukin-4 biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter T-helper 17 cell lineage commitment uc007pza.1 uc007pza.2 uc007pza.3 
ENSMUST00000110320.9 Zc3h6 ENSMUST00000110320.9 zinc finger CCCH type containing 6 (from RefSeq NM_178404.3) A2AP88 A2AP88_MOUSE ENSMUST00000110320.1 ENSMUST00000110320.2 ENSMUST00000110320.3 ENSMUST00000110320.4 ENSMUST00000110320.5 ENSMUST00000110320.6 ENSMUST00000110320.7 ENSMUST00000110320.8 NM_178404 Zc3h6 uc008mhc.1 uc008mhc.2 uc008mhc.3 metal ion binding uc008mhc.1 uc008mhc.2 uc008mhc.3 
ENSMUST00000110324.8 Fbln7 ENSMUST00000110324.8 An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation. (from UniProt Q501P1) AK005465 ENSMUST00000110324.1 ENSMUST00000110324.2 ENSMUST00000110324.3 ENSMUST00000110324.4 ENSMUST00000110324.5 ENSMUST00000110324.6 ENSMUST00000110324.7 FBLN7_MOUSE Q501P1 Q9DAW5 Tm14 uc008mgy.1 uc008mgy.2 uc008mgy.3 An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation. Interacts with heparin, FBLN1, FN1 and DSPP. Preferentially binds dental mesenchyme cells and odontoblasts but not dental epithelial cells or nondental cells. Binding requires a heparan sulfate-containing receptor on the cell surface as well as an integrin. Secreted, extracellular space, extracellular matrix. Highly expressed in newborn incisors and molars. A weaker expression is seen in the brain, kidneys, muscles and bones. Expressed by preodontoblasts and odontoblasts in developing teeth. Localizes to the apical pericellular regions of preodontoblasts. When the dentin matrix is fully formed and dentin mineralization occurs, it is present in the predentin matrix and along the dentinal tubules. It is also expressed in the developing growth plate cartilage, hair follicles and extraembryonic areas of the placenta. N-glycosylated. Belongs to the fibulin family. Sequence=ABU48629.1; Type=Frameshift; Evidence=; Sequence=BAB24056.1; Type=Frameshift; Evidence=; calcium ion binding extracellular region cell adhesion heparin binding uc008mgy.1 uc008mgy.2 uc008mgy.3 
ENSMUST00000110325.8 Tmem87b ENSMUST00000110325.8 transmembrane protein 87B, transcript variant 2 (from RefSeq NM_028248.2) A2AN76 ENSMUST00000110325.1 ENSMUST00000110325.2 ENSMUST00000110325.3 ENSMUST00000110325.4 ENSMUST00000110325.5 ENSMUST00000110325.6 ENSMUST00000110325.7 NM_028248 Q3T9D2 Q8BKU8 Q8K0G0 Q9D001 TM87B_MOUSE Tmem87b uc008mgx.1 uc008mgx.2 uc008mgx.3 May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). Golgi apparatus membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BKU8-1; Sequence=Displayed; Name=2; IsoId=Q8BKU8-2; Sequence=VSP_026220; Name=3; IsoId=Q8BKU8-3; Sequence=VSP_026221; Belongs to the LU7TM family. TMEM87 subfamily. Sequence=BAB27940.1; Type=Frameshift; Evidence=; Golgi membrane molecular_function Golgi apparatus cytosol membrane integral component of membrane retrograde transport, endosome to Golgi uc008mgx.1 uc008mgx.2 uc008mgx.3 
ENSMUST00000110341.9 Bcl2l11 ENSMUST00000110341.9 BCL2 like 11, transcript variant 1 (from RefSeq NM_207680.2) Bcl2l11 ENSMUST00000110341.1 ENSMUST00000110341.2 ENSMUST00000110341.3 ENSMUST00000110341.4 ENSMUST00000110341.5 ENSMUST00000110341.6 ENSMUST00000110341.7 ENSMUST00000110341.8 NM_207680 Q542N5 Q542N5_MOUSE uc008mgm.1 uc008mgm.2 uc008mgm.3 Induces apoptosis and anoikis. Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1. Belongs to the Bcl-2 family. B cell apoptotic process mitochondrion apoptotic process cell-matrix adhesion brain development intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of cell death membrane positive regulation of protein complex assembly autophagy in response to ER overload response to endoplasmic reticulum stress positive regulation of apoptotic process cellular response to estradiol stimulus positive regulation of release of cytochrome c from mitochondria cellular response to beta-amyloid positive regulation of fibroblast apoptotic process uc008mgm.1 uc008mgm.2 uc008mgm.3 
ENSMUST00000110366.8 Zfp661 ENSMUST00000110366.8 zinc finger protein 661, transcript variant 3 (from RefSeq NM_001355622.1) ENSMUST00000110366.1 ENSMUST00000110366.2 ENSMUST00000110366.3 ENSMUST00000110366.4 ENSMUST00000110366.5 ENSMUST00000110366.6 ENSMUST00000110366.7 NM_001355622 Q7TPW3 Q8BIQ3 ZNF2_MOUSE Znf2 uc290agq.1 uc290agq.2 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc290agq.1 uc290agq.2 
ENSMUST00000110369.10 Prl ENSMUST00000110369.10 prolactin, transcript variant 1 (from RefSeq NM_011164.2) ENSMUST00000110369.1 ENSMUST00000110369.2 ENSMUST00000110369.3 ENSMUST00000110369.4 ENSMUST00000110369.5 ENSMUST00000110369.6 ENSMUST00000110369.7 ENSMUST00000110369.8 ENSMUST00000110369.9 Gha1 NM_011164 Prl Q9CPQ2 Q9CPQ2_MOUSE uc007pxb.1 uc007pxb.2 uc007pxb.3 uc007pxb.4 Prolactin acts primarily on the mammary gland by promoting lactation. Interacts with PRLR. Secreted Belongs to the somatotropin/prolactin family. hormone activity extracellular region signal transduction parturition response to nutrient circadian rhythm positive regulation of cell proliferation response to organic cyclic compound secretory granule regulation of ossification response to estradiol response to lipopolysaccharide cellular response to hormone stimulus multicellular organismal response to stress response to drug ovulation cycle response to ethanol positive regulation of epithelial cell proliferation uc007pxb.1 uc007pxb.2 uc007pxb.3 uc007pxb.4 
ENSMUST00000110375.9 Stard7 ENSMUST00000110375.9 StAR related lipid transfer domain containing 7, transcript variant 4 (from RefSeq NR_188880.1) A2ARG0 ENSMUST00000110375.1 ENSMUST00000110375.2 ENSMUST00000110375.3 ENSMUST00000110375.4 ENSMUST00000110375.5 ENSMUST00000110375.6 ENSMUST00000110375.7 ENSMUST00000110375.8 NR_188880 Q8R1R3 STAR7_MOUSE uc008mfe.1 uc008mfe.2 uc008mfe.3 uc008mfe.4 May play a protective role in mucosal tissues by preventing exaggerated allergic responses. Mitochondrion Expressed in epithelial cells of airways, peripheral bronchioles and alveoli, as well as in the basal cell layer of the epidermis (at protein level). Proteolytically cleaved by PARL. The viability of homozygous knockout embryos is dramatically decreased after 10.0 dpc. Surviving animals have a normal life expectancy, but males are infertile. Ovalbumin sensitization and challenge of heterozygous mice results in a significant increase in pulmonary inflammation, mucous cell metaplasia, airway hyperresponsiveness and ovalbumin-specific IgE compared with wild-type animals. This exacerbation is associated with an increase in CD4(+) IL13(+) T helper cells, as well as an increase IL4, IL5 and IL13 cytokine production in lungs. Sensitized and/or challenged mutant animals show an increased lung epithelial permeability and activation of pro-inflammatory dendritic cells. At 6-7 months of age, about 30% of heterozygous mice develop skin lesions, with significant thickening of the epidermis, including the cornified layer, predominately on the ears and back. Lesions are accompanied by vigorous scratching. In the lesions, IL4, IL5 and IL13 cytokine production is increased and serum IgE levels are up-regulated at the time of appearance of skin lesions. cellular_component mitochondrion lipid binding uc008mfe.1 uc008mfe.2 uc008mfe.3 uc008mfe.4 
ENSMUST00000110380.8 Lrp2bp ENSMUST00000110380.8 May act as an adapter that regulates LRP2 function. (from UniProt Q9D4C6) AK016626 ENSMUST00000110380.1 ENSMUST00000110380.2 ENSMUST00000110380.3 ENSMUST00000110380.4 ENSMUST00000110380.5 ENSMUST00000110380.6 ENSMUST00000110380.7 LR2BP_MOUSE Q3UV46 Q8CF18 Q8K0N7 Q9D4C6 uc291zqu.1 uc291zqu.2 May act as an adapter that regulates LRP2 function. Interacts with LRP2. Cytoplasm Note=Detected in a vesicular staining pattern close to the plasma membrane and throughout the cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D4C6-1; Sequence=Displayed; Name=2; IsoId=Q9D4C6-2; Sequence=VSP_030665; Sequence=BAC25168.1; Type=Frameshift; Evidence=; protein binding cytoplasm biological_process uc291zqu.1 uc291zqu.2 
ENSMUST00000110382.9 Gmnn ENSMUST00000110382.9 geminin (from RefSeq NM_020567.2) ENSMUST00000110382.1 ENSMUST00000110382.2 ENSMUST00000110382.3 ENSMUST00000110382.4 ENSMUST00000110382.5 ENSMUST00000110382.6 ENSMUST00000110382.7 ENSMUST00000110382.8 Gmnn NM_020567 Q3V295 Q3V295_MOUSE uc007pwh.1 uc007pwh.2 uc007pwh.3 Nucleus Belongs to the geminin family. chromatin binding nucleus cytoplasm cytosol regulation of DNA replication negative regulation of DNA replication positive regulation of chromatin binding histone deacetylase binding negative regulation of cell cycle negative regulation of transcription, DNA-templated DNA replication preinitiation complex assembly negative regulation of DNA-dependent DNA replication uc007pwh.1 uc007pwh.2 uc007pwh.3 
ENSMUST00000110386.2 Itpripl1 ENSMUST00000110386.2 inositol 1,4,5-triphosphate receptor interacting protein-like 1, transcript variant 1 (from RefSeq NM_001163527.1) A1L3P2 A2ASA8 B7ZCY2 ENSMUST00000110386.1 IPIL1_MOUSE NM_001163527 uc033hpy.1 uc033hpy.2 uc033hpy.3 Membrane ; Single-pass type I membrane protein Belongs to the ITPRIP family. molecular_function biological_process membrane integral component of membrane uc033hpy.1 uc033hpy.2 uc033hpy.3 
ENSMUST00000110387.4 Ncaph ENSMUST00000110387.4 non-SMC condensin I complex, subunit H (from RefSeq NM_144818.4) Brrn Brrn1 CND2_MOUSE Caph ENSMUST00000110387.1 ENSMUST00000110387.2 ENSMUST00000110387.3 NM_144818 Q8BY01 Q8C156 Q8VDM9 uc008met.1 uc008met.2 uc008met.3 uc008met.4 Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Nucleus Cytoplasm Chromosome Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase (By similarity). Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity). Belongs to the CND2 (condensin subunit 2) family. Sequence=AAH21499.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH25060.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC31339.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; condensin complex nuclear condensin complex chromatin binding nucleus chromosome cytoplasm cytosol cell cycle mitotic chromosome condensation female meiotic division meiotic chromosome condensation chromosome condensation DNA topoisomerase binding meiotic chromosome segregation cell division female meiosis chromosome separation DNA topoisomerase (ATP-hydrolyzing) activator activity positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity uc008met.1 uc008met.2 uc008met.3 uc008met.4 
ENSMUST00000110388.10 Gphn ENSMUST00000110388.10 gephyrin, transcript variant 1 (from RefSeq NM_145965.2) A0JNY3 A0JNY3_MOUSE ENSMUST00000110388.1 ENSMUST00000110388.2 ENSMUST00000110388.3 ENSMUST00000110388.4 ENSMUST00000110388.5 ENSMUST00000110388.6 ENSMUST00000110388.7 ENSMUST00000110388.8 ENSMUST00000110388.9 Gphn NM_145965 uc007nzd.1 uc007nzd.2 uc007nzd.3 uc007nzd.4 uc007nzd.5 Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. Reaction=ATP + H(+) + molybdopterin = adenylyl-molybdopterin + diphosphate; Xref=Rhea:RHEA:31331, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58698, ChEBI:CHEBI:62727; Evidence=; Reaction=adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo- molybdopterin; Xref=Rhea:RHEA:35047, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:36264, ChEBI:CHEBI:62727, ChEBI:CHEBI:71302, ChEBI:CHEBI:456215; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cofactor biosynthesis; molybdopterin biosynthesis. Belongs to the MoeA family. In the C-terminal section; belongs to the MoeA family. In the N-terminal section; belongs to the MoaB/Mog family. ATP binding Mo-molybdopterin cofactor biosynthetic process nitrate reductase activity response to metal ion transferase activity dendrite molybdopterin cofactor biosynthetic process molybdopterin cofactor binding postsynaptic membrane metal ion binding oxidation-reduction process molybdopterin adenylyltransferase activity molybdopterin molybdotransferase activity gamma-aminobutyric acid receptor clustering uc007nzd.1 uc007nzd.2 uc007nzd.3 uc007nzd.4 uc007nzd.5 
ENSMUST00000110395.11 Max ENSMUST00000110395.11 Max protein, transcript variant 1 (from RefSeq NM_008558.3) B2RS19 ENSMUST00000110395.1 ENSMUST00000110395.10 ENSMUST00000110395.2 ENSMUST00000110395.3 ENSMUST00000110395.4 ENSMUST00000110395.5 ENSMUST00000110395.6 ENSMUST00000110395.7 ENSMUST00000110395.8 ENSMUST00000110395.9 MAX_MOUSE Max Myn NM_008558 P28574 Q8C4Y1 uc007nyw.1 uc007nyw.2 uc007nyw.3 uc007nyw.4 Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. CpG methylation of the recognition site greatly inhibits DNA binding, suggesting that DNA methylation may regulate the MYC:MAX complex in vivo. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. P28574; Q9QWV9: Ccnt1; NbExp=2; IntAct=EBI-1183003, EBI-2655009; P28574; Q99J95: Cdk9; NbExp=2; IntAct=EBI-1183003, EBI-2654963; P28574; P01108: Myc; NbExp=7; IntAct=EBI-1183003, EBI-1183114; Nucleus. Cell projection, dendrite Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P28574-1; Sequence=Displayed; Name=2; IsoId=P28574-2; Sequence=VSP_059578; By serum; in 3T3 fibroblasts. Phosphorylated. Belongs to the MAX family. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cellular response to starvation response to organonitrogen compound negative regulation of gene expression PML body dendrite response to insulin protein-DNA complex protein homodimerization activity cell projection sequence-specific DNA binding macromolecular complex binding positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity response to axon injury neuron apoptotic process retina development in camera-type eye macromolecular complex assembly E-box binding MLL1 complex cellular response to peptide hormone stimulus RNA polymerase II transcription factor complex uc007nyw.1 uc007nyw.2 uc007nyw.3 uc007nyw.4 
ENSMUST00000110408.3 Ropn1l ENSMUST00000110408.3 ropporin 1-like (from RefSeq NM_145852.2) Asp ENSMUST00000110408.1 ENSMUST00000110408.2 NM_145852 Q6P8Z9 Q9EQ00 ROP1L_MOUSE uc007vkg.1 uc007vkg.2 uc007vkg.3 Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (PubMed:36417862). Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Component of the axonemal radial spoke complex 1 (RS1), at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB (PubMed:36417862). May interact with AKAP3 (By similarity). Interacts with FSCB; the interaction increases upon spermatozoa capacitation conditions (PubMed:27398160). Cell projection, cilium, flagellum Cell projection, cilium Testis-specific. Expression is restricted to germ cells. Expressed in testis at least from P5 to P40. Expression increases with sample age. Detected in the flagella of elongated spermatids, but the expression levels reduce as the sperm matures (heads move towards the center lumen) (PubMed:23303679). Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions. Mutant mice have normal testicular morphology and spermatogenesis but have moderately impaired motility and increased levels of ROPN1 (PubMed:23303679). Double knockout animals for ROPN1 and ROPN1L are infertile with normal testicular morphology and spermatogenesis but defects in sperm morphology, thinning and shredding of the principal piece. Sperm is immotile (PubMed:23303679). Belongs to the ropporin family. Sequence=AAG40851.1; Type=Frameshift; Evidence=; regulation of protein phosphorylation cilium movement protein binding cytoplasm cilium flagellated sperm motility motile cilium cell projection sperm capacitation uc007vkg.1 uc007vkg.2 uc007vkg.3 
ENSMUST00000110410.10 Ankrd33b ENSMUST00000110410.10 ankyrin repeat domain 33B, transcript variant 2 (from RefSeq NM_027496.3) AN33B_MOUSE ENSMUST00000110410.1 ENSMUST00000110410.2 ENSMUST00000110410.3 ENSMUST00000110410.4 ENSMUST00000110410.5 ENSMUST00000110410.6 ENSMUST00000110410.7 ENSMUST00000110410.8 ENSMUST00000110410.9 NM_027496 Q3U0L2 Q8BJA8 Q9CYB2 Q9CZ88 Q9DCQ8 uc007vke.1 uc007vke.2 uc007vke.3 uc007vke.4 uc007vke.5 Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3U0L2-1; Sequence=Displayed; Name=2; IsoId=Q3U0L2-2; Sequence=VSP_032778; Name=3; IsoId=Q3U0L2-3; Sequence=VSP_032781, VSP_032782; Name=4; IsoId=Q3U0L2-4; Sequence=VSP_032779, VSP_032780; molecular_function DNA binding cellular_component biological_process uc007vke.1 uc007vke.2 uc007vke.3 uc007vke.4 uc007vke.5 
ENSMUST00000110411.4 Adam34 ENSMUST00000110411.4 predicted gene 5347 (from RefSeq NM_001079931.2) A2RSG8 A2RSG8_MOUSE Adam34 ENSMUST00000110411.1 ENSMUST00000110411.2 ENSMUST00000110411.3 NM_001079931 uc009loh.1 uc009loh.2 uc009loh.3 uc009loh.4 Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function metalloendopeptidase activity cellular_component proteolysis integrin-mediated signaling pathway biological_process metallopeptidase activity membrane integral component of membrane uc009loh.1 uc009loh.2 uc009loh.3 uc009loh.4 
ENSMUST00000110413.8 Slc17a1 ENSMUST00000110413.8 solute carrier family 17 (sodium phosphate), member 1, transcript variant 2 (from RefSeq NM_001170638.1) A9Z1Z4 ENSMUST00000110413.1 ENSMUST00000110413.2 ENSMUST00000110413.3 ENSMUST00000110413.4 ENSMUST00000110413.5 ENSMUST00000110413.6 ENSMUST00000110413.7 NM_001170638 NPT1_MOUSE Npt1 Q61983 Q91YA1 uc007pvf.1 uc007pvf.2 uc007pvf.3 uc007pvf.4 Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney. Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in); Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; Evidence=; Reaction=urate(out) = urate(in); Xref=Rhea:RHEA:60368, ChEBI:CHEBI:17775; Evidence=; Interacts with PDZK1. Apical cell membrane ; Multi-pass membrane protein Kidney. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. plasma membrane integral component of plasma membrane ion transport sodium ion transport phosphate ion transmembrane transporter activity symporter activity urate transport membrane integral component of membrane apical plasma membrane phosphate ion transmembrane transport urate metabolic process transmembrane transport uc007pvf.1 uc007pvf.2 uc007pvf.3 uc007pvf.4 
ENSMUST00000110433.10 Btn2a2 ENSMUST00000110433.10 butyrophilin, subfamily 2, member A2, transcript variant 1 (from RefSeq NM_175938.3) A4QPC6 BT2A2_MOUSE ENSMUST00000110433.1 ENSMUST00000110433.2 ENSMUST00000110433.3 ENSMUST00000110433.4 ENSMUST00000110433.5 ENSMUST00000110433.6 ENSMUST00000110433.7 ENSMUST00000110433.8 ENSMUST00000110433.9 NM_175938 Q811T8 uc007ptu.1 uc007ptu.2 uc007ptu.3 Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A4QPC6-1; Sequence=Displayed; Name=2; IsoId=A4QPC6-2; Sequence=VSP_036621, VSP_036622; Widely expressed (at protein level). In the thymus, restricted to the corticomedullary junction, but not confined solely to epithelial cells (at protein level). Significant expression on naive B- cells, splenic natural killer cells, dendritic cells and peritoneal macrophages (at protein level). Negligible expression on naive T-cells up-regulated on activated T-cells (at protein level). N-glycosylated. Belongs to the immunoglobulin superfamily. BTN/MOG family. receptor binding external side of plasma membrane cell surface negative regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane negative regulation of cellular metabolic process positive regulation of regulatory T cell differentiation negative regulation of activated T cell proliferation negative regulation of cytokine secretion regulation of immune response T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade negative regulation of G1/S transition of mitotic cell cycle uc007ptu.1 uc007ptu.2 uc007ptu.3 
ENSMUST00000110446.9 Fam227b ENSMUST00000110446.9 family with sequence similarity 227, member B (from RefSeq NM_029455.3) A2AR82 ENSMUST00000110446.1 ENSMUST00000110446.2 ENSMUST00000110446.3 ENSMUST00000110446.4 ENSMUST00000110446.5 ENSMUST00000110446.6 ENSMUST00000110446.7 ENSMUST00000110446.8 F227B_MOUSE NM_029455 Q9D518 uc012cde.1 uc012cde.2 uc012cde.3 Belongs to the FAM227 family. Sequence=BAB30022.1; Type=Miscellaneous discrepancy; Note=Intron retention. The sequence differs at its 3' end due to intron retention.; Evidence=; molecular_function cellular_component biological_process uc012cde.1 uc012cde.2 uc012cde.3 
ENSMUST00000110452.2 H2bc11 ENSMUST00000110452.2 H2B clustered histone 11 (from RefSeq NM_178198.3) ENSMUST00000110452.1 H2B1F_MOUSE H2b-f H2b-j H2b-l H2b-n H2bc11 H2bc13 H2bc15 H2bc7 Hist1h2bf Hist1h2bj Hist1h2bl Hist1h2bn NM_178198 P10853 Q5SZZ3 uc007pse.1 uc007pse.2 uc007pse.3 uc007pse.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: SRR7345562.3400019.1, SRR7345562.5018327.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome innate immune response in mucosa DNA binding extracellular space nucleus nucleoplasm chromosome cytosol nucleosome assembly antibacterial humoral response identical protein binding protein heterodimerization activity defense response to Gram-positive bacterium uc007pse.1 uc007pse.2 uc007pse.3 uc007pse.4 
ENSMUST00000110455.4 H2bc12 ENSMUST00000110455.4 H2B clustered histone 12 (from RefSeq NM_175665.2) ENSMUST00000110455.1 ENSMUST00000110455.2 ENSMUST00000110455.3 H2B1K_MOUSE H2bc12 Hist1h2bk NM_175665 Q8CGP1 uc007psb.1 uc007psb.2 uc007psb.3 uc007psb.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome innate immune response in mucosa DNA binding extracellular space nucleus nucleoplasm chromosome cytosol nucleosome assembly antibacterial humoral response killing of cells of other organism protein heterodimerization activity defense response to Gram-negative bacterium defense response to Gram-positive bacterium uc007psb.1 uc007psb.2 uc007psb.3 uc007psb.4 
ENSMUST00000110457.8 Myo10 ENSMUST00000110457.8 myosin X, transcript variant 1 (from RefSeq NM_019472.2) ENSMUST00000110457.1 ENSMUST00000110457.2 ENSMUST00000110457.3 ENSMUST00000110457.4 ENSMUST00000110457.5 ENSMUST00000110457.6 ENSMUST00000110457.7 F8VQB6 MYO10_MOUSE NM_019472 Q8R3S0 Q9JJY5 uc007vjc.1 uc007vjc.2 uc007vjc.3 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (By similarity). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5- trisphosphate or integrins, and mediates cargo transport along actin filaments (By similarity). Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion. Monomer, when in an inactive conformation in the cytosol. Homodimer in its active, membrane-bound conformation; antiparallel coiled coil-mediated dimer formation. Interacts with ECPAS. Interacts with DCC and ITGB5; the presence of DCC inhibits ITGB5 binding. Interacts with tubulin; ITGB5 or DCC binding inhibits tubulin binding. Interacts strongly with CALM3 and weakly with CALM, the CALM3 interaction is essential for function in filopodial extension and motility. Interacts with ITGB1, ITGB3 and ITGB5 (By similarity). Interacts with NEO1. Interacts with VASP. F8VQB6; P97798-1: Neo1; NbExp=2; IntAct=EBI-6445959, EBI-40201781; Cytoplasm, cytosol. Cell projection, lamellipodium Cell projection, ruffle Cytoplasm, cytoskeleton. Cell projection, filopodium tip. Cytoplasm, cell cortex. Cell projection, filopodium membrane; Peripheral membrane protein. Note=May be in an inactive, monomeric conformation in the cytosol. Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Interacts with microtubules. Undergoes forward and rearward movements within filopodia. Interaction with membranes containing phosphatidylinositol 3,4,5-trisphosphate mediates localization at filopodium membranes (By similarity). Event=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=240kDa, FL-myo10; IsoId=F8VQB6-1; Sequence=Displayed; Name=Headless; Synonyms=165kDa, Hdl-myo10; IsoId=F8VQB6-2; Sequence=VSP_054978; Detected in brain, heart, kidney, liver, stomach, skeletal muscle, lung, testis and skin. Isoform Headless is expressed in embryonic and neuronal stem cells, and enriched in proliferating and migrating cells. Interaction between the motor domain and the tail leads to an inactive, monomeric conformation. Phospholipid binding via the PH domains leads to the formation of the active, dimeric form of the protein and strongly increases actin-dependent ATPase activity and motor activity (By similarity). Interacts with membranes containing phosphatidylinositol-3,4,5- trisphosphate via the PH domains. IQ 3 domain mediates high-affinity calcium-dependent binding to CALM3/CLP. The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha- helical structure by ionic bonds (PubMed:16030012). It can refold after extension suggesting an in vivo force-dependent function (By similarity). An anti-parallel coiled coil is located C-terminal to the SAH domain and mediates dimerization (By similarity). The initiator methionine for isoform Headless is removed. [Isoform Headless]: Produced by alternative promoter usage. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents an unconventional myosin. This protein should not be confused with the conventional myosin-10 (MYH10). nucleotide binding ruffle motor activity actin binding protein binding calmodulin binding ATP binding phosphatidylinositol-3,4,5-trisphosphate binding nucleolus cytoplasm cytosol cytoskeleton plasma membrane cell cortex regulation of cell shape membrane myosin complex positive regulation of cell-cell adhesion lamellipodium filopodium spectrin binding cytoskeleton-dependent intracellular transport actin-dependent ATPase activity filopodium membrane filopodium tip cell projection neuron projection neuronal cell body cell motility actin filament binding regulation of filopodium assembly plus-end directed microfilament motor activity uc007vjc.1 uc007vjc.2 uc007vjc.3 
ENSMUST00000110483.9 Stard13 ENSMUST00000110483.9 StAR related lipid transfer domain containing 13, transcript variant 4 (from RefSeq NR_153382.2) E9PUB5 ENSMUST00000110483.1 ENSMUST00000110483.2 ENSMUST00000110483.3 ENSMUST00000110483.4 ENSMUST00000110483.5 ENSMUST00000110483.6 ENSMUST00000110483.7 ENSMUST00000110483.8 NR_153382 Q8K369 Q923Q2 STA13_MOUSE uc009aum.1 uc009aum.2 uc009aum.3 uc009aum.4 May function as a GTPase-activating protein. Homodimer. Interacts with TAX1BP1 (By similarity). Q923Q2; Q96QB1: DLC1; Xeno; NbExp=2; IntAct=EBI-8393503, EBI-2608428; Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet GTPase activator activity cytoplasm mitochondrion lipid particle cell cycle signal transduction lipid binding membrane mitochondrial membrane endothelial cell migration positive regulation of GTPase activity negative regulation of cell migration involved in sprouting angiogenesis endothelial tube lumen extension negative regulation of sprouting angiogenesis angiogenesis involved in wound healing uc009aum.1 uc009aum.2 uc009aum.3 uc009aum.4 
ENSMUST00000110485.3 Zscan26 ENSMUST00000110485.3 zinc finger and SCAN domain containing 26, transcript variant 8 (from RefSeq NM_001426348.1) ENSMUST00000110485.1 ENSMUST00000110485.2 NM_001426348 Q5RJ54 Q6NVD7 ZSC26_MOUSE Zfp187 Znf187 uc288les.1 uc288les.2 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5RJ54-1; Sequence=Displayed; Name=2; IsoId=Q5RJ54-2; Sequence=VSP_028703; nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated metal ion binding uc288les.1 uc288les.2 
ENSMUST00000110491.9 Gpx5 ENSMUST00000110491.9 glutathione peroxidase 5 (from RefSeq NM_010343.2) E9QK84 ENSMUST00000110491.1 ENSMUST00000110491.2 ENSMUST00000110491.3 ENSMUST00000110491.4 ENSMUST00000110491.5 ENSMUST00000110491.6 ENSMUST00000110491.7 ENSMUST00000110491.8 GPX5_MOUSE NM_010343 P21765 uc007ppz.1 uc007ppz.2 uc007ppz.3 uc007ppz.4 Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; Secreted. Epididymis. Belongs to the glutathione peroxidase family. peroxidase activity glutathione peroxidase activity extracellular region extracellular space response to oxidative stress oxidoreductase activity cellular response to oxidative stress oxidation-reduction process sperm plasma membrane cellular oxidant detoxification uc007ppz.1 uc007ppz.2 uc007ppz.3 uc007ppz.4 
ENSMUST00000110492.2 Prag1 ENSMUST00000110492.2 PEAK1 related kinase activating pseudokinase 1, transcript variant 1 (from RefSeq NM_172911.4) D8Ertd82e E9QLH9 ENSMUST00000110492.1 NM_172911 Nack PRAG1_MOUSE Prag1 Q571I4 Q8CB68 Sgk223 uc009llf.1 uc009llf.2 uc009llf.3 Catalytically inactive protein kinase that acts as a scaffold protein (By similarity). Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (PubMed:25038227). Homodimer (By similarity). Dimerization leads to the catalytic activation of CSK (By similarity). Interacts (via C-terminus) with RND2 (By similarity). Interacts with CSK (via SH2 domain) in a Tyr-391 phosphorylation-dependent manner; this interaction potentiates kinase activity of CSK (By similarity). Interacts with NOTCH1 intracellular domain (N1ICD) (PubMed:25038227). Forms a complex with PRAG1, N1ICD and MAML1, in a MAML1-dependent manner (PubMed:25038227). Cytoplasm Nucleus Cell junction, focal adhesion Note=Colocalized with NOTCH1 in the nucleus (PubMed:25038227). The dimerization region encompasses helices both from the N- and C-terminal of the protein kinase domain. Phosphorylated by CSK on Tyr-238, Tyr-343, and Tyr-391; Tyr-391 is a primary site of phosphorylation. Deficient mice shown complete embryonic lethality (PubMed:25038227). Belongs to the protein kinase superfamily. Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP, suggesting that it has no protein kinase activity. Sequence=AAH89024.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC29528.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD90130.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein kinase activity protein binding nucleus cytoplasm focal adhesion protein phosphorylation regulation of cell shape regulation of Notch signaling pathway negative regulation of neuron projection development cell migration cell junction positive regulation of Rho protein signal transduction identical protein binding regulation of cell motility ATP binding uc009llf.1 uc009llf.2 uc009llf.3 
ENSMUST00000110507.2 8430423G03Rik ENSMUST00000110507.2 RIKEN cDNA 8430423G03 gene (from RefSeq NR_040686.1) ENSMUST00000110507.1 NR_040686 uc029vqt.1 uc029vqt.2 uc029vqt.1 uc029vqt.2 
ENSMUST00000110510.4 Gli3 ENSMUST00000110510.4 GLI-Kruppel family member GLI3 (from RefSeq NM_008130.3) ENSMUST00000110510.1 ENSMUST00000110510.2 ENSMUST00000110510.3 GLI3_MOUSE NM_008130 Q61602 uc007pns.1 uc007pns.2 uc007pns.3 uc007pns.4 Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI- consensus sequence 5'-GGGTGGTC-3'. The phosphorylated form interacts with BTRC (By similarity). The full-length GLI3 form (GLI3FL) interacts with SUFU and this interaction regulates the formation of either repressor or activator forms of GLI3. Its association with SUFU is regulated by Hh signaling and dissociation of the SUFU-GLI3 interaction requires the presence of the ciliary motor KIF3A. Interacts with KIF7. The activator form of GLI3 (GLI3A) but not the repressor form (GLI3R) can interact with TRPS1. Interacts with ZIC1. Interacts with ZIC3 (via C2H2-type domains 3, 4 and 5); the interaction enhances its transcriptional activity (By similarity). Interacts with WRD11; the interaction associates EMX1 with GLI3 (PubMed:29263200). Interacts with DZIP1; retains GLI3 within the cytoplasm (PubMed:23955340). Nucleus Cytoplasm Cell projection, cilium Note=Translocation to the nucleus is promoted by interaction with ZIC1 (By similarity). GLI3FL is localized predominantly in the cytoplasm while GLI3R resides mainly in the nucleus. Ciliary accumulation requires the presence of KIF7 and SMO. Phosphorylated by DYRK2 (in vitro) (By similarity). Phosphorylated on multiple sites by protein kinase A (PKA) and phosphorylation by PKA primes further phosphorylation by CK1 and GSK3. Phosphorylation is essential for its proteolytic processing. Transcriptional repressor GLI3R, a C-terminally truncated form, is generated from the full-length GLI3 protein (GLI3FL/GLI3-190) through proteolytic processing. This process requires PKA-primed phosphorylation of GLI3, ubiquitination of GLI3 and the presence of BTRC. GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. GLI3R formation leads to its dissociation from SUFU, allowing it to translocate into the nucleus, and repress Hh target genes. When Hh signaling is initiated, SUFU dissociates from GLI3FL and this has two consequences. First, GLI3R production is halted. Second, free GLI3FL translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Phosphorylated in vitro by ULK3. Note=Several mutations result in developmental defects of cranofacial and limb structures. In particular the add (anterior digit- pattern deformity) and pdn (polydactyly Nagoya) alleles. Belongs to the GLI C2H2-type zinc-finger protein family. Sequence=CAA64543.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding metanephros development branching involved in ureteric bud morphogenesis in utero embryonic development kidney development positive regulation of neuroblast proliferation nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol cilium axoneme regulation of transcription, DNA-templated smoothened signaling pathway pattern specification process axon guidance central nervous system development brain development hindgut morphogenesis heart development beta-catenin binding negative regulation of cell proliferation anterior/posterior pattern specification dorsal/ventral pattern formation proximal/distal pattern formation regulation of gene expression protein processing nuclear speck transcriptional repressor complex spinal cord dorsal/ventral patterning spinal cord motor neuron differentiation telencephalon development pallium development subpallium development optic nerve morphogenesis hippocampus development smoothened signaling pathway involved in ventral spinal cord interneuron specification smoothened signaling pathway involved in spinal cord motor neuron cell fate specification forebrain dorsal/ventral pattern formation cerebral cortex radial glia guided migration layer formation in cerebral cortex forebrain radial glial cell differentiation neural tube development lateral ganglionic eminence cell proliferation melanocyte differentiation lung development embryonic limb morphogenesis prostate gland development mammary gland development forebrain development positive regulation of chondrocyte differentiation T cell differentiation in thymus histone acetyltransferase binding limb morphogenesis tube development mediator complex binding wound healing regulation of cell proliferation positive regulation of protein import into nucleus odontogenesis of dentin-containing tooth embryonic digit morphogenesis histone deacetylase binding regulation of apoptotic process cell projection camera-type eye development negative regulation of apoptotic process sequence-specific DNA binding tongue development response to estrogen negative thymic T cell selection regulation of cell differentiation negative regulation of cell differentiation negative regulation of neuron differentiation positive regulation of osteoblast differentiation negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of alpha-beta T cell differentiation negative regulation of alpha-beta T cell differentiation metal ion binding embryonic digestive tract morphogenesis embryonic digestive tract development embryonic organ development developmental growth camera-type eye morphogenesis embryonic morphogenesis anatomical structure formation involved in morphogenesis neuron fate commitment embryonic skeletal system morphogenesis oligodendrocyte differentiation branching morphogenesis of an epithelial tube inner ear development anatomical structure development palate development limb development frontal suture morphogenesis lambdoid suture morphogenesis sagittal suture morphogenesis mammary gland specification smoothened signaling pathway involved in dorsal/ventral neural tube patterning artery development anterior semicircular canal development lateral semicircular canal development cell differentiation involved in kidney development thymocyte apoptotic process negative regulation of canonical Wnt signaling pathway liver regeneration regulation of bone development uc007pns.1 uc007pns.2 uc007pns.3 uc007pns.4 
ENSMUST00000110515.9 Mtus2 ENSMUST00000110515.9 microtubule associated tumor suppressor candidate 2, transcript variant 3 (from RefSeq NM_001359505.2) B9EKJ2 Cazip ENSMUST00000110515.1 ENSMUST00000110515.2 ENSMUST00000110515.3 ENSMUST00000110515.4 ENSMUST00000110515.5 ENSMUST00000110515.6 ENSMUST00000110515.7 ENSMUST00000110515.8 Kiaa0774 MTUS2_MOUSE NM_001359505 Q3UHD3 Q7TPP7 Q8CHD2 Q9CY74 Tip150 uc009aop.1 uc009aop.2 uc009aop.3 uc009aop.4 Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip (By similarity). Homodimer. Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules (By similarity). Cytoplasm, cytoskeleton. Note=Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UHD3-1; Sequence=Displayed; Name=3; IsoId=Q3UHD3-3; Sequence=VSP_023545, VSP_023546; Name=4; IsoId=Q3UHD3-4; Sequence=VSP_023544, VSP_023548; Expressed in heart from early embryonic development onwards. Later during embryonic development, expressed in brain and nervous system, in limb buds and in the epithelium lining the bronchia of the lung. Detected in adult brain, heart and eye, but not detected in other adult tissues examined. In the C-terminal section; belongs to the MTUS1 family. Sequence=BAC41447.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; nucleus cytoplasm cytoskeleton microtubule microtubule binding protein homodimerization activity centrosome cytoplasmic microtubule microtubule cytoskeleton uc009aop.1 uc009aop.2 uc009aop.3 uc009aop.4 
ENSMUST00000110516.3 Hecw1 ENSMUST00000110516.3 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (from RefSeq NM_001081348.3) D3YZ67 ENSMUST00000110516.1 ENSMUST00000110516.2 HECW1_MOUSE Kiaa0322 NM_001081348 Nedl1 Q6A086 Q8BIA6 Q8BKC2 Q8BKL3 Q8BKZ8 Q8K4P8 uc007pnd.1 uc007pnd.2 uc007pnd.3 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Protein modification; protein ubiquitination. Interacts with DVL1 and SSR3. Cytoplasm Event=Alternative splicing; Named isoforms=4; Comment=Named isoforms=2.; Name=1; IsoId=Q8K4P8-1; Sequence=Displayed; Name=2; IsoId=Q8K4P8-2; Sequence=VSP_023076; Name=3; IsoId=Q8K4P8-3; Sequence=VSP_023074, VSP_023075; Name=4; IsoId=Q8K4P8-4; Sequence=VSP_023075; Predominantly expressed in neurons of the spinal cord. Sequence=BAC28516.1; Type=Erroneous initiation; Evidence=; protein polyubiquitination ubiquitin-protein transferase activity cytoplasm cytosol ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process regulation of dendrite morphogenesis ubiquitin protein ligase activity negative regulation of sodium ion transmembrane transporter activity uc007pnd.1 uc007pnd.2 uc007pnd.3 
ENSMUST00000110521.3 Slc28a2b ENSMUST00000110521.3 solute carrier family 28 member 2b (from RefSeq NM_001085518.1) A2AWR5 A2AWR5_MOUSE ENSMUST00000110521.1 ENSMUST00000110521.2 Gm14085 NM_001085518 Slc28a2b uc008mav.1 uc008mav.2 Membrane ; Multi- pass membrane protein Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. nucleoside transmembrane transporter activity nucleoside:sodium symporter activity integral component of plasma membrane purine nucleoside transmembrane transporter activity purine nucleoside transmembrane transport membrane integral component of membrane nucleoside transmembrane transport uc008mav.1 uc008mav.2 
ENSMUST00000110525.8 Slc28a2 ENSMUST00000110525.8 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, transcript variant 1 (from RefSeq NM_172980.4) Cnt2 ENSMUST00000110525.1 ENSMUST00000110525.2 ENSMUST00000110525.3 ENSMUST00000110525.4 ENSMUST00000110525.5 ENSMUST00000110525.6 ENSMUST00000110525.7 NM_172980 O88627 Q8BJP1 S28A2_MOUSE uc008mas.1 uc008mas.2 uc008mas.3 Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues. May contribute to regulate the transport of organic compounds in testes across the blood-testis- barrier (By similarity). Reaction=adenosine(out) + Na(+)(out) = adenosine(in) + Na(+)(in); Xref=Rhea:RHEA:69927, ChEBI:CHEBI:16335, ChEBI:CHEBI:29101; Evidence=; Reaction=inosine(out) + Na(+)(out) = inosine(in) + Na(+)(in); Xref=Rhea:RHEA:69931, ChEBI:CHEBI:17596, ChEBI:CHEBI:29101; Evidence=; Reaction=guanosine(out) + Na(+)(out) = guanosine(in) + Na(+)(in); Xref=Rhea:RHEA:69935, ChEBI:CHEBI:16750, ChEBI:CHEBI:29101; Evidence=; Reaction=Na(+)(out) + uridine(out) = Na(+)(in) + uridine(in); Xref=Rhea:RHEA:69887, ChEBI:CHEBI:16704, ChEBI:CHEBI:29101; Evidence=; Membrane ; Multi- pass membrane protein Apicolateral cell membrane ; Multi-pass membrane protein Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. retina homeostasis nucleoside transmembrane transporter activity nucleoside:sodium symporter activity integral component of plasma membrane purine nucleoside transmembrane transporter activity purine nucleoside transmembrane transport membrane integral component of membrane protein localization to cell surface nucleoside transmembrane transport uc008mas.1 uc008mas.2 uc008mas.3 
ENSMUST00000110531.9 Shf ENSMUST00000110531.9 Src homology 2 domain containing F, transcript variant 2 (from RefSeq NM_001013829.2) A2AQ90 A2AQ91 ENSMUST00000110531.1 ENSMUST00000110531.2 ENSMUST00000110531.3 ENSMUST00000110531.4 ENSMUST00000110531.5 ENSMUST00000110531.6 ENSMUST00000110531.7 ENSMUST00000110531.8 NM_001013829 Q8CG80 SHF_MOUSE Shf uc008mar.1 uc008mar.2 uc008mar.3 Adapter protein which may play a role in the regulation of apoptosis in response to PDGF. Interacts with phosphorylated 'Tyr-720' of PDGFRA via its SH2 domain. Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist. ; Name=1 ; IsoId=Q8CG80-1; Sequence=Displayed; Name=2; IsoId=Q8CG80-2; Sequence=VSP_052700; May become phosphorylated upon binding to PDGFRA. phosphotyrosine binding cellular_component apoptotic process uc008mar.1 uc008mar.2 uc008mar.3 
ENSMUST00000110534.8 Arid4b ENSMUST00000110534.8 AT-rich interaction domain 4B, transcript variant 1 (from RefSeq NM_194262.2) A2CG61 A2CG62 A2CG63 A2CG64 ARI4B_MOUSE B2RQ67 ENSMUST00000110534.1 ENSMUST00000110534.2 ENSMUST00000110534.3 ENSMUST00000110534.4 ENSMUST00000110534.5 ENSMUST00000110534.6 ENSMUST00000110534.7 NM_194262 Q8BMI8 Q8BYA5 Sap180 uc007pmz.1 uc007pmz.2 uc007pmz.3 uc007pmz.4 Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A (PubMed:17043311). Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (PubMed:23487765). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (PubMed:18728284). Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2 (By similarity). Interacts with ARID4A (PubMed:17043311). Interacts with AR (PubMed:23487765). A2CG63; P70278: Stra8; NbExp=4; IntAct=EBI-6394082, EBI-6394115; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2CG63-1; Sequence=Displayed; Name=2; IsoId=A2CG63-2; Sequence=VSP_024236; Expressed in Sertoli cells of the testis. The C-terminus mediates interaction with mSin3A corepressor complex. The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms. The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA. Embryonic lethal. Lethality occurs between embryonic day E3.5 and E7.5 (PubMed:17043311). Heterozygous males are fully fertile (PubMed:23487765). Double knockouts of ARID4B heterozygotes with ARID4A homozygotes show various hematological abnormalities, which are more severe than the ARID4A phenotype alone. Hematopoietic stem cell (HSC) and common myeloid progenitor (CMP) counts in bone marrow and spleen are increased. Lymphocyte numbers in spleen are significantly reduced. In peripheral blood, red blood cell counts and lymphocyte counts are reduced. Approximately 83% of animals develop acute myeloid leukemia (AML) and/or myeloid sarcoma. In bone marrow cells, expression of FOXP3 is significantly reduced (PubMed:18728284). Expression of HOXB3, HOXB5, HOXB6, HOXB8 and PITX2 in bone marrow cells is reduced (PubMed:17043311). Males show progressive reduction in fertility from 2 months of age onwards, with reduced testis size and variable defects in seminal vesicle formation. Spermatogenesis is partially blocked from the meiosis II stage onwards leading to reduced numbers of mature spermatozoa. Expression in testis of CLDN3, an androgen receptor-regulated gene, is significantly reduced. Expression of PTGDS is also reduced, whereas expression of INHA and EMB is moderately increased (PubMed:23487765). Sequence=CAM21242.1; Type=Erroneous gene model prediction; Evidence=; DNA binding protein binding nucleus chromatin organization regulation of gene expression by genetic imprinting regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter spermatogenesis histone H4-K20 trimethylation histone H3-K9 trimethylation transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter establishment of Sertoli cell barrier uc007pmz.1 uc007pmz.2 uc007pmz.3 uc007pmz.4 
ENSMUST00000110537.8 Duoxa1 ENSMUST00000110537.8 dual oxidase maturation factor 1 (from RefSeq NM_001305262.1) A2AQ97 DOXA1_MOUSE ENSMUST00000110537.1 ENSMUST00000110537.2 ENSMUST00000110537.3 ENSMUST00000110537.4 ENSMUST00000110537.5 ENSMUST00000110537.6 ENSMUST00000110537.7 NM_001305262 Q8VE49 uc008mao.1 uc008mao.2 uc008mao.3 May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1. May interact with NUMB. Membrane ; Multi-pass membrane protein Belongs to the DUOXA family. protein binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane protein localization positive regulation of hydrogen peroxide biosynthetic process protein transport membrane integral component of membrane enzyme binding cell leading edge cellular protein localization hydrogen peroxide metabolic process positive regulation of neuron differentiation regulation of inflammatory response positive regulation of reactive oxygen species metabolic process regulation of thyroid hormone generation uc008mao.1 uc008mao.2 uc008mao.3 
ENSMUST00000110542.8 Agxt2 ENSMUST00000110542.8 alanine-glyoxylate aminotransferase 2, transcript variant 2 (from RefSeq NM_001310736.1) AGT2_MOUSE B9EIZ8 ENSMUST00000110542.1 ENSMUST00000110542.2 ENSMUST00000110542.3 ENSMUST00000110542.4 ENSMUST00000110542.5 ENSMUST00000110542.6 ENSMUST00000110542.7 NM_001310736 Q3UEG6 uc007vga.1 uc007vga.2 uc007vga.3 uc007vga.4 Multifunctional aminotransferase with a broad substrate specifcity (PubMed:23023372, PubMed:23280748, PubMed:23154179, PubMed:27062388). Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor (By similarity). Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine (PubMed:27062388). Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L- alanine and 3-oxopropanoate (PubMed:27062388). Can metabolize NG- monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA) (PubMed:23023372, PubMed:23280748, PubMed:23154179). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (PubMed:23023372). Reaction=glyoxylate + L-alanine = glycine + pyruvate; Xref=Rhea:RHEA:24248, ChEBI:CHEBI:15361, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:57972; EC=2.6.1.44; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24249; Evidence=; Reaction=(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3- oxopropanoate + L-alanine; Xref=Rhea:RHEA:18393, ChEBI:CHEBI:15361, ChEBI:CHEBI:57700, ChEBI:CHEBI:57731, ChEBI:CHEBI:57972; EC=2.6.1.40; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18394; Evidence=; Reaction=3-oxopropanoate + L-alanine = beta-alanine + pyruvate; Xref=Rhea:RHEA:14077, ChEBI:CHEBI:15361, ChEBI:CHEBI:33190, ChEBI:CHEBI:57966, ChEBI:CHEBI:57972; EC=2.6.1.18; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:14079; Evidence=; Reaction=2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate; Xref=Rhea:RHEA:77355, ChEBI:CHEBI:15361, ChEBI:CHEBI:16763, ChEBI:CHEBI:57972, ChEBI:CHEBI:74359; EC=2.6.1.44; Evidence=; Reaction=N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3- dimethylguanidino)-2-oxopentanoate + L-alanine; Xref=Rhea:RHEA:77303, ChEBI:CHEBI:15361, ChEBI:CHEBI:57972, ChEBI:CHEBI:58326, ChEBI:CHEBI:197301; Evidence= Reaction=N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'- dimethylguanidino)-2-oxopentanoate + L-alanine; Xref=Rhea:RHEA:77307, ChEBI:CHEBI:15361, ChEBI:CHEBI:57972, ChEBI:CHEBI:197308, ChEBI:CHEBI:197310; Evidence=; Reaction=glyoxylate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3- dimethylguanidino)-2-oxopentanoate + glycine; Xref=Rhea:RHEA:77311, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:58326, ChEBI:CHEBI:197301; Evidence=; Reaction=glyoxylate + N(omega),N('omega)-dimethyl-L-arginine = 5-(3,3'- dimethylguanidino)-2-oxopentanoate + glycine; Xref=Rhea:RHEA:77315, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:197308, ChEBI:CHEBI:197310; Evidence=; Reaction=N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)- 2-oxopentanoate + L-alanine; Xref=Rhea:RHEA:77319, ChEBI:CHEBI:15361, ChEBI:CHEBI:57972, ChEBI:CHEBI:114953, ChEBI:CHEBI:197314; Evidence=; Reaction=glyoxylate + N(omega)-methyl-L-arginine = 5-(3- methylguanidino)-2-oxopentanoate + glycine; Xref=Rhea:RHEA:77323, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:114953, ChEBI:CHEBI:197314; Evidence=; Reaction=L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine; Xref=Rhea:RHEA:77327, ChEBI:CHEBI:15361, ChEBI:CHEBI:46911, ChEBI:CHEBI:57972, ChEBI:CHEBI:58802; Evidence=; Reaction=glyoxylate + L-ornithine = 5-amino-2-oxopentanoate + glycine; Xref=Rhea:RHEA:77331, ChEBI:CHEBI:36655, ChEBI:CHEBI:46911, ChEBI:CHEBI:57305, ChEBI:CHEBI:58802; Evidence=; Reaction=(2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine; Xref=Rhea:RHEA:77339, ChEBI:CHEBI:16763, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:74359; Evidence=; Reaction=N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3- dimethylguanidino)-2-oxopentanoate + L-aspartate; Xref=Rhea:RHEA:77343, ChEBI:CHEBI:16452, ChEBI:CHEBI:29991, ChEBI:CHEBI:58326, ChEBI:CHEBI:197301; Evidence=; Reaction=L-alanine + oxaloacetate = L-aspartate + pyruvate; Xref=Rhea:RHEA:77347, ChEBI:CHEBI:15361, ChEBI:CHEBI:16452, ChEBI:CHEBI:29991, ChEBI:CHEBI:57972; Evidence=; Reaction=2-oxobutanoate + N(omega),N(omega)-dimethyl-L-arginine = (2S)- 2-aminobutanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate; Xref=Rhea:RHEA:77351, ChEBI:CHEBI:16763, ChEBI:CHEBI:58326, ChEBI:CHEBI:74359, ChEBI:CHEBI:197301; Evidence=; Reaction=2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5- (3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate; Xref=Rhea:RHEA:77359, ChEBI:CHEBI:28644, ChEBI:CHEBI:58326, ChEBI:CHEBI:58441, ChEBI:CHEBI:197301; Evidence=; Reaction=2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = 5- (3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminohexanoate; Xref=Rhea:RHEA:77363, ChEBI:CHEBI:35177, ChEBI:CHEBI:58326, ChEBI:CHEBI:58455, ChEBI:CHEBI:197301; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; (R)-3-amino-2-methylpropionate--pyruvate transaminase and beta-alanine-pyruvate aminotransferase are inhibited by aminooxyacetic acid. Homotetramer. Mitochondrion Expressed in the liver and kidney. Knockout mice are hypertensive. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. catalytic activity mitochondrion alanine-glyoxylate transaminase activity transaminase activity glyoxylate catabolic process transferase activity glycine biosynthetic process, by transamination of glyoxylate L-alanine catabolic process, by transamination pyridoxal phosphate binding positive regulation of nitric oxide biosynthetic process (R)-3-amino-2-methylpropionate-pyruvate transaminase activity uc007vga.1 uc007vga.2 uc007vga.3 uc007vga.4 
ENSMUST00000110551.4 Sord ENSMUST00000110551.4 sorbitol dehydrogenase (from RefSeq NM_146126.4) DHSO_MOUSE ENSMUST00000110551.1 ENSMUST00000110551.2 ENSMUST00000110551.3 NM_146126 Q569V5 Q64442 Q9CPS0 Sdh1 uc008maj.1 uc008maj.2 uc008maj.3 Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols (By similarity). Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose (PubMed:6852349). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility and protein tyrosine phosphorylation (PubMed:18799757). Has no activity on ethanol. Cannot use NADP(+) as the electron acceptor (PubMed:6852349). Reaction=H(+) + keto-D-fructose + NADH = D-sorbitol + NAD(+); Xref=Rhea:RHEA:33031, ChEBI:CHEBI:15378, ChEBI:CHEBI:17924, ChEBI:CHEBI:48095, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=NAD(+) + xylitol = D-xylulose + H(+) + NADH; Xref=Rhea:RHEA:20433, ChEBI:CHEBI:15378, ChEBI:CHEBI:17140, ChEBI:CHEBI:17151, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.9; Evidence=; Reaction=L-iditol + NAD(+) = H(+) + keto-L-sorbose + NADH; Xref=Rhea:RHEA:10160, ChEBI:CHEBI:13172, ChEBI:CHEBI:15378, ChEBI:CHEBI:18202, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.14; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Inhibited in vitro by p-hydroxymercuribenzoate, EDTA, l,l0-phenanthroline and N-ethylmaleimide. Kinetic parameters: KM=1.54 mM for sorbitol ; KM=58.8 uM for NAD(+) ; KM=154 mM for fructose ; KM=15 uM for NADH ; pH dependence: Optimum pH is 9.0 for sorbitol oxidation and 7.5 for D-fructose reduction. ; Homotetramer. Mitochondrion membrane ; Peripheral membrane protein Cell projection, cilium, flagellum Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. Testis has the highest level of expression, followed by kidney, liver, and lung. Low levels of expression are also observed in lens, brain, and skeletal muscle. Expressed in sperm flagellum and very low expression in the sperm head. Detected early in spermatogenesis. Detected in condensing spermatids (at protein level) and is up-regulated during late spermatogenesis. Belongs to the zinc-containing alcohol dehydrogenase family. Sequence=AAA79043.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; L-iditol 2-dehydrogenase activity mitochondrion cilium sorbitol metabolic process sorbitol catabolic process response to osmotic stress zinc ion binding response to hormone membrane oxidoreductase activity flagellated sperm motility motile cilium response to nutrient levels mitochondrial membrane response to drug identical protein binding cell projection fructose biosynthetic process D-xylulose reductase activity response to cadmium ion response to copper ion metal ion binding L-xylitol catabolic process L-xylitol metabolic process NAD binding oxidation-reduction process extracellular exosome uc008maj.1 uc008maj.2 uc008maj.3 
ENSMUST00000110559.3 Lyst ENSMUST00000110559.3 lysosomal trafficking regulator (from RefSeq NM_010748.2) ENSMUST00000110559.1 ENSMUST00000110559.2 G5E8Q0 G5E8Q0_MOUSE Lyst NM_010748 uc007pmj.1 uc007pmj.2 uc007pmj.3 lysosome organization microtubule cytoskeleton endosome to lysosome transport via multivesicular body sorting pathway natural killer cell mediated cytotoxicity pigmentation uc007pmj.1 uc007pmj.2 uc007pmj.3 
ENSMUST00000110560.3 Gm3086 ENSMUST00000110560.3 predicted gene 3086 (from RefSeq NR_036607.1) ENSMUST00000110560.1 ENSMUST00000110560.2 NR_036607 uc007ntd.1 uc007ntd.2 uc007ntd.3 uc007ntd.4 uc007ntd.1 uc007ntd.2 uc007ntd.3 uc007ntd.4 
ENSMUST00000110570.8 Map4k5 ENSMUST00000110570.8 mitogen-activated protein kinase kinase kinase kinase 5 (from RefSeq NM_201519.2) ENSMUST00000110570.1 ENSMUST00000110570.2 ENSMUST00000110570.3 ENSMUST00000110570.4 ENSMUST00000110570.5 ENSMUST00000110570.6 ENSMUST00000110570.7 M4K5_MOUSE Map4k5 NM_201519 Q6PEQ2 Q8BPM2 Q8C3U5 Q8CGF3 Q99LM7 Q9CX73 uc288gxw.1 uc288gxw.2 May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with both SH3 domains of the adapter proteins CRK and CRKL. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8BPM2-1; Sequence=Displayed; Name=2 ; IsoId=Q8BPM2-2; Sequence=VSP_050478; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. MAPK cascade nucleotide binding activation of MAPKKK activity protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm protein phosphorylation MAP kinase kinase kinase kinase activity kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation activation of protein kinase activity intracellular signal transduction uc288gxw.1 uc288gxw.2 
ENSMUST00000110576.4 ENSMUSG00000094303 ENSMUST00000110576.4 ENSMUSG00000094303 (from geneSymbol) ENSMUST00000110576.1 ENSMUST00000110576.2 ENSMUST00000110576.3 uc291cfe.1 uc291cfe.2 uc291cfe.1 uc291cfe.2 
ENSMUST00000110582.4 Jrkl ENSMUST00000110582.4 Jrk-like (from RefSeq NM_001033181.1) B2RRL2 ENSMUST00000110582.1 ENSMUST00000110582.2 ENSMUST00000110582.3 JERKL_MOUSE NM_001033181 Q3V2Y6 uc012hdj.1 uc012hdj.2 uc012hdj.3 Nucleus Belongs to the tigger transposable element derived protein family. Sequence=BAE43369.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE43369.1; Type=Frameshift; Evidence=; molecular_function nucleic acid binding DNA binding cellular_component nucleus biological_process uc012hdj.1 uc012hdj.2 uc012hdj.3 
ENSMUST00000110592.2 Frmd5 ENSMUST00000110592.2 FERM domain containing 5, transcript variant 1 (from RefSeq NM_001360084.1) A2AR56 A2AR56_MOUSE ENSMUST00000110592.1 Frmd5 NM_001360084 uc289zzb.1 uc289zzb.2 cytoskeleton cytoskeletal protein binding membrane integral component of membrane uc289zzb.1 uc289zzb.2 
ENSMUST00000110594.4 Prl2c2 ENSMUST00000110594.4 prolactin family 2, subfamily c, member 2 (from RefSeq NM_031191.2) B7ZNU8 ENSMUST00000110594.1 ENSMUST00000110594.2 ENSMUST00000110594.3 Mrp1 NM_031191 P04095 PR2C2_MOUSE Plf Plf1 Q498A4 Q61899 uc007plx.1 uc007plx.2 uc007plx.3 May have a role in embryonic development. It is likely to provide a growth stimulus to target cells in maternal and fetal tissues during the development of the embryo at mid-gestation. May play a role during wound healing and in the hair follicle cycle as a growth factor and/or an angiogenesis factor. May play a role in microvilli formation and cell proliferation of neuroblastoma cells. Secreted doplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P04095-1; Sequence=Displayed; Name=2; IsoId=P04095-2; Sequence=VSP_043544; Expressed in brain and cerebellum (PubMed:16876275). Expressed in placenta and hair follicles, with highest expression levels detected in the outer root sheath and no expression detected in bulb (PubMed:11316781, PubMed:10537154). Also expressed in body fluids such as plasma and amniotic fluid (PubMed:10537154). Expressed in embryonic fibroblasts and at low levels in keratinocytes (PubMed:11316781). Isoform 1: Expressed in brain and Neuro-2a cells (PubMed:16876275). Isoform 2: Expressed in brain (PubMed:16876275). Expressed at low levels during hair follicle morphogenesis, with highest expression levels detected at late anagen stage of the hair follicle cycle (PubMed:11316781). Expressed in developing brain from embryo to adult (PubMed:16876275). In placenta, detected at 8 dpc, peaks at 10 dpc and declines thereafter (PubMed:10537154). N-glycosylated and sialylated. Belongs to the somatotropin/prolactin family. sprouting angiogenesis positive regulation of neuroblast proliferation prolactin receptor binding hormone activity protein binding extracellular region extracellular space endoplasmic reticulum signal transduction female pregnancy growth factor activity positive regulation of cell proliferation mammary gland development positive regulation of cell projection organization response to nutrient levels regulation of microvillus assembly positive regulation of blood vessel endothelial cell migration negative regulation of myoblast differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade positive regulation of lactation uc007plx.1 uc007plx.2 uc007plx.3 
ENSMUST00000110595.3 Gm3415 ENSMUST00000110595.3 Gm3415 (from geneSymbol) ENSMUST00000110595.1 ENSMUST00000110595.2 Gm3415 L7N249 L7N249_MOUSE uc291buc.1 uc291buc.2 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc291buc.1 uc291buc.2 
ENSMUST00000110596.2 Gm3404 ENSMUST00000110596.2 predicted gene 3404 (from RefSeq NM_001243109.1) ENSMUST00000110596.1 Gm3404 NM_001243109 Q9D506 Q9D506_MOUSE uc009anh.1 uc009anh.2 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc009anh.1 uc009anh.2 
ENSMUST00000110598.3 4930449I24Rik ENSMUST00000110598.3 RIKEN cDNA 4930449I24 gene (from RefSeq NM_026136.2) 4930449I24Rik ENSMUST00000110598.1 ENSMUST00000110598.2 NM_026136 Q9D5E3 Q9D5E3_MOUSE uc009ang.1 uc009ang.2 uc009ang.3 uc009ang.4 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc009ang.1 uc009ang.2 uc009ang.3 uc009ang.4 
ENSMUST00000110602.9 Wdr76 ENSMUST00000110602.9 WD repeat domain 76, transcript variant 1 (from RefSeq NM_030234.2) A2ASQ8 A4FUV0 A6PWY4 ENSMUST00000110602.1 ENSMUST00000110602.2 ENSMUST00000110602.3 ENSMUST00000110602.4 ENSMUST00000110602.5 ENSMUST00000110602.6 ENSMUST00000110602.7 ENSMUST00000110602.8 NM_030234 Q504Z3 Q9CTV4 WDR76_MOUSE uc056zov.1 uc056zov.2 uc056zov.3 uc056zov.4 Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Interacts with CUL4A and/or CUL4B. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A6PWY4-1; Sequence=Displayed; Name=2; IsoId=A6PWY4-2; Sequence=VSP_035463; Name=3; IsoId=A6PWY4-3; Sequence=VSP_035464, VSP_035465, VSP_035466; Belongs to the WD repeat DDB2/WDR76 family. heterochromatin DNA binding nucleus cellular response to DNA damage stimulus enzyme binding regulation of DNA damage checkpoint uc056zov.1 uc056zov.2 uc056zov.3 uc056zov.4 
ENSMUST00000110610.8 Ash2l ENSMUST00000110610.8 ASH2 like histone lysine methyltransferase complex subunit, transcript variant 2 (from RefSeq NM_001080793.2) Ash2l E9PU93 E9PU93_MOUSE ENSMUST00000110610.1 ENSMUST00000110610.2 ENSMUST00000110610.3 ENSMUST00000110610.4 ENSMUST00000110610.5 ENSMUST00000110610.6 ENSMUST00000110610.7 NM_001080793 uc009lhd.1 uc009lhd.2 uc009lhd.3 uc009lhd.4 uc009lhd.5 Nucleus Set1C/COMPASS complex histone H3-K4 methylation uc009lhd.1 uc009lhd.2 uc009lhd.3 uc009lhd.4 uc009lhd.5 
ENSMUST00000110612.8 Hypk ENSMUST00000110612.8 Hypk (from geneSymbol) A0A8Q0PQH5 A0A8Q0PQH5_MOUSE BC060244 ENSMUST00000110612.1 ENSMUST00000110612.2 ENSMUST00000110612.3 ENSMUST00000110612.4 ENSMUST00000110612.5 ENSMUST00000110612.6 ENSMUST00000110612.7 Hypk uc008lzf.1 uc008lzf.2 uc008lzf.3 uc008lzf.4 uc008lzf.1 uc008lzf.2 uc008lzf.3 uc008lzf.4 
ENSMUST00000110617.2 Cplane1 ENSMUST00000110617.2 ciliogenesis and planar polarity effector 1 (from RefSeq NM_001162906.2) CPLN1_MOUSE Cplane1 E9QL36 ENSMUST00000110617.1 Jbts17 NM_001162906 Q3UXY6 Q6PEE0 Q8CE72 uc007ven.1 uc007ven.2 uc007ven.3 Involved in ciliogenesis. Involved in the establishment of cell polarity required for directional cell migration (PubMed:25877302). Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). Interacts with FUZ; INTU and WDPCP; the interactors are proposed to form the core CPLANE (ciliogenesis and planar polarity effectors) complex (PubMed:27158779). Membrane ; Multi-pass membrane protein Cell projection, cilium Note=Localizes to the ciliary transition zone. Note=Defects in Jbts17 are the cause of the Hug (Heart under glass) phenotype which is a model of Joubert syndrome. Hug mice die prenatally and show skelatal dysplasia, craniofacial defects, polydactyly, cystic kidney, cerebellar hypoplasia and congenital heart defects of varying degrees. Most severely affected mutants die at mid- gestation with a transparent chest wall due to complete failure to form the rib cage. The phenotype is consistent with the spectrum of MKS-BBS- Joubert syndrome phenotypes. Sequence=AAH58107.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE22427.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Intron sequences at both 5' and 3' ends.; Evidence=; establishment of planar polarity kidney development cardiac septum development ventricular septum development molecular_function cilium heart development membrane integral component of membrane cerebellum development cell projection organization ciliary transition zone embryonic digit morphogenesis cell projection palate development cilium assembly coronary vasculature development protein localization to ciliary transition zone uc007ven.1 uc007ven.2 uc007ven.3 
ENSMUST00000110621.3 Lrr1 ENSMUST00000110621.3 leucine rich repeat protein 1, transcript variant 1 (from RefSeq NM_001081406.2) D3YY91 ENSMUST00000110621.1 ENSMUST00000110621.2 LLR1_MOUSE Lrr1 NM_001081406 uc007nrq.1 uc007nrq.2 uc007nrq.3 Substrate recognition subunit of an ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:33590678). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S- phase (PubMed:33590678). May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1 (By similarity). Protein modification; protein ubiquitination. Component of the probable ECS(LRR1) E3 ubiquitin-protein ligase complex which contains CUL2, RBX1, Elongin BC complex and LRR1. Interacts with CUL2, RBX1, ELOB and ELOC. Nucleus molecular_function uc007nrq.1 uc007nrq.2 uc007nrq.3 
ENSMUST00000110636.9 Zmynd11 ENSMUST00000110636.9 zinc finger, MYND domain containing 11, transcript variant 5 (from RefSeq NM_001347476.1) ENSMUST00000110636.1 ENSMUST00000110636.2 ENSMUST00000110636.3 ENSMUST00000110636.4 ENSMUST00000110636.5 ENSMUST00000110636.6 ENSMUST00000110636.7 ENSMUST00000110636.8 G5E8Q2 NM_001347476 Q8C155 Q8R5C8 ZMY11_MOUSE uc007pkz.1 uc007pkz.2 uc007pkz.3 uc007pkz.4 Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage (PubMed:24590075). Binds non-specifically to dsDNA (By similarity). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth (PubMed:24590075). Homooligomer; forms homooligomers via its C-terminus. Interacts with histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3). Interacts (via MYND-type zinc finger) with NCOR1. Interacts (via MYND- type zinc finger) with MGA protein (via PXLXP motif). Interacts (via MYND-type zinc finger) with EZH2. Interacts with EMSY and E2F6. Interacts with PIAS1 and UBE2I (By similarity). Q8R5C8; P84243: H3-3B; Xeno; NbExp=6; IntAct=EBI-647813, EBI-120658; Q8R5C8; P68431: H3C12; Xeno; NbExp=4; IntAct=EBI-647813, EBI-79722; Nucleus Chromosome Note=Associates with chromatin and mitotic chromosomes. The PWWP domain specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and adopts a five-bladed beta- barrel fold with an extended C-terminal alpha-helix, with a conserved H3.3K36me3-binding aromatic cage formed by Phe-291 and Trp-294 of the beta1-beta2 loop and Phe-310 of the beta3-beta4 loop. Specific recognition of H3.3 histone is mediated by the encapsulation of the H3.3-specific 'Ser 31' residue in a composite pocket formed by the tandem bromo-PWWP domains (PubMed:24590075). Ubiquitinated, leading to proteasomal degradation. Sumoylated following its interaction with PIAS1 and UBE2I. Sequence=AAH22945.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; DNA binding double-stranded DNA binding transcription corepressor activity protein binding nucleus nucleoplasm chromosome chromatin organization zinc ion binding regulation of transcription elongation from RNA polymerase II promoter methylated histone binding histone binding negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of JNK cascade metal ion binding defense response to virus negative regulation of nucleic acid-templated transcription negative regulation of extrinsic apoptotic signaling pathway uc007pkz.1 uc007pkz.2 uc007pkz.3 uc007pkz.4 
ENSMUST00000110647.8 Trp53bp1 ENSMUST00000110647.8 transformation related protein 53 binding protein 1, transcript variant 2 (from RefSeq NM_001290830.2) A0A5H1ZRL7 A0A5H1ZRL7_MOUSE ENSMUST00000110647.1 ENSMUST00000110647.2 ENSMUST00000110647.3 ENSMUST00000110647.4 ENSMUST00000110647.5 ENSMUST00000110647.6 ENSMUST00000110647.7 NM_001290830 Trp53bp1 uc008lye.1 uc008lye.2 uc008lye.3 uc008lye.4 uc008lye.5 uc008lye.6 Nucleus uc008lye.1 uc008lye.2 uc008lye.3 uc008lye.4 uc008lye.5 uc008lye.6 
ENSMUST00000110658.8 Tubgcp4 ENSMUST00000110658.8 tubulin, gamma complex component 4, transcript variant 3 (from RefSeq NM_001290824.2) D2Ertd435e ENSMUST00000110658.1 ENSMUST00000110658.2 ENSMUST00000110658.3 ENSMUST00000110658.4 ENSMUST00000110658.5 ENSMUST00000110658.6 ENSMUST00000110658.7 NM_001290824 Q8BYN2 Q8BYN2_MOUSE Tubgcp4 uc008lxw.1 uc008lxw.2 uc008lxw.3 Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Belongs to the TUBGCP family. microtubule cytoskeleton organization spindle pole cytoplasm microtubule organizing center cytoskeleton microtubule microtubule nucleation gamma-tubulin binding uc008lxw.1 uc008lxw.2 uc008lxw.3 
ENSMUST00000110671.3 Sstr1 ENSMUST00000110671.3 somatostatin receptor 1, transcript variant 1 (from RefSeq NM_009216.3) ENSMUST00000110671.1 ENSMUST00000110671.2 NM_009216 Q543T0 Q543T0_MOUSE Sstr1 uc033gdq.1 uc033gdq.2 uc033gdq.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity somatostatin receptor activity cytoplasm plasma membrane signal transduction G-protein coupled receptor signaling pathway spermatogenesis membrane integral component of membrane cerebellum development forebrain development somatostatin signaling pathway response to starvation cellular response to estradiol stimulus uc033gdq.1 uc033gdq.2 uc033gdq.3 
ENSMUST00000110672.8 Kpna7 ENSMUST00000110672.8 karyopherin subunit alpha 7, transcript variant 2 (from RefSeq NM_001013774.2) C0LLJ0 C0LLJ1 ENSMUST00000110672.1 ENSMUST00000110672.2 ENSMUST00000110672.3 ENSMUST00000110672.4 ENSMUST00000110672.5 ENSMUST00000110672.6 ENSMUST00000110672.7 IMA8_MOUSE NM_001013774 Q3UWY3 Q58HC5 uc009aly.1 uc009aly.2 uc009aly.3 Functions in nuclear protein import. Binds to importin subunit beta-1/KPNB1 via the IBB domain; this complex dissociates in the presence of RAN-GTP. Shows a limited binding to the RB1 nuclear localization signal (NLS), but not to the SV40, nor NPM1 NLSs. Interacts with RSL1D1. Nucleus Note=In MII-stage oocytes, localizes to the spindle. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=C0LLJ0-1; Sequence=Displayed; Name=2; IsoId=C0LLJ0-2; Sequence=VSP_041924; Expressed predominantly in ovary. Isoform 1 is the predominant form. Expressed at high levels in germinal vesicle-stage oocytes, as well as in zygotes and 2-cell embryos (at protein level). Drastically down-regulated after the 2-cell stage. Mutant mice exhibit abnormal preimplantation development. About half of the mutant embryos fail to develop into the blastocyst stage, or are delayed. Lethality is greater among female than among male embryos. Belongs to the importin alpha family. blastocyst development protein binding nucleus nuclear pore nucleoplasm cytoplasm spindle cytosol protein import into nucleus NLS-bearing protein import into nucleus nuclear localization sequence binding positive regulation of gene expression negative regulation of gene expression protein transport nuclear import signal receptor activity positive regulation of histone H3-K27 trimethylation uc009aly.1 uc009aly.2 uc009aly.3 
ENSMUST00000110674.4 Lcmt2 ENSMUST00000110674.4 leucine carboxyl methyltransferase 2 (from RefSeq NM_177846.3) A2ART9 ENSMUST00000110674.1 ENSMUST00000110674.2 ENSMUST00000110674.3 Kiaa0547 NM_177846 Q3T9F7 Q6A048 Q8BIG6 Q8BYR1 TYW4_MOUSE Tyw4 uc008lxn.1 uc008lxn.2 uc008lxn.3 uc008lxn.4 Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues. Reaction=7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S- adenosyl-L-methionine = 7-[(3S)-(3-amino-3- methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:36903, Rhea:RHEA-COMP:10379, Rhea:RHEA- COMP:11844, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73543, ChEBI:CHEBI:74275; EC=2.1.1.290; Reaction=7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L- homocysteine + wybutosine(37) in tRNA(Phe); Xref=Rhea:RHEA:37119, Rhea:RHEA-COMP:11844, Rhea:RHEA-COMP:11847, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73544, ChEBI:CHEBI:74275; EC=2.3.1.231; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. Interacts with RNF144B/IBRDC2. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BYR1-1; Sequence=Displayed; Name=2; IsoId=Q8BYR1-2; Sequence=VSP_010357, VSP_010358; Belongs to the methyltransferase superfamily. LCMT family. Sequence=BAC35760.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32248.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein C-terminal carboxyl O-methyltransferase activity C-terminal protein methylation tRNA processing methyltransferase activity tRNA methyltransferase activity transferase activity tRNA methylation wybutosine biosynthetic process methylation uc008lxn.1 uc008lxn.2 uc008lxn.3 uc008lxn.4 
ENSMUST00000110675.3 Tgm7 ENSMUST00000110675.3 transglutaminase 7 (from RefSeq NM_001160424.1) A2ART8 A2ART8_MOUSE ENSMUST00000110675.1 ENSMUST00000110675.2 NM_001160424 Tgm7 uc289zvn.1 uc289zvn.2 uc289zvn.3 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Belongs to the transglutaminase superfamily. Transglutaminase family. protein-glutamine gamma-glutamyltransferase activity cellular_component peptide cross-linking metal ion binding uc289zvn.1 uc289zvn.2 uc289zvn.3 
ENSMUST00000110689.5 C7 ENSMUST00000110689.5 complement component 7 (from RefSeq NM_001243837.2) C7 D3YXF5 D3YXF5_MOUSE ENSMUST00000110689.1 ENSMUST00000110689.2 ENSMUST00000110689.3 ENSMUST00000110689.4 NM_001243837 uc011zqy.1 uc011zqy.2 uc011zqy.3 uc011zqy.4 Secreted Belongs to the complement C6/C7/C8/C9 family. Lacks conserved residue(s) required for the propagation of feature annotation. membrane attack complex cellular sodium ion homeostasis immune response complement activation uc011zqy.1 uc011zqy.2 uc011zqy.3 uc011zqy.4 
ENSMUST00000110690.9 Oxct1 ENSMUST00000110690.9 3-oxoacid CoA transferase 1 (from RefSeq NM_024188.6) ENSMUST00000110690.1 ENSMUST00000110690.2 ENSMUST00000110690.3 ENSMUST00000110690.4 ENSMUST00000110690.5 ENSMUST00000110690.6 ENSMUST00000110690.7 ENSMUST00000110690.8 NM_024188 Oxct Q3TIW6 Q9CV92 Q9D0K2 SCOT1_MOUSE Scot uc007vck.1 uc007vck.2 uc007vck.3 uc007vck.4 Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl- CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (By similarity). Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor (3-oxo acid) carboxylate and produce a new acyl- CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate; Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973, ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24565; Evidence=; Reaction=acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate; Xref=Rhea:RHEA:25480, ChEBI:CHEBI:13705, ChEBI:CHEBI:30031, ChEBI:CHEBI:57286, ChEBI:CHEBI:57292; EC=2.8.3.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25481; Evidence=; Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. Homodimer. Only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid). Mitochondrion Belongs to the 3-oxoacid CoA-transferase family. nucleoplasm mitochondrion mitochondrial matrix brain development heart development response to nutrient 3-oxoacid CoA-transferase activity CoA-transferase activity response to hormone response to activity transferase activity positive regulation of insulin secretion involved in cellular response to glucose stimulus ketone catabolic process response to drug response to starvation protein homodimerization activity response to ethanol cellular ketone body metabolic process ketone body catabolic process adipose tissue development uc007vck.1 uc007vck.2 uc007vck.3 uc007vck.4 
ENSMUST00000110696.8 Kat6a ENSMUST00000110696.8 K(lysine) acetyltransferase 6A, transcript variant 2 (from RefSeq NM_001364449.1) ENSMUST00000110696.1 ENSMUST00000110696.2 ENSMUST00000110696.3 ENSMUST00000110696.4 ENSMUST00000110696.5 ENSMUST00000110696.6 ENSMUST00000110696.7 G3X940 G3X940_MOUSE Kat6a Myst3 NM_001364449 uc009led.1 uc009led.2 uc009led.3 Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence= Nucleus Belongs to the MYST (SAS/MOZ) family. nucleosome DNA binding transcription coactivator activity histone acetyltransferase activity nucleus nucleolus cytosol nucleosome assembly regulation of transcription, DNA-templated protein acetylation transcription factor binding zinc ion binding acetyltransferase activity histone acetylation PML body nuclear speck myeloid cell differentiation histone H3 acetylation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated metal ion binding animal organ development MOZ/MORF histone acetyltransferase complex cellular senescence uc009led.1 uc009led.2 uc009led.3 
ENSMUST00000110700.2 Cdan1 ENSMUST00000110700.2 Cdan1 (from geneSymbol) AK157271 Cdan1 ENSMUST00000110700.1 Z4YL55 Z4YL55_MOUSE uc289zud.1 uc289zud.2 uc289zud.1 uc289zud.2 
ENSMUST00000110708.4 Srp54b ENSMUST00000110708.4 signal recognition particle 54B (from RefSeq NM_001100109.1) ENSMUST00000110708.1 ENSMUST00000110708.2 ENSMUST00000110708.3 NM_001100109 P14576 Q3UWX8 Q9CWH7 Q9D008 SRP54_MOUSE Srp54 uc007noh.1 uc007noh.2 uc007noh.3 Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). Interacts with RNPS1 (By similarity). Interacts with the SRP receptor subunit SRPRA (By similarity). Nucleus speckle Cytoplasm Endoplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14576-1; Sequence=Displayed; Name=2; IsoId=P14576-2; Sequence=VSP_014953, VSP_014954; The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity). The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins. Belongs to the GTP-binding SRP family. SRP54 subfamily. nucleotide binding RNA binding GTPase activity GTP binding nucleus cytoplasm signal recognition particle, endoplasmic reticulum targeting cytosol SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane, translocation drug binding 7S RNA binding nuclear speck GDP binding endoplasmic reticulum signal peptide binding ribonucleoprotein complex binding signal recognition particle nucleolus uc007noh.1 uc007noh.2 uc007noh.3 
ENSMUST00000110711.9 Snap23 ENSMUST00000110711.9 synaptosomal-associated protein 23, transcript variant 15 (from RefSeq NR_182013.1) ENSMUST00000110711.1 ENSMUST00000110711.2 ENSMUST00000110711.3 ENSMUST00000110711.4 ENSMUST00000110711.5 ENSMUST00000110711.6 ENSMUST00000110711.7 ENSMUST00000110711.8 NR_182013 O09044 O35620 SNP23_MOUSE Sndt uc008lwg.1 uc008lwg.2 uc008lwg.3 Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3 (By similarity). Found in a complex with VAMP8 and STX1A (By similarity). Found in a complex with VAMP8 and STX4 in pancreas (PubMed:15363411). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (PubMed:9507000). Interacts with STX12 (PubMed:9507000). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635). O09044; Q08850: Stx4; Xeno; NbExp=4; IntAct=EBI-1812522, EBI-918243; Cell membrane; Peripheral membrane protein. Cell membrane ; Lipid-anchor Synapse, synaptosome. Note=Mainly localized to the plasma membrane. Expressed in non-neuronal tissues. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type A (BoNT/A, botA) which hydrolyzes the 202-Thr-|-Arg-203 bond; the in vitro reaction is not highly efficient (PubMed:9886085). (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type E (BoNT/E) which hydrolyzes the 185-Arg-|-Ile-186 bond; the in vitro reaction is more efficient than that of BoNT/A (PubMed:9886085). Belongs to the SNAP-25 family. histamine secretion by mast cell SNAP receptor activity protein binding nucleoplasm cytoplasm plasma membrane cell-cell adherens junction exocytosis vesicle fusion protein transport membrane synaptic vesicle priming vesicle-mediated transport regulation of exocytosis syntaxin binding cell junction SNARE complex cytoplasmic vesicle synaptic vesicle fusion to presynaptic active zone membrane specific granule azurophil granule mast cell granule neuron projection synapse membrane fusion macromolecular complex assembly presynapse postsynapse exocytic insertion of neurotransmitter receptor to postsynaptic membrane glutamatergic synapse GABA-ergic synapse vesicle-mediated transport in synapse uc008lwg.1 uc008lwg.2 uc008lwg.3 
ENSMUST00000110717.9 Ankrd61 ENSMUST00000110717.9 ankyrin repeat domain 61, transcript variant 1 (from RefSeq NM_025732.4) ANR61_MOUSE ENSMUST00000110717.1 ENSMUST00000110717.2 ENSMUST00000110717.3 ENSMUST00000110717.4 ENSMUST00000110717.5 ENSMUST00000110717.6 ENSMUST00000110717.7 ENSMUST00000110717.8 NM_025732 Q80W77 Q9CQM6 uc009akv.1 uc009akv.2 uc009akv.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQM6-1; Sequence=Displayed; Name=2; IsoId=Q9CQM6-2; Sequence=VSP_032775; molecular_function DNA binding cellular_component biological_process uc009akv.1 uc009akv.2 uc009akv.3 
ENSMUST00000110731.4 Kdelr2 ENSMUST00000110731.4 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 (from RefSeq NM_025841.4) ENSMUST00000110731.1 ENSMUST00000110731.2 ENSMUST00000110731.3 ERD22_MOUSE NM_025841 Q4FK20 Q9CQM2 uc009akh.1 uc009akh.2 uc009akh.3 uc009akh.4 Membrane receptor that binds the K-D-E-L sequence motif in the C-terminal part of endoplasmic reticulum resident proteins and maintains their localization in that compartment by participating to their vesicle-mediated recycling back from the Golgi (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasmic vesicle, COPI-coated vesicle membrane ; Multi-pass membrane protein Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity). Belongs to the ERD2 family. Golgi membrane KDEL sequence binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cis-Golgi network protein retention in ER lumen ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER protein transport membrane integral component of membrane vesicle-mediated transport COPI-coated vesicle membrane cytoplasmic vesicle ER retention sequence binding uc009akh.1 uc009akh.2 uc009akh.3 uc009akh.4 
ENSMUST00000110733.9 Grid2ip ENSMUST00000110733.9 glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1, transcript variant 1 (from RefSeq NM_001159321.2) ENSMUST00000110733.1 ENSMUST00000110733.2 ENSMUST00000110733.3 ENSMUST00000110733.4 ENSMUST00000110733.5 ENSMUST00000110733.6 ENSMUST00000110733.7 ENSMUST00000110733.8 GRD2I_MOUSE NM_001159321 Q0QWG9 Q6DID0 Q9ESJ5 uc009akd.1 uc009akd.2 uc009akd.3 Postsynaptic scaffolding protein at the Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules. Interacts with C-terminus of the glutamate receptor GRID2 via PDZ domain. Isoform 2 interacts also with Profilin-2/PFN2 and with the monocarboxylate transporter SLC16A7 via PDZ domain. The interaction of isoform 2 with GRID2 is dependent on GRID2 phosphorylation by PKA. [Isoform 2]: Postsynaptic cell membrane. Cell projection, dendritic spine. Note=Localized to the postsynaptic junction site of the parallel fiber-Purkinje cell synapse. Highly present in the dendritic spines. [Isoform 3]: Synapse. Cell projection, dendritic spine. Cell membrane ; Lipid-anchor Note=Localized at the dendritic spines, but also in dendritic shafts apart fron spines. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=L-delphilin; IsoId=Q0QWG9-1; Sequence=Displayed; Name=2; Synonyms=S-delphilin, delphilin alpha; IsoId=Q0QWG9-2; Sequence=VSP_033275, VSP_033278; Name=3; Synonyms=delphilin beta; IsoId=Q0QWG9-3; Sequence=VSP_033276, VSP_033277; Isoform 1 is expressed in the cerebellum, but not in the cerebral cortex. Isoform 2 is expressed in the cell body of purkinge cells of the cerebellum and weakly expressed in the cerebrum and the brainstem as well as various nuclei of the thalamus. Isoform 2 is highly expressed in the cerebral cortex than in the cerebellum. Isoform 3 is expressed in the cerebellum and cerebrum. Isoform 3 expression is maintained throughout cerebellar development, while isoform 2 expression gradually decrease following the first postnatal week. PDZ 1 domain is responsible for cytoplasmic clustering of isoform 1. Isoform 2 is palmitoylated. Palmitoylation of isoform 2 is necessary for the enhanced cell surface expression of GRID2, and is also responsible for the accumulation of isoform 2 within dendritic spines. Isoform 1 and isoform 2 are differentially localized, probably modulating GRID2 signaling in neurons. Isoform 1 shows a punctate distribution throughout the cytoplasm when expressed in COS cells, whereas isoform 2 is enriched at the edges of the plasma membranes. When expressed in cultured hippocampal neurons, isoform 1 forms clusters mainly in the dendritic shafts, whereas isoform 2 is preferentially expressed in spines. [Isoform 1]: Not palmitoylated. [Isoform 2]: When Cys-3 is mutated to Ala-3, isoform 2 is not palmitoylated anymore. protein binding plasma membrane G-protein coupled glutamate receptor signaling pathway membrane actin cytoskeleton organization cell junction cell projection dendritic spine synapse postsynaptic membrane long term synaptic depression uc009akd.1 uc009akd.2 uc009akd.3 
ENSMUST00000110741.2 Fam90a1a ENSMUST00000110741.2 family with sequence similarity 90, member A1A (from RefSeq NM_001081662.1) A2A4E2 A2A4E2_MOUSE C86695 ENSMUST00000110741.1 Fam90a1a NM_001081662 uc009lch.1 uc009lch.2 Belongs to the FAM90 family. molecular_function cellular_component biological_process uc009lch.1 uc009lch.2 
ENSMUST00000110746.2 Gm43517 ENSMUST00000110746.2 Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. (from UniProt E9PYS1) AK042354 E9PYS1 E9PYS1_MOUSE ENSMUST00000110746.1 Gm43517 uc007nmg.1 uc007nmg.2 uc007nmg.3 Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. Nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc007nmg.1 uc007nmg.2 uc007nmg.3 
ENSMUST00000110748.4 Nrcam ENSMUST00000110748.4 neuronal cell adhesion molecule, transcript variant 2 (from RefSeq NM_001146031.1) ENSMUST00000110748.1 ENSMUST00000110748.2 ENSMUST00000110748.3 Kiaa0343 NM_001146031 NRCAM_MOUSE Q80U33 Q810U4 Q8BLG8 Q8BX92 Q8BYJ8 uc007nlv.1 uc007nlv.2 uc007nlv.3 uc007nlv.4 Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding (PubMed:11564762). Plays a role in mediating cell-cell contacts between Schwann cells and axons (PubMed:20188654). Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters (PubMed:14602817, PubMed:20188654). Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier (PubMed:24719088). Constituent of a NFASC/NRCAM/ankyrin-G complex (Probable). Detected in a complex with CNTN1 and PTPRB (PubMed:11564762). Interacts with GLDN/gliomedin and MYOC (PubMed:16039564, PubMed:23897819). Q810U4; Q811D0: Dlg1; NbExp=6; IntAct=EBI-8321816, EBI-514290; Q810U4; Q62108: Dlg4; NbExp=2; IntAct=EBI-8321816, EBI-300895; Cell membrane ; Single-pass type I membrane protein Cell projection, axon Secreted Note=Detected at nodes of Ranvier (PubMed:14602817, PubMed:20188654, PubMed:24719088). Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q810U4-1; Sequence=Displayed; Name=2; IsoId=Q810U4-2; Sequence=VSP_008926, VSP_008927; Name=3; IsoId=Q810U4-3; Sequence=VSP_008930; Name=4; IsoId=Q810U4-4; Sequence=VSP_008923, VSP_008925; Name=5; IsoId=Q810U4-5; Sequence=VSP_008921, VSP_008922, VSP_008924; Detected in sciatic nerve (PubMed:14602817, PubMed:20188654, PubMed:24719088). Detected in brain, especially in the cerebellum Purkinje cell layer, inner granule cell layer and molecular layer (at protein level) (PubMed:11564762). Detected in neurons and Schwann cells (PubMed:20188654). Mice are born at the expected Mendelian rate, are viable and fertile. They present no obvious phenotype excepting subtle size differences of cerebellar lobes IV and V. Contrary to wild-type, cerebellar cells do not form neurites when plated on a surface coated with contactin (in vitro) (PubMed:11564762). Neonates present delayed formation of sodium channel clusters at developing nodes of Ranvier, but are indistiguishable from wild-type at 10 days after birth (PubMed:14602817, PubMed:20188654). Mice lacking both Gldn and Nrcam are born at the expected Mendelian rate, but are smaller than control littermates and display important neurological impairments, in spite of seemingly normal nerve myelination. Motor abnormalities vary between individuals, ranging from ataxia, uncoordinated movements and premature death to weakness of the hind limbs, hypomotility, strongly impaired ability to hang from a horizontal bar with their forelimbs and a tendency to stumble. The motor defects correlate with decreased velocity of nerve conduction and slower propagation of action potentials. Most mice die within 60 days after birth, and none are fertile. Mutant mice display delayed formation of mature nodes of Ranvier; 15 days after birth about 20% of the nodes lack detectable sodium channel clusters. Sodium channel clustering and nerve conduction appear normal 60 and 75 days after birth, but subsequently a gradual disintegration of the nodal protein complexes is seen. About 70% of the mutant nodes present high-density sodium channel clustering at 120 days after birth, as opposed to nearly 100% for wild-type. Contrary to wild- type, in adult nodes of Ranvier the sodium channels are often clustered near the paranode border with an empty gap in the middle. At nodes of Ranvier, Schwann cell microvilli are sparse or absent and show defects in their orientation, resulting in various structural abnormalities at the node and the paranode border (PubMed:24719088). Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. Sequence=BAC65534.1; Type=Erroneous initiation; Evidence=; Sequence=CAD65848.1; Type=Erroneous initiation; Evidence=; angiogenesis protein binding extracellular region plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules axon guidance central nervous system development protein localization regulation of neuron projection development membrane integral component of membrane neuronal action potential propagation axon ankyrin binding retinal ganglion cell axon guidance node of Ranvier heterotypic cell-cell adhesion cell projection axon initial segment clustering of voltage-gated sodium channels synapse dendrite self-avoidance protein binding involved in heterotypic cell-cell adhesion cell-cell adhesion protein binding involved in cell-cell adhesion glutamatergic synapse integral component of postsynaptic membrane integral component of postsynaptic density membrane uc007nlv.1 uc007nlv.2 uc007nlv.3 uc007nlv.4 
ENSMUST00000110749.4 Defa43 ENSMUST00000110749.4 defensin, alpha, 43 (from RefSeq NM_001177526.1) D3YX03 D3YX03_MOUSE Defa42 Defa43 ENSMUST00000110749.1 ENSMUST00000110749.2 ENSMUST00000110749.3 Gm7849 Gm7861 NM_001177526 uc012gaz.1 uc012gaz.2 uc012gaz.3 uc012gaz.4 Secreted innate immune response in mucosa molecular_function cellular_component extracellular region extracellular space defense response biological_process antibacterial humoral response defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc012gaz.1 uc012gaz.2 uc012gaz.3 uc012gaz.4 
ENSMUST00000110752.4 Defa42 ENSMUST00000110752.4 defensin, alpha, 42 (from RefSeq NM_001177518.1) D3YX03 D3YX03_MOUSE Defa42 Defa43 ENSMUST00000110752.1 ENSMUST00000110752.2 ENSMUST00000110752.3 Gm7849 Gm7861 NM_001177518 uc012gaw.1 uc012gaw.2 uc012gaw.3 Secreted innate immune response in mucosa molecular_function cellular_component extracellular region extracellular space defense response biological_process antibacterial humoral response defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc012gaw.1 uc012gaw.2 uc012gaw.3 
ENSMUST00000110754.2 Defa41 ENSMUST00000110754.2 defensin, alpha, 41 (from RefSeq NM_001177486.1) D3YX02 D3YX02_MOUSE Defa41 ENSMUST00000110754.1 Gm15293 NM_001177486 uc012gat.1 uc012gat.2 uc012gat.3 Secreted Belongs to the alpha-defensin family. innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc012gat.1 uc012gat.2 uc012gat.3 
ENSMUST00000110758.4 AY761185 ENSMUST00000110758.4 cDNA sequence AY761185 (from RefSeq NM_001012640.2) AY761185 ENSMUST00000110758.1 ENSMUST00000110758.2 ENSMUST00000110758.3 NM_001012640 Q5ERI8 Q5ERI8_MOUSE uc009lbi.1 uc009lbi.2 uc009lbi.3 uc009lbi.4 Secreted innate immune response in mucosa molecular_function extracellular region extracellular space defense response antibacterial humoral response defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc009lbi.1 uc009lbi.2 uc009lbi.3 uc009lbi.4 
ENSMUST00000110763.2 Defb5 ENSMUST00000110763.2 defensin beta 5 (from RefSeq NM_030734.3) DEFB5_MOUSE ENSMUST00000110763.1 F8VQA5 NM_030734 Q9EPV9 uc009lan.1 uc009lan.2 uc009lan.3 Has antibacterial activity. Secreted Belongs to the beta-defensin family. extracellular region extracellular space chemotaxis defense response CCR6 chemokine receptor binding chemoattractant activity defense response to bacterium positive chemotaxis cell chemotaxis uc009lan.1 uc009lan.2 uc009lan.3 
ENSMUST00000110778.2 Wipi2 ENSMUST00000110778.2 Preautophagosomal structure membrane ; Peripheral membrane protein ; Cytoplasmic side (from UniProt D3YWK1) BC044894 D3YWK1 D3YWK1_MOUSE ENSMUST00000110778.1 Wipi2 uc291bkb.1 uc291bkb.2 Preautophagosomal structure membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the WD repeat PROPPIN family. autophagosome assembly pre-autophagosomal structure autophagy phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,5-bisphosphate binding uc291bkb.1 uc291bkb.2 
ENSMUST00000110793.8 Rpap1 ENSMUST00000110793.8 Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity). (from UniProt Q80TE0) A2AQ24 AK122505 ENSMUST00000110793.1 ENSMUST00000110793.2 ENSMUST00000110793.3 ENSMUST00000110793.4 ENSMUST00000110793.5 ENSMUST00000110793.6 ENSMUST00000110793.7 Kiaa1403 Q148U0 Q148U1 Q3TJ48 Q3TLZ5 Q3TTA6 Q80TE0 Q80UT8 Q91VM0 RPAP1_MOUSE uc289zps.1 uc289zps.2 Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity). Part of an RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and TFIIF. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80TE0-1; Sequence=Displayed; Name=2; IsoId=Q80TE0-2; Sequence=VSP_024682, VSP_024683; Belongs to the RPAP1 family. Sequence=BAC65787.1; Type=Erroneous initiation; Evidence=; DNA binding DNA-directed 5'-3' RNA polymerase activity nucleus transcription from RNA polymerase II promoter transferase activity nucleotidyltransferase activity RNA polymerase complex uc289zps.1 uc289zps.2 
ENSMUST00000110813.5 Erich1 ENSMUST00000110813.5 glutamate rich 1 (from RefSeq NM_001034862.2) E9PY43 E9PY43_MOUSE ENSMUST00000110813.1 ENSMUST00000110813.2 ENSMUST00000110813.3 ENSMUST00000110813.4 Erich1 NM_001034862 uc009kyx.1 uc009kyx.2 uc009kyx.3 molecular_function cellular_component biological_process uc009kyx.1 uc009kyx.2 uc009kyx.3 
ENSMUST00000110832.8 Tmem184a ENSMUST00000110832.8 transmembrane protein 184a, transcript variant 2 (from RefSeq NM_144914.3) ENSMUST00000110832.1 ENSMUST00000110832.2 ENSMUST00000110832.3 ENSMUST00000110832.4 ENSMUST00000110832.5 ENSMUST00000110832.6 ENSMUST00000110832.7 NM_144914 Q3UFJ6 Q8BII8 Q8K1B0 Sdmg1 T184A_MOUSE uc009ahe.1 uc009ahe.2 uc009ahe.3 uc009ahe.4 Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (PubMed:18321981, PubMed:19097053). Cell membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region Cytoplasmic vesicle membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Endosome Cytoplasmic vesicle, secretory vesicle membrane Note=Colocalizes with the secretory granule marker VAMP2 in pancreatic acinar cells (PubMed:19097053). Expressed in testis, pancreas, parotid salivary gland and mammary gland (at protein level)(PubMed:17616727, PubMed:19097053). Up-regulated in the testes from 11.5 dpc until 16.5 dpc, expression is maintained in the male Sertoli cells throughout embryonic development and into adulthood. Not expressed in the female gonad during embryonic development (PubMed:17616727, PubMed:18321981). Expressed in the granulosa cells, a few days after birth, expression is maintained in granulosa cells during folliculogenesis (PubMed:17616727, PubMed:18321981). Up-regulated during embryonic pancreatic acinar cell differentiation (PubMed:19097053). Belongs to the TMEM184 family. Sequence=BAC34286.1; Type=Erroneous initiation; Evidence=; cytoplasm endosome plasma membrane heparin binding membrane integral component of membrane germ-line sex determination transport vesicle membrane cytoplasmic vesicle membrane secretory granule membrane cytoplasmic vesicle early endosome membrane regulation of protein localization perinuclear region of cytoplasm regulation of secretion uc009ahe.1 uc009ahe.2 uc009ahe.3 uc009ahe.4 
ENSMUST00000110844.3 Kcnh1 ENSMUST00000110844.3 potassium voltage-gated channel, subfamily H (eag-related), member 1, transcript variant 2 (from RefSeq NM_001038607.3) ENSMUST00000110844.1 ENSMUST00000110844.2 Kcnh1 NM_001038607 Q3UHC9 Q3UHC9_MOUSE uc007edn.1 uc007edn.2 uc007edn.3 uc007edn.4 Membrane ; Multi- pass membrane protein ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity integral component of plasma membrane ion transport potassium ion transport membrane integral component of membrane regulation of ion transmembrane transport transmembrane transport potassium ion transmembrane transport uc007edn.1 uc007edn.2 uc007edn.3 uc007edn.4 
ENSMUST00000110855.8 Lpgat1 ENSMUST00000110855.8 lysophosphatidylglycerol acyltransferase 1, transcript variant 2 (from RefSeq NM_172266.4) ENSMUST00000110855.1 ENSMUST00000110855.2 ENSMUST00000110855.3 ENSMUST00000110855.4 ENSMUST00000110855.5 ENSMUST00000110855.6 ENSMUST00000110855.7 Fam34a LGAT1_MOUSE Lpgat1 NM_172266 Q91YX5 uc007ecs.1 uc007ecs.2 uc007ecs.3 uc007ecs.4 uc007ecs.5 uc007ecs.6 Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (PubMed:35131264). Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor (PubMed:36049524). Acts in concert with an unknown phospholipase A1 to convert palmitate PE species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (PubMed:35131264). Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors (By similarity). Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (PubMed:20018982, PubMed:35131264). Has no activity toward lysophosphatidic acids (LPA) and lysophosphatidylcholines (LPC) (PubMed:35131264). Reaction=a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:70583, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:65213, ChEBI:CHEBI:189703; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70584; Evidence=; Reaction=2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + CoA; Xref=Rhea:RHEA:70579, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:75038, ChEBI:CHEBI:76088; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70580; Evidence=; Reaction=a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:70595, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:65213, ChEBI:CHEBI:77370; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70596; Evidence=; Reaction=2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + CoA; Xref=Rhea:RHEA:70591, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:73007, ChEBI:CHEBI:76088; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70592; Evidence=; Reaction=1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3- phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35855, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72826, ChEBI:CHEBI:72830; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35856; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho- (1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:40107, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:75158, ChEBI:CHEBI:77001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40108; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn- glycerol) + CoA; Xref=Rhea:RHEA:35851, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72829, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35852; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3- phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35887, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:72839, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35888; Evidence=; Reaction=1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3- phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35859, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72827, ChEBI:CHEBI:72831; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35860; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3- phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:40099, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:72828, ChEBI:CHEBI:77000; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40100; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho- (1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35891, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72841, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35892; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3- phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35863, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72828, ChEBI:CHEBI:72832; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35864; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phospho-(1'-sn-glycerol) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37651, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72828, ChEBI:CHEBI:75163; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37652; Evidence=; Reaction=a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA; Xref=Rhea:RHEA:16741, ChEBI:CHEBI:17389, ChEBI:CHEBI:49172, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; EC=2.3.1.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16742; Evidence=; Reaction=a 2-acylglycerol + hexadecanoyl-CoA = a 1-hexadecanoyl-2- acylglycerol + CoA; Xref=Rhea:RHEA:65096, ChEBI:CHEBI:17389, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:156324; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65097; Evidence=; Reaction=a 1-acylglycerol + hexadecanoyl-CoA = an hexadecanoyl- acylglycerol + CoA; Xref=Rhea:RHEA:65100, ChEBI:CHEBI:35759, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:156325; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65101; Evidence=; Reaction=a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2- diacyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:10332, ChEBI:CHEBI:57287, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875, ChEBI:CHEBI:58342; EC=2.3.1.62; Evidence=; Reaction=2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:74799, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:75034, ChEBI:CHEBI:76071; Evidence=; Reaction=2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn- glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:74803, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:76084, ChEBI:CHEBI:84822; Evidence=; Reaction=2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:74807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:74965, ChEBI:CHEBI:76079; Evidence=; Reaction=2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:74811, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:73001, ChEBI:CHEBI:76071; Evidence=; Reaction=2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phospho-L-serine + CoA; Xref=Rhea:RHEA:74815, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75029, ChEBI:CHEBI:77342; Evidence=; Reaction=2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3- phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2- (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:74823, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:76085, ChEBI:CHEBI:84829; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3- phospho-L-serine + CoA; Xref=Rhea:RHEA:37403, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:74617, ChEBI:CHEBI:74902; Evidence=; Reaction=a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:70599, ChEBI:CHEBI:57287, ChEBI:CHEBI:64612, ChEBI:CHEBI:65213, ChEBI:CHEBI:77636; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70600; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Ubiquitous. Expressed in heart, kidney, liver, skin, intestine, and thymus. Highest expression is detected in brain and testis. The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. Mice are born at the expected Mendelian frequency. They show reduced body fat and increased mortality during early adulthood with an average life span of about 5 months. Mutant mice produce poorly nutritional milk and are unable to nourish their litters leading in high pre-weaning mortality. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. The role in phosphatidylglycerols remodeling and cardiolipin synthesis is questioned as both processes occur in mitochondria. The monoacylglycerol acyltransferase activity is also weak and a direct role in triacylglycerol synthesis appears unlikely. molecular_function cellular_component cytoplasm endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process biological_process phospholipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups phosphatidylinositol acyl-chain remodeling positive regulation of fatty acid biosynthetic process uc007ecs.1 uc007ecs.2 uc007ecs.3 uc007ecs.4 uc007ecs.5 uc007ecs.6 
ENSMUST00000110857.5 Dld ENSMUST00000110857.5 dihydrolipoamide dehydrogenase (from RefSeq NM_007861.5) DLDH_MOUSE ENSMUST00000110857.1 ENSMUST00000110857.2 ENSMUST00000110857.3 ENSMUST00000110857.4 NM_007861 O08749 Q3TG55 Q3U5W5 Q3UWP7 Q99LD3 uc007nhg.1 uc007nhg.2 uc007nhg.3 uc007nhg.4 uc007nhg.5 This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. [provided by RefSeq, Jan 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.142418.1, SRR1660815.257761.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta multifunctional gene product(s) :: PMID: 17404228 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex) (By similarity). The 2- oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). Reaction=N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH; Xref=Rhea:RHEA:15045, Rhea:RHEA-COMP:10474, Rhea:RHEA-COMP:10475, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83099, ChEBI:CHEBI:83100; EC=1.8.1.4; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Homodimer. Part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (subunits PDHA (PDHA1 or PDHA2) and PDHB, E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (by non covalent bonds). The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2), DLD (dihydrolipoamide dehydrogenase; E3) and the assembly factor KGD4 (PubMed:36854377). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A. Interacts with PDHX. O08749; O54910: Nfkbie; NbExp=4; IntAct=EBI-773199, EBI-6688774; Mitochondrion matrix Nucleus Cell projection, cilium, flagellum Cytoplasmic vesicle, secretory vesicle, acrosome Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2- oxoglutarate dehydrogenase complex is required for histone succinylation. Expressed in liver (at protein level). Tyrosine phosphorylated. The active site is a redox-active disulfide bond. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. acrosomal vesicle dihydrolipoyl dehydrogenase activity protein binding nucleus nucleoplasm mitochondrion mitochondrial matrix cilium acetyl-CoA biosynthetic process from pyruvate 2-oxoglutarate metabolic process mitochondrial electron transport, NADH to ubiquinone proteolysis gastrulation aging electron carrier activity lipoate metabolic process oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor cytoplasmic vesicle motile cilium pyruvate dehydrogenase (NAD+) activity regulation of membrane potential cell projection acrosomal matrix myelin sheath lipoamide binding oxoglutarate dehydrogenase complex pyruvate dehydrogenase complex cell redox homeostasis sperm capacitation flavin adenine dinucleotide binding dihydrolipoamide metabolic process NAD binding oxidation-reduction process mitochondrial acetyl-CoA biosynthetic process from pyruvate uc007nhg.1 uc007nhg.2 uc007nhg.3 uc007nhg.4 uc007nhg.5 
ENSMUST00000110865.2 Adap1 ENSMUST00000110865.2 ArfGAP with dual PH domains 1 (from RefSeq NM_172723.4) Adap1 E9PY16 E9PY16_MOUSE ENSMUST00000110865.1 NM_172723 uc009agi.1 uc009agi.2 uc009agi.3 GTPase activator activity phosphatidylinositol-3,4,5-trisphosphate binding nucleus cytoplasm cytosol plasma membrane regulation of GTPase activity positive regulation of GTPase activity metal ion binding phosphatidylinositol bisphosphate binding uc009agi.1 uc009agi.2 uc009agi.3 
ENSMUST00000110879.9 Mcf2l ENSMUST00000110879.9 mcf.2 transforming sequence-like, transcript variant 7 (from RefSeq NM_001371046.1) E9PXE1 E9PXE1_MOUSE ENSMUST00000110879.1 ENSMUST00000110879.2 ENSMUST00000110879.3 ENSMUST00000110879.4 ENSMUST00000110879.5 ENSMUST00000110879.6 ENSMUST00000110879.7 ENSMUST00000110879.8 Mcf2l NM_001371046 uc291yhb.1 uc291yhb.2 Cytoplasm guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity regulation of Rho protein signal transduction intracellular signal transduction uc291yhb.1 uc291yhb.2 
ENSMUST00000110882.8 Sun1 ENSMUST00000110882.8 Sad1 and UNC84 domain containing 1, transcript variant 5 (from RefSeq NM_001256118.1) D3Z0V9 ENSMUST00000110882.1 ENSMUST00000110882.2 ENSMUST00000110882.3 ENSMUST00000110882.4 ENSMUST00000110882.5 ENSMUST00000110882.6 ENSMUST00000110882.7 NM_001256118 Q3TIW3 Q3TV96 Q6B4H0 Q80SU8 Q8BZ99 Q99P23 Q9D666 SUN1_MOUSE Sun1 Unc84a uc291ber.1 uc291ber.2 As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:20711465, PubMed:16380439, PubMed:24062341, PubMed:25892231, PubMed:26842404). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:19874786). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (PubMed:19874786). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (PubMed:17543860, PubMed:19211677, PubMed:19509342, PubMed:24062341, PubMed:25892231, PubMed:26842404). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (PubMed:17543860). Helps to define the distribution of nuclear pore complexes (NPCs) (PubMed:17724119). Required for efficient localization of SYNE4 in the nuclear envelope (PubMed:23348741). May be involved in nuclear remodeling during sperm head formation in spermatogenesis (PubMed:20711465). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (By similarity). Isoform 5 may be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN1 isoform 5:SYNE3 LINC complex may tether spermatid nuclei to anterior cytoskeletal structures such as actin filaments present at membraneous junctions of spermatids and Sertoli cells. Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain- containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents is giving rise to specific assemblies. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain-containing protein. Interacts with KASH5 (via the last 22 amino acids); this interaction mediates KASH5 telomere localization by forming a SUN1:KASH5 LINC complex. Isoform 5 is proposed to form a non-nuclear spermatogenesis-specific LINC complex with SYNE3 during sperm head formation. Interacts with SYNE2 and SYNE1; probably forming respective LINC complexes. Interacts with A-type lamin with a strong preference for unprocessed A-type lamin compared with the mature protein. Interaction with lamins B1 and C is hardly detectable. Interacts with NAT10. Interacts with EMD and TSNAX. Associates with the nuclear pore complex (NPC). Interacts with CCDC79/TERB1; promoting the accumulation of the LINC complex complexes at the telomere-nuclear envelope attachment sites. Interacts with IRAG2 (PubMed:29878215). Interacts (via KASH domain) with TMEM258 (By similarity). Q9D666; Q80VJ8: Kash5; NbExp=4; IntAct=EBI-6752574, EBI-11666341; Q9D666; Q8C0V1: Terb1; NbExp=2; IntAct=EBI-6752574, EBI-11707325; Q9D666; P50402: EMD; Xeno; NbExp=4; IntAct=EBI-6752574, EBI-489887; Q9D666; Q8WXH0-4: SYNE2; Xeno; NbExp=2; IntAct=EBI-6752574, EBI-6838657; Nucleus inner membrane ingle-pass type II membrane protein te=At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles. In round spermatids mainly localizes to the posterior pole of the nucleus. This localization is gradually disappearing during spermiogenesis. In elongated spermatids localizes to anterior regions outside the nucleus indicative for isoform 5. [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane Note=Localized to the anterior pole of spermatids. Event=Alternative splicing; Named isoforms=5; Comment=Seven isoforms have been found to be expressed.; Name=1; Synonyms=alpha; IsoId=Q9D666-1; Sequence=Displayed; Name=2; Synonyms=zeta; IsoId=Q9D666-2; Sequence=VSP_009346; Name=3; Synonyms=beta; IsoId=Q9D666-3; Sequence=VSP_009347; Name=4; Synonyms=delta; IsoId=Q9D666-4; Sequence=VSP_039552; Name=5; Synonyms=eta; IsoId=Q9D666-5; Sequence=VSP_058699; Widely expressed. Expressed in cochlear outer hair cells (at protein level). Seven isoforms are expressed in testis including testis-specific isoform 5. Isoform 5 is the only isoform expressed at the end of sperm differentiation. Six isoforms are expressed in muscle, heart and brain, four isoforms in kidney and three isoforms in liver. The coiled coil domains differentially mediate trimerization required for binding to nesprins and are proposed to dynamically regulate the oligomeric state by locking the SUN domain in an inactive confirmation. The coiled coil domains are proposed to be involved in load-bearing and force transmission from the cytoskeleton. The SUN domain may play a role in nuclear anchoring and/or migration. The disulfide bond with KASH domain-containing nesprins is required for stability of the respective LINC complexes under tensile forces. Mutant mice are viable, but display hearing loss at all frequencies. Sequence=AAH30330.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; ossification acrosomal membrane outer acrosomal membrane protein binding lamin binding nucleus nuclear envelope nuclear inner membrane integral component of nuclear inner membrane cytoplasm nuclear envelope organization synapsis spermatogenesis response to mechanical stimulus membrane integral component of membrane nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration cell differentiation cytoplasmic vesicle nuclear membrane LINC complex intracellular membrane-bounded organelle protein anchor meiotic cell cycle centrosome localization meiotic attachment of telomere to nuclear envelope cytoskeletal anchoring at nuclear membrane nuclear matrix anchoring at nuclear membrane nucleolus uc291ber.1 uc291ber.2 
ENSMUST00000110890.8 Prkar1b ENSMUST00000110890.8 protein kinase, cAMP dependent regulatory, type I beta, transcript variant 6 (from RefSeq NM_001359100.1) ENSMUST00000110890.1 ENSMUST00000110890.2 ENSMUST00000110890.3 ENSMUST00000110890.4 ENSMUST00000110890.5 ENSMUST00000110890.6 ENSMUST00000110890.7 KAP1_MOUSE NM_001359100 P12849 uc029vpr.1 uc029vpr.2 uc029vpr.3 Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKX; regulates this cAMP-dependent protein kinase (By similarity). Interacts with smAKAP; this interaction may target PRKAR1B to the plasma membrane (By similarity). Cell membrane Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity. Belongs to the cAMP-dependent kinase regulatory chain family. nucleotide binding regulation of protein phosphorylation cAMP-dependent protein kinase inhibitor activity cytoplasm cytosol plasma membrane cAMP-dependent protein kinase complex protein phosphorylation learning or memory cAMP-dependent protein kinase regulator activity animal organ morphogenesis membrane cGMP-mediated signaling cAMP binding protein kinase A catalytic subunit binding synapse regulation of protein kinase activity 3',5'-cyclic-GMP phosphodiesterase activity modulation of synaptic transmission glutamatergic synapse negative regulation of cAMP-dependent protein kinase activity uc029vpr.1 uc029vpr.2 uc029vpr.3 
ENSMUST00000110893.10 Tatdn3 ENSMUST00000110893.10 TatD DNase domain containing 3, transcript variant 1 (from RefSeq NM_026895.1) E9QL22 E9QL22_MOUSE ENSMUST00000110893.1 ENSMUST00000110893.2 ENSMUST00000110893.3 ENSMUST00000110893.4 ENSMUST00000110893.5 ENSMUST00000110893.6 ENSMUST00000110893.7 ENSMUST00000110893.8 ENSMUST00000110893.9 NM_026895 Tatdn3 uc007eby.1 uc007eby.2 uc007eby.3 uc007eby.4 Putative deoxyribonuclease. Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. hydrolase activity, acting on ester bonds uc007eby.1 uc007eby.2 uc007eby.3 uc007eby.4 
ENSMUST00000110894.9 Tpt1 ENSMUST00000110894.9 tumor protein, translationally-controlled 1, transcript variant 1 (from RefSeq NM_009429.4) ENSMUST00000110894.1 ENSMUST00000110894.2 ENSMUST00000110894.3 ENSMUST00000110894.4 ENSMUST00000110894.5 ENSMUST00000110894.6 ENSMUST00000110894.7 ENSMUST00000110894.8 NM_009429 P14701 P63028 Q3TMT0 Q3TWS8 Q3TWX0 Q3UAG7 Q569M9 TCTP_MOUSE Trt uc007uqz.1 uc007uqz.2 uc007uqz.3 uc007uqz.4 Involved in calcium binding and microtubule stabilization (By similarity). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (By similarity). Homodimer (By similarity). Interacts with STEAP3 (By similarity). Interacts with TSC22D1; interaction results in the destabilization of TSC22D1 protein (By similarity). P63028; P09405: Ncl; NbExp=4; IntAct=EBI-1635228, EBI-641864; Cytoplasm Preferentially synthesized in cells of the early growth phase of Ehrlich ascites tumor. Belongs to the TCTP family. spindle pole calcium ion binding protein binding extracellular space nucleus nucleoplasm cytoplasm multivesicular body cytosol cytoplasmic microtubule spermatogenesis transcription factor binding stem cell population maintenance negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of ectoderm development uc007uqz.1 uc007uqz.2 uc007uqz.3 uc007uqz.4 
ENSMUST00000110896.2 Pdgfa ENSMUST00000110896.2 platelet derived growth factor, alpha, transcript variant 5 (from RefSeq NM_001422139.1) ENSMUST00000110896.1 NM_001422139 Pdgfa Q99L56 Q99L56_MOUSE uc291bdr.1 uc291bdr.2 Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4. Secreted Belongs to the PDGF/VEGF growth factor family. platelet-derived growth factor receptor binding collagen binding extracellular space growth factor activity positive regulation of cell proliferation response to wounding cell surface negative regulation of phosphatidylinositol biosynthetic process negative regulation of platelet activation positive regulation of phosphatidylinositol 3-kinase signaling regulation of smooth muscle cell migration membrane positive regulation of cell migration positive regulation of protein autophosphorylation positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway protein homodimerization activity positive regulation of MAP kinase activity positive regulation of MAPK cascade protein heterodimerization activity platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation platelet-derived growth factor binding negative chemotaxis positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade uc291bdr.1 uc291bdr.2 
ENSMUST00000110905.9 Zfp68 ENSMUST00000110905.9 zinc finger protein 68, transcript variant 1 (from RefSeq NM_013844.2) ENSMUST00000110905.1 ENSMUST00000110905.2 ENSMUST00000110905.3 ENSMUST00000110905.4 ENSMUST00000110905.5 ENSMUST00000110905.6 ENSMUST00000110905.7 ENSMUST00000110905.8 KRAZ2 NM_013844 Q9Z116 Q9Z116_MOUSE Zfp68 uc009afq.1 uc009afq.2 uc009afq.3 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009afq.1 uc009afq.2 uc009afq.3 
ENSMUST00000110907.8 Meis2 ENSMUST00000110907.8 Meis homeobox 2, transcript variant 14 (from RefSeq NM_001346053.1) ENSMUST00000110907.1 ENSMUST00000110907.2 ENSMUST00000110907.3 ENSMUST00000110907.4 ENSMUST00000110907.5 ENSMUST00000110907.6 ENSMUST00000110907.7 MEIS2_MOUSE Mrg1 NM_001346053 O35676 O35677 P97367 P97403 P97404 Stra10 uc008lqw.1 uc008lqw.2 uc008lqw.3 uc008lqw.4 This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcriptional regulators and several members have been shown to be essential contributors to developmental programs. In mice, a knock-out of this gene leads to lethality at embryonic day 14, accompanied with hemorrhaging. Embryos lacking this gene show defects in tissues derived from the neural crest, suggesting a critical role of this gene during cranial and cardiac neural crest cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoforms Meis2B and Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription. Monomer and homodimer. Heterodimer with HOXB13 (By similarity). Isoform Meis2A interacts with TLX1. Isoform Meis2B interacts with HOXA13 and PBX1 isoform PBX1b. Isoform Meis2D interacts with SP1, SP3 and KLF4. Isoform Meis2D interacts with PBX1 isoform PBX1a; the interaction partially relieves MEIS2 autoinhibition. Isoform Meis2B is part of a PDX1:PBX1b:MEIS2b complex; Meis2B is recruited by PBX1b and can be replaced by isoform Meis2D in a small fraction of complexes. Can form trimeric complexes including HOXB8 and PBX2 or PBX3. Nucleus toplasm, perinuclear region Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=Meis2C; IsoId=P97367-1; Sequence=Displayed; Name=Meis2A; IsoId=P97367-2; Sequence=VSP_002248, VSP_002249; Name=Meis2B; Synonyms=Mrg1A; IsoId=P97367-3; Sequence=VSP_002247, VSP_002248, VSP_002249; Name=Meis2D; Synonyms=Mrg1B; IsoId=P97367-4; Sequence=VSP_002247; Displays spatially restricted expression patterns in the developing nervous system, limbs, face, and in various viscera. In adult, it is mainly expressed in the brain and female genital tract, with a different distribution of the alternative splice forms in these organs. Lower expression in lung and only basal level in heart, liver, kidney, spleen, and testis. Expressed in pancreatic islets (beta-cells only) (PubMed:21059917). Expressed at high levels in all stages of embryonic development analyzed (7 days to 17 days). First detected around 10.5 dpc in the developing ventrolateral telencephalon. Is found at moderate levels throughout the ventricle zone (VZ) of the entire telencephalon with the exception of the ventro- and dorso-medial regions. The highest expression is detected in the subventricular zone (SVZ) of the lateral ganglionic eminence (LGE) and developing striatum. By 16.5 dpc, also found in the cortical plate. Also expressed at high levels in the caudal ganglionic eminence (CGE) and amygdala. Expression in the telencephalon remains unchanged at birth and into adulthood. By retinoic acid. Belongs to the TALE/MEIS homeobox family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding eye development DNA binding transcription cofactor activity nucleus cytoplasm regulation of transcription, DNA-templated multicellular organism development transcription factor binding visual learning response to mechanical stimulus pancreas development sequence-specific DNA binding negative regulation of myeloid cell differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm response to growth factor uc008lqw.1 uc008lqw.2 uc008lqw.3 uc008lqw.4 
ENSMUST00000110909.9 Arhgef7 ENSMUST00000110909.9 Rho guanine nucleotide exchange factor, transcript variant 5 (from RefSeq NM_001372322.1) ARHG7_MOUSE ENSMUST00000110909.1 ENSMUST00000110909.2 ENSMUST00000110909.3 ENSMUST00000110909.4 ENSMUST00000110909.5 ENSMUST00000110909.6 ENSMUST00000110909.7 ENSMUST00000110909.8 Kiaa0142 NM_001372322 O08757 Pak3bp Q3UTS5 Q6XPA5 Q6ZQI5 Q8C750 Q91ZZ6 Q9ES27 Q9ES28 uc009kvv.1 uc009kvv.2 uc009kvv.3 uc009kvv.4 Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). Interacts with PAK kinases through the SH3 domain. Interacts with unphosphorylated PAK1. Interacts with ITCH. Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis (By similarity). Interacts with GIT1 and TGFB1I1. Interacts with FRMPD4 (via N-terminus). Interacts with CaMK1. Interacts with BIN2 (By similarity). Interacts with PTK2/FAK1 and RAC1. Interacts with PARVB. Interacts with YWHAZ (PubMed:16959763). Interacts (via PH domain) with NOX1 (via FAD-binding FR-type domain) (By similarity). Q9ES28; Q68FF6: Git1; NbExp=2; IntAct=EBI-642580, EBI-645933; Q9ES28; Q9JLQ2: Git2; NbExp=6; IntAct=EBI-642580, EBI-642860; Q9ES28; Q9ES46: Parvb; NbExp=2; IntAct=EBI-642580, EBI-6914996; Q9ES28; Q9Z272: Git1; Xeno; NbExp=2; IntAct=EBI-642580, EBI-3842379; Q9ES28; Q14161: GIT2; Xeno; NbExp=2; IntAct=EBI-642580, EBI-1046878; Q9ES28; Q9HBI1: PARVB; Xeno; NbExp=10; IntAct=EBI-642580, EBI-1047679; Q9ES28; Q9QX74-4: Shank2; Xeno; NbExp=3; IntAct=EBI-642580, EBI-36481413; Q9ES28-2; Q9WV48: Shank1; Xeno; NbExp=6; IntAct=EBI-8620514, EBI-80909; Q9ES28-2; Q9QX74: Shank2; Xeno; NbExp=4; IntAct=EBI-8620514, EBI-397902; Q9ES28-2; Q9JLU4: Shank3; Xeno; NbExp=2; IntAct=EBI-8620514, EBI-6271152; Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection, lamellipodium. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions. Event=Alternative splicing, Alternative initiation; Named isoforms=8; Name=B; IsoId=Q9ES28-1; Sequence=Displayed; Name=A; IsoId=Q9ES28-2; Sequence=VSP_001817; Name=C; IsoId=Q9ES28-3; Sequence=VSP_001816; Name=D; IsoId=Q9ES28-4; Sequence=VSP_023052, VSP_023053, VSP_001817; Name=E; Synonyms=d; IsoId=Q9ES28-5; Sequence=VSP_023055, VSP_023057; Name=F; IsoId=Q9ES28-6; Sequence=VSP_023052, VSP_023053, VSP_023054, VSP_023056; Name=G; Synonyms=b(L); IsoId=Q9ES28-7; Sequence=VSP_023052, VSP_023053; Name=H; Synonyms=b; IsoId=Q9ES28-8; Sequence=VSP_023051; Seems to be expressed in the central nervous system. Isoform B, isoform C and isoform E are expressed with highest levels in brain and testis. Phosphorylated on Ser-673 by CaMK1; enhancement of GEF activity and downstream activation of RAC1 (By similarity). Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1. [Isoform H]: Produced by alternative initiation at Met- 158 of isoform G. Sequence=AAB57691.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAG18017.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAG18018.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH44838.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAK97363.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC35033.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC97874.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; storage vacuole ruffle hematopoietic progenitor cell differentiation guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding cytoplasm cytosol plasma membrane focal adhesion cell cortex Golgi organization small GTPase mediated signal transduction nervous system development protein kinase binding lamellipodium lamellipodium assembly cell junction growth cone positive regulation of protein binding macromolecular complex regulation of Rho protein signal transduction intracellular signal transduction cell projection neuron projection neuronal cell body positive regulation of apoptotic process positive regulation of GTPase activity astrocyte cell migration positive regulation of growth hormone secretion postsynaptic actin cytoskeleton organization GABA-ergic synapse regulation of GTP binding Rac GTPase binding uc009kvv.1 uc009kvv.2 uc009kvv.3 uc009kvv.4 
ENSMUST00000110918.3 Cdin1 ENSMUST00000110918.3 CDAN1 interacting nuclease 1, transcript variant 2 (from RefSeq NM_207264.5) CDIN1_MOUSE Cdin1 ENSMUST00000110918.1 ENSMUST00000110918.2 NM_207264 Q3U4G0 Q80WT3 Q8C1X6 uc008lqr.1 uc008lqr.2 uc008lqr.3 uc008lqr.4 Plays a role in erythroid cell differentiation. Nucleus Cytoplasm Note=Mainly nuclear. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U4G0-1; Sequence=Displayed; Name=2; IsoId=Q3U4G0-2; Sequence=VSP_022272; Sequence=BAE32471.1; Type=Frameshift; Evidence=; molecular_function cellular_component nucleus cytoplasm biological_process erythrocyte differentiation uc008lqr.1 uc008lqr.2 uc008lqr.3 uc008lqr.4 
ENSMUST00000110929.9 Nxpe5 ENSMUST00000110929.9 neurexophilin and PC-esterase domain family, member 5 (from RefSeq NM_001013773.3) BC055004 E9PXC9 E9PXC9_MOUSE ENSMUST00000110929.1 ENSMUST00000110929.2 ENSMUST00000110929.3 ENSMUST00000110929.4 ENSMUST00000110929.5 ENSMUST00000110929.6 ENSMUST00000110929.7 ENSMUST00000110929.8 NM_001013773 Nxpe5 uc012efk.1 uc012efk.2 Belongs to the NXPE family. molecular_function cellular_component biological_process membrane integral component of membrane uc012efk.1 uc012efk.2 
ENSMUST00000110934.9 Cnpy4 ENSMUST00000110934.9 canopy FGF signaling regulator 4, transcript variant 2 (from RefSeq NM_178612.5) CNPY4_MOUSE ENSMUST00000110934.1 ENSMUST00000110934.2 ENSMUST00000110934.3 ENSMUST00000110934.4 ENSMUST00000110934.5 ENSMUST00000110934.6 ENSMUST00000110934.7 ENSMUST00000110934.8 NM_178612 Prat4b Q8BQ47 Q8BT84 Q8BTB1 Q8CCG0 uc009aez.1 uc009aez.2 uc009aez.3 Plays a role in the regulation of the cell surface expression of TLR4. Interacts with TLR4. Secreted Highly expressed in lung, spleen, thymus, and uterus. Moderately expressed in kidney, stomach and placenta. Weakly expressed in brain, heart, liver, small intestine, skeletal muscle and testis. Belongs to the canopy family. Sequence=BAC25336.1; Type=Frameshift; Evidence=; Sequence=BAC25383.1; Type=Frameshift; Evidence=; receptor binding cellular_component extracellular region regulation of protein localization positive regulation of protein localization to plasma membrane uc009aez.1 uc009aez.2 uc009aez.3 
ENSMUST00000110936.8 Taf6 ENSMUST00000110936.8 TATA-box binding protein associated factor 6, transcript variant 4 (from RefSeq NM_001356602.1) ENSMUST00000110936.1 ENSMUST00000110936.2 ENSMUST00000110936.3 ENSMUST00000110936.4 ENSMUST00000110936.5 ENSMUST00000110936.6 ENSMUST00000110936.7 NM_001356602 Q62311 TAF6_MOUSE Taf2e uc291bbc.1 uc291bbc.2 The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID- A, TFIID-B, and TFIID-C. TAF6 homodimer connects TFIID modules, forming a rigid core. Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP- associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 and TAF12/TAFII20. The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TBP- free TAFII-histone acetylase complex (TFTC-HAT) (By similarity). Interacts with TP53/p53 (By similarity). Nucleus. Belongs to the TAF6 family. SAGA complex DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor TFIID complex cytosol chromatin organization DNA-templated transcription, initiation regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter negative regulation of cell proliferation aryl hydrocarbon receptor binding macromolecular complex transcription factor TFTC complex positive regulation of apoptotic process negative regulation of cell cycle SLIK (SAGA-like) complex protein heterodimerization activity RNA polymerase II transcriptional preinitiation complex assembly positive regulation of transcription initiation from RNA polymerase II promoter MLL1 complex positive regulation of intrinsic apoptotic signaling pathway uc291bbc.1 uc291bbc.2 
ENSMUST00000110942.11 Mboat2 ENSMUST00000110942.11 membrane bound O-acyltransferase domain containing 2, transcript variant 1 (from RefSeq NM_026037.3) A9EDS7 ENSMUST00000110942.1 ENSMUST00000110942.10 ENSMUST00000110942.2 ENSMUST00000110942.3 ENSMUST00000110942.4 ENSMUST00000110942.5 ENSMUST00000110942.6 ENSMUST00000110942.7 ENSMUST00000110942.8 ENSMUST00000110942.9 Lpcat4 MBOA2_MOUSE Mboat2 NM_026037 Oact2 Q8BHH5 Q8BM56 Q8R192 Q8R3I2 Q9CZ73 uc007neu.1 uc007neu.2 uc007neu.3 uc007neu.4 Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18287005, PubMed:29196633). Catalyzes the acylation of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) and to a lesser extend lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) (PubMed:18287005, PubMed:29196633). Does not acylates lysophosphatidic acid (LPA) and lysophosphatidylserine (PubMed:18287005). Prefers oleoyl-CoA as the acyl donor (PubMed:18287005, PubMed:29196633). May be involved in chondrocyte differentiation (PubMed:29196633). Reaction=a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2- diacyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:12937, ChEBI:CHEBI:57287, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:58342; EC=2.3.1.23; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12938; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:32995, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64381, ChEBI:CHEBI:64612; EC=2.3.1.n7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32996; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3- phosphocholine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:37627, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:77287, ChEBI:CHEBI:77294; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37628; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3- phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn- glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37631, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:77288, ChEBI:CHEBI:77291; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37632; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3- phosphoethanolamine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero- 3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37523, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75036, ChEBI:CHEBI:75038; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37524; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3- phosphocholine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:37519, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:73858, ChEBI:CHEBI:75034; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37520; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + CoA; Xref=Rhea:RHEA:37499, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74971, ChEBI:CHEBI:74986; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37500; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphoethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero- 3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:36015, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:73004, ChEBI:CHEBI:73007; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36016; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:35991, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35992; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:37207, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:72998, ChEBI:CHEBI:74000; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37208; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphoethanolamine = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero- 3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37419, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:73004, ChEBI:CHEBI:73999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37420; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn- glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35995, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35996; Evidence=; Partially inhibited by thimerosal. Kinetic parameters: KM=5.3 uM for oleoyl-CoA (in the presence of LPC C16:0 as cosubstrate) ; KM=48.15 uM for oleoyl-CoA (in the presence of LPE C16:0 as cosubstrate) ; KM=7.9 uM for LPC C16:0 (in the presence of oleoyl-CoA as cosubstrate) ; KM=27.7 uM for LPE C16:0 (in the presence of oleoyl-CoA as cosubstrate) ; Vmax=24.24 nmol/min/mg enzyme with oleoyl-CoA and LPC C16:0 as substrates ; Vmax=26.3 nmol/min/mg enzyme with oleoyl-CoA and LPE C16:0 as substrates ; Lipid metabolism; phospholipid metabolism. Membrane ; Multi-pass membrane protein Endoplasmic reticulum Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R3I2-1; Sequence=Displayed; Name=2; IsoId=Q8R3I2-2; Sequence=VSP_022458; Name=3; IsoId=Q8R3I2-3; Sequence=VSP_022457, VSP_022459; Highly expressed in epididymis, brain, testis, and ovary. Increased during chondrogenic differentiation. Belongs to the membrane-bound acyltransferase family. Sequence=BAC27567.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component endoplasmic reticulum lipid metabolic process phospholipid metabolic process biological_process phospholipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups 1-acylglycerophosphocholine O-acyltransferase activity uc007neu.1 uc007neu.2 uc007neu.3 uc007neu.4 
ENSMUST00000110945.4 Spata17 ENSMUST00000110945.4 spermatogenesis associated 17, transcript variant 2 (from RefSeq NM_029067.1) ENSMUST00000110945.1 ENSMUST00000110945.2 ENSMUST00000110945.3 NM_029067 Q5FWA7 Q8BQE6 Q9D552 SPT17_MOUSE Srg11 uc007dzw.1 uc007dzw.2 uc007dzw.3 uc007dzw.4 Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D552-1; Sequence=Displayed; Name=2; IsoId=Q9D552-2; Sequence=VSP_021906, VSP_021907; Name=3; IsoId=Q9D552-3; Sequence=VSP_021908, VSP_021909; Strongly expressed in adult testis but weakly expressed in the spleen and thymus. Strongly expressed in round and elongating spermatids, and weakly or not expressed in spermatozoa. It is uncertain whether Met-1 or Met-17 is the initiator. molecular_function calmodulin binding cellular_component cytoplasm biological_process uc007dzw.1 uc007dzw.2 uc007dzw.3 uc007dzw.4 
ENSMUST00000110947.2 Arhgap11a ENSMUST00000110947.2 Arhgap11a (from geneSymbol) A2AL19 A2AL19_MOUSE AK137111 Arhgap11a ENSMUST00000110947.1 uc008lps.1 uc008lps.2 uc008lps.3 signal transduction uc008lps.1 uc008lps.2 uc008lps.3 
ENSMUST00000110951.8 Cops6 ENSMUST00000110951.8 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. (from UniProt D3Z0F5) AK146410 Cops6 D3Z0F5 D3Z0F5_MOUSE ENSMUST00000110951.1 ENSMUST00000110951.2 ENSMUST00000110951.3 ENSMUST00000110951.4 ENSMUST00000110951.5 ENSMUST00000110951.6 ENSMUST00000110951.7 uc009aer.1 uc009aer.2 uc009aer.3 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. Cytoplasm Nucleus Belongs to the peptidase M67A family. CSN6 subfamily. protein deneddylation COP9 signalosome uc009aer.1 uc009aer.2 uc009aer.3 
ENSMUST00000110961.9 Zscan21 ENSMUST00000110961.9 zinc finger and SCAN domain containing 21, transcript variant 1 (from RefSeq NM_011757.3) ENSMUST00000110961.1 ENSMUST00000110961.2 ENSMUST00000110961.3 ENSMUST00000110961.4 ENSMUST00000110961.5 ENSMUST00000110961.6 ENSMUST00000110961.7 ENSMUST00000110961.8 NM_011757 Q07231 Q921V2 ZSC21_MOUSE Zfp-38 Zfp38 Zipro1 Znf38 uc009aen.1 uc009aen.2 uc009aen.3 uc009aen.4 Strong transcriptional activator (PubMed:1284028). Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (PubMed:27492080). Nucleus Expressed predominantly in the spermatocytes and spermatids of adult testes. It is also present at lower levels in the ovary, brain, spleen, embryo and fetus. First detected between 2 and 3 weeks after birth, in parallel with the onset and progression of meiosis. It is expressed during oogenesis from the pachytene stage of meiotic prophase through to postmeiotic cells. Expression in testis starts from postnatal day 7 (PND7) and expression remains constant until PND28 (PubMed:27492080). Male germ-cell-specific conditional knockout results in complete male infertility and meiotic arrest in spermatocytes (PubMed:27492080). Spermatocytes show impaired chromosomal synapsis and DNA double-strand breaks (DSB) repair and a significantly reduced expression of DSB repair-associated genes (PubMed:27492080). Belongs to the krueppel C2H2-type zinc-finger protein family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development spermatogenesis cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding oogenesis uc009aen.1 uc009aen.2 uc009aen.3 uc009aen.4 
ENSMUST00000110967.4 Smok3c ENSMUST00000110967.4 sperm motility kinase 3C (from RefSeq NM_001310703.1) A0A087WSF2 A0A087WSF2_MOUSE ENSMUST00000110967.1 ENSMUST00000110967.2 ENSMUST00000110967.3 NM_001310703 Smok3c uc057bvu.1 uc057bvu.2 uc057bvu.3 May play a role in sperm motility, especially in the regulation of flagellar function. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily. protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation intracellular signal transduction uc057bvu.1 uc057bvu.2 uc057bvu.3 
ENSMUST00000110969.5 Nalf1 ENSMUST00000110969.5 NALCN channel auxiliary factor 1, transcript variant 1 (from RefSeq NM_173446.2) ENSMUST00000110969.1 ENSMUST00000110969.2 ENSMUST00000110969.3 ENSMUST00000110969.4 Fam155a NALF1_MOUSE NM_173446 Nalf1 Q149R3 Q8CCS2 uc009kuj.1 uc009kuj.2 uc009kuj.3 Auxillary component of the NALCN sodium channel complex, a channel that regulates the resting membrane potential and controls neuronal excitability. Component of the NALCN channel complex (PubMed:33273469). NALCN complex consists of NALCN and auxiliary subunits, UNC79, UNC80 and NACL1. These auxiliary subunits are essential for the NALCN channel function (By similarity). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CCS2-1; Sequence=Displayed; Name=2; IsoId=Q8CCS2-2; Sequence=VSP_034162, VSP_034163; Belongs to the NALF family. plasma membrane membrane integral component of membrane calcium ion import across plasma membrane stretch-activated, cation-selective, calcium channel activity uc009kuj.1 uc009kuj.2 uc009kuj.3 
ENSMUST00000110978.7 Pilrb1 ENSMUST00000110978.7 paired immunoglobin-like type 2 receptor beta 1 (from RefSeq NM_133209.2) ENSMUST00000110978.1 ENSMUST00000110978.2 ENSMUST00000110978.3 ENSMUST00000110978.4 ENSMUST00000110978.5 ENSMUST00000110978.6 Fdfact NM_133209 PILRB_MOUSE Pilrb Q2YFS2 uc009aec.1 uc009aec.2 uc009aec.3 Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. Seems to associate with DAP12 and is a receptor for CD99. May be involved in target cell recognition by natural killer cells and in activation of dendritic cells. Interacts with CD99. Probably associates with DAP12. Membrane ; Single-pass type I membrane protein Widely expressed with highest levels in spleen, liver and lung. Predominantly expressed by natural killer cells, macrophages, and granulocytes and dendritic cells (BM-DC). Sequence=CAC19332.1; Type=Erroneous initiation; Evidence=; myeloid dendritic cell activation protein binding plasma membrane membrane integral component of membrane MHC class I protein binding negative regulation of osteoclast differentiation uc009aec.1 uc009aec.2 uc009aec.3 
ENSMUST00000110982.8 Ccl25 ENSMUST00000110982.8 Ccl25 (from geneSymbol) AK131875 Ccl25 ENSMUST00000110982.1 ENSMUST00000110982.2 ENSMUST00000110982.3 ENSMUST00000110982.4 ENSMUST00000110982.5 ENSMUST00000110982.6 ENSMUST00000110982.7 Q3V2F3 Q3V2F3_MOUSE uc291xxt.1 uc291xxt.2 extracellular region immune response chemokine activity cell chemotaxis uc291xxt.1 uc291xxt.2 
ENSMUST00000110993.2 Tgfbr3l ENSMUST00000110993.2 transforming growth factor, beta receptor III-like (from RefSeq NM_001195258.1) D3YZZ2 ENSMUST00000110993.1 Gm14378 NM_001195258 TGR3L_MOUSE Tgfbr3l uc012fzc.1 uc012fzc.2 Expressed in gonadotrope cells, acts as an inhibin B coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility. Cell membrane ; Single-pass membrane protein Expressed in pituitary gland gonadotrope cells. Glycosylated. Females show no effects on puberty onset, estrous cyclicity and body weight. They have increased litter sizes relative to wild-type with normal litter frequency. Females ovulate more eggs in natural cycles with increased uterine implantation sites. They have increased numbers of antral follicles and corpora lutea (PubMed:34910520). Double knockout females for TGFBR3L and gonadotrope- specific TGFBR3 are infertile. They have increased serum follicle- stimulating hormone (FSH), pituitary protein content relative to controls. They have larger ovaries with increased numbers of antral follicles and corpora lutea (PubMed:34910520). molecular_function cellular_component biological_process uc012fzc.1 uc012fzc.2 
ENSMUST00000110998.9 Map2k7 ENSMUST00000110998.9 mitogen-activated protein kinase kinase 7, transcript variant 2 (from RefSeq NM_011944.3) ENSMUST00000110998.1 ENSMUST00000110998.2 ENSMUST00000110998.3 ENSMUST00000110998.4 ENSMUST00000110998.5 ENSMUST00000110998.6 ENSMUST00000110998.7 ENSMUST00000110998.8 MP2K7_MOUSE Map2k7 Mkk7 NM_011944 O35406 O35720 O35871 O35872 O54780 O70242 O70243 Q8BSP1 Q8CE90 Q9QWG6 Q9R1Z3 Q9R1Z4 Q9R1Z5 Q9R1Z6 uc009kti.1 uc009kti.2 uc009kti.3 uc009kti.4 Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence= Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK. Isoforms 3 and 4 have lower basal activity but a higher level of inducible activation, than isoforms 2, 6, 7 and 8. Interacts with RASSF7, the interaction promotes phosphorylation. Interacts with VRK2 (By similarity). Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1 (By similarity). Interacts with SH3RF1, MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Found in a complex with SH3RF1, RAC1, MAP3K11/MLK3, MAPK8IP1/JIP1 and MAPK8/JNK1 (PubMed:23963642). Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1, MAPK8IP1/JIP1, MAPK8/JNK1 and MAPK9/JNK2 (PubMed:27084103). Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=8; Name=1 ; IsoId=Q8CE90-1; Sequence=Displayed; Name=2 ynonyms=a , beta 1 ; IsoId=Q8CE90-2; Sequence=VSP_052266, VSP_052268, VSP_052269; Name=3 ; Synonyms=alpha 2 ; IsoId=Q8CE90-3; Sequence=VSP_052265, VSP_052270, VSP_052271; Name=4 ; Synonyms=alpha 1 ; IsoId=Q8CE90-4; Sequence=VSP_052265, VSP_052268, VSP_052269; Name=5 ; Synonyms=b ; IsoId=Q8CE90-5; Sequence=VSP_052264, VSP_052267, VSP_052268, VSP_052269; Name=6 ynonyms=b , gamma 1 ; IsoId=Q8CE90-6; Sequence=VSP_052268, VSP_052269; Name=7 ; Synonyms=gamma 2 ; IsoId=Q8CE90-7; Sequence=VSP_052270, VSP_052271; Name=8 ; Synonyms=beta 2 ; IsoId=Q8CE90-8; Sequence=VSP_052266, VSP_052270, VSP_052271; Expressed at high levels in brain, lung, liver, skeletal muscle, kidney, and testis and at lower levels in the heart and spleen. Expressed at high levels in the brain, spinal cord, eyes, muscle, lungs, vertebrae, and intestine and at lower levels in the heart and livers at 12.5 dpc. At later stages of embryogenesis (14.5 dpc, 16.5 dpc, and 18.5 dpc) high levels were found in the brain, retina, bone marrow, skin, intestine, lung epithelium and the epithelial layers lining the olfactory cavity and developing teeth and whiskers. The DVD domain (residues 393-413) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation. The D domain (residues 37-73) contains a conserved docking site and is required for the binding to MAPK substrates. Activated by phosphorylation on Ser-287 and Thr-291 by MAP kinase kinase kinases (MAP3Ks). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. nucleotide binding activation of MAPK activity magnesium ion binding positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein tyrosine kinase activity protein binding ATP binding nucleus cytoplasm cytosol protein phosphorylation apoptotic process response to osmotic stress JNK cascade activation of JUN kinase activity protein C-terminus binding JUN kinase kinase activity response to heat response to UV response to wounding kinase activity phosphorylation transferase activity SAP kinase activity peptidyl-tyrosine phosphorylation enzyme binding protein kinase binding protein phosphatase binding signal transduction by protein phosphorylation mitogen-activated protein kinase kinase kinase binding activation of protein kinase activity positive regulation of telomere maintenance via telomerase response to tumor necrosis factor positive regulation of neuron apoptotic process positive regulation of transcription, DNA-templated positive regulation of JNK cascade metal ion binding stress-activated MAPK cascade positive regulation of telomerase activity positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to interleukin-1 positive regulation of telomere capping regulation of motor neuron apoptotic process uc009kti.1 uc009kti.2 uc009kti.3 uc009kti.4 
ENSMUST00000111016.9 Muc15 ENSMUST00000111016.9 mucin 15, transcript variant 1 (from RefSeq NM_172979.3) ENSMUST00000111016.1 ENSMUST00000111016.2 ENSMUST00000111016.3 ENSMUST00000111016.4 ENSMUST00000111016.5 ENSMUST00000111016.6 ENSMUST00000111016.7 ENSMUST00000111016.8 MUC15_MOUSE NM_172979 Q3UQC4 Q6XYQ9 Q7TMH6 Q8C6Z1 Q8CE82 uc008lmz.1 uc008lmz.2 uc008lmz.3 uc008lmz.4 Membrane ; Single-pass type I membrane protein Highly glycosylated (N- and O-linked carbohydrates). Sequence=AAO45176.1; Type=Frameshift; Evidence=; Sequence=AAO45177.1; Type=Frameshift; Evidence=; molecular_function biological_process membrane integral component of membrane uc008lmz.1 uc008lmz.2 uc008lmz.3 uc008lmz.4 
ENSMUST00000111026.3 Slc5a12 ENSMUST00000111026.3 solute carrier family 5 (sodium/glucose cotransporter), member 12, transcript variant 2 (from RefSeq NM_001177624.1) ENSMUST00000111026.1 ENSMUST00000111026.2 NM_001177624 Q0D2G1 Q49B93 Q6A4K8 SC5AC_MOUSE Smct2 uc008lmx.1 uc008lmx.2 uc008lmx.3 uc008lmx.4 Acts as an electroneutral and low-affinity sodium (Na(+))- dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate. Reaction=(S)-lactate(out) + Na(+)(out) = (S)-lactate(in) + Na(+)(in); Xref=Rhea:RHEA:75791, ChEBI:CHEBI:16651, ChEBI:CHEBI:29101; Evidence=; Reaction=Na(+)(out) + nicotinate(out) = Na(+)(in) + nicotinate(in); Xref=Rhea:RHEA:75795, ChEBI:CHEBI:29101, ChEBI:CHEBI:32544; Evidence=; Reaction=Na(+)(out) + pyruvate(out) = Na(+)(in) + pyruvate(in); Xref=Rhea:RHEA:75799, ChEBI:CHEBI:15361, ChEBI:CHEBI:29101; Evidence=; Reaction=Na(+)(out) + propanoate(out) = Na(+)(in) + propanoate(in); Xref=Rhea:RHEA:75807, ChEBI:CHEBI:17272, ChEBI:CHEBI:29101; Evidence=; Reaction=butanoate(out) + Na(+)(out) = butanoate(in) + Na(+)(in); Xref=Rhea:RHEA:75803, ChEBI:CHEBI:17968, ChEBI:CHEBI:29101; Evidence=; Reaction=acetoacetate(out) + Na(+)(out) = acetoacetate(in) + Na(+)(in); Xref=Rhea:RHEA:75811, ChEBI:CHEBI:13705, ChEBI:CHEBI:29101; Evidence=; Kinetic parameters: KM=35 mM for lactate ; Apical cell membrane ; Multi-pass membrane protein te=Detected at the brush border membrane of the kidney. Colocalizes with vimentin in Mueller cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q49B93-1; Sequence=Displayed; Name=2; IsoId=Q49B93-2; Sequence=VSP_033996; Expressed in the cortical region of the kidney corresponding to the proximal tubule. Expressed in Mueller cells of the inner retina (at protein level). Isoform 1 is expressed in the retina, kidney, small intestine and skeletal muscle. Isoform 2 is not detected in the kidney, small intestine and skeletal muscle. In the kidney, expressed predominantly in tubular epithelial cells of the cortical region and in the convoluted portions of the proximal tubule (pars convoluta). In the small intestine, its expression is highest in the proximal part and gradually decreased towards the distal end. Expressed in the neural retina. Not detected in the caecum and colon. Up-regulated by CEBPD. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. plasma membrane ion transport sodium ion transport lactate transmembrane transporter activity symporter activity membrane integral component of membrane apical plasma membrane transmembrane transporter activity lactate transmembrane transport transmembrane transport uc008lmx.1 uc008lmx.2 uc008lmx.3 uc008lmx.4 
ENSMUST00000111038.8 Epo ENSMUST00000111038.8 Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (from UniProt Q0VED9) BC119265 ENSMUST00000111038.1 ENSMUST00000111038.2 ENSMUST00000111038.3 ENSMUST00000111038.4 ENSMUST00000111038.5 ENSMUST00000111038.6 ENSMUST00000111038.7 Epo Q0VED9 Q0VED9_MOUSE uc009acn.1 uc009acn.2 uc009acn.3 Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Secreted Belongs to the EPO/TPO family. negative regulation of transcription from RNA polymerase II promoter response to hypoxia cytokine activity erythropoietin receptor binding hormone activity extracellular region extracellular space acute-phase response aging response to nutrient cell proliferation positive regulation of cell proliferation response to salt stress cell surface negative regulation of calcium ion transport into cytosol positive regulation of neuron projection development erythrocyte differentiation response to lipopolysaccharide response to vitamin A response to testosterone erythropoietin-mediated signaling pathway positive regulation of activated T cell proliferation positive regulation of tyrosine phosphorylation of STAT protein erythrocyte maturation response to estrogen cell body positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of Ras protein signal transduction response to axon injury response to electrical stimulus response to hyperoxia positive regulation of ERK1 and ERK2 cascade response to interleukin-1 cellular hyperosmotic response response to dexamethasone negative regulation of neuron death negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress negative regulation of erythrocyte apoptotic process negative regulation of cation channel activity uc009acn.1 uc009acn.2 uc009acn.3 
ENSMUST00000111051.10 Bdnf ENSMUST00000111051.10 brain derived neurotrophic factor, transcript variant 2 (from RefSeq NM_001048139.1) Bdnf ENSMUST00000111051.1 ENSMUST00000111051.2 ENSMUST00000111051.3 ENSMUST00000111051.4 ENSMUST00000111051.5 ENSMUST00000111051.6 ENSMUST00000111051.7 ENSMUST00000111051.8 ENSMUST00000111051.9 NM_001048139 Q541P3 Q541P3_MOUSE uc008lme.1 uc008lme.2 uc008lme.3 The protein encoded by this gene is a member of the nerve growth factor family. It is involved in the growth, differentiation and survival of specific types of developing neurons both in the central nervous system (CNS) and the peripheral nervous system. It is also involved in regulating synaptic plasticity in the CNS. Expression of a similar gene in human is reduced in both Alzheimer's and Huntington disease patients. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. Monomers and homodimers. Binds to NTRK2/TRKB. Secreted Belongs to the NGF-beta family. receptor binding extracellular region signal transduction growth factor activity uc008lme.1 uc008lme.2 uc008lme.3 
ENSMUST00000111055.9 Ephb4 ENSMUST00000111055.9 Eph receptor B4, transcript variant 1 (from RefSeq NM_001159571.1) ENSMUST00000111055.1 ENSMUST00000111055.2 ENSMUST00000111055.3 ENSMUST00000111055.4 ENSMUST00000111055.5 ENSMUST00000111055.6 ENSMUST00000111055.7 ENSMUST00000111055.8 Ephb4 NM_001159571 Q8C8K1 Q8C8K1_MOUSE uc009ach.1 uc009ach.2 uc009ach.3 uc009ach.4 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein nucleotide binding cell migration involved in sprouting angiogenesis protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity ATP binding integral component of plasma membrane protein phosphorylation cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation protein autophosphorylation ephrin receptor signaling pathway uc009ach.1 uc009ach.2 uc009ach.3 uc009ach.4 
ENSMUST00000111063.8 Mpped2 ENSMUST00000111063.8 metallophosphoesterase domain containing 2, transcript variant 4 (from RefSeq NM_001356555.1) ENSMUST00000111063.1 ENSMUST00000111063.2 ENSMUST00000111063.3 ENSMUST00000111063.4 ENSMUST00000111063.5 ENSMUST00000111063.6 ENSMUST00000111063.7 MPPD2_MOUSE NM_001356555 Q9CZJ0 uc008llm.1 uc008llm.2 uc008llm.3 uc008llm.4 Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system. Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Inhibited by nmolar levels of AMP and GMP. Homodimer. Belongs to the UPF0046 family. nucleotide binding cellular_component phosphoric diester hydrolase activity biological_process AMP binding hydrolase activity GMP binding manganese ion binding metal ion binding uc008llm.1 uc008llm.2 uc008llm.3 uc008llm.4 
ENSMUST00000111064.3 Ntsr2 ENSMUST00000111064.3 neurotensin receptor 2, transcript variant 7 (from RefSeq NR_182024.1) ENSMUST00000111064.1 ENSMUST00000111064.2 NR_182024 NTR2_MOUSE P70310 Q8VIF5 uc007nbw.1 uc007nbw.2 uc007nbw.3 Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. Cell membrane; Multi-pass membrane protein. Expressed maximally in the cerebellum, hippocampus, piriform cortex and neocortex of adult brain. Expressed poorly in 7-day-old brain. Expression increases at day 15 to reach a maximal level in 35-day-old brain. Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily. Sequence=AAB17285.1; Type=Frameshift; Evidence=; G-protein coupled receptor activity trans-Golgi network plasma membrane signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway neuropeptide signaling pathway cell surface membrane integral component of membrane G-protein coupled neurotensin receptor activity regulation of membrane potential protein homodimerization activity dendritic shaft perikaryon positive regulation of MAPK cascade protein heterodimerization activity positive regulation of ERK1 and ERK2 cascade uc007nbw.1 uc007nbw.2 uc007nbw.3 
ENSMUST00000111067.10 Lpin1 ENSMUST00000111067.10 lipin 1, transcript variant 4 (from RefSeq NM_001355598.1) A0A0R4J0V3 E9QKQ5 E9QKQ5_MOUSE ENSMUST00000111067.1 ENSMUST00000111067.2 ENSMUST00000111067.3 ENSMUST00000111067.4 ENSMUST00000111067.5 ENSMUST00000111067.6 ENSMUST00000111067.7 ENSMUST00000111067.8 ENSMUST00000111067.9 Lpin1 NM_001355598 uc288fbi.1 uc288fbi.2 Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn- glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27430; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the lipin family. regulation of transcription from RNA polymerase II promoter phosphatidate phosphatase activity fatty acid catabolic process dephosphorylation triglyceride biosynthetic process animal organ regeneration cellular response to insulin stimulus uc288fbi.1 uc288fbi.2 
ENSMUST00000111072.8 Adam28 ENSMUST00000111072.8 a disintegrin and metallopeptidase domain 28, transcript variant 5 (from RefSeq NR_102399.1) ADA28_MOUSE ENSMUST00000111072.1 ENSMUST00000111072.2 ENSMUST00000111072.3 ENSMUST00000111072.4 ENSMUST00000111072.5 ENSMUST00000111072.6 ENSMUST00000111072.7 NR_102399 Q5D070 Q8K5D2 Q8K5D3 Q9JLN6 uc007ult.1 uc007ult.2 uc007ult.3 uc007ult.4 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are typically membrane-anchored, although a form of this protein may be secreted. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a mature protein product. This protein may bind to integrins and regulate lymphocyte migration by enhancing cell adhesion. [provided by RefSeq, Aug 2015]. May play a role in organogenesis and organ-specific functions such as thymic T-cell development. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9JLN6-1; Sequence=Displayed; Name=2; IsoId=Q9JLN6-2; Sequence=VSP_005488; Name=3; IsoId=Q9JLN6-3; Sequence=VSP_005489, VSP_005490; Strong expression in thymic epithelial cells and developmentally related tissues including the trachea, thyroid, lung and stomach, but not in lymphocytes. Expressed at high levels also in epididymis. In contrast with human is not expressed in immature or mature lymphocyte populations of thymocytes, lymph node, spleen, and bone marrow. The expression patterns in adult and day 15.5 embryos are similar. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. Pro-domain removal and maturation may be, at least in part, autocatalytic. metalloendopeptidase activity mitochondrion plasma membrane proteolysis peptidase activity metallopeptidase activity membrane integral component of membrane hydrolase activity metal ion binding uc007ult.1 uc007ult.2 uc007ult.3 uc007ult.4 
ENSMUST00000111080.8 Ap1s1 ENSMUST00000111080.8 adaptor protein complex AP-1, sigma 1, transcript variant 1 (from RefSeq NM_007457.4) AP1S1_MOUSE Ap19 ENSMUST00000111080.1 ENSMUST00000111080.2 ENSMUST00000111080.3 ENSMUST00000111080.4 ENSMUST00000111080.5 ENSMUST00000111080.6 ENSMUST00000111080.7 NM_007457 P61967 P82267 Q00382 Q9BTN4 Q9UDW9 uc009abm.1 uc009abm.2 uc009abm.3 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin- coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Detected in brain and embryonic stem cells. Belongs to the adaptor complexes small subunit family. protein binding Golgi apparatus trans-Golgi network cytosol clathrin-coated pit intracellular protein transport response to virus protein transport membrane vesicle-mediated transport membrane coat AP-1 adaptor complex cytoplasmic vesicle membrane cytoplasmic vesicle retrograde transport, endosome to Golgi terminal bouton intracellular membrane-bounded organelle uc009abm.1 uc009abm.2 uc009abm.3 
ENSMUST00000111087.10 Pax6 ENSMUST00000111087.10 paired box 6, transcript variant 8 (from RefSeq NM_001310146.1) ENSMUST00000111087.1 ENSMUST00000111087.2 ENSMUST00000111087.3 ENSMUST00000111087.4 ENSMUST00000111087.5 ENSMUST00000111087.6 ENSMUST00000111087.7 ENSMUST00000111087.8 ENSMUST00000111087.9 NM_001310146 P32117 P63015 P70601 PAX6_MOUSE Pax-6 Q3UTV5 Q62222 Q64037 Q8CEI5 Q8VDB5 Q921Q8 Sey uc008lkv.1 uc008lkv.2 uc008lkv.3 uc008lkv.4 uc008lkv.5 This gene encodes a homeobox-containing protein that functions as a regulator of transcription. It plays a key role in the development of neural tissues, particularly the eye. Activity of this protein is also required for expression of glucagon in the pancreas. This gene is regulated by multiple enhancers located up to tens or hundreds of kilobases upstream and downstream of the transcription start sites. Mutations in this gene or deletion of these regulatory elements results in severe defects in eye development. Alternative splicing and the use of alternative promoters results in multiple transcript variants, some of which encode proteins that lack the N-terminal paired domain. [provided by RefSeq, Jul 2015]. Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (PubMed:9163426). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (PubMed:23990468). Interacts with MAF and MAFB (PubMed:17901057). Interacts with TRIM11; this interaction leads to ubiquitination and proteasomal degradation, as well as inhibition of transactivation, possibly in part by preventing PAX6 binding to consensus DNA sequences (PubMed:18628401). Interacts with TLE6/GRG6 (PubMed:23990468). P63015; O35845: Smarca4; NbExp=2; IntAct=EBI-1395428, EBI-371515; P63015; P63166: Sumo1; NbExp=2; IntAct=EBI-1395428, EBI-80152; Nucleus [Isoform 1]: Nucleus [Isoform 3]: Nucleus Cytoplasm [Isoform 5a]: Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P63015-1; Sequence=Displayed; Name=5a; Synonyms=Pax6-5a; IsoId=P63015-2; Sequence=VSP_011530; Name=3; Synonyms=p32; IsoId=P63015-3; Sequence=VSP_054294; Expressed in osteoclasts. [Isoform 1]: Dominant isoform expressed in the eye, including in the retina and cornea (PubMed:21084637). Abundantly expressed in the lens epithelium (PubMed:21084637). [Isoform 3]: Dominant isoform expressed in the eye, including in the retina and cornea (PubMed:21084637). Weakly expressed in the lens epithelium (PubMed:21084637). Expressed in the developing eye, nose, brain and pancreas (PubMed:21084637). At 9 dpc, expressed in the telencephalon, diencephalon, neural tube, optic vesicle and pancreas. Throughout development, expression continues in the dorsal and ventral pancreas. Expressed during cortical neurogenesis from 11 to 18 dpc. High levels in the early radial glial progenitors from 11 to 14 dpc and gradually decrease thereafter (at protein level). During corticogenesis, the protein level declines faster than that of the mRNA, due to proteasomal degradation (PubMed:18628401). [Isoform 1]: Abundantly expressed in the newborn eye. [Isoform 3]: Expressed in the developing eye at 9.5 dpc, the expression becomes much stronger and additionally expressed in the neural tube and optic and lens vesicles at 11.5 dpc. Expression is then reduced by 12.5 dpc and becomes significantly decreased from 14.5 dpc to 18.5 dpc of embryonic development. [Isoform 5a]: Significantly expressed in the newborn eye. Induced by TNFSF11/RANKL-induced osteoclastogenesis. Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. [Isoform 3]: Sumoylated by SUMO1 at 'Lys-91'. Note=Defects in Pax6 are the cause of a condition known as small eye (Sey) which results in the complete lack of eyes and nasal primordia. Belongs to the paired homeobox family. Sequence=AAA40109.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter establishment of mitotic spindle orientation nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding blood vessel development cell fate determination neural crest cell migration neuron migration negative regulation of protein phosphorylation positive regulation of neuroblast proliferation epithelial cell development lens development in camera-type eye regionalization type B pancreatic cell differentiation pancreatic A cell differentiation pancreatic A cell development DNA binding AT DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter smoothened signaling pathway multicellular organism development axonogenesis axon guidance brain development salivary gland morphogenesis transcription factor binding negative regulation of cell proliferation response to wounding regulation of asymmetric cell division dorsal/ventral axis specification anterior/posterior pattern specification dorsal/ventral pattern formation regulation of gene expression positive regulation of gene expression positive regulation of cell death regulation of neuron projection development protein kinase binding pallium development rhombomere morphogenesis olfactory bulb development oligodendrocyte cell fate specification cerebral cortex regionalization forebrain dorsal/ventral pattern formation commitment of neuronal cell to specific neuron type in forebrain forebrain-midbrain boundary formation regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment telencephalon regionalization pituitary gland development habenula development interkinetic nuclear migration signal transduction involved in regulation of gene expression cell differentiation keratinocyte differentiation regulation of cell migration positive regulation of epithelial cell differentiation forebrain development hindbrain development ubiquitin protein ligase binding lacrimal gland development protein localization to organelle histone acetyltransferase binding eye photoreceptor cell development glucose homeostasis positive regulation of cell fate specification camera-type eye development sequence-specific DNA binding transcription regulatory region DNA binding cell fate commitment regulation of neuron differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of timing of cell differentiation embryonic camera-type eye morphogenesis astrocyte differentiation negative regulation of epithelial cell proliferation regulation of neurogenesis retina development in camera-type eye olfactory bulb mitral cell layer development iris morphogenesis cornea development in camera-type eye neural precursor cell proliferation positive regulation of glucagon secretion co-SMAD binding R-SMAD binding HMG box domain binding learned vocalization behavior or vocal learning insulin metabolic process positive regulation of core promoter binding sensory neuron migration cellular response to leukemia inhibitory factor negative regulation of neural precursor cell proliferation positive regulation of neuron migration uc008lkv.1 uc008lkv.2 uc008lkv.3 uc008lkv.4 uc008lkv.5 
ENSMUST00000111093.8 Cldn15 ENSMUST00000111093.8 Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake. (from UniProt Q9Z0S5) AK008683 CLD15_MOUSE ENSMUST00000111093.1 ENSMUST00000111093.2 ENSMUST00000111093.3 ENSMUST00000111093.4 ENSMUST00000111093.5 ENSMUST00000111093.6 ENSMUST00000111093.7 Q9D7Z0 Q9D8A6 Q9Z0S5 uc009abg.1 uc009abg.2 uc009abg.3 uc009abg.4 Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake. Can form linear homooligomers in the membrane, giving rise to tight junction strand-like structures. Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand- like structures in electron microscopy. Detected in duodenum, jejunum and ileum. Detected on intestinal villi and crypts (at protein level). Ubiquitous. Detected in small intestine, colon, jejunum, heart, kidney and lung. Palmitoylated when heterogeneously expressed in S.frugiperda cells. No visible phenotype at birth and during the first four weeks after birth. After about eight weeks, the upper part of the small intestine is abnormally increased both in length and in thickness with enlarged villi and crypts. The villi are about two times larger than normal, and each is associated with about forty abnormally large crypts instead of the normally observed ratio of ten crypts per villus. In contrast, there is no difference in the size of the lower part of the small intestine. The body weight of mutant mice does not differ from that of wild-type littermates (PubMed:18242218). According to PubMed:20727355, the intestinal mucosa from newborn and adult mutant mice displays strongly decreased transepithelial conductance with strongly reduced paracellular Na(+) permeability, but no major changes in paracellular permeability to Cl(-). Adults show strongly decreased Na(+) levels in the lumen of the small intestine. Mutant mice also display decreased intestinal glucose uptake, probably due to decreased Na(+) levels. According to PubMed:23089202, mutant mice lacking both Cldn2 and Cldn15 display no visible phenotype at birth, but show decreased growth after about 10 days, severe developmental retardation about 14 days after birth, and then die from malnutrition. None survive more than 25 days after birth. Mice lacking both Cldn2 and Cldn15 show abnormally low Na(+) levels in the intestine, leading to decreased intestinal glucose uptake; glucose uptake can be restored to normal levels by addition of Na(+). Likewise, mice lacking both Cldn2 and Cldn15 show decreased intestinal uptake of milk fat, fatty acids, bile acids and amino acids; again, normal bile acid and amino acid uptake can be restored by the addition of Na(+). Belongs to the claudin family. structural molecule activity plasma membrane bicellular tight junction ion transport membrane integral component of membrane lateral plasma membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding uc009abg.1 uc009abg.2 uc009abg.3 uc009abg.4 
ENSMUST00000111095.4 Gnrh1 ENSMUST00000111095.4 gonadotropin releasing hormone 1, transcript variant 1 (from RefSeq NM_008145.4) ENSMUST00000111095.1 ENSMUST00000111095.2 ENSMUST00000111095.3 Gnrh1 NM_008145 Q3UTE9 Q3UTE9_MOUSE uc007ulh.1 uc007ulh.2 uc007ulh.3 uc007ulh.4 uc007ulh.5 This gene encodes hypophysiotropic peptides belonging to the family of gonadotropin-releasing hormones that stimulate the release of gonadotropins and suppress secretion of prolactin from the pituitary gland. The encoded protein is proteolytically processed to generate two biologically active mature peptides. A deletional mutation encompassing the distal half of this gene in mice resulting in the loss of the encoded protein leads to hypogonadism and infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]. Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Secreted Belongs to the GnRH family. hormone activity gonadotropin hormone-releasing hormone activity extracellular region extracellular space mitochondrion Golgi-associated vesicle signal transduction multicellular organism development female pregnancy aging response to organic cyclic compound male sex determination dendrite response to corticosteroid response to lipopolysaccharide negative regulation of immature T cell proliferation response to testosterone response to prostaglandin E response to potassium ion ovulation cycle neuron projection negative regulation of apoptotic process perikaryon response to peptide hormone axon terminus estrous cycle cytoplasmic side of rough endoplasmic reticulum membrane neurosecretory vesicle response to prolactin uc007ulh.1 uc007ulh.2 uc007ulh.3 uc007ulh.4 uc007ulh.5 
ENSMUST00000111108.10 Psen2 ENSMUST00000111108.10 presenilin 2, transcript variant 6 (from RefSeq NR_185180.1) ENSMUST00000111108.1 ENSMUST00000111108.2 ENSMUST00000111108.3 ENSMUST00000111108.4 ENSMUST00000111108.5 ENSMUST00000111108.6 ENSMUST00000111108.7 ENSMUST00000111108.8 ENSMUST00000111108.9 NR_185180 Psen2 Q3U4P5 Q3U4P5_MOUSE uc007dwd.1 uc007dwd.2 uc007dwd.3 Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Homodimer. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein The PAL motif is required for normal active site conformation. Belongs to the peptidase A22A family. Golgi membrane kinetochore response to hypoxia aspartic-type endopeptidase activity nuclear inner membrane early endosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus centrosome plasma membrane integral component of plasma membrane proteolysis membrane protein ectodomain proteolysis Notch signaling pathway synaptic vesicle peptidase activity membrane integral component of membrane protein processing hydrolase activity macromolecular complex intracellular signal transduction aspartic endopeptidase activity, intramembrane cleaving amyloid precursor protein catabolic process positive regulation of catalytic activity synaptic membrane integral component of presynaptic membrane mitochondrion-ER tethering uc007dwd.1 uc007dwd.2 uc007dwd.3 
ENSMUST00000111113.3 Wdr35 ENSMUST00000111113.3 WD repeat domain 35, transcript variant 2 (from RefSeq NM_001159527.1) E9QLW3 ENSMUST00000111113.1 ENSMUST00000111113.2 NM_001159527 Q8BND3 Q8CDL4 WDR35_MOUSE Wdr35 uc007nak.1 uc007nak.2 uc007nak.3 uc007nak.4 As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (PubMed:21473986). May promote CASP3 activation and TNF-stimulated apoptosis (By similarity). Component of the IFT complex A (IFT-A) complex. IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B. Interacts directy with IFT122, ITF43 and TTC21B. Interacts with IFT43. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, cilium basal body Note=Immunofluorescence studies in IMCD3 cells show that Wdr35 accumulates at and around centrosomes and basal bodies of serum-starved cells, with fainter punctate staining along the cilia axoneme. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BND3-1; Sequence=Displayed; Name=2; IsoId=Q8BND3-2; Sequence=VSP_009733; cytoplasm centrosome microtubule organizing center cytoskeleton cilium axoneme response to toxic substance negative regulation of gene expression cell projection organization intraciliary transport particle A response to lipopolysaccharide intraciliary retrograde transport ciliary basal body intraciliary transport cell projection positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of nitric oxide biosynthetic process cilium assembly protein localization to cilium cellular response to glucose stimulus cellular response to tumor necrosis factor positive regulation of release of cytochrome c from mitochondria liver regeneration response to paclitaxel cellular response to paclitaxel cellular response to leukemia inhibitory factor uc007nak.1 uc007nak.2 uc007nak.3 uc007nak.4 
ENSMUST00000111114.8 Ccdc73 ENSMUST00000111114.8 coiled-coil domain containing 73 (from RefSeq NM_177600.4) A2A6Z9 CCD73_MOUSE ENSMUST00000111114.1 ENSMUST00000111114.2 ENSMUST00000111114.3 ENSMUST00000111114.4 ENSMUST00000111114.5 ENSMUST00000111114.6 ENSMUST00000111114.7 NM_177600 Q501M4 Q8CDM4 uc008lkk.1 uc008lkk.2 uc008lkk.3 Sequence=BAC26648.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc008lkk.1 uc008lkk.2 uc008lkk.3 
ENSMUST00000111118.8 Tcp11l1 ENSMUST00000111118.8 Belongs to the TCP11 family. (from UniProt Q8BTG3) AK082024 ENSMUST00000111118.1 ENSMUST00000111118.2 ENSMUST00000111118.3 ENSMUST00000111118.4 ENSMUST00000111118.5 ENSMUST00000111118.6 ENSMUST00000111118.7 Q8BTG3 T11L1_MOUSE uc289yyr.1 uc289yyr.2 Belongs to the TCP11 family. molecular_function microtubule biological_process uc289yyr.1 uc289yyr.2 
ENSMUST00000111122.9 Pum2 ENSMUST00000111122.9 pumilio RNA-binding family member 2, transcript variant 3 (from RefSeq NM_001160220.1) ENSMUST00000111122.1 ENSMUST00000111122.2 ENSMUST00000111122.3 ENSMUST00000111122.4 ENSMUST00000111122.5 ENSMUST00000111122.6 ENSMUST00000111122.7 ENSMUST00000111122.8 NM_001160220 Pum2 Q3UR91 Q3UR91_MOUSE uc007mzx.1 uc007mzx.2 uc007mzx.3 uc007mzx.4 Cytoplasmic granule RNA binding uc007mzx.1 uc007mzx.2 uc007mzx.3 uc007mzx.4 
ENSMUST00000111137.8 Upk3bl ENSMUST00000111137.8 Upk3bl (from geneSymbol) 2310043J07Rik BC115563 D3YZ16 D3YZ16_MOUSE ENSMUST00000111137.1 ENSMUST00000111137.2 ENSMUST00000111137.3 ENSMUST00000111137.4 ENSMUST00000111137.5 ENSMUST00000111137.6 ENSMUST00000111137.7 Upk3bl uc008zzr.1 uc008zzr.2 uc008zzr.3 uc008zzr.4 peroxidase activity response to oxidative stress membrane integral component of membrane heme binding oxidation-reduction process cellular oxidant detoxification uc008zzr.1 uc008zzr.2 uc008zzr.3 uc008zzr.4 
ENSMUST00000111145.10 Dtx2 ENSMUST00000111145.10 deltex 2, E3 ubiquitin ligase, transcript variant 4 (from RefSeq NM_001256098.1) DTX2_MOUSE ENSMUST00000111145.1 ENSMUST00000111145.2 ENSMUST00000111145.3 ENSMUST00000111145.4 ENSMUST00000111145.5 ENSMUST00000111145.6 ENSMUST00000111145.7 ENSMUST00000111145.8 ENSMUST00000111145.9 NM_001256098 Q8R3P2 Q9CZV3 Q9ER07 Q9ER08 uc008zzp.1 uc008zzp.2 uc008zzp.3 uc008zzp.4 Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1. Cytoplasm Nucleus Note=Predominantly cytoplasmic. Partially nuclear. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R3P2-1; Sequence=Displayed; Name=2; Synonyms=DeltaE; IsoId=Q8R3P2-2; Sequence=VSP_008351; Name=3; IsoId=Q8R3P2-3; Sequence=VSP_008352, VSP_008353; Expressed in testis and the CNS. In the CNS, it is expressed in the developing neural tube starting from 10.5 dpc in the spinal cord and around 11.5 dpc in the telencephalon. Expressed ubiquitously throughout the spinal cord and telencephalon during neurogenesis. Expressed throughout the developing retina at 15.5 dpc. Not expressed in the somite or presomite during somitogenesis. Expressed slightly earlier that Dtx1 and Dtx3. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. Note=Recurrent site of retroviral integration in murine B-cell lymphomas. [Isoform 3]: Splicing donor site not canonical. Belongs to the Deltex family. protein binding nucleus nucleoplasm cytoplasm Notch signaling pathway zinc ion binding protein ubiquitination transferase activity nuclear membrane metal ion binding uc008zzp.1 uc008zzp.2 uc008zzp.3 uc008zzp.4 
ENSMUST00000111153.8 Ssc4d ENSMUST00000111153.8 Secreted (from UniProt A1L0T3) A1L0T3 BC117747 ENSMUST00000111153.1 ENSMUST00000111153.2 ENSMUST00000111153.3 ENSMUST00000111153.4 ENSMUST00000111153.5 ENSMUST00000111153.6 ENSMUST00000111153.7 SRB4D_MOUSE Srcrb4d Ssc4d uc291aql.1 uc291aql.2 Secreted scavenger receptor activity extracellular region endocytosis biological_process external side of plasma membrane membrane uc291aql.1 uc291aql.2 
ENSMUST00000111154.4 Fam228a ENSMUST00000111154.4 family with sequence similarity 228, member A (from RefSeq NM_029107.3) ENSMUST00000111154.1 ENSMUST00000111154.2 ENSMUST00000111154.3 F228A_MOUSE NM_029107 Q8CDW1 Q9D5M5 uc007myb.1 uc007myb.2 uc007myb.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CDW1-1; Sequence=Displayed; Name=2; IsoId=Q8CDW1-2; Sequence=VSP_035162, VSP_035163; Belongs to the FAM228 family. molecular_function cellular_component biological_process uc007myb.1 uc007myb.2 uc007myb.3 
ENSMUST00000111159.2 Akt3 ENSMUST00000111159.2 AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down- regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis. (from UniProt Q9WUA6) AKT3_MOUSE BC066861 ENSMUST00000111159.1 Q9WUA6 uc287ofq.1 uc287ofq.2 AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down- regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Two specific sites, one in the kinase domain (Thr- 305) and the other in the C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation. IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation. Interacts with TRAF6 (By similarity). Interacts with KCTD20 (PubMed:24156551). Interacts with BTBD10 (PubMed:18160256). Nucleus Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PKB gamma; IsoId=Q9WUA6-1; Sequence=Displayed; Name=2; Synonyms=PKB gamma 1; IsoId=Q9WUA6-2; Sequence=VSP_004948; Isoform 1 is expressed in prostate, testis, uterus and mammary gland and isoform 2 is expressed in prostate, testis and mammary gland. Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane. Phosphorylation on Thr-305 and Ser-472 is required for full activity. Ubiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome (By similarity). O-GlcNAcylation at Thr-302 and Thr-309 inhibits activating phosphorylation at Thr-305 via disrupting the interaction between AKT and PDK1. Results in the cytoplasmic accumulation of the master regulator of mitochondrial biogenesis, Ppargc1a, and a reduction in known Ppargc1a target genes, which leads to an abnormal mitochondrial phenotype in the brain tissue. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. In light of strong homologies in the primary amino acid sequence, the 3 AKT kinases were long surmised to play redundant and overlapping roles. More recent studies has brought into question the redundancy within AKT kinase isoforms and instead pointed to isoform specific functions in different cellular events and diseases. AKT1 is more specifically involved in cellular survival pathways, by inhibiting apoptotic processes; whereas AKT2 is more specific for the insulin receptor signaling pathway. Moreover, while AKT1 and AKT2 are often implicated in many aspects of cellular transformation, the 2 isoforms act in a complementary opposing manner. The role of AKT3 is less clear, though it appears to be predominantly expressed in brain. mitochondrial genome maintenance nucleotide binding positive regulation of endothelial cell proliferation protein kinase activity protein serine/threonine kinase activity protein kinase C binding protein binding ATP binding nucleus cytoplasm plasma membrane protein phosphorylation signal transduction positive regulation of sodium ion transport membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation positive regulation of TOR signaling cellular response to insulin stimulus intracellular signal transduction positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis positive regulation of cell size brain morphogenesis homeostasis of number of cells within a tissue positive regulation of cell migration involved in sprouting angiogenesis positive regulation of vascular endothelial cell proliferation positive regulation of artery morphogenesis negative regulation of cellular senescence uc287ofq.1 uc287ofq.2 
ENSMUST00000111171.6 Pom121 ENSMUST00000111171.6 nuclear pore membrane protein 121 (from RefSeq NM_148932.2) ENSMUST00000111171.1 ENSMUST00000111171.2 ENSMUST00000111171.3 ENSMUST00000111171.4 ENSMUST00000111171.5 NM_148932 Nup121 PO121_MOUSE Q7TSH5 Q8K3Z9 uc008zyi.1 uc008zyi.2 uc008zyi.3 Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL) (By similarity). Nucleus, nuclear pore complex Nucleus membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single- pass membrane protein Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase. Contains F-X-F-G repeats. Proteolytically cleaved by caspase-3 during apoptosis. Belongs to the POM121 family. nucleus nuclear pore nucleoplasm endoplasmic reticulum endoplasmic reticulum membrane protein import into nucleus nuclear pore organization nuclear localization sequence binding protein transport membrane integral component of membrane structural constituent of nuclear pore nuclear membrane mRNA transport uc008zyi.1 uc008zyi.2 uc008zyi.3 
ENSMUST00000111178.2 Efr3b ENSMUST00000111178.2 EFR3 homolog B (from RefSeq NM_001082483.2) B2RXT1 EFR3B_MOUSE ENSMUST00000111178.1 Kiaa0953 NM_001082483 Q6ZQ18 uc007mxh.1 uc007mxh.2 Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3B probably acts as the membrane-anchoring component. Also involved in responsiveness to G- protein-coupled receptors; it is however unclear whether this role is direct or indirect. Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2). Cell membrane ; Lipid-anchor Cytoplasm, cytosol Note=Palmitoylation anchors the protein to the plasma membrane. A small amount is observed in the cytosol. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZQ18-1; Sequence=Displayed; Name=2; IsoId=Q6ZQ18-2; Sequence=VSP_029808; Widely expressed. Palmitoylated at its N-terminus, anchoring the protein to the plasma membrane. Belongs to the EFR3 family. molecular_function cytoplasm cytosol plasma membrane membrane phosphatidylinositol phosphorylation protein localization to plasma membrane uc007mxh.1 uc007mxh.2 
ENSMUST00000111207.8 Defb30 ENSMUST00000111207.8 defensin beta 30, transcript variant 1 (from RefSeq NM_001039566.3) DFB30_MOUSE ENSMUST00000111207.1 ENSMUST00000111207.2 ENSMUST00000111207.3 ENSMUST00000111207.4 ENSMUST00000111207.5 ENSMUST00000111207.6 ENSMUST00000111207.7 NM_001039566 Q30KN4 uc007uhd.1 uc007uhd.2 uc007uhd.3 uc007uhd.4 Has antibacterial activity. Secreted Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium innate immune response uc007uhd.1 uc007uhd.2 uc007uhd.3 uc007uhd.4 
ENSMUST00000111214.4 Ifi204 ENSMUST00000111214.4 interferon activated gene 204 (from RefSeq NM_008329.2) B7ZNS3 ENSMUST00000111214.1 ENSMUST00000111214.2 ENSMUST00000111214.3 IFI4_MOUSE NM_008329 P0DOV2 P15092 Q08619 Q3TM07 Q3U776 Q3U7F4 Q3U7K5 Q3UCH9 Q8C4X3 Q921V9 uc007drv.1 uc007drv.2 uc007drv.3 Interferon-stimulated protein that plays a role in several biological processes including cell differentiation, autophagy and innate immunity (PubMed:16244109, PubMed:25710914, PubMed:30936875). Cooperates with CGAS to sense dsDNA and activates the STING-dependent type I IFN pathway (PubMed:25710914, PubMed:33619523). Mechanistically, gets acteylated upon bacterial infection and then translocates from nucleus into cytoplasm to recruit STING for activation of TBK1- dependent IRF3 nuclear translocation and IFN-beta release (PubMed:28529930). Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1- dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation. Interacts with UBTF. Interacts with RUNX2. Interacts with ID1, ID2 and ID3. Interacts with STING (PubMed:28529930). Nucleus Nucleus, nucleolus. Cytoplasm Note=Nuclear in proliferating cells, translocates to cytosol during cell differentiation or bacterial infection. Present in osteoblasts (at protein level). By beta interferon. By macrophage differentiation factors. During myocyte differentiation. By different bacterial infections such as Staphylococcus aureus or Mycobacterium bovis. The 2 HIN-200 domains are able to interact with RUNX2. Acetylated upon bacterial infection, leading to translocation from nucleus to cytoplasm and subsequent recruitment of STING to activate IFN-beta production. Deletion mutant mice display increased susceptibility to Staphylococcus aureus pulmonary infection. Belongs to the HIN-200 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding activation of innate immune response double-stranded DNA binding transcription cofactor activity protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol regulation of transcription from RNA polymerase II promoter multicellular organism development transcription factor binding response to bacterium nuclear speck positive regulation of interleukin-1 beta production cellular response to interferon-alpha cellular response to interferon-beta nuclear inclusion body intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator identical protein binding positive regulation of osteoblast differentiation inner ear development uc007drv.1 uc007drv.2 uc007drv.3 
ENSMUST00000111220.8 Cadm3 ENSMUST00000111220.8 cell adhesion molecule 3, transcript variant 3 (from RefSeq NM_053199.4) CADM3_MOUSE ENSMUST00000111220.1 ENSMUST00000111220.2 ENSMUST00000111220.3 ENSMUST00000111220.4 ENSMUST00000111220.5 ENSMUST00000111220.6 ENSMUST00000111220.7 Igsf4b NM_053199 Necl1 Q8BSQ8 Q8K1H8 Q99N28 Syncam3 Tsll1 uc007dri.1 uc007dri.2 uc007dri.3 Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions. Homodimer. Can form trans-heterodimers with NECTIN3. Interacts with EPB41L1, DLG3, PALS2 and CASK. Cell membrane ingle-pass type I membrane protein Cell junction Mainly expressed in brain, in neuronal cell bodies of cerebellum, cortex, hippocampus, hypothalamus and spinal cord. In spinal cord predominantly expressed in motor neurons. Expressed in axons, presynaptic nerve terminals, glia cell processes. At 14.5 dpc predominantly expressed in the nervous system. The cytoplasmic region mediates interaction with EPB41L1, DLG3, PALS2 and CASK. Belongs to the nectin family. Sequence=AAH29659.1; Type=Erroneous initiation; Evidence=; protein binding plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules protein localization membrane integral component of membrane cell junction protein homodimerization activity integral component of presynaptic membrane uc007dri.1 uc007dri.2 uc007dri.3 
ENSMUST00000111224.5 Mptx2 ENSMUST00000111224.5 mucosal pentraxin 2 (from RefSeq NM_001205011.2) D3YYJ7 D3YYJ7_MOUSE ENSMUST00000111224.1 ENSMUST00000111224.2 ENSMUST00000111224.3 ENSMUST00000111224.4 Gm11062 Mptx2 NM_001205011 uc029qus.1 uc029qus.2 uc029qus.3 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 2 calcium ions per subunit. ; Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Secreted Belongs to the pentraxin family. complement component C1q binding extracellular region extracellular space complement activation, classical pathway low-density lipoprotein particle binding innate immune response metal ion binding uc029qus.1 uc029qus.2 uc029qus.3 
ENSMUST00000111230.8 Tagln2 ENSMUST00000111230.8 transgelin 2 (from RefSeq NM_178598.2) ENSMUST00000111230.1 ENSMUST00000111230.2 ENSMUST00000111230.3 ENSMUST00000111230.4 ENSMUST00000111230.5 ENSMUST00000111230.6 ENSMUST00000111230.7 Kiaa0120 NM_178598 Q3TIB8 Q6A0C6 Q78ZX2 Q91VU2 Q9WVA4 TAGL2_MOUSE uc007dqp.1 uc007dqp.2 uc007dqp.3 Belongs to the calponin family. Sequence=BAD32170.1; Type=Erroneous initiation; Evidence=; epithelial cell differentiation uc007dqp.1 uc007dqp.2 uc007dqp.3 
ENSMUST00000111234.10 Tnfrsf19 ENSMUST00000111234.10 tumor necrosis factor receptor superfamily, member 19, transcript variant 1 (from RefSeq NM_013869.5) ENSMUST00000111234.1 ENSMUST00000111234.2 ENSMUST00000111234.3 ENSMUST00000111234.4 ENSMUST00000111234.5 ENSMUST00000111234.6 ENSMUST00000111234.7 ENSMUST00000111234.8 ENSMUST00000111234.9 NM_013869 Q80T13 Q812G3 Q9JHF1 Q9JJH6 Q9JLL2 Q9JLL3 Q9QXW7 TNR19_MOUSE Taj Troy uc007ufj.1 uc007ufj.2 uc007ufj.3 uc007ufj.4 Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death (By similarity). Isoform 2 and isoform 3 may act as decoy receptors. Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1. Q9JLL3; P30086: PEBP1; Xeno; NbExp=4; IntAct=EBI-20800437, EBI-716384; Q9JLL3; P35232: PHB1; Xeno; NbExp=3; IntAct=EBI-20800437, EBI-354213; [Isoform 1]: Cell membrane ; Single- pass type I membrane protein [Isoform 3]: Cell membrane ; Single- pass type I membrane protein [Isoform 4]: Cell membrane ; Single- pass type I membrane protein [Isoform 2]: Secreted Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=TAJ-alphaL; IsoId=Q9JLL3-1; Sequence=Displayed; Name=2; Synonyms=TAJ-beta1; IsoId=Q9JLL3-2; Sequence=VSP_006513, VSP_006514; Name=3; Synonyms=TAJ-alphaS, dTROY; IsoId=Q9JLL3-3; Sequence=VSP_006515, VSP_006516; Name=4; IsoId=Q9JLL3-4; Sequence=VSP_006517, VSP_006518; Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver. hair follicle development protein binding extracellular region plasma membrane membrane integral component of membrane signaling receptor activity positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade uc007ufj.1 uc007ufj.2 uc007ufj.3 uc007ufj.4 
ENSMUST00000111238.8 Ttc17 ENSMUST00000111238.8 tetratricopeptide repeat domain 17, transcript variant 1 (from RefSeq NM_183106.2) E9PVB5 ENSMUST00000111238.1 ENSMUST00000111238.2 ENSMUST00000111238.3 ENSMUST00000111238.4 ENSMUST00000111238.5 ENSMUST00000111238.6 ENSMUST00000111238.7 NM_183106 Q4VBE5 Q5RKR1 TTC17_MOUSE uc008lgu.1 uc008lgu.2 uc008lgu.3 Plays a role in primary ciliogenesis by modulating actin polymerization. Interacts with CATIP. Cytoplasm Cell membrane Cytoplasm, cytoskeleton Note=Localized with CATIP at F-actin rich zones and at dynamic plasma membrane protrusions. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9PVB5-1; Sequence=Displayed; Name=2; IsoId=E9PVB5-2; Sequence=VSP_053920; Belongs to the TTC17 family. molecular_function cytoplasm cytosol cytoskeleton plasma membrane actin cytoskeleton membrane cell projection organization actin filament polymerization cilium organization uc008lgu.1 uc008lgu.2 uc008lgu.3 
ENSMUST00000111243.2 Atp1a4 ENSMUST00000111243.2 ATPase, Na+/K+ transporting, alpha 4 polypeptide (from RefSeq NM_013734.1) AT1A4_MOUSE Atp1a4 Atp1al2 E9QKL5 ENSMUST00000111243.1 NM_013734 Q9R173 Q9WV27 Q9WV28 uc011wwk.1 uc011wwk.2 uc011wwk.3 This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility (By similarity). Reaction=ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate; Xref=Rhea:RHEA:18353, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18354; Evidence=; Specifically inhibited by an endogenous cardiac glycoside, ouabain. The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Cell membrane; Multi-pass membrane protein. Expressed at high levels in the testis and at low levels in the epididymis. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. nucleotide binding sodium:potassium-exchanging ATPase activity ATP binding plasma membrane ion transport potassium ion transport sodium ion transport cellular sodium ion homeostasis spermatogenesis potassium-transporting ATPase activity fertilization establishment or maintenance of transmembrane electrochemical gradient membrane integral component of membrane cellular potassium ion homeostasis flagellated sperm motility regulation of cellular pH sodium ion export from cell regulation of membrane potential metal ion binding potassium ion import across plasma membrane uc011wwk.1 uc011wwk.2 uc011wwk.3 
ENSMUST00000111245.9 Gtf2ird1 ENSMUST00000111245.9 general transcription factor II I repeat domain-containing 1, transcript variant 6 (from RefSeq NM_001081466.2) Ben ENSMUST00000111245.1 ENSMUST00000111245.2 ENSMUST00000111245.3 ENSMUST00000111245.4 ENSMUST00000111245.5 ENSMUST00000111245.6 ENSMUST00000111245.7 ENSMUST00000111245.8 GT2D1_MOUSE NM_001081466 Q547E0 Q80WJ8 Q80WJ9 Q80WK0 Q80WK1 Q8R4X5 Q8R4X6 Q8R4X7 Q8R4X8 Q8VHD5 Q8VI58 Q9EQE7 Q9ESZ6 Q9ESZ7 Q9JI57 uc008zvw.1 uc008zvw.2 uc008zvw.3 uc008zvw.4 May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow- twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8. Interacts with the retinoblastoma protein (RB1) via its C- terminus. Nucleus Event=Alternative splicing; Named isoforms=10; Name=2; Synonyms=Beta, 3b7; IsoId=Q9JI57-1; Sequence=Displayed; Name=1; Synonyms=Alpha, 3a7; IsoId=Q9JI57-2; Sequence=VSP_003876; Name=3; Synonyms=Gamma, 1a1; IsoId=Q9JI57-3; Sequence=VSP_003874, VSP_003875, VSP_003876; Name=4; Synonyms=1b1; IsoId=Q9JI57-4; Sequence=VSP_003874, VSP_003875; Name=5; Synonyms=3b5; IsoId=Q9JI57-5; Sequence=VSP_003874; Name=6; Synonyms=3b3; IsoId=Q9JI57-6; Sequence=VSP_021376, VSP_003874; Name=7; Synonyms=3a3; IsoId=Q9JI57-7; Sequence=VSP_021376, VSP_003874, VSP_003876; Name=8; Synonyms=1b4; IsoId=Q9JI57-8; Sequence=VSP_003875; Name=9; Synonyms=2a5; IsoId=Q9JI57-9; Sequence=VSP_021377, VSP_003876; Name=10; Synonyms=1a4; IsoId=Q9JI57-10; Sequence=VSP_003875, VSP_003876; Widely expressed. Expressed in somites, neural tube and brain at 8- 8.5 dpc. Expression remains constant from 9.5-12.5 dpc with highest expression levels in the limb buds, branchial arches, crainofacial area, brain and spinal cord. Belongs to the TFII-I family. Sequence=AAF78367.1; Type=Frameshift; Evidence=; DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development transition between slow and fast fiber uc008zvw.1 uc008zvw.2 uc008zvw.3 uc008zvw.4 
ENSMUST00000111246.8 Accs ENSMUST00000111246.8 1-aminocyclopropane-1-carboxylate synthase (inactive), transcript variant 1 (from RefSeq NM_001290782.1) 1A1L1_MOUSE A2AIG8 ENSMUST00000111246.1 ENSMUST00000111246.2 ENSMUST00000111246.3 ENSMUST00000111246.4 ENSMUST00000111246.5 ENSMUST00000111246.6 ENSMUST00000111246.7 NM_001290782 Q8CHS6 uc008lgk.1 uc008lgk.2 uc008lgk.3 uc008lgk.4 uc008lgk.5 Does not catalyze the synthesis of 1-aminocyclopropane-1- carboxylate but is capable of catalyzing the deamination of L- vinylglycine. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AIG8-1; Sequence=Displayed; Name=2 ; IsoId=A2AIG8-2; Sequence=VSP_052669; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Similar to plant 1-aminocyclopropane-1-carboxylate synthases but lacks a number of residues which are necessary for activity. catalytic activity cellular_component biological_process biosynthetic process pyridoxal phosphate binding identical protein binding uc008lgk.1 uc008lgk.2 uc008lgk.3 uc008lgk.4 uc008lgk.5 
ENSMUST00000111263.9 Vangl2 ENSMUST00000111263.9 Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (PubMed:16495441). (from UniProt Q91ZD4) BC075636 ENSMUST00000111263.1 ENSMUST00000111263.2 ENSMUST00000111263.3 ENSMUST00000111263.4 ENSMUST00000111263.5 ENSMUST00000111263.6 ENSMUST00000111263.7 ENSMUST00000111263.8 Lpp1 Ltap Q91ZD4 Q923Z8 VANG2_MOUSE uc287nwf.1 uc287nwf.2 Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (PubMed:16495441). Homodimer and heterodimer with Vangl1. Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Variants Glu-255 and Asn-464 impair interaction with the DVL proteins. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3 (PubMed:15195140). Interacts with PRICKLE3 (By similarity). Q91ZD4; Q8R4A3: Dact1; NbExp=3; IntAct=EBI-1750744, EBI-3870250; Q91ZD4; P51141: Dvl1; NbExp=2; IntAct=EBI-1750744, EBI-1538407; Q91ZD4; Q60838: Dvl2; NbExp=4; IntAct=EBI-1750744, EBI-641940; Q91ZD4; Q61062: Dvl3; NbExp=2; IntAct=EBI-1750744, EBI-1538450; Q91ZD4; P31016: Dlg4; Xeno; NbExp=6; IntAct=EBI-1750744, EBI-375655; Cell membrane ; Multi-pass membrane protein Primarily expressed in the brain and epididymis. Not detected in the cochlea of Lp mice. In the embryo, strongly expressed in the neuroectoderm from the earliest stages of neural induction through the late stages of neural tube closure. Detected in the dorso-ventral axis of the neural tube, but not in the floor plate. Expression is low at day 7 dpc; it peaks at 11 dpc, and it remains strong at 15 dpc and 17 dpc. Also expressed in the cochlear epithelium at days 14.5 dpc and 16.5 dpc. Detected at low levels in the outflow tract myocardium from 9.5 dpc with levels increasing by 11.5 dpc. Note=Defects in Vangl2 are a cause of the loop-tail (Lp) mutant phenotype. Heterozygous Lp mice exhibit a characteristic looped tail, while homozygous embryos show a completely open neural tube in the hindbrain and spinal region, a condition similar to the severe craniorachischisis defect in humans. Homozygotes also have complex cardiovascular defects including double-outlet right ventricle, perimembranous ventricular defects, double-sided aortic arch and associated abnormalities in the aortic arch arteries. Homozygotes show cytoplasmic accumulation of Vangl2 instead of the normal membrane localization, and Rhoa expression, which is detected in the mesenchymal cushion cells adjacent to the outflow tract, is lost in homozygotes. Homozygous embryos typically die shortly before or at birth. Belongs to the Vang family. branching involved in blood vessel morphogenesis stress fiber establishment of planar polarity neural tube closure hair follicle development heart looping outflow tract septum morphogenesis membranous septum morphogenesis muscular septum morphogenesis epicardial cell to mesenchymal cell transition planar cell polarity pathway involved in axis elongation protein binding plasma membrane cell-cell junction Rho protein signal transduction multicellular organism development anterior/posterior pattern specification heparan sulfate proteoglycan biosynthetic process membrane integral component of membrane basolateral plasma membrane apical plasma membrane lateral plasma membrane convergent extension involved in neural plate elongation regulation of Wnt signaling pathway ER to Golgi transport vesicle glomerulus development regulation of actin cytoskeleton organization somatic stem cell population maintenance non-canonical Wnt signaling pathway cell migration involved in kidney development post-anal tail morphogenesis dopaminergic neuron axon guidance serotonergic neuron axon guidance wound healing positive regulation of JUN kinase activity apical protein localization establishment or maintenance of epithelial cell apical/basal polarity somatic stem cell division establishment of body hair planar orientation digestive tract morphogenesis convergent extension involved in axis elongation convergent extension involved in organogenesis Wnt signaling pathway, planar cell polarity pathway inner ear receptor cell development inner ear receptor stereocilium organization cell pole orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis planar dichotomous subdivision of terminal units involved in lung branching morphogenesis lateral sprouting involved in lung morphogenesis cardiac vascular smooth muscle cell differentiation kidney morphogenesis planar cell polarity pathway involved in heart morphogenesis cell periphery cochlea development cochlea morphogenesis establishment of epithelial cell polarity regulation of establishment of planar polarity establishment of planar polarity involved in neural tube closure planar cell polarity pathway involved in neural tube closure planar cell polarity pathway involved in axon guidance non-motile cilium assembly uc287nwf.1 uc287nwf.2 
ENSMUST00000111265.9 Tspan18 ENSMUST00000111265.9 tetraspanin 18 (from RefSeq NM_183180.2) ENSMUST00000111265.1 ENSMUST00000111265.2 ENSMUST00000111265.3 ENSMUST00000111265.4 ENSMUST00000111265.5 ENSMUST00000111265.6 ENSMUST00000111265.7 ENSMUST00000111265.8 NM_183180 Q80WR1 TSN18_MOUSE Tspan18 uc012bzr.1 uc012bzr.2 Plays a role in the cell surface localization of ORAI1 and may participate in the regulation of Ca(2+) signaling and the VWF release in response to inflammatory stimuli. Interacts with ORAI1; this interaction regulates ORAI1 exit from the endoplasmic (ER), and/or Golgi, and trafficking to the cell surface. Membrane ; Multi-pass membrane protein Highly expressed in lung (PubMed:15489334). Expressed in adult heart, artery and vein (PubMed:32694189). At 10.5 dpc embryo expressed in the developing heart (PubMed:32694189). At 13.5 dpc embryo expressed in intersomatic vessel (PubMed:32694189). Homozygote knockout mice lacking Tspan18 are viables. Belongs to the tetraspanin (TM4SF) family. molecular_function integral component of plasma membrane membrane integral component of membrane uc012bzr.1 uc012bzr.2 
ENSMUST00000111266.8 Trp53i11 ENSMUST00000111266.8 Membrane ; Multi-pass membrane protein (from UniProt Q4QQM4) BC098206 ENSMUST00000111266.1 ENSMUST00000111266.2 ENSMUST00000111266.3 ENSMUST00000111266.4 ENSMUST00000111266.5 ENSMUST00000111266.6 ENSMUST00000111266.7 P5I11_MOUSE Pig11 Q3UQL4 Q4QQM4 Tp53i11 uc008lfs.1 uc008lfs.2 uc008lfs.3 Membrane ; Multi-pass membrane protein Sequence=BAE25025.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008lfs.1 uc008lfs.2 uc008lfs.3 
ENSMUST00000111275.8 Ncf1 ENSMUST00000111275.8 neutrophil cytosolic factor 1, transcript variant 2 (from RefSeq NM_010876.4) ENSMUST00000111275.1 ENSMUST00000111275.2 ENSMUST00000111275.3 ENSMUST00000111275.4 ENSMUST00000111275.5 ENSMUST00000111275.6 ENSMUST00000111275.7 NCF1_MOUSE NM_010876 O70144 Q09014 Q3UE58 Q9JI34 uc008zvh.1 uc008zvh.2 uc008zvh.3 uc008zvh.4 uc008zvh.5 NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts (via C-terminus) with NCF2 (via the C-terminal SH3 domain). Interacts with NCF4. Interacts with CYBB. Interacts (via the second SH3 domain) with CYBA. Interacts with NOXA1. Interacts with ADAM15. Interacts with TRAF4. Interacts with FASLG (By similarity). Interacts with PARK7 (via C-terminus); the interaction is enhanced by LPS and modulates NCF1 phosphorylation and membrane translocation (PubMed:26021615). Interacts with NOXA1 (PubMed:16814099). Cytoplasm, cytosol Membrane ; Peripheral membrane protein ; Cytoplasmic side The PX domain mediates interaction with phosphatidylinositol 3,4-bisphosphate and other anionic phospholipids. In the autoinhibited, unphosphorylated state an intramolecular interaction with the C- terminal SH3 domain precludes phospholipid binding and interaction with CYBA. Phosphorylation disrupts the autoinhibited state (By similarity). Phosphorylated by PRKCD; phosphorylation induces activation of NCF1 and NADPH oxidase activity. response to yeast leukocyte mediated cytotoxicity respiratory burst involved in defense response protein binding cytoplasm rough endoplasmic reticulum Golgi apparatus cytosol plasma membrane protein targeting to membrane leukotriene metabolic process NADP catabolic process superoxide metabolic process apoptotic process inflammatory response cellular defense response cell proliferation lipid binding response to bacterium positive regulation of phosphatidylinositol 3-kinase signaling membrane superoxide-generating NADPH oxidase activity superoxide-generating NADPH oxidase activator activity SH3 domain binding extrinsic component of membrane dendrite cellular response to reactive oxygen species phosphatidylinositol binding superoxide anion generation defense response to bacterium NADPH oxidase complex neuronal cell body phosphatidylinositol-3,4-bisphosphate binding respiratory burst positive regulation of epidermal growth factor-activated receptor activity positive regulation of transcription, DNA-templated positive regulation of JNK cascade hydrogen peroxide biosynthetic process defense response to Gram-positive bacterium defense response to fungus oxidation-reduction process neutrophil mediated killing of gram-positive bacterium neutrophil mediated killing of fungus cellular response to cadmium ion positive regulation of p38MAPK cascade uc008zvh.1 uc008zvh.2 uc008zvh.3 uc008zvh.4 uc008zvh.5 
ENSMUST00000111284.9 Large2 ENSMUST00000111284.9 Reaction=3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3- beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr- [protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA- (1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)- beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP; Xref=Rhea:RHEA:57336, Rhea:RHEA-COMP:17482, Rhea:RHEA-COMP:17483, ChEBI:CHEBI:15378, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:177336, ChEBI:CHEBI:177352; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57337; Evidence=; (from UniProt A2AHG6) A2AHG6 A2AHG6_MOUSE BC058199 ENSMUST00000111284.1 ENSMUST00000111284.2 ENSMUST00000111284.3 ENSMUST00000111284.4 ENSMUST00000111284.5 ENSMUST00000111284.6 ENSMUST00000111284.7 ENSMUST00000111284.8 Large2 uc289ynq.1 uc289ynq.2 Reaction=3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3- beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr- [protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA- (1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)- beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP; Xref=Rhea:RHEA:57336, Rhea:RHEA-COMP:17482, Rhea:RHEA-COMP:17483, ChEBI:CHEBI:15378, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:177336, ChEBI:CHEBI:177352; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57337; Evidence=; Reaction=3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta- D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc- (1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)- beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D- GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP; Xref=Rhea:RHEA:67924, Rhea:RHEA-COMP:17484, Rhea:RHEA-COMP:17486, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:177354, ChEBI:CHEBI:177355; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67925; Evidence=; Reaction=3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA- (1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc- (1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP- alpha-D-xylose = 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA- (1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc- (1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP; Xref=Rhea:RHEA:68368, Rhea:RHEA-COMP:17485, Rhea:RHEA- COMP:17486, ChEBI:CHEBI:15378, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:177354, ChEBI:CHEBI:177355; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68369; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Membrane ; Single- pass type II membrane protein In the C-terminal section; belongs to the glycosyltransferase 49 family. In the N-terminal section; belongs to the glycosyltransferase 8 family. transferase activity transferase activity, transferring glycosyl groups uc289ynq.1 uc289ynq.2 
ENSMUST00000111288.4 Caln1 ENSMUST00000111288.4 calneuron 1, transcript variant 2 (from RefSeq NM_021371.2) CABP8_MOUSE Cabp8 ENSMUST00000111288.1 ENSMUST00000111288.2 ENSMUST00000111288.3 F8WHE1 MNCb-0849 NM_021371 Q9JJG7 uc008zup.1 uc008zup.2 uc008zup.3 uc008zup.4 Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning. Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner. Golgi apparatus, trans-Golgi network membrane ; Single-pass type IV membrane protein Cytoplasm, perinuclear region Cell membrane ; Single-pass type IV membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JJG7-1; Sequence=Displayed; Name=2; IsoId=Q9JJG7-2; Sequence=VSP_060874; Brain-specific. High expression in the cerebellum, hippocampus, and cortex. Shows little prenatal expression, with highest expression at postnatal day 21. The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting. Sequence=AAK15156.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; calcium ion binding cytoplasm Golgi apparatus plasma membrane biological_process membrane integral component of membrane trans-Golgi network membrane metal ion binding perinuclear region of cytoplasm uc008zup.1 uc008zup.2 uc008zup.3 uc008zup.4 
ENSMUST00000111289.8 Nit1 ENSMUST00000111289.8 nitrilase 1, transcript variant 4 (from RefSeq NM_001420682.1) ENSMUST00000111289.1 ENSMUST00000111289.2 ENSMUST00000111289.3 ENSMUST00000111289.4 ENSMUST00000111289.5 ENSMUST00000111289.6 ENSMUST00000111289.7 NIT1_MOUSE NM_001420682 Nit1 O88526 Q8VDK1 Q9R1N4 uc007dob.1 uc007dob.2 uc007dob.3 uc007dob.4 Catalyzes the hydrolysis of the amide bond in N-(4- oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Possesses amidase activity toward deaminated ophthalmate in vitro (PubMed:28373563). Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Reaction=H2O + N-(4-oxoglutaryl)-L-cysteinylglycine = 2-oxoglutarate + L-cysteinylglycine; Xref=Rhea:RHEA:54532, ChEBI:CHEBI:15377, ChEBI:CHEBI:16810, ChEBI:CHEBI:61694, ChEBI:CHEBI:138256; EC=3.5.1.128; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54533; Evidence=; Reaction=H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine = 2- oxoglutarate + N-(2-aminobutanoyl)glycine; Xref=Rhea:RHEA:17125, ChEBI:CHEBI:15377, ChEBI:CHEBI:16810, ChEBI:CHEBI:144697, ChEBI:CHEBI:144699; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17127; Evidence=; Kinetic parameters: KM=0.17 mM for N-(4-oxoglutarate)-L-cysteinylglycine (at pH 8.5) ; Vmax=2.6 umol/min/mg enzyme with N-(4-oxoglutarate)-L- cysteinylglycine as substrate (at pH 8.5) ; Note=kcat is 1.6 sec(-1) with N-(4-oxoglutarate)-L-cysteinylglycine as substrate. ; [Isoform 1]: Mitochondrion [Isoform 2]: Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VDK1-1; Sequence=Displayed; Name=2; IsoId=Q8VDK1-2; Sequence=VSP_011548; Expressed in most tissues with higher expression in adult liver and kidney as well as in fetal adrenal gland and skeletal muscle. Mice are normal at birth as well as during growth. Mammary glands exhibit an increase in ductal and alveolar structures as well as more cyclin-D1 positive cells in mid-pregnancy. In the basal layer of epidermis, the number of cyclin-D1 positive cells is also higher. No lymphoid malignancy is observed. Kidney cells lacking Nit1 exhibit round and compact shapes, loss of lobular structure, higher cell density with increased S and G2/M cell populations. Cyclin D1 expression is increased, whereas differences in the other cell cycle-associated proteins appeared minimal. T-cells lacking NIT-1 display enhanced proliferation, elevated activation marker expression, accelerated cell cycle progression and aberrant expression of some cell cycle proteins. According to Rosetta Stone theory, the existence of a fusion protein in one genome predicts that the separate polypeptides expressed in other organisms function in the same cellular or biochemical pathway. In Drosophila melanogaster and Caenorhabditis elegans, NitFhit is a fusion protein composed of a C-terminal Fhit domain and a domain related to plant and bacterial nitrilase. Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. cytoplasm mitochondrion nitrogen compound metabolic process hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides uc007dob.1 uc007dob.2 uc007dob.3 uc007dob.4 
ENSMUST00000111293.9 Phf21a ENSMUST00000111293.9 PHD finger protein 21A, transcript variant 6 (from RefSeq NM_001362830.1) A0A498WGG5 A0A498WGG5_MOUSE ENSMUST00000111293.1 ENSMUST00000111293.2 ENSMUST00000111293.3 ENSMUST00000111293.4 ENSMUST00000111293.5 ENSMUST00000111293.6 ENSMUST00000111293.7 ENSMUST00000111293.8 NM_001362830 Phf21a uc289ymx.1 uc289ymx.2 metal ion binding uc289ymx.1 uc289ymx.2 
ENSMUST00000111300.8 Dedd ENSMUST00000111300.8 death effector domain-containing, transcript variant 12 (from RefSeq NM_001420637.1) DEDD_MOUSE ENSMUST00000111300.1 ENSMUST00000111300.2 ENSMUST00000111300.3 ENSMUST00000111300.4 ENSMUST00000111300.5 ENSMUST00000111300.6 ENSMUST00000111300.7 NM_001420637 Q7TQH8 Q9R227 Q9Z1L3 uc007dny.1 uc007dny.2 uc007dny.3 uc007dny.4 A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 (By similarity). Inhibits DNA transcription in vitro. Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2 (By similarity). Cytoplasm Nucleus, nucleolus Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli. Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells (By similarity). Ubiquitously expressed. Exists predominantly in a mono- or diubiquitinated form. DNA binding protein binding nucleus nucleolus cytoplasm apoptotic process spermatogenesis extrinsic apoptotic signaling pathway via death domain receptors negative regulation of protein catabolic process regulation of apoptotic process decidualization negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter uc007dny.1 uc007dny.2 uc007dny.3 uc007dny.4 
ENSMUST00000111315.9 Adamts4 ENSMUST00000111315.9 ADAM metallopeptidase with thrombospondin type 1 motif 4 (from RefSeq NM_172845.3) ATS4_MOUSE ENSMUST00000111315.1 ENSMUST00000111315.2 ENSMUST00000111315.3 ENSMUST00000111315.4 ENSMUST00000111315.5 ENSMUST00000111315.6 ENSMUST00000111315.7 ENSMUST00000111315.8 NM_172845 Q8BNJ2 Q8K384 uc007dnn.1 uc007dnn.2 uc007dnn.3 This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active zinc-dependent aggrecanase enzyme that degrades cartilage. [provided by RefSeq, Jul 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660821.23608.1, SRR1660813.225470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|- Ala-393' site (By similarity). Reaction=Glutamyl endopeptidase. Bonds cleaved include 370-Thr-Glu-Gly- Glu-|-Ala-Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan.; EC=3.4.24.82; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Interacts with SRPX2. Secreted, extracellular space, extracellular matrix In embryonic skeletal muscle, significantly increased levels between 13.5 dpc and 15.5 dpc with maximal expression observed at 15.5 dpc (PubMed:23233679). Decreased levels in postnatal skeletal muscle (PubMed:23233679). In myoblasts, up-regulated soon after induction of myoblast differentiation (PubMed:23233679). The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2- G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3- glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). Sequence=BAC38944.1; Type=Erroneous initiation; Evidence=; protease binding metalloendopeptidase activity protein binding extracellular region extracellular space proteolysis peptidase activity metallopeptidase activity nuclear speck hydrolase activity defense response to bacterium metal ion binding uc007dnn.1 uc007dnn.2 uc007dnn.3 
ENSMUST00000111321.8 Apoa2 ENSMUST00000111321.8 apolipoprotein A-II, transcript variant 5 (from RefSeq NR_131173.1) APOA2_MOUSE ENSMUST00000111321.1 ENSMUST00000111321.2 ENSMUST00000111321.3 ENSMUST00000111321.4 ENSMUST00000111321.5 ENSMUST00000111321.6 ENSMUST00000111321.7 NR_131173 P09813 Q3UKX6 Q61317 uc056yex.1 uc056yex.2 This gene encodes a component of high density lipoproteins (HDL). Mice lacking the encoded protein have low HDL-cholesterol levels, smaller HDL particles, increased clearance of triglyceride-rich lipoproteins and insulin hypersensitivity. Transgenic mice overexpressing the encoded protein have elevated levels of HDL-cholesterol and show increased susceptibility to atherosclerosis. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]. May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Monomer. Interacts with NAXE and NDRG1 (By similarity). Secreted Plasma. [Apolipoprotein A-II]: Mass=8709.2; Mass_error=0.071; Method=Electrospray; Note=Strain C57BL/6. Without methionine sulfoxide.; Evidence=; [Apolipoprotein A-II]: Mass=8719.5; Method=Electrospray; Note=Strain BALB/c. Without methionine sulfoxide.; Evidence=; [Apolipoprotein A-II]: Mass=8725.3; Mass_error=0.283; Method=Electrospray; Note=Strain C57BL/6. With 1 methionine sulfoxide.; Evidence=; [Apolipoprotein A-II]: Mass=8742; Method=Electrospray; Note=Strain C57BL/6. With 2 methionine sulfoxides.; Evidence=; [Apolipoprotein A-II]: Mass=8735.2; Method=Electrospray; Note=Strain BALB/c. With 1 methionine sulfoxide.; Evidence=; [Proapolipoprotein A-II]: Mass=9294; Mass_error=0.707; Method=Electrospray; Note=Strain C57BL/6. Without methionine sulfoxide.; Evidence=; [Proapolipoprotein A-II]: Mass=9304; Method=Electrospray; Note=Strain BALB/c. Without methionine sulfoxide.; Evidence=; Note=Defects in Apoa2 are the cause of senescence accelerated mouse (SAM), the senile amyloid is a mutated apolipoprotein A-II. The apo A-II stoichiometry in HDL molecules varies among inbred mice strains, because of structural polymorphisms affecting the apo A-II gene, which influence its translational efficiency. The sequence presented here is that of strain BALB/c and C3H/HeJ. Belongs to the apolipoprotein A2 family. negative regulation of cytokine secretion involved in immune response receptor binding lipid transporter activity phospholipid binding extracellular region extracellular space cytosol fatty acid metabolic process phosphatidylcholine biosynthetic process lipid transport high-density lipoprotein particle binding cholesterol metabolic process lipid binding phospholipid catabolic process response to glucose positive regulation of cholesterol esterification negative regulation of very-low-density lipoprotein particle remodeling cholesterol binding beta-glucoside transport protein oxidation peptidyl-methionine modification regulation of intestinal cholesterol absorption cholesterol transport heat shock protein binding animal organ regeneration phosphatidylcholine binding regulation of protein stability negative regulation of cholesterol transport cholesterol efflux phospholipid efflux apolipoprotein receptor binding very-low-density lipoprotein particle high-density lipoprotein particle spherical high-density lipoprotein particle triglyceride-rich lipoprotein particle remodeling low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling high-density lipoprotein particle assembly high-density lipoprotein particle clearance lipoprotein metabolic process chylomicron cholesterol homeostasis protein homodimerization activity positive regulation of catalytic activity reverse cholesterol transport positive regulation of interleukin-8 biosynthetic process diacylglycerol catabolic process protein heterodimerization activity positive regulation of phagocytosis protein stabilization negative regulation of lipid catabolic process positive regulation of lipid catabolic process lipase inhibitor activity negative regulation of lipase activity phosphatidylcholine-sterol O-acyltransferase activator activity negative regulation of cholesterol import negative regulation of cholesterol transporter activity high-density lipoprotein particle receptor binding uc056yex.1 uc056yex.2 
ENSMUST00000111325.5 Sdr39u1 ENSMUST00000111325.5 short chain dehydrogenase/reductase family 39U, member 1, transcript variant 2 (from RefSeq NM_001374224.1) D39U1_MOUSE ENSMUST00000111325.1 ENSMUST00000111325.2 ENSMUST00000111325.3 ENSMUST00000111325.4 NM_001374224 Q3V467 Q5M8N4 Q8BWX0 uc007ubd.1 uc007ubd.2 uc007ubd.3 Putative NADP-dependent oxidoreductase. Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. Sequence=AAH87941.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; molecular_function catalytic activity biological_process oxidoreductase activity coenzyme binding oxidation-reduction process uc007ubd.1 uc007ubd.2 uc007ubd.3 
ENSMUST00000111329.8 Arhgap1 ENSMUST00000111329.8 Rho GTPase activating protein 1, transcript variant 4 (from RefSeq NR_027372.1) ENSMUST00000111329.1 ENSMUST00000111329.2 ENSMUST00000111329.3 ENSMUST00000111329.4 ENSMUST00000111329.5 ENSMUST00000111329.6 ENSMUST00000111329.7 NR_027372 Q5FWK3 Q8C3X5 Q923D8 RHG01_MOUSE uc008kwi.1 uc008kwi.2 uc008kwi.3 uc008kwi.4 uc008kwi.5 GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL (By similarity). Cytoplasm ruffle GTPase activator activity protein binding cytoplasm plasma membrane signal transduction small GTPase mediated signal transduction endosome membrane endosomal transport SH3 domain binding Rab GTPase binding cell leading edge transferrin transport regulation of GTPase activity positive regulation of GTPase activity perinuclear region of cytoplasm negative regulation of endocytic recycling sorting endosome uc008kwi.1 uc008kwi.2 uc008kwi.3 uc008kwi.4 uc008kwi.5 
ENSMUST00000111332.2 Pcp4l1 ENSMUST00000111332.2 Purkinje cell protein 4-like 1 (from RefSeq NM_025557.1) ENSMUST00000111332.1 NM_025557 PC4L1_MOUSE Q6W8Q3 Q9CW92 uc009uzy.1 uc009uzy.2 uc009uzy.3 Expressed in laminar and nuclear structures of the CNS. First detected at 9.5 dpc in the neural tube. Expressed at early stages of development in the isthmus and in metencephalic and mesencephalic roof plates. At later stages of development, it is expressed in structures corresponding to circumventricular organs which in adult control the production of the cerebrospinal fluid. Belongs to the PCP4 family. Sequence=BAB22346.1; Type=Erroneous initiation; Evidence=; Sequence=BAC27734.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc009uzy.1 uc009uzy.2 uc009uzy.3 
ENSMUST00000111336.10 Sdhc ENSMUST00000111336.10 succinate dehydrogenase complex, subunit C, integral membrane protein (from RefSeq NM_025321.3) C560_MOUSE ENSMUST00000111336.1 ENSMUST00000111336.2 ENSMUST00000111336.3 ENSMUST00000111336.4 ENSMUST00000111336.5 ENSMUST00000111336.6 ENSMUST00000111336.7 ENSMUST00000111336.8 ENSMUST00000111336.9 NM_025321 Q544Q9 Q99JP2 Q9CZB0 Q9DCU7 uc007dnb.1 uc007dnb.2 uc007dnb.3 uc007dnb.4 Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=The heme b is bound between the two transmembrane subunits SDHC and SDHD. ; Carbohydrate metabolism; tricarboxylic acid cycle. Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the cytochrome b560 family. succinate dehydrogenase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) tricarboxylic acid cycle mitochondrial electron transport, succinate to ubiquinone electron carrier activity membrane integral component of membrane oxidoreductase activity, acting on the CH-CH group of donors heme binding succinate dehydrogenase complex metal ion binding oxidation-reduction process uc007dnb.1 uc007dnb.2 uc007dnb.3 uc007dnb.4 
ENSMUST00000111338.10 Ckap5 ENSMUST00000111338.10 cytoskeleton associated protein 5, transcript variant 1 (from RefSeq NM_001165989.2) Ckap5 ENSMUST00000111338.1 ENSMUST00000111338.2 ENSMUST00000111338.3 ENSMUST00000111338.4 ENSMUST00000111338.5 ENSMUST00000111338.6 ENSMUST00000111338.7 ENSMUST00000111338.8 ENSMUST00000111338.9 K3W4R5 K3W4R5_MOUSE NM_001165989 uc008kwb.1 uc008kwb.2 uc008kwb.3 Chromosome, centromere, kinetochore Belongs to the TOG/XMAP215 family. kinetochore spindle pole gamma-tubulin complex nucleolus centrosome plasma membrane spindle organization centrosome cycle establishment or maintenance of microtubule cytoskeleton polarity macromolecular complex microtubule plus-end uc008kwb.1 uc008kwb.2 uc008kwb.3 
ENSMUST00000111346.6 Rimbp2 ENSMUST00000111346.6 RIMS binding protein 2, transcript variant 1 (from RefSeq NM_001081388.2) D3YXR8 D3YXR8_MOUSE ENSMUST00000111346.1 ENSMUST00000111346.2 ENSMUST00000111346.3 ENSMUST00000111346.4 ENSMUST00000111346.5 NM_001081388 Rimbp2 uc008zsl.1 uc008zsl.2 uc008zsl.3 uc008zsl.4 Belongs to the RIMBP family. negative regulation of phosphatase activity uc008zsl.1 uc008zsl.2 uc008zsl.3 uc008zsl.4 
ENSMUST00000111354.2 Nr1h3 ENSMUST00000111354.2 nuclear receptor subfamily 1, group H, member 3, transcript variant 3 (from RefSeq NM_001355279.1) ENSMUST00000111354.1 Lxra NM_001355279 NR1H3_MOUSE Q9QUH7 Q9Z0Y9 uc008kvd.1 uc008kvd.2 uc008kvd.3 uc008kvd.4 Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (PubMed:28846071, PubMed:25806685). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (PubMed:25806685). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (PubMed:24206663). Heterodimer of NR1H3 and RXR (retinoic acid receptor). Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts with SIRT1 and this interaction is inhibited by CCAR2 (By similarity). Q9Z0Y9; O88559: Men1; NbExp=3; IntAct=EBI-5276764, EBI-3990176; Q9Z0Y9; Q96EB6: SIRT1; Xeno; NbExp=2; IntAct=EBI-5276764, EBI-1802965; Nucleus toplasm Ubiquitinated leading to its degradation by the proteasome. Belongs to the nuclear hormone receptor family. NR1 subfamily. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated lipid metabolic process fatty acid biosynthetic process multicellular organism development transcription factor binding zinc ion binding positive regulation of triglyceride biosynthetic process positive regulation of receptor biosynthetic process positive regulation of cholesterol efflux negative regulation of cholesterol storage cell differentiation ligand-dependent nuclear receptor transcription coactivator activity intracellular receptor signaling pathway positive regulation of cellular protein metabolic process negative regulation of lipid transport positive regulation of cholesterol transport response to progesterone sterol response element binding positive regulation of toll-like receptor 4 signaling pathway signaling receptor activity cholesterol homeostasis negative regulation of macrophage activation receptor complex apoptotic cell clearance steroid hormone mediated signaling pathway sequence-specific DNA binding transcription regulatory region DNA binding cellular lipid metabolic process positive regulation of fatty acid biosynthetic process negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding retinoid X receptor binding protein heterodimerization activity negative regulation of pinocytosis negative regulation of inflammatory response positive regulation of lipoprotein lipase activity lipid homeostasis sterol homeostasis triglyceride homeostasis cellular response to lipopolysaccharide negative regulation of pancreatic juice secretion negative regulation of secretion of lysosomal enzymes RNA polymerase II transcription factor complex regulation of ligand-dependent nuclear receptor transcription coactivator activity uc008kvd.1 uc008kvd.2 uc008kvd.3 uc008kvd.4 
ENSMUST00000111360.3 ENSMUSG00000079190 ENSMUST00000111360.3 ENSMUSG00000079190 (from geneSymbol) AK163341 ENSMUST00000111360.1 ENSMUST00000111360.2 uc008idh.1 uc008idh.2 uc008idh.3 uc008idh.1 uc008idh.2 uc008idh.3 
ENSMUST00000111364.3 ENSMUSG00000079192 ENSMUST00000111364.3 ENSMUSG00000079192 (from geneSymbol) ENSMUST00000111364.1 ENSMUST00000111364.2 uc289soz.1 uc289soz.2 uc289soz.1 uc289soz.2 
ENSMUST00000111368.8 Nuf2 ENSMUST00000111368.8 NUF2, NDC80 kinetochore complex component, transcript variant 1 (from RefSeq NM_023284.3) Cdca1 ENSMUST00000111368.1 ENSMUST00000111368.2 ENSMUST00000111368.3 ENSMUST00000111368.4 ENSMUST00000111368.5 ENSMUST00000111368.6 ENSMUST00000111368.7 NM_023284 NUF2_MOUSE Nuf2r Q8BTK7 Q8VE05 Q99P69 Q9CST5 uc007dlj.1 uc007dlj.2 Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end. May interact with AURKB/Aurora-B (By similarity). Nucleus Chromosome, centromere, kinetochore Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99P69-1; Sequence=Displayed; Name=2; IsoId=Q99P69-2; Sequence=VSP_020553, VSP_020554; Can be phosphorylated by AURKA and AURKB. Belongs to the NUF2 family. Sequence=BAC41008.1; Type=Frameshift; Evidence=; chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed nuclear chromosome kinetochore nucleus chromosome cell cycle mitotic spindle organization attachment of spindle microtubules to kinetochore Ndc80 complex macromolecular complex binding meiotic chromosome segregation cell division attachment of mitotic spindle microtubules to kinetochore kinetochore organization uc007dlj.1 uc007dlj.2 
ENSMUST00000111377.8 Lmx1a ENSMUST00000111377.8 LIM homeobox transcription factor 1 alpha, transcript variant 2 (from RefSeq NM_001417483.1) ENSMUST00000111377.1 ENSMUST00000111377.2 ENSMUST00000111377.3 ENSMUST00000111377.4 ENSMUST00000111377.5 ENSMUST00000111377.6 ENSMUST00000111377.7 LMX1A_MOUSE NM_001417483 Q9JKU8 uc287noj.1 uc287noj.2 Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae. Nucleus Note=Defects in Lmx1a are the cause of the spontaneous neurologic mutant mouse, called 'dreher' (dr) and results from a failure of the roof plate to develop. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding regulation of cell growth DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development axon guidance central nervous system development brain development memory locomotory behavior regulation of gene expression dentate gyrus development cerebellum development hippocampus development central nervous system neuron differentiation neuron differentiation midbrain development olfactory behavior sequence-specific DNA binding negative regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding synapse organization dopaminergic neuron differentiation positive regulation of canonical Wnt signaling pathway midbrain dopaminergic neuron differentiation positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation uc287noj.1 uc287noj.2 
ENSMUST00000111417.9 Zfp664 ENSMUST00000111417.9 zinc finger protein 664 (from RefSeq NM_001081750.2) E9QPD3 E9QPD3_MOUSE ENSMUST00000111417.1 ENSMUST00000111417.2 ENSMUST00000111417.3 ENSMUST00000111417.4 ENSMUST00000111417.5 ENSMUST00000111417.6 ENSMUST00000111417.7 ENSMUST00000111417.8 NM_001081750 Zfp664 uc008zqs.1 uc008zqs.2 uc008zqs.3 nucleic acid binding nucleus uc008zqs.1 uc008zqs.2 uc008zqs.3 
ENSMUST00000111423.3 ENSMUSG00000079222 ENSMUST00000111423.3 Sp110 nuclear body protein pseudogene (from RefSeq NR_131980.1) ENSMUST00000111423.1 ENSMUST00000111423.2 NR_131980 uc009oad.1 uc009oad.2 uc009oad.3 uc009oad.4 uc009oad.1 uc009oad.2 uc009oad.3 uc009oad.4 
ENSMUST00000111432.10 Creg1 ENSMUST00000111432.10 cellular repressor of E1A-stimulated genes 1, transcript variant 1 (from RefSeq NM_011804.3) CREG1_MOUSE Creg ENSMUST00000111432.1 ENSMUST00000111432.2 ENSMUST00000111432.3 ENSMUST00000111432.4 ENSMUST00000111432.5 ENSMUST00000111432.6 ENSMUST00000111432.7 ENSMUST00000111432.8 ENSMUST00000111432.9 NM_011804 O88668 Q3UNP8 Q8C3I1 uc007djm.1 uc007djm.2 uc007djm.3 May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R (By similarity). Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation (By similarity). Secreted Widely expressed. Found at low level from 7 dpc and increased during embryonic development. Induced during differentiation. N-glycosylated. Belongs to the CREG family. extracellular region extracellular space transcription factor complex regulation of transcription, DNA-templated transcription factor binding regulation of growth cofactor binding uc007djm.1 uc007djm.2 uc007djm.3 
ENSMUST00000111435.9 Mpzl1 ENSMUST00000111435.9 myelin protein zero-like 1, transcript variant 1 (from RefSeq NM_001083897.1) ENSMUST00000111435.1 ENSMUST00000111435.2 ENSMUST00000111435.3 ENSMUST00000111435.4 ENSMUST00000111435.5 ENSMUST00000111435.6 ENSMUST00000111435.7 ENSMUST00000111435.8 MPZL1_MOUSE NM_001083897 Pzr Q2VW02 Q3TEW6 Q6GQX5 uc007djh.1 uc007djh.2 uc007djh.3 Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 2 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2, may be involved in regulation of integrin-mediated cell motility (By similarity). Interacts with phosphorylated PTPN11/SHP-2. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TEW6-1; Sequence=Displayed; Name=2; Synonyms=b; IsoId=Q3TEW6-2; Sequence=VSP_019345; Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-242 and Tyr-264 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro) (By similarity). Belongs to the myelin P0 protein family. protein binding integral component of plasma membrane signal transduction membrane integral component of membrane positive regulation of cell migration uc007djh.1 uc007djh.2 uc007djh.3 
ENSMUST00000111440.8 Adcy10 ENSMUST00000111440.8 Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation. (from UniProt E9Q9T4) AK029849 Adcy10 E9Q9T4 E9Q9T4_MOUSE ENSMUST00000111440.1 ENSMUST00000111440.2 ENSMUST00000111440.3 ENSMUST00000111440.4 ENSMUST00000111440.5 ENSMUST00000111440.6 ENSMUST00000111440.7 uc287nkg.1 uc287nkg.2 Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation. Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence=; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding magnesium ion binding adenylate cyclase activity ATP binding cAMP biosynthetic process spermatogenesis cyclic nucleotide biosynthetic process lyase activity phosphorus-oxygen lyase activity intracellular signal transduction uc287nkg.1 uc287nkg.2 
ENSMUST00000111442.3 Ccr5 ENSMUST00000111442.3 C-C motif chemokine receptor 5 (from RefSeq NM_009917.5) CCR5_MOUSE Cmkbr5 ENSMUST00000111442.1 ENSMUST00000111442.2 NM_009917 O35313 O35891 P51682 P97308 P97405 Q3ZAZ8 Q61867 uc057aqm.1 uc057aqm.2 uc057aqm.3 Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. Interacts with PRAF2. Efficient ligand binding to CCL3/MIP- 1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4. Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis. Cell membrane; Multi-pass membrane protein. Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity). O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding (By similarity). Palmitoylation in the C-terminal is important for cell surface expression. Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES. Belongs to the G-protein coupled receptor 1 family. MAPK cascade actin binding G-protein coupled receptor activity chemokine receptor activity cytoplasm endosome plasma membrane calcium ion transport chemotaxis defense response inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling external side of plasma membrane cell surface positive regulation of gene expression release of sequestered calcium ion into cytosol by sarcoplasmic reticulum membrane integral component of membrane C-C chemokine receptor activity calcium-mediated signaling protein kinase binding chemokine binding C-C chemokine binding positive regulation of cell-cell adhesion signaling negative regulation of cell migration negative regulation of axon extension positive regulation of fever generation positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of neuron differentiation positive regulation of interleukin-1 beta secretion positive regulation of inflammatory response positive regulation of apoptotic process by virus cell chemotaxis chemokine-mediated signaling pathway response to cholesterol neuron death cellular response to lipopolysaccharide chemokine (C-C motif) ligand 5 binding negative regulation of macrophage apoptotic process negative regulation of neural precursor cell proliferation uc057aqm.1 uc057aqm.2 uc057aqm.3 
ENSMUST00000111450.3 Gpr161 ENSMUST00000111450.3 G protein-coupled receptor 161, transcript variant 3 (from RefSeq NM_001310430.1) A0A140T8Q9 A0A140T8Q9_MOUSE ENSMUST00000111450.1 ENSMUST00000111450.2 Gpr161 NM_001310430 uc011wuy.1 uc011wuy.2 uc011wuy.3 Cell membrane ; Multi-pass membrane protein Cell projection, cilium membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc011wuy.1 uc011wuy.2 uc011wuy.3 
ENSMUST00000111461.13 Ptpmt1 ENSMUST00000111461.13 protein tyrosine phosphatase, mitochondrial 1 (from RefSeq NM_025576.2) ENSMUST00000111461.1 ENSMUST00000111461.10 ENSMUST00000111461.11 ENSMUST00000111461.12 ENSMUST00000111461.2 ENSMUST00000111461.3 ENSMUST00000111461.4 ENSMUST00000111461.5 ENSMUST00000111461.6 ENSMUST00000111461.7 ENSMUST00000111461.8 ENSMUST00000111461.9 NM_025576 PTPM1_MOUSE Plip Ptpmt1 Q66GT5 Q9CSJ8 Q9D622 uc289yhh.1 uc289yhh.2 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (PubMed:21641550, PubMed:21730175). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (PubMed:21641550). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (By similarity). Reaction=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate; Xref=Rhea:RHEA:33751, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:60110, ChEBI:CHEBI:64716; EC=3.1.3.27; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33752; Evidence=; Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10685; Evidence=; Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20630; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47005; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol- 3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho- (1'-sn-glycerol) + phosphate; Xref=Rhea:RHEA:42304, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:75163, ChEBI:CHEBI:78907; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42305; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5- phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:42308, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:65221, ChEBI:CHEBI:78911; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42309; Evidence=; Reaction=a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5- phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:42320, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:78930, ChEBI:CHEBI:78931; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42321; Evidence=; Reaction=1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5- phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:42584, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:82605, ChEBI:CHEBI:82606; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42585; Evidence=; Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2. Interacts with STYXL1; the interaction inhibits PTPMT1 catalytic activity. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Predominantly expressed in testis. Expressed at lower level in heart, brain, spleen, lung, liver, skeletal muscle, kidney, bone marrow, eye, lymph node, smooth muscle, prostate, thymus, stomach and uterus. Mice die prior to E8.5. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. Was originally (PubMed:15247229) thought to have phosphatidylinositol 5-phosphatase activity, however, it was later shown (PubMed:16039589) that it is probably not the case in vivo. Sequence=AAH26750.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB28400.1; Type=Frameshift; Evidence=; Sequence=BAB29504.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity mitochondrion mitochondrial inner membrane protein dephosphorylation lipid metabolic process phosphatidylglycerol biosynthetic process protein tyrosine/serine/threonine phosphatase activity phospholipid biosynthetic process phosphatidylglycerophosphatase activity membrane dephosphorylation hydrolase activity phosphatase activity integral component of mitochondrial inner membrane cardiolipin biosynthetic process peptidyl-tyrosine dephosphorylation phosphatidylinositol metabolic process negative regulation of insulin secretion involved in cellular response to glucose stimulus regulation of intrinsic apoptotic signaling pathway uc289yhh.1 uc289yhh.2 
ENSMUST00000111466.3 C1qtnf4 ENSMUST00000111466.3 C1q and tumor necrosis factor related protein 4 (from RefSeq NM_026161.3) A2AFW1 C1QT4_MOUSE Ctrp4 ENSMUST00000111466.1 ENSMUST00000111466.2 NM_026161 Q4ZJN5 Q8R066 Q9D0W2 Q9DCB6 uc008ktq.1 uc008ktq.2 uc008ktq.3 May be involved in the regulation of the inflammatory network. The role as pro- or anti-inflammatory seems to be context dependent (By similarity). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 hours post-injection (Probable). Homomultimer. Forms trimers, hexamers and high molecular weight oligomers. Secreted High expression in testis, kidney, and brain. Expressed in brain and kidney (at protein level). Within the brain, highly expressed in cerebellum, cortex, hippocampus and hypothalamus, and lower expression in hindbrain (at protein level). Serum levels were increased in leptin-deficient ob/ob mice (a genetic model of hyperphagia and morbid obesity) relative to age-matched lean controls. No difference in serum levels were detected between mice fed a low-fat versus high-fat diet for 14 weeks (PubMed:24366864). Up-regulated during acute colitis induced by injection of dextran sulfate sodium (DSS). There are conflicting results in its involvement in the inflammatory network. It was first described to be a pro-inflammatory cytokine by inducing the activation of NF-kappa-B signaling pathway and up-regulates IL6 production in liver carcinoma cells. While it seems to have the opposite effect in macrophages. Involvement in food intake and energy was only observed when the protein was externally administered in the brain, but not when this protein was overexpressed in vivo (PubMed:24366864). Sequence=BAB22473.1; Type=Frameshift; Evidence=; Sequence=BAB23268.1; Type=Frameshift; Evidence=; molecular_function cytokine activity extracellular region extracellular space signal transduction positive regulation of interleukin-6 production positive regulation of interleukin-6-mediated signaling pathway positive regulation of NIK/NF-kappaB signaling positive regulation of tumor necrosis factor secretion positive regulation of interleukin-6 secretion uc008ktq.1 uc008ktq.2 uc008ktq.3 
ENSMUST00000111490.2 Mettl18 ENSMUST00000111490.2 methyltransferase like 18, transcript variant 2 (from RefSeq NM_001355132.1) ENSMUST00000111490.1 MET18_MOUSE Mettl18 NM_001355132 Q810I8 Q9CZ09 uc007dhv.1 uc007dhv.2 uc007dhv.3 uc007dhv.4 uc007dhv.5 Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation. Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins. Reaction=L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:19369, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:11600, ChEBI:CHEBI:15378, ChEBI:CHEBI:16367, ChEBI:CHEBI:29979, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.85; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19370; Evidence=; Interacts with GRWD1 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme. Cytoplasm, cytosol Nucleus Nucleus, nucleolus Monomethylated at His-144 through automethylation. Automethylation at His-144 positively regulates the methyltransferase activity toward RPL3. Probably methylated on other residues. Belongs to the methyltransferase superfamily. METTL18 family. biological_process methyltransferase activity transferase activity heat shock protein binding methylation macromolecular complex uc007dhv.1 uc007dhv.2 uc007dhv.3 uc007dhv.4 uc007dhv.5 
ENSMUST00000111495.9 Ptprj ENSMUST00000111495.9 protein tyrosine phosphatase receptor type J, transcript variant 2 (from RefSeq NM_001135657.1) A2AWF9 A2AWF9_MOUSE ENSMUST00000111495.1 ENSMUST00000111495.2 ENSMUST00000111495.3 ENSMUST00000111495.4 ENSMUST00000111495.5 ENSMUST00000111495.6 ENSMUST00000111495.7 ENSMUST00000111495.8 NM_001135657 Ptprj uc008ksu.1 uc008ksu.2 uc008ksu.3 uc008ksu.4 Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Membrane ; Single- pass type I membrane protein Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein dephosphorylation membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc008ksu.1 uc008ksu.2 uc008ksu.3 uc008ksu.4 
ENSMUST00000111508.9 Or4c127 ENSMUST00000111508.9 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGN2) ENSMUST00000111508.1 ENSMUST00000111508.2 ENSMUST00000111508.3 ENSMUST00000111508.4 ENSMUST00000111508.5 ENSMUST00000111508.6 ENSMUST00000111508.7 ENSMUST00000111508.8 Olfr1262 Or4c127 Q8VGN2 Q8VGN2_MOUSE or-leaf2 uc008ksh.1 uc008ksh.2 uc008ksh.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008ksh.1 uc008ksh.2 uc008ksh.3 
ENSMUST00000111512.10 Or4c35 ENSMUST00000111512.10 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGN9) ENSMUST00000111512.1 ENSMUST00000111512.2 ENSMUST00000111512.3 ENSMUST00000111512.4 ENSMUST00000111512.5 ENSMUST00000111512.6 ENSMUST00000111512.7 ENSMUST00000111512.8 ENSMUST00000111512.9 Olfr1260 Or4c35 Q8VGN9 Q8VGN9_MOUSE uc289yec.1 uc289yec.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yec.1 uc289yec.2 
ENSMUST00000111519.3 Or4c10b ENSMUST00000111519.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGP0) ENSMUST00000111519.1 ENSMUST00000111519.2 Olfr1257 Or4c10b Q8VGP0 Q8VGP0_MOUSE uc008ksc.1 uc008ksc.2 uc008ksc.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008ksc.1 uc008ksc.2 uc008ksc.3 
ENSMUST00000111525.8 Fmo4 ENSMUST00000111525.8 This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. (from UniProt Q8VHG0) AF461145 ENSMUST00000111525.1 ENSMUST00000111525.2 ENSMUST00000111525.3 ENSMUST00000111525.4 ENSMUST00000111525.5 ENSMUST00000111525.6 ENSMUST00000111525.7 FMO4_MOUSE Q8VHG0 uc007dgv.1 uc007dgv.2 uc007dgv.3 This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Reaction=H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N- dimethylaniline N-oxide + NADP(+); Xref=Rhea:RHEA:24468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16269, ChEBI:CHEBI:17735, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.8; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Microsome membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Belongs to the FMO family. monooxygenase activity N,N-dimethylaniline monooxygenase activity cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane oxidoreductase activity organelle membrane drug catabolic process intracellular membrane-bounded organelle flavin adenine dinucleotide binding NADP binding oxidation-reduction process uc007dgv.1 uc007dgv.2 uc007dgv.3 
ENSMUST00000111532.4 Or4a74 ENSMUST00000111532.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AT78) A2AT78 A2AT78_MOUSE ENSMUST00000111532.1 ENSMUST00000111532.2 ENSMUST00000111532.3 Olfr1247 Or4a74 uc008krs.1 uc008krs.2 uc008krs.3 uc008krs.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008krs.1 uc008krs.2 uc008krs.3 uc008krs.4 
ENSMUST00000111535.8 Amn1 ENSMUST00000111535.8 antagonist of mitotic exit network 1, transcript variant 6 (from RefSeq NR_167759.1) AMN1_MOUSE B8JKV0 ENSMUST00000111535.1 ENSMUST00000111535.2 ENSMUST00000111535.3 ENSMUST00000111535.4 ENSMUST00000111535.5 ENSMUST00000111535.6 ENSMUST00000111535.7 NR_167759 uc012evz.1 uc012evz.2 uc012evz.3 Interacts with TASOR. Expressed in the Sertoli cells of the testis. Belongs to the AMN1 family. ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein transferase activity uc012evz.1 uc012evz.2 uc012evz.3 
ENSMUST00000111546.8 Ablim1 ENSMUST00000111546.8 actin-binding LIM protein 1, transcript variant 2 (from RefSeq NM_001103177.3) ABLM1_MOUSE Ablim ENSMUST00000111546.1 ENSMUST00000111546.2 ENSMUST00000111546.3 ENSMUST00000111546.4 ENSMUST00000111546.5 ENSMUST00000111546.6 ENSMUST00000111546.7 Kiaa0059 NM_001103177 Q80U86 Q8BIR9 Q8K4G3 Q8K4G4 Q8K4G5 uc033hla.1 uc033hla.2 uc033hla.3 uc033hla.4 May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. Binds F-actin. Interacts with ABRA (By similarity). Q8K4G5; Q62108: Dlg4; NbExp=5; IntAct=EBI-2307994, EBI-300895; Cytoplasm Cytoplasm, cytoskeleton Note=In a striped pattern along the myofibril axis in cardiac myocytes. Associated with the cytoskeleton. Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=AbLIM-L; IsoId=Q8K4G5-1; Sequence=Displayed; Name=2; Synonyms=AbLIM-M; IsoId=Q8K4G5-2; Sequence=VSP_012104, VSP_012108, VSP_012110; Name=3; Synonyms=AbLIM-S; IsoId=Q8K4G5-3; Sequence=VSP_012103; Name=4; IsoId=Q8K4G5-4; Sequence=VSP_012104, VSP_012108, VSP_012110, VSP_012111; Name=5; IsoId=Q8K4G5-5; Sequence=VSP_012105, VSP_012106, VSP_012107, VSP_012109; Isoform 1 is detected in adult retina, where it is highly expressed in the ganglion layer. Detected in rod inner segment. Isoform 2 is highly expressed in adult retina, brain, kidney and heart. Isoform 3 is highly expressed in adult retina, brain, kidney, liver, skeletal muscle, spleen and heart. Detected in embryonic retina, brain, spinal cord, peripheral sensory ganglia and thymus. Isoform 1 is detected at low levels starting from 12 dpc and remains constant until birth. After this levels increase strongly and expression remains high in adults. Isoform 2 and isoform 3 are expressed at a constant high level throughout development. Isoform 1 is not necessary for normal axon guidance. Sequence=BAC65478.1; Type=Erroneous initiation; Evidence=; stress fiber actin binding protein binding cytoplasm cytoskeleton cytoskeleton organization axon guidance postsynaptic density actin cytoskeleton lamellipodium lamellipodium assembly positive regulation of transcription from RNA polymerase II promoter metal ion binding actin filament binding cilium assembly uc033hla.1 uc033hla.2 uc033hla.3 uc033hla.4 
ENSMUST00000111557.8 Dennd5b ENSMUST00000111557.8 DENN domain containing 5B (from RefSeq NM_177192.3) A2RSQ0 DEN5B_MOUSE ENSMUST00000111557.1 ENSMUST00000111557.2 ENSMUST00000111557.3 ENSMUST00000111557.4 ENSMUST00000111557.5 ENSMUST00000111557.6 ENSMUST00000111557.7 NM_177192 Q8BII7 Q8BWK2 uc009ett.1 uc009ett.2 uc009ett.3 Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Membrane ; Single-pass membrane protein Belongs to the RAB6IP1 family. Sequence=AAI32200.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=AAI32536.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=BAC34394.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; guanyl-nucleotide exchange factor activity membrane integral component of membrane Rab guanyl-nucleotide exchange factor activity uc009ett.1 uc009ett.2 uc009ett.3 
ENSMUST00000111566.9 Clip1 ENSMUST00000111566.9 CAP-GLY domain containing linker protein 1, transcript variant 1 (from RefSeq NM_019765.5) CLIP1_MOUSE ENSMUST00000111566.1 ENSMUST00000111566.2 ENSMUST00000111566.3 ENSMUST00000111566.4 ENSMUST00000111566.5 ENSMUST00000111566.6 ENSMUST00000111566.7 ENSMUST00000111566.8 Kiaa4046 NM_019765 Q571L7 Q922J3 Rsn uc008zoa.1 uc008zoa.2 uc008zoa.3 uc008zoa.4 Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin. Interacts with SLAIN2. Interacts with TUBA1B, MAPRE1 and MAPRE3. Interacts (via zinc finger) with DCTN1 (By similarity). Binds preferentially to tyrosinated microtubules, and only marginally to detyrosinated microtubules (PubMed:16954346). Cytoplasm Cytoplasm, cytoskeleton Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, ruffle Note=Localizes to microtubule plus ends. Localizes preferentially to the ends of tyrosinated microtubules (PubMed:16954346). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q922J3-1; Sequence=Displayed; Name=2; IsoId=Q922J3-2; Sequence=VSP_019425; Expressed in the testes (at protein level). Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction with tubulin. Phosphorylated (PubMed:26972003). Phosphorylation induces conformational changes by increasing the affinity of the N-terminus for C-terminus, resulting in inhibition of its function thus decreasing its binding to microtubules and DCTN1. Exhibits a folded, autoinhibited conformation when phosphorylated and an open conformation when dephosphorylated with increased binding affinity to microtubules and DCTN1. Phosphorylation regulates its recruitment to tyrosinated microtubules and the recruitment of vesicular cargo to microtubules in neurons. Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules (By similarity). Sequence=BAD90357.1; Type=Erroneous initiation; Evidence=; microtubule bundle formation ruffle protein binding nuclear envelope cytoplasm centrosome cytoskeleton microtubule microtubule binding zinc ion binding microtubule cytoskeleton tubulin binding membrane cytoplasmic vesicle membrane positive regulation of microtubule polymerization cytoplasmic vesicle microtubule plus-end identical protein binding cell projection macropinosome protein transport into plasma membrane raft metal ion binding microtubule plus-end binding cytoplasmic microtubule uc008zoa.1 uc008zoa.2 uc008zoa.3 uc008zoa.4 
ENSMUST00000111568.5 Or5w18 ENSMUST00000111568.5 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR37) ENSMUST00000111568.1 ENSMUST00000111568.2 ENSMUST00000111568.3 ENSMUST00000111568.4 Olfr1143 Or5w18 Q7TR37 Q7TR37_MOUSE uc289xwm.1 uc289xwm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xwm.1 uc289xwm.2 
ENSMUST00000111569.9 Caprin2 ENSMUST00000111569.9 caprin family member 2, transcript variant 1 (from RefSeq NM_181541.5) C1qdc1 CAPR2_MOUSE Caprin2 ENSMUST00000111569.1 ENSMUST00000111569.2 ENSMUST00000111569.3 ENSMUST00000111569.4 ENSMUST00000111569.5 ENSMUST00000111569.6 ENSMUST00000111569.7 ENSMUST00000111569.8 Kiaa1873 NM_181541 Q05A80 Q58E31 Q6ZPG7 Rng140 uc009etp.1 uc009etp.2 uc009etp.3 This gene encodes a member of the caprin family. The encoded protein may function as an RNA-binding protein that induces the formation of RNA granules and plays an important role in brain function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (By similarity). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (By similarity). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (PubMed:20516077). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (By similarity). May be involved in apoptosis (By similarity). Homotrimer; via C1q domain. Found in a complex with LRP6, CCNY and CDK14 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus. Interacts with LRP5. Interacts with LRP6. Cytoplasm Cell membrane; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q05A80-1; Sequence=Displayed; Name=2 ; IsoId=Q05A80-2; Sequence=VSP_052540; Specifically expressed in brain (at protein level). Detected at 17.5 dpc in brain (at protein level). The C1q domain is essential for the function in Wnt signaling. Belongs to the caprin family. Sequence=BAC98270.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA binding receptor binding nucleus cytoplasm mitochondrion centrosome cytosol plasma membrane membrane negative regulation of translation cell differentiation negative regulation of cell growth positive regulation of protein binding positive regulation of peptidyl-serine phosphorylation regulation of growth receptor complex positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of dendrite morphogenesis positive regulation of dendritic spine morphogenesis positive regulation of canonical Wnt signaling pathway uc009etp.1 uc009etp.2 uc009etp.3 
ENSMUST00000111572.8 Pramel6 ENSMUST00000111572.8 PRAME like 6, transcript variant 2 (from RefSeq NM_178249.3) ENSMUST00000111572.1 ENSMUST00000111572.2 ENSMUST00000111572.3 ENSMUST00000111572.4 ENSMUST00000111572.5 ENSMUST00000111572.6 ENSMUST00000111572.7 NM_178249 Pramel6 Q810Y9 Q810Y9_MOUSE uc008kob.1 uc008kob.2 uc008kob.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008kob.1 uc008kob.2 uc008kob.3 
ENSMUST00000111574.3 Or8h8 ENSMUST00000111574.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AVB0) A2AVB0 A2AVB0_MOUSE ENSMUST00000111574.1 ENSMUST00000111574.2 Olfr1098 Or8h8 uc289xth.1 uc289xth.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xth.1 uc289xth.2 
ENSMUST00000111584.9 Afap1l2 ENSMUST00000111584.9 actin filament associated protein 1-like 2, transcript variant 1 (from RefSeq NM_001177796.1) AF1L2_MOUSE ENSMUST00000111584.1 ENSMUST00000111584.2 ENSMUST00000111584.3 ENSMUST00000111584.4 ENSMUST00000111584.5 ENSMUST00000111584.6 ENSMUST00000111584.7 ENSMUST00000111584.8 Kiaa1914 NM_001177796 Q5DTU0 Q8BID1 Q8K2G0 uc008hzm.1 uc008hzm.2 uc008hzm.3 uc008hzm.4 May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation (By similarity). Interacts with SRC. Interacts with LCK when tyrosine phosphorylated (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5DTU0-1; Sequence=Displayed; Name=2; IsoId=Q5DTU0-2; Sequence=VSP_014257; Tyrosine phosphorylated (by SRC). Sequence=AAH31515.1; Type=Erroneous initiation; Evidence=; Sequence=BAC39879.1; Type=Frameshift; Evidence=; Sequence=BAD90264.1; Type=Erroneous initiation; Evidence=; protein binding cytoplasm cytosol plasma membrane inflammatory response regulation of mitotic cell cycle regulation of signal transduction SH3 domain binding protein tyrosine kinase activator activity regulation of interleukin-6 production positive regulation of interleukin-8 production signaling adaptor activity SH2 domain binding positive regulation of epidermal growth factor receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of protein tyrosine kinase activity uc008hzm.1 uc008hzm.2 uc008hzm.3 uc008hzm.4 
ENSMUST00000111587.10 Diablo ENSMUST00000111587.10 diablo, IAP-binding mitochondrial protein (from RefSeq NM_023232.3) DBLOH_MOUSE Diablo ENSMUST00000111587.1 ENSMUST00000111587.2 ENSMUST00000111587.3 ENSMUST00000111587.4 ENSMUST00000111587.5 ENSMUST00000111587.6 ENSMUST00000111587.7 ENSMUST00000111587.8 ENSMUST00000111587.9 NM_023232 Q542V8 Q9CZD1 Q9DCD3 Q9JIQ3 Smac uc008znx.1 uc008znx.2 uc008znx.3 Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity). Homodimer (By similarity). Interacts with BIRC2/c-IAP1 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with BIRC7/livin (By similarity). Interacts with the monomeric and dimeric form of BIRC5/survivin (By similarity). Interacts with XIAP/BIRC4 (via BIR3 domain) (By similarity). Interacts with BEX3 (PubMed:15178455). Interacts with AREL1 (via HECT domain); in the cytoplasm following induction of apoptosis (PubMed:23479728). PRO_0000021073; P98170: XIAP; Xeno; NbExp=3; IntAct=EBI-25438230, EBI-517127; Mitochondrion Cytoplasm, cytosol Note=Released into the cytosol in a PARL-dependent manner when cells undergo apoptosis. Highest expression found in heart, liver, kidney and testis. The mature N-terminus mediates interaction with XIAP/BIRC4. Ubiquitinated by BIRC7/livin. The precursor form is proteolytically cleaved by mitochondrial processing peptidase MPP to remove the transit peptide and produce an intermediate form. This is then processed by PARL to produce the mature cleaved form which is released from mitochondria into the cytosol in apoptotic cells. cytoplasm mitochondrion mitochondrial intermembrane space apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process intrinsic apoptotic signaling pathway in response to oxidative stress activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c cytoplasmic side of plasma membrane CD40 receptor complex positive regulation of apoptotic process neuron apoptotic process intrinsic apoptotic signaling pathway uc008znx.1 uc008znx.2 uc008znx.3 
ENSMUST00000111588.9 4933413L06Rik ENSMUST00000111588.9 RIKEN cDNA 4933413L06 gene (from RefSeq NR_045508.1) ENSMUST00000111588.1 ENSMUST00000111588.2 ENSMUST00000111588.3 ENSMUST00000111588.4 ENSMUST00000111588.5 ENSMUST00000111588.6 ENSMUST00000111588.7 ENSMUST00000111588.8 NR_045508 uc007ryp.1 uc007ryp.2 uc007ryp.1 uc007ryp.2 
ENSMUST00000111589.3 Or5m3 ENSMUST00000111589.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2ATE5) A2ATE3 A2ATE5 A2ATE5_MOUSE ENSMUST00000111589.1 ENSMUST00000111589.2 Olfr1032 Or5m3 uc289xqf.1 uc289xqf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xqf.1 uc289xqf.2 
ENSMUST00000111594.3 Pigc ENSMUST00000111594.3 phosphatidylinositol glycan anchor biosynthesis, class C, transcript variant 1 (from RefSeq NM_026078.2) ENSMUST00000111594.1 ENSMUST00000111594.2 NM_026078 PIGC_MOUSE Pigc Q3U7H3 Q9CXR4 uc007dfy.1 uc007dfy.2 uc007dfy.3 Part of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Component of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts with PIGQ. Interacts with the heterodimer PIGA:PIGH. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the PIGC family. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups phosphatidylinositol N-acetylglucosaminyltransferase activity uc007dfy.1 uc007dfy.2 uc007dfy.3 
ENSMUST00000111605.9 Tnks1bp1 ENSMUST00000111605.9 tankyrase 1 binding protein 1 (from RefSeq NM_001081260.2) A2BH84 ENSMUST00000111605.1 ENSMUST00000111605.2 ENSMUST00000111605.3 ENSMUST00000111605.4 ENSMUST00000111605.5 ENSMUST00000111605.6 ENSMUST00000111605.7 ENSMUST00000111605.8 Kiaa1741 NM_001081260 P58871 Q6ZPI8 TB182_MOUSE Tab182 uc012byp.1 uc012byp.2 Binds to the ANK repeat domain of TNKS1 and TNKS2. Nucleus Cytoplasm, cytoskeleton Chromosome Note=Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin. ADP-ribosylated by TNKS1. Sequence=CAM22340.1; Type=Erroneous gene model prediction; Evidence=; nucleus chromosome nuclear heterochromatin cytoplasm cytoskeleton cell-cell adherens junction double-strand break repair positive regulation of peptidyl-threonine phosphorylation enzyme binding CCR4-NOT complex positive regulation of protein autophosphorylation positive regulation of peptidyl-serine phosphorylation macromolecular complex binding cellular response to ionizing radiation ankyrin repeat binding uc012byp.1 uc012byp.2 
ENSMUST00000111606.8 Tdrd1 ENSMUST00000111606.8 tudor domain containing 1, transcript variant 1 (from RefSeq NM_001002238.2) A2VDG6 ENSMUST00000111606.1 ENSMUST00000111606.2 ENSMUST00000111606.3 ENSMUST00000111606.4 ENSMUST00000111606.5 ENSMUST00000111606.6 ENSMUST00000111606.7 NM_001002238 Q6F3G0 Q8CDN7 Q8K1G3 Q99MV1 TDRD1_MOUSE uc008hzi.1 uc008hzi.2 Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins. Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Interacts with MAEL. Interacts with PIWIL1, PIWIL2 and PIWIL4 (when methylated on arginine residues). Interacts with TDRD12. Q99MV1; Q8CDG1: Piwil2; NbExp=6; IntAct=EBI-8573364, EBI-8573412; Cytoplasm Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis (PubMed:20439430). DDX4 is required for meiotic nuage localization. Also present in chromatoid body. Testis and ovary specific. Present in germ-line cells and is most abundant in fetal prospermatogonia and postnatal primary spermatocytes (at protein level). Tudor domains 2 and 3 have higher affinity for arginine- methylated peptides, tudor domain 1 is a poor binder due to an impaired aromatic cage. Male sterility because of postnatal spermatogenic defects due to demethylation and subsequent derepression of transposable elements. Piwi-associated small RNA profiles are altered, piRNPs accepting the entry of abundant cellular transcripts into the piRNA pathway and accumulating piRNAs with a profile that is drastically different from wild-type. Piwi proteins are delocalized from the nucleus to the cytoplasm. Belongs to the TDRD1 family. Sequence=AAI29955.1; Type=Erroneous initiation; Evidence=; Sequence=AAI29956.1; Type=Erroneous initiation; Evidence=; Sequence=AAK31970.1; Type=Erroneous initiation; Evidence=; Sequence=BAD27578.1; Type=Erroneous initiation; Evidence=; protein binding cytoplasm cytosol multicellular organism development germ cell development spermatogenesis cell differentiation gene silencing by RNA chromatoid body piRNA metabolic process DNA methylation involved in gamete generation P granule metal ion binding meiotic cell cycle pi-body ribonucleoprotein complex uc008hzi.1 uc008hzi.2 
ENSMUST00000111608.8 Ankrd45 ENSMUST00000111608.8 ankyrin repeat domain 45, transcript variant 2 (from RefSeq NM_001368766.1) ANR45_MOUSE ENSMUST00000111608.1 ENSMUST00000111608.2 ENSMUST00000111608.3 ENSMUST00000111608.4 ENSMUST00000111608.5 ENSMUST00000111608.6 ENSMUST00000111608.7 NM_001368766 Q810N6 uc287ndj.1 uc287ndj.2 May play a role during cell division. Cytoplasm Midbody, Midbody ring Cleavage furrow Note=Distribution is highly dynamic during mitosis. Not detected during interphase, localized to cytoplasm during metaphase, to cleavage furrow during anaphase and telophase, and to midbody ring during cytokinesis. molecular_function cellular_component biological_process uc287ndj.1 uc287ndj.2 
ENSMUST00000111611.8 Klhl20 ENSMUST00000111611.8 kelch-like 20 (from RefSeq NM_001039482.1) ENSMUST00000111611.1 ENSMUST00000111611.2 ENSMUST00000111611.3 ENSMUST00000111611.4 ENSMUST00000111611.5 ENSMUST00000111611.6 ENSMUST00000111611.7 KLH20_MOUSE Kiaa4210 Kleip NM_001039482 Q5DTH3 Q8BWA2 Q8VCK5 uc007dff.1 uc007dff.2 uc007dff.3 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (By similarity). Protein modification; protein ubiquitination. Component of the BCR(KLHL20) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL20 and RBX1. Interacts with PDZ- RhoGEF/ARHGEF11, DAPK1, PML and CORO7. Interacts with F-actin. Interacts with IFN-gamma (IFNG) (By similarity). Interacts (via kelch repeats) with IVNS1ABP (via kelch repeats); this interaction blocks the assembly of CUL3-KLHL20 complex (By similarity). Cytoplasm, perinuclear region Nucleus Golgi apparatus, trans-Golgi network Cell projection, axon Cell projection, dendrite Note=Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN-gamma treatment, it is relocalized and sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination (By similarity). Approximately 50% of mice die until day 28 of postnatal development (P28). Mice that survive beyond P28 are indistinguishable at birth, but show a progressive corneal dystrophy, associated with an epithelial hyperplasia and an altered corneal epithelial cell differentiation. Sequence=BAD90319.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; actin binding ubiquitin-protein transferase activity nucleus cytoplasm Golgi apparatus trans-Golgi network cytosol Golgi to endosome transport protein transport protein ubiquitination PML body interferon-gamma binding axon dendrite Cul3-RING ubiquitin ligase complex cell projection negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process perinuclear region of cytoplasm protein K33-linked ubiquitination uc007dff.1 uc007dff.2 uc007dff.3 
ENSMUST00000111620.10 Cenpl ENSMUST00000111620.10 centromere protein L, transcript variant 1 (from RefSeq NM_001159930.2) Cenpl ENSMUST00000111620.1 ENSMUST00000111620.2 ENSMUST00000111620.3 ENSMUST00000111620.4 ENSMUST00000111620.5 ENSMUST00000111620.6 ENSMUST00000111620.7 ENSMUST00000111620.8 ENSMUST00000111620.9 NM_001159930 Q14A61 Q14A61_MOUSE uc007dfc.1 uc007dfc.2 uc007dfc.3 uc007dfc.4 uc007dfc.5 Nucleus Belongs to the CENP-L/IML3 family. uc007dfc.1 uc007dfc.2 uc007dfc.3 uc007dfc.4 uc007dfc.5 
ENSMUST00000111622.2 1700034J05Rik ENSMUST00000111622.2 RIKEN cDNA 1700034J05 gene, transcript variant 2 (from RefSeq NM_001164236.1) CL071_MOUSE ENSMUST00000111622.1 NM_001164236 Q80W69 Q8C629 Q8CDR6 Q9D9Q1 uc012evt.1 uc012evt.2 uc012evt.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80W69-1; Sequence=Displayed; Name=2; IsoId=Q80W69-2; Sequence=VSP_034616; molecular_function cellular_component biological_process uc012evt.1 uc012evt.2 uc012evt.3 
ENSMUST00000111635.4 Xirp1 ENSMUST00000111635.4 xin actin-binding repeat containing 1, transcript variant 1 (from RefSeq NM_011724.5) E9QQ93 E9QQ93_MOUSE ENSMUST00000111635.1 ENSMUST00000111635.2 ENSMUST00000111635.3 NM_011724 Xirp1 uc009sbw.1 uc009sbw.2 uc009sbw.3 Protects actin filaments from depolymerization. Xin repeats bind F-actin. Belongs to the Xin family. actin binding actin cytoskeleton organization cell junction uc009sbw.1 uc009sbw.2 uc009sbw.3 
ENSMUST00000111639.8 Bmal2 ENSMUST00000111639.8 Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post- translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. (from UniProt Q2VPD4) AY005163 Arntl2 BMAL2_MOUSE ENSMUST00000111639.1 ENSMUST00000111639.2 ENSMUST00000111639.3 ENSMUST00000111639.4 ENSMUST00000111639.5 ENSMUST00000111639.6 ENSMUST00000111639.7 Q2VPD4 Q32MV7 Q91XJ5 Q91XJ6 uc009esj.1 uc009esj.2 uc009esj.3 uc009esj.4 Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post- translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with CLOCK to form the BMAL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription activator. Interacts with NPAS2 and HIF1A (By similarity). Interacts with PER2. Q2VPD4; P97784: Cry1; NbExp=3; IntAct=EBI-9696862, EBI-1266607; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=BMAL2a; IsoId=Q2VPD4-1; Sequence=Displayed; Name=2; Synonyms=BMAL2b; IsoId=Q2VPD4-2; Sequence=VSP_022586, VSP_022587; Expressed in the suprachiasmatic nucleus (SCN). Constitutively expressed in the SCN. Little change throughout day under dark/light cycle. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex nucleolus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter circadian rhythm positive regulation of circadian rhythm positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity rhythmic process E-box binding uc009esj.1 uc009esj.2 uc009esj.3 uc009esj.4 
ENSMUST00000111665.8 Tmx2 ENSMUST00000111665.8 thioredoxin-related transmembrane protein 2, transcript variant 1 (from RefSeq NM_025868.4) ENSMUST00000111665.1 ENSMUST00000111665.2 ENSMUST00000111665.3 ENSMUST00000111665.4 ENSMUST00000111665.5 ENSMUST00000111665.6 ENSMUST00000111665.7 NM_025868 Q8BW13 Q9D710 TMX2_MOUSE Txndc14 uc008kix.1 uc008kix.2 uc008kix.3 uc008kix.4 Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain. Monomer (By similarity). Homodimer; disulfide-linked (By similarity). Occurs in both reduced and oxidized monomeric form (By similarity). Oxidative conditions increase homodimerization (By similarity). Interacts with CANX (By similarity). Interacts with ATP2A2 (By similarity). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Mitochondrion membrane ; Single-pass type I membrane protein Note=Localizes to endoplasmic reticulum mitochondria-associated membrane (MAMs) that connect the endoplasmic reticulum and the mitochondria. The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity. The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins. molecular_function cellular_component cell biological_process membrane integral component of membrane cell redox homeostasis uc008kix.1 uc008kix.2 uc008kix.3 uc008kix.4 
ENSMUST00000111668.8 Camkk2 ENSMUST00000111668.8 calcium/calmodulin-dependent protein kinase kinase 2, beta, transcript variant 1 (from RefSeq NM_001199676.1) ENSMUST00000111668.1 ENSMUST00000111668.2 ENSMUST00000111668.3 ENSMUST00000111668.4 ENSMUST00000111668.5 ENSMUST00000111668.6 ENSMUST00000111668.7 KKCC2_MOUSE Kiaa0787 NM_001199676 Q80TS0 Q8BXM8 Q8C078 Q8C0G3 Q8CH42 Q8QZT7 uc008zlz.1 uc008zlz.2 uc008zlz.3 uc008zlz.4 uc008zlz.5 Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK4 and CAMK1D (By similarity). Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching (By similarity). May be involved in hippocampal activation of CREB1. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17; Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca(2+)/calmodulin. In part, activity is independent on Ca(2+)/calmodulin (By similarity). Interacts with calmodulin. Q8C078; P49593: PPM1F; Xeno; NbExp=2; IntAct=EBI-937199, EBI-719945; Nucleus Cytoplasm Cell projection, neuron projection Note=Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8C078-1; Sequence=Displayed; Name=2; IsoId=Q8C078-2; Sequence=VSP_012155; Name=3; IsoId=Q8C078-3; Sequence=VSP_012151, VSP_012152, VSP_012154; Name=4; IsoId=Q8C078-4; Sequence=VSP_012150, VSP_012153; Name=5; IsoId=Q8C078-5; Sequence=VSP_012156; Expressed in all tissues tested. A differential expression pattern compared to CAMKK1 is observed in the brain. The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates. Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation. Mice are unable to form spatial long-term memory. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity calcium ion binding protein binding calmodulin binding ATP binding nucleus cytoplasm cytosol protein phosphorylation kinase activity phosphorylation transferase activity activation of protein kinase activity cell projection protein autophosphorylation CAMKK-AMPK signaling cascade uc008zlz.1 uc008zlz.2 uc008zlz.3 uc008zlz.4 uc008zlz.5 
ENSMUST00000111704.8 Rassf8 ENSMUST00000111704.8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 (from RefSeq NM_027760.3) ENSMUST00000111704.1 ENSMUST00000111704.2 ENSMUST00000111704.3 ENSMUST00000111704.4 ENSMUST00000111704.5 ENSMUST00000111704.6 ENSMUST00000111704.7 NM_027760 Q149Q5 Q8CCW4 Q8CJ96 Q9CU91 RASF8_MOUSE uc009ers.1 uc009ers.2 uc009ers.3 signal transduction adherens junction maintenance uc009ers.1 uc009ers.2 uc009ers.3 
ENSMUST00000111706.8 Lmntd1 ENSMUST00000111706.8 lamin tail domain containing 1, transcript variant 6 (from RefSeq NM_001417812.1) E9Q8Y6 E9Q8Y6_MOUSE ENSMUST00000111706.1 ENSMUST00000111706.2 ENSMUST00000111706.3 ENSMUST00000111706.4 ENSMUST00000111706.5 ENSMUST00000111706.6 ENSMUST00000111706.7 Ifltd1 Lmntd1 NM_001417812 uc009ero.1 uc009ero.2 uc009ero.3 uc009ero.1 uc009ero.2 uc009ero.3 
ENSMUST00000111718.8 Tfpi ENSMUST00000111718.8 Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (By similarity). (from UniProt O54819) AK028356 ENSMUST00000111718.1 ENSMUST00000111718.2 ENSMUST00000111718.3 ENSMUST00000111718.4 ENSMUST00000111718.5 ENSMUST00000111718.6 ENSMUST00000111718.7 O54819 Q9Z2U8 TFPI1_MOUSE uc289xko.1 uc289xko.2 Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (By similarity). Secreted. Event=Alternative splicing; Named isoforms=2; Name=Alpha; Synonyms=TFPIalpha; IsoId=O54819-1; Sequence=Displayed; Name=Beta; Synonyms=TFPIbeta; IsoId=O54819-2; Sequence=VSP_003032, VSP_003033; Isoform alpha is expressed in heart and spleen; isoform beta in heart and lung. This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa (By similarity). serine-type endopeptidase inhibitor activity extracellular region extracellular space caveola blood coagulation hemostasis cell surface negative regulation of peptidase activity negative regulation of endopeptidase activity negative regulation of blood coagulation peptidase inhibitor activity cellular response to steroid hormone stimulus uc289xko.1 uc289xko.2 
ENSMUST00000111735.10 Tmem260 ENSMUST00000111735.10 transmembrane protein 260, transcript variant 1 (from RefSeq NM_172600.4) ENSMUST00000111735.1 ENSMUST00000111735.2 ENSMUST00000111735.3 ENSMUST00000111735.4 ENSMUST00000111735.5 ENSMUST00000111735.6 ENSMUST00000111735.7 ENSMUST00000111735.8 ENSMUST00000111735.9 NM_172600 Q6GT69 Q80SZ4 Q8BMD6 Q8BMG3 Q8BW28 Q8BYU4 TM260_MOUSE Tmem260 uc007tjo.1 uc007tjo.2 uc007tjo.3 uc007tjo.4 uc007tjo.5 O-mannosyl-transferase that transfers mannosyl residues to the hydroxyl group of serine or threonine residues of proteins. Specifically glycosylates the IPT/TIG domain of target proteins, such as MET and MST1R/RON. TMEM260-mediated O-mannosylated residues are composed of single mannose glycans that are not elongated or modified. Reaction=a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3- O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+); Xref=Rhea:RHEA:17377, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:13546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:137321; EC=2.4.1.109; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17378; Evidence=; Reaction=a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+); Xref=Rhea:RHEA:53396, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13547, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:137323; EC=2.4.1.109; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53397; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BMD6-1; Sequence=Displayed; Name=2; IsoId=Q8BMD6-2; Sequence=VSP_008622; Receptor maturation defects and abnormal epithelial morphogenesis. Belongs to the glycosyltransferase 117 (GT117) family. Sequence=AAH59217.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC28033.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC35803.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc007tjo.1 uc007tjo.2 uc007tjo.3 uc007tjo.4 uc007tjo.5 
ENSMUST00000111737.3 Mxi1 ENSMUST00000111737.3 MAX interactor 1, dimerization protein, transcript variant 1 (from RefSeq NM_010847.4) ENSMUST00000111737.1 ENSMUST00000111737.2 Mxi1 NM_010847 Q3USD3 Q3USD3_MOUSE uc008hwr.1 uc008hwr.2 uc008hwr.3 This gene encodes a protein containing a helix-loop-helix domain characteristic of transcription factors, which allows heterodimerization and sequence-specific DNA binding. The encoded protein is related to a family of Myc/Max/Mad proteins that are involved in the regulation of several cellular processes. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate Myc function. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Nucleus protein dimerization activity uc008hwr.1 uc008hwr.2 uc008hwr.3 
ENSMUST00000111738.8 Tctn1 ENSMUST00000111738.8 tectonic family member 1, transcript variant 1 (from RefSeq NM_001039153.3) ENSMUST00000111738.1 ENSMUST00000111738.2 ENSMUST00000111738.3 ENSMUST00000111738.4 ENSMUST00000111738.5 ENSMUST00000111738.6 ENSMUST00000111738.7 NM_001039153 Q3UMP0 Q8BUE2 Q8BZ64 TECT1_MOUSE Tect1 uc033ilv.1 uc033ilv.2 uc033ilv.3 uc033ilv.4 Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23. Part of the tectonic-like complex (also named B9 complex). Cytoplasm, cytoskeleton, cilium basal body. Secreted. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Despite the presence of a signal sequence, the full-length protein might not be secreted (PubMed:16357211). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZ64-1; Sequence=Displayed; Name=2; IsoId=Q8BZ64-2; Sequence=VSP_017764, VSP_017765; During embryonic development, it is expressed in regions that participate in Hedgehog signaling. First expressed during gastrulation stages in the ventral node. At 9.5 dpc, expressed in the gut endoderm, limb buds, notochord, somites, neural tube and floorplate. Null animals show disruption of nodal flow, laterality defects, and neural tube dorsalization. Basal bodies dock to the cellular plasma membrane, but fail to extend axonemes. However, cilia are present in the notochord, early gut epithelium, and mesenchymal cells surrounding the neural tube and in the limb bud. Null embryos develop an extra preaxial digit on 1 or both hindlimbs. Although sonic hedgehog (Shh) expression is normal, downstream signaling is disturbed, suggesting that Tctn1 is required for cilium- dependent Shh signal transduction. Was named 'Tectonic' after the Greek word for builder. Belongs to the tectonic family. Sequence=BAE26058.1; Type=Frameshift; Evidence=; in utero embryonic development neural tube formation protein binding extracellular region extracellular space cytoplasm cytoskeleton multicellular organism development regulation of smoothened signaling pathway membrane somatic motor neuron differentiation telencephalon development dorsal/ventral neural tube patterning central nervous system interneuron axonogenesis cell projection organization ciliary transition zone MKS complex cell projection cilium assembly protein localization to ciliary transition zone uc033ilv.1 uc033ilv.2 uc033ilv.3 uc033ilv.4 
ENSMUST00000111741.10 Add3 ENSMUST00000111741.10 adducin 3, transcript variant 4 (from RefSeq NM_001164101.3) ADDG_MOUSE Addl ENSMUST00000111741.1 ENSMUST00000111741.2 ENSMUST00000111741.3 ENSMUST00000111741.4 ENSMUST00000111741.5 ENSMUST00000111741.6 ENSMUST00000111741.7 ENSMUST00000111741.8 ENSMUST00000111741.9 NM_001164101 Q8JZT6 Q9D2M5 Q9QYB5 Q9QYB6 uc008hwi.1 uc008hwi.2 uc008hwi.3 uc008hwi.4 uc008hwi.5 uc008hwi.6 Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin (By similarity). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G- actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E- cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (PubMed:33992672). Heterodimer of an alpha and a gamma subunit. Cytoplasm, cytoskeleton Cell membrane ; Peripheral membrane protein; Cytoplasmic side. Cytoplasm Note=Full- length protein and the cleavage fragment 358-706 localize mainly to the cytoplasm, while cleavage fragment 1-357 translocates from the cytoplasm to the nucleus. Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=2; Synonyms=Long; IsoId=Q9QYB5-1; Sequence=Displayed; Name=1; Synonyms=Short; IsoId=Q9QYB5-2; Sequence=VSP_000189; Cleavage fragment 1-357 is expressed in the brain and the expression increases with age (at protein level). The fragment is expressed in the cortex, hippocampal CA1 region and hippocampal dentate gyrus in tau P301S transgenic mice, a mouse model for Alzheimer disease (AD) (at protein level). The fragment is only weakly expressed in non-transgenic mouse brain sections (at protein level). Comprised of three regions: a N-terminal protease-resistant globular head region, a short connecting subdomain, and a protease- sensitive tail region. Sumoylated. Proteolytically cleaved by asparagine endopeptidase (AEP) into 2 fragments. Overexpression of the 1-357 fragment induces neuronal apoptosis, and overexpression of either 1-357 or 358-706 fragment increases the degeneration of dendritic spines. Overexpression of the 1-357 fragment impairs neurite outgrowth by downregulating the expression of Rac2, and induces synaptic dysfunction and cognitive impairments in tau P301S transgenic mice, a mouse model for Alzheimer disease (AD). Belongs to the aldolase class II family. Adducin subfamily. condensed nuclear chromosome actin binding protein kinase C binding structural constituent of cytoskeleton calmodulin binding nucleoplasm cytoplasm cytoskeleton plasma membrane brush border cell-cell junction cell cortex postsynaptic density membrane spectrin binding response to drug plasma membrane raft positive regulation of vasoconstriction actin filament binding barbed-end actin filament capping actin filament bundle assembly uc008hwi.1 uc008hwi.2 uc008hwi.3 uc008hwi.4 uc008hwi.5 uc008hwi.6 
ENSMUST00000111742.8 Bcat1 ENSMUST00000111742.8 branched chain aminotransferase 1, cytosolic, transcript variant 2 (from RefSeq NM_007532.5) Bcat1 ENSMUST00000111742.1 ENSMUST00000111742.2 ENSMUST00000111742.3 ENSMUST00000111742.4 ENSMUST00000111742.5 ENSMUST00000111742.6 ENSMUST00000111742.7 NM_007532 Q3TJN1 Q3TJN1_MOUSE uc009eqt.1 uc009eqt.2 uc009eqt.3 uc009eqt.4 Reaction=2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate; Xref=Rhea:RHEA:24801, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:35146, ChEBI:CHEBI:58045; EC=2.6.1.42; Evidence= Reaction=2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L- glutamate; Xref=Rhea:RHEA:18321, ChEBI:CHEBI:16810, ChEBI:CHEBI:17865, ChEBI:CHEBI:29985, ChEBI:CHEBI:57427; EC=2.6.1.42; Evidence= Reaction=2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L- glutamate; Xref=Rhea:RHEA:24813, ChEBI:CHEBI:11851, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57762; EC=2.6.1.42; Evidence= Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence= Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. catalytic activity branched-chain-amino-acid transaminase activity transaminase activity cellular amino acid biosynthetic process branched-chain amino acid metabolic process branched-chain amino acid biosynthetic process transferase activity L-leucine transaminase activity L-valine transaminase activity L-isoleucine transaminase activity uc009eqt.1 uc009eqt.2 uc009eqt.3 uc009eqt.4 
ENSMUST00000111751.8 Myl2 ENSMUST00000111751.8 myosin, light polypeptide 2, regulatory, cardiac, slow, transcript variant 2 (from RefSeq NM_001384326.1) ENSMUST00000111751.1 ENSMUST00000111751.2 ENSMUST00000111751.3 ENSMUST00000111751.4 ENSMUST00000111751.5 ENSMUST00000111751.6 ENSMUST00000111751.7 MLRV_MOUSE Myl2 Mylpc NM_001384326 P51667 Q6P8P4 Q9QVP3 uc290zih.1 uc290zih.2 Contractile protein that plays a role in heart development and function (PubMed:10409661). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity) (PubMed:22426213, PubMed:16908724, PubMed:10409661). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (PubMed:9422794). Myosin is a hexamer of 2 heavy chains and 4 light chains (By similarity). Interacts with MYOC (By similarity). Cytoplasm, myofibril, sarcomere, A band Abundantly expressed in both cardiac and slow skeletal muscle (PubMed:1379240). In the adult heart, the phosphorylated form is highly expressed in epicardium and weakly in endocardium (PubMed:22426213). At 8 dpc highly expressed in the ventricular portion of the heart tube, with no detectable expression in the atrial or sinus venosus regions; also expressed in the proximal outflow tract of the heart tube at minimally detectable levels. At 9-10 dpc expression is well established in the proximal outflow tract region adjacent to the ventricular segment. At 11 dpc, expression becomes restricted to the ventricular region. N-terminus is methylated by METTL11A/NTM1. Phosphorylated by MYLK3 and MYLK2; promotes cardiac muscle contraction and function. Dephosphorylated by PPP1CB complexed to PPP1R12B (By similarity). The phosphorylated form in adult is expressed as gradients across the heart from endocardium (low phosphorylation) to epicardium (high phosphorylation); regulates cardiac torsion and workload distribution (PubMed:22426213). Myl2 homozygous die at 12.5 dpc, which is associated with ultrastructural defects in ventricular sarcomere assembly, that included disruptions and disorganization of the normal parallel alignment of the thick and thin filaments, narrower fiber widths and larger distances between Z disks and misalignment of Z-band between sarcomeres. This chain binds calcium. regulation of the force of heart contraction heart morphogenesis actin monomer binding calcium ion binding cytoplasm cytoskeleton heart development post-embryonic development actin cytoskeleton myosin complex myofibril negative regulation of cell growth A band muscle cell fate specification contractile fiber metal ion binding muscle fiber development cardiac myofibril assembly ventricular cardiac muscle tissue morphogenesis heart contraction cardiac muscle contraction cardiac myofibril positive regulation of the force of heart contraction uc290zih.1 uc290zih.2 
ENSMUST00000111752.10 Cux2 ENSMUST00000111752.10 cut-like homeobox 2, transcript variant 2 (from RefSeq NM_001312908.1) CUX2_MOUSE Cutl2 ENSMUST00000111752.1 ENSMUST00000111752.2 ENSMUST00000111752.3 ENSMUST00000111752.4 ENSMUST00000111752.5 ENSMUST00000111752.6 ENSMUST00000111752.7 ENSMUST00000111752.8 ENSMUST00000111752.9 NM_001312908 P70298 Q6P1E6 uc057bvk.1 uc057bvk.2 uc057bvk.3 This gene is a member of the Cut family of transcription factors that have multiple DNA binding domains and regulate cell proliferation and differentiation. This gene is primarily expressed in nervous tissues where it controls the proliferation of neuronal precursors, and may play a role in organogenesis earlier during embryonic development. Mice lacking the encoded protein exhibit smaller spinal cords with deficits in neural progenitor development as well as in neuroblast and interneuron differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. Transcription factor involved in the control of neuronal proliferation and differentiation in the brain (PubMed:18033766, PubMed:20510857). Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III (PubMed:20510857). Binds to DNA in a sequence-specific manner. Nucleus. Restricted to neural tissues. Expressed exclusively in the central and peripheral nervous systems. Knockout mice show moderately but consistently bigger brains than wild-type animals. Cell density and thickness of upper cortical layers (II-IV) are increased, while there are no differences in neuronal density in layers V and VI (PubMed:18033766). Neurons in layer II-III show simpler morphologies, with a significant decrease in the dendritic length and the number of branches, as well as a severe reduction of dendritic spines density associated with synaptic defects. The working memory is impaired (PubMed:20510857). Belongs to the CUT homeobox family. negative regulation of transcription from RNA polymerase II promoter Golgi membrane RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding nucleus regulation of transcription, DNA-templated short-term memory positive regulation of gene expression sequence-specific DNA binding negative regulation of transcription, DNA-templated Golgi vesicle transport positive regulation of dendrite morphogenesis cognition positive regulation of synapse assembly positive regulation of dendritic spine morphogenesis cellular response to organic substance positive regulation of excitatory postsynaptic potential uc057bvk.1 uc057bvk.2 uc057bvk.3 
ENSMUST00000111757.10 Tor1aip2 ENSMUST00000111757.10 torsin A interacting protein 2, transcript variant 5 (from RefSeq NM_172843.4) ENSMUST00000111757.1 ENSMUST00000111757.2 ENSMUST00000111757.3 ENSMUST00000111757.4 ENSMUST00000111757.5 ENSMUST00000111757.6 ENSMUST00000111757.7 ENSMUST00000111757.8 ENSMUST00000111757.9 Ifrg15 Lull1 NM_172843 Q6NY10 Q8BJP0 Q8BYU6 TOIP2_MOUSE uc007dbx.1 uc007dbx.2 uc007dbx.3 uc007dbx.4 uc007dbx.5 Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity (By similarity). Interacts with TOR1A and TOR1B (ATP-bound). Endoplasmic reticulum membrane ; Single-pass membrane protein Nucleus envelope Event=Alternative splicing; Named isoforms=2; Name=Tor1aip2; IsoId=Q8BYU6-1; Sequence=Displayed; Name=Ifrg15; IsoId=Q9ER81-1; Sequence=External; Expressed in the spinal cord and liver (at protein level). At 16 dpc, widely expressed with higher expression levels in non-neural cells and hippocampus. In the spinal cord, expressed as early as 12 dpc until p21, the expression levels decrease in the adulthood (at protein level). Belongs to the TOR1AIP family. ATPase activator activity protein binding nucleus nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum organization membrane integral component of membrane positive regulation of ATPase activity ATPase binding protein localization to nuclear envelope uc007dbx.1 uc007dbx.2 uc007dbx.3 uc007dbx.4 uc007dbx.5 
ENSMUST00000111764.8 Qsox1 ENSMUST00000111764.8 Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:26819240). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:26819240). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:26819240). (from UniProt Q8BND5) AK169877 ENSMUST00000111764.1 ENSMUST00000111764.2 ENSMUST00000111764.3 ENSMUST00000111764.4 ENSMUST00000111764.5 ENSMUST00000111764.6 ENSMUST00000111764.7 Q3TDY9 Q3TE19 Q3TR29 Q3UEL4 Q8BND5 Q8K041 Q9DBL6 QSOX1_MOUSE Qscn6 Sox uc011wtx.1 uc011wtx.2 uc011wtx.3 Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:26819240). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:26819240). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:26819240). Reaction=O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'; Xref=Rhea:RHEA:17357, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:16520, ChEBI:CHEBI:17412; EC=1.8.3.2; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Monomer. [Isoform 1]: Golgi apparatus membrane ; Single-pass membrane protein Secreted Note=A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor. [Isoform 2]: Secreted [Isoform 3]: Secreted [Isoform 4]: Secreted Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BND5-1; Sequence=Displayed; Name=2; IsoId=Q8BND5-2; Sequence=VSP_020495, VSP_020496; Name=3; IsoId=Q8BND5-3; Sequence=VSP_020493, VSP_020494; Name=4; IsoId=Q8BND5-4; Sequence=VSP_020491, VSP_020492; Detected in skin (at protein level) (PubMed:12354420). Expressed in the seminal vesicles and skin. N-glycosylated. O-glycosylated on Thr and Ser residues. Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. Golgi membrane protein disulfide isomerase activity extracellular region extracellular space endoplasmic reticulum Golgi apparatus membrane integral component of membrane negative regulation of macroautophagy oxidoreductase activity flavin-linked sulfhydryl oxidase activity thiol oxidase activity integral component of Golgi membrane intracellular membrane-bounded organelle intercellular bridge cell redox homeostasis oxidation-reduction process extracellular exosome FAD binding extracellular matrix assembly uc011wtx.1 uc011wtx.2 uc011wtx.3 
ENSMUST00000111768.3 Sult6b2 ENSMUST00000111768.3 sulfotransferase family 6B, member 2 (from RefSeq NM_001145390.1) B7ZWN4 B7ZWN4_MOUSE ENSMUST00000111768.1 ENSMUST00000111768.2 Gm766 NM_001145390 Sult6b2 uc012evk.1 uc012evk.2 Belongs to the sulfotransferase 1 family. molecular_function cellular_component sulfotransferase activity biological_process transferase activity uc012evk.1 uc012evk.2 
ENSMUST00000111770.2 Acad10 ENSMUST00000111770.2 acyl-Coenzyme A dehydrogenase family, member 10 (from RefSeq NM_028037.4) ACD10_MOUSE ENSMUST00000111770.1 NM_028037 Q8BWQ0 Q8K313 Q8K370 uc008zjz.1 uc008zjz.2 uc008zjz.3 Acyl-CoA dehydrogenase only active with R- and S-2-methyl- C15-CoA. Reaction=A + a 2,3-saturated acyl-CoA = a 2,3-dehydroacyl-CoA + AH2; Xref=Rhea:RHEA:48608, ChEBI:CHEBI:13193, ChEBI:CHEBI:17499, ChEBI:CHEBI:60015, ChEBI:CHEBI:65111; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Belongs to the acyl-CoA dehydrogenase family. Sequence=AAH29047.1; Type=Erroneous initiation; Evidence=; Sequence=BAC34193.1; Type=Frameshift; Evidence=; mitochondrion oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors hydrolase activity flavin adenine dinucleotide binding oxidation-reduction process uc008zjz.1 uc008zjz.2 uc008zjz.3 
ENSMUST00000111772.10 Rbms3 ENSMUST00000111772.10 RNA binding motif, single stranded interacting protein, transcript variant 2 (from RefSeq NM_001172122.1) ENSMUST00000111772.1 ENSMUST00000111772.2 ENSMUST00000111772.3 ENSMUST00000111772.4 ENSMUST00000111772.5 ENSMUST00000111772.6 ENSMUST00000111772.7 ENSMUST00000111772.8 ENSMUST00000111772.9 NM_001172122 Q2VPR0 Q8BL73 Q8BLW6 Q8BMA7 Q8BMB5 Q8BML0 Q8BMN1 Q8BWL5 RBMS3_MOUSE uc009ryx.1 uc009ryx.2 uc009ryx.3 uc009ryx.4 uc009ryx.5 uc009ryx.6 Binds poly(A) and poly(U) oligoribonucleotides. Cytoplasm Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8BWL5-1; Sequence=Displayed; Name=2; IsoId=Q8BWL5-2; Sequence=VSP_022934; Name=3; IsoId=Q8BWL5-3; Sequence=VSP_022933; Name=4; IsoId=Q8BWL5-4; Sequence=VSP_022934, VSP_022935; Name=5; IsoId=Q8BWL5-5; Sequence=VSP_022932, VSP_022933; Name=6; IsoId=Q8BWL5-6; Sequence=VSP_022935; Sequence=BAC34878.1; Type=Erroneous initiation; Evidence=; defense response to tumor cell nucleic acid binding RNA binding mRNA 3'-UTR binding cytoplasm poly(A) binding poly(U) RNA binding positive regulation of gene expression negative regulation of gene expression mRNA 3'-UTR AU-rich region binding positive regulation of translation negative regulation of canonical Wnt signaling pathway ribonucleoprotein complex uc009ryx.1 uc009ryx.2 uc009ryx.3 uc009ryx.4 uc009ryx.5 uc009ryx.6 
ENSMUST00000111785.9 Itprid2 ENSMUST00000111785.9 ITPR interacting domain containing 2 (from RefSeq NM_080558.4) A2AQD4 A5D8Z6 ENSMUST00000111785.1 ENSMUST00000111785.2 ENSMUST00000111785.3 ENSMUST00000111785.4 ENSMUST00000111785.5 ENSMUST00000111785.6 ENSMUST00000111785.7 ENSMUST00000111785.8 ITPI2_MOUSE Kiaa1927 Krap NM_080558 Q08E80 Q14BJ9 Q544I3 Q68FN1 Q75WU7 Q8CH96 Q8VEF7 Q922B9 Ssfa2 uc008kgw.1 uc008kgw.2 uc008kgw.3 uc008kgw.4 uc008kgw.5 Cytoplasm Note=Located near the plasma membrane. Associated with actin filaments. May also exist as a membrane-bound form with extracellular regions (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q922B9-1; Sequence=Displayed; Name=2; IsoId=Q922B9-2; Sequence=VSP_023869; Name=3; IsoId=Q922B9-3; Sequence=VSP_023868; Sequence=AAH08560.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH18526.3; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=AAI22520.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC29756.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; actin binding receptor binding nucleus cytoplasm cytosol plasma membrane actin filament binding uc008kgw.1 uc008kgw.2 uc008kgw.3 uc008kgw.4 uc008kgw.5 
ENSMUST00000111803.9 Recql ENSMUST00000111803.9 RecQ protein-like, transcript variant 1 (from RefSeq NM_023042.4) ENSMUST00000111803.1 ENSMUST00000111803.2 ENSMUST00000111803.3 ENSMUST00000111803.4 ENSMUST00000111803.5 ENSMUST00000111803.6 ENSMUST00000111803.7 ENSMUST00000111803.8 NM_023042 Q3TPI5 Q9Z128 Q9Z129 RECQ1_MOUSE Recql1 uc009epf.1 uc009epf.2 uc009epf.3 DNA helicase that plays a role in DNA damage repair and genome stability (By similarity). Exhibits a magnesium- and ATP- dependent DNA-helicase activity that unwinds single- and double- stranded DNA in a 3'-5' direction (By similarity). Plays a role in restoring regressed replication forks (By similarity). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (By similarity). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Reaction=dATP + H2O = dADP + H(+) + phosphate; Xref=Rhea:RHEA:51908, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57667, ChEBI:CHEBI:61404; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51909; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; May form homodimers or higher order oligomers (By similarity). Interacts with EXO1. Interacts with MLH1. Interacts with PARP1 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=Alpha; IsoId=Q9Z129-1; Sequence=Displayed; Name=Beta; IsoId=Q9Z129-2; Sequence=VSP_005567; [Isoform Alpha]: Expressed in all tissues examined. [Isoform Beta]: Only expressed in spermatocytes. Expression increases at pachytene (17 days old) and decreases after completion of meiosis II (7 weeks old). Belongs to the helicase family. RecQ subfamily. nucleotide binding double-strand break repair via homologous recombination DNA strand renaturation nucleic acid binding DNA binding DNA helicase activity helicase activity ATP binding nucleus nucleoplasm chromosome cytoplasm DNA unwinding involved in DNA replication DNA repair DNA recombination four-way junction helicase activity hydrolase activity DNA duplex unwinding annealing helicase activity uc009epf.1 uc009epf.2 uc009epf.3 
ENSMUST00000111807.5 Neurl1a ENSMUST00000111807.5 neuralized E3 ubiquitin protein ligase 1A, transcript variant 2 (from RefSeq NM_001163480.1) ENSMUST00000111807.1 ENSMUST00000111807.2 ENSMUST00000111807.3 ENSMUST00000111807.4 NEUL1_MOUSE NM_001163480 Neurl Neurl1 Q91ZT6 Q923S6 Q9CWF1 Q9QWF1 uc008huv.1 uc008huv.2 uc008huv.3 uc008huv.4 uc008huv.5 Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with CPEB3 (via N-terminal domain); the interaction increases CPEB3 ubiquitination. Interacts with DLL1 (PubMed:19723503). Q923S6; Q7TN99: Cpeb3; NbExp=9; IntAct=EBI-5376802, EBI-5376779; Cytoplasm, perinuclear region Cell membrane ; Peripheral membrane protein Perikaryon Cell projection, dendrite Postsynaptic density Note=Colocalized with JAG1 at the cell surface (By similarity). Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q923S6-1; Sequence=Displayed; Name=2; IsoId=Q923S6-2; Sequence=VSP_013152; Name=3; IsoId=Q923S6-3; Sequence=VSP_013153, VSP_013154; Expressed in CA1 pyramidal neurons (at protein level). Expressed throughout the adult forebrain, including the cerebral cortex, amygdala, striatum, and CA1 area of the hippocampus. Expressed in sensory neurons of the olfactory epithelium, the vomeronasal organ, mammary gland and skeletal muscle. Expressed in the somites at 8.5 dpc onwards. Up-regulated by synaptic activity. Myristoylation is a determinant of membrane targeting. According to PubMed:11585928, knockout male mice lacking Neurl1 are sterile due to a defect in axoneme organization in the spermatozoa that leads to compromised tail movement and sperm motility; knockout female mice lacking Neurl1 are defective in the final stages of mammary gland maturation during pregnancy. According to PubMed:11481456 knockout mice lacking Neurl1 are viable and morphologically normal but display an olfactory discrimination and are more sensitive to the effect of ethanol on motor coordination. ubiquitin-protein transferase activity protein binding cytoplasm plasma membrane regulation of translation protein monoubiquitination Notch signaling pathway sperm axoneme assembly nervous system development brain development skeletal muscle tissue development lactation negative regulation of cell proliferation postsynaptic density membrane protein ubiquitination transferase activity cell junction flagellated sperm motility dendrite cell projection positive regulation of apoptotic process dendritic spine perikaryon translation factor activity, non-nucleic acid binding synapse postsynaptic membrane positive regulation of epidermal growth factor-activated receptor activity negative regulation of Notch signaling pathway metal ion binding positive regulation of long-term neuronal synaptic plasticity perinuclear region of cytoplasm positive regulation of filopodium assembly positive regulation of dendritic spine development ubiquitin protein ligase activity cellular response to amino acid stimulus positive regulation of synapse maturation apical dendrite nucleus uc008huv.1 uc008huv.2 uc008huv.3 uc008huv.4 uc008huv.5 
ENSMUST00000111813.3 Calhm1 ENSMUST00000111813.3 calcium homeostasis modulator 1 (from RefSeq NM_001081271.1) CAHM1_MOUSE Calhm1 D3Z291 ENSMUST00000111813.1 ENSMUST00000111813.2 NM_001081271 uc008hus.1 uc008hus.2 uc008hus.3 Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP, required for sensory perception of sweet, bitter and umami tastes (PubMed:23467090). Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways (PubMed:23467090). Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (PubMed:29681531). Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration (PubMed:22711817). Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions (PubMed:22711817). Acts as an activator of the ERK1 and ERK2 cascade (By similarity). Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum (By similarity). May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner (By similarity). Inhibited by Gd(3+), Ruthenium Red, and Zn(2+) and partially inhibited by 2-aminoethoxydiphenyl borate. Homohexamer (By similarity). Associates with CALHM3 as a pore- forming subunit in an hetero-hexameric channel complex (PubMed:29681531). Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein. Note=Localizes to the basolateral membrane of epithelial cells including taste cells (PubMed:30804437). Colocalizes with HSPA5 at the endoplasmic reticulum (By similarity). Specifically expressed in type II taste bud cells. Not expressed in brain. Impaired perceptions of sweet, bitter and umami compounds. Mice are viable and fertile, with no visible morphological abnormalities in their taste buds or any altered expression of taste- related marker genes. They do however display a loss of both preference for sweet and umami compounds and for avoidance of bitter compounds. Perceptions of sour and salty tastes are unaffected. Reduced voltage- gated currents in type II cells and taste-evoked ATP release from taste buds without affecting the excitability of taste cells by taste stimuli. Elderly males and females do not show defects in spatial learning and memory retrieving. Belongs to the CALHM family. calcium activated cation channel activity voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane ion transport cation transport calcium ion transport ATP transport membrane integral component of membrane regulation of ion transmembrane transport identical protein binding sensory perception of taste sensory perception of bitter taste sensory perception of sweet taste sensory perception of umami taste protein homooligomerization calcium ion transmembrane transport uc008hus.1 uc008hus.2 uc008hus.3 
ENSMUST00000111816.3 Trim71 ENSMUST00000111816.3 tripartite motif-containing 71 (from RefSeq NM_001042503.2) ENSMUST00000111816.1 ENSMUST00000111816.2 Gm1127 LIN41_MOUSE Lin41 NM_001042503 Q1PSW8 uc009rxp.1 uc009rxp.2 uc009rxp.3 uc009rxp.4 E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (PubMed:19898466). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression (PubMed:22735451). In addition, participates in post- transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (PubMed:22735451). Specific regulator of miRNA biogenesis. miRNA Binds MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts (via NHL repeats) with AGO2; the interaction increases in presence of RNA (PubMed:19898466, PubMed:22508726, PubMed:22735451). Interacts with HSP90AA1. Interacts (via NHL repeats) with MOV10, PABPC1, PUM1, PUM2, STAU2, XRN1 and XRN2 in an RNA- dependent manner (By similarity). Interacts with SHCBP1; leading to enhance its stability (PubMed:22508726). Cytoplasm, P-body Highly expressed in undifferentiated embryonic stem cells (ESCs). Expressed in the epiblast and in interfollicular epidermal stem cells during early development. Also expressed in male germ cells and in the reproductive tract. Highly expressed in neuroepithelial cells, and its expression declines as neurogenesis proceeds (at protein level). Expressed in ependymal cells of the brain (PubMed:25883935). Expression is first detected at 8.5 dpc, increases to highest levels at 14.5 dpc and remains elevated through the newborn stage. Expressed in developing limb buds and tail buds starting from 9.5 dpc. At 9.5 dpc, expression is prominent in the entire embryo, with the exception of the primordial cardiac sac. At 10.5 dpc, expression reduces to the neuroepithelium, branchial arches, spinal cord, somites, limb, and tail buds. At the onset of central nervous system development, the neuroepithelium shows a prominent staining between 9.5 dpc and 10.5 dpc. Thereafter, expression is unevenly distributed in a progressively thinner layer along the inner surface of the ventricle. Expression is intense at the bumps corresponding to the nascent limb buds around 10.5 dpc. Shortly thereafter, as the limb buds emerge from the body and expand, expression declines and is limited to the most distal surface at 12.5 dpc. At 13.5 dpc it is no longer possible to identify expression in either the developing nervous system, the limb or the tail buds. From postnatal day 10 (P10) to the adulthood, expressed in cells lining the wall of the four ventricles of the postnatal brain (PubMed:25883935). Negatively regulated by the microRNA (miRNA) let-7 which causes degradation of the mRNA encoding this protein. This requires a let-7 complementary site (LCS) in the 3'-UTR of the mRNA encoding this protein. The NHL domain, containing the 6 NHL repeats, is necessary and sufficient to target RNA but not to repress mRNA. The minimal region needed to execute repression consists of the coiled coil domain and the Filamin repeat. The RING-type domain is dispensable for mRNA repression. Autoubiquitinated. Embryonic lethality at 9.5 dpc, due to a neural tube closure defect in the anterior craniofacial region of the neural tube, corresponding to the forebrain/midbrain boundary. Reduced cell proliferation in the neuroepithelium. Belongs to the TRIM/RBCC family. Reported to mediate ubiquitination and subsequent degradation of AGO2 (PubMed:19898466). However, this result is subject to discussion and later reports suggest that, while it interacts with AGO2, it is not involved in AGO2 ubiquitination (PubMed:22508726, PubMed:22735451). G1/S transition of mitotic cell cycle protein polyubiquitination P-body neural tube closure RNA binding ubiquitin-protein transferase activity protein binding cytoplasm multicellular organism development zinc ion binding fibroblast growth factor receptor signaling pathway miRNA metabolic process posttranscriptional regulation of gene expression protein ubiquitination transferase activity negative regulation of translation neural tube development translation repressor activity gene silencing by RNA production of miRNAs involved in gene silencing by miRNA miRNA binding miRNA mediated inhibition of translation proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding regulation of protein metabolic process protein autoubiquitination regulation of gene silencing by miRNA 3'-UTR-mediated mRNA destabilization ubiquitin protein ligase activity cellular response to organic substance stem cell proliferation regulation of neural precursor cell proliferation positive regulation of gene silencing by miRNA uc009rxp.1 uc009rxp.2 uc009rxp.3 uc009rxp.4 
ENSMUST00000111817.8 Gmfb ENSMUST00000111817.8 glia maturation factor, beta (from RefSeq NM_022023.2) ENSMUST00000111817.1 ENSMUST00000111817.2 ENSMUST00000111817.3 ENSMUST00000111817.4 ENSMUST00000111817.5 ENSMUST00000111817.6 ENSMUST00000111817.7 GMFB_MOUSE NM_022023 Q3UQX5 Q9CQI3 Q9ERL8 uc007thh.1 uc007thh.2 uc007thh.3 This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. Phosphorylated; stimulated by phorbol ester. Belongs to the actin-binding proteins ADF family. GMF subfamily. actin binding signal transduction learning locomotory behavior growth factor activity actin cortical patch negative regulation of Arp2/3 complex-mediated actin nucleation actin filament debranching Arp2/3 complex binding uc007thh.1 uc007thh.2 uc007thh.3 
ENSMUST00000111819.8 Cwc22 ENSMUST00000111819.8 CWC22 spliceosome-associated protein, transcript variant 19 (from RefSeq NR_185472.1) B1AYU7 B1AYU7_MOUSE Cwc22 ENSMUST00000111819.1 ENSMUST00000111819.2 ENSMUST00000111819.3 ENSMUST00000111819.4 ENSMUST00000111819.5 ENSMUST00000111819.6 ENSMUST00000111819.7 NR_185472 uc008kge.1 uc008kge.2 uc008kge.3 uc008kge.4 uc008kge.5 Nucleus speckle Belongs to the CWC22 family. RNA binding uc008kge.1 uc008kge.2 uc008kge.3 uc008kge.4 uc008kge.5 
ENSMUST00000111820.4 Tmppe ENSMUST00000111820.4 transmembrane protein with metallophosphoesterase domain (from RefSeq NM_001200002.1) D3Z286 D3Z286_MOUSE ENSMUST00000111820.1 ENSMUST00000111820.2 ENSMUST00000111820.3 Glb1 NM_001200002 Tmppe uc033jnl.1 uc033jnl.2 uc033jnl.3 molecular_function cellular_component biological_process membrane integral component of membrane hydrolase activity uc033jnl.1 uc033jnl.2 uc033jnl.3 
ENSMUST00000111826.4 Gm15217 ENSMUST00000111826.4 predicted gene 15217 (from RefSeq NR_037981.1) ENSMUST00000111826.1 ENSMUST00000111826.2 ENSMUST00000111826.3 NR_037981 uc029siq.1 uc029siq.2 uc029siq.3 uc029siq.4 uc029siq.5 uc029siq.1 uc029siq.2 uc029siq.3 uc029siq.4 uc029siq.5 
ENSMUST00000111827.4 Slco1a6 ENSMUST00000111827.4 solute carrier organic anion transporter family, member 1a6, transcript variant 1 (from RefSeq NM_023718.3) ENSMUST00000111827.1 ENSMUST00000111827.2 ENSMUST00000111827.3 NM_023718 Oatp5 Q3UQC6 Q99J94 Q9CUP7 SO1A6_MOUSE Slc21a13 uc009eow.1 uc009eow.2 uc009eow.3 uc009eow.4 May mediate the Na(+)-independent transport of organic anions. Cell membrane; Multi-pass membrane protein. Kidney specific. Not detected at birth and up to day 20. Intermediate levels were detected at day 40 and adult levels were reached at day 60. Belongs to the organo anion transporter (TC 2.A.60) family. plasma membrane integral component of plasma membrane xenobiotic metabolic process ion transport bile acid metabolic process bile acid transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity bile acid and bile salt transport membrane integral component of membrane animal organ regeneration multicellular organism growth heme metabolic process response to drug cholesterol homeostasis sodium-independent organic anion transport transmembrane transport triglyceride homeostasis uc009eow.1 uc009eow.2 uc009eow.3 uc009eow.4 
ENSMUST00000111831.8 Zfp385b ENSMUST00000111831.8 zinc finger protein 385B, transcript variant 1 (from RefSeq NM_178723.6) ENSMUST00000111831.1 ENSMUST00000111831.2 ENSMUST00000111831.3 ENSMUST00000111831.4 ENSMUST00000111831.5 ENSMUST00000111831.6 ENSMUST00000111831.7 NM_178723 Q8BWQ7 Q8BXJ8 Z385B_MOUSE Zfp533 Znf385b Znf533 uc008kfz.1 uc008kfz.2 uc008kfz.3 uc008kfz.4 uc008kfz.5 uc008kfz.6 May play a role in p53/TP53-mediated apoptosis. Interacts with p53/TP53; the interaction is direct. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BXJ8-1; Sequence=Displayed; Name=2; IsoId=Q8BXJ8-2; Sequence=VSP_015981; Mainly expressed in developing brain. fibrillar center p53 binding nucleic acid binding nucleus apoptotic process zinc ion binding metal ion binding intrinsic apoptotic signaling pathway by p53 class mediator uc008kfz.1 uc008kfz.2 uc008kfz.3 uc008kfz.4 uc008kfz.5 uc008kfz.6 
ENSMUST00000111838.10 Clasp2 ENSMUST00000111838.10 CLIP associating protein 2, transcript variant 1 (from RefSeq NM_029633.2) Clasp2 E9Q8N5 E9Q8N5_MOUSE ENSMUST00000111838.1 ENSMUST00000111838.2 ENSMUST00000111838.3 ENSMUST00000111838.4 ENSMUST00000111838.5 ENSMUST00000111838.6 ENSMUST00000111838.7 ENSMUST00000111838.8 ENSMUST00000111838.9 NM_029633 uc009rwv.1 uc009rwv.2 uc009rwv.3 uc009rwv.1 uc009rwv.2 uc009rwv.3 
ENSMUST00000111861.4 Pdcd6ip ENSMUST00000111861.4 programmed cell death 6 interacting protein, transcript variant 1 (from RefSeq NM_001164677.1) Aip1 Alix ENSMUST00000111861.1 ENSMUST00000111861.2 ENSMUST00000111861.3 NM_001164677 O88695 O89014 PDC6I_MOUSE Q3TED2 Q8BSL8 Q8R0H5 Q99LR3 Q9QZN8 Q9WU78 uc009rwo.1 uc009rwo.2 uc009rwo.3 uc009rwo.4 Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (By similarity). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (PubMed:27336173). Self-associates (By similarity). Interacts with SH3KBP1 (By similarity). Interacts with PDCD6 in a calcium-dependent manner (By similarity). Interacts with TSG101 in a calcium-dependent manner; PDCD6IP homooligomerization may be required for TSG101-binding (By similarity). Interacts with SGSM3 (By similarity). Directly interacts with CHMP4A, CHMP4B and CHMP4C (By similarity). Directly interacts with CEP55 in a 1:2 stoechiometry; this interaction is required for PDCD6IP targeting to the midbody (By similarity). May interact with PDGFRB (By similarity). Interacts with SH3GL1 and SH3GL2/endophilin-1 (By similarity). Forms a complex with SDCBP and SDC2 (PubMed:22660413). Found in a complex with F-actin, TJP1/ZO-1 and PARD3 (PubMed:27336173). Interacts with CD2AP (By similarity). Interacts with ARRDC1 (By similarity). Q9WU78; Q8CIH5: Plcg2; NbExp=7; IntAct=EBI-641897, EBI-617954; Q9WU78; O08992: Sdcbp; NbExp=3; IntAct=EBI-641897, EBI-538265; Q9WU78-1; Q9CQY1: Atg12; NbExp=3; IntAct=EBI-15788421, EBI-2911788; Q9WU78-1; Q9WU78-1: Pdcd6ip; NbExp=6; IntAct=EBI-15788421, EBI-15788421; Q9WU78-1; Q9H444: CHMP4B; Xeno; NbExp=2; IntAct=EBI-15788421, EBI-749627; Q9WU78-1; P17931: LGALS3; Xeno; NbExp=2; IntAct=EBI-15788421, EBI-1170392; Cytoplasm, cytosol Melanosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Secreted, extracellular exosome Cell junction, tight junction Midbody, Midbody ring Note=Colocalized with CEP55 in the midbody during cytokinesis and at centrosomes in non-dividing cells (By similarity). Component of the actomyosin-tight junction complex (PubMed:27336173). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9WU78-1; Sequence=Displayed; Name=2; Synonyms=Alix-SF, Short; IsoId=Q9WU78-2; Sequence=VSP_007502; Name=3; IsoId=Q9WU78-3; Sequence=VSP_007501; Ubiquitously expressed (PubMed:27336173). High expression in choroid plexus and low expression in cerebral cortex (at protein level) (PubMed:27336173). May be phosphorylated on tyrosine residues by activated PDGFRB. Deficient mice are viable and have a normal lifespan, although they are smaller in size. Mutant mice develop progressive and severe bilateral hydrocephalus (PubMed:27336173). [Isoform 2]: Does not interact with ALG-2. mitotic cytokinesis actomyosin contractile ring assembly immunological synapse protein binding extracellular region cytoplasm microtubule organizing center cytosol cytoskeleton bicellular tight junction apoptotic process cell cycle regulation of centrosome duplication protein transport SH3 domain binding cell junction proteinase activated receptor binding viral budding via host ESCRT complex melanosome actomyosin identical protein binding protein homodimerization activity myelin sheath maintenance of epithelial cell apical/basal polarity viral budding protein dimerization activity calcium-dependent protein binding protein homooligomerization cell division extracellular exosome bicellular tight junction assembly endoplasmic reticulum exit site Flemming body regulation of membrane permeability ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway positive regulation of exosomal secretion regulation of extracellular exosome assembly positive regulation of extracellular exosome assembly uc009rwo.1 uc009rwo.2 uc009rwo.3 uc009rwo.4 
ENSMUST00000111863.9 Gm5930 ENSMUST00000111863.9 predicted gene 5930 (from RefSeq NM_001374091.2) D3Z257 D3Z257_MOUSE ENSMUST00000111863.1 ENSMUST00000111863.2 ENSMUST00000111863.3 ENSMUST00000111863.4 ENSMUST00000111863.5 ENSMUST00000111863.6 ENSMUST00000111863.7 ENSMUST00000111863.8 Gm5930 NM_001374091 uc288suy.1 uc288suy.2 membrane integral component of membrane uc288suy.1 uc288suy.2 
ENSMUST00000111869.3 Gm3676 ENSMUST00000111869.3 Gm3676 (from geneSymbol) D3Z236 D3Z236_MOUSE ENSMUST00000111869.1 ENSMUST00000111869.2 Gm3676 uc288soe.1 uc288soe.2 molecular_function cellular_component biological_process uc288soe.1 uc288soe.2 
ENSMUST00000111870.3 Gm3543 ENSMUST00000111870.3 Gm3543 (from geneSymbol) D3Z235 D3Z235_MOUSE ENSMUST00000111870.1 ENSMUST00000111870.2 Gm3543 uc288sos.1 uc288sos.2 molecular_function cellular_component biological_process uc288sos.1 uc288sos.2 
ENSMUST00000111879.5 Dclk3 ENSMUST00000111879.5 doublecortin-like kinase 3 (from RefSeq NM_172928.5) DCLK3_MOUSE Dcamkl3 ENSMUST00000111879.1 ENSMUST00000111879.2 ENSMUST00000111879.3 ENSMUST00000111879.4 NM_172928 Q1A748 Q8BWQ5 uc009rvv.1 uc009rvv.2 uc009rvv.3 uc009rvv.4 This gene encodes a member of the protein kinase superfamily and the doublecortin family. Differently from the other two closely related family members (DCLK1 and DCLK2), the protein encoded by this gene contains only one N-terminal doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. The protein contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. [provided by RefSeq, Sep 2010]. CCDS Note: The coding region has been updated to extend the N-terminus to one that is supported by available conservation data. This would result in a protein that is 171 aa longer at the N-terminal. ##Evidence-Data-START## Transcript exon combination :: AK135010.1, DQ286388.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Q8BWQ5; O75528: TADA3; Xeno; NbExp=2; IntAct=EBI-16518538, EBI-473249; Cytoplasm Nucleus Highly expressed in brain and to a lower extent in liver and kidney. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Sequence=AAH56929.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC34182.1; Type=Frameshift; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction negative regulation of protein localization to nucleus uc009rvv.1 uc009rvv.2 uc009rvv.3 uc009rvv.4 
ENSMUST00000111888.3 Ccrl2 ENSMUST00000111888.3 C-C motif chemokine receptor-like 2, transcript variant 1 (from RefSeq NM_017466.5) CCRL2_MOUSE Ccr11 ENSMUST00000111888.1 ENSMUST00000111888.2 Lccr NM_017466 O35457 O70171 Q3UKM6 Q4FK04 Q91YD7 uc009rvk.1 uc009rvk.2 uc009rvk.3 uc009rvk.4 Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine- triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity). Cell membrane ; Multi-pass membrane protein Expressed in macrophages, astrocytes, in glial cells. Constitutively expressed by mast cells. Detected in bronchial epithelium in OVA-induced airway inflammation. Up-regulated during dendritic cell (DC) maturation. By bacterial lipopolysaccharide in astrocytes. Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors. No visible phenotype. Deficient-mice have normal numbers of mast cells in all tissues analyzed. Wild-type and deficient mice develop marked local inflammation when sensitized with a high dose of DNP-specific IgE, however deficient mice have significantly reduced IgE-dependent passive cutaneous anaphylaxis (PCA) reactions when lower sensitizing dose is used. Deficient-mice show normal recruitment of circulating DC into the lung, but a defective trafficking of antigen- loaded lung DC to mediastinal lymph nodes. This defect was associated to a reduction in lymph node cellularity and reduced priming of T- helper cell 2 response. It was initially reported that CCRL2 responds functionally to CCL2, CCL5, CCL7, and CCL8 via intracellular calcium mobilization and transwell chemotaxis although no evidence for a direct ligand-receptor interaction was provided in this report (PubMed:14999816). These results are now controversial and other studies failed to confirm CCRL2 recognition and transwell chemotaxis of these chemokines or a series of other CC- and CXC-chemokines using CCRL2-transfected cells (PubMed:18794339). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity chemokine receptor activity cytoplasm plasma membrane integral component of plasma membrane chemotaxis inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration external side of plasma membrane membrane integral component of membrane C-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding chemokine receptor binding CCR chemokine receptor binding cell chemotaxis chemokine-mediated signaling pathway uc009rvk.1 uc009rvk.2 uc009rvk.3 uc009rvk.4 
ENSMUST00000111899.8 Pprc1 ENSMUST00000111899.8 peroxisome proliferative activated receptor, gamma, coactivator-related 1, transcript variant 1 (from RefSeq NM_001081214.1) ENSMUST00000111899.1 ENSMUST00000111899.2 ENSMUST00000111899.3 ENSMUST00000111899.4 ENSMUST00000111899.5 ENSMUST00000111899.6 ENSMUST00000111899.7 Kiaa0595 NM_001081214 PPRC1_MOUSE Q3UGG3 Q6NZN1 Q80TW6 Q8BXP6 Q91YW8 uc008hsd.1 uc008hsd.2 uc008hsd.3 Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes (By similarity). Interacts with CREB1 and NRF1. Nucleus Note=Colocalizes with NRF1. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q6NZN1-1; Sequence=Displayed; Name=2; IsoId=Q6NZN1-2; Sequence=VSP_027233, VSP_027235; Name=3; IsoId=Q6NZN1-3; Sequence=VSP_027234, VSP_027236, VSP_027237; Name=4; IsoId=Q6NZN1-4; Sequence=VSP_027232; Name=5; IsoId=Q6NZN1-5; Sequence=VSP_027233; Expressed in liver, heart, skeletal muscle, kidney and white and brown adipose tissues. Up-regulated by serum (at protein level). Up-regulated by serum. Up-regulated weakly in brown adipose tissue by exposure of animals to cold. Sequence=BAC65604.1; Type=Erroneous initiation; Evidence=; nucleic acid binding transcription cofactor activity RNA binding nucleus nucleoplasm transcription factor binding ligand-dependent nuclear receptor transcription coactivator activity positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity uc008hsd.1 uc008hsd.2 uc008hsd.3 
ENSMUST00000111908.3 Mmrn2 ENSMUST00000111908.3 multimerin 2 (from RefSeq NM_153127.3) A6H6E2 ENSMUST00000111908.1 ENSMUST00000111908.2 MMRN2_MOUSE Mmrn2 NM_153127 Q8BJX4 Q8K1Z7 uc007tav.1 uc007tav.2 uc007tav.3 uc007tav.4 Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it down-regulates KDR activation by binding VEGFA. Heteromer of p110, p125, p140 and p200 subunits; disulfide- linked. Interacts with VEGFA. Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=A6H6E2-1; Sequence=Displayed; Name=2 ; IsoId=A6H6E2-2; Sequence=VSP_053050; N- and O-glycosylated. Sequence=BAC37291.1; Type=Frameshift; Evidence=; angiogenesis cell migration involved in sprouting angiogenesis extracellular matrix structural constituent protein binding extracellular region basement membrane extracellular space negative regulation of vascular endothelial growth factor receptor signaling pathway extracellular matrix negative regulation of cell migration involved in sprouting angiogenesis uc007tav.1 uc007tav.2 uc007tav.3 uc007tav.4 
ENSMUST00000111909.8 Gsg1 ENSMUST00000111909.8 Membrane ; Multi- pass membrane protein (from UniProt E9QQ16) D87325 E9QQ16 E9QQ16_MOUSE ENSMUST00000111909.1 ENSMUST00000111909.2 ENSMUST00000111909.3 ENSMUST00000111909.4 ENSMUST00000111909.5 ENSMUST00000111909.6 ENSMUST00000111909.7 Gsg1 uc291jss.1 uc291jss.2 Membrane ; Multi- pass membrane protein Belongs to the GSG1 family. membrane integral component of membrane uc291jss.1 uc291jss.2 
ENSMUST00000111913.9 Odr4 ENSMUST00000111913.9 odr4 GPCR localization factor homolog, transcript variant 1 (from RefSeq NM_145511.2) ENSMUST00000111913.1 ENSMUST00000111913.2 ENSMUST00000111913.3 ENSMUST00000111913.4 ENSMUST00000111913.5 ENSMUST00000111913.6 ENSMUST00000111913.7 ENSMUST00000111913.8 NM_145511 ODR4_MOUSE Q3U8Y3 Q4PJX1 Q99J66 uc007cxz.1 uc007cxz.2 uc007cxz.3 May play a role in the trafficking of a subset of G-protein coupled receptors. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q4PJX1-1; Sequence=Displayed; Name=2; IsoId=Q4PJX1-2; Sequence=VSP_028102; Name=3; IsoId=Q4PJX1-3; Sequence=VSP_028101; Ubiquitously expressed. Belongs to the ODR-4 family. Sequence=BAE30884.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component protein localization membrane integral component of membrane uc007cxz.1 uc007cxz.2 uc007cxz.3 
ENSMUST00000111915.8 Fam234b ENSMUST00000111915.8 family with sequence similarity 234, member B, transcript variant 2 (from RefSeq NM_028982.4) ENSMUST00000111915.1 ENSMUST00000111915.2 ENSMUST00000111915.3 ENSMUST00000111915.4 ENSMUST00000111915.5 ENSMUST00000111915.6 ENSMUST00000111915.7 F234B_MOUSE Fam234b Kiaa1467 NM_028982 Q3TE07 Q5DTX5 Q8BYI8 Q8BYJ4 Q9CXB0 uc009eli.1 uc009eli.2 uc009eli.3 uc009eli.4 Membrane ; Single-pass membrane protein Golgi outpost Cytoplasm, cytoskeleton, microtubule organizing center Note=Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BYI8-1; Sequence=Displayed; Name=2; IsoId=Q8BYI8-2; Sequence=VSP_025825; Belongs to the FAM234 family. molecular_function cellular_component biological_process membrane integral component of membrane uc009eli.1 uc009eli.2 uc009eli.3 uc009eli.4 
ENSMUST00000111917.3 Shld2 ENSMUST00000111917.3 shieldin complex subunit 2, transcript variant 3 (from RefSeq NR_153399.1) E9Q8K3 ENSMUST00000111917.1 ENSMUST00000111917.2 Fam35a NR_153399 Q3UEN2 Rinn2 SHLD2_MOUSE Shld2 uc007tap.1 uc007tap.2 uc007tap.3 uc007tap.4 Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. Component of the shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and MAD2L2/REV7. Within the complex, SHLD2 forms a scaffold which interacts with a SHLD3-MAD2L2 subcomplex via its N-terminus, and with SHLD1 via its C-terminus. Interacts with TP53BP1. Interacts with RIF1. Chromosome Belongs to the SHLD2 family. molecular_function nucleus chromosome DNA repair cellular response to DNA damage stimulus site of double-strand break positive regulation of isotype switching negative regulation of double-strand break repair via homologous recombination positive regulation of double-strand break repair via nonhomologous end joining uc007tap.1 uc007tap.2 uc007tap.3 uc007tap.4 
ENSMUST00000111920.2 Plekha3 ENSMUST00000111920.2 pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 (from RefSeq NM_031256.3) ENSMUST00000111920.1 Fapp1 NM_031256 PKHA3_MOUSE Q9ERS4 uc012bxp.1 uc012bxp.2 uc012bxp.3 Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (By similarity). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (By similarity). Binds preferentially to PtdIns(4)P (By similarity). Negatively regulates APOB secretion from hepatocytes (By similarity). Interacts with GTP-bound ARF1 (By similarity). Interacts with SACM1L and VAPA and/or VAPB to form a ternary complex (By similarity). Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Note=Localizes to ER-trans Golgi network (TGN) contacts sites. The PH domain binds the small GTPase ARF1 and phosphatidylinositol-4-phosphate (PtdIns4P) with high selectivity, and is required for its recruitment to the trans-Golgi network (TGN). Golgi apparatus cytosol lipid binding membrane ER to Golgi ceramide transport ceramide transport phosphatidylinositol-4-phosphate binding ceramide 1-phosphate binding ceramide 1-phosphate transporter activity ceramide 1-phosphate transport uc012bxp.1 uc012bxp.2 uc012bxp.3 
ENSMUST00000111922.2 Gprc5d ENSMUST00000111922.2 G protein-coupled receptor, family C, group 5, member D, transcript variant 2 (from RefSeq NM_053118.1) ENSMUST00000111922.1 GPC5D_MOUSE NM_053118 Q8CJI0 Q8CJI1 Q9JIL6 uc009elf.1 uc009elf.2 Cell membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JIL6-1; Sequence=Displayed; Name=2; IsoId=Q9JIL6-2; Sequence=VSP_010009, VSP_010010; Belongs to the G-protein coupled receptor 3 family. Sequence=BAC20266.1; Type=Frameshift; Evidence=; Sequence=BAC20267.1; Type=Frameshift; Evidence=; molecular_function G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane protein kinase activator activity keratinization activation of protein kinase activity hair cycle intracellular membrane-bounded organelle receptor complex extracellular exosome uc009elf.1 uc009elf.2 
ENSMUST00000111928.8 Fgf8 ENSMUST00000111928.8 fibroblast growth factor 8, transcript variant 3 (from RefSeq NM_001166362.2) ENSMUST00000111928.1 ENSMUST00000111928.2 ENSMUST00000111928.3 ENSMUST00000111928.4 ENSMUST00000111928.5 ENSMUST00000111928.6 ENSMUST00000111928.7 Fgf8 NM_001166362 Q3V279 Q3V279_MOUSE uc008hri.1 uc008hri.2 uc008hri.3 uc008hri.4 Secreted Belongs to the heparin-binding growth factors family. fibroblast growth factor receptor binding extracellular region growth factor activity fibroblast growth factor receptor signaling pathway uc008hri.1 uc008hri.2 uc008hri.3 uc008hri.4 
ENSMUST00000111948.8 Kazald1 ENSMUST00000111948.8 Kazal-type serine peptidase inhibitor domain 1, transcript variant 1 (from RefSeq NM_001362398.1) Bono1 ENSMUST00000111948.1 ENSMUST00000111948.2 ENSMUST00000111948.3 ENSMUST00000111948.4 ENSMUST00000111948.5 ENSMUST00000111948.6 ENSMUST00000111948.7 Igfbprp10 KAZD1_MOUSE NM_001362398 Q14BR9 Q8BJ66 uc008hqs.1 uc008hqs.2 uc008hqs.3 Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly. Secreted, extracellular space, extracellular matrix Highly expressed in the spleen. Moderately expressed in the skin, lung and urinary bladder. Weakly expressed in the brain, tongue, esophagus, stomach, large intestine, liver and bone. Expressed in osteoblastic cells during bone regeneration. Expressed in secretory osteoblasts in the tooth. At 15 dpc embryos, weakly expressed in osteoblasts within the distal area of the ossification center of the mid-shaft region of the ulna and the radius. At 16 dpc embryos highly expressed in mandible, maxilla, frontal bone and ossification regions of the nasal septum. At 17 dpc embryos expression is localized to developing mandibular and maxillar bones, the frontal bones and in the nasal capsule surrounding the nasopharynx. Expression throughout the developing mandibular bone is found in 15 dpc-17 dpc embryos. Present in periosteum of the humerus at 16.5 dpc (at protein level). Up-regulated during the early phase of the bone regeneration. Up-regulated by BMP2 during osteoblast differentiation. ossification regulation of cell growth insulin-like growth factor binding extracellular region interstitial matrix multicellular organism development cell differentiation extracellular matrix organization extracellular matrix uc008hqs.1 uc008hqs.2 uc008hqs.3 
ENSMUST00000111956.9 Arhgap22 ENSMUST00000111956.9 Rho GTPase activating protein 22 (from RefSeq NM_153800.4) ENSMUST00000111956.1 ENSMUST00000111956.2 ENSMUST00000111956.3 ENSMUST00000111956.4 ENSMUST00000111956.5 ENSMUST00000111956.6 ENSMUST00000111956.7 ENSMUST00000111956.8 NM_153800 Q6QHH6 Q8BL80 Q8BVH4 Q8CHY5 RHG22_MOUSE uc007szm.1 uc007szm.2 uc007szm.3 uc007szm.4 Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1- dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. Interacts with VEZF1. Cytoplasm Nucleus Note=Mainly cytoplasmic. Some fraction is nuclear. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BL80-1; Sequence=Displayed; Name=2; IsoId=Q8BL80-2; Sequence=VSP_023706; Name=3; IsoId=Q8BL80-3; Sequence=VSP_023706, VSP_023707; Predominantly present in endothelial cells (at protein level). Sequence=BAC32603.1; Type=Frameshift; Evidence=; Sequence=BAC37178.1; Type=Frameshift; Evidence=; angiogenesis molecular_function GTPase activator activity nucleus cytoplasm signal transduction multicellular organism development cell differentiation positive regulation of GTPase activity glutamatergic synapse uc007szm.1 uc007szm.2 uc007szm.3 uc007szm.4 
ENSMUST00000111962.8 Hnrnpa3 ENSMUST00000111962.8 heterogeneous nuclear ribonucleoprotein A3, transcript variant c (from RefSeq NM_053263.1) ENSMUST00000111962.1 ENSMUST00000111962.2 ENSMUST00000111962.3 ENSMUST00000111962.4 ENSMUST00000111962.5 ENSMUST00000111962.6 ENSMUST00000111962.7 Hnrpa3 NM_053263 Q8BG05 Q8BHF8 ROA3_MOUSE uc008kel.1 uc008kel.2 uc008kel.3 uc008kel.4 Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing (By similarity). Identified in the spliceosome C complex. Nucleus Note=Component of ribonucleosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BG05-1; Sequence=Displayed; Name=2; IsoId=Q8BG05-2; Sequence=VSP_007350; nucleic acid binding RNA binding mRNA binding nucleus nucleoplasm spliceosomal complex cytoplasm mRNA processing RNA splicing postsynaptic density ribonucleoprotein granule neuron projection mRNA transport RNA transmembrane transporter activity catalytic step 2 spliceosome messenger ribonucleoprotein complex ribonucleoprotein complex uc008kel.1 uc008kel.2 uc008kel.3 uc008kel.4 
ENSMUST00000111978.8 Taok3 ENSMUST00000111978.8 TAO kinase 3, transcript variant 1 (from RefSeq NM_001199685.1) ENSMUST00000111978.1 ENSMUST00000111978.2 ENSMUST00000111978.3 ENSMUST00000111978.4 ENSMUST00000111978.5 ENSMUST00000111978.6 ENSMUST00000111978.7 NM_001199685 Q3V3B3 Q8BYC6 TAOK3_MOUSE uc008zfh.1 uc008zfh.2 uc008zfh.3 uc008zfh.4 uc008zfh.5 Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Self-associates. Interacts with ERN1 and TRAF2. Interaction with TRAF2 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation (By similarity). Cytoplasm Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress- activated MAPK cascade. Phosphorylated by LRRK2 (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. MAPK cascade nucleotide binding activation of MAPKK activity protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity ATP binding nucleus cytoplasm DNA repair protein phosphorylation cellular response to DNA damage stimulus mitotic G2 DNA damage checkpoint kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation activation of protein kinase activity positive regulation of stress-activated MAPK cascade positive regulation of JUN kinase activity negative regulation of JNK cascade positive regulation of JNK cascade protein autophosphorylation uc008zfh.1 uc008zfh.2 uc008zfh.3 uc008zfh.4 uc008zfh.5 
ENSMUST00000111983.9 Hoxd3 ENSMUST00000111983.9 homeobox D3 (from RefSeq NM_010468.2) ENSMUST00000111983.1 ENSMUST00000111983.2 ENSMUST00000111983.3 ENSMUST00000111983.4 ENSMUST00000111983.5 ENSMUST00000111983.6 ENSMUST00000111983.7 ENSMUST00000111983.8 Hoxd3 NM_010468 Q3UZR4 Q3UZR4_MOUSE uc008kee.1 uc008kee.2 uc008kee.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus Belongs to the Antp homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription, DNA-templated regulation of transcription, DNA-templated cell-matrix adhesion Notch signaling pathway multicellular organism development positive regulation of gene expression aggresome nuclear body sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc008kee.1 uc008kee.2 uc008kee.3 
ENSMUST00000111989.9 Cfhr4 ENSMUST00000111989.9 complement factor H-related 4, transcript variant 2 (from RefSeq NM_001160303.1) Cfhr4 E9Q8B5 E9Q8B5_MOUSE ENSMUST00000111989.1 ENSMUST00000111989.2 ENSMUST00000111989.3 ENSMUST00000111989.4 ENSMUST00000111989.5 ENSMUST00000111989.6 ENSMUST00000111989.7 ENSMUST00000111989.8 Gm4788 NM_001160303 uc007cwn.1 uc007cwn.2 uc007cwn.3 uc007cwn.4 Lacks conserved residue(s) required for the propagation of feature annotation. complement component C3b binding extracellular space biological_process heparin binding uc007cwn.1 uc007cwn.2 uc007cwn.3 uc007cwn.4 
ENSMUST00000111997.3 Tmem233 ENSMUST00000111997.3 transmembrane protein 233 (from RefSeq NM_001101546.3) D3Z1U7 ENSMUST00000111997.1 ENSMUST00000111997.2 NM_001101546 TM233_MOUSE Tmem233 uc012ecg.1 uc012ecg.2 uc012ecg.3 uc012ecg.4 Probable accessory protein of voltage-gated sodium channels. Interacts with the giant stinging tree toxin ExTxA (P0DQP3) (Probable). Interacts with Nav1.7/SCN9A (Probable). Interacts with Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, and Nav1.6/SCN8A (By similarity). Membrane ; Single- pass membrane protein Probably expressed in nociceptive neurons. Detected in dorsal root ganglion neurons. Decrease in pain behaviors (paw licks and flinches) following intraplantar injection of ExTxA toxin. Belongs to the CD225/Dispanin family. Sequence=EDL19832.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function biological_process membrane integral component of membrane uc012ecg.1 uc012ecg.2 uc012ecg.3 uc012ecg.4 
ENSMUST00000111998.9 Klra3 ENSMUST00000111998.9 killer cell lectin-like receptor, subfamily A, member 3, transcript variant 1 (from RefSeq NM_010648.3) ENSMUST00000111998.1 ENSMUST00000111998.2 ENSMUST00000111998.3 ENSMUST00000111998.4 ENSMUST00000111998.5 ENSMUST00000111998.6 ENSMUST00000111998.7 ENSMUST00000111998.8 KLRA3_MOUSE Ly-49c Ly49C NM_010648 Q3TWQ1 Q3ZB40 Q499I4 Q61154 Q61198 Q64257 Q64329 uc009eik.1 uc009eik.2 uc009eik.3 uc009eik.4 Receptor on natural killer (NK) cells for class I MHC. Homodimer; disulfide-linked. Membrane; Single-pass type II membrane protein. plasma membrane cell adhesion membrane integral component of membrane carbohydrate binding uc009eik.1 uc009eik.2 uc009eik.3 uc009eik.4 
ENSMUST00000111999.8 Prkab1 ENSMUST00000111999.8 Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C- terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). (from UniProt Q9R078) AAKB1_MOUSE AK153552 ENSMUST00000111999.1 ENSMUST00000111999.2 ENSMUST00000111999.3 ENSMUST00000111999.4 ENSMUST00000111999.5 ENSMUST00000111999.6 ENSMUST00000111999.7 Q91YN6 Q9R078 uc290ywi.1 uc290ywi.2 Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C- terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity). The glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound debranching enzyme or protein phosphatases can directly affect AMPK activity. Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. Belongs to the 5'-AMP-activated protein kinase beta subunit family. protein kinase activity AMP-activated protein kinase activity protein binding nucleus cytoplasm cytosol protein phosphorylation lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process positive regulation of gene expression protein kinase binding nucleotide-activated protein kinase complex macromolecular complex nail development regulation of catalytic activity protein heterooligomerization uc290ywi.1 uc290ywi.2 
ENSMUST00000112020.2 Klra10 ENSMUST00000112020.2 killer cell lectin-like receptor subfamily A, member 10 (from RefSeq NM_008459.2) ENSMUST00000112020.1 Klra10 NM_008459 Q9R1G6 Q9R1G6_MOUSE uc009eih.1 uc009eih.2 plasma membrane membrane integral component of membrane carbohydrate binding uc009eih.1 uc009eih.2 
ENSMUST00000112022.5 Camp ENSMUST00000112022.5 cathelicidin antimicrobial peptide (from RefSeq NM_009921.2) CAMP_MOUSE Camp Cnlp Cramp ENSMUST00000112022.1 ENSMUST00000112022.2 ENSMUST00000112022.3 ENSMUST00000112022.4 NM_009921 P51437 Q0VB78 uc009rsv.1 uc009rsv.2 uc009rsv.3 uc009rsv.4 This gene encodes a member of the cathelicidin family of antimicrobial peptides that play an important role in the defense against microbial infection. The encoded preproprotein undergoes proteolytic processing to generate a mature polypeptide before secretion by host cells such as neutrophils, epithelial cells and macrophages. Mice lacking the encoded protein exhibit increased susceptibility to group A streptococcus and Escherichia coli infections. [provided by RefSeq, Oct 2015]. CCDS Note: Owing to stop SNP rs48466509 in the reference strain, the CCDS translation is one amino-acid shorter than in the FVB and BALB/C strains. The UniProt translation for this locus, P51437, is derived from a BALB/C mRNA and is 173 amino-acids long, versus 172 for the CCDS model. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC120754.1, X94353.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849388, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Antimicrobial protein that is an integral component of the innate immune system (By similarity). Binds to bacterial lipopolysaccharides (LPS) (By similarity). [Cathelin-related antimicrobial peptide]: Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2. Secreted Vesicle Note=Stored as pro-peptide in granules and phagolysosomes of neutrophils. Expressed in granulocytes (at protein level) (PubMed:9148921). High expression in bone marrow and small intestine (PubMed:9148921, PubMed:8706928). Expressed in testis, spleen, stomach, and intestine (PubMed:9148921). Very low expression found in heart, lung and skeletal muscle (PubMed:9148921). No expression in brain, kidney or liver (PubMed:9148921). Expressed in the adult and in the embryo where it is detected at 12-18 dpc. Proteolytically cleaved by cathepsin CTSG. Belongs to the cathelicidin family. lipopolysaccharide binding response to yeast positive regulation of protein phosphorylation innate immune response in mucosa chronic inflammatory response extracellular region extracellular space cytoplasm defense response positive regulation of cell proliferation antibacterial humoral response antifungal humoral response modification of morphology or physiology of other organism specific granule defense response to bacterium cell projection innate immune response positive regulation of angiogenesis defense response to Gram-negative bacterium defense response to Gram-positive bacterium cytolysis by host of symbiont cells killing by host of symbiont cells cellular response to lipopolysaccharide cellular response to peptidoglycan cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor positive regulation of interleukin-8 secretion uc009rsv.1 uc009rsv.2 uc009rsv.3 uc009rsv.4 
ENSMUST00000112024.10 Chn1 ENSMUST00000112024.10 chimerin 1, transcript variant 3 (from RefSeq NM_001113246.2) A2ATM0 Arhgap2 CHIN_MOUSE ENSMUST00000112024.1 ENSMUST00000112024.2 ENSMUST00000112024.3 ENSMUST00000112024.4 ENSMUST00000112024.5 ENSMUST00000112024.6 ENSMUST00000112024.7 ENSMUST00000112024.8 ENSMUST00000112024.9 NM_001113246 Q3UGY3 Q7TQE5 Q8BWU6 Q91V57 Q9D9B3 uc008kdb.1 uc008kdb.2 uc008kdb.3 GTPase-activating protein for p21-rac and a phorbol ester receptor. May play an important role in neuronal signal-transduction mechanisms (By similarity). Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation. May also interact with EPHB1 and EPHB2. Q91V57-1; Q03137: Epha4; NbExp=2; IntAct=EBI-1539203, EBI-1539152; Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q91V57-1; Sequence=Displayed; Name=2; IsoId=Q91V57-2; Sequence=VSP_020145; Name=3; IsoId=Q91V57-3; Sequence=VSP_020146; Phosphorylated. Phosphorylation is EPHA4 kinase activity- dependent. Mice are viable and fertile but display a loss of coordination of limb movement which phenocopies the one of Epha4 mutant mice. GTPase activator activity protein binding signal transduction nervous system development motor neuron axon guidance intracellular signal transduction regulation of GTPase activity positive regulation of GTPase activity metal ion binding ephrin receptor binding ephrin receptor signaling pathway regulation of axonogenesis regulation of small GTPase mediated signal transduction uc008kdb.1 uc008kdb.2 uc008kdb.3 
ENSMUST00000112025.3 2310009B15Rik ENSMUST00000112025.3 RIKEN cDNA 2310009B15 gene (from RefSeq NM_001081226.1) 2310009B15Rik D3Z1T2 D3Z1T2_MOUSE ENSMUST00000112025.1 ENSMUST00000112025.2 NM_001081226 uc007cvw.1 uc007cvw.2 uc007cvw.3 molecular_function cellular_component biological_process uc007cvw.1 uc007cvw.2 uc007cvw.3 
ENSMUST00000112026.4 Lhx9 ENSMUST00000112026.4 LIM homeobox protein 9, transcript variant 3 (from RefSeq NM_001042577.1) ENSMUST00000112026.1 ENSMUST00000112026.2 ENSMUST00000112026.3 LHX9_MOUSE NM_001042577 Q6GQU4 Q9QYQ5 Q9QYQ6 Q9QZ00 Q9WU44 Q9WUH2 uc007cvu.1 uc007cvu.2 uc007cvu.3 uc007cvu.4 Involved in gonadal development. Interacts with LDB1 and LDB2. Q9WUH2; Q9CYZ8: Ssbp2; NbExp=3; IntAct=EBI-309943, EBI-309962; Nucleus Event=Alternative splicing; Named isoforms=4; Name=3; IsoId=Q9WUH2-3; Sequence=Displayed; Name=1; Synonyms=Beta; IsoId=Q9WUH2-1; Sequence=VSP_036430; Name=2; Synonyms=Alpha; IsoId=Q9WUH2-2; Sequence=VSP_036430, VSP_036431; Name=4; IsoId=Q9WUH2-4; Sequence=VSP_036431; Expressed in the dorsal thalamus and inner nuclei of the cerebellum. Expressed in urogenital ridges of mice at 9.5 dpc. Expressed in the nervous system at 10.5 dpc. Expressed in the forelimb and hindlimb buds, the caelomic cavity at the level of the urogenital ridge, including the gonads, the pancreas and liver epithelium at 11.5 dpc. Expressed widespread throughout the CNS alar neuroepithelium from 11.5 to 14.5 dpc. Expressed in pioneer neurons of the cerebral cortex. In the telencephalic vesicles, expressed in cerebral cortex, the hippocampus, the claustrum primordium, olfactory bulb primordium and the caudal ganglionic eminence (amygdaloid complex) at 13.5 dpc. In the diencephalon, expressed in the pretectum (p1 prosomere), the dorsal thalamus (except for a thin ventral band close to the alar-basal boundary), the epithalamus, the epiphysis in prosomere p2, the supraoptic-paraventricular area, the eminentia thalami (p4 prosomere), the retrochiasmatic area and the tuberal hypothalamus at 13.5 dpc. In the mesencephalon, expressed in the tectum, the walls of the hindbrain, in nuclei of the ventral midbrain and hindbrain at 13.5 dpc. In the spinal cord, expressed as a gradient in the dorsal part of the neuroepithelium at 13.5 dpc. In the neocortical neuroepithelium, expressed in the archicortex (in the dentate gyrus, CA3 and CA4), the diencephalon, the midbrain and hindbrain at 14.5 and 16.5 dpc. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription corepressor activity protein binding nucleus regulation of transcription, DNA-templated cell proliferation male gonad development female gonad development neuron differentiation gonad morphogenesis sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding dorsal spinal cord interneuron anterior axon guidance uc007cvu.1 uc007cvu.2 uc007cvu.3 uc007cvu.4 
ENSMUST00000112027.9 Colq ENSMUST00000112027.9 collagen like tail subunit of asymmetric acetylcholinesterase (from RefSeq NM_009937.3) COLQ_MOUSE ENSMUST00000112027.1 ENSMUST00000112027.2 ENSMUST00000112027.3 ENSMUST00000112027.4 ENSMUST00000112027.5 ENSMUST00000112027.6 ENSMUST00000112027.7 ENSMUST00000112027.8 NM_009937 O35348 Q08EK8 uc007sxv.1 uc007sxv.2 uc007sxv.3 uc007sxv.4 Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina. Homotrimer. Component of the asymmetric form of AChE, a disulfide-bonded oligomer composed of the collagenic subunits (Q) and a variable number of asymmetric catalytic subunits (T). The N-terminal of a collagenic subunit (Q) associates with the C-terminal of a catalytic subunit (T) (By similarity). Synapse The proline-rich attachment domain (PRAD) binds the AChE catalytic subunits. The triple-helical tail is stabilized by disulfide bonds at each end. Belongs to the COLQ family. extracellular matrix structural constituent protein binding collagen trimer extracellular space plasma membrane heparin binding regulation of synaptic growth at neuromuscular junction cell junction extracellular matrix organization extracellular matrix neuromuscular junction neurotransmitter catabolic process synapse skeletal muscle acetylcholine-gated channel clustering establishment of protein localization to membrane uc007sxv.1 uc007sxv.2 uc007sxv.3 uc007sxv.4 
ENSMUST00000112028.10 Erlin1 ENSMUST00000112028.10 ER lipid raft associated 1, transcript variant 3 (from RefSeq NM_001164360.1) A0A0R4J1G5 ENSMUST00000112028.1 ENSMUST00000112028.2 ENSMUST00000112028.3 ENSMUST00000112028.4 ENSMUST00000112028.5 ENSMUST00000112028.6 ENSMUST00000112028.7 ENSMUST00000112028.8 ENSMUST00000112028.9 ERLN1_MOUSE Erlin1 Keo4 NM_001164360 Q3UKI9 Q8CIH7 Q91X78 Spfh1 uc008hpe.1 uc008hpe.2 uc008hpe.3 uc008hpe.4 Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (By similarity). Forms a heteromeric complex with ERLIN2 (By similarity). In complex with ERLIN2, interacts with RNF170 (PubMed:21610068). Interacts with AMFR and SYVN1 (By similarity). Endoplasmic reticulum membrane ; Single-pass type II membrane protein Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. Belongs to the band 7/mec-2 family. Sequence=AAH11220.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH23849.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid metabolic process cholesterol metabolic process lipid binding cholesterol binding membrane integral component of membrane ER-associated ubiquitin-dependent protein catabolic process ubiquitin protein ligase binding SREBP signaling pathway macromolecular complex negative regulation of cholesterol biosynthetic process negative regulation of fatty acid biosynthetic process uc008hpe.1 uc008hpe.2 uc008hpe.3 uc008hpe.4 
ENSMUST00000112032.8 Klra9 ENSMUST00000112032.8 killer cell lectin-like receptor subfamily A, member 9 (from RefSeq NM_010651.3) ENSMUST00000112032.1 ENSMUST00000112032.2 ENSMUST00000112032.3 ENSMUST00000112032.4 ENSMUST00000112032.5 ENSMUST00000112032.6 ENSMUST00000112032.7 Klra9 NM_010651 Q2TJJ8 Q2TJJ8_MOUSE uc009ehw.1 uc009ehw.2 uc009ehw.3 uc009ehw.4 plasma membrane membrane integral component of membrane carbohydrate binding uc009ehw.1 uc009ehw.2 uc009ehw.3 uc009ehw.4 
ENSMUST00000112046.2 Zfp281 ENSMUST00000112046.2 zinc finger protein 281, transcript variant 1 (from RefSeq NM_001160251.1) ENSMUST00000112046.1 NM_001160251 Q3U063 Q4FK52 Q99LI5 ZN281_MOUSE Znf281 uc007cuw.1 uc007cuw.2 uc007cuw.3 uc007cuw.4 Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. Interacts with NANOG. Associates with the NuRD complex. Q99LI5; Q80Z64: Nanog; NbExp=5; IntAct=EBI-2312719, EBI-2312517; Nucleus Embryos die between embryonic day 7.5 (E7.5) and E8.5, due to dysregulation of pluripotency and lineage specific markers in embryonic stem cells (ESCs). Embryos show abnormal embryonic body differentiation. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus nucleoplasm embryonic body morphogenesis negative regulation of gene expression cell differentiation sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding stem cell differentiation uc007cuw.1 uc007cuw.2 uc007cuw.3 uc007cuw.4 
ENSMUST00000112047.10 Cutc ENSMUST00000112047.10 cutC copper transporter, transcript variant 1 (from RefSeq NM_001113562.1) CUTC_MOUSE ENSMUST00000112047.1 ENSMUST00000112047.2 ENSMUST00000112047.3 ENSMUST00000112047.4 ENSMUST00000112047.5 ENSMUST00000112047.6 ENSMUST00000112047.7 ENSMUST00000112047.8 ENSMUST00000112047.9 NM_001113562 Q9D8X1 uc008hov.1 uc008hov.2 uc008hov.3 uc008hov.4 May play a role in copper homeostasis. Can bind one Cu(1+) per subunit (By similarity). Homotetramer. Cytoplasm Nucleus Belongs to the CutC family. copper ion binding nucleus nucleoplasm nucleolus cytoplasm cytosol metal ion binding protein tetramerization copper ion homeostasis uc008hov.1 uc008hov.2 uc008hov.3 uc008hov.4 
ENSMUST00000112057.9 Klrc2 ENSMUST00000112057.9 Cell membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein (from UniProt Q9WTJ9) AF106010 ENSMUST00000112057.1 ENSMUST00000112057.2 ENSMUST00000112057.3 ENSMUST00000112057.4 ENSMUST00000112057.5 ENSMUST00000112057.6 ENSMUST00000112057.7 ENSMUST00000112057.8 Klrc2 Nkg2c Q9WTJ9 Q9WTJ9_MOUSE uc009egl.1 uc009egl.2 uc009egl.3 Cell membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein external side of plasma membrane membrane integral component of membrane carbohydrate binding uc009egl.1 uc009egl.2 uc009egl.3 
ENSMUST00000112063.9 Klrd1 ENSMUST00000112063.9 killer cell lectin-like receptor, subfamily D, member 1 (from RefSeq NM_010654.4) Cd94 ENSMUST00000112063.1 ENSMUST00000112063.2 ENSMUST00000112063.3 ENSMUST00000112063.4 ENSMUST00000112063.5 ENSMUST00000112063.6 ENSMUST00000112063.7 ENSMUST00000112063.8 KLRD1_MOUSE NM_010654 O54707 O54708 uc009egd.1 uc009egd.2 uc009egd.3 uc009egd.4 Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule MHC-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal. KLRD1-KLRC1 acts as an immune inhibitory receptor. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity. On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens. In MHC-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion. Upon MHC-E- peptide binding, transmits intracellular signals through KLRC1 immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHIP-1 and INPPL1/SHIP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules. KLRD1-KLRC2 acts as an immune activating receptor. On cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal sequence-derived peptides from non-classical MHC class Ib MHC-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon MHC-E- peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation. Can form disulfide-bonded heterodimer with NKG2 family members KLRC1 and KLRC2. KLRD1-KLRC1 heterodimer interacts with peptide-bound MHC-E-B2M heterotrimeric complex. KLRD1 plays a prominent role in directly interacting with MHC-E. KLRD1-KLRC1 interacts with much higher affinity with peptide-bound MHC-E-B2M than KLRD1-KLRC2. Interacts with the adapter protein TYROBP/DAP12; this interaction is required for cell surface expression and cell activation. Cell membrane ; Single-pass type II membrane protein natural killer cell mediated immunity plasma membrane external side of plasma membrane membrane integral component of membrane MHC class I protein complex binding MHC class Ib protein binding, via antigen binding groove carbohydrate binding receptor complex protein antigen binding uc009egd.1 uc009egd.2 uc009egd.3 uc009egd.4 
ENSMUST00000112064.8 Cacna1s ENSMUST00000112064.8 calcium channel, voltage-dependent, L type, alpha 1S subunit, transcript variant 2 (from RefSeq NM_001081023.3) CAC1S_MOUSE Cach1 Cach1b Cacn1 Cacnl1a3 E9Q7B5 E9QPX8 ENSMUST00000112064.1 ENSMUST00000112064.2 ENSMUST00000112064.3 ENSMUST00000112064.4 ENSMUST00000112064.5 ENSMUST00000112064.6 ENSMUST00000112064.7 F8VQE0 NM_001081023 Q02789 Q3UPG8 Q99240 uc007cuf.1 uc007cuf.2 Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. Channel activity is blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Component of a calcium channel complex consisting of a pore- forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (PubMed:28351836). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2 (By similarity). CACNA1S channel activity is modulated by the auxiliary subunits (CACNB1 or CACNB2, CACNG1 and CACNA2D1). Interacts with DYSF and JSRP1 (PubMed:12871958, PubMed:16550931, PubMed:16638807). Interacts with RYR1 (By similarity). Interacts with STAC, STAC2 and STAC3 (via their SH3 domains) (PubMed:29467163). Interacts with CALM (By similarity). Cell membrane, sarcolemma, T-tubule ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q02789-1; Sequence=Displayed; Name=2; IsoId=Q02789-2; Sequence=VSP_050420; Name=3; IsoId=Q02789-3; Sequence=VSP_050420, VSP_061231; Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage- sensor and are characterized by a series of positively charged amino acids at every third position. The loop between repeats II and III interacts with the ryanodine receptor, and is therefore important for calcium release from the endoplasmic reticulum necessary for muscle contraction. The alpha-1S subunit is found in two isoforms in the skeletal muscle: a minor form of 212 kDa containing the complete amino acid sequence, and a major form of 190 kDa derived from the full-length form by post-translational proteolysis close to Phe-1690. Phosphorylated. Phosphorylation by PKA activates the calcium channel. Both the minor and major forms are phosphorylated in vitro by PKA. Phosphorylation at Ser-1575 is involved in beta-adrenergic- mediated regulation of the channel. Note=Defects in Cacna1s are the cause of muscular dysgenesis (MDG), a lethal autosomal recessive disorder in which there is total lack of excitation-contraction coupling in homozygotes, and which results in complete skeletal muscle paralysis. A single nucleotide deletion yields a protein with an altered and truncated C-terminus. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1S subfamily. skeletal system development extraocular skeletal muscle development ion channel activity voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity calmodulin binding cytoplasm plasma membrane voltage-gated calcium channel complex ion transport calcium ion transport muscle contraction striated muscle contraction endoplasmic reticulum organization skeletal muscle tissue development myoblast fusion neuromuscular junction development high voltage-gated calcium channel activity membrane integral component of membrane sarcoplasmic reticulum T-tubule I band regulation of ion transmembrane transport sarcolemma skeletal muscle adaptation dendritic spine head metal ion binding skeletal muscle fiber development muscle cell development transmembrane transport calcium ion import calcium ion transmembrane transport cellular response to caffeine L-type voltage-gated calcium channel complex uc007cuf.1 uc007cuf.2 
ENSMUST00000112066.2 Sirt4 ENSMUST00000112066.2 sirtuin 4, transcript variant 2 (from RefSeq NM_133760.1) D3Z1D9 ENSMUST00000112066.1 NM_133760 Q8R216 SIR4_MOUSE Sir2l4 uc008zdz.1 uc008zdz.2 uc008zdz.3 uc008zdz.4 Acts as a NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase (PubMed:19220062). Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation (PubMed:23663782). Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (PubMed:23746352). Does not seem to deacetylate PC (PubMed:23438705). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310, PubMed:20685656). Down-regulates insulin secretion (By similarity). Reaction=H2O + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NAD(+) = 2''-O- lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:63640, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10474, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:83099, ChEBI:CHEBI:189572; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63641; Evidence= Reaction=H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) = 2''-O- biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:70479, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10505, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:83144, ChEBI:CHEBI:189573; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70480; Evidence=; Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43637; Evidence=; Reaction=L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP- D-ribosyl)-L-cysteinyl-[protein]; Xref=Rhea:RHEA:56612, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:14624, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29950, ChEBI:CHEBI:57540, ChEBI:CHEBI:140607; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Interacts with IDE and SLC25A5 (By similarity). Interacts with GLUD1 (PubMed:16959573). Interacts with DLAT and PDHX (By similarity). Interacts with MCCC1 (via the biotin carboxylation domain) (PubMed:23438705). Interacts with PCCA and PC (PubMed:23438705). Mitochondrion matrix Detected in kidney, heart, brain, liver and pancreatic islets (at protein level). Expression is directly activated by ATF4/CREB2. In response to mTORC1 signal, expression is down-regulated due to degradation of ATF4/CREB2 (PubMed:23663782). Induced following DNA damage (PubMed:23562301). The expression is strongly inhibited by fasting (PubMed:24043310). No visible phenotype. Decreased mitochondrial protein ADP-ribosylation. Increased plasma insulin levels. Mice develop lung tumors more frequently. Defects in lipid metabolism, leading to increased protection against diet-induced obesity. Animals show higher levels of NAD(+) in liver (PubMed:24043310). In the hepatic periportal zone, decreased number of mitochondria with an increase in their length (PubMed:24043310). According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant. Belongs to the sirtuin family. Class II subfamily. Sequence=AAH22653.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; regulation of glutamine family amino acid metabolic process NAD+ ADP-ribosyltransferase activity protein binding mitochondrion mitochondrial inner membrane mitochondrial matrix protein ADP-ribosylation protein deacetylation glutamine metabolic process cellular response to DNA damage stimulus zinc ion binding negative regulation of cardiac muscle cell apoptotic process transferase activity hydrolase activity NAD-dependent protein deacetylase activity peptidyl-lysine deacetylation negative regulation of fatty acid oxidation negative regulation of insulin secretion metal ion binding positive regulation of lipid biosynthetic process biotinidase activity lipoamidase activity NAD+ binding cellular response to hypoxia tricarboxylic acid metabolic process negative regulation of protein processing involved in protein targeting to mitochondrion regulation of pyruvate dehydrogenase activity uc008zdz.1 uc008zdz.2 uc008zdz.3 uc008zdz.4 
ENSMUST00000112070.8 Col7a1 ENSMUST00000112070.8 collagen, type VII, alpha 1 (from RefSeq NM_007738.4) CO7A1_MOUSE Col7a1 ENSMUST00000112070.1 ENSMUST00000112070.2 ENSMUST00000112070.3 ENSMUST00000112070.4 ENSMUST00000112070.5 ENSMUST00000112070.6 ENSMUST00000112070.7 NM_007738 Q63870 Q78EC6 uc292lkf.1 uc292lkf.2 Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. Homotrimer. Interacts with MIA3/TANGO1; facilitating its loading into transport carriers and subsequent secretion (By similarity). Q63870; Q63870: Col7a1; NbExp=2; IntAct=EBI-8313134, EBI-8313134; Secreted, extracellular space, extracellular matrix, basement membrane Transcription of COL7A1 is stimulated by TGFB1 in keratinocytes and this is possibly dependent on a putative interaction between SMADS and AP1. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Mice do not express type VII collagen in their skin; they are born with extensive cutaneous blistering and die during the first two weeks of life, possibly because of complications arising from blistering; this mouse mutant resembles the autosomal recessive inherited form of the dystrophic epidermolysis bullosa (DEB) in humans. Heterozygotes by comparison display a normal phenotype. growth plate cartilage chondrocyte morphogenesis serine-type endopeptidase inhibitor activity extracellular region collagen trimer basement membrane extracellular space cell adhesion negative regulation of peptidase activity negative regulation of endopeptidase activity extracellular matrix structural constituent conferring tensile strength peptidase inhibitor activity extracellular matrix identical protein binding uc292lkf.1 uc292lkf.2 
ENSMUST00000112082.9 Clec12b ENSMUST00000112082.9 C-type lectin domain family 12, member B, transcript variant 1 (from RefSeq NM_001204223.1) A0A0R4J0A7 A0A0R4J0A7_MOUSE Clec12b ENSMUST00000112082.1 ENSMUST00000112082.2 ENSMUST00000112082.3 ENSMUST00000112082.4 ENSMUST00000112082.5 ENSMUST00000112082.6 ENSMUST00000112082.7 ENSMUST00000112082.8 NM_001204223 uc009efn.1 uc009efn.2 uc009efn.3 uc009efn.4 Membrane ; Single- pass type II membrane protein natural killer cell inhibitory signaling pathway external side of plasma membrane membrane integral component of membrane protein phosphatase binding carbohydrate binding receptor inhibitor activity macromolecular complex negative regulation of natural killer cell mediated cytotoxicity negative regulation of receptor activity uc009efn.1 uc009efn.2 uc009efn.3 uc009efn.4 
ENSMUST00000112091.9 Rab9 ENSMUST00000112091.9 RAB9, member RAS oncogene family (from RefSeq NM_019773.2) ENSMUST00000112091.1 ENSMUST00000112091.2 ENSMUST00000112091.3 ENSMUST00000112091.4 ENSMUST00000112091.5 ENSMUST00000112091.6 ENSMUST00000112091.7 ENSMUST00000112091.8 NM_019773 Q9R0M6 RAB9A_MOUSE Rab9a Sid99 uc009uwu.1 uc009uwu.2 uc009uwu.3 uc009uwu.4 Involved in the transport of proteins between the endosomes and the trans-Golgi network (By similarity). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560). Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain) (By similarity). Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:25220469). Interacts with SGSM2 (PubMed:26620560). The GTP- bound form but not the GDP-bound form interacts with HPS4 (PubMed:26620560, PubMed:20048159). The GTP-bound form but not the GDP- bound form interacts with BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (By similarity). Q9R0M6; Q9R0M6: Rab9a; NbExp=2; IntAct=EBI-6552247, EBI-6552247; Q9R0M6; Q8BPQ7-1: Sgsm1; NbExp=8; IntAct=EBI-6552247, EBI-16121756; Cell membrane ; Lipid-anchor ; Cytoplasmic side Endoplasmic reticulum membrane Golgi apparatus membrane Late endosome Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasmic vesicle, phagosome Cytoplasmic vesicle membrane. Melanosome Note=Colocalizes with OSBPL1A at the late endosome. Recruited to phagosomes containing S.aureus or M.tuberculosis. Belongs to the small GTPase superfamily. Rab family. Golgi membrane nucleotide binding GTPase activity protein binding GTP binding lysosome endosome late endosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol plasma membrane intracellular protein transport protein transport membrane GDP binding cytoplasmic vesicle membrane phagocytic vesicle membrane cytoplasmic vesicle Rab protein signal transduction regulation of protein localization retrograde transport, endosome to Golgi melanosome identical protein binding phagocytic vesicle positive regulation of exocytosis negative regulation by host of symbiont molecular function uc009uwu.1 uc009uwu.2 uc009uwu.3 uc009uwu.4 
ENSMUST00000112096.9 Rnf10 ENSMUST00000112096.9 ring finger protein 10, transcript variant 2 (from RefSeq NM_016698.3) ENSMUST00000112096.1 ENSMUST00000112096.2 ENSMUST00000112096.3 ENSMUST00000112096.4 ENSMUST00000112096.5 ENSMUST00000112096.6 ENSMUST00000112096.7 ENSMUST00000112096.8 Kiaa0262 NM_016698 Q3UIW5 Q6PDS8 Q6ZQE8 Q91YZ9 Q9R0P0 RNF10_MOUSE Rie2 Rnf10 Sid2705 uc008zdl.1 uc008zdl.2 uc008zdl.3 The protein encoding this gene is a member of the really interesting new gene finger protein family. Members of this family contain protein motifs similar to zinc finger domains and are involved in many processes that include transcriptional regulation, DNA repair and signal transduction. Expression of this gene is upregulated during neuronal differentiation of cultured cells, and inhibition of its expression impairs differentiation and cell cycle exit, providing evidence for a function in neuronal differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling. Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome. Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation. The action of RNF10 in iRQC is counteracted by USP10 (By similarity). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with MEOX2. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UIW5-1; Sequence=Displayed; Name=2; IsoId=Q3UIW5-2; Sequence=VSP_021479, VSP_021480, VSP_021481; Belongs to the RNF10 family. Sequence=BAC97916.1; Type=Erroneous initiation; Evidence=; DNA binding ubiquitin-protein transferase activity nucleus cytoplasm negative regulation of Schwann cell proliferation positive regulation of myelination transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding protein autoubiquitination glutamatergic synapse postsynapse to nucleus signaling pathway uc008zdl.1 uc008zdl.2 uc008zdl.3 
ENSMUST00000112098.11 Pbrm1 ENSMUST00000112098.11 polybromo 1, transcript variant 3 (from RefSeq NM_001359855.1) ENSMUST00000112098.1 ENSMUST00000112098.10 ENSMUST00000112098.2 ENSMUST00000112098.3 ENSMUST00000112098.4 ENSMUST00000112098.5 ENSMUST00000112098.6 ENSMUST00000112098.7 ENSMUST00000112098.8 ENSMUST00000112098.9 F8VQD1 F8VQD1_MOUSE NM_001359855 Pbrm1 uc007swn.1 uc007swn.2 uc007swn.3 Nucleus DNA binding chromatin binding nucleus nucleoplasm chromatin remodeling negative regulation of cell proliferation RSC complex uc007swn.1 uc007swn.2 uc007swn.3 
ENSMUST00000112104.8 Mid1 ENSMUST00000112104.8 midline 1, transcript variant 1 (from RefSeq NM_010797.4) B1AV00 ENSMUST00000112104.1 ENSMUST00000112104.2 ENSMUST00000112104.3 ENSMUST00000112104.4 ENSMUST00000112104.5 ENSMUST00000112104.6 ENSMUST00000112104.7 Fxy NM_010797 O35418 O70583 Q7TPT6 TRI18_MOUSE Trim18 uc009uya.1 uc009uya.2 uc009uya.3 uc009uya.4 Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Homodimer or heterodimer with MID2. Interacts with IGBP1. O70583; Q9CQ20: Mid1ip1; NbExp=8; IntAct=EBI-472994, EBI-473024; Cytoplasm Cytoplasm, cytoskeleton Note=Microtubule-associated. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O70583-1; Sequence=Displayed; Name=2; IsoId=O70583-2; Sequence=VSP_005736; Name=3; IsoId=O70583-3; Sequence=VSP_010811, VSP_005736; Ubiquitously expressed in fetus and adult. At 9 dpc-10.5 dpc, highest expression found in frontonasal processes, branchial arches and CNS. From 12.5 dpc to 16.5 dpc, high levels found in rostral part of CNS. At 14.5 dpc, begins to be highly expressed in kidney and lung. At 16.5 dpc, highly expressed in the mucosa of the hindgut and cutaneous region of the stomach. Expressed throughout embryonic development with highest levels from 7-11 dpc. Also expressed in the adult. Phosphorylated. Belongs to the TRIM/RBCC family. Sequence=AAH53704.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; protein binding cytoplasm cytoskeleton microtubule cytoplasmic microtubule negative regulation of microtubule depolymerization microtubule binding zinc ion binding microtubule cytoskeleton transferase activity ubiquitin protein ligase binding positive regulation of stress-activated MAPK cascade protein localization to microtubule identical protein binding protein homodimerization activity metal ion binding protein heterodimerization activity phosphoprotein binding uc009uya.1 uc009uya.2 uc009uya.3 uc009uya.4 
ENSMUST00000112110.4 Klrb1 ENSMUST00000112110.4 killer cell lectin-like receptor subfamily B member 1 (from RefSeq NM_001099918.2) ENSMUST00000112110.1 ENSMUST00000112110.2 ENSMUST00000112110.3 Gm4696 KLRB1_MOUSE Klrb1d Klrb1g Klrb6 NM_001099918 Nkrp1g Q0ZUP1 Q1A4F6 uc009eem.1 uc009eem.2 uc009eem.3 Membrane ; Single-pass type II membrane protein protein binding membrane integral component of membrane carbohydrate binding signaling receptor activity uc009eem.1 uc009eem.2 uc009eem.3 
ENSMUST00000112115.2 Hccs ENSMUST00000112115.2 holocytochrome c synthetase, transcript variant 14 (from RefSeq NM_001410441.1) CCHL_MOUSE Cchl ENSMUST00000112115.1 Hccs NM_001410441 P53702 Q6P5G5 uc009uxx.1 uc009uxx.2 uc009uxx.3 uc009uxx.4 Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome. Reaction=holo-[cytochrome c] = apo-[cytochrome c] + heme b; Xref=Rhea:RHEA:22648, Rhea:RHEA-COMP:10725, Rhea:RHEA-COMP:10726, ChEBI:CHEBI:29950, ChEBI:CHEBI:60344, ChEBI:CHEBI:83739; EC=4.4.1.17; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22650; Evidence=; P53702; P51906: Slc1a1; NbExp=5; IntAct=EBI-8579982, EBI-8580001; P53702; Q60989: Xiap; NbExp=5; IntAct=EBI-8579982, EBI-517478; Mitochondrion inner membrane Membrane ; Lipid-anchor Belongs to the cytochrome c-type heme lyase family. holocytochrome-c synthase activity protein binding mitochondrion mitochondrial inner membrane membrane lyase activity cytochrome c-heme linkage metal ion binding uc009uxx.1 uc009uxx.2 uc009uxx.3 uc009uxx.4 
ENSMUST00000112118.8 Amelx ENSMUST00000112118.8 amelogenin, X-linked, transcript variant 2 (from RefSeq NM_009666.4) A2ALX2 A2ALX3 AMELX_MOUSE Amel ENSMUST00000112118.1 ENSMUST00000112118.2 ENSMUST00000112118.3 ENSMUST00000112118.4 ENSMUST00000112118.5 ENSMUST00000112118.6 ENSMUST00000112118.7 NM_009666 P45559 P63277 P70592 Q61293 uc009uxs.1 uc009uxs.2 uc009uxs.3 uc009uxs.4 Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. Interacts with KRT5. Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=4; IsoId=P63277-4; Sequence=Displayed; Name=1; IsoId=P63277-1, P45559-1; Sequence=VSP_011688; Name=2; Synonyms=LRAP; IsoId=P63277-2, P45559-2; Sequence=VSP_011688, VSP_000230; Name=3; IsoId=P63277-3, P45559-3; Sequence=VSP_011688, VSP_000231; Expressed in ameloblasts at the periphery of mandibular molars at P1 (PubMed:12657653). At P3 also expressed at the molar incisal region (PubMed:12657653). Expressed at the terminal of Tomes' processes of ameloblasts at the incisal region at P5 (PubMed:12657653). Several forms are produced by C-terminal processing. Phosphorylated by FAM20C in vitro. Belongs to the amelogenin family. calcium ion binding protein binding extracellular region basement membrane cell adhesion signal transduction multicellular organism development growth factor activity cell surface structural constituent of tooth enamel biomineral tissue development sodium ion binding macromolecular complex tooth mineralization regulation of cell proliferation odontogenesis of dentin-containing tooth identical protein binding protein homodimerization activity hydroxyapatite binding protein homooligomerization supramolecular complex uc009uxs.1 uc009uxs.2 uc009uxs.3 uc009uxs.4 
ENSMUST00000112121.6 Mlec ENSMUST00000112121.6 malectin (from RefSeq NM_175403.3) ENSMUST00000112121.1 ENSMUST00000112121.2 ENSMUST00000112121.3 ENSMUST00000112121.4 ENSMUST00000112121.5 Kiaa0152 MLEC_MOUSE Mlec NM_175403 Q6ZQI3 Q8C6C3 Q8CD40 Q8CI91 uc008zdf.1 uc008zdf.2 uc008zdf.3 uc008zdf.4 Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N- glycosylation (By similarity). Interacts with the oligosaccharyltransferase (OST) complex. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Belongs to the malectin family. Sequence=BAC97876.1; Type=Erroneous initiation; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane carbohydrate metabolic process membrane integral component of membrane enzyme binding carbohydrate binding uc008zdf.1 uc008zdf.2 uc008zdf.3 uc008zdf.4 
ENSMUST00000112131.9 Arhgap6 ENSMUST00000112131.9 Rho GTPase activating protein 6, transcript variant 2 (from RefSeq NM_178754.3) A2ABW4 A2AC55 ENSMUST00000112131.1 ENSMUST00000112131.2 ENSMUST00000112131.3 ENSMUST00000112131.4 ENSMUST00000112131.5 ENSMUST00000112131.6 ENSMUST00000112131.7 ENSMUST00000112131.8 NM_178754 O54834 Q3TMC2 Q8BG83 Q8C842 Q9QZL8 RHG06_MOUSE uc009uxo.1 uc009uxo.2 uc009uxo.3 uc009uxo.4 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O54834-1; Sequence=Displayed; Name=2; IsoId=O54834-2; Sequence=VSP_001643, VSP_001644; Name=3; IsoId=O54834-3; Sequence=VSP_026052, VSP_026053; Name=4; IsoId=O54834-4; Sequence=VSP_026051; Expressed in retina and lung. Sequence=BAC33263.1; Type=Erroneous initiation; Evidence=; Sequence=BAC37093.1; Type=Erroneous initiation; Evidence=; GTPase activator activity cytoplasm actin filament organization signal transduction activation of phospholipase C activity positive regulation of phospholipase activity actin cytoskeleton phospholipase activator activity SH3 domain binding regulation of GTPase activity phospholipase binding positive regulation of GTPase activity focal adhesion assembly negative regulation of stress fiber assembly negative regulation of focal adhesion assembly uc009uxo.1 uc009uxo.2 uc009uxo.3 uc009uxo.4 
ENSMUST00000112132.8 Pzp ENSMUST00000112132.8 PZP, alpha-2-macroglobulin like (from RefSeq NM_007376.4) A2m E9QPW0 ENSMUST00000112132.1 ENSMUST00000112132.2 ENSMUST00000112132.3 ENSMUST00000112132.4 ENSMUST00000112132.5 ENSMUST00000112132.6 ENSMUST00000112132.7 NM_007376 PZP_MOUSE Q60628 Q61838 Q6PEM2 uc009eef.1 uc009eef.2 Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Secreted. Highest expression in liver, medium expression in ovary, heart and stomach. Low expression in lung, kidney and uterus. Protein found in plasma. Unlike the rat protein, which is an acute phase protein, this protein is always in circulation at high levels. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. Sequence=AAA39508.1; Type=Frameshift; Evidence=; protease binding endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity extracellular region extracellular space embryo implantation negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity macromolecular complex binding brain-derived neurotrophic factor binding nerve growth factor binding uc009eef.1 uc009eef.2 
ENSMUST00000112142.8 Dync1i2 ENSMUST00000112142.8 dynein cytoplasmic 1 intermediate chain 2, transcript variant 3 (from RefSeq NM_001198874.1) Dync1i2 ENSMUST00000112142.1 ENSMUST00000112142.2 ENSMUST00000112142.3 ENSMUST00000112142.4 ENSMUST00000112142.5 ENSMUST00000112142.6 ENSMUST00000112142.7 NM_001198874 Q3TPJ8 Q3TPJ8_MOUSE uc008kah.1 uc008kah.2 uc008kah.3 uc008kah.4 uc008kah.5 Cytoplasm Belongs to the dynein intermediate chain family. cytoplasmic dynein complex microtubule-based movement uc008kah.1 uc008kah.2 uc008kah.3 uc008kah.4 uc008kah.5 
ENSMUST00000112149.9 Frmpd4 ENSMUST00000112149.9 Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate. (from UniProt A2AFR3) A2AFR3 AK147440 B9EIG4 ENSMUST00000112149.1 ENSMUST00000112149.2 ENSMUST00000112149.3 ENSMUST00000112149.4 ENSMUST00000112149.5 ENSMUST00000112149.6 ENSMUST00000112149.7 ENSMUST00000112149.8 FRPD4_MOUSE Gm196 Kiaa0316 Pdzd10 Pdzk10 Q3UHE4 Q3UHI9 Q80U41 uc292rtp.1 uc292rtp.2 uc292rtp.3 Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate. Interacts (via C-terminus) with DLG1, DLG2, DLG3 and DLG4/PSD95. Interacts (via N-terminus) with ARHGEF7; the interaction is mediated by the PDZ domain. Interacts with GPSM2 (via TPR repeat region). Cell projection, dendritic spine Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AFR3-1; Sequence=Displayed; Name=2; IsoId=A2AFR3-2; Sequence=VSP_028581; Name=3; IsoId=A2AFR3-3; Sequence=VSP_028582; Expressed in various regions of the brain, including cortex, hippocampus, cerebellum, olfactory bulb and medial habenular nucleus. The FERM domain mediates the interaction with phosphatidylinositol 4,5-bisphosphate. Sequence=BAC65526.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; phosphatidylinositol-4,5-bisphosphate binding cytoskeleton lipid binding postsynaptic density macromolecular complex cell projection dendritic spine positive regulation of synapse structural plasticity postsynaptic actin cytoskeleton organization glutamatergic synapse uc292rtp.1 uc292rtp.2 uc292rtp.3 
ENSMUST00000112152.8 Rhno1 ENSMUST00000112152.8 RAD9-HUS1-RAD1 interacting nuclear orphan 1, transcript variant 4 (from RefSeq NM_001326587.1) 5930416I19Rik E9Q1D4 E9Q1D4_MOUSE ENSMUST00000112152.1 ENSMUST00000112152.2 ENSMUST00000112152.3 ENSMUST00000112152.4 ENSMUST00000112152.5 ENSMUST00000112152.6 ENSMUST00000112152.7 NM_001326587 Rhno1 uc012eta.1 uc012eta.2 uc012eta.3 DNA damage checkpoint recombinational repair nucleus chromosome cellular response to UV positive regulation of G0 to G1 transition cellular response to ionizing radiation uc012eta.1 uc012eta.2 uc012eta.3 
ENSMUST00000112160.4 Gm57857 ENSMUST00000112160.4 RIKEN cDNA 1500011B03 gene, transcript variant 1 (from RefSeq NR_027817.1) 1500011B03Rik ENSMUST00000112160.1 ENSMUST00000112160.2 ENSMUST00000112160.3 NR_027817 Q3V495 Q3V495_MOUSE uc008zah.1 uc008zah.2 uc008zah.3 molecular_function cellular_component biological_process membrane integral component of membrane uc008zah.1 uc008zah.2 uc008zah.3 
ENSMUST00000112162.4 Or10h5 ENSMUST00000112162.4 olfactory receptor family 10 subfamily H member 5 (from RefSeq NM_001199062.1) ENSMUST00000112162.1 ENSMUST00000112162.2 ENSMUST00000112162.3 Gm4461 K7N6V7 K7N6V7_MOUSE NM_001199062 Olfr1564 Or10h5 uc012ape.1 uc012ape.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Nov 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc012ape.1 uc012ape.2 
ENSMUST00000112170.2 Tlr8 ENSMUST00000112170.2 toll-like receptor 8, transcript variant 1 (from RefSeq NM_133212.3) A2AHI9 ENSMUST00000112170.1 NM_133212 P58682 Q91XI7 TLR8_MOUSE uc009uwy.1 uc009uwy.2 uc009uwy.3 uc009uwy.4 Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR- containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively. Activated by RNAs having enough uridines. Homodimer (By similarity). Interacts with MYD88 via their respective TIR domains (Probable). Interacts with UNC93B1 (PubMed:19451267). Interacts with BTK (By similarity). Interacts with SMPDL3B (PubMed:26095358). Endosome membrane ; Single-pass type I membrane protein Note=Endosomal localization confers distinctive proteolytic processing. Ubiquitinated by RNF216; leading to degradation by the proteasome. Proteolytic processing occurs in monocytes and monocyte-derived macrophages by both furin-like proprotein convertase and cathepsins. The cleavage is necessary for dimer formation and subsequent activation. Belongs to the Toll-like receptor family. microglial cell activation regulation of protein phosphorylation toll-like receptor signaling pathway immune system process MyD88-dependent toll-like receptor signaling pathway DNA binding RNA binding double-stranded RNA binding single-stranded RNA binding transmembrane signaling receptor activity protein binding plasma membrane inflammatory response immune response signal transduction I-kappaB kinase/NF-kappaB signaling drug binding signaling pattern recognition receptor activity response to virus external side of plasma membrane membrane integral component of membrane positive regulation of interleukin-6 production toll-like receptor 8 signaling pathway identical protein binding positive regulation of interferon-gamma biosynthetic process innate immune response positive regulation of innate immune response positive regulation of interferon-alpha biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of interleukin-8 biosynthetic process regulation of cytokine secretion positive regulation of interleukin-1 beta secretion defense response to virus cellular response to mechanical stimulus positive regulation of interleukin-6 secretion negative regulation of interleukin-12 secretion uc009uwy.1 uc009uwy.2 uc009uwy.3 uc009uwy.4 
ENSMUST00000112172.4 Tmsb4x ENSMUST00000112172.4 thymosin, beta 4, X chromosome (from RefSeq NM_021278.2) ENSMUST00000112172.1 ENSMUST00000112172.2 ENSMUST00000112172.3 NM_021278 Q6ZWX2 Q6ZWX2_MOUSE Tmsb4x uc009uwx.1 uc009uwx.2 uc009uwx.3 Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Cytoplasm, cytoskeleton Belongs to the thymosin beta family. actin binding actin monomer binding cytoplasm cytoskeleton actin filament organization uc009uwx.1 uc009uwx.2 uc009uwx.3 
ENSMUST00000112173.8 Tspan9 ENSMUST00000112173.8 tetraspanin 9, transcript variant 6 (from RefSeq NM_001379136.1) ENSMUST00000112173.1 ENSMUST00000112173.2 ENSMUST00000112173.3 ENSMUST00000112173.4 ENSMUST00000112173.5 ENSMUST00000112173.6 ENSMUST00000112173.7 NM_001379136 Net5 Q3TQQ0 Q8BJU2 TSN9_MOUSE uc009ecq.1 uc009ecq.2 uc009ecq.3 Found in a complex with GP6. Membrane ; Multi- pass membrane protein Note=Colocalizes with GP6 in tetraspanin microdomains on the platelet surface. Strongly expressed in megakaryocytes, platelets and lung. Weakly expressed in bone marrow, brain and kidney (at protein level). Glycosylated. Belongs to the tetraspanin (TM4SF) family. molecular_function plasma membrane integral component of plasma membrane membrane integral component of membrane tetraspanin-enriched microdomain uc009ecq.1 uc009ecq.2 uc009ecq.3 
ENSMUST00000112186.9 Mettl8 ENSMUST00000112186.9 methyltransferase 8, methylcytidine, transcript variant a (from RefSeq NM_145524.4) A2AUU0 A2AUU3 ENSMUST00000112186.1 ENSMUST00000112186.2 ENSMUST00000112186.3 ENSMUST00000112186.4 ENSMUST00000112186.5 ENSMUST00000112186.6 ENSMUST00000112186.7 ENSMUST00000112186.8 METL8_MOUSE Mettl8 NM_145524 Q2XV35 Q2XV36 Q4FCR9 Q4FCS0 Q6PEN9 Q99KI7 Tip uc008jzx.1 uc008jzx.2 uc008jzx.3 uc008jzx.4 uc008jzx.5 uc008jzx.6 This locus encodes a member of the methyltransferase family, and is involved in chromatin remodeling. Transcripts from this locus can be induced or inhibited by cell stretch and affect cell differentiation in the myogenic or adipogenic pathways. Multiple transcript variants encoding different isoforms have been found for this gene. Additional splice variants have been described in the literature but they meet nonsense-mediated decay (NMD) criteria and are likely to be degraded as soon as they are transcribed. [provided by RefSeq, Jul 2008]. Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr) (By similarity). N(3)-methylcytidine methylation modification regulates mitochondrial translation efficiency and is required for activity of the respiratory chain (By similarity). N(3)- methylcytidine methylation of mitochondrial tRNA(Ser)(UCN) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by TRIT1 as prerequisite (By similarity). May also mediate N(3)-methylcytidine modification of mRNAs (PubMed:28655767). The existence of N(3)- methylcytidine modification on mRNAs is however unclear, and additional evidences are required to confirm the role of the N(3)-methylcytidine- specific mRNA methyltransferase activity of METTL8 in vivo (By similarity). [Isoform 5]: Overexpression in lung progenitor cells stimulates smooth muscle-specific gene expression and suppresses adipogenic gene expression. [Isoform 4]: Stimulates adipogenesis. [Isoform 7]: Stimulates adipogenesis. Reaction=cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:50956, Rhea:RHEA-COMP:12849, Rhea:RHEA-COMP:12851, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74894, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50957; Evidence=; Reaction=cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:50960, Rhea:RHEA-COMP:12850, Rhea:RHEA-COMP:12852, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74894, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50961; Evidence=; Reaction=a cytidine in mRNA + S-adenosyl-L-methionine = an N(3)- methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60916, Rhea:RHEA-COMP:15145, Rhea:RHEA-COMP:15713, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74894, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60917; Evidence=; Interacts with EP300. Mitochondrion Cytoplasm Nucleus Note=Mitochondrial protein (By similarity). The cytoplasmic or nuclear localization observed by some groups is either the result of an incorrect localization caused by N- terminal tagging that interferes with mitochondrial targeting, or splice isoforms that lack the N-terminal mitochondrial transit sequence (By similarity). [Isoform 5]: Nucleus Note=Isoform 5 localizes to the nucleus upon cell stretch in embryonic lung progenitor cells. Event=Alternative splicing; Named isoforms=9; Name=1; IsoId=A2AUU0-1; Sequence=Displayed; Name=2; Synonyms=TIP-2 ; IsoId=A2AUU0-2; Sequence=VSP_029516; Name=3; Synonyms=TIP-4 ; IsoId=A2AUU0-3; Sequence=VSP_029517; Name=4; Synonyms=TIP-3 ; IsoId=A2AUU0-4; Sequence=VSP_029518; Name=5; Synonyms=TIP-1 ; IsoId=A2AUU0-5; Sequence=VSP_029515; Name=6; Synonyms=TIP-5 ; IsoId=A2AUU0-6; Sequence=VSP_037111, VSP_029517; Name=7; Synonyms=TIP-6 ; IsoId=A2AUU0-7; Sequence=Not described; Name=8; Synonyms=TIP-7 ; IsoId=A2AUU0-8; Sequence=Not described; Name=9; Synonyms=TIP-8 ; IsoId=A2AUU0-9; Sequence=Not described; [Isoform 2]: Absent in embryonic lung but is induced in a fibroblast cell line by stretch. [Isoform 4]: Expressed in undifferentiated progenitor cells, while its expression is inhibited by stretch. [Isoform 5]: Absent in undifferentiated embryonic lung mesenchymal cells, but expression is induced by stretch. [Isoform 7]: Expressed in mature adipose tissue. [Isoform 5]: Induced in stretched embryonic lung mesenchymal cells. Mice were born with normal Mendelian ratio without developmental defects (PubMed:28655767). Cells show reduced N(3)-methylcytidine modification in mRNAs (PubMed:28655767). Belongs to the methyltransferase superfamily. METL family. According to some authors, contains a SANT domain but this domain is not detected by any prediction tool. Sequence=AAH04636.1; Type=Erroneous initiation; Evidence=; Sequence=AAH57960.1; Type=Miscellaneous discrepancy; Note=Sequence differs from the displayed sequence in the N-terminal region.; Evidence=; Sequence=AAZ04166.1; Type=Erroneous initiation; Evidence=; Sequence=AAZ04167.1; Type=Erroneous initiation; Evidence=; histone acetyltransferase activity nucleus cytoplasm skeletal muscle tissue development methyltransferase activity mRNA methyltransferase activity histone acetylation transferase activity tRNA methylation methylation fat cell differentiation tRNA (cytosine-3-)-methyltransferase activity mRNA methylation uc008jzx.1 uc008jzx.2 uc008jzx.3 uc008jzx.4 uc008jzx.5 uc008jzx.6 
ENSMUST00000112188.8 Tceanc ENSMUST00000112188.8 transcription elongation factor A (SII) N-terminal and central domain containing (from RefSeq NM_001007577.2) ENSMUST00000112188.1 ENSMUST00000112188.2 ENSMUST00000112188.3 ENSMUST00000112188.4 ENSMUST00000112188.5 ENSMUST00000112188.6 ENSMUST00000112188.7 NM_001007577 Q3US16 Q6NXL9 Q8BY92 TEANC_MOUSE uc009uwv.1 uc009uwv.2 uc009uwv.3 Sequence=BC067008; Type=Frameshift; Evidence=; molecular_function cellular_component nucleus transcription, DNA-templated uc009uwv.1 uc009uwv.2 uc009uwv.3 
ENSMUST00000112200.3 Dntt ENSMUST00000112200.3 deoxynucleotidyltransferase, terminal, transcript variant 2 (from RefSeq NM_001043228.1) Dntt ENSMUST00000112200.1 ENSMUST00000112200.2 NM_001043228 Q3UZ80 Q3UZ80_MOUSE uc008hlp.1 uc008hlp.2 uc008hlp.3 uc008hlp.4 Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.31; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Nucleus Belongs to the DNA polymerase type-X family. DNA binding DNA-directed DNA polymerase activity DNA nucleotidylexotransferase activity nucleus DNA metabolic process transferase activity nucleotidyltransferase activity DNA polymerase activity metal ion binding DNA biosynthetic process uc008hlp.1 uc008hlp.2 uc008hlp.3 uc008hlp.4 
ENSMUST00000112210.11 Prkcd ENSMUST00000112210.11 protein kinase C, delta, transcript variant 2 (from RefSeq NM_011103.4) ENSMUST00000112210.1 ENSMUST00000112210.10 ENSMUST00000112210.2 ENSMUST00000112210.3 ENSMUST00000112210.4 ENSMUST00000112210.5 ENSMUST00000112210.6 ENSMUST00000112210.7 ENSMUST00000112210.8 ENSMUST00000112210.9 NM_011103 Prkcd Q53YN4 Q53YN4_MOUSE uc007svh.1 uc007svh.2 uc007svh.3 uc007svh.4 Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence= Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP. Cytoplasm Cytoplasm, perinuclear region Nucleus Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity ATP binding nucleus cytoplasm protein phosphorylation apoptotic process cell cycle kinase activity phosphorylation transferase activity intracellular signal transduction metal ion binding perinuclear region of cytoplasm uc007svh.1 uc007svh.2 uc007svh.3 uc007svh.4 
ENSMUST00000112220.8 Rad51ap1 ENSMUST00000112220.8 RAD51 associated protein 1, transcript variant 2 (from RefSeq NM_001347455.1) A0A0R4J1H1 A0A0R4J1H1_MOUSE ENSMUST00000112220.1 ENSMUST00000112220.2 ENSMUST00000112220.3 ENSMUST00000112220.4 ENSMUST00000112220.5 ENSMUST00000112220.6 ENSMUST00000112220.7 NM_001347455 Rad51ap1 uc009dvj.1 uc009dvj.2 uc009dvj.3 double-stranded DNA binding single-stranded DNA binding RNA binding nucleus DNA repair uc009dvj.1 uc009dvj.2 uc009dvj.3 
ENSMUST00000112231.9 Entpd1 ENSMUST00000112231.9 ectonucleoside triphosphate diphosphohydrolase 1, transcript variant 2 (from RefSeq NM_009848.4) ENSMUST00000112231.1 ENSMUST00000112231.2 ENSMUST00000112231.3 ENSMUST00000112231.4 ENSMUST00000112231.5 ENSMUST00000112231.6 ENSMUST00000112231.7 ENSMUST00000112231.8 Entpd1 NM_009848 Q544U5 Q544U5_MOUSE uc008hlf.1 uc008hlf.2 uc008hlf.3 In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. Reaction=a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:36795, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.5; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Homodimer; disulfide-linked. Membrane ; Multi- pass membrane protein Belongs to the GDA1/CD39 NTPase family. membrane integral component of membrane hydrolase activity uc008hlf.1 uc008hlf.2 uc008hlf.3 
ENSMUST00000112238.9 Foxn2 ENSMUST00000112238.9 forkhead box N2, transcript variant 1 (from RefSeq NM_180974.5) E9Q7L6 E9Q7L6_MOUSE ENSMUST00000112238.1 ENSMUST00000112238.2 ENSMUST00000112238.3 ENSMUST00000112238.4 ENSMUST00000112238.5 ENSMUST00000112238.6 ENSMUST00000112238.7 ENSMUST00000112238.8 Foxn2 NM_180974 uc008dvn.1 uc008dvn.2 uc008dvn.3 uc008dvn.4 Nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated skeletal muscle cell differentiation intracellular membrane-bounded organelle sequence-specific DNA binding uc008dvn.1 uc008dvn.2 uc008dvn.3 uc008dvn.4 
ENSMUST00000112243.8 Myo3b ENSMUST00000112243.8 Probable actin-based motor with a protein kinase activity (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern (PubMed:26754646). Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:22264607). (from UniProt Q1EG27) A2AR19 AY830392 ENSMUST00000112243.1 ENSMUST00000112243.2 ENSMUST00000112243.3 ENSMUST00000112243.4 ENSMUST00000112243.5 ENSMUST00000112243.6 ENSMUST00000112243.7 MYO3B_MOUSE Q1EG26 Q1EG27 uc289wsn.1 uc289wsn.2 Probable actin-based motor with a protein kinase activity (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern (PubMed:26754646). Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:22264607). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts (via C-terminus) with ESPN (PubMed:26785147, PubMed:26926603). Interacts (via C-terminus) with ESPNL (PubMed:26926603). Cytoplasm, cytoskeleton Cell projection, stereocilium Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Myosin IIIB1; IsoId=Q1EG27-1; Sequence=Displayed; Name=2; Synonyms=Myosin IIIB2; IsoId=Q1EG27-2; Sequence=VSP_036028, VSP_023112; Expressed in the cochlear hair cells (at protein level) (PubMed:26754646). Expressed in utricle hair bundles (at protein level) (PubMed:26926603). MYO3B single knockout mice do not exhibit early hearing impairment whereas mice with a double knockout of MYO3A and MYO3B are profoundly deaf at 1 month of age. Cochlear hair bundles have abnormally long stereocilia and show dynamic shape defects during development. In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. microfilament motor activity nucleotide binding photoreceptor outer segment photoreceptor inner segment motor activity actin binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm cytoskeleton protein phosphorylation visual perception sensory perception of sound kinase activity phosphorylation myosin complex transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation stereocilium stereocilium tip filopodium tip cell projection protein autophosphorylation response to stimulus positive regulation of filopodium assembly auditory receptor cell stereocilium organization cochlea morphogenesis uc289wsn.1 uc289wsn.2 
ENSMUST00000112244.8 Ntf3 ENSMUST00000112244.8 neurotrophin 3, transcript variant 1 (from RefSeq NM_001164034.2) ENSMUST00000112244.1 ENSMUST00000112244.2 ENSMUST00000112244.3 ENSMUST00000112244.4 ENSMUST00000112244.5 ENSMUST00000112244.6 ENSMUST00000112244.7 NM_001164034 Ntf3 Q3V1A4 Q3V1A4_MOUSE uc012esx.1 uc012esx.2 uc012esx.3 This gene encodes a member of the neurotrophins that have a wide variety of functions in both neural and non-neural tissues. The encoded preproprotein undergoes proteolytic processing to generate a noncovalently linked homodimeric mature protein that can bind to the transmembrane receptor tyrosine kinases to initiate a series of signaling events. Mice lacking the encoded protein exhibit severe defects in the peripheral nervous system including a complete lack of spinal proprioceptive afferents and their peripheral sense organs. [provided by RefSeq, Sep 2016]. Seems to promote the survival of visceral and proprioceptive sensory neurons. Secreted Belongs to the NGF-beta family. activation of MAPK activity positive regulation of receptor internalization receptor binding neurotrophin receptor binding extracellular region transmembrane receptor protein tyrosine kinase signaling pathway growth factor activity positive regulation of cell proliferation membrane integral component of membrane positive regulation of cell migration activation of protein kinase B activity positive regulation of peptidyl-serine phosphorylation chemoattractant activity regulation of apoptotic process positive regulation of peptidyl-tyrosine phosphorylation negative regulation of peptidyl-tyrosine phosphorylation positive chemotaxis induction of positive chemotaxis activation of GTPase activity positive regulation of actin cytoskeleton reorganization uc012esx.1 uc012esx.2 uc012esx.3 
ENSMUST00000112250.6 Cacna1d ENSMUST00000112250.6 calcium channel, voltage-dependent, L type, alpha 1D subunit, transcript variant 1 (from RefSeq NM_028981.3) CAC1D_MOUSE Cach3 Cacn4 Cacnl1a2 Cchl1a2 ENSMUST00000112250.1 ENSMUST00000112250.2 ENSMUST00000112250.3 ENSMUST00000112250.4 ENSMUST00000112250.5 NM_028981 Q7TSD2 Q8R2I9 Q8R2J0 Q99246 uc007sux.1 uc007sux.2 uc007sux.3 uc007sux.4 This gene encodes a pore-forming subunit of the L-type, voltage-activated calcium channel family. These channels have been found to play a role in heart and smooth muscle contraction and in the transmission of auditory information. Homozygous knockout mice for this gene exhibit deafness and heart defects. These channels have also been linked to mitochondrial oxidative stress in a mouse model of Parkinson's disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts (via IQ domain) with CABP1 and CABP4 in a calcium independent manner. Interacts with RIMBP2 (By similarity). Membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99246-2; Sequence=Displayed; Name=2; Synonyms=Cav1.3(1a); IsoId=Q99246-3; Sequence=VSP_027091, VSP_027092; Name=3; Synonyms=Cav1.3(1b); IsoId=Q99246-4; Sequence=VSP_027090, VSP_027091, VSP_027092; Expressed in the inner hair cells (IHC) of the cochlea. Isoform 2 and isoform 3 are expressed in heart at 12.5 dpc (at protein level). Expressed in the heart at 9.5, 12.5 and 15.5 dpc. Isoform 2 and isoform 3 are expressed in heart at 9.5 and 12.5 dpc. Up-regulated in CACNA1C knockout mice. Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage- sensor and are characterized by a series of positively charged amino acids at every third position. deafness, bradycardia and diabetic traits. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. ion channel activity voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity protein binding nucleus cytoplasm plasma membrane integral component of plasma membrane voltage-gated calcium channel complex ion transport calcium ion transport adenylate cyclase-modulating G-protein coupled receptor signaling pathway sensory perception of sound high voltage-gated calcium channel activity cell surface membrane integral component of membrane apical plasma membrane calcium-mediated signaling Z disc PDZ domain binding dendrite ankyrin binding dendrite membrane positive regulation of CREB transcription factor activity regulation of ion transmembrane transport positive regulation of insulin secretion involved in cellular response to glucose stimulus sarcolemma neuronal cell body positive regulation of adenylate cyclase activity metal ion binding alpha-actinin binding regulation of calcium ion transport positive regulation of calcium ion transport transmembrane transport regulation of atrial cardiac muscle cell membrane repolarization cardiac conduction calcium ion import calcium ion transmembrane transport divalent metal ion transport cardiac muscle cell action potential involved in contraction membrane depolarization during SA node cell action potential voltage-gated calcium channel activity involved SA node cell action potential regulation of heart rate by cardiac conduction integral component of presynaptic active zone membrane positive regulation of presynaptic cytosolic calcium concentration voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration regulation of potassium ion transmembrane transporter activity regulation of potassium ion transmembrane transport positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel L-type voltage-gated calcium channel complex uc007sux.1 uc007sux.2 uc007sux.3 uc007sux.4 
ENSMUST00000112254.8 Vwf ENSMUST00000112254.8 Von Willebrand factor (from RefSeq NM_011708.4) E9QPU1 E9QPU1_MOUSE ENSMUST00000112254.1 ENSMUST00000112254.2 ENSMUST00000112254.3 ENSMUST00000112254.4 ENSMUST00000112254.5 ENSMUST00000112254.6 ENSMUST00000112254.7 NM_011708 Vwf uc009dus.1 uc009dus.2 uc009dus.3 Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Multimeric. Interacts with F8. Secreted, extracellular space, extracellular matrix Secreted Note=Localized to storage granules. protease binding integrin binding collagen binding extracellular region endoplasmic reticulum cell adhesion blood coagulation hemostasis immunoglobulin binding platelet activation cell-substrate adhesion Weibel-Palade body identical protein binding protein homodimerization activity protein N-terminus binding chaperone binding protein homooligomerization uc009dus.1 uc009dus.2 uc009dus.3 
ENSMUST00000112265.9 Bmx ENSMUST00000112265.9 BMX non-receptor tyrosine kinase (from RefSeq NM_009759.4) B1AUL6 B1AUL6_MOUSE Bmx ENSMUST00000112265.1 ENSMUST00000112265.2 ENSMUST00000112265.3 ENSMUST00000112265.4 ENSMUST00000112265.5 ENSMUST00000112265.6 ENSMUST00000112265.7 ENSMUST00000112265.8 NM_009759 uc009uvj.1 uc009uvj.2 uc009uvj.3 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Cytoplasm Belongs to the protein kinase superfamily. Tyr protein kinase family. nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity ATP binding nucleoplasm plasma membrane protein phosphorylation signal transduction kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation ruffle membrane intracellular signal transduction protein autophosphorylation uc009uvj.1 uc009uvj.2 uc009uvj.3 
ENSMUST00000112268.4 Selenok ENSMUST00000112268.4 selenoprotein K (from RefSeq NM_019979.2) ENSMUST00000112268.1 ENSMUST00000112268.2 ENSMUST00000112268.3 NM_019979 Q8CI00 Q9JLJ1 SELK_MOUSE Selenok Selk uc007sul.1 uc007sul.2 uc007sul.3 The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Multiple pseudogenes of this locus have been identified. [provided by RefSeq, Sep 2017]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF170920.1, SRR1660813.185414.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 12775843 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (PubMed:21220695). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (PubMed:23444136). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (By similarity). Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity). Interacts with DERL1, DERL2, DERL3 and SELENOS (PubMed:22016385). The SELENOK-SELENOS complex interacts with VCP (By similarity). Interacts with ZDHHC6 (PubMed:25368151). Endoplasmic reticulum membrane ; Single-pass membrane protein Cell membrane ; Single- pass membrane protein Note=Probably mainly localized in the ER. High expression in spleen and intestine (at protein level). Expressed in a range of immune cells including T and B-cells and also in myeloid cells including macrophages, neutrophils and dendritic cells (at protein level). By increased dietary selenium. Expression is significantly decreased by a low selenium diet. Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity. Truncated SELENOK proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC2) complex, which recognizes the diglycine (Gly-Gly) at the C-terminus of truncated SELENOK proteins. Normal growth, fertility and immune system development. Reduced receptor-mediated Ca(2+) flux in T-cells, neutrophils and macrophages. Reduced T-cell proliferation and reduced T-cell and neutrophil migration. Decreased viral clearance and increased mortality following infection with West Nile virus. Bone marrow-derived macrophages from knockout mice display decreased uptake of acetylated or oxidized low-density lipoprotein, reduced foam cell formation and decreased palmitoylation and cell surface expression of CD36. Belongs to the selenoprotein K family. Sequence=AAF27311.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; positive regulation of defense response to virus by host endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane ion transport calcium ion transport response to oxidative stress macrophage derived foam cell differentiation membrane integral component of membrane protein palmitoylation positive regulation of cell migration endoplasmic reticulum calcium ion homeostasis positive regulation of tumor necrosis factor production positive regulation of T cell proliferation identical protein binding respiratory burst after phagocytosis regulation of calcium-mediated signaling regulation of protein transport intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of monocyte chemotactic protein-1 production positive regulation of chemokine secretion positive regulation of T cell migration positive regulation of interleukin-6 secretion regulation of store-operated calcium entry uc007sul.1 uc007sul.2 uc007sul.3 
ENSMUST00000112271.10 Ace2 ENSMUST00000112271.10 angiotensin converting enzyme 2, transcript variant 1 (from RefSeq NM_001130513.1) ACE2_MOUSE ENSMUST00000112271.1 ENSMUST00000112271.2 ENSMUST00000112271.3 ENSMUST00000112271.4 ENSMUST00000112271.5 ENSMUST00000112271.6 ENSMUST00000112271.7 ENSMUST00000112271.8 ENSMUST00000112271.9 NM_001130513 Q8R0I0 Q99N70 Q99N71 uc009uvf.1 uc009uvf.2 uc009uvf.3 uc009uvf.4 Essential counter-regulatory carboxypeptidase of the renin- angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A (By similarity). By cleavage of angiotensin II, may be an important regulator of heart function (PubMed:12075344, PubMed:12967627). By cleavage of angiotensin II, may also have a protective role in acute lung injury (PubMed:16001071). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19, regulating its trafficking on the cell surface and its activity (PubMed:19185582, PubMed:18424768, PubMed:22677001). Reaction=angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine; Xref=Rhea:RHEA:26554, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:58506, ChEBI:CHEBI:58922; EC=3.4.17.23; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26555; Evidence=; Reaction=angiotensin I + H2O = angiotensin-(1-9) + L-leucine; Xref=Rhea:RHEA:63532, ChEBI:CHEBI:15377, ChEBI:CHEBI:57427, ChEBI:CHEBI:147350, ChEBI:CHEBI:147351; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63533; Evidence=; Reaction=bradykinin(1-8) + H2O = bradykinin(1-7) + L-phenylalanine; Xref=Rhea:RHEA:63536, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:133069, ChEBI:CHEBI:147352; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63537; Evidence=; Reaction=H2O + neurotensin = L-leucine + neurotensin-(1-12); Xref=Rhea:RHEA:63540, ChEBI:CHEBI:15377, ChEBI:CHEBI:57427, ChEBI:CHEBI:147362, ChEBI:CHEBI:147363; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63541; Evidence=; Reaction=H2O + kinetensin = kinetensin-(1-8) + L-leucine; Xref=Rhea:RHEA:63544, ChEBI:CHEBI:15377, ChEBI:CHEBI:57427, ChEBI:CHEBI:147364, ChEBI:CHEBI:147365; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63545; Evidence=; Reaction=dynorphin A-(1-13) + H2O = dynorphin A-(1-12) + L-lysine; Xref=Rhea:RHEA:63556, ChEBI:CHEBI:15377, ChEBI:CHEBI:32551, ChEBI:CHEBI:147381, ChEBI:CHEBI:147383; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63557; Evidence=; Reaction=apelin-13 + H2O = apelin-12 + L-phenylalanine; Xref=Rhea:RHEA:63564, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:147395, ChEBI:CHEBI:147396; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63565; Evidence=; Reaction=[Pyr1]apelin-13 + H2O = [Pyr1]apelin-12 + L-phenylalanine; Xref=Rhea:RHEA:63604, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:147415, ChEBI:CHEBI:147416; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63605; Evidence=; Reaction=apelin-17 + H2O = apelin-16 + L-phenylalanine; Xref=Rhea:RHEA:63608, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:147421, ChEBI:CHEBI:147422; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63609; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence=; Note=Binds 1 Cl(-) ion per subunit. ; Homodimer. Interacts with the catalytically active form of TMPRSS2 (By similarity). Interacts with SLC6A19; this interaction is essential for expression and function of SLC6A19 in intestine (PubMed:19185582). Interacts with ITGA5:ITGB1 (By similarity). Probably interacts (via endocytic sorting signal motif) with AP2M1; the interaction is inhibited by phosphorylation of Tyr-781 (By similarity). Interacts (via PDZ-binding motif) with NHERF1 (via PDZ domains); the interaction may enhance ACE2 membrane residence (By similarity). (Microbial infection) Weakly interacts with SARS-CoV S protein. Q8R0I0; A0A6G6A1M4: S; Xeno; NbExp=2; IntAct=EBI-8365920, EBI-26997256; Q8R0I0; A0A6M3G9R1: S; Xeno; NbExp=2; IntAct=EBI-8365920, EBI-26997195; Q8R0I0; P0DTC2: S; Xeno; NbExp=4; IntAct=EBI-8365920, EBI-25474821; [Processed angiotensin-converting enzyme 2]: Secreted Cell membrane ; Single-pass type I membrane protein Cytoplasm Cell projection, cilium Apical cell membrane Note=Detected in both cell membrane and cytoplasm in neurons. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R0I0-1; Sequence=Displayed; Name=2; IsoId=Q8R0I0-2; Sequence=VSP_014903; Expressed in heart, kidney and forebrain (at protein level). Expressed in the small intestine, with expression in the intestinal brush border (at protein level) (PubMed:19185582, PubMed:22677001). Ubiquitously expressed, with highest levels in ileum, kidney and lung. In lung, expressed on vascular endothelial and airway epithelial cells. Also expressed at high levels in lung secretory club and goblet cells as well as in alveolar type 2 cells (PubMed:32425701). Down-regulated in lung after acute injury. Exposure to cigarette smoke increases ACE2 expression up to 80% more in lungs (PubMed:32425701). The cytoplasmic tail contains several linear motifs such as LIR, PDZ-binding, PTB and endocytic sorting signal motifs that would allow interaction with proteins that mediate endocytic trafficking and autophagy. Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1 (By similarity). Phosphorylated. Phosphorylation at Tyr-781 probably inhibits interaction with AP2M1 and enables interactions with proteins containing SH2 domains. Mice are viable and fertile, exhibit normal kidney and lung function, but show a severe reduction in cardiac contractility, and are highly sensitive to severe acute lung failure (PubMed:12075344). Mutant males exhibit an absence of SLC6A19 in small intestine brush border membranes, but normal SLC6A19 expression in kidney (PubMed:19185582). Abolished sodium-dependent transport of isoleucine in intestinal rings (PubMed:19185582). Transgenic mice overexpressing ACE2 in the heart appear healthy but show conduction disturbances and ventricular arrhythmias which leads to sudden death (PubMed:12075344). Belongs to the peptidase M2 family. Sequence=BAB40431.1; Type=Frameshift; Evidence=; virus receptor activity angiotensin-mediated drinking behavior regulation of systemic arterial blood pressure by renin-angiotensin endopeptidase activity carboxypeptidase activity metallocarboxypeptidase activity protein binding extracellular region extracellular space cytoplasm plasma membrane proteolysis peptidase activity metallopeptidase activity exopeptidase activity dipeptidyl-peptidase activity peptidyl-dipeptidase activity cell surface tryptophan transport membrane integral component of membrane hydrolase activity brush border membrane receptor biosynthetic process viral entry into host cell receptor-mediated virion attachment to host cell metal ion binding negative regulation of smooth muscle cell proliferation positive regulation of amino acid transport positive regulation of cardiac muscle contraction negative regulation of ERK1 and ERK2 cascade positive regulation of gap junction assembly regulation of cardiac conduction uc009uvf.1 uc009uvf.2 uc009uvf.3 uc009uvf.4 
ENSMUST00000112279.2 Alkbh2 ENSMUST00000112279.2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase, transcript variant 8 (from RefSeq NR_188821.1) ALKB2_MOUSE Abh2 ENSMUST00000112279.1 NR_188821 Q6P6J4 Q8C591 uc008yze.1 uc008yze.2 uc008yze.3 Dioxygenase that repairs alkylated nucleic acid bases by direct reversal oxidative dealkylation. Can process both double- stranded (ds) and single-stranded (ss) DNA substrates, with a strong preference for dsDNA (PubMed:16174769, PubMed:16642038, PubMed:18519673). Uses molecular oxygen, 2-oxoglutarate and iron as cofactors to oxidize the alkyl groups that are subsequently released as aldehydes, regenerating the undamaged bases. Probes the base pair stability, locates a weakened base pair and flips the damaged base to accommodate the lesion in its active site for efficient catalysis (PubMed:16174769, PubMed:16642038, PubMed:18519673) (By similarity). Repairs monoalkylated bases, specifically N1-methyladenine and N3- methylcytosine, as well as higher order alkyl adducts such as bases modified with exocyclic bridged adducts known as etheno adducts including 1,N6-ethenoadenine, 3,N4-ethenocytosine and 1,N2- ethenoguanine (By similarity). Acts as a gatekeeper of genomic integrity under alkylation stress. Efficiently repairs alkylated lesions in ribosomal DNA (rDNA). These lesions can cause ss- and dsDNA strand breaks that severely impair rDNA transcription (By similarity). In a response mechanism to DNA damage, associates with PCNA at replication forks to repair alkylated adducts prior to replication (By similarity). Reaction=2-oxoglutarate + a methylated nucleobase within DNA + O2 = a nucleobase within DNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:30299, Rhea:RHEA-COMP:12192, Rhea:RHEA-COMP:12193, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:32875, ChEBI:CHEBI:64428; EC=1.14.11.33; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30300; Evidence= Reaction=2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double- stranded DNA + O2 = a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate; Xref=Rhea:RHEA:70443, Rhea:RHEA- COMP:14236, Rhea:RHEA-COMP:17897, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:90615, ChEBI:CHEBI:139096; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70444; Evidence=; Reaction=2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single- stranded DNA + O2 = a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate; Xref=Rhea:RHEA:70447, Rhea:RHEA- COMP:17895, Rhea:RHEA-COMP:17896, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:90615, ChEBI:CHEBI:139096; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70448; Evidence=; Reaction=2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double- stranded DNA + O2 = a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate; Xref=Rhea:RHEA:70439, Rhea:RHEA- COMP:14237, Rhea:RHEA-COMP:17070, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:85452, ChEBI:CHEBI:139075; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70440; Evidence=; Reaction=2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single- stranded DNA + O2 = a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate; Xref=Rhea:RHEA:70435, Rhea:RHEA- COMP:12846, Rhea:RHEA-COMP:17894, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:85452, ChEBI:CHEBI:139075; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70436; Evidence=; Reaction=2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double- stranded DNA + H2O + O2 = a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate; Xref=Rhea:RHEA:70463, Rhea:RHEA- COMP:17897, Rhea:RHEA-COMP:17903, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:34779, ChEBI:CHEBI:90615, ChEBI:CHEBI:189583; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70464; Evidence=; Reaction=2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single- stranded DNA + H2O + O2 = a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate; Xref=Rhea:RHEA:70459, Rhea:RHEA- COMP:17896, Rhea:RHEA-COMP:17904, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:34779, ChEBI:CHEBI:90615, ChEBI:CHEBI:189583; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70460; Evidence=; Reaction=2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double- stranded DNA + H2O + O2 = a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate; Xref=Rhea:RHEA:70467, Rhea:RHEA- COMP:17070, Rhea:RHEA-COMP:17905, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:34779, ChEBI:CHEBI:85452, ChEBI:CHEBI:189585; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70468; Evidence=; Reaction=2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single- stranded DNA + H2O + O2 = a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate; Xref=Rhea:RHEA:70471, Rhea:RHEA- COMP:12846, Rhea:RHEA-COMP:17906, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:34779, ChEBI:CHEBI:85452, ChEBI:CHEBI:189585; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70472; Evidence=; Reaction=2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double- stranded DNA + H2O + O2 = a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate; Xref=Rhea:RHEA:70487, Rhea:RHEA- COMP:17910, Rhea:RHEA-COMP:17912, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:34779, ChEBI:CHEBI:85445, ChEBI:CHEBI:189586; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70488; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence= Note=Binds 1 Fe(2+) ion per subunit. ; Activated by magnesium ions. Interacts with PCNA homotrimer; this interaction is enhanced during the S-phase of the cell cycle. Interacts with nucleolar proteins NCL, UBTF and NPM1. Interacts with XRCC5-XRCC6 heterodimer. Nucleus cleus, nucleolus Nucleus, nucleoplasm Note=Relocates to the replication foci during S-phase. Detected in liver, testis and kidney (at protein level). Detected in heart and testis. The PCNA-binding motif (AlkB homolog 2 PCNA-interacting motif, APIM), mediates the colocalization of ALKBH2 with PCNA at the replication foci, coordinating the repair of alkylated DNA damage with DNA replication. No visible phenotype, and no effect on the level of 1-ethenoadenine in genomic DNA in aging mice. In contrast, the levels of 1-methyladenine in genomic DNA increase over time in aging adults. Belongs to the alkB family. nucleus nucleoplasm DNA repair DNA dealkylation involved in DNA repair cellular response to DNA damage stimulus ferrous iron binding microtubule cytoskeleton oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors oxidative DNA demethylation DNA-N1-methyladenine dioxygenase activity metal ion binding dioxygenase activity cytosine C-5 DNA demethylase activity oxidation-reduction process nucleic acid phosphodiester bond hydrolysis 1-ethyladenine demethylase activity endonuclease activity exonuclease activity uc008yze.1 uc008yze.2 uc008yze.3 
ENSMUST00000112280.8 Cltrn ENSMUST00000112280.8 Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity (PubMed:17167413, PubMed:16985211). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (PubMed:16985211). Regulator of SNARE complex function (PubMed:16330323). Stimulator of beta cell replication (PubMed:16330324). (from UniProt Q9ESG4) AF178085 CLTRN_MOUSE Cltrn ENSMUST00000112280.1 ENSMUST00000112280.2 ENSMUST00000112280.3 ENSMUST00000112280.4 ENSMUST00000112280.5 ENSMUST00000112280.6 ENSMUST00000112280.7 Nx17 Q3UFF6 Q9ESG4 Tmem27 uc292rqu.1 uc292rqu.2 Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity (PubMed:17167413, PubMed:16985211). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (PubMed:16985211). Regulator of SNARE complex function (PubMed:16330323). Stimulator of beta cell replication (PubMed:16330324). Monomer (PubMed:16330324). Homodimer (PubMed:16330324). Homodimer; dimerization prevents CLTRN cleavage by BACE2 (PubMed:16330324). Interacts with SNAPIN (PubMed:16330323). Interacts with SLC6A18; this interaction regulates the trafficking of SLC6A18 to the cell membrane and its amino acid transporter activity (PubMed:17167413, PubMed:19478081). Interacts with SLC6A19; this interaction regulates the trafficking of SLC6A19 to the cell membrane and its amino acid transporter activity (PubMed:17167413). Interacts with SLC6A20B (PubMed:17167413). Cell membrane ingle-pass type I membrane protein Note=Localizes to the brush border membranes of cells in the proximal tubules of kidney (PubMed:17167413). Colocalizes with SLC6A19 in the early proximal S1 tubule (PubMed:17167413). Expressed on the apical surface of the proximal tubules in the renal cortex (at protein level) (PubMed:16985211). Kidney; collecting ducts and proximal tubule (PubMed:11278314, PubMed:17167413, PubMed:16985211). Pancreas; beta cells of islets (PubMed:16330323, PubMed:16330324). Expressed in the cerebral cortex, hippocampus, brainstem and cerebellum (PubMed:31520464). Up-regulated by high glucose concentration in beta-cells (at protein level). The cleavage site containing the double Phe-Phe motif acts as negative regulator of shedding by BACE2. Glycosylated. Glycosylation is required for plasma membrane localization and for its cleavage by BACE2. Proteolytically processed in pancreatic beta cells by BACE2 leading to the generation and extracellular release of soluble CLTRN, and a corresponding cell-associated C-terminal fragment which is later cleaved by gamma-secretase (PubMed:16330324, PubMed:21907142). This shedding process inactivates CLTRN (PubMed:16330324). Three cleavage sites have been identified for BACE2, two clustered sites after Phe-116 and Leu-118 and a more membrane proximal site at Phe-125; the preferred BACE2 cleavage site seems to be between Phe-125 and Leu-126, Phe-116 and Leu-118 act as alternative sites (By similarity). Deficient mice are viable and fertile but exhibit a severe defect in renal amino acid uptake due to down-regulation of apical amino acid transporters in the kidney (PubMed:17167413). Greater urine output, more dilute urine, a defect in urinary concentration, higher osmolar clearance and an increase in free water absorption, suggesting an osmotic diuresis (PubMed:16985211). Decreased urine osmolytes sodium and urea, presence of tyrosine and glutamine crystals in the urine, and increased excretion of amino acids in the urine, suggesting an aminoaciduria (PubMed:16985211). Decreased population of amino acid transporters SLC6A19, SLC3A1 and SLC7A9 in the renal cortical cell membrane (PubMed:16985211). Increased intracellular SLC1A1 levels (PubMed:16985211). Belongs to the CLTRN family. protein binding cytoplasm plasma membrane membrane integral component of membrane brush border membrane positive regulation of SNARE complex assembly positive regulation of insulin secretion involved in cellular response to glucose stimulus protein homodimerization activity positive regulation of calcium ion-dependent exocytosis positive regulation of amino acid transport uc292rqu.1 uc292rqu.2 
ENSMUST00000112289.9 Zrsr2 ENSMUST00000112289.9 zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, transcript variant 1 (from RefSeq NM_009453.4) B1B0E8 B1B0E8_MOUSE ENSMUST00000112289.1 ENSMUST00000112289.2 ENSMUST00000112289.3 ENSMUST00000112289.4 ENSMUST00000112289.5 ENSMUST00000112289.6 ENSMUST00000112289.7 ENSMUST00000112289.8 NM_009453 Zrsr2 uc009uuz.1 uc009uuz.2 uc009uuz.3 uc009uuz.4 mRNA splicing, via spliceosome nucleic acid binding RNA binding metal ion binding U2AF uc009uuz.1 uc009uuz.2 uc009uuz.3 uc009uuz.4 
ENSMUST00000112292.9 Dao ENSMUST00000112292.9 D-amino acid oxidase, transcript variant 1 (from RefSeq NM_010018.3) A0A0R4J203 A0A0R4J203_MOUSE Dao ENSMUST00000112292.1 ENSMUST00000112292.2 ENSMUST00000112292.3 ENSMUST00000112292.4 ENSMUST00000112292.5 ENSMUST00000112292.6 ENSMUST00000112292.7 ENSMUST00000112292.8 NM_010018 uc008yza.1 uc008yza.2 uc008yza.3 uc008yza.4 uc008yza.5 Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. Reaction=a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+); Xref=Rhea:RHEA:21816, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:35179, ChEBI:CHEBI:59871; EC=1.4.3.3; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Peroxisome Belongs to the DAMOX/DASOX family. D-amino-acid oxidase activity mitochondrial outer membrane peroxisome peroxisomal membrane cytosol proline catabolic process oxidoreductase activity D-serine catabolic process dopamine biosynthetic process D-amino acid metabolic process protein dimerization activity cofactor binding oxidation-reduction process D-alanine catabolic process D-serine metabolic process FAD binding uc008yza.1 uc008yza.2 uc008yza.3 uc008yza.4 uc008yza.5 
ENSMUST00000112295.9 Gmppb ENSMUST00000112295.9 GDP-mannose pyrophosphorylase B, transcript variant 3 (from RefSeq NM_001410629.1) ENSMUST00000112295.1 ENSMUST00000112295.2 ENSMUST00000112295.3 ENSMUST00000112295.4 ENSMUST00000112295.5 ENSMUST00000112295.6 ENSMUST00000112295.7 ENSMUST00000112295.8 GMPPB_MOUSE Gmppb NM_001410629 Q8BTZ7 uc009rog.1 uc009rog.2 uc009rog.3 Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP- alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527, ChEBI:CHEBI:58409; EC=2.7.7.13; Evidence=; Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1. Associates with GMPPA. Cytoplasm Belongs to the transferase hexapeptide repeat family. nucleotide binding mannose-1-phosphate guanylyltransferase activity GTP binding cytoplasm mitochondrion biosynthetic process GDP-mannose biosynthetic process transferase activity nucleotidyltransferase activity uc009rog.1 uc009rog.2 uc009rog.3 
ENSMUST00000112308.9 Lrpprc ENSMUST00000112308.9 leucine-rich PPR-motif containing (from RefSeq NM_028233.2) ENSMUST00000112308.1 ENSMUST00000112308.2 ENSMUST00000112308.3 ENSMUST00000112308.4 ENSMUST00000112308.5 ENSMUST00000112308.6 ENSMUST00000112308.7 ENSMUST00000112308.8 LPPRC_MOUSE Lrp130 NM_028233 Q6PB66 Q8K4V0 Q9CRX4 uc008dtc.1 uc008dtc.2 uc008dtc.3 May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (By similarity). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (By similarity). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters (By similarity). Binds single-stranded DNA. Interacts with CECR2, HEBP2, MAP1S and UXT (By similarity). Interacts with PPARGC1A (By similarity). Interacts with FOXO1. Component of mRNP complexes associated with HNRPA1 (By similarity). Interacts (via N-terminus) with EIF4E; the interaction promotes association of EIF4E with 4ESE-containing mRNAs (PubMed:19262567, PubMed:28325843). Interacts with exportin XPO1/CRM1; interacts both alone and in complex with EIF4E and 4ESE-containing mRNAs to form an EIF4E-dependent mRNA export complex (By similarity). Interacts with importin IPO8; the interaction occurs when LRPPRC is in its RNA-free form and returns LRPPRC to the nucleus for further export rounds (By similarity). Q6PB66; Q9R1E0: Foxo1; NbExp=2; IntAct=EBI-1371262, EBI-1371343; Q6PB66; O70343: Ppargc1a; NbExp=2; IntAct=EBI-1371262, EBI-1371053; Mitochondrion Nucleus Nucleus, nucleoplasm Nucleus inner membrane Nucleus outer membrane Strongly expressed in heart, liver and kidney. Weakly expressed in brain, skeletal muscle and testes. Expressed at embryonic stages 7 dpc, 11 dpc, 15 dpc and 17 dpc with a slight increase of levels during development. Sequence=AAH59862.1; Type=Erroneous initiation; Evidence=; Sequence=BAB29082.2; Type=Erroneous translation; Note=CTG leucine codon is translated as initiator methionine.; Evidence=; condensed nuclear chromosome negative regulation of mitochondrial RNA catabolic process DNA binding single-stranded DNA binding RNA binding protein binding nucleus nuclear inner membrane nuclear outer membrane nucleoplasm cytoplasm mitochondrion cytoskeleton microtubule membrane ubiquitin protein ligase binding mitochondrial nucleoid perinuclear region of cytoplasm beta-tubulin binding mRNA transport regulation of mitochondrial translation ribonucleoprotein complex actin filament binding uc008dtc.1 uc008dtc.2 uc008dtc.3 
ENSMUST00000112335.4 Rbp4 ENSMUST00000112335.4 retinol binding protein 4, plasma, transcript variant 2 (from RefSeq NM_011255.3) ENSMUST00000112335.1 ENSMUST00000112335.2 ENSMUST00000112335.3 NM_011255 P70357 Q00724 Q566I5 RET4_MOUSE uc008hjd.1 uc008hjd.2 uc008hjd.3 uc008hjd.4 Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6. Secreted Belongs to the calycin superfamily. Lipocalin family. eye development retinoid binding protein binding extracellular region extracellular space gluconeogenesis spermatogenesis heart development male gonad development retinal binding retinol binding maintenance of gastrointestinal epithelium lung development positive regulation of insulin secretion response to retinoic acid response to insulin macromolecular complex retinol transporter activity retinol transport retinol metabolic process retinal metabolic process glucose homeostasis protein heterodimerization activity embryonic organ morphogenesis embryonic skeletal system development cardiac muscle tissue development female genitalia morphogenesis detection of light stimulus involved in visual perception positive regulation of immunoglobulin secretion retina development in camera-type eye negative regulation of cardiac muscle cell proliferation embryonic retina morphogenesis in camera-type eye uterus development vagina development urinary bladder development heart trabecula formation vitamin A import uc008hjd.1 uc008hjd.2 uc008hjd.3 uc008hjd.4 
ENSMUST00000112336.8 Crybb2 ENSMUST00000112336.8 crystallin, beta B2 (from RefSeq NM_007773.4) CRBB2_MOUSE ENSMUST00000112336.1 ENSMUST00000112336.2 ENSMUST00000112336.3 ENSMUST00000112336.4 ENSMUST00000112336.5 ENSMUST00000112336.6 ENSMUST00000112336.7 NM_007773 P19942 P26775 P62696 Q0VGT6 uc008ytx.1 uc008ytx.2 uc008ytx.3 This gene is a member of the beta-crystallin family. Beta crystallins, along with alpha and gamma crystallins, are the major proteins found in the eye lens. These proteins maintain the refractive index of the lens whilst also maintaining its transparency. Since lens central fiber cells lose their nuclei during development, crystallins are made and then retained throughout life, making them extremely stable proteins. Beta and gamma crystallins are considered be a superfamily and have a similar domain architecture, including four Greek Key motifs. Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. The protein encoded by this gene may have Ca2+-binding activity and could be associated with potential functions in the hippocampus and in sperm. Targeted knockout of this gene in mouse induces age-related cataract. A chain-terminating mutation in a similar gene in human was found to cause type 2 cerulean cataracts. [provided by RefSeq, Feb 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085185.1, CO427954.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849377 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## Crystallins are the dominant structural components of the vertebrate eye lens. Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity). Has a two-domain beta-structure, folded into four very similar Greek key motifs. Belongs to the beta/gamma-crystallin family. lens development in camera-type eye structural constituent of eye lens visual perception identical protein binding protein homodimerization activity camera-type eye development uc008ytx.1 uc008ytx.2 uc008ytx.3 
ENSMUST00000112338.2 Rai2 ENSMUST00000112338.2 retinoic acid induced 2, transcript variant 2 (from RefSeq NM_001103367.1) ENSMUST00000112338.1 NM_001103367 Q3UPL8 Q9QVY8 RAI2_MOUSE uc009uua.1 uc009uua.2 uc009uua.3 uc009uua.4 By retinoic acid. molecular_function cellular_component biological_process uc009uua.1 uc009uua.2 uc009uua.3 uc009uua.4 
ENSMUST00000112349.9 Mta3 ENSMUST00000112349.9 metastasis associated 3, transcript variant 3 (from RefSeq NM_001171053.1) E9Q794 E9Q794_MOUSE ENSMUST00000112349.1 ENSMUST00000112349.2 ENSMUST00000112349.3 ENSMUST00000112349.4 ENSMUST00000112349.5 ENSMUST00000112349.6 ENSMUST00000112349.7 ENSMUST00000112349.8 Mta3 NM_001171053 uc008dsf.1 uc008dsf.2 uc008dsf.3 uc008dsf.4 DNA binding chromatin binding nucleus regulation of transcription, DNA-templated zinc ion binding sequence-specific DNA binding uc008dsf.1 uc008dsf.2 uc008dsf.3 uc008dsf.4 
ENSMUST00000112357.9 Lemd1 ENSMUST00000112357.9 LEM domain containing 1, transcript variant 4 (from RefSeq NM_001033250.4) ENSMUST00000112357.1 ENSMUST00000112357.2 ENSMUST00000112357.3 ENSMUST00000112357.4 ENSMUST00000112357.5 ENSMUST00000112357.6 ENSMUST00000112357.7 ENSMUST00000112357.8 LEMD1_MOUSE NM_001033250 Q14C37 uc007coj.1 uc007coj.2 uc007coj.3 uc007coj.4 molecular_function cellular_component biological_process uc007coj.1 uc007coj.2 uc007coj.3 uc007coj.4 
ENSMUST00000112359.9 Hps4 ENSMUST00000112359.9 HPS4, biogenesis of lysosomal organelles complex 3 subunit 2, transcript variant 1 (from RefSeq NM_001359853.1) ENSMUST00000112359.1 ENSMUST00000112359.2 ENSMUST00000112359.3 ENSMUST00000112359.4 ENSMUST00000112359.5 ENSMUST00000112359.6 ENSMUST00000112359.7 ENSMUST00000112359.8 HPS4_MOUSE Le NM_001359853 Q99KG7 uc008ytc.1 uc008ytc.2 uc008ytc.3 uc008ytc.4 Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38. Component of the biogenesis of lysosome-related organelles complex-3 (or BLOC-3), a heterodimer of HPS1 and HPS4. HPS4 and the BLOC-3 complex interact with the GTP-bound form of RAB9B but not with the GDP-bound form of RAB9B (By similarity). HPS4 and the BLOC-3 complex interact with the GTP-bound form of RAB9A but not with the GDP- bound form of RAB9A (PubMed:20048159, PubMed:26620560). HPS4 does not interact RAB4A and RAB7A (PubMed:26620560). Highly expressed in heart, brain, liver and testis. Expressed at lower level in skeletal muscle. Note=Defects in Hps4 are the cause of the light ear (le) mutant which exhibits hypopigmentation associated with defects of multiple cytoplasmic organelles, including melanosomes, lysosomes, and granular elements of platelets (PubMed:11836498). guanyl-nucleotide exchange factor activity cytoplasm lysosome protein targeting organelle organization lysosome organization blood coagulation membrane Rab GTPase binding melanocyte differentiation BLOC-3 complex cytoplasmic vesicle melanosome protein homodimerization activity platelet dense granule protein dimerization activity protein stabilization melanosome assembly uc008ytc.1 uc008ytc.2 uc008ytc.3 uc008ytc.4 
ENSMUST00000112366.8 Scn1a ENSMUST00000112366.8 sodium channel, voltage-gated, type I, alpha, transcript variant 1 (from RefSeq NM_001313997.1) A2APX6 A2APX7 A2APX8 ENSMUST00000112366.1 ENSMUST00000112366.2 ENSMUST00000112366.3 ENSMUST00000112366.4 ENSMUST00000112366.5 ENSMUST00000112366.6 ENSMUST00000112366.7 NM_001313997 Q68V28 SCN1A_MOUSE Scn1a uc289wno.1 uc289wno.2 Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:16921370, PubMed:17928448, PubMed:27281198). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons (PubMed:16921370, PubMed:22914087). Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli (PubMed:27281198). Reaction=Na(+)(in) = Na(+)(out); Xref=Rhea:RHEA:34963, ChEBI:CHEBI:29101; Evidence=; Inactivation of this channel is specifically inhibited by the spider toxins Hm1a and Hm1b (H.maculata, AC P60992 and AC P0DOC5) in somatosensory neurons to elicit acute pain and mechanical allodynia (PubMed:27281198). The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1 (SCN1B), beta-2 (SCN2B), beta-3 (SCN3B) and/or beta-4 (SCN4B). Beta-1 (SCN1B) and beta-3 (SCN3B) are non-covalently associated with alpha, while beta-2 (SCN2B) and beta-4 (SCN4B) are covalently linked by disulfide bonds. Interacts with FGF13. Interacts with TMEM233 (By similarity).Interacts with the conotoxin GVIIJ. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2APX8-1; Sequence=Displayed; Name=2; IsoId=A2APX8-2; Sequence=VSP_058553; Name=3; IsoId=A2APX8-3; Sequence=VSP_058552; Present in cerebellar Purkinje neurons (at protein level) (PubMed:17928448). Expressed by myelinated, non-C-fiber neurons in sensory ganglia (PubMed:27281198). The S3b-S4 and S1-S2 loops of repeat IV are targeted by H.maculata toxins Hm1a and Hm1b, leading to inhibit fast inactivation of Nav1.1/SCN1A. Selectivity for H.maculata toxins Hm1a and Hm1b depends on S1-S2 loops of repeat IV (PubMed:27281198). The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. Phosphorylation at Ser-1516 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. Homozygous mice display severe seizures and premature death on postnatal day 15 (PubMed:16921370). Mice show severe motor deficits, including irregularity of stride length during locomotion, impaired motor reflexes in grasping and mild tremor in limbs when immobile, consistent with cerebellar dysfunction (PubMed:16921370). Heterozygous mice exhibit autistic-like behavior, characterized by hyperactivity, stereotyped behaviors, social interaction deficits and impaired context-dependent spatial memory (PubMed:22914087). Defects are caused by caused by impaired GABAergic neurotransmission (PubMed:22914087). Conditional knockout in forebrain GABAergic neurons leads to premature death caused by generalized tonic- clonic seizures in heterozygous mice (PubMed:22908258). Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.1/SCN1A subfamily. action potential voltage-gated sodium channel complex ion channel activity voltage-gated ion channel activity voltage-gated sodium channel activity sodium channel activity nucleoplasm plasma membrane ion transport sodium ion transport adult walking behavior intercalated disc membrane integral component of membrane nuclear body neuronal action potential propagation neuronal action potential Z disc T-tubule axon sodium ion binding node of Ranvier sodium channel complex regulation of ion transmembrane transport sodium ion transmembrane transport regulation of membrane potential neuronal cell body axon initial segment neuromuscular process controlling posture detection of mechanical stimulus involved in sensory perception of pain transmembrane transport cardiac muscle cell action potential involved in contraction membrane depolarization during action potential integral component of presynaptic membrane uc289wno.1 uc289wno.2 
ENSMUST00000112377.8 Phka2 ENSMUST00000112377.8 phosphorylase kinase alpha 2, transcript variant 2 (from RefSeq NM_001177879.2) ENSMUST00000112377.1 ENSMUST00000112377.2 ENSMUST00000112377.3 ENSMUST00000112377.4 ENSMUST00000112377.5 ENSMUST00000112377.6 ENSMUST00000112377.7 KPB2_MOUSE NM_001177879 Q3TN65 Q810J6 Q8BWJ3 uc009utk.1 uc009utk.2 uc009utk.3 Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. By phosphorylation of various serine residues and by calcium. Glycan biosynthesis; glycogen metabolism. Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated. Belongs to the phosphorylase b kinase regulatory chain family. Sequence=AAH50040.1; Type=Erroneous initiation; Evidence=; catalytic activity calmodulin binding plasma membrane phosphorylase kinase complex carbohydrate metabolic process glycogen metabolic process protein phosphorylation membrane phosphorylase kinase activity uc009utk.1 uc009utk.2 uc009utk.3 
ENSMUST00000112385.8 Cryba4 ENSMUST00000112385.8 crystallin, beta A4, transcript variant 1 (from RefSeq NM_021351.2) CRBA4_MOUSE ENSMUST00000112385.1 ENSMUST00000112385.2 ENSMUST00000112385.3 ENSMUST00000112385.4 ENSMUST00000112385.5 ENSMUST00000112385.6 ENSMUST00000112385.7 NM_021351 Q9JJV0 uc008ysu.1 uc008ysu.2 uc008ysu.3 uc008ysu.4 This gene encodes a member of the crystallin family of proteins that contribute to the transparency and refractive properties of the ocular lens. Certain mutations in the human ortholog of this gene are associated with cataract and bilateral microphthalmia. This gene is located adjacent to a related crystallin gene on chromosome 5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]. Crystallins are the dominant structural components of the vertebrate eye lens. Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity). Has a two-domain beta-structure, folded into four very similar Greek key motifs. Belongs to the beta/gamma-crystallin family. lens development in camera-type eye structural constituent of eye lens visual perception camera-type eye development uc008ysu.1 uc008ysu.2 uc008ysu.3 uc008ysu.4 
ENSMUST00000112393.9 Pm20d1 ENSMUST00000112393.9 peptidase M20 domain containing 1, transcript variant 1 (from RefSeq NM_178079.3) ENSMUST00000112393.1 ENSMUST00000112393.2 ENSMUST00000112393.3 ENSMUST00000112393.4 ENSMUST00000112393.5 ENSMUST00000112393.6 ENSMUST00000112393.7 ENSMUST00000112393.8 NM_178079 P20D1_MOUSE Pm20d1 Q3UNX0 Q8C165 Q8R117 uc007cnt.1 uc007cnt.2 uc007cnt.3 uc007cnt.4 Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction (PubMed:27374330, PubMed:29533650, PubMed:29967167, PubMed:32271712, PubMed:32402239) (Probable). Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure (PubMed:27374330, PubMed:29967167, PubMed:32271712). PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles (PubMed:32402239). Reaction=an N-acyl-L-amino acid + H2O = a carboxylate + an L-alpha- amino acid; Xref=Rhea:RHEA:15565, ChEBI:CHEBI:15377, ChEBI:CHEBI:29067, ChEBI:CHEBI:59869, ChEBI:CHEBI:59874; EC=3.5.1.14; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15566; Evidence= PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:15567; Evidence=; Reaction=an N-acyl-aromatic L-alpha-amino acid + H2O = a carboxylate + an aromatic L-alpha-amino acid; Xref=Rhea:RHEA:54184, ChEBI:CHEBI:15377, ChEBI:CHEBI:29067, ChEBI:CHEBI:84824, ChEBI:CHEBI:138093; EC=3.5.1.114; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54185; Evidence= PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:54186; Evidence= Reaction=H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine; Xref=Rhea:RHEA:64108, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:57305, ChEBI:CHEBI:59002; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64109; Evidence= PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64110; Evidence=; Reaction=H2O + N-hexadecanoyl-L-phenylalanine = hexadecanoate + L- phenylalanine; Xref=Rhea:RHEA:64124, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:149699; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64125; Evidence=; Reaction=H2O + N-octadecanoyl-L-phenylalanine = L-phenylalanine + octadecanoate; Xref=Rhea:RHEA:64128, ChEBI:CHEBI:15377, ChEBI:CHEBI:25629, ChEBI:CHEBI:58095, ChEBI:CHEBI:149700; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64129; Evidence=; Reaction=H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L- phenylalanine = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L- phenylalanine; Xref=Rhea:RHEA:64132, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:77016, ChEBI:CHEBI:149701; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64133; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-L-asparagine = (9Z)-octadecenoate + L-asparagine; Xref=Rhea:RHEA:64136, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:58048, ChEBI:CHEBI:149730; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64137; Evidence=; Reaction=(9Z)-octadecenoate + glycine = H2O + N-(9Z- octadecenoyl)glycine; Xref=Rhea:RHEA:51316, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57305, ChEBI:CHEBI:133992; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:51318; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-L-lysine = (9Z)-octadecenoate + L- lysine; Xref=Rhea:RHEA:64192, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:32551, ChEBI:CHEBI:149731; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64193; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-L-methionine = (9Z)-octadecenoate + L-methionine; Xref=Rhea:RHEA:64144, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57844, ChEBI:CHEBI:149732; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64145; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-L-serine = (9Z)-octadecenoate + L- serine; Xref=Rhea:RHEA:51352, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:33384, ChEBI:CHEBI:134031; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51353; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-L-tryptophan = (9Z)-octadecenoate + L-tryptophan; Xref=Rhea:RHEA:64176, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57912, ChEBI:CHEBI:149733; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64177; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-L-tyrosine = (9Z)-octadecenoate + L- tyrosine; Xref=Rhea:RHEA:64184, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:58315, ChEBI:CHEBI:149734; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64185; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-L-glutamine = (9Z)-octadecenoate + L-glutamine; Xref=Rhea:RHEA:51356, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:58359, ChEBI:CHEBI:134033; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51357; Evidence=; Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine; Xref=Rhea:RHEA:64116, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:33384, ChEBI:CHEBI:149697; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64117; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64118; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = H2O + N- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine; Xref=Rhea:RHEA:51312, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:58095, ChEBI:CHEBI:134022; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51313; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:51314; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-L-leucine = (9Z)-octadecenoate + L- leucine; Xref=Rhea:RHEA:51360, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57427, ChEBI:CHEBI:134035; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51361; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:51362; Evidence=; Reaction=(9Z)-octadecenoate + L-phenylalanine = H2O + N-(9Z- octadecenoyl)-L-phenylalanine; Xref=Rhea:RHEA:51300, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:58095, ChEBI:CHEBI:134020; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51301; Evidence= PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:51302; Evidence= Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Lipoproteins are powerful coactivators of PM20D1 activity in vitro and NAA biosynthesis in vivo. Amino-acid metabolism. Energy metabolism; electron transfer. Lipid metabolism; fatty acid metabolism. Secreted In addition to being detected in blood (at protein level), PM20D1 is also highly expressed in other tissues including brown adipocytes, liver and kidney (PubMed:27374330, PubMed:29967167). It is also expressed in small intestine, large intestine, heart and pancreas (PubMed:29967167). Up-regulated in adipose tissue upon cold exposure. Genetic ablation causes tissue-specific bidirectional dysregulation of several N-acyl amino acids (PubMed:29967167, PubMed:32271712). Locomotor activity and resting energy requirements (RER) are slightly increased and decreased, respectively, in PM20D1-KO mice on chow diet, while diet-induced obesity conditions produce a marked impairment in glucose homeostasis and insulin sensitivity in these mice. They also exhibit enhanced defense of body temperature in cold, and antinociceptive behaviors selectively in response to chemical and inflammatory pain stimuli while maintaining normal thermal pain sensation and normal movement (PubMed:29967167). Overexpression in mice blunts high fat diet-induced increase in fat mass and associated weight gain (PubMed:27374330). Free NAAs represent the biologically active form of these circulating molecules, and the circulating NAAs bioactivity is determined by plasma protein binding (PubMed:32402239). Belongs to the peptidase M20A family. extracellular region extracellular space proteolysis cellular amino acid metabolic process nitrogen compound metabolic process peptidase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides lyase activity amide biosynthetic process cellular amide catabolic process cellular lipid metabolic process metal ion binding energy homeostasis negative regulation of neuron death adaptive thermogenesis regulation of oxidative phosphorylation uncoupler activity uc007cnt.1 uc007cnt.2 uc007cnt.3 uc007cnt.4 
ENSMUST00000112405.9 Adgrg2 ENSMUST00000112405.9 adhesion G protein-coupled receptor G2, transcript variant 5 (from RefSeq NM_001290445.1) A2AHP8 A2AHP9 A2AHQ0 A2AHQ3 AGRG2_MOUSE Adgrg2 ENSMUST00000112405.1 ENSMUST00000112405.2 ENSMUST00000112405.3 ENSMUST00000112405.4 ENSMUST00000112405.5 ENSMUST00000112405.6 ENSMUST00000112405.7 ENSMUST00000112405.8 Gpr64 Me6 NM_001290445 Q8BL10 Q8CJ08 Q8CJ09 Q8CJ10 Q8CJ12 uc009uti.1 uc009uti.2 uc009uti.3 uc009uti.4 Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis. Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C- terminal fragment predominantly remain associated and non-covalently linked. Apical cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Long; IsoId=Q8CJ12-1; Sequence=Displayed; Name=2; Synonyms=d2; IsoId=Q8CJ12-2; Sequence=VSP_009808; Name=3; Synonyms=d1; IsoId=Q8CJ12-3; Sequence=VSP_009809; Name=4; Synonyms=d3; IsoId=Q8CJ12-4; Sequence=VSP_009807; Name=5; IsoId=Q8CJ12-5; Sequence=VSP_009806; Epididymis-specific expression (at protein level). Associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. Highly glycosylated. Mutant male are infertile. Targeted disruption leads to sperm stasis and duct obstruction, resulting from dysregulation of fluid reabsorption. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. transmembrane signaling receptor activity G-protein coupled receptor activity cytosol plasma membrane integral component of plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway membrane integral component of membrane apical plasma membrane uc009uti.1 uc009uti.2 uc009uti.3 uc009uti.4 
ENSMUST00000112420.8 Slc38a11 ENSMUST00000112420.8 solute carrier family 38, member 11 (from RefSeq NM_177074.2) A2ASI0 A2ASI1 ENSMUST00000112420.1 ENSMUST00000112420.2 ENSMUST00000112420.3 ENSMUST00000112420.4 ENSMUST00000112420.5 ENSMUST00000112420.6 ENSMUST00000112420.7 NM_177074 Q3USY0 S38AB_MOUSE uc008jwj.1 uc008jwj.2 Putative sodium-dependent amino acid/proton antiporter. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3USY0-1; Sequence=Displayed; Name=2; IsoId=Q3USY0-2; Sequence=VSP_032530; Name=3; IsoId=Q3USY0-3; Sequence=VSP_032531; Belongs to the amino acid/polyamine transporter 2 family. Sequence=BAE24200.1; Type=Frameshift; Evidence=; Sequence=CAM23396.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM23397.1; Type=Erroneous gene model prediction; Evidence=; amino acid transmembrane transport ion transport sodium ion transport amino acid transport amino acid transmembrane transporter activity membrane integral component of membrane uc008jwj.1 uc008jwj.2 
ENSMUST00000112427.8 Zfp384 ENSMUST00000112427.8 zinc finger protein 384, transcript variant 6 (from RefSeq NM_001372424.1) E9Q1A5 E9Q1A5_MOUSE ENSMUST00000112427.1 ENSMUST00000112427.2 ENSMUST00000112427.3 ENSMUST00000112427.4 ENSMUST00000112427.5 ENSMUST00000112427.6 ENSMUST00000112427.7 NM_001372424 Zfp384 uc291ixq.1 uc291ixq.2 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding nucleus focal adhesion nucleocytoplasmic transport SH3 domain binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter positive regulation of protein secretion uc291ixq.1 uc291ixq.2 
ENSMUST00000112456.9 Sh3kbp1 ENSMUST00000112456.9 SH3-domain kinase binding protein 1, transcript variant 1 (from RefSeq NM_001135727.2) B1AZ86 B1AZ87 ENSMUST00000112456.1 ENSMUST00000112456.2 ENSMUST00000112456.3 ENSMUST00000112456.4 ENSMUST00000112456.5 ENSMUST00000112456.6 ENSMUST00000112456.7 ENSMUST00000112456.8 NM_001135727 Q8CAL8 Q8CEF6 Q8R545 Q8R546 Q8R547 Q8R548 Q8R549 Q8R550 Q8R551 Q9CTQ9 Q9DC14 Q9JKC3 Ruk SH3K1_MOUSE Seta uc009ust.1 uc009ust.2 uc009ust.3 uc009ust.4 uc009ust.5 Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3- kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration (By similarity). Has an essential role in the stimulation of B cell activation (By similarity). Can self-associate and form homotetramers. Interacts with CD2, F-actin capping protein, PIK3R3, GRB2, EGFR, MET, BLNK, MAP3K4, PDCD6IP, SPRY2, ARHGAP17, ARHGAP27, CRK, BCAR1, SOS1, ASAP1, ARAP3, HIP1R, SYNJ2, INPP5D and STAP1 (By similarity). Interacts with CBL (PubMed:21830225). Interacts with CBLB, but does not interact with CBLC. Two molecules of SH3KBP1 seem to bind through their respective SH3 1 domain to one molecule of CBLB. The interaction with CBL or CBLB and EGFR is increased upon EGF stimulation. The interaction with CBL is attenuated by PDCD6IP. Interacts through its proline-rich region with the SH3 domain of endophilins SH3GL1, SH3GL2 and SH3GL3. The SH3KBP1- endophilin complex seems to associate with a complex containing the phosphorylated receptor (EGFR or MET) and phosphorylated CBL. Probably associates with ASAP1 and phosphorylated EGFR. Probably part of a complex consisting of at least SH3KBP1, ASAP1 and ARAP3. Interacts with focal adhesion kinases PTK2/FAK1 and PTK2B/PYK2, probably as a dimer. Interacts with DAB2 and probably associates with chathrin through its interaction with DAB2. Part of a complex consisting of SH3KBP1, DAB2, and clathrin heavy chain. DAB2 and clathrin dissociate from SH3KBP1 following growth factor treatment, enabling interaction with CBL. Interacts with DDN and probably associates with MAGI2 through its interaction with DDN. Interacts with the SH3 domains of SRC tyrosine- protein kinases SRC, LCK, LYN, FGR, FYN and HCK. Interacts with TRADD, BIRC2, TRAF1, TRAF2 and TNFR1, and the association with a TNFR1- associated complex upon stimulation with TNF-alpha seems to be mediated by SRC. Probably part of a complex consisting of at least SH3KBP1, ASAP1 and ARAP3 (By similarity). Interacts (via SH3 domains) with SHKBP1 (via PXXXPR motifs) (PubMed:11152963, PubMed:21830225). Interacts with ATX2 (PubMed:18602463). Interaction with CBL is abolished in the presence of SHKBP1 (PubMed:21830225). Interacts (via SH3 domains) with ZFP36 (via extreme C-terminal region). Interacts with MAP3K4; this interaction enhances the association with ZFP36 (By similarity). Q8R550; Q62108: Dlg4; NbExp=3; IntAct=EBI-642709, EBI-300895; Cytoplasm Cytoplasm, cytoskeleton Cytoplasmic vesicle membrane ; Peripheral membrane protein Synapse, synaptosome Cell junction, focal adhesion Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes (By similarity). Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (PubMed:21830225). Colocalizes with ZFP36 in the cytoplasm (By similarity). Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=Ruk-xl; IsoId=Q8R550-1; Sequence=Displayed; Name=2; Synonyms=Ruk-l; IsoId=Q8R550-2; Sequence=VSP_007510; Name=3; Synonyms=Ruk-deltaA; IsoId=Q8R550-3; Sequence=VSP_007505, VSP_007510; Name=4; Synonyms=Ruk-m1; IsoId=Q8R550-4; Sequence=VSP_007507; Name=5; Synonyms=Ruk-m3; IsoId=Q8R550-5; Sequence=VSP_007506; Name=6; Synonyms=Ruk-t; IsoId=Q8R550-6; Sequence=VSP_007508; Name=7; Synonyms=Ruk-h; IsoId=Q8R550-7; Sequence=VSP_007509; Name=8; Synonyms=Ruk-deltaCP; IsoId=Q8R550-8; Sequence=VSP_007510, VSP_007511; Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus. protein binding cytoplasm cytoskeleton cell-cell junction focal adhesion endocytosis apoptotic process cytoskeleton organization actin filament organization regulation of cell shape membrane cell migration SH3 domain binding cell junction endocytic vesicle cytoplasmic vesicle membrane cytoplasmic vesicle ubiquitin protein ligase binding neuron projection synapse uc009ust.1 uc009ust.2 uc009ust.3 uc009ust.4 uc009ust.5 
ENSMUST00000112460.3 Pank1 ENSMUST00000112460.3 pantothenate kinase 1, transcript variant 2 (from RefSeq NM_023792.2) ENSMUST00000112460.1 ENSMUST00000112460.2 NM_023792 PANK1_MOUSE Pank Q8K4K6 Q9D3K1 Q9QXM8 uc008hgv.1 uc008hgv.2 uc008hgv.3 uc008hgv.4 uc008hgv.5 uc008hgv.6 Catalyzes the phosphorylation of pantothenate to generate 4'- phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:20559429, PubMed:22815849). Required for the hepatic CoA increase during the switch from glucose to fatty acid oxidation that occurs in the fasting state (PubMed:20559429). [Isoform 1]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. [Isoform 2]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Reaction=(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+); Xref=Rhea:RHEA:16373, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=2.7.1.33; Evidence= [Isoform 1]: Strongly inhibited by non-esterified CoA (CoASH), acetyl-CoA and malonyl-CoA (PubMed:12095677). Also inhibited by palmitoyl CoA (PubMed:12095677). Inhibited by calcium hopantenate (PubMed:17379144). [Isoform 2]: Strongly inhibited by acetyl-CoA and modestly by malonyl-CoA (PubMed:16040613, PubMed:10625688, PubMed:12095677). Refractory to inhibition by both CoA and palmitoyl- CoA (PubMed:16040613). Inhibited by calcium hopantenate (PubMed:17379144). [Isoform 2]: Kinetic parameters: KM=5.7 uM for pantothenate ; KM=87.0 uM for ATP ; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 1/5. [Isoform 2]: Homodimer. [Isoform 1]: Nucleus Nucleus, nucleolus [Isoform 2]: Cytoplasm Cytoplasmic vesicle, clathrin-coated vesicle Recycling endosome Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PanK1-alpha; IsoId=Q8K4K6-1; Sequence=Displayed; Name=2; Synonyms=PanK1-beta; IsoId=Q8K4K6-2; Sequence=VSP_004522, VSP_004523; [Isoform 1]: Highly expressed in the liver, heart and kidney. [Isoform 2]: Highly expressed in the liver (PubMed:10625688, PubMed:20559429, PubMed:16040613). Expressed at lower levels in the kidney (PubMed:10625688). [Isoform 1]: The N-terminal extension, may be the regulatory domain. Pank1 single knockout mice exhibit reduced hepatic CoA levels, a reduced rate of CoA-dependent fatty acid oxidation in the fasting state, impaired gluconeogenesis, and mild hypoglycemia in the fasting state (PubMed:20559429). Show a reduction in pantothenate kinase (PANK) activity of about 50% and 40% in the liver and brain respectively (PubMed:22815849). Pank1 and Pank2 double knockout mice develop progressively severe hypoglycemia and hyperketonemia by postnatal day 10 leading to their death by day 17 (PubMed:22815849). A reduction in PANK activity of about 90-95% seen in the liver and brain and hepatocytes show reduced levels of NADH (PubMed:22815849). Belongs to the type II pantothenate kinase family. nucleotide binding pantothenate kinase activity ATP binding nucleus cytosol coenzyme A biosynthetic process kinase activity phosphorylation transferase activity clathrin coat protein homodimerization activity recycling endosome cell periphery acetyl-CoA binding uc008hgv.1 uc008hgv.2 uc008hgv.3 uc008hgv.4 uc008hgv.5 uc008hgv.6 
ENSMUST00000112464.8 Bclaf3 ENSMUST00000112464.8 Bclaf1 and Thrap3 family member 3, transcript variant 6 (from RefSeq NR_152562.1) A2AG56 A2AG57 A2AG58 BCLA3_MOUSE Bclaf3 ENSMUST00000112464.1 ENSMUST00000112464.2 ENSMUST00000112464.3 ENSMUST00000112464.4 ENSMUST00000112464.5 ENSMUST00000112464.6 ENSMUST00000112464.7 NR_152562 Q3UM32 Q8BRL2 uc009usr.1 uc009usr.2 Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AG58-1; Sequence=Displayed; Name=2; IsoId=A2AG58-2; Sequence=VSP_025460; Belongs to the BCLAF1/THRAP3 family. Sequence=CAM23340.1; Type=Erroneous gene model prediction; Evidence=; molecular_function cellular_component mitochondrion biological_process uc009usr.1 uc009usr.2 
ENSMUST00000112467.2 Ifit1bl1 ENSMUST00000112467.2 interferon induced protein with tetratricpeptide repeats 1B like 1, transcript variant 1 (from RefSeq NM_001110517.1) D3Z6F0 D3Z6F0_MOUSE ENSMUST00000112467.1 Gm14446 Ifit1bl1 NM_001110517 uc012bku.1 uc012bku.2 uc012bku.3 Belongs to the IFIT family. RNA binding cytoplasm cytosol response to virus regulation of defense response to virus defense response to virus cellular response to type I interferon cellular response to exogenous dsRNA uc012bku.1 uc012bku.2 uc012bku.3 
ENSMUST00000112475.9 Lrrc23 ENSMUST00000112475.9 leucine rich repeat containing 23 (from RefSeq NM_001302555.1) ENSMUST00000112475.1 ENSMUST00000112475.2 ENSMUST00000112475.3 ENSMUST00000112475.4 ENSMUST00000112475.5 ENSMUST00000112475.6 ENSMUST00000112475.7 ENSMUST00000112475.8 LRC23_MOUSE Lrpb7 NM_001302555 O35125 uc009drv.1 uc009drv.2 uc009drv.3 molecular_function cytoplasm cytosol biological_process uc009drv.1 uc009drv.2 uc009drv.3 
ENSMUST00000112478.8 P2rx2 ENSMUST00000112478.8 purinergic receptor P2X, ligand-gated ion channel, 2, transcript variant 2 (from RefSeq NM_001164833.1) ENSMUST00000112478.1 ENSMUST00000112478.2 ENSMUST00000112478.3 ENSMUST00000112478.4 ENSMUST00000112478.5 ENSMUST00000112478.6 ENSMUST00000112478.7 NM_001164833 P2RX2_MOUSE P2x2 Q3KP15 Q3TYV0 Q812E6 Q812E7 Q8K3P1 uc008yqu.1 uc008yqu.2 uc008yqu.3 uc008yqu.4 Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. Homotrimer and heterotrimer; functional P2XRs are organized as homomeric and heteromeric trimers. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8K3P1-1; Sequence=Displayed; Name=2; IsoId=Q8K3P1-2; Sequence=VSP_053890; Name=3; IsoId=Q8K3P1-3; Sequence=VSP_053889; Name=4; IsoId=Q8K3P1-4; Sequence=VSP_053887; Name=5; IsoId=Q8K3P1-5; Sequence=VSP_053888; In skeletal muscle, strongly expressed in postnatal day 3 (P3), P7 and P15 muscles. Expression is not maintained in P21 in adult skeletal muscle (at protein level). Mice show small differences in body weight, but are visibly and histopathologically normal for up to 1 year of age. Simultaneous knockout of P2rx2 and P2rx3 results in reduced pain- related behaviors in response to intraplantar injection of formalin and reduced urinary bladder reflexes and decreased pelvic afferent nerve activity in response to bladder distension. Neurons have minimal to no response to ATP (PubMed:15961431). P2rx2 null mice show impaired peristalsis in ileal segments of small intestine (PubMed:12937291). P2rx2 null mice show disorganized neuromuscular junctions (NMJ) with misapposition of nerve terminals and post-synaptic AChR expression localization, reduction of the density of post-synaptic and increased end-plate fragmentation. These changes in NMJ structure are associated with muscle fiber atrophy and an increase in the proportion of fast type muscle fibers (PubMed:17706883). P2rx2 null mice display age- related hearing loss: in the absence of exposure to noise, auditory thresholds are normal until at least age 19-23 week. Then, mice develop severe progressive hearing loss, and their early exposure to continuous moderate noise leads to high-frequency hearing loss as young adults (PubMed:23345450). Simultaneous knockout of P2rx2 and P2rx3 results in defects in taste responses in the taste nerves and reduced behavioral responses to sweeteners, glutamate and bitter substances (PubMed:16322458). Belongs to the P2X receptor family. purinergic nucleotide receptor activity response to hypoxia response to ischemia detection of hypoxic conditions in blood by carotid body chemoreceptor signaling transcription coactivator activity extracellular ATP-gated cation channel activity ion channel activity copper ion binding ATP binding integral component of nuclear inner membrane plasma membrane integral component of plasma membrane ion transport chemical synaptic transmission neuromuscular synaptic transmission neuromuscular junction development sensory perception of sound drug binding zinc ion binding response to carbohydrate cell surface response to organic substance postsynaptic density urinary bladder smooth muscle contraction ligand-gated ion channel activity membrane integral component of membrane nickel cation binding apical plasma membrane neuronal action potential peristalsis response to ATP phosphatidylinositol binding purinergic nucleotide receptor signaling pathway presynaptic membrane identical protein binding neuronal cell body terminal bouton dendritic spine receptor complex mercury ion binding cadmium ion binding behavioral response to pain skeletal muscle fiber development cobalt ion binding sensory perception of taste protein homooligomerization protein heterooligomerization excitatory postsynaptic potential cation transmembrane transport glutamatergic synapse integral component of presynaptic active zone membrane regulation of presynaptic cytosolic calcium ion concentration positive regulation of nucleic acid-templated transcription regulation of synaptic vesicle exocytosis uc008yqu.1 uc008yqu.2 uc008yqu.3 uc008yqu.4 
ENSMUST00000112484.10 Ptpn6 ENSMUST00000112484.10 protein tyrosine phosphatase, non-receptor type 6, transcript variant 1 (from RefSeq NM_013545.3) ENSMUST00000112484.1 ENSMUST00000112484.2 ENSMUST00000112484.3 ENSMUST00000112484.4 ENSMUST00000112484.5 ENSMUST00000112484.6 ENSMUST00000112484.7 ENSMUST00000112484.8 ENSMUST00000112484.9 Hcp Hcph NM_013545 O35128 P29351 PTN6_MOUSE Ptp1C Q63872 Q63873 Q63874 Q921G3 Q9QVA6 Q9QVA7 Q9QVA8 Q9R0V6 uc009drk.1 uc009drk.2 uc009drk.3 Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. Enhances the inhibition of mast cell activation mediated by the Lilrb4a receptor (PubMed:10026201). The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Monomer. Interacts with MTUS1 (By similarity). Interacts with MILR1 (tyrosine-phosphorylated) (PubMed:20526344). Interacts with KIT (PubMed:9528781). Interacts with SIRPA/PTPNS1 (PubMed:9712903). Interacts with FCRL2 and FCRL4 (By similarity). Interacts with CD84 (By similarity). Interacts with CD300LF (PubMed:14662855). Interacts with CDK2 (By similarity). Interacts with KIR2DL1; the interaction is enhanced by ARRB2 (By similarity). Interacts (via SH2 1 domain) with ROS1; the interaction is direct and promotes ROS1 dephosphorylation (By similarity). Interacts with EGFR; inhibits EGFR-dependent activation of MAPK/ERK (By similarity). Interacts with LYN (By similarity). Interacts with the tyrosine phosphorylated form of PDPK1 (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction depends on the monomer/dimer equilibrium and is phosphorylation- dependent (PubMed:19948503, PubMed:9867848). Interacts with MPIG6B (via ITIM motif) (PubMed:23112346). Interacts with KLRI1 and KLRI2 (By similarity). Interacts with moesin/MSN. Interacts with Lilrb4a (when tyrosine phosphorylated); the interaction enhances Lilrb4a-mediated inhibition of mast cell activation (PubMed:10026201, PubMed:9973385). Interacts with CLEC12B (via ITIM motif). P29351; Q91YS8: Camk1; NbExp=3; IntAct=EBI-2620699, EBI-911352; P29351; P35329: Cd22; NbExp=5; IntAct=EBI-2620699, EBI-300059; P29351; Q9Z1S8: Gab2; NbExp=2; IntAct=EBI-2620699, EBI-641738; P29351; P42225: Stat1; NbExp=2; IntAct=EBI-2620699, EBI-647118; P29351; B7UM99: tir; Xeno; NbExp=2; IntAct=EBI-2620699, EBI-2504426; Cytoplasm. Nucleus Note=In neurons, translocates into the nucleus after treatment with angiotensin II. Shuttles between the cytoplasm and nucleus via its association with PDPK1 (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P29351-1; Sequence=Displayed; Name=2; IsoId=P29351-2; Sequence=VSP_005131; Name=3; IsoId=P29351-3; Sequence=VSP_005132, VSP_005133; Expressed predominantly in hematopoietic cells. The N-terminal SH2 domain functions as an auto-inhibitory domain, blocking the catalytic domain in the ligand-free close conformation. Phosphorylated on tyrosine residues. Phosphorylation at Tyr-564 enhances phosphatase activity (By similarity). Binding of KITLG/SCF to KIT increases tyrosine phosphorylation. Note=Defects in Ptpn6 are the cause of the motheaten (me) or viable motheaten (mev) phenotypes. Mice homozygous for the recessive allelic mutations develop severe defects in hematopoiesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. phosphotyrosine binding hematopoietic progenitor cell differentiation negative regulation of humoral immune response mediated by circulating immunoglobulin phosphoprotein phosphatase activity protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding nucleus nucleolus cytoplasm cytosol cell-cell junction protein dephosphorylation cell proliferation positive regulation of cell proliferation positive regulation of phosphatidylinositol 3-kinase signaling dephosphorylation hydrolase activity phosphatase activity SH3 domain binding peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway protein kinase binding cell differentiation platelet formation negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production macromolecular complex abortive mitotic cell cycle positive regulation of cell adhesion mediated by integrin peptidyl-tyrosine dephosphorylation intracellular signal transduction megakaryocyte development alpha-beta T cell receptor complex negative regulation of T cell proliferation SH2 domain binding natural killer cell mediated cytotoxicity negative regulation of MAP kinase activity negative regulation of MAPK cascade regulation of B cell differentiation natural killer cell lectin-like receptor binding negative regulation of peptidyl-tyrosine phosphorylation cell adhesion molecule binding B cell receptor signaling pathway negative regulation of T cell receptor signaling pathway regulation of release of sequestered calcium ion into cytosol regulation of ERK1 and ERK2 cascade platelet aggregation regulation of G1/S transition of mitotic cell cycle uc009drk.1 uc009drk.2 uc009drk.3 
ENSMUST00000112487.3 Fez2 ENSMUST00000112487.3 fasciculation and elongation protein zeta 2, transcript variant 1 (from RefSeq NM_001285940.1) D3Z6D5 D3Z6D5_MOUSE ENSMUST00000112487.1 ENSMUST00000112487.2 Fez2 NM_001285940 uc008dow.1 uc008dow.2 uc008dow.3 uc008dow.4 Belongs to the zygin family. negative regulation of autophagosome assembly uc008dow.1 uc008dow.2 uc008dow.3 uc008dow.4 
ENSMUST00000112488.9 Cd55b ENSMUST00000112488.9 CD55 molecule, decay accelerating factor for complement B, transcript variant 4 (from RefSeq NR_175893.1) Cd55b Daf2 E9QAP4 E9QAP4_MOUSE ENSMUST00000112488.1 ENSMUST00000112488.2 ENSMUST00000112488.3 ENSMUST00000112488.4 ENSMUST00000112488.5 ENSMUST00000112488.6 ENSMUST00000112488.7 ENSMUST00000112488.8 NR_175893 uc007clx.1 uc007clx.2 uc007clx.3 uc007clx.4 Belongs to the receptors of complement activation (RCA) family. Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc007clx.1 uc007clx.2 uc007clx.3 uc007clx.4 
ENSMUST00000112498.3 Crim1 ENSMUST00000112498.3 cysteine rich transmembrane BMP regulator 1, transcript variant 1 (from RefSeq NM_015800.3) CRIM1_MOUSE ENSMUST00000112498.1 ENSMUST00000112498.2 NM_015800 Q497W4 Q9JLL0 uc008dou.1 uc008dou.2 uc008dou.3 May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (By similarity). Interacts with BMP4 and BMP7. Membrane ; Single-pass type I membrane protein Expressed during embryonic development in brain, kidney, spinal chord, testis, lens, vibrissae, pinna, tooth primordia and in specific regions of the CNS. Expressed in adult lens. Displays male-specific expression in the fetal gonads with the strongest expression in the Sertoli cells of developing testis. Detected in embryo at 11.5 dpc to 17.7 dpc with a maximum between 12.5 and 13.5 dpc. enzyme inhibitor activity serine-type endopeptidase inhibitor activity insulin-like growth factor binding extracellular region negative regulation of endopeptidase activity membrane integral component of membrane PDZ domain binding negative regulation of catalytic activity uc008dou.1 uc008dou.2 uc008dou.3 
ENSMUST00000112501.9 Tank ENSMUST00000112501.9 TRAF family member-associated Nf-kappa B activator, transcript variant 6 (from RefSeq NR_149323.1) ENSMUST00000112501.1 ENSMUST00000112501.2 ENSMUST00000112501.3 ENSMUST00000112501.4 ENSMUST00000112501.5 ENSMUST00000112501.6 ENSMUST00000112501.7 ENSMUST00000112501.8 Itraf NR_149323 P70347 Q61178 TANK_MOUSE uc008juz.1 uc008juz.2 uc008juz.3 uc008juz.4 Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1- mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1- beta (IL1B) stimulation or upon DNA damage. Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus. Homodimer (By similarity). Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta-mediated NF-kappaB activation by promoting IKBKG or TRAF6 deubiquitination (By similarity). Interacts with IKBKG; this interaction increases in response to DNA damage (By similarity). Interacts with TRAF6; this interaction increases in response to DNA damage and recruits USP10 to the ubiquitinated TRAF6 (By similarity). Interacts with USP10; this interaction increases in response to DNA damage (By similarity). Interacts with TBK1 and IKBKE (By similarity). Interacts also with TRAF1, TRAF2, and TRAF3 by binding to their TRAF-C domains; the interaction with TRAF2 is disrupted by the phosphorylation of TANK by IKBKE (By similarity). Interacts more strongly with TRAF1 and TRAF2 than TRAF3 (By similarity). Part of a ternary complex consisting of TANK, IKBKB and IKBKG (By similarity). Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1 (PubMed:12133833). P70347; Q9WUN2: Tbk1; NbExp=7; IntAct=EBI-646116, EBI-764193; P70347-1; P39428: Traf1; NbExp=12; IntAct=EBI-646125, EBI-520123; P70347-1; P39429: Traf2; NbExp=7; IntAct=EBI-646125, EBI-520016; Cytoplasm. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Beta; IsoId=P70347-1; Sequence=Displayed; Name=2; Synonyms=Alpha; IsoId=P70347-2; Sequence=VSP_004444; Name=3; Synonyms=Gamma; IsoId=P70347-3; Sequence=VSP_004445, VSP_004446; Name=4; IsoId=P70347-4; Sequence=VSP_004447, VSP_004448; Heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. thiol-dependent ubiquitin-specific protease activity protein binding cytoplasm cytosol proteolysis cellular response to DNA damage stimulus I-kappaB kinase/NF-kappaB signaling ubiquitin protein ligase binding macromolecular complex deubiquitinase activator activity negative regulation of I-kappaB kinase/NF-kappaB signaling metal ion binding cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to ionizing radiation positive regulation of protein deubiquitination positive regulation of ubiquitin-specific protease activity uc008juz.1 uc008juz.2 uc008juz.3 uc008juz.4 
ENSMUST00000112507.4 Fam98a ENSMUST00000112507.4 family with sequence similarity 98, member A, transcript variant 1 (from RefSeq NM_133747.2) ENSMUST00000112507.1 ENSMUST00000112507.2 ENSMUST00000112507.3 FA98A_MOUSE Fam98a NM_133747 Q3TJZ6 Q99KJ2 uc008doq.1 uc008doq.2 Positively stimulates PRMT1-induced protein arginine methylation (By similarity). Involved in skeletal homeostasis (PubMed:27777970). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970). Interacts (via N- and C-terminus) with DDX1 (By similarity). Interacts (via N- and C-terminus) with C14orf166 (By similarity). Interacts with FAM98B (By similarity). Interacts with PLEKHM1 (via N- and C-terminus) (PubMed:27777970). Belongs to the FAM98 family. Sequence=AAH04626.1; Type=Erroneous initiation; Evidence=; protein binding protein methylation protein methyltransferase activity positive regulation of cell proliferation positive regulation of gene expression lysosome localization tRNA-splicing ligase complex positive regulation of ruffle assembly uc008doq.1 uc008doq.2 
ENSMUST00000112512.8 Golga3 ENSMUST00000112512.8 golgin A3, transcript variant 2 (from RefSeq NM_008146.4) A0A0R4J1H6 A0A0R4J1H6_MOUSE ENSMUST00000112512.1 ENSMUST00000112512.2 ENSMUST00000112512.3 ENSMUST00000112512.4 ENSMUST00000112512.5 ENSMUST00000112512.6 ENSMUST00000112512.7 Golga3 NM_008146 uc008yqd.1 uc008yqd.2 uc008yqd.3 spermatogenesis extrinsic component of Golgi membrane uc008yqd.1 uc008yqd.2 uc008yqd.3 
ENSMUST00000112516.8 Ltbp1 ENSMUST00000112516.8 latent transforming growth factor beta binding protein 1, transcript variant 2 (from RefSeq NM_206958.3) B1B1D9 B1B1E1 ENSMUST00000112516.1 ENSMUST00000112516.2 ENSMUST00000112516.3 ENSMUST00000112516.4 ENSMUST00000112516.5 ENSMUST00000112516.6 ENSMUST00000112516.7 LTBP1_MOUSE Ltbp1 NM_206958 O88349 Q505C9 Q8BNW7 Q8C7F5 Q8CG18 Q8CG19 Q8CIR0 uc008doo.1 uc008doo.2 uc008doo.3 uc008doo.4 Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta. Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1. LTBP1 does not bind directly to TGF-beta-1, the active chain of TGFB1. Interacts (via C- terminal domain) with FBN1 (via N-terminal domain). Interacts with FBN2. Interacts with ADAMTSL2. Interacts with EFEMP2 (By similarity). Secreted Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=3; Name=Long; Synonyms=LTBP-1L; IsoId=Q8CG19-1; Sequence=Displayed; Name=Short; Synonyms=LTBP-1S; IsoId=Q8CG19-2, Q8CG18-1; Sequence=VSP_036968, VSP_036969; Name=3; IsoId=Q8CG19-3; Sequence=VSP_036968, VSP_036969, VSP_036970; The 8-Cys3 region in the third TB domain mediates the interchain disulfide bond interaction with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1. Contains hydroxylated asparagine residues. Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix. O-glycosylated on serine residues by POGLUT2 and POGLUT3. Belongs to the LTBP family. microfibril ventricular septum development extracellular matrix structural constituent calcium ion binding extracellular region extracellular space cytoplasm mitochondrion transforming growth factor beta receptor signaling pathway growth factor binding dendrite extracellular matrix positive regulation of collagen biosynthetic process macromolecular complex sequestering of TGFbeta in extracellular matrix aorta development large latent transforming growth factor-beta complex neuronal cell body perinuclear region of cytoplasm transforming growth factor beta binding microfibril binding coronary vasculature development regulation of transforming growth factor beta activation uc008doo.1 uc008doo.2 uc008doo.3 uc008doo.4 
ENSMUST00000112519.9 Chfr ENSMUST00000112519.9 checkpoint with forkhead and ring finger domains, transcript variant 4 (from RefSeq NM_001289579.1) CHFR_MOUSE ENSMUST00000112519.1 ENSMUST00000112519.2 ENSMUST00000112519.3 ENSMUST00000112519.4 ENSMUST00000112519.5 ENSMUST00000112519.6 ENSMUST00000112519.7 ENSMUST00000112519.8 NM_001289579 Q3TFD8 Q3U233 Q3U4U9 Q3UGJ9 Q810L3 Q8BJZ9 Q8BWH4 uc008ypy.1 uc008ypy.2 uc008ypy.3 uc008ypy.4 uc008ypy.5 E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys- 48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'- linked polyubiquitin chains and functions with the specific ubiquitin- conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with HDAC1 and HDAC2. Interacts with PML (with sumoylated form of PML). Nucleus, PML body Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q810L3-1; Sequence=Displayed; Name=2; IsoId=Q810L3-2; Sequence=VSP_009351; Name=3; IsoId=Q810L3-3; Sequence=VSP_038129; Name=4; IsoId=Q810L3-4; Sequence=VSP_038128; The PBZ-type zinc finger (also named CYR) mediates non-covalent poly(ADP-ribose)-binding. Poly(ADP-ribose)-binding is dependent on the presence of zinc and is required for its function in antephase checkpoint. The FHA domain plays a key role in the anti-proliferative properties of the protein and is involved in initiating a cell cycle arrest at G2/M. The FHA domain may be required to interact with phosphorylated proteins. Poly-ADP-ribosylated. In addition to binding non covalently poly(ADP-ribose) via its PBZ-type zinc finger, the protein is also covalently poly-ADP-ribosylated by PARP1. Autoubiquitinated; may regulate its cellular level. Phosphorylated by PKB. Phosphorylation may affect its E3 ligase activity. Mice are viable and have no obvious developmental defects. They are however cancer-prone and develop spontaneous tumors. They also display increased skin tumor incidence after treatment with dimethylbenz(a)anthracene. Belongs to the CHFR family. nucleotide binding protein polyubiquitination mitotic cell cycle ubiquitin-protein transferase activity protein binding nucleus ubiquitin-dependent protein catabolic process cell cycle mitotic cell cycle checkpoint protein ubiquitination PML body transferase activity modification-dependent protein catabolic process positive regulation of protein ubiquitination protein destabilization positive regulation of proteasomal ubiquitin-dependent protein catabolic process metal ion binding cell division ubiquitin protein ligase activity uc008ypy.1 uc008ypy.2 uc008ypy.3 uc008ypy.4 uc008ypy.5 
ENSMUST00000112523.8 Clstn3 ENSMUST00000112523.8 calsyntenin 3, transcript variant 2 (from RefSeq NM_001346656.1) Clstn3 D3Z601 D3Z601_MOUSE ENSMUST00000112523.1 ENSMUST00000112523.2 ENSMUST00000112523.3 ENSMUST00000112523.4 ENSMUST00000112523.5 ENSMUST00000112523.6 ENSMUST00000112523.7 NM_001346656 uc291ist.1 uc291ist.2 Endoplasmic reticulum membrane ; Single-pass type I membrane protein Golgi apparatus membrane ; Single-pass type I membrane protein Postsynaptic cell membrane ; Single-pass type I membrane protein Belongs to the calsyntenin family. calcium ion binding homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc291ist.1 uc291ist.2 
ENSMUST00000112525.5 Pla2r1 ENSMUST00000112525.5 phospholipase A2 receptor 1 (from RefSeq NM_008867.2) A2AS64 B9EJ68 ENSMUST00000112525.1 ENSMUST00000112525.2 ENSMUST00000112525.3 ENSMUST00000112525.4 NM_008867 PLA2R_MOUSE Pla2g1br Q62028 Q80ZL5 uc008jug.1 uc008jug.2 uc008jug.3 Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipases sPLA2-IB/PLA2G1B, sPLA2-X/PLA2G10 and, with lower affinity, sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in pro-inflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10. In podocytes, binding of sPLA2-IB/PLA2G1B can regulate podocyte survival and glomerular homeostasis. Interacts with sPLA2-IB/PLA2G1B; this interaction mediates intracellular signaling as well as clearance of extracellular sPLA2- IB/PLA2G1B via endocytotic pathway (PubMed:10066760). Interacts with sPLA2-X/PLA2G10; this interaction mediates sPLA2-X/PLA2G10 clearance and inactivation (PubMed:10922494, PubMed:11741598). Cell membrane ; Single-pass type I membrane protein [Soluble secretory phospholipase A2 receptor]: Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q62028-1; Sequence=Displayed; Name=2; IsoId=Q62028-2; Sequence=VSP_029495, VSP_029496; Widely expressed. Present in type II alveolar epithelial cells and a subset of splenic lymphocytes. Present at the surface of polymorphonuclear neutrophils (at protein level). Following exposure to endotoxin (at protein level). C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B. The endocytosis signal probably mediates endocytosis via clathrin-coated pits. The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments reported by PubMed:11830583, or by alternative splicing. Mice are viable, fertile and without evident histopathological abnormalities. After challenge with bacterial lipopolysaccharide (LPS), they exhibit longer survival than wild-type mice. They are also resistant to lethal effects of exogenous sPLA2- IB/PLA2G1B after sensitization with sublethal dose of LPS, suggesting a potential role in the progression of endotoxic shock. Sequence=CAM22305.1; Type=Erroneous initiation; Evidence=; Sequence=CAM23630.1; Type=Erroneous initiation; Evidence=; Name=Functional Glycomics Gateway - Glycan Binding; Note=Phospholipase A2 receptor; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_356"; cytokine production transmembrane signaling receptor activity extracellular region plasma membrane endocytosis receptor-mediated endocytosis cell surface membrane integral component of membrane carbohydrate binding signaling receptor activity receptor complex phospholipase binding positive regulation of DNA damage response, signal transduction by p53 class mediator reactive oxygen species metabolic process positive regulation of arachidonic acid secretion replicative senescence oxidative stress-induced premature senescence negative regulation of phospholipase A2 activity negative regulation of arachidonic acid secretion uc008jug.1 uc008jug.2 uc008jug.3 
ENSMUST00000112528.8 Zfp605 ENSMUST00000112528.8 zinc finger protein 605 (from RefSeq NM_001163996.1) E9QAH2 E9QAH2_MOUSE ENSMUST00000112528.1 ENSMUST00000112528.2 ENSMUST00000112528.3 ENSMUST00000112528.4 ENSMUST00000112528.5 ENSMUST00000112528.6 ENSMUST00000112528.7 F6VFU8 NM_001163996 Zfp605 uc008yps.1 uc008yps.2 uc008yps.3 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc008yps.1 uc008yps.2 uc008yps.3 
ENSMUST00000112529.8 Sms ENSMUST00000112529.8 spermine synthase, transcript variant 1 (from RefSeq NM_009214.4) A2AC82 ENSMUST00000112529.1 ENSMUST00000112529.2 ENSMUST00000112529.3 ENSMUST00000112529.4 ENSMUST00000112529.5 ENSMUST00000112529.6 ENSMUST00000112529.7 NM_009214 P97355 Q3TL65 Q3TUP0 Q3UDT8 Q8C7P4 Q9CT09 Q9R282 SPSY_MOUSE uc033jve.1 uc033jve.2 uc033jve.3 Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM) (PubMed:9467015). Required for normal viability, growth and fertility (PubMed:15459188). Reaction=S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + spermine; Xref=Rhea:RHEA:19973, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:45725, ChEBI:CHEBI:57443, ChEBI:CHEBI:57834; EC=2.5.1.22; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19974; Evidence=; Amine and polyamine biosynthesis; spermine biosynthesis; spermine from spermidine: step 1/1. Homodimer. Dimerization is mediated through the N-terminal domain and seems to be required for activity as deletion of the N- terminal domain causes complete loss of activity. Composed of 3 domains: the N-terminal domain has structural similarity to S-adenosylmethionine decarboxylase, the central domain is made up of four beta strands and the C-terminal domain is similar in structure to spermidine synthase. The N- and C-terminal domains are both required for activity. Mouse ES cells lacking Sms display normal growth rates but are sensitive to antiproliferative and DNA damage-inducing drugs. Belongs to the spermidine/spermine synthase family. polyamine biosynthetic process spermine biosynthetic process spermine metabolic process transferase activity spermine synthase activity uc033jve.1 uc033jve.2 uc033jve.3 
ENSMUST00000112538.4 Zranb3 ENSMUST00000112538.4 zinc finger, RAN-binding domain containing 3, transcript variant 3 (from RefSeq NM_001357573.1) ENSMUST00000112538.1 ENSMUST00000112538.2 ENSMUST00000112538.3 NM_001357573 Q148X9 Q6NZP1 Q8BJJ3 Q8BWT6 ZRAB3_MOUSE uc007cle.1 uc007cle.2 uc007cle.3 uc007cle.4 DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D- loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double- strand breaks. Interacts (via PIP-box and RanBP2-type zinc finger) with PCNA (when PCNA is polyubiquitinated via 'Lys-63'-linked polyubiquitin). Nucleus Chromosome Note=Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA. The PIP-box mediates the interaction with PCNA, while the RanBP2-type zinc finger mediates binding to 'Lys-63'-linked polyubiquitin. In contrast to classical helicases that unwing DNA, annealing helicases rewind it. Belongs to the SNF2/RAD54 helicase family. nucleotide binding DNA strand renaturation nucleic acid binding catalytic activity helicase activity nuclease activity endonuclease activity endodeoxyribonuclease activity ATP binding nucleus chromosome DNA repair cellular response to DNA damage stimulus DNA-dependent ATPase activity metabolic process response to UV hydrolase activity replication fork processing DNA duplex unwinding DNA rewinding annealing helicase activity nuclear replication fork negative regulation of DNA recombination metal ion binding replication fork protection K63-linked polyubiquitin binding nucleic acid phosphodiester bond hydrolysis DNA helicase activity uc007cle.1 uc007cle.2 uc007cle.3 uc007cle.4 
ENSMUST00000112542.2 Gm15155 ENSMUST00000112542.2 Gm15155 (from geneSymbol) AK028243 B1B034 B1B034_MOUSE ENSMUST00000112542.1 Gm15155 uc009urx.1 uc009urx.2 uc009urx.3 molecular_function cellular_component biological_process uc009urx.1 uc009urx.2 uc009urx.3 
ENSMUST00000112543.9 Glyctk ENSMUST00000112543.9 glycerate kinase, transcript variant 2 (from RefSeq NM_001039586.1) A0A0R4J1H2 A0A0R4J1H2_MOUSE ENSMUST00000112543.1 ENSMUST00000112543.2 ENSMUST00000112543.3 ENSMUST00000112543.4 ENSMUST00000112543.5 ENSMUST00000112543.6 ENSMUST00000112543.7 ENSMUST00000112543.8 Glyctk NM_001039586 uc009riz.1 uc009riz.2 uc009riz.3 Reaction=(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+); Xref=Rhea:RHEA:23516, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659, ChEBI:CHEBI:30616, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216; EC=2.7.1.31; Evidence=; Belongs to the glycerate kinase type-2 family. cytoplasm Golgi apparatus cytosol protein phosphorylation glycerate kinase activity uc009riz.1 uc009riz.2 uc009riz.3 
ENSMUST00000112544.8 Gm15446 ENSMUST00000112544.8 Belongs to the krueppel C2H2-type zinc-finger protein family. (from UniProt D3Z5Y8) AK142681 D3Z5Y8 D3Z5Y8_MOUSE ENSMUST00000112544.1 ENSMUST00000112544.2 ENSMUST00000112544.3 ENSMUST00000112544.4 ENSMUST00000112544.5 ENSMUST00000112544.6 ENSMUST00000112544.7 Gm15446 uc290yci.1 uc290yci.2 Belongs to the krueppel C2H2-type zinc-finger protein family. transcription regulatory region sequence-specific DNA binding molecular_function nucleic acid binding cellular_component nucleus regulation of transcription, DNA-templated biological_process metal ion binding uc290yci.1 uc290yci.2 
ENSMUST00000112547.9 4930522L14Rik ENSMUST00000112547.9 RIKEN cDNA 4930522L14 gene, transcript variant 1 (from RefSeq NM_001378567.1) 4930522L14Rik E9QAG4 E9QAG4_MOUSE ENSMUST00000112547.1 ENSMUST00000112547.2 ENSMUST00000112547.3 ENSMUST00000112547.4 ENSMUST00000112547.5 ENSMUST00000112547.6 ENSMUST00000112547.7 ENSMUST00000112547.8 NM_001378567 uc290yce.1 uc290yce.2 uc290yce.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc290yce.1 uc290yce.2 uc290yce.3 
ENSMUST00000112550.8 Baz2b ENSMUST00000112550.8 bromodomain adjacent to zinc finger domain, 2B (from RefSeq NM_001001182.3) A2AUY4 B9EKB5 BAZ2B_MOUSE Baz2b ENSMUST00000112550.1 ENSMUST00000112550.2 ENSMUST00000112550.3 ENSMUST00000112550.4 ENSMUST00000112550.5 ENSMUST00000112550.6 ENSMUST00000112550.7 NM_001001182 Q8C0K4 Q8CFP4 uc289whr.1 uc289whr.2 Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (By similarity). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (By similarity). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (By similarity). Chromatin reader protein, involved in positively modulating the rate of age-related behavioral deterioration (PubMed:32103178). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (PubMed:32103178). Component of the BRF-1 ISWI chromatin remodeling complex, at least composed of SMARCA1 and BAZ2B, which regulates the spacing of histone octamers on the DNA template to facilitate access to DNA (By similarity). Within the BRF-1 ISWI chromatin remodeling complex interacts with SMARCA1; the interaction is direct (By similarity). Component of the BRF-5 ISWI chromatin remodeling complex, at least composed of SMARCA5/SNF2H and BAZ2B, which regulates the spacing of histone octamers on the DNA template to facilitate access to DNA (By similarity). Within the BRF-5 ISWI chromatin remodeling complex interacts with SMARCA5/SNF2H; the interaction is direct (By similarity). Interacts with acetylated lysine residues on histone H1.4, H2A, H2B, H3 and H4 (in vitro) (By similarity). Interacts with EHMT1 (PubMed:32103178). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=A2AUY4-1; Sequence=Displayed; Name=2 ; IsoId=A2AUY4-2; Sequence=VSP_060916, VSP_060917, VSP_060918; Belongs to the WAL family. Sequence=AAH42646.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function DNA binding cellular_component nucleus biological_process metal ion binding uc289whr.1 uc289whr.2 
ENSMUST00000112558.10 Atp2c1 ENSMUST00000112558.10 ATPase, Ca++-sequestering, transcript variant 3 (from RefSeq NM_001253834.1) AT2C1_MOUSE Atp2c1 E9QMB9 ENSMUST00000112558.1 ENSMUST00000112558.2 ENSMUST00000112558.3 ENSMUST00000112558.4 ENSMUST00000112558.5 ENSMUST00000112558.6 ENSMUST00000112558.7 ENSMUST00000112558.8 ENSMUST00000112558.9 NM_001253834 Pmr1 Q80XR2 Q80YZ2 uc009rig.1 uc009rig.2 uc009rig.3 uc009rig.4 uc009rig.5 ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (By similarity). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (By similarity). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (PubMed:19793975). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (By similarity). Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.10; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18106; Evidence=; Reaction=ATP + H2O + Mn(2+)(in) = ADP + H(+) + Mn(2+)(out) + phosphate; Xref=Rhea:RHEA:66820, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29035, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66821; Evidence=; Monomer. Homodimer. Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein Note=During neuron differentiation, shifts from juxtanuclear Golgi position to multiple Golgi structures distributed over the neural soma with a predominance in the apical dendritic trunk. Expressed in hippocampal neurons in the CA3 region of the Amon's horn (at protein level) (PubMed:19793975). Expressed in brain, heart, lung, stomach, liver, colon and mammary gland (PubMed:17597066). Mutant mice, born at the expected Mendelian rate, show growth retardation and exencephaly by 9.5 dpc and die by 10.5 dpc. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. Golgi membrane nucleotide binding calcium-transporting ATPase activity calcium ion binding ATP binding Golgi apparatus trans-Golgi network plasma membrane ion transport calcium ion transport manganese ion transport cellular calcium ion homeostasis epidermis development hydrogen-exporting ATPase activity, phosphorylative mechanism manganese-transporting ATPase activity membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cellular manganese ion homeostasis transport vesicle secretory granule manganese ion binding actin cytoskeleton reorganization Golgi calcium ion homeostasis Golgi calcium ion transport Golgi cisterna membrane positive regulation of I-kappaB kinase/NF-kappaB signaling intracellular membrane-bounded organelle metal ion binding calcium ion transmembrane transport manganese ion transmembrane transport hydrogen ion transmembrane transport uc009rig.1 uc009rig.2 uc009rig.3 uc009rig.4 uc009rig.5 
ENSMUST00000112562.8 Magea6 ENSMUST00000112562.8 Magea6 (from geneSymbol) BC109339 ENSMUST00000112562.1 ENSMUST00000112562.2 ENSMUST00000112562.3 ENSMUST00000112562.4 ENSMUST00000112562.5 ENSMUST00000112562.6 ENSMUST00000112562.7 Magea6 O89010 O89010_MOUSE uc033juz.1 uc033juz.2 uc033juz.3 molecular_function cellular_component biological_process uc033juz.1 uc033juz.2 uc033juz.3 
ENSMUST00000112565.2 Samt1d ENSMUST00000112565.2 spermatogenesis associated multipass transmembrane protein 1d (from RefSeq NM_001243017.1) A2BEE3 A2BEE3_MOUSE ENSMUST00000112565.1 Gm15140 NM_001243017 Samt1d uc009urg.1 uc009urg.2 molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc009urg.1 uc009urg.2 
ENSMUST00000112570.2 Ccnt2 ENSMUST00000112570.2 Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II). The activity of this complex is regulated by binding with 7SK snRNA (By similarity). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (PubMed:16245309, PubMed:23060074, PubMed:12037670). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (By similarity). Involved in early embryo development (PubMed:19364821). (from UniProt Q7TQK0) AK156231 CCNT2_MOUSE Ccnt2 ENSMUST00000112570.1 K4N0L9 K4N2S3 Q7TQK0 uc007cla.1 uc007cla.2 uc007cla.3 uc007cla.4 Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II). The activity of this complex is regulated by binding with 7SK snRNA (By similarity). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (PubMed:16245309, PubMed:23060074, PubMed:12037670). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (By similarity). Involved in early embryo development (PubMed:19364821). Interacts with CDK9 to form P-TEFb. Interacts with POLR2A (via the C-terminal domain (CTD)); mediates transcriptional activity. Interacts with HEXIM1; mediates formation of a tripartite complex with KPNA2. Interacts with HEXIM2. Interacts with PKN1; enhances MYOD1- dependent transcription. P-TEFB complex interacts with RB1; promotes phosphorylation of RB1 (By similarity). P-TEFB complex interacts with MYOD1; promotes the transcriptional activity of MYOD1 through its CDK9- mediated phosphorylation (PubMed:12037670). Interacts with MDFI and MDFIC (By similarity). Cytoplasm, perinuclear region Nucleus Note=Nucleus in differentiating cells. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=cyclin T2A , CycT2a ; IsoId=Q7TQK0-1; Sequence=Displayed; Name=2; Synonyms=cyclin T2B , CycT2b ; IsoId=Q7TQK0-2; Sequence=VSP_058225, VSP_058226; [Isoform 2]: Highly expressed in all phases of skeletal muscle differentiation, particularly in later stages (PubMed:23060074). Highly expressed in skeletal muscle. Significantly expressed in heart, brain, kidney, liver, testis, and pancreas (PubMed:19364821). Expressed in all forming organs and supporting tissues in 10.5 to 14.5 dpc. Expressed in embryonic ectoderm and the forming brain and neural tube in 7.5 and 8.5/9.5 dpc embryos, respectively. The homozygous knockout of Ccnt2 is embryonic lethal. Belongs to the cyclin family. Cyclin C subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity transcription coactivator binding chromatin binding protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell cycle skeletal muscle tissue development cyclin/CDK positive transcription elongation factor complex viral process cyclin-dependent protein serine/threonine kinase regulator activity early viral transcription late viral transcription protein kinase binding positive regulation of DNA-templated transcription, elongation positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm regulation of muscle cell differentiation cell division cyclin-dependent protein serine/threonine kinase activator activity RNA polymerase binding 7SK snRNA binding uc007cla.1 uc007cla.2 uc007cla.3 uc007cla.4 
ENSMUST00000112572.3 Kctd12b ENSMUST00000112572.3 Kctd12b (from geneSymbol) BC064459 ENSMUST00000112572.1 ENSMUST00000112572.2 Kctd12b Q8C7J6 Q8C7J6_MOUSE uc009uqz.1 uc009uqz.2 uc009uqz.3 molecular_function regulation of G-protein coupled receptor protein signaling pathway receptor complex protein homooligomerization uc009uqz.1 uc009uqz.2 uc009uqz.3 
ENSMUST00000112574.9 Klf8 ENSMUST00000112574.9 Kruppel-like transcription factor 8, transcript variant 1 (from RefSeq NM_173780.6) ENSMUST00000112574.1 ENSMUST00000112574.2 ENSMUST00000112574.3 ENSMUST00000112574.4 ENSMUST00000112574.5 ENSMUST00000112574.6 ENSMUST00000112574.7 ENSMUST00000112574.8 KLF8_MOUSE NM_173780 Q8BLM0 uc009uqu.1 uc009uqu.2 uc009uqu.3 Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK) (By similarity). Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, and PIAS4; the interaction with each ligase sumoylates KLF8 (By similarity). Nucleus The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF8, the motif is inactive. Sumoylation at Lys-64 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location. Belongs to the Sp1 C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus nucleoplasm cytosol regulation of transcription from RNA polymerase II promoter aggresome metal ion binding uc009uqu.1 uc009uqu.2 uc009uqu.3 
ENSMUST00000112576.4 Pdcd1lg2 ENSMUST00000112576.4 programmed cell death 1 ligand 2 (from RefSeq NM_021396.2) B7dc Btdc Cd273 ENSMUST00000112576.1 ENSMUST00000112576.2 ENSMUST00000112576.3 NM_021396 PD1L2_MOUSE Pdl2 Q9WUL5 uc008hdk.1 uc008hdk.2 uc008hdk.3 uc008hdk.4 uc008hdk.5 Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Interacts with PDCD1. Q9WUL5; Q02242: Pdcd1; NbExp=2; IntAct=EBI-15716794, EBI-5258903; Cell membrane ; Single-pass type I membrane protein Expressed in immature and mature bone marrow- derived dendritic cells and splenic dendritic cells. Highly expressed in placenta, liver and weakly expressed in heart, spleen, lymph nodes and thymus. Also expressed in some tumor cell lines of lymphoid origin. Belongs to the immunoglobulin superfamily. BTN/MOG family. adaptive immune response immune system process protein binding plasma membrane immune response signal transduction cell surface receptor signaling pathway external side of plasma membrane cell surface membrane integral component of membrane T cell costimulation negative regulation of interferon-gamma production negative regulation of interleukin-10 production positive regulation of T cell proliferation negative regulation of T cell proliferation negative regulation of activated T cell proliferation cellular response to lipopolysaccharide uc008hdk.1 uc008hdk.2 uc008hdk.3 uc008hdk.4 uc008hdk.5 
ENSMUST00000112586.8 Apobec1 ENSMUST00000112586.8 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1, transcript variant 1 (from RefSeq NM_031159.4) Apobec1 ENSMUST00000112586.1 ENSMUST00000112586.2 ENSMUST00000112586.3 ENSMUST00000112586.4 ENSMUST00000112586.5 ENSMUST00000112586.6 ENSMUST00000112586.7 NM_031159 Q3U9G8 Q3U9G8_MOUSE uc009dpk.1 uc009dpk.2 Reaction=a cytidine in mRNA + H(+) + H2O = a uridine in mRNA + NH4(+); Xref=Rhea:RHEA:74355, Rhea:RHEA-COMP:14658, Rhea:RHEA-COMP:15145, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:65315, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74356; Evidence=; Reaction=cytidine(6666) in apoB mRNA + H(+) + H2O = NH4(+) + uridine(6666) in apoB mRNA; Xref=Rhea:RHEA:21772, Rhea:RHEA- COMP:13888, Rhea:RHEA-COMP:13889, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:65315, ChEBI:CHEBI:82748; EC=3.5.4.36; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21773; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Cytoplasm Nucleus Belongs to the cytidine and deoxycytidylate deaminase family. mRNA binding catalytic activity cytidine deaminase activity cytosine deaminase activity nucleus cytoplasm response to osmotic stress enzyme activator activity zinc ion binding cytidine deamination response to zinc ion cytidine to uridine editing mRNA modification hydrolase activity protein domain specific binding cellular response to insulin stimulus response to drug ribonucleoprotein complex binding positive regulation of catalytic activity response to ethanol response to calcium ion defense response to virus DNA cytosine deamination positive regulation of mRNA modification uc009dpk.1 uc009dpk.2 
ENSMUST00000112588.9 Kdm5c ENSMUST00000112588.9 lysine demethylase 5C, transcript variant 1 (from RefSeq NM_013668.5) ENSMUST00000112588.1 ENSMUST00000112588.2 ENSMUST00000112588.3 ENSMUST00000112588.4 ENSMUST00000112588.5 ENSMUST00000112588.6 ENSMUST00000112588.7 ENSMUST00000112588.8 Jarid1c KDM5C_MOUSE Kiaa0234 NM_013668 O54995 P41230 Q3TYU8 Q3U1X6 Q3U282 Q6ZQF8 Q80XQ9 Q9CVI4 Q9D0C3 Q9QVR8 Q9R039 Smcx Xe169 uc009uqc.1 uc009uqc.2 uc009uqc.3 uc009uqc.4 uc009uqc.5 uc009uqc.6 Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (By similarity). Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. Reaction=3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)- [histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate; Xref=Rhea:RHEA:60208, Rhea:RHEA-COMP:15537, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61961; EC=1.14.11.67; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Part of two distinct complexes, one containing E2F6, and the other containing REST. Interacts with ZMYND8. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P41230-1; Sequence=Displayed; Name=2; IsoId=P41230-2; Sequence=VSP_000316; Name=3; IsoId=P41230-3; Sequence=VSP_026411, VSP_000316; The first PHD-type zinc finger domain recognizes and binds H3- K9Me3. Both the JmjC domain and the JmjN domain are required for enzymatic activity. Escapes X-inactivation. Belongs to the JARID1 histone demethylase family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding DNA binding nucleus nucleoplasm cytoplasm cytosol chromatin organization chromatin remodeling zinc ion binding oxidoreductase activity histone demethylase activity histone demethylase activity (H3-K4 specific) histone demethylase activity (H3-trimethyl-K4 specific) histone H3-K4 demethylation histone H3-K4 demethylation, trimethyl-H3-K4-specific histone methyltransferase complex regulation of circadian rhythm identical protein binding negative regulation of transcription, DNA-templated metal ion binding rhythmic process dioxygenase activity oxidation-reduction process uc009uqc.1 uc009uqc.2 uc009uqc.3 uc009uqc.4 uc009uqc.5 uc009uqc.6 
ENSMUST00000112601.9 Acvr1 ENSMUST00000112601.9 activin A receptor, type 1, transcript variant 2 (from RefSeq NM_007394.3) ACVR1_MOUSE Acvrlk2 ENSMUST00000112601.1 ENSMUST00000112601.2 ENSMUST00000112601.3 ENSMUST00000112601.4 ENSMUST00000112601.5 ENSMUST00000112601.6 ENSMUST00000112601.7 ENSMUST00000112601.8 NM_007394 P37172 Q3UDH5 Q91VF1 Tgfb1 uc008jss.1 uc008jss.2 uc008jss.3 Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation (PubMed:10479450, PubMed:15531373, PubMed:21945937). As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A ors ACVR2B. Upon binding of ligands such as BMP7 or BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (PubMed:25413979, PubMed:10479450, PubMed:15531373, PubMed:21945937) (By similarity). May promote the expression of HAMP, potentially via its interaction with BMP6 (PubMed:31800957). Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA- COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Interacts with FKBP1A (By similarity). Interacts with FCHO1 (By similarity). Interacts with CLU. Interacts with type II receptors AMHR2 and ACVR2A (By similarity). Interacts with BMP7 (By similarity). Interacts with BMP9 (By similarity). Interacts with BMP6 (when glycosylated); the interaction may induce HAMP expression (PubMed:31800957). Interacts with TSC22D1/TSC-22 (By similarity). Membrane; Single-pass type I membrane protein. Highly expressed in bone during developmental stages (PubMed:21945937). Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Highly expressed in the node and midline and weakly expressed in 8.5 dpc embryos and in the lateral plate mesoderm. Deletion mutants show a recessive embryonic lethality. At 7.0 dpc, mutant embryos did not show any special abnormalities except a smaller size. However, at 8.0 dpc, mesoderm formation is initiated but its development is arrested around the mid/late streak stage (PubMed:10479450). In an osteoblast-specific manner loss of BMP signaling via ACVR1 directs osteoblasts to increase endogenous bone mass (PubMed:21945937). Additionally, mice lacking ACVR1 in cartilage show reduced SMAD responses, but also decreased p38 MAPK activation (PubMed:25413979). Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. G1/S transition of mitotic cell cycle nucleotide binding branching involved in blood vessel morphogenesis urogenital system development in utero embryonic development gastrulation with mouth forming second mesoderm formation neural crest cell migration acute inflammatory response embryonic heart tube morphogenesis atrioventricular valve morphogenesis mitral valve morphogenesis endocardial cushion morphogenesis endocardial cushion fusion atrial septum primum morphogenesis protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I protein binding ATP binding integral component of plasma membrane protein phosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway germ cell development determination of left/right symmetry gastrulation pattern specification process mesoderm development heart development negative regulation of signal transduction positive regulation of pathway-restricted SMAD protein phosphorylation membrane integral component of membrane kinase activity phosphorylation activin receptor activity, type I transferase activity peptidyl-threonine phosphorylation growth factor binding regulation of ossification positive regulation of cell migration positive regulation of bone mineralization BMP signaling pathway activin receptor signaling pathway negative regulation of activin receptor signaling pathway protein homodimerization activity receptor complex apical part of cell cadherin binding positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter SMAD binding metal ion binding activin receptor complex activin binding transforming growth factor beta binding positive regulation of peptidyl-tyrosine phosphorylation smooth muscle cell differentiation pharyngeal system development pathway-restricted SMAD protein phosphorylation ventricular septum morphogenesis cardiac muscle cell fate commitment BMP signaling pathway involved in heart development endocardial cushion cell fate commitment cellular response to BMP stimulus BMP receptor activity positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation protein tyrosine kinase binding positive regulation of determination of dorsal identity negative regulation of extrinsic apoptotic signaling pathway outflow tract septum morphogenesis uc008jss.1 uc008jss.2 uc008jss.3 
ENSMUST00000112605.8 Iqsec2 ENSMUST00000112605.8 Cytoplasm (from UniProt E9QAD8) AB275281 E9QAD8 E9QAD8_MOUSE ENSMUST00000112605.1 ENSMUST00000112605.2 ENSMUST00000112605.3 ENSMUST00000112605.4 ENSMUST00000112605.5 ENSMUST00000112605.6 ENSMUST00000112605.7 Iqsec2 uc292rgd.1 uc292rgd.2 Cytoplasm Belongs to the BRAG family. ARF guanyl-nucleotide exchange factor activity regulation of ARF protein signal transduction uc292rgd.1 uc292rgd.2 
ENSMUST00000112606.8 Dpp10 ENSMUST00000112606.8 dipeptidylpeptidase 10, transcript variant 1 (from RefSeq NM_199021.4) Dpp10 E9QN98 E9QN98_MOUSE ENSMUST00000112606.1 ENSMUST00000112606.2 ENSMUST00000112606.3 ENSMUST00000112606.4 ENSMUST00000112606.5 ENSMUST00000112606.6 ENSMUST00000112606.7 NM_199021 uc007cjx.1 uc007cjx.2 uc007cjx.3 uc007cjx.4 proteolysis voltage-gated potassium channel complex serine-type peptidase activity membrane integral component of membrane ion channel binding positive regulation of protein localization to plasma membrane uc007cjx.1 uc007cjx.2 uc007cjx.3 uc007cjx.4 
ENSMUST00000112610.2 M6pr ENSMUST00000112610.2 M6pr (from geneSymbol) AK153302 ENSMUST00000112610.1 M6pr Q3UKQ5 Q3UKQ5_MOUSE uc291ioa.1 uc291ioa.2 endosome Golgi apparatus protein targeting to lysosome membrane integral component of membrane protein domain specific binding perinuclear region of cytoplasm retromer complex binding uc291ioa.1 uc291ioa.2 
ENSMUST00000112629.8 Nr4a2 ENSMUST00000112629.8 nuclear receptor subfamily 4, group A, member 2, transcript variant 2 (from RefSeq NM_001139509.2) ENSMUST00000112629.1 ENSMUST00000112629.2 ENSMUST00000112629.3 ENSMUST00000112629.4 ENSMUST00000112629.5 ENSMUST00000112629.6 ENSMUST00000112629.7 NM_001139509 Nr4a2 Q3TYI4 Q3TYI4_MOUSE uc008jry.1 uc008jry.2 uc008jry.3 uc008jry.4 Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2. Cytoplasm Nucleus Belongs to the nuclear hormone receptor family. NR4 subfamily. negative regulation of transcription from RNA polymerase II promoter DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding nucleus transcription, DNA-templated regulation of transcription, DNA-templated zinc ion binding nuclear speck intracellular receptor signaling pathway cellular response to extracellular stimulus steroid hormone mediated signaling pathway sequence-specific DNA binding metal ion binding negative regulation of apoptotic signaling pathway uc008jry.1 uc008jry.2 uc008jry.3 uc008jry.4 
ENSMUST00000112636.8 Galnt13 ENSMUST00000112636.8 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor (PubMed:12407114, PubMed:8618846, PubMed:27629416). Generates GalNAc-O-Ser/Thr structure also known as Tn antigen, which itself is immunogenic but also serves as a precursor for the synthesis of different mucin-type O-glycan core structures (PubMed:12407114). Contributes to the synthesis of O-linked glycans on mucins and proteoglycans of the central nervous system (PubMed:12407114, PubMed:27629416). Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC. Transfers GalNAc to three consecutive serine/threonine residues on SDC3 forming a triplet-Tn epitope expressed in Purkinje cells of the developing brain (By similarity). May promote neurogenesis through glycosylation and stabilization of PDPN (PubMed:27629416). (from UniProt Q8CF93) BC131652 ENSMUST00000112636.1 ENSMUST00000112636.2 ENSMUST00000112636.3 ENSMUST00000112636.4 ENSMUST00000112636.5 ENSMUST00000112636.6 ENSMUST00000112636.7 GLT13_MOUSE Q8BLE4 Q8BYT3 Q8CF93 uc008jrr.1 uc008jrr.2 uc008jrr.3 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor (PubMed:12407114, PubMed:8618846, PubMed:27629416). Generates GalNAc-O-Ser/Thr structure also known as Tn antigen, which itself is immunogenic but also serves as a precursor for the synthesis of different mucin-type O-glycan core structures (PubMed:12407114). Contributes to the synthesis of O-linked glycans on mucins and proteoglycans of the central nervous system (PubMed:12407114, PubMed:27629416). Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC. Transfers GalNAc to three consecutive serine/threonine residues on SDC3 forming a triplet-Tn epitope expressed in Purkinje cells of the developing brain (By similarity). May promote neurogenesis through glycosylation and stabilization of PDPN (PubMed:27629416). Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Evidence=; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CF93-1; Sequence=Displayed; Name=2; IsoId=Q8CF93-2; Sequence=VSP_011220; Specifically expressed in neuronal cells. Not expressed in glial cells such as astrocytes. Expressed at low level. Expressed at high levels in the developing brain, reaching a peak at 17.5 dpc, followed by a decrease at 19.5 dpc. Highly expressed during the postnatal period. Expressed in cortical neural precursor cells at 17.5 dpc. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. No visible phenotype. It however abolishes Tn antigen in neuronal cells. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Was initially wrongly assigned as Galnt8. Name=Functional Glycomics Gateway - GTase; Note=Polypeptide N-acetylgalactosaminyltransferase 13; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_521"; Golgi membrane polypeptide N-acetylgalactosaminyltransferase activity Golgi apparatus protein glycosylation protein O-linked glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via serine protein O-linked glycosylation via threonine carbohydrate binding metal ion binding uc008jrr.1 uc008jrr.2 uc008jrr.3 
ENSMUST00000112641.8 Steap3 ENSMUST00000112641.8 STEAP family member 3, transcript variant 1 (from RefSeq NM_001085409.2) A0A0R4J1G9 A0A0R4J1G9_MOUSE ENSMUST00000112641.1 ENSMUST00000112641.2 ENSMUST00000112641.3 ENSMUST00000112641.4 ENSMUST00000112641.5 ENSMUST00000112641.6 ENSMUST00000112641.7 NM_001085409 Steap3 uc007cjj.1 uc007cjj.2 uc007cjj.3 Reaction=2 Cu(+) + H(+) + NADP(+) = 2 Cu(2+) + NADPH; Xref=Rhea:RHEA:71771, ChEBI:CHEBI:15378, ChEBI:CHEBI:29036, ChEBI:CHEBI:49552, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71773; Evidence=; Reaction=2 Fe(2+) + H(+) + NADP(+) = 2 Fe(3+) + NADPH; Xref=Rhea:RHEA:71767, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71769; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Endosome membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the STEAP family. cytoplasm multivesicular body protein secretion membrane integral component of membrane uc007cjj.1 uc007cjj.2 uc007cjj.3 
ENSMUST00000112642.8 Evi5 ENSMUST00000112642.8 ecotropic viral integration site 5, transcript variant 1 (from RefSeq NM_007964.2) ENSMUST00000112642.1 ENSMUST00000112642.2 ENSMUST00000112642.3 ENSMUST00000112642.4 ENSMUST00000112642.5 ENSMUST00000112642.6 ENSMUST00000112642.7 Evi5 F8VPT6 F8VPT6_MOUSE NM_007964 uc008ynb.1 uc008ynb.2 GTPase activator activity Golgi apparatus cytosol Rab GTPase binding retrograde transport, endosome to Golgi regulation of GTPase activity intracellular membrane-bounded organelle positive regulation of GTPase activity uc008ynb.1 uc008ynb.2 
ENSMUST00000112644.9 3110009E18Rik ENSMUST00000112644.9 RIKEN cDNA 3110009E18 gene, transcript variant 1 (from RefSeq NM_028439.2) CB076_MOUSE ENSMUST00000112644.1 ENSMUST00000112644.2 ENSMUST00000112644.3 ENSMUST00000112644.4 ENSMUST00000112644.5 ENSMUST00000112644.6 ENSMUST00000112644.7 ENSMUST00000112644.8 NM_028439 Q8K163 Q9CRW3 uc007cjh.1 uc007cjh.2 uc007cjh.3 uc007cjh.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CRW3-1; Sequence=Displayed; Name=2; IsoId=Q9CRW3-2; Sequence=VSP_032430; Belongs to the UPF0538 family. molecular_function cellular_component biological_process uc007cjh.1 uc007cjh.2 uc007cjh.3 uc007cjh.4 
ENSMUST00000112645.8 Trf ENSMUST00000112645.8 Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. (from UniProt Q921I1) AK142599 ENSMUST00000112645.1 ENSMUST00000112645.2 ENSMUST00000112645.3 ENSMUST00000112645.4 ENSMUST00000112645.5 ENSMUST00000112645.6 ENSMUST00000112645.7 O35421 Q3UBW7 Q58E69 Q61803 Q62357 Q62358 Q62359 Q63915 Q64515 Q8VII5 Q921I1 Q922C0 TRFE_MOUSE Tf uc292kek.1 uc292kek.2 Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Monomer. Secreted. Expressed by the liver and secreted in plasma. Belongs to the transferrin family. protein binding extracellular region basement membrane extracellular space endosome early endosome late endosome clathrin-coated pit ion transport iron ion transport cellular iron ion homeostasis actin filament organization activation of JUN kinase activity ferrous iron binding ferric iron binding response to bacterium basal plasma membrane cell surface ferric iron transmembrane transporter activity membrane apical plasma membrane vesicle coat endocytic vesicle osteoclast differentiation extrinsic component of external side of plasma membrane cytoplasmic vesicle positive regulation of myelination vesicle iron ion transmembrane transport regulation of iron ion transport iron chaperone activity positive regulation of phosphorylation basal part of cell positive regulation of bone resorption positive regulation of transcription, DNA-templated metal ion binding positive regulation of receptor-mediated endocytosis perinuclear region of cytoplasm cell tip recycling endosome iron ion homeostasis SMAD protein signal transduction ERK1 and ERK2 cascade positive regulation of oligodendrocyte progenitor proliferation cellular response to iron ion trivalent inorganic cation transport dense body transferrin receptor binding HFE-transferrin receptor complex positive regulation of cell motility uc292kek.1 uc292kek.2 
ENSMUST00000112652.9 Gm11100 ENSMUST00000112652.9 predicted gene 11100 (from RefSeq NM_001370907.1) A0A5F8MPS3 A0A5F8MPS3_MOUSE ENSMUST00000112652.1 ENSMUST00000112652.2 ENSMUST00000112652.3 ENSMUST00000112652.4 ENSMUST00000112652.5 ENSMUST00000112652.6 ENSMUST00000112652.7 ENSMUST00000112652.8 Gm11100 NM_001370907 uc288qvp.1 uc288qvp.2 uc288qvp.3 uc288qvp.1 uc288qvp.2 uc288qvp.3 
ENSMUST00000112658.8 Cadps ENSMUST00000112658.8 Ca2+-dependent secretion activator, transcript variant 5 (from RefSeq NM_001359921.1) CAPS1_MOUSE Caps Caps1 E9QN90 ENSMUST00000112658.1 ENSMUST00000112658.2 ENSMUST00000112658.3 ENSMUST00000112658.4 ENSMUST00000112658.5 ENSMUST00000112658.6 ENSMUST00000112658.7 Kiaa1121 NM_001359921 Q3TSP2 Q61374 Q6AXB4 Q6PGF0 Q80TJ1 uc007sfu.1 uc007sfu.2 uc007sfu.3 Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2- binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). Homodimer. Interacts with the dopamine receptor DRD2 (By similarity). Interacts with RASL10B. Synapse Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane ; Peripheral membrane protein Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to dense core vesicles but not to synaptic vesicles. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80TJ1-1; Sequence=Displayed; Name=2; IsoId=Q80TJ1-2; Sequence=VSP_016809, VSP_016811, VSP_016813; Name=4; IsoId=Q80TJ1-4; Sequence=VSP_016814; Present in brain and adrenal glands (at protein level). Specifically expressed in neural and endocrine secretory tissues. Strongly expressed in almost all nerve cells of the brain, although it is absent from glial cells. Expressed in the cardiac atria, but not ventricles. During brain development, its expression is similar to that of synaptic markers. Expression is first detectable late in embryogenesis (14 dpc) and increases to reach a plateau about 20 days after birth, when most synapses have been formed (at protein level). In the heart, up-regulated by hypertrophic stimuli. The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however does not mediate binding to DCVs (By similarity). Mice die within 30 minutes after birth but do not display obvious developmental or biochemical abnormalities. They show a strong reduction in the frequency of amperometrically detectable release events of transmitter-filled vesicles, while the total number of fusing vesicles, as judged by capacitance recordings or total internal reflection microscopy, remains unchanged. Sequence=BAA13044.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due to a duplication of 90 bp after position 107.; Evidence=; Sequence=BAC65735.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; calcium ion binding protein binding phosphatidylinositol-4,5-bisphosphate binding exocytosis lipid binding protein transport membrane vesicle organization synaptic vesicle exocytosis synaptic vesicle priming protein kinase binding cell junction cytoplasmic vesicle membrane dense core granule cytoplasmic vesicle synapse positive regulation of exocytosis positive regulation of calcium ion-dependent exocytosis metal ion binding catecholamine secretion presynapse glutamatergic synapse presynaptic dense core vesicle exocytosis dense core granule exocytosis uc007sfu.1 uc007sfu.2 uc007sfu.3 
ENSMUST00000112674.8 Zbtb14 ENSMUST00000112674.8 zinc finger and BTB domain containing 14, transcript variant 3 (from RefSeq NM_001356283.1) ENSMUST00000112674.1 ENSMUST00000112674.2 ENSMUST00000112674.3 ENSMUST00000112674.4 ENSMUST00000112674.5 ENSMUST00000112674.6 ENSMUST00000112674.7 NM_001356283 Q544H8 Q544H8_MOUSE Zbtb14 Zfp161 uc289mno.1 uc289mno.2 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm nucleolus cytosol aggresome sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated uc289mno.1 uc289mno.2 
ENSMUST00000112682.4 Slc25a18 ENSMUST00000112682.4 solute carrier family 25 (mitochondrial carrier), member 18, transcript variant 3 (from RefSeq NM_001417736.1) B2RPU3 ENSMUST00000112682.1 ENSMUST00000112682.2 ENSMUST00000112682.3 GHC2_MOUSE Gc2 NM_001417736 Q14AI5 Q9DB41 uc009dnq.1 uc009dnq.2 uc009dnq.3 Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system). Reaction=H(+)(in) + L-glutamate(in) = H(+)(out) + L-glutamate(out); Xref=Rhea:RHEA:70955, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DB41-1; Sequence=Displayed; Name=2; IsoId=Q9DB41-2; Sequence=VSP_022262; [Isoform 2]: Incomplete sequence. Belongs to the mitochondrial carrier (TC 2.A.29) family. L-glutamate transmembrane transporter activity mitochondrion mitochondrial inner membrane L-aspartate transmembrane transporter activity symporter activity aspartate transport L-glutamate transport membrane integral component of membrane transmembrane transporter activity malate-aspartate shuttle transmembrane transport L-aspartate transport uc009dnq.1 uc009dnq.2 uc009dnq.3 
ENSMUST00000112683.9 Tsr2 ENSMUST00000112683.9 TSR2 20S rRNA accumulation, transcript variant 2 (from RefSeq NM_175146.4) ENSMUST00000112683.1 ENSMUST00000112683.2 ENSMUST00000112683.3 ENSMUST00000112683.4 ENSMUST00000112683.5 ENSMUST00000112683.6 ENSMUST00000112683.7 ENSMUST00000112683.8 NM_175146 Tsr2 Z4YL87 Z4YL87_MOUSE uc009uox.1 uc009uox.2 uc009uox.3 May be involved in 20S pre-rRNA processing. Belongs to the TSR2 family. uc009uox.1 uc009uox.2 uc009uox.3 
ENSMUST00000112691.9 Gnl3l ENSMUST00000112691.9 guanine nucleotide binding protein nucleolar 3 like, transcript variant 1 (from RefSeq NM_198110.2) ENSMUST00000112691.1 ENSMUST00000112691.2 ENSMUST00000112691.3 ENSMUST00000112691.4 ENSMUST00000112691.5 ENSMUST00000112691.6 ENSMUST00000112691.7 ENSMUST00000112691.8 GNL3L_MOUSE NM_198110 Q6PGG6 uc009uou.1 uc009uou.2 uc009uou.3 uc009uou.4 Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity). Interacts with MDM2; this interaction, which occurs in the nucleoplasm, stabilizes MDM2. Indirectly interacts with TP53, via MDM2- binding. Interacts with TERF1; this interaction probably occurs in the nucleoplasm and is increased during mitosis, when the nucleolus is disassembled. This binding may promote TERF1 homodimerization. Interacts with TERT. Nucleus, nucleolus In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern. Belongs to the TRAFAC class YlqF/YawG GTPase family. nucleotide binding GTP binding nucleus telomerase holoenzyme complex nucleolus cytosol negative regulation of protein ubiquitination regulation of protein stability negative regulation of protein binding negative regulation of telomere maintenance via telomerase negative regulation of protein sumoylation ribosome biogenesis positive regulation of protein homodimerization activity positive regulation of protein localization to chromosome, telomeric region uc009uou.1 uc009uou.2 uc009uou.3 uc009uou.4 
ENSMUST00000112693.10 Rif1 ENSMUST00000112693.10 replication timing regulatory factor 1, transcript variant 1 (from RefSeq NM_175238.6) ENSMUST00000112693.1 ENSMUST00000112693.2 ENSMUST00000112693.3 ENSMUST00000112693.4 ENSMUST00000112693.5 ENSMUST00000112693.6 ENSMUST00000112693.7 ENSMUST00000112693.8 ENSMUST00000112693.9 NM_175238 Q6PR54 Q6T8D9 Q7TPD8 Q8BTU2 Q8C408 Q9CS77 RIF1_MOUSE Rif1 uc008jqq.1 uc008jqq.2 uc008jqq.3 Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:23333305, PubMed:23306437, PubMed:23306439). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333305, PubMed:23306437, PubMed:23306439). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333305, PubMed:23306437). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333305, PubMed:23306437). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23333305, PubMed:23333306, PubMed:23306439). Promotes NHEJ of dysfunctional telomeres (PubMed:23333305). Interacts with TP53BP1 (when phosphorylated by ATM) (PubMed:23333305, PubMed:23306437, PubMed:23306439). May interact with TRF2 (PubMed:15042697). Interacts with SHLD2 (By similarity). Interacts with ERCC6 (via WHD region) (By similarity). Q6PR54; Q80Z64: Nanog; NbExp=5; IntAct=EBI-2312621, EBI-2312517; Q6PR54; Q61066: Nr0b1; NbExp=2; IntAct=EBI-2312621, EBI-2312665; Nucleus Chromosome romosome, telomere Cytoplasm, cytoskeleton, spindle Note=Exhibits ATM- and TP53BP1- dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Following interaction with TP53BP1, recruited to sites of DNA damage, such as DSBs (PubMed:23333305, PubMed:23306437, PubMed:23306439). Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase (By similarity). While the majority of the protein appears nuclear and distinct from normal telomere structures, a small fraction may bind to telomeres in embryonic stem cells (PubMed:15042697). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PR54-1; Sequence=Displayed; Name=2; IsoId=Q6PR54-2; Sequence=VSP_014433; Name=3; IsoId=Q6PR54-3; Sequence=VSP_014432; Expressed in Sertoli cells, prospermatagonia, early primary spermatocytes, and in oocytes at all stages of their growth. Expressed in embryonic stem (ES) and embryonic germ (EG) cells: expression is lost upon differentiation. Found in the nucleus of germinal-vesicle (GV) stage oocytes prior to fertilization. Accumulates in the male and female pronucleus after fertilization. Expressed in the nuclei of all blastomeres from the two cell stage to the compacted morula stage, although absent from the polar body and inner cell mass (ICM). Found in the nuclei of polar and mural trophectoderm cells from 3.5 dpc, and at high levels in the epiblast from 5.5 dpc to 7.5 dpc. Expressed by primitive germ cells (PGCs) in both male and female from 9.5 dpc to 13.5 dpc, at which point expression declines. A low level is observed in Sertoli cells of the testis at 17.5 dpc. Embryonic lethality in inbred 129/Ola and outbred MF1 mouse strains: 7.5 dpc embryos display significant developmental retardation (PubMed:23333305). Female-specific lethality in a CD1 strain background, while males survive (PubMed:23333305). Surviving males grow normally, are fertile, but are subject to infections due to defects in the immune response (PubMed:23333305). Surviving males are severely compromised for TP53BP1-dependent class-switch recombination (CSR) and fusion of dysfunctional telomeres (PubMed:23333305). [Isoform 3]: May be due to a competing acceptor splice site. Belongs to the RIF1 family. Sequence=BAB30843.1; Type=Erroneous initiation; Evidence=; Sequence=BAC38846.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence=; Sequence=BAC40506.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; negative regulation of transcription from RNA polymerase II promoter telomere maintenance chromosome, telomeric region nuclear chromatin condensed chromosome female pronucleus male pronucleus protein binding nucleus chromosome cytoplasm spindle cytoskeleton plasma membrane DNA repair chromatin silencing at telomere cellular response to DNA damage stimulus cell cycle nuclear body stem cell population maintenance nuclear membrane site of double-strand break telomere maintenance in response to DNA damage positive regulation of isotype switching spindle midzone positive regulation of histone H3-K9 methylation cellular response to leukemia inhibitory factor negative regulation of double-strand break repair via homologous recombination positive regulation of double-strand break repair via nonhomologous end joining uc008jqq.1 uc008jqq.2 uc008jqq.3 
ENSMUST00000112696.8 Zfp644 ENSMUST00000112696.8 Nucleus (from UniProt E9QA22) BC057405 E9QA22 E9QA22_MOUSE ENSMUST00000112696.1 ENSMUST00000112696.2 ENSMUST00000112696.3 ENSMUST00000112696.4 ENSMUST00000112696.5 ENSMUST00000112696.6 ENSMUST00000112696.7 Zfp644 uc008ylp.1 uc008ylp.2 uc008ylp.3 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated uc008ylp.1 uc008ylp.2 uc008ylp.3 
ENSMUST00000112699.9 Maged2 ENSMUST00000112699.9 MAGE family member D2, transcript variant 1 (from RefSeq NM_030700.3) ENSMUST00000112699.1 ENSMUST00000112699.2 ENSMUST00000112699.3 ENSMUST00000112699.4 ENSMUST00000112699.5 ENSMUST00000112699.6 ENSMUST00000112699.7 ENSMUST00000112699.8 Maged2 NM_030700 Q9ER67 Q9ER67_MOUSE uc009uot.1 uc009uot.2 uc009uot.3 uc009uot.4 molecular_function nucleus nucleolus cytosol female pregnancy renal sodium ion absorption uc009uot.1 uc009uot.2 uc009uot.3 uc009uot.4 
ENSMUST00000112701.8 Cdh7 ENSMUST00000112701.8 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). (from UniProt Q8BM92) BC083189 CADH7_MOUSE ENSMUST00000112701.1 ENSMUST00000112701.2 ENSMUST00000112701.3 ENSMUST00000112701.4 ENSMUST00000112701.5 ENSMUST00000112701.6 ENSMUST00000112701.7 Q3UVE2 Q67G09 Q8BM92 uc007chw.1 uc007chw.2 uc007chw.3 uc007chw.4 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). Cell membrane ; Single-pass type I membrane protein Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. cell morphogenesis calcium ion binding plasma membrane cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cytoskeletal protein binding cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex adherens junction organization protein homodimerization activity cell-cell adhesion mediated by cadherin cadherin binding metal ion binding cell-cell adhesion uc007chw.1 uc007chw.2 uc007chw.3 uc007chw.4 
ENSMUST00000112706.4 Serpinb8 ENSMUST00000112706.4 serine (or cysteine) peptidase inhibitor, clade B, member 8, transcript variant 2 (from RefSeq NM_001159748.1) ENSMUST00000112706.1 ENSMUST00000112706.2 ENSMUST00000112706.3 NM_001159748 O08800 SPB8_MOUSE uc007chs.1 uc007chs.2 uc007chs.3 uc007chs.4 Has an important role in epithelial desmosome-mediated cell- cell adhesion. Cytoplasm Belongs to the serpin family. Ov-serpin subfamily. serine-type endopeptidase inhibitor activity extracellular space cytoplasm cytosol negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity epithelial cell-cell adhesion uc007chs.1 uc007chs.2 uc007chs.3 uc007chs.4 
ENSMUST00000112707.3 Lrrc8b ENSMUST00000112707.3 leucine rich repeat containing 8 family, member B (from RefSeq NM_001033550.4) B2RSI6 ENSMUST00000112707.1 ENSMUST00000112707.2 Kiaa0231 LRC8B_MOUSE Lrrc8b NM_001033550 Q5DU41 uc008yle.1 uc008yle.2 uc008yle.3 Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324, ChEBI:CHEBI:16382; Evidence=; Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328, ChEBI:CHEBI:507393; Evidence=; Heterohexamer. Oligomerizes with other LRRC8 proteins (LRRC8A, LRRC8C, LRRC8D and/or LRRC8E) to form a heterohexamer (PubMed:24782309). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable). Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5DU41-1; Sequence=Displayed; Name=2; IsoId=Q5DU41-2; Sequence=VSP_055395; The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins. Belongs to the LRRC8 family. Sequence=BAD90398.1; Type=Erroneous initiation; Evidence=; volume-sensitive anion channel activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane ion transport inorganic anion transport membrane integral component of membrane ion channel complex anion transmembrane transport uc008yle.1 uc008yle.2 uc008yle.3 
ENSMUST00000112711.9 Ninj2 ENSMUST00000112711.9 ninjurin 2, transcript variant 1 (from RefSeq NM_016718.3) ENSMUST00000112711.1 ENSMUST00000112711.2 ENSMUST00000112711.3 ENSMUST00000112711.4 ENSMUST00000112711.5 ENSMUST00000112711.6 ENSMUST00000112711.7 ENSMUST00000112711.8 NINJ2_MOUSE NM_016718 Q9JL89 uc009dmx.1 uc009dmx.2 uc009dmx.3 Effector of necroptotic and pyroptotic programmed cell death that mediates plasma membrane rupture (cytolysis). Acts downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively: oligomerizes in response to death stimuli and promotes plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane, leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Also acts as a homophilic transmembrane adhesion molecule involved in nerve regeneration. Promotes axonal growth (By similarity). In normal conditions, NINJ2 is inactivated. In response to death stimuli, homooligomerizes and disrupts membrane integrity by introducing the hydrophilic faces of alpha1 and alpha2 helices into the hydrophobic membrane. Membrane; Multi-pass membrane protein. In the dorsal root ganglia, already detected at embryonic day 14, increasing until postnatal day 2 where the adult level is reached. By nerve injury; in Schwann cells. Composed of 4 alpha helices: 2 hydrophobic transmembrane regions (alpha3 and alpha4) and 2 alpha helices (alpha1 and alpha2). Alpha1 and alpha2 feature one hydrophobic side and a hydrophilic side. In normal conditions, NINJ2 is inactivated and alpha1 and alpha2 helices are not inserted into the membrane. Following NINJ2 activation, alpha1 and alpha2 helices insert into the membrane and drive NINJ2 oligomerization via interactions between alpha3 and alpha4 and the hydrophobic face of alpha1 from an adjacent subunit. Such structures disrupt membrane integrity and form a lesion through the introduction of the hydrophilic faces of alpha1 and alpha2 into the hydrophobic membrane. Belongs to the ninjurin family. cell adhesion membrane integral component of membrane tissue regeneration uc009dmx.1 uc009dmx.2 uc009dmx.3 
ENSMUST00000112712.10 Lypd6 ENSMUST00000112712.10 LY6/PLAUR domain containing 6, transcript variant 1 (from RefSeq NM_177139.6) ENSMUST00000112712.1 ENSMUST00000112712.2 ENSMUST00000112712.3 ENSMUST00000112712.4 ENSMUST00000112712.5 ENSMUST00000112712.6 ENSMUST00000112712.7 ENSMUST00000112712.8 ENSMUST00000112712.9 LYPD6_MOUSE NM_177139 Q8BPP5 uc012bvg.1 uc012bvg.2 uc012bvg.3 Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain (PubMed:19403274). Inhibits nicotine- induced Ca(2+) influx through nAChRs (By similarity). In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner (By similarity). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). Interacts with nicotinic acetylcholine receptors (nAChRs) including CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNB2 and CHRNB4 (By similarity). Interacts (via NxI motif) with LRP6 (By similarity). Secreted Cytoplasm Cell membrane ; Lipid-anchor, GPI-anchor Synapse, synaptosome Membrane raft Cell projection, dendrite Perikaryon Note=Colocalizes with alpha-3:beta- 4- and alpha-7- nicotinic acetylcholine receptors (nAChRs) in the primary cortex and hippocampus. Detected in the frontal cortex and hippocampus (at protein level) (PubMed:25680266). Highly expressed in the brain and spinal cord, as well as dorsal root and trigeminal ganglia (PubMed:19403274). The UPAR/Ly6 domain is sufficient for inhibiting alpha-3:beta-4 and alpha-7-dependent nAChR currents. cellular_component extracellular region cytoplasm plasma membrane membrane cell junction acetylcholine receptor regulator activity acetylcholine receptor inhibitor activity anchored component of membrane neuron projection membrane raft synapse positive regulation of canonical Wnt signaling pathway regulation of neurotransmitter receptor activity negative regulation of receptor activity uc012bvg.1 uc012bvg.2 uc012bvg.3 
ENSMUST00000112713.3 Pfkfb1 ENSMUST00000112713.3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1, transcript variant 1 (from RefSeq NM_001374173.1) A2AFN0 ENSMUST00000112713.1 ENSMUST00000112713.2 F261_MOUSE NM_001374173 P70266 Pfkfb1 Q3V180 uc292rcm.1 uc292rcm.2 Synthesis and degradation of fructose 2,6-bisphosphate. Reaction=beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate; Xref=Rhea:RHEA:17289, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634, ChEBI:CHEBI:58579; EC=3.1.3.46; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17290; Evidence=; Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6- bisphosphate + H(+); Xref=Rhea:RHEA:15653, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57634, ChEBI:CHEBI:58579, ChEBI:CHEBI:456216; EC=2.7.1.105; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15654; Evidence=; Phosphorylation at Ser-33 inhibits the kinase and activates the bisphosphatase. Homodimer. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70266-1; Sequence=Displayed; Name=2; IsoId=P70266-2; Sequence=VSP_022168; Liver. In the C-terminal section; belongs to the phosphoglycerate mutase family. nucleotide binding catalytic activity 6-phosphofructo-2-kinase activity fructose-2,6-bisphosphate 2-phosphatase activity ATP binding cytosol fructose metabolic process fructose 2,6-bisphosphate metabolic process metabolic process kinase activity phosphorylation dephosphorylation transferase activity hydrolase activity kinase binding animal organ regeneration response to insulin positive regulation of glucokinase activity response to glucagon response to starvation identical protein binding 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex carbohydrate phosphorylation response to glucocorticoid response to cAMP fructose-6-phosphate binding uc292rcm.1 uc292rcm.2 
ENSMUST00000112717.3 Serpinb3a ENSMUST00000112717.3 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A (from RefSeq NM_009126.3) ENSMUST00000112717.1 ENSMUST00000112717.2 G3X9V8 G3X9V8_MOUSE NM_009126 Serpinb3a uc007chg.1 uc007chg.2 uc007chg.3 uc007chg.4 Belongs to the serpin family. Ov-serpin subfamily. protease binding serine-type endopeptidase inhibitor activity extracellular space negative regulation of peptidase activity negative regulation of endopeptidase activity enzyme binding protection from natural killer cell mediated cytotoxicity uc007chg.1 uc007chg.2 uc007chg.3 uc007chg.4 
ENSMUST00000112720.8 Apex2 ENSMUST00000112720.8 Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (from UniProt A2AFM3) A2AFM3 A2AFM3_MOUSE AB072498 Apex2 ENSMUST00000112720.1 ENSMUST00000112720.2 ENSMUST00000112720.3 ENSMUST00000112720.4 ENSMUST00000112720.5 ENSMUST00000112720.6 ENSMUST00000112720.7 uc009uom.1 uc009uom.2 uc009uom.3 Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.2; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= Note=Probably binds two magnesium or manganese ions per subunit. ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Nucleus Cytoplasm Mitochondrion Belongs to the DNA repair enzymes AP/ExoA family. fibrillar center DNA binding nuclease activity endonuclease activity nucleus cytoplasm mitochondrion DNA repair cellular response to DNA damage stimulus zinc ion binding hydrolase activity lyase activity intracellular membrane-bounded organelle metal ion binding nucleic acid phosphodiester bond hydrolysis uc009uom.1 uc009uom.2 uc009uom.3 
ENSMUST00000112728.9 Gm10413 ENSMUST00000112728.9 predicted gene 10413 (from RefSeq NM_029288.3) ENSMUST00000112728.1 ENSMUST00000112728.2 ENSMUST00000112728.3 ENSMUST00000112728.4 ENSMUST00000112728.5 ENSMUST00000112728.6 ENSMUST00000112728.7 ENSMUST00000112728.8 Gm10413 Gm3012 L7N465 L7N465_MOUSE NM_029288 uc288qhm.1 uc288qhm.2 molecular_function cellular_component biological_process uc288qhm.1 uc288qhm.2 
ENSMUST00000112736.8 Vps4b ENSMUST00000112736.8 Endosome membrane ; Peripheral membrane protein Late endosome membrane ; Peripheral membrane protein Membrane ; Peripheral membrane protein (from UniProt Q3TN07) AK165594 ENSMUST00000112736.1 ENSMUST00000112736.2 ENSMUST00000112736.3 ENSMUST00000112736.4 ENSMUST00000112736.5 ENSMUST00000112736.6 ENSMUST00000112736.7 Q3TN07 Q3TN07_MOUSE Vps4b uc287kxl.1 uc287kxl.2 Endosome membrane ; Peripheral membrane protein Late endosome membrane ; Peripheral membrane protein Membrane ; Peripheral membrane protein Belongs to the AAA ATPase family. nucleotide binding spindle pole ATP binding nucleus cytoplasm endosome centrosome nucleus organization mitotic metaphase plate congression protein C-terminus binding endosome membrane regulation of centrosome duplication positive regulation of G2/M transition of mitotic cell cycle endosomal transport ATPase activity viral release from host cell endosome to lysosome transport via multivesicular body sorting pathway response to lipid viral budding via host ESCRT complex ATPase activity, coupled identical protein binding protein homodimerization activity ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway positive regulation of viral process regulation of viral process protein depolymerization negative regulation of cell death Flemming body ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway regulation of mitotic spindle assembly positive regulation of viral release from host cell negative regulation of exosomal secretion positive regulation of exosomal secretion positive regulation of centriole elongation positive regulation of viral life cycle uc287kxl.1 uc287kxl.2 
ENSMUST00000112740.2 Gm15091 ENSMUST00000112740.2 predicted gene 15091 (from RefSeq NM_001122735.1) B1AZM2 B1AZM2_MOUSE ENSMUST00000112740.1 Gm15091 NM_001122735 uc012hqk.1 uc012hqk.2 molecular_function cellular_component biological_process uc012hqk.1 uc012hqk.2 
ENSMUST00000112751.2 Bcl2 ENSMUST00000112751.2 B cell leukemia/lymphoma 2, transcript variant 1 (from RefSeq NM_009741.5) BCL2_MOUSE Bcl-2 ENSMUST00000112751.1 NM_009741 P10417 P10418 Q4VBF6 uc007cgw.1 uc007cgw.2 uc007cgw.3 uc007cgw.4 uc007cgw.5 This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and autophagy. Abnormal expression and chromosomal translocations of this gene are associated with cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl- X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By similarity). Also interacts with APAF1, BBC3, BCL2L1, BNIPL, MRPL41 and TP53BP2. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in an ATP-dependent manner. Interacts with RAF1 (the 'Ser-338' and 'Ser-339' phosphorylated form). Interacts (via the BH4 domain) with EGLN3; the interaction prevents the formation of the BAX-BCL2 complex and inhibits the anti-apoptotic activity of BCL2 (By similarity). Interacts with EI24. Interacts with G0S2; this interaction also prevents the formation of the anti-apoptotic BAX-BCL2 complex. Interacts with PPIF; the interaction is impaired by CsA (By similarity). Interacts with BOP (By similarity). Interacts with the SCF(FBXO10) complex (By similarity). Interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats) (By similarity). Interacts with GIMAP3/IAN4 and GIMAP4/IAN1 (PubMed:16509771). Also interacts with GIMAP5/IAN5 (PubMed:16509771, PubMed:21502331). Interacts with BCAP31 (By similarity). Interacts with IRF3 (By similarity). Interacts with BECN1; thereby inhibiting autophagy in non- starvation conditions (By similarity). Interacts with AMBRA1; thereby inhibiting autophagy (By similarity). P10417; Q07813: Bax; NbExp=2; IntAct=EBI-526314, EBI-700711; P10417; O54918-1: Bcl2l11; NbExp=2; IntAct=EBI-526314, EBI-526076; P10417; O88597: Becn1; NbExp=11; IntAct=EBI-526314, EBI-643716; P10417; Q99MI6: Gimap3; NbExp=4; IntAct=EBI-526314, EBI-15572304; P10417; Q8BWF2: Gimap5; NbExp=3; IntAct=EBI-526314, EBI-15572348; Mitochondrion outer membrane ; Single-pass membrane protein Nucleus membrane ; Single- pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=Alpha; IsoId=P10417-1; Sequence=Displayed; Name=Beta; IsoId=P10417-2; Sequence=VSP_000513; Expressed in a variety of tissues. The BH4 motif is required for anti-apoptotic activity and for interaction with RAF1 and EGLN3. BH1 and BH2 domains are required for the interaction with BAX and for anti-apoptotic activity. The loop between motifs BH4 and BH3 is required for the interaction with NLRP1. The BH3 motif is required for XIAP-mediated ubiquitination and subsequent induction of apoptosis. Phosphorylation/dephosphorylation on Ser-70 regulates anti- apoptotic activity (PubMed:9115213). Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle (PubMed:9115213). In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress- activated kinases (PubMed:9115213). Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-84, wich stimulates starvation-induced autophagy (By similarity). Dephosphorylated by protein phosphatase 2A (PP2A) (PubMed:9852076). Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity. Monoubiquitinated by PRKN, leading to an increase in its stability (By similarity). Ubiquitinated by SCF(FBXO10), leading to its degradation by the proteasome (By similarity). In response to intraperitoneal injection of muramyl dipeptide (MDP), knockout animals show lower serum IL1B levels than wild type. Mutant macrophages release 30% less IL1B than the wild- type cells. Belongs to the Bcl-2 family. protein polyubiquitination cell morphogenesis ossification ovarian follicle development metanephros development ureteric bud development branching involved in ureteric bud morphogenesis behavioral fear response leukocyte homeostasis B cell homeostasis kidney development release of cytochrome c from mitochondria regulation of cell-matrix adhesion protease binding lymphocyte homeostasis lymphoid progenitor cell differentiation B cell lineage commitment T cell lineage commitment immune system development response to ischemia renal system process protein binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane endoplasmic reticulum endoplasmic reticulum membrane cytosol protein dephosphorylation melanin metabolic process regulation of nitrogen utilization cellular calcium ion homeostasis apoptotic process cellular response to DNA damage stimulus response to oxidative stress actin filament organization axonogenesis cell aging transcription factor binding cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation male gonad development extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic mitochondrial changes response to toxic substance post-embryonic development animal organ morphogenesis response to iron ion response to UV-B response to gamma radiation regulation of gene expression regulation of autophagy negative regulation of autophagy negative regulation of calcium ion transport into cytosol regulation of glycoprotein biosynthetic process negative regulation of cardiac muscle cell apoptotic process mesenchymal cell development positive regulation of neuron maturation positive regulation of smooth muscle cell migration channel activity membrane integral component of membrane channel inhibitor activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation protein phosphatase binding cochlear nucleus development gland morphogenesis regulation of transmembrane transporter activity hemopoiesis B cell differentiation T cell differentiation negative regulation of ossification positive regulation of cell growth negative regulation of cell growth melanocyte differentiation negative regulation of cell migration positive regulation of B cell proliferation hair follicle morphogenesis axon regeneration ubiquitin protein ligase binding regulation of protein stability nuclear membrane mitochondrial membrane endoplasmic reticulum calcium ion homeostasis glomerulus development negative regulation of cellular pH reduction regulation of protein localization macromolecular complex negative regulation of myeloid cell apoptotic process T cell differentiation in thymus positive regulation of peptidyl-serine phosphorylation negative regulation of osteoblast proliferation response to cytokine response to nicotine organ growth regulation of growth positive regulation of multicellular organism growth B cell proliferation cellular response to glucose starvation response to drug response to hydrogen peroxide identical protein binding protein homodimerization activity regulation of apoptotic process T cell homeostasis negative regulation of apoptotic process regulation of programmed cell death positive regulation of catalytic activity myelin sheath CD8-positive, alpha-beta T cell lineage commitment pigmentation regulation of protein homodimerization activity regulation of protein heterodimerization activity negative regulation of neuron apoptotic process sequence-specific DNA binding ear development regulation of viral genome replication response to ethanol positive regulation of melanocyte differentiation negative regulation of mitotic cell cycle negative regulation of retinal cell programmed cell death regulation of mitochondrial membrane permeability pore complex protein heterodimerization activity focal adhesion assembly developmental pigmentation regulation of developmental pigmentation positive regulation of developmental pigmentation perinuclear region of cytoplasm spleen development thymus development response to steroid hormone digestive tract morphogenesis developmental growth oocyte development positive regulation of skeletal muscle fiber development pigment granule organization homeostasis of number of cells within a tissue regulation of catalytic activity B cell receptor signaling pathway response to glucocorticoid BH domain binding neuron apoptotic process BH3 domain binding defense response to virus protein phosphatase 2A binding regulation of cell cycle regulation of mitochondrial membrane potential regulation of calcium ion transport transmembrane transport intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress repressing transcription factor binding cellular response to organic substance cellular response to hypoxia reactive oxygen species metabolic process extrinsic apoptotic signaling pathway in absence of ligand cell-cell adhesion negative regulation of G1/S transition of mitotic cell cycle negative regulation of reactive oxygen species metabolic process negative regulation of anoikis negative regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway uc007cgw.1 uc007cgw.2 uc007cgw.3 uc007cgw.4 uc007cgw.5 
ENSMUST00000112754.8 Mbd5 ENSMUST00000112754.8 methyl-CpG binding domain protein 5, transcript variant 2 (from RefSeq NM_001290656.1) B1AYB6 ENSMUST00000112754.1 ENSMUST00000112754.2 ENSMUST00000112754.3 ENSMUST00000112754.4 ENSMUST00000112754.5 ENSMUST00000112754.6 ENSMUST00000112754.7 MBD5_MOUSE NM_001290656 uc289vzt.1 uc289vzt.2 Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro) (By similarity). Nucleus Chromosome Note=Associated with pericentric heterochromatin. Ubiquitous. Expressed in embryo at 7, 11, 15 and 17 dpc. Both MBD and PWWP domains are necessary for chromocentric localization. chromatin binding nucleus chromosome nervous system development chromocenter midbody regulation of multicellular organism growth glucose homeostasis regulation of behavior positive regulation of growth hormone receptor signaling pathway DNA binding uc289vzt.1 uc289vzt.2 
ENSMUST00000112755.5 Gm8334 ENSMUST00000112755.5 Gm8334 (from geneSymbol) ENSMUST00000112755.1 ENSMUST00000112755.2 ENSMUST00000112755.3 ENSMUST00000112755.4 uc292ran.1 uc292ran.2 uc292ran.3 uc292ran.4 uc292ran.1 uc292ran.2 uc292ran.3 uc292ran.4 
ENSMUST00000112758.10 Gm3383 ENSMUST00000112758.10 predicted gene 3383, transcript variant 2 (from RefSeq NM_001291094.1) A6NAS6 A6NAS6_MOUSE ENSMUST00000112758.1 ENSMUST00000112758.2 ENSMUST00000112758.3 ENSMUST00000112758.4 ENSMUST00000112758.5 ENSMUST00000112758.6 ENSMUST00000112758.7 ENSMUST00000112758.8 ENSMUST00000112758.9 Gm3194 Gm3383 NM_001291094 uc288qmy.1 uc288qmy.2 uc288qmy.1 uc288qmy.2 
ENSMUST00000112771.2 Dspp ENSMUST00000112771.2 dentin sialophosphoprotein (from RefSeq NM_010080.3) Dspp E9Q9Z9 E9Q9Z9_MOUSE ENSMUST00000112771.1 NM_010080 uc008ykd.1 uc008ykd.2 uc008ykd.3 uc008ykd.4 This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mice lacking the encoded protein exhibit hypomineralization defects in dentin, similar to human dentinogenesis imperfecta. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U67916.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01164131, SAMN01164132 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## uc008ykd.1 uc008ykd.2 uc008ykd.3 uc008ykd.4 
ENSMUST00000112776.4 Gm3173 ENSMUST00000112776.4 predicted gene 3173, transcript variant 5 (from RefSeq NM_001374160.1) E9Q9Z8 E9Q9Z8_MOUSE ENSMUST00000112776.1 ENSMUST00000112776.2 ENSMUST00000112776.3 Gm3173 NM_001374160 uc288qjv.1 uc288qjv.2 uc288qjv.1 uc288qjv.2 
ENSMUST00000112787.9 Gm3099 ENSMUST00000112787.9 RIKEN cDNA 4930555G01 gene (from RefSeq NM_175393.4) ENSMUST00000112787.1 ENSMUST00000112787.2 ENSMUST00000112787.3 ENSMUST00000112787.4 ENSMUST00000112787.5 ENSMUST00000112787.6 ENSMUST00000112787.7 ENSMUST00000112787.8 Gm3099 L7N255 L7N255_MOUSE NM_175393 uc288qis.1 uc288qis.2 molecular_function cellular_component biological_process uc288qis.1 uc288qis.2 
ENSMUST00000112788.4 Gm15114 ENSMUST00000112788.4 predicted gene 15114 (from RefSeq NM_001082966.1) B1B0X6 B1B0X6_MOUSE ENSMUST00000112788.1 ENSMUST00000112788.2 ENSMUST00000112788.3 Gm15114 NM_001082966 uc009unw.1 uc009unw.2 molecular_function cellular_component biological_process uc009unw.1 uc009unw.2 
ENSMUST00000112796.2 Gm15107 ENSMUST00000112796.2 predicted gene 15107 (from RefSeq NM_001081648.1) B1B0X0 B1B0X0_MOUSE ENSMUST00000112796.1 Gm15107 NM_001081648 uc009unp.1 uc009unp.2 molecular_function cellular_component biological_process uc009unp.1 uc009unp.2 
ENSMUST00000112797.12 D830030K20Rik ENSMUST00000112797.12 D830030K20Rik (from geneSymbol) AK085928 D830030K20Rik E9PYD0 E9PYQ5 E9PYQ5_MOUSE E9PYU2 E9Q3W9 E9Q8D4 ENSMUST00000112797.1 ENSMUST00000112797.10 ENSMUST00000112797.11 ENSMUST00000112797.2 ENSMUST00000112797.3 ENSMUST00000112797.4 ENSMUST00000112797.5 ENSMUST00000112797.6 ENSMUST00000112797.7 ENSMUST00000112797.8 ENSMUST00000112797.9 F6V4Q9 Gm3760 uc288qgy.1 uc288qgy.2 molecular_function cellular_component biological_process uc288qgy.1 uc288qgy.2 
ENSMUST00000112802.9 Gm3012 ENSMUST00000112802.9 predicted gene 3012 (from RefSeq NM_001378623.1) ENSMUST00000112802.1 ENSMUST00000112802.2 ENSMUST00000112802.3 ENSMUST00000112802.4 ENSMUST00000112802.5 ENSMUST00000112802.6 ENSMUST00000112802.7 ENSMUST00000112802.8 Gm10413 Gm3012 L7N465 L7N465_MOUSE NM_001378623 uc288qhv.1 uc288qhv.2 molecular_function cellular_component biological_process uc288qhv.1 uc288qhv.2 
ENSMUST00000112803.3 Hsd17b13 ENSMUST00000112803.3 hydroxysteroid (17-beta) dehydrogenase 13, transcript variant 1 (from RefSeq NM_001163486.1) A8Y5N6 DHB13_MOUSE ENSMUST00000112803.1 ENSMUST00000112803.2 NM_001163486 Q8CIU2 Q8VCR2 Scdr9 uc008yjx.1 uc008yjx.2 uc008yjx.3 uc008yjx.4 Plays a pivotal role in hepatic lipid metabolism. In vitro, it catalyzes the oxidation of a variety of lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4. Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence=; Reaction=all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH; Xref=Rhea:RHEA:21284, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.105; Evidence=; Reaction=all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:42080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Lipid droplet Endoplasmic reticulum Lipid droplet Note=Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VCR2-1; Sequence=Displayed; Name=2; IsoId=Q8VCR2-2; Sequence=VSP_015861; Expressed predominantly in the liver (at protein level). Belongs to the short-chain dehydrogenases/reductases (SDR) family. endoplasmic reticulum lipid particle steroid dehydrogenase activity oxidoreductase activity positive regulation of lipid biosynthetic process oxidation-reduction process uc008yjx.1 uc008yjx.2 uc008yjx.3 uc008yjx.4 
ENSMUST00000112804.3 Gm15080 ENSMUST00000112804.3 predicted gene 15080 (from RefSeq NM_001198988.1) A2BI02 A2BI02_MOUSE ENSMUST00000112804.1 ENSMUST00000112804.2 Gm15080 NM_001198988 uc009unm.1 uc009unm.2 molecular_function cellular_component biological_process uc009unm.1 uc009unm.2 
ENSMUST00000112810.8 Gtdc1 ENSMUST00000112810.8 glycosyltransferase-like domain containing 1, transcript variant 1 (from RefSeq NM_172662.3) A2AQR9 A2AQS2 A2AVU2 ENSMUST00000112810.1 ENSMUST00000112810.2 ENSMUST00000112810.3 ENSMUST00000112810.4 ENSMUST00000112810.5 ENSMUST00000112810.6 ENSMUST00000112810.7 GTDC1_MOUSE NM_172662 Q3TQ41 Q80US3 Q8BW56 Q8C1B8 uc008jpa.1 uc008jpa.2 uc008jpa.3 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BW56-1; Sequence=Displayed; Name=2; IsoId=Q8BW56-2; Sequence=VSP_029380; Name=3; IsoId=Q8BW56-3; Sequence=VSP_029381, VSP_029382; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. Sequence=AAH52069.1; Type=Erroneous initiation; Evidence=; Sequence=BAC35713.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc008jpa.1 uc008jpa.2 uc008jpa.3 
ENSMUST00000112814.8 Gm15128 ENSMUST00000112814.8 Gm15128 (from geneSymbol) A2ADW8 A2ADW8_MOUSE BC109131 ENSMUST00000112814.1 ENSMUST00000112814.2 ENSMUST00000112814.3 ENSMUST00000112814.4 ENSMUST00000112814.5 ENSMUST00000112814.6 ENSMUST00000112814.7 Gm15128 uc292raa.1 uc292raa.2 molecular_function cellular_component biological_process uc292raa.1 uc292raa.2 
ENSMUST00000112819.9 Lrch2 ENSMUST00000112819.9 leucine-rich repeats and calponin homology (CH) domain containing 2, transcript variant 5 (from RefSeq NM_001403579.1) A2AMN8 ENSMUST00000112819.1 ENSMUST00000112819.2 ENSMUST00000112819.3 ENSMUST00000112819.4 ENSMUST00000112819.5 ENSMUST00000112819.6 ENSMUST00000112819.7 ENSMUST00000112819.8 Kiaa1495 LRCH2_MOUSE NM_001403579 Q3UMG5 Q7TNP9 Q80TC9 uc292qzt.1 uc292qzt.2 May play a role in the organization of the cytoskeleton. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UMG5-1; Sequence=Displayed; Name=2; IsoId=Q3UMG5-2; Sequence=VSP_021041; Name=3; IsoId=Q3UMG5-3; Sequence=VSP_021042; Sequence=BAC65798.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=CAM22136.1; Type=Erroneous initiation; Evidence=; Sequence=CAM24878.1; Type=Erroneous initiation; Evidence=; molecular_function uc292qzt.1 uc292qzt.2 
ENSMUST00000112830.3 Ankrd26 ENSMUST00000112830.3 ankyrin repeat domain 26 (from RefSeq NM_001081112.2) Ankrd26 D3Z482 D3Z482_MOUSE ENSMUST00000112830.1 ENSMUST00000112830.2 NM_001081112 uc009dlr.1 uc009dlr.2 uc009dlr.3 uc009dlr.1 uc009dlr.2 uc009dlr.3 
ENSMUST00000112832.8 Rorb ENSMUST00000112832.8 RAR-related orphan receptor beta, transcript variant 1 (from RefSeq NM_001043354.2) ENSMUST00000112832.1 ENSMUST00000112832.2 ENSMUST00000112832.3 ENSMUST00000112832.4 ENSMUST00000112832.5 ENSMUST00000112832.6 ENSMUST00000112832.7 NM_001043354 Nr1f2 Q0PQZ2 Q0PQZ3 Q1MVR9 Q8R1B8 RORB_MOUSE uc008gye.1 uc008gye.2 uc008gye.3 uc008gye.4 The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity. Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4. Monomer. Interacts with CRX. Nucleus Nucleus, nucleoplasm Event=Alternative promoter usage; Named isoforms=2; Name=2; IsoId=Q8R1B8-2; Sequence=Displayed; Name=1; IsoId=Q8R1B8-1; Sequence=VSP_022576; Expressed in inner and outer neuroblastic layer as well as in the ganglion cell layer of the developing retina. Expressed in bone marrow osteoprogenitor cells. Expressed in the lateral cortical plate at 18.5 dpc and only very weakly expressed by cortical neurons at 15.5 dpc. Expression progressively increases in layer IV neurons of the prospective somatosensory, visual and auditory cortices. At much lower levels, also expressed by scattered neurons in layer V in these areas. By P4, expression is striking in the whisker barrel cortex of the somatosensory cortex. During retinal development, isoform 1 is broadly expressed in between 13.5 dpc and P5 then declines and is maintained at lower levels into adulthood. At 15.5 dpc, is expressed in the immature cochlea, brainstem, spinal cord and cerebral cortex. Isoform 2 is first detected at low levels at late embryonic stages (18.5 dpc), the expression highly increases during the first postnatal week and is maintained during the adulthood. Induced by aging in bone marrow. AF-2 (activation function-2) motif is required for recruiting coregulators containing the LXXLL motif, such as NCOA1, and control the transactivational activity. Mice are blind, show juvenile ataxia, duck gait, hind paw clasping reflex as well as delayed onset of male fertility. They suffer a degeneration of the retina during postnatal development with severe defects in photoreceptor cell morphology. Mice display reduced anxiety and learned helplessness-related behaviors. They also show a significant increase of the circadian period. Knockouts for isoform 1 display duck gait and lack amacrine and horizontal cells with an excess of ganglion cells in the retina (PubMed:23652001). Belongs to the nuclear hormone receptor family. NR1 subfamily. Sequence=AAH24842.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=AAH58269.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated G-protein coupled receptor signaling pathway multicellular organism development visual perception transcription factor binding zinc ion binding melatonin receptor activity intracellular receptor signaling pathway amacrine cell differentiation eye photoreceptor cell development regulation of circadian rhythm steroid hormone mediated signaling pathway sequence-specific DNA binding negative regulation of osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinal rod cell development retinal cone cell development metal ion binding rhythmic process response to stimulus retina development in camera-type eye cellular response to retinoic acid uc008gye.1 uc008gye.2 uc008gye.3 uc008gye.4 
ENSMUST00000112836.9 Amot ENSMUST00000112836.9 angiomotin, transcript variant 1 (from RefSeq NM_153319.4) A2AMJ9 A2AMK0 AMOT_MOUSE ENSMUST00000112836.1 ENSMUST00000112836.2 ENSMUST00000112836.3 ENSMUST00000112836.4 ENSMUST00000112836.5 ENSMUST00000112836.6 ENSMUST00000112836.7 ENSMUST00000112836.8 Kiaa1071 NM_153319 Q6PFB8 Q6ZPZ1 Q8VHG2 uc009una.1 uc009una.2 uc009una.3 uc009una.4 Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions (By similarity). Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3. Interacts with MAGI1 and angiostatin (By similarity). Cell junction, tight junction Note=Localized on the cell surface. May act as a transmembrane protein (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VHG2-1; Sequence=Displayed; Name=2; IsoId=Q8VHG2-2; Sequence=VSP_027108, VSP_027109; Expressed in brain, skeletal muscle and placenta. The angiostatin binding domain (850-1047) allows the binding to angiostatin. The coiled coil domain interacts directly with the BAR domain of ARHGAP17. Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation. 'Motus' means 'motility' in Latin. Belongs to the angiomotin family. Sequence=AAH57638.1; Type=Erroneous initiation; Evidence=; Sequence=AAL73436.1; Type=Erroneous initiation; Evidence=; Sequence=CAM22158.1; Type=Erroneous initiation; Evidence=; Sequence=CAM22159.1; Type=Erroneous initiation; Evidence=; angiogenesis vasculogenesis in utero embryonic development gastrulation with mouth forming second stress fiber ruffle establishment of cell polarity involved in ameboidal cell migration protein binding nucleus cytoplasm actin filament bicellular tight junction chemotaxis COP9 signalosome external side of plasma membrane cell surface integral component of membrane negative regulation of angiogenesis lamellipodium actin cytoskeleton organization cell junction endocytic vesicle regulation of cell migration cytoplasmic vesicle negative regulation of GTPase activity cellular protein localization hippo signaling signaling receptor activity positive regulation of embryonic development cell migration involved in gastrulation negative regulation of vascular permeability angiostatin binding blood vessel endothelial cell migration positive regulation of blood vessel endothelial cell migration blood vessel morphogenesis regulation of small GTPase mediated signal transduction uc009una.1 uc009una.2 uc009una.3 uc009una.4 
ENSMUST00000112843.2 Rtl4 ENSMUST00000112843.2 retrotransposon Gag like 4 (from RefSeq NM_001033795.4) A2AMQ0 B2RSQ2 ENSMUST00000112843.1 Mar4 Mart4 NM_001033795 Q3URY0 Q3UVU7 RTL4_MOUSE Rtl4 Sirh11 Zcchc16 uc009umy.1 uc009umy.2 uc009umy.3 uc009umy.4 Involved in cognitive function in the brain, possibly via the noradrenergic system. In adults, expressed in brain, eye, kidney, ovary and testis (PubMed:26402067, PubMed:15716091). Weakly expressed in thymus, heart and muscle (PubMed:15716091). Expressed at 12.5 dpc in almost all tissues tested. Expressed at 14.5 dpc in brain, eye and liver. Weakly expressed in lung, heart and kidney. Mutants are viable and don't show growth retardation in the pre- and postnatal periods in either female or male mice (PubMed:26402067). Animals are fertile, even in the case of mating between mutants. They exhibit abnormal behaviors related to cognition, including attention, impulsivity, and working memory (PubMed:26402067). Animals show a reduced recovery rate of noradrenaline in the prefrontal cortex region (PubMed:26402067). RTL4 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. Sequence=BAE23172.1; Type=Frameshift; Evidence=; molecular_function nucleic acid binding cellular_component zinc ion binding norepinephrine metabolic process metal ion binding cognition uc009umy.1 uc009umy.2 uc009umy.3 uc009umy.4 
ENSMUST00000112844.10 Gin1 ENSMUST00000112844.10 gypsy retrotransposon integrase 1, transcript variant 1 (from RefSeq NM_026250.3) ENSMUST00000112844.1 ENSMUST00000112844.2 ENSMUST00000112844.3 ENSMUST00000112844.4 ENSMUST00000112844.5 ENSMUST00000112844.6 ENSMUST00000112844.7 ENSMUST00000112844.8 ENSMUST00000112844.9 GIN1_MOUSE NM_026250 Q3TEY8 Q3V2V3 Q8C3X6 Q8K259 Q9CXB6 Q9D5K2 Zh2c2 uc007cfn.1 uc007cfn.2 uc007cfn.3 uc007cfn.4 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K259-1; Sequence=Displayed; Name=2; IsoId=Q8K259-2; Sequence=VSP_033440; Name=3; IsoId=Q8K259-3; Sequence=VSP_033441, VSP_033442; nucleic acid binding DNA integration uc007cfn.1 uc007cfn.2 uc007cfn.3 uc007cfn.4 
ENSMUST00000112845.8 Ppip5k2 ENSMUST00000112845.8 diphosphoinositol pentakisphosphate kinase 2, transcript variant 15 (from RefSeq NM_001405471.1) E9Q9J4 E9Q9J4_MOUSE ENSMUST00000112845.1 ENSMUST00000112845.2 ENSMUST00000112845.3 ENSMUST00000112845.4 ENSMUST00000112845.5 ENSMUST00000112845.6 ENSMUST00000112845.7 NM_001405471 Ppip5k2 uc287ksl.1 uc287ksl.2 Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2- InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6). Reaction=1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo- inositol 2,3,4,5,6-pentakisphosphate + ADP; Xref=Rhea:RHEA:37459, ChEBI:CHEBI:30616, ChEBI:CHEBI:58130, ChEBI:CHEBI:74946, ChEBI:CHEBI:456216; EC=2.7.4.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37460; Evidence=; Reaction=5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP; Xref=Rhea:RHEA:10276, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58628, ChEBI:CHEBI:77983, ChEBI:CHEBI:456216; EC=2.7.4.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10277; Evidence=; Cytoplasm, cytosol Belongs to the histidine acid phosphatase family. VIP1 subfamily. nucleotide binding inositol heptakisphosphate kinase activity inositol hexakisphosphate 5-kinase activity ATP binding cytoplasm cytosol kinase activity phosphorylation transferase activity diphosphoinositol-pentakisphosphate kinase activity inositol hexakisphosphate 1-kinase activity inositol hexakisphosphate 3-kinase activity uc287ksl.1 uc287ksl.2 
ENSMUST00000112856.3 Dcx ENSMUST00000112856.3 doublecortin, transcript variant 4 (from RefSeq NM_010025.2) Dcx ENSMUST00000112856.1 ENSMUST00000112856.2 NM_010025 Q9CXL6 Q9CXL6_MOUSE uc009umm.1 uc009umm.2 uc009umm.3 This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase. Studies in knockout mice lacking this gene and the LIS1 gene suggest that the molecular interaction of these two genes is important in both in neuronal migration and neurogenesis, and there is a cortical role of this gene in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. Multiple transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]. intracellular signal transduction uc009umm.1 uc009umm.2 uc009umm.3 
ENSMUST00000112862.7 Arpc5l ENSMUST00000112862.7 actin related protein 2/3 complex, subunit 5-like, transcript variant 1 (from RefSeq NM_028809.2) ARP5L_MOUSE ENSMUST00000112862.1 ENSMUST00000112862.2 ENSMUST00000112862.3 ENSMUST00000112862.4 ENSMUST00000112862.5 ENSMUST00000112862.6 NM_028809 Q9D898 uc008joa.1 uc008joa.2 uc008joa.3 May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May be a component of the Arp2/3 complex in which it may replace ARPC5. Cytoplasm, cytoskeleton Belongs to the ARPC5 family. actin binding cytoplasm cytoskeleton Arp2/3 protein complex actin cytoskeleton cell migration regulation of actin filament polymerization Arp2/3 complex-mediated actin nucleation synapse actin filament binding glutamatergic synapse uc008joa.1 uc008joa.2 uc008joa.3 
ENSMUST00000112868.8 Pak3 ENSMUST00000112868.8 Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity (PubMed:25851601). Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (PubMed:15800193). (from UniProt Q61036) AK031853 ENSMUST00000112868.1 ENSMUST00000112868.2 ENSMUST00000112868.3 ENSMUST00000112868.4 ENSMUST00000112868.5 ENSMUST00000112868.6 ENSMUST00000112868.7 O88645 PAK3_MOUSE Pak-3 Pakb Q61036 Q8K1R5 Q8K1R6 Stk4 uc292qxd.1 uc292qxd.2 Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity (PubMed:25851601). Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (PubMed:15800193). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-436 and allows the kinase domain to adopt an active structure (By similarity). Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. Interacts with the C- terminal of APP. Interacts with ARHGEF6 and ARHGEF7 (By similarity). Interacts with GIT1 and GIT2 (By similarity). Q61036; P60953: CDC42; Xeno; NbExp=3; IntAct=EBI-457317, EBI-81752; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61036-1; Sequence=Displayed; Name=2; IsoId=Q61036-2; Sequence=VSP_010243; Autophosphorylated when activated by CDC42/p21. Neddylated. Mice show significant abnormalities in synaptic plasticity as well as deficiencies in learning and memory. Pak1 and Pak3 double knockout mice display reduced brains characterized by simplified neuronal dendrites/axons and reduced synapse density. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. MAPK cascade nucleotide binding activation of MAPK activity catalytic activity protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein binding ATP binding cytoplasm endosome cytosol protein phosphorylation multicellular organism development axonogenesis metabolic process positive regulation of fibroblast migration regulation of neuron projection development postsynaptic density kinase activity phosphorylation dendrite development transferase activity Rho GTPase binding SH3 domain binding signal transduction by protein phosphorylation regulation of actin filament polymerization activation of protein kinase activity regulation of actin cytoskeleton organization positive regulation of neuron apoptotic process metal ion binding regulation of axonogenesis GTPase binding dendritic spine development dendritic spine morphogenesis positive regulation of dendritic spine morphogenesis cellular response to organic cyclic compound glutamatergic synapse positive regulation of DNA biosynthetic process uc292qxd.1 uc292qxd.2 
ENSMUST00000112871.8 Cxcl12 ENSMUST00000112871.8 C-X-C motif chemokine ligand 12, transcript variant 2 (from RefSeq NM_013655.4) ENSMUST00000112871.1 ENSMUST00000112871.2 ENSMUST00000112871.3 ENSMUST00000112871.4 ENSMUST00000112871.5 ENSMUST00000112871.6 ENSMUST00000112871.7 NM_013655 P40224 Q4FJL5 Q543V6 SDF1_MOUSE Sdf1 uc009dku.1 uc009dku.2 uc009dku.3 uc009dku.4 This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]. Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (By similarity). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (PubMed:8134392). Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N-terminus of ACKR3. Interacts with integrin subunit ITGB3 (via the allosteric site (site 2)). Interacts with TNFAIP6 (via Link domain). Secreted. Event=Alternative splicing; Named isoforms=2; Name=Beta; IsoId=P40224-2; Sequence=Displayed; Name=Alpha; IsoId=P40224-1; Sequence=VSP_037607; Highest expression levels detected in kidney, liver, spleen and muscle. Isoform Alpha is expressed ubiquitously but at varying levels, while isoform Beta displays tissue-specific expression, with expression detected in kidney, liver, heart, spleen and muscle but not in lung, colon, brain, skin and stomach. Down-regulated by 12-O-tetradecanoylphorbol 13-acetate (TPA), with 5-fold decrease in expression levels at 1 hour after TPA treatment, 12-fold decrease at 4 hours, undetectable levels after 8 hours and low-level expression returning at 24 hours after treatment. Down-regulated by serum stimulation, with expression levels reaching their minimum at 4 hours after stimulation and returning back to normal levels at 16 hours after stimulation. Half of the embryos die by 18.5 dpc, and neonates die within an hour. Mutants display defective B-lymphopoiesis, defective myelopoiesis in the bone marrow but not in the liver, and defective formation of the heart ventricular septum. Belongs to the intercrine alpha (chemokine CxC) family. branching involved in blood vessel morphogenesis ameboidal-type cell migration neuron migration positive regulation of endothelial cell proliferation cytokine activity integrin binding extracellular region extracellular space nucleus cytoplasm plasma membrane chemotaxis defense response immune response germ cell development brain development chemokine activity motor neuron axon guidance growth factor activity positive regulation of cell proliferation adult locomotory behavior germ cell migration external side of plasma membrane T cell chemotaxis telencephalon cell migration regulation of cell migration positive regulation of cell migration animal organ regeneration killing of cells of other organism positive regulation of dopamine secretion integrin activation chemokine (C-X-C motif) ligand 12 signaling pathway T cell proliferation chemokine receptor binding CXCR chemokine receptor binding positive regulation of neuron differentiation positive regulation of cell adhesion positive regulation of axon extension involved in axon guidance induction of positive chemotaxis detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain regulation of calcium ion transport cell chemotaxis chemokine-mediated signaling pathway dopaminergic neuron differentiation positive regulation of monocyte chemotaxis positive regulation of calcium ion import cell-cell adhesion positive regulation of myoblast fusion negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of leukocyte tethering or rolling cellular response to chemokine positive regulation of T cell migration negative regulation of dendritic cell apoptotic process uc009dku.1 uc009dku.2 uc009dku.3 uc009dku.4 
ENSMUST00000112872.2 Wdr38 ENSMUST00000112872.2 WD repeat domain 38 (from RefSeq NM_029687.4) ENSMUST00000112872.1 NM_029687 Q9D994 WDR38_MOUSE uc008jnx.1 uc008jnx.2 uc008jnx.3 uc008jnx.4 hematopoietic progenitor cell differentiation molecular_function cellular_component uc008jnx.1 uc008jnx.2 uc008jnx.3 uc008jnx.4 
ENSMUST00000112878.9 Chrdl1 ENSMUST00000112878.9 chordin-like 1, transcript variant 3 (from RefSeq NM_001358592.1) CRDL1_MOUSE ENSMUST00000112878.1 ENSMUST00000112878.2 ENSMUST00000112878.3 ENSMUST00000112878.4 ENSMUST00000112878.5 ENSMUST00000112878.6 ENSMUST00000112878.7 ENSMUST00000112878.8 NM_001358592 Ng1 Nrln1 Q920C1 Q924K0 Q9EPZ9 uc009ume.1 uc009ume.2 uc009ume.3 uc009ume.4 Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation (By similarity). Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the inducing activity of BMP2. Plays a role during anterior segment eye development (By similarity). Secreted Event=Alternative splicing; Named isoforms=2; Name=Alpha; IsoId=Q920C1-1; Sequence=Displayed; Name=Beta; IsoId=Q920C1-2; Sequence=VSP_001076, VSP_001077; Expressed in heart, brain, lung, liver, kidney and testis. Expression starts in the neural plate at mid- gastrulation. Later on its expression becomes restricted to discrete regions of the central nervous system and to derivatives of the neural crest cells. Expressed as well in the primordial cells of the skeleton in mice embryos at 13.5 dpc. May be glycosylated. ossification eye development cell fate determination extracellular region multicellular organism development nervous system development cell differentiation neuron differentiation negative regulation of BMP signaling pathway compound eye development uc009ume.1 uc009ume.2 uc009ume.3 uc009ume.4 
ENSMUST00000112887.8 Gpat3 ENSMUST00000112887.8 Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Protects cells against lipotoxicity (By similarity). (from UniProt Q8C0N2) A6H5X0 AK138410 Agpat9 ENSMUST00000112887.1 ENSMUST00000112887.2 ENSMUST00000112887.3 ENSMUST00000112887.4 ENSMUST00000112887.5 ENSMUST00000112887.6 ENSMUST00000112887.7 GPAT3_MOUSE Gpat3 Q8C0N2 uc008yii.1 uc008yii.2 uc008yii.3 Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Protects cells against lipotoxicity (By similarity). Reaction=an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3- phosphate + CoA; Xref=Rhea:RHEA:15325, ChEBI:CHEBI:57287, ChEBI:CHEBI:57597, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342; EC=2.3.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15326; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19710; Evidence=; Reaction=dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn- glycerol 3-phosphate + CoA; Xref=Rhea:RHEA:35727, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:57597, ChEBI:CHEBI:72682; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35728; Evidence=; Reaction=hexadecanoyl-CoA + sn-glycerol 3-phosphate = 1-hexadecanoyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:35723, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57518, ChEBI:CHEBI:57597; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35724; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z- octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37199, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57597, ChEBI:CHEBI:74544; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37200; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1- (9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37203, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:57597, ChEBI:CHEBI:74547; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37204; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3- phosphate = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3- phosphate + CoA; Xref=Rhea:RHEA:37187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72683, ChEBI:CHEBI:74586; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37188; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:33187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57518, ChEBI:CHEBI:64839; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33188; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74544, ChEBI:CHEBI:74546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37132; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn- glycero-3-phosphate = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)- octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37179, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74581, ChEBI:CHEBI:74582; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37180; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn- glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)- octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37139, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74549, ChEBI:CHEBI:74550; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37140; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37171, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:74544, ChEBI:CHEBI:74579; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37172; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37143, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74544, ChEBI:CHEBI:74551; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37144; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37147, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:74544, ChEBI:CHEBI:74552; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37148; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero- 3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn- glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37159, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74544, ChEBI:CHEBI:74563; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37160; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn- glycero-3-phosphate = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)- octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37455, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74938, ChEBI:CHEBI:74941; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37456; Evidence=; Glycerolipid metabolism; triacylglycerol biosynthesis. Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 1/3. Endoplasmic reticulum membrane ; Multi-pass membrane protein Most abundant in epididymal fat, followed by small intestine, brown adipose tissue, kidney, heart and colon. During adipocyte differentiation. The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. 1-acylglycerol-3-phosphate O-acyltransferase activity glycerol-3-phosphate O-acyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process phospholipid biosynthetic process membrane integral component of membrane CDP-diacylglycerol biosynthetic process transferase activity transferase activity, transferring acyl groups triglyceride biosynthetic process regulation of TOR signaling uc008yii.1 uc008yii.2 uc008yii.3 
ENSMUST00000112925.8 Ift122 ENSMUST00000112925.8 intraflagellar transport 122, transcript variant 2 (from RefSeq NM_001167763.1) ENSMUST00000112925.1 ENSMUST00000112925.2 ENSMUST00000112925.3 ENSMUST00000112925.4 ENSMUST00000112925.5 ENSMUST00000112925.6 ENSMUST00000112925.7 IF122_MOUSE Ift122 NM_001167763 Q6KAU2 Q6NWV3 Q8C8U5 Q8CD77 Wdr10 uc009dji.1 uc009dji.2 uc009dji.3 uc009dji.4 As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking (By similarity). Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (PubMed:19000668, PubMed:21209331). Component of the IFT complex A (IFT-A) complex. IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B. Interacts with IFT43:WDR35; the interaction connects the 2 IFT-A subcomplexes. Interacts with IFTAP; the interaction associates IFTAP with IFT-A complex. Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Note=Localizes to photoreceptor connecting cilia. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NWV3-1; Sequence=Displayed; Name=2; IsoId=Q6NWV3-2; Sequence=VSP_039810; Expression at least from 7.5 dpc onwards throughout embryonic development with lower levels at 7.5 dpc and 9.5 dpc. Ubiquitously expressed at 11.5 dpc. Forms the trimeric core subcomplex IFT122:IFT140:WDR19 via the C-terminal region, whereas it interacts with IFT43:WDR35 via the N- terminal region containing the WD repeats. Embryonic lethal (manifesting between 11.5 dpc and 13.5 dpc). Multiple developmental defects (exencephaly, situs viscerum inversus, delay in turning, hemorrhage and defects in limb development). In the node, primary cilia are absent or malformed in homozygous mutant and heterozygous embryos, respectively. The Shh signaling pathway is impaired in both neural tube patterning (expansion of motoneurons and rostro-caudal level-dependent contraction or expansion of the dorso-lateral interneurons) and limb patterning (ectrosyndactyly). The proteolytic processing of Gli3 is altered. Defects in Ift122 are the cause of the sister of open brain (sopb) phenotype, a mutant that induces embryonic lethality and generates primary cilia with features of defective retrograde intraflagellar transport. Sequence=BAD21365.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; neural tube closure molecular_function nucleoplasm cytoplasm cytosol cytoskeleton cilium signal transduction downstream of smoothened multicellular organism development dorsal/ventral pattern formation embryonic body morphogenesis negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning cell projection organization intraciliary transport particle A photoreceptor connecting cilium embryonic heart tube development embryonic forelimb morphogenesis intraciliary anterograde transport intraciliary retrograde transport ciliary basal body intraciliary transport embryonic digit morphogenesis cell projection negative regulation of smoothened signaling pathway camera-type eye morphogenesis negative regulation of epithelial cell proliferation limb development cilium assembly ciliary receptor clustering involved in smoothened signaling pathway smoothened signaling pathway involved in dorsal/ventral neural tube patterning embryonic heart tube left/right pattern formation protein localization to cilium establishment of protein localization to organelle ciliary base non-motile cilium non-motile cilium assembly uc009dji.1 uc009dji.2 uc009dji.3 uc009dji.4 
ENSMUST00000112931.8 Col4a5 ENSMUST00000112931.8 collagen, type IV, alpha 5, transcript variant 3 (from RefSeq NM_001411947.1) Col4a5 ENSMUST00000112931.1 ENSMUST00000112931.2 ENSMUST00000112931.3 ENSMUST00000112931.4 ENSMUST00000112931.5 ENSMUST00000112931.6 ENSMUST00000112931.7 NM_001411947 Q63ZW6 Q63ZW6_MOUSE uc057mcg.1 uc057mcg.2 uc057mcg.3 Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Membrane Secreted, extracellular space, extracellular matrix, basement membrane extracellular matrix structural constituent collagen trimer collagen type IV trimer basement membrane extracellular space neuromuscular junction development extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix neuromuscular junction collagen-activated tyrosine kinase receptor signaling pathway uc057mcg.1 uc057mcg.2 uc057mcg.3 
ENSMUST00000112932.2 Zbtb6 ENSMUST00000112932.2 May be involved in transcriptional regulation. (from UniProt Q8K088) A2AWA4 AK053443 ENSMUST00000112932.1 Q8BLM4 Q8K088 ZBTB6_MOUSE Zfp482 Znf482 uc008jmt.1 uc008jmt.2 uc008jmt.3 uc008jmt.4 May be involved in transcriptional regulation. Nucleus negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus mitochondrion metal ion binding uc008jmt.1 uc008jmt.2 uc008jmt.3 uc008jmt.4 
ENSMUST00000112933.2 Cntf ENSMUST00000112933.2 ciliary neurotrophic factor (from RefSeq NM_170786.2) Cntf ENSMUST00000112933.1 NM_170786 Q544D1 Q544D1_MOUSE uc008gun.1 uc008gun.2 uc008gun.3 The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes, and it may be involved in reducing tissue destruction during inflammatory attacks. A read-through transcript variant composed of Zfp91 and Cntf sequences has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. [provided by RefSeq, Aug 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027539.1, SRR1660819.15948.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. Belongs to the CNTF family. ciliary neurotrophic factor receptor binding interleukin-6 receptor binding growth factor activity positive regulation of gene expression positive regulation of tyrosine phosphorylation of STAT protein negative regulation of neuron apoptotic process macromolecular complex binding ciliary neurotrophic factor-mediated signaling pathway uc008gun.1 uc008gun.2 uc008gun.3 
ENSMUST00000112935.8 Nmnat3 ENSMUST00000112935.8 nicotinamide nucleotide adenylyltransferase 3, transcript variant 1 (from RefSeq NM_144533.3) ENSMUST00000112935.1 ENSMUST00000112935.2 ENSMUST00000112935.3 ENSMUST00000112935.4 ENSMUST00000112935.5 ENSMUST00000112935.6 ENSMUST00000112935.7 NMNA3_MOUSE NM_144533 Nmnat3 Q58E37 Q99JR6 uc009rdh.1 uc009rdh.2 uc009rdh.3 Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Protects against axonal degeneration following injury. Reaction=ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+); Xref=Rhea:RHEA:21360, ChEBI:CHEBI:14649, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57540; EC=2.7.7.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21361; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21362; Evidence=; Reaction=ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate; Xref=Rhea:RHEA:22860, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57502, ChEBI:CHEBI:58437; EC=2.7.7.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22861; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22862; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Divalent metal cations. Mg(2+) confers the highest activity. ; Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')- tetraphosphate (Nap4AD) (By similarity). Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. Homotetramer. Mitochondrion Expressed throughout development and in adulthood. Belongs to the eukaryotic NMN adenylyltransferase family. nucleotide binding nicotinamide-nucleotide adenylyltransferase activity catalytic activity nicotinate-nucleotide adenylyltransferase activity ATP binding nucleus mitochondrion biosynthetic process NAD biosynthetic process response to wounding transferase activity nucleotidyltransferase activity pyridine nucleotide biosynthetic process axon response to tumor necrosis factor neuronal cell body uc009rdh.1 uc009rdh.2 uc009rdh.3 
ENSMUST00000112936.4 Rc3h2 ENSMUST00000112936.4 ring finger and CCCH-type zinc finger domains 2, transcript variant 1 (from RefSeq NM_001100591.1) A2AVP5 ENSMUST00000112936.1 ENSMUST00000112936.2 ENSMUST00000112936.3 Mnab NM_001100591 P0C090 RC3H2_MOUSE uc289vrc.1 uc289vrc.2 Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (PubMed:23663784). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (PubMed:23583643, PubMed:23583642). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (PubMed:25282160). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains. Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains. Involved in the ubiquitination of MAP3K5 (By similarity). Able to interact with double-stranded RNA (dsRNA). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Binding to dsRNA, but not CDE RNA, crosstalks with the E3 ubiquitin ligase activity and may inhibit ubiquitination. Protein modification; protein ubiquitination. Interacts with EDC4 (PubMed:23583643). Interacts with CCR4-NOT deadenylase complex (PubMed:23663784). Interacts with MAP3K5; the interaction is probably stimulus-dependent (By similarity). Cytoplasm, P-body Note=During stress, such as that induced by arsenite, localizes to cytosolic stress granules. Localization to stress granules, but not to P-bodies, depends upon the RING-type zinc finger. Highest levels in lymph node and thymus and slightly lesser amounts in brain, lung, and spleen (at protein level). Very weak expression in heart, muscle, and kidney (at protein level). Expressed in CD4(+) helper T-cells (at protein level). The RING-type zinc finger is required for proper localization to stress granules, but not to P-bodies. The ROQ region is required for CDE RNA-binding. Has 2 separate RNA-binding sites, one for CDE RNA and the other for dsRNA (PubMed:23663784). It may also be involved in localization to stress granules (By similarity). HEPN (higher eukaryotes and prokaryotes nucleotide-binding) are observed in both N- and C-terminal sides of ROQ domain with 3D structure even if they are poredcted on the basis of sequence. Proteolytically cleaved by MALT1 in activated CD4(+) T cells; cleavage at Arg-509 is critical for promoting RC3H1 degradation in response to T-cell receptor (TCR) stimulation, and hence is necessary for prolonging the stability of a set of mRNAs controlling Th17 cell differentiation. Mutant animals are born at Mendelian ratio, but very few reach adulthood, a large proportion die within the first days after birth. Lethality can be rescued by changing the genetic background from C57BL/6 to outbred NMRI, on which mutant animals appear healthy and fertile, although smaller. Immune cell homeostasis is normal (PubMed:23583643). However, Mice lacking both Rc3h1 and Rc3h2 genes in CD4(+) T-cells develop lymphadenopathy and splenomegaly with increased spleen weight and cellularity, already at young age. They show a prominent lung pathology with a progressive reduction in the alveolar space concomitant with inflammation. They show an average survival of 130 days. CD4(+) T-cells of these mutants show a pronounced bias toward Th17 differentiation (PubMed:23583643, PubMed:25282160). protein polyubiquitination P-body B cell homeostasis DNA binding RNA binding double-stranded RNA binding mRNA binding ubiquitin-protein transferase activity protein binding cytoplasm post-embryonic development cell surface regulation of gene expression posttranscriptional regulation of gene expression membrane protein ubiquitination transferase activity multicellular organism growth RNA stem-loop binding T cell proliferation T cell homeostasis intracellular membrane-bounded organelle metal ion binding lung alveolus development lymph node development spleen development T cell receptor signaling pathway limb development T follicular helper cell differentiation positive regulation of NIK/NF-kappaB signaling negative regulation of T-helper 17 cell differentiation regulation of miRNA metabolic process uc289vrc.1 uc289vrc.2 
ENSMUST00000112952.4 Or4d10c ENSMUST00000112952.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG74) A0A140LI01 BC058600 ENSMUST00000112952.1 ENSMUST00000112952.2 ENSMUST00000112952.3 Olfr1426 Or4d10c Q8VG74 Q8VG74_MOUSE uc008gto.1 uc008gto.2 uc008gto.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gto.1 uc008gto.2 uc008gto.3 
ENSMUST00000112957.2 Mkrn2os ENSMUST00000112957.2 makorin, ring finger protein 2, opposite strand (from RefSeq NM_001101431.1) D3Z393 D3Z393_MOUSE ENSMUST00000112957.1 Mkrn2os NM_001101431 uc012eqk.1 uc012eqk.2 uc012eqk.3 molecular_function cellular_component biological_process uc012eqk.1 uc012eqk.2 uc012eqk.3 
ENSMUST00000112960.8 Lhx6 ENSMUST00000112960.8 LIM homeobox protein 6, transcript variant 1 (from RefSeq NM_008500.2) ENSMUST00000112960.1 ENSMUST00000112960.2 ENSMUST00000112960.3 ENSMUST00000112960.4 ENSMUST00000112960.5 ENSMUST00000112960.6 ENSMUST00000112960.7 H9H9T0 H9H9T0_MOUSE Lhx6 NM_008500 uc008jlf.1 uc008jlf.2 uc008jlf.3 Nucleus DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc008jlf.1 uc008jlf.2 uc008jlf.3 
ENSMUST00000112971.2 Atg4a ENSMUST00000112971.2 autophagy related 4A, cysteine peptidase, transcript variant 1 (from RefSeq NM_174875.5) ATG4A_MOUSE Apg4a Atg4a Autl2 ENSMUST00000112971.1 NM_174875 Q811B8 Q8C9S8 uc057mcf.1 uc057mcf.2 uc057mcf.3 Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3. In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C- terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity. Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore- endoplasmic reticulum contacts during the lipid transfer phase of mitophagy. Reaction=[protein]-C-terminal L-amino acid-glycyl- phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid- glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:67548, Rhea:RHEA-COMP:17323, Rhea:RHEA-COMP:17324, ChEBI:CHEBI:15377, ChEBI:CHEBI:64612, ChEBI:CHEBI:172940, ChEBI:CHEBI:172941; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67549; Evidence=; Inhibited by N-ethylmaleimide. Redox-regulated during autophagy since reducing conditions activate ATG4A whereas an oxidizing environment such as the presence of H(2)O(2) inhibits its activity. Interacts with ATG9A; the interaction is direct. Cytoplasm The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins. Required for proteolytic activation and delipidation of ATG8 proteins. Belongs to the peptidase C54 family. cysteine-type endopeptidase activity cytoplasm proteolysis autophagy peptidase activity cysteine-type peptidase activity protein transport hydrolase activity uc057mcf.1 uc057mcf.2 uc057mcf.3 
ENSMUST00000112979.4 Catsperd ENSMUST00000112979.4 cation channel sperm associated auxiliary subunit delta, transcript variant 1 (from RefSeq NM_175350.3) CTSRD_MOUSE Catsperd E7DZL7 E7DZL8 E9Q710 E9Q9F6 ENSMUST00000112979.1 ENSMUST00000112979.2 ENSMUST00000112979.3 NM_175350 Q1JPR3 Q1LZJ6 Q8C5U5 Tmem146 uc008dcs.1 uc008dcs.2 uc008dcs.3 uc008dcs.4 Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation (PubMed:34225353). Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (PubMed:21224844). Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (PubMed:21224844). Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG2, CATSPERD, CATSPERE, CATSPERZ, C2CD6/CATSPERT, SLCO6C1, TMEM249, TMEM262 and EFCAB9 (PubMed:34225353, PubMed:21224844, PubMed:34998468). HSPA1 may be an additional auxiliary complex member (By similarity). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (PubMed:34225353). The auxiliary CATSPERB, CATSPERG2, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively (PubMed:34225353). SLCO6C1 interacts with CATSPERE and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex (PubMed:34225353). C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane (PubMed:34225353). Cell projection, cilium, flagellum membrane ; Single-pass type I membrane protein Note=Specifically located in the principal piece of sperm tail. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Tmem146-l, l; IsoId=E9Q9F6-1; Sequence=Displayed; Name=2; Synonyms=Tmem146-s, s; IsoId=E9Q9F6-2; Sequence=VSP_042980, VSP_042981; Name=3; IsoId=E9Q9F6-3; Sequence=VSP_042982; Testis-specific. Expressed in spermatocytes and spermatids in different stages of spermatogenesis (at protein level). Mice are normal but males are sterile. Male sterility is due to defects in sperm cell hyperactivation and decreased stability of Catsper1. Belongs to the CATSPERD family. Sequence=AAI16634.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC36602.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=EDL38183.1; Type=Erroneous gene model prediction; Evidence=; molecular_function plasma membrane cilium multicellular organism development spermatogenesis membrane integral component of membrane cell differentiation flagellated sperm motility motile cilium CatSper complex cell projection sperm capacitation sperm principal piece uc008dcs.1 uc008dcs.2 uc008dcs.3 uc008dcs.4 
ENSMUST00000112983.8 Dab2ip ENSMUST00000112983.8 disabled 2 interacting protein, transcript variant 7 (from RefSeq NM_001290641.1) A2AUW9 A2AUX2 A5X2X2 B7ZD28 DAB2P_MOUSE ENSMUST00000112983.1 ENSMUST00000112983.2 ENSMUST00000112983.3 ENSMUST00000112983.4 ENSMUST00000112983.5 ENSMUST00000112983.6 ENSMUST00000112983.7 Kiaa1743 NM_001290641 Q3TPD5 Q3UH44 Q3UHC7 Q6JTV1 Q6Y636 Q80T97 uc008jku.1 uc008jku.2 uc008jku.3 uc008jku.4 Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor- mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF- kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta- catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. On plasma membrane, exists in an inactive form complexed with TNFR1; in response to TNF-alpha, dissociates from TNFR1 complex, translocates to cytoplasm and forms part of an intracellular signaling complex comprising TRADD, RIPK1, TRAF2 and MAP3K5. Interacts with DAB1. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF-alpha; this complex formation promotes MAP3K5-JNK activation and subsequent apoptosis. Interacts (via N-terminal domain) with JAK2; the interaction occurs in a IFNG/IFN-gamma-dependent manner and inhibits JAK2 autophosphorylation activity. Interacts (via C2 domain) with GSK3B; the interaction stimulates GSK3B kinase activation. Interacts (via C2 domain) with PPP2CA. Interacts (via proline-rich motif) with a regulatory p85 subunit (via SH3 domain) of the PI3K complex; the interaction inhibits the PI3K-AKT complex activity in a TNF-alpha-dependent manner in prostate cancer (PCa) cells. Interacts with AKT1; the interaction is increased in a TNF-alpha-induced manner. Interacts (via C2 domain and active form preferentially) with KDR/VEGFR2 (tyrosine-phosphorylated active form preferentially); the interaction occurs at the late phase of VEGFA response and inhibits KDR/VEGFR2 activity. Interacts (via N-terminus C2 domain) with MAP3K5 ('Ser-966' dephosphorylated form preferentially); the interaction occurs in a TNF-alpha-induced manner. Interacts (via Ras-GAP domain) with the catalytic subunit of protein phosphatase PP2A; the interaction occurs in resting endothelial cells, is further enhanced by TNF-alpha stimulation and is required to bridge PP2A to MAP3K5. Interacts (via C- terminus PER domain) with TRAF2 (via zinc fingers); the interaction occurs in a TNF-alpha-dependent manner. Interacts with 14-3-3 proteins; the interaction occurs in a TNF-alpha-dependent manner. Interacts (via Ras-GAP domain) with RIPK1 (via kinase domain); the interaction occurs in a TNF-alpha-dependent manner (By similarity). Interacts (via PH domain) with ERN1. Interacts with TRAF2. Interacts (via NPXY motif) with DAB2 (via PID domain). Q3UHC7; P97318: Dab1; NbExp=3; IntAct=EBI-6306507, EBI-81680; Cytoplasm. Cell membrane ; Peripheral membrane protein Cell projection, dendrite. Note=Colocalizes with TIRAP at the plasma membrane. Colocalizes with ARF6 at the plasma membrane and endocytic vesicles. Translocates from the plasma membrane to the cytoplasm in response to TNF-alpha. Phosphatidylinositol 4-phosphate (PtdIns4P) binding is essential for plasma membrane localization (By similarity). Localized in soma and dendrites of Purkinje cells as well as in scattered cell bodies in the molecular layer of the cerebellum. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3UHC7-1; Sequence=Displayed; Name=2; IsoId=Q3UHC7-2; Sequence=VSP_020956; Name=3; IsoId=Q3UHC7-3; Sequence=VSP_020957; Name=4; Synonyms=Dab2IP-L; IsoId=Q3UHC7-4; Sequence=VSP_046519, VSP_046520; Expressed in vascular endothelium of muscle and aorta, in smooth muscle cells of aorta and epithelial cells of lung. Expressed throughout the brain, including olfactory bulb, hypothalamus, cerebellum and cerebral cortex. Expressed in the soma and processes of neurons in a variety of brain structures, including the developing cerebral cortex, CA1 pyramidal neurons and Purkinje cells. Poorly expressed in medulloblastoma cells compared to cerebellar precursor proliferating progenitor cells (at protein level). Highly expressed in the brain, salivary gland, and testis; moderate expression in kidney and heart. Low expression in the lung, seminal vesicle, ventral prostate, epididymis, liver, and bladder. Very low expression in the coagulation gland and skeleton muscles. Lowest expression seen in spleen. Expressed in cortical plate neurons at 16 dpc. Expressed in the neocortex, including the cortical plate (CP) at 16.5 dpc, onward (at protein level). Expressed in brain at 13.5 dpc, onward. Expressed during embryogenesis in the vasculature. Down-regulated in prostate cancer and medulloblastoma. Exists in a closed inactive form by an intramolecular interaction between the N- and the C-terminal domains. The proline-rich motif is critical both for PI3K-AKT activity inhibition and MAP3K5 activation. The PH and C2 domains are necessary for the binding to phosphatidylinositol phosphate. The Ras-GAP domain is necessary for its tumor-suppressive function (By similarity). The C2 and GAP domains constitutively bind to MAP3K5 and facilitate the release of 14-3-3 proteins from MAP3K5. The PH and Ras-GAP domains, but not the NPXY motif, are crucial for its cell membrane localization and neuronal migration function. The PH domain is necessary but not sufficient to activate the JNK signaling pathway through ERN1. In response to TNF-alpha-induction, phosphorylated at Ser-728; phosphorylation leads to a conformational change, and thus, increases its association with 14-3-3 proteins, MAP3K5, RIPK1 and TRAF2 in endothelial cells; also stimulates regulatory p85 subunit sequestring and PI3K-p85 complex activity inhibition. Mice are viable and fertile but show a number of cerebellar abnormalities such as a delay in the Purkinje cell (PC) dendrites development and a disruption of late-born cortical neurons migration. Develope a prostate hyperplasia in epithelial compartment at 6 months of age. Show normal vasculature development but enhanced inflammatory angiogenesis. Sequence=AAQ77379.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAQ77380.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAQ77381.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter activation of MAPKKK activity angiogenesis negative regulation of protein phosphorylation immune system process GTPase activator activity death receptor binding protein binding cytoplasm plasma membrane apoptotic process inflammatory response response to unfolded protein cell cycle signal transduction I-kappaB phosphorylation activation of JUN kinase activity multicellular organism development negative regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors negative regulation of endothelial cell migration negative regulation of epithelial cell migration negative regulation of epithelial to mesenchymal transition positive regulation of neuron projection development negative regulation of phosphatidylinositol 3-kinase signaling membrane negative regulation of angiogenesis SH3 domain binding kinase binding protein kinase binding cell motility involved in cerebral cortex radial glia guided migration layer formation in cerebral cortex endocytic vesicle negative regulation of cell growth axon dendrite negative regulation of vascular endothelial growth factor receptor signaling pathway mitogen-activated protein kinase kinase binding mitogen-activated protein kinase kinase kinase binding negative regulation of NF-kappaB transcription factor activity phosphatidylinositol-3-phosphate binding neuronal cell body membrane negative regulation of toll-like receptor 4 signaling pathway negative regulation of GTPase activity tube formation signaling adaptor activity cellular response to vascular endothelial growth factor stimulus phosphatidylinositol 3-kinase regulatory subunit binding vascular endothelial growth factor receptor-2 signaling pathway reelin-mediated signaling pathway regulation of growth negative regulation of epidermal growth factor receptor signaling pathway identical protein binding protein homodimerization activity cell projection neuronal cell body positive regulation of apoptotic process regulation of GTPase activity regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling vascular endothelial growth factor receptor 2 binding regulation of protein complex assembly negative regulation of MAP kinase activity positive regulation of MAPK cascade regulation of protein heterodimerization activity positive regulation of JUN kinase activity positive regulation of GTPase activity phosphatidylinositol 3-kinase binding negative regulation of phosphatidylinositol 3-kinase activity cellular protein catabolic process cerebellar mossy fiber climbing fiber macromolecular complex binding innate immune response positive regulation of protein catabolic process negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade negative regulation of Ras protein signal transduction protein N-terminus binding negative regulation of fibroblast proliferation neuron projection morphogenesis positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation protein phosphatase 2A binding intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress phosphatidylinositol-4-phosphate binding negative regulation of G0 to G1 transition negative regulation of ERK1 and ERK2 cascade positive regulation of cell cycle arrest cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus 14-3-3 protein binding negative regulation of protein serine/threonine kinase activity positive regulation of protein serine/threonine kinase activity negative regulation of canonical Wnt signaling pathway positive regulation of synapse maturation positive regulation of dendrite development regulation of p38MAPK cascade negative regulation of vascular endothelial growth factor signaling pathway positive regulation of proteasomal protein catabolic process negative regulation of cellular protein catabolic process parallel fiber AIP1-IRE1 complex positive regulation of neuron migration positive regulation of apoptotic signaling pathway Toll-like receptor 4 binding uc008jku.1 uc008jku.2 uc008jku.3 uc008jku.4 
ENSMUST00000112984.4 Ms4a3 ENSMUST00000112984.4 membrane-spanning 4-domains, subfamily A, member 3 (from RefSeq NM_133246.5) ENSMUST00000112984.1 ENSMUST00000112984.2 ENSMUST00000112984.3 Htm4 MS4A3_MOUSE NM_133246 Q920C4 Q99MX6 uc008gsp.1 uc008gsp.2 uc008gsp.3 uc008gsp.4 This gene encodes a member of the membrane-spanning-four (MS4) protein group, that contain a four-transmembrane protein structure. This gene is expressed in developing hematopoietic cells and has also been observed in some regions of the adult brain. Expression of the human ortholog of this gene has also been observed in some human cancer cell lines. This protein may play a role in cell cycle regulation, and interactions have been demonstrated between Ms4a3 and KAP phosphatase. [provided by RefSeq, Jul 2014]. ##Evidence-Data-START## Transcript exon combination :: AF321128.1, AY184359.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP) (By similarity). Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes (By similarity). Membrane; Multi-pass membrane protein. Expressed at low levels only in specific immune tissues, such as, spleen, bone marrow and peripheral blood leukocytes. The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity. Belongs to the MS4A family. protein binding cytoplasm biological_process membrane integral component of membrane regulation of cell cycle uc008gsp.1 uc008gsp.2 uc008gsp.3 uc008gsp.4 
ENSMUST00000112990.8 Mid2 ENSMUST00000112990.8 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; (from UniProt B1AVF4) B1AVF4 B1AVF4_MOUSE ENSMUST00000112990.1 ENSMUST00000112990.2 ENSMUST00000112990.3 ENSMUST00000112990.4 ENSMUST00000112990.5 ENSMUST00000112990.6 ENSMUST00000112990.7 Mid2 Y18881 uc292qvd.1 uc292qvd.2 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Cytoplasm, cytoskeleton microtubule microtubule binding zinc ion binding positive regulation of autophagy negative regulation of viral transcription protein localization to microtubule protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response negative regulation of viral entry into host cell metal ion binding protein heterodimerization activity positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity phosphoprotein binding negative regulation of viral release from host cell uc292qvd.1 uc292qvd.2 
ENSMUST00000113010.9 4930402F06Rik ENSMUST00000113010.9 RIKEN cDNA 4930402F06 gene, transcript variant 1 (from RefSeq NM_001080709.3) 4930402F06Rik A2AUQ8 A2AUQ8_MOUSE ENSMUST00000113010.1 ENSMUST00000113010.2 ENSMUST00000113010.3 ENSMUST00000113010.4 ENSMUST00000113010.5 ENSMUST00000113010.6 ENSMUST00000113010.7 ENSMUST00000113010.8 NM_001080709 uc008jki.1 uc008jki.2 uc008jki.3 uc008jki.4 Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mn(2+) ion per subunit. ; Belongs to the glycosyltransferase 6 family. Golgi apparatus carbohydrate metabolic process membrane transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups lipid glycosylation vesicle uc008jki.1 uc008jki.2 uc008jki.3 uc008jki.4 
ENSMUST00000113011.9 Rbm41 ENSMUST00000113011.9 RNA binding motif protein 41, transcript variant 4 (from RefSeq NM_001290630.1) A2AG09 A2AG09_MOUSE ENSMUST00000113011.1 ENSMUST00000113011.2 ENSMUST00000113011.3 ENSMUST00000113011.4 ENSMUST00000113011.5 ENSMUST00000113011.6 ENSMUST00000113011.7 ENSMUST00000113011.8 NM_001290630 Rbm41 uc009uks.1 uc009uks.2 uc009uks.3 uc009uks.4 nucleic acid binding RNA binding uc009uks.1 uc009uks.2 uc009uks.3 uc009uks.4 
ENSMUST00000113026.2 Rnf128 ENSMUST00000113026.2 ring finger protein 128, transcript variant 1 (from RefSeq NM_023270.5) ENSMUST00000113026.1 Grail Greul1 MNCb-3816 NM_023270 Q3UJY0 Q9CVG1 Q9D304 Q9DBN3 Q9JJF8 RN128_MOUSE uc009uki.1 uc009uki.2 uc009uki.3 E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down- regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Endomembrane system ; Single-pass membrane protein Cytoplasm, cytoskeleton Cytoplasm, perinuclear region Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A. Expressed in brain, kidney, heart, liver, ovary, testis and thymus. Expression increased as early as 4 hours by 5- to 7- fold in anergized cultures as compared to resting or activated cells. At 6.0 dpc, expressed in both the extraembryonic endoderm and extraembryonic ectoderm. After the beginning of gastrulation, expression remains extraembryonic, and is mostly confined to the visceral endoderm. At 8.5 dpc, expression appears within the mesodermally derived allantois, and is highly expressed in the epithelial layer of the yolk sac. At 9.5 dpc, expressed in the hindgut and adjoining yolk sac. At stage 10 dpc, appears to be widely expressed throughout the embryo with higher expression within the branchial arches and within intersomitic endothelial cells. Induced under anergic conditions. Up-regulated during T-cell anergy induction following signaling through the T-cell antigen receptor. Binding to E2 ubiquitin-conjugating enzyme requires an intact RING finger domain. Auto-ubiquitinated. Controls the development of T-cell clonal anergy by ubiquitination. cytoplasm late endosome endoplasmic reticulum Golgi apparatus cytoskeleton ubiquitin-dependent protein catabolic process endomembrane system membrane integral component of membrane protein ubiquitination transferase activity regulation of protein stability negative regulation of cytokine biosynthetic process metal ion binding perinuclear region of cytoplasm ubiquitin protein ligase activity uc009uki.1 uc009uki.2 uc009uki.3 
ENSMUST00000113028.2 Dipk2a ENSMUST00000113028.2 divergent protein kinase domain 2A (from RefSeq NM_001033145.2) DIK2A_MOUSE E9Q9E9 ENSMUST00000113028.1 NM_001033145 Q3USZ8 uc009rax.1 uc009rax.2 May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PI3-kinase signaling cascade. Golgi apparatus. Cytoplasmic vesicle, COPI-coated vesicle. Secreted. Expressed in heart, brain, liver, spleen, kidney, lung, thymus, testis, ovary and muscle. As early as 12.5 dpc to 16.5 dpc, intense expression is restricted to mesenchymal condensations, which form the different cartilage elements of the developing skeleton. At 12.5 dpc, strongly expressed in all vertebrae, heart ventricle, dental follicle, interdigital tissue, tongue and cartilages of the basioccipital bone, maxilla, mandible and the region of the future nasal septum. At 14.5 and 16.5 dpc, expressed in ribs, long bones, interdigital tissue, metatarsals, dental follicle, cartilages of the mandible and nasal septum as well as vertebrae with stronger expression in posterior vertebrae. At 16.5 dpc, also expressed in paw bones and, in vertebrae, the expression is limited to mainly columnar, proliferating chondrocytes. At 4 days postnatal, intense expression in nasal cartilages, hair, dental and vibrissa follicles. Belongs to the DIPK family. Golgi membrane molecular_function extracellular region extracellular space Golgi apparatus regulation of phosphatidylinositol 3-kinase signaling COPI vesicle coat COPI-coated vesicle cytoplasmic vesicle negative regulation of smooth muscle cell apoptotic process vesicle targeting, to, from or within Golgi cardiac muscle cell proliferation uc009rax.1 uc009rax.2 
ENSMUST00000113032.8 Cntrl ENSMUST00000113032.8 centriolin, transcript variant 1 (from RefSeq NM_012018.2) Cep110 Cntrl ENSMUST00000113032.1 ENSMUST00000113032.2 ENSMUST00000113032.3 ENSMUST00000113032.4 ENSMUST00000113032.5 ENSMUST00000113032.6 ENSMUST00000113032.7 NM_012018 R4GML3 R4GML3_MOUSE uc008jjr.1 uc008jjr.2 uc008jjr.3 uc008jjr.4 uc008jjr.5 uc008jjr.6 centrosome microtubule organizing center cytosol cytoskeletal protein binding regulation of cytoskeleton organization uc008jjr.1 uc008jjr.2 uc008jjr.3 uc008jjr.4 uc008jjr.5 uc008jjr.6 
ENSMUST00000113045.9 Pwwp3b ENSMUST00000113045.9 PWWP domain containing 3B, transcript variant 5 (from RefSeq NM_175541.3) B1AW67 ENSMUST00000113045.1 ENSMUST00000113045.2 ENSMUST00000113045.3 ENSMUST00000113045.4 ENSMUST00000113045.5 ENSMUST00000113045.6 ENSMUST00000113045.7 ENSMUST00000113045.8 Mum1l1 NM_175541 PWP3B_MOUSE Q0VBL8 Q4VA55 Q7TSI2 Q8BS63 uc012hpe.1 uc012hpe.2 Belongs to the PWWP3A family. Sequence=BAC28940.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function biological_process uc012hpe.1 uc012hpe.2 
ENSMUST00000113046.2 4933428M09Rik ENSMUST00000113046.2 RIKEN cDNA 4933428M09 gene (from RefSeq NM_001357856.1) 4933428M09Rik ENSMUST00000113046.1 NM_001357856 Q9D3X3 Q9D3X3_MOUSE uc292qtj.1 uc292qtj.2 molecular_function cellular_component biological_process uc292qtj.1 uc292qtj.2 
ENSMUST00000113055.9 Shroom3 ENSMUST00000113055.9 shroom family member 3, transcript variant 1 (from RefSeq NM_015756.2) E9QMY5 E9QMY5_MOUSE ENSMUST00000113055.1 ENSMUST00000113055.2 ENSMUST00000113055.3 ENSMUST00000113055.4 ENSMUST00000113055.5 ENSMUST00000113055.6 ENSMUST00000113055.7 ENSMUST00000113055.8 NM_015756 Shroom3 uc008ydt.1 uc008ydt.2 uc008ydt.3 Cytoplasm, cytoskeleton Belongs to the shroom family. cell morphogenesis neural tube closure epithelial cell development actin binding actin filament binding uc008ydt.1 uc008ydt.2 uc008ydt.3 
ENSMUST00000113063.8 Il1rapl2 ENSMUST00000113063.8 interleukin 1 receptor accessory protein-like 2 (from RefSeq NM_030688.2) ENSMUST00000113063.1 ENSMUST00000113063.2 ENSMUST00000113063.3 ENSMUST00000113063.4 ENSMUST00000113063.5 ENSMUST00000113063.6 ENSMUST00000113063.7 IRPL2_MOUSE NM_030688 Q9ER66 Q9ERS6 uc009ujv.1 uc009ujv.2 uc009ujv.3 uc009ujv.4 Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302; Evidence=; Membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ERS6-1; Sequence=Displayed; Name=2; IsoId=Q9ERS6-2; Sequence=VSP_008056, VSP_008057; Detected in fetal brain after day 12.5, in particular in parts of the diencephalon and in the basal plate of the spinal cord. In postnatal brain detected in cerebral cortex, olfactory bulb, in the CA1 region of the hippocampus and in Purkinje cells of the Xth cerebellar lobule. The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. [Isoform 2]: May be due to an intron retention. Belongs to the interleukin-1 receptor family. interleukin-1, Type II, blocking receptor activity signal transduction membrane integral component of membrane cytokine-mediated signaling pathway glutamatergic synapse regulation of presynapse assembly uc009ujv.1 uc009ujv.2 uc009ujv.3 uc009ujv.4 
ENSMUST00000113064.8 Traf1 ENSMUST00000113064.8 TNF receptor-associated factor 1, transcript variant 1 (from RefSeq NM_009421.4) ENSMUST00000113064.1 ENSMUST00000113064.2 ENSMUST00000113064.3 ENSMUST00000113064.4 ENSMUST00000113064.5 ENSMUST00000113064.6 ENSMUST00000113064.7 NM_009421 P39428 Q8CE28 TRAF1_MOUSE uc008jjk.1 uc008jjk.2 uc008jjk.3 uc008jjk.4 Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin- protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity). Homotrimer (By similarity). Heterotrimer with TRAF2 (PubMed:8069916). Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2 (PubMed:8069916, PubMed:9104814, PubMed:18429822). Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2. Interacts with MAP3K14 (By similarity). Interacts with NFATC2IP, TRAFD1 and with HIVEP3 (PubMed:11804591, PubMed:16352630, PubMed:18849341). Interacts with GPS2 (PubMed:22424771). P39428; P50247: Ahcy; NbExp=3; IntAct=EBI-520123, EBI-646982; P39428; Q9Z104: Hmg20b; NbExp=3; IntAct=EBI-520123, EBI-646920; P39428; Q8C886: Plekhn1; NbExp=6; IntAct=EBI-520123, EBI-646708; P39428; P70347-1: Tank; NbExp=12; IntAct=EBI-520123, EBI-646125; P39428; Q924A0: Tcf7l2; NbExp=6; IntAct=EBI-520123, EBI-646713; Cytoplasm. The coiled coil domain mediates homo- and hetero- oligomerization. The MATH/TRAF domain binds to receptor cytoplasmic domains. Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of NF-kappa-B in response to TNF signaling. Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation (By similarity). Ubiquitinated by the SCF(FBXL2) complex, leading to its degradation by the proteasome (PubMed:23542741). No visible phenotype. Mice have normal B-cell proliferation and antibody response, but increased T-cell proliferation in response to CD3 signaling. Their T-cells show enhanced activation of JNK and NF-kappa-B. Mice are highly susceptible to TNF-induced skin necrosis. Lacks a RING domain and has therefore no E3 ubiquitin-protein ligase activity by itself. tumor necrosis factor receptor binding protein binding cytoplasm apoptotic process signal transduction zinc ion binding cytoplasmic side of plasma membrane ubiquitin protein ligase binding thioesterase binding macromolecular complex CD40 receptor complex identical protein binding regulation of apoptotic process positive regulation of NF-kappaB transcription factor activity regulation of extrinsic apoptotic signaling pathway uc008jjk.1 uc008jjk.2 uc008jjk.3 uc008jjk.4 
ENSMUST00000113066.9 Esx1 ENSMUST00000113066.9 Nucleus (from UniProt A2AG22) A2AG22 A2AG22_MOUSE AF004211 ENSMUST00000113066.1 ENSMUST00000113066.2 ENSMUST00000113066.3 ENSMUST00000113066.4 ENSMUST00000113066.5 ENSMUST00000113066.6 ENSMUST00000113066.7 ENSMUST00000113066.8 Esx1 uc292qso.1 uc292qso.2 Nucleus RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding blood vessel development DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding labyrinthine layer morphogenesis labyrinthine layer blood vessel development uc292qso.1 uc292qso.2 
ENSMUST00000113068.9 Cutal ENSMUST00000113068.9 cutA divalent cation tolerance homolog-like, transcript variant 1 (from RefSeq NM_030021.3) Cutal D730039F16Rik ENSMUST00000113068.1 ENSMUST00000113068.2 ENSMUST00000113068.3 ENSMUST00000113068.4 ENSMUST00000113068.5 ENSMUST00000113068.6 ENSMUST00000113068.7 ENSMUST00000113068.8 NM_030021 Q9D1U5 Q9D1U5_MOUSE uc008jjf.1 uc008jjf.2 uc008jjf.3 uc008jjf.4 Homotrimer. Belongs to the CutA family. copper ion binding cellular_component biological_process response to metal ion membrane integral component of membrane uc008jjf.1 uc008jjf.2 uc008jjf.3 uc008jjf.4 
ENSMUST00000113071.2 Tmsb15b1 ENSMUST00000113071.2 thymosin beta 15b1 (from RefSeq NM_001081983.1) A2AF33 A2AF33_MOUSE ENSMUST00000113071.1 NM_001081983 Tmsb15b1 uc009uji.1 uc009uji.2 This gene is part of tandem duplication; the other copy of this gene is about 1.5 kb away. Readthrough transcripts that include two exons transcribed from each gene exist. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AA269408.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Cytoplasm, cytoskeleton Belongs to the thymosin beta family. actin binding actin monomer binding cytoplasm cytoskeleton actin filament organization regulation of cell migration sequestering of actin monomers uc009uji.1 uc009uji.2 
ENSMUST00000113089.8 Cidec ENSMUST00000113089.8 cell death-inducing DFFA-like effector c, transcript variant 2 (from RefSeq NM_001301295.1) CIDEC_MOUSE Cidec ENSMUST00000113089.1 ENSMUST00000113089.2 ENSMUST00000113089.3 ENSMUST00000113089.4 ENSMUST00000113089.5 ENSMUST00000113089.6 ENSMUST00000113089.7 Fsp27 NM_001301295 P56198 Q499X5 Q8BNV7 uc009dgc.1 uc009dgc.2 uc009dgc.3 Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:18334488, PubMed:22144693, PubMed:26733203, PubMed:30361435, PubMed:36477540). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:18334488, PubMed:18682832, PubMed:22144693, PubMed:26733203). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (PubMed:18334488, PubMed:22144693). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (PubMed:18334488, PubMed:22144693). Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1 (PubMed:23481402). May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH (PubMed:22245780). When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment (By similarity). Reaction=a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out); Xref=Rhea:RHEA:39011, ChEBI:CHEBI:64615; Evidence=; Homodimer (PubMed:24025675, PubMed:23481402). Homooligomer; undergoes liquid-liquid phase separation (LLPS) via its N-terminus, facilitating lipid droplet fusion, occurs at the lipid droplet contact sites (PubMed:34508658). Interacts with CIDEA (By similarity). Interacts with PLIN1 (PubMed:23481402). Interacts with NFAT5; this interaction is direct and retains NFAT5 in the cytoplasm (By similarity). Interacts with CEBPB (PubMed:22245780). Interacts with isoform CLSTN3beta of CLSTN3; inhibiting the lipid transferase activity of CIDEC (PubMed:36477540). Lipid droplet doplasmic reticulum Nucleus Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites. Expressed almost exclusively in adipose tissue, including subcutaneous and epididymal white adipose tissue (at protein level) (PubMed:1339452, PubMed:12910269, PubMed:18654663, PubMed:18682832, PubMed:22245780). Although abundantly present in brown adipose tissue at the mRNA level, the protein is almost undetectable in this tissue, or at moderate levels (PubMed:12910269, PubMed:18654663, PubMed:22245780). Expressed in the mammary gland, in stromal adipose tissue, but becomes undetectable at the end of pregnancy and during lactation (at protein level) (PubMed:22245780). Expressed at low levels in skeletal muscle and heart (PubMed:23233732). Up-regulated during differentiation into adipocytes in various cell lines, including TA1 and 3T3-L1 (PubMed:1339452, PubMed:18334488, PubMed:18654663, PubMed:22245780). Decreases in the mammary gland during pregnancy from day 14.5 until 18.5, when it becomes hardly detectable, and during lactation (PubMed:1339452, PubMed:18334488, PubMed:18654663, PubMed:22245780). Up-regulated under conditions that enhance triacylglycerol deposition, including rosiglitazone treatment and high-fat diet (PubMed:18509062, PubMed:20089860). This up-regulation is mediated by PPARG (PubMed:20089860). Up-regulated by isoproterenol, a beta-agonist, and oleic acid treatment (PubMed:20089860). This induction is due to protein stabilization (PubMed:20089860). Down-regulated upon hypertonic conditions (PubMed:23233732). The RKKR polybasic motif mediates binding to acidic phospholipids, such as phosphatidic acid, phosphatidylinositol and phosphatidylserine, inhibiting the ability to mediate lipid droplet fusion. The CIDE-N domain is involved in homodimerization which is crucial for its function in promoting lipid exchange and transfer. Ubiquitinated and targeted to proteasomal degradation, resulting in a short half-life (about 15 minutes in 3T3-L1 cells) (PubMed:20089860). Protein stability depends on triaclyglycerol synthesis, fatty acid availability and lipid droplet formation (PubMed:20089860). Mutant animals are born in a Mendelian ratio and appear physically normal at birth (PubMed:18654663). Mice display increased energy expenditure, lower levels of plasma triglycerides and free fatty acids (PubMed:18654663, PubMed:18682832). The body weights of wild-type and mutant mice fed a standard diet do not differ up to 14 weeks of age, nor does food intake (PubMed:18654663). From 16 weeks of age, the body weight of mutant mice significantly decreases compared with that of wild-type mice (PubMed:18654663, PubMed:18682832). When animals are fed a high-fat diet, the gain in body weight is significantly smaller for mutant mice than for wild-type (PubMed:18654663). Under these feeding conditions, mutant mice are also protected from insulin resistance and from accumulation of fat in the liver (PubMed:18654663). The body temperature do not differ significantly between mutant and wild-type mice maintained at room temperature, but the basal rate of oxygen consumption is significantly increased in mutants (PubMed:18654663). Belongs to the CIDE family. molecular_function nucleus endoplasmic reticulum lipid particle cytosol apoptotic process lipid particle organization execution phase of apoptosis uc009dgc.1 uc009dgc.2 uc009dgc.3 
ENSMUST00000113092.9 Rpusd3 ENSMUST00000113092.9 RNA pseudouridylate synthase domain containing 3, transcript variant 1 (from RefSeq NM_001033204.1) ENSMUST00000113092.1 ENSMUST00000113092.2 ENSMUST00000113092.3 ENSMUST00000113092.4 ENSMUST00000113092.5 ENSMUST00000113092.6 ENSMUST00000113092.7 ENSMUST00000113092.8 NM_001033204 Q14AI6 Q3UZF6 Q8BVS3 Q8CHZ5 RUSD3_MOUSE uc009dfy.1 uc009dfy.2 uc009dfy.3 Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post- transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis. Reaction=a uridine in mRNA = a pseudouridine in mRNA; Xref=Rhea:RHEA:56644, Rhea:RHEA-COMP:14658, Rhea:RHEA-COMP:14659, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Mitochondrion matrix Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14AI6-1; Sequence=Displayed; Name=2; IsoId=Q14AI6-2; Sequence=VSP_027871; Belongs to the pseudouridine synthase RluA family. Sequence=BAE21901.1; Type=Frameshift; Evidence=; pseudouridine synthesis RNA binding mitochondrion mitochondrial matrix mRNA processing RNA modification pseudouridine synthase activity isomerase activity positive regulation of mitochondrial translation uc009dfy.1 uc009dfy.2 uc009dfy.3 
ENSMUST00000113093.5 Cxcl9 ENSMUST00000113093.5 C-X-C motif chemokine ligand 9 (from RefSeq NM_008599.4) CXCL9_MOUSE ENSMUST00000113093.1 ENSMUST00000113093.2 ENSMUST00000113093.3 ENSMUST00000113093.4 Mig NM_008599 P18340 Q8C9J0 Q99J60 Scyb9 uc008ycv.1 uc008ycv.2 uc008ycv.3 uc008ycv.4 May be a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Secreted. By interferon gamma. Belongs to the intercrine alpha (chemokine CxC) family. cytokine activity extracellular region extracellular space chemotaxis defense response inflammatory response immune response adenylate cyclase-activating G-protein coupled receptor signaling pathway chemokine activity response to bacterium external side of plasma membrane neutrophil chemotaxis leukocyte chemotaxis regulation of cell proliferation positive regulation of myoblast differentiation CXCR3 chemokine receptor binding positive regulation of release of sequestered calcium ion into cytosol defense response to virus chemokine-mediated signaling pathway cellular response to lipopolysaccharide positive regulation of myoblast fusion uc008ycv.1 uc008ycv.2 uc008ycv.3 uc008ycv.4 
ENSMUST00000113097.8 Morf4l2 ENSMUST00000113097.8 mortality factor 4 like 2, transcript variant 5 (from RefSeq NM_001168228.1) A2AEB2 ENSMUST00000113097.1 ENSMUST00000113097.2 ENSMUST00000113097.3 ENSMUST00000113097.4 ENSMUST00000113097.5 ENSMUST00000113097.6 ENSMUST00000113097.7 Kiaa0026 MO4L2_MOUSE NM_001168228 Q3UL62 Q6DIB1 Q6ZQK7 Q8C201 Q8C6C2 Q9R0Q4 Sid393 uc009uiw.1 uc009uiw.2 uc009uiw.3 uc009uiw.4 uc009uiw.5 uc009uiw.6 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity). Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors (By similarity). Nucleus histone acetyltransferase complex nucleus nucleoplasm nucleolus plasma membrane DNA repair chromatin organization chromatin silencing regulation of transcription, DNA-templated cellular response to DNA damage stimulus histone acetylation histone deacetylation NuA4 histone acetyltransferase complex regulation of growth histone H4 acetylation histone H2A acetylation positive regulation of transcription from RNA polymerase II promoter positive regulation of striated muscle cell differentiation uc009uiw.1 uc009uiw.2 uc009uiw.3 uc009uiw.4 uc009uiw.5 uc009uiw.6 
ENSMUST00000113102.10 Naaa ENSMUST00000113102.10 N-acylethanolamine acid amidase, transcript variant 1 (from RefSeq NM_025972.4) Asahl ENSMUST00000113102.1 ENSMUST00000113102.2 ENSMUST00000113102.3 ENSMUST00000113102.4 ENSMUST00000113102.5 ENSMUST00000113102.6 ENSMUST00000113102.7 ENSMUST00000113102.8 ENSMUST00000113102.9 NAAA_MOUSE NM_025972 Naaa Q5KTC6 Q99KM3 Q9D6B4 Q9D7V9 uc008ycq.1 uc008ycq.2 uc008ycq.3 uc008ycq.4 Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N- myristoylethanolamine > N-stearoylethanolamine > N-oleoylethanolamine > N-linoleoylethanolamine > N-arachidonoylethanolamine. Reaction=H2O + N-hexadecanoylethanolamine = ethanolamine + hexadecanoate; Xref=Rhea:RHEA:45064, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:57603, ChEBI:CHEBI:71464; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45065; Evidence=; Reaction=H2O + N-(long-chain fatty acyl)ethanolamine = a long-chain fatty acid + ethanolamine; Xref=Rhea:RHEA:17505, ChEBI:CHEBI:15377, ChEBI:CHEBI:15897, ChEBI:CHEBI:57560, ChEBI:CHEBI:57603; EC=3.5.1.60; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17506; Evidence=; Reaction=H2O + N-dodecanoylethanolamine = dodecanoate + ethanolamine; Xref=Rhea:RHEA:45456, ChEBI:CHEBI:15377, ChEBI:CHEBI:18262, ChEBI:CHEBI:57603, ChEBI:CHEBI:85263; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45457; Evidence=; Reaction=H2O + N-tetradecanoylethanolamine = ethanolamine + tetradecanoate; Xref=Rhea:RHEA:45452, ChEBI:CHEBI:15377, ChEBI:CHEBI:30807, ChEBI:CHEBI:57603, ChEBI:CHEBI:85262; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45453; Evidence=; Reaction=an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine; Xref=Rhea:RHEA:20856, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868, ChEBI:CHEBI:52639, ChEBI:CHEBI:57756; EC=3.5.1.23; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20857; Evidence=; Reaction=H2O + N-hexadecanoylsphing-4-enine = hexadecanoate + sphing-4- enine; Xref=Rhea:RHEA:38891, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:57756, ChEBI:CHEBI:72959; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38892; Evidence=; Reaction=H2O + N-dodecanoylsphing-4-enine = dodecanoate + sphing-4- enine; Xref=Rhea:RHEA:41291, ChEBI:CHEBI:15377, ChEBI:CHEBI:18262, ChEBI:CHEBI:57756, ChEBI:CHEBI:72956; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41292; Evidence=; Lipid metabolism; fatty acid metabolism. Heterodimer of an alpha and a beta subunit, produced by autocatalytic cleavage. Lysosome Membrane ; Peripheral membrane protein N-glycosylated (PubMed:30301806). Tunicamycin treatment causes a reduction in specific activity against N-palmitoylethanolamine (By similarity). Autoproteolytic cleavage at pH 4.5 gives rise to the alpha and beta subunit (PubMed:30301806). Cleavage gives rise to a conformation change that activates the enzyme. The same catalytic Cys residue mediates the autoproteolytic cleavage and subsequent hydrolysis of lipid substrates (By similarity). Belongs to the acid ceramidase family. Sequence=BAB29350.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; cytoplasm lysosome lipid metabolic process fatty acid metabolic process transcription factor binding membrane lipid catabolic process hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds fatty acid amide hydrolase activity extrinsic component of membrane N-acylethanolamine metabolic process uc008ycq.1 uc008ycq.2 uc008ycq.3 uc008ycq.4 
ENSMUST00000113105.3 Kir3dl1 ENSMUST00000113105.3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1, transcript variant 1 (from RefSeq NM_177749.4) ENSMUST00000113105.1 ENSMUST00000113105.2 Kir3dl1 NM_177749 Q673W4 Q673W4_MOUSE uc009uio.1 uc009uio.2 uc009uio.3 uc009uio.4 membrane integral component of membrane uc009uio.1 uc009uio.2 uc009uio.3 uc009uio.4 
ENSMUST00000113108.8 Kir3dl2 ENSMUST00000113108.8 Kir3dl2 (from geneSymbol) AK046171 D3YWF2 ENSMUST00000113108.1 ENSMUST00000113108.2 ENSMUST00000113108.3 ENSMUST00000113108.4 ENSMUST00000113108.5 ENSMUST00000113108.6 ENSMUST00000113108.7 Kir3dl1 Kir3dl2 Q673W2 Q673W2_MOUSE uc292qqr.1 uc292qqr.2 molecular_function cellular_component biological_process membrane integral component of membrane uc292qqr.1 uc292qqr.2 
ENSMUST00000113110.5 Mthfsl ENSMUST00000113110.5 5, 10-methenyltetrahydrofolate synthetase-like, transcript variant 10 (from RefSeq NR_177216.1) ENSMUST00000113110.1 ENSMUST00000113110.2 ENSMUST00000113110.3 ENSMUST00000113110.4 L7N466 L7N466_MOUSE Mthfsl NR_177216 uc012gya.1 uc012gya.2 uc012gya.3 Reaction=(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10- methenyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:10488, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57455, ChEBI:CHEBI:57457, ChEBI:CHEBI:456216; EC=6.3.3.2; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. nucleotide binding ATP binding folic acid binding cytoplasm mitochondrion mitochondrial matrix cytosol folic acid-containing compound biosynthetic process 5-formyltetrahydrofolate cyclo-ligase activity tetrahydrofolate interconversion metal ion binding uc012gya.1 uc012gya.2 uc012gya.3 
ENSMUST00000113114.10 Trpm8 ENSMUST00000113114.10 Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage- dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. (from UniProt Q8R4D5) AF481480 E9Q165 ENSMUST00000113114.1 ENSMUST00000113114.2 ENSMUST00000113114.3 ENSMUST00000113114.4 ENSMUST00000113114.5 ENSMUST00000113114.6 ENSMUST00000113114.7 ENSMUST00000113114.8 ENSMUST00000113114.9 Ltrpc6 Q148W9 Q8R4D5 TRPM8_MOUSE Trpp8 uc029qrk.1 uc029qrk.2 Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage- dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Interacts (via N-terminus and C-terminus domains) with TCAF1; the interaction stimulates TRPM8 channel activity. Interacts (via N- terminus and C-terminus domains) with TCAF2; the interaction inhibits TRPM8 channel activity (By similarity). Homotetramer. Cell membrane; Multi-pass membrane protein. Membrane raft. Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts. Expressed in dorsal root and trigeminal ganglia. Specifically expressed in a subset of pain- and temperature-sensing neurons. Not expressed in heavily myelinated neurons. Not expressed in neurons expressing TRPA1 or TRPV1. The coiled coil region is required for multimerization. N-glycosylation is not essential for but facilitates cell surface expression, multimerization, association with lipid rafts and ion channel activity. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. ion channel activity calcium channel activity protein binding plasma membrane ion transport cation transport calcium ion transport cellular calcium ion homeostasis response to temperature stimulus response to cold external side of plasma membrane membrane integral component of membrane detection of temperature stimulus ion transmembrane transport identical protein binding membrane raft response to stimulus sensory perception of temperature stimulus thermoception calcium ion transmembrane transport uc029qrk.1 uc029qrk.2 
ENSMUST00000113116.3 Tceal7 ENSMUST00000113116.3 transcription elongation factor A (SII)-like 7 (from RefSeq NM_001127169.1) A3KGA4 ENSMUST00000113116.1 ENSMUST00000113116.2 NM_001127169 TCAL7_MOUSE uc009uih.1 uc009uih.2 uc009uih.3 Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines (By similarity). Nucleus Belongs to the TFS-II family. TFA subfamily. nucleus negative regulation of NF-kappaB transcription factor activity negative regulation of transcription, DNA-templated WW domain binding uc009uih.1 uc009uih.2 uc009uih.3 
ENSMUST00000113122.8 Brpf1 ENSMUST00000113122.8 bromodomain and PHD finger containing, 1, transcript variant 3 (from RefSeq NM_001282127.1) B2RRD7 BRPF1_MOUSE Brpf1 ENSMUST00000113122.1 ENSMUST00000113122.2 ENSMUST00000113122.3 ENSMUST00000113122.4 ENSMUST00000113122.5 ENSMUST00000113122.6 ENSMUST00000113122.7 NM_001282127 uc009dfb.1 uc009dfb.2 uc009dfb.3 Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (By similarity). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (By similarity). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (By similarity). Component of some HBO1 complex composed of KAT7/HBO1, MEAF6, ING5, and BRPF1. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts (via PHD-type zinc finger domains) with unmethylated histone H3 at 'Lys-4' (H3K4me0). Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with ING5; interaction directs BRPF1 to H4K4me3-enriched chromatin at the 5' of active genes. Interacts with KAT7. Nucleus Chromosome Cytoplasm Note=Localization to the nucleus depends on KAT6A, ING5 and MEAF6. Localizes to transcription start sites. Expressed at low level in most tissues, with high expression in the testis and specific regions of the brain. Expressed in the placenta, yolk sac, limb buds, brain, spinal cord, retina, nose, bone and brown fat at the prenatal stages. Acetylated by KAT6A. Embryonic lethality around embryonic day 9.5 caused by arrested vasculogenesis in the yolk sac and embryo proper (PubMed:24646517, PubMed:25773539). Embryos also display abnormal neural tube closure (PubMed:25773539). vasculogenesis neural tube formation nucleic acid binding DNA binding nucleus cytoplasm cytosol plasma membrane chromatin organization common myeloid progenitor cell proliferation histone H3 acetylation histone H3-K23 acetylation positive regulation of transcription, DNA-templated metal ion binding regulation of fibroblast proliferation MOZ/MORF histone acetyltransferase complex histone acetyltransferase activity (H3-K23 specific) uc009dfb.1 uc009dfb.2 uc009dfb.3 
ENSMUST00000113130.8 Mroh2a ENSMUST00000113130.8 maestro heat-like repeat family member 2A (from RefSeq NM_001281466.1) ENSMUST00000113130.1 ENSMUST00000113130.2 ENSMUST00000113130.3 ENSMUST00000113130.4 ENSMUST00000113130.5 ENSMUST00000113130.6 ENSMUST00000113130.7 F5H8M8 F5H8M8_MOUSE Heatr7b1 Mroh2a NM_001281466 uc033fki.1 uc033fki.2 uc033fki.3 uc033fki.1 uc033fki.2 uc033fki.3 
ENSMUST00000113132.9 Pbx3 ENSMUST00000113132.9 pre B cell leukemia homeobox 3, transcript variant h (from RefSeq NR_185190.1) ENSMUST00000113132.1 ENSMUST00000113132.2 ENSMUST00000113132.3 ENSMUST00000113132.4 ENSMUST00000113132.5 ENSMUST00000113132.6 ENSMUST00000113132.7 ENSMUST00000113132.8 NR_185190 O35317 PBX3_MOUSE Q925W2 uc008jii.1 uc008jii.2 uc008jii.3 uc008jii.4 Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'. Interacts with PBXIP1. O35317; P09079: Hoxb5; NbExp=2; IntAct=EBI-26671189, EBI-26671239; Nucleus Event=Alternative splicing; Named isoforms=2; Name=PBX3a; IsoId=O35317-1; Sequence=Displayed; Name=PBX3b; IsoId=O35317-2; Sequence=VSP_008615, VSP_008616; Belongs to the TALE/PBX homeobox family. RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding regulation of respiratory gaseous exchange by neurological system process DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated respiratory gaseous exchange adult locomotory behavior dorsal spinal cord development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter neuron development uc008jii.1 uc008jii.2 uc008jii.3 uc008jii.4 
ENSMUST00000113134.8 Ugt1a6a ENSMUST00000113134.8 UDP glucuronosyltransferase 1 family, polypeptide A6A (from RefSeq NM_145079.3) ENSMUST00000113134.1 ENSMUST00000113134.2 ENSMUST00000113134.3 ENSMUST00000113134.4 ENSMUST00000113134.5 ENSMUST00000113134.6 ENSMUST00000113134.7 NM_145079 P70692 Q62580 Q64435 Q6XL47 UD16_MOUSE Ugt1 Ugt1a6 Ugt1a7 uc007byf.1 uc007byf.2 uc007byf.3 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4- nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4- hydroxybiphenyl, androgens and estrogens are not substrates. 2- hydroxybiphenyl is an excellent substrate. Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21033; Evidence=; Microsome. Endoplasmic reticulum membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.; Name=1; IsoId=Q64435-1; Sequence=Displayed; Expressed in liver, kidney and at very low levels in colon. By dioxin. Belongs to the UDP-glycosyltransferase family. mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum membrane glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups glucuronate metabolic process enzyme binding macromolecular complex protein homodimerization activity intracellular membrane-bounded organelle macromolecular complex binding protein heterodimerization activity flavonoid glucuronidation xenobiotic glucuronidation uc007byf.1 uc007byf.2 uc007byf.3 
ENSMUST00000113138.8 Ugt1a6b ENSMUST00000113138.8 UDP glucuronosyltransferase 1 family, polypeptide A6B (from RefSeq NM_201410.3) ENSMUST00000113138.1 ENSMUST00000113138.2 ENSMUST00000113138.3 ENSMUST00000113138.4 ENSMUST00000113138.5 ENSMUST00000113138.6 ENSMUST00000113138.7 K9J7B2 K9J7B2_MOUSE NM_201410 Ugt1a6b uc007byd.1 uc007byd.2 uc007byd.3 uc007byd.4 Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; Endoplasmic reticulum membrane ; Single-pass membrane protein Membrane ; Single- pass membrane protein Belongs to the UDP-glycosyltransferase family. endoplasmic reticulum glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups enzyme binding macromolecular complex protein homodimerization activity intracellular membrane-bounded organelle macromolecular complex binding protein heterodimerization activity flavonoid glucuronidation xenobiotic glucuronidation uc007byd.1 uc007byd.2 uc007byd.3 uc007byd.4 
ENSMUST00000113139.2 Ugt1a8 ENSMUST00000113139.2 UDP glucuronosyltransferase 1 family, polypeptide A8 (from RefSeq NM_001378375.1) D3Z748 D3Z748_MOUSE ENSMUST00000113139.1 NM_001378375 Ugt1a8 uc287kfc.1 uc287kfc.2 Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; Endoplasmic reticulum membrane ; Single-pass membrane protein Membrane ; Single- pass membrane protein Belongs to the UDP-glycosyltransferase family. glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups flavonoid glucuronidation xenobiotic glucuronidation uc287kfc.1 uc287kfc.2 
ENSMUST00000113142.10 Ugt1a10 ENSMUST00000113142.10 UDP glycosyltransferase 1 family, polypeptide A10 (from RefSeq NM_201641.2) E9PXN7 E9PXN7_MOUSE ENSMUST00000113142.1 ENSMUST00000113142.2 ENSMUST00000113142.3 ENSMUST00000113142.4 ENSMUST00000113142.5 ENSMUST00000113142.6 ENSMUST00000113142.7 ENSMUST00000113142.8 ENSMUST00000113142.9 NM_201641 Ugt1a10 uc007bya.1 uc007bya.2 uc007bya.3 Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; Endoplasmic reticulum membrane ; Single-pass membrane protein Membrane ; Single- pass membrane protein Belongs to the UDP-glycosyltransferase family. enzyme inhibitor activity protein kinase C binding steroid binding fatty acid binding endoplasmic reticulum drug binding glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups enzyme binding protein homodimerization activity negative regulation of catalytic activity protein heterodimerization activity flavonoid glucuronidation xenobiotic glucuronidation uc007bya.1 uc007bya.2 uc007bya.3 
ENSMUST00000113146.9 Mtmr14 ENSMUST00000113146.9 myotubularin related protein 14, transcript variant 5 (from RefSeq NR_155432.1) ENSMUST00000113146.1 ENSMUST00000113146.2 ENSMUST00000113146.3 ENSMUST00000113146.4 ENSMUST00000113146.5 ENSMUST00000113146.6 ENSMUST00000113146.7 ENSMUST00000113146.8 MTMRE_MOUSE NR_155432 Q8VEL2 uc009dex.1 uc009dex.2 uc009dex.3 Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Cytoplasm. Note=Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus (By similarity). In C2C12 cell line, increased expression during myotube formation and differentiation in culture. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. Sequence=AAH18294.1; Type=Erroneous initiation; Evidence=; ruffle phosphatidylinositol-3-phosphatase activity protein tyrosine phosphatase activity cytoplasm dephosphorylation hydrolase activity peptidyl-tyrosine dephosphorylation perinuclear region of cytoplasm uc009dex.1 uc009dex.2 uc009dex.3 
ENSMUST00000113147.8 Gprasp1 ENSMUST00000113147.8 Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2. (from UniProt Q5U4C1) A2AGB6 BC085157 ENSMUST00000113147.1 ENSMUST00000113147.2 ENSMUST00000113147.3 ENSMUST00000113147.4 ENSMUST00000113147.5 ENSMUST00000113147.6 ENSMUST00000113147.7 GASP1_MOUSE Kiaa0443 Q5U4C1 Q8BKR8 Q8BUN4 Q8BYK9 Q8CHF4 Q8R095 uc009uhq.1 uc009uhq.2 uc009uhq.3 Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2. Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4 as well as D2 dopamine receptor/DRD2. Interacts with PER1 (By similarity). Interacts with BECN2; the interaction is direct. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5U4C1-1; Sequence=Displayed; Name=2; IsoId=Q5U4C1-2; Sequence=VSP_019080; Expressed in the brain, with higher expression in the hippocampus, hypothalamus and olfactory bulb. Belongs to the GPRASP family. Sequence=BAC41425.1; Type=Erroneous initiation; Evidence=; nucleus cytoplasm cytosol endosome to lysosome transport G-protein coupled receptor catabolic process uc009uhq.1 uc009uhq.2 uc009uhq.3 
ENSMUST00000113149.8 Mrap2 ENSMUST00000113149.8 melanocortin 2 receptor accessory protein 2, transcript variant 4 (from RefSeq NM_001421369.1) D3YVA7 D3YZ75 D3Z1Q2 D3Z746 ENSMUST00000113149.1 ENSMUST00000113149.2 ENSMUST00000113149.3 ENSMUST00000113149.4 ENSMUST00000113149.5 ENSMUST00000113149.6 ENSMUST00000113149.7 MRAP2_MOUSE NM_001421369 uc292jjs.1 uc292jjs.2 Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand- sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo. Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP. Interacts with MC1R, MC2R, MC3R and MC5R (By similarity). Interacts with MC4R. D3Z1Q2; Q8JZL2: Mchr1; NbExp=4; IntAct=EBI-44454554, EBI-44454520; Cell membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. Predominantly expressed in the brain, mainly in the pons and cerebellum but also in regions involved in energy homeostasis, such as the hypothalamus and brainstem. Obesity. Mice are normal at birth, with normal weight gain and post-weaning food intake during early life, although young males trend toward greater weight and food intake with advancing age. Mice of both genders gradually become extremely obese on a diet of regular chow ad libitum. Belongs to the MRAP family. endoplasmic reticulum endoplasmic reticulum membrane plasma membrane energy reserve metabolic process feeding behavior membrane integral component of membrane receptor regulator activity corticotropin hormone receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding type 5 melanocortin receptor binding identical protein binding type 1 melanocortin receptor binding protein localization to plasma membrane energy homeostasis negative regulation of protein localization to plasma membrane uc292jjs.1 uc292jjs.2 
ENSMUST00000113158.8 Zbtb34 ENSMUST00000113158.8 zinc finger and BTB domain containing 34, transcript variant 2 (from RefSeq NM_001276332.2) A2ATY4 A2ATY4_MOUSE ENSMUST00000113158.1 ENSMUST00000113158.2 ENSMUST00000113158.3 ENSMUST00000113158.4 ENSMUST00000113158.5 ENSMUST00000113158.6 ENSMUST00000113158.7 NM_001276332 Zbtb34 uc008jhu.1 uc008jhu.2 negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus nucleoplasm biological_process uc008jhu.1 uc008jhu.2 
ENSMUST00000113159.9 Pramex1 ENSMUST00000113159.9 PRAME like, X-linked 1 (from RefSeq NM_029459.3) ENSMUST00000113159.1 ENSMUST00000113159.2 ENSMUST00000113159.3 ENSMUST00000113159.4 ENSMUST00000113159.5 ENSMUST00000113159.6 ENSMUST00000113159.7 ENSMUST00000113159.8 F7ADI6 F7ADI6_MOUSE NM_029459 Pramex1 uc292qpb.1 uc292qpb.2 uc292qpb.3 uc292qpb.1 uc292qpb.2 uc292qpb.3 
ENSMUST00000113163.8 Nxf7 ENSMUST00000113163.8 nuclear RNA export factor 7, transcript variant 1 (from RefSeq NM_130888.2) ENSMUST00000113163.1 ENSMUST00000113163.2 ENSMUST00000113163.3 ENSMUST00000113163.4 ENSMUST00000113163.5 ENSMUST00000113163.6 ENSMUST00000113163.7 NM_130888 NXF7 Nxf7 Q80SZ6 Q80SZ6_MOUSE uc009uhh.1 uc009uhh.2 uc009uhh.3 Cytoplasm Nucleus, nucleoplasm Belongs to the NXF family. nucleic acid binding RNA binding mRNA binding nucleus cytoplasm mRNA export from nucleus poly(A)+ mRNA export from nucleus mRNA transport uc009uhh.1 uc009uhh.2 uc009uhh.3 
ENSMUST00000113172.8 Pramel3b ENSMUST00000113172.8 PRAME like 3B (from RefSeq NM_001242937.1) ENSMUST00000113172.1 ENSMUST00000113172.2 ENSMUST00000113172.3 ENSMUST00000113172.4 ENSMUST00000113172.5 ENSMUST00000113172.6 ENSMUST00000113172.7 J3QP96 J3QP96_MOUSE NM_001242937 Pramel3b Pramel3c uc012hoq.1 uc012hoq.2 uc012hoq.3 uc012hoq.4 uc012hoq.5 uc012hoq.6 uc012hoq.1 uc012hoq.2 uc012hoq.3 uc012hoq.4 uc012hoq.5 uc012hoq.6 
ENSMUST00000113179.9 Afm ENSMUST00000113179.9 afamin (from RefSeq NM_145146.3) AFAM_MOUSE ENSMUST00000113179.1 ENSMUST00000113179.2 ENSMUST00000113179.3 ENSMUST00000113179.4 ENSMUST00000113179.5 ENSMUST00000113179.6 ENSMUST00000113179.7 ENSMUST00000113179.8 NM_145146 O89020 Q3UNV0 Q497E6 Q8R0J9 uc008ybc.1 uc008ybc.2 uc008ybc.3 Functions as a carrier for hydrophobic molecules in body fluids. Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B. Binds vitamin E. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the transport of vitamin E across the blood-brain barrier. Forms a 1:1 complex with Wnt family members; interacts with WNT1, WNT2B, WNT3, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B (By similarity). Interacts with WNT3A (PubMed:26902720). Secreted Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O89020-1; Sequence=Displayed; Name=2; IsoId=O89020-2; Sequence=VSP_023387, VSP_023388; Name=3; IsoId=O89020-3; Sequence=VSP_023389; Detected in brain, especially on brain capillaries (at protein level). Expressed in isolated brain capillaries. The second albumin domain forms a deep binding pocket that contains palmitoleic acid (in vitro). Palmitoleic acid is most likely not the physiological ligand. Instead, this pocket may accomodate the covalently bound lipid moiety of Wnt family members. N-glycosylated; more than 90% of the glycans are sialylated. Belongs to the ALB/AFP/VDB family. Sequence=AAH26681.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence=; fatty acid binding extracellular region extracellular space cytoplasm zinc ion binding vitamin E binding protein transport protein stabilization vitamin transport protein transport within extracellular region uc008ybc.1 uc008ybc.2 uc008ybc.3 
ENSMUST00000113182.8 Rad18 ENSMUST00000113182.8 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; (from UniProt D3Z733) AK030043 D3Z733 D3Z733_MOUSE ENSMUST00000113182.1 ENSMUST00000113182.2 ENSMUST00000113182.3 ENSMUST00000113182.4 ENSMUST00000113182.5 ENSMUST00000113182.6 ENSMUST00000113182.7 Rad18 uc291hrf.1 uc291hrf.2 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Nucleus Belongs to the RAD18 family. DNA binding single-stranded DNA binding DNA repair postreplication repair protein monoubiquitination ubiquitin protein ligase activity uc291hrf.1 uc291hrf.2 
ENSMUST00000113183.2 Pramel3d ENSMUST00000113183.2 PRAME like 3D (from RefSeq NM_001099321.3) AV320801 ENSMUST00000113183.1 Gm15023 L7MUB4 NM_001099321 OTTMUSG00000018782 Pramel3d Q1RLK3 Q1RLK3_MOUSE uc009uhb.1 uc009uhb.2 uc009uhb.3 uc009uhb.4 molecular_function cytoplasm biological_process uc009uhb.1 uc009uhb.2 uc009uhb.3 uc009uhb.4 
ENSMUST00000113200.8 Lrsam1 ENSMUST00000113200.8 leucine rich repeat and sterile alpha motif containing 1, transcript variant 24 (from RefSeq NR_176932.1) ENSMUST00000113200.1 ENSMUST00000113200.2 ENSMUST00000113200.3 ENSMUST00000113200.4 ENSMUST00000113200.5 ENSMUST00000113200.6 ENSMUST00000113200.7 LRSM1_MOUSE Lrsam1 NR_176932 Q80ZI6 uc289vga.1 uc289vga.2 E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (viral proteins) cargos (By similarity). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (By similarity). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with TSG101. Interacts with PHF23. Interacts with FUS. Cytoplasm Note=Displays a punctuate distribution and localizes to a submembranal ring (PubMed:15256501). Localizes to intracellular bacterial pathogens (By similarity). Widely expressed. The coiled coil domains interact with the SB domain of TSG101. The PTAP motifs mediate the binding to UEV domains. The LRR domain is necessary and sufficient for localization to bacterial targets. The RING domain is required for ubiquitination. Ubiquitination promoted by PHF23 leads to proteasomal degradation. protein polyubiquitination ubiquitin-protein transferase activity cytoplasm cytosol autophagy protein transport membrane protein ubiquitination transferase activity protein catabolic process negative regulation of endocytosis viral budding metal ion binding protein autoubiquitination ubiquitin protein ligase activity ubiquitin-dependent endocytosis positive regulation of xenophagy positive regulation of autophagosome assembly uc289vga.1 uc289vga.2 
ENSMUST00000113211.8 Rpl36a ENSMUST00000113211.8 ribosomal protein L36A (from RefSeq NM_019865.5) ENSMUST00000113211.1 ENSMUST00000113211.2 ENSMUST00000113211.3 ENSMUST00000113211.4 ENSMUST00000113211.5 ENSMUST00000113211.6 ENSMUST00000113211.7 NM_019865 Q5M9P1 Q5M9P1_MOUSE Rpl36a uc009ugf.1 uc009ugf.2 uc009ugf.3 uc009ugf.4 Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL42 family. structural constituent of ribosome endoplasmic reticulum cytosol ribosome plasma membrane translation cytosolic large ribosomal subunit uc009ugf.1 uc009ugf.2 uc009ugf.3 uc009ugf.4 
ENSMUST00000113212.4 Kcnj13 ENSMUST00000113212.4 potassium inwardly-rectifying channel, subfamily J, member 13 (from RefSeq NM_001110227.2) ENSMUST00000113212.1 ENSMUST00000113212.2 ENSMUST00000113212.3 KCJ13_MOUSE Kcnj13 NM_001110227 P86046 uc007bwu.1 uc007bwu.2 uc007bwu.3 uc007bwu.4 uc007bwu.5 Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium (By similarity). Membrane ; Multi-pass membrane protein Phosphorylation at Ser-287 by PKA increases ionic currents. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ13 subfamily. inward rectifier potassium channel activity voltage-gated ion channel activity ion transport potassium ion transport membrane integral component of membrane regulation of ion transmembrane transport potassium ion import across plasma membrane uc007bwu.1 uc007bwu.2 uc007bwu.3 uc007bwu.4 uc007bwu.5 
ENSMUST00000113215.10 Sh3bgrl2 ENSMUST00000113215.10 SH3 domain binding glutamic acid-rich protein like 2 (from RefSeq NM_172507.5) ENSMUST00000113215.1 ENSMUST00000113215.2 ENSMUST00000113215.3 ENSMUST00000113215.4 ENSMUST00000113215.5 ENSMUST00000113215.6 ENSMUST00000113215.7 ENSMUST00000113215.8 ENSMUST00000113215.9 NM_172507 Q3TV64 Q8BG73 SH3L2_MOUSE uc009qwl.1 uc009qwl.2 uc009qwl.3 uc009qwl.4 Nucleus Belongs to the SH3BGR family. protein binding nucleus nucleoplasm biological_process SH3 domain binding nuclear membrane uc009qwl.1 uc009qwl.2 uc009qwl.3 uc009qwl.4 
ENSMUST00000113223.3 Taf7l ENSMUST00000113223.3 Nucleus (from UniProt B1AV36) B1AV36 B1AV36_MOUSE BC106854 ENSMUST00000113223.1 ENSMUST00000113223.2 Taf7l uc292qmw.1 uc292qmw.2 Nucleus Belongs to the TAF7 family. transcription factor TFIID complex transcription initiation from RNA polymerase II promoter uc292qmw.1 uc292qmw.2 
ENSMUST00000113235.8 Eif4e2 ENSMUST00000113235.8 eukaryotic translation initiation factor 4E member 2, transcript variant 4 (from RefSeq NM_001347083.1) D3Z729 D3Z729_MOUSE ENSMUST00000113235.1 ENSMUST00000113235.2 ENSMUST00000113235.3 ENSMUST00000113235.4 ENSMUST00000113235.5 ENSMUST00000113235.6 ENSMUST00000113235.7 Eif4e2 NM_001347083 uc057kfx.1 uc057kfx.2 uc057kfx.3 Belongs to the eukaryotic initiation factor 4E family. RNA binding translation initiation factor activity cytoplasm translation translational initiation uc057kfx.1 uc057kfx.2 uc057kfx.3 
ENSMUST00000113239.10 Crbn ENSMUST00000113239.10 cereblon, transcript variant 2 (from RefSeq NM_175357.3) CRBN_MOUSE ENSMUST00000113239.1 ENSMUST00000113239.2 ENSMUST00000113239.3 ENSMUST00000113239.4 ENSMUST00000113239.5 ENSMUST00000113239.6 ENSMUST00000113239.7 ENSMUST00000113239.8 ENSMUST00000113239.9 NM_175357 Q3TVC2 Q5RJV6 Q6IS49 Q80XJ1 Q8BP45 Q8C6B7 Q8C7D2 Q9JKR4 uc009ddb.1 uc009ddb.2 uc009ddb.3 uc009ddb.4 uc009ddb.5 This gene encodes a protein with a Lon protease domain, a 'regulators of G protein-signaling' (RGS)-like domain and a leucine zipper. It has been proposed to regulate the assembly and surface expression of large-conductance calcium-activated potassium channels in brain and to bind thalidomide. In humans mutation in this gene causes autosomal recessive nonsyndromic cognitive disability. In mouse deficiency of this gene serves as a model to study the molecular mechanisms governing learning and memory as they relate to intellectual disability. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 or ILF2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). Maintains presynaptic glutamate release and consequently, cognitive functions such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons (PubMed:29530986). Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (By similarity). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (PubMed:29530986). Plays a negative role in TLR4 signaling by interacting with TRAF6 and ECSIT, leading to inhibition of ECSIT ubiquitination, an important step of the signaling (By similarity). Protein modification; protein ubiquitination. Component of a DCX (DDB1-CUL4-X-box) protein ligase complex, at least composed of CRBN, CUL4A, DDB1 and RBX1. Interacts directly with DDB1 (By similarity). Interacts with KCNT1 (By similarity). Interacts with ILF2 (By similarity). Interacts with TRAF6 and ECSIT (By similarity). Cytoplasm Nucleus Membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C7D2-1; Sequence=Displayed; Name=2; IsoId=Q8C7D2-2; Sequence=VSP_015210; Name=3; IsoId=Q8C7D2-3; Sequence=VSP_039063; Highly expressed in brain. In brain, expression is abundant in the cerebellum, with less expression in the neocortical, hippocampus and striatum in adult. Neocortical expression increases from embryonic stages to adulthood. The CULT domain binds thalidomide and related drugs. Thalidomide binding leads to a change in substrate specificity of the human DCX (DDB1-CUL4-X-box) E3 protein ligase complex, while no such change is observed in rodents. Ubiquitinated, ubiquitination is mediated by its own DCX protein ligase complex. No obvious phenotype, however mice display increased BK channel activity and a subsequent decrease in synaptic transmission and presynaptic release probability in excitatory synapses (PubMed:29530986). Mice also display cognitive behavioral defects such as abnormal passive avoidance, hyperanxious behavior and decreased preference for new objects (PubMed:29530986). Treatment with the BK blocker paxilline rescues all synaptic and behavioral abnormalities except for hyperanxiety (PubMed:29530986). Brain and synaptic morphology is normal and long-term synaptic plasticity is not affected (PubMed:29530986). Conditional knockout in the forebrain results in no obvious phenotype, however mice display a deficit in contextual fear learning whereas anxiety-like behavior is unaffected (PubMed:21995942). Belongs to the CRBN family. Sequence=AAF35895.1; Type=Frameshift; Evidence=; nucleus nucleolus cytoplasm membrane protein ubiquitination Cul4A-RING E3 ubiquitin ligase complex negative regulation of protein homooligomerization negative regulation of ion transmembrane transport proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding positive regulation of protein homodimerization activity uc009ddb.1 uc009ddb.2 uc009ddb.3 uc009ddb.4 uc009ddb.5 
ENSMUST00000113242.5 Sh2d3c ENSMUST00000113242.5 SH2 domain containing 3C, transcript variant 9 (from RefSeq NM_001412523.1) A2AK84 Chat ENSMUST00000113242.1 ENSMUST00000113242.2 ENSMUST00000113242.3 ENSMUST00000113242.4 NM_001412523 Q9JME1 Q9QZS8 SH2D3_MOUSE Shep1 uc008jgr.1 uc008jgr.2 uc008jgr.3 uc008jgr.4 Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:20505138, PubMed:20881139, PubMed:20956287). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (By similarity). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (PubMed:20505138, PubMed:20956287). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (PubMed:20505138). Plays a role in CXCL13-induced chemotaxis of B-cells (PubMed:20505138, PubMed:20956287). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (PubMed:20881139). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (PubMed:20881139). [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (PubMed:17174122). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (PubMed:17174122). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (PubMed:17174122). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (PubMed:12486027). [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (By similarity). Within the complex, interacts with CRK and (via C- terminus) with BCAR1/CAS (via C-terminus) (PubMed:10692442, PubMed:17174122). Interacts with NEDD9/HEF1 (PubMed:20956287). Interacts with EPHB2 (PubMed:10542222). [Isoform 1]: Interacts with NEDD9/HEF1 (PubMed:10692442, PubMed:17174122). Interacts with BCAR1/CAS (PubMed:10692442). Interacts with PTK2B (PubMed:12486027). [Isoform 2]: Interacts (via C-terminus) with BCAR1/CAS (via C- terminus) (PubMed:10692442). Interacts with IGF1 (PubMed:20881139). Q9QZS8; O35177: Nedd9; NbExp=2; IntAct=EBI-7964037, EBI-2642891; Cytoplasm ll membrane ; Peripheral membrane protein Cell projection, axon Cell projection, ruffle membrane Note=Associated with the membrane when EGF-stimulated (PubMed:10692442). Expressed at the cortical actin ring in B cells (PubMed:20956287). [Isoform 1]: Cell membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Chat-H; IsoId=Q9QZS8-1; Sequence=Displayed; Name=2; Synonyms=Chat; IsoId=Q9QZS8-2; Sequence=VSP_017709; Expressed in the olfactory bulb and olfactory sensory neurons (at protein level) (PubMed:20881139). Expressed in B cells (at protein level) (PubMed:20505138, PubMed:20956287). Expressed in T lymphocytes (PubMed:17174122). [Isoform 1]: Expressed in hematopoietic cells from spleen, lymph node and thymus (at protein level) (PubMed:10542222, PubMed:10692442, PubMed:12486027). Expressed weakly in the lung (at protein level) (PubMed:10692442). [Isoform 2]: Expressed in the brain, lung, kidney, and weakly expressed in the liver and lung (at protein level). Expressed in the developing OSNs at dpc 13.5 and 14.5 with reduced expression at dpc 16.5. The C-terminal Cdc25-homology/Ras-GEF domain adopts a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is required for interaction with BCAR1. [Isoform 1]: Phosphorylated by MAPK/ERK upon T-cell receptor stimulation in T-cells. In one study knockout mice are viable and born at the expected Mendelian rate (PubMed:20505138). In another study the majority of knockout mice die after birth, those that survive show severe lamination defects and loss of cellular organization in their olfactory bulb, with a reduction in gonadotropin-releasing hormone in the preoptic region of the hypothalamus (PubMed:20881139). Mice that die at birth are morphologically normal apart from a marked reduction in the size of the olfactory bulb, which exhibits abnormal cellular organization in the outer layers and a lack of innervation of OSNs (PubMed:20881139). At dpc 16.5 OSNs fail to extend into the marginal zone of the forming olfactory bulb from the basement membrane, and show a reduction in tyrosine phosphorylated BCAR1 (PubMed:20881139). Decrease in B cells in the splenic marginal zone (PubMed:20505138, PubMed:20956287). It is unclear if the knockout of Sh2d3c causes lethality (PubMed:20505138, PubMed:20881139). One report in genetic knockout mice suggests it is viable (PubMed:20505138). Another report in the same strain but a different genetic knockout model suggests lethality (PubMed:20881139). transmembrane receptor protein tyrosine kinase adaptor activity guanyl-nucleotide exchange factor activity protein binding cytoplasm signal transduction transmembrane receptor protein tyrosine kinase signaling pathway small GTPase mediated signal transduction membrane positive regulation of peptidyl-serine phosphorylation uc008jgr.1 uc008jgr.2 uc008jgr.3 uc008jgr.4 
ENSMUST00000113245.9 Irak1bp1 ENSMUST00000113245.9 interleukin-1 receptor-associated kinase 1 binding protein 1, transcript variant 1 (from RefSeq NM_022986.4) Aip70 ENSMUST00000113245.1 ENSMUST00000113245.2 ENSMUST00000113245.3 ENSMUST00000113245.4 ENSMUST00000113245.5 ENSMUST00000113245.6 ENSMUST00000113245.7 ENSMUST00000113245.8 IKBP1_MOUSE NM_022986 Q8BT82 Q8C645 Q9CRM0 Q9CV21 Q9CX27 Q9ESJ7 Q9JK12 Simpl uc009qvs.1 uc009qvs.2 uc009qvs.3 uc009qvs.4 Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity. Interacts with IRAK1 and RELA. Interacts with HSPA8 and HSPA1. May interact with Listeria monocytogenes actA. Cytoplasm Nucleus Expressed in testis, brain, kidney, liver and heart. Expression peaks at 10 dpc. The disordered region interacts with HSPA1 and HSPA8. Phosphorylation at Ser-55, Ser-61 and/or Ser-63 is required for full activity. Phosphorylated on at least one of Ser-234, Thr-236, Ser- 241 and Thr-246 upon TNF-alpha activation, which favors nuclear translocation. Belongs to the IRAK1BP1 family. Sequence=BAB32019.1; Type=Erroneous initiation; Evidence=; protein binding nucleus cytoplasm immune response I-kappaB kinase/NF-kappaB signaling uc009qvs.1 uc009qvs.2 uc009qvs.3 uc009qvs.4 
ENSMUST00000113250.10 Impg1 ENSMUST00000113250.10 interphotoreceptor matrix proteoglycan 1 (from RefSeq NM_022016.3) ENSMUST00000113250.1 ENSMUST00000113250.2 ENSMUST00000113250.3 ENSMUST00000113250.4 ENSMUST00000113250.5 ENSMUST00000113250.6 ENSMUST00000113250.7 ENSMUST00000113250.8 ENSMUST00000113250.9 IMPG1_MOUSE Impg1 NM_022016 Q8R1W8 Q9CTP8 Q9ES62 Q9ET31 Spacr uc009qvi.1 uc009qvi.2 uc009qvi.3 uc009qvi.4 Chondroitin sulfate-, heparin- and hyaluronan-binding protein (By similarity). May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (By similarity). Cell projection, cilium, photoreceptor outer segment Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix Photoreceptor inner segment Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q8R1W8-1; Sequence=Displayed; Name=2 ; IsoId=Q8R1W8-2; Sequence=VSP_052171; Name=3 ; IsoId=Q8R1W8-3; Sequence=VSP_052172; Abundantly expressed in the retina (at protein level). Highly glycosylated (N- and O-linked carbohydrates and sialic acid). extracellular region visual perception uc009qvi.1 uc009qvi.2 uc009qvi.3 uc009qvi.4 
ENSMUST00000113264.9 Cntn4 ENSMUST00000113264.9 contactin 4, transcript variant 35 (from RefSeq NR_177651.1) CNTN4_MOUSE ENSMUST00000113264.1 ENSMUST00000113264.2 ENSMUST00000113264.3 ENSMUST00000113264.4 ENSMUST00000113264.5 ENSMUST00000113264.6 ENSMUST00000113264.7 ENSMUST00000113264.8 Kiaa3024 NR_177651 Q14BL8 Q69Z26 Q8BRT6 Q8CBD3 uc009dcv.1 uc009dcv.2 uc009dcv.3 Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis. Interacts with PTPRG. Cell membrane; Lipid-anchor, GPI-anchor. Secreted Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q69Z26-1; Sequence=Displayed; Name=2; Synonyms=BIG-2A; IsoId=Q69Z26-2; Sequence=VSP_011965, VSP_011966; Name=3; IsoId=Q69Z26-3; Sequence=VSP_011963, VSP_011964; Expressed in the region of developing olfactory neurons. Isoform 2 is expressed in mature sensory cells of the vomeronasal neuroepithelium and at lower level in olfactory neuroepithelium. Expressed from 14 dpc at a time when developing axons reach the olfactory bulb. Belongs to the immunoglobulin superfamily. Contactin family. extracellular region plasma membrane cell adhesion nervous system development axon guidance brain development membrane neuron projection development anchored component of membrane negative regulation of neuron differentiation uc009dcv.1 uc009dcv.2 uc009dcv.3 
ENSMUST00000113270.3 Alpi ENSMUST00000113270.3 alkaline phosphatase, intestinal (from RefSeq NM_001081082.2) Alpi ENSMUST00000113270.1 ENSMUST00000113270.2 F8VPQ6 F8VPQ6_MOUSE NM_001081082 uc007bwa.1 uc007bwa.2 uc007bwa.3 Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.1; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions. ; Homodimer. Cell membrane ; Lipid-anchor, GPI-anchor Membrane ; Lipid-anchor, GPI-anchor Belongs to the alkaline phosphatase family. magnesium ion binding catalytic activity alkaline phosphatase activity plasma membrane phosphorus metabolic process zinc ion binding external side of plasma membrane cell surface dephosphorylation hydrolase activity phosphatase activity protein homodimerization activity cellular response to BMP stimulus uc007bwa.1 uc007bwa.2 uc007bwa.3 
ENSMUST00000113278.9 Ak1 ENSMUST00000113278.9 adenylate kinase 1, transcript variant 4 (from RefSeq NM_001198792.1) A2AK80 ENSMUST00000113278.1 ENSMUST00000113278.2 ENSMUST00000113278.3 ENSMUST00000113278.4 ENSMUST00000113278.5 ENSMUST00000113278.6 ENSMUST00000113278.7 ENSMUST00000113278.8 KAD1_MOUSE NM_001198792 Q542C5 Q9R0Y4 Q9R0Y5 uc008jgh.1 uc008jgh.2 uc008jgh.3 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP (By similarity). Exhibits nucleoside diphosphate kinase activity, catalyzing the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and dTTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor (By similarity). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (By similarity). May provide a mechanism to buffer the adenylate energy charge for sperm motility (PubMed:16790685). Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3; Evidence=; Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence= Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Reaction=a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'- diphosphate + ADP; Xref=Rhea:RHEA:13749, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.10; Evidence=; Reaction=ATP + GDP = ADP + GTP; Xref=Rhea:RHEA:27686, ChEBI:CHEBI:30616, ChEBI:CHEBI:37565, ChEBI:CHEBI:58189, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Reaction=ATP + UDP = ADP + UTP; Xref=Rhea:RHEA:25098, ChEBI:CHEBI:30616, ChEBI:CHEBI:46398, ChEBI:CHEBI:58223, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Reaction=ATP + dGDP = ADP + dGTP; Xref=Rhea:RHEA:27690, ChEBI:CHEBI:30616, ChEBI:CHEBI:58595, ChEBI:CHEBI:61429, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Reaction=ATP + dTDP = ADP + dTTP; Xref=Rhea:RHEA:27682, ChEBI:CHEBI:30616, ChEBI:CHEBI:37568, ChEBI:CHEBI:58369, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Reaction=ADP + thiamine diphosphate = AMP + thiamine triphosphate; Xref=Rhea:RHEA:69180, ChEBI:CHEBI:58937, ChEBI:CHEBI:58938, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Monomer. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Ak1a; IsoId=Q9R0Y5-1; Sequence=Displayed; Name=2; Synonyms=Ak1b; IsoId=Q9R0Y5-2; Sequence=VSP_024843; Up-regulated during late spermiogenesis, when the flagellum is being assembled. Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Belongs to the adenylate kinase family. AK1 subfamily. Sequence=CAM16612.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding outer dense fiber adenylate kinase activity nucleoside diphosphate kinase activity ATP binding cytoplasm cytosol plasma membrane nucleobase-containing compound metabolic process nucleoside diphosphate phosphorylation ADP biosynthetic process cell cycle arrest nucleoside triphosphate biosynthetic process positive regulation of glucose transport kinase activity phosphorylation transferase activity nucleobase-containing compound kinase activity sarcomere sperm flagellum neuron projection AMP metabolic process ATP metabolic process inosine biosynthetic process nucleoside monophosphate phosphorylation perinuclear region of cytoplasm phosphotransferase activity, phosphate group as acceptor uc008jgh.1 uc008jgh.2 uc008jgh.3 
ENSMUST00000113290.8 St6galnac6 ENSMUST00000113290.8 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6, transcript variant 5 (from RefSeq NM_001289548.1) E9PU98 E9PUI0 E9PUI0_MOUSE ENSMUST00000113290.1 ENSMUST00000113290.2 ENSMUST00000113290.3 ENSMUST00000113290.4 ENSMUST00000113290.5 ENSMUST00000113290.6 ENSMUST00000113290.7 NM_001289548 St6galnac6 uc008jgc.1 uc008jgc.2 uc008jgc.3 uc008jgc.4 Reaction=a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41968, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568, ChEBI:CHEBI:78569; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41969; Evidence=; Membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 29 family. Golgi apparatus protein glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups sialylation uc008jgc.1 uc008jgc.2 uc008jgc.3 uc008jgc.4 
ENSMUST00000113296.8 Frs3 ENSMUST00000113296.8 fibroblast growth factor receptor substrate 3 (from RefSeq NM_144939.3) ENSMUST00000113296.1 ENSMUST00000113296.2 ENSMUST00000113296.3 ENSMUST00000113296.4 ENSMUST00000113296.5 ENSMUST00000113296.6 ENSMUST00000113296.7 FRS3_MOUSE Frs2b NM_144939 Q91WJ0 uc008cvz.1 uc008cvz.2 uc008cvz.3 Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2. Binds NGFR, GRB2, PTPN11 and ERK2 (By similarity). Binds FGFR1 and NTRK1. Membrane; Lipid-anchor. Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB. Phosphorylated by ULK2 in vitro. fibroblast growth factor receptor binding fibroblast growth factor receptor signaling pathway membrane identical protein binding uc008cvz.1 uc008cvz.2 uc008cvz.3 
ENSMUST00000113298.9 Slc22a29 ENSMUST00000113298.9 solute carrier family 22. member 29, transcript variant 1 (from RefSeq NM_172776.3) ENSMUST00000113298.1 ENSMUST00000113298.2 ENSMUST00000113298.3 ENSMUST00000113298.4 ENSMUST00000113298.5 ENSMUST00000113298.6 ENSMUST00000113298.7 ENSMUST00000113298.8 NM_172776 Q8BWG6 Q8BWG6_MOUSE Slc22a29 uc008glu.1 uc008glu.2 uc008glu.3 Membrane ; Multi- pass membrane protein organic anion transport membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008glu.1 uc008glu.2 uc008glu.3 
ENSMUST00000113300.8 Prickle4 ENSMUST00000113300.8 prickle planar cell polarity protein 4 (from RefSeq NM_001290337.1) D3Z6Q6 D3Z6Q6_MOUSE ENSMUST00000113300.1 ENSMUST00000113300.2 ENSMUST00000113300.3 ENSMUST00000113300.4 ENSMUST00000113300.5 ENSMUST00000113300.6 ENSMUST00000113300.7 Gm21981 NM_001290337 Prickle4 uc289lqw.1 uc289lqw.2 stress fiber actin binding cell-cell adherens junction heart development zinc ion binding Z disc actin cytoskeleton organization filamentous actin metal ion binding muscle alpha-actinin binding muscle structure development uc289lqw.1 uc289lqw.2 
ENSMUST00000113302.10 Tomm6 ENSMUST00000113302.10 translocase of outer mitochondrial membrane 6, transcript variant 2 (from RefSeq NM_025365.3) ENSMUST00000113302.1 ENSMUST00000113302.2 ENSMUST00000113302.3 ENSMUST00000113302.4 ENSMUST00000113302.5 ENSMUST00000113302.6 ENSMUST00000113302.7 ENSMUST00000113302.8 ENSMUST00000113302.9 NM_025365 Obtp Q9CQN3 TOM6_MOUSE Tom6 uc008cvx.1 uc008cvx.2 uc008cvx.3 uc008cvx.4 Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Mitochondrion outer membrane Belongs to the Tom6 family. molecular_function mitochondrion mitochondrial outer membrane mitochondrial outer membrane translocase complex protein transport membrane uc008cvx.1 uc008cvx.2 uc008cvx.3 uc008cvx.4 
ENSMUST00000113304.2 Srpx2 ENSMUST00000113304.2 sushi-repeat-containing protein, X-linked 2, transcript variant 2 (from RefSeq NM_001083895.3) B1AVI6 ENSMUST00000113304.1 NM_001083895 Q3UVU0 Q8K1F8 Q8K4W6 Q8R054 SRPX2_MOUSE uc009ufd.1 uc009ufd.2 uc009ufd.3 uc009ufd.4 uc009ufd.5 Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations. Forms homooligomers. Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF (By similarity). Secreted Cytoplasm Cell surface Synapse Expressed in angiogenic endothelial cells (at protein level). Contains chondroitin sulfate chains. Sequence=AAH28307.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE23179.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; angiogenesis receptor binding extracellular matrix structural constituent extracellular region extracellular space cytoplasm cell adhesion cell surface cell junction hepatocyte growth factor binding regulation of phosphorylation identical protein binding synapse cell motility positive regulation of synapse assembly excitatory synapse vocalization behavior positive regulation of cell migration involved in sprouting angiogenesis synaptic membrane cell-cell adhesion uc009ufd.1 uc009ufd.2 uc009ufd.3 uc009ufd.4 uc009ufd.5 
ENSMUST00000113306.4 B3gnt7 ENSMUST00000113306.4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (from RefSeq NM_145222.2) B3GN7_MOUSE ENSMUST00000113306.1 ENSMUST00000113306.2 ENSMUST00000113306.3 NM_145222 Q3U3L9 Q3V283 Q6PA02 Q8BJS5 Q8K0J2 Q8K437 uc007bvk.1 uc007bvk.2 uc007bvk.3 uc007bvk.4 N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non- reducing terminal galactose (Gal) in the linearly growing chain of N- and O-linked keratan sulfate proteoglycans. Cooperates with B4GALT4 galactosyltransferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6- sulfoGlcNAcbeta)1->] within keratan sulfate polymer (By similarity). Involved in biosynthesis of N-linked keratan sulfate proteoglycans in cornea, with an impact on proteoglycan fibril organization and corneal transparency (PubMed:29625490). May play a role in the maintenance of tissue architecture by suppressing cellular motility and invasion (PubMed:12061784). Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Strongly expressed in placenta and colon. Moderately expressed in lung, stomach, small intestine and kidney. Very weakly expressed in cerebrum, cerebellum, heart and testis. Mutant mice are born at the expected Mendelian rate and have normal developmental and reproductive potential. They develop an abnormal corneal ultrastructure characterized by a lack of keratan sulfate proteoglycans that appears to be compensated by increased amount of elongated, branched electron dense chondroitin sulfate/dermatan sulfate proteoglycan filaments. Belongs to the glycosyltransferase 31 family. Golgi membrane endoplasmic reticulum Golgi apparatus protein glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups poly-N-acetyllactosamine biosynthetic process uc007bvk.1 uc007bvk.2 uc007bvk.3 uc007bvk.4 
ENSMUST00000113307.9 Slc25a25 ENSMUST00000113307.9 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25, transcript variant 4 (from RefSeq NM_001290558.1) A2ASZ1 A2ASZ5 A2ASZ8 A2ASZ9 ENSMUST00000113307.1 ENSMUST00000113307.2 ENSMUST00000113307.3 ENSMUST00000113307.4 ENSMUST00000113307.5 ENSMUST00000113307.6 ENSMUST00000113307.7 ENSMUST00000113307.8 Kiaa1896 NM_001290558 Q6NXM8 Q80T78 Q8BHG0 Q8JZT8 Q8VBT4 Q99KD3 SCMC2_MOUSE Scamc2 Slc25a25 uc008jfn.1 uc008jfn.2 uc008jfn.3 uc008jfn.4 Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it could have a broader specificity for adenyl nucleotides. By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways. Reaction=ATP(out) + Mg(2+)(out) + phosphate(in) = ATP(in) + Mg(2+)(in) + phosphate(out); Xref=Rhea:RHEA:65840, ChEBI:CHEBI:18420, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474; Evidence=; Activated by an increase in cytosolic calcium levels that induce a conformational change of the N-terminal regulatory domain, uncapping the channel and allowing transport. Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A2ASZ8-1; Sequence=Displayed; Name=2; IsoId=A2ASZ8-2; Sequence=VSP_031071; Name=3; IsoId=A2ASZ8-3; Sequence=VSP_031071, VSP_031073; Name=4; IsoId=A2ASZ8-4; Sequence=VSP_031072; Name=5; IsoId=A2ASZ8-5; Sequence=VSP_031072, VSP_031073; The regulatory N-terminal domain/NTD, binds calcium in the mitochondrial intermembrane space and regulates the antiporter activity of the transmembrane domain/TMD. In absence of calcium, the apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, inhibiting the transporter activity. Binding of calcium leads to a major conformational change and abolishes the interaction with the transmembrane domain and the inhibition of the transporter activity. The C-terminal mitochondrial carrier domain/transmembrane domain/TMD bears the transmembrane transporter activity. Linker region/H9 could directly block the transport of substrates across the transporter. Homozygous knockout mice lacking Slc25a25 are viable, born at the expected Mendelian ratio and fertile (PubMed:21296886). They display resistance to diet-induced obesity and reduced physical endurance (PubMed:21296886). Cellular metabolism is characterized by reduction in total mitochondrial and non-mitochondrial respiration, which leads to reduction in available ATP (PubMed:21296886). Belongs to the mitochondrial carrier (TC 2.A.29) family. Sequence=AAH19978.1; Type=Erroneous initiation; Evidence=; Sequence=AAH22114.1; Type=Erroneous initiation; Evidence=; Sequence=BAC65850.1; Type=Erroneous initiation; Evidence=; Sequence=CAM18798.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM18799.1; Type=Erroneous gene model prediction; Evidence=; response to dietary excess ATP transmembrane transporter activity calcium ion binding mitochondrion mitochondrial inner membrane response to activity ATP transport membrane integral component of membrane transmembrane transporter activity response to food multicellular organism growth camera-type eye development cellular respiration ATP metabolic process metal ion binding transmembrane transport adipose tissue development calcium ion transmembrane transport uc008jfn.1 uc008jfn.2 uc008jfn.3 uc008jfn.4 
ENSMUST00000113309.9 Armc9 ENSMUST00000113309.9 armadillo repeat containing 9, transcript variant 3 (from RefSeq NM_001310702.2) ARMC9_MOUSE Armc9 ENSMUST00000113309.1 ENSMUST00000113309.2 ENSMUST00000113309.3 ENSMUST00000113309.4 ENSMUST00000113309.5 ENSMUST00000113309.6 ENSMUST00000113309.7 ENSMUST00000113309.8 NM_001310702 Q8BQQ3 Q8BR45 Q8BSX7 Q8C6A6 Q8C889 Q8CA23 Q8CBG2 Q8K112 Q9CYL1 Q9D2I5 Q9D2L3 uc007bvi.1 uc007bvi.2 uc007bvi.3 Involved in ciliogenesis (By similarity). It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (By similarity). Acts as a positive regulator of hedgehog (Hh) signaling (PubMed:29459677). May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip (PubMed:29459677). Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290. Cytoplasm, cytoskeleton, cilium basal body Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localized to the proximal region in cilia. Stimulation of Hh signaling leads to redistribution of ARMC9 toward the ciliary tip within 6 hours, follow by a gradual return to its original proximal location (PubMed:29459677). Localizes to the daughter centriole of the primary cilium in RPE1 cells (By similarity). Event=Alternative splicing; Named isoforms=9; Name=1; IsoId=Q9D2I5-1; Sequence=Displayed; Name=2; IsoId=Q9D2I5-2; Sequence=VSP_023812; Name=3; IsoId=Q9D2I5-3; Sequence=VSP_023815; Name=4; IsoId=Q9D2I5-4; Sequence=VSP_023814, VSP_023816; Name=5; IsoId=Q9D2I5-5; Sequence=VSP_023811; Name=6; IsoId=Q9D2I5-6; Sequence=VSP_023805, VSP_023814, VSP_023816; Name=7; IsoId=Q9D2I5-7; Sequence=VSP_023806, VSP_023809, VSP_023814, VSP_023816; Name=8; IsoId=Q9D2I5-8; Sequence=VSP_023810, VSP_023813; Name=9; IsoId=Q9D2I5-9; Sequence=VSP_023807, VSP_023808; molecular_function cytoplasm cytoskeleton biological_process cell projection organization ciliary basal body cell projection cilium assembly uc007bvi.1 uc007bvi.2 uc007bvi.3 
ENSMUST00000113312.9 Shq1 ENSMUST00000113312.9 Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. (from UniProt Q7TMX5) AK012978 ENSMUST00000113312.1 ENSMUST00000113312.2 ENSMUST00000113312.3 ENSMUST00000113312.4 ENSMUST00000113312.5 ENSMUST00000113312.6 ENSMUST00000113312.7 ENSMUST00000113312.8 Q7TMX5 SHQ1_MOUSE uc009dbz.1 uc009dbz.2 uc009dbz.3 uc009dbz.4 uc009dbz.5 Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. Directly interacts with DKC1 alone, but not in the context of the core trimer composed of DKC1, NOP10 and NHP2, nor in the presence of NAF1. Does not interact with NAF1 (By similarity). Cytoplasm, cytosol Nucleus, nucleoplasm Note=May at least partially shuttle between cytosol and nucleoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TMX5-1; Sequence=Displayed; Name=2; IsoId=Q7TMX5-2; Sequence=VSP_027961; Belongs to the SHQ1 family. box H/ACA snoRNP assembly nucleus nucleoplasm cytoplasm cytosol ribonucleoprotein complex assembly positive regulation of apoptotic process unfolded protein binding negative regulation of rRNA processing uc009dbz.1 uc009dbz.2 uc009dbz.3 uc009dbz.4 uc009dbz.5 
ENSMUST00000113314.3 Sult1d1 ENSMUST00000113314.3 sulfotransferase family 1D, member 1 (from RefSeq NM_016771.3) ENSMUST00000113314.1 ENSMUST00000113314.2 NM_016771 O35401 Q3UZZ6 Q6NZD1 Q9R2C2 ST1D1_MOUSE St1d1 uc008xyo.1 uc008xyo.2 uc008xyo.3 uc008xyo.4 Sulfotransferase with broad substrate specificity that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, such as dopamine, prostaglandins, leukotriene E4, drugs and xenobiotic compounds. Has sulfotransferase activity towards p-nitrophenol, 2-naphthylamine and minoxidil (in vitro). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Cytoplasm Detected in kidney and liver. Detected in kidney collecting duct cells. Up-regulated in liver and kidney by dexamethasone, a glucocorticoid analog. Belongs to the sulfotransferase 1 family. Sequence=AAC99889.1; Type=Frameshift; Evidence=; sulfate assimilation aryl sulfotransferase activity cytoplasm catecholamine metabolic process lipid metabolic process sulfotransferase activity transferase activity sulfation uc008xyo.1 uc008xyo.2 uc008xyo.3 uc008xyo.4 
ENSMUST00000113334.8 Ciz1 ENSMUST00000113334.8 Ciz1 (from geneSymbol) BC018483 Ciz1 ENSMUST00000113334.1 ENSMUST00000113334.2 ENSMUST00000113334.3 ENSMUST00000113334.4 ENSMUST00000113334.5 ENSMUST00000113334.6 ENSMUST00000113334.7 Q8VEH2 Q8VEH2_MOUSE uc289vbm.1 uc289vbm.2 nucleic acid binding nucleus nucleoplasm plasma membrane zinc ion binding cyclin binding positive regulation of DNA-dependent DNA replication initiation metal ion binding maintenance of protein location in nucleus uc289vbm.1 uc289vbm.2 
ENSMUST00000113337.10 Ubr2 ENSMUST00000113337.10 ubiquitin protein ligase E3 component n-recognin 2, transcript variant 1 (from RefSeq NM_146078.4) ENSMUST00000113337.1 ENSMUST00000113337.2 ENSMUST00000113337.3 ENSMUST00000113337.4 ENSMUST00000113337.5 ENSMUST00000113337.6 ENSMUST00000113337.7 ENSMUST00000113337.8 ENSMUST00000113337.9 Kiaa0349 NM_146078 Q6DIB9 Q6WKZ8 Q80U31 Q8BUL9 Q8CGW0 Q8K2I6 Q8R0V7 Q8R130 UBR2_MOUSE uc012aus.1 uc012aus.2 uc012aus.3 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:14585983, PubMed:31268597, PubMed:30872531). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:14585983, PubMed:31268597, PubMed:30872531). Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (PubMed:14585983, PubMed:20080676). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity). Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (PubMed:28708824). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172). Catalyzes ubiquitination and degradation of the N-terminal part of Nlrp1b following Nlrp1b activation by pathogens and other damage- associated signals: ubiquitination promotes degradation of the N- terminal part and subsequent release of the cleaved C-terminal part of Nlrp1b, which polymerizes and forms the Nlrp1b inflammasome followed by host cell pyroptosis (PubMed:31268597, PubMed:30872531). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence= Protein modification; protein ubiquitination. Interacts with UBE2B; promotes the UBE2B-H2A interaction and the ubiquitination of histone H2A by UBE2B and UBR2 (PubMed:14585983, PubMed:20080676). Interacts with RECQL4 (By similarity). Interacts with Tex19.1 and Tex19.2; does not lead to Tex19.1 degradation and stabilizes it (PubMed:21103378). Interacts with L1RE1 (PubMed:28806172). Interacts with CASP8 (By similarity). Interacts with ATXN3 (By similarity). Interacts with UBE2O (PubMed:31268597). Nucleus romosome Note=Associated with chromatin during meiosis. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6WKZ8-1; Sequence=Displayed; Name=2; IsoId=Q6WKZ8-2; Sequence=VSP_015173; Name=3; IsoId=Q6WKZ8-3; Sequence=VSP_015172, VSP_015173; Highly expressed in skeletal muscle. Also expressed in heart, kidney and testis. Expressed in acinar cells of the pancreas. In testes, expressed primarily in spermatocytes. Expressed in cerebellum (PubMed:28806172). In models of cancer cachexia, induced specifically at the onset and during the progression of muscle wasting. The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif. The UBR-type zinc finger forms a pocket that mediates recognition of type 1 N-degrons. It exhibits preference for Arginine in first position, has poor affinity for histidine, and doesn't bind acetylated peptides (By similarity). Male mice are viable but not fertile, due to massive apoptosis of spermatocytes. They have a reduction of testis weight of 68% and no detectable sperm in their epididymis. The seminiferous tubules contain reduced numbers of post-meiotic round, elongated spermatids and accumulation of pyknotic and zygotene-like nuclei. Female mice show severe prenatal lethality, but the rare surviving are fertile. Fibroblast cells display spontaneous chromosome instability and fragility (PubMed:14585983, PubMed:16488448, PubMed:28708824). UBR1 and UBR2 double knockout embryos die at midgestation, with defects in neurogenesis and cardiovascular development. These defects included reduced proliferation as well as precocious migration and differentiation of neural progenitor cells (PubMed:16606826). Belongs to the UBR1 family. Sequence=AAH25617.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH31403.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC65536.3; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; ubiquitin ligase complex protein binding nucleus cytoplasm chromatin silencing ubiquitin-dependent protein catabolic process reciprocal meiotic recombination male meiosis male meiosis I spermatogenesis zinc ion binding negative regulation of transposition protein ubiquitination transferase activity protein catabolic process negative regulation of TOR signaling histone H2A ubiquitination metal ion binding ubiquitin protein ligase activity leucine binding cellular response to leucine ubiquitin-dependent protein catabolic process via the N-end rule pathway chromatin uc012aus.1 uc012aus.2 uc012aus.3 
ENSMUST00000113348.8 Cldn34c1 ENSMUST00000113348.8 claudin 34C1, transcript variant 1 (from RefSeq NM_028426.2) 3110007F17Rik Cldn34c1 ENSMUST00000113348.1 ENSMUST00000113348.2 ENSMUST00000113348.3 ENSMUST00000113348.4 ENSMUST00000113348.5 ENSMUST00000113348.6 ENSMUST00000113348.7 NM_028426 Q8K193 Q8K193_MOUSE uc009uem.1 uc009uem.2 uc009uem.3 uc009uem.4 Cell junction, tight junction Belongs to the claudin family. molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc009uem.1 uc009uem.2 uc009uem.3 uc009uem.4 
ENSMUST00000113355.9 Frmd4b ENSMUST00000113355.9 FERM domain containing 4B, transcript variant 3 (from RefSeq NM_145148.2) ENSMUST00000113355.1 ENSMUST00000113355.2 ENSMUST00000113355.3 ENSMUST00000113355.4 ENSMUST00000113355.5 ENSMUST00000113355.6 ENSMUST00000113355.7 ENSMUST00000113355.8 FRM4B_MOUSE NM_145148 Q3V1S1 Q920B0 Q920B1 Q9ESP9 uc009daw.1 uc009daw.2 uc009daw.3 uc009daw.4 Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (PubMed:20080746). Plays a redundant role with FRMD4A in epithelial polarization (PubMed:20080746). Interacts with CYTH3 (PubMed:11445584, PubMed:20080746). Interacts with PARD3 (PubMed:20080746). Interacts with CYTH1. Cytoplasm, cytoskeleton Cell junction, tight junction Cell junction, adherens junction Note=Colocalized with PARD3 at adherens junction and tight junction (PubMed:20080746). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q920B0-1; Sequence=Displayed; Name=2; IsoId=Q920B0-2; Sequence=VSP_040896; Isoform 1 is expressed in the brain. Isoform 2 is expressed in the lung (at protein level). Sequence=AAL26916.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; ruffle protein binding cytoplasm cytoskeleton adherens junction bicellular tight junction cell junction establishment of epithelial cell polarity uc009daw.1 uc009daw.2 uc009daw.3 uc009daw.4 
ENSMUST00000113360.8 Cab39 ENSMUST00000113360.8 calcium binding protein 39, transcript variant 1 (from RefSeq NM_133781.6) CAB39_MOUSE ENSMUST00000113360.1 ENSMUST00000113360.2 ENSMUST00000113360.3 ENSMUST00000113360.4 ENSMUST00000113360.5 ENSMUST00000113360.6 ENSMUST00000113360.7 Mo25 NM_133781 Q06138 Q8VDZ8 uc007bum.1 uc007bum.2 uc007bum.3 uc007bum.4 Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Cytoplasm Transcribed during early mouse development. Detected at all developmental stages from the egg through the blastocyst, most abundant at the 2-cell stage. Belongs to the Mo25 family. protein serine/threonine kinase activity calcium ion binding cytoplasm positive regulation of peptidyl-threonine phosphorylation peptidyl-serine phosphorylation kinase binding signal transduction by protein phosphorylation protein kinase activator activity activation of protein kinase activity macromolecular complex intracellular signal transduction protein serine/threonine kinase activator activity protein heterooligomerization positive regulation of protein serine/threonine kinase activity uc007bum.1 uc007bum.2 uc007bum.3 uc007bum.4 
ENSMUST00000113367.2 Ddx43 ENSMUST00000113367.2 DEAD box helicase 43 (from RefSeq NM_001191044.1) D3Z6P9 D3Z6P9_MOUSE Ddx43 ENSMUST00000113367.1 NM_001191044 uc012gxe.1 uc012gxe.2 uc012gxe.3 Belongs to the DEAD box helicase family. nucleotide binding nucleic acid binding RNA binding helicase activity ATP binding nucleus cytoplasm hydrolase activity ribonucleoprotein complex uc012gxe.1 uc012gxe.2 uc012gxe.3 
ENSMUST00000113373.2 Uba6 ENSMUST00000113373.2 Reaction=ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]- L-cysteine.; EC=6.2.1.45; Evidence=; (from UniProt D3Z061) AK029769 D3Z061 D3Z061_MOUSE ENSMUST00000113373.1 Uba6 uc290wtc.1 uc290wtc.2 Reaction=ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]- L-cysteine.; EC=6.2.1.45; Evidence=; Protein modification; protein ubiquitination. Belongs to the ubiquitin-activating E1 family. cellular protein modification process small protein activating enzyme activity uc290wtc.1 uc290wtc.2 
ENSMUST00000113383.4 Flrt1 ENSMUST00000113383.4 fibronectin leucine rich transmembrane protein 1 (from RefSeq NM_201411.2) A0A452J8F8 ENSMUST00000113383.1 ENSMUST00000113383.2 ENSMUST00000113383.3 FLRT1_MOUSE Flrt1 NM_201411 Q14DT7 Q6RKD8 Q6RKD9 uc008gkh.1 uc008gkh.2 uc008gkh.3 uc008gkh.4 uc008gkh.5 uc008gkh.6 uc008gkh.7 Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases (PubMed:16872596, PubMed:20421966). Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length (PubMed:20421966). May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3 (PubMed:22405201). Interacts with FGFR1 (PubMed:16872596). Interacts (via extracellular domain) with ADGRL1/LPHN1 and ADGRL3 (via olfactomedin- like domain) (PubMed:22405201). Cell membrane ingle-pass membrane protein doplasmic reticulum membrane Cytoplasmic vesicle membrane toplasm, perinuclear region Cell junction, focal adhesion Secreted Cell projection, neuron projection Cell junction Note=In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles (PubMed:16872596, PubMed:20421966). Detected along neurites and at contacts between neurite termini and other cells (PubMed:20421966). Proteolytic cleavage gives rise to a shedded ectodomain (PubMed:21673655). Event=Alternative initiation; Named isoforms=2; Name=2; IsoId=Q6RKD8-2; Sequence=Displayed; Name=1; IsoId=Q6RKD8-1; Sequence=VSP_062135; Detected in brain (at protein level). Detected at comparable levels in embryonic brain and in brain from ten day old animals (at protein level) (PubMed:16872596). Detected in neuroectoderm at 7.5 dpc. Detected in midbrain between 8.5 and 9 dpc (PubMed:18448090). Detected at 9.5 dpc in embryonic midbrain adjacent to the boundary between midbrain and forebrain (PubMed:16872596). At 10.5 dpc, expression is also detected in the eye, throughout the brain, the dorsal root ganglia and trigeminal ganglia, and in cells adjacent to the urogenital ridge in the torso (PubMed:16872596, PubMed:18448090). At 11 dpc, expression in midbrain is tightly restricted to the boundary between midbrain and hindbrain (PubMed:16872596). Up-regulated by FGF2. Phosphorylated in response to FGFR1 signaling, but is not a direct substrate of FGFR1 or SRC. A mutant where the Tyr phosphorylation sites have been replaced by Phe displays constitutive FGFR1-dependent activation of downstream MAP kinases. N-glycosylated. Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. [Isoform 2]: The curated signal sequence though non- canonical is consistent with the proven topology. [Isoform 1]: Has a predicted canonical N-terminal signal sequence that is consistent with the proven topology of the protein. fibroblast growth factor receptor binding extracellular region extracellular space cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane cell-cell junction focal adhesion cell adhesion multicellular organism development fibroblast growth factor receptor signaling pathway membrane integral component of membrane dendrite development cell junction cytoplasmic vesicle membrane cytoplasmic vesicle neuronal cell body membrane cell projection neuron projection terminus perinuclear region of cytoplasm positive regulation of synapse assembly neuron projection extension uc008gkh.1 uc008gkh.2 uc008gkh.3 uc008gkh.4 uc008gkh.5 uc008gkh.6 uc008gkh.7 
ENSMUST00000113402.4 Gm7609 ENSMUST00000113402.4 predicted pseudogene 7609 (from RefSeq NM_001081746.1) A0A668KL92 A0A668KL92_MOUSE ENSMUST00000113402.1 ENSMUST00000113402.2 ENSMUST00000113402.3 Gm7609 NM_001081746 uc287jwk.1 uc287jwk.2 This gene is one of several duplicated genes in a repeat cluster in the homogeneously staining region (HSR) of chromosome 1. It is an Sp100-rs gene copy, which arose by duplication following the fusion of the Csprs (component of Sp100-rs) gene and the 5' part of the Sp100 (nuclear antigen Sp100) gene. The coding sequence of this gene is intact compared to that of the Csprs gene, and therefore NCBI represents this as a protein-coding gene. However, it is also possible to interpret this fusion gene as a pseudogene of the Sp100 gene. It is unknown if this gene produces a protein in vivo. [provided by RefSeq, Mar 2011]. ##Evidence-Data-START## Transcript exon combination :: BC059276.1, BF537368.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein uc287jwk.1 uc287jwk.2 
ENSMUST00000113403.8 Epha5 ENSMUST00000113403.8 Eph receptor A5, transcript variant 4 (from RefSeq NM_001402752.1) E9PUQ0 E9PUQ0_MOUSE ENSMUST00000113403.1 ENSMUST00000113403.2 ENSMUST00000113403.3 ENSMUST00000113403.4 ENSMUST00000113403.5 ENSMUST00000113403.6 ENSMUST00000113403.7 Epha5 NM_001402752 uc290wsd.1 uc290wsd.2 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Membrane ; Single- pass type I membrane protein nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity ATP binding integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation ephrin receptor signaling pathway uc290wsd.1 uc290wsd.2 
ENSMUST00000113407.11 Gm7592 ENSMUST00000113407.11 predicted gene 7592 (from RefSeq NM_001378663.1) A0A668KLT6 A0A668KLT6_MOUSE ENSMUST00000113407.1 ENSMUST00000113407.10 ENSMUST00000113407.2 ENSMUST00000113407.3 ENSMUST00000113407.4 ENSMUST00000113407.5 ENSMUST00000113407.6 ENSMUST00000113407.7 ENSMUST00000113407.8 ENSMUST00000113407.9 Gm7592 NM_001378663 uc287jwi.1 uc287jwi.2 Membrane ; Multi- pass membrane protein uc287jwi.1 uc287jwi.2 
ENSMUST00000113409.8 Zfp711 ENSMUST00000113409.8 zinc finger protein 711, transcript variant 1 (from RefSeq NM_177747.4) E9PUP8 E9PUP8_MOUSE ENSMUST00000113409.1 ENSMUST00000113409.2 ENSMUST00000113409.3 ENSMUST00000113409.4 ENSMUST00000113409.5 ENSMUST00000113409.6 ENSMUST00000113409.7 NM_177747 Zfp711 uc009udl.1 uc009udl.2 Nucleus nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding positive regulation of transcription, DNA-templated metal ion binding uc009udl.1 uc009udl.2 
ENSMUST00000113412.3 2010106E10Rik ENSMUST00000113412.3 RIKEN cDNA 2010106E10 gene, transcript variant 1 (from RefSeq NM_001168590.1) 2010106E10Rik A2ANY3 A2ANY3_MOUSE ENSMUST00000113412.1 ENSMUST00000113412.2 NM_001168590 uc012hoa.1 uc012hoa.2 uc012hoa.3 molecular_function cellular_component biological_process membrane integral component of membrane uc012hoa.1 uc012hoa.2 uc012hoa.3 
ENSMUST00000113422.9 Hdx ENSMUST00000113422.9 highly divergent homeobox, transcript variant 1 (from RefSeq NM_001080549.2) ENSMUST00000113422.1 ENSMUST00000113422.2 ENSMUST00000113422.3 ENSMUST00000113422.4 ENSMUST00000113422.5 ENSMUST00000113422.6 ENSMUST00000113422.7 ENSMUST00000113422.8 HDX_MOUSE NM_001080549 Q14B69 Q14B70 uc009udb.1 uc009udb.2 uc009udb.3 Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14B70-1; Sequence=Displayed; Name=2; IsoId=Q14B70-2; Sequence=VSP_027709; DNA binding cellular_component nucleus biological_process uc009udb.1 uc009udb.2 uc009udb.3 
ENSMUST00000113423.10 Bad ENSMUST00000113423.10 BCL2-associated agonist of cell death, transcript variant 2 (from RefSeq NM_001285453.1) Bad ENSMUST00000113423.1 ENSMUST00000113423.2 ENSMUST00000113423.3 ENSMUST00000113423.4 ENSMUST00000113423.5 ENSMUST00000113423.6 ENSMUST00000113423.7 ENSMUST00000113423.8 ENSMUST00000113423.9 NM_001285453 Q3U9H3 Q3U9H3_MOUSE uc008gjo.1 uc008gjo.2 uc008gjo.3 uc008gjo.4 apoptotic process uc008gjo.1 uc008gjo.2 uc008gjo.3 uc008gjo.4 
ENSMUST00000113434.3 Gm15737 ENSMUST00000113434.3 predicted gene 15737 (from RefSeq NR_169058.1) ENSMUST00000113434.1 ENSMUST00000113434.2 NR_169058 uc291hft.1 uc291hft.2 uc291hft.3 uc291hft.1 uc291hft.2 uc291hft.3 
ENSMUST00000113437.9 Ccl20 ENSMUST00000113437.9 C-C motif chemokine ligand 20, transcript variant 1 (from RefSeq NM_016960.2) Ccl20 ENSMUST00000113437.1 ENSMUST00000113437.2 ENSMUST00000113437.3 ENSMUST00000113437.4 ENSMUST00000113437.5 ENSMUST00000113437.6 ENSMUST00000113437.7 ENSMUST00000113437.8 NM_016960 Q54AI7 Q54AI7_MOUSE uc007bsk.1 uc007bsk.2 uc007bsk.3 uc007bsk.4 Secreted Belongs to the intercrine beta (chemokine CC) family. cytokine activity extracellular region extracellular space chemotaxis immune response chemokine activity CCR6 chemokine receptor binding calcium-mediated signaling using intracellular calcium source cell chemotaxis positive regulation of T cell migration uc007bsk.1 uc007bsk.2 uc007bsk.3 uc007bsk.4 
ENSMUST00000113438.8 Adamts9 ENSMUST00000113438.8 ADAM metallopeptidase with thrombospondin type 1 motif 9 (from RefSeq NM_175314.4) Adamts9 E9PUN6 E9PUN6_MOUSE ENSMUST00000113438.1 ENSMUST00000113438.2 ENSMUST00000113438.3 ENSMUST00000113438.4 ENSMUST00000113438.5 ENSMUST00000113438.6 ENSMUST00000113438.7 NM_175314 uc009czb.1 uc009czb.2 uc009czb.3 uc009czb.4 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix Lacks conserved residue(s) required for the propagation of feature annotation. endopeptidase activity metalloendopeptidase activity extracellular space endoplasmic reticulum proteolysis metallopeptidase activity zinc ion binding response to bacterium cell surface extracellular matrix intracellular membrane-bounded organelle positive regulation of melanocyte differentiation regulation of developmental pigmentation uc009czb.1 uc009czb.2 uc009czb.3 uc009czb.4 
ENSMUST00000113440.2 Ccdc88b ENSMUST00000113440.2 coiled-coil domain containing 88B (from RefSeq NM_001081291.1) B2RX63 CC88B_MOUSE Ccdc88 ENSMUST00000113440.1 NM_001081291 Q4QRL3 uc008gjb.1 uc008gjb.2 Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation and during the course of infection with the mouse malaria parasite Plasmodium berghei (PubMed:25403443). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (By similarity). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). Homodimer (By similarity). Interacts with DOCK8 (By similarity). Interacts (via C-terminus) with intact microtubules (By similarity). Interacts with dynein-dynactin motor complex (By similarity). Interacts (via C-terminus) with HSPA5 (PubMed:21289099). Membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton, microtubule organizing center Endoplasmic reticulum Golgi apparatus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q4QRL3-1; Sequence=Displayed; Name=2; IsoId=Q4QRL3-2; Sequence=VSP_030966; Abundantly expressed in immune cells, including both CD4(+) and CD8(+) T-cells and in myeloid cells (at protein level) (PubMed:25403443). Expressed in endothelium (at protein level) (PubMed:21289099). Expressed specifically in spleen, bone marrow, lymph nodes and thymus (PubMed:25403443). Expressed in liver and heart (PubMed:21289099). Mice show defects in T-cell functions including impaired maturation, significantly reduced activation, reduced cell division as well as impaired cytokine production in response to specific or non-specific stimulation and during the course of infection with the mouse malaria parasite Plasmodium berghei. Belongs to the CCDC88 family. positive regulation of cytokine production cytoplasm endoplasmic reticulum Golgi apparatus centrosome cytoskeleton microtubule binding membrane cytoskeleton-dependent intracellular transport cytoplasmic microtubule organization positive regulation of T cell proliferation defense response to protozoan positive regulation of T cell activation dynein light intermediate chain binding uc008gjb.1 uc008gjb.2 
ENSMUST00000113442.3 ENSMUSG00000121821 ENSMUST00000113442.3 ENSMUSG00000121821 (from geneSymbol) ENSMUST00000113442.1 ENSMUST00000113442.2 LF193652 uc290bfg.1 uc290bfg.2 uc290bfg.1 uc290bfg.2 
ENSMUST00000113451.9 Slc22a12 ENSMUST00000113451.9 solute carrier family 22 (organic anion/cation transporter), member 12 (from RefSeq NM_009203.3) A0A0R4J1I9 A0A0R4J1I9_MOUSE ENSMUST00000113451.1 ENSMUST00000113451.2 ENSMUST00000113451.3 ENSMUST00000113451.4 ENSMUST00000113451.5 ENSMUST00000113451.6 ENSMUST00000113451.7 ENSMUST00000113451.8 NM_009203 Slc22a12 uc012bho.1 uc012bho.2 uc012bho.3 uc012bho.4 uc012bho.5 Membrane ; Multi- pass membrane protein plasma membrane urate transmembrane transporter activity urate transport membrane integral component of membrane apical plasma membrane transmembrane transporter activity PDZ domain binding response to drug urate metabolic process transmembrane transport uc012bho.1 uc012bho.2 uc012bho.3 uc012bho.4 uc012bho.5 
ENSMUST00000113457.9 Col4a3 ENSMUST00000113457.9 collagen, type IV, alpha 3 (from RefSeq NM_007734.3) CO4A3_MOUSE Col4a3 ENSMUST00000113457.1 ENSMUST00000113457.2 ENSMUST00000113457.3 ENSMUST00000113457.4 ENSMUST00000113457.5 ENSMUST00000113457.6 ENSMUST00000113457.7 ENSMUST00000113457.8 NM_007734 Q61430 Q61435 Q8CCD6 Q9QZS0 uc007brv.1 uc007brv.2 uc007brv.3 Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms. There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. The alpha 3(IV) chain forms a triple helical protomer with alpha 4(IV) and alpha 5(IV); this triple helical structure dimerizes through NC1-NC1 domain interactions such that the alpha 3(IV), alpha 4(IV) and alpha 5(IV) chains of one protomer connect with the alpha 5(IV), alpha 4(IV) and alpha 3(IV) chains of the opposite promoter, respectively (PubMed:14633121). Interacts with ITGB3 (By similarity). Associates with LAMB2 at the neuromuscular junction and in GBM (PubMed:7962065). Secreted, extracellular space, extracellular matrix, basement membrane te=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). Highly expressed in kidney and lung. Detected at lower levels in heart, muscle and skin. Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues. Phosphorylated. Thought to be phosphorylated by CERT, but CERT does not have kinase activity. Mice exhibit normal pregnancy and wound healing, but consistent with the human hereditary disorder Alport syndrome they develop a progressive glomerulonephritis with microhematuria and proteinuria. Belongs to the type IV collagen family. integrin binding extracellular matrix structural constituent extracellular region collagen trimer collagen type IV trimer basement membrane extracellular space endoplasmic reticulum activation of cysteine-type endopeptidase activity involved in apoptotic process cell adhesion cell surface receptor signaling pathway cell proliferation response to glucose negative regulation of angiogenesis extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix glomerular basement membrane development collagen-activated tyrosine kinase receptor signaling pathway intracellular membrane-bounded organelle endothelial cell apoptotic process uc007brv.1 uc007brv.2 uc007brv.3 
ENSMUST00000113463.8 Nr2c2 ENSMUST00000113463.8 nuclear receptor subfamily 2, group C, member 2, transcript variant 3 (from RefSeq NM_001410478.1) ENSMUST00000113463.1 ENSMUST00000113463.2 ENSMUST00000113463.3 ENSMUST00000113463.4 ENSMUST00000113463.5 ENSMUST00000113463.6 ENSMUST00000113463.7 G3X9W4 G3X9W4_MOUSE NM_001410478 Nr2c2 uc291hew.1 uc291hew.2 Nucleus Belongs to the nuclear hormone receptor family. NR2 subfamily. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity nucleus nucleoplasm regulation of transcription, DNA-templated zinc ion binding steroid hormone mediated signaling pathway sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding protein heterodimerization activity uc291hew.1 uc291hew.2 
ENSMUST00000113466.2 Fgd5 ENSMUST00000113466.2 Cytoplasm, cytoskeleton (from UniProt E9QLU9) AK220153 E9QLU9 E9QLU9_MOUSE ENSMUST00000113466.1 Fgd5 uc291her.1 uc291her.2 Cytoplasm, cytoskeleton Rho guanyl-nucleotide exchange factor activity regulation of Rho protein signal transduction metal ion binding uc291her.1 uc291her.2 
ENSMUST00000113470.3 Prdm12 ENSMUST00000113470.3 PR domain containing 12, transcript variant 2 (from RefSeq NM_001427358.1) A2AJ77 ENSMUST00000113470.1 ENSMUST00000113470.2 Gm998 NM_001427358 PRD12_MOUSE uc012bto.1 uc012bto.2 Involved in the positive regulation of histone H3-K9 dimethylation. Nucleus Expression starts around 9.0 dpc in the neural folds, which give rise to neural crest cells. Neural crest cells develop into various tissues, including the sensory ganglia that contain nociceptor cell bodies. Prominently expressed in sensory spinal ganglia (dorsal root ganglia) but not in sympathetic ganglia during the time when sensory neurons emerge (10.5 dpc-13.5 dpc), mature and differentiate (14.5 dpc-postnatal day 14). Belongs to the class V-like SAM-binding methyltransferase superfamily. RNA polymerase II regulatory region sequence-specific DNA binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated methyltransferase activity transferase activity sensory perception of pain neurogenesis neuron projection development chromatin DNA binding methylation sequence-specific DNA binding metal ion binding detection of temperature stimulus involved in sensory perception of pain positive regulation of histone H3-K9 methylation positive regulation of histone H3-K9 dimethylation histone methyltransferase binding uc012bto.1 uc012bto.2 
ENSMUST00000113476.8 Rasgrp2 ENSMUST00000113476.8 Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. (from UniProt Q9QUG9) AF081193 ENSMUST00000113476.1 ENSMUST00000113476.2 ENSMUST00000113476.3 ENSMUST00000113476.4 ENSMUST00000113476.5 ENSMUST00000113476.6 ENSMUST00000113476.7 GRP2_MOUSE O09004 Q80WC0 Q8BSC8 Q9QUG9 uc289qmy.1 uc289qmy.2 Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. Forms a signaling complex with RAP1 and BRAF. Interacts with F-actin (By similarity). Interacts with RAP1. Cytoplasm, cytosol Cell membrane ; Peripheral membrane protein Synapse, synaptosome Cell projection, ruffle membrane ; Peripheral membrane protein Note=Found both in the cytosol and associated with membranes. Enriched at juxtamembrane areas and membrane ruffles. Localizes to the cell bodies and axons of striatal neurons. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CalDAG-GEF1a; IsoId=Q9QUG9-1; Sequence=Displayed; Name=2; IsoId=Q9QUG9-2; Sequence=VSP_030579; Name=3; Synonyms=CalDAG-GEF1b; IsoId=Q9QUG9-3; Sequence=VSP_030577, VSP_030578; Detected in megakaryocytes, platelet and neutrophils but not in lymphocytes (at protein level). Isoform 1 and isoform 3 are detected in brain basal glanglia, heart, lung, spleen, liver and kidney interstitial cells. Expressed in embryo with higher expression between 15 dpc and 17 dpc. The N-terminal Ras-GEF domain mediates association with F- actin. Mice have a combination of defects in leukocytes and platelet functions which are reminiscent of the human leukocyte adhesion deficiency type III syndrome (LAD3). They display bleeding diathesis due to a defect in platelet aggregation and are resistant to collagen-induced thrombosis. In parallel, they also display impaired response to acute inflammation associated with defects in beta-1 and beta-2 integrin-mediated adhesion of neutrophils. [Isoform 3]: The corresponding protein is not undetectable. Belongs to the RASGRP family. Sequence=BAC28797.1; Type=Erroneous initiation; Evidence=; guanyl-nucleotide exchange factor activity calcium ion binding cytoplasm cytosol plasma membrane small GTPase mediated signal transduction membrane cell junction ruffle membrane intracellular signal transduction cell projection neuron projection positive regulation of GTPase activity synapse metal ion binding cellular response to calcium ion uc289qmy.1 uc289qmy.2 
ENSMUST00000113480.2 Cysltr1 ENSMUST00000113480.2 cysteinyl leukotriene receptor 1, transcript variant 1 (from RefSeq NM_021476.5) CLTR1_MOUSE Cyslt1 Cyslt1r ENSMUST00000113480.1 NM_021476 Q544P1 Q99JA4 Q9JJ71 Q9JK47 uc009ubt.1 uc009ubt.2 uc009ubt.3 uc009ubt.4 Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. Q99JA4; Q6NS65: Gpr17; NbExp=2; IntAct=EBI-15791392, EBI-15791369; Cell membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=Q99JA4-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q99JA4-2; Sequence=VSP_001921; Widely expressed, with higher expression in the lung and skin, intermediate levels in the heart, kidney and stomach and lower levels in several other tissues. Isoform 1 is the most abundant form in all tested tissues. MK-571, a selective antagonist, was shown to inhibit eosinophilia, bronchial hyperreactivity and microvascular leakage. Zafirlukast (Accolate) and pranlukast (Onon) were also shown to be selective antagonists. Belongs to the G-protein coupled receptor 1 family. inflammatory response to antigenic stimulus G-protein coupled receptor activity galanin receptor activity leukotriene receptor activity protein binding plasma membrane integral component of plasma membrane calcium ion transport chemotaxis inflammatory response signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway neuropeptide signaling pathway G-protein coupled peptide receptor activity membrane integral component of membrane positive regulation of angiogenesis positive regulation of vasoconstriction leukotriene signaling pathway uc009ubt.1 uc009ubt.2 uc009ubt.3 uc009ubt.4 
ENSMUST00000113482.8 Fubp3 ENSMUST00000113482.8 far upstream element (FUSE) binding protein 3, transcript variant 5 (from RefSeq NM_001363081.1) A2AJ72 A2AJ72_MOUSE ENSMUST00000113482.1 ENSMUST00000113482.2 ENSMUST00000113482.3 ENSMUST00000113482.4 ENSMUST00000113482.5 ENSMUST00000113482.6 ENSMUST00000113482.7 Fubp3 NM_001363081 uc008jdx.1 uc008jdx.2 uc008jdx.3 uc008jdx.4 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding single-stranded DNA binding RNA binding nucleus cytoplasm transcription, DNA-templated positive regulation of gene expression positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc008jdx.1 uc008jdx.2 uc008jdx.3 uc008jdx.4 
ENSMUST00000113488.8 Sf1 ENSMUST00000113488.8 splicing factor 1, transcript variant 18 (from RefSeq NM_001403449.1) D3YZD0 D3YZD0_MOUSE ENSMUST00000113488.1 ENSMUST00000113488.2 ENSMUST00000113488.3 ENSMUST00000113488.4 ENSMUST00000113488.5 ENSMUST00000113488.6 ENSMUST00000113488.7 NM_001403449 Sf1 uc289qmj.1 uc289qmj.2 Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns. Nucleus Belongs to the BBP/SF1 family. mRNA splicing, via spliceosome nucleic acid binding RNA binding zinc ion binding pre-mRNA branch point binding uc289qmj.1 uc289qmj.2 
ENSMUST00000113493.8 Exoc1 ENSMUST00000113493.8 exocyst complex component 1, transcript variant 1 (from RefSeq NM_027270.3) ENSMUST00000113493.1 ENSMUST00000113493.2 ENSMUST00000113493.3 ENSMUST00000113493.4 ENSMUST00000113493.5 ENSMUST00000113493.6 ENSMUST00000113493.7 Exoc1 NM_027270 Q6P1Y9 Q6P1Y9_MOUSE Sec3l1 uc008xuz.1 uc008xuz.2 uc008xuz.3 uc008xuz.4 Belongs to the SEC3 family. exocyst cytoplasm exocytosis phosphatidylinositol-mediated signaling positive regulation of protein secretion cytoplasmic side of apical plasma membrane uc008xuz.1 uc008xuz.2 uc008xuz.3 uc008xuz.4 
ENSMUST00000113504.10 Men1 ENSMUST00000113504.10 Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression (By similarity). May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. (from UniProt O88559) AK154371 ENSMUST00000113504.1 ENSMUST00000113504.2 ENSMUST00000113504.3 ENSMUST00000113504.4 ENSMUST00000113504.5 ENSMUST00000113504.6 ENSMUST00000113504.7 ENSMUST00000113504.8 ENSMUST00000113504.9 MEN1_MOUSE O88559 Q3U491 Q8CI72 Q91UZ7 uc289qle.1 uc289qle.2 Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression (By similarity). May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. Component of the MLL-HCF complex, at least composed of KMT2A/MLL1, MEN1, ASH2L, RBBP5, DPY30, WDR5, HCFC1 and HCFC2 (By similarity). Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4, MEN1, ASH2L, RBBP5, DPY30 and WDR5 (By similarity). Interacts with POLR2B (By similarity). Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms (By similarity). Interacts with FANCD2 and DBF4 (By similarity). Interacts with SMAD3, but not with SMAD2, nor SMAD4 (By similarity). Directly interacts with NFKB1, NFKB2 and RELA (By similarity). Interacts with JUND (via MBM motif); inhibits the interaction of JUND with MAPK10 and the phosphorylation of JUND by MAP kinases MAPK8 and MAPK10 (PubMed:9989505). Interacts with KMT2A (via MBM motif) (By similarity). The KMT2A-MEN1 complex interacts with PSIP1 with a greater affinity as MEN1 enhances interaction of KMT2A with PSIP1 (By similarity). O88559; Q9Z0Y9: Nr1h3; NbExp=3; IntAct=EBI-3990176, EBI-5276764; O88559; P23204: Ppara; NbExp=2; IntAct=EBI-3990176, EBI-5273083; Nucleus Note=May be perinuclear in testis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88559-1; Sequence=Displayed; Name=2; IsoId=O88559-2; Sequence=VSP_041100; Widely expressed, with high levels in hippocampus, cerebral cortex, testis and thymus (at protein level). Also expressed at high levels in pancreatic islets, ovary and bone marrow. In the brain, highest expression in hippocampus pyramidal nerve cells (at protein level). In the testis, may be expressed in spermatogonia (at protein level). Low expression, if any, in skeletal muscle. First detected at 7 dpc. At 13.5 dpc, expressed throughout the embryo, including forelimb, gut, head, heart and lung. At 17 dpc, expression becomes more restricted, with high levels mainly in the thymus, skeletal muscle, brain and spinal cord. Homozygous mice die in utero at 11.5-12.5 dpc. At 9 months of age, heterozygous mice develop pancreatic islet lesions, from hyperplasia to insulin-producing islet cell tumors, and frequently parathyroid adenomas. Larger, more numerous tumors involving pancreatic islets, parathyroids, thyroid, adrenal cortex and pituitary are seen by 16 months. All tumors show loss of the wild-type allele. Sequence=BAE32542.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter MAPK cascade four-way junction DNA binding Y-form DNA binding nuclear chromosome, telomeric region chromatin nuclear chromatin ossification leukocyte homeostasis negative regulation of protein phosphorylation osteoblast fate commitment osteoblast development type B pancreatic cell differentiation DNA binding chromatin binding double-stranded DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol chromatin organization chromatin remodeling cellular response to DNA damage stimulus cell cycle arrest negative regulation of cell proliferation response to UV response to gamma radiation regulation of gene expression positive regulation of gene expression negative regulation of cell-substrate adhesion nuclear matrix histone methylation hemopoiesis positive regulation of transforming growth factor beta receptor signaling pathway protein binding, bridging positive regulation of histone methylation positive regulation of protein binding cleavage furrow regulation of activin receptor signaling pathway macromolecular complex histone lysine methylation histone methyltransferase complex positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of cell differentiation negative regulation of osteoblast differentiation positive regulation of osteoblast differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of organ growth protein N-terminus binding embryonic skeletal system morphogenesis negative regulation of epithelial cell proliferation positive regulation of cell division negative regulation of telomerase activity palate development maternal process involved in female pregnancy regulation of type B pancreatic cell proliferation R-SMAD binding response to transforming growth factor beta negative regulation of cell cycle G1/S phase transition histone-lysine N-methyltransferase activity uc289qle.1 uc289qle.2 
ENSMUST00000113515.8 Wdfy1 ENSMUST00000113515.8 Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436). (from UniProt E9Q4P1) AK165554 E9Q4P1 ENSMUST00000113515.1 ENSMUST00000113515.2 ENSMUST00000113515.3 ENSMUST00000113515.4 ENSMUST00000113515.5 ENSMUST00000113515.6 ENSMUST00000113515.7 Kiaa1435 Q5DTX9 WDFY1_MOUSE uc287jpj.1 uc287jpj.2 Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436). Binds PtdIns3P in vitro with high specificity over other phosphoinositides (By similarity). Interacts (via WD repeat 2) with tyrosine-phosphorylated TLR3 (via TIR domain) in response to poly(I:C) (PubMed:25736436). Interacts with TLR4 in response to LPS (PubMed:25736436). Interacts with TICAM1 in response to poly(I:C) (PubMed:25736436). Early endosome The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions. The FYVE domain is required for its function in regulating TLR3 signaling. Sequence=BAD90445.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding 1-phosphatidylinositol binding nucleus endosome early endosome cytosol positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway metal ion binding uc287jpj.1 uc287jpj.2 
ENSMUST00000113516.2 Kdr ENSMUST00000113516.2 kinase insert domain protein receptor, transcript variant 8 (from RefSeq NR_175358.1) C5H7S5 ENSMUST00000113516.1 Flk-1 Flk1 Kdr NR_175358 P35918 Q8VCD0 VGFR2_MOUSE uc008xul.1 uc008xul.2 uc008xul.3 uc008xul.4 uc008xul.5 Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as a negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and by preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence= Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. May be regulated by hydrogen sulfide (H(2)S) levels via a sensitive intracellular disulfide bond (By similarity). Homodimer in the presence of bound dimeric VEGFA, VEGFC or VEGFD ligands; monomeric in the absence of bound ligands. Can also form heterodimers with FLT1/VEGFR1 and KDR/VEGFR2. Interacts (tyrosine phosphorylated) with LFYN, NCK1, PLCG1. Interacts (tyrosine- phosphorylated active form preferentially) with DAB2IP (via C2 domain and active form preferentially); the interaction occurs at the late phase of VEGFA response and inhibits KDR/VEGFR2 activity. Interacts with SHBSH2D2A/TSAD, GRB2, MYOF, CBL and PDCD6 (PubMed:12796773, PubMed:12881528, PubMed:15026417, PubMed:15673613, PubMed:17702744, PubMed:19668192, PubMed:7681362, PubMed:8356051). Interacts (via C- terminus domain) with ERN1 (via kinase domain); the interaction is facilitated in a XBP1 isoform 1- and vascular endothelial growth factor (VEGF)-dependent manner in endothelial cells (By similarity). Interacts (via juxtamembrane region) with chaperone PDCL3 (via thioredoxin fold region); the interaction leads to increased KDR/VEGFR2 abundance through inhibition of its ubiquitination and degradation (By similarity). Interacts (tyrosine phosphorylated) with CCDC88A/GIV (via SH2-like region); binding requires autophosphorylation of the KDR/VEGFR2 C-terminal region (By similarity). Interacts with isoform 2 of BSG (By similarity). Interacts with SLC31A1; this interaction is induced upon VEGFA stimulation leading to SLC31A1 and KDR subsequent co-internalization to early endosomes, thereby activating KDR downstream signaling in endothelial cells (By similarity). P35918; P35917: Flt4; NbExp=3; IntAct=EBI-1555005, EBI-7845747; P35918; P16056: Met; NbExp=3; IntAct=EBI-1555005, EBI-1798780; P35918; P08581: MET; Xeno; NbExp=3; IntAct=EBI-1555005, EBI-1039152; P35918; P09619: PDGFRB; Xeno; NbExp=4; IntAct=EBI-1555005, EBI-641237; Cell junction doplasmic reticulum Cell membrane Note=Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (By similarity). Localized with RAP1A at cell-cell junctions. [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasm Nucleus Cytoplasmic vesicle Early endosome Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus (By similarity). [Isoform 2]: Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=mbVegfr-2; IsoId=P35918-1; Sequence=Displayed; Name=2; Synonyms=sVegfr-2; IsoId=P35918-2; Sequence=VSP_041986, VSP_041987; Expressed in endothelial cells (at protein level). Detected in embryonic endothelial cells, as well as hematopoietic stem and progenitor cells. Detected in vascular endothelium. Expressed at high levels in adult heart, lung, kidney, brain and skeletal muscle, but is also expressed at lower levels in most other adult tissues. Expressed in endothelial cells of allantois/umbilical vessels at 8.5 dpc (at protein level). Increases moderately during pregnancy (maximum 2.7-fold at 19 days), and increases further during lactation (maximum 3.7-fold increase on day 7). The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding. N-glycosylated. Ubiquitinated. Tyrosine phosphorylation of the receptor promotes its poly-ubiquitination, leading to its degradation via the proteasome or lysosomal proteases (By similarity). Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-949 is important for interaction with SH2D2A/TSAD and VEGFA-mediated reorganization of the actin cytoskeleton. Phosphorylation at Tyr-1173 is important for interaction with PLCG1 and SHB. Phosphorylation at Tyr-1212 is important for interaction with NCK1 and FYN. Dephosphorylated by PTPRJ at Tyr-799, Tyr-949, Tyr-994, Tyr-1052, Tyr-1057, Tyr-1173 and Tyr-1212 (By similarity). The inhibitory disulfide bond between Cys-1022 and Cys-1043 may serve as a specific molecular switch for H(2)S-induced modification that regulates KDR/VEGFR2 function. Embryonic lethality at 8.5 to 9.5 dpc, due to early defects in the development of hematopoietic and endothelial cells, leading to defects in vasculogenesis and endocardium development. At 7.5 dpc, there are no blood islands in the yolk sac. Organized blood vessels are absent in the yolk sac and in the embryo. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Sequence=CAA42040.1; Type=Frameshift; Evidence=; Sequence=CAA50192.1; Type=Frameshift; Evidence=; nucleotide binding angiogenesis ovarian follicle development vasculogenesis response to hypoxia positive regulation of protein phosphorylation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation lymph vessel development sprouting angiogenesis cell migration involved in sprouting angiogenesis positive regulation of mesenchymal cell proliferation endocardium development endothelium development endochondral bone growth protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity integrin binding protein binding ATP binding extracellular region nucleus cytoplasm endosome early endosome endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cytosolic calcium ion concentration multicellular organism development positive regulation of cell proliferation regulation of cell shape male gonad development external side of plasma membrane cell surface positive regulation of endothelial cell migration negative regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane positive regulation of macroautophagy kinase activity phosphorylation cell migration transferase activity peptidyl-tyrosine phosphorylation growth factor binding cell junction hemopoiesis cell differentiation lung development positive regulation of cell migration positive regulation of BMP signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway cytoplasmic vesicle positive regulation of TOR signaling embryonic hemopoiesis calcium-mediated signaling using intracellular calcium source cellular response to vascular endothelial growth factor stimulus positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway peptidyl-tyrosine autophosphorylation vascular endothelial growth factor binding response to drug identical protein binding neuron projection neuronal cell body negative regulation of apoptotic process surfactant homeostasis receptor complex positive regulation of MAPK cascade protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration membrane raft cell fate commitment cadherin binding endothelial cell differentiation positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway positive regulation of long-term neuronal synaptic plasticity lung alveolus development cell maturation post-embryonic camera-type eye morphogenesis branching morphogenesis of an epithelial tube neuron projection morphogenesis positive regulation of epithelial cell proliferation positive regulation of calcium-mediated signaling positive regulation of positive chemotaxis positive regulation of nitric-oxide synthase biosynthetic process positive regulation of focal adhesion assembly positive regulation of mitochondrial depolarization calcium ion homeostasis blood vessel endothelial cell differentiation ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cell periphery positive regulation of cell migration involved in sprouting angiogenesis positive regulation of mitochondrial fission sorting endosome regulation of hematopoietic progenitor cell differentiation regulation of bone development cellular response to hydrogen sulfide negative regulation of endothelial cell apoptotic process positive regulation of vasculogenesis uc008xul.1 uc008xul.2 uc008xul.3 uc008xul.4 uc008xul.5 
ENSMUST00000113520.8 Vegfa ENSMUST00000113520.8 vascular endothelial growth factor A, transcript variant 2 (from RefSeq NM_001317041.1) E9Q4N8 E9Q4N8_MOUSE ENSMUST00000113520.1 ENSMUST00000113520.2 ENSMUST00000113520.3 ENSMUST00000113520.4 ENSMUST00000113520.5 ENSMUST00000113520.6 ENSMUST00000113520.7 NM_001317041 Vegfa uc289ljz.1 uc289ljz.2 This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.[provided by RefSeq, Nov 2015]. Secreted Belongs to the PDGF/VEGF growth factor family. signal transduction growth factor activity heparin binding membrane uc289ljz.1 uc289ljz.2 
ENSMUST00000113523.9 Tmem63b ENSMUST00000113523.9 transmembrane protein 63b, transcript variant 1 (from RefSeq NM_198167.4) CSCL2_MOUSE ENSMUST00000113523.1 ENSMUST00000113523.2 ENSMUST00000113523.3 ENSMUST00000113523.4 ENSMUST00000113523.5 ENSMUST00000113523.6 ENSMUST00000113523.7 ENSMUST00000113523.8 NM_198167 Q3TWI9 Q6PCL2 Q6PGA4 Q8C1V5 Q8R0W7 uc012auh.1 uc012auh.2 uc012auh.3 Acts as an osmosensitive calcium-permeable cation channel (PubMed:27045885, PubMed:31243992). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (PubMed:30382938). Cell membrane ulti-pass membrane protein Belongs to the CSC1 (TC 1.A.17) family. Sequence=AAH57136.1; Type=Erroneous initiation; Evidence=; Sequence=AAH59283.1; Type=Erroneous initiation; Evidence=; calcium activated cation channel activity plasma membrane ion transport actin cytoskeleton membrane integral component of membrane ion transmembrane transport uc012auh.1 uc012auh.2 uc012auh.3 
ENSMUST00000113524.8 Mogat1 ENSMUST00000113524.8 Involved in glycerolipid synthesis and lipid metabolism (PubMed:12077311, PubMed:12621063). Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol, mainly at the sn- 1 or sn-3 positions (PubMed:12077311, PubMed:12621063). It uses both sn-2-monoacylglycerol (2-acylglycerol) and sn-1-monoacylglycerol (1- acyl-sn-glycerol) equally well as substrates, and uses sn-3- monoacylglycerol (3-acyl-sn-glycerol) with lower efficiency (PubMed:12077311). Probably not involved in absorption of dietary fat in the small intestine. (from UniProt Q91ZV4) BC106135 Dgat2l1 E9QLA2 ENSMUST00000113524.1 ENSMUST00000113524.2 ENSMUST00000113524.3 ENSMUST00000113524.4 ENSMUST00000113524.5 ENSMUST00000113524.6 ENSMUST00000113524.7 MOGT1_MOUSE Mogat1 Q91ZV4 Q9DCL0 uc287jop.1 uc287jop.2 Involved in glycerolipid synthesis and lipid metabolism (PubMed:12077311, PubMed:12621063). Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol, mainly at the sn- 1 or sn-3 positions (PubMed:12077311, PubMed:12621063). It uses both sn-2-monoacylglycerol (2-acylglycerol) and sn-1-monoacylglycerol (1- acyl-sn-glycerol) equally well as substrates, and uses sn-3- monoacylglycerol (3-acyl-sn-glycerol) with lower efficiency (PubMed:12077311). Probably not involved in absorption of dietary fat in the small intestine. Reaction=a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA; Xref=Rhea:RHEA:16741, ChEBI:CHEBI:17389, ChEBI:CHEBI:49172, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; EC=2.3.1.22; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16742; Evidence= Reaction=2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77271, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371, ChEBI:CHEBI:73990, ChEBI:CHEBI:197386; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77272; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77539, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:73990, ChEBI:CHEBI:197391; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77540; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl- 2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77275, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:73990, ChEBI:CHEBI:75579; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77276; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1- tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77279, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:73990, ChEBI:CHEBI:75582; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77280; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1- hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77283, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:73990, ChEBI:CHEBI:75585; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77284; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1- octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77287, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:73990, ChEBI:CHEBI:75590; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77288; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA = 1-eicosanoyl- 2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77543, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:73990, ChEBI:CHEBI:197392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77544; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:39951, ChEBI:CHEBI:52323, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:73990; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39952; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77291, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:73990, ChEBI:CHEBI:75614; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77292; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)- glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)- glycerol + CoA; Xref=Rhea:RHEA:77547, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:73990, ChEBI:CHEBI:75611; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77548; Evidence=; Reaction=a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA; Xref=Rhea:RHEA:32947, ChEBI:CHEBI:17389, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32948; Evidence=; Reaction=a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA; Xref=Rhea:RHEA:38467, ChEBI:CHEBI:17389, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:75524; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38468; Evidence=; Reaction=a 1-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA; Xref=Rhea:RHEA:39943, ChEBI:CHEBI:35759, ChEBI:CHEBI:49172, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39944; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-2- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38115, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75539, ChEBI:CHEBI:75579; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38116; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1- tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38119, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75562, ChEBI:CHEBI:75582; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38120; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1- hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38123, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:69081, ChEBI:CHEBI:75585; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38124; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:37915, ChEBI:CHEBI:52323, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37916; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75568, ChEBI:CHEBI:75614; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38132; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)- glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)- glycerol + CoA; Xref=Rhea:RHEA:38135, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75609, ChEBI:CHEBI:75610; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38136; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)- glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)- glycerol + CoA; Xref=Rhea:RHEA:38139, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75611, ChEBI:CHEBI:75612; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38140; Evidence=; Reaction=a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA; Xref=Rhea:RHEA:77571, ChEBI:CHEBI:35759, ChEBI:CHEBI:47777, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77572; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-3- (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77587, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75539, ChEBI:CHEBI:197406; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77588; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1-(9Z- octadecenoyl)-3-hexadecanoylglycerol + CoA; Xref=Rhea:RHEA:77563, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:69081, ChEBI:CHEBI:75869; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77564; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1- octadecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77583, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75555, ChEBI:CHEBI:197407; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77584; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycerol = 1,3- di-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:77267, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75735, ChEBI:CHEBI:75757; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77268; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol = 1-(9Z-octadecenoyl)-3-(9Z,12Z-octadecadienoyl)-glycerol + CoA; Xref=Rhea:RHEA:77591, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75568, ChEBI:CHEBI:133484; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77592; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)- glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-3-(9Z-octadecenoyl)- glycerol + CoA; Xref=Rhea:RHEA:77595, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75610, ChEBI:CHEBI:197408; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77596; Evidence=; Reaction=a 1-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA; Xref=Rhea:RHEA:77559, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64683, ChEBI:CHEBI:77272; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77560; Evidence=; Reaction=a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA; Xref=Rhea:RHEA:77555, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64760, ChEBI:CHEBI:77272; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77556; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 3-octadecanoyl-sn-glycerol = 1-(9Z- octadecenoyl)-3-octadecanoyl-sn-glycerol + CoA; Xref=Rhea:RHEA:77551, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75553, ChEBI:CHEBI:197404; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77552; Evidence=; Glycerolipid metabolism; triacylglycerol biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Expressed at high level in kidney and stomach. Expressed at lower level in brown and white adipose tissue, uterus and liver. Not detected in small intestine. Belongs to the diacylglycerol acyltransferase family. 2-acylglycerol O-acyltransferase activity diacylglycerol O-acyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane glycerol metabolic process lipid metabolic process diacylglycerol biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups triglyceride biosynthetic process uc287jop.1 uc287jop.2 
ENSMUST00000113528.2 Majin ENSMUST00000113528.2 membrane anchored junction protein, transcript variant 2 (from RefSeq NM_001377074.1) E9Q4N4 ENSMUST00000113528.1 MAJIN_MOUSE Majin NM_001377074 Q9D992 uc012bhj.1 uc012bhj.2 uc012bhj.3 Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. Component of the MAJIN-TERB1-TERB2 complex, composed of MAJIN, TERB1 and TERB2. Nucleus inner membrane ; Single-pass membrane protein Chromosome, telomere Note=Localizes to telomeres throughout meiotic prophase I and disappears in metaphase I. In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D992-1; Sequence=Displayed; Name=2; IsoId=Q9D992-2; Sequence=VSP_058064; Specifically expressed in germline tissues. Mice develop normally, exhibit no overt phenotype, but are infertile (both males and females). Gonads are characterized by the absence of post-meiotic cells. Impaired localization of Terb1 and Terb2 to the nucleus inner membrane. MAJIN was named after the 'genie in Aladdin's lamp' in Japanese. Belongs to the MAJIN family. chromosome, telomeric region nuclear chromosome, telomeric region molecular_function DNA binding nucleus nuclear inner membrane integral component of nuclear inner membrane chromosome synapsis membrane integral component of membrane meiotic telomere clustering meiotic cell cycle meiotic attachment of telomere to nuclear envelope uc012bhj.1 uc012bhj.2 uc012bhj.3 
ENSMUST00000113532.9 Hmcn2 ENSMUST00000113532.9 hemicentin 2 (from RefSeq NM_001370902.1) A2AJ76 ENSMUST00000113532.1 ENSMUST00000113532.2 ENSMUST00000113532.3 ENSMUST00000113532.4 ENSMUST00000113532.5 ENSMUST00000113532.6 ENSMUST00000113532.7 ENSMUST00000113532.8 HMCN2_MOUSE NM_001370902 Q8BNH3 uc289uwz.1 uc289uwz.2 Secreted, extracellular space, extracellular matrix Cleavage furrow Note=The antibody used in PubMed:17015624 and PubMed:21215633 to determine subcellular location does not distinguish between HMCN1 and HMCN2. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AJ76-1; Sequence=Displayed; Name=2; IsoId=A2AJ76-2; Sequence=VSP_039372; In neonatal skin, localized in the pericellular space of basal epidermal keratinocytes (at protein level) (PubMed:34504132). In adult skin, restricted to basal keratinocytes of hair follicles and the interfollicular epidermis (PubMed:34504132). Absent from the myotendinous junction but present in skeletal muscle (at protein level) (PubMed:34504132). Expressed in the pericellular extracellular matrix of epithelial cells in a number of tissues including embryonic trophectoderm and adult skin and tongue (PubMed:17015624). Also present in the extracellular matrix of some, but not all, blood vessels (PubMed:17015624). Expressed primarily in epithelial cells in the embryonic epidermis, lung, intestine, skeletal hindlimb muscle, tongue and the muscular layers of the esophagus (PubMed:34504132). Following wounding, up-regulated in the basal keratinocytes within the epidermal tongues of closing wounds. Reported to be phosphorylated; however as this position is extracellular, the in vivo relevance is unsure. Mutants are viable and fertile with no gross phenotypes (PubMed:32035013). Double knockout of Hmcn1 and Hmcn2 results in no overt phenotypes with mice being viable and fertile (PubMed:32035013). Sequence=BAC38997.1; Type=Frameshift; Evidence=; extracellular matrix structural constituent calcium ion binding extracellular region basement membrane extracellular space cell cortex cell junction extracellular matrix cleavage furrow response to stimulus uc289uwz.1 uc289uwz.2 
ENSMUST00000113533.3 Sac3d1 ENSMUST00000113533.3 SAC3 domain containing 1 (from RefSeq NM_133678.3) ENSMUST00000113533.1 ENSMUST00000113533.2 G5E8Q7 G5E8Q7_MOUSE NM_133678 Sac3d1 uc008ghl.1 uc008ghl.2 uc008ghl.3 uc008ghl.1 uc008ghl.2 uc008ghl.3 
ENSMUST00000113536.8 Fip1l1 ENSMUST00000113536.8 factor interacting with PAPOLA and CPSF1, transcript variant 4 (from RefSeq NM_001376964.1) ENSMUST00000113536.1 ENSMUST00000113536.2 ENSMUST00000113536.3 ENSMUST00000113536.4 ENSMUST00000113536.5 ENSMUST00000113536.6 ENSMUST00000113536.7 FIP1_MOUSE NM_001376964 Q8BWX7 Q99LH0 Q9D824 Q9DBB2 uc008xto.1 uc008xto.2 uc008xto.3 uc008xto.4 Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity). Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with CPSF1, CPSF4, CSTF2 and CSTF3 (By similarity). Interacts with AHCYL1 (when phosphorylated); the interaction is direct and associates AHCYL1 with the CPSF complex and RNA (PubMed:19224921). Interacts with PAPOLA; the interaction seems to be increased by the interaction with AHCYL1 (PubMed:19224921). Interacts with NUDT21/CPSF5; this interaction occurs in a RNA sequence-specific manner. Interacts (preferentially via unphosphorylated form and Arg/Glu/Asp-rich domain) with CPSF6 (via Arg/Ser-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF6 hyper-phosphorylation. Interacts (preferentially via unphosphorylated form and Arg/Asp/Glu-rich domain) with CPSF7 (via Arg/Ser-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF7 hyper-phosphorylation (By similarity). Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9D824-1; Sequence=Displayed; Name=2; IsoId=Q9D824-2; Sequence=VSP_016734; Name=3; IsoId=Q9D824-3; Sequence=VSP_016734, VSP_016735; Name=4; IsoId=Q9D824-4; Sequence=VSP_016733, VSP_016735, VSP_016736; Belongs to the FIP1 family. RNA binding protein binding nucleus mRNA cleavage and polyadenylation specificity factor complex mRNA polyadenylation mRNA processing pre-mRNA cleavage required for polyadenylation uc008xto.1 uc008xto.2 uc008xto.3 uc008xto.4 
ENSMUST00000113547.2 Tcte1 ENSMUST00000113547.2 t-complex-associated testis expressed 1 (from RefSeq NM_013688.2) A6H639 D17sil1 DRC5_MOUSE Drc5 ENSMUST00000113547.1 NM_013688 Q62294 uc008cqt.1 uc008cqt.2 uc008cqt.3 Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC (By similarity). Required for sperm motility (PubMed:28630322). Component of the nexin-dynein regulatory complex (N-DRC). Interacts with DRC1 (By similarity). Interacts with FBXL13/DRC6, DRC3 and DRC7 (PubMed:28630322, PubMed:31961863). Cell projection, cilium, flagellum Cytoplasm, cytoskeleton, flagellum axoneme Note=Detected along the length of the sperm flagellum. Testis-specific (at protein level). Male mice are sterile due to asthenozoospermia (sperm with diminished progressive motility) and the diminished motility is due to aberrant flagellar function, with sperm tails contracting toward one side and generating a circular path for sperm. Belongs to the DRC5 family. Sequence=AAA40406.1; Type=Frameshift; Evidence=; protein binding cytoplasm cytoskeleton cilium flagellated sperm motility motile cilium sperm flagellum cell projection uc008cqt.1 uc008cqt.2 uc008cqt.3 
ENSMUST00000113557.8 Atp7a ENSMUST00000113557.8 ATPase, Cu++ transporting, alpha polypeptide, transcript variant 2 (from RefSeq NM_009726.5) A2AG69 ATP7A_MOUSE Atp7a ENSMUST00000113557.1 ENSMUST00000113557.2 ENSMUST00000113557.3 ENSMUST00000113557.4 ENSMUST00000113557.5 ENSMUST00000113557.6 ENSMUST00000113557.7 Mnk NM_009726 O35101 P97422 Q64430 Q64431 uc012hnn.1 uc012hnn.2 uc012hnn.3 uc012hnn.4 ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:25639447, PubMed:27337370, PubMed:18650808). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:27337370, PubMed:18650808, PubMed:16371425, PubMed:12488345). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (By similarity). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (PubMed:25639447, PubMed:15634787, PubMed:16371425, PubMed:12488345). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (PubMed:18650808). Reaction=ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:25792, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:49552, ChEBI:CHEBI:456216; EC=7.2.2.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25793; Evidence=; Monomer. Interacts with PDZD11. Interacts with ATOX1 and COMMD1 (By similarity). Interacts with TYRP1 (PubMed:18650808). Directly interacts with SOD3; this interaction is copper-dependent and is required for SOD3 activity (PubMed:16371425). Golgi apparatus, trans-Golgi network membrane ulti-pass membrane protein Cell membrane ; Multi-pass membrane protein Melanosome membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Cell projection, axon Cell projection, dendrite Postsynaptic density Note=Cycles constitutively between the TGN and the plasma membrane. Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels (PubMed:27337370). Targeting into melanosomes is regulated by BLOC-1 complex (PubMed:18650808). In response to glutamate translocates to neuron processes with a minor fraction at extrasynaptic sites (By similarity). Widely expressed (PubMed:25639447, PubMed:8054976, PubMed:12488345). Highly expressed in pituitary endocrine cells (PubMed:12488345). Expressed in melanocytes (at protein level) (PubMed:18650808). Expressed in motor neuron (at protein level) (PubMed:25639447). Expressed in hippocampal neuron (at protein level) (PubMed:15634787). In the kidney, it is detected in the proximal and distal tubules (at protein level) (PubMed:9215672). Expressed in aorta (at protein level) (PubMed:16371425). Detected 10 days after birth in pituitary and adrenal endocrine tissues and at a lower level in hypothalamus and atrium (at protein level). The ATP binding site comprises residues located in alpha-1 and alpha-2 helices and beta-2 and beta-3 strands, which are involved in van der Waal's interactions, and Glu-1072 which forms an hydrogen bond with the adenine ring. The heavy-metal-associated domain (HMA) coordinates a Cu(+) ion via the cysteine residues within the CXXC motif. The transfer of Cu(+) ion from ATOX1 to ATP7A involves the formation of a three-coordinate Cu(+)-bridged heterodimer where the metal is shared between the two metal binding sites of ATOX1 and ATP7A. The Cu(+) ion appears to switch between two coordination modes, forming two links with one protein and one with the other. Cisplatin, a chemotherapeutic drug, can bind the CXXC motif and hinder the release of Cu(+) ion. Contains three di-leucine motifs in the C-terminus which are required for recycling from the plasma membrane to the TGN. The di- leucine 1478-Leu-Leu-1479 motif mediates endocytosis at the plasma membrane, whereas the di-leucine 1458-Leu-Leu-1459 motif is a sorting signal for retrograde trafficking to TGN via early endosomes. Note=Defects in Atp7a are associated with mottled, an X-linked recessive condition characterized by mottled pigmentation of the coat, defects in connective tissue and neonatal or fetal death. It is due to a defect in absorption and transport of copper. The mottled mutants exhibit a diversity of phenotypes. Two of these mutants are called brindled and blotchy and their phenotypes resemble classical Menkes disease (MD) and occipital horn syndrome (OHS) in humans, respectively. Other mutants are called dappled, mosaic, tortoiseshell, pewter, etc. Cell-specific silencing in motor neurons is associated with loss of motor neuron cell bodies and progressive denervation of the neuromuscular junctions with aging, consistent with the clinical features of human distal spinal muscular atrophy X-linked disease, 3 (DSMAX3). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. Name=Protein Spotlight; Note=Heavy metal - Issue 79 of February 2007; URL="https://web.expasy.org/spotlight/back_issues/079"; nucleotide binding blood vessel development release of cytochrome c from mitochondria blood vessel remodeling regulation of oxidative phosphorylation copper ion transmembrane transporter activity copper ion binding protein binding ATP binding nucleus late endosome endoplasmic reticulum Golgi apparatus trans-Golgi network cytosol plasma membrane microvillus tryptophan metabolic process tyrosine metabolic process catecholamine metabolic process ion transport cation transport copper ion transport cellular copper ion homeostasis mitochondrion organization locomotory behavior response to manganese ion detoxification of copper ion regulation of gene expression positive regulation of lamellipodium assembly copper ion import membrane integral component of membrane basolateral plasma membrane apical plasma membrane superoxide dismutase copper chaperone activity peptidyl-lysine modification removal of superoxide radicals cation-transporting ATPase activity cerebellar Purkinje cell differentiation pyramidal neuron development central nervous system neuron development metal ion transport trans-Golgi network transport vesicle secretory granule extracellular matrix organization collagen fibril organization hair follicle morphogenesis cell leading edge cytoplasmic vesicle brush border membrane copper-dependent protein binding negative regulation of iron ion transmembrane transport cellular response to platelet-derived growth factor stimulus T-helper cell differentiation epinephrine metabolic process norepinephrine metabolic process dopamine metabolic process norepinephrine biosynthetic process serotonin metabolic process neuron projection neuronal cell body positive regulation of catalytic activity negative regulation of catalytic activity perikaryon pigmentation negative regulation of neuron apoptotic process skin development copper-transporting ATPase activity membrane raft positive regulation of cell size ATP metabolic process response to copper ion metal ion binding elastic fiber assembly lung alveolus development Rac GTPase binding perinuclear region of cytoplasm neuron projection morphogenesis dendrite morphogenesis positive regulation of epithelial cell proliferation chaperone binding cartilage development positive regulation of oxidoreductase activity elastin biosynthetic process copper ion export cellular response to amino acid stimulus cellular response to copper ion divalent inorganic cation transport positive regulation of response to wounding cuprous ion binding positive regulation of vascular associated smooth muscle cell migration regulation of cytochrome-c oxidase activity uc012hnn.1 uc012hnn.2 uc012hnn.3 uc012hnn.4 
ENSMUST00000113562.9 Fnbp1 ENSMUST00000113562.9 formin binding protein 1, transcript variant 1 (from RefSeq NM_001038700.2) A2AQ40 A2AQ46 ENSMUST00000113562.1 ENSMUST00000113562.2 ENSMUST00000113562.3 ENSMUST00000113562.4 ENSMUST00000113562.5 ENSMUST00000113562.6 ENSMUST00000113562.7 ENSMUST00000113562.8 FNBP1_MOUSE Fbp17 Kiaa0554 NM_001038700 Q3TA45 Q3TCW9 Q3U081 Q3UPI7 Q80TY0 Q8C727 Q99L37 uc008jdi.1 uc008jdi.2 uc008jdi.3 uc008jdi.4 Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the actin cytoskeleton. May be required for the lysosomal retention of FASLG/FASL (By similarity). Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures. Interacts specifically with GTP-bound RND2 and CDC42. Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, DNM2, DNM3, FASLG/FASL, microtubules, PDE6G, SNX2 and WASL/N-WASP. May interact with TNKS (By similarity). Cytoplasm Cytoplasm, cytoskeleton Cytoplasm, cell cortex Lysosome Cytoplasmic vesicle Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane, clathrin-coated pit Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q80TY0-1; Sequence=Displayed; Name=2; IsoId=Q80TY0-2; Sequence=VSP_021698; Name=3; IsoId=Q80TY0-3; Sequence=VSP_021698, VSP_021703; Name=4; IsoId=Q80TY0-4; Sequence=VSP_021697, VSP_021699, VSP_021702; Name=5; IsoId=Q80TY0-5; Sequence=VSP_021700, VSP_021701; Expressed in brain and testis. The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity). Belongs to the FNBP1 family. Sequence=BAC65590.1; Type=Erroneous initiation; Evidence=; Sequence=BAE33974.1; Type=Erroneous initiation; Evidence=; cytoplasm lysosome cytoskeleton plasma membrane clathrin-coated pit cell cortex endocytosis nervous system development lipid binding membrane cytoplasmic vesicle identical protein binding uc008jdi.1 uc008jdi.2 uc008jdi.3 uc008jdi.4 
ENSMUST00000113567.10 Obsl1 ENSMUST00000113567.10 obscurin-like 1, transcript variant 5 (from RefSeq NR_175351.1) A0A803ZIZ6 A0A803ZIZ6_MOUSE ENSMUST00000113567.1 ENSMUST00000113567.2 ENSMUST00000113567.3 ENSMUST00000113567.4 ENSMUST00000113567.5 ENSMUST00000113567.6 ENSMUST00000113567.7 ENSMUST00000113567.8 ENSMUST00000113567.9 NR_175351 Obsl1 uc007bpn.1 uc007bpn.2 uc007bpn.3 uc007bpn.4 uc007bpn.1 uc007bpn.2 uc007bpn.3 uc007bpn.4 
ENSMUST00000113570.8 Aqp9 ENSMUST00000113570.8 Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines. (from UniProt Q9JJJ3) AK050325 AQP9_MOUSE ENSMUST00000113570.1 ENSMUST00000113570.2 ENSMUST00000113570.3 ENSMUST00000113570.4 ENSMUST00000113570.5 ENSMUST00000113570.6 ENSMUST00000113570.7 Q9JJJ3 uc292imy.1 uc292imy.2 Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines. Cell membrane ; Multi-pass membrane protein Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Belongs to the MIP/aquaporin (TC 1.A.8) family. purine nucleobase transmembrane transporter activity pyrimidine nucleobase transmembrane transporter activity plasma membrane integral component of plasma membrane water transport purine nucleobase transport response to organic substance urea transmembrane transporter activity water channel activity glycerol channel activity urea channel activity channel activity canalicular bile acid transport polyol transport glycerol transport amine transport pyrimidine nucleobase transport membrane integral component of membrane basolateral plasma membrane intracellular membrane-bounded organelle response to mercury ion transmembrane transport urea transmembrane transport pyrimidine-containing compound transmembrane transport purine nucleobase transmembrane transport uc292imy.1 uc292imy.2 
ENSMUST00000113571.10 Runx2 ENSMUST00000113571.10 runt related transcription factor 2, transcript variant 3 (from RefSeq NM_009820.6) Aml3 Cbfa1 ENSMUST00000113571.1 ENSMUST00000113571.2 ENSMUST00000113571.3 ENSMUST00000113571.4 ENSMUST00000113571.5 ENSMUST00000113571.6 ENSMUST00000113571.7 ENSMUST00000113571.8 ENSMUST00000113571.9 NM_009820 O35183 Osf2 Pebp2a Q08775 Q08776 Q9JLN0 Q9QUQ6 Q9QY29 Q9R0U4 Q9Z2J7 RUNX2_MOUSE uc008cqi.1 uc008cqi.2 uc008cqi.3 uc008cqi.4 uc008cqi.5 This gene encodes a member of the runt domain-containing family of transcription factors. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Sep 2015]. Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2- mediated activation of the osteocalcin FGF-responsive element (OCFRE). Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with CCNB1, KAT6A and KAT6B (By similarity). Interacts with HIVEP3. Interacts with IFI204. Interaction with SATB2; the interaction results in enhanced DNA binding and transactivation by these transcription factors. Binds to HIPK3. Interacts with FOXO1 (via a C-terminal region); the interaction inhibits RUNX2 transcriptional activity towards BGLAP. Interacts with FOXP3 (By similarity). Interacts with TMEM119 (PubMed:21239498). Interacts with OLFM2 (By similarity). Interacts with IPO7; the interaction inhibits RUNX2 nuclear translocation in osteoblasts (PubMed:35922041). [Isoform 3]: Interacts with DDX5. Q08775; Q6NZM9: Hdac4; NbExp=3; IntAct=EBI-903354, EBI-646397; Q08775; Q9D030: Twist2; NbExp=2; IntAct=EBI-903354, EBI-2903190; Q08775; P25976: Ubtf; NbExp=4; IntAct=EBI-903354, EBI-7364139; Q08775; Q6AYI1: Ddx5; Xeno; NbExp=2; IntAct=EBI-903354, EBI-931635; Q08775-3; P17844: DDX5; Xeno; NbExp=2; IntAct=EBI-6119991, EBI-351962; Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=9; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q08775-1; Sequence=Displayed; Name=2; IsoId=Q08775-2; Sequence=VSP_005941; Name=3; Synonyms=PEBP2-alpha A1; IsoId=Q08775-3; Sequence=VSP_005940, VSP_005942; Name=4; Synonyms=PEBP2-alpha A2; IsoId=Q08775-4; Sequence=VSP_005940, VSP_005942, VSP_005944, VSP_005945; Name=5; Synonyms=G1; IsoId=Q08775-5; Sequence=VSP_005939; Name=6; Synonyms=G2; IsoId=Q08775-6; Sequence=VSP_005939, VSP_005943; Name=7; Synonyms=U1; IsoId=Q08775-7; Sequence=VSP_005939, VSP_005946, VSP_005948; Name=8; Synonyms=Y1; IsoId=Q08775-8; Sequence=VSP_005939, VSP_005947; Name=9; Synonyms=Y2; IsoId=Q08775-9; Sequence=VSP_005939, VSP_005943, VSP_005947; Found in thymus and testis, T-cell lines but not in B-cell lines. Isoform 2 is exclusively found in bone, particularly in osteoblasts; isoforms 3 and 4 are expressed in T-cell lines; isoforms 5, 6, 7, 8 and 9 can be found in osteoblasts and osteosarcoma cell lines. Expressed in early bell stage dental mesenchymal cells at 15.5 dpc (at protein level) (PubMed:24028588). Expressed in bell stage dental mesenchymal cells at 17.5 dpc (PubMed:29148101). [Isoform 2]: Expression occurs early during skeletal development and is restricted to cells of the mesenchymal condensations and of the osteoblast lineage at 12.5 dpc. Induced during the early stages of odontoblastic differentiation in dental papilla cells (PubMed:35922041). Induced during osteoblastic differentiation (PubMed:35922041). A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes and contains the phosphorylation sites. Phosphorylated; probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2 transactivation during osteoblastic differentiation. Phosphorylation at Ser-537 by CDK1 promotes endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression (By similarity). nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development osteoblast differentiation endochondral ossification osteoblast fate commitment chondrocyte differentiation chondrocyte development osteoblast development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding ATP binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol regulation of transcription, DNA-templated transcription factor binding positive regulation of cell proliferation regulation of gene expression positive regulation of gene expression protein domain specific binding hemopoiesis cell differentiation neuron differentiation T cell differentiation regulation of ossification BMP signaling pathway positive regulation of chondrocyte differentiation macromolecular complex embryonic forelimb morphogenesis regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth regulation of odontogenesis of dentin-containing tooth histone deacetylase binding bHLH transcription factor binding transcription regulatory region DNA binding regulation of osteoblast differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell maturation embryonic cranial skeleton morphogenesis skeletal system morphogenesis stem cell differentiation repressing transcription factor binding cellular response to BMP stimulus positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus uc008cqi.1 uc008cqi.2 uc008cqi.3 uc008cqi.4 uc008cqi.5 
ENSMUST00000113573.8 Atrx ENSMUST00000113573.8 ATRX, chromatin remodeler (from RefSeq NM_009530.2) A2ADH4 ATRX_MOUSE ENSMUST00000113573.1 ENSMUST00000113573.2 ENSMUST00000113573.3 ENSMUST00000113573.4 ENSMUST00000113573.5 ENSMUST00000113573.6 ENSMUST00000113573.7 Hp1bp2 NM_009530 Q61687 Xnp uc009ubb.1 uc009ubb.2 uc009ubb.3 uc009ubb.4 Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells probably implying recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according (PubMed:20211137) is required for its transcriptional repression in embryonic stem cells. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc- finger genes (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Interacts with DAXX to form the chromatin remodeling complex ATRX:DAXX. Probably binds EZH2. Binds annexin V in a calcium and phosphatidylcholine/phosphatidylserine-dependent manner. Interacts directly with CBX5 via the PxVxL motif. Interacts with RAD50, MRE11 and NBN; indicative for an association with the MRN complex. Interacts with histone MACROH2A1. Interacts with histone H3 peptides methylated at 'Lys-10' with preferences H3K9me3 > H3K9me2 > H3K9me1. Interacts with histone H3 peptides unmethylated at 'Lys-5' (H3K4me0). Interacts with MECP2, SMC1 and SMC3. Interacts with SETDB1, TRIM28 and ZNF274 (By similarity). Q61687; Q9Z2D6: Mecp2; NbExp=5; IntAct=EBI-2657527, EBI-1188816; Q61687; Q9CU62: Smc1a; NbExp=4; IntAct=EBI-2657527, EBI-2550016; Nucleus. Chromosome, telomere. Nucleus, PML body Note=Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with CBX5/HP1 alpha. Colocalizes with histone H3.3, DAXX, HIRA and ASF1A at PML- nuclear bodies (By similarity). In embryonic stem cells localized to telomeres; localization is reduced after 12 d of induction of cell differentiation. Colocalizes with cohesin (SMC1 and SMC3) and MECP2 at the maternal H19 ICR and the Gtl2/Dlk1 imprinted cluster in the brain. The ADD domain predominantly interacts with histone H3 trimethylated at 'Lys-10'(H3K9me3) (and to a lesser extent H3 mono- or dimethylated at 'Lys-10') and simultanously to histone H3 unmethylated at 'Lys-5' (H3K4me0). The interaction with H3K9me3 is disrupted by the presence of H3K4me3 suggesting a readout of the combined histone H3 methylation state (By similarity). Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain. Citrullinated by PADI4. Belongs to the SNF2/RAD54 helicase family. nucleotide binding meiotic spindle organization nuclear chromosome condensed nuclear chromosome, centromeric region chromosome, telomeric region nuclear chromosome, telomeric region heterochromatin DNA binding DNA helicase activity chromatin binding helicase activity protein binding ATP binding nucleus nucleoplasm chromosome pericentric heterochromatin cytoplasm DNA repair chromatin organization nucleosome assembly DNA replication-independent nucleosome assembly chromatin remodeling cellular response to DNA damage stimulus spermatogenesis positive regulation of nuclear cell cycle DNA replication DNA translocase activity nuclear body PML body hydrolase activity DNA damage response, signal transduction by p53 class mediator forebrain development replication fork processing nuclear pericentric heterochromatin telomeric heterochromatin positive regulation of telomere maintenance DNA duplex unwinding methylated histone binding post-embryonic forelimb morphogenesis multicellular organism growth histone binding positive regulation of transcription from RNA polymerase II promoter metal ion binding Sertoli cell development chromo shadow domain binding chromosome organization involved in meiotic cell cycle protein localization to chromosome, telomeric region seminiferous tubule development cellular response to hydroxyurea regulation of histone H3-K9 trimethylation negative regulation of telomeric RNA transcription from RNA pol II promoter positive regulation of telomeric RNA transcription from RNA pol II promoter negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric nuclear subtelomeric heterochromatin uc009ubb.1 uc009ubb.2 uc009ubb.3 uc009ubb.4 
ENSMUST00000113575.9 Tmem198 ENSMUST00000113575.9 transmembrane protein 198 (from RefSeq NM_177056.4) ENSMUST00000113575.1 ENSMUST00000113575.2 ENSMUST00000113575.3 ENSMUST00000113575.4 ENSMUST00000113575.5 ENSMUST00000113575.6 ENSMUST00000113575.7 ENSMUST00000113575.8 NM_177056 Q8BG75 TM198_MOUSE uc007bpl.1 uc007bpl.2 uc007bpl.3 Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity (By similarity). Interacts with LRP6. Membrane ; Multi-pass membrane protein Cell membrane Cytoplasmic vesicle Note=Largely located to vesicle-like structures. Belongs to the TMEM198 family. molecular_function plasma membrane multicellular organism development membrane integral component of membrane Wnt signaling pathway cytoplasmic vesicle positive regulation of canonical Wnt signaling pathway uc007bpl.1 uc007bpl.2 uc007bpl.3 
ENSMUST00000113585.9 Mgll ENSMUST00000113585.9 monoglyceride lipase, transcript variant 2 (from RefSeq NM_011844.5) ENSMUST00000113585.1 ENSMUST00000113585.2 ENSMUST00000113585.3 ENSMUST00000113585.4 ENSMUST00000113585.5 ENSMUST00000113585.6 ENSMUST00000113585.7 ENSMUST00000113585.8 MGLL_MOUSE Mgll NM_011844 O35678 Q3V2R0 Q9D9G8 uc009cvp.1 uc009cvp.2 uc009cvp.3 This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol. This enzyme is also thought to hydrolyze the endocannabinoid 2-arachidonoylglycerol. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]. Converts monoacylglycerides to free fatty acids and glycerol (PubMed:9341166, PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:9341166, PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity). Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.; EC=3.1.1.23; Evidence= Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26133; Evidence=; Reaction=1-octanoylglycerol + H2O = glycerol + H(+) + octanoate; Xref=Rhea:RHEA:44328, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:25646, ChEBI:CHEBI:85241; Evidence=; Reaction=1-decanoylglycerol + H2O = decanoate + glycerol + H(+); Xref=Rhea:RHEA:44320, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:27689, ChEBI:CHEBI:75547; Evidence=; Reaction=1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+); Xref=Rhea:RHEA:44316, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:18262, ChEBI:CHEBI:75539; Evidence=; Reaction=1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate; Xref=Rhea:RHEA:44312, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30807, ChEBI:CHEBI:75562; Evidence=; Reaction=2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:39963, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:75455; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39964; Evidence=; Reaction=1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38488; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38491, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:73990; Evidence=; Reaction=2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)- octadecadienoate + glycerol + H(+); Xref=Rhea:RHEA:44732, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30245, ChEBI:CHEBI:75457; Evidence=; Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:44728, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:75612; Evidence=; Reaction=1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)- octadecadienoate + glycerol + H(+); Xref=Rhea:RHEA:48428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30245, ChEBI:CHEBI:75568; Evidence=; Reaction=(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:39955, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75937; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39956; Evidence=; Reaction=1-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:39959, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:69081; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39960; Evidence=; Reaction=1-octadecanoylglycerol + H2O = glycerol + H(+) + octadecanoate; Xref=Rhea:RHEA:38363, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:25629, ChEBI:CHEBI:75555; Evidence=; Reaction=H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2; Xref=Rhea:RHEA:48296, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:90230, ChEBI:CHEBI:606564; Evidence=; Reaction=H2O + prostaglandin D2-1-glycerol ester = glycerol + H(+) + prostaglandin D2; Xref=Rhea:RHEA:45412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:57406, ChEBI:CHEBI:85232; Evidence=; Reaction=11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O = 15-deoxy- Delta(12,14)-prostaglandin J2 + glycerol + H(+); Xref=Rhea:RHEA:45416, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:85236, ChEBI:CHEBI:85238; Evidence=; Reaction=H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha; Xref=Rhea:RHEA:48300, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:57404, ChEBI:CHEBI:90233; Evidence=; Glycerolipid metabolism; triacylglycerol degradation. Homodimer. Cytoplasm, cytosol Membrane; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O35678-1; Sequence=Displayed; Name=2; IsoId=O35678-2; Sequence=VSP_010315; Ubiquitous. Mice display a reduction in monoglyceride hydrolase activity and a concomitant increase in monoglyceride levels in adipose tissue, brain, and liver (PubMed:20554061). Ten-fold increase in brain 2-arachidonoylglycerol levels, combined with low levels of brain arachidonic acid (PubMed:20554061, PubMed:20729846). Short-term inhibition causes analgesia, while long-term inhibition causes tolerance to endocannabinoids acting on brain cannabinoid receptor CNR1, and a reduction in brain cannabinoid receptor CNR1 activity. Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family. nucleoplasm cytoplasm cytosol lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process regulation of signal transduction membrane lipid catabolic process hydrolase activity arachidonic acid metabolic process triglyceride catabolic process extrinsic component of membrane axon regulation of axon extension protein homodimerization activity varicosity synapse acylglycerol catabolic process acylglycerol lipase activity regulation of inflammatory response regulation of sensory perception of pain monoacylglycerol catabolic process carboxylic ester hydrolase activity long term synaptic depression regulation of endocannabinoid signaling pathway uc009cvp.1 uc009cvp.2 uc009cvp.3 
ENSMUST00000113594.8 Tec ENSMUST00000113594.8 tec protein tyrosine kinase, transcript variant 2 (from RefSeq NM_001113464.2) ENSMUST00000113594.1 ENSMUST00000113594.2 ENSMUST00000113594.3 ENSMUST00000113594.4 ENSMUST00000113594.5 ENSMUST00000113594.6 ENSMUST00000113594.7 NM_001113464 Q3U436 Q3U436_MOUSE Tec uc008xse.1 uc008xse.2 uc008xse.3 uc008xse.4 uc008xse.5 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Cytoplasm Belongs to the protein kinase superfamily. Tyr protein kinase family. nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity ATP binding cytoskeleton plasma membrane protein phosphorylation integrin-mediated signaling pathway regulation of platelet activation kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation intracellular signal transduction peptidyl-tyrosine autophosphorylation tissue regeneration positive regulation of peptidyl-tyrosine phosphorylation B cell receptor signaling pathway uc008xse.1 uc008xse.2 uc008xse.3 uc008xse.4 uc008xse.5 
ENSMUST00000113600.10 Rab7 ENSMUST00000113600.10 RAB7, member RAS oncogene family, transcript variant 2 (from RefSeq NM_009005.3) ENSMUST00000113600.1 ENSMUST00000113600.2 ENSMUST00000113600.3 ENSMUST00000113600.4 ENSMUST00000113600.5 ENSMUST00000113600.6 ENSMUST00000113600.7 ENSMUST00000113600.8 ENSMUST00000113600.9 NM_009005 Q4FJQ0 Q4FJQ0_MOUSE Rab7 uc009cuz.1 uc009cuz.2 uc009cuz.3 Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Cytoplasmic vesicle, autophagosome membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, phagosome membrane ; Peripheral membrane protein ; Cytoplasmic side Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Melanosome membrane ; Peripheral membrane protein ; Cytoplasmic side Mitochondrion membrane ; Peripheral membrane protein Belongs to the small GTPase superfamily. Rab family. autophagosome assembly GTPase activity GTP binding lysosome late endosome cytosol protein targeting to lysosome epidermal growth factor catabolic process endosome to lysosome transport endosome membrane GDP binding viral release from host cell protein to membrane docking retromer complex cytoplasmic vesicle retrograde transport, endosome to Golgi early endosome to late endosome transport phagocytic vesicle bone resorption positive regulation of protein catabolic process Rac GTPase binding positive regulation of viral process phagosome acidification phagosome-lysosome fusion alveolar lamellar body anchored component of synaptic vesicle membrane negative regulation of exosomal secretion positive regulation of exosomal secretion retromer complex binding uc009cuz.1 uc009cuz.2 uc009cuz.3 
ENSMUST00000113602.2 Fam236e ENSMUST00000113602.2 family with sequence similarity 236, member E (from RefSeq NR_073044.1) 1700011M02Rik B1AX35 B1AX35_MOUSE ENSMUST00000113602.1 Fam236e Gm9112 NR_073044 uc009tzf.1 uc009tzf.2 molecular_function cellular_component biological_process uc009tzf.1 uc009tzf.2 
ENSMUST00000113607.10 Copg1 ENSMUST00000113607.10 coatomer protein complex, subunit gamma 1, transcript variant 1 (from RefSeq NM_017477.2) COPG1_MOUSE Copg ENSMUST00000113607.1 ENSMUST00000113607.2 ENSMUST00000113607.3 ENSMUST00000113607.4 ENSMUST00000113607.5 ENSMUST00000113607.6 ENSMUST00000113607.7 ENSMUST00000113607.8 ENSMUST00000113607.9 NM_017477 Q3U9F4 Q8BP96 Q8R1A7 Q922C6 Q9QZE5 uc009cug.1 uc009cug.2 uc009cug.3 uc009cug.4 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis. Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with ZNF289/ARFGAP2 through its C-terminal appendage domain (By similarity). Interacts with EGFR upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER (By similarity). Interacts with COPB1 (By similarity). Interacts with TMED10 (via C-terminus). Interacts with TMED2, TMED3, TMED7 and TMED9 (By similarity). Cytoplasm, cytosol Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Predominantly located in the cis- Golgi apparatus. Belongs to the COPG family. Sequence=BAC36811.1; Type=Frameshift; Evidence=; Golgi membrane structural molecule activity cytoplasm endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cytosol intracellular protein transport ER to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport protein secretion protein transport membrane vesicle-mediated transport membrane coat COPI vesicle coat COPI-coated vesicle membrane cytoplasmic vesicle establishment of Golgi localization organelle transport along microtubule uc009cug.1 uc009cug.2 uc009cug.3 uc009cug.4 
ENSMUST00000113610.3 Fam236f ENSMUST00000113610.3 family with sequence similarity 236, member F (from RefSeq NM_001177365.1) A2AI92 A2AI92_MOUSE ENSMUST00000113610.1 ENSMUST00000113610.2 Fam236f Gm9112 NM_001177365 uc012hnb.1 uc012hnb.2 uc012hnb.3 molecular_function cellular_component biological_process uc012hnb.1 uc012hnb.2 uc012hnb.3 
ENSMUST00000113615.9 Pcnx3 ENSMUST00000113615.9 pecanex homolog 3 (from RefSeq NM_144868.3) ENSMUST00000113615.1 ENSMUST00000113615.2 ENSMUST00000113615.3 ENSMUST00000113615.4 ENSMUST00000113615.5 ENSMUST00000113615.6 ENSMUST00000113615.7 ENSMUST00000113615.8 NM_144868 PCX3_MOUSE Pcnx3 Pcnxl3 Q8VI59 uc008geq.1 uc008geq.2 uc008geq.3 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VI59-1; Sequence=Displayed; Name=2; IsoId=Q8VI59-2; Sequence=VSP_033246; Belongs to the pecanex family. molecular_function cellular_component biological_process membrane integral component of membrane uc008geq.1 uc008geq.2 uc008geq.3 
ENSMUST00000113621.10 Sh3glb2 ENSMUST00000113621.10 SH3-domain GRB2-like endophilin B2, transcript variant 4 (from RefSeq NM_001346806.2) A2AWI7 A2AWI7_MOUSE ENSMUST00000113621.1 ENSMUST00000113621.2 ENSMUST00000113621.3 ENSMUST00000113621.4 ENSMUST00000113621.5 ENSMUST00000113621.6 ENSMUST00000113621.7 ENSMUST00000113621.8 ENSMUST00000113621.9 NM_001346806 Sh3glb2 uc057lch.1 uc057lch.2 uc057lch.3 Homodimer, and heterodimer with SH3GLB1. Cytoplasm Belongs to the endophilin family. nucleoplasm cytoplasm cytosol identical protein binding uc057lch.1 uc057lch.2 uc057lch.3 
ENSMUST00000113623.8 Glb1l ENSMUST00000113623.8 galactosidase, beta 1-like (from RefSeq NM_029010.2) ENSMUST00000113623.1 ENSMUST00000113623.2 ENSMUST00000113623.3 ENSMUST00000113623.4 ENSMUST00000113623.5 ENSMUST00000113623.6 ENSMUST00000113623.7 GLB1L_MOUSE NM_029010 Q8CDK6 Q8VC60 Q9D631 uc011wnk.1 uc011wnk.2 uc011wnk.3 Probable glycosyl hydrolase. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VC60-1; Sequence=Displayed; Name=2; IsoId=Q8VC60-2; Sequence=VSP_030060, VSP_030061, VSP_030062; Belongs to the glycosyl hydrolase 35 family. hydrolase activity, hydrolyzing O-glycosyl compounds beta-galactosidase activity extracellular region extracellular space vacuole carbohydrate metabolic process metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds uc011wnk.1 uc011wnk.2 uc011wnk.3 
ENSMUST00000113624.3 Rora ENSMUST00000113624.3 RAR-related orphan receptor alpha, transcript variant 2 (from RefSeq NM_001289916.2) ENSMUST00000113624.1 ENSMUST00000113624.2 NM_001289916 Q3U1P4 Q3U1P4_MOUSE Rora uc009qna.1 uc009qna.2 uc009qna.3 uc009qna.4 The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. Nucleus Belongs to the nuclear hormone receptor family. NR1 subfamily. DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding nucleus regulation of transcription, DNA-templated zinc ion binding intracellular receptor signaling pathway steroid hormone mediated signaling pathway sequence-specific DNA binding metal ion binding uc009qna.1 uc009qna.2 uc009qna.3 uc009qna.4 
ENSMUST00000113627.4 Pin4 ENSMUST00000113627.4 peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin), transcript variant 1 (from RefSeq NM_027181.3) ENSMUST00000113627.1 ENSMUST00000113627.2 ENSMUST00000113627.3 NM_027181 PIN4_MOUSE Q0VE57 Q9CWW6 uc009tyj.1 uc009tyj.2 uc009tyj.3 Involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA (By similarity). Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Found in pre-ribosomal ribonucleoprotein (pre-rRNP) complexes. Nucleus, nucleolus Cytoplasm, cytoskeleton, spindle Cytoplasm Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1. Phosphorylated. Phosphorylation occurs both in the nucleus and the cytoplasm. Phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated form associates with the pre-rRNP complexes in the nucleus (By similarity). Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily. protein peptidyl-prolyl isomerization DNA binding bent DNA binding double-stranded DNA binding peptidyl-prolyl cis-trans isomerase activity nucleus nucleolus cytoplasm mitochondrial matrix spindle cytoskeleton rRNA processing isomerase activity preribosome uc009tyj.1 uc009tyj.2 uc009tyj.3 
ENSMUST00000113637.9 Arhgap25 ENSMUST00000113637.9 Rho GTPase activating protein 25, transcript variant 1 (from RefSeq NM_001037727.2) B2RS69 ENSMUST00000113637.1 ENSMUST00000113637.2 ENSMUST00000113637.3 ENSMUST00000113637.4 ENSMUST00000113637.5 ENSMUST00000113637.6 ENSMUST00000113637.7 ENSMUST00000113637.8 Kiaa0053 NM_001037727 Q2VPR2 Q3TE04 Q3TVX0 Q3UVB7 Q6A0E0 Q8BX98 Q8BYW1 RHG25_MOUSE uc009ctm.1 uc009ctm.2 uc009ctm.3 uc009ctm.4 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BYW1-1; Sequence=Displayed; Name=2; IsoId=Q8BYW1-2; Sequence=VSP_019233; Name=3; IsoId=Q8BYW1-3; Sequence=VSP_019234; Sequence=BAC29857.1; Type=Erroneous initiation; Evidence=; phagocytic cup molecular_function GTPase activator activity phagocytosis, engulfment actin filament organization signal transduction positive regulation of GTPase activity negative regulation of small GTPase mediated signal transduction uc009ctm.1 uc009ctm.2 uc009ctm.3 uc009ctm.4 
ENSMUST00000113641.4 Kat5 ENSMUST00000113641.4 K(lysine) acetyltransferase 5, transcript variant 1 (from RefSeq NM_178637.2) A0A494B9U8 A1L394 ENSMUST00000113641.1 ENSMUST00000113641.2 ENSMUST00000113641.3 Htatip KAT5_MOUSE Kat5 NM_178637 Q3YFI9 Q8CGZ3 Q8CGZ4 Q8CHK4 Q8VIH0 Tip60 uc008gdz.1 uc008gdz.2 uc008gdz.3 uc008gdz.4 uc008gdz.5 Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:28694333, PubMed:30297459, PubMed:32542325). Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (By similarity). The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17728759). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:30297459). Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (By similarity). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (PubMed:32542325). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (PubMed:28694333). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, ULK1 and RUBCNL/Pacer (PubMed:22539723, PubMed:24835996, PubMed:31294688). Directly acetylates and activates ATM (By similarity). Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (By similarity). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (By similarity). Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:24835996). Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311). Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (By similarity). Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (PubMed:31294688). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:22539723). Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (By similarity). Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:29765047). Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (By similarity). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and 2- hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation and 2-hydroxyisobutyrylation, respectively (By similarity). Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (By similarity). Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (By similarity). Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (By similarity). Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (By similarity). Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (By similarity). Reaction=acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L- lysyl-[histone]; Xref=Rhea:RHEA:21992, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:11338, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21993; Evidence=; Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45949; Evidence= Reaction=(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)- (2E)-butenoyl-L-lysyl-[protein]; Xref=Rhea:RHEA:53908, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:13707, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57332, ChEBI:CHEBI:137954; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53909; Evidence=; Reaction=2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]; Xref=Rhea:RHEA:24180, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:15921, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:131780, ChEBI:CHEBI:144968; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24181; Evidence=; Acyltransferase and acetyltransferase activities are activated by phosphorylation and autoacetylation (PubMed:22539723). Autoacetylation activates the histone acetyltransferase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 (PubMed:32542325). KAT5/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4 (By similarity). The NuA4 complex interacts with MYC (By similarity). Interacts with ATM (By similarity). Interacts with JADE1 (By similarity). Interacts with PLA2G4A/CPLA2, EDNRA and HDAC7 (By similarity). Interacts with the cytoplasmic tail of APP and APBB1/FE65 (By similarity). Interacts with TRIM24 and TRIM68 (By similarity). Forms a complex with SENP6 and UBE2I in response to UV irradiation (By similarity). Identified in a complex with HINT1 (By similarity). Interacts with ATF2 and CUL3 (By similarity). Interacts with NR1D2 (via N-terminus) (By similarity). Component of a SWR1-like complex (By similarity). Interacts with FOXP3 (PubMed:19696312). Interacts with ZBTB49 (By similarity). Interacts with SRF (PubMed:16597624). Interacts with ATF3; promoting autoacetylation and deubiquitination by USP7 (By similarity). Interacts with EP300/p300; interaction promotes KAT5 autoacetylation (By similarity). Interacts with PRKDC; interaction is impaired following KAT5 sumoylation (By similarity). Interacts with GPR50 (By similarity). Q8CHK4; P54254: Atxn1; NbExp=2; IntAct=EBI-1169948, EBI-1169713; Q8CHK4; O88495: Gpr50; NbExp=3; IntAct=EBI-1169948, EBI-21227860; Nucleus Chromosome Cytoplasm Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle pole Nucleus, nucleolus Cytoplasm, perinuclear region Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies (By similarity). Transiently localizes to kinetochores in early mitosis (By similarity). Localizes to spindle poles when chromosomes align during metaphase (By similarity). Localizes in the cytoplasm and nucleus of round spermatids (PubMed:28694333). Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Tip60alpha ; IsoId=Q8CHK4-1; Sequence=Displayed; Name=2; Synonyms=Tip60beta ; IsoId=Q8CHK4-2; Sequence=VSP_009107; Name=3; Synonyms=Ltip60 ; IsoId=Q8CHK4-3; Sequence=VSP_009106; Name=4; IsoId=Q8CHK4-4; Sequence=VSP_009105; Name=5; Synonyms=Tip55 ; IsoId=Q8CHK4-5; Sequence=VSP_061400, VSP_061401; Expressed in testis, heart, brain, kidney and liver. Weakly expressed in lung. Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase (PubMed:22539723, PubMed:30297459, PubMed:34608293). The phosphorylated form has a higher activity (PubMed:30297459, PubMed:34608293). Phosphorylation at Ser-90 by CDK1 or CDK9 is a prerequisite for phosphorylation at Ser-86 by GSK3 (PubMed:34608293). Phosphorylation at Ser-86 by GSK3 (GSK3A or GSK3B) activates acetyltransferase and acyltransferase activity (PubMed:22539723, PubMed:30297459). Phosphorylation at Ser-90 by CDK9 promotes KAT5 recruitment to chromatin (By similarity). Phosphorylation by VRK1 following DNA damage promotes KAT5 association with chromatin and histone acetyltransferase activity (PubMed:33076429). Autoacetylated (By similarity). Autoacetylation is required for histone acetyltransferase activity (By similarity). Autoacetylation at Lys-327 is facilitated by interaction with EP300/p300: it prevents ubiquitination and subsequent degradation by the proteasome and promotes acetylation of target proteins (By similarity). Deacetylated by HDAC3 and SIRT1 (By similarity). Deacetylation by HDAC3 promotes its ubiquitination and cytoplasmic localization (By similarity). Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies (By similarity). Sumoylation with SUMO2 by PIAS4 at Lys-430 promotes repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity). Sumoylation by PIAS4 impairs interaction with PRKDC, inhibiting non-homologous end joining (NHEJ)-mediated repair of DSBs, thereby facilitating HR (By similarity). Desumoylated by SENP3 (By similarity). Ubiquitinated by MDM2, leading to its proteasome-dependent degradation (By similarity). Ubiquitination is prevented by autoacetylation at Lys-327 (By similarity). Ubiquitinated following deacetylation by HDAC3, leading to cytoplasmic localization (By similarity). Deubiquitinated by USP7 following interaction with ATF3, promoting its stabilization (By similarity). Embryonic lethality before implantation (PubMed:17728759). Conditional deletion leads to rapid hematopoietic stem cell loss in both fetal and adult stages (PubMed:32542325). Conditional deletion at postnatal day 15 leads to impaired spermatid development: testes are smaller and show defects in the transition from the transition from round to elongating spermatids (PubMed:28694333). Defects in spermatid development is probably caused by impaired acetylation of histones that affects histone replacement (PubMed:28694333). Conditional deletion in response to DNA damage leads to impaired homologous recombination (HR)repair in response to DNA double-strand breaks (DSBs), associated with increased non-homologous end joining (NHEJ)-mediated repair mediated by TP53BP1 (PubMed:30297459). [Isoform 5]: Mice lacking isoform 5 die during mid-gestation (around embryonic day 11.5) (PubMed:30297694). Prior to developmental arrest, embryos display defects in heart and neural tube (PubMed:30297694). Specification of cardiac and neural cell fates is first normal; however, cell division and survival are impaired in heart and neural tube, respectively (PubMed:30297694). Belongs to the MYST (SAS/MOZ) family. negative regulation of transcription from RNA polymerase II promoter histone acetyltransferase complex nuclear chromatin Swr1 complex chromatin binding transcription coactivator activity histone acetyltransferase activity protein binding nucleus nucleoplasm transcription factor complex nucleolus cytoplasm cytosol double-strand break repair chromatin organization regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator transcription factor binding response to ionizing radiation H4 histone acetyltransferase activity positive regulation of autophagy histone acetylation transferase activity transferase activity, transferring acyl groups peptidyl-lysine acetylation negative regulation of interleukin-2 production Piccolo NuA4 histone acetyltransferase complex macromolecular complex NuA4 histone acetyltransferase complex regulation of growth histone binding proteasome-mediated ubiquitin-dependent protein catabolic process phospholipase binding histone H4 acetylation macromolecular complex binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding perinuclear region of cytoplasm peptide-lysine-N-acetyltransferase activity repressing transcription factor binding cellular response to estradiol stimulus positive regulation of protein acetylation uc008gdz.1 uc008gdz.2 uc008gdz.3 uc008gdz.4 uc008gdz.5 
ENSMUST00000113654.8 Lrrc8a ENSMUST00000113654.8 Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:30135305, PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2'-3'-cGAMP, thereby promoting transfer of 2'-3'-cGAMP to bystander cells (PubMed:32277911). In contrast, complexes containing LRRC8D inhibit transport of 2'-3'-cGAMP (By similarity). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297). Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (PubMed:31387946, PubMed:32930093). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29371604, PubMed:29773801). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (By similarity). (from UniProt Q80WG5) A2AQZ0 BC048152 ENSMUST00000113654.1 ENSMUST00000113654.2 ENSMUST00000113654.3 ENSMUST00000113654.4 ENSMUST00000113654.5 ENSMUST00000113654.6 ENSMUST00000113654.7 LRC8A_MOUSE Lrrc8 Lrrc8a Q80WG5 uc289urh.1 uc289urh.2 Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:30135305, PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2'-3'-cGAMP, thereby promoting transfer of 2'-3'-cGAMP to bystander cells (PubMed:32277911). In contrast, complexes containing LRRC8D inhibit transport of 2'-3'-cGAMP (By similarity). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297). Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (PubMed:31387946, PubMed:32930093). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29371604, PubMed:29773801). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (By similarity). Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324, ChEBI:CHEBI:16382; Evidence=; Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328, ChEBI:CHEBI:507393; Evidence=; Reaction=L-aspartate(out) = L-aspartate(in); Xref=Rhea:RHEA:66332, ChEBI:CHEBI:29991; Evidence=; Reaction=L-glutamate(out) = L-glutamate(in); Xref=Rhea:RHEA:66336, ChEBI:CHEBI:29985; Evidence=; Reaction=myo-inositol(out) = myo-inositol(in); Xref=Rhea:RHEA:32867, ChEBI:CHEBI:17268; Evidence=; Reaction=2',3'-cGAMP(out) = 2',3'-cGAMP(in); Xref=Rhea:RHEA:66320, ChEBI:CHEBI:143093; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66321; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:66322; Evidence=; Inhibited by (4-[(2-butyl-6,7-dichloro-2- cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid), which plugs the channel like a cork in a bottle by binding in the extracellular selectivity filter and sterically occluding ion conduction. Hexamer; forms a trimer of dimers (PubMed:29769723, PubMed:30775971). Heterohexamer; oligomerizes with other LRRC8 proteins (LRRC8B, LRRC8C, LRRC8D and/or LRRC8E) to form a heterohexamer (PubMed:24782309, PubMed:29769723). Can form homohexamers in vitro, but these have lower conductance than heterohexamers (PubMed:29769723). Detected in a channel complex that contains LRRC8A, LRRC8C and LRRC8E (By similarity). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable). Interact with GRB2 (PubMed:32930093). Q80WG5; Q80WG5: Lrrc8a; NbExp=4; IntAct=EBI-20718010, EBI-20718010; Cell membrane ulti-pass membrane protein sosome membrane ; Multi-pass membrane protein Note=Mainly localizes to the cell membrane, with some intracellular localization to lysosomes. Ubiquitously expressed (PubMed:24725410, PubMed:30135305). High levels detected in the bone marrow; lower levels found in peripheral blood cells (PubMed:14660746, PubMed:15094057, PubMed:24752297). Highly expressed in pancreatic beta cells (PubMed:29773801). The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins. The di-leucine motif is required for lysosomal localization. The cytoplasmic N-terminus preceding the first transmembrane (residues 1-22) regulates volume-regulated anion channel (VRAC) conductance, ion permeability and inactivation gating. N-glycosylated. Note=Defects in Lrrc8a are the cause of ebouriffe (ebo), a spontaneous mutation that causes male sterility (PubMed:8828840, PubMed:28192143, PubMed:30135305). Spermatozoa present in the epididymis display severe malformations, mostly of the tail (PubMed:8828840, PubMed:28192143). A drastic decrease of the spermatid population is observed, whereas spermatogonia and spermatocytes seem moderately affected (PubMed:8828840, PubMed:28192143). Defects are caused by decreased volume-regulated anion channel (VRAC) activity in germ cells (PubMed:30135305). Oogenesis is not affected but embryos derived from ebo/ebo females show early developmental failure (PubMed:30135305). Increased prenatal and postnatal mortality, growth retardation, and multiple tissue abnormalities (PubMed:24752297). B-cell development is slightly impaired, without affecting B-cell function (PubMed:24752297). Mice however show a cell- autonomous early block in thymocyte development and impairs peripheral T-cell expansion and function (PubMed:24752297). Conditional deletion in germ cells leads to abnormal sperm and male infertility: the cytoplasm of late spermatids appears swollen, preventing reduction of the cytoplasm during further development into spermatozoa (PubMed:29880644, PubMed:30135305). Spermatozoa display severely disorganized mitochondrial sheaths in the midpiece region, as well as angulated or coiled flagella, resulting in dramatically reduced sperm motility (PubMed:29880644). Conditional deletion in Sertoli cells does not affect male fertility (PubMed:29880644). Conditional deletion in pancreatic beta cells have normal resting serum glucose levels but impaired glucose tolerance (PubMed:29371604, PubMed:29773801). Conditional deletion in myotubes leads to impaired myoblast differentiation: mice have smaller myofibers, generate less force ex vivo, and display reduced exercise endurance, associated with increased adiposity under basal conditions, and glucose intolerance and insulin resistance when raised on a high-fat diet (PubMed:32930093). Belongs to the LRRC8 family. pre-B cell differentiation volume-sensitive anion channel activity plasma membrane integral component of plasma membrane ion transport anion transport cell volume homeostasis response to osmotic stress cell surface inorganic anion transport taurine transport aspartate transport membrane integral component of membrane cell differentiation protein hexamerization ion channel complex identical protein binding anion transmembrane transport anion channel activity uc289urh.1 uc289urh.2 
ENSMUST00000113658.8 Gfpt1 ENSMUST00000113658.8 glutamine fructose-6-phosphate transaminase 1 (from RefSeq NM_013528.3) ENSMUST00000113658.1 ENSMUST00000113658.2 ENSMUST00000113658.3 ENSMUST00000113658.4 ENSMUST00000113658.5 ENSMUST00000113658.6 ENSMUST00000113658.7 GFPT1_MOUSE Gfpt NM_013528 P47856 Q91XG9 Q99LP7 Q99MJ4 uc009csz.1 uc009csz.2 uc009csz.3 uc009csz.4 Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1 (PubMed:23395176). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling (By similarity). Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6- phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985, ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=2.6.1.16; Evidence=; Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D- fructose 6-phosphate: step 1/1. Homotetramer, may also exist as homodimers. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=GFAT1m; IsoId=P47856-1; Sequence=Displayed; Name=2; IsoId=P47856-2; Sequence=VSP_007498; Isoform 1 is predominantly expressed in hindlimb muscle and is also expressed weakly in the heart. Seems to be selectively expressed in striated muscle. Expression in the liver oscillates in an ultradian manner (with a 12 hour period/cycle). glutamine-fructose-6-phosphate transaminase (isomerizing) activity fructose 6-phosphate metabolic process glucosamine biosynthetic process UDP-N-acetylglucosamine metabolic process UDP-N-acetylglucosamine biosynthetic process protein N-linked glycosylation glutamine metabolic process transaminase activity amino acid binding transferase activity carbohydrate binding circadian regulation of gene expression negative regulation of glycogen biosynthetic process rhythmic process protein homotetramerization carbohydrate derivative binding carbohydrate derivative metabolic process carbohydrate derivative biosynthetic process uc009csz.1 uc009csz.2 uc009csz.3 uc009csz.4 
ENSMUST00000113671.3 Gm21986 ENSMUST00000113671.3 Gm21986 (from geneSymbol) AK173182 ENSMUST00000113671.1 ENSMUST00000113671.2 uc292prt.1 uc292prt.2 uc292prt.1 uc292prt.2 
ENSMUST00000113677.3 Zer1 ENSMUST00000113677.3 zyg-11 related, cell cycle regulator, transcript variant 2 (from RefSeq NM_001290503.1) A2BEA2 ENSMUST00000113677.1 ENSMUST00000113677.2 NM_001290503 Q6PGH5 Q80ZJ6 Q8BG38 ZER1_MOUSE Zer1 Zyg Zyg11bl uc008jbg.1 uc008jbg.2 uc008jbg.3 uc008jbg.4 Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation. Interacts with the ELOC-ELOB/Elongin BC complex. Part of an E3 ubiquitin ligase complex including ZER1, CUL2 and Elongin BC. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80ZJ6-1; Sequence=Displayed; Name=2; IsoId=Q80ZJ6-2; Sequence=VSP_014425; Name=3; IsoId=Q80ZJ6-3; Sequence=VSP_014425, VSP_014426, VSP_014427; Belongs to the zyg-11 family. Cul2-RING ubiquitin ligase complex uc008jbg.1 uc008jbg.2 uc008jbg.3 uc008jbg.4 
ENSMUST00000113682.9 Myg1 ENSMUST00000113682.9 melanocyte proliferating gene 1 (from RefSeq NM_021713.2) ENSMUST00000113682.1 ENSMUST00000113682.2 ENSMUST00000113682.3 ENSMUST00000113682.4 ENSMUST00000113682.5 ENSMUST00000113682.6 ENSMUST00000113682.7 ENSMUST00000113682.8 MYG1_MOUSE Myg1 NM_021713 Q9CYX0 Q9JK81 uc007xvi.1 uc007xvi.2 uc007xvi.3 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (PubMed:31081026). Nucleus, nucleoplasm Mitochondrion matrix cleus, nucleolus Ubiquitously expressed, with highest levels in testis. Strongly up-regulated from 7 dpc to 11 dpc. Widely expressed at 8.5 dpc. At 11.75 dpc, expression is strongest in developing neuroepithelium and eye. Mutants are vital, fertile and display no gross abnormalities. They show an inconsistent pattern of altered anxiety- like behavior. Mutant males are significantly less anxious than their wild-type littermates, females show increased anxiety in the locomotor activity arena. Belongs to the MYG1 family. molecular_function nucleus nucleoplasm mitochondrion locomotory exploration behavior uc007xvi.1 uc007xvi.2 uc007xvi.3 
ENSMUST00000113707.9 Tpm1 ENSMUST00000113707.9 tropomyosin 1, alpha, transcript variant Tpm1.6 (from RefSeq NM_024427.4) ENSMUST00000113707.1 ENSMUST00000113707.2 ENSMUST00000113707.3 ENSMUST00000113707.4 ENSMUST00000113707.5 ENSMUST00000113707.6 ENSMUST00000113707.7 ENSMUST00000113707.8 NM_024427 Q564G1 Q564G1_MOUSE Tpm1 uc009qfp.1 uc009qfp.2 uc009qfp.3 Cytoplasm, cytoskeleton Belongs to the tropomyosin family. stress fiber cytosol cytoskeletal protein binding regulation of cell shape actin cytoskeleton bleb ruffle membrane cellular response to reactive oxygen species sarcomere organization ventricular cardiac muscle tissue morphogenesis cardiac muscle contraction negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration uc009qfp.1 uc009qfp.2 uc009qfp.3 
ENSMUST00000113710.8 Slc7a3 ENSMUST00000113710.8 Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:9334265). The transport is sodium ions- and pH-independent, moderately trans- stimulated and is mediated by passive diffusion (PubMed:9334265). (from UniProt P70423) AK141558 Atrc3 B1AVE2 CTR3_MOUSE Cat3 ENSMUST00000113710.1 ENSMUST00000113710.2 ENSMUST00000113710.3 ENSMUST00000113710.4 ENSMUST00000113710.5 ENSMUST00000113710.6 ENSMUST00000113710.7 P70423 Slc7a3 uc292pqx.1 uc292pqx.2 Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:9334265). The transport is sodium ions- and pH-independent, moderately trans- stimulated and is mediated by passive diffusion (PubMed:9334265). Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143, ChEBI:CHEBI:32682; Evidence=; Reaction=L-lysine(in) = L-lysine(out); Xref=Rhea:RHEA:70935, ChEBI:CHEBI:32551; Evidence=; Reaction=L-ornithine(in) = L-ornithine(out); Xref=Rhea:RHEA:71199, ChEBI:CHEBI:46911; Evidence=; Kinetic parameters: KM=110 uM for L-lysine ; KM=100 uM for L-arginine ; Cell membrane; Multi-pass membrane protein. Expressed in adult brain and in a wide variety of embryonic tissues. N-glycosylated. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. L-ornithine transmembrane transporter activity plasma membrane amino acid transport basic amino acid transmembrane transporter activity arginine transmembrane transporter activity L-lysine transmembrane transporter activity arginine transport lysine transport ornithine transport membrane integral component of membrane transmembrane transporter activity regulation of TOR signaling transmembrane transport L-arginine import across plasma membrane L-alpha-amino acid transmembrane transport L-ornithine transmembrane transport L-lysine transmembrane transport uc292pqx.1 uc292pqx.2 
ENSMUST00000113711.3 Dync2i2 ENSMUST00000113711.3 dynein 2 intermediate chain 2 (from RefSeq NM_001008498.2) A2BE91 DC2I2_MOUSE ENSMUST00000113711.1 ENSMUST00000113711.2 NM_001008498 Q5U4F6 Wdr34 uc008jau.1 uc008jau.2 uc008jau.3 uc008jau.4 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis (PubMed:28379358). Required also to maintain a functional transition zone (By similarity). Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation. The cytoplasmic dynein 2 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs). Among them, a heavy chain (DYNC2H1), two intermediate chains (DYNC2I2 and DYNC2I1), a light intermediate chain (DYNC2LI1), and a light chain (DYNLT2B) are unique to the cytoplasmic dynein complex 2, but a subset of the light chains are also shared by dynein-1 and dynein-2 complexes. Interacts with DYNC2I1; their C-terminal domains each bind a copy of the heavy chain, and their extended N- terminal regions are held together by an array of light chain dimers. Interacts with DYNLL2; this interaction is essential for dynein-2- mediated retrograde trafficking of ciliary proteins. Interacts with DYNLRB1; this interaction is essential for dynein-2-mediated retrograde trafficking of ciliary proteins. Interacts (via the WD domains) with MAP3K7 and TAB3. Interacts (via WD domains) with TAB2 (via C-terminus). Interacts (via WD domains) with TRAF6 (via TRAF-type domains). Cytoplasm Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, cilium axoneme Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cell projection, filopodium Note=Concentrates around the centrioles and basal bodies also showing axonemal staining. Expressed in brain, thymus, heart, lung, liver, spleen, kidney, testis and intestine. The majority of deficient mice die in midgestation from 10.5 dpc to 12.5 dpc. The mutant embryos exhibit open brain, spinal bifida, microphthalmia, and polydactyly. Inactivation of the protein results also in short and stumpy cilia with an abnormal accumulation of ciliary proteins and defects in Sonic hedgehog signaling. Belongs to the dynein light intermediate chain family. Sequence=AAH85113.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding cytoplasm centriole cytosol cytoskeleton cytoplasmic dynein complex axoneme microtubule-based movement ciliary basal body intraciliary transport cell projection dynein light chain binding dynein heavy chain binding cilium assembly ATP-dependent microtubule motor activity, plus-end-directed uc008jau.1 uc008jau.2 uc008jau.3 uc008jau.4 
ENSMUST00000113718.8 Tex11 ENSMUST00000113718.8 Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. (from UniProt Q14AT2) AK029799 ENSMUST00000113718.1 ENSMUST00000113718.2 ENSMUST00000113718.3 ENSMUST00000113718.4 ENSMUST00000113718.5 ENSMUST00000113718.6 ENSMUST00000113718.7 Q14AT2 Q8BUS0 Q99MW9 TEX11_MOUSE Zip4 uc292pqr.1 uc292pqr.2 Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. Interacts with SYCP2 (PubMed:18316482). Interacts with PBXIP1; may prevent interaction between PBXIP1 and ESR2 (PubMed:22383461). Interacts with SHOC1 (By similarity). Interacts with REDIC1. Chromosome te=Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14AT2-1; Sequence=Displayed; Name=2; IsoId=Q14AT2-2; Sequence=VSP_027262, VSP_027263; Testis-specific. In spermatocytes, not observed on asynapsed chromosomes in leptotene and appears on synapsed regions in zygotene and on the fully synapsed chromosomes in early pachytene. Disappears in late pachytene and is not observed in diplotene spermatocytes. A similar localization is detected on female meiotic chromosomes (at protein level). Defects in meiotic double-strand breaks (DSBs) repair and reduced crossover formation. However, discrepancies exist between the different reports. According to a report, deletion induces male sterility (PubMed:18316482). Females are fertile with reduced litter. Adult mice show an arrest in male meiosis and aberrant chromosome segregation in anaphase spermatocytes. Chromosomal asynapsis and reduced crossover formation are observed, leading to elimination of spermatocytes at the pachytene and anaphase I stages (PubMed:18316482). According to another report, both male and female mice are fertile and produce normal-sized litters with normal Mendelian ratios (PubMed:18369460). Represent the only meiosis-specific factor encoded by the chromosome X in mouse. Belongs to the SPO22 family. resolution of meiotic recombination intermediates condensed nuclear chromosome central element protein binding chromosome meiotic gene conversion male meiosis chromosome segregation synaptonemal complex assembly reciprocal meiotic recombination male meiosis male gonad development fertilization negative regulation of apoptotic process chiasma assembly meiotic cell cycle synaptonemal complex uc292pqr.1 uc292pqr.2 
ENSMUST00000113721.8 Rnf25 ENSMUST00000113721.8 ring finger protein 25, transcript variant 2 (from RefSeq NM_001305230.1) E9Q446 E9Q446_MOUSE ENSMUST00000113721.1 ENSMUST00000113721.2 ENSMUST00000113721.3 ENSMUST00000113721.4 ENSMUST00000113721.5 ENSMUST00000113721.6 ENSMUST00000113721.7 NM_001305230 Rnf25 uc007bmt.1 uc007bmt.2 uc007bmt.3 uc007bmt.4 uc007bmt.5 protein ubiquitination ubiquitin protein ligase activity uc007bmt.1 uc007bmt.2 uc007bmt.3 uc007bmt.4 uc007bmt.5 
ENSMUST00000113742.3 H2-T15 ENSMUST00000113742.3 histocompatibility 2, T region locus 27 (from RefSeq NM_001199967.2) A7VMS2 A7VMS2_MOUSE ENSMUST00000113742.1 ENSMUST00000113742.2 Gm11127 H2-T15 H2-T27 NM_001199967 uc008cjz.1 uc008cjz.2 uc008cjz.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc008cjz.1 uc008cjz.2 uc008cjz.3 
ENSMUST00000113760.10 H2-T24 ENSMUST00000113760.10 histocompatibility 2, T region locus 24 (from RefSeq NM_008207.3) ENSMUST00000113760.1 ENSMUST00000113760.2 ENSMUST00000113760.3 ENSMUST00000113760.4 ENSMUST00000113760.5 ENSMUST00000113760.6 ENSMUST00000113760.7 ENSMUST00000113760.8 ENSMUST00000113760.9 F8VQG4 F8VQG4_MOUSE H2-T24 NM_008207 uc008cjq.1 uc008cjq.2 Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc008cjq.1 uc008cjq.2 
ENSMUST00000113765.8 Odf2 ENSMUST00000113765.8 outer dense fiber of sperm tails 2, transcript variant 9 (from RefSeq NM_001369060.2) A3KGV1 A3KGV5 A3KGV6 ENSMUST00000113765.1 ENSMUST00000113765.2 ENSMUST00000113765.3 ENSMUST00000113765.4 ENSMUST00000113765.5 ENSMUST00000113765.6 ENSMUST00000113765.7 NM_001369060 O35135 O35496 ODFP2_MOUSE Odf84 Q3TH68 Q3UP80 Q6PGI6 uc289uos.1 uc289uos.2 Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly (By similarity). Self-associates. Associates with microtubules and forms a fibrillar structure partially linked to the microtubule network. Interacts via its C-terminus with PLK1 (By similarity). Interacts with ODF1 (PubMed:9045620). Interacts with MARK4; the interaction is required for localization of ODF2 to centrioles (By similarity). Interacts with TSSK4 (PubMed:25361759, PubMed:26961893). Interacts with AKNA (PubMed:30787442). Interacts with CFAP58 (PubMed:31904090). Interacts with BBOF1 (PubMed:37198331). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome ll projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle pole Cell projection, cilium, flagellum te=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles. Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=A3KGV1-1; Sequence=Displayed; Name=2; IsoId=A3KGV1-2; Sequence=VSP_027672, VSP_027673; Name=3; IsoId=A3KGV1-3; Sequence=VSP_027672; Name=4; IsoId=A3KGV1-4; Sequence=VSP_027672, VSP_027674; Name=5; IsoId=A3KGV1-5; Sequence=VSP_027672, VSP_027675, VSP_027676; Name=6; Synonyms=ODF2/2; IsoId=A3KGV1-6; Sequence=VSP_027673, VSP_027675, VSP_027676; Name=7; Synonyms=ODF2/1; IsoId=A3KGV1-7; Sequence=VSP_027671, VSP_027675, VSP_027676; Testis-specific (at protein level) (PubMed:9045620, PubMed:27682589, PubMed:31904090). Expressed in spermatids at tubular stage V of the spermatogenic cycle (PubMed:9740324). Highly expressed in the cytoplasm of elongating spermatids (tubular stages X/XI) (PubMed:9740324). In step 14/15 spermatids of tubular stage III/IV low expression detected (PubMed:9740324). No expression detected in other testicular cells as well as the early round of spermatids (PubMed:9740324). Tyrosine phosphorylated (By similarity). Phosphorylated on Ser-95 by TSSK4 (PubMed:26961893). Null mutations in F9 embryonic carcinoma cells eliminated distal/subdistal appendages and prevented primary cilium formation. Loss of ODF2 also disrupted two mother centriole-specific NIN dots, while leaving one dot on the proximal end of mother and daughter centrioles. Belongs to the ODF2 family. spindle pole outer dense fiber structural constituent of cytoskeleton protein binding cytoplasm centrosome centriole microtubule organizing center cytoskeleton microtubule cilium multicellular organism development spermatogenesis spermatid development protein localization centriole-centriole cohesion Rab GTPase binding cell differentiation motile cilium ciliary basal body sperm flagellum cell projection cilium organization ciliary transition fiber regulation of cilium assembly uc289uos.1 uc289uos.2 
ENSMUST00000113768.8 Mx1 ENSMUST00000113768.8 MX dynamin-like GTPase 1, transcript variant 2 (from RefSeq NR_003520.1) ENSMUST00000113768.1 ENSMUST00000113768.2 ENSMUST00000113768.3 ENSMUST00000113768.4 ENSMUST00000113768.5 ENSMUST00000113768.6 ENSMUST00000113768.7 MX1_MOUSE Mx NR_003520 Q3UD61 uc008adh.1 uc008adh.2 uc008adh.3 This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to the influenza virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a deletion or a nonsense mutation that results in a non-functional gene product. [provided by RefSeq, Aug 2015]. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Could be the product of a pseudogene. The sequence shown in this entry is that of an non-functional Mx1 gene product, as it is encoded by the C57BL/6J reference genome (PubMed:19468303). The expression of this gene, if it occurs, would result in a non-functional gene product. Mx1 gene corruption, by a deletion or a nonsense mutation, is also observed in other inbred strains. The functional Mx1 gene is found in some feral mouse strains. Its product is involved in the innate immunity system (PubMed:2903437). nucleotide binding GTPase activity GTP binding uc008adh.1 uc008adh.2 uc008adh.3 
ENSMUST00000113769.8 Arr3 ENSMUST00000113769.8 arrestin 3, retinal (from RefSeq NM_133205.3) ARRC_MOUSE ENSMUST00000113769.1 ENSMUST00000113769.2 ENSMUST00000113769.3 ENSMUST00000113769.4 ENSMUST00000113769.5 ENSMUST00000113769.6 ENSMUST00000113769.7 NM_133205 Q9EQP6 uc009twd.1 uc009twd.2 uc009twd.3 May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins. Homodimer; disulfide-linked in response to retinal illumination (By similarity). Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4 (By similarity). Interacts with GPR84 (By similarity). Photoreceptor inner segment Cell projection, cilium, photoreceptor outer segment Inner and outer segments, and the inner plexiform regions of the retina. At postnatal day 11 (P11) expressed in the soma and photoreceptor processes of the retinal inner segment, outer segment, outer plexiform layer, and inner plexiform layer. Expression in the inner plexiform layer is lost at P22. Belongs to the arrestin family. G-protein coupled receptor binding photoreceptor outer segment photoreceptor inner segment regulation of protein phosphorylation G-protein coupled receptor internalization opsin binding endocytosis signal transduction visual perception protein domain specific binding synapse response to stimulus phosphoprotein binding uc009twd.1 uc009twd.2 uc009twd.3 
ENSMUST00000113773.2 Itgb2l ENSMUST00000113773.2 Cell membrane ingle-pass type I membrane protein Membrane ; Single-pass type I membrane protein (from UniProt D3YXH8) AK036640 D3YXH8 D3YXH8_MOUSE ENSMUST00000113773.1 Itgb2l uc289gnb.1 uc289gnb.2 Cell membrane ingle-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the integrin beta chain family. cell adhesion cell-matrix adhesion integrin-mediated signaling pathway integrin complex membrane integral component of membrane signaling receptor activity uc289gnb.1 uc289gnb.2 
ENSMUST00000113779.8 Eda ENSMUST00000113779.8 ectodysplasin-A, transcript variant 1 (from RefSeq NM_010099.2) ENSMUST00000113779.1 ENSMUST00000113779.2 ENSMUST00000113779.3 ENSMUST00000113779.4 ENSMUST00000113779.5 ENSMUST00000113779.6 ENSMUST00000113779.7 Eda NM_010099 Q3UV69 Q3UV69_MOUSE uc009tvq.1 uc009tvq.2 Secreted Belongs to the tumor necrosis factor family. receptor binding tumor necrosis factor receptor binding lipid particle immune response membrane integral component of membrane odontogenesis of dentin-containing tooth intracellular membrane-bounded organelle positive regulation of NF-kappaB transcription factor activity uc009tvq.1 uc009tvq.2 
ENSMUST00000113792.2 Pja1 ENSMUST00000113792.2 Pja1 (from geneSymbol) BC025975 ENSMUST00000113792.1 Pja1 Q05CG5 Q05CG5_MOUSE uc009tvl.1 uc009tvl.2 uc009tvl.3 protein ubiquitination ubiquitin protein ligase activity uc009tvl.1 uc009tvl.2 uc009tvl.3 
ENSMUST00000113795.8 Gm49948 ENSMUST00000113795.8 Gm49948 (from geneSymbol) AK164699 D3YXH0 D3YXH0_MOUSE ENSMUST00000113795.1 ENSMUST00000113795.2 ENSMUST00000113795.3 ENSMUST00000113795.4 ENSMUST00000113795.5 ENSMUST00000113795.6 ENSMUST00000113795.7 Gm49948 uc008ada.1 uc008ada.2 uc008ada.3 uc008ada.4 uc008ada.5 membrane integral component of membrane uc008ada.1 uc008ada.2 uc008ada.3 uc008ada.4 uc008ada.5 
ENSMUST00000113800.9 B3galt5 ENSMUST00000113800.9 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5, transcript variant 2 (from RefSeq NM_001122993.1) B3GT5_MOUSE B3galt5 B3gt5 ENSMUST00000113800.1 ENSMUST00000113800.2 ENSMUST00000113800.3 ENSMUST00000113800.4 ENSMUST00000113800.5 ENSMUST00000113800.6 ENSMUST00000113800.7 ENSMUST00000113800.8 NM_001122993 Q9JI67 uc008acv.1 uc008acv.2 uc008acv.3 uc008acv.4 Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor. Also catalyzes the transfer of Gal to the terminal GalNAc unit of the globoside GB4, thereby synthesizing the glycolipid GB5, also known as the stage-specific embryonic antigen-3 (SSEA-3). Reaction=a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = a globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:41996, ChEBI:CHEBI:15378, ChEBI:CHEBI:18259, ChEBI:CHEBI:58223, ChEBI:CHEBI:62571, ChEBI:CHEBI:66914; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41997; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Expressed in brain and kidney. Belongs to the glycosyltransferase 31 family. Name=Functional Glycomics Gateway - GTase; Note=b3GalT5; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_458"; Golgi membrane endoplasmic reticulum Golgi apparatus protein glycosylation protein N-linked glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity oligosaccharide biosynthetic process response to bacterium membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups uc008acv.1 uc008acv.2 uc008acv.3 uc008acv.4 
ENSMUST00000113804.8 Lca5l ENSMUST00000113804.8 Belongs to the LCA5 family. (from UniProt A0A5H1ZRL0) A0A5H1ZRL0 A0A5H1ZRL0_MOUSE AK029554 ENSMUST00000113804.1 ENSMUST00000113804.2 ENSMUST00000113804.3 ENSMUST00000113804.4 ENSMUST00000113804.5 ENSMUST00000113804.6 ENSMUST00000113804.7 Lca5l uc289gmk.1 uc289gmk.2 Belongs to the LCA5 family. uc289gmk.1 uc289gmk.2 
ENSMUST00000113810.10 Gm13547 ENSMUST00000113810.10 predicted gene 13547 (from RefSeq NR_178077.1) ENSMUST00000113810.1 ENSMUST00000113810.2 ENSMUST00000113810.3 ENSMUST00000113810.4 ENSMUST00000113810.5 ENSMUST00000113810.6 ENSMUST00000113810.7 ENSMUST00000113810.8 ENSMUST00000113810.9 NR_178077 uc012btg.1 uc012btg.2 uc012btg.3 uc012btg.1 uc012btg.2 uc012btg.3 
ENSMUST00000113820.9 Arpc2 ENSMUST00000113820.9 actin related protein 2/3 complex, subunit 2, transcript variant 2 (from RefSeq NM_001357387.1) ARPC2_MOUSE ENSMUST00000113820.1 ENSMUST00000113820.2 ENSMUST00000113820.3 ENSMUST00000113820.4 ENSMUST00000113820.5 ENSMUST00000113820.6 ENSMUST00000113820.7 ENSMUST00000113820.8 NM_001357387 Q3U870 Q9CVB6 uc007bln.1 uc007bln.2 uc007bln.3 Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC (By similarity). Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex (PubMed:24153177). Interacts with DNAI3; this interaction reduces binding of the Arp2/3 complex to the VCA domain of nucleation promoting factors (By similarity). Cytoplasm, cytoskeleton Cell projection Synapse, synaptosome Nucleus Expressed in hippocampal neurons (at protein level). Belongs to the ARPC2 family. actin binding structural constituent of cytoskeleton protein binding nucleus cytoplasm endosome cytoskeleton Arp2/3 protein complex plasma membrane focal adhesion cell surface positive regulation of lamellipodium assembly positive regulation of smooth muscle cell migration actin cytoskeleton lamellipodium actin filament polymerization cell junction secretory granule growth cone regulation of actin filament polymerization positive regulation of actin filament polymerization cell leading edge filamentous actin ruffle membrane Arp2/3 complex-mediated actin nucleation glutamate receptor binding site of double-strand break cellular response to platelet-derived growth factor stimulus muscle cell projection membrane cell projection neuron projection dendritic spine dendritic shaft perikaryon axon terminus macromolecular complex binding synapse actin filament binding ATPase binding positive regulation of filopodium assembly protein kinase C signaling cellular response to epidermal growth factor stimulus invadopodium positive regulation of podosome assembly cellular response to rapamycin positive regulation of protein targeting to membrane peripheral region of growth cone apical dendrite glutamatergic synapse positive regulation of substrate adhesion-dependent cell spreading positive regulation of actin cytoskeleton reorganization positive regulation of barbed-end actin filament capping uc007bln.1 uc007bln.2 uc007bln.3 
ENSMUST00000113822.3 Lrfn4 ENSMUST00000113822.3 leucine rich repeat and fibronectin type III domain containing 4, transcript variant 2 (from RefSeq NM_153388.5) ENSMUST00000113822.1 ENSMUST00000113822.2 LRFN4_MOUSE NM_153388 Q3TQG8 Q460G5 Q80XU8 Q8K3C4 Salm3 uc008gai.1 uc008gai.2 uc008gai.3 uc008gai.4 Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery. Can form heteromeric complexes with LRFN1, LRFN2, LRFN3 and LRFN5. Unable to form homophilic interactions across cell junctions. Interacts with DLG1, DLG2 and DLG3 (By similarity). Also interacts with DLG4. Membrane ingle-pass type I membrane protein Expressed in brain and testis. In the brain, weak, but broad expression in the cerebral cortex and diencephalic nuclei. Also detected in other parts of the central nervous system, including the olfactory bulb, pons, cerebellum, and medulla oblongata, as well as in the peripheral nervous system, such as the ganglia of cranial nerves and the dorsal root ganglion during gestation. Low expression from 4.5 dpc onwards. Expression increases at 10.5 dpc and decreases after 15.5 dpc. At 11.5 dpc, broadly expressed in the telencephalic and diencephalic vesicles. This pattern of expression continues until 17.5 dpc. The PDZ-binding motif is required for neurite outgrowth promotion. This motif is also involved in DLG1-, DLG3- and DLG4-binding (By similarity). Glycosylated. Belongs to the LRFN family. protein binding cell surface membrane integral component of membrane glutamatergic synapse GABA-ergic synapse integral component of postsynaptic density membrane synaptic membrane adhesion regulation of presynapse assembly uc008gai.1 uc008gai.2 uc008gai.3 uc008gai.4 
ENSMUST00000113824.8 Clpx ENSMUST00000113824.8 caseinolytic mitochondrial matrix peptidase chaperone subunit, transcript variant 2 (from RefSeq NM_001044389.2) Clpx ENSMUST00000113824.1 ENSMUST00000113824.2 ENSMUST00000113824.3 ENSMUST00000113824.4 ENSMUST00000113824.5 ENSMUST00000113824.6 ENSMUST00000113824.7 NM_001044389 Q6P8N8 Q6P8N8_MOUSE uc009qdc.1 uc009qdc.2 uc009qdc.3 uc009qdc.4 Belongs to the ClpX chaperone family. ATP binding protein folding unfolded protein binding uc009qdc.1 uc009qdc.2 uc009qdc.3 uc009qdc.4 
ENSMUST00000113853.3 Ddx31 ENSMUST00000113853.3 DEAD/H box helicase 31, transcript variant 2 (from RefSeq NR_156412.1) A2AIT3 A3KMM3 DDX31_MOUSE ENSMUST00000113853.1 ENSMUST00000113853.2 NR_156412 Q3TLT4 Q6NZQ2 uc008izg.1 uc008izg.2 uc008izg.3 uc008izg.4 Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Interacts with NPM1; the interaction prevents interaction between NPM1 and HDM2. Nucleus, nucleolus Note=Colocalized with NPM1 in the nucleoli. Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily. nucleotide binding nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus nucleolus Golgi apparatus hydrolase activity ribosome biogenesis intracellular membrane-bounded organelle uc008izg.1 uc008izg.2 uc008izg.3 uc008izg.4 
ENSMUST00000113855.8 Kcnj15 ENSMUST00000113855.8 potassium inwardly-rectifying channel, subfamily J, member 15, transcript variant 2 (from RefSeq NM_019664.5) ENSMUST00000113855.1 ENSMUST00000113855.2 ENSMUST00000113855.3 ENSMUST00000113855.4 ENSMUST00000113855.5 ENSMUST00000113855.6 ENSMUST00000113855.7 Kcnj15 Kir4.2 NM_019664 Q53Z04 Q53Z04_MOUSE uc008abw.1 uc008abw.2 uc008abw.3 uc008abw.4 uc008abw.5 Membrane ulti-pass membrane protein Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. inward rectifier potassium channel activity voltage-gated ion channel activity ion transport potassium ion transport membrane integral component of membrane ion transmembrane transport regulation of ion transmembrane transport potassium ion transmembrane transport uc008abw.1 uc008abw.2 uc008abw.3 uc008abw.4 uc008abw.5 
ENSMUST00000113865.5 Rbpj ENSMUST00000113865.5 recombination signal binding protein for immunoglobulin kappa J region, transcript variant 5 (from RefSeq NM_001359152.1) ENSMUST00000113865.1 ENSMUST00000113865.2 ENSMUST00000113865.3 ENSMUST00000113865.4 NM_001359152 Q3UM17 Q3UM17_MOUSE Rbpj Rbpsuh uc008xlj.1 uc008xlj.2 uc008xlj.3 uc008xlj.4 Cytoplasm Nucleus Belongs to the Su(H) family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter uc008xlj.1 uc008xlj.2 uc008xlj.3 uc008xlj.4 
ENSMUST00000113878.8 Arhgef9 ENSMUST00000113878.8 CDC42 guanine nucleotide exchange factor 9, transcript variant 18 (from RefSeq NM_001405915.1) ARHG9_MOUSE B1AXI3 B1AXI5 B9EJ88 ENSMUST00000113878.1 ENSMUST00000113878.2 ENSMUST00000113878.3 ENSMUST00000113878.4 ENSMUST00000113878.5 ENSMUST00000113878.6 ENSMUST00000113878.7 Kiaa0424 NM_001405915 Q3TQ60 Q3UTH8 Q80U06 Q8CAF9 uc009ttu.1 uc009ttu.2 uc009ttu.3 uc009ttu.4 Acts as a guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity). Interacts with GPHN. Cytoplasm Postsynaptic density Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3UTH8-1; Sequence=Displayed; Name=2; IsoId=Q3UTH8-2; Sequence=VSP_021143; Name=3; IsoId=Q3UTH8-3; Sequence=VSP_021144, VSP_021146; Name=4; IsoId=Q3UTH8-4; Sequence=VSP_021145; Detected in embryonic and adult brain. Sequence=BAC65562.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cytoplasm cytosol plasma membrane cell cortex small GTPase mediated signal transduction postsynaptic density membrane cell junction regulation of Rho protein signal transduction receptor clustering synapse postsynaptic membrane GABA-ergic synapse postsynaptic specialization uc009ttu.1 uc009ttu.2 uc009ttu.3 uc009ttu.4 
ENSMUST00000113886.3 Gm11131 ENSMUST00000113886.3 Gm11131 (from geneSymbol) AK158083 ENSMUST00000113886.1 ENSMUST00000113886.2 uc289knf.1 uc289knf.2 uc289knf.1 uc289knf.2 
ENSMUST00000113889.9 Gtf3c5 ENSMUST00000113889.9 general transcription factor IIIC, polypeptide 5, transcript variant 1 (from RefSeq NM_001290484.1) ENSMUST00000113889.1 ENSMUST00000113889.2 ENSMUST00000113889.3 ENSMUST00000113889.4 ENSMUST00000113889.5 ENSMUST00000113889.6 ENSMUST00000113889.7 ENSMUST00000113889.8 NM_001290484 Q8BLE3 Q8R0D0 Q8R2T8 TF3C5_MOUSE uc012bsz.1 uc012bsz.2 uc012bsz.3 uc012bsz.4 Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (By similarity). Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R2T8-1; Sequence=Displayed; Name=2; IsoId=Q8R2T8-2; Sequence=VSP_010356; Belongs to the TFIIIC subunit 5 family. transcription factor TFIIIC complex DNA binding nucleus nucleoplasm transcription initiation from RNA polymerase III promoter skeletal muscle cell differentiation RNA polymerase III transcriptional preinitiation complex assembly transcription factor activity, core RNA polymerase III binding RNA polymerase III type 1 promoter sequence-specific DNA binding RNA polymerase III type 2 promoter sequence-specific DNA binding transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting uc012bsz.1 uc012bsz.2 uc012bsz.3 uc012bsz.4 
ENSMUST00000113893.8 Ralgds ENSMUST00000113893.8 ral guanine nucleotide dissociation stimulator, transcript variant 10 (from RefSeq NR_185206.1) A2AK33 A2AK33_MOUSE ENSMUST00000113893.1 ENSMUST00000113893.2 ENSMUST00000113893.3 ENSMUST00000113893.4 ENSMUST00000113893.5 ENSMUST00000113893.6 ENSMUST00000113893.7 NR_185206 Ralgds uc008iyp.1 uc008iyp.2 uc008iyp.3 uc008iyp.4 guanyl-nucleotide exchange factor activity signal transduction small GTPase mediated signal transduction uc008iyp.1 uc008iyp.2 uc008iyp.3 uc008iyp.4 
ENSMUST00000113898.8 Apoo ENSMUST00000113898.8 apolipoprotein O, transcript variant 1 (from RefSeq NM_026673.4) B1ASQ2 B1ASQ3 ENSMUST00000113898.1 ENSMUST00000113898.2 ENSMUST00000113898.3 ENSMUST00000113898.4 ENSMUST00000113898.5 ENSMUST00000113898.6 ENSMUST00000113898.7 Fam121b MIC26_MOUSE Mic23 Mic26 NM_026673 Q9D186 Q9DCZ4 uc012hmd.1 uc012hmd.2 uc012hmd.3 uc012hmd.4 Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (By similarity). Can induce cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL- associated protein that is subsequently transferred to HDL (By similarity). Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with IMMT/MIC60. Interacts with MICOS10/MIC10 and APOOL/MIC27. Mitochondrion inner membrane ; Single-pass membrane protein Mitochondrion Endoplasmic reticulum membrane Golgi apparatus membrane Note=Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DCZ4-1; Sequence=Displayed; Name=2; IsoId=Q9DCZ4-2; Sequence=VSP_057812; Name=3; IsoId=Q9DCZ4-3; Sequence=VSP_057813; Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family. Golgi membrane extracellular region mitochondrion mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol membrane integral component of membrane integral component of mitochondrial inner membrane cristae formation MICOS complex uc012hmd.1 uc012hmd.2 uc012hmd.3 uc012hmd.4 
ENSMUST00000113900.8 Slc4a5 ENSMUST00000113900.8 Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. (from UniProt E9Q3M5) AK049248 E9Q3M5 ENSMUST00000113900.1 ENSMUST00000113900.2 ENSMUST00000113900.3 ENSMUST00000113900.4 ENSMUST00000113900.5 ENSMUST00000113900.6 ENSMUST00000113900.7 S4A5_MOUSE uc291gen.1 uc291gen.2 Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. Reaction=2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in); Xref=Rhea:RHEA:72215, ChEBI:CHEBI:17544, ChEBI:CHEBI:29101; Evidence=; Reaction=3 hydrogencarbonate(out) + Na(+)(out) = 3 hydrogencarbonate(in) + Na(+)(in); Xref=Rhea:RHEA:72219, ChEBI:CHEBI:17544, ChEBI:CHEBI:29101; Evidence=; Apical cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Note=Localized predominantly to the basolateral sinusoidal membrane in hepatocytes. Belongs to the anion exchanger (TC 2.A.31) family. epithelial cell development renal system process regulation of systemic arterial blood pressure inorganic anion exchanger activity cell ion transport anion transport anion transmembrane transporter activity sodium:bicarbonate symporter activity regulation of gene expression inorganic anion transport bicarbonate transport membrane integral component of membrane cerebrospinal fluid secretion mitochondrion distribution regulation of intracellular pH retina development in camera-type eye anion transmembrane transport uc291gen.1 uc291gen.2 
ENSMUST00000113915.2 Klhl15 ENSMUST00000113915.2 Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits and regulating PP2A holoenzyme composition. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double- strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). (from UniProt A2AAX3) A2AAX3 AK133055 ENSMUST00000113915.1 KLH15_MOUSE Q3TEP6 Q8K1Y4 uc292plj.1 uc292plj.2 Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits and regulating PP2A holoenzyme composition. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double- strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). Protein modification; protein ubiquitination. Homodimer. Dimerization does not affect PPP2R5B-binding, but is required for its proteasomal degradation. Interacts with CUL3. Directly interacts with PPP2R5B; this interaction leads to PPP2R5B proteasomal degradation. Interacts with RBBP8/CtIP; this interaction leads to RBBP8 proteasomal degradation. Interacts with PACMP micropeptide; interaction prevents ubiquitination and degradation of RBBP8/CtIP. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AAX3-1; Sequence=Displayed; Name=2; IsoId=A2AAX3-2; Sequence=VSP_058696, VSP_058698; Name=3; IsoId=A2AAX3-3; Sequence=VSP_058695, VSP_058697; nucleus ubiquitin-dependent protein catabolic process protein ubiquitination Cul3-RING ubiquitin ligase complex nucleus-associated proteasomal ubiquitin-dependent protein catabolic process negative regulation of double-strand break repair via homologous recombination uc292plj.1 uc292plj.2 
ENSMUST00000113919.10 Dctn1 ENSMUST00000113919.10 dynactin 1, transcript variant 1 (from RefSeq NM_007835.3) DCTN1_MOUSE E9QLJ1 ENSMUST00000113919.1 ENSMUST00000113919.2 ENSMUST00000113919.3 ENSMUST00000113919.4 ENSMUST00000113919.5 ENSMUST00000113919.6 ENSMUST00000113919.7 ENSMUST00000113919.8 ENSMUST00000113919.9 NM_007835 O08788 Q3TZG7 uc009cnc.1 uc009cnc.2 uc009cnc.3 Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation (By similarity). Monomer and homodimer (By similarity). Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. DCTN1/p150(glued) binds directly to microtubules and to cytoplasmic dynein. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin (By similarity). Interacts with the C-terminus of MAPRE1, MAPRE2 and MAPRE3. Interacts with FBXL5. Interacts with ECPAS. Interacts with CLIP1. Interacts with CLN3 and DYNAP. Interacts with MISP; this interaction regulates its distribution at the cell cortex. Interacts with CEP131. Interacts with CEP126. Interacts with dynein intermediate chain and dynein heavy chain. Interacts with PLK1 (via POLO-box domain). Interacts with TBCB and PARD6A (By similarity). Binds preferentially to tyrosinated microtubules than to detyrosinated microtubules (PubMed:16954346). Interacts with KIF3A (PubMed:23386061). Interacts with HPS6 (PubMed:25189619). Interacts with SNX6 (PubMed:19935774). Interacts with BICD2 (PubMed:22956769). Interacts with DST (isoform 1) (PubMed:14581450). Identified in a complex with MREG and RILP (PubMed:22275436). Interacts with BCCIP. Interacts with DCDC1 (By similarity). Interacts with AKNA (PubMed:30787442). Interacts with DYNC1I2 (PubMed:27474409). O08788; Q6A078: Cep290; NbExp=2; IntAct=EBI-776180, EBI-1811999; O08788; P28741: Kif3a; NbExp=4; IntAct=EBI-776180, EBI-6169413; O08788; P33175: Kif5a; NbExp=2; IntAct=EBI-776180, EBI-349710; Cytoplasm Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle Nucleus envelope Cytoplasm, cell cortex Note=Localizes to microtubule plus ends. Localizes preferentially to the ends of tyrosinated microtubules (PubMed:16954346). Localization at centrosome is regulated by SLK- dependent phosphorylation. Localizes to centrosome in a PARKDA- dependent manner. PLK1-mediated phosphorylation at Ser-179 is essential for its localization in the nuclear envelope (By similarity). Localizes to the subdistal appendage region of the centriole in a KIF3A-dependent manner (PubMed:23386061). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O08788-1; Sequence=Displayed; Name=2; IsoId=O08788-2; Sequence=VSP_029584; The CAP-Gly domain is essential for interactions with microtubules and its binding partners and for its motion along the microtubules. Essential for its preferential binding to tyrosinated microtubules and for promoting the sustained interaction of the dynein motor with microtubules. Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome. Phosphorylation by SLK at Thr-145, Thr-146 and Thr-147 targets DCTN1 to the centrosome. It is uncertain if SLK phosphorylates all three threonines or one or two of them. PLK1-mediated phosphorylation at Ser-179 is essential for its localization in the nuclear envelope and promotes its dissociation from microtubules during early mitosis and positively regulates nuclear envelope breakdown during prophase. Belongs to the dynactin 150 kDa subunit family. establishment of mitotic spindle orientation kinetochore spindle pole motor activity protein binding nucleus nuclear envelope cytoplasm centrosome centriole microtubule organizing center spindle cytosol cytoskeleton cytoplasmic dynein complex microtubule microtubule associated complex cell cortex cell cycle neuromuscular junction development microtubule binding centriole-centriole cohesion transport along microtubule tubulin binding protein kinase binding ventral spinal cord development dynein complex positive regulation of microtubule polymerization cytoplasmic microtubule organization cell leading edge melanosome transport macromolecular complex microtubule anchoring at centrosome microtubule plus-end retrograde transport, endosome to Golgi identical protein binding neuron projection neuronal cell body intermediate filament cytoskeleton neuromuscular process nuclear envelope disassembly cell division regulation of mitotic spindle organization motor behavior neuron cellular homeostasis positive regulation of microtubule nucleation positive regulation of intracellular protein transport cell cortex region positive regulation of neuromuscular junction development non-motile cilium assembly neuron projection maintenance retromer complex uc009cnc.1 uc009cnc.2 uc009cnc.3 
ENSMUST00000113935.9 Ino80b ENSMUST00000113935.9 INO80 complex subunit B (from RefSeq NM_023547.2) A0A6Q6QAE5 A0A6Q6QAE5_MOUSE ENSMUST00000113935.1 ENSMUST00000113935.2 ENSMUST00000113935.3 ENSMUST00000113935.4 ENSMUST00000113935.5 ENSMUST00000113935.6 ENSMUST00000113935.7 ENSMUST00000113935.8 Ino80b NM_023547 uc291gdn.1 uc291gdn.2 uc291gdn.1 uc291gdn.2 
ENSMUST00000113936.10 Wbp1 ENSMUST00000113936.10 WW domain binding protein 1, transcript variant 3 (from RefSeq NM_001083923.1) ENSMUST00000113936.1 ENSMUST00000113936.2 ENSMUST00000113936.3 ENSMUST00000113936.4 ENSMUST00000113936.5 ENSMUST00000113936.6 ENSMUST00000113936.7 ENSMUST00000113936.8 ENSMUST00000113936.9 NM_001083923 P97764 Q8WUP5 Q99J20 WBP1_MOUSE uc009cmq.1 uc009cmq.2 uc009cmq.3 Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX (By similarity). Interacts with NEDD4. P97764; P46935: Nedd4; NbExp=3; IntAct=EBI-6304160, EBI-773516; P97764; P46937: YAP1; Xeno; NbExp=13; IntAct=EBI-6304160, EBI-1044059; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P97764-1; Sequence=Displayed; Name=2; IsoId=P97764-2; Sequence=VSP_004022; The PPxY motif 2 mediates interaction with WWOX (By similarity). Both PPxY motifs mediate interaction with NEDD4. protein binding cellular_component biological_process WW domain binding uc009cmq.1 uc009cmq.2 uc009cmq.3 
ENSMUST00000113938.5 Mrpl53 ENSMUST00000113938.5 mitochondrial ribosomal protein L53 (from RefSeq NM_026744.3) ENSMUST00000113938.1 ENSMUST00000113938.2 ENSMUST00000113938.3 ENSMUST00000113938.4 NM_026744 Q9D1H8 RM53_MOUSE uc291gde.1 uc291gde.2 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mL53 family. molecular_function mitochondrion mitochondrial large ribosomal subunit ribosome biological_process uc291gde.1 uc291gde.2 
ENSMUST00000113952.10 Wdr5 ENSMUST00000113952.10 WD repeat domain 5 (from RefSeq NM_080848.2) Big Big3 ENSMUST00000113952.1 ENSMUST00000113952.2 ENSMUST00000113952.3 ENSMUST00000113952.4 ENSMUST00000113952.5 ENSMUST00000113952.6 ENSMUST00000113952.7 ENSMUST00000113952.8 ENSMUST00000113952.9 NM_080848 P61965 Q91VA5 Q922C9 Q9NWX7 Q9UGP9 WDR5_MOUSE uc012bsw.1 uc012bsw.2 uc012bsw.3 uc012bsw.4 uc012bsw.5 Contributes to histone modification (By similarity). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). May regulate osteoblasts differentiation (PubMed:11551928). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity). Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3 (PubMed:22862948). Interacts with HCFC1 (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (By similarity). Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7 (PubMed:21335234). Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin (PubMed:21335234). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (By similarity). Interacts with KMT2A/MLL1 (via WIN motif) and RBBP5; the interaction is direct (By similarity). Component ofthe ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (By similarity). In the complex, it probably interacts directly with KAT2A, MBIP and KAT14 (By similarity). Interacts with histone H3 (By similarity). Interacts with SETD1A (via WIN motif) (By similarity). Component of a histone methylation complex composed of at least ZNF335, RBBP5, ASH2L and WDR5; the complex may have histone H3-specific methyltransferase activity, however does not have specificity for 'Lys-4' of histone H3 (By similarity). Interacts with ZNF335 (PubMed:23178126). Components of this complex may associate with components of the ZNF335-CCAR2-EMSY nuclear receptor-mediated transcription complex to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5 (By similarity). Interacts with PER1 (By similarity). Interacts with KMT2D (via WIN motif) (PubMed:21335234). Interacts with KMT2B (via WIN motif), KMT2C (via WIN motif) and SETD1B (via WIN motif) (By similarity). P61965; P20263: Pou5f1; NbExp=7; IntAct=EBI-1247084, EBI-1606219; Nucleus Expressed in liver (at protein level). Detected in brain, testis and kidney. Belongs to the WD repeat WDR5/wds family. histone acetyltransferase complex skeletal system development protein binding nucleus nucleoplasm Ada2/Gcn5/Ada3 transcription activator complex chromatin organization neuron projection development methylated histone binding histone methyltransferase complex positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter histone binding histone methyltransferase activity (H3-K4 specific) histone H3 acetylation histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) MLL3/4 complex histone acetyltransferase activity (H4-K16 specific) Set1C/COMPASS complex histone H3-K4 methylation MLL1 complex uc012bsw.1 uc012bsw.2 uc012bsw.3 uc012bsw.4 uc012bsw.5 
ENSMUST00000113955.2 Mageb18 ENSMUST00000113955.2 MAGE family member B18 (from RefSeq NM_173783.3) ENSMUST00000113955.1 MAGBI_MOUSE Mageb18 NM_173783 Q8BQR7 uc033jrh.1 uc033jrh.2 uc033jrh.3 May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Interacts with LNX1. Cytoplasm Expressed in testis, stomach, large intestine, small intestine, spleen, lymph node, bone marrow lymphocytes and blood T-lymphocytes. Not detected in brain, heart, lung, liver or kidney (at protein level). In the testis, expression is detected from the first day of birth, increases steadily in the first 3 weeks of life, decreases around day 28, increases at day 35 and is stable between 35 and 56 days. Highly expressed in spermatogonia and is also observed in primary and secondary spermatocytes but less so in spermatids (at protein level). molecular_function cytoplasm biological_process uc033jrh.1 uc033jrh.2 uc033jrh.3 
ENSMUST00000113958.2 Ppp4r3c2 ENSMUST00000113958.2 protein phosphatase 4 regulatory subunit 3C2 (from RefSeq NM_001085511.1) 4932429P05Rik A2ADI4 A2ADI4_MOUSE ENSMUST00000113958.1 NM_001085511 Ppp4r3c2 uc009tsh.1 uc009tsh.2 Belongs to the SMEK family. molecular_function cellular_component biological_process uc009tsh.1 uc009tsh.2 
ENSMUST00000113960.3 Dcaf8l ENSMUST00000113960.3 DDB1 and CUL4 associated factor 8 like (from RefSeq NM_008821.2) A2AHY8 A2AHY8_MOUSE Dcaf8l ENSMUST00000113960.1 ENSMUST00000113960.2 NM_008821 Pet2 uc012hlq.1 uc012hlq.2 Protein modification; protein ubiquitination. molecular_function cellular_component biological_process uc012hlq.1 uc012hlq.2 
ENSMUST00000113966.8 Il1rapl1 ENSMUST00000113966.8 interleukin 1 receptor accessory protein-like 1 (from RefSeq NM_001160403.2) B1ASU0 B1ASU0_MOUSE ENSMUST00000113966.1 ENSMUST00000113966.2 ENSMUST00000113966.3 ENSMUST00000113966.4 ENSMUST00000113966.5 ENSMUST00000113966.6 ENSMUST00000113966.7 Il1rapl1 NM_001160403 uc012hln.1 uc012hln.2 uc012hln.3 Cell membrane ; Single-pass type I membrane protein Cell projection, axon Cell projection, dendrite Cytoplasm Belongs to the interleukin-1 receptor family. plasma membrane signal transduction membrane integral component of membrane negative regulation of exocytosis glutamatergic synapse trans-synaptic signaling by trans-synaptic complex regulation of presynapse assembly uc012hln.1 uc012hln.2 uc012hln.3 
ENSMUST00000113973.8 Kmt5b ENSMUST00000113973.8 lysine methyltransferase 5B, transcript variant 1 (from RefSeq NM_001167885.1) ENSMUST00000113973.1 ENSMUST00000113973.2 ENSMUST00000113973.3 ENSMUST00000113973.4 ENSMUST00000113973.5 ENSMUST00000113973.6 ENSMUST00000113973.7 KMT5B_MOUSE Kmt5b NM_001167885 Q3U8K7 Q3UTP6 Q6DI74 Q6Q784 Q8BU67 Q8BUN0 Q8BUT7 Q8BW73 Q8BZ24 Q91X81 Suv420h1 uc008fxa.1 uc008fxa.2 uc008fxa.3 uc008fxa.4 Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:28114273, PubMed:24049080, PubMed:15145825). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (PubMed:15145825). Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions (PubMed:15145825). KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (PubMed:16612004, PubMed:15750587). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). Reaction=N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60348, Rhea:RHEA-COMP:15555, Rhea:RHEA- COMP:15556, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; EC=2.1.1.362; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60349; Evidence=; Reaction=N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L- methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61992, Rhea:RHEA- COMP:15556, Rhea:RHEA-COMP:15998, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961, ChEBI:CHEBI:61976; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61993; Evidence=; Reaction=L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60344, Rhea:RHEA-COMP:15554, Rhea:RHEA-COMP:15555, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.361; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60345; Evidence=; Inhibited by 6,7-Dichloro-N-cyclopentyl-4- (pyridin-4-yl)phthalazin-1-amine (A-196). A-196 is competitive with the histone peptide substrate H4K20me1 but non competitive with S-adenosyl- L-methionine. Kinetic parameters: KM=46 uM for histone H4K20me1 peptide ; Homodimer (PubMed:24049080). Interacts with HP1 proteins CBX1, CBX3 and CBX5 (PubMed:15145825). Interacts with RB1 family proteins RB1, RBL1 and RBL2 (PubMed:15750587, PubMed:16612004). Interacts (via C-terminus) with FRG1 (PubMed:23720823). Nucleus Chromosome Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q3U8K7-1; Sequence=Displayed; Name=2; IsoId=Q3U8K7-2; Sequence=VSP_024055, VSP_024056; Name=3; IsoId=Q3U8K7-3; Sequence=VSP_024053; Name=4; IsoId=Q3U8K7-4; Sequence=VSP_024054; Name=5; IsoId=Q3U8K7-5; Sequence=VSP_024053, VSP_024057; Partial muscle-specific knockout mice display several signs of muscular dystrophy including necrosis and an increased number of centrally nucleated myofibers. RNAi-mediated knockdown in C2C12 muscle cells causes reduced myogenic differentiation of the cells. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily. Sequence=AAH11214.1; Type=Erroneous initiation; Evidence=; Sequence=AAT00539.1; Type=Erroneous initiation; Evidence=; Sequence=BAC39834.1; Type=Erroneous initiation; Evidence=; Sequence=BAE23934.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; condensed nuclear chromosome, centromeric region nucleus chromosome chromatin organization muscle organ development methyltransferase activity histone methylation transferase activity histone-lysine N-methyltransferase activity methylation histone H4-K20 trimethylation histone methyltransferase activity (H4-K20 specific) uc008fxa.1 uc008fxa.2 uc008fxa.3 uc008fxa.4 
ENSMUST00000113975.3 Slc5a3 ENSMUST00000113975.3 solute carrier family 5 (inositol transporters), member 3 (from RefSeq NM_017391.3) B2RU60 ENSMUST00000113975.1 ENSMUST00000113975.2 NM_017391 Q9JKZ2 SC5A3_MOUSE uc007zyt.1 uc007zyt.2 uc007zyt.3 Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (PubMed:12582158, PubMed:24595108). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (PubMed:24595108) (By similarity). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (PubMed:24595108). Associates with KCNQ2- KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (By similarity). Provides myo- inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide- dependent ion channels and Ca(2+) signaling upon osmotic stress (By similarity). (Microbial infection) Functions as a retroviral receptor for M813 murine leukemia virus (MuLV) entry. Reaction=myo-inositol(out) + 2 Na(+)(out) = myo-inositol(in) + 2 Na(+)(in); Xref=Rhea:RHEA:72987, ChEBI:CHEBI:17268, ChEBI:CHEBI:29101; Evidence=; Reaction=2 Na(+)(out) + scyllo-inositol(out) = 2 Na(+)(in) + scyllo- inositol(in); Xref=Rhea:RHEA:72991, ChEBI:CHEBI:10642, ChEBI:CHEBI:29101; Evidence=; Interacts with KCNQ2 (via the pore module) (By similarity). Interacts with KCNQ1; this interaction is direct (PubMed:24595108). Forms coregulatory complexes with ion channels KCNQ2-KCNQ3 and KCNQ1- KCNE2 (PubMed:24595108) (By similarity). Apical cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Note=Colocalizes with KCNQ1 at the apical membrane of choroid plexus epithelium. Highly expressed in kidney, placenta, and brain and at a lesser extent in thymus, lung, bladder, and testes (PubMed:12582158). Expressed in the choroid plexus epithelium (at protein level) (PubMed:24595108). Expressed in placenta at 14.5 dpc. Mutant embryos show brain myo-inositol deficiency and central apnea and die soon after birth due to hypoventilation. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. glucose:sodium symporter activity plasma membrane inositol metabolic process ion transport sodium ion transport peripheral nervous system development symporter activity myo-inositol transport membrane integral component of membrane transmembrane transporter activity regulation of respiratory gaseous exchange transmembrane transport glucose transmembrane transport uc007zyt.1 uc007zyt.2 uc007zyt.3 
ENSMUST00000113976.2 Tasl ENSMUST00000113976.2 TLR adaptor interacting with endolysosomal SLC15A4 (from RefSeq NM_001163539.1) ENSMUST00000113976.1 NM_001163539 Q9D3J9 TASL_MOUSE Tasl uc009tsa.1 uc009tsa.2 uc009tsa.3 uc009tsa.4 Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons. Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes. Interacts (via pLxIS motif) with IRF5; leading to IRF5 activation. Interacts with SLC15A4; leading to its recruitment to endolysosome. Lysosome membrane Endosome membrane Nucleus Cytoplasm Note=Recruited to endolysosome following interaction with SLC15A4. May colocalize with TLR7 in the endosomal pathway. The pLxIS motif constitutes an IRF5-binding motif: following phosphorylation, the phosphorylated pLxIS motif of TASL recruits IRF5. The phosphorylated pLxIS motif constitutes an IRF5-binding motif, leading to recruitment of the transcription factor IRF5 to induce type- I interferons and other cytokines. molecular_function cellular_component cell biological_process regulation of lysosomal lumen pH uc009tsa.1 uc009tsa.2 uc009tsa.3 uc009tsa.4 
ENSMUST00000113978.9 Gk ENSMUST00000113978.9 glycerol kinase, transcript variant 5 (from RefSeq NM_001331046.1) B1ASZ1 ENSMUST00000113978.1 ENSMUST00000113978.2 ENSMUST00000113978.3 ENSMUST00000113978.4 ENSMUST00000113978.5 ENSMUST00000113978.6 ENSMUST00000113978.7 ENSMUST00000113978.8 GLPK_MOUSE Gk Gyk NM_001331046 Q64516 Q8C2M1 Q8C8X0 uc009trx.1 uc009trx.2 uc009trx.3 Kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Sn- glycerol 3-phosphate is a crucial intermediate in various metabolic pathways, such as the synthesis of glycerolipids and triglycerides, glycogenesis, glycolysis and gluconeogenesis. Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216; EC=2.7.1.30; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21645; Evidence=; Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. Mitochondrion outer membrane ; Single-pass membrane protein Nucleus Cytoplasm, cytosol Note=Glycerol kinase activity is more cytosolic in some tissues. It probably represents the expression of isoforms lacking a transmembrane domain. [Isoform 3]: Mitochondrion outer membrane ; Single-pass membrane protein Nucleus [Isoform 1]: Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q64516-3; Sequence=Displayed; Name=2; IsoId=Q64516-2; Sequence=VSP_034650; Name=1; Synonyms=Gyk-EX18 ; IsoId=Q64516-1; Sequence=VSP_034650, VSP_034651; [Isoform 1]: The sole isoform expressed in adult liver, newborn liver, and newborn brown fat. Belongs to the FGGY kinase family. nucleotide binding glycerol kinase activity ATP binding nucleus cytoplasm mitochondrion mitochondrial outer membrane cytosol carbohydrate metabolic process glycerol metabolic process glycerol-3-phosphate metabolic process triglyceride metabolic process membrane kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor regulation of fatty acid metabolic process glycerol catabolic process histone binding glucose homeostasis response to ethanol glycerol-3-phosphate biosynthetic process uc009trx.1 uc009trx.2 uc009trx.3 
ENSMUST00000113979.10 Lancl1 ENSMUST00000113979.10 LanC (bacterial lantibiotic synthetase component C)-like 1, transcript variant 1 (from RefSeq NM_001190985.1) ENSMUST00000113979.1 ENSMUST00000113979.2 ENSMUST00000113979.3 ENSMUST00000113979.4 ENSMUST00000113979.5 ENSMUST00000113979.6 ENSMUST00000113979.7 ENSMUST00000113979.8 ENSMUST00000113979.9 Gpr69a LANC1_MOUSE Lancl1 NM_001190985 O89112 uc007biw.1 uc007biw.2 uc007biw.3 Functions as a glutathione transferase (PubMed:25158856). Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate (PubMed:25158856). Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (PubMed:25158856). May play a role in EPS8 signaling. Binds glutathione (By similarity). Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Reaction=1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl- S-glutathione + chloride + H(+); Xref=Rhea:RHEA:51220, ChEBI:CHEBI:15378, ChEBI:CHEBI:17996, ChEBI:CHEBI:34718, ChEBI:CHEBI:57925, ChEBI:CHEBI:133977; EC=2.5.1.18; Evidence=; Kinetic parameters: KM=1.93 mM for 1-chloro-2,4-dinitrobenzene ; Vmax=1087 nmol/min/mg enzyme ; Interacts with the C-terminal of STOM (By similarity). Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding (By similarity). Cytoplasm Cell membrane ; Peripheral membrane protein Detected in spinal cord (at protein level). Ubiquitous. Strongly expressed in brain, testis, alveolar macrophages and epithelial cells of the lung, kidney and intestine (PubMed:17305318, PubMed:9714732). Expression in brain increases during the first postnatal month and remaining high in adult (PubMed:25158856). Induced by oxidative stress. Knockout mice are viable. During later postnatal development, mice demonstrate prominent neuronal degeneration. Was originally thought to be a G-protein coupled receptor. Belongs to the LanC-like protein family. catalytic activity glutathione transferase activity cytoplasm plasma membrane zinc ion binding membrane transferase activity SH3 domain binding glutathione binding regulation of neuron apoptotic process metal ion binding low-density lipoprotein particle receptor binding regulation of oxidative stress-induced neuron death integral component of plasma membrane G-protein coupled receptor signaling pathway uc007biw.1 uc007biw.2 uc007biw.3 
ENSMUST00000113980.4 M1ap ENSMUST00000113980.4 meiosis 1 associated protein (from RefSeq NM_033079.2) D6Mm5e ENSMUST00000113980.1 ENSMUST00000113980.2 ENSMUST00000113980.3 M1AP_MOUSE NM_033079 Q3V2A0 Q9Z0E1 Spata37 uc009clp.1 uc009clp.2 uc009clp.3 uc009clp.4 Required for meiosis I progression during spermatogenesis. Cytoplasm Expressed in germ cells of the testis. Expressed from spermatogonia to spermatids. Expressed at very low levels in lung, stomach, thymus. Not detected in Sertoli cells. Germ cell-specific, but may also be expressed in cells that require the presence of germ cells. Cranial to caudal punctate expression is seen in the developing ovary starting at 13.5 dpc. At 13.5 dpc. expressed in the cranial part of the XX gonad. At 14.5 dpc, expression extends to almost two-thirds of the XX gonad, and by 15.5 dpc expression is seen throughout the entire organ. By 16.5 dpc, expression is only detected in the most caudal tip of the XX gonad. Expression switches from the embryonic ovary to the postnatal testis. Males show reduced testicular size and a tubular defects, which led to severe oligozoospermia and infertility. Spermatocytes are eliminated via apoptosis either at the pachytene checkpoint, or later at the spindle checkpoint during metaphase I. Seems to synergize with Cbfb and Myh11 during the onset of acute myeloid leukemia. molecular_function cytoplasm RNA processing meiosis I spermatogenesis female gamete generation integral component of membrane cell differentiation chromatin assembly identical protein binding male meiosis chromosome separation uc009clp.1 uc009clp.2 uc009clp.3 uc009clp.4 
ENSMUST00000113997.9 Ppp6r3 ENSMUST00000113997.9 protein phosphatase 6, regulatory subunit 3, transcript variant 1 (from RefSeq NM_028999.1) ENSMUST00000113997.1 ENSMUST00000113997.2 ENSMUST00000113997.3 ENSMUST00000113997.4 ENSMUST00000113997.5 ENSMUST00000113997.6 ENSMUST00000113997.7 ENSMUST00000113997.8 G5E8R4 G5E8R4_MOUSE NM_028999 Ppp6r3 uc012bfw.1 uc012bfw.2 uc012bfw.3 uc012bfw.4 uc012bfw.5 Belongs to the SAPS family. nucleoplasm cytosol plasma membrane protein phosphatase binding regulation of phosphoprotein phosphatase activity uc012bfw.1 uc012bfw.2 uc012bfw.3 uc012bfw.4 uc012bfw.5 
ENSMUST00000114000.8 Dmd ENSMUST00000114000.8 dystrophin, muscular dystrophy, transcript variant 1 (from RefSeq NM_007868.6) A2A9Z0 DMD_MOUSE ENSMUST00000114000.1 ENSMUST00000114000.2 ENSMUST00000114000.3 ENSMUST00000114000.4 ENSMUST00000114000.5 ENSMUST00000114000.6 ENSMUST00000114000.7 NM_007868 O35653 P11531 Q60703 uc009tri.1 uc009tri.2 uc009tri.3 uc009tri.4 This gene encodes a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers in skeletal and cardiac muscles. The encoded protein, dystrophin, is part of the dystrophin-glycoprotein complex, which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix. This protein is required for proper development and organization of myofibers as contractile units in striated muscles. Mutations in the human gene cause Duchenne and Becker Muscular Dystrophies and a form of heart disease called DMD-associated dilated cardiomyopathy. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]. Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. Interacts with SYNM (PubMed:16777071). Interacts with the syntrophins SNTG1 and SNTG2. Interacts with KRT19. Component of the dystrophin-associated glycoprotein complex which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex. Interacts with DAG1 (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif of DAG1 (By similarity). Interacts with SYNM; SNTA1 and SNTB1. Interacts with CMYA5 (PubMed:20634290). Directly interacts with ANK2 and ANK3; these interactions do not interfere with betaDAG1-binding and are necessary for proper localization in muscle cells (PubMed:19109891). Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (PubMed:11430802). Interacts with DTNB (PubMed:10893187). Interacts with PGM5; the interaction is direct (PubMed:7890770). Interacts with NOS1; localizes NOS1 to sarcolemma in muscle cells (PubMed:7545544). P11531; Q9CZA6-1: Nde1; NbExp=2; IntAct=EBI-295928, EBI-15949673; P11531; Q61234: Snta1; NbExp=4; IntAct=EBI-295928, EBI-295952; Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Postsynaptic cell membrane Note=In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs). In adult muscle, NMJ localization depends upon ANK2 presence, but not in newborn animals. Event=Alternative splicing; Named isoforms=1; Comment=At least 11 isoforms are produced.; Name=1; IsoId=P11531-1; Sequence=Displayed; Detected in quadriceps muscle and in sciatic nerve (at protein level) (PubMed:11430802). Differentially expressed during skeletal muscle, heart, and brain development. Also expressed in retina (PubMed:7633443). Mutant mice show reduced contractile force compared to wild-types, at least for soleus muscle. They have decreased motor activity levels after exercise, increased muscle permeability and fibrosis with impaired regeneration (PubMed:28498977). MEGF10 and DMD double knockout animals have pronounced fiber size variability and intracellular inclusions in the quadriceps femoris with extensive endomysial connective tissue infiltration. Mice develop muscle weakness, kyphosis and a waddling gait. At 2 months of age, they have reduced contractile force compared to wild-type mice. They display reduced motor activity after exercise and they walk shorter distances than wild-type. They have a delayed regeneration after muscle injury and an aberrant muscle fiber typing and cross-sectional areas (PubMed:28498977). positive regulation of cell-matrix adhesion regulation of heart rate dystroglycan binding actin binding integrin binding protein binding lamin binding nucleus cytoplasm mitochondrial outer membrane Golgi apparatus ribosome cytoskeleton neurofilament plasma membrane regulation of transcription, DNA-templated muscle organ development skeletal muscle tissue development aging establishment of blood-nerve barrier zinc ion binding positive regulation of cell proliferation structural constituent of muscle response to water deprivation cell surface regulation of gene expression regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of neuron projection development postsynaptic density regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion regulation of skeletal muscle contraction response to denervation involved in regulation of muscle adaptation myotube cell development dystrophin-associated glycoprotein complex membrane myosin binding vinculin binding olfactory nerve structural organization cerebral cortex development myofibril Z disc lamellipodium cell junction cell-substrate junction secretory granule cell differentiation PDZ domain binding filopodium neuron differentiation axon synaptic vesicle membrane filopodium membrane macromolecular complex negative regulation of peptidyl-serine phosphorylation cellular protein localization cellular macromolecular complex assembly response to muscle stretch sarcolemma regulation of membrane potential muscle cell differentiation cell projection neuron projection neuronal cell body costamere peptide biosynthetic process skeletal muscle tissue regeneration neuron projection terminus macromolecular complex binding membrane raft synapse postsynaptic membrane neurotransmitter receptor metabolic process negative regulation of neuron differentiation positive regulation of neuron differentiation muscle cell cellular homeostasis metal ion binding perinuclear region of cytoplasm muscle fiber development neuron projection morphogenesis nitric-oxide synthase binding nucleus localization regulation of cell cycle cardiac muscle contraction regulation of ryanodine-sensitive calcium-release channel activity establishment of glial blood-brain barrier negative regulation of ERK1 and ERK2 cascade cardiac muscle cell action potential regulation of cellular response to growth factor stimulus astrocyte projection matrix side of mitochondrial inner membrane regulation of voltage-gated calcium channel activity negative regulation of peptidyl-cysteine S-nitrosylation positive regulation of sodium ion transmembrane transporter activity uc009tri.1 uc009tri.2 uc009tri.3 uc009tri.4 
ENSMUST00000114007.8 Cacfd1 ENSMUST00000114007.8 Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling (PubMed:22362363, PubMed:29288152). In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin- mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (By similarity). In cytotoxic T-lymphoocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules (CGs) at the immuno synapse (PubMed:29288152). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process (PubMed:22362363). (from UniProt Q8BG21) A2AR22 A2AR23 A6PWX1 AK039867 ENSMUST00000114007.1 ENSMUST00000114007.2 ENSMUST00000114007.3 ENSMUST00000114007.4 ENSMUST00000114007.5 ENSMUST00000114007.6 ENSMUST00000114007.7 FLOWR_MOUSE Q8BG21 Q8C9W0 Q8CC30 Q9CX69 uc008iwt.1 uc008iwt.2 uc008iwt.3 uc008iwt.4 Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling (PubMed:22362363, PubMed:29288152). In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin- mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (By similarity). In cytotoxic T-lymphoocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules (CGs) at the immuno synapse (PubMed:29288152). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process (PubMed:22362363). Interacts with adaptor protein complex 2 (AP-2). Cell membrane ; Multi-pass membrane protein Vesicle Note=In cytotoxic T-lymphoocytes, localizes to intracellular vesicles that move to the immuno synapse (PubMed:29288152). Enriched in synaptic vesicles at the presynpatic vesicles (By similarity). Detected in the Golgi apparatus of cultured hippocampal neurons (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Fwe2 ; IsoId=Q8BG21-1; Sequence=Displayed; Name=2; Synonyms=Fwe3 ; IsoId=Q8BG21-2; Sequence=VSP_012998, VSP_012999; Name=3; Synonyms=Fwe1 ; IsoId=Q8BG21-3; Sequence=VSP_013000; Name=4; Synonyms=Fwe4 ; IsoId=Q8BG21-4; Sequence=VSP_062136; Expressed in neurons in the brain (at protein level) (PubMed:29288152). Expressed in neuroblastoma cell lines (at protein level) (PubMed:28414717). Expressed in cytotoxic T-lymphoocytes (at protein level) (PubMed:29288152). [Isoform 1]: Low levels of expression in various tissues including the brain, eye, heart, liver and colon (PubMed:22362363). Expression in the heart is at slightly higher levels than isoform 3 (PubMed:22362363). Expressed in skin cells (PubMed:22362363). [Isoform 2]: Very low levels of expression in the brain, liver and eye (PubMed:22362363). Detected at very low levels of expression in skin cells (PubMed:22362363). [Isoform 3]: Expressed in various tissues, with highest levels of expression in the brain and eye (PubMed:22362363). Expressed in skin cells (PubMed:22362363). Low levels of expression in the liver, colon, heart and spleen (PubMed:22362363). [Isoform 4]: Barely detected in the brain and liver. Expressed in postnatal and adult brain (at protein level). Increased expression in stimulated cytotoxic T-lymphoocytes. Viable and fertile (PubMed:22362363). Results in lowered susceptibility to skin papillomas induced by 7,12- dimethylbenzanthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) (PubMed:22362363). In cytotoxic T-lymphoocytes, leads to a complete block of early cytotoxic granules (CG) endocytosis at the immuno synapse thereby impairing serial killing of target cells (PubMed:29288152). Does not affect cytotoxic granules exocytosis and global calcium signaling, however increases latency of CG fusion and endosome recycling (PubMed:29288152). In chemically-induced skin papilloma, isoforms 1 and 3 are up-regulated in the papilloma cells and papilloma-surrounding skin, suggesting they might be important for papilloma growth. Belongs to the calcium channel flower family. molecular_function cellular_component membrane integral component of membrane vesicle-mediated transport uc008iwt.1 uc008iwt.2 uc008iwt.3 uc008iwt.4 
ENSMUST00000114011.11 Lsm2 ENSMUST00000114011.11 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated, transcript variant 4 (from RefSeq NM_001204274.1) ENSMUST00000114011.1 ENSMUST00000114011.10 ENSMUST00000114011.2 ENSMUST00000114011.3 ENSMUST00000114011.4 ENSMUST00000114011.5 ENSMUST00000114011.6 ENSMUST00000114011.7 ENSMUST00000114011.8 ENSMUST00000114011.9 Lsm2 NM_001204274 Q3U9X2 Q3U9X2_MOUSE uc008cer.1 uc008cer.2 uc008cer.3 uc008cer.4 uc008cer.5 uc008cer.6 Binds specifically to the 3'-terminal U-tract of U6 snRNA. Nucleus Belongs to the snRNP Sm proteins family. mRNA splicing, via spliceosome RNA binding nucleus spliceosomal complex U6 snRNP mRNA processing RNA splicing U4/U6 x U5 tri-snRNP complex uc008cer.1 uc008cer.2 uc008cer.3 uc008cer.4 uc008cer.5 uc008cer.6 
ENSMUST00000114017.8 Map2 ENSMUST00000114017.8 microtubule-associated protein 2, transcript variant 1 (from RefSeq NM_001039934.1) ENSMUST00000114017.1 ENSMUST00000114017.2 ENSMUST00000114017.3 ENSMUST00000114017.4 ENSMUST00000114017.5 ENSMUST00000114017.6 ENSMUST00000114017.7 Map2 Mtap2 NM_001039934 Q3TLQ0 Q3TLQ0_MOUSE uc007bhw.1 uc007bhw.2 uc007bhw.3 Cytoplasm, cytoskeleton microtubule bundle formation cytoplasm cytoskeleton microtubule microtubule binding tubulin binding central nervous system neuron development uc007bhw.1 uc007bhw.2 uc007bhw.3 
ENSMUST00000114024.9 Prrg1 ENSMUST00000114024.9 proline rich Gla (G-carboxyglutamic acid) 1, transcript variant 1 (from RefSeq NM_027322.2) A2BFE8 A2BFE8_MOUSE ENSMUST00000114024.1 ENSMUST00000114024.2 ENSMUST00000114024.3 ENSMUST00000114024.4 ENSMUST00000114024.5 ENSMUST00000114024.6 ENSMUST00000114024.7 ENSMUST00000114024.8 NM_027322 Prrg1 uc012hlj.1 uc012hlj.2 uc012hlj.3 uc012hlj.4 molecular_function calcium ion binding cellular_component extracellular region biological_process membrane integral component of membrane uc012hlj.1 uc012hlj.2 uc012hlj.3 uc012hlj.4 
ENSMUST00000114026.3 Gm14743 ENSMUST00000114026.3 predicted gene 14743 (from RefSeq NM_001126321.2) A2BHD2 A2BHD2_MOUSE ENSMUST00000114026.1 ENSMUST00000114026.2 Gm14743 NM_001126321 uc012hlh.1 uc012hlh.2 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc012hlh.1 uc012hlh.2 
ENSMUST00000114030.3 Gm5938 ENSMUST00000114030.3 predicted gene 5938 (from RefSeq NM_001085534.2) A2AEN9 A2AEN9_MOUSE ENSMUST00000114030.1 ENSMUST00000114030.2 Gm5938 NM_001085534 uc009tqv.1 uc009tqv.2 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc009tqv.1 uc009tqv.2 
ENSMUST00000114037.9 Son ENSMUST00000114037.9 Son DNA binding protein, transcript variant 1 (from RefSeq NM_178880.4) E3WC91 E9PXW2 E9Q3H8 E9Q3I0 E9Q6M4 E9Q7G2 E9QAR8 E9QMT0 ENSMUST00000114037.1 ENSMUST00000114037.2 ENSMUST00000114037.3 ENSMUST00000114037.4 ENSMUST00000114037.5 ENSMUST00000114037.6 ENSMUST00000114037.7 ENSMUST00000114037.8 NM_178880 Nrebp Q811G3 Q9CQ12 Q9CQK6 Q9QX47 Q9QXP5 SON_MOUSE uc007zxz.1 uc007zxz.2 uc007zxz.3 RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3' (By similarity). Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (By similarity). May also regulate the ghrelin signaling in hypothalamic neuron by acting as a negative regulator of GHSR expression (PubMed:20876580). Interacts with SRSF2. Associates with the spliceosome. Interacts with USH1G. Q9QX47; Q06455: RUNX1T1; Xeno; NbExp=4; IntAct=EBI-643037, EBI-743342; Nucleus speckle Note=Colocalizes with the pre-mRNA splicing factor SRSF2. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9QX47-1; Sequence=Displayed; Name=2; IsoId=Q9QX47-2; Sequence=VSP_004416, VSP_004417; Name=3; IsoId=Q9QX47-3; Sequence=VSP_041557; Name=4; IsoId=Q9QX47-4; Sequence=VSP_041557, VSP_041558; Widely expressed. Highly expressed in brain, heart, spleen, liver, skeletal muscle, kidney and testis. By leptin. Highly expressed in hypothalamus following leptin injection. Contains 8 types of repeats which are distributed in 3 regions. Sequence=AAH46419.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; microtubule cytoskeleton organization mitotic cytokinesis nucleic acid binding DNA binding RNA binding protein binding nucleus mRNA processing cell cycle RNA splicing nuclear speck negative regulation of apoptotic process regulation of RNA splicing regulation of mRNA splicing, via spliceosome RS domain binding regulation of cell cycle uc007zxz.1 uc007zxz.2 uc007zxz.3 
ENSMUST00000114039.3 Gm14744 ENSMUST00000114039.3 predicted gene 14744 (from RefSeq NM_001085544.1) 5430402E10Rik B1AVU4 B1AVU4_MOUSE ENSMUST00000114039.1 ENSMUST00000114039.2 Gm14744 NM_001085544 uc009tqs.1 uc009tqs.2 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc009tqs.1 uc009tqs.2 
ENSMUST00000114048.2 Tmsb10 ENSMUST00000114048.2 thymosin beta 10, transcript variant 1 (from RefSeq NM_001190327.1) ENSMUST00000114048.1 NM_001190327 Ptmb10 Q3V2M3 Q6ZWY8 TYB10_MOUSE uc012enk.1 uc012enk.2 uc012enk.3 Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). Cytoplasm, cytoskeleton Belongs to the thymosin beta family. actin binding actin monomer binding cytoplasm cytoskeleton actin filament organization actin cytoskeleton organization regulation of cell migration sequestering of actin monomers uc012enk.1 uc012enk.2 uc012enk.3 
ENSMUST00000114051.4 Gm15402 ENSMUST00000114051.4 Gm15402 (from geneSymbol) AK053994 ENSMUST00000114051.1 ENSMUST00000114051.2 ENSMUST00000114051.3 uc009cjc.1 uc009cjc.2 uc009cjc.3 uc009cjc.1 uc009cjc.2 uc009cjc.3 
ENSMUST00000114054.3 Cldn34d ENSMUST00000114054.3 claudin 34D (from RefSeq NM_001201395.1) A2AGU5 A2AGU5_MOUSE Cldn34d ENSMUST00000114054.1 ENSMUST00000114054.2 NM_001201395 uc012hlf.1 uc012hlf.2 uc012hlf.3 Cell junction, tight junction Belongs to the claudin family. molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc012hlf.1 uc012hlf.2 uc012hlf.3 
ENSMUST00000114059.10 Pls3 ENSMUST00000114059.10 plastin 3 (T-isoform), transcript variant 2 (from RefSeq NM_001166453.1) B1AX56 ENSMUST00000114059.1 ENSMUST00000114059.2 ENSMUST00000114059.3 ENSMUST00000114059.4 ENSMUST00000114059.5 ENSMUST00000114059.6 ENSMUST00000114059.7 ENSMUST00000114059.8 ENSMUST00000114059.9 NM_001166453 PLST_MOUSE Q3TUZ5 Q99K51 uc009tqk.1 uc009tqk.2 uc009tqk.3 uc009tqk.4 Actin-bundling protein. Monomer. Cytoplasm actin binding calcium ion binding cytoplasm cytosol actin filament plasma membrane neuromuscular junction stereocilium actin filament bundle metal ion binding actin filament binding actin filament bundle assembly actin filament network formation bone development uc009tqk.1 uc009tqk.2 uc009tqk.3 uc009tqk.4 
ENSMUST00000114069.8 Elmod3 ENSMUST00000114069.8 ELMO/CED-12 domain containing 3, transcript variant 1 (from RefSeq NM_144917.5) ELMD3_MOUSE ENSMUST00000114069.1 ENSMUST00000114069.2 ENSMUST00000114069.3 ENSMUST00000114069.4 ENSMUST00000114069.5 ENSMUST00000114069.6 ENSMUST00000114069.7 NM_144917 Q3TNV2 Q91YP6 Rbed1 uc009ciu.1 uc009ciu.2 uc009ciu.3 uc009ciu.4 Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity. Cell projection, stereocilium Cell projection, kinocilium Cytoplasm, cytoskeleton Note=Also present in the cuticular plate of auditory hair cells. In the organ of Corti, in inner hair cells, expressed along the length of the stereocilia, but excluded from the very tip. Colocalizes with F-actin cytoskeleton. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=b/c; IsoId=Q91YP6-1; Sequence=Displayed; Name=2; Synonyms=a; IsoId=Q91YP6-2; Sequence=VSP_022925, VSP_022926; Both isoform 1 and isoform 2 are widely expressed. Both isoform 1 and isoform 2 are expressed postnatally in the inner ear. Expression increases from P0 to P30 in both cochlear and vestibular tissues; at all time points, isoform 2 is expressed at several-fold higher levels than isoform 1. At P14, in the organ of Corti, detected along the length of stereocilia of hair cells, particularly in the upper half. Also observed in the microvilli on the apical surface of the hair cells. More abundant in the stereocilia of inner hair cells than in those of outer hair cells (at protein level). In the vestibular sensory epithelium, localizes within the hair cell and supporting cell bodies in the saccule and utricule. Not detected in vestibular hair bundles (at protein level). molecular_function cellular_component cytoplasm cytoskeleton cilium biological_process stereocilium cell projection positive regulation of GTPase activity kinocilium GTPase activator activity uc009ciu.1 uc009ciu.2 uc009ciu.3 uc009ciu.4 
ENSMUST00000114076.2 Epcip ENSMUST00000114076.2 exosomal polycystin 1 interacting protein, transcript variant 2 (from RefSeq NM_001163695.2) CU062_MOUSE ENSMUST00000114076.1 NM_001163695 Q544A2 Q9D4G1 uc007zxd.1 uc007zxd.2 Likely to be involved with PKD1 in the detection, sequestration and exocytosis of senescent mitochondria. Homooligomer. Interacts with PKD1 (via the PKD repeats in the N-terminal extracellular region); the interaction is not dependent on N-glycosylation of either protein. Vesicle Secreted, extracellular exosome Note=Detected on migrasomes and on extracellular exosomes in blood and urine. Low expression in liver, three times higher in kidney and abundant in testis. N-glycosylated. molecular_function cellular_component biological_process uc007zxd.1 uc007zxd.2 
ENSMUST00000114079.9 Mettl21a ENSMUST00000114079.9 methyltransferase 21A, HSPA lysine, transcript variant 3 (from RefSeq NM_001368284.1) ENSMUST00000114079.1 ENSMUST00000114079.2 ENSMUST00000114079.3 ENSMUST00000114079.4 ENSMUST00000114079.5 ENSMUST00000114079.6 ENSMUST00000114079.7 ENSMUST00000114079.8 Fam119a MT21A_MOUSE Mettl21A NM_001368284 Q8R2Y7 Q9CQL0 uc007bgv.1 uc007bgv.2 uc007bgv.3 Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8. Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54193; Evidence=; Interacts with heat shock 70 family members; at least some of these proteins are methylation substrates. Cytoplasm Belongs to the methyltransferase superfamily. METTL21 family. cytoplasm protein methylation methyltransferase activity protein methyltransferase activity protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine methylation Hsp70 protein binding heat shock protein binding methylation macromolecular complex ATPase binding uc007bgv.1 uc007bgv.2 uc007bgv.3 
ENSMUST00000114082.9 Sec16a ENSMUST00000114082.9 Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17428803). Mediates the recruitment of MIA3/TANGO to ERES. Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (By similarity). Acts as a RAB10 effector in the regulation of insulin- induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in adipocytes (PubMed:27354378). (from UniProt E9QAT4) A2AIX1 BC059898 E9QAT4 ENSMUST00000114082.1 ENSMUST00000114082.2 ENSMUST00000114082.3 ENSMUST00000114082.4 ENSMUST00000114082.5 ENSMUST00000114082.6 ENSMUST00000114082.7 ENSMUST00000114082.8 Kiaa0310 Q80U43 Q811L5 SC16A_MOUSE Sec16 uc008ivh.1 uc008ivh.2 uc008ivh.3 Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17428803). Mediates the recruitment of MIA3/TANGO to ERES. Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (By similarity). Acts as a RAB10 effector in the regulation of insulin- induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in adipocytes (PubMed:27354378). SEC16A and SEC16B are each present in multiple copies in a heteromeric complex (By similarity). Interacts with SEC23A (PubMed:17428803). Interacts with RNF183, RNF152, MIA3 and SEC13 (By similarity). Interacts with GORASP2 in response to ER stress (By similarity). Interacts with LRRK2 (via ROC domain) (PubMed:25201882). Interacts with RAB10 (PubMed:27354378). Endoplasmic reticulum membrane ; Peripheral membrane protein. Golgi apparatus membrane ; Peripheral membrane protein Cytoplasm, perinuclear region Cytoplasm, cytosol Microsome membrane Note=SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation (By similarity). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). MIA3 and LRRK2 are required for its proper localization to ERES (PubMed:25201882). Recruited to microsomal membrane in SAR1-dependent manner (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9QAT4-1; Sequence=Displayed; Name=2; IsoId=E9QAT4-2; Sequence=VSP_059936; Belongs to the SEC16 family. Golgi membrane protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol ER to Golgi vesicle-mediated transport endoplasmic reticulum organization Golgi organization ER to Golgi transport vesicle membrane protein transport membrane vesicle-mediated transport organelle membrane protein exit from endoplasmic reticulum response to endoplasmic reticulum stress Golgi to plasma membrane CFTR protein transport intracellular membrane-bounded organelle COPII vesicle coating perinuclear region of cytoplasm protein stabilization positive regulation of protein exit from endoplasmic reticulum endoplasmic reticulum exit site protein localization to endoplasmic reticulum exit site protein localization to plasma membrane uc008ivh.1 uc008ivh.2 uc008ivh.3 
ENSMUST00000114086.8 Klf7 ENSMUST00000114086.8 Kruppel-like transcription factor 7 (ubiquitous) (from RefSeq NM_033563.2) ENSMUST00000114086.1 ENSMUST00000114086.2 ENSMUST00000114086.3 ENSMUST00000114086.4 ENSMUST00000114086.5 ENSMUST00000114086.6 ENSMUST00000114086.7 KLF7_MOUSE NM_033563 Q99JB0 Q99P62 uc007bgn.1 uc007bgn.2 uc007bgn.3 Transcriptional factor (PubMed:11245580). Plays a critical role in neuronal morphogenesis (PubMed:11336497, PubMed:15964824). Represses the corneal epithelium differentiation (By similarity). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells. Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (By similarity). Interacts with FBXO38. Nucleus Widely expressed (PubMed:11336497). Detected in the cornea epithelium (at protein level) (PubMed:28916725). Expression starts at 8.5 dpc in the trigeminal ganglion, the VII-VIII neural crest complex, and the subventricular neuroepithelium of both forebrain and hindbrain regions. At 11.5 dpc, expression is detected in the neural crest-derived sensory nervous system and, at 15.5 dpc, in the brain, spinal cord, retinal neuroepithelium and the inferior XI/X complex (PubMed:11336497, PubMed:11245580). In postnatal and adult animals, expression is confined to the cerebellum and dorsal root ganglia (PubMed:11336497). Expressed in the cornea epithelium at both 18.5 dpc and early postnatal (P5) but not at P50, when the corneal epithelium is fully differentiated (PubMed:28916725). The acidic N-terminal part may favor interaction with the basic domain of transcription factors. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF7, the motif is inactive. Deficient mice die within the first 3 days of life, showing little or no milk in the stomachs, hypopnea, cyanosis, olfactory bulb hypoplasia, axon outgrowth defects in the olfactory and optic nerves, defects of axon growth in the brain and reduced dendritic branching in the hippocampus. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription from RNA polymerase II promoter axonogenesis axon guidance glucose homeostasis regulation of epidermal cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding dendrite morphogenesis negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of adipose tissue development uc007bgn.1 uc007bgn.2 uc007bgn.3 
ENSMUST00000114094.3 Mdh1b ENSMUST00000114094.3 malate dehydrogenase 1B, NAD (soluble) (from RefSeq NM_029696.4) ENSMUST00000114094.1 ENSMUST00000114094.2 MDH1B_MOUSE NM_029696 Q5F204 Q80YT6 Q9D988 uc007bgj.1 uc007bgj.2 uc007bgj.3 Belongs to the LDH/MDH superfamily. MDH type 2 family. Sequence=AAH50786.1; Type=Erroneous initiation; Evidence=; Sequence=BAB24922.1; Type=Erroneous initiation; Evidence=; catalytic activity carbohydrate metabolic process tricarboxylic acid cycle oxaloacetate metabolic process malate metabolic process NADH metabolic process oxidoreductase activity malate dehydrogenase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor L-malate dehydrogenase activity oxidation-reduction process uc007bgj.1 uc007bgj.2 uc007bgj.3 
ENSMUST00000114099.6 Otop1 ENSMUST00000114099.6 otopetrin 1 (from RefSeq NM_172709.3) A0A0R4J1J4 E9QMU2 ENSMUST00000114099.1 ENSMUST00000114099.2 ENSMUST00000114099.3 ENSMUST00000114099.4 ENSMUST00000114099.5 NM_172709 OTOP1_MOUSE Otop1 Q7M735 Q80VM9 Q8BRZ4 Q8BS22 uc008xgm.1 uc008xgm.2 uc008xgm.3 Proton-selective channel that specifically transports protons into cells (PubMed:29371428). Proton channel activity is only weakly- sensitive to voltage (PubMed:29371428). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (PubMed:29371428). In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (PubMed:12651873). Probably acts by maintaining the pH appropriate for formation of otoconia (PubMed:29371428). Regulates purinergic control of intracellular calcium in vestibular supporting cells (PubMed:17606897, PubMed:20554841). May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (PubMed:29371428). Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity- induced metabolic dysfunction (PubMed:24379350). Cell membrane ; Multi-pass membrane protein Note=Detected in the gelatinous membrane overlying the inner ear macular epithelium. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A, Otopetrin-1a, Otop1-a; IsoId=Q80VM9-1; Sequence=Displayed; Name=2; Synonyms=C, Otopetrin-1c, Otop1-c; IsoId=Q80VM9-2; Sequence=VSP_030160; Name=3; Synonyms=B, Otopetrin-1b, Otop1-b; IsoId=Q80VM9-3; Sequence=VSP_030161; Detected in embryonic inner ear macular epithelia (PubMed:12651873). Expressed in thymus, heart, kidney, skin, vestibular system of the inner ear, sour taste cells, brown adipose tissue, heart, uterus, dorsal root ganglion, adrenal gland, lactating mammary gland and stimulated mast cells (PubMed:12651873, PubMed:29371428). Specifically expressed in sour taste cells and not other types of taste cells (PubMed:29371428). Up-regulated in white adipose tissue in response to pro- inflammatory signaling. Mice display defects in the formation of otoconia in the inner ear, but do not suffer from deafness or other inner ear defects (PubMed:12651873). They cannot perceive gravity and have problems with spatial orientation and with keeping their equilibrium (PubMed:12651873). They show typical head-tilting behavior and are unable to swim (PubMed:12651873). Mice develop more severe diet-induced metabolic disorders: they respond to high-fat diet with pronounced insulin resistance and hepatic steatosis, accompanied by augmented adipose tissue inflammation (PubMed:24379350). Belongs to the otopetrin family. Name=Protein Spotlight; Note=Ear of stone - Issue 89 of December 2007; URL="https://web.expasy.org/spotlight/back_issues/089"; plasma membrane integral component of plasma membrane ion transport detection of gravity hydrogen ion channel activity membrane integral component of membrane biomineral tissue development cellular response to insulin stimulus inner ear morphogenesis negative regulation of interferon-gamma-mediated signaling pathway hydrogen ion transmembrane transport uc008xgm.1 uc008xgm.2 uc008xgm.3 
ENSMUST00000114112.4 St3gal5 ENSMUST00000114112.4 ST3 beta-galactoside alpha-2,3-sialyltransferase 5, transcript variant 2 (from RefSeq NM_011375.4) A0A0R4J1J3 A0A0R4J1J3_MOUSE ENSMUST00000114112.1 ENSMUST00000114112.2 ENSMUST00000114112.3 NM_011375 St3gal5 uc009chz.1 uc009chz.2 uc009chz.3 uc009chz.4 Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) = CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+); Xref=Rhea:RHEA:41784, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:73110, ChEBI:CHEBI:78484; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41785; Evidence=; Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) = CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+); Xref=Rhea:RHEA:41776, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78485, ChEBI:CHEBI:78486; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41777; Evidence=; Reaction=a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N- acetyl-beta-neuraminate = a ganglioside GM3 (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:18417, ChEBI:CHEBI:15378, ChEBI:CHEBI:17950, ChEBI:CHEBI:57812, ChEBI:CHEBI:60065, ChEBI:CHEBI:60377; EC=2.4.3.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18418; Evidence=; Reaction=beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl- (1<->1')-ceramide; Xref=Rhea:RHEA:41780, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:82643, ChEBI:CHEBI:143593; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41781; Evidence=; Golgi apparatus membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 29 family. Golgi apparatus protein glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups sialylation uc009chz.1 uc009chz.2 uc009chz.3 uc009chz.4 
ENSMUST00000114116.2 Pwwp4d ENSMUST00000114116.2 PWWP domain containing 4D (from RefSeq NM_001081670.2) A2BG95 A2BG95_MOUSE ENSMUST00000114116.1 NM_001081670 Pwwp4d uc009tpk.1 uc009tpk.2 uc009tpk.3 uc009tpk.4 Belongs to the PWWP3A family. molecular_function cellular_component biological_process uc009tpk.1 uc009tpk.2 uc009tpk.3 uc009tpk.4 
ENSMUST00000114117.2 Ctag2l2 ENSMUST00000114117.2 CTAG2 like 2 (from RefSeq NM_001099306.1) A2BG94 A2BG94_MOUSE Ctag2l2 ENSMUST00000114117.1 Gm6890 NM_001099306 uc009tpj.1 uc009tpj.2 Belongs to the CTAG/PCC1 family. EKC/KEOPS complex molecular_function positive regulation of transcription from RNA polymerase II promoter tRNA threonylcarbamoyladenosine metabolic process uc009tpj.1 uc009tpj.2 
ENSMUST00000114119.2 Pwwp4c ENSMUST00000114119.2 PWWP domain containing 4C (from RefSeq NM_001099302.1) A3KG49 A3KG49_MOUSE ENSMUST00000114119.1 NM_001099302 Pwwp4c uc009tpi.1 uc009tpi.2 Belongs to the PWWP3A family. molecular_function cellular_component biological_process uc009tpi.1 uc009tpi.2 
ENSMUST00000114125.2 Ctag2l1 ENSMUST00000114125.2 CTAG2 like 1 (from RefSeq NM_001099305.1) A3KG45 A3KG45_MOUSE Ctag2l1 ENSMUST00000114125.1 Gm6880 NM_001099305 uc009tpg.1 uc009tpg.2 Belongs to the CTAG/PCC1 family. EKC/KEOPS complex molecular_function positive regulation of transcription from RNA polymerase II promoter tRNA threonylcarbamoyladenosine metabolic process uc009tpg.1 uc009tpg.2 
ENSMUST00000114126.9 Stx18 ENSMUST00000114126.9 syntaxin 18, transcript variant 1 (from RefSeq NM_026959.3) ENSMUST00000114126.1 ENSMUST00000114126.2 ENSMUST00000114126.3 ENSMUST00000114126.4 ENSMUST00000114126.5 ENSMUST00000114126.6 ENSMUST00000114126.7 ENSMUST00000114126.8 NM_026959 Q3TDJ0 Q8VDS8 Q9D8T6 STX18_MOUSE uc008xfy.1 uc008xfy.2 uc008xfy.3 uc008xfy.4 uc008xfy.5 Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L (By similarity). Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Golgi apparatus membrane ; Single-pass type IV membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VDS8-1; Sequence=Displayed; Name=2; IsoId=Q8VDS8-2; Sequence=VSP_017902; Name=3; IsoId=Q8VDS8-3; Sequence=VSP_017903, VSP_017904; Belongs to the syntaxin family. Golgi membrane SNAP receptor activity endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus intracellular protein transport retrograde vesicle-mediated transport, Golgi to ER protein transport membrane integral component of membrane vesicle-mediated transport protein domain specific binding SNARE complex membrane fusion endoplasmic reticulum membrane organization positive regulation of organelle assembly positive regulation of ER to Golgi vesicle-mediated transport regulation of Golgi organization uc008xfy.1 uc008xfy.2 uc008xfy.3 uc008xfy.4 uc008xfy.5 
ENSMUST00000114143.10 Fam3a ENSMUST00000114143.10 FAM3 metabolism regulating signaling molecule A, transcript variant 1 (from RefSeq NM_025473.5) ENSMUST00000114143.1 ENSMUST00000114143.2 ENSMUST00000114143.3 ENSMUST00000114143.4 ENSMUST00000114143.5 ENSMUST00000114143.6 ENSMUST00000114143.7 ENSMUST00000114143.8 ENSMUST00000114143.9 FAM3A_MOUSE NM_025473 Q9D8T0 uc009tox.1 uc009tox.2 uc009tox.3 uc009tox.4 uc009tox.5 Secreted Belongs to the FAM3 family. molecular_function cellular_component extracellular region antifungal humoral response negative regulation of gluconeogenesis regulation of lipid biosynthetic process negative regulation of antifungal innate immune response uc009tox.1 uc009tox.2 uc009tox.3 uc009tox.4 uc009tox.5 
ENSMUST00000114144.9 Islr2 ENSMUST00000114144.9 immunoglobulin superfamily containing leucine-rich repeat 2, transcript variant 8 (from RefSeq NM_001161541.1) C8XPY9 ENSMUST00000114144.1 ENSMUST00000114144.2 ENSMUST00000114144.3 ENSMUST00000114144.4 ENSMUST00000114144.5 ENSMUST00000114144.6 ENSMUST00000114144.7 ENSMUST00000114144.8 ISLR2_MOUSE Kiaa1465 Linx NM_001161541 Q5RKR3 Q6ZPQ3 uc012guk.1 uc012guk.2 uc012guk.3 Required for axon extension during neural development. Homomultimer. Interacts with NTRK1/TrkA. Cell membrane ; Single-pass membrane protein At 11.5 dpc, expressed in spinal nerves, their roots and the ventral spinal cord. At 12.5 dpc, detected in the ventral spinal cord, dorsal root ganglia (DRG), dorsal and ventral roots and sympathetic chain ganglia. At 12.5 dpc, expressed in almost all motor neurons which also express RET and in almost all DRG sensory neurons which also express NTRK1. At 18.5 dpc, expressed only in a subset of NTRK1-expressing neurons but still expressed in nearly all RET- expressing neurons. Sensory and motor neuron axonal projection defects. Sequence=BAC98177.1; Type=Erroneous initiation; Evidence=; protein binding plasma membrane multicellular organism development nervous system development cell surface membrane integral component of membrane positive regulation of axon extension uc012guk.1 uc012guk.2 uc012guk.3 
ENSMUST00000114157.3 Nrp2 ENSMUST00000114157.3 neuropilin 2, transcript variant 1 (from RefSeq NM_001077403.1) B1AT44 ENSMUST00000114157.1 ENSMUST00000114157.2 NM_001077403 NRP2_MOUSE O35373 O35374 O35375 O35376 O35377 O35378 uc007bfl.1 uc007bfl.2 uc007bfl.3 High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. Heterodimer with NRP1. Binds PLXNB1 (By similarity). Membrane ; Single- pass type I membrane protein Event=Alternative splicing; Named isoforms=6; Name=A22; IsoId=O35375-1; Sequence=Displayed; Name=A0; IsoId=O35375-2; Sequence=VSP_004344; Name=A5; IsoId=O35375-3; Sequence=VSP_004345; Name=A17; IsoId=O35375-4; Sequence=VSP_004343; Name=B0; IsoId=O35375-5; Sequence=VSP_004346; Name=B5; IsoId=O35375-6; Sequence=VSP_004347; Expressed in developing CNS, PNS and in some nonneural tissues including limb buds, developing bones, muscles, intestinal epithelium, kidney, lung and submandibular gland. The expression pattern is very dynamic and is developmentally regulated. The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding. Belongs to the neuropilin family. angiogenesis neural crest cell migration neuron migration outflow tract septum morphogenesis vascular endothelial growth factor-activated receptor activity protein binding plasma membrane multicellular organism development nervous system development axon guidance heart development heparin binding membrane integral component of membrane semaphorin receptor activity facial nerve structural organization vestibulocochlear nerve structural organization nerve development gonadotrophin-releasing hormone neuronal migration to the hypothalamus cell differentiation axon ventral trunk neural crest cell migration vascular endothelial growth factor signaling pathway identical protein binding metal ion binding axon extension involved in axon guidance negative chemotaxis sympathetic ganglion development trigeminal ganglion development sensory neuron axon guidance sympathetic neuron projection extension sympathetic neuron projection guidance glutamatergic synapse integral component of postsynaptic membrane neural crest cell migration involved in autonomic nervous system development semaphorin-plexin signaling pathway involved in neuron projection guidance facioacoustic ganglion development dorsal root ganglion morphogenesis cellular response to leukemia inhibitory factor uc007bfl.1 uc007bfl.2 uc007bfl.3 
ENSMUST00000114160.2 Fam50a ENSMUST00000114160.2 family with sequence similarity 50, member A (from RefSeq NM_138607.3) D0HXS9928E ENSMUST00000114160.1 FA50A_MOUSE NM_138607 Q9D866 Q9WV03 Xap5 uc009ton.1 uc009ton.2 uc009ton.3 Probably involved in the regulation of pre-mRNA splicing. Interacts with EFTUD2, a component of the spliceosome U5 complex. Interacts with DDX41, a component of the spliceosome C complex. Nucleus Widely expressed in embryonic and adult tissues. Belongs to the FAM50 family. nucleus nucleoplasm uc009ton.1 uc009ton.2 uc009ton.3 
ENSMUST00000114167.9 Camsap1 ENSMUST00000114167.9 calmodulin regulated spectrin-associated protein 1, transcript variant 11 (from RefSeq NR_176450.1) A0A0A0MQE5 A0A0A0MQE5_MOUSE Camsap1 ENSMUST00000114167.1 ENSMUST00000114167.2 ENSMUST00000114167.3 ENSMUST00000114167.4 ENSMUST00000114167.5 ENSMUST00000114167.6 ENSMUST00000114167.7 ENSMUST00000114167.8 NR_176450 uc033hlz.1 uc033hlz.2 Cytoplasm, cytoskeleton The CKK domain binds microtubules. Belongs to the CAMSAP1 family. microtubule cytoskeleton organization calmodulin binding microtubule cytoskeleton organization microtubule binding regulation of cell morphogenesis spectrin binding regulation of microtubule polymerization neuron projection development microtubule minus-end microtubule minus-end binding uc033hlz.1 uc033hlz.2 
ENSMUST00000114172.6 Kcnt1 ENSMUST00000114172.6 potassium channel, subfamily T, member 1, transcript variant 3 (from RefSeq NM_001302351.2) B2RUK3 ENSMUST00000114172.1 ENSMUST00000114172.2 ENSMUST00000114172.3 ENSMUST00000114172.4 ENSMUST00000114172.5 KCNT1_MOUSE Kiaa1422 NM_001302351 Q6ZPR4 Q8C3E7 uc012bsi.1 uc012bsi.2 uc012bsi.3 uc012bsi.4 This gene encodes a member of the Slo potassium channel family that has shown to be activated by both sodium and chloride ions. This channel represents the largest potassium channel subunit yet identified. This channel may be important in development and pain signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). Interacts (via C-terminus) with FMR1; this interaction alters gating properties of KCNT1 (By similarity). Interacts with CRBN via its cytoplasmic C-terminus (By similarity). Cell membrane ; Multi-pass membrane protein Phosphorylated by protein kinase C. Phosphorylation of the C- terminal domain increases channel activity (By similarity). Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily. intracellular sodium activated potassium channel activity potassium channel activity plasma membrane ion transport potassium ion transport outward rectifier potassium channel activity membrane integral component of membrane potassium ion transmembrane transport uc012bsi.1 uc012bsi.2 uc012bsi.3 uc012bsi.4 
ENSMUST00000114174.3 Cyyr1 ENSMUST00000114174.3 cysteine and tyrosine-rich protein 1 (from RefSeq NM_144853.4) CYYR1_MOUSE ENSMUST00000114174.1 ENSMUST00000114174.2 NM_144853 Q499D9 Q8VIH7 uc007ztu.1 uc007ztu.2 uc007ztu.3 uc007ztu.4 uc007ztu.5 Membrane ; Single-pass type I membrane protein Belongs to the CYYR1 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007ztu.1 uc007ztu.2 uc007ztu.3 uc007ztu.4 uc007ztu.5 
ENSMUST00000114180.11 Tafazzin ENSMUST00000114180.11 tafazzin, phospholipid-lysophospholipid transacylase, transcript variant 1 (from RefSeq NM_001173547.2) ENSMUST00000114180.1 ENSMUST00000114180.10 ENSMUST00000114180.2 ENSMUST00000114180.3 ENSMUST00000114180.4 ENSMUST00000114180.5 ENSMUST00000114180.6 ENSMUST00000114180.7 ENSMUST00000114180.8 ENSMUST00000114180.9 I7HJS2 I7HJS2_MOUSE NM_001173547 RP23-436K3.6-015 TAZ Tafazzin Taz uc009toh.1 uc009toh.2 uc009toh.3 uc009toh.4 uc009toh.5 This gene encodes a mitochondrial phospholipid-lysophospholipid transacylase necessary for normal composition and content of cardiolipin. In humans, mutations of this gene result in Barth syndrome, most often characterized by cardioskeletal myopathy, neutropenia and abnormal mitochondria. This gene is distinct from the gene encoding transcriptional coactivator with PDZ binding motif. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]. Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. Reaction=1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3- phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1- acyl-sn-glycero-3-phosphocholine + a cardiolipin; Xref=Rhea:RHEA:33731, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:62237, ChEBI:CHEBI:64743; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33732; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:33733; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1- hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn- glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn- glycero-3-phosphocholine; Xref=Rhea:RHEA:43816, ChEBI:CHEBI:28610, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001, ChEBI:CHEBI:74669; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43817; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:43818; Evidence=; Reaction=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl- sn-glycero-3-phosphate = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate; Xref=Rhea:RHEA:67748, ChEBI:CHEBI:57970, ChEBI:CHEBI:58608, ChEBI:CHEBI:64716, ChEBI:CHEBI:64840; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67749; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:67750; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2- (9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1- (9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol); Xref=Rhea:RHEA:67752, ChEBI:CHEBI:72840, ChEBI:CHEBI:74544, ChEBI:CHEBI:74563, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67753; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:67754; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2- dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:68988, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999, ChEBI:CHEBI:73002, ChEBI:CHEBI:76084; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68989; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68990; Evidence=; Associates with multiple protein complexes. Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side Mitochondrion outer membrane ; Peripheral membrane protein ; Intermembrane side Belongs to the taffazin family. mitochondrion phospholipid metabolic process muscle contraction inner mitochondrial membrane organization heart development skeletal muscle tissue development membrane integral component of membrane transferase activity, transferring acyl groups hemopoiesis cardiolipin biosynthetic process mitochondrial respiratory chain complex I assembly cardiolipin acyl-chain remodeling cristae formation mitochondrial ATP synthesis coupled electron transport phosphatidylglycerol metabolic process 1-acylglycerophosphocholine O-acyltransferase activity cardiac muscle tissue development cardiac muscle contraction positive regulation of cardiolipin metabolic process positive regulation of ATP biosynthetic process uc009toh.1 uc009toh.2 uc009toh.3 uc009toh.4 uc009toh.5 
ENSMUST00000114185.4 Gm1070 ENSMUST00000114185.4 Gm1070 (from geneSymbol) BC147402 ENSMUST00000114185.1 ENSMUST00000114185.2 ENSMUST00000114185.3 uc012enf.1 uc012enf.2 uc012enf.3 uc012enf.1 uc012enf.2 uc012enf.3 
ENSMUST00000114192.2 Obp2b ENSMUST00000114192.2 odorant binding protein 2B (from RefSeq NM_001378280.1) A2BHR0 A2BHR0_MOUSE ENSMUST00000114192.1 Lcn14 NM_001378280 Obp2b uc008ith.1 uc008ith.2 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc008ith.1 uc008ith.2 
ENSMUST00000114195.8 Jam2 ENSMUST00000114195.8 junction adhesion molecule 2 (from RefSeq NM_023844.5) A6X955 ENSMUST00000114195.1 ENSMUST00000114195.2 ENSMUST00000114195.3 ENSMUST00000114195.4 ENSMUST00000114195.5 ENSMUST00000114195.6 ENSMUST00000114195.7 JAM2_MOUSE Jam2 NM_023844 Q8C5K9 Q8CE95 Q9JI59 Vejam uc007ztg.1 uc007ztg.2 uc007ztg.3 uc007ztg.4 uc007ztg.5 Junctional adhesion protein that mediates heterotypic cell- cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:16093349, PubMed:21868569, PubMed:24357068). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:21868569, PubMed:24357068). At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:21868569, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:16297198, PubMed:19740376). Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:19740376). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (Probable). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (PubMed:27499083). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (PubMed:25911611). Cell membrane ingle-pass type I membrane protein Cell junction Cell junction, tight junction te=Localized at tight junctions of both epithelial, endothelial cells and Sertoli cells (PubMed:11036763). Specifically localized within the somatodendritic compartment of neurons and excluded from the axon (PubMed:27499083). Expressed by bone marrow stromal cells (at protein level) (PubMed:21868569). Expressed in skin (at protein level) (PubMed:16297198). Expressed in testis by Sertoli cells (at protein level) (PubMed:15372036, PubMed:25817991). Expressed by dorsal root ganglion and spinal cord neurons (PubMed:27499083). The Ig-like V-type domain is necessary and sufficient to mediate interaction with JAM3 and integrin alpha-4/beta-1. The expression in Sertoli cells is regulated by TGFB3 through ubiquitin-mediated proteasomal degradation. Mice lacking Jam2 do not display overt morphological, vascular or immunologic phenotype (PubMed:21868569). However, aberrant myelination of dorsal horn interneuron cell bodies is observed (PubMed:27499083, PubMed:21868569). They develop age-dependent significant walking and gait abnormalities compared to controls. Neuropathologic brain analysis show age-dependent progressive prominent vacuolization in the midbrain, thalamus, and cerebral and cerebellar cortices. These changes are associated with reactive astrogliosis, microglial activation, and a reduced neuronal density. Similar findings are observed in spinal cord sections. There is no evidence of mineralization or calcification in the brain or spinal cord of mutant mice (PubMed:32142645). Belongs to the immunoglobulin superfamily. plasma membrane bicellular tight junction negative regulation of cell adhesion cell surface membrane integral component of membrane cell junction cell-cell contact zone protein heterodimerization activity leukocyte tethering or rolling lymphocyte aggregation positive regulation of lymphocyte migration uc007ztg.1 uc007ztg.2 uc007ztg.3 uc007ztg.4 uc007ztg.5 
ENSMUST00000114199.8 Lcn6 ENSMUST00000114199.8 lipocalin 6, transcript variant 2 (from RefSeq NM_177840.4) A2AJB9 A2AJB9_MOUSE ENSMUST00000114199.1 ENSMUST00000114199.2 ENSMUST00000114199.3 ENSMUST00000114199.4 ENSMUST00000114199.5 ENSMUST00000114199.6 ENSMUST00000114199.7 Lcn6 NM_177840 uc012bse.1 uc012bse.2 uc012bse.3 Secreted Belongs to the calycin superfamily. Lipocalin family. molecular_function cellular_component biological_process small molecule binding uc012bse.1 uc012bse.2 uc012bse.3 
ENSMUST00000114200.10 Fam219b ENSMUST00000114200.10 family with sequence similarity 219, member B, transcript variant 1 (from RefSeq NM_001166364.1) ENSMUST00000114200.1 ENSMUST00000114200.2 ENSMUST00000114200.3 ENSMUST00000114200.4 ENSMUST00000114200.5 ENSMUST00000114200.6 ENSMUST00000114200.7 ENSMUST00000114200.8 ENSMUST00000114200.9 F219B_MOUSE NM_001166364 Q14DQ1 Q8BSZ6 uc009pvb.1 uc009pvb.2 uc009pvb.3 uc009pvb.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14DQ1-1; Sequence=Displayed; Name=2; IsoId=Q14DQ1-2; Sequence=VSP_036130, VSP_036131; Belongs to the FAM219 family. molecular_function cellular_component biological_process uc009pvb.1 uc009pvb.2 uc009pvb.3 uc009pvb.4 
ENSMUST00000114212.4 Igkv13-85 ENSMUST00000114212.4 Igkv13-85 (from geneSymbol) A0A075B666 A0A075B666_MOUSE ENSMUST00000114212.1 ENSMUST00000114212.2 ENSMUST00000114212.3 Igkv13-85 JF330319 uc291fjp.1 uc291fjp.2 immunoglobulin production extracellular space immune response uc291fjp.1 uc291fjp.2 
ENSMUST00000114232.4 H2-DMb1 ENSMUST00000114232.4 histocompatibility 2, class II, locus Mb1 (from RefSeq NM_010387.3) ENSMUST00000114232.1 ENSMUST00000114232.2 ENSMUST00000114232.3 H2-DMb1 H2-DMb2 H2-M beta1 NM_010387 Q31094 Q31094_MOUSE uc008cbr.1 uc008cbr.2 uc008cbr.3 Membrane ; Single- pass type I membrane protein Belongs to the MHC class II family. adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune response membrane integral component of membrane antigen processing and presentation MHC class II protein complex uc008cbr.1 uc008cbr.2 uc008cbr.3 
ENSMUST00000114236.2 Tnip3 ENSMUST00000114236.2 TNFAIP3 interacting protein 3 (from RefSeq NM_001001495.2) 9030611K07Rik ENSMUST00000114236.1 NM_001001495 Q3SXA6 Q3SXA6_MOUSE Tnip3 uc009ceh.1 uc009ceh.2 MyD88-independent toll-like receptor signaling pathway polyubiquitin binding toll-like receptor 4 signaling pathway negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription from RNA polymerase II promoter cellular response to lipopolysaccharide uc009ceh.1 uc009ceh.2 
ENSMUST00000114239.9 Samsn1 ENSMUST00000114239.9 SAM domain, SH3 domain and nuclear localization signals, 1 (from RefSeq NM_023380.2) ENSMUST00000114239.1 ENSMUST00000114239.2 ENSMUST00000114239.3 ENSMUST00000114239.4 ENSMUST00000114239.5 ENSMUST00000114239.6 ENSMUST00000114239.7 ENSMUST00000114239.8 NM_023380 P57725 Q2LE09 Q5RKU0 Q6P210 Q8C6S2 SAMN1_MOUSE uc007zrs.1 uc007zrs.2 uc007zrs.3 Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation. Interacts with FASLG (By similarity). Interacts with phosphotyrosine containing proteins. Interacts (via SH3 domain) with CTTN. Interacts (phosphorylated at Ser-23) with YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ and SFN. Interacts directly with SAP30 and HDAC1. Identified in a complex with SAP30 and HDAC1. Nucleus. Cytoplasm. Cell projection, ruffle. Note=Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles. Detected in spleen and lymph node (at protein level). Up-regulated in peripheral blood B-cells by IL4 and bacterial lipopolysaccharide (LPS). No visible phenotype. Mice have normal bone marrow B-cell development and normal splenic T- and B-cell populations, but show an enhanced immune response upon immunization. Mice have constitutively activated Lyn, due to constitutive Lyn tyrosine phosphorylation. ruffle phosphotyrosine binding negative regulation of adaptive immune response nucleus cytoplasm cytosol plasma membrane cell projection negative regulation of peptidyl-tyrosine phosphorylation negative regulation of B cell activation uc007zrs.1 uc007zrs.2 uc007zrs.3 
ENSMUST00000114243.8 Gm973 ENSMUST00000114243.8 predicted gene 973, transcript variant 5 (from RefSeq NM_001404392.1) E9Q295 E9Q295_MOUSE ENSMUST00000114243.1 ENSMUST00000114243.2 ENSMUST00000114243.3 ENSMUST00000114243.4 ENSMUST00000114243.5 ENSMUST00000114243.6 ENSMUST00000114243.7 Gm973 NM_001404392 uc007bdv.1 uc007bdv.2 molecular_function cellular_component biological_process uc007bdv.1 uc007bdv.2 
ENSMUST00000114246.4 Fzd7 ENSMUST00000114246.4 frizzled class receptor 7 (from RefSeq NM_008057.3) ENSMUST00000114246.1 ENSMUST00000114246.2 ENSMUST00000114246.3 FZD7_MOUSE G3X953 NM_008057 Q61090 uc011wlq.1 uc011wlq.2 uc011wlq.3 Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes. Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts with MAGI3 (PubMed:15195140). Interacts with DVL1 (PubMed:15353129). Interacts with CCDC88C/DAPLE; the interaction displaces DVL1 from FZD7, leading to inhibition of canonical Wnt signaling and triggering of non-canonical Wnt responses (By similarity). Interacts with MYOC (By similarity). Binds to SDCBP; this interaction is increased by inositol trisphosphate (IP3) (By similarity). Interacts with glypican GPC3 (By similarity). Q61090; Q62108: Dlg4; NbExp=4; IntAct=EBI-8473104, EBI-300895; Cell membrane ulti-pass membrane protein Endosome membrane ; Multi-pass membrane protein Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions. Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. The FZ domain is involved in binding with Wnt ligands. Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. Belongs to the G-protein coupled receptor Fz/Smo family. transmembrane signaling receptor activity G-protein coupled receptor activity frizzled binding protein binding phosphatidylinositol-4,5-bisphosphate binding endosome plasma membrane regulation of transcription, DNA-templated signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway multicellular organism development endosome membrane negative regulation of cell-substrate adhesion skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration membrane integral component of membrane Wnt signaling pathway Wnt-protein binding stem cell population maintenance PDZ domain binding T cell differentiation in thymus substrate adhesion-dependent cell spreading non-canonical Wnt signaling pathway non-canonical Wnt signaling pathway via JNK cascade positive regulation of phosphorylation negative regulation of ectodermal cell fate specification Wnt-activated receptor activity positive regulation of transcription, DNA-templated somatic stem cell division recycling endosome membrane positive regulation of epithelial cell proliferation involved in wound healing canonical Wnt signaling pathway mesenchymal to epithelial transition regulation of canonical Wnt signaling pathway negative regulation of cardiac muscle cell differentiation uc011wlq.1 uc011wlq.2 uc011wlq.3 
ENSMUST00000114248.3 Cdk15 ENSMUST00000114248.3 cyclin dependent kinase 15, transcript variant 2 (from RefSeq NM_001356389.1) Als2cr7 B2RVR3 B7ZWG3 CDK15_MOUSE ENSMUST00000114248.1 ENSMUST00000114248.2 NM_001356389 Pftk2 Q3V3A1 uc007bdr.1 uc007bdr.2 uc007bdr.3 Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q3V3A1-1; Sequence=Displayed; Name=2 ; IsoId=Q3V3A1-2; Sequence=VSP_052350, VSP_052351; Name=3; IsoId=Q3V3A1-3; Sequence=VSP_038766; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus cytoplasm cytosol protein phosphorylation kinase activity phosphorylation transferase activity cyclin binding metal ion binding regulation of cell cycle uc007bdr.1 uc007bdr.2 uc007bdr.3 
ENSMUST00000114251.8 Ptgds ENSMUST00000114251.8 prostaglandin D2 synthase (brain), transcript variant 4 (from RefSeq NM_001420746.1) ENSMUST00000114251.1 ENSMUST00000114251.2 ENSMUST00000114251.3 ENSMUST00000114251.4 ENSMUST00000114251.5 ENSMUST00000114251.6 ENSMUST00000114251.7 NM_001420746 O09114 O09157 O35091 PTGDS_MOUSE Q3V2G5 Q62169 uc289tyl.1 uc289tyl.2 Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed:10781097, PubMed:11751991, PubMed:12077186, PubMed:17715133, PubMed:19546224, PubMed:19833210, PubMed:8922532, PubMed:9892701). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557). Reaction=prostaglandin H2 = prostaglandin D2; Xref=Rhea:RHEA:10600, ChEBI:CHEBI:57405, ChEBI:CHEBI:57406; EC=5.3.99.2; Evidence=; Kinetic parameters: KM=0.8 uM for prostaglandin H2 ; Vmax=5.9 umol/min/mg enzyme ; Monomer. Rough endoplasmic reticulum Nucleus membrane Golgi apparatus Cytoplasm, perinuclear region Secreted Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O09114-1; Sequence=Displayed; Name=2; IsoId=O09114-2; Sequence=VSP_041029; Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. In the male reproductive system, it is expressed in the testis, efferent ducts and epididymis, and is secreted into the seminal fluid. In the eye, it is expressed in the pigmented epithelium of the retina and the nonpigmented epithelium of the ciliary body, and secreted into the aqueous humor. Low levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including the ear, heart and lung. Initially detected at 14.5 dpc in the mesenchymal cells of the brain. Later in development, observed in the choroid plexus and within single cells in the brain. By IL-1 beta and thyroid hormone. Probably induced by dexamethasone, dihydrotestosterone, progesterone, retinoic acid and retinal. Repressed by the Notch-Hes signaling pathway. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Mutant mice show decreased susceptibility to passive cutaneous anaphylaxis associated with decreased mast cell degranulation. Belongs to the calycin superfamily. Lipocalin family. Sequence=BAA21769.1; Type=Frameshift; Evidence=; prostaglandin biosynthetic process prostaglandin-D synthase activity retinoid binding fatty acid binding extracellular region extracellular space nucleus cytoplasm endoplasmic reticulum rough endoplasmic reticulum Golgi apparatus lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process membrane isomerase activity nuclear membrane small molecule binding regulation of circadian sleep/wake cycle, sleep perinuclear region of cytoplasm response to glucocorticoid negative regulation of male germ cell proliferation uc289tyl.1 uc289tyl.2 
ENSMUST00000114253.2 Rbm11 ENSMUST00000114253.2 RNA binding motif protein 11, transcript variant 1 (from RefSeq NM_198302.3) D3Z0X9 ENSMUST00000114253.1 NM_198302 Q80YT9 Q8BYK1 RBM11_MOUSE uc007zro.1 uc007zro.2 Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 (By similarity). Homodimer. Nucleus, nucleoplasm Nucleus speckle Note=Enriched in SRSF2-containing splicing speckles; shuttles between nucleoplasm and speckles. Selectively expressed in brain, cerebellum and testis, and to a lower extent in kidney. Peaks perinatally in brain and cerebellum, and at puberty in testis, in concomitance with differentiation events occurring in neurons and germ cells. Sequence=EDK98269.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding single-stranded RNA binding nucleus nucleoplasm mRNA processing multicellular organism development poly(U) RNA binding RNA splicing nuclear speck cell differentiation cellular response to oxidative stress protein homodimerization activity uc007zro.1 uc007zro.2 
ENSMUST00000114261.9 Paxx ENSMUST00000114261.9 non-homologous end joining factor (from RefSeq NM_153557.2) ENSMUST00000114261.1 ENSMUST00000114261.2 ENSMUST00000114261.3 ENSMUST00000114261.4 ENSMUST00000114261.5 ENSMUST00000114261.6 ENSMUST00000114261.7 ENSMUST00000114261.8 NM_153557 PAXX_MOUSE Paxx Q8C6V7 Q8K0Y7 uc008ise.1 uc008ise.2 uc008ise.3 Non-essential DNA repair protein involved in DNA non- homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination (PubMed:27601299, PubMed:27798842, PubMed:27601633, PubMed:27830975, PubMed:28051062, PubMed:29077092). May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery (PubMed:28051062). Involved in NHEJ by promoting the ligation of blunt- ended DNA ends (By similarity). Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (By similarity). Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair (PubMed:27601299, PubMed:27798842, PubMed:27830975, PubMed:28051062). Homodimer (By similarity). Interacts with the DNA-bound XRCC5/Ku80 and XRCC6/Ku70 heterodimer (Ku complex); the interaction is direct (By similarity). Associated component of the non-homologous end joining (NHEJ) complex, composed of the core proteins PRKDC, LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF (By similarity). Interacts with POLL (DNA polymerase lambda); promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL (By similarity). Nucleus Chromosome Note=Predominantly localizes to the nucleus. Accumulates at sites of DNA damage generated by laser microirradiation. The N-terminus (residues 1-115) forms a head domain that is structurally related to those of XRCC4, XLF/NHEJ1, and SASS6. Phosphorylation may inhibit interaction with the DNA-bound XRCC5/Ku80 and XRCC6/Ku70 heterodimer (Ku complex). No visible phenotype in normal conditions (PubMed:27798842, PubMed:28051062, PubMed:29511619, PubMed:29511621). Mice are viable, grow normally, are fertile and have normal lymphocyte development (PubMed:27798842, PubMed:29511619, PubMed:29511621). They however show mild radiosensitivity (PubMed:29511619, PubMed:29511621). Mice lacking both Paxx and Nhej1/Xlf show embryonic lethality caused by severe defects in classical non-homologous end joining (NHEJ) (PubMed:27601299, PubMed:27798842, PubMed:27601633, PubMed:27830975, PubMed:28051062, PubMed:29077092). Belongs to the XRCC4-XLF family. PAXX subfamily. nucleus DNA repair double-strand break repair via nonhomologous end joining cellular response to DNA damage stimulus site of double-strand break identical protein binding protein homodimerization activity Ku70:Ku80 complex DNA ligation involved in DNA repair binding, bridging nonhomologous end joining complex uc008ise.1 uc008ise.2 uc008ise.3 
ENSMUST00000114265.9 Clic3 ENSMUST00000114265.9 chloride intracellular channel 3 (from RefSeq NM_027085.3) CLIC3_MOUSE ENSMUST00000114265.1 ENSMUST00000114265.2 ENSMUST00000114265.3 ENSMUST00000114265.4 ENSMUST00000114265.5 ENSMUST00000114265.6 ENSMUST00000114265.7 ENSMUST00000114265.8 NM_027085 Q9D7P7 uc008isd.1 uc008isd.2 uc008isd.3 Can insert into membranes and form chloride ion channels. May participate in cellular growth control (By similarity). Associated with the C-terminal of MAPK15. Nucleus Membrane ; Single-pass membrane protein Cytoplasm Note=Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as a chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity). Belongs to the chloride channel CLIC family. voltage-gated ion channel activity chloride channel activity nucleus cytoplasm ion transport chloride transport membrane integral component of membrane nuclear body ion transmembrane transport chloride channel complex regulation of ion transmembrane transport chloride transmembrane transport uc008isd.1 uc008isd.2 uc008isd.3 
ENSMUST00000114270.8 Dok7 ENSMUST00000114270.8 docking protein 7, transcript variant 3 (from RefSeq NM_001348275.1) DOK7_MOUSE ENSMUST00000114270.1 ENSMUST00000114270.2 ENSMUST00000114270.3 ENSMUST00000114270.4 ENSMUST00000114270.5 ENSMUST00000114270.6 ENSMUST00000114270.7 NM_001348275 Q18PE0 Q3TCZ6 Q5FW70 Q8C8U7 uc008xdk.1 uc008xdk.2 uc008xdk.3 Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. Homodimer. Forms a heterotetramer composed of 2 DOK7 and 2 MUSK molecules which facilitates MUSK trans-autophosphorylation on tyrosine residue and activation. Interacts (via IRS-type PTB domain) with MUSK (via cytoplasmic part); requires MUSK phosphorylation. Q18PE0; Q61006: Musk; NbExp=3; IntAct=EBI-3989091, EBI-3989087; Cell membrane ; Peripheral membrane protein Synapse Note=Accumulates at neuromuscular junctions. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q18PE0-1; Sequence=Displayed; Name=2; IsoId=Q18PE0-2; Sequence=VSP_020636; Name=3; IsoId=Q18PE0-3; Sequence=VSP_020637; Expressed in the central region encompassing the endplate area of the diaphragm muscles at day 14.5 of embryonic development (14.5 dpc), when AChRs cluster in a nerve- and agrin- independent manner. The PH domain mediated binding to phospholipids with phosphoinositol headgroups. Affinity is highest for phosphatidyl 3,4,5- trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. Mice are immobile at birth and die shortly thereafter. They do not form neither acetylcholine receptor clusters nor neuromuscular synapses. Sequence=AAH89590.1; Type=Erroneous initiation; Evidence=; Sequence=BAC31923.1; Type=Erroneous initiation; Evidence=; positive regulation of protein phosphorylation protein binding nucleus nucleoplasm mitochondrion plasma membrane neuromuscular junction development lipid binding membrane protein kinase binding cell junction neuromuscular junction phosphatidylinositol binding receptor clustering synapse positive regulation of protein tyrosine kinase activity uc008xdk.1 uc008xdk.2 uc008xdk.3 
ENSMUST00000114276.3 Rcn2 ENSMUST00000114276.3 reticulocalbin 2, transcript variant 1 (from RefSeq NM_011992.2) A2RT07 ENSMUST00000114276.1 ENSMUST00000114276.2 NM_011992 O70341 Q8BP92 RCN2_MOUSE uc009pss.1 uc009pss.2 uc009pss.3 Not known. Binds calcium (By similarity). Q8BP92; Q7TNL3-1: Stk40; NbExp=3; IntAct=EBI-642694, EBI-15828080; Endoplasmic reticulum lumen Belongs to the CREC family. calcium ion binding protein binding nucleolus endoplasmic reticulum endoplasmic reticulum lumen metal ion binding uc009pss.1 uc009pss.2 uc009pss.3 
ENSMUST00000114278.9 Fut7 ENSMUST00000114278.9 fucosyltransferase 7, transcript variant 7 (from RefSeq NM_001289456.1) ENSMUST00000114278.1 ENSMUST00000114278.2 ENSMUST00000114278.3 ENSMUST00000114278.4 ENSMUST00000114278.5 ENSMUST00000114278.6 ENSMUST00000114278.7 ENSMUST00000114278.8 Fut7 NM_001289456 Q3SWS0 Q3SWS0_MOUSE uc008isb.1 uc008isb.2 uc008isb.3 uc008isb.4 uc008isb.5 Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 10 family. Golgi apparatus protein glycosylation fucosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups Golgi cisterna membrane fucosylation uc008isb.1 uc008isb.2 uc008isb.3 uc008isb.4 uc008isb.5 
ENSMUST00000114293.9 Sapcd2 ENSMUST00000114293.9 suppressor APC domain containing 2, transcript variant 2 (from RefSeq NM_001290407.1) A2AJ17 ENSMUST00000114293.1 ENSMUST00000114293.2 ENSMUST00000114293.3 ENSMUST00000114293.4 ENSMUST00000114293.5 ENSMUST00000114293.6 ENSMUST00000114293.7 ENSMUST00000114293.8 NM_001290407 Q3TL89 Q3TP90 Q3TQ24 Q6NS42 Q9D818 SAPC2_MOUSE Sapcd2 uc008irv.1 uc008irv.2 uc008irv.3 uc008irv.4 Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (PubMed:26766442). Negatively regulates the mitotic apical cortex localization of GPSM2 (By similarity). Involved also in positive regulation of cell proliferation and tumor cell growth (By similarity). Interacts with a spindle orientation complex at least composed of GNAI1, GPSM2 and NUMA1. Interacts with GPSM2 (via TPR motifs); this interaction is required to prevent GPSM2 anchoring at the mitotic apical cortex and is inhibited in presence of NUMA1 in a dose dependent manner. Interacts with PARD3. Cytoplasm Nucleus Cytoplasm, cell cortex Apical cell membrane Cell junction, tight junction Note=Localized at the apical membrane during the M phase (PubMed:26766442). In horizontally retinal progenitor dividing cells, localized at the pole cortical region from prophase to telophase cells (PubMed:26766442). In vertically retinal progenitor dividing cells, not detected at the pole cortical region at any stage of mitosis (PubMed:26766442). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D818-1; Sequence=Displayed; Name=2; IsoId=Q9D818-2; Sequence=VSP_025112; Name=3; IsoId=Q9D818-3; Sequence=VSP_025113; Expressed in the retina (PubMed:26766442). Expressed in retinal progenitor cells and newly differentiated neurons but not in mature retinal cells (at protein level) (PubMed:26766442). Expressed in the embryonic retina from 14 to 17 dpc (at protein level) (PubMed:26766442). Expressed throughout neuroectoderm at 7.5 dpc (PubMed:15567712). The expression increases in rostral brain and caudal neuropore regions and decreases in hindbrain and spinal cord regions (PubMed:15567712). At 12.5 dpc the expression is found in undifferentiated neuroepithelium in ventricular zone, dorsal root ganglia and several non-neural tissues (PubMed:15567712). Sequence=AAH70477.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; establishment of mitotic spindle orientation molecular_function nucleus nucleolus cytoplasm cytosol plasma membrane bicellular tight junction cell cortex cell cycle positive regulation of cell proliferation membrane apical plasma membrane cell junction apical junction complex apical cortex cell division regulation of establishment of planar polarity symmetric cell division negative regulation of protein localization to cell cortex uc008irv.1 uc008irv.2 uc008irv.3 uc008irv.4 
ENSMUST00000114297.5 Vopp1 ENSMUST00000114297.5 vesicular, overexpressed in cancer, prosurvival protein 1, transcript variant 1 (from RefSeq NM_146168.1) ENSMUST00000114297.1 ENSMUST00000114297.2 ENSMUST00000114297.3 ENSMUST00000114297.4 Ecop NM_146168 Q3TZ79 Q8C0B7 Q8R1C3 VOPP1_MOUSE uc009cco.1 uc009cco.2 uc009cco.3 Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. May sequester WWOX in lysosomal vesicles and thereby regulate WWOX role as tumor suppressor. Interacts with WWOX (via WW domain). Cytoplasmic vesicle membrane ; Single-pass type I membrane protein Late endosome membrane ; Single-pass membrane protein Lysosome membrane ; Single-pass membrane protein Note=When overexpressed, localizes in the nucleus and perinuclear regions. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R1C3-1; Sequence=Displayed; Name=2; IsoId=Q8R1C3-2; Sequence=VSP_032478, VSP_032479; Belongs to the VOPP1/ECOP family. endosome membrane integral component of membrane cytoplasmic vesicle membrane integral component of organelle membrane cytoplasmic vesicle uc009cco.1 uc009cco.2 uc009cco.3 
ENSMUST00000114299.8 Flna ENSMUST00000114299.8 Belongs to the filamin family. (from UniProt B7FAU9) B7FAU9 B7FAU9_MOUSE BC038478 ENSMUST00000114299.1 ENSMUST00000114299.2 ENSMUST00000114299.3 ENSMUST00000114299.4 ENSMUST00000114299.5 ENSMUST00000114299.6 ENSMUST00000114299.7 Flna RP23-436K3.1-002 uc009tny.1 uc009tny.2 uc009tny.3 Belongs to the filamin family. G-protein coupled receptor binding actin binding nucleus nucleolus cytoplasm cytosol actin filament plasma membrane cell-cell junction cell cortex adenylate cyclase-inhibiting dopamine receptor signaling pathway transcription factor binding potassium channel regulator activity actin cytoskeleton negative regulation of transcription from RNA polymerase I promoter Rho GTPase binding Ral GTPase binding kinase binding formation of radial glial scaffolds cerebral cortex development regulation of cell migration cortical cytoskeleton small GTPase binding Myb complex actin cytoskeleton reorganization mu-type opioid receptor binding positive regulation of actin filament bundle assembly protein localization to cell surface Fc-gamma receptor I complex binding negative regulation of protein catabolic process positive regulation of protein import into nucleus mRNA transcription from RNA polymerase II promoter protein homodimerization activity neuronal cell body negative regulation of apoptotic process receptor clustering dendritic shaft negative regulation of sequence-specific DNA binding transcription factor activity wound healing, spreading of cells ion channel binding macromolecular complex binding establishment of protein localization SMAD binding Rac GTPase binding perinuclear region of cytoplasm protein stabilization actin filament binding GTPase binding cytoplasmic sequestering of protein actin crosslink formation cilium assembly semaphorin-plexin signaling pathway protein localization to plasma membrane mitotic spindle assembly establishment of Sertoli cell barrier apical dendrite postsynapse glutamatergic synapse positive regulation of substrate adhesion-dependent cell spreading positive regulation of potassium ion transmembrane transport protein localization to bicellular tight junction positive regulation of neural precursor cell proliferation positive regulation of integrin-mediated signaling pathway positive regulation of neuron migration uc009tny.1 uc009tny.2 uc009tny.3 
ENSMUST00000114312.2 Grin1 ENSMUST00000114312.2 glutamate receptor, ionotropic, NMDA1 (zeta 1), transcript variant 3 (from RefSeq NM_001177657.2) A2AI15 A2AI18 ENSMUST00000114312.1 Glurz1 NMDZ1_MOUSE NM_001177657 P35438 Q8CFS4 uc008iri.1 uc008iri.2 uc008iri.3 uc008iri.4 uc008iri.5 Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1532151, PubMed:8060614, PubMed:12008020). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:12008020). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B) (PubMed:12008020, PubMed:14602821). Found in a complex with GRIN2A or GRIN2B and GRIN3B (PubMed:12008020, PubMed:14602821). Found in a complex with GRIN2A or GRIN2B, GRIN3A and PPP2CB (By similarity). Interacts with DLG4 and MPDZ (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP (PubMed:18849881). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (PubMed:23524343). Found in a complex with DLG4 and PRR7 (By similarity). Found in a complex with GRIN2B and PRR7 (By similarity). Interacts with PRR7; the interaction is reduced following NMDA receptor activity (By similarity). P35438; Q62108: Dlg4; NbExp=13; IntAct=EBI-400084, EBI-300895; P35438; Q01097: Grin2b; NbExp=11; IntAct=EBI-400084, EBI-400125; P35438; Q924X6: Lrp8; NbExp=4; IntAct=EBI-400084, EBI-432319; P35438; P49769: Psen1; NbExp=3; IntAct=EBI-400084, EBI-990067; Cell membrane ulti-pass membrane protein Postsynaptic cell membrane Postsynaptic density Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P35438-1; Sequence=Displayed; Name=2; IsoId=P35438-2; Sequence=VSP_014222, VSP_014223; Detected in brain (at protein level). Detected in brain. A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter. NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By similarity). Mutant mice are born at the expected Mendelian rate, appear grossly normal and have apparently normal brain structure, but the pups do not feed and all die during the first day after birth. Cerebellum granule cells and hippocampus pyramidal neurons from mutants lack NMDA-induced Ca(2+)influx and membrane currents, contrary to wild- type. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. beta-amyloid binding conditioned taste aversion startle response suckling behavior response to amphetamine ionotropic glutamate receptor activity NMDA glutamate receptor activity receptor binding ion channel activity cation channel activity calcium channel activity calcium ion binding protein binding calmodulin binding cytoplasm endoplasmic reticulum plasma membrane integral component of plasma membrane ion transport cation transport calcium ion transport cellular calcium ion homeostasis chemical synaptic transmission learning or memory learning memory long-term memory synaptic vesicle associative learning adult locomotory behavior olfactory learning visual learning cell surface positive regulation of calcium ion transport into cytosol regulation of cell communication positive regulation of cell death postsynaptic density ligand-gated ion channel activity membrane integral component of membrane glycine binding glutamate binding NMDA selective glutamate receptor complex propylene metabolic process sensory perception of pain calcium-mediated signaling enzyme binding phosphatase binding pons maturation cerebral cortex development voltage-gated cation channel activity glutamate-gated calcium ion channel activity cell junction dendrite growth cone dendrite membrane social behavior ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic glutamate receptor binding signaling receptor activity neurotransmitter binding regulation of membrane potential neuronal cell body positive regulation of apoptotic process synaptic cleft terminal bouton dendritic spine response to morphine regulation of neuron apoptotic process negative regulation of neuron apoptotic process regulation of respiratory gaseous exchange dendritic branch macromolecular complex binding synapse postsynaptic membrane response to ethanol positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity regulation of synaptic plasticity regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity rhythmic process regulation of dendrite morphogenesis regulation of axonogenesis neuromuscular process protein tetramerization protein heterotetramerization regulation of synapse assembly calcium ion homeostasis excitatory synapse excitatory postsynaptic potential prepulse inhibition male mating behavior calcium ion transmembrane transport synaptic membrane calcium ion transmembrane import into cytosol postsynaptic density membrane glutamatergic synapse integral component of presynaptic membrane integral component of postsynaptic density membrane regulation of presynaptic membrane potential ligand-gated ion channel activity involved in regulation of presynaptic membrane potential positive regulation of Schwann cell migration positive regulation of dendritic spine maintenance positive regulation of reactive oxygen species biosynthetic process protein localization to postsynaptic membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential response to glycine positive regulation of excitatory postsynaptic potential positive regulation of cysteine-type endopeptidase activity uc008iri.1 uc008iri.2 uc008iri.3 uc008iri.4 uc008iri.5 
ENSMUST00000114313.8 Cflar ENSMUST00000114313.8 CASP8 and FADD-like apoptosis regulator, transcript variant 5 (from RefSeq NM_001293805.2) Cflar ENSMUST00000114313.1 ENSMUST00000114313.2 ENSMUST00000114313.3 ENSMUST00000114313.4 ENSMUST00000114313.5 ENSMUST00000114313.6 ENSMUST00000114313.7 NM_001293805 Q812G4 Q812G4_MOUSE uc007bcn.1 uc007bcn.2 uc007bcn.3 uc007bcn.4 uc007bcn.5 Belongs to the peptidase C14A family. response to hypoxia protease binding cysteine-type endopeptidase activity death receptor binding cytoplasm proteolysis apoptotic process enzyme activator activity cysteine-type peptidase activity negative regulation of cardiac muscle cell apoptotic process positive regulation of neuron projection development death-inducing signaling complex CD95 death-inducing signaling complex cellular response to insulin stimulus response to testosterone regulation of apoptotic process negative regulation of apoptotic process positive regulation of catalytic activity positive regulation of I-kappaB kinase/NF-kappaB signaling macromolecular complex binding membrane raft regulation of necroptotic process positive regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to dexamethasone stimulus cellular response to nitric oxide positive regulation of glomerular mesangial cell proliferation ripoptosome negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extracellular matrix organization negative regulation of reactive oxygen species biosynthetic process negative regulation of cellular response to transforming growth factor beta stimulus negative regulation of hepatocyte apoptotic process negative regulation of epithelial cell apoptotic process positive regulation of hepatocyte proliferation negative regulation of extrinsic apoptotic signaling pathway uc007bcn.1 uc007bcn.2 uc007bcn.3 uc007bcn.4 uc007bcn.5 
ENSMUST00000114321.2 Kbtbd2 ENSMUST00000114321.2 kelch repeat and BTB (POZ) domain containing 2, transcript variant 2 (from RefSeq NM_145958.2) ENSMUST00000114321.1 G3X9X1 KBTB2_MOUSE Kbtbd2 NM_145958 uc009cbm.1 uc009cbm.2 uc009cbm.3 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation. Protein modification; protein ubiquitination. Component of the BCR(KBTBD2) E3 ubiquitin ligase complex, at least composed of CUL3, KBTBD2 and RBX1 (PubMed:27708159). Interacts (via the BTB domain) with CUL3 (PubMed:27708159). Expressed at high levels in muscle, liver, brain, heart as well as white and brown adipose tissues. In adipose tissue, expression is inhibited by diet-induced obesity, the inhibition is mediated by leptin. Recognizes the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex substrate, PIK3R1, through the 4 tandem C-terminal Kelch domains. Mutants exhibit growth retardation, hyperglycemia, insulin resistance, lipodystrophy and hepatosteatosis (PubMed:27708159). Double knockouts for KBTBD2 and PIK3R1 have increased body weight, restored fat storage and decreased blood glucose and insulin (PubMed:27708159). Adipocyte-specific knockouts accumulate PIK3R1 in white and brown adipose tissues, causing insulin resistance, moderate rather than severe hyperglycemia, sustained hyperinsulinemia without late failure of insulin production and lipodystrophy leading to ectopic lipid accumulation in the liver. Adipocyte-extrinsic insulin resistance is observed in liver and muscle. None of these abnormalities are observed in liver- or muscle-specific knockout mice. Mice with knockout in adipocytes, liver and muscle show normal growth (PubMed:32381739). glucose metabolic process gene expression phosphatidylinositol 3-kinase signaling response to insulin uc009cbm.1 uc009cbm.2 uc009cbm.3 
ENSMUST00000114328.8 Tex28 ENSMUST00000114328.8 Belongs to the TEX28 family. (from UniProt B1AYN9) B1AYN9 B1AYN9_MOUSE ENSMUST00000114328.1 ENSMUST00000114328.2 ENSMUST00000114328.3 ENSMUST00000114328.4 ENSMUST00000114328.5 ENSMUST00000114328.6 ENSMUST00000114328.7 Tex28 uc292ovv.1 uc292ovv.2 Belongs to the TEX28 family. molecular_function cellular_component biological_process membrane integral component of membrane uc292ovv.1 uc292ovv.2 
ENSMUST00000114331.10 Mfsd10 ENSMUST00000114331.10 major facilitator superfamily domain containing 10, transcript variant 12 (from RefSeq NM_001412508.1) ENSMUST00000114331.1 ENSMUST00000114331.2 ENSMUST00000114331.3 ENSMUST00000114331.4 ENSMUST00000114331.5 ENSMUST00000114331.6 ENSMUST00000114331.7 ENSMUST00000114331.8 ENSMUST00000114331.9 MFS10_MOUSE NM_001412508 Q3U800 Q3UN73 Q9D1A7 Q9D2V8 Tetran uc008xcv.1 uc008xcv.2 uc008xcv.3 Probable organic anion transporter which may serve as a transporter for some non-steroidal anti-inflammatory drugs (NSAIDs) as well as other organic anions across the luminal membranes of renal proximal tubules at the final excretion step into the urine. Nucleus inner membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Esxpressed in luminal membrane of renal tubules (PubMed:18638446). Expressed at the surface of eosinophils (at protein level) (PubMed:22820041). Belongs to the major facilitator superfamily. nuclear inner membrane integral component of plasma membrane apoptotic process organic anion transmembrane transporter activity membrane integral component of membrane transmembrane transporter activity cytoplasmic vesicle membrane brush border membrane sodium-independent organic anion transport transmembrane transport uc008xcv.1 uc008xcv.2 uc008xcv.3 
ENSMUST00000114336.4 Tprn ENSMUST00000114336.4 taperin (from RefSeq NM_175286.4) A2AI08 ENSMUST00000114336.1 ENSMUST00000114336.2 ENSMUST00000114336.3 NM_175286 Q3TAJ8 Q3TMR8 Q5FWB3 Q7TNG3 Q8BNM5 Q8R1G4 TPRN_MOUSE uc008ira.1 uc008ira.2 uc008ira.3 uc008ira.4 Cell projection, stereocilium Note=Localized prominently at the taper regions of hair cell stereocilia. Expressed in the sensory epithelia of the organ of Corti and vestibular end organs and, to a lesser extent, in Reisner's membrane and the spiral ligament (at protein level). At postnatal day 2, expression is detected in cochlea, liver, brain, kidney, heart and lung. Belongs to the taperin family. Sequence=AAH89508.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC38669.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC38669.1; Type=Frameshift; Evidence=; Sequence=BAE38373.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE42670.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE42670.1; Type=Frameshift; Evidence=; molecular_function sensory perception of sound phosphatase binding stereocilium cell projection uc008ira.1 uc008ira.2 uc008ira.3 uc008ira.4 
ENSMUST00000114341.4 Gabrr3 ENSMUST00000114341.4 gamma-aminobutyric acid type A receptor subunit rho 3 (from RefSeq NM_001081190.1) B2RXA8 B2RXA8_MOUSE ENSMUST00000114341.1 ENSMUST00000114341.2 ENSMUST00000114341.3 Gabrr3 NM_001081190 uc007zpf.1 uc007zpf.2 uc007zpf.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane integral component of plasma membrane ion transport signal transduction chemical synaptic transmission membrane integral component of membrane protein domain specific binding ion transmembrane transport regulation of membrane potential neuron projection synapse neurological system process GABA-A receptor activity uc007zpf.1 uc007zpf.2 uc007zpf.3 
ENSMUST00000114349.9 Ndor1 ENSMUST00000114349.9 NADPH dependent diflavin oxidoreductase 1, transcript variant 1 (from RefSeq NM_001082476.2) A2AI05 ENSMUST00000114349.1 ENSMUST00000114349.2 ENSMUST00000114349.3 ENSMUST00000114349.4 ENSMUST00000114349.5 ENSMUST00000114349.6 ENSMUST00000114349.7 ENSMUST00000114349.8 NDOR1_MOUSE NM_001082476 Ndor1 Q3TQZ6 Q80WC5 uc008iqw.1 uc008iqw.2 uc008iqw.3 uc008iqw.4 NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair (By similarity). In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A (By similarity). Reaction=NADPH + 2 oxidized [2Fe-2S]-[protein] = H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]; Xref=Rhea:RHEA:67716, Rhea:RHEA- COMP:17327, Rhea:RHEA-COMP:17328, ChEBI:CHEBI:15378, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67717; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (By similarity). Interacts with DCPS (By similarity). Cytoplasm, perinuclear region te=Concentrated in perinuclear structure. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AI05-1; Sequence=Displayed; Name=2; IsoId=A2AI05-2; Sequence=VSP_031489; Name=3; IsoId=A2AI05-3; Sequence=VSP_031488, VSP_031490, VSP_031491; Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. NADPH-hemoprotein reductase activity nucleus cytoplasm cytosol cell death FMN binding iron-sulfur cluster assembly oxidoreductase activity oxidoreductase activity, acting on NAD(P)H cellular response to menadione intermediate filament cytoskeleton perinuclear region of cytoplasm flavin adenine dinucleotide binding NADP binding oxidation-reduction process uc008iqw.1 uc008iqw.2 uc008iqw.3 uc008iqw.4 
ENSMUST00000114354.10 Irak1 ENSMUST00000114354.10 interleukin-1 receptor-associated kinase 1, transcript variant 3 (from RefSeq NM_001177975.1) ENSMUST00000114354.1 ENSMUST00000114354.2 ENSMUST00000114354.3 ENSMUST00000114354.4 ENSMUST00000114354.5 ENSMUST00000114354.6 ENSMUST00000114354.7 ENSMUST00000114354.8 ENSMUST00000114354.9 Irak1 NM_001177975 Q8BR10 Q8BR10_MOUSE uc009tnq.1 uc009tnq.2 uc009tnq.3 uc009tnq.4 protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation signal transduction interleukin-1-mediated signaling pathway uc009tnq.1 uc009tnq.2 uc009tnq.3 uc009tnq.4 
ENSMUST00000114355.2 Rnf208 ENSMUST00000114355.2 ring finger protein 208 (from RefSeq NM_176834.2) A2AI04 B2FDG8 ENSMUST00000114355.1 NM_176834 Q8BTC4 Q8K0W3 RN208_MOUSE uc012bru.1 uc012bru.2 Sequence=AAH30073.1; Type=Erroneous initiation; Evidence=; ubiquitin-protein transferase activity nucleoplasm cytosol metal ion binding protein autoubiquitination uc012bru.1 uc012bru.2 
ENSMUST00000114366.3 Aox2 ENSMUST00000114366.3 aldehyde oxidase 2 (from RefSeq NM_001008419.2) AOXB_MOUSE Aoh3 Aox3l1 B9EKC6 ENSMUST00000114366.1 ENSMUST00000114366.2 NM_001008419 Q5SGK3 uc007bbp.1 uc007bbp.2 uc007bbp.3 Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as phthalazine, as well as aldehydes, such as benzaldehyde and retinal. Cannot use hypoxanthine as substrate. Reaction=an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2; Xref=Rhea:RHEA:16829, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067; EC=1.2.3.1; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 2 [2Fe-2S] clusters per subunit. ; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Evidence=; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. ; Homodimer. Cytoplasm Expressed in olfactory mucosa epithelium (at protein level). Detected in skin. AOX genes evolved from a xanthine oxidoreductase ancestral precursor via a series of gene duplication and suppression/deletion events. Different animal species contain a different complement of AOX genes encoding an equivalent number of AOX isoenzymes. In mammals, the two extremes are represented by certain rodents such as mice and rats, which are endowed with 4 AOX genes, and by humans, whose genome is characterized by a single active gene (PubMed:23263164). Belongs to the xanthine dehydrogenase family. aldehyde oxidase activity xanthine dehydrogenase activity iron ion binding cytoplasm cytosol electron carrier activity xanthine catabolic process oxidoreductase activity drug metabolic process electron transport chain protein homodimerization activity molybdopterin cofactor binding metal ion binding retinal oxidase activity flavin adenine dinucleotide binding NAD binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding oxidation-reduction process FAD binding uc007bbp.1 uc007bbp.2 uc007bbp.3 
ENSMUST00000114371.5 Cmss1 ENSMUST00000114371.5 cms small ribosomal subunit 1 (from RefSeq NM_025599.3) CMS1_MOUSE ENSMUST00000114371.1 ENSMUST00000114371.2 ENSMUST00000114371.3 ENSMUST00000114371.4 NM_025599 Q9CY77 Q9CZT6 uc007zng.1 uc007zng.2 uc007zng.3 uc007zng.4 Belongs to the CMS1 family. biological_process uc007zng.1 uc007zng.2 uc007zng.3 uc007zng.4 
ENSMUST00000114410.10 Kctd18 ENSMUST00000114410.10 potassium channel tetramerisation domain containing 18, transcript variant 1 (from RefSeq NM_001159864.1) E0CZ26 E0CZ26_MOUSE ENSMUST00000114410.1 ENSMUST00000114410.2 ENSMUST00000114410.3 ENSMUST00000114410.4 ENSMUST00000114410.5 ENSMUST00000114410.6 ENSMUST00000114410.7 ENSMUST00000114410.8 ENSMUST00000114410.9 Kctd18 NM_001159864 uc007bbf.1 uc007bbf.2 uc007bbf.3 uc007bbf.4 molecular_function cellular_component biological_process protein homooligomerization uc007bbf.1 uc007bbf.2 uc007bbf.3 uc007bbf.4 
ENSMUST00000114415.10 Satb2 ENSMUST00000114415.10 special AT-rich sequence binding protein 2, transcript variant 1 (from RefSeq NM_139146.3) ENSMUST00000114415.1 ENSMUST00000114415.2 ENSMUST00000114415.3 ENSMUST00000114415.4 ENSMUST00000114415.5 ENSMUST00000114415.6 ENSMUST00000114415.7 ENSMUST00000114415.8 ENSMUST00000114415.9 Kiaa1034 NM_139146 Q8VI24 SATB2_MOUSE uc007bas.1 uc007bas.2 uc007bas.3 Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double- stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating Bcl11b expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Interacts with PIAS1 (By similarity). Interacts with ATF4 and RUNX2; resulting in enhanced DNA binding and transactivation by these transcription factors. Q8VI24; P53564: Cux1; NbExp=3; IntAct=EBI-5737999, EBI-642309; Q8VI24; O09106: Hdac1; NbExp=4; IntAct=EBI-5737999, EBI-301912; Q8VI24; Q9R190: Mta2; NbExp=2; IntAct=EBI-5737999, EBI-904134; Q8VI24; Q60698: Ski; NbExp=3; IntAct=EBI-5737999, EBI-15969860; Q8VI24; P12755: SKI; Xeno; NbExp=2; IntAct=EBI-5737999, EBI-347281; Nucleus matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VI24-1; Sequence=Displayed; Name=2; IsoId=Q8VI24-2; Sequence=VSP_008967; Expressed in cortical neurons that extend axons across the corpus callosum. Also expressed in branchial arches and in cells of the osteoblast lineage, but not in chondrocytes and osteoclasts. Expression first detected at 10.5 dpc in the maxillary component of the first pharyngeal arch and the lateral aspect of the frontonasal process in the regions that will subsequently fuse to form the primary palate. At 11 - 11.5 dpc, the expression pattern demarcates the region of the medial aspect of the maxillary process within the primitive oral cavity, which will form the palate shelf. By 12.5 dpc, symmetrical expression is seen in the medial edges of the developing palate shelves and this continues until 13.5 dpc when the strongest expression is in the mesenchyme underlying the medial edge epithelia. By the time of palatal shelf fusion at 14.5 dpc the expression is dramatically down-regulated. No expression detected elsewhere in the embryo at any stage examined. Sumoylated by PIAS1. Sumoylation promotes nuclear localization, but represses transcription factor activity (By similarity). Malformations in 2 of the major axonal tracts interconnecting the cortical hemispheres: the corpus callosum (c.c) and the anterior commissure (a.c). Misrouted afferent and efferent cortical axon connections. Impaired migration of upper-layer neurons. Ectopic expression of Ctip2. Craniofacial abnormalities and defects in osteoblast differentiation and function. Belongs to the CUT homeobox family. Sequence=BAC98080.1; Type=Erroneous initiation; Evidence=; histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding neuron migration osteoblast development DNA binding chromatin binding protein binding nucleus nucleoplasm transcription factor complex chromatin organization chromatin remodeling multicellular organism development embryonic pattern specification regulation of gene expression nuclear matrix commitment of neuronal cell to specific neuron type in forebrain sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system morphogenesis cartilage development palate development cellular response to organic substance uc007bas.1 uc007bas.2 uc007bas.3 
ENSMUST00000114434.9 Hoxa3 ENSMUST00000114434.9 homeobox A3 (from RefSeq NM_010452.4) ENSMUST00000114434.1 ENSMUST00000114434.2 ENSMUST00000114434.3 ENSMUST00000114434.4 ENSMUST00000114434.5 ENSMUST00000114434.6 ENSMUST00000114434.7 ENSMUST00000114434.8 HXA3_MOUSE Hox-1.5 Hoxa-3 NM_010452 P02831 Q4V9Z8 Q61197 uc009bya.1 uc009bya.2 uc009bya.3 uc009bya.4 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds 5' to its own homeobox. Nucleus. Expressed in a spatially restricted manner in embryos 8.5 dpc, expression is limited to the CNS with an anterior boundary in the hindbrain and extending posteriorly through caudal regions of the spinal cord. The same spatial expression is seen in embryos 9.5 to 12.5 dpc. Belongs to the Antp homeobox family. RNA polymerase II core promoter proximal region sequence-specific DNA binding angiogenesis blood vessel remodeling DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development positive regulation of cell proliferation animal organ morphogenesis anterior/posterior pattern specification specification of animal organ position gene expression glossopharyngeal nerve morphogenesis thyroid gland development sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter thymus development animal organ formation embryonic skeletal system morphogenesis embryonic skeletal system development cartilage development parathyroid gland development HMG box domain binding positive regulation of receptor binding uc009bya.1 uc009bya.2 uc009bya.3 uc009bya.4 
ENSMUST00000114437.9 Ppp2r1b ENSMUST00000114437.9 protein phosphatase 2, regulatory subunit A, beta, transcript variant 2 (from RefSeq NM_028614.3) 2AAB_MOUSE E9QNJ1 ENSMUST00000114437.1 ENSMUST00000114437.2 ENSMUST00000114437.3 ENSMUST00000114437.4 ENSMUST00000114437.5 ENSMUST00000114437.6 ENSMUST00000114437.7 ENSMUST00000114437.8 NM_028614 Q7TNP2 uc009pkv.1 uc009pkv.2 uc009pkv.3 uc009pkv.4 The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9 (By similarity). Interacts with SGO1 (By similarity). Interacts with RAF1 (By similarity). Q7TNP2; Q8K1S3: Unc5b; NbExp=2; IntAct=EBI-4396871, EBI-4396886; Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure. Belongs to the phosphatase 2A regulatory subunit A family. protein phosphatase type 2A complex protein binding cytoplasm protein dephosphorylation protein phosphatase regulator activity regulation of phosphoprotein phosphatase activity membrane raft synapse apoptotic process involved in morphogenesis glutamatergic synapse positive regulation of extrinsic apoptotic signaling pathway in absence of ligand protein serine/threonine phosphatase activity uc009pkv.1 uc009pkv.2 uc009pkv.3 uc009pkv.4 
ENSMUST00000114444.9 Pcnp ENSMUST00000114444.9 PEST proteolytic signal containing nuclear protein, transcript variant 4 (from RefSeq NM_001024622.2) ENSMUST00000114444.1 ENSMUST00000114444.2 ENSMUST00000114444.3 ENSMUST00000114444.4 ENSMUST00000114444.5 ENSMUST00000114444.6 ENSMUST00000114444.7 ENSMUST00000114444.8 NM_001024622 PCNP_MOUSE Q6P8I4 uc007zma.1 uc007zma.2 uc007zma.3 May be involved in cell cycle regulation. Interacts with UHRF2/NIRF. Nucleus Ubiquitinated; mediated by UHRF2 and leading to its subsequent proteasomal degradation. N-terminally acetylated in a HYPK-dependent manner by the NatA acetyltransferase complex which is composed of NAA10 and NAA15. nucleus cell cycle protein ubiquitination nuclear body proteasome-mediated ubiquitin-dependent protein catabolic process uc007zma.1 uc007zma.2 uc007zma.3 
ENSMUST00000114449.7 Maea ENSMUST00000114449.7 macrophage erythroblast attacher (from RefSeq NM_021500.2) ENSMUST00000114449.1 ENSMUST00000114449.2 ENSMUST00000114449.3 ENSMUST00000114449.4 ENSMUST00000114449.5 ENSMUST00000114449.6 Emp MAEA_MOUSE NM_021500 Q3TFH0 Q3U7T6 Q4VC33 Q5XKE6 Q8BPI3 Q8BSA1 Q9JK49 uc008xaq.1 uc008xaq.2 uc008xaq.3 Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (PubMed:16707498). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis (PubMed:16707498, PubMed:17071116). Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (PubMed:16707498). May contribute to nuclear architecture and cells division events (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (By similarity). Interacts with F-actin (PubMed:16707498). Cytoplasm Nucleus, nucleoplasm Nucleus matrix Cell membrane Cytoplasm, cytoskeleton Note=Detected in a nuclear, speckled-like pattern (PubMed:17071116). Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis (By similarity). Present in cytoplasm, nuclear matrix and at the cell surface in macrophages; predominantly nuclear in immature macrophages and predominantly detected at the cell surface in mature macrophages (PubMed:17071116). Colocalizes with F-actin in macrophages (PubMed:16707498). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q4VC33-1; Sequence=Displayed; Name=2; IsoId=Q4VC33-2; Sequence=VSP_024797; Detected in embryonic fibroblasts (PubMed:16707498). Detected in macrophages (PubMed:17071116). Detected in heart. liver, spleen and kidney (at protein level) (PubMed:16510120). The expected RING-type zinc finger domain is highly divergent and most of the expected Cys residues are not conserved. Still, the protein is required for CTLH complex E3 ubiquitin-protein transferase activity. In addition, the conserved Cys-314 in this highly divergent region is required for ubiquitination by the yeast GID complex, suggesting a direct role in catalyzing ubiquitination. Autoubiquitinated as component of the CTLH E3 ubiquitin-protein ligase complex (in vitro). Mice die perinatally and exhibit profound alterations in the hematopoietic system. Blood of 14.5-16.5 dpc embryos contained mostly nucleated erythrocytes suggesting a defect in terminal maturation and enucleation of precursor cells. In the fetal liver, large immature erythroblasts predominate, macrophage exhibit an immature morphology and their number is reduced; No erythroblasts are attached to the macrophages suggesting impairment of erythroblastic island formation. Sequence=BAC35873.1; Type=Erroneous initiation; Evidence=; ubiquitin ligase complex actin binding nucleus nucleoplasm cytoplasm spindle actomyosin contractile ring cytoskeleton plasma membrane integral component of plasma membrane ubiquitin-dependent protein catabolic process cytoskeleton organization cell cycle cell adhesion actin cytoskeleton membrane nuclear matrix protein ubiquitination transferase activity negative regulation of myeloid cell apoptotic process GID complex negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process erythrocyte maturation negative regulation of gluconeogenesis metal ion binding erythrocyte development enucleate erythrocyte development cell division ubiquitin-protein transferase activity uc008xaq.1 uc008xaq.2 uc008xaq.3 
ENSMUST00000114457.8 Nfkbiz ENSMUST00000114457.8 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta, transcript variant 3 (from RefSeq NM_001159395.2) ENSMUST00000114457.1 ENSMUST00000114457.2 ENSMUST00000114457.3 ENSMUST00000114457.4 ENSMUST00000114457.5 ENSMUST00000114457.6 ENSMUST00000114457.7 IKBZ_MOUSE Inap Mail NM_001159395 Q3TVL7 Q3TWK9 Q3U8Y9 Q3UCI2 Q3URP0 Q3UW99 Q5NT97 Q99NA4 Q9EST8 uc007zlo.1 uc007zlo.2 uc007zlo.3 uc007zlo.4 Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895). Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895). Inhibits DNA- binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895). Seems also to activate NF-kappa-B-mediated transcription (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895). In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters (By similarity). Promotes transcription of LCN2 and DEFB4 (By similarity). Is recruited to IL-6 promoters and activates IL-6 but decreases TNF- alpha production in response to LPS (PubMed:11086164, PubMed:25107474). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (PubMed:11086164, PubMed:25107474). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (PubMed:25282160). Interacts with NFKB1/p50 (PubMed:11356851). Interacts with RELA (By similarity). Interacts with AKIRIN2 (PubMed:25107474). Q9EST8; B1AXD8: Akirin2; NbExp=3; IntAct=EBI-10107924, EBI-10107866; Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=MAIL-L; IsoId=Q9EST8-1; Sequence=Displayed; Name=2; Synonyms=MAIL-S; IsoId=Q9EST8-2; Sequence=VSP_032024; Name=3; Synonyms=D; IsoId=Q9EST8-3; Sequence=VSP_032025; Expressed in kidney, liver, lung and heart. Expressed at very low levels in skeletal muscle, spleen and brain. By IL-1, LPS, peptidoglycan, bacterial lipoprotein, flagellin, MALP-2, R-848 and CpG DNA, but not by TNF-alpha. Mice have splenocytes with defective proliferation in response to LPS but not to anti-CD40, IL-4 and anti- IgM. Though mice grew normally after birth, some of them started to develop atopic dermatitis-like skin lesions with acanthosis and lichenoid changes at the age of 4-5 weeks. All mice developed the disease by the age of 10 weeks. 5-week-old mice show pathological changes in the conjunctiva, including a heavy lymphocyte infiltration into the submucosa and loss of goblet cells in the conjunctival epithelium. [Isoform 1]: Major. Sequence=BAE24648.1; Type=Frameshift; Evidence=; protein binding nucleus inflammatory response nuclear speck cytoplasmic ribonucleoprotein granule positive regulation of inflammatory response T cell receptor signaling pathway positive regulation of T-helper 17 cell differentiation uc007zlo.1 uc007zlo.2 uc007zlo.3 uc007zlo.4 
ENSMUST00000114459.8 Hnrnpa2b1 ENSMUST00000114459.8 heterogeneous nuclear ribonucleoprotein A2/B1, transcript variant 4 (from RefSeq NM_001374745.1) B9EJ02 ENSMUST00000114459.1 ENSMUST00000114459.2 ENSMUST00000114459.3 ENSMUST00000114459.4 ENSMUST00000114459.5 ENSMUST00000114459.6 ENSMUST00000114459.7 Hnrpa2b1 NM_001374745 O88569 Q3UVJ5 Q6PCV9 Q8C2A0 Q8CJ71 Q91ZR9 Q9R204 ROA2_MOUSE uc291ekw.1 uc291ekw.2 Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (By similarity). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)- containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (By similarity). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity). Also plays a role in the activation of the innate immune response. Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6. In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). Homodimer; dimerization is required for nucleocytoplasmic translocation (PubMed:31320558). Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1. Interacts with C9orf72. Interacts with DGCR8. Interacts with TARDBP. Interacts with CKAP5. Interacts with TBK1 (PubMed:31320558). Interacts with STING1 (PubMed:31320558). Interacts with SRC (PubMed:31320558). Interacts with PPIA/CYPA (By similarity). Nucleus Nucleus, nucleoplasm Cytoplasm Cytoplasmic granule Secreted, extracellular exosome Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Not found in the nucleolus. Found in exosomes following sumoylation. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=B1; IsoId=O88569-1; Sequence=Displayed; Name=2; Synonyms=A2; IsoId=O88569-2; Sequence=VSP_022595; Name=3; IsoId=O88569-3; Sequence=VSP_022595, VSP_025012; The disordered region, when incubated at high concentration, is able to polymerize into labile, amyloid-like fibers and form cross-beta polymerization structures, probably driving the formation of hydrogels. In contrast to irreversible, pathogenic amyloids, the fibers polymerized from LC regions disassemble upon dilution. A number of evidence suggests that formation of cross-beta structures by LC regions mediate the formation of RNA granules, liquid-like droplets, and hydrogels. Sumoylated in exosomes, promoting miRNAs-binding. Asymmetric dimethylation at Arg-266 constitutes the major methylation site (By similarity). According to a report, methylation affects subcellular location and promotes nuclear localization (By similarity). According to another report, methylation at Arg-266 does not influence nucleocytoplasmic shuttling (By similarity). negative regulation of transcription from RNA polymerase II promoter mRNA splicing, via spliceosome chromosome, telomeric region chromatin regulatory region RNA binding nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding extracellular region nucleus nucleoplasm spliceosomal complex cytoplasm mRNA processing mRNA export from nucleus RNA splicing Cajal body telomere capping nuclear matrix primary miRNA processing miRNA binding identical protein binding neuron projection neuronal cell body single-stranded telomeric DNA binding perikaryon G-quadruplex DNA unwinding negative regulation of mRNA splicing, via spliceosome RNA transport mRNA transport extracellular exosome DNA polymerase binding catalytic step 2 spliceosome neuronal ribonucleoprotein granule pre-mRNA intronic binding G-rich strand telomeric DNA binding glutamatergic synapse postsynaptic cytosol positive regulation of telomere maintenance via telomere lengthening positive regulation of telomerase RNA reverse transcriptase activity N6-methyladenosine-containing RNA binding miRNA transport mRNA CDS binding ribonucleoprotein complex uc291ekw.1 uc291ekw.2 
ENSMUST00000114465.9 Slc6a8 ENSMUST00000114465.9 solute carrier family 6 (neurotransmitter transporter, creatine), member 8, transcript variant 3 (from RefSeq NM_001142810.1) A2ALM4 Crt ENSMUST00000114465.1 ENSMUST00000114465.2 ENSMUST00000114465.3 ENSMUST00000114465.4 ENSMUST00000114465.5 ENSMUST00000114465.6 ENSMUST00000114465.7 ENSMUST00000114465.8 NM_001142810 Q80YC9 Q8K4R3 Q8R1L0 Q8VBW1 SC6A8_MOUSE uc009tmh.1 uc009tmh.2 uc009tmh.3 uc009tmh.4 uc009tmh.5 Creatine:sodium symporter which mediates the uptake of creatine (PubMed:12439290). Plays an important role in supplying creatine to the brain via the blood-brain barrier (PubMed:12439290). Reaction=chloride(out) + creatine(out) + 2 Na(+)(out) = chloride(in) + creatine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71831, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57947; Evidence=; Kinetic parameters: KM=16.2 uM for creatine ; Vmax=0.10 nmol/min/mg enzyme for creatine ; Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=Q8VBW1-2; Sequence=Displayed; Name=1; IsoId=Q8VBW1-1; Sequence=VSP_061626; Name=3; IsoId=Q8VBW1-3; Sequence=VSP_061625; Brain. Highly expressed in brain capillaries branching in all cortical layers and moderately expressed in neuronal perikarya (at protein level). Glycosylated. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. creatine transmembrane transporter activity creatine:sodium symporter activity neurotransmitter:sodium symporter activity gamma-aminobutyric acid:sodium symporter activity plasma membrane integral component of plasma membrane ion transport sodium ion transport neurotransmitter transport choline transmembrane transporter activity symporter activity gamma-aminobutyric acid transport choline transport creatine transport membrane integral component of membrane neurotransmitter binding neuron projection glutamatergic synapse integral component of postsynaptic membrane embryonic brain development uc009tmh.1 uc009tmh.2 uc009tmh.3 uc009tmh.4 uc009tmh.5 
ENSMUST00000114472.8 Pnck ENSMUST00000114472.8 pregnancy upregulated non-ubiquitously expressed CaM kinase, transcript variant 3 (from RefSeq NM_001199352.1) ENSMUST00000114472.1 ENSMUST00000114472.2 ENSMUST00000114472.3 ENSMUST00000114472.4 ENSMUST00000114472.5 ENSMUST00000114472.6 ENSMUST00000114472.7 KCC1B_MOUSE NM_001199352 Q80W07 Q9QYK9 uc009tme.1 uc009tme.2 uc009tme.3 uc009tme.4 Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17; Activated by Ca(2+)/calmodulin. Cytoplasm Nucleus Expressed at highest levels in adult brain, and expressed in embryo. In the adult brain detected at high levels in the anterior olfactory nuclei, piriform cortex, septal nuclei, bed nuclei of the stria terminalis, hippocampal pyramidal cells, dentate granule cells, amygdala, hypothalamic nuclei, parabrachial nucleus, and nucleus of the solitary tract. Expressed at lower levels in adult ovary and heart and at very low levels in testis, lung and muscle. During embryogenesis detected at 10 dpc and expression gradually increases thereafter. Expressed mainly in the nervous system, including brain, spinal cord, trigeminal ganglion, and retina. Within the CNS detected in the mantle zone, but not in the ventricular zone. Detected at postnatal day 23 with highest levels in mesencephalon. Also expressed in developing bone and gut. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Sequence=AAH51996.1; Type=Erroneous initiation; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity calmodulin binding ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity uc009tme.1 uc009tme.2 uc009tme.3 uc009tme.4 
ENSMUST00000114482.3 Il1rn ENSMUST00000114482.3 interleukin 1 receptor antagonist, transcript variant 2 (from RefSeq NM_001039701.3) ENSMUST00000114482.1 ENSMUST00000114482.2 Il1rn NM_001039701 Q542C7 Q542C7_MOUSE uc008iox.1 uc008iox.2 uc008iox.3 uc008iox.4 Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. Secreted Belongs to the IL-1 family. cytokine activity interleukin-1 receptor binding interleukin-1, Type I receptor binding interleukin-1, Type II receptor binding interleukin-1 receptor antagonist activity extracellular region extracellular space inflammatory response immune response signal transduction negative regulation of heterotypic cell-cell adhesion interleukin-1 Type I receptor antagonist activity interleukin-1 Type II receptor antagonist activity response to glucocorticoid negative regulation of interleukin-1-mediated signaling pathway uc008iox.1 uc008iox.2 uc008iox.3 uc008iox.4 
ENSMUST00000114503.9 Xlr5c ENSMUST00000114503.9 Belongs to the XLR/SYCP3 family. (from UniProt A2AIE6) A2AIE6 A2AIE6_MOUSE BC119509 ENSMUST00000114503.1 ENSMUST00000114503.2 ENSMUST00000114503.3 ENSMUST00000114503.4 ENSMUST00000114503.5 ENSMUST00000114503.6 ENSMUST00000114503.7 ENSMUST00000114503.8 Xlr5c uc292oqu.1 uc292oqu.2 Belongs to the XLR/SYCP3 family. uc292oqu.1 uc292oqu.2 
ENSMUST00000114513.9 Gls ENSMUST00000114513.9 glutaminase, transcript variant 1 (from RefSeq NM_001081081.2) D3Z7P3 E9PUF0 ENSMUST00000114513.1 ENSMUST00000114513.2 ENSMUST00000114513.3 ENSMUST00000114513.4 ENSMUST00000114513.5 ENSMUST00000114513.6 ENSMUST00000114513.7 ENSMUST00000114513.8 GLSK_MOUSE Gls1 Kiaa0838 NM_001081081 Q69ZX9 uc007aye.1 uc007aye.2 uc007aye.3 uc007aye.4 uc007aye.5 Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain. Reaction=H2O + L-glutamine = L-glutamate + NH4(+); Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2; Evidence= Isoform 1 and isoform 2 are activated by phosphate, due to increased affinity for glutamine (PubMed:22228304, PubMed:23935106, PubMed:27542409). At phosphate concentrations above 10 mM, isoform 2 is more efficient than isoform 1. Homotetramer, dimer of dimers (PubMed:22228304, PubMed:27542409). The tetramers can assemble into rod-like oligomers (in vitro), but the physiological significance of this is not clear (PubMed:23935106). Interacts with RAF1 and MAP2K2 (By similarity). Interacts with ATCAY; the interaction is direct and may control GLS localization, negatively regulating its activity (PubMed:16899818). D3Z7P3-2; D3Z7P3-2: Gls; NbExp=3; IntAct=EBI-15962029, EBI-15962029; [Isoform 1]: Mitochondrion Cytoplasm, cytosol Note=The 74-kDa cytosolic precursor is translocated into the mitochondria and processed via a 72-kDa intermediate to yield the mature 68- and 65-kDa subunits. [Isoform 2]: Mitochondrion [Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix Note=Produced by the proteolytic processing of the 74-kDa cytosolic precursor. [Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix Note=Produced by the proteolytic processing of the 74-kDa cytosolic precursor. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=KGA ; IsoId=D3Z7P3-1; Sequence=Displayed; Name=2; Synonyms=Glutaminase C , GAC ; IsoId=D3Z7P3-2; Sequence=VSP_043804; A highly mobile activation loop at the dimer-dimer interface is important for enzyme activity. The C-terminal ANK repeats prevent the assembly of the supra- tetrameric filaments. Synthesized as a 74-kDa cytosolic precursor which is proteolytically processed by the mitochondrial-processing peptidase (MPP) via a 72-kDa intermediate to yield the mature mitochondrial 68- and 65-kDa subunits. Death during the first days after birth. Pups appear normal and display normal levels of activity, but their activity is disorganized. Pups do not orient to the dam, do not succeed in grasping a nipple and do not feed properly. In addition, they display altered respiration. Belongs to the glutaminase family. Sequence=BAD32317.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; suckling behavior regulation of respiratory gaseous exchange by neurological system process glutaminase activity protein binding cytoplasm mitochondrion mitochondrial matrix cytosol glutamate biosynthetic process glutamine metabolic process glutamine catabolic process chemical synaptic transmission hydrolase activity identical protein binding protein homotetramerization glutamate homeostasis uc007aye.1 uc007aye.2 uc007aye.3 uc007aye.4 uc007aye.5 
ENSMUST00000114517.2 Spin2d ENSMUST00000114517.2 spindlin family, member 2D (from RefSeq NM_001243002.1) 4930408F14Rik B1B0R2 B1B0R2_MOUSE ENSMUST00000114517.1 NM_001243002 Spin2d uc029xko.1 uc029xko.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation biological_process methylated histone binding uc029xko.1 uc029xko.2 
ENSMUST00000114518.9 Xlr5b ENSMUST00000114518.9 X-linked lymphocyte-regulated 5B (from RefSeq NM_001111293.1) A2BI50 A2BI50_MOUSE ENSMUST00000114518.1 ENSMUST00000114518.2 ENSMUST00000114518.3 ENSMUST00000114518.4 ENSMUST00000114518.5 ENSMUST00000114518.6 ENSMUST00000114518.7 ENSMUST00000114518.8 NM_001111293 Xlr5b uc012hka.1 uc012hka.2 uc012hka.3 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc012hka.1 uc012hka.2 uc012hka.3 
ENSMUST00000114524.9 Xlr3a ENSMUST00000114524.9 Belongs to the XLR/SYCP3 family. (from UniProt Q78PE0) BC093495 ENSMUST00000114524.1 ENSMUST00000114524.2 ENSMUST00000114524.3 ENSMUST00000114524.4 ENSMUST00000114524.5 ENSMUST00000114524.6 ENSMUST00000114524.7 ENSMUST00000114524.8 Q78PE0 Q78PE0_MOUSE Xlr3 Xlr3a uc292opw.1 uc292opw.2 Belongs to the XLR/SYCP3 family. uc292opw.1 uc292opw.2 
ENSMUST00000114526.9 Acbd5 ENSMUST00000114526.9 acyl-Coenzyme A binding domain containing 5, transcript variant 27 (from RefSeq NR_176080.1) A2AQX9 A2AQY0 ACBD5_MOUSE ENSMUST00000114526.1 ENSMUST00000114526.2 ENSMUST00000114526.3 ENSMUST00000114526.4 ENSMUST00000114526.5 ENSMUST00000114526.6 ENSMUST00000114526.7 ENSMUST00000114526.8 NR_176080 Q5XG73 Q6P7V7 Q7TSC2 Q8BKU6 Q8CI99 Q9CW41 uc008inz.1 uc008inz.2 uc008inz.3 uc008inz.4 Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity). Peroxisome membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5XG73-1; Sequence=Displayed; Name=2; IsoId=Q5XG73-2; Sequence=VSP_025450; Name=3; IsoId=Q5XG73-3; Sequence=VSP_025450, VSP_025451; Belongs to the ATG37 family. Sequence=AAH35202.1; Type=Erroneous initiation; Evidence=; Sequence=AAH53518.1; Type=Erroneous initiation; Evidence=; fatty-acyl-CoA binding molecular_function nucleus nucleoplasm peroxisome peroxisomal membrane autophagy lipid binding membrane integral component of membrane pexophagy uc008inz.1 uc008inz.2 uc008inz.3 uc008inz.4 
ENSMUST00000114540.4 Pnma5 ENSMUST00000114540.4 paraneoplastic antigen family 5 (from RefSeq NM_001100461.3) A2BI36 ENSMUST00000114540.1 ENSMUST00000114540.2 ENSMUST00000114540.3 Kiaa1934 NM_001100461 PNMA5_MOUSE Q5DTT8 uc012hjz.1 uc012hjz.2 Restricted to testis, where expression is low. Not detected in the brain. Belongs to the PNMA family. Sequence=BAD90475.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cellular_component biological_process identical protein binding uc012hjz.1 uc012hjz.2 
ENSMUST00000114544.10 Abi1 ENSMUST00000114544.10 abl interactor 1, transcript variant 28 (from RefSeq NM_001416866.1) ABI1_MOUSE Abi1 ENSMUST00000114544.1 ENSMUST00000114544.2 ENSMUST00000114544.3 ENSMUST00000114544.4 ENSMUST00000114544.5 ENSMUST00000114544.6 ENSMUST00000114544.7 ENSMUST00000114544.8 ENSMUST00000114544.9 NM_001416866 Q3U8V0 Q60747 Q8CBW3 Q91ZM5 Q923I9 Q99KH4 Ssh3bp1 uc008inw.1 uc008inw.2 uc008inw.3 uc008inw.4 May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF- induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. Interacts with ENAH, Abelson murine leukemia virus V-ABL, ABL1, STX1A, SNAP25, VAMP2, and through its N-terminus with WASF1. Part of a complex consisting of ABI1, STX1A and SNAP25. Part of a complex consisting of ABI1, EPS8 and SOS1. Interacts with EPS8, SOS1, SOS2, GRB2, SPTA1, and the first SH3 domain of NCK1 (By similarity). Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2. Interacts (via SH3 domain) with SHANK2 and SHANK3, but not SHANK1; the interaction is direct. Interacts with the heterodimer MYC:MAX; the interaction may enhance MYC:MAX transcriptional activity. Interacts with FNBP1L (via the SH3 domain), WASF2, and CDC42, but only in the presence of FNBP1L (By similarity). Q8CBW3; Q9Z207: Diaph3; NbExp=2; IntAct=EBI-375511, EBI-6550123; Q8CBW3; Q08509: Eps8; NbExp=3; IntAct=EBI-375511, EBI-375596; Q8CBW3; Q02384: Sos2; NbExp=2; IntAct=EBI-375511, EBI-395573; Q8CBW3; Q8BH43: Wasf2; NbExp=2; IntAct=EBI-375511, EBI-643162; Cytoplasm Nucleus Cell projection, lamellipodium Cell projection, filopodium Cell projection, growth cone Postsynaptic density Cytoplasm, cytoskeleton Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity). Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8CBW3-1; Sequence=Displayed; Name=2; Synonyms=short; IsoId=Q8CBW3-2; Sequence=VSP_010756, VSP_010757, VSP_010758; Name=3; IsoId=Q8CBW3-3; Sequence=VSP_010756; Name=4; Synonyms=long; IsoId=Q8CBW3-4; Sequence=VSP_010756, VSP_010757; Name=5; IsoId=Q8CBW3-5; Sequence=VSP_010756, VSP_022636; Widely expressed with highest levels in bone marrow, spleen, brain, testes, and embryonic brain. In adult brain prominently expressed in the neocortex, hippocampus and dentate gyrus. Detected at 10 dpc and 12 dpc in developing brain, but does not appear more prominent in the neuroepithelium compared to the surrounding tissue. The t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with STX1A. Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl. Seems to be phosphorylated at Tyr-53 by ABL1, required for nuclear but not for synaptic localization (By similarity). Belongs to the ABI family. somitogenesis protein binding nucleus cytoplasm cytoskeleton plasma membrane transcription factor binding actin polymerization or depolymerization postsynaptic density membrane SH3 domain binding peptidyl-tyrosine phosphorylation lamellipodium cell junction filopodium protein tyrosine kinase activator activity growth cone SCAR complex cell leading edge filopodium tip megakaryocyte development cell projection neuron projection synapse postsynaptic membrane dendrite morphogenesis positive regulation of protein tyrosine kinase activity lamellipodium morphogenesis glutamatergic synapse postsynapse to nucleus signaling pathway uc008inw.1 uc008inw.2 uc008inw.3 uc008inw.4 
ENSMUST00000114545.8 Lrrc61 ENSMUST00000114545.8 leucine rich repeat containing 61, transcript variant 1 (from RefSeq NM_177736.4) A0A0R4J1J6 A0A0R4J1J6_MOUSE ENSMUST00000114545.1 ENSMUST00000114545.2 ENSMUST00000114545.3 ENSMUST00000114545.4 ENSMUST00000114545.5 ENSMUST00000114545.6 ENSMUST00000114545.7 Lrrc61 NM_177736 uc012elf.1 uc012elf.2 uc012elf.3 uc012elf.1 uc012elf.2 uc012elf.3 
ENSMUST00000114551.10 Cetn2 ENSMUST00000114551.10 centrin 2 (from RefSeq NM_019405.7) B1AUQ6 B1AUQ8 CETN2_MOUSE Calt ENSMUST00000114551.1 ENSMUST00000114551.2 ENSMUST00000114551.3 ENSMUST00000114551.4 ENSMUST00000114551.5 ENSMUST00000114551.6 ENSMUST00000114551.7 ENSMUST00000114551.8 ENSMUST00000114551.9 NM_019405 Q3UBB4 Q9CWM0 Q9R1K9 uc009tku.1 uc009tku.2 uc009tku.3 Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity). Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with Rad23b appears to stabilize Xpc. In vitro, stimulates DNA binding of the Xpc:Rad23b dimer (By similarity). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Monomer. Homooligomer. Interacts with CCP110, SFI1. Component of the XPC complex composed of XPC, RAD23B and CETN2 (By similarity). Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, 2 copies of ENY2, PCID2, SEM1/DSS1, and either centrin CETN2 or centrin CETN3. The TREX-2 complex also associates with ALYREF/ALY and with the nucleoporin NUP153 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Nucleus Nucleus envelope Nucleus, nuclear pore complex Ubiquitously expressed in all adult tissues tested, with strongest expression in brain, spleen, kidney, small intestine and ovary. Also expressed in the NIH 3T3 fibroblast cell line and peripheral blood lymphocytes. Binds two moles of calcium per mole of protein. Belongs to the centrin family. Sequence=CAM20357.1; Type=Erroneous gene model prediction; Evidence=; mitotic cell cycle calcium ion binding nucleus nuclear envelope nuclear pore cytoplasm centrosome centriole microtubule organizing center cytoskeleton cilium DNA repair nucleotide-excision repair cellular response to DNA damage stimulus cell cycle centriole replication spermatogenesis microtubule binding protein transport G-protein beta/gamma-subunit complex binding photoreceptor connecting cilium regulation of cytokinesis heterotrimeric G-protein binding ciliary basal body nuclear pore nuclear basket metal ion binding mRNA transport cell division transcription export complex 2 XPC complex uc009tku.1 uc009tku.2 uc009tku.3 
ENSMUST00000114561.9 Zfp467 ENSMUST00000114561.9 zinc finger protein 467, transcript variant 1 (from RefSeq NM_020589.2) ENSMUST00000114561.1 ENSMUST00000114561.2 ENSMUST00000114561.3 ENSMUST00000114561.4 ENSMUST00000114561.5 ENSMUST00000114561.6 ENSMUST00000114561.7 ENSMUST00000114561.8 Ezi MNCb-3350 NM_020589 Q8JZL0 Q9JJ98 ZN467_MOUSE Znf467 uc009buh.1 uc009buh.2 Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex. Interacts with STAT3. Enhances STAT3 activity by keeping it in the nucleus. Nucleus Down-regulated by CTF1, PTH and OSM. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAA95099.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding protein binding nucleus regulation of transcription, DNA-templated metal ion binding uc009buh.1 uc009buh.2 
ENSMUST00000114562.3 Tmprss7 ENSMUST00000114562.3 transmembrane serine protease 7 (from RefSeq NM_172455.3) E9QME7 ENSMUST00000114562.1 ENSMUST00000114562.2 NM_172455 Q4PPC3 Q8BIK6 TMPS7_MOUSE uc007ziv.1 uc007ziv.2 uc007ziv.3 Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position. Kinetic parameters: KM=240 nM for Suc-Ala-Ala-Pro-Arg-pNA ; KM=534 nM for Suc-Ala-Ala-Pro-Lys-pNA ; Forms a heterodimer with SERPINA5. Cell membrane ; Single-pass type II membrane protein Expressed in brain, eye, testis, skin, epididymis and salivary gland with lower levels in heart, skeletal muscle, thymus, ovary, prostate and uterus. N-glycosylated. Belongs to the peptidase S1 family. Sequence=BAC32448.1; Type=Frameshift; Evidence=; Sequence=BAC32448.1; Type=Miscellaneous discrepancy; Note=Differs at the N-terminus for unknown reasons.; Evidence=; serine-type endopeptidase activity protein binding plasma membrane proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc007ziv.1 uc007ziv.2 uc007ziv.3 
ENSMUST00000114572.9 Krba1 ENSMUST00000114572.9 KRAB-A domain containing 1, transcript variant 1 (from RefSeq NM_001347152.1) A0A140T8R3 A0A140T8R3_MOUSE ENSMUST00000114572.1 ENSMUST00000114572.2 ENSMUST00000114572.3 ENSMUST00000114572.4 ENSMUST00000114572.5 ENSMUST00000114572.6 ENSMUST00000114572.7 ENSMUST00000114572.8 Krba1 NM_001347152 uc009bua.1 uc009bua.2 uc009bua.3 uc009bua.4 nucleic acid binding regulation of transcription, DNA-templated uc009bua.1 uc009bua.2 uc009bua.3 uc009bua.4 
ENSMUST00000114574.3 Glp1r ENSMUST00000114574.3 glucagon-like peptide 1 receptor (from RefSeq NM_021332.2) ENSMUST00000114574.1 ENSMUST00000114574.2 GLP1R_MOUSE NM_021332 O35659 Q1JQR8 uc008bud.1 uc008bud.2 uc008bud.3 G-protein coupled receptor for glucagon-like peptide 1 (GLP- 1) (PubMed:9568699). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (By similarity). Plays a role in regulating insulin secretion in response to GLP-1 (PubMed:9568699). May form homodimers and heterodimers with GIPR. Cell membrane ; Multi-pass membrane protein Detected in pancreatic islets (at protein level). Detected in pancreatic islets and lungs. N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER. Belongs to the G-protein coupled receptor 2 family. Sequence=CAA04930.1; Type=Frameshift; Evidence=; peptide receptor activity transmembrane signaling receptor activity G-protein coupled receptor activity glucagon receptor activity plasma membrane integral component of plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway learning or memory memory feeding behavior regulation of heart contraction positive regulation of cell proliferation associative learning G-protein coupled peptide receptor activity response to glucose membrane integral component of membrane peptide hormone binding cAMP-mediated signaling insulin secretion positive regulation of insulin secretion signaling receptor activity negative regulation of apoptotic process negative regulation of neuron apoptotic process glucagon-like peptide 1 receptor activity positive regulation of cell differentiation positive regulation of blood pressure positive regulation of heart contraction positive regulation of transcription from RNA polymerase II promoter hormone secretion release of sequestered calcium ion into cytosol regulation of calcium ion transport cellular response to glucagon stimulus response to psychosocial stress uc008bud.1 uc008bud.2 uc008bud.3 
ENSMUST00000114576.9 Vma21 ENSMUST00000114576.9 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), transcript variant 2 (from RefSeq NM_001081356.3) ENSMUST00000114576.1 ENSMUST00000114576.2 ENSMUST00000114576.3 ENSMUST00000114576.4 ENSMUST00000114576.5 ENSMUST00000114576.6 ENSMUST00000114576.7 ENSMUST00000114576.8 NM_001081356 Q3UUC3 Q78T54 VMA21_MOUSE uc009tkf.1 uc009tkf.2 uc009tkf.3 uc009tkf.4 Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. Associates with the V0 complex of the vacuolar ATPase (V- ATPase) (By similarity). Interacts with ATP6AP2 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Cytoplasmic vesicle, COPII-coated vesicle membrane ulti-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q78T54-1; Sequence=Displayed; Name=2; IsoId=Q78T54-2; Sequence=VSP_037464; Belongs to the VMA21 family. vacuole endoplasmic reticulum endoplasmic reticulum membrane ER to Golgi transport vesicle membrane membrane integral component of membrane cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment membrane vacuolar proton-transporting V-type ATPase complex assembly uc009tkf.1 uc009tkf.2 uc009tkf.3 uc009tkf.4 
ENSMUST00000114585.3 Cd200l1 ENSMUST00000114585.3 CD200 molecule like 1 (from RefSeq NM_001005854.2) Cd200l1 E9Q573 E9Q573_MOUSE ENSMUST00000114585.1 ENSMUST00000114585.2 Gm609 NM_001005854 uc007zip.1 uc007zip.2 membrane integral component of membrane uc007zip.1 uc007zip.2 
ENSMUST00000114590.8 Zfp513 ENSMUST00000114590.8 zinc finger protein 513, transcript variant 1 (from RefSeq NM_175311.4) ENSMUST00000114590.1 ENSMUST00000114590.2 ENSMUST00000114590.3 ENSMUST00000114590.4 ENSMUST00000114590.5 ENSMUST00000114590.6 ENSMUST00000114590.7 NM_175311 Q3U4K1 Q6PD29 Q8BWH6 ZN513_MOUSE Znf513 uc008wxo.1 uc008wxo.2 uc008wxo.3 Transcriptional regulator that plays a role in retinal development and maintenance. Binds DNA. Can associate with the proximal promoter regions of PAX6 and SP4, and their known targets including ARR3, RHO, OPN1MW2 and OPN1SW. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PD29-1; Sequence=Displayed; Name=2; IsoId=Q6PD29-2; Sequence=VSP_035626; Widely expressed. In the eye, expression is greatest in the retina and least in the lens and cornea. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAH58976.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC35001.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated transcription regulatory region DNA binding metal ion binding retina development in camera-type eye uc008wxo.1 uc008wxo.2 uc008wxo.3 
ENSMUST00000114629.4 Mamld1 ENSMUST00000114629.4 mastermind-like domain containing 1, transcript variant 2 (from RefSeq NM_001256048.1) D3Z768 D3Z768_MOUSE ENSMUST00000114629.1 ENSMUST00000114629.2 ENSMUST00000114629.3 Mamld1 NM_001256048 uc012hjo.1 uc012hjo.2 uc012hjo.3 uc012hjo.1 uc012hjo.2 uc012hjo.3 
ENSMUST00000114630.3 Tmem185a ENSMUST00000114630.3 transmembrane protein 185A, transcript variant 1 (from RefSeq NM_001357750.1) A2AF53 ENSMUST00000114630.1 ENSMUST00000114630.2 Ee3 Fam11a NM_001357750 T185A_MOUSE uc012hjm.1 uc012hjm.2 uc012hjm.3 Interacts with MAP1B. Cell projection, dendrite Membrane ; Multi-pass membrane protein Broadly expressed in brain where it is specifically expressed by neurons (at protein level). Also detected in some cells of arterioles, intestine, lung and testis (at protein level). Detected at 7 dpc, levels increase from 11 dpc to 17 dpc. Up-regulated by erythropoietin (at protein level). Belongs to the TMEM185 family. molecular_function biological_process membrane integral component of membrane dendrite cell projection uc012hjm.1 uc012hjm.2 uc012hjm.3 
ENSMUST00000114634.3 Boc ENSMUST00000114634.3 BOC cell adhesion associated, oncogene regulated (from RefSeq NM_172506.2) Boc D3Z763 D3Z763_MOUSE ENSMUST00000114634.1 ENSMUST00000114634.2 NM_172506 uc007zhl.1 uc007zhl.2 uc007zhl.3 nucleoplasm integral component of plasma membrane smoothened signaling pathway axon guidance membrane integral component of membrane axonal growth cone positive regulation of myoblast differentiation uc007zhl.1 uc007zhl.2 uc007zhl.3 
ENSMUST00000114641.8 Cntnap2 ENSMUST00000114641.8 contactin associated protein-like 2, transcript variant 1 (from RefSeq NM_001004357.2) Cntnap2 E9QNF7 E9QNF7_MOUSE ENSMUST00000114641.1 ENSMUST00000114641.2 ENSMUST00000114641.3 ENSMUST00000114641.4 ENSMUST00000114641.5 ENSMUST00000114641.6 ENSMUST00000114641.7 NM_001004357 uc009bst.1 uc009bst.2 uc009bst.3 uc009bst.4 uc009bst.5 Cell junction, paranodal septate junction Membrane ; Single-pass type I membrane protein Belongs to the neurexin family. Lacks conserved residue(s) required for the propagation of feature annotation. early endosome Golgi apparatus learning voltage-gated potassium channel complex cell surface membrane integral component of membrane enzyme binding striatum development limbic system development thalamus development cerebral cortex development adult behavior axolemma social behavior vocal learning superior temporal gyrus development protein localization to juxtaparanode region of axon vocalization behavior uc009bst.1 uc009bst.2 uc009bst.3 uc009bst.4 uc009bst.5 
ENSMUST00000114655.8 Fmr1 ENSMUST00000114655.8 Cell membrane Cell projection, axon Cell projection, dendrite Cell projection, dendritic spine Cell projection, filopodium tip Cell projection, growth cone Cell projection, neuron projection Chromosome, centromere Cytoplasm, Cytoplasmic ribonucleoprotein granule Cytoplasm, Stress granule Cytoplasm, perinuclear region Membrane Nucleus, nucleolus Perikaryon Presynaptic cell membrane Synapse, synaptosome Synaptic cell membrane (from UniProt E9QAS8) BC079671 E9QAS8 E9QAS8_MOUSE ENSMUST00000114655.1 ENSMUST00000114655.2 ENSMUST00000114655.3 ENSMUST00000114655.4 ENSMUST00000114655.5 ENSMUST00000114655.6 ENSMUST00000114655.7 Fmr1 uc292omd.1 uc292omd.2 Cell membrane Cell projection, axon Cell projection, dendrite Cell projection, dendritic spine Cell projection, filopodium tip Cell projection, growth cone Cell projection, neuron projection Chromosome, centromere Cytoplasm, Cytoplasmic ribonucleoprotein granule Cytoplasm, Stress granule Cytoplasm, perinuclear region Membrane Nucleus, nucleolus Perikaryon Presynaptic cell membrane Synapse, synaptosome Synaptic cell membrane Belongs to the FMR1 family. nucleic acid binding RNA binding mRNA binding regulation of translation uc292omd.1 uc292omd.2 
ENSMUST00000114664.8 Mpzl3 ENSMUST00000114664.8 myelin protein zero-like 3 (from RefSeq NM_001093749.3) A5H7F1 ENSMUST00000114664.1 ENSMUST00000114664.2 ENSMUST00000114664.3 ENSMUST00000114664.4 ENSMUST00000114664.5 ENSMUST00000114664.6 ENSMUST00000114664.7 MPZL3_MOUSE NM_001093749 Q3V3F6 uc009pfc.1 uc009pfc.2 uc009pfc.3 uc009pfc.4 Mediates homophilic cell-cell adhesion. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3V3F6-1; Sequence=Displayed; Name=2; IsoId=Q3V3F6-2; Sequence=VSP_023606, VSP_023607; Present in all tissues tested, including the skin. Present in the keratinocytes and sebocytes in the skin (at protein level). Note=Defects in Mpzl3 are the cause of rough coat (rc) phenotype, an autosomal-recessive mutation, arose spontaneously in C57BL/6J mice. Rc mice develop severe skin and hair abnormalities, including cyclic and progressive hair loss and sebaceous gland hypertrophy. Belongs to the myelin P0 protein family. cell adhesion membrane integral component of membrane extracellular matrix organization hair cycle uc009pfc.1 uc009pfc.2 uc009pfc.3 uc009pfc.4 
ENSMUST00000114666.9 Atp6v1a ENSMUST00000114666.9 ATPase, H+ transporting, lysosomal V1 subunit A, transcript variant 3 (from RefSeq NM_007508.6) Atp6a1 Atp6a2 Atp6v1a1 ENSMUST00000114666.1 ENSMUST00000114666.2 ENSMUST00000114666.3 ENSMUST00000114666.4 ENSMUST00000114666.5 ENSMUST00000114666.6 ENSMUST00000114666.7 ENSMUST00000114666.8 NM_007508 P50516 Q3TKS0 Q3U5W3 Q3U777 Q3UDZ9 Q3US31 Q8CHX2 VATA_MOUSE uc007zgu.1 uc007zgu.2 uc007zgu.3 Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:23863464). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in neurite development and synaptic connectivity (By similarity). Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate; Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2; Evidence=; ATP hydrolysis occurs at the interface between the nucleotide-binding domains of subunits A and B (By similarity). ATP hydrolysis triggers a conformational change in the subunits D and F, which induces a shift of subunit d (By similarity). The c-ring is subsequently rotated and results in a continuous proton translocation across the membrane (By similarity). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with the V0 complex V-ATPase subunit a4 ATP6V0A4 (PubMed:11495928). Interacts with WFS1 (By similarity). Interacts with alpha-crystallin B chain/CRYAB and with MTOR, forming a ternary complex (PubMed:31786107). Cytoplasm Cytoplasm, cytosol Cytoplasmic vesicle, secretory vesicle Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein Lysosome Note=Co-localizes with WFS1 in the secretory granules in neuroblastoma cell lines. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50516-1; Sequence=Displayed; Name=2; IsoId=P50516-2; Sequence=VSP_024628, VSP_024629; Phosphorylation at Ser-384 by AMPK down-regulates its enzyme activity. Belongs to the ATPase alpha/beta chains family. nucleotide binding ATP binding cytoplasm mitochondrion vacuolar membrane cytosol plasma membrane microvillus ion transport cellular iron ion homeostasis apical plasma membrane proton-transporting V-type ATPase, V1 domain cellular response to increased oxygen levels myelin sheath ATP metabolic process proton-transporting ATPase activity, rotational mechanism hydrogen ion transmembrane transport uc007zgu.1 uc007zgu.2 uc007zgu.3 
ENSMUST00000114672.2 Gm14692 ENSMUST00000114672.2 predicted gene 14692 (from RefSeq NM_001163195.1) A2BH01 A2BH01_MOUSE ENSMUST00000114672.1 Gm1140 Gm14692 NM_001163195 uc012hjb.1 uc012hjb.2 uc012hjb.3 uc012hjb.4 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc012hjb.1 uc012hjb.2 uc012hjb.3 uc012hjb.4 
ENSMUST00000114675.2 Gm1140 ENSMUST00000114675.2 predicted gene 1140 (from RefSeq NM_001126317.1) A2BH01 A2BH01_MOUSE ENSMUST00000114675.1 Gm1140 Gm14692 NM_001126317 uc012hja.1 uc012hja.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc012hja.1 uc012hja.2 
ENSMUST00000114682.4 Gm6760 ENSMUST00000114682.4 predicted gene 6760 (from RefSeq NM_001177377.1) EG627470 ENSMUST00000114682.1 ENSMUST00000114682.2 ENSMUST00000114682.3 Gm6760 NM_001177377 Q0ZNK3 Q0ZNK3_MOUSE uc009tim.1 uc009tim.2 uc009tim.3 uc009tim.4 molecular_function cellular_component biological_process uc009tim.1 uc009tim.2 uc009tim.3 uc009tim.4 
ENSMUST00000114694.9 Zbtb20 ENSMUST00000114694.9 zinc finger and BTB domain containing 20, transcript variant 3 (from RefSeq NM_001285805.1) A6X916 ENSMUST00000114694.1 ENSMUST00000114694.2 ENSMUST00000114694.3 ENSMUST00000114694.4 ENSMUST00000114694.5 ENSMUST00000114694.6 ENSMUST00000114694.7 ENSMUST00000114694.8 NM_001285805 Q8K0L9 Q9DBD4 Q9QZ87 ZBT20_MOUSE Zfp288 uc289esi.1 uc289esi.2 May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912). Can homodimerize. Binds to DNA. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=HOF-L; IsoId=Q8K0L9-1; Sequence=Displayed; Name=2; Synonyms=HOF-S; IsoId=Q8K0L9-2; Sequence=VSP_032504; Specifically expressed in early hippocampal neurons, cerebellar granule cells and gliogenic progenitors as well as in differentiated glia (PubMed:11744704). Expressed in adult and aged myogenic satellite cells (PubMed:27446912). Not expressed during development, is induced during establishment of satellite cells and acquisition of quiescence. Sumoylated with SUMO1. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus nucleoplasm cytoplasm negative regulation of gene expression nuclear body positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production transcription regulatory region DNA binding positive regulation of glycolytic process negative regulation of transcription, DNA-templated metal ion binding positive regulation of lipid biosynthetic process lipid homeostasis cellular response to glucose stimulus uc289esi.1 uc289esi.2 
ENSMUST00000114701.10 Pi16 ENSMUST00000114701.10 peptidase inhibitor 16 (from RefSeq NM_023734.3) Cripi ENSMUST00000114701.1 ENSMUST00000114701.2 ENSMUST00000114701.3 ENSMUST00000114701.4 ENSMUST00000114701.5 ENSMUST00000114701.6 ENSMUST00000114701.7 ENSMUST00000114701.8 ENSMUST00000114701.9 NM_023734 PI16_MOUSE Q148Q6 Q8CHU4 Q9ET66 Q9JJ56 uc008bso.1 uc008bso.2 uc008bso.3 May inhibit cardiomyocyte growth. Interacts with PSP94/MSMB. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ET66-1; Sequence=Displayed; Name=2; IsoId=Q9ET66-2; Sequence=VSP_025575; Expressed strongly in aorta and skin, and weakly in adipose tissue (at protein level). In heart, found in the extracellular space surrounding cardiomyocytes (at protein level). Up-regulated in a mouse model of heart failure. N-glycosylated. Belongs to the CRISP family. Sequence=AAH39124.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH39124.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI18027.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAP45197.1; Type=Erroneous gene model prediction; Evidence=; Sequence=BAB03398.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB03453.1; Type=Erroneous gene model prediction; Evidence=; extracellular region extracellular space negative regulation of peptidase activity peptidase inhibitor activity negative regulation of cell growth involved in cardiac muscle cell development uc008bso.1 uc008bso.2 uc008bso.3 
ENSMUST00000114719.7 Cacnb2 ENSMUST00000114719.7 calcium channel, voltage-dependent, beta 2 subunit, transcript variant 11 (from RefSeq NM_001406097.1) A2ASJ8 CACB2_MOUSE Cacnlb2 ENSMUST00000114719.1 ENSMUST00000114719.2 ENSMUST00000114719.3 ENSMUST00000114719.4 ENSMUST00000114719.5 ENSMUST00000114719.6 NM_001406097 Q8C5J5 Q8CC27 Q9CTQ6 uc008iks.1 uc008iks.2 uc008iks.3 uc008iks.4 Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (PubMed:14674701, PubMed:36424916). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (By similarity). Component of a calcium channel complex consisting of a pore- forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (By similarity). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2 (By similarity). Interacts with CACNA1C (By similarity). Interacts with RRAD; interaction may be involved in beta-adrenergic regulation of heart rate and contractile force (PubMed:36424916). Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane (By similarity). Interacts with TMIGD2 (By similarity). Interacts with CAMK2D (By similarity). Interacts with CBARP (PubMed:24751537). Interacts with CAMK2A (By similarity). Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8CC27-1; Sequence=Displayed; Name=2; IsoId=Q8CC27-2; Sequence=VSP_010730; Name=3; Synonyms=Beta-2g; IsoId=Q8CC27-3; Sequence=VSP_010731; Name=4; IsoId=Q8CC27-4; Sequence=VSP_010731, VSP_010732; Regulated through phosphorylation at Thr-549 by CaMK2D. Belongs to the calcium channel beta subunit family. voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel regulator activity calcium channel activity protein binding plasma membrane voltage-gated calcium channel complex ion transport calcium ion transport chemical synaptic transmission neuromuscular junction development visual perception high voltage-gated calcium channel activity membrane protein kinase binding protein domain specific binding regulation of ion transmembrane transport sarcolemma identical protein binding actin filament binding phosphoprotein binding positive regulation of calcium ion transport calcium ion import calcium ion transmembrane transport protein localization to plasma membrane voltage-gated calcium channel activity involved in cardiac muscle cell action potential membrane depolarization during AV node cell action potential voltage-gated calcium channel activity involved in AV node cell action potential regulation of heart rate by cardiac conduction presynapse membrane depolarization during atrial cardiac muscle cell action potential positive regulation of presynaptic cytosolic calcium concentration voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration regulation of voltage-gated calcium channel activity positive regulation of high voltage-gated calcium channel activity positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel L-type voltage-gated calcium channel complex uc008iks.1 uc008iks.2 uc008iks.3 uc008iks.4 
ENSMUST00000114725.3 Tm9sf5 ENSMUST00000114725.3 transmembrane 9 superfamily member 5 (from RefSeq NM_001128625.2) A2AFI6 A2AFI6_MOUSE ENSMUST00000114725.1 ENSMUST00000114725.2 NM_001128625 Tm9sf5 uc009thm.1 uc009thm.2 uc009thm.3 uc009thm.4 uc009thm.5 uc009thm.6 Membrane ; Multi- pass membrane protein Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. molecular_function membrane integral component of membrane protein localization to membrane uc009thm.1 uc009thm.2 uc009thm.3 uc009thm.4 uc009thm.5 uc009thm.6 
ENSMUST00000114726.8 Rbmx ENSMUST00000114726.8 RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue- specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. (from UniProt Q9WV02) AK135164 ENSMUST00000114726.1 ENSMUST00000114726.2 ENSMUST00000114726.3 ENSMUST00000114726.4 ENSMUST00000114726.5 ENSMUST00000114726.6 ENSMUST00000114726.7 Hnrnpg Hnrpg Q8C2U6 Q9R0Y0 Q9WV02 RBMX_MOUSE Rbmxp1 Rbmxrt uc009thj.1 uc009thj.2 uc009thj.3 uc009thj.4 RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue- specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. Homomultimer. Found in the supraspliceosome complex. Identified in the spliceosome C complex. Interacts with KHDRBS3. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, NCOA5 and PPP1CA Interacts with CLK2, KHDRBS2, SAFB, TRA2B and YTHDC1. Interacts with ERAP1; the interaction is RNA-independent (By similarity). Interacts with SAFB/SAFB1 (PubMed:19403048). Interacts with PPIA/CYPA (By similarity). Nucleus. Note=Localizes in numerous small granules in the nucleus (By similarity). Component of ribonucleosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WV02-1; Sequence=Displayed; Name=2; IsoId=Q9WV02-2; Sequence=VSP_042129; Both isoforms are widely expressed. By high-fructose diet. The RRM domain is necessary for RNA-binding, but not for splice site selection, indicating that its splicing activity does not require direct binding to RNA. O-glycosylated. Arg-182 is dimethylated, probably to asymmetric dimethylarginine. regulation of alternative mRNA splicing, via spliceosome RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleic acid binding chromatin binding RNA binding single-stranded RNA binding mRNA binding nucleus spliceosomal complex nuclear euchromatin transcription from RNA polymerase II promoter mRNA splice site selection mRNA processing membrane protein ectodomain proteolysis RNA splicing protein domain specific binding identical protein binding supraspliceosomal complex positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of mRNA splicing, via spliceosome protein oligomerization extracellular exosome catalytic step 2 spliceosome cellular response to interleukin-1 ribonucleoprotein complex uc009thj.1 uc009thj.2 uc009thj.3 uc009thj.4 
ENSMUST00000114729.8 Dpysl5 ENSMUST00000114729.8 dihydropyrimidinase-like 5, transcript variant 1 (from RefSeq NM_023047.3) Crmp5 DPYL5_MOUSE ENSMUST00000114729.1 ENSMUST00000114729.2 ENSMUST00000114729.3 ENSMUST00000114729.4 ENSMUST00000114729.5 ENSMUST00000114729.6 ENSMUST00000114729.7 NM_023047 Q9EQF6 uc008wvw.1 uc008wvw.2 uc008wvw.3 Involved in the negative regulation of dendrite outgrowth. Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4. Interacts with SEPTIN4 isoform 4. Interacts with MAP2 and TUBB3 (By similarity). Cytoplasm Note=Translocates into the mitochondria upon interaction with SEPTIN4 isoform 4. Detected in brain. Detected in whole embryos after 11 days of development. Detected in embryonic head. Highly expressed in newborns and up to 7 days after birth. Expression is decreased after 14 days. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure. protein binding cytoplasm cytosol nervous system development axon guidance microtubule binding hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides dendrite macromolecular complex neuronal cell body dihydropyrimidinase activity pyrimidine nucleobase catabolic process uc008wvw.1 uc008wvw.2 uc008wvw.3 
ENSMUST00000114732.3 Ephb6 ENSMUST00000114732.3 Eph receptor B6, transcript variant 3 (from RefSeq NR_166495.1) Cekl ENSMUST00000114732.1 ENSMUST00000114732.2 EPHB6_MOUSE NR_166495 O08644 Q3TQ77 Q8BN76 Q8K0A9 uc009bqb.1 uc009bqb.2 uc009bqb.3 uc009bqb.4 Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity). Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner (By similarity). [Isoform 1]: Cell membrane; Single-pass type I membrane protein. [Isoform 2]: Secreted. [Isoform 3]: Secreted. Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=O08644-1; Sequence=Displayed; Name=2; IsoId=O08644-2; Sequence=VSP_003020, VSP_003021; Name=3; IsoId=O08644-3; Sequence=VSP_003022, VSP_003023; High level in thymus, and brain. Very low levels of expression in kidney, lung, liver, bone marrow, skeletal muscle, spleen from 2 week old and adult mice, heart, testes and embryonic stem cells. The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2 (By similarity). Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand- independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion (By similarity). Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. nucleotide binding type IV hypersensitivity T cell mediated immunity protein kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity ATP binding extracellular region plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway cell surface membrane integral component of membrane peptidyl-tyrosine phosphorylation positive regulation of protein binding receptor complex ephrin receptor signaling pathway cytokine secretion activated T cell proliferation positive regulation of T cell costimulation uc009bqb.1 uc009bqb.2 uc009bqb.3 uc009bqb.4 
ENSMUST00000114740.3 Cfap91 ENSMUST00000114740.3 Involved in sperm flagellum axonemal organization and function (By similarity). May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity). (from UniProt Q8BRC6) AK045121 Aat1 CFA91_MOUSE Cfap91 E9PZ32 E9QND1 ENSMUST00000114740.1 ENSMUST00000114740.2 Maats1 Q8BRC6 Spata26 uc289epd.1 uc289epd.2 Involved in sperm flagellum axonemal organization and function (By similarity). May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity). Part of a complex containing MYCBP, AKAP1 and PRKAR2B. Cytoplasm Mitochondrion Cytoplasm, cytoskeleton, cilium axoneme Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BRC6-2; Sequence=Displayed; Name=2; IsoId=Q8BRC6-1; Sequence=VSP_045751, VSP_045752; Expressed in the testis, in cells involved in spermatogenesis. Expression begins in 1 week old mice. Phosphorylated by PKA. Belongs to the CFAP91 family. cilium movement molecular_function cellular_component cytoplasm mitochondrion cytoskeleton axoneme biological_process motile cilium cell projection radial spoke stalk uc289epd.1 uc289epd.2 
ENSMUST00000114741.4 Pstpip2 ENSMUST00000114741.4 proline-serine-threonine phosphatase-interacting protein 2 (from RefSeq NM_013831.4) ENSMUST00000114741.1 ENSMUST00000114741.2 ENSMUST00000114741.3 Mayp NM_013831 PPIP2_MOUSE Q6GTF6 Q99M15 Q9Z189 uc008fry.1 uc008fry.2 uc008fry.3 uc008fry.4 Binds to F-actin. May be involved in regulation of the actin cytoskeleton. Q99M15; Q61152: Ptpn18; NbExp=7; IntAct=EBI-8653964, EBI-7074223; Cytoplasm. Membrane; Peripheral membrane protein. Expressed in macrophage-containing tissues, including bone marrow, spleen, liver, kidney, intestine and brain. Phosphorylated on tyrosine. actin binding protein binding cytoplasm cytosol cytoskeleton plasma membrane cytoskeleton organization cytoskeletal protein binding membrane cell migration uc008fry.1 uc008fry.2 uc008fry.3 uc008fry.4 
ENSMUST00000114753.8 Hacd1 ENSMUST00000114753.8 3-hydroxyacyl-CoA dehydratase 1, transcript variant 1 (from RefSeq NM_013935.3) B9EHK9 B9EHK9_MOUSE ENSMUST00000114753.1 ENSMUST00000114753.2 ENSMUST00000114753.3 ENSMUST00000114753.4 ENSMUST00000114753.5 ENSMUST00000114753.6 ENSMUST00000114753.7 Hacd1 NM_013935 Ptpla uc008ikd.1 uc008ikd.2 uc008ikd.3 Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Reaction=(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O; Xref=Rhea:RHEA:39159, ChEBI:CHEBI:15377, ChEBI:CHEBI:61526, ChEBI:CHEBI:74278; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39160; Evidence=; Reaction=a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O; Xref=Rhea:RHEA:45812, ChEBI:CHEBI:15377, ChEBI:CHEBI:83728, ChEBI:CHEBI:85440; EC=4.2.1.134; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45813; Evidence=; Lipid metabolism; fatty acid biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the very long-chain fatty acids dehydratase HACD family. Lacks conserved residue(s) required for the propagation of feature annotation. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process membrane integral component of membrane lyase activity 3-hydroxy-behenoyl-CoA dehydratase activity 3-hydroxy-lignoceroyl-CoA dehydratase activity uc008ikd.1 uc008ikd.2 uc008ikd.3 
ENSMUST00000114763.3 Fstl1 ENSMUST00000114763.3 follistatin-like 1 (from RefSeq NM_008047.5) ENSMUST00000114763.1 ENSMUST00000114763.2 FSTL1_MOUSE Frp Fstl NM_008047 Q62356 Q6GTX2 Q99JI9 Tsc36 uc007zej.1 uc007zej.2 uc007zej.3 Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (PubMed:21826198, PubMed:19595790). Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (PubMed:20054002). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity). Homodimer (PubMed:31351024). Interacts with SCN10A (By similarity). Interacts with DIP2A; DIP2A may act as a cell surface receptor for FSTL1 (PubMed:20054002). Interacts with BMP4 (By similarity). Interacts with CD14; this interaction promotes TL4- mediated signaling cascade (By similarity). Q62356; Q14689: DIP2A; Xeno; NbExp=3; IntAct=EBI-2564326, EBI-2564275; Secreted During central nervous system development, strongly expressed in the telencephalon, diencephalon, brainstem, limbic system and spinal cord (PubMed:19595790). Widely expressed in all organs (PubMed:21826198). Deletion mice die at birth from respiratory distress and show multiple defects in lung development. In addition, skeletal development is strongly impaired. calcium ion binding protein binding extracellular region extracellular space multicellular organism development heparin binding cell differentiation regulation of BMP signaling pathway response to starvation uc007zej.1 uc007zej.2 uc007zej.3 
ENSMUST00000114764.8 Slc26a8 ENSMUST00000114764.8 solute carrier family 26, member 8, transcript variant 1 (from RefSeq NM_001290320.2) ENSMUST00000114764.1 ENSMUST00000114764.2 ENSMUST00000114764.3 ENSMUST00000114764.4 ENSMUST00000114764.5 ENSMUST00000114764.6 ENSMUST00000114764.7 NM_001290320 Q8R0C3 S26A8_MOUSE Slc26a8 Tat1 uc056zdz.1 uc056zdz.2 uc056zdz.3 Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane. Stimulates anion transport activity of CFTR (By similarity). May cooperate with CFTR in the regulation of chloride and bicarbonate ions fluxes required for activation of the ADCY10/PKA pathway during sperm motility and sperm capacitation (PubMed:22121115). May play a role in sperm tail differentiation and motility and hence male fertility (PubMed:17517695). Reaction=chloride(in) + sulfate(out) = chloride(out) + sulfate(in); Xref=Rhea:RHEA:75295, ChEBI:CHEBI:16189, ChEBI:CHEBI:17996; Evidence=; Reaction=chloride(out) + oxalate(in) = chloride(in) + oxalate(out); Xref=Rhea:RHEA:72263, ChEBI:CHEBI:17996, ChEBI:CHEBI:30623; Evidence=; Interacts with RACGAP1. Interacts with CFTR; stimulates anion transport activity of CFTR. Membrane ; Multi- pass membrane protein Note=Located at the annulus ring structure within the sperm cell. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R0C3-1; Sequence=Displayed; Name=2 ; IsoId=Q8R0C3-2; Sequence=VSP_052702, VSP_052703; Expressed in testis and epididymis. Located at the end of the midpiece of the flagella, known as the annulus, in spermatozoa. N-glycosylated. Homozygous knockout mice lacking Tat1 are viable and indistinguishable from their wild-type littermates in survival rate, general appearance, and gross behavior (i.e. size, weight, fur, and activity) (PubMed:17517695). However, over a period of two months, males becames infertile despite normal sexual behavior (PubMed:17517695). Sperm lacks motility and displayed a capacitation defect (PubMed:17517695). Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. chloride channel activity plasma membrane integral component of plasma membrane ion transport anion transport chloride transport multicellular organism development spermatogenesis secondary active sulfate transmembrane transporter activity sulfate transport anion transmembrane transporter activity bicarbonate transmembrane transporter activity chloride transmembrane transporter activity sulfate transmembrane transporter activity anion:anion antiporter activity bicarbonate transport membrane integral component of membrane oxalate transmembrane transporter activity oxalate transport cell differentiation flagellated sperm motility sperm capacitation meiotic cell cycle transmembrane transport anion transmembrane transport sulfate transmembrane transport chloride transmembrane transport uc056zdz.1 uc056zdz.2 uc056zdz.3 
ENSMUST00000114765.4 Tmem182 ENSMUST00000114765.4 transmembrane protein 182 (from RefSeq NM_001081198.1) B2RVY9 ENSMUST00000114765.1 ENSMUST00000114765.2 ENSMUST00000114765.3 NM_001081198 TM182_MOUSE uc007auq.1 uc007auq.2 uc007auq.3 Negatively regulates myogenesis and skeletal muscle regeneration via its association with ITGB1 (PubMed:34427057). Modulates ITGB1 activation by decreasing ITGB1-LAMB1 interaction and inhibiting ITGB1-mediated intracellular signaling during myogenesis (PubMed:34427057). Interacts with ITGB1. Cell membrane ; Multi-pass membrane protein Highly expressed in white adipose tissues (WAT), with 10-fold to 20-fold higher levels than in brown adipose tissue (BAT). Also expressed in skeletal muscle, heart and lung. Lower relative levels of expression in kidney, spleen, testis, brain and liver. Up-regulated in adipogenesis and also markedly up- regulated during in vitro myogenesis of C2C12 myoblasts to myocytes. Up-regulated during myoblast differentiation. Mice exhibit significant increases in body weight, muscle mass, muscle fiber number, muscle fiber diameter and myotube formation and an acceleration of skeletal muscle regeneration. Belongs to the TMEM182 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007auq.1 uc007auq.2 uc007auq.3 
ENSMUST00000114766.8 Map7d3 ENSMUST00000114766.8 MAP7 domain containing 3 (from RefSeq NM_177293.3) A2AEY4 ENSMUST00000114766.1 ENSMUST00000114766.2 ENSMUST00000114766.3 ENSMUST00000114766.4 ENSMUST00000114766.5 ENSMUST00000114766.6 ENSMUST00000114766.7 MA7D3_MOUSE Mdp3 Mtap7d3 NM_177293 Q0VF65 Q8C7V9 Q8C857 Q8CDD4 uc009tgp.1 uc009tgp.2 uc009tgp.3 Promotes the assembly and stability of microtubules. Cytoplasm, cytoskeleton, spindle Note=Localizes to the microtubules throughout mitosis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AEY4-1; Sequence=Displayed; Name=2; IsoId=A2AEY4-2; Sequence=VSP_028500; High expression in lung, skeletal muscle, brain, and kidney, with much weaker expression in spleen, small intestine, liver, and heart. Belongs to the MAP7 family. Sequence=AAI18964.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC26846.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC33317.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAM26746.1; Type=Erroneous gene model prediction; Evidence=; microtubule cytoskeleton organization cytoplasm spindle cytoskeleton microtubule binding microtubule cytoskeleton tubulin binding microtubule polymerization uc009tgp.1 uc009tgp.2 uc009tgp.3 
ENSMUST00000114772.9 Fhl1 ENSMUST00000114772.9 four and a half LIM domains 1, transcript variant 2 (from RefSeq NM_001077362.3) A2AEX8 A2AEX8_MOUSE ENSMUST00000114772.1 ENSMUST00000114772.2 ENSMUST00000114772.3 ENSMUST00000114772.4 ENSMUST00000114772.5 ENSMUST00000114772.6 ENSMUST00000114772.7 ENSMUST00000114772.8 Fhl1 NM_001077362 uc009tgo.1 uc009tgo.2 uc009tgo.3 uc009tgo.4 metal ion binding uc009tgo.1 uc009tgo.2 uc009tgo.3 uc009tgo.4 
ENSMUST00000114777.10 Pias2 ENSMUST00000114777.10 protein inhibitor of activated STAT 2, transcript variant 1 (from RefSeq NM_008602.4) ENSMUST00000114777.1 ENSMUST00000114777.2 ENSMUST00000114777.3 ENSMUST00000114777.4 ENSMUST00000114777.5 ENSMUST00000114777.6 ENSMUST00000114777.7 ENSMUST00000114777.8 ENSMUST00000114777.9 Miz1 NM_008602 O54987 PIAS2_MOUSE Piasx Q8C384 Q8C5D8 Q8CDQ8 Q8K208 Q99JX5 Q9D5W7 Q9QZ63 uc008frc.1 uc008frc.2 uc008frc.3 uc008frc.4 Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIASx-beta, but not isoform PIASx-alpha, promotes MDM2 sumoylation. Isoform PIASx-alpha promotes PARK7 sumoylation. Isoform PIASx-beta promotes NCOA2 sumoylation more efficiently than isoform PIASx-alpha (By similarity). Sumoylates PML at'Lys-65' and 'Lys-160' (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein sumoylation. Binds SUMO1 and UBE2I. Interacts with AXIN1, JUN, MDM2, PARK7, TP53 and TP73 isoform alpha, but not TP73 isoform beta. Interacts with STAT4 following IL12 and IFN-alpha stimulation of T-cells. Interacts also with GTF2I, GTF2IRD1, IKFZ1, DAB2 and MSX2, as well as with several steroid receptors, including ESR1, ESR2, NR3C1, PGR, AR, and with NCOA2. Sumoylation of a target protein seems to enhance the interaction. Binds to sumoylated ELK1. Interacts with PLAG1 (By similarity). Binds DNA, such as CDKN1A promoter, in a sequence-specific manner. Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase (By similarity). Interacts with IFIH1/MDA5 (By similarity). Interacts with PML (By similarity). Interacts with PRDM1 (By similarity). Q8C5D8; P98078: Dab2; NbExp=2; IntAct=EBI-6305825, EBI-1391846; Q8C5D8; P98078-3: Dab2; NbExp=3; IntAct=EBI-6305825, EBI-6305891; Q8C5D8-1; P08152: Egr2; NbExp=5; IntAct=EBI-8064899, EBI-7070449; Nucleus speckle Nucleus, PML body Nucleus Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (By similarity). Colocalizes with SUMO1 in nuclear granules (PubMed:12077349). Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=PIASx-beta, Miz1; IsoId=Q8C5D8-1; Sequence=Displayed; Name=2; Synonyms=PIASx-alpha, ARIP3; IsoId=Q8C5D8-2; Sequence=VSP_012199, VSP_012201; Name=3; IsoId=Q8C5D8-3; Sequence=VSP_012198, VSP_012199, VSP_012201; Name=4; IsoId=Q8C5D8-4; Sequence=VSP_012200, VSP_012202; Name=5; IsoId=Q8C5D8-5; Sequence=VSP_012198; The LXXLL motif is a transcriptional coregulator signature. Sumoylated. Belongs to the PIAS family. Sequence=AAB96678.1; Type=Erroneous initiation; Evidence=; Sequence=BAB29594.1; Type=Frameshift; Evidence=; RNA polymerase II transcription factor binding DNA binding transcription cofactor activity protein binding nucleus nucleoplasm transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription factor binding zinc ion binding nuclear body PML body nuclear speck transferase activity protein sumoylation SUMO transferase activity protein domain specific binding estrogen receptor binding androgen receptor signaling pathway ubiquitin protein ligase binding glucocorticoid receptor binding negative regulation of sequence-specific DNA binding transcription factor activity regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding androgen receptor binding positive regulation of dendrite morphogenesis regulation of androgen receptor signaling pathway negative regulation of androgen receptor signaling pathway SUMO ligase activity uc008frc.1 uc008frc.2 uc008frc.3 uc008frc.4 
ENSMUST00000114779.9 Ssbp1 ENSMUST00000114779.9 single-stranded DNA binding protein 1, transcript variant 1 (from RefSeq NM_212468.3) ENSMUST00000114779.1 ENSMUST00000114779.2 ENSMUST00000114779.3 ENSMUST00000114779.4 ENSMUST00000114779.5 ENSMUST00000114779.6 ENSMUST00000114779.7 ENSMUST00000114779.8 NM_212468 Q8R2K3 Q8R2K3_MOUSE Ssbp1 uc009bms.1 uc009bms.2 uc009bms.3 Mitochondrion matrix, mitochondrion nucleoid DNA binding single-stranded DNA binding DNA replication uc009bms.1 uc009bms.2 uc009bms.3 
ENSMUST00000114787.8 Stxbp5l ENSMUST00000114787.8 syntaxin binding protein 5-like, transcript variant xb (from RefSeq NM_172440.3) ENSMUST00000114787.1 ENSMUST00000114787.2 ENSMUST00000114787.3 ENSMUST00000114787.4 ENSMUST00000114787.5 ENSMUST00000114787.6 ENSMUST00000114787.7 Llgl4 NM_172440 Q3TSM3 Q3UVG2 Q5DQR1 Q5DQR2 Q5DQR3 Q5DQR4 Q8BS52 STB5L_MOUSE uc007zds.1 uc007zds.2 uc007zds.3 uc007zds.4 uc007zds.5 Plays a role in vesicle trafficking and exocytosis inhibition (PubMed:25002582). In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane (PubMed:21998599). Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (PubMed:24744148). Promotes as well axonal outgrowth (By similarity). Interacts with STX1A and STX4. Cytoplasm Cell membrane ; Peripheral membrane protein Membrane ; Peripheral membrane protein Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=Tomosyn-2 isoform xb; IsoId=Q5DQR4-1; Sequence=Displayed; Name=2; Synonyms=Tomosyn-2 isoform m; IsoId=Q5DQR4-2; Sequence=VSP_016296; Name=3; Synonyms=Tomosyn-2 isoform b; IsoId=Q5DQR4-3; Sequence=VSP_016295; Name=4; Synonyms=Tomosyn-2 isoform s; IsoId=Q5DQR4-4; Sequence=VSP_016295, VSP_016296; Name=5; IsoId=Q5DQR4-5; Sequence=VSP_016295, VSP_016297, VSP_016298; Name=6; IsoId=Q5DQR4-6; Sequence=VSP_016299; Name=7; IsoId=Q5DQR4-7; Sequence=VSP_016300; Detected in hippocampus and cerebellum (PubMed:15659226). Expressed in pancreatic beta-cells where it modulates insulin secretion (PubMed:21998599). Phosphorylated, leading to STXBP5L increased turnover and subsequent de-repression of insulin secretion (PubMed:25002582). Phosphorylated on serine residues in response to glucose or phorbol esters (PubMed:25002582). Ubiquitinated by the E3 ligase SYVN1, leading to STXBP5L proteasomal degradation. Mutant mice are born at the expected Mendelian rate and show normal body weight development. However, they display reduced sensorimotor gating and impaired motor performance. Belongs to the WD repeat L(2)GL family. GTPase activator activity cytoplasm plasma membrane exocytosis protein transport membrane integral component of membrane vesicle-mediated transport Rab GTPase binding regulation of exocytosis syntaxin binding SNARE complex neuromuscular junction glucose homeostasis positive regulation of GTPase activity myosin II binding negative regulation of insulin secretion positive regulation of protein secretion neuronal dense core vesicle regulation of synaptic vesicle exocytosis uc007zds.1 uc007zds.2 uc007zds.3 uc007zds.4 uc007zds.5 
ENSMUST00000114792.8 Fkbp5 ENSMUST00000114792.8 Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production. (from UniProt Q64378) AK159389 ENSMUST00000114792.1 ENSMUST00000114792.2 ENSMUST00000114792.3 ENSMUST00000114792.4 ENSMUST00000114792.5 ENSMUST00000114792.6 ENSMUST00000114792.7 FKBP5_MOUSE Fkbp51 Q64378 uc008bra.1 uc008bra.2 uc008bra.3 uc008bra.4 uc008bra.5 Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Inhibited by both FK506 and rapamycin. Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors (PubMed:11751894). Upon ligand binding dissociates from the complex and FKBP4 takes its place (PubMed:11751894). Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP (By similarity). Interacts with NR3C1 (PubMed:21994940). Interacts with Akt/AKT1 and PHLPP1; enhancing dephosphorylation and subsequent activation of Akt/AKT1 (By similarity). Interacts with IFI44L; this interaction modulates the kinase activity of IKBKB and IKBKE (By similarity). Interacts with IKBKB and IKBKE (By similarity). Q64378; P06537: Nr3c1; NbExp=2; IntAct=EBI-492796, EBI-492753; Cytoplasm Nucleus Widely expressed, highest levels found in the liver, skeletal muscle, kidney and thymus. Expression is regulated during adipocyte differentiation. Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1. Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation. protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity protein binding FK506 binding nucleus nucleoplasm cytoplasm cytosol response to bacterium isomerase activity heat shock protein binding chaperone-mediated protein folding uc008bra.1 uc008bra.2 uc008bra.3 uc008bra.4 uc008bra.5 
ENSMUST00000114799.8 Tead3 ENSMUST00000114799.8 TEA domain family member 3, transcript variant 1 (from RefSeq NM_001098226.3) ENSMUST00000114799.1 ENSMUST00000114799.2 ENSMUST00000114799.3 ENSMUST00000114799.4 ENSMUST00000114799.5 ENSMUST00000114799.6 ENSMUST00000114799.7 F8VPU0 F8VPU0_MOUSE NM_001098226 Tead3 uc008bqs.1 uc008bqs.2 uc008bqs.3 uc008bqs.4 uc008bqs.5 This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and thought to play a role in placental gene regulation and development. Alternative splicing, and alternate use of an upstream AUG translation initiation codon, and an in-frame downstream non-AUG (AUA) codon, results in 2 isoforms. [provided by RefSeq, Jul 2008]. Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated hippo signaling positive regulation of transcription from RNA polymerase II promoter uc008bqs.1 uc008bqs.2 uc008bqs.3 uc008bqs.4 uc008bqs.5 
ENSMUST00000114803.9 Fance ENSMUST00000114803.9 Fanconi anemia, complementation group E, transcript variant 1 (from RefSeq NM_001163819.1) B8JJD3 B8JJD3_MOUSE ENSMUST00000114803.1 ENSMUST00000114803.2 ENSMUST00000114803.3 ENSMUST00000114803.4 ENSMUST00000114803.5 ENSMUST00000114803.6 ENSMUST00000114803.7 ENSMUST00000114803.8 Fance NM_001163819 uc289ixs.1 uc289ixs.2 This gene encodes the complementation group E subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes: FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The FA complex is necessary for protection against DNA damage. This gene product is required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Defects in the related human gene are a cause of Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Translation of this protein is initiated at a non-AUG (CUG) start codon, which is inferred from the related human gene and the notion that this protein is functionally indispensable. Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2009]. molecular_function biological_process interstrand cross-link repair Fanconi anaemia nuclear complex uc289ixs.1 uc289ixs.2 
ENSMUST00000114810.2 Xlr ENSMUST00000114810.2 X-linked lymphocyte-regulated, transcript variant 7 (from RefSeq NM_001426073.1) ENSMUST00000114810.1 NM_001426073 Q544L6 Q544L6_MOUSE Xlr uc009tfm.1 uc009tfm.2 uc009tfm.3 uc009tfm.4 uc009tfm.5 Belongs to the XLR/SYCP3 family. uc009tfm.1 uc009tfm.2 uc009tfm.3 uc009tfm.4 uc009tfm.5 
ENSMUST00000114812.9 Golgb1 ENSMUST00000114812.9 Golgb1 (from geneSymbol) BC150731 E9QAH1 E9QAH1_MOUSE ENSMUST00000114812.1 ENSMUST00000114812.2 ENSMUST00000114812.3 ENSMUST00000114812.4 ENSMUST00000114812.5 ENSMUST00000114812.6 ENSMUST00000114812.7 ENSMUST00000114812.8 Golgb1 uc007zdd.1 uc007zdd.2 uc007zdd.3 endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cis-Golgi network membrane integral component of membrane uc007zdd.1 uc007zdd.2 uc007zdd.3 
ENSMUST00000114816.8 C1qtnf5 ENSMUST00000114816.8 C1q and tumor necrosis factor related protein 5, transcript variant 3 (from RefSeq NM_001040631.2) C1QT5_MOUSE Ctrp5 ENSMUST00000114816.1 ENSMUST00000114816.2 ENSMUST00000114816.3 ENSMUST00000114816.4 ENSMUST00000114816.5 ENSMUST00000114816.6 ENSMUST00000114816.7 NM_001040631 Q8K479 uc009pbt.1 uc009pbt.2 uc009pbt.3 The protein encoded by this gene is a member of the C1q/tumor necrosis factor superfamily. This family member is a secretory protein that functions in eye development. Mutations in this gene are thought to underlie the pathophysiology of late-onset retinal degeneration (L-ORD) and early-onset long anterior zonules (LAZ). Bicistronic transcripts composed of the coding sequences for this gene (C1qtnf5) and the membrane-type frizzled-related protein gene (Mfrp) have been identified, and the resulting products can interact with each other. Co-transcription of C1qtnf5 and Mfrp has been observed in both human and mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]. Homotrimer (via collagen-like domain). May form higher order oligomers by supercoiling of the trimers (By similarity). May interact with ERFE. Q8K479; Q8K480: Mfrp; NbExp=5; IntAct=EBI-29374993, EBI-29374967; Q8K479; Q9BY79: MFRP; Xeno; NbExp=6; IntAct=EBI-29374993, EBI-29375513; Secreted extracellular region collagen trimer extracellular space plasma membrane bicellular tight junction protein secretion membrane apical plasma membrane lateral plasma membrane transport vesicle macromolecular complex identical protein binding cell projection inner ear development uc009pbt.1 uc009pbt.2 uc009pbt.3 
ENSMUST00000114823.8 Mkrn1 ENSMUST00000114823.8 makorin, ring finger protein, 1, transcript variant 8 (from RefSeq NM_001411240.1) E9QAG7 E9QAG7_MOUSE ENSMUST00000114823.1 ENSMUST00000114823.2 ENSMUST00000114823.3 ENSMUST00000114823.4 ENSMUST00000114823.5 ENSMUST00000114823.6 ENSMUST00000114823.7 Mkrn1 NM_001411240 uc009blq.1 uc009blq.2 uc009blq.3 uc009blq.4 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. metal ion binding uc009blq.1 uc009blq.2 uc009blq.3 uc009blq.4 
ENSMUST00000114829.9 Eaf2 ENSMUST00000114829.9 ELL associated factor 2, transcript variant 2 (from RefSeq NM_001113401.1) EAF2_MOUSE ENSMUST00000114829.1 ENSMUST00000114829.2 ENSMUST00000114829.3 ENSMUST00000114829.4 ENSMUST00000114829.5 ENSMUST00000114829.6 ENSMUST00000114829.7 ENSMUST00000114829.8 Festa NM_001113401 Q7TN80 Q91ZD6 Q99KD2 Traits uc007zcx.1 uc007zcx.2 uc007zcx.3 Acts as a transcriptional transactivator of ELL and ELL2 elongation activities (By similarity). Acts as a transcriptional transactivator of TCEA1 elongation activity. Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with ELL and ELL2 (By similarity). Isoform 1 and isoform 2 interact with TCEA1. Nucleus speckle Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=FESTA-L; IsoId=Q91ZD6-1; Sequence=Displayed; Name=2; Synonyms=FESTA-S; IsoId=Q91ZD6-2; Sequence=VSP_015311; Isoform 1 is expressed in ovary, uterus, mammary glands, brain, spleen, liver, lung, thymus, kidney, skeletal muscle, skin and testis. Isoform 2 is expressed in kidney. Expressed in brain and spinal cord at 10 dpc. Expressed in brain, spinal cord, cranial and spinal ganglia, lens, retina, cochlea, olfactory epithelium and pituitary at 12 dpc. Expressed in intestine, bladder endothelium, retinal ganglion cells, nephrons, bronchial epithelium, secretory epithelium of submandibular glands, tubular epithelium of the epididymis, ectodermal invaginations of mammary buds and vibrissae follicles, incisors and molars at 15 dpc. Belongs to the EAF family. Sequence=AAH04721.1; Type=Erroneous initiation; Evidence=; Sequence=BAC77525.1; Type=Erroneous initiation; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated transcription elongation factor complex nuclear speck negative regulation of cell growth ELL-EAF complex positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of epithelial cell proliferation involved in prostate gland development intrinsic apoptotic signaling pathway uc007zcx.1 uc007zcx.2 uc007zcx.3 
ENSMUST00000114831.9 Il15ra ENSMUST00000114831.9 interleukin 15 receptor, alpha chain, transcript variant 5 (from RefSeq NM_001271499.2) A2AP35 A2AP36 A2AP37 ENSMUST00000114831.1 ENSMUST00000114831.2 ENSMUST00000114831.3 ENSMUST00000114831.4 ENSMUST00000114831.5 ENSMUST00000114831.6 ENSMUST00000114831.7 ENSMUST00000114831.8 I15RA_MOUSE NM_001271499 Q60819 Q80Z90 Q80Z91 Q80Z92 Q8R5E4 uc008iiy.1 uc008iiy.2 uc008iiy.3 uc008iiy.4 High-affinity receptor for interleukin-15 (PubMed:17947230). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (PubMed:17947230). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (By similarity). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (By similarity). The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (By similarity). Interacts with SYK (By similarity). Membrane ; Single- pass type I membrane protein Nucleus membrane ; Single-pass type I membrane protein Cell surface [Soluble interleukin-15 receptor subunit alpha]: Secreted, extracellular space Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q60819-1; Sequence=Displayed; Name=2; Synonyms=1A; IsoId=Q60819-2; Sequence=VSP_012629, VSP_012630; Name=3; Synonyms=1B, IL-15R-alphadelta4; IsoId=Q60819-3; Sequence=VSP_012629, VSP_012630, VSP_012631; Name=4; Synonyms=1C, IL-15R-alphadelta34; IsoId=Q60819-4; Sequence=VSP_012628, VSP_012629, VSP_012630, VSP_012631, VSP_012632; Name=5; Synonyms=2, 2A; IsoId=Q60819-5; Sequence=VSP_012627, VSP_012628, VSP_012629; Name=6; Synonyms=IL-15R-alphadelta345; IsoId=Q60819-6; Sequence=VSP_012628, VSP_012629, VSP_012630, VSP_012631, VSP_012633; Widely expressed. N-glycosylated and O-glycosylated. A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor (By similarity). It also binds IL15 and thus interferes with IL15 binding to the membrane receptor (By similarity). It was shown that proteolytic cleavage of Il15ra involves ADAM17/TACE; this publication has later been retracted. extracellular region extracellular space nucleus plasma membrane JAK-STAT cascade cell surface negative regulation of neuron projection development membrane integral component of membrane protein kinase binding cytoplasmic vesicle nuclear membrane positive regulation of natural killer cell differentiation interleukin-15-mediated signaling pathway interleukin-15 receptor activity positive regulation of phagocytosis uc008iiy.1 uc008iiy.2 uc008iiy.3 uc008iiy.4 
ENSMUST00000114835.8 Pabir3 ENSMUST00000114835.8 PABIR family member 3, transcript variant 1 (from RefSeq NM_028671.3) ENSMUST00000114835.1 ENSMUST00000114835.2 ENSMUST00000114835.3 ENSMUST00000114835.4 ENSMUST00000114835.5 ENSMUST00000114835.6 ENSMUST00000114835.7 Fam122c NM_028671 Pabir3 Q9D5J5 Q9D5J5_MOUSE uc009tez.1 uc009tez.2 uc009tez.3 Belongs to the FAM122 family. molecular_function cellular_component biological_process uc009tez.1 uc009tez.2 uc009tez.3 
ENSMUST00000114839.8 Dnajb6 ENSMUST00000114839.8 DnaJ heat shock protein family (Hsp40) member B6, transcript variant 3 (from RefSeq NM_011847.4) DNJB6_MOUSE ENSMUST00000114839.1 ENSMUST00000114839.2 ENSMUST00000114839.3 ENSMUST00000114839.4 ENSMUST00000114839.5 ENSMUST00000114839.6 ENSMUST00000114839.7 Hsj2 Mrj NM_011847 O54946 Q3TE94 Q3U6L0 Q3UNJ5 Q3UYT7 Q99LA5 Q9QYI9 uc008wup.1 uc008wup.2 uc008wup.3 uc008wup.4 Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co- chaperone of HSP70 (PubMed:18373498). Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase- 3 activity (By similarity). Homooligomer. Interacts with BAG3, HSPB8 and STUB1 (By similarity). Interacts with ALKBH1 (PubMed:18163532). Interacts with HSP70, KRT18 and PTTG (By similarity). Interacts with Slfn1; promoting nuclear translocation of Slfn1 (PubMed:18373498). O54946; Q8BWG8: Arrb1; NbExp=6; IntAct=EBI-642500, EBI-641778; O54946-2; P0CB42: Alkbh1; NbExp=2; IntAct=EBI-13941040, EBI-13941048; O54946-2; P56524: HDAC4; Xeno; NbExp=2; IntAct=EBI-13941040, EBI-308629; Cytoplasm, perinuclear region Nucleus Cytoplasm, myofibril, sarcomere, Z line Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=O54946-1; Sequence=Displayed; Name=B; IsoId=O54946-2; Sequence=VSP_026212, VSP_026213; ATPase activator activity DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol protein folding Z disc actin cytoskeleton organization extracellular matrix organization heat shock protein binding positive regulation of ATPase activity regulation of protein localization protein localization to nucleus identical protein binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein binding involved in protein folding intermediate filament organization negative regulation of transcription, DNA-templated perinuclear region of cytoplasm unfolded protein binding chaperone binding chorio-allantoic fusion syncytiotrophoblast cell differentiation involved in labyrinthine layer development chorion development chaperone-mediated protein folding negative regulation of inclusion body assembly uc008wup.1 uc008wup.2 uc008wup.3 uc008wup.4 
ENSMUST00000114840.2 Thy1 ENSMUST00000114840.2 thymus cell antigen 1, theta (from RefSeq NM_009382.3) ENSMUST00000114840.1 NM_009382 P01831 THY1_MOUSE Thy-1 uc009pbl.1 uc009pbl.2 This gene encodes a glycoprotein that is anchored to the cell surface of thymocytes, neuronal and other cells through a glycosyl-phosphatidylinositol moiety. A soluble form of the encoded protein has also been detected in serum and cerebrospinal fluid. The encoded protein undergoes further processing to generate the mature protein which mediates cell-cell interactions to trigger downstream signaling pathways. [provided by RefSeq, Jul 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ887914.1, BQ951564.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. Cell membrane; Lipid-anchor, GPI-anchor. There are two major alleles; Thy-1.1 (CD90.1) and Thy-1.2 (CD90.2). angiogenesis regulation of cell-matrix adhesion positive regulation of cellular extravasation GTPase activator activity integrin binding endoplasmic reticulum cytosol plasma membrane negative regulation of protein kinase activity cytoskeleton organization cell adhesion integrin-mediated signaling pathway cell-cell signaling external side of plasma membrane cell surface membrane apical plasma membrane enzyme binding protein kinase binding regulation of cell migration negative regulation of cell migration dendrite growth cone axolemma anchored component of membrane anchored component of external side of plasma membrane dendrite membrane neuronal cell body membrane positive regulation of heterotypic cell-cell adhesion GPI anchor binding receptor clustering myelin sheath positive regulation of GTPase activity membrane raft retinal cone cell development anchored component of plasma membrane protein autophosphorylation focal adhesion assembly negative regulation of axonogenesis T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway positive regulation of T cell activation positive regulation of release of sequestered calcium ion into cytosol positive regulation of focal adhesion assembly negative regulation of protein tyrosine kinase activity negative regulation of neuron projection regeneration cell-cell adhesion regulation of Rho-dependent protein serine/threonine kinase activity uc009pbl.1 uc009pbl.2 
ENSMUST00000114842.9 Anks1 ENSMUST00000114842.9 ankyrin repeat and SAM domain containing 1, transcript variant 3 (from RefSeq NM_181413.4) ANS1A_MOUSE Anks1a ENSMUST00000114842.1 ENSMUST00000114842.2 ENSMUST00000114842.3 ENSMUST00000114842.4 ENSMUST00000114842.5 ENSMUST00000114842.6 ENSMUST00000114842.7 ENSMUST00000114842.8 Kiaa0229 NM_181413 Odin P59672 Q6ZQG0 uc008bpx.1 uc008bpx.2 uc008bpx.3 uc008bpx.4 Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction. Interacts (via SAM domain) with EPHA2 (via SAM domain) (By similarity). Interacts with EPHA8; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination (PubMed:17875921). Interacts (via SAM domain) with EPHA6 (via SAM domain) (PubMed:29749928). Cytoplasm Cell projection Note=Cytoplasmic before and after growth factor treatment. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P59672-1; Sequence=Displayed; Name=2; IsoId=P59672-2; Sequence=VSP_012704, VSP_012705, VSP_012706; Phosphorylated on tyrosine residues in response to EGF and PDGF. Sequence=BAC97904.1; Type=Erroneous initiation; Evidence=; nucleoplasm cytoplasm cytosol substrate-dependent cell migration neuron remodeling cell projection neuron projection ephrin receptor binding ephrin receptor signaling pathway regulation of ephrin receptor signaling pathway negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc008bpx.1 uc008bpx.2 uc008bpx.3 uc008bpx.4 
ENSMUST00000114848.8 Taf11 ENSMUST00000114848.8 TATA-box binding protein associated factor 11, transcript variant 2 (from RefSeq NM_026836.3) ENSMUST00000114848.1 ENSMUST00000114848.2 ENSMUST00000114848.3 ENSMUST00000114848.4 ENSMUST00000114848.5 ENSMUST00000114848.6 ENSMUST00000114848.7 NM_026836 Q3UZH1 Q99JX1 Q9CT98 TAF11_MOUSE uc008bpu.1 uc008bpu.2 uc008bpu.3 The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF11, together with TAF13 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes. Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP- associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TAF13 both in vitro and intracellularly; also interacts directly with TBP. Q99JX1; P61216: Taf13; NbExp=3; IntAct=EBI-309427, EBI-309424; Nucleus TBP and TAFII18 bind to distinct domains of TAFII28. Belongs to the TAF11 family. DNA binding transcription coactivator activity nucleus nucleoplasm transcription factor TFIID complex Golgi apparatus transcription initiation from RNA polymerase II promoter transcription factor binding vitamin D receptor binding positive regulation by host of viral transcription thyroid hormone receptor binding protein heterodimerization activity protein N-terminus binding RNA polymerase II transcriptional preinitiation complex assembly positive regulation of nucleic acid-templated transcription uc008bpu.1 uc008bpu.2 uc008bpu.3 
ENSMUST00000114849.3 Bltp3a ENSMUST00000114849.3 bridge-like lipid transfer protein family member 3A (from RefSeq NM_001080769.1) B2KF50 B2KF50_MOUSE Bltp3a ENSMUST00000114849.1 ENSMUST00000114849.2 NM_001080769 Uhrf1bp1 uc008bpt.1 uc008bpt.2 uc008bpt.3 cellular_component biological_process identical protein binding histone deacetylase binding uc008bpt.1 uc008bpt.2 uc008bpt.3 
ENSMUST00000114850.3 Cstdc6 ENSMUST00000114850.3 cystatin domain containing 6 (from RefSeq NM_001001332.2) BC117090 Cstdc6 ENSMUST00000114850.1 ENSMUST00000114850.2 L7N257 L7N257_MOUSE NM_001001332 uc007zcl.1 uc007zcl.2 Belongs to the cystatin family. endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity cytosol negative regulation of endopeptidase activity uc007zcl.1 uc007zcl.2 
ENSMUST00000114854.8 A630012P03Rik ENSMUST00000114854.8 A630012P03Rik (from geneSymbol) AK041468 ENSMUST00000114854.1 ENSMUST00000114854.2 ENSMUST00000114854.3 ENSMUST00000114854.4 ENSMUST00000114854.5 ENSMUST00000114854.6 ENSMUST00000114854.7 uc292odh.1 uc292odh.2 uc292odh.1 uc292odh.2 
ENSMUST00000114858.2 Cstdc4 ENSMUST00000114858.2 cystatin domain containing 4 (from RefSeq NM_001082547.1) B2RV77 B2RV77_MOUSE Cstdc4 EG433016 ENSMUST00000114858.1 Gm5483 NM_001082547 uc007zch.1 uc007zch.2 uc007zch.3 Belongs to the cystatin family. cornified envelope protease binding endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular space nucleus cytoplasm cytosol negative regulation of endopeptidase activity uc007zch.1 uc007zch.2 uc007zch.3 
ENSMUST00000114863.10 Ilrun ENSMUST00000114863.10 inflammation and lipid regulator with UBA-like and NBR1-like domains, transcript variant 1 (from RefSeq NM_001033279.3) A2RT11 D17Wsu92e ENSMUST00000114863.1 ENSMUST00000114863.2 ENSMUST00000114863.3 ENSMUST00000114863.4 ENSMUST00000114863.5 ENSMUST00000114863.6 ENSMUST00000114863.7 ENSMUST00000114863.8 ENSMUST00000114863.9 ILRUN_MOUSE Ilrun NM_001033279 Q3TT38 uc008bpq.1 uc008bpq.2 uc008bpq.3 uc008bpq.4 Negative regulator of innate antiviral response. Blocks IRF3- dependent cytokine production such as IFNA, IFNB and TNF. Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP. Interacts with IRF3; the interaction inhibits IRF3 binding to its DNA consensus sequence. Cytoplasm Nucleus pre-autophagosomal structure immune system process nucleus cytoplasm autophagosome macroautophagy negative regulation of type I interferon production negative regulation of tumor necrosis factor production ubiquitin binding negative regulation of DNA binding innate immune response negative regulation of defense response to virus negative regulation of protein localization to nucleus uc008bpq.1 uc008bpq.2 uc008bpq.3 uc008bpq.4 
ENSMUST00000114865.8 Grik4 ENSMUST00000114865.8 glutamate receptor, ionotropic, kainate 4 (from RefSeq NM_175481.5) E9QNA2 ENSMUST00000114865.1 ENSMUST00000114865.2 ENSMUST00000114865.3 ENSMUST00000114865.4 ENSMUST00000114865.5 ENSMUST00000114865.6 ENSMUST00000114865.7 GRIK4_MOUSE NM_175481 Q8BMF5 uc009paz.1 uc009paz.2 uc009paz.3 uc009paz.4 Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA (By similarity). Forms a heteromeric channel with GRIK1 or GRIK3. Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi- pass membrane protein Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily. ionotropic glutamate receptor activity ion channel activity protein binding nucleus plasma membrane ion transport glutamate receptor activity ligand-gated ion channel activity kainate selective glutamate receptor activity membrane integral component of membrane cell junction axon dendrite kainate selective glutamate receptor complex ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic signaling receptor activity presynaptic membrane terminal bouton perikaryon synapse postsynaptic membrane modulation of synaptic transmission regulation of postsynaptic membrane potential postsynaptic density membrane glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc009paz.1 uc009paz.2 uc009paz.3 uc009paz.4 
ENSMUST00000114869.8 Usp26 ENSMUST00000114869.8 ubiquitin specific peptidase 26 (from RefSeq NM_031388.2) ENSMUST00000114869.1 ENSMUST00000114869.2 ENSMUST00000114869.3 ENSMUST00000114869.4 ENSMUST00000114869.5 ENSMUST00000114869.6 ENSMUST00000114869.7 NM_031388 Q05A11 Q99MX1 UBP26_MOUSE Usp26 uc009tec.1 uc009tec.2 Deubiquitinase regulating several biological processes through the deubiquitination of components of these processes (PubMed:28839133). Involved in somatic cell reprogramming through the 'Lys-48'-linked deubiquitination and stabilization of CBX4 and CBX6, two components of the polycomb-repressive complex 1 (PRC1) (By similarity). Also deubiquitinates and probably stabilizes the androgen receptor (AR), regulating the androgen receptor signaling pathway (By similarity). May play a role in spermatogenesis (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with RING1. Nucleus Cytoplasm, cytoskeleton, flagellum axoneme Belongs to the peptidase C19 family. G1/S transition of mitotic cell cycle cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity uc009tec.1 uc009tec.2 
ENSMUST00000114871.2 Hs6st2 ENSMUST00000114871.2 heparan sulfate 6-O-sulfotransferase 2, transcript variant 2 (from RefSeq NM_015819.5) A2AEM4 ENSMUST00000114871.1 H6ST2_MOUSE NM_015819 Q3TAR0 Q6P4N9 Q80UW0 Q8C785 Q9QYK6 uc009tdz.1 uc009tdz.2 uc009tdz.3 uc009tdz.4 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:56604, Rhea:RHEA- COMP:9830, Rhea:RHEA-COMP:14621, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:140604; Membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80UW0-1; Sequence=Displayed; Name=2; IsoId=Q80UW0-2; Sequence=VSP_015848; Name=3; IsoId=Q80UW0-3; Sequence=VSP_015849; Belongs to the sulfotransferase 6 family. Sequence=BAC34950.1; Type=Erroneous initiation; Evidence=; nucleoplasm sulfotransferase activity heparan sulfate proteoglycan biosynthetic process, enzymatic modification membrane integral component of membrane transferase activity heparan sulfate 6-O-sulfotransferase activity uc009tdz.1 uc009tdz.2 uc009tdz.3 uc009tdz.4 
ENSMUST00000114874.5 Clec2l ENSMUST00000114874.5 C-type lectin domain family 2, member L (from RefSeq NM_001101507.1) CLC2L_MOUSE ENSMUST00000114874.1 ENSMUST00000114874.2 ENSMUST00000114874.3 ENSMUST00000114874.4 NM_001101507 P0C7M9 uc029vuf.1 uc029vuf.2 uc029vuf.3 uc029vuf.4 Membrane ; Single-pass membrane protein cellular_component biological_process membrane integral component of membrane carbohydrate binding uc029vuf.1 uc029vuf.2 uc029vuf.3 uc029vuf.4 
ENSMUST00000114876.9 Mbnl3 ENSMUST00000114876.9 muscleblind like splicing factor 3, transcript variant 1 (from RefSeq NM_134163.5) Chcr ENSMUST00000114876.1 ENSMUST00000114876.2 ENSMUST00000114876.3 ENSMUST00000114876.4 ENSMUST00000114876.5 ENSMUST00000114876.6 ENSMUST00000114876.7 ENSMUST00000114876.8 MBNL3_MOUSE Mbxl NM_134163 Q8R003 uc009tdu.1 uc009tdu.2 uc009tdu.3 uc009tdu.4 Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins (By similarity). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. Nucleus Cytoplasm Note=Mostly nuclear. High expression in proliferating myoblasts is strongly reduced in differentiated muscle cells. Belongs to the muscleblind family. regulation of alternative mRNA splicing, via spliceosome RNA binding nucleus nucleoplasm cytoplasm mRNA processing multicellular organism development RNA splicing regulation of RNA splicing negative regulation of myoblast differentiation metal ion binding uc009tdu.1 uc009tdu.2 uc009tdu.3 uc009tdu.4 
ENSMUST00000114878.8 Parp9 ENSMUST00000114878.8 poly (ADP-ribose) polymerase family, member 9, transcript variant 3 (from RefSeq NM_030253.4) Bal ENSMUST00000114878.1 ENSMUST00000114878.2 ENSMUST00000114878.3 ENSMUST00000114878.4 ENSMUST00000114878.5 ENSMUST00000114878.6 ENSMUST00000114878.7 NM_030253 PARP9_MOUSE Q6IRT6 Q8CAS9 Q99LF9 uc007zby.1 uc007zby.2 uc007zby.3 uc007zby.4 ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (By similarity). In addition, positively regulates DTXL3 protein levels (By similarity). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (By similarity). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (By similarity). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (By similarity). In response to DNA damage, PARP9-DTX3L complex is required for efficient non- homologous end joining (NHEJ) but the complex function is restrained by PARP9 activity (By similarity). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (PubMed:28105679). In macrophages, positively regulates pro- inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14- mediated STAT6 ADP-ribosylation (By similarity). Reaction=[protein]-C-terminal glycine + NAD(+) = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide; Xref=Rhea:RHEA:58268, Rhea:RHEA-COMP:15093, Rhea:RHEA-COMP:15095, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:83148, ChEBI:CHEBI:142558; Evidence=; Binding to poly(ADP-ribose) does not affect its activity. Forms a stable complex with E3 ligase DTX3L; the interaction is required for PARP9 mediated ADP-ribosylation of ubiquitin. Interacts (via PARP catalytic domain) with DTX3L (via N-terminus). Forms a complex with STAT1 and DTX3L independently of IFNB1 or IFNG-mediated STAT1 'Tyr-701' phosphorylation. Forms a complex with STAT1, DTX3L and histone H2B H2BC9/H2BJ; the interaction is likely to induce H2BC9/H2BJ ubiquitination. Interacts (via N-terminus) with STAT1. Interacts with PARP14 in IFNG-stimulated macrophages; the interaction prevents PARP14- mediated STAT1 and STAT6 ADP-riboslylation. Interacts with PARP1 (when poly-ADP-ribosylated). Cytoplasm, cytosol Nucleus Note=Shuttles between the nucleus and the cytosol. Translocates to the nucleus in response to IFNG or IFNB1 stimulation. Export to the cytosol depends on the interaction with DTX3L. Localizes at sites of DNA damage in a PARP1-dependent manner. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CAS9-1; Sequence=Displayed; Name=2; IsoId=Q8CAS9-2; Sequence=VSP_008506; Name=3; IsoId=Q8CAS9-3; Sequence=VSP_008507; Highly expressed in the thymus and intestine (PubMed:18069692). Expressed in macrophages (PubMed:27796300). Developmentally regulated. Expressed prominently in the developing thymus and the gut, and also weakly expressed in specific regions of the developing brain. Up-regulated by IFNG in macrophages. Down-regulated by IL4 in macrophages. Macro domains 1 and 2 may be involved in the binding to poly(ADP-ribose). Macro domain 2 is required for recruitment to DNA damage sites. Macro domains 1 and 2 are probably dispensable for the interaction with STAT1 and DTX3L and for STAT1 phosphorylation. ADP-ribosylated by PARP14. No visible phenotype. Mice are viable, fertile and are born at the expected Mendelian rate with a slight decrease in male frequency. No defect in B-cell development, maturation and maintenance in periphery. Slight decrease in the number of follicular B-cell associated with an increase in the number of marginal zone B- cells. Belongs to the ARTD/PARP family. negative regulation of transcription from RNA polymerase II promoter positive regulation of defense response to virus by host immune system process transcription corepressor activity NAD+ ADP-ribosyltransferase activity enzyme inhibitor activity nucleus nucleoplasm cytoplasm mitochondrion cytosol DNA repair double-strand break repair protein ADP-ribosylation cellular response to DNA damage stimulus posttranscriptional regulation of gene expression negative regulation of gene expression transferase activity enzyme binding macromolecular complex positive regulation of chromatin binding histone binding positive regulation of tyrosine phosphorylation of STAT protein negative regulation of catalytic activity ubiquitin-like protein ligase binding innate immune response positive regulation of transcription, DNA-templated defense response to virus regulation of response to interferon-gamma positive regulation of interferon-gamma-mediated signaling pathway ADP-D-ribose binding STAT family protein binding positive regulation of protein localization to nucleus positive regulation of double-strand break repair via nonhomologous end joining uc007zby.1 uc007zby.2 uc007zby.3 uc007zby.4 
ENSMUST00000114881.9 Rps10 ENSMUST00000114881.9 Belongs to the eukaryotic ribosomal protein eS10 family. (from UniProt Q5M9K7) BC003853 ENSMUST00000114881.1 ENSMUST00000114881.2 ENSMUST00000114881.3 ENSMUST00000114881.4 ENSMUST00000114881.5 ENSMUST00000114881.6 ENSMUST00000114881.7 ENSMUST00000114881.8 Q5M9K7 Q5M9K7_MOUSE Rps10 uc289itx.1 uc289itx.2 Belongs to the eukaryotic ribosomal protein eS10 family. ribosome uc289itx.1 uc289itx.2 
ENSMUST00000114884.8 Rbm33 ENSMUST00000114884.8 Rbm33 (from geneSymbol) AK078210 D3Z5I9 D3Z5I9_MOUSE ENSMUST00000114884.1 ENSMUST00000114884.2 ENSMUST00000114884.3 ENSMUST00000114884.4 ENSMUST00000114884.5 ENSMUST00000114884.6 ENSMUST00000114884.7 Rbm33 uc290twi.1 uc290twi.2 nucleic acid binding uc290twi.1 uc290twi.2 
ENSMUST00000114888.11 Hmga1 ENSMUST00000114888.11 high mobility group AT-hook 1, transcript variant 61 (from RefSeq NM_001413144.1) ENSMUST00000114888.1 ENSMUST00000114888.10 ENSMUST00000114888.2 ENSMUST00000114888.3 ENSMUST00000114888.4 ENSMUST00000114888.5 ENSMUST00000114888.6 ENSMUST00000114888.7 ENSMUST00000114888.8 ENSMUST00000114888.9 NM_001413144 Q3TVP0 Q3TVP0_MOUSE uc008bpd.1 uc008bpd.2 uc008bpd.3 uc008bpd.4 HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. Interacts with HIPK2. Chromosome Nucleus Belongs to the HMGA family. chromatin DNA binding nucleus regulation of transcription, DNA-templated uc008bpd.1 uc008bpd.2 uc008bpd.3 uc008bpd.4 
ENSMUST00000114894.2 Lyg1 ENSMUST00000114894.2 lysozyme G-like 1 (from RefSeq NM_027111.3) ENSMUST00000114894.1 LYG1_MOUSE NM_027111 Q9D7Q0 uc007asl.1 uc007asl.2 Secreted Belongs to the glycosyl hydrolase 23 family. lysozyme activity extracellular region metabolic process peptidoglycan catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds cell wall macromolecule catabolic process defense response to Gram-positive bacterium uc007asl.1 uc007asl.2 
ENSMUST00000114895.4 Cfap53 ENSMUST00000114895.4 cilia and flagella associated protein 53, transcript variant 1 (from RefSeq NM_028948.2) CFA53_MOUSE Ccdc11 Cfap53 ENSMUST00000114895.1 ENSMUST00000114895.2 ENSMUST00000114895.3 NM_028948 Q4KL15 Q9D439 uc008fpm.1 uc008fpm.2 uc008fpm.3 uc008fpm.4 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis (By similarity). Interacts with PIERCE1 and PIERCE2; the interactions link outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme. Cytoplasm, cytoskeleton, cilium axoneme Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D439-1; Sequence=Displayed; Name=2; IsoId=Q9D439-2; Sequence=VSP_057233; Belongs to the CFAP53 family. Sequence=AAH99500.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cilium movement molecular_function cellular_component extracellular region cilium multicellular organism development determination of left/right symmetry cell projection cilium assembly epithelial cilium movement involved in determination of left/right asymmetry uc008fpm.1 uc008fpm.2 uc008fpm.3 uc008fpm.4 
ENSMUST00000114897.9 Atp5f1c ENSMUST00000114897.9 ATP synthase F1 subunit gamma, transcript variant 1 (from RefSeq NM_020615.4) ATPG_MOUSE Atp5c1 Atp5f1c ENSMUST00000114897.1 ENSMUST00000114897.2 ENSMUST00000114897.3 ENSMUST00000114897.4 ENSMUST00000114897.5 ENSMUST00000114897.6 ENSMUST00000114897.7 ENSMUST00000114897.8 NM_020615 Q91VR2 uc008ihm.1 uc008ihm.2 uc008ihm.3 uc008ihm.4 uc008ihm.5 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT- ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the ATPase gamma chain family. mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) mitochondrion mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex ATP biosynthetic process ion transport ATP synthesis coupled proton transport membrane ATPase activity myelin sheath proton-transporting ATP synthase complex, catalytic core F(1) ATP metabolic process proton-transporting ATP synthase activity, rotational mechanism uc008ihm.1 uc008ihm.2 uc008ihm.3 uc008ihm.4 uc008ihm.5 
ENSMUST00000114900.8 Zc3hav1 ENSMUST00000114900.8 zinc finger CCCH type, antiviral 1, transcript variant 3 (from RefSeq NM_001347122.1) D3Z5I1 D3Z5I1_MOUSE ENSMUST00000114900.1 ENSMUST00000114900.2 ENSMUST00000114900.3 ENSMUST00000114900.4 ENSMUST00000114900.5 ENSMUST00000114900.6 ENSMUST00000114900.7 NM_001347122 Zc3hav1 uc057lps.1 uc057lps.2 uc057lps.3 Belongs to the ARTD/PARP family. NAD+ ADP-ribosyltransferase activity cytosol response to virus negative regulation of viral genome replication metal ion binding positive regulation of mRNA catabolic process uc057lps.1 uc057lps.2 uc057lps.3 
ENSMUST00000114912.8 Enox2 ENSMUST00000114912.8 ecto-NOX disulfide-thiol exchanger 2, transcript variant 6 (from RefSeq NM_001271451.1) B1B073 Cova1 ENOX2_MOUSE ENSMUST00000114912.1 ENSMUST00000114912.2 ENSMUST00000114912.3 ENSMUST00000114912.4 ENSMUST00000114912.5 ENSMUST00000114912.6 ENSMUST00000114912.7 NM_001271451 Q8BY59 Q8R0Z2 Q8R372 uc009tcz.1 uc009tcz.2 uc009tcz.3 uc009tcz.4 May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock (By similarity). Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, and retinoids. Cell membrane Secreted, extracellular space Note=Extracellular and plasma membrane-associated. Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q8R0Z2-1; Sequence=Displayed; Name=2 ; IsoId=Q8R0Z2-2; Sequence=VSP_051830; Name=3 ; IsoId=Q8R0Z2-3; Sequence=VSP_051831; Glycosylated. Belongs to the ENOX family. nucleic acid binding extracellular region extracellular space plasma membrane ultradian rhythm external side of plasma membrane protein disulfide oxidoreductase activity membrane oxidoreductase activity regulation of growth rhythmic process oxidation-reduction process uc009tcz.1 uc009tcz.2 uc009tcz.3 uc009tcz.4 
ENSMUST00000114913.3 Adcy5 ENSMUST00000114913.3 adenylate cyclase 5, transcript variant 3 (from RefSeq NM_001417056.1) ADCY5_MOUSE Adcy5 ENSMUST00000114913.1 ENSMUST00000114913.2 NM_001417056 P84309 Q3TU67 Q3UH09 Q5BL06 uc007zbj.1 uc007zbj.2 uc007zbj.3 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion. Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro). ; Activated by forskolin. Activated by GNAS. Activity is further increased by interaction with the G protein beta and gamma subunit complex formed by GNB1 and GNG2 (By similarity). Is not activated by calmodulin. Inhibited by adenosine and ATP analogs. Inhibited by calcium ions, already at micromolar concentrations (By similarity). Phosphorylation by RAF1 results in its activation (By similarity). Interacts with GNAS, GNB1 and GNG2 (By similarity). Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 (PubMed:21670265). Interacts with RAF1 (By similarity). Cell membrane ; Multi-pass membrane protein Cell projection, cilium Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P84309-1; Sequence=Displayed; Name=2; IsoId=P84309-2; Sequence=VSP_022224; The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate- binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain. Phosphorylated by RAF1. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding adenosine receptor signaling pathway adenylate cyclase activity protein binding ATP binding endosome plasma membrane integral component of plasma membrane cilium cAMP biosynthetic process adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway adenylate cyclase-inhibiting dopamine receptor signaling pathway positive regulation of cytosolic calcium ion concentration locomotory behavior adenylate cyclase binding calcium- and calmodulin-responsive adenylate cyclase activity cyclic nucleotide biosynthetic process membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity intracellular signal transduction cell projection intermediate filament cytoskeleton membrane raft metal ion binding protein heterodimerization activity neuromuscular process controlling balance regulation of insulin secretion involved in cellular response to glucose stimulus scaffold protein binding cellular response to forskolin sarcolemma uc007zbj.1 uc007zbj.2 uc007zbj.3 
ENSMUST00000114924.10 Celf2 ENSMUST00000114924.10 CUGBP, Elav-like family member 2, transcript variant 36 (from RefSeq NM_001406924.1) A2AS10 A2AS11 A2AS15 CELF2_MOUSE Cugbp2 ENSMUST00000114924.1 ENSMUST00000114924.2 ENSMUST00000114924.3 ENSMUST00000114924.4 ENSMUST00000114924.5 ENSMUST00000114924.6 ENSMUST00000114924.7 ENSMUST00000114924.8 ENSMUST00000114924.9 NM_001406924 Napor Q3TNX4 Q3TTI4 Q3TUB8 Q3U668 Q3U7J8 Q3U9F2 Q3UVH4 Q9R0B2 Q9Z0H4 Q9Z187 uc012bpa.1 uc012bpa.2 uc012bpa.3 uc012bpa.4 uc012bpa.5 RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (By similarity). Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle (By similarity). Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB (By similarity). Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (By similarity). Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA (By similarity). Involved in the apoB RNA editing activity (By similarity). Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK (By similarity). Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5 (By similarity). Binds preferentially to UG- rich sequences, in particular UG repeat and UGUU motifs (By similarity). Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine (By similarity). Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (By similarity). Interacts with A1CF. Nucleus Cytoplasm Note=Colocalizes with APOBEC1 and A1CF (By similarity). RNA-binding activity is detected in both nuclear and cytoplasmic compartments (By similarity). Accumulates in the cytoplasm after ionizing radiation. Event=Alternative splicing; Named isoforms=10; Name=1; Synonyms=Napor-3; IsoId=Q9Z0H4-1; Sequence=Displayed; Name=2; IsoId=Q9Z0H4-2; Sequence=VSP_026803; Name=3; IsoId=Q9Z0H4-3; Sequence=VSP_026801, VSP_026806; Name=4; IsoId=Q9Z0H4-4; Sequence=VSP_026802, VSP_026805; Name=5; IsoId=Q9Z0H4-5; Sequence=VSP_026802, VSP_026806; Name=6; IsoId=Q9Z0H4-6; Sequence=VSP_026803, VSP_026806; Name=7; Synonyms=Napor-1; IsoId=Q9Z0H4-7; Sequence=VSP_026802; Name=8; IsoId=Q9Z0H4-8; Sequence=VSP_026806; Name=9; IsoId=Q9Z0H4-9; Sequence=VSP_026804; Name=11; IsoId=Q9Z0H4-11; Sequence=VSP_026806, VSP_026808; Expressed in tongue, spleen and brain (at protein level). Expressed in liver, thigh, stomach, lung and heart to very low levels (at protein level). Expressed in heart, brain, lung and muscle. Expressed in heart, muscle, brain, liver, thigh, stomach and lung at 14 dpc (at protein level). Expressed in embryo at 7, 11 and 17 dpc. Expressed in the developing central nervous system from 12 to 16 dpc. Up-regulated following ionizing radiation in the crypt epithelial cells of the intestin. Down-regulated by bacterial lipopolysaccharides (LPS). Down-regulated by prostaglandin E2 following ionizing radiation. [Isoform 9]: Gene prediction based on similarity to rat ortholog. Belongs to the CELF/BRUNOL family. Sequence=BAE31371.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; [Isoform 7]: Sequence=CAA77110.1; Type=Frameshift; Evidence=; regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding nucleus cytoplasm mRNA splice site selection mRNA processing pre-mRNA binding ribonucleoprotein complex uc012bpa.1 uc012bpa.2 uc012bpa.3 uc012bpa.4 uc012bpa.5 
ENSMUST00000114928.2 Fsip2l ENSMUST00000114928.2 fibrous sheath-interacting protein 2-like (from RefSeq NM_001085499.1) A2AF73 A2AF73_MOUSE ENSMUST00000114928.1 Fsip2l Gm595 NM_001085499 uc009tcu.1 uc009tcu.2 molecular_function biological_process uc009tcu.1 uc009tcu.2 
ENSMUST00000114935.9 Cuta ENSMUST00000114935.9 cutA divalent cation tolerance homolog, transcript variant 2 (from RefSeq NM_026948.3) Cuta D5MCW4 D5MCW4_MOUSE ENSMUST00000114935.1 ENSMUST00000114935.2 ENSMUST00000114935.3 ENSMUST00000114935.4 ENSMUST00000114935.5 ENSMUST00000114935.6 ENSMUST00000114935.7 ENSMUST00000114935.8 NM_026948 uc008bez.1 uc008bez.2 uc008bez.3 uc008bez.4 uc008bez.5 Homotrimer. Belongs to the CutA family. response to metal ion uc008bez.1 uc008bez.2 uc008bez.3 uc008bez.4 uc008bez.5 
ENSMUST00000114937.8 Usp6nl ENSMUST00000114937.8 USP6 N-terminal like, transcript variant 2 (from RefSeq NM_001080548.1) A2AR45 A2AR46 ENSMUST00000114937.1 ENSMUST00000114937.2 ENSMUST00000114937.3 ENSMUST00000114937.4 ENSMUST00000114937.5 ENSMUST00000114937.6 ENSMUST00000114937.7 Kiaa0019 NM_001080548 Q3U2W3 Q6ZQK8 Q80XC3 US6NL_MOUSE uc008igk.1 uc008igk.2 uc008igk.3 Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex (By similarity). Interacts with EPS8. Golgi apparatus Cytoplasmic vesicle Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80XC3-1; Sequence=Displayed; Name=2; IsoId=Q80XC3-2; Sequence=VSP_011153; Sequence=BAC97847.1; Type=Erroneous initiation; Evidence=; Sequence=BC051184; Type=Frameshift; Evidence=; GTPase activator activity Golgi apparatus plasma membrane intracellular protein transport Golgi organization Rab GTPase binding virion assembly cytoplasmic vesicle retrograde transport, plasma membrane to Golgi positive regulation of GTPase activity plasma membrane to endosome transport activation of GTPase activity regulation of Golgi organization uc008igk.1 uc008igk.2 uc008igk.3 
ENSMUST00000114942.9 Proser2 ENSMUST00000114942.9 proline and serine rich 2, transcript variant 2 (from RefSeq NM_144883.5) ENSMUST00000114942.1 ENSMUST00000114942.2 ENSMUST00000114942.3 ENSMUST00000114942.4 ENSMUST00000114942.5 ENSMUST00000114942.6 ENSMUST00000114942.7 ENSMUST00000114942.8 NM_144883 PRSR2_MOUSE Q3V1L9 Q8C5R2 Q8R017 Q8R2Z9 uc008ige.1 uc008ige.2 uc008ige.3 uc008ige.4 Sequence=AAH26904.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process uc008ige.1 uc008ige.2 uc008ige.3 uc008ige.4 
ENSMUST00000114943.11 Dcc ENSMUST00000114943.11 deleted in colorectal carcinoma (from RefSeq NM_007831.3) DCC_MOUSE ENSMUST00000114943.1 ENSMUST00000114943.10 ENSMUST00000114943.2 ENSMUST00000114943.3 ENSMUST00000114943.4 ENSMUST00000114943.5 ENSMUST00000114943.6 ENSMUST00000114943.7 ENSMUST00000114943.8 ENSMUST00000114943.9 G3X9X6 NM_007831 P70211 uc008fop.1 uc008fop.2 uc008fop.3 uc008fop.4 Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D (By similarity). Interacts with MAPK1 (By similarity). Interacts with NTN1 (By similarity). Interacts with DSCAM (PubMed:18585357). Interacts with PTK2/FAK1 (PubMed:15494734). Interacts with MYO10 (PubMed:21321230). Interacts with CBLN4; this interaction can be competed by NTN1 (PubMed:22220752, PubMed:29782851). Interacts with SIAH1 and SIAH2 (By similarity). P70211; Q9ERC8: Dscam; NbExp=4; IntAct=EBI-1798863, EBI-1798601; P70211; P56671: Maz; NbExp=3; IntAct=EBI-1798863, EBI-1809712; P70211; P56270: MAZ; Xeno; NbExp=2; IntAct=EBI-1798863, EBI-1809742; Membrane; Single-pass type I membrane protein. Event=Alternative splicing, Alternative initiation; Named isoforms=3; Name=A; IsoId=P70211-1; Sequence=Displayed; Name=C; IsoId=P70211-2; Sequence=VSP_002501; Name=B; IsoId=P70211-3; Sequence=VSP_018807; In the embryo, expressed at high levels in the developing brain and neural tube. In the embryo, expressed in developing neurons of the telencephalic cortical plate and in developing brainstem nuclei (PubMed:28250456). In adult, highly expressed in brain with very low levels found in testis, heart and thymus. Isoform C is expressed only in the embryo. Low levels in early gestation. Highest levels expressed during mid gestation. Levels decrease in late gestation and remain at this level in the adult. Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. [Isoform B]: Produced by alternative initiation at Met- 85 of isoform A. Belongs to the immunoglobulin superfamily. DCC family. neuron migration transcription coactivator activity netrin receptor activity protein binding plasma membrane apoptotic process multicellular organism development nervous system development axon guidance positive regulation of neuron projection development membrane integral component of membrane spinal cord ventral commissure morphogenesis axon growth cone membrane dorsal/ventral axon guidance anterior/posterior axon guidance netrin-activated signaling pathway identical protein binding membrane raft positive regulation of ERK1 and ERK2 cascade integral component of postsynaptic density membrane regulation of neuron death positive regulation of nucleic acid-templated transcription uc008fop.1 uc008fop.2 uc008fop.3 uc008fop.4 
ENSMUST00000114945.9 Aifm1 ENSMUST00000114945.9 apoptosis-inducing factor, mitochondrion-associated 1, transcript variant 2 (from RefSeq NM_001290364.1) Aifm1 B1AU25 B1AU25_MOUSE ENSMUST00000114945.1 ENSMUST00000114945.2 ENSMUST00000114945.3 ENSMUST00000114945.4 ENSMUST00000114945.5 ENSMUST00000114945.6 ENSMUST00000114945.7 ENSMUST00000114945.8 NM_001290364 uc057arf.1 uc057arf.2 uc057arf.3 Reaction=A + H(+) + NADH = AH2 + NAD(+); Xref=Rhea:RHEA:11356, ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:17499, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Belongs to the FAD-dependent oxidoreductase family. membrane integral component of membrane oxidoreductase activity protein dimerization activity flavin adenine dinucleotide binding oxidation-reduction process uc057arf.1 uc057arf.2 uc057arf.3 
ENSMUST00000114959.9 Stard6 ENSMUST00000114959.9 StAR related lipid transfer domain containing 6, transcript variant 1 (from RefSeq NM_029019.4) ENSMUST00000114959.1 ENSMUST00000114959.2 ENSMUST00000114959.3 ENSMUST00000114959.4 ENSMUST00000114959.5 ENSMUST00000114959.6 ENSMUST00000114959.7 ENSMUST00000114959.8 NM_029019 Q9CPT8 Q9CPT8_MOUSE Stard6 uc008fog.1 uc008fog.2 uc008fog.3 uc008fog.4 May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. lipid binding uc008fog.1 uc008fog.2 uc008fog.3 uc008fog.4 
ENSMUST00000114965.2 Galntl5 ENSMUST00000114965.2 Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; (from UniProt D3Z533) BC100447 D3Z533 D3Z533_MOUSE ENSMUST00000114965.1 Galntl5 uc012dtk.1 uc012dtk.2 uc012dtk.3 Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. uc012dtk.1 uc012dtk.2 uc012dtk.3 
ENSMUST00000114976.9 Luc7l ENSMUST00000114976.9 Luc7-like, transcript variant 2 (from RefSeq NM_028190.3) ENSMUST00000114976.1 ENSMUST00000114976.2 ENSMUST00000114976.3 ENSMUST00000114976.4 ENSMUST00000114976.5 ENSMUST00000114976.6 ENSMUST00000114976.7 ENSMUST00000114976.8 LUC7L_MOUSE NM_028190 Q8K247 Q9CWM1 Q9CYI4 uc008beb.1 uc008beb.2 uc008beb.3 uc008beb.4 May bind to RNA via its Arg/Ser-rich domain. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CYI4-1; Sequence=Displayed; Name=2; IsoId=Q9CYI4-2; Sequence=VSP_010216; Belongs to the Luc7 family. mRNA binding protein binding nucleus U1 snRNP mRNA splice site selection identical protein binding negative regulation of striated muscle tissue development RS domain binding U2-type prespliceosome uc008beb.1 uc008beb.2 uc008beb.3 uc008beb.4 
ENSMUST00000114985.10 Tcf4 ENSMUST00000114985.10 transcription factor 4, transcript variant 1 (from RefSeq NM_013685.2) ENSMUST00000114985.1 ENSMUST00000114985.2 ENSMUST00000114985.3 ENSMUST00000114985.4 ENSMUST00000114985.5 ENSMUST00000114985.6 ENSMUST00000114985.7 ENSMUST00000114985.8 ENSMUST00000114985.9 ITF2_MOUSE Itf2 NM_013685 Q60721 Q60722 Q62211 Q64072 Q80UE8 Sef2 uc008fnq.1 uc008fnq.2 uc008fnq.3 Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3'). Isoform 2 inhibits MYOD1 activation of the cardiac alpha- actin promoter. Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. May have a regulatory function in developmental processes as well as during neuronal plasticity. Efficient DNA binding requires dimerization with another bHLH protein. Isoform 2 seems to form inactive heterodimers with MYOD1. Interacts with HIVEP2. Interacts with NEUROD2. Interacts with AGBL1 (By similarity). Interacts with BHLHA9. Q60722; O54972: Cbfa2t3; NbExp=2; IntAct=EBI-310070, EBI-8006703; Q60722; P70662: Ldb1; NbExp=2; IntAct=EBI-310070, EBI-6272082; Q60722; O54826: Mllt10; NbExp=3; IntAct=EBI-310070, EBI-8459555; Nucleus Event=Alternative splicing; Named isoforms=3; Name=2; Synonyms=MITF-2B; IsoId=Q60722-1; Sequence=Displayed; Name=1; Synonyms=MITF-2A; IsoId=Q60722-2; Sequence=VSP_002113, VSP_002114; Name=3; Synonyms=MITF-2B-delta; IsoId=Q60722-3; Sequence=VSP_002115; Expressed in the cerebral cortex, Purkinje and granule cell layers of the cerebellum, olfactory neuroepithelium, pyramidal cells of hippocampal layers CA1-CA4, and in the granular cells of the dentate gyrus. Expressed in proliferative zones during development and in the adult in areas of neuronal plasticity. At 12 dpc, expression is localized in the cortex, cerebellum, pons, medulla and spinal cord. From 18 dpc to adulthood, high levels of expression are found in the pyramidal cells of hippocampal layers CA1-CA4, and in the granular cells of the dentate gyrus. At postnatal day 7, expression is high in the visual cortex and in the subependymal region extending from the anterior lateral ventricle into the olfactory bulb. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding TFIIB-class transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus transcription factor complex DNA-templated transcription, initiation regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter multicellular organism development nervous system development protein C-terminus binding negative regulation of gene expression negative regulation of angiogenesis cell differentiation endothelial cell activation identical protein binding protein homodimerization activity bHLH transcription factor binding protein self-association positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity protein-DNA complex assembly beta-catenin-TCF7L2 complex E-box binding regulation of vascular endothelial growth factor signaling pathway beta-catenin-TCF complex uc008fnq.1 uc008fnq.2 uc008fnq.3 
ENSMUST00000114988.8 Fam234a ENSMUST00000114988.8 Membrane ; Single-pass type II membrane protein (from UniProt Q8C0Z1) AK158049 ENSMUST00000114988.1 ENSMUST00000114988.2 ENSMUST00000114988.3 ENSMUST00000114988.4 ENSMUST00000114988.5 ENSMUST00000114988.6 ENSMUST00000114988.7 F234A_MOUSE Fam234a Itfg3 Q3TZ74 Q8C0Z1 uc008bdw.1 uc008bdw.2 uc008bdw.3 uc008bdw.4 Membrane ; Single-pass type II membrane protein Belongs to the FAM234 family. molecular_function biological_process cell surface membrane integral component of membrane uc008bdw.1 uc008bdw.2 uc008bdw.3 uc008bdw.4 
ENSMUST00000114993.9 Cnot4 ENSMUST00000114993.9 CCR4-NOT transcription complex, subunit 4, transcript variant 9 (from RefSeq NM_001410685.1) A0A0R4J1K1 A0A0R4J1K1_MOUSE Cnot4 ENSMUST00000114993.1 ENSMUST00000114993.2 ENSMUST00000114993.3 ENSMUST00000114993.4 ENSMUST00000114993.5 ENSMUST00000114993.6 ENSMUST00000114993.7 ENSMUST00000114993.8 NM_001410685 uc009bid.1 uc009bid.2 uc009bid.3 uc009bid.4 nucleic acid binding RNA binding ubiquitin-protein transferase activity ubiquitin-dependent protein catabolic process CCR4-NOT complex regulation of megakaryocyte differentiation metal ion binding protein autoubiquitination uc009bid.1 uc009bid.2 uc009bid.3 uc009bid.4 
ENSMUST00000114996.8 Optn ENSMUST00000114996.8 optineurin, transcript variant 2 (from RefSeq NM_181848.5) A2ASP3 ENSMUST00000114996.1 ENSMUST00000114996.2 ENSMUST00000114996.3 ENSMUST00000114996.4 ENSMUST00000114996.5 ENSMUST00000114996.6 ENSMUST00000114996.7 NM_181848 OPTN_MOUSE Q8K3K8 uc008ifn.1 uc008ifn.2 uc008ifn.3 Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin- coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. Self-associates (By similarity). Interacts with HD, GTF3A, TRAF3, TBK1 and MYO6. Interacts (via UBAN) with ubiquitinated TFRC. Interacts with active GTP-bound Rab8 (RAB8A and/or RAB8B). Interacts with TBC1D17. Binds to linear ubiquitin chains. Interacts with LC3 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2; OPTN phosphorylation increases the association (at least with MAP1LC3B). Interacts with RAB12; the interaction may be indirect. Interacts with TBK1; this interaction leads to the Golgi localization of TBK1 and its subsequent activation. Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction does not lead to palmitoylation of OPTN (By similarity). Interacts with CYLD (By similarity). Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and OPTN (By similarity). Cytoplasm, perinuclear region Golgi apparatus Golgi apparatus, trans-Golgi network Cytoplasmic vesicle, autophagosome Cytoplasmic vesicle Recycling endosome Note=Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3- positive cytoplasmic vesicles upon induction of autophagy (By similarity). In eye, it is expressed in anterior segment, retina, and optic nerve blood vessels (at protein level). Highly expressed in adult liver, heart and testis. Expressed from 7-day-old embryos. Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1. The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins. Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection. OPTN E59K transgenic mice exhibit profound gliosis in the retina. OPTN-deficient cells display reduced TBK1 activation, IRF3 phosphorylation, and expression of type I IFNs in response to TLR3 and TLR4 stimulation, indicating a role for OPTN in the innate immune response. TFIIIA-class transcription factor binding positive regulation of cytokine production negative regulation of receptor recycling immune system process protein binding nucleus cytoplasm endosome autophagosome Golgi apparatus trans-Golgi network cytosol autophagy Golgi organization protein C-terminus binding positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of autophagy positive regulation of gene expression vesicle-mediated transport Rab GTPase binding axon protein binding, bridging cytoplasmic vesicle polyubiquitin binding protein localization to Golgi apparatus cellular protein localization cellular response to unfolded protein identical protein binding Golgi to plasma membrane protein transport neuronal cell body negative regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process innate immune response metal ion binding perinuclear region of cytoplasm cytokine secretion defense response to Gram-negative bacterium protein homooligomerization recycling endosome parkin-mediated mitophagy in response to mitochondrial depolarization K63-linked polyubiquitin binding Golgi ribbon formation positive regulation of xenophagy positive regulation of neural precursor cell proliferation uc008ifn.1 uc008ifn.2 uc008ifn.3 
ENSMUST00000115010.9 Ucma ENSMUST00000115010.9 upper zone of growth plate and cartilage matrix associated, transcript variant 2 (from RefSeq NM_001113558.2) C9W8R6 C9W8R7 C9W8R8 C9W8R9 ENSMUST00000115010.1 ENSMUST00000115010.2 ENSMUST00000115010.3 ENSMUST00000115010.4 ENSMUST00000115010.5 ENSMUST00000115010.6 ENSMUST00000115010.7 ENSMUST00000115010.8 NM_001113558 Q14BU0 Q9D1A9 UCMA_MOUSE uc008iff.1 uc008iff.2 uc008iff.3 uc008iff.4 This gene encodes chondrocyte-specific, highly charged proteins that are abundantly expressed during the early stages of chondrogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Despite the implied role in calcification and ossification, mice lacking the encoded protein do not display significant defects in the skeletal development. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo a similar proteolytic processing to generate mature proteins. [provided by RefSeq, Aug 2015]. May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. Secreted, extracellular space, extracellular matrix [Isoform 1]: Secreted. Golgi apparatus. [Isoform 3]: Secreted. Golgi apparatus. [Isoform 2]: Cytoplasm, cytoskeleton Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. [Isoform 4]: Cytoplasm, cytoskeleton Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Ucma/GRP-F1; IsoId=Q14BU0-1; Sequence=Displayed; Name=2; Synonyms=Ucma/GRP-F2; IsoId=Q14BU0-2; Sequence=VSP_035051; Name=3; Synonyms=Ucma/GRP-F3; IsoId=Q14BU0-3; Sequence=VSP_040807; Name=4; Synonyms=Ucma/GRP-F4; IsoId=Q14BU0-4; Sequence=VSP_035051, VSP_040807; Predominantly expressed in resting chondrocytes. Transiently expressed in the developing mouse skeleton between day 13.5 dpc of embryonic development and 5 months of postnatal development. Absent in undifferentiated mesenchymal cells. Isoforms 1 and 3 are significantly increased with the onset of chondrogenesis, whereas Isoforms 2 and 4 are detected at a later stage. Expression inhibited by TGFB1, and weakly inhibited by BMP2. Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation. Sulfated on one or two tyrosine residues within the tryptic peptide 121-135. Belongs to the UCMA family. molecular_function extracellular region extracellular space cytoplasm Golgi apparatus cytoskeleton aggresome extracellular matrix regulation of osteoblast differentiation negative regulation of osteoblast differentiation perinuclear region of cytoplasm uc008iff.1 uc008iff.2 uc008iff.3 uc008iff.4 
ENSMUST00000115017.8 Agbl3 ENSMUST00000115017.8 ATP/GTP binding protein-like 3, transcript variant 2 (from RefSeq NM_178630.4) Agbl3 B2RSY8 CBPC3_MOUSE Ccp3 ENSMUST00000115017.1 ENSMUST00000115017.2 ENSMUST00000115017.3 ENSMUST00000115017.4 ENSMUST00000115017.5 ENSMUST00000115017.6 ENSMUST00000115017.7 NM_178630 Q09M06 Q09M07 Q8BSW4 Q8CDP0 Q8R036 uc009bhr.1 uc009bhr.2 uc009bhr.3 uc009bhr.4 Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins (PubMed:25103237). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein (PubMed:25103237). Specifically cleaves tubulin long-side- chains, while it is not able to remove the branching point glutamate (PubMed:25103237). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK (PubMed:25103237). May catalyze the hydrolysis of aspartate from the carboxy-terminus of target proteins (PubMed:25103237). Does not show detyrosinase or deglycylase activities from the carboxy-terminus of target proteins (PubMed:25103237). Reaction=(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L- glutamate; Xref=Rhea:RHEA:60004, Rhea:RHEA-COMP:15519, Rhea:RHEA- COMP:15675, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:143623; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60005; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8CDP0-1; Sequence=Displayed; Name=2; IsoId=Q8CDP0-2; Sequence=VSP_024376, VSP_024379; Name=3; IsoId=Q8CDP0-3; Sequence=VSP_024376; Name=4; IsoId=Q8CDP0-4; Sequence=VSP_024376, VSP_024377, VSP_024378; Name=5; IsoId=Q8CDP0-5; Sequence=VSP_024374, VSP_024375; Widely expressed. Expressed abundantly in tissues with m otile cilia such as testis, lung and trachea. Abundantly expressed in pituitary and kidney, moderately expressed in brain, eye, fat, pancreas, stomach, and adrenal. Up-regulated during ciliogenesis. AGBL2 and AGBL3 double knockout mutant mice are viable and display no obvious phenotypic alterations. Show an increase in tubulin and MYLK polyglutamylation in sperm. Belongs to the peptidase M14 family. carboxypeptidase activity metallocarboxypeptidase activity cellular_component cytoplasm cytosol proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity protein side chain deglutamylation metal ion binding uc009bhr.1 uc009bhr.2 uc009bhr.3 uc009bhr.4 
ENSMUST00000115026.8 Cald1 ENSMUST00000115026.8 caldesmon 1, transcript variant 1 (from RefSeq NM_001347100.1) Cald1 E9QA16 E9QA16_MOUSE ENSMUST00000115026.1 ENSMUST00000115026.2 ENSMUST00000115026.3 ENSMUST00000115026.4 ENSMUST00000115026.5 ENSMUST00000115026.6 ENSMUST00000115026.7 NM_001347100 uc291dlh.1 uc291dlh.2 actin binding calmodulin binding actin filament plasma membrane muscle contraction regulation of smooth muscle contraction postsynaptic density actin cytoskeleton membrane myosin binding dendrite actin cap positive regulation of protein binding neuronal cell body dendritic spine intracellular membrane-bounded organelle actin filament bundle assembly uc291dlh.1 uc291dlh.2 
ENSMUST00000115028.11 Itgb5 ENSMUST00000115028.11 integrin beta 5, transcript variant 1 (from RefSeq NM_001145884.2) ENSMUST00000115028.1 ENSMUST00000115028.10 ENSMUST00000115028.2 ENSMUST00000115028.3 ENSMUST00000115028.4 ENSMUST00000115028.5 ENSMUST00000115028.6 ENSMUST00000115028.7 ENSMUST00000115028.8 ENSMUST00000115028.9 Itgb5 NM_001145884 Q6PE70 Q6PE70_MOUSE uc007zao.1 uc007zao.2 uc007zao.3 Cell membrane ingle-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the integrin beta chain family. cell adhesion integrin-mediated signaling pathway integrin complex membrane integral component of membrane signaling receptor activity uc007zao.1 uc007zao.2 uc007zao.3 
ENSMUST00000115032.8 Arid5a ENSMUST00000115032.8 AT-rich interaction domain 5A, transcript variant 2 (from RefSeq NM_001172206.1) ARI5A_MOUSE ENSMUST00000115032.1 ENSMUST00000115032.2 ENSMUST00000115032.3 ENSMUST00000115032.4 ENSMUST00000115032.5 ENSMUST00000115032.6 ENSMUST00000115032.7 NM_001172206 Q3TZS4 Q3U0F0 Q3U0S2 Q3U108 Q3UDA3 Q3UDZ6 Q8BI45 Q8BYB5 Q8R2W1 uc007apv.1 uc007apv.2 uc007apv.3 uc007apv.4 DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes (By similarity). May positively regulate chondrocyte- specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (PubMed:21346191). Can repress ESR1- mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (By similarity). As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells (PubMed:23676272, PubMed:27022145). In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling (PubMed:24782182). Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (PubMed:27671645). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (PubMed:29244194). Interacts with SOX9 (PubMed:21346191). Interacts with ESR1 (By similarity). Interacts with RORC (PubMed:24782182). Q3U108; P48436: SOX9; Xeno; NbExp=3; IntAct=EBI-14022639, EBI-3920028; Nucleus Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q3U108-1; Sequence=Displayed; Name=2; IsoId=Q3U108-2; Sequence=VSP_025839; Name=3; IsoId=Q3U108-3; Sequence=VSP_025840, VSP_025842; Name=4; IsoId=Q3U108-4; Sequence=VSP_025841; Name=5; IsoId=Q3U108-5; Sequence=VSP_025838; Expressed in T cells (at protein level) (PubMed:29244194). Expressed at high levels in cartilage, heart, testis and bone (PubMed:21346191). In macrophages by LPS, IL1B and IL6 (PubMed:21346191). By IL6/STAT3 signaling in T-helper Th17 cells (PubMed:24782182, PubMed:29244194). Phosphorylated by MAPK14 on serine residues involving a TLR4 signaling pathway upon lipopolysaccharide (LPS) stimulation leading to its ubiquitination and proteasomal degradation. Ubiquitinated leading to proteasomal degradation; involving WWP1 linked to MAPK14-mediated phosphorylation upon LPS stimulation. Mice are resistant to experimental autoimmune encephalomyelitis (EAE), a T-cell-mediated autoimmune model (PubMed:29244194). The expression of pro-inflammatory mediators is severely reduced in EAE (PubMed:29244194). negative regulation of transcription from RNA polymerase II promoter chondrocyte differentiation immune system process DNA binding chromatin binding transcription corepressor activity RNA binding protein binding nucleus nucleoplasm transcription factor complex nucleolus regulation of transcription from RNA polymerase II promoter transcription factor binding estrogen receptor binding positive regulation of histone acetylation RNA stem-loop binding sequence-specific DNA binding transcription regulatory region DNA binding innate immune response positive regulation of transcription from RNA polymerase II promoter retinoid X receptor binding thyroid hormone receptor binding androgen receptor binding cellular response to lipopolysaccharide cellular response to estrogen stimulus positive regulation of interferon-gamma secretion positive regulation of tumor necrosis factor secretion positive regulation of interleukin-17 secretion positive regulation of T-helper 17 type immune response positive regulation of T-helper 1 cell cytokine production positive regulation of interleukin-6 secretion uc007apv.1 uc007apv.2 uc007apv.3 uc007apv.4 
ENSMUST00000115044.8 Muc13 ENSMUST00000115044.8 mucin 13, epithelial transmembrane, transcript variant 2 (from RefSeq NM_010739.2) ENSMUST00000115044.1 ENSMUST00000115044.2 ENSMUST00000115044.3 ENSMUST00000115044.4 ENSMUST00000115044.5 ENSMUST00000115044.6 ENSMUST00000115044.7 Muc13 NM_010739 Q3V1S6 Q3V1S6_MOUSE uc007zal.1 uc007zal.2 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc007zal.1 uc007zal.2 
ENSMUST00000115050.10 Spire1 ENSMUST00000115050.10 spire type actin nucleation factor 1, transcript variant 6 (from RefSeq NR_175397.1) A0A5H1ZRL1 A0A5H1ZRL1_MOUSE ENSMUST00000115050.1 ENSMUST00000115050.2 ENSMUST00000115050.3 ENSMUST00000115050.4 ENSMUST00000115050.5 ENSMUST00000115050.6 ENSMUST00000115050.7 ENSMUST00000115050.8 ENSMUST00000115050.9 NR_175397 Spire1 uc012bej.1 uc012bej.2 uc012bej.3 uc012bej.4 Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the spire family. uc012bej.1 uc012bej.2 uc012bej.3 uc012bej.4 
ENSMUST00000115055.9 Fam107b ENSMUST00000115055.9 family with sequence similarity 107, member B, transcript variant 7 (from RefSeq NM_001418252.1) ENSMUST00000115055.1 ENSMUST00000115055.2 ENSMUST00000115055.3 ENSMUST00000115055.4 ENSMUST00000115055.5 ENSMUST00000115055.6 ENSMUST00000115055.7 ENSMUST00000115055.8 F107B_MOUSE Fam107b NM_001418252 Q3TGF2 Q9CR82 uc289sqv.1 uc289sqv.2 Expressed in the hippocampus and hypothalamus. Expressed in the pontine nuclei and reticulotegmental nucleus. Expressed in Purkinje cell and nuclear layers of the cerebelum. Expressed in the choroid plexus. Expressed in hippocampal granule neurons of the dente gyrus. Expressed in the developing brain embryo. Expressed in the mesencephalon in the tectum at 12.5 dpc and in the inferior colliculus at 16.5 dpc until birth. Expressed in the telencephalon in the ventricular zone, cortical plate, ganglionic eminence and hippocampus from 14.5 to 18.5 dpc. Expressed in the rhombencephalon in the pontine nuclei and in the external granule layer of the cerebellum at 16.5 and 18.5 dpc. Is not up-regulated in the hippocampus by acute social defeat stress or glucocorticoids stimulation. Belongs to the FAM107 family. Sequence=BAE40596.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component sensory perception of sound uc289sqv.1 uc289sqv.2 
ENSMUST00000115057.2 Dcaf12l2 ENSMUST00000115057.2 DDB1 and CUL4 associated factor 12-like 2 (from RefSeq NM_175539.3) DC122_MOUSE ENSMUST00000115057.1 NM_175539 Q8BGW4 Wdr40c uc009tbf.1 uc009tbf.2 uc009tbf.3 Belongs to the WD repeat DCAF12 family. molecular_function biological_process Cul4-RING E3 ubiquitin ligase complex uc009tbf.1 uc009tbf.2 uc009tbf.3 
ENSMUST00000115068.10 Slc37a2 ENSMUST00000115068.10 solute carrier family 37 (glycerol-3-phosphate transporter), member 2, transcript variant 2 (from RefSeq NM_020258.5) Ci2 ENSMUST00000115068.1 ENSMUST00000115068.2 ENSMUST00000115068.3 ENSMUST00000115068.4 ENSMUST00000115068.5 ENSMUST00000115068.6 ENSMUST00000115068.7 ENSMUST00000115068.8 ENSMUST00000115068.9 G6PT3_MOUSE NM_020258 Q571N8 Q6P4P0 Q8BV90 Q8C144 Q8R1Y0 Q9WU81 Slc37a2 uc009ouk.1 uc009ouk.2 uc009ouk.3 uc009ouk.4 Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. Reaction=D-glucose 6-phosphate(in) + phosphate(out) = D-glucose 6- phosphate(out) + phosphate(in); Xref=Rhea:RHEA:71535, ChEBI:CHEBI:43474, ChEBI:CHEBI:61548; Evidence=; Inhibited by vanadate but not by chlorogenic acid. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WU81-1; Sequence=Displayed; Name=2; IsoId=Q9WU81-2; Sequence=VSP_028964; Highly expressed in bone marrow derived macrophages, and weakly in spleen. Up-regulated by cAMP in macrophages. Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. Sequence=BAD90337.1; Type=Frameshift; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane integral component of plasma membrane glycerol-3-phosphate metabolic process glycerophosphate shuttle carbohydrate transport glycerol-3-phosphate transmembrane transporter activity antiporter activity glucose-6-phosphate transport glycerol-3-phosphate transport membrane integral component of membrane transmembrane transporter activity integral component of endoplasmic reticulum membrane phosphate ion transmembrane transport transmembrane transport glucose 6-phosphate:inorganic phosphate antiporter activity uc009ouk.1 uc009ouk.2 uc009ouk.3 uc009ouk.4 
ENSMUST00000115073.9 Stag2 ENSMUST00000115073.9 STAG2 cohesin complex component, transcript variant 3 (from RefSeq NM_001290713.2) A2AFF6 A2AFF6_MOUSE ENSMUST00000115073.1 ENSMUST00000115073.2 ENSMUST00000115073.3 ENSMUST00000115073.4 ENSMUST00000115073.5 ENSMUST00000115073.6 ENSMUST00000115073.7 ENSMUST00000115073.8 NM_001290713 Stag2 uc292nxz.1 uc292nxz.2 Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein. Nucleus Chromosome Chromosome, centromere Belongs to the SCC3 family. chromatin sister chromatid cohesion cohesin complex nuclear matrix mitotic spindle pole regulation of mitotic spindle assembly uc292nxz.1 uc292nxz.2 
ENSMUST00000115077.8 Abcb8 ENSMUST00000115077.8 ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane (By similarity). Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (By similarity). Plays a role in mitochondrial iron transport (PubMed:22375032). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (PubMed:22375032). (from UniProt Q9CXJ4) Abcb8 BC015301 ENSMUST00000115077.1 ENSMUST00000115077.2 ENSMUST00000115077.3 ENSMUST00000115077.4 ENSMUST00000115077.5 ENSMUST00000115077.6 ENSMUST00000115077.7 MITOS_MOUSE Mitosur Q8C695 Q8C7W4 Q9CXJ4 uc008wrh.1 uc008wrh.2 uc008wrh.3 ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane (By similarity). Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (By similarity). Plays a role in mitochondrial iron transport (PubMed:22375032). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (PubMed:22375032). Channel activity inhibited by ATP via ABCB8/MITOSUR subunit. The mitochondrial potassium channel (mitoK(ATP)) is composed of 4 subunits of CCDC51/MITOK and 4 subunits of ABCB8/MITOSUR (By similarity). Interacts with PAAT (By similarity). Interacts with NRP1; NRP1 regulates ABCB8/MITOSUR protein levels in mitochondria (By similarity). Mitochondrion inner membrane ; Multi-pass membrane protein Conditional knockout in heart results in a severe cardiomyopathy and mitochondrial iron accumulation. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. nucleotide binding ATP binding nucleus nucleolus mitochondrion mitochondrial inner membrane membrane integral component of membrane ATPase activity mitochondrial membrane ATPase activity, coupled to transmembrane movement of substances transmembrane transport uc008wrh.1 uc008wrh.2 uc008wrh.3 
ENSMUST00000115089.2 Acbd7 ENSMUST00000115089.2 acyl-Coenzyme A binding domain containing 7 (from RefSeq NM_030063.2) A2AJG1 ACBD7_MOUSE ENSMUST00000115089.1 NM_030063 Q9D258 uc008idt.1 uc008idt.2 uc008idt.3 uc008idt.4 Binds medium- and long-chain acyl-CoA esters. Belongs to the ACBD7 family. fatty-acyl-CoA binding molecular_function cellular_component biological_process lipid binding uc008idt.1 uc008idt.2 uc008idt.3 uc008idt.4 
ENSMUST00000115094.8 Xiap ENSMUST00000115094.8 X-linked inhibitor of apoptosis, transcript variant 3 (from RefSeq NM_009688.3) A2BGY6 Aipa Api3 Birc4 ENSMUST00000115094.1 ENSMUST00000115094.2 ENSMUST00000115094.3 ENSMUST00000115094.4 ENSMUST00000115094.5 ENSMUST00000115094.6 ENSMUST00000115094.7 Miha NM_009688 O08865 Q60989 XIAP_MOUSE Xiap uc009tav.1 uc009tav.2 uc009tav.3 uc009tav.4 The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family of proteins. While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis (By similarity). Acts as a direct caspase inhibitor (By similarity). Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry (By similarity). Inhibits apoptosis in intestinal crypt cells, its activity is mitigated via its interaction with SEPTIN4 isoform ARTS (PubMed:30389919). Inactivates CASP9 by keeping it in a monomeric, inactive state (By similarity). Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin (PubMed:18761086, PubMed:19473982). Acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF- kappa-B and MAP kinases signaling (PubMed:29452636). 'Lys-63'-linked polyubiquitination of RIPK2 also promotes recruitment of the LUBAC complex to RIPK2 (By similarity). Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation (By similarity). Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation (By similarity). Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation (By similarity). Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation (By similarity). Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation (By similarity). Ubiquitinates and therefore mediates the proteasomal degradation of BCL2 in response to apoptosis (By similarity). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner (By similarity). Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8 (By similarity). Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES (By similarity). Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program (By similarity). Positive regulator of dermal wound repair, potentially via its interaction with SEPTIN4 (PubMed:23788729). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Monomer, and homodimer. Interacts (via BIR3 domain) with DIABLO/SMAC; the interaction inhibits apoptotic suppressor activity (By similarity). Interacts with HTRA2/PRSS25; the interaction inhibits apoptotic suppressor activity. Interacts with TAB1/MAP3K7IP1 and AIFM1. Interaction with DIABLO/SMAC hinders binding of TAB1/MAP3K7IP1 and AIFM1. Interacts with TCF25 and COMMD1. Interacts (via BIR3 domain) with SEPTIN4 (PubMed:30389919). Interacts with RIP1, RIP2, RIP3, RIP4, CCS and USP19. Interacts (via BIR 2 domain and BIR 3 domain) with HAX1 (via C-terminus) and this interaction blocks ubiquitination of XIAP/BIRC4. Interacts with the monomeric form of BIRC5/survivin (By similarity). Interacts with TLE3 and TCF7L2/TCF4 (By similarity). Interacts (via BIR 3 and RING domains) with PDCL3 (By similarity). Q60989; P53702: Hccs; NbExp=5; IntAct=EBI-517478, EBI-8579982; Q60989; Q9JIY5: Htra2; NbExp=2; IntAct=EBI-517478, EBI-2365838; Cytoplasm Nucleus Note=TLE3 promotes its nuclear localization. Expressed in small intestine crypts (at protein level) (PubMed:30389919). Expressed in bulge hair follicle stem cells, sebaceous glands and dermal papillae (at protein level) (PubMed:23788729). The first BIR domain is involved in interaction with TAB1/MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit caspase-3 and caspase-7, while the third BIR is involved in caspase-9 inhibition. The interactions with DIABLO/SMAC and HTRA2/PRSS25 are mediated by the second and third BIR domains (By similarity). S-Nitrosylation down-regulates its E3 ubiquitin-protein ligase activity. Autoubiquitinated. In knockout mice decreased number of Paneth cells in intestinal crypts, decreased proliferation and increased goblet cells in the intestinal villi (PubMed:30389919). Increased weight loss following intestinal wounding, increased inflammation, distorted tissue architecture, muscle thickening and greater crypt loss (PubMed:30389919). Delayed dermal wound repair (PubMed:23788729). SEPTIN4 and XIAP double knockout mice show delayed dermal wound repair and hair follicle regeneration, via increased apoptosis of hair follicle stem cells (PubMed:23788729). Belongs to the IAP family. protease binding ubiquitin-protein transferase activity protein binding nucleus cytoplasm cytosol apoptotic process Wnt signaling pathway protein ubiquitination transferase activity positive regulation of protein ubiquitination macromolecular complex identical protein binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of neuron apoptotic process metal ion binding perinuclear region of cytoplasm neuron apoptotic process ubiquitin protein ligase activity positive regulation of canonical Wnt signaling pathway scaffold protein binding positive regulation of protein linear polyubiquitination inhibition of cysteine-type endopeptidase activity involved in apoptotic process uc009tav.1 uc009tav.2 uc009tav.3 uc009tav.4 
ENSMUST00000115096.4 Plxna4 ENSMUST00000115096.4 plexin A4 (from RefSeq NM_175750.3) E9QN64 ENSMUST00000115096.1 ENSMUST00000115096.2 ENSMUST00000115096.3 Kiaa1550 NM_175750 PLXA4_MOUSE Q5DTW8 Q80UG2 Q8BKK9 uc009bgm.1 uc009bgm.2 uc009bgm.3 uc009bgm.4 uc009bgm.5 uc009bgm.6 Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with NRP1 and NRP2. Q80UG2; O35464: Sema6a; NbExp=3; IntAct=EBI-8057809, EBI-8057848; Cell membrane ; Single-pass type I membrane protein Expressed in the developing nervous system. Widely expressed in both the central and peripheral nervous systems. Expressed in the peripheral ganglia, somatosensory, olfactory, visual, auditory and equilibrium systems. No visible phenotype. Mice exhibit defasciculation of the facial branchiomotor nerve and of the ophthalmic branch of the trigeminus, with variable severity. In mice lacking both Plxna3 and Plxna4, migrating neurons do not show the normal response to Sema3A and Sema3F and do not migrate away from these semaphorins (in vitro). Belongs to the plexin family. Sequence=BAC56599.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; semaphorin receptor complex protein binding plasma membrane integral component of plasma membrane negative regulation of cell adhesion signal transduction nervous system development axon guidance motor neuron axon guidance regulation of cell shape membrane integral component of membrane semaphorin receptor activity cranial nerve morphogenesis facial nerve morphogenesis facial nerve structural organization glossopharyngeal nerve morphogenesis trigeminal nerve morphogenesis trigeminal nerve structural organization vagus nerve morphogenesis postganglionic parasympathetic fiber development branchiomotor neuron axon guidance chemorepulsion of branchiomotor axon anterior commissure morphogenesis regulation of cell migration regulation of GTPase activity sympathetic nervous system development neuron projection morphogenesis regulation of axon extension involved in axon guidance positive regulation of axonogenesis regulation of negative chemotaxis semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway involved in axon guidance uc009bgm.1 uc009bgm.2 uc009bgm.3 uc009bgm.4 uc009bgm.5 uc009bgm.6 
ENSMUST00000115097.8 Oacyl ENSMUST00000115097.8 O-acyltransferase like (from RefSeq NM_177028.3) B9EJ12 E9Q6M1 ENSMUST00000115097.1 ENSMUST00000115097.2 ENSMUST00000115097.3 ENSMUST00000115097.4 ENSMUST00000115097.5 ENSMUST00000115097.6 ENSMUST00000115097.7 NM_177028 OACYL_MOUSE Oacyl Q8BMK8 Q8BML2 uc008ffg.1 uc008ffg.2 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BML2-1; Sequence=Displayed; Name=2; IsoId=Q8BML2-2; Sequence=VSP_058597; Belongs to the acyltransferase 3 family. molecular_function cellular_component biological_process membrane integral component of membrane transferase activity, transferring acyl groups other than amino-acyl groups uc008ffg.1 uc008ffg.2 
ENSMUST00000115099.9 Fam171a1 ENSMUST00000115099.9 family with sequence similarity 171, member A1, transcript variant 1 (from RefSeq NM_001081161.2) A2ATK9 A2ATK9_MOUSE ENSMUST00000115099.1 ENSMUST00000115099.2 ENSMUST00000115099.3 ENSMUST00000115099.4 ENSMUST00000115099.5 ENSMUST00000115099.6 ENSMUST00000115099.7 ENSMUST00000115099.8 Fam171a1 NM_001081161 uc008idn.1 uc008idn.2 uc008idn.3 Membrane ; Single- pass type I membrane protein Belongs to the FAM171 family. molecular_function plasma membrane regulation of cell shape membrane integral component of membrane stress fiber assembly uc008idn.1 uc008idn.2 uc008idn.3 
ENSMUST00000115100.9 Iqcg ENSMUST00000115100.9 IQ motif containing G (from RefSeq NM_178378.3) DRC9_MOUSE Drc9 ENSMUST00000115100.1 ENSMUST00000115100.2 ENSMUST00000115100.3 ENSMUST00000115100.4 ENSMUST00000115100.5 ENSMUST00000115100.6 ENSMUST00000115100.7 ENSMUST00000115100.8 NM_178378 Q80W32 uc007yzt.1 uc007yzt.2 uc007yzt.3 uc007yzt.4 Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (By similarity). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility (PubMed:24362311, PubMed:24849454). Component of the nexin-dynein regulatory complex (N-DRC) (By similarity). Interacts (via IQ domain) with CALM when calcium levels are low. Does not interact with CALM in the presence of Ca(2+) (PubMed:24849454). Interacts with the HSP70 proteins HSPA1L and HSPA8 (By similarity). May form a complex with CAMK4 and HSP70 (Probable). Cytoplasm Cell projection, cilium, flagellum Cell projection, cilium Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, flagellum axoneme Note=First detected in the cytoplasm of pachytene spermatocytes. Colocalizes with alpha- tubulin at the manchette in developing spermatids. Detected in the flagellum of mature testicular spermatozoa, and in the flagellum and post-acrosomal region of the head of epididymal spermatozoa. Detected in cilia in trachea and oviduct. Expressed in the testes (at protein level) (PubMed:24362311, PubMed:24849454, PubMed:35547804). Also detected in oviduct (at protein level) (PubMed:24849454). Also detected in the trachea (PubMed:24849454). First detected in testis 17 days after birth when pachytene spermatocytes are seen in testes. Expression remains high during the first three weeks after birth and in adults (at protein level). The IQ domain mediates interaction with calmodulin when cellular Ca(2+) levels are low. No obvious phenotype, except complete male sterility (PubMed:24362311, PubMed:24849454). Female fertility is not altered (PubMed:24849454). Early spermiogenesis defective 12d (esgd12d) is caused by mutations disrupting this gene. Affected male mice display complete loss of fertility; their sperm cells lack tails and are nonmotile. Belongs to the DRC9 family. manchette calmodulin binding cytoplasm cytosol cytoskeleton cilium spermatogenesis spermatid development sperm axoneme assembly cell differentiation Hsp70 protein binding motile cilium sperm flagellum cell projection cilium organization uc007yzt.1 uc007yzt.2 uc007yzt.3 uc007yzt.4 
ENSMUST00000115109.2 Hycc1 ENSMUST00000115109.2 hyccin PI4KA lipid kinase complex subunit 1, transcript variant 5 (from RefSeq NM_001425740.1) D3Z481 Drctnnb1a ENSMUST00000115109.1 Fam126a HYCCI_MOUSE NM_001425740 Q3TTP7 Q6P9N1 Q99NC4 uc290tpg.1 uc290tpg.2 Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta-catenin/Lef signaling pathway. Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2). Interacts with TTC7 (TTC7A or TTC7B), interaction is direct. Cytoplasm, cytosol Cell membrane Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P9N1-1; Sequence=Displayed; Name=2; IsoId=Q6P9N1-2; Sequence=VSP_058131, VSP_058132; Name=3; IsoId=Q6P9N1-3; Sequence=VSP_058130, VSP_058133; Predominantly expressed in the central nervous system, where it is found in neurons but not in myelinating cells. Lower abundance is observed in peripheral neurons, where it is detectable only at early postnatal ages (PubMed:22461884). Expressed in both oligodendrocytes and neurons (PubMed:26571211). Down-regulated by beta-catenin. No visible phenotype. Lysates from total brain and optic nerve (a pure white matter tract) display a selective decrease of Ttc7a and Efr3a protein levels. Belongs to the Hyccin family. molecular_function cytoplasm cytosol plasma membrane membrane myelination neuron projection phosphatidylinositol phosphorylation protein localization to plasma membrane uc290tpg.1 uc290tpg.2 
ENSMUST00000115110.5 Hyls1 ENSMUST00000115110.5 HYLS1, centriolar and ciliogenesis associated (from RefSeq NM_029762.1) A0A0R4J1K7 A0A0R4J1K7_MOUSE ENSMUST00000115110.1 ENSMUST00000115110.2 ENSMUST00000115110.3 ENSMUST00000115110.4 Hyls1 NM_029762 uc009oti.1 uc009oti.2 uc009oti.3 uc009oti.4 Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Belongs to the HYLS1 family. nucleus cytoplasm centrosome cytosol plasma membrane uc009oti.1 uc009oti.2 uc009oti.3 uc009oti.4 
ENSMUST00000115116.8 Muc20 ENSMUST00000115116.8 mucin 20, transcript variant 1 (from RefSeq NM_001145874.1) E9PUF1 E9PUF1_MOUSE ENSMUST00000115116.1 ENSMUST00000115116.2 ENSMUST00000115116.3 ENSMUST00000115116.4 ENSMUST00000115116.5 ENSMUST00000115116.6 ENSMUST00000115116.7 Muc20 NM_001145874 uc012aer.1 uc012aer.2 hepatocyte growth factor receptor signaling pathway uc012aer.1 uc012aer.2 
ENSMUST00000115134.2 Atp1b4 ENSMUST00000115134.2 ATPase Na+/K+ transporting, beta 4 polypeptide, transcript variant 2 (from RefSeq NM_001290389.1) AT1B4_MOUSE ENSMUST00000115134.1 NM_001290389 Q543D0 Q99ME5 Q99ME6 uc009szu.1 uc009szu.2 uc009szu.3 uc009szu.4 May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity). Associates with a SMAD7-transcriptional complex. Interacts with TOR1AIP1. Does not associate with known Na,K-ATPase alpha-subunits (By similarity). Interacts with SNW1. Nucleus inner membrane ; Single-pass type II membrane protein Note=Detected in nuclear envelops. Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=Q99ME6-1; Sequence=Displayed; Name=B; IsoId=Q99ME6-2; Sequence=VSP_000352; Expressed in skeletal muscle (at protein level). Expressed during postnatal development in skeletal muscle and heart. Expressed in embryo 15.5 dpc, onward. Belongs to the X(+)/potassium ATPases subunit beta family. chromatin protein binding nucleus nuclear envelope nuclear inner membrane sodium:potassium-exchanging ATPase complex regulation of transcription, DNA-templated membrane integral component of membrane monovalent inorganic cation transport uc009szu.1 uc009szu.2 uc009szu.3 uc009szu.4 
ENSMUST00000115148.9 Kirrel3 ENSMUST00000115148.9 kirre like nephrin family adhesion molecule 3, transcript variant B (from RefSeq NM_026324.3) ENSMUST00000115148.1 ENSMUST00000115148.2 ENSMUST00000115148.3 ENSMUST00000115148.4 ENSMUST00000115148.5 ENSMUST00000115148.6 ENSMUST00000115148.7 ENSMUST00000115148.8 KIRR3_MOUSE Kiaa1867 NM_026324 Neph2 Q6P555 Q810H3 Q8BGQ5 Q8BR86 Q8BRS8 uc292foy.1 uc292foy.2 Synaptic adhesion molecule required for the formation of target-specific synapses (PubMed:23637329, PubMed:26575286). Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation (PubMed:26575286). Required for the coalescence of vomeronasal sensory neuron axons (PubMed:23637329). May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells (PubMed:12665856). Homodimer; mediates homophilic interactions to promote cell adhesion (PubMed:26575286). Interacts with NPHS1; forms heterodimers with NPHS1 (PubMed:15843475, PubMed:18752272). Interacts with NPHS2/podocin (via the C-terminus) (By similarity). Interacts with CASK. Interacts (via extracellular region) with MAP1B. Interacts (via extracellular region) with MYO16. Interacts (via intracellular region) with ATP1B1. Interacts (via intracellular region) with SHMT2. Interacts (via intracellular region) with UFC1 (By similarity). Cell membrane ; Single-pass type I membrane protein Cell projection, axon Cell projection, dendrite [Processed kin of IRRE-like protein 3]: Secreted Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BR86-1; Sequence=Displayed; Name=2; IsoId=Q8BR86-2; Sequence=VSP_011816, VSP_011818; Name=3; IsoId=Q8BR86-3; Sequence=VSP_011817, VSP_011819, VSP_011820; Name=4; IsoId=Q8BR86-4; Sequence=VSP_011817; Expressed mainly in adult brain, bone marrow and stromal cells (PubMed:12665856). Expressed in diverse regions of the brain, including the cortex, hippocampus, striatum, olfactory bulb and cerebellum (PubMed:15908127, PubMed:26283919). In brain, expressed in pontine nucleus neurons (at protein level) (PubMed:21241806). In hippocampus, produced in both the dentate granule neurons and the GABAergic neurons, but not the CA3 neurons (PubMed:26575286). Expressed in subpopulations of vomeronasal sensory neurons (PubMed:23637329). Expressed in a subset of neurons in dorsal root ganglia (PubMed:18752272). At embryonic day 11.5, it is expressed in the differentiating zones of various regions, such as the caudate-putamen, the geniculate body, the thalamus, the amygdala and the brainstem. This expression persists in the adult, although expression is lower. After birth, highly expressed in the glomerular and mitral layers of the olfactory bulb, the cortical plate of the neocortex, the cochlear nucleus, and the molecular and granule cell layers of the cerebellum. In the hippocampus, expression is first observed in the dentate gyrus at postnatal day 7. Undergoes proteolysis by a metalloprotease and gives rise to a soluble form. Mice are viable and their size is normal. Mice show defects of the accessory olfactory system characterized by disorganization of the glomerular layer of the posterior accessory olfactory bulb and formation of fewer, larger glomeruli. Mice display a loss of male-male aggression in a resident-intruder assay (PubMed:23637329). Mice display moderate hyperactivity in a familiar, but not novel, environment and defective novel object recognition with normal performances in Morris water maze spatial learning and memory, contextual fear conditioning and extinction, and pattern separation tests (PubMed:26283919). Young mutant mice form fewer synapse-forming structures between dentate granule neurons and GABAergic neurons than normal mice, while the synapses that connect dentate granule neurons to CA3 neurons form normally. This may affect the balance of activity across the two types of dentate granule synapses and the CA3 neurons, leading to hyperactivity (PubMed:26575286). Belongs to the immunoglobulin superfamily. neuron migration inter-male aggressive behavior protein binding extracellular region plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly membrane integral component of membrane principal sensory nucleus of trigeminal nerve development hippocampus development hemopoiesis PDZ domain binding axon dendrite cell projection dendritic shaft neuron projection morphogenesis glomerulus morphogenesis uc292foy.1 uc292foy.2 
ENSMUST00000115149.3 Tm4sf19 ENSMUST00000115149.3 transmembrane 4 L six family member 19 (from RefSeq NM_001160402.1) E9Q9H8 E9Q9H8_MOUSE ENSMUST00000115149.1 ENSMUST00000115149.2 NM_001160402 Tm4sf19 uc012ael.1 uc012ael.2 Membrane ; Multi- pass membrane protein Belongs to the L6 tetraspanin family. molecular_function biological_process membrane integral component of membrane uc012ael.1 uc012ael.2 
ENSMUST00000115150.4 Rhox10 ENSMUST00000115150.4 reproductive homeobox 10 (from RefSeq NM_001024850.2) ENSMUST00000115150.1 ENSMUST00000115150.2 ENSMUST00000115150.3 NM_001024850 Q4TU83 Q4TU83_MOUSE Rhox10 uc009szl.1 uc009szl.2 uc009szl.3 Nucleus RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding nucleus regulation of transcription from RNA polymerase II promoter uc009szl.1 uc009szl.2 uc009szl.3 
ENSMUST00000115151.5 Ubxn7 ENSMUST00000115151.5 UBX domain protein 7, transcript variant 1 (from RefSeq NM_177633.5) ENSMUST00000115151.1 ENSMUST00000115151.2 ENSMUST00000115151.3 ENSMUST00000115151.4 G5E8R8 G5E8R8_MOUSE NM_177633 Ubxn7 uc007yyr.1 uc007yyr.2 uc007yyr.3 uc007yyr.4 nucleoplasm transcription factor binding nuclear body ubiquitin protein ligase binding VCP-NPL4-UFD1 AAA ATPase complex ubiquitin binding uc007yyr.1 uc007yyr.2 uc007yyr.3 uc007yyr.4 
ENSMUST00000115156.2 Rhox7b ENSMUST00000115156.2 Nucleus (from UniProt A6PW38) A6PW38 A6PW38_MOUSE ENSMUST00000115156.1 Rhox7b uc292nuv.1 uc292nuv.2 Nucleus DNA binding cellular_component nucleus biological_process uc292nuv.1 uc292nuv.2 
ENSMUST00000115160.10 Tmem209 ENSMUST00000115160.10 transmembrane protein 209, transcript variant 1 (from RefSeq NM_178625.4) ENSMUST00000115160.1 ENSMUST00000115160.2 ENSMUST00000115160.3 ENSMUST00000115160.4 ENSMUST00000115160.5 ENSMUST00000115160.6 ENSMUST00000115160.7 ENSMUST00000115160.8 ENSMUST00000115160.9 NM_178625 Q80WQ3 Q8BP02 Q8BRG8 Q8C202 Q8CDY5 TM209_MOUSE uc009bfj.1 uc009bfj.2 uc009bfj.3 uc009bfj.4 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BRG8-1; Sequence=Displayed; Name=2; IsoId=Q8BRG8-2; Sequence=VSP_033284; Name=3; IsoId=Q8BRG8-3; Sequence=VSP_033285, VSP_033286; Sequence=BAC41016.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc009bfj.1 uc009bfj.2 uc009bfj.3 uc009bfj.4 
ENSMUST00000115162.2 Rhox2h ENSMUST00000115162.2 reproductive homeobox 2H (from RefSeq NM_001100465.1) ENSMUST00000115162.1 K7N6P1 K7N6P1_MOUSE NM_001100465 Rhox2h uc009szf.1 uc009szf.2 Nucleus DNA binding cellular_component nucleus biological_process uc009szf.1 uc009szf.2 
ENSMUST00000115166.3 Rhox4g ENSMUST00000115166.3 reproductive homeobox 4G (from RefSeq NM_001039698.1) ENSMUST00000115166.1 ENSMUST00000115166.2 NM_001039698 Q2MDF7 Q2MDF7_MOUSE Rhox4.7 Rhox4g uc009sze.1 uc009sze.2 uc009sze.3 Nucleus DNA binding cellular_component nucleus biological_process uc009sze.1 uc009sze.2 uc009sze.3 
ENSMUST00000115168.9 Cep19 ENSMUST00000115168.9 centrosomal protein 19, transcript variant 1 (from RefSeq NM_025892.4) CEP19_MOUSE ENSMUST00000115168.1 ENSMUST00000115168.2 ENSMUST00000115168.3 ENSMUST00000115168.4 ENSMUST00000115168.5 ENSMUST00000115168.6 ENSMUST00000115168.7 ENSMUST00000115168.8 NM_025892 Q9CQA8 uc007yyf.1 uc007yyf.2 uc007yyf.3 Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes. Interacts with CEP43; this interaction is required for its localization to the mother centriole. Interacts (via residues 121-150) with RABL2B. Interacts (via C-terminus) with CEP350; this interaction is required for its localization to the mother centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, cilium basal body Note=Associates with the mother centriole in early interphase. Localizes to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase. Localizes slightly apical to the subdistal appendage on the mother centriole, but below the distal appendage. Severe obesity, hyperphagia, decreased energy expenditure, impaired whole-body fat oxidation, altered hepatic insulin signaling, and impaired glucose and insulin tolerance. Spermatogenic cells and seminiferous tubules show marked degeneration. Belongs to the CEP19 family. spindle pole molecular_function cytoplasm centrosome centriole cytoskeleton cilium cell projection organization microtubule anchoring at centrosome ciliary basal body cell projection cilium assembly vesicle targeting, trans-Golgi to periciliary membrane compartment uc007yyf.1 uc007yyf.2 uc007yyf.3 
ENSMUST00000115169.4 Rhox2g ENSMUST00000115169.4 reproductive homeobox 2G (from RefSeq NM_001114153.1) ENSMUST00000115169.1 ENSMUST00000115169.2 ENSMUST00000115169.3 L7MUB9 L7MUB9_MOUSE NM_001114153 Rhox2g uc012hgi.1 uc012hgi.2 uc012hgi.3 Nucleus DNA binding cellular_component nucleus biological_process uc012hgi.1 uc012hgi.2 uc012hgi.3 
ENSMUST00000115170.3 Rhox4f ENSMUST00000115170.3 reproductive homeobox 4F (from RefSeq NM_001039696.1) ENSMUST00000115170.1 ENSMUST00000115170.2 NM_001039696 Q2MDF8 Q2MDF8_MOUSE Rhox4.6 Rhox4f Rhox4h uc009szc.1 uc009szc.2 uc009szc.3 Nucleus DNA binding cellular_component nucleus biological_process uc009szc.1 uc009szc.2 uc009szc.3 
ENSMUST00000115173.5 Rhox2f ENSMUST00000115173.5 reproductive homeobox 2F (from RefSeq NM_001085356.1) A2ANE0 A2ANE0_MOUSE ENSMUST00000115173.1 ENSMUST00000115173.2 ENSMUST00000115173.3 ENSMUST00000115173.4 NM_001085356 Rhox2f uc009sza.1 uc009sza.2 uc009sza.3 Nucleus DNA binding cellular_component nucleus biological_process uc009sza.1 uc009sza.2 uc009sza.3 
ENSMUST00000115175.4 Rhox4d ENSMUST00000115175.4 reproductive homeobox 4D (from RefSeq NM_001039695.1) ENSMUST00000115175.1 ENSMUST00000115175.2 ENSMUST00000115175.3 NM_001039695 Q2MDG0 Q2MDG0_MOUSE Rhox4.4 Rhox4d uc009syx.1 uc009syx.2 uc009syx.3 Nucleus DNA binding cellular_component nucleus biological_process uc009syx.1 uc009syx.2 uc009syx.3 
ENSMUST00000115179.4 Rhox2d ENSMUST00000115179.4 reproductive homeobox 2D (from RefSeq NM_001081669.2) ENSMUST00000115179.1 ENSMUST00000115179.2 ENSMUST00000115179.3 NM_001081669 Rhox2d W4VSN9 W4VSN9_MOUSE uc009syw.1 uc009syw.2 uc009syw.3 Nucleus DNA binding cellular_component nucleus biological_process uc009syw.1 uc009syw.2 uc009syw.3 
ENSMUST00000115181.9 Telo2 ENSMUST00000115181.9 telomere maintenance 2, transcript variant 1 (from RefSeq NM_001163661.1) ENSMUST00000115181.1 ENSMUST00000115181.2 ENSMUST00000115181.3 ENSMUST00000115181.4 ENSMUST00000115181.5 ENSMUST00000115181.6 ENSMUST00000115181.7 ENSMUST00000115181.8 Kiaa0683 NM_001163661 Q3U3J5 Q3UID7 Q3UP41 Q8BN03 Q8C1T3 Q91VQ3 Q9DC40 TELO2_MOUSE uc008azr.1 uc008azr.2 uc008azr.3 uc008azr.4 Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity). Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with ATM, ATR, MTOR, PRKDC, RUVBL2, TTI1, TTI2, SMG1 and TRRAP. Component of the mTORC1 and mTORC2 complexes. Interacts (phosphorylated form) with PIH1D1 (PubMed:24794838). Interaction with PIH1D1 mediates interaction of TELO2 with the R2TP complex composed of RUVBL1, RUVBL2, PIH1D1, and RPAP3 (By similarity). Q9DC40; Q9CQJ2: Pih1d1; NbExp=3; IntAct=EBI-1571482, EBI-11658528; Cytoplasm Membrane Nucleus Chromosome, telomere Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DC40-1; Sequence=Displayed; Name=2; IsoId=Q9DC40-2; Sequence=VSP_031207, VSP_031208, VSP_031209; Hydroxylation by PHD3 is required for a proper interaction with ATR, and activation of the ATR/CHK1/p53 pathway following DNA damage. Phosphorylated at Ser-486 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by the SCF(FBXO9) complex. Phosphorylation by CK2 only takes place when TELO2 is bound to mTORC1, not mTORC2; leading to selective ubiquitination of mTORC1- associated protein (By similarity). Ubiquitinated by the SCF(FBXO9) complex following phosphorylation by CK2 in response to growth factor deprivation, leading to its degradation by the proteasome. Only mTORC1-associated protein is ubiquitinated and degraded, leading to selective inactivation of mTORC1 to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity). Belongs to the TEL2 family. Sequence=BAE25556.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; chromosome, telomeric region nuclear chromosome, telomeric region protein binding nucleus chromosome cytoplasm cytosol telomere maintenance via telomerase membrane nuclear body protein kinase binding TORC1 complex TORC2 complex regulation of TOR signaling nuclear periphery telomeric DNA binding macromolecular complex binding protein stabilization Hsp90 protein binding binding, bridging ASTRA complex positive regulation of protein serine/threonine kinase activity positive regulation of TORC1 signaling positive regulation of TORC2 signaling uc008azr.1 uc008azr.2 uc008azr.3 uc008azr.4 
ENSMUST00000115183.2 Rhox4c ENSMUST00000115183.2 reproductive homeobox 4C (from RefSeq NM_001039689.1) ENSMUST00000115183.1 NM_001039689 Q2MDG1 Q2MDG1_MOUSE Rhox4.3 Rhox4c uc009syv.1 uc009syv.2 Nucleus DNA binding cellular_component nucleus biological_process uc009syv.1 uc009syv.2 
ENSMUST00000115188.9 Rhox3c ENSMUST00000115188.9 Nucleus (from UniProt A2AWM0) A2AWM0 A2AWM0_MOUSE BC087875 ENSMUST00000115188.1 ENSMUST00000115188.2 ENSMUST00000115188.3 ENSMUST00000115188.4 ENSMUST00000115188.5 ENSMUST00000115188.6 ENSMUST00000115188.7 ENSMUST00000115188.8 F7BEY6 Rhox3c uc012hfz.1 uc012hfz.2 uc012hfz.3 uc012hfz.4 Nucleus DNA binding cellular_component nucleus biological_process uc012hfz.1 uc012hfz.2 uc012hfz.3 uc012hfz.4 
ENSMUST00000115190.11 Rhox2c ENSMUST00000115190.11 reproductive homeobox 2C (from RefSeq NM_001099318.1) A2AWL9 A2AWL9_MOUSE ENSMUST00000115190.1 ENSMUST00000115190.10 ENSMUST00000115190.2 ENSMUST00000115190.3 ENSMUST00000115190.4 ENSMUST00000115190.5 ENSMUST00000115190.6 ENSMUST00000115190.7 ENSMUST00000115190.8 ENSMUST00000115190.9 NM_001099318 Rhox2c uc009syt.1 uc009syt.2 uc009syt.3 Nucleus DNA binding cellular_component nucleus biological_process uc009syt.1 uc009syt.2 uc009syt.3 
ENSMUST00000115191.7 Rhox2b ENSMUST00000115191.7 reproductive homeobox 2B (from RefSeq NM_001099316.1) A2A447 A2A447_MOUSE D3Z3D1 D3Z3R8 ENSMUST00000115191.1 ENSMUST00000115191.2 ENSMUST00000115191.3 ENSMUST00000115191.4 ENSMUST00000115191.5 ENSMUST00000115191.6 NM_001099316 Rhox2b Rhox2d uc009syq.1 uc009syq.2 uc009syq.3 Nucleus DNA binding cellular_component nucleus biological_process uc009syq.1 uc009syq.2 uc009syq.3 
ENSMUST00000115194.5 Rhox4a ENSMUST00000115194.5 reproductive homeobox 4A (from RefSeq NM_001039688.3) ENSMUST00000115194.1 ENSMUST00000115194.2 ENSMUST00000115194.3 ENSMUST00000115194.4 NM_001039688 Q9D3I8 Q9D3I8_MOUSE Rhox4.1 Rhox4a Rhox4a2 uc009syp.1 uc009syp.2 uc009syp.3 uc009syp.4 Nucleus molecular_function DNA binding cellular_component nucleus biological_process uc009syp.1 uc009syp.2 uc009syp.3 uc009syp.4 
ENSMUST00000115198.10 Rhox3e ENSMUST00000115198.10 Nucleus (from UniProt Q4TU90) DQ058640 E9Q4C8 ENSMUST00000115198.1 ENSMUST00000115198.2 ENSMUST00000115198.3 ENSMUST00000115198.4 ENSMUST00000115198.5 ENSMUST00000115198.6 ENSMUST00000115198.7 ENSMUST00000115198.8 ENSMUST00000115198.9 F6PYZ5 Q4TU90 Q4TU90_MOUSE Rhox3a Rhox3a2 Rhox3e uc012hge.1 uc012hge.2 uc012hge.3 Nucleus negative regulation of transcription from RNA polymerase II promoter molecular_function DNA binding cellular_component nucleus biological_process uc012hge.1 uc012hge.2 uc012hge.3 
ENSMUST00000115201.8 Dlg1 ENSMUST00000115201.8 discs large MAGUK scaffold protein 1, transcript variant 8 (from RefSeq NM_001357282.1) Dlg1 E9Q9H0 E9Q9H0_MOUSE ENSMUST00000115201.1 ENSMUST00000115201.2 ENSMUST00000115201.3 ENSMUST00000115201.4 ENSMUST00000115201.5 ENSMUST00000115201.6 ENSMUST00000115201.7 NM_001357282 uc289eak.1 uc289eak.2 Belongs to the MAGUK family. uc289eak.1 uc289eak.2 
ENSMUST00000115203.10 Rhox3a ENSMUST00000115203.10 reproductive homeobox 3A (from RefSeq NM_194063.3) E9Q4C8 ENSMUST00000115203.1 ENSMUST00000115203.2 ENSMUST00000115203.3 ENSMUST00000115203.4 ENSMUST00000115203.5 ENSMUST00000115203.6 ENSMUST00000115203.7 ENSMUST00000115203.8 ENSMUST00000115203.9 F6PYZ5 NM_194063 Q4TU90 Q4TU90_MOUSE Rhox3a Rhox3a2 Rhox3e uc009syo.1 uc009syo.2 uc009syo.3 uc009syo.4 Nucleus negative regulation of transcription from RNA polymerase II promoter molecular_function DNA binding cellular_component nucleus biological_process uc009syo.1 uc009syo.2 uc009syo.3 uc009syo.4 
ENSMUST00000115206.8 Nrf1 ENSMUST00000115206.8 nuclear respiratory factor 1, transcript variant 23 (from RefSeq NM_001410233.1) ENSMUST00000115206.1 ENSMUST00000115206.2 ENSMUST00000115206.3 ENSMUST00000115206.4 ENSMUST00000115206.5 ENSMUST00000115206.6 ENSMUST00000115206.7 NM_001410233 Nrf1 Q99K73 Q99K73_MOUSE uc009bet.1 uc009bet.2 uc009bet.3 Nucleus Belongs to the NRF1/Ewg family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol regulation of transcription from RNA polymerase II promoter protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter uc009bet.1 uc009bet.2 uc009bet.3 
ENSMUST00000115210.2 Rhox1 ENSMUST00000115210.2 reproductive homeobox 1 (from RefSeq NM_001025084.2) B1APN4 B1APN4_MOUSE ENSMUST00000115210.1 NM_001025084 Rhox1 uc009syl.1 uc009syl.2 uc009syl.3 Nucleus DNA binding cellular_component nucleus biological_process uc009syl.1 uc009syl.2 uc009syl.3 
ENSMUST00000115231.4 Rpl39 ENSMUST00000115231.4 ribosomal protein L39 (from RefSeq NM_026055.3) ENSMUST00000115231.1 ENSMUST00000115231.2 ENSMUST00000115231.3 NM_026055 Q505A8 Q505A8_MOUSE Rpl39 uc009syc.1 uc009syc.2 uc009syc.3 uc009syc.4 Belongs to the eukaryotic ribosomal protein eL39 family. cytoplasmic translation innate immune response in mucosa structural constituent of ribosome extracellular space ribosome translation antibacterial humoral response cytosolic large ribosomal subunit polysomal ribosome defense response to Gram-positive bacterium uc009syc.1 uc009syc.2 uc009syc.3 uc009syc.4 
ENSMUST00000115237.8 Ntm ENSMUST00000115237.8 neurotrimin, transcript variant 7 (from RefSeq NM_001357603.1) ENSMUST00000115237.1 ENSMUST00000115237.2 ENSMUST00000115237.3 ENSMUST00000115237.4 ENSMUST00000115237.5 ENSMUST00000115237.6 ENSMUST00000115237.7 Hnt NM_001357603 NTRI_MOUSE Nt Q99PJ0 uc009oqt.1 uc009oqt.2 uc009oqt.3 Neural cell adhesion molecule. Cell membrane; Lipid-anchor, GPI-anchor. Belongs to the immunoglobulin superfamily. IgLON family. extracellular space plasma membrane cell adhesion cell surface negative regulation of neuron projection development membrane axon anchored component of membrane perinuclear region of cytoplasm excitatory synapse uc009oqt.1 uc009oqt.2 uc009oqt.3 
ENSMUST00000115238.10 Ahcyl2 ENSMUST00000115238.10 S-adenosylhomocysteine hydrolase-like 2, transcript variant 3 (from RefSeq NM_001171001.1) ENSMUST00000115238.1 ENSMUST00000115238.2 ENSMUST00000115238.3 ENSMUST00000115238.4 ENSMUST00000115238.5 ENSMUST00000115238.6 ENSMUST00000115238.7 ENSMUST00000115238.8 ENSMUST00000115238.9 NM_001171001 Q68FL4 Q8BIH1 SAHH3_MOUSE uc009bek.1 uc009bek.2 uc009bek.3 uc009bek.4 May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate. Reaction=H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine; Xref=Rhea:RHEA:21708, ChEBI:CHEBI:15377, ChEBI:CHEBI:16335, ChEBI:CHEBI:57856, ChEBI:CHEBI:58199; EC=3.13.2.1; Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence=; Note=Binds 1 NAD(+) per subunit. ; Amino-acid biosynthesis; L-homocysteine biosynthesis; L- homocysteine from S-adenosyl-L-homocysteine: step 1/1. Homotetramer. Forms heteromultimers with AHCYL1 (via the C- terminal region). Interacts with ITPR1; with lower affinity than AHCYL1 and maybe via ITPR1. Interacts with SLC4A4. Interacts with ZCCHC4 (By similarity). Cytoplasm crosome Note=Associates with membranes when phosphorylated, probably through interaction with ITPR1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q68FL4-1; Sequence=Displayed; Name=2; IsoId=Q68FL4-2; Sequence=VSP_017821; Highly expressed in cerebrum, cerebellum and kidney. Also expressed in thymus, spleen, testis, ovary and, at lower, levels in lung and liver (at protein level). In cerebellum, expressed in interneurons. Phosphorylated during neuronal differentiation at the LISN domain. Belongs to the adenosylhomocysteinase family. cytoplasm endoplasmic reticulum cytosol one-carbon metabolic process hydrolase activity S-adenosylmethionine cycle neuron projection intracellular membrane-bounded organelle adenosylhomocysteinase activity uc009bek.1 uc009bek.2 uc009bek.3 uc009bek.4 
ENSMUST00000115244.9 Col19a1 ENSMUST00000115244.9 collagen, type XIX, alpha 1 (from RefSeq NM_007733.2) COJA1_MOUSE Col19a1 ENSMUST00000115244.1 ENSMUST00000115244.2 ENSMUST00000115244.3 ENSMUST00000115244.4 ENSMUST00000115244.5 ENSMUST00000115244.6 ENSMUST00000115244.7 ENSMUST00000115244.8 NM_007733 O35053 Q0VF58 uc007amq.1 uc007amq.2 uc007amq.3 May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. Oligomer; disulfide-linked. Secreted, extracellular space, extracellular matrix Expressed in the myotome of somites from 9.5 dpc. In muscular tissues, expression is transient and is confined to a few sites of the developing embryo, such as limbs, tongue, and smooth muscle layers of stomach and esophagus. Also detected in skin at 16.5 dpc and in cerebral cortex and hippocampus of the newborn brain. In adult, expression is only observed in cerebrum, cerebellum, eyes, and testis. In CNS, expression gradually increases following birth. Also expressed in embryonic fibroblasts and to a lesser extent in adult fibroblasts. The numerous interruptions in the triple helix may make this molecule either elastic or flexible. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Mice show severe signs of malnourishment and the majority die within the first three weeks of postnatal life. Newborn homozygotes do not show gross anatomical abnormalities, except for smaller size of the internal organs. However, necroscopy of the mice that survive past the weaning stage reveals a dilated esophagus (megaesophagus) with retention of ingesta immediately above the diaphragm level. Mutant mice also exhibit an additional defect, namely impaired smooth-to-skeletal muscle cell transdifferentiation in the abdominal segment of the esophagus. Heterozygotes by comparison are morphologically normal, viable and fertile. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. morphogenesis of a branching structure extracellular matrix structural constituent extracellular region collagen trimer extracellular space cell-cell junction cell adhesion cell-matrix adhesion multicellular organism development muscle organ development skeletal muscle tissue development heparin binding cell differentiation extracellular matrix organization extracellular matrix cell-cell adhesion uc007amq.1 uc007amq.2 uc007amq.3 
ENSMUST00000115245.8 Ccdc146 ENSMUST00000115245.8 coiled-coil domain containing 146 (from RefSeq NM_029195.1) Ccdc146 E9Q9F7 E9Q9F7_MOUSE ENSMUST00000115245.1 ENSMUST00000115245.2 ENSMUST00000115245.3 ENSMUST00000115245.4 ENSMUST00000115245.5 ENSMUST00000115245.6 ENSMUST00000115245.7 NM_029195 uc008wok.1 uc008wok.2 uc008wok.3 molecular_function centriole biological_process uc008wok.1 uc008wok.2 uc008wok.3 
ENSMUST00000115253.3 Ct47 ENSMUST00000115253.3 Ct47 (from geneSymbol) A2A3U9 A2A3U9_MOUSE Ct47 ENSMUST00000115253.1 ENSMUST00000115253.2 Gm6268 uc029xjh.1 uc029xjh.2 uc029xjh.3 molecular_function cellular_component biological_process uc029xjh.1 uc029xjh.2 uc029xjh.3 
ENSMUST00000115258.9 Zcchc12 ENSMUST00000115258.9 zinc finger, CCHC domain containing 12, transcript variant 1 (from RefSeq NM_028325.4) ENSMUST00000115258.1 ENSMUST00000115258.2 ENSMUST00000115258.3 ENSMUST00000115258.4 ENSMUST00000115258.5 ENSMUST00000115258.6 ENSMUST00000115258.7 ENSMUST00000115258.8 NM_028325 Q9CZA5 Sizn1 ZCH12_MOUSE uc009sxk.1 uc009sxk.2 uc009sxk.3 uc009sxk.4 Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic- neuron-specific gene expression. Interacts with SMAD1 and CREB-binding protein (CBP). Forms a protein-DNA complex through its association with SMAD1. In embryonic brains expression is restricted to the ventral region of the forebrain, including the septum, amygdala, caudal putamen, and in the basal-forebrain cholinergic neurons. In adults, expressed in the brain, and at low levels in the testis. Belongs to the ZCCHC12 family. nucleic acid binding protein binding nucleus zinc ion binding nuclear speck ligand-dependent nuclear receptor transcription coactivator activity BMP signaling pathway SUMO binding metal ion binding positive regulation of ligand-dependent nuclear receptor transcription coactivator activity uc009sxk.1 uc009sxk.2 uc009sxk.3 uc009sxk.4 
ENSMUST00000115259.3 Tmem60 ENSMUST00000115259.3 transmembrane protein 60 (from RefSeq NM_177601.3) ENSMUST00000115259.1 ENSMUST00000115259.2 NM_177601 Q8BRZ0 Q8K174 TMM60_MOUSE uc008woc.1 uc008woc.2 uc008woc.3 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc008woc.1 uc008woc.2 uc008woc.3 
ENSMUST00000115261.3 Gm1110 ENSMUST00000115261.3 predicted gene 1110 (from RefSeq NM_001281475.1) ENSMUST00000115261.1 ENSMUST00000115261.2 F6Y113 F6Y113_MOUSE Gm1110 NM_001281475 uc033jjr.1 uc033jjr.2 uc033jjr.3 Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.; EC=3.2.1.23; Evidence=; Belongs to the glycosyl hydrolase 35 family. hydrolase activity, hydrolyzing O-glycosyl compounds beta-galactosidase activity vacuole carbohydrate metabolic process biological_process metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds uc033jjr.1 uc033jjr.2 uc033jjr.3 
ENSMUST00000115262.9 Msrb1 ENSMUST00000115262.9 methionine sulfoxide reductase B1, transcript variant 1 (from RefSeq NM_013759.3) ENSMUST00000115262.1 ENSMUST00000115262.2 ENSMUST00000115262.3 ENSMUST00000115262.4 ENSMUST00000115262.5 ENSMUST00000115262.6 ENSMUST00000115262.7 ENSMUST00000115262.8 MSRB1_MOUSE NM_013759 Q545U8 Q9JLC3 Sepr Sepx1 uc008ayi.1 uc008ayi.2 The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2016]. Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine (PubMed:11929995, PubMed:14699060, PubMed:23911929, PubMed:20605785). While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue (PubMed:14699060, PubMed:20605785). Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization (PubMed:23911929). Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages (PubMed:23911929). Reaction=[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]; Xref=Rhea:RHEA:24164, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12314, ChEBI:CHEBI:15377, ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:45764, ChEBI:CHEBI:50058; EC=1.8.4.12; Evidence=; Reaction=[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]- dithiol + L-methionine (R)-S-oxide; Xref=Rhea:RHEA:21260, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57844, ChEBI:CHEBI:58773; EC=1.8.4.14; Evidence= Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. Cytoplasm Nucleus Cytoplasm, cytoskeleton Truncated MSRB1/SEPX1 proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(FEM1C) E3 ubiquitin-protein ligase complex. Belongs to the MsrB Met sulfoxide reductase family. immune system process actin binding nucleus cytoplasm cytoskeleton zinc ion binding oxidoreductase activity actin filament polymerization protein repair peptide-methionine (R)-S-oxide reductase activity L-methionine-(R)-S-oxide reductase activity innate immune response metal ion binding oxidation-reduction process methionine-R-sulfoxide reductase activity actin cytoskeleton uc008ayi.1 uc008ayi.2 
ENSMUST00000115268.4 Csf1r ENSMUST00000115268.4 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; (from UniProt Q0P635) AK155576 Csf1r ENSMUST00000115268.1 ENSMUST00000115268.2 ENSMUST00000115268.3 Q0P635 Q0P635_MOUSE uc289pgr.1 uc289pgr.2 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Cell membrane ; Single-pass type I membrane protein Membrane ingle-pass type I membrane protein Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. nucleotide binding positive regulation of protein phosphorylation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity macrophage colony-stimulating factor receptor activity ATP binding nucleoplasm plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway cell proliferation positive regulation of cell proliferation regulation of cell shape membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cytokine binding hemopoiesis cellular response to macrophage colony-stimulating factor stimulus macrophage colony-stimulating factor signaling pathway intracellular membrane-bounded organelle cell-cell junction maintenance protein autophosphorylation positive regulation of protein tyrosine kinase activity positive regulation of chemokine secretion positive regulation of cell motility uc289pgr.1 uc289pgr.2 
ENSMUST00000115275.8 Ccdc136 ENSMUST00000115275.8 coiled-coil domain containing 136, transcript variant 14 (from RefSeq NM_001405651.1) Ccdc136 D3Z165 D3Z165_MOUSE ENSMUST00000115275.1 ENSMUST00000115275.2 ENSMUST00000115275.3 ENSMUST00000115275.4 ENSMUST00000115275.5 ENSMUST00000115275.6 ENSMUST00000115275.7 NM_001405651 uc057lpe.1 uc057lpe.2 uc057lpe.3 membrane integral component of membrane uc057lpe.1 uc057lpe.2 uc057lpe.3 
ENSMUST00000115286.4 Garin1a ENSMUST00000115286.4 golgi associated RAB2 interactor 1A, transcript variant 3 (from RefSeq NM_001411706.1) B2RXB0 ENSMUST00000115286.1 ENSMUST00000115286.2 ENSMUST00000115286.3 Fam137b Fam71f2 GAR1A_MOUSE GARI Garin1a NM_001411706 uc009bde.1 uc009bde.2 uc009bde.3 uc009bde.4 RAB2B effector protein required for accurate acrosome formation and normal male fertility. Interacts (via N-terminus) with RAB2B (in GTP-bound form). Golgi apparatus Expressed in testis (at protein level). Expressed from day 21, around when spermiogenesis occurs (PubMed:34714330). Expression dramatically increases at the mid- round spermatid stage (steps 4-6) (PubMed:34714330). Mutant male fertility is significantly impaired compared with that of the controls (PubMed:34714330). Spermatozoa from mutant mice showed abnormal head shapes with an abnormal acrosome morphology (PubMed:34714330). Belongs to the GARIN family. molecular_function biological_process uc009bde.1 uc009bde.2 uc009bde.3 uc009bde.4 
ENSMUST00000115310.9 Trp63 ENSMUST00000115310.9 transformation related protein 63, transcript variant 9 (from RefSeq NM_001427037.1) ENSMUST00000115310.1 ENSMUST00000115310.2 ENSMUST00000115310.3 ENSMUST00000115310.4 ENSMUST00000115310.5 ENSMUST00000115310.6 ENSMUST00000115310.7 ENSMUST00000115310.8 NM_001427037 O88897 O88898 O88899 O89097 P63 P63_MOUSE P73l Q8C826 Q9QWY9 Q9QWZ0 Tp63 Tp73l uc007yup.1 uc007yup.2 uc007yup.3 uc007yup.4 Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Interacts with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Interacts with PDS5A. Interacts (via activation domain) with NOC2L (By similarity). Interacts with WWP1. O88898; Q9ESJ1: Cables1; NbExp=2; IntAct=EBI-2338025, EBI-604411; O88898; O88898: Tp63; NbExp=2; IntAct=EBI-2338025, EBI-2338025; O88898; P04637: TP53; Xeno; NbExp=2; IntAct=EBI-2338025, EBI-366083; O88898-1; O88898-1: Tp63; NbExp=19; IntAct=EBI-3863990, EBI-3863990; O88898-2; O88898-2: Tp63; NbExp=2; IntAct=EBI-2338228, EBI-2338228; O88898-2; Q92831: KAT2B; Xeno; NbExp=3; IntAct=EBI-2338228, EBI-477430; O88898-5; O88898-5: Tp63; NbExp=5; IntAct=EBI-2338240, EBI-2338240; Nucleus Event=Alternative promoter usage, Alternative splicing; Named isoforms=6; Name=1; Synonyms=TA*-alpha, TA*p63alpha; IsoId=O88898-1; Sequence=Displayed; Name=2; Synonyms=DeltaN-alpha; IsoId=O88898-2; Sequence=VSP_012471; Name=3; Synonyms=TA*-beta, TA*p63beta; IsoId=O88898-3; Sequence=VSP_012474; Name=4; Synonyms=DeltaN-beta; IsoId=O88898-4; Sequence=VSP_012471, VSP_012474; Name=5; Synonyms=TA*-gamma, TA*p63gamma; IsoId=O88898-5; Sequence=VSP_012472, VSP_012473; Name=6; Synonyms=DeltaN-gamma; IsoId=O88898-6; Sequence=VSP_012471, VSP_012472, VSP_012473; Widely expressed, notably in thymus, prostate, placenta and skeletal muscle, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast and prostate express high levels of DeltaN-type isoforms. Expressed in the basal layer and a small number of cells in the spinous layer of the tongue at P20. [Isoform 1]: Expressed in the epidermis from 7.5 dpc, prior to onset of epithelial stratification. [Isoform 2]: Expressed in the epidermis from 9.5 dpc, after the onset of epithelial stratification but prior to terminal differentiation. [Isoform 3]: Expressed in the epidermis from 7.5 dpc, prior to onset of epithelial stratification. [Isoform 4]: Expressed in the epidermis from 9.5 dpc, after the onset of epithelial stratification but prior to terminal differentiation. [Isoform 5]: Expressed in the epidermis from 7.5 dpc, prior to onset of epithelial stratification. [Isoform 6]: Expressed in the epidermis from 9.5 dpc, after the onset of epithelial stratification but prior to terminal differentiation. Induced by DNA damaging agents. The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms. May be sumoylated. Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. [Isoform 1]: Produced by alternative promoter usage. [Isoform 2]: Produced by alternative promoter usage. [Isoform 3]: Produced by alternative splicing of isoform 1. [Isoform 4]: Produced by alternative splicing of isoform 2. [Isoform 5]: Produced by alternative splicing of isoform 1. [Isoform 6]: Produced by alternative splicing of isoform 2. Belongs to the p53 family. Sequence=BAC33397.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; negative regulation of transcription from RNA polymerase II promoter nuclear chromatin transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding replicative cell aging skeletal system development establishment of planar polarity morphogenesis of a polarized epithelium hair follicle development p53 binding epithelial cell development DNA binding chromatin binding damaged DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm rough endoplasmic reticulum Golgi apparatus cytosol chromatin remodeling regulation of transcription, DNA-templated apoptotic process cellular response to DNA damage stimulus Notch signaling pathway multicellular organism development spermatogenesis pattern specification process ectoderm and mesoderm interaction aging cell aging cell proliferation epidermis development animal organ morphogenesis epidermal cell differentiation proximal/distal pattern formation multicellular organism aging epidermal cell division regulation of epidermal cell division positive regulation of keratinocyte proliferation protein domain specific binding cell differentiation keratinocyte differentiation embryonic limb morphogenesis dendrite prostate gland development epithelial cell differentiation polarized epithelial cell differentiation hair follicle morphogenesis developmental process macromolecular complex negative regulation of intracellular estrogen receptor signaling pathway embryonic forelimb morphogenesis embryonic hindlimb morphogenesis post-anal tail morphogenesis odontogenesis of dentin-containing tooth intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator identical protein binding neuron projection regulation of cysteine-type endopeptidase activity involved in apoptotic process sequence-specific DNA binding skin morphogenesis keratinocyte proliferation transcription regulatory region DNA binding negative regulation of keratinocyte differentiation positive regulation of osteoblast differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding sympathetic nervous system development anatomical structure formation involved in morphogenesis female genitalia morphogenesis WW domain binding protein tetramerization protein homotetramerization neuron apoptotic process cloacal septation prostatic bud formation squamous basal epithelial stem cell differentiation involved in prostate gland acinus development establishment of skin barrier MDM2/MDM4 family protein binding skin epidermis development positive regulation of cell cycle G1/S phase transition positive regulation of somatic stem cell population maintenance cranial skeletal system development positive regulation of fibroblast apoptotic process negative regulation of mesoderm development negative regulation of cellular senescence positive regulation of apoptotic signaling pathway uc007yup.1 uc007yup.2 uc007yup.3 uc007yup.4 
ENSMUST00000115319.9 Klhl13 ENSMUST00000115319.9 kelch-like 13, transcript variant 2 (from RefSeq NM_001290476.2) A2AL86 A2AL87 A2AL88 A2AL89 Bklhd2 ENSMUST00000115319.1 ENSMUST00000115319.2 ENSMUST00000115319.3 ENSMUST00000115319.4 ENSMUST00000115319.5 ENSMUST00000115319.6 ENSMUST00000115319.7 ENSMUST00000115319.8 KLH13_MOUSE Kiaa1309 NM_001290476 Q80TF4 Q9DBY7 uc009sut.1 uc009sut.2 uc009sut.3 uc009sut.4 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity). Protein modification; protein ubiquitination. Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB (By similarity). Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q80TF4-1; Sequence=Displayed; Name=2; IsoId=Q80TF4-2; Sequence=VSP_037535; Name=3; IsoId=Q80TF4-3; Sequence=VSP_037536; Name=4; IsoId=Q80TF4-4; Sequence=VSP_037537; Name=5; IsoId=Q80TF4-5; Sequence=VSP_037534; Sequence=BAC65773.1; Type=Erroneous initiation; Evidence=; ubiquitin-protein transferase activity cell cycle protein ubiquitination midbody Cul3-RING ubiquitin ligase complex regulation of cytokinesis cell division uc009sut.1 uc009sut.2 uc009sut.3 uc009sut.4 
ENSMUST00000115330.8 Pot1a ENSMUST00000115330.8 protection of telomeres 1A (from RefSeq NM_133931.5) ENSMUST00000115330.1 ENSMUST00000115330.2 ENSMUST00000115330.3 ENSMUST00000115330.4 ENSMUST00000115330.5 ENSMUST00000115330.6 ENSMUST00000115330.7 NM_133931 POTE1_MOUSE Pot1 Q8BUH9 Q91WC1 uc009bce.1 uc009bce.2 uc009bce.3 Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis- inhibition of telomerase. Also acts as a single-stranded telomeric DNA- binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'- TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity (By similarity). Homodimer or homooligomer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1. Binds single-stranded telomeric DNA as a monomer. Associated component of the telomerase holoenzyme complex. Found in a complex with TERF1, TINF2 and TNKS1. Interacts with TNKS1. Forms heterodimers with ACD. Identified in a complex with ACD and single-stranded telomeric DNA. Q91WC1; Q5EE38-1: Acd; NbExp=2; IntAct=EBI-7051001, EBI-15647355; Q91WC1; O89023: Tpp1; NbExp=2; IntAct=EBI-7051001, EBI-7051084; Q91WC1; Q96AP0: ACD; Xeno; NbExp=3; IntAct=EBI-7051001, EBI-717666; Nucleus Chromosome, telomere Note=Colocalizes with telomeric DNA. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91WC1-1; Sequence=Displayed; Name=2; IsoId=Q91WC1-2; Sequence=VSP_010848, VSP_010849; Belongs to the telombin family. telomere maintenance chromosome, telomeric region nuclear telomere cap complex nuclear chromosome, telomeric region DNA binding protein binding nucleus nucleoplasm chromosome telomere maintenance via telomerase telomerase inhibitor activity telomere capping DEAD/H-box RNA helicase binding telomere assembly regulation of telomere maintenance via telomerase negative regulation of telomere maintenance via telomerase positive regulation of telomere maintenance via telomerase DNA duplex unwinding telomeric DNA binding single-stranded telomeric DNA binding positive regulation of helicase activity chromosome organization positive regulation of telomerase activity negative regulation of telomerase activity positive regulation of DNA strand elongation telomeric D-loop disassembly telomeric D-loop binding telosome establishment of protein localization to telomere G-rich strand telomeric DNA binding 8-hydroxy-2'-deoxyguanosine DNA binding regulation of DNA helicase activity positive regulation of DNA helicase activity G-rich single-stranded DNA binding telomeric loop formation uc009bce.1 uc009bce.2 uc009bce.3 
ENSMUST00000115333.9 Zfp182 ENSMUST00000115333.9 zinc finger protein 182, transcript variant 1 (from RefSeq NM_001013387.2) A2AE18 A2AE18_MOUSE ENSMUST00000115333.1 ENSMUST00000115333.2 ENSMUST00000115333.3 ENSMUST00000115333.4 ENSMUST00000115333.5 ENSMUST00000115333.6 ENSMUST00000115333.7 ENSMUST00000115333.8 NM_001013387 Zfp182 uc009sui.1 uc009sui.2 uc009sui.3 uc009sui.4 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009sui.1 uc009sui.2 uc009sui.3 uc009sui.4 
ENSMUST00000115340.8 Crisp4 ENSMUST00000115340.8 Belongs to the CRISP family. (from UniProt Q9D259) AY705449 Crisp4 ENSMUST00000115340.1 ENSMUST00000115340.2 ENSMUST00000115340.3 ENSMUST00000115340.4 ENSMUST00000115340.5 ENSMUST00000115340.6 ENSMUST00000115340.7 Q9D259 Q9D259_MOUSE uc007aki.1 uc007aki.2 uc007aki.3 Belongs to the CRISP family. Lacks conserved residue(s) required for the propagation of feature annotation. calcium channel regulator activity extracellular region extracellular space binding of sperm to zona pellucida regulation of acrosome reaction uc007aki.1 uc007aki.2 uc007aki.3 
ENSMUST00000115342.10 Timp1 ENSMUST00000115342.10 Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14 (By similarity). Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. (from UniProt P12032) ENSMUST00000115342.1 ENSMUST00000115342.2 ENSMUST00000115342.3 ENSMUST00000115342.4 ENSMUST00000115342.5 ENSMUST00000115342.6 ENSMUST00000115342.7 ENSMUST00000115342.8 ENSMUST00000115342.9 P12032 P20064 Q61720 TIMP1_MOUSE Timp Timp-1 X04684 uc009stz.1 uc009stz.2 uc009stz.3 Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14 (By similarity). Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14 (By similarity). Interacts with CD63; identified in a complex with CD63 and ITGB1. Secreted Found in fetal and adult tissues. Highest levels are found in bone. Also found in lung, ovary and uterus. Present in unfertilized eggs and at the zygote and cleavage stages. Levels increase at the blastocyst stage and with endoderm differentiation. Regulated by tumor promoters and mitogens through protein kinase C. Also induced by viruses. The activity of TIMP1 is dependent on the presence of disulfide bonds. N-glycosylated. Belongs to the protease inhibitor I35 (TIMP) family. cell activation protease binding connective tissue replacement involved in inflammatory response wound healing enzyme inhibitor activity cytokine activity extracellular region basement membrane extracellular space signal transduction aging growth factor activity metalloendopeptidase inhibitor activity zinc ion binding positive regulation of cell proliferation response to hormone response to organic substance negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity extracellular matrix response to cytokine wound healing negative regulation of apoptotic process negative regulation of catalytic activity response to peptide hormone metal ion binding negative regulation of membrane protein ectodomain proteolysis cartilage development negative regulation of trophoblast cell migration negative regulation of metallopeptidase activity regulation of integrin-mediated signaling pathway uc009stz.1 uc009stz.2 uc009stz.3 
ENSMUST00000115349.9 Kng2 ENSMUST00000115349.9 kininogen 2, transcript variant 2 (from RefSeq NM_001102409.1) ENSMUST00000115349.1 ENSMUST00000115349.2 ENSMUST00000115349.3 ENSMUST00000115349.4 ENSMUST00000115349.5 ENSMUST00000115349.6 ENSMUST00000115349.7 ENSMUST00000115349.8 Kng2 NM_001102409 Q6S9I0 Q6S9I0_MOUSE uc007ysx.1 uc007ysx.2 uc007ysx.3 Secreted, extracellular space cysteine-type endopeptidase inhibitor activity receptor binding extracellular region extracellular space cell positive regulation of cytosolic calcium ion concentration negative regulation of endopeptidase activity negative regulation of blood coagulation uc007ysx.1 uc007ysx.2 uc007ysx.3 
ENSMUST00000115351.10 Rab3d ENSMUST00000115351.10 RAB3D, member RAS oncogene family, transcript variant 2 (from RefSeq NM_001324531.1) ENSMUST00000115351.1 ENSMUST00000115351.2 ENSMUST00000115351.3 ENSMUST00000115351.4 ENSMUST00000115351.5 ENSMUST00000115351.6 ENSMUST00000115351.7 ENSMUST00000115351.8 ENSMUST00000115351.9 NM_001324531 Q543Q4 Q543Q4_MOUSE Rab3D Rab3d uc009omv.1 uc009omv.2 uc009omv.3 uc009omv.4 Protein transport. Probably involved in vesicular traffic. Cell membrane ipid-anchor ; Cytoplasmic side mbrane ; Lipid-anchor ; Cytoplasmic side Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding cytoplasmic microtubule transport vesicle myosin V binding bone resorption secretory vesicle positive regulation of regulated secretory pathway uc009omv.1 uc009omv.2 uc009omv.3 uc009omv.4 
ENSMUST00000115354.2 Rnf133 ENSMUST00000115354.2 Has E3 ubiquitin-protein ligase activity. (from UniProt Q14B02) BC116423 ENSMUST00000115354.1 Greul2 Q14B02 Q8C1F1 Q8CGR0 RN133_MOUSE uc029vtq.1 uc029vtq.2 Has E3 ubiquitin-protein ligase activity. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Endoplasmic reticulum membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14B02-1; Sequence=Displayed; Name=2; IsoId=Q14B02-2; Sequence=VSP_037829; Testis-specific. Expression begins in the testis at day 21 and increases dramatically from day 28 and thereafter. Auto-ubiquitinated. late endosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination transferase activity metal ion binding protein autoubiquitination ubiquitin protein ligase activity uc029vtq.1 uc029vtq.2 
ENSMUST00000115358.9 Cadps2 ENSMUST00000115358.9 Ca2+-dependent activator protein for secretion 2, transcript variant 3 (from RefSeq NM_001252106.2) CAPS2_MOUSE Caps2 ENSMUST00000115358.1 ENSMUST00000115358.2 ENSMUST00000115358.3 ENSMUST00000115358.4 ENSMUST00000115358.5 ENSMUST00000115358.6 ENSMUST00000115358.7 ENSMUST00000115358.8 NM_001252106 O08903 Q66JM7 Q6PCL7 Q76I88 Q7TMM6 Q80ZV8 Q8BL25 Q8BY04 Q8BYR5 Q8K3K6 uc033ioi.1 uc033ioi.2 uc033ioi.3 uc033ioi.4 Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. Homodimer. Interacts with the dopamine receptor DRD2 (By similarity). Q8BYR5; P61750: Arf4; NbExp=2; IntAct=EBI-7569313, EBI-7569554; Q8BYR5; P84084: Arf5; NbExp=5; IntAct=EBI-7569313, EBI-7569461; Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Synapse te=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles. Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q8BYR5-1; Sequence=Displayed; Name=2; IsoId=Q8BYR5-2; Sequence=VSP_016824; Name=3; Synonyms=CAPS2b; IsoId=Q8BYR5-3; Sequence=VSP_016819, VSP_016824; Name=4; IsoId=Q8BYR5-4; Sequence=VSP_016824, VSP_016826; Name=5; IsoId=Q8BYR5-5; Sequence=VSP_016825, VSP_016826, VSP_016827; Name=6; IsoId=Q8BYR5-6; Sequence=VSP_016822, VSP_016823; Name=7; IsoId=Q8BYR5-7; Sequence=VSP_016820, VSP_016821; Highly expressed in cerebellum. Also expressed in non-neuronal tissues such as lung, spleen, testis, uterus and ovary. Highly expressed in brain. In brain, it is highly expressed in cerebellum, cortex, olfactory bulb, CA1/CA2 regions of the hippocampus, and dentate gyrus, and weakly or not expressed in the CA3 regions of the hippocampus, striatum, thalamus, superior and inferior colliculi, and brain stem. Not present in adult adrenal glands. Isoform 4, but not isoform 3, is highly expressed in postnatal and adult stages of cerebellum. Expressed at stable level during brain development, with a higher level in embryonic brain. The PH domain is essential for regulated exocytosis and binds phospholipids. Sequence=AAB58720.2; Type=Frameshift; Evidence=; Sequence=AAH59274.1; Type=Erroneous initiation; Evidence=; [Isoform 6]: Sequence=AAH55462.1; Type=Frameshift; Evidence=; protein binding nucleoplasm exocytosis lipid binding cellular response to starvation protein transport membrane synaptic vesicle exocytosis synaptic vesicle priming cell junction cytoplasmic vesicle membrane cytoplasmic vesicle presynaptic membrane intracellular membrane-bounded organelle synapse postsynaptic membrane positive regulation of exocytosis metal ion binding presynapse glutamatergic synapse dense core granule exocytosis uc033ioi.1 uc033ioi.2 uc033ioi.3 uc033ioi.4 
ENSMUST00000115365.3 Tmem243 ENSMUST00000115365.3 transmembrane protein 243, mitochondrial (from RefSeq NM_001081029.1) 4930420K17Rik B2RVB9 B2RVB9_MOUSE ENSMUST00000115365.1 ENSMUST00000115365.2 NM_001081029 Tmem243 uc008wkv.1 uc008wkv.2 uc008wkv.3 molecular_function cellular_component biological_process membrane integral component of membrane uc008wkv.1 uc008wkv.2 uc008wkv.3 
ENSMUST00000115366.3 Slc12a2 ENSMUST00000115366.3 solute carrier family 12, member 2 (from RefSeq NM_009194.3) E9QM38 E9QM38_MOUSE ENSMUST00000115366.1 ENSMUST00000115366.2 NM_009194 Slc12a2 uc008ezm.1 uc008ezm.2 uc008ezm.3 Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) + K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the SLC12A transporter family. plasma membrane ion transport potassium ion transport sodium ion transport chloride transport hyperosmotic response gamma-aminobutyric acid signaling pathway aging sodium:potassium:chloride symporter activity ammonium transmembrane transporter activity T cell chemotaxis cation:chloride symporter activity ammonium transport membrane integral component of membrane protein kinase binding transmembrane transporter activity transepithelial chloride transport positive regulation of cell volume transmembrane transport transepithelial ammonium transport potassium ion transmembrane transport ammonium transmembrane transport chloride transmembrane transport cellular response to chemokine uc008ezm.1 uc008ezm.2 uc008ezm.3 
ENSMUST00000115374.8 Rbm10 ENSMUST00000115374.8 RNA binding motif protein 10, transcript variant 1 (from RefSeq NM_145627.3) ENSMUST00000115374.1 ENSMUST00000115374.2 ENSMUST00000115374.3 ENSMUST00000115374.4 ENSMUST00000115374.5 ENSMUST00000115374.6 ENSMUST00000115374.7 Kiaa0122 NM_145627 Q3TIY0 Q3U5B8 Q3UKI8 Q80U75 Q8BTP8 Q99KG3 RBM10_MOUSE Rbm10 uc009sth.1 uc009sth.2 uc009sth.3 uc009sth.4 Not known. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (By similarity). Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5 (By similarity). Nucleus Event=Alternative splicing, Alternative initiation; Named isoforms=4; Name=1; IsoId=Q99KG3-1; Sequence=Displayed; Name=2; IsoId=Q99KG3-2; Sequence=VSP_034905; Name=3; IsoId=Q99KG3-3; Sequence=VSP_034906; Name=Ribosome biogenesis inhibitor MINAS-60; IsoId=P0DW27-1; Sequence=External; RBM10 transcripts also code for an alternative open reading frame (alt-ORF) coding for the MINAS-60 (AC P0DW27) protein (Probable). MINAS-60 and RBM10 ORFs are overlapping and are formed by shifting the reading frame (Probable). Sequence=BAC65490.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus negative regulation of cell proliferation RNA splicing nuclear speck macromolecular complex regulation of smooth muscle cell apoptotic process positive regulation of smooth muscle cell apoptotic process miRNA binding identical protein binding regulation of apoptotic process metal ion binding negative regulation of mRNA splicing, via spliceosome 3'-UTR-mediated mRNA stabilization uc009sth.1 uc009sth.2 uc009sth.3 uc009sth.4 
ENSMUST00000115378.2 Rundc3b ENSMUST00000115378.2 RUN domain containing 3B, transcript variant 1 (from RefSeq NM_001347311.1) D3YUQ5 D3YUQ5_MOUSE ENSMUST00000115378.1 NM_001347311 Rundc3b uc057llm.1 uc057llm.2 uc057llm.3 Interacts with RAP2A. Belongs to the RUNDC3 family. uc057llm.1 uc057llm.2 uc057llm.3 
ENSMUST00000115383.9 Cped1 ENSMUST00000115383.9 cadherin-like and PC-esterase domain containing 1, transcript variant 6 (from RefSeq NM_001418026.1) A430107O13Rik B2RX70 B2RX70_MOUSE Cped1 ENSMUST00000115383.1 ENSMUST00000115383.2 ENSMUST00000115383.3 ENSMUST00000115383.4 ENSMUST00000115383.5 ENSMUST00000115383.6 ENSMUST00000115383.7 ENSMUST00000115383.8 NM_001418026 uc009bav.1 uc009bav.2 uc009bav.3 molecular_function endoplasmic reticulum biological_process uc009bav.1 uc009bav.2 uc009bav.3 
ENSMUST00000115384.9 Jade3 ENSMUST00000115384.9 jade family PHD finger 3, transcript variant 1 (from RefSeq NM_199317.3) A1L3T5 ENSMUST00000115384.1 ENSMUST00000115384.2 ENSMUST00000115384.3 ENSMUST00000115384.4 ENSMUST00000115384.5 ENSMUST00000115384.6 ENSMUST00000115384.7 ENSMUST00000115384.8 JADE3_MOUSE Kiaa0215 NM_199317 Phf16 Q6IE82 Q6ZQG2 uc009sta.1 uc009sta.2 uc009sta.3 uc009sta.4 Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Belongs to the JADE family. Sequence=BAC97901.1; Type=Frameshift; Evidence=; histone acetyltransferase complex molecular_function histone H3 acetylation histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K12 acetylation metal ion binding histone H4-K16 acetylation uc009sta.1 uc009sta.2 uc009sta.3 uc009sta.4 
ENSMUST00000115390.5 Ccnf ENSMUST00000115390.5 cyclin F, transcript variant 4 (from RefSeq NM_007634.5) CCNF_MOUSE ENSMUST00000115390.1 ENSMUST00000115390.2 ENSMUST00000115390.3 ENSMUST00000115390.4 NM_007634 P51944 Q3TF73 Q60797 Q60799 Q8BSX9 Q8C4D9 Q8CI26 uc008ave.1 uc008ave.2 uc008ave.3 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (By similarity). Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (By similarity). Mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (By similarity). In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (By similarity). Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (By similarity). May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (By similarity). Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF (By similarity). Interacts with SKP1 (By similarity). Interacts with CUL1 (By similarity). Interacts with CCNB1; interaction is required for nuclear localization of CCNB1 (By similarity). Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway (By similarity). Interacts (via the Cyclin N-terminal domain) with MYBL2/BMYB (By similarity). Interacts with FZR1/CDH1 (via N-terminus) (By similarity). Interacts with RRM2 (via Cy motif and when phosphorylated at 'Thr-33'); the interaction occurs exclusively in G2 and early M (By similarity). Interacts with CDC6 (via Cy motif); the interaction takes place during G2 and M phase (By similarity). Nucleus Cytoplasm, perinuclear region Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Localizes to the nucleus in G2 phase. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Short; IsoId=P51944-1; Sequence=Displayed; Name=2; Synonyms=Long; IsoId=P51944-2; Sequence=VSP_001257; Name=3; IsoId=P51944-3; Sequence=VSP_039778; Expression is activated by the FOXM1 transcription factor. The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus. The D box motifs 1-4 (amino acid sequence RxxL) are involved in substrate binding, such as FZR1/CDH1, and may be ubiquitinated. Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence. Phosphorylated just before cells enter into mitosis. Ubiquitinated by the anaphase-promoting complex (APC/C); leading to its degradation by the proteasome. Death by 10.5 dpc, with many developmental anomalies due in part to failures in yolk sac and chorioallantoic placentation. Heterozygous mice are normal and fertile. Belongs to the cyclin family. Cyclin AB subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein kinase holoenzyme complex re-entry into mitotic cell cycle placenta development nucleus cytoplasm centrosome centriole cytoskeleton protein phosphorylation cell cycle negative regulation of centrosome duplication cyclin-dependent protein serine/threonine kinase regulator activity protein ubiquitination SCF ubiquitin ligase complex protein kinase binding cell junction SCF-dependent proteasomal ubiquitin-dependent protein catabolic process mitotic cell cycle phase transition cell division regulation of cell cycle protein kinase activity uc008ave.1 uc008ave.2 uc008ave.3 
ENSMUST00000115391.8 Rp2 ENSMUST00000115391.8 retinitis pigmentosa 2 homolog, transcript variant 2 (from RefSeq NM_001290643.2) ENSMUST00000115391.1 ENSMUST00000115391.2 ENSMUST00000115391.3 ENSMUST00000115391.4 ENSMUST00000115391.5 ENSMUST00000115391.6 ENSMUST00000115391.7 NM_001290643 Q8BLN8 Q8BVQ8 Q8BZP9 Q9EPK2 Rp2h XRP2_MOUSE uc009ssw.1 uc009ssw.2 uc009ssw.3 uc009ssw.4 Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as a guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. Found in a complex with ARL3, RP2 and UNC119 (or UNC119B); RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119 (or UNC119B). Interacts with ARL3; interaction is direct and stimulated with the activated GTP-bound form of ARL3 (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Cell projection, cilium Note=Detected predominantly at the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9EPK2-1; Sequence=Displayed; Name=2; IsoId=Q9EPK2-2; Sequence=VSP_018482; Name=3; IsoId=Q9EPK2-3; Sequence=VSP_018483, VSP_018484; Name=4; IsoId=Q9EPK2-4; Sequence=VSP_018481; Retina (at protein level). Myristoylated on Gly-2; which may be required for membrane targeting. Palmitoylated on Cys-3; which may be required for plasma membrane targeting. Belongs to the TBCC family. nucleotide binding magnesium ion binding cell morphogenesis GTPase activator activity GTP binding nucleoplasm cytoplasm Golgi apparatus centriole plasma membrane cilium post-Golgi vesicle-mediated transport protein transport membrane nuclear body cytoplasmic vesicle ciliary basal body cell projection positive regulation of GTPase activity periciliary membrane compartment post-chaperonin tubulin folding pathway uc009ssw.1 uc009ssw.2 uc009ssw.3 uc009ssw.4 
ENSMUST00000115396.7 Ankrd7 ENSMUST00000115396.7 ankyrin repeat domain 7, transcript variant 1 (from RefSeq NM_001167757.1) A0A0R4J1L1 A0A0R4J1L1_MOUSE Ankrd7 ENSMUST00000115396.1 ENSMUST00000115396.2 ENSMUST00000115396.3 ENSMUST00000115396.4 ENSMUST00000115396.5 ENSMUST00000115396.6 NM_001167757 uc012eih.1 uc012eih.2 uc012eih.3 uc012eih.4 uc012eih.1 uc012eih.2 uc012eih.3 uc012eih.4 
ENSMUST00000115421.3 Steap4 ENSMUST00000115421.3 STEAP family member 4 (from RefSeq NM_054098.3) ENSMUST00000115421.1 ENSMUST00000115421.2 NM_054098 Q91W31 Q91ZE8 Q923B6 STEA4_MOUSE Tiarp uc008wjg.1 uc008wjg.2 uc008wjg.3 Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:16609065). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (PubMed:16609065). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (PubMed:17482547). Associated with obesity and insulin-resistance (By similarity). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (By similarity). Reaction=2 Fe(2+) + H(+) + NADP(+) = 2 Fe(3+) + NADPH; Xref=Rhea:RHEA:71767, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71769; Evidence=; Reaction=2 Cu(+) + H(+) + NADP(+) = 2 Cu(2+) + NADPH; Xref=Rhea:RHEA:71771, ChEBI:CHEBI:15378, ChEBI:CHEBI:29036, ChEBI:CHEBI:49552, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71773; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Can also utilize the flavins FMN and riboflavin. ; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Homotrimer. Interacts with PTK2/FAK1; the interaction may regulate PTK2 phosphorylation. Cell membrane ulti-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Expressed in white and brown adipose tissues cells, as well as in muscle and liver cells. Detected in joints and spleens of arthritic mice. By Tnfa (TNF-alpha), by Il6 in white and brown adipose tissue, and IL1B in white adipose tissue. Tnfa, Il6 and Il1b shows sinergistic stimulatory effects. Mice are viable and fertile, but exhibit overt inflammation with increased expression of Il6, Tnfa, Ccl2, haptoglobin and Socs3 in visceral adipose tissue as well as macrophage infiltration. They develop metabolic disease on regular diet with insulin resistance, glucose intolerance, mild hyperglycemia, dyslipidemia, and fatty liver disease. Adipocytes isolated from visceral fat exhibit severily defective glucose transport, with decreased expression of Slc2a4, Adipoq, Fas and Pparg. Glucose disposal is lower in response to insulin stimulation and hepatic glucose production is higher, confirming systemic and hepatic insulin- resistance. Belongs to the STEAP family. Sequence=AAK40270.1; Type=Frameshift; Evidence=; Golgi membrane endosome Golgi apparatus plasma membrane integral component of plasma membrane ion transport cupric reductase activity electron carrier activity copper ion import membrane integral component of membrane oxidoreductase activity heme binding electron transport chain early endosome membrane fat cell differentiation metal ion binding ferric-chelate reductase (NADPH) activity iron ion homeostasis oxidation-reduction process protein homotrimerization FAD binding ferric iron import across plasma membrane uc008wjg.1 uc008wjg.2 uc008wjg.3 
ENSMUST00000115426.9 Steap2 ENSMUST00000115426.9 six transmembrane epithelial antigen of prostate 2, transcript variant 2 (from RefSeq NM_028734.5) ENSMUST00000115426.1 ENSMUST00000115426.2 ENSMUST00000115426.3 ENSMUST00000115426.4 ENSMUST00000115426.5 ENSMUST00000115426.6 ENSMUST00000115426.7 ENSMUST00000115426.8 NM_028734 Q3TS12 Q8BWB6 STEA2_MOUSE uc008wiz.1 uc008wiz.2 uc008wiz.3 uc008wiz.4 uc008wiz.5 Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:16609065). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (PubMed:16609065). Reaction=2 Fe(2+) + H(+) + NADP(+) = 2 Fe(3+) + NADPH; Xref=Rhea:RHEA:71767, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71769; Evidence=; Reaction=2 Cu(+) + H(+) + NADP(+) = 2 Cu(2+) + NADPH; Xref=Rhea:RHEA:71771, ChEBI:CHEBI:15378, ChEBI:CHEBI:29036, ChEBI:CHEBI:49552, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71773; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Cell membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Belongs to the STEAP family. endosome early endosome cytosol plasma membrane ion transport Golgi to plasma membrane transport endocytosis cupric reductase activity response to hormone endosome membrane copper ion import membrane integral component of membrane oxidoreductase activity trans-Golgi network transport vesicle integral component of Golgi membrane regulated exocytosis metal ion binding ferric-chelate reductase (NADPH) activity iron ion homeostasis oxidation-reduction process ferric iron import across plasma membrane uc008wiz.1 uc008wiz.2 uc008wiz.3 uc008wiz.4 uc008wiz.5 
ENSMUST00000115428.2 Dcpp3 ENSMUST00000115428.2 demilune cell and parotid protein 3 (from RefSeq NM_001077633.1) Dcpp3 ENSMUST00000115428.1 L7N259 L7N259_MOUSE NM_001077633 uc008aub.1 uc008aub.2 molecular_function extracellular space biological_process uc008aub.1 uc008aub.2 
ENSMUST00000115433.11 Ap1m2 ENSMUST00000115433.11 adaptor protein complex AP-1, mu 2 subunit, transcript variant 3 (from RefSeq NM_001410422.1) A0A0R4J1L4 A0A0R4J1L4_MOUSE Ap1m2 ENSMUST00000115433.1 ENSMUST00000115433.10 ENSMUST00000115433.2 ENSMUST00000115433.3 ENSMUST00000115433.4 ENSMUST00000115433.5 ENSMUST00000115433.6 ENSMUST00000115433.7 ENSMUST00000115433.8 ENSMUST00000115433.9 NM_001410422 uc009oky.1 uc009oky.2 uc009oky.3 uc009oky.4 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus Belongs to the adaptor complexes medium subunit family. intracellular protein transport protein transport membrane vesicle-mediated transport clathrin adaptor complex intracellular membrane-bounded organelle uc009oky.1 uc009oky.2 uc009oky.3 uc009oky.4 
ENSMUST00000115436.9 Cask ENSMUST00000115436.9 calcium/calmodulin dependent serine protein kinase, transcript variant 4 (from RefSeq NM_009806.3) A2ADP8 A2ADP9 A2ADQ4 CSKP_MOUSE Cask ENSMUST00000115436.1 ENSMUST00000115436.2 ENSMUST00000115436.3 ENSMUST00000115436.4 ENSMUST00000115436.5 ENSMUST00000115436.6 ENSMUST00000115436.7 ENSMUST00000115436.8 Lin-2 NM_009806 O70588 O70589 Q3UW92 uc009srp.1 uc009srp.2 uc009srp.3 uc009srp.4 uc009srp.5 Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (By similarity). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D- aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Note=Unlike other protein kinases, does not require a divalent cation such as magnesium for catalytic activity. ; Differs from archetypal CaMK members in that the kinase domain exhibits a constitutively active conformation and the autoinhibitory region does not engage in direct contact with the ATP- binding cleft, although it still binds Ca(2+)/CAM. CASK and LIN7 form a tripartite complex with CASKIN1 (By similarity). Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (PubMed:10846156). Forms a heterotrimeric complex with DLG1 and LIN7B via their L27 domains (PubMed:22337881, PubMed:15863617). Identified in a complex with ACTN4, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1 (By similarity). Part of a complex containing CASK, TBR1 and TSPYL2 (PubMed:10749215, PubMed:15066269). Interacts with WHRN (By similarity). Interacts (via the PDZ, SH3 and guanylate kinase-like domains) with NRXN1 (via C-terminus) (PubMed:25385611). Interacts with CASKIN1, APBA1, LIN7(A/B/C), and L27 domain of DLG1 and isoform 2 of DLG4 (By similarity). Interacts with FCHSD2 (By similarity). Interacts with KIRREL3 (By similarity). Interacts with TBR1 (By similarity). Interacts with TSPYL2 (PubMed:15066269). Nucleus Cytoplasm Cell membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=CASK-B; IsoId=O70589-1; Sequence=Displayed; Name=2; Synonyms=CASK-A; IsoId=O70589-2; Sequence=VSP_003152, VSP_003153; Name=3; IsoId=O70589-3; Sequence=VSP_024614, VSP_024615; Name=4; IsoId=O70589-4; Sequence=VSP_024614, VSP_024616; Name=5; IsoId=O70589-5; Sequence=VSP_024614; The first L27 domain binds DLG1 and the second L27 domain probably binds LIN7. The protein kinase domain mediates the interaction with FCHSD2. In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Belongs to the MAGUK family. nucleotide binding negative regulation of cell-matrix adhesion protein kinase activity protein serine/threonine kinase activity protein binding calmodulin binding ATP binding basement membrane nucleus nuclear lamina nucleolus cytoplasm cytosol plasma membrane cell-cell junction regulation of transcription from RNA polymerase II promoter protein phosphorylation protein C-terminus binding negative regulation of keratinocyte proliferation postsynaptic density membrane kinase activity phosphorylation basolateral plasma membrane nuclear matrix transferase activity PDZ domain binding dendrite vesicle positive regulation of insulin secretion macromolecular complex neurexin family protein binding presynaptic membrane neuronal cell body macromolecular complex binding membrane raft synapse positive regulation of transcription from RNA polymerase II promoter ciliary membrane positive regulation of dendritic spine morphogenesis negative regulation of wound healing calcium ion import protein localization to plasma membrane positive regulation of calcium ion import negative regulation of cellular response to growth factor stimulus synaptic membrane apical dendrite podocyte foot regulation of synaptic vesicle exocytosis uc009srp.1 uc009srp.2 uc009srp.3 uc009srp.4 uc009srp.5 
ENSMUST00000115437.4 Thpo ENSMUST00000115437.4 thrombopoietin, transcript variant 1 (from RefSeq NM_009379.3) ENSMUST00000115437.1 ENSMUST00000115437.2 ENSMUST00000115437.3 NM_009379 Q543R9 Q543R9_MOUSE Thpo uc007yrb.1 uc007yrb.2 This gene encodes a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. The encoded protein is a ligand for the product of the myeloproliferative leukemia virus oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. Secreted Belongs to the EPO/TPO family. cytokine activity hormone activity extracellular region cell proliferation positive regulation of cell proliferation megakaryocyte development thrombopoietin-mediated signaling pathway positive regulation of MAPK cascade positive regulation of protein kinase B signaling STAT cascade positive regulation of hematopoietic stem cell proliferation uc007yrb.1 uc007yrb.2 
ENSMUST00000115441.9 Gtpbp10 ENSMUST00000115441.9 GTP-binding protein 10 (putative), transcript variant 1 (from RefSeq NM_153116.2) ENSMUST00000115441.1 ENSMUST00000115441.2 ENSMUST00000115441.3 ENSMUST00000115441.4 ENSMUST00000115441.5 ENSMUST00000115441.6 ENSMUST00000115441.7 ENSMUST00000115441.8 GTPBA_MOUSE NM_153116 Q8K013 uc008wis.1 uc008wis.2 uc008wis.3 May be involved in the ribosome maturation process. Nucleus, nucleolus. Note=Found in the dense fibrillar compartment region of the nucleolus. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. nucleotide binding GTP binding nucleus nucleolus mitochondrion biological_process ribosome biogenesis uc008wis.1 uc008wis.2 uc008wis.3 
ENSMUST00000115443.8 Met ENSMUST00000115443.8 met proto-oncogene, transcript variant 1 (from RefSeq NM_008591.3) ENSMUST00000115443.1 ENSMUST00000115443.2 ENSMUST00000115443.3 ENSMUST00000115443.4 ENSMUST00000115443.5 ENSMUST00000115443.6 ENSMUST00000115443.7 F8VQL0 F8VQL0_MOUSE Met NM_008591 uc009azr.1 uc009azr.2 uc009azr.3 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Membrane ; Single- pass type I membrane protein Belongs to the plexin family. Lacks conserved residue(s) required for the propagation of feature annotation. nucleotide binding endothelial cell morphogenesis protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway basal plasma membrane membrane integral component of membrane kinase activity phosphorylation transferase activity semaphorin receptor activity peptidyl-tyrosine phosphorylation protein phosphatase binding positive regulation of microtubule polymerization negative regulation of Rho protein signal transduction identical protein binding positive regulation of transcription from RNA polymerase II promoter branching morphogenesis of an epithelial tube positive chemotaxis negative regulation of stress fiber assembly establishment of skin barrier negative regulation of thrombin-activated receptor signaling pathway semaphorin-plexin signaling pathway negative regulation of hydrogen peroxide-mediated programmed cell death negative regulation of guanyl-nucleotide exchange factor activity positive regulation of endothelial cell chemotaxis uc009azr.1 uc009azr.2 uc009azr.3 
ENSMUST00000115447.2 Pttg1ip2 ENSMUST00000115447.2 PTTG1IP family member 2 (from RefSeq NM_001200025.1) D3YUK8 ENSMUST00000115447.1 NM_001200025 PTIP2_MOUSE Pttg1ip2 uc008wio.1 uc008wio.2 uc008wio.3 Membrane ; Single-pass type I membrane protein molecular_function nucleus cytoplasm protein import into nucleus membrane integral component of membrane uc008wio.1 uc008wio.2 uc008wio.3 
ENSMUST00000115461.8 Eif4g1 ENSMUST00000115461.8 eukaryotic translation initiation factor 4, gamma 1, transcript variant 7 (from RefSeq NM_001403464.1) E9PVC5 E9PVC5_MOUSE ENSMUST00000115461.1 ENSMUST00000115461.2 ENSMUST00000115461.3 ENSMUST00000115461.4 ENSMUST00000115461.5 ENSMUST00000115461.6 ENSMUST00000115461.7 Eif4g1 NM_001403464 uc289dmq.1 uc289dmq.2 Belongs to the eukaryotic initiation factor 4G family. RNA binding mRNA binding translation initiation factor activity translational initiation uc289dmq.1 uc289dmq.2 
ENSMUST00000115467.11 Tes ENSMUST00000115467.11 testin LIM domain protein (from RefSeq NM_207176.3) ENSMUST00000115467.1 ENSMUST00000115467.10 ENSMUST00000115467.2 ENSMUST00000115467.3 ENSMUST00000115467.4 ENSMUST00000115467.5 ENSMUST00000115467.6 ENSMUST00000115467.7 ENSMUST00000115467.8 ENSMUST00000115467.9 NM_207176 Q921B1 Q921W7 Q921W7_MOUSE Tes uc009azi.1 uc009azi.2 uc009azi.3 Cell junction, focal adhesion Belongs to the prickle / espinas / testin family. zinc ion binding regulation of cell proliferation metal ion binding uc009azi.1 uc009azi.2 uc009azi.3 
ENSMUST00000115468.9 Mybl1 ENSMUST00000115468.9 myeloblastosis oncogene-like 1, transcript variant 2 (from RefSeq NM_001290397.1) E9QLX9 E9QLX9_MOUSE ENSMUST00000115468.1 ENSMUST00000115468.2 ENSMUST00000115468.3 ENSMUST00000115468.4 ENSMUST00000115468.5 ENSMUST00000115468.6 ENSMUST00000115468.7 ENSMUST00000115468.8 Mybl1 NM_001290397 uc056ycd.1 uc056ycd.2 uc056ycd.3 Nucleus DNA binding nucleus regulation of transcription, DNA-templated uc056ycd.1 uc056ycd.2 uc056ycd.3 
ENSMUST00000115477.8 Foxp2 ENSMUST00000115477.8 forkhead box P2, transcript variant 1 (from RefSeq NM_053242.4) ENSMUST00000115477.1 ENSMUST00000115477.2 ENSMUST00000115477.3 ENSMUST00000115477.4 ENSMUST00000115477.5 ENSMUST00000115477.6 ENSMUST00000115477.7 FOXP2_MOUSE NM_053242 P58463 Q6PD37 Q8C4F0 Q8R441 uc009ayz.1 uc009ayz.2 Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding (By similarity). Interacts with CTBP1 (PubMed:14701752). Interacts with FOXP1 (By similarity). Interacts with TBR1 (By similarity). Interacts with ZMYM2 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P58463-1; Sequence=Displayed; Name=2; IsoId=P58463-2; Sequence=VSP_011540; Highest expression in lung. Lower expression in spleen, skeletal muscle, brain, kidney and small intestine. Expressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed at a high level in the distal airway epithelium and at a low level in the proximal airway epithelium at 12.5 dpc, and restricted to the distal airway epithelium by 14.5 dpc. In the spinal cord, at 12.5 dpc, expressed in a subset of interneurons dorsal to motor neurons. At 16.5 dpc, expression in the brain is observed in the inner intermediate zone of the neopallial cortex and in the developing cerebral hemispheres. In the gastrointestinal system, at 12.5 expressed in the outer mesodermal layer and in the intestinal epithelium. By 16.5 dpc, expression is restricted to the outer longitudinal muscle layer of the intestine and stomach. In the cardiovascular system, at 14.5 dpc, expressed in the outflow tract region of the developing heart. By 16.5 dpc, observed in the outflow tract and atrium, but not in the ventricles. The leucine-zipper is required for dimerization and transcriptional repression. [Isoform 2]: May be due to a competing acceptor splice site. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding positive regulation of mesenchymal cell proliferation DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated skeletal muscle tissue development post-embryonic development cerebellum development caudate nucleus development putamen development cerebral cortex development lung development forebrain development response to testosterone vocal learning identical protein binding protein homodimerization activity camera-type eye development sequence-specific DNA binding negative regulation of transcription, DNA-templated metal ion binding protein heterodimerization activity lung alveolus development smooth muscle tissue development positive regulation of epithelial cell proliferation androgen receptor binding righting reflex positive regulation of epithelial cell proliferation involved in lung morphogenesis innate vocalization behavior uc009ayz.1 uc009ayz.2 
ENSMUST00000115480.10 2610203C22Rik ENSMUST00000115480.10 RIKEN cDNA 2610203C22 gene (from RefSeq NR_015470.1) ENSMUST00000115480.1 ENSMUST00000115480.2 ENSMUST00000115480.3 ENSMUST00000115480.4 ENSMUST00000115480.5 ENSMUST00000115480.6 ENSMUST00000115480.7 ENSMUST00000115480.8 ENSMUST00000115480.9 NR_015470 uc007agn.1 uc007agn.2 uc007agn.3 uc007agn.4 uc007agn.5 uc007agn.6 uc007agn.1 uc007agn.2 uc007agn.3 uc007agn.4 uc007agn.5 uc007agn.6 
ENSMUST00000115487.3 Raver1 ENSMUST00000115487.3 ribonucleoprotein, PTB-binding 1 (from RefSeq NM_027911.4) ENSMUST00000115487.1 ENSMUST00000115487.2 Kiaa1978 NM_027911 Q5DTT6 Q811K0 Q8C3Z1 Q8CA14 Q9CW46 RAVR1_MOUSE uc009okd.1 uc009okd.2 uc009okd.3 uc009okd.4 Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Interacts with PTBP1, RAVER2, VCL and ACTN1. Part of a complex containing RAVER1, VCL and ACTN1. Nucleus Cytoplasm Note=Nuclear, in perinucleolar structures. Shuttles between nucleus and cytoplasm. Cytoplasm, at focal contacts and cell-cell contacts. Associated with myotubes during muscle differentiation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CW46-1; Sequence=Displayed; Name=2; IsoId=Q9CW46-2; Sequence=VSP_017037, VSP_017038; Ubiquitous. Sequence=BAB23670.1; Type=Erroneous initiation; Evidence=; nucleic acid binding RNA binding nucleus cytoplasm uc009okd.1 uc009okd.2 uc009okd.3 uc009okd.4 
ENSMUST00000115494.3 Zglp1 ENSMUST00000115494.3 zinc finger, GATA-like protein 1 (from RefSeq NM_001103168.1) ENSMUST00000115494.1 ENSMUST00000115494.2 Glp1 NM_001103168 Q1WG82 ZGLP1_MOUSE Zglp1 uc009veu.1 uc009veu.2 uc009veu.3 Transcriptional regulator that plays a key role in germ cell development (PubMed:16982049, PubMed:21123517, PubMed:32054698). Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry (PubMed:32054698). Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells (PubMed:32054698). Regulates expression of STRA8, a central downstream effector for the meiotic program (PubMed:32054698). Acts independently of retinoic acid (RA) (PubMed:32054698). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase (PubMed:32054698). Nucleus Specifically expressed in adult testis and ovary (PubMed:16982049). Expressed at high levels in the somatic cells of the developing gonads, including Leydig cells in the testes and granulosa cells in the ovaries (PubMed:16982049). During female embryogenesis, specifically and transiently expressed in germ cells expressing Ddx4: expression starts at 12.0 dpc and decreases after 14.5 dpc, a key period for the sex determination of germ cells (PubMed:21123517, PubMed:32054698). Not expressed in somatic cells or males during embryogenesis (PubMed:32054698). Up-regulated in response to bone morphogenetic proteins (BMPs) signaling. Mice are viable and normal; however, both males and females are completely infertile (PubMed:16982049, PubMed:32054698). In females, Zglp1 absence leads to a severe block in germ cell development as early as 17.5 dpc (PubMed:16982049). Ovaries at postnatal day (P) 8 and 6 weeks are highly atrophic with no ovarian follicles (PubMed:32054698). Ovaries as early as 17.5 dpc contain a drastically reduced number of cells expressing Ddx4 (PubMed:32054698). In males, Zglp1 absence leads to defective sperm development with a marked reduction in mature spermatids observed as early as postnatal week 1 (PubMed:16982049). Male germ cells develop normally until P7 (PubMed:32054698). Subsequently, they display severe impairment in the first wave of spermatogenesis: unlike in females, germ cells entered into meiotic prophase, but fail to progress beyond the zygotene stage, resulting in a large fraction of abnormal pachytene cells both at P15 and P20 (PubMed:32054698). negative regulation of transcription from RNA polymerase II promoter DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development spermatogenesis zinc ion binding sequence-specific DNA binding metal ion binding oocyte development uc009veu.1 uc009veu.2 uc009veu.3 
ENSMUST00000115496.4 Gm20815 ENSMUST00000115496.4 predicted gene, 20815 (from RefSeq NM_001017394.2) ENSMUST00000115496.1 ENSMUST00000115496.2 ENSMUST00000115496.3 Gm20815 J3KMI0 J3KMI0_MOUSE NM_001017394 uc057mcr.1 uc057mcr.2 uc057mcr.3 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc057mcr.1 uc057mcr.2 uc057mcr.3 
ENSMUST00000115498.2 Myot ENSMUST00000115498.2 Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells (By similarity). (from UniProt Q9JIF9) AK017447 ENSMUST00000115498.1 MYOTI_MOUSE Myo Q9JIF9 Ttid uc289ozg.1 uc289ozg.2 Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells (By similarity). Homodimer. Interacts with ACTA1, ACTN1, FLNA, FLNB, FLNC, and MYOZ2. Interacts with the C-terminal region of MYOZ1 (By similarity). Cell membrane, sarcolemma Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line Note=Sarcomeric, also localized to the sarcolemma. Colocalizes with MYOZ1 at the Z-lines in skeletal muscle. Expressed in skeletal muscle (at protein level). No visible phenotype. Mutant mice develop normally, have a normal life span, and their muscle capacity does not significantly differ from wild-type animals, even after prolonged physical stress. Belongs to the myotilin/palladin family. actin binding cytoplasm cytoskeleton plasma membrane homophilic cell adhesion via plasma membrane adhesion molecules axon guidance membrane Z disc axon sarcolemma alpha-actinin binding dendrite self-avoidance protein binding involved in cell-cell adhesion uc289ozg.1 uc289ozg.2 
ENSMUST00000115511.9 Phf14 ENSMUST00000115511.9 PHD finger protein 14, transcript variant 3 (from RefSeq NM_001362122.1) ENSMUST00000115511.1 ENSMUST00000115511.2 ENSMUST00000115511.3 ENSMUST00000115511.4 ENSMUST00000115511.5 ENSMUST00000115511.6 ENSMUST00000115511.7 ENSMUST00000115511.8 NM_001362122 PHF14_MOUSE Q810Z6 Q8C284 Q8CGF8 Q9D1Q8 Q9D4H9 uc009ayg.1 uc009ayg.2 uc009ayg.3 uc009ayg.4 Histone-binding protein (By similarity). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (PubMed:22730381). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (PubMed:33035772). [Isoform 1]: Nucleus Chromosome Note=Mainly localized in the nucleus of interphase cells. In mitotic cells, colocalizes with condensed chromatin during metaphase and anaphase. [Isoform 2]: Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D4H9-2; Sequence=Displayed; Name=2; IsoId=Q9D4H9-1; Sequence=VSP_061649, VSP_061650; Name=3; IsoId=Q9D4H9-3; Sequence=VSP_061648; High levels detected in testis, lung and spleen and low levels in muscle, heart, intestine and kidney (at protein level) (PubMed:23688586). Widely expressed in adult with increased levels in intestine, colon and lung (PubMed:22730381). Expressed throughout embryogenesis and in the adult. The N-terminal region, including the PHD-type 1 and 2 zinc fingers and the C2HC pre-PHD-type zinc finger, is required for binding to histone H3. Death just after birth due to respiratory failure with lungs showing interstitial hyperplasia (PubMed:22730381, PubMed:23688586). Abnormalities are also observed in other organs such as kidney and lung (PubMed:23688586). Mesenchymal fibroblasts exhibit increased proliferation and increased PDGFRA expression (PubMed:22730381). Conditional knockout in germinal center (GC) B cells results in reduced GC response in the spleen following immune challenge, with fewer and smaller GCs observed (PubMed:33035772). Sequence=AAO17166.1; Type=Erroneous gene model prediction; Evidence=; Sequence=BAB22644.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter molecular_function nucleus negative regulation of cell proliferation metal ion binding lung alveolus development negative regulation of mesenchymal cell proliferation negative regulation of platelet-derived growth factor receptor-alpha signaling pathway negative regulation of mesenchymal cell proliferation involved in lung development uc009ayg.1 uc009ayg.2 uc009ayg.3 uc009ayg.4 
ENSMUST00000115513.9 Bcor ENSMUST00000115513.9 BCL6 interacting corepressor, transcript variant a (from RefSeq NM_029510.3) B1AXK3 B1AXK4 B1AXK5 B1AXK6 BCOR_MOUSE ENSMUST00000115513.1 ENSMUST00000115513.2 ENSMUST00000115513.3 ENSMUST00000115513.4 ENSMUST00000115513.5 ENSMUST00000115513.6 ENSMUST00000115513.7 ENSMUST00000115513.8 Kiaa1575 NM_029510 Q6PDK5 Q6ZPM3 Q8BKF5 Q8CGN1 Q8CGN2 Q8CGN3 Q8CGN4 uc009sqq.1 uc009sqq.2 uc009sqq.3 uc009sqq.4 uc009sqq.5 Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA- binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) (By similarity). Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Isoform 1 may interact with MLLT3/AF9 (PubMed:12776190). Interacts with BCL6; the interaction is direct. Forms ternary complexes with BCL6 and SMRT/NCOR2 on selected target genes promoters; potently repress expression. Can interact with HDAC1, HDAC3 and HDAC5. Interacts with PCGF1; the interaction is direct. Interacts with KDM2B. Component of an approximately 800 kDa repressive BCOR complex at least composed of BCOR, RYBP, PCGF1, RING1, RNF2/RING2, KDM2B and SKP1 (By similarity). Q8CGN4; P41183: Bcl6; NbExp=2; IntAct=EBI-1216174, EBI-6253762; Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=A; IsoId=Q8CGN4-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q8CGN4-2; Sequence=VSP_012558; Name=3; Synonyms=C; IsoId=Q8CGN4-3; Sequence=VSP_012559; Name=4; Synonyms=D; IsoId=Q8CGN4-4; Sequence=VSP_012558, VSP_012559; Expressed in heart, liver, lung, skeletal muscle, spleen and testis. Belongs to the BCOR family. Sequence=BAC98208.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter negative regulation of histone H3-K36 methylation RNA polymerase II regulatory region sequence-specific DNA binding blastocyst hatching transcription corepressor activity ubiquitin-protein transferase activity protein binding nucleus chromatin organization heart development transcription factor binding negative regulation of bone mineralization heat shock protein binding histone H2A monoubiquitination odontogenesis histone deacetylase binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated negative regulation of histone H3-K4 methylation palate development specification of axis polarity negative regulation of tooth mineralization uc009sqq.1 uc009sqq.2 uc009sqq.3 uc009sqq.4 uc009sqq.5 
ENSMUST00000115516.11 Zfp13 ENSMUST00000115516.11 zinc finger protein 13, transcript variant 11 (from RefSeq NM_001414212.1) D7F2B3 ENSMUST00000115516.1 ENSMUST00000115516.10 ENSMUST00000115516.2 ENSMUST00000115516.3 ENSMUST00000115516.4 ENSMUST00000115516.5 ENSMUST00000115516.6 ENSMUST00000115516.7 ENSMUST00000115516.8 ENSMUST00000115516.9 Krox-8 NM_001414212 P10754 Q80WS0 Q8CDD0 RHIT_MOUSE Rhit Zfp-13 Zfp13 uc008ash.1 uc008ash.2 uc008ash.3 uc008ash.4 Transcriptional repressor that binds to the promoter region of Mpv17l isoform M-LP short and regulates its age-dependent and heat- induced expression (PubMed:20231359). By regulating Mpv17l expression, contributes to the regulation of genes involved in H(2)O(2) metabolism and the mitochondrial apoptotic cascade (PubMed:20231359) (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P10754-1; Sequence=Displayed; Name=2; IsoId=P10754-2; Sequence=VSP_016902; Expression in the kidney decreases steadily from 3 days until 6 months and then increases slightly at 15 months. Repressed by heat. The KRAB domain is required for transcriptional repression. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus mitochondrion regulation of transcription, DNA-templated positive regulation of hydrogen peroxide biosynthetic process metal ion binding positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway uc008ash.1 uc008ash.2 uc008ash.3 uc008ash.4 
ENSMUST00000115522.10 Eef1akmt4 ENSMUST00000115522.10 EEF1A lysine methyltransferase 4 (from RefSeq NM_025462.2) EFMT4_MOUSE ENSMUST00000115522.1 ENSMUST00000115522.2 ENSMUST00000115522.3 ENSMUST00000115522.4 ENSMUST00000115522.5 ENSMUST00000115522.6 ENSMUST00000115522.7 ENSMUST00000115522.8 ENSMUST00000115522.9 Eef1akmt4 NM_025462 P0DPE0 Q14BY3 Q80Z59 Q80Z60 Q9D8Q9 Q9D928 uc007yqh.1 uc007yqh.2 uc007yqh.3 This gene encodes a member of the lysine-specific methyltransferase (KMT) family. The encoded enzyme catalyzes the methylation of lysine-36 of the eukaryotic translation elongation factor 1 alpha. Methylation by this enzyme may affect endoplasmic reticulum-related processes. [provided by RefSeq, Jul 2017]. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2). Reaction=L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:51736, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13053, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence=; Reaction=N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54196, Rhea:RHEA-COMP:13053, Rhea:RHEA-COMP:13827, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; Reaction=N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54200, Rhea:RHEA-COMP:13826, Rhea:RHEA- COMP:13827, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961, ChEBI:CHEBI:61976; Evidence=; Event=Alternative splicing; Named isoforms=3; Name=Eef1akmt4-1; IsoId=P0DPE0-1, Q80Z60-3; Sequence=Displayed; Name=Eef1akmt4-Ece2-1; Synonyms=ECE-2a-1; IsoId=P0DPD9-1, Q80Z60-1; Sequence=External; Name=Eef1akmt4-Ece2-2; Synonyms=ECE-2a-2; IsoId=P0DPD9-2, Q80Z60-2; Sequence=External; Belongs to the methyltransferase superfamily. Sequence=BAB25257.1; Type=Frameshift; Evidence=; methyltransferase activity protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine methylation methylation uc007yqh.1 uc007yqh.2 uc007yqh.3 
ENSMUST00000115524.8 Mid1ip1 ENSMUST00000115524.8 Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish)), transcript variant 1 (from RefSeq NM_001166635.1) ENSMUST00000115524.1 ENSMUST00000115524.2 ENSMUST00000115524.3 ENSMUST00000115524.4 ENSMUST00000115524.5 ENSMUST00000115524.6 ENSMUST00000115524.7 M1IP1_MOUSE Mig12 NM_001166635 Q8BHT5 Q9CQ20 uc009sqn.1 uc009sqn.2 uc009sqn.3 uc009sqn.4 Plays a role in the regulation of lipogenesis in liver. Up- regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules. Homodimer in the absence of THRSP. Heterodimer with THRSP. The homodimer interacts with ACACA and ACACB. Promotes polymerization of Acetyl-CoA carboxylase to form complexes that contain MID1IP1 and ACACA and/or ACACB. Interaction with THRSP interferes with ACACA binding. Q9CQ20; Q5SWU9: Acaca; NbExp=2; IntAct=EBI-473024, EBI-773043; Q9CQ20; O70583: Mid1; NbExp=8; IntAct=EBI-473024, EBI-472994; Q9CQ20; Q9CQ20: Mid1ip1; NbExp=3; IntAct=EBI-473024, EBI-473024; Q9CQ20; Q13085: ACACA; Xeno; NbExp=4; IntAct=EBI-473024, EBI-717681; Q9CQ20; O00763: ACACB; Xeno; NbExp=4; IntAct=EBI-473024, EBI-2211739; Q9CQ20; G3H9D1: I79_006999; Xeno; NbExp=2; IntAct=EBI-473024, EBI-15884821; Nucleus Cytoplasm Cytoplasm, cytoskeleton Note=Associated with microtubules (PubMed:15070402). During embryonic development, expressed mainly in the neuroepithelial midline, urogenital apparatus and digits. Detected in adult white fat, liver, heart, brain and kidney. Expressed at very low levels in lactating mammary gland. Down-regulated by fasting. Up-regulated by a carbohydrate- rich diet. Belongs to the SPOT14 family. It is uncertain whether Met-1 or Met-2 is the initiator. Sequence=AAP87014.1; Type=Erroneous initiation; Evidence=; protein binding nucleus cytoplasm cytosol cytoskeleton microtubule lipid metabolic process negative regulation of microtubule depolymerization protein C-terminus binding microtubule cytoskeleton identical protein binding positive regulation of fatty acid biosynthetic process regulation of lipid biosynthetic process protein polymerization positive regulation of ligase activity uc009sqn.1 uc009sqn.2 uc009sqn.3 uc009sqn.4 
ENSMUST00000115527.8 Fam133b ENSMUST00000115527.8 family with sequence similarity 133, member B (from RefSeq NM_001042501.1) B2RVR0 ENSMUST00000115527.1 ENSMUST00000115527.2 ENSMUST00000115527.3 ENSMUST00000115527.4 ENSMUST00000115527.5 ENSMUST00000115527.6 ENSMUST00000115527.7 F133B_MOUSE NM_001042501 Q78HY5 Q9CVI2 uc008wgy.1 uc008wgy.2 uc008wgy.3 uc008wgy.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CVI2-1; Sequence=Displayed; Name=2; IsoId=Q9CVI2-2; Sequence=VSP_025572, VSP_025573; [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the FAM133 family. cellular_component biological_process uc008wgy.1 uc008wgy.2 uc008wgy.3 uc008wgy.4 
ENSMUST00000115535.3 Zfp944 ENSMUST00000115535.3 zinc finger protein 944, transcript variant 1 (from RefSeq NM_176962.4) E9PUS4 E9PUS4_MOUSE ENSMUST00000115535.1 ENSMUST00000115535.2 NM_176962 Zfp944 uc008arp.1 uc008arp.2 uc008arp.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008arp.1 uc008arp.2 uc008arp.3 
ENSMUST00000115537.2 Col28a1 ENSMUST00000115537.2 collagen, type XXVIII, alpha 1 (from RefSeq NM_001037865.1) COSA1_MOUSE Col28 ENSMUST00000115537.1 NM_001037865 Q2UY10 Q2UY11 uc009axi.1 uc009axi.2 May act as a cell-binding protein. Trimer or homomer. Secreted into as a 135 kDa monomer under reducing conditions and as a homotrimer under non-reducing conditions. Secreted, extracellular space, extracellular matrix, basement membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2UY11-1; Sequence=Displayed; Name=2; IsoId=Q2UY11-2; Sequence=VSP_031095, VSP_031096; Expressed in skin, intestine, sternum, brain and kidney. Lower expression is also observed in heart, lung, sciatic nerve, dorsal root ganglia, peripheral nerves and calvaria of newborn mice and in intestine and brain of adult mice. Found in basement membrane surrounding a particular subset of Schwann cells in adult sciatic nerve. Major expression in dorsal root ganglia and peripheral nerves, with small amounts in connective tissues like calvaria and skin. Belongs to the VWA-containing collagen family. serine-type endopeptidase inhibitor activity extracellular matrix structural constituent extracellular region collagen trimer basement membrane extracellular space cell adhesion negative regulation of peptidase activity negative regulation of endopeptidase activity extracellular matrix structural constituent conferring tensile strength extracellular matrix organization peptidase inhibitor activity extracellular matrix uc009axi.1 uc009axi.2 
ENSMUST00000115557.10 Zfp846 ENSMUST00000115557.10 zinc finger protein 846 (from RefSeq NM_172919.2) ENSMUST00000115557.1 ENSMUST00000115557.2 ENSMUST00000115557.3 ENSMUST00000115557.4 ENSMUST00000115557.5 ENSMUST00000115557.6 ENSMUST00000115557.7 ENSMUST00000115557.8 ENSMUST00000115557.9 G3X996 G3X996_MOUSE NM_172919 Zfp846 uc009oiw.1 uc009oiw.2 uc009oiw.3 Nucleus nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009oiw.1 uc009oiw.2 uc009oiw.3 
ENSMUST00000115559.10 Dync1i1 ENSMUST00000115559.10 dynein cytoplasmic 1 intermediate chain 1, transcript variant 1 (from RefSeq NM_010063.5) DC1I1_MOUSE Dnci1 Dncic1 ENSMUST00000115559.1 ENSMUST00000115559.2 ENSMUST00000115559.3 ENSMUST00000115559.4 ENSMUST00000115559.5 ENSMUST00000115559.6 ENSMUST00000115559.7 ENSMUST00000115559.8 ENSMUST00000115559.9 NM_010063 O88485 O88486 Q80W09 uc012ehw.1 uc012ehw.2 uc012ehw.3 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non- catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1H1. Interacts with DYNLT1 and DYNLT3. Interacts with DCTN1 (By similarity). Interacts with DYNLL2. O88485; Q64368: Dazl; NbExp=4; IntAct=EBI-492834, EBI-2024439; O88485; P63168: Dynll1; NbExp=2; IntAct=EBI-492834, EBI-349121; O88485; Q61768: Kif5b; NbExp=4; IntAct=EBI-492834, EBI-776129; O88485; P06537: Nr3c1; NbExp=2; IntAct=EBI-492834, EBI-492753; O88485; P42858: HTT; Xeno; NbExp=2; IntAct=EBI-492834, EBI-466029; Cytoplasm Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle pole Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1A; IsoId=O88485-1; Sequence=Displayed; Name=1B; IsoId=O88485-2; Sequence=VSP_001334; Belongs to the dynein intermediate chain family. chromosome, centromeric region kinetochore condensed chromosome kinetochore spindle pole motor activity microtubule motor activity protein binding nucleus chromosome cytoplasm cytoskeleton cytoplasmic dynein complex microtubule microtubule-based movement microtubule binding dynein complex spectrin binding vesicle cytoplasmic ribonucleoprotein granule dynein light chain binding dynein heavy chain binding vesicle transport along microtubule perinuclear region of cytoplasm recycling endosome axon cytoplasm positive regulation of ATP-dependent microtubule motor activity, plus-end-directed piccolo-bassoon transport vesicle ATP-dependent microtubule motor activity, plus-end-directed uc012ehw.1 uc012ehw.2 uc012ehw.3 
ENSMUST00000115560.4 Yeats2 ENSMUST00000115560.4 YEATS domain containing 2, transcript variant 1 (from RefSeq NM_001145930.1) ENSMUST00000115560.1 ENSMUST00000115560.2 ENSMUST00000115560.3 Kiaa1197 NM_001145930 Q3TUF7 Q6PGF8 Q80TI2 Q8CG86 YETS2_MOUSE Yeats2 uc012aco.1 uc012aco.2 uc012aco.3 Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, SGF29 and DR1. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TUF7-1; Sequence=Displayed; Name=2; IsoId=Q3TUF7-2; Sequence=VSP_017007, VSP_017008; Name=3; IsoId=Q3TUF7-3; Sequence=VSP_017006; The YEATS domain specifically recognizes and binds crotonylated histones. Sequence=AAH57045.1; Type=Erroneous initiation; Evidence=; Sequence=BAC65745.3; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it is derived from pre-RNA.; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleus Ada2/Gcn5/Ada3 transcription activator complex regulation of transcription, DNA-templated TBP-class protein binding histone binding histone H3 acetylation negative regulation of transcription, DNA-templated mitotic spindle uc012aco.1 uc012aco.2 uc012aco.3 
ENSMUST00000115561.3 Ssxb16 ENSMUST00000115561.3 Belongs to the SSX family. (from UniProt A2AHC8) A2AHC8 A2AHC8_MOUSE ENSMUST00000115561.1 ENSMUST00000115561.2 Gm5751 Ssxb16 uc292ndv.1 uc292ndv.2 uc292ndv.3 Belongs to the SSX family. nucleic acid binding nucleus regulation of transcription, DNA-templated uc292ndv.1 uc292ndv.2 uc292ndv.3 
ENSMUST00000115563.2 Ssxb14 ENSMUST00000115563.2 SSX member B14 (from RefSeq NM_001081564.1) A2AHC7 A2AHC7_MOUSE ENSMUST00000115563.1 Gm6592 NM_001081564 Ssxb14 uc009sph.1 uc009sph.2 Belongs to the SSX family. nucleic acid binding nucleus regulation of transcription, DNA-templated uc009sph.1 uc009sph.2 
ENSMUST00000115567.8 Nr3c1 ENSMUST00000115567.8 nuclear receptor subfamily 3, group C, member 1, transcript variant 2 (from RefSeq NM_001361209.1) E0ZPU5 E9PUR6 E9PYV1 ENSMUST00000115567.1 ENSMUST00000115567.2 ENSMUST00000115567.3 ENSMUST00000115567.4 ENSMUST00000115567.5 ENSMUST00000115567.6 ENSMUST00000115567.7 GCR_MOUSE Grl Grl1 NM_001361209 P06537 Q06VW2 Q3U126 Q3U2M7 Q61628 Q61629 uc008esx.1 uc008esx.2 uc008esx.3 Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Could act as a coactivator for STAT5- dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546). [Isoform 1]: Has transcriptional activation and repression activity (By similarity). Mediates glucocorticoid-induced apoptosis (By similarity). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (PubMed:21994940). [Isoform 3]: Acts as a dominant negative inhibitor of isoform 1 (PubMed:20660300). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (By similarity). Loses this transcription modulator function on its own (By similarity). Has no hormone-binding activity (PubMed:20660300). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (PubMed:20660300). Reduces hepatic gluconeogenesis through down- regulation of PEPCK in an isoform Alpha-dependent manner (By similarity). Directly regulates STAT1 expression in isoform Alpha- independent manner (By similarity). Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C (PubMed:9195923, PubMed:21994940). Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates (PubMed:9195923, PubMed:11278753). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (By similarity). Directly interacts with UNC45A (By similarity). Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers (PubMed:9528750). Interacts with NRIP1, POU2F1, POU2F2 and TRIM28 (PubMed:9742105). Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6 (By similarity). Interaction with BAG1 inhibits transactivation (By similarity). Interacts with HEXIM1 and TGFB1I1 (PubMed:10848625). Interacts with NCOA1 (By similarity). Interacts with NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity). Interacts with CLOCK, CRY1 and CRY2 in a ligand-dependent fashion (PubMed:22170608, PubMed:28751364). Interacts with CIART (PubMed:24736997). Interacts with RWDD3 (By similarity). Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3 (By similarity). Interacts with GRIP1 (By similarity). Interacts with NR4A3 (via nuclear receptor DNA-binding domain), represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE) (By similarity). Directly interacts with PNRC2 to attract and form a complex with UPF1 and DCP1A; the interaction leads to rapid mRNA degradation (By similarity). Interacts with GSK3B (By similarity). Interacts with FNIP1 and FNIP2 (By similarity). Interacts (via C-terminus) with HNRNPU (via C-terminus) (By similarity). Interacts with MCM3AP (By similarity). Interacts (via domain NR LBD) with HSP90AA1 and HSP90AB1 (PubMed:27686098). In the absence of hormonal ligand, interacts with TACC1 (By similarity). Interacts (via NR LBD domain) with ZNF764 (via KRAB domain); the interaction regulates transcription factor activity of NR3C1 by directing its actions toward certain biologic pathways (By similarity). P06537; O88485: Dync1i1; NbExp=2; IntAct=EBI-492753, EBI-492834; P06537; P30416: Fkbp4; NbExp=3; IntAct=EBI-492753, EBI-492746; P06537; Q64378: Fkbp5; NbExp=2; IntAct=EBI-492753, EBI-492796; P06537; P11499: Hsp90ab1; NbExp=2; IntAct=EBI-492753, EBI-492813; P06537-1; P97784: Cry1; NbExp=3; IntAct=EBI-15959147, EBI-1266607; P06537-1; Q9R194: Cry2; NbExp=3; IntAct=EBI-15959147, EBI-1266619; Cytoplasm cleus Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding (PubMed:11278753). The hormone-occupied receptor undergoes rapid exchange between chromatin and the nucleoplasmic compartment (PubMed:10678832). In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20 (PubMed:27686098). Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20 (PubMed:27686098). [Isoform 1]: Cytoplasm Nucleus Mitochondrion Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=After ligand activation, translocates from the cytoplasm to the nucleus. [Isoform 3]: Nucleus Cytoplasm Note=Expressed predominantly in the nucleus with some expression also detected in the cytoplasm. Event=Alternative splicing, Alternative initiation; Named isoforms=5; Name=1; Synonyms=1-A, GR form A, Alpha; IsoId=P06537-1; Sequence=Displayed; Name=2; Synonyms=2-A, GR form B, Gamma; IsoId=P06537-2; Sequence=VSP_003704; Name=1-B; IsoId=P06537-3; Sequence=VSP_018774; Name=2-B; IsoId=P06537-4; Sequence=VSP_018774, VSP_003704; Name=3; Synonyms=Beta; IsoId=P06537-5; Sequence=VSP_058320, VSP_058321; Expressed in spleen, kidney and liver (PubMed:20660300). Expressed in a circadian manner in the liver (PubMed:27686098). [Isoform 3]: Expressed at highest level in spleen with lesser amounts in kidney and liver. [Isoform 1]: Down-regulated by glucocorticoids. [Isoform 3]: Up-regulated by glucocorticoids and insulin. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The ligand- binding domain is required for correct chromosome segregation during mitosis although ligand binding is not required. Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity. Increased proteasome-mediated degradation in response to glucocorticoids. Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoids. Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-221, Ser-243 and Ser-421-phosphorylated forms are mainly cytoplasmic, and the Ser-229-phosphorylated form is nuclear (By similarity). Phosphorylation at Ser-229 increases transcriptional activity (By similarity). Phosphorylation at Ser-221, Ser-243 and Ser-421 decreases signaling capacity (By similarity). Phosphorylation at Ser-421 may protect from glucocorticoid-induced apoptosis (By similarity). Phosphorylation at Ser-221 and Ser-229 is not required in regulation of chromosome segregation (By similarity). May be dephosphorylated by PPP5C, attenuates NR3C1 action (PubMed:21994940). Sumoylation at Lys-294 and Lys-310 negatively regulates its transcriptional activity. Sumoylation at Lys-718 positively regulates its transcriptional activity in the presence of RWDD3. Sumoylation at Lys-294 and Lys-310 is dispensable whereas sumoylation at Lys-718 is critical for the stimulatory effect of RWDD3 on its transcriptional activity. Heat shock increases sumoylation in a RWDD3-dependent manner. Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling. The poly-Gln region in 78-91 is polymorphic (PubMed:3780669, PubMed:17012242, PubMed:20660300, PubMed:16141072, PubMed:15489334). Polymorphism plays a role in complex mechanisms leading to lower corticosterone response to stress, and may also be associated with decreased locomotive and increased anxiety-type behaviors (PubMed:17012242). T-cell is a critical cellular target of GR, as immune activation in mice lacking GR resulted in significant mortality. This lethal activation is rescued by PTGS2 inhibition but not steroid administration or cytokine neutralization. [Isoform 2]: Produced by alternative splicing. [Isoform 1-B]: Produced by alternative initiation at Met-28 of isoform 1. [Isoform 2-B]: Produced by alternative initiation at Met-28 of isoform 2. Belongs to the nuclear hormone receptor family. NR3 subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II regulatory region DNA binding core promoter binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding glucocorticoid receptor activity steroid binding protein binding nucleus nucleoplasm cytoplasm mitochondrion microtubule organizing center spindle cytosol cytoskeleton regulation of gluconeogenesis chromatin organization chromatin remodeling transcription, DNA-templated regulation of transcription, DNA-templated transcription factor binding glucocorticoid metabolic process zinc ion binding lipid binding regulation of glucose metabolic process positive regulation of glutamate secretion postsynaptic density membrane nuclear speck protein kinase binding adrenal gland development Hsp70 protein binding receptor tyrosine kinase binding heat shock protein binding negative regulation of synaptic plasticity regulation of glucocorticoid biosynthetic process SUMO binding macromolecular complex regulation of cell proliferation hormone binding maternal behavior identical protein binding protein homodimerization activity glucocorticoid receptor signaling pathway neuron projection negative regulation of apoptotic process negative regulation of vascular permeability dendritic spine glucocorticoid mediated signaling pathway positive regulation of neuron apoptotic process sequence-specific DNA binding macromolecular complex binding positive regulation of transcription from RNA polymerase II promoter response to arsenic-containing substance metal ion binding protein heterodimerization activity chromatin-mediated maintenance of transcription Hsp90 protein binding mammary gland duct morphogenesis positive regulation of dendritic spine development positive regulation of cell growth involved in cardiac muscle cell development cellular response to steroid hormone stimulus cellular response to glucocorticoid stimulus cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus glutamatergic synapse postsynaptic density, intracellular component negative regulation of glucocorticoid mediated signaling pathway positive regulation of pri-miRNA transcription from RNA polymerase II promoter steroid hormone binding positive regulation of glucocorticoid receptor signaling pathway uc008esx.1 uc008esx.2 uc008esx.3 
ENSMUST00000115573.3 Ssxb15 ENSMUST00000115573.3 SSX member B15 (from RefSeq NM_001126491.1) A2BI73 A2BI73_MOUSE ENSMUST00000115573.1 ENSMUST00000115573.2 Gm14459 NM_001126491 Ssxb15 uc012her.1 uc012her.2 uc012her.3 Belongs to the SSX family. nucleic acid binding nucleus regulation of transcription, DNA-templated uc012her.1 uc012her.2 uc012her.3 
ENSMUST00000115576.3 Lix1 ENSMUST00000115576.3 limb and CNS expressed 1 (from RefSeq NM_025681.2) ENSMUST00000115576.1 ENSMUST00000115576.2 LIX1_MOUSE NM_025681 Q6P566 Q8VHY1 Q9CYH4 uc008apg.1 uc008apg.2 uc008apg.3 uc008apg.4 uc008apg.5 Belongs to the LIX1 family. Sequence=BAB30873.1; Type=Frameshift; Evidence=; molecular_function cytoplasm autophagy autophagosome maturation uc008apg.1 uc008apg.2 uc008apg.3 uc008apg.4 uc008apg.5 
ENSMUST00000115577.9 Sgce ENSMUST00000115577.9 sarcoglycan, epsilon, transcript variant 6 (from RefSeq NM_001410332.1) ENSMUST00000115577.1 ENSMUST00000115577.2 ENSMUST00000115577.3 ENSMUST00000115577.4 ENSMUST00000115577.5 ENSMUST00000115577.6 ENSMUST00000115577.7 ENSMUST00000115577.8 NM_001410332 O70258 Q921G2 SGCE_MOUSE uc009avq.1 uc009avq.2 uc009avq.3 uc009avq.4 Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Cell membrane, sarcolemma ; Single-pass membrane protein Golgi apparatus Cell projection, dendrite Cytoplasm, cytoskeleton Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O70258-1; Sequence=Displayed; Name=2; IsoId=O70258-2; Sequence=VSP_006019; Identified in all tissues tested. Expression highest in lung and placenta, moderate in brain, heart and skeletal muscle, low in kidney and liver. Also detected in embryo. N-glycosylated. Ubiquitinated, leading to its degradation by the proteasome. Belongs to the sarcoglycan alpha/epsilon family. Sequence=AAC14020.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH12665.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC36184.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding cytoplasm Golgi apparatus cytoskeleton plasma membrane integral component of plasma membrane dystrophin-associated glycoprotein complex sarcoglycan complex membrane integral component of membrane dendrite dendrite membrane sarcolemma cell projection uc009avq.1 uc009avq.2 uc009avq.3 uc009avq.4 
ENSMUST00000115578.10 Ufd1 ENSMUST00000115578.10 Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1- VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (By similarity). (from UniProt P70362) AK147138 ENSMUST00000115578.1 ENSMUST00000115578.2 ENSMUST00000115578.3 ENSMUST00000115578.4 ENSMUST00000115578.5 ENSMUST00000115578.6 ENSMUST00000115578.7 ENSMUST00000115578.8 ENSMUST00000115578.9 P70362 Q923C4 UFD1_MOUSE Ufd1 Ufd1l uc289dfl.1 uc289dfl.2 Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1- VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (By similarity). Protein degradation; proteasomal ubiquitin-dependent pathway. Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion. Interacts with USP13 (By similarity). Interacts with ZFAND2B; probably through VCP (PubMed:24160817). P70362; Q01853: Vcp; NbExp=9; IntAct=EBI-7961331, EBI-80597; P70362; Q9ES54: Nploc4; Xeno; NbExp=18; IntAct=EBI-7961331, EBI-1993990; Nucleus Cytoplasm, cytosol Expressed at high levels in the otocyst (between 9.5 dpc and 11.5 dpc embryos fading away after 12 dpc) and in the developing eye. Lower expression is found in different sites of the embryos such as developing brain, the lungs and the cardiac outflow tract. Belongs to the UFD1 family. receptor binding protein binding nucleus cytoplasm endoplasmic reticulum cytosol ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol negative regulation of type I interferon production VCP-NPL4-UFD1 AAA ATPase complex K48-linked polyubiquitin binding UFD1-NPL4 complex negative regulation of RIG-I signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process macromolecular complex binding ATPase binding ER-associated misfolded protein catabolic process uc289dfl.1 uc289dfl.2 
ENSMUST00000115580.3 Gm5820 ENSMUST00000115580.3 Gm5820 (from geneSymbol) AK145364 ENSMUST00000115580.1 ENSMUST00000115580.2 uc289oxj.1 uc289oxj.2 uc289oxj.3 uc289oxj.1 uc289oxj.2 uc289oxj.3 
ENSMUST00000115584.3 Ssxb9 ENSMUST00000115584.3 SSX member B9 (from RefSeq NM_199066.2) ENSMUST00000115584.1 ENSMUST00000115584.2 NM_199066 Q6XAR8 Q6XAR8_MOUSE Ssxb9 uc012hep.1 uc012hep.2 uc012hep.3 uc012hep.4 Belongs to the SSX family. nucleic acid binding nucleus regulation of transcription, DNA-templated uc012hep.1 uc012hep.2 uc012hep.3 uc012hep.4 
ENSMUST00000115591.8 Slc38a5 ENSMUST00000115591.8 Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:15489334, PubMed:16249471). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate- glutamine cycle (PubMed:15489334, PubMed:16249471). The transport activity is pH sensitive, Li(+) tolerant, bidirectional and associated with large uncoupled fluxes of protons (By similarity). Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity). (from UniProt Q3U1J0) AK158125 ENSMUST00000115591.1 ENSMUST00000115591.2 ENSMUST00000115591.3 ENSMUST00000115591.4 ENSMUST00000115591.5 ENSMUST00000115591.6 ENSMUST00000115591.7 Jm24 Q3TZ39 Q3U1J0 Q8BJZ6 Q8BW30 S38A5_MOUSE Slc38a5 Sn2 Snat5 uc292ndn.1 uc292ndn.2 Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:15489334, PubMed:16249471). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate- glutamine cycle (PubMed:15489334, PubMed:16249471). The transport activity is pH sensitive, Li(+) tolerant, bidirectional and associated with large uncoupled fluxes of protons (By similarity). Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity). Reaction=H(+)(in) + L-glutamine(out) + Na(+)(out) = H(+)(out) + L- glutamine(in) + Na(+)(in); Xref=Rhea:RHEA:71127, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:58359; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71128; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71129; Evidence=; Reaction=H(+)(in) + L-serine(out) + Na(+)(out) = H(+)(out) + L- serine(in) + Na(+)(in); Xref=Rhea:RHEA:71159, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71160; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71161; Evidence=; Reaction=H(+)(in) + L-alanine(out) + Na(+)(out) = H(+)(out) + L- alanine(in) + Na(+)(in); Xref=Rhea:RHEA:71163, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:57972; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71164; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71165; Evidence=; Reaction=glycine(out) + H(+)(in) + Na(+)(out) = glycine(in) + H(+)(out) + Na(+)(in); Xref=Rhea:RHEA:71167, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:57305; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71168; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71169; Evidence=; Reaction=H(+)(in) + L-asparagine(out) + Na(+)(out) = H(+)(out) + L- asparagine(in) + Na(+)(in); Xref=Rhea:RHEA:71131, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:58048; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71132; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71133; Evidence=; Reaction=H(+)(in) + L-histidine(out) + Na(+)(out) = H(+)(out) + L- histidine(in) + Na(+)(in); Xref=Rhea:RHEA:71135, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:57595; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71136; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71137; Evidence=; Reaction=H(+)(in) + L-cysteine(out) + Na(+)(out) = H(+)(out) + L- cysteine(in) + Na(+)(in); Xref=Rhea:RHEA:71171, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:35235; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71172; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71173; Evidence=; Not inhibited by lithium (By similarity). Partial allosteric regulation on ions sodium binding (By similarity). Cell membrane ; Multi-pass membrane protein Note=Localized at astroglial membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U1J0-1; Sequence=Displayed; Name=2; IsoId=Q3U1J0-2; Sequence=VSP_029703; Expressed in the ganglion cell layer and the nerve fiber layer (at protein level) (PubMed:18689705). Also expreseed in the cells of the inner nuclear layer and in the inner plexiform layer (at protein level) (PubMed:18689705). Expressed in Mueller and ganglion retinal cell (PubMed:18689705). Down-regulated in Dgn3 deficient mice. Belongs to the amino acid/polyamine transporter 2 family. Nakanishi et al (PMID:11698233) shows that the transport process is electrogenic, contrary to the conclusions of Hamdani et al (PMID:22821889) who finds that the transport is electroneutral with a Na(+):L-glutamine stoichiometry of 1:1 (By similarity). Hamdani et al. shows that this electrogenic transport describes by Nakanishi et al. would correspond to large uncoupled fluxes of protons (By similarity). Sequence=BAC35799.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; amino acid transmembrane transport plasma membrane integral component of plasma membrane amino acid transmembrane transporter activity neutral amino acid transmembrane transporter activity glycine transmembrane transporter activity neutral amino acid transport glycine transport membrane integral component of membrane uc292ndn.1 uc292ndn.2 
ENSMUST00000115609.10 Comt ENSMUST00000115609.10 catechol-O-methyltransferase, transcript variant 2 (from RefSeq NM_007744.3) COMT_MOUSE Comt Comt1 ENSMUST00000115609.1 ENSMUST00000115609.2 ENSMUST00000115609.3 ENSMUST00000115609.4 ENSMUST00000115609.5 ENSMUST00000115609.6 ENSMUST00000115609.7 ENSMUST00000115609.8 ENSMUST00000115609.9 NM_007744 O88587 Q91XH4 uc007ynu.1 uc007ynu.2 uc007ynu.3 uc007ynu.4 Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Reaction=a catechol + S-adenosyl-L-methionine = a guaiacol + H(+) + S- adenosyl-L-homocysteine; Xref=Rhea:RHEA:17877, ChEBI:CHEBI:15378, ChEBI:CHEBI:33566, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:134251; EC=2.1.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17878; Evidence=; Reaction=2-hydroxyestrone + S-adenosyl-L-methionine = 2-hydroxy-3- methoxy-estrone + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:53108, ChEBI:CHEBI:1156, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:136980; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53109; Evidence=; Reaction=4-hydroxyestrone + S-adenosyl-L-methionine = 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:53104, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:87602, ChEBI:CHEBI:136972; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53105; Evidence=; Reaction=2-hydroxyestrone + S-adenosyl-L-methionine = 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:53100, ChEBI:CHEBI:1156, ChEBI:CHEBI:1189, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53101; Evidence=; Reaction=4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4- methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:53096, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:62845, ChEBI:CHEBI:136975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53097; Evidence=; Reaction=2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2- hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:53092, ChEBI:CHEBI:15378, ChEBI:CHEBI:28744, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:89268; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53093; Evidence=; Reaction=2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2- methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:53088, ChEBI:CHEBI:15378, ChEBI:CHEBI:28744, ChEBI:CHEBI:28955, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53089; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; [Isoform Soluble]: Cytoplasm [Isoform Membrane-bound]: Cell membrane ; Single-pass type II membrane protein ; Extracellular side Event=Alternative initiation; Named isoforms=2; Name=Membrane-bound; Synonyms=MB-COMT; IsoId=O88587-1; Sequence=Displayed; Name=Soluble; Synonyms=S-COMT; IsoId=O88587-2; Sequence=VSP_018779; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. magnesium ion binding cytoplasm mitochondrion cytosol plasma membrane catecholamine metabolic process female pregnancy learning short-term memory methyltransferase activity O-methyltransferase activity estrogen metabolic process catechol-containing compound metabolic process response to organic cyclic compound membrane integral component of membrane cellular response to phosphate starvation catechol O-methyltransferase activity transferase activity axon dendrite methylation response to lipopolysaccharide developmental process negative regulation of renal sodium excretion neurotransmitter catabolic process dopamine metabolic process dopamine catabolic process catecholamine catabolic process response to drug dendritic spine intracellular membrane-bounded organelle response to estrogen cell body postsynaptic membrane negative regulation of dopamine metabolic process metal ion binding response to pain multicellular organismal reproductive process negative regulation of smooth muscle cell proliferation positive regulation of homocysteine metabolic process regulation of sensory perception of pain uc007ynu.1 uc007ynu.2 uc007ynu.3 uc007ynu.4 
ENSMUST00000115619.8 Rbm3 ENSMUST00000115619.8 Cytoplasm (from UniProt Q545K5) AK049575 ENSMUST00000115619.1 ENSMUST00000115619.2 ENSMUST00000115619.3 ENSMUST00000115619.4 ENSMUST00000115619.5 ENSMUST00000115619.6 ENSMUST00000115619.7 Q545K5 Q545K5_MOUSE RBM3 Rbm3 uc292nct.1 uc292nct.2 Cytoplasm nucleic acid binding RNA binding uc292nct.1 uc292nct.2 
ENSMUST00000115622.8 Calcr ENSMUST00000115622.8 calcitonin receptor, transcript variant 3 (from RefSeq NM_001355192.1) CALCR_MOUSE Calcr ENSMUST00000115622.1 ENSMUST00000115622.2 ENSMUST00000115622.3 ENSMUST00000115622.4 ENSMUST00000115622.5 ENSMUST00000115622.6 ENSMUST00000115622.7 F6X7J4 NM_001355192 Q3UUL9 Q60755 Q8CAB0 uc009avg.1 uc009avg.2 uc009avg.3 This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Interacts with GPRASP2. Cell membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60755-1; Sequence=Displayed; Name=2; IsoId=Q60755-2; Sequence=VSP_053294; Belongs to the G-protein coupled receptor 2 family. Sequence=AAA69521.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; calcitonin gene-related peptide receptor activity acrosomal vesicle transmembrane signaling receptor activity G-protein coupled receptor activity calcitonin receptor activity plasma membrane cilium signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of gene expression positive regulation of protein kinase A signaling positive regulation of cell death membrane integral component of membrane negative regulation of ossification osteoclast differentiation axon calcitonin binding positive regulation of peptidyl-serine phosphorylation cross-receptor inhibition within G-protein coupled receptor heterodimer neuron projection neuronal cell body regulation of mRNA stability positive regulation of adenylate cyclase activity response to glucocorticoid positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade amylin receptor activity amylin receptor signaling pathway response to beta-amyloid positive regulation of calcium ion import across plasma membrane uc009avg.1 uc009avg.2 uc009avg.3 
ENSMUST00000115628.10 Tango2 ENSMUST00000115628.10 transport and golgi organization 2, transcript variant 1 (from RefSeq NM_138583.2) D16H22S680E ENSMUST00000115628.1 ENSMUST00000115628.2 ENSMUST00000115628.3 ENSMUST00000115628.4 ENSMUST00000115628.5 ENSMUST00000115628.6 ENSMUST00000115628.7 ENSMUST00000115628.8 ENSMUST00000115628.9 NM_138583 P54797 Q8BTN3 T10 TNG2_MOUSE uc007ynk.1 uc007ynk.2 uc007ynk.3 uc007ynk.4 May be involved in lipid homeostasis. Cytoplasm Mitochondrion Golgi apparatus Expressed in fetal liver, lung, heart and kidney (PubMed:8268909). In brain, detected in the olfactory bulb, neocortex and cerebellum (PubMed:18775783). Elevated in mitral cells and minimally expressed in bulb interneurons (PubMed:18775783). In the cortex, restricted to the upper portion of layer 5 (PubMed:18775783). In the cerebellum, excluded from Purkinje cells but expressed in granule cells (PubMed:18775783). Levels increase during embryonic development, drop at postnatal day 0 and increase again during postnatal development, reaching a mmaxium at postnatal day 21 before dropping slightly at postnatal day 60 (PubMed:18775783). In 13 dpc embryos, expressed at high levels in the trachea, liver, esophagus, lung and velo-pharyngeal region (PubMed:8268909). Also detected in the central nervous system (PubMed:8268909). Belongs to the Tango2 family. Previous published data showed conflicting results on the intracellular location of TANGO2. Has been reported to be located in the Golgi apparatus (By similarity). However, another study was unable to detect Golgi localization (By similarity). Has been reported to be located in the mitochondrion by several recent studies in mouse and human (PubMed:18775783). However, no mitochondrial localization was detected in another study which reported that the protein is primarily cytoplasmic (By similarity). molecular_function mitochondrion Golgi apparatus Golgi organization protein secretion uc007ynk.1 uc007ynk.2 uc007ynk.3 uc007ynk.4 
ENSMUST00000115634.8 Diaph1 ENSMUST00000115634.8 diaphanous related formin 1, transcript variant 2 (from RefSeq NM_007858.4) DIAP1_MOUSE Diap1 ENSMUST00000115634.1 ENSMUST00000115634.2 ENSMUST00000115634.3 ENSMUST00000115634.4 ENSMUST00000115634.5 ENSMUST00000115634.6 ENSMUST00000115634.7 NM_007858 O08808 uc033hgl.1 uc033hgl.2 uc033hgl.3 uc033hgl.4 This gene encodes a member of the formin family of proteins that play important roles in cytoskeletal rearragnement by nucleation of actin filaments. Mice lacking the encoded protein develop age-dependent myeloproliferative defects resembling human myeloproliferative syndrome and myelodysplastic syndromes. Trafficking of T lymphocytes to secondary lymphoid organs and egression of thymocytes from the thymus are impaired in these animals. Lack of the encoded protein in T lymphocytes and thymocytes also reduces chemotaxis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2016]. Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (PubMed:10678165, PubMed:15044801, PubMed:18572016, PubMed:23558171). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (PubMed:10678165, PubMed:15044801, PubMed:18572016). Required for cytokinesis, and transcriptional activation of the serum response factor (PubMed:10678165, PubMed:15044801, PubMed:18572016). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (PubMed:10678165, PubMed:15044801, PubMed:18572016). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (PubMed:15311282). Has neurite outgrowth promoting activity (PubMed:10678165, PubMed:15044801, PubMed:18572016). Acts in a Rho-dependent manner to recruit PFY1 to the membrane (PubMed:9214622). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (By similarity). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required in the control of cell shape (By similarity). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF- MRTFA activity (PubMed:23558171). Homodimer (PubMed:14992721, PubMed:15864301). Interacts with the GTP-bound form of RHOA (PubMed:9214622). Interacts with RHOC, PFY1, MAPRE1, BAIAP2 and APC (PubMed:10814512, PubMed:15311282, PubMed:15864301). Interacts with APC; acts as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (PubMed:15311282). Interacts with SCAI (PubMed:19350017). Interacts with DCAF7, via FH2 domain (By similarity). Interacts with NCDN (PubMed:18572016). Interacts with OSBPL10, OSBPL2, VIM, TUBB and DYN1 (By similarity). O08808; Q8BKX1: Baiap2; NbExp=3; IntAct=EBI-1026445, EBI-771498; O08808; O08808: Diaph1; NbExp=9; IntAct=EBI-1026445, EBI-1026445; O08808; P46940: IQGAP1; Xeno; NbExp=8; IntAct=EBI-1026445, EBI-297509; O08808; P61586: RHOA; Xeno; NbExp=3; IntAct=EBI-1026445, EBI-446668; Cell membrane Cell projection, ruffle membrane Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm Nucleus Note=Membrane ruffles, especially at the tip of ruffles, of motile cells. Widely expressed. In the organ of Corti, it is expressed at the outer and inner hair cell layers. Expression at the inner hair cell layer is restricted to inner pillar cells. Detected in cochlear spiral ganglion neurons (PubMed:27808407). Expressed in the ventricular and subventricular zone progenitor cells of the dorsal and ventral forebrain and the brainstem, at 12.5 dpc, 14.5 dpc, and 17.5 dpc. At later embryonic age, it is observed in neurons of the cortex and hippocampus. During postnatal development, expression is detected in the cerebral cortex, basal ganglia, hippocampus, thalamus, and external granular layer of the cerebellum. The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments. Phosphorylation at Thr-751 is stimulated by cAMP and regulates stability, complex formation and mitochondrial movement (By similarity). Knockout mice show normal organization of the cerebral cortex with no significant differences in cortical white matter or callosal thickness (PubMed:24781755). Histological analysis of coronal brain sections at early and postnatal stages shows unilateral ventricular enlargement (PubMed:24781755). Belongs to the formin homology family. Diaphanous subfamily. actin binding protein binding profilin binding nucleus cytoplasm microtubule organizing center spindle cytoskeleton plasma membrane brush border cytoskeleton organization actin filament organization brain development sensory perception of sound regulation of cell shape membrane cellular component organization Rho GTPase binding actin cytoskeleton organization actin filament polymerization positive regulation of cell migration neuron projection development ruffle membrane regulation of microtubule-based process protein localization to microtubule identical protein binding cell projection neuron projection ion channel binding regulation of release of sequestered calcium ion into cytosol regulation of cytoskeleton organization cellular response to histamine mitotic spindle uc033hgl.1 uc033hgl.2 uc033hgl.3 uc033hgl.4 
ENSMUST00000115638.10 Suv39h1 ENSMUST00000115638.10 suppressor of variegation 3-9 1, transcript variant 1 (from RefSeq NM_011514.3) ENSMUST00000115638.1 ENSMUST00000115638.2 ENSMUST00000115638.3 ENSMUST00000115638.4 ENSMUST00000115638.5 ENSMUST00000115638.6 ENSMUST00000115638.7 ENSMUST00000115638.8 ENSMUST00000115638.9 NM_011514 O54864 Q3TEW2 Q3UT51 Q8C2L3 Q9JLC7 Q9JLP8 SUV91_MOUSE Suv39h uc009snq.1 uc009snq.2 uc009snq.3 Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin- like repressive state through H3 'Lys-9' trimethylation. Reaction=L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60276, Rhea:RHEA-COMP:15538, Rhea:RHEA- COMP:15546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.355; Evidence= Negatively regulated by CCAR2. Interacts with CCAR2 and GFI1B. Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8 (By similarity). Interacts with H3 and H4 histones. Interacts with DNMT3B, CBX1, CBX4, MBD1, RUNX1, RUNX3, MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through the N-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. Interacts (via SET domain) with MECOM; enhances MECOM transcriptional repression activity. Interacts with LMNA; the interaction increases stability of SUV39H1. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex. O54864; O70237: Gfi1b; NbExp=2; IntAct=EBI-302230, EBI-4287943; O54864; P10085: Myod1; NbExp=3; IntAct=EBI-302230, EBI-4405734; Nucleus Nucleus lamina Nucleus, nucleoplasm Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O54864-1; Sequence=Displayed; Name=2; IsoId=O54864-2; Sequence=VSP_002208; Name=3; IsoId=O54864-3; Sequence=VSP_024029, VSP_024030; Widely expressed. Expression present throughout embryogenesis. Higher expression between 9.5 dpc and 13 dpc. Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin. In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster. Phosphorylated on serine residues, and to a lesser degree, on threonine residues. Acetylated at Lys-266, leading to inhibition of enzyme activity. SIRT1-mediated deacetylation relieves this inhibition (By similarity). Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation. Mice lacking Suv39h1 and Suv39h2 display severely impaired viability and chromosomal instabilities that are associated with an increased tumor risk and perturbed chromosome interactions during male meiosis. They also show a higher level of histone H3 with phosphorylated 'Ser-10' and a reduced number of cells in G1 phase and an increased portion of cells with aberrant nuclear morphologies. [Isoform 2]: Incomplete sequence. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. [Isoform 2]: Sequence=AAF60970.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter chromatin silencing at rDNA chromosome, centromeric region heterochromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding blastocyst hatching protein binding nucleus nuclear lamina nucleoplasm chromatin silencing complex chromosome nuclear heterochromatin regulation of DNA repair DNA packaging chromatin organization chromatin silencing rRNA processing cellular response to DNA damage stimulus cell cycle methyltransferase activity zinc ion binding protein methyltransferase activity determination of adult lifespan S-adenosylmethionine-dependent methyltransferase activity transferase activity histone-lysine N-methyltransferase activity cell differentiation regulation of bone mineralization methylation rDNA heterochromatin histone lysine methylation histone H3-K9 dimethylation histone H3-K9 trimethylation regulation of multicellular organism growth histone methyltransferase activity negative regulation of circadian rhythm negative regulation of transcription, DNA-templated metal ion binding histone methyltransferase activity (H3-K9 specific) protein N-terminus binding rhythmic process histone H3-K9 methylation cellular response to hypoxia positive regulation of histone H3-K9 trimethylation regulation of cellular senescence uc009snq.1 uc009snq.2 uc009snq.3 
ENSMUST00000115642.8 Hdac6 ENSMUST00000115642.8 histone deacetylase 6, transcript variant 9 (from RefSeq NR_177434.1) B1AUA6 ENSMUST00000115642.1 ENSMUST00000115642.2 ENSMUST00000115642.3 ENSMUST00000115642.4 ENSMUST00000115642.5 ENSMUST00000115642.6 ENSMUST00000115642.7 HDAC6_MOUSE Hdac6 NR_177434 Q9Z2V5 uc009snj.1 uc009snj.2 uc009snj.3 uc009snj.4 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:9891014). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:9891014). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:9891014). In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:19893491, PubMed:27737934). Required for cilia disassembly; via deacetylation of alpha-tubulin (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (By similarity). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (PubMed:35922041). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin- proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (By similarity). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed:22819792). Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA- COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58197; Evidence=; Reaction=H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] = acetate + L-lysyl- [alpha-tubulin]; Xref=Rhea:RHEA:21548, Rhea:RHEA-COMP:11278, Rhea:RHEA-COMP:11279, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21549; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit. ; Interacts with SIRT2 (via both phosphorylated, unphosphorylated, active or inactive forms); the interaction is necessary for the complex to interact with alpha-tubulin (By similarity). Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions (By similarity). Interacts with BBIP1, CBFA2T3, CYLD, DDIT3/CHOP, ZMYND15, F-actin and HDAC11 (PubMed:11533236, PubMed:19893491, PubMed:20675388). Interacts with RIPOR2; this interaction occurs during early myogenic differentiation and prevents HDAC6 to deacetylate tubulin (By similarity). Interacts with AURKA; AURKA-mediated phosphorylation of HDAC6 promotes deacetylation of alpha-tubulin (By similarity). Interacts with DYSF; this interaction occurs during early myogenic differentiation (By similarity). Interacts with TPPP; inhibiting the tubulin deacetylase activity of HDAC6 (By similarity). Interacts with DYNLL1 (By similarity). Interacts with ATP13A2; the interaction results in recruitment of HDAC6 to lysosomes to promote CTTN deacetylation (By similarity). Interacts with CCDC141 (via the N-terminal region); inhibiting the deacetylase activity of HDAC6 (PubMed:27737934). Interacts with IPO7; the interaction facilitates HDAC6 nuclear translocation in dental papilla cells (PubMed:35922041). Q9Z2V5; P31750: Akt1; NbExp=2; IntAct=EBI-1009256, EBI-298707; Q9Z2V5; Q80TQ2: Cyld; NbExp=3; IntAct=EBI-1009256, EBI-943859; Q9Z2V5; Q99N13: Hdac9; NbExp=2; IntAct=EBI-1009256, EBI-645361; Q9Z2V5; O55131: Septin7; NbExp=3; IntAct=EBI-1009256, EBI-772161; Q9Z2V5; D3ZEY0: Ccdc141; Xeno; NbExp=3; IntAct=EBI-1009256, EBI-21448776; Q9Z2V5; P21146: GRK2; Xeno; NbExp=2; IntAct=EBI-1009256, EBI-1036401; Q9Z2V5; P62973; Xeno; NbExp=2; IntAct=EBI-1009256, EBI-16124826; Cytoplasm toplasm, cytoskeleton Nucleus rikaryon Cell projection, dendrite Cell projection, axon Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body Note=It is mainly cytoplasmic, where it is associated with microtubules. Expressed in neurons of the cortex. Expressed in Purkinje cells. Detected in keratinocytes (at protein level). Phosphorylated by AURKA; phosphorylation increases HDAC6-mediated deacetylation of alpha-tubulin and subsequent disassembly of cilia. Ubiquitinated. Its polyubiquitination however does not lead to its degradation. Sumoylated in vitro. Belongs to the histone deacetylase family. HD type 2 subfamily. histone deacetylase complex protein polyubiquitination RNA polymerase II core promoter proximal region sequence-specific DNA binding actin binding histone deacetylase activity protein binding nucleus nucleoplasm cytoplasm centrosome cytosol microtubule microtubule associated complex caveola chromatin organization protein deacetylation ubiquitin-dependent protein catabolic process misfolded or incompletely synthesized protein catabolic process intracellular protein transport negative regulation of microtubule depolymerization beta-catenin binding microtubule binding zinc ion binding response to toxic substance positive regulation of signal transduction response to organic substance regulation of receptor activity positive regulation of epithelial cell migration positive regulation of receptor biosynthetic process inclusion body aggresome regulation of macroautophagy histone deacetylation hydrolase activity deacetylase activity dynein complex axon dendrite cell leading edge negative regulation of protein complex assembly polyubiquitin binding ubiquitin protein ligase binding regulation of protein stability NAD-dependent histone deacetylase activity (H3-K14 specific) lysosome localization positive regulation of protein oligomerization macromolecular complex disassembly macromolecular complex positive regulation of peptidyl-serine phosphorylation protein deacetylase activity peptidyl-lysine deacetylation cellular response to topologically incorrect protein regulation of gene expression, epigenetic histone deacetylase binding tubulin deacetylase activity cell projection neuron projection alpha-tubulin binding ubiquitin binding ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway perikaryon negative regulation of protein complex disassembly cell body regulation of fat cell differentiation negative regulation of proteolysis metal ion binding tau protein binding perinuclear region of cytoplasm beta-tubulin binding collateral sprouting mitochondrion localization misfolded protein binding response to misfolded protein Hsp90 protein binding dendritic spine morphogenesis parkin-mediated mitophagy in response to mitochondrial depolarization regulation of establishment of protein localization cellular response to hydrogen peroxide dynein complex binding aggresome assembly polyubiquitinated misfolded protein transport Hsp90 deacetylation response to growth factor histone H3 deacetylation cellular response to misfolded protein positive regulation of chaperone-mediated protein complex assembly tubulin deacetylation mitophagy in response to mitochondrial depolarization positive regulation of hydrogen peroxide-mediated programmed cell death cytoplasmic microtubule acetylspermidine deacetylase activity uc009snj.1 uc009snj.2 uc009snj.3 uc009snj.4 
ENSMUST00000115644.10 Piwil4 ENSMUST00000115644.10 piwi-like RNA-mediated gene silencing 4, transcript variant 2 (from RefSeq NM_001368832.1) A0A6Q6QBZ6 A0A6Q6QBZ6_MOUSE ENSMUST00000115644.1 ENSMUST00000115644.2 ENSMUST00000115644.3 ENSMUST00000115644.4 ENSMUST00000115644.5 ENSMUST00000115644.6 ENSMUST00000115644.7 ENSMUST00000115644.8 ENSMUST00000115644.9 NM_001368832 Piwil4 uc292enu.1 uc292enu.2 Belongs to the argonaute family. uc292enu.1 uc292enu.2 
ENSMUST00000115645.10 Ranbp1 ENSMUST00000115645.10 RAN binding protein 1 (from RefSeq NM_011239.2) ENSMUST00000115645.1 ENSMUST00000115645.2 ENSMUST00000115645.3 ENSMUST00000115645.4 ENSMUST00000115645.5 ENSMUST00000115645.6 ENSMUST00000115645.7 ENSMUST00000115645.8 ENSMUST00000115645.9 Htf9-a Htf9a NM_011239 P34022 P34023 Q3TL81 Q9D894 Q9DCA3 RANG_MOUSE uc007ymy.1 uc007ymy.2 uc007ymy.3 Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (PubMed:9428644). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (PubMed:9428644). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (By similarity). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:9428644). Inhibits RCC1- dependent exchange of RAN-bound GDP by GTP (By similarity). Interacts with RAN (via C-terminus of GTP-bound form) but not with GDP-bound RAN (PubMed:8255297, PubMed:7891706, PubMed:8896452). Identified in a complex composed of RAN, RANGAP1 and RANBP1 (By similarity). Identified in a complex that contains TNPO1, RAN and RANBP1 (PubMed:9428644). Identified in a complex that contains CSE1L, KPNA2, RAN and RANBP1 (PubMed:9428644). Identified in a complex with nucleotide-free RAN and RCC1 (By similarity). Htf9a (RanBP1) and Htf9c are transcribed with opposite polarity from complementary DNA strands from a shared bidirectional TATA-less promoter. Belongs to the RANBP1 family. GDP-dissociation inhibitor activity GTPase activator activity nucleus nuclear pore cytoplasm centrosome cytosol spindle organization Ran GTPase binding positive regulation of neuron projection development cell projection cytoplasm cellular response to drug positive regulation of GTPase activity positive regulation of mitotic centrosome separation intracellular transport regulation of catalytic activity response to calcium ion cellular response to leptomycin B axon cytoplasm uc007ymy.1 uc007ymy.2 uc007ymy.3 
ENSMUST00000115657.10 Pcdha11 ENSMUST00000115657.10 protocadherin alpha 11 (from RefSeq NM_009960.1) ENSMUST00000115657.1 ENSMUST00000115657.2 ENSMUST00000115657.3 ENSMUST00000115657.4 ENSMUST00000115657.5 ENSMUST00000115657.6 ENSMUST00000115657.7 ENSMUST00000115657.8 ENSMUST00000115657.9 NM_009960 Pcdha11 Q91Y19 Q91Y19_MOUSE uc008eph.1 uc008eph.2 uc008eph.3 uc008eph.4 uc008eph.5 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eph.1 uc008eph.2 uc008eph.3 uc008eph.4 uc008eph.5 
ENSMUST00000115658.6 Pcdha10 ENSMUST00000115658.6 protocadherin alpha 10 (from RefSeq NM_009961.1) ENSMUST00000115658.1 ENSMUST00000115658.2 ENSMUST00000115658.3 ENSMUST00000115658.4 ENSMUST00000115658.5 NM_009961 PCDAA_MOUSE Pcdha10 Q91Y20 uc008epf.1 uc008epf.2 uc008epf.3 uc008epf.4 uc008epf.5 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein The protocadherins alpha are expressed from a single gene cluster similarly to immunoglobulin and T-cell receptors. The N- terminal region containing the 6 extracellular cadherin domains, unique to each protocadherin alpha, is encoded by one of the large exons found in tandem array within the gene cluster. The C-terminal region, identical to all protocadherins alpha, is encoded by 3 shared exons. calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epf.1 uc008epf.2 uc008epf.3 uc008epf.4 uc008epf.5 
ENSMUST00000115659.6 Pcdha9 ENSMUST00000115659.6 protocadherin alpha 9 (from RefSeq NM_138661.1) ENSMUST00000115659.1 ENSMUST00000115659.2 ENSMUST00000115659.3 ENSMUST00000115659.4 ENSMUST00000115659.5 NM_138661 PCDA9_MOUSE Pcdha9 Q91Y11 uc008epe.1 uc008epe.2 uc008epe.3 uc008epe.4 uc008epe.5 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein The protocadherins alpha are expressed from a single gene cluster similarly to immunoglobulin and T-cell receptors. The N- terminal region containing the 6 extracellular cadherin domains, unique to each protocadherin alpha, is encoded by one of the large exons found in tandem array within the gene cluster. The C-terminal region, identical to all protocadherins alpha, is encoded by 3 shared exons. molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epe.1 uc008epe.2 uc008epe.3 uc008epe.4 uc008epe.5 
ENSMUST00000115661.5 Pcdha4b ENSMUST00000115661.5 protocadherin alpha 4B (from RefSeq NM_001174154.2) Cnr1 ENSMUST00000115661.1 ENSMUST00000115661.2 ENSMUST00000115661.3 ENSMUST00000115661.4 NM_001174154 O88689 PCDA4_MOUSE Pcdha4 Q3UEX3 Q6PAM9 Q8K487 Q8K489 uc008eoy.1 uc008eoy.2 uc008eoy.3 uc008eoy.4 uc008eoy.5 Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (Probable). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523). Forms homodimers in trans (molecules expressed by two different cells) (PubMed:27161523). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins (PubMed:27161523). Interacts with FYN (PubMed:9655502). O88689-1; Q99LI8: Hgs; NbExp=2; IntAct=EBI-15880299, EBI-2119135; Cell membrane ; Single-pass type I membrane protein te=Detected in dendrites and synapses. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O88689-1; Sequence=Displayed; Name=2; IsoId=O88689-2; Sequence=VSP_019413, VSP_019415; Name=3; IsoId=O88689-3; Sequence=VSP_019414; Detected in brain throughout embryonic development. Detected in adult brain, in particular in cerebellum and forebrain. Cadherin 1 to cadherin 4 domains mediate homophilic trans- interaction, the interaction with an identical protocadherin expressed by a neighboring cell (PubMed:27161523). This is an head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin (PubMed:27161523). The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane (PubMed:27161523). Each cadherin domain binds three calcium ions (PubMed:27161523). The protocadherins alpha are expressed from a single gene cluster similarly to immunoglobulin and T-cell receptors. The N- terminal region containing the 6 extracellular cadherin domains, unique to each protocadherin alpha, is encoded by one of the large exons found in tandem array within the gene cluster. The C-terminal region, identical to all protocadherins alpha, is encoded by 3 shared exons. calcium ion binding protein binding endoplasmic reticulum plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane identical protein binding synapse metal ion binding uc008eoy.1 uc008eoy.2 uc008eoy.3 uc008eoy.4 uc008eoy.5 
ENSMUST00000115662.9 Pcdha2 ENSMUST00000115662.9 protocadherin alpha 2 (from RefSeq NM_198117.2) ENSMUST00000115662.1 ENSMUST00000115662.2 ENSMUST00000115662.3 ENSMUST00000115662.4 ENSMUST00000115662.5 ENSMUST00000115662.6 ENSMUST00000115662.7 ENSMUST00000115662.8 NM_198117 Pcdha2 Q91Y17 Q91Y17_MOUSE uc008eov.1 uc008eov.2 uc008eov.3 uc008eov.4 uc008eov.5 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding nucleus endoplasmic reticulum plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eov.1 uc008eov.2 uc008eov.3 uc008eov.4 uc008eov.5 
ENSMUST00000115663.10 Slc35a2 ENSMUST00000115663.10 solute carrier family 35 (UDP-galactose transporter), member A2, transcript variant 1 (from RefSeq NM_078484.3) A2AER4 A2AER4_MOUSE ENSMUST00000115663.1 ENSMUST00000115663.2 ENSMUST00000115663.3 ENSMUST00000115663.4 ENSMUST00000115663.5 ENSMUST00000115663.6 ENSMUST00000115663.7 ENSMUST00000115663.8 ENSMUST00000115663.9 NM_078484 Slc35a2 uc009snb.1 uc009snb.2 uc009snb.3 Golgi apparatus membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. Golgi membrane nucleus endoplasmic reticulum Golgi apparatus pyrimidine nucleotide-sugar transmembrane transporter activity membrane integral component of membrane pyrimidine nucleotide-sugar transmembrane transport uc009snb.1 uc009snb.2 uc009snb.3 
ENSMUST00000115675.9 Gripap1 ENSMUST00000115675.9 GRIP1 associated protein 1, transcript variant 8 (from RefSeq NM_001426311.1) A2AEW8 A2AEW8_MOUSE ENSMUST00000115675.1 ENSMUST00000115675.2 ENSMUST00000115675.3 ENSMUST00000115675.4 ENSMUST00000115675.5 ENSMUST00000115675.6 ENSMUST00000115675.7 ENSMUST00000115675.8 Gripap1 NM_001426311 uc012hel.1 uc012hel.2 uc012hel.3 uc012hel.4 nucleoplasm cytosol intracellular membrane-bounded organelle postsynaptic recycling endosome neurotransmitter receptor transport, endosome to postsynaptic membrane glutamatergic synapse extrinsic component of postsynaptic early endosome membrane regulation of modification of synaptic structure uc012hel.1 uc012hel.2 uc012hel.3 uc012hel.4 
ENSMUST00000115682.2 E230025N22Rik ENSMUST00000115682.2 Riken cDNA E230025N22 gene (from RefSeq NM_172831.2) E230025N22Rik ENSMUST00000115682.1 G5E8S3 G5E8S3_MOUSE NM_172831 uc008eoe.1 uc008eoe.2 molecular_function cellular_component biological_process uc008eoe.1 uc008eoe.2 
ENSMUST00000115685.10 Aifm3 ENSMUST00000115685.10 apoptosis-inducing factor, mitochondrion-associated 3, transcript variant 1 (from RefSeq NM_001291070.1) AIFM3_MOUSE Aifl ENSMUST00000115685.1 ENSMUST00000115685.2 ENSMUST00000115685.3 ENSMUST00000115685.4 ENSMUST00000115685.5 ENSMUST00000115685.6 ENSMUST00000115685.7 ENSMUST00000115685.8 ENSMUST00000115685.9 NM_001291070 Q0VBD6 Q3TY86 Q4VAA4 Q8BWV0 uc007ykw.1 uc007ykw.2 uc007ykw.3 Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential (By similarity). Mitochondrion. Note=Does not translocate to the nucleus upon induction of apoptosis. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TY86-1; Sequence=Displayed; Name=2; IsoId=Q3TY86-2; Sequence=VSP_021306; Name=3; IsoId=Q3TY86-3; Sequence=VSP_021304, VSP_021305; The Rieske domain induces apoptosis. [Isoform 3]: May be due to intron retention. Belongs to the FAD-dependent oxidoreductase family. mitochondrion mitochondrial inner membrane endoplasmic reticulum cytosol apoptotic process oxidoreductase activity metal ion binding flavin adenine dinucleotide binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding oxidation-reduction process execution phase of apoptosis uc007ykw.1 uc007ykw.2 uc007ykw.3 
ENSMUST00000115695.4 Magix ENSMUST00000115695.4 MAGI family member, X-linked, transcript variant 1 (from RefSeq NM_018832.2) ENSMUST00000115695.1 ENSMUST00000115695.2 ENSMUST00000115695.3 MAGIX_MOUSE NM_018832 Pdzx Q4KL35 Q9JIG3 uc009sly.1 uc009sly.2 uc009sly.3 molecular_function cellular_component biological_process uc009sly.1 uc009sly.2 uc009sly.3 
ENSMUST00000115716.9 Psd2 ENSMUST00000115716.9 pleckstrin and Sec7 domain containing 2, transcript variant 3 (from RefSeq NR_110349.1) ENSMUST00000115716.1 ENSMUST00000115716.2 ENSMUST00000115716.3 ENSMUST00000115716.4 ENSMUST00000115716.5 ENSMUST00000115716.6 ENSMUST00000115716.7 ENSMUST00000115716.8 Efa6c NR_110349 PSD2_MOUSE Q6NZP0 Q6P1I6 Q6PHQ7 Q8BHR9 Q9D3B8 uc008ena.1 uc008ena.2 uc008ena.3 uc008ena.4 uc008ena.5 uc008ena.6 Cell membrane ; Single-pass membrane protein Cell projection, ruffle membrane Cleavage furrow Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions. In cells undergoing cytokinesis, transiently found around the ingressing cleavage furrow. Not detected at the midbody ring/Flemming body. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P1I6-1; Sequence=Displayed; Name=2; IsoId=Q6P1I6-2; Sequence=VSP_033640; Name=3; IsoId=Q6P1I6-3; Sequence=VSP_033639; Belongs to the PSD family. ARF guanyl-nucleotide exchange factor activity phospholipid binding plasma membrane membrane integral component of membrane dendrite regulation of ARF protein signal transduction cleavage furrow ruffle membrane cell projection neuronal cell body postsynapse glutamatergic synapse uc008ena.1 uc008ena.2 uc008ena.3 uc008ena.4 uc008ena.5 uc008ena.6 
ENSMUST00000115726.9 Cacna1f ENSMUST00000115726.9 calcium channel, voltage-dependent, alpha 1F subunit (from RefSeq NM_019582.2) Cacna1f Cav1.4 ENSMUST00000115726.1 ENSMUST00000115726.2 ENSMUST00000115726.3 ENSMUST00000115726.4 ENSMUST00000115726.5 ENSMUST00000115726.6 ENSMUST00000115726.7 ENSMUST00000115726.8 NM_019582 Q7TNI3 Q7TNI3_MOUSE uc009slp.1 uc009slp.2 uc009slp.3 Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Membrane ; Multi- pass membrane protein Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. photoreceptor outer segment ion channel activity voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity voltage-gated calcium channel complex ion transport calcium ion transport visual perception high voltage-gated calcium channel activity membrane integral component of membrane regulation of ion transmembrane transport neuronal cell body T cell homeostasis perikaryon regulation of T cell receptor signaling pathway detection of light stimulus involved in visual perception transmembrane transport calcium ion transmembrane transport uc009slp.1 uc009slp.2 uc009slp.3 
ENSMUST00000115728.5 Sting1 ENSMUST00000115728.5 stimulator of interferon response cGAMP interactor 1, transcript variant 1 (from RefSeq NM_028261.1) A7YGY9 ENSMUST00000115728.1 ENSMUST00000115728.2 ENSMUST00000115728.3 ENSMUST00000115728.4 Eris Mita Mpys NM_028261 Q3TAV5 Q3TBT3 Q3TYP5 Q3TZY8 Q3UJW3 Q8C227 Q8C5Q3 Q8K393 Q9CZY7 STING_MOUSE Sting Sting1 Tmem173 uc008emt.1 uc008emt.2 uc008emt.3 uc008emt.4 uc008emt.5 Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:26229117, PubMed:26669264, PubMed:27324217, PubMed:28529930, PubMed:29973723). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:26229117, PubMed:26669264). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di- GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (PubMed:21947006, PubMed:23722158, PubMed:23258412, PubMed:23519410, PubMed:23910378). Upon binding of c-di-GMP or cGAMP, STING1 oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state (PubMed:25636800, PubMed:27324217, PubMed:29973723). In addition to promote the production of type I interferons, plays a direct role in autophagy (PubMed:30568238). Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (By similarity). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome (By similarity). The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (By similarity). Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy (PubMed:29056340). Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263). The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, whichs adopts an organized free- ligand conformation that resembles the STING1-bound conformation and pays low energy costs in changing into the active conformation (By similarity). May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons (By similarity). May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) (PubMed:18559423). Activated by anticancer drug 5,6- dimethylxanthenone 4-acetic acid (DMXAA) (PubMed:23910378, PubMed:26669264). Specifically inhibited by nitrofuran derivatives C- 178 and C-176, which covalently bind Cys-91 and prevent palmitoylation and subsequent activation od STING1 (PubMed:29973723). Homodimer; forms a homodimer in absence of cyclic nucleotide (c-di-GMP or cGAMP); 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization (PubMed:18559423). Homotetramer; in presence of cyclic nucleotide (c-di-GMP or cGAMP), forms tetramers and higher-order oligomers through side-by-side packing (By similarity). Interacts (when phosphorylated) with IRF3; following activation and phosphorylation on the pLxIS motif by TBK1, recruits IRF3 (By similarity). Interacts with RIGI, MAVS and SSR2 (By similarity). Interacts with RNF5 and TRIM56 (By similarity). Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta (By similarity). Interacts with IFIT1 and IFIT2 (By similarity). Interacts with TRIM29; this interaction induces STING1 ubiquitination and subsequent degradation (By similarity). Associates with the MHC-II complex (PubMed:18559423). Interacts with STEEP; the interaction is increased upon cGAMP binding and promotes STING1 translocation to COPII vesicles (By similarity). Interacts with SEC24A, SEC24B and SEC24C; promoting translocation to COPII vesicles (By similarity). Interacts (when ubiquitinated) with SQSTM1; leading to relocalization to autophagosomes (PubMed:29496741). Interacts with SURF4 (By similarity). Interacts with HNRNPA2B1 (PubMed:31320558). Interacts with ZDHHC1; ZDHHC1 constitutively interacts with STING1 and in presence of DNA viruses activates it by promoting its cGAMP-induced oligomerization and the recruitment of downstream signaling components (By similarity). Interacts with ZDHHC11; in presence of DNA viruses promotes the recruitment of IRF3 to STING1 (By similarity). Interacts with TOMM70 (By similarity). Interacts with IFI204 (PubMed:28529930). Q3TBT3; Q91VN6: Ddx41; NbExp=4; IntAct=EBI-3862093, EBI-2551902; Q3TBT3; Q9WUN2: Tbk1; NbExp=3; IntAct=EBI-3862093, EBI-764193; Endoplasmic reticulum membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi- pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein Mitochondrion outer membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=In response to double-stranded DNA stimulation, translocates from the endoplasmic reticulum through the endoplasmic reticulum-Golgi intermediate compartment and Golgi to post- Golgi vesicles, where the kinase TBK1 is recruited. Upon cGAMP-binding, translocates to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) in a process that is dependent on COPII vesicles; STING1-containing ERGIC serves as a membrane source for LC3 lipidation, which is a key step in autophagosome biogenesis. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TBT3-1; Sequence=Displayed; Name=2; IsoId=Q3TBT3-2; Sequence=VSP_022284; Name=3; IsoId=Q3TBT3-3; Sequence=VSP_022285; Present in spleen and thymus tissue. Also present in dendritic cells (at protein level). Expressed throughout the B-cell lineage prior to the plasma cell stage but occurs at highest levels in mature B-cells. Highly expressed in cells representing mature stages of B-cells but weakly expressed in pre-B cells, immature B-cells, and memory B-cell stages. Not detected in plasma cells. In absence of cGAMP, the transmembrane and cytoplasmic regions interact to form an integrated, domain-swapped dimeric assembly (By similarity). In absence of cyclic nucleotide (c-di-GMP or cGAMP), the protein is autoinhibited by an intramolecular interaction between the cyclic dinucleotide-binding domain (CBD) and the C-terminal tail (CTT) (By similarity). Following cGAMP-binding, the cyclic dinucleotide- binding domain (CBD) is closed, leading to a 180 degrees rotation of the CBD domain relative to the transmembrane domain. This rotation is coupled to a conformational change in a loop on the side of the CBD dimer, which leads to the formation of the STING1 tetramer and higher- order oligomers through side-by-side packing (By similarity). The N- terminal part of the CBD region was initially though to contain a fifth transmembrane region (TM5) but is part of the folded, soluble CBD (By similarity). The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of STING1 recruits IRF3. IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and other cytokines. The N-terminal domain interacts with glycerophospholipids and phospholipids. Phosphorylation by TBK1 leads to activation and production of IFN- beta (By similarity). Following cyclic nucleotide (c-di-GMP or cGAMP)- binding, activation and translocation from the endoplasmic reticulum, STING1 is phosphorylated by TBK1 at Ser-365 in the pLxIS motif (By similarity). The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines (PubMed:27637147). The phosphorylated pLxIS motif facilitates SENP2 recruitment during late phase of viral infection (PubMed:27637147). Phosphorylated on tyrosine residues upon MHC-II aggregation (PubMed:18559423). Dephosphorylation by PPP6C leads to inactivation and decreased production of IFN-beta (By similarity). Phosphorylation at Ser-357 is also required to activate IRF3 (PubMed:25636800). Ubiquitinated (PubMed:29496741). Ubiquitinated via 'Lys-63'-linked ubiquitin chains in response to double-stranded DNA treatment, leading to relocalization to autophagosomes and subsequent degradation; this process is dependent on SQSTM1 (PubMed:29496741). 'Lys-63'-linked ubiquitination mediated by TRIM56 at Lys-150 promotes homodimerization and recruitment of the antiviral kinase TBK1 and subsequent production of IFN-beta (By similarity). 'Lys-48'-linked polyubiquitination at Lys- 150 occurring after viral infection is mediated by RNF5 and leads to proteasomal degradation (By similarity). 'Lys-11'-linked polyubiquitination at Lys-150 by RNF26 leads to stabilize STING1: it protects STING1 from RNF5-mediated 'Lys-48'-linked polyubiquitination (By similarity). 'Lys-33'-linked and 'Lys-48'-linked deubiquitinated by USP20; leading to its stabilization and promotion of innate antiviral response (By similarity). 'Lys-48'-linked deubiquitinated by USP44; leading to its stabilization and promotion of innate antiviral response (By similarity). Deubiquitinated by USP13; leading to inhibition of innate antiviral response (By similarity). Sumoylated at Lys-337 by TRIM38 during the early phase of viral infection, promoting its stability by preventing its relocalization to autophagosomes and subsequent degradation (PubMed:27637147). Desumoylated by SENP2 during the late phase of viral infection (PubMed:27637147). Palmitoylation takes place in the Golgi apparatus and creates a platform for the recruitment of TBK1. Defects in innate immunity. Death within 7 days of herpes simplex virus 1 (HSV-1) infection. In addition, mice show a remarkable reduction in cytotoxic T-cell responses after plasmid DNA vaccination. Cells fail to induce type I interferon production in response to dsDNA and infection with herpes simplex virus 1 (HSV-1) and L.monocytogenes that deliver DNA to the host cytosol. Was named MPYS because the protein sequence begins by Met-Pro-Tyr-Ser residues. Belongs to the STING family. Sequence=AAH27757.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC37010.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAE42563.1; Type=Frameshift; Evidence=; autophagosome assembly nucleotide binding autophagosome membrane activation of innate immune response positive regulation of defense response to virus by host immune system process protein binding cytoplasm mitochondrion mitochondrial outer membrane endosome autophagosome peroxisome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane autophagy transcription factor binding regulation of gene expression membrane integral component of membrane positive regulation of macroautophagy protein kinase binding regulation of cellular metabolic process cytoplasmic vesicle ubiquitin protein ligase binding positive regulation of protein binding positive regulation of type I interferon production interferon-beta production endoplasmic reticulum-Golgi intermediate compartment membrane cyclic-di-GMP binding cellular response to interferon-beta cytoplasmic pattern recognition receptor signaling pathway in response to virus identical protein binding protein homodimerization activity innate immune response positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm regulation of inflammatory response positive regulation of sequence-specific DNA binding transcription factor activity protein oligomerization defense response to virus cyclic-GMP-AMP binding reticulophagy cellular response to exogenous dsRNA cellular response to organic cyclic compound integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane uc008emt.1 uc008emt.2 uc008emt.3 uc008emt.4 uc008emt.5 
ENSMUST00000115733.3 Gucy1a2 ENSMUST00000115733.3 guanylate cyclase 1, soluble, alpha 2 (from RefSeq NM_001033322.2) ENSMUST00000115733.1 ENSMUST00000115733.2 F8VQK3 F8VQK3_MOUSE Gucy1a2 NM_001033322 uc009obd.1 uc009obd.2 uc009obd.3 uc009obd.4 uc009obd.5 Cytoplasm Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding guanylate cyclase activity cGMP biosynthetic process cyclic nucleotide biosynthetic process positive regulation of nitric oxide mediated signal transduction lyase activity phosphorus-oxygen lyase activity heme binding intracellular signal transduction uc009obd.1 uc009obd.2 uc009obd.3 uc009obd.4 uc009obd.5 
ENSMUST00000115740.9 Foxp3 ENSMUST00000115740.9 forkhead box P3, transcript variant 1 (from RefSeq NM_001199347.1) ENSMUST00000115740.1 ENSMUST00000115740.2 ENSMUST00000115740.3 ENSMUST00000115740.4 ENSMUST00000115740.5 ENSMUST00000115740.6 ENSMUST00000115740.7 ENSMUST00000115740.8 FOXP3_MOUSE NM_001199347 Q99JB6 uc009slm.1 uc009slm.2 uc009slm.3 uc009slm.4 The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene result in the scurfy phenotype (sf). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:22813742). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (By similarity). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (By similarity). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (PubMed:19696312). Homodimer (PubMed:22813742). Dimerization is essential for its transcriptional regulator activity. Interacts with IKZF3 (By similarity). Interacts (via LXXLL motif) with isoform 4 of RORA (via AF-2 motif) (By similarity). Interacts with STUB1 and HSPA1A/B. Interacts with IKZF4, HDAC7 and KAT5. Interacts with RUNX1, RUNX2, RUNX3 and NFATC2. Interacts with RORC. Interacts with HDAC9 in the absence of T-cell stimulation (By similarity). Interacts with RELA, PPP1CA, PPP1CB, PPP1CG, HSPA8 and USP7 (By similarity). Q99JB6; Q03347: Runx1; NbExp=5; IntAct=EBI-10956246, EBI-3863873; Q99JB6; Q8C2S0: Usp44; NbExp=3; IntAct=EBI-10956246, EBI-26303241; Nucleus toplasm Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg) (By similarity). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells. High level of expression in thymus and spleen. By TGFB1 in T-cells. Down-regulated in regulatory T-cells (Treg) during inflammation. The fork-head DNA-binding domain is essential for its dimerization and interaction with NFATC2. Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions (PubMed:22312127). Acetylation is mediated by a coordinated action of KAT5 and EP300/p300 acetyltransferases: EP300/p300 is required to enhance KAT5 autoacetylation, promoting acetylation of FOXP3 by KAT5 (By similarity). Deacetylated by SIRT1 (PubMed:22312127). Polyubiquitinated, leading to its proteasomal degradation in regulatory T-cells (Treg) which is mediated by STUB1 in a HSPA1A/B- dependent manner. Deubiquitinated by USP7 and USP44 leading to increase in protein stability. Phosphorylation at Ser-418 regulates its transcriptional repressor activity and consequently, regulatory T-cells (Treg) suppressive function (By similarity). Phosphorylation by CDK2 negatively regulates its transcriptional activity and protein stability. Undergoes proteolytic cleavage in activated regulatory T-cells (Treg), and can be cleaved at either the N- or C-terminal site, or at both sites. Treg expressing the form cleaved at C-terminal site or both N- and C-terminal sites exhibit an increased induction of IL10 and an increased capacity to suppress proliferation of conventional T-cells in vitro. Treg expressing the form cleaved at only the C-terminal site are highly effective at preventing experimental colitis in an in vivo model of inflammatory bowel disease. Note=Defects in Foxp3 are the cause of the scurfy phenotype (sf). It results in a lethal disorder of immunoregulation, characterized by infections, diarrhea, anemia, thrombocytopenia, hypogonadism, gastrointestinal bleeding, lymphadenopathy and leukocytosis. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding B cell homeostasis cytokine production myeloid cell homeostasis CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment T cell mediated immunity tolerance induction tolerance induction to self antigen regulation of immunoglobulin production positive regulation of T cell tolerance induction regulation of T cell anergy positive regulation of T cell anergy negative regulation of chronic inflammatory response negative regulation of T cell cytokine production positive regulation of peripheral T cell tolerance induction nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter negative regulation of cell proliferation response to virus positive regulation of gene expression negative regulation of gene expression negative regulation of histone deacetylation negative regulation of NF-kappaB transcription factor activity negative regulation of interferon-gamma production negative regulation of interleukin-10 production negative regulation of interleukin-17 production negative regulation of interleukin-2 production negative regulation of interleukin-4 production negative regulation of interleukin-5 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of interleukin-4 production negative regulation of CREB transcription factor activity positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of transforming growth factor beta1 production positive regulation of immature T cell proliferation in thymus histone acetyltransferase binding positive regulation of histone acetylation negative regulation of histone acetylation negative regulation of cytokine biosynthetic process T cell activation negative regulation of T cell proliferation protein homodimerization activity histone deacetylase binding negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding negative regulation of interferon-gamma biosynthetic process negative regulation of interleukin-2 biosynthetic process positive regulation of regulatory T cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding negative regulation of isotype switching to IgE isotypes regulation of isotype switching to IgG isotypes negative regulation of lymphocyte proliferation negative regulation of cytokine secretion negative regulation of inflammatory response negative regulation of immune response T cell receptor signaling pathway NFAT protein binding negative regulation of T-helper 17 cell differentiation uc009slm.1 uc009slm.2 uc009slm.3 uc009slm.4 
ENSMUST00000115742.9 Ppp1r3f ENSMUST00000115742.9 protein phosphatase 1, regulatory subunit 3F, transcript variant 2 (from RefSeq NM_138605.4) B1AW09 B1AW10 DXImx48e ENSMUST00000115742.1 ENSMUST00000115742.2 ENSMUST00000115742.3 ENSMUST00000115742.4 ENSMUST00000115742.5 ENSMUST00000115742.6 ENSMUST00000115742.7 ENSMUST00000115742.8 NM_138605 PPR3F_MOUSE Q3UGL4 Q6PCL6 Q9JIG4 uc009slj.1 uc009slj.2 uc009slj.3 uc009slj.4 uc009slj.5 Glycogen-targeting subunit for protein phosphatase 1 (PP1). Membrane ; Single- pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JIG4-1; Sequence=Displayed; Name=2; IsoId=Q9JIG4-2; Sequence=VSP_021363; Highly expressed in brain (at protein level). Sequence=AAF66954.2; Type=Erroneous initiation; Evidence=; Sequence=AAH59275.1; Type=Erroneous initiation; Evidence=; Sequence=CAM14759.1; Type=Erroneous initiation; Evidence=; regulation of glycogen biosynthetic process membrane integral component of membrane protein phosphatase binding regulation of glycogen (starch) synthase activity glycogen binding uc009slj.1 uc009slj.2 uc009slj.3 uc009slj.4 uc009slj.5 
ENSMUST00000115747.3 Ttll2 ENSMUST00000115747.3 tubulin tyrosine ligase-like family, member 2, transcript variant 2 (from RefSeq NM_001414354.1) A4Q9E4 ENSMUST00000115747.1 ENSMUST00000115747.2 NM_001414354 TTLL2_MOUSE Ttll2 uc008ain.1 uc008ain.2 uc008ain.3 Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins (PubMed:17499049). Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity (By similarity). Probably involved in the side- chain initiation step of the polyglutamylation reaction rather than the elongation step (Probable). Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Highly expressed in brain, kidney, liver and testis (PubMed:17499049). Expressed in heart, lung, muscle and spleen (PubMed:17499049). Arg-175 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate- chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation. Belongs to the tubulin--tyrosine ligase family. nucleotide binding molecular_function ATP binding cellular_component cellular protein modification process biological_process ligase activity uc008ain.1 uc008ain.2 uc008ain.3 
ENSMUST00000115752.8 Ccnb3 ENSMUST00000115752.8 cyclin B3 (from RefSeq NM_183015.4) A2AEP2 A2AEP2_MOUSE Ccnb3 ENSMUST00000115752.1 ENSMUST00000115752.2 ENSMUST00000115752.3 ENSMUST00000115752.4 ENSMUST00000115752.5 ENSMUST00000115752.6 ENSMUST00000115752.7 NM_183015 uc009slb.1 uc009slb.2 Belongs to the cyclin family. regulation of cyclin-dependent protein serine/threonine kinase activity nucleus regulation of G2/M transition of mitotic cell cycle protein kinase binding uc009slb.1 uc009slb.2 
ENSMUST00000115777.10 Ube2v2 ENSMUST00000115777.10 ubiquitin-conjugating enzyme E2 variant 2, transcript variant 1 (from RefSeq NM_023585.4) A6X924 ENSMUST00000115777.1 ENSMUST00000115777.2 ENSMUST00000115777.3 ENSMUST00000115777.4 ENSMUST00000115777.5 ENSMUST00000115777.6 ENSMUST00000115777.7 ENSMUST00000115777.8 ENSMUST00000115777.9 Mms2 NM_023585 Q8BGH6 Q8CE99 Q8K2V7 Q9CYD7 Q9D2M8 Q9ERI8 UB2V2_MOUSE Uev2 uc007yhp.1 uc007yhp.2 uc007yhp.3 uc007yhp.4 Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Heterodimer with UBE2N. Binds CHFR (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D2M8-1; Sequence=Displayed; Name=2; IsoId=Q9D2M8-2; Sequence=VSP_011529; Belongs to the ubiquitin-conjugating enzyme family. Sequence=AAH29742.1; Type=Erroneous initiation; Evidence=; DNA double-strand break processing protein binding nucleus nucleoplasm postreplication repair positive regulation of neuron projection development UBC13-MMS2 complex positive regulation of proteasomal ubiquitin-dependent protein catabolic process error-free postreplication DNA repair negative regulation of neuron apoptotic process positive regulation of DNA repair positive regulation of synapse assembly ubiquitin conjugating enzyme activity protein K63-linked ubiquitination uc007yhp.1 uc007yhp.2 uc007yhp.3 uc007yhp.4 
ENSMUST00000115791.10 Synj2 ENSMUST00000115791.10 synaptojanin 2, transcript variant 1 (from RefSeq NM_001113353.2) ENSMUST00000115791.1 ENSMUST00000115791.2 ENSMUST00000115791.3 ENSMUST00000115791.4 ENSMUST00000115791.5 ENSMUST00000115791.6 ENSMUST00000115791.7 ENSMUST00000115791.8 ENSMUST00000115791.9 F8WHD8 F8WHD8_MOUSE NM_001113353 Synj2 uc008afk.1 uc008afk.2 uc008afk.3 uc008afk.4 uc008afk.5 Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol 4-phosphate) + phosphate; Xref=Rhea:RHEA:22764, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456; EC=3.1.3.36; Evidence=; Belongs to the synaptojanin family. In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. nucleic acid binding RNA binding hydrolase activity phosphatidylinositol phosphate 5-phosphatase activity phosphoric ester hydrolase activity phosphatidylinositol dephosphorylation uc008afk.1 uc008afk.2 uc008afk.3 uc008afk.4 uc008afk.5 
ENSMUST00000115800.2 Nox3 ENSMUST00000115800.2 NADPH oxidase 3 (from RefSeq NM_198958.2) ENSMUST00000115800.1 NM_198958 NOX3_MOUSE Q672J9 Q6Y4Q8 uc008aev.1 uc008aev.2 uc008aev.3 This gene encodes a member of the NOX family of NADPH oxidases. These enzymes catalyze the transfer of electrons from NADPH to molecular oxygen to produce superoxide and other reactive oxygen species (ROS). The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia, which are crystalline structures of the inner ear involved in the perception of gravity and linear acceleration. In mouse mutations of this gene lead to the absence of otoconia and vestibular dysfunction. [provided by RefSeq, Jun 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC106862.2, AY182377.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849384, SAMN00849385 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor, upon formation of a complex with CYBA/p22phox (PubMed:15326186, PubMed:17140397). Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (PubMed:15014044). Reaction=NADPH + 2 O2 = H(+) + NADP(+) + 2 superoxide; Xref=Rhea:RHEA:63180, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18421, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Activated by the ototoxic drug cisplatin. Activated by NOXO1. Cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. Inhibited by diphenyleneiodonium chloride. Forms a heterodimer with CYBA/p22phox which is essential for its activity and cell membrane localization. Cell membrane ; Multi-pass membrane protein Specifically expressed in inner ear by the spiral glanglion neurons, the vestibular system and the sensory epithelial cell layer of the saccule. Weakly expressed in skull and brain. Expressed in fetal kidney. N-glycosylated in a CYBA/p22phox-dependent manner. Mice display balance defects, a tilted position of the head and abnormal performances in motor coordination tests. This is associated with the absence of otoconia in both the utricle and saccule of the inner ear. Sequence=AAI06863.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAO65981.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; temperature homeostasis protein binding cytoplasm plasma membrane defense response detection of gravity response to gravity membrane integral component of membrane superoxide-generating NADPH oxidase activity oxidoreductase activity superoxide anion generation NADPH oxidase complex otolith development oxidation-reduction process uc008aev.1 uc008aev.2 uc008aev.3 
ENSMUST00000115804.9 Pdxdc1 ENSMUST00000115804.9 pyridoxal-dependent decarboxylase domain containing 1, transcript variant 3 (from RefSeq NM_001039533.2) ENSMUST00000115804.1 ENSMUST00000115804.2 ENSMUST00000115804.3 ENSMUST00000115804.4 ENSMUST00000115804.5 ENSMUST00000115804.6 ENSMUST00000115804.7 ENSMUST00000115804.8 NM_001039533 PDXD1_MOUSE Q3TCL3 Q3TN13 Q8BMK9 Q8BW02 Q8BW51 Q8BZZ4 Q99K01 Q9DC25 uc007ygl.1 uc007ygl.2 uc007ygl.3 uc007ygl.4 Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q99K01-1; Sequence=Displayed; Name=2; IsoId=Q99K01-2; Sequence=VSP_027346; Name=3; IsoId=Q99K01-3; Sequence=VSP_027345; Name=4; IsoId=Q99K01-4; Sequence=VSP_027344; Name=5; IsoId=Q99K01-5; Sequence=VSP_029421, VSP_029422; Belongs to the group II decarboxylase family. Sequence=BAC35991.1; Type=Erroneous initiation; Evidence=; ameboidal-type cell migration catalytic activity endoplasmic reticulum Golgi apparatus sphingolipid metabolic process sphinganine-1-phosphate aldolase activity lyase activity carboxy-lyase activity carboxylic acid metabolic process sphingolipid catabolic process pyridoxal phosphate binding intracellular membrane-bounded organelle uc007ygl.1 uc007ygl.2 uc007ygl.3 uc007ygl.4 
ENSMUST00000115808.4 Ammecr1l ENSMUST00000115808.4 AMME chromosomal region gene 1-like, transcript variant 2 (from RefSeq NM_153515.4) AMERL_MOUSE ENSMUST00000115808.1 ENSMUST00000115808.2 ENSMUST00000115808.3 NM_153515 Q8JZZ6 uc008eig.1 uc008eig.2 uc008eig.3 uc008eig.4 molecular_function cellular_component biological_process uc008eig.1 uc008eig.2 uc008eig.3 uc008eig.4 
ENSMUST00000115812.10 Pik3c3 ENSMUST00000115812.10 phosphatidylinositol 3-kinase catalytic subunit type 3, transcript variant 1 (from RefSeq NM_181414.6) ENSMUST00000115812.1 ENSMUST00000115812.2 ENSMUST00000115812.3 ENSMUST00000115812.4 ENSMUST00000115812.5 ENSMUST00000115812.6 ENSMUST00000115812.7 ENSMUST00000115812.8 ENSMUST00000115812.9 NM_181414 PK3C3_MOUSE Pik3c3 Q6PF93 Q8R3S8 Vps34 uc008ehw.1 uc008ehw.2 uc008ehw.3 Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+); Xref=Rhea:RHEA:12709, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088, ChEBI:CHEBI:456216; EC=2.7.1.137; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12710; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex the core of which is composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 associating with additional regulatory/auxilliary subunits to form alternative complex forms. Alternative complex forms containing a forth regulatory subunit in a mutually exclusive manner are: the PI3K complex I (PI3KC3-C1) containing ATG14, and the PI3K complex II (PI3KC3-C2) containing UVRAG. PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex (By similarity). Both, PI3KC3-C1 and PI3KC3-C2, can associate with further regulatory subunits such as RUBCN, SH3GLB1/Bif-1 and AMBRA1 (PubMed:17589504). PI3KC3-C1 probably associates with PIK3CB (PubMed:21059846). Interacts with RAB7A in the presence of PIK3R4 (By similarity). Interacts with AMBRA1 (PubMed:17589504). Interacts with BECN1P1/BECN2 (By similarity). Interacts with SLAMF1 (PubMed:22493499). May be a component of a complex composed of RAB5A (in GDP-bound form), DYN2 and PIK3C3 (By similarity). Interacts with NCKAP1L (By similarity). Interacts with ATG14; this interaction is increased in the absence of TMEM39A (By similarity). Interacts with STEEP1; the interaction is STING1-dependent and required for trafficking of STING1 from the endoplasmic reticulum (By similarity). Interacts with YWHAG (By similarity). Interacts with ARMC3 (PubMed:34428398). Q6PF93; O88597: Becn1; NbExp=6; IntAct=EBI-6678149, EBI-643716; Q6PF93; P23242: Gja1; NbExp=4; IntAct=EBI-6678149, EBI-298630; Midbody Late endosome Cytoplasmic vesicle, autophagosome Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (PubMed:24089209). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PF93-1; Sequence=Displayed; Name=2; IsoId=Q6PF93-2; Sequence=VSP_016459, VSP_016460; Ubiquitinated via 'Lys-29'- and 'Lys-48'-linked ubiquitination by UBE3C, promoting its degradation. Deubiquitination by ZRANB1/TRABID promotes its stabilization, leading to autophagosome maturation. Belongs to the PI3/PI4-kinase family. autophagosome assembly nucleotide binding pre-autophagosomal structure protein kinase activity protein binding ATP binding cytoplasm endosome late endosome autophagosome peroxisome cytosol protein phosphorylation protein lipidation endocytosis autophagy endosome organization cell cycle cellular response to starvation membrane macroautophagy kinase activity 1-phosphatidylinositol-3-kinase activity phosphorylation protein processing transferase activity pexophagy midbody cytoplasmic vesicle regulation of cytokinesis phosphatidylinositol 3-kinase complex, class III, type I phosphatidylinositol 3-kinase complex, class III, type II protein localization to pre-autophagosomal structure phosphatidylinositol 3-kinase activity phosphatidylinositol 3-kinase complex, class III phosphatidylinositol-3-phosphate biosynthetic process cellular response to glucose starvation response to leucine autolysosome early endosome to late endosome transport phagocytic vesicle phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling regulation of protein secretion cell division uc008ehw.1 uc008ehw.2 uc008ehw.3 
ENSMUST00000115817.3 Tpgs2 ENSMUST00000115817.3 tubulin polyglutamylase complex subunit 2, transcript variant 2 (from RefSeq NM_001142697.1) 5730494M16Rik E9QLP0 E9QLP0_MOUSE ENSMUST00000115817.1 ENSMUST00000115817.2 NM_001142697 Tpgs2 uc008ehf.1 uc008ehf.2 uc008ehf.3 uc008ehf.4 uc008ehf.5 protein polyglutamylation uc008ehf.1 uc008ehf.2 uc008ehf.3 uc008ehf.4 uc008ehf.5 
ENSMUST00000115832.4 Dtna ENSMUST00000115832.4 dystrobrevin alpha, transcript variant 5 (from RefSeq NM_207650.4) Dtna ENSMUST00000115832.1 ENSMUST00000115832.2 ENSMUST00000115832.3 NM_207650 Q8CFR5 Q8CFR5_MOUSE uc008efy.1 uc008efy.2 uc008efy.3 uc008efy.4 Cytoplasm Belongs to the dystrophin family. Dystrobrevin subfamily. cytoplasm zinc ion binding PDZ domain binding axon extrinsic component of cytoplasmic side of plasma membrane macromolecular complex sarcolemma cell projection metal ion binding uc008efy.1 uc008efy.2 uc008efy.3 uc008efy.4 
ENSMUST00000115844.3 Glyr1 ENSMUST00000115844.3 glyoxylate reductase 1 homolog (Arabidopsis), transcript variant 4 (from RefSeq NM_001359748.1) D3YYT1 D3YYT1_MOUSE ENSMUST00000115844.1 ENSMUST00000115844.2 Glyr1 NM_001359748 uc007ybl.1 uc007ybl.2 uc007ybl.3 Chromosome Belongs to the HIBADH-related family. NP60 subfamily. nucleosome DNA binding chromatin binding nucleoplasm Golgi apparatus cytosol oxidoreductase activity nuclear speck nucleosome binding methylated histone binding positive regulation of histone acetylation histone binding positive regulation of transcription from RNA polymerase II promoter NADP binding NAD binding oxidation-reduction process uc007ybl.1 uc007ybl.2 uc007ybl.3 
ENSMUST00000115854.4 Dnaja3 ENSMUST00000115854.4 DnaJ heat shock protein family (Hsp40) member A3, transcript variant 2 (from RefSeq NM_001135112.1) DNJA3_MOUSE ENSMUST00000115854.1 ENSMUST00000115854.2 ENSMUST00000115854.3 NM_001135112 Q8BSM0 Q99L09 Q99M87 Q99P71 Q99P76 Q9CT11 Q9DBJ7 Q9DC44 Tid1 uc007yad.1 uc007yad.2 uc007yad.3 uc007yad.4 uc007yad.5 Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity (By similarity). Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain). Mitochondrion matrix Cytoplasm, cytosol Postsynaptic cell membrane ; Peripheral membrane protein Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Tid-1L, TID1L; IsoId=Q99M87-1; Sequence=Displayed; Name=2; Synonyms=Tid-1S, TID1S; IsoId=Q99M87-2; Sequence=VSP_007427, VSP_007428; Name=3; IsoId=Q99M87-3; Sequence=VSP_007440; Modulation of apoptosis, i.e. proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domain-dependent (By similarity). Tyrosine phosphorylated. negative regulation of transcription from RNA polymerase II promoter interferon-gamma receptor binding protein binding ATP binding nucleus cytoplasm mitochondrion mitochondrial matrix cytosol actin filament plasma membrane mitochondrial DNA replication protein folding negative regulation of protein kinase activity apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process activation-induced cell death of T cells mitochondrion organization small GTPase mediated signal transduction neuromuscular junction development cell aging transcription factor binding negative regulation of cell proliferation response to heat membrane extrinsic component of plasma membrane protein kinase binding cell junction Hsp70 protein binding GTPase regulator activity receptor tyrosine kinase binding heat shock protein binding positive regulation of protein ubiquitination neuromuscular junction negative regulation of NF-kappaB transcription factor activity T cell differentiation in thymus response to interferon-gamma positive regulation of T cell proliferation mitochondrial nucleoid positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of programmed cell death negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of cysteine-type endopeptidase activity involved in apoptotic process intracellular membrane-bounded organelle macromolecular complex binding synapse postsynaptic membrane metal ion binding protein stabilization NF-kappaB binding unfolded protein binding negative regulation of interferon-gamma-mediated signaling pathway skeletal muscle acetylcholine-gated channel clustering uc007yad.1 uc007yad.2 uc007yad.3 uc007yad.4 uc007yad.5 
ENSMUST00000115861.9 Rbbp8 ENSMUST00000115861.9 retinoblastoma binding protein 8, endonuclease, transcript variant 2 (from RefSeq NM_001252495.1) CTIP_MOUSE Ctip ENSMUST00000115861.1 ENSMUST00000115861.2 ENSMUST00000115861.3 ENSMUST00000115861.4 ENSMUST00000115861.5 ENSMUST00000115861.6 ENSMUST00000115861.7 ENSMUST00000115861.8 NM_001252495 Q80YR6 uc008ebl.1 uc008ebl.2 Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (By similarity). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (By similarity). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (By similarity). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (By similarity). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (By similarity). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (PubMed:21131978, PubMed:21131982). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (By similarity). Homotetramer; formed by antiparallel association of helical extensions protruding from the N-termini of two parallel coiled-coil dimers (By similarity). Forms a dumbbell-shaped particle in which polar globular domains are held about 30 nm apart by a central rod (By similarity). Homotetramerization is required for DNA-end resection and repair (By similarity). Interacts (via the PXDLS motif) with CTBP1; the interaction is disrupted via binding of the adenovirus E1A to CTBP1. Component of the BRCA1-RBBP8 complex. Interacts (the Ser-326 phosphorylated form) with BRCA1 (via the C-terminal BRCT domains): the interaction occurs in the G2 phase, ubiquitinates RBBP8 and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Interacts with RB1. Interacts with the MRN complex. Interacts directly with MRE11; the interaction is required for efficient homologous recombination (HR) and regulation of the MRN complex. Interacts directly with RAD50. Interacts directly with NBN. Interacts with LMO4 (via the LIM zinc-binding 1 domain) (PubMed:23353824). Interacts with SIAH1. Interacts with RNF138. Interacts with EXD2. Interacts with CUL3 and KLHL15; this interaction leads to RBBP8 proteasomal degradation. Directly interacts with PIN1; this interaction depends upon RBBP8 phosphorylation, predominantly at Thr-315. Interacts with FZR1; this interaction leads to APC/C-mediated RBBP8 proteasomal degradation. Interacts with AUNIP; leading to recruit RBBP8 to sites of DNA damage. Interacts with SAMHD1 (By similarity). Interacts with HDGFL2 (By similarity). Nucleus Chromosome Note=Associates with sites of DNA damage in S/G2 phase. Ubiquitinated RBBP8 binds to chromatin following DNA damage. The damage-recruitment motif is required for DNA binding and translocation to sites of DNA damage. The PXDLS motif binds to a cleft in CtBP proteins. Hyperphosphorylation upon ionizing radiation results in dissociation from BRCA1. Phosphorylation at Thr-843 by CDK1 is essential for the recruitment to DNA and the DNA repair function. Phosphorylated at Ser-326 as cells enter G2 phase. This phosphorylation is required for binding BRCA1 and for the G2/M DNA damage transition checkpoint control (By similarity). Phosphorylation at Thr-315 is required for PIN1-binding, while phosphorylation at Ser-276 serves as a PIN1 isomerization site. Phosphorylation at Thr-315 is cell-cycle dependent. It steadily increases during S phase, peaks at late S/G2 phase, and drops at G1 (By similarity). Phosphorylation is not required for tetramerization (By similarity). Binds to DNA more strongly when dephosphorylated (By similarity). Ubiquitinated. Ubiquitination at multiple sites by BRCA1 (via its N-terminal RING domain) does not lead to its proteasomal degradation but instead the ubiquitinated RBBP8 binds to chromatin following DNA damage and may play a role in G2/M checkpoint control. Ubiquitinated by RNF138 at its N-terminus. Ubiquitinated through 'Lys-48' by the E3 CUL3-KLHL15 complex; this modification leads to proteasomal degradation. Ubiquitinated by the E3 FZR1/APC/C complex; this modification leads to proteasomal degradation. Binds one Zn(2+) atom per dimer. Zn(2+)-binding is not required for homotetramerization. Belongs to the COM1/SAE2/CtIP family. Upon DNA damage, was shown to interact with SIRT6 resulting in its deacetylation. However, this study was later retracted. single-stranded DNA endodeoxyribonuclease activity G1/S transition of mitotic cell cycle Y-form DNA binding double-strand/single-strand DNA junction binding double-strand break repair via homologous recombination RNA polymerase II repressing transcription factor binding blastocyst hatching DNA binding damaged DNA binding double-stranded DNA binding single-stranded DNA binding transcription corepressor activity nuclease activity endonuclease activity nucleus nucleoplasm chromosome DNA repair nucleotide-excision repair cellular response to DNA damage stimulus cell cycle DNA double-strand break processing involved in repair via single-strand annealing hydrolase activity transcriptional repressor complex response to estradiol site of double-strand break identical protein binding intracellular membrane-bounded organelle cell division meiotic cell cycle flap-structured DNA binding nucleic acid phosphodiester bond hydrolysis negative regulation of nucleic acid-templated transcription uc008ebl.1 uc008ebl.2 
ENSMUST00000115869.4 Mpp7 ENSMUST00000115869.4 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7), transcript variant 3 (from RefSeq NM_001360860.1) ENSMUST00000115869.1 ENSMUST00000115869.2 ENSMUST00000115869.3 G5E8S8 G5E8S8_MOUSE Mpp7 NM_001360860 uc008dzs.1 uc008dzs.2 uc008dzs.3 uc008dzs.4 Cell junction, adherens junction Belongs to the MAGUK family. nucleoplasm adherens junction bicellular tight junction protein domain specific binding cell junction positive regulation of protein complex assembly protein heterodimerization activity binding, bridging bicellular tight junction assembly protein localization to adherens junction MPP7-DLG1-LIN7 complex uc008dzs.1 uc008dzs.2 uc008dzs.3 uc008dzs.4 
ENSMUST00000115891.2 Zfy2 ENSMUST00000115891.2 zinc finger protein 2, Y-linked (from RefSeq NM_009571.2) ENSMUST00000115891.1 NM_009571 P20662 Q3V0D8 ZFY2_MOUSE Zfy-2 uc009uzp.1 uc009uzp.2 Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity). Nucleus. The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13. Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated spermatogenesis spermatid development dosage compensation by inactivation of X chromosome metal ion binding meiotic recombination checkpoint uc009uzp.1 uc009uzp.2 
ENSMUST00000115894.3 Uba1y ENSMUST00000115894.3 Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (By similarity). The Y chromosome form could be involved in the survival and proliferation of differentiating spermatogonia. (from UniProt P31254) AF150963 ENSMUST00000115894.1 ENSMUST00000115894.2 P31254 Q60639 Q8CDH7 Q9QYS4 Q9QZX2 Sby UBA1Y_MOUSE Ube1ay Ube1y Ube1y1 uc009uyx.1 uc009uyx.2 Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (By similarity). The Y chromosome form could be involved in the survival and proliferation of differentiating spermatogonia. Reaction=ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]- L-cysteine.; EC=6.2.1.45; Evidence=; Protein modification; protein ubiquitination. Monomer. Expressed in testis in A spermatogonia and spermatids but not (or at very low levels) in pachytene spermatocytes. Also expressed in Y-bearing ovaries and at very low levels in adrenal gland. In testis, expression detected at 12.5 days post coitum (dpc) and peaking at 14.5 dpc, with expression dropping to low levels at the day of birth. After birth, levels increase 4-fold to a peak at 10 days post partum (dpp) and fall again thereafter. There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site. Belongs to the ubiquitin-activating E1 family. nucleotide binding ubiquitin activating enzyme activity ATP binding nucleus cytoplasm cellular protein modification process ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus spermatogenesis small protein activating enzyme activity protein ubiquitination ligase activity protein modification by small protein conjugation uc009uyx.1 uc009uyx.2 
ENSMUST00000115924.3 ENSMUSG00000079808 ENSMUST00000115924.3 sp110 nuclear body protein-like, transcript variant 2 (from RefSeq NM_001378740.1) ENSMUST00000115924.1 ENSMUST00000115924.2 NM_001378740 uc008idk.1 uc008idk.2 uc008idk.3 uc008idk.1 uc008idk.2 uc008idk.3 
ENSMUST00000115928.3 ENSMUSG00000094799 ENSMUST00000115928.3 ENSMUSG00000094799 (from geneSymbol) ENSMUST00000115928.1 ENSMUST00000115928.2 uc289spb.1 uc289spb.2 uc289spb.1 uc289spb.2 
ENSMUST00000115931.3 ENSMUSG00000079794 ENSMUST00000115931.3 ENSMUSG00000079794 (from geneSymbol) ENSMUST00000115931.1 ENSMUST00000115931.2 uc289spa.1 uc289spa.2 uc289spa.1 uc289spa.2 
ENSMUST00000115979.9 Esrp2 ENSMUST00000115979.9 epithelial splicing regulatory protein 2 (from RefSeq NM_176838.2) ENSMUST00000115979.1 ENSMUST00000115979.2 ENSMUST00000115979.3 ENSMUST00000115979.4 ENSMUST00000115979.5 ENSMUST00000115979.6 ENSMUST00000115979.7 ENSMUST00000115979.8 ESRP2_MOUSE NM_176838 Q8CEK2 Q8K0G8 Rbm35b uc009nff.1 uc009nff.2 uc009nff.3 mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Nucleus Epithelial cell-specific. Belongs to the ESRP family. alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding nucleus nucleoplasm mRNA processing RNA splicing regulation of RNA splicing positive regulation of epithelial cell proliferation epithelial tube branching involved in lung morphogenesis branching involved in salivary gland morphogenesis uc009nff.1 uc009nff.2 uc009nff.3 
ENSMUST00000115991.4 Or1e1b-ps1 ENSMUST00000115991.4 Or1e1b-ps1 (from geneSymbol) ENSMUST00000115991.1 ENSMUST00000115991.2 ENSMUST00000115991.3 uc288aap.1 uc288aap.2 uc288aap.1 uc288aap.2 
ENSMUST00000115995.4 Fads3 ENSMUST00000115995.4 fatty acid desaturase 3 (from RefSeq NM_021890.3) ENSMUST00000115995.1 ENSMUST00000115995.2 ENSMUST00000115995.3 FADS3_MOUSE Fads3 MNCb-0629 NM_021890 Q7TND7 Q8C4Y5 Q8CDZ4 Q9JJE7 uc008goz.1 uc008goz.2 uc008goz.3 Mammals have different sphingoid bases that differ in their length and/or pattern of desaturation and hydroxyl groups. The predominant sphingoid base that comprises mammalian ceramides is sphing-4-enine (sphingosine or SPH) which has a trans (E) desaturation at carbon 4. FADS3 is a desaturase that introduces a cis (Z) double bond between carbon 14 and carbon 15 of the sphingoid base (also known as long chain base, LCB), producing LCBs such as sphinga-4,14-dienine (SPD, d18:2(4E,14Z)) from SPH. Prefers SPH-containing ceramides (N- acylsphing-4-enines) as substrates. Capable of metabolizing also the SPH in its free form. SPD ceramides occur widely in mammalian tissues and cells. Due to their unusual structure containing a cis double bond, SPD ceramides may have an opposite, negative role in lipid microdomain formation relative to conventional ceramides. Could be involved in the detoxification of 1-deoxy sphingolipids, by desaturating the cytotoxic 1-deoxysphinganine (1-deoxySA, m18:0), produced under pathological conditions, to 1-deoxysphingenine (1-deoxysphingosine, 1-deoxySO, m18:1). Although prefers SPH-containing ceramides (N-acylsphing-4- enines) as substrates, it also exhibits activity toward dihydrosphingosine-containing CERs (N-acylsphinganines) and produces 14Z-SPH-containing sphingolipids. Its desaturase mechanism involves an electron transfer facilitated by cytochrome b5 (By similarity). FADS3 also acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)- octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 13 to generate (11E,13Z)-octadecadienoate (also known as conjugated linoleic acid 11E,13Z-CLA) (By similarity). Reaction=an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:63928, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:52639, ChEBI:CHEBI:139573; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63929; Evidence=; Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z- dienine; Xref=Rhea:RHEA:63940, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:63867, ChEBI:CHEBI:149631; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63941; Evidence=; Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphing-4-enine = 2 Fe(III)-[cytochrome b5] + 2 H2O + sphinga-4E,14Z-dienine; Xref=Rhea:RHEA:76483, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57756, ChEBI:CHEBI:83568; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76484; Evidence=; Reaction=(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:46056, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:74296, ChEBI:CHEBI:85650; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46057; Evidence=; Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + N-acyl-1-deoxysphinganine + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-1-deoxysphing-14Z- enine; Xref=Rhea:RHEA:76487, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:67111, ChEBI:CHEBI:195246; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76488; Evidence=; Reaction=an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acylsphing-14Z-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O; Xref=Rhea:RHEA:76563, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:31488, ChEBI:CHEBI:195278; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76564; Evidence=; Lipid metabolism; polyunsaturated fatty acid biosynthesis. Lipid metabolism; sphingolipid metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Highly expressed in liver and kidney (at protein level). The protein sequence includes a number of characteristic features of microsomal fatty acid desaturases including the three histidine boxes (these domains may contain the active site and/or be involved in metal ion binding), and the N-terminal cytochrome b5 domain containing the heme-binding motif, HPGG, similar to that of other fatty acid desaturases. Two potential isoforms are detected in various tissues. A 75 kDa isoform is expressed in lung. A 37 kDa isoform is expressed in lung, liver and kidney. Belongs to the fatty acid desaturase type 1 family. cellular_component endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process biological_process membrane integral component of membrane oxidoreductase activity oxidation-reduction process uc008goz.1 uc008goz.2 uc008goz.3 
ENSMUST00000116094.5 Rnf186 ENSMUST00000116094.5 ring finger protein 186 (from RefSeq NM_025786.4) ENSMUST00000116094.1 ENSMUST00000116094.2 ENSMUST00000116094.3 ENSMUST00000116094.4 NM_025786 Q78R58 Q9D241 RN186_MOUSE Rnf186 uc008vlo.1 uc008vlo.2 uc008vlo.3 uc008vlo.4 E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis. Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens (PubMed:34623328). Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR. Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2. Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction (PubMed:33280498). Controls nutrient sensing by ubiquitinating Sestrin-2/SESN2, which is an intracellular sensor of cytosolic leucine and inhibitor of mTORC1 activity. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with BNIP1. Endoplasmic reticulum membrane ; Multi-pass membrane protein The RING-type domain is required for ubiquitination. Polyubiquitinated. 'Lys-29'-linked autoubiquitination leads to proteasomal degradation. Mutant deletion mice demonstrate an increased bacterial burden in the mesenteric lymph nodes and spleen compared with WT mice (PubMed:34623328). They have also a more severe phenotype in the dextran sodium sulfate-induced colitis model, which is due to a defect in autophagy in colon epithelial cells (PubMed:33280498). Sequence=BAB32149.2; Type=Erroneous initiation; Evidence=; ubiquitin-protein transferase activity endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane protein ubiquitination transferase activity protein K29-linked ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding protein autoubiquitination ubiquitin protein ligase activity intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress protein K63-linked ubiquitination protein localization to mitochondrion uc008vlo.1 uc008vlo.2 uc008vlo.3 uc008vlo.4 
ENSMUST00000116172.2 Gm11175 ENSMUST00000116172.2 Gm11175 (from geneSymbol) ENSMUST00000116172.1 uc292ark.1 uc292ark.2 uc292ark.1 uc292ark.2 
ENSMUST00000116186.4 Spin2-ps2 ENSMUST00000116186.4 Spin2-ps2 (from geneSymbol) ENSMUST00000116186.1 ENSMUST00000116186.2 ENSMUST00000116186.3 uc292pal.1 uc292pal.2 uc292pal.3 uc292pal.1 uc292pal.2 uc292pal.3 
ENSMUST00000116231.4 Eef1akmt3 ENSMUST00000116231.4 EEF1A lysine methyltransferase 3 (from RefSeq NM_001205036.1) D3YWP0 EFMT3_MOUSE ENSMUST00000116231.1 ENSMUST00000116231.2 ENSMUST00000116231.3 Eef1akmt3 Fam119b Mettl21b NM_001205036 mCG_5197 uc029rjq.1 uc029rjq.2 uc029rjq.3 Protein-lysine methyltransferase that selectively mono-, di- and trimethylates 'Lys-165' of the translation elongation factors EEF1A1 and EEF1A2 in an aminoacyl-tRNA and GTP-dependent manner (By similarity). EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation (PubMed:28108655). Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54193; Evidence=; Reaction=L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:51736, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13053, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51737; Evidence=; Reaction=N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54196, Rhea:RHEA-COMP:13053, Rhea:RHEA-COMP:13827, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54197; Evidence=; Reaction=N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54200, Rhea:RHEA-COMP:13826, Rhea:RHEA- COMP:13827, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961, ChEBI:CHEBI:61976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54201; Evidence=; Interacts with members of the heat shock protein 70 and 90 families and of the TCP-1 chaperonin family, as well as with HSPD1, STIP1 and tubulin; at least some of these proteins may be methylation substrates. Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Belongs to the methyltransferase superfamily. METTL21 family. cytoplasm centrosome microtubule organizing center cytoskeleton methyltransferase activity protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine methylation heat shock protein binding methylation macromolecular complex uc029rjq.1 uc029rjq.2 uc029rjq.3 
ENSMUST00000116234.9 Arl1 ENSMUST00000116234.9 ADP-ribosylation factor-like 1 (from RefSeq NM_025859.3) Arl1 ENSMUST00000116234.1 ENSMUST00000116234.2 ENSMUST00000116234.3 ENSMUST00000116234.4 ENSMUST00000116234.5 ENSMUST00000116234.6 ENSMUST00000116234.7 ENSMUST00000116234.8 NM_025859 Q14AC7 Q14AC7_MOUSE uc007grw.1 uc007grw.2 uc007grw.3 Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTPase activity GTP binding Golgi apparatus trans-Golgi network cytosol Golgi organization enzyme activator activity toxin metabolic process protein domain specific binding activation of phospholipase D activity protein localization to Golgi apparatus retrograde transport, endosome to Golgi Golgi vesicle transport uc007grw.1 uc007grw.2 uc007grw.3 
ENSMUST00000116259.5 Map7 ENSMUST00000116259.5 microtubule-associated protein 7, transcript variant 2 (from RefSeq NM_001198635.1) D3YWN7 D3YWN7_MOUSE ENSMUST00000116259.1 ENSMUST00000116259.2 ENSMUST00000116259.3 ENSMUST00000116259.4 Map7 Mtap7 NM_001198635 uc011xba.1 uc011xba.2 uc011xba.3 Belongs to the MAP7 family. microtubule cytoskeleton organization cytosol microtubule cytoskeleton axon uc011xba.1 uc011xba.2 uc011xba.3 
ENSMUST00000116273.9 Kdm1a ENSMUST00000116273.9 lysine (K)-specific demethylase 1A, transcript variant 2 (from RefSeq NM_133872.2) A3KG94 Aof2 ENSMUST00000116273.1 ENSMUST00000116273.2 ENSMUST00000116273.3 ENSMUST00000116273.4 ENSMUST00000116273.5 ENSMUST00000116273.6 ENSMUST00000116273.7 ENSMUST00000116273.8 KDM1A_MOUSE Kdm1a Kiaa0601 Lsd1 NM_133872 Q6PB53 Q6ZQ88 Q8VEA1 uc008vig.1 uc008vig.2 uc008vig.3 uc008vig.4 Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation (By similarity). Demethylates and stabilizes the DNA methylase DNMT1 (By similarity). Demethylates methylated 'Lys- 44' and methylated 'Lys-119' of SOX2 (By similarity). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. Reaction=2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]; Xref=Rhea:RHEA:60244, Rhea:RHEA-COMP:15540, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:16842, ChEBI:CHEBI:17499, ChEBI:CHEBI:29969, ChEBI:CHEBI:61976; EC=1.14.99.66; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; The N-terminal sequences of INSM1 and SNAI1 compete with histone H3 for the same binding site and thereby inhibit histone demethylation (in vitro). Component of a histone demethylase complex with RCOR1 (By similarity). Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B, KDM1A, RCOR1 and PHF21A. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, RCOR1 strongly enhances the demethylase activity and protects it from the proteasome while PHF21A inhibits the demethylase activity. Interacts with the androgen receptor (AR) (By similarity). Component of a RCOR/GFI/KDM1A/HDAC complex. Interacts directly with GFI1 and GFI1B (PubMed:17707228). Interacts with SNAI1 (via SNAG domain) (By similarity). Interacts with INSM1 (PubMed:24227653). Interacts (via AOD/Tower domain) with JADE2 (via C-terminus) (PubMed:25018020). Interacts with ESRRB; co-occupes the core set of ESRRB targets (PubMed:26206133). Interacts with SAMD1 (via WH domain); the interaction modulates KDM1A function (PubMed:33980486). Interacts with RBPJ (By similarity). Interacts with L3MBTL3 (By similarity). Interacts with ZMYND8 (By similarity). Q6ZQ88; P53566: Cebpa; NbExp=4; IntAct=EBI-1216284, EBI-2644207; Q6ZQ88; O09106: Hdac1; NbExp=7; IntAct=EBI-1216284, EBI-301912; Q6ZQ88; P70288: Hdac2; NbExp=4; IntAct=EBI-1216284, EBI-302251; Q6ZQ88; Q8CFE3: Rcor1; NbExp=2; IntAct=EBI-1216284, EBI-2337309; Q6ZQ88; Q9CQJ4: Rnf2; NbExp=3; IntAct=EBI-1216284, EBI-927321; Q6ZQ88; O35615: Zfpm1; NbExp=2; IntAct=EBI-1216284, EBI-4394596; Nucleus Ubiquitously expressed. Zygotic expression first appears at the morula stage. In blastocysts, expressed in the inner cell mass and trophectodermal cells. In postimplantation embryos, expression becomes ubiquitous. Down-regulated during neural differentiation. The SWIRM domain may act as an anchor site for a histone tail. Polyubiquitinated by JADE2; which leads to its proteasomal degradation. Deubiquitinated by USP38; preventing it from degradation by the 26S proteasome (By similarity). Promotes neural differentiation. Accelerated emergence of neural progenitors and mature neurons in differentiating embryonic stem cells. Belongs to the flavin monoamine oxidase family. Sequence=AAH59885.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC97980.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter nuclear chromosome, telomeric region nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor binding p53 binding positive regulation of neuroblast proliferation DNA binding chromatin binding protein binding nucleus nucleoplasm chromatin organization chromatin silencing regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein demethylation multicellular organism development transcription factor binding regulation of double-strand break repair via homologous recombination regulation of primitive erythrocyte differentiation positive regulation of neuron projection development oxidoreductase activity enzyme binding pituitary gland development cell differentiation ligand-dependent nuclear receptor transcription coactivator activity granulocyte differentiation negative regulation of protein binding demethylase activity histone demethylase activity histone demethylase activity (H3-K4 specific) histone demethylase activity (H3-K9 specific) macromolecular complex histone H3-K9 demethylation positive regulation of histone ubiquitination cellular response to UV histone demethylase activity (H3-dimethyl-K4 specific) histone H3-K4 demethylation positive regulation of chromatin binding telomeric DNA binding MRF binding negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of DNA damage response, signal transduction by p53 class mediator transcription regulatory region DNA binding positive regulation of erythrocyte differentiation positive regulation of megakaryocyte differentiation positive regulation of cell size negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter guanine metabolic process flavin adenine dinucleotide binding androgen receptor binding regulation of neurogenesis negative regulation of neurogenesis positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of histone H3-K4 methylation negative regulation of histone H3-K9 methylation muscle cell development oxidation-reduction process telomeric repeat-containing RNA binding cellular response to gamma radiation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of cellular protein localization neuron projection extension DNA repair complex positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation uc008vig.1 uc008vig.2 uc008vig.3 uc008vig.4 
ENSMUST00000116279.10 Mtfr1l ENSMUST00000116279.10 mitochondrial fission regulator 1-like, transcript variant 2 (from RefSeq NM_029759.4) ENSMUST00000116279.1 ENSMUST00000116279.2 ENSMUST00000116279.3 ENSMUST00000116279.4 ENSMUST00000116279.5 ENSMUST00000116279.6 ENSMUST00000116279.7 ENSMUST00000116279.8 ENSMUST00000116279.9 Fam54b MFR1L_MOUSE NM_029759 Q3UJK3 Q8BTP7 Q9CWE0 uc008vfj.1 uc008vfj.2 uc008vfj.3 uc008vfj.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CWE0-1; Sequence=Displayed; Name=2; IsoId=Q9CWE0-2; Sequence=VSP_034340; Belongs to the MTFR1 family. mitochondrial fission molecular_function mitochondrion aerobic respiration uc008vfj.1 uc008vfj.2 uc008vfj.3 uc008vfj.4 
ENSMUST00000116305.8 Gps1 ENSMUST00000116305.8 G protein pathway suppressor 1, transcript variant 7 (from RefSeq NM_001405274.1) ENSMUST00000116305.1 ENSMUST00000116305.2 ENSMUST00000116305.3 ENSMUST00000116305.4 ENSMUST00000116305.5 ENSMUST00000116305.6 ENSMUST00000116305.7 Gps1 NM_001405274 Q3MIA8 Q3MIA8_MOUSE uc007mup.1 uc007mup.2 uc007mup.3 uc007mup.4 Cytoplasm Nucleus Belongs to the CSN1 family. protein deneddylation COP9 signalosome uc007mup.1 uc007mup.2 uc007mup.3 uc007mup.4 
ENSMUST00000116341.4 Slc25a51 ENSMUST00000116341.4 solute carrier family 25, member 51 (from RefSeq NM_001009949.3) ENSMUST00000116341.1 ENSMUST00000116341.2 ENSMUST00000116341.3 Mcart1 NM_001009949 Q3U190 Q3UCW5 Q5HZI9 S2551_MOUSE Slc25a51 uc008ssr.1 uc008ssr.2 uc008ssr.3 uc008ssr.4 Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria. Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration. Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria. The transport mechanism, uniport or antiport, its electrogenicity and substrate selectivity, remain to be elucidated. Reaction=NAD(+)(in) = NAD(+)(out); Xref=Rhea:RHEA:65408, ChEBI:CHEBI:57540; Evidence=; Mitochondrion inner membrane ; Multi-pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. Sequence=BAE27432.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE29497.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE30612.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE31003.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE33610.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE38106.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; mitochondrion mitochondrial inner membrane membrane integral component of membrane uc008ssr.1 uc008ssr.2 uc008ssr.3 uc008ssr.4 
ENSMUST00000116345.3 Gm17193 ENSMUST00000116345.3 Gm17193 (from geneSymbol) ENSMUST00000116345.1 ENSMUST00000116345.2 uc288hwy.1 uc288hwy.2 uc288hwy.1 uc288hwy.2 
ENSMUST00000116349.9 Xylt2 ENSMUST00000116349.9 xylosyltransferase II (from RefSeq NM_145828.3) ENSMUST00000116349.1 ENSMUST00000116349.2 ENSMUST00000116349.3 ENSMUST00000116349.4 ENSMUST00000116349.5 ENSMUST00000116349.6 ENSMUST00000116349.7 ENSMUST00000116349.8 NM_145828 Q5SUY1 Q8K060 Q9EPL0 XYLT2_MOUSE uc007kzi.1 uc007kzi.2 uc007kzi.3 uc007kzi.4 Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN (PubMed:17517600). Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (By similarity). Reaction=L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)- L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:50192, Rhea:RHEA- COMP:9863, Rhea:RHEA-COMP:12567, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:132085; EC=2.4.2.26; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Active with either Mg(2+) or Mn(2+), but activity is highest when both are present. ; Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis. Monomer. Golgi apparatus membrane ; Single-pass type II membrane protein Secreted Detected in brain, liver, lung, kidney, heart, spleen and testis, and at lower levels in skeletal muscle. Contains disulfide bonds. Mutant mice are born at the expected Mendelian rate. Their livers display strongly reduced levels of heparan sulfate proteoglycan. DCN glycosylation is altered and lacks chondroitin sulfate groups. After 3 to 5 months, all mutant mice display increased liver weight. At an age of 4 to 5 months, about half of them delevop liver cysts, due to biliary epithelial cell hyperplasia. At an age of 3 and 10 months, mutant mice also display increased kidney weight due to hydronephrosis and impaired renal function, but they do not develop cysts. Belongs to the glycosyltransferase 14 family. XylT subfamily. Sequence=AAH34082.1; Type=Erroneous initiation; Evidence=; Golgi membrane magnesium ion binding extracellular region extracellular space Golgi apparatus glycosaminoglycan biosynthetic process acetylglucosaminyltransferase activity heparan sulfate proteoglycan biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups manganese ion binding protein xylosyltransferase activity proteoglycan biosynthetic process chondroitin sulfate biosynthetic process heparin biosynthetic process metal ion binding chondroitin sulfate proteoglycan biosynthetic process uc007kzi.1 uc007kzi.2 uc007kzi.3 uc007kzi.4 
ENSMUST00000116354.4 Zfp628 ENSMUST00000116354.4 zinc finger protein 628, transcript variant 1 (from RefSeq NM_170759.3) ENSMUST00000116354.1 ENSMUST00000116354.2 ENSMUST00000116354.3 NM_170759 Q3U2L5 Q6P5B3 Q8CJ78 ZN628_MOUSE Zec Zfp628 Znf628 uc009eyx.1 uc009eyx.2 uc009eyx.3 Transcriptional activator (PubMed:15556296, PubMed:31932482). Binds DNA on GT-box consensus sequence 5'-TTGGTT-3' (PubMed:15556296). Plays a role in spermiogenesis (PubMed:31932482). Interacts with TAF4B. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CJ78-1; Sequence=Displayed; Name=2; IsoId=Q8CJ78-2; Sequence=VSP_019825, VSP_019826; Expressed widely in testis, in both germline and somatic cells (PubMed:31932482). Seems to have particularly strong expression in meiotic spermatocytes, postmeiotic round spermatids and Sertoli cells (PubMed:31932482). Not detected in elongating spermatids or mature sperm (at protein level) (PubMed:31932482). Expressed in testis, ovary, spleen, lung, brain, liver and kidney (PubMed:15556296, PubMed:31932482). Expressed in D3 embryonic stem cells and F9 embryonal carcinoma cells (PubMed:15556296). During development, expression in the brain decreases gradually (PubMed:15556296). Shows increasing expression in testis from 16.5 dpc onwards, with maximum expression at postnatal day 21 (PubMed:31932482). Viable, with no gross morphological or behavioral phenotypes. Males are infertile with complete absence of mature sperm. Spermiogenesis arrests at the round spermatid stage, accompanied by extensive apoptosis within the seminiferous tubules. Expression of spermiogenesis-associated genes TNP1, TNP2, PRM1 and PRM2 in testis is significantly reduced. Sequence=AAH56945.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH62973.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAN63612.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009eyx.1 uc009eyx.2 uc009eyx.3 
ENSMUST00000116359.3 Ctc1 ENSMUST00000116359.3 CTS telomere maintenance complex component 1, transcript variant 1 (from RefSeq NM_001013256.2) B2RW14 CTC1_MOUSE ENSMUST00000116359.1 ENSMUST00000116359.2 NM_001013256 Q3UKQ1 Q5SUQ9 Q6P9S2 Q8BRK2 Q91WN0 Q9CW32 uc007jox.1 uc007jox.2 uc007jox.3 uc007jox.4 Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Involved in telomere maintenance. Involved in genome stability (By similarity). May be in involved in telomeric C-strand fill-in during late S/G2 phase (PubMed:22748632). Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1; in the complex interacts directly with STN1. Interacts with ACD and POT1 (By similarity). Nucleus romosome, telomere Note=A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5SUQ9-1; Sequence=Displayed; Name=2; IsoId=Q5SUQ9-2; Sequence=VSP_025355; Name=3; IsoId=Q5SUQ9-3; Sequence=VSP_025354; Belongs to the CTC1 family. Sequence=AAH14687.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH60629.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC30081.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE26750.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE38452.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; telomere maintenance chromosome, telomeric region nuclear chromosome, telomeric region DNA binding single-stranded DNA binding protein binding nucleus chromosome cellular response to DNA damage stimulus aging regulation of G2/M transition of mitotic cell cycle telomere maintenance via telomere lengthening negative regulation of telomere maintenance via telomerase multicellular organism growth telomeric DNA binding positive regulation of DNA replication positive regulation of fibroblast proliferation spleen development thymus development bone marrow development chromosome organization hematopoietic stem cell proliferation replicative senescence G-rich strand telomeric DNA binding CST complex uc007jox.1 uc007jox.2 uc007jox.3 uc007jox.4 
ENSMUST00000116363.2 Adprm ENSMUST00000116363.2 ADP-ribose/CDP-alcohol diphosphatase, manganese dependent (from RefSeq NM_025510.3) ADPRM_MOUSE ENSMUST00000116363.1 NM_025510 Q5SUD1 Q99KS6 Q9D7K9 uc007jlt.1 uc007jlt.2 uc007jlt.3 uc007jlt.4 Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP- glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity). Reaction=CDP-choline + H2O = CMP + 2 H(+) + phosphocholine; Xref=Rhea:RHEA:32487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:295975; EC=3.6.1.53; Reaction=ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+); Xref=Rhea:RHEA:10412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57967, ChEBI:CHEBI:78346, ChEBI:CHEBI:456215; EC=3.6.1.13; Reaction=ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+); Xref=Rhea:RHEA:10412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57967, ChEBI:CHEBI:78346, ChEBI:CHEBI:456215; EC=3.6.1.53; Reaction=CDP-glycerol + H2O = CMP + 2 H(+) + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:21692, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597, ChEBI:CHEBI:58311, ChEBI:CHEBI:60377; EC=3.6.1.16; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Monomer. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99KS6-1; Sequence=Displayed; Name=2; IsoId=Q99KS6-2; Sequence=VSP_025094, VSP_025095; Belongs to the ADPRibase-Mn family. molecular_function cellular_component biological_process hydrolase activity metal ion binding ADP-ribose diphosphatase activity CDP-glycerol diphosphatase activity uc007jlt.1 uc007jlt.2 uc007jlt.3 uc007jlt.4 
ENSMUST00000116375.2 Cstf1 ENSMUST00000116375.2 cleavage stimulation factor, 3' pre-RNA, subunit 1, transcript variant 3 (from RefSeq NM_024199.3) CSTF1_MOUSE ENSMUST00000116375.1 NM_024199 Q3UMB8 Q8BJW1 Q99LC2 Q9CSU8 uc008ocq.1 uc008ocq.2 uc008ocq.3 One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (By similarity). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity). Homodimer (By similarity). The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit) (By similarity). Interacts (via repeats WD) directly with CSTF3 (By similarity). Interacts (via repeat WD6) with BARD1 (By similarity). Interacts with ERCC6 (By similarity). Nucleus N-terminus mediates homodimerization. Sequence=BAB27929.1; Type=Frameshift; Evidence=; nucleus nucleoplasm mRNA cleavage stimulating factor complex mRNA processing uc008ocq.1 uc008ocq.2 uc008ocq.3 
ENSMUST00000116376.9 Sh3bp5l ENSMUST00000116376.9 SH3 binding domain protein 5 like, transcript variant 2 (from RefSeq NM_024480.5) 3BP5L_MOUSE ENSMUST00000116376.1 ENSMUST00000116376.2 ENSMUST00000116376.3 ENSMUST00000116376.4 ENSMUST00000116376.5 ENSMUST00000116376.6 ENSMUST00000116376.7 ENSMUST00000116376.8 Kiaa1720 NM_024480 Q3UMF7 Q8BUC2 Q91YX6 Q99LH9 uc007jbe.1 uc007jbe.2 uc007jbe.3 uc007jbe.4 uc007jbe.5 Functions as a guanine nucleotide exchange factor (GEF) for RAB11A. Belongs to the SH3BP5 family. protein kinase inhibitor activity guanyl-nucleotide exchange factor activity cytoplasm Rab guanyl-nucleotide exchange factor activity intracellular signal transduction negative regulation of protein tyrosine kinase activity uc007jbe.1 uc007jbe.2 uc007jbe.3 uc007jbe.4 uc007jbe.5 
ENSMUST00000116378.8 Zfp2 ENSMUST00000116378.8 zinc finger protein 2, transcript variant 7 (from RefSeq NM_001294323.1) ENSMUST00000116378.1 ENSMUST00000116378.2 ENSMUST00000116378.3 ENSMUST00000116378.4 ENSMUST00000116378.5 ENSMUST00000116378.6 ENSMUST00000116378.7 Fnp-2 Mkr2 NM_001294323 P08043 Q3V280 Q8R012 ZFP2_MOUSE Zfp-2 uc007isy.1 uc007isy.2 uc007isy.3 uc007isy.4 Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P08043-1; Sequence=Displayed; Name=2; IsoId=P08043-2; Sequence=VSP_026332; Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAE20918.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc007isy.1 uc007isy.2 uc007isy.3 uc007isy.4 
ENSMUST00000116380.9 Rpn2 ENSMUST00000116380.9 ribophorin II, transcript variant 2 (from RefSeq NM_019642.4) A2ACG6 ENSMUST00000116380.1 ENSMUST00000116380.2 ENSMUST00000116380.3 ENSMUST00000116380.4 ENSMUST00000116380.5 ENSMUST00000116380.6 ENSMUST00000116380.7 ENSMUST00000116380.8 NM_019642 Q3TKY0 Q91XH0 Q9DBG6 RPN2_MOUSE Rpn2 uc008now.1 uc008now.2 uc008now.3 Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Protein modification; protein glycosylation. Component of the oligosaccharyltransferase (OST) complex (By similarity). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (By similarity). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with DDI2 (By similarity). Interacts with TMEM35A/NACHO (PubMed:32783947). Endoplasmic reticulum Endoplasmic reticulum membrane; Multi- pass membrane protein Belongs to the SWP1 family. autophagosome membrane endoplasmic reticulum endoplasmic reticulum membrane rough endoplasmic reticulum protein glycosylation protein N-linked glycosylation aging oligosaccharyltransferase complex membrane integral component of membrane response to drug ribosome binding dolichyl-diphosphooligosaccharide-protein glycotransferase activity uc008now.1 uc008now.2 uc008now.3 
ENSMUST00000116389.9 Raly ENSMUST00000116389.9 hnRNP-associated with lethal yellow, transcript variant 6 (from RefSeq NM_001420807.1) A2AU63 ENSMUST00000116389.1 ENSMUST00000116389.2 ENSMUST00000116389.3 ENSMUST00000116389.4 ENSMUST00000116389.5 ENSMUST00000116389.6 ENSMUST00000116389.7 ENSMUST00000116389.8 Merc NM_001420807 Q64012 Q99K76 Q9CXH8 Q9QZX6 RALY_MOUSE uc008njv.1 uc008njv.2 uc008njv.3 RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver (PubMed:27251289). Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (PubMed:27251289). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (By similarity). Identified in the spliceosome C complex. Interacts (through its RNA-binding domain) with FUS (through its RNA-binding domain); both are components of the same RNPs. Q64012; Q61545: Ewsr1; NbExp=2; IntAct=EBI-6878379, EBI-1606991; Nucleus Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q64012-1; Sequence=Displayed; Name=1; IsoId=Q64012-2; Sequence=VSP_005805; Widely expressed. Expressed in brain, testis, lung, spleen and kidney. Weakly expressed in liver. Expressed in the unfertilized egg, in the blastocyst, as well as in the developing embryo and fetus. Expressed in developing skin. Note=Defects in Raly are the cause of lethal yellow mutation (A(y)), a dominant allele that cause embryonic lethality when homozygous, and pleiotropic effects when heterozygous, including yellow pelage, obesity, non-insulin dependent diabetes and increased tumor susceptibility. A(y) is due to a 170 kb deletion that removes all but the promoter and non-coding first exon of Raly and links them to the ASIP/Agouti gene. Belongs to the RRM HNRPC family. RALY subfamily. nucleic acid binding transcription cofactor activity RNA binding nucleus spliceosomal complex mRNA processing RNA splicing cholesterol homeostasis catalytic step 2 spliceosome regulation of nucleic acid-templated transcription uc008njv.1 uc008njv.2 uc008njv.3 
ENSMUST00000116412.8 Ctu2 ENSMUST00000116412.8 cytosolic thiouridylase subunit 2, transcript variant 2 (from RefSeq NR_152823.1) CTU2_MOUSE ENSMUST00000116412.1 ENSMUST00000116412.2 ENSMUST00000116412.3 ENSMUST00000116412.4 ENSMUST00000116412.5 ENSMUST00000116412.6 ENSMUST00000116412.7 NR_152823 Ncs2 Q3U308 Q8BTG9 Q8CI68 uc009nsz.1 uc009nsz.2 uc009nsz.3 Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. Cytoplasm Belongs to the CTU2/NCS2 family. Sequence=AAH36332.1; Type=Erroneous initiation; Evidence=; Sequence=BAC41181.1; Type=Frameshift; Evidence=; tRNA binding tRNA wobble uridine modification tRNA wobble position uridine thiolation cytoplasm cytosol tRNA processing nucleotidyltransferase activity sulfurtransferase activity protein urmylation macromolecular complex tRNA thio-modification uc009nsz.1 uc009nsz.2 uc009nsz.3 
ENSMUST00000116415.9 Mthfsd ENSMUST00000116415.9 methenyltetrahydrofolate synthetase domain containing, transcript variant 7 (from RefSeq NM_001372386.1) ENSMUST00000116415.1 ENSMUST00000116415.2 ENSMUST00000116415.3 ENSMUST00000116415.4 ENSMUST00000116415.5 ENSMUST00000116415.6 ENSMUST00000116415.7 ENSMUST00000116415.8 MTHSD_MOUSE NM_001372386 Q3URQ7 Q80WS4 Q8BUM0 uc009nro.1 uc009nro.2 uc009nro.3 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3URQ7-1; Sequence=Displayed; Name=2; IsoId=Q3URQ7-2; Sequence=VSP_027116; Name=3; IsoId=Q3URQ7-3; Sequence=VSP_027117, VSP_027118; nucleic acid binding RNA binding cytoplasm uc009nro.1 uc009nro.2 uc009nro.3 
ENSMUST00000116420.4 Trmt5 ENSMUST00000116420.4 TRM5 tRNA methyltransferase 5, transcript variant 1 (from RefSeq NM_029580.4) ENSMUST00000116420.1 ENSMUST00000116420.2 ENSMUST00000116420.3 Kiaa1393 NM_029580 Q5DTY1 Q9D0C4 TRM5_MOUSE Trm5 uc007nwg.1 uc007nwg.2 uc007nwg.3 Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. Reaction=guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)- methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:36899, Rhea:RHEA-COMP:10145, Rhea:RHEA-COMP:10147, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.228; Evidence=; Monomer. Mitochondrion matrix cleus Cytoplasm Note=Predominantly in the mitochondria and in the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D0C4-1; Sequence=Displayed; Name=2; IsoId=Q9D0C4-2; Sequence=VSP_021355; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family. tRNA N1-guanine methylation nucleus cytoplasm mitochondrion mitochondrial matrix tRNA processing methyltransferase activity tRNA methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity transferase activity tRNA methylation methylation tRNA (guanine(37)-N(1))-methyltransferase activity mitochondrial tRNA methylation uc007nwg.1 uc007nwg.2 uc007nwg.3 
ENSMUST00000116434.11 Zkscan3 ENSMUST00000116434.11 zinc finger with KRAB and SCAN domains 3, transcript variant 2 (from RefSeq NM_023685.5) A0A0R4J1L3 A0A0R4J1L3_MOUSE ENSMUST00000116434.1 ENSMUST00000116434.10 ENSMUST00000116434.2 ENSMUST00000116434.3 ENSMUST00000116434.4 ENSMUST00000116434.5 ENSMUST00000116434.6 ENSMUST00000116434.7 ENSMUST00000116434.8 ENSMUST00000116434.9 NM_023685 Zkscan3 uc007pqg.1 uc007pqg.2 uc007pqg.3 uc007pqg.4 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc007pqg.1 uc007pqg.2 uc007pqg.3 uc007pqg.4 
ENSMUST00000116436.9 Ahr ENSMUST00000116436.9 aryl-hydrocarbon receptor, transcript variant 1 (from RefSeq NM_013464.4) Ahr ENSMUST00000116436.1 ENSMUST00000116436.2 ENSMUST00000116436.3 ENSMUST00000116436.4 ENSMUST00000116436.5 ENSMUST00000116436.6 ENSMUST00000116436.7 ENSMUST00000116436.8 NM_013464 Q3U5D9 Q3U5D9_MOUSE uc007nji.1 uc007nji.2 uc007nji.3 The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Cytoplasm Nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated xenobiotic metabolic process response to xenobiotic stimulus aryl hydrocarbon receptor complex protein dimerization activity uc007nji.1 uc007nji.2 uc007nji.3 
ENSMUST00000116444.10 Hpca ENSMUST00000116444.10 hippocalcin, transcript variant 8 (from RefSeq NM_001421091.1) A2A7R4 ENSMUST00000116444.1 ENSMUST00000116444.2 ENSMUST00000116444.3 ENSMUST00000116444.4 ENSMUST00000116444.5 ENSMUST00000116444.6 ENSMUST00000116444.7 ENSMUST00000116444.8 ENSMUST00000116444.9 HPCA_MOUSE Hpca NM_001421091 P32076 P41211 P70510 P84075 uc008uwd.1 uc008uwd.2 uc008uwd.3 uc008uwd.4 uc008uwd.5 Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases. Oligomer; oligomerization is calcium-dependent. May interact with the voltage-dependent P/Q- and N-type calcium channels CACNA1A and CACNA1B. P84075; Q08460: Kcnma1; NbExp=3; IntAct=EBI-2128343, EBI-1633915; Cytoplasm, cytosol mbrane ; Peripheral membrane protein Note=Association with membranes is calcium-dependent (By similarity). Enriched in the perinuclear region, probably at the trans Golgi network in response to calcium (By similarity). Binds 3 calcium via EF-hand domains. The cryptic EF-hand 1 does not bind calcium. Myristoylation facilitates association with membranes. Belongs to the recoverin family. actin binding calcium ion binding protein binding cytoplasm cytosol brain development positive regulation of phospholipase activity response to organic cyclic compound membrane calcium-mediated signaling extrinsic component of membrane kinase binding axon negative regulation of guanylate cyclase activity activation of phospholipase D activity dendrite membrane neuronal cell body membrane dendrite cytoplasm identical protein binding perikaryon dendritic spine head positive regulation of adenylate cyclase activity metal ion binding inner ear development retina development in camera-type eye cellular response to electrical stimulus cellular response to calcium ion positive regulation of protein targeting to membrane postsynapse glutamatergic synapse regulation of voltage-gated calcium channel activity response to ketamine response to L-glutamate cellular response to monosodium glutamate response to Aroclor 1254 uc008uwd.1 uc008uwd.2 uc008uwd.3 uc008uwd.4 uc008uwd.5 
ENSMUST00000116456.10 Cyth3 ENSMUST00000116456.10 cytohesin 3, transcript variant 1 (from RefSeq NM_011182.4) Cyth3 ENSMUST00000116456.1 ENSMUST00000116456.2 ENSMUST00000116456.3 ENSMUST00000116456.4 ENSMUST00000116456.5 ENSMUST00000116456.6 ENSMUST00000116456.7 ENSMUST00000116456.8 ENSMUST00000116456.9 NM_011182 Pscd3 Q3TXK1 Q3TXK1_MOUSE uc009ako.1 uc009ako.2 uc009ako.3 uc009ako.4 ARF guanyl-nucleotide exchange factor activity phosphatidylinositol-3,4,5-trisphosphate binding nucleoplasm cytosol plasma membrane extrinsic component of cytoplasmic side of plasma membrane regulation of ARF protein signal transduction Golgi vesicle transport uc009ako.1 uc009ako.2 uc009ako.3 uc009ako.4 
ENSMUST00000116457.9 Cd82 ENSMUST00000116457.9 CD82 antigen, transcript variant 7 (from RefSeq NM_001271431.1) Cd82 ENSMUST00000116457.1 ENSMUST00000116457.2 ENSMUST00000116457.3 ENSMUST00000116457.4 ENSMUST00000116457.5 ENSMUST00000116457.6 ENSMUST00000116457.7 ENSMUST00000116457.8 NM_001271431 Q3UII2 Q3UII2_MOUSE uc008lfz.1 uc008lfz.2 uc008lfz.3 uc008lfz.4 Membrane ulti-pass membrane protein Belongs to the tetraspanin (TM4SF) family. plasma membrane membrane integral component of membrane uc008lfz.1 uc008lfz.2 uc008lfz.3 uc008lfz.4 
ENSMUST00000116468.2 Mphosph8 ENSMUST00000116468.2 M-phase phosphoprotein 8, transcript variant 3 (from RefSeq NR_153396.1) A6H600 ENSMUST00000116468.1 MPP8_MOUSE Mphosph8 Mpp8 NR_153396 Q3TWY7 Q3TYA6 uc011zmc.1 uc011zmc.2 uc011zmc.3 Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down- regulation of host gene expression. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. Homodimer. Interacts (via chromo domain) with histone H3K9me3. Has the highest affinity for H3K9me3, and lesser affinity for H3K9me2 and H3K9me1. Component of the HUSH complex; at least composed of TASOR, PPHLN1 and MPHOSPH8. Interacts with DNMT3, EHMT1 and SETDB1. Interacts with MORC2; the interaction associateS MORC2 with the HUSH complex which recruits MORC2 to heterochromatic loci. Interacts with ZNF638; leading to recruitment of the HUSH complex to unintegrated retroviral DNA (By similarity). Interacts with TASOR (PubMed:31112734). Nucleus Chromosome Note=Detected on heterochromatin (PubMed:23416073). Dissociates from chromatin during interphase and early mitosis (PubMed:23416073). Detected on nucleosomes (By similarity). Expressed in the spermatogonia, spermatocytes and granular cells within the cerebellum. The chromo domain mediates interaction with methylated 'Lys-9' of histone H3 (H3K9me), with the highest affinity for the trimethylated form (H3K9me3). Phosphorylated in M (mitotic) phase. Phosphorylation by CDK1 promotes dissociation from chromatin. Sequence=AAI45701.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nuclear nucleosome heterochromatin chromatin binding nucleus chromosome nuclear heterochromatin nucleolus cytoplasm cytosol plasma membrane methylated histone binding regulation of DNA methylation negative regulation of gene expression, epigenetic negative regulation of single stranded viral RNA replication via double stranded DNA intermediate negative regulation of transcription, DNA-templated positive regulation of methylation-dependent chromatin silencing uc011zmc.1 uc011zmc.2 uc011zmc.3 
ENSMUST00000116473.5 Gm45753 ENSMUST00000116473.5 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; (from UniProt A0A1C7CYU8) A0A1C7CYU8 A0A1C7CYU8_MOUSE ENSMUST00000116473.1 ENSMUST00000116473.2 ENSMUST00000116473.3 ENSMUST00000116473.4 Gm45753 M58588 uc291zok.1 uc291zok.2 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc291zok.1 uc291zok.2 
ENSMUST00000116495.8 Trappc2 ENSMUST00000116495.8 trafficking protein particle complex 2, transcript variant 1 (from RefSeq NM_025432.4) ENSMUST00000116495.1 ENSMUST00000116495.2 ENSMUST00000116495.3 ENSMUST00000116495.4 ENSMUST00000116495.5 ENSMUST00000116495.6 ENSMUST00000116495.7 NM_025432 Q8BP61 Q9CQF5 Q9CQP2 Q9D0V3 Q9DCM3 Sedl TPPC2_MOUSE uc009uws.1 uc009uws.2 uc009uws.3 uc009uws.4 Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with ENO1, PITX1, SF1 and TRAPPC2L (By similarity). Interacts with TRAPPC3. Q9CQP2; Q8K3V1: Spata4; NbExp=3; IntAct=EBI-1172267, EBI-7067375; Q9CQP2; Q96Q05: TRAPPC9; Xeno; NbExp=2; IntAct=EBI-1172267, EBI-6160596; Cytoplasm, perinuclear region Nucleus Endoplasmic reticulum-Golgi intermediate compartment Cytoplasm Note=Localized in perinuclear granular structures. Expressed in chondrocytes at various stages of differentiation, including proliferating, prehypertrophic and hypertrophic chondrocytes in the distal femoral joint. Belongs to the TRAPP small subunits family. Sedlin subfamily. skeletal system development protein binding nucleus nucleoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment regulation of transcription, DNA-templated ER to Golgi vesicle-mediated transport transcription factor binding vesicle-mediated transport TRAPP complex intracellular membrane-bounded organelle ion channel binding perinuclear region of cytoplasm uc009uws.1 uc009uws.2 uc009uws.3 uc009uws.4 
ENSMUST00000116514.4 Wbp11 ENSMUST00000116514.4 WW domain binding protein 11 (from RefSeq NM_021714.4) ENSMUST00000116514.1 ENSMUST00000116514.2 ENSMUST00000116514.3 NM_021714 O88539 Q3UMD8 Q8VDI0 Q923D5 Sipp1 WBP11_MOUSE uc009emf.1 uc009emf.2 uc009emf.3 uc009emf.4 Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. Interacts via the PGR motif with PQBP1 in the nucleus. Interacts with the WW domains of WBP4 (By similarity). Interacts with PPP1CA, PPP1CB and PPP1CC. Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin. Ubiquitously expressed, with highest levels in testis. Mutant embryos die prior to 8.5 dpc (PubMed:33276377). Heterozygous null mice are small and exhibit defects in axial skeleton, kidneys and esophagus (PubMed:33276377). Sequence=AAC34812.1; Type=Frameshift; Evidence=; nucleus nucleoplasm cytoplasm cytosol rRNA processing RNA processing mRNA processing RNA splicing nuclear speck protein phosphatase regulator activity intracellular membrane-bounded organelle regulation of phosphoprotein phosphatase activity mRNA cis splicing, via spliceosome WW domain binding nucleolus uc009emf.1 uc009emf.2 uc009emf.3 uc009emf.4 
ENSMUST00000116522.8 Nck1 ENSMUST00000116522.8 non-catalytic region of tyrosine kinase adaptor protein 1, transcript variant 1 (from RefSeq NM_010878.3) ENSMUST00000116522.1 ENSMUST00000116522.2 ENSMUST00000116522.3 ENSMUST00000116522.4 ENSMUST00000116522.5 ENSMUST00000116522.6 ENSMUST00000116522.7 NCK1_MOUSE NM_010878 O55032 Q99M51 Q9Z279 uc009rex.1 uc009rex.2 uc009rex.3 uc009rex.4 Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA (By similarity). Associates with BLNK, PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with SOCS7. This interaction is required for nuclear import. Part of a complex containing PPP1R15B, PP1 and NCK1. Interacts with RALGPS1. Interacts with CAV2 (tyrosine phosphorylated form). Interacts with ADAM15. Interacts with FASLG. Directly interacts with RASA1. Interacts with MINK1. Interacts with KDR (tyrosine phosphorylated). Interacts (via SH2 domain) with EPHB1; activates the JUN cascade to regulate cell adhesion. Interacts with EPHA2. Interacts (via SH2 domain) with PDGFRB (tyrosine phosphorylated). Interacts (via SH2 domain and SH3 domain 2) with EGFR. Interacts with PAK1 and SOS1. Interacts (via SH3 domains) with PKN2 (By similarity). Interacts with FLT1 (tyrosine phosphorylated). Interacts with the inactive form of EIF2AK2/PKR (By similarity). Interacts with PTPN1 (By similarity). Interacts with INSR/insulin receptor (in response to insulin stimulation); This interaction may mediate PTPN1 recruitment leading to INSR dephosphorylation (By similarity). Q99M51; P00520: Abl1; NbExp=2; IntAct=EBI-642202, EBI-914519; Q99M51; P97465: Dok1; NbExp=5; IntAct=EBI-642202, EBI-914917; Q99M51; O54967: Tnk2; NbExp=2; IntAct=EBI-642202, EBI-7780354; Cytoplasm Endoplasmic reticulum Nucleus Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments (By similarity). Only the first and third SH3 domains seem to be involved in RASA1-binding; the second SH3 domain and the SH2 domains do not seem to be involved. Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB (By similarity). protein phosphatase type 1 complex protein kinase inhibitor activity SH3/SH2 adaptor activity receptor binding protein binding nucleus cytoplasm endoplasmic reticulum ribosome cell-cell junction regulation of translation negative regulation of protein kinase activity substrate-dependent cell migration, cell extension actin filament organization positive regulation of neuron projection development vesicle membrane cell migration protein domain specific binding lamellipodium assembly regulation of cell migration positive regulation of actin filament polymerization receptor tyrosine kinase binding negative regulation of peptidyl-serine phosphorylation positive regulation of translation in response to endoplasmic reticulum stress positive regulation of T cell proliferation T cell activation positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin receptor signaling pathway ephrin receptor binding ephrin receptor signaling pathway response to other organism negative regulation of cell death peptidyl-serine dephosphorylation eukaryotic initiation factor eIF2 binding positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of cap-dependent translational initiation positive regulation of cap-independent translational initiation negative regulation of PERK-mediated unfolded protein response negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress uc009rex.1 uc009rex.2 uc009rex.3 uc009rex.4 
ENSMUST00000116527.2 Bex4 ENSMUST00000116527.2 brain expressed X-linked 4, transcript variant 1 (from RefSeq NM_212457.3) BEX4_MOUSE Bex4 ENSMUST00000116527.1 NM_212457 Q9CWT2 uc009uic.1 uc009uic.2 uc009uic.3 uc009uic.4 uc009uic.5 May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (PubMed:34562363). Interacts with alpha-tubulin. Interacts with SIRT2. Cytoplasm, cytoskeleton, spindle pole Nucleus Cytoplasm Note=Also localizes to microtubules. Expressed in both Sertoli and germ cells as well as interstitial area of the testis (at protein level). Up-regulated by cadmium in testis (at protein level) (PubMed:28295929). Up-regulated by curcumin (PubMed:28145533). Ubiquitinated and degraded by the proteasome. Belongs to the BEX family. spindle pole nucleus cytoplasm cytoskeleton microtubule chromosome segregation regulation of mitotic cell cycle regulation of cell migration regulation of cell proliferation histone deacetylase binding alpha-tubulin binding negative regulation of tubulin deacetylation uc009uic.1 uc009uic.2 uc009uic.3 uc009uic.4 uc009uic.5 
ENSMUST00000116547.3 Chic1 ENSMUST00000116547.3 cysteine-rich hydrophobic domain 1 (from RefSeq NM_009767.3) Brx CHIC1_MOUSE ENSMUST00000116547.1 ENSMUST00000116547.2 NM_009767 O08904 Q8CBW7 Q8K3S5 uc009tzl.1 uc009tzl.2 uc009tzl.3 uc009tzl.4 Cell membrane Cytoplasmic vesicle Note=Also present at a Golgi-like vesicular compartment and at scattered vesicles. Expressed moderately in the brain. Detected in the 7, 11, 15, or 19 dpc. Palmitoylated. Belongs to the CHIC family. It is uncertain whether Met-1 or Met-8 is the initiator. Sequence=BAC28706.1; Type=Frameshift; Evidence=; Sequence=CAA72638.1; Type=Frameshift; Evidence=; molecular_function plasma membrane membrane cytoplasmic vesicle uc009tzl.1 uc009tzl.2 uc009tzl.3 uc009tzl.4 
ENSMUST00000116553.9 Tmprss11f ENSMUST00000116553.9 transmembrane protease, serine 11f (from RefSeq NM_178730.3) ENSMUST00000116553.1 ENSMUST00000116553.2 ENSMUST00000116553.3 ENSMUST00000116553.4 ENSMUST00000116553.5 ENSMUST00000116553.6 ENSMUST00000116553.7 ENSMUST00000116553.8 Hatl4 NM_178730 Q8BHM9 TM11F_MOUSE uc008xxs.1 uc008xxs.2 uc008xxs.3 Probable serine protease. Membrane ; Single-pass type II membrane protein Belongs to the peptidase S1 family. serine-type endopeptidase activity extracellular region integral component of plasma membrane proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc008xxs.1 uc008xxs.2 uc008xxs.3 
ENSMUST00000116563.8 Klc2 ENSMUST00000116563.8 kinesin light chain 2, transcript variant 1 (from RefSeq NM_008451.3) ENSMUST00000116563.1 ENSMUST00000116563.2 ENSMUST00000116563.3 ENSMUST00000116563.4 ENSMUST00000116563.5 ENSMUST00000116563.6 ENSMUST00000116563.7 Klc2 NM_008451 Q91YS4 Q91YS4_MOUSE uc008gcg.1 uc008gcg.2 uc008gcg.3 Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport. Oligomeric complex composed of two heavy chains and two light chains. Cytoplasm, cytoskeleton Belongs to the kinesin light chain family. microtubule motor activity protein binding nucleoplasm mitochondrion cytosol kinesin complex plasma membrane macromolecular complex uc008gcg.1 uc008gcg.2 uc008gcg.3 
ENSMUST00000116567.4 Brms1 ENSMUST00000116567.4 breast cancer metastasis-suppressor 1, transcript variant 1 (from RefSeq NM_134155.3) BRMS1_MOUSE ENSMUST00000116567.1 ENSMUST00000116567.2 ENSMUST00000116567.3 NM_134155 Q99N20 uc008gbz.1 uc008gbz.2 uc008gbz.3 uc008gbz.4 Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity). Homohexamer (Potential). Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. Interacts with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3 (By similarity). Nucleus Cytoplasm Note=Predominantly nuclear. Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers. Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation. Belongs to the BRMS1 family. negative regulation of transcription from RNA polymerase II promoter protein binding nucleus cytoplasm apoptotic process cellular process histone deacetylation negative regulation of NF-kappaB transcription factor activity histone deacetylase binding regulation of apoptotic process negative regulation of transcription, DNA-templated NF-kappaB binding Sin3-type complex positive regulation of protein deacetylation positive regulation of anoikis histone deacetylase activity uc008gbz.1 uc008gbz.2 uc008gbz.3 uc008gbz.4 
ENSMUST00000116578.8 Renbp ENSMUST00000116578.8 renin binding protein, transcript variant 8 (from RefSeq NR_189639.1) A0A8Z1SL50 A0A8Z1SL50_MOUSE ENSMUST00000116578.1 ENSMUST00000116578.2 ENSMUST00000116578.3 ENSMUST00000116578.4 ENSMUST00000116578.5 ENSMUST00000116578.6 ENSMUST00000116578.7 NR_189639 Renbp uc009tnj.1 uc009tnj.2 uc009tnj.3 Reaction=an N-acyl-D-glucosamine = an N-acyl-D-mannosamine; Xref=Rhea:RHEA:19033, ChEBI:CHEBI:16062, ChEBI:CHEBI:17274; EC=5.1.3.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19034; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:19035; Evidence=; Amino-sugar metabolism; N-acetylneuraminate degradation. Belongs to the N-acylglucosamine 2-epimerase family. uc009tnj.1 uc009tnj.2 uc009tnj.3 
ENSMUST00000116584.2 Mrpl39 ENSMUST00000116584.2 mitochondrial ribosomal protein L39, transcript variant 1 (from RefSeq NM_017404.5) A6X954 ENSMUST00000116584.1 NM_017404 Q91YK5 Q9D8U5 Q9JKF7 RM39_MOUSE uc007zte.1 uc007zte.2 uc007zte.3 uc007zte.4 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mL39 family. Sequence=AAF44697.1; Type=Frameshift; Evidence=; Sequence=AAH12274.1; Type=Erroneous initiation; Evidence=; Sequence=AAH16561.1; Type=Erroneous initiation; Evidence=; Sequence=BAB25185.1; Type=Erroneous initiation; Evidence=; mitochondrial genome maintenance nucleotide binding structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation uc007zte.1 uc007zte.2 uc007zte.3 uc007zte.4 
ENSMUST00000116594.9 Sfmbt2 ENSMUST00000116594.9 Scm-like with four mbt domains 2, transcript variant 1 (from RefSeq NM_177386.5) ENSMUST00000116594.1 ENSMUST00000116594.2 ENSMUST00000116594.3 ENSMUST00000116594.4 ENSMUST00000116594.5 ENSMUST00000116594.6 ENSMUST00000116594.7 ENSMUST00000116594.8 NM_177386 Q3UH07 Q3UH07_MOUSE Sfmbt2 uc008ihy.1 uc008ihy.2 uc008ihy.3 uc008ihy.4 Nucleus transcription corepressor activity nucleus regulation of transcription, DNA-templated histone binding negative regulation of nucleic acid-templated transcription uc008ihy.1 uc008ihy.2 uc008ihy.3 uc008ihy.4 
ENSMUST00000116605.8 Mad2l1 ENSMUST00000116605.8 Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (By similarity). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, and recruits an open conformation of MAD2L1 (O- MAD2) which then promotes the conversion of O-MAD2 to C-MAD2 (By similarity). Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (By similarity). (from UniProt Q9Z1B5) AK160286 ENSMUST00000116605.1 ENSMUST00000116605.2 ENSMUST00000116605.3 ENSMUST00000116605.4 ENSMUST00000116605.5 ENSMUST00000116605.6 ENSMUST00000116605.7 MD2L1_MOUSE Mad2a Q9JI53 Q9Z1B5 uc009ceo.1 uc009ceo.2 uc009ceo.3 Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (By similarity). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, and recruits an open conformation of MAD2L1 (O- MAD2) which then promotes the conversion of O-MAD2 to C-MAD2 (By similarity). Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (By similarity). Monomer and homodimer (By similarity). Heterodimerizes with MAD2L1 in order to form a tetrameric MAD1L1-MAD2L1 core complex (By similarity). In the closed and open conformation, interacts with MAD1L1 (By similarity). Formation of a heterotetrameric core complex containing two molecules each of MAD1L1 and of MAD2L1 promotes binding of another molecule of MAD2L1 to each MAD2L1, resulting in a heterohexamer (By similarity). Interacts with MAD2L1BP (By similarity). Interacts with ADAM17/TACE (By similarity). Interacts with CDC20 (By similarity). Dimeric MAD2L1 in the closed conformation interacts with CDC20 (By similarity). Monomeric MAD2L1 in the open conformation does not interact with CDC20 (By similarity). CDC20 competes with MAD1L1 for MAD2L1 binding (By similarity). In the closed conformation, interacts with BUB1B (By similarity). Interacts with TTK (By similarity). Interacts with TPR (By similarity). Binds to UBD (via ubiquitin-like 1 domain) during mitosis (By similarity). Interacts with isoform 1 and isoform 2 of NEK2 (By similarity). Interacts with HSF1; this interaction occurs in mitosis (By similarity). Q9Z1B5; Q7TSY8: Sgo2; NbExp=3; IntAct=EBI-2552918, EBI-2552468; Q9Z1B5; Q9NRI5: DISC1; Xeno; NbExp=2; IntAct=EBI-2552918, EBI-529989; Nucleus Chromosome, centromere, kinetochore Cytoplasm Cytoplasm, cytoskeleton, spindle pole Note=Recruited by MAD1L1 to unattached kinetochores (By similarity). Recruited to the nuclear pore complex by TPR during interphase (By similarity). Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2 (By similarity). The protein has two highly different native conformations, an inactive open conformation that cannot bind CDC20 and that predominates in cytosolic monomers, and an active closed conformation. The protein in the closed conformation preferentially dimerizes with another molecule in the open conformation, but can also form a dimer with a molecule in the closed conformation. Formation of a heterotetrameric core complex containing two molecules of MAD1L1 and of MAD2L1 in the closed conformation promotes binding of another molecule of MAD2L1 in the open conformation and the conversion of the open to the closed form, and thereby promotes interaction with CDC20 (By similarity). Phosphorylated on multiple serine residues. The level of phosphorylation varies during the cell cycle and is highest during mitosis. Phosphorylation abolishes interaction with MAD1L1 and reduces interaction with CDC20. Phosphorylated by NEK2 (By similarity). Belongs to the MAD2 family. mitotic sister chromatid segregation establishment of mitotic spindle orientation chromosome, centromeric region kinetochore condensed chromosome kinetochore spindle pole protein binding nucleus nucleoplasm chromosome cytoplasm cytosol cytoskeleton cell cycle mitotic cell cycle checkpoint mitotic spindle assembly checkpoint protein C-terminus binding negative regulation of protein catabolic process identical protein binding protein homodimerization activity negative regulation of apoptotic process nuclear pore nuclear basket negative regulation of mitotic metaphase/anaphase transition negative regulation of mitotic cell cycle perinuclear region of cytoplasm cell division establishment of centrosome localization mitotic spindle positive regulation of mitotic cell cycle spindle assembly checkpoint negative regulation of ubiquitin protein ligase activity uc009ceo.1 uc009ceo.2 uc009ceo.3 
ENSMUST00000116614.3 Tesl1 ENSMUST00000116614.3 testin LIM domain protein like 1, transcript variant 2 (from RefSeq NM_001418376.1) B1AXB9 B1AXB9_MOUSE EG236749 ENSMUST00000116614.1 ENSMUST00000116614.2 Gm4907 NM_001418376 Tesl1 uc012hfi.1 uc012hfi.2 uc012hfi.3 Cell junction, focal adhesion Belongs to the prickle / espinas / testin family. molecular_function cellular_component biological_process zinc ion binding regulation of cell proliferation metal ion binding uc012hfi.1 uc012hfi.2 uc012hfi.3 
ENSMUST00000116615.5 Barx2 ENSMUST00000116615.5 BarH-like homeobox 2 (from RefSeq NM_013800.2) BARX2_MOUSE ENSMUST00000116615.1 ENSMUST00000116615.2 ENSMUST00000116615.3 ENSMUST00000116615.4 NM_013800 O08686 Q80ZF9 Q921G1 uc009oru.1 uc009oru.2 uc009oru.3 Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia. Nucleus. Nervous system, particularly in the telencephalon, spinal cord, and dorsal root ganglia. Highly expressed in small groups of cells undergoing tissue remodeling, such as ectodermal cells within indentations surrounding the eye and maxillo-nasal groove and in the first branchial pouch, lung buds, precartilagenous condensations, and mesenchyme of the limb. At 9.5 dpc, expressed only to head, prominent in the region of telencephalon and mesencephalon, and concentrated in cells along the dorsal midline. At 10.5 dpc, expression is moderated in the most rostral regions of the head, but particularly prominent in a lateral band of cells in the periocular region. At 11.5 dpc, detected in the telencephalon, frontonasal region and limbs. At 12.5 dpc, expressed in the telencephalon and hindbrain. Belongs to the BAR homeobox family. Sequence=AAB53146.1; Type=Erroneous initiation; Evidence=; Sequence=AAH12684.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cartilage condensation DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter tissue development myotube differentiation sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter animal organ development uc009oru.1 uc009oru.2 uc009oru.3 
ENSMUST00000116621.2 Ndufb11 ENSMUST00000116621.2 NADH:ubiquinone oxidoreductase subunit B11, transcript variant 1 (from RefSeq NM_019435.5) ENSMUST00000116621.1 NDUBB_MOUSE NM_019435 Np15 O09111 uc009ste.1 uc009ste.2 uc009ste.3 uc009ste.4 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Interacts with BCAP31. Mitochondrion inner membrane ; Single-pass membrane protein Note=The interaction with BCAP31 mediates mitochondria localization. Belongs to the complex I NDUFB11 subunit family. Sequence=AAH27265.1; Type=Erroneous initiation; Evidence=; Sequence=BAC25760.1; Type=Erroneous initiation; Evidence=; Sequence=CAA69961.1; Type=Erroneous initiation; Evidence=; molecular_function mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I membrane integral component of membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc009ste.1 uc009ste.2 uc009ste.3 uc009ste.4 
ENSMUST00000116639.4 Prr16 ENSMUST00000116639.4 proline rich 16 (from RefSeq NM_001081224.2) A3KMN5 ENSMUST00000116639.1 ENSMUST00000116639.2 ENSMUST00000116639.3 LARGN_MOUSE NM_001081224 Q8BLB9 uc008ewz.1 uc008ewz.2 uc008ewz.3 Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration (Probable). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A3KMN5-1; Sequence=Displayed; Name=2; IsoId=A3KMN5-2; Sequence=VSP_028882; Overexpression causes embryonic lethality. Conditional overexpression leads to increased cell size (PubMed:24656129). molecular_function cellular_component positive regulation of translation positive regulation of cell size uc008ewz.1 uc008ewz.2 uc008ewz.3 
ENSMUST00000116641.9 Lmf1 ENSMUST00000116641.9 lipase maturation factor 1, transcript variant 1 (from RefSeq NM_029624.5) ENSMUST00000116641.1 ENSMUST00000116641.2 ENSMUST00000116641.3 ENSMUST00000116641.4 ENSMUST00000116641.5 ENSMUST00000116641.6 ENSMUST00000116641.7 ENSMUST00000116641.8 LMF1_MOUSE NM_029624 Q3TDV1 Q3U3R4 Q8BM33 Q8BY75 Q8VDX3 Q9CWX8 Tmem112 uc033hbx.1 uc033hbx.2 uc033hbx.3 Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL. Interacts with LPL and SEL1L. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3U3R4-1; Sequence=Displayed; Name=2; IsoId=Q3U3R4-2; Sequence=VSP_022974; Name=3; IsoId=Q3U3R4-3; Sequence=VSP_022973; Name=4; IsoId=Q3U3R4-4; Sequence=VSP_022975, VSP_022976; Expressed in all tissues synthesizing lipoprotein lipase (Lpl) and hepatic lipase (Lipc), including adipose tissue, skeletal muscle, heart, and liver. Expressed at higher levels in tissues that express little or no lipase activity such as testis and pancreas suggesting additional functions in these tissues. Note=Defects in Lmf1 are the cause of combined lipase deficiency (cld). Cld is characterized by severe hypertriglyceridemia with accumulation of chylomicrons that gradually pack the lumina of capillaries and sinusoids. Severe hypertriglyceridemia causes an increase in blood viscosity, ischemia, and cyanosis, and the inability of tissues to access circulating triglycerides results in starvation, poor thermoregulation, and death 2 to 3 days after birth. The disorder is caused by a decrease in the activity of lipoprotein lipase (Lpl) and the related hepatic lipase (Lipc), caused by impaired maturation of nascent Lpl and hepatic lipase polypeptides in the endoplasmic reticulum. Belongs to the lipase maturation factor family. Additional evidence for its localization to the endoplasmic reticulum membrane was found. However this paper was retracted due to manipulation of data. protein binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus triglyceride metabolic process ER to Golgi vesicle-mediated transport protein secretion membrane integral component of membrane protein glycosylation in Golgi chylomicron remnant clearance positive regulation of lipoprotein lipase activity protein maturation regulation of cholesterol metabolic process regulation of triglyceride metabolic process uc033hbx.1 uc033hbx.2 uc033hbx.3 
ENSMUST00000116643.4 Spin2-ps1 ENSMUST00000116643.4 spindlin family, member 2, pseudogene 1 (from RefSeq NM_029106.2) ENSMUST00000116643.1 ENSMUST00000116643.2 ENSMUST00000116643.3 NM_029106 uc292muq.1 uc292muq.2 uc292muq.3 uc292muq.1 uc292muq.2 uc292muq.3 
ENSMUST00000116681.3 Mir1298 ENSMUST00000116681.3 microRNA 1298 (from RefSeq NR_037210.1) ENSMUST00000116681.1 ENSMUST00000116681.2 NR_037210 uc012hqc.1 uc012hqc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609663.1 [ECO:0000345] ##Evidence-Data-END## uc012hqc.1 uc012hqc.2 
ENSMUST00000116685.3 Gm50451 ENSMUST00000116685.3 Gm50451 (from geneSymbol) ENSMUST00000116685.1 ENSMUST00000116685.2 MS824878 uc290tom.1 uc290tom.2 uc290tom.1 uc290tom.2 
ENSMUST00000116702.3 Gm26247 ENSMUST00000116702.3 Gm26247 (from geneSymbol) AK053743 ENSMUST00000116702.1 ENSMUST00000116702.2 uc291pdo.1 uc291pdo.2 uc291pdo.1 uc291pdo.2 
ENSMUST00000116706.3 Mir1247 ENSMUST00000116706.3 microRNA 1247 (from RefSeq NR_037204.1) ENSMUST00000116706.1 ENSMUST00000116706.2 NR_037204 uc011yup.1 uc011yup.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609641.1 [ECO:0000345] ##Evidence-Data-END## uc011yup.1 uc011yup.2 
ENSMUST00000116708.3 Gm26249 ENSMUST00000116708.3 Gm26249 (from geneSymbol) ENSMUST00000116708.1 ENSMUST00000116708.2 uc292gta.1 uc292gta.2 uc292gta.1 uc292gta.2 
ENSMUST00000116714.3 Gm25777 ENSMUST00000116714.3 Gm25777 (from geneSymbol) ENSMUST00000116714.1 ENSMUST00000116714.2 uc289dbv.1 uc289dbv.2 uc289dbv.1 uc289dbv.2 
ENSMUST00000116715.3 Gm25776 ENSMUST00000116715.3 Gm25776 (from geneSymbol) ENSMUST00000116715.1 ENSMUST00000116715.2 uc288iji.1 uc288iji.2 uc288iji.1 uc288iji.2 
ENSMUST00000116723.3 Snord88c ENSMUST00000116723.3 small nucleolar RNA, C/D box 88C (from RefSeq NR_028534.2) ENSMUST00000116723.1 ENSMUST00000116723.2 NR_028534 uc291pdr.1 uc291pdr.2 uc291pdr.1 uc291pdr.2 
ENSMUST00000116724.3 Gm22953 ENSMUST00000116724.3 Gm22953 (from geneSymbol) ENSMUST00000116724.1 ENSMUST00000116724.2 LF193531 uc289zym.1 uc289zym.2 uc289zym.1 uc289zym.2 
ENSMUST00000116728.4 Gm25309 ENSMUST00000116728.4 Gm25309 (from geneSymbol) ENSMUST00000116728.1 ENSMUST00000116728.2 ENSMUST00000116728.3 uc291zqb.1 uc291zqb.2 uc291zqb.1 uc291zqb.2 
ENSMUST00000116734.3 Gm22105 ENSMUST00000116734.3 Gm22105 (from geneSymbol) ENSMUST00000116734.1 ENSMUST00000116734.2 LF197966 uc287qpu.1 uc287qpu.2 uc287qpu.1 uc287qpu.2 
ENSMUST00000116746.3 Snord111 ENSMUST00000116746.3 small nucleolar RNA, C/D box 111 (from RefSeq NR_028559.1) ENSMUST00000116746.1 ENSMUST00000116746.2 NR_028559 uc012gkp.1 uc012gkp.2 uc012gkp.3 uc012gkp.1 uc012gkp.2 uc012gkp.3 
ENSMUST00000116756.3 Mir1188 ENSMUST00000116756.3 microRNA 1188 (from RefSeq NR_035419.1) ENSMUST00000116756.1 ENSMUST00000116756.2 NR_035419 uc011ysr.1 uc011ysr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610093.1 [ECO:0000345] ##Evidence-Data-END## uc011ysr.1 uc011ysr.2 
ENSMUST00000116759.3 Mir467h ENSMUST00000116759.3 microRNA 467h (from RefSeq NR_130329.1) ENSMUST00000116759.1 ENSMUST00000116759.2 NR_130329 uc057aqj.1 uc057aqj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057aqj.1 uc057aqj.2 
ENSMUST00000116761.3 Mir1193 ENSMUST00000116761.3 microRNA 1193 (from RefSeq NR_035424.1) ENSMUST00000116761.1 ENSMUST00000116761.2 NR_035424 uc011yti.1 uc011yti.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610098.1 [ECO:0000345] ##Evidence-Data-END## uc011yti.1 uc011yti.2 
ENSMUST00000116763.3 Gm26473 ENSMUST00000116763.3 Gm26473 (from geneSymbol) ENSMUST00000116763.1 ENSMUST00000116763.2 uc291mae.1 uc291mae.2 uc291mae.1 uc291mae.2 
ENSMUST00000116774.3 Mir466k ENSMUST00000116774.3 microRNA 466k (from RefSeq NR_130326.1) ENSMUST00000116774.1 ENSMUST00000116774.2 NR_130326 uc056ztb.1 uc056ztb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056ztb.1 uc056ztb.2 
ENSMUST00000116775.3 Gm24833 ENSMUST00000116775.3 Gm24833 (from geneSymbol) ENSMUST00000116775.1 ENSMUST00000116775.2 uc288xrm.1 uc288xrm.2 uc288xrm.1 uc288xrm.2 
ENSMUST00000116778.3 Gm24831 ENSMUST00000116778.3 Gm24831 (from geneSymbol) ENSMUST00000116778.1 ENSMUST00000116778.2 uc292qfe.1 uc292qfe.2 uc292qfe.1 uc292qfe.2 
ENSMUST00000116787.3 Gm24274 ENSMUST00000116787.3 Gm24274 (from geneSymbol) ENSMUST00000116787.1 ENSMUST00000116787.2 uc292ahv.1 uc292ahv.2 uc292ahv.1 uc292ahv.2 
ENSMUST00000116790.3 Gm25848 ENSMUST00000116790.3 Gm25848 (from geneSymbol) ENSMUST00000116790.1 ENSMUST00000116790.2 uc289ecm.1 uc289ecm.2 uc289ecm.1 uc289ecm.2 
ENSMUST00000116791.3 Mir1249 ENSMUST00000116791.3 microRNA 1249 (from RefSeq NR_037206.1) ENSMUST00000116791.1 ENSMUST00000116791.2 NR_037206 uc011zxj.1 uc011zxj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609651.1 [ECO:0000345] ##Evidence-Data-END## uc011zxj.1 uc011zxj.2 
ENSMUST00000116802.5 Mir1306 ENSMUST00000116802.5 microRNA 1306 (from RefSeq NR_035467.2) ENSMUST00000116802.1 ENSMUST00000116802.2 ENSMUST00000116802.3 ENSMUST00000116802.4 NR_035467 uc012acd.1 uc012acd.2 uc012acd.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610470.1 [ECO:0000345] ##Evidence-Data-END## uc012acd.1 uc012acd.2 uc012acd.3 
ENSMUST00000116804.6 Gm24195 ENSMUST00000116804.6 predicted gene, 24195 (from RefSeq NR_162773.1) ENSMUST00000116804.1 ENSMUST00000116804.2 ENSMUST00000116804.3 ENSMUST00000116804.4 ENSMUST00000116804.5 NR_162773 uc288mxz.1 uc288mxz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288mxz.1 uc288mxz.2 
ENSMUST00000116809.3 Mir669g ENSMUST00000116809.3 microRNA 669g (from RefSeq NR_035411.1) ENSMUST00000116809.1 ENSMUST00000116809.2 NR_035411 uc012bpl.1 uc012bpl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610085.1 [ECO:0000345] ##Evidence-Data-END## uc012bpl.1 uc012bpl.2 
ENSMUST00000116811.3 Gm22488 ENSMUST00000116811.3 Gm22488 (from geneSymbol) ENSMUST00000116811.1 ENSMUST00000116811.2 LF200258 uc288yed.1 uc288yed.2 uc288yed.1 uc288yed.2 
ENSMUST00000116813.3 Gm22489 ENSMUST00000116813.3 Gm22489 (from geneSymbol) ENSMUST00000116813.1 ENSMUST00000116813.2 uc287nbz.1 uc287nbz.2 uc287nbz.1 uc287nbz.2 
ENSMUST00000116815.3 Snord94 ENSMUST00000116815.3 Snord94 (from geneSymbol) ENSMUST00000116815.1 ENSMUST00000116815.2 LF195562 uc291fsg.1 uc291fsg.2 uc291fsg.1 uc291fsg.2 
ENSMUST00000116818.4 Mir1195 ENSMUST00000116818.4 microRNA 1195 (from RefSeq NR_035427.2) ENSMUST00000116818.1 ENSMUST00000116818.2 ENSMUST00000116818.3 NR_035427 uc056zfk.1 uc056zfk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zfk.1 uc056zfk.2 
ENSMUST00000116819.3 Snord98 ENSMUST00000116819.3 Snord98 (from geneSymbol) AF357358 ENSMUST00000116819.1 ENSMUST00000116819.2 uc029qyd.1 uc029qyd.2 uc029qyd.3 uc029qyd.1 uc029qyd.2 uc029qyd.3 
ENSMUST00000116828.3 Snord23 ENSMUST00000116828.3 small nucleolar RNA, C/D box 23 (from RefSeq NR_028539.1) ENSMUST00000116828.1 ENSMUST00000116828.2 NR_028539 uc012faa.1 uc012faa.2 uc012faa.3 uc012faa.1 uc012faa.2 uc012faa.3 
ENSMUST00000116830.3 Gm23494 ENSMUST00000116830.3 Gm23494 (from geneSymbol) ENSMUST00000116830.1 ENSMUST00000116830.2 uc292cnl.1 uc292cnl.2 uc292cnl.1 uc292cnl.2 
ENSMUST00000116849.3 Gm25338 ENSMUST00000116849.3 Gm25338 (from geneSymbol) ENSMUST00000116849.1 ENSMUST00000116849.2 uc289vze.1 uc289vze.2 uc289vze.1 uc289vze.2 
ENSMUST00000116853.3 Snord88a ENSMUST00000116853.3 small nucleolar RNA, C/D box 88A (from RefSeq NR_028533.1) ENSMUST00000116853.1 ENSMUST00000116853.2 NR_028533 uc012fjl.1 uc012fjl.2 uc012fjl.3 uc012fjl.1 uc012fjl.2 uc012fjl.3 
ENSMUST00000116854.3 Mir669d-2 ENSMUST00000116854.3 microRNA 669d-2 (from RefSeq NR_130334.1) ENSMUST00000116854.1 ENSMUST00000116854.2 NR_130334 uc056zjo.1 uc056zjo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zjo.1 uc056zjo.2 
ENSMUST00000116867.3 Gm23109 ENSMUST00000116867.3 Gm23109 (from geneSymbol) ENSMUST00000116867.1 ENSMUST00000116867.2 uc287xdj.1 uc287xdj.2 uc287xdj.1 uc287xdj.2 
ENSMUST00000116868.3 Gm22193 ENSMUST00000116868.3 Gm22193 (from geneSymbol) ENSMUST00000116868.1 ENSMUST00000116868.2 uc292dey.1 uc292dey.2 uc292dey.1 uc292dey.2 
ENSMUST00000116874.3 Gm23879 ENSMUST00000116874.3 Gm23879 (from geneSymbol) ENSMUST00000116874.1 ENSMUST00000116874.2 uc287izp.1 uc287izp.2 uc287izp.1 uc287izp.2 
ENSMUST00000116876.3 Mir466j ENSMUST00000116876.3 microRNA 466j (from RefSeq NR_130327.1) ENSMUST00000116876.1 ENSMUST00000116876.2 NR_130327 uc056ygy.1 uc056ygy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056ygy.1 uc056ygy.2 
ENSMUST00000116883.3 Mir1191 ENSMUST00000116883.3 microRNA 1191 (from RefSeq NR_035422.1) ENSMUST00000116883.1 ENSMUST00000116883.2 NR_035422 uc057ago.1 uc057ago.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057ago.1 uc057ago.2 
ENSMUST00000116886.3 Gm25539 ENSMUST00000116886.3 Gm25539 (from geneSymbol) ENSMUST00000116886.1 ENSMUST00000116886.2 uc291klc.1 uc291klc.2 uc291klc.1 uc291klc.2 
ENSMUST00000116888.3 Gm25541 ENSMUST00000116888.3 Gm25541 (from geneSymbol) ENSMUST00000116888.1 ENSMUST00000116888.2 uc289uji.1 uc289uji.2 uc289uji.1 uc289uji.2 
ENSMUST00000116889.4 Gm25542 ENSMUST00000116889.4 Gm25542 (from geneSymbol) ENSMUST00000116889.1 ENSMUST00000116889.2 ENSMUST00000116889.3 uc287iyo.1 uc287iyo.2 uc287iyo.1 uc287iyo.2 
ENSMUST00000116890.4 Gm22711 ENSMUST00000116890.4 Gm22711 (from geneSymbol) ENSMUST00000116890.1 ENSMUST00000116890.2 ENSMUST00000116890.3 uc288daf.1 uc288daf.2 uc288daf.1 uc288daf.2 
ENSMUST00000116892.3 Rnu4atac ENSMUST00000116892.3 Rnu4atac (from geneSymbol) AK050598 ENSMUST00000116892.1 ENSMUST00000116892.2 uc287lcj.1 uc287lcj.2 uc287lcj.1 uc287lcj.2 
ENSMUST00000116895.3 Gm22713 ENSMUST00000116895.3 Gm22713 (from geneSymbol) ENSMUST00000116895.1 ENSMUST00000116895.2 uc290jjf.1 uc290jjf.2 uc290jjf.1 uc290jjf.2 
ENSMUST00000116916.3 Gm26044 ENSMUST00000116916.3 Gm26044 (from geneSymbol) ENSMUST00000116916.1 ENSMUST00000116916.2 uc290wej.1 uc290wej.2 uc290wej.1 uc290wej.2 
ENSMUST00000116923.3 Mir467f ENSMUST00000116923.3 microRNA 467f (from RefSeq NR_035420.1) ENSMUST00000116923.1 ENSMUST00000116923.2 NR_035420 uc056ylw.1 uc056ylw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056ylw.1 uc056ylw.2 
ENSMUST00000116924.3 Mir466i ENSMUST00000116924.3 microRNA 466i (from RefSeq NR_035412.1) ENSMUST00000116924.1 ENSMUST00000116924.2 NR_035412 uc011ywl.1 uc011ywl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011ywl.1 uc011ywl.2 
ENSMUST00000116925.4 Mir1190 ENSMUST00000116925.4 microRNA 1190 (from RefSeq NR_035421.2) ENSMUST00000116925.1 ENSMUST00000116925.2 ENSMUST00000116925.3 NR_035421 uc011yqe.1 uc011yqe.2 uc011yqe.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011yqe.1 uc011yqe.2 uc011yqe.3 
ENSMUST00000116927.3 Gm23226 ENSMUST00000116927.3 Gm23226 (from geneSymbol) ENSMUST00000116927.1 ENSMUST00000116927.2 uc287zvl.1 uc287zvl.2 uc287zvl.1 uc287zvl.2 
ENSMUST00000116930.3 Mir466f-4 ENSMUST00000116930.3 microRNA 466f-4 (from RefSeq NR_130325.1) ENSMUST00000116930.1 ENSMUST00000116930.2 NR_130325 uc056yue.1 uc056yue.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yue.1 uc056yue.2 
ENSMUST00000116932.3 Gm24907 ENSMUST00000116932.3 Gm24907 (from geneSymbol) ENSMUST00000116932.1 ENSMUST00000116932.2 LF202275 uc292rda.1 uc292rda.2 uc292rda.1 uc292rda.2 
ENSMUST00000116936.3 Mir1187 ENSMUST00000116936.3 microRNA 1187 (from RefSeq NR_035415.1) ENSMUST00000116936.1 ENSMUST00000116936.2 NR_035415 uc012dxs.1 uc012dxs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610089.1 [ECO:0000345] ##Evidence-Data-END## uc012dxs.1 uc012dxs.2 
ENSMUST00000116944.3 Mir669h ENSMUST00000116944.3 microRNA 669h (from RefSeq NR_035418.1) ENSMUST00000116944.1 ENSMUST00000116944.2 NR_035418 uc056zkz.1 uc056zkz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610092.1 [ECO:0000345] ##Evidence-Data-END## uc056zkz.1 uc056zkz.2 
ENSMUST00000116945.4 Gm22031 ENSMUST00000116945.4 Gm22031 (from geneSymbol) ENSMUST00000116945.1 ENSMUST00000116945.2 ENSMUST00000116945.3 uc288wsb.1 uc288wsb.2 uc288wsb.1 uc288wsb.2 
ENSMUST00000116957.3 Gm23839 ENSMUST00000116957.3 Gm23839 (from geneSymbol) ENSMUST00000116957.1 ENSMUST00000116957.2 uc287pyu.1 uc287pyu.2 uc287pyu.1 uc287pyu.2 
ENSMUST00000116960.3 Snord110 ENSMUST00000116960.3 small nucleolar RNA, C/D box 110 (from RefSeq NR_028547.1) ENSMUST00000116960.1 ENSMUST00000116960.2 NR_028547 uc012cea.1 uc012cea.2 uc012cea.3 uc012cea.1 uc012cea.2 uc012cea.3 
ENSMUST00000116965.3 Snord99 ENSMUST00000116965.3 small nucleolar RNA, C/D box 99 (from RefSeq NR_028537.1) ENSMUST00000116965.1 ENSMUST00000116965.2 NR_028537 uc290qko.1 uc290qko.2 uc290qko.1 uc290qko.2 
ENSMUST00000116966.3 Gm22152 ENSMUST00000116966.3 Gm22152 (from geneSymbol) ENSMUST00000116966.1 ENSMUST00000116966.2 uc288eku.1 uc288eku.2 uc288eku.1 uc288eku.2 
ENSMUST00000116972.3 Gm22676 ENSMUST00000116972.3 Gm22676 (from geneSymbol) ENSMUST00000116972.1 ENSMUST00000116972.2 LF193483 uc289zht.1 uc289zht.2 uc289zht.1 uc289zht.2 
ENSMUST00000116976.3 Mir1192 ENSMUST00000116976.3 microRNA 1192 (from RefSeq NR_035423.1) ENSMUST00000116976.1 ENSMUST00000116976.2 NR_035423 uc012bjn.1 uc012bjn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012bjn.1 uc012bjn.2 
ENSMUST00000116995.3 Mir1198 ENSMUST00000116995.3 microRNA 1198 (from RefSeq NR_035430.1) ENSMUST00000116995.1 ENSMUST00000116995.2 NR_035430 uc057aqq.1 uc057aqq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057aqq.1 uc057aqq.2 
ENSMUST00000117003.3 Mir669e ENSMUST00000117003.3 microRNA 669e (from RefSeq NR_035426.1) ENSMUST00000117003.1 ENSMUST00000117003.2 NR_035426 uc056zjk.1 uc056zjk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zjk.1 uc056zjk.2 
ENSMUST00000117007.3 Mir669i ENSMUST00000117007.3 microRNA 669i (from RefSeq NR_035417.1) ENSMUST00000117007.1 ENSMUST00000117007.2 NR_035417 uc012bqr.1 uc012bqr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610091.1 [ECO:0000345] ##Evidence-Data-END## uc012bqr.1 uc012bqr.2 
ENSMUST00000117012.2 Mir1b ENSMUST00000117012.2 microRNA 1b (from RefSeq NR_035413.1) ENSMUST00000117012.1 NR_035413 uc012azg.1 uc012azg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM610088.1 [ECO:0000345] ##Evidence-Data-END## uc012azg.1 uc012azg.2 
ENSMUST00000117015.3 Mir1199 ENSMUST00000117015.3 microRNA 1199 (from RefSeq NR_035431.1) ENSMUST00000117015.1 ENSMUST00000117015.2 NR_035431 uc012ggx.1 uc012ggx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610103.1 [ECO:0000345] ##Evidence-Data-END## uc012ggx.1 uc012ggx.2 
ENSMUST00000117019.3 Mir1224 ENSMUST00000117019.3 microRNA 1224 (from RefSeq NR_035407.1) ENSMUST00000117019.1 ENSMUST00000117019.2 NR_035407 uc012acw.1 uc012acw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609640.1 [ECO:0000345] ##Evidence-Data-END## uc012acw.1 uc012acw.2 
ENSMUST00000117023.3 Gm23336 ENSMUST00000117023.3 Gm23336 (from geneSymbol) ENSMUST00000117023.1 ENSMUST00000117023.2 uc290itb.1 uc290itb.2 uc290itb.1 uc290itb.2 
ENSMUST00000117033.3 Gm23991 ENSMUST00000117033.3 Gm23991 (from geneSymbol) ENSMUST00000117033.1 ENSMUST00000117033.2 uc291pds.1 uc291pds.2 uc291pds.1 uc291pds.2 
ENSMUST00000117037.3 Mir1197 ENSMUST00000117037.3 microRNA 1197 (from RefSeq NR_035429.1) ENSMUST00000117037.1 ENSMUST00000117037.2 NR_035429 uc011ytc.1 uc011ytc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610101.1 [ECO:0000345] ##Evidence-Data-END## uc011ytc.1 uc011ytc.2 
ENSMUST00000117039.3 Gm23987 ENSMUST00000117039.3 Gm23987 (from geneSymbol) ENSMUST00000117039.1 ENSMUST00000117039.2 uc288ynp.1 uc288ynp.2 uc288ynp.1 uc288ynp.2 
ENSMUST00000117085.2 Abhd17c ENSMUST00000117085.2 abhydrolase domain containing 17C (from RefSeq NM_133722.2) AB17C_MOUSE Abhd17c ENSMUST00000117085.1 NM_133722 Q8VCV1 uc009ied.1 uc009ied.2 uc009ied.3 Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; EC=3.1.2.22; Evidence=; Recycling endosome membrane ; Lipid-anchor ; Cytoplasmic side Cell projection, dendritic spine Postsynaptic density membrane Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. protein depalmitoylation endosome plasma membrane palmitoyl-(protein) hydrolase activity postsynaptic density membrane hydrolase activity protein palmitoylation cell junction cell projection dendritic spine synapse postsynaptic membrane recycling endosome membrane glutamatergic synapse negative regulation of protein localization to microtubule positive regulation of protein localization to endosome uc009ied.1 uc009ied.2 uc009ied.3 
ENSMUST00000117100.4 Slc45a2 ENSMUST00000117100.4 solute carrier family 45, member 2 (from RefSeq NM_053077.3) D3YWT7 ENSMUST00000117100.1 ENSMUST00000117100.2 ENSMUST00000117100.3 Matp Mstp1 NM_053077 Q541S3 Q541S3_MOUSE Slc45a2 uc007vgx.1 uc007vgx.2 Membrane ; Multi- pass membrane protein Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. membrane integral component of membrane uc007vgx.1 uc007vgx.2 
ENSMUST00000117102.4 Fzd10 ENSMUST00000117102.4 frizzled class receptor 10 (from RefSeq NM_175284.3) ENSMUST00000117102.1 ENSMUST00000117102.2 ENSMUST00000117102.3 FZD10_MOUSE Fz10 NM_175284 Q8BKG4 uc008zsh.1 uc008zsh.2 uc008zsh.3 Receptor for Wnt proteins (PubMed:15923619). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Interacts with MYOC (By similarity). Interacts with WNT7B (PubMed:15923619). Cell membrane ; Multi-pass membrane protein Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. The FZ domain is involved in binding with Wnt ligands. Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. Belongs to the G-protein coupled receptor Fz/Smo family. transmembrane signaling receptor activity G-protein coupled receptor activity nucleoplasm cytoplasm plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway multicellular organism development cell surface membrane integral component of membrane Wnt signaling pathway Wnt-protein binding regulation of actin cytoskeleton organization negative regulation of GTPase activity non-canonical Wnt signaling pathway non-canonical Wnt signaling pathway via JNK cascade Wnt-activated receptor activity positive regulation of JUN kinase activity positive regulation of GTPase activity canonical Wnt signaling pathway uc008zsh.1 uc008zsh.2 uc008zsh.3 
ENSMUST00000117136.2 Mzt2 ENSMUST00000117136.2 mitotic spindle organizing protein 2, transcript variant 1 (from RefSeq NM_001359003.1) ENSMUST00000117136.1 Fam128b MZT2_MOUSE Mozart2 NM_001359003 Q9CQ25 uc007yhw.1 uc007yhw.2 uc007yhw.3 Part of the gamma-tubulin complex. Interacts with TUBG1. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Belongs to the MOZART2 family. molecular_function nucleoplasm cytoplasm centrosome microtubule organizing center spindle cytosol cytoskeleton biological_process gamma-tubulin ring complex uc007yhw.1 uc007yhw.2 uc007yhw.3 
ENSMUST00000117137.8 Mep1a ENSMUST00000117137.8 Reaction=Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.; EC=3.4.24.18; Evidence=; (from UniProt P28825) B0V2P9 BC015258 ENSMUST00000117137.1 ENSMUST00000117137.2 ENSMUST00000117137.3 ENSMUST00000117137.4 ENSMUST00000117137.5 ENSMUST00000117137.6 ENSMUST00000117137.7 MEP1A_MOUSE P28825 Q91WH9 uc008cpc.1 uc008cpc.2 uc008cpc.3 Reaction=Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.; EC=3.4.24.18; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. Inhibited by metal ion chelators EDTA and 1,10- phenanthroline, bradykinin analogs, cysteine, CONA65, and several hydroxamate compounds, particularly tyrosine hydroxamate. Not inhibited by 3,4-dichloroisocourmarin, soybean trypsin inhibitor, or the cysteine proteinase inhibitors iodoacetic acid and E-64. Kinetic parameters: KM=29.6 uM for GRP KM=67.2 uM for PTH 12-34 KM=111 uM for secretin KM=30.6 uM for substance P KM=156 uM for LHRH KM=22.3 uM for alpha-MSH KM=101 uM for bradykinin KM=290 uM for Arg-Pro-Pro-Gly-Npa-Ser-Pro-Phe-Arg KM=331 uM for Arg-Pro-Pro-Gly-Npa-Ala-Pro-Phe-Arg KM=174 uM for Arg-Pro-Pro-Gly-Npa-Arg-Pro-Phe-Arg KM=226 uM for Arg-Pro-Pro-Gly-Npa-Phe-Pro-Phe-Arg KM=182 uM for Arg-Pro-Pro-Gly-Npa-Lys-Pro-Phe-Arg KM=339 uM for Arg-Pro-Pro-Gly-Npa-Glu-Pro-Phe-Arg KM=366 uM for 2ABz-Arg-Pro-Gly-Phe-Ser-Pro-Npa-Arg KM=296 uM for 2ABz-Arg-Pro-Ile-Phe-Ser-Pro-Npa-Arg KM=183 uM for 2ABz-Arg-Hyp-Gly-Phe-Ser-Pro-Npa-Arg KM=220 uM for 2ABz-Arg-Gly-Pro-Phe-Ser-Pro-Npa-Arg KM=1380 uM for 2ABz-Arg-Pro-Gly-Ala-Ser-Pro-Npa-Arg KM=1220 uM for 2ABz-Arg-Pro-Gly-Glu-Ser-Pro-Npa-Arg KM=402 uM for 2ABz-Arg-Pro-Gly-Lys-Ser-Pro-Npa-Arg KM=2460 uM for 2ABz-Arg-Pro-Gly-Leu-Ser-Pro-Npa-Arg Temperature dependence: The half-life at 58 degrees Celsius is 50 minutes. Homotetramer consisting of disulfide-linked alpha subunits, homooligomer consisting of disulfide-linked alpha subunit homodimers, or heterotetramer of two alpha and two beta subunits formed by non- covalent association of two disulfide-linked heterodimers. Genetic factors determine which oligomer(s) will be formed (strain-specific). Interacts with MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity. Membrane; Single-pass type I membrane protein. Kidney, intestinal brush borders and salivary ducts. N-glycosylated; contains GlcNAc, galactose, mannose and a small amount of fucose. Sequence=AAA75354.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH15258.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; metalloendopeptidase activity proteolysis peptidase activity metallopeptidase activity zinc ion binding membrane integral component of membrane hydrolase activity meprin A complex metal ion binding uc008cpc.1 uc008cpc.2 uc008cpc.3 
ENSMUST00000117141.4 Or4b1b ENSMUST00000117141.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGN8) ENSMUST00000117141.1 ENSMUST00000117141.2 ENSMUST00000117141.3 Olfr1272 Or4b1b Q8VGN8 Q8VGN8_MOUSE uc289yfn.1 uc289yfn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yfn.1 uc289yfn.2 
ENSMUST00000117146.9 Ube2w ENSMUST00000117146.9 ubiquitin-conjugating enzyme E2W (putative), transcript variant 1 (from RefSeq NM_025773.4) ENSMUST00000117146.1 ENSMUST00000117146.2 ENSMUST00000117146.3 ENSMUST00000117146.4 ENSMUST00000117146.5 ENSMUST00000117146.6 ENSMUST00000117146.7 ENSMUST00000117146.8 NM_025773 Q8BVJ8 Q8VDW4 Q9D5H3 UBE2W_MOUSE uc007ajt.1 uc007ajt.2 uc007ajt.3 uc007ajt.4 uc007ajt.5 uc007ajt.6 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini (PubMed:21855799, PubMed:21229326). Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3 (PubMed:21855799). After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:21229326). In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate (By similarity). Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence= Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].; EC=2.3.2.25; Evidence=; Protein modification; protein ubiquitination. Homodimer (By similarity). Interacts with FANCL. Interacts with STUB1/CHIP. Nucleus Note=In the nucleus, colocalizes with FANCL. Autoubiquitinated at Met-1. Belongs to the ubiquitin-conjugating enzyme family. Sequence=BAC37094.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding ubiquitin-protein transferase activity protein binding ATP binding nucleus DNA repair protein monoubiquitination misfolded or incompletely synthesized protein catabolic process cellular response to DNA damage stimulus protein ubiquitination transferase activity ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin conjugating enzyme activity protein K11-linked ubiquitination cellular response to misfolded protein uc007ajt.1 uc007ajt.2 uc007ajt.3 uc007ajt.4 uc007ajt.5 uc007ajt.6 
ENSMUST00000117150.8 Phtf1 ENSMUST00000117150.8 putative homeodomain transcription factor 1, transcript variant 2 (from RefSeq NM_001163467.1) ENSMUST00000117150.1 ENSMUST00000117150.2 ENSMUST00000117150.3 ENSMUST00000117150.4 ENSMUST00000117150.5 ENSMUST00000117150.6 ENSMUST00000117150.7 NM_001163467 PHTF1_MOUSE Phtf Phtf1 Q9CS51 Q9CSB9 Q9QZ09 Q9QZ14 uc012cvg.1 uc012cvg.2 uc012cvg.3 Interacts with FEM1B. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein Widely expressed with highest levels in testis. The PHTF domain was initially defined as an atypical homeodomain, suggesting that this protein could act as a transcription regulator (By similarity). However, the protein is not found in the nucleus and mainly localizes in the endoplasmic reticulum membrane, suggesting that it does not act as a transcription factor (By similarity). DNA binding nucleus endoplasmic reticulum cis-Golgi network biological_process uc012cvg.1 uc012cvg.2 uc012cvg.3 
ENSMUST00000117160.2 Cdh13 ENSMUST00000117160.2 cadherin 13 (from RefSeq NM_019707.5) CAD13_MOUSE ENSMUST00000117160.1 NM_019707 Q8BG11 Q9WTR5 uc009npl.1 uc009npl.2 uc009npl.3 uc009npl.4 This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is highly expressed in the vasculature including endothelial cells, smooth muscle cells and pericytes, where the encoded protein binds to adiponectin and has been implicated in the modulation of angiogenesis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK134649.1, SRR1660811.189232.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1- EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape. Cell membrane ; Lipid-anchor, GPI- anchor Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. mitotic cell cycle cell morphogenesis positive regulation of endothelial cell proliferation positive regulation of cell-matrix adhesion sprouting angiogenesis calcium ion binding protein binding extracellular space cytoplasm plasma membrane caveola cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules negative regulation of cell adhesion Rho protein signal transduction cytoskeletal protein binding negative regulation of cell proliferation external side of plasma membrane cell surface response to organic substance membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex Rac protein signal transduction lamellipodium assembly regulation of endocytosis low-density lipoprotein particle binding positive regulation of cell migration anchored component of membrane adherens junction organization regulation of epidermal growth factor receptor signaling pathway protein homodimerization activity neuron projection endothelial cell migration keratinocyte proliferation cell-cell adhesion mediated by cadherin synapse cadherin binding positive regulation of transcription from RNA polymerase II promoter metal ion binding perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation positive regulation of calcium-mediated signaling positive regulation of positive chemotaxis localization within membrane low-density lipoprotein particle mediated signaling adiponectin binding lipoprotein particle binding cell-cell adhesion GABA-ergic synapse uc009npl.1 uc009npl.2 uc009npl.3 uc009npl.4 
ENSMUST00000117167.2 S100a9 ENSMUST00000117167.2 S100 calcium binding protein A9 (calgranulin B), transcript variant 2 (from RefSeq NM_009114.3) ENSMUST00000117167.1 NM_009114 Q3UP42 Q3UP42_MOUSE S100a9 uc008qde.1 uc008qde.2 uc008qde.3 uc008qde.4 Cell membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton Membrane ; Peripheral membrane protein Secreted Belongs to the S-100 family. calcium ion binding microtubule binding zinc ion binding Toll-like receptor 4 binding innate immune response metal ion binding arachidonic acid binding regulation of inflammatory response RAGE receptor binding uc008qde.1 uc008qde.2 uc008qde.3 uc008qde.4 
ENSMUST00000117173.8 Clec4a3 ENSMUST00000117173.8 C-type lectin domain family 4, member a3, transcript variant 2 (from RefSeq NM_001204241.1) Clec4a3 Dcir3 ENSMUST00000117173.1 ENSMUST00000117173.2 ENSMUST00000117173.3 ENSMUST00000117173.4 ENSMUST00000117173.5 ENSMUST00000117173.6 ENSMUST00000117173.7 NM_001204241 Q5YIR7 Q8JZX6 Q8JZX6_MOUSE uc009dpv.1 uc009dpv.2 uc009dpv.3 uc009dpv.4 molecular_function aspartic-type endopeptidase activity cellular_component proteolysis biological_process membrane integral component of membrane carbohydrate binding uc009dpv.1 uc009dpv.2 uc009dpv.3 uc009dpv.4 
ENSMUST00000117179.9 Fgfr1 ENSMUST00000117179.9 fibroblast growth factor receptor 1, transcript variant 2 (from RefSeq NM_001079908.3) ENSMUST00000117179.1 ENSMUST00000117179.2 ENSMUST00000117179.3 ENSMUST00000117179.4 ENSMUST00000117179.5 ENSMUST00000117179.6 ENSMUST00000117179.7 ENSMUST00000117179.8 Fgfr1 NM_001079908 Q8CIM9 Q8CIM9_MOUSE uc009lfz.1 uc009lfz.2 uc009lfz.3 uc009lfz.4 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence= Cell membrane ; Single-pass type I membrane protein Cytoplasm, cytosol Cytoplasmic vesicle Membrane ; Single-pass type I membrane protein Nucleus Vesicle Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor-activated receptor activity ATP binding protein phosphorylation positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation uc009lfz.1 uc009lfz.2 uc009lfz.3 uc009lfz.4 
ENSMUST00000117191.3 Gm16140 ENSMUST00000117191.3 Gm16140 (from geneSymbol) BC086661 ENSMUST00000117191.1 ENSMUST00000117191.2 uc287wui.1 uc287wui.2 uc287wui.3 uc287wui.1 uc287wui.2 uc287wui.3 
ENSMUST00000117193.8 Oas1c ENSMUST00000117193.8 2'-5' oligoadenylate synthetase 1C (from RefSeq NM_033541.4) ENSMUST00000117193.1 ENSMUST00000117193.2 ENSMUST00000117193.3 ENSMUST00000117193.4 ENSMUST00000117193.5 ENSMUST00000117193.6 ENSMUST00000117193.7 NM_033541 OAS1C_MOUSE Oas1c Oasl5 Q924S2 uc008zid.1 uc008zid.2 uc008zid.3 Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Expressed at highest level in brain with lesser amounts in spleen, kidney, stomach, liver, intestine, ovary, skin and testis. Not detected in lung, thymus, heart and uterus. Expressed in embryonic stem cells and embryonic fibroblasts (PubMed:11418248). Detected 1 week after birth in developing ovary (PubMed:27663720). By interferon (IFN) and polyinosinic:polycytidylic acid (poly I:C). Belongs to the 2-5A synthase family. RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm cytosol immune response transferase activity negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity 2'-5'-oligoadenylate synthetase activity uc008zid.1 uc008zid.2 uc008zid.3 
ENSMUST00000117200.8 Robo2 ENSMUST00000117200.8 roundabout guidance receptor 2, transcript variant 7 (from RefSeq NM_001415036.1) E9Q6A0 E9Q6A0_MOUSE ENSMUST00000117200.1 ENSMUST00000117200.2 ENSMUST00000117200.3 ENSMUST00000117200.4 ENSMUST00000117200.5 ENSMUST00000117200.6 ENSMUST00000117200.7 NM_001415036 Robo2 uc289fmc.1 uc289fmc.2 membrane integral component of membrane uc289fmc.1 uc289fmc.2 
ENSMUST00000117211.3 Or8h10 ENSMUST00000117211.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFM1) ENSMUST00000117211.1 ENSMUST00000117211.2 Olfr1100 Or8h10 Q8VFM1 Q8VFM1_MOUSE uc008kne.1 uc008kne.2 uc008kne.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kne.1 uc008kne.2 uc008kne.3 
ENSMUST00000117222.2 Gemin7 ENSMUST00000117222.2 The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre- mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). (from UniProt Q9CWY4) AK010303 ENSMUST00000117222.1 GEMI7_MOUSE Q9CWY4 uc033ixb.1 uc033ixb.2 uc033ixb.3 The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre- mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP (By similarity). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG (By similarity). Interacts with GEMIN6; the interaction is direct (By similarity). Interacts with STRAP/UNRIP; the interaction is direct (By similarity). Interacts with GEMIN8; the interaction is direct (By similarity). Interacts with SNRPB, SNRPD2, SNRPD3 and SNRPE; the interaction is direct (By similarity). Nucleus, nucleoplasm Nucleus, gem Cytoplasm Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm (By similarity). Belongs to the gemin-7 family. spliceosomal snRNP assembly protein binding nucleus nucleoplasm cytoplasm cytosol mRNA processing RNA splicing nuclear body SMN complex SMN-Sm protein complex Gemini of coiled bodies uc033ixb.1 uc033ixb.2 uc033ixb.3 
ENSMUST00000117236.8 Dcaf11 ENSMUST00000117236.8 DDB1 and CUL4 associated factor 11, transcript variant 2 (from RefSeq NM_133734.3) D14Ucla1 DCA11_MOUSE ENSMUST00000117236.1 ENSMUST00000117236.2 ENSMUST00000117236.3 ENSMUST00000117236.4 ENSMUST00000117236.5 ENSMUST00000117236.6 ENSMUST00000117236.7 NM_133734 Q3U836 Q8JZV8 Q91VU6 Wdr23 uc007tyz.1 uc007tyz.2 uc007tyz.3 uc007tyz.4 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Protein modification; protein ubiquitination. Interacts with DDB1 and CUL4A. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VU6-1; Sequence=Displayed; Name=2; IsoId=Q91VU6-2; Sequence=VSP_008425, VSP_008426; molecular_function nucleoplasm protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process Cul4-RING E3 ubiquitin ligase complex uc007tyz.1 uc007tyz.2 uc007tyz.3 uc007tyz.4 
ENSMUST00000117242.8 Golim4 ENSMUST00000117242.8 golgi integral membrane protein 4, transcript variant 1 (from RefSeq NM_001291069.1) D3YVW2 D3YVW2_MOUSE ENSMUST00000117242.1 ENSMUST00000117242.2 ENSMUST00000117242.3 ENSMUST00000117242.4 ENSMUST00000117242.5 ENSMUST00000117242.6 ENSMUST00000117242.7 Golim4 NM_001291069 uc008png.1 uc008png.2 uc008png.3 Golgi membrane Golgi apparatus membrane integral component of membrane uc008png.1 uc008png.2 uc008png.3 
ENSMUST00000117245.2 Trp53bp2 ENSMUST00000117245.2 transformation related protein 53 binding protein 2 (from RefSeq NM_173378.3) E9QJU8 E9QJU8_MOUSE ENSMUST00000117245.1 NM_173378 Trp53bp2 uc007dyc.1 uc007dyc.2 uc007dyc.3 Nucleus p53 binding nucleus cytoplasm cytosol cell junction identical protein binding perinuclear region of cytoplasm NF-kappaB binding intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of execution phase of apoptosis positive regulation of neuron death uc007dyc.1 uc007dyc.2 uc007dyc.3 
ENSMUST00000117271.3 Atg4a-ps ENSMUST00000117271.3 Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. (from UniProt A0A0G2JFS9) A0A0G2JFS9 A0A0G2JFS9_MOUSE Atg4a-ps ENSMUST00000117271.1 ENSMUST00000117271.2 LF194124 uc029unx.1 uc029unx.2 uc029unx.3 Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. Reaction=[protein]-C-terminal L-amino acid-glycyl- phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid- glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:67548, Rhea:RHEA-COMP:17323, Rhea:RHEA-COMP:17324, ChEBI:CHEBI:15377, ChEBI:CHEBI:64612, ChEBI:CHEBI:172940, ChEBI:CHEBI:172941; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67549; Evidence=; Cytoplasm Belongs to the peptidase C54 family. cysteine-type endopeptidase activity cytoplasm proteolysis autophagy peptidase activity cysteine-type peptidase activity protein transport hydrolase activity uc029unx.1 uc029unx.2 uc029unx.3 
ENSMUST00000117276.11 Slc39a3 ENSMUST00000117276.11 Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:14525987, PubMed:15634741, PubMed:35169020). Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus (PubMed:35169020). Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen (PubMed:19458277). (from UniProt Q99K24) AK087519 ENSMUST00000117276.1 ENSMUST00000117276.10 ENSMUST00000117276.2 ENSMUST00000117276.3 ENSMUST00000117276.4 ENSMUST00000117276.5 ENSMUST00000117276.6 ENSMUST00000117276.7 ENSMUST00000117276.8 ENSMUST00000117276.9 Q99K24 S39A3_MOUSE Zip3 uc007gfr.1 uc007gfr.2 uc007gfr.3 Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:14525987, PubMed:15634741, PubMed:35169020). Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus (PubMed:35169020). Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen (PubMed:19458277). Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29352; Evidence=; Kinetic parameters: KM=1.6 uM for Zn(2+) ; Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Note=Localized primarily at the cell surface but also found in a perinuclear compartment in HC11 cells (PubMed:15634741). In mammary epithelial cell, localized primary to the apical membrane (PubMed:19458277). Highly expressed in the testes (PubMed:14525987). Highly expressed in dentate gyrus granule cells of the hippocampus (PubMed:35169020). Expressed in the mammary gland (PubMed:19458277). Expressed very early during development of the mouse embryo. Expression is higher in testes, ovary, and the developing nervous system relative to other tissues. Knockout mice are viable and fertile and under normal growth conditions exhibit no obvious phenotypic abnormalities, and are only slightly more susceptible to the effects of dietary zinc deficiency. Belongs to the ZIP transporter (TC 2.A.5) family. cell morphogenesis in utero embryonic development zinc ion transmembrane transporter activity plasma membrane ion transport zinc II ion transport membrane integral component of membrane metal ion transport T cell homeostasis metal ion transmembrane transporter activity embryonic cranial skeleton morphogenesis transmembrane transport limb development zinc II ion transmembrane transport uc007gfr.1 uc007gfr.2 uc007gfr.3 
ENSMUST00000117280.8 Smc2 ENSMUST00000117280.8 structural maintenance of chromosomes 2, transcript variant 2 (from RefSeq NM_008017.4) Cape ENSMUST00000117280.1 ENSMUST00000117280.2 ENSMUST00000117280.3 ENSMUST00000117280.4 ENSMUST00000117280.5 ENSMUST00000117280.6 ENSMUST00000117280.7 Fin16 NM_008017 Q52KE9 Q61076 Q8CG48 Q9CS17 Q9CSD8 SMC2_MOUSE Smc2l1 uc008swk.1 uc008swk.2 uc008swk.3 uc008swk.4 The protein encoded by this gene is a component of both condensin I and condensin II complexes, and forms a heterodimer with structural maintenance of chromosome 4 (Smc4). This heterodimer is the catalytic subunit for both condensin complexes, and is involved in several processes, including chromosome condensation during mitosis and meiosis, cohesin removal during mitosis and meiosis, and single-strand break (SSB) repair. Reduced expression of this gene results in chromosome segregation defects during mitosis and meiosis, with a more severe defect observed in embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG (By similarity). Q8CG48; Q8BH43: Wasf2; NbExp=4; IntAct=EBI-643436, EBI-643162; Nucleus Cytoplasm Chromosome Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase (By similarity). The SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer. Belongs to the SMC family. SMC2 subfamily. Sequence=AAB08867.1; Type=Erroneous initiation; Evidence=; single strand break repair nucleotide binding nuclear chromosome condensed chromosome condensin complex single-stranded DNA binding protein binding ATP binding nucleus chromosome nucleolus cytoplasm cell cycle mitotic chromosome condensation meiotic chromosome condensation chromosome condensation meiotic chromosome segregation protein heterodimerization activity chromosome organization cell division kinetochore organization uc008swk.1 uc008swk.2 uc008swk.3 uc008swk.4 
ENSMUST00000117299.10 Selenoh ENSMUST00000117299.10 selenoprotein H, transcript variant 1 (from RefSeq NM_001033166.3) ENSMUST00000117299.1 ENSMUST00000117299.2 ENSMUST00000117299.3 ENSMUST00000117299.4 ENSMUST00000117299.5 ENSMUST00000117299.6 ENSMUST00000117299.7 ENSMUST00000117299.8 ENSMUST00000117299.9 NM_001033166 Q3UQA7 Q7TNQ0 SELH_MOUSE Selenoh uc008kiw.1 uc008kiw.2 uc008kiw.3 uc008kiw.4 This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]. May be involved in a redox-related process. Belongs to the SelWTH family. cytoplasm Golgi apparatus uc008kiw.1 uc008kiw.2 uc008kiw.3 uc008kiw.4 
ENSMUST00000117301.8 Ddr1 ENSMUST00000117301.8 discoidin domain receptor family, member 1, transcript variant 1 (from RefSeq NM_007584.3) Cak DDR1_MOUSE ENSMUST00000117301.1 ENSMUST00000117301.2 ENSMUST00000117301.3 ENSMUST00000117301.4 ENSMUST00000117301.5 ENSMUST00000117301.6 ENSMUST00000117301.7 Eddr1 Mpk6 NM_007584 Q03146 uc008cim.1 uc008cim.2 Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2 (By similarity). Cell membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CAK I; IsoId=Q03146-1; Sequence=Displayed; Name=2; Synonyms=CAK II; IsoId=Q03146-2; Sequence=VSP_002954; Detected in the cochlea and the organ of Corti in the inner ear. Isoform 1 is predominant and is expressed in developing embryo and adult brain. Isoform 2 is expressed in various epithelial cells. Autophosphorylated in response to fibrillar collagen binding. Mice are born at the expected Mendelian rate, but female mice are dwarfs and most of them are unable to bear offspring, due to defects in blastocyte implantation in the uterus. About one fifth can bear offspring, but for these the mammary gland fails to undergo proper differentiation during pregnancy, with hyperproliferation and abnormal branching of the mammary ducts, leading to a lactation defect. In addition, mice exhibit hearing loss, due to alterations of the inner ear. Mice display poor calcification of the fibula. They also exhibit defects in the structure of the slit diaphragm in kidney glomeruli, leading to proteinuria, but do not show overt signs of kidney dysfunction. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. nucleotide binding regulation of cell growth regulation of cell-matrix adhesion protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity collagen binding ATP binding cytoplasm plasma membrane integral component of plasma membrane brush border protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway female pregnancy embryo implantation lactation negative regulation of cell proliferation regulation of extracellular matrix disassembly smooth muscle cell migration membrane integral component of membrane kinase activity phosphorylation basolateral plasma membrane transferase activity peptidyl-tyrosine phosphorylation protein tyrosine kinase collagen receptor activity collagen-activated tyrosine kinase receptor signaling pathway peptidyl-tyrosine autophosphorylation receptor complex ear development wound healing, spreading of cells protein autophosphorylation metal ion binding branching involved in mammary gland duct morphogenesis mammary gland alveolus development smooth muscle cell-matrix adhesion axon development neuron projection extension uc008cim.1 uc008cim.2 
ENSMUST00000117338.8 Eml2 ENSMUST00000117338.8 echinoderm microtubule associated protein like 2, transcript variant 3 (from RefSeq NM_001347582.2) E9QK48 EMAL2_MOUSE ENSMUST00000117338.1 ENSMUST00000117338.2 ENSMUST00000117338.3 ENSMUST00000117338.4 ENSMUST00000117338.5 ENSMUST00000117338.6 ENSMUST00000117338.7 NM_001347582 Q7TNG5 Q9DAS8 uc057ltc.1 uc057ltc.2 uc057ltc.3 Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules. Interacts with GRID2 and may also interact with GRID1. Interacts with EML3. Binds unpolymerized tubulins via its WD repeat region. Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, spindle Note=Colocalizes with the microtubule cytoskeleton. Colocalizes with the mitotic spindle. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7TNG5-1; Sequence=Displayed; Name=2; IsoId=Q7TNG5-2; Sequence=VSP_024480; Name=3; IsoId=Q7TNG5-3; Sequence=VSP_061498; Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain (By similarity). Belongs to the WD repeat EMAP family. Sequence=BAB24122.1; Type=Frameshift; Evidence=; microtubule cytoskeleton organization receptor binding cytoplasm spindle cytoskeleton microtubule microtubule binding protein C-terminus binding regulation of microtubule nucleation tubulin binding negative regulation of microtubule polymerization mitotic spindle uc057ltc.1 uc057ltc.2 uc057ltc.3 
ENSMUST00000117346.2 Best1 ENSMUST00000117346.2 bestrophin 1 (from RefSeq NM_011913.2) B2RSY6 BEST1_MOUSE Bmd1 ENSMUST00000117346.1 NM_011913 O88870 Q6H1V0 Vmd2 uc008gou.1 uc008gou.2 uc008gou.3 uc008gou.4 Forms calcium-sensitive chloride channels. Permeable to bicarbonate (By similarity). Tetramer or pentamers. May interact with PPP2CB and PPP2R1B (By similarity). Cell membrane; Multi-pass membrane protein. Basolateral cell membrane Phosphorylated by PP2A. Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily. chloride channel activity plasma membrane ion transport chloride transport membrane integral component of membrane basolateral plasma membrane transepithelial chloride transport chloride channel complex identical protein binding detection of light stimulus involved in visual perception regulation of calcium ion transport chloride transmembrane transport uc008gou.1 uc008gou.2 uc008gou.3 uc008gou.4 
ENSMUST00000117349.8 Or1e20-ps1 ENSMUST00000117349.8 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGT2) ENSMUST00000117349.1 ENSMUST00000117349.2 ENSMUST00000117349.3 ENSMUST00000117349.4 ENSMUST00000117349.5 ENSMUST00000117349.6 ENSMUST00000117349.7 Olfr378 Or1e19 Q8VGT2 Q8VGT2_MOUSE uc287zzj.1 uc287zzj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287zzj.1 uc287zzj.2 
ENSMUST00000117363.9 Lsg1 ENSMUST00000117363.9 large 60S subunit nuclear export GTPase 1, transcript variant 9 (from RefSeq NR_184414.1) D16Bwg1547e ENSMUST00000117363.1 ENSMUST00000117363.2 ENSMUST00000117363.3 ENSMUST00000117363.4 ENSMUST00000117363.5 ENSMUST00000117363.6 ENSMUST00000117363.7 ENSMUST00000117363.8 LSG1_MOUSE NR_184414 Q3UM18 Q68ED9 Q80V36 uc007ywv.1 uc007ywv.2 uc007ywv.3 GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity). Cytoplasm Nucleus Endoplasmic reticulum Note=Shuttles between the Cajal bodies in the nucleus and the endoplasmic reticulum. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UM18-1; Sequence=Displayed; Name=2; IsoId=Q3UM18-2; Sequence=VSP_032275; In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern. Belongs to the TRAFAC class YlqF/YawG GTPase family. LSG1 subfamily. nucleotide binding GTPase activity GTP binding nucleus cytoplasm endoplasmic reticulum cytosol Cajal body protein transport nuclear body hydrolase activity nuclear export uc007ywv.1 uc007ywv.2 uc007ywv.3 
ENSMUST00000117377.8 Spock3 ENSMUST00000117377.8 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3, transcript variant 4 (from RefSeq NM_001361918.1) ENSMUST00000117377.1 ENSMUST00000117377.2 ENSMUST00000117377.3 ENSMUST00000117377.4 ENSMUST00000117377.5 ENSMUST00000117377.6 ENSMUST00000117377.7 NM_001361918 Q8BKV0 Q9ER59 TICN3_MOUSE uc009lur.1 uc009lur.2 uc009lur.3 uc009lur.4 May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion (By similarity). Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BKV0-1; Sequence=Displayed; Name=2; IsoId=Q8BKV0-2; Sequence=VSP_013633; Expressed in brain. Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides. enzyme inhibitor activity calcium ion binding collagen binding glycosaminoglycan binding extracellular region extracellular space metalloendopeptidase inhibitor activity negative regulation of peptidase activity negative regulation of endopeptidase activity peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan peptidase inhibitor activity extracellular matrix extracellular matrix binding uc009lur.1 uc009lur.2 uc009lur.3 uc009lur.4 
ENSMUST00000117386.2 Synpo2l ENSMUST00000117386.2 synaptopodin 2-like, transcript variant 1 (from RefSeq NM_001310431.1) B2RQK7 B2RQK7_MOUSE ENSMUST00000117386.1 NM_001310431 Synpo2l uc011zgs.1 uc011zgs.2 uc011zgs.3 uc011zgs.4 Belongs to the synaptopodin family. nucleus nucleoplasm cytosol nuclear speck cell junction uc011zgs.1 uc011zgs.2 uc011zgs.3 uc011zgs.4 
ENSMUST00000117388.8 Lnx1 ENSMUST00000117388.8 ligand of numb-protein X 1, transcript variant 1 (from RefSeq NM_001159577.1) ENSMUST00000117388.1 ENSMUST00000117388.2 ENSMUST00000117388.3 ENSMUST00000117388.4 ENSMUST00000117388.5 ENSMUST00000117388.6 ENSMUST00000117388.7 LNX1_MOUSE Lnx NM_001159577 O70263 O70264 Q8BRI8 Q8CFR3 uc008xtt.1 uc008xtt.2 uc008xtt.3 uc008xtt.4 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with CXADR. Interacts with MAGEB18 and MAGEF1 (By similarity). Interacts with the phosphotyrosine interaction domain of all isoforms of NUMB. IGSF5/JAM4 interacts with isoform 2 through the second PDZ domain, other isoforms may also interact with IGSF5/JAM4. Cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=LNX, LNXp80; IsoId=O70263-1; Sequence=Displayed; Name=2; Synonyms=LNX-B, LNXp70; IsoId=O70263-2; Sequence=VSP_005734; Name=3; IsoId=O70263-3; Sequence=VSP_005734, VSP_012588, VSP_012589; Isoform 1 and isoform 2 are expressed in the heart. Isoform 1 is also expressed in kidney, lung and skeletal muscle while isoform 2 is also expressed in brain. The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient. The PDZ 1 domain participates in the interaction with the PID domain of NUMB, and participates in the isoform-specific ubiquitination of NUMB. The PDZ 2 domain of isoform 2 participates in the interaction with IGSF5/JAM4, other isoforms containing this domain may also interact with IGSF5/JAM4. ubiquitin-protein transferase activity protein binding cytoplasm ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity PDZ domain binding identical protein binding metal ion binding uc008xtt.1 uc008xtt.2 uc008xtt.3 uc008xtt.4 
ENSMUST00000117396.3 Ncapg ENSMUST00000117396.3 non-SMC condensin I complex, subunit G (from RefSeq NM_019438.2) E9PWG6 E9PWG6_MOUSE ENSMUST00000117396.1 ENSMUST00000117396.2 NM_019438 Ncapg uc008xjf.1 uc008xjf.2 uc008xjf.3 uc008xjf.4 Chromosome Belongs to the CND3 (condensin subunit 3) family. condensed chromosome, centromeric region condensed chromosome condensin complex molecular_function cytoplasm mitotic chromosome condensation uc008xjf.1 uc008xjf.2 uc008xjf.3 uc008xjf.4 
ENSMUST00000117399.2 Msn ENSMUST00000117399.2 moesin (from RefSeq NM_010833.2) B1AX70 ENSMUST00000117399.1 MOES_MOUSE Msn NM_010833 P26041 Q3UL28 Q8BSN4 uc009tug.1 uc009tug.2 uc009tug.3 Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (By similarity). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (By similarity). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (By similarity). The role of moesin is particularly important in immunity acting on both T and B- cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:22875842). Modulates phagolysosomal biogenesis in macrophages (PubMed:28978692). Participates also in immunologic synapse formation (By similarity). In resting T-cells, part of a PAG1-NHERF1-MSN complex which is disrupted upon TCR activation (PubMed:11777944). Interacts with NHERF1 (PubMed:11777944). Interacts with PPP1R16B (By similarity). Interacts with SELPLG and SYK; these interactions mediate the activation of SYK by SELPLG (By similarity). Interacts with PDPN (via cytoplasmic domain); this interaction activates RHOA and promotes epithelial- mesenchymal transition (By similarity). Interacts with SPN/CD43 cytoplasmic tail (PubMed:9472040). Interacts with CD44 (PubMed:9472040). Interacts with ICAM2 (PubMed:9472040). Interacts with ICAM3 (via C-terminus) (By similarity). Interacts with PDZD8 (By similarity). Interacts with F-actin (By similarity). Interacts with CD46 (By similarity). Interacts with PTPN6 (PubMed:29247647). Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Apical cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, microvillus membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, microvillus Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment (By similarity). Localizes at the uropods of T lymphoblasts (By similarity). The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex. Phosphorylation on Thr-558 by STK10 negatively regulates lymphocyte migration and polarization (By similarity). Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. S-nitrosylation of Cys-117 is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) implicating the iNOS-S100A8/9 transnitrosylase complex. Moesin-deficient mice exhibit no obvious abnormalities in appearance or fertility, but display altered humoral immune responses. immunological synapse formation uropod double-stranded RNA binding actin binding receptor binding protein binding cytoplasm cytosol cytoskeleton plasma membrane microvillus focal adhesion leukocyte cell-cell adhesion cytoskeletal protein binding regulation of cell shape regulation of cell size cytoplasmic side of plasma membrane cell surface positive regulation of gene expression membrane basolateral plasma membrane apical plasma membrane enzyme binding protein kinase binding gland morphogenesis membrane to membrane docking filopodium T-tubule secretory granule membrane pseudopodium filopodium membrane microvillus membrane T cell proliferation cell projection myelin sheath apical part of cell establishment of epithelial cell apical/basal polarity perinuclear region of cytoplasm cell adhesion molecule binding leukocyte migration cell tip establishment of endothelial barrier T cell aggregation cellular response to testosterone stimulus invadopodium positive regulation of podosome assembly cell periphery T cell migration regulation of organelle assembly positive regulation of protein localization to early endosome positive regulation of cellular protein catabolic process regulation of lymphocyte migration positive regulation of early endosome to late endosome transport uc009tug.1 uc009tug.2 uc009tug.3 
ENSMUST00000117406.8 Sva ENSMUST00000117406.8 Monomer. Interacts with AZGP1. (from UniProt E9PX96) E9PX96 E9PX96_MOUSE ENSMUST00000117406.1 ENSMUST00000117406.2 ENSMUST00000117406.3 ENSMUST00000117406.4 ENSMUST00000117406.5 ENSMUST00000117406.6 ENSMUST00000117406.7 M94179 Sva uc291dwt.1 uc291dwt.2 Monomer. Interacts with AZGP1. Belongs to the PIP family. regulation of immune system process aspartic-type endopeptidase activity extracellular region extracellular space proteolysis membrane integral component of membrane cellular response to steroid hormone stimulus uc291dwt.1 uc291dwt.2 
ENSMUST00000117413.9 Nlrp4b ENSMUST00000117413.9 NLR family, pyrin domain containing 4B, transcript variant 2 (from RefSeq NM_001355151.1) ENSMUST00000117413.1 ENSMUST00000117413.2 ENSMUST00000117413.3 ENSMUST00000117413.4 ENSMUST00000117413.5 ENSMUST00000117413.6 ENSMUST00000117413.7 ENSMUST00000117413.8 NAL4B_MOUSE NM_001355151 Nalp4b Q66X16 Q8C6J9 uc009fdj.1 uc009fdj.2 uc009fdj.3 May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Belongs to the NLRP family. nucleotide binding molecular_function ATP binding cellular_component inflammatory response biological_process uc009fdj.1 uc009fdj.2 uc009fdj.3 
ENSMUST00000117422.2 Creb3l3 ENSMUST00000117422.2 cAMP responsive element binding protein 3-like 3, transcript variant 2 (from RefSeq NM_145365.3) CR3L3_MOUSE Crebh ENSMUST00000117422.1 NM_145365 Q8BWS0 Q91XE9 uc007gfw.1 uc007gfw.2 uc007gfw.3 Transcription factor that may act during endoplasmic reticulum (ER) stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. Binds to the cAMP response element (CRE). Activates transcription through box-B element (By similarity). Activates transcription through CRE. May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (PubMed:30389664). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations (PubMed:21666694). Binds DNA as a dimer. May form homodimers (By similarity). Interacts with ATF6 (By similarity). Interacts with SYNV1/HRD1; this interaction leads to CREB3L3 ubiquitination and proteasomal degradation (PubMed:30389664). Endoplasmic reticulum membrane ; Single-pass type II membrane protein [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. Expressed in adult liver (at protein level) and small intestine. By IL6. Pro-inflammatory cytokines and lipopolysaccharide activate the UPR and induce cleavage of CREBH in the liver (PubMed:16469704). Down-regulated in the liver during fasting- refeeding. This down-regulation may occur at the postranscriptional level and may be mediated by SYNV1/HRD1, which induces CREB3L3 ubiquitination and proteasomal degradation (PubMed:30389664). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (By similarity). N-glycosylation is required for optimal proteolytic activation. Ubiquitinated at Lys-290 by SYNV1/HRD1 via 'Lys-27'-linked ubiquitin. Knockout mice display decreased triglyceride clearance from plasma resulting in hypertriglyceridemia. Belongs to the bZIP family. ATF subfamily. transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol regulation of transcription, DNA-templated response to unfolded protein membrane integral component of membrane endoplasmic reticulum unfolded protein response cAMP response element binding protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress uc007gfw.1 uc007gfw.2 uc007gfw.3 
ENSMUST00000117440.8 Chpt1 ENSMUST00000117440.8 choline phosphotransferase 1, transcript variant 1 (from RefSeq NM_001146690.1) Chpt1 D3YU39 D3YU39_MOUSE ENSMUST00000117440.1 ENSMUST00000117440.2 ENSMUST00000117440.3 ENSMUST00000117440.4 ENSMUST00000117440.5 ENSMUST00000117440.6 ENSMUST00000117440.7 NM_001146690 uc011xlh.1 uc011xlh.2 uc011xlh.3 Reaction=1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn- glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54232, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:76979, ChEBI:CHEBI:78228; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54233; Evidence=; Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z- docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54332, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:74963, ChEBI:CHEBI:82949; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54333; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54244, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:73001, ChEBI:CHEBI:75466; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54245; Evidence=; Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn- glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54344, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:74965, ChEBI:CHEBI:75728; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54345; Evidence=; Reaction=a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn- glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:32939, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57643, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377; EC=2.7.8.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32940; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Lipid metabolism. Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2. Golgi apparatus membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the CDP-alcohol phosphatidyltransferase class-I family. diacylglycerol cholinephosphotransferase activity phosphatidylcholine biosynthetic process CDP-choline pathway platelet activating factor biosynthetic process phospholipid biosynthetic process membrane integral component of membrane transferase activity phosphotransferase activity, for other substituted phosphate groups uc011xlh.1 uc011xlh.2 uc011xlh.3 
ENSMUST00000117445.2 Gm49340 ENSMUST00000117445.2 Gm49340 (from geneSymbol) AK133348 B0QZP0 B0QZP0_MOUSE ENSMUST00000117445.1 Gm49340 uc011xys.1 uc011xys.2 uc011xys.3 meiotic DNA repair synthesis synapsis gamete generation uc011xys.1 uc011xys.2 uc011xys.3 
ENSMUST00000117513.8 Slc29a3 ENSMUST00000117513.8 solute carrier family 29 (nucleoside transporters), member 3 (from RefSeq NM_023596.3) B2RQD3 ENSMUST00000117513.1 ENSMUST00000117513.2 ENSMUST00000117513.3 ENSMUST00000117513.4 ENSMUST00000117513.5 ENSMUST00000117513.6 ENSMUST00000117513.7 Ent3 NM_023596 Q99P65 S29A3_MOUSE Slc29a3 uc007ffb.1 uc007ffb.2 Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes (PubMed:15701636, PubMed:22174130). Functions as a non-electrogenic Na(+)-independent transporter (PubMed:15701636). Substrate transport is pH-dependent and enhanced under acidic condition, probably reflecting the location of the transporter in acidic intracellular compartments (PubMed:15701636). Proton is not a cotransporting ion but most likely change the ionization state of the transporter which dictates transport-permissible/impermissible conformation for nucleoside translocation (By similarity). May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate the fundamental function of salvage synthesis of nucleic acids (PubMed:22174130). Involved in the transport of nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine) and deoxynucleosides (deoxyadenosine, deoxycytidine) (PubMed:15701636, PubMed:22174130). Also mediates transport of purine nucleobases (adenine, guanine), and pyrimidine nucleobases (uracil) (PubMed:15701636). Also able to transport monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine (By similarity). Capable of transporting ATP (By similarity). Mediates nucleoside export from lysosomes in macrophages, which regulates macrophage functions and numbers (PubMed:22174130). Reaction=adenosine(in) = adenosine(out); Xref=Rhea:RHEA:75343, ChEBI:CHEBI:16335; Evidence= Reaction=guanosine(in) = guanosine(out); Xref=Rhea:RHEA:75371, ChEBI:CHEBI:16750; Evidence=; Reaction=inosine(in) = inosine(out); Xref=Rhea:RHEA:75375, ChEBI:CHEBI:17596; Evidence=; Reaction=uridine(out) = uridine(in); Xref=Rhea:RHEA:71519, ChEBI:CHEBI:16704; Evidence=; Reaction=cytidine(in) = cytidine(out); Xref=Rhea:RHEA:75367, ChEBI:CHEBI:17562; Evidence=; Reaction=thymidine(in) = thymidine(out); Xref=Rhea:RHEA:75363, ChEBI:CHEBI:17748; Evidence=; Reaction=2'-deoxyadenosine(in) = 2'-deoxyadenosine(out); Xref=Rhea:RHEA:75691, ChEBI:CHEBI:17256; Evidence=; Reaction=2'-deoxycytidine(in) = 2'-deoxycytidine(out); Xref=Rhea:RHEA:75695, ChEBI:CHEBI:15698; Evidence=; Reaction=guanine(out) = guanine(in); Xref=Rhea:RHEA:71531, ChEBI:CHEBI:16235; Evidence=; Reaction=uracil(in) = uracil(out); Xref=Rhea:RHEA:69404, ChEBI:CHEBI:17568; Evidence=; Reaction=(R)-noradrenaline(out) = (R)-noradrenaline(in); Xref=Rhea:RHEA:73871, ChEBI:CHEBI:72587; Evidence=; Reaction=dopamine(out) = dopamine(in); Xref=Rhea:RHEA:73863, ChEBI:CHEBI:59905; Evidence=; Reaction=serotonin(out) = serotonin(in); Xref=Rhea:RHEA:73867, ChEBI:CHEBI:350546; Evidence=; Reaction=tyramine(in) = tyramine(out); Xref=Rhea:RHEA:74783, ChEBI:CHEBI:327995; Evidence=; Reaction=ATP(in) = ATP(out); Xref=Rhea:RHEA:75687, ChEBI:CHEBI:30616; Evidence=; Lysosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Expressed in macrophages. Contains a N-terminal dileucine motif (DE)XXXL(LI) important for endosomal/lysosomal and mitochondrial subcellular localization. Knockout mice show lysosomal nucleoside buildup, elevated intralysosomal pH, altered macrophage function, and develop spontaneous and progressive macrophage-dominated histiocytosis. A truncated version of SLC29A3/mENT3 in which the N- terminal 36 amino acids are deleted, enables cell-surface localization of an otherwise intracellular transporter, and is utilized to investigate the transporter activity. Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. In contrast with human ortholog, adenosine transport may be not pH-dependent. nucleoside transmembrane transporter activity lysosome lysosomal membrane endosome Golgi apparatus plasma membrane nucleoside transport membrane integral component of membrane late endosome membrane intracellular membrane-bounded organelle nucleoside transmembrane transport uc007ffb.1 uc007ffb.2 
ENSMUST00000117549.8 Ube4a ENSMUST00000117549.8 ubiquitination factor E4A, transcript variant 4 (from RefSeq NM_001361076.1) ENSMUST00000117549.1 ENSMUST00000117549.2 ENSMUST00000117549.3 ENSMUST00000117549.4 ENSMUST00000117549.5 ENSMUST00000117549.6 ENSMUST00000117549.7 G3X9Y5 G3X9Y5_MOUSE NM_001361076 Ube4a uc292gtd.1 uc292gtd.2 Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys- 48'-linked polyubiquitination of substrates. Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence= Protein modification; protein ubiquitination. Cytoplasm The U-box domain is required for the ubiquitin protein ligase activity. Belongs to the ubiquitin conjugation factor E4 family. ubiquitin ligase complex ubiquitin-protein transferase activity ubiquitin-dependent protein catabolic process protein ubiquitination ubiquitin-ubiquitin ligase activity uc292gtd.1 uc292gtd.2 
ENSMUST00000117550.2 Lilra5 ENSMUST00000117550.2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 (from RefSeq NM_001081239.2) D3Z7A9 D3Z7A9_MOUSE ENSMUST00000117550.1 Lilra5 NM_001081239 uc009exf.1 uc009exf.2 uc009exf.3 molecular_function extracellular space cell surface membrane integral component of membrane positive regulation of MAPK cascade positive regulation of interleukin-1 beta secretion positive regulation of inflammatory response positive regulation of cell activation positive regulation of calcium ion transport positive regulation of protein tyrosine kinase activity positive regulation of tumor necrosis factor secretion negative regulation of interleukin-13 secretion positive regulation of interleukin-6 secretion positive regulation of interleukin-10 secretion negative regulation of interleukin-12 secretion uc009exf.1 uc009exf.2 uc009exf.3 
ENSMUST00000117551.4 Rasa3 ENSMUST00000117551.4 RAS p21 protein activator 3 (from RefSeq NM_009025.2) ENSMUST00000117551.1 ENSMUST00000117551.2 ENSMUST00000117551.3 NM_009025 Q60790 Q6PG24 Q925V1 RASA3_MOUSE uc009kye.1 uc009kye.2 uc009kye.3 Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4). High levels in brain, lower in spleen and lung. GTPase activator activity signal transduction calcium-release channel activity intrinsic component of the cytoplasmic side of the plasma membrane cellular response to heat intracellular signal transduction regulation of GTPase activity positive regulation of GTPase activity negative regulation of Ras protein signal transduction metal ion binding release of sequestered calcium ion into cytosol uc009kye.1 uc009kye.2 uc009kye.3 
ENSMUST00000117556.8 D630045J12Rik ENSMUST00000117556.8 D630045J12Rik (from geneSymbol) BC079889 D3YTS3 D3YTS3_MOUSE D630045J12Rik ENSMUST00000117556.1 ENSMUST00000117556.2 ENSMUST00000117556.3 ENSMUST00000117556.4 ENSMUST00000117556.5 ENSMUST00000117556.6 ENSMUST00000117556.7 uc291doz.1 uc291doz.2 membrane integral component of membrane uc291doz.1 uc291doz.2 
ENSMUST00000117558.3 H2bc26 ENSMUST00000117558.3 H2B clustered histone 26 (from RefSeq NM_001393523.1) ENSMUST00000117558.1 ENSMUST00000117558.2 H2B3B_MOUSE H2bc26 H2bc26-ps H2bu1 H2bu1-ps Hist3h2bb Hist3h2bb-ps NM_001393523 Q3B7Z7 Q8CGP0 uc007jcs.1 uc007jcs.2 uc007jcs.3 uc007jcs.4 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. Defined as a pseudogene by MGI. However, proteomics data suggest the existence of the protein. Sequence=AAI07303.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAO06253.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleosome DNA binding nucleus nucleoplasm chromosome nucleosome assembly protein heterodimerization activity uc007jcs.1 uc007jcs.2 uc007jcs.3 uc007jcs.4 
ENSMUST00000117564.8 Zan ENSMUST00000117564.8 zonadhesin (from RefSeq NM_011741.2) E9PWQ7 E9PWQ7_MOUSE ENSMUST00000117564.1 ENSMUST00000117564.2 ENSMUST00000117564.3 ENSMUST00000117564.4 ENSMUST00000117564.5 ENSMUST00000117564.6 ENSMUST00000117564.7 NM_011741 Zan uc012eey.1 uc012eey.2 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc012eey.1 uc012eey.2 
ENSMUST00000117584.3 Pom121l12 ENSMUST00000117584.3 POM121 membrane glycoprotein-like 12 (from RefSeq NM_001164166.1) A0A1B0GSJ4 A0A1B0GSJ4_MOUSE ENSMUST00000117584.1 ENSMUST00000117584.2 NM_001164166 Pom121l12 uc007ibi.1 uc007ibi.2 uc007ibi.3 uc007ibi.4 nuclear pore protein import into nucleus nuclear localization sequence binding structural constituent of nuclear pore uc007ibi.1 uc007ibi.2 uc007ibi.3 uc007ibi.4 
ENSMUST00000117588.8 Hfm1 ENSMUST00000117588.8 Required for crossover formation and complete synapsis of homologous chromosomes during meiosis. (from UniProt D3Z4R1) BC172050 D3Z4R1 ENSMUST00000117588.1 ENSMUST00000117588.2 ENSMUST00000117588.3 ENSMUST00000117588.4 ENSMUST00000117588.5 ENSMUST00000117588.6 ENSMUST00000117588.7 HFM1_MOUSE Hfm1 uc290xuq.1 uc290xuq.2 Required for crossover formation and complete synapsis of homologous chromosomes during meiosis. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Male and female mutants are sterile due to severe blockage of spermatogenesis and oogenesis. Belongs to the helicase family. SKI2 subfamily. nucleotide binding resolution of meiotic recombination intermediates nucleic acid binding DNA helicase activity helicase activity ATP binding spermatogenesis hydrolase activity cell differentiation DNA duplex unwinding oogenesis meiotic cell cycle uc290xuq.1 uc290xuq.2 
ENSMUST00000117592.2 4930455H04Rik ENSMUST00000117592.2 RIKEN cDNA 4930455H04 gene (from RefSeq NR_040596.1) 4930455H04Rik D3Z622 D3Z622_MOUSE ENSMUST00000117592.1 NR_040596 uc029uoi.1 uc029uoi.2 uc029uoi.3 molecular_function cellular_component biological_process uc029uoi.1 uc029uoi.2 uc029uoi.3 
ENSMUST00000117598.8 Vps8 ENSMUST00000117598.8 VPS8 CORVET complex subunit, transcript variant 1 (from RefSeq NM_001285893.1) ENSMUST00000117598.1 ENSMUST00000117598.2 ENSMUST00000117598.3 ENSMUST00000117598.4 ENSMUST00000117598.5 ENSMUST00000117598.6 ENSMUST00000117598.7 Kiaa0804 NM_001285893 Q0P5W1 Q3UR93 Q80TR5 Q8K280 VPS8_MOUSE uc007yrj.1 uc007yrj.2 uc007yrj.3 uc007yrj.4 Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes (By similarity). Interacts with RAB5C (PubMed:25266290). Interacts with TGFBRAP1 (By similarity). Component of the putative class C core vacuole/endosome tethering (CORVET) complex; the core of which is composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, associated with VPS8 and TGFBRAP1 (PubMed:25266290). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q0P5W1-1; Sequence=Displayed; Name=2; IsoId=Q0P5W1-2; Sequence=VSP_023254, VSP_023255; Name=3; IsoId=Q0P5W1-3; Sequence=VSP_023252, VSP_023253; Belongs to the VPS8 family. Sequence=AAH32214.1; Type=Erroneous initiation; Evidence=; Sequence=BAC26237.1; Type=Frameshift; Evidence=; Sequence=BAC65657.1; Type=Erroneous initiation; Evidence=; molecular_function early endosome CORVET complex endosomal vesicle fusion metal ion binding uc007yrj.1 uc007yrj.2 uc007yrj.3 uc007yrj.4 
ENSMUST00000117611.8 Pld3 ENSMUST00000117611.8 phospholipase D family member 3, transcript variant 1 (from RefSeq NM_001317355.2) ENSMUST00000117611.1 ENSMUST00000117611.2 ENSMUST00000117611.3 ENSMUST00000117611.4 ENSMUST00000117611.5 ENSMUST00000117611.6 ENSMUST00000117611.7 NM_001317355 O35405 PLD3_MOUSE Q3U5M5 Sam9 uc009fwn.1 uc009fwn.2 uc009fwn.3 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (PubMed:30111894). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (PubMed:30111894). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). Reaction=Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates.; EC=3.1.16.1; Evidence=; pH dependence: Optimum pH is 5.5-5. ; Interacts with APP. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Lysosome lumen Early endosome membrane ; Single-pass type II membrane protein Late endosome membrane ; Single-pass type II membrane protein Golgi apparatus membrane ; Single-pass type II membrane protein Endosome membrane ; Single-pass type II membrane protein Note=Localizes to ER-associated vesicles in differentiating myotubes. The soluble form in lysosome arises by proteolytic processing of the membrane-bound form. Expressed at higher level in brain than in non- nervous tissue. Expressed in mature neurons of the forebrain and appears to be turned on at late stages of neurogenesis. Expressed during late neuronal development in the forebrain (PubMed:9813063). Expressed in the pyramidal neurons of the cortex and hippocampus (PubMed:28128235). Low expression in the cerebellum (PubMed:30312375). Up-regulated during myoblast differentiation into myotubes. N-glycosylated. Proteolytically processed to a soluble form that is stable within endosomes and lysosomes. During transport through the secretory pathway becomes proteolysed by cysteine proteases, thereby releasing a stable soluble lysosomal lumenal polypeptide, whereas the transmembrane-bound fragment is rapidly degraded. Its transport route to lysosomes involves ubiquitination and the ESCRT complex. Ubiquitinated. Ubiquitination mediates sorting into lysosomes. Deficient mice exhibit no altered phenotype except a exaggerated response of macrophages to TLR9 (PubMed:30111894). Morphology of PLD3-deficient brains does not reveal any major abnormalities but an altered lysosomal structure (PubMed:29386126). PDL3 and PLD4 double-deficient mice are unable to survive beyond the age of 21 days due to severe liver inflammation (PubMed:30111894). Livers from double-knockout mice develop lethal hepatic autoinflammatory disease that could be prevented by a single allele of either PDL3 or PLD4 (PubMed:30111894). Belongs to the phospholipase D family. It was initially thought that PDL3 has phospholipase D activity due to its HKD motifs. The second HKD motif contains Glu instead of the canonical Asp. Its enzyme activity is therefore unsure. Catalytic phospholipase D activity is still controversial (PubMed:30312375, PubMed:9813063) (By similarity). Its closest homolog PLD4, exhibits no phospholipase activity (By similarity). catalytic activity phospholipase D activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process membrane integral component of membrane lipid catabolic process hydrolase activity N-acylphosphatidylethanolamine-specific phospholipase D activity uc009fwn.1 uc009fwn.2 uc009fwn.3 
ENSMUST00000117638.2 Zfp534 ENSMUST00000117638.2 zinc finger protein 534 (from RefSeq NM_001127188.2) A2A7A1 A2A7A1_MOUSE ENSMUST00000117638.1 NM_001127188 Zfp534 uc012dpe.1 uc012dpe.2 uc012dpe.3 uc012dpe.4 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc012dpe.1 uc012dpe.2 uc012dpe.3 uc012dpe.4 
ENSMUST00000117646.8 Dixdc1 ENSMUST00000117646.8 DIX domain containing 1, transcript variant 3 (from RefSeq NM_001374656.1) Ccd1 DIXC1_MOUSE ENSMUST00000117646.1 ENSMUST00000117646.2 ENSMUST00000117646.3 ENSMUST00000117646.4 ENSMUST00000117646.5 ENSMUST00000117646.6 ENSMUST00000117646.7 Kiaa1735 NM_001374656 Q3TPF4 Q3UQ90 Q5DPZ2 Q5DPZ3 Q5DPZ4 Q5DPZ6 Q6ZPJ2 Q80Y83 Q8C467 Q8R1C1 uc009pkf.1 uc009pkf.2 uc009pkf.3 uc009pkf.4 Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. May bind filamentous actin. Directly interacts (via DIX domain) with DVL2 (via DIX domain). Interacts with gamma-tubulin (By similarity). Interacts with the complex composed of DVL2 and Rac. Interacts with AXIN1; competes with MAP3K1. Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1. Cell junction, focal adhesion Cytoplasm, cytoskeleton, stress fiber Cytoplasm Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis. Associated with actin stress fiber at the filament ends. Event=Alternative splicing; Named isoforms=16; Name=1; Synonyms=Abeta1L; IsoId=Q80Y83-1; Sequence=Displayed; Name=2; Synonyms=Abeta1S; IsoId=Q80Y83-2; Sequence=VSP_025394; Name=3; Synonyms=Aalpha1L; IsoId=Q80Y83-3; Sequence=VSP_025387; Name=4; Synonyms=Aalpha1S; IsoId=Q80Y83-4; Sequence=VSP_025387, VSP_025394; Name=5; Synonyms=Abeta2L; IsoId=Q80Y83-5; Sequence=VSP_025388; Name=6; Synonyms=Abeta2S; IsoId=Q80Y83-6; Sequence=VSP_025388, VSP_025394; Name=7; Synonyms=Aalpha2L; IsoId=Q80Y83-7; Sequence=VSP_025387, VSP_025388; Name=8; Synonyms=Aalpha2S; IsoId=Q80Y83-8; Sequence=VSP_025387, VSP_025388, VSP_025394; Name=9; Synonyms=BbetaL; IsoId=Q80Y83-9; Sequence=VSP_025386, VSP_025391; Name=10; Synonyms=BbetaS; IsoId=Q80Y83-10; Sequence=VSP_025386, VSP_025391, VSP_025394; Name=11; Synonyms=BalphaL; IsoId=Q80Y83-11; Sequence=VSP_025385, VSP_025392; Name=12; Synonyms=BalphaS; IsoId=Q80Y83-12; Sequence=VSP_025385, VSP_025392, VSP_025394; Name=13; Synonyms=CL; IsoId=Q80Y83-13; Sequence=VSP_025383; Name=14; Synonyms=CS; IsoId=Q80Y83-14; Sequence=VSP_025383, VSP_025394; Name=15; IsoId=Q80Y83-15; Sequence=VSP_025384, VSP_025393, VSP_025395, VSP_025396; Name=16; IsoId=Q80Y83-16; Sequence=VSP_025387, VSP_025389, VSP_025390; Abundantly expressed in brain and testis and to a lower extent in lung, kidney, colon, ovary and urinary bladder. Expressed in brain, liver, testis and spleen (at protein level). Expressed throughout the brain with strong expression in main and accessory olfactory bulbs, cerebral cortex, piriform cortex, hippocampus, habenular nucleus, dorsal thalamus, superior and inferior colliculi and cerebellum. Expressed in embryonic brain, liver and spleen (at protein level). First detected at 7.5 dpc in the node. Expressed in the cephalic mesenchyme and tail bud at 8.5 dpc, and in the branchial arch and forelimb bud at 9.5 dpc. In the central nervous system, expression begins and persists in the regions where the neurons differentiate. Expression is also strong in the peripheral nervous system, including sensory cranial ganglia, dorsal root ganglia, and autonomic ganglia, and in the sensory organs, such as the inner nuclear layer of the neural retina, saccule and cochlea of the inner ear, and nasal epithelium. Outside the nervous system, expression is detected in the cartilage, tongue, lung bud, stomach, and gonad from 12.5 dpc to 14.5 dpc, and in the tooth bud, bronchial epithelium, and kidney at 17.5 dpc. The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation through MAP3K4. The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through MAP3K1. Mediates interaction with DVL2; this interaction is required for activation of Wnt signaling (By similarity). Phosphorylated on tyrosine and serine residues. Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation. [Isoform 5]: Major isoform. [Isoform 7]: Major isoform. [Isoform 11]: Major isoform. Belongs to the DIXDC1 family. actin binding protein binding cytoplasm cytosol cytoskeleton focal adhesion multicellular organism development Wnt signaling pathway protein domain specific binding cerebellar cortex development cerebral cortex cell migration cerebral cortex radially oriented cell migration cell proliferation in forebrain forebrain ventricular zone progenitor cell division cell junction positive regulation of Wnt signaling pathway mitogen-activated protein kinase kinase kinase binding regulation of actin cytoskeleton organization macromolecular complex gamma-tubulin binding neuronal cell body axon terminus negative regulation of neuron differentiation positive regulation of JNK cascade positive regulation of axonogenesis canonical Wnt signaling pathway regulation of microtubule cytoskeleton organization uc009pkf.1 uc009pkf.2 uc009pkf.3 uc009pkf.4 
ENSMUST00000117648.9 Ttc3 ENSMUST00000117648.9 tetratricopeptide repeat domain 3 (from RefSeq NM_009441.2) ENSMUST00000117648.1 ENSMUST00000117648.2 ENSMUST00000117648.3 ENSMUST00000117648.4 ENSMUST00000117648.5 ENSMUST00000117648.6 ENSMUST00000117648.7 ENSMUST00000117648.8 G5E8T2 G5E8T2_MOUSE NM_009441 Ttc3 uc008aaz.1 uc008aaz.2 uc008aaz.3 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Cytoplasm ubiquitin-protein transferase activity nucleus nucleolus cytosol ubiquitin-dependent protein catabolic process protein K48-linked ubiquitination uc008aaz.1 uc008aaz.2 uc008aaz.3 
ENSMUST00000117654.3 Tbrg1 ENSMUST00000117654.3 transforming growth factor beta regulated gene 1 (from RefSeq NM_025289.3) ENSMUST00000117654.1 ENSMUST00000117654.2 NM_025289 Niam Q3TLE7 Q3UB74 Q3UCG2 Q3YBR3 Q6P067 Q80XA1 Q8CGC5 TBRG1_MOUSE uc009ovh.1 uc009ovh.2 uc009ovh.3 Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. Interacts with CDKN2A and MDM2. Nucleus Induced in cells undergoing arrest in response to DNA damage and TGFB1 treatment. Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation. Belongs to the TBRG1 family. Sequence=AAH21331.1; Type=Erroneous initiation; Evidence=; Sequence=AAH40813.3; Type=Erroneous initiation; Evidence=; Sequence=AAH43022.3; Type=Erroneous initiation; Evidence=; Sequence=AAH65795.1; Type=Erroneous initiation; Evidence=; molecular_function nucleus DNA replication cell cycle cell cycle arrest negative regulation of cell proliferation protein stabilization protein localization to nucleoplasm uc009ovh.1 uc009ovh.2 uc009ovh.3 
ENSMUST00000117661.9 Stim2 ENSMUST00000117661.9 stromal interaction molecule 2, transcript variant 3 (from RefSeq NM_054083.2) ENSMUST00000117661.1 ENSMUST00000117661.2 ENSMUST00000117661.3 ENSMUST00000117661.4 ENSMUST00000117661.5 ENSMUST00000117661.6 ENSMUST00000117661.7 ENSMUST00000117661.8 Kiaa1482 NM_054083 P83093 Q69ZI3 Q80VF4 STIM2_MOUSE uc008xlq.1 uc008xlq.2 uc008xlq.3 uc008xlq.4 Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx (By similarity). Oligomer with STIM1. Interacts with ORAI1 (By similarity). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration. Glycosylated. Phosphorylated predominantly on Ser residues. Sequence=BAD32461.1; Type=Erroneous initiation; Evidence=; store-operated calcium entry calcium channel regulator activity calcium ion binding protein binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane ion transport calcium ion transport cellular calcium ion homeostasis store-operated calcium channel activity membrane integral component of membrane activation of store-operated calcium channel activity metal ion binding positive regulation of calcium ion transport calcium ion transmembrane transport uc008xlq.1 uc008xlq.2 uc008xlq.3 uc008xlq.4 
ENSMUST00000117704.2 Or8k36-ps1 ENSMUST00000117704.2 Or8k36-ps1 (from geneSymbol) ENSMUST00000117704.1 NR_190775 uc289xst.1 uc289xst.2 uc289xst.1 uc289xst.2 
ENSMUST00000117726.9 Abhd3 ENSMUST00000117726.9 Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids. (from UniProt Q91ZH7) ABHD3_MOUSE AK144238 Abhd3 ENSMUST00000117726.1 ENSMUST00000117726.2 ENSMUST00000117726.3 ENSMUST00000117726.4 ENSMUST00000117726.5 ENSMUST00000117726.6 ENSMUST00000117726.7 ENSMUST00000117726.8 Labh3 Q3UNF7 Q91ZH7 uc289nyt.1 uc289nyt.2 Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids. Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18690; Evidence=; Reaction=1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H(+) + tetradecanoate; Xref=Rhea:RHEA:54388, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:76084, ChEBI:CHEBI:86094; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54389; Evidence=; Reaction=1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-tetradecanoyl- sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:54392, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:64489, ChEBI:CHEBI:86094; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54393; Evidence=; Reaction=1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn- glycero-3-phosphocholine + H(+) + tetradecanoate; Xref=Rhea:RHEA:54396, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:76079, ChEBI:CHEBI:86102; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54397; Evidence=; Reaction=1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn- glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z- docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate; Xref=Rhea:RHEA:54400, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:76085, ChEBI:CHEBI:86162; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54401; Evidence=; Reaction=1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2- tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate; Xref=Rhea:RHEA:54404, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:45240, ChEBI:CHEBI:131738; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54405; Evidence=; Reaction=1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1- octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:54408, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:73858, ChEBI:CHEBI:75220; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54409; Evidence=; Reaction=1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1- tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate; Xref=Rhea:RHEA:54456, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:45240, ChEBI:CHEBI:64489; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54457; Evidence=; Reaction=1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate; Xref=Rhea:RHEA:54460, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:31011, ChEBI:CHEBI:73858, ChEBI:CHEBI:138211; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54461; Evidence=; Reaction=1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate; Xref=Rhea:RHEA:54464, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:73858, ChEBI:CHEBI:138212; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54465; Evidence=; Reaction=1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate; Xref=Rhea:RHEA:54468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:73858, ChEBI:CHEBI:138213; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54469; Evidence=; Reaction=1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate; Xref=Rhea:RHEA:54472, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32361, ChEBI:CHEBI:73858, ChEBI:CHEBI:138214; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54473; Evidence=; Reaction=1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate; Xref=Rhea:RHEA:54552, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64496, ChEBI:CHEBI:78208, ChEBI:CHEBI:138269; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54553; Evidence=; Reaction=1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate; Xref=Rhea:RHEA:41388, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:78207, ChEBI:CHEBI:78208; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41389; Evidence=; Reaction=1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+); Xref=Rhea:RHEA:41179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:61042, ChEBI:CHEBI:72998, ChEBI:CHEBI:77812; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41180; Evidence=; Reaction=1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+); Xref=Rhea:RHEA:40483, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16120, ChEBI:CHEBI:72998, ChEBI:CHEBI:77890; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40484; Evidence=; Reaction=1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+); Xref=Rhea:RHEA:41159, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30921, ChEBI:CHEBI:72998, ChEBI:CHEBI:77756; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41160; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1- O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:40479, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:44811, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40480; Evidence=; Membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91ZH7-1; Sequence=Displayed; Name=2; IsoId=Q91ZH7-2; Sequence=VSP_023564; Widely expressed with higher expression in liver. Detected in embryos from 7 dpc to 17 dpc. Mice lacking Abhd3 are viable, fertile and have normal behavior. Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. phospholipase A2 activity cellular_component lipid metabolic process phosphatidylcholine 1-acylhydrolase activity membrane integral component of membrane lipase activity hydrolase activity cellular lipid metabolic process phosphatidylcholine metabolic process acylglycerol lipase activity carboxylic ester hydrolase activity phosphatidylserine 1-acylhydrolase activity 1-acyl-2-lysophosphatidylserine acylhydrolase activity uc289nyt.1 uc289nyt.2 
ENSMUST00000117766.8 Mrpl1 ENSMUST00000117766.8 mitochondrial ribosomal protein L1, transcript variant 1 (from RefSeq NM_053158.3) ENSMUST00000117766.1 ENSMUST00000117766.2 ENSMUST00000117766.3 ENSMUST00000117766.4 ENSMUST00000117766.5 ENSMUST00000117766.6 ENSMUST00000117766.7 NM_053158 Q3UQP5 Q8K351 Q99N96 Q9CWW4 RM01_MOUSE uc008yfi.1 uc008yfi.2 uc008yfi.3 uc008yfi.4 Mitochondrion Belongs to the universal ribosomal protein uL1 family. Sequence=AAH61042.1; Type=Erroneous initiation; Evidence=; Sequence=BAB26866.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB26866.1; Type=Frameshift; Evidence=; Sequence=BAB40837.1; Type=Erroneous initiation; Evidence=; maturation of LSU-rRNA RNA binding structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation large ribosomal subunit 90S preribosome uc008yfi.1 uc008yfi.2 uc008yfi.3 uc008yfi.4 
ENSMUST00000117782.8 Adamtsl4 ENSMUST00000117782.8 ADAMTS-like 4, transcript variant 2 (from RefSeq NM_144899.3) ATL4_MOUSE Adamtsl4 ENSMUST00000117782.1 ENSMUST00000117782.2 ENSMUST00000117782.3 ENSMUST00000117782.4 ENSMUST00000117782.5 ENSMUST00000117782.6 ENSMUST00000117782.7 NM_144899 Q148X6 Q80T21 Tsrc1 uc008qkn.1 uc008qkn.2 uc008qkn.3 The protein encoded by this gene is a member of the ADAMTS superfamily of secreted proteins, which contain a metalloprotease domain at the N-terminus and a C-terminal ancillary domain. ADAMTS-like proteins lack protease activity and resemble the ancillary domain of ADAMTS proteins. ADAMTS-like proteins have been implicated in regulation of the extracellular matrix. The encoded protein contains 7 thrombospondin type 1 repeats, a conserved extracellular domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (By similarity). Interacts with CTSB. Interacts with FBN1 (By similarity). Secreted, extracellular space, extracellular matrix Note=Colocalizes with FMN1 microfibrils in the eye ECM. Widely expressed in a range of tissues. Especially prevalent in brain, spinal cord, muscle, lung and heart. Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1- X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). Although similar to members of the ADAMTS family, it lacks the metalloprotease and disintegrin-like domains which are typical of that family. protease binding epithelial cell development extracellular region interstitial matrix extracellular space proteolysis apoptotic process peptidase activity extracellular matrix organization extracellular matrix positive regulation of apoptotic process uc008qkn.1 uc008qkn.2 uc008qkn.3 
ENSMUST00000117786.9 Csnk1e ENSMUST00000117786.9 casein kinase 1, epsilon, transcript variant 1 (from RefSeq NM_013767.8) ENSMUST00000117786.1 ENSMUST00000117786.2 ENSMUST00000117786.3 ENSMUST00000117786.4 ENSMUST00000117786.5 ENSMUST00000117786.6 ENSMUST00000117786.7 ENSMUST00000117786.8 KC1E_MOUSE NM_013767 Q8R389 Q9JMK2 uc011zwb.1 uc011zwb.2 uc011zwb.3 The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (By similarity). Participates in Wnt signaling (By similarity). Phosphorylates DVL1 (By similarity). Phosphorylates DVL2 (By similarity). Phosphorylates NEDD9/HEF1 (PubMed:29191835). Central component of the circadian clock (PubMed:18400165, PubMed:19414593, PubMed:21930935). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:18400165, PubMed:19414593, PubMed:21930935). Controls PER1 and PER2 nuclear transport and degradation (PubMed:10848614, PubMed:14701732, PubMed:18400165, PubMed:19414593, PubMed:21930935). Inhibits cytokine-induced granuloytic differentiation (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Phosphorylation leads to a decrease in the catalytic activity. Monomer (By similarity). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (PubMed:11779462). Interacts with ANKRD6 (PubMed:12183362). Interacts with PER1 (By similarity). Interacts with DBNDD2, LRP5, LRP6 and SOCS3 (By similarity). Interacts with SNAI1 (via zinc fingers) (By similarity). Interacts with DDX3X; this interaction greatly enhances CSNK1E affinity for ATP and DVL2 phosphorylation, but inhibits DDX3X ATPase/helicase activity. In the presence of RNA, the interaction is decreased (By similarity). Q9JMK2; O08785: Clock; NbExp=2; IntAct=EBI-771709, EBI-79859; Q9JMK2; O35973: Per1; NbExp=2; IntAct=EBI-771709, EBI-1266764; Q9JMK2; O54943: Per2; NbExp=4; IntAct=EBI-771709, EBI-1266779; Cytoplasm Nucleus Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes. Down-regulated during granulocytic differentiation. Does not show circadian oscillations. Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1. No visible phenotype. Has no apparent effect on circadian oscillation of protein levels. Mice exhibit a small but significant increase in circadian period length. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol protein phosphorylation circadian rhythm Wnt signaling pathway kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation positive regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway growth cone negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process circadian regulation of gene expression cellular protein localization regulation of circadian rhythm neuron projection neuronal cell body rhythmic process circadian behavior canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of beta-amyloid formation regulation of cellular protein localization cellular response to nerve growth factor stimulus ribonucleoprotein complex positive regulation of non-canonical Wnt signaling pathway uc011zwb.1 uc011zwb.2 uc011zwb.3 
ENSMUST00000117787.4 Or4x5-ps1 ENSMUST00000117787.4 Or4x5-ps1 (from geneSymbol) ENSMUST00000117787.1 ENSMUST00000117787.2 ENSMUST00000117787.3 uc289yeu.1 uc289yeu.2 uc289yeu.1 uc289yeu.2 
ENSMUST00000117796.8 Arhgef1 ENSMUST00000117796.8 Rho guanine nucleotide exchange factor 1, transcript variant 16 (from RefSeq NR_182017.1) Arhgef1 E9PUF7 E9PUF7_MOUSE ENSMUST00000117796.1 ENSMUST00000117796.2 ENSMUST00000117796.3 ENSMUST00000117796.4 ENSMUST00000117796.5 ENSMUST00000117796.6 ENSMUST00000117796.7 NR_182017 uc009fqx.1 uc009fqx.2 uc009fqx.3 uc009fqx.4 uc009fqx.5 Membrane G-protein coupled receptor binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity cytoplasm G-protein coupled receptor signaling pathway regulation of Rho protein signal transduction positive regulation of GTPase activity uc009fqx.1 uc009fqx.2 uc009fqx.3 uc009fqx.4 uc009fqx.5 
ENSMUST00000117798.8 Zfr2 ENSMUST00000117798.8 zinc finger RNA binding protein 2 (from RefSeq NM_001034895.3) E9Q5M4 E9Q5M4_MOUSE ENSMUST00000117798.1 ENSMUST00000117798.2 ENSMUST00000117798.3 ENSMUST00000117798.4 ENSMUST00000117798.5 ENSMUST00000117798.6 ENSMUST00000117798.7 NM_001034895 Zfr2 uc007ggs.1 uc007ggs.2 uc007ggs.3 uc007ggs.4 nucleic acid binding RNA binding double-stranded RNA binding single-stranded RNA binding ATP binding nucleus immune response biological_process zinc ion binding transferase activity uc007ggs.1 uc007ggs.2 uc007ggs.3 uc007ggs.4 
ENSMUST00000117801.8 Adcy9 ENSMUST00000117801.8 adenylate cyclase 9, transcript variant 1 (from RefSeq NM_009624.4) ADCY9_MOUSE ENSMUST00000117801.1 ENSMUST00000117801.2 ENSMUST00000117801.3 ENSMUST00000117801.4 ENSMUST00000117801.5 ENSMUST00000117801.6 ENSMUST00000117801.7 NM_009624 P51830 Q61279 uc007xzs.1 uc007xzs.2 uc007xzs.3 uc007xzs.4 Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and by beta- adrenergic receptors. Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro). ; Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic receptor activation. Activity is down-regulated by calcium/calcineurin. Cell membrane ; Multi-pass membrane protein Detected in brain, spleen, lung, liver and testis (at protein level). Detected in brain, especially in hippocampus, cerebellum and neocortex. Found in decreasing order in skeletal muscle, heart, adrenal gland, ovary and brain; and to a lesser extent, in kidney, liver, testis, lung, thymus and spleen. The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate- binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding in utero embryonic development adenylate cyclase activity ATP binding plasma membrane integral component of plasma membrane cAMP biosynthetic process adenylate cyclase-activating G-protein coupled receptor signaling pathway cyclic nucleotide biosynthetic process membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity axon dendrite intracellular signal transduction metal ion binding adenylate cyclase-activating adrenergic receptor signaling pathway uc007xzs.1 uc007xzs.2 uc007xzs.3 uc007xzs.4 
ENSMUST00000117803.2 Ifitm7 ENSMUST00000117803.2 interferon induced transmembrane protein 7 (from RefSeq NM_001270718.1) ENSMUST00000117803.1 G3X9Z2 G3X9Z2_MOUSE Ifitm7 NM_001270718 uc289cpa.1 uc289cpa.2 Belongs to the CD225/Dispanin family. molecular_function plasma membrane membrane integral component of membrane response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication negative regulation of viral entry into host cell defense response to virus type I interferon signaling pathway uc289cpa.1 uc289cpa.2 
ENSMUST00000117805.8 Gng7 ENSMUST00000117805.8 guanine nucleotide binding protein (G protein), gamma 7, transcript variant 2 (from RefSeq NM_010319.4) ENSMUST00000117805.1 ENSMUST00000117805.2 ENSMUST00000117805.3 ENSMUST00000117805.4 ENSMUST00000117805.5 ENSMUST00000117805.6 ENSMUST00000117805.7 GBG7_MOUSE Gngt7 NM_010319 Q61016 Q8JZP6 uc287tep.1 uc287tep.2 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum. G proteins are composed of 3 units, alpha, beta and gamma. Cell membrane ; Lipid-anchor ; Cytoplasmic side Brain. Found in the hippocampus, striatum, midbrain and cortex. Mice display increased startle response but normal prepulse inhibition of the startle response. No effect on survival to weaning, fertility and mortality. Belongs to the G protein gamma family. behavioral fear response GTPase activity heterotrimeric G-protein complex plasma membrane signal transduction receptor guanylyl cyclase signaling pathway G-protein coupled receptor signaling pathway locomotory behavior membrane G-protein beta/gamma-subunit complex G-protein beta-subunit binding regulation of adenylate cyclase activity uc287tep.1 uc287tep.2 
ENSMUST00000117831.8 Aip ENSMUST00000117831.8 aryl-hydrocarbon receptor-interacting protein, transcript variant 1 (from RefSeq NM_016666.4) AIP_MOUSE ENSMUST00000117831.1 ENSMUST00000117831.2 ENSMUST00000117831.3 ENSMUST00000117831.4 ENSMUST00000117831.5 ENSMUST00000117831.6 ENSMUST00000117831.7 NM_016666 O08915 Q3UJM2 uc008fyq.1 uc008fyq.2 uc008fyq.3 uc008fyq.4 This gene encodes an Hsp90-associated protein that is localized to the cytoplasm. The encoded protein interacts with the aryl hydrocarbon receptor (AhR) and the tyrosine kinase receptor RET, inhibits AhR ubiquitination, and regulates the intracellular localization of AhR. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex. O08915; P27601: Gna13; NbExp=3; IntAct=EBI-6935014, EBI-2255627; O08915; P21279: Gnaq; NbExp=2; IntAct=EBI-6935014, EBI-771975; O08915; P37242: Thrb; NbExp=2; IntAct=EBI-6935014, EBI-6935043; Cytoplasm. protein peptidyl-prolyl isomerization transcription cofactor activity peptidyl-prolyl cis-trans isomerase activity protein binding cytoplasm cytosol plasma membrane protein targeting to mitochondrion xenobiotic metabolic process regulation of protein kinase A signaling membrane aryl hydrocarbon receptor binding protein maturation by protein folding aryl hydrocarbon receptor complex GAF domain binding unfolded protein binding negative regulation of cyclic-nucleotide phosphodiesterase activity regulation of nucleic acid-templated transcription uc008fyq.1 uc008fyq.2 uc008fyq.3 uc008fyq.4 
ENSMUST00000117860.2 Or5d20-ps1 ENSMUST00000117860.2 Or5d20-ps1 (from geneSymbol) ENSMUST00000117860.1 NR_190802 uc289xxl.1 uc289xxl.2 uc289xxl.1 uc289xxl.2 
ENSMUST00000117865.3 Gm715 ENSMUST00000117865.3 predicted gene 715 (from RefSeq NM_001271548.1) A0A804C8T0 ENSMUST00000117865.1 ENSMUST00000117865.2 Gm715 HAPR2_MOUSE Hapstr2 NM_001271548 uc292oiz.1 uc292oiz.2 Together with HAPSTR1 plays a central regulatory role in the cellular response to molecular stressors, such as DNA damage, nutrient scarcity, and protein misfolding. Regulates these multiple stress response signaling pathways by stabilizing HAPSTR1, but also independently of HAPSTR1. Homooligomer. Heterooligomer with HAPSTR1; the interaction is direct and stabilizes HAPSTR1 independently of HUWE1. Interacts with HUWE1. Nucleus Belongs to the HAPSTR1 family. uc292oiz.1 uc292oiz.2 
ENSMUST00000117880.8 Spmap2l ENSMUST00000117880.8 Deficient mice are viable and have normal fertility. (from UniProt Q9DA15) BC053422 ENSMUST00000117880.1 ENSMUST00000117880.2 ENSMUST00000117880.3 ENSMUST00000117880.4 ENSMUST00000117880.5 ENSMUST00000117880.6 ENSMUST00000117880.7 Q9DA15 SMA2L_MOUSE Spmap2l Thegl uc008xvu.1 uc008xvu.2 Deficient mice are viable and have normal fertility. molecular_function cellular_component biological_process uc008xvu.1 uc008xvu.2 
ENSMUST00000117882.2 Pom121l2 ENSMUST00000117882.2 POM121 transmembrane nucleoporin like 2, transcript variant 2 (from RefSeq NM_001162929.1) ENSMUST00000117882.1 Gm24 NM_001162929 Pom121l2 Q3V0N0 Q3V0N0_MOUSE uc011ywy.1 uc011ywy.2 uc011ywy.1 uc011ywy.2 
ENSMUST00000117890.8 Spsb3 ENSMUST00000117890.8 splA/ryanodine receptor domain and SOCS box containing 3, transcript variant 12 (from RefSeq NM_001400238.1) ENSMUST00000117890.1 ENSMUST00000117890.2 ENSMUST00000117890.3 ENSMUST00000117890.4 ENSMUST00000117890.5 ENSMUST00000117890.6 ENSMUST00000117890.7 Kiaa4204 NM_001400238 Q3U0T8 Q571F5 Q6GQX9 Q8C6A9 Q8R4S9 Q9D7E0 SPSB3_MOUSE Ssb3 Tce1 uc008ayr.1 uc008ayr.2 uc008ayr.3 uc008ayr.4 May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Interacts with MET. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q571F5-1; Sequence=Displayed; Name=2; IsoId=Q571F5-2; Sequence=VSP_023378; Name=3; IsoId=Q571F5-3; Sequence=VSP_023379; Name=4; IsoId=Q571F5-4; Sequence=VSP_023380; The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. Belongs to the SPSB family. Sequence=AAH72556.1; Type=Frameshift; Evidence=; Sequence=BAD90159.1; Type=Erroneous initiation; Evidence=; ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex proteasome-mediated ubiquitin-dependent protein catabolic process uc008ayr.1 uc008ayr.2 uc008ayr.3 uc008ayr.4 
ENSMUST00000117892.2 Slc48a1 ENSMUST00000117892.2 solute carrier family 48 (heme transporter), member 1 (from RefSeq NM_026353.4) ENSMUST00000117892.1 HRG1_MOUSE Hrg1 NM_026353 Q3UU69 Q9D8M3 Q9DCK0 uc007xlb.1 uc007xlb.2 uc007xlb.3 uc007xlb.4 Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. In macrophages of the reticuloendothelial system, is the heme transporter for heme-iron recycling. Essential for macrophage iron homeostasis, transports heme from the phagolysosome to the cytoplasm during erythrophagocytosis (EP). Reaction=heme b(in) = heme b(out); Xref=Rhea:RHEA:75443, ChEBI:CHEBI:60344; Evidence=; Endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein Note=In macrophages, specifically localizes to the phagolysosomal membranes during erythrophagocytosis. Strongly expressed in macrophages of the reticuloendothelial system. Deficient mice fed the standard laboratory rodent diet have peripheral blood counts that are all within the normal range, including the red cell indices. No differences between male and female animals. They show 15% increase in the size of the spleen in. Mutants have hemozoin beginning to accumulate in reticuloendothelial system macrophages 8 days after birth. They require more dietary iron to maintain erythropoiesis than littermate control animals. Belongs to the HRG family. lysosome lysosomal membrane endosome plasma membrane endosome membrane heme transporter activity heme transport membrane integral component of membrane heme binding uc007xlb.1 uc007xlb.2 uc007xlb.3 uc007xlb.4 
ENSMUST00000117913.8 Naip2 ENSMUST00000117913.8 NLR family, apoptosis inhibitory protein 2, transcript variant 1 (from RefSeq NM_010872.3) A9C470 BIR1B_MOUSE Birc1b ENSMUST00000117913.1 ENSMUST00000117913.2 ENSMUST00000117913.3 ENSMUST00000117913.4 ENSMUST00000117913.5 ENSMUST00000117913.6 ENSMUST00000117913.7 NM_010872 Naip-rs6 O09124 Q9QUK4 Q9R030 uc007rqj.1 uc007rqj.2 uc007rqj.3 uc007rqj.4 Sensor component of the NLRC4 inflammasome that specifically recognizes and binds type III secretion system (T3SS) rod proteins such as S.typhimurium (Salmonella) PrgJ and B.thailandensis BsaK from pathogenic bacteria. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri. Prevents motor-neuron apoptosis induced by a variety of signals. Component of the NLRC4 inflammasome, at least composed of NLRC4, caspase-1 (CASP1) and some NAIP protein. Interacts with S.typhimurium (Salmonella) PrgJ and B.thailandensis BsaK. Q9QUK4; Q2T728: BTH_II0824; Xeno; NbExp=2; IntAct=EBI-15944068, EBI-15944060; nucleotide binding immune system process protein binding ATP binding apoptotic process inflammatory response detection of bacterium defense response to bacterium cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process innate immune response metal ion binding pyroptosis cellular response to estrogen stimulus IPAF inflammasome complex uc007rqj.1 uc007rqj.2 uc007rqj.3 uc007rqj.4 
ENSMUST00000117932.2 Mup12 ENSMUST00000117932.2 major urinary protein 12 (from RefSeq NM_001199995.1) ENSMUST00000117932.1 Mup1 Mup10 NM_001199995 Q58ES8 Q58ES8_MOUSE uc008tay.1 uc008tay.2 uc008tay.3 uc008tay.4 uc008tay.5 Secreted Belongs to the calycin superfamily. Lipocalin family. small molecule binding uc008tay.1 uc008tay.2 uc008tay.3 uc008tay.4 uc008tay.5 
ENSMUST00000117944.2 Hs3st1 ENSMUST00000117944.2 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:9346953, PubMed:15060080). Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) (PubMed:9346953, PubMed:15060080). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site (PubMed:9346953, PubMed:15060080). (from UniProt O35310) 3ost 3ost1 AF019385 ENSMUST00000117944.1 HS3S1_MOUSE O35310 uc033ijg.1 uc033ijg.2 uc033ijg.3 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:9346953, PubMed:15060080). Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) (PubMed:9346953, PubMed:15060080). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site (PubMed:9346953, PubMed:15060080). Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:15461, Rhea:RHEA- COMP:9830, Rhea:RHEA-COMP:9831, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:70975; EC=2.8.2.23; Evidence=; Golgi apparatus lumen Belongs to the sulfotransferase 1 family. Golgi apparatus Golgi lumen sulfotransferase activity [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity transferase activity uc033ijg.1 uc033ijg.2 uc033ijg.3 
ENSMUST00000117959.3 Or13c7e-ps1 ENSMUST00000117959.3 Or13c7e-ps1 (from geneSymbol) ENSMUST00000117959.1 ENSMUST00000117959.2 NR_190744 uc290mhv.1 uc290mhv.2 uc290mhv.1 uc290mhv.2 
ENSMUST00000117982.2 Or4p4b-ps1 ENSMUST00000117982.2 Or4p4b-ps1 (from geneSymbol) ENSMUST00000117982.1 NR_190767 uc289xyu.1 uc289xyu.2 uc289xyu.1 uc289xyu.2 
ENSMUST00000117989.2 Ngrn ENSMUST00000117989.2 neugrin, neurite outgrowth associated, transcript variant 2 (from RefSeq NM_031375.4) ENSMUST00000117989.1 Fi58g NGRN_MOUSE NM_031375 Q8C401 Q99KS2 Q99PU9 uc009iaa.1 uc009iaa.2 uc009iaa.3 uc009iaa.4 Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct. Nucleus Secreted Mitochondrion membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99KS2-1; Sequence=Displayed; Name=2; IsoId=Q99KS2-2; Sequence=VSP_039712, VSP_039713; Expressed in heart, brain, liver and kidney. In brain, mainly expressed in neurons rather than glial cells. Level of expression increases with embryonal development. Highly up-regulated in neuroblastostoma cells by RA and MG132 treatment inducing neurite outgrowth. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the neugrin family. Sequence=AAH04034.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB21528.1; Type=Frameshift; Evidence=; Sequence=BAB21528.1; Type=Miscellaneous discrepancy; Note=The N-terminus contains a duplicated region of sequence.; Evidence=; Sequence=BAC38868.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; Sequence=BAE26050.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE26868.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; extracellular region nucleus mitochondrion multicellular organism development membrane rRNA binding cell differentiation mitochondrial membrane positive regulation of mitochondrial translation uc009iaa.1 uc009iaa.2 uc009iaa.3 uc009iaa.4 
ENSMUST00000118009.2 Naf1 ENSMUST00000118009.2 nuclear assembly factor 1 ribonucleoprotein (from RefSeq NM_001163564.1) E9QJT2 E9QJT2_MOUSE ENSMUST00000118009.1 NM_001163564 Naf1 uc009lvu.1 uc009lvu.2 uc009lvu.3 Nucleus Belongs to the NAF1 family. box H/ACA snoRNP assembly pseudouridine synthesis RNA binding nucleus small nucleolar ribonucleoprotein complex ribosome biogenesis positive regulation of telomerase activity telomerase RNA binding telomerase RNA stabilization positive regulation of telomere maintenance via telomere lengthening telomerase holoenzyme complex assembly uc009lvu.1 uc009lvu.2 uc009lvu.3 
ENSMUST00000118022.8 Gata4 ENSMUST00000118022.8 GATA binding protein 4, transcript variant 2 (from RefSeq NM_008092.4) B9EHF7 ENSMUST00000118022.1 ENSMUST00000118022.2 ENSMUST00000118022.3 ENSMUST00000118022.4 ENSMUST00000118022.5 ENSMUST00000118022.6 ENSMUST00000118022.7 GATA4_MOUSE Gata-4 NM_008092 P97491 Q08369 Q9QZK4 uc007uhn.1 uc007uhn.2 uc007uhn.3 uc007uhn.4 Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (PubMed:35182466). In cooperation with TBX5, it binds to cardiac super- enhancers and promotes cardiomyocyte gene expression, while it down- regulates endocardial and endothelial gene expression (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (PubMed:9584153). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity). Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts (via the second Zn finger) with NFATC4 (PubMed:9568714). Interacts with LMCD1 (PubMed:16199866). Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with NR5A1, ZFPM2 and TBX5. Interacts with TBX18. Interacts with GLYR1; the interaction is required for a synergistic activation of GATA4 target genes transcription (By similarity). Q08369; Q62315: Jarid2; NbExp=3; IntAct=EBI-297008, EBI-493592; Q08369; P42582: Nkx2-5; NbExp=4; IntAct=EBI-297008, EBI-297021; Q08369; Q99593: TBX5; Xeno; NbExp=2; IntAct=EBI-297008, EBI-297043; Nucleus Heart, intestine, liver, primative endoderm and gonads. By retinoic acid. Methylation at Lys-299 attenuates transcriptional activity. Sequence=AAA37662.1; Type=Frameshift; Evidence=; nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development gastrulation with mouth forming second endoderm formation positive regulation of protein phosphorylation heart looping heart morphogenesis outflow tract morphogenesis aortic valve morphogenesis atrioventricular valve morphogenesis atrioventricular valve formation mitral valve formation tricuspid valve formation endocardial cushion development cardiac right ventricle morphogenesis ventricular cardiac muscle tissue development cardiac septum development ventricular septum development atrial septum primum morphogenesis atrial septum secundum morphogenesis DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell-cell signaling spermatogenesis heart development transcription factor binding zinc ion binding male gonad development response to mechanical stimulus regulation of gene expression negative regulation of autophagy positive regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of gene expression negative regulation of cardiac muscle cell apoptotic process cardiac muscle hypertrophy in response to stress nuclear body protein kinase binding signal transduction involved in regulation of gene expression positive regulation of BMP signaling pathway response to retinoic acid activating transcription factor binding embryonic heart tube development embryonic heart tube anterior/posterior pattern specification tube morphogenesis skeletal muscle cell differentiation atrioventricular canal development response to drug negative regulation of apoptotic process sequence-specific DNA binding response to estrogen transcription regulatory region DNA binding positive regulation of angiogenesis positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding embryonic digestive tract morphogenesis embryonic morphogenesis embryonic foregut morphogenesis cardiac muscle tissue development NFAT protein binding positive regulation of cardioblast differentiation regulation of protein kinase B signaling cardiac muscle cell differentiation Sertoli cell differentiation regulation of cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation transdifferentiation SMAD protein signal transduction atrial septum morphogenesis lung morphogenesis lung lobe formation diaphragm morphogenesis intestinal epithelial cell differentiation vasculogenesis involved in coronary vascular morphogenesis cardiac muscle tissue regeneration cell growth involved in cardiac muscle cell development positive regulation of ERK1 and ERK2 cascade co-SMAD binding cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus epithelial cell fate commitment seminiferous tubule development regulation of cardiac muscle cell contraction RNA polymerase II transcription factor complex negative regulation of oxidative stress-induced cell death negative regulation of connective tissue replacement negative regulation of apoptotic signaling pathway uc007uhn.1 uc007uhn.2 uc007uhn.3 uc007uhn.4 
ENSMUST00000118060.8 Klra5 ENSMUST00000118060.8 Receptor on natural killer (NK) cells for class I MHC. (from UniProt Q60652) ENSMUST00000118060.1 ENSMUST00000118060.2 ENSMUST00000118060.3 ENSMUST00000118060.4 ENSMUST00000118060.5 ENSMUST00000118060.6 ENSMUST00000118060.7 KLRA5_MOUSE Ly-49e Ly49-e Ly49e Q60652 U10091 uc291jlb.1 uc291jlb.2 Receptor on natural killer (NK) cells for class I MHC. Homodimer; disulfide-linked. Membrane; Single-pass type II membrane protein. Mostly expressed in NK cells, but also observed on NK T and memory T-cells. plasma membrane cell adhesion membrane integral component of membrane carbohydrate binding uc291jlb.1 uc291jlb.2 
ENSMUST00000118068.3 Pira1 ENSMUST00000118068.3 paired-Ig-like receptor A1, transcript variant 2 (from RefSeq NR_163846.1) ENSMUST00000118068.1 ENSMUST00000118068.2 NR_163846 uc291kqu.1 uc291kqu.2 uc291kqu.1 uc291kqu.2 
ENSMUST00000118100.8 Rapgef2 ENSMUST00000118100.8 Rap guanine nucleotide exchange factor (GEF) 2, transcript variant 2 (from RefSeq NM_001310536.2) E9QMD0 ENSMUST00000118100.1 ENSMUST00000118100.2 ENSMUST00000118100.3 ENSMUST00000118100.4 ENSMUST00000118100.5 ENSMUST00000118100.6 ENSMUST00000118100.7 Kiaa0313 NM_001310536 Pdzgef1 Q8CHG7 RPGF2_MOUSE uc290gas.1 uc290gas.2 Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B- Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a neuronal growth factor (NGF)-dependent manner. Interacts (via C- terminal domain) with NEDD4 (via WW domains); this interaction leads to ubiquitination and degradation via the proteasome pathway in a cAMP- independent manner. Interacts with MAGI1 (via PDZ domain). Interacts with ADRB1 (via C-terminal PDZ motif); the interaction is direct. Interacts (via Ras-associating domain) with RAP1A (via GTP-bound active form). Interacts weakly with HRAS (via GDP- and GTP-bound forms). Interacts (via C-terminal domain) with MAGI2 (via PDZ and WW domains). Interacts with CDH1, CTNNB1 and TJP1 (By similarity). Cytoplasm Cytoplasm, perinuclear region Cell membrane Late endosome Cell junction Note=Associated with the synaptic plasma membrane. Localized diffusely in the cytoplasm before neuronal growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with the high affinity nerve growth factor receptor NTRK1 at late endosomes. Translocated to the perinuclear region in a RAP1A-dependent manner. Translocated to the cell membrane. Colocalized with CTNNB1 at cell-cell contacts (By similarity). Expressed in all layers of the cerebral cortex, hippocampus and cerebellum. Expressed in the cortical plate, cingulate cortex and the subventricular zone. Expressed in neurons and endocrine cells (at protein level). Expressed in melanoma cells. Expressed in the yolk sacs at vascular endothelial cells at 7.5 dpc. Expressed in the glial sling (GS) at the cortico- septal boundary at 17.5 dpc (at protein level). The Ras-associating domain is necessary for the Rap guanine nucleotide exchange activity. The N-terminal regionis necessary for cAMP-binding. The PDZ domain is necessary for its targeting to the cell membrane (By similarity). Ubiquitinated by NEDD4, leading to proteasomal degradation. Phosphorylation by PLK2 promotes its activity. Mice appear normal until 7.5 dpc, but become grossly abnormal and dead at mid-gestation. Show severe defects in yolk sac blood and major vessels formation. Show impair callosal axons to cross the midline during cortical development. Show disruption of all three midline commissure fibers crossing, the corpus callosum, the anterior commissure and the dorsal hippocampal commissure during cortical develpoment. Conditional knockout mice in which rapgef2 is lacking within the dorsal telencephalon result in malformation of the cortical brain structures: developed an ectopic cortical mass (ECM) extending throughout the rostro-caudal axis of the cerebral hemisphere. Mice show also an enlargement of the lateral ventricles and the agenesis of interhemispheric connections: the corpus callosum, the dorsal hippocampus commissure and the anterior commissure (PubMed:19453629). Belongs to the RAPGEF2 family. blood vessel development neuron migration guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity GTPase activator activity cytoplasm endosome late endosome cytosol plasma membrane cell-cell junction bicellular tight junction signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway small GTPase mediated signal transduction multicellular organism development nervous system development negative regulation of cell proliferation positive regulation of neuron projection development membrane apical plasma membrane Rap guanyl-nucleotide exchange factor activity protein kinase binding cAMP-mediated signaling ventricular system development forebrain neuron development microvillus assembly cell junction endocytic vesicle cell differentiation PDZ domain binding cAMP binding neuron projection development brain-derived neurotrophic factor receptor signaling pathway beta-1 adrenergic receptor binding positive regulation of protein binding Rap protein signal transduction macromolecular complex nerve growth factor signaling pathway regulation of cell proliferation neuron projection neuronal cell body positive regulation of GTPase activity positive regulation of cAMP-mediated signaling synapse positive regulation of protein kinase activity negative regulation of melanin biosynthetic process regulation of synaptic plasticity perinuclear region of cytoplasm WW domain binding negative regulation of dendrite morphogenesis establishment of endothelial barrier phosphatidic acid binding positive regulation of ERK1 and ERK2 cascade cellular response to cAMP cellular response to cGMP adenylate cyclase-activating adrenergic receptor signaling pathway protein localization to plasma membrane establishment of endothelial intestinal barrier regulation of cell junction assembly cellular response to nerve growth factor stimulus positive regulation of cAMP-dependent protein kinase activity positive regulation of dendritic cell apoptotic process positive regulation of vasculogenesis positive regulation of neuron migration uc290gas.1 uc290gas.2 
ENSMUST00000118108.2 Rabepk ENSMUST00000118108.2 Rab9 effector protein with kelch motifs, transcript variant 2 (from RefSeq NM_001374669.1) B0R0S4 B0R0S4_MOUSE ENSMUST00000118108.1 NM_001374669 Rabepk uc289vju.1 uc289vju.2 Rab9 effector required for endosome to trans-Golgi network (TGN) transport. uc289vju.1 uc289vju.2 
ENSMUST00000118139.3 Glt1d1 ENSMUST00000118139.3 glycosyltransferase 1 domain containing 1 (from RefSeq NM_177005.4) A4FUP9 ENSMUST00000118139.1 ENSMUST00000118139.2 GL1D1_MOUSE NM_177005 Q8BWP4 uc008zsd.1 uc008zsd.2 uc008zsd.3 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A4FUP9-1; Sequence=Displayed; Name=2; IsoId=A4FUP9-2; Sequence=VSP_029734, VSP_029735; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. molecular_function extracellular region cytosol biological_process transferase activity transferase activity, transferring glycosyl groups uc008zsd.1 uc008zsd.2 uc008zsd.3 
ENSMUST00000118152.8 Cbx5 ENSMUST00000118152.8 chromobox 5, transcript variant 4 (from RefSeq NM_001358950.1) CBX5_MOUSE ENSMUST00000118152.1 ENSMUST00000118152.2 ENSMUST00000118152.3 ENSMUST00000118152.4 ENSMUST00000118152.5 ENSMUST00000118152.6 ENSMUST00000118152.7 Hp1a NM_001358950 Q61686 Q9CS35 Q9CXD1 uc007xxn.1 uc007xxn.2 uc007xxn.3 Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity). Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100 and STAM2 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys- 9'. Interacts with BAHD1, SETDB1, MIS12 and DSN1. Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete for interaction with CBX5. Interacts with INCENP. Interacts with CHAMP1 (By similarity). Interacts directly with TRIM28 via the chromoshadow domain (PubMed:8978696). Interacts with KMT5B and KMT5C (PubMed:15145825). Interacts with HP1BP3 and TRIM24 (PubMed:8978696). Interacts with PRR14 (via N-terminus) (By similarity). Interacts with RRP1B (By similarity). Interacts with HNRNPU (via C-terminus); this interaction is, at least in part, RNA-dependent (By similarity). Interacts with LRIF1 (via PxVxL motif) (By similarity). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (By similarity). May form homodimers (PubMed:8978696). Interacts with SMYD5 (PubMed:28250819). Interacts with CHD3 (By similarity). Interacts with CHD4 (By similarity). Q61686; Q8BUH8: Senp7; NbExp=4; IntAct=EBI-307973, EBI-15972382; Q61686; Q64127: Trim24; NbExp=4; IntAct=EBI-307973, EBI-307947; Nucleus Chromosome Chromosome, centromere Note=Colocalizes with HNRNPU in the nucleus (By similarity). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. Localizes to sites of DNA damage. Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. Ubiquitinated. histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter chromosome, centromeric region kinetochore nuclear chromosome, telomeric region heterochromatin chromatin binding protein binding nucleus nucleoplasm chromosome nuclear heterochromatin pericentric heterochromatin nucleolus cellular response to DNA damage stimulus chromocenter PML body transcriptional repressor complex protein binding, bridging macromolecular complex methylated histone binding histone methyltransferase complex identical protein binding protein homodimerization activity histone deacetylase binding ribonucleoprotein complex binding macromolecular complex binding negative regulation of transcription, DNA-templated repressing transcription factor binding ribonucleoprotein complex uc007xxn.1 uc007xxn.2 uc007xxn.3 
ENSMUST00000118157.8 Ankrd42 ENSMUST00000118157.8 ankyrin repeat domain 42, transcript variant 5 (from RefSeq NR_176432.1) A0A0R4J1P5 A0A0R4J1P5_MOUSE Ankrd42 ENSMUST00000118157.1 ENSMUST00000118157.2 ENSMUST00000118157.3 ENSMUST00000118157.4 ENSMUST00000118157.5 ENSMUST00000118157.6 ENSMUST00000118157.7 NR_176432 uc009ihz.1 uc009ihz.2 uc009ihz.3 uc009ihz.1 uc009ihz.2 uc009ihz.3 
ENSMUST00000118160.8 Rtkn2 ENSMUST00000118160.8 rhotekin 2, transcript variant 1 (from RefSeq NM_001359318.1) ENSMUST00000118160.1 ENSMUST00000118160.2 ENSMUST00000118160.3 ENSMUST00000118160.4 ENSMUST00000118160.5 ENSMUST00000118160.6 ENSMUST00000118160.7 NM_001359318 Plekhk1 Q14B46 Q8BFP3 Q8BFP8 Q8BFQ0 RTKN2_MOUSE uc011xfq.1 uc011xfq.2 uc011xfq.3 May play an important role in lymphopoiesis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14B46-1; Sequence=Displayed; Name=2; IsoId=Q14B46-2; Sequence=VSP_029140; molecular_function nucleus cytoplasm plasma membrane signal transduction positive regulation of cell proliferation hemopoiesis positive regulation of NF-kappaB transcription factor activity positive regulation of NIK/NF-kappaB signaling negative regulation of intrinsic apoptotic signaling pathway uc011xfq.1 uc011xfq.2 uc011xfq.3 
ENSMUST00000118161.3 Grm4 ENSMUST00000118161.3 glutamate receptor, metabotropic 4, transcript variant 1 (from RefSeq NM_001291045.2) ENSMUST00000118161.1 ENSMUST00000118161.2 G3XA00 G3XA00_MOUSE Grm4 NM_001291045 uc008box.1 uc008box.2 uc008box.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 3 family. activation of MAPK activity G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway glutamate receptor activity membrane integral component of membrane cytoplasmic vesicle positive regulation of MAPK cascade uc008box.1 uc008box.2 uc008box.3 
ENSMUST00000118163.8 Dmxl2 ENSMUST00000118163.8 Dmx-like 2 (from RefSeq NM_172771.2) B0V2P5 B0V2P5_MOUSE Dmxl2 ENSMUST00000118163.1 ENSMUST00000118163.2 ENSMUST00000118163.3 ENSMUST00000118163.4 ENSMUST00000118163.5 ENSMUST00000118163.6 ENSMUST00000118163.7 NM_172771 uc009pra.1 uc009pra.2 uc009pra.3 synaptic vesicle Rab GTPase binding uc009pra.1 uc009pra.2 uc009pra.3 
ENSMUST00000118169.8 Slc5a2 ENSMUST00000118169.8 solute carrier family 5 (sodium/glucose cotransporter), member 2 (from RefSeq NM_133254.5) ENSMUST00000118169.1 ENSMUST00000118169.2 ENSMUST00000118169.3 ENSMUST00000118169.4 ENSMUST00000118169.5 ENSMUST00000118169.6 ENSMUST00000118169.7 NM_133254 Q923I7 SC5A2_MOUSE Sglt2 uc009jyu.1 uc009jyu.2 uc009jyu.3 Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (By similarity). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (PubMed:20616166). Reaction=D-glucose(out) + Na(+)(out) = D-glucose(in) + Na(+)(in); Xref=Rhea:RHEA:70571, ChEBI:CHEBI:4167, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70572; Evidence=; Forms a heterodimer with PDZK1IP1; this interaction enhances the transporter activity over a hundred-fold. Apical cell membrane ; Multi-pass membrane protein Expressed in epithelial cells of early proximal tubules (at protein level). Mutant mice develop glucosuria associated with increased food and fluid intake. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. glucose:sodium symporter activity protein binding plasma membrane ion transport sodium ion transport carbohydrate transport symporter activity membrane integral component of membrane transmembrane transporter activity brush border membrane negative regulation of urine volume renal potassium excretion transmembrane transport glucose transmembrane transport uc009jyu.1 uc009jyu.2 uc009jyu.3 
ENSMUST00000118174.8 Phtf2 ENSMUST00000118174.8 putative homeodomain transcription factor 2 (from RefSeq NM_172992.3) A0A0R4J1Q1 A0A0R4J1Q1_MOUSE ENSMUST00000118174.1 ENSMUST00000118174.2 ENSMUST00000118174.3 ENSMUST00000118174.4 ENSMUST00000118174.5 ENSMUST00000118174.6 ENSMUST00000118174.7 NM_172992 Phtf2 uc008wnz.1 uc008wnz.2 uc008wnz.3 uc008wnz.4 Membrane ; Multi- pass membrane protein DNA binding endoplasmic reticulum membrane integral component of membrane uc008wnz.1 uc008wnz.2 uc008wnz.3 uc008wnz.4 
ENSMUST00000118193.8 Ttc33 ENSMUST00000118193.8 tetratricopeptide repeat domain 33, transcript variant 2 (from RefSeq NM_001355620.1) ENSMUST00000118193.1 ENSMUST00000118193.2 ENSMUST00000118193.3 ENSMUST00000118193.4 ENSMUST00000118193.5 ENSMUST00000118193.6 ENSMUST00000118193.7 NM_001355620 Q8VIG5 Q9D6K7 TTC33_MOUSE uc007vcv.1 uc007vcv.2 uc007vcv.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D6K7-1; Sequence=Displayed; Name=2; IsoId=Q9D6K7-2; Sequence=VSP_025532, VSP_025533; molecular_function cellular_component biological_process uc007vcv.1 uc007vcv.2 uc007vcv.3 
ENSMUST00000118198.8 Gtf2a2 ENSMUST00000118198.8 general transcription factor II A, 2, transcript variant 2 (from RefSeq NM_001039519.2) ENSMUST00000118198.1 ENSMUST00000118198.2 ENSMUST00000118198.3 ENSMUST00000118198.4 ENSMUST00000118198.5 ENSMUST00000118198.6 ENSMUST00000118198.7 NM_001039519 Q80ZM7 T2AG_MOUSE uc009qnr.1 uc009qnr.2 uc009qnr.3 uc009qnr.4 TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity). TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). Interacts with NCOA6 general coactivator. TFIIA forms a complex with TBP. Interacts with HSF1 (via transactivation domain). Interacts with HSF1 (via transactivation domain). Interacts with HSF1 (via transactivation domain). Nucleus Belongs to the TFIIA subunit 2 family. Sequence=AAH48705.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; RNA polymerase II repressing transcription factor binding transcription coactivator activity nucleus nucleoplasm transcription factor TFIID complex transcription factor TFIIA complex transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter transcription factor binding obsolete general RNA polymerase II transcription factor activity TBP-class protein binding cell junction protein homodimerization activity positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity positive regulation of sequence-specific DNA binding transcription factor activity RNA polymerase II transcriptional preinitiation complex assembly uc009qnr.1 uc009qnr.2 uc009qnr.3 uc009qnr.4 
ENSMUST00000118199.8 Pef1 ENSMUST00000118199.8 Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification. Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium. Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (By similarity). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (By similarity). (from UniProt Q8BFY6) AK075978 ENSMUST00000118199.1 ENSMUST00000118199.2 ENSMUST00000118199.3 ENSMUST00000118199.4 ENSMUST00000118199.5 ENSMUST00000118199.6 ENSMUST00000118199.7 PEF1_MOUSE Pef1 Q8BFY6 Q8VCT5 Q9CYW8 Q9D934 uc290qgf.1 uc290qgf.2 Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification. Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium. Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (By similarity). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (By similarity). Heterodimer; heterodimerizes (via the EF-hand 5) with PDCD6. Dissociates from PDCD6 in presence of calcium. Cytoplasm Endoplasmic reticulum Membrane ; Peripheral membrane protein Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein Note=Membrane-associated in the presence of Ca(2+) (By similarity). Localizes to endoplasmic reticulum exit site (ERES) (By similarity). Ubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex. Sequence=BAB28735.1; Type=Frameshift; Evidence=; Golgi membrane calcium ion binding cytoplasm endoplasmic reticulum ER to Golgi vesicle-mediated transport ER to Golgi transport vesicle membrane neural crest formation neural crest cell development membrane COPII vesicle coat cytoplasmic vesicle Cul3-RING ubiquitin ligase complex metal ion binding protein heterodimerization activity protein dimerization activity COPII vesicle coating calcium-dependent protein binding response to calcium ion binding, bridging positive regulation of protein monoubiquitination uc290qgf.1 uc290qgf.2 
ENSMUST00000118207.8 Tex35 ENSMUST00000118207.8 testis expressed 35, transcript variant 1 (from RefSeq NM_028540.3) A0A0R4J1P6 A0A0R4J1P6_MOUSE ENSMUST00000118207.1 ENSMUST00000118207.2 ENSMUST00000118207.3 ENSMUST00000118207.4 ENSMUST00000118207.5 ENSMUST00000118207.6 ENSMUST00000118207.7 NM_028540 Tex35 uc007ddf.1 uc007ddf.2 uc007ddf.3 uc007ddf.4 microtubule cytoskeleton uc007ddf.1 uc007ddf.2 uc007ddf.3 uc007ddf.4 
ENSMUST00000118209.8 Atp5pb ENSMUST00000118209.8 ATP synthase peripheral stalk-membrane subunit b, transcript variant 1 (from RefSeq NM_009725.5) AT5F1_MOUSE Atp5f1 Atp5pb ENSMUST00000118209.1 ENSMUST00000118209.2 ENSMUST00000118209.3 ENSMUST00000118209.4 ENSMUST00000118209.5 ENSMUST00000118209.6 ENSMUST00000118209.7 NM_009725 Q9CQQ7 uc290ill.1 uc290ill.2 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT- ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). Mitochondrion. Mitochondrion inner membrane. Belongs to the eukaryotic ATPase B chain family. mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) nucleoplasm mitochondrion mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex ion transport hydrogen ion transmembrane transporter activity ATP synthesis coupled proton transport membrane ATPase activity myelin sheath macromolecular complex binding proton-transporting ATP synthase complex, coupling factor F(o) proton-transporting ATP synthase activity, rotational mechanism uc290ill.1 uc290ill.2 
ENSMUST00000118216.8 Acp4 ENSMUST00000118216.8 acid phosphatase 4, transcript variant 1 (from RefSeq NM_001195034.1) Acp4 Acpt D3YTS9 ENSMUST00000118216.1 ENSMUST00000118216.2 ENSMUST00000118216.3 ENSMUST00000118216.4 ENSMUST00000118216.5 ENSMUST00000118216.6 ENSMUST00000118216.7 NM_001195034 PPAT_MOUSE uc012fjn.1 uc012fjn.2 uc012fjn.3 May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis. Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2; Homodimer. Membrane ; Single-pass membrane protein In the developing tooth from 8-day-old mice it is expressed in secretory-stage ameloblasts, follicular cells, odontoblasts, and osteoblasts (at protein level). Glycosylated. Belongs to the histidine acid phosphatase family. acid phosphatase activity protein tyrosine phosphatase activity cellular_component negative regulation of protein processing negative regulation of neuron projection development membrane integral component of membrane hydrolase activity receptor tyrosine kinase binding odontogenesis postsynaptic membrane regulation of neuronal synaptic plasticity peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity uc012fjn.1 uc012fjn.2 uc012fjn.3 
ENSMUST00000118218.8 Dmrtc1c1 ENSMUST00000118218.8 DMRT-like family C1c1, transcript variant 2 (from RefSeq NM_001359628.1) Dmrtc1c1 Dmrtc1c2 ENSMUST00000118218.1 ENSMUST00000118218.2 ENSMUST00000118218.3 ENSMUST00000118218.4 ENSMUST00000118218.5 ENSMUST00000118218.6 ENSMUST00000118218.7 NM_001359628 Q9D410 Q9D410_MOUSE uc009tyx.1 uc009tyx.2 uc009tyx.3 uc009tyx.4 Belongs to the DMRT family. molecular_function transcription factor activity, sequence-specific DNA binding cellular_component nucleus regulation of transcription, DNA-templated biological_process uc009tyx.1 uc009tyx.2 uc009tyx.3 uc009tyx.4 
ENSMUST00000118254.2 Pate2 ENSMUST00000118254.2 prostate and testis expressed 2 (from RefSeq NM_001033421.3) ENSMUST00000118254.1 Gm846 NM_001033421 PATE2_MOUSE Q3UMN1 Q3UW31 uc009otl.1 uc009otl.2 uc009otl.3 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UW31-1; Sequence=Displayed; Name=2; IsoId=Q3UW31-2; Sequence=VSP_021874; Expressed in prostate, testis, brain and lung. Belongs to the PATE family. molecular_function extracellular region extracellular space biological_process uc009otl.1 uc009otl.2 uc009otl.3 
ENSMUST00000118278.2 Cyp4a29 ENSMUST00000118278.2 cytochrome P450, family 4, subfamily a, polypeptide 29 (from RefSeq NM_001100183.2) A0A087WPC3 A0A087WPC3_MOUSE Cyp4a29 ENSMUST00000118278.1 NM_001100183 uc008ueq.1 uc008ueq.2 Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc008ueq.1 uc008ueq.2 
ENSMUST00000118287.9 Prpf40b ENSMUST00000118287.9 pre-mRNA processing factor 40B, transcript variant 6 (from RefSeq NM_001370635.1) E9QP07 E9QP07_MOUSE ENSMUST00000118287.1 ENSMUST00000118287.2 ENSMUST00000118287.3 ENSMUST00000118287.4 ENSMUST00000118287.5 ENSMUST00000118287.6 ENSMUST00000118287.7 ENSMUST00000118287.8 NM_001370635 Prpf40b uc289bfh.1 uc289bfh.2 mRNA cis splicing, via spliceosome uc289bfh.1 uc289bfh.2 
ENSMUST00000118294.8 Hdac7 ENSMUST00000118294.8 histone deacetylase 7, transcript variant 2 (from RefSeq NM_001204276.1) ENSMUST00000118294.1 ENSMUST00000118294.2 ENSMUST00000118294.3 ENSMUST00000118294.4 ENSMUST00000118294.5 ENSMUST00000118294.6 ENSMUST00000118294.7 HDAC7_MOUSE Hdac7a NM_001204276 Q8C2B3 Q8C2C9 Q8C8X4 Q8CB80 Q8CDA3 Q9JL72 uc007xlf.1 uc007xlf.2 uc007xlf.3 uc007xlf.4 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Positively regulates the transcriptional repressor activity of FOXP3 (By similarity). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity). Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA- COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; Interacts with KDM5B (By similarity). Interacts with KAT5 and EDNRA. Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C. Interacts with ZMYND15. Interacts with PML (By similarity). Interacts with FOXP3. Interacts with RARA (By similarity). Q8C2B3; P62259: Ywhae; NbExp=5; IntAct=EBI-643830, EBI-356480; Q8C2B3-1; Q15139: PRKD1; Xeno; NbExp=3; IntAct=EBI-15705168, EBI-1181072; Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8C2B3-1; Sequence=Displayed; Name=2; IsoId=Q8C2B3-2; Sequence=VSP_007432, VSP_007434, VSP_007435; Name=3; IsoId=Q8C2B3-3; Sequence=VSP_007432, VSP_007434; Name=4; IsoId=Q8C2B3-4; Sequence=VSP_007433, VSP_007434, VSP_007435; Name=5; IsoId=Q8C2B3-5; Sequence=VSP_007432; Name=6; IsoId=Q8C2B3-6; Sequence=VSP_007433; Highly expressed in heart and lung. Expressed at intermediate level in muscle. The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm. May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-178 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-178 is a prerequisite for phosphorylation at Ser-204 (By similarity). Its activity is inhibited by Trichostatin A (TSA), a known histone deacetylase inhibitor. Belongs to the histone deacetylase family. HD type 2 subfamily. histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter vasculogenesis chromatin binding transcription corepressor activity histone deacetylase activity protein kinase C binding protein binding nucleus cytoplasm cytosol chromatin organization inflammatory response cell-cell junction assembly nervous system development transcription factor binding histone deacetylation hydrolase activity protein kinase binding B cell differentiation NAD-dependent histone deacetylase activity (H3-K14 specific) negative regulation of interleukin-2 production activating transcription factor binding B cell activation negative regulation of osteoblast differentiation negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated metal ion binding repressing transcription factor binding histone H3 deacetylation 14-3-3 protein binding positive regulation of cell migration involved in sprouting angiogenesis negative regulation of neuron death negative regulation of NIK/NF-kappaB signaling uc007xlf.1 uc007xlf.2 uc007xlf.3 uc007xlf.4 
ENSMUST00000118305.8 Magea13 ENSMUST00000118305.8 Magea13 (from geneSymbol) 4930550L24Rik BC087920 ENSMUST00000118305.1 ENSMUST00000118305.2 ENSMUST00000118305.3 ENSMUST00000118305.4 ENSMUST00000118305.5 ENSMUST00000118305.6 ENSMUST00000118305.7 Magea13 Q99PA7 Q99PA7_MOUSE uc033jqc.1 uc033jqc.2 uc033jqc.3 molecular_function biological_process uc033jqc.1 uc033jqc.2 uc033jqc.3 
ENSMUST00000118316.8 N4bp2l2 ENSMUST00000118316.8 NEDD4 binding protein 2-like 2, transcript variant 2 (from RefSeq NM_201369.3) ENSMUST00000118316.1 ENSMUST00000118316.2 ENSMUST00000118316.3 ENSMUST00000118316.4 ENSMUST00000118316.5 ENSMUST00000118316.6 ENSMUST00000118316.7 N42L2_MOUSE NM_201369 Pfaap5 Q8JZS6 uc012eho.1 uc012eho.2 uc012eho.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8JZS6-1; Sequence=Displayed; Name=2; IsoId=Q8JZS6-2; Sequence=VSP_027519, VSP_027520; [Isoform 2]: Due to a partial intron retention. negative regulation of transcription from RNA polymerase II promoter in utero embryonic development blastocyst development transcription corepressor activity protein binding nucleus transcriptional repressor complex enzyme binding positive regulation of hematopoietic stem cell proliferation negative regulation of hematopoietic stem cell differentiation uc012eho.1 uc012eho.2 uc012eho.3 
ENSMUST00000118317.8 Hipk1 ENSMUST00000118317.8 homeodomain interacting protein kinase 1, transcript variant 2 (from RefSeq NM_001301304.1) A6H5Z7 ENSMUST00000118317.1 ENSMUST00000118317.2 ENSMUST00000118317.3 ENSMUST00000118317.4 ENSMUST00000118317.5 ENSMUST00000118317.6 ENSMUST00000118317.7 HIPK1_MOUSE Kiaa0630 Myak NM_001301304 Nbak2 O88904 Q80TV5 Q9QUQ8 Q9QZR3 Q9WVN7 uc008qti.1 uc008qti.2 uc008qti.3 Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts with Nkx1-2, Nkx2-5, MYB, PARK7, DAXX and p53/TP53. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis. O88904; O35613: Daxx; NbExp=3; IntAct=EBI-692945, EBI-77304; O88904; P23804: Mdm2; NbExp=3; IntAct=EBI-692945, EBI-641788; O88904; Q5EBH1: Rassf5; NbExp=5; IntAct=EBI-692945, EBI-960530; O88904; Q9UER7: DAXX; Xeno; NbExp=3; IntAct=EBI-692945, EBI-77321; Nucleus toplasm cleus speckle Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1- mediated desumoylation. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=2b, Myak-L; IsoId=O88904-1; Sequence=Displayed; Name=2; Synonyms=2a; IsoId=O88904-2; Sequence=VSP_013133; Name=3; Synonyms=Myak-S; IsoId=O88904-3; Sequence=VSP_013132, VSP_013134; Ubiquitously expressed, with high levels in reproductive tissues. Expressed in the epithelial layer of mammary gland, uterus and epididymis, in the corpus luteum, and in post-meiotic round spermatids. Highest at 12 dpc, where it is expressed primarily in the central nervous system. Highly induced during primary fetal liver erythropoiesis. Expressed in the inner retina during late embryogenesis, predominantly in cytoplasm. Phosphorylated and activated by JNK1 (By similarity). Autophosphorylated. Sumoylated. When conjugated it is directed to nuclear speckles. SENP1-mediated desumoylation is mediated by TNF in response to stress stimuli, triggering transient translocation from nucleus to cytoplasm. Small eyes with deficient lens, abnormal retinal lamination, and thickened retinas. [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. negative regulation of transcription from RNA polymerase II promoter nucleotide binding transcription corepressor activity protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm centrosome cytosol protein phosphorylation smoothened signaling pathway positive regulation of cell proliferation anterior/posterior pattern specification regulation of tumor necrosis factor-mediated signaling pathway retina layer formation kinase activity phosphorylation PML body nuclear speck transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation neuron differentiation adherens junction assembly intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of DNA binding embryonic camera-type eye morphogenesis embryonic retina morphogenesis in camera-type eye lens induction in camera-type eye iris morphogenesis endothelial cell apoptotic process extrinsic apoptotic signaling pathway DNA binding uc008qti.1 uc008qti.2 uc008qti.3 
ENSMUST00000118336.4 Or1e28-ps1 ENSMUST00000118336.4 Or1e28-ps1 (from geneSymbol) ENSMUST00000118336.1 ENSMUST00000118336.2 ENSMUST00000118336.3 uc287zzy.1 uc287zzy.2 uc287zzy.1 uc287zzy.2 
ENSMUST00000118360.8 Kcnd3 ENSMUST00000118360.8 Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. (from UniProt Q9Z0V1) AK147574 ENSMUST00000118360.1 ENSMUST00000118360.2 ENSMUST00000118360.3 ENSMUST00000118360.4 ENSMUST00000118360.5 ENSMUST00000118360.6 ENSMUST00000118360.7 KCND3_MOUSE Q8CC44 Q9Z0V0 Q9Z0V1 uc290iko.1 uc290iko.2 Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Homotetramer or heterotetramer with KCND1 and/or KCND2. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Interacts with DLG1, KCNE1, KCNE2, SCN1B and KCNAB1 (By similarity). Cell membrane ; Multi-pass membrane protein Cell membrane, sarcolemma ; Multi-pass membrane protein Cell projection, dendrite Note=Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Kv4.3L; IsoId=Q9Z0V1-1; Sequence=Displayed; Name=2; Synonyms=Kv4.3M; IsoId=Q9Z0V1-2; Sequence=VSP_008827; Name=3; IsoId=Q9Z0V1-3; Sequence=VSP_008828, VSP_008829; The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Regulated through phosphorylation at Ser-569 by CaMK2D. [Isoform 3]: May be due to intron retention. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity A-type (transient outward) potassium channel activity potassium channel activity protein binding plasma membrane integral component of plasma membrane caveola ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane dendrite potassium channel complex regulation of ion transmembrane transport sarcolemma cell projection neuron projection neuronal cell body ion channel binding metal ion binding protein homooligomerization transmembrane transport cellular response to BMP stimulus potassium ion transmembrane transport membrane repolarization regulation of heart rate by cardiac conduction perinuclear endoplasmic reticulum potassium ion export across plasma membrane membrane repolarization during ventricular cardiac muscle cell action potential GABA-ergic synapse integral component of postsynaptic specialization membrane ventricular cardiac muscle cell membrane repolarization voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization potassium ion import across plasma membrane uc290iko.1 uc290iko.2 
ENSMUST00000118364.2 Il23r ENSMUST00000118364.2 interleukin 23 receptor (from RefSeq NM_144548.2) ENSMUST00000118364.1 IL23R_MOUSE NM_144548 Q8K4B4 uc009cfp.1 uc009cfp.2 Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis (By similarity). Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3 (By similarity). Cell membrane ; Single-pass type I membrane protein Expressed by Th1, Th2 and dendritic cells. Phosphorylated in response to IL23. Belongs to the type I cytokine receptor family. Type 2 subfamily. positive regulation of defense response to virus by host immune system process leukocyte mediated immunity positive regulation of T-helper 1 type immune response cytokine receptor activity plasma membrane integral component of plasma membrane inflammatory response JAK-STAT cascade external side of plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway cytokine binding response to lipopolysaccharide negative regulation of interleukin-10 production positive regulation of interferon-gamma production positive regulation of interleukin-12 production response to interferon-gamma interleukin-23-mediated signaling pathway interleukin-23 binding interleukin-23 receptor activity receptor complex innate immune response interleukin-23 receptor complex interleukin-12 receptor binding uc009cfp.1 uc009cfp.2 
ENSMUST00000118365.3 Card6 ENSMUST00000118365.3 caspase recruitment domain family, member 6 (from RefSeq NM_001163138.1) Card6 E9PWH2 E9PWH2_MOUSE ENSMUST00000118365.1 ENSMUST00000118365.2 NM_001163138 uc007vcr.1 uc007vcr.2 uc007vcr.3 uc007vcr.4 molecular_function cytoplasm regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling uc007vcr.1 uc007vcr.2 uc007vcr.3 uc007vcr.4 
ENSMUST00000118367.3 Psg16 ENSMUST00000118367.3 pregnancy specific beta-1-glycoprotein 16, transcript variant 2 (from RefSeq NM_007676.4) D0VY58 D0VY58_MOUSE ENSMUST00000118367.1 ENSMUST00000118367.2 NM_007676 PSG Psg16 uc009veh.1 uc009veh.2 uc009veh.3 molecular_function female pregnancy biological_process cell surface uc009veh.1 uc009veh.2 uc009veh.3 
ENSMUST00000118370.8 Nod2 ENSMUST00000118370.8 nucleotide-binding oligomerization domain containing 2 (from RefSeq NM_145857.2) Card15 ENSMUST00000118370.1 ENSMUST00000118370.2 ENSMUST00000118370.3 ENSMUST00000118370.4 ENSMUST00000118370.5 ENSMUST00000118370.6 ENSMUST00000118370.7 NM_145857 Nod2 Q80SY9 Q80SY9_MOUSE uc009mrr.1 uc009mrr.2 uc009mrr.3 Basolateral cell membrane Cell membrane ; Lipid-anchor Cytoplasm Lateral cell membrane Membrane ; Lipid-anchor Belongs to the NOD1-NOD2 family. nucleotide binding cytokine production involved in immune response cytokine secretion involved in immune response positive regulation of dendritic cell cytokine production positive regulation of type 2 immune response actin binding protein binding ATP binding cytoplasm Golgi apparatus cytosol cytoskeleton plasma membrane DNA metabolic process response to nutrient positive regulation of cell proliferation cell surface detection of bacterium basolateral plasma membrane endodeoxyribonuclease activity, producing 5'-phosphomonoesters enzyme binding protein kinase binding maintenance of gastrointestinal epithelium Hsp70 protein binding vesicle response to muramyl dipeptide detection of muramyl dipeptide muramyl dipeptide binding positive regulation of interleukin-1 beta production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade macromolecular complex intracellular signal transduction defense response to bacterium peptidoglycan binding regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling macromolecular complex binding innate immune response positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade CARD domain binding positive regulation of interleukin-1 beta secretion positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity Hsp90 protein binding nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to lipopolysaccharide cellular response to peptidoglycan cellular response to muramyl dipeptide cellular response to organic cyclic compound positive regulation of cytokine production involved in inflammatory response positive regulation of NIK/NF-kappaB signaling positive regulation of protein K63-linked ubiquitination uc009mrr.1 uc009mrr.2 uc009mrr.3 
ENSMUST00000118374.8 R3hcc1 ENSMUST00000118374.8 R3H domain and coiled-coil containing 1, transcript variant 2 (from RefSeq NM_001146012.2) ENSMUST00000118374.1 ENSMUST00000118374.2 ENSMUST00000118374.3 ENSMUST00000118374.4 ENSMUST00000118374.5 ENSMUST00000118374.6 ENSMUST00000118374.7 NM_001146012 Q8BSI6 R3HC1_MOUSE R3hcc1 uc007umq.1 uc007umq.2 uc007umq.3 uc007umq.4 uc007umq.5 uc007umq.6 Ribosome profiling data indicate that translation initiates from the non-AUG (CUG) codon used here. Sequence=BAC28055.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE33872.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleic acid binding biological_process exon-exon junction complex uc007umq.1 uc007umq.2 uc007umq.3 uc007umq.4 uc007umq.5 uc007umq.6 
ENSMUST00000118375.8 Tbkbp1 ENSMUST00000118375.8 TBK1 binding protein 1, transcript variant 1 (from RefSeq NM_198100.3) ENSMUST00000118375.1 ENSMUST00000118375.2 ENSMUST00000118375.3 ENSMUST00000118375.4 ENSMUST00000118375.5 ENSMUST00000118375.6 ENSMUST00000118375.7 NM_198100 Tbkbp1 Z4YKN2 Z4YKN2_MOUSE uc288bto.1 uc288bto.2 uc288bto.1 uc288bto.2 
ENSMUST00000118378.2 Or51l1-ps1 ENSMUST00000118378.2 Or51l1-ps1 (from geneSymbol) ENSMUST00000118378.1 NR_190761 uc291tpd.1 uc291tpd.2 uc291tpd.1 uc291tpd.2 
ENSMUST00000118383.8 Slc7a9 ENSMUST00000118383.8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9, transcript variant 2 (from RefSeq NM_001199015.1) BAT1_MOUSE Bat1 ENSMUST00000118383.1 ENSMUST00000118383.2 ENSMUST00000118383.3 ENSMUST00000118383.4 ENSMUST00000118383.5 ENSMUST00000118383.6 ENSMUST00000118383.7 NM_001199015 Q9QXA6 uc009gjw.1 uc009gjw.2 uc009gjw.3 uc009gjw.4 Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (PubMed:10588648) (By similarity). Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (By similarity). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L- cysteine (By similarity). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules (By similarity). Reaction=L-arginine(in) + L-leucine(out) = L-arginine(out) + L- leucine(in); Xref=Rhea:RHEA:71059, ChEBI:CHEBI:32682, ChEBI:CHEBI:57427; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71060; Evidence=; Reaction=L-arginine(in) + L-histidine(out) = L-arginine(out) + L- histidine(in); Xref=Rhea:RHEA:71063, ChEBI:CHEBI:32682, ChEBI:CHEBI:57595; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71064; Evidence=; Reaction=L-arginine(in) + L-phenylalanine(out) = L-arginine(out) + L- phenylalanine(in); Xref=Rhea:RHEA:71067, ChEBI:CHEBI:32682, ChEBI:CHEBI:58095; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71068; Evidence=; Reaction=L-arginine(in) + L-cysteine(out) = L-arginine(out) + L- cysteine(in); Xref=Rhea:RHEA:71071, ChEBI:CHEBI:32682, ChEBI:CHEBI:35235; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71072; Evidence=; Reaction=L-arginine(in) + L-cystine(out) = L-arginine(out) + L- cystine(in); Xref=Rhea:RHEA:71075, ChEBI:CHEBI:32682, ChEBI:CHEBI:35491; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71076; Evidence=; Reaction=L-arginine(in) + L-lysine(out) = L-arginine(out) + L- lysine(in); Xref=Rhea:RHEA:70827, ChEBI:CHEBI:32551, ChEBI:CHEBI:32682; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70828; Evidence=; Disulfide-linked heterodimer composed of the catalytic light chain subunit SLC7A9 and the heavy chain subunit SLC3A1. The heterodimer is the minimal functional unit. Assembles in heterotetramers (dimers of heterodimers) and higher order oligomers; the oligomerization is mediated by SLC3A1 likely to prevent degradation and facilitate heteromer trafficking to the plasma membrane (By similarity) (PubMed:10588648). Interacts with CAV1 (By similarity). Apical cell membrane ; Multi-pass membrane protein Expressed in the brush border membrane in the kidney (at protein level). Belongs to the amino acid-polyamine-organocation (APC) superfamily. amino acid transmembrane transport protein binding plasma membrane amino acid transport amino acid transmembrane transporter activity neutral amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity L-cystine transmembrane transporter activity neutral amino acid transport L-cystine transport membrane integral component of membrane apical plasma membrane transmembrane transporter activity brush border membrane peptide antigen binding transmembrane transport L-alpha-amino acid transmembrane transport uc009gjw.1 uc009gjw.2 uc009gjw.3 uc009gjw.4 
ENSMUST00000118408.8 Fhip1a ENSMUST00000118408.8 FHF complex subunit HOOK interacting protein 1A (from RefSeq NM_172682.3) ENSMUST00000118408.1 ENSMUST00000118408.2 ENSMUST00000118408.3 ENSMUST00000118408.4 ENSMUST00000118408.5 ENSMUST00000118408.6 ENSMUST00000118408.7 FHI1A_MOUSE Fam160a1 Fhip1a NM_172682 Q505K2 Q8BZ23 uc008pqw.1 uc008pqw.2 uc008pqw.3 uc008pqw.4 Probable component of the FTS/Hook/FHIP complex (FHF complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. May be a component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS. Belongs to the FHIP family. Sequence=BAC29618.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component biological_process uc008pqw.1 uc008pqw.2 uc008pqw.3 uc008pqw.4 
ENSMUST00000118411.2 Mab21l3 ENSMUST00000118411.2 Belongs to the mab-21 family. (from UniProt Q8CI17) AK166928 ENSMUST00000118411.1 MB213_MOUSE Mab21L3 Q3TKM3 Q8CE43 Q8CI17 uc057lgi.1 uc057lgi.2 uc057lgi.3 Belongs to the mab-21 family. It is uncertain whether Met-1 or Met-68 is the initiator. molecular_function cellular_component biological_process uc057lgi.1 uc057lgi.2 uc057lgi.3 
ENSMUST00000118413.3 Sh2d7 ENSMUST00000118413.3 SH2 domain containing 7 (from RefSeq NM_173778.4) ENSMUST00000118413.1 ENSMUST00000118413.2 NM_173778 Q8BI17 SH2D7_MOUSE uc009pre.1 uc009pre.2 uc009pre.3 uc009pre.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BI17-1; Sequence=Displayed; Name=2; IsoId=Q8BI17-2; Sequence=VSP_034233; Sequence=BAC26825.1; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm biological_process uc009pre.1 uc009pre.2 uc009pre.3 uc009pre.4 
ENSMUST00000118419.2 Adam5 ENSMUST00000118419.2 a disintegrin and metallopeptidase domain 5, transcript variant 3 (from RefSeq NM_007401.3) ADAM5_MOUSE Adam5 ENSMUST00000118419.1 NM_007401 Q3TTE0 Q3TTE2 Q52KQ5 Q60623 Q60816 Q8CDV5 Q9D4F0 Tmdc2 uc009lfg.1 uc009lfg.2 uc009lfg.3 uc009lfg.4 This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of related ADAM genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]. This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity). Interacts with TEX101. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3TTE0-1; Sequence=Displayed; Name=2; IsoId=Q3TTE0-2; Sequence=VSP_035338; Name=3; IsoId=Q3TTE0-3; Sequence=VSP_035334, VSP_035337; Name=4; IsoId=Q3TTE0-4; Sequence=VSP_035335, VSP_035336; Expressed in sperm (at protein level) (PubMed:20945367). Highly expressed in testis (PubMed:7750654). Expressed in the brain, kidney, liver, lung, spleen and ovary (PubMed:7750654). Subject to proteolytic processing during epididymal transit of spermatozoa. Not expected to have protease activity. metalloendopeptidase activity protein binding proteolysis metallopeptidase activity membrane integral component of membrane uc009lfg.1 uc009lfg.2 uc009lfg.3 uc009lfg.4 
ENSMUST00000118444.3 Lrp3 ENSMUST00000118444.3 low density lipoprotein receptor-related protein 3, transcript variant 2 (from RefSeq NM_001421534.1) E9Q711 E9Q711_MOUSE ENSMUST00000118444.1 ENSMUST00000118444.2 Lrp3 NM_001421534 uc291omj.1 uc291omj.2 Membrane, coated pit Belongs to the LDLR family. Lacks conserved residue(s) required for the propagation of feature annotation. protein binding cellular_component biological_process membrane integral component of membrane uc291omj.1 uc291omj.2 
ENSMUST00000118466.8 Prxl2a ENSMUST00000118466.8 peroxiredoxin like 2A, transcript variant 11 (from RefSeq NM_001378814.1) 5730469M10Rik ENSMUST00000118466.1 ENSMUST00000118466.2 ENSMUST00000118466.3 ENSMUST00000118466.4 ENSMUST00000118466.5 ENSMUST00000118466.6 ENSMUST00000118466.7 Fam213a NM_001378814 Prxl2a Q3U125 Q3U125_MOUSE uc007tcj.1 uc007tcj.2 uc007tcj.3 uc007tcj.4 Cytoplasm Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily. cytoplasm membrane integral component of membrane antioxidant activity regulation of osteoclast differentiation oxidation-reduction process cellular oxidant detoxification uc007tcj.1 uc007tcj.2 uc007tcj.3 uc007tcj.4 
ENSMUST00000118485.8 Megf11 ENSMUST00000118485.8 multiple EGF-like-domains 11, transcript variant 35 (from RefSeq NR_176784.1) ENSMUST00000118485.1 ENSMUST00000118485.2 ENSMUST00000118485.3 ENSMUST00000118485.4 ENSMUST00000118485.5 ENSMUST00000118485.6 ENSMUST00000118485.7 Kiaa1781 MEG11_MOUSE NR_176784 Q3TV46 Q80T91 Q8BKK7 Q8BX64 uc292icw.1 uc292icw.2 May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. Homomer. Does not interact with MEGF10. Cell membrane ; Single-pass type I membrane protein Basolateral cell membrane ; Single-pass type I membrane protein Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10 (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80T91-1; Sequence=Displayed; Name=2; IsoId=Q80T91-2; Sequence=VSP_029253, VSP_029255, VSP_029257, VSP_029258; Name=3; IsoId=Q80T91-3; Sequence=VSP_029254; Name=4; IsoId=Q80T91-4; Sequence=VSP_029256, VSP_029259; Belongs to the MEGF family. Sequence=BAC65837.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component plasma membrane retina layer formation membrane integral component of membrane basolateral plasma membrane homotypic cell-cell adhesion uc292icw.1 uc292icw.2 
ENSMUST00000118501.8 Pdcd5 ENSMUST00000118501.8 programmed cell death 5 (from RefSeq NM_019746.4) ENSMUST00000118501.1 ENSMUST00000118501.2 ENSMUST00000118501.3 ENSMUST00000118501.4 ENSMUST00000118501.5 ENSMUST00000118501.6 ENSMUST00000118501.7 NM_019746 Pdcd5 Q564F6 Q564F6_MOUSE uc009gkf.1 uc009gkf.2 uc009gkf.3 Belongs to the PDCD5 family. DNA binding nucleus heparin binding negative regulation of cell proliferation positive regulation of gene expression acetyltransferase activator activity positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process beta-tubulin binding cellular response to transforming growth factor beta stimulus positive regulation of release of cytochrome c from mitochondria positive regulation of protein import into mitochondrial outer membrane negative regulation of chaperone-mediated protein folding uc009gkf.1 uc009gkf.2 uc009gkf.3 
ENSMUST00000118522.8 Paxbp1 ENSMUST00000118522.8 PAX3 and PAX7 binding protein 1, transcript variant 2 (from RefSeq NR_152264.1) E9QNN9 ENSMUST00000118522.1 ENSMUST00000118522.2 ENSMUST00000118522.3 ENSMUST00000118522.4 ENSMUST00000118522.5 ENSMUST00000118522.6 ENSMUST00000118522.7 Gcfc Gcfc1 NR_152264 P58501 PAXB1_MOUSE Q78XY2 Q8R2W3 Q9CRB7 uc012aih.1 uc012aih.2 uc012aih.3 Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. Interacts with PAX3 and PAX7. Interacts with WDR5; associates with a histone methyltransferase (HMT) complex composed at least of RBBP5, ASH2L, SET1, SET2 and KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4 through direct interaction with WDR5. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A; IsoId=P58501-1; Sequence=Displayed; Name=2; Synonyms=D; IsoId=P58501-2; Sequence=VSP_004268, VSP_004269; Ubiquitously expressed in all tissues tested including skeletal muscle. Expressed in primary myoblasts. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the GCF family. Sequence=AAH14838.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; Sequence=AAH27145.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH27145.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; Sequence=BAB24988.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; Sequence=BAB27645.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated muscle organ development transcription factor binding regulation of skeletal muscle satellite cell proliferation positive regulation of histone methylation positive regulation of transcription from RNA polymerase II promoter positive regulation of myoblast proliferation uc012aih.1 uc012aih.2 uc012aih.3 
ENSMUST00000118525.9 Ankrd29 ENSMUST00000118525.9 ankyrin repeat domain 29, transcript variant 1 (from RefSeq NM_001190371.1) Ankrd29 D3YVV3 D3YVV3_MOUSE ENSMUST00000118525.1 ENSMUST00000118525.2 ENSMUST00000118525.3 ENSMUST00000118525.4 ENSMUST00000118525.5 ENSMUST00000118525.6 ENSMUST00000118525.7 ENSMUST00000118525.8 NM_001190371 uc008ecd.1 uc008ecd.2 uc008ecd.3 uc008ecd.4 molecular_function cellular_component biological_process uc008ecd.1 uc008ecd.2 uc008ecd.3 uc008ecd.4 
ENSMUST00000118527.8 Slc46a3 ENSMUST00000118527.8 solute carrier family 46, member 3, transcript variant 2 (from RefSeq NM_001357002.1) ENSMUST00000118527.1 ENSMUST00000118527.2 ENSMUST00000118527.3 ENSMUST00000118527.4 ENSMUST00000118527.5 ENSMUST00000118527.6 ENSMUST00000118527.7 NM_001357002 Q9DC26 S46A3_MOUSE uc009aom.1 uc009aom.2 uc009aom.3 Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm (By similarity). Modulates hepatic cytosolic copper homeostasis, maybe acting as a lysosomal copper transporter and sequestering copper ions in the lysosome (PubMed:33436590). Delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Selectively transports bacterial muramyl dipeptide (MDP) into the cytosol for recognition by NOD2, triggering inflammatory responses (PubMed:28539433, PubMed:37116499). Likely acts as a redundant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages (PubMed:34235268). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable). Reaction=estrone 3-sulfate(out) + n H(+)(out) = estrone 3-sulfate(in) + n H(+)(in); Xref=Rhea:RHEA:75483, ChEBI:CHEBI:15378, ChEBI:CHEBI:60050; Evidence=; Reaction=25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) = 25- hydroxyvitamin D3 sulfate(in) + n H(+)(in); Xref=Rhea:RHEA:75491, ChEBI:CHEBI:15378, ChEBI:CHEBI:194336; Evidence=; Reaction=cholate(out) + n H(+)(out) = cholate(in) + n H(+)(in); Xref=Rhea:RHEA:75499, ChEBI:CHEBI:15378, ChEBI:CHEBI:29747; Evidence=; Reaction=glycocholate(out) + n H(+)(out) = glycocholate(in) + n H(+)(in); Xref=Rhea:RHEA:75503, ChEBI:CHEBI:15378, ChEBI:CHEBI:29746; Evidence=; Reaction=n H(+)(out) + taurocholate(out) = n H(+)(in) + taurocholate(in); Xref=Rhea:RHEA:75507, ChEBI:CHEBI:15378, ChEBI:CHEBI:36257; Evidence=; Reaction=dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) = dehydroepiandrosterone 3-sulfate(in) + n H(+)(in); Xref=Rhea:RHEA:75487, ChEBI:CHEBI:15378, ChEBI:CHEBI:57905; Evidence=; Reaction=n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in); Xref=Rhea:RHEA:76371, ChEBI:CHEBI:15378, ChEBI:CHEBI:155830; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76372; Evidence=; Reaction=2',3'-cGAMP(out) + n H(+)(out) = 2',3'-cGAMP(in) + n H(+)(in); Xref=Rhea:RHEA:76411, ChEBI:CHEBI:15378, ChEBI:CHEBI:143093; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76412; Evidence=; Lysosome membrane ; Multi-pass membrane protein Expressed in liver, kidney, small intestine and colon. In liver, expression gradually increases up to 8 weeks of age. In liver, expression is induced by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); the induction is mediated by AHR. Knockout mice have liver copper levels increased by around 30%, with no differences in iron contents. Mutants are resistant to TCDD and high-fat diet-induced hepatic triglyceride accumlation and after 3 of high-fat diet feeding, body weight changes, liver mass and epididymal fat mass are reduced compared to wild-type mice. Belongs to the major facilitator superfamily. SLC46A family. molecular_function integral component of plasma membrane biological_process membrane integral component of membrane transmembrane transport uc009aom.1 uc009aom.2 uc009aom.3 
ENSMUST00000118531.8 Egfem1 ENSMUST00000118531.8 EGF-like and EMI domain containing 1, transcript variant 2 (from RefSeq NM_001167748.3) B7ZCE8 EGFEM_MOUSE ENSMUST00000118531.1 ENSMUST00000118531.2 ENSMUST00000118531.3 ENSMUST00000118531.4 ENSMUST00000118531.5 ENSMUST00000118531.6 ENSMUST00000118531.7 NM_001167748 Q149G1 Q8C088 uc008ouk.1 uc008ouk.2 uc008ouk.3 uc008ouk.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C088-1; Sequence=Displayed; Name=2; IsoId=Q8C088-2; Sequence=VSP_034213; calcium ion binding cellular_component biological_process uc008ouk.1 uc008ouk.2 uc008ouk.3 uc008ouk.4 
ENSMUST00000118535.9 Rab4a ENSMUST00000118535.9 RAB4A, member RAS oncogene family, transcript variant 2 (from RefSeq NR_188946.1) ENSMUST00000118535.1 ENSMUST00000118535.2 ENSMUST00000118535.3 ENSMUST00000118535.4 ENSMUST00000118535.5 ENSMUST00000118535.6 ENSMUST00000118535.7 ENSMUST00000118535.8 NR_188946 P56371 Q3TSQ6 RAB4A_MOUSE Rab4 uc009nwo.1 uc009nwo.2 uc009nwo.3 uc009nwo.4 Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:14697203). Involved in protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (PubMed:14697203). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Interacts with SGSM1, SGSM2 and SGSM3 (PubMed:17509819). Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1 (PubMed:11172003). Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin. Interacts (in GTP-bound form) with GRIPAP1 (via N-terminus). Interacts with RABEP1 and RBSN (By similarity). Does not interact with HPS4 (By similarity). Does not interact with HPS4 (PubMed:20048159). Interacts with RABEP2; this interaction may mediate VEGFR2 cell surface expression (By similarity). Membrane ; Peripheral membrane protein Cytoplasm Early endosome membrane ; Peripheral membrane protein Recycling endosome membrane ; Peripheral membrane protein Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. Expressed in the central nervous system, including cortex, cerebellum, midbrain and spinal cord, and in the kidney, lung, liver and spleen. Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity. Phosphorylated by CDK1 kinase during mitosis. Belongs to the small GTPase superfamily. Rab family. It is uncertain whether Met-1 or Met-6 is the initiator. Sequence=BAA24034.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding ATPase activator activity GTPase activity GTP binding cytoplasm endosome cytosol plasma membrane intracellular protein transport small GTPase mediated signal transduction protein transport membrane GDP binding antigen processing and presentation syntaxin binding regulation of endocytosis cytoplasmic vesicle membrane early endosome membrane vesicle Rab protein signal transduction insulin-responsive compartment positive regulation of ATPase activity ionotropic glutamate receptor binding intracellular membrane-bounded organelle perinuclear region of cytoplasm ATPase binding recycling endosome recycling endosome membrane extracellular exosome postsynaptic recycling endosome anchored component of synaptic vesicle membrane uc009nwo.1 uc009nwo.2 uc009nwo.3 uc009nwo.4 
ENSMUST00000118539.2 Cth ENSMUST00000118539.2 cystathionine gamma lyase (from RefSeq NM_145953.2) CGL_MOUSE ENSMUST00000118539.1 NM_145953 Q6H324 Q8VCN5 uc008rvj.1 uc008rvj.2 uc008rvj.3 Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate. Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione. Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L- homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce hydrogen sulfide (H2S). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, and two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia. Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively (By similarity). Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (PubMed:19903941, PubMed:22244329). By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (PubMed:18948540) (By similarity). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (PubMed:33826201). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity). Reaction=H2O + L,L-cystathionine = 2-oxobutanoate + L-cysteine + NH4(+); Xref=Rhea:RHEA:14005, ChEBI:CHEBI:15377, ChEBI:CHEBI:16763, ChEBI:CHEBI:28938, ChEBI:CHEBI:35235, ChEBI:CHEBI:58161; EC=4.4.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14006; Evidence=; Reaction=H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) + pyruvate; Xref=Rhea:RHEA:24931, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:29919, ChEBI:CHEBI:35235; EC=4.4.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24932; Evidence=; Reaction=H2O + L-homocysteine = 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+); Xref=Rhea:RHEA:14501, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16763, ChEBI:CHEBI:28938, ChEBI:CHEBI:29919, ChEBI:CHEBI:58199; EC=4.4.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14502; Evidence=; Reaction=L-homoserine = 2-oxobutanoate + NH4(+); Xref=Rhea:RHEA:24923, ChEBI:CHEBI:16763, ChEBI:CHEBI:28938, ChEBI:CHEBI:57476; EC=4.4.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24924; Evidence=; Reaction=H2O + L-selenocystathionine = 2-oxobutanoate + L- selenocysteine + NH4(+); Xref=Rhea:RHEA:31151, ChEBI:CHEBI:15377, ChEBI:CHEBI:16763, ChEBI:CHEBI:28938, ChEBI:CHEBI:57843, ChEBI:CHEBI:62226; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31152; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Activated by calmodulin in the presence of calcium ions. Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2. Homotetramer (By similarity). Interacts with CALM in a calcium-dependent manner (PubMed:18948540). Cytoplasm Detected in liver and kidney, and at lower levels in small intestine (at protein level) (PubMed:15038791). Highly expressed in liver, kidney and lung, detected at lower levels in stomach, small intestine and adipose tissue, and hardly found in heart, bone, and thymus (PubMed:15038791, PubMed:20305127). First detected at low levels in embryonic liver after 12.5 days of embryonic development. Highly expressed in liver and kidney after 18.5 days of embryonic development. Expressed at high levels in liver and kidney after birth and in adults. Age-dependent expression in mouse skeletal muscles; protein expression in skeletal muscles increased 5 days after birth, and remained stable until 10 weeks, then slightly decreased at 26 weeks and was significantly lower at 51 weeks (PubMed:33826201). Tumor necrosis factor alpha (TNF-alpha) promotes the binding of SP1 to the CSE promoter, inducing its transcription. No visible phenotype at birth. Mice exhibit strongly decreased levels of hydrogen sulfide (H2S) in heart and aorta. Mice also show absence of protein sulfhydration on target proteins. Hydrogen sulfide serum levels are also lower than normal. No effect on brain hydrogen sulfide levels. Age-dependent hypertension beginning at about seven weeks of age (PubMed:18948540, PubMed:19903941). Deteriorated the loss of skeletal muscle mass in aging mice (PubMed:33826201). Belongs to the trans-sulfuration enzymes family. catalytic activity cystathionine beta-lyase activity cystathionine gamma-lyase activity protein binding calmodulin binding cytoplasm cytosol glutathione metabolic process negative regulation of cell proliferation cellular amino acid biosynthetic process lyase activity carbon-sulfur lyase activity protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine cysteine biosynthetic process via cystathionine cysteine biosynthetic process transsulfuration pyridoxal phosphate binding negative regulation of cell growth identical protein binding negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling protein sulfhydration L-cystine L-cysteine-lyase (deaminating) homocysteine metabolic process positive regulation of NF-kappaB transcription factor activity protein homotetramerization hydrogen sulfide biosynthetic process L-cysteine desulfhydrase activity positive regulation of aortic smooth muscle cell differentiation cellular response to leukemia inhibitory factor negative regulation of apoptotic signaling pathway uc008rvj.1 uc008rvj.2 uc008rvj.3 
ENSMUST00000118549.8 Celf6 ENSMUST00000118549.8 CUGBP, Elav-like family member 6, transcript variant 4 (from RefSeq NM_001413521.1) Celf6 D3YU11 D3YU11_MOUSE ENSMUST00000118549.1 ENSMUST00000118549.2 ENSMUST00000118549.3 ENSMUST00000118549.4 ENSMUST00000118549.5 ENSMUST00000118549.6 ENSMUST00000118549.7 NM_001413521 uc292hup.1 uc292hup.2 Nucleus Belongs to the CELF/BRUNOL family. nucleic acid binding RNA binding uc292hup.1 uc292hup.2 
ENSMUST00000118557.8 Pex11b ENSMUST00000118557.8 peroxisomal biogenesis factor 11 beta, transcript variant 4 (from RefSeq NR_027844.1) ENSMUST00000118557.1 ENSMUST00000118557.2 ENSMUST00000118557.3 ENSMUST00000118557.4 ENSMUST00000118557.5 ENSMUST00000118557.6 ENSMUST00000118557.7 NR_027844 PX11B_MOUSE Q8C4G1 Q9D090 Q9Z210 uc008qnn.1 uc008qnn.2 uc008qnn.3 uc008qnn.4 Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface. Homodimer. Heterodimer with PEX11G. Interacts with PEX19. Interacts with FIS1. Peroxisome membrane ; Single-pass membrane protein Mice have a marked decrease in peroxisome abundance. They share several phenotypes with Zellweger syndrome mouse models, including neuronal migration defects, hypotonia, a developmental delay, and neonatal lethality but no detectable defect in peroxisomal protein import and only mild defects in peroxisomal metabolic function. Belongs to the peroxin-11 family. mitochondrion peroxisome peroxisomal membrane integral component of peroxisomal membrane peroxisome organization signal transduction membrane integral component of membrane peroxisome fission macromolecular complex protein homodimerization activity regulation of peroxisome size protein homooligomerization uc008qnn.1 uc008qnn.2 uc008qnn.3 uc008qnn.4 
ENSMUST00000118574.8 Naip6 ENSMUST00000118574.8 Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (PubMed:21874021). The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri. May contribute to prevent motor-neuron apoptosis induced by a variety of signals (By similarity). (from UniProt Q9JIB6) AF135494 BIR1F_MOUSE Birc1f ENSMUST00000118574.1 ENSMUST00000118574.2 ENSMUST00000118574.3 ENSMUST00000118574.4 ENSMUST00000118574.5 ENSMUST00000118574.6 ENSMUST00000118574.7 Naip-rs4 O09121 O09122 P81704 Q8CH68 Q9JIB6 uc288pni.1 uc288pni.2 Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (PubMed:21874021). The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri. May contribute to prevent motor-neuron apoptosis induced by a variety of signals (By similarity). Component of the NLRC4 inflammasome, at least composed of NLRC4, caspase-1 (CASP1) and some NAIP protein. (Microbial infection) Interacts with S.typhimurium (Salmonella) flagellin. Q9JIB6; Q48824: flaA; Xeno; NbExp=2; IntAct=EBI-15944303, EBI-15944232; nucleotide binding immune system process protein binding ATP binding cytoplasm apoptotic process inflammatory response detection of bacterium defense response to bacterium neuron projection neuronal cell body cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process perikaryon innate immune response metal ion binding pyroptosis cellular response to estrogen stimulus IPAF inflammasome complex uc288pni.1 uc288pni.2 
ENSMUST00000118575.2 Gm16066 ENSMUST00000118575.2 Gm16066 (from geneSymbol) AK145039 ENSMUST00000118575.1 uc289pyf.1 uc289pyf.2 uc289pyf.1 uc289pyf.2 
ENSMUST00000118592.8 Ccdc186 ENSMUST00000118592.8 coiled-coil domain containing 186 (from RefSeq NM_170757.2) CC186_MOUSE ENSMUST00000118592.1 ENSMUST00000118592.2 ENSMUST00000118592.3 ENSMUST00000118592.4 ENSMUST00000118592.5 ENSMUST00000118592.6 ENSMUST00000118592.7 NM_170757 Otg1 Q6P3D6 Q8C9S4 Q8CJC0 uc008hzg.1 uc008hzg.2 uc008hzg.3 Expressed in postnatal germ cells. It is uncertain whether Met-1 or Met-19 is the initiator. Sequence=AAH64039.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; molecular_function cellular_component response to bacterium uc008hzg.1 uc008hzg.2 uc008hzg.3 
ENSMUST00000118616.3 H2ab2 ENSMUST00000118616.3 H2A.B variant histone 2 (from RefSeq NM_001281530.1) ENSMUST00000118616.1 ENSMUST00000118616.2 H2ab2 NM_001281530 S4R1M3 S4R1M3_MOUSE uc033jsg.1 uc033jsg.2 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. CCDS Note: There are no publicly available full-length transcripts representing this CCDS in mouse. The CDS structure is based on the alignment of paralogous histone H2afb transcripts (BC061062.1). ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 25731851 ##RefSeq-Attributes-END## The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2A family. nucleosome nuclear nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization transcriptionally active chromatin protein heterodimerization activity uc033jsg.1 uc033jsg.2 
ENSMUST00000118649.8 Apoc3 ENSMUST00000118649.8 apolipoprotein C-III, transcript variant 2 (from RefSeq NM_001289756.1) A0A0R4J1N3 A0A0R4J1N3_MOUSE Apoc3 ENSMUST00000118649.1 ENSMUST00000118649.2 ENSMUST00000118649.3 ENSMUST00000118649.4 ENSMUST00000118649.5 ENSMUST00000118649.6 ENSMUST00000118649.7 NM_001289756 uc033jkg.1 uc033jkg.2 uc033jkg.3 This gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Secreted Belongs to the apolipoprotein C3 family. extracellular region lipid transport lipid binding lipoprotein metabolic process uc033jkg.1 uc033jkg.2 uc033jkg.3 
ENSMUST00000118663.9 Akr1c19 ENSMUST00000118663.9 Belongs to the aldo/keto reductase family. (from UniProt G3X9Y6) Akr1c19 BC087964 ENSMUST00000118663.1 ENSMUST00000118663.2 ENSMUST00000118663.3 ENSMUST00000118663.4 ENSMUST00000118663.5 ENSMUST00000118663.6 ENSMUST00000118663.7 ENSMUST00000118663.8 G3X9Y6 G3X9Y6_MOUSE uc011yvz.1 uc011yvz.2 uc011yvz.3 Belongs to the aldo/keto reductase family. alditol:NADP+ 1-oxidoreductase activity cytosol prostaglandin metabolic process alcohol dehydrogenase (NADP+) activity steroid metabolic process steroid dehydrogenase activity oxidoreductase activity bile acid binding progesterone metabolic process daunorubicin metabolic process doxorubicin metabolic process androsterone dehydrogenase activity ketosteroid monooxygenase activity oxidation-reduction process uc011yvz.1 uc011yvz.2 uc011yvz.3 
ENSMUST00000118666.8 P2ry10 ENSMUST00000118666.8 purinergic receptor P2Y, G-protein coupled 10, transcript variant 2 (from RefSeq NM_001357810.1) A2ASC0 ENSMUST00000118666.1 ENSMUST00000118666.2 ENSMUST00000118666.3 ENSMUST00000118666.4 ENSMUST00000118666.5 ENSMUST00000118666.6 ENSMUST00000118666.7 NM_001357810 P2Y10_MOUSE Q7TMT1 Q8BFU7 uc009uca.1 uc009uca.2 uc009uca.3 Putative receptor for purines coupled to G-proteins. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Sequence=CAM22200.1; Type=Erroneous gene model prediction; Evidence=; G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane positive regulation of Rho protein signal transduction G-protein coupled purinergic nucleotide receptor signaling pathway G-protein coupled purinergic nucleotide receptor activity positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway uc009uca.1 uc009uca.2 uc009uca.3 
ENSMUST00000118682.3 Or51p1 ENSMUST00000118682.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1B0GSZ2) A0A1B0GSZ2 A0A1B0GSZ2_MOUSE ENSMUST00000118682.1 ENSMUST00000118682.2 Olfr588 Or51p1 uc291tpg.1 uc291tpg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tpg.1 uc291tpg.2 
ENSMUST00000118717.10 Akr1c14 ENSMUST00000118717.10 Belongs to the aldo/keto reductase family. (from UniProt Q91WT7) AK136528 Akr1c14 ENSMUST00000118717.1 ENSMUST00000118717.2 ENSMUST00000118717.3 ENSMUST00000118717.4 ENSMUST00000118717.5 ENSMUST00000118717.6 ENSMUST00000118717.7 ENSMUST00000118717.8 ENSMUST00000118717.9 Q91WT7 Q91WT7_MOUSE uc007pji.1 uc007pji.2 uc007pji.3 Belongs to the aldo/keto reductase family. alditol:NADP+ 1-oxidoreductase activity cytosol prostaglandin metabolic process alcohol dehydrogenase (NADP+) activity steroid metabolic process steroid dehydrogenase activity oxidoreductase activity hippocampus development bile acid binding progesterone metabolic process daunorubicin metabolic process doxorubicin metabolic process androsterone dehydrogenase activity ketosteroid monooxygenase activity oxidation-reduction process uc007pji.1 uc007pji.2 uc007pji.3 
ENSMUST00000118724.8 1700034E13Rik ENSMUST00000118724.8 RIKEN cDNA 1700034E13 gene (from RefSeq NM_030097.1) 1700034E13Rik ENSMUST00000118724.1 ENSMUST00000118724.2 ENSMUST00000118724.3 ENSMUST00000118724.4 ENSMUST00000118724.5 ENSMUST00000118724.6 ENSMUST00000118724.7 NM_030097 Q9D2T6 Q9D2T6_MOUSE uc008exj.1 uc008exj.2 uc008exj.3 molecular_function cellular_component biological_process uc008exj.1 uc008exj.2 uc008exj.3 
ENSMUST00000118733.8 Ank1 ENSMUST00000118733.8 ankyrin 1, erythroid, transcript variant 7 (from RefSeq NM_001277289.2) Ank1 D3YTV8 D3YTV8_MOUSE ENSMUST00000118733.1 ENSMUST00000118733.2 ENSMUST00000118733.3 ENSMUST00000118733.4 ENSMUST00000118733.5 ENSMUST00000118733.6 ENSMUST00000118733.7 NM_001277289 uc009lej.1 uc009lej.2 uc009lej.3 uc009lej.4 Cytoplasm, cytoskeleton Membrane signal transduction uc009lej.1 uc009lej.2 uc009lej.3 uc009lej.4 
ENSMUST00000118736.4 Or10ag55-ps1 ENSMUST00000118736.4 Or10ag55-ps1 (from geneSymbol) ENSMUST00000118736.1 ENSMUST00000118736.2 ENSMUST00000118736.3 uc289xur.1 uc289xur.2 uc289xur.1 uc289xur.2 
ENSMUST00000118755.8 Prss36 ENSMUST00000118755.8 serine protease 36 (from RefSeq NM_001319147.1) E9QJT0 E9QJT0_MOUSE ENSMUST00000118755.1 ENSMUST00000118755.2 ENSMUST00000118755.3 ENSMUST00000118755.4 ENSMUST00000118755.5 ENSMUST00000118755.6 ENSMUST00000118755.7 NM_001319147 Prss36 uc057cba.1 uc057cba.2 Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1. Secreted, extracellular space, extracellular matrix Note=Not attached to membranes. serine-type endopeptidase activity cytoplasm proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc057cba.1 uc057cba.2 
ENSMUST00000118769.2 Zar1l ENSMUST00000118769.2 zygote arrest 1-like (from RefSeq NM_001159693.2) C3VD30 ENSMUST00000118769.1 NM_001159693 ZAR1L_MOUSE Zar1l Zar2 uc012ehm.1 uc012ehm.2 uc012ehm.3 mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:31598710). Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity). Binds to the 3'-UTR of maternal mRNAs, inhibiting their translation (PubMed:31598710). Interacts with YBX2. Cytoplasm, Cytoplasmic ribonucleoprotein granule Expressed in oocytes and zygotes (PubMed:20014101, PubMed:31598710). Predominantly expressed in maturing oocytes before maternal-to-zygotic transition (MZT) (PubMed:31598710). Less abundant than Zar1 (PubMed:31598710). Accumulates during oocyte growth and degradaded after meiotic resumption: present in germinal vesicle (GV) stage oocytes and decreases during meiotic maturation and fertilization, and undetectable in 2-cell embryos. Disordered region at the N-terminus undergoes liquid-liquid phase separation (LLPS) for the formation of membraneless compartments that store maternal mRNAs in oocytes. The 3CxxC-type mediates binding to the 3'-UTR of mRNAs. No visible phenotype: mice are viable and females are fertile (PubMed:31598710). Mice lacking Zar1 and Zar1l oocytes display delayed meiotic resumption and polar body-1 emission and a higher incidence of abnormal meiotic spindle formation and chromosome aneuploidy (PubMed:31598710). The grown oocytes of Zar1 and Zar1l mutant mice contain decreased levels of many maternal mRNAs and display a reduced level of protein synthesis (PubMed:31598710). Belongs to the ZAR1 family. protein binding cytoplasm biological_process uc012ehm.1 uc012ehm.2 uc012ehm.3 
ENSMUST00000118793.3 Gm16181 ENSMUST00000118793.3 Gm16181 (from geneSymbol) AK080258 ENSMUST00000118793.1 ENSMUST00000118793.2 uc008cgw.1 uc008cgw.2 uc008cgw.3 uc008cgw.4 uc008cgw.1 uc008cgw.2 uc008cgw.3 uc008cgw.4 
ENSMUST00000118808.9 Emc10 ENSMUST00000118808.9 ER membrane protein complex subunit 10, transcript variant 1 (from RefSeq NM_197991.3) EMC10_MOUSE ENSMUST00000118808.1 ENSMUST00000118808.2 ENSMUST00000118808.3 ENSMUST00000118808.4 ENSMUST00000118808.5 ENSMUST00000118808.6 ENSMUST00000118808.7 ENSMUST00000118808.8 Hsm1 Inm02 NM_197991 Q3TAS6 Q3TFU1 Q5UCC3 Q5UCC5 Q8VCD8 Q99JJ8 uc012fjp.1 uc012fjp.2 uc012fjp.3 uc012fjp.4 Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N- exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways (PubMed:28931551). Component of the ER membrane protein complex (EMC). [Isoform 2]: Secreted [Isoform 1]: Endoplasmic reticulum membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TAS6-1; Sequence=Displayed; Name=2; Synonyms=Hematopoietic signal peptide-containing secreted protein 1, HSS1; IsoId=Q3TAS6-2; Sequence=VSP_030475; Up-regulated in the left ventricle 3 days after myocardial infarction (MI). Expressed predominantly by monocytes and macrophages from bone marrow, spleen, and peripheral blood 3 days after MI (protein level). Knockout mice show no cardiovascular phenotype at baseline. After myocardial infarction however, capillarization of the infarct border zone is impaired and the animals develop larger infarct scars and more pronounced left ventricular remodeling and systolic dysfunction compared with wild-type mice. Belongs to the EMC10 family. Sequence=BAE40807.1; Type=Erroneous initiation; Evidence=; Sequence=BAE42592.1; Type=Erroneous initiation; Evidence=; angiogenesis positive regulation of endothelial cell proliferation molecular_function extracellular region positive regulation of endothelial cell migration membrane integral component of membrane positive regulation of angiogenesis ER membrane protein complex positive regulation of p38MAPK cascade uc012fjp.1 uc012fjp.2 uc012fjp.3 uc012fjp.4 
ENSMUST00000118809.3 Or1p4-ps1 ENSMUST00000118809.3 Or1p4-ps1 (from geneSymbol) ENSMUST00000118809.1 ENSMUST00000118809.2 uc288abv.1 uc288abv.2 uc288abv.1 uc288abv.2 
ENSMUST00000118820.8 Gpr174 ENSMUST00000118820.8 G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response. Plays a negative role in regulatory T-cell accumulation and homeostasis (PubMed:26077720). Under inflammatory conditions where LysoPS production increases, contributes to the down-regulation of regulatory T-cell activity to favor effector response (PubMed:26077720). Mediates the suppression of IL-2 production in activated T-lymphocytes leading to inhibition of growth, proliferation and differentiation of T-cells (PubMed:29457279). Mechanistically, acts via G(12)/G(13)-containing heterotrimeric G proteins to trigger elevated cyclic AMP levels and protein kinase A/PKA activity, which may in turn act to antagonize proximal TCR signaling (PubMed:29457279). Plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions (PubMed:30850582). Upon testosterone treatment, acts as a receptor for CCL21 and subsequently triggers through G(q)-alpha and G(12)/G(13) proteins a calcium flux leading to chemotactic effects on activated B-cells (PubMed:31875850). Signals via GNA13 and PKA to promote CD86 up-regulation by follicular B-cells (PubMed:35639700). (from UniProt Q3U507) AK156069 ENSMUST00000118820.1 ENSMUST00000118820.2 ENSMUST00000118820.3 ENSMUST00000118820.4 ENSMUST00000118820.5 ENSMUST00000118820.6 ENSMUST00000118820.7 GP174_MOUSE Gm376 Q3U507 uc009ucd.1 uc009ucd.2 uc009ucd.3 uc009ucd.4 G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response. Plays a negative role in regulatory T-cell accumulation and homeostasis (PubMed:26077720). Under inflammatory conditions where LysoPS production increases, contributes to the down-regulation of regulatory T-cell activity to favor effector response (PubMed:26077720). Mediates the suppression of IL-2 production in activated T-lymphocytes leading to inhibition of growth, proliferation and differentiation of T-cells (PubMed:29457279). Mechanistically, acts via G(12)/G(13)-containing heterotrimeric G proteins to trigger elevated cyclic AMP levels and protein kinase A/PKA activity, which may in turn act to antagonize proximal TCR signaling (PubMed:29457279). Plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions (PubMed:30850582). Upon testosterone treatment, acts as a receptor for CCL21 and subsequently triggers through G(q)-alpha and G(12)/G(13) proteins a calcium flux leading to chemotactic effects on activated B-cells (PubMed:31875850). Signals via GNA13 and PKA to promote CD86 up-regulation by follicular B-cells (PubMed:35639700). Interacts with GNA13. Interacts with CCL21. Cell membrane; Multi-pass membrane protein. Expressed in spleen and, at low levels, in brain (PubMed:23178570). Highly expressed in developing and mature regulatory T-cells (PubMed:26077720, PubMed:30850582). GPR174 deficiency appears to favor regulatory T- cells cell accumulation in specific tissues (PubMed:26077720). Knock- out mice are resistant to inflammatory shock induced by lipopolysaccharide (LPS) and cecal ligation and puncture (CLP) (PubMed:30850582). GPR174-deficient B-cells have a defect in CD86 up- regulation (PubMed:35639700). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane positive regulation of Rho protein signal transduction T cell homeostasis bioactive lipid receptor activity positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway uc009ucd.1 uc009ucd.2 uc009ucd.3 uc009ucd.4 
ENSMUST00000118821.8 Pramel3a ENSMUST00000118821.8 PRAME like 3A (from RefSeq NM_031390.2) A2AHA7 ENSMUST00000118821.1 ENSMUST00000118821.2 ENSMUST00000118821.3 ENSMUST00000118821.4 ENSMUST00000118821.5 ENSMUST00000118821.6 ENSMUST00000118821.7 NM_031390 Pramel3 Pramel3a Q99M97 Q99M97_MOUSE uc292qol.1 uc292qol.2 molecular_function cellular_component cytoplasm biological_process uc292qol.1 uc292qol.2 
ENSMUST00000118831.8 Syt3 ENSMUST00000118831.8 Belongs to the synaptotagmin family. (from UniProt G3X9Y1) D45858 ENSMUST00000118831.1 ENSMUST00000118831.2 ENSMUST00000118831.3 ENSMUST00000118831.4 ENSMUST00000118831.5 ENSMUST00000118831.6 ENSMUST00000118831.7 G3X9Y1 G3X9Y1_MOUSE Syt3 uc009gph.1 uc009gph.2 uc009gph.3 uc009gph.4 Belongs to the synaptotagmin family. endosome membrane integral component of membrane calcium ion regulated exocytosis positive regulation of dendrite extension uc009gph.1 uc009gph.2 uc009gph.3 uc009gph.4 
ENSMUST00000118842.2 Dmrtc1b ENSMUST00000118842.2 Belongs to the DMRT family. (from UniProt Q2PMX7) DQ316776 Dmrt8.2 Dmrtc1b ENSMUST00000118842.1 Q2PMX7 Q2PMX7_MOUSE uc009tyv.1 uc009tyv.2 Belongs to the DMRT family. transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated protein homodimerization activity uc009tyv.1 uc009tyv.2 
ENSMUST00000118853.8 Gask1b ENSMUST00000118853.8 Golgi apparatus membrane ; Single-pass type II membrane protein (from UniProt Q3UPI1) AK052367 B3VSA6 ENSMUST00000118853.1 ENSMUST00000118853.2 ENSMUST00000118853.3 ENSMUST00000118853.4 ENSMUST00000118853.5 ENSMUST00000118853.6 ENSMUST00000118853.7 Ened Fam198b GAK1B_MOUSE Gask1b Q3UPI1 Q6PGJ9 Q8C781 Q9ET25 uc290gce.1 uc290gce.2 Golgi apparatus membrane ; Single-pass type II membrane protein Expressed in heart and midgut at 9.5 day post- conception (dpc). Expressed in floor plate, peripheral nervous system, lens epithelium, skin, midline dorsal aorta, lung, kidney and testis from 10 dpc onwards. Belongs to the GASK family. Sequence=BAC34959.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi membrane molecular_function Golgi apparatus biological_process membrane integral component of membrane uc290gce.1 uc290gce.2 
ENSMUST00000118856.8 Brme1 ENSMUST00000118856.8 break repair meiotic recombinase recruitment factor 1, transcript variant 1 (from RefSeq NM_029045.3) A0A0R4J144 BRME1_MOUSE Brme1 E9QNR8 ENSMUST00000118856.1 ENSMUST00000118856.2 ENSMUST00000118856.3 ENSMUST00000118856.4 ENSMUST00000118856.5 ENSMUST00000118856.6 ENSMUST00000118856.7 Meiok21 NM_029045 Q6DIA7 Q9D5J2 uc009mmc.1 uc009mmc.2 uc009mmc.3 uc009mmc.4 Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair (PubMed:32463460, PubMed:32460033). Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination (PubMed:32460033, PubMed:32463460). Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (PubMed:32463460, PubMed:32460033). Interacts with HSF2BP (via N-terminus) and BRCA2; the interaction with HSF2BP is direct and allows the formation of a ternary complex (PubMed:32345962, PubMed:32460033, PubMed:32463460, PubMed:32845237). The complex BRME1:HSF2BP:BRCA2 interacts with SPATA22, MEIOB and RAD51 (PubMed:32345962). Chromosome te=During meiosis, recruited to chromosomes and localizes on recombination sites in a double-strand break-dependent manner. First appears on the chromosome axis at leptotene. Along with the progression of meiotic recombination, released from the axis to form bridge-like structures linking homolog axes before they are synapsed. Finally, located between synapsed homolog axes and on the synaptonemal complex (SC). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6DIA7-1; Sequence=Displayed; Name=2; IsoId=Q6DIA7-2; Sequence=VSP_027045; Expressed in testis. Expressed in fetal ovaries but not in adult ovaries. Male mutants are infertile (PubMed:32463460, PubMed:32460033, PubMed:32345962). They have smaller-than-normal testes with reduced diameters of seminiferous tubules and sperm density (PubMed:32460033, PubMed:32345962). Female mutants exhibit normal fertility with no apparent defect in adult ovaries (PubMed:32460033, PubMed:32345962). They show a strong reduction of the follicle pool. cellular_component biological_process uc009mmc.1 uc009mmc.2 uc009mmc.3 uc009mmc.4 
ENSMUST00000118867.8 Isg20 ENSMUST00000118867.8 interferon-stimulated protein, transcript variant 3 (from RefSeq NM_001291221.1) ENSMUST00000118867.1 ENSMUST00000118867.2 ENSMUST00000118867.3 ENSMUST00000118867.4 ENSMUST00000118867.5 ENSMUST00000118867.6 ENSMUST00000118867.7 ISG20_MOUSE NM_001291221 Q9CPZ5 Q9JL16 uc057ahz.1 uc057ahz.2 uc057ahz.3 Interferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA. Inhibition of several viruses does not involve the degradation of viral RNAs, but rather the inhibition of translation of viral proteins (PubMed:30232164). Exerts a translational control over a large panel of non-self RNA substrates while sparing endogenous transcripts. This activity correlates with the protein's ability to localize in cytoplasmic processing bodies (PubMed:31600344). May also act as master regulator of over hundred interferon stimulated genes leading to viral genome translation inhibition (PubMed:30232164). May play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (By similarity). Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.13.1; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.; pH dependence: Optimum pH is 7.0.; Associates with PML and SP100 in the PML NB complex. Associates with survival motor neuron protein (SMN)-containing macromolecular nuclear complexes and U1 and U2 snRNAs and U3 snoRNA (By similarity). Nucleus Nucleus, nucleolus Cytoplasm Nucleus, Cajal body Cytoplasm, P-body Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JL16-1; Sequence=Displayed; Name=2; IsoId=Q9JL16-2; Sequence=VSP_012431, VSP_012432; Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased expression was seen at the transcriptional level (By similarity). ISG20-deletion mice exhibit higher mortality following vesicular stomatitis virus challenge (PubMed:31600344). They also show a slightly earlier onset of symptoms when infected with venezuelan equine encephalitis virus. However, weight loss and the median survival times for infected mice are essentially equivalent between the deletion mutant and the WT. Belongs to the exonuclease superfamily. 3'-5'-exoribonuclease activity DNA catabolic process, exonucleolytic immune system process nucleic acid binding RNA binding nuclease activity exonuclease activity nucleus nucleolus cytoplasm rRNA processing RNA catabolic process single-stranded DNA 3'-5' exodeoxyribonuclease activity exoribonuclease II activity response to virus Cajal body PML body hydrolase activity U1 snRNA binding U2 snRNA binding U3 snoRNA binding negative regulation of viral genome replication innate immune response metal ion binding defense response to virus RNA phosphodiester bond hydrolysis, exonucleolytic uc057ahz.1 uc057ahz.2 uc057ahz.3 
ENSMUST00000118886.9 Snrk ENSMUST00000118886.9 SNF related kinase, transcript variant 1 (from RefSeq NM_133741.2) ENSMUST00000118886.1 ENSMUST00000118886.2 ENSMUST00000118886.3 ENSMUST00000118886.4 ENSMUST00000118886.5 ENSMUST00000118886.6 ENSMUST00000118886.7 ENSMUST00000118886.8 NM_133741 Q8VDU5 Q91WX6 SNRK_MOUSE Snrk uc009seo.1 uc009seo.2 uc009seo.3 uc009seo.4 May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Activated by phosphorylation on Thr-173. Nucleus Ubiquitously expressed in all tissues examined. Expressed from day 8 dpc along the epithelium of the differentiating neural tube. Expression persists along the dorsal axis until 12.5 dpc, but becomes progressively restricted to the more caudal part of the neural tube with much stronger intensity in the caudal neuropore. Also observed in the endoderm of the primitive gut between 8.5 and 11.5 dpc, at 10.5 dpc, in the endocardium and pericardium of the developing heart, and in both the endothelium and blood cells clustered at the ventral part of the dorsal aorta. Later in development (12.5 dpc), expressed in the endocardium and the interventricular septum of the heart. Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity intracellular signal transduction metal ion binding uc009seo.1 uc009seo.2 uc009seo.3 uc009seo.4 
ENSMUST00000118896.2 Sgcz ENSMUST00000118896.2 sarcoglycan zeta (from RefSeq NM_145841.2) ENSMUST00000118896.1 NM_145841 Q3UVZ2 Q8BX51 Q8K1E7 SGCZ_MOUSE uc009lme.1 uc009lme.2 uc009lme.3 Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability. Cell membrane, sarcolemma ; Single- pass type II membrane protein Cytoplasm, cytoskeleton Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=Q8BX51-1; Sequence=Displayed; Name=2; IsoId=Q8BX51-2; Sequence=VSP_018885; Expressed in the heart, skeletal muscle and arterial vascular smooth muscle. Belongs to the sarcoglycan beta/delta/gamma/zeta family. protein binding cytoplasm cytoskeleton plasma membrane sarcoglycan complex membrane integral component of membrane sarcolemma cardiac muscle tissue development heart contraction membrane organization uc009lme.1 uc009lme.2 uc009lme.3 
ENSMUST00000118902.8 Nfyc ENSMUST00000118902.8 nuclear transcription factor-Y gamma, transcript variant 23 (from RefSeq NR_185292.1) ENSMUST00000118902.1 ENSMUST00000118902.2 ENSMUST00000118902.3 ENSMUST00000118902.4 ENSMUST00000118902.5 ENSMUST00000118902.6 ENSMUST00000118902.7 NFYC_MOUSE NR_185292 O35088 P70353 Q6GU21 uc008unp.1 uc008unp.2 uc008unp.3 uc008unp.4 Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding (By similarity). Nucleus. Belongs to the NFYC/HAP5 subunit family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated transcription factor binding CCAAT-binding factor complex protein-DNA complex transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity RNA polymerase II transcription factor complex uc008unp.1 uc008unp.2 uc008unp.3 uc008unp.4 
ENSMUST00000118919.9 Fam131a ENSMUST00000118919.9 Belongs to the FAM131 family. (from UniProt D3Z4E4) AK049983 D3Z4E4 D3Z4E4_MOUSE ENSMUST00000118919.1 ENSMUST00000118919.2 ENSMUST00000118919.3 ENSMUST00000118919.4 ENSMUST00000118919.5 ENSMUST00000118919.6 ENSMUST00000118919.7 ENSMUST00000118919.8 Fam131a uc289dnd.1 uc289dnd.2 Belongs to the FAM131 family. uc289dnd.1 uc289dnd.2 
ENSMUST00000118927.8 Zdhhc13 ENSMUST00000118927.8 zinc finger, DHHC domain containing 13 (from RefSeq NM_028031.3) ENSMUST00000118927.1 ENSMUST00000118927.2 ENSMUST00000118927.3 ENSMUST00000118927.4 ENSMUST00000118927.5 ENSMUST00000118927.6 ENSMUST00000118927.7 Hip14l NM_028031 Q3UK32 Q3UKV1 Q9CWU2 ZDH13_MOUSE Zdhhc13 uc009haw.1 uc009haw.2 uc009haw.3 Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:18794299, PubMed:19299482). Palmitoyltransferase for HTT and GAD2 (PubMed:19299482, PubMed:20548961). May play a role in Mg(2+) transport (PubMed:18794299). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with HTT (PubMed:26198635). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (PubMed:26198635). Interacts (via ANK repeats) with SNAP25 (PubMed:25253725, PubMed:26198635). May interact (via ANK repeats) with SPRED2 (PubMed:28882895). Golgi apparatus membrane ulti-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi vesicles. Expressed in most adult tissues, but at low levels in the liver, skin, and lung. Expressed most highly in the liver, lung, and brain at posnatal day 2 (P2). In contrast, expressed most highly in skin at P8 in the epithelium surrounding the hair follicles. Up-regulated by low extracellular Mg(2+). The DHHC domain is required for palmitoyltransferase activity. Knockdown of the expression in mice through ENU- induced stop codon in the gene or targeted knockout of the gene result is similar phenotypes (PubMed:20548961). Mutant mice are normal at birth, but by postnatal day 7 appear smaller (PubMed:20548961). They display generalized hypotrichosis and hair loss with altered skin that is loose with wrinkling and folding (PubMed:20548961). Kyphosis and osteoporosisis are also observed (PubMed:20548961). Finally, a generalized amyloid deposition results in early death (PubMed:20548961). Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. Golgi membrane protein binding endoplasmic reticulum Golgi apparatus magnesium ion transmembrane transporter activity membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups protein-cysteine S-palmitoyltransferase activity cytoplasmic vesicle membrane Golgi-associated vesicle membrane cytoplasmic vesicle magnesium ion transmembrane transport uc009haw.1 uc009haw.2 uc009haw.3 
ENSMUST00000118942.8 Disc1 ENSMUST00000118942.8 Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:17825401, PubMed:19502360, PubMed:31444471). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (PubMed:17825401, PubMed:19502360). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (PubMed:19778506). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (PubMed:19778506). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA- binding (PubMed:31444471). Plays a role, together with PCNT, in the microtubule network formation (By similarity). (from UniProt Q811T9) AF513723 DISC1_MOUSE Disc1 ENSMUST00000118942.1 ENSMUST00000118942.2 ENSMUST00000118942.3 ENSMUST00000118942.4 ENSMUST00000118942.5 ENSMUST00000118942.6 ENSMUST00000118942.7 Q7TQ21 Q811T9 Q8CF87 Q8CF88 Q8CHP1 Q8CHP2 uc292ebt.1 uc292ebt.2 Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:17825401, PubMed:19502360, PubMed:31444471). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (PubMed:17825401, PubMed:19502360). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (PubMed:19778506). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (PubMed:19778506). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA- binding (PubMed:31444471). Plays a role, together with PCNT, in the microtubule network formation (By similarity). Interacts with NDEL1 (PubMed:14962739). Interacts with CCDC88A (via C-terminus); the interaction is direct (PubMed:19778506). Interacts with GSK3B (PubMed:19303846). Interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1 (By similarity). Interaction with microtubules may be mediated in part by TRAF3IP1. Interacts (via C- terminal) with PCNT (By similarity). Interacts with CHCHD6 (By similarity). Interacts with CCDC141 (PubMed:20956536). Interacts with FBXW7, the substrate-recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex; the interaction targets DISC1 for proteasomal degradation (By similarity). Interacts with ZNF365 (By similarity). Interacts with ATF4; inhibiting ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA- binding (PubMed:31444471). Interacts with PDE4B (By similarity). Q811T9; Q811T9: Disc1; NbExp=2; IntAct=EBI-2298259, EBI-2298259; Q811T9; Q91VR7: Map1lc3a; NbExp=2; IntAct=EBI-2298259, EBI-2933755; Q811T9; P49841: GSK3B; Xeno; NbExp=4; IntAct=EBI-2298259, EBI-373586; Q811T9-1; O75962-4: TRIO; Xeno; NbExp=2; IntAct=EBI-15881527, EBI-15915736; Cytoplasm Cytoplasm, cytoskeleton Mitochondrion Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Postsynaptic density Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (PubMed:14962739). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q811T9-1; Sequence=Displayed; Name=2; IsoId=Q811T9-2; Sequence=VSP_019318; Name=3; IsoId=Q811T9-3; Sequence=VSP_019321; Name=4; Synonyms=ES; IsoId=Q811T9-4; Sequence=VSP_019319, VSP_019320; Expressed in granule cell precursors within the dentate migratory stream during the first week of postnatal life and in differentiated granule cells of the hippocampus (at protein level). Detected in heart, brain, kidney, and testis (PubMed:12504857). Expressed in dentate gyrus, hippocampus and in the olfactory bulb. Expressed in neuronal progenitors residing in the ventricular and subventriculare zones and in postmitotic neurons in the cortical plate of the cerebral cortex at 15 dpc. Expressed in granule cell precursors within the dentate migratory stream of the hippocampus at 19 dpc (at protein level). Ubiquitinated. Ubiquitination with 'Lys-48'-linked polyubiquitin chains leads to its proteasomal degradation. Loss of function of DISC1 in the dentate gyrus of adult mice results in reduced neural progenitor cell proliferation and the appearance of schizophrenic and depressive-like behaviors. microtubule cytoskeleton organization neuron migration positive regulation of cell-matrix adhesion positive regulation of neuroblast proliferation protein binding nucleus cytoplasm mitochondrion endoplasmic reticulum centrosome microtubule organizing center cytosol cytoskeleton kinesin complex microtubule plasma membrane multicellular organism development nervous system development synaptic vesicle regulation of neuron projection development positive regulation of neuron projection development postsynaptic density membrane Wnt signaling pathway kinesin binding cerebral cortex radially oriented cell migration cell proliferation in forebrain pyramidal neuron migration cell junction positive regulation of Wnt signaling pathway dynein complex axon TOR signaling negative regulation of protein binding cellular protein localization ciliary basal body cell body macromolecular complex binding intermediate filament cytoskeleton synapse postsynaptic membrane positive regulation of axon extension perinuclear region of cytoplasm mitochondrial calcium ion homeostasis response to electrical stimulus regulation of synaptic transmission, glutamatergic canonical Wnt signaling pathway binding, bridging cilium assembly regulation of dendritic spine development protein localization to centrosome regulation of synapse maturation central region of growth cone ciliary base non-motile cilium assembly positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc292ebt.1 uc292ebt.2 
ENSMUST00000118957.2 Or4x12-ps1 ENSMUST00000118957.2 Or4x12-ps1 (from geneSymbol) ENSMUST00000118957.1 uc289yet.1 uc289yet.2 uc289yet.1 uc289yet.2 
ENSMUST00000118960.2 Car15 ENSMUST00000118960.2 carbonic anhydrase 15 (from RefSeq NM_030558.2) CAH15_MOUSE Ca15 ENSMUST00000118960.1 NM_030558 Q99N23 uc007ymg.1 uc007ymg.2 uc007ymg.3 Reversible hydration of carbon dioxide. Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Repressed by coumarins. Secreted Belongs to the alpha-carbonic anhydrase family. carbonate dehydratase activity extracellular region zinc ion binding membrane lyase activity anchored component of plasma membrane metal ion binding uc007ymg.1 uc007ymg.2 uc007ymg.3 
ENSMUST00000118976.10 Ccdc9 ENSMUST00000118976.10 coiled-coil domain containing 9, transcript variant 5 (from RefSeq NM_001382413.3) Ccdc9 D3YW42 D3YW42_MOUSE ENSMUST00000118976.1 ENSMUST00000118976.2 ENSMUST00000118976.3 ENSMUST00000118976.4 ENSMUST00000118976.5 ENSMUST00000118976.6 ENSMUST00000118976.7 ENSMUST00000118976.8 ENSMUST00000118976.9 NM_001382413 uc009fhm.1 uc009fhm.2 uc009fhm.3 uc009fhm.4 uc009fhm.5 uc009fhm.1 uc009fhm.2 uc009fhm.3 uc009fhm.4 uc009fhm.5 
ENSMUST00000118986.8 Tbx22 ENSMUST00000118986.8 T-box 22, transcript variant 1 (from RefSeq NM_145224.3) ENSMUST00000118986.1 ENSMUST00000118986.2 ENSMUST00000118986.3 ENSMUST00000118986.4 ENSMUST00000118986.5 ENSMUST00000118986.6 ENSMUST00000118986.7 NM_145224 Q8K402 TBX22_MOUSE uc012hnt.1 uc012hnt.2 uc012hnt.3 uc012hnt.4 Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. Nucleus Expressed in a temporally and spatially highly restricted pattern during mouse palate and tongue development. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cell fate specification DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc012hnt.1 uc012hnt.2 uc012hnt.3 uc012hnt.4 
ENSMUST00000118993.8 Tpst1 ENSMUST00000118993.8 protein-tyrosine sulfotransferase 1, transcript variant 2 (from RefSeq NM_013837.2) ENSMUST00000118993.1 ENSMUST00000118993.2 ENSMUST00000118993.3 ENSMUST00000118993.4 ENSMUST00000118993.5 ENSMUST00000118993.6 ENSMUST00000118993.7 NM_013837 Q4FK50 Q4FK50_MOUSE Tpst1 uc008zuc.1 uc008zuc.2 uc008zuc.3 uc008zuc.4 uc008zuc.5 Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. Reaction=3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]; Xref=Rhea:RHEA:16801, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:11688, ChEBI:CHEBI:15378, ChEBI:CHEBI:46858, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:65286; EC=2.8.2.20; Evidence= Golgi apparatus membrane ; Single-pass type II membrane protein Belongs to the protein sulfotransferase family. peptidyl-tyrosine sulfation protein-tyrosine sulfotransferase activity transferase activity integral component of Golgi membrane protein homodimerization activity uc008zuc.1 uc008zuc.2 uc008zuc.3 uc008zuc.4 uc008zuc.5 
ENSMUST00000119003.2 Zfp617 ENSMUST00000119003.2 zinc finger protein 617 (from RefSeq NM_133358.3) ENSMUST00000119003.1 NM_133358 Q91WM0 Q91WM0_MOUSE Zfp617 uc009mez.1 uc009mez.2 uc009mez.3 uc009mez.4 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc009mez.1 uc009mez.2 uc009mez.3 uc009mez.4 
ENSMUST00000119014.8 Pigg ENSMUST00000119014.8 phosphatidylinositol glycan anchor biosynthesis, class G, transcript variant 4 (from RefSeq NR_163827.1) D3Z3Y1 D3Z3Y1_MOUSE ENSMUST00000119014.1 ENSMUST00000119014.2 ENSMUST00000119014.3 ENSMUST00000119014.4 ENSMUST00000119014.5 ENSMUST00000119014.6 ENSMUST00000119014.7 NR_163827 Pigg uc008ynv.1 uc008ynv.2 uc008ynv.3 uc008ynv.4 Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily. catalytic activity endoplasmic reticulum GPI anchor biosynthetic process membrane integral component of membrane integral component of endoplasmic reticulum membrane CP2 mannose-ethanolamine phosphotransferase activity mannose-ethanolamine phosphotransferase activity uc008ynv.1 uc008ynv.2 uc008ynv.3 uc008ynv.4 
ENSMUST00000119026.8 Tmem132c ENSMUST00000119026.8 transmembrane protein 132C (from RefSeq NM_175432.3) E9QP73 E9QP73_MOUSE ENSMUST00000119026.1 ENSMUST00000119026.2 ENSMUST00000119026.3 ENSMUST00000119026.4 ENSMUST00000119026.5 ENSMUST00000119026.6 ENSMUST00000119026.7 NM_175432 Tmem132c uc008zry.1 uc008zry.2 uc008zry.3 uc008zry.4 Membrane ; Single- pass type I membrane protein Belongs to the TMEM132 family. membrane integral component of membrane uc008zry.1 uc008zry.2 uc008zry.3 uc008zry.4 
ENSMUST00000119031.8 Adal ENSMUST00000119031.8 Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A). (from UniProt Q80SY6) A2ARU3 A2ARU4 ADAL_MOUSE AK049697 ENSMUST00000119031.1 ENSMUST00000119031.2 ENSMUST00000119031.3 ENSMUST00000119031.4 ENSMUST00000119031.5 ENSMUST00000119031.6 ENSMUST00000119031.7 Q80SY6 Q8BLN3 Q8BX67 Q9D4Q6 uc289zvr.1 uc289zvr.2 Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A). Reaction=H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine; Xref=Rhea:RHEA:16001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58053, ChEBI:CHEBI:59338, ChEBI:CHEBI:144842; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16002; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Monomer. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80SY6-1; Sequence=Displayed; Name=2; IsoId=Q80SY6-2; Sequence=VSP_024822; Name=3; IsoId=Q80SY6-3; Sequence=VSP_024823, VSP_024824; Name=4; IsoId=Q80SY6-4; Sequence=VSP_024825; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Sequence=CAM18206.1; Type=Erroneous gene model prediction; Evidence=; adenosine deaminase activity cellular_component adenosine catabolic process nucleotide metabolic process hydrolase activity deaminase activity inosine biosynthetic process metal ion binding uc289zvr.1 uc289zvr.2 
ENSMUST00000119078.8 Mbd6 ENSMUST00000119078.8 methyl-CpG binding domain protein 6, transcript variant 3 (from RefSeq NM_001379570.1) E9PWH8 ENSMUST00000119078.1 ENSMUST00000119078.2 ENSMUST00000119078.3 ENSMUST00000119078.4 ENSMUST00000119078.5 ENSMUST00000119078.6 ENSMUST00000119078.7 MBD6_MOUSE NM_001379570 Q3TY92 uc007hix.1 uc007hix.2 uc007hix.3 Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro) (By similarity). Nucleus Chromosome Note=Associated with pericentric heterochromatin in about 25% of the cells. Ubiquitous. Expressed at highest levels in adult testis and brain. Detected in embryo from 7 to 17 dpc. The MBD domain is necessary for chromocentric localization. fibrillar center chromatin binding nucleus nucleoplasm chromosome biological_process chromocenter DNA binding uc007hix.1 uc007hix.2 uc007hix.3 
ENSMUST00000119080.8 Gjb1 ENSMUST00000119080.8 gap junction protein, beta 1, transcript variant 2 (from RefSeq NM_001302496.1) CXB1_MOUSE Cxn-32 ENSMUST00000119080.1 ENSMUST00000119080.2 ENSMUST00000119080.3 ENSMUST00000119080.4 ENSMUST00000119080.5 ENSMUST00000119080.6 ENSMUST00000119080.7 NM_001302496 P28230 uc057ash.1 uc057ash.2 uc057ash.3 This gene is a member of the gap junction protein (connexin) family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of ions and small molecules between cells. Mutations in a similar gene in human cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Oct 2014]. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Interacts with CNST. Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Mice lacking both Gja12 and Gjb1 display a severe demyelination phenotype associated with oligodendrocyte death. These mice develop action tremors, tonic seizures, sporadic convulsions and loss of consciousness preceding death in the sixth week after birth. Belongs to the connexin family. Beta-type (group I) subfamily. gap junction channel activity cytoplasm endoplasmic reticulum plasma membrane gap junction connexin complex cell communication purine ribonucleotide transport membrane integral component of membrane lateral plasma membrane cell junction protein homodimerization activity protein oligomerization transmembrane transport uc057ash.1 uc057ash.2 uc057ash.3 
ENSMUST00000119096.2 Klra4 ENSMUST00000119096.2 killer cell lectin-like receptor, subfamily A, member 4, transcript variant 1 (from RefSeq NM_010649.4) ENSMUST00000119096.1 KLRA4_MOUSE Ly-49d Ly49-d Ly49d NM_010649 O78026 Q60651 Q9EPA5 uc009ehj.1 uc009ehj.2 uc009ehj.3 uc009ehj.4 Receptor on natural killer (NK) cells for class I MHC. Homodimer; disulfide-linked. Interacts with the adapter protein TYROBP/DAP12; the interaction leads to natural killer cell activation (PubMed:9647200). Cell membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=D1; IsoId=Q60651-1; Sequence=Displayed; Name=D2; IsoId=Q60651-2; Sequence=VSP_003068; protein binding plasma membrane cell adhesion external side of plasma membrane cell surface membrane integral component of membrane carbohydrate binding uc009ehj.1 uc009ehj.2 uc009ehj.3 uc009ehj.4 
ENSMUST00000119103.2 Bco2 ENSMUST00000119103.2 beta-carotene oxygenase 2, transcript variant 1 (from RefSeq NM_133217.3) BCDO2_MOUSE Bcdo2 Bco2 ENSMUST00000119103.1 NM_133217 Q99NF1 uc009pjq.1 uc009pjq.2 uc009pjq.3 Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids (PubMed:11278918, PubMed:21106934). Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta- cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond (PubMed:11278918, PubMed:21106934). Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules (PubMed:21106934). Reaction=all-trans-beta-carotene + O2 = all-trans-10'-apo-beta- carotenal + beta-ionone; Xref=Rhea:RHEA:26389, ChEBI:CHEBI:15379, ChEBI:CHEBI:17579, ChEBI:CHEBI:32325, ChEBI:CHEBI:53153; EC=1.13.11.71; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26390; Evidence=; Reaction=5-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9-trien- 2-one + 5-cis-10'-apo-lycopenal; Xref=Rhea:RHEA:68444, ChEBI:CHEBI:15379, ChEBI:CHEBI:67207, ChEBI:CHEBI:177905, ChEBI:CHEBI:177906; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68445; Evidence=; Reaction=13-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9- trien-2-one + 13-cis-10'-apo-lycopenal; Xref=Rhea:RHEA:68448, ChEBI:CHEBI:15379, ChEBI:CHEBI:67207, ChEBI:CHEBI:177907, ChEBI:CHEBI:177908; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68449; Evidence=; Reaction=lutein + O2 = (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)- hydroxy-alpha-ionone; Xref=Rhea:RHEA:68428, ChEBI:CHEBI:15379, ChEBI:CHEBI:28838, ChEBI:CHEBI:177902, ChEBI:CHEBI:177904; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68429; Evidence=; Reaction=lutein + O2 = (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy- 10'-apo-alpha-carotenal; Xref=Rhea:RHEA:68432, ChEBI:CHEBI:15379, ChEBI:CHEBI:28838, ChEBI:CHEBI:53173, ChEBI:CHEBI:177903; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68433; Evidence=; Reaction=all-trans-zeaxanthin + 2 O2 = 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial; Xref=Rhea:RHEA:26393, ChEBI:CHEBI:15379, ChEBI:CHEBI:27547, ChEBI:CHEBI:53171, ChEBI:CHEBI:53173; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26394; Evidence=; Reaction=all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-10'-apo-beta- carotenal + (3R)-hydroxy-beta-ionone; Xref=Rhea:RHEA:68104, ChEBI:CHEBI:15379, ChEBI:CHEBI:27547, ChEBI:CHEBI:53173, ChEBI:CHEBI:177902; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68105; Evidence=; Reaction=beta-cryptoxanthin + O2 = (3R)-hydroxy-beta-ionone + all- trans-10'-apo-beta-carotenal; Xref=Rhea:RHEA:68440, ChEBI:CHEBI:10362, ChEBI:CHEBI:15379, ChEBI:CHEBI:53153, ChEBI:CHEBI:53173; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68441; Evidence=; Reaction=all-trans-10'-apo-beta-carotenal + O2 = 4,9-dimethyldodeca- 2,4,6,8,10-pentaenedial + beta-ionone; Xref=Rhea:RHEA:68452, ChEBI:CHEBI:15379, ChEBI:CHEBI:32325, ChEBI:CHEBI:53153, ChEBI:CHEBI:53171; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68453; Evidence=; Reaction=(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 = (3R)-hydroxy- beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial; Xref=Rhea:RHEA:68424, ChEBI:CHEBI:15379, ChEBI:CHEBI:53171, ChEBI:CHEBI:53173, ChEBI:CHEBI:177902; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68425; Evidence=; Reaction=(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 = (3R,6R)- hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial; Xref=Rhea:RHEA:68436, ChEBI:CHEBI:15379, ChEBI:CHEBI:53171, ChEBI:CHEBI:177903, ChEBI:CHEBI:177904; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68437; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Mitochondrion Expressed in small intestine, liver, kidney, testis and less abundantly in spleen, brain, lung, and heart. Up-regulated by carotenoids. Homozygous knockout mice lacking Bcdo2 develop normally, and both females and males are fertile when raised on standard diet (PubMed:21106934). On a diet supplemented with xanthophylls, knockout mice accumulate derivatives of these xanthophylls in all tested tissues and develop liver steatosis with large lipid droplets in hepatocytes and a significantly increased triacylglyceride content (PubMed:21106934). Accumulated carotenoids impair mitochondrial respiration, induce ROS production and cellular signaling pathways related to oxidative stress (PubMed:21106934). Belongs to the carotenoid oxygenase family. beta-carotene 15,15'-monooxygenase activity retinal isomerase activity mitochondrion carotenoid dioxygenase activity carotenoid metabolic process carotene metabolic process carotene catabolic process xanthophyll metabolic process oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen retinoic acid metabolic process retinal metabolic process metal ion binding dioxygenase activity regulation of mitochondrial membrane potential oxidation-reduction process regulation of reactive oxygen species metabolic process uc009pjq.1 uc009pjq.2 uc009pjq.3 
ENSMUST00000119109.8 Etv3 ENSMUST00000119109.8 Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. (from UniProt Q8R4Z4) AK147552 ENSMUST00000119109.1 ENSMUST00000119109.2 ENSMUST00000119109.3 ENSMUST00000119109.4 ENSMUST00000119109.5 ENSMUST00000119109.6 ENSMUST00000119109.7 ETV3_MOUSE G5E907 Mets Pe1 Q8R4Z4 Q9QZW1 uc008psh.1 uc008psh.2 uc008psh.3 uc008psh.4 Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. Nucleus Belongs to the ETS family. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter negative regulation of cell proliferation transcriptional repressor complex DEAD/H-box RNA helicase binding cell differentiation sequence-specific DNA binding RNA polymerase II transcription repressor complex cellular response to granulocyte macrophage colony-stimulating factor stimulus uc008psh.1 uc008psh.2 uc008psh.3 uc008psh.4 
ENSMUST00000119118.8 Entrep2 ENSMUST00000119118.8 endosomal transmembrane epsin interactor 2 (from RefSeq NM_183087.4) ENSMUST00000119118.1 ENSMUST00000119118.2 ENSMUST00000119118.3 ENSMUST00000119118.4 ENSMUST00000119118.5 ENSMUST00000119118.6 ENSMUST00000119118.7 EREP2_MOUSE Entrep2 Fam189a1 Kiaa0574 NM_183087 Q6A044 Q8BHP9 uc009hgl.1 uc009hgl.2 uc009hgl.3 uc009hgl.4 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6A044-1; Sequence=Displayed; Name=2; IsoId=Q6A044-2; Sequence=VSP_032011; Belongs to the ENTREP family. Sequence=BAD32252.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc009hgl.1 uc009hgl.2 uc009hgl.3 uc009hgl.4 
ENSMUST00000119129.10 Cdon ENSMUST00000119129.10 cell adhesion molecule-related/down-regulated by oncogenes, transcript variant 4 (from RefSeq NM_021339.3) CDON_MOUSE Cdo E9QKV9 ENSMUST00000119129.1 ENSMUST00000119129.2 ENSMUST00000119129.3 ENSMUST00000119129.4 ENSMUST00000119129.5 ENSMUST00000119129.6 ENSMUST00000119129.7 ENSMUST00000119129.8 ENSMUST00000119129.9 NM_021339 O88971 Q32MD9 uc009ote.1 uc009ote.2 uc009ote.3 uc009ote.4 Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Required for response to NTN3 and activation of NFATC3. Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3. Interacts with DHH, IHH and SHH (By similarity). Q32MD9; P00520: Abl1; NbExp=2; IntAct=EBI-7017034, EBI-914519; Q32MD9; Q01721: Gas1; NbExp=3; IntAct=EBI-7017034, EBI-15729104; Cell membrane ; Single-pass membrane protein Highly expressed in somites and the dorsal lips of the neural tube during embryogenesis. Detected at very low levels in adult tissues. Transiently up-regulated during myoblast differentiation. N-glycosylated. cell fate specification positive regulation of protein phosphorylation lens development in camera-type eye protein binding plasma membrane integral component of plasma membrane cell adhesion smoothened signaling pathway myoblast fusion anterior/posterior pattern specification cell surface embryonic body morphogenesis skeletal muscle satellite cell differentiation membrane integral component of membrane regulation of striated muscle tissue development cerebral cortex development regulation of protein binding positive regulation of MAPK cascade positive regulation of myoblast differentiation regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter embryonic morphogenesis positive regulation of skeletal muscle tissue development positive regulation of small GTPase mediated signal transduction striated muscle cell differentiation embryonic retina morphogenesis in camera-type eye cell-cell adhesion positive regulation of neural precursor cell proliferation uc009ote.1 uc009ote.2 uc009ote.3 uc009ote.4 
ENSMUST00000119133.3 1700064H15Rik ENSMUST00000119133.3 1700064H15Rik (from geneSymbol) AK006881 ENSMUST00000119133.1 ENSMUST00000119133.2 uc290eag.1 uc290eag.2 uc290eag.3 uc290eag.1 uc290eag.2 uc290eag.3 
ENSMUST00000119166.8 Zcchc2 ENSMUST00000119166.8 zinc finger, CCHC domain containing 2, transcript variant B (from RefSeq NM_001122675.1) ENSMUST00000119166.1 ENSMUST00000119166.2 ENSMUST00000119166.3 ENSMUST00000119166.4 ENSMUST00000119166.5 ENSMUST00000119166.6 ENSMUST00000119166.7 Kiaa1744 NM_001122675 Q69ZB8 Q7TNF1 Q8CB08 ZCHC2_MOUSE uc007cgq.1 uc007cgq.2 uc007cgq.3 uc007cgq.4 uc007cgq.5 uc007cgq.6 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69ZB8-1; Sequence=Displayed; Name=2; IsoId=Q69ZB8-2; Sequence=VSP_013721; molecular_function nucleic acid binding cytoplasm biological_process zinc ion binding phosphatidylinositol binding metal ion binding uc007cgq.1 uc007cgq.2 uc007cgq.3 uc007cgq.4 uc007cgq.5 uc007cgq.6 
ENSMUST00000119180.4 Sycn ENSMUST00000119180.4 syncollin (from RefSeq NM_026716.3) ENSMUST00000119180.1 ENSMUST00000119180.2 ENSMUST00000119180.3 NM_026716 Q8VCK7 SYCN_MOUSE uc009fzf.1 uc009fzf.2 uc009fzf.3 uc009fzf.4 Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues. Monomer and homooligomer; most probably hexameric. Interacts with GP2 (By similarity). Zymogen granule membrane ; Peripheral membrane protein ; Lumenal side Zymogen granule lumen Note=Associated in a cholesterol- dependent manner with lipid rafts of zymogen granule membranes. Contains intrachain disulfide bonds. Mice display reduced rates of protein synthesis and intracellular transport of secretory proteins. According to PubMed:15040787 mice lacking Sycn display atrophy of the pancreas associated with an elevated amylase content. exocytosis membrane transport vesicle membrane secretory granule membrane cytoplasmic vesicle uc009fzf.1 uc009fzf.2 uc009fzf.3 uc009fzf.4 
ENSMUST00000119223.2 E2f8 ENSMUST00000119223.2 E2F transcription factor 8, transcript variant 1 (from RefSeq NM_001360812.1) E2F8_MOUSE ENSMUST00000119223.1 NM_001360812 Q3U4W2 Q497V7 Q58FA4 Q5PRE4 Q8BQJ5 Q8C3Y5 uc009hba.1 uc009hba.2 uc009hba.3 Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Interacts with HIF1A (By similarity). Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA-binding. Q58FA4; Q58FA4: E2f8; NbExp=3; IntAct=EBI-1390691, EBI-1390691; Nucleus Highly expressed in liver, skin, thymus and testis. Expressed in trophoblast giant cells throughout placenta development (at protein level). Induced at the onset of hepatocyte polyploidization. In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity). No visible phenotype; mice develop normally and live to old age. E2f7 and E2f8 double knockout embryos die by 11.5 dpc of massive apoptosis and dilation of blood vessels and show increased expression of E2f1 and p53/Tp53, as well as many stress-related genes. Belongs to the E2F/DP family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding placenta development sprouting angiogenesis DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity nucleus transcription factor complex nucleolus cytosol regulation of transcription, DNA-templated cell cycle transcription factor binding cell proliferation negative regulation of cytokinesis positive regulation of DNA endoreduplication cell cycle comprising mitosis without cytokinesis identical protein binding protein homodimerization activity sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter regulation of cell cycle trophoblast giant cell differentiation chorionic trophoblast cell differentiation hepatocyte differentiation RNA polymerase II transcription factor complex uc009hba.1 uc009hba.2 uc009hba.3 
ENSMUST00000119231.8 Gm6121 ENSMUST00000119231.8 Belongs to the XLR/SYCP3 family. (from UniProt L7MUF1) ENSMUST00000119231.1 ENSMUST00000119231.2 ENSMUST00000119231.3 ENSMUST00000119231.4 ENSMUST00000119231.5 ENSMUST00000119231.6 ENSMUST00000119231.7 Gm6121 L7MUF1 L7MUF1_MOUSE uc292nof.1 uc292nof.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc292nof.1 uc292nof.2 
ENSMUST00000119245.8 Trip4 ENSMUST00000119245.8 thyroid hormone receptor interactor 4, transcript variant 1 (from RefSeq NM_019797.4) E9QK64 ENSMUST00000119245.1 ENSMUST00000119245.2 ENSMUST00000119245.3 ENSMUST00000119245.4 ENSMUST00000119245.5 ENSMUST00000119245.6 ENSMUST00000119245.7 NM_019797 Q8CAD5 Q9QXN3 TRIP4_MOUSE Trip4 uc012gvn.1 uc012gvn.2 uc012gvn.3 Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (By similarity). Also involved in androgen receptor transactivation (PubMed:12077347). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction (By similarity). May play a role in late myogenic differentiation (PubMed:27008887). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (By similarity). Interacts with the thyroid hormone receptor/TR (via the ligand-binding domain); this interaction requires the presence of thyroid hormone (By similarity). Interacts with the androgen receptor/AR; in an androgen, testosterone and dihydrotestosterone- dependent manner (By similarity). Interacts with ESR1 (estrogen ligand- bound); competes with UFSP2 (By similarity). Interacts with UFSP2; competes with ligand-bound ESR1 (By similarity). Interacts with DDRGK1 and UFL1; the interaction with DDRGK1 is direct (By similarity). Interacts with NCOA1 (By similarity). Interacts with EP300 (By similarity). Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347). Identified in the RQT (ribosome quality control trigger) complex, that contains ASCC2, ASCC3 and TRIP4 (By similarity). Interacts with NEK6 (By similarity). Interacts with CSRP1 (By similarity). Interacts with ZCCHC4 (By similarity). Nucleus Cytoplasm, cytosol Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Cytoplasmic under conditions of serum deprivation. Colocalizes with NEK6 in the centrosome. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QXN3-1; Sequence=Displayed; Name=2; IsoId=Q9QXN3-2; Sequence=VSP_011109, VSP_011110; Ubiquitously expressed (PubMed:12390891). Expressed in the spinal cord, brain, paraspinal ganglia, thyroid, and submandibular glands (PubMed:26924529). Expressed at low level in all the muscles (at protein level) but with higher expression in axial than in limb muscles (PubMed:27008887). Expressed in 17.5-day-old embryos. The C4-type zinc finger mediates a competitive interaction with UFSP2 and ligand-bound nuclear receptors. It also mediates interaction with the transcriptional coactivators and the basal transcription machinery. Phosphorylated by NEK6. Polyufmylated by the UFM1-conjugating system composed of the enzymes UBA5, UFC1 and UFL1. Deufmylated by the protease UFSP2. Ufmylation of TRIP4 is promoted by ligand-bound nuclear receptors that compete with UFSP2 for interaction with TRIP4. Nuclear receptors- induced ufmylation promotes the recruitment of additional transcriptional coactivators like EP300 and NCOA1 and therefore the assembly of a coactivator complex facilitating nuclear receptor- mediated transcription. protease binding transcription coactivator activity nucleus nucleoplasm cytoplasm centrosome microtubule organizing center cytosol cytoskeleton regulation of transcription, DNA-templated zinc ion binding nuclear body ligand-dependent nuclear receptor binding protein kinase binding estrogen receptor binding intracellular estrogen receptor signaling pathway neuromuscular junction macromolecular complex histone acetyltransferase binding ubiquitin-like protein ligase binding regulation of myoblast differentiation positive regulation of transcription, DNA-templated metal ion binding activating signal cointegrator 1 complex toxin transport uc012gvn.1 uc012gvn.2 uc012gvn.3 
ENSMUST00000119267.2 Or51k7 ENSMUST00000119267.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1B0GRN7) A0A1B0GRN7 A0A1B0GRN7_MOUSE ENSMUST00000119267.1 Or51k7 uc291tsi.1 uc291tsi.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tsi.1 uc291tsi.2 
ENSMUST00000119274.3 Stk38 ENSMUST00000119274.3 serine/threonine kinase 38, transcript variant 2 (from RefSeq NM_001357173.1) ENSMUST00000119274.1 ENSMUST00000119274.2 NM_001357173 Ndr1 Q91VJ4 STK38_MOUSE Stk38 uc008bsb.1 uc008bsb.2 uc008bsb.3 Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium- dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N- terminal of STK38. Homodimeric S100B binds two molecules of STK38. Interacts with MOB1 and MOB2 (By similarity). Interacts with MAP3K1 and MAP3K2 (via the kinase catalytic domain) (By similarity). Forms a tripartite complex with MOBKL1B and STK3/MST2 (By similarity). Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (PubMed:21730291). Q91VJ4; Q8VDP3: Mical1; NbExp=9; IntAct=EBI-2527046, EBI-4394891; Q91VJ4; Q13043: STK4; Xeno; NbExp=2; IntAct=EBI-2527046, EBI-367376; Nucleus Cytoplasm Expressed at high levels in spleen, lung, thymus, brain and fat tissue. ISGylated. Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm cytosol cellular protein modification process protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation mitogen-activated protein kinase kinase kinase binding intracellular signal transduction negative regulation of MAP kinase activity metal ion binding uc008bsb.1 uc008bsb.2 uc008bsb.3 
ENSMUST00000119284.8 Prkd3 ENSMUST00000119284.8 protein kinase D3, transcript variant 1 (from RefSeq NM_001171004.1) ENSMUST00000119284.1 ENSMUST00000119284.2 ENSMUST00000119284.3 ENSMUST00000119284.4 ENSMUST00000119284.5 ENSMUST00000119284.6 ENSMUST00000119284.7 NM_001171004 Prkcn Prkd3 Q5FWX6 Q5FWX6_MOUSE uc008dps.1 uc008dps.2 uc008dps.3 uc008dps.4 Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Activated by DAG and phorbol esters. Cytoplasm Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity ATP binding nucleoplasm cytoplasm cytosol protein phosphorylation kinase activity phosphorylation transferase activity intracellular signal transduction metal ion binding uc008dps.1 uc008dps.2 uc008dps.3 uc008dps.4 
ENSMUST00000119285.2 Gm4297 ENSMUST00000119285.2 predicted gene 4297 (from RefSeq NM_001100446.2) D3YWB7 D3YWB7_MOUSE ENSMUST00000119285.1 Gm4297 NM_001100446 uc009svb.1 uc009svb.2 uc009svb.3 uc009svb.4 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc009svb.1 uc009svb.2 uc009svb.3 uc009svb.4 
ENSMUST00000119336.8 Ankrd24 ENSMUST00000119336.8 ankyrin repeat domain 24, transcript variant 2 (from RefSeq NM_027480.3) ANR24_MOUSE E9QJV7 ENSMUST00000119336.1 ENSMUST00000119336.2 ENSMUST00000119336.3 ENSMUST00000119336.4 ENSMUST00000119336.5 ENSMUST00000119336.6 ENSMUST00000119336.7 NM_027480 Q80VM7 uc011xjk.1 uc011xjk.2 uc011xjk.3 Componement of the stereocilia rootlet in hair cells of inner ear. Bridges the apical plasma membrane with the lower rootlet and maintains normal distribution of TRIOBP, thereby reinforcing stereocilia insertion points and organizing rootlets for hearing with long-term resilience. Homodimer (PubMed:35175278). Interacts (via C-terminal domain) with TRIOBP (via C-terminal domain) isoform 4; recruits TRIOBP isoform 4 to stereocilia rootlets (PubMed:35175278). Cell membrane Cell projection, stereocilium Note=Localizes to hair cell stereocilia rootlets. Concentrated to the stereocilia insertion point, forming a ring at the junction between the lower and upper rootlets. Expressed in vestibular hair bundles. Prominently associated with the stereocilia rootlet in outer hair cells (OHCs), inner hair cells (IHCs), and vestibular (utricle) hair cells (VHCs) on postnatal day 7.5. On postnatal day 1.5, is initially present in outer hair cells (OHCs) and inner hair cells (IHCs) as well as at the rootlets. At postnatal day 19.5 is concentrated at stereocilia insertion points. Deficient mice exhibit progressive hearing loss. Loss of Ankrd24 induces morphological changes in hair bundles, early postnatal hair bundles are warped. Stereocilia of deficient mice show diminished recovery of auditory function after noise damage and increased susceptibility to overstimulation of the hair bund. cellular_component biological_process uc011xjk.1 uc011xjk.2 uc011xjk.3 
ENSMUST00000119362.8 Gm10230 ENSMUST00000119362.8 predicted gene 10230, transcript variant 2 (from RefSeq NM_001359718.1) ENSMUST00000119362.1 ENSMUST00000119362.2 ENSMUST00000119362.3 ENSMUST00000119362.4 ENSMUST00000119362.5 ENSMUST00000119362.6 ENSMUST00000119362.7 Gm10058 Gm10096 Gm10147 Gm10230 Gm10486 Gm10487 Gm14632 Gm14819 Gm4836 NM_001359718 Q62478 Q62478_MOUSE XMR uc009svm.1 uc009svm.2 uc009svm.3 uc009svm.4 uc009svm.5 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function nucleus spermatogenesis spermatid development meiotic cell cycle uc009svm.1 uc009svm.2 uc009svm.3 uc009svm.4 uc009svm.5 
ENSMUST00000119365.8 Itga10 ENSMUST00000119365.8 integrin, alpha 10 (from RefSeq NM_001302471.1) E9PXZ3 E9PXZ3_MOUSE ENSMUST00000119365.1 ENSMUST00000119365.2 ENSMUST00000119365.3 ENSMUST00000119365.4 ENSMUST00000119365.5 ENSMUST00000119365.6 ENSMUST00000119365.7 Itga10 NM_001302471 uc012ctz.1 uc012ctz.2 uc012ctz.3 Membrane ingle-pass type I membrane protein Belongs to the integrin alpha chain family. cell adhesion cell-matrix adhesion integrin-mediated signaling pathway integrin complex membrane integral component of membrane integrin alpha10-beta1 complex collagen binding involved in cell-matrix adhesion uc012ctz.1 uc012ctz.2 uc012ctz.3 
ENSMUST00000119374.8 Nkain3 ENSMUST00000119374.8 Na+/K+ transporting ATPase interacting 3, transcript variant 1 (from RefSeq NM_001290410.1) A2ANL4 A6MHP8 A6MHQ0 ENSMUST00000119374.1 ENSMUST00000119374.2 ENSMUST00000119374.3 ENSMUST00000119374.4 ENSMUST00000119374.5 ENSMUST00000119374.6 ENSMUST00000119374.7 Fam77d NKAI3_MOUSE NM_001290410 Q3URJ8 Q6DI91 Q8BPL2 Q8C7P6 uc008scl.1 uc008scl.2 uc008scl.3 Interacts with ATP1B1. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Transcript variant 1; IsoId=Q3URJ8-1; Sequence=Displayed; Name=2; Synonyms=Transcript variant 2; IsoId=Q3URJ8-2; Sequence=VSP_021858; Name=3; Synonyms=Transcript variant 3; IsoId=Q3URJ8-3; Sequence=VSP_029300; Detected in the brain only and specifically in neurons. Expressed in multiple regions such as cerebral cortex, thalamus, hippocampus, olfactory bulb and brainstem as well as in cerebellum with low expression in granular cell layer. Belongs to the NKAIN family. regulation of sodium ion transport plasma membrane membrane integral component of membrane uc008scl.1 uc008scl.2 uc008scl.3 
ENSMUST00000119407.8 Tmem30c ENSMUST00000119407.8 transmembrane protein 30C (from RefSeq NM_027651.1) A9C447 CC50C_MOUSE Cdc50c ENSMUST00000119407.1 ENSMUST00000119407.2 ENSMUST00000119407.3 ENSMUST00000119407.4 ENSMUST00000119407.5 ENSMUST00000119407.6 ENSMUST00000119407.7 NM_027651 Q9D4D7 uc007zne.1 uc007zne.2 uc007zne.3 uc007zne.4 Membrane ; Multi-pass membrane protein Specifically expressed in testis. Belongs to the CDC50/LEM3 family. endoplasmic reticulum Golgi apparatus plasma membrane membrane integral component of membrane phospholipid translocation uc007zne.1 uc007zne.2 uc007zne.3 uc007zne.4 
ENSMUST00000119423.8 Hcrtr1 ENSMUST00000119423.8 Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. (from UniProt P58307) AY336083 ENSMUST00000119423.1 ENSMUST00000119423.2 ENSMUST00000119423.3 ENSMUST00000119423.4 ENSMUST00000119423.5 ENSMUST00000119423.6 ENSMUST00000119423.7 Hcrtr1 OX1R_MOUSE P58307 Q0VDP5 Q3USS9 Q6VNS3 Q80T45 uc290qgg.1 uc290qgg.2 Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. Cell membrane ; Multi-pass membrane protein Widely expressed. The N-terminal region is required for orexin signaling. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity protein binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway feeding behavior membrane integral component of membrane orexin receptor activity peptide hormone binding cellular response to hormone stimulus regulation of cytosolic calcium ion concentration positive regulation of ERK1 and ERK2 cascade uc290qgg.1 uc290qgg.2 
ENSMUST00000119429.8 Myl1 ENSMUST00000119429.8 myosin, light polypeptide 1, transcript variant 5 (from RefSeq NM_001420334.1) ENSMUST00000119429.1 ENSMUST00000119429.2 ENSMUST00000119429.3 ENSMUST00000119429.4 ENSMUST00000119429.5 ENSMUST00000119429.6 ENSMUST00000119429.7 Myl1 NM_001420334 Q545G5 Q545G5_MOUSE uc007bis.1 uc007bis.2 uc007bis.3 uc007bis.4 uc007bis.5 Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. Myosin is a hexamer of 2 heavy chains and 4 light chains. Does not bind calcium. calcium ion binding uc007bis.1 uc007bis.2 uc007bis.3 uc007bis.4 uc007bis.5 
ENSMUST00000119430.3 Samd8 ENSMUST00000119430.3 sterile alpha motif domain containing 8, transcript variant 2 (from RefSeq NM_001359954.1) ENSMUST00000119430.1 ENSMUST00000119430.2 NM_001359954 Q3UH82 Q3UH82_MOUSE Samd8 uc007slr.1 uc007slr.2 uc007slr.3 Membrane ; Multi- pass membrane protein Belongs to the sphingomyelin synthase family. membrane integral component of membrane uc007slr.1 uc007slr.2 uc007slr.3 
ENSMUST00000119453.9 Ankrd60 ENSMUST00000119453.9 Ankrd60 (from geneSymbol) A2AMD2 A2AMD2_MOUSE AK006546 Ankrd60 ENSMUST00000119453.1 ENSMUST00000119453.2 ENSMUST00000119453.3 ENSMUST00000119453.4 ENSMUST00000119453.5 ENSMUST00000119453.6 ENSMUST00000119453.7 ENSMUST00000119453.8 uc008odu.1 uc008odu.2 uc008odu.3 uc008odu.4 molecular_function cellular_component biological_process uc008odu.1 uc008odu.2 uc008odu.3 uc008odu.4 
ENSMUST00000119464.2 Ildr1 ENSMUST00000119464.2 immunoglobulin-like domain containing receptor 1, transcript variant 2 (from RefSeq NM_134109.2) ENSMUST00000119464.1 ILDR1_MOUSE Ildr1 NM_134109 Q6PFB3 Q8CB39 Q8CBR1 Q91VS0 uc007zcs.1 uc007zcs.2 uc007zcs.3 uc007zcs.4 Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs) (PubMed:23239027). Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs (PubMed:25217574). Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine (PubMed:23863714). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (PubMed:28785060). Homooligomer (By similarity). Interacts with MARVELD2 and OCLN; the interaction is required to recruit MARVELD2 to tricellular contacts (PubMed:23239027). Interacts (via C-terminus) with TRA2A, TRA2B and SRSF1 (PubMed:28785060). Interacts with PLSCR1 (By similarity). Cell membrane ingle-pass type I membrane protein Cell junction, tight junction Nucleus Cytoplasm Note=Localizes to tricellular tight junctions (tTJs) between epithelial cells. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha ; IsoId=Q8CBR1-1; Sequence=Displayed; Name=2; IsoId=Q8CBR1-2; Sequence=VSP_019689, VSP_019690; Name=3; IsoId=Q8CBR1-3; Sequence=VSP_019688; Expressed in the vestibule and in hair cells and supporting cells of the cochlea. Expressed in epithelial tissues. Highly expressed in colon but also detected in small intestine, bladder and lung (PubMed:23239027). In colon, expressed in the upper portion of the crypts (at protein level) (PubMed:23239027). Expressed in CCK secretory cells of the proximal small intestine (at protein level) (PubMed:23863714). Expressed in the organ of Corti, stria vascularis, utricle and saccule of the inner ear (PubMed:23239027, PubMed:25217574). Expressed early in development. Mutant mice have early-onset severe deafness associated with a rapid degeneration of cochlear hair cells but have a normal endocochlear potential (PubMed:25217574). Mutants show no increase in plasma CCK levels after orogastric gavage with fatty acids (PubMed:23863714). Belongs to the immunoglobulin superfamily. LISCH7 family. cytosol plasma membrane endocytosis membrane integral component of membrane macromolecular complex identical protein binding protein homooligomerization tricellular tight junction high-density lipoprotein particle receptor activity positive regulation of peptide hormone secretion cellular response to leukemia inhibitory factor uc007zcs.1 uc007zcs.2 uc007zcs.3 uc007zcs.4 
ENSMUST00000119469.2 Pira2 ENSMUST00000119469.2 Pira2 (from geneSymbol) AK137475 D3Z3W9 D3Z3W9_MOUSE ENSMUST00000119469.1 Pira2 uc012ewg.1 uc012ewg.2 uc012ewg.3 molecular_function cellular_component biological_process uc012ewg.1 uc012ewg.2 uc012ewg.3 
ENSMUST00000119481.2 Lrfn5 ENSMUST00000119481.2 leucine rich repeat and fibronectin type III domain containing 5, transcript variant 2 (from RefSeq NM_001310586.1) ENSMUST00000119481.1 Kiaa4208 LRFN5_MOUSE NM_001310586 Q5DTH4 Q8BJH4 Q8BXA0 Q8BZL0 Salm5 uc007nqn.1 uc007nqn.2 uc007nqn.3 uc007nqn.4 uc007nqn.5 Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity). Can form heteromeric complexes with LRFN1, LRFN2, LRFN3 and LFRN4 (By similarity). Able to form homomeric complexes across cell junctions, between adjacent cells (By similarity). Does not interact with DLG1, DLG2 or DLG3 (By similarity). Does not interact with DLG4. Membrane ; Single- pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BXA0-1; Sequence=Displayed; Name=2; IsoId=Q8BXA0-2; Sequence=VSP_009299; Predominantly expressed in the brain, with a weak, but broad expression in the cerebral cortex and diencephalic nuclei. Strongly expressed in both the pyramidal layer and the dentate gyrus of the hippocampus. Also detected in other parts of the central nervous system, including the olfactory bulb, pons, cerebellum, and medulla oblongata, as well as in the peripheral nervous system, such as the ganglia of cranial nerves and the dorsal root ganglion during gestation. Expression starts around 11.5-12.5 dpc. At 11.5 dpc, detected in the outer layer of the telencephalic vesicles. This pattern of expression continues until 17.5 dpc with expression in the cortical plate, but not in the inner layer of the cerebral cortex, including subplate, ventricular zone, and subventricular zone. As also detected in the hippocampus, amygdala and widely in diencephalic nuclei. Lacks a cytoplasmic PDZ-binding motif, which has been implicated in function of related LRFN proteins. Glycosylated. [Isoform 2]: Due to intron retention. Belongs to the LRFN family. Sequence=BAD90535.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding cell surface membrane integral component of membrane negative regulation of macrophage activation negative regulation of inflammatory response glutamatergic synapse GABA-ergic synapse integral component of postsynaptic density membrane synaptic membrane adhesion regulation of presynapse assembly uc007nqn.1 uc007nqn.2 uc007nqn.3 uc007nqn.4 uc007nqn.5 
ENSMUST00000119488.2 Smim10l3 ENSMUST00000119488.2 salivary gland specific protein SAGSIN1 (from RefSeq NM_001395994.1) 2810453I06Rik Acpin1 ENSMUST00000119488.1 Fam220a NM_001395994 Q5U425 Q5U425_MOUSE uc033inq.1 uc033inq.2 uc033inq.3 uc033inq.1 uc033inq.2 uc033inq.3 
ENSMUST00000119492.2 BC025920 ENSMUST00000119492.2 cDNA sequence BC025920 (from RefSeq NR_030677.1) BC025920 ENSMUST00000119492.1 NR_030677 Q3US60 Q3US60_MOUSE uc007giw.1 uc007giw.2 uc007giw.3 uc007giw.4 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc007giw.1 uc007giw.2 uc007giw.3 uc007giw.4 
ENSMUST00000119499.8 Osbpl5 ENSMUST00000119499.8 oxysterol binding protein-like 5, transcript variant 3 (from RefSeq NM_001384163.1) ENSMUST00000119499.1 ENSMUST00000119499.2 ENSMUST00000119499.3 ENSMUST00000119499.4 ENSMUST00000119499.5 ENSMUST00000119499.6 ENSMUST00000119499.7 NM_001384163 OSBL5_MOUSE Obph1 Osbp2 Q8R510 Q99NF5 Q9ER64 uc009kpw.1 uc009kpw.2 uc009kpw.3 uc009kpw.4 Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholesterol. Endoplasmic reticulum membrane ; Single-pass membrane protein Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Localizes to the cortical endoplasmic reticulum at the EPCS. Imprinted gene expressed from the maternal allele in blastocysts. Belongs to the OSBP family. Sequence=CAC16404.2; Type=Erroneous initiation; Evidence=; Sequence=CAC27351.1; Type=Erroneous initiation; Evidence=; phosphatidylserine binding endoplasmic reticulum endoplasmic reticulum membrane cytosol lipid transport lipid binding cholesterol binding phospholipid transport membrane integral component of membrane sterol binding intracellular membrane-bounded organelle phosphatidylinositol-4-phosphate binding uc009kpw.1 uc009kpw.2 uc009kpw.3 uc009kpw.4 
ENSMUST00000119527.8 Iffo1 ENSMUST00000119527.8 intermediate filament family orphan 1, transcript variant 2 (from RefSeq NM_178787.6) ENSMUST00000119527.1 ENSMUST00000119527.2 ENSMUST00000119527.3 ENSMUST00000119527.4 ENSMUST00000119527.5 ENSMUST00000119527.6 ENSMUST00000119527.7 IFFO1_MOUSE Iffo Iffo1 NM_178787 Q3TQI1 Q6PFE6 Q8BXL9 Q8BXS3 Q8C1D6 uc009dtp.1 uc009dtp.2 uc009dtp.3 uc009dtp.4 Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that will relocalize to the DSB sites in a XRCC4- dependent manner and promote the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606). Forms a heterotetramer with XRCC4 (By similarity). The interaction with XRCC4 is direct, involves LIG4-free XRCC4 and leads to relocalization of IFFO1 at the double-strand break (DSB) sites (By similarity). Interacts with LMNA; the interaction forms an interior nucleoskeleton and the recruitment to DNA double-strand breaks (By similarity). Nucleus Nucleus, nucleoplasm Nucleus inner membrane Nucleus matrix Note=Mainly soluble, the remaining is localized in the nuclear matrix. Localized at double-strand break (DSB) sites near the lamina and nuclear matrix structures. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8BXL9-1; Sequence=Displayed; Name=2; IsoId=Q8BXL9-2; Sequence=VSP_030786; Name=3; IsoId=Q8BXL9-3; Sequence=VSP_030785, VSP_030787; Name=4; IsoId=Q8BXL9-4; Sequence=VSP_030785, VSP_030788; Name=5; IsoId=Q8BXL9-5; Sequence=VSP_030787; Name=6; IsoId=Q8BXL9-6; Sequence=VSP_030788; Belongs to the intermediate filament family. molecular_function cellular_component intermediate filament biological_process uc009dtp.1 uc009dtp.2 uc009dtp.3 uc009dtp.4 
ENSMUST00000119567.8 Rufy2 ENSMUST00000119567.8 RUN and FYVE domain-containing 2 (from RefSeq NM_027425.4) ENSMUST00000119567.1 ENSMUST00000119567.2 ENSMUST00000119567.3 ENSMUST00000119567.4 ENSMUST00000119567.5 ENSMUST00000119567.6 ENSMUST00000119567.7 Kiaa1537 NM_027425 Q69ZH1 Q8R4C2 RUFY2_MOUSE uc007fjn.1 uc007fjn.2 uc007fjn.3 Interacts with BMX. Nucleus Expressed only at embryonic stages. Present at 12 dpc in primordial lung, cartilage and otic capsule (at protein level). Sequence=BAD32473.1; Type=Erroneous initiation; Evidence=; nucleus cytoplasm SH3 domain binding metal ion binding uc007fjn.1 uc007fjn.2 uc007fjn.3 
ENSMUST00000119576.8 Mrps17 ENSMUST00000119576.8 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. (from UniProt Q9CQE3) AK134065 ENSMUST00000119576.1 ENSMUST00000119576.2 ENSMUST00000119576.3 ENSMUST00000119576.4 ENSMUST00000119576.5 ENSMUST00000119576.6 ENSMUST00000119576.7 Q9CQE3 RT17_MOUSE Rpms17 uc008ztc.1 uc008ztc.2 uc008ztc.3 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uS17 family. RNA binding structural constituent of ribosome mitochondrion mitochondrial small ribosomal subunit ribosome translation rRNA binding mitochondrial translation uc008ztc.1 uc008ztc.2 uc008ztc.3 
ENSMUST00000119581.7 Thsd7a ENSMUST00000119581.7 thrombospondin, type I, domain containing 7A (from RefSeq NM_001164805.1) E9Q6P0 E9QNR5 E9QNR5_MOUSE ENSMUST00000119581.1 ENSMUST00000119581.2 ENSMUST00000119581.3 ENSMUST00000119581.4 ENSMUST00000119581.5 ENSMUST00000119581.6 NM_001164805 Thsd7a uc033ioe.1 uc033ioe.2 uc033ioe.3 plasma membrane membrane integral component of membrane uc033ioe.1 uc033ioe.2 uc033ioe.3 
ENSMUST00000119590.2 Gm2030 ENSMUST00000119590.2 predicted gene 2030 (from RefSeq NM_001100445.2) D3Z7C4 D3Z7C4_MOUSE ENSMUST00000119590.1 Gm2030 NM_001100445 uc009svj.1 uc009svj.2 uc009svj.3 uc009svj.4 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc009svj.1 uc009svj.2 uc009svj.3 uc009svj.4 
ENSMUST00000119597.8 Slc18b1 ENSMUST00000119597.8 solute carrier family 18, subfamily B, member 1, transcript variant 1 (from RefSeq NM_183116.3) 1110021L09Rik E9PU92 E9PU92_MOUSE ENSMUST00000119597.1 ENSMUST00000119597.2 ENSMUST00000119597.3 ENSMUST00000119597.4 ENSMUST00000119597.5 ENSMUST00000119597.6 ENSMUST00000119597.7 NM_183116 Slc18b1 uc007eqa.1 uc007eqa.2 uc007eqa.3 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein integral component of plasma membrane membrane integral component of membrane transmembrane transport uc007eqa.1 uc007eqa.2 uc007eqa.3 
ENSMUST00000119627.8 Crybb3 ENSMUST00000119627.8 crystallin, beta B3, transcript variant 1 (from RefSeq NM_021352.3) CRBB3_MOUSE ENSMUST00000119627.1 ENSMUST00000119627.2 ENSMUST00000119627.3 ENSMUST00000119627.4 ENSMUST00000119627.5 ENSMUST00000119627.6 ENSMUST00000119627.7 NM_021352 Q9JJU9 uc012ebm.1 uc012ebm.2 Crystallins are the dominant structural components of the vertebrate eye lens. Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity). Has a two-domain beta-structure, folded into four very similar Greek key motifs. Belongs to the beta/gamma-crystallin family. lens development in camera-type eye structural constituent of eye lens visual perception uc012ebm.1 uc012ebm.2 
ENSMUST00000119649.2 Gm14525 ENSMUST00000119649.2 predicted gene 14525 (from RefSeq NM_001162364.2) B1AZA0 B1AZA0_MOUSE ENSMUST00000119649.1 Gm14525 NM_001162364 uc009svk.1 uc009svk.2 uc009svk.3 uc009svk.4 uc009svk.5 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc009svk.1 uc009svk.2 uc009svk.3 uc009svk.4 uc009svk.5 
ENSMUST00000119654.2 Pdpn ENSMUST00000119654.2 podoplanin, transcript variant 2 (from RefSeq NM_001290822.1) A8Y5F6 A8Y5F6_MOUSE ENSMUST00000119654.1 NM_001290822 Pdpn uc056zyi.1 uc056zyi.2 uc056zyi.3 membrane integral component of membrane uc056zyi.1 uc056zyi.2 uc056zyi.3 
ENSMUST00000119664.2 Mapk1ip1 ENSMUST00000119664.2 Involved in the maintenance of the spindle integrity during the cytostatic factor (CSF) arrest of oocytes. (from UniProt Q9D7G9) BC055699 ENSMUST00000119664.1 MISS_MOUSE Miss Q7M749 Q9D7G9 uc033jcp.1 uc033jcp.2 uc033jcp.3 Involved in the maintenance of the spindle integrity during the cytostatic factor (CSF) arrest of oocytes. Interacts with MAPK1. Cytoplasm Cytoplasm, cytoskeleton, spindle Note=Colocalizes with the spindle at discrete sites during the second meiotic division. Expressed in ovaries and immature oocytes and two cell stage embryos, then, it disappears. It is unstable during the first meiotic division and accumulates only during the second meiotic division. Phosphorylated in vitro by MAPK1. Belongs to the MISS family. cellular_component cytoplasm spindle cytoskeleton multicellular organism development biological_process identical protein binding meiotic cell cycle uc033jcp.1 uc033jcp.2 uc033jcp.3 
ENSMUST00000119694.3 Ctsf ENSMUST00000119694.3 cathepsin F (from RefSeq NM_019861.2) CATF_MOUSE ENSMUST00000119694.1 ENSMUST00000119694.2 NM_019861 Q9R013 Q9WUT4 uc008gbc.1 uc008gbc.2 uc008gbc.3 Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Reaction=The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L.; EC=3.4.22.41; Lysosome. Belongs to the peptidase C1 family. cysteine-type endopeptidase activity extracellular space lysosome proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity proteolysis involved in cellular protein catabolic process uc008gbc.1 uc008gbc.2 uc008gbc.3 
ENSMUST00000119705.8 Depdc5 ENSMUST00000119705.8 DEP domain containing 5, transcript variant 17 (from RefSeq NM_001404336.1) DEPD5_MOUSE Depdc5 E9Q5J2 E9Q5Y0 ENSMUST00000119705.1 ENSMUST00000119705.2 ENSMUST00000119705.3 ENSMUST00000119705.4 ENSMUST00000119705.5 ENSMUST00000119705.6 ENSMUST00000119705.7 Kiaa0645 NM_001404336 P61460 uc008xae.1 uc008xae.2 uc008xae.3 uc008xae.4 As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:31548394). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (By similarity). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (By similarity). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (By similarity). However, it does not execute the GAP activity, which is mediated by NPRL2 (By similarity). Within the GATOR complex, component of the GATOR1 subcomplex, made of DEPDC5, NPRL2 and NPRL3. GATOR1 mediates the strong interaction of the GATOR complex with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) heterodimers. GATOR1 interacts with GPR155/LYCHOS; interaction takes place in presence of cholesterol and prevents interaction between GATOR1 and KICSTOR. Interacts with BMT2/SAMTOR; interaction is direct and takes place in presence of methionine, leading to inhibit the activity of the GATOR1 complex. Lysosome membrane Cytoplasm, cytosol Cytoplasm, perinuclear region Note=Localization to lysosomes is mediated by the KICSTOR complex and is amino acid- independent. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P61460-1; Sequence=Displayed; Name=2; IsoId=P61460-2; Sequence=VSP_046542; Expressed at low levels in all brain regions. Expressed throughout brain development, including in midgestation embryonic head (11.5 dpc), neonatal brain and whole adult brain. Present in neurons and absent in non-neuronal cells, including astrocytes (at protein level). The DEP domain mediates the interaction with KLHL22. Phosphorylation at Ser-992 and Ser-1518 by AKT1 and PIM1 inhibit the activity of DEPDC5, releasing inhibition of the mTORC1 pathway. Ubiquitinated. Amino acid-induced 'Lys-48'-linked polyubiquitination of DEPDC5 by the BCR(KLHL22) ubiquitin ligase complex leads to DEPDC5 proteasomal degradation and inhibition of the GATOR1 complex. Ubiquitination may occur at multiple lysines. Belongs to the IML1 family. Sequence=BAC97990.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; GTPase activator activity cytoplasm lysosome lysosomal membrane cytosol membrane negative regulation of TOR signaling cellular response to amino acid starvation intracellular signal transduction positive regulation of GTPase activity macromolecular complex binding perinuclear region of cytoplasm negative regulation of TORC1 signaling Iml1 complex Cul3-RING ubiquitin ligase complex uc008xae.1 uc008xae.2 uc008xae.3 uc008xae.4 
ENSMUST00000119706.8 Plekha8 ENSMUST00000119706.8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8, transcript variant 1 (from RefSeq NM_001164361.1) ENSMUST00000119706.1 ENSMUST00000119706.2 ENSMUST00000119706.3 ENSMUST00000119706.4 ENSMUST00000119706.5 ENSMUST00000119706.6 ENSMUST00000119706.7 Fapp2 NM_001164361 PKHA8_MOUSE Q80W71 uc009cab.1 uc009cab.2 uc009cab.3 uc009cab.4 uc009cab.5 Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non- vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity). Homodimer. Interacts with ARF1; the interaction together with phosphatidylinositol 4-phosphate binding is required for FAPP2 GlcCer transfer ability. Golgi apparatus, trans-Golgi network membrane Membrane ; Peripheral membrane protein Note=Binds through its PH domain to PtdIns(4)P and ARF1, and subsequently localizes to TGN exit sites. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80W71-1; Sequence=Displayed; Name=2; IsoId=Q80W71-2; Sequence=VSP_028547; The PH domain of FAPPS binds the small GTPase ARF1 and phosphatidylinositol-4-phosphate (PtdIns4P) with high selectivity, and is required for recruitment of FAPPs to the trans-Golgi network (TGN). nucleoplasm cytoplasm Golgi apparatus trans-Golgi network cytosol lipid transport lipid binding membrane glycolipid transporter activity ER to Golgi ceramide transport ceramide transport glycolipid transport glycolipid binding phosphatidylinositol-4-phosphate binding ceramide binding ceramide 1-phosphate binding ceramide 1-phosphate transporter activity ceramide 1-phosphate transport uc009cab.1 uc009cab.2 uc009cab.3 uc009cab.4 uc009cab.5 
ENSMUST00000119710.3 4933405O20Rik ENSMUST00000119710.3 RIKEN cDNA 4933405O20 gene (from RefSeq NM_172901.2) ENSMUST00000119710.1 ENSMUST00000119710.2 IDHG2_MOUSE NM_172901 Q8BPC6 uc009hca.1 uc009hca.2 uc009hca.3 Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Divalent metal cations; Mn(2+) or Mg(2+). Activity higher in presence of Mn(2+) than of Mg(2+). Binds 1 Mg(2+) or Mn(2+) ion per subunit. ; The heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits can be allosterically activated by citrate (CIT) or/and ADP, and the two activators can act independently or synergistically. The heterodimer composed of IDH3A and IDH3B subunits cannot be allosterically regulated and the allosteric regulation of the heterotetramer is through the IDH3G subunit and not the IDH3B subunit. The IDH3G subunit contains the allosteric site which consists of a CIT- binding site and an ADP-binding site, and the binding of CIT and ADP causes conformational changes at the allosteric site which are transmitted to the active site in the catalytic subunit (IDH3A) through a cascade of conformational changes at the heterodimer interface, leading to stabilization of the isocitrate-binding at the active site and thus activation of the enzyme. ATP can activate the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits at low concentrations but inhibits their activities at high concentrations, whereas ATP exhibits only inhibitory effect on the heterodimer composed of IDH3A and IDH3B subunits. Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer. Mitochondrion Belongs to the isocitrate and isopropylmalate dehydrogenases family. nucleotide binding magnesium ion binding isocitrate dehydrogenase (NAD+) activity ATP binding mitochondrion tricarboxylic acid cycle isocitrate metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor metal ion binding oxidation-reduction process uc009hca.1 uc009hca.2 uc009hca.3 
ENSMUST00000119746.8 Usf3 ENSMUST00000119746.8 Usf3 (from geneSymbol) B2RUQ2 B2RUQ2_MOUSE BC141330 ENSMUST00000119746.1 ENSMUST00000119746.2 ENSMUST00000119746.3 ENSMUST00000119746.4 ENSMUST00000119746.5 ENSMUST00000119746.6 ENSMUST00000119746.7 Gm608 Usf3 uc289eua.1 uc289eua.2 negative regulation of epithelial to mesenchymal transition protein dimerization activity uc289eua.1 uc289eua.2 
ENSMUST00000119797.8 Rabgef1 ENSMUST00000119797.8 RAB guanine nucleotide exchange factor (GEF) 1, transcript variant 7 (from RefSeq NM_001403282.1) ENSMUST00000119797.1 ENSMUST00000119797.2 ENSMUST00000119797.3 ENSMUST00000119797.4 ENSMUST00000119797.5 ENSMUST00000119797.6 ENSMUST00000119797.7 NM_001403282 Q3UIW0 Q9JM13 RABX5_MOUSE Rabex5 uc008zuf.1 uc008zuf.2 uc008zuf.3 uc008zuf.4 Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A (By similarity). Can act as a ubiquitin ligase (By similarity). Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2 (By similarity). Interacts with RAB21, and with 100- fold lower affinity also with RAB22 (By similarity). Interacts with ubiquitinated EGFR (By similarity). Interacts with RGS14; the interaction is GTP-dependent. Cytoplasm Early endosome Recycling endosome Expressed in the white matter tracts of the cerebellum, the fimbria hippocampi and the corpus callosum. Monoubiquitinated. negative regulation of protein phosphorylation negative regulation of leukocyte migration DNA binding protein binding nucleolus cytoplasm endosome early endosome cytosol protein targeting to membrane endocytosis zinc ion binding protein transport protein ubiquitination Rab guanyl-nucleotide exchange factor activity Rab GTPase binding vesicle negative regulation of mast cell activation negative regulation of mast cell degranulation negative regulation of Ras protein signal transduction metal ion binding negative regulation of receptor-mediated endocytosis negative regulation of inflammatory response recycling endosome regulation of Fc receptor mediated stimulatory signaling pathway ubiquitin protein ligase activity negative regulation of interleukin-6 secretion negative regulation of Kit signaling pathway uc008zuf.1 uc008zuf.2 uc008zuf.3 uc008zuf.4 
ENSMUST00000119823.8 Gsta5 ENSMUST00000119823.8 Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16438; Evidence=; (from UniProt E9Q6L7) BC030173 E9Q6L7 E9Q6L7_MOUSE ENSMUST00000119823.1 ENSMUST00000119823.2 ENSMUST00000119823.3 ENSMUST00000119823.4 ENSMUST00000119823.5 ENSMUST00000119823.6 ENSMUST00000119823.7 Gm10639 Gsta5 uc009quc.1 uc009quc.2 uc009quc.3 Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16438; Evidence=; Belongs to the GST superfamily. Alpha family. glutathione transferase activity cytosol glutathione metabolic process xenobiotic metabolic process transferase activity uc009quc.1 uc009quc.2 uc009quc.3 
ENSMUST00000119824.8 1700016H13Rik ENSMUST00000119824.8 1700016H13Rik (from geneSymbol) BC049644 CD036_MOUSE ENSMUST00000119824.1 ENSMUST00000119824.2 ENSMUST00000119824.3 ENSMUST00000119824.4 ENSMUST00000119824.5 ENSMUST00000119824.6 ENSMUST00000119824.7 Q9DAA3 uc290xqa.1 uc290xqa.2 molecular_function cellular_component biological_process uc290xqa.1 uc290xqa.2 
ENSMUST00000119838.9 Gm14322 ENSMUST00000119838.9 predicted gene 14322, transcript variant 1 (from RefSeq NM_001243903.1) A2AW66 A2AW66_MOUSE ENSMUST00000119838.1 ENSMUST00000119838.2 ENSMUST00000119838.3 ENSMUST00000119838.4 ENSMUST00000119838.5 ENSMUST00000119838.6 ENSMUST00000119838.7 ENSMUST00000119838.8 Gm14322 NM_001243903 uc290dgl.1 uc290dgl.2 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc290dgl.1 uc290dgl.2 
ENSMUST00000119870.9 Cngb1 ENSMUST00000119870.9 cyclic nucleotide gated channel beta 1, transcript variant 1 (from RefSeq NM_001195413.1) Cngb1 E1AZ71 E1AZ71_MOUSE ENSMUST00000119870.1 ENSMUST00000119870.2 ENSMUST00000119870.3 ENSMUST00000119870.4 ENSMUST00000119870.5 ENSMUST00000119870.6 ENSMUST00000119870.7 ENSMUST00000119870.8 NM_001195413 uc009myb.1 uc009myb.2 uc009myb.3 uc009myb.4 Membrane ; Multi- pass membrane protein photoreceptor outer segment retina homeostasis intracellular cyclic nucleotide activated cation channel activity intracellular cAMP activated cation channel activity intracellular cGMP activated cation channel activity plasma membrane cation transport visual perception phototransduction sensory perception of smell membrane integral component of membrane intracellular cyclic nucleotide activated cation channel complex cGMP binding protein localization to organelle photoreceptor cell outer segment organization terminal bouton cyclic nucleotide-gated ion channel activity photoreceptor cell maintenance detection of light stimulus involved in visual perception protein heterotetramerization regulation of cytosolic calcium ion concentration cation transmembrane transport transmembrane transporter complex uc009myb.1 uc009myb.2 uc009myb.3 uc009myb.4 
ENSMUST00000119878.8 Dyrk1a ENSMUST00000119878.8 dual-specificity tyrosine phosphorylation regulated kinase 1a, transcript variant 1 (from RefSeq NM_007890.2) DYR1A_MOUSE Dyrk ENSMUST00000119878.1 ENSMUST00000119878.2 ENSMUST00000119878.3 ENSMUST00000119878.4 ENSMUST00000119878.5 ENSMUST00000119878.6 ENSMUST00000119878.7 NM_007890 Q61214 uc008abg.1 uc008abg.2 uc008abg.3 uc008abg.4 Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:18938227, PubMed:20123978). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (By similarity). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (By similarity). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (By similarity). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (By similarity). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (By similarity). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro- survival function and negatively regulates the apoptotic process (PubMed:20167603). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (PubMed:20167603). This in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (PubMed:18938227). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1; Evidence=; Reaction=[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho- [DNA-directed RNA polymerase]; Xref=Rhea:RHEA:10216, Rhea:RHEA- COMP:11321, Rhea:RHEA-COMP:11322, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.23; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10217; Evidence=; Inhibited by RANBP9. Interacts with RANBP9 (By similarity). Interacts with RAD54L2/ARIP4 (PubMed:15199138). Interacts with WDR68 (By similarity). Interacts with CRY2 (PubMed:20123978). Interacts with SIRT1 (PubMed:20167603). Q61214; Q9ERC8: Dscam; NbExp=2; IntAct=EBI-80344, EBI-1798601; Q61214; Q61214: Dyrk1a; NbExp=2; IntAct=EBI-80344, EBI-80344; Q61214; Q9JHG6: Rcan1; NbExp=2; IntAct=EBI-80344, EBI-644061; Q61214; Q923E4: Sirt1; NbExp=4; IntAct=EBI-80344, EBI-1802585; Q61214; P53805-2: RCAN1; Xeno; NbExp=5; IntAct=EBI-80344, EBI-1541912; Nucleus speckle Detected in brain (at protein level) (PubMed:22998443). Expressed in a variety of embryonic and adult tissues (PubMed:8975710). Expressed abundantly in neurons of the brain, spinal cord, and retina in developing embryos (PubMed:8975710). Expressed in the entorhinal, temporal and visual cortices and the hippocampus of the brain where is colocalizes with SEPTIN4 (PubMed:18938227). Expressed and extensively colocalizes with SEPTIN4 in apical dendrites of pyramidal cells (PubMed:18938227). Also expressed in Purkinje cells in the cerebellum in postnatal day 1 and adult mice (PubMed:18938227). The polyhistidine repeats act as targeting signals to nuclear speckles. The histidine-rich domain (HRD) region is intrinsically disordered and promotes the formation of phase-separated liquid droplets that enhance its ability to phosphorylate the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro) (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. nucleotide binding regulation of alternative mRNA splicing, via spliceosome transcription coactivator activity actin binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding nucleus cytoplasm cytoskeleton protein phosphorylation circadian rhythm cytoskeletal protein binding tubulin binding kinase activity phosphorylation nuclear speck transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation axon dendrite negative regulation of microtubule polymerization positive regulation of RNA splicing beta-amyloid formation peptidyl-tyrosine autophosphorylation identical protein binding negative regulation of DNA damage response, signal transduction by p53 class mediator protein self-association positive regulation of transcription, DNA-templated protein autophosphorylation negative regulation of mRNA splicing, via spliceosome tau protein binding positive regulation of protein deacetylation ribonucleoprotein complex microtubule neurofilament actin filament uc008abg.1 uc008abg.2 uc008abg.3 uc008abg.4 
ENSMUST00000119901.9 Cdkn1a ENSMUST00000119901.9 cyclin dependent kinase inhibitor 1A, transcript variant 2 (from RefSeq NM_001111099.2) Cdkn1a ENSMUST00000119901.1 ENSMUST00000119901.2 ENSMUST00000119901.3 ENSMUST00000119901.4 ENSMUST00000119901.5 ENSMUST00000119901.6 ENSMUST00000119901.7 ENSMUST00000119901.8 NM_001111099 Q564P6 Q564P6_MOUSE uc012aom.1 uc012aom.2 uc012aom.3 uc012aom.4 This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at the G1 pahse. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Belongs to the CDI family. G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle cyclin-dependent protein kinase holoenzyme complex protein kinase inhibitor activity cyclin-dependent protein serine/threonine kinase inhibitor activity nucleus nucleoplasm nucleolus cytoplasm cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest cell cycle arrest Ras protein signal transduction regulation of mitotic cell cycle negative regulation of cell proliferation response to toxic substance response to organic substance response to X-ray response to organonitrogen compound positive regulation of cell death response to organic cyclic compound kinase activity phosphorylation nuclear body protein kinase binding cyclin-dependent protein kinase activating kinase activity negative regulation of cell growth animal organ regeneration ubiquitin protein ligase binding cellular response to extracellular stimulus macromolecular complex cellular response to amino acid starvation cellular response to heat negative regulation of phosphorylation response to drug negative regulation of apoptotic process macromolecular complex binding negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of protein kinase activity response to arsenic-containing substance positive regulation of fibroblast proliferation perinuclear region of cytoplasm response to glucocorticoid response to corticosterone response to hyperoxia intestinal epithelial cell maturation PCNA-p21 complex cellular response to ionizing radiation signal transduction by p53 class mediator cellular senescence replicative senescence negative regulation of cyclin-dependent protein kinase activity positive regulation of cyclin-dependent protein kinase activity negative regulation of vascular smooth muscle cell proliferation negative regulation of G1/S transition of mitotic cell cycle positive regulation of reactive oxygen species metabolic process uc012aom.1 uc012aom.2 uc012aom.3 uc012aom.4 
ENSMUST00000119943.8 Sacs ENSMUST00000119943.8 sacsin, transcript variant 1 (from RefSeq NM_015788.2) E9QNY8 E9QNY8_MOUSE ENSMUST00000119943.1 ENSMUST00000119943.2 ENSMUST00000119943.3 ENSMUST00000119943.4 ENSMUST00000119943.5 ENSMUST00000119943.6 ENSMUST00000119943.7 NM_015788 Sacs uc288uzw.1 uc288uzw.2 uc288uzw.1 uc288uzw.2 
ENSMUST00000119944.8 Lemd3 ENSMUST00000119944.8 LEM domain containing 3 (from RefSeq NM_001081193.2) E9QP59 E9QP59_MOUSE ENSMUST00000119944.1 ENSMUST00000119944.2 ENSMUST00000119944.3 ENSMUST00000119944.4 ENSMUST00000119944.5 ENSMUST00000119944.6 ENSMUST00000119944.7 Lemd3 NM_001081193 uc007hfi.1 uc007hfi.2 uc007hfi.3 angiogenesis nucleic acid binding nuclear inner membrane nucleus organization membrane integral component of membrane negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway nuclear membrane negative regulation of activin receptor signaling pathway regulation of intracellular signal transduction uc007hfi.1 uc007hfi.2 uc007hfi.3 
ENSMUST00000119945.8 Mrps10 ENSMUST00000119945.8 mitochondrial ribosomal protein S10, transcript variant 1 (from RefSeq NM_001146212.1) ENSMUST00000119945.1 ENSMUST00000119945.2 ENSMUST00000119945.3 ENSMUST00000119945.4 ENSMUST00000119945.5 ENSMUST00000119945.6 ENSMUST00000119945.7 G5E8U5 G5E8U5_MOUSE Mrps10 NM_001146212 uc008cuy.1 uc008cuy.2 uc008cuy.3 uc008cuy.4 Mitochondrion Belongs to the universal ribosomal protein uS10 family. structural constituent of ribosome mitochondrial small ribosomal subunit ribosome translation uc008cuy.1 uc008cuy.2 uc008cuy.3 uc008cuy.4 
ENSMUST00000119946.8 Pus7 ENSMUST00000119946.8 pseudouridylate synthase 7, transcript variant 3 (from RefSeq NM_178403.5) B7ZNL8 ENSMUST00000119946.1 ENSMUST00000119946.2 ENSMUST00000119946.3 ENSMUST00000119946.4 ENSMUST00000119946.5 ENSMUST00000119946.6 ENSMUST00000119946.7 F7AC41 Kiaa1897 NM_178403 PUS7_MOUSE Pus7 Q3TUC7 Q3UQN6 Q69Z76 Q91VU7 uc008wqo.1 uc008wqo.2 uc008wqo.3 uc008wqo.4 Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types. Reaction=a uridine in tRNA = a pseudouridine in tRNA; Xref=Rhea:RHEA:54572, Rhea:RHEA-COMP:13339, Rhea:RHEA-COMP:13934, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Reaction=uridine(13) in tRNA = pseudouridine(13) in tRNA; Xref=Rhea:RHEA:42540, Rhea:RHEA-COMP:10105, Rhea:RHEA-COMP:10106, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Reaction=a uridine in mRNA = a pseudouridine in mRNA; Xref=Rhea:RHEA:56644, Rhea:RHEA-COMP:14658, Rhea:RHEA-COMP:14659, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence=; Interacts with SIRT1. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VU7-1; Sequence=Displayed; Name=2; IsoId=Q91VU7-2; Sequence=VSP_059623; Belongs to the pseudouridine synthase TruD family. Sequence=BAD32568.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE25003.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; pseudouridine synthesis RNA binding nucleus tRNA processing RNA modification pseudouridine synthase activity isomerase activity negative regulation of translation enzyme binding tRNA pseudouridine synthesis regulation of hematopoietic stem cell differentiation mRNA pseudouridine synthesis regulation of mesoderm development uc008wqo.1 uc008wqo.2 uc008wqo.3 uc008wqo.4 
ENSMUST00000119953.2 Rsl1d1 ENSMUST00000119953.2 ribosomal L1 domain containing 1 (from RefSeq NM_025546.2) ENSMUST00000119953.1 NM_025546 Q8BVY0 Q8K235 RL1D1_MOUSE Rsl1d1 uc007yfb.1 uc007yfb.2 uc007yfb.3 Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. Interacts with ING1 (By similarity). Interacts with KPNA7 and KPNA2 (By similarity). Nucleus, nucleolus Belongs to the universal ribosomal protein uL1 family. Highly divergent. Sequence=AAH34355.1; Type=Frameshift; Evidence=; maturation of LSU-rRNA RNA binding mRNA 3'-UTR binding protein binding nucleus nucleolus 90S preribosome regulation of protein localization regulation of apoptotic process mRNA 5'-UTR binding regulation of cellular senescence uc007yfb.1 uc007yfb.2 uc007yfb.3 
ENSMUST00000119954.9 Pcf11 ENSMUST00000119954.9 PCF11 cleavage and polyadenylation factor subunit (from RefSeq NM_029078.3) B2RX07 ENSMUST00000119954.1 ENSMUST00000119954.2 ENSMUST00000119954.3 ENSMUST00000119954.4 ENSMUST00000119954.5 ENSMUST00000119954.6 ENSMUST00000119954.7 ENSMUST00000119954.8 F6UFZ5 G3X9Z4 KIAA0824 NM_029078 PCF11_MOUSE Pcf11 Q3TT32 Q3TTQ0 Q69ZY3 Q8K0S1 Q8R2P5 Q99KH9 uc009iic.1 uc009iic.2 uc009iic.3 uc009iic.4 Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. Associates with the phosphorylated CTD domain of POLR2A /RNA polymerase II. Nucleus Phosphorylation at Ser-120 and/or Thr-121 by WNK1 weakens its association with POLR2A/RNA polymerase II, promoting transcript release from the chromatin template and mRNA export to the cytoplasm. Sequence=AAH30492.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAD32313.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE36275.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE36493.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA polymerase II core binding mRNA binding nucleoplasm cytoplasm mitochondrion mRNA cleavage factor complex termination of RNA polymerase II transcription mRNA polyadenylation uc009iic.1 uc009iic.2 uc009iic.3 uc009iic.4 
ENSMUST00000119958.3 Cyp4a30b ENSMUST00000119958.3 cytochrome P450, family 4, subfamily a, polypeptide 30b (from RefSeq NM_001100185.1) A0A087WS15 A0A087WS15_MOUSE Cyp4a30b ENSMUST00000119958.1 ENSMUST00000119958.2 NM_001100185 uc008uet.1 uc008uet.2 Belongs to the cytochrome P450 family. molecular_function monooxygenase activity iron ion binding cellular_component biological_process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc008uet.1 uc008uet.2 
ENSMUST00000119965.3 Rhox3g ENSMUST00000119965.3 reproductive homeobox 3G (from RefSeq NM_001145406.3) B9EJQ9 B9EJQ9_MOUSE ENSMUST00000119965.1 ENSMUST00000119965.2 NM_001145406 Rhox3g Rhox3g-ps uc012hgg.1 uc012hgg.2 uc012hgg.3 uc012hgg.4 This gene is a member of the reproductive homeobox X-linked family (Rhox), which forms part of the superfamily of Homeobox transcription factors. Rhox family members are thought to contribute to early embryo development as well as female and male gametogenesis because they are expressed during embryogenesis and in reproductive tissues. In the mouse, this family expanded to form gene clusters categorized into alpha, beta and gamma, depending on chromosomal locations. Rhox3 paralogs are in the alpha cluster and are reported to be more highly expressed in testes compared to ovaries. This protein is missing a portion of the N-terminus compared to other Rhox3 paralogs, so its functional capacity is unclear. [provided by RefSeq, Dec 2012]. ##Evidence-Data-START## Transcript exon combination :: BC147475.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Nucleus molecular_function DNA binding cellular_component nucleus biological_process uc012hgg.1 uc012hgg.2 uc012hgg.3 uc012hgg.4 
ENSMUST00000119970.8 Kcnmb2 ENSMUST00000119970.8 potassium large conductance calcium-activated channel, subfamily M, beta member 2 (from RefSeq NM_028231.3) ENSMUST00000119970.1 ENSMUST00000119970.2 ENSMUST00000119970.3 ENSMUST00000119970.4 ENSMUST00000119970.5 ENSMUST00000119970.6 ENSMUST00000119970.7 KCMB2_MOUSE NM_028231 Q9CZM9 uc008owa.1 uc008owa.2 Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity). Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer (By similarity). Membrane ; Multi-pass membrane protein The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus (By similarity). N-glycosylated. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily. action potential potassium channel activity detection of calcium ion integral component of plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex calcium-activated potassium channel activity potassium channel regulator activity membrane integral component of membrane neuronal action potential potassium ion transmembrane transport uc008owa.1 uc008owa.2 
ENSMUST00000119972.4 Dnajb3 ENSMUST00000119972.4 DnaJ heat shock protein family (Hsp40) member B3 (from RefSeq NM_008299.3) Dnajb3 ENSMUST00000119972.1 ENSMUST00000119972.2 ENSMUST00000119972.3 NM_008299 Q5RL26 Q5RL26_MOUSE uc007byj.1 uc007byj.2 uc007byj.3 uc007byj.4 uc007byj.1 uc007byj.2 uc007byj.3 uc007byj.4 
ENSMUST00000119973.3 Xkr6 ENSMUST00000119973.3 X-linked Kx blood group related 6 (from RefSeq NM_173393.2) E9Q6C8 ENSMUST00000119973.1 ENSMUST00000119973.2 G3X9Y8 NM_173393 Q5GH65 Q8R1I8 XKR6_MOUSE Xkr6 uc007uhu.1 uc007uhu.2 uc007uhu.3 uc007uhu.4 uc007uhu.5 Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=E9Q6C8-1; Sequence=Displayed; Name=2; IsoId=E9Q6C8-2; Sequence=VSP_042406; Name=3; IsoId=E9Q6C8-3; Sequence=VSP_042407; Belongs to the XK family. molecular_function plasma membrane membrane integral component of membrane engulfment of apoptotic cell phosphatidylserine exposure on apoptotic cell surface apoptotic process involved in development uc007uhu.1 uc007uhu.2 uc007uhu.3 uc007uhu.4 uc007uhu.5 
ENSMUST00000119976.8 Ankle1 ENSMUST00000119976.8 ankyrin repeat and LEM domain containing 1, transcript variant 1 (from RefSeq NM_172756.3) A6H5W1 A8VU90 ANKL1_MOUSE Ankle1 Ankrd41 ENSMUST00000119976.1 ENSMUST00000119976.2 ENSMUST00000119976.3 ENSMUST00000119976.4 ENSMUST00000119976.5 ENSMUST00000119976.6 ENSMUST00000119976.7 G5E8T1 Lem3 NM_172756 Q8C4V5 Q8K2N6 uc009mdd.1 uc009mdd.2 uc009mdd.3 uc009mdd.4 uc009mdd.5 Endonuclease that probably plays a role in the DNA damage response and DNA repair. Interacts (via LEM domain) with BANF1; the interaction may favor BANF1 dimerization. Cytoplasm Nucleus Note=At the steady state, predominantly localizes in the cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=A8VU90-1; Sequence=Displayed; Name=2 ; IsoId=A8VU90-2; Sequence=VSP_058615; Predominantly expressed in bone marrow, spleen, thymus, colon and ovary. Expressed also to a lesser extent in lymph nodes, liver and testis. The LEM domain is required for GIY-YIG domain-mediated DNA cleavage and induction of DNA damage response. No visible phenotype. No defect in T cell, B cell and erythrocyte development. Normal percentage of common myeloid precursors (CMP) and common lymphoid precursors (CLP) in the bone marrow. Sequence=AAH30436.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC38015.1; Type=Frameshift; Evidence=; Sequence=BAC38015.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; nuclease activity endonuclease activity nucleus cytoplasm protein export from nucleus cellular response to DNA damage stimulus hydrolase activity negative regulation of mitotic recombination nucleic acid phosphodiester bond hydrolysis regulation of myeloid progenitor cell differentiation regulation of lymphoid progenitor cell differentiation positive regulation of response to DNA damage stimulus DNA repair determination of adult lifespan regulation of T cell differentiation in thymus erythrocyte maturation regulation of B cell differentiation regulation of alpha-beta T cell differentiation regulation of response to DNA damage stimulus uc009mdd.1 uc009mdd.2 uc009mdd.3 uc009mdd.4 uc009mdd.5 
ENSMUST00000119996.3 Dnmt3c ENSMUST00000119996.3 DNA methyltransferase 3C (from RefSeq NM_001425047.1) A0A286YDX7 DNM3C_MOUSE Dnmt3c ENSMUST00000119996.1 ENSMUST00000119996.2 Gm14490 NM_001425047 P0DOY1 uc290bnb.1 uc290bnb.2 DNA methyltransferase that specifically methylates the promoters of evolutionarily young retrotransposons in the male germline (PubMed:27856912, PubMed:28854222). De novo methylation and subsequent repression of transposable elements prevents their mobilization, which is essential for germline integrity (PubMed:27856912, PubMed:28854222). Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5- methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37; Evidence= Interacts with SPOCD1. Nucleus Specifically expressed in testis. Expression peaks around 16.5 dpc, when de novo methylation takes place in male germline. Mice are viable and healthy but show male sterility due to defects in spermatogenesis (PubMed:27856912). Male mice show hypogonadism and azoospermia with interruption of spermatogenesis at the pachytene stage of meiosis I (PubMed:27856912). Retrotransposons are derepressed due to DNA demethylation (PubMed:27856912). Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. Evolved via a duplication of Dnmt3B and was initially annotated as a pseudogene. Name=Protein Spotlight; Note=Best left unsaid - Issue 207 of September 2018; URL="https://web.expasy.org/spotlight/back_issues/207/"; DNA binding DNA (cytosine-5-)-methyltransferase activity nucleus synapsis male meiosis I spermatogenesis methyltransferase activity negative regulation of transposition transferase activity cell differentiation methylation DNA methylation on cytosine DNA methylation involved in gamete generation metal ion binding DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates C-5 methylation of cytosine uc290bnb.1 uc290bnb.2 
ENSMUST00000120004.8 Zfp607b ENSMUST00000120004.8 zinc finger protein 607B, transcript variant 2 (from RefSeq NM_198417.2) ENSMUST00000120004.1 ENSMUST00000120004.2 ENSMUST00000120004.3 ENSMUST00000120004.4 ENSMUST00000120004.5 ENSMUST00000120004.6 ENSMUST00000120004.7 G3X9H3 G3X9H3_MOUSE NM_198417 Zfp607b uc009fwy.1 uc009fwy.2 uc009fwy.3 uc009fwy.4 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc009fwy.1 uc009fwy.2 uc009fwy.3 uc009fwy.4 
ENSMUST00000120006.8 Zfp112 ENSMUST00000120006.8 zinc finger protein 112, transcript variant 6 (from RefSeq NM_001420125.1) D3Z7D1 E9QP25 ENSMUST00000120006.1 ENSMUST00000120006.2 ENSMUST00000120006.3 ENSMUST00000120006.4 ENSMUST00000120006.5 ENSMUST00000120006.6 ENSMUST00000120006.7 NM_001420125 Q0VAW7 Q9R163 ZN112_MOUSE Znf112 uc012fff.1 uc012fff.2 uc012fff.3 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q0VAW7-1; Sequence=Displayed; Name=2 ; IsoId=Q0VAW7-2; Sequence=VSP_052946; Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding cellular_component nucleus regulation of transcription, DNA-templated metal ion binding uc012fff.1 uc012fff.2 uc012fff.3 
ENSMUST00000120016.3 Zbtb9 ENSMUST00000120016.3 zinc finger and BTB domain containing 9 (from RefSeq NM_001005916.2) ENSMUST00000120016.1 ENSMUST00000120016.2 NM_001005916 Q3U3B2 Q8CDC7 Q9CYQ0 ZBTB9_MOUSE uc008bfb.1 uc008bfb.2 uc008bfb.3 uc008bfb.4 May be involved in transcriptional regulation. Nucleus nucleic acid binding DNA binding nucleus biological_process metal ion binding uc008bfb.1 uc008bfb.2 uc008bfb.3 uc008bfb.4 
ENSMUST00000120021.5 Or4f4b ENSMUST00000120021.5 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A288CFY5) A0A288CFY5 A0A288CFY5_MOUSE ENSMUST00000120021.1 ENSMUST00000120021.2 ENSMUST00000120021.3 ENSMUST00000120021.4 Olfr1289 Olfr1293-ps Or4f4b uc008lnp.1 uc008lnp.2 uc008lnp.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008lnp.1 uc008lnp.2 uc008lnp.3 
ENSMUST00000120035.8 Mapk8ip3 ENSMUST00000120035.8 mitogen-activated protein kinase 8 interacting protein 3, transcript variant 2 (from RefSeq NM_001163447.1) ENSMUST00000120035.1 ENSMUST00000120035.2 ENSMUST00000120035.3 ENSMUST00000120035.4 ENSMUST00000120035.5 ENSMUST00000120035.6 ENSMUST00000120035.7 JIP3_MOUSE Jip3 Jsap1 NM_001163447 Q5D062 Q99KU7 Q9EQD8 Q9ESN7 Q9ESN8 Q9ESN9 Q9ESP0 Q9JLH2 Q9JLH3 Q9R0U7 Syd2 uc008azf.1 uc008azf.2 uc008azf.3 uc008azf.4 The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (PubMed:10523642, PubMed:10629060). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner (PubMed:23576431, PubMed:25944905, PubMed:28259553). Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation (PubMed:23576431, PubMed:25944905, PubMed:28259553). Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration (PubMed:23576431, PubMed:25944905, PubMed:28259553). Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (PubMed:23576431, PubMed:25944905, PubMed:28259553). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:23576431, PubMed:25944905, PubMed:28259553). Forms homo- or heterooligomeric complexes. The central region of MAPK8IP3 interacts with the C-terminal of MAPK8IP2 but not MAPK8IP1. Binds specific components of the JNK signaling pathway namely MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 to the N-terminal region, MAP2K4/MKK4 and MAP2K7/MKK7 to the central region and MAP3K11 to the C- terminal region. Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1. Pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location (PubMed:10523642, PubMed:10629060, PubMed:11238452, PubMed:11106729). Interacts with ROCK1 and this interaction is enhanced by ultraviolet-B (UVB) radiation. Interacts with SH3RF2 (By similarity). Interacts with NTRK2/TRKB and NTRK3/TRKC (PubMed:21775604). Q9ESN9; P62331: Arf6; NbExp=8; IntAct=EBI-301496, EBI-988682; Q9ESN9; P28738: Kif5c; NbExp=8; IntAct=EBI-301496, EBI-2506834; Q9ESN9; O88447: Klc1; NbExp=10; IntAct=EBI-301496, EBI-301550; Q9ESN9; O88448: Klc2; NbExp=5; IntAct=EBI-301496, EBI-301558; Q9ESN9-2; P31938: Map2k1; NbExp=3; IntAct=EBI-9549291, EBI-298860; Q9ESN9-2; P47809: Map2k4; NbExp=3; IntAct=EBI-9549291, EBI-447934; Q9ESN9-2; P53349: Map3k1; NbExp=3; IntAct=EBI-9549291, EBI-447913; Q9ESN9-2; Q61831: Mapk10; NbExp=4; IntAct=EBI-9549291, EBI-400741; Q9ESN9-2; P04049: RAF1; Xeno; NbExp=2; IntAct=EBI-9549291, EBI-365996; Cytoplasm Golgi apparatus Cytoplasmic vesicle Cell projection, growth cone Cell projection, axon Cell projection, dendrite Cytoplasm, perinuclear region Note=Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells (PubMed:10629060, PubMed:11106729). KIF5A/B/C-mediated transportation to axon tips is essential for its function in enhancing neuronal axon elongation (By similarity). Event=Alternative splicing; Named isoforms=6; Name=1c; Synonyms=3b; IsoId=Q9ESN9-1; Sequence=Displayed; Name=1a; IsoId=Q9ESN9-2; Sequence=VSP_002775, VSP_002777; Name=1b; IsoId=Q9ESN9-3; Sequence=VSP_002776, VSP_002777; Name=1d; IsoId=Q9ESN9-4; Sequence=VSP_002775; Name=3a; IsoId=Q9ESN9-5; Sequence=VSP_002778, VSP_002779; Name=1e; IsoId=Q9ESN9-6; Sequence=VSP_002776; Highly expressed throughout many regions of the brain and at lower levels in the heart, liver, lung, testes and kidney. All isoforms have been identified in the brain, isoform 1a is also expressed in the spleen and lung. Highly expressed in the brain of embryonic mice. Expression levels gradually increase from 10 dpc to postnatal day 10 (P10) (at protein level). Expressed in neurites 5 days following initiation of nerve growth factor induced differentiation. NGF withdrawal results in the down-regulation of MAPK8IP3 protein by caspase-mediated cleavage. Phosphorylation by ROCK1 is crucial for the recruitment of JNK. The cerebral cortex in the embryonic brain is a little thinner and the distribution of neurons is more disordered than that found in the wild-type littermates. Belongs to the JIP scaffold family. Sequence=AAG36931.1; Type=Erroneous initiation; Evidence=; Golgi membrane in utero embryonic development MAP-kinase scaffold activity protein binding cytoplasm smooth endoplasmic reticulum Golgi apparatus plasma membrane JNK cascade activation of JUN kinase activity axon guidance respiratory gaseous exchange protein localization JUN kinase binding post-embryonic development regulation of gene expression vesicle-mediated transport kinesin binding receptor signaling complex scaffold activity axon dendrite growth cone axolemma forebrain development axon regeneration neuron projection development cytoplasmic vesicle mitogen-activated protein kinase kinase binding mitogen-activated protein kinase kinase kinase binding cell projection neuron projection positive regulation of JUN kinase activity cell body positive regulation of neuron differentiation regulation of JNK cascade lung alveolus development perinuclear region of cytoplasm lung morphogenesis axon development anterograde axonal protein transport axon cytoplasm positive regulation of neuron migration uc008azf.1 uc008azf.2 uc008azf.3 uc008azf.4 
ENSMUST00000120052.2 Lrit1 ENSMUST00000120052.2 leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 (from RefSeq NM_146245.2) ENSMUST00000120052.1 LRIT1_MOUSE Lrrc21 NM_146245 Pal Q8BXN3 Q8K099 uc007tbr.1 uc007tbr.2 uc007tbr.3 uc007tbr.4 Possible role in phototransduction. Homodimer. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Sequence=BAC32010.1; Type=Erroneous initiation; Evidence=; molecular_function endoplasmic reticulum endoplasmic reticulum membrane biological_process membrane integral component of membrane integral component of endoplasmic reticulum membrane uc007tbr.1 uc007tbr.2 uc007tbr.3 uc007tbr.4 
ENSMUST00000120056.8 Nmral1 ENSMUST00000120056.8 NmrA-like family domain containing 1, transcript variant 2 (from RefSeq NM_001290761.1) D3YU12 D3YU12_MOUSE ENSMUST00000120056.1 ENSMUST00000120056.2 ENSMUST00000120056.3 ENSMUST00000120056.4 ENSMUST00000120056.5 ENSMUST00000120056.6 ENSMUST00000120056.7 NM_001290761 Nmral1 uc007yaf.1 uc007yaf.2 uc007yaf.3 uc007yaf.4 uc007yaf.5 Cytoplasm, perinuclear region Nucleus Belongs to the NmrA-type oxidoreductase family. uc007yaf.1 uc007yaf.2 uc007yaf.3 uc007yaf.4 uc007yaf.5 
ENSMUST00000120081.3 Or1e30 ENSMUST00000120081.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEZ7) ENSMUST00000120081.1 ENSMUST00000120081.2 Olfr390 Or1e30 Q8VEZ7 Q8VEZ7_MOUSE uc288aac.1 uc288aac.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288aac.1 uc288aac.2 
ENSMUST00000120083.8 Pomgnt1 ENSMUST00000120083.8 Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose. (from UniProt Q91X88) A2A8F8 AB053220 ENSMUST00000120083.1 ENSMUST00000120083.2 ENSMUST00000120083.3 ENSMUST00000120083.4 ENSMUST00000120083.5 ENSMUST00000120083.6 ENSMUST00000120083.7 PMGT1_MOUSE Q91X88 Q9D2H7 Q9D5D3 Q9DCN3 uc290oxn.1 uc290oxn.2 Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose. Reaction=3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl- alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha- D-mannosyl)-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:54128, Rhea:RHEA-COMP:13547, Rhea:RHEA-COMP:13802, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:137323, ChEBI:CHEBI:138067; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=The manganese ion interacts primarily with the substrate UDP-N- acetylglucosamine. ; Protein modification; protein glycosylation. Interacts with DAG1 (via O-linked mannose moiety). Interacts (via transmembrane domain) with FKTN; the interaction is direct and is required for normal location in Golgi membranes. Golgi apparatus membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q91X88-1; Sequence=Displayed; Name=2; IsoId=Q91X88-2; Sequence=VSP_014972, VSP_014973; Name=3; IsoId=Q91X88-3; Sequence=VSP_014974; Expressed at basal body and daughter centriole of photoreceptor cells (at protein level). Broadly expressed in late embryonic and early postnatal cerebellar neurons, including premigratory granule neurons of the external granule cell layer. Expression is maintained in neurons of the internal granule cell layer after migration is complete. Expressed in Purkinje cells throughout development. Expressed in Bergmann glial scaffolds used by granule cells during early posnatal radial migration. The GG-type lectin domain is known as the stem domain in POMGnT1. It mediates specific interaction with beta-linked N- acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O- alpha-D-mannosylprotein. Belongs to the glycosyltransferase 13 family. Name=Functional Glycomics Gateway - GTase; Note=POMGnT1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_594"; Golgi membrane Golgi apparatus protein glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity membrane integral component of membrane O-glycan processing transferase activity transferase activity, transferring glycosyl groups manganese ion binding integral component of Golgi membrane metal ion binding beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity uc290oxn.1 uc290oxn.2 
ENSMUST00000120087.6 Samd9l ENSMUST00000120087.6 sterile alpha motif domain containing 9-like (from RefSeq NM_010156.4) E9PX59 E9PX59_MOUSE ENSMUST00000120087.1 ENSMUST00000120087.2 ENSMUST00000120087.3 ENSMUST00000120087.4 ENSMUST00000120087.5 NM_010156 Samd9l uc009auy.1 uc009auy.2 uc009auy.3 uc009auy.4 uc009auy.5 uc009auy.6 uc009auy.1 uc009auy.2 uc009auy.3 uc009auy.4 uc009auy.5 uc009auy.6 
ENSMUST00000120095.8 Wdr31 ENSMUST00000120095.8 WD repeat domain 31, transcript variant 2 (from RefSeq NM_023597.3) ENSMUST00000120095.1 ENSMUST00000120095.2 ENSMUST00000120095.3 ENSMUST00000120095.4 ENSMUST00000120095.5 ENSMUST00000120095.6 ENSMUST00000120095.7 NM_023597 Q3URZ0 Q9D3N4 Q9JHB4 WDR31_MOUSE uc008tev.1 uc008tev.2 uc008tev.3 uc008tev.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JHB4-1; Sequence=Displayed; Name=2; IsoId=Q9JHB4-2; Sequence=VSP_010419; molecular_function cellular_component biological_process uc008tev.1 uc008tev.2 uc008tev.3 uc008tev.4 
ENSMUST00000120101.8 Pxylp1 ENSMUST00000120101.8 2-phosphoxylose phosphatase 1, transcript variant 2 (from RefSeq NM_153420.3) Acpl2 ENSMUST00000120101.1 ENSMUST00000120101.2 ENSMUST00000120101.3 ENSMUST00000120101.4 ENSMUST00000120101.5 ENSMUST00000120101.6 ENSMUST00000120101.7 NM_153420 PXYP1_MOUSE Pxylp1 Q8BHA9 Q8BZ12 uc009rcv.1 uc009rcv.2 uc009rcv.3 uc009rcv.4 Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. Reaction=3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)- beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)- beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:56512, Rhea:RHEA-COMP:12573, Rhea:RHEA- COMP:14559, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:132093, ChEBI:CHEBI:140495; Evidence=; Interacts with B3GAT3; the interaction increases the 2- phosphoxylose phosphatase activity of PXYLP1 during completion of linkage region formation in a B3GAT3-mediated manner. Golgi apparatus membrane ; Single-pass type II membrane protein Note=Colocalizes to Golgi apparatus in a B3GAT3- dependent manner. Belongs to the histidine acid phosphatase family. Golgi membrane Golgi apparatus glycosaminoglycan biosynthetic process positive regulation of heparan sulfate proteoglycan biosynthetic process membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity chondroitin sulfate proteoglycan biosynthetic process uc009rcv.1 uc009rcv.2 uc009rcv.3 uc009rcv.4 
ENSMUST00000120115.3 Cbr1b ENSMUST00000120115.3 Reaction=a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH; Xref=Rhea:RHEA:19257, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.184; Evidence=; (from UniProt A0A1B0GRG8) A0A1B0GRG8 A0A1B0GRG8_MOUSE Cbr1b ENSMUST00000120115.1 ENSMUST00000120115.2 Gm5678 uc289ggd.1 uc289ggd.2 Reaction=a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH; Xref=Rhea:RHEA:19257, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.184; Evidence=; Monomer. Cytoplasm Belongs to the short-chain dehydrogenases/reductases (SDR) family. carbonyl reductase (NADPH) activity oxidation-reduction process uc289ggd.1 uc289ggd.2 
ENSMUST00000120129.9 Prr14l ENSMUST00000120129.9 proline rich 14-like (from RefSeq NM_194340.2) C330019G07Rik E9Q7C4 E9Q7C4_MOUSE ENSMUST00000120129.1 ENSMUST00000120129.2 ENSMUST00000120129.3 ENSMUST00000120129.4 ENSMUST00000120129.5 ENSMUST00000120129.6 ENSMUST00000120129.7 ENSMUST00000120129.8 NM_194340 Prl14l Prr14l uc008wzy.1 uc008wzy.2 uc008wzy.3 uc008wzy.4 molecular_function cellular_component biological_process uc008wzy.1 uc008wzy.2 uc008wzy.3 uc008wzy.4 
ENSMUST00000120135.8 Syk ENSMUST00000120135.8 spleen tyrosine kinase, transcript variant 2 (from RefSeq NM_001198977.1) ENSMUST00000120135.1 ENSMUST00000120135.2 ENSMUST00000120135.3 ENSMUST00000120135.4 ENSMUST00000120135.5 ENSMUST00000120135.6 ENSMUST00000120135.7 NM_001198977 Q3UPF7 Q3UPF7_MOUSE Syk Sykb uc007qmz.1 uc007qmz.2 uc007qmz.3 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Cell membrane Cytoplasm, cytosol Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. nucleotide binding phosphotyrosine binding protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity integrin binding ATP binding nucleus cytoplasm protein phosphorylation protein import into nucleus leukocyte cell-cell adhesion regulation of tumor necrosis factor-mediated signaling pathway interleukin-15 receptor binding kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation neutrophil chemotaxis positive regulation of protein complex assembly positive regulation of superoxide anion generation macromolecular complex intracellular signal transduction T cell receptor complex positive regulation of tumor necrosis factor biosynthetic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of interleukin-10 biosynthetic process positive regulation of interleukin-12 biosynthetic process positive regulation of interleukin-6 biosynthetic process positive regulation of interleukin-8 biosynthetic process positive regulation of B cell differentiation regulation of sequence-specific DNA binding transcription factor activity positive regulation of killing of cells of other organism positive regulation of monocyte chemotactic protein-1 production uc007qmz.1 uc007qmz.2 uc007qmz.3 
ENSMUST00000120137.3 Or1e1 ENSMUST00000120137.3 olfactory receptor family 1 subfamily E member 1 (from RefSeq NM_146923.2) ENSMUST00000120137.1 ENSMUST00000120137.2 NM_146923 Olfr20 Olfr397 Or1e1 Q7TRX9 Q7TRX9_MOUSE uc011xyt.1 uc011xyt.2 uc011xyt.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DR065670.1, DR065671.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc011xyt.1 uc011xyt.2 uc011xyt.3 
ENSMUST00000120143.8 Tpd52 ENSMUST00000120143.8 tumor protein D52, transcript variant 5 (from RefSeq NM_009412.3) ENSMUST00000120143.1 ENSMUST00000120143.2 ENSMUST00000120143.3 ENSMUST00000120143.4 ENSMUST00000120143.5 ENSMUST00000120143.6 ENSMUST00000120143.7 NM_009412 Q545M5 Q62393 Q8CCU1 Q8K564 Q99KP8 TPD52_MOUSE uc008oov.1 uc008oov.2 uc008oov.3 Forms a homodimer or heterodimer with other members of the family. Q62393; P55327: TPD52; Xeno; NbExp=2; IntAct=EBI-782591, EBI-782581; Q62393; Q16890: TPD52L1; Xeno; NbExp=3; IntAct=EBI-782591, EBI-717470; Q62393; O43399-2: TPD52L2; Xeno; NbExp=2; IntAct=EBI-782591, EBI-782616; Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q62393-1; Sequence=Displayed; Name=2; IsoId=Q62393-2; Sequence=VSP_037379; Name=3; IsoId=Q62393-3; Sequence=VSP_037379, VSP_037380; Isoform 2 is expressed at higher levels in kidney and brain than in liver, lung, testis and heart. Within the brain, isoform 2 is highly expressed in the granular layer of the cerebellum, the cortex and the hippocampus. In embryos, isoform 2 is expressed in the epithelium of the developing intestine, stomach, olfactory epithelium, neuronal layers of the retina, salivary gland, kidney and dorsal root ganglion. Belongs to the TPD52 family. calcium ion binding protein binding cytoplasm endoplasmic reticulum positive regulation of cell proliferation B cell differentiation protein homodimerization activity synapse protein heterodimerization activity perinuclear region of cytoplasm glutamatergic synapse uc008oov.1 uc008oov.2 uc008oov.3 
ENSMUST00000120155.3 Gm13320 ENSMUST00000120155.3 Gm13320 (from geneSymbol) ENSMUST00000120155.1 ENSMUST00000120155.2 uc289tfd.1 uc289tfd.2 uc289tfd.1 uc289tfd.2 
ENSMUST00000120194.2 Vcf1 ENSMUST00000120194.2 VCP nuclear cofactor family member 1, transcript variant 2 (from RefSeq NM_138598.5) A2A6P4 A2A6P4_MOUSE D11Wsu99e ENSMUST00000120194.1 Fam104a NM_138598 Vcf1 uc007meu.1 uc007meu.2 uc007meu.3 molecular_function cellular_component biological_process uc007meu.1 uc007meu.2 uc007meu.3 
ENSMUST00000120222.8 Zfp946 ENSMUST00000120222.8 zinc finger protein 946, transcript variant 2 (from RefSeq NM_198003.3) 1300003B13Rik ENSMUST00000120222.1 ENSMUST00000120222.2 ENSMUST00000120222.3 ENSMUST00000120222.4 ENSMUST00000120222.5 ENSMUST00000120222.6 ENSMUST00000120222.7 F6VWU8 F6VWU8_MOUSE NM_198003 Zfp946 uc008art.1 uc008art.2 uc008art.3 Nucleus molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008art.1 uc008art.2 uc008art.3 
ENSMUST00000120240.8 Nfu1 ENSMUST00000120240.8 Belongs to the NifU family. (from UniProt A0A0N4SUH8) A0A0N4SUH8 A0A0N4SUH8_MOUSE AK145558 ENSMUST00000120240.1 ENSMUST00000120240.2 ENSMUST00000120240.3 ENSMUST00000120240.4 ENSMUST00000120240.5 ENSMUST00000120240.6 ENSMUST00000120240.7 Nfu1 uc009csw.1 uc009csw.2 uc009csw.3 uc009csw.4 Belongs to the NifU family. iron ion binding nucleus nucleoplasm mitochondrion cytosol iron-sulfur cluster assembly iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding uc009csw.1 uc009csw.2 uc009csw.3 uc009csw.4 
ENSMUST00000120267.9 Atg16l2 ENSMUST00000120267.9 autophagy related 16 like 2, transcript variant 1 (from RefSeq NM_001111111.1) A16L2_MOUSE D3Z653 ENSMUST00000120267.1 ENSMUST00000120267.2 ENSMUST00000120267.3 ENSMUST00000120267.4 ENSMUST00000120267.5 ENSMUST00000120267.6 ENSMUST00000120267.7 ENSMUST00000120267.8 G9M4M8 NM_001111111 Q6KAU8 Q6PAU0 uc057aiq.1 uc057aiq.2 uc057aiq.3 May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner. Homooligomer (PubMed:22082872). Heterooligomer with ATG16L2 (PubMed:22082872). Interacts with ATG5 (PubMed:22082872). Self- oligomerizes to form a 800-kDa complex composed of ATG12-ATG5 and ATG16L2 (PubMed:22082872). Interacts with RAB33B (PubMed:22082872). Cytoplasm, cytosol Note=Localizes also to discrete punctae along the ciliary axoneme. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Atg16L2 beta ; IsoId=Q6KAU8-1; Sequence=Displayed; Name=2; IsoId=Q6KAU8-2; Sequence=VSP_033906, VSP_033907; Name=3; Synonyms=Atg16L2 alpha ; IsoId=Q6KAU8-3; Sequence=VSP_060643; Widely expressed. ATG16L2-deficient mice are viable and born at Mendelian proportions. Deficient mice exhibit intact canonical autophagy. Although ATG16L2 is structurally similar to ATG16L1 and is likewise able to form a complex with the autophagy proteins ATG5 and ATG12, overexpression and knockdown studies suggest that ATG16L2 is not essential for canonical autophagy. Belongs to the WD repeat ATG16 family. Sequence=AAH60054.1; Type=Erroneous initiation; Evidence=; Sequence=BAD21359.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence=; autophagosome assembly autophagosome membrane molecular_function nucleoplasm cytoplasm autophagy protein transport negative stranded viral RNA replication uc057aiq.1 uc057aiq.2 uc057aiq.3 
ENSMUST00000120268.2 Gm1993 ENSMUST00000120268.2 predicted gene 1993 (from RefSeq NM_001102677.2) A6X8I0 A6X8I0_MOUSE ENSMUST00000120268.1 Gm1993 NM_001102677 uc009vfe.1 uc009vfe.2 uc009vfe.3 uc009vfe.4 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc009vfe.1 uc009vfe.2 uc009vfe.3 uc009vfe.4 
ENSMUST00000120269.11 Itih4 ENSMUST00000120269.11 inter alpha-trypsin inhibitor, heavy chain 4, transcript variant 1 (from RefSeq NM_018746.4) A6X935 ENSMUST00000120269.1 ENSMUST00000120269.10 ENSMUST00000120269.2 ENSMUST00000120269.3 ENSMUST00000120269.4 ENSMUST00000120269.5 ENSMUST00000120269.6 ENSMUST00000120269.7 ENSMUST00000120269.8 ENSMUST00000120269.9 ITIH4_MOUSE NM_018746 O54882 Q505P8 Q8C7G9 Q8C7K5 Q91W60 Q9DBK8 uc007svv.1 uc007svv.2 uc007svv.3 uc007svv.4 uc007svv.5 This gene encodes a member of the inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors with diverse functions as anti-apoptotic and matrix stabilizing molecules during development. This gene is predominantly expressed in the liver and the encoded protein was found to be a plasma kallikrein-sensitive glycoprotein. This gene is located in a cluster of related inter alpha trypsin inhibitor genes on chromosome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]. Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. Interacts (via C-terminus) with DNAJC1 (via SANT 2 domain). Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A6X935-1; Sequence=Displayed; Name=2; IsoId=A6X935-2; Sequence=VSP_044763; Highly expressed in liver. Weak expression in lung and heart. During mid-embryonic gestation, expressed abundantly in liver, less in heart and brain. Highest expression at day 14.5. May be O-glycosylated (By similarity). N-glycosylated. Belongs to the ITIH family. serine-type endopeptidase inhibitor activity protein binding extracellular region cytoplasm plasma membrane acute-phase response negative regulation of peptidase activity negative regulation of endopeptidase activity hyaluronan metabolic process peptidase inhibitor activity response to cytokine calcium ion binding hyaluronic acid binding uc007svv.1 uc007svv.2 uc007svv.3 uc007svv.4 uc007svv.5 
ENSMUST00000120274.8 Plekhg1 ENSMUST00000120274.8 pleckstrin homology domain containing, family G (with RhoGef domain) member 1, transcript variant 1 (from RefSeq NM_001159942.1) ENSMUST00000120274.1 ENSMUST00000120274.2 ENSMUST00000120274.3 ENSMUST00000120274.4 ENSMUST00000120274.5 ENSMUST00000120274.6 ENSMUST00000120274.7 NM_001159942 Plekhg1 Q3UX37 Q3UX37_MOUSE uc007ehm.1 uc007ehm.2 uc007ehm.3 uc007ehm.4 uc007ehm.5 molecular_function Rho guanyl-nucleotide exchange factor activity nucleus nucleoplasm biological_process regulation of Rho protein signal transduction uc007ehm.1 uc007ehm.2 uc007ehm.3 uc007ehm.4 uc007ehm.5 
ENSMUST00000120301.8 Farp2 ENSMUST00000120301.8 FERM, RhoGEF and pleckstrin domain protein 2 (from RefSeq NM_145519.2) E9QJS4 ENSMUST00000120301.1 ENSMUST00000120301.2 ENSMUST00000120301.3 ENSMUST00000120301.4 ENSMUST00000120301.5 ENSMUST00000120301.6 ENSMUST00000120301.7 FARP2_MOUSE Kiaa0793 NM_145519 Q3TAP2 Q69ZZ0 Q91VS8 uc007cec.1 uc007cec.2 uc007cec.3 uc007cec.4 Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity (PubMed:23375260, PubMed:20702777). Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11- mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion. Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding. Interacts with RAC1. Detected in adult brain, lung and testis. Detected in embryonic hippocampus and brain cortex. Up-regulated by TNFSF11. Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation. guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cytoplasm cytosol cytoskeleton cell adhesion cytoskeletal protein binding neuron remodeling Rac protein signal transduction hair cycle process osteoclast differentiation Rac guanyl-nucleotide exchange factor activity actin cytoskeleton reorganization regulation of integrin activation regulation of Rho protein signal transduction semaphorin-plexin signaling pathway podosome assembly uc007cec.1 uc007cec.2 uc007cec.3 uc007cec.4 
ENSMUST00000120303.9 Or1e16 ENSMUST00000120303.9 olfactory receptor family 1 subfamily E member 16 (from RefSeq NM_146921.2) ENSMUST00000120303.1 ENSMUST00000120303.2 ENSMUST00000120303.3 ENSMUST00000120303.4 ENSMUST00000120303.5 ENSMUST00000120303.6 ENSMUST00000120303.7 ENSMUST00000120303.8 Mor135-13 NM_146921 O1E16_MOUSE Olfr1 Or1e16 Q8VGI1 uc007kap.1 uc007kap.2 uc007kap.3 uc007kap.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DR065653.1, DR065586.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01164131 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Odorant receptor. Activated by a lily-derived aldehyde as well as other odorants. May signal through an inositol 1,4,5- trisphosphate (IP3) second messenger system (By similarity). Cell membrane ; Multi-pass membrane protein Olfactory epithelium. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007kap.1 uc007kap.2 uc007kap.3 uc007kap.4 
ENSMUST00000120306.8 Urgcp ENSMUST00000120306.8 upregulator of cell proliferation, transcript variant 7 (from RefSeq NM_001361592.1) A0PJ66 ENSMUST00000120306.1 ENSMUST00000120306.2 ENSMUST00000120306.3 ENSMUST00000120306.4 ENSMUST00000120306.5 ENSMUST00000120306.6 ENSMUST00000120306.7 NM_001361592 Q3TLI5 Q5NCI0 Q8C9K3 Q8CBP7 Q8CC98 URGCP_MOUSE Urg4 uc007hwv.1 uc007hwv.2 uc007hwv.3 May be involved in cell cycle progression through the regulation of cyclin D1 expression. Cytoplasm Nucleus Note=In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q5NCI0-1; Sequence=Displayed; Name=2 ; IsoId=Q5NCI0-2; Sequence=VSP_052800; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family. Sequence=AAH16589.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC28370.1; Type=Frameshift; Evidence=; molecular_function GTP binding nucleus cytoplasm cytosol cell cycle biological_process uc007hwv.1 uc007hwv.2 uc007hwv.3 
ENSMUST00000120314.8 Dmrtc1c2 ENSMUST00000120314.8 DMRT-like family C1c2, transcript variant 1 (from RefSeq NM_001142690.2) Dmrtc1c1 Dmrtc1c2 ENSMUST00000120314.1 ENSMUST00000120314.2 ENSMUST00000120314.3 ENSMUST00000120314.4 ENSMUST00000120314.5 ENSMUST00000120314.6 ENSMUST00000120314.7 NM_001142690 Q9D410 Q9D410_MOUSE uc009tza.1 uc009tza.2 uc009tza.3 uc009tza.4 Belongs to the DMRT family. molecular_function transcription factor activity, sequence-specific DNA binding cellular_component nucleus regulation of transcription, DNA-templated biological_process uc009tza.1 uc009tza.2 uc009tza.3 uc009tza.4 
ENSMUST00000120339.8 Inava ENSMUST00000120339.8 innate immunity activator, transcript variant 1 (from RefSeq NM_028872.4) ENSMUST00000120339.1 ENSMUST00000120339.2 ENSMUST00000120339.3 ENSMUST00000120339.4 ENSMUST00000120339.5 ENSMUST00000120339.6 ENSMUST00000120339.7 INAVA_MOUSE Inava NM_028872 Q7TN12 Q7TN27 Q8BGK3 uc007cuo.1 uc007cuo.2 uc007cuo.3 uc007cuo.4 Expressed in peripheral macrophages and intestinal myeloid- derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (By similarity). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1- dependent ARF6 activation (PubMed:29420262). Interacts with IRAK1, NOD2 and RIPK2; the interaction takes place upon PRR stimulation. Interacts with YWHAQ/14-3-3T; the interaction increases upon PRR stimulation and is required for cellular signaling pathway activation and cytokine secretion. Interacts (via N- terminal domain) with CYTH1 and CYTH2 (via their N-terminal domains). Interacts with FBXW11 and BTRC; associates with SCF E3 ubiquitin- protein ligase complexes (By similarity). Nucleus Cytoplasm Note=Translocates to the nucleus upon NOD2 stimulation. After infection with Citrobacter rodentium, mutants show significantly increased bacterial loads at day 5 compared to wild-types. They are able to control the infection by day 12 post- infection, they exhibit significantly shortened colon length. They don't have impaired cytokine response (PubMed:29420262). Mutants also exhibit impaired recovery from dextran sodium sulfate-induces colitis, they show increased body weight loss and reduced colon length (PubMed:29420262). activation of MAPK activity pattern recognition receptor signaling pathway cytokine production involved in immune response immune system process molecular_function nucleus cytoplasm positive regulation of protein ubiquitination response to peptidoglycan response to muramyl dipeptide positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of stress-activated MAPK cascade adherens junction maintenance positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response intestinal epithelial structure maintenance nucleotide-binding oligomerization domain containing 2 signaling pathway reactive oxygen species biosynthetic process uc007cuo.1 uc007cuo.2 uc007cuo.3 uc007cuo.4 
ENSMUST00000120349.8 Aktip ENSMUST00000120349.8 AKT interacting protein, transcript variant 2 (from RefSeq NM_010241.5) AKTIP_MOUSE ENSMUST00000120349.1 ENSMUST00000120349.2 ENSMUST00000120349.3 ENSMUST00000120349.4 ENSMUST00000120349.5 ENSMUST00000120349.6 ENSMUST00000120349.7 Fif Ft1 Fts NM_010241 Q3TYE3 Q64362 uc292bza.1 uc292bza.2 Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. Interacts directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts with AKT1. May interact with FHIP1A. Cytoplasm Cell membrane ; Peripheral membrane protein Ubiquitous. Highest expression in kidney, testis and brain and lowest in spleen and liver. Note=Defects in Aktip are a cause of embryonic death in homozygous animals. Death occurs at about 10 days of development. Symptoms include loss of left-right asymmetry, malformation of the developing brain and of the spinal cord, syndactyly and polydactyly. Heterozygous animals are characterized by polydactyly and thymic hyperplasia. Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily. Lacks the conserved Cys residue necessary for ubiquitin- conjugating enzyme E2 activity. positive regulation of protein phosphorylation nucleus cytoplasm cytosol plasma membrane apoptotic process cellular response to DNA damage stimulus endosome organization lysosome organization endosome to lysosome transport protein transport membrane protein ubiquitination HOPS complex positive regulation of protein binding early endosome to late endosome transport ubiquitin conjugating enzyme activity FHF complex uc292bza.1 uc292bza.2 
ENSMUST00000120381.9 Stt3a ENSMUST00000120381.9 STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) (from RefSeq NM_008408.5) ENSMUST00000120381.1 ENSMUST00000120381.2 ENSMUST00000120381.3 ENSMUST00000120381.4 ENSMUST00000120381.5 ENSMUST00000120381.6 ENSMUST00000120381.7 ENSMUST00000120381.8 Itm1 NM_008408 Q3U573 Q3U573_MOUSE Stt3a uc009oty.1 uc009oty.2 uc009oty.3 Reaction=a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N- acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L- asparaginy-[protein]; Xref=Rhea:RHEA:22980, Rhea:RHEA-COMP:9529, Rhea:RHEA-COMP:12635, Rhea:RHEA-COMP:12804, Rhea:RHEA-COMP:12805, ChEBI:CHEBI:15378, ChEBI:CHEBI:50347, ChEBI:CHEBI:57497, ChEBI:CHEBI:57570, ChEBI:CHEBI:132529; EC=2.4.99.18; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the STT3 family. oligosaccharyl transferase activity dolichyl-diphosphooligosaccharide-protein glycotransferase activity protein glycosylation membrane integral component of membrane transferase activity protein N-linked glycosylation via asparagine co-translational protein modification uc009oty.1 uc009oty.2 uc009oty.3 
ENSMUST00000120388.9 Il33 ENSMUST00000120388.9 interleukin 33, transcript variant 2 (from RefSeq NM_133775.3) ENSMUST00000120388.1 ENSMUST00000120388.2 ENSMUST00000120388.3 ENSMUST00000120388.4 ENSMUST00000120388.5 ENSMUST00000120388.6 ENSMUST00000120388.7 ENSMUST00000120388.8 IL33_MOUSE Il33 NM_133775 Q2YEJ4 Q3TQN0 Q8BVZ5 Q99L46 uc008hec.1 uc008hec.2 uc008hec.3 uc008hec.4 Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:29045903). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines (By similarity). Also involved in activation of mast cells, basophils, eosinophils and natural killer cells (By similarity). Acts as an enhancer of polarization of alternatively activated macrophages (By similarity). Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (PubMed:34644537). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (By similarity). This form is rapidely lost upon angiogenic or pro- inflammatory activation (By similarity). (Microbial infection) Interacts (in reduced form) with H.polygyrus ARI; the interaction abolishes the interaction with its primary receptor IL1RL1. Forms a 1:1:1 heterotrimeric complex with its primary high- affinity receptor IL1RL1 and the coreceptor IL1RAP. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Nucleus Chromosome Cytoplasm Cytoplasmic vesicle, secretory vesicle Secreted te=Secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore following cleavage by CELA1 (PubMed:35794369, PubMed:35749514). Associates with heterochromatin and mitotic chromosomes (By similarity). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) followed by vesicle entry and secretion (By similarity). Nucleus Note=(Microbial infection) Upon infection with H.polygyrus, tethered to the nucleus by the H.polygyrus parasitic protein ARI. By cold stress, and by infection with the fungus A.alternata and the parasite H.polygyrus. The homeodomain-like HTH domain mediates nuclear localization and heterochromatin association. The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor (PubMed:16286016). However, proteolytic processing by CELA1, CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full-length protein (PubMed:22307629, PubMed:35749514). May also be proteolytically processed by calpains. Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation (PubMed:16286016, PubMed:19465481). In vitro proteolytic cleavage by CASP1 was reported (PubMed:16286016) but could not be confirmed in vivo (PubMed:19465481) suggesting that IL33 is probably not a direct substrate for that caspase (PubMed:16286016, PubMed:19465481). Intraperitoneal injections of IL-33 induce the expression of IL-4, IL-5, and IL-13 and lead to severe pathological changes in mucosal organs. Belongs to the IL-1 family. Highly divergent. macrophage activation involved in immune response microglial cell activation involved in immune response negative regulation of leukocyte migration negative regulation of T-helper 1 type immune response positive regulation of type 2 immune response cytokine activity extracellular region extracellular space nucleus chromosome positive regulation of gene expression transport vesicle cytoplasmic vesicle positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of interferon-gamma production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production positive regulation of interleukin-6 production positive regulation of macrophage activation positive regulation of transcription from RNA polymerase II promoter positive regulation of inflammatory response positive regulation of immunoglobulin secretion negative regulation of immunoglobulin secretion defense response to virus microglial cell proliferation positive regulation of chemokine secretion extrinsic apoptotic signaling pathway uc008hec.1 uc008hec.2 uc008hec.3 uc008hec.4 
ENSMUST00000120389.8 Snx12 ENSMUST00000120389.8 sorting nexin 12, transcript variant 1 (from RefSeq NM_001110310.2) ENSMUST00000120389.1 ENSMUST00000120389.2 ENSMUST00000120389.3 ENSMUST00000120389.4 ENSMUST00000120389.5 ENSMUST00000120389.6 ENSMUST00000120389.7 NM_001110310 Q6ZWQ5 Q6ZWQ5_MOUSE Snx12 uc009tww.1 uc009tww.2 uc009tww.3 uc009tww.4 Belongs to the sorting nexin family. phosphatidylinositol binding uc009tww.1 uc009tww.2 uc009tww.3 uc009tww.4 
ENSMUST00000120394.8 Eef1ece2 ENSMUST00000120394.8 Eef1akmt4-endothelin converting enzyme 2 readthrough, transcript variant 1 (from RefSeq NM_177941.1) E9QKA6 EFCE2_MOUSE ENSMUST00000120394.1 ENSMUST00000120394.2 ENSMUST00000120394.3 ENSMUST00000120394.4 ENSMUST00000120394.5 ENSMUST00000120394.6 ENSMUST00000120394.7 Eef1akmt4-Ece2 NM_177941 P0DPD9 Q14BY3 Q80Z59 Q80Z60 Q9D8Q9 Q9D928 uc007yqi.1 uc007yqi.2 uc007yqi.3 This locus represents naturally occurring readthrough transcription between the adjacent genes eukaryotic translation elongation factor 1 alpha lysine specific methyltransferase 4 (GeneID:110599566) and endothelin converting enzyme 2 (GeneID:107522). The readthrough transcript representing this gene encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2017]. Converts big endothelin-1 to endothelin-1. May also have methyltransferase activity (By similarity). May play a role in amyloid- beta processing (PubMed:12464614). Reaction=Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.; EC=3.4.24.71; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Inhibited by phosphoramidon. Golgi apparatus membrane ; Single-pass type II membrane protein Cytoplasmic vesicle, secretory vesicle membrane Event=Alternative splicing; Named isoforms=5; Name=Eef1akmt4-Ece2-1; Synonyms=ECE-2a-1 ; IsoId=P0DPD9-1, Q80Z60-1; Sequence=Displayed; Name=Eef1akmt4-Ece2-2; Synonyms=ECE-2a-2 ; IsoId=P0DPD9-2, Q80Z60-2; Sequence=VSP_029335; Name=Eef1akmt4-1; IsoId=P0DPE0-1, Q80Z60-3; Sequence=External; Name=Ece2-1; IsoId=B2RQR8-1; Sequence=External; Name=Ece2-2; IsoId=B2RQR8-2; Sequence=External; Expressed at high levels in central nervous system. Expressed in adrenal glands, ovary and uterus, and at low levels in heart. Weakly expressed in mesenchyme and parts of neural tube at 10.5 dpc. At 13.5 dpc, expressed in anterior part of neural tube, dorsal root ganglia, bilateral sympathetic trunk and heart. Eef1akmt4-Ece2 and Ece2 double mutant mice are fertile and healthy, and do not display any abnormality in terms of growth or aging. [Isoform Eef1akmt4-Ece2-1]: Based on a naturally occurring readthrough transcript which produces an Eef1akmt4-Ece2 fusion protein. [Isoform Eef1akmt4-Ece2-2]: Based on a naturally occurring readthrough transcript which produces an Eef1akmt4-Ece2 fusion protein. In the N-terminal section; belongs to the methyltransferase superfamily. In the C-terminal section; belongs to the peptidase M13 family. Sequence=AAO72356.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAO72357.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi membrane catalytic activity metalloendopeptidase activity Golgi apparatus trans-Golgi network proteolysis brain development heart development metabolic process methyltransferase activity peptidase activity metallopeptidase activity cardioblast differentiation membrane integral component of membrane peptide hormone processing transferase activity hydrolase activity transport vesicle membrane cytoplasmic vesicle membrane cytoplasmic vesicle methylation metal ion binding uc007yqi.1 uc007yqi.2 uc007yqi.3 
ENSMUST00000120398.2 C920021L13Rik ENSMUST00000120398.2 RIKEN cDNA C920021L13 gene (from RefSeq NR_040446.1) ENSMUST00000120398.1 NR_040446 uc008qlk.1 uc008qlk.2 uc008qlk.3 uc008qlk.1 uc008qlk.2 uc008qlk.3 
ENSMUST00000120447.8 Blzf1 ENSMUST00000120447.8 basic leucine zipper nuclear factor 1, transcript variant 4 (from RefSeq NM_001357052.1) ENSMUST00000120447.1 ENSMUST00000120447.2 ENSMUST00000120447.3 ENSMUST00000120447.4 ENSMUST00000120447.5 ENSMUST00000120447.6 ENSMUST00000120447.7 GO45_MOUSE NM_001357052 Q3TJC4 Q8C0U6 Q8R2X8 Q9DAV7 uc007dii.1 uc007dii.2 uc007dii.3 uc007dii.4 Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. Interacts with GORASP2 (PubMed:11739401, PubMed:28049725). Interacts with the GTP-bound form of RAB2, but not with other Golgi Rab proteins (PubMed:11739401). Identified in a complex with RAB2 and GORASP2 (PubMed:11739401). Golgi apparatus membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R2X8-1; Sequence=Displayed; Name=2; IsoId=Q8R2X8-2; Sequence=VSP_011188; The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation. Was initially thought to be a potential transcription factor, localized in the nucleus. Golgi membrane protein binding nucleus Golgi apparatus Golgi organization protein transport membrane vesicle-mediated transport enzyme binding ubiquitin protein ligase binding Golgi to plasma membrane protein transport uc007dii.1 uc007dii.2 uc007dii.3 uc007dii.4 
ENSMUST00000120472.2 Afap1l1 ENSMUST00000120472.2 actin filament associated protein 1-like 1 (from RefSeq NM_178928.4) AF1L1_MOUSE ENSMUST00000120472.1 NM_178928 Q8BKB8 Q8BZI0 uc008fcq.1 uc008fcq.2 uc008fcq.3 May be involved in podosome and invadosome formation. Interacts with CTTN. Cytoplasm Cell projection, podosome Cell projection, invadopodium Cytoplasm, cytoskeleton, stress fiber Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZI0-1; Sequence=Displayed; Name=2; IsoId=Q8BZI0-2; Sequence=VSP_026860, VSP_026861; podosome protein binding cytoplasm cytosol cytoskeleton biological_process SH3 domain binding cell junction cell projection invadopodium uc008fcq.1 uc008fcq.2 uc008fcq.3 
ENSMUST00000120490.8 Abca16 ENSMUST00000120490.8 ATP-binding cassette, sub-family A member 16, transcript variant 2 (from RefSeq NM_001278944.1) Abca16 E9PWJ7 E9PWJ7_MOUSE ENSMUST00000120490.1 ENSMUST00000120490.2 ENSMUST00000120490.3 ENSMUST00000120490.4 ENSMUST00000120490.5 ENSMUST00000120490.6 ENSMUST00000120490.7 NM_001278944 uc291uzx.1 uc291uzx.2 Membrane ; Multi- pass membrane protein nucleotide binding lipid transporter activity ATP binding lipid transport membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances intracellular membrane-bounded organelle transmembrane transport uc291uzx.1 uc291uzx.2 
ENSMUST00000120518.4 Or4p4 ENSMUST00000120518.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1SRD7) A0A1L1SRD7 A0A1L1SRD7_MOUSE ENSMUST00000120518.1 ENSMUST00000120518.2 ENSMUST00000120518.3 Olfr1192 Or4p4 uc289xyz.1 uc289xyz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xyz.1 uc289xyz.2 
ENSMUST00000120537.8 Bcl3 ENSMUST00000120537.8 B cell leukemia/lymphoma 3 (from RefSeq NM_033601.3) BCL3_MOUSE ENSMUST00000120537.1 ENSMUST00000120537.2 ENSMUST00000120537.3 ENSMUST00000120537.4 ENSMUST00000120537.5 ENSMUST00000120537.6 ENSMUST00000120537.7 NM_033601 Q9Z2F6 uc009fnk.1 uc009fnk.2 uc009fnk.3 uc009fnk.4 Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit (By similarity). In the nucleus, acts as a transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation. Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR (By similarity). Interacts with CYLD. Q9Z2F6; Q80TQ2: Cyld; NbExp=5; IntAct=EBI-943884, EBI-943859; Nucleus Cytoplasm Cytoplasm, perinuclear region Note=Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation. Activated by phosphorylation. It is uncertain whether Met-1 or Met-9 is the initiator. Sequence=AAC79694.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; follicular dendritic cell differentiation marginal zone B cell differentiation humoral immune response mediated by circulating immunoglobulin germinal center formation DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane transcription, DNA-templated cellular response to DNA damage stimulus I-kappaB kinase/NF-kappaB signaling transcription factor binding response to virus response to UV-C antimicrobial humoral response extracellular matrix organization DNA damage response, signal transduction by p53 class mediator midbody positive regulation of interferon-gamma production macromolecular complex Bcl3-Bcl10 complex Bcl3/NF-kappaB2 complex T-helper 1 type immune response negative regulation of tumor necrosis factor biosynthetic process defense response to bacterium intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator defense response to protozoan regulation of apoptotic process negative regulation of apoptotic process intracellular membrane-bounded organelle T-helper 2 cell differentiation positive regulation of interleukin-10 biosynthetic process negative regulation of interleukin-8 biosynthetic process positive regulation of translation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JAK-STAT cascade perinuclear region of cytoplasm spleen development regulation of DNA binding regulation of NIK/NF-kappaB signaling uc009fnk.1 uc009fnk.2 uc009fnk.3 uc009fnk.4 
ENSMUST00000120539.8 Lmo4 ENSMUST00000120539.8 LIM domain only 4, transcript variant 1 (from RefSeq NM_010723.3) ENSMUST00000120539.1 ENSMUST00000120539.2 ENSMUST00000120539.3 ENSMUST00000120539.4 ENSMUST00000120539.5 ENSMUST00000120539.6 ENSMUST00000120539.7 Lmo4 NM_010723 Q542S1 Q542S1_MOUSE uc012cyw.1 uc012cyw.2 uc012cyw.3 metal ion binding uc012cyw.1 uc012cyw.2 uc012cyw.3 
ENSMUST00000120563.2 Ptger4 ENSMUST00000120563.2 prostaglandin E receptor 4 (subtype EP4), transcript variant 1 (from RefSeq NM_001136079.2) ENSMUST00000120563.1 NM_001136079 Ptger4 Q91VE4 Q91VE4_MOUSE uc007vcz.1 uc007vcz.2 uc007vcz.3 uc007vcz.4 uc007vcz.5 Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Interacts with FEM1A. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity prostaglandin receptor activity prostaglandin E receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc007vcz.1 uc007vcz.2 uc007vcz.3 uc007vcz.4 uc007vcz.5 
ENSMUST00000120573.3 Arsk ENSMUST00000120573.3 Reaction=Hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D- glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate.; EC=3.1.6.18; Evidence=; (from UniProt A0A0R4J1N2) A0A0R4J1N2 A0A0R4J1N2_MOUSE AK144817 Arsk ENSMUST00000120573.1 ENSMUST00000120573.2 uc007rgh.1 uc007rgh.2 Reaction=Hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D- glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate.; EC=3.1.6.18; Evidence=; Reaction=an aryl sulfate + H2O = a phenol + H(+) + sulfate; Xref=Rhea:RHEA:17261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:33853, ChEBI:CHEBI:140317; EC=3.1.6.1; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Belongs to the sulfatase family. catalytic activity sulfuric ester hydrolase activity uc007rgh.1 uc007rgh.2 
ENSMUST00000120580.8 Prpf39 ENSMUST00000120580.8 pre-mRNA processing factor 39, transcript variant 1 (from RefSeq NM_177806.3) E9QJV4 E9QJV4_MOUSE ENSMUST00000120580.1 ENSMUST00000120580.2 ENSMUST00000120580.3 ENSMUST00000120580.4 ENSMUST00000120580.5 ENSMUST00000120580.6 ENSMUST00000120580.7 NM_177806 Prpf39 uc007nqw.1 uc007nqw.2 uc007nqw.3 Belongs to the PRP39 family. RNA processing uc007nqw.1 uc007nqw.2 uc007nqw.3 
ENSMUST00000120585.8 Mthfd1l ENSMUST00000120585.8 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like, transcript variant 1 (from RefSeq NM_001170785.1) C1TM_MOUSE ENSMUST00000120585.1 ENSMUST00000120585.2 ENSMUST00000120585.3 ENSMUST00000120585.4 ENSMUST00000120585.5 ENSMUST00000120585.6 ENSMUST00000120585.7 Fthfsdc1 NM_001170785 Q3TVQ0 Q3V3R1 Q3V402 Q80V98 Q8CAL0 Q8K2N5 uc011wzu.1 uc011wzu.2 uc011wzu.3 May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10- formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221, ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57453, ChEBI:CHEBI:195366, ChEBI:CHEBI:456216; EC=6.3.4.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20222; Evidence=; One-carbon metabolism; tetrahydrofolate interconversion. Homodimer. Mitochondrion This monofunctional enzyme consists of two major domains: an N- terminal inactive methylene-THF dehydrogenase and cyclohydrolase domain and an active larger formyl-THF synthetase C-terminal domain. In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. Sequence=AAH30437.1; Type=Erroneous initiation; Evidence=; nucleotide binding neural tube closure formate-tetrahydrofolate ligase activity methylenetetrahydrofolate dehydrogenase (NADP+) activity ATP binding cytoplasm mitochondrion one-carbon metabolic process folic acid-containing compound metabolic process purine nucleobase biosynthetic process 10-formyltetrahydrofolate biosynthetic process formate metabolic process ligase activity tetrahydrofolate interconversion protein homodimerization activity embryonic neurocranium morphogenesis embryonic viscerocranium morphogenesis oxidation-reduction process uc011wzu.1 uc011wzu.2 uc011wzu.3 
ENSMUST00000120591.8 Pisd ENSMUST00000120591.8 phosphatidylserine decarboxylase, transcript variant 2 (from RefSeq NM_001347332.1) E9PX91 E9PX91_MOUSE ENSMUST00000120591.1 ENSMUST00000120591.2 ENSMUST00000120591.3 ENSMUST00000120591.4 ENSMUST00000120591.5 ENSMUST00000120591.6 ENSMUST00000120591.7 NM_001347332 PISD Pisd uc290ukv.1 uc290ukv.2 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2- diacyl-sn-glycero-3-phosphoethanolamine + CO2; Xref=Rhea:RHEA:20828, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57262, ChEBI:CHEBI:64612; EC=4.1.1.65; Evidence= Name=pyruvate; Xref=ChEBI:CHEBI:15361; Evidence=; Note=Binds 1 pyruvoyl group covalently per subunit. Lipid metabolism. Phospholipid metabolism; phosphatidylethanolamine biosynthesis. Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Mitochondrion inner membrane [Phosphatidylserine decarboxylase alpha chain]: Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain. [Phosphatidylserine decarboxylase beta chain]: Mitochondrion inner membrane ; Single- pass membrane protein ; Intermembrane side Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily. phosphatidylserine decarboxylase activity mitochondrion mitochondrial inner membrane lipid metabolic process phosphatidylethanolamine biosynthetic process phospholipid biosynthetic process membrane integral component of membrane protein autoprocessing lyase activity carboxy-lyase activity integral component of mitochondrial inner membrane uc290ukv.1 uc290ukv.2 
ENSMUST00000120592.2 Pvalb ENSMUST00000120592.2 parvalbumin, transcript variant 2 (from RefSeq NM_013645.4) ENSMUST00000120592.1 NM_013645 Pvalb Q545M7 Q545M7_MOUSE uc007wot.1 uc007wot.2 uc007wot.3 uc007wot.4 uc007wot.5 In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. Belongs to the parvalbumin family. calcium ion binding nucleus cytoplasm stereocilium cuticular plate macromolecular complex protein homodimerization activity neuronal cell body metal ion binding protein heterodimerization activity cochlea development uc007wot.1 uc007wot.2 uc007wot.3 uc007wot.4 uc007wot.5 
ENSMUST00000120594.8 Cadm2 ENSMUST00000120594.8 cell adhesion molecule 2, transcript variant 3 (from RefSeq NM_001347247.1) B1B1A5 B1B1A6 B2RTL0 CADM2_MOUSE ENSMUST00000120594.1 ENSMUST00000120594.2 ENSMUST00000120594.3 ENSMUST00000120594.4 ENSMUST00000120594.5 ENSMUST00000120594.6 ENSMUST00000120594.7 Igsf4d NM_001347247 Necl3 Q8BLQ9 Q8BXJ7 Q8BYP1 Q8BZP4 uc057kvt.1 uc057kvt.2 uc057kvt.3 Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity). Cell membrane ; Single-pass type I membrane protein. Synapse Cell projection, axon Note=Found in the axoplasm of myelinated axons. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BLQ9-1; Sequence=Displayed; Name=2; IsoId=Q8BLQ9-2; Sequence=VSP_026336, VSP_026337; Name=3; IsoId=Q8BLQ9-3; Sequence=VSP_026337; Glycosylation at Asn-51 reduces adhesive binding. Belongs to the nectin family. protein binding cytoplasm plasma membrane cell adhesion membrane integral component of membrane cell junction axon neuronal cell body membrane cell projection synapse uc057kvt.1 uc057kvt.2 uc057kvt.3 
ENSMUST00000120613.9 Kif3a ENSMUST00000120613.9 kinesin family member 3A, transcript variant 1 (from RefSeq NM_008443.4) ENSMUST00000120613.1 ENSMUST00000120613.2 ENSMUST00000120613.3 ENSMUST00000120613.4 ENSMUST00000120613.5 ENSMUST00000120613.6 ENSMUST00000120613.7 ENSMUST00000120613.8 KIF3A_MOUSE Kif3 NM_008443 P28741 Q7TSZ7 uc007iwl.1 uc007iwl.2 uc007iwl.3 uc007iwl.4 Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (PubMed:21670265). Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole (PubMed:23386061). Heterodimer of KIF3A and KIF3B (PubMed:7559760). Interacts with CIMAP3 (PubMed:20643351). Interacts with CLN3 (By similarity). Interacts with DCTN1 (PubMed:23386061). Interacts with FLCN (By similarity). Interacts with AP3B1 (By similarity). P28741; Q6A078: Cep290; NbExp=3; IntAct=EBI-6169413, EBI-1811999; P28741; O08788: Dctn1; NbExp=4; IntAct=EBI-6169413, EBI-776180; P28741; Q61771: Kif3b; NbExp=6; IntAct=EBI-6169413, EBI-6395332; P28741; P70188: Kifap3; NbExp=4; IntAct=EBI-6169413, EBI-6169443; P28741; Q8VI40: Trim60; NbExp=5; IntAct=EBI-6169413, EBI-6395249; Cytoplasm, cytoskeleton Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localizes to the subdistal appendage region of the centriole. Expressed almost exclusively in adult brain tissue (mainly in the cerebellar granular layer) within a single type of neuronal cell. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. nucleotide binding in utero embryonic development kidney development heart looping microtubule motor activity protein binding ATP binding cytoplasm centrosome centriole cytosol cytoskeleton kinesin complex microtubule cilium axoneme microtubule-based movement smoothened signaling pathway determination of left/right symmetry axon guidance heart development microtubule binding anterograde axonal transport epidermis development anterior/posterior pattern specification dorsal/ventral pattern formation centriole-centriole cohesion protein transport microtubule cytoskeleton ATPase activity kinesin II complex Rab GTPase binding kinesin binding protein phosphatase binding dentate gyrus development dorsal/ventral neural tube patterning neural tube development cell projection organization spectrin binding motile cilium photoreceptor connecting cilium microtubule anchoring at centrosome epidermal stem cell homeostasis cell projection neuron projection neuronal cell body motile cilium assembly macromolecular complex binding positive regulation of receptor-mediated endocytosis positive regulation of epithelial cell proliferation inner ear receptor stereocilium organization cilium assembly neural precursor cell proliferation positive regulation of intracellular protein transport ribbon synapse protein localization to cell junction axon cytoplasm positive regulation of axo-dendritic protein transport non-motile cilium assembly positive regulation of establishment or maintenance of cell polarity regulating cell shape spindle microtubule uc007iwl.1 uc007iwl.2 uc007iwl.3 uc007iwl.4 
ENSMUST00000120638.8 Syn3 ENSMUST00000120638.8 synapsin III, transcript variant 1 (from RefSeq NM_013722.3) E9QNQ6 ENSMUST00000120638.1 ENSMUST00000120638.2 ENSMUST00000120638.3 ENSMUST00000120638.4 ENSMUST00000120638.5 ENSMUST00000120638.6 ENSMUST00000120638.7 NM_013722 Q8JZP2 SYN3_MOUSE uc007gnn.1 uc007gnn.2 uc007gnn.3 uc007gnn.4 May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed (By similarity). Interacts with CAPON. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles. The A region binds phospholipids with a preference for negatively charged species. Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles. Regulated by calcium. Calcium inhibits ATP binding to the C-domain (By similarity). Belongs to the synapsin family. nucleotide binding ATP binding neurotransmitter secretion synaptic vesicle postsynaptic density membrane cell junction synaptic vesicle membrane cytoplasmic vesicle synapse synaptic vesicle clustering extrinsic component of synaptic vesicle membrane glutamatergic synapse synaptic vesicle cycle uc007gnn.1 uc007gnn.2 uc007gnn.3 uc007gnn.4 
ENSMUST00000120639.9 Cracd ENSMUST00000120639.9 capping protein inhibiting regulator of actin, transcript variant 4 (from RefSeq NM_001408678.1) CRACD_MOUSE Cracd Crad E9Q3Y7 E9Q5L4 E9QLP4 ENSMUST00000120639.1 ENSMUST00000120639.2 ENSMUST00000120639.3 ENSMUST00000120639.4 ENSMUST00000120639.5 ENSMUST00000120639.6 ENSMUST00000120639.7 ENSMUST00000120639.8 Kiaa1211 NM_001408678 Q5PR69 Q80TH6 Q8C7K8 Q8C7R0 Q8C9F2 Q8CDM6 uc008xvf.1 uc008xvf.2 uc008xvf.3 uc008xvf.4 Involved in epithelial cell integrity by acting on the dynamics of the actin cytoskeleton (PubMed:30361697). Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin (By similarity). Directly interacts with actin-capping proteins CAPZA1, CAPZA2 and CAPZB; this interaction decreases the binding of capping proteins to actin. Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=3; IsoId=Q5PR69-3; Sequence=Displayed; Name=4; IsoId=Q5PR69-4; Sequence=VSP_061664; Expressed in the small intestine (at protein level). Knockout mice display adenoma development in the small intestine in an age-dependent manner. They also develop pulmonary lesions resembling early small cell lung cancer and solid- pseudopapillary neoplasm of the pancreas. Tumors from mutant animals show increased expression of Wnt/beta-catenin target genes without the alteration of other signaling pathways. Intestinal tumors exhibit disorganized and decreased levels of F-actin. molecular_function cellular_component cytoplasm cytosol epithelial structure maintenance maintenance of gastrointestinal epithelium positive regulation of actin filament polymerization negative regulation of barbed-end actin filament capping uc008xvf.1 uc008xvf.2 uc008xvf.3 uc008xvf.4 
ENSMUST00000120642.9 D930020B18Rik ENSMUST00000120642.9 RIKEN cDNA D930020B18 gene (from RefSeq NM_177335.4) D3Z3G0 D3Z3G0_MOUSE D930020B18Rik ENSMUST00000120642.1 ENSMUST00000120642.2 ENSMUST00000120642.3 ENSMUST00000120642.4 ENSMUST00000120642.5 ENSMUST00000120642.6 ENSMUST00000120642.7 ENSMUST00000120642.8 NM_177335 uc011xoz.1 uc011xoz.2 uc011xoz.3 uc011xoz.1 uc011xoz.2 uc011xoz.3 
ENSMUST00000120645.8 Gsto2 ENSMUST00000120645.8 glutathione S-transferase omega 2, transcript variant 2 (from RefSeq NM_030051.1) ENSMUST00000120645.1 ENSMUST00000120645.2 ENSMUST00000120645.3 ENSMUST00000120645.4 ENSMUST00000120645.5 ENSMUST00000120645.6 ENSMUST00000120645.7 GSTO2_MOUSE NM_030051 Q8K2Q2 uc008hvs.1 uc008hvs.2 uc008hvs.3 Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Reaction=2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate; Xref=Rhea:RHEA:24424, ChEBI:CHEBI:38290, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:58539; EC=1.8.5.1; Evidence=; Reaction=2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid; Xref=Rhea:RHEA:15969, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17826, ChEBI:CHEBI:33409, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.20.4.2; Evidence=; Belongs to the GST superfamily. Omega family. glutathione transferase activity cytoplasm xenobiotic metabolic process oxidoreductase activity transferase activity L-ascorbic acid metabolic process identical protein binding glutathione dehydrogenase (ascorbate) activity methylarsonate reductase activity oxidation-reduction process cellular response to arsenic-containing substance cellular oxidant detoxification uc008hvs.1 uc008hvs.2 uc008hvs.3 
ENSMUST00000120673.8 Adgrl3 ENSMUST00000120673.8 adhesion G protein-coupled receptor L3, transcript variant 10 (from RefSeq NM_001359831.1) Adgrl3 D3Z5M6 D3Z5M6_MOUSE ENSMUST00000120673.1 ENSMUST00000120673.2 ENSMUST00000120673.3 ENSMUST00000120673.4 ENSMUST00000120673.5 ENSMUST00000120673.6 ENSMUST00000120673.7 NM_001359831 uc290wqz.1 uc290wqz.2 Membrane ; Multi- pass membrane protein transmembrane signaling receptor activity G-protein coupled receptor activity signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway membrane integral component of membrane carbohydrate binding uc290wqz.1 uc290wqz.2 
ENSMUST00000120691.9 Rab11fip3 ENSMUST00000120691.9 RAB11 family interacting protein 3 (class II), transcript variant 2 (from RefSeq NM_001162868.2) ENSMUST00000120691.1 ENSMUST00000120691.2 ENSMUST00000120691.3 ENSMUST00000120691.4 ENSMUST00000120691.5 ENSMUST00000120691.6 ENSMUST00000120691.7 ENSMUST00000120691.8 Kiaa0665 NM_001162868 Q8CHD8 Q8JZT3 RFIP3_MOUSE Rab11fip3 uc008bde.1 uc008bde.2 uc008bde.3 uc008bde.4 uc008bde.5 Downstream effector molecule for Rab11 GTPase which acts as a regulator of endocytic trafficking and intracellular ciliogenesis by participating in membrane delivery (PubMed:18685082). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex. The functional Rab11-RAB11FIP3-dynein complex then regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle. Facilitates the interaction between dynein and dynactin and activates dynein processivity (By similarity). Binding with ASAP1 is also needed to regulates the pericentrosomal localization of recycling endosomes (PubMed:18685082). The Rab11-RAB11FIP3 complex is also implicated in the transport and fusion of vesicles derived from recycling endosomes to the cleavage furrow during late cytokinesis and abscission. Also regulates cleavage furrow ingression and abscission together with RACGAP1. Required for ARF6 recruitment to the cleavage furrow during cytokinesis. Involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation. Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin. Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway. May play a role in breast cancer cell motility by regulating actin cytoskeleton (By similarity). Homodimer. Interacts with RAB11A; the interaction is direct and is required for the recruitment to endosomes. Interacts with RAB11B. Forms a ternary complex with RAB11A and dynein intermediate chain DYNC1LI1; RAB11FIP3 links RAB11A to dynein and the interaction regulates endocytic trafficking. Interacts with dynein intermediate chain and dynactin (DCTN1); the interaction activates dynein processivity. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RACGAP1/MgcRacGAP; interaction takes place during late stage of cytokinesis and is required for recruitment to the midbody. Forms a complex with RAB11A and Rabin8/RAB3IP, probably a heterohexamer with two of each protein subunit, where RAB3IP and RAB11FIP3 simultaneously bind to RAB11A; the complex promotes preciliary trafficking (By similarity). Forms a complex containing RAB11A, ASAP1, RAB3IP, RAP11FIP3 and ARF4; the complex promotes preciliary trafficking; the complex binds to RHO in photoreceptor cells and promotes RHO ciliary transport (PubMed:18685082). Interacts with EXOC7. Interacts with RAB11FIP4. Interacts with RAB25 (By similarity). Recycling endosome membrane ; Peripheral membrane protein Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cleavage furrow Midbody Golgi apparatus membrane ; Peripheral membrane protein Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Note=In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission. Interaction with Rab11 mediates localization to endosomes. Interaction with ARF6 mediates localization to the midbody. Localized to the Golgi and TGN when interacting with RHO in photoreceptors. Localized to rhodopsin transport carriers when interacting with RAB11A and ASAP1 in photoreceptors. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CHD8-1; Sequence=Displayed; Name=2; IsoId=Q8CHD8-2; Sequence=VSP_038667; Name=3; IsoId=Q8CHD8-3; Sequence=VSP_038668; The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B). calcium ion binding protein binding nucleoplasm cytoplasm endosome centrosome microtubule organizing center cytoskeleton cell cycle membrane vesicle-mediated transport Rab GTPase binding endocytic vesicle ADP-ribosylation factor binding midbody cleavage furrow endocytic recycling regulation of cytokinesis protein homodimerization activity intracellular membrane-bounded organelle intercellular bridge metal ion binding cell division dynein light intermediate chain binding recycling endosome recycling endosome membrane protein localization to cilium negative regulation of adiponectin secretion uc008bde.1 uc008bde.2 uc008bde.3 uc008bde.4 uc008bde.5 
ENSMUST00000120697.8 Scamp3 ENSMUST00000120697.8 secretory carrier membrane protein 3, transcript variant 1 (from RefSeq NM_001309909.1) ENSMUST00000120697.1 ENSMUST00000120697.2 ENSMUST00000120697.3 ENSMUST00000120697.4 ENSMUST00000120697.5 ENSMUST00000120697.6 ENSMUST00000120697.7 NM_001309909 Q3UXS0 Q3UXS0_MOUSE Scamp3 uc008pxx.1 uc008pxx.2 uc008pxx.3 uc008pxx.4 Membrane ulti-pass membrane protein Belongs to the SCAMP family. protein transport membrane integral component of membrane ubiquitin protein ligase binding intracellular membrane-bounded organelle uc008pxx.1 uc008pxx.2 uc008pxx.3 uc008pxx.4 
ENSMUST00000120705.3 Tbc1d10b ENSMUST00000120705.3 TBC1 domain family, member 10b (from RefSeq NM_144522.5) ENSMUST00000120705.1 ENSMUST00000120705.2 NM_144522 Q6GQW9 Q6PIZ5 Q8BHL3 Q91XR3 TB10B_MOUSE uc009juo.1 uc009juo.2 uc009juo.3 uc009juo.4 Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A and RAB35. Does not act on RAB2A and RAB6A (By similarity). Cytoplasm Sequence=AAH25889.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH72576.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAK82984.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC33022.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC33025.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; GTPase activator activity cytoplasm cytosol plasma membrane intracellular protein transport Rab GTPase binding retrograde transport, endosome to Golgi regulation of GTPase activity activation of GTPase activity uc009juo.1 uc009juo.2 uc009juo.3 uc009juo.4 
ENSMUST00000120717.8 Capn11 ENSMUST00000120717.8 calpain 11 (from RefSeq NM_001013767.2) CAN11_MOUSE Capn11 ENSMUST00000120717.1 ENSMUST00000120717.2 ENSMUST00000120717.3 ENSMUST00000120717.4 ENSMUST00000120717.5 ENSMUST00000120717.6 ENSMUST00000120717.7 NM_001013767 Q6J756 uc008crh.1 uc008crh.2 uc008crh.3 Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Heterodimer of a large (catalytic) and a small (regulatory) subunit. Cytoplasmic vesicle, secretory vesicle, acrosome Expressed exclusively in testis, where it is restricted to spermatocytes and during the later stages of meiosis (at protein level). Belongs to the peptidase C2 family. acrosomal vesicle calcium-dependent cysteine-type endopeptidase activity calcium ion binding cytoplasm proteolysis hydrolase activity cytoplasmic vesicle metal ion binding uc008crh.1 uc008crh.2 uc008crh.3 
ENSMUST00000120722.2 Chmp1b2 ENSMUST00000120722.2 charged multivesicular body protein 1B2 (from RefSeq NM_025921.3) B1ATX3 CH1B2_MOUSE Chmp1b2 ENSMUST00000120722.1 NM_025921 Q9CQD4 uc009ucj.1 uc009ucj.2 uc009ucj.3 uc009ucj.4 Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells (By similarity). Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with CHMP1A. Interacts with VTA1; the interaction probably involves the open conformation of CHMP1B. Interacts with CHMP2A. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with SPAST (via MIT domain); the interaction is direct. Interacts with IST1. Interacts with MITD1. Interacts with STAMBP (By similarity). Cytoplasm, cytosol Endosome Late endosome membrane ; Peripheral membrane protein Note=Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body (By similarity). Belongs to the SNF7 family. ESCRT III complex molecular_function cytoplasm endosome multivesicular body cytosol vacuolar transport cell cycle protein transport membrane late endosome membrane endosome transport via multivesicular body sorting pathway late endosome to vacuole transport cell division uc009ucj.1 uc009ucj.2 uc009ucj.3 uc009ucj.4 
ENSMUST00000120734.2 Gm5934 ENSMUST00000120734.2 predicted gene 5934 (from RefSeq NM_001100444.2) D3Z4U6 D3Z4U6_MOUSE ENSMUST00000120734.1 Gm5934 NM_001100444 uc012hfj.1 uc012hfj.2 uc012hfj.3 uc012hfj.4 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc012hfj.1 uc012hfj.2 uc012hfj.3 uc012hfj.4 
ENSMUST00000120757.2 Slc5a4b ENSMUST00000120757.2 solute carrier family 5 (neutral amino acid transporters, system A), member 4b (from RefSeq NM_023219.2) ENSMUST00000120757.1 NM_023219 Q91ZP4 Q9ET36 S5A4B_MOUSE Slc5a4b uc007ftx.1 uc007ftx.2 uc007ftx.3 Low-affinity sodium/D-glucose symporter (Probable) (PubMed:22301059). Generates D-glucose-induced depolarization in a pH- independent manner (PubMed:22301059). Reaction=D-glucose(out) + 2 Na(+)(out) = D-glucose(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70495, ChEBI:CHEBI:4167, ChEBI:CHEBI:29101; Evidence=; Inhibited by phlorizin. Cell membrane ; Multi-pass membrane protein Expressed in small intestine (PubMed:22301059). Expressed in kidney (PubMed:12969150). Significantly increased by cadnium. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. Sequence=AAG01742.1; Type=Frameshift; Evidence=; cation:sugar symporter activity glucose:sodium symporter activity plasma membrane sodium ion transport carbohydrate transport membrane integral component of membrane transmembrane transporter activity transmembrane transport glucose transmembrane transport uc007ftx.1 uc007ftx.2 uc007ftx.3 
ENSMUST00000120796.8 Kcnt2 ENSMUST00000120796.8 potassium channel, subfamily T, member 2 (from RefSeq NM_001081027.3) D3Z649 D3Z649_MOUSE ENSMUST00000120796.1 ENSMUST00000120796.2 ENSMUST00000120796.3 ENSMUST00000120796.4 ENSMUST00000120796.5 ENSMUST00000120796.6 ENSMUST00000120796.7 Kcnt2 NM_001081027 uc011wth.1 uc011wth.2 uc011wth.3 Membrane ; Multi- pass membrane protein intracellular sodium activated potassium channel activity potassium channel activity plasma membrane potassium ion transport outward rectifier potassium channel activity membrane integral component of membrane chloride-activated potassium channel activity potassium ion export across plasma membrane uc011wth.1 uc011wth.2 uc011wth.3 
ENSMUST00000120834.8 Pld1 ENSMUST00000120834.8 phospholipase D1, transcript variant 6 (from RefSeq NM_001410532.1) ENSMUST00000120834.1 ENSMUST00000120834.2 ENSMUST00000120834.3 ENSMUST00000120834.4 ENSMUST00000120834.5 ENSMUST00000120834.6 ENSMUST00000120834.7 NM_001410532 Pld1 Q6NVF2 Q6NVF2_MOUSE uc008ott.1 uc008ott.2 uc008ott.3 uc008ott.4 Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl- sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=3.1.4.4; Evidence=; Belongs to the phospholipase D family. catalytic activity phospholipase D activity endosome Golgi apparatus phosphatidic acid biosynthetic process lipid catabolic process apical plasma membrane hydrolase activity endocytic vesicle regulation of microvillus assembly phosphatidylinositol binding inositol lipid-mediated signaling N-acylphosphatidylethanolamine-specific phospholipase D activity cholinergic synapse uc008ott.1 uc008ott.2 uc008ott.3 uc008ott.4 
ENSMUST00000120860.2 ENSMUSG00000121767 ENSMUST00000120860.2 ENSMUSG00000121767 (from geneSymbol) AK038173 ENSMUST00000120860.1 uc029utz.1 uc029utz.2 uc029utz.1 uc029utz.2 
ENSMUST00000120861.8 Zfp455 ENSMUST00000120861.8 zinc finger protein 455 (from RefSeq NM_001048204.1) ENSMUST00000120861.1 ENSMUST00000120861.2 ENSMUST00000120861.3 ENSMUST00000120861.4 ENSMUST00000120861.5 ENSMUST00000120861.6 ENSMUST00000120861.7 NM_001048204 Q7M6X9 Q7M6X9_MOUSE Zfp455 uc007rak.1 uc007rak.2 Nucleus nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007rak.1 uc007rak.2 
ENSMUST00000120866.8 Lrrc18 ENSMUST00000120866.8 leucine rich repeat containing 18, transcript variant 2 (from RefSeq NM_001146021.1) ENSMUST00000120866.1 ENSMUST00000120866.2 ENSMUST00000120866.3 ENSMUST00000120866.4 ENSMUST00000120866.5 ENSMUST00000120866.6 ENSMUST00000120866.7 LRC18_MOUSE Mtlr1 NM_001146021 Q6P8T8 Q80ZT3 Q9CQ07 Q9CW01 Q9DA89 uc011zir.1 uc011zir.2 uc011zir.3 May be involved in the regulation of spermatogenesis and sperm maturation. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQ07-1; Sequence=Displayed; Name=2; IsoId=Q9CQ07-2; Sequence=VSP_015741; Exclusively expressed in spermatocytes and roud spermatids within seminiferous tubules during spermatogenesis. Up-regulated during sexual maturation and dowm-regulated by experimental cryptorchidism and heat stress. Sequence=AAH48444.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; molecular_function cellular_component cytoplasm uc011zir.1 uc011zir.2 uc011zir.3 
ENSMUST00000120874.5 Defa33 ENSMUST00000120874.5 defensin, alpha, 33 (from RefSeq NM_001270555.1) Defa2 Defa33 Defcr20 E9Q4S6 E9Q5P7 ENSMUST00000120874.1 ENSMUST00000120874.2 ENSMUST00000120874.3 ENSMUST00000120874.4 NM_001270555 Q8C1N9 Q8C1N9_MOUSE uc029wrq.1 uc029wrq.2 uc029wrq.3 uc029wrq.4 Secreted Belongs to the alpha-defensin family. extracellular region extracellular space defense response defense response to bacterium uc029wrq.1 uc029wrq.2 uc029wrq.3 uc029wrq.4 
ENSMUST00000120875.8 Ankrd50 ENSMUST00000120875.8 ankyrin repeat domain 50, transcript variant 2 (from RefSeq NM_001167883.1) Ankrd50 D3Z643 D3Z643_MOUSE ENSMUST00000120875.1 ENSMUST00000120875.2 ENSMUST00000120875.3 ENSMUST00000120875.4 ENSMUST00000120875.5 ENSMUST00000120875.6 ENSMUST00000120875.7 NM_001167883 uc008pbd.1 uc008pbd.2 uc008pbd.3 uc008pbd.4 molecular_function uc008pbd.1 uc008pbd.2 uc008pbd.3 uc008pbd.4 
ENSMUST00000120876.2 Ric3 ENSMUST00000120876.2 RIC3 acetylcholine receptor chaperone, transcript variant 3 (from RefSeq NM_001311161.1) D3YTZ9 D3YTZ9_MOUSE ENSMUST00000120876.1 NM_001311161 Ric3 uc009jdh.1 uc009jdh.2 uc009jdh.3 uc009jdh.4 Belongs to the ric-3 family. membrane integral component of membrane uc009jdh.1 uc009jdh.2 uc009jdh.3 uc009jdh.4 
ENSMUST00000120879.8 Pgap2 ENSMUST00000120879.8 post-GPI attachment to proteins 2, transcript variant 62 (from RefSeq NM_001408170.1) ENSMUST00000120879.1 ENSMUST00000120879.2 ENSMUST00000120879.3 ENSMUST00000120879.4 ENSMUST00000120879.5 ENSMUST00000120879.6 ENSMUST00000120879.7 Frag1 NM_001408170 PGAP2_MOUSE Q3TQR0 Q3TVW2 Q3U814 Q3UJI0 Q99KA1 uc009ird.1 uc009ird.2 uc009ird.3 uc009ird.4 Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity). Interacts with PGAP2IP. Golgi apparatus membrane ; Multi- pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TQR0-1; Sequence=Displayed; Name=2; IsoId=Q3TQR0-2; Sequence=VSP_032553; Name=3; IsoId=Q3TQR0-3; Sequence=VSP_032552; Belongs to the PGAP2 family. Sequence=BAE37322.1; Type=Erroneous initiation; Evidence=; Golgi membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus GPI anchor biosynthetic process membrane integral component of membrane protein localization to plasma membrane uc009ird.1 uc009ird.2 uc009ird.3 uc009ird.4 
ENSMUST00000120900.8 Mmp27 ENSMUST00000120900.8 matrix metallopeptidase 27 (from RefSeq NM_001310717.1) D3Z6I1 D3Z6I1_MOUSE ENSMUST00000120900.1 ENSMUST00000120900.2 ENSMUST00000120900.3 ENSMUST00000120900.4 ENSMUST00000120900.5 ENSMUST00000120900.6 ENSMUST00000120900.7 Mmp27 NM_001310717 uc009oct.1 uc009oct.2 uc009oct.3 uc009oct.4 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Can bind about 5 Ca(2+) ions per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. Belongs to the peptidase M10A family. metalloendopeptidase activity proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix extrinsic component of endoplasmic reticulum membrane metal ion binding uc009oct.1 uc009oct.2 uc009oct.3 uc009oct.4 
ENSMUST00000120918.8 Lyzl4 ENSMUST00000120918.8 lysozyme-like 4, transcript variant 1 (from RefSeq NM_001357346.2) ENSMUST00000120918.1 ENSMUST00000120918.2 ENSMUST00000120918.3 ENSMUST00000120918.4 ENSMUST00000120918.5 ENSMUST00000120918.6 ENSMUST00000120918.7 LYZL4_MOUSE Lyc4 NM_001357346 Q9D925 uc292mif.1 uc292mif.2 May be involved in fertilization (PubMed:21444326). Has no detectable bacteriolytic in vitro (PubMed:21444326). Has no lysozyme activity in vitro (By similarity). Monomer. Secreted Cytoplasmic vesicle, secretory vesicle, acrosome Cell projection, cilium, flagellum Note=Found in the principal piece of sperm tail (PubMed:21444326). Expressed strongly in testis and in epididymis, and weakly in brain and lung (PubMed:21444326, PubMed:24013621). Detected in sperm (at protein level) (PubMed:21444326). No expression in the testis of 2-weeks-old neonates, the expression reaches a peak level at 12 weeks. After that, the level gradually decreases as the age increases (PubMed:21444326, PubMed:24013621). Belongs to the glycosyl hydrolase 22 family. Although it belongs to the glycosyl hydrolase 22 family, Gly- 72 is present instead of the conserved Asp which is an active site residue. It is therefore expected that this protein lacks hydrolase activity. Sequence=BAB25023.2; Type=Erroneous initiation; Evidence=; acrosomal vesicle lysozyme activity extracellular region extracellular space cilium single fertilization fertilization cytoplasmic vesicle motile cilium sperm flagellum cell projection defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to bacterium uc292mif.1 uc292mif.2 
ENSMUST00000120927.8 Acot3 ENSMUST00000120927.8 acyl-CoA thioesterase 3, transcript variant 2 (from RefSeq NM_001346701.1) ACOT3_MOUSE ENSMUST00000120927.1 ENSMUST00000120927.2 ENSMUST00000120927.3 ENSMUST00000120927.4 ENSMUST00000120927.5 ENSMUST00000120927.6 ENSMUST00000120927.7 NM_001346701 Pte1a Pte2 Pte2a Q6Q2Z7 Q9QYR7 uc007oeg.1 uc007oeg.2 uc007oeg.3 uc007oeg.4 Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:15007068, PubMed:16940157). Mainly active on long-chain acyl-CoAs (PubMed:15007068, PubMed:16940157). May have a function in termination of beta-oxidation of fatty acids (PubMed:16940157). Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence=; Reaction=decanoyl-CoA + H2O = CoA + decanoate + H(+); Xref=Rhea:RHEA:40059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40060; Evidence=; Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence=; Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=; Reaction=H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate; Xref=Rhea:RHEA:30139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30140; Evidence=; Reaction=eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+); Xref=Rhea:RHEA:40147, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32360, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40148; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40140; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+); Xref=Rhea:RHEA:40143, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40144; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)- eicosatetraenoate + CoA + H(+); Xref=Rhea:RHEA:40151, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40152; Evidence=; Reaction=H2O + tetracosanoyl-CoA = CoA + H(+) + tetracosanoate; Xref=Rhea:RHEA:40787, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:31014, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40788; Evidence=; Reaction=H2O + hexacosanoyl-CoA = CoA + H(+) + hexacosanoate; Xref=Rhea:RHEA:40791, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:31013, ChEBI:CHEBI:57287, ChEBI:CHEBI:64868; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40792; Evidence=; Reaction=docosanoyl-CoA + H2O = CoA + docosanoate + H(+); Xref=Rhea:RHEA:40783, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:23858, ChEBI:CHEBI:57287, ChEBI:CHEBI:65059; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40784; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+); Xref=Rhea:RHEA:40131, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40132; Evidence=; Kinetic parameters: KM=10.9 uM for hexanoyl-coA ; KM=46.2 uM for octanoyl-coA ; KM=7.7 uM for decanoyl-coA ; KM=7.6 uM for dodecanoyl-coA ; KM=3.8 uM for tetradecanoyl-coA ; KM=4.0 uM for hexadecanoyl-coA ; KM=2.8 uM for (9Z)-hexadecenoyl-coA ; KM=4.2 uM for octadecanoyl-coA ; KM=4.6 uM for (9Z)-octadecenoyl-coA ; KM=2.6 uM for (9Z,12Z)-octadecadienoyl-coA ; KM=2.2 uM for eicosanoyl-coA ; KM=7.2 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoyl-coA ; KM=2.3 uM for docosanoyl-coA ; KM=6.3 uM for tetracosanoyl-coA ; KM=4.5 uM for hexacosanoyl-coA ; Vmax=0.02 umol/min/mg enzyme with hexanoyl-coA as substrate ; Vmax=0.23 umol/min/mg enzyme with octanoyl-coA as substrate ; Vmax=0.87 umol/min/mg enzyme with decanoyl-coA as substrate ; Vmax=1.40 umol/min/mg enzyme with dodecanoyl-coA as substrate ; Vmax=1.60 umol/min/mg enzyme with tetradecanoyl-coA as substrate ; Vmax=1.85 umol/min/mg enzyme with hexadecanoyl-coA as substrate ; Vmax=0.93 umol/min/mg enzyme with (9Z)-hexadecenoyl-coA as substrate ; Vmax=1.43 umol/min/mg enzyme with octadecanoyl-coA as substrate ; Vmax=0.85 umol/min/mg enzyme with (9Z)-octadecenoyl-coA as substrate ; Vmax=0.63 umol/min/mg enzyme with (9Z,12Z)-octadecadienoyl-coA as substrate ; Vmax=0.71 umol/min/mg enzyme with eicosanoyl-coA as substrate ; Vmax=0.70 umol/min/mg enzyme with (5Z,8Z,11Z,14Z)-eicosatetraenoyl- coA as substrate ; Vmax=0.37 umol/min/mg enzyme with docosanoyl-coA as substrate ; Vmax=0.20 umol/min/mg enzyme with tetracosanoyl-coA as substrate ; Vmax=0.22 umol/min/mg enzyme with hexacosanoyl-coA as substrate ; Lipid metabolism; fatty acid metabolism. Peroxisome Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PTE-Ia 5':1; IsoId=Q9QYR7-1; Sequence=Displayed; Name=2; Synonyms=PTE-Ia 5':2; IsoId=Q9QYR7-2; Sequence=VSP_010994; Widely expressed. Highly expressed in the kidney, expressed at low level in the liver. Isoform 2 is expressed in the kidney, but not in the liver. Isoform 1 is liver-specific (PubMed:10567408). Highly expressed in kidney (at protein level) (PubMed:15007068). In the liver and kidney, by peroxisome proliferator (such as Clofibrate) treatment, via the peroxisome proliferator-activated receptors (PPARs) or fasting for 24 hours. Belongs to the C/M/P thioester hydrolase family. very long-chain fatty acid metabolic process long-chain fatty acid metabolic process peroxisome cytosol lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process palmitoyl-CoA hydrolase activity hydrolase activity thiolester hydrolase activity saturated monocarboxylic acid metabolic process unsaturated monocarboxylic acid metabolic process acyl-CoA hydrolase activity carboxylic ester hydrolase activity uc007oeg.1 uc007oeg.2 uc007oeg.3 uc007oeg.4 
ENSMUST00000120929.9 Tsks ENSMUST00000120929.9 testis-specific serine kinase substrate, transcript variant 1 (from RefSeq NM_011651.2) E9QJS9 ENSMUST00000120929.1 ENSMUST00000120929.2 ENSMUST00000120929.3 ENSMUST00000120929.4 ENSMUST00000120929.5 ENSMUST00000120929.6 ENSMUST00000120929.7 ENSMUST00000120929.8 NM_011651 O54887 Stk22s1 TSKS_MOUSE uc009gry.1 uc009gry.2 uc009gry.3 uc009gry.4 uc009gry.5 This gene is a member of a small family of testis-specific serine/threonine kinases. This gene may play a role in testicular physiology or spermiogenesis. Its expression is restricted to the testis during the last stages of spermatid maturation. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]. May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Concentrates in spermatid centrioles during flagellogenesis. Associates with acrosomal vesicle in sperm. In elongating spermatids, accumulates in a ring-shaped structure originating from the chromatoid body. Testis specific. Phosphorylated on serine residue(s) by STK22A/TSSK1 and STK22B/TSSK2. Sequence=AAC03366.2; Type=Frameshift; Evidence=; acrosomal vesicle cytoplasm centriole cytoskeleton negative regulation of phosphatase activity protein kinase binding cytoplasmic vesicle uc009gry.1 uc009gry.2 uc009gry.3 uc009gry.4 uc009gry.5 
ENSMUST00000120933.5 Kbtbd12 ENSMUST00000120933.5 kelch repeat and BTB (POZ) domain containing 12 (from RefSeq NM_001278671.2) E9QJU5 ENSMUST00000120933.1 ENSMUST00000120933.2 ENSMUST00000120933.3 ENSMUST00000120933.4 KBTBC_MOUSE Klhdc6 NM_001278671 Q9D618 uc033iti.1 uc033iti.2 uc033iti.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D618-1; Sequence=Displayed; Name=2; IsoId=Q9D618-2; Sequence=VSP_032356, VSP_032357; [Isoform 2]: Due to intron retention. uc033iti.1 uc033iti.2 uc033iti.3 
ENSMUST00000120963.8 Aasdh ENSMUST00000120963.8 aminoadipate-semialdehyde dehydrogenase, transcript variant 1 (from RefSeq NM_173765.4) ACSF4_MOUSE Acsf4 ENSMUST00000120963.1 ENSMUST00000120963.2 ENSMUST00000120963.3 ENSMUST00000120963.4 ENSMUST00000120963.5 ENSMUST00000120963.6 ENSMUST00000120963.7 NM_173765 Q3V3L2 Q505K4 Q80WC9 Q8BRP4 U26 uc008xvi.1 uc008xvi.2 uc008xvi.3 The gene product is a cytosolic enzyme involved in the production of alpha-aminoadipic acid from alpha-aminoadipic semialdehyde. It is postulated that this enzyme plays a role in lysine metabolism. There is currently debate regarding this enzyme's putative requirement of pyrroloquinoline quinine as an essential cofactor. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Jan 2010]. Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an as yet unknown acceptor via an amide bond. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80WC9-1; Sequence=Displayed; Name=2; IsoId=Q80WC9-2; Sequence=VSP_030715; Name=3; IsoId=Q80WC9-3; Sequence=VSP_030714; Has been shown to be up-regulated by a lysine-rich diet (PubMed:12712191). However, levels of expression have also been shown not to be significantly changed even when diets differ markedly in PQQ and lysine content (PubMed:17029795). Belongs to the ATP-dependent AMP-binding enzyme family. Was suggested to bind pyrroloquinoline quinone (PQQ) based on prediction tools and indirect results (PubMed:12712191). However, this has not been confirmed in other publications (PubMed:15689995, PubMed:15689994). In invertebrates, the aminoadipate-semialdehyde dehydrogenase reaction is a key step of the L-lysine biosynthesis pathway which is not fully conserved in vertebrates and it has been suggested that this protein participates in the reverse reaction i.e. in lysine catabolism (PubMed:12712191). However, this is unlikely to be the case as no dehydrogenase activity has been detected and the authentic mammalian 2- aminoadipate semialdehyde dehydrogenase has been identified as ALDH7A1 (PubMed:24467666). nucleotide binding molecular_function catalytic activity ATP binding cellular_component lipid metabolic process fatty acid metabolic process ligase activity acid-thiol ligase activity beta-alanine metabolic process amino acid activation for nonribosomal peptide biosynthetic process uc008xvi.1 uc008xvi.2 uc008xvi.3 
ENSMUST00000120990.2 Olfml1 ENSMUST00000120990.2 olfactomedin-like 1 (from RefSeq NM_172907.3) BC047207 ENSMUST00000120990.1 NM_172907 Olfml1 Q8BSH2 Q8BSH2_MOUSE uc009jbb.1 uc009jbb.2 uc009jbb.3 uc009jbb.4 Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function cellular_component biological_process uc009jbb.1 uc009jbb.2 uc009jbb.3 uc009jbb.4 
ENSMUST00000121010.9 Jakmip1 ENSMUST00000121010.9 janus kinase and microtubule interacting protein 1, transcript variant 5 (from RefSeq NM_001401055.1) D3Z4U5 D3Z4U5_MOUSE ENSMUST00000121010.1 ENSMUST00000121010.2 ENSMUST00000121010.3 ENSMUST00000121010.4 ENSMUST00000121010.5 ENSMUST00000121010.6 ENSMUST00000121010.7 ENSMUST00000121010.8 Jakmip1 NM_001401055 uc290uxt.1 uc290uxt.2 Belongs to the JAKMIP family. microtubule binding kinase binding uc290uxt.1 uc290uxt.2 
ENSMUST00000121017.5 Kash5 ENSMUST00000121017.5 KASH domain containing 5 (from RefSeq NM_201374.2) Ccdc155 E9QNS3 E9QQ69 ENSMUST00000121017.1 ENSMUST00000121017.2 ENSMUST00000121017.3 ENSMUST00000121017.4 KASH5_MOUSE Kash5 NM_201374 Q80VJ8 uc009gub.1 uc009gub.2 uc009gub.3 As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation. Core component the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain- containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents is giving rise to specific assemblies. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain-containing protein. Interacts (via the last 22 AA) with SUN1; this interaction mediates its telomere localization by forming a SUN1:KASH5 LINC complex. Component of a probable SUN2:KASH5 LINC complex. Self-associates. Interacts with DYNC1H1, DCTN1, DYNC1I1/2 and PAFAH1B1; suggesting the association with the dynein-dynactin motor complex. Q80VJ8; Q9D666: Sun1; NbExp=4; IntAct=EBI-11666341, EBI-6752574; Nucleus outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side Nucleus Chromosome, telomere Note=Localized exclusively at telomeres from the leptotene to diplotene stages. Colocalizes with SUN2 at sites of telomere attachment in meiocytes. At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles. Restricted to the testis and the early ootidogenesis ovary. Expressed in spermatocytes and oocytes (at protein level). The C-terminal 22 AA is required and sufficient for localization to telomeres at the nuclear envelope. Sequence=AAH50196.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; double-strand break repair via homologous recombination chromosome, telomeric region lateral element protein binding nucleus nuclear outer membrane chromosome actin filament organization synapsis spermatogenesis membrane integral component of membrane telomere localization LINC complex identical protein binding oogenesis spindle assembly meiotic cell cycle spindle localization dynein complex binding microtubule cytoskeleton organization involved in homologous chromosome segregation chromosome localization to nuclear envelope involved in homologous chromosome segregation meiotic spindle pole uc009gub.1 uc009gub.2 uc009gub.3 
ENSMUST00000121024.8 Eddm13 ENSMUST00000121024.8 epididymal protein 13, transcript variant 2 (from RefSeq NM_001177417.1) E9Q7F5 EDD13_MOUSE ENSMUST00000121024.1 ENSMUST00000121024.2 ENSMUST00000121024.3 ENSMUST00000121024.4 ENSMUST00000121024.5 ENSMUST00000121024.6 ENSMUST00000121024.7 Eddm13 Epp13 Gm6792 NM_001177417 uc033iwm.1 uc033iwm.2 uc033iwm.3 Secreted Highly expressed in segments II-V of the caput epididymis. molecular_function cellular_component extracellular region biological_process uc033iwm.1 uc033iwm.2 uc033iwm.3 
ENSMUST00000121040.8 Il24 ENSMUST00000121040.8 interleukin 24 (from RefSeq NM_053095.3) A0A087WQD7 A0A0R4J1N5 A0A0R4J1N5_MOUSE ENSMUST00000121040.1 ENSMUST00000121040.2 ENSMUST00000121040.3 ENSMUST00000121040.4 ENSMUST00000121040.5 ENSMUST00000121040.6 ENSMUST00000121040.7 Il24 NM_053095 uc007cmq.1 uc007cmq.2 uc007cmq.3 uc007cmq.4 Immune regulatory cytokine. Secreted Belongs to the IL-10 family. uc007cmq.1 uc007cmq.2 uc007cmq.3 uc007cmq.4 
ENSMUST00000121043.2 Hoxa10 ENSMUST00000121043.2 homeobox A10, transcript variant 4 (from RefSeq NM_001419405.1) ENSMUST00000121043.1 HXA10_MOUSE Hox-1.8 Hoxa-10 NM_001419405 P31310 Q80Y22 uc012ema.1 uc012ema.2 uc012ema.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. Interacts with SIRT2; the interaction is direct. Nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=a10-1; IsoId=P31310-1; Sequence=Displayed; Name=2; Synonyms=a10-2; IsoId=P31310-2; Sequence=VSP_002386, VSP_002387; Expressed in the developing limb bud where it is restricted to the mesenchyme along the proximal-distal axis. Also found in developing gut and urogenital tract. In adult tissue, both forms found in kidney but only isoform 1 is expressed in skeletal muscle. Embryonic expression increases from day 9 to day 12 and then declines to day 15. Belongs to the Abd-B homeobox family. Sequence=AAA67125.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH50839.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding skeletal system development DNA binding nucleus transcription factor complex cytoplasm regulation of transcription, DNA-templated multicellular organism development spermatogenesis single fertilization male gonad development anterior/posterior pattern specification proximal/distal pattern formation regulation of gene expression embryonic limb morphogenesis histone deacetylase binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uterus development uc012ema.1 uc012ema.2 uc012ema.3 
ENSMUST00000121044.6 Btc ENSMUST00000121044.6 betacellulin, epidermal growth factor family member (from RefSeq NM_007568.5) Btc ENSMUST00000121044.1 ENSMUST00000121044.2 ENSMUST00000121044.3 ENSMUST00000121044.4 ENSMUST00000121044.5 NM_007568 Q543J8 Q543J8_MOUSE uc008ybv.1 uc008ybv.2 uc008ybv.3 This gene encodes a member of the epidermal growth factor (EGF) family. These growth factors are ligands for the EGFR/ErbB receptor tyrosine kinases, and play roles in cell growth and differentiation. The encoded protein is synthesized as a transmembrane precursor that is proteolytically cleaved to generate a mature peptide, and plays a role in the differentiation of pancreatic beta cells. This gene may also play a protective role in acute pancreatitis, whereas increased expression of this gene may contribute to diabetic macular edema. Gene therapy using combinations of this gene and other pancreas-specific transcription factors may induce islet neogenesis and remediate hyperglycemia in type 1 diabetes. [provided by RefSeq, Apr 2011]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK076272.1, AK050206.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Lacks conserved residue(s) required for the propagation of feature annotation. epidermal growth factor receptor binding epidermal growth factor receptor signaling pathway growth factor activity membrane integral component of membrane positive regulation of urine volume positive regulation of cell differentiation positive regulation of mitotic nuclear division positive regulation of fibroblast proliferation uc008ybv.1 uc008ybv.2 uc008ybv.3 
ENSMUST00000121065.3 Or1p1b ENSMUST00000121065.3 Or1p1b (from geneSymbol) ENSMUST00000121065.1 ENSMUST00000121065.2 uc288abm.1 uc288abm.2 uc288abm.1 uc288abm.2 
ENSMUST00000121093.8 Rtkn ENSMUST00000121093.8 rhotekin, transcript variant 2 (from RefSeq NM_009106.3) E9QM24 ENSMUST00000121093.1 ENSMUST00000121093.2 ENSMUST00000121093.3 ENSMUST00000121093.4 ENSMUST00000121093.5 ENSMUST00000121093.6 ENSMUST00000121093.7 NM_009106 Q61192 Q8C6B2 Q8VIG7 RTKN_MOUSE Rtkn uc009cmt.1 uc009cmt.2 uc009cmt.3 uc009cmt.4 Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures (By similarity). Interacts via its C-terminal region with the TAX1BP3 PDZ domain. This interaction facilitates Rho-mediated activation of the c- Fos serum response element (SRE). Interacts with SEPT9 (By similarity). Specifically binds to GTP-bound RHOA, RHOB and RHOC and inhibits their GTPase activity. Q8C6B2; Q9QUI0: Rhoa; NbExp=3; IntAct=EBI-1162441, EBI-643583; Q8C6B2; P61586: RHOA; Xeno; NbExp=4; IntAct=EBI-1162441, EBI-446668; Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8C6B2-1; Sequence=Displayed; Name=2 ; IsoId=Q8C6B2-2; Sequence=VSP_052006; Abundantly expressed in brain and kidney. Weakly expressed in lung, testis, skeletal muscle, heart and thymus. nucleotide binding mitotic cytokinesis actomyosin contractile ring assembly GTPase inhibitor activity protein binding GTP binding actomyosin contractile ring cytosol apoptotic process signal transduction Rho protein signal transduction Rho GTPase binding GTP-Rho binding cortical cytoskeleton organization septin ring organization septin cytoskeleton organization negative regulation of GTPase activity regulation of apoptotic process protein localization to actomyosin contractile ring involved in mitotic cytokinesis uc009cmt.1 uc009cmt.2 uc009cmt.3 uc009cmt.4 
ENSMUST00000121096.8 Art3 ENSMUST00000121096.8 ADP-ribosyltransferase 3, transcript variant 1 (from RefSeq NM_001310664.1) Art3 E9QNU1 E9QNU1_MOUSE ENSMUST00000121096.1 ENSMUST00000121096.2 ENSMUST00000121096.3 ENSMUST00000121096.4 ENSMUST00000121096.5 ENSMUST00000121096.6 ENSMUST00000121096.7 NM_001310664 uc057bup.1 uc057bup.2 uc057bup.3 uc057bup.4 Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D- ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=2.4.2.31; Evidence= Belongs to the Arg-specific ADP-ribosyltransferase family. NAD(P)+-protein-arginine ADP-ribosyltransferase activity protein ADP-ribosylation transferase activity transferase activity, transferring glycosyl groups uc057bup.1 uc057bup.2 uc057bup.3 uc057bup.4 
ENSMUST00000121109.3 Pramel15 ENSMUST00000121109.3 PRAME like 15 (from RefSeq NM_001115077.1) B1ARV6 B1ARV6_MOUSE ENSMUST00000121109.1 ENSMUST00000121109.2 NM_001115077 Pramel15 uc012dos.1 uc012dos.2 uc012dos.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc012dos.1 uc012dos.2 uc012dos.3 
ENSMUST00000121110.8 Chchd7 ENSMUST00000121110.8 Monomer. (from UniProt Q8K2Q5) AK003308 CHCH7_MOUSE ENSMUST00000121110.1 ENSMUST00000121110.2 ENSMUST00000121110.3 ENSMUST00000121110.4 ENSMUST00000121110.5 ENSMUST00000121110.6 ENSMUST00000121110.7 Q3TGP4 Q8K2Q5 uc290kzh.1 uc290kzh.2 Monomer. Mitochondrion intermembrane space Belongs to the CHCHD7 family. molecular_function mitochondrion mitochondrial intermembrane space biological_process uc290kzh.1 uc290kzh.2 
ENSMUST00000121111.9 P3h1 ENSMUST00000121111.9 prolyl 3-hydroxylase 1, transcript variant 5 (from RefSeq NR_149723.1) A2A7Q4 A6PW85 ENSMUST00000121111.1 ENSMUST00000121111.2 ENSMUST00000121111.3 ENSMUST00000121111.4 ENSMUST00000121111.5 ENSMUST00000121111.6 ENSMUST00000121111.7 ENSMUST00000121111.8 Gros1 Lepre1 NR_149723 P3H1_MOUSE P3h1 Q3TWX8 Q3V1T4 Q8BSV2 Q8CFL3 Q9CWK5 Q9QZT6 Q9QZT7 uc008ulq.1 uc008ulq.2 uc008ulq.3 Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity). Reaction=2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]; Xref=Rhea:RHEA:22872, Rhea:RHEA- COMP:11676, Rhea:RHEA-COMP:11678, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50342, ChEBI:CHEBI:85428; EC=1.14.11.7; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Endoplasmic reticulum creted, extracellular space, extracellular matrix Note=Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan (CSPG). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=GROS1-L; IsoId=Q3V1T4-1; Sequence=Displayed; Name=2; Synonyms=GROS1-S; IsoId=Q3V1T4-2; Sequence=VSP_019350, VSP_019351; Name=3; IsoId=Q3V1T4-3; Sequence=VSP_019349; O-glycosylated; chondroitin sulfate. Belongs to the leprecan family. Sequence=BAB27041.1; Type=Frameshift; Evidence=; Sequence=BAE21065.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; iron ion binding extracellular region basement membrane nucleus cytoplasm endoplasmic reticulum plasma membrane protein folding positive regulation of neuron projection development oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen protein hydroxylation peptidyl-proline hydroxylation procollagen-proline 3-dioxygenase activity collagen fibril organization regulation of ossification negative regulation of cell growth L-ascorbic acid binding collagen metabolic process metal ion binding regulation of protein secretion protein stabilization dioxygenase activity oxidation-reduction process bone development negative regulation of post-translational protein modification uc008ulq.1 uc008ulq.2 uc008ulq.3 
ENSMUST00000121114.8 Slc43a1 ENSMUST00000121114.8 Uniport that mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine (PubMed:17322374). The transport activity is sodium ions-independent, electroneutral and mediated by a facilitated diffusion (PubMed:17322374). (from UniProt Q8BSM7) A2ATS3 AK046758 ENSMUST00000121114.1 ENSMUST00000121114.2 ENSMUST00000121114.3 ENSMUST00000121114.4 ENSMUST00000121114.5 ENSMUST00000121114.6 ENSMUST00000121114.7 LAT3_MOUSE Lat3 Q8BSM7 Q9D0H7 Slc43a1 uc289xmt.1 uc289xmt.2 Uniport that mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine (PubMed:17322374). The transport activity is sodium ions-independent, electroneutral and mediated by a facilitated diffusion (PubMed:17322374). Reaction=D-leucine(in) = D-leucine(out); Xref=Rhea:RHEA:73015, ChEBI:CHEBI:143079; Evidence=; Reaction=L-leucine(in) = L-leucine(out); Xref=Rhea:RHEA:73011, ChEBI:CHEBI:57427; Evidence=; Reaction=L-isoleucine(in) = L-isoleucine(out); Xref=Rhea:RHEA:70943, ChEBI:CHEBI:58045; Evidence=; Reaction=L-methionine(in) = L-methionine(out); Xref=Rhea:RHEA:70939, ChEBI:CHEBI:57844; Evidence=; Reaction=L-phenylalanine(in) = L-phenylalanine(out); Xref=Rhea:RHEA:27950, ChEBI:CHEBI:58095; Evidence=; Reaction=L-valine(in) = L-valine(out); Xref=Rhea:RHEA:29703, ChEBI:CHEBI:57762; Evidence=; Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Located in the apical plasma membrane of the podocyte foot processes (By similarity). Located in the plasma membrane of liver and skeletal muscle, and in the endoplasmic reticulum and in crystalline inclusions in pancreatic acinar cells (PubMed:17322374). Expressed in the kidney cortex as well as liver, pancreas, and skeletal muscle (PubMed:19443642). In kidney expressed in the glomerular tuft (at protein level) (PubMed:19443642). Expressed in liver, skeletal muscle and pancreas (at protein level) (PubMed:17322374). By nutrient starvation. Belongs to the SLC43A transporter (TC 2.A.1.44) family. Sequence=BAB27605.1; Type=Frameshift; Evidence=; Sequence=BAC27305.1; Type=Frameshift; Evidence=; integral component of plasma membrane amino acid transport neutral amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity neutral amino acid transport L-amino acid transport membrane integral component of membrane transmembrane transport L-alpha-amino acid transmembrane transport uc289xmt.1 uc289xmt.2 
ENSMUST00000121137.9 Rhpn1 ENSMUST00000121137.9 rhophilin, Rho GTPase binding protein 1, transcript variant 3 (from RefSeq NM_001411251.1) E9Q7Q7 E9Q7Q7_MOUSE ENSMUST00000121137.1 ENSMUST00000121137.2 ENSMUST00000121137.3 ENSMUST00000121137.4 ENSMUST00000121137.5 ENSMUST00000121137.6 ENSMUST00000121137.7 ENSMUST00000121137.8 NM_001411251 Rhpn1 uc007whd.1 uc007whd.2 uc007whd.3 uc007whd.4 Belongs to the RHPN family. signal transduction uc007whd.1 uc007whd.2 uc007whd.3 uc007whd.4 
ENSMUST00000121146.10 Tdrd5 ENSMUST00000121146.10 tudor domain containing 5, transcript variant 1 (from RefSeq NM_001134741.1) A7YQ76 D3YXM4 ENSMUST00000121146.1 ENSMUST00000121146.2 ENSMUST00000121146.3 ENSMUST00000121146.4 ENSMUST00000121146.5 ENSMUST00000121146.6 ENSMUST00000121146.7 ENSMUST00000121146.8 ENSMUST00000121146.9 Gm103 NM_001134741 Q5VCS6 TDRD5_MOUSE uc029qui.1 uc029qui.2 uc029qui.3 Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly. Cytoplasm Note=Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5VCS6-1; Sequence=Displayed; Name=2; IsoId=Q5VCS6-2; Sequence=VSP_041054; Gonad-specific. Mainly expressed in testis. Present at low level in ovary (at protein level). Specifically expressed in germ cells of the developing testis, starting from 12.5 dpc. The protein is detected as early as 13.5 dpc in embryonic testes, but expression declines around the perinatal period and then is restored at around 2 weeks after birth. Also detected in the embryonic ovary at a low level. In adult testis, mainly present in the spermatocytes from the pachytene stage onward (at protein level). Male sterility because of spermiogenic arrest at the round spermatid stage, with occasional failure in meiotic prophase. Effects are due to demethylation and subsequent derepression of transposable elements: germ cells fail to repress LINE-1 (L1) retrotransposons with DNA-demethylated promoters. Defects in chromatoid body (CB) and pi-body assembly are also observed. Interestingly, Tdrd5- deficient round spermatids injected into oocytes contribute to fertile offspring, showing that acquisition of a functional haploid genome may be uncoupled from Tdrd5 function. Belongs to the TDRD5 family. molecular_function cytoplasm multicellular organism development germ cell development spermatogenesis spermatid development cell differentiation P granule organization chromatoid body DNA methylation involved in gamete generation pi-body uc029qui.1 uc029qui.2 uc029qui.3 
ENSMUST00000121153.8 Rlim ENSMUST00000121153.8 ring finger protein, LIM domain interacting, transcript variant 1 (from RefSeq NM_011276.5) ENSMUST00000121153.1 ENSMUST00000121153.2 ENSMUST00000121153.3 ENSMUST00000121153.4 ENSMUST00000121153.5 ENSMUST00000121153.6 ENSMUST00000121153.7 NM_011276 Q8CE02 Q91X19 Q9CYY2 Q9WTV7 RNF12_MOUSE Rnf12 uc009uaa.1 uc009uaa.2 uc009uaa.3 E3 ubiquitin-protein ligase that acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts (via N-terminus) with TERF1. Interacts (via C- terminus) with ESR1 (By similarity). Interacts with LIM/homeobox factors such as LHX3. Interacts with LDB1, LDB2 and SIN3A. Interacts with LIMK1. Q9WTV7; O55203: Ldb2; NbExp=2; IntAct=EBI-15657872, EBI-15657830; Q9WTV7; P22227: Zfp42; NbExp=8; IntAct=EBI-15657872, EBI-2313372; Nucleus Ubiquitously expressed in early development. Expressed in the time window of embryonic stem (ES) cell differentiation. Expressed at higher level in female compared to males cells (at protein level). Belongs to the RNF12 family. negative regulation of transcription from RNA polymerase II promoter ubiquitin-protein transferase activity protein binding nucleus nucleoplasm cytosol ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity negative regulation of sequence-specific DNA binding transcription factor activity metal ion binding random inactivation of X chromosome ubiquitin protein ligase activity regulation of dosage compensation by inactivation of X chromosome uc009uaa.1 uc009uaa.2 uc009uaa.3 
ENSMUST00000121186.4 Or12e14 ENSMUST00000121186.4 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1STL1) A0A1L1STL1 A0A1L1STL1_MOUSE ENSMUST00000121186.1 ENSMUST00000121186.2 ENSMUST00000121186.3 Olfr1150 Or12e14 uc289xwt.1 uc289xwt.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xwt.1 uc289xwt.2 
ENSMUST00000121197.8 Dmrtc1a ENSMUST00000121197.8 DMRT-like family C1a, transcript variant 3 (from RefSeq NM_001038616.2) B1AX31 B1AX32 DMRTC_MOUSE Dmrt8.1 Dmrtc1 ENSMUST00000121197.1 ENSMUST00000121197.2 ENSMUST00000121197.3 ENSMUST00000121197.4 ENSMUST00000121197.5 ENSMUST00000121197.6 ENSMUST00000121197.7 NM_001038616 Q2PMY0 Q9D5U3 Q9D9R7 uc009tze.1 uc009tze.2 uc009tze.3 uc009tze.4 Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=isoform c; IsoId=Q9D9R7-1; Sequence=Displayed; Name=2; Synonyms=isoform b; IsoId=Q9D9R7-2; Sequence=VSP_019523, VSP_019524; Name=3; Synonyms=isoform a; IsoId=Q9D9R7-3; Sequence=VSP_019522, VSP_019523, VSP_019524; Expressed in Sertoli cells in male testis. Detected in many tissues at 13.5 dpc. Belongs to the DMRT family. Although related to other DMRT proteins, it does not contain a canonical DM DNA-binding domain. transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated protein homodimerization activity uc009tze.1 uc009tze.2 uc009tze.3 uc009tze.4 
ENSMUST00000121205.8 Matk ENSMUST00000121205.8 megakaryocyte-associated tyrosine kinase, transcript variant 2 (from RefSeq NM_001285853.1) D3Z4T5 D3Z4T5_MOUSE ENSMUST00000121205.1 ENSMUST00000121205.2 ENSMUST00000121205.3 ENSMUST00000121205.4 ENSMUST00000121205.5 ENSMUST00000121205.6 ENSMUST00000121205.7 Matk NM_001285853 uc007ggw.1 uc007ggw.2 uc007ggw.3 uc007ggw.4 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Belongs to the protein kinase superfamily. Tyr protein kinase family. nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity ATP binding protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation uc007ggw.1 uc007ggw.2 uc007ggw.3 uc007ggw.4 
ENSMUST00000121226.8 Abca17 ENSMUST00000121226.8 ATP-binding cassette, sub-family A member 17 (from RefSeq NM_001031621.3) ABCAH_MOUSE Abca17 E9PX95 ENSMUST00000121226.1 ENSMUST00000121226.2 ENSMUST00000121226.3 ENSMUST00000121226.4 ENSMUST00000121226.5 ENSMUST00000121226.6 ENSMUST00000121226.7 NM_001031621 Q4H4D7 uc008avk.1 uc008avk.2 uc008avk.3 Promotes cholesterol efflux from sperm which renders sperm capable of fertilization (PubMed:22237709). Has also been shown to decrease levels of intracellular esterified neutral lipids including cholesteryl esters, fatty acid esters and triacylglycerols (PubMed:15810880). Reaction=ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate; Xref=Rhea:RHEA:39051, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39052; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Cytoplasm In the testis, detected predominantly in elongated spermatids at the late stage of germ cell development and in sperm, with no expression detected in immature germ cells such as spermatogonia and spermatocytes or in somatic cells such as Sertoli cells (at protein level) (PubMed:15810880). Expressed in the head and tail midpiece of elongated spermatids and sperm (at protein level) (PubMed:22237709). Expressed exclusively in the testis (PubMed:15810880, PubMed:22237709). Detected in the testis at low levels at postnatal day 5 but increases at postnatal days 20 and 45 (at protein level). N-glycosylated. Belongs to the ABC transporter superfamily. ABCA family. nucleotide binding lipid transporter activity ATP binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process neutral lipid metabolic process lipid transport membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances intracellular membrane-bounded organelle transmembrane transport uc008avk.1 uc008avk.2 uc008avk.3 
ENSMUST00000121228.2 Elobl ENSMUST00000121228.2 elongin B-like (from RefSeq NM_001360780.1) A6PWE0 A6PWE0_MOUSE ENSMUST00000121228.1 Elobl NM_001360780 uc288bho.1 uc288bho.2 transcription elongation from RNA polymerase II promoter VCB complex elongin complex uc288bho.1 uc288bho.2 
ENSMUST00000121270.8 Leng8 ENSMUST00000121270.8 leukocyte receptor cluster (LRC) member 8, transcript variant 12 (from RefSeq NM_001421723.1) D3YWS8 D3YWS8_MOUSE ENSMUST00000121270.1 ENSMUST00000121270.2 ENSMUST00000121270.3 ENSMUST00000121270.4 ENSMUST00000121270.5 ENSMUST00000121270.6 ENSMUST00000121270.7 Leng8 NM_001421723 uc291ksj.1 uc291ksj.2 uc291ksj.1 uc291ksj.2 
ENSMUST00000121287.8 Rph3al ENSMUST00000121287.8 rabphilin 3A-like (without C2 domains), transcript variant 1 (from RefSeq NM_029548.4) ENSMUST00000121287.1 ENSMUST00000121287.2 ENSMUST00000121287.3 ENSMUST00000121287.4 ENSMUST00000121287.5 ENSMUST00000121287.6 ENSMUST00000121287.7 Gm1753 NM_029548 Noc2 Q768S4 Q9D353 RPH3L_MOUSE uc288agr.1 uc288agr.2 Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A. Acts as a potential RAB3B effector protein in epithelial cells. Recruited to dense-core vesicles through specific interaction with RAB27A in endocrine cells. Interacts with RAB3A, RAB3B, RAB3C and RAB3D. Interacts with ZYX (By similarity). Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Note=Recruited to the exocytic secretory vesicles by RAB27A. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q768S4-1; Sequence=Displayed; Name=2; IsoId=Q768S4-2; Sequence=VSP_023245, VSP_023246; Highly expressed in pancreatic islets. High to moderate expression in adrenal gland, pituitary gland and ovary. The N-terminus of the RabBD domain is necessary and sufficient for interaction with RAB27A. protein binding cytoplasm intracellular protein transport exocytosis membrane Rab GTPase binding regulation of exocytosis regulation of calcium ion-dependent exocytosis secretory granule LIM domain binding transport vesicle membrane secretory granule membrane cytoplasmic vesicle positive regulation of insulin secretion response to drug glucose homeostasis negative regulation of G-protein coupled receptor protein signaling pathway metal ion binding positive regulation of protein secretion uc288agr.1 uc288agr.2 
ENSMUST00000121288.2 Fam167a ENSMUST00000121288.2 family with sequence similarity 167, member A (from RefSeq NM_177628.4) ENSMUST00000121288.1 F167A_MOUSE NM_177628 Q6P1G6 uc007uhr.1 uc007uhr.2 uc007uhr.3 uc007uhr.4 Belongs to the FAM167 (SEC) family. biological_process uc007uhr.1 uc007uhr.2 uc007uhr.3 uc007uhr.4 
ENSMUST00000121291.8 Pex1 ENSMUST00000121291.8 peroxisomal biogenesis factor 1, transcript variant 1 (from RefSeq NM_001293806.1) ENSMUST00000121291.1 ENSMUST00000121291.2 ENSMUST00000121291.3 ENSMUST00000121291.4 ENSMUST00000121291.5 ENSMUST00000121291.6 ENSMUST00000121291.7 NM_001293806 PEX1_MOUSE Pex1 Q3UEC7 Q5BL07 Q9CU85 uc008whe.1 uc008whe.2 uc008whe.3 uc008whe.4 Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Homooligomer; homooligomerizes in the cytosol, interaction with PEX6 promotes dissociation of the homooligomer. Interacts with PEX6; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers. Interacts indirectly with PEX26, via its interaction with PEX6. Cytoplasm, cytosol Peroxisome membrane Note=Associated with peroxisomal membranes; anchored by PEX26 to peroxisome membranes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5BL07-1; Sequence=Displayed; Name=2; IsoId=Q5BL07-2; Sequence=VSP_028131; The N-terminal domain shows evolutionary conservation with that of VCP, and is able to bind phospholipids with a preference for phosphatidylinositol monophosphates. Belongs to the AAA ATPase family. nucleotide binding ATP binding cytoplasm peroxisome peroxisomal membrane cytosol protein targeting to peroxisome peroxisome organization protein C-terminus binding lipid binding protein transport membrane protein import into peroxisome matrix ATPase activity ATPase activity, coupled macromolecular complex binding microtubule-based peroxisome localization uc008whe.1 uc008whe.2 uc008whe.3 uc008whe.4 
ENSMUST00000121325.8 Plagl1 ENSMUST00000121325.8 pleiomorphic adenoma gene-like 1, transcript variant 2 (from RefSeq NM_001364643.1) ENSMUST00000121325.1 ENSMUST00000121325.2 ENSMUST00000121325.3 ENSMUST00000121325.4 ENSMUST00000121325.5 ENSMUST00000121325.6 ENSMUST00000121325.7 NM_001364643 Plagl1 Q3UQW2 Q3UQW2_MOUSE uc007ekl.1 uc007ekl.2 uc007ekl.3 uc007ekl.4 uc007ekl.5 RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding protein binding Golgi apparatus regulation of transcription from RNA polymerase II promoter regulation of gene expression nuclear body skeletal muscle cell differentiation intracellular membrane-bounded organelle positive regulation of transcription from RNA polymerase II promoter uc007ekl.1 uc007ekl.2 uc007ekl.3 uc007ekl.4 uc007ekl.5 
ENSMUST00000121334.8 Septin8 ENSMUST00000121334.8 septin 8, transcript variant 6 (from RefSeq NM_001361969.2) B1AQZ0 B1AQZ0_MOUSE ENSMUST00000121334.1 ENSMUST00000121334.2 ENSMUST00000121334.3 ENSMUST00000121334.4 ENSMUST00000121334.5 ENSMUST00000121334.6 ENSMUST00000121334.7 NM_001361969 Sept8 Septin8 uc057klb.1 uc057klb.2 uc057klb.3 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Presynapse Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. nucleotide binding GTP binding uc057klb.1 uc057klb.2 uc057klb.3 
ENSMUST00000121340.2 Or5g24-ps1 ENSMUST00000121340.2 Or5g24-ps1 (from geneSymbol) ENSMUST00000121340.1 uc289xox.1 uc289xox.2 uc289xox.1 uc289xox.2 
ENSMUST00000121345.4 Or4f4-ps1 ENSMUST00000121345.4 Membrane ; Multi- pass membrane protein (from UniProt A0A286YE47) A0A286YE47 A0A286YE47_MOUSE ENSMUST00000121345.1 ENSMUST00000121345.2 ENSMUST00000121345.3 Or4f4-ps1 uc289zfc.1 uc289zfc.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zfc.1 uc289zfc.2 
ENSMUST00000121369.8 Rnft2 ENSMUST00000121369.8 ring finger protein, transmembrane 2, transcript variant 2 (from RefSeq NM_001109902.1) ENSMUST00000121369.1 ENSMUST00000121369.2 ENSMUST00000121369.3 ENSMUST00000121369.4 ENSMUST00000121369.5 ENSMUST00000121369.6 ENSMUST00000121369.7 NM_001109902 Q3UF64 Q8BXI9 RNFT2_MOUSE Tmem118 uc012ecl.1 uc012ecl.2 uc012ecl.3 E3 ubiquitin-protein ligase that negatively regulates IL3- dependent cellular responses through IL3RA ubiquitination and degradation by the proteasome, having an anti-inflammatory effect. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UF64-1; Sequence=Displayed; Name=2; IsoId=Q3UF64-2; Sequence=VSP_023467; Expression is induced by IL3 and inhibited by LPS. Sequence=AAH57302.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC32896.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE28697.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane metal ion binding uc012ecl.1 uc012ecl.2 uc012ecl.3 
ENSMUST00000121370.8 Tbc1d1 ENSMUST00000121370.8 May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells. (from UniProt Q60949) AK122445 E9QLW9 ENSMUST00000121370.1 ENSMUST00000121370.2 ENSMUST00000121370.3 ENSMUST00000121370.4 ENSMUST00000121370.5 ENSMUST00000121370.6 ENSMUST00000121370.7 Kiaa1108 Q60949 Q80TJ9 Q923F8 TBCD1_MOUSE Tbc1 uc008xml.1 uc008xml.2 uc008xml.3 uc008xml.4 May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells. Interacts with APPL2 (via BAR domain); interaction is dependent of TBC1D1 phosphorylation at Ser-229; interaction diminishes the phosphorylation of TBC1D1 at Thr-590, resulting in inhibition of SLC2A4/GLUT4 translocation and glucose uptake. Q60949; Q8K3G9: Appl2; NbExp=2; IntAct=EBI-21012140, EBI-647007; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60949-1; Sequence=Displayed; Name=2; IsoId=Q60949-2; Sequence=VSP_008473; Expressed in highest levels in hematopoietic cells, testis and kidney. Insulin-stimulated phosphorylation by AKT family kinases stimulates SLC2A4/GLUT4 translocation. Sequence=AAA85223.1; Type=Frameshift; Evidence=; Sequence=BAC65727.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; GTPase activator activity protein binding nucleus cytosol intracellular protein transport Rab GTPase binding regulation of protein localization activation of GTPase activity uc008xml.1 uc008xml.2 uc008xml.3 uc008xml.4 
ENSMUST00000121390.8 Cacna1a ENSMUST00000121390.8 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, transcript variant 1 (from RefSeq NM_007578.3) CAC1A_MOUSE Caca1a Cach4 Cacn3 Cacna1a Cacnl1a4 Ccha1a ENSMUST00000121390.1 ENSMUST00000121390.2 ENSMUST00000121390.3 ENSMUST00000121390.4 ENSMUST00000121390.5 ENSMUST00000121390.6 ENSMUST00000121390.7 NM_007578 P97445 Q2TPN3 uc009mmn.1 uc009mmn.2 uc009mmn.3 uc009mmn.4 Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. P/Q-type calcium channels belong to the 'high- voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP). Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671, ChEBI:CHEBI:29108; Evidence=; Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CABP1 (By similarity).Interacts with the spider omega-agatoxin-IVA (AC P30288) (By similarity). Cell membrane ; Multi-pass membrane protein Brain specific; mainly found in the cerebellum, olfactory bulb, cerebral cortex, hippocampus, and inferior colliculus. In the hippocampus, expression occurs in pyramidal and granule neurons, as well as in interneurons. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage- sensor and are characterized by a series of positively charged amino acids at every third position. Note=Defects in Cacna1a are the cause of a delayed-onset, recessive neurological disorder seen in tottering (tg) mutants, resulting in ataxia, motor seizures and behavioral absence seizures resembling petit mal epilepsy (or absence epilepsy) in humans. There are two more alleles, leaner (tg(lA)), that is characterized by severe ataxia and frequent death past weaning, but no motor seizures; and rolling Nagoya (tg(rol)), that presents an intermediary phenotype, the ataxia being somewhat more severe that with tg, but without motors seizures. Selective degeneration of cerebellar Purkinje cells has been shown for all these types of mutants. Selective degeneration of cerebellar Purkinje cells has been shown for all these types of mutants. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily. regulation of neurotransmitter levels ion channel activity voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity protein binding calmodulin binding nucleus cytoplasm plasma membrane voltage-gated calcium channel complex ion transport calcium ion transport positive regulation of cytosolic calcium ion concentration gamma-aminobutyric acid signaling pathway chemical synaptic transmission neuron-neuron synaptic transmission neuromuscular synaptic transmission synapse assembly adult walking behavior cell death high voltage-gated calcium channel activity regulation of hormone levels gamma-aminobutyric acid secretion regulation of acetylcholine secretion, neurotransmission membrane integral component of membrane calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis transmission of nerve impulse sensory perception of pain syntaxin binding spinal cord motor neuron differentiation cerebellum maturation cerebellar molecular layer development cerebellar Purkinje cell layer development cerebellar Purkinje cell differentiation vestibular nucleus development central nervous system neuron differentiation dendrite cellular chloride ion homeostasis regulation of sulfur amino acid metabolic process negative regulation of hormone biosynthetic process macromolecular complex regulation of ion transmembrane transport synaptic transmission, glutamatergic regulation of membrane potential glucose homeostasis cell projection neuronal cell body receptor clustering perikaryon negative regulation of neuron apoptotic process metal ion binding response to pain behavioral response to pain calcium ion-regulated exocytosis of neurotransmitter dendrite morphogenesis regulation of axonogenesis modulation of synaptic transmission neurological system process musculoskeletal movement, spinal reflex action neuromuscular process controlling balance neuromuscular process membrane depolarization transmembrane transport rhythmic synaptic transmission calcium ion import calcium ion transmembrane transport glutamatergic synapse integral component of presynaptic active zone membrane regulation of presynaptic cytosolic calcium ion concentration voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels regulation of voltage-gated calcium channel activity response to beta-amyloid cellular response to beta-amyloid uc009mmn.1 uc009mmn.2 uc009mmn.3 uc009mmn.4 
ENSMUST00000121391.8 Crybg2 ENSMUST00000121391.8 crystallin beta-gamma domain containing 2 (from RefSeq NM_001162970.1) Aim1l B7ZCC2 B7ZCC2_MOUSE Crybg2 ENSMUST00000121391.1 ENSMUST00000121391.2 ENSMUST00000121391.3 ENSMUST00000121391.4 ENSMUST00000121391.5 ENSMUST00000121391.6 ENSMUST00000121391.7 NM_001162970 uc008vdx.1 uc008vdx.2 uc008vdx.3 Belongs to the beta/gamma-crystallin family. molecular_function cellular_component biological_process uc008vdx.1 uc008vdx.2 uc008vdx.3 
ENSMUST00000121393.9 Gm4631 ENSMUST00000121393.9 Gm4631 (from geneSymbol) A2ART4 A2ART4_MOUSE ENSMUST00000121393.1 ENSMUST00000121393.2 ENSMUST00000121393.3 ENSMUST00000121393.4 ENSMUST00000121393.5 ENSMUST00000121393.6 ENSMUST00000121393.7 ENSMUST00000121393.8 Gm11007 Gm14308 Gm14434 Gm2007 Gm2026 Gm4631 Gm4724 NM_001100415 RP23-376N23.4-001 RP24-574J13.1-003 uc290dch.1 uc290dch.2 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290dch.1 uc290dch.2 
ENSMUST00000121394.3 Prss53 ENSMUST00000121394.3 serine protease 53 (from RefSeq NM_001081268.1) ENSMUST00000121394.1 ENSMUST00000121394.2 NM_001081268 PRS53_MOUSE Q571E5 Q8CFX9 uc009jxd.1 uc009jxd.2 uc009jxd.3 In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator. Secreted Belongs to the peptidase S1 family. Sequence=AAH39632.1; Type=Erroneous initiation; Evidence=; Sequence=BAD90169.1; Type=Erroneous initiation; Evidence=; serine-type endopeptidase activity calcium ion binding extracellular region proteolysis blood coagulation peptidase activity serine-type peptidase activity hydrolase activity uc009jxd.1 uc009jxd.2 uc009jxd.3 
ENSMUST00000121401.8 Simc1 ENSMUST00000121401.8 SUMO-interacting motifs containing 1 (from RefSeq NM_176987.5) E9Q6E9 ENSMUST00000121401.1 ENSMUST00000121401.2 ENSMUST00000121401.3 ENSMUST00000121401.4 ENSMUST00000121401.5 ENSMUST00000121401.6 ENSMUST00000121401.7 NM_176987 Pleiad Q3TM32 Q8C747 Q8CE66 SIMC1_MOUSE uc007qoe.1 uc007qoe.2 uc007qoe.3 uc007qoe.4 Inhibits the protease activity of CAPN3. May play a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SLF2 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication. Forms a heterodimer with SLF2. Interacts (via SIM domains) with SUMO1 and SUMO2. Interacts with CAPN3 and CTBP1. Interacts with SMC6 and ZNF451. Nucleus, PML body Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms may exist. ; Name=1; Synonyms=PLEIADa ; IsoId=E9Q6E9-1; Sequence=Displayed; Name=2; IsoId=E9Q6E9-2; Sequence=VSP_060887, VSP_060888; Skeletal muscle. Sequence=BAC35039.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE38610.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cellular_component biological_process SUMO polymer binding uc007qoe.1 uc007qoe.2 uc007qoe.3 uc007qoe.4 
ENSMUST00000121404.8 Adtrp ENSMUST00000121404.8 androgen dependent TFPI regulating protein, transcript variant 2 (from RefSeq NM_001145875.1) ADTRP_MOUSE D3Z6U0 ENSMUST00000121404.1 ENSMUST00000121404.2 ENSMUST00000121404.3 ENSMUST00000121404.4 ENSMUST00000121404.5 ENSMUST00000121404.6 ENSMUST00000121404.7 NM_001145875 Q3UXS3 Q8C138 Q8K180 uc007qfi.1 uc007qfi.2 uc007qfi.3 Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (By similarity). Shows a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (By similarity). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (By similarity). Reaction=9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy- octadecanoate + H(+) + hexadecanoate; Xref=Rhea:RHEA:52052, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:83670, ChEBI:CHEBI:136286; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52053; Evidence=; Reaction=12-hexadecanoyloxy-octadecanoate + H2O = 12- hydroxyoctadecanoate + H(+) + hexadecanoate; Xref=Rhea:RHEA:52056, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:83677, ChEBI:CHEBI:84201; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52057; Evidence=; Reaction=9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 9-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52068, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:136286, ChEBI:CHEBI:136309; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52069; Evidence=; Reaction=12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 12-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:52072, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:84201, ChEBI:CHEBI:136312; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52073; Evidence=; Reaction=13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 13-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52076, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:136304, ChEBI:CHEBI:136315; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52077; Evidence=; Reaction=9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy- octadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52096, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:136286, ChEBI:CHEBI:136373; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52097; Evidence=; Reaction=12-octadecanoyloxy-octadecanoate + H2O = 12- hydroxyoctadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:84201, ChEBI:CHEBI:136330; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52081; Evidence=; Reaction=13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy- octadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52084, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:136304, ChEBI:CHEBI:136335; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52085; Evidence=; Reaction=9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)- octadecenoate + 9-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52048, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:136282, ChEBI:CHEBI:136286; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52049; Evidence=; Reaction=12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)- octadecenoate + 12-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:52060, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:84201, ChEBI:CHEBI:136302; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52061; Evidence=; Reaction=13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)- octadecenoate + 13-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:136303, ChEBI:CHEBI:136304; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52065; Evidence=; Reaction=5-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)- octadecenoate + 5-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:136370, ChEBI:CHEBI:136389; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52101; Evidence=; Cell membrane ; Multi-pass membrane protein Note=Colocalized with TFPI and CAV1 in lipid rafts. Belongs to the AIG1 family. Sequence=AC165263; Type=Erroneous gene model prediction; Evidence=; Sequence=BAC26250.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; positive regulation of protein phosphorylation cell migration involved in sprouting angiogenesis negative regulation of leukocyte migration negative regulation of extracellular matrix constituent secretion plasma membrane caveola lipid metabolic process cell surface positive regulation of gene expression membrane integral component of membrane hydrolase activity negative regulation of blood coagulation long-chain fatty acid catabolic process protein kinase B signaling negative regulation of protein secretion negative regulation of leukocyte cell-cell adhesion negative regulation of lymphocyte migration uc007qfi.1 uc007qfi.2 uc007qfi.3 
ENSMUST00000121432.4 Or52b6-ps1 ENSMUST00000121432.4 Or52b6-ps1 (from geneSymbol) ENSMUST00000121432.1 ENSMUST00000121432.2 ENSMUST00000121432.3 uc291ttd.1 uc291ttd.2 uc291ttd.1 uc291ttd.2 
ENSMUST00000121438.9 Adam32 ENSMUST00000121438.9 a disintegrin and metallopeptidase domain 32, transcript variant 1 (from RefSeq NM_153397.3) ADA32_MOUSE Adam32 ENSMUST00000121438.1 ENSMUST00000121438.2 ENSMUST00000121438.3 ENSMUST00000121438.4 ENSMUST00000121438.5 ENSMUST00000121438.6 ENSMUST00000121438.7 ENSMUST00000121438.8 NM_153397 Q6P901 Q8BJ80 Q8K410 uc009lfh.1 uc009lfh.2 uc009lfh.3 uc009lfh.4 This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene was found to be expressed predominantly in the pachytene spermatocytes, where the processed protein is localized to the sperm surface. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]. May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K410-1; Sequence=Displayed; Name=2; IsoId=Q8K410-2; Sequence=VSP_012052; Expressed in sperm (at protein level) (PubMed:20945367). Highly expressed in the testis and weakly expressed in the epididymis, brain and heart (PubMed:12568724). Initially expressed in the testis at day 16 and reaches adult expression levels by day 30 after birth. Sequence=AAH60983.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAN03858.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; metalloendopeptidase activity cellular_component proteolysis metallopeptidase activity membrane integral component of membrane uc009lfh.1 uc009lfh.2 uc009lfh.3 uc009lfh.4 
ENSMUST00000121440.4 Maml3 ENSMUST00000121440.4 mastermind like transcriptional coactivator 3 (from RefSeq NM_001004176.3) D4QGC2 D4QGC2_MOUSE ENSMUST00000121440.1 ENSMUST00000121440.2 ENSMUST00000121440.3 Mam-2 Maml3 NM_001004176 uc008pef.1 uc008pef.2 uc008pef.3 uc008pef.4 uc008pef.5 Nucleus speckle Belongs to the mastermind family. transcription coactivator activity nucleus nucleoplasm Notch signaling pathway positive regulation of transcription of Notch receptor target nuclear speck positive regulation of transcription from RNA polymerase II promoter uc008pef.1 uc008pef.2 uc008pef.3 uc008pef.4 uc008pef.5 
ENSMUST00000121442.2 Iqcc ENSMUST00000121442.2 Iqcc (from geneSymbol) A8Y5J7 A8Y5J7_MOUSE BC031493 ENSMUST00000121442.1 Iqcc uc290qdt.1 uc290qdt.2 uc290qdt.1 uc290qdt.2 
ENSMUST00000121465.3 Fuca2 ENSMUST00000121465.3 fucosidase, alpha-L- 2, plasma, transcript variant 1 (from RefSeq NM_025799.5) ENSMUST00000121465.1 ENSMUST00000121465.2 FUCO2_MOUSE NM_025799 Q8VEM3 Q99KR8 Q9D7Z8 Q9DCL7 uc007ekw.1 uc007ekw.2 uc007ekw.3 Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Reaction=an alpha-L-fucoside + H2O = an alcohol + L-fucose; Xref=Rhea:RHEA:12288, ChEBI:CHEBI:2181, ChEBI:CHEBI:15377, ChEBI:CHEBI:28349, ChEBI:CHEBI:30879; EC=3.2.1.51; Evidence=; Homotetramer. Secreted Belongs to the glycosyl hydrolase 29 family. alpha-L-fucosidase activity extracellular region extracellular space lysosome carbohydrate metabolic process fucose metabolic process metabolic process response to bacterium glycoside catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds regulation of entry of bacterium into host cell uc007ekw.1 uc007ekw.2 uc007ekw.3 
ENSMUST00000121469.2 Reep1 ENSMUST00000121469.2 receptor accessory protein 1 (from RefSeq NM_178608.4) D6Ertd253e ENSMUST00000121469.1 NM_178608 Q8BGH4 REEP1_MOUSE uc009chc.1 uc009chc.2 uc009chc.3 uc009chc.4 uc009chc.5 Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (By similarity). Interacts with OLFR992 (PubMed:15550249). Interacts with SPAST and ATL1. Interacts (via C-terminus) with microtubules (By similarity). Interacts with ZFYVE27 (PubMed:24668814). Membrane Mitochondrion membrane ; Multi-pass membrane protein Endoplasmic reticulum Note=A small proportion is detected at the cell surface. Localizes to endoplasmic reticulum tubular network. Detected in olfactory sensory neurons of the olfactory epithelium, and in total brain. Belongs to the DP1 family. protein binding cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane microtubule binding membrane integral component of membrane olfactory receptor binding mitochondrial membrane regulation of intracellular transport protein insertion into membrane endoplasmic reticulum tubular network endoplasmic reticulum tubular network organization plasma membrane uc009chc.1 uc009chc.2 uc009chc.3 uc009chc.4 uc009chc.5 
ENSMUST00000121473.8 Erbb4 ENSMUST00000121473.8 erb-b2 receptor tyrosine kinase 4 (from RefSeq NM_010154.2) B2KGF5 B2KGF6 ENSMUST00000121473.1 ENSMUST00000121473.2 ENSMUST00000121473.3 ENSMUST00000121473.4 ENSMUST00000121473.5 ENSMUST00000121473.6 ENSMUST00000121473.7 ERBB4_MOUSE Mer4 NM_010154 O88460 Q3UNS6 Q61527 uc007bjb.1 uc007bjb.2 uc007bjb.3 uc007bjb.4 Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context- specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM- A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Binding of a cognate ligand leads to dimerization and activation by autophosphorylation on tyrosine residues. In vitro kinase activity is increased by Mg(2+) (By similarity). Monomer in the absence of bound ligand. Homodimer or heterodimer with another ERBB family member upon ligand binding, thus forming heterotetramers. Interacts with EGFR and ERBB2. Interacts with DLG2 (via its PDZ domain), DLG3 (via its PDZ domain), DLG4 (via its PDZ domain) and SNTB2 (via its PDZ domain). Interacts with MUC1. Interacts (via its PPxy motifs) with WWOX. Interacts (via the PPxY motif 3 of isoform JM-A CYT-2) with YAP1 (via the WW domain 1 of isoform 1). Interacts (isoform JM-A CYT-1 and isoform JM-B CYT-1) with WWP1. Interacts (via its intracellular domain) with TRIM28. Interacts (via the intracellular domains of both CYT-1 and CYT-2 isoforms) with KAP1; the interaction does not phosphorylate KAP1 but represses ERBB4- mediated transcriptional activity. Interacts with PRPU, DDX23, MATR3, RBM15, ILF3, KAP1, U5S1, U2SURP, ITCH, HNRNPU, AP2A1, NULC, LEO1, WWP2, IGHG1, HXK1, GRB7 and SRRT. Interacts (phosphorylated isoform JM-A CYT- 1 and isoform JM-B CYT-1) with PIK3R1. Interacts with SHC1. Interacts with GRB2. Interacts (soluble intracellular domain) with BCL2. Interacts (phosphorylated) with STAT1 (By similarity). Interacts with CBFA2T3. Interacts (soluble intracellular domain) with STAT5A. Q61527; Q9NZC7: WWOX; Xeno; NbExp=3; IntAct=EBI-4398741, EBI-4320739; Cell membrane ; Single-pass type I membrane protein Note=In response to NRG1 treatment, the activated receptor is internalized. [ERBB4 intracellular domain]: Nucleus. Mitochondrion Note=Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD2 colocalizes with YAP1 in the nucleus (By similarity). Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=JM-A CYT-1; IsoId=Q61527-1; Sequence=Displayed; Name=JM-B CYT-2; IsoId=Q61527-2; Sequence=VSP_002896; Name=JM-A CYT-2; IsoId=Q61527-3; Sequence=VSP_042131; Isoform JM-A CYT-2 and isoform JM-B CYT-2 are expressed in cerebellum, cerebral cortex, spinal cord, medulla oblongata and eye, but the kidney expresses solely isoform JM-A CYT-2 and the heart solely isoform JM-B CYT-2. Isoform JM-A CYT-1 and isoform JM-A CYT-2 are processed by ADAM17. Proteolytic processing in response to ligand or 12-O- tetradecanoylphorbol-13-acetate stimulation results in the production of 120 kDa soluble receptor forms and intermediate membrane-anchored 80 kDa fragments (m80HER4), which are further processed by a presenilin- dependent gamma-secretase to release a cytoplasmic intracellular domain (E4ICD; E4ICD1/s80Cyt1 or E4ICD2/s80Cyt2, depending on the isoform). Membrane-anchored 80 kDa fragments of the processed isoform JM-A CYT-1 are more readily degraded by the proteasome than fragments of isoform JM-A CYT-2, suggesting a prevalence of E4ICD2 over E4ICD1. Isoform JM-B CYT-1 and isoform JM-B CYT-2 lack the ADAM17 cleavage site and are not processed by ADAM17, precluding further processing by gamma-secretase (By similarity). Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Ligands trigger phosphorylation at specific tyrosine residues, thereby creating binding sites for scaffold proteins and effectors. Constitutively phosphorylated at a basal level when overexpressed in heterologous systems; ligand binding leads to increased phosphorylation. Phosphorylation at Tyr-1035 is important for interaction with STAT1. Phosphorylation at Tyr-1056 is important for interaction with PIK3R1. Phosphorylation at Tyr-1242 is important for interaction with SHC1. Phosphorylation at Tyr-1188 may also contribute to the interaction with SHC1. Isoform JM-A CYT-2 is constitutively phosphorylated on tyrosine residues in a ligand-independent manner. E4ICD2 but not E4ICD1 is phosphorylated on tyrosine residues (By similarity). Ubiquitinated. During mitosis, the ERBB4 intracellular domain is ubiquitinated by the APC/C complex and targeted to proteasomal degradation. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are ubiquitinated by WWP1. The ERBB4 intracellular domain (E4ICD1) is ubiquitinated, and this involves NEDD4 (By similarity). Embryonically lethal. Embryos die at about 10 dpc, due to defects in the development of myocardial trabeculae in the heart ventricle that lead to severely reduced embryonic blood flow. Mice also display aberrant innervation from and to the hindbrain, especially concerning the trigeminal, facial and acoustic ganglia. This is due to aberrant migration of a subpopulation of cranial neural crest cells. [Isoform JM-A CYT-1]: Proteolytical processing generates E4ICD1 (s80Cyt1). [Isoform JM-A CYT-2]: Proteolytical processing generates E4ICD2 (s80Cyt2). Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. nucleotide binding neural crest cell migration protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity epidermal growth factor receptor binding protein binding ATP binding nucleus cytoplasm mitochondrion plasma membrane integral component of plasma membrane caveola protein phosphorylation apoptotic process signal transduction transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development synapse assembly heart development lactation positive regulation of cell proliferation negative regulation of cell proliferation embryonic pattern specification basal plasma membrane negative regulation of muscle cell apoptotic process positive regulation of phosphatidylinositol 3-kinase signaling postsynaptic density membrane integral component of membrane kinase activity phosphorylation basolateral plasma membrane cell migration transferase activity peptidyl-tyrosine phosphorylation central nervous system morphogenesis olfactory bulb interneuron differentiation regulation of cell migration positive regulation of cell migration positive regulation of synaptic transmission, GABAergic peptidyl-tyrosine autophosphorylation neuregulin binding positive regulation of tyrosine phosphorylation of STAT protein protein homodimerization activity positive regulation of apoptotic process negative regulation of apoptotic process surfactant homeostasis receptor complex positive regulation of phosphatidylinositol 3-kinase activity mitochondrial fragmentation involved in apoptotic process transcription regulatory region DNA binding membrane raft cell fate commitment postsynaptic membrane positive regulation of transcription, DNA-templated positive regulation of glucose import positive regulation of JAK-STAT cascade protein autophosphorylation positive regulation of epithelial cell proliferation positive regulation of cardiac muscle cell proliferation synapse maturation mammary gland epithelial cell differentiation mammary gland alveolus development cardiac muscle tissue regeneration positive regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus glutamatergic synapse GABA-ergic synapse integral component of presynaptic membrane integral component of postsynaptic density membrane positive regulation of protein localization to cell surface negative regulation of neuron migration uc007bjb.1 uc007bjb.2 uc007bjb.3 uc007bjb.4 
ENSMUST00000121503.8 Tpm3 ENSMUST00000121503.8 tropomyosin 3, gamma, transcript variant 2 (from RefSeq NM_001293748.1) A0A0R4J1P2 A0A0R4J1P2_MOUSE ENSMUST00000121503.1 ENSMUST00000121503.2 ENSMUST00000121503.3 ENSMUST00000121503.4 ENSMUST00000121503.5 ENSMUST00000121503.6 ENSMUST00000121503.7 NM_001293748 Tpm3 uc008qbf.1 uc008qbf.2 uc008qbf.3 uc008qbf.4 uc008qbf.5 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Cytoplasm, cytoskeleton Belongs to the tropomyosin family. uc008qbf.1 uc008qbf.2 uc008qbf.3 uc008qbf.4 uc008qbf.5 
ENSMUST00000121534.8 Cops7b ENSMUST00000121534.8 COP9 signalosome subunit 7B, transcript variant 1 (from RefSeq NM_172974.3) CSN7B_MOUSE Csn7b ENSMUST00000121534.1 ENSMUST00000121534.2 ENSMUST00000121534.3 ENSMUST00000121534.4 ENSMUST00000121534.5 ENSMUST00000121534.6 ENSMUST00000121534.7 NM_172974 O88547 Q3TGG7 Q8BV13 Q921G4 uc287kav.1 uc287kav.2 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with EIF3S6 (By similarity). Cytoplasm Nucleus Belongs to the CSN7/EIF3M family. CSN7 subfamily. protein deneddylation molecular_function nucleus nucleoplasm cytoplasm COP9 signalosome COP9 signalosome assembly uc287kav.1 uc287kav.2 
ENSMUST00000121542.2 Eme2 ENSMUST00000121542.2 essential meiotic structure-specific endonuclease subunit 2 (from RefSeq NM_001163102.1) EME2_MOUSE ENSMUST00000121542.1 NM_001163102 Q56A04 uc008ayw.1 uc008ayw.2 uc008ayw.3 Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. Interacts with MUS81. Nucleus Belongs to the EME1/MMS4 family. resolution of meiotic recombination intermediates nuclear chromatin DNA binding nuclease activity endonuclease activity nucleus DNA repair double-strand break repair DNA recombination cellular response to DNA damage stimulus hydrolase activity replication fork processing intra-S DNA damage checkpoint Holliday junction resolvase complex nucleic acid phosphodiester bond hydrolysis crossover junction endodeoxyribonuclease activity uc008ayw.1 uc008ayw.2 uc008ayw.3 
ENSMUST00000121565.8 AU015836 ENSMUST00000121565.8 expressed sequence AU015836 (from RefSeq NR_028320.1) AU015836 B1ASY6 B1ASY6_MOUSE ENSMUST00000121565.1 ENSMUST00000121565.2 ENSMUST00000121565.3 ENSMUST00000121565.4 ENSMUST00000121565.5 ENSMUST00000121565.6 ENSMUST00000121565.7 NR_028320 uc292pks.1 uc292pks.2 mitochondrial intermembrane space protein disulfide oxidoreductase activity protein maturation by protein folding protein import into mitochondrial intermembrane space oxidation-reduction process uc292pks.1 uc292pks.2 
ENSMUST00000121584.8 Prdm15 ENSMUST00000121584.8 PR domain containing 15, transcript variant 14 (from RefSeq NR_175377.1) E9Q6A1 E9Q8T2 ENSMUST00000121584.1 ENSMUST00000121584.2 ENSMUST00000121584.3 ENSMUST00000121584.4 ENSMUST00000121584.5 ENSMUST00000121584.6 ENSMUST00000121584.7 NR_175377 PRD15_MOUSE Prdm15 Q3UML7 uc008adq.1 uc008adq.2 uc008adq.3 uc008adq.4 Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Also plays a role in induced pluripotent stem cells (iPSCs) reprogramming. Involved in early embryo development. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q8T2-1; Sequence=Displayed; Name=2; IsoId=E9Q8T2-2; Sequence=VSP_059647; Expressed in embryonic stem cells (ESCs) (at protein level). Mice die before birth and show early postimplantation developmental defect. Display reduced embryonic stem cells (ESCs) proliferation and self-renewal capacity. Show altered transcription of naive pluripotency and self-renewal modulator genes. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm multicellular organism development methyltransferase activity nuclear body transferase activity chromatin DNA binding methylation negative regulation of MAPK cascade sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of canonical Wnt signaling pathway promoter-specific chromatin binding regulation of stem cell division uc008adq.1 uc008adq.2 uc008adq.3 uc008adq.4 
ENSMUST00000121598.8 Apoa5 ENSMUST00000121598.8 apolipoprotein A-V, transcript variant 2 (from RefSeq NM_001348095.1) APOA5_MOUSE ENSMUST00000121598.1 ENSMUST00000121598.2 ENSMUST00000121598.3 ENSMUST00000121598.4 ENSMUST00000121598.5 ENSMUST00000121598.6 ENSMUST00000121598.7 NM_001348095 Q8C7G5 Q91X90 Q99P64 Rap3 uc009phg.1 uc009phg.2 uc009phg.3 Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity). Binds heparin (By similarity). Interacts with GPIHBP1 (By similarity). Interacts with SORL1; this interaction leads to APOA5 internalization and sorting either to lysosomes and degradation, or to the trans-Golgi network (By similarity). Secreted Early endosome Late endosome Golgi apparatus, trans-Golgi network Note=In the presence of SORL1, internalized to early endosomes, sorted in a retrograde fashion to late endosomes, from which a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network. Liver. Induced in early phase of liver regeneration. Phosphorylated by FAM20C in the extracellular medium. Mice expressing the human APOAV transgene show a decrease in plasma TG by one third. Conversely, knockout mice lacking APOAV have a four time increase in plasma TG. Belongs to the apolipoprotein A1/A4/E family. phospholipid binding extracellular region extracellular space endosome early endosome late endosome Golgi apparatus cytosol triglyceride metabolic process cholesterol biosynthetic process lipid transport enzyme activator activity heparin binding lipid binding positive regulation of cholesterol esterification positive regulation of triglyceride catabolic process positive regulation of very-low-density lipoprotein particle remodeling cholesterol binding triglyceride catabolic process enzyme binding regulation of intestinal cholesterol absorption phosphatidylcholine binding cholesterol efflux phospholipid efflux very-low-density lipoprotein particle high-density lipoprotein particle triglyceride-rich lipoprotein particle remodeling very-low-density lipoprotein particle remodeling high-density lipoprotein particle assembly lipase binding lipoprotein metabolic process tissue regeneration chylomicron cholesterol homeostasis positive regulation of fatty acid biosynthetic process phosphatidylcholine metabolic process low-density lipoprotein particle receptor binding positive regulation of lipid catabolic process positive regulation of lipoprotein lipase activity acylglycerol homeostasis phosphatidylcholine-sterol O-acyltransferase activator activity lipase activator activity lipoprotein lipase activator activity lipoprotein particle receptor binding triglyceride homeostasis uc009phg.1 uc009phg.2 uc009phg.3 
ENSMUST00000121608.3 4930595D18Rik ENSMUST00000121608.3 RIKEN cDNA 4930595D18 gene (from RefSeq NR_130987.1) ENSMUST00000121608.1 ENSMUST00000121608.2 NR_130987 uc056ysk.1 uc056ysk.2 uc056ysk.3 uc056ysk.4 uc056ysk.1 uc056ysk.2 uc056ysk.3 uc056ysk.4 
ENSMUST00000121614.2 Or13c9 ENSMUST00000121614.2 Or13c9 (from geneSymbol) ENSMUST00000121614.1 NR_190799 uc290msx.1 uc290msx.2 uc290msx.1 uc290msx.2 
ENSMUST00000121623.8 Kxd1 ENSMUST00000121623.8 Component of the 60S subunit of the ribosome. (from UniProt E9QNP0) 2810422J05Rik BC054413 E9QNP0 E9QNP0_MOUSE ENSMUST00000121623.1 ENSMUST00000121623.2 ENSMUST00000121623.3 ENSMUST00000121623.4 ENSMUST00000121623.5 ENSMUST00000121623.6 ENSMUST00000121623.7 Kxd1 uc292apg.1 uc292apg.2 Component of the 60S subunit of the ribosome. Part of the 60S ribosomal subunit. Belongs to the KXD1 family. In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family. In the N-terminal section; belongs to the ubiquitin family. structural constituent of ribosome ribosome translation uc292apg.1 uc292apg.2 
ENSMUST00000121629.8 Mybpc1 ENSMUST00000121629.8 myosin binding protein C, slow-type, transcript variant 2 (from RefSeq NM_175418.5) 8030451F13Rik ENSMUST00000121629.1 ENSMUST00000121629.2 ENSMUST00000121629.3 ENSMUST00000121629.4 ENSMUST00000121629.5 ENSMUST00000121629.6 ENSMUST00000121629.7 Mybpc1 NM_175418 Q6P6L5 Q6P6L5_MOUSE uc007grt.1 uc007grt.2 uc007grt.3 uc007grt.4 Belongs to the immunoglobulin superfamily. MyBP family. structural constituent of cytoskeleton cytoskeleton muscle contraction cytoskeleton organization uc007grt.1 uc007grt.2 uc007grt.3 uc007grt.4 
ENSMUST00000121652.8 Orai1 ENSMUST00000121652.8 ORAI calcium release-activated calcium modulator 1 (from RefSeq NM_175423.3) CRCM1_MOUSE Cracm1 ENSMUST00000121652.1 ENSMUST00000121652.2 ENSMUST00000121652.3 ENSMUST00000121652.4 ENSMUST00000121652.5 ENSMUST00000121652.6 ENSMUST00000121652.7 NM_175423 Q8BUD4 Q8BWG9 Q8R586 Tmem142a uc008zmy.1 uc008zmy.2 uc008zmy.3 Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (By similarity). Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion (PubMed:23840669) (By similarity). Oxidation at Cys-197 leads to inactivation of channel activity. Interacts with STIM1 and STIM2; this regulates channel activity. Interacts with CALM; this may displace STIM1 and STIM2 and might thereby modulate channel activity. Interacts with CRACR2A/EFCAB4B; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with CRACR2A/EFCAB4B and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with SLC35G1. Interacts with UBQLN1. Interacts with ADCY8; interaction is calcium store depletion independent; interaction occurs in membrane raft; interaction increases markedly after store depletion; positively regulates SOCE-induced adenylate cyclase activity; contributes to the targeting of ADCY8 to discrete regions of the plasma membrane that are shielded from other calcium events (By similarity). Interacts with EFHB; the interaction takes place upon Ca(2+)-store depletion (By similarity). Interacts (via N- and C-termini) with ATP2C2 (via N-terminus); this interaction regulates Ca(2+) influx at the plasma membrane. Interacts with TSPAN18; this interaction regulates ORAI1 exit from the endoplasmic (ER), and/or Golgi, and trafficking to the cell surface (By similarity). Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Note=Colocalizes with STIM1 at the cell membrane. Expressed in lactating mammary epithelium (at protein level). N-glycosylated. N-glycosylation inhibits channel activity. Ubiquitinated. Cys-197 is oxidated, leading to inactivation of channel activity. Belongs to the Orai family. According to a report, ORAI1 has been shown to colocalize with UBQLN1 in the autophagosome as a target for autophagic degradation; ORAI1 is however not an autophagosomal protein. Sequence=AAH23149.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; store-operated calcium entry adaptive immune response immune system process calcium channel activity protein binding calmodulin binding autophagosome cytosol plasma membrane integral component of plasma membrane ion transport calcium ion transport store-operated calcium channel activity membrane integral component of membrane basolateral plasma membrane growth cone cytoplasmic vesicle macromolecular complex identical protein binding plasma membrane raft membrane raft positive regulation of adenylate cyclase activity regulation of calcium ion transport positive regulation of calcium ion transport mammary gland epithelium development calcium ion import calcium ion transmembrane transport uc008zmy.1 uc008zmy.2 uc008zmy.3 
ENSMUST00000121674.9 Poli ENSMUST00000121674.9 polymerase (DNA directed), iota, transcript variant 2 (from RefSeq NM_011972.3) E9QJU6 E9QJU6_MOUSE ENSMUST00000121674.1 ENSMUST00000121674.2 ENSMUST00000121674.3 ENSMUST00000121674.4 ENSMUST00000121674.5 ENSMUST00000121674.6 ENSMUST00000121674.7 ENSMUST00000121674.8 NM_011972 Poli uc008fok.1 uc008fok.2 uc008fok.3 uc008fok.4 damaged DNA binding DNA repair nuclear speck cytoplasmic ribonucleoprotein granule uc008fok.1 uc008fok.2 uc008fok.3 uc008fok.4 
ENSMUST00000121693.8 Rab27b ENSMUST00000121693.8 RAB27B, member RAS oncogene family, transcript variant 2 (from RefSeq NM_001082553.2) ENSMUST00000121693.1 ENSMUST00000121693.2 ENSMUST00000121693.3 ENSMUST00000121693.4 ENSMUST00000121693.5 ENSMUST00000121693.6 ENSMUST00000121693.7 NM_001082553 Q8CIX0 Q99P58 RB27B_MOUSE uc008foa.1 uc008foa.2 uc008foa.3 Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Activated by GEFs such as DENND10. Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A. Interacts (GDP-bound form preferentially) with DENND10 (By similarity). Q99P58; Q91V27: Mlph; NbExp=2; IntAct=EBI-11565917, EBI-398308; Membrane ; Lipid- anchor Late endosome Expressed abundantly in the stomach and is predominantly localized at the apical region of gastric-surface mucus cells. Also expressed in the brain and spleen. Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity protein binding GTP binding late endosome Golgi apparatus Golgi stack intracellular protein transport membrane apical plasma membrane regulation of exocytosis GDP binding protein domain specific binding trans-Golgi network transport vesicle secretory granule secretory granule membrane myosin V binding melanosome transport Rab protein signal transduction multivesicular body membrane melanosome zymogen granule membrane positive regulation of exocytosis synaptic vesicle endocytosis multivesicular body sorting pathway anchored component of synaptic vesicle membrane anterograde axonal protein transport axon cytoplasm uc008foa.1 uc008foa.2 uc008foa.3 
ENSMUST00000121720.2 Nap1l2 ENSMUST00000121720.2 nucleosome assembly protein 1-like 2 (from RefSeq NM_008671.3) Bpx ENSMUST00000121720.1 NM_008671 NP1L2_MOUSE P51860 Q8K3R9 uc009tzi.1 uc009tzi.2 uc009tzi.3 uc009tzi.4 Acidic protein which may be involved in interactions with other proteins or DNA. P51860; Q9UHL9: GTF2IRD1; Xeno; NbExp=3; IntAct=EBI-12516895, EBI-372530; Nucleus Brain, specifically expressed in neurons. First expressed around the day 7 embryo. Belongs to the nucleosome assembly protein (NAP) family. chromatin binding protein binding nucleus nucleosome assembly positive regulation of histone acetylation histone binding positive regulation of neuron differentiation positive regulation of histone H3-K14 acetylation regulation of stem cell division positive regulation of histone H3-K9 acetylation uc009tzi.1 uc009tzi.2 uc009tzi.3 uc009tzi.4 
ENSMUST00000121743.2 Tmc4 ENSMUST00000121743.2 Membrane ulti-pass membrane protein (from UniProt D3YWB3) AK050105 D3YWB3 D3YWB3_MOUSE ENSMUST00000121743.1 Tmc4 uc009evn.1 uc009evn.2 uc009evn.3 Membrane ulti-pass membrane protein Belongs to the TMC family. integral component of plasma membrane membrane integral component of membrane uc009evn.1 uc009evn.2 uc009evn.3 
ENSMUST00000121758.8 Ano1 ENSMUST00000121758.8 anoctamin 1, calcium activated chloride channel, transcript variant 1 (from RefSeq NM_178642.6) ANO1_MOUSE ENSMUST00000121758.1 ENSMUST00000121758.2 ENSMUST00000121758.3 ENSMUST00000121758.4 ENSMUST00000121758.5 ENSMUST00000121758.6 ENSMUST00000121758.7 NM_178642 Q6P5C6 Q8BHY3 Q8BI26 Q99JK1 Tmem16a uc009kqn.1 uc009kqn.2 uc009kqn.3 uc009kqn.4 Calcium-activated chloride channel (CaCC) (PubMed:28561733, PubMed:29236691, PubMed:29236684, PubMed:25779870, PubMed:28963502, PubMed:22634729, PubMed:31147466, PubMed:34433575, PubMed:34089532, PubMed:24913262, PubMed:35135993, PubMed:23840801). Plays a role in transepithelial anion transport and smooth muscle contraction (PubMed:28561733, PubMed:29236691, PubMed:29236684). Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression (By similarity). Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (PubMed:30586313). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (By similarity). However, was shown in another study not to be required for MUC5AC expression (By similarity). Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (PubMed:35129434). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (PubMed:34433575). Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae (PubMed:34089532). Acts as a heat sensor in nociceptive neurons (PubMed:22634729). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (PubMed:35135993). In the developing brain, required for the Ca(2+)- dependent process extension of radial glial cells (PubMed:31147466). ATP and calmodulin are essential for its activation. Channel activity is inhibited by CFTR protein and by chloride inhibitors such as niflumic acid (NFA) and 4,4'- diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) (By similarity). Activated by heat with activation seen at temperatures above 44 degrees Celsius (PubMed:22634729). Activated by BDNF in radial glial cells (PubMed:31147466). Homodimer (PubMed:28561733, PubMed:29236691, PubMed:29236684). Interacts with CFTR (By similarity). Interacts with TRPV4 (PubMed:24509911). Q8BHY3; Q8BHY3: Ano1; NbExp=2; IntAct=EBI-11795280, EBI-11795280; Apical cell membrane ulti-pass membrane protein esynapse Note=In differentiating airway epithelial cells, predominantly intracellular at day 0 but is apically localized by day 30 (By similarity). Expressed in the presynapse of retinal neurons (PubMed:23840801). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BHY3-1; Sequence=Displayed; Name=2; IsoId=Q8BHY3-2; Sequence=VSP_025672; Expressed at the apical surface of the vomeronasal epithelium (at protein level) (PubMed:25779870, PubMed:34433575). Expressed in the lateral and septal nasal glands (at protein level) (PubMed:25779870). Highly expressed in pulmonary bronchiole epithelial cells, pancreatic and submandibular gland acinar cells, kidney proximal tubule, all retinal cell layers, most sensory cells of dorsal root ganglia, Leydig cells and spermatocytes (at protein level). In the dorsal root ganglia, detected in small-diameter nociceptive neurons and in larger myelinated neurons (at protein level) (PubMed:22634729). In the dorsal root ganglia, expressed in MrgprA3-positive neurons (at protein level) (PubMed:35135993). In the developing brain, highly expressed in the ventricular zone and subventricular zone at 12.5 dpc and 14.5 dpc where it is detected in radial glial cells but not in neurons with expression dramatically decreased at P1 (at protein level) (PubMed:31147466). Highly expressed in the endometrial stroma (at protein level) (PubMed:31175367). In taste buds of the vallate papillae, expressed in the apical region of type I taste cells (at protein level) (PubMed:34089532). In the kidney, expressed in the collecting duct (at protein level) (PubMed:24913262). In the retina, strongly expressed in the outer and inner plexiform layers, weakly expressed in some somata in the inner nuclear layer and ganglion cell layer and not expressed in the outer nuclear layer (at protein level) (PubMed:23840801). Expressed in various retinal neurons including rod bipolar cells (at protein level) (PubMed:23840801). Expressed in eye, brain, myometrium and endometrium with higher levels in endometrium than myometrium in estrus and day 18 pregnant mice (PubMed:31175367). Not detected in uterine smooth muscle cells (PubMed:31175367). Expressed at high levels in the thyroid gland and gastrointestinal muscles. In the developing respiratory system, expressed in epithelium of trachea and lung at 12.5 dpc and 14.5 dpc but not detected in distal epithelial tips. Expressed in the mesenchyme adjacent to the proximal conducting airway epithelium at 14.5 dpc but not at 16.5 dpc. Epithelial expression persists at 16.5 dpc. At 18.5 dpc, high levels detected only in epithelial cells of terminal sacules. In the developing gastrointestinal tract, expressed in the esophageal mesenchyme and epithelium of posterior stomach and intestine. In the developing skeleton, expressed in the perichondria of the neural arch of developing vertebrae at 14.5 dpc and 16.5 dpc. In developing skin, expression is restricted to basal layers of the epidermis at 16.5 dpc. The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region. Mice display severe tracheomalacia with gaps in the tracheal cartilage rings along the entire length of the trachea (PubMed:18585372). 90% of mutants die within the first nine days of postnatal life and no mutants survive longer than 30 days postpartum (PubMed:18585372). Embryonic radial glial cells exhibit significantly shorter processes and mutant embryos display abnormal cortical organization and decreased cortical thickness (PubMed:31147466). Conditional knockout in mature vomeronasal sensory neurons abolishes calcium-activated chloride currents but does not affect Tmem16b expression or glomerular development in the accessory olfactory bulb (PubMed:25779870, PubMed:34433575). Conditional knockout in intestinal and respiratory epithelial cells abolishes both calcium-activated chloride channel activity and CFTR-dependent chloride secretion (PubMed:28963502). Conditional knockout in ciliated airway epithelial cells results in inhibition of basal airway mucus secretion with accumulation of mucus in airway club cells (PubMed:30586313). Conditional knockout in intestinal epithelial cells results in accumulation of mucus in both large and small intestinal goblet cells (PubMed:30586313). Conditional knockout in Syn1-expressing cells results in impaired social behavior, depressive-like behavior and decreased weight but does not affect locomotor activity, cognitive function or motor coordination (PubMed:29928889). Conditional knockout in dorsal root ganglion neurons results in reduction of heat-sensitive Cl- currents and a pronounced analgesic effect in response to heat (PubMed:22634729). Conditional knockout in dorsal root ganglion neurons results in reduced Mas-related G-protein coupled receptor-dependent itching (PubMed:35135993). Conditional knockout in the inner ear does not affect morphological development of the organ of Corti but impairs pre-hearing cochlear activity and spontaneous burst firing as well as sensitivity and frequency selectivity of sound-evoked firing of neurons of the medial nucleus of the trapezoid body (MNTB) (PubMed:35129434). Conditional knockout in smooth muscle cells does not alter Ca2+ signaling, uterine contraction, gestation length, or litter size (PubMed:31175367). RNAi-mediated knockdown reduces calcium-activated chloride currents and saliva production (PubMed:18724360). RNAi- mediated knockdown results in a pronounced analgesic effect in response to heat (PubMed:22634729). The term 'anoctamin' was coined because these channels are anion selective and are predicted to have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. Belongs to the anoctamin family. Contains ten transmembrane regions, not eight as predicted. Sequence=AAH06062.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC26230.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC26398.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC35051.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; calcium activated cation channel activity intracellular calcium activated chloride channel activity voltage-gated chloride channel activity chloride channel activity cytoplasm plasma membrane integral component of plasma membrane ion transport cation transport chloride transport phospholipase C-activating G-protein coupled receptor signaling pathway multicellular organism development external side of plasma membrane iodide transmembrane transporter activity iodide transport membrane integral component of membrane apical plasma membrane cellular response to heat chloride channel complex positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of membrane potential protein homodimerization activity metal ion binding protein heterodimerization activity protein dimerization activity detection of temperature stimulus involved in sensory perception of pain trachea development chloride transmembrane transport detection of mechanical stimulus involved in sensory perception of pain uc009kqn.1 uc009kqn.2 uc009kqn.3 uc009kqn.4 
ENSMUST00000121777.9 Lins1 ENSMUST00000121777.9 lines homolog 1, transcript variant 1 (from RefSeq NM_152815.2) ENSMUST00000121777.1 ENSMUST00000121777.2 ENSMUST00000121777.3 ENSMUST00000121777.4 ENSMUST00000121777.5 ENSMUST00000121777.6 ENSMUST00000121777.7 ENSMUST00000121777.8 LINES_MOUSE Lins Lins1 Lins2 NM_152815 Q3TBL8 Q3U1D0 Q6PCP6 Q8K4P9 Wins2 uc012fmu.1 uc012fmu.2 uc012fmu.3 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U1D0-1; Sequence=Displayed; Name=2; Synonyms=Wins2; IsoId=Q3U1D0-2; Sequence=VSP_039707; Name=3; IsoId=Q3U1D0-3; Sequence=VSP_039708; Belongs to the protein lines family. Sequence=AAH59228.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH59228.1; Type=Miscellaneous discrepancy; Note=Probable intron retention.; Evidence=; molecular_function cellular_component cognition uc012fmu.1 uc012fmu.2 uc012fmu.3 
ENSMUST00000121785.9 Palld ENSMUST00000121785.9 palladin, cytoskeletal associated protein, transcript variant 1 (from RefSeq NM_001293772.2) A0JNZ3 ENSMUST00000121785.1 ENSMUST00000121785.2 ENSMUST00000121785.3 ENSMUST00000121785.4 ENSMUST00000121785.5 ENSMUST00000121785.6 ENSMUST00000121785.7 ENSMUST00000121785.8 Kiaa0992 NM_001293772 PALLD_MOUSE Q69ZT7 Q6DFX7 Q9CWW1 Q9ET54 uc009luf.1 uc009luf.2 uc009luf.3 uc009luf.4 uc009luf.5 Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular locations. May be required for the initiation of neural tube closure. Interacts with EPS8 (PubMed:16868024). Interacts with LASP1 (PubMed:16492705). Interacts with VASP (PubMed:14983521). Interacts with ACTN (By similarity). Interacts with SORBS2 (By similarity). Interacts with PFN1 (By similarity). Interacts with LPP (By similarity). Interacts with SPIN90 (By similarity). Interacts with SRC (By similarity). Interacts with EZR (By similarity). Interacts with RAI14 (By similarity). Cytoplasm, cytoskeleton Cell junction, focal adhesion Cytoplasm, myofibril, sarcomere, Z line Cell projection, ruffle Cell projection, podosome Cell projection, lamellipodium Cell projection, axon Cell projection, growth cone Note=Localizes to stress fibers and Z lines (PubMed:10931874). Preferentially expressed in the excitatory presynaptic terminals (By similarity). Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=200 kDa isoform; IsoId=Q9ET54-1; Sequence=Displayed; Name=2; IsoId=Q9ET54-2; Sequence=VSP_027934, VSP_027935, VSP_027936; Name=3; Synonyms=90 kDa isoform, 3Ig isoform; IsoId=Q9ET54-3; Sequence=VSP_027932, VSP_027935; Name=4; Synonyms=140 kDa isoform, 4Ig isoform; IsoId=Q9ET54-4; Sequence=VSP_027933, VSP_027935; Name=5; IsoId=Q9ET54-5; Sequence=VSP_027931; Name=6; IsoId=Q9ET54-6; Sequence=VSP_027935; Detected in both muscle and non-muscle tissues and cells (at protein level). Isoform 3 is widely expressed, isoform 4 is particularly abundant in tissues rich in smooth muscle and in the cardiac muscle and isoform 1 is detected in heart. Ubiquitously detected in embryonic tissues, and down-regulated in certain adult tissues (at protein level). Isoform 3 is widely expressed in embryonic tissues (at protein level). In adults is detected in spleen and gut, and is almost undetectable in heart, skeletal muscle, liver, and kidney (at protein level). Isoform 4 is widely expressed in neonatal tissues (brain, heart, lung, stomach, intestine, kidney, bone and skin) (at protein level). Late in development expression is restricted to cardiac muscle and to organs rich in smooth muscle (at protein level). Isoform 1 is detected in neonatal striated muscle and bone, and remains highly expressed in adult skeletal and cardiac muscle (at protein level). Adult brain express an isoform of 80-85 kDa. At 8.5 dpc is mainly expressed the rostral and caudal part of neural plate. No expression is detected in somite. At 9.5 dpc and 10.5 dpc is ubiquitously detected. Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines. Phosphorylation at Ser-1143 by PKB/AKT1 modulates cytoskeletal organization and cell motility (By similarity). Death around 15.5 dpc due to severe neural tube closure defects and herniation of liver and intestine. Palld-deficient mouse embryonic fibroblasts display disorganized actin cytoskeleton, decreased polymerized filament actin, and decreased cell adhesion and compromised cell spreading on various extracellular matrix. Mice embryos lacking Palld exhibit defects in erythropoiesis. Belongs to the myotilin/palladin family. Sequence=AK031696; Type=Frameshift; Evidence=; Sequence=BAB26871.1; Type=Erroneous initiation; Evidence=; stress fiber ruffle podosome keratinocyte development epithelial cell morphogenesis actin binding nucleus cytoplasm cytosol cytoskeleton actin filament plasma membrane focal adhesion homophilic cell adhesion via plasma membrane adhesion molecules axon guidance axon guidance receptor activity cytoskeletal protein binding actin cytoskeleton cell migration Z disc lamellipodium actin cytoskeleton organization cell junction filopodium axon growth cone neuron projection development ruffle organization cell projection neuronal cell body axonal growth cone synapse organization positive regulation of podosome assembly uc009luf.1 uc009luf.2 uc009luf.3 uc009luf.4 uc009luf.5 
ENSMUST00000121793.2 Oosp2 ENSMUST00000121793.2 oocyte secreted protein 2 (from RefSeq NM_001037634.3) ENSMUST00000121793.1 Gm99 NM_001037634 OOSP2_MOUSE Plac1l Q3UPM7 Q4FZG8 Tmem122 uc008gss.1 uc008gss.2 uc008gss.3 Secreted Expressed in ovaries. Highly expressed in the germinal vesicles oocytes and metaphase II oocytes. Deficient mice are viable, with no overt abnormalities. Female mice are fertile. Triple-gene deletion of OOSP1-3 in mice retains fertility but causes significantly lower blastocyst and reduced offspring number. Belongs to the PLAC1 family. Unlike human OOSP2, mouse OOSP2 seems not participate in folliculogenesis and oocyte maturation. Sequence=AAH99498.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component extracellular region biological_process uc008gss.1 uc008gss.2 uc008gss.3 
ENSMUST00000121799.8 Arhgap23 ENSMUST00000121799.8 Arhgap23 (from geneSymbol) Arhgap23 B1AQY2 B1AQY2_MOUSE ENSMUST00000121799.1 ENSMUST00000121799.2 ENSMUST00000121799.3 ENSMUST00000121799.4 ENSMUST00000121799.5 ENSMUST00000121799.6 ENSMUST00000121799.7 NM_001428751 uc007leb.1 uc007leb.2 uc007leb.3 GTPase activator activity signal transduction positive regulation of GTPase activity uc007leb.1 uc007leb.2 uc007leb.3 
ENSMUST00000121820.9 Spock2 ENSMUST00000121820.9 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 (from RefSeq NM_052994.2) ENSMUST00000121820.1 ENSMUST00000121820.2 ENSMUST00000121820.3 ENSMUST00000121820.4 ENSMUST00000121820.5 ENSMUST00000121820.6 ENSMUST00000121820.7 ENSMUST00000121820.8 NM_052994 Q9ER58 TICN2_MOUSE Ticn2 uc007fel.1 uc007fel.2 uc007fel.3 uc007fel.4 May participate in diverse steps of neurogenesis. Binds calcium (By similarity). Secreted, extracellular space, extracellular matrix Brain specific. O-glycosylated; contains chondroitin sulfate and heparan sulfate. calcium ion binding collagen binding glycosaminoglycan binding extracellular region extracellular space positive regulation of cell-substrate adhesion peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan extracellular matrix structural constituent conferring compression resistance extracellular matrix organization extracellular matrix binding cellular response to leukemia inhibitory factor uc007fel.1 uc007fel.2 uc007fel.3 uc007fel.4 
ENSMUST00000121862.3 Ascl2 ENSMUST00000121862.3 Ascl2 (from geneSymbol) Ascl2 D3Z7Q6 D3Z7Q6_MOUSE ENSMUST00000121862.1 ENSMUST00000121862.2 LF202783 uc291xkz.1 uc291xkz.2 DNA binding regulation of transcription from RNA polymerase II promoter protein dimerization activity uc291xkz.1 uc291xkz.2 
ENSMUST00000121869.8 Dzip3 ENSMUST00000121869.8 DAZ interacting protein 3, zinc finger, transcript variant 3 (from RefSeq NM_001356425.1) Dzip3 E9QNZ2 E9QNZ2_MOUSE ENSMUST00000121869.1 ENSMUST00000121869.2 ENSMUST00000121869.3 ENSMUST00000121869.4 ENSMUST00000121869.5 ENSMUST00000121869.6 ENSMUST00000121869.7 NM_001356425 uc007zka.1 uc007zka.2 uc007zka.3 uc007zka.4 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Cytoplasm protein polyubiquitination RNA binding ubiquitin-protein transferase activity cytoplasm phosphatase binding polyubiquitin binding ubiquitin protein ligase activity uc007zka.1 uc007zka.2 uc007zka.3 uc007zka.4 
ENSMUST00000121872.3 C1qtnf7 ENSMUST00000121872.3 C1q and tumor necrosis factor related protein 7, transcript variant 2 (from RefSeq NM_175425.4) C1QT7_MOUSE Ctrp7 ENSMUST00000121872.1 ENSMUST00000121872.2 NM_175425 Q8BVD7 Q8CHX9 uc008xho.1 uc008xho.2 uc008xho.3 uc008xho.4 Secreted protein binding extracellular region collagen trimer extracellular space identical protein binding uc008xho.1 uc008xho.2 uc008xho.3 uc008xho.4 
ENSMUST00000121886.8 Zfp868 ENSMUST00000121886.8 zinc finger protein 868, transcript variant 1 (from RefSeq NM_172754.3) AI449175 ENSMUST00000121886.1 ENSMUST00000121886.2 ENSMUST00000121886.3 ENSMUST00000121886.4 ENSMUST00000121886.5 ENSMUST00000121886.6 ENSMUST00000121886.7 NM_172754 Q3UTQ6 Q3UTQ6_MOUSE Zfp868 uc009lxh.1 uc009lxh.2 uc009lxh.3 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc009lxh.1 uc009lxh.2 uc009lxh.3 
ENSMUST00000121900.8 Gm2012 ENSMUST00000121900.8 Belongs to the XLR/SYCP3 family. (from UniProt B1B0R1) B1B0R1 B1B0R1_MOUSE ENSMUST00000121900.1 ENSMUST00000121900.2 ENSMUST00000121900.3 ENSMUST00000121900.4 ENSMUST00000121900.5 ENSMUST00000121900.6 ENSMUST00000121900.7 Gm2012 uc292noa.1 uc292noa.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc292noa.1 uc292noa.2 
ENSMUST00000121912.2 Defb28 ENSMUST00000121912.2 defensin beta 28 (from RefSeq NM_001037502.2) Defb28 ENSMUST00000121912.1 NM_001037502 OTTMUSG00000015852 Q3V2L0 Q3V2L0_MOUSE uc008nfp.1 uc008nfp.2 Has antibacterial activity. Secreted Belongs to the beta-defensin family. molecular_function extracellular region defense response defense response to bacterium innate immune response uc008nfp.1 uc008nfp.2 
ENSMUST00000121914.3 Or5ap2b-ps1 ENSMUST00000121914.3 Or5ap2b-ps1 (from geneSymbol) ENSMUST00000121914.1 ENSMUST00000121914.2 NR_190803 uc289xpu.1 uc289xpu.2 uc289xpu.1 uc289xpu.2 
ENSMUST00000121925.8 Slc12a8 ENSMUST00000121925.8 solute carrier family 12 (potassium/chloride transporters), member 8, transcript variant 3 (from RefSeq NM_001370999.1) Ccc9 ENSMUST00000121925.1 ENSMUST00000121925.2 ENSMUST00000121925.3 ENSMUST00000121925.4 ENSMUST00000121925.5 ENSMUST00000121925.6 ENSMUST00000121925.7 NM_001370999 Q3TNQ9 Q8K0M9 Q8VI23 S12A8_MOUSE uc289egm.1 uc289egm.2 Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8VI23-1; Sequence=Displayed; Name=2; IsoId=Q8VI23-2; Sequence=VSP_028335; Name=3; IsoId=Q8VI23-3; Sequence=VSP_028334, VSP_028336; Name=4; IsoId=Q8VI23-4; Sequence=VSP_028333, VSP_028336; Belongs to the SLC12A transporter family. cell ion transport potassium ion transport cell volume homeostasis symporter activity potassium:chloride symporter activity membrane integral component of membrane chloride ion homeostasis potassium ion homeostasis transmembrane transport chloride transmembrane transport potassium ion import across plasma membrane uc289egm.1 uc289egm.2 
ENSMUST00000121927.8 Nrip1 ENSMUST00000121927.8 nuclear receptor interacting protein 1, transcript variant 2 (from RefSeq NM_001358238.1) ENSMUST00000121927.1 ENSMUST00000121927.2 ENSMUST00000121927.3 ENSMUST00000121927.4 ENSMUST00000121927.5 ENSMUST00000121927.6 ENSMUST00000121927.7 NM_001358238 NRIP1_MOUSE Nrip1 Q3U166 Q8C3Y8 Q8CBD1 Q9Z2K2 uc007zry.1 uc007zry.2 uc007zry.3 Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (PubMed:11100122). Plays a role in renal development (PubMed:28381549). Interacts with CTBP1, CTBP2, ERS1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH (By similarity). Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1. Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with ZNF366 (By similarity). Interacts with RORA. Q8CBD1; Q505F1: Nr2c1; NbExp=3; IntAct=EBI-1771626, EBI-15617004; Q8CBD1; O15379: HDAC3; Xeno; NbExp=2; IntAct=EBI-1771626, EBI-607682; Nucleus Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed moderately in the skeletal muscle. Expressed at a low level in the adult spleen, liver and brown adipose tissue. Expressed in the ovary at a high level in granulosa cells and at a lower level in the thecal and interstitial compartments. Contains at least 4 autonomous repression domains (RD1-4). Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The Ligand-dependent nuclear receptor binding region is required for ligand-dependent interaction with RAAR and RXRB homo- and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB. Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH (By similarity). Acetylation regulates its nuclear translocation and corepressive activity. Mice are viable and morphologically normal, but smaller than wild-type and heterozygous littermates. Homozygous NRIP1- null mature female are defective in ovulation and completely infertile (PubMed:11100122). Embryos with heterozygous NRIP1 loss show anomalies of the urinary tract including dysplastic kidneys with cystic dilations, severe hydoureter with hydronephrosis and ureterocele (PubMed:28381549). histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding ovarian follicle rupture transcription cofactor activity transcription coactivator activity transcription corepressor activity receptor binding protein binding nucleus nucleolus regulation of transcription from RNA polymerase II promoter circadian rhythm nuclear speck lipid storage estrogen receptor binding ovulation circadian regulation of gene expression nuclear hormone receptor binding glucocorticoid receptor binding histone deacetylase binding retinoic acid receptor binding positive regulation of transcription from RNA polymerase II promoter retinoid X receptor binding rhythmic process cellular response to estradiol stimulus uc007zry.1 uc007zry.2 uc007zry.3 
ENSMUST00000121963.3 Col6a4 ENSMUST00000121963.3 collagen, type VI, alpha 4 (from RefSeq NM_026763.3) A2AX52 A2AX53 A2AX54 A9CR35 CO6A4_MOUSE Dvwa ENSMUST00000121963.1 ENSMUST00000121963.2 NM_026763 uc012gzq.1 uc012gzq.2 uc012gzq.3 Collagen VI acts as a cell-binding protein. Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha- 6(VI). Secreted, extracellular space, extracellular matrix In newborn, it is expressed in lung, kidney, brain, intestine, skin, sternum and, at weak level, calvaria. In adult, it is almost absent with some weak expression in ovary and very weak expression in spleen, lung, uterus and brain. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Belongs to the type VI collagen family. collagen binding extracellular region collagen trimer cell adhesion extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix macromolecular complex uc012gzq.1 uc012gzq.2 uc012gzq.3 
ENSMUST00000121964.8 Cfap251 ENSMUST00000121964.8 cilia and flagella associated protein 251 (from RefSeq NM_001370840.1) CF251_MOUSE Cfap251 E9Q743 ENSMUST00000121964.1 ENSMUST00000121964.2 ENSMUST00000121964.3 ENSMUST00000121964.4 ENSMUST00000121964.5 ENSMUST00000121964.6 ENSMUST00000121964.7 NM_001370840 Q8BMR0 Q9D3X6 Wdr66 uc290zos.1 uc290zos.2 Involved in spermatozoa motility (By similarity). May also regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity). Cytoplasm, cytoskeleton, cilium axoneme Cell projection, cilium, flagellum Sequence=BAB30526.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC26877.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cytoplasm cytoskeleton cilium flagellated sperm motility motile cilium sperm flagellum cell projection uc290zos.1 uc290zos.2 
ENSMUST00000121979.8 Cep135 ENSMUST00000121979.8 centrosomal protein 135 (from RefSeq NM_199032.4) CP135_MOUSE Cep4 ENSMUST00000121979.1 ENSMUST00000121979.2 ENSMUST00000121979.3 ENSMUST00000121979.4 ENSMUST00000121979.5 ENSMUST00000121979.6 ENSMUST00000121979.7 Kiaa0635 NM_199032 Q6A030 Q6P5D4 uc008xvc.1 uc008xvc.2 uc008xvc.3 Centrosomal microtubule-binding protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity). Homodimer (By similarity). Interacts with CEP250 (By similarity). Interacts with DCTN2. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles. Coiled-coil domains are critical for microtubule binding via the formation of a two-stranded coiled-coil structure in homodimers. Belongs to the CEP135/TSGA10 family. cytoplasm centrosome centriole cytoskeleton centriole replication protein C-terminus binding centriole-centriole cohesion positive regulation of non-motile cilium assembly positive regulation of establishment of protein localization uc008xvc.1 uc008xvc.2 uc008xvc.3 
ENSMUST00000121982.3 Gm14332 ENSMUST00000121982.3 Gm14332 (from geneSymbol) ENSMUST00000121982.1 ENSMUST00000121982.2 uc292muh.1 uc292muh.2 uc292muh.3 uc292muh.1 uc292muh.2 uc292muh.3 
ENSMUST00000121992.2 Ido2 ENSMUST00000121992.2 indoleamine 2,3-dioxygenase 2 (from RefSeq NM_145949.2) A4UHF3 E9QKA9 ENSMUST00000121992.1 I23O2_MOUSE Ido2 Indol1 NM_145949 Q8R0V5 uc009lez.1 uc009lez.2 uc009lez.3 uc009lez.4 Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism (PubMed:17499941, PubMed:17499941). Involved in immune regulation (PubMed:25477879). Reaction=L-tryptophan + O2 = N-formyl-L-kynurenine; Xref=Rhea:RHEA:24536, ChEBI:CHEBI:15379, ChEBI:CHEBI:57912, ChEBI:CHEBI:58629; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Note=Binds 1 heme group per subunit. ; Activity is inhibited by D-1MT (1-methyl-D- tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan) but not L- 1MT (1-methyl-L-tryptophan). Kinetic parameters: KM=38.85 mM for L-tryptophan ; Note=Do not accept D-tryptophan as substrate.; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. Expressed mainly in antigen-presenting immune cells, liver, kidney, brain, and placenta (PubMed:25691885, PubMed:17671174). Highly expressed in kidney, followed by epididymis and liver (at protein level) (PubMed:17499941). Detected in the tails of the spermatozoa in the testis and in the kidney tubules (at protein level) (PubMed:17499941). Constitutively expressed in brain. Knockout mice have no apparent defects in embryonic development or hematopoietic differentiation and have wild- type profiles for kynurenine in blood serum and for immune cells in spleen, lymph nodes, peritoneum, thymus and bone marrow. Knockout mice exhibit defects in IDO-mediated T-cell regulation and inflammatory responses (PubMed:25691885). They exhibit defects in allergic or autoimmune responses (PubMed:24402311). Ido1 and Ido2 are 2 distinct enzymes which catalyze the same reaction. Ido2 Km for tryptophan is much higher than that of Ido1. Ido2 may play a role as a negative regulator of Ido1 by competing for heme-binding with Ido1. Low efficiency Ido2 enzymes have been conserved throughout vertebrate evolution, whereas higher efficiency Ido1 enzymes are dispensable in many lower vertebrate lineages. Ido1 may have arisen by gene duplication of a more ancient proto-IDO gene before the divergence of marsupial and eutherian (placental) mammals. Belongs to the indoleamine 2,3-dioxygenase family. Sequence=AAH26393.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; immune system process tryptophan 2,3-dioxygenase activity cytoplasm tryptophan catabolic process oxidoreductase activity tryptophan catabolic process to kynurenine heme binding indoleamine 2,3-dioxygenase activity 'de novo' NAD biosynthetic process from tryptophan metal ion binding dioxygenase activity oxidation-reduction process uc009lez.1 uc009lez.2 uc009lez.3 uc009lez.4 
ENSMUST00000121995.2 Gm15821 ENSMUST00000121995.2 Gm15821 (from geneSymbol) AK007825 ENSMUST00000121995.1 uc289kcn.1 uc289kcn.2 uc289kcn.1 uc289kcn.2 
ENSMUST00000122010.8 Anapc7 ENSMUST00000122010.8 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC7 is not required for the assembly of the APC/C complex, but has an enzyme-substrate adapter activity mediating the processive ubiquitination of specific substrates (By similarity). Involved in brain development through the specific ubiquitination and clearance of MKI67 from constitutive heterochromatin after neuronal progenitors exit mitosis (PubMed:34942119). (from UniProt Q9WVM3) AK030775 APC7_MOUSE Apc7 ENSMUST00000122010.1 ENSMUST00000122010.2 ENSMUST00000122010.3 ENSMUST00000122010.4 ENSMUST00000122010.5 ENSMUST00000122010.6 ENSMUST00000122010.7 Q3UBM7 Q8BSR2 Q91W13 Q9WVM3 uc290zkl.1 uc290zkl.2 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC7 is not required for the assembly of the APC/C complex, but has an enzyme-substrate adapter activity mediating the processive ubiquitination of specific substrates (By similarity). Involved in brain development through the specific ubiquitination and clearance of MKI67 from constitutive heterochromatin after neuronal progenitors exit mitosis (PubMed:34942119). Protein modification; protein ubiquitination. V-shaped homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. Cytoplasm, cytoskeleton Nucleus Cytoplasm, cytoskeleton, spindle Note=Localizes to spindle during metaphase and to cytoplasmic microtubules during interphase. Mice lacking Anapc7 show growth delay around weaning, although birth weight and adult size are normal. They show sensorimotor dysfunction in locomotive assays, as well as defects in the regulation of short- and long-term memory retrieval of the contextual fear response. Loss of the protein does not alter the anatomy of brain regions. Belongs to the APC7 family. nucleus anaphase-promoting complex cell cycle protein ubiquitination protein phosphatase binding cell division protein K11-linked ubiquitination uc290zkl.1 uc290zkl.2 
ENSMUST00000122025.9 Gm15056 ENSMUST00000122025.9 predicted gene 15056 (from RefSeq NM_001177471.2) E9Q8Z3 E9Q8Z3_MOUSE ENSMUST00000122025.1 ENSMUST00000122025.2 ENSMUST00000122025.3 ENSMUST00000122025.4 ENSMUST00000122025.5 ENSMUST00000122025.6 ENSMUST00000122025.7 ENSMUST00000122025.8 Gm15056 NM_001177471 uc291ypm.1 uc291ypm.2 uc291ypm.1 uc291ypm.2 
ENSMUST00000122026.6 Lias ENSMUST00000122026.6 lipoic acid synthetase, transcript variant 1 (from RefSeq NM_024471.5) ENSMUST00000122026.1 ENSMUST00000122026.2 ENSMUST00000122026.3 ENSMUST00000122026.4 ENSMUST00000122026.5 LIAS_MOUSE Lip1 NM_024471 Q543M1 Q99M04 uc008xnq.1 uc008xnq.2 uc008xnq.3 uc008xnq.4 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. Reaction=[[Fe-S] cluster scaffold protein carrying a second [4Fe- 4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'- deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + N(6)-[(R)-dihydrolipoyl]-L-lysyl- [protein] + 2 reduced [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:16585, Rhea:RHEA-COMP:9928, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001, Rhea:RHEA-COMP:10475, Rhea:RHEA-COMP:14568, Rhea:RHEA-COMP:14569, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319, ChEBI:CHEBI:29034, ChEBI:CHEBI:29919, ChEBI:CHEBI:33722, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:78809, ChEBI:CHEBI:83100; EC=2.8.1.8; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. ; Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier- protein]: step 2/2. Mitochondrion Expressed predominantly in heart, testis, and liver. Belongs to the radical SAM superfamily. Lipoyl synthase family. neural tube closure catalytic activity cytoplasm mitochondrion inflammatory response response to oxidative stress lipoate biosynthetic process protein lipoylation transferase activity sulfurtransferase activity lipoate synthase activity response to lipopolysaccharide metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding uc008xnq.1 uc008xnq.2 uc008xnq.3 uc008xnq.4 
ENSMUST00000122050.2 H2ab3 ENSMUST00000122050.2 H2A.B variant histone 3 (from RefSeq NM_001281531.2) ENSMUST00000122050.1 H2ab3 NM_001281531 S4R1G7 S4R1G7_MOUSE uc033jsi.1 uc033jsi.2 uc033jsi.3 uc033jsi.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. CCDS Note: There are no publicly available full-length transcripts representing this CCDS in mouse. The CDS structure is based on the alignment of paralogous histone H2afb transcripts (BC061062.1). ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 25731851 ##RefSeq-Attributes-END## The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2A family. nucleosome nuclear nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization transcriptionally active chromatin protein heterodimerization activity uc033jsi.1 uc033jsi.2 uc033jsi.3 uc033jsi.4 
ENSMUST00000122054.8 Fgfr2 ENSMUST00000122054.8 fibroblast growth factor receptor 2, transcript variant 1 (from RefSeq NM_010207.2) E9QK53 E9QK53_MOUSE ENSMUST00000122054.1 ENSMUST00000122054.2 ENSMUST00000122054.3 ENSMUST00000122054.4 ENSMUST00000122054.5 ENSMUST00000122054.6 ENSMUST00000122054.7 Fgfr2 NM_010207 uc033jcj.1 uc033jcj.2 uc033jcj.3 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence= Cell membrane ; Single-pass type I membrane protein Cytoplasmic vesicle Golgi apparatus Membrane ; Single-pass type I membrane protein Vesicle Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. nucleotide binding epithelial to mesenchymal transition endochondral bone growth protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor-activated receptor activity ATP binding nucleus nucleoplasm cytoplasm integral component of plasma membrane cell cortex protein phosphorylation positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway cell surface positive regulation of phospholipase activity membrane integral component of membrane kinase activity phosphorylation transferase activity fibroblast growth factor binding peptidyl-tyrosine phosphorylation response to lipopolysaccharide wound healing protein homodimerization activity intracellular membrane-bounded organelle positive regulation of MAPK cascade cellular response to fibroblast growth factor stimulus response to ethanol protein autophosphorylation mesodermal cell differentiation positive regulation of smooth muscle cell proliferation embryonic cranial skeleton morphogenesis negative regulation of epithelial cell proliferation cellular response to retinoic acid cellular response to transforming growth factor beta stimulus uc033jcj.1 uc033jcj.2 uc033jcj.3 
ENSMUST00000122063.8 Ift88 ENSMUST00000122063.8 intraflagellar transport 88, transcript variant 1 (from RefSeq NM_009376.3) ENSMUST00000122063.1 ENSMUST00000122063.2 ENSMUST00000122063.3 ENSMUST00000122063.4 ENSMUST00000122063.5 ENSMUST00000122063.6 ENSMUST00000122063.7 G3X9Z7 G3X9Z7_MOUSE Ift88 NM_009376 uc007udb.1 uc007udb.2 uc007udb.3 uc007udb.4 centrosome centriole cilium motile cilium ciliary basal body uc007udb.1 uc007udb.2 uc007udb.3 uc007udb.4 
ENSMUST00000122064.8 Emcn ENSMUST00000122064.8 endomucin, transcript variant 1 (from RefSeq NM_001163522.1) ENSMUST00000122064.1 ENSMUST00000122064.2 ENSMUST00000122064.3 ENSMUST00000122064.4 ENSMUST00000122064.5 ENSMUST00000122064.6 ENSMUST00000122064.7 MUCEN_MOUSE Muc14 NM_001163522 Q78KL2 Q9DCN9 Q9R0H2 Q9ULC1 Q9Z2I1 uc008rml.1 uc008rml.2 uc008rml.3 uc008rml.4 Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=1a; IsoId=Q9R0H2-1; Sequence=Displayed; Name=2; Synonyms=1b; IsoId=Q9R0H2-2; Sequence=VSP_010829; Name=3; Synonyms=1c; IsoId=Q9R0H2-3; Sequence=VSP_010827; Name=4; Synonyms=1d; IsoId=Q9R0H2-4; Sequence=VSP_010828; Highly expressed in heart and kidney, followed by brain, spleen, thymus, liver and lung. Exclusively expressed in endothelial cells. Highly O-glycosylated. Sialic acid-rich glycoprotein. angiogenesis plasma membrane membrane integral component of membrane regulation of cell adhesion carbohydrate binding cell-cell adhesion uc008rml.1 uc008rml.2 uc008rml.3 uc008rml.4 
ENSMUST00000122078.3 Tex55 ENSMUST00000122078.3 testis expressed 55, transcript variant 1 (from RefSeq NM_029042.2) A4QMY3 A6X8Z9 ENSMUST00000122078.1 ENSMUST00000122078.2 NM_029042 Q8C5T0 TEX55_MOUSE Tex55 Tscpa uc007zfn.1 uc007zfn.2 uc007zfn.3 Nucleus Testis-specific. molecular_function nucleus biological_process uc007zfn.1 uc007zfn.2 uc007zfn.3 
ENSMUST00000122088.2 S1pr5 ENSMUST00000122088.2 sphingosine-1-phosphate receptor 5 (from RefSeq NM_053190.2) ENSMUST00000122088.1 Edg8 Lpb4 NM_053190 Q91X56 Q99MN8 S1PR5_MOUSE uc009oks.1 uc009oks.2 uc009oks.3 uc009oks.4 Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway. The S1P-induced survival of mature oligodendrocytes is mediated through a pertussis toxin-sensitive, Akt- dependent pathway. S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. These effects depend on the developmental stage of the cell. Cell membrane; Multi-pass membrane protein. Expressed in spleen and brain. In the CNS expression is restricted to oligodendrocytes. Expressed in 7-day and 17-day embryos, but not in 11-day and 15-day embryos, implying its role in mammalian development. In oligodendrocytes, expressed throughout development from the immature stages to the mature myelin-froming cell. Belongs to the G-protein coupled receptor 1 family. sphingosine-1-phosphate signaling pathway G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane sphingosine-1-phosphate receptor activity regulation of neuron differentiation uc009oks.1 uc009oks.2 uc009oks.3 uc009oks.4 
ENSMUST00000122091.8 Zwilch ENSMUST00000122091.8 zwilch kinetochore protein, transcript variant 3 (from RefSeq NR_176424.1) ENSMUST00000122091.1 ENSMUST00000122091.2 ENSMUST00000122091.3 ENSMUST00000122091.4 ENSMUST00000122091.5 ENSMUST00000122091.6 ENSMUST00000122091.7 NR_176424 Q8R060 Q9D2E4 Q9D761 ZWILC_MOUSE uc009qbm.1 uc009qbm.2 uc009qbm.3 uc009qbm.4 Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity). Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH; in the complex interacts directly with KNTC1/ROD (By similarity). Chromosome, centromere, kinetochore Belongs to the ZWILCH family. chromosome, centromeric region kinetochore condensed chromosome kinetochore molecular_function chromosome cell cycle mitotic cell cycle checkpoint cell division RZZ complex uc009qbm.1 uc009qbm.2 uc009qbm.3 uc009qbm.4 
ENSMUST00000122096.3 Eif4a3l2 ENSMUST00000122096.3 Nucleus speckle (from UniProt A0A0N4SVP8) A0A0N4SVP8 A0A0N4SVP8_MOUSE BC158083 ENSMUST00000122096.1 ENSMUST00000122096.2 Eif4a3l2 uc291idm.1 uc291idm.2 Nucleus speckle Belongs to the DEAD box helicase family. eIF4A subfamily. nucleotide binding nucleic acid binding RNA binding mRNA binding helicase activity ATP binding nucleolus hydrolase activity catalytic step 2 spliceosome uc291idm.1 uc291idm.2 
ENSMUST00000122097.9 Gm14434 ENSMUST00000122097.9 predicted gene 14434 (from RefSeq NM_001101804.1) A2ART4 A2ART4_MOUSE ENSMUST00000122097.1 ENSMUST00000122097.2 ENSMUST00000122097.3 ENSMUST00000122097.4 ENSMUST00000122097.5 ENSMUST00000122097.6 ENSMUST00000122097.7 ENSMUST00000122097.8 Gm11007 Gm14308 Gm14434 Gm2007 Gm2026 Gm4631 Gm4724 NM_001101804 RP23-376N23.4-001 RP24-574J13.1-003 uc290def.1 uc290def.2 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290def.1 uc290def.2 
ENSMUST00000122110.8 Usp5 ENSMUST00000122110.8 ubiquitin specific peptidase 5 (isopeptidase T), transcript variant 9 (from RefSeq NM_001410493.1) ENSMUST00000122110.1 ENSMUST00000122110.2 ENSMUST00000122110.3 ENSMUST00000122110.4 ENSMUST00000122110.5 ENSMUST00000122110.6 ENSMUST00000122110.7 NM_001410493 Q3U4W8 Q3U4W8_MOUSE Usp5 uc009dsb.1 uc009dsb.2 uc009dsb.3 uc009dsb.4 Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence= Belongs to the peptidase C19 family. thiol-dependent ubiquitin-specific protease activity proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity zinc ion binding protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity metal ion binding uc009dsb.1 uc009dsb.2 uc009dsb.3 uc009dsb.4 
ENSMUST00000122120.8 Tafa1 ENSMUST00000122120.8 TAFA chemokine like family member 1 (from RefSeq NM_182808.3) A2RSN6 ENSMUST00000122120.1 ENSMUST00000122120.2 ENSMUST00000122120.3 ENSMUST00000122120.4 ENSMUST00000122120.5 ENSMUST00000122120.6 ENSMUST00000122120.7 Fam19a1 NM_182808 Q7TPG8 TAFA1_MOUSE uc009dae.1 uc009dae.2 uc009dae.3 This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK050001.1, SRR1660815.238130.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Regulatory factor which is ligand for CMKLR2 and is involved in the modulation of neural stem-cell proliferation and differentiation. Secreted Expressed in the hippocampus and detected also in the cortex (at protein level). Detected as early as 12.5 dpc, expression peaks between postnatal day 1 and day 7 and decreases at week 8 after birth (at protein level). Expression decreases upon brain injury. Belongs to the TAFA family. extracellular region extracellular space endoplasmic reticulum signal transduction regulation of receptor activity neuroblast differentiation receptor agonist activity regulation of neuroblast proliferation uc009dae.1 uc009dae.2 uc009dae.3 
ENSMUST00000122148.8 Bahcc1 ENSMUST00000122148.8 BAH domain and coiled-coil containing 1 (from RefSeq NM_001347621.2) A2AS78 BAHC1_MOUSE ENSMUST00000122148.1 ENSMUST00000122148.2 ENSMUST00000122148.3 ENSMUST00000122148.4 ENSMUST00000122148.5 ENSMUST00000122148.6 ENSMUST00000122148.7 Kiaa1447 NM_001347621 Q0KK52 Q0KK57 Q3TPP4 Q3UHG9 Q3UHR0 Q6GQV4 Q6P9S8 Q6PFC9 Q80UX2 uc007msd.1 uc007msd.2 uc007msd.3 uc007msd.4 Sequence=AAH60615.1; Type=Erroneous initiation; Evidence=; Sequence=AAH72602.1; Type=Erroneous initiation; Evidence=; Sequence=BAE27888.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE27888.1; Type=Frameshift; Evidence=; Sequence=BAE37691.1; Type=Erroneous initiation; Evidence=; chromatin binding uc007msd.1 uc007msd.2 uc007msd.3 uc007msd.4 
ENSMUST00000122154.3 Fam236d ENSMUST00000122154.3 Fam236d (from geneSymbol) A0A1B0GSB3 A0A1B0GSB3_MOUSE ENSMUST00000122154.1 ENSMUST00000122154.2 Fam236d Gm3880 uc292puw.1 uc292puw.2 uc292puw.1 uc292puw.2 
ENSMUST00000122199.10 Erg ENSMUST00000122199.10 ETS transcription factor, transcript variant 3 (from RefSeq NM_001302153.1) ENSMUST00000122199.1 ENSMUST00000122199.2 ENSMUST00000122199.3 ENSMUST00000122199.4 ENSMUST00000122199.5 ENSMUST00000122199.6 ENSMUST00000122199.7 ENSMUST00000122199.8 ENSMUST00000122199.9 Erg NM_001302153 Q3UQJ4 Q3UQJ4_MOUSE uc008abz.1 uc008abz.2 uc008abz.3 uc008abz.4 Nucleus Belongs to the ETS family. DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc008abz.1 uc008abz.2 uc008abz.3 uc008abz.4 
ENSMUST00000122204.3 Ppihl ENSMUST00000122204.3 PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. (from UniProt Q9D868) ENSMUST00000122204.1 ENSMUST00000122204.2 LF194942 PPIH_MOUSE Ppih Q9CQU7 Q9D868 uc290vei.1 uc290vei.2 PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Inhibited by cyclosporin A. Interacts directly with PRPF4. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Heterodimer with PRPF18. Heterodimer with PRPF18 (By similarity). Nucleus speckle Cytoplasm Note=Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D868-1; Sequence=Displayed; Name=2; IsoId=Q9D868-2; Sequence=VSP_008325; Belongs to the cyclophilin-type PPIase family. PPIase H subfamily. protein peptidyl-prolyl isomerization angiogenesis peptidyl-prolyl cis-trans isomerase activity nucleus spliceosomal complex cytoplasm mRNA processing protein folding RNA splicing cyclosporin A binding nuclear speck isomerase activity protein refolding ribonucleoprotein complex binding positive regulation of viral genome replication U4/U6 x U5 tri-snRNP complex unfolded protein binding U4/U6 snRNP uc290vei.1 uc290vei.2 
ENSMUST00000122218.10 Gm14408 ENSMUST00000122218.10 Belongs to the krueppel C2H2-type zinc-finger protein family. (from UniProt E9Q6B9) AK164563 E9Q6B9 E9Q6B9_MOUSE ENSMUST00000122218.1 ENSMUST00000122218.2 ENSMUST00000122218.3 ENSMUST00000122218.4 ENSMUST00000122218.5 ENSMUST00000122218.6 ENSMUST00000122218.7 ENSMUST00000122218.8 ENSMUST00000122218.9 Gm14408 uc290dev.1 uc290dev.2 uc290dev.3 Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc290dev.1 uc290dev.2 uc290dev.3 
ENSMUST00000122222.8 Casz1 ENSMUST00000122222.8 castor zinc finger 1, transcript variant 1 (from RefSeq NM_001159344.1) B1AS46 B1AS46_MOUSE Casz1 ENSMUST00000122222.1 ENSMUST00000122222.2 ENSMUST00000122222.3 ENSMUST00000122222.4 ENSMUST00000122222.5 ENSMUST00000122222.6 ENSMUST00000122222.7 NM_001159344 uc008vvn.1 uc008vvn.2 uc008vvn.3 uc008vvn.4 nucleic acid binding regulation of transcription, DNA-templated uc008vvn.1 uc008vvn.2 uc008vvn.3 uc008vvn.4 
ENSMUST00000122229.8 Serpina1e ENSMUST00000122229.8 Does not inhibit elastase or chymotrypsin. No target protease has been identified to date. (from UniProt Q00898) A1AT5_MOUSE AK146576 Dom5 ENSMUST00000122229.1 ENSMUST00000122229.2 ENSMUST00000122229.3 ENSMUST00000122229.4 ENSMUST00000122229.5 ENSMUST00000122229.6 ENSMUST00000122229.7 Q00898 Q3UJ83 Q545P1 Spi1-5 uc288iwn.1 uc288iwn.2 Does not inhibit elastase or chymotrypsin. No target protease has been identified to date. Secreted The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the active site of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity. Murine alpha-1-antitrypsin is represented by a cluster of up to 6 individual Serpina1-related genes. The precise complement of Serpina1-related genes present varies according to the strain of the animal. Belongs to the serpin family. Sequence=BAE27272.1; Type=Erroneous initiation; Evidence=; protease binding endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity extracellular region extracellular space endoplasmic reticulum Golgi apparatus negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to cytokine identical protein binding intracellular membrane-bounded organelle response to peptide hormone uc288iwn.1 uc288iwn.2 
ENSMUST00000122255.8 Crtc3 ENSMUST00000122255.8 CREB regulated transcription coactivator 3 (from RefSeq NM_173863.3) CRTC3_MOUSE ENSMUST00000122255.1 ENSMUST00000122255.2 ENSMUST00000122255.3 ENSMUST00000122255.4 ENSMUST00000122255.5 ENSMUST00000122255.6 ENSMUST00000122255.7 NM_173863 Q91X84 Torc3 uc009iaz.1 uc009iaz.2 uc009iaz.3 Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348, PubMed:30611118). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation (By similarity). Enhances the interaction of CREB1 with TAF4 (By similarity). Regulates the expression of specific CREB- activated genes such as the steroidogenic gene, StAR (By similarity). Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter (By similarity). 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (By similarity). Interacts (when phosphorylated at Ser-162 and Se-273) with 14-3-3 proteins (PubMed:28235073, PubMed:30611118). Interacts with YWHAE (PubMed:30611118). Interacts (when phosphorylated at Ser-391) with phosphatase PP2A catalytic subunit PPP2CA and regulatory subunits PPP2R1A and PPP2R2A (PubMed:30611118). Nucleus Cytoplasm Note=Appears to be mainly nuclear. Translocates to the nucleus following adenylyl cyclase or MAP kinase activation (PubMed:30611118). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91X84-1; Sequence=Displayed; Name=2; IsoId=Q91X84-2; Sequence=VSP_031221; Expressed in brown adipose tissues. Phosphorylation/dephosphorylation states of Ser-273 are required for regulating transduction of CREB activity (PubMed:29211348). CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site (PubMed:29211348). May be phosphorylated at Ser-391 by MAPK3/ERK1 and/or MAPK1/ERK2 or by some cyclin-dependent kinases such as CDK1,CDK2 or CDK5 (PubMed:30611118). Following adenylyl cyclase activation, dephosphorylated at Ser-162 and Ser-273 resulting in its dissociation from 14-3-3 proteins probably promoting CRTC3 translocation into the nucleus (PubMed:30611118). Belongs to the TORC family. protein binding nucleus nucleoplasm cytoplasm cytosol cAMP response element binding protein binding positive regulation of CREB transcription factor activity macrophage activation negative regulation of cAMP-mediated signaling positive regulation of transcription from RNA polymerase II promoter negative regulation of lipid catabolic process protein homotetramerization energy homeostasis uc009iaz.1 uc009iaz.2 uc009iaz.3 
ENSMUST00000122261.8 Tbata ENSMUST00000122261.8 thymus, brain and testes associated, transcript variant 2 (from RefSeq NM_001017419.2) B2ZA64 ENSMUST00000122261.1 ENSMUST00000122261.2 ENSMUST00000122261.3 ENSMUST00000122261.4 ENSMUST00000122261.5 ENSMUST00000122261.6 ENSMUST00000122261.7 NM_001017419 Q6XBG6 Q6XBG7 Q6XBG8 Q7TSD4 Q7TSD5 Q8BYU0 Q9EQE4 Q9EQE5 Spatial TBATA_MOUSE uc007ffo.1 uc007ffo.2 uc007ffo.3 uc007ffo.4 This gene encodes a putative transcription factor that is highly expressed in thymic cortical stromal cells, and may be involved in T-cell development. Its expression is developmentally regulated in the testis, where it is restricted to the haploid round spermatids during spermatogenesis, and thus this gene may also have a role in the control of male germ cell development. Alternative splicing of this gene results in two sets of transcript variants: the variants containing 5 additional exons at the 3' end encode long isoforms that are highly expressed in the testis, while the variants lacking the 3' end exons encode short isoforms that are highly expressed in the thymus. Most of the transcripts encoding the short isoforms have been shown to initiate translation from non-AUG (CUG) start sites. [provided by RefSeq, Jul 2008]. Isoform 1 and isoform 2 may play a role in spermatid differentiation. Isoform 1 and isoform 2 regulate thymus function by modulating stromal cell proliferation via interference with the NEDD8 pathway. Interacts with KIF17. Interacts with UBA3. [Isoform 1]: Cytoplasm, cytosol Note=Located throughout the cytosol of early round spermatids. By the end stages of round spermatid development, concentrated at the side of the cell near the nascent flagellum and in the manchette. In mature sperm, located in the principle piece of the tail. [Isoform 2]: Cytoplasm, cytosol Note=Located throughout the cytosol of early round spermatids. By the end stages of round spermatid development, concentrated at the side of the cell near the nascent flagellum and in the manchette. In mature sperm, located in the principle piece of the tail. [Isoform 6]: Nucleus [Isoform 7]: Nucleus Event=Alternative splicing; Named isoforms=8; Name=1 ; Synonyms=Epsilon ; IsoId=Q7TSD4-1; Sequence=Displayed; Name=2 ; Synonyms=Delta ; IsoId=Q7TSD4-2; Sequence=VSP_052937; Name=3 ; Synonyms=Beta ; IsoId=Q7TSD4-3; Sequence=VSP_052935, VSP_052937, VSP_052940, VSP_052941, VSP_052942; Name=4 ; Synonyms=Alpha ; IsoId=Q7TSD4-4; Sequence=VSP_052935, VSP_052939, VSP_052941, VSP_052942; Name=5 ; Synonyms=Gamma ; IsoId=Q7TSD4-5; Sequence=VSP_052937, VSP_052941, VSP_052942; Name=6 ; IsoId=Q7TSD4-6; Sequence=VSP_052935, VSP_052941, VSP_052942; Name=7 ; IsoId=Q7TSD4-7; Sequence=VSP_052935, VSP_052937, VSP_052941, VSP_052942; Name=8; Synonyms=Zeta; IsoId=Q7TSD4-8; Sequence=VSP_052935, VSP_052936, VSP_052938; Expressed in the subcapsular region of the thymus and lymph node (at protein level). Highly expressed in thymic cortical stromal cells and testis. Lower levels found in brain cortex, hippocampus, kidney, cerebellum, skeletal muscle, epididymis and ovary. No expression detected in other lymphoid organs including bone marrow and spleen. Isoform 1 and isoform 2 are expressed predominantly in testis. Isoform 3, isoform 4 and isoform 5 are expressed predominantly in thymus although isoform 3 is also expressed in testis. In the CNS, highly expressed in restricted areas, the cerebellum and hippocampus. In testis, isoform 1 and isoform 2 are expressed only in the adult from postnatal week 7. Expression is detected in pachytene spermatocytes, increases greatly in round spermatids and is very strong in round/elongating and elongating spermatids. Expression is reduced in condensed spermatids and persists in spermatozoa. Isoform 3 is specifically expressed in round spermatids and is greatly reduced in spermatids under maturation (at protein level). Isoform 7 is detected in the embryo from day 10 while isoform 7 is not detected until day 12. In brain, predominantly expressed by granule cells during cerebellar development. Isoform 1 and isoform 3 are differentially expressed during cerebellar development. Up-regulated in aged mice (4 months of age or older). Belongs to the TBATA family. Sequence=AAP41211.1; Type=Frameshift; Evidence=; Sequence=AAP50907.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAP50908.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding nucleus cytoplasm cytosol multicellular organism development spermatogenesis cell differentiation spermatid differentiation uc007ffo.1 uc007ffo.2 uc007ffo.3 uc007ffo.4 
ENSMUST00000122328.8 Pxdn ENSMUST00000122328.8 peroxidasin (from RefSeq NM_181395.2) A4FU83 E9QNQ9 ENSMUST00000122328.1 ENSMUST00000122328.2 ENSMUST00000122328.3 ENSMUST00000122328.4 ENSMUST00000122328.5 ENSMUST00000122328.6 ENSMUST00000122328.7 Kiaa0230 NM_181395 PXDN_MOUSE Pxdn Q3UQ28 uc007ngl.1 uc007ngl.2 uc007ngl.3 Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer (PubMed:31817535, PubMed:22842973, PubMed:29626421, PubMed:25708780, PubMed:28424209). In turns, directly contributes to the collagen IV network-dependent fibronectin/FN and laminin assembly, which is required for full extracellular matrix (ECM)-mediated signaling (By similarity). Thus, sulfilimine cross-links are essential for growth factor-induced cell proliferation and survival in endothelial cells, an event essential to basement membrane integrity (By similarity). In addition, through the bromide oxidation, may promote tubulogenesis and induce angiogenesis through ERK1/2, Akt, and FAK pathways (By similarity). Moreover brominates alpha2 collagen IV chain/COL4A2 at 'Tyr-1480' and leads to bromine enrichment of the basement membranes (PubMed:32675287, PubMed:32571911). In vitro, can also catalyze the two-electron oxidation of thiocyanate and iodide and these two substrates could effectively compete with bromide and thus inhibit the formation of sulfilimine bonds (By similarity). Binds laminins (By similarity). May play a role in the organization of eyeball structure and lens development during eye development (PubMed:31817535, PubMed:24895407). Reaction=H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O; Xref=Rhea:RHEA:66020, Rhea:RHEA-COMP:12751, Rhea:RHEA-COMP:16949, Rhea:RHEA-COMP:16951, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16044, ChEBI:CHEBI:16240, ChEBI:CHEBI:29969, ChEBI:CHEBI:166867; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66021; Evidence= Reaction=bromide + H2O2 = H2O + hypobromite; Xref=Rhea:RHEA:66016, ChEBI:CHEBI:15377, ChEBI:CHEBI:15858, ChEBI:CHEBI:16240, ChEBI:CHEBI:29250; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66017; Evidence= Reaction=hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O; Xref=Rhea:RHEA:66024, Rhea:RHEA-COMP:12751, Rhea:RHEA-COMP:16949, Rhea:RHEA-COMP:16951, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15858, ChEBI:CHEBI:16044, ChEBI:CHEBI:29250, ChEBI:CHEBI:29969, ChEBI:CHEBI:166867; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66025; Evidence= Reaction=(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl- [collagen] = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl- [collagen] + bromide + H(+) + H2O; Xref=Rhea:RHEA:66012, Rhea:RHEA- COMP:12752, Rhea:RHEA-COMP:16949, Rhea:RHEA-COMP:16950, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15858, ChEBI:CHEBI:16044, ChEBI:CHEBI:29250, ChEBI:CHEBI:133442, ChEBI:CHEBI:166866; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66013; Evidence=; Reaction=(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl- [collagen] = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl- [collagen] + H(+) + 2 H2O; Xref=Rhea:RHEA:66008, Rhea:RHEA- COMP:12752, Rhea:RHEA-COMP:16949, Rhea:RHEA-COMP:16950, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16044, ChEBI:CHEBI:16240, ChEBI:CHEBI:133442, ChEBI:CHEBI:166866; Evidence=; Reaction=bromide + H(+) + H2O2 + L-tyrosyl-[protein] = 3-bromo-L- tyrosyl-[protein] + 2 H2O; Xref=Rhea:RHEA:69360, Rhea:RHEA- COMP:10136, Rhea:RHEA-COMP:17686, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15858, ChEBI:CHEBI:16240, ChEBI:CHEBI:46858, ChEBI:CHEBI:183512; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69361; Evidence=; Reaction=H(+) + hypobromite + L-tyrosyl-[protein] = 3-bromo-L-tyrosyl- [protein] + H2O; Xref=Rhea:RHEA:69356, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:17686, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29250, ChEBI:CHEBI:46858, ChEBI:CHEBI:183512; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69357; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per subunit. ; Thiocyanate inhibits the formation of 3- bromotyrosine. Homotrimer; disulfide-linked. The homotrimer form is predominant. Homooligomer; disulfide-linked. Oligomerization occurs intracellularly before C-terminal proteolytic cleavage (By similarity). Interacts with PXDNL; this interaction inhibits the peroxidase activity of PXDN (By similarity). Secreted, extracellular space, extracellular matrix Endoplasmic reticulum Cell surface Secreted, extracellular space, extracellular matrix, basement membrane Note=Adheres on the cell surface in 'hot spots'. [PXDN active fragment]: Secreted, extracellular space, extracellular matrix Highly expressed in the cardiovascular system. In the embryo, expressed in the corneal epithelial layer. In the adult eyes, expressed in the corneal and lens epithelium. Expressed in lung (PubMed:31817535). Expressed in all embryonic tissues at 10 dpc. Detected at 7 dpc (PubMed:18848646, PubMed:18929642). At 11.5 dpc, faintly expressed in the lens epithelium cells and in the anterior part of primary fiber cells. At 13.5 dpc, strongly expressed in the developing lens especially the lens epithelium cells and in the inner limiting membrane. Additionally, it is also expressed in ocular mesenchymal cells in the vitreous. At 17.5 dpc, expressed not only in the whole lens, but also in the inner neuroblast layer. In the lens, appears to be strongly expressed in the lens epithelial and at the posterior pole of the lens (PubMed:18929642). The VWFC domain mediates the covalent links between monomers throught disulfide bridges. Ig-like C2-type domains are required to sulfilimine bond formation. The VWFC domain is not required for trimerization. The LRR domain mediates high affinity binding to laminin-1. Processed by FURIN and the proteolytic processing largely depends on the peroxidase activity of PXDN (PubMed:34679700). The proteolytic cleavage occurs after intracellular homotrimerization and releases into the extracellular matrix a large, catalytically active fragment and a smaller fragment consisting primarily of the C-terminal VWFC domain. The processing enhances both peroxidase activity and sulfilimine cross- links formation (By similarity). Homozygous mice for the PXDN gene show completely or almost closed eyelids with small eyes, having no apparent external morphological defects in other organs (PubMed:31817535). In addition, mice show hair color change and the tail color is white and also have a white spot at the ventral and dorsal region at a frequency of about 94.1%. Some of mutants have severe cataracts in the eyes (PubMed:31817535). Belongs to the peroxidase family. XPO subfamily. peroxidase activity extracellular matrix structural constituent extracellular region extracellular space endoplasmic reticulum response to oxidative stress oxidoreductase activity bromide peroxidase activity heme binding extracellular matrix organization collagen fibril organization hydrogen peroxide catabolic process metal ion binding oxidation-reduction process cellular oxidant detoxification uc007ngl.1 uc007ngl.2 uc007ngl.3 
ENSMUST00000122333.2 Klhl14 ENSMUST00000122333.2 kelch-like 14 (from RefSeq NM_001081403.2) ENSMUST00000122333.1 KLH14_MOUSE Kiaa1384 NM_001081403 Q69ZK5 Q9CU51 uc289ohn.1 uc289ohn.2 Interacts with TOR1A. Cytoplasm, cytosol Endoplasmic reticulum membrane Note=In neurons, located in cell bodies, as well as in neurites. Expressed in the brain, primarily in neurons. In the cerebral cortex, mostly expressed in layers I and II (at protein level). Also observed in some neurons of the corpus striatum (at protein level). Expressed at high levels in the hippocampus, including in pyramidal cells of the CA1 and CA3 layers (at protein level). In the cerebellum, expression in Purkinje cells is higher than in granular cells (at protein level). Also detected in the medial septum, ventral pallidum, thalamus, hypothalamus, amygdala, inferior colliculi, locus caeruleus, peripyramidal nucleus, raphe nucleus, reticular formation, spinal trigeminal nucleus, and vestibular nuclei (at protein level). Low expression, if any, in glial cells (at protein level). Not observed in the corpus callosum. protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol actin cytoskeleton membrane aggresome neuron projection neuronal cell body uc289ohn.1 uc289ohn.2 
ENSMUST00000122358.8 Tm9sf1 ENSMUST00000122358.8 transmembrane 9 superfamily member 1, transcript variant 1 (from RefSeq NM_028780.3) ENSMUST00000122358.1 ENSMUST00000122358.2 ENSMUST00000122358.3 ENSMUST00000122358.4 ENSMUST00000122358.5 ENSMUST00000122358.6 ENSMUST00000122358.7 NM_028780 Q3U7S4 Q8VD27 Q922J5 Q9DBU0 Q9ET29 TM9S1_MOUSE uc007tzt.1 uc007tzt.2 uc007tzt.3 Plays an essential role in autophagy. Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. autophagosome membrane molecular_function lysosome lysosomal membrane autophagy membrane integral component of membrane cytoplasmic vesicle protein localization to membrane uc007tzt.1 uc007tzt.2 uc007tzt.3 
ENSMUST00000122363.8 Vps9d1 ENSMUST00000122363.8 VPS9 domain containing 1, transcript variant 2 (from RefSeq NM_028200.2) ENSMUST00000122363.1 ENSMUST00000122363.2 ENSMUST00000122363.3 ENSMUST00000122363.4 ENSMUST00000122363.5 ENSMUST00000122363.6 ENSMUST00000122363.7 NM_028200 Q6PFD1 Q8C190 VP9D1_MOUSE uc009nuv.1 uc009nuv.2 uc009nuv.3 uc009nuv.4 uc009nuv.5 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C190-1; Sequence=Displayed; Name=2; IsoId=Q8C190-2; Sequence=VSP_014703, VSP_014704; molecular_function biological_process uc009nuv.1 uc009nuv.2 uc009nuv.3 uc009nuv.4 uc009nuv.5 
ENSMUST00000122365.2 Gm28037 ENSMUST00000122365.2 Gm28037 (from geneSymbol) AK136631 ENSMUST00000122365.1 uc289fbe.1 uc289fbe.2 uc289fbe.1 uc289fbe.2 
ENSMUST00000122367.8 Sel1l2 ENSMUST00000122367.8 sel-1 suppressor of lin-12-like 2 (C. elegans), transcript variant 3 (from RefSeq NR_184864.1) A2AHP5 B0QZY0 ENSMUST00000122367.1 ENSMUST00000122367.2 ENSMUST00000122367.3 ENSMUST00000122367.4 ENSMUST00000122367.5 ENSMUST00000122367.6 ENSMUST00000122367.7 Gm118 NR_184864 Q3V172 SE1L2_MOUSE uc008mpq.1 uc008mpq.2 uc008mpq.3 Membrane; Single-pass type I membrane protein. Belongs to the sel-1 family. Hrd1p ubiquitin ligase ERAD-L complex membrane integral component of membrane protein ubiquitination ER-associated ubiquitin-dependent protein catabolic process ubiquitin-protein transferase activity uc008mpq.1 uc008mpq.2 uc008mpq.3 
ENSMUST00000122375.8 Golga7b ENSMUST00000122375.8 golgin A7B, transcript variant 1 (from RefSeq NM_001141983.1) A8Y5D0 ENSMUST00000122375.1 ENSMUST00000122375.2 ENSMUST00000122375.3 ENSMUST00000122375.4 ENSMUST00000122375.5 ENSMUST00000122375.6 ENSMUST00000122375.7 GOG7B_MOUSE GOLGA7B NM_001141983 Q3UTK8 Q9D428 uc008hnm.1 uc008hnm.2 uc008hnm.3 uc008hnm.4 Play a role in cell adhesion by regulating the plasma membrane localization of the palmitoyltransferase ZDHHC5. May be involved in protein transport from Golgi to cell surface. Q9D428; Q8VDZ4: Zdhhc5; NbExp=2; IntAct=EBI-25635843, EBI-7057556; Cell membrane Golgi apparatus membrane ; Lipid-anchor Palmitoylated by ZDHHC5. Palmitoylation is required for the maintenance of ZDHHC5 at the plasma membrane. Belongs to the ERF4 family. Sequence=BAE23972.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane palmitoyltransferase complex Golgi apparatus protein targeting to membrane membrane peptidyl-L-cysteine S-palmitoylation protein-cysteine S-palmitoyltransferase activity uc008hnm.1 uc008hnm.2 uc008hnm.3 uc008hnm.4 
ENSMUST00000122381.8 Mup9 ENSMUST00000122381.8 major urinary protein 9 (from RefSeq NM_001281979.1) ENSMUST00000122381.1 ENSMUST00000122381.2 ENSMUST00000122381.3 ENSMUST00000122381.4 ENSMUST00000122381.5 ENSMUST00000122381.6 ENSMUST00000122381.7 MUP6_MOUSE Mup6 NM_001281979 P02762 P70119 Q78EF5 Q91V46 uc029uuq.1 uc029uuq.2 uc029uuq.3 uc029uuq.4 Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females. Secreted. Abundant in the urine of adult male mice but absent from that of females. Causes an allergic reaction in human. There are about 15 group 1 MUP genes and their transcripts make up about 5% of male mouse liver RNA. Belongs to the calycin superfamily. Lipocalin family. insulin-activated receptor activity pheromone binding extracellular region extracellular space nucleus cytosol energy reserve metabolic process insulin receptor signaling pathway aerobic respiration positive regulation of gene expression negative regulation of lipid storage positive regulation of glucose metabolic process heat generation small molecule binding glucose homeostasis locomotor rhythm negative regulation of gluconeogenesis positive regulation of lipid metabolic process negative regulation of transcription, DNA-templated negative regulation of lipid biosynthetic process positive regulation of protein kinase B signaling negative regulation of insulin secretion involved in cellular response to glucose stimulus mitochondrion morphogenesis cellular response to lipid uc029uuq.1 uc029uuq.2 uc029uuq.3 uc029uuq.4 
ENSMUST00000122412.2 Ptpn2 ENSMUST00000122412.2 protein tyrosine phosphatase, non-receptor type 2, transcript variant 2 (from RefSeq NM_001127177.1) ENSMUST00000122412.1 NM_001127177 PTN2_MOUSE Ptpt Q06180 Q3V259 Q922E7 uc008fmv.1 uc008fmv.2 uc008fmv.3 uc008fmv.4 Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T- cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Interacts with RMDN3. Isoform 1 interacts with TMED9. Isoform 1 interacts with STX17; dephosphorylates STX17. Interacts with ITGA1 (via cytoplasmic domain); activates the phosphatase activity towards EGFR. Interacts with TRAF2; probably involved in tumor necrosis factor- mediated signaling. Interacts with MET (By similarity). [Isoform 1]: Endoplasmic reticulum Endoplasmic reticulum-Golgi intermediate compartment Note=Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region. [Isoform 2]: Nucleus Cytoplasm Cell membrane Note=Predominantly localizes to chromatin. Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors. Recruited by activated ITGA1 at the plasma membrane (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PTPB, TC-PTPb; IsoId=Q06180-1; Sequence=Displayed; Name=2; Synonyms=PTPA, TC-PTPa; IsoId=Q06180-2; Sequence=VSP_012367; Ubiquitously expressed. The highest expression levels were found in ovary, testis, thymus and kidney. [Isoform 2]: Specifically phosphorylated in a cell cycle-dependent manner by cyclin-dependent kinases CDK1 and CDK2. Probably activated through phosphorylation by PKR. Newborn mice are viable and do not display physical abnormalities. However, by 3 to 5 weeks of age they develop hunched posture, diarrhea and anemia. They do not survive beyond 5 weeks of age due to severe anemia, hematopoietic defects and the development of progressive systemic inflammatory disease. They display splenomegaly, lymphadenopathy and thymic atrophy, associated with altered B-cell differentiation, altered erythropoiesis, and impaired T- and B-cell functions. The inflammatory disease is characterized by high levels of circulating pro-inflammatory cytokines and lymphocytic infiltrates in non-lymphoid tissues. Heterozygous Ptpn2+/- mice exhibit decreased gluconeogenesis and hepatic glucose production while muscle- specific disruption of Ptpn2 has no effect on insulin signaling and glucose homeostasis in this tissue. Belongs to the protein-tyrosine phosphatase family. Non- receptor class 1 subfamily. Was reported to dephosphorylate STAT5A and STAT5B in the nucleus to negatively regulate prolactin-mediated signaling pathway (PubMed:11773439). However, the corresponding article has been retracted (PubMed:24319783). negative regulation of transcription from RNA polymerase II promoter phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity integrin binding protein binding nucleus nucleoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment cytosol plasma membrane protein dephosphorylation negative regulation of cell proliferation insulin receptor signaling pathway negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of lipid storage membrane dephosphorylation hydrolase activity phosphatase activity protein kinase binding syntaxin binding B cell differentiation T cell differentiation erythrocyte differentiation receptor tyrosine kinase binding peptidyl-tyrosine dephosphorylation negative regulation of epidermal growth factor receptor signaling pathway negative regulation of tyrosine phosphorylation of STAT protein glucose homeostasis negative regulation of macrophage differentiation positive regulation of gluconeogenesis negative regulation of insulin receptor signaling pathway negative regulation of inflammatory response negative regulation of T cell receptor signaling pathway negative regulation of chemotaxis negative regulation of interferon-gamma-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of protein tyrosine kinase activity negative regulation of interleukin-6-mediated signaling pathway negative regulation of ERK1 and ERK2 cascade STAT family protein binding regulation of hepatocyte growth factor receptor signaling pathway negative regulation of interleukin-2-mediated signaling pathway negative regulation of interleukin-4-mediated signaling pathway negative regulation of macrophage colony-stimulating factor signaling pathway negative regulation of positive thymic T cell selection positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of PERK-mediated unfolded protein response negative regulation of platelet-derived growth factor receptor-beta signaling pathway uc008fmv.1 uc008fmv.2 uc008fmv.3 uc008fmv.4 
ENSMUST00000122421.2 Ccsap ENSMUST00000122421.2 centriole, cilia and spindle associated protein, transcript variant 2 (from RefSeq NM_028536.1) CCSAP_MOUSE ENSMUST00000122421.1 NM_028536 Q8C3E1 Q8QZT2 uc009nwq.1 uc009nwq.2 Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle. May play a role in embryonic development. May be required for proper cilia beating (By similarity). Associates with microtubules; the association occurs on polyglutamylated tubulin. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, cilium axoneme Cell projection, axon Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to two to four centrioles throughout the cell cycle. Localizes to mitotic spindle microtubules during prometaphase and throughout the remainder of mitosis. Localizes to cytoskeleton on interphase. Localizes at the ciliary transition zone which connects the basal bodies to ciliary microtubules. Colocalizes with polyglutamylated tubulin (By similarity). Belongs to the CCSAP family. Sequence=BAC39624.1; Type=Frameshift; Evidence=; cytoplasm centrosome centriole microtubule organizing center spindle cytoskeleton microtubule cilium axoneme cell cycle multicellular organism development microtubule binding axon ciliary transition zone ciliary basal body cell projection regulation of embryonic development cell division regulation of cilium beat frequency involved in ciliary motility mitotic spindle astral microtubule mitotic spindle regulation of mitotic spindle assembly mitotic spindle microtubule depolymerization uc009nwq.1 uc009nwq.2 
ENSMUST00000122424.8 Fam20b ENSMUST00000122424.8 FAM20B, glycosaminoglycan xylosylkinase, transcript variant 6 (from RefSeq NM_001418037.1) ENSMUST00000122424.1 ENSMUST00000122424.2 ENSMUST00000122424.3 ENSMUST00000122424.4 ENSMUST00000122424.5 ENSMUST00000122424.6 ENSMUST00000122424.7 Fam20b NM_001418037 Q3V201 Q6ZQA3 Q8BWX2 Q8VCS3 XYLK_MOUSE uc057kgz.1 uc057kgz.2 uc057kgz.3 Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O- phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT- I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized. Reaction=3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D- xylosyl)-L-seryl-[protein] + ATP = 3-O-(beta-D-galactosyl-(1->3)- beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+); Xref=Rhea:RHEA:19461, Rhea:RHEA-COMP:12571, Rhea:RHEA- COMP:14558, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:132090, ChEBI:CHEBI:140494, ChEBI:CHEBI:456216; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Golgi apparatus membrane ; Single-pass type II membrane protein Little expression detected in the secretory stage enamel. Weak to moderate expression is observed in the gingivae and odontoblasts. Strong expression in maturation stage ameloblasts. Embryos show severe stunting and increased mortality at 13.5 dpc. Belongs to the FAM20 family. Golgi membrane nucleotide binding ATP binding extracellular space nucleoplasm Golgi apparatus membrane integral component of membrane kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor proteoglycan biosynthetic process metal ion binding protein phosphorylation uc057kgz.1 uc057kgz.2 uc057kgz.3 
ENSMUST00000122446.2 H2ab1 ENSMUST00000122446.2 H2A.B variant histone 1 (from RefSeq NM_001102665.1) ENSMUST00000122446.1 Gm14920 H2ab1 NM_001102665 S4R1E0 S4R1E0_MOUSE uc009vfg.1 uc009vfg.2 The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2A family. nucleosome nuclear nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization transcriptionally active chromatin protein heterodimerization activity uc009vfg.1 uc009vfg.2 
ENSMUST00000122447.3 H3f4 ENSMUST00000122447.3 H3.4 histone, cluster member (from RefSeq NM_001318003.2) A0A8I4SYN6 A0A8I4SYN6_MOUSE ENSMUST00000122447.1 ENSMUST00000122447.2 H3f4 NM_001318003 mCG_140136 uc287ylt.1 uc287ylt.2 uc287ylt.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. [provided by RefSeq, Dec 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 26388943 ##RefSeq-Attributes-END## The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H3 family. uc287ylt.1 uc287ylt.2 uc287ylt.3 
ENSMUST00000122468.4 Gm23463 ENSMUST00000122468.4 Gm23463 (from geneSymbol) DQ558729 ENSMUST00000122468.1 ENSMUST00000122468.2 ENSMUST00000122468.3 uc290cbz.1 uc290cbz.2 uc290cbz.1 uc290cbz.2 
ENSMUST00000122472.3 Gm25107 ENSMUST00000122472.3 Gm25107 (from geneSymbol) ENSMUST00000122472.1 ENSMUST00000122472.2 uc292qzv.1 uc292qzv.2 uc292qzv.1 uc292qzv.2 
ENSMUST00000122476.3 Gm25104 ENSMUST00000122476.3 Gm25104 (from geneSymbol) ENSMUST00000122476.1 ENSMUST00000122476.2 uc289kys.1 uc289kys.2 uc289kys.1 uc289kys.2 
ENSMUST00000122479.3 Gm25102 ENSMUST00000122479.3 Gm25102 (from geneSymbol) ENSMUST00000122479.1 ENSMUST00000122479.2 uc289mgk.1 uc289mgk.2 uc289mgk.1 uc289mgk.2 
ENSMUST00000122486.4 Gm23429 ENSMUST00000122486.4 Gm23429 (from geneSymbol) ENSMUST00000122486.1 ENSMUST00000122486.2 ENSMUST00000122486.3 uc290wqf.1 uc290wqf.2 uc290wqf.1 uc290wqf.2 
ENSMUST00000122488.3 Gm23428 ENSMUST00000122488.3 Gm23428 (from geneSymbol) ENSMUST00000122488.1 ENSMUST00000122488.2 uc292ihq.1 uc292ihq.2 uc292ihq.1 uc292ihq.2 
ENSMUST00000122491.4 Gm26254 ENSMUST00000122491.4 Gm26254 (from geneSymbol) ENSMUST00000122491.1 ENSMUST00000122491.2 ENSMUST00000122491.3 uc290lpb.1 uc290lpb.2 uc290lpb.1 uc290lpb.2 
ENSMUST00000122492.3 Gm26255 ENSMUST00000122492.3 Gm26255 (from geneSymbol) ENSMUST00000122492.1 ENSMUST00000122492.2 uc288wjz.1 uc288wjz.2 uc288wjz.1 uc288wjz.2 
ENSMUST00000122493.4 Gm26253 ENSMUST00000122493.4 Gm26253 (from geneSymbol) ENSMUST00000122493.1 ENSMUST00000122493.2 ENSMUST00000122493.3 uc287wuz.1 uc287wuz.2 uc287wuz.1 uc287wuz.2 
ENSMUST00000122498.3 Gm26251 ENSMUST00000122498.3 Gm26251 (from geneSymbol) ENSMUST00000122498.1 ENSMUST00000122498.2 uc288vvo.1 uc288vvo.2 uc288vvo.1 uc288vvo.2 
ENSMUST00000122499.3 Gm26256 ENSMUST00000122499.3 Gm26256 (from geneSymbol) ENSMUST00000122499.1 ENSMUST00000122499.2 uc288gvb.1 uc288gvb.2 uc288gvb.1 uc288gvb.2 
ENSMUST00000122500.3 Gm26257 ENSMUST00000122500.3 Gm26257 (from geneSymbol) ENSMUST00000122500.1 ENSMUST00000122500.2 uc287rcg.1 uc287rcg.2 uc287rcg.1 uc287rcg.2 
ENSMUST00000122501.4 Gm24595 ENSMUST00000122501.4 Gm24595 (from geneSymbol) ENSMUST00000122501.1 ENSMUST00000122501.2 ENSMUST00000122501.3 uc292plq.1 uc292plq.2 uc292plq.1 uc292plq.2 
ENSMUST00000122504.3 Gm24596 ENSMUST00000122504.3 Gm24596 (from geneSymbol) DQ558729 ENSMUST00000122504.1 ENSMUST00000122504.2 uc291vks.1 uc291vks.2 uc291vks.1 uc291vks.2 
ENSMUST00000122505.3 Gm24592 ENSMUST00000122505.3 Gm24592 (from geneSymbol) ENSMUST00000122505.1 ENSMUST00000122505.2 uc291ikc.1 uc291ikc.2 uc291ikc.1 uc291ikc.2 
ENSMUST00000122507.4 Gm24593 ENSMUST00000122507.4 Gm24593 (from geneSymbol) ENSMUST00000122507.1 ENSMUST00000122507.2 ENSMUST00000122507.3 uc290hdd.1 uc290hdd.2 uc290hdd.1 uc290hdd.2 
ENSMUST00000122509.3 Mir1907 ENSMUST00000122509.3 microRNA 1907 (from RefSeq NR_035444.1) ENSMUST00000122509.1 ENSMUST00000122509.2 NR_035444 uc011zsu.1 uc011zsu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011zsu.1 uc011zsu.2 
ENSMUST00000122510.3 Gm24598 ENSMUST00000122510.3 Gm24598 (from geneSymbol) ENSMUST00000122510.1 ENSMUST00000122510.2 uc292oks.1 uc292oks.2 uc292oks.1 uc292oks.2 
ENSMUST00000122512.4 Gm22958 ENSMUST00000122512.4 Gm22958 (from geneSymbol) DQ562105 ENSMUST00000122512.1 ENSMUST00000122512.2 ENSMUST00000122512.3 uc287vjf.1 uc287vjf.2 uc287vjf.1 uc287vjf.2 
ENSMUST00000122517.4 Gm22960 ENSMUST00000122517.4 Gm22960 (from geneSymbol) ENSMUST00000122517.1 ENSMUST00000122517.2 ENSMUST00000122517.3 uc288moz.1 uc288moz.2 uc288moz.1 uc288moz.2 
ENSMUST00000122520.4 Gm22956 ENSMUST00000122520.4 Gm22956 (from geneSymbol) ENSMUST00000122520.1 ENSMUST00000122520.2 ENSMUST00000122520.3 uc291bbl.1 uc291bbl.2 uc291bbl.1 uc291bbl.2 
ENSMUST00000122524.4 Gm25784 ENSMUST00000122524.4 Gm25784 (from geneSymbol) ENSMUST00000122524.1 ENSMUST00000122524.2 ENSMUST00000122524.3 uc291ouf.1 uc291ouf.2 uc291ouf.1 uc291ouf.2 
ENSMUST00000122525.4 Gm25783 ENSMUST00000122525.4 Gm25783 (from geneSymbol) ENSMUST00000122525.1 ENSMUST00000122525.2 ENSMUST00000122525.3 uc289lgj.1 uc289lgj.2 uc289lgj.1 uc289lgj.2 
ENSMUST00000122527.4 Gm25781 ENSMUST00000122527.4 Gm25781 (from geneSymbol) DQ558729 ENSMUST00000122527.1 ENSMUST00000122527.2 ENSMUST00000122527.3 uc288wnq.1 uc288wnq.2 uc288wnq.1 uc288wnq.2 
ENSMUST00000122529.4 Gm26425 ENSMUST00000122529.4 Gm26425 (from geneSymbol) ENSMUST00000122529.1 ENSMUST00000122529.2 ENSMUST00000122529.3 uc290oaw.1 uc290oaw.2 uc290oaw.1 uc290oaw.2 
ENSMUST00000122530.2 Gm26424 ENSMUST00000122530.2 Gm26424 (from geneSymbol) ENSMUST00000122530.1 uc290mrc.1 uc290mrc.2 uc290mrc.1 uc290mrc.2 
ENSMUST00000122535.4 Gm23788 ENSMUST00000122535.4 Gm23788 (from geneSymbol) ENSMUST00000122535.1 ENSMUST00000122535.2 ENSMUST00000122535.3 uc291vgo.1 uc291vgo.2 uc291vgo.1 uc291vgo.2 
ENSMUST00000122538.3 Gm23787 ENSMUST00000122538.3 Gm23787 (from geneSymbol) ENSMUST00000122538.1 ENSMUST00000122538.2 uc288jex.1 uc288jex.2 uc288jex.1 uc288jex.2 
ENSMUST00000122544.3 Gm22106 ENSMUST00000122544.3 Gm22106 (from geneSymbol) ENSMUST00000122544.1 ENSMUST00000122544.2 uc288yqd.1 uc288yqd.2 uc288yqd.1 uc288yqd.2 
ENSMUST00000122548.3 Gm22107 ENSMUST00000122548.3 Gm22107 (from geneSymbol) AK052845 ENSMUST00000122548.1 ENSMUST00000122548.2 uc288zjk.1 uc288zjk.2 uc288zjk.1 uc288zjk.2 
ENSMUST00000122555.3 Gm25323 ENSMUST00000122555.3 Gm25323 (from geneSymbol) ENSMUST00000122555.1 ENSMUST00000122555.2 uc290pvr.1 uc290pvr.2 uc290pvr.1 uc290pvr.2 
ENSMUST00000122556.4 Gm25322 ENSMUST00000122556.4 Gm25322 (from geneSymbol) ENSMUST00000122556.1 ENSMUST00000122556.2 ENSMUST00000122556.3 uc287ldu.1 uc287ldu.2 uc287ldu.1 uc287ldu.2 
ENSMUST00000122557.3 Gm23792 ENSMUST00000122557.3 Gm23792 (from geneSymbol) ENSMUST00000122557.1 ENSMUST00000122557.2 uc287hcv.1 uc287hcv.2 uc287hcv.1 uc287hcv.2 
ENSMUST00000122558.3 Gm25321 ENSMUST00000122558.3 Gm25321 (from geneSymbol) DQ558729 ENSMUST00000122558.1 ENSMUST00000122558.2 uc292ddj.1 uc292ddj.2 uc292ddj.1 uc292ddj.2 
ENSMUST00000122560.3 Gm25524 ENSMUST00000122560.3 Gm25524 (from geneSymbol) DQ558729 ENSMUST00000122560.1 ENSMUST00000122560.2 uc287lwb.1 uc287lwb.2 uc287lwb.1 uc287lwb.2 
ENSMUST00000122565.2 Mir1893 ENSMUST00000122565.2 microRNA 1893 (from RefSeq NR_035446.1) ENSMUST00000122565.1 NR_035446 uc012azb.1 uc012azb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610375.1 [ECO:0000345] ##Evidence-Data-END## uc012azb.1 uc012azb.2 
ENSMUST00000122566.4 Gm22479 ENSMUST00000122566.4 Gm22479 (from geneSymbol) ENSMUST00000122566.1 ENSMUST00000122566.2 ENSMUST00000122566.3 uc292mal.1 uc292mal.2 uc292mal.1 uc292mal.2 
ENSMUST00000122567.3 Mir1902 ENSMUST00000122567.3 microRNA 1902 (from RefSeq NR_035432.1) ENSMUST00000122567.1 ENSMUST00000122567.2 NR_035432 uc012cap.1 uc012cap.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610373.1 [ECO:0000345] ##Evidence-Data-END## uc012cap.1 uc012cap.2 
ENSMUST00000122568.3 Gm22480 ENSMUST00000122568.3 Gm22480 (from geneSymbol) ENSMUST00000122568.1 ENSMUST00000122568.2 uc290fap.1 uc290fap.2 uc290fap.1 uc290fap.2 
ENSMUST00000122572.3 Gm24183 ENSMUST00000122572.3 Gm24183 (from geneSymbol) ENSMUST00000122572.1 ENSMUST00000122572.2 uc289pdr.1 uc289pdr.2 uc289pdr.1 uc289pdr.2 
ENSMUST00000122574.3 Mir1903 ENSMUST00000122574.3 microRNA 1903 (from RefSeq NR_035436.1) ENSMUST00000122574.1 ENSMUST00000122574.2 NR_035436 uc012gng.1 uc012gng.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012gng.1 uc012gng.2 
ENSMUST00000122578.3 Gm24185 ENSMUST00000122578.3 Gm24185 (from geneSymbol) ENSMUST00000122578.1 ENSMUST00000122578.2 uc290har.1 uc290har.2 uc290har.1 uc290har.2 
ENSMUST00000122586.3 Mir1906-1 ENSMUST00000122586.3 microRNA 1906-1 (from RefSeq NR_035440.1) ENSMUST00000122586.1 ENSMUST00000122586.2 NR_035440 uc011ysa.1 uc011ysa.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011ysa.1 uc011ysa.2 
ENSMUST00000122600.3 DQ267100 ENSMUST00000122600.3 snoRNA DQ267100 (from RefSeq NR_046304.1) ENSMUST00000122600.1 ENSMUST00000122600.2 NR_046304 uc288jeh.1 uc288jeh.2 uc288jeh.1 uc288jeh.2 
ENSMUST00000122601.3 Gm25269 ENSMUST00000122601.3 Gm25269 (from geneSymbol) ENSMUST00000122601.1 ENSMUST00000122601.2 uc287ovs.1 uc287ovs.2 uc287ovs.1 uc287ovs.2 
ENSMUST00000122602.3 Gm24839 ENSMUST00000122602.3 Gm24839 (from geneSymbol) ENSMUST00000122602.1 ENSMUST00000122602.2 uc290zzr.1 uc290zzr.2 uc290zzr.1 uc290zzr.2 
ENSMUST00000122603.4 Gm24840 ENSMUST00000122603.4 Gm24840 (from geneSymbol) DQ562105 ENSMUST00000122603.1 ENSMUST00000122603.2 ENSMUST00000122603.3 uc290zqt.1 uc290zqt.2 uc290zqt.1 uc290zqt.2 
ENSMUST00000122606.3 Gm25270 ENSMUST00000122606.3 Gm25270 (from geneSymbol) ENSMUST00000122606.1 ENSMUST00000122606.2 uc290qpq.1 uc290qpq.2 uc290qpq.1 uc290qpq.2 
ENSMUST00000122608.4 Gm25279 ENSMUST00000122608.4 Gm25279 (from geneSymbol) ENSMUST00000122608.1 ENSMUST00000122608.2 ENSMUST00000122608.3 uc287mod.1 uc287mod.2 uc287mod.1 uc287mod.2 
ENSMUST00000122609.3 Gm24836 ENSMUST00000122609.3 Gm24836 (from geneSymbol) ENSMUST00000122609.1 ENSMUST00000122609.2 uc287olv.1 uc287olv.2 uc287olv.1 uc287olv.2 
ENSMUST00000122610.3 Mir1906-2 ENSMUST00000122610.3 microRNA 1906-2 (from RefSeq NR_037313.1) ENSMUST00000122610.1 ENSMUST00000122610.2 NR_037313 uc012hlo.1 uc012hlo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012hlo.1 uc012hlo.2 
ENSMUST00000122611.3 Gm26478 ENSMUST00000122611.3 Gm26478 (from geneSymbol) ENSMUST00000122611.1 ENSMUST00000122611.2 uc289szn.1 uc289szn.2 uc289szn.1 uc289szn.2 
ENSMUST00000122615.3 Mir1895 ENSMUST00000122615.3 microRNA 1895 (from RefSeq NR_035435.1) ENSMUST00000122615.1 ENSMUST00000122615.2 NR_035435 uc012cya.1 uc012cya.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012cya.1 uc012cya.2 
ENSMUST00000122616.3 Mir1901 ENSMUST00000122616.3 microRNA 1901 (from RefSeq NR_035447.1) ENSMUST00000122616.1 ENSMUST00000122616.2 NR_035447 uc012azj.1 uc012azj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012azj.1 uc012azj.2 
ENSMUST00000122620.3 Gm26479 ENSMUST00000122620.3 Gm26479 (from geneSymbol) ENSMUST00000122620.1 ENSMUST00000122620.2 uc287rrt.1 uc287rrt.2 uc287rrt.1 uc287rrt.2 
ENSMUST00000122621.3 Gm26271 ENSMUST00000122621.3 Gm26271 (from geneSymbol) ENSMUST00000122621.1 ENSMUST00000122621.2 uc287mgn.1 uc287mgn.2 uc287mgn.1 uc287mgn.2 
ENSMUST00000122626.3 Gm23656 ENSMUST00000122626.3 Gm23656 (from geneSymbol) ENSMUST00000122626.1 ENSMUST00000122626.2 uc292pzv.1 uc292pzv.2 uc292pzv.1 uc292pzv.2 
ENSMUST00000122627.3 Gm23655 ENSMUST00000122627.3 Gm23655 (from geneSymbol) ENSMUST00000122627.1 ENSMUST00000122627.2 uc289fwd.1 uc289fwd.2 uc289fwd.1 uc289fwd.2 
ENSMUST00000122630.4 Gm23661 ENSMUST00000122630.4 Gm23661 (from geneSymbol) ENSMUST00000122630.1 ENSMUST00000122630.2 ENSMUST00000122630.3 uc290wek.1 uc290wek.2 uc290wek.1 uc290wek.2 
ENSMUST00000122634.4 Gm25177 ENSMUST00000122634.4 Gm25177 (from geneSymbol) ENSMUST00000122634.1 ENSMUST00000122634.2 ENSMUST00000122634.3 uc289lvk.1 uc289lvk.2 uc289lvk.1 uc289lvk.2 
ENSMUST00000122640.4 Gm25176 ENSMUST00000122640.4 Gm25176 (from geneSymbol) ENSMUST00000122640.1 ENSMUST00000122640.2 ENSMUST00000122640.3 uc289rly.1 uc289rly.2 uc289rly.1 uc289rly.2 
ENSMUST00000122641.3 Mir1896 ENSMUST00000122641.3 microRNA 1896 (from RefSeq NR_035441.1) ENSMUST00000122641.1 ENSMUST00000122641.2 NR_035441 uc011yws.1 uc011yws.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011yws.1 uc011yws.2 
ENSMUST00000122643.3 Mir1898 ENSMUST00000122643.3 microRNA 1898 (from RefSeq NR_035443.1) ENSMUST00000122643.1 ENSMUST00000122643.2 NR_035443 uc011zrj.1 uc011zrj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011zrj.1 uc011zrj.2 
ENSMUST00000122644.3 Gm22345 ENSMUST00000122644.3 Gm22345 (from geneSymbol) ENSMUST00000122644.1 ENSMUST00000122644.2 uc290ont.1 uc290ont.2 uc290ont.1 uc290ont.2 
ENSMUST00000122652.4 Gm23111 ENSMUST00000122652.4 Gm23111 (from geneSymbol) ENSMUST00000122652.1 ENSMUST00000122652.2 ENSMUST00000122652.3 uc289jzr.1 uc289jzr.2 uc289jzr.1 uc289jzr.2 
ENSMUST00000122655.3 Gm22205 ENSMUST00000122655.3 Gm22205 (from geneSymbol) ENSMUST00000122655.1 ENSMUST00000122655.2 uc288jez.1 uc288jez.2 uc288jez.1 uc288jez.2 
ENSMUST00000122657.3 Gm23118 ENSMUST00000122657.3 Gm23118 (from geneSymbol) ENSMUST00000122657.1 ENSMUST00000122657.2 uc289stg.1 uc289stg.2 uc289stg.1 uc289stg.2 
ENSMUST00000122658.3 Gm22208 ENSMUST00000122658.3 Gm22208 (from geneSymbol) ENSMUST00000122658.1 ENSMUST00000122658.2 uc288xmt.1 uc288xmt.2 uc288xmt.1 uc288xmt.2 
ENSMUST00000122660.4 Gm22199 ENSMUST00000122660.4 Gm22199 (from geneSymbol) ENSMUST00000122660.1 ENSMUST00000122660.2 ENSMUST00000122660.3 uc288mug.1 uc288mug.2 uc288mug.1 uc288mug.2 
ENSMUST00000122661.4 Gm25052 ENSMUST00000122661.4 Gm25052 (from geneSymbol) ENSMUST00000122661.1 ENSMUST00000122661.2 ENSMUST00000122661.3 uc292ayz.1 uc292ayz.2 uc292ayz.1 uc292ayz.2 
ENSMUST00000122667.3 Gm25047 ENSMUST00000122667.3 Gm25047 (from geneSymbol) BC058671 ENSMUST00000122667.1 ENSMUST00000122667.2 uc292nru.1 uc292nru.2 uc292nru.1 uc292nru.2 
ENSMUST00000122668.3 Gm22073 ENSMUST00000122668.3 Gm22073 (from geneSymbol) ENSMUST00000122668.1 ENSMUST00000122668.2 uc290fuz.1 uc290fuz.2 uc290fuz.1 uc290fuz.2 
ENSMUST00000122670.3 Gm25045 ENSMUST00000122670.3 Gm25045 (from geneSymbol) ENSMUST00000122670.1 ENSMUST00000122670.2 uc292iow.1 uc292iow.2 uc292iow.1 uc292iow.2 
ENSMUST00000122672.4 Gm25106 ENSMUST00000122672.4 Gm25106 (from geneSymbol) DQ562105 ENSMUST00000122672.1 ENSMUST00000122672.2 ENSMUST00000122672.3 uc288byq.1 uc288byq.2 uc288byq.1 uc288byq.2 
ENSMUST00000122677.3 Gm25985 ENSMUST00000122677.3 Gm25985 (from geneSymbol) ENSMUST00000122677.1 ENSMUST00000122677.2 uc288qcs.1 uc288qcs.2 uc288qcs.1 uc288qcs.2 
ENSMUST00000122680.3 Gm25112 ENSMUST00000122680.3 Gm25112 (from geneSymbol) ENSMUST00000122680.1 ENSMUST00000122680.2 uc288ker.1 uc288ker.2 uc288ker.1 uc288ker.2 
ENSMUST00000122683.3 Gm23887 ENSMUST00000122683.3 Gm23887 (from geneSymbol) ENSMUST00000122683.1 ENSMUST00000122683.2 LF200993 uc289jeb.1 uc289jeb.2 uc289jeb.1 uc289jeb.2 
ENSMUST00000122689.3 Gm23889 ENSMUST00000122689.3 Gm23889 (from geneSymbol) ENSMUST00000122689.1 ENSMUST00000122689.2 uc292lyl.1 uc292lyl.2 uc292lyl.1 uc292lyl.2 
ENSMUST00000122695.3 Gm24379 ENSMUST00000122695.3 Gm24379 (from geneSymbol) ENSMUST00000122695.1 ENSMUST00000122695.2 uc290cdv.1 uc290cdv.2 uc290cdv.1 uc290cdv.2 
ENSMUST00000122697.3 Gm24381 ENSMUST00000122697.3 Gm24381 (from geneSymbol) ENSMUST00000122697.1 ENSMUST00000122697.2 uc290ryp.1 uc290ryp.2 uc290ryp.1 uc290ryp.2 
ENSMUST00000122698.3 Gm24382 ENSMUST00000122698.3 Gm24382 (from geneSymbol) ENSMUST00000122698.1 ENSMUST00000122698.2 uc290fnl.1 uc290fnl.2 uc290fnl.1 uc290fnl.2 
ENSMUST00000122699.4 Gm24378 ENSMUST00000122699.4 Gm24378 (from geneSymbol) ENSMUST00000122699.1 ENSMUST00000122699.2 ENSMUST00000122699.3 uc288tdj.1 uc288tdj.2 uc288tdj.1 uc288tdj.2 
ENSMUST00000122702.3 Mir1904 ENSMUST00000122702.3 microRNA 1904 (from RefSeq NR_035442.1) ENSMUST00000122702.1 ENSMUST00000122702.2 NR_035442 uc011zem.1 uc011zem.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011zem.1 uc011zem.2 
ENSMUST00000122703.3 Gm22717 ENSMUST00000122703.3 Gm22717 (from geneSymbol) ENSMUST00000122703.1 ENSMUST00000122703.2 uc292jpc.1 uc292jpc.2 uc292jpc.1 uc292jpc.2 
ENSMUST00000122704.4 Gm26091 ENSMUST00000122704.4 Gm26091 (from geneSymbol) ENSMUST00000122704.1 ENSMUST00000122704.2 ENSMUST00000122704.3 uc290iix.1 uc290iix.2 uc290iix.1 uc290iix.2 
ENSMUST00000122710.3 Gm22720 ENSMUST00000122710.3 Gm22720 (from geneSymbol) ENSMUST00000122710.1 ENSMUST00000122710.2 uc292klx.1 uc292klx.2 uc292klx.1 uc292klx.2 
ENSMUST00000122712.4 Gm24635 ENSMUST00000122712.4 Gm24635 (from geneSymbol) ENSMUST00000122712.1 ENSMUST00000122712.2 ENSMUST00000122712.3 uc288oui.1 uc288oui.2 uc288oui.1 uc288oui.2 
ENSMUST00000122714.3 Mir1900 ENSMUST00000122714.3 microRNA 1900 (from RefSeq NR_035438.1) ENSMUST00000122714.1 ENSMUST00000122714.2 NR_035438 uc012gpa.1 uc012gpa.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012gpa.1 uc012gpa.2 
ENSMUST00000122716.3 Gm23214 ENSMUST00000122716.3 Gm23214 (from geneSymbol) ENSMUST00000122716.1 ENSMUST00000122716.2 uc290eld.1 uc290eld.2 uc290eld.1 uc290eld.2 
ENSMUST00000122718.3 Gm23212 ENSMUST00000122718.3 Gm23212 (from geneSymbol) ENSMUST00000122718.1 ENSMUST00000122718.2 uc287ncc.1 uc287ncc.2 uc287ncc.1 uc287ncc.2 
ENSMUST00000122720.3 Gm23206 ENSMUST00000122720.3 Gm23206 (from geneSymbol) ENSMUST00000122720.1 ENSMUST00000122720.2 uc288lsn.1 uc288lsn.2 uc288lsn.1 uc288lsn.2 
ENSMUST00000122729.3 Gm26020 ENSMUST00000122729.3 Gm26020 (from geneSymbol) ENSMUST00000122729.1 ENSMUST00000122729.2 uc292pzk.1 uc292pzk.2 uc292pzk.1 uc292pzk.2 
ENSMUST00000122737.3 Gm22027 ENSMUST00000122737.3 Gm22027 (from geneSymbol) ENSMUST00000122737.1 ENSMUST00000122737.2 uc290htf.1 uc290htf.2 uc290htf.1 uc290htf.2 
ENSMUST00000122741.2 Gm24896 ENSMUST00000122741.2 Gm24896 (from geneSymbol) ENSMUST00000122741.1 uc292ehd.1 uc292ehd.2 uc292ehd.1 uc292ehd.2 
ENSMUST00000122742.3 Gm24895 ENSMUST00000122742.3 Gm24895 (from geneSymbol) ENSMUST00000122742.1 ENSMUST00000122742.2 LF199329 uc288jee.1 uc288jee.2 uc288jee.1 uc288jee.2 
ENSMUST00000122747.3 Gm24892 ENSMUST00000122747.3 Gm24892 (from geneSymbol) ENSMUST00000122747.1 ENSMUST00000122747.2 uc290dlx.1 uc290dlx.2 uc290dlx.1 uc290dlx.2 
ENSMUST00000122751.4 Gm22984 ENSMUST00000122751.4 Gm22984 (from geneSymbol) ENSMUST00000122751.1 ENSMUST00000122751.2 ENSMUST00000122751.3 uc288wdv.1 uc288wdv.2 uc288wdv.1 uc288wdv.2 
ENSMUST00000122754.4 Gm22985 ENSMUST00000122754.4 Gm22985 (from geneSymbol) ENSMUST00000122754.1 ENSMUST00000122754.2 ENSMUST00000122754.3 uc292jln.1 uc292jln.2 uc292jln.1 uc292jln.2 
ENSMUST00000122762.3 Gm24629 ENSMUST00000122762.3 Gm24629 (from geneSymbol) ENSMUST00000122762.1 ENSMUST00000122762.2 uc292cti.1 uc292cti.2 uc292cti.1 uc292cti.2 
ENSMUST00000122764.5 Mir1911 ENSMUST00000122764.5 microRNA 1911 (from RefSeq NR_162774.1) ENSMUST00000122764.1 ENSMUST00000122764.2 ENSMUST00000122764.3 ENSMUST00000122764.4 NR_162774 uc292qzp.1 uc292qzp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc292qzp.1 uc292qzp.2 
ENSMUST00000122765.4 Gm24631 ENSMUST00000122765.4 Gm24631 (from geneSymbol) DQ558729 ENSMUST00000122765.1 ENSMUST00000122765.2 ENSMUST00000122765.3 uc292kmg.1 uc292kmg.2 uc292kmg.1 uc292kmg.2 
ENSMUST00000122768.4 Gm24630 ENSMUST00000122768.4 Gm24630 (from geneSymbol) ENSMUST00000122768.1 ENSMUST00000122768.2 ENSMUST00000122768.3 uc291cdf.1 uc291cdf.2 uc291cdf.1 uc291cdf.2 
ENSMUST00000122776.5 Gm24141 ENSMUST00000122776.5 Gm24141 (from geneSymbol) ENSMUST00000122776.1 ENSMUST00000122776.2 ENSMUST00000122776.3 ENSMUST00000122776.4 uc292itq.1 uc292itq.2 uc292itq.1 uc292itq.2 
ENSMUST00000122779.3 Mir1905 ENSMUST00000122779.3 microRNA 1905 (from RefSeq NR_035434.1) ENSMUST00000122779.1 ENSMUST00000122779.2 NR_035434 uc012cry.1 uc012cry.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012cry.1 uc012cry.2 
ENSMUST00000122782.4 Gm25806 ENSMUST00000122782.4 Gm25806 (from geneSymbol) ENSMUST00000122782.1 ENSMUST00000122782.2 ENSMUST00000122782.3 uc290wsa.1 uc290wsa.2 uc290wsa.1 uc290wsa.2 
ENSMUST00000122785.4 Gm25483 ENSMUST00000122785.4 Gm25483 (from geneSymbol) ENSMUST00000122785.1 ENSMUST00000122785.2 ENSMUST00000122785.3 uc288kur.1 uc288kur.2 uc288kur.1 uc288kur.2 
ENSMUST00000122788.3 Gm25805 ENSMUST00000122788.3 Gm25805 (from geneSymbol) DQ558729 ENSMUST00000122788.1 ENSMUST00000122788.2 uc289cib.1 uc289cib.2 uc289cib.1 uc289cib.2 
ENSMUST00000122790.4 Gm22067 ENSMUST00000122790.4 Gm22067 (from geneSymbol) ENSMUST00000122790.1 ENSMUST00000122790.2 ENSMUST00000122790.3 uc288zxs.1 uc288zxs.2 uc288zxs.1 uc288zxs.2 
ENSMUST00000122791.3 Gm25294 ENSMUST00000122791.3 Gm25294 (from geneSymbol) ENSMUST00000122791.1 ENSMUST00000122791.2 uc287gxz.1 uc287gxz.2 uc287gxz.1 uc287gxz.2 
ENSMUST00000122796.3 Gm25290 ENSMUST00000122796.3 Gm25290 (from geneSymbol) ENSMUST00000122796.1 ENSMUST00000122796.2 uc290xba.1 uc290xba.2 uc290xba.1 uc290xba.2 
ENSMUST00000122798.3 Mir1899 ENSMUST00000122798.3 microRNA 1899 (from RefSeq NR_035437.1) ENSMUST00000122798.1 ENSMUST00000122798.2 NR_035437 uc012gnx.1 uc012gnx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012gnx.1 uc012gnx.2 
ENSMUST00000122799.3 Gm25289 ENSMUST00000122799.3 Gm25289 (from geneSymbol) ENSMUST00000122799.1 ENSMUST00000122799.2 uc289oau.1 uc289oau.2 uc289oau.1 uc289oau.2 
ENSMUST00000122802.3 Mir1894 ENSMUST00000122802.3 microRNA 1894 (from RefSeq NR_035445.1) ENSMUST00000122802.1 ENSMUST00000122802.2 NR_035445 uc012arx.1 uc012arx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012arx.1 uc012arx.2 
ENSMUST00000122803.3 Gm22451 ENSMUST00000122803.3 Gm22451 (from geneSymbol) DQ562105 ENSMUST00000122803.1 ENSMUST00000122803.2 uc290fya.1 uc290fya.2 uc290fya.1 uc290fya.2 
ENSMUST00000122804.3 Gm22452 ENSMUST00000122804.3 Gm22452 (from geneSymbol) ENSMUST00000122804.1 ENSMUST00000122804.2 uc288lmc.1 uc288lmc.2 uc288lmc.1 uc288lmc.2 
ENSMUST00000122808.2 Cxcl11 ENSMUST00000122808.2 chemokine (C-X-C motif) ligand 11, transcript variant 1, non-coding (from RefSeq NR_038116.1) ENSMUST00000122808.1 NR_038116 uc029vjk.1 uc029vjk.2 uc029vjk.3 uc029vjk.4 uc029vjk.1 uc029vjk.2 uc029vjk.3 uc029vjk.4 
ENSMUST00000122821.3 4930555O08Rik ENSMUST00000122821.3 4930555O08Rik (from geneSymbol) AK016136 ENSMUST00000122821.1 ENSMUST00000122821.2 uc287xid.1 uc287xid.2 uc287xid.3 uc287xid.1 uc287xid.2 uc287xid.3 
ENSMUST00000122839.2 Gm12404 ENSMUST00000122839.2 Gm12404 (from geneSymbol) AK086793 ENSMUST00000122839.1 uc008sjb.1 uc008sjb.2 uc008sjb.3 uc008sjb.1 uc008sjb.2 uc008sjb.3 
ENSMUST00000122851.3 Gm13686 ENSMUST00000122851.3 Gm13686 (from geneSymbol) ENSMUST00000122851.1 ENSMUST00000122851.2 uc289xjh.1 uc289xjh.2 uc289xjh.3 uc289xjh.1 uc289xjh.2 uc289xjh.3 
ENSMUST00000122854.2 Gm12356 ENSMUST00000122854.2 Gm12356 (from geneSymbol) AK143756 ENSMUST00000122854.1 uc288bzd.1 uc288bzd.2 uc288bzd.1 uc288bzd.2 
ENSMUST00000122872.9 Pgbd1 ENSMUST00000122872.9 piggyBac transposable element derived 1, transcript variant 3 (from RefSeq NM_001012311.2) E9Q2C6 E9Q2C6_MOUSE ENSMUST00000122872.1 ENSMUST00000122872.2 ENSMUST00000122872.3 ENSMUST00000122872.4 ENSMUST00000122872.5 ENSMUST00000122872.6 ENSMUST00000122872.7 ENSMUST00000122872.8 NM_001012311 Pgbd1 uc011ywq.1 uc011ywq.2 uc011ywq.3 identical protein binding uc011ywq.1 uc011ywq.2 uc011ywq.3 
ENSMUST00000122904.2 Gm15556 ENSMUST00000122904.2 Gm15556 (from geneSymbol) ENSMUST00000122904.1 uc289lsf.1 uc289lsf.2 uc289lsf.1 uc289lsf.2 
ENSMUST00000122910.3 Ccdc201 ENSMUST00000122910.3 coiled coil domain 201 (from RefSeq NR_045101.1) A0A1B0GS61 A0A1B0GS61_MOUSE Ccdc201 ENSMUST00000122910.1 ENSMUST00000122910.2 Gm11985 NR_045101 uc029rko.1 uc029rko.2 uc029rko.3 uc029rko.1 uc029rko.2 uc029rko.3 
ENSMUST00000122922.10 Rfx6 ENSMUST00000122922.10 regulatory factor X, 6, transcript variant 1 (from RefSeq NM_001159389.1) ENSMUST00000122922.1 ENSMUST00000122922.2 ENSMUST00000122922.3 ENSMUST00000122922.4 ENSMUST00000122922.5 ENSMUST00000122922.6 ENSMUST00000122922.7 ENSMUST00000122922.8 ENSMUST00000122922.9 NM_001159389 Q8C7R7 Q8CDN5 RFX6_MOUSE Rfxdc1 uc011xdr.1 uc011xdr.2 uc011xdr.3 Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide- producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (By similarity). Interacts with RFX3 (PubMed:20148032). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C7R7-1; Sequence=Displayed; Name=2; IsoId=Q8C7R7-2; Sequence=VSP_030122, VSP_030123; Name=3; IsoId=Q8C7R7-3; Sequence=VSP_030121; In the adult pancreas, expression is restricted to the islets where it could be detected in all endocrine lineages. Expressed initially broadly in the definitive endoderm after gastrulation, becomes restricted to the gut and pancreatic bud at mid gestation, and is reactivated by Neurog3 in islet progenitor cells and is ultimately restricted to pancreatic islets in the mature pancreas (at protein level). By Neurog3. Mice were born at the expected Mendelian ratio, but fail to feed normally, exhibit gross bowel distension due to small bowel obstruction and die within 2 days post partum. Some, but not all, of the animals also have reduced pancreas size. pancreata had almost no expression of the islet hormones genes, except for PP (polypeptide- producing). Belongs to the RFX family. Sequence=AAI32105.1; Type=Erroneous initiation; Evidence=; Sequence=AAI32295.1; Type=Erroneous initiation; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding type B pancreatic cell differentiation pancreatic A cell differentiation pancreatic D cell differentiation DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleolus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development cell differentiation endocrine pancreas development positive regulation of insulin secretion involved in cellular response to glucose stimulus glucose homeostasis transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of insulin secretion pancreatic epsilon cell differentiation uc011xdr.1 uc011xdr.2 uc011xdr.3 
ENSMUST00000122923.2 C630043F03Rik ENSMUST00000122923.2 C630043F03Rik (from geneSymbol) AK042990 ENSMUST00000122923.1 uc290nhd.1 uc290nhd.2 uc290nhd.1 uc290nhd.2 
ENSMUST00000122926.2 4930470G03Rik ENSMUST00000122926.2 RIKEN cDNA 4930470G03 gene (from RefSeq NR_151504.1) ENSMUST00000122926.1 NR_151504 uc288ler.1 uc288ler.2 uc288ler.1 uc288ler.2 
ENSMUST00000122940.2 4930586N03Rik ENSMUST00000122940.2 RIKEN cDNA 4930586N03 gene (from RefSeq NR_131052.1) ENSMUST00000122940.1 NR_131052 uc056ytf.1 uc056ytf.2 uc056ytf.1 uc056ytf.2 
ENSMUST00000122941.8 Zfr ENSMUST00000122941.8 zinc finger RNA binding protein, transcript variant 1 (from RefSeq NM_011767.2) ENSMUST00000122941.1 ENSMUST00000122941.2 ENSMUST00000122941.3 ENSMUST00000122941.4 ENSMUST00000122941.5 ENSMUST00000122941.6 ENSMUST00000122941.7 NM_011767 O88532 Q3TY30 Q8BS85 Q8CGG5 Q91VZ0 Q9CT34 ZFR_MOUSE uc007vhk.1 uc007vhk.2 uc007vhk.3 uc007vhk.4 uc007vhk.5 Involved in postimplantation and gastrulation stages of development. Binds to DNA and RNA. Involved in the nucleocytoplasmic shuttling of STAU2 (By similarity). Found in a cytoplasmic mRNP complex with STAU2. Does not interact with STAU1 (By similarity). Interacts with STAU2. Nucleus. Cytoplasm. Cytoplasmic granule Chromosome Note=Associated with chromosome foci in meiotic cells. Localizes in somatodendritic compartment of primary hippocampal neurons (By similarity). Colocalizes with STAU2 in several cytosolic RNA granules (By similarity). Associated with chromosomes. Expressed in Sertoli cells, spermatocytes, primary and growing oocytes and granulosa cells (at protein level). Expressed in testis, ovary and brain. Expressed in embryos at 5.5, 6.5 and 7 dpc (at protein level). Expressed in the trophoectoderm cells and inner cell mass of blastocysts (at protein level). Knockout mice form mesoderm but are delayed in their development and fail to form normal anterior embryonic structures. They show both an increase in programmed cell death and a decrease in mitotic index, especially in the region of the distal tip of the embryonic ectoderm. They also show a reduction in apical vacuoles in the columnar visceral endoderm cells in the extraembryonic region. Knockout mice die by 8 to 9 days of gestation. Sequence=AAC25762.1; Type=Erroneous initiation; Evidence=; Sequence=AAH06962.1; Type=Erroneous initiation; Evidence=; Sequence=AAH38599.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH38599.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH58570.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH58570.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC28897.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding RNA binding double-stranded RNA binding single-stranded RNA binding nucleus chromosome cytoplasm multicellular organism development zinc ion binding uc007vhk.1 uc007vhk.2 uc007vhk.3 uc007vhk.4 uc007vhk.5 
ENSMUST00000122963.2 4933427G23Rik ENSMUST00000122963.2 4933427G23Rik (from geneSymbol) AK030236 ENSMUST00000122963.1 uc008wqr.1 uc008wqr.2 uc008wqr.1 uc008wqr.2 
ENSMUST00000122965.8 Elp4 ENSMUST00000122965.8 elongator acetyltransferase complex subunit 4 (from RefSeq NM_023876.4) ELP4_MOUSE ENSMUST00000122965.1 ENSMUST00000122965.2 ENSMUST00000122965.3 ENSMUST00000122965.4 ENSMUST00000122965.5 ENSMUST00000122965.6 ENSMUST00000122965.7 NM_023876 Paxneb Q8BGM1 Q8BVB1 Q8BZN8 Q9CTR2 Q9ER73 uc008lld.1 uc008lld.2 uc008lld.3 uc008lld.4 Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Component of the elongator complex which consists of ELP1, ELP2, ELP3, ELP4, ELP5 and ELP6. Cytoplasm Nucleus Expressed throughout the cerebellum. Belongs to the ELP4 family. The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification. RNA polymerase II core binding tRNA wobble uridine modification nucleus nucleoplasm cytoplasm regulation of transcription from RNA polymerase II promoter transcription elongation factor complex phosphorylase kinase regulator activity Elongator holoenzyme complex regulation of protein kinase activity uc008lld.1 uc008lld.2 uc008lld.3 uc008lld.4 
ENSMUST00000122969.2 Gm12946 ENSMUST00000122969.2 Gm12946 (from geneSymbol) ENSMUST00000122969.1 KY468018 uc290puy.1 uc290puy.2 uc290puy.1 uc290puy.2 
ENSMUST00000122978.2 Ptf1aos ENSMUST00000122978.2 pancreas specific transcription factor 1a, opposite strand (from RefSeq NR_131924.1) ENSMUST00000122978.1 NR_131924 uc008img.1 uc008img.2 uc008img.1 uc008img.2 
ENSMUST00000122987.2 Gm16364 ENSMUST00000122987.2 Gm16364 (from geneSymbol) ENSMUST00000122987.1 KY467538 uc057kij.1 uc057kij.2 uc057kij.1 uc057kij.2 
ENSMUST00000122988.4 Gm2800 ENSMUST00000122988.4 predicted gene 2800 (from RefSeq NR_188991.1) ENSMUST00000122988.1 ENSMUST00000122988.2 ENSMUST00000122988.3 NR_188991 uc288jan.1 uc288jan.2 uc288jan.3 uc288jan.4 uc288jan.1 uc288jan.2 uc288jan.3 uc288jan.4 
ENSMUST00000122990.3 Dlx1as ENSMUST00000122990.3 Dlx1as (from geneSymbol) AK139461 ENSMUST00000122990.1 ENSMUST00000122990.2 uc289wva.1 uc289wva.2 uc289wva.3 uc289wva.1 uc289wva.2 uc289wva.3 
ENSMUST00000123087.10 Sp3os ENSMUST00000123087.10 Sp3os (from geneSymbol) AK005870 ENSMUST00000123087.1 ENSMUST00000123087.2 ENSMUST00000123087.3 ENSMUST00000123087.4 ENSMUST00000123087.5 ENSMUST00000123087.6 ENSMUST00000123087.7 ENSMUST00000123087.8 ENSMUST00000123087.9 uc008kce.1 uc008kce.2 uc008kce.3 uc008kce.4 uc008kce.5 uc008kce.6 uc008kce.1 uc008kce.2 uc008kce.3 uc008kce.4 uc008kce.5 uc008kce.6 
ENSMUST00000123117.2 Gm21984 ENSMUST00000123117.2 Gm21984 (from geneSymbol) BC011475 ENSMUST00000123117.1 uc291vqo.1 uc291vqo.2 uc291vqo.1 uc291vqo.2 
ENSMUST00000123120.2 Gm6787 ENSMUST00000123120.2 predicted gene 6787 (from RefSeq NR_003632.2) ENSMUST00000123120.1 NR_003632 uc009snt.1 uc009snt.2 uc009snt.1 uc009snt.2 
ENSMUST00000123121.9 Dusp15 ENSMUST00000123121.9 dual specificity phosphatase-like 15, transcript variant 1 (from RefSeq NM_001159376.1) A2APC1 DUS15_MOUSE Dusp15 ENSMUST00000123121.1 ENSMUST00000123121.2 ENSMUST00000123121.3 ENSMUST00000123121.4 ENSMUST00000123121.5 ENSMUST00000123121.6 ENSMUST00000123121.7 ENSMUST00000123121.8 NM_001159376 Q14AH2 Q8R4V2 uc012cgl.1 uc012cgl.2 uc012cgl.3 May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (By similarity). [Isoform 1]: May play a role in the regulation of oligodendrocyte differentiation (PubMed:22792334). May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Cell membrane ; Lipid-anchor; Cytoplasmic side. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R4V2-1; Sequence=Displayed; Name=2; IsoId=Q8R4V2-2; Sequence=VSP_007294, VSP_007295; Isoform 1 is expressed in testis; predominantly in developing spermatocytes (at protein level) (PubMed:15138252). Isoform 2 is highly expressed in testis (PubMed:11432789). Expressed in spinal cord and specifically in oligodendroglial cells (PubMed:27532821). Expressed in embryonic brain cortex; down-regulated in mice with experimental autoimmune encephalomyelitis (EAE) (PubMed:22792334). Expression increases during oligodendrocyte differentiation. Detected in spinal cord in late fetal (18.5 dpc) and early postnatal (P3 and P7) stages. Expression decreases in later postnatal development (P14 and P30). Down-regulated by nerve injury. [Isoform 2]: Inactive. Lacks the active site. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. Sequence=BU924460; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytosol plasma membrane protein dephosphorylation transforming growth factor beta receptor signaling pathway protein tyrosine/serine/threonine phosphatase activity membrane dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation regulation of cell proliferation positive regulation of JNK cascade regulation of oligodendrocyte differentiation positive regulation of ERK1 and ERK2 cascade uc012cgl.1 uc012cgl.2 uc012cgl.3 
ENSMUST00000123136.2 Astx4d ENSMUST00000123136.2 Astx4d (from geneSymbol) DQ874390 ENSMUST00000123136.1 uc292qju.1 uc292qju.2 uc292qju.1 uc292qju.2 
ENSMUST00000123160.3 Gm12037 ENSMUST00000123160.3 Gm12037 (from geneSymbol) ENSMUST00000123160.1 ENSMUST00000123160.2 KY467572 uc287wvw.1 uc287wvw.2 uc287wvw.3 uc287wvw.1 uc287wvw.2 uc287wvw.3 
ENSMUST00000123179.2 Larp7-ps ENSMUST00000123179.2 Nucleus (from UniProt A2AMD0) A2AMD0 A2AMD0_MOUSE ENSMUST00000123179.1 Gm12666 Larp7-ps uc290ntq.1 uc290ntq.2 Nucleus molecular_function nucleic acid binding RNA binding cellular_component biological_process uc290ntq.1 uc290ntq.2 
ENSMUST00000123231.3 Gm15584 ENSMUST00000123231.3 Gm15584 (from geneSymbol) ENSMUST00000123231.1 ENSMUST00000123231.2 uc287mjt.1 uc287mjt.2 uc287mjt.1 uc287mjt.2 
ENSMUST00000123249.3 4930417O22Rik ENSMUST00000123249.3 RIKEN cDNA 4930417O22 gene (from RefSeq NR_045806.1) ENSMUST00000123249.1 ENSMUST00000123249.2 NR_045806 uc007lpy.1 uc007lpy.2 uc007lpy.3 uc007lpy.4 uc007lpy.5 uc007lpy.1 uc007lpy.2 uc007lpy.3 uc007lpy.4 uc007lpy.5 
ENSMUST00000123258.2 Gm12702 ENSMUST00000123258.2 Gm12702 (from geneSymbol) ENSMUST00000123258.1 uc290oax.1 uc290oax.2 uc290oax.1 uc290oax.2 
ENSMUST00000123278.2 Gm12127 ENSMUST00000123278.2 Gm12127 (from geneSymbol) ENSMUST00000123278.1 uc287xko.1 uc287xko.2 uc287xko.1 uc287xko.2 
ENSMUST00000123285.2 Nyap2 ENSMUST00000123285.2 neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2, transcript variant 1 (from RefSeq NM_001356397.1) A0A0R4J1X0 A0A0R4J1X0_MOUSE ENSMUST00000123285.1 NM_001356397 Nyap2 uc287jrl.1 uc287jrl.2 phosphatidylinositol 3-kinase signaling neuron projection morphogenesis uc287jrl.1 uc287jrl.2 
ENSMUST00000123318.2 Gm15965 ENSMUST00000123318.2 Gm15965 (from geneSymbol) ENSMUST00000123318.1 KY467760 uc057kvv.1 uc057kvv.2 uc057kvv.1 uc057kvv.2 
ENSMUST00000123363.3 Gm16014 ENSMUST00000123363.3 Gm16014 (from geneSymbol) ENSMUST00000123363.1 ENSMUST00000123363.2 KY468041 uc057lmb.1 uc057lmb.2 uc057lmb.3 uc057lmb.1 uc057lmb.2 uc057lmb.3 
ENSMUST00000123377.3 4930533B01Rik ENSMUST00000123377.3 RIKEN cDNA 4930533B01 gene (from RefSeq NR_040614.1) ENSMUST00000123377.1 ENSMUST00000123377.2 NR_040614 uc029uea.1 uc029uea.2 uc029uea.3 uc029uea.1 uc029uea.2 uc029uea.3 
ENSMUST00000123402.2 Vax2os ENSMUST00000123402.2 ventral anterior homeobox 2, opposite strand, transcript variant 2 (from RefSeq NR_002871.2) ENSMUST00000123402.1 NR_002871 uc009cnx.1 uc009cnx.2 uc009cnx.1 uc009cnx.2 
ENSMUST00000123420.2 B430319H21Rik ENSMUST00000123420.2 B430319H21Rik (from geneSymbol) AK021026 ENSMUST00000123420.1 uc287yyn.1 uc287yyn.2 uc287yyn.1 uc287yyn.2 
ENSMUST00000123434.3 Pirt ENSMUST00000123434.3 phosphoinositide-interacting regulator of transient receptor potential channels (from RefSeq NM_178656.3) ENSMUST00000123434.1 ENSMUST00000123434.2 NM_178656 PIRT_MOUSE Q8BFY0 uc007jln.1 uc007jln.2 uc007jln.3 Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI). Interacts with TRPV1. Membrane ; Multi-pass membrane protein Strongly expressed in most dorsal root ganglia (DRG) and trigeminal neurons. Expressed by most peptidergic (CGRP+) and non-peptidergic (IB4+) DRG neurons. Weakly expressed in other parts of the peripheral nervous system (PNS) including sympathetic and enteric neurons. Not expressed in the spinal cord. First expressed in DRG neurons around embryonic day 11.5, and expression is maintained throughout adulthood. Mice show impaired responsiveness to noxious heat and capsaicin. Noxious heat- and capsaicin-sensitive currents in DRG neurons are significantly attenuated. phosphatidylinositol-3,4,5-trisphosphate binding plasma membrane response to heat membrane integral component of membrane ion channel binding phosphatidylinositol-mediated signaling behavioral response to pain phosphatidylinositol bisphosphate binding positive regulation of cation channel activity uc007jln.1 uc007jln.2 uc007jln.3 
ENSMUST00000123441.2 Gm13954 ENSMUST00000123441.2 Gm13954 (from geneSymbol) ENSMUST00000123441.1 uc289zav.1 uc289zav.2 uc289zav.1 uc289zav.2 
ENSMUST00000123453.2 Gmip ENSMUST00000123453.2 Stimulates, in vitro and in vivo, the GTPase activity of RhoA. (from UniProt Q6PGG2) BC060628 ENSMUST00000123453.1 GMIP_MOUSE Q6P9S3 Q6PGG2 uc009lxs.1 uc009lxs.2 uc009lxs.3 Stimulates, in vitro and in vivo, the GTPase activity of RhoA. Interacts with GEM through its N-terminal. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PGG2-1; Sequence=Displayed; Name=2; IsoId=Q6PGG2-2; Sequence=VSP_013190, VSP_013191; GTPase activator activity nucleoplasm cytosol plasma membrane signal transduction negative regulation of GTPase activity intracellular signal transduction positive regulation of GTPase activity metal ion binding uc009lxs.1 uc009lxs.2 uc009lxs.3 
ENSMUST00000123459.2 Gm11946 ENSMUST00000123459.2 Gm11946 (from geneSymbol) AK035589 ENSMUST00000123459.1 uc287wem.1 uc287wem.2 uc287wem.1 uc287wem.2 
ENSMUST00000123460.2 Zfp986 ENSMUST00000123460.2 Zfp986 (from geneSymbol) BC086318 ENSMUST00000123460.1 L7MUC9 L7MUC9_MOUSE Zfp986 uc290rpw.1 uc290rpw.2 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc290rpw.1 uc290rpw.2 
ENSMUST00000123491.8 Dnal1 ENSMUST00000123491.8 dynein, axonemal, light chain 1, transcript variant 1 (from RefSeq NM_028821.3) A0JLX1 DNAL1_MOUSE Dnalc1 ENSMUST00000123491.1 ENSMUST00000123491.2 ENSMUST00000123491.3 ENSMUST00000123491.4 ENSMUST00000123491.5 ENSMUST00000123491.6 ENSMUST00000123491.7 NM_028821 Q05A62 Q9DAH9 uc011yos.1 uc011yos.2 uc011yos.3 uc011yos.4 Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (By similarity). Interacts with ZMYND10 (via C-terminus). Interacts with DNAH5, a outer arm dynein heavy chain. Interacts with tubulin located within the A-tubule of the outer doublets in a ATP-independent manner. Cytoplasm, cytoskeleton, cilium axoneme Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q05A62-1; Sequence=Displayed; Name=2; IsoId=Q05A62-2; Sequence=VSP_023984, VSP_023983; Name=3; IsoId=Q05A62-3; Sequence=VSP_023985; Expressed in the respiratory epithelium of the upper airways and the ependymal cells lining the brain ventricles. Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms. Belongs to the dynein light chain LC1-type family. Sequence=AAI25395.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; motor activity cytoplasm cytoskeleton microtubule dynein complex outer dynein arm outer dynein arm assembly cell projection alpha-tubulin binding dynein heavy chain binding uc011yos.1 uc011yos.2 uc011yos.3 uc011yos.4 
ENSMUST00000123498.8 Mipol1 ENSMUST00000123498.8 mirror-image polydactyly 1, transcript variant 4 (from RefSeq NM_001422494.1) ENSMUST00000123498.1 ENSMUST00000123498.2 ENSMUST00000123498.3 ENSMUST00000123498.4 ENSMUST00000123498.5 ENSMUST00000123498.6 ENSMUST00000123498.7 G3UVV8 G3UVV8_MOUSE Mipol1 NM_001422494 uc288gne.1 uc288gne.2 uc288gne.1 uc288gne.2 
ENSMUST00000123506.9 Mtmr3 ENSMUST00000123506.9 myotubularin related protein 3, transcript variant 1 (from RefSeq NM_001373897.1) ENSMUST00000123506.1 ENSMUST00000123506.2 ENSMUST00000123506.3 ENSMUST00000123506.4 ENSMUST00000123506.5 ENSMUST00000123506.6 ENSMUST00000123506.7 ENSMUST00000123506.8 Mtmr3 NM_001373897 R4GML8 R4GML8_MOUSE uc287whr.1 uc287whr.2 uc287whr.3 Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3- phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:42328, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:65221, ChEBI:CHEBI:78934; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3- phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64; Evidence=; Cytoplasm Membrane ; Peripheral membrane protein Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. protein tyrosine phosphatase activity dephosphorylation peptidyl-tyrosine dephosphorylation metal ion binding uc287whr.1 uc287whr.2 uc287whr.3 
ENSMUST00000123508.2 Astx3 ENSMUST00000123508.2 Astx3 (from geneSymbol) DQ874390 ENSMUST00000123508.1 uc292qjx.1 uc292qjx.2 uc292qjx.1 uc292qjx.2 
ENSMUST00000123514.8 Tnfrsf14 ENSMUST00000123514.8 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) (from RefSeq NM_178931.2) ENSMUST00000123514.1 ENSMUST00000123514.2 ENSMUST00000123514.3 ENSMUST00000123514.4 ENSMUST00000123514.5 ENSMUST00000123514.6 ENSMUST00000123514.7 NM_178931 Q80WM9 TNR14_MOUSE Tnfrsf14 hvem uc008wcj.1 uc008wcj.2 uc008wcj.3 Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (By similarity). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (By similarity). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:25711213). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (PubMed:22801499). Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (By similarity). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044, PubMed:15568026). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044, PubMed:15568026). Interacts with TRAF2, TRAF3 and TRAF5 (By similarity). Interacts (via CRD1/TNFR-Cys 1) with CD160; this interaction is direct (PubMed:18193050). Interacts (via CRD1/TNFR-Cys 1) with BTLA; this interaction is direct (PubMed:15568026). Cell membrane ; Single-pass type I membrane protein Expressed at mucosal sites including colon and pulmonary epithelial cells (PubMed:22801499). Expressed in naive T cells (PubMed:19915044). The cysteine rich domain I (CRD1/TNFR-Cys 1) is required for interaction with CD160 and BTLA. N-glycosylated. Belongs to the tumor necrosis factor receptor superfamily. virus receptor activity adaptive immune response immune system process positive regulation of cytokine secretion involved in immune response protein binding plasma membrane external side of plasma membrane membrane integral component of membrane viral process cytokine binding T cell costimulation ubiquitin protein ligase binding innate immune response negative regulation of alpha-beta T cell proliferation viral entry into host cell positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium defense response to Gram-positive bacterium negative regulation of adaptive immune memory response positive regulation of T cell migration uc008wcj.1 uc008wcj.2 uc008wcj.3 
ENSMUST00000123548.2 Gm13205 ENSMUST00000123548.2 predicted gene 13205 (from RefSeq NR_154553.1) ENSMUST00000123548.1 NR_154553 uc290rwr.1 uc290rwr.2 uc290rwr.1 uc290rwr.2 
ENSMUST00000123574.2 Gm14002 ENSMUST00000123574.2 Gm14002 (from geneSymbol) ENSMUST00000123574.1 KY467892 uc057ldy.1 uc057ldy.2 uc057ldy.1 uc057ldy.2 
ENSMUST00000123605.9 Dhodh ENSMUST00000123605.9 dihydroorotate dehydrogenase (from RefSeq NM_020046.3) ENSMUST00000123605.1 ENSMUST00000123605.2 ENSMUST00000123605.3 ENSMUST00000123605.4 ENSMUST00000123605.5 ENSMUST00000123605.6 ENSMUST00000123605.7 ENSMUST00000123605.8 NM_020046 O35435 PYRD_MOUSE uc009nip.1 uc009nip.2 uc009nip.3 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway. Reaction=(S)-dihydroorotate + a quinone = a quinol + orotate; Xref=Rhea:RHEA:30187, ChEBI:CHEBI:24646, ChEBI:CHEBI:30839, ChEBI:CHEBI:30864, ChEBI:CHEBI:132124; EC=1.3.5.2; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Note=Binds 1 FMN per subunit. ; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. Monomer. Mitochondrion inner membrane ; Single-pass membrane protein The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration. Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. catalytic activity dihydroorotate dehydrogenase activity nucleoplasm cytoplasm mitochondrion mitochondrial inner membrane cytosol 'de novo' pyrimidine nucleobase biosynthetic process pyrimidine nucleotide biosynthetic process female pregnancy lactation drug binding pyrimidine ribonucleotide biosynthetic process FMN binding response to organic cyclic compound membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors response to caffeine response to drug response to starvation neuronal cell body positive regulation of apoptotic process 'de novo' UMP biosynthetic process ubiquinone binding oxidation-reduction process regulation of mitochondrial fission response to L-arginine uc009nip.1 uc009nip.2 uc009nip.3 
ENSMUST00000123606.2 Gm12670 ENSMUST00000123606.2 Gm12670 (from geneSymbol) ENSMUST00000123606.1 uc290ntm.1 uc290ntm.2 uc290ntm.1 uc290ntm.2 
ENSMUST00000123610.2 Prkag2os2 ENSMUST00000123610.2 Prkag2os2 (from geneSymbol) AK087879 ENSMUST00000123610.1 uc290ttk.1 uc290ttk.2 uc290ttk.1 uc290ttk.2 
ENSMUST00000123613.2 Chn1os1 ENSMUST00000123613.2 Chn1os1 (from geneSymbol) ENSMUST00000123613.1 uc289wyt.1 uc289wyt.2 uc289wyt.1 uc289wyt.2 
ENSMUST00000123614.8 Ptgr2 ENSMUST00000123614.8 prostaglandin reductase 2, transcript variant 1 (from RefSeq NM_029880.3) ENSMUST00000123614.1 ENSMUST00000123614.2 ENSMUST00000123614.3 ENSMUST00000123614.4 ENSMUST00000123614.5 ENSMUST00000123614.6 ENSMUST00000123614.7 NM_029880 PTGR2_MOUSE Ptgr2 Q3TG36 Q3ULY3 Q8BZA2 Q8VDQ1 Q9D1W8 Zadh1 uc007oeq.1 uc007oeq.2 uc007oeq.3 uc007oeq.4 Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Reaction=13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15- oxoprostaglandin E2 + H(+) + NADH; Xref=Rhea:RHEA:11916, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57402, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.48; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:11918; Evidence=; Reaction=13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15- oxoprostaglandin E2 + H(+) + NADPH; Xref=Rhea:RHEA:11912, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57402, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.48; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:11914; Evidence=; Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374, ChEBI:CHEBI:133409; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50590; Evidence=; Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15- oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584, ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133408; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50586; Evidence=; Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15- oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:79072, ChEBI:CHEBI:133411; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50594; Evidence=; Kinetic parameters: KM=49.6 uM for 15-keto-PGE2 ; KM=34.4 uM for 15-keto-PGE1 ; KM=108.8 uM for 15-keto-PGF2-alpha ; KM=59.2 uM for 15-keto-PGF2-beta ; KM=94.6 uM for NADPH ; Vmax=178.4 umol/min/mg enzyme for 15-keto-PGE2 ; Vmax=115.0 umol/min/mg enzyme for 15-keto-PGE1 ; Vmax=230.9 umol/min/mg enzyme for 15-keto-PGF2-alpha ; Vmax=206.4 umol/min/mg enzyme for 15-keto-PGF2-beta ; Vmax=144.7 umol/min/mg enzyme for NADPH ; Monomer. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VDQ1-1; Sequence=Displayed; Name=2; IsoId=Q8VDQ1-2; Sequence=VSP_013528, VSP_013529; Widely expressed with highest levels in adipose tissues. Highly expressed in the late phase of adipocyte differentiation (at protein level). Belongs to the NADP-dependent oxidoreductase L4BD family. cytoplasm mitochondrion cytosol prostaglandin metabolic process oxidoreductase activity 13-prostaglandin reductase activity 15-oxoprostaglandin 13-oxidase activity oxidation-reduction process zinc ion binding uc007oeq.1 uc007oeq.2 uc007oeq.3 uc007oeq.4 
ENSMUST00000123644.3 Gm15510 ENSMUST00000123644.3 predicted gene 15510 (from RefSeq NR_166619.1) ENSMUST00000123644.1 ENSMUST00000123644.2 NR_166619 uc009ezo.1 uc009ezo.2 uc009ezo.1 uc009ezo.2 
ENSMUST00000123680.2 Pigyl ENSMUST00000123680.2 phosphatidylinositol glycan anchor biosynthesis, class Y-like (from RefSeq NM_001082532.1) ENSMUST00000123680.1 NM_001082532 P0C1P0 PIGY_MOUSE Pigy uc009ooc.1 uc009ooc.2 uc009ooc.3 uc009ooc.4 This gene encodes a homolog of a human protein that functions in glycosylphosphatidylinositol biosynthesis. The human protein is expressed from an unusual locus that encodes two distinct proteins in upstream and downstream CDSes; however, in mouse these two proteins are expressed from distinct loci. The product of this locus is highly similar to the protein expressed from the human downstream CDS. A separate mouse locus on chromosome 6 is orthologous to the human locus and encodes a protein similar to the human protein expressed from the upstream CDS. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: BU525483.1, BU558514.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Part of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the catalytic subunit PIGA. Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Component of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts directly with PIGA; this interaction regulates glycosylphosphatidylinositol-N- acetylglucosaminyltransferase activity. Does not interact with Ras proteins. Endoplasmic reticulum membrane ; Multi-pass membrane protein glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process membrane integral component of membrane phosphatidylinositol N-acetylglucosaminyltransferase activity uc009ooc.1 uc009ooc.2 uc009ooc.3 uc009ooc.4 
ENSMUST00000123703.2 B430010I23Rik ENSMUST00000123703.2 RIKEN cDNA B430010I23 gene (from RefSeq NR_015457.2) ENSMUST00000123703.1 NR_015457 uc057lxa.1 uc057lxa.2 uc057lxa.1 uc057lxa.2 
ENSMUST00000123707.2 Gm16189 ENSMUST00000123707.2 Gm16189 (from geneSymbol) AK142539 ENSMUST00000123707.1 uc292oom.1 uc292oom.2 uc292oom.1 uc292oom.2 
ENSMUST00000123708.8 Ifi203 ENSMUST00000123708.8 interferon activated gene 203, transcript variant 3 (from RefSeq NM_001302651.1) E9PUG6 E9PUG6_MOUSE ENSMUST00000123708.1 ENSMUST00000123708.2 ENSMUST00000123708.3 ENSMUST00000123708.4 ENSMUST00000123708.5 ENSMUST00000123708.6 ENSMUST00000123708.7 Ifi203 NM_001302651 uc007dsh.1 uc007dsh.2 uc007dsh.3 uc007dsh.4 uc007dsh.5 Belongs to the HIN-200 family. activation of innate immune response cellular response to interferon-beta uc007dsh.1 uc007dsh.2 uc007dsh.3 uc007dsh.4 uc007dsh.5 
ENSMUST00000123764.2 Gm12660 ENSMUST00000123764.2 Gm12660 (from geneSymbol) ENSMUST00000123764.1 uc287xxm.1 uc287xxm.2 uc287xxm.1 uc287xxm.2 
ENSMUST00000123784.2 Gm11629 ENSMUST00000123784.2 Gm11629 (from geneSymbol) ENSMUST00000123784.1 uc288bww.1 uc288bww.2 uc288bww.1 uc288bww.2 
ENSMUST00000123812.3 Arhgap27os2 ENSMUST00000123812.3 Arhgap27os2 (from geneSymbol) AK052773 ENSMUST00000123812.1 ENSMUST00000123812.2 uc007lue.1 uc007lue.2 uc007lue.3 uc007lue.1 uc007lue.2 uc007lue.3 
ENSMUST00000123818.2 Oip5 ENSMUST00000123818.2 Opa interacting protein 5 (from RefSeq NM_001042653.1) A2AQ14 ENSMUST00000123818.1 MS18B_MOUSE Ms18b NM_001042653 Q14AW4 Q14BH1 uc008ltz.1 uc008ltz.2 uc008ltz.3 Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. Homodimer, and heterodimer with MIS18A. Identified in a complex containing MIS18A, OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4. Nucleus Chromosome Chromosome, centromere Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin. Belongs to the mis18 family. Sequence=AAI16661.1; Type=Erroneous initiation; Evidence=; chromosome, centromeric region chromatin nucleus nucleoplasm chromosome cytosol cell cycle chromosome segregation chromocenter Cajal body nuclear speck CENP-A containing nucleosome assembly identical protein binding metal ion binding cell division uc008ltz.1 uc008ltz.2 uc008ltz.3 
ENSMUST00000123836.2 Uxt ENSMUST00000123836.2 ubiquitously expressed prefoldin like chaperone, transcript variant 1 (from RefSeq NM_013840.4) ENSMUST00000123836.1 NM_013840 Q8CEJ2 Q9WTZ0 UXT_MOUSE uc009sue.1 uc009sue.2 uc009sue.3 Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. [Isoform 1]: Plays a role in protecting cells against TNF- alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP. Homohexamer (By similarity). Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92 (By similarity). Interacts with LRPPRC (By similarity). Interacts with androgen receptor AR (via N- terminus) (By similarity). Interacts with estrogen receptor ESR1; the interaction relocalizes ESR1 to the cytoplasm (By similarity). In the nucleus, interacts specifically with RELA (via RHD domain) and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation (By similarity). Interacts with MECOM (By similarity). Interacts with URI1 (By similarity). [Isoform 1]: Part of complex I composed of TNF-alpha receptor, TRADD, TRAF2 and RIPK1 (By similarity). Within the complex, interacts (via TPQE motif) with TRAF2; the interaction prevents the recruitment of FADD and CASP8/caspase 8 to complex I (PubMed:21307340). [Isoform 1]: Cytoplasm Cytoplasm Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Note=Predominantly localizes to the nucleus. Localizes to spindle pole during mitosis. Event=Alternative splicing; Named isoforms=2; Name=2; Synonyms=UXT-V2 ; IsoId=Q9WTZ0-1; Sequence=Displayed; Name=1; Synonyms=UXT-V1 ; IsoId=Q9WTZ0-2; Sequence=Not described; [Isoform 1]: No initiation Met is found in the EST sequence upstream the Met for isoform 1. Belongs to the UXT family. negative regulation of transcription from RNA polymerase II promoter microtubule cytoskeleton organization chromatin spindle pole gamma-tubulin complex chromatin binding transcription cofactor activity transcription corepressor activity nucleus cytoplasm centrosome microtubule organizing center cytoskeleton apoptotic process centrosome cycle beta-tubulin binding uc009sue.1 uc009sue.2 uc009sue.3 
ENSMUST00000123840.3 2900072N19Rik ENSMUST00000123840.3 2900072N19Rik (from geneSymbol) AK013769 ENSMUST00000123840.1 ENSMUST00000123840.2 uc289yms.1 uc289yms.2 uc289yms.3 uc289yms.1 uc289yms.2 uc289yms.3 
ENSMUST00000123853.9 Akap11 ENSMUST00000123853.9 A kinase anchor protein 11, transcript variant 2 (from RefSeq NM_001346784.1) Akap11 E9Q777 E9Q777_MOUSE ENSMUST00000123853.1 ENSMUST00000123853.2 ENSMUST00000123853.3 ENSMUST00000123853.4 ENSMUST00000123853.5 ENSMUST00000123853.6 ENSMUST00000123853.7 ENSMUST00000123853.8 NM_001346784 uc007usi.1 uc007usi.2 uc007usi.3 uc007usi.4 positive regulation of protein phosphorylation nucleolus cytoplasm peroxisome cytosol plasma membrane protein localization protein phosphatase 1 binding kinase regulator activity macromolecular complex protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding regulation of kinase activity protein kinase A binding positive regulation of establishment of endothelial barrier uc007usi.1 uc007usi.2 uc007usi.3 uc007usi.4 
ENSMUST00000123882.2 Gm16045 ENSMUST00000123882.2 Gm16045 (from geneSymbol) ENSMUST00000123882.1 uc288dwl.1 uc288dwl.2 uc288dwl.1 uc288dwl.2 
ENSMUST00000123899.3 Gm12679 ENSMUST00000123899.3 Gm12679 (from geneSymbol) ENSMUST00000123899.1 ENSMUST00000123899.2 KY467976 uc290mkt.1 uc290mkt.2 uc290mkt.3 uc290mkt.1 uc290mkt.2 uc290mkt.3 
ENSMUST00000123905.2 Gm15742 ENSMUST00000123905.2 Gm15742 (from geneSymbol) ENSMUST00000123905.1 uc289dze.1 uc289dze.2 uc289dze.1 uc289dze.2 
ENSMUST00000123920.3 Gm15351 ENSMUST00000123920.3 Gm15351 (from geneSymbol) ENSMUST00000123920.1 ENSMUST00000123920.2 KY468177 uc057lwi.1 uc057lwi.2 uc057lwi.3 uc057lwi.1 uc057lwi.2 uc057lwi.3 
ENSMUST00000123933.8 Gm12446 ENSMUST00000123933.8 predicted gene 12446 (from RefSeq NR_165272.1) ENSMUST00000123933.1 ENSMUST00000123933.2 ENSMUST00000123933.3 ENSMUST00000123933.4 ENSMUST00000123933.5 ENSMUST00000123933.6 ENSMUST00000123933.7 NR_165272 uc290mnw.1 uc290mnw.2 uc290mnw.1 uc290mnw.2 
ENSMUST00000123949.2 Gm12264 ENSMUST00000123949.2 Gm12264 (from geneSymbol) AK015965 ENSMUST00000123949.1 uc287ynu.1 uc287ynu.2 uc287ynu.1 uc287ynu.2 
ENSMUST00000123952.9 Cfap74 ENSMUST00000123952.9 cilia and flagella associated protein 74, transcript variant 2 (from RefSeq NM_001166029.1) Cfap74 ENSMUST00000123952.1 ENSMUST00000123952.2 ENSMUST00000123952.3 ENSMUST00000123952.4 ENSMUST00000123952.5 ENSMUST00000123952.6 ENSMUST00000123952.7 ENSMUST00000123952.8 G3UWF6 G3UWF6_MOUSE NM_001166029 uc008wdj.1 uc008wdj.2 uc008wdj.3 uc008wdj.4 uc008wdj.1 uc008wdj.2 uc008wdj.3 uc008wdj.4 
ENSMUST00000124021.3 Or4c104 ENSMUST00000124021.3 olfactory receptor family 4 subfamily C member 104, transcript variant 1 (from RefSeq NM_146458.2) ENSMUST00000124021.1 ENSMUST00000124021.2 NM_146458 Olfr1199 Olfr1209 Or4c104 Q8VF94 Q8VF94_MOUSE uc289xzl.1 uc289xzl.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: CB173427.1 [ECO:0000332] ##Evidence-Data-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xzl.1 uc289xzl.2 
ENSMUST00000124051.10 Optc ENSMUST00000124051.10 opticin, transcript variant 1 (from RefSeq NM_054076.4) ENSMUST00000124051.1 ENSMUST00000124051.2 ENSMUST00000124051.3 ENSMUST00000124051.4 ENSMUST00000124051.5 ENSMUST00000124051.6 ENSMUST00000124051.7 ENSMUST00000124051.8 ENSMUST00000124051.9 NM_054076 OPT_MOUSE Opt Q8K3K2 Q91ZZ9 Q920A0 uc007cqy.1 uc007cqy.2 uc007cqy.3 uc007cqy.4 uc007cqy.5 uc007cqy.6 Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (PubMed:22159013). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (PubMed:29323130). Homodimer. Secreted, extracellular space, extracellular matrix Expressed in cartilage (at protein level) (PubMed:29323130). Expressed in the vitreous collagen, inner limiting membrane, lens capsule, trabecular meshwork, anterior surface of the iris, the area adjacent to the nonpigmented ciliary epithelium, and weakly expressed in the retina of the eye (at protein level) (PubMed:22159013). Expressed in the nonpigmented ciliary epithelium of the eye (PubMed:11527931). Expressed in the presumptive ciliary body during development. O-glycosylated. Sulfated on tyrosine residues. Proteolytically cleaved by MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, ADAMTS4, and ADAMTS5 (By similarity). Proteolytically cleaved by MMP13 (By similarity). Increased organization of cartilage collagen fibers featuring more smaller diameter fibers that are closely packed (PubMed:29323130). Dysregulation of small leucine-rich repeat proteoglycan superfamily members in cartilage, including an increase in Lum and Epyc, and a decrease in Fmod and Prelp (PubMed:29323130). In a surgical osteoarthritis model, a reduction in cartilage degradation and inflammatory markers, decreased loss of cartilage integrity, and reduced synovial membrane thickness (PubMed:29323130). Decrease in vitreous body vaso-obliteration upon hypoxia, and an increase in preretinal neovascularization upon restoration of normoxia (PubMed:22159013). Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. molecular_function extracellular region negative regulation of angiogenesis extracellular matrix uc007cqy.1 uc007cqy.2 uc007cqy.3 uc007cqy.4 uc007cqy.5 uc007cqy.6 
ENSMUST00000124055.2 Gm16249 ENSMUST00000124055.2 Gm16249 (from geneSymbol) AK135904 ENSMUST00000124055.1 uc007qpd.1 uc007qpd.2 uc007qpd.1 uc007qpd.2 
ENSMUST00000124065.2 Rad51ap2 ENSMUST00000124065.2 RAD51 associated protein 2 (from RefSeq NM_001111118.2) ENSMUST00000124065.1 G3UW63 G3UW63_MOUSE NM_001111118 Rad51ap2 uc011ykh.1 uc011ykh.2 molecular_function biological_process macromolecular complex uc011ykh.1 uc011ykh.2 
ENSMUST00000124071.9 Dmbx1 ENSMUST00000124071.9 diencephalon/mesencephalon homeobox 1, transcript variant 2 (from RefSeq NM_001025567.1) B1ASG1 Cdmx DMBX1_MOUSE Dmbx1 ENSMUST00000124071.1 ENSMUST00000124071.2 ENSMUST00000124071.3 ENSMUST00000124071.4 ENSMUST00000124071.5 ENSMUST00000124071.6 ENSMUST00000124071.7 ENSMUST00000124071.8 Mbx NM_001025567 Otx3 PaxB Q8CH43 Q8K4U6 Q8VHG8 Q91ZK3 Q91ZK4 uc008ufq.1 uc008ufq.2 Functions as a transcriptional repressor. May repress OTX2- mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability. Homodimer or heterodimer. Forms heterodimers with OTX2. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 IsoId=Q91ZK4-1; Sequence=Displayed; Name=2 IsoId=Q91ZK4-2; Sequence=VSP_052252; Expressed in adult brain, stomach, and testis. Expressed in the developing diencephalon, midbrain and hindbrain. During limb development, expressed in a temporal pattern with expression being first restricted to the forelimbs and then subsequently to the hindlimbs. Detected in embryo from 10.5 to 13.5 dpc. Strongly expressed from 9.5 to 11.5 dpc in the diencephalon, mesencephalon, metencephalon, myeloencephalon, and the developing eye. Belongs to the paired homeobox family. Sequence=BAC00919.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated multicellular organism development central nervous system development brain development adult feeding behavior adult locomotory behavior protein homodimerization activity sequence-specific DNA binding negative regulation of transcription, DNA-templated protein heterodimerization activity developmental growth uc008ufq.1 uc008ufq.2 
ENSMUST00000124093.3 Sycp2l ENSMUST00000124093.3 synaptonemal complex protein 2-like (from RefSeq NM_001324525.1) A0A0M3U1B0 D3YWV8 ENSMUST00000124093.1 ENSMUST00000124093.2 F6RWL8 F6ZC70 NM_001324525 SYC2L_MOUSE Sycp2l uc057bdd.1 uc057bdd.2 uc057bdd.3 uc057bdd.4 Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes. Nucleus Chromosome, centromere Note=Localized to the synaptonemal complex lateral elements in late diplotene oocytes, while it is absent on the synaptonemal complex of leptotene, zygotene, pachytene and early diplotene oocytes (PubMed:26362258). Localizes to centromeres in dictyate oocytes (PubMed:26362258). Detected in nuclear granules and sizable aggregates (By similarity). Specifically expressed in oocytes. Reduced fertility in females: acceleration of the age-associated decline of fertility in female mice, due to progressive loss of oocytes. Males are normal and fertile. Belongs to the SYCP2 family. chromosome, centromeric region condensed nuclear chromosome, centromeric region lateral element molecular_function nucleus nucleoplasm chromosome negative regulation of cell death uc057bdd.1 uc057bdd.2 uc057bdd.3 uc057bdd.4 
ENSMUST00000124095.3 4921508D12Rik ENSMUST00000124095.3 RIKEN cDNA 4921508D12 gene (from RefSeq NR_045802.1) ENSMUST00000124095.1 ENSMUST00000124095.2 NR_045802 uc029uev.1 uc029uev.2 uc029uev.3 uc029uev.1 uc029uev.2 uc029uev.3 
ENSMUST00000124118.9 Gm14965 ENSMUST00000124118.9 Gm14965 (from geneSymbol) ENSMUST00000124118.1 ENSMUST00000124118.2 ENSMUST00000124118.3 ENSMUST00000124118.4 ENSMUST00000124118.5 ENSMUST00000124118.6 ENSMUST00000124118.7 ENSMUST00000124118.8 uc289qnu.1 uc289qnu.2 uc289qnu.3 uc289qnu.1 uc289qnu.2 uc289qnu.3 
ENSMUST00000124153.2 Gm13781 ENSMUST00000124153.2 Gm13781 (from geneSymbol) ENSMUST00000124153.1 uc291dfe.1 uc291dfe.2 uc291dfe.1 uc291dfe.2 
ENSMUST00000124160.4 Gm15671 ENSMUST00000124160.4 Gm15671 (from geneSymbol) ENSMUST00000124160.1 ENSMUST00000124160.2 ENSMUST00000124160.3 uc287iyi.1 uc287iyi.2 uc287iyi.1 uc287iyi.2 
ENSMUST00000124182.2 Gm16217 ENSMUST00000124182.2 Gm16217 (from geneSymbol) ENSMUST00000124182.1 uc287vos.1 uc287vos.2 uc287vos.1 uc287vos.2 
ENSMUST00000124184.2 Gm15962 ENSMUST00000124184.2 Gm15962 (from geneSymbol) ENSMUST00000124184.1 uc289rdc.1 uc289rdc.2 uc289rdc.1 uc289rdc.2 
ENSMUST00000124187.8 Haus2 ENSMUST00000124187.8 HAUS augmin-like complex, subunit 2, transcript variant 1 (from RefSeq NM_025475.3) A2AKH8 A2AKI1 Cep27 ENSMUST00000124187.1 ENSMUST00000124187.2 ENSMUST00000124187.3 ENSMUST00000124187.4 ENSMUST00000124187.5 ENSMUST00000124187.6 ENSMUST00000124187.7 HAUS2_MOUSE NM_025475 Q3V1R1 Q9CQS9 Q9CRI2 Q9D9D0 uc008lwo.1 uc008lwo.2 uc008lwo.3 uc008lwo.4 uc008lwo.5 Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly (By similarity). Interacts with EML3 (phosphorylated at 'Thr-882') (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQS9-1; Sequence=Displayed; Name=2; IsoId=Q9CQS9-2; Sequence=VSP_012224; Belongs to the HAUS2 family. molecular_function cytoplasm centrosome microtubule organizing center spindle cytoskeleton microtubule spindle microtubule cell cycle centrosome cycle microtubule organizing center organization spindle assembly cell division HAUS complex uc008lwo.1 uc008lwo.2 uc008lwo.3 uc008lwo.4 uc008lwo.5 
ENSMUST00000124189.3 Trpc2 ENSMUST00000124189.3 transient receptor potential cation channel, subfamily C, member 2 (from RefSeq NM_001109897.2) ENSMUST00000124189.1 ENSMUST00000124189.2 NM_001109897 Q9ES59 Q9ES60 Q9R243 Q9R244 TRPC2_MOUSE Trp2 Trrp2 uc012fqs.1 uc012fqs.2 uc012fqs.3 uc012fqs.4 Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. May also be activated by intracellular calcium store depletion. Plays a role in mediating responsivity to pheromones that elicit aggressive and mating behaviors. Required for response to the Esp1 pheromone which enhances female sexual receptive behavior and to the Esp22 pheromone which inhibits adult male mating behavior. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=A; IsoId=Q9R244-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9R244-2; Sequence=VSP_006562; Name=3; Synonyms=Alpha; IsoId=Q9R244-3; Sequence=VSP_006564; Name=4; Synonyms=Beta; IsoId=Q9R244-4; Sequence=VSP_006563, VSP_006565; Isoform 3 is ubiquitously expressed at low levels. Isoform 4 is expressed exclusively in vomeronasal organ. Reduced electrophysiological response to pheromone mixtures in the vomeronasal organ. Mutant males and nursing females are docile and fail to initiate aggressive attacks on intruder males. Males display normal mating behavior towards females but display increased sexual behavior towards prepubescent females even when presented simultaneously with adult estrus females and also show increased sexual behavior towards juvenile and adult males. Lack of response to Esp1. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC2 sub-subfamily. single strand break repair Golgi membrane inter-male aggressive behavior territorial aggressive behavior damaged DNA binding ion channel activity calcium channel activity protein binding calmodulin binding nucleus nuclear envelope endoplasmic reticulum membrane plasma membrane integral component of plasma membrane ion transport calcium ion transport manganese ion transport positive regulation of cytosolic calcium ion concentration single fertilization acrosome reaction female courtship behavior regulation of gene expression endomembrane system store-operated calcium channel activity membrane integral component of membrane response to pheromone diacylglycerol binding dendrite membrane cation channel complex mating behavior, sex discrimination regulation of cytosolic calcium ion concentration transmembrane transport calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding negative regulation of male mating behavior uc012fqs.1 uc012fqs.2 uc012fqs.3 uc012fqs.4 
ENSMUST00000124198.4 Gm15408 ENSMUST00000124198.4 predicted gene 15408 (from RefSeq NR_040429.1) ENSMUST00000124198.1 ENSMUST00000124198.2 ENSMUST00000124198.3 NR_040429 uc009apa.1 uc009apa.2 uc009apa.3 uc009apa.4 uc009apa.5 uc009apa.1 uc009apa.2 uc009apa.3 uc009apa.4 uc009apa.5 
ENSMUST00000124214.3 Gm13793 ENSMUST00000124214.3 predicted gene 13793 (from RefSeq NR_168282.1) ENSMUST00000124214.1 ENSMUST00000124214.2 NR_168282 uc289yrx.1 uc289yrx.2 uc289yrx.3 uc289yrx.1 uc289yrx.2 uc289yrx.3 
ENSMUST00000124223.8 Katnip ENSMUST00000124223.8 katanin interacting protein, transcript variant 2 (from RefSeq NM_001358287.1) D430042O09Rik ENSMUST00000124223.1 ENSMUST00000124223.2 ENSMUST00000124223.3 ENSMUST00000124223.4 ENSMUST00000124223.5 ENSMUST00000124223.6 ENSMUST00000124223.7 F6XQI1 F6XQI1_MOUSE Katnip NM_001358287 uc012ftq.1 uc012ftq.2 uc012ftq.3 uc012ftq.1 uc012ftq.2 uc012ftq.3 
ENSMUST00000124226.3 Armcx4 ENSMUST00000124226.3 armadillo repeat containing, X-linked 4 (from RefSeq NM_001202500.3) Armcx4 E9PWM3 E9PWM3_MOUSE ENSMUST00000124226.1 ENSMUST00000124226.2 NM_001202500 uc033jsr.1 uc033jsr.2 uc033jsr.3 Membrane ; Single- pass membrane protein Mitochondrion outer membrane ; Single-pass membrane protein Belongs to the eutherian X-chromosome-specific Armcx family. molecular_function cellular_component biological_process uc033jsr.1 uc033jsr.2 uc033jsr.3 
ENSMUST00000124230.3 Gm8978 ENSMUST00000124230.3 predicted gene 8978 (from RefSeq NM_001323251.2) A0A494BBH0 A0A494BBH0_MOUSE ENSMUST00000124230.1 ENSMUST00000124230.2 Gm8978 NM_001323251 uc289rru.1 uc289rru.2 uc289rru.3 Belongs to the AB hydrolase superfamily. Lipase family. lipid metabolic process lipid catabolic process hydrolase activity hydrolase activity, acting on ester bonds uc289rru.1 uc289rru.2 uc289rru.3 
ENSMUST00000124310.5 Bfsp2 ENSMUST00000124310.5 beaded filament structural protein 2, phakinin, transcript variant 1 (from RefSeq NM_001002896.3) BFSP2_MOUSE ENSMUST00000124310.1 ENSMUST00000124310.2 ENSMUST00000124310.3 ENSMUST00000124310.4 NM_001002896 Q63832 Q6NVD9 Q6P5N4 Q8VDD6 uc009rgv.1 uc009rgv.2 uc009rgv.3 Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (PubMed:15037121, PubMed:27559293). Plays a role in maintenance of retinal lens optical clarity (PubMed:12454043). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA (By similarity). Found in a complex composed of PPL (via C-terminal linker domain), BFSP1 and BFSP2 in the retinal lens (PubMed:19029034). Within the complex interacts with PPL (via C-terminal linker domain) and with BFSP1 (PubMed:19029034). Identified in a complex that contains VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (PubMed:21745462). Interacts with LGSN (PubMed:18178558). Interacts with VIM (PubMed:19029034). Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm Cytoplasm, cytoskeleton Cytoplasm, cell cortex Note=Expressed primarily at the plasma membrane in peripheral lens fiber cells, however also localizes to the cytoplasm in mature lens fiber cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NVD9-1; Sequence=Displayed; Name=2; IsoId=Q6NVD9-2; Sequence=VSP_011111; Detected in retina lens fiber cells (at protein level) (PubMed:7679620, PubMed:12454043, PubMed:15037121, PubMed:14985306, PubMed:19029034, PubMed:21745462, PubMed:27559293). Also expressed in the lens epithelium, abundantly expressed in the anterior and anterolateral epithelium, less frequently expressed nearer the lens coronal equator (at protein level) (PubMed:27559293). Expressed in the retinal lens fiber cells from postnatal day 28 (P28) to P45 (PubMed:27559293). Expressed in retinal lens beaded filament structures from P37 onwards (PubMed:27559293). In strains 101, 129/SvJ and CBA, a polymorphism deletes the acceptor site of exon 2 which causes exon 1 to be spliced to exon 3 and generates a frameshift and premature stop codon (PubMed:12573667, PubMed:15037121). The polymorphism leads to retinal lens fiber cell nuclear opacity beginning at 1 month of age, opacity becomes more pronounced with age (PubMed:14985306). Reduced intermediate filaments and loss of the association of the lens fiber cell cytoskeleton with the plasma membrane (PubMed:15037121, PubMed:14985306). No overall change in lens fiber cell organization, regularity of hexagonal profiles, or positioning of cell nuclei (PubMed:12454043). Opacification of the retinal lens is evident at 1 month of age, with progressive loss of clarity to 10 months of age (PubMed:12454043). Reduced abundance and loss of distinction of intermediate filaments in retinal lens fiber cells (PubMed:15037121). Decreased protein abundance of BFSP1 in the retinal lens (PubMed:12454043). Complete loss of beaded filament structures in lens epithelial cells (PubMed:27559293). BFSP2 and VIM double knockout mice show a complete loss of the cytoplasmic cytoskeleton in retinal lens fiber cells (PubMed:15037121). Belongs to the intermediate filament family. structural molecule activity structural constituent of eye lens protein binding cytoplasm cytoskeleton intermediate filament plasma membrane cell cortex cytoskeleton organization visual perception membrane intermediate filament cytoskeleton organization cell maturation response to stimulus lens fiber cell development uc009rgv.1 uc009rgv.2 uc009rgv.3 
ENSMUST00000124320.2 Gm16222 ENSMUST00000124320.2 predicted gene 16222 (from RefSeq NR_152793.1) ENSMUST00000124320.1 NR_152793 uc287sig.1 uc287sig.2 uc287sig.1 uc287sig.2 
ENSMUST00000124322.2 Gm13380 ENSMUST00000124322.2 Gm13380 (from geneSymbol) ENSMUST00000124322.1 KY467837 uc289tmc.1 uc289tmc.2 uc289tmc.1 uc289tmc.2 
ENSMUST00000124326.2 Gm15561 ENSMUST00000124326.2 Gm15561 (from geneSymbol) ENSMUST00000124326.1 uc288gwk.1 uc288gwk.2 uc288gwk.1 uc288gwk.2 
ENSMUST00000124331.8 Msantd7 ENSMUST00000124331.8 Myb/SANT DNA binding domain containing 7, transcript variant 2 (from RefSeq NM_001388451.1) D6RJ26 ENSMUST00000124331.1 ENSMUST00000124331.2 ENSMUST00000124331.3 ENSMUST00000124331.4 ENSMUST00000124331.5 ENSMUST00000124331.6 ENSMUST00000124331.7 F6QKP8 Msantd7 NM_001388451 Q3UDN3 Q3UDN3_MOUSE uc008ieh.1 uc008ieh.2 uc008ieh.3 uc008ieh.1 uc008ieh.2 uc008ieh.3 
ENSMUST00000124334.8 Mus81 ENSMUST00000124334.8 MUS81 structure-specific endonuclease subunit, transcript variant 1 (from RefSeq NM_027877.4) ENSMUST00000124334.1 ENSMUST00000124334.2 ENSMUST00000124334.3 ENSMUST00000124334.4 ENSMUST00000124334.5 ENSMUST00000124334.6 ENSMUST00000124334.7 MUS81_MOUSE NM_027877 Q8R356 Q91ZJ0 uc008gdn.1 uc008gdn.2 uc008gdn.3 uc008gdn.4 Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; May self-associate. Interacts with CHEK2. Interacts with BLM, and this interaction may stimulate the endonuclease activity of MUS81. Interacts with EME2. Interacts with SLX4/BTBD12; this interaction is direct and links the MUS81-EME1 complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair. Interacts with DCLRE1B/Apollo (By similarity). Interacts with EME1. Interacts with RECQL5; this interaction stimulates mitotic DNA synthesis (By similarity). Nucleus, nucleolus. Note=Recruited to foci of DNA damage in S-phase cells. Expressed highly in testis. Expressed also in bone marrow, brain, thymus and to a lesser extent in heart and skeletal muscle, colon, kidney and spleen. Belongs to the XPF family. resolution of meiotic recombination intermediates double-strand break repair via break-induced replication DNA catabolic process, endonucleolytic DNA binding nuclease activity endonuclease activity nucleus nucleolus DNA repair DNA recombination cellular response to DNA damage stimulus hydrolase activity intra-S DNA damage checkpoint metal ion binding 3'-flap endonuclease activity Holliday junction resolvase complex response to intra-S DNA damage checkpoint signaling crossover junction endodeoxyribonuclease activity uc008gdn.1 uc008gdn.2 uc008gdn.3 uc008gdn.4 
ENSMUST00000124336.3 AV099323 ENSMUST00000124336.3 expressed sequence AV099323 (from RefSeq NR_190162.1) ENSMUST00000124336.1 ENSMUST00000124336.2 NR_190162 uc008mmm.1 uc008mmm.2 uc008mmm.3 uc008mmm.4 uc008mmm.1 uc008mmm.2 uc008mmm.3 uc008mmm.4 
ENSMUST00000124341.8 Slc4a3 ENSMUST00000124341.8 solute carrier family 4 (anion exchanger), member 3, transcript variant 1 (from RefSeq NM_009208.3) Ae3 B3A3_MOUSE ENSMUST00000124341.1 ENSMUST00000124341.2 ENSMUST00000124341.3 ENSMUST00000124341.4 ENSMUST00000124341.5 ENSMUST00000124341.6 ENSMUST00000124341.7 NM_009208 P16283 Q9ERP5 uc007bpv.1 uc007bpv.2 uc007bpv.3 uc007bpv.4 Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane. May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (By similarity). Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) + hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996; Evidence=; Inhibited by 4,4'-diisothiocyanatostilbene-2,2'- disulfonic acid (DIDS). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=FL-AE3; IsoId=P16283-1; Sequence=Displayed; Name=311-AE3; IsoId=P16283-2; Sequence=VSP_000464, VSP_000465; Name=14-AE3; IsoId=P16283-3; Sequence=VSP_000466, VSP_000467; Expressed in the brain. Belongs to the anion exchanger (TC 2.A.31) family. inorganic anion exchanger activity plasma membrane ion transport anion transport anion transmembrane transporter activity antiporter activity anion:anion antiporter activity inorganic anion transport bicarbonate transport membrane integral component of membrane enzyme binding regulation of intracellular pH transmembrane transport anion transmembrane transport uc007bpv.1 uc007bpv.2 uc007bpv.3 uc007bpv.4 
ENSMUST00000124374.2 Rapgef3os2 ENSMUST00000124374.2 Rapgef3os2 (from geneSymbol) AK009407 ENSMUST00000124374.1 uc289aye.1 uc289aye.2 uc289aye.1 uc289aye.2 
ENSMUST00000124376.2 Gm16310 ENSMUST00000124376.2 Gm16310 (from geneSymbol) ENSMUST00000124376.1 KY467764 uc289gec.1 uc289gec.2 uc289gec.1 uc289gec.2 
ENSMUST00000124392.2 Gm16058 ENSMUST00000124392.2 Gm16058 (from geneSymbol) ENSMUST00000124392.1 uc290tvq.1 uc290tvq.2 uc290tvq.1 uc290tvq.2 
ENSMUST00000124435.9 Gm11457 ENSMUST00000124435.9 Gm11457 (from geneSymbol) ENSMUST00000124435.1 ENSMUST00000124435.2 ENSMUST00000124435.3 ENSMUST00000124435.4 ENSMUST00000124435.5 ENSMUST00000124435.6 ENSMUST00000124435.7 ENSMUST00000124435.8 uc290ckz.1 uc290ckz.2 uc290ckz.3 uc290ckz.1 uc290ckz.2 uc290ckz.3 
ENSMUST00000124444.2 Cend1 ENSMUST00000124444.2 cell cycle exit and neuronal differentiation 1, transcript variant 2 (from RefSeq NM_021316.5) Bm88 CEND_MOUSE ENSMUST00000124444.1 NM_021316 Q9DBA0 Q9JKC6 uc009kky.1 uc009kky.2 uc009kky.3 Involved in neuronal differentiation. Homodimer (By similarity). Interacts with AHI1 (PubMed:23658157). Membrane ; Single-pass type IV membrane protein Expressed in the brain, including hypothalamus, brainstem, and hippocampus. Expression is high in 1-month-old mouse brain and then declines in mature mouse brains at the age of 3 and 7 months. Belongs to the CEND1 family. protein binding mitochondrion adult walking behavior membrane integral component of membrane cerebellum development cerebellar granular layer maturation cerebellar Purkinje cell differentiation radial glia guided migration of cerebellar granule cell negative regulation of cerebellar granule cell precursor proliferation cell differentiation neuron differentiation vesicle uc009kky.1 uc009kky.2 uc009kky.3 
ENSMUST00000124462.3 Arhgap27os3 ENSMUST00000124462.3 Rho GTPase activating protein 27, opposite strand 3 (from RefSeq NR_045346.1) ENSMUST00000124462.1 ENSMUST00000124462.2 NR_045346 uc029rok.1 uc029rok.2 uc029rok.3 uc029rok.1 uc029rok.2 uc029rok.3 
ENSMUST00000124469.2 Mccc1os ENSMUST00000124469.2 Mccc1os (from geneSymbol) AK036093 ENSMUST00000124469.1 uc290eph.1 uc290eph.2 uc290eph.1 uc290eph.2 
ENSMUST00000124470.8 Prlr ENSMUST00000124470.8 prolactin receptor, transcript variant 1 (from RefSeq NM_011169.5) ENSMUST00000124470.1 ENSMUST00000124470.2 ENSMUST00000124470.3 ENSMUST00000124470.4 ENSMUST00000124470.5 ENSMUST00000124470.6 ENSMUST00000124470.7 NM_011169 P15212 P15213 PRLR_MOUSE Q08501 Q62099 uc007vfy.1 uc007vfy.2 uc007vfy.3 uc007vfy.4 This is a receptor for the anterior pituitary hormone prolactin. Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent. Q08501; Q99490-2: AGAP2; Xeno; NbExp=2; IntAct=EBI-7737664, EBI-7737644; Membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=3; Name=PRL-R3; IsoId=Q08501-1; Sequence=Displayed; Name=PRL-R1; IsoId=Q08501-2; Sequence=VSP_001723, VSP_001724; Name=PRL-R2; IsoId=Q08501-3; Sequence=VSP_001721, VSP_001722; The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Belongs to the type I cytokine receptor family. Type 1 subfamily. cytokine receptor activity prolactin receptor activity protein binding activation of transmembrane receptor protein tyrosine kinase activity JAK-STAT cascade lactation response to bacterium external side of plasma membrane cell surface membrane integral component of membrane peptide hormone binding protein kinase binding cytokine binding regulation of cell adhesion regulation of epithelial cell differentiation prolactin signaling pathway receptor complex metal ion binding mammary gland epithelial cell differentiation prostate gland growth mammary gland alveolus development mammary gland epithelium development uc007vfy.1 uc007vfy.2 uc007vfy.3 uc007vfy.4 
ENSMUST00000124471.4 Gm12999 ENSMUST00000124471.4 Gm12999 (from geneSymbol) ENSMUST00000124471.1 ENSMUST00000124471.2 ENSMUST00000124471.3 uc290qlv.1 uc290qlv.2 uc290qlv.3 uc290qlv.4 uc290qlv.1 uc290qlv.2 uc290qlv.3 uc290qlv.4 
ENSMUST00000124482.3 Mrpl17 ENSMUST00000124482.3 mitochondrial ribosomal protein L17 (from RefSeq NM_025301.2) ENSMUST00000124482.1 ENSMUST00000124482.2 NM_025301 Q91VR0 Q9D8P4 RM17_MOUSE uc009izl.1 uc009izl.2 uc009izl.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D8P4-1; Sequence=Displayed; Name=2; IsoId=Q9D8P4-2; Sequence=VSP_018590, VSP_018591; Belongs to the bacterial ribosomal protein bL17 family. mitochondrial genome maintenance structural constituent of ribosome mitochondrion mitochondrial inner membrane mitochondrial large ribosomal subunit ribosome translation protein domain specific binding uc009izl.1 uc009izl.2 uc009izl.3 
ENSMUST00000124488.7 Trdmt1 ENSMUST00000124488.7 tRNA aspartic acid methyltransferase 1, transcript variant 8 (from RefSeq NR_184407.1) Dnmt2 ENSMUST00000124488.1 ENSMUST00000124488.2 ENSMUST00000124488.3 ENSMUST00000124488.4 ENSMUST00000124488.5 ENSMUST00000124488.6 NR_184407 Q5I0V6 Q5I0V6_MOUSE Trdmt1 uc008ika.1 uc008ika.2 uc008ika.3 uc008ika.4 Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. response to amphetamine cytoplasm methyltransferase activity tRNA methyltransferase activity transferase activity tRNA methylation methylation uc008ika.1 uc008ika.2 uc008ika.3 uc008ika.4 
ENSMUST00000124499.8 Lcp1 ENSMUST00000124499.8 lymphocyte cytosolic protein 1, transcript variant 1 (from RefSeq NM_001247984.2) ENSMUST00000124499.1 ENSMUST00000124499.2 ENSMUST00000124499.3 ENSMUST00000124499.4 ENSMUST00000124499.5 ENSMUST00000124499.6 ENSMUST00000124499.7 NM_001247984 PLSL_MOUSE Pls2 Q3UE24 Q61233 Q8R1X3 Q9CV77 uc007uqm.1 uc007uqm.2 uc007uqm.3 uc007uqm.4 Actin-binding protein. Plays a role in the activation of T- cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Monomer (By similarity). Interacts with AIF1 (PubMed:14756805). Interacts with actin (By similarity). Q61233; P47811: Mapk14; NbExp=5; IntAct=EBI-309345, EBI-298727; Cytoplasm, cytoskeleton Cell projection Cell junction Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28. Relocalizes to actin-rich cell projections upon serine phosphorylation (By similarity). Associated with the actin cytoskeleton at membrane ruffles. Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections (By similarity). stress fiber ruffle phagocytic cup podosome T cell activation involved in immune response actin binding integrin binding calcium ion binding protein binding cytoplasm cytosol cytoskeleton actin filament plasma membrane focal adhesion response to wounding protein kinase A signaling actin cytoskeleton membrane cell migration extracellular matrix disassembly cell junction filopodium animal organ regeneration actin filament bundle ruffle membrane regulation of intracellular protein transport identical protein binding cell projection metal ion binding perinuclear region of cytoplasm actin filament binding actin filament bundle assembly GTPase binding actin filament network formation positive regulation of podosome assembly uc007uqm.1 uc007uqm.2 uc007uqm.3 uc007uqm.4 
ENSMUST00000124503.2 Lncucc1 ENSMUST00000124503.2 Lncucc1 (from geneSymbol) AK136017 ENSMUST00000124503.1 uc007ile.1 uc007ile.2 uc007ile.1 uc007ile.2 
ENSMUST00000124513.3 Gm15247 ENSMUST00000124513.3 predicted gene 15247 (from RefSeq NR_189043.1) ENSMUST00000124513.1 ENSMUST00000124513.2 NR_189043 uc292ruz.1 uc292ruz.2 uc292ruz.3 uc292ruz.1 uc292ruz.2 uc292ruz.3 
ENSMUST00000124516.8 Myh1 ENSMUST00000124516.8 myosin, heavy polypeptide 1, skeletal muscle, adult (from RefSeq NM_030679.2) ENSMUST00000124516.1 ENSMUST00000124516.2 ENSMUST00000124516.3 ENSMUST00000124516.4 ENSMUST00000124516.5 ENSMUST00000124516.6 ENSMUST00000124516.7 MYH1_MOUSE NM_030679 Q32P18 Q5SX40 uc007jmg.1 uc007jmg.2 uc007jmg.3 Muscle contraction. Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1). nucleotide binding motor activity actin binding calmodulin binding ATP binding cytoplasm muscle myosin complex muscle contraction intercalated disc myosin complex myofibril A band myosin filament cytoplasmic ribonucleoprotein granule actin filament binding uc007jmg.1 uc007jmg.2 uc007jmg.3 
ENSMUST00000124538.3 Pabpc1l2b ENSMUST00000124538.3 poly(A) binding protein, cytoplasmic 1-like 2B (from RefSeq NM_001384267.1) ENSMUST00000124538.1 ENSMUST00000124538.2 NM_001384267 uc292pvq.1 uc292pvq.2 uc292pvq.3 uc292pvq.1 uc292pvq.2 uc292pvq.3 
ENSMUST00000124543.9 L3mbtl4 ENSMUST00000124543.9 L3MBTL4 histone methyl-lysine binding protein (from RefSeq NM_177278.5) A0A0A0MQK6 A0A0A0MQK6_MOUSE ENSMUST00000124543.1 ENSMUST00000124543.2 ENSMUST00000124543.3 ENSMUST00000124543.4 ENSMUST00000124543.5 ENSMUST00000124543.6 ENSMUST00000124543.7 ENSMUST00000124543.8 L3mbtl4 NM_177278 uc289mmq.1 uc289mmq.2 uc289mmq.3 Nucleus transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated zinc ion binding uc289mmq.1 uc289mmq.2 uc289mmq.3 
ENSMUST00000124549.9 Comtd1 ENSMUST00000124549.9 catechol-O-methyltransferase domain containing 1 (from RefSeq NM_026965.2) CMTD1_MOUSE ENSMUST00000124549.1 ENSMUST00000124549.2 ENSMUST00000124549.3 ENSMUST00000124549.4 ENSMUST00000124549.5 ENSMUST00000124549.6 ENSMUST00000124549.7 ENSMUST00000124549.8 NM_026965 Q8BIG7 uc007slt.1 uc007slt.2 uc007slt.3 Putative O-methyltransferase. Homodimer. Membrane ; Single-pass type II membrane protein Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. mitochondrion methyltransferase activity O-methyltransferase activity membrane integral component of membrane transferase activity methylation uc007slt.1 uc007slt.2 uc007slt.3 
ENSMUST00000124555.3 Gm13446 ENSMUST00000124555.3 predicted gene 13446 (from RefSeq NR_045894.1) ENSMUST00000124555.1 ENSMUST00000124555.2 NR_045894 uc008jko.1 uc008jko.2 uc008jko.3 uc008jko.4 uc008jko.1 uc008jko.2 uc008jko.3 uc008jko.4 
ENSMUST00000124565.4 Pierce2 ENSMUST00000124565.4 piercer of microtubule wall 2 (from RefSeq NM_001198789.1) Ccpg1os ENSMUST00000124565.1 ENSMUST00000124565.2 ENSMUST00000124565.3 NM_001198789 PIERCE2 PIRC2_MOUSE V9GXK1 uc009qqk.1 uc009qqk.2 uc009qqk.3 uc009qqk.4 uc009qqk.5 uc009qqk.6 uc009qqk.7 Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme. Cytoplasm, cytoskeleton, cilium axoneme Mutants born at the expected frequency (PubMed:34715025). At 8 dpc, they have a reduced beat frequency of nodal cilia (PubMed:34715025). The motility of tracheal cilia in adult mice is also affected (PubMed:34715025). 25% of tracheal cilia axonemes have missing dynein arms (PubMed:34715025). Double PIERCE1 and PIERCE2 mutants show high levels of embryonic and pre-weaning lethality. The few mice that survive birth display hydrocephalus and laterality abnormalities, dying by 20 days of age (PubMed:34715025). Belongs to the PIERCE2 family. uc009qqk.1 uc009qqk.2 uc009qqk.3 uc009qqk.4 uc009qqk.5 uc009qqk.6 uc009qqk.7 
ENSMUST00000124572.2 AV064505 ENSMUST00000124572.2 expressed sequence AV064505 (from RefSeq NR_126562.1) ENSMUST00000124572.1 NR_126562 uc057anu.1 uc057anu.2 uc057anu.1 uc057anu.2 
ENSMUST00000124575.2 4930528G23Rik ENSMUST00000124575.2 RIKEN cDNA 4930528G23 gene (from RefSeq NR_131024.1) ENSMUST00000124575.1 NR_131024 uc057afh.1 uc057afh.2 uc057afh.1 uc057afh.2 
ENSMUST00000124586.2 Mmp24os1 ENSMUST00000124586.2 matrix metallopeptidase 24 opposite strand transcript 1 (from RefSeq NM_001384169.1) A0A0N4SW31 A0A0N4SW31_MOUSE BC029722 ENSMUST00000124586.1 Mmp24os1 NM_001384169 uc008nlk.1 uc008nlk.2 uc008nlk.3 uc008nlk.4 uc008nlk.5 uc008nlk.1 uc008nlk.2 uc008nlk.3 uc008nlk.4 uc008nlk.5 
ENSMUST00000124606.3 Smim43 ENSMUST00000124606.3 small integral membrane protein 43 (from RefSeq NM_001384269.1) A0A286YD83 ENSMUST00000124606.1 ENSMUST00000124606.2 Gm11549 NM_001384269 SIM43_MOUSE Smim43 uc008ozk.1 uc008ozk.2 uc008ozk.3 uc008ozk.4 Required for mesendoderm differentiation (PubMed:35810171). Interacts with glucose transporters and promotes glucose uptake (PubMed:35810171). Probably augments the glucose uptake capacity of glucose transporter proteins to meet the energy needs of mesendoderm differentiation (PubMed:35810171). Interacts with glucose transporters SLC2A1/GLUT1 and SLC2A3/GLUT3; the interactions may promote SLC2A1- and SLC2A3-mediated glucose transport to meet the energy needs of mesendoderm differentiation. A0A286YD83; P17809: Slc2a1; NbExp=5; IntAct=EBI-46438951, EBI-646060; A0A286YD83; P32037: Slc2a3; NbExp=6; IntAct=EBI-46438951, EBI-21145965; Cell membrane ; Single-pass membrane protein Accumulates in the posterior primitive streak of mid-gastrulation embryos at 7.0 dpc (PubMed:35810171). In the adult, highly abundant and enriched in the brain compared to other organs (PubMed:35810171). membrane integral component of membrane uc008ozk.1 uc008ozk.2 uc008ozk.3 uc008ozk.4 
ENSMUST00000124643.3 4931431C16Rik ENSMUST00000124643.3 RIKEN cDNA 4931431C16 gene (from RefSeq NR_045807.1) ENSMUST00000124643.1 ENSMUST00000124643.2 NR_045807 uc008xdw.1 uc008xdw.2 uc008xdw.3 uc008xdw.1 uc008xdw.2 uc008xdw.3 
ENSMUST00000124677.2 Speer3 ENSMUST00000124677.2 spermatogenesis associated glutamate (E)-rich protein 3 (from RefSeq NM_027650.3) ENSMUST00000124677.1 NM_027650 Speer3 W4VSP1 W4VSP1_MOUSE uc012dsg.1 uc012dsg.2 uc012dsg.3 molecular_function cellular_component biological_process uc012dsg.1 uc012dsg.2 uc012dsg.3 
ENSMUST00000124728.2 Gm14397 ENSMUST00000124728.2 Gm14397 (from geneSymbol) ENSMUST00000124728.1 uc290cng.1 uc290cng.2 uc290cng.1 uc290cng.2 
ENSMUST00000124729.4 Cyp2j8 ENSMUST00000124729.4 cytochrome P450, family 2, subfamily j, polypeptide 8, transcript variant 2 (from RefSeq NM_001370972.1) Cyp2j7-ps Cyp2j8 ENSMUST00000124729.1 ENSMUST00000124729.2 ENSMUST00000124729.3 G3UZ38 G3UZ38_MOUSE NM_001370972 uc009vcs.1 uc009vcs.2 uc009vcs.3 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc009vcs.1 uc009vcs.2 uc009vcs.3 
ENSMUST00000124745.8 Dda1 ENSMUST00000124745.8 DET1 and DDB1 associated 1, transcript variant 1 (from RefSeq NM_025600.2) DDA1_MOUSE Dda1 ENSMUST00000124745.1 ENSMUST00000124745.2 ENSMUST00000124745.3 ENSMUST00000124745.4 ENSMUST00000124745.5 ENSMUST00000124745.6 ENSMUST00000124745.7 NM_025600 Q3UDQ1 Q9D9Z5 uc009mdi.1 uc009mdi.2 uc009mdi.3 uc009mdi.4 uc009mdi.5 Functions as a component of numerous distinct DCX (DDB1-CUL4- X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex. Protein modification; protein ubiquitination. Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin- protein ligase complexes which consist of a core of DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1. Component of the DCX(DCAF15) complex, also named CLR4(DCAF15) complex, composed of DCAF15, DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1. Part of the DDD core complex containing DET1, DDA1 and DDB1; the DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes. Belongs to the DDA1 family. molecular_function regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process Cul4-RING E3 ubiquitin ligase complex uc009mdi.1 uc009mdi.2 uc009mdi.3 uc009mdi.4 uc009mdi.5 
ENSMUST00000124746.2 Gm15906 ENSMUST00000124746.2 Gm15906 (from geneSymbol) ENSMUST00000124746.1 uc290qat.1 uc290qat.2 uc290qat.1 uc290qat.2 
ENSMUST00000124773.3 Vmn2r66 ENSMUST00000124773.3 vomeronasal 2, receptor 66 (from RefSeq NM_001033878.3) ENSMUST00000124773.1 ENSMUST00000124773.2 K7N6R9 K7N6R9_MOUSE NM_001033878 Vmn2r66 uc012foh.1 uc012foh.2 uc012foh.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012foh.1 uc012foh.2 uc012foh.3 
ENSMUST00000124786.2 Gm12798 ENSMUST00000124786.2 Gm12798 (from geneSymbol) ENSMUST00000124786.1 uc290obz.1 uc290obz.2 uc290obz.1 uc290obz.2 
ENSMUST00000124792.2 Gm11906 ENSMUST00000124792.2 Gm11906 (from geneSymbol) ENSMUST00000124792.1 uc290lmp.1 uc290lmp.2 uc290lmp.1 uc290lmp.2 
ENSMUST00000124814.2 Gm2200 ENSMUST00000124814.2 Gm2200 (from geneSymbol) AK139882 ENSMUST00000124814.1 uc292npd.1 uc292npd.2 uc292npd.1 uc292npd.2 
ENSMUST00000124829.2 8430437L04Rik ENSMUST00000124829.2 RIKEN cDNA 8430437L04 gene (from RefSeq NR_040503.1) ENSMUST00000124829.1 NR_040503 uc029tya.1 uc029tya.2 uc029tya.1 uc029tya.2 
ENSMUST00000124830.3 Dsp ENSMUST00000124830.3 desmoplakin, transcript variant 1 (from RefSeq NM_023842.3) DESP_MOUSE E9Q557 ENSMUST00000124830.1 ENSMUST00000124830.2 NM_023842 uc007qdk.1 uc007qdk.2 uc007qdk.3 Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). Homodimer (By similarity). Interacts with COL17A1 (via cytoplasmic region) (By similarity). Interacts with DSC2 (By similarity). Interacts with PKP1 (By similarity). Interacts with PKP2 (By similarity). Interacts weakly with TMEM65 (PubMed:26403541). Cell junction, desmosome Cell membrane Note=Localizes at the intercalated disk in cardiomyocytes. The N-terminal region is required for localization to the desmosomal plaque and interacts with the N-terminal region of PKP1. Belongs to the plakin or cytolinker family. cornified envelope desmosome organization ventricular compact myocardium morphogenesis protein kinase C binding protein binding cytoplasm cytoskeleton plasma membrane cell-cell junction fascia adherens intercalated disc membrane basolateral plasma membrane peptide cross-linking cell junction desmosome keratinocyte differentiation adherens junction organization wound healing skin development intermediate filament cytoskeleton organization intermediate filament organization cell adhesion molecule binding protein localization to adherens junction bundle of His cell-Purkinje myocyte adhesion involved in cell communication regulation of heart rate by cardiac conduction scaffold protein binding cell-cell adhesion regulation of ventricular cardiac muscle cell action potential intermediate filament uc007qdk.1 uc007qdk.2 uc007qdk.3 
ENSMUST00000124840.2 Spaca9 ENSMUST00000124840.2 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) of multiciliated respiratory cells and the distal singlet microtubules of monoflagellated spermatozoa. May stabilize the protofilaments to which they are bound. (from UniProt Q7TPM5) AK155297 ENSMUST00000124840.1 Q3TTJ0 Q3U293 Q7TPM5 Q9D9W4 SACA9_MOUSE Spaca9 uc289ulf.1 uc289ulf.2 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) of multiciliated respiratory cells and the distal singlet microtubules of monoflagellated spermatozoa. May stabilize the protofilaments to which they are bound. Interacts with CABP1 and CALR (PubMed:24256100). Interacts with INCA1 (By similarity). Interacts with microtubules (By similarity). Cytoplasm Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasm, cytoskeleton, cilium basal body Cell projection, cilium, flagellum Nucleus Cytoplasm, cytoskeleton, cilium axoneme Note=In caudal sperms localizes onto sperm head. Is also present on midpiece and principle piece of sperm tails. Acrosome and sperm tail localization is regulated by Y-chromosome. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TPM5-1; Sequence=Displayed; Name=2; IsoId=Q7TPM5-2; Sequence=VSP_046487, VSP_046488; Expressed in sperm (at protein level) (Ref.4). Expressed from almost all the cell types of testis, with abundant expression in round and elongated spermatids (at protein level) (PubMed:24256100). Predominantly expressed in tissues containing motile cilia (PubMed:27914912). Expressed in the developing fetal lung epithelium (at protein level). Expression is activated by FOXJ1 and NOTO. Deficient mice are viable, fertile, and have no clear phenotypic differences from wild-type mice. acrosomal vesicle nucleus cytoplasm cytoskeleton cytoplasmic microtubule cilium biological_process cytoplasmic vesicle motile cilium ciliary basal body sperm flagellum cell projection calcium-dependent protein binding ciliary base uc289ulf.1 uc289ulf.2 
ENSMUST00000124853.2 Gm15856 ENSMUST00000124853.2 Gm15856 (from geneSymbol) AK042117 ENSMUST00000124853.1 uc291imm.1 uc291imm.2 uc291imm.1 uc291imm.2 
ENSMUST00000124855.2 Gm11674 ENSMUST00000124855.2 Gm11674 (from geneSymbol) AK041006 ENSMUST00000124855.1 uc288dgf.1 uc288dgf.2 uc288dgf.1 uc288dgf.2 
ENSMUST00000124863.4 Gm15517 ENSMUST00000124863.4 predicted gene 15517 (from RefSeq NM_001384596.1) A0A1B0GRQ9 A0A1B0GRQ9_MOUSE ENSMUST00000124863.1 ENSMUST00000124863.2 ENSMUST00000124863.3 Gm15517 NM_001384596 uc009goz.1 uc009goz.2 uc009goz.3 membrane integral component of membrane uc009goz.1 uc009goz.2 uc009goz.3 
ENSMUST00000124865.2 Gm11537 ENSMUST00000124865.2 Gm11537 (from geneSymbol) ENSMUST00000124865.1 uc288brp.1 uc288brp.2 uc288brp.1 uc288brp.2 
ENSMUST00000124877.3 Smim36 ENSMUST00000124877.3 Membrane ; Single-pass membrane protein (from UniProt A0A1B0GRQ0) A0A1B0GRQ0 BC106170 ENSMUST00000124877.1 ENSMUST00000124877.2 Gm45716 SIM36_MOUSE SMIM36 uc288bik.1 uc288bik.2 Membrane ; Single-pass membrane protein membrane integral component of membrane uc288bik.1 uc288bik.2 
ENSMUST00000124888.8 Lgals8 ENSMUST00000124888.8 Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. (from UniProt Q9JL15) AK083350 ENSMUST00000124888.1 ENSMUST00000124888.2 ENSMUST00000124888.3 ENSMUST00000124888.4 ENSMUST00000124888.5 ENSMUST00000124888.6 ENSMUST00000124888.7 LEG8_MOUSE Q9JL15 uc007plo.1 uc007plo.2 uc007plo.3 uc007plo.4 uc007plo.5 Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. Homodimer. Interacts with CALCOCO2/NDP52. Interacts with PDPN; the interaction is glycosylation-dependent; may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix. Cytoplasmic vesicle Cytoplasm, cytosol Contains two homologous but distinct carbohydrate-binding domains. Name=Functional Glycomics Gateway - Glycan Binding; Note=Galectin-8; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Stlect_203"; plasma cell differentiation integrin binding cytoplasm cytosol autophagy carbohydrate binding T cell costimulation cytoplasmic vesicle cellular response to virus xenophagy lymphatic endothelial cell migration uc007plo.1 uc007plo.2 uc007plo.3 uc007plo.4 uc007plo.5 
ENSMUST00000124899.8 Asb7 ENSMUST00000124899.8 ankyrin repeat and SOCS box-containing 7, transcript variant 2 (from RefSeq NR_003961.1) ASB7_MOUSE ENSMUST00000124899.1 ENSMUST00000124899.2 ENSMUST00000124899.3 ENSMUST00000124899.4 ENSMUST00000124899.5 ENSMUST00000124899.6 ENSMUST00000124899.7 G3UVX4 NR_003961 Q91ZU0 uc009hhn.1 uc009hhn.2 uc009hhn.3 uc009hhn.4 uc009hhn.5 uc009hhn.6 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Interacts with CUL5 and RNF7. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. Belongs to the ankyrin SOCS box (ASB) family. molecular_function cellular_component biological_process protein ubiquitination intracellular signal transduction uc009hhn.1 uc009hhn.2 uc009hhn.3 uc009hhn.4 uc009hhn.5 uc009hhn.6 
ENSMUST00000124912.3 Gm11280 ENSMUST00000124912.3 Gm11280 (from geneSymbol) AK015655 ENSMUST00000124912.1 ENSMUST00000124912.2 uc288lgb.1 uc288lgb.2 uc288lgb.3 uc288lgb.1 uc288lgb.2 uc288lgb.3 
ENSMUST00000124927.3 Or1e29 ENSMUST00000124927.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRX7) B7ZC58 ENSMUST00000124927.1 ENSMUST00000124927.2 Olfr389 Or1e29 Q7TRX7 Q7TRX7_MOUSE uc288aab.1 uc288aab.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288aab.1 uc288aab.2 
ENSMUST00000124953.2 Gm15563 ENSMUST00000124953.2 Gm15563 (from geneSymbol) ENSMUST00000124953.1 uc292iif.1 uc292iif.2 uc292iif.1 uc292iif.2 
ENSMUST00000124968.8 Pcbd2 ENSMUST00000124968.8 Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920, ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96; Evidence=; (from UniProt A0A0R4J1R7) A0A0R4J1R7 A0A0R4J1R7_MOUSE AK012465 ENSMUST00000124968.1 ENSMUST00000124968.2 ENSMUST00000124968.3 ENSMUST00000124968.4 ENSMUST00000124968.5 ENSMUST00000124968.6 ENSMUST00000124968.7 Pcbd2 uc288ndk.1 uc288ndk.2 Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920, ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96; Evidence=; Belongs to the pterin-4-alpha-carbinolamine dehydratase family. tetrahydrobiopterin biosynthetic process 4-alpha-hydroxytetrahydrobiopterin dehydratase activity uc288ndk.1 uc288ndk.2 
ENSMUST00000124973.9 Tpr ENSMUST00000124973.9 translocated promoter region, nuclear basket protein (from RefSeq NM_133780.3) ENSMUST00000124973.1 ENSMUST00000124973.2 ENSMUST00000124973.3 ENSMUST00000124973.4 ENSMUST00000124973.5 ENSMUST00000124973.6 ENSMUST00000124973.7 ENSMUST00000124973.8 F6ZDS4 NM_133780 Q8R4A0 Q921B9 TPR_MOUSE uc007cyb.1 uc007cyb.2 uc007cyb.3 uc007cyb.4 Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress- induced conditions. Plays a limited role in the regulation of nuclear protein export. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC- associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases (By similarity). Homodimer. Part of the nuclear pore complex (NPC). Associates with the XPO1/CRM1-mediated nuclear export complex, the Importin alpha/Importin beta receptor and the dynein 1 complex. Interacts (via C-terminal domain) with the KPNB1; the interaction occurs in a RanGTP- dependent manner. Interacts (via C-terminal region and phosphorylated form) with MAPK1/ERK2 (via phosphorylated form); the interaction requires dimerization of MAPK1/ERK2 and increases following EGF stimulation. Interacts with MAPK3/ERK1; the interaction increases following EGF stimulation. Interacts (via coiled coil region) with NUP153; the interaction is direct. Interacts with HSF1; the interaction increases in a stress-responsive manner and stimulates export of stress-induced HSP70 mRNA. Interacts with huntingtin/HTT; the interaction is inhibited by aggregated huntingtin/HTT forms with expanded polyglutamine stretch. Interacts with MAD1L1 (via N-terminal region), MAD2L1, and TTK; the interactions occurs in a microtubule- independent manner. Interacts (via middle region) with DYNLL1. Interacts with DCTN1, dynein, NUP153 and tubulin. Interacts with MTA1 (By similarity). Interacts with IFI204 (via C-terminal region). Interacts with IFI203. Nucleus Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side Nucleus envelope Nucleus, nuclear pore complex toplasm Cytoplasm, cytoskeleton, spindle Chromosome, centromere, kinetochore Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Detected as discrete intranuclear foci with IFI204 (By similarity). In interphase, localizes to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Detected exclusively to the cytoplasmic margin of NPC (By similarity). Docking to the inner nucleoplasmic side of the NPC is mediated through binding to nucleoporins. Anchored by NUP153 to the NPC. The assembly of the NPC is a stepwise process in which Trp-containing peripheral structures assemble after other components, including p62. Detected as filaments that emanate from the nuclear basket of the NPC and extend to the nucleolus to delineate a chromatin-free network extending from the nuclear envelope to the perinucleolar region. Detected in diffuse and discrete spheroidal intranuclear foci. Nucleocytoplasmic shuttling protein imported into the nucleus in a XPO1/CRM1- and Importin alpha/Importin beta receptor-dependent manner. Remains localized to the nuclear membrane after poliovirus (PV) infection. During mitosis, remains associated with the nuclear envelope until prometaphase. Associated with the mitotic spindle from late prometaphase until anaphase. Reorganized during mitosis in a viscous and dynamic nuclear- derived spindle matrix that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner. Recruited to the reforming nuclear envelope during telophase and cytokinesis. Detected at kinetochores during prometaphase. Colocalizes with MAD2L1 in the spindle matrix but not at kinetochore. Colocalizes with dynein, dynactin, tubulin at kinetochore during the metaphase-anaphase transition. Colocalizes with DYNLL1 at the mitotic spindle (By similarity). Expressed in the heart, liver, kidney, spleen, lung and skeletal muscles. Expressed both maternally and zygotically. Expressed at the mid two-cell stage and in the embryo at 7, 11, 15 and 17 dpc. The N-terminal domain mediates intranuclear attachment to the nuclear pore complex. The C-terminal domain mediates its nuclear import (By similarity). Phosphorylated. Phosphorylation occurs on serine and threonine residues (comprised in the C-terminal region) by MAPK1/ERK2 and stabilizes the interaction between these two proteins (By similarity). Belongs to the TPR family. negative regulation of transcription from RNA polymerase II promoter chromosome, centromeric region kinetochore chromatin binding mRNA binding protein binding nucleus nuclear envelope nuclear pore chromosome cytoplasm spindle cytoskeleton cytoplasmic dynein complex RNA import into nucleus RNA export from nucleus protein import into nucleus protein export from nucleus nuclear pore organization cell cycle mitotic spindle assembly checkpoint regulation of mitotic sister chromatid separation protein transport tubulin binding membrane structural constituent of nuclear pore extrinsic component of membrane heat shock protein binding positive regulation of heterochromatin assembly nuclear membrane mRNA export from nucleus in response to heat stress regulation of protein localization nuclear periphery cellular response to heat cellular response to interferon-alpha positive regulation of protein import into nucleus nuclear inclusion body protein homodimerization activity nuclear pore nuclear basket negative regulation of translational initiation positive regulation of protein export from nucleus negative regulation of RNA export from nucleus mitogen-activated protein kinase binding mRNA transport cell division dynein complex binding response to epidermal growth factor mitotic spindle positive regulation of mitotic cell cycle spindle assembly checkpoint positive regulation of intracellular protein transport regulation of mitotic spindle assembly regulation of protein stability regulation of protein import into nucleus protein anchor nuclear matrix organization nuclear pore complex assembly uc007cyb.1 uc007cyb.2 uc007cyb.3 uc007cyb.4 
ENSMUST00000124976.2 Gm16234 ENSMUST00000124976.2 Gm16234 (from geneSymbol) ENSMUST00000124976.1 uc287pro.1 uc287pro.2 uc287pro.1 uc287pro.2 
ENSMUST00000124989.2 Gm12410 ENSMUST00000124989.2 Gm12410 (from geneSymbol) ENSMUST00000124989.1 uc290mmt.1 uc290mmt.2 uc290mmt.1 uc290mmt.2 
ENSMUST00000124992.8 Ube2j1 ENSMUST00000124992.8 ubiquitin-conjugating enzyme E2J 1, transcript variant 1 (from RefSeq NM_019586.4) ENSMUST00000124992.1 ENSMUST00000124992.2 ENSMUST00000124992.3 ENSMUST00000124992.4 ENSMUST00000124992.5 ENSMUST00000124992.6 ENSMUST00000124992.7 NM_019586 Ncube1 Q9DC92 Q9JJZ4 UB2J1_MOUSE uc008sfp.1 uc008sfp.2 uc008sfp.3 Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress. Plays a role in MAPKAPK2-dependent translational control of TNF-alpha synthesis. Acts also as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin- protein ligase RNF26. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence=; Protein modification; protein ubiquitination. Component of the HRD1 complex, which comprises at least SYNV1/HRD1, DERL1/2, FAM8A1, HERPUD1/HERP, OS9, SEL1L and UBE2J1. Interacts with E3 ligase RNF26. Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Phosphorylated at Ser-184 in a cytosolic stress-dependent manner by MAP kinase p38 MAPKAPK2. Phosphorylated UBE2J1 is rapidly ubiquitinated and subsequently degraded by the proteasome. Deletion mice have reduced viability and fail to thrive early after birth. Specific components of the ER dislocation machinery are up-regulated. In addition, males are sterile due to a defect in late spermatogenesis. Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding ATP binding endoplasmic reticulum endoplasmic reticulum membrane spermatid development membrane integral component of membrane protein ubiquitination transferase activity protein N-linked glycosylation via asparagine ER-associated ubiquitin-dependent protein catabolic process ubiquitin protein ligase binding regulation of tumor necrosis factor biosynthetic process ubiquitin conjugating enzyme activity negative regulation of retrograde protein transport, ER to cytosol uc008sfp.1 uc008sfp.2 uc008sfp.3 
ENSMUST00000125009.9 Grm5 ENSMUST00000125009.9 glutamate receptor, metabotropic 5, transcript variant a (from RefSeq NM_001081414.2) E9QMC2 E9QMC2_MOUSE ENSMUST00000125009.1 ENSMUST00000125009.2 ENSMUST00000125009.3 ENSMUST00000125009.4 ENSMUST00000125009.5 ENSMUST00000125009.6 ENSMUST00000125009.7 ENSMUST00000125009.8 F6WSV0 Grm5 NM_001081414 uc009ifr.1 uc009ifr.2 uc009ifr.3 uc009ifr.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 3 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009ifr.1 uc009ifr.2 uc009ifr.3 uc009ifr.4 
ENSMUST00000125068.2 Gm12120 ENSMUST00000125068.2 Gm12120 (from geneSymbol) ENSMUST00000125068.1 uc287xjd.1 uc287xjd.2 uc287xjd.1 uc287xjd.2 
ENSMUST00000125071.2 Gm16185 ENSMUST00000125071.2 Gm16185 (from geneSymbol) ENSMUST00000125071.1 uc292jwc.1 uc292jwc.2 uc292jwc.1 uc292jwc.2 
ENSMUST00000125091.2 Gata3un ENSMUST00000125091.2 Gata3 upstream neighbor (from RefSeq NR_040511.1) ENSMUST00000125091.1 NR_040511 uc008ihi.1 uc008ihi.2 uc008ihi.1 uc008ihi.2 
ENSMUST00000125095.2 Gm13480 ENSMUST00000125095.2 Gm13480 (from geneSymbol) AK044108 ENSMUST00000125095.1 uc289was.1 uc289was.2 uc289was.1 uc289was.2 
ENSMUST00000125121.2 Gm14260 ENSMUST00000125121.2 Gm14260 (from geneSymbol) ENSMUST00000125121.1 uc290cvo.1 uc290cvo.2 uc290cvo.1 uc290cvo.2 
ENSMUST00000125161.3 Gm40614 ENSMUST00000125161.3 Gm40614 (from geneSymbol) ENSMUST00000125161.1 ENSMUST00000125161.2 uc287qbi.1 uc287qbi.2 uc287qbi.1 uc287qbi.2 
ENSMUST00000125172.8 Phb1 ENSMUST00000125172.8 prohibitin 1 (from RefSeq NM_008831.4) ENSMUST00000125172.1 ENSMUST00000125172.2 ENSMUST00000125172.3 ENSMUST00000125172.4 ENSMUST00000125172.5 ENSMUST00000125172.6 ENSMUST00000125172.7 NM_008831 P24142 P67778 PHB1_MOUSE Phb Q3UB75 Q5SQG4 uc007lan.1 uc007lan.2 uc007lan.3 Protein with pleiotropic attributes mediated in a cell- compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:23241883, PubMed:24856930, PubMed:29324904). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (PubMed:24947361). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (PubMed:24856930). Regulates mitochondrial respiration activity playing a role in cellular aging (PubMed:11302691). The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:31819158). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (By similarity). In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses (By similarity). Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells (By similarity). In the plasma membrane, cooperates with CD86 to mediate CD86- signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (PubMed:23241883). Upon CD40 engagement, required to activate NF-kappa- B signaling pathway via phospholipase C and protein kinase C activation (PubMed:23241883). (Microbial infection) In neuronal cells, cell surface- expressed PHB1 is involved in human enterovirus 71/EV-71 entry into neuronal cells specifically, while membrane-bound mitochondrial PHB1 associates with the virus replication complex and facilitates viral replication (PubMed:29324904). May serve as a receptor for EV71 (PubMed:29324904). Target of the anti-cancer drug Rocaglamide (Roc- A). Interacts with PHB2. Interacts with STOML2. Interacts with CD86 (via cytoplasmic domain); the interactions increases after priming with CD40 (PubMed:23241883). (Microbial infection) Interacts with human enterovirus 71/EV- 71 capsid protein VP0, protein 3CD and protease 3C. P67778; O35129: Phb2; NbExp=3; IntAct=EBI-298507, EBI-445002; Mitochondrion inner membrane cleus Cell membrane Cytoplasm Widely expressed in different tissues. Throughout gestation, highly expressed in brown fat, heart, liver, developing renal tubules and neurons, and detected at lower levels in tissues such as lung and exocrine pancreas. In B cells, expression is increased by CD40 engagement (at protein level). Belongs to the prohibitin family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding ovarian follicle development ovarian follicle atresia complement component C3a binding complement component C3b binding protein binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial inner membrane early endosome plasma membrane integral component of plasma membrane regulation of transcription, DNA-templated mitochondrion organization protein C-terminus binding negative regulation of cell proliferation cell surface positive regulation of gene expression positive regulation of cell death negative regulation of transcription by competitive promoter binding postsynaptic density membrane histone deacetylation enzyme binding mitochondrial crista negative regulation of cell growth animal organ regeneration extrinsic component of mitochondrial outer membrane proteinase activated receptor binding response to cytokine response to immobilization stress negative regulation of protein catabolic process response to drug histone deacetylase binding negative regulation of apoptotic process myelin sheath response to peptide hormone transcription regulatory region DNA binding response to ethanol positive regulation of G-protein coupled receptor protein signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of complement activation protein stabilization progesterone receptor signaling pathway negative regulation of androgen receptor signaling pathway negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to interleukin-6 DNA biosynthetic process extrinsic component of presynaptic active zone membrane glutamatergic synapse GABA-ergic synapse negative regulation of glucocorticoid receptor signaling pathway uc007lan.1 uc007lan.2 uc007lan.3 
ENSMUST00000125173.3 1810059C17Rik ENSMUST00000125173.3 1810059C17Rik (from geneSymbol) AK007903 ENSMUST00000125173.1 ENSMUST00000125173.2 uc289tid.1 uc289tid.2 uc289tid.3 uc289tid.1 uc289tid.2 uc289tid.3 
ENSMUST00000125185.2 Gm13860 ENSMUST00000125185.2 Gm13860 (from geneSymbol) ENSMUST00000125185.1 uc291dld.1 uc291dld.2 uc291dld.1 uc291dld.2 
ENSMUST00000125204.2 Selenok-ps1 ENSMUST00000125204.2 selenoprotein K, pseudogene 1 (from RefSeq NR_004857.1) ENSMUST00000125204.1 NR_004857 uc011xse.1 uc011xse.2 uc011xse.3 uc011xse.1 uc011xse.2 uc011xse.3 
ENSMUST00000125209.9 Mctp1 ENSMUST00000125209.9 multiple C2 domains, transmembrane 1, transcript variant 1 (from RefSeq NM_030174.3) E9PV86 ENSMUST00000125209.1 ENSMUST00000125209.2 ENSMUST00000125209.3 ENSMUST00000125209.4 ENSMUST00000125209.5 ENSMUST00000125209.6 ENSMUST00000125209.7 ENSMUST00000125209.8 MCTP1_MOUSE Mctp1 NM_030174 uc007rgn.1 uc007rgn.2 uc007rgn.3 uc007rgn.4 Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds Ca(2+) via the C2 domains in absence of phospholipids. ; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Recycling endosome Endoplasmic reticulum membrane Belongs to the MCTP family. calcium ion binding endosome endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane cell junction negative regulation of cell migration synaptic vesicle membrane cytoplasmic vesicle synapse negative regulation of endocytosis regulation of neurotransmitter secretion recycling endosome negative regulation of response to oxidative stress uc007rgn.1 uc007rgn.2 uc007rgn.3 uc007rgn.4 
ENSMUST00000125237.2 Gm12811 ENSMUST00000125237.2 Gm12811 (from geneSymbol) ENSMUST00000125237.1 uc290oqv.1 uc290oqv.2 uc290oqv.1 uc290oqv.2 
ENSMUST00000125240.2 Gm11216 ENSMUST00000125240.2 Gm11216 (from geneSymbol) ENSMUST00000125240.1 uc290nfc.1 uc290nfc.2 uc290nfc.1 uc290nfc.2 
ENSMUST00000125244.9 A230103J11Rik ENSMUST00000125244.9 RIKEN cDNA A230103J11 gene, transcript variant 2 (from RefSeq NR_110582.1) ENSMUST00000125244.1 ENSMUST00000125244.2 ENSMUST00000125244.3 ENSMUST00000125244.4 ENSMUST00000125244.5 ENSMUST00000125244.6 ENSMUST00000125244.7 ENSMUST00000125244.8 NR_110582 uc009mpb.1 uc009mpb.2 uc009mpb.3 uc009mpb.4 uc009mpb.1 uc009mpb.2 uc009mpb.3 uc009mpb.4 
ENSMUST00000125249.3 Isoc2a ENSMUST00000125249.3 isochorismatase domain containing 2a (from RefSeq NM_001101598.1) ENSMUST00000125249.1 ENSMUST00000125249.2 ISC2A_MOUSE Isoc2 Isoc2a NM_001101598 P85094 uc012ewz.1 uc012ewz.2 uc012ewz.3 uc012ewz.4 Interacts with CDKN2A. Cytoplasm Nucleus Note=Localizes to the nucleus in the presence of CDKN2A. Ubiquitous. Expressed predominantly in uterus, stomach and urinary tract. Belongs to the isochorismatase family. molecular_function catalytic activity nucleus cytoplasm mitochondrion protein destabilization uc012ewz.1 uc012ewz.2 uc012ewz.3 uc012ewz.4 
ENSMUST00000125275.2 Gm11947 ENSMUST00000125275.2 Gm11947 (from geneSymbol) ENSMUST00000125275.1 uc287wep.1 uc287wep.2 uc287wep.1 uc287wep.2 
ENSMUST00000125276.2 Slc35c1 ENSMUST00000125276.2 solute carrier family 35, member C1, transcript variant 2 (from RefSeq NM_145832.3) ENSMUST00000125276.1 F6QFJ0 NM_145832 Q8R2I1 Q8R2I1_MOUSE Slc35c1 fuct1 uc008kyc.1 uc008kyc.2 uc008kyc.3 uc008kyc.4 Membrane ; Multi- pass membrane protein Belongs to the TPT transporter family. SLC35C subfamily. GDP-fucose transmembrane transporter activity Golgi apparatus membrane integral component of membrane GDP-fucose import into Golgi lumen uc008kyc.1 uc008kyc.2 uc008kyc.3 uc008kyc.4 
ENSMUST00000125277.2 Gm12730 ENSMUST00000125277.2 Gm12730 (from geneSymbol) ENSMUST00000125277.1 uc290ofz.1 uc290ofz.2 uc290ofz.1 uc290ofz.2 
ENSMUST00000125304.8 Lman2l ENSMUST00000125304.8 lectin, mannose-binding 2-like, transcript variant 2 (from RefSeq NM_001013374.2) ENSMUST00000125304.1 ENSMUST00000125304.2 ENSMUST00000125304.3 ENSMUST00000125304.4 ENSMUST00000125304.5 ENSMUST00000125304.6 ENSMUST00000125304.7 LMA2L_MOUSE NM_001013374 P59481 Q3TZ91 Vipl uc007aqd.1 uc007aqd.2 uc007aqd.3 uc007aqd.4 May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53 (By similarity). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Golgi apparatus membrane ; Single-pass type I membrane protein Note=Predominantly found in the endoplasmic reticulum. Partly found in the Golgi. Golgi membrane mannose binding endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus ER to Golgi vesicle-mediated transport endoplasmic reticulum organization Golgi organization protein transport membrane integral component of membrane ER to Golgi transport vesicle carbohydrate binding metal ion binding uc007aqd.1 uc007aqd.2 uc007aqd.3 uc007aqd.4 
ENSMUST00000125305.3 Evx1os ENSMUST00000125305.3 even skipped homeotic gene 1, opposite strand (from RefSeq NR_038163.1) ENSMUST00000125305.1 ENSMUST00000125305.2 NR_038163 uc009byu.1 uc009byu.2 uc009byu.3 uc009byu.1 uc009byu.2 uc009byu.3 
ENSMUST00000125307.2 Pld6 ENSMUST00000125307.2 phospholipase D family member 6, transcript variant 2 (from RefSeq NM_183139.2) B7ZN71 ENSMUST00000125307.1 NM_183139 PLD6_MOUSE Q3UTA3 Q5SWZ9 Q8BVM0 uc011xvp.1 uc011xvp.2 uc011xvp.3 Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3- phosphate), a second messenger signaling lipid. Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission. Both Lipin and DAG regulate mitochondrial dynamics and membrane fusion/fission, important processes for adapting mitochondrial metabolism to changes in cell physiology. Mitochondrial fusion enables cells to cope with the increased nucleotide demand during DNA synthesis (By similarity). Mitochondrial function and dynamics are closely associated with biological processes such as cell growth, proliferation, and differentiation (PubMed:21397848). Mediator of MYC activity, promotes mitochondrial fusion and activates AMPK which in turn inhibits YAP/TAZ, thereby inducing cell growth and proliferation (PubMed:26678338). The endonuclease activity plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis (PubMed:21397847, PubMed:21397848). Implicated in spermatogenesis and sperm fertility in testicular germ cells, its single strand-specific nuclease activity is critical for the biogenesis/maturation of PIWI-interacting RNA (piRNA) (PubMed:21397847, PubMed:23064230, PubMed:23064227). MOV10L1 selectively binds to piRNA precursors and funnels them to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). Cleaves either DNA or RNA substrates with similar affinity, producing a 5' phosphate end, in this way it participates in the processing of primary piRNA transcripts. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (PubMed:23064230, PubMed:23064227). PA may act as signaling molecule in the recognition/transport of the precursor RNAs of primary piRNAs (PubMed:21397847). Interacts with tesmin in testes, suggesting a role in spermatogenesis via association with its interacting partner (PubMed:33783608). Reaction=a cardiolipin + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn- glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+); Xref=Rhea:RHEA:44884, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58608, ChEBI:CHEBI:62237, ChEBI:CHEBI:64716; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44885; Evidence=; Single stranded DNA (ssDNA) hydrolase activity does not depend upon, but is stimulated by the presence of Ca(2+) and Mn(2+) (PubMed:23064227). MIGA1 and MIGA2 increase PLD6 self- association affinity and affects the homodimer conformation facilitating its phospholipase activity over the nuclease activity. MYC induces its expression and stimulates its phospholipase activity (By similarity). Homodimer (PubMed:23064227). Interacts with MOV10L1 (PubMed:25762440). Interacts with MIGA1 and MIGA2; possibly facilitating homodimer formation (By similarity). Interacts with GK2 (PubMed:28852571). Q5SWZ9-1; Q5SWZ9-1: Pld6; NbExp=3; IntAct=EBI-16017309, EBI-16017309; Mitochondrion outer membrane ; Single-pass membrane protein Nucleus membrane Cell membrane Golgi apparatus Note=Localization in the mitochondrial outer membrane is found in different cell types where phospholipase was the predominant activity, however, in pachytene spermatocytes and spermatids of mouse testes where nuclease activity is predominant, localization is restricted to the Golgi, suggesting this enzyme is localized in different subcellular compartments depending on the role (phospholipase or nuclease) it needs to play in each cell type and developmental stage. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SWZ9-1; Sequence=Displayed; Name=2; IsoId=Q5SWZ9-2; Sequence=VSP_032474, VSP_032475; Predominantly expressed in testis (at protein level) and in growing ovary (PubMed:21397847, PubMed:33783608). Also expressed in the brain, eye and urinary bladder (at protein level), but its levels were low or undetectable in other organs (PubMed:33783608). Expressed in embryonic testis at 16.5 dpc (at protein level). Expressed at low levels in type A and B spermatogonia, increases 5-fold in spermatocytes undergoing meiosis (pachytene spermatocytes), and then decreases again in round spermatids. Expressed at low levels in testes in young mice, peaks from postnatal day 14 to day 29 with the onset of puberty andpersists in adulthood (at protein level). In contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site. Males are sterile, because of meiotic arrest during spermatogenesis due to demethylation and subsequent derepression of transposable elements. No spermatids were observed in the mutant testes, and no spermatozoon in the epididymis. Effects are caused by defects in primary piRNA biogenesis: in contrast to wild-type cells neither mitochondria nor associated meiotic nuage (named P granule) are aggregated. Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily. Evidence for subcellular location in the Golgi was determined in pachytene spermatocytes and spermatids in mouse testes. They observe that the ectopically expressed PLD6 protein was localized to the mitochondria in PLD6-transfected cells. Authors claim a possible explanation for the contradictory results is that previous studies have reported the localization of exogenous PLD6, but not endogenous PLD6, in cultured cells. The reason for differences observed in subcellular localization of exogenous and endogenous PLD6 is not clear but one attributable reason may be that different types of anti-PLD6 antibodies have been used in previous studies. catalytic activity nuclease activity endonuclease activity protein binding mitochondrion mitochondrial outer membrane endoplasmic reticulum membrane lipid metabolic process spermatogenesis spermatid development mitochondrial fusion positive regulation of mitochondrial fusion membrane integral component of membrane lipid catabolic process hydrolase activity cell differentiation P granule organization piRNA metabolic process cardiolipin hydrolase activity identical protein binding protein homodimerization activity DNA methylation involved in gamete generation metal ion binding meiotic cell cycle nucleic acid phosphodiester bond hydrolysis uc011xvp.1 uc011xvp.2 uc011xvp.3 
ENSMUST00000125317.3 1700030A11Rik ENSMUST00000125317.3 RIKEN cDNA 1700030A11 gene (from RefSeq NR_045457.1) ENSMUST00000125317.1 ENSMUST00000125317.2 NR_045457 uc029tgq.1 uc029tgq.2 uc029tgq.3 uc029tgq.1 uc029tgq.2 uc029tgq.3 
ENSMUST00000125318.3 Gm28496 ENSMUST00000125318.3 Gm28496 (from geneSymbol) AK165177 ENSMUST00000125318.1 ENSMUST00000125318.2 uc291pdf.1 uc291pdf.2 uc291pdf.1 uc291pdf.2 
ENSMUST00000125333.3 Man2c1os ENSMUST00000125333.3 Man2c1os (from geneSymbol) AK077427 ENSMUST00000125333.1 ENSMUST00000125333.2 uc292hmp.1 uc292hmp.2 uc292hmp.1 uc292hmp.2 
ENSMUST00000125355.2 Gm14372 ENSMUST00000125355.2 predicted gene 14372, transcript variant 2 (from RefSeq NR_165255.1) ENSMUST00000125355.1 NR_165255 uc291xpl.1 uc291xpl.2 uc291xpl.1 uc291xpl.2 
ENSMUST00000125412.2 Gm12525 ENSMUST00000125412.2 Gm12525 (from geneSymbol) ENSMUST00000125412.1 uc290isb.1 uc290isb.2 uc290isb.1 uc290isb.2 
ENSMUST00000125484.3 Ighv13-2 ENSMUST00000125484.3 Ighv13-2 (from geneSymbol) A0A0A6YWN3 A0A0A6YWN3_MOUSE ENSMUST00000125484.1 ENSMUST00000125484.2 Ighv13-2 uc288jwr.1 uc288jwr.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jwr.1 uc288jwr.2 
ENSMUST00000125494.2 4930419G24Rik ENSMUST00000125494.2 RIKEN cDNA 4930419G24 gene (from RefSeq NR_040595.1) ENSMUST00000125494.1 NR_040595 uc008owy.1 uc008owy.2 uc008owy.1 uc008owy.2 
ENSMUST00000125538.9 2310065F04Rik ENSMUST00000125538.9 RIKEN cDNA 2310065F04 gene (from RefSeq NR_038055.1) ENSMUST00000125538.1 ENSMUST00000125538.2 ENSMUST00000125538.3 ENSMUST00000125538.4 ENSMUST00000125538.5 ENSMUST00000125538.6 ENSMUST00000125538.7 ENSMUST00000125538.8 NR_038055 uc007jma.1 uc007jma.2 uc007jma.3 uc007jma.1 uc007jma.2 uc007jma.3 
ENSMUST00000125541.2 Trnp1 ENSMUST00000125541.2 TMF1-regulated nuclear protein 1 (from RefSeq NM_001081156.2) ENSMUST00000125541.1 NM_001081156 Q80ZI1 TRNP1_MOUSE Trnp uc008vcu.1 uc008vcu.2 DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points. Interacts with TMF1; may regulate TRNP1 proteasomal degradation. Nucleus Expressed in brain and kidney (at protein level). Also detected in spleen and intestine. Expression is highly restricted to the phase of neurogenesis with high levels in all cells in the ventricular zone (VZ) at 10 dpc. Expression disappears at the end of neurogenesis (18 dpc). However, it remains present in a specific adult neurogenic region with the highest amplification and neuronal output, the subependymal zone of the lateral ventricle from where newborn neurons migrate to the olfactory bulb (at protein level). Ubiquitinated, leading to its degradation by the proteasome. Name=Protein Spotlight; Note=the geometry of intelligence - Issue 152 of August 2013; URL="https://web.expasy.org/spotlight/back_issues/152/"; DNA binding protein binding nucleus cell cycle multicellular organism development nervous system development cerebellar cortex morphogenesis regulation of cell proliferation regulation of cell cycle neural precursor cell proliferation nuclear euchromatin uc008vcu.1 uc008vcu.2 
ENSMUST00000125544.3 Gm20431 ENSMUST00000125544.3 Lipid metabolism; fatty acid metabolism. (from UniProt E9PY39) BC092253 E9PY39 E9PY39_MOUSE ENSMUST00000125544.1 ENSMUST00000125544.2 Gm20431 uc290ctg.1 uc290ctg.2 Lipid metabolism; fatty acid metabolism. Membrane ; Multi- pass membrane protein Belongs to the fatty acid desaturase CarF family. nucleus postreplication repair membrane integral component of membrane ubiquitin conjugating enzyme activity protein K63-linked ubiquitination uc290ctg.1 uc290ctg.2 
ENSMUST00000125575.2 Gm14100 ENSMUST00000125575.2 Gm14100 (from geneSymbol) ENSMUST00000125575.1 uc290ats.1 uc290ats.2 uc290ats.1 uc290ats.2 
ENSMUST00000125577.3 Gm11724 ENSMUST00000125577.3 Gm11724 (from geneSymbol) ENSMUST00000125577.1 ENSMUST00000125577.2 uc288dxk.1 uc288dxk.2 uc288dxk.3 uc288dxk.1 uc288dxk.2 uc288dxk.3 
ENSMUST00000125582.2 Gm13052 ENSMUST00000125582.2 Gm13052 (from geneSymbol) ENSMUST00000125582.1 uc290rll.1 uc290rll.2 uc290rll.1 uc290rll.2 
ENSMUST00000125600.2 Gm11426 ENSMUST00000125600.2 predicted gene 11426 (from RefSeq NR_033582.1) ENSMUST00000125600.1 NR_033582 uc007kmw.1 uc007kmw.2 uc007kmw.1 uc007kmw.2 
ENSMUST00000125607.2 Gm11725 ENSMUST00000125607.2 Gm11725 (from geneSymbol) AK090182 ENSMUST00000125607.1 uc288dyf.1 uc288dyf.2 uc288dyf.1 uc288dyf.2 
ENSMUST00000125609.2 Eif2c5l ENSMUST00000125609.2 Eif2c5l (from geneSymbol) AK090061 ENSMUST00000125609.1 uc009ulf.1 uc009ulf.2 uc009ulf.3 uc009ulf.1 uc009ulf.2 uc009ulf.3 
ENSMUST00000125611.8 Mecomos ENSMUST00000125611.8 Mecomos (from geneSymbol) AK145113 ENSMUST00000125611.1 ENSMUST00000125611.2 ENSMUST00000125611.3 ENSMUST00000125611.4 ENSMUST00000125611.5 ENSMUST00000125611.6 ENSMUST00000125611.7 uc008ouu.1 uc008ouu.2 uc008ouu.3 uc008ouu.1 uc008ouu.2 uc008ouu.3 
ENSMUST00000125626.2 E230016K23Rik ENSMUST00000125626.2 RIKEN cDNA E230016K23 gene, transcript variant 2 (from RefSeq NR_036453.1) ENSMUST00000125626.1 NR_036453 uc007kpk.1 uc007kpk.2 uc007kpk.3 uc007kpk.4 uc007kpk.1 uc007kpk.2 uc007kpk.3 uc007kpk.4 
ENSMUST00000125635.2 Gm48552 ENSMUST00000125635.2 Gm48552 (from geneSymbol) A0A1Y7VJ29 A0A1Y7VJ29_MOUSE AK080664 ENSMUST00000125635.1 Gm48552 uc287tiy.1 uc287tiy.2 monooxygenase activity membrane integral component of membrane oxidation-reduction process uc287tiy.1 uc287tiy.2 
ENSMUST00000125653.2 Ict1os ENSMUST00000125653.2 Ict1os (from geneSymbol) AK050600 ENSMUST00000125653.1 uc288dks.1 uc288dks.2 uc288dks.1 uc288dks.2 
ENSMUST00000125685.9 Fam169b ENSMUST00000125685.9 family with sequence similarity 169, member B, transcript variant 2 (from RefSeq NM_001013811.3) ENSMUST00000125685.1 ENSMUST00000125685.2 ENSMUST00000125685.3 ENSMUST00000125685.4 ENSMUST00000125685.5 ENSMUST00000125685.6 ENSMUST00000125685.7 ENSMUST00000125685.8 F169B_MOUSE NM_001013811 Q8CHT6 uc009hjf.1 uc009hjf.2 uc009hjf.3 uc009hjf.4 uc009hjf.5 Belongs to the FAM169 family. molecular_function cellular_component biological_process uc009hjf.1 uc009hjf.2 uc009hjf.3 uc009hjf.4 uc009hjf.5 
ENSMUST00000125704.8 Fam241b ENSMUST00000125704.8 family with sequence similarity 241, member B, transcript variant 1 (from RefSeq NM_027251.4) ENSMUST00000125704.1 ENSMUST00000125704.2 ENSMUST00000125704.3 ENSMUST00000125704.4 ENSMUST00000125704.5 ENSMUST00000125704.6 ENSMUST00000125704.7 F241B_MOUSE Fam241b NM_027251 Q9D882 uc007fgs.1 uc007fgs.2 uc007fgs.3 May play a role in lysosome homeostasis. Membrane ; Single-pass membrane protein Belongs to the FAM241 family. protein binding biological_process membrane integral component of membrane intracellular membrane-bounded organelle uc007fgs.1 uc007fgs.2 uc007fgs.3 
ENSMUST00000125721.8 Nfat5 ENSMUST00000125721.8 Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes (PubMed:11934689, PubMed:14983020). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (By similarity). Mediates the transcriptional response to hypertonicity (By similarity). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (By similarity). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (By similarity). (from UniProt Q9WV30) AF453571 E9Q0P3 E9Q6U2 ENSMUST00000125721.1 ENSMUST00000125721.2 ENSMUST00000125721.3 ENSMUST00000125721.4 ENSMUST00000125721.5 ENSMUST00000125721.6 ENSMUST00000125721.7 G5E8N9 NFAT5_MOUSE Q91WY0 Q9JLA1 Q9WV30 uc292daw.1 uc292daw.2 Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes (PubMed:11934689, PubMed:14983020). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (By similarity). Mediates the transcriptional response to hypertonicity (By similarity). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (By similarity). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (By similarity). Homodimer when bound to DNA, completely encircles its DNA target (By similarity). Interacts with CIDEC; this interaction is direct and retains NFAT5 in the cytoplasm (By similarity). Does not bind with Fos and Jun transcription factors. Interacts with DDX5 and DDX17; this interaction leads to DDX5/DDX17 recruitment to LNC2 and S100A4 promoters and NFAT5-mediated DDX5/DDX17-enhanced transactivation (By similarity). Nucleus toplasm Chromosome Note=Nuclear distribution increases under hypertonic conditions (PubMed:11934689). Recruited to sites of R-loop-associated DNA damage following poly-ADP-ribosylation by PARP1 (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=C; IsoId=Q9WV30-1; Sequence=Displayed; Name=2; Synonyms=D; IsoId=Q9WV30-2; Sequence=VSP_058790; Name=3; Synonyms=B; IsoId=Q9WV30-3; Sequence=VSP_058790, VSP_058791, VSP_058789; Name=4; IsoId=Q9WV30-4; Sequence=VSP_058792, VSP_058793; Detected in white and brown adipose tissue, muscle, heart, liver and kidney. Expressed in lymphocytes (at protein level). At 10.5 dpc, expressed in brain and developing lens. At 12.5 dpc, the expression is extended to liver. By 17.5 dpc, expressed abundantly in brain, spinal cord, heart end liver and moderately in salivary gland, lung, kidney, gut and bladder (at protein level). Up-regulated upon hypertonic conditions, this up-regulation in not observed in ES cells. Phosphorylated at Thr-135 by CDK5 in response to osmotic stress; this phosphorylation mediates its rapid nuclear localization. Poly-ADP-ribosylated by PARP1 in response to DNA damage, promoting recruitment to sites of R-loop-associated DNA damage. Embryonic and perinatal lethality with incomplete penetrance. At 17.5 dpc, 50% of the expected Mendelian rate with only 3.4% of the expected number living past 21 days after birth. The few survivors to adulthood fail to thrive and their weight is half compared to the wild-type. At 3 weeks old, kidney hypoplasia and an altered medullary morphology are observed with an increased apoptosis in the kidney inner medulla. Under osmotic stress, the transcriptional regulation of osmoprotective genes is altered in the kidney medulla. [Isoform 1]: May have longer half-life and is more efficient in stimulation of transcription than isoform 3. [Isoform 3]: The transcript encoding this isoform contains an alternative coding exon 4 which contains 2 stop codons and could target the transcript to nonsense-mediated mRNA decay after the pioneer round of translation, as suggested by decreased NFAT5 protein levels when the number of exon 4-containing transcripts increases. The insertion of exon 4 is stimulated in the presence of DDX5 and DDX17. Sequence=AAF31405.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAK97603.1; Type=Erroneous translation; Evidence=; Sequence=EDL11405.1; Type=Erroneous gene model prediction; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cytokine production DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor complex cytoplasm cytosol transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter response to osmotic stress transcription factor binding positive regulation of gene expression calcineurin-NFAT signaling cascade nuclear transcription factor complex positive regulation of transcription from RNA polymerase II promoter regulation of calcineurin-NFAT signaling cascade cellular response to cytokine stimulus positive regulation of NIK/NF-kappaB signaling positive regulation of leukocyte adhesion to vascular endothelial cell uc292daw.1 uc292daw.2 
ENSMUST00000125733.8 Ism2 ENSMUST00000125733.8 isthmin 2 (from RefSeq NM_001290302.1) D3Z6A3 D3Z6A3_MOUSE ENSMUST00000125733.1 ENSMUST00000125733.2 ENSMUST00000125733.3 ENSMUST00000125733.4 ENSMUST00000125733.5 ENSMUST00000125733.6 ENSMUST00000125733.7 Ism2 NM_001290302 uc056yrt.1 uc056yrt.2 Belongs to the isthmin family. molecular_function biological_process uc056yrt.1 uc056yrt.2 
ENSMUST00000125763.3 Zfp407 ENSMUST00000125763.3 zinc finger protein 407 (from RefSeq NM_001033341.2) ENSMUST00000125763.1 ENSMUST00000125763.2 G3UVV3 G3UVV3_MOUSE NM_001033341 Zfp407 uc008fuo.1 uc008fuo.2 uc008fuo.3 uc008fuo.4 uc008fuo.5 uc008fuo.6 Nucleus RNA polymerase II core promoter sequence-specific DNA binding nucleic acid binding zinc ion binding regulation of gene expression metal ion binding nucleus histone methyltransferase complex uc008fuo.1 uc008fuo.2 uc008fuo.3 uc008fuo.4 uc008fuo.5 uc008fuo.6 
ENSMUST00000125785.9 ENSMUSG00000121438 ENSMUST00000125785.9 ENSMUSG00000121438 (from geneSymbol) ENSMUST00000125785.1 ENSMUST00000125785.2 ENSMUST00000125785.3 ENSMUST00000125785.4 ENSMUST00000125785.5 ENSMUST00000125785.6 ENSMUST00000125785.7 ENSMUST00000125785.8 uc290rrt.1 uc290rrt.2 uc290rrt.3 uc290rrt.1 uc290rrt.2 uc290rrt.3 
ENSMUST00000125829.3 Gm15729 ENSMUST00000125829.3 Gm15729 (from geneSymbol) ENSMUST00000125829.1 ENSMUST00000125829.2 uc289ece.1 uc289ece.2 uc289ece.3 uc289ece.1 uc289ece.2 uc289ece.3 
ENSMUST00000125852.3 1700010K24Rik ENSMUST00000125852.3 1700010K24Rik (from geneSymbol) AK005839 ENSMUST00000125852.1 ENSMUST00000125852.2 uc008qyp.1 uc008qyp.2 uc008qyp.3 uc008qyp.4 uc008qyp.1 uc008qyp.2 uc008qyp.3 uc008qyp.4 
ENSMUST00000125853.2 Gm12316 ENSMUST00000125853.2 Gm12316 (from geneSymbol) ENSMUST00000125853.1 uc287zrg.1 uc287zrg.2 uc287zrg.1 uc287zrg.2 
ENSMUST00000125860.3 Bmf ENSMUST00000125860.3 BCL2 modifying factor, transcript variant 5 (from RefSeq NM_001424740.1) BMF_MOUSE ENSMUST00000125860.1 ENSMUST00000125860.2 NM_001424740 Q8BUK0 Q91ZE9 uc289zma.1 uc289zma.2 uc289zma.3 May play a role in apoptosis. Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2. Q91ZE9; Q07440: Bcl2a1; NbExp=2; IntAct=EBI-708032, EBI-707754; Q91ZE9; P10415: BCL2; Xeno; NbExp=2; IntAct=EBI-708032, EBI-77694; Q91ZE9; Q92843: BCL2L2; Xeno; NbExp=2; IntAct=EBI-708032, EBI-707714; Widely expressed with an abundant expression in pancreas, liver kidney and hematopoietic tissues. Belongs to the Bcl-2 family. Sequence=BAC39243.1; Type=Erroneous initiation; Evidence=; acrosomal vesicle protein binding cytoplasm apoptotic process cellular response to starvation negative regulation of autophagy actin cytoskeleton myosin complex positive regulation of protein complex assembly cellular response to UV positive regulation of apoptotic process anoikis positive regulation of release of cytochrome c from mitochondria negative regulation of autophagic cell death negative regulation of apoptotic signaling pathway positive regulation of apoptotic signaling pathway uc289zma.1 uc289zma.2 uc289zma.3 
ENSMUST00000125878.3 Spin2-ps9 ENSMUST00000125878.3 Spin2-ps9 (from geneSymbol) ENSMUST00000125878.1 ENSMUST00000125878.2 uc292mvl.1 uc292mvl.2 uc292mvl.3 uc292mvl.1 uc292mvl.2 uc292mvl.3 
ENSMUST00000125903.2 Gm16193 ENSMUST00000125903.2 predicted gene 16193 (from RefSeq NR_166600.1) ENSMUST00000125903.1 NR_166600 uc291zml.1 uc291zml.2 uc291zml.1 uc291zml.2 
ENSMUST00000125946.8 Gm42878 ENSMUST00000125946.8 Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (from UniProt A0A0G2JDU2) A0A0G2JDU2 A0A0G2JDU2_MOUSE AK137657 ENSMUST00000125946.1 ENSMUST00000125946.2 ENSMUST00000125946.3 ENSMUST00000125946.4 ENSMUST00000125946.5 ENSMUST00000125946.6 ENSMUST00000125946.7 Gm42878 uc290zfm.1 uc290zfm.2 Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. protein kinase activity ATP binding protein phosphorylation uc290zfm.1 uc290zfm.2 
ENSMUST00000125962.2 Gm12336 ENSMUST00000125962.2 Gm12336 (from geneSymbol) ENSMUST00000125962.1 uc288aes.1 uc288aes.2 uc288aes.1 uc288aes.2 
ENSMUST00000125965.8 Samd13 ENSMUST00000125965.8 sterile alpha motif domain containing 13, transcript variant 1 (from RefSeq NM_001368725.1) D3YUG0 ENSMUST00000125965.1 ENSMUST00000125965.2 ENSMUST00000125965.3 ENSMUST00000125965.4 ENSMUST00000125965.5 ENSMUST00000125965.6 ENSMUST00000125965.7 Gm1652 NM_001368725 SAM13_MOUSE uc290kkt.1 uc290kkt.2 molecular_function cellular_component biological_process uc290kkt.1 uc290kkt.2 
ENSMUST00000125993.8 Crxos ENSMUST00000125993.8 cone-rod homeobox, opposite strand, transcript variant 4 (from RefSeq NR_038092.2) ENSMUST00000125993.1 ENSMUST00000125993.2 ENSMUST00000125993.3 ENSMUST00000125993.4 ENSMUST00000125993.5 ENSMUST00000125993.6 ENSMUST00000125993.7 NR_038092 uc291lyr.1 uc291lyr.2 uc291lyr.1 uc291lyr.2 
ENSMUST00000126002.3 D930015M05Rik ENSMUST00000126002.3 RIKEN cDNA D930015M05 gene (from RefSeq NR_040621.1) ENSMUST00000126002.1 ENSMUST00000126002.2 NR_040621 uc029tzt.1 uc029tzt.2 uc029tzt.3 uc029tzt.1 uc029tzt.2 uc029tzt.3 
ENSMUST00000126008.8 Uxs1 ENSMUST00000126008.8 UDP-glucuronate decarboxylase 1, transcript variant 7 (from RefSeq NR_160751.1) ENSMUST00000126008.1 ENSMUST00000126008.2 ENSMUST00000126008.3 ENSMUST00000126008.4 ENSMUST00000126008.5 ENSMUST00000126008.6 ENSMUST00000126008.7 NR_160751 Q3U854 Q91XL3 UXS1_MOUSE uc007avq.1 uc007avq.2 uc007avq.3 Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. Reaction=H(+) + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose; Xref=Rhea:RHEA:23916, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57632, ChEBI:CHEBI:58052; EC=4.1.1.35; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23917; Evidence=; Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence=; Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1. Homodimer and homotetramer (By similarity). Interacts with AKT1 (By similarity). Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. cytoplasm mitochondrion Golgi apparatus membrane integral component of membrane lyase activity carboxy-lyase activity Golgi cisterna membrane UDP-D-xylose biosynthetic process protein homodimerization activity UDP-glucuronate decarboxylase activity protein tetramerization NAD+ binding uc007avq.1 uc007avq.2 uc007avq.3 
ENSMUST00000126011.2 Gm16336 ENSMUST00000126011.2 predicted gene 16336 (from RefSeq NR_045267.1) ENSMUST00000126011.1 NR_045267 uc029wnw.1 uc029wnw.2 uc029wnw.1 uc029wnw.2 
ENSMUST00000126025.2 Gm16126 ENSMUST00000126025.2 Gm16126 (from geneSymbol) ENSMUST00000126025.1 uc292jse.1 uc292jse.2 uc292jse.1 uc292jse.2 
ENSMUST00000126038.4 Or4p21 ENSMUST00000126038.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR17) ENSMUST00000126038.1 ENSMUST00000126038.2 ENSMUST00000126038.3 Olfr1182 Or4p21 Q7TR17 Q7TR17_MOUSE uc033hnz.1 uc033hnz.2 uc033hnz.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033hnz.1 uc033hnz.2 uc033hnz.3 
ENSMUST00000126071.9 Faf2 ENSMUST00000126071.9 Fas associated factor family member 2 (from RefSeq NM_178397.3) ENSMUST00000126071.1 ENSMUST00000126071.2 ENSMUST00000126071.3 ENSMUST00000126071.4 ENSMUST00000126071.5 ENSMUST00000126071.6 ENSMUST00000126071.7 ENSMUST00000126071.8 FAF2_MOUSE Kiaa0887 NM_178397 Q3TDN2 Q3U9W2 Q80TP7 Q80W42 Ubxd8 uc007qoq.1 uc007qoq.2 uc007qoq.3 Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady- state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. Involved in stress granule disassembly: associates with ubiquitinated G3BP1 in response to heat shock, thereby promoting interaction between ubiquitinated G3BP1 and VCP, followed by G3BP1 extraction from stress granules and stress granule disassembly. Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1. Interacts (via N-terminus) with UBQLN2 (via C-terminus). Interacts with PNPLA2 (By similarity). Interacts with ZFAND2B; probably through VCP (PubMed:24160817). Interacts with LMBR1L and UBAC2 (PubMed:31073040). Cytoplasm Lipid droplet Endoplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TDN2-1; Sequence=Displayed; Name=2; IsoId=Q3TDN2-2; Sequence=VSP_019504; cytoplasm endoplasmic reticulum lipid particle response to unfolded protein ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol ubiquitin protein ligase binding VCP-NPL4-UFD1 AAA ATPase complex lipid particle organization lipase binding negative regulation of catalytic activity ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process lipase inhibitor activity uc007qoq.1 uc007qoq.2 uc007qoq.3 
ENSMUST00000126077.8 Tbc1d14 ENSMUST00000126077.8 Tbc1d14 (from geneSymbol) BC011420 E9PYB1 E9PYB1_MOUSE ENSMUST00000126077.1 ENSMUST00000126077.2 ENSMUST00000126077.3 ENSMUST00000126077.4 ENSMUST00000126077.5 ENSMUST00000126077.6 ENSMUST00000126077.7 Tbc1d14 uc290uwb.1 uc290uwb.2 uc290uwb.1 uc290uwb.2 
ENSMUST00000126086.2 Gm16796 ENSMUST00000126086.2 predicted gene, 16796 (from RefSeq NR_040367.1) ENSMUST00000126086.1 NR_040367 uc029uik.1 uc029uik.2 uc029uik.1 uc029uik.2 
ENSMUST00000126114.9 Inca1 ENSMUST00000126114.9 inhibitor of CDK, cyclin A1 interacting protein 1, transcript variant 9 (from RefSeq NM_001419093.1) ENSMUST00000126114.1 ENSMUST00000126114.2 ENSMUST00000126114.3 ENSMUST00000126114.4 ENSMUST00000126114.5 ENSMUST00000126114.6 ENSMUST00000126114.7 ENSMUST00000126114.8 INCA1_MOUSE NM_001419093 Q4VAE2 Q6PKN7 uc029rmk.1 uc029rmk.2 Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and proliferation and may play a role in cell cycle control (PubMed:21540187). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (PubMed:21750715). Interacts with CCNA1 (PubMed:21540187). Identified in a complex with CCNA1 and CDK2 (By similarity). Interacts with ZNF16; the interaction inhibits INCA1 activity and induces the cell cycle process (By similarity). Interacts with SPACA9 (By similarity). Interacts with CCNA2, CCNB1 and CCNE1 (By similarity). Interacts with the CCNA1/CDK2 complex (PubMed:21540187). Interacts with ING5, DAZAP2, RNF26, USP15, SPOUT1, DPH7, TRIM26 and RAB5C (By similarity). Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PKN7-1; Sequence=Displayed; Name=2; IsoId=Q6PKN7-2; Sequence=VSP_033236; By serum starvation. Phosphorylated when part of a complex with CCNA1 and CDK2. Mice show increased CDK2 activity in spleen with disruption of the splenic architecture. Belongs to the INCA family. protein kinase inhibitor activity cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding nucleus nucleoplasm cytoplasm cell cycle negative regulation of cell proliferation nuclear body cyclin binding macromolecular complex binding negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of apoptotic signaling pathway uc029rmk.1 uc029rmk.2 
ENSMUST00000126122.3 Gm16159 ENSMUST00000126122.3 predicted gene 16159 (from RefSeq NR_110510.1) ENSMUST00000126122.1 ENSMUST00000126122.2 NR_110510 uc009lgd.1 uc009lgd.2 uc009lgd.3 uc009lgd.4 uc009lgd.1 uc009lgd.2 uc009lgd.3 uc009lgd.4 
ENSMUST00000126141.3 Gm13174 ENSMUST00000126141.3 Gm13174 (from geneSymbol) ENSMUST00000126141.1 ENSMUST00000126141.2 uc290sfy.1 uc290sfy.2 uc290sfy.3 uc290sfy.1 uc290sfy.2 uc290sfy.3 
ENSMUST00000126150.2 Pla2g4b ENSMUST00000126150.2 phospholipase A2, group IVB (cytosolic) (from RefSeq NM_145378.4) B7ZCM8 B7ZCM8_MOUSE ENSMUST00000126150.1 NM_145378 Pla2g4b uc012cbx.1 uc012cbx.2 uc012cbx.3 uc012cbx.4 Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Cytoplasm, cytosol The N-terminal C2 domain associates with lipid membranes upon calcium binding. phospholipase activity phospholipase A2 activity calcium ion binding cytoplasm lipid metabolic process phospholipid catabolic process lipid catabolic process hydrolase activity metal ion binding uc012cbx.1 uc012cbx.2 uc012cbx.3 uc012cbx.4 
ENSMUST00000126153.8 Katnal2 ENSMUST00000126153.8 katanin p60 subunit A-like 2, transcript variant 3 (from RefSeq NM_001368657.1) ENSMUST00000126153.1 ENSMUST00000126153.2 ENSMUST00000126153.3 ENSMUST00000126153.4 ENSMUST00000126153.5 ENSMUST00000126153.6 ENSMUST00000126153.7 KATL2_MOUSE NM_001368657 Q6NSQ2 Q9D3R6 uc008fqv.1 uc008fqv.2 uc008fqv.3 uc008fqv.4 Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence=; Cytoplasm, cytoskeleton toplasm Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D3R6-1; Sequence=Displayed; Name=2; IsoId=Q9D3R6-2; Sequence=VSP_033524, VSP_033525, VSP_033526; Name=3; IsoId=Q9D3R6-3; Sequence=VSP_033527, VSP_033528; Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily. nucleotide binding spindle pole ATP binding nucleus cytoplasm spindle cytoskeleton microtubule microtubule binding microtubule-severing ATPase activity isomerase activity ATPase activity cytoplasmic microtubule organization microtubule severing uc008fqv.1 uc008fqv.2 uc008fqv.3 uc008fqv.4 
ENSMUST00000126170.4 Gm36995 ENSMUST00000126170.4 Gm36995 (from geneSymbol) AK164582 ENSMUST00000126170.1 ENSMUST00000126170.2 ENSMUST00000126170.3 uc292mww.1 uc292mww.2 uc292mww.1 uc292mww.2 
ENSMUST00000126187.2 Gm11751 ENSMUST00000126187.2 Gm11751 (from geneSymbol) ENSMUST00000126187.1 uc290nft.1 uc290nft.2 uc290nft.1 uc290nft.2 
ENSMUST00000126189.3 Msantd5 ENSMUST00000126189.3 Myb/SANT DNA binding domain containing 5, transcript variant 4 (from RefSeq NM_001378504.1) A0A338P6G8 A0A338P6G8_MOUSE ENSMUST00000126189.1 ENSMUST00000126189.2 Gm12569 Msantd5 NM_001378504 uc287xyq.1 uc287xyq.2 uc287xyq.1 uc287xyq.2 
ENSMUST00000126212.2 Gm13093 ENSMUST00000126212.2 Gm13093 (from geneSymbol) AK081620 ENSMUST00000126212.1 uc290rzy.1 uc290rzy.2 uc290rzy.1 uc290rzy.2 
ENSMUST00000126214.8 Ccser1 ENSMUST00000126214.8 coiled-coil serine rich 1, transcript variant 1 (from RefSeq NM_183310.2) CCSE1_MOUSE ENSMUST00000126214.1 ENSMUST00000126214.2 ENSMUST00000126214.3 ENSMUST00000126214.4 ENSMUST00000126214.5 ENSMUST00000126214.6 ENSMUST00000126214.7 Fam190a Kiaa1680 NM_183310 Q3KN97 Q69ZD5 Q8C0C4 Q8C822 uc009cdw.1 uc009cdw.2 uc009cdw.3 uc009cdw.4 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C0C4-1; Sequence=Displayed; Name=2; IsoId=Q8C0C4-2; Sequence=VSP_035320, VSP_035321; Name=3; IsoId=Q8C0C4-3; Sequence=VSP_035322, VSP_035323; Belongs to the CCSER family. Sequence=BAD32509.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc009cdw.1 uc009cdw.2 uc009cdw.3 uc009cdw.4 
ENSMUST00000126225.2 Bach2os ENSMUST00000126225.2 BTB and CNC homology 2, opposite strand (from RefSeq NR_026843.1) ENSMUST00000126225.1 NR_026843 uc008set.1 uc008set.2 uc008set.3 uc008set.1 uc008set.2 uc008set.3 
ENSMUST00000126240.2 Gm13613 ENSMUST00000126240.2 Gm13613 (from geneSymbol) BC046451 ENSMUST00000126240.1 uc289wqq.1 uc289wqq.2 uc289wqq.1 uc289wqq.2 
ENSMUST00000126245.2 Msto1 ENSMUST00000126245.2 misato 1, mitochondrial distribution and morphology regulator (from RefSeq NM_144898.2) E9PUB7 E9PUB7_MOUSE ENSMUST00000126245.1 Msto1 NM_144898 uc008pxe.1 uc008pxe.2 uc008pxe.3 uc008pxe.4 Mitochondrion outer membrane Belongs to the misato family. cytoplasm mitochondrial outer membrane mitochondrion organization mitochondrion distribution uc008pxe.1 uc008pxe.2 uc008pxe.3 uc008pxe.4 
ENSMUST00000126260.2 4930554G24Rik ENSMUST00000126260.2 RIKEN cDNA 4930554G24 gene (from RefSeq NR_131011.1) ENSMUST00000126260.1 NR_131011 uc056yju.1 uc056yju.2 uc056yju.1 uc056yju.2 
ENSMUST00000126270.2 Gm12648 ENSMUST00000126270.2 Gm12648 (from geneSymbol) AK144572 ENSMUST00000126270.1 uc290nue.1 uc290nue.2 uc290nue.1 uc290nue.2 
ENSMUST00000126294.2 Gm12756 ENSMUST00000126294.2 Gm12756 (from geneSymbol) ENSMUST00000126294.1 uc291olh.1 uc291olh.2 uc291olh.1 uc291olh.2 
ENSMUST00000126314.2 Gm12381 ENSMUST00000126314.2 predicted gene 12381 (from RefSeq NR_151606.1) ENSMUST00000126314.1 NR_151606 uc290lua.1 uc290lua.2 uc290lua.1 uc290lua.2 
ENSMUST00000126319.8 Tbl3 ENSMUST00000126319.8 transducin (beta)-like 3 (from RefSeq NM_145396.4) ENSMUST00000126319.1 ENSMUST00000126319.2 ENSMUST00000126319.3 ENSMUST00000126319.4 ENSMUST00000126319.5 ENSMUST00000126319.6 ENSMUST00000126319.7 NM_145396 Q3TNP3 Q3UDS9 Q8C4J7 Q8VE90 TBL3_MOUSE uc008axv.1 uc008axv.2 uc008axv.3 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleus nucleolus rRNA processing small-subunit processome Pwp2p-containing subcomplex of 90S preribosome uc008axv.1 uc008axv.2 uc008axv.3 
ENSMUST00000126326.2 Gm13837 ENSMUST00000126326.2 Gm13837 (from geneSymbol) ENSMUST00000126326.1 uc290ywt.1 uc290ywt.2 uc290ywt.1 uc290ywt.2 
ENSMUST00000126339.9 Platr21 ENSMUST00000126339.9 pluripotency associated transcript 21, transcript variant 1 (from RefSeq NR_045455.1) ENSMUST00000126339.1 ENSMUST00000126339.2 ENSMUST00000126339.3 ENSMUST00000126339.4 ENSMUST00000126339.5 ENSMUST00000126339.6 ENSMUST00000126339.7 ENSMUST00000126339.8 NR_045455 uc009ukd.1 uc009ukd.2 uc009ukd.1 uc009ukd.2 
ENSMUST00000126358.9 Gm14419 ENSMUST00000126358.9 Gm14419 (from geneSymbol) A2ARL5 A2ARL5_MOUSE AK005481 ENSMUST00000126358.1 ENSMUST00000126358.2 ENSMUST00000126358.3 ENSMUST00000126358.4 ENSMUST00000126358.5 ENSMUST00000126358.6 ENSMUST00000126358.7 ENSMUST00000126358.8 Gm14419 Gm2004 uc290dfe.1 uc290dfe.2 uc290dfe.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc290dfe.1 uc290dfe.2 uc290dfe.3 
ENSMUST00000126388.8 Slc16a11 ENSMUST00000126388.8 Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids. (from UniProt Q5NC32) A2BDD4 AB041591 ENSMUST00000126388.1 ENSMUST00000126388.2 ENSMUST00000126388.3 ENSMUST00000126388.4 ENSMUST00000126388.5 ENSMUST00000126388.6 ENSMUST00000126388.7 MOT11_MOUSE Mct11 Q5NC32 Q5NC33 uc287zon.1 uc287zon.2 Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids. Reaction=H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in); Xref=Rhea:RHEA:64720, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378; Evidence=; Interacts with isoform 2 of BSG. Endoplasmic reticulum membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. Sequence=AAI30256.1; Type=Erroneous initiation; Evidence=; Sequence=CAI35219.2; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM28086.1; Type=Erroneous gene model prediction; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane lipid metabolic process monocarboxylic acid transmembrane transporter activity symporter activity monocarboxylic acid transport membrane integral component of membrane pyruvate transmembrane transporter activity transmembrane transport pyruvate transmembrane transport uc287zon.1 uc287zon.2 
ENSMUST00000126390.8 Reps1 ENSMUST00000126390.8 RalBP1 associated Eps domain containing protein, transcript variant 1 (from RefSeq NM_009048.3) ENSMUST00000126390.1 ENSMUST00000126390.2 ENSMUST00000126390.3 ENSMUST00000126390.4 ENSMUST00000126390.5 ENSMUST00000126390.6 ENSMUST00000126390.7 NM_009048 O54916 Q3UAM3 Q5PPQ9 Q8C9J9 Q99LR8 REPS1_MOUSE uc007ema.1 uc007ema.2 uc007ema.3 uc007ema.4 May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. Homodimer (Potential). Interacts with RALBP1, CRK and GRB2. Binding to RALBP1 does not affect its Ral-binding activity. Forms a complex with the SH3 domains of CRK and GRB2 which may link it to an EGF-responsive tyrosine kinase. Interacts with RAB11FIP2 (By similarity). Interacts with AMPH, ITSN1 (via SH3 domains) and SGIP1; may be involved in clathrin-mediated endocytosis (By similarity). Membrane, clathrin-coated pit Note=Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O54916-1; Sequence=Displayed; Name=2; IsoId=O54916-2; Sequence=VSP_038337, VSP_007956, VSP_007957; Name=3; IsoId=O54916-3; Sequence=VSP_038336, VSP_038338; Name=4; IsoId=O54916-4; Sequence=VSP_038336; Expressed in all tissues examined. The highest level expression was found in the kidney and testis. EGF stimulates phosphorylation on Tyr-residues. [Isoform 2]: Due to intron retention. Sequence=BAE29439.1; Type=Erroneous initiation; Evidence=; Sequence=BAE30291.1; Type=Erroneous initiation; Evidence=; calcium ion binding protein binding plasma membrane clathrin-coated pit receptor-mediated endocytosis membrane SH3 domain binding metal ion binding uc007ema.1 uc007ema.2 uc007ema.3 uc007ema.4 
ENSMUST00000126395.3 Spin2-ps4 ENSMUST00000126395.3 Spin2-ps4 (from geneSymbol) ENSMUST00000126395.1 ENSMUST00000126395.2 uc292pba.1 uc292pba.2 uc292pba.3 uc292pba.1 uc292pba.2 uc292pba.3 
ENSMUST00000126401.2 Gm13716 ENSMUST00000126401.2 Gm13716 (from geneSymbol) ENSMUST00000126401.1 uc289xoa.1 uc289xoa.2 uc289xoa.1 uc289xoa.2 
ENSMUST00000126435.8 Mri1 ENSMUST00000126435.8 methylthioribose-1-phosphate isomerase 1 (from RefSeq NM_026423.4) ENSMUST00000126435.1 ENSMUST00000126435.2 ENSMUST00000126435.3 ENSMUST00000126435.4 ENSMUST00000126435.5 ENSMUST00000126435.6 ENSMUST00000126435.7 MTNA_MOUSE NM_026423 Q8BXF6 Q9CQT1 uc009mmi.1 uc009mmi.2 uc009mmi.3 uc009mmi.4 Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Reaction=S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio- D-ribulose 1-phosphate; Xref=Rhea:RHEA:19989, ChEBI:CHEBI:58533, ChEBI:CHEBI:58548; EC=5.3.1.23; Evidence= Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. Cytoplasm Nucleus Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. fibrillar center nucleus nucleoplasm cytoplasm cytosol cellular amino acid biosynthetic process methionine biosynthetic process isomerase activity L-methionine biosynthetic process from S-adenosylmethionine L-methionine biosynthetic process from methylthioadenosine identical protein binding cellular metabolic process cellular biosynthetic process S-methyl-5-thioribose-1-phosphate isomerase activity uc009mmi.1 uc009mmi.2 uc009mmi.3 uc009mmi.4 
ENSMUST00000126498.3 Gm13856 ENSMUST00000126498.3 Gm13856 (from geneSymbol) AK015572 ENSMUST00000126498.1 ENSMUST00000126498.2 uc291dkf.1 uc291dkf.2 uc291dkf.3 uc291dkf.1 uc291dkf.2 uc291dkf.3 
ENSMUST00000126521.9 Spx ENSMUST00000126521.9 spexin hormone, transcript variant 1 (from RefSeq NM_001242345.1) A0A1C7CYU9 A0A1C7CYU9_MOUSE ENSMUST00000126521.1 ENSMUST00000126521.2 ENSMUST00000126521.3 ENSMUST00000126521.4 ENSMUST00000126521.5 ENSMUST00000126521.6 ENSMUST00000126521.7 ENSMUST00000126521.8 NM_001242345 Spx uc033ivv.1 uc033ivv.2 uc033ivv.3 Cytoplasmic vesicle, secretory vesicle Secreted, extracellular space Belongs to the spexin family. neuropeptide hormone activity extracellular space signal transduction dense core granule positive regulation of gastro-intestinal system smooth muscle contraction uc033ivv.1 uc033ivv.2 uc033ivv.3 
ENSMUST00000126532.2 Heg1 ENSMUST00000126532.2 Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May be acting by stabilizing endothelial cell junctions. (from UniProt E9Q7X6) BC076596 E9Q7X6 ENSMUST00000126532.1 HEG1_MOUSE Q3TR26 Q6GQS6 Q8CED0 uc289egr.1 uc289egr.2 Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May be acting by stabilizing endothelial cell junctions. Interacts with CCM2 and KRIT1; KRIT1 markedly facilitates interaction with CCM2. Cell membrane ; Single-pass type I membrane protein Cell junction Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=E9Q7X6-1; Sequence=Displayed; Name=2; IsoId=E9Q7X6-2; Sequence=VSP_042234; Name=3; IsoId=E9Q7X6-3; Sequence=VSP_042234, VSP_042235, VSP_042236; Expressed in the endothelium of the developing heart and aorta and in the neural tube at 10.5 dpc, and in the arterial endothelium, smooth muscle, endocardium of the heart and brain vasculature at 14.5 dpc. Some mutant animals die in utero, but most die postnatally, about half before weaning as a result of pulmonary hemorrhage. Midgestation mutant embryos show cardiac defects characterized by invagination of the ventricular cavity into, and often through, the compact layer of ventricular myocardium. The septal myocardium is similarly honeycombed by endothelial-lined extensions from the ventricular cavity, a defect accompanied by the presence of ventricular septal defects in most late-gestation embryos. Neonatal mice also show defective cardiac integrity manifested by a blood-filled pericardial sac, due to the rupture of the low-pressure atrial chamber of the heart. Cardiac or pulmonary integrity defects are observed in half of the animals. About 10% of neonatal mutant mice exhibit dilated lymphatic vessel malformations. [Isoform 3]: May be due to an intron retention. Sequence=AAH72651.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; vasculogenesis in utero embryonic development endothelial cell development endothelial cell morphogenesis vasculature development lymph vessel development lymph circulation cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis ventricular septum development calcium ion binding protein binding plasma membrane cell-cell junction cell-cell junction assembly multicellular organism development heart development post-embryonic development external side of plasma membrane cell surface membrane integral component of membrane cell junction lung development negative regulation of Rho protein signal transduction multicellular organism growth cell-cell junction organization venous blood vessel morphogenesis regulation of body fluid levels cardiac muscle tissue growth pericardium development positive regulation of fibroblast growth factor production protein localization to cell junction negative regulation of membrane permeability negative regulation of Rho-dependent protein serine/threonine kinase activity uc289egr.1 uc289egr.2 
ENSMUST00000126534.8 Ucp2 ENSMUST00000126534.8 uncoupling protein 2 (mitochondrial, proton carrier), transcript variant 7 (from RefSeq NR_184452.1) ENSMUST00000126534.1 ENSMUST00000126534.2 ENSMUST00000126534.3 ENSMUST00000126534.4 ENSMUST00000126534.5 ENSMUST00000126534.6 ENSMUST00000126534.7 NR_184452 Q549J5 Q549J5_MOUSE UCP2 Ucp2 uc009inb.1 uc009inb.2 uc009inb.3 uc009inb.4 uc009inb.5 Reaction=(S)-malate(out) + H(+)(in) + phosphate(in) = (S)-malate(in) + H(+)(out) + phosphate(out); Xref=Rhea:RHEA:73299, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589, ChEBI:CHEBI:43474; Evidence=; Reaction=(S)-malate(out) = (S)-malate(in); Xref=Rhea:RHEA:74555, ChEBI:CHEBI:15589; Evidence=; Reaction=H(+)(in) + L-aspartate(out) + phosphate(in) = H(+)(out) + L- aspartate(in) + phosphate(out); Xref=Rhea:RHEA:73307, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:43474; Evidence=; Reaction=H(+)(in) + malonate(out) + phosphate(in) = H(+)(out) + malonate(in) + phosphate(out); Xref=Rhea:RHEA:73387, ChEBI:CHEBI:15378, ChEBI:CHEBI:15792, ChEBI:CHEBI:43474; Evidence=; Reaction=H(+)(in) + oxaloacetate(out) + phosphate(in) = H(+)(out) + oxaloacetate(in) + phosphate(out); Xref=Rhea:RHEA:73303, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:43474; Evidence=; Reaction=H(+)(in) + phosphate(in) + sulfate(out) = H(+)(out) + phosphate(out) + sulfate(in); Xref=Rhea:RHEA:73391, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:43474; Evidence=; Reaction=H(+)(in) = H(+)(out); Xref=Rhea:RHEA:34979, ChEBI:CHEBI:15378; Evidence=; Reaction=L-aspartate(out) = L-aspartate(in); Xref=Rhea:RHEA:66332, ChEBI:CHEBI:29991; Evidence=; Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; Reaction=phosphate(in) = phosphate(out); Xref=Rhea:RHEA:32823, ChEBI:CHEBI:43474; Evidence=; Homotetramer. Adopts an asymmetrical dimer of dimers functional form. Membrane ; Multi- pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. response to superoxide response to hypoxia cytoplasm mitochondrion mitochondrial transport female pregnancy aging response to glucose positive regulation of cell death membrane integral component of membrane mitochondrial membrane cellular response to insulin stimulus cellular response to hormone stimulus cellular response to amino acid starvation negative regulation of apoptotic process negative regulation of insulin secretion involved in cellular response to glucose stimulus response to fatty acid cellular response to glucose stimulus liver regeneration uc009inb.1 uc009inb.2 uc009inb.3 uc009inb.4 uc009inb.5 
ENSMUST00000126572.2 Gm13944 ENSMUST00000126572.2 predicted gene 13944 (from RefSeq NR_040368.1) ENSMUST00000126572.1 NR_040368 uc289xfg.1 uc289xfg.2 uc289xfg.1 uc289xfg.2 
ENSMUST00000126587.2 Gm20479 ENSMUST00000126587.2 Gm20479 (from geneSymbol) BC061477 D3Z4P8 D3Z4P8_MOUSE ENSMUST00000126587.1 Gm20479 Shkbp1 uc291nfn.1 uc291nfn.2 uc291nfn.1 uc291nfn.2 
ENSMUST00000126596.2 A230059L01Rik ENSMUST00000126596.2 A230059L01Rik (from geneSymbol) AK033458 ENSMUST00000126596.1 uc287mjr.1 uc287mjr.2 uc287mjr.1 uc287mjr.2 
ENSMUST00000126610.2 Rpl12 ENSMUST00000126610.2 ribosomal protein L12 (from RefSeq NM_009076.3) ENSMUST00000126610.1 NM_009076 Q5BLK0 Q5BLK0_MOUSE Rpl12 uc008jhe.1 uc008jhe.2 uc008jhe.3 uc008jhe.4 Binds directly to 26S ribosomal RNA. Belongs to the universal ribosomal protein uL11 family. structural constituent of ribosome ribosome translation postsynaptic density uc008jhe.1 uc008jhe.2 uc008jhe.3 uc008jhe.4 
ENSMUST00000126621.3 Gm42420 ENSMUST00000126621.3 Gm42420 (from geneSymbol) A0A0J9YUQ2 A0A0J9YUQ2_MOUSE AK028568 ENSMUST00000126621.1 ENSMUST00000126621.2 Gm42420 uc291drx.1 uc291drx.2 uc291drx.1 uc291drx.2 
ENSMUST00000126640.2 Gm15288 ENSMUST00000126640.2 Gm15288 (from geneSymbol) ENSMUST00000126640.1 uc288pxk.1 uc288pxk.2 uc288pxk.1 uc288pxk.2 
ENSMUST00000126646.3 A230083N12Rik ENSMUST00000126646.3 A230083N12Rik (from geneSymbol) ENSMUST00000126646.1 ENSMUST00000126646.2 KY467984 uc290nig.1 uc290nig.2 uc290nig.3 uc290nig.1 uc290nig.2 uc290nig.3 
ENSMUST00000126656.4 Efcab8 ENSMUST00000126656.4 EF-hand calcium binding domain 8 (from RefSeq NM_001370916.1) ENSMUST00000126656.1 ENSMUST00000126656.2 ENSMUST00000126656.3 Efcab8 H3BL58 H3BL58_MOUSE NM_001370916 uc290bne.1 uc290bne.2 calcium ion binding uc290bne.1 uc290bne.2 
ENSMUST00000126658.9 Lrrc31 ENSMUST00000126658.9 leucine rich repeat containing 31 (from RefSeq NM_001309233.1) ENSMUST00000126658.1 ENSMUST00000126658.2 ENSMUST00000126658.3 ENSMUST00000126658.4 ENSMUST00000126658.5 ENSMUST00000126658.6 ENSMUST00000126658.7 ENSMUST00000126658.8 F6VYM1 F6VYM1_MOUSE Lrrc31 NM_001309233 uc290ehp.1 uc290ehp.2 uc290ehp.3 molecular_function cellular_component biological_process uc290ehp.1 uc290ehp.2 uc290ehp.3 
ENSMUST00000126659.2 Gm13388 ENSMUST00000126659.2 Gm13388 (from geneSymbol) ENSMUST00000126659.1 uc289suv.1 uc289suv.2 uc289suv.1 uc289suv.2 
ENSMUST00000126662.2 Gm21974 ENSMUST00000126662.2 Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt F6W3F3) BC147509 ENSMUST00000126662.1 F6W3F3 F6W3F3_MOUSE Gm21974 Vkorc1 uc291vyv.1 uc291vyv.2 Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the VKOR family. blood coagulation membrane integral component of membrane peptidyl-glutamic acid carboxylation vitamin K metabolic process vitamin-K-epoxide reductase (warfarin-sensitive) activity oxidation-reduction process uc291vyv.1 uc291vyv.2 
ENSMUST00000126664.8 Atp10d ENSMUST00000126664.8 ATPase, class V, type 10D, transcript variant 1 (from RefSeq NR_003966.1) ENSMUST00000126664.1 ENSMUST00000126664.2 ENSMUST00000126664.3 ENSMUST00000126664.4 ENSMUST00000126664.5 ENSMUST00000126664.6 ENSMUST00000126664.7 NR_003966 uc057lmi.1 uc057lmi.2 uc057lmi.3 uc057lmi.1 uc057lmi.2 uc057lmi.3 
ENSMUST00000126668.2 Gm12743 ENSMUST00000126668.2 Gm12743 (from geneSymbol) AK054420 ENSMUST00000126668.1 uc008ubk.1 uc008ubk.2 uc008ubk.1 uc008ubk.2 
ENSMUST00000126677.3 Gm15537 ENSMUST00000126677.3 Gm15537 (from geneSymbol) ENSMUST00000126677.1 ENSMUST00000126677.2 uc289cat.1 uc289cat.2 uc289cat.3 uc289cat.1 uc289cat.2 uc289cat.3 
ENSMUST00000126693.3 Gm15498 ENSMUST00000126693.3 predicted gene 15498 (from RefSeq NR_188387.1) ENSMUST00000126693.1 ENSMUST00000126693.2 NR_188387 uc009adp.1 uc009adp.2 uc009adp.3 uc009adp.4 uc009adp.1 uc009adp.2 uc009adp.3 uc009adp.4 
ENSMUST00000126711.2 Gm14553 ENSMUST00000126711.2 Gm14553 (from geneSymbol) AK135675 ENSMUST00000126711.1 uc009sxe.1 uc009sxe.2 uc009sxe.3 uc009sxe.1 uc009sxe.2 uc009sxe.3 
ENSMUST00000126712.8 Gm3669 ENSMUST00000126712.8 Gm3669 (from geneSymbol) AK139882 ENSMUST00000126712.1 ENSMUST00000126712.2 ENSMUST00000126712.3 ENSMUST00000126712.4 ENSMUST00000126712.5 ENSMUST00000126712.6 ENSMUST00000126712.7 uc009swj.1 uc009swj.2 uc009swj.1 uc009swj.2 
ENSMUST00000126798.9 Snhg7os ENSMUST00000126798.9 Snhg7os (from geneSymbol) AK030770 ENSMUST00000126798.1 ENSMUST00000126798.2 ENSMUST00000126798.3 ENSMUST00000126798.4 ENSMUST00000126798.5 ENSMUST00000126798.6 ENSMUST00000126798.7 ENSMUST00000126798.8 uc289ufz.1 uc289ufz.2 uc289ufz.3 uc289ufz.1 uc289ufz.2 uc289ufz.3 
ENSMUST00000126849.3 Gm15558 ENSMUST00000126849.3 Gm15558 (from geneSymbol) AK134234 ENSMUST00000126849.1 ENSMUST00000126849.2 uc029swb.1 uc029swb.2 uc029swb.3 uc029swb.1 uc029swb.2 uc029swb.3 
ENSMUST00000126854.9 Rapgef3 ENSMUST00000126854.9 Rap guanine nucleotide exchange factor (GEF) 3, transcript variant 4 (from RefSeq NM_001357630.1) ENSMUST00000126854.1 ENSMUST00000126854.2 ENSMUST00000126854.3 ENSMUST00000126854.4 ENSMUST00000126854.5 ENSMUST00000126854.6 ENSMUST00000126854.7 ENSMUST00000126854.8 Epac Epac1 NM_001357630 Q8BZK9 Q8R1R1 Q8VCC8 RPGF3_MOUSE uc007xkz.1 uc007xkz.2 uc007xkz.3 uc007xkz.4 Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP- induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin (By similarity). Interacts with PDE3B and PIK3R6; form a signaling complex that regulates phosphatidylinositol 3-kinase gamma in angiogenesis. Q8VCC8; E9Q9K8: Akap6; NbExp=2; IntAct=EBI-6902706, EBI-6902745; Cytoplasm. Membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VCC8-1; Sequence=Displayed; Name=2; IsoId=Q8VCC8-2; Sequence=VSP_007610; The DEP domain is involved in membrane localization independent from regulation by cAMP. It is uncertain whether Met-1 or Met-43 is the initiator. Sequence=AAH20532.1; Type=Erroneous initiation; Evidence=; nucleotide binding angiogenesis positive regulation of protein phosphorylation guanyl-nucleotide exchange factor activity protein binding cytoplasm plasma membrane microvillus small GTPase mediated signal transduction basal plasma membrane negative regulation of cardiac muscle cell apoptotic process positive regulation of smooth muscle cell migration membrane Rap guanyl-nucleotide exchange factor activity protein domain specific binding lamellipodium filopodium growth cone cAMP binding cortical actin cytoskeleton organelle membrane brush border membrane Rap protein signal transduction negative regulation of collagen biosynthetic process positive regulation of peptidyl-serine phosphorylation negative regulation of syncytium formation by plasma membrane fusion intracellular signal transduction neuronal cell body positive regulation of GTPase activity axon terminus ion channel binding apical part of cell positive regulation of angiogenesis positive regulation of cell size positive regulation of transcription from RNA polymerase II promoter positive regulation of protein export from nucleus perinuclear region of cytoplasm positive regulation of stress fiber assembly positive regulation of syncytium formation by plasma membrane fusion establishment of endothelial barrier cellular response to cAMP cell periphery ribbon synapse positive regulation of protein acetylation positive regulation of GTP binding positive regulation of calcium ion transmembrane transport positive regulation of hydrogen:potassium-exchanging ATPase activity basolateral part of cell rod bipolar cell terminal bouton photoreceptor cell terminal bouton regulation of actin cytoskeleton reorganization positive regulation of actin cytoskeleton reorganization uc007xkz.1 uc007xkz.2 uc007xkz.3 uc007xkz.4 
ENSMUST00000126865.8 Sik3 ENSMUST00000126865.8 SIK family kinase 3 (from RefSeq NM_027498.3) E9PU87 ENSMUST00000126865.1 ENSMUST00000126865.2 ENSMUST00000126865.3 ENSMUST00000126865.4 ENSMUST00000126865.5 ENSMUST00000126865.6 ENSMUST00000126865.7 Kiaa0999 NM_027498 Q641L5 Q66JZ5 Q6P4S6 Q6ZQ09 Q8K075 Q9CYD5 Qsk SIK3_MOUSE uc009pgz.1 uc009pgz.2 uc009pgz.3 Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor (By similarity). Required for chondrocyte hypertrophy during skeletogenesis (PubMed:22318228). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (By similarity). Prevents HDAC4 translocation to the nucleus (PubMed:22318228). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation on Thr-221. Binds to and is activated by YWHAZ when phosphorylated on Thr- 221 (By similarity). Interacts with 14-3-3 proteins (By similarity). Interacts with HDAC4; this interaction leads to HDAC4 retention in the cytoplasm (PubMed:22318228). Interacts with DEPTOR, MLST8/GbetaL, RICTOR and RPTOR (By similarity). Cytoplasm Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P4S6-1; Sequence=Displayed; Name=2; IsoId=Q6P4S6-2; Sequence=VSP_020894, VSP_020895; Expressed in hypertrophic chondrocytes in the growth plate. In the embryo, detected at 15.5 dpc in both prehypertrophic and hypertrophic chondrocytes in developing bones (PubMed:22318228). At postnatal day 1 (P1), in cartilage growth plate, expressed in early proliferating and prehypertrophic chondrocytes. This expression pattern is maintained at least until P21 (at protein level) (PubMed:30232230). Phosphorylated at Thr-221 by STK11/LKB1 in complex with STE20- related adapter-alpha (STRADA) pseudo kinase and CAB39. Mutant mice are born at the expected Mendelian rate, but 90% die on the first day after birth. The surviving animals show dwarfism throughout their postnatal life. They exhibit marked expansion of the growth plate and articular cartilage regions in the limbs, accumulation of chondrocytes in the sternum, ribs and spine, and impaired skull bone formation. Although chondrocyte hypertrophy and bone mineralization are markedly delayed, the body size is unaffected during embryogenesis, dwarfism appears as animals age. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. [Isoform 1]: Sequence=AAH63268.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH80688.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH82313.1; Type=Frameshift; Evidence=; nucleotide binding microtubule cytoskeleton organization magnesium ion binding endochondral ossification protein kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity regulation of protein localization limb morphogenesis multicellular organism growth intracellular signal transduction metal ion binding skeletal system morphogenesis tau-protein kinase activity cartilage development involved in endochondral bone morphogenesis positive regulation of TORC1 signaling positive regulation of TORC2 signaling uc009pgz.1 uc009pgz.2 uc009pgz.3 
ENSMUST00000126879.8 Zfp369 ENSMUST00000126879.8 zinc finger protein 369 (from RefSeq NM_178364.5) ENSMUST00000126879.1 ENSMUST00000126879.2 ENSMUST00000126879.3 ENSMUST00000126879.4 ENSMUST00000126879.5 ENSMUST00000126879.6 ENSMUST00000126879.7 F8VQL6 F8VQL6_MOUSE NM_178364 Zfp369 uc007qzj.1 uc007qzj.2 uc007qzj.3 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc007qzj.1 uc007qzj.2 uc007qzj.3 
ENSMUST00000126902.3 Rsf1os1 ENSMUST00000126902.3 Rsf1os1 (from geneSymbol) AK005667 ENSMUST00000126902.1 ENSMUST00000126902.2 uc009ijo.1 uc009ijo.2 uc009ijo.3 uc009ijo.1 uc009ijo.2 uc009ijo.3 
ENSMUST00000126906.8 Gm14552 ENSMUST00000126906.8 Gm14552 (from geneSymbol) AK139882 ENSMUST00000126906.1 ENSMUST00000126906.2 ENSMUST00000126906.3 ENSMUST00000126906.4 ENSMUST00000126906.5 ENSMUST00000126906.6 ENSMUST00000126906.7 uc009sxb.1 uc009sxb.2 uc009sxb.3 uc009sxb.1 uc009sxb.2 uc009sxb.3 
ENSMUST00000126922.3 2010013B24Rik ENSMUST00000126922.3 2010013B24Rik (from geneSymbol) AK008222 ENSMUST00000126922.1 ENSMUST00000126922.2 uc291ket.1 uc291ket.2 uc291ket.3 uc291ket.1 uc291ket.2 uc291ket.3 
ENSMUST00000126977.8 Svil ENSMUST00000126977.8 supervillin, transcript variant 1 (from RefSeq NM_153153.4) E9Q983 ENSMUST00000126977.1 ENSMUST00000126977.2 ENSMUST00000126977.3 ENSMUST00000126977.4 ENSMUST00000126977.5 ENSMUST00000126977.6 ENSMUST00000126977.7 NM_153153 Q8K4L3 SVIL_MOUSE uc008dyn.1 uc008dyn.2 uc008dyn.3 uc008dyn.4 [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). Associates with F-actin (By similarity). Interacts with NEB (By similarity). Interacts with MYH9 (By similarity). Interacts with MYLK (By similarity). Interacts with TASOR (PubMed:31112734). [Isoform 2]: Interacts with TRIP6 (By similarity). Interacts with DYNLT1 (By similarity). Interacts with KIF14; at midbody during cytokinesis (By similarity). Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Cell projection, invadopodium Cell projection, podosome Midbody Cleavage furrow Note=Tightly associated with both actin filaments and plasma membranes. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Archvillin ; IsoId=Q8K4L3-1; Sequence=Displayed; Name=2; Synonyms=Supervillin ; IsoId=Q8K4L3-3; Sequence=VSP_058333, VSP_058334; Expressed in the heart, tongue and granular cells within the cerebellum. As opposed to other villin-type headpiece domains, supervillin HP (SVHP) doesn't bind F-actin due to the absence of a conformationally flexible region (V-loop). Belongs to the villin/gelsolin family. podosome actin binding nucleus cytoplasm cytosol cytoskeleton plasma membrane cytoskeleton organization skeletal muscle tissue development actin cytoskeleton membrane cell junction midbody cleavage furrow positive regulation of cytokinesis microtubule minus-end cell projection costamere actin filament binding invadopodium uc008dyn.1 uc008dyn.2 uc008dyn.3 uc008dyn.4 
ENSMUST00000126980.8 Btbd2 ENSMUST00000126980.8 BTB domain containing 2, transcript variant 2 (from RefSeq NM_145361.3) Btbd2 E9PY28 E9PY28_MOUSE ENSMUST00000126980.1 ENSMUST00000126980.2 ENSMUST00000126980.3 ENSMUST00000126980.4 ENSMUST00000126980.5 ENSMUST00000126980.6 ENSMUST00000126980.7 NM_145361 uc287tbn.1 uc287tbn.2 P-body protein binding cytosol neurogenesis uc287tbn.1 uc287tbn.2 
ENSMUST00000126999.2 Gm12298 ENSMUST00000126999.2 predicted gene 12298 (from RefSeq NR_033539.1) ENSMUST00000126999.1 NR_033539 uc011xwk.1 uc011xwk.2 uc011xwk.3 uc011xwk.1 uc011xwk.2 uc011xwk.3 
ENSMUST00000127006.2 Gm11476 ENSMUST00000127006.2 Gm11476 (from geneSymbol) AK077405 ENSMUST00000127006.1 uc008nzz.1 uc008nzz.2 uc008nzz.1 uc008nzz.2 
ENSMUST00000127010.3 Gm12758 ENSMUST00000127010.3 predicted gene 12758 (from RefSeq NR_166613.1) ENSMUST00000127010.1 ENSMUST00000127010.2 NR_166613 uc009giy.1 uc009giy.2 uc009giy.3 uc009giy.1 uc009giy.2 uc009giy.3 
ENSMUST00000127012.10 ENSMUSG00000121861 ENSMUST00000127012.10 ENSMUSG00000121861 (from geneSymbol) AK015842 ENSMUST00000127012.1 ENSMUST00000127012.2 ENSMUST00000127012.3 ENSMUST00000127012.4 ENSMUST00000127012.5 ENSMUST00000127012.6 ENSMUST00000127012.7 ENSMUST00000127012.8 ENSMUST00000127012.9 uc292pvy.1 uc292pvy.2 uc292pvy.3 uc292pvy.1 uc292pvy.2 uc292pvy.3 
ENSMUST00000127017.2 Gm11192 ENSMUST00000127017.2 Gm11192 (from geneSymbol) ENSMUST00000127017.1 X81717 uc288ann.1 uc288ann.2 uc288ann.1 uc288ann.2 
ENSMUST00000127027.2 Zfp960 ENSMUST00000127027.2 zinc finger protein 960, transcript variant 2 (from RefSeq NM_001163919.1) ENSMUST00000127027.1 L7N267 L7N267_MOUSE NM_001163919 Zfp960 uc033hba.1 uc033hba.2 uc033hba.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc033hba.1 uc033hba.2 uc033hba.3 
ENSMUST00000127049.2 Gm14508 ENSMUST00000127049.2 Gm14508 (from geneSymbol) ENSMUST00000127049.1 KY468062 uc290ywh.1 uc290ywh.2 uc290ywh.1 uc290ywh.2 
ENSMUST00000127060.2 Gm12923 ENSMUST00000127060.2 Gm12923 (from geneSymbol) ENSMUST00000127060.1 uc290ppm.1 uc290ppm.2 uc290ppm.1 uc290ppm.2 
ENSMUST00000127098.2 ENSMUSG00000121442 ENSMUST00000127098.2 ENSMUSG00000121442 (from geneSymbol) ENSMUST00000127098.1 uc288abn.1 uc288abn.2 uc288abn.1 uc288abn.2 
ENSMUST00000127115.2 Gm15518 ENSMUST00000127115.2 Gm15518 (from geneSymbol) AK079748 ENSMUST00000127115.1 uc289eza.1 uc289eza.2 uc289eza.1 uc289eza.2 
ENSMUST00000127134.2 Rufy4 ENSMUST00000127134.2 RUN and FYVE domain containing 4, transcript variant 1 (from RefSeq NM_001170641.1) B2RX43 D3YY30 ENSMUST00000127134.1 NM_001170641 Q3TYX8 RUFY4_MOUSE uc011wmy.1 uc011wmy.2 uc011wmy.3 Positively regulates macroautophagy in primary dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE- type zinc finger. Interacts (via RUN domain) with RAB7A. Cytoplasmic vesicle, autophagosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TYX8-1; Sequence=Displayed; Name=2; IsoId=Q3TYX8-2; Sequence=VSP_035817; By IL4/interleukin-4 in dendritic cells. The RUN domain and the FYVE-type zinc finger are essential for its function in the positive regulation of macroautophagy. autophagosome assembly autophagosome autophagy positive regulation of macroautophagy cytoplasmic vesicle phosphatidylinositol-3-phosphate binding metal ion binding cellular response to interleukin-4 uc011wmy.1 uc011wmy.2 uc011wmy.3 
ENSMUST00000127150.9 Zeb2os ENSMUST00000127150.9 zinc finger E-box binding homeobox 2, opposite strand, transcript variant 1 (from RefSeq NR_110572.1) ENSMUST00000127150.1 ENSMUST00000127150.2 ENSMUST00000127150.3 ENSMUST00000127150.4 ENSMUST00000127150.5 ENSMUST00000127150.6 ENSMUST00000127150.7 ENSMUST00000127150.8 NR_110572 uc012bvd.1 uc012bvd.2 uc012bvd.3 uc012bvd.4 uc012bvd.5 uc012bvd.6 uc012bvd.1 uc012bvd.2 uc012bvd.3 uc012bvd.4 uc012bvd.5 uc012bvd.6 
ENSMUST00000127180.2 Gm11795 ENSMUST00000127180.2 Gm11795 (from geneSymbol) ENSMUST00000127180.1 uc290lbn.1 uc290lbn.2 uc290lbn.1 uc290lbn.2 
ENSMUST00000127188.3 Tmem240 ENSMUST00000127188.3 transmembrane protein 240 (from RefSeq NM_001101506.1) B2RWJ3 ENSMUST00000127188.1 ENSMUST00000127188.2 Gm5151 NM_001101506 TM240_MOUSE uc012dqw.1 uc012dqw.2 uc012dqw.3 Synapse Cell membrane ; Multi-pass membrane protein molecular_function plasma membrane biological_process membrane integral component of membrane cell junction synapse synaptic membrane uc012dqw.1 uc012dqw.2 uc012dqw.3 
ENSMUST00000127206.8 Rgs2 ENSMUST00000127206.8 regulator of G-protein signaling 2 (from RefSeq NM_009061.4) ENSMUST00000127206.1 ENSMUST00000127206.2 ENSMUST00000127206.3 ENSMUST00000127206.4 ENSMUST00000127206.5 ENSMUST00000127206.6 ENSMUST00000127206.7 NM_009061 O08849 Q544S7 Q91WX1 Q9JL24 RGS2_MOUSE uc007cxg.1 uc007cxg.2 uc007cxg.3 uc007cxg.4 Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (PubMed:14608379). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity). Interacts with GNAQ. Does not interact with GNAI1 and GNAI3. Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha). Cell membrane Cytoplasm Nucleus, nucleolus Expressed in a wide variety of tissues. Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity. Mutant mice display increased blood pressure and impaired relaxation of vascular smooth muscle. G-protein alpha-subunit binding response to amphetamine GTPase activator activity protein binding nucleus nucleolus cytoplasm cytosol plasma membrane regulation of translation cell cycle G-protein coupled receptor signaling pathway spermatogenesis brain development regulation of G-protein coupled receptor protein signaling pathway cytoplasmic side of plasma membrane negative regulation of signal transduction negative regulation of phospholipase activity negative regulation of cardiac muscle hypertrophy positive regulation of neuron projection development membrane negative regulation of translation ovulation neuron projection negative regulation of MAP kinase activity positive regulation of GTPase activity negative regulation of cAMP-mediated signaling response to ethanol negative regulation of G-protein coupled receptor protein signaling pathway beta-tubulin binding brown fat cell differentiation relaxation of cardiac muscle relaxation of vascular smooth muscle maternal process involved in female pregnancy positive regulation of cardiac muscle contraction negative regulation of cell growth involved in cardiac muscle cell development negative regulation of glycine import uc007cxg.1 uc007cxg.2 uc007cxg.3 uc007cxg.4 
ENSMUST00000127208.8 Lrrc14 ENSMUST00000127208.8 Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB. (from UniProt Q8VC16) AK053747 ENSMUST00000127208.1 ENSMUST00000127208.2 ENSMUST00000127208.3 ENSMUST00000127208.4 ENSMUST00000127208.5 ENSMUST00000127208.6 ENSMUST00000127208.7 Kiaa0014 LRC14_MOUSE Lrrc14 Q6A0E7 Q80WK3 Q8VC16 uc007wma.1 uc007wma.2 uc007wma.3 Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB. Interacts with IKBKB; disrupts IKBKB-IKBKG interaction preventing I-kappa-B-kinase (IKK) core complex formation and leading to a decrease of IKBKB phosphorylation and NF-kappaB activation. Interacts with CHUK. Cytoplasm Belongs to the PRAME family. LRRC14 subfamily. Sequence=BAD32149.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; cytoplasm kinase binding negative regulation of NF-kappaB transcription factor activity negative regulation of toll-like receptor signaling pathway uc007wma.1 uc007wma.2 uc007wma.3 
ENSMUST00000127230.2 Gm14155 ENSMUST00000127230.2 Gm14155 (from geneSymbol) AK042249 ENSMUST00000127230.1 uc008neo.1 uc008neo.2 uc008neo.3 uc008neo.1 uc008neo.2 uc008neo.3 
ENSMUST00000127247.4 Tmem229a ENSMUST00000127247.4 transmembrane protein 229A (from RefSeq NM_177013.3) B9EJI9 ENSMUST00000127247.1 ENSMUST00000127247.2 ENSMUST00000127247.3 NM_177013 T229A_MOUSE uc009bcc.1 uc009bcc.2 uc009bcc.3 Membrane ; Multi-pass membrane protein Belongs to the TMEM229 family. molecular_function cellular_component biological_process membrane integral component of membrane uc009bcc.1 uc009bcc.2 uc009bcc.3 
ENSMUST00000127301.9 9430091E24Rik ENSMUST00000127301.9 RIKEN cDNA 9430091E24 gene, transcript variant 2 (from RefSeq NR_040364.1) ENSMUST00000127301.1 ENSMUST00000127301.2 ENSMUST00000127301.3 ENSMUST00000127301.4 ENSMUST00000127301.5 ENSMUST00000127301.6 ENSMUST00000127301.7 ENSMUST00000127301.8 NR_040364 uc009nly.1 uc009nly.2 uc009nly.3 uc009nly.4 uc009nly.5 uc009nly.1 uc009nly.2 uc009nly.3 uc009nly.4 uc009nly.5 
ENSMUST00000127305.2 Epn3 ENSMUST00000127305.2 epsin 3, transcript variant 1 (from RefSeq NM_027984.3) ENSMUST00000127305.1 EPN3_MOUSE NM_027984 Q91W69 Q9CV55 uc007kyu.1 uc007kyu.2 uc007kyu.3 Cytoplasm, cell cortex Cytoplasm, perinuclear region Cytoplasmic vesicle, clathrin-coated vesicle Note=Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the cell periphery. May shuttle to the nucleus (By similarity). In keratinocytes, by wounding or contact with collagen. Belongs to the epsin family. nucleus nucleoplasm cytoplasm clathrin-coated pit cell cortex biological_process lipid binding extrinsic component of plasma membrane clathrin-coated vesicle cytoplasmic vesicle intracellular membrane-bounded organelle perinuclear region of cytoplasm EH domain binding uc007kyu.1 uc007kyu.2 uc007kyu.3 
ENSMUST00000127306.2 Enho ENSMUST00000127306.2 energy homeostasis associated (from RefSeq NM_027147.1) ENHO_MOUSE ENSMUST00000127306.1 NM_027147 Q8K1D8 uc008sjd.1 uc008sjd.2 uc008sjd.3 uc008sjd.4 Involved in the regulation of glucose homeostasis and lipid metabolism. Secreted Expressed in liver and brain. Expressed in regions of the brain involved in metabolic regulation. In liver, up-regulated in mice fed a high-fat diet for 2 days, and down-regulated in obese mice fed a chronic high fat diet. Also down-regulated in liver 4 hours after treatment with LXR agonist GW3965. hormone activity protein binding extracellular region plasma membrane signal transduction positive regulation of Notch signaling pathway negative regulation of insulin receptor signaling pathway negative regulation of insulin secretion negative regulation of lipid biosynthetic process negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding uc008sjd.1 uc008sjd.2 uc008sjd.3 uc008sjd.4 
ENSMUST00000127307.2 Gm15891 ENSMUST00000127307.2 Gm15891 (from geneSymbol) ENSMUST00000127307.1 uc292jwl.1 uc292jwl.2 uc292jwl.1 uc292jwl.2 
ENSMUST00000127317.2 Gm15999 ENSMUST00000127317.2 Gm15999 (from geneSymbol) AK080237 ENSMUST00000127317.1 uc290hxu.1 uc290hxu.2 uc290hxu.1 uc290hxu.2 
ENSMUST00000127348.8 Gatb ENSMUST00000127348.8 glutamyl-tRNA amidotransferase subunit B, transcript variant 1 (from RefSeq NM_144896.5) ENSMUST00000127348.1 ENSMUST00000127348.2 ENSMUST00000127348.3 ENSMUST00000127348.4 ENSMUST00000127348.5 ENSMUST00000127348.6 ENSMUST00000127348.7 GATB_MOUSE Gatb NM_144896 Pet112 Pet112l Q8BMU3 Q8BUY3 Q99JT1 uc008pqs.1 uc008pqs.2 uc008pqs.3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate; Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216; Evidence=; Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. Mitochondrion Belongs to the GatB/GatE family. GatB subfamily. nucleotide binding catalytic activity ATP binding mitochondrion translation ligase activity carbon-nitrogen ligase activity, with glutamine as amido-N-donor glutamyl-tRNA(Gln) amidotransferase complex mitochondrial translation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity glutaminyl-tRNAGln biosynthesis via transamidation uc008pqs.1 uc008pqs.2 uc008pqs.3 
ENSMUST00000127404.8 Tmsb15l ENSMUST00000127404.8 thymosin beta 15b like (from RefSeq NM_207267.4) 4930488E11Rik ENSMUST00000127404.1 ENSMUST00000127404.2 ENSMUST00000127404.3 ENSMUST00000127404.4 ENSMUST00000127404.5 ENSMUST00000127404.6 ENSMUST00000127404.7 NM_207267 Q8C0W0 Q8C0W0_MOUSE Tmsb15l uc009ujh.1 uc009ujh.2 uc009ujh.3 uc009ujh.4 This record represents readthrough transcripts derived from two adjacent genes, represented by GeneIDs 100034363 and 666244. Each gene has three exons. The readthrough transcripts include two exons from each gene, such that the second exon is represented twice, although not identically, in the readthrough transcripts. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 666244, 100034363 ##RefSeq-Attributes-END## Belongs to the thymosin beta family. stress fiber actin monomer binding cytoplasm actin filament organization regulation of cell migration negative regulation of actin filament polymerization filamentous actin sequestering of actin monomers negative regulation of stress fiber assembly uc009ujh.1 uc009ujh.2 uc009ujh.3 uc009ujh.4 
ENSMUST00000127405.2 Nhp2 ENSMUST00000127405.2 NHP2 ribonucleoprotein, transcript variant 2 (from RefSeq NR_157294.1) ENSMUST00000127405.1 NHP2_MOUSE NR_157294 Nola2 Q9CRB2 uc007iuc.1 uc007iuc.2 uc007iuc.3 Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable core formed by binding of one or two NOP10- DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate. During assembly, the complex contains NAF1 instead of GAR1/NOLA1. The complex also interacts with TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs. Specific interactions with snoRNAs or TERC are mediated by GAR1 and NHP2. Associates with NOLC1/NOPP140. H/ACA snoRNPs interact with the SMN complex, consisting of SMN1 or SMN2, GEMIN2/SIP1, DDX20/GEMIN3, and GEMIN4. This is mediated by interaction between GAR1 and SMN1 or SMN2. The SMN complex may be required for correct assembly of the H/ACA snoRNP complex. Component of the telomerase holoenzyme complex composed of one molecule of TERT, one molecule of WRAP53/TCAB1, two molecules of H/ACA ribonucleoprotein complex subunits DKC1, NOP10, NHP2 and GAR1, and a telomerase RNA template component (TERC). The telomerase holoenzyme complex is associated with TEP1, SMG6/EST1A and POT1. Nucleus, nucleolus Nucleus, Cajal body Note=Also localized to Cajal bodies (coiled bodies). Belongs to the eukaryotic ribosomal protein eL8 family. cleavage involved in rRNA processing maturation of LSU-rRNA RNA binding protein binding nucleus telomerase holoenzyme complex nucleolus small nucleolar ribonucleoprotein complex rRNA processing telomere maintenance via telomerase Cajal body rRNA pseudouridine synthesis snRNA pseudouridine synthesis box H/ACA snoRNP complex box H/ACA snoRNA binding ribosome biogenesis telomerase RNA binding box H/ACA telomerase RNP complex uc007iuc.1 uc007iuc.2 uc007iuc.3 
ENSMUST00000127408.3 Gm41142 ENSMUST00000127408.3 predicted gene, 16976 (from RefSeq NR_167765.1) ENSMUST00000127408.1 ENSMUST00000127408.2 NR_167765 uc007tes.1 uc007tes.2 uc007tes.3 uc007tes.4 uc007tes.1 uc007tes.2 uc007tes.3 uc007tes.4 
ENSMUST00000127424.8 Gm12339 ENSMUST00000127424.8 Gm12339 (from geneSymbol) ENSMUST00000127424.1 ENSMUST00000127424.2 ENSMUST00000127424.3 ENSMUST00000127424.4 ENSMUST00000127424.5 ENSMUST00000127424.6 ENSMUST00000127424.7 uc288agp.1 uc288agp.2 uc288agp.1 uc288agp.2 
ENSMUST00000127430.2 Smchd1 ENSMUST00000127430.2 SMC hinge domain containing 1 (from RefSeq NM_028887.4) ENSMUST00000127430.1 Kiaa0650 NM_028887 Q6P5D8 Q6PDM8 Q6PE93 Q6ZQ78 Q811H3 Q8BP09 Q9D4M7 SMHD1_MOUSE Smchd1 uc008dmh.1 uc008dmh.2 uc008dmh.3 uc008dmh.4 Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (PubMed:26091879, PubMed:29887375). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (PubMed:23754746, PubMed:23819640, PubMed:26391951, PubMed:28587678, PubMed:29887375). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:18425126, PubMed:22841499, PubMed:26391951, PubMed:29887375). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (PubMed:29887375). Required to facilitate Xist RNA spreading (PubMed:29887375). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23754746, PubMed:23819640, PubMed:28587678). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:26391951, PubMed:27059856). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (By similarity). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (By similarity). Required during preimplantation development, probably acts by regulating chromatin architecture (PubMed:29900695). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Homodimer; homodimerizes via its SMC hinge domain (PubMed:26391951, PubMed:26733688, PubMed:27059856). Interacts with LRIF1 (PubMed:26391951). Chromosome Note=Recruited to inactivated chromosome X in females by Xist RNA (PubMed:29887375). Localizes at sites of DNA damage at double-strand breaks (DSBs) (By similarity). During embryogenesis, specifically expressed in immature olfactory sensory neurons. Expressed in the nasal placodes and optic vesicles at day 9.5 dpc and in the nasal epithelium at 12.5 dpc (PubMed:28067911). Expressed in the nasal cavity in 14.5 dpc animals (PubMed:28067911). Expression is repressed by CDX2. Atypical member of the structural maintenance of chromosomes (SMC) protein family (PubMed:26733688, PubMed:27059856). Like other members of the SMC family, has ATPase activity, which is probably necessary for its engagement with chromatin, and a SMC hinge domain (PubMed:26733688, PubMed:27059856). However, the SMC hinge domain adopts an unconventional homodimeric arrangement augmented by an intermolecular coiled coil formed between the two monomers. This suggests that protein may assemble as a head-to-head parallel dimer without adopting a hairpin shape at the hinge domain, unlike the dimeric arrangement conventionally found in other members of the SMC protein family (PubMed:26733688). The SMC hinge domain binds DNA and RNA (PubMed:26091879). Sumoylated with SUMO1. Defects in Smchd1 are the cause of the MommeD1 (modifier of murine metastable epialleles) phenotype, a semi-dominant suppressor of variegation (PubMed:18425126, PubMed:21553025). Mice display female-specific mid-gestation lethality and hypomethylation of the X-linked gene Hprt1, due to defects in X inactivation (PubMed:18425126, PubMed:21553025, PubMed:23754746). Mice do not show defects on telomeres length (PubMed:18425126, PubMed:21553025). Male mice are less affected, with some surviving to become fertile adults on the FVB/n genetic background (PubMed:18425126). On other genetic backgrounds, all males lacking die perinatally (PubMed:18425126). A subset of clustered autosomal loci display hypomethylation and derepression (PubMed:23754746, PubMed:23819640, PubMed:28587678). Belongs to the SMC family. Highly divergent. Sequence=AAH44905.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB30222.1; Type=Frameshift; Evidence=; nuclear chromosome, telomeric region Barr body DNA binding protein binding ATP binding chromosome DNA repair double-strand break repair chromatin organization cellular response to DNA damage stimulus dosage compensation by inactivation of X chromosome hydrolase activity ATPase activity site of double-strand break protein homodimerization activity nose development positive regulation of DNA repair chromosome organization inactivation of X chromosome by heterochromatin assembly inactivation of X chromosome by DNA methylation heterochromatin organization involved in chromatin silencing negative regulation of double-strand break repair via homologous recombination positive regulation of double-strand break repair via nonhomologous end joining uc008dmh.1 uc008dmh.2 uc008dmh.3 uc008dmh.4 
ENSMUST00000127450.4 Rptoros ENSMUST00000127450.4 regulatory associated protein of MTOR, complex 1, opposite strand, transcript variant 2 (from RefSeq NR_045313.1) ENSMUST00000127450.1 ENSMUST00000127450.2 ENSMUST00000127450.3 NR_045313 uc029rqc.1 uc029rqc.2 uc029rqc.3 uc029rqc.4 uc029rqc.5 uc029rqc.1 uc029rqc.2 uc029rqc.3 uc029rqc.4 uc029rqc.5 
ENSMUST00000127456.2 Gm12580 ENSMUST00000127456.2 Gm12580 (from geneSymbol) AK078800 ENSMUST00000127456.1 uc290myd.1 uc290myd.2 uc290myd.1 uc290myd.2 
ENSMUST00000127465.3 Vmn1r239-ps ENSMUST00000127465.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A494BAP1) A0A494BAP1 A0A494BAP1_MOUSE BC146392 ENSMUST00000127465.1 ENSMUST00000127465.2 Vmn1r239-ps uc292qzr.1 uc292qzr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc292qzr.1 uc292qzr.2 
ENSMUST00000127477.8 Ndufb5 ENSMUST00000127477.8 NADH:ubiquinone oxidoreductase subunit B5 (from RefSeq NM_025316.2) ENSMUST00000127477.1 ENSMUST00000127477.2 ENSMUST00000127477.3 ENSMUST00000127477.4 ENSMUST00000127477.5 ENSMUST00000127477.6 ENSMUST00000127477.7 NDUB5_MOUSE NM_025316 Q9CQH3 uc008owq.1 uc008owq.2 uc008owq.3 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side Belongs to the complex I NDUFB5 subunit family. molecular_function nucleoplasm mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I membrane integral component of membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc008owq.1 uc008owq.2 uc008owq.3 
ENSMUST00000127483.2 Gm12050 ENSMUST00000127483.2 Gm12050 (from geneSymbol) AK139672 ENSMUST00000127483.1 uc287wxm.1 uc287wxm.2 uc287wxm.1 uc287wxm.2 
ENSMUST00000127498.3 Pard3bos2 ENSMUST00000127498.3 par-3 family cell polarity regulator beta, opposite strand 2 (from RefSeq NR_151537.1) ENSMUST00000127498.1 ENSMUST00000127498.2 NR_151537 uc287iqn.1 uc287iqn.2 uc287iqn.1 uc287iqn.2 
ENSMUST00000127510.9 Gm11978 ENSMUST00000127510.9 predicted gene 11978 (from RefSeq NR_028586.2) ENSMUST00000127510.1 ENSMUST00000127510.2 ENSMUST00000127510.3 ENSMUST00000127510.4 ENSMUST00000127510.5 ENSMUST00000127510.6 ENSMUST00000127510.7 ENSMUST00000127510.8 NR_028586 uc007hzc.1 uc007hzc.2 uc007hzc.3 uc007hzc.1 uc007hzc.2 uc007hzc.3 
ENSMUST00000127525.2 9830144P21Rik ENSMUST00000127525.2 9830144P21Rik (from geneSymbol) AK036644 ENSMUST00000127525.1 uc290ajt.1 uc290ajt.2 uc290ajt.1 uc290ajt.2 
ENSMUST00000127527.2 Gm16183 ENSMUST00000127527.2 Gm16183 (from geneSymbol) ENSMUST00000127527.1 uc292bnt.1 uc292bnt.2 uc292bnt.1 uc292bnt.2 
ENSMUST00000127537.6 Gm28053 ENSMUST00000127537.6 Gm28053 (from geneSymbol) AB126961 D3YZL2 D3YZL2_MOUSE ENSMUST00000127537.1 ENSMUST00000127537.2 ENSMUST00000127537.3 ENSMUST00000127537.4 ENSMUST00000127537.5 Gimap1 Gm28053 uc291egl.1 uc291egl.2 uc291egl.1 uc291egl.2 
ENSMUST00000127559.2 Slc2a4rg-ps ENSMUST00000127559.2 Slc2a4 regulator, pseudogene (from RefSeq NR_045164.1) ENSMUST00000127559.1 NR_045164 uc008omf.1 uc008omf.2 uc008omf.3 uc008omf.4 uc008omf.1 uc008omf.2 uc008omf.3 uc008omf.4 
ENSMUST00000127564.3 Gm15910 ENSMUST00000127564.3 predicted gene 15910 (from RefSeq NR_038023.1) ENSMUST00000127564.1 ENSMUST00000127564.2 NR_038023 uc029rjk.1 uc029rjk.2 uc029rjk.3 uc029rjk.4 uc029rjk.1 uc029rjk.2 uc029rjk.3 uc029rjk.4 
ENSMUST00000127569.8 Usp3 ENSMUST00000127569.8 ubiquitin specific peptidase 3, transcript variant 1 (from RefSeq NM_144937.4) ENSMUST00000127569.1 ENSMUST00000127569.2 ENSMUST00000127569.3 ENSMUST00000127569.4 ENSMUST00000127569.5 ENSMUST00000127569.6 ENSMUST00000127569.7 NM_144937 Q91W36 UBP3_MOUSE uc009qey.1 uc009qey.2 uc009qey.3 uc009qey.4 The protein encoded by this gene is a chromatin-associated histone 2A and 2B deubiquitinating enzyme that negatively regulates the DNA damage response. Mice deficient for this enzyme have reduced hematopoietic stem cell reserves, demonstrating a requirement in hematopoietic stem cell homeostasis. In addition, knock down of protein levels results in spontaneous tumor development and shortened lifespan, consistent with a function in preserving chromosomal integrity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Interacts (via UBP-type domain) with H2A; the interaction is less efficient than with monoubiquitinated H2A. Nucleus. Note=Localizes preferentially with monoubiquitinated H2A to chromatin. Both protease activity and an intact zinc finger are required for H2A monodeubiquitination. Belongs to the peptidase C19 family. USP3 subfamily. negative regulation of transcription from RNA polymerase II promoter mitotic cell cycle nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding thiol-dependent ubiquitin-specific protease activity nucleus nucleoplasm DNA repair chromatin organization proteolysis ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus cell cycle peptidase activity cysteine-type peptidase activity zinc ion binding histone deubiquitination protein deubiquitination hydrolase activity regulation of protein stability thiol-dependent ubiquitinyl hydrolase activity cytoplasmic ribonucleoprotein granule histone binding metal ion binding Flemming body promoter-specific chromatin binding uc009qey.1 uc009qey.2 uc009qey.3 uc009qey.4 
ENSMUST00000127576.3 Gm15343 ENSMUST00000127576.3 RIKEN cDNA 4930483K19 gene (from RefSeq NR_045354.1) ENSMUST00000127576.1 ENSMUST00000127576.2 NR_045354 uc029qzm.1 uc029qzm.2 uc029qzm.1 uc029qzm.2 
ENSMUST00000127587.8 Tlcd1 ENSMUST00000127587.8 TLC domain containing 1, transcript variant 1 (from RefSeq NM_026708.2) ENSMUST00000127587.1 ENSMUST00000127587.2 ENSMUST00000127587.3 ENSMUST00000127587.4 ENSMUST00000127587.5 ENSMUST00000127587.6 ENSMUST00000127587.7 NM_026708 Q3V372 Q5SYM9 Q8CHT9 Q99JT6 Q9DCK5 TLCD1_MOUSE uc007kij.1 uc007kij.2 uc007kij.3 uc007kij.4 uc007kij.5 Regulates the composition and fluidity of the plasma membrane (By similarity). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (By similarity). Does not appear to have any effect on LCPUFA synthesis (By similarity). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q99JT6-1; Sequence=Displayed; Name=2; IsoId=Q99JT6-2; Sequence=VSP_024890; Name=3; IsoId=Q99JT6-3; Sequence=VSP_024887; Name=4; IsoId=Q99JT6-4; Sequence=VSP_024888, VSP_024889; Was originally proposed to be a calcium channel facilitator (By similarity). However, a more recent study shows that this protein regulates membrane phospholipid homeostasis (By similarity). Therefore, any effects on calcium flux are most likely a secondary consequence of defects in membrane composition or fluidity (By similarity). molecular_function plasma membrane plasma membrane organization membrane integral component of membrane phospholipid homeostasis membrane assembly regulation of membrane lipid distribution uc007kij.1 uc007kij.2 uc007kij.3 uc007kij.4 uc007kij.5 
ENSMUST00000127604.2 Gm12146 ENSMUST00000127604.2 Gm12146 (from geneSymbol) ENSMUST00000127604.1 uc287xms.1 uc287xms.2 uc287xms.1 uc287xms.2 
ENSMUST00000127620.3 Gm16150 ENSMUST00000127620.3 Gm16150 (from geneSymbol) ENSMUST00000127620.1 ENSMUST00000127620.2 uc287hmx.1 uc287hmx.2 uc287hmx.3 uc287hmx.1 uc287hmx.2 uc287hmx.3 
ENSMUST00000127631.2 Gm15991 ENSMUST00000127631.2 Gm15991 (from geneSymbol) ENSMUST00000127631.1 uc292aik.1 uc292aik.2 uc292aik.1 uc292aik.2 
ENSMUST00000127642.8 Fcnaos ENSMUST00000127642.8 Fcnaos (from geneSymbol) AK039020 ENSMUST00000127642.1 ENSMUST00000127642.2 ENSMUST00000127642.3 ENSMUST00000127642.4 ENSMUST00000127642.5 ENSMUST00000127642.6 ENSMUST00000127642.7 uc008isw.1 uc008isw.2 uc008isw.1 uc008isw.2 
ENSMUST00000127648.4 Apoc2l ENSMUST00000127648.4 Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. (from UniProt Q3UJG0) Apoc2 BC024697 D3YXE8 ENSMUST00000127648.1 ENSMUST00000127648.2 ENSMUST00000127648.3 Q3UJG0 Q3UJG0_MOUSE uc291mlt.1 uc291mlt.2 Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Secreted Belongs to the apolipoprotein C2 family. lipid metabolic process lipid transport enzyme activator activity chylomicron positive regulation of catalytic activity uc291mlt.1 uc291mlt.2 
ENSMUST00000127672.2 Gm13481 ENSMUST00000127672.2 predicted gene 13481 (from RefSeq NR_166463.1) ENSMUST00000127672.1 NR_166463 uc289vzb.1 uc289vzb.2 uc289vzb.1 uc289vzb.2 
ENSMUST00000127673.2 9530051G07Rik ENSMUST00000127673.2 RIKEN cDNA 9530051G07 gene (from RefSeq NR_040272.1) ENSMUST00000127673.1 NR_040272 uc009uqr.1 uc009uqr.2 uc009uqr.1 uc009uqr.2 
ENSMUST00000127678.4 Gm12655 ENSMUST00000127678.4 predicted gene 12655, transcript variant 2 (from RefSeq NR_176041.1) ENSMUST00000127678.1 ENSMUST00000127678.2 ENSMUST00000127678.3 NR_176041 uc290nui.1 uc290nui.2 uc290nui.3 uc290nui.4 uc290nui.1 uc290nui.2 uc290nui.3 uc290nui.4 
ENSMUST00000127688.3 Gm14110 ENSMUST00000127688.3 Gm14110 (from geneSymbol) ENSMUST00000127688.1 ENSMUST00000127688.2 uc290bdh.1 uc290bdh.2 uc290bdh.3 uc290bdh.1 uc290bdh.2 uc290bdh.3 
ENSMUST00000127698.8 Tbpl1 ENSMUST00000127698.8 TATA box binding protein-like 1, transcript variant 1 (from RefSeq NM_011603.6) ENSMUST00000127698.1 ENSMUST00000127698.2 ENSMUST00000127698.3 ENSMUST00000127698.4 ENSMUST00000127698.5 ENSMUST00000127698.6 ENSMUST00000127698.7 NM_011603 O95753 P62340 Q9Z2Z0 TBPL1_MOUSE Tlf Tlp Tlp21 Trf2 Trp uc007epp.1 uc007epp.2 uc007epp.3 uc007epp.4 Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes (By similarity). Seems to also mediate the transcription of NF1. Does not bind the TATA box. Binds TFIIA and TFIIB. Cytoplasm Nucleus Ubiquitously expressed. Significantly reduced NF1 levels. Belongs to the TBP family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding acrosome assembly DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex transcription factor TFIIA complex cytoplasm dTTP biosynthetic process DNA-templated transcription, initiation transcription from RNA polymerase II promoter spermatogenesis spermatid nucleus differentiation transcription factor binding positive regulation of transcription from RNA polymerase II promoter uc007epp.1 uc007epp.2 uc007epp.3 uc007epp.4 
ENSMUST00000127709.2 Gm12478 ENSMUST00000127709.2 Gm12478 (from geneSymbol) ENSMUST00000127709.1 uc290mum.1 uc290mum.2 uc290mum.1 uc290mum.2 
ENSMUST00000127711.2 Gm16224 ENSMUST00000127711.2 Gm16224 (from geneSymbol) ENSMUST00000127711.1 uc290qut.1 uc290qut.2 uc290qut.1 uc290qut.2 
ENSMUST00000127730.2 Ifi207 ENSMUST00000127730.2 Belongs to the HIN-200 family. (from UniProt D3Z2E7) AI607873 BC150711 D3Z2E7 D3Z2E7_MOUSE ENSMUST00000127730.1 Ifi207 uc287oba.1 uc287oba.2 Belongs to the HIN-200 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding activation of innate immune response double-stranded DNA binding nucleus nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding uc287oba.1 uc287oba.2 
ENSMUST00000127748.5 Tril ENSMUST00000127748.5 TLR4 interactor with leucine-rich repeats (from RefSeq NM_025817.4) ENSMUST00000127748.1 ENSMUST00000127748.2 ENSMUST00000127748.3 ENSMUST00000127748.4 Kiaa0644 NM_025817 Q80TV0 Q8BKM5 Q9DBY4 TRIL_MOUSE uc009bzk.1 uc009bzk.2 uc009bzk.3 uc009bzk.4 Component of the TLR4 signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion (By similarity). Belongs to the lipopolysaccharide (LPS) receptor, a multi- protein complex containing at least CD14, MD-2 and TLR4. Interacts with TLR4; this interaction is greatly enhanced by LPS stimulation (By similarity). Interacts with LPS (By similarity). Membrane ; Single-pass type I membrane protein Highly expressed in brain, spinal cord and lung. By bacterial lipopolysaccharides (LPS) (in vivo and in vitro). N-glycolysaled. Sequence=BAC65620.1; Type=Frameshift; Evidence=; lipopolysaccharide binding immune system process regulation of cytokine production involved in immune response extracellular space inflammatory response membrane integral component of membrane extracellular matrix toll-like receptor 4 signaling pathway innate immune response lipopolysaccharide receptor complex uc009bzk.1 uc009bzk.2 uc009bzk.3 uc009bzk.4 
ENSMUST00000127752.2 Gm13096 ENSMUST00000127752.2 Gm13096 (from geneSymbol) ENSMUST00000127752.1 uc290sea.1 uc290sea.2 uc290sea.1 uc290sea.2 
ENSMUST00000127756.8 Adcy3 ENSMUST00000127756.8 adenylate cyclase 3, transcript variant 1 (from RefSeq NM_138305.4) ADCY3_MOUSE B8JK57 ENSMUST00000127756.1 ENSMUST00000127756.2 ENSMUST00000127756.3 ENSMUST00000127756.4 ENSMUST00000127756.5 ENSMUST00000127756.6 ENSMUST00000127756.7 NM_138305 Q8VHH7 uc288epx.1 uc288epx.2 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:9768837, PubMed:11055432, PubMed:25329148). Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis (PubMed:9768837, PubMed:11055432). Required for the perception of odorants (PubMed:11055432). Required for normal sperm motility and normal male fertility (PubMed:15705663). Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet (PubMed:25329148). Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro). ; Activated by forskolin (PubMed:11055432, PubMed:25329148). After forskolin treatment, activity is further increased by calcium/calmodulin. In the absence of forskolin, calcium/calmodulin has little effect on enzyme activity (By similarity). Cell membrane ; Multi-pass membrane protein Cell projection, cilium Golgi apparatus Cytoplasm Detected in the acrosomal region of epididymal spermatozoa, the acrosomal region of round spermatids and in elongating spermatids (PubMed:15705663). Detected in cilia in the olfactory epithelium (at protein level) (PubMed:9768837, PubMed:11055432, PubMed:25908845). Detected in olfactory epithelium neurons (PubMed:11055432). Detected in brain, testis, late pachytene spermatocytes, round spermatids and elongating spermatids (PubMed:15705663). The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules. N-glycosylated. Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1077 down-regulates enzyme activity. Sumoylated (PubMed:25908845). Sumoylation is required for targeting of olfactory cilia. Mutant mice are born at the expected Mendelian rate, but up to 80% of the pups die within 48 hours after birth. Survival is improved by paring down the litter size shortly after birth. Mutant mice are initially smaller than wild-type, but achieve normal size within three months. Mutant mice do not display the normal electrophysiological responses to odorants that stimulate production of cAMP or inositoltrisphosphate (IP3). Likewise, behavorial responses to smells are abolished (PubMed:11055432). In spite of normal mating behavior, they do not produce any offspring (PubMed:11055432, PubMed:15705663). Male mice have strongly reduced fertility due to defects in sperm motility, an increased rate of spontaneous acrosome reactions and an impaired ability to penetrate the oocyte zona (PubMed:15705663). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding adenylate cyclase activity protein binding calmodulin binding ATP binding nucleus cytoplasm Golgi apparatus plasma membrane integral component of plasma membrane cilium cAMP biosynthetic process adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity single fertilization acrosome reaction sensory perception of smell calcium- and calmodulin-responsive adenylate cyclase activity olfactory learning cyclic nucleotide biosynthetic process membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity flagellated sperm motility intracellular signal transduction cell projection membrane raft metal ion binding response to stimulus cellular response to forskolin uc288epx.1 uc288epx.2 
ENSMUST00000127757.8 Gm11033 ENSMUST00000127757.8 Gm11033 (from geneSymbol) AK166041 ENSMUST00000127757.1 ENSMUST00000127757.2 ENSMUST00000127757.3 ENSMUST00000127757.4 ENSMUST00000127757.5 ENSMUST00000127757.6 ENSMUST00000127757.7 uc009mgu.1 uc009mgu.2 uc009mgu.1 uc009mgu.2 
ENSMUST00000127764.2 Gm12238 ENSMUST00000127764.2 Gm12238 (from geneSymbol) AF357392 ENSMUST00000127764.1 uc011xvb.1 uc011xvb.2 uc011xvb.1 uc011xvb.2 
ENSMUST00000127786.4 Xist ENSMUST00000127786.4 inactive X specific transcripts, transcript variant 2 (from RefSeq NR_001570.2) ENSMUST00000127786.1 ENSMUST00000127786.2 ENSMUST00000127786.3 NR_001570 uc009tzp.1 uc009tzp.2 uc009tzp.3 X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome. It is essential for the initiation and spread of X-inactivation. It silences hundreds of genes by recruiting and tethering repressive chromatin-modifying complexes to the inactive X chromosome. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]. uc009tzp.1 uc009tzp.2 uc009tzp.3 
ENSMUST00000127789.3 Or1e21 ENSMUST00000127789.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGT3) B0QZP1 ENSMUST00000127789.1 ENSMUST00000127789.2 Olfr376 Olfr380 Or1e21 Q8VGT3 Q8VGT3_MOUSE uc287zzl.1 uc287zzl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287zzl.1 uc287zzl.2 
ENSMUST00000127849.2 Gm13630 ENSMUST00000127849.2 Gm13630 (from geneSymbol) AK034270 ENSMUST00000127849.1 uc289wnv.1 uc289wnv.2 uc289wnv.1 uc289wnv.2 
ENSMUST00000127875.2 Gm13055 ENSMUST00000127875.2 Gm13055 (from geneSymbol) AK037041 ENSMUST00000127875.1 uc290riq.1 uc290riq.2 uc290riq.1 uc290riq.2 
ENSMUST00000127883.2 Gm12347 ENSMUST00000127883.2 Gm12347 (from geneSymbol) ENSMUST00000127883.1 uc288ccp.1 uc288ccp.2 uc288ccp.1 uc288ccp.2 
ENSMUST00000127984.9 Cbfa2t3 ENSMUST00000127984.9 CBFA2/RUNX1 translocation partner 3, transcript variant 1 (from RefSeq NM_009824.2) B7ZP57 B7ZP57_MOUSE Cbfa2t3 ENSMUST00000127984.1 ENSMUST00000127984.2 ENSMUST00000127984.3 ENSMUST00000127984.4 ENSMUST00000127984.5 ENSMUST00000127984.6 ENSMUST00000127984.7 ENSMUST00000127984.8 NM_009824 uc009ntn.1 uc009ntn.2 uc009ntn.3 uc009ntn.4 Belongs to the CBFA2T family. response to hypoxia transcription factor activity, sequence-specific DNA binding transcription corepressor activity nucleoplasm regulation of transcription, DNA-templated negative regulation of cell proliferation granulocyte differentiation positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of glycolytic process negative regulation of transcription, DNA-templated metal ion binding regulation of aerobic respiration uc009ntn.1 uc009ntn.2 uc009ntn.3 uc009ntn.4 
ENSMUST00000127988.8 Arfrp1 ENSMUST00000127988.8 ADP-ribosylation factor related protein 1, transcript variant 2 (from RefSeq NM_029702.4) ARFRP_MOUSE ENSMUST00000127988.1 ENSMUST00000127988.2 ENSMUST00000127988.3 ENSMUST00000127988.4 ENSMUST00000127988.5 ENSMUST00000127988.6 ENSMUST00000127988.7 NM_029702 Q8BXL7 uc008olz.1 uc008olz.2 uc008olz.3 uc008olz.4 The gene encodes a membrane-associated GTPase that is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. It plays an essential role in Golgi function controlling recruitment of GRIP domain proteins and ARL1 to the trans-Golgi and trans-Golgi to plasma membrane trafficking of cell surface proteins such as E-cadherin. Deletion of this gene in mice leads to embryonic lethality during early gastrulation, which is at least partly caused by the disruption of E-cadherin trafficking to the cell surface and therefore lack of sufficient cell-cell adhesion in the embryo. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]. Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Interacts with SYS1. Golgi apparatus Golgi apparatus, trans-Golgi network Note=Located in the trans-Golgi in the GTP-bound active state. Disruption of the gene leads to embryonic lethality during early gastrulation. Intestine-specific knockout mice display severe growth retardation due to reduced fat absorption and decrease in lipid release from the intestinal epithelium to the lymph and blood. Liver-specific knockout mice display impaired VLDL lipidation leading to reduced plasma triglyceride levels in the fasted state. Liver-specific knockout mice also display a disturbed glucose metabolism caused by a reduced plasma membrane localization of the glucose transporter GLUT2. Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTPase activity GTP binding Golgi apparatus trans-Golgi network cytosol intracellular protein transport gastrulation membrane protein localization to Golgi apparatus retrograde transport, endosome to Golgi Golgi to plasma membrane protein transport uc008olz.1 uc008olz.2 uc008olz.3 uc008olz.4 
ENSMUST00000127990.9 Gm16120 ENSMUST00000127990.9 Gm16120 (from geneSymbol) BC046508 ENSMUST00000127990.1 ENSMUST00000127990.2 ENSMUST00000127990.3 ENSMUST00000127990.4 ENSMUST00000127990.5 ENSMUST00000127990.6 ENSMUST00000127990.7 ENSMUST00000127990.8 uc009ahl.1 uc009ahl.2 uc009ahl.3 uc009ahl.4 uc009ahl.1 uc009ahl.2 uc009ahl.3 uc009ahl.4 
ENSMUST00000128026.4 2500004C02Rik ENSMUST00000128026.4 RIKEN cDNA 2500004C02 gene (from RefSeq NR_040318.1) ENSMUST00000128026.1 ENSMUST00000128026.2 ENSMUST00000128026.3 NR_040318 uc008nhr.1 uc008nhr.2 uc008nhr.3 uc008nhr.4 uc008nhr.5 uc008nhr.1 uc008nhr.2 uc008nhr.3 uc008nhr.4 uc008nhr.5 
ENSMUST00000128041.8 Mfsd13a ENSMUST00000128041.8 Membrane ; Multi-pass membrane protein (from UniProt Q6PDE8) AK170247 ENSMUST00000128041.1 ENSMUST00000128041.2 ENSMUST00000128041.3 ENSMUST00000128041.4 ENSMUST00000128041.5 ENSMUST00000128041.6 ENSMUST00000128041.7 MF13A_MOUSE Mfsd13a Q6PDE8 Q80Y49 Q8CD35 Tmem180 uc289sgx.1 uc289sgx.2 Membrane ; Multi-pass membrane protein Sequence=BAC27447.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc289sgx.1 uc289sgx.2 
ENSMUST00000128053.2 Gm14617 ENSMUST00000128053.2 Gm14617 (from geneSymbol) ENSMUST00000128053.1 uc290dbg.1 uc290dbg.2 uc290dbg.1 uc290dbg.2 
ENSMUST00000128088.4 Saa1 ENSMUST00000128088.4 serum amyloid A 1, transcript variant 1 (from RefSeq NM_009117.4) ENSMUST00000128088.1 ENSMUST00000128088.2 ENSMUST00000128088.3 NM_009117 Q5I0U6 Q5I0U6_MOUSE Saa1 uc009gyz.1 uc009gyz.2 uc009gyz.3 Major acute phase reactant. Apolipoprotein of the HDL complex. Belongs to the SAA family. extracellular region acute-phase response high-density lipoprotein particle uc009gyz.1 uc009gyz.2 uc009gyz.3 
ENSMUST00000128101.9 Ccdc63 ENSMUST00000128101.9 coiled-coil domain containing 63, transcript variant 8 (from RefSeq NM_001384201.1) Ccdc63 D3YUZ2 D3YUZ2_MOUSE ENSMUST00000128101.1 ENSMUST00000128101.2 ENSMUST00000128101.3 ENSMUST00000128101.4 ENSMUST00000128101.5 ENSMUST00000128101.6 ENSMUST00000128101.7 ENSMUST00000128101.8 NM_001384201 uc290zis.1 uc290zis.2 uc290zis.3 uc290zis.1 uc290zis.2 uc290zis.3 
ENSMUST00000128102.4 Gm28308 ENSMUST00000128102.4 Gm28308 (from geneSymbol) AK051552 ENSMUST00000128102.1 ENSMUST00000128102.2 ENSMUST00000128102.3 uc291emb.1 uc291emb.2 uc291emb.1 uc291emb.2 
ENSMUST00000128111.2 Gm11532 ENSMUST00000128111.2 predicted gene 11532 (from RefSeq NR_133649.1) ENSMUST00000128111.1 NR_133649 uc007ldj.1 uc007ldj.2 uc007ldj.3 uc007ldj.1 uc007ldj.2 uc007ldj.3 
ENSMUST00000128119.2 Megf8 ENSMUST00000128119.2 multiple EGF-like-domains 8 (from RefSeq NM_001160400.1) B3GR00 ENSMUST00000128119.1 Egfl4 MEGF8_MOUSE NM_001160400 P60882 Q80TR3 Q80V41 Q8BMN9 Q8JZW7 Q8K0J3 uc009fsj.1 uc009fsj.2 uc009fsj.3 Acts as a negative regulator of hedgehog signaling (PubMed:29290584). Membrane ; Single-pass type I membrane protein Highest expression in brain, testis and kidney. Sequence=AAH36727.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=AAH51121.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence=; embryonic heart tube morphogenesis molecular_function calcium ion binding nucleus determination of left/right symmetry animal organ morphogenesis tissue development regulation of gene expression membrane integral component of membrane embryonic limb morphogenesis BMP signaling pathway limb morphogenesis cell migration involved in gastrulation negative regulation of smoothened signaling pathway embryonic skeletal system morphogenesis positive regulation of axon extension involved in axon guidance epiboly involved in gastrulation with mouth forming second embryonic heart tube left/right pattern formation left/right pattern formation coronary vasculature development determination of heart left/right asymmetry determination of digestive tract left/right asymmetry craniofacial suture morphogenesis fasciculation of sensory neuron axon uc009fsj.1 uc009fsj.2 uc009fsj.3 
ENSMUST00000128125.4 Gm10658 ENSMUST00000128125.4 Gm10658 (from geneSymbol) AK143982 ENSMUST00000128125.1 ENSMUST00000128125.2 ENSMUST00000128125.3 uc009ptu.1 uc009ptu.2 uc009ptu.3 uc009ptu.4 uc009ptu.5 uc009ptu.6 uc009ptu.1 uc009ptu.2 uc009ptu.3 uc009ptu.4 uc009ptu.5 uc009ptu.6 
ENSMUST00000128165.2 Rapgef4os2 ENSMUST00000128165.2 Rapgef4os2 (from geneSymbol) AK079188 ENSMUST00000128165.1 uc008kbr.1 uc008kbr.2 uc008kbr.1 uc008kbr.2 
ENSMUST00000128166.8 Zdhhc2 ENSMUST00000128166.8 Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:15603741). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (PubMed:25589740). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (PubMed:15603741). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase- activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (PubMed:21343290). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function. Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane. Could also palmitoylate LCK and regulate its localization to the plasma membrane (By similarity). (from UniProt P59267) AK018284 ENSMUST00000128166.1 ENSMUST00000128166.2 ENSMUST00000128166.3 ENSMUST00000128166.4 ENSMUST00000128166.5 ENSMUST00000128166.6 ENSMUST00000128166.7 P59267 ZDHC2_MOUSE Zdhhc2 uc291zlb.1 uc291zlb.2 Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:15603741). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (PubMed:25589740). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (PubMed:15603741). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase- activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (PubMed:21343290). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function. Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane. Could also palmitoylate LCK and regulate its localization to the plasma membrane (By similarity). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Reaction=L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S- tetradecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59736, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:15433, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:143199; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59737; Evidence=; Reaction=L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S- octadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59740, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:15434, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:143200; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59741; Evidence=; Monomer. Homodimer. The monomeric form has a higher catalytic activity. Postsynaptic density Postsynaptic recycling endosome membrane ; Multi-pass membrane protein Cell membrane ulti-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Note=Translocates to postsynaptic density when synaptic activity decreases. Expressed in all brain regions. The DHHC domain is required for palmitoyltransferase activity. Autopalmitoylated. Belongs to the DHHC palmitoyltransferase family. endoplasmic reticulum Golgi apparatus integral component of plasma membrane protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity recycling endosome membrane uc291zlb.1 uc291zlb.2 
ENSMUST00000128183.4 Gm11690 ENSMUST00000128183.4 Gm11690 (from geneSymbol) AK041521 ENSMUST00000128183.1 ENSMUST00000128183.2 ENSMUST00000128183.3 uc288dhy.1 uc288dhy.2 uc288dhy.3 uc288dhy.4 uc288dhy.1 uc288dhy.2 uc288dhy.3 uc288dhy.4 
ENSMUST00000128187.8 Hnrnpdl ENSMUST00000128187.8 heterogeneous nuclear ribonucleoprotein D-like, transcript variant 1 (from RefSeq NM_016690.5) D3YTQ3 D3YTQ3_MOUSE ENSMUST00000128187.1 ENSMUST00000128187.2 ENSMUST00000128187.3 ENSMUST00000128187.4 ENSMUST00000128187.5 ENSMUST00000128187.6 ENSMUST00000128187.7 Hnrnpdl NM_016690 uc008ygy.1 uc008ygy.2 uc008ygy.3 Cytoplasm Nucleus nucleic acid binding RNA binding nucleoplasm uc008ygy.1 uc008ygy.2 uc008ygy.3 
ENSMUST00000128214.3 Gm11415 ENSMUST00000128214.3 Gm11415 (from geneSymbol) ENSMUST00000128214.1 ENSMUST00000128214.2 KY467986 uc290nno.1 uc290nno.2 uc290nno.3 uc290nno.1 uc290nno.2 uc290nno.3 
ENSMUST00000128235.2 Gm16095 ENSMUST00000128235.2 Gm16095 (from geneSymbol) ENSMUST00000128235.1 uc292gen.1 uc292gen.2 uc292gen.1 uc292gen.2 
ENSMUST00000128240.2 Gm15345 ENSMUST00000128240.2 Gm15345 (from geneSymbol) ENSMUST00000128240.1 uc289peq.1 uc289peq.2 uc289peq.1 uc289peq.2 
ENSMUST00000128241.8 Aire ENSMUST00000128241.8 autoimmune regulator, transcript variant 1 (from RefSeq NM_009646.2) AIRE_MOUSE ENSMUST00000128241.1 ENSMUST00000128241.2 ENSMUST00000128241.3 ENSMUST00000128241.4 ENSMUST00000128241.5 ENSMUST00000128241.6 ENSMUST00000128241.7 NM_009646 Q9JLW0 Q9JLW1 Q9JLW2 Q9JLW3 Q9JLW4 Q9JLW5 Q9JLW6 Q9JLW7 Q9JLW8 Q9JLW9 Q9JLX0 Q9Z0E3 uc007fwr.1 uc007fwr.2 uc007fwr.3 uc007fwr.4 Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue- restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (Probable). Binds to G-doublets in an A/T- rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (By similarity). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program (PubMed:19015306). Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression (PubMed:21300913). Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes (PubMed:19923453). In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection (PubMed:26070482). In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (PubMed:23993652). Homodimer and homotetramer. Interacts with CREBBP. Interacts preferentially with histone H3 that is not methylated at 'Lys-4'. Binds with lower affinity to histone H3 that is monomethylated at 'Lys-4'. Trimethylation of histone H3 at 'Lys-4' or phosphorylation at 'Thr-3' abolish the interaction. Binds with lower affinity to histone H3 that is acetylated at 'Lys-4', or that is acetylated at 'Lys-9' or trimethylated at 'Lys-9'. Binds histone H3 that is dimethylated at 'Arg-2' with very low affinity (By similarity). Q9Z0E3; Q9Z0E3: Aire; NbExp=4; IntAct=EBI-80858, EBI-80858; Nucleus toplasm Note=Predominantly nuclear but also cytoplasmic. Found in nuclear body-like structures (dots) and in a filamentous vimentin-like pattern. Event=Alternative splicing; Named isoforms=12; Comment=Additional isoforms seem to exist.; Name=1a; IsoId=Q9Z0E3-1; Sequence=Displayed; Name=1b; IsoId=Q9Z0E3-2; Sequence=VSP_004092; Name=1c; IsoId=Q9Z0E3-3; Sequence=VSP_004091; Name=1d; IsoId=Q9Z0E3-4; Sequence=VSP_004091, VSP_004092; Name=2a; IsoId=Q9Z0E3-5; Sequence=VSP_004093; Name=2b; IsoId=Q9Z0E3-6; Sequence=VSP_004092, VSP_004093; Name=2c; IsoId=Q9Z0E3-7; Sequence=VSP_004091, VSP_004093; Name=2d; IsoId=Q9Z0E3-8; Sequence=VSP_004091, VSP_004092, VSP_004093; Name=3a; IsoId=Q9Z0E3-9; Sequence=VSP_004094, VSP_004095; Name=3b; IsoId=Q9Z0E3-10; Sequence=VSP_004092, VSP_004094, VSP_004095; Name=3c; IsoId=Q9Z0E3-11; Sequence=VSP_004091, VSP_004094, VSP_004095; Name=3d; IsoId=Q9Z0E3-12; Sequence=VSP_004091, VSP_004092, VSP_004094, VSP_004095; Highly expressed in a few cells in the medulla of the thymus (medullary epithelial cells) (at protein level) (PubMed:23993652). Expressed in thymic but no peripheral B-cells (PubMed:26070482). In secondary lymphoid organs, expressed in a discrete population of bone marrow-derived toleregenic antigen presenting cells (APCs) called extrathymic AIRE expressing cells (eTAC)(at protein level) (PubMed:23993652). Detected at very low levels in thymus, lymph node, liver, brain, ovary, lung, testis, kidney, heart, spleen, bone marrow, skeletal muscle and adrenal gland. Isoforms 1a to 1d predominate, isoforms 2a to 2d are intermediate and isoforms 3a to 3d are expressed at extremely low levels. In the thymus, not expressed at 13.5 dpc but present at 16.5 dpc and postnatal day 1. Interacts via the first PHD domain with the N-terminus of histone H3 that is not methylated at 'Lys-4'. Disruption of the first PHD domain has been shown to lead to reduced transcriptional activity and to localization of the protein mainly in the cytoplasm in small granules. While the PHD zinc fingers are necessary for the transactivation capacity of the protein, other regions also modulate this function (By similarity). The L-X-X-L-L repeats may be implicated in binding to nuclear receptors. The N-terminal HSR domain is required for localization on tubular structures. Phosphorylated. Deficient mice show an altered thymic organization with altered morphology and location of mTECs (PubMed:19015306). They exhibit defective accumulation of thymic dendritic cells in the medullary region and generation of naturally ocurring T cells in the thymus (PubMed:21300913). [Isoform 3a]: Probably inactive. [Isoform 3b]: Probably inactive. [Isoform 3c]: Probably inactive. [Isoform 3d]: Probably inactive. RNA polymerase II regulatory region sequence-specific DNA binding peripheral T cell tolerance induction central tolerance induction to self antigen DNA binding chromatin binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of translation humoral immune response zinc ion binding nuclear body chemokine production histone binding identical protein binding transcription regulatory region DNA binding negative thymic T cell selection translation regulator activity positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding thymus epithelium morphogenesis regulation of thymocyte migration uc007fwr.1 uc007fwr.2 uc007fwr.3 uc007fwr.4 
ENSMUST00000128247.2 Rdh16f1 ENSMUST00000128247.2 Belongs to the short-chain dehydrogenases/reductases (SDR) family. (from UniProt E9Q9P8) AK132181 E9Q9P8 E9Q9P8_MOUSE ENSMUST00000128247.1 Gm28046 Rdh16f1 Rdh9 uc007hko.1 uc007hko.2 uc007hko.3 uc007hko.4 Belongs to the short-chain dehydrogenases/reductases (SDR) family. oxidoreductase activity oxidation-reduction process uc007hko.1 uc007hko.2 uc007hko.3 uc007hko.4 
ENSMUST00000128259.9 4932414N04Rik ENSMUST00000128259.9 RIKEN cDNA 4932414N04 gene (from RefSeq NM_183113.3) 4932414N04Rik ENSMUST00000128259.1 ENSMUST00000128259.2 ENSMUST00000128259.3 ENSMUST00000128259.4 ENSMUST00000128259.5 ENSMUST00000128259.6 ENSMUST00000128259.7 ENSMUST00000128259.8 H3BLH7 NM_183113 Q8CEQ9 Q8CEQ9_MOUSE uc008jxr.1 uc008jxr.2 uc008jxr.3 molecular_function cellular_component biological_process uc008jxr.1 uc008jxr.2 uc008jxr.3 
ENSMUST00000128274.3 Gm11587 ENSMUST00000128274.3 Gm11587 (from geneSymbol) AK135711 ENSMUST00000128274.1 ENSMUST00000128274.2 uc287ipu.1 uc287ipu.2 uc287ipu.1 uc287ipu.2 
ENSMUST00000128302.8 Smyd3 ENSMUST00000128302.8 SET and MYND domain containing 3 (from RefSeq NM_027188.4) ENSMUST00000128302.1 ENSMUST00000128302.2 ENSMUST00000128302.3 ENSMUST00000128302.4 ENSMUST00000128302.5 ENSMUST00000128302.6 ENSMUST00000128302.7 NM_027188 Q6P7V6 Q8BG90 Q9CWR2 SMYD3_MOUSE Zmynd1 uc007dvj.1 uc007dvj.2 uc007dvj.3 uc007dvj.4 Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Lys-5' of histone H4. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. Reaction=L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60260, Rhea:RHEA-COMP:15537, Rhea:RHEA- COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.354; Evidence= Histone methyltransferase activity strongly stimulated by HSPCA. Interacts with HSPCA. Interacts with HELZ. Interacts with POLR2A; the interaction may be indirect and may be mediated by HELZ. Interacts with HSP90AA1; this interaction enhances SMYD3 histone-lysine N-methyltransferase. Cytoplasm Nucleus Note=Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol chromatin organization nucleosome assembly negative regulation of protein kinase activity methyltransferase activity myotube cell development transferase activity histone-lysine N-methyltransferase activity methylation positive regulation of peptidyl-serine phosphorylation histone lysine methylation establishment of protein localization positive regulation of transcription from RNA polymerase II promoter metal ion binding cellular response to dexamethasone stimulus uc007dvj.1 uc007dvj.2 uc007dvj.3 uc007dvj.4 
ENSMUST00000128307.2 Gm14033 ENSMUST00000128307.2 Gm14033 (from geneSymbol) AK036371 ENSMUST00000128307.1 uc008jrt.1 uc008jrt.2 uc008jrt.1 uc008jrt.2 
ENSMUST00000128327.2 Gm10706 ENSMUST00000128327.2 Gm10706 (from geneSymbol) AK138480 ENSMUST00000128327.1 uc292env.1 uc292env.2 uc292env.1 uc292env.2 
ENSMUST00000128342.3 Gm16576 ENSMUST00000128342.3 predicted gene 16576 (from RefSeq NR_045069.1) ENSMUST00000128342.1 ENSMUST00000128342.2 NR_045069 uc029sto.1 uc029sto.2 uc029sto.3 uc029sto.1 uc029sto.2 uc029sto.3 
ENSMUST00000128353.8 Ankrd9 ENSMUST00000128353.8 Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly. Implicated in different cellular processes, like copper homeostasis and cell proliferation. (from UniProt Q8BH83) AK051108 ANKR9_MOUSE ENSMUST00000128353.1 ENSMUST00000128353.2 ENSMUST00000128353.3 ENSMUST00000128353.4 ENSMUST00000128353.5 ENSMUST00000128353.6 ENSMUST00000128353.7 Q3TA09 Q8BH83 Q8BHR3 uc007pci.1 uc007pci.2 uc007pci.3 Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly. Implicated in different cellular processes, like copper homeostasis and cell proliferation. Protein modification; protein ubiquitination. Part of an E3 ubiquitin-protein ligase complex with Elongin BC (ELOB and ELOC), CUL5 and ANKRD9. Interacts with IMPDH2; leading to ubiquitination of IMPDH2 and its subsequent proteasomal degradation. Cytoplasmic vesicle Cytoplasm, cytosol Note=Detected in long filamentous cytosolic structures where it colocalizes with IMPDH2. Under basal conditions ANKRD9 is mainly in vesicle-like structures, upon nutrient limitation (guanine nucleotides deficiency) ANKRD9 loses its vesicular pattern and assembles with IMPDH2 into rodlike filaments. hydrolase activity uc007pci.1 uc007pci.2 uc007pci.3 
ENSMUST00000128361.3 Pabpc1l2a ENSMUST00000128361.3 poly(A) binding protein, cytoplasmic 1-like 2A (from RefSeq NM_001384266.2) ENSMUST00000128361.1 ENSMUST00000128361.2 NM_001384266 uc292pvs.1 uc292pvs.2 uc292pvs.3 uc292pvs.1 uc292pvs.2 uc292pvs.3 
ENSMUST00000128368.2 Ctrcos ENSMUST00000128368.2 chymotrypsin C, opposite strand (from RefSeq NR_040641.1) ENSMUST00000128368.1 NR_040641 uc029vah.1 uc029vah.2 uc029vah.1 uc029vah.2 
ENSMUST00000128385.2 Gm13053 ENSMUST00000128385.2 Gm13053 (from geneSymbol) ENSMUST00000128385.1 uc290rkz.1 uc290rkz.2 uc290rkz.1 uc290rkz.2 
ENSMUST00000128402.3 Kif26a ENSMUST00000128402.3 kinesin family member 26A (from RefSeq NM_001097621.1) C9EF47 ENSMUST00000128402.1 ENSMUST00000128402.2 KI26A_MOUSE Kiaa1236 NM_001097621 Q52KG5 Q6PCY3 Q6ZPV4 Q99PT4 uc007pem.1 uc007pem.2 Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (PubMed:19914172). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). Interacts with GRB2 (via SH2 domain). Q52KG5; Q60631: Grb2; NbExp=2; IntAct=EBI-2480646, EBI-1688; Cytoplasm, cytoskeleton Expressed in several neuronal populations. Strong expression is detected in substantia nigra in brain and enteric nervous system in colon at P12. In colon sections at 12.5 dpc, 14.5 dpc, and P12, it is exclusively expressed in enteric nervous system (ENS). Also detected in dorsal root ganglion and spinal cord gray matter at 14.5 dpc. Mice exhibit growth retardation, become emaciated, and die within 5 weeks of birth. The median and mean life span is 15 and 16 days. Macroscopic dissection reveal that mice suffered from megacolon, with dilation from the distal small intestine to the proximal colon and display enteric nerve hyperplasia. Severe occlusion are observed in the distal colon, because the colon motility is not coordinated. Defects are due to abnormal enteric nervous system (ENS) proliferation. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily. In contrast to other kinesin-like proteins, residues required for ATPase activity are missing. nucleotide binding regulation of cell growth by extracellular stimulus microtubule motor activity protein binding ATP binding cytoplasm cytoskeleton kinesin complex microtubule microtubule binding ATP-dependent microtubule motor activity, plus-end-directed negative regulation of signal transduction enteric nervous system development microtubule-based movement ATPase activity uc007pem.1 uc007pem.2 
ENSMUST00000128415.3 Gm15619 ENSMUST00000128415.3 Gm15619 (from geneSymbol) ENSMUST00000128415.1 ENSMUST00000128415.2 uc292kkq.1 uc292kkq.2 uc292kkq.1 uc292kkq.2 
ENSMUST00000128445.9 Catip ENSMUST00000128445.9 ciliogenesis associated TTC17 interacting protein, transcript variant 1 (from RefSeq NM_001379457.1) Catip ENSMUST00000128445.1 ENSMUST00000128445.2 ENSMUST00000128445.3 ENSMUST00000128445.4 ENSMUST00000128445.5 ENSMUST00000128445.6 ENSMUST00000128445.7 ENSMUST00000128445.8 F7AAT1 F7AAT1_MOUSE NM_001379457 uc287jee.1 uc287jee.2 uc287jee.3 Plays a role in primary ciliogenesis by modulating actin polymerization. Cell membrane Cytoplasm, cytoskeleton Membrane Nucleus Belongs to the CATIP family. uc287jee.1 uc287jee.2 uc287jee.3 
ENSMUST00000128520.2 Gm16121 ENSMUST00000128520.2 Gm16121 (from geneSymbol) AK043560 ENSMUST00000128520.1 uc291bhd.1 uc291bhd.2 uc291bhd.1 uc291bhd.2 
ENSMUST00000128521.2 Gm12243 ENSMUST00000128521.2 Gm12243 (from geneSymbol) ENSMUST00000128521.1 uc287yhy.1 uc287yhy.2 uc287yhy.1 uc287yhy.2 
ENSMUST00000128545.3 2210411M09Rik ENSMUST00000128545.3 2210411M09Rik (from geneSymbol) AK008903 ENSMUST00000128545.1 ENSMUST00000128545.2 uc287omi.1 uc287omi.2 uc287omi.1 uc287omi.2 
ENSMUST00000128563.3 Gm13028 ENSMUST00000128563.3 Gm13028 (from geneSymbol) ENSMUST00000128563.1 ENSMUST00000128563.2 uc290rfp.1 uc290rfp.2 uc290rfp.3 uc290rfp.1 uc290rfp.2 uc290rfp.3 
ENSMUST00000128569.4 2900005J15Rik ENSMUST00000128569.4 2900005J15Rik (from geneSymbol) AK015504 ENSMUST00000128569.1 ENSMUST00000128569.2 ENSMUST00000128569.3 uc290ttp.1 uc290ttp.2 uc290ttp.3 uc290ttp.4 uc290ttp.1 uc290ttp.2 uc290ttp.3 uc290ttp.4 
ENSMUST00000128570.9 Rreb1 ENSMUST00000128570.9 ras responsive element binding protein 1, transcript variant 10 (from RefSeq NM_001404760.1) B8JJE2 B8JJE3 ENSMUST00000128570.1 ENSMUST00000128570.2 ENSMUST00000128570.3 ENSMUST00000128570.4 ENSMUST00000128570.5 ENSMUST00000128570.6 ENSMUST00000128570.7 ENSMUST00000128570.8 NM_001404760 Q3TB97 Q3UH06 Q4ZE88 Q66JZ8 RREB1_MOUSE uc007qdb.1 uc007qdb.2 uc007qdb.3 uc007qdb.4 Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters (PubMed:12700664). Represses the angiotensinogen gene (By similarity). Negatively regulates the transcriptional activity of AR (By similarity). Potentiates the transcriptional activity of NEUROD1 (By similarity). Binds specifically to the allelic variant of the CDKN2A promoter present in Balb/c mice, which leads to a down-regulation of CDKN2A expression in this strain, and, as a consequence, to an elevated susceptibility to pristane-induced tumors (PubMed:12700664). Promotes brown adipocyte differentiation (PubMed:27923061). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (By similarity). Interacts with NEUROD1 (By similarity). Interacts with AR (By similarity). Nucleus speckle Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3UH06-1; Sequence=Displayed; Name=2; IsoId=Q3UH06-2; Sequence=VSP_026765; Name=3; IsoId=Q3UH06-3; Sequence=VSP_026766; Name=4; IsoId=Q3UH06-4; Sequence=VSP_026767, VSP_026768; Expressed in splenic B-cells. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding fibrillar center nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus positive regulation of epithelial cell migration nuclear speck positive regulation of mammary gland epithelial cell proliferation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of substrate adhesion-dependent cell spreading positive regulation of wound healing, spreading of epidermal cells positive regulation of lamellipodium morphogenesis uc007qdb.1 uc007qdb.2 uc007qdb.3 uc007qdb.4 
ENSMUST00000128577.2 Gm14164 ENSMUST00000128577.2 predicted gene 14164 (from RefSeq NR_033505.1) ENSMUST00000128577.1 NR_033505 uc008nfg.1 uc008nfg.2 uc008nfg.3 uc008nfg.4 uc008nfg.1 uc008nfg.2 uc008nfg.3 uc008nfg.4 
ENSMUST00000128601.2 A930104D05Rik ENSMUST00000128601.2 A930104D05Rik (from geneSymbol) AK040510 ENSMUST00000128601.1 uc008lrt.1 uc008lrt.2 uc008lrt.1 uc008lrt.2 
ENSMUST00000128608.2 A130030D18Rik ENSMUST00000128608.2 RIKEN cDNA A130030D18 gene (from RefSeq NR_152125.1) ENSMUST00000128608.1 NR_152125 uc008khw.1 uc008khw.2 uc008khw.3 uc008khw.1 uc008khw.2 uc008khw.3 
ENSMUST00000128616.6 Malsu1 ENSMUST00000128616.6 mitochondrial assembly of ribosomal large subunit 1 (from RefSeq NM_029353.1) ENSMUST00000128616.1 ENSMUST00000128616.2 ENSMUST00000128616.3 ENSMUST00000128616.4 ENSMUST00000128616.5 MASU1_MOUSE NM_029353 Q9CWV0 uc009bwg.1 uc009bwg.2 uc009bwg.3 uc009bwg.4 Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor. Associates with the mitochondrial ribosome large subunit (39S) via interaction with MRPL12 and/or MRPL14. The interaction generates steric hindrance that is expected to prevent premature association of the 28S and 39S ribosomal subunits. Identified in a complex composed of MALSU1, MIEF1 upstream open reading frame protein and NDUFAB1; within the trimeric complex, MIEF1 upstream open reading frame protein functions as a bridging scaffold that interacts with MALSU1 on one side, and with NDUFAB1 on the other side. Interacts with MRPL12 and MRPL14. Mitochondrion matrix Note=Colocalizes with MRPL12 and/or MRPL14. Belongs to the Iojap/RsfS family. mitochondrion mitochondrial matrix mitochondrial large ribosomal subunit cytosol negative regulation of translation ribosome biogenesis ribosomal large subunit biogenesis ribosomal large subunit binding negative regulation of mitochondrial translation negative regulation of ribosome biogenesis uc009bwg.1 uc009bwg.2 uc009bwg.3 uc009bwg.4 
ENSMUST00000128646.8 Phactr1 ENSMUST00000128646.8 phosphatase and actin regulator 1, transcript variant 4 (from RefSeq NM_001302635.1) B1B1B5 B1B1B6 B1B1B7 ENSMUST00000128646.1 ENSMUST00000128646.2 ENSMUST00000128646.3 ENSMUST00000128646.4 ENSMUST00000128646.5 ENSMUST00000128646.6 ENSMUST00000128646.7 G5E8P7 NM_001302635 PHAR1_MOUSE Q2M3X8 Q80VL9 Q8C873 uc007qfo.1 uc007qfo.2 uc007qfo.3 uc007qfo.4 uc007qfo.5 Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization (PubMed:30256902). Interacts (via RPEL repeats) with ACTA1 and PPP1CA; ACTA1 and PPP1CA compete for the same binding site. Cytoplasm. Synapse Nucleus. Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q2M3X8-1; Sequence=Displayed; Name=2; IsoId=Q2M3X8-2; Sequence=VSP_018559; Name=3; IsoId=Q2M3X8-3; Sequence=VSP_018559, VSP_018560; Name=4; IsoId=Q2M3X8-4; Sequence=VSP_018560; Binds three actin monomers via the three C-terminal RPEL repeats. PHACTR1 knockdown results in migration defects of cortical neurons. Neurons do not migrate to layers II-IV of the cortical plate but remain in the lower part and the intermediate zone. Belongs to the phosphatase and actin regulator family. Sequence=AAH48407.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH61691.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC33272.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; actin binding protein phosphatase inhibitor activity nucleus cytoplasm cytosol protein phosphatase 1 binding protein phosphatase regulator activity cerebral cortex development cell junction actomyosin structure organization actin cytoskeleton reorganization negative regulation of phosphoprotein phosphatase activity regulation of phosphorylation stress fiber assembly regulation of phosphoprotein phosphatase activity synapse cell motility regulation of neuron migration uc007qfo.1 uc007qfo.2 uc007qfo.3 uc007qfo.4 uc007qfo.5 
ENSMUST00000128647.3 Lrrc75aos2 ENSMUST00000128647.3 Lrrc75aos2 (from geneSymbol) AK015368 ENSMUST00000128647.1 ENSMUST00000128647.2 uc287yxa.1 uc287yxa.2 uc287yxa.3 uc287yxa.1 uc287yxa.2 uc287yxa.3 
ENSMUST00000128657.9 Gm14418 ENSMUST00000128657.9 May be involved in transcriptional regulation. (from UniProt A2ARR6) A2ARR6 A2ARR6_MOUSE BC092145 ENSMUST00000128657.1 ENSMUST00000128657.2 ENSMUST00000128657.3 ENSMUST00000128657.4 ENSMUST00000128657.5 ENSMUST00000128657.6 ENSMUST00000128657.7 ENSMUST00000128657.8 Gm14418 uc290dfx.1 uc290dfx.2 uc290dfx.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290dfx.1 uc290dfx.2 uc290dfx.3 
ENSMUST00000128667.8 Fktn ENSMUST00000128667.8 fukutin, transcript variant 1 (from RefSeq NM_139309.5) ENSMUST00000128667.1 ENSMUST00000128667.2 ENSMUST00000128667.3 ENSMUST00000128667.4 ENSMUST00000128667.5 ENSMUST00000128667.6 ENSMUST00000128667.7 FKTN_MOUSE Fcmd Fktn NM_139309 Q8R507 Q8VD64 uc008sxe.1 uc008sxe.2 uc008sxe.3 Catalyzes the transfer of CDP-ribitol to the distal N- acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate- 6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:12471058). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (By similarity). Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity (PubMed:19017726). May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes (PubMed:19017726, PubMed:22922256). Could be involved in brain development (Probable). Reaction=3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D- Man)]-Thr-[protein] + CDP-L-ribitol = 3-O-[Rib-ol-P-3-beta-D-GalNAc- (1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+); Xref=Rhea:RHEA:36551, Rhea:RHEA-COMP:13309, Rhea:RHEA- COMP:17480, ChEBI:CHEBI:15378, ChEBI:CHEBI:57608, ChEBI:CHEBI:60377, ChEBI:CHEBI:136710, ChEBI:CHEBI:177331; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36552; Evidence=; Protein modification; protein glycosylation. Forms a complex composed of FKTN/fukutin, FKRP and RXYLT1/TMEM5 (By similarity). Interacts (via transmembrane domain) with POMGNT1; the interaction is direct and is required for normal POMGNT1 location in Golgi membranes (By similarity). Golgi apparatus membrane ; Single-pass type II membrane protein Cytoplasm Nucleus Endoplasmic reticulum Note=In retinal tissue, does not localize with the Golgi apparatus. Expressed in the retina, with highest levels found in the inner segments of photoreceptors and the outer plexiform layer (at protein level) (PubMed:29416295). Expressed at lower levels in the inner and outer nuclear layers, the inner plexiform layers, and the ganglion cell layers of the retina (at protein level) (PubMed:29416295). Expressed in the heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis (PubMed:12471058, PubMed:12408965). Wide distribution of expression throughout embryonic development, most predominantly in the central and peripheral nervous systems. High expression in the ventricular zone of proliferating neurons at 13.5 dpc. Broadly expressed in late embryonic and early postnatal cerebellar neurons, including premigratory granule neurons of the external granule cell layer. Expression is maintained in neurons of the internal granule cell layer after migration is complete. Intense expression in Purkinje cells throughout development. A unique pattern of intense expression in irregularly spaced cell bodies that do not appear to correlate with known parasagittal stripes. Expressed in Bergmann glial scaffolds used by granule cells during early posnatal radial migration. Embryonic lethality (PubMed:19017726). However, when human FCMD disease-causing retrotransposon is introduced into the mouse fukutin gene, alpha-dystroglycan/DAG1 is hypoglycosylated in muscles as is seen in FCMD (congenital muscular dystrophy Fukuyama) patients. Transfer of normal fukutin gene into these knockin mice restores glycosylation of alpha-dystroglycan (PubMed:19017726). Conditional knockout in muscle results in near absence of glycosylated dystroglycan within 18 days of gene deletion. 20 week-old knockout mice show clear dystrophic histopathology and defects in glycosylation near the dystroglycan O-mannose phosphate when excision driven by muscle- specific promoters takes place at 8 dpc or 17 dpc. Earlier gene deletion causes more severe phenotypes (PubMed:22922256). Belongs to the LicD transferase family. Golgi membrane neuron migration nucleus cytoplasm endoplasmic reticulum Golgi apparatus cis-Golgi network protein glycosylation protein O-linked glycosylation negative regulation of cell proliferation membrane integral component of membrane transferase activity integral component of Golgi membrane protein O-linked mannosylation negative regulation of JNK cascade regulation of protein glycosylation uc008sxe.1 uc008sxe.2 uc008sxe.3 
ENSMUST00000128675.3 Cdrt4os2 ENSMUST00000128675.3 CMT1A duplicated region transcript 4, opposite strand 2 (from RefSeq NR_175379.1) ENSMUST00000128675.1 ENSMUST00000128675.2 NR_175379 uc287yyj.1 uc287yyj.2 uc287yyj.3 uc287yyj.1 uc287yyj.2 uc287yyj.3 
ENSMUST00000128681.3 Gm14222 ENSMUST00000128681.3 Gm14222 (from geneSymbol) ENSMUST00000128681.1 ENSMUST00000128681.2 uc290cfc.1 uc290cfc.2 uc290cfc.3 uc290cfc.1 uc290cfc.2 uc290cfc.3 
ENSMUST00000128728.3 Gm15690 ENSMUST00000128728.3 Gm15690 (from geneSymbol) ENSMUST00000128728.1 ENSMUST00000128728.2 uc290zbz.1 uc290zbz.2 uc290zbz.3 uc290zbz.1 uc290zbz.2 uc290zbz.3 
ENSMUST00000128743.3 Gm13376 ENSMUST00000128743.3 Gm13376 (from geneSymbol) AK045682 ENSMUST00000128743.1 ENSMUST00000128743.2 uc289tmh.1 uc289tmh.2 uc289tmh.3 uc289tmh.1 uc289tmh.2 uc289tmh.3 
ENSMUST00000128751.3 Ccdc167 ENSMUST00000128751.3 coiled-coil domain containing 167, transcript variant 2 (from RefSeq NM_026782.2) CC167_MOUSE ENSMUST00000128751.1 ENSMUST00000128751.2 NM_026782 Q8BQL8 Q8C3L9 Q8R1Y8 Q9D162 uc008btk.1 uc008btk.2 uc008btk.3 uc008btk.4 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D162-1; Sequence=Displayed; Name=2; IsoId=Q9D162-2; Sequence=VSP_028986; Name=3; IsoId=Q9D162-3; Sequence=VSP_028985; [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=AAH22730.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB23065.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC33728.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008btk.1 uc008btk.2 uc008btk.3 uc008btk.4 
ENSMUST00000128764.9 Sap18 ENSMUST00000128764.9 Sin3-associated polypeptide 18 (from RefSeq NM_009119.3) E9Q317 E9Q317_MOUSE ENSMUST00000128764.1 ENSMUST00000128764.2 ENSMUST00000128764.3 ENSMUST00000128764.4 ENSMUST00000128764.5 ENSMUST00000128764.6 ENSMUST00000128764.7 ENSMUST00000128764.8 NM_009119 Sap18 Sap18b uc007udo.1 uc007udo.2 uc007udo.3 uc007udo.4 Belongs to the SAP18 family. nucleoplasm cytosol biological_process nuclear body nuclear speck ASAP complex exon-exon junction complex uc007udo.1 uc007udo.2 uc007udo.3 uc007udo.4 
ENSMUST00000128788.8 Ift20 ENSMUST00000128788.8 intraflagellar transport 20 (from RefSeq NM_018854.5) ENSMUST00000128788.1 ENSMUST00000128788.2 ENSMUST00000128788.3 ENSMUST00000128788.4 ENSMUST00000128788.5 ENSMUST00000128788.6 ENSMUST00000128788.7 IFT20_MOUSE NM_018854 Q5SYG9 Q61025 Q99M35 uc007kjt.1 uc007kjt.2 uc007kjt.3 Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (PubMed:16775004). Regulates the ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling (PubMed:29237719). Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (PubMed:27682589). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (PubMed:24089209). Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (PubMed:12821668, PubMed:16775004, PubMed:19253336). Interacts directly with IFT57 and KIF3B/Kinesin II subunit (PubMed:12821668). Interacts with IFT88 (PubMed:19253336). Interacts with CEP83 (By similarity). Interacts with SPEF2 (via C-terminus) (PubMed:19889948). Interacts with CBL and CBLB (By similarity). Interacts with TRIP11 (PubMed:19112494). Interacts with TTC21A (By similarity). Interacts with SPATA1 (PubMed:31816150). Interacts with USH1G (By similarity). Q61025; Q8C0J2: Atg16l1; NbExp=2; IntAct=EBI-16077253, EBI-769195; Golgi apparatus, cis-Golgi network toplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body Cell projection, cilium toplasm, cytoskeleton lgi apparatus Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasm Note=Present at the centrosomes during the cell cycle and associated with the proximal portion of the mother centriole and the lateral aspect of the daughter centriole (PubMed:15337773). Associated with basal body at the base of primary cilia (PubMed:15337773). Detected in the Golgi apparatus of round spermatids and late spermatocytes (PubMed:19889948, PubMed:28619825). Also detected in the manchette of step 10-12 spermatids (PubMed:19889948, PubMed:28619825). In step 14 spermatids, found in the basal body of the sperm tail (PubMed:19889948). Localization in the manchette of elongating spermatids is dependent on SPAG17 (PubMed:29690537). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61025-1; Sequence=Displayed; Name=2; IsoId=Q61025-2; Sequence=VSP_020392; Expressed predominantly in the testis (at protein level). Expressed in kidney and retina. Expression is up-regulated during spermiogenesis. Expression is first detected at postnatal day 16 (P16) and increases significantly at days P30 and P42. Conditional knockout in male germ cells results in infertility, abnormal sperm morphology, significantly reduced sperm count and sperm mobility. Cells that stably express short interference RNAs targeting IFT20 show reduced centriolar IFT20 and lack primary cilia. Sequence=CAI25553.1; Type=Erroneous gene model prediction; Evidence=; establishment of planar polarity photoreceptor outer segment kidney development opsin binding protein binding cytoplasm Golgi apparatus cis-Golgi network centrosome centriole cytoskeleton microvillus cilium smoothened signaling pathway spermatogenesis visual learning Rab GTPase binding neurogenesis cell projection organization cell differentiation intraciliary transport particle B motile cilium photoreceptor connecting cilium stereocilium protein localization to Golgi apparatus photoreceptor cell outer segment organization ciliary basal body opsin transport intraciliary transport cell projection dendrite terminus centrosome localization cardiac muscle cell differentiation inner ear receptor stereocilium organization cilium assembly regulation of canonical Wnt signaling pathway neural precursor cell proliferation protein localization to cilium protein localization to plasma membrane cochlea development ciliary base regulation of cilium assembly kinociliary basal body regulation of platelet-derived growth factor receptor-alpha signaling pathway regulation of autophagosome assembly uc007kjt.1 uc007kjt.2 uc007kjt.3 
ENSMUST00000128807.2 Gm16145 ENSMUST00000128807.2 Gm16145 (from geneSymbol) ENSMUST00000128807.1 uc287rtp.1 uc287rtp.2 uc287rtp.1 uc287rtp.2 
ENSMUST00000128832.3 Gm15555 ENSMUST00000128832.3 predicted gene 15555 (from RefSeq NR_155447.1) ENSMUST00000128832.1 ENSMUST00000128832.2 NR_155447 uc007zrv.1 uc007zrv.2 uc007zrv.1 uc007zrv.2 
ENSMUST00000128841.2 Gm16024 ENSMUST00000128841.2 Gm16024 (from geneSymbol) ENSMUST00000128841.1 uc290sly.1 uc290sly.2 uc290sly.1 uc290sly.2 
ENSMUST00000128846.2 Gm14255 ENSMUST00000128846.2 Gm14255 (from geneSymbol) ENSMUST00000128846.1 uc290cgz.1 uc290cgz.2 uc290cgz.1 uc290cgz.2 
ENSMUST00000128848.8 1810062O18Rik ENSMUST00000128848.8 1810062O18Rik (from geneSymbol) AK007938 ENSMUST00000128848.1 ENSMUST00000128848.2 ENSMUST00000128848.3 ENSMUST00000128848.4 ENSMUST00000128848.5 ENSMUST00000128848.6 ENSMUST00000128848.7 uc288rgs.1 uc288rgs.2 uc288rgs.1 uc288rgs.2 
ENSMUST00000128858.3 Gm14379 ENSMUST00000128858.3 predicted gene 14379 (from RefSeq NR_026741.1) ENSMUST00000128858.1 ENSMUST00000128858.2 NR_026741 uc009slf.1 uc009slf.2 uc009slf.3 uc009slf.4 uc009slf.1 uc009slf.2 uc009slf.3 uc009slf.4 
ENSMUST00000128859.2 Gm13618 ENSMUST00000128859.2 Gm13618 (from geneSymbol) ENSMUST00000128859.1 uc289wnk.1 uc289wnk.2 uc289wnk.1 uc289wnk.2 
ENSMUST00000128860.8 Cdh8 ENSMUST00000128860.8 cadherin 8, transcript variant 2 (from RefSeq NM_007667.3) CADH8_MOUSE ENSMUST00000128860.1 ENSMUST00000128860.2 ENSMUST00000128860.3 ENSMUST00000128860.4 ENSMUST00000128860.5 ENSMUST00000128860.6 ENSMUST00000128860.7 G3UVU4 NM_007667 P97291 uc009mzo.1 uc009mzo.2 uc009mzo.3 uc009mzo.4 This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein exhibit reduced behavioral responses to cold, but not thermal stimuli. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015]. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. P97291; P97291: Cdh8; NbExp=2; IntAct=EBI-15719457, EBI-15719457; Cell membrane; Single-pass type I membrane protein. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. cell morphogenesis calcium ion binding plasma membrane cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules chemical synaptic transmission cytoskeletal protein binding response to cold cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex adherens junction organization synaptic transmission, glutamatergic identical protein binding protein homodimerization activity synaptic cleft axon terminus cell-cell adhesion mediated by cadherin cadherin binding metal ion binding regulation of synapse organization synaptic membrane cell-cell adhesion glutamatergic synapse uc009mzo.1 uc009mzo.2 uc009mzo.3 uc009mzo.4 
ENSMUST00000128894.2 Gm15336 ENSMUST00000128894.2 Gm15336 (from geneSymbol) AK140850 ENSMUST00000128894.1 uc289oxq.1 uc289oxq.2 uc289oxq.1 uc289oxq.2 
ENSMUST00000128901.9 Edrf1 ENSMUST00000128901.9 erythroid differentiation regulatory factor 1, transcript variant 5 (from RefSeq NR_176447.1) 2700050L05Rik D3YZE7 D3YZE7_MOUSE ENSMUST00000128901.1 ENSMUST00000128901.2 ENSMUST00000128901.3 ENSMUST00000128901.4 ENSMUST00000128901.5 ENSMUST00000128901.6 ENSMUST00000128901.7 ENSMUST00000128901.8 Edrf1 NR_176447 uc291wlo.1 uc291wlo.2 uc291wlo.1 uc291wlo.2 
ENSMUST00000128914.4 Gm15912 ENSMUST00000128914.4 Gm15912 (from geneSymbol) ENSMUST00000128914.1 ENSMUST00000128914.2 ENSMUST00000128914.3 KY467675 uc288omz.1 uc288omz.2 uc288omz.3 uc288omz.4 uc288omz.1 uc288omz.2 uc288omz.3 uc288omz.4 
ENSMUST00000128925.2 4930556G01Rik ENSMUST00000128925.2 4930556G01Rik (from geneSymbol) ENSMUST00000128925.1 uc290loo.1 uc290loo.2 uc290loo.1 uc290loo.2 
ENSMUST00000128944.8 Gramd2a ENSMUST00000128944.8 GRAM domain containing 2A, transcript variant 1 (from RefSeq NM_001357686.1) B2RSP5 ENSMUST00000128944.1 ENSMUST00000128944.2 ENSMUST00000128944.3 ENSMUST00000128944.4 ENSMUST00000128944.5 ENSMUST00000128944.6 ENSMUST00000128944.7 GRM2A_MOUSE Gramd2 Gramd2a NM_001357686 Q3V3E4 Q3V3G7 uc009pyk.1 uc009pyk.2 uc009pyk.3 Participates in the organization ofendoplasmic reticulum- plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum- plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE). Endoplasmic reticulum membrane ; Single-pass membrane protein Cell membrane ; Peripheral membrane protein Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Anchored at the ER, PM binding is mediated via GRAM domain and phosphatidylinositol lipid interaction. Localizes to distinct EPCS than GRAMD1A. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3V3G7-1; Sequence=Displayed; Name=2; IsoId=Q3V3G7-2; Sequence=VSP_025478; GRAM domain is required for specific location to endoplasmic reticulum-plasma membrane contact sites (EPCS). Mediates interaction to phosphatidylinositol lipids and binding to plasma membrane. Phosphorylated. phosphatidylinositol-4,5-bisphosphate binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane lipid binding membrane integral component of membrane intrinsic component of endoplasmic reticulum membrane extrinsic component of cytoplasmic side of plasma membrane phosphatidylinositol binding organelle membrane contact site endoplasmic reticulum-plasma membrane tethering regulation of store-operated calcium entry uc009pyk.1 uc009pyk.2 uc009pyk.3 
ENSMUST00000128996.3 Gm12059 ENSMUST00000128996.3 Gm12059 (from geneSymbol) ENSMUST00000128996.1 ENSMUST00000128996.2 KY467573 uc057kkn.1 uc057kkn.2 uc057kkn.3 uc057kkn.1 uc057kkn.2 uc057kkn.3 
ENSMUST00000129000.2 Gm14978 ENSMUST00000129000.2 Gm14978 (from geneSymbol) ENSMUST00000129000.1 uc289zwy.1 uc289zwy.2 uc289zwy.1 uc289zwy.2 
ENSMUST00000129014.2 Serf1 ENSMUST00000129014.2 Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (By similarity). (from UniProt O88892) BC028510 ENSMUST00000129014.1 O88892 SERF1_MOUSE uc288pms.1 uc288pms.2 Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (By similarity). Interacts with SNCA; this interaction promotes the aggregation of SNCA. Cytoplasm, cytosol Nucleus Expressed in brain (at protein level) (PubMed:31034892). Highly expressed in the testis (PubMed:9731538). Belongs to the SERF family. molecular_function cellular_component biological_process uc288pms.1 uc288pms.2 
ENSMUST00000129046.9 Tcp11 ENSMUST00000129046.9 t-complex protein 11, transcript variant 7 (from RefSeq NM_001399995.1) B2KF24 B2KF24_MOUSE B2KF25 ENSMUST00000129046.1 ENSMUST00000129046.2 ENSMUST00000129046.3 ENSMUST00000129046.4 ENSMUST00000129046.5 ENSMUST00000129046.6 ENSMUST00000129046.7 ENSMUST00000129046.8 NM_001399995 Tcp11 uc289ivz.1 uc289ivz.2 Belongs to the TCP11 family. acrosomal vesicle sperm flagellum uc289ivz.1 uc289ivz.2 
ENSMUST00000129056.3 Or5d18 ENSMUST00000129056.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q920P2) ENSMUST00000129056.1 ENSMUST00000129056.2 Olfr73 Or5d18 Q920P2 Q920P2_MOUSE mOR-EG uc289xxi.1 uc289xxi.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxi.1 uc289xxi.2 
ENSMUST00000129058.2 Gm45591 ENSMUST00000129058.2 Gm45591 (from geneSymbol) ENSMUST00000129058.1 uc291syr.1 uc291syr.2 uc291syr.1 uc291syr.2 
ENSMUST00000129059.3 2610206C17Rik ENSMUST00000129059.3 RIKEN cDNA 2610206C17 gene (from RefSeq NR_038175.1) ENSMUST00000129059.1 ENSMUST00000129059.2 NR_038175 uc009ieo.1 uc009ieo.2 uc009ieo.1 uc009ieo.2 
ENSMUST00000129067.2 Gm14120 ENSMUST00000129067.2 Gm14120 (from geneSymbol) AK053252 ENSMUST00000129067.1 uc290bdw.1 uc290bdw.2 uc290bdw.1 uc290bdw.2 
ENSMUST00000129108.4 Tbx3os1 ENSMUST00000129108.4 T-box 3, opposite strand 1, transcript variant 1 (from RefSeq NR_172461.1) ENSMUST00000129108.1 ENSMUST00000129108.2 ENSMUST00000129108.3 NR_172461 uc290zau.1 uc290zau.2 uc290zau.3 uc290zau.4 uc290zau.1 uc290zau.2 uc290zau.3 uc290zau.4 
ENSMUST00000129114.3 Mettl5os ENSMUST00000129114.3 Mettl5os (from geneSymbol) AK016085 ENSMUST00000129114.1 ENSMUST00000129114.2 uc008jyx.1 uc008jyx.2 uc008jyx.3 uc008jyx.1 uc008jyx.2 uc008jyx.3 
ENSMUST00000129126.2 Gm12246 ENSMUST00000129126.2 Gm12246 (from geneSymbol) ENSMUST00000129126.1 KY467587 uc287yit.1 uc287yit.2 uc287yit.1 uc287yit.2 
ENSMUST00000129139.3 Gm11712 ENSMUST00000129139.3 Gm11712 (from geneSymbol) ENSMUST00000129139.1 ENSMUST00000129139.2 uc288dck.1 uc288dck.2 uc288dck.3 uc288dck.1 uc288dck.2 uc288dck.3 
ENSMUST00000129158.2 Gm16346 ENSMUST00000129158.2 Gm16346 (from geneSymbol) ENSMUST00000129158.1 uc291ymz.1 uc291ymz.2 uc291ymz.1 uc291ymz.2 
ENSMUST00000129162.3 Mmgt2 ENSMUST00000129162.3 Mediates Mg(2+) transport. (from UniProt Q8R3L0) AK004099 ENSMUST00000129162.1 ENSMUST00000129162.2 MMGT2_MOUSE Mmgt2 Q8R3L0 uc287yxi.1 uc287yxi.2 Mediates Mg(2+) transport. Golgi apparatus membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein High expression levels in brain and kidney with lower levels in heart, colon and liver. Very low levels in intestine. In kidney, highest levels in distal convoluted tubule. Up-regulated by low extracellular Mg(2+). Belongs to the membrane magnesium transporter (TC 1.A.67) family. Golgi membrane copper ion transmembrane transporter activity manganese ion transmembrane transporter activity endosome early endosome Golgi apparatus plasma membrane cation transport cobalt ion transport copper ion transport manganese ion transport cobalt ion transmembrane transporter activity magnesium ion transmembrane transporter activity nickel cation transmembrane transporter activity nickel cation transport magnesium ion transport membrane integral component of membrane inorganic cation transmembrane transporter activity early endosome membrane copper ion transmembrane transport nickel cation transmembrane transport manganese ion transmembrane transport ER membrane protein complex cation transmembrane transport magnesium ion transmembrane transport uc287yxi.1 uc287yxi.2 
ENSMUST00000129164.9 C030005K06Rik ENSMUST00000129164.9 C030005K06Rik (from geneSymbol) AK043286 ENSMUST00000129164.1 ENSMUST00000129164.2 ENSMUST00000129164.3 ENSMUST00000129164.4 ENSMUST00000129164.5 ENSMUST00000129164.6 ENSMUST00000129164.7 ENSMUST00000129164.8 uc008ewt.1 uc008ewt.2 uc008ewt.3 uc008ewt.1 uc008ewt.2 uc008ewt.3 
ENSMUST00000129261.2 Gm11534 ENSMUST00000129261.2 Gm11534 (from geneSymbol) ENSMUST00000129261.1 uc288bpw.1 uc288bpw.2 uc288bpw.1 uc288bpw.2 
ENSMUST00000129269.8 Stag1 ENSMUST00000129269.8 STAG1 cohesin complex component, transcript variant 1 (from RefSeq NM_009282.5) ENSMUST00000129269.1 ENSMUST00000129269.2 ENSMUST00000129269.3 ENSMUST00000129269.4 ENSMUST00000129269.5 ENSMUST00000129269.6 ENSMUST00000129269.7 NM_009282 O08982 Q6P5D1 Q9D3E6 STAG1_MOUSE Sa1 uc009rfa.1 uc009rfa.2 uc009rfa.3 Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG1 is mutually exclusive with STAG2 and STAG3. Interacts directly with RAD21 in cohesin complex. The cohesin complex interacts with the cohesin loading complex subunits NIPBL/Scc2 (via HEAT repeats) and MAU2/Scc4. NIPBL directly contacts all members of the complex, RAD21, SMC1A/B, SMC3 and STAG1 (By similarity). Nucleus Chromosome Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation (By similarity). Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity). Belongs to the SCC3 family. Sequence=BAB31022.1; Type=Miscellaneous discrepancy; Note=Probable exon deletions within the cDNA.; Evidence=; chromatin chromatin binding nucleus nucleoplasm chromosome cell cycle chromosome segregation sister chromatid cohesion cohesin complex nuclear matrix nuclear body cell division mitotic spindle pole regulation of mitotic spindle assembly uc009rfa.1 uc009rfa.2 uc009rfa.3 
ENSMUST00000129275.3 Usp46os1 ENSMUST00000129275.3 Usp46os1 (from geneSymbol) AK007057 ENSMUST00000129275.1 ENSMUST00000129275.2 uc290wjn.1 uc290wjn.2 uc290wjn.1 uc290wjn.2 
ENSMUST00000129308.9 Flad1 ENSMUST00000129308.9 Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. (from UniProt Q8R123) AK161929 ENSMUST00000129308.1 ENSMUST00000129308.2 ENSMUST00000129308.3 ENSMUST00000129308.4 ENSMUST00000129308.5 ENSMUST00000129308.6 ENSMUST00000129308.7 ENSMUST00000129308.8 FAD1_MOUSE Q3TSN6 Q8BXQ1 Q8R123 uc008pzi.1 uc008pzi.2 uc008pzi.3 Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Reaction=ATP + FMN + H(+) = diphosphate + FAD; Xref=Rhea:RHEA:17237, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57692, ChEBI:CHEBI:58210; EC=2.7.7.2; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R123-1; Sequence=Displayed; Name=2; IsoId=Q8R123-2; Sequence=VSP_027955; The molybdenum cofactor biosynthesis protein-like region may not be functional. In the N-terminal section; belongs to the MoaB/Mog family. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. nucleotide binding catalytic activity FMN adenylyltransferase activity ATP binding cytoplasm cytosol plasma membrane FAD biosynthetic process transferase activity nucleotidyltransferase activity uc008pzi.1 uc008pzi.2 uc008pzi.3 
ENSMUST00000129321.2 Rnf227 ENSMUST00000129321.2 ring finger protein 227 (from RefSeq NM_001413473.1) A0A140LI80 Chd3os ENSMUST00000129321.1 MNCb-2875 NM_001413473 Q9DCB3 Q9JJ82 RN227_MOUSE Rnf227 uc287zgm.1 uc287zgm.2 Sequence=BAA95115.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB22482.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; metal ion binding uc287zgm.1 uc287zgm.2 
ENSMUST00000129335.8 Numb ENSMUST00000129335.8 NUMB endocytic adaptor protein, transcript variant 7 (from RefSeq NM_001411949.1) ENSMUST00000129335.1 ENSMUST00000129335.2 ENSMUST00000129335.3 ENSMUST00000129335.4 ENSMUST00000129335.5 ENSMUST00000129335.6 ENSMUST00000129335.7 NM_001411949 NUMB_MOUSE P70422 Q8CIB1 Q9DC57 Q9QZR1 Q9QZS3 Q9QZS4 uc007odv.1 uc007odv.2 uc007odv.3 uc007odv.4 Regulates clathrin-mediated receptor endocytosis (By similarity). Plays a role in the process of neurogenesis (PubMed:10841580, PubMed:12410312, PubMed:15273690, PubMed:17174898). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (PubMed:15273690, PubMed:12410312). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis (PubMed:15273690, PubMed:12410312). Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (PubMed:17174898). May also mediate local repair of brain ventricular wall damage (PubMed:17174898). Interacts with SIAH1 (By similarity). Interacts with LNX (PubMed:9535908). Interacts with CDH1 (PubMed:17174898). Interacts with TFAP2A and TFAP2B (By similarity). Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis (By similarity). Interacts with AAK1 (By similarity). May interact with DUOXA1 (By similarity). Q9QZS3-1; P42566: EPS15; Xeno; NbExp=3; IntAct=EBI-9547433, EBI-396684; Q9QZS3-1; Q96D71: REPS1; Xeno; NbExp=3; IntAct=EBI-9547433, EBI-1171195; Q9QZS3-2; P42566: EPS15; Xeno; NbExp=3; IntAct=EBI-3896014, EBI-396684; Q9QZS3-2; P08151: GLI1; Xeno; NbExp=4; IntAct=EBI-3896014, EBI-308084; Q9QZS3-2; Q96J02: ITCH; Xeno; NbExp=2; IntAct=EBI-3896014, EBI-1564678; Q9QZS3-2; Q96D71: REPS1; Xeno; NbExp=2; IntAct=EBI-3896014, EBI-1171195; Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Localizes to perinuclear endosomes in an AAK1-dependent manner. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=p72, 72 kDa; IsoId=Q9QZS3-1; Sequence=Displayed; Name=2; Synonyms=p66, 66 kDa; IsoId=Q9QZS3-2; Sequence=VSP_004351; Name=3; Synonyms=p71, 71 kDa; IsoId=Q9QZS3-3; Sequence=VSP_004350; Name=4; Synonyms=p65, 65 kDa; IsoId=Q9QZS3-4; Sequence=VSP_004350, VSP_004351; Expressed in subventricular zone (SVZ) neuroprogenitors and ependymal cells. Expressed in neural progenitors and neuron cells throughout the developing nervous system. Expressed in somites and throughout the neural tube from 8.5 dpc, onward. Phosphorylated on Ser-276 and Ser-295 by CaMK1. Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (By similarity) Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation. Mutant animals exhibit severe defects in cranial neuronal tube closure and die around 11.5 dpc, but neurogenesis abnormalities are limited. Mice lacking both Numb and Numbl genes die around 9.5 dpc, with severe defects in somite and vasculature formation, neuronal tube closure and axial turning. Conditional mutants, with expression abrogated in neural progenitor cells from 8.5 dpc are viable, fertile and exhibit no obvious phenotypes. Conditional double-knockout (cdKO) mutants (Numb and Numbl genes), with expression abrogated in neural progenitor cells from 8.5 dpc (just before the onset of neurogenesis), display a loss of neuronal progenitor cells formation and an overexpression of neurons as neurogenesis progresses; cdKO mutants become necrotic at 12.5 dpc and die around this stage. Conditional double-knockout (cdKO) mutants (Numb and Numbl genes), with expression abrogated in neural progenitor cells from 10.5 dpc (just after the onset of neurogenesis), display a premature depletion of neural progenitor cells in the dorsal forebrain ventrical zone of the neocortex and in the hippocampal CA fields as neurogenesis progresses; cdKO mutants are viable and fertile, but showed a reduction in the thickness of the neocortex and the hippocampus and a enlargement of the lateral ventricles. Tamoxifen-inducible double-knockout (cdKO) mutants (Numb and Numbl genes), with expression abrogated postnatally in the subventricular zone (SVZ) neuroprogenitors and in ependymal cells, display a loss of SVZ neuroblasts and show a disorganized ependyma lacking both interdigitation junction between neighboring cells and increasing number of separated cells. protein binding nucleus cytoplasm early endosome plasma membrane multicellular organism development nervous system development neuroblast proliferation axonogenesis beta-catenin binding postsynaptic density membrane basolateral plasma membrane extrinsic component of plasma membrane lateral ventricle development neuroblast division in subventricular zone clathrin-coated vesicle positive regulation of cell migration forebrain development cytoplasmic vesicle adherens junction organization apical part of cell alpha-catenin binding cadherin binding regulation of neuron differentiation positive regulation of neurogenesis positive regulation of dendrite morphogenesis glutamatergic synapse negative regulation of protein localization to plasma membrane apical plasma membrane uc007odv.1 uc007odv.2 uc007odv.3 uc007odv.4 
ENSMUST00000129339.8 Eef1b2 ENSMUST00000129339.8 eukaryotic translation elongation factor 1 beta 2 (from RefSeq NM_018796.3) EF1B_MOUSE ENSMUST00000129339.1 ENSMUST00000129339.2 ENSMUST00000129339.3 ENSMUST00000129339.4 ENSMUST00000129339.5 ENSMUST00000129339.6 ENSMUST00000129339.7 Eef1b NM_018796 O70251 Q3THP5 Q5SUH1 Q8CHS1 Q99L22 Q9CZD4 uc007bfz.1 uc007bfz.2 uc007bfz.3 uc007bfz.4 EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma. Phosphorylation affects the GDP/GTP exchange rate. Belongs to the EF-1-beta/EF-1-delta family. Sequence=AAH39635.1; Type=Erroneous initiation; Evidence=; translation elongation factor activity guanyl-nucleotide exchange factor activity protein binding cytoplasm cytosol eukaryotic translation elongation factor 1 complex translation translational elongation response to ethanol endoplasmic reticulum uc007bfz.1 uc007bfz.2 uc007bfz.3 uc007bfz.4 
ENSMUST00000129407.3 Gm11467 ENSMUST00000129407.3 Gm11467 (from geneSymbol) ENSMUST00000129407.1 ENSMUST00000129407.2 uc290cpx.1 uc290cpx.2 uc290cpx.3 uc290cpx.1 uc290cpx.2 uc290cpx.3 
ENSMUST00000129408.2 Gm16178 ENSMUST00000129408.2 Gm16178 (from geneSymbol) ENSMUST00000129408.1 uc292adn.1 uc292adn.2 uc292adn.1 uc292adn.2 
ENSMUST00000129410.2 Gm15245 ENSMUST00000129410.2 predicted gene 15245 (from RefSeq NR_166846.1) ENSMUST00000129410.1 NR_166846 uc292ruk.1 uc292ruk.2 uc292ruk.1 uc292ruk.2 
ENSMUST00000129411.7 Gm45234 ENSMUST00000129411.7 Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of the poly-Q repeats (By similarity). Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. (from UniProt O35126) AK143504 ATN1_MOUSE Atn1 Drpla ENSMUST00000129411.1 ENSMUST00000129411.2 ENSMUST00000129411.3 ENSMUST00000129411.4 ENSMUST00000129411.5 ENSMUST00000129411.6 O35126 P70200 Q80YQ0 uc291iun.1 uc291iun.2 Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of the poly-Q repeats (By similarity). Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. Interacts with BAIAP2, WWP1, WWP2, WWP3 and RERE. Interacts (via its N-terminus) with MTG8; the interaction enhances transcriptional repression of MTG8. Interacts with PQBP1 (By similarity). Interacts with NR2E1; the interaction represses the transcriptional activity of NR2E1. Interacts with FAT1 (via a C- terminal domain). Cytoplasm, perinuclear region Cell junction Nucleus Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells. Colocalizes with MTG8 in discrete nuclear dots (By similarity). Widely expressed. Most abundant in the brain. Expressed as early as 5 days and thereafter shows little variation throughout 17 days. In vascular smooth muscle, induced by angiotensin II, FGF; PGF and IL1B. Phosphorylated in vitro by MAPK8/JNK1 on Ser-724. The poly-Gln region of Atn1 is polymorphic (3 to 8 repeats). The mouse model of DRPLA with 129 CAG repeats (Q129) exhibited severe neurological defects similar to those of juvenile- onset DRPLA patients including age-dependent and region-specific presynaptic dysfunction in the globus pallidus and cerebellum. Progressive shrinkage of distal dendrites of Purkinje cells and decreased currents through alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid and gamma-aminobutyrate type A receptors in CA1 neurons was observed. There is progressive brain atrophy. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding DNA binding transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm cytoplasm spermatogenesis determination of adult lifespan JUN kinase binding male gonad development toxin metabolic process pathogenesis post-embryonic development nuclear matrix cell migration protein domain specific binding maintenance of cell polarity cell junction cell leading edge response to food multicellular organism growth perinuclear region of cytoplasm neuron apoptotic process toxin activity positive regulation of nucleic acid-templated transcription uc291iun.1 uc291iun.2 
ENSMUST00000129414.9 Ubl5 ENSMUST00000129414.9 ubiquitin-like 5, transcript variant 2 (from RefSeq NM_025401.4) ENSMUST00000129414.1 ENSMUST00000129414.2 ENSMUST00000129414.3 ENSMUST00000129414.4 ENSMUST00000129414.5 ENSMUST00000129414.6 ENSMUST00000129414.7 ENSMUST00000129414.8 NM_025401 Q9EPV8 UBL5_MOUSE uc009ojc.1 uc009ojc.2 uc009ojc.3 Ubiquitin-like protein that plays a role in cell proliferation and sister chromatid cohesion by associating with spliceosomal proteins. Participates thereby in pre-mRNA splicing by maintaining spliceosome integrity. Promotes the functional integrity of the Fanconi anemia DNA repair pathway by interacting with FANCI component and subsequently mediating the formation of FANCI homodimers. Plays also a protective role against ER stress-induced apoptosis. Interacts with CLK1, CLK3 and CLK4. Interacts with coilin/COIL. Interacts with spliceosome components SART1 and EFTUD2. Interacts with FANCI; this interaction promotes FANCI dimerization. Cytoplasm Nucleus mRNA splicing, via spliceosome nucleus cytoplasm cellular protein modification process protein tag uc009ojc.1 uc009ojc.2 uc009ojc.3 
ENSMUST00000129421.8 Hal ENSMUST00000129421.8 histidine ammonia lyase (from RefSeq NM_010401.4) ENSMUST00000129421.1 ENSMUST00000129421.2 ENSMUST00000129421.3 ENSMUST00000129421.4 ENSMUST00000129421.5 ENSMUST00000129421.6 ENSMUST00000129421.7 HUTH_MOUSE Hsd Huth NM_010401 P35492 uc007gus.1 uc007gus.2 uc007gus.3 uc007gus.4 This gene encodes a member of the histidase protein family. The encoded protein is a cytosolic enzyme which catalyzes the first reaction in histidine catabolism. Defects in this protein cause histidinemia, which is characterized by increased histidine in blood, urine, and cerebrospinal fluid. [provided by RefSeq, Dec 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK014518.1, BC157999.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Reaction=L-histidine = NH4(+) + trans-urocanate; Xref=Rhea:RHEA:21232, ChEBI:CHEBI:17771, ChEBI:CHEBI:28938, ChEBI:CHEBI:57595; EC=4.3.1.3; Evidence=; Amino-acid degradation; L-histidine degradation into L- glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3. Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly. Note=Defects in Hal are the cause of histidinemia (His). Belongs to the PAL/histidase family. catalytic activity histidine ammonia-lyase activity cytoplasm histidine metabolic process histidine catabolic process lyase activity ammonia-lyase activity histidine catabolic process to glutamate and formamide histidine catabolic process to glutamate and formate uc007gus.1 uc007gus.2 uc007gus.3 uc007gus.4 
ENSMUST00000129423.8 Ttyh1 ENSMUST00000129423.8 Probable chloride channel. May be involved in cell adhesion (By similarity). (from UniProt Q9D3A9) AK018148 ENSMUST00000129423.1 ENSMUST00000129423.2 ENSMUST00000129423.3 ENSMUST00000129423.4 ENSMUST00000129423.5 ENSMUST00000129423.6 ENSMUST00000129423.7 Q6L751 Q6P0A7 Q8BRL4 Q8C7M4 Q9D3A9 Q9D5D1 Q9EQN7 Q9ESC3 TTYH1_MOUSE uc009ewx.1 uc009ewx.2 uc009ewx.3 uc009ewx.4 uc009ewx.5 Probable chloride channel. May be involved in cell adhesion (By similarity). Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D3A9-1; Sequence=Displayed; Name=4; IsoId=Q9D3A9-4; Sequence=VSP_029765; Name=5; IsoId=Q9D3A9-5; Sequence=VSP_029762, VSP_029763; Restricted mainly to neural tissues. Strongly expressed in brain and eye. Belongs to the tweety family. Sequence=AAG15842.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; [Isoform 4]: Sequence=BAD20188.1; Type=Frameshift; Evidence=; mitotic cell cycle intracellular calcium activated chloride channel activity chloride channel activity calcium ion binding plasma membrane ion transport chloride transport cell adhesion membrane integral component of membrane axon smooth endoplasmic reticulum membrane filopodium membrane cell-substrate adhesion filopodium tip ion transmembrane transport chloride channel complex synapse filopodium assembly volume-sensitive chloride channel activity cell-cell adhesion chloride transmembrane transport uc009ewx.1 uc009ewx.2 uc009ewx.3 uc009ewx.4 uc009ewx.5 
ENSMUST00000129441.8 Gm11491 ENSMUST00000129441.8 Gm11491 (from geneSymbol) AK040752 ENSMUST00000129441.1 ENSMUST00000129441.2 ENSMUST00000129441.3 ENSMUST00000129441.4 ENSMUST00000129441.5 ENSMUST00000129441.6 ENSMUST00000129441.7 uc007ktl.1 uc007ktl.2 uc007ktl.1 uc007ktl.2 
ENSMUST00000129449.3 Tmem170b ENSMUST00000129449.3 transmembrane protein 170B, transcript variant 1 (from RefSeq NM_001163572.2) ENSMUST00000129449.1 ENSMUST00000129449.2 NM_001163572 P86050 T170B_MOUSE Tmem170b uc011yyr.1 uc011yyr.2 uc011yyr.3 Interacts with CTNNB1. Cell membrane ; Multi-pass membrane protein Belongs to the TMEM170 family. molecular_function plasma membrane membrane integral component of membrane negative regulation of canonical Wnt signaling pathway uc011yyr.1 uc011yyr.2 uc011yyr.3 
ENSMUST00000129456.8 Fbxo30 ENSMUST00000129456.8 F-box protein 30, transcript variant 1 (from RefSeq NM_027968.3) ENSMUST00000129456.1 ENSMUST00000129456.2 ENSMUST00000129456.3 ENSMUST00000129456.4 ENSMUST00000129456.5 ENSMUST00000129456.6 ENSMUST00000129456.7 FBX30_MOUSE NM_027968 Q3UXU4 Q8BJL1 Q8CI21 Q9D9X5 uc007ejt.1 uc007ejt.2 uc007ejt.3 uc007ejt.4 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. Protein modification; protein ubiquitination. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1, CUL1 and RBX1/ROC1. Up-regulated in denervated muscles (at protein level), with highest expression levels around 14 days following denervation. Negatively regulated by the bone morphogenetic protein (BMP) pathway. Auto-ubiquitinated. May be neddylated. Neddylation may be required for E3 ligase activity, since it was observed only after purification with o- phenanthroline (PubMed:24076600). Sequence=AAH37691.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cellular_component biological_process zinc ion binding protein ubiquitination metal ion binding ubiquitin protein ligase activity uc007ejt.1 uc007ejt.2 uc007ejt.3 uc007ejt.4 
ENSMUST00000129460.2 Gm12705 ENSMUST00000129460.2 Gm12705 (from geneSymbol) ENSMUST00000129460.1 uc290nzr.1 uc290nzr.2 uc290nzr.1 uc290nzr.2 
ENSMUST00000129470.2 Gm16135 ENSMUST00000129470.2 Gm16135 (from geneSymbol) ENSMUST00000129470.1 KY467547 uc287rsj.1 uc287rsj.2 uc287rsj.1 uc287rsj.2 
ENSMUST00000129485.2 Gm15949 ENSMUST00000129485.2 Gm15949 (from geneSymbol) ENSMUST00000129485.1 uc290wbc.1 uc290wbc.2 uc290wbc.1 uc290wbc.2 
ENSMUST00000129501.2 Gm11715 ENSMUST00000129501.2 predicted gene 11715 (from RefSeq NR_169178.1) ENSMUST00000129501.1 NR_169178 uc057bal.1 uc057bal.2 uc057bal.3 uc057bal.1 uc057bal.2 uc057bal.3 
ENSMUST00000129507.5 Fam83e ENSMUST00000129507.5 family with sequence similarity 83, member E (from RefSeq NM_001033170.4) B9EIA0 ENSMUST00000129507.1 ENSMUST00000129507.2 ENSMUST00000129507.3 ENSMUST00000129507.4 FA83E_MOUSE Fam83e NM_001033170 Q3UN25 Q80XS7 uc009gwy.1 uc009gwy.2 uc009gwy.3 May play a role in MAPK signaling. May interact with RAF1. Belongs to the FAM83 family. Sequence=AAI39285.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=BAE25923.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; cellular_component biological_process protein kinase binding uc009gwy.1 uc009gwy.2 uc009gwy.3 
ENSMUST00000129513.2 Gm15457 ENSMUST00000129513.2 Gm15457 (from geneSymbol) AK030081 ENSMUST00000129513.1 uc287hlv.1 uc287hlv.2 uc287hlv.1 uc287hlv.2 
ENSMUST00000129527.8 Gm12606 ENSMUST00000129527.8 Gm12606 (from geneSymbol) AF032968 ENSMUST00000129527.1 ENSMUST00000129527.2 ENSMUST00000129527.3 ENSMUST00000129527.4 ENSMUST00000129527.5 ENSMUST00000129527.6 ENSMUST00000129527.7 uc008tog.1 uc008tog.2 uc008tog.3 uc008tog.1 uc008tog.2 uc008tog.3 
ENSMUST00000129546.4 Hotairm1 ENSMUST00000129546.4 Hoxa transcript antisense RNA, myeloid-specific 2 (from RefSeq NR_146400.1) ENSMUST00000129546.1 ENSMUST00000129546.2 ENSMUST00000129546.3 NR_146400 uc057bxd.1 uc057bxd.2 uc057bxd.3 uc057bxd.1 uc057bxd.2 uc057bxd.3 
ENSMUST00000129559.2 Gm15701 ENSMUST00000129559.2 Gm15701 (from geneSymbol) ENSMUST00000129559.1 uc291arl.1 uc291arl.2 uc291arl.1 uc291arl.2 
ENSMUST00000129574.3 Prrt1b ENSMUST00000129574.3 proline rich transmembrane protein 1B, transcript variant 1 (from RefSeq NM_001370923.1) A0A140LJJ2 A0A140LJJ2_MOUSE ENSMUST00000129574.1 ENSMUST00000129574.2 Gm13420 NM_001370923 Prrt1b uc289uni.1 uc289uni.2 Belongs to the CD225/Dispanin family. membrane integral component of membrane uc289uni.1 uc289uni.2 
ENSMUST00000129576.2 Gm12480 ENSMUST00000129576.2 Gm12480 (from geneSymbol) ENSMUST00000129576.1 uc290mun.1 uc290mun.2 uc290mun.1 uc290mun.2 
ENSMUST00000129584.2 4930517E11Rik ENSMUST00000129584.2 RIKEN cDNA 4930517E11 gene (from RefSeq NR_040611.1) ENSMUST00000129584.1 NR_040611 uc029uel.1 uc029uel.2 uc029uel.1 uc029uel.2 
ENSMUST00000129617.3 Gm12786 ENSMUST00000129617.3 Gm12786 (from geneSymbol) ENSMUST00000129617.1 ENSMUST00000129617.2 uc290ohs.1 uc290ohs.2 uc290ohs.3 uc290ohs.1 uc290ohs.2 uc290ohs.3 
ENSMUST00000129635.8 Lpin2 ENSMUST00000129635.8 lipin 2, transcript variant 2 (from RefSeq NM_022882.4) ENSMUST00000129635.1 ENSMUST00000129635.2 ENSMUST00000129635.3 ENSMUST00000129635.4 ENSMUST00000129635.5 ENSMUST00000129635.6 ENSMUST00000129635.7 LPIN2_MOUSE Lpin2 NM_022882 Q8C357 Q8C7I8 Q8CC85 Q8CHR7 Q99PI5 uc012awp.1 uc012awp.2 uc012awp.3 Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane (PubMed:17158099). Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn- glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27430; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Inhibited by N-ethylmaleimide. Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane. Note=Translocates from cytosol to endoplasmic reticulum membrane with increasing levels of oleate. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99PI5-1; Sequence=Displayed; Name=2; IsoId=Q99PI5-2; Sequence=VSP_010387, VSP_010388; Expressed at high level in liver and to some extend in lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon. Expressed also in circulating red blood cells and site of lymphopoiesis. By fasting in hepatocytes. Up-regulated in fld/fld (defect in LPIN1) mice. Up-regulated at protein level but not at transcript level in ob/ob and db/db mice, two obese mice models. Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity. Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif. Belongs to the lipin family. transcription coactivator activity nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol lipid metabolic process fatty acid metabolic process phosphatidate phosphatase activity fatty acid catabolic process membrane dephosphorylation hydrolase activity triglyceride biosynthetic process cellular response to insulin stimulus positive regulation of transcription from RNA polymerase II promoter uc012awp.1 uc012awp.2 uc012awp.3 
ENSMUST00000129643.9 A630010A05Rik ENSMUST00000129643.9 RIKEN cDNA A630010A05 gene (from RefSeq NR_033556.1) ENSMUST00000129643.1 ENSMUST00000129643.2 ENSMUST00000129643.3 ENSMUST00000129643.4 ENSMUST00000129643.5 ENSMUST00000129643.6 ENSMUST00000129643.7 ENSMUST00000129643.8 NR_033556 uc012abk.1 uc012abk.2 uc012abk.3 uc012abk.1 uc012abk.2 uc012abk.3 
ENSMUST00000129653.3 Glrx2 ENSMUST00000129653.3 glutaredoxin 2, transcript variant 4 (from RefSeq NM_001038594.1) ENSMUST00000129653.1 ENSMUST00000129653.2 GLRX2_MOUSE Grx2 NM_001038594 Q923X4 Q9DAG8 Q9JHY6 uc007cxc.1 uc007cxc.2 uc007cxc.3 Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. The 2Fe-2S present in the homodimer leads to inactivation of the enzyme. The 2Fe-2S may serve as a redox sensor: the presence of one-electron oxidants or reductants leading to the loss of the 2Fe-2S cluster, subsequent monomerization and activation of the enzyme (By similarity). Kinetic parameters: KM=1.68 mM for HEDS ; KM=1.77 mM for S-sulfocysteine ; KM=0.3 mM for L-cystine ; Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster (By similarity). [Isoform 1]: Mitochondrion. [Isoform 2]: Nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Grx2a; IsoId=Q923X4-1; Sequence=Displayed; Name=2; IsoId=Q923X4-2; Sequence=VSP_015222; Widely expressed. Highly expressed in testis, and at much lower level in kidney and brain. During development, it is expressed at highest level at 11 dpc. Belongs to the glutaredoxin family. Sequence=AAF86465.1; Type=Frameshift; Evidence=; nucleus nucleoplasm mitochondrion mitochondrial matrix electron carrier activity response to organic substance protein disulfide oxidoreductase activity electron transport chain dendrite response to hydrogen peroxide neuronal cell body intracellular membrane-bounded organelle cell redox homeostasis metal ion binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding oxidation-reduction process uc007cxc.1 uc007cxc.2 uc007cxc.3 
ENSMUST00000129662.3 Prickle3 ENSMUST00000129662.3 Belongs to the prickle / espinas / testin family. (from UniProt Q8BNH2) AK083704 ENSMUST00000129662.1 ENSMUST00000129662.2 Lmo6 Prickle3 Q8BNH2 Q8BNH2_MOUSE uc009slv.1 uc009slv.2 Belongs to the prickle / espinas / testin family. zinc ion binding metal ion binding uc009slv.1 uc009slv.2 
ENSMUST00000129680.8 Ramp2 ENSMUST00000129680.8 receptor (calcitonin) activity modifying protein 2 (from RefSeq NM_019444.2) ENSMUST00000129680.1 ENSMUST00000129680.2 ENSMUST00000129680.3 ENSMUST00000129680.4 ENSMUST00000129680.5 ENSMUST00000129680.6 ENSMUST00000129680.7 NM_019444 Q6IS25 Q9WUP0 RAMP2_MOUSE uc007lny.1 uc007lny.2 uc007lny.3 Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Heterodimer of CALCRL and RAMP2. Membrane ; Single-pass type I membrane protein Ubiquitous. Expressed predominantly in embryonic brain, lung and gut and in adult heart, lung, skeletal muscle and brain. Belongs to the RAMP family. angiogenesis vasculogenesis adrenomedullin receptor activity response to hypoxia sprouting angiogenesis cell cytoplasm plasma membrane calcium ion transport intracellular protein transport G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway heart development female pregnancy regulation of blood pressure regulation of G-protein coupled receptor protein signaling pathway cell surface positive regulation of gene expression coreceptor activity protein transport membrane integral component of membrane receptor internalization response to estradiol response to progesterone cellular response to hormone stimulus adherens junction assembly cellular response to vascular endothelial growth factor stimulus negative regulation of vascular permeability receptor complex positive regulation of angiogenesis bicellular tight junction assembly basement membrane assembly protein localization to plasma membrane vascular smooth muscle cell development amylin receptor activity amylin receptor signaling pathway adrenomedullin receptor complex adrenomedullin binding adrenomedullin receptor signaling pathway negative regulation of endothelial cell apoptotic process positive regulation of vasculogenesis uc007lny.1 uc007lny.2 uc007lny.3 
ENSMUST00000129685.8 Gm28042 ENSMUST00000129685.8 Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence=; (from UniProt B7ZCM9) B7ZCM9 B7ZCM9_MOUSE BC098210 ENSMUST00000129685.1 ENSMUST00000129685.2 ENSMUST00000129685.3 ENSMUST00000129685.4 ENSMUST00000129685.5 ENSMUST00000129685.6 ENSMUST00000129685.7 Gm28042 uc289zqz.1 uc289zqz.2 Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Cytoplasm, cytosol The N-terminal C2 domain associates with lipid membranes upon calcium binding. phospholipase activity phospholipase A2 activity calcium ion binding calcium-dependent phospholipid binding cytoplasm cytosol lipid metabolic process phospholipid catabolic process lipid catabolic process hydrolase activity glycerophospholipid catabolic process metal ion binding calcium-dependent phospholipase A2 activity uc289zqz.1 uc289zqz.2 
ENSMUST00000129696.2 Gm16151 ENSMUST00000129696.2 Gm16151 (from geneSymbol) ENSMUST00000129696.1 uc287hmz.1 uc287hmz.2 uc287hmz.1 uc287hmz.2 
ENSMUST00000129701.2 Gm15976 ENSMUST00000129701.2 Gm15976 (from geneSymbol) ENSMUST00000129701.1 uc289gdp.1 uc289gdp.2 uc289gdp.1 uc289gdp.2 
ENSMUST00000129723.2 Grin1os ENSMUST00000129723.2 glutamate receptor, ionotropic, NMDA1 (zeta 1), opposite strand (from RefSeq NR_168905.1) ENSMUST00000129723.1 NR_168905 uc289tvr.1 uc289tvr.2 uc289tvr.1 uc289tvr.2 
ENSMUST00000129749.9 Cd59b ENSMUST00000129749.9 Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity). (from UniProt P58019) BC139203 CD59B_MOUSE ENSMUST00000129749.1 ENSMUST00000129749.2 ENSMUST00000129749.3 ENSMUST00000129749.4 ENSMUST00000129749.5 ENSMUST00000129749.6 ENSMUST00000129749.7 ENSMUST00000129749.8 P58019 Q920G7 uc289yxo.1 uc289yxo.2 uc289yxo.3 Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity). Cell membrane; Lipid-anchor, GPI-anchor. Widely expressed in the kidneys, brain, lungs, spleen and testis (PubMed:11471050) Testis specific (PubMed:10946279). complement binding negative regulation of activation of membrane attack complex extracellular space plasma membrane cell surface membrane anchored component of membrane anchored component of external side of plasma membrane positive regulation of T cell proliferation sarcolemma negative regulation of apoptotic process compact myelin negative regulation of complement activation negative regulation of complement-dependent cytotoxicity uc289yxo.1 uc289yxo.2 uc289yxo.3 
ENSMUST00000129757.9 Odam ENSMUST00000129757.9 odontogenic, ameloblast asssociated (from RefSeq NM_027128.3) A1E960 Apin ENSMUST00000129757.1 ENSMUST00000129757.2 ENSMUST00000129757.3 ENSMUST00000129757.4 ENSMUST00000129757.5 ENSMUST00000129757.6 ENSMUST00000129757.7 ENSMUST00000129757.8 NM_027128 ODAM_MOUSE Q9D7E6 uc008xze.1 uc008xze.2 uc008xze.3 Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. Interacts (via C-terminus) with ARHGEF5. Secreted Cytoplasm Nucleus Highly expressed in tooth-associated epithelia. Predominantly expressed in mandible. O-glycosylated. Belongs to the ODAM family. Sequence=AAI32395.1; Type=Erroneous initiation; Evidence=; Sequence=AAI32397.1; Type=Erroneous initiation; Evidence=; Sequence=BAB26200.1; Type=Erroneous initiation; Evidence=; positive regulation of protein phosphorylation molecular_function extracellular region extracellular space nucleus cytoplasm inflammatory response response to wounding positive regulation of gene expression biomineral tissue development regulation of actin cytoskeleton organization odontogenesis of dentin-containing tooth positive regulation of GTPase activity positive regulation of epithelial cell proliferation involved in wound healing cell periphery supramolecular fiber uc008xze.1 uc008xze.2 uc008xze.3 
ENSMUST00000129758.3 Smim27 ENSMUST00000129758.3 small integral membrane protein 27 (from RefSeq NM_001349093.1) A0A140LHV9 ENSMUST00000129758.1 ENSMUST00000129758.2 NM_001349093 SIM27_MOUSE Smim27 Toporsos uc029uqa.1 uc029uqa.2 uc029uqa.3 uc029uqa.4 uc029uqa.5 Membrane ; Single-pass membrane protein membrane integral component of membrane uc029uqa.1 uc029uqa.2 uc029uqa.3 uc029uqa.4 uc029uqa.5 
ENSMUST00000129764.10 Mir503hg ENSMUST00000129764.10 Mir503hg (from geneSymbol) AK021262 ENSMUST00000129764.1 ENSMUST00000129764.2 ENSMUST00000129764.3 ENSMUST00000129764.4 ENSMUST00000129764.5 ENSMUST00000129764.6 ENSMUST00000129764.7 ENSMUST00000129764.8 ENSMUST00000129764.9 uc029xjy.1 uc029xjy.2 uc029xjy.3 uc029xjy.4 uc029xjy.5 uc029xjy.1 uc029xjy.2 uc029xjy.3 uc029xjy.4 uc029xjy.5 
ENSMUST00000129769.9 4933416I08Rik ENSMUST00000129769.9 RIKEN cDNA 4933416I08 gene (from RefSeq NM_027700.1) 4933416I08Rik A2CFG5 ENSMUST00000129769.1 ENSMUST00000129769.2 ENSMUST00000129769.3 ENSMUST00000129769.4 ENSMUST00000129769.5 ENSMUST00000129769.6 ENSMUST00000129769.7 ENSMUST00000129769.8 NM_027700 Q9D434 Q9D434_MOUSE uc292oeb.1 uc292oeb.2 uc292oeb.1 uc292oeb.2 
ENSMUST00000129773.2 Fam187b ENSMUST00000129773.2 family with sequence similarity 187, member B, transcript variant 3 (from RefSeq NM_001377036.1) ENSMUST00000129773.1 F187B_MOUSE NM_001377036 Q0VAY3 Q3UFH7 Tmem162 uc291ocg.1 uc291ocg.2 Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0VAY3-1; Sequence=Displayed; Name=2; IsoId=Q0VAY3-2; Sequence=VSP_024580; Belongs to the FAM187 family. molecular_function cellular_component biological_process membrane integral component of membrane uc291ocg.1 uc291ocg.2 
ENSMUST00000129780.3 C130046K22Rik ENSMUST00000129780.3 RIKEN cDNA C130046K22 gene, transcript variant 2 (from RefSeq NR_102389.1) ENSMUST00000129780.1 ENSMUST00000129780.2 NR_102389 uc033gav.1 uc033gav.2 uc033gav.3 uc033gav.4 uc033gav.1 uc033gav.2 uc033gav.3 uc033gav.4 
ENSMUST00000129820.8 Lsm11 ENSMUST00000129820.8 U7 snRNP-specific Sm-like protein LSM11 (from RefSeq NM_028185.2) ENSMUST00000129820.1 ENSMUST00000129820.2 ENSMUST00000129820.3 ENSMUST00000129820.4 ENSMUST00000129820.5 ENSMUST00000129820.6 ENSMUST00000129820.7 LSM11_MOUSE Lsm11 NM_028185 Q8BUV6 uc007ins.1 uc007ins.2 Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed:12975319, PubMed:15824063). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed:12975319, PubMed:15824063). Required for cell cycle progression from G1 to S phases (PubMed:16914750). Binds specifically to the Sm-binding site of U7 snRNA. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA (PubMed:12975319). Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins (PubMed:12975319). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (PubMed:19470752). Interacts (via the Sm domains) with CLNS1A (PubMed:16087681). Interacts with PRMT5, SMN, ZNF473 and WDR77 (PubMed:12975319, PubMed:16087681, PubMed:15824063). Nucleus The C-terminal SM 1 domain is both necessary for the binding to the Sm-binding site of U7 snRNA and U7 snRNP assembly (PubMed:12975319). The N-terminal domain is essential for histone pre- mRNA cleavage (PubMed:12975319). Amino acids 63-82 are sufficient to interact with ZNF473 (PubMed:12975319). Not methylated. Belongs to the snRNP Sm proteins family. RNA binding protein binding nucleus U7 snRNP telomerase holoenzyme complex mRNA processing mRNA 3'-end processing by stem-loop binding and cleavage nuclear body histone pre-mRNA 3'end processing complex U7 snRNA binding positive regulation of G1/S transition of mitotic cell cycle uc007ins.1 uc007ins.2 
ENSMUST00000129924.3 Kdm6bos ENSMUST00000129924.3 Kdm6bos (from geneSymbol) AK006879 ENSMUST00000129924.1 ENSMUST00000129924.2 uc287zhb.1 uc287zhb.2 uc287zhb.3 uc287zhb.1 uc287zhb.2 uc287zhb.3 
ENSMUST00000129933.2 Gm15199 ENSMUST00000129933.2 Gm15199 (from geneSymbol) AK035573 ENSMUST00000129933.1 uc007eyw.1 uc007eyw.2 uc007eyw.1 uc007eyw.2 
ENSMUST00000129948.9 Clec5a ENSMUST00000129948.9 C-type lectin domain family 5, member a, transcript variant 1 (from RefSeq NM_001038604.1) CLC5A_MOUSE Clecsf5 ENSMUST00000129948.1 ENSMUST00000129948.2 ENSMUST00000129948.3 ENSMUST00000129948.4 ENSMUST00000129948.5 ENSMUST00000129948.6 ENSMUST00000129948.7 ENSMUST00000129948.8 Mdl1 NM_001038604 Q3SXC9 Q3UV97 Q8BL24 Q9R007 uc009bna.1 uc009bna.2 uc009bna.3 Functions as a positive regulator of osteoclastogenesis (PubMed:19251634). Cell surface receptor that signals via TYROBP (PubMed:10449773). Regulates inflammatory responses (PubMed:20212065). Monomer (By similarity). Homodimer (By similarity). The majority of CLEC5A is expressed as a monomeric form on macrophages (By similarity). Interacts with TYROBP/DAP12 (PubMed:10449773). The interaction with TYROBP is required for CLEC5 cell surface expression (PubMed:10449773). Interacts with HCST/DAP10 (PubMed:19074552, PubMed:19251634). Forms a CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP (PubMed:19251634). Q9R007; Q9QUJ0: Hcst; NbExp=3; IntAct=EBI-15761206, EBI-15761243; Q9R007; O54885: Tyrobp; NbExp=3; IntAct=EBI-15761206, EBI-15687058; Cell membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q9R007-3; Sequence=Displayed; Name=1; IsoId=Q9R007-1; Sequence=VSP_041577; Name=2; IsoId=Q9R007-2; Sequence=VSP_012840; Strong expression in bone marrow cells and thioglycollate-induced neutrophils (at protein level) (PubMed:19074552). Expressed on granulocytes and monocytes from bone marrow and peripheral blood (PubMed:20212065). Expressed in macrophage cell line J-774, but not in T-cell lines, B-cell lines, or mast cell lines (PubMed:10449773). By TNF in bone-marrow derived macrophage colony-stimulating factor-dependent macrophages (PubMed:20212065). Up-regulated during the differentiation of myeloid cell line 32Dcl3 into neutrophils (PubMed:19074552). N-glycosylated (PubMed:19074552, PubMed:19251634). Contains sialic acid residues (PubMed:19074552). Note=Involved in the pathogenetic mechanisms of Japanese encephalitis virus (JEV) infection of the brain. JEV infection of young mice results in increased expression of CLEC5A in spleen and brain with consequent activation of proinflammatory cytokine secretion. Mutants are viable, are born in the expected Mendelian ratios and have similar numbers of myeloid and lymphoid cell subsets as wild-type animals (PubMed:20212065). Inhibition of autoimmune joint inflammation and preservation of bone density (PubMed:20212065). Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation when its activation leads to enhanced recruitment of inflammatory macrophages and neutrophils to the joints. Name=Functional Glycomics Gateway - Glycan Binding; Note=MDL-1; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_177"; virus receptor activity osteoblast development immune system process protein binding cytosol plasma membrane cell surface membrane integral component of membrane myeloid cell differentiation carbohydrate binding negative regulation of myeloid cell apoptotic process negative regulation of apoptotic process innate immune response viral entry into host cell positive regulation of cytokine secretion uc009bna.1 uc009bna.2 uc009bna.3 
ENSMUST00000129963.8 Gm2165 ENSMUST00000129963.8 Gm2165 (from geneSymbol) AK139882 ENSMUST00000129963.1 ENSMUST00000129963.2 ENSMUST00000129963.3 ENSMUST00000129963.4 ENSMUST00000129963.5 ENSMUST00000129963.6 ENSMUST00000129963.7 uc009swc.1 uc009swc.2 uc009swc.1 uc009swc.2 
ENSMUST00000129983.3 ENSMUSG00000121781 ENSMUST00000129983.3 ENSMUSG00000121781 (from geneSymbol) AK146160 ENSMUST00000129983.1 ENSMUST00000129983.2 uc292jao.1 uc292jao.2 uc292jao.3 uc292jao.1 uc292jao.2 uc292jao.3 
ENSMUST00000129990.9 Cfap46 ENSMUST00000129990.9 cilia and flagella associated protein 46 (from RefSeq NM_001302546.1) Cfap46 E9Q2C0 E9Q2C0_MOUSE ENSMUST00000129990.1 ENSMUST00000129990.2 ENSMUST00000129990.3 ENSMUST00000129990.4 ENSMUST00000129990.5 ENSMUST00000129990.6 ENSMUST00000129990.7 ENSMUST00000129990.8 NM_001302546 uc057lvp.1 uc057lvp.2 uc057lvp.3 molecular_function axoneme assembly cilium movement involved in cell motility uc057lvp.1 uc057lvp.2 uc057lvp.3 
ENSMUST00000129994.8 Gm13335 ENSMUST00000129994.8 Gm13335 (from geneSymbol) ENSMUST00000129994.1 ENSMUST00000129994.2 ENSMUST00000129994.3 ENSMUST00000129994.4 ENSMUST00000129994.5 ENSMUST00000129994.6 ENSMUST00000129994.7 KY467836 uc289tla.1 uc289tla.2 uc289tla.1 uc289tla.2 
ENSMUST00000130048.8 Vegfb ENSMUST00000130048.8 vascular endothelial growth factor B, transcript variant 2 (from RefSeq NM_001185164.1) ENSMUST00000130048.1 ENSMUST00000130048.2 ENSMUST00000130048.3 ENSMUST00000130048.4 ENSMUST00000130048.5 ENSMUST00000130048.6 ENSMUST00000130048.7 NM_001185164 P49766 Q3UG04 Q5D0B1 Q64290 VEGFB_MOUSE Vrf uc008gjw.1 uc008gjw.2 uc008gjw.3 uc008gjw.4 Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. VEGF-B seems to be required for normal heart function in adult but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults. Homodimer; disulfide-linked. Can also form heterodimer with VEGF. Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin. Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=VEGF-B186; IsoId=P49766-1; Sequence=Displayed; Name=VEGF-B167; IsoId=P49766-2; Sequence=VSP_004641; Abundantly expressed in heart, brain, kidney and skeletal muscle. VEGF-B186 is O-glycosylated. Belongs to the PDGF/VEGF growth factor family. angiogenesis response to hypoxia positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation sprouting angiogenesis vascular endothelial growth factor receptor binding extracellular region extracellular space protein O-linked glycosylation multicellular organism development heart development growth factor activity heparin binding negative regulation of gene expression membrane cell differentiation positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of vascular wound healing vascular endothelial growth factor signaling pathway chemoattractant activity protein homodimerization activity negative regulation of apoptotic process vascular endothelial growth factor receptor 1 binding negative regulation of neuron apoptotic process positive regulation of angiogenesis protein heterodimerization activity vascular endothelial growth factor receptor signaling pathway positive regulation of peptidyl-tyrosine phosphorylation positive chemotaxis induction of positive chemotaxis positive regulation of cell division positive regulation of protein kinase B signaling cardiac muscle contraction positive regulation of mast cell chemotaxis coronary vasculature development positive regulation of ERK1 and ERK2 cascade uc008gjw.1 uc008gjw.2 uc008gjw.3 uc008gjw.4 
ENSMUST00000130054.2 B430119L08Rik ENSMUST00000130054.2 B430119L08Rik (from geneSymbol) AK046594 ENSMUST00000130054.1 uc288iwl.1 uc288iwl.2 uc288iwl.1 uc288iwl.2 
ENSMUST00000130083.4 Gm35202 ENSMUST00000130083.4 Gm35202 (from geneSymbol) ENSMUST00000130083.1 ENSMUST00000130083.2 ENSMUST00000130083.3 uc289vmz.1 uc289vmz.2 uc289vmz.3 uc289vmz.1 uc289vmz.2 uc289vmz.3 
ENSMUST00000130092.2 Gm12665 ENSMUST00000130092.2 Gm12665 (from geneSymbol) ENSMUST00000130092.1 uc287xaz.1 uc287xaz.2 uc287xaz.1 uc287xaz.2 
ENSMUST00000130158.8 Nrg4 ENSMUST00000130158.8 Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. (from UniProt Q9WTX4) AF083067 ENSMUST00000130158.1 ENSMUST00000130158.2 ENSMUST00000130158.3 ENSMUST00000130158.4 ENSMUST00000130158.5 ENSMUST00000130158.6 ENSMUST00000130158.7 NRG4_MOUSE Q9WTX4 uc292hjw.1 uc292hjw.2 Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Interacts with ERBB4. [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane ; Single-pass type I membrane protein Note=Does not seem to be active. [Neuregulin-4]: Secreted Event=Alternative splicing; Named isoforms=1; Comment=At least 3 isoforms may be produced.; Name=1; IsoId=Q9WTX4-1; Sequence=Displayed; Highly expressed in pancreas; weakly expressed in muscle. The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity). ERBB receptor binding is elicited entirely by the EGF-like domain. Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. Belongs to the neuregulin family. receptor binding extracellular region extracellular space plasma membrane nervous system development growth factor activity membrane integral component of membrane intracellular signal transduction uc292hjw.1 uc292hjw.2 
ENSMUST00000130206.2 Gm11209 ENSMUST00000130206.2 Gm11209 (from geneSymbol) AK137943 ENSMUST00000130206.1 uc290ndj.1 uc290ndj.2 uc290ndj.1 uc290ndj.2 
ENSMUST00000130216.3 Srsf3 ENSMUST00000130216.3 serine and arginine-rich splicing factor 3, transcript variant 1 (from RefSeq NM_013663.5) ENSMUST00000130216.1 ENSMUST00000130216.2 NM_013663 O08831 P23152 P84104 Q564E9 SRSF3_MOUSE Sfrs3 Srp20 X16 uc008bsd.1 uc008bsd.2 uc008bsd.3 uc008bsd.4 The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]. Splicing factor that specifically promotes exon-inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. Also functions as export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA- binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A- containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. RNA-binding is semi-sequence specific. Interacts with CPSF6 (By similarity). Interacts with RBMY1A1 (By similarity). Interacts with SREK1/SFRS12 (By similarity). Interacts with NXF1 (By similarity). Interacts with YTHDC1, leading to recruitment to RNA elements adjacent to m6A sites (PubMed:29799838). Nucleus Nucleus speckle Cytoplasm Note=Recruited to nuclear speckles following interaction with YTHDC1. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P84104-1, P23152-1; Sequence=Displayed; Name=Short; IsoId=P84104-2, P23152-2; Sequence=VSP_005861, VSP_005862; Highest expression in thymus and pre-B cell lines; high, in testis, brain and spleen; very low in heart and not detectable in liver and kidney. Isoform long is induced by serum; in a tissue culture. Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain. [Isoform Short]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the splicing factor SR family. regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding nucleus cytoplasm mRNA processing mRNA export from nucleus insulin receptor signaling pathway RNA splicing nuclear speck phospholipase binding mRNA cis splicing, via spliceosome regulation of mRNA splicing, via spliceosome mRNA transport sequence-specific mRNA binding cellular response to leukemia inhibitory factor uc008bsd.1 uc008bsd.2 uc008bsd.3 uc008bsd.4 
ENSMUST00000130218.8 Mettl4-ps1 ENSMUST00000130218.8 Mettl4-ps1 (from geneSymbol) AK016064 ENSMUST00000130218.1 ENSMUST00000130218.2 ENSMUST00000130218.3 ENSMUST00000130218.4 ENSMUST00000130218.5 ENSMUST00000130218.6 ENSMUST00000130218.7 uc008dml.1 uc008dml.2 uc008dml.3 uc008dml.1 uc008dml.2 uc008dml.3 
ENSMUST00000130244.2 Gm15845 ENSMUST00000130244.2 Gm15845 (from geneSymbol) ENSMUST00000130244.1 uc289elj.1 uc289elj.2 uc289elj.1 uc289elj.2 
ENSMUST00000130251.2 Gm7598 ENSMUST00000130251.2 Gm7598 (from geneSymbol) AK139935 ENSMUST00000130251.1 uc292nvk.1 uc292nvk.2 uc292nvk.1 uc292nvk.2 
ENSMUST00000130256.3 B930095G15Rik ENSMUST00000130256.3 RIKEN cDNA B930095G15 gene (from RefSeq NR_155502.1) ENSMUST00000130256.1 ENSMUST00000130256.2 NR_155502 uc288wny.1 uc288wny.2 uc288wny.1 uc288wny.2 
ENSMUST00000130262.3 Gm14055 ENSMUST00000130262.3 Gm14055 (from geneSymbol) ENSMUST00000130262.1 ENSMUST00000130262.2 uc290avy.1 uc290avy.2 uc290avy.3 uc290avy.1 uc290avy.2 uc290avy.3 
ENSMUST00000130296.2 Gm16090 ENSMUST00000130296.2 predicted gene 16090 (from RefSeq NR_155534.1) ENSMUST00000130296.1 NR_155534 uc289ogu.1 uc289ogu.2 uc289ogu.1 uc289ogu.2 
ENSMUST00000130300.3 Ccbe1 ENSMUST00000130300.3 collagen and calcium binding EGF domains 1 (from RefSeq NM_178793.4) A7MCU5 CCBE1_MOUSE ENSMUST00000130300.1 ENSMUST00000130300.2 Kiaa1983 NM_178793 Q3MI99 Q5DTT5 Q8BFW1 Q8BMT1 uc008ffr.1 uc008ffr.2 uc008ffr.3 uc008ffr.4 Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Secreted Belongs to the CCBE1 family. Sequence=BAD90476.1; Type=Erroneous initiation; Evidence=; angiogenesis lymph vessel development lymphangiogenesis protease binding sprouting angiogenesis respiratory system process calcium ion binding collagen binding extracellular region collagen trimer extracellular space multicellular organism development respiratory gaseous exchange positive regulation of vascular endothelial growth factor production positive regulation of endothelial cell migration positive regulation of protein processing lung development extracellular matrix positive regulation of angiogenesis venous blood vessel morphogenesis positive regulation of vascular endothelial growth factor signaling pathway positive regulation of lymphangiogenesis uc008ffr.1 uc008ffr.2 uc008ffr.3 uc008ffr.4 
ENSMUST00000130320.8 Fbxo7 ENSMUST00000130320.8 F-box protein 7, transcript variant 1 (from RefSeq NM_153195.2) ENSMUST00000130320.1 ENSMUST00000130320.2 ENSMUST00000130320.3 ENSMUST00000130320.4 ENSMUST00000130320.5 ENSMUST00000130320.6 ENSMUST00000130320.7 FBX7_MOUSE NM_153195 Q3U7U3 Q3UBC1 Q8K0A5 uc007gnk.1 uc007gnk.2 uc007gnk.3 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway. Inhibits NF- kappa-B pathway also by promoting the ubiquitinatioin of TRAF2 (By similarity). Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains (PubMed:27497298). Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death (By similarity). Protein modification; protein ubiquitination. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO7) formed of CUL1, SKP1, RBX1 and FBXO7. Interacts via its C-terminal proline-rich region with DLGAP5. Interacts with BIRC2. Interacts with CDK6 and promotes its interaction with D-type cyclin. Interacts (via the N-terminal Ubl domain) with PRKN. Interacts (via N- terminal region) with PINK1. Interacts with PSMF1 (By similarity). Cytoplasm Nucleus Mitochondrion Cytoplasm, cytosol Note=Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria (By similarity). The ubiquitin-like region mediates interaction with PRKN. The proline-rich region is important for protein-protein interactions. FBXO7-deletion mice expired without exception at the beginning of the fourth postnatal week, independently of gender. Before the fourth week, mice displayed significantly lower body and brain weights. ubiquitin ligase complex mitophagy nucleus cytoplasm mitochondrion cytosol ubiquitin-dependent protein catabolic process protein targeting to mitochondrion regulation of neuron projection development protein ubiquitination protein kinase binding ubiquitin protein ligase binding regulation of protein stability macromolecular complex regulation of locomotion ubiquitin binding negative regulation of lymphocyte differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity protein heterodimerization activity glial cytoplasmic inclusion classical Lewy body Lewy neurite negative regulation of neuron death negative regulation of oxidative stress-induced neuron death negative regulation of hydrogen peroxide-induced neuron death positive regulation of mitophagy Lewy body core Lewy body corona negative regulation of G1/S transition of mitotic cell cycle uc007gnk.1 uc007gnk.2 uc007gnk.3 
ENSMUST00000130325.8 Lsm6 ENSMUST00000130325.8 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated, transcript variant 1 (from RefSeq NM_001191004.1) ENSMUST00000130325.1 ENSMUST00000130325.2 ENSMUST00000130325.3 ENSMUST00000130325.4 ENSMUST00000130325.5 ENSMUST00000130325.6 ENSMUST00000130325.7 Lsm6 NM_001191004 Q542U7 Q542U7_MOUSE uc009mif.1 uc009mif.2 uc009mif.3 uc009mif.4 Cytoplasm Nucleus Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily. mRNA splicing, via spliceosome RNA binding nucleus spliceosomal complex small nucleolar ribonucleoprotein complex mRNA processing RNA splicing U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome uc009mif.1 uc009mif.2 uc009mif.3 uc009mif.4 
ENSMUST00000130360.2 Synpo ENSMUST00000130360.2 Belongs to the synaptopodin family. (from UniProt E9Q3E2) BC065127 E9Q3E2 E9Q3E2_MOUSE ENSMUST00000130360.1 Synpo uc008faq.1 uc008faq.2 uc008faq.3 uc008faq.4 Belongs to the synaptopodin family. actin binding positive regulation of actin filament bundle assembly uc008faq.1 uc008faq.2 uc008faq.3 uc008faq.4 
ENSMUST00000130367.8 Trim26 ENSMUST00000130367.8 tripartite motif-containing 26, transcript variant 4 (from RefSeq NM_001286727.1) B8JJ55 ENSMUST00000130367.1 ENSMUST00000130367.2 ENSMUST00000130367.3 ENSMUST00000130367.4 ENSMUST00000130367.5 ENSMUST00000130367.6 ENSMUST00000130367.7 NM_001286727 Q8C9E9 Q8JZT7 Q99PN2 Q99PN3 TRI26_MOUSE Znf173 uc033hdq.1 uc033hdq.2 uc033hdq.3 E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Plays also a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA. Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling (PubMed:34017102). In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation. Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein. Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (By similarity). Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (PubMed:33869196). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Interacts with TBK1; this interaction bridges together TBK1 and NEMO in order to activate TBK1. Interacts with INCA1. Cytoplasm Nucleus Note=Viral infection mediates TRIM26 nuclear translocation. Event=Alternative splicing; Named isoforms=2; Name=Alpha; IsoId=Q99PN3-1; Sequence=Displayed; Name=Beta; IsoId=Q99PN3-2; Sequence=VSP_010812, VSP_010813; Autoubiquitinates upon viral infection. In turn, autoubiquitinated TRIM26 recruits NEMO and bridges TBK1-NEMO interaction. TRIM26 attenuatess the production of proinflammatory cytokines in response to TLR ligands, TNF-alpha, and IL-1beta stimulation. In addition, the challenge of TRIM26-deletion mice with LPS results in inflammatory responses that are less lethal than those in wild-type mice. Belongs to the TRIM/RBCC family. immune system process nucleus cytoplasm zinc ion binding transferase activity innate immune response negative regulation of viral entry into host cell metal ion binding positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of viral release from host cell uc033hdq.1 uc033hdq.2 uc033hdq.3 
ENSMUST00000130372.3 Cd209g ENSMUST00000130372.3 CD209g antigen (from RefSeq NM_027343.3) Cd209g D3Z5D4 D3Z5D4_MOUSE ENSMUST00000130372.1 ENSMUST00000130372.2 NM_027343 uc029wqi.1 uc029wqi.2 uc029wqi.3 cellular_component biological_process carbohydrate binding uc029wqi.1 uc029wqi.2 uc029wqi.3 
ENSMUST00000130373.2 4732490B19Rik ENSMUST00000130373.2 RIKEN cDNA 4732490B19 gene (from RefSeq NR_040276.1) ENSMUST00000130373.1 NR_040276 uc007mej.1 uc007mej.2 uc007mej.1 uc007mej.2 
ENSMUST00000130379.9 Fbxo11 ENSMUST00000130379.9 F-box protein 11, transcript variant 6 (from RefSeq NM_001414440.1) A1A595 E9QP06 ENSMUST00000130379.1 ENSMUST00000130379.2 ENSMUST00000130379.3 ENSMUST00000130379.4 ENSMUST00000130379.5 ENSMUST00000130379.6 ENSMUST00000130379.7 ENSMUST00000130379.8 FBX11_MOUSE NM_001414440 Q08EB9 Q08EC0 Q7TPD1 Q80UP0 uc289njy.1 uc289njy.2 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis. Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks. Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL- 1beta. Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome. Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis. Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1. Protein modification; protein ubiquitination. Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated). Interacts with PRMD1. Interacts with TRAF3. Interacts with CIITA. Interacts with BAHD1. Q7TPD1; P41183: Bcl6; NbExp=2; IntAct=EBI-15955324, EBI-6253762; Nucleus Chromosome Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7TPD1-1; Sequence=Displayed; Name=2; IsoId=Q7TPD1-2; Sequence=VSP_053353; Name=3; IsoId=Q7TPD1-3; Sequence=VSP_053353, VSP_053354; At 9.5 dpc and 10.5 dpc, expression is restricted to developing heart tissue. By 11.5 dpc and 12.5 dpc, detected in liver and subsequently in muscle by 13.5 dpc. At 14.5 dpc, still detected in heart, liver and muscle and also in the developing secondary palate including the nasal, medial and oral epithelia of the palatal shelves. At 15.5 dpc and 16.5 dpc, expressed in lung, kidney, heart, liver, muscle and adrenal gland. At this time, fusion of the palate shelves has occurred, with expression confined to the nasal and oral epithelia. At 17.5 dpc, expression in the lung is confined to bronchial epithelial cells and is evident in bone marrow, skin, tissue macrophages, osteoblasts, kidney, liver and spleen. At 18.5 dpc, expressed in bone marrow, liver, kidney and muscle but decreases in heart and lung. At this time, first detected in the middle ear epithelium. At the newborn stage, expression is strong in the middle ear where it is confined to mucin-secreting cells, as well as persisting in bone marrow, kidney and liver. Middle ear expression persists in postnatal head tissue at 4 and 13 days after birth and has declined by 21 days after birth. In the adult, expression is seen in alveolar macrophages of the lung, glomeruli and collecting tubules of the kidney, midbrain, heart and muscle. Not detected at 8.5 dpc. Expressed from 9.5 dpc throughout development and into adulthood (at protein level). ubiquitin ligase complex ubiquitin-protein transferase activity protein binding nucleus chromosome nucleolus cytoplasm cytosol cellular protein modification process ubiquitin-dependent protein catabolic process sensory perception of sound zinc ion binding protein-arginine N-methyltransferase activity protein ubiquitination peptidyl-arginine N-methylation regulation of apoptotic process metal ion binding uc289njy.1 uc289njy.2 
ENSMUST00000130405.2 Arhgap20 ENSMUST00000130405.2 Arhgap20 (from geneSymbol) AK129345 Arhgap20 D3YUH8 D3YUH8_MOUSE ENSMUST00000130405.1 uc292hga.1 uc292hga.2 GTPase activator activity signal transduction positive regulation of GTPase activity uc292hga.1 uc292hga.2 
ENSMUST00000130411.7 Srsf6 ENSMUST00000130411.7 serine and arginine-rich splicing factor 6 (from RefSeq NM_026499.4) ENSMUST00000130411.1 ENSMUST00000130411.2 ENSMUST00000130411.3 ENSMUST00000130411.4 ENSMUST00000130411.5 ENSMUST00000130411.6 NM_026499 Q3TWW8 Q3UJV5 Q921K3 Q9DBP1 SRSF6_MOUSE Sfrs6 Srp55 uc008nsc.1 uc008nsc.2 uc008nsc.3 uc008nsc.4 uc008nsc.5 The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133872.1, AK159519.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre- mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity). Binds SREK1/SFRS12. Interacts with DYRK1A (By similarity). Nucleus Nucleus speckle Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10 (By similarity). Belongs to the splicing factor SR family. alternative mRNA splicing, via spliceosome regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding protein binding nucleus mRNA splice site selection mRNA processing RNA splicing negative regulation of gene expression regulation of keratinocyte proliferation nuclear speck response to insulin pre-mRNA binding mRNA cis splicing, via spliceosome negative regulation of keratinocyte differentiation negative regulation of mRNA splicing, via spliceosome positive regulation of epithelial cell proliferation involved in lung morphogenesis negative regulation of cell death regulation of wound healing negative regulation of type B pancreatic cell apoptotic process uc008nsc.1 uc008nsc.2 uc008nsc.3 uc008nsc.4 uc008nsc.5 
ENSMUST00000130416.2 Gm13936 ENSMUST00000130416.2 Gm13936 (from geneSymbol) ENSMUST00000130416.1 uc289zdk.1 uc289zdk.2 uc289zdk.1 uc289zdk.2 
ENSMUST00000130418.8 Aldh1l1 ENSMUST00000130418.8 Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:31624291). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity). (from UniProt Q8R0Y6) AL1L1_MOUSE Aldh1l1 BC030730 ENSMUST00000130418.1 ENSMUST00000130418.2 ENSMUST00000130418.3 ENSMUST00000130418.4 ENSMUST00000130418.5 ENSMUST00000130418.6 ENSMUST00000130418.7 Fthfd Q8R0Y6 uc009cxm.1 uc009cxm.2 uc009cxm.3 Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:31624291). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity). Reaction=(6R)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8- tetrahydrofolate + CO2 + H(+) + NADPH; Xref=Rhea:RHEA:10180, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:195366; EC=1.5.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10181; Evidence=; Homotetramer. Cytoplasm, cytosol Highly expressed in liver (at protein level) (PubMed:31624291). Also expressed in pancreas, brain and lung (at protein level) (PubMed:31624291). The N-terminal hydrolase domain has an NADP-independent formyltetrahydrofolate hydrolase activity, releasing formate and tetrahydrofolate. The C-terminal aldehyde dehydrogenase domain has an NADP- dependent dehydrogenase activity. It catalyzes the oxidation of formate, released by the hydrolysis of formyltetrahydrofolate, into CO2. The carrier domain is phosphopantetheinylated and uses the 4'- phosphopantetheine/4'-PP swinging arm to transfer the formyl group released by the N-terminal formyltetrahydrofolate hydrolase activity to the C-terminal aldehyde dehydrogenase domain that catalyzes its NADP- dependent oxidation into CO2. The overall NADP-dependent physiological reaction requires the 3 domains (N-terminal hydrolase, C-terminal aldehyde dehydrogenase and carrier domains) to convert formyltetrahydrofolate into tetrahydrofolate and CO2. Phosphopantetheinylation at Ser-354 by AASDHPPT is required for the formyltetrahydrofolate dehydrogenase activity. Homozygous knockout mice are viable, fertile, develop normally and do not display overt phenotype (PubMed:31624291). However, they have metabolic signs of folate deficiency like the accumulation of formiminoglutamate (PubMed:31624291). Mice show reduced hepatic folate pools with a strong accumulation of (6S)-10- formyltetrahydrofolate and a significant drop in tetrahydrofolate levels (PubMed:31624291). This is associated with a strong decrease of glycine levels as well as levels of several glycine conjugates (PubMed:31624291). In the N-terminal section; belongs to the GART family. In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. catalytic activity aldehyde dehydrogenase (NAD) activity aldehyde dehydrogenase [NAD(P)+] activity protein binding cytoplasm mitochondrion cytosol one-carbon metabolic process biosynthetic process 10-formyltetrahydrofolate catabolic process formyltetrahydrofolate dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor hydroxymethyl-, formyl- and related transferase activity macromolecular complex aldehyde dehydrogenase (NADP+) activity macromolecular complex binding oxidation-reduction process uc009cxm.1 uc009cxm.2 uc009cxm.3 
ENSMUST00000130442.3 Gm11505 ENSMUST00000130442.3 Gm11505 (from geneSymbol) ENSMUST00000130442.1 ENSMUST00000130442.2 uc288bfm.1 uc288bfm.2 uc288bfm.3 uc288bfm.1 uc288bfm.2 uc288bfm.3 
ENSMUST00000130451.2 Erp29 ENSMUST00000130451.2 endoplasmic reticulum protein 29 (from RefSeq NM_026129.2) ENSMUST00000130451.1 ERP29_MOUSE NM_026129 P57759 Q3THW3 Q9CQ42 uc008zjf.1 uc008zjf.2 uc008zjf.3 Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER. Homodimer. Part of a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (By similarity). Endoplasmic reticulum lumen lanosome activation of MAPK activity positive regulation of protein phosphorylation endoplasmic reticulum endoplasmic reticulum lumen smooth endoplasmic reticulum ER to Golgi vesicle-mediated transport protein secretion cell surface positive regulation of gene expression negative regulation of gene expression transport vesicle melanosome protein homodimerization activity negative regulation of protein secretion chaperone binding regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway uc008zjf.1 uc008zjf.2 uc008zjf.3 
ENSMUST00000130458.8 Zfp963 ENSMUST00000130458.8 zinc finger protein 963 (from RefSeq NM_001200023.1) D3Z2T8 D3Z2T8_MOUSE ENSMUST00000130458.1 ENSMUST00000130458.2 ENSMUST00000130458.3 ENSMUST00000130458.4 ENSMUST00000130458.5 ENSMUST00000130458.6 ENSMUST00000130458.7 NM_001200023 Zfp963 uc009lxo.1 uc009lxo.2 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc009lxo.1 uc009lxo.2 
ENSMUST00000130481.2 Plcxd2 ENSMUST00000130481.2 phosphatidylinositol-specific phospholipase C, X domain containing 2 (from RefSeq NM_001134480.1) B2RXA1 ENSMUST00000130481.1 NM_001134480 PLCX2_MOUSE uc007zje.1 uc007zje.2 uc007zje.3 uc007zje.4 Nucleus Expressed at highest levels in brain, followed by stomach and small intestine. Detected at low levels in kidney, ey, thymus and slkeletal muscle. molecular_function cellular_component nucleus lipid metabolic process signal transduction phosphoric diester hydrolase activity biological_process lipid catabolic process hydrolase activity uc007zje.1 uc007zje.2 uc007zje.3 uc007zje.4 
ENSMUST00000130486.2 Gm15675 ENSMUST00000130486.2 Gm15675 (from geneSymbol) AK140991 ENSMUST00000130486.1 uc287lmo.1 uc287lmo.2 uc287lmo.1 uc287lmo.2 
ENSMUST00000130490.10 Zfp783 ENSMUST00000130490.10 zinc finger protein 783 (from RefSeq NR_027963.1) ENSMUST00000130490.1 ENSMUST00000130490.2 ENSMUST00000130490.3 ENSMUST00000130490.4 ENSMUST00000130490.5 ENSMUST00000130490.6 ENSMUST00000130490.7 ENSMUST00000130490.8 ENSMUST00000130490.9 NR_027963 uc009btq.1 uc009btq.2 uc009btq.3 uc009btq.4 uc009btq.1 uc009btq.2 uc009btq.3 uc009btq.4 
ENSMUST00000130491.3 Cebpg ENSMUST00000130491.3 CCAAT/enhancer binding protein gamma (from RefSeq NM_009884.3) Cebpg ENSMUST00000130491.1 ENSMUST00000130491.2 NM_009884 Q54AJ1 Q54AJ1_MOUSE uc009gjk.1 uc009gjk.2 uc009gjk.3 Belongs to the bZIP family. C/EBP subfamily. transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding liver development DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription factor binding protein homodimerization activity sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending positive regulation of DNA repair positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity uc009gjk.1 uc009gjk.2 uc009gjk.3 
ENSMUST00000130493.2 Gm12158 ENSMUST00000130493.2 Gm12158 (from geneSymbol) ENSMUST00000130493.1 uc287xos.1 uc287xos.2 uc287xos.1 uc287xos.2 
ENSMUST00000130498.2 Bola2 ENSMUST00000130498.2 bolA family member 2 (from RefSeq NM_175103.3) BOLA2_MOUSE ENSMUST00000130498.1 NM_175103 Q0P601 Q8BGS2 uc009jsj.1 uc009jsj.2 uc009jsj.3 Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts together with the monothiol glutaredoxin GLRX3. Interacts with GLRX3; forms a heterotrimeric complex composed by two BOLA2 molecules and one GLRX3 molecule; linked by [2Fe-2S] clusters. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGS2-1; Sequence=Displayed; Name=2; IsoId=Q8BGS2-2; Sequence=VSP_010094; Belongs to the BolA/IbaG family. molecular_function cellular_component nucleus cytoplasm biological_process [2Fe-2S] cluster assembly protein maturation by iron-sulfur cluster transfer uc009jsj.1 uc009jsj.2 uc009jsj.3 
ENSMUST00000130504.8 Spata3 ENSMUST00000130504.8 spermatogenesis associated 3, transcript variant 4 (from RefSeq NM_001122732.2) ENSMUST00000130504.1 ENSMUST00000130504.2 ENSMUST00000130504.3 ENSMUST00000130504.4 ENSMUST00000130504.5 ENSMUST00000130504.6 ENSMUST00000130504.7 NM_001122732 Q80ZS4 Q9D5L5 Q9D9T6 Q9DAF5 SPTA3_MOUSE Tsarg1 uc007buw.1 uc007buw.2 uc007buw.3 uc007buw.4 Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9D9T6-1; Sequence=Displayed; Name=2; IsoId=Q9D9T6-2; Sequence=VSP_008525; Name=3; IsoId=Q9D9T6-3; Sequence=VSP_008525, VSP_008526, VSP_008527; Name=4; IsoId=Q9D9T6-4; Sequence=VSP_008523, VSP_008524; Strongly expressed in testis. Faintly expressed in epididymis, ovary, spleen, kidney, lung, heart, brain, epididymis, liver and skeletal muscle. [Isoform 2]: May be due to competing acceptor splice site. [Isoform 3]: May be due to competing acceptor splice site and by intron retention. [Isoform 4]: May be due to competing donor splice site. molecular_function cellular_component biological_process uc007buw.1 uc007buw.2 uc007buw.3 uc007buw.4 
ENSMUST00000130509.10 Wdfy4 ENSMUST00000130509.10 Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells (PubMed:30409884). Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking (PubMed:30409884). Also plays a role in B-cell survival through regulation of autophagy (PubMed:30257884). (from UniProt E9Q2M9) AK155186 E9Q2M9 ENSMUST00000130509.1 ENSMUST00000130509.2 ENSMUST00000130509.3 ENSMUST00000130509.4 ENSMUST00000130509.5 ENSMUST00000130509.6 ENSMUST00000130509.7 ENSMUST00000130509.8 ENSMUST00000130509.9 WDFY4_MOUSE Wdfy4 uc288shf.1 uc288shf.2 Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells (PubMed:30409884). Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking (PubMed:30409884). Also plays a role in B-cell survival through regulation of autophagy (PubMed:30257884). Interacts with HSP90AB1. Early endosome Endoplasmic reticulum Highly expressed in immune tissues, especially B lymphocytes. Mice are unable to cross-present in vivo (PubMed:30409884). In addition, affects the development of B-cells with a block in the transition between the pro- and pre-B cell stages in bone marrow (PubMed:30257884). uc288shf.1 uc288shf.2 
ENSMUST00000130532.2 9430024E24Rik ENSMUST00000130532.2 9430024E24Rik (from geneSymbol) AK020435 ENSMUST00000130532.1 uc057lcl.1 uc057lcl.2 uc057lcl.3 uc057lcl.1 uc057lcl.2 uc057lcl.3 
ENSMUST00000130560.8 Apod ENSMUST00000130560.8 apolipoprotein D, transcript variant 1 (from RefSeq NM_007470.4) APOD_MOUSE ENSMUST00000130560.1 ENSMUST00000130560.2 ENSMUST00000130560.3 ENSMUST00000130560.4 ENSMUST00000130560.5 ENSMUST00000130560.6 ENSMUST00000130560.7 NM_007470 P51910 Q3TZE7 uc007yxf.1 uc007yxf.2 uc007yxf.3 The protein encoded by this gene is a component of high-density lipoprotein (HDL), but is unique in that it shares greater structural similarity to lipocalin than to other members of the apolipoprotein family, and has a wider tissue expression pattern. The encoded protein is involved in lipid metabolism, and ablation of this gene results in defects in triglyceride metabolism. Elevated levels of this gene product have been observed in multiple tissues of Niemann-Pick disease mouse models, as well as in some tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. APOD occurs in the macromolecular complex with lecithin- transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts. Homodimer. Secreted. Highest levels of expression in brain, testis, virgin mammary gland and salivary gland. Moderate levels in skeletal muscle, lactating mammary gland and thymus. Low levels in lung and lymph node. No expression in kidney, pancreas, liver or spleen. Belongs to the calycin superfamily. Lipocalin family. response to reactive oxygen species extracellular region extracellular space cytoplasm endoplasmic reticulum glucose metabolic process lipid metabolic process lipid transport brain development aging lipid binding negative regulation of platelet-derived growth factor receptor signaling pathway peripheral nervous system axon regeneration cholesterol binding cytosolic ribosome dendrite tissue regeneration negative regulation of protein import into nucleus response to drug neuronal cell body perinuclear region of cytoplasm negative regulation of smooth muscle cell proliferation response to axon injury negative regulation of focal adhesion assembly negative regulation of lipoprotein lipid oxidation negative regulation of monocyte chemotactic protein-1 production negative regulation of cytokine production involved in inflammatory response negative regulation of smooth muscle cell-matrix adhesion negative regulation of T cell migration uc007yxf.1 uc007yxf.2 uc007yxf.3 
ENSMUST00000130576.3 Gm12631 ENSMUST00000130576.3 Gm12631 (from geneSymbol) ENSMUST00000130576.1 ENSMUST00000130576.2 KY467989 uc290nqr.1 uc290nqr.2 uc290nqr.3 uc290nqr.1 uc290nqr.2 uc290nqr.3 
ENSMUST00000130582.2 Gm11823 ENSMUST00000130582.2 Gm11823 (from geneSymbol) AK086332 ENSMUST00000130582.1 uc290lgr.1 uc290lgr.2 uc290lgr.1 uc290lgr.2 
ENSMUST00000130584.2 Gm16142 ENSMUST00000130584.2 Gm16142 (from geneSymbol) AK042534 ENSMUST00000130584.1 uc292lzh.1 uc292lzh.2 uc292lzh.1 uc292lzh.2 
ENSMUST00000130607.2 Gm16195 ENSMUST00000130607.2 Gm16195 (from geneSymbol) ENSMUST00000130607.1 uc289jej.1 uc289jej.2 uc289jej.1 uc289jej.2 
ENSMUST00000130634.2 Gm14015 ENSMUST00000130634.2 predicted gene 14015 (from RefSeq NR_040637.1) ENSMUST00000130634.1 NR_040637 uc029udv.1 uc029udv.2 uc029udv.1 uc029udv.2 
ENSMUST00000130643.9 Srpk1 ENSMUST00000130643.9 serine/arginine-rich protein specific kinase 1 (from RefSeq NM_016795.4) ENSMUST00000130643.1 ENSMUST00000130643.2 ENSMUST00000130643.3 ENSMUST00000130643.4 ENSMUST00000130643.5 ENSMUST00000130643.6 ENSMUST00000130643.7 ENSMUST00000130643.8 NM_016795 Q3UB06 Q3UB06_MOUSE Srpk1 uc008bri.1 uc008bri.2 uc008bri.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm cytosol plasma membrane protein phosphorylation chromosome segregation intracellular signal transduction positive regulation of viral genome replication negative regulation of viral genome replication regulation of mRNA processing uc008bri.1 uc008bri.2 uc008bri.3 
ENSMUST00000130645.8 Mtfr1 ENSMUST00000130645.8 mitochondrial fission regulator 1, transcript variant 4 (from RefSeq NR_045575.2) Chppr ENSMUST00000130645.1 ENSMUST00000130645.2 ENSMUST00000130645.3 ENSMUST00000130645.4 ENSMUST00000130645.5 ENSMUST00000130645.6 ENSMUST00000130645.7 Kiaa0009 MTFR1_MOUSE NR_045575 Q99MB2 Q9CQZ4 uc008orr.1 uc008orr.2 uc008orr.3 uc008orr.4 uc008orr.5 May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission. Mitochondrion Note=May be associated with the inner and the outer mitochondrial membrane. Ubiquitously expressed with higher expression in testis. Mice are viable and fertile. However, oxidative DNA damages appear in the testis, associated with a reduced expression of genes encoding enzymes with oxidoreductase activity. Belongs to the MTFR1 family. mitochondrial fission mitochondrion cytosol plasma membrane mitochondrion organization aerobic respiration uc008orr.1 uc008orr.2 uc008orr.3 uc008orr.4 uc008orr.5 
ENSMUST00000130696.8 4930511M06Rik ENSMUST00000130696.8 4930511M06Rik (from geneSymbol) AK165835 ENSMUST00000130696.1 ENSMUST00000130696.2 ENSMUST00000130696.3 ENSMUST00000130696.4 ENSMUST00000130696.5 ENSMUST00000130696.6 ENSMUST00000130696.7 uc008ezc.1 uc008ezc.2 uc008ezc.3 uc008ezc.4 uc008ezc.1 uc008ezc.2 uc008ezc.3 uc008ezc.4 
ENSMUST00000130697.8 Irf9 ENSMUST00000130697.8 interferon regulatory factor 9, transcript variant 3 (from RefSeq NM_008394.3) ENSMUST00000130697.1 ENSMUST00000130697.2 ENSMUST00000130697.3 ENSMUST00000130697.4 ENSMUST00000130697.5 ENSMUST00000130697.6 ENSMUST00000130697.7 IRF9_MOUSE Isgf3g NM_008394 Q61179 uc007tzl.1 uc007tzl.2 uc007tzl.3 Transcription factor that plays an essential role in anti- viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Interacts with STAT2 in the cytoplasm. Forms the interferon- stimulated gene factor 3 complex (ISGF3) with the heterodimer STAT1:STAT2; upon stimulation. Q61179; Q9QXJ2: Stat2; NbExp=10; IntAct=EBI-646653, EBI-646643; Nucleus. By IFN-alpha and IFN-beta. Upon stimulation the regulatory phosphorylated alpha and beta subunits assemble with the gamma subunit and translocate from the cytoplasm to the nucleus. Belongs to the IRF family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding immune system process DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription regulatory region DNA binding type I interferon biosynthetic process uc007tzl.1 uc007tzl.2 uc007tzl.3 
ENSMUST00000130722.3 Or8h6 ENSMUST00000130722.3 olfactory receptor 1096 (from RefSeq NM_001370760.1) A0A1L1SUP2 A0A1L1SUP2_MOUSE ENSMUST00000130722.1 ENSMUST00000130722.2 NM_001370760 Olfr1096 Or8h6 uc289xtg.1 uc289xtg.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB173053.1, DR065777.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xtg.1 uc289xtg.2 
ENSMUST00000130733.2 Gm11536 ENSMUST00000130733.2 predicted gene 11536 (from RefSeq NR_188973.1) ENSMUST00000130733.1 NR_188973 uc288brb.1 uc288brb.2 uc288brb.1 uc288brb.2 
ENSMUST00000130734.2 Gm4409 ENSMUST00000130734.2 Gm4409 (from geneSymbol) AK033053 ENSMUST00000130734.1 uc291fyy.1 uc291fyy.2 uc291fyy.1 uc291fyy.2 
ENSMUST00000130771.3 Gm2044 ENSMUST00000130771.3 Gm2044 (from geneSymbol) AK144366 ENSMUST00000130771.1 ENSMUST00000130771.2 uc009kgh.1 uc009kgh.2 uc009kgh.3 uc009kgh.1 uc009kgh.2 uc009kgh.3 
ENSMUST00000130773.2 Gm13479 ENSMUST00000130773.2 Gm13479 (from geneSymbol) AK039697 ENSMUST00000130773.1 uc289vyq.1 uc289vyq.2 uc289vyq.1 uc289vyq.2 
ENSMUST00000130825.8 Zfp993 ENSMUST00000130825.8 Belongs to the krueppel C2H2-type zinc-finger protein family. (from UniProt A2A8V4) A2A8V4 A2A8V4_MOUSE AK006496 ENSMUST00000130825.1 ENSMUST00000130825.2 ENSMUST00000130825.3 ENSMUST00000130825.4 ENSMUST00000130825.5 ENSMUST00000130825.6 ENSMUST00000130825.7 Zfp993 uc290rqz.1 uc290rqz.2 Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc290rqz.1 uc290rqz.2 
ENSMUST00000130837.2 Gm12324 ENSMUST00000130837.2 Gm12324 (from geneSymbol) AK039680 ENSMUST00000130837.1 uc287zvc.1 uc287zvc.2 uc287zvc.1 uc287zvc.2 
ENSMUST00000130859.2 Gssos2 ENSMUST00000130859.2 Gssos2 (from geneSymbol) ENSMUST00000130859.1 uc290bsb.1 uc290bsb.2 uc290bsb.1 uc290bsb.2 
ENSMUST00000130860.2 Gm12289 ENSMUST00000130860.2 predicted gene 12289 (from RefSeq NR_188993.1) ENSMUST00000130860.1 NR_188993 uc287yyu.1 uc287yyu.2 uc287yyu.1 uc287yyu.2 
ENSMUST00000130870.2 Gm14226 ENSMUST00000130870.2 Gm14226 (from geneSymbol) AK157786 ENSMUST00000130870.1 uc290bpz.1 uc290bpz.2 uc290bpz.1 uc290bpz.2 
ENSMUST00000130871.2 Gm28043 ENSMUST00000130871.2 predicted gene, 28043 (from RefSeq NR_132314.1) E0CXC2 E0CXC2_MOUSE ENSMUST00000130871.1 Gm28043 NR_132314 RNF8 Rnf8 uc289jld.1 uc289jld.2 This locus represents naturally occurring readthrough transcription between the neighboring Rnf8 (ring finger protein 8) and Cmtr1 (cap methyltransferase 1) genes on chromosome 17. The readthrough transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Jul 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record was based on AK172991.1, which retains an intron. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 58230, 74157 ##RefSeq-Attributes-END## E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non- histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'- linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'- linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA- mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm. Nucleus Cytoplasm Midbody Chromosome, telomere Note=Recruited at uncapped telomeres. Following DNA double-strand breaks, recruited to the sites of damage. During prophase, concomitant with nuclear envelope breakdown, localizes throughout the cell, with a dotted pattern. In telophase, again in the nucleus and also with a discrete dotted pattern in the cytoplasm. In late telophase and during cytokinesis, localizes in the midbody of the tubulin bridge joining the daughter cells. Does not seem to be associated with condensed chromosomes at any time during the cell cycle. During spermatogenesis, sequestered in the cytoplasm by PIWIL1: RNF8 is released following ubiquitination and degradation of PIWIL1. The FHA domain specifically recognizes and binds ATM- phosphorylated MDC1 and phosphorylated HERC2. Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger. Belongs to the CHFR family. Belongs to the RNF8 family. According to a well-established model, RNF8 initiate H2A 'Lys- 63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non- histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data. ubiquitin ligase complex chromosome, telomeric region nucleic acid binding chromatin binding ubiquitin-protein transferase activity nucleus chromosome cytoplasm cytosol DNA repair double-strand break repair chromatin organization ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus cell cycle response to ionizing radiation protein ubiquitination transferase activity midbody histone H2A ubiquitination histone H2B ubiquitination site of double-strand break histone binding ubiquitin binding positive regulation of DNA repair metal ion binding cell division ubiquitin protein ligase activity histone H2A K63-linked ubiquitination protein K48-linked ubiquitination uc289jld.1 uc289jld.2 
ENSMUST00000130872.3 Gm17216 ENSMUST00000130872.3 Gm17216 (from geneSymbol) ENSMUST00000130872.1 ENSMUST00000130872.2 uc291kji.1 uc291kji.2 uc291kji.1 uc291kji.2 
ENSMUST00000130911.8 Nfyb ENSMUST00000130911.8 nuclear transcription factor-Y beta (from RefSeq NM_010914.2) ENSMUST00000130911.1 ENSMUST00000130911.2 ENSMUST00000130911.3 ENSMUST00000130911.4 ENSMUST00000130911.5 ENSMUST00000130911.6 ENSMUST00000130911.7 NFYB_MOUSE NM_010914 P22569 P63139 Q3UK54 uc007gjv.1 uc007gjv.2 uc007gjv.3 Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP (By similarity). Nucleus. Event=Alternative splicing; Named isoforms=1; Comment=3 isoforms may be produced.; Name=1; IsoId=P63139-1, P22569-1; Sequence=Displayed; Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain. Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'. Belongs to the NFYB/HAP3 subunit family. RNA polymerase II distal enhancer sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated CCAAT-binding factor complex protein-DNA complex sequence-specific DNA binding transcription regulatory region DNA binding macromolecular complex binding positive regulation of transcription, DNA-templated protein heterodimerization activity repressing transcription factor binding RNA polymerase II transcription factor complex cellular response to leukemia inhibitory factor uc007gjv.1 uc007gjv.2 uc007gjv.3 
ENSMUST00000130916.8 Becn1 ENSMUST00000130916.8 beclin 1, autophagy related, transcript variant 1 (from RefSeq NM_019584.4) BECN1_MOUSE ENSMUST00000130916.1 ENSMUST00000130916.2 ENSMUST00000130916.3 ENSMUST00000130916.4 ENSMUST00000130916.5 ENSMUST00000130916.6 ENSMUST00000130916.7 NM_019584 O88597 Q99J03 uc007loj.1 uc007loj.2 uc007loj.3 Plays a central role in autophagy (PubMed:10604474, PubMed:12372286, PubMed:19270693, PubMed:28445460). Acts as a core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:19270693, PubMed:25275521). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (PubMed:25275521). Involved in endocytosis including endosome formation in neuronal cells (PubMed:25275521). May play a role in antiviral host defense (By similarity). Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors (By similarity). A homodimeric form is proposed to exist; this metastable form readily transits to ATG14- or UVRAG-containing complexes with BECN1:UVRAG being more stable than BECN1:ATG14 (By similarity). Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex whose core is composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1, and associates with additional regulatory/auxilliary subunits to form alternative complex forms. Accepted alternative complex forms containing a forth regulatory subunit in a mutually exclusive manner are PI3K complex I (PI3KC3-C1) containing ATG14, and PI3K complex II (PI3KC3-C2) containing UVRAG (PubMed:19270693, PubMed:23332761). PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex (By similarity). Both, PI3KC3-C1 and PI3KC3-C2, can associate with further regulatory subunits, such as RUBCN, SH3GLB1/Bif-1 and AMBRA1 (PubMed:19270693). PI3KC3-C1 probably associates with PIK3CB (PubMed:21059846). Interacts with AMBRA1, GOPC, GRID2 and PIK3CB (PubMed:12372286, PubMed:17589504). Forms a complex with PPP2CA and AMBRA1; AMBRA1 and BECN1 components of the complex regulate MYC stability via different pathways (By similarity). Interacts with BCL2 and BCL2L1 isoform Bcl-X(L); the interaction inhibits BECN1 function in promoting autophagy by interfering with the formation of the PI3K complex (By similarity). Interacts with cytosolic HMGB1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy (PubMed:20819940). Interacts with USP10, USP13, VMP1, DAPK1 (By similarity). Interacts with the poly-Gln domain of ATXN3; the interaction causes deubiquitination at Lys-400 and stabilizes BECN1 (PubMed:28445460). Interacts with SLAMF1 (PubMed:22493499). Interacts with TRIM5; the interaction causes activation of BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (By similarity). Interacts with active ULK1 (phosphorylated on 'Ser-317') and MEFV simultaneously (By similarity). Interacts with TRIM50 (PubMed:29604308). Interacts with TRIM16 (By similarity). Interacts with WDR81 and WDR91; negatively regulates the PI3 kinase/PI3K activity associated with endosomal membranes (By similarity). Interacts with LAPTM4B; competes with EGFR for LAPTM4B binding; regulates EGFR activity (By similarity). Interacts with ATG14; this interaction is increased in the absence of TMEM39A (By similarity). Interacts with WASHC1; preventing interaction with AMBRA1 and the DCX(AMBRA1) complex and subsequent ubiquitination (By similarity). Interacts with TRIM17 (By similarity). Interacts with BCL2L10/BCL-B (via BH1 domain) (By similarity). Interacts with SH3BGRL (By similarity). Interacts with Irgm1; enhancing BECN1-interacting partners and influencing the composition of the BECN1 complex (By similarity). Interacts with ARMC3 (PubMed:34428398). (Microbial infection) Interacts with murine gammaherpesvirus 68 M11; the viral protein binds BECN1 with higher affinity than cellular BCL2. O88597; P10417: Bcl2; NbExp=11; IntAct=EBI-643716, EBI-526314; O88597; Q8BH60: Gopc; NbExp=5; IntAct=EBI-643716, EBI-296357; O88597; P63158: Hmgb1; NbExp=3; IntAct=EBI-643716, EBI-6665811; O88597; Q8VCQ3: Nrbf2; NbExp=5; IntAct=EBI-643716, EBI-2365563; O88597; Q6PF93: Pik3c3; NbExp=6; IntAct=EBI-643716, EBI-6678149; Cytoplasm Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Endoplasmic reticulum membrane ; Peripheral membrane protein Mitochondrion membrane ; Peripheral membrane protein Endosome Cytoplasmic vesicle, autophagosome Note=Interaction with ATG14 promotes translocation to autophagosomes (By similarity). Expressed in dendrites and cell bodies of cerebellar Purkinje cells. Localized to endosomes in neurons (PubMed:25275521). [Beclin-1-C 35 kDa]: Mitochondrion Nucleus Cytoplasm [Beclin-1-C 37 kDa]: Mitochondrion The coiled coil domain can form antiparallel homodimers and mediates dimerization with the coiled coil domains of ATG14 or UVRAG involved in the formation of PI3K complexes. The C-terminal evolutionary conserved domain (ECD) contains poly-Gln-binding domains such as the ATXN3 poly-Gln motif, consistent with structural docking models revealing two highly scored poly-Gln- binding pockets in the ECD. As some binding is observed with BECN1 lacking the ECD, other domains of BECN1 may also interact with ATXN3. Phosphorylation at Thr-117 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy (By similarity). In response to autophagic stimuli, phosphorylated at serine residues by AMPK in an ATG14-dependent manner, and this phosphorylation is critical for maximally efficient autophagy. Polyubiquitinated by NEDD4, both with 'Lys-11'- and 'Lys-63'- linkages (By similarity). 'Lys-11'-linked poyubiquitination leads to degradation and is enhanced when the stabilizing interaction partner VPS34 is depleted (By similarity). Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes (By similarity). Polyubiquitinated at Lys-400 with 'Lys-48'-linkages (PubMed:28445460). 'Lys-48'-linked poyubiquitination of Lys-400 leads to degradation (PubMed:28445460). Deubiquitinated by ATXN3, leading to stabilization (PubMed:28445460). Ubiquitinated at Lys-435 via 'Lys-63'- linkage by the DCX(AMBRA1) complex, thereby increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). 'Lys-48'-linked ubiquitination by RNF216 leads to proteasomal degradation and autophagy inhibition (By similarity). Proteolytically processed by caspases including CASP8 and CASP3; the C-terminal fragments lack autophagy-inducing capacity and are proposed to induce apoptosis. Thus the cleavage is proposed to be an determinant to switch from autophagy to apoptosis pathways affecting cellular homeostasis including viral infections and survival of tumor cells. Death early in embryogenesis. Embryos show a severely altered autophagic response, whereas their apoptotic response to serum withdrawal or UV light is normal (PubMed:14657337). Accelerated neurodegeneration (conditional knockout in cerebellar Purkinje cells). Expanded poly-Gln tracts inhibit ATXN3-BECN1 interaction, decrease BECN1 levels and impair starvation-induced autophagy (PubMed:28445460). Belongs to the beclin family. autophagosome assembly pre-autophagosomal structure mitophagy macromitophagy angiogenesis response to hypoxia protein binding nucleus cytoplasm mitochondrion endosome autophagosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus trans-Golgi network cytosol cytoskeleton endocytosis autophagy apoptotic process cellular response to nitrogen starvation lysosome organization cell cycle mitotic metaphase plate congression aging negative regulation of cell proliferation endosome membrane response to iron(II) ion response to lead ion negative regulation of autophagy positive regulation of autophagy positive regulation of cardiac muscle hypertrophy membrane macroautophagy extrinsic component of membrane protein kinase binding dendrite cytoplasmic vesicle ubiquitin protein ligase binding response to nutrient levels mitochondrial membrane CVT pathway regulation of cytokinesis receptor catabolic process macromolecular complex response to vitamin E cellular response to amino acid starvation phosphatidylinositol 3-kinase complex, class III, type I phosphatidylinositol 3-kinase complex, class III, type II phosphatidylinositol 3-kinase complex, class III cellular response to glucose starvation response to drug protein homodimerization activity negative regulation of apoptotic process phosphatidylinositol 3-kinase binding engulfment of apoptotic cell early endosome to late endosome transport late endosome to vacuole transport phagocytic vesicle neuron development beta-amyloid metabolic process regulation of catalytic activity GTPase binding cell division defense response to virus response to other organism negative regulation of cell death cellular response to hydrogen peroxide cellular response to aluminum ion cellular response to copper ion cellular response to epidermal growth factor stimulus response to mitochondrial depolarisation positive regulation of attachment of mitotic spindle microtubules to kinetochore negative regulation of autophagosome assembly negative regulation of lysosome organization negative regulation of reactive oxygen species metabolic process positive regulation of autophagosome assembly positive regulation of intrinsic apoptotic signaling pathway uc007loj.1 uc007loj.2 uc007loj.3 
ENSMUST00000130919.2 Gm14003 ENSMUST00000130919.2 Gm14003 (from geneSymbol) ENSMUST00000130919.1 uc290acm.1 uc290acm.2 uc290acm.1 uc290acm.2 
ENSMUST00000130943.2 4930579M01Rik ENSMUST00000130943.2 4930579M01Rik (from geneSymbol) AK016330 ENSMUST00000130943.1 uc291ztp.1 uc291ztp.2 uc291ztp.1 uc291ztp.2 
ENSMUST00000130945.2 Gm12132 ENSMUST00000130945.2 Gm12132 (from geneSymbol) AK042535 ENSMUST00000130945.1 uc287xkx.1 uc287xkx.2 uc287xkx.1 uc287xkx.2 
ENSMUST00000131006.2 Gm15218 ENSMUST00000131006.2 Gm15218 (from geneSymbol) ENSMUST00000131006.1 uc288tar.1 uc288tar.2 uc288tar.1 uc288tar.2 
ENSMUST00000131007.2 Gm16131 ENSMUST00000131007.2 Gm16131 (from geneSymbol) ENSMUST00000131007.1 uc292hrp.1 uc292hrp.2 uc292hrp.1 uc292hrp.2 
ENSMUST00000131011.2 Cox7c ENSMUST00000131011.2 cytochrome c oxidase subunit 7C (from RefSeq NM_007749.3) COX7C_MOUSE Cox7c1 ENSMUST00000131011.1 NM_007749 P17665 Q3U5S7 uc007riy.1 uc007riy.2 uc007riy.3 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Energy metabolism; oxidative phosphorylation. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity). Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the cytochrome c oxidase VIIc family. cytochrome-c oxidase activity mitochondrion mitochondrial inner membrane mitochondrial electron transport, cytochrome c to oxygen membrane integral component of membrane hydrogen ion transmembrane transport uc007riy.1 uc007riy.2 uc007riy.3 
ENSMUST00000131013.2 Gm12128 ENSMUST00000131013.2 predicted gene 12128 (from RefSeq NR_131154.1) ENSMUST00000131013.1 NR_131154 uc056ykl.1 uc056ykl.2 uc056ykl.1 uc056ykl.2 
ENSMUST00000131021.2 Gm11399 ENSMUST00000131021.2 Gm11399 (from geneSymbol) ENSMUST00000131021.1 uc287wbx.1 uc287wbx.2 uc287wbx.1 uc287wbx.2 
ENSMUST00000131044.2 Gm13185 ENSMUST00000131044.2 Gm13185 (from geneSymbol) ENSMUST00000131044.1 uc289sqz.1 uc289sqz.2 uc289sqz.1 uc289sqz.2 
ENSMUST00000131064.2 4931415C17Rik ENSMUST00000131064.2 RIKEN cDNA 4931415C17 gene (from RefSeq NR_166502.1) ENSMUST00000131064.1 NR_166502 uc291ygh.1 uc291ygh.2 uc291ygh.1 uc291ygh.2 
ENSMUST00000131070.3 Ide ENSMUST00000131070.3 insulin degrading enzyme (from RefSeq NM_031156.4) ENSMUST00000131070.1 ENSMUST00000131070.2 F6RPJ9 Ide NM_031156 Q8CGB9 Q8CGB9_MOUSE uc289ruw.1 uc289ruw.2 Belongs to the peptidase M16 family. catalytic activity metalloendopeptidase activity proteolysis metal ion binding uc289ruw.1 uc289ruw.2 
ENSMUST00000131080.2 Gm44633 ENSMUST00000131080.2 Gm44633 (from geneSymbol) ENSMUST00000131080.1 uc291stl.1 uc291stl.2 uc291stl.1 uc291stl.2 
ENSMUST00000131085.2 Gm15718 ENSMUST00000131085.2 Gm15718 (from geneSymbol) ENSMUST00000131085.1 uc291wkp.1 uc291wkp.2 uc291wkp.1 uc291wkp.2 
ENSMUST00000131093.2 Gm16144 ENSMUST00000131093.2 Gm16144 (from geneSymbol) ENSMUST00000131093.1 uc292ikt.1 uc292ikt.2 uc292ikt.1 uc292ikt.2 
ENSMUST00000131099.2 Gm12436 ENSMUST00000131099.2 Gm12436 (from geneSymbol) AK048554 ENSMUST00000131099.1 uc290mqo.1 uc290mqo.2 uc290mqo.1 uc290mqo.2 
ENSMUST00000131133.3 Gm12354 ENSMUST00000131133.3 Gm12354 (from geneSymbol) ENSMUST00000131133.1 ENSMUST00000131133.2 KY467970 uc290ljo.1 uc290ljo.2 uc290ljo.3 uc290ljo.1 uc290ljo.2 uc290ljo.3 
ENSMUST00000131134.9 Col11a2 ENSMUST00000131134.9 collagen, type XI, alpha 2, transcript variant 3 (from RefSeq NM_001401301.1) COBA2_MOUSE ENSMUST00000131134.1 ENSMUST00000131134.2 ENSMUST00000131134.3 ENSMUST00000131134.4 ENSMUST00000131134.5 ENSMUST00000131134.6 ENSMUST00000131134.7 ENSMUST00000131134.8 NM_001401301 Q61432 Q64739 Q9Z1W0 uc008cbb.1 uc008cbb.2 uc008cbb.3 uc008cbb.4 uc008cbb.5 May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. Trimers composed of three different chains: alpha 1(XI), alpha 2(XI), and alpha 3(XI). Alpha 3(XI) is a post-translational modification of alpha 1(II). Alpha 1(V) can also be found instead of alpha 3(XI)=1(II) (By similarity). Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=7; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=E56789; IsoId=Q64739-2; Sequence=Displayed; Name=2; Synonyms=E5689; IsoId=Q64739-3; Sequence=VSP_007346; Name=3; Synonyms=E5789; IsoId=Q64739-4; Sequence=VSP_007345; Name=4; Synonyms=E569; IsoId=Q64739-5; Sequence=VSP_007346, VSP_007347; Name=5; Synonyms=E589; IsoId=Q64739-6; Sequence=VSP_007345, VSP_007346; Name=6; Synonyms=E59; IsoId=Q64739-7; Sequence=VSP_007345, VSP_007346, VSP_007347; Name=7; IsoId=Q64739-1; Sequence=VSP_007345, VSP_007347; The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity). Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Belongs to the fibrillar collagen family. skeletal system development osteoblast differentiation tissue homeostasis chondrocyte differentiation extracellular matrix structural constituent extracellular region collagen trimer extracellular space sensory perception of sound extracellular matrix structural constituent conferring tensile strength extracellular matrix organization collagen fibril organization extracellular matrix metal ion binding skeletal system morphogenesis cartilage development palate development soft palate development uc008cbb.1 uc008cbb.2 uc008cbb.3 uc008cbb.4 uc008cbb.5 
ENSMUST00000131138.9 Gm45692 ENSMUST00000131138.9 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; (from UniProt D3Z0A0) AK020104 D3Z0A0 D3Z0A0_MOUSE ENSMUST00000131138.1 ENSMUST00000131138.2 ENSMUST00000131138.3 ENSMUST00000131138.4 ENSMUST00000131138.5 ENSMUST00000131138.6 ENSMUST00000131138.7 ENSMUST00000131138.8 Gm45692 uc291yzr.1 uc291yzr.2 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; membrane integral component of membrane protein ubiquitination ubiquitin protein ligase activity uc291yzr.1 uc291yzr.2 
ENSMUST00000131146.2 Gm16069 ENSMUST00000131146.2 Gm16069 (from geneSymbol) ENSMUST00000131146.1 uc290gtm.1 uc290gtm.2 uc290gtm.1 uc290gtm.2 
ENSMUST00000131176.10 ENSMUSG00000121482 ENSMUST00000131176.10 ENSMUSG00000121482 (from geneSymbol) AK134020 ENSMUST00000131176.1 ENSMUST00000131176.2 ENSMUST00000131176.3 ENSMUST00000131176.4 ENSMUST00000131176.5 ENSMUST00000131176.6 ENSMUST00000131176.7 ENSMUST00000131176.8 ENSMUST00000131176.9 uc009eez.1 uc009eez.2 uc009eez.3 uc009eez.4 uc009eez.5 uc009eez.6 uc009eez.7 uc009eez.1 uc009eez.2 uc009eez.3 uc009eez.4 uc009eez.5 uc009eez.6 uc009eez.7 
ENSMUST00000131188.5 Gm13293 ENSMUST00000131188.5 Gm13293 (from geneSymbol) AK140161 ENSMUST00000131188.1 ENSMUST00000131188.2 ENSMUST00000131188.3 ENSMUST00000131188.4 uc008iid.1 uc008iid.2 uc008iid.3 uc008iid.4 uc008iid.5 uc008iid.1 uc008iid.2 uc008iid.3 uc008iid.4 uc008iid.5 
ENSMUST00000131189.2 Gm13544 ENSMUST00000131189.2 predicted gene 13544 (from RefSeq NR_040365.1) ENSMUST00000131189.1 NR_040365 uc008jsq.1 uc008jsq.2 uc008jsq.1 uc008jsq.2 
ENSMUST00000131198.2 Gm13620 ENSMUST00000131198.2 Gm13620 (from geneSymbol) ENSMUST00000131198.1 uc289wie.1 uc289wie.2 uc289wie.1 uc289wie.2 
ENSMUST00000131215.3 2610204G07Rik ENSMUST00000131215.3 2610204G07Rik (from geneSymbol) ENSMUST00000131215.1 ENSMUST00000131215.2 KY467679 uc007rtk.1 uc007rtk.2 uc007rtk.3 uc007rtk.4 uc007rtk.1 uc007rtk.2 uc007rtk.3 uc007rtk.4 
ENSMUST00000131221.3 2310058D17Rik ENSMUST00000131221.3 RIKEN cDNA 2310058D17 gene (from RefSeq NR_187688.1) ENSMUST00000131221.1 ENSMUST00000131221.2 NR_187688 uc007jcw.1 uc007jcw.2 uc007jcw.3 uc007jcw.1 uc007jcw.2 uc007jcw.3 
ENSMUST00000131222.3 Gm4285 ENSMUST00000131222.3 Gm4285 (from geneSymbol) ENSMUST00000131222.1 ENSMUST00000131222.2 uc029sly.1 uc029sly.2 uc029sly.3 uc029sly.4 uc029sly.1 uc029sly.2 uc029sly.3 uc029sly.4 
ENSMUST00000131248.2 Spaar ENSMUST00000131248.2 small regulatory polypeptide of amino acid response (from RefSeq NM_001348108.2) A0A1B0GSZ0 ENSMUST00000131248.1 NM_001348108 SPAR_MOUSE Spaar Spar uc008sqy.1 uc008sqy.2 uc008sqy.3 Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (By similarity). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (By similarity). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (PubMed:28024296). Interacts with components of the lysosomal V-ATPase complex (By similarity). Interacts with ATP6V0A1 (PubMed:28024296). Interacts with ATP6V0A2 (By similarity). Late endosome membrane ; Single-pass membrane protein Lysosome membrane ; Single-pass membrane protein Expressed in the skeletal muscle. Down-regulated in skeletal muscle upon acute injury. No visible phenotype. Mice were born at expected Mendelian ratio with no gross abnormalities. lysosome lysosomal membrane endosome membrane integral component of membrane late endosome membrane regulation of skeletal muscle tissue regeneration lysosomal proton-transporting V-type ATPase complex cellular response to amino acid stimulus negative regulation of TORC1 signaling integral component of lysosomal membrane uc008sqy.1 uc008sqy.2 uc008sqy.3 
ENSMUST00000131249.2 Gm12711 ENSMUST00000131249.2 Gm12711 (from geneSymbol) AK157062 ENSMUST00000131249.1 uc287xjt.1 uc287xjt.2 uc287xjt.1 uc287xjt.2 
ENSMUST00000131297.2 Gm13256 ENSMUST00000131297.2 Gm13256 (from geneSymbol) ENSMUST00000131297.1 uc289swn.1 uc289swn.2 uc289swn.1 uc289swn.2 
ENSMUST00000131304.3 Tex16 ENSMUST00000131304.3 Tex16 (from geneSymbol) AF285573 ENSMUST00000131304.1 ENSMUST00000131304.2 F6Z198 F6Z198_MOUSE Tex16 uc292qed.1 uc292qed.2 uc292qed.3 Prp19 complex U6 snRNA binding pre-mRNA binding U2-type catalytic step 1 spliceosome U2-type catalytic step 2 spliceosome uc292qed.1 uc292qed.2 uc292qed.3 
ENSMUST00000131309.3 Fzd3 ENSMUST00000131309.3 frizzled class receptor 3 (from RefSeq NM_021458.2) ENSMUST00000131309.1 ENSMUST00000131309.2 FZD3_MOUSE NM_021458 Q61086 uc007ujb.1 uc007ujb.2 uc007ujb.3 uc007ujb.4 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta- catenin-dependent manner. Interacts with VANGL2. Membrane; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein Cell surface Apical cell membrane ; Multi-pass membrane protein. Note=Colocalizes with FZD6 at the apical face of the cell. Expressed in the cortex, diencephalon, rostral brainstem and little or no staining is seen in the striatum or cerebellum. Expressed in both hair cells and supporting cells in the utricle, saccule, cristae and the organ of Corti in the inner ear (at protein level). Highly expressed in the CNS. In skin, it is restricted to the epidermis and to the developing hair follicle. Expressed throughout the developing central nervous system (CNS). Expressed in the cortex, diencephalon, and brainstem, with the most intense staining in the striatum and trigeminal ganglia at 18 dpc (at protein level). First detected in discrete foci in the developing epidermis of 13 days old embryos, later in the hair follicle placodes of 15 days old embryos. Expressed in the ventral and lateral margins of the spinal cord from 9.5 to 13.5 dpc, where post-crossing commissural axons project longitudinally. Expressed in superior sympathetic cervical ganglia (SCG) at 14.5 and 16.5 dpc, a stage when the SCG is comprised primarily of proliferating sympathetic neuroblasts. In 17 days embryos and 1 day old newborn, expression is limited to suprabasal keratinocytes and is not seen in pelage follicles until 3 days postpartum. In 7 days old neonatal skin, expression occurs throughout the epidermis and in the outer cell layers of hair follicles. Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. The FZ domain is involved in binding with Wnt ligands. Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. Neonate knockout mice have a curly tail, flexed lower limbs, breathe irregularly and typically die within 30 min of birth. Central nervous system (CNS) shows severe defects in the development of several major axon tracts, including: a nearly complete absence of the three early most prominent axon tracts in the brain and the ventral branch of the trigeminal nerve, absence of subcortical and striatal axons, the anterior commissure, misrouting of thalamocortical axons, a nearly complete absence of the corticospinal tract, the fasciculus retroflexus, and the mammillothalamic tract, poor fasciculation of the medial lemniscus and a disorganization of axon bundles in the reticular formation, severe defect in the asymmetric rostrocaudal orientation of dopaminergic and serotonergic axons, a large reduction or complete absence of ascending spinal axon tracts in the braistem, midbrain and thalamus, peripheral nerves defect in several motor neurons, such as in the VIIth and XIIth cranial motor nerves, the phrenic nerve, and the spinal motor nerve which failed to form connections with their respective targets and display also aberrant migration of a subpopulation of cranial neural crest cells (PubMed:12351730, PubMed:24347548, PubMed:24799694). Neonate knockout mice show fewer S-phase proliferating neuroblasts, premature cell cycle exit and enhanced apoptosis in early-stage superior cervical ganglia (SCGs), and in some cases, complete absence of sympathetic innervation of several peripheral targets (PubMed:21325504). Display also impaired rostral turning by growth cones of spinal cord commissural sensory axons (PubMed:14671310). FZD3 and FZD6 double knockout embryos have a curled tail, exhibit defects in neural tube and eyelids closure, in the orientation of hair bundles on inner-ear sensory cells and die at birth (PubMed:16495441). The following conditional knockout mice display the corresponding phenotypes: dopaminergic neuron-specific shows a defect in the orientation and growth of midbrain dopaminergic axons with an absence of striatum innervation; retinal ganglion cell (RGC)-specific displays a misrouting of a subset of optic tract axons and a lack of the medial terminal nucleus (MTN) innervation; neocortex neuron- specific displays a total absence of the posterior part of the anterior commissure and aberrant axon trajectories appearing in the external capsule; ventral telencephalon neuron-specific shows corticothalamic, thalamocortical and corticospinal tracts defect to various extent; telencephalon neuron-specific exhibits the full spectrum of axon defects seen in the classical null mutant knockout mice; cholinergic neuron-specific shows an absence of cholinergic fiber tracts passing through the striatum, a defective caudal migration of neurons of the VIIth motor nucleus and a loss of motor innervation to the face, a decrease in motor innervation of the tongue by the XIIth nerve and a complete loss of cholinergic neurons in the vomeronasal organ; oligodendrocyte neuron-specific leads to the complete spectrum of motor neuron phenotypes shown by the classical mutant knockout mice; caudal and upper thorax region-specific leads to a loss of motor innervation and an atrophy of anterior compartment muscles in the lower hindlimb by the deep peroneal nerve and a nearly absence in ascending spinal sensory axons in the brainstem, midbrain and thalamus altering the ability to transmit sensory information from the trunk and limbs to the brain in postnatal life (PubMed:24347548, PubMed:24799694). Belongs to the G-protein coupled receptor Fz/Smo family. establishment of planar polarity neuron migration neural tube closure hair follicle development positive regulation of neuroblast proliferation transmembrane signaling receptor activity G-protein coupled receptor activity protein binding cytoplasm plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway multicellular organism development nervous system development brain development cell surface membrane integral component of membrane Wnt signaling pathway apical plasma membrane lateral plasma membrane Wnt-protein binding PDZ domain binding axon dendrite midbrain development filopodium tip cell proliferation in midbrain non-canonical Wnt signaling pathway post-anal tail morphogenesis dopaminergic neuron axon guidance serotonergic neuron axon guidance inner ear morphogenesis response to drug Wnt-activated receptor activity neuronal cell body apical part of cell negative regulation of mitotic cell cycle, embryonic response to electrical stimulus canonical Wnt signaling pathway sympathetic ganglion development commissural neuron axon guidance negative regulation of execution phase of apoptosis planar cell polarity pathway involved in axon guidance presynaptic active zone uc007ujb.1 uc007ujb.2 uc007ujb.3 uc007ujb.4 
ENSMUST00000131334.2 Gm15581 ENSMUST00000131334.2 Gm15581 (from geneSymbol) BC067060 ENSMUST00000131334.1 uc291crf.1 uc291crf.2 uc291crf.1 uc291crf.2 
ENSMUST00000131351.8 Nkapd1 ENSMUST00000131351.8 NKAP domain containing 1, transcript variant 2 (from RefSeq NM_212449.3) E9PUQ3 E9PUQ3_MOUSE ENSMUST00000131351.1 ENSMUST00000131351.2 ENSMUST00000131351.3 ENSMUST00000131351.4 ENSMUST00000131351.5 ENSMUST00000131351.6 ENSMUST00000131351.7 NM_212449 Nkapd1 uc009pjy.1 uc009pjy.2 uc009pjy.3 molecular_function cellular_component biological_process uc009pjy.1 uc009pjy.2 uc009pjy.3 
ENSMUST00000131365.4 Platr27 ENSMUST00000131365.4 Platr27 (from geneSymbol) AK019110 ENSMUST00000131365.1 ENSMUST00000131365.2 ENSMUST00000131365.3 uc290cbx.1 uc290cbx.2 uc290cbx.3 uc290cbx.4 uc290cbx.1 uc290cbx.2 uc290cbx.3 uc290cbx.4 
ENSMUST00000131374.8 Rps15a ENSMUST00000131374.8 ribosomal protein S15A (from RefSeq NM_170669.2) ENSMUST00000131374.1 ENSMUST00000131374.2 ENSMUST00000131374.3 ENSMUST00000131374.4 ENSMUST00000131374.5 ENSMUST00000131374.6 ENSMUST00000131374.7 NM_170669 Q5M9M4 Q5M9M4_MOUSE Rps15a uc009jjn.1 uc009jjn.2 uc009jjn.3 uc009jjn.4 Cytoplasm Nucleus, nucleolus Belongs to the universal ribosomal protein uS8 family. structural constituent of ribosome cytoplasm ribosome translation positive regulation of cell proliferation response to virus cytosolic small ribosomal subunit positive regulation of cell cycle uc009jjn.1 uc009jjn.2 uc009jjn.3 uc009jjn.4 
ENSMUST00000131379.4 Zscan4c ENSMUST00000131379.4 zinc finger and SCAN domain containing 4C (from RefSeq NM_001013765.2) ENSMUST00000131379.1 ENSMUST00000131379.2 ENSMUST00000131379.3 Gm397 NM_001013765 Q80VJ6 ZSC4C_MOUSE uc009fdl.1 uc009fdl.2 Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells. Nucleus romosome, telomere Embryonic stem (ES) cell-specific. Expressed in only 5% of ES cells at a given time, but nearly all ES cells express it at least once during 9 passages. Transcriptionally regulated by ZSCAN10. chromosome, telomeric region nuclear chromosome, telomeric region nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus chromosome cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter telomere maintenance via telomere lengthening negative regulation of mitotic recombination metal ion binding stem cell differentiation uc009fdl.1 uc009fdl.2 
ENSMUST00000131383.3 4930538E20Rik ENSMUST00000131383.3 RIKEN cDNA 4930538E20 gene, transcript variant 1 (from RefSeq NR_167718.1) ENSMUST00000131383.1 ENSMUST00000131383.2 NR_167718 uc007ifx.1 uc007ifx.2 uc007ifx.3 uc007ifx.1 uc007ifx.2 uc007ifx.3 
ENSMUST00000131384.3 Grwd1 ENSMUST00000131384.3 Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness. (from UniProt Q810D6) A301 AB001539 ENSMUST00000131384.1 ENSMUST00000131384.2 G3UVT6 GRWD1_MOUSE Q810D6 Q922H3 uc009gxk.1 uc009gxk.2 uc009gxk.3 Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness. Interacts with METTL18. Interacts with CDT1; origin binding of GRWD1 is dependent on CDT1. Interacts with CDC6; origin binding of GRWD1 is dependent on CDC6. Binds to histone H2A-H2B and H3-H4 complexes. Nucleus, nucleolus Nucleus Chromosome Note=Present in the nucleus throughout interphase and is detached from chromatin at the onset of mitosis and rebinds at telophase when the pre-replication complexes (pre-RC) is formed (By similarity). chromatin binding DNA replication origin binding nucleus chromosome nucleolus cytosol DNA replication nucleosome assembly nucleosome disassembly macromolecular complex histone binding uc009gxk.1 uc009gxk.2 uc009gxk.3 
ENSMUST00000131387.3 Gm15963 ENSMUST00000131387.3 Gm15963 (from geneSymbol) ENSMUST00000131387.1 ENSMUST00000131387.2 uc287uev.1 uc287uev.2 uc287uev.1 uc287uev.2 
ENSMUST00000131401.2 Gm14243 ENSMUST00000131401.2 Gm14243 (from geneSymbol) AY512933 ENSMUST00000131401.1 uc290cgk.1 uc290cgk.2 uc290cgk.1 uc290cgk.2 
ENSMUST00000131421.2 Gm15334 ENSMUST00000131421.2 Gm15334 (from geneSymbol) ENSMUST00000131421.1 uc289oxn.1 uc289oxn.2 uc289oxn.1 uc289oxn.2 
ENSMUST00000131422.8 Dna2 ENSMUST00000131422.8 DNA replication helicase/nuclease 2, transcript variant 2 (from RefSeq NR_152862.1) DNA2_MOUSE Dna2l ENSMUST00000131422.1 ENSMUST00000131422.2 ENSMUST00000131422.3 ENSMUST00000131422.4 ENSMUST00000131422.5 ENSMUST00000131422.6 ENSMUST00000131422.7 Kiaa0083 NR_152862 Q14BM9 Q6ZQJ5 Q8BSZ0 Q8R3J3 uc007fjj.1 uc007fjj.2 uc007fjj.3 uc007fjj.4 Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)- dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Interacts with BLM and WDHD1. Q6ZQJ5; P70371: Terf1; NbExp=4; IntAct=EBI-6919222, EBI-6919183; Q6ZQJ5; O35144: Terf2; NbExp=4; IntAct=EBI-6919222, EBI-6919263; Nucleus Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZQJ5-1; Sequence=Displayed; Name=2; IsoId=Q6ZQJ5-2; Sequence=VSP_021872, VSP_021873; Acetylated by EP300, leading to stimulate the 5'-3' endonuclease, the 5'-3' helicase and DNA-dependent ATPase activities, possibly by increasing DNA substrate affinity. Belongs to the DNA2/NAM7 helicase family. Sequence=BAC97861.1; Type=Erroneous initiation; Evidence=; DNA replication checkpoint nucleotide binding telomere maintenance DNA double-strand break processing nuclear chromosome, telomeric region DNA binding DNA helicase activity RNA binding catalytic activity helicase activity nuclease activity endonuclease activity protein binding ATP binding nucleus cytoplasm mitochondrion gamma DNA polymerase complex DNA replication mitochondrial DNA replication DNA repair base-excision repair cellular response to DNA damage stimulus metabolic process hydrolase activity site-specific endodeoxyribonuclease activity, specific for altered base 5'-flap endonuclease activity single-stranded DNA-dependent ATP-dependent DNA helicase activity DNA duplex unwinding DNA replication, Okazaki fragment processing mitochondrial nucleoid DNA replication, removal of RNA primer 5'-3' DNA helicase activity mitochondrial DNA repair positive regulation of DNA replication metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding replication fork reversal nucleic acid phosphodiester bond hydrolysis mitotic telomere maintenance via semi-conservative replication uc007fjj.1 uc007fjj.2 uc007fjj.3 uc007fjj.4 
ENSMUST00000131423.8 Abcc12 ENSMUST00000131423.8 Probable transporter, its substrate specificity is unknown. (from UniProt Q80WJ6) AF502146 B2RRF4 ENSMUST00000131423.1 ENSMUST00000131423.2 ENSMUST00000131423.3 ENSMUST00000131423.4 ENSMUST00000131423.5 ENSMUST00000131423.6 ENSMUST00000131423.7 MRP9_MOUSE Mrp9 Q80WJ2 Q80WJ3 Q80WJ6 Q8C0P3 uc009mqk.1 uc009mqk.2 uc009mqk.3 Probable transporter, its substrate specificity is unknown. Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Localizes to the midpiece of the sperm tail. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80WJ6-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q80WJ6-2; Sequence=VSP_021093, VSP_021094; Name=3; Synonyms=A; IsoId=Q80WJ6-3; Sequence=VSP_021097, VSP_021098; Name=4; IsoId=Q80WJ6-4; Sequence=VSP_021095, VSP_021096; Widely expressed at low level (PubMed:12801629, PubMed:16141072, PubMed:17472575). Highly expressed in testis by Sertoli cells and Leydig cells (PubMed:12801629, PubMed:16141072). Detected in testicular germ cells and sperm (at protein level) (PubMed:17472575). First detected at 3 weeks of age IN the pachytene spermatocytes. During germ cell differentiation in the adult testis, pachytene spermatocytes in stage VI of the epithelial cycle are the first germ cells to show MRP9 expression. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Does not transport any of the organic anions transported by the other multidrug resistance-associated proteins (MRPs) in vesicular transport assays, nor does it confer resistance to cytotoxic agents in intact cell assays. nucleotide binding ATP binding mitochondrion membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances transmembrane transport uc009mqk.1 uc009mqk.2 uc009mqk.3 
ENSMUST00000131441.2 9130204K15Rik ENSMUST00000131441.2 9130204K15Rik (from geneSymbol) AK078931 ENSMUST00000131441.1 uc288arc.1 uc288arc.2 uc288arc.1 uc288arc.2 
ENSMUST00000131446.8 Arfip2 ENSMUST00000131446.8 ADP-ribosylation factor interacting protein 2 (from RefSeq NM_029802.4) ARFP2_MOUSE Arfip2 ENSMUST00000131446.1 ENSMUST00000131446.2 ENSMUST00000131446.3 ENSMUST00000131446.4 ENSMUST00000131446.5 ENSMUST00000131446.6 ENSMUST00000131446.7 NM_029802 Q3U3G6 Q8K221 Q9D7M3 uc009iyr.1 uc009iyr.2 uc009iyr.3 uc009iyr.4 Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4- kinase beta (PI4KB) to the autophagosome initiation site. Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG. Forms homodimers or heterodimers with ARFIP1. Interacts with RAC1. Specifically binds to GTP-bound ARF1 and ARF6, but binds to RAC1.GTP and RAC1.GDP with similar affinities. Interacts with ARL1. Interacts (via N-terminus) with IKBKB and IKBKG; these interactions inhibit activation of NF-kappa-B. Golgi apparatus Golgi apparatus, trans-Golgi network membrane ruffle protein binding phospholipid binding cytoplasm cell cortex intracellular protein transport protein domain specific binding actin cytoskeleton organization GTP-dependent protein binding trans-Golgi network membrane identical protein binding phosphatidylinositol-4-phosphate binding uc009iyr.1 uc009iyr.2 uc009iyr.3 uc009iyr.4 
ENSMUST00000131475.2 Ggct ENSMUST00000131475.2 gamma-glutamyl cyclotransferase (from RefSeq NM_026637.3) ENSMUST00000131475.1 GGCT_MOUSE NM_026637 Q3URJ2 Q66JQ5 Q9D7X8 uc009cah.1 uc009cah.2 uc009cah.3 Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Reaction=an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid; Xref=Rhea:RHEA:20505, ChEBI:CHEBI:58402, ChEBI:CHEBI:59869, ChEBI:CHEBI:71304; EC=4.3.2.9; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20506; Evidence=; Homodimer. Belongs to the gamma-glutamylcyclotransferase family. release of cytochrome c from mitochondria gamma-glutamylcyclotransferase activity cytosol lyase activity protein homodimerization activity uc009cah.1 uc009cah.2 uc009cah.3 
ENSMUST00000131498.2 A830012C17Rik ENSMUST00000131498.2 A830012C17Rik (from geneSymbol) AK043612 ENSMUST00000131498.1 uc008rxb.1 uc008rxb.2 uc008rxb.1 uc008rxb.2 
ENSMUST00000131501.8 D030028A08Rik ENSMUST00000131501.8 D030028A08Rik (from geneSymbol) AK029743 ENSMUST00000131501.1 ENSMUST00000131501.2 ENSMUST00000131501.3 ENSMUST00000131501.4 ENSMUST00000131501.5 ENSMUST00000131501.6 ENSMUST00000131501.7 uc288bst.1 uc288bst.2 uc288bst.1 uc288bst.2 
ENSMUST00000131514.3 Gm14019 ENSMUST00000131514.3 Gm14019 (from geneSymbol) ENSMUST00000131514.1 ENSMUST00000131514.2 uc289zzi.1 uc289zzi.2 uc289zzi.3 uc289zzi.1 uc289zzi.2 uc289zzi.3 
ENSMUST00000131516.9 0610025J13Rik ENSMUST00000131516.9 0610025J13Rik (from geneSymbol) AK002663 ENSMUST00000131516.1 ENSMUST00000131516.2 ENSMUST00000131516.3 ENSMUST00000131516.4 ENSMUST00000131516.5 ENSMUST00000131516.6 ENSMUST00000131516.7 ENSMUST00000131516.8 uc008ttz.1 uc008ttz.2 uc008ttz.3 uc008ttz.4 uc008ttz.1 uc008ttz.2 uc008ttz.3 uc008ttz.4 
ENSMUST00000131539.2 Gm11377 ENSMUST00000131539.2 Gm11377 (from geneSymbol) AK085428 ENSMUST00000131539.1 uc007pzk.1 uc007pzk.2 uc007pzk.3 uc007pzk.1 uc007pzk.2 uc007pzk.3 
ENSMUST00000131570.3 Gm12043 ENSMUST00000131570.3 Gm12043 (from geneSymbol) AK038605 ENSMUST00000131570.1 ENSMUST00000131570.2 uc007idu.1 uc007idu.2 uc007idu.3 uc007idu.1 uc007idu.2 uc007idu.3 
ENSMUST00000131588.3 C79798 ENSMUST00000131588.3 C79798 (from geneSymbol) AK138624 ENSMUST00000131588.1 ENSMUST00000131588.2 uc008jij.1 uc008jij.2 uc008jij.1 uc008jij.2 
ENSMUST00000131615.9 Fign ENSMUST00000131615.9 fidgetin, transcript variant 1 (from RefSeq NM_021716.5) ENSMUST00000131615.1 ENSMUST00000131615.2 ENSMUST00000131615.3 ENSMUST00000131615.4 ENSMUST00000131615.5 ENSMUST00000131615.6 ENSMUST00000131615.7 ENSMUST00000131615.8 FIGN_MOUSE NM_021716 Q3TPB0 Q3UP57 Q6PCM0 Q9ERZ6 uc008jvv.1 uc008jvv.2 uc008jvv.3 uc008jvv.4 uc008jvv.5 ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity). Interacts with AKAP8 (via C-terminus). Q9ERZ6; Q9DBR0: Akap8; NbExp=4; IntAct=EBI-11111349, EBI-4285802; Nucleus matrix Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ERZ6-1; Sequence=Displayed; Name=2; IsoId=Q9ERZ6-2; Sequence=VSP_020731; Widely expressed. Expression begins in the embryo at 8.5 dpc. Oocyst, optic cup and pelvic anlage show strongest expression. At 10.5 dpc, expression concentrated in epithelial cells of the dorso-lateral, posterior and anterior otocyst wall. Expression in the eye is found fairly evenly throughout the retinal neural epithelium, with some enrichment in the inner retina where cells begin their differentiation to form retinal ganglion cells. Some expression is seen in the lens pit and in the cell layer that will become the pigment epithelium. At 11.5 dpc, when the superior semicircular canal has begun to form from the posterior otocyst, much of the expression is concentrated there, although there is also expression in the part of the otocyst that will form the lateral or horizontal canal. Strong expression was also seen in the acoustic ganglia and cochlea. In the eye the expression pattern is similar to that found in 10.5 dpc except that expression is concentrated in the retinal ganglion layer. As the lens vesicle forms and matures at 13 dpc, expression is also seen in the anterior wall of the lens, but persists throughout the neural retina, especially in the peripheral retina where cells are still differentiating. Note=Defects in Fign are characterized by a side-to-side head- shaking and circling behavior, due to reduced or absent semicircular canals. Diseased mice also have small eyes, associated with cell-cycle delay and insufficient growth of the retinal neural epithelium, and lower penetrance skeletal abnormalities, including pelvic girdle dysgenesis, skull bone fusions and polydactyly. FIGN and AKAP8 double mutant mice die soon after birth due to cleft palate. Belongs to the AAA ATPase family. nucleotide binding protein binding ATP binding nucleus cytoplasm microtubule organizing center cytoskeleton microtubule cell cycle protein C-terminus binding microtubule-severing ATPase activity regulation of double-strand break repair via homologous recombination nuclear matrix ATPase activity cytoplasmic microtubule organization microtubule severing cell division uc008jvv.1 uc008jvv.2 uc008jvv.3 uc008jvv.4 uc008jvv.5 
ENSMUST00000131619.3 Gm16127 ENSMUST00000131619.3 Gm16127 (from geneSymbol) ENSMUST00000131619.1 ENSMUST00000131619.2 uc292jsh.1 uc292jsh.2 uc292jsh.1 uc292jsh.2 
ENSMUST00000131634.2 Gm13783 ENSMUST00000131634.2 Gm13783 (from geneSymbol) AK038769 ENSMUST00000131634.1 uc289yjp.1 uc289yjp.2 uc289yjp.1 uc289yjp.2 
ENSMUST00000131642.2 Gm12319 ENSMUST00000131642.2 Gm12319 (from geneSymbol) ENSMUST00000131642.1 KY467596 uc287zse.1 uc287zse.2 uc287zse.1 uc287zse.2 
ENSMUST00000131656.2 Coa7 ENSMUST00000131656.2 cytochrome c oxidase assembly factor 7 (from RefSeq NM_027250.4) COA7_MOUSE ENSMUST00000131656.1 NM_027250 Q921H9 Selrc1 uc008uaz.1 uc008uaz.2 uc008uaz.3 Required for assembly of mitochondrial respiratory chain complex I and complex IV. Interacts with CHCHD4/MIA40 through transient intermolecular disulfide bonds. Mitochondrion intermembrane space Note=The import in the mitochondrion intermembrane space is mediated by CHCHD4/MIA40. Belongs to the hcp beta-lactamase family. molecular_function nucleus mitochondrion mitochondrial intermembrane space biological_process uc008uaz.1 uc008uaz.2 uc008uaz.3 
ENSMUST00000131675.2 Gm11782 ENSMUST00000131675.2 Gm11782 (from geneSymbol) AK030024 ENSMUST00000131675.1 uc290laa.1 uc290laa.2 uc290laa.1 uc290laa.2 
ENSMUST00000131687.4 2410003L11Rik ENSMUST00000131687.4 2410003L11Rik (from geneSymbol) AK010368 ENSMUST00000131687.1 ENSMUST00000131687.2 ENSMUST00000131687.3 uc007lef.1 uc007lef.2 uc007lef.3 uc007lef.4 uc007lef.1 uc007lef.2 uc007lef.3 uc007lef.4 
ENSMUST00000131690.3 Gm14616 ENSMUST00000131690.3 predicted gene 14616 (from RefSeq NR_166457.1) ENSMUST00000131690.1 ENSMUST00000131690.2 NR_166457 uc290dbi.1 uc290dbi.2 uc290dbi.3 uc290dbi.1 uc290dbi.2 uc290dbi.3 
ENSMUST00000131722.9 Zfp563 ENSMUST00000131722.9 zinc finger protein 563 (from RefSeq NM_001024950.2) B8JJZ9 B8JJZ9_MOUSE ENSMUST00000131722.1 ENSMUST00000131722.2 ENSMUST00000131722.3 ENSMUST00000131722.4 ENSMUST00000131722.5 ENSMUST00000131722.6 ENSMUST00000131722.7 ENSMUST00000131722.8 NM_001024950 Zfp563 uc008bya.1 uc008bya.2 uc008bya.3 uc008bya.4 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008bya.1 uc008bya.2 uc008bya.3 uc008bya.4 
ENSMUST00000131728.4 Pa2g4 ENSMUST00000131728.4 Belongs to the peptidase M24 family. (from UniProt Q3TGU7) AK144645 D3YVH7 ENSMUST00000131728.1 ENSMUST00000131728.2 ENSMUST00000131728.3 Pa2g4 Q3TGU7 Q3TGU7_MOUSE uc287vup.1 uc287vup.2 Belongs to the peptidase M24 family. nucleolus cytoplasm negative regulation of apoptotic process positive regulation of cell differentiation uc287vup.1 uc287vup.2 
ENSMUST00000131733.2 Gm12981 ENSMUST00000131733.2 Gm12981 (from geneSymbol) ENSMUST00000131733.1 KY468020 uc057lki.1 uc057lki.2 uc057lki.1 uc057lki.2 
ENSMUST00000131740.8 Tspan32os ENSMUST00000131740.8 Tspan32os (from geneSymbol) AK039657 ENSMUST00000131740.1 ENSMUST00000131740.2 ENSMUST00000131740.3 ENSMUST00000131740.4 ENSMUST00000131740.5 ENSMUST00000131740.6 ENSMUST00000131740.7 uc009kok.1 uc009kok.2 uc009kok.1 uc009kok.2 
ENSMUST00000131780.8 Slc66a2 ENSMUST00000131780.8 Membrane ; Multi-pass membrane protein (from UniProt Q80XM9) BC043686 ENSMUST00000131780.1 ENSMUST00000131780.2 ENSMUST00000131780.3 ENSMUST00000131780.4 ENSMUST00000131780.5 ENSMUST00000131780.6 ENSMUST00000131780.7 Pqlc1 Q3U6E6 Q80XM9 Q9CYA7 Q9D2D3 Q9D2V1 Q9D7G6 S66A2_MOUSE uc008fsu.1 uc008fsu.2 uc008fsu.3 uc008fsu.4 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80XM9-1; Sequence=Displayed; Name=2; IsoId=Q80XM9-2; Sequence=VSP_024146; Name=3; IsoId=Q80XM9-3; Sequence=VSP_024146, VSP_024149; Name=4; IsoId=Q80XM9-4; Sequence=VSP_024147, VSP_024148; Sequence=BAB31886.1; Type=Frameshift; Evidence=; molecular_function cytosol membrane integral component of membrane retrograde transport, endosome to Golgi phospholipid translocation uc008fsu.1 uc008fsu.2 uc008fsu.3 uc008fsu.4 
ENSMUST00000131787.4 2410006H16Rik ENSMUST00000131787.4 2410006H16Rik (from geneSymbol) ENSMUST00000131787.1 ENSMUST00000131787.2 ENSMUST00000131787.3 KY467467 uc007jjk.1 uc007jjk.2 uc007jjk.3 uc007jjk.4 uc007jjk.5 uc007jjk.1 uc007jjk.2 uc007jjk.3 uc007jjk.4 uc007jjk.5 
ENSMUST00000131790.3 Saxo1os ENSMUST00000131790.3 Saxo1os (from geneSymbol) AK015482 ENSMUST00000131790.1 ENSMUST00000131790.2 uc008tlv.1 uc008tlv.2 uc008tlv.3 uc008tlv.4 uc008tlv.5 uc008tlv.1 uc008tlv.2 uc008tlv.3 uc008tlv.4 uc008tlv.5 
ENSMUST00000131801.2 Gm14252 ENSMUST00000131801.2 Gm14252 (from geneSymbol) AK139677 ENSMUST00000131801.1 uc290bxp.1 uc290bxp.2 uc290bxp.1 uc290bxp.2 
ENSMUST00000131824.8 Ralgapa2 ENSMUST00000131824.8 Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. (from UniProt A3KGS3) A3KGS3 A3KGS5 B7ZCU9 BC053994 ENSMUST00000131824.1 ENSMUST00000131824.2 ENSMUST00000131824.3 ENSMUST00000131824.4 ENSMUST00000131824.5 ENSMUST00000131824.6 ENSMUST00000131824.7 Kiaa1272 Q3TZD9 Q4VA60 Q69ZM8 Q7TQL4 Q8BYP2 RGPA2_MOUSE uc290bcm.1 uc290bcm.2 Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. Component of the heterodimeric RalGAP2 complex with RALGAPB. Heterodimerization is required for activity (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A3KGS3-1; Sequence=Displayed; Name=2; IsoId=A3KGS3-2; Sequence=VSP_025251, VSP_025252; Abundantly expressed in testis, pancreas, lung, thymus, brown fat, and white fat. Sequence=BAC30146.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC30146.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact leading to erroneous C-terminus.; Evidence=; Sequence=CAM46007.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM46125.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM46200.1; Type=Erroneous gene model prediction; Evidence=; GTPase activator activity nucleus cytoplasm cytosol plasma membrane Ral protein signal transduction regulation of protein localization positive regulation of GTPase activity protein heterodimerization activity regulation of small GTPase mediated signal transduction regulation of exocyst localization activation of GTPase activity uc290bcm.1 uc290bcm.2 
ENSMUST00000131851.2 Gm12116 ENSMUST00000131851.2 Gm12116 (from geneSymbol) AK029182 ENSMUST00000131851.1 uc287xiq.1 uc287xiq.2 uc287xiq.1 uc287xiq.2 
ENSMUST00000131896.2 Srrm3os ENSMUST00000131896.2 Srrm3os (from geneSymbol) AK015859 ENSMUST00000131896.1 uc291aqd.1 uc291aqd.2 uc291aqd.1 uc291aqd.2 
ENSMUST00000131908.2 Gm14228 ENSMUST00000131908.2 Gm14228 (from geneSymbol) AK080351 ENSMUST00000131908.1 uc008nrm.1 uc008nrm.2 uc008nrm.1 uc008nrm.2 
ENSMUST00000131961.3 Gm14010 ENSMUST00000131961.3 Gm14010 (from geneSymbol) ENSMUST00000131961.1 ENSMUST00000131961.2 uc290ahv.1 uc290ahv.2 uc290ahv.3 uc290ahv.1 uc290ahv.2 uc290ahv.3 
ENSMUST00000131968.2 Gm48551 ENSMUST00000131968.2 Gm48551 (from geneSymbol) AK080664 ENSMUST00000131968.1 F6TY47 F6TY47_MOUSE Gm48551 uc287tix.1 uc287tix.2 membrane integral component of membrane uc287tix.1 uc287tix.2 
ENSMUST00000131996.8 Rgs17 ENSMUST00000131996.8 regulator of G-protein signaling 17, transcript variant 2 (from RefSeq NM_019958.4) ENSMUST00000131996.1 ENSMUST00000131996.2 ENSMUST00000131996.3 ENSMUST00000131996.4 ENSMUST00000131996.5 ENSMUST00000131996.6 ENSMUST00000131996.7 NM_019958 Q543T9 Q9QZB0 RGS17_MOUSE Rgsz2 uc007egg.1 uc007egg.2 uc007egg.3 uc007egg.4 uc007egg.5 Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. Interacts with GNAI1 and GNAQ (By similarity). Interacts with GNAZ and GNAI2 (PubMed:15827571, PubMed:16900103). Interacts with OPRM1 (PubMed:15827571). Forms a complex with mu-opioid receptors and G(alpha)z/i2 subunits, including GNAZ and GNAI2; the formation of this complex results in mu-opioid receptor desensitization (PubMed:15827571). Interacts with HINT1 (PubMed:31088288). Membrane napse, synaptosome Nucleus Cytoplasm Detected in brain (at protein level) (PubMed:15827571, PubMed:16900103). Highly expressed in the hypothalamus, periaqueductal gray matter, and pons-medulla. Lower levels in the thalamus, cortex and spinal cord. Weak expression in the striatum and cerebellum. N- and O-glycosylated in synapsomal membranes. Serine phosphorylated in synapsomal membranes. Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (PubMed:16900103). Desumoylated by HINT1 (PubMed:31088288). GTPase activator activity nucleus cytoplasm G-protein coupled receptor signaling pathway negative regulation of signal transduction membrane cell junction neuron projection positive regulation of GTPase activity synapse uc007egg.1 uc007egg.2 uc007egg.3 uc007egg.4 uc007egg.5 
ENSMUST00000132007.2 Gm12000 ENSMUST00000132007.2 predicted gene 12000 (from RefSeq NR_189028.1) ENSMUST00000132007.1 NR_189028 uc287wqq.1 uc287wqq.2 uc287wqq.1 uc287wqq.2 
ENSMUST00000132019.2 Gm15354 ENSMUST00000132019.2 Gm15354 (from geneSymbol) AK155175 ENSMUST00000132019.1 uc292ahf.1 uc292ahf.2 uc292ahf.1 uc292ahf.2 
ENSMUST00000132032.8 Cnot7 ENSMUST00000132032.8 CCR4-NOT transcription complex, subunit 7, transcript variant 2 (from RefSeq NM_001271542.1) CNOT7_MOUSE Caf1 ENSMUST00000132032.1 ENSMUST00000132032.2 ENSMUST00000132032.3 ENSMUST00000132032.4 ENSMUST00000132032.5 ENSMUST00000132032.6 ENSMUST00000132032.7 NM_001271542 Q60809 uc009lmt.1 uc009lmt.2 uc009lmt.3 uc009lmt.4 Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for miRNA- mediated mRNA deadenylation. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Note=Binds 2 divalent metal cations per subunit with RNAase activity being higher in presence of Mn(2+) than of Mg(2+) or Co(2+). ; Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8 (By similarity). In the complex, interacts directly with CNOT1 (By similarity). Interacts with AGO2 (PubMed:19716330). Interacts with TOB1; recruited by TOB1 to a ternary complex with CPEB3 which is required for mRNA deadenylation and decay (By similarity). Interacts with BTG1 (PubMed:9712883). Interacts with BTG2 (PubMed:9712883). Interacts with NANOS2 (PubMed:20133598). Interacts with ZFP36, ZFP36L1 and ZFP36L2; these interactions are inhibited in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (By similarity). Interacts with BTG4 (PubMed:27065194). Interacts with EIF4E; this interaction is increased by CNOT7 interaction with BTG4 (PubMed:27065194). Q60809; Q04211: Btg2; NbExp=2; IntAct=EBI-2104739, EBI-7847081; Q60809; O70552: Btg4; NbExp=6; IntAct=EBI-2104739, EBI-16204405; Q60809; Q8VEG6: Cnot6l; NbExp=2; IntAct=EBI-2104739, EBI-2104661; Q60809; P62324: BTG1; Xeno; NbExp=5; IntAct=EBI-2104739, EBI-742279; Q60809; P78543: BTG2; Xeno; NbExp=5; IntAct=EBI-2104739, EBI-1047576; Q60809; Q9UKZ1: CNOT11; Xeno; NbExp=3; IntAct=EBI-2104739, EBI-2562014; Q60809; P06730: EIF4E; Xeno; NbExp=2; IntAct=EBI-2104739, EBI-73440; Q60809; Q14106: TOB2; Xeno; NbExp=4; IntAct=EBI-2104739, EBI-2562000; Nucleus Cytoplasm, P-body Cytoplasm, Cytoplasmic ribonucleoprotein granule Note=NANOS2 promotes its localization to P-body (PubMed:20133598). Recruited to cytoplasmic ribonucleoprotein membraneless compartments by CAPRIN1, promoting deadenylation of mRNAs (By similarity). Expressed in embryonic stem (ES) cells. Belongs to the CAF1 family. negative regulation of transcription from RNA polymerase II promoter 3'-5'-exoribonuclease activity nuclear-transcribed mRNA poly(A) tail shortening deadenylation-dependent decapping of nuclear-transcribed mRNA P-body nucleic acid binding transcription corepressor activity RNA binding nuclease activity exonuclease activity exoribonuclease activity poly(A)-specific ribonuclease activity protein binding nucleus cytoplasm regulation of translation transcription factor binding positive regulation of cell proliferation negative regulation of cell proliferation negative regulation of gene expression nuclear body nuclear speck hydrolase activity negative regulation of translation CCR4-NOT complex CCR4-NOT core complex gene silencing by RNA cytoplasmic mRNA processing body assembly regulation of tyrosine phosphorylation of STAT protein exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay positive regulation of viral genome replication negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding defense response to virus positive regulation of nuclear-transcribed mRNA poly(A) tail shortening negative regulation of type I interferon-mediated signaling pathway positive regulation of mRNA catabolic process host cell PML body nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay uc009lmt.1 uc009lmt.2 uc009lmt.3 uc009lmt.4 
ENSMUST00000132069.2 Gm15859 ENSMUST00000132069.2 Gm15859 (from geneSymbol) ENSMUST00000132069.1 uc289cdi.1 uc289cdi.2 uc289cdi.1 uc289cdi.2 
ENSMUST00000132076.2 Gm15656 ENSMUST00000132076.2 Gm15656 (from geneSymbol) ENSMUST00000132076.1 uc292aiu.1 uc292aiu.2 uc292aiu.1 uc292aiu.2 
ENSMUST00000132097.2 Gm15520 ENSMUST00000132097.2 Gm15520 (from geneSymbol) AK077358 ENSMUST00000132097.1 uc009oqw.1 uc009oqw.2 uc009oqw.1 uc009oqw.2 
ENSMUST00000132100.2 Gm15178 ENSMUST00000132100.2 Gm15178 (from geneSymbol) ENSMUST00000132100.1 uc287jlj.1 uc287jlj.2 uc287jlj.1 uc287jlj.2 
ENSMUST00000132101.8 Gm3985 ENSMUST00000132101.8 Gm3985 (from geneSymbol) AK158352 ENSMUST00000132101.1 ENSMUST00000132101.2 ENSMUST00000132101.3 ENSMUST00000132101.4 ENSMUST00000132101.5 ENSMUST00000132101.6 ENSMUST00000132101.7 uc012gbz.1 uc012gbz.2 uc012gbz.3 uc012gbz.1 uc012gbz.2 uc012gbz.3 
ENSMUST00000132119.2 Gm5475 ENSMUST00000132119.2 Gm5475 (from geneSymbol) AK142522 ENSMUST00000132119.1 uc289bjz.1 uc289bjz.2 uc289bjz.1 uc289bjz.2 
ENSMUST00000132121.8 Immp2l ENSMUST00000132121.8 IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) (from RefSeq NM_053122.5) ENSMUST00000132121.1 ENSMUST00000132121.2 ENSMUST00000132121.3 ENSMUST00000132121.4 ENSMUST00000132121.5 ENSMUST00000132121.6 ENSMUST00000132121.7 IMP2L_MOUSE NM_053122 Q3TTI2 Q8BPT6 Q925F6 uc029rsc.1 uc029rsc.2 uc029rsc.3 Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity). Heterodimer of 2 subunits, IMMPL1 and IMMPL2. Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the peptidase S26 family. IMP2 subfamily. ovarian follicle development mitochondrion mitochondrial inner membrane signal peptide processing proteolysis protein processing involved in protein targeting to mitochondrion superoxide metabolic process cellular response to DNA damage stimulus spermatogenesis brain development blood circulation protein localization peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity respiratory electron transport chain ovulation mitochondrial respiratory chain complex assembly mitochondrial inner membrane peptidase complex cerebellum vasculature development uc029rsc.1 uc029rsc.2 uc029rsc.3 
ENSMUST00000132130.3 Gm13838 ENSMUST00000132130.3 Gm13838 (from geneSymbol) ENSMUST00000132130.1 ENSMUST00000132130.2 uc290ywv.1 uc290ywv.2 uc290ywv.3 uc290ywv.1 uc290ywv.2 uc290ywv.3 
ENSMUST00000132140.2 Gm12594 ENSMUST00000132140.2 Gm12594 (from geneSymbol) ENSMUST00000132140.1 uc290myv.1 uc290myv.2 uc290myv.1 uc290myv.2 
ENSMUST00000132151.8 Fsd1l ENSMUST00000132151.8 fibronectin type III and SPRY domain containing 1-like, transcript variant 4 (from RefSeq NM_001369182.1) Ccdc10 Csdufd1 ENSMUST00000132151.1 ENSMUST00000132151.2 ENSMUST00000132151.3 ENSMUST00000132151.4 ENSMUST00000132151.5 ENSMUST00000132151.6 ENSMUST00000132151.7 FSD1L_MOUSE Fsd1nl NM_001369182 Q3USW7 Q8BYN5 uc012deh.1 uc012deh.2 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BYN5-1; Sequence=Displayed; Name=2; IsoId=Q8BYN5-2; Sequence=VSP_039648; Name=3; IsoId=Q8BYN5-3; Sequence=VSP_039649, VSP_039650; [Isoform 3]: Due to intron retention. molecular_function cellular_component biological_process uc012deh.1 uc012deh.2 
ENSMUST00000132154.2 4930432L08Rik ENSMUST00000132154.2 RIKEN cDNA 4930432L08 gene (from RefSeq NR_152115.1) ENSMUST00000132154.1 NR_152115 uc290wnd.1 uc290wnd.2 uc290wnd.1 uc290wnd.2 
ENSMUST00000132184.2 Gm16153 ENSMUST00000132184.2 Gm16153 (from geneSymbol) ENSMUST00000132184.1 uc287pgr.1 uc287pgr.2 uc287pgr.1 uc287pgr.2 
ENSMUST00000132211.2 Gm13187 ENSMUST00000132211.2 Gm13187 (from geneSymbol) AK045137 ENSMUST00000132211.1 uc289srp.1 uc289srp.2 uc289srp.1 uc289srp.2 
ENSMUST00000132214.8 Ccdc38 ENSMUST00000132214.8 coiled-coil domain containing 38, transcript variant 2 (from RefSeq NM_001359749.1) CCD38_MOUSE ENSMUST00000132214.1 ENSMUST00000132214.2 ENSMUST00000132214.3 ENSMUST00000132214.4 ENSMUST00000132214.5 ENSMUST00000132214.6 ENSMUST00000132214.7 NM_001359749 Q8CDD6 Q8CDE1 Q8CDN8 uc007guv.1 uc007guv.2 uc007guv.3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CDN8-1; Sequence=Displayed; Name=2; IsoId=Q8CDN8-2; Sequence=VSP_018331, VSP_018332; molecular_function cytoplasm centrosome microtubule organizing center cytoskeleton biological_process uc007guv.1 uc007guv.2 uc007guv.3 
ENSMUST00000132219.2 Gm11851 ENSMUST00000132219.2 Gm11851 (from geneSymbol) ENSMUST00000132219.1 uc290liq.1 uc290liq.2 uc290liq.1 uc290liq.2 
ENSMUST00000132221.3 Tmem275 ENSMUST00000132221.3 transmembrane protein 275 (from RefSeq NM_001357060.1) A0A0U1RQ45 ENSMUST00000132221.1 ENSMUST00000132221.2 NM_001357060 TM275_MOUSE Tmem275 uc057lju.1 uc057lju.2 uc057lju.3 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc057lju.1 uc057lju.2 uc057lju.3 
ENSMUST00000132223.2 Gm15990 ENSMUST00000132223.2 Gm15990 (from geneSymbol) AK133288 ENSMUST00000132223.1 uc287ttp.1 uc287ttp.2 uc287ttp.1 uc287ttp.2 
ENSMUST00000132247.2 Gm13063 ENSMUST00000132247.2 Gm13063 (from geneSymbol) ENSMUST00000132247.1 uc290qjo.1 uc290qjo.2 uc290qjo.1 uc290qjo.2 
ENSMUST00000132250.8 Gm10653 ENSMUST00000132250.8 predicted gene 10653 (from RefSeq NR_003965.2) ENSMUST00000132250.1 ENSMUST00000132250.2 ENSMUST00000132250.3 ENSMUST00000132250.4 ENSMUST00000132250.5 ENSMUST00000132250.6 ENSMUST00000132250.7 NR_003965 uc012gus.1 uc012gus.2 uc012gus.1 uc012gus.2 
ENSMUST00000132253.5 Ost4 ENSMUST00000132253.5 oligosaccharyltransferase complex subunit 4 (non-catalytic), transcript variant 1 (from RefSeq NM_024460.4) ENSMUST00000132253.1 ENSMUST00000132253.2 ENSMUST00000132253.3 ENSMUST00000132253.4 NM_024460 OST4_MOUSE Ost4 Q99LX8 uc008wwk.1 uc008wwk.2 uc008wwk.3 uc008wwk.4 Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes. Protein modification; protein glycosylation. Component of the oligosaccharyltransferase (OST) complex (By similarity). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (By similarity). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Endoplasmic reticulum Endoplasmic reticulum membrane; Single- pass type III membrane protein Belongs to the OST4 family. molecular_function cellular_component endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation biological_process oligosaccharyltransferase complex membrane integral component of membrane protein N-linked glycosylation via asparagine uc008wwk.1 uc008wwk.2 uc008wwk.3 uc008wwk.4 
ENSMUST00000132264.2 Sap30bpos ENSMUST00000132264.2 Sap30bpos (from geneSymbol) AK038665 ENSMUST00000132264.1 uc007mje.1 uc007mje.2 uc007mje.1 uc007mje.2 
ENSMUST00000132267.3 Gm15559 ENSMUST00000132267.3 predicted gene 15559 (from RefSeq NR_152254.1) ENSMUST00000132267.1 ENSMUST00000132267.2 NR_152254 uc008yrl.1 uc008yrl.2 uc008yrl.3 uc008yrl.4 uc008yrl.1 uc008yrl.2 uc008yrl.3 uc008yrl.4 
ENSMUST00000132298.2 Gm20708 ENSMUST00000132298.2 Gm20708 (from geneSymbol) AK004030 ENSMUST00000132298.1 Gm20708 H3BKF4 H3BKF4_MOUSE uc007mny.1 uc007mny.2 uc007mny.3 uc007mny.4 synaptic vesicle membrane neuromuscular junction uc007mny.1 uc007mny.2 uc007mny.3 uc007mny.4 
ENSMUST00000132321.3 4930579D09Rik ENSMUST00000132321.3 4930579D09Rik (from geneSymbol) AK016315 ENSMUST00000132321.1 ENSMUST00000132321.2 uc291kcq.1 uc291kcq.2 uc291kcq.3 uc291kcq.1 uc291kcq.2 uc291kcq.3 
ENSMUST00000132323.2 Gm12249 ENSMUST00000132323.2 Gm12249 (from geneSymbol) AK131837 ENSMUST00000132323.1 uc287yij.1 uc287yij.2 uc287yij.1 uc287yij.2 
ENSMUST00000132332.2 Gm13667 ENSMUST00000132332.2 Gm13667 (from geneSymbol) ENSMUST00000132332.1 uc289wzv.1 uc289wzv.2 uc289wzv.1 uc289wzv.2 
ENSMUST00000132337.2 Gm12681 ENSMUST00000132337.2 Gm12681 (from geneSymbol) ENSMUST00000132337.1 uc290nzs.1 uc290nzs.2 uc290nzs.1 uc290nzs.2 
ENSMUST00000132353.2 Amy2a1 ENSMUST00000132353.2 Reaction=Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D- glucose units.; EC=3.2.1.1; Evidence=; (from UniProt E9PV85) AK133526 Amy2a1 E9PV85 E9PV85_MOUSE ENSMUST00000132353.1 uc290iwv.1 uc290iwv.2 Reaction=Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D- glucose units.; EC=3.2.1.1; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence=; Belongs to the glycosyl hydrolase 13 family. molecular_function catalytic activity cellular_component carbohydrate metabolic process biological_process cation binding uc290iwv.1 uc290iwv.2 
ENSMUST00000132374.9 Nkiras1 ENSMUST00000132374.9 NFKB inhibitor interacting Ras-like protein 1, transcript variant 1 (from RefSeq NM_023526.4) ENSMUST00000132374.1 ENSMUST00000132374.2 ENSMUST00000132374.3 ENSMUST00000132374.4 ENSMUST00000132374.5 ENSMUST00000132374.6 ENSMUST00000132374.7 ENSMUST00000132374.8 KBRS1_MOUSE NM_023526 Q8CEC5 Q9JKV3 uc007shs.1 uc007shs.2 uc007shs.3 uc007shs.4 Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo. Forms a complex with NFKBIB and NF-kappa-B heterodimer (p50/NFKB1 and p65/RELA). Also interacts with c-Rel (REL) (By similarity). Cytoplasm In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins. Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. nucleotide binding GTPase activity GTP binding cellular_component cytoplasm I-kappaB kinase/NF-kappaB signaling biological_process uc007shs.1 uc007shs.2 uc007shs.3 uc007shs.4 
ENSMUST00000132397.2 Gm20517 ENSMUST00000132397.2 predicted gene 20517, transcript variant 2 (from RefSeq NR_157366.1) ENSMUST00000132397.1 G3UVU6 G3UVU6_MOUSE Gm20517 MED20 NR_157366 uc289lqo.1 uc289lqo.2 This locus represents naturally-occurring readthrough transcription between the neighboring mediator complex subunit 20 (Med20) and ubiquitin specific peptidase 49 (Usp49) genes. Readthrough transcripts may be candidates for nonsense mediated decay (NMD) or encode proteins with similarity to the Med20 gene. [provided by RefSeq, Jul 2018]. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Nucleus Belongs to the Mediator complex subunit 20 family. transcription cofactor activity transcription coactivator activity nucleus regulation of transcription from RNA polymerase II promoter mediator complex positive regulation of nucleic acid-templated transcription uc289lqo.1 uc289lqo.2 
ENSMUST00000132470.2 Gm11261 ENSMUST00000132470.2 Gm11261 (from geneSymbol) ENSMUST00000132470.1 uc290nka.1 uc290nka.2 uc290nka.1 uc290nka.2 
ENSMUST00000132484.7 Spopl ENSMUST00000132484.7 speckle-type BTB/POZ protein-like, transcript variant 1 (from RefSeq NM_029773.2) A2AL52 ENSMUST00000132484.1 ENSMUST00000132484.2 ENSMUST00000132484.3 ENSMUST00000132484.4 ENSMUST00000132484.5 ENSMUST00000132484.6 NM_029773 Q2M2N2 Q3TSH4 SPOPL_MOUSE uc008ioh.1 uc008ioh.2 uc008ioh.3 uc008ioh.4 Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin- protein ligase complexes that contain SPOP (By similarity). Protein modification; protein ubiquitination. Homodimer. Heterodimer with SPOP. Component of cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Interacts with CUL3 and MACROH2A1 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2M2N2-1; Sequence=Displayed; Name=2; IsoId=Q2M2N2-2; Sequence=VSP_022824; Belongs to the Tdpoz family. Sequence=AAI11868.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE36701.1; Type=Frameshift; Evidence=; nucleus cytoplasm ubiquitin-dependent protein catabolic process protein ubiquitination regulation of proteolysis negative regulation of protein ubiquitination Cul3-RING ubiquitin ligase complex ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process uc008ioh.1 uc008ioh.2 uc008ioh.3 uc008ioh.4 
ENSMUST00000132485.2 Gm16206 ENSMUST00000132485.2 Gm16206 (from geneSymbol) AK035416 ENSMUST00000132485.1 uc290ffm.1 uc290ffm.2 uc290ffm.1 uc290ffm.2 
ENSMUST00000132487.2 Gm11190 ENSMUST00000132487.2 predicted gene 11190 (from RefSeq NR_033549.1) ENSMUST00000132487.1 NR_033549 uc011xzz.1 uc011xzz.2 uc011xzz.1 uc011xzz.2 
ENSMUST00000132494.8 Gm28036 ENSMUST00000132494.8 Gm28036 (from geneSymbol) BC058662 ENSMUST00000132494.1 ENSMUST00000132494.2 ENSMUST00000132494.3 ENSMUST00000132494.4 ENSMUST00000132494.5 ENSMUST00000132494.6 ENSMUST00000132494.7 Gm28036 V9GXJ1 V9GXJ1_MOUSE uc290bvd.1 uc290bvd.2 nucleic acid binding RNA binding uc290bvd.1 uc290bvd.2 
ENSMUST00000132517.8 Abca7 ENSMUST00000132517.8 ATP-binding cassette, sub-family A member 7, transcript variant 2 (from RefSeq NM_013850.2) ABCA7_MOUSE ENSMUST00000132517.1 ENSMUST00000132517.2 ENSMUST00000132517.3 ENSMUST00000132517.4 ENSMUST00000132517.5 ENSMUST00000132517.6 ENSMUST00000132517.7 NM_013850 Q91V24 Q9JL36 uc007gba.1 uc007gba.2 uc007gba.3 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is widely expressed with highest detection in spleen and hematopoietic tissues. Defects in this gene cause an increase in amyloid-beta deposits in a mouse model of Alzheimer's disease, and a related human protein is thought to play a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jan 2017]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AF287141.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## Probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:12917409, PubMed:15550377, PubMed:16908670, PubMed:27472885, PubMed:27030769, PubMed:20495215). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409). May also mediate cholesterol efflux (By similarity). May regulate cellular ceramide homeostasis during keratinocyte differentiation (By similarity). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (PubMed:28091533). Plays a role in phagocytosis of apoptotic cells by macrophages (PubMed:16908670). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (PubMed:20495215). Also involved in phagocytic clearance of amyloid- beta by microglia cells and macrophages (PubMed:27472885). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791, PubMed:27030769). Cell membrane ulti-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Cytoplasm Cell projection, ruffle membrane Cell projection, phagocytic cup Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes (PubMed:16908670). Localizes to the apical brush border of cells in the proximal tubules of kidney (Probable). Widely expressed with higher expression in brain, lung, adrenal gland, spleen and hematopoietic tissues (at protein level) (PubMed:12917409, PubMed:15550377, PubMed:27472885). In the brain, expressed in cortex, cerebellum, hippocampus, olfactory bulb, neurons, astrocytes and microglia (at protein level) (PubMed:26260791). Also expressed in adipocytes and macrophages (at protein level) (PubMed:15550377, PubMed:27472885). Expressed in thymocytes (at protein level) (PubMed:28091533). Highly expressed in spleen and hematopoietic tissues (PubMed:11435699). Expressed in brain, lung, macrophages, microglia, oligodendrocytes and neurons (PubMed:27472885). Widely expressed during embryogenesis (PubMed:11435699). Expressed in newborn mice with increasing expression from 4 to 24 weeks of age (PubMed:26260791). Up-regulated during differentiation from monocytes to macrophages (PubMed:27472885). Down-regulated by digoxin. N-glycosylated. According to one study, knockout mice are not viable and heterozygous knockout mice display impaired phagocytosis of apoptotic cells (PubMed:16908670). However, another study shows that knockout mice are viable and females have less visceral fat and lower total serum and high density lipoprotein cholesterol level (PubMed:15550377). Knockout mice exhibit altered lipid profile in mouse brains, compromised spatial memory and increased BACE1 activity (PubMed:27030769). Display an increase in amyloid-beta protein 42 (Abeta42) from 4 to 24 weeks of age, whereas amyloid-beta protein 40 (Abeta40) is increased at 4 weeks and decreased at 24 weeks of age (PubMed:26260791). Increased endocytotic uptake of APP into endosomes in primary microglia cells (PubMed:26260791). Reduced phagocytic uptake of Abeta42 and Abeta40 by microglia cells and phagocytes (PubMed:27472885). Decreased macrophage phagocytosis in the peritoneal cavity (PubMed:20495215). Decreased surface CD1D expression on double positive thymocytes, on antigen-presenting thymocytes, on peripheral antigen-presenting cells in the spleen and on peritoneal macrophages (PubMed:28091533). Increased accumulation of CD1D to late endosomes (PubMed:28091533). Impaired natural killer T (NKT) cell development with a 2-fold decrease in frequencies and total numbers of NKT cells in the thymus and a reduction of peripheral NKT cells in spleen and liver (PubMed:28091533). Reduced proliferation during early stages of NKT development and reduced expression of Egr2 in NKT cells (PubMed:28091533). Decreased number of plasma membrane lipid rafts on thymocytes and a reduction of CAV1 and CD1D clusters in macrophages (PubMed:28091533). RNAi-mediated knockdown reduces phagocytosis of apoptotic cells by macrophages (PubMed:16908670). Belongs to the ABC transporter superfamily. ABCA family. There are conflicting results concerning the role of ABCA7 in lipid transport. ABCA7 was described to play a role in apolipoprotein- mediated phospholipid and cholesterol efflux when expressed in HEK293 cells (PubMed:12917409, PubMed:27472885). However, another report shows that ABCA7 deficiency does not influence cholesterol and phospholipid efflux in mouse primary macrophages, but leads to lower serum HDL cholesterol levels and a reduction in fat mass in female mice (PubMed:15550377). Sequence=AAF31434.1; Type=Frameshift; Evidence=; Golgi membrane nucleotide binding phagocytic cup lipid transporter activity protein binding ATP binding phospholipid transporter activity cytoplasm endosome Golgi apparatus plasma membrane lipid transport phagocytosis memory cell surface positive regulation of cholesterol efflux membrane integral component of membrane apical plasma membrane ATPase activity peptide cross-linking cell junction early endosome membrane ruffle membrane cholesterol efflux phospholipid efflux apolipoprotein A-I receptor activity beta-amyloid formation high-density lipoprotein particle assembly protein localization to nucleus apolipoprotein A-I-mediated signaling pathway ATPase activity, coupled to transmembrane movement of substances negative regulation of amyloid precursor protein biosynthetic process cell projection intracellular membrane-bounded organelle plasma membrane raft organization phospholipid translocation negative regulation of endocytosis positive regulation of phagocytosis transmembrane transport positive regulation of ERK1 and ERK2 cascade phosphatidylcholine-translocating ATPase activity phosphatidylserine-translocating ATPase activity glial cell projection positive regulation of beta-amyloid clearance positive regulation of engulfment of apoptotic cell negative regulation of beta-amyloid formation regulation of amyloid precursor protein catabolic process positive regulation of phospholipid efflux positive regulation of protein localization to cell surface uc007gba.1 uc007gba.2 uc007gba.3 
ENSMUST00000132527.9 Col9a3 ENSMUST00000132527.9 Col9a3 (from geneSymbol) A2ACT7 A2ACT7_MOUSE AK030350 Col9a3 ENSMUST00000132527.1 ENSMUST00000132527.2 ENSMUST00000132527.3 ENSMUST00000132527.4 ENSMUST00000132527.5 ENSMUST00000132527.6 ENSMUST00000132527.7 ENSMUST00000132527.8 uc290djq.1 uc290djq.2 extracellular matrix structural constituent collagen trimer collagen type IX trimer extracellular space male gonad development female gonad development extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix uc290djq.1 uc290djq.2 
ENSMUST00000132553.2 Gm11934 ENSMUST00000132553.2 Gm11934 (from geneSymbol) AK038279 ENSMUST00000132553.1 uc290lqy.1 uc290lqy.2 uc290lqy.1 uc290lqy.2 
ENSMUST00000132564.3 Gm15287 ENSMUST00000132564.3 Gm15287 (from geneSymbol) ENSMUST00000132564.1 ENSMUST00000132564.2 uc288pxz.1 uc288pxz.2 uc288pxz.3 uc288pxz.1 uc288pxz.2 uc288pxz.3 
ENSMUST00000132571.3 Gm15972 ENSMUST00000132571.3 Gm15972 (from geneSymbol) ENSMUST00000132571.1 ENSMUST00000132571.2 uc056zfy.1 uc056zfy.2 uc056zfy.3 uc056zfy.4 uc056zfy.1 uc056zfy.2 uc056zfy.3 uc056zfy.4 
ENSMUST00000132657.2 Gm15870 ENSMUST00000132657.2 Gm15870 (from geneSymbol) ENSMUST00000132657.1 uc291jel.1 uc291jel.2 uc291jel.1 uc291jel.2 
ENSMUST00000132676.8 Pgs1 ENSMUST00000132676.8 phosphatidylglycerophosphate synthase 1 (from RefSeq NM_133757.2) ENSMUST00000132676.1 ENSMUST00000132676.2 ENSMUST00000132676.3 ENSMUST00000132676.4 ENSMUST00000132676.5 ENSMUST00000132676.6 ENSMUST00000132676.7 NM_133757 PGPS1_MOUSE Q8BHF7 Q8QZT9 Q8R4R7 Saf uc007moj.1 uc007moj.2 uc007moj.3 Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin. Reaction=a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2- diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+); Xref=Rhea:RHEA:12593, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597, ChEBI:CHEBI:58332, ChEBI:CHEBI:60110, ChEBI:CHEBI:60377; EC=2.7.8.5; Activated by calcium and magnesium and inhibited by other bivalent cations. Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2. Mitochondrion Widely expressed with higher expression in testis, liver and brain. Belongs to the CDP-alcohol phosphatidyltransferase class-II family. Sequence=AAH22918.1; Type=Erroneous initiation; Evidence=; Sequence=AAL87040.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; nucleotide binding catalytic activity ATP binding mitochondrion endoplasmic reticulum lipid metabolic process phosphatidylglycerol biosynthetic process biological_process CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity phospholipid biosynthetic process transferase activity cardiolipin biosynthetic process diacylglycerol metabolic process uc007moj.1 uc007moj.2 uc007moj.3 
ENSMUST00000132685.9 Dnah17 ENSMUST00000132685.9 Belongs to the dynein heavy chain family. (from UniProt A2A520) A2A520 A2A520_MOUSE AK173343 Dnah17 Dnahc17 ENSMUST00000132685.1 ENSMUST00000132685.2 ENSMUST00000132685.3 ENSMUST00000132685.4 ENSMUST00000132685.5 ENSMUST00000132685.6 ENSMUST00000132685.7 ENSMUST00000132685.8 uc288dyn.1 uc288dyn.2 Belongs to the dynein heavy chain family. microtubule motor activity ATP binding microtubule-based movement dynein complex uc288dyn.1 uc288dyn.2 
ENSMUST00000132691.3 Timd7-ps ENSMUST00000132691.3 T cell immunoglobulin and mucin domain containing 7, pseudogene (from RefSeq NR_028066.1) ENSMUST00000132691.1 ENSMUST00000132691.2 NR_028066 uc007ior.1 uc007ior.2 uc007ior.3 uc007ior.4 uc007ior.5 uc007ior.1 uc007ior.2 uc007ior.3 uc007ior.4 uc007ior.5 
ENSMUST00000132692.3 Gm13556 ENSMUST00000132692.3 Gm13556 (from geneSymbol) ENSMUST00000132692.1 ENSMUST00000132692.2 uc289vss.1 uc289vss.2 uc289vss.1 uc289vss.2 
ENSMUST00000132728.8 Eif4e1b ENSMUST00000132728.8 eukaryotic translation initiation factor 4E family member 1B, transcript variant 1 (from RefSeq NM_001033269.3) ENSMUST00000132728.1 ENSMUST00000132728.2 ENSMUST00000132728.3 ENSMUST00000132728.4 ENSMUST00000132728.5 ENSMUST00000132728.6 ENSMUST00000132728.7 Gm273 I4E1B_MOUSE NM_001033269 Q27ZJ1 Q3UTA9 uc007qph.1 uc007qph.2 uc007qph.3 uc007qph.4 uc007qph.5 Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. EIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G (By similarity). Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q3UTA9-1; Sequence=Displayed; Name=2; IsoId=Q3UTA9-2; Sequence=VSP_034476, VSP_034477; Belongs to the eukaryotic initiation factor 4E family. RNA 7-methylguanosine cap binding RNA binding translation initiation factor activity cytoplasm mRNA cap binding complex translation translational initiation eukaryotic translation initiation factor 4F complex uc007qph.1 uc007qph.2 uc007qph.3 uc007qph.4 uc007qph.5 
ENSMUST00000132731.2 Gm6270 ENSMUST00000132731.2 Gm6270 (from geneSymbol) ENSMUST00000132731.1 uc288pxd.1 uc288pxd.2 uc288pxd.1 uc288pxd.2 
ENSMUST00000132734.8 Ppargc1a ENSMUST00000132734.8 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha, transcript variant 11 (from RefSeq NR_175327.1) ENSMUST00000132734.1 ENSMUST00000132734.2 ENSMUST00000132734.3 ENSMUST00000132734.4 ENSMUST00000132734.5 ENSMUST00000132734.6 ENSMUST00000132734.7 L0AM20 L0AN96 L0APB0 NR_175327 O70343 PRGC1_MOUSE Pgc1 Pgc1a Ppargc1 Q3UP72 uc008xkc.1 uc008xkc.2 uc008xkc.3 uc008xkc.4 Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:15744310, PubMed:12754525, PubMed:23217713, PubMed:9529258). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:15744310, PubMed:12754525, PubMed:23217713, PubMed:9529258). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:15744310, PubMed:12754525, PubMed:23217713, PubMed:9529258). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:15744310, PubMed:12754525, PubMed:23217713, PubMed:9529258). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:12754525). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (By similarity). Also involved in the integration of the circadian rhythms and energy metabolism (PubMed:17476214). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (PubMed:17476214). Homooligomer (By similarity). Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation (PubMed:14744933). Interacts with PRDM16, LPIN1 and PML (PubMed:16950137, PubMed:17618855, PubMed:18483224, PubMed:22886304). Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation (PubMed:17476214). Interacts with LRPPRC (By similarity). Interacts with FOXO1 (PubMed:12754525). O70343; Q64287: Irf4; NbExp=6; IntAct=EBI-1371053, EBI-6398485; O70343; Q6PB66: Lrpprc; NbExp=2; IntAct=EBI-1371053, EBI-1371262; O70343; Q923E4: Sirt1; NbExp=6; IntAct=EBI-1371053, EBI-1802585; O70343; Q00899: Yy1; NbExp=5; IntAct=EBI-1371053, EBI-6921536; O70343; Q6GMV2: SMYD5; Xeno; NbExp=4; IntAct=EBI-1371053, EBI-11057552; O70343-1; Q60641-1: Nr1h4; NbExp=3; IntAct=EBI-11359934, EBI-11659377; O70343-1; Q60641-2: Nr1h4; NbExp=2; IntAct=EBI-11359934, EBI-11659386; Nucleus cleus, PML body Event=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=1; Synonyms=PGC-1a1; IsoId=O70343-1; Sequence=Displayed; Name=2; Synonyms=PGC-1a2; IsoId=O70343-2; Sequence=VSP_053275, VSP_053277, VSP_053278, VSP_053280; Name=3; Synonyms=PGC-1a3; IsoId=O70343-3; Sequence=VSP_053276, VSP_053277, VSP_053278, VSP_053280; Name=4; Synonyms=PGC-1a4; IsoId=O70343-4; Sequence=VSP_053275, VSP_053279, VSP_053281; White quadriceps and red tibialis anterior (TA) muscles, liver, kidney and brown adipose tissue (at protein level). Skeletal muscle, brown adipose tissue, heart, kidney and brain. Dramatically induced in brown adipose tissue and skeletal muscle by exposure of animals to cold. Up-regulated in brown adipose tissue of obese leptin-deficient (ob/ob) and leptin-unresponsive (db/db) mice. Leptin is required for normal basal and cold-stimulated expression in brown adipose tissue and hyperleptinemia rapidly up- regulates its expression. Induced in muscle by exercise. Oscillates diurnally in liver and skeletal muscle. Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter (PubMed:17609368). Phosphorylated by CLK2 (PubMed:20074525). Heavily acetylated by KAT2A/GCN5 under conditions of high nutrients, leading to inactivation of PPARGC1A (PubMed:15744310). Deacetylated by SIRT1 in low nutrients/high NAD conditions, leading to its activation (PubMed:15716268, PubMed:15744310). Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation. Mice show abnormal diurnal rhythms of activity, body temperature and metabolic rate. [Isoform 2]: Produced by alternative promoter usage and alternative splicing. [Isoform 3]: Produced by alternative promoter usage and alternative splicing. [Isoform 4]: Produced by alternative promoter usage and alternative splicing. response to reactive oxygen species mitophagy response to hypoxia negative regulation of protein phosphorylation response to dietary excess response to ischemia nucleic acid binding DNA binding chromatin binding transcription cofactor activity transcription coactivator activity RNA binding receptor binding protein binding nucleus nucleoplasm nuclear euchromatin cytoplasm cytosol galactose metabolic process gluconeogenesis regulation of transcription, DNA-templated mitochondrion organization aging transcription factor binding androgen metabolic process response to cold response to fructose positive regulation of gene expression positive regulation of mitochondrion organization response to organic cyclic compound skeletal muscle atrophy response to activity response to muscle activity response to electrical stimulus involved in regulation of muscle adaptation negative regulation of smooth muscle cell migration PML body ligand-dependent nuclear receptor binding fatty acid oxidation cerebellum development cytosolic ribosome respiratory electron transport chain estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity forebrain development positive regulation of cellular metabolic process chromatin DNA binding ubiquitin protein ligase binding response to nutrient levels circadian regulation of gene expression cellular response to oxidative stress cellular response to potassium ion response to drug response to starvation regulation of circadian rhythm peroxisome proliferator activated receptor binding alpha-tubulin binding neuronal cell body response to leucine intracellular membrane-bounded organelle negative regulation of neuron apoptotic process sequence-specific DNA binding negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation rhythmic process positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation brown fat cell differentiation positive regulation of sequence-specific DNA binding transcription factor activity flavone metabolic process response to electrical stimulus adipose tissue development cellular response to lipopolysaccharide cellular response to nitrite cellular response to caffeine cellular response to fructose stimulus cellular response to glucose stimulus cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to follicle-stimulating hormone stimulus cellular response to estradiol stimulus cellular response to fatty acid cellular response to hypoxia cellular response to transforming growth factor beta stimulus response to epinephrine response to norepinephrine negative regulation of mitochondrial fission energy homeostasis response to thyroid hormone cellular response to thyroid hormone stimulus apical dendrite negative regulation of neuron death response to metformin positive regulation of cellular respiration positive regulation of mitochondrial DNA metabolic process positive regulation of muscle tissue development positive regulation of glomerular visceral epithelial cell apoptotic process cellular response to ionomycin cellular response to resveratrol response to methionine promoter-specific chromatin binding subsarcolemmal mitochondrion interfibrillar mitochondrion adaptive thermogenesis positive regulation of progesterone biosynthetic process negative regulation of receptor activity regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of ATP biosynthetic process uc008xkc.1 uc008xkc.2 uc008xkc.3 uc008xkc.4 
ENSMUST00000132759.3 Gm11917 ENSMUST00000132759.3 Gm11917 (from geneSymbol) ENSMUST00000132759.1 ENSMUST00000132759.2 uc290loi.1 uc290loi.2 uc290loi.3 uc290loi.1 uc290loi.2 uc290loi.3 
ENSMUST00000132762.4 Gm15551 ENSMUST00000132762.4 predicted gene 15551 (from RefSeq NR_166466.1) ENSMUST00000132762.1 ENSMUST00000132762.2 ENSMUST00000132762.3 NR_166466 uc008rgq.1 uc008rgq.2 uc008rgq.3 uc008rgq.4 uc008rgq.1 uc008rgq.2 uc008rgq.3 uc008rgq.4 
ENSMUST00000132792.2 Rapgef4os3 ENSMUST00000132792.2 Rapgef4os3 (from geneSymbol) AK076344 ENSMUST00000132792.1 uc289wwi.1 uc289wwi.2 uc289wwi.1 uc289wwi.2 
ENSMUST00000132822.3 4930474H06Rik ENSMUST00000132822.3 4930474H06Rik (from geneSymbol) AK014974 ENSMUST00000132822.1 ENSMUST00000132822.2 uc007nur.1 uc007nur.2 uc007nur.3 uc007nur.1 uc007nur.2 uc007nur.3 
ENSMUST00000132826.3 Gm7580 ENSMUST00000132826.3 Gm7580 (from geneSymbol) ENSMUST00000132826.1 ENSMUST00000132826.2 uc291rlw.1 uc291rlw.2 uc291rlw.3 uc291rlw.1 uc291rlw.2 uc291rlw.3 
ENSMUST00000132846.2 Ppia ENSMUST00000132846.2 peptidylprolyl isomerase A (from RefSeq NM_008907.2) ENSMUST00000132846.1 NM_008907 Ppia Q5SVY2 Q5SVY2_MOUSE uc007hyn.1 uc007hyn.2 uc007hyn.3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=; Cytoplasm Nucleus Secreted Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity protein folding isomerase activity uc007hyn.1 uc007hyn.2 uc007hyn.3 
ENSMUST00000132849.2 Gm15582 ENSMUST00000132849.2 Gm15582 (from geneSymbol) AK136833 ENSMUST00000132849.1 uc291wjv.1 uc291wjv.2 uc291wjv.1 uc291wjv.2 
ENSMUST00000132855.8 Wipf3 ENSMUST00000132855.8 WAS/WASL interacting protein family, member 3, transcript variant 1 (from RefSeq NM_001167860.2) E9Q2D0 E9Q2D0_MOUSE ENSMUST00000132855.1 ENSMUST00000132855.2 ENSMUST00000132855.3 ENSMUST00000132855.4 ENSMUST00000132855.5 ENSMUST00000132855.6 ENSMUST00000132855.7 NM_001167860 Wipf3 uc291epx.1 uc291epx.2 actin binding SH3 domain binding uc291epx.1 uc291epx.2 
ENSMUST00000132859.8 Ccdc191 ENSMUST00000132859.8 Ccdc191 (from geneSymbol) 2610015P09Rik B8JJH0 B8JJH0_MOUSE BC021827 Ccdc191 ENSMUST00000132859.1 ENSMUST00000132859.2 ENSMUST00000132859.3 ENSMUST00000132859.4 ENSMUST00000132859.5 ENSMUST00000132859.6 ENSMUST00000132859.7 uc289eto.1 uc289eto.2 molecular_function cellular_component biological_process uc289eto.1 uc289eto.2 
ENSMUST00000132880.3 Gm15290 ENSMUST00000132880.3 predicted gene 15290 (from RefSeq NR_151444.1) ENSMUST00000132880.1 ENSMUST00000132880.2 NR_151444 uc288pxj.1 uc288pxj.2 uc288pxj.1 uc288pxj.2 
ENSMUST00000132883.8 Gm14295 ENSMUST00000132883.8 Gm14295 (from geneSymbol) A2BG91 A2BG91_MOUSE BC087864 ENSMUST00000132883.1 ENSMUST00000132883.2 ENSMUST00000132883.3 ENSMUST00000132883.4 ENSMUST00000132883.5 ENSMUST00000132883.6 ENSMUST00000132883.7 Gm14295 RP23-86F8.3-002 uc290des.1 uc290des.2 nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc290des.1 uc290des.2 
ENSMUST00000132961.2 Smim6 ENSMUST00000132961.2 small integral membrane protein 6 (from RefSeq NM_001162998.1) 1110017F19Rik ENSMUST00000132961.1 NM_001162998 Q3U0I6 Q3U0I6_MOUSE Smim6 uc011yhr.1 uc011yhr.2 uc011yhr.3 protein binding endoplasmic reticulum membrane membrane integral component of membrane negative regulation of calcium ion binding negative regulation of calcium-transporting ATPase activity uc011yhr.1 uc011yhr.2 uc011yhr.3 
ENSMUST00000133010.4 Dpy19l2 ENSMUST00000133010.4 dpy-19 like 2 (from RefSeq NM_001166207.1) D19L2_MOUSE ENSMUST00000133010.1 ENSMUST00000133010.2 ENSMUST00000133010.3 NM_001166207 P0CW70 uc009opc.1 uc009opc.2 uc009opc.3 uc009opc.4 Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation. Also plays a role in acrosome attachment to the nuclear envelope. Interacts with FAM209. Nucleus inner membrane ; Multi-pass membrane protein Note=Restricted to the inner nuclear membrane facing the acrosomal vesicle. The N- and C-termini are oriented towards the nucleoplasm (PubMed:22764053). Colocalizes with FAM209 at the inner nuclear membrane (PubMed:34471926). Predominantly expressed in testis. Present in testis but absent from epididymal sperm (at protein level). Deficient male exhibit sterility associated with globozoospermia. Belongs to the dpy-19 family. mannosyltransferase activity nuclear inner membrane multicellular organism development spermatogenesis spermatid development membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan cell differentiation uc009opc.1 uc009opc.2 uc009opc.3 uc009opc.4 
ENSMUST00000133025.2 Gm13553 ENSMUST00000133025.2 Gm13553 (from geneSymbol) AK044361 ENSMUST00000133025.1 uc289uch.1 uc289uch.2 uc289uch.1 uc289uch.2 
ENSMUST00000133144.4 Alkal1 ENSMUST00000133144.4 ALK and LTK ligand 1 (from RefSeq NM_001195732.1) ALKL1_MOUSE Alkal1 ENSMUST00000133144.1 ENSMUST00000133144.2 ENSMUST00000133144.3 Fam150a J3QPP8 NM_001195732 uc007afv.1 uc007afv.2 uc007afv.3 uc007afv.4 Cytokine that acts as a physiological ligand for receptor tyrosine kinase LTK, leading to its activation. Monomeric ALKAL1 binds to LTK, leading to LTK homodimerization and activation. In contrast to ALKAL2, does not act as a potent physiological ligand for ALK. Secreted Cell membrane Note=Following interaction with receptor tyrosine kinase LTK, associates with the cell membrane, membrane-binding is required to activate LTK. Belongs to the ALKAL family. cellular_component extracellular region positive regulation of neuron projection development receptor signaling protein tyrosine kinase activator activity receptor tyrosine kinase binding positive regulation of protein tyrosine kinase activity positive regulation of ERK1 and ERK2 cascade positive regulation of ERK5 cascade uc007afv.1 uc007afv.2 uc007afv.3 uc007afv.4 
ENSMUST00000133148.3 Evi2a ENSMUST00000133148.3 ecotropic viral integration site 2a, transcript variant 1 (from RefSeq NM_001033711.1) ENSMUST00000133148.1 ENSMUST00000133148.2 EVI2A_MOUSE Evi-2 Evi-2a Evi2 NM_001033711 P20934 Q6DKP1 uc288aqt.1 uc288aqt.2 uc288aqt.3 May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor. Membrane; Single-pass type I membrane protein. Note=Expression of this gene is altered by viral integration and this altered expression may predispose cells to myeloid disease (PubMed:2167436). Belongs to the EVI2A family. membrane integral component of membrane uc288aqt.1 uc288aqt.2 uc288aqt.3 
ENSMUST00000133154.7 Fnip2 ENSMUST00000133154.7 folliculin interacting protein 2, transcript variant 2 (from RefSeq NM_001405166.1) D3YUC5 D3YUC5_MOUSE ENSMUST00000133154.1 ENSMUST00000133154.2 ENSMUST00000133154.3 ENSMUST00000133154.4 ENSMUST00000133154.5 ENSMUST00000133154.6 Fnip2 NM_001405166 uc290gbc.1 uc290gbc.2 Lysosome membrane Membrane Belongs to the FNIP family. uc290gbc.1 uc290gbc.2 
ENSMUST00000133157.8 Polr1e ENSMUST00000133157.8 polymerase (RNA) I polypeptide E, transcript variant 2 (from RefSeq NM_022811.3) B1AXQ6 B1AXQ7 ENSMUST00000133157.1 ENSMUST00000133157.2 ENSMUST00000133157.3 ENSMUST00000133157.4 ENSMUST00000133157.5 ENSMUST00000133157.6 ENSMUST00000133157.7 NM_022811 Paf53 Praf1 Q62034 Q8BQG9 Q8K202 RPA49_MOUSE uc008sse.1 uc008sse.2 uc008sse.3 uc008sse.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors (PubMed:8641287, PubMed:9254723). Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:8641287). Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (PubMed:9254723). Interacts with POLR1G (PubMed:15226435). Also binds UBTF/UBF (PubMed:8641287). Interacts with PWP1 (By similarity). Nucleus, nucleolus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K202-1; Sequence=Displayed; Name=2; IsoId=Q8K202-2; Sequence=VSP_013536; Name=3; IsoId=Q8K202-3; Sequence=VSP_013536, VSP_013537, VSP_013538; Acetylated at Lys-436 by CREBBP/CBP, leading to decreased RNA polymerase I transcription. In normal conditions, deacetylated by SIRT7, promoting the association of RNA polymerase I with the rDNA promoter region and coding region. In response to stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased association of RNA polymerase I with the rDNA promoter region. Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family. RNA polymerase I transcription factor binding RNA polymerase I transcriptional preinitiation complex assembly fibrillar center DNA binding DNA-directed 5'-3' RNA polymerase activity protein binding nucleus nucleoplasm nucleolus DNA-directed RNA polymerase I complex transcription, DNA-templated transcription elongation from RNA polymerase I promoter transcription of nuclear large rRNA transcript from RNA polymerase I promoter RNA polymerase I activity uc008sse.1 uc008sse.2 uc008sse.3 uc008sse.4 
ENSMUST00000133179.3 Gm17077 ENSMUST00000133179.3 Gm17077 (from geneSymbol) ENSMUST00000133179.1 ENSMUST00000133179.2 uc291oca.1 uc291oca.2 uc291oca.1 uc291oca.2 
ENSMUST00000133181.2 Cdc23 ENSMUST00000133181.2 CDC23 cell division cycle 23 (from RefSeq NM_178347.4) A0A0R4J1W7 A0A0R4J1W7_MOUSE Cdc23 ENSMUST00000133181.1 NM_178347 uc008elc.1 uc008elc.2 uc008elc.3 Protein modification; protein ubiquitination. mitotic cell cycle anaphase-promoting complex mitotic metaphase plate congression regulation of mitotic metaphase/anaphase transition cell division protein K11-linked ubiquitination uc008elc.1 uc008elc.2 uc008elc.3 
ENSMUST00000133196.3 Gm13049 ENSMUST00000133196.3 Gm13049 (from geneSymbol) AK033051 ENSMUST00000133196.1 ENSMUST00000133196.2 uc008vxv.1 uc008vxv.2 uc008vxv.3 uc008vxv.1 uc008vxv.2 uc008vxv.3 
ENSMUST00000133243.5 Gm15411 ENSMUST00000133243.5 Gm15411 (from geneSymbol) AK158390 ENSMUST00000133243.1 ENSMUST00000133243.2 ENSMUST00000133243.3 ENSMUST00000133243.4 uc029vqu.1 uc029vqu.2 uc029vqu.3 uc029vqu.1 uc029vqu.2 uc029vqu.3 
ENSMUST00000133244.3 Gm13749 ENSMUST00000133244.3 predicted gene 13749 (from RefSeq NR_027824.1) ENSMUST00000133244.1 ENSMUST00000133244.2 NR_027824 uc007bgm.1 uc007bgm.2 uc007bgm.3 uc007bgm.4 uc007bgm.5 uc007bgm.1 uc007bgm.2 uc007bgm.3 uc007bgm.4 uc007bgm.5 
ENSMUST00000133257.9 Gm50253 ENSMUST00000133257.9 May be involved in transcriptional regulation. (from UniProt Q8CDC7) BC054732 ENSMUST00000133257.1 ENSMUST00000133257.2 ENSMUST00000133257.3 ENSMUST00000133257.4 ENSMUST00000133257.5 ENSMUST00000133257.6 ENSMUST00000133257.7 ENSMUST00000133257.8 Q3U3B2 Q8CDC7 Q9CYQ0 ZBTB9_MOUSE Zbtb9 uc008bfh.1 uc008bfh.2 uc008bfh.3 uc008bfh.4 uc008bfh.5 May be involved in transcriptional regulation. Nucleus nucleic acid binding DNA binding nucleus biological_process metal ion binding uc008bfh.1 uc008bfh.2 uc008bfh.3 uc008bfh.4 uc008bfh.5 
ENSMUST00000133270.2 Gm16229 ENSMUST00000133270.2 Gm16229 (from geneSymbol) BC029853 ENSMUST00000133270.1 uc011xpu.1 uc011xpu.2 uc011xpu.3 uc011xpu.1 uc011xpu.2 uc011xpu.3 
ENSMUST00000133272.2 Sbk3 ENSMUST00000133272.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; (from UniProt P0C5K0) AK138915 D3Z5J0 E9QLM1 ENSMUST00000133272.1 Gm1078 P0C5K0 SBK3_MOUSE Sgk110 uc291kxq.1 uc291kxq.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P0C5K0-1; Sequence=Displayed; Name=2; IsoId=P0C5K0-2; Sequence=VSP_053507; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding cellular_component protein phosphorylation kinase activity phosphorylation transferase activity uc291kxq.1 uc291kxq.2 
ENSMUST00000133273.4 Gm17025 ENSMUST00000133273.4 predicted gene 17025 (from RefSeq NR_166833.1) ENSMUST00000133273.1 ENSMUST00000133273.2 ENSMUST00000133273.3 NR_166833 uc288zxg.1 uc288zxg.2 uc288zxg.3 uc288zxg.1 uc288zxg.2 uc288zxg.3 
ENSMUST00000133274.4 Gm15420 ENSMUST00000133274.4 predicted gene 15420 (from RefSeq NR_167724.1) ENSMUST00000133274.1 ENSMUST00000133274.2 ENSMUST00000133274.3 NR_167724 uc289iud.1 uc289iud.2 uc289iud.3 uc289iud.1 uc289iud.2 uc289iud.3 
ENSMUST00000133280.2 Shld3 ENSMUST00000133280.2 shieldin complex subunit 3 (from RefSeq NM_001365338.2) ENSMUST00000133280.1 NM_001365338 Q9CZV2 Rinn1 SHLD3_MOUSE Shld3 uc288psb.1 uc288psb.2 Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. Component of the shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and MAD2L2/REV7. Within the complex, SHLD2 forms a scaffold which interacts with a SHLD3-MAD2L2 subcomplex via its N-terminus, and with SHLD1 via its C-terminus. Chromosome Note=Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle. chromosome DNA repair cellular response to DNA damage stimulus regulation of double-strand break repair via homologous recombination positive regulation of isotype switching negative regulation of double-strand break repair via homologous recombination positive regulation of double-strand break repair via nonhomologous end joining uc288psb.1 uc288psb.2 
ENSMUST00000133298.8 Dlgap2 ENSMUST00000133298.8 DLG associated protein 2, transcript variant 1 (from RefSeq NM_172910.3) DLGP2_MOUSE Dap2 Dlgap2 ENSMUST00000133298.1 ENSMUST00000133298.2 ENSMUST00000133298.3 ENSMUST00000133298.4 ENSMUST00000133298.5 ENSMUST00000133298.6 ENSMUST00000133298.7 NM_172910 Q6XBF3 Q8BJ42 uc009kyy.1 uc009kyy.2 uc009kyy.3 uc009kyy.4 uc009kyy.5 May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD- 95/SAP90 at the plasma membrane. Interacts with DLG4/PSD-95. Cell membrane ; Peripheral membrane protein Postsynaptic density Synapse Note=Postsynaptic density of neuronal cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BJ42-1; Sequence=Displayed; Name=2; IsoId=Q8BJ42-2; Sequence=VSP_014817; Expressed in various brain areas. Belongs to the SAPAP family. plasma membrane neuron-neuron synaptic transmission postsynaptic density membrane protein domain specific binding signaling cell junction dendrite dendritic spine synapse postsynaptic membrane regulation of postsynaptic neurotransmitter receptor activity uc009kyy.1 uc009kyy.2 uc009kyy.3 uc009kyy.4 uc009kyy.5 
ENSMUST00000133301.9 Gm14410 ENSMUST00000133301.9 predicted gene 14410 (from RefSeq NM_001374129.1) A2ARW1 A2ARW1_MOUSE ENSMUST00000133301.1 ENSMUST00000133301.2 ENSMUST00000133301.3 ENSMUST00000133301.4 ENSMUST00000133301.5 ENSMUST00000133301.6 ENSMUST00000133301.7 ENSMUST00000133301.8 Gm14410 NM_001374129 uc290dfs.1 uc290dfs.2 uc290dfs.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc290dfs.1 uc290dfs.2 uc290dfs.3 
ENSMUST00000133337.9 Irx3os ENSMUST00000133337.9 Irx3os (from geneSymbol) AK084136 ENSMUST00000133337.1 ENSMUST00000133337.2 ENSMUST00000133337.3 ENSMUST00000133337.4 ENSMUST00000133337.5 ENSMUST00000133337.6 ENSMUST00000133337.7 ENSMUST00000133337.8 uc292cal.1 uc292cal.2 uc292cal.3 uc292cal.1 uc292cal.2 uc292cal.3 
ENSMUST00000133363.2 Gm11867 ENSMUST00000133363.2 Gm11867 (from geneSymbol) AK043496 ENSMUST00000133363.1 uc290liy.1 uc290liy.2 uc290liy.1 uc290liy.2 
ENSMUST00000133371.8 Stox1 ENSMUST00000133371.8 storkhead box 1, transcript variant 1 (from RefSeq NM_001033260.2) B2RQL2 ENSMUST00000133371.1 ENSMUST00000133371.2 ENSMUST00000133371.3 ENSMUST00000133371.4 ENSMUST00000133371.5 ENSMUST00000133371.6 ENSMUST00000133371.7 NM_001033260 Q3UZS9 STOX1_MOUSE Stox1 uc011xfe.1 uc011xfe.2 uc011xfe.3 Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (By similarity). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (PubMed:25677106). Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (By similarity). Induces phosphorylation of MAPT/tau (By similarity). Nucleus Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=In epithelial cells, diffusely expressed in the cytoplasm, particularly in peri-membrane cortical regions (PubMed:25677106). Concentrated at centrosomes during metaphase (By similarity). Detected in sensory epithelial cells of the inner ear but not in adjacent surrounding tissue (at protein level). Highly expressed at 14 dpc with lower levels at 18 dpc and P3. Sequence=BAE21776.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding fibrillar center DNA binding nucleus nucleoplasm cytoplasm centrosome microtubule organizing center cytosol cytoskeleton cell cortex regulation of transcription from RNA polymerase II promoter cell cycle positive regulation of cell proliferation regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of peptidyl-threonine phosphorylation regulation of mitochondrion organization positive regulation of G2/M transition of mitotic cell cycle positive regulation of peptidyl-serine phosphorylation positive regulation of cell cycle inner ear development positive regulation of epithelial cell proliferation cell division regulation of mitochondrial membrane potential positive regulation of protein kinase B signaling regulation of transcription from RNA polymerase II promoter in response to hypoxia cellular response to nitrosative stress regulation of mitochondrial DNA metabolic process regulation of response to oxidative stress positive regulation of cyclin-dependent protein kinase activity positive regulation of otic vesicle morphogenesis uc011xfe.1 uc011xfe.2 uc011xfe.3 
ENSMUST00000133391.2 Gm13327 ENSMUST00000133391.2 Gm13327 (from geneSymbol) ENSMUST00000133391.1 uc289tmp.1 uc289tmp.2 uc289tmp.1 uc289tmp.2 
ENSMUST00000133431.2 C230012O17Rik ENSMUST00000133431.2 C230012O17Rik (from geneSymbol) AK044654 ENSMUST00000133431.1 uc290lml.1 uc290lml.2 uc290lml.1 uc290lml.2 
ENSMUST00000133433.8 Cfap61 ENSMUST00000133433.8 cilia and flagella associated protein 61, transcript variant 1 (from RefSeq NM_001369121.1) 4930529M08Rik A8Y5L4 A8Y5L4_MOUSE B2FDI8 Cfap61 ENSMUST00000133433.1 ENSMUST00000133433.2 ENSMUST00000133433.3 ENSMUST00000133433.4 ENSMUST00000133433.5 ENSMUST00000133433.6 ENSMUST00000133433.7 NM_001369121 uc290bcd.1 uc290bcd.2 uc290bcd.1 uc290bcd.2 
ENSMUST00000133437.3 Btbd18 ENSMUST00000133437.3 BTB domain containing 18 (from RefSeq NM_001145100.1) A0A0A6YY25 BTBDI_MOUSE Btbd18 ENSMUST00000133437.1 ENSMUST00000133437.2 NM_001145100 uc012byl.1 uc012byl.2 uc012byl.3 Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene. Nucleus Expressed in testis. Expressed during pachytene in testis: accumulates in early pachytene cells (stages I-VII), declines in late pachytene cells (stages VIII-X) and disappears in diplotene cells (stage XI) (at protein level). Expressed from spermatogonia to spermatids, with trace expression in mature spermatozoa and somatic Sertoli cells. Mice are viable but show male sterility due to defects in spermatogenesis. Retrotransposons are derepressed due to DNA demethylation. Defects are caused by impaired piRNA biogenesis. nucleus male meiosis I spermatogenesis negative regulation of transposition cell differentiation positive regulation of transcription elongation from RNA polymerase II promoter piRNA biosynthetic process uc012byl.1 uc012byl.2 uc012byl.3 
ENSMUST00000133451.2 Bach2it1 ENSMUST00000133451.2 Bach2it1 (from geneSymbol) ENSMUST00000133451.1 KY467972 uc057lhh.1 uc057lhh.2 uc057lhh.3 uc057lhh.1 uc057lhh.2 uc057lhh.3 
ENSMUST00000133455.2 Kank4os ENSMUST00000133455.2 KN motif and ankyrin repeat domains 4, opposite strand (from RefSeq NR_040437.1) ENSMUST00000133455.1 NR_040437 uc008tul.1 uc008tul.2 uc008tul.3 uc008tul.4 uc008tul.1 uc008tul.2 uc008tul.3 uc008tul.4 
ENSMUST00000133459.8 Pcp2 ENSMUST00000133459.8 Purkinje cell protein 2 (L7), transcript variant 4 (from RefSeq NM_001372442.1) ENSMUST00000133459.1 ENSMUST00000133459.2 ENSMUST00000133459.3 ENSMUST00000133459.4 ENSMUST00000133459.5 ENSMUST00000133459.6 ENSMUST00000133459.7 NM_001372442 P12660 P22941 PCP2_MOUSE Pcp-2 Q3TV53 uc009ksa.1 uc009ksa.2 uc009ksa.3 uc009ksa.4 May function as a cell-type specific modulator for G protein- mediated cell signaling. Cerebellum (Purkinje cells) and retinal bipolar neurons. Sequence=AAA02989.1; Type=Erroneous initiation; Evidence=; Sequence=AAB19316.1; Type=Erroneous gene model prediction; Evidence=; Sequence=BAC25015.1; Type=Erroneous initiation; Evidence=; Sequence=BAE35767.1; Type=Erroneous initiation; Evidence=; Sequence=Ref.2; Type=Frameshift; Evidence=; guanyl-nucleotide exchange factor activity rhodopsin mediated signaling pathway GTPase regulator activity regulation of catalytic activity uc009ksa.1 uc009ksa.2 uc009ksa.3 uc009ksa.4 
ENSMUST00000133476.2 Gm15857 ENSMUST00000133476.2 Gm15857 (from geneSymbol) ENSMUST00000133476.1 uc290zoz.1 uc290zoz.2 uc290zoz.1 uc290zoz.2 
ENSMUST00000133493.9 Ube2u ENSMUST00000133493.9 ubiquitin-conjugating enzyme E2U (putative) (from RefSeq NM_001033773.4) B1AUC4 B1AUC4_MOUSE ENSMUST00000133493.1 ENSMUST00000133493.2 ENSMUST00000133493.3 ENSMUST00000133493.4 ENSMUST00000133493.5 ENSMUST00000133493.6 ENSMUST00000133493.7 ENSMUST00000133493.8 NM_001033773 Ube2u uc012dhj.1 uc012dhj.2 uc012dhj.3 ubiquitin ligase complex ubiquitin-dependent protein catabolic process protein ubiquitination ubiquitin protein ligase binding ubiquitin conjugating enzyme activity uc012dhj.1 uc012dhj.2 uc012dhj.3 
ENSMUST00000133499.3 4933407E24Rik ENSMUST00000133499.3 4933407E24Rik (from geneSymbol) AK160260 ENSMUST00000133499.1 ENSMUST00000133499.2 uc008uqs.1 uc008uqs.2 uc008uqs.3 uc008uqs.4 uc008uqs.5 uc008uqs.1 uc008uqs.2 uc008uqs.3 uc008uqs.4 uc008uqs.5 
ENSMUST00000133525.2 Gm14272 ENSMUST00000133525.2 Gm14272 (from geneSymbol) ENSMUST00000133525.1 uc290cxd.1 uc290cxd.2 uc290cxd.1 uc290cxd.2 
ENSMUST00000133533.8 Trp73 ENSMUST00000133533.8 transformation related protein 73, transcript variant 2 (from RefSeq NM_001126330.1) B1AX89 B1AX90 ENSMUST00000133533.1 ENSMUST00000133533.2 ENSMUST00000133533.3 ENSMUST00000133533.4 ENSMUST00000133533.5 ENSMUST00000133533.6 ENSMUST00000133533.7 NM_001126330 P73 P73_MOUSE Q3UT91 Q9CU77 Q9JJP1 Q9JJP2 Q9WUJ0 Tp73 Trp73 uc008wbg.1 uc008wbg.2 uc008wbg.3 uc008wbg.4 This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008]. Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression, essential for the positive regulation of lung ciliated cell differentiation (PubMed:26947080). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Interacts with HECW2, HIPK2, RANBP9 and WWOX (By similarity). Interacts (via SAM domain) with FBXO45 (via B30.2/SPRY domain) (By similarity). Interacts with YAP1 (phosphorylated form) (By similarity). Interacts with HCK (via SH3 domain); this inhibits TP73 activity and degradation (By similarity). Interacts (via SAM domain) with NQO1; this interaction is NADH-dependent, stabilizes TP73 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome. Q9JJP2; P46938: Yap1; NbExp=2; IntAct=EBI-1770138, EBI-1211949; Nucleus Cytoplasm Note=Accumulates in the nucleus in response to DNA damage. Event=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=1 ; Synonyms=Alpha ; IsoId=Q9JJP2-1; Sequence=Displayed; Name=2 ; Synonyms=dN-Alpha ; IsoId=Q9JJP2-2; Sequence=VSP_053081; Name=3; IsoId=Q9JJP2-3; Sequence=VSP_053081, VSP_053083, VSP_053084; Name=4 ; IsoId=Q9JJP2-4; Sequence=VSP_053081, VSP_053082; Found in striatal neurons of mutant huntingtin (htt) transgenic mice (at protein level). Isoform 1 is expressed in the nasal epithelium, the vomeronasal organ, the hippocampus and the hypothalamus. Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL1 tyrosine kinase SH3 domain. The PPxY motif mediates interaction with WWOX. Sumoylated on Lys-622, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function (By similarity). Higher levels of phosphorylation seen in striatal neurons of. mutant huntingtin (htt) transgenic mice. Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome. Mice lacking Tp73 display a runting phenotype and high rates of mortality due to massive gastrointestinal hemorrhages or intracranial bleeding. The gastrointestinal tract suffers loss of enterocytes and excessive mucosecretions in the duodenum, ileum and cecum. Survivors exhibit hippocampal dysgenesis, hydrocephalus, chronic infections and inflammation, as well as abnormalities in pheromone sensory pathways. Activated and stabilized by interaction with RANBP9. [Isoform 2]: Produced by alternative promoter usage. [Isoform 3]: Produced by alternative splicing of isoform 2. [Isoform 4]: Produced by alternative splicing of isoform 2. Belongs to the p53 family. Sequence=CAM18775.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; activation of MAPK activity chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding release of cytochrome c from mitochondria p53 binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm Golgi apparatus regulation of transcription, DNA-templated apoptotic process inflammatory response cellular response to DNA damage stimulus cell cycle cell cycle arrest regulation of mitotic cell cycle transcription factor binding negative regulation of cell proliferation post-embryonic development regulation of gene expression protein kinase binding hippocampus development cell junction forebrain development cerebrospinal fluid secretion intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator identical protein binding positive regulation of apoptotic process intracellular membrane-bounded organelle negative regulation of JUN kinase activity regulation of neuron apoptotic process negative regulation of neuron apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of neuron differentiation positive regulation of cell size positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding digestive tract morphogenesis neuron development positive regulation of oligodendrocyte differentiation protein tetramerization negative regulation of cardiac muscle cell proliferation positive regulation of cell cycle arrest MDM2/MDM4 family protein binding positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic signaling pathway uc008wbg.1 uc008wbg.2 uc008wbg.3 uc008wbg.4 
ENSMUST00000133534.3 Gm14091 ENSMUST00000133534.3 Gm14091 (from geneSymbol) ENSMUST00000133534.1 ENSMUST00000133534.2 uc289zmy.1 uc289zmy.2 uc289zmy.3 uc289zmy.1 uc289zmy.2 uc289zmy.3 
ENSMUST00000133586.2 Bcas1os1 ENSMUST00000133586.2 Bcas1os1 (from geneSymbol) AK042948 ENSMUST00000133586.1 uc290cwp.1 uc290cwp.2 uc290cwp.1 uc290cwp.2 
ENSMUST00000133595.9 Jmjd8 ENSMUST00000133595.9 jumonji domain containing 8 (from RefSeq NM_028101.5) A0A3B2W707 ENSMUST00000133595.1 ENSMUST00000133595.2 ENSMUST00000133595.3 ENSMUST00000133595.4 ENSMUST00000133595.5 ENSMUST00000133595.6 ENSMUST00000133595.7 ENSMUST00000133595.8 JMJD8_MOUSE Jmjd8 NM_028101 Q3TA59 Q3U1Q1 Q91XD9 Q9D0L5 uc289ikx.1 uc289ikx.2 uc289ikx.3 Functions as a positive regulator of TNF-induced NF-kappaB signaling (By similarity). Regulates angiogenesis and cellular metabolism through interaction with PKM (PubMed:27199445). Oligomer. Dimer. Interacts with PKM; regulates angiogenesis and metabolism. Endoplasmic reticulum lumen Cytoplasm Up-regulated upon endothelial differentiation. N-glycosylated. Homozygote knockout Jmjd8 show no obvious phenotype. However, the number of capillaries in muscle tissue is significantly reduced. Sequence=AAH10800.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB27534.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE28331.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE33443.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE42811.1; Type=Frameshift; Evidence=; molecular_function nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum lumen regulation of glycolytic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of pyruvate kinase activity positive regulation of sprouting angiogenesis uc289ikx.1 uc289ikx.2 uc289ikx.3 
ENSMUST00000133596.3 Gm13565 ENSMUST00000133596.3 Gm13565 (from geneSymbol) AK145669 ENSMUST00000133596.1 ENSMUST00000133596.2 uc289wks.1 uc289wks.2 uc289wks.3 uc289wks.1 uc289wks.2 uc289wks.3 
ENSMUST00000133630.8 R74862 ENSMUST00000133630.8 expressed sequence R74862, transcript variant 1 (from RefSeq NR_110354.1) ENSMUST00000133630.1 ENSMUST00000133630.2 ENSMUST00000133630.3 ENSMUST00000133630.4 ENSMUST00000133630.5 ENSMUST00000133630.6 ENSMUST00000133630.7 NR_110354 uc009kos.1 uc009kos.2 uc009kos.3 uc009kos.4 uc009kos.5 uc009kos.1 uc009kos.2 uc009kos.3 uc009kos.4 uc009kos.5 
ENSMUST00000133653.2 Gm15462 ENSMUST00000133653.2 predicted gene 15462 (from RefSeq NR_166116.1) ENSMUST00000133653.1 NR_166116 uc290ehq.1 uc290ehq.2 uc290ehq.1 uc290ehq.2 
ENSMUST00000133698.3 Gm15755 ENSMUST00000133698.3 Gm15755 (from geneSymbol) ENSMUST00000133698.1 ENSMUST00000133698.2 uc287ymn.1 uc287ymn.2 uc287ymn.3 uc287ymn.1 uc287ymn.2 uc287ymn.3 
ENSMUST00000133723.2 Gm15050 ENSMUST00000133723.2 predicted gene 15050 (from RefSeq NR_152256.1) ENSMUST00000133723.1 NR_152256 uc009byc.1 uc009byc.2 uc009byc.3 uc009byc.4 uc009byc.1 uc009byc.2 uc009byc.3 uc009byc.4 
ENSMUST00000133751.2 Gm14170 ENSMUST00000133751.2 Gm14170 (from geneSymbol) ENSMUST00000133751.1 uc290bxs.1 uc290bxs.2 uc290bxs.1 uc290bxs.2 
ENSMUST00000133752.3 4930512H18Rik ENSMUST00000133752.3 RIKEN cDNA 4930512H18 gene (from RefSeq NR_190142.1) ENSMUST00000133752.1 ENSMUST00000133752.2 NR_190142 uc009luj.1 uc009luj.2 uc009luj.3 uc009luj.1 uc009luj.2 uc009luj.3 
ENSMUST00000133794.8 Gm2101 ENSMUST00000133794.8 predicted gene 2101, transcript variant 2 (from RefSeq NR_153317.1) ENSMUST00000133794.1 ENSMUST00000133794.2 ENSMUST00000133794.3 ENSMUST00000133794.4 ENSMUST00000133794.5 ENSMUST00000133794.6 ENSMUST00000133794.7 NR_153317 uc009svr.1 uc009svr.2 uc009svr.1 uc009svr.2 
ENSMUST00000133808.2 Tmem250 ENSMUST00000133808.2 transmembrane protein 250, transcript variant 2 (from RefSeq NM_001256522.1) A0A571BES4 A0A571BES4_MOUSE ENSMUST00000133808.1 NM_001256522 Tmem250 Tmem250-ps uc289ucf.1 uc289ucf.2 uc289ucf.1 uc289ucf.2 
ENSMUST00000133819.3 Gm12064 ENSMUST00000133819.3 Gm12064 (from geneSymbol) ENSMUST00000133819.1 ENSMUST00000133819.2 uc287xar.1 uc287xar.2 uc287xar.3 uc287xar.1 uc287xar.2 uc287xar.3 
ENSMUST00000133843.8 Gm49369 ENSMUST00000133843.8 Reaction=Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.; EC=3.4.23.5; Evidence=; (from UniProt F6Y6L6) AK167698 ENSMUST00000133843.1 ENSMUST00000133843.2 ENSMUST00000133843.3 ENSMUST00000133843.4 ENSMUST00000133843.5 ENSMUST00000133843.6 ENSMUST00000133843.7 F6Y6L6 F6Y6L6_MOUSE Gm49369 uc291xid.1 uc291xid.2 Reaction=Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.; EC=3.4.23.5; Evidence=; Lysosome Belongs to the peptidase A1 family. aspartic-type endopeptidase activity lysosome proteolysis peptidase activity hydrolase activity protein catabolic process uc291xid.1 uc291xid.2 
ENSMUST00000133910.3 Gm15501 ENSMUST00000133910.3 Gm15501 (from geneSymbol) ENSMUST00000133910.1 ENSMUST00000133910.2 uc291ssi.1 uc291ssi.2 uc291ssi.1 uc291ssi.2 
ENSMUST00000133925.8 Terf2 ENSMUST00000133925.8 telomeric repeat binding factor 2, transcript variant 1 (from RefSeq NM_009353.2) D3YZ08 D3YZ08_MOUSE ENSMUST00000133925.1 ENSMUST00000133925.2 ENSMUST00000133925.3 ENSMUST00000133925.4 ENSMUST00000133925.5 ENSMUST00000133925.6 ENSMUST00000133925.7 NM_009353 Terf2 uc009nhb.1 uc009nhb.2 uc009nhb.3 Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Homodimer. Chromosome, telomere Nucleus telomere maintenance chromosome, telomeric region nuclear telomere cap complex nuclear chromosome, telomeric region DNA binding double-stranded telomeric DNA binding telomerase activity nucleus RNA-dependent DNA biosynthetic process cell cycle protein C-terminus binding positive regulation of gene expression negative regulation of gene expression telomere capping nuclear body enzyme binding Mre11 complex telomeric loop formation protection from non-homologous end joining at telomere regulation of telomere maintenance negative regulation of telomere maintenance negative regulation of telomere maintenance via recombination regulation of telomere maintenance via telomerase negative regulation of telomere maintenance via telomerase telomeric DNA binding protein homodimerization activity macromolecular complex binding positive regulation of nitric-oxide synthase activity telomeric D-loop disassembly telosome protein localization to chromosome, telomeric region G-rich strand telomeric DNA binding anterograde axonal transport of messenger ribonucleoprotein complex negative regulation of beta-galactosidase activity axon cytoplasm negative regulation of telomere capping negative regulation of telomere maintenance via telomere lengthening negative regulation of t-circle formation negative regulation of exonuclease activity negative regulation of cellular senescence uc009nhb.1 uc009nhb.2 uc009nhb.3 
ENSMUST00000133931.9 Aknad1 ENSMUST00000133931.9 AKNA domain containing 1 (from RefSeq NM_177859.3) Aknad1 E9Q8N6 E9Q8N6_MOUSE ENSMUST00000133931.1 ENSMUST00000133931.2 ENSMUST00000133931.3 ENSMUST00000133931.4 ENSMUST00000133931.5 ENSMUST00000133931.6 ENSMUST00000133931.7 ENSMUST00000133931.8 NM_177859 uc008qzp.1 uc008qzp.2 uc008qzp.3 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding epithelial to mesenchymal transition molecular_function biological_process positive regulation of transcription from RNA polymerase II promoter uc008qzp.1 uc008qzp.2 uc008qzp.3 
ENSMUST00000133940.2 Gm12205 ENSMUST00000133940.2 Gm12205 (from geneSymbol) ENSMUST00000133940.1 uc287yar.1 uc287yar.2 uc287yar.1 uc287yar.2 
ENSMUST00000133945.2 Platr13 ENSMUST00000133945.2 Platr13 (from geneSymbol) ENSMUST00000133945.1 uc287xlt.1 uc287xlt.2 uc287xlt.1 uc287xlt.2 
ENSMUST00000133960.2 AI838599 ENSMUST00000133960.2 AI838599 (from geneSymbol) AK085606 ENSMUST00000133960.1 uc290kye.1 uc290kye.2 uc290kye.1 uc290kye.2 
ENSMUST00000133981.2 Gm13746 ENSMUST00000133981.2 Gm13746 (from geneSymbol) ENSMUST00000133981.1 uc289wvz.1 uc289wvz.2 uc289wvz.1 uc289wvz.2 
ENSMUST00000133983.8 Dlgap1 ENSMUST00000133983.8 DLG associated protein 1, transcript variant 6 (from RefSeq NM_001347412.1) DLGP1_MOUSE ENSMUST00000133983.1 ENSMUST00000133983.2 ENSMUST00000133983.3 ENSMUST00000133983.4 ENSMUST00000133983.5 ENSMUST00000133983.6 ENSMUST00000133983.7 Gkap Kiaa4162 NM_001347412 Q52KF6 Q5DTK5 Q6P6N4 Q6XBF4 Q8BZL7 Q8BZQ1 Q8C0G0 Q9D415 uc008dld.1 uc008dld.2 uc008dld.3 uc008dld.4 Part of the postsynaptic scaffold in neuronal cells. Interacts with the guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with DYL2 and LRFN1. Interacts with MPP2 (via the SH3-Guanylate kinase-like sub-module) (By similarity). Q9D415; Q80YA9: Cnksr2; NbExp=3; IntAct=EBI-400152, EBI-771429; Q9D415; P35436: Grin2a; NbExp=2; IntAct=EBI-400152, EBI-400115; Q9D415; Q9Z2Y3: Homer1; NbExp=4; IntAct=EBI-400152, EBI-396980; Q9D415; Q4ACU6: Shank3; NbExp=4; IntAct=EBI-400152, EBI-771450; Q9D415; F6SEU4: Syngap1; NbExp=3; IntAct=EBI-400152, EBI-5797569; Cell membrane ; Peripheral membrane protein Postsynaptic density Synapse Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=SAPAP1; IsoId=Q9D415-1; Sequence=Displayed; Name=2; IsoId=Q9D415-2; Sequence=VSP_015409; Name=3; Synonyms=GKAP1a; IsoId=Q9D415-3; Sequence=VSP_015412; Name=4; Synonyms=GKAP1b; IsoId=Q9D415-4; Sequence=VSP_015409, VSP_015413, VSP_015414; Name=5; IsoId=Q9D415-5; Sequence=VSP_015410, VSP_015411; Name=6; IsoId=Q9D415-6; Sequence=VSP_015408; Highest levels in the neocortex, part of the hippocampus, the granule cell layer of the cerebellum, the glomerular layer of the olfactory bulb, the inner plexiform layer of the retina, the ventral and dorsal horn of the spinal chord, the neuromuscular junction and the submandibular ganglion. Ubiquitinated by TRIM3; leading to proteasomal degradation. Belongs to the SAPAP family. Sequence=BAD90519.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding plasma membrane chemical synaptic transmission postsynaptic density membrane protein domain specific binding signaling cell junction protein localization to synapse macromolecular complex binding synapse postsynaptic membrane regulation of proteasomal protein catabolic process aggresome assembly structural constituent of postsynaptic density glutamatergic synapse postsynaptic density, intracellular component maintenance of postsynaptic density structure uc008dld.1 uc008dld.2 uc008dld.3 uc008dld.4 
ENSMUST00000134011.4 Or1e18-ps1 ENSMUST00000134011.4 Or1e18-ps1 (from geneSymbol) ENSMUST00000134011.1 ENSMUST00000134011.2 ENSMUST00000134011.3 uc287zze.1 uc287zze.2 uc287zze.1 uc287zze.2 
ENSMUST00000134031.2 Gm42791 ENSMUST00000134031.2 Gm42791 (from geneSymbol) ENSMUST00000134031.1 uc291byp.1 uc291byp.2 uc291byp.1 uc291byp.2 
ENSMUST00000134042.4 H2-Ea ENSMUST00000134042.4 histocompatibility 2, class II antigen E alpha, transcript variant 1, non-coding (from RefSeq NR_164196.1) A0A494B9M4 A0A494B9M4_MOUSE ENSMUST00000134042.1 ENSMUST00000134042.2 ENSMUST00000134042.3 H2-Ea NR_164196 uc289kcv.1 uc289kcv.2 uc289kcv.3 uc289kcv.4 This locus belongs to the class II major histocompatibility complex (MHC) family of genes, which encode immune response (Ia) antigens that function in the T-cell-dependent immune response. This family member has multiple haplotypes, some of which result in the production of an E-alpha subunit that combines with an E-beta subunit to form a functional E complex at the cell surface. Other haplotypes, including that of the reference genome allele, contain mutations and they thus represent polymorphic pseudogenes that do not produce functional products. These mutations include frameshifting indels, nonsense mutations, and deletions of larger regions. The reference genome haplotype contains a deletion at the 5' end of the gene, including the core promoter region and the transcription start site, and therefore no transcripts result from this haplotype. [provided by RefSeq, Aug 2011]. Sequence Note: The C57BL/6J mouse strain which represents the reference genome assembly contains a deletion allele in the 5' end of this gene which likely impedes transcription. In other mouse strains this gene has been shown to undergo transcription and translation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC106107.1, AK158317.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849384 [ECO:0000350] ##Evidence-Data-END## Membrane ; Single- pass type I membrane protein Belongs to the MHC class II family. adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune response membrane integral component of membrane antigen processing and presentation MHC class II protein complex uc289kcv.1 uc289kcv.2 uc289kcv.3 uc289kcv.4 
ENSMUST00000134059.3 Gm13073 ENSMUST00000134059.3 Gm13073 (from geneSymbol) ENSMUST00000134059.1 ENSMUST00000134059.2 uc290rzg.1 uc290rzg.2 uc290rzg.3 uc290rzg.1 uc290rzg.2 uc290rzg.3 
ENSMUST00000134069.2 Gm11738 ENSMUST00000134069.2 predicted gene 11738 (from RefSeq NR_189019.1) ENSMUST00000134069.1 NR_189019 uc288dyp.1 uc288dyp.2 uc288dyp.1 uc288dyp.2 
ENSMUST00000134077.2 Gm20521 ENSMUST00000134077.2 Belongs to the Bcl-2 family. (from UniProt D3Z5F7) AK032172 D3Z5F7 D3Z5F7_MOUSE ENSMUST00000134077.1 Gm20521 Pabpn1 uc288uil.1 uc288uil.2 Belongs to the Bcl-2 family. nucleic acid binding RNA binding mitochondrial outer membrane apoptotic process intrinsic apoptotic signaling pathway in response to DNA damage identical protein binding protein homodimerization activity regulation of apoptotic process negative regulation of apoptotic process protein heterodimerization activity Bcl-2 family protein complex extrinsic apoptotic signaling pathway in absence of ligand disordered domain specific binding positive regulation of polynucleotide adenylyltransferase activity negative regulation of intrinsic apoptotic signaling pathway uc288uil.1 uc288uil.2 
ENSMUST00000134115.8 Cnih4 ENSMUST00000134115.8 cornichon family AMPA receptor auxiliary protein 4 (from RefSeq NM_030131.3) CNIH4_MOUSE ENSMUST00000134115.1 ENSMUST00000134115.2 ENSMUST00000134115.3 ENSMUST00000134115.4 ENSMUST00000134115.5 ENSMUST00000134115.6 ENSMUST00000134115.7 NM_030131 Q3TNM6 Q9CX13 uc007dxe.1 uc007dxe.2 uc007dxe.3 Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. Interacts with Sec23/24 complex components SEC24B and SEC24D (By similarity). Interacts with CCR5 (By similarity). Interacts with ADRB2 in the early secretory pathway (By similarity). Membrane ; Multi-pass membrane protein Endoplasmic reticulum Endoplasmic reticulum-Golgi intermediate compartment Belongs to the cornichon family. endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment ER to Golgi vesicle-mediated transport protein transport membrane integral component of membrane vesicle-mediated transport CCR5 chemokine receptor binding uc007dxe.1 uc007dxe.2 uc007dxe.3 
ENSMUST00000134159.3 Zcchc17 ENSMUST00000134159.3 zinc finger, CCHC domain containing 17, transcript variant 5 (from RefSeq NR_149716.1) ENSMUST00000134159.1 ENSMUST00000134159.2 Ldc4 NR_149716 Ps1d Q9ESX4 ZCC17_MOUSE uc008uze.1 uc008uze.2 uc008uze.3 Interacts with PNN (By similarity). Associates with the 60S ribosomal subunit. Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ESX4-1; Sequence=Displayed; Name=2; IsoId=Q9ESX4-2; Sequence=VSP_015309; Expressed in liver, brain, heart, kidney testis, stomach, small intestine, skin, thymus, uterus, placenta, spleen, lung and skeletal muscle. [Isoform 2]: Less abundant than isoform 1. nucleic acid binding RNA binding nucleus nucleolus zinc ion binding cytosolic large ribosomal subunit metal ion binding uc008uze.1 uc008uze.2 uc008uze.3 
ENSMUST00000134179.8 Tmprss11g ENSMUST00000134179.8 transmembrane protease, serine 11g (from RefSeq NM_177162.4) Desc4 ENSMUST00000134179.1 ENSMUST00000134179.2 ENSMUST00000134179.3 ENSMUST00000134179.4 ENSMUST00000134179.5 ENSMUST00000134179.6 ENSMUST00000134179.7 NM_177162 Q8BZ04 Q8BZ10 TM11G_MOUSE uc008xxr.1 uc008xxr.2 uc008xxr.3 uc008xxr.4 Membrane ; Single-pass type II membrane protein Belongs to the peptidase S1 family. Sequence=BAC29676.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; serine-type endopeptidase activity extracellular region plasma membrane integral component of plasma membrane proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc008xxr.1 uc008xxr.2 uc008xxr.3 uc008xxr.4 
ENSMUST00000134206.2 Gm12701 ENSMUST00000134206.2 Gm12701 (from geneSymbol) ENSMUST00000134206.1 KY468006 uc057lji.1 uc057lji.2 uc057lji.3 uc057lji.1 uc057lji.2 uc057lji.3 
ENSMUST00000134214.3 Gm49450 ENSMUST00000134214.3 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. (from UniProt A0A2R8VHF3) A0A2R8VHF3 A0A2R8VHF3_MOUSE AK164335 ENSMUST00000134214.1 ENSMUST00000134214.2 Gm49450 uc289bdo.1 uc289bdo.2 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Belongs to the tubulin family. nucleotide binding GTPase activity structural constituent of cytoskeleton GTP binding microtubule cytoskeleton organization microtubule-based process uc289bdo.1 uc289bdo.2 
ENSMUST00000134226.2 Gm12590 ENSMUST00000134226.2 Gm12590 (from geneSymbol) ENSMUST00000134226.1 uc288emx.1 uc288emx.2 uc288emx.1 uc288emx.2 
ENSMUST00000134236.4 Gm13067 ENSMUST00000134236.4 Gm13067 (from geneSymbol) ENSMUST00000134236.1 ENSMUST00000134236.2 ENSMUST00000134236.3 uc290rzw.1 uc290rzw.2 uc290rzw.3 uc290rzw.4 uc290rzw.1 uc290rzw.2 uc290rzw.3 uc290rzw.4 
ENSMUST00000134250.2 Gm16048 ENSMUST00000134250.2 Gm16048 (from geneSymbol) ENSMUST00000134250.1 uc290hch.1 uc290hch.2 uc290hch.1 uc290hch.2 
ENSMUST00000134257.8 Slc25a14 ENSMUST00000134257.8 solute carrier family 25 (mitochondrial carrier, brain), member 14, transcript variant 19 (from RefSeq NM_001403265.1) A0A0A0MQJ8 A0A0A0MQJ8_MOUSE ENSMUST00000134257.1 ENSMUST00000134257.2 ENSMUST00000134257.3 ENSMUST00000134257.4 ENSMUST00000134257.5 ENSMUST00000134257.6 ENSMUST00000134257.7 NM_001403265 Slc25a14 uc292oau.1 uc292oau.2 Membrane ; Multi- pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. mitochondrial inner membrane mitochondrial transport membrane integral component of membrane mitochondrial membrane uc292oau.1 uc292oau.2 
ENSMUST00000134264.2 Gm14095 ENSMUST00000134264.2 Gm14095 (from geneSymbol) ENSMUST00000134264.1 uc290ase.1 uc290ase.2 uc290ase.1 uc290ase.2 
ENSMUST00000134284.2 Gm15907 ENSMUST00000134284.2 Gm15907 (from geneSymbol) AK051347 ENSMUST00000134284.1 uc288pev.1 uc288pev.2 uc288pev.1 uc288pev.2 
ENSMUST00000134289.2 Gm11611 ENSMUST00000134289.2 Gm11611 (from geneSymbol) ENSMUST00000134289.1 uc288buv.1 uc288buv.2 uc288buv.1 uc288buv.2 
ENSMUST00000134389.3 4930519G04Rik ENSMUST00000134389.3 4930519G04Rik (from geneSymbol) 4930519G04Rik AK005973 ENSMUST00000134389.1 ENSMUST00000134389.2 Q9DAB8 Q9DAB8_MOUSE uc008zct.1 uc008zct.2 uc008zct.3 molecular_function cellular_component biological_process uc008zct.1 uc008zct.2 uc008zct.3 
ENSMUST00000134391.2 Recql5os1 ENSMUST00000134391.2 Recql5os1 (from geneSymbol) ENSMUST00000134391.1 uc288dpg.1 uc288dpg.2 uc288dpg.1 uc288dpg.2 
ENSMUST00000134409.3 1700128E19Rik ENSMUST00000134409.3 1700128E19Rik (from geneSymbol) AK007309 ENSMUST00000134409.1 ENSMUST00000134409.2 uc291yep.1 uc291yep.2 uc291yep.3 uc291yep.1 uc291yep.2 uc291yep.3 
ENSMUST00000134427.2 Gm11613 ENSMUST00000134427.2 Gm11613 (from geneSymbol) AK052674 ENSMUST00000134427.1 uc007leh.1 uc007leh.2 uc007leh.3 uc007leh.1 uc007leh.2 uc007leh.3 
ENSMUST00000134448.2 Gm15208 ENSMUST00000134448.2 Gm15208 (from geneSymbol) ENSMUST00000134448.1 uc288jav.1 uc288jav.2 uc288jav.1 uc288jav.2 
ENSMUST00000134465.8 Phldb1 ENSMUST00000134465.8 pleckstrin homology like domain, family B, member 1, transcript variant 38 (from RefSeq NM_001413455.1) E9PWB1 E9PWB1_MOUSE ENSMUST00000134465.1 ENSMUST00000134465.2 ENSMUST00000134465.3 ENSMUST00000134465.4 ENSMUST00000134465.5 ENSMUST00000134465.6 ENSMUST00000134465.7 NM_001413455 Phldb1 uc292grg.1 uc292grg.2 uc292grg.1 uc292grg.2 
ENSMUST00000134467.3 Gm15522 ENSMUST00000134467.3 predicted gene 15522 (from RefSeq NR_168516.1) ENSMUST00000134467.1 ENSMUST00000134467.2 NR_168516 uc290usp.1 uc290usp.2 uc290usp.3 uc290usp.1 uc290usp.2 uc290usp.3 
ENSMUST00000134476.3 Gm13599 ENSMUST00000134476.3 Gm13599 (from geneSymbol) AK029730 ENSMUST00000134476.1 ENSMUST00000134476.2 uc289wok.1 uc289wok.2 uc289wok.3 uc289wok.1 uc289wok.2 uc289wok.3 
ENSMUST00000134494.2 Gm12823 ENSMUST00000134494.2 Gm12823 (from geneSymbol) ENSMUST00000134494.1 uc290otr.1 uc290otr.2 uc290otr.1 uc290otr.2 
ENSMUST00000134503.8 Ggt1 ENSMUST00000134503.8 gamma-glutamyltransferase 1, transcript variant 2 (from RefSeq NM_001305992.1) ENSMUST00000134503.1 ENSMUST00000134503.2 ENSMUST00000134503.3 ENSMUST00000134503.4 ENSMUST00000134503.5 ENSMUST00000134503.6 ENSMUST00000134503.7 GGT1_MOUSE Ggt Ggtp NM_001305992 Q60928 uc007fqo.1 uc007fqo.2 uc007fqo.3 uc007fqo.4 uc007fqo.5 This gene encodes gamma-glutamyl transpeptidase, a plasmamembrane-associated enzyme that cleaves the peptide bond between gamma-glutamyl and cysteinyl glycine moieties of glutathione. The encoded protein is autocatalytically processed to generate an enzymatically active heterodimer comprised of heavy and light chains. Mice lacking the encoded protein grow slowly, develop cataracts and have elevated levels of glutathione in plasma and urine. Transgenic overexpression of the encoded protein in mice enhances osteoclastic bone resorption. The mutant alleles termed 'Dwarf grey' and 'Dwarf grey Bayer' in mice are associated with deletions in this gene. A gamma-glutamyl transpeptidase paralog is located adjacent to this gene. Alternative splicing results in multiple transcript variants. Additional transcripts using alternate promoters and differing in 5' UTRs have been described. [provided by RefSeq, Apr 2015]. Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)- docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4 (By similarity). Indirectly regulates multiple aspects of skeletal biology (PubMed:12810527). Reaction=an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]; Xref=Rhea:RHEA:23904, Rhea:RHEA-COMP:9780, Rhea:RHEA-COMP:9795, ChEBI:CHEBI:77644, ChEBI:CHEBI:78597, ChEBI:CHEBI:78599, ChEBI:CHEBI:78608; EC=2.3.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23905; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:23906; Evidence=; Reaction=glutathione + H2O = L-cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:28807, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:57925, ChEBI:CHEBI:61694; EC=3.4.19.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28808; Evidence=; Reaction=an S-substituted glutathione + H2O = an S-substituted L- cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:59468, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:90779, ChEBI:CHEBI:143103; EC=3.4.19.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59469; Evidence=; Reaction=H2O + leukotriene C4 = L-glutamate + leukotriene D4; Xref=Rhea:RHEA:31563, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:57973, ChEBI:CHEBI:63166; EC=3.4.19.14; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31564; Evidence=; Reaction=(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)- docosahexaenoate + H2O = (13R)-S-cysteinylglycyl-(14S)-hydroxy- (4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate; Xref=Rhea:RHEA:53512, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:137407, ChEBI:CHEBI:137408; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53513; Evidence=; Activated by autocatalytic cleavage. Sulfur metabolism; glutathione metabolism. Lipid metabolism; leukotriene D4 biosynthesis. Heterodimer composed of the light and heavy chains. The active site is located in the light chain. Cell membrane ; Single-pass type II membrane protein N-glycosylated on both chains. Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme. Note=Defects in Ggt1 are a cause of glutathionuria, severe growth failure, reduced life spans and infertility. Ggt1-deficient mice have multiple metabolic abnormalities and are dwarf. Some abnormalities can be ameliorated by N-acetylcysteine treatment. Deficient mice have growth retardation, skeletal abnormalities. They are sexually immature, develop cataracts, and have coats with a gray cast. Most die between 10 and 18 weeks. They cannot break down GSH into its constituent amino acids as it passes through the proximal tubules of the kidney. They excrete large amounts of GSH in their urine, leading to a fatal cysteine deficiency. Belongs to the gamma-glutamyltransferase family. peptidyltransferase activity regulation of immune system process extracellular space plasma membrane integral component of plasma membrane translation proteolysis cellular amino acid metabolic process glutamate metabolic process fatty acid metabolic process glutathione metabolic process glutathione biosynthetic process glutathione catabolic process spermatogenesis peptidase activity membrane integral component of membrane transferase activity transferase activity, transferring acyl groups transferase activity, transferring amino-acyl groups hydrolase activity cysteine biosynthetic process peptide modification zymogen activation vesicle response to estradiol response to lipopolysaccharide response to tumor necrosis factor glutathione hydrolase activity regulation of inflammatory response leukotriene D4 biosynthetic process uc007fqo.1 uc007fqo.2 uc007fqo.3 uc007fqo.4 uc007fqo.5 
ENSMUST00000134538.9 Pif1 ENSMUST00000134538.9 PIF1 5'-to-3' DNA helicase, transcript variant 3 (from RefSeq NM_001357527.2) A0A6Q6QXN1 A0A6Q6QXN1_MOUSE ENSMUST00000134538.1 ENSMUST00000134538.2 ENSMUST00000134538.3 ENSMUST00000134538.4 ENSMUST00000134538.5 ENSMUST00000134538.6 ENSMUST00000134538.7 ENSMUST00000134538.8 NM_001357527 PIF1 Pif1 uc009qdp.1 uc009qdp.2 uc009qdp.3 uc009qdp.4 DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Monomer. Interacts with telomerase. Nucleus Mitochondrion Belongs to the helicase family. PIF1 subfamily. uc009qdp.1 uc009qdp.2 uc009qdp.3 uc009qdp.4 
ENSMUST00000134550.3 Prps1l1 ENSMUST00000134550.3 phosphoribosyl pyrophosphate synthetase 1-like 1 (from RefSeq NM_029294.2) ENSMUST00000134550.1 ENSMUST00000134550.2 NM_029294 Prps1l1 Q8C5R8 Q8C5R8_MOUSE uc007nje.1 uc007nje.2 Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. Homodimer. The active form is probably a hexamer composed of 3 homodimers. Belongs to the ribose-phosphate pyrophosphokinase family. magnesium ion binding ribose phosphate diphosphokinase complex ribose phosphate diphosphokinase activity ATP binding cytoplasm 5-phosphoribose 1-diphosphate biosynthetic process purine nucleotide biosynthetic process male gonad development nucleoside metabolic process ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process cellular biosynthetic process uc007nje.1 uc007nje.2 
ENSMUST00000134552.2 Gm15751 ENSMUST00000134552.2 Gm15751 (from geneSymbol) AK049097 ENSMUST00000134552.1 uc290zpu.1 uc290zpu.2 uc290zpu.1 uc290zpu.2 
ENSMUST00000134567.2 Gm11493 ENSMUST00000134567.2 Gm11493 (from geneSymbol) ENSMUST00000134567.1 uc288bhi.1 uc288bhi.2 uc288bhi.1 uc288bhi.2 
ENSMUST00000134586.3 Kcnmb4os1 ENSMUST00000134586.3 potassium large conductance calcium-activated channel, subfamily M, beta member 4, opposite strand 1 (from RefSeq NR_028107.1) ENSMUST00000134586.1 ENSMUST00000134586.2 NR_028107 uc007hbx.1 uc007hbx.2 uc007hbx.3 uc007hbx.4 uc007hbx.1 uc007hbx.2 uc007hbx.3 uc007hbx.4 
ENSMUST00000134649.2 Gm15655 ENSMUST00000134649.2 Gm15655 (from geneSymbol) ENSMUST00000134649.1 uc292diz.1 uc292diz.2 uc292diz.1 uc292diz.2 
ENSMUST00000134652.2 Ttc39d ENSMUST00000134652.2 Belongs to the TTC39 family. (from UniProt Q0VF76) ENSMUST00000134652.1 Q0VF76 Q0VF76_MOUSE Ttc39d uc008dqu.1 uc008dqu.2 uc008dqu.3 uc008dqu.4 Belongs to the TTC39 family. molecular_function cellular_component regulation of cholesterol efflux negative regulation of cholesterol storage cholesterol homeostasis regulation of cholesterol metabolic process uc008dqu.1 uc008dqu.2 uc008dqu.3 uc008dqu.4 
ENSMUST00000134661.8 Knstrn ENSMUST00000134661.8 kinetochore-localized astrin/SPAG5 binding (from RefSeq NM_026412.3) D2Ertd750e ENSMUST00000134661.1 ENSMUST00000134661.2 ENSMUST00000134661.3 ENSMUST00000134661.4 ENSMUST00000134661.5 ENSMUST00000134661.6 ENSMUST00000134661.7 NM_026412 Q8K2D9 Q9D9Z1 SKAP_MOUSE Skap Traf4af1 uc008lst.1 uc008lst.2 uc008lst.3 uc008lst.4 Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus- ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2 (By similarity). Interacts with SPAG5 (By similarity). Directly binds to microtubules, although at relatively low affinity (By similarity). Interacts with CENPE; this interaction greatly favors microtubule-binding (By similarity). Interacts with DSN1/MIS13; leading to localization to kinetochores (By similarity). Interacts with MAPRE1/EB1; leading to localization to the microtubule plus ends (By similarity). Interacts with PRPF19 (By similarity). Interacts with DYNLL1 (By similarity). Interacts with MAP4 (By similarity). Nucleus Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, microtubule organizing center Note=Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore- microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends. The coiled coil regions mediate binding to kinetochores. Sequence=AAH31709.1; Type=Erroneous initiation; Evidence=; mitotic sister chromatid segregation chromosome, centromeric region kinetochore condensed chromosome kinetochore spindle pole protein binding nucleus chromosome cytoplasm cytosol cytoskeleton microtubule cell cycle spindle organization chromosome segregation microtubule cytoskeleton microtubule plus-end cell division regulation of attachment of spindle microtubules to kinetochore mitotic spindle uc008lst.1 uc008lst.2 uc008lst.3 uc008lst.4 
ENSMUST00000134663.2 Myo7b ENSMUST00000134663.2 myosin VIIB (from RefSeq NM_032394.3) B9EHR5 ENSMUST00000134663.1 MYO7B_MOUSE NM_032394 Q571N7 Q8R0U3 Q99MZ6 uc008eix.1 uc008eix.2 uc008eix.3 uc008eix.4 Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli. Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5. Interacts with CDHR2. Interacts with CDHR5. Interacts with USH1C (By similarity). Interacts with ANKS4B; requires initial interaction with USH1C (Probable). Cytoplasm, cytoskeleton Cell projection, microvillus Note=Enriched in the microvilli of the intestinal brush border. Expressed primarily in kidney and intestine. Detected in proximal tubule cells of the kidney and enterocytes of the intestine, specifically the distal tips of apical microvilli on these transporting epithelial cells (at protein level). Detected in intestinal enterocytes at embryonic day 17. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents an unconventional myosin. This protein should not be confused with the conventional myosin-7 (MYH7). nucleotide binding motor activity actin binding ATP binding cytoplasm cytoskeleton microvillus brush border myosin complex cell differentiation cell projection actin filament binding apical cytoplasm brush border assembly uc008eix.1 uc008eix.2 uc008eix.3 uc008eix.4 
ENSMUST00000134690.2 Gm7628 ENSMUST00000134690.2 predicted gene 7628 (from RefSeq NR_168955.1) ENSMUST00000134690.1 NR_168955 uc292lls.1 uc292lls.2 uc292lls.1 uc292lls.2 
ENSMUST00000134692.2 Gm15818 ENSMUST00000134692.2 Gm15818 (from geneSymbol) ENSMUST00000134692.1 uc287gku.1 uc287gku.2 uc287gku.1 uc287gku.2 
ENSMUST00000134703.8 Gm49510 ENSMUST00000134703.8 Gm49510 (from geneSymbol) A0A2R8W6I7 A0A2R8W6I7_MOUSE AK172060 ENSMUST00000134703.1 ENSMUST00000134703.2 ENSMUST00000134703.3 ENSMUST00000134703.4 ENSMUST00000134703.5 ENSMUST00000134703.6 ENSMUST00000134703.7 Gm49510 uc288zmm.1 uc288zmm.2 GTPase activator activity cytoplasm signal transduction positive regulation of GTPase activity uc288zmm.1 uc288zmm.2 
ENSMUST00000134773.4 Or1e27-ps1 ENSMUST00000134773.4 Or1e27-ps1 (from geneSymbol) ENSMUST00000134773.1 ENSMUST00000134773.2 ENSMUST00000134773.3 uc287zzu.1 uc287zzu.2 uc287zzu.1 uc287zzu.2 
ENSMUST00000134794.8 Pter ENSMUST00000134794.8 phosphotriesterase related, transcript variant 2 (from RefSeq NM_008961.3) A2AUR4 A2AUR6 ENSMUST00000134794.1 ENSMUST00000134794.2 ENSMUST00000134794.3 ENSMUST00000134794.4 ENSMUST00000134794.5 ENSMUST00000134794.6 ENSMUST00000134794.7 NM_008961 PTER_MOUSE Q60866 Q8BTA3 uc008iju.1 uc008iju.2 uc008iju.3 uc008iju.4 Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. ; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60866-1; Sequence=Displayed; Name=2; IsoId=Q60866-2; Sequence=VSP_038343, VSP_038344; Expressed in kidney and liver. Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family. zinc ion binding catabolic process hydrolase activity hydrolase activity, acting on ester bonds epithelial cell differentiation metal ion binding uc008iju.1 uc008iju.2 uc008iju.3 uc008iju.4 
ENSMUST00000134795.2 Gm14062 ENSMUST00000134795.2 predicted gene 14062 (from RefSeq NR_166195.1) ENSMUST00000134795.1 NR_166195 uc290awa.1 uc290awa.2 uc290awa.1 uc290awa.2 
ENSMUST00000134799.3 Gm12977 ENSMUST00000134799.3 Gm12977 (from geneSymbol) AK016328 ENSMUST00000134799.1 ENSMUST00000134799.2 uc290qpx.1 uc290qpx.2 uc290qpx.3 uc290qpx.1 uc290qpx.2 uc290qpx.3 
ENSMUST00000134801.2 Gm14066 ENSMUST00000134801.2 Gm14066 (from geneSymbol) AK090153 ENSMUST00000134801.1 uc290awg.1 uc290awg.2 uc290awg.1 uc290awg.2 
ENSMUST00000134825.3 Kcne5 ENSMUST00000134825.3 potassium voltage-gated channel subfamily E regulatory subunit 5 (from RefSeq NM_021487.1) ENSMUST00000134825.1 ENSMUST00000134825.2 KCNE5_MOUSE Kcne1l NM_021487 Q9QZ26 uc009ult.1 uc009ult.2 uc009ult.3 Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta- subunit of the repolarizing cardiac potassium ion channel KCNQ1. Interacts with KCNQ1; impairs KCNQ1 localization in lipid rafts and only conducts current upon strong and continued depolarization. Membrane ; Single- pass type I membrane protein Detected in embryonal dorsal root and nerve ganglia, in the somites and in myoepicardial layer of the developing heart wall. Detected at lower levels in the central nervous system (CNS) and in developing limb. Belongs to the potassium channel KCNE family. voltage-gated potassium channel activity plasma membrane ion transport regulation of heart contraction voltage-gated potassium channel complex potassium channel regulator activity membrane integral component of membrane ion channel binding cardiac muscle contraction regulation of membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane repolarization ventricular cardiac muscle cell action potential voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization membrane repolarization during action potential membrane repolarization during cardiac muscle cell action potential atrial cardiac muscle cell action potential regulation of heart rate by cardiac conduction potassium ion export across plasma membrane membrane repolarization during ventricular cardiac muscle cell action potential regulation of potassium ion transmembrane transport negative regulation of potassium ion transmembrane transport positive regulation of potassium ion transmembrane transport negative regulation of delayed rectifier potassium channel activity negative regulation of potassium ion export across plasma membrane regulation of cation channel activity delayed rectifier potassium channel activity voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization uc009ult.1 uc009ult.2 uc009ult.3 
ENSMUST00000134845.2 B230206H07Rik ENSMUST00000134845.2 B230206H07Rik (from geneSymbol) AK080797 ENSMUST00000134845.1 uc291xcd.1 uc291xcd.2 uc291xcd.1 uc291xcd.2 
ENSMUST00000134911.3 Gm12970 ENSMUST00000134911.3 Gm12970 (from geneSymbol) ENSMUST00000134911.1 ENSMUST00000134911.2 uc290qhj.1 uc290qhj.2 uc290qhj.3 uc290qhj.1 uc290qhj.2 uc290qhj.3 
ENSMUST00000134920.2 Gm16323 ENSMUST00000134920.2 Gm16323 (from geneSymbol) ENSMUST00000134920.1 uc289utk.1 uc289utk.2 uc289utk.1 uc289utk.2 
ENSMUST00000134921.3 C230014O12Rik ENSMUST00000134921.3 RIKEN cDNA C230014O12 gene (from RefSeq NR_130173.1) ENSMUST00000134921.1 ENSMUST00000134921.2 NR_130173 uc008jig.1 uc008jig.2 uc008jig.3 uc008jig.4 uc008jig.5 uc008jig.1 uc008jig.2 uc008jig.3 uc008jig.4 uc008jig.5 
ENSMUST00000134966.2 Gm12668 ENSMUST00000134966.2 Gm12668 (from geneSymbol) ENSMUST00000134966.1 uc290ntl.1 uc290ntl.2 uc290ntl.1 uc290ntl.2 
ENSMUST00000134971.3 Gm12853 ENSMUST00000134971.3 Gm12853 (from geneSymbol) ENSMUST00000134971.1 ENSMUST00000134971.2 uc290pie.1 uc290pie.2 uc290pie.3 uc290pie.1 uc290pie.2 uc290pie.3 
ENSMUST00000134992.2 Gm16618 ENSMUST00000134992.2 predicted gene, 16618 (from RefSeq NR_167658.1) ENSMUST00000134992.1 NR_167658 uc029swn.1 uc029swn.2 uc029swn.1 uc029swn.2 
ENSMUST00000135030.2 Gm11195 ENSMUST00000135030.2 Gm11195 (from geneSymbol) ENSMUST00000135030.1 uc288aol.1 uc288aol.2 uc288aol.1 uc288aol.2 
ENSMUST00000135068.4 Gm15932 ENSMUST00000135068.4 Gm15932 (from geneSymbol) ENSMUST00000135068.1 ENSMUST00000135068.2 ENSMUST00000135068.3 uc288unf.1 uc288unf.2 uc288unf.3 uc288unf.1 uc288unf.2 uc288unf.3 
ENSMUST00000135074.2 Ganc ENSMUST00000135074.2 glucosidase, alpha; neutral C (from RefSeq NM_172672.2) A2AQJ8 A2AQJ8_MOUSE ENSMUST00000135074.1 Ganc NM_172672 uc008lvt.1 uc008lvt.2 uc008lvt.3 uc008lvt.4 Belongs to the glycosyl hydrolase 31 family. catalytic activity hydrolase activity, hydrolyzing O-glycosyl compounds carbohydrate metabolic process metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds carbohydrate binding uc008lvt.1 uc008lvt.2 uc008lvt.3 uc008lvt.4 
ENSMUST00000135086.2 Gm1720 ENSMUST00000135086.2 predicted gene 1720 (from RefSeq NR_046015.1) ENSMUST00000135086.1 NR_046015 uc029xoj.1 uc029xoj.2 uc029xoj.1 uc029xoj.2 
ENSMUST00000135088.9 Ywhaq ENSMUST00000135088.9 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). (from UniProt P68254) 1433T_MOUSE AK012540 ENSMUST00000135088.1 ENSMUST00000135088.2 ENSMUST00000135088.3 ENSMUST00000135088.4 ENSMUST00000135088.5 ENSMUST00000135088.6 ENSMUST00000135088.7 ENSMUST00000135088.8 P35216 P68254 Q3TW69 Q3UJN5 Q5SP76 Q5U423 Q66JR6 uc007ndy.1 uc007ndy.2 uc007ndy.3 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). Homodimer (By similarity). Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with SSH1 (By similarity). Interacts with GAB2. Interacts with RGS7 (phosphorylated form) (By similarity). Interacts with CDK16 (PubMed:9197417). Interacts with the 'Ser-241' phosphorylated form of PDPK1 (By similarity). Interacts with the 'Thr- 369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with SLITRK1 (By similarity). Interacts with RIPOR2 (By similarity). Interacts with INAVA; the interaction increases upon PRR (pattern recognition receptor) stimulation and is required for cellular signaling pathway activation and cytokine secretion (By similarity). Interacts with MARK2, MARK3 and MARK4 (By similarity). Interacts with MEFV (By similarity). P68254; P23242: Gja1; NbExp=3; IntAct=EBI-400675, EBI-298630; P68254; P11688: Itga5; NbExp=2; IntAct=EBI-400675, EBI-6477055; P68254; Q5S006: Lrrk2; NbExp=4; IntAct=EBI-400675, EBI-2693710; Cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P68254-1; Sequence=Displayed; Name=2; IsoId=P68254-2; Sequence=VSP_016340; Belongs to the 14-3-3 family. Sequence=AAH80802.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH85299.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding cytoplasm cytosol protein targeting signal transduction small GTPase mediated signal transduction protein C-terminus binding protein domain specific binding macromolecular complex negative regulation of ion transmembrane transport identical protein binding ion channel binding synapse negative regulation of transcription, DNA-templated protein N-terminus binding 14-3-3 protein binding uc007ndy.1 uc007ndy.2 uc007ndy.3 
ENSMUST00000135091.2 Mtln ENSMUST00000135091.2 mitoregulin (from RefSeq NM_001384135.1) ENSMUST00000135091.1 Lemp MTLN_MOUSE Moxi Mpm Mtln NM_001384135 Q8BT35 Smim37 uc290ahb.1 uc290ahb.2 Positively regulates mitochondrial complex assembly and/or stability (PubMed:29949756). Increases mitochondrial membrane potential while decreasing mitochondrial reactive oxygen species (By similarity). Increases mitochondrial respiration rate (PubMed:31296841). Increased mitochondrial respiratory activity promotes myogenic differentiation which facilitates muscle growth and regeneration (PubMed:31296841, PubMed:32393776). Increases mitochondrial calcium retention capacity (PubMed:29949756). Plays a role in maintenance of cellular lipid composition through its interaction with cytochrome b5 reductase CYB5R3 which is required for mitochondrial respiratory complex I activity (PubMed:30796188). Interacts with the mitochondrial trifunctional enzyme complex (MTE) and enhances fatty acid beta-oxidation (PubMed:29949755, PubMed:32243843). Not required for MTE formation or stability (PubMed:29949755). Modulates triglyceride clearance in adipocytes through its role in regulating fatty acid beta-oxidation and lipolysis (PubMed:32243843). Interacts with mitochondrial trifunctional enzyme, a heterotetrameric complex composed of 2 HADHA subunits and 2 HADHB subunits (PubMed:29949755). Interacts with cytochrome b5 reductase CYB5R3; the interaction is required to maintain cellular lipid composition and leads to stimulation of mitochondrial respiratory complex I activity (PubMed:31296841). Interacts with ATP synthase subunit ATP5F1B/ATP5B (By similarity). Mitochondrion inner membrane ingle-pass membrane protein Note=Preferentially binds to cardiolipin relative to other common cell membrane lipids. Enriched in heart and skeletal muscle (at protein level) (PubMed:29949755, PubMed:29949756, PubMed:31296841). Also enriched in adipose tissue with lower levels detected in liver, pancreas and brain (at protein level) (PubMed:29949756). Higher levels in differentiated myotubes than in satellite cells (PubMed:32393776). Levels increase after birth and remain high at postnatal days 14 and 21. No visible phenotype (PubMed:29949756). Mutants are viable and develop normally with no overt phenotypes later in life (PubMed:29949756). In the fed state, no effect on mitochondrial respiratory activities in cardiac or skeletal muscle fibers but, in fasted mutants, skeletal muscle fibers and left ventricular fibers show significantly lower rates of maximal fatty acid oxidation relative to wild-type controls (PubMed:29949756). Left ventricular fibers also show reduced mitochondrial calcium retention capacity (PubMed:29949756). Aberrant distribution of respiratory chain complex I (CI) with distinct loss of a high-molecular weight supercomplex and concomitant increase in free or disassembled CI-associated complexes (PubMed:29949756). Severely decreased presence of dimers of the mitochondrial 2- oxoglutarate dehydrogenase OGDH and the mitochondrial acyl-CoA dehydrogenase ACAD9 (PubMed:29949756). Significantly altered distribution of the mitochondrial acyl-CoA dehydrogenase ACADVL/VLCAD (PubMed:29949756). Impaired muscle formation, muscle weakness and impaired muscle regeneration due to defects in satellite cell differention (PubMed:32393776). Belongs to the mitoregulin family. mitochondrion mitochondrial inner membrane positive regulation of mitochondrial membrane potential membrane integral component of membrane integral component of mitochondrial inner membrane positive regulation of protein complex assembly positive regulation of sequestering of calcium ion uc290ahb.1 uc290ahb.2 
ENSMUST00000135107.4 Sox3 ENSMUST00000135107.4 SRY (sex determining region Y)-box 3 (from RefSeq NM_009237.3) A2AM37 A2AM37_MOUSE ENSMUST00000135107.1 ENSMUST00000135107.2 ENSMUST00000135107.3 NM_009237 Sox3 uc009vff.1 uc009vff.2 DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated sex determination uc009vff.1 uc009vff.2 
ENSMUST00000135110.2 A730017L22Rik ENSMUST00000135110.2 RIKEN cDNA A730017L22 gene (from RefSeq NR_015523.2) ENSMUST00000135110.1 NR_015523 uc290aok.1 uc290aok.2 uc290aok.1 uc290aok.2 
ENSMUST00000135116.2 Sorbs2os ENSMUST00000135116.2 sorbin and SH3 domain containing 2, opposite strand (from RefSeq NR_045739.1) ENSMUST00000135116.1 NR_045739 uc029wsv.1 uc029wsv.2 uc029wsv.1 uc029wsv.2 
ENSMUST00000135147.4 Gm15486 ENSMUST00000135147.4 predicted gene 15486 (from RefSeq NR_151610.1) ENSMUST00000135147.1 ENSMUST00000135147.2 ENSMUST00000135147.3 NR_151610 uc287mxg.1 uc287mxg.2 uc287mxg.3 uc287mxg.1 uc287mxg.2 uc287mxg.3 
ENSMUST00000135186.3 Gm14027 ENSMUST00000135186.3 Gm14027 (from geneSymbol) ENSMUST00000135186.1 ENSMUST00000135186.2 uc290aiy.1 uc290aiy.2 uc290aiy.3 uc290aiy.1 uc290aiy.2 uc290aiy.3 
ENSMUST00000135192.8 Copa ENSMUST00000135192.8 coatomer protein complex subunit alpha (from RefSeq NM_009938.4) COPA_MOUSE E9Q075 ENSMUST00000135192.1 ENSMUST00000135192.2 ENSMUST00000135192.3 ENSMUST00000135192.4 ENSMUST00000135192.5 ENSMUST00000135192.6 ENSMUST00000135192.7 NM_009938 Q8CIE6 uc007dpn.1 uc007dpn.2 uc007dpn.3 uc007dpn.4 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor (By similarity). Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with SCYL1. Interacts with JAGN1 (By similarity). Interacts with TMEM41B (By similarity). Interacts with SVEP1 (PubMed:36792666). Probably interacts with PEX11A. Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. [Xenin]: Secreted Golgi membrane hormone activity structural molecule activity extracellular region extracellular space cytoplasm Golgi apparatus intracellular protein transport ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER intra-Golgi vesicle-mediated transport signal transduction protein transport membrane vesicle-mediated transport membrane coat COPI vesicle coat pancreatic juice secretion COPI-coated vesicle membrane cytoplasmic vesicle uc007dpn.1 uc007dpn.2 uc007dpn.3 uc007dpn.4 
ENSMUST00000135193.9 Lrch3 ENSMUST00000135193.9 leucine-rich repeats and calponin homology (CH) domain containing 3, transcript variant 4 (from RefSeq NM_001310674.1) E9QAU9 E9QAU9_MOUSE ENSMUST00000135193.1 ENSMUST00000135193.2 ENSMUST00000135193.3 ENSMUST00000135193.4 ENSMUST00000135193.5 ENSMUST00000135193.6 ENSMUST00000135193.7 ENSMUST00000135193.8 Lrch3 NM_001310674 uc057bic.1 uc057bic.2 uc057bic.3 cytosol membrane integral component of membrane septin cytoskeleton organization uc057bic.1 uc057bic.2 uc057bic.3 
ENSMUST00000135197.2 Gm21972 ENSMUST00000135197.2 Gm21972 (from geneSymbol) AK164041 ENSMUST00000135197.1 Gm21972 J3QN38 J3QN38_MOUSE uc287jzi.1 uc287jzi.2 nucleus proteasome regulatory particle, base subcomplex proteasome storage granule proteasome-mediated ubiquitin-dependent protein catabolic process endopeptidase activity uc287jzi.1 uc287jzi.2 
ENSMUST00000135211.8 Tle2 ENSMUST00000135211.8 transducin-like enhancer of split 2, transcript variant 2 (from RefSeq NM_001252401.1) ENSMUST00000135211.1 ENSMUST00000135211.2 ENSMUST00000135211.3 ENSMUST00000135211.4 ENSMUST00000135211.5 ENSMUST00000135211.6 ENSMUST00000135211.7 NM_001252401 Q3UN01 Q3UN01_MOUSE Tle2 uc007gio.1 uc007gio.2 uc007gio.3 uc007gio.4 Nucleus Belongs to the WD repeat Groucho/TLE family. nucleus regulation of transcription, DNA-templated uc007gio.1 uc007gio.2 uc007gio.3 uc007gio.4 
ENSMUST00000135222.9 Etnk2 ENSMUST00000135222.9 ethanolamine kinase 2 (from RefSeq NM_175443.6) A7MCT6 B7ZNN6 D3Z771 EKI2_MOUSE ENSMUST00000135222.1 ENSMUST00000135222.2 ENSMUST00000135222.3 ENSMUST00000135222.4 ENSMUST00000135222.5 ENSMUST00000135222.6 ENSMUST00000135222.7 ENSMUST00000135222.8 NM_175443 Q6XRG2 Tuc1 uc007cqh.1 uc007cqh.2 uc007cqh.3 uc007cqh.4 uc007cqh.5 uc007cqh.6 Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity. Reaction=ATP + ethanolamine = ADP + H(+) + phosphoethanolamine; Xref=Rhea:RHEA:13069, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57603, ChEBI:CHEBI:58190, ChEBI:CHEBI:456216; EC=2.7.1.82; Evidence=; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A7MCT6-1; Sequence=Displayed; Name=2; IsoId=A7MCT6-2; Sequence=VSP_039099; Expressed in testis and liver. Low expression in ovary and kidney. The expression is restricted to the gonads during the sex determination period and throughout embryogenesis. In developing testis, the expression is found only in the Sertoli cells. The expression is strongest at day 11.5, more intense in the testis than the ovary. From 12.5 dpc the expression in the ovary is reduced and disappears. The expression at day 13.5 dpc is restricted to the testis cords. No visible phenotype in adults. No significant effect is seen on liver phospholipid metabolism, neural development, or testicular function. No abnormalities are detected in embryonic and adult testis morphology, differentiation, function, or fertility. PubMed:16861741 shows maternal-specific failure to support late embryonic development, resulting in reduced perinatal size and survival and suggesting compromised placental function. Belongs to the choline/ethanolamine kinase family. According to PubMed:16861741, disruption of the gene causes increased prevalence of placental thrombosis, reduced litter size and increased pup mortality. No such effect was observed by PubMed:18755794. One possible explanation lies in the fact that PubMed:16861741 observed a remarkable 100% survival of control pups and 16% mortality for mutant pups, while PubMed:18755794 observed 16% mortality for both wild-type and mutant pups. According to PubMed:18755794, the construct used in PubMed:16861741 may lead to expression of a truncated transcript that might have deleterious effects. nucleotide binding in utero embryonic development placenta development ethanolamine kinase activity ATP binding cellular_component lipid metabolic process phosphatidylethanolamine biosynthetic process CDP-choline pathway phospholipid biosynthetic process post-embryonic development kinase activity phosphorylation transferase activity multicellular organism growth choline kinase activity uc007cqh.1 uc007cqh.2 uc007cqh.3 uc007cqh.4 uc007cqh.5 uc007cqh.6 
ENSMUST00000135241.8 Vamp4 ENSMUST00000135241.8 vesicle-associated membrane protein 4, transcript variant 4 (from RefSeq NM_001356527.1) ENSMUST00000135241.1 ENSMUST00000135241.2 ENSMUST00000135241.3 ENSMUST00000135241.4 ENSMUST00000135241.5 ENSMUST00000135241.6 ENSMUST00000135241.7 NM_001356527 O70480 Q9D095 VAMP4_MOUSE uc007dgk.1 uc007dgk.2 uc007dgk.3 uc007dgk.4 Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity). Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (PubMed:17159904). Interacts with BAIAP3; this interaction is increased in the presence of calcium (By similarity). Golgi apparatus, trans-Golgi network membrane ; Single-pass type IV membrane protein Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles (By similarity). (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 87-Arg-|-Ser-88 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets. Belongs to the synaptobrevin family. microtubule cytoskeleton organization Golgi apparatus trans-Golgi network synaptic vesicle cell surface membrane integral component of membrane synaptic vesicle to endosome fusion vesicle-mediated transport integral component of synaptic vesicle membrane SNARE complex SNARE complex assembly regulation of Golgi to plasma membrane protein transport Golgi to plasma membrane protein transport phagocytic vesicle cellular response to interferon-gamma Golgi ribbon formation integral component of presynaptic endosome membrane regulation of synaptic vesicle endocytosis toxin transport uc007dgk.1 uc007dgk.2 uc007dgk.3 uc007dgk.4 
ENSMUST00000135268.2 Gm12576 ENSMUST00000135268.2 Gm12576 (from geneSymbol) AK082716 ENSMUST00000135268.1 uc288axt.1 uc288axt.2 uc288axt.1 uc288axt.2 
ENSMUST00000135298.8 Myo9a ENSMUST00000135298.8 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (PubMed:27259756). (from UniProt Q8C170) AK029836 ENSMUST00000135298.1 ENSMUST00000135298.2 ENSMUST00000135298.3 ENSMUST00000135298.4 ENSMUST00000135298.5 ENSMUST00000135298.6 ENSMUST00000135298.7 MYO9A_MOUSE Myr7 Q3TRT5 Q4VBD3 Q80Y92 Q8C0U0 Q8C170 uc292hvt.1 uc292hvt.2 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (PubMed:27259756). Membrane ; Single-pass membrane protein Cytoplasm Synapse Cell projection, growth cone Note=Localized in the cytoplasm of cell bodies, dendrites and axons with occasional hints of an enrichment near the plasma membrane. Localized at the neuromuscular junction (PubMed:27259756). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C170-1; Sequence=Displayed; Name=2; IsoId=Q8C170-2; Sequence=VSP_035161; Expressed in the eye, lung, liver, brain, heart, kidney, skeletal muscle and spleen. No detection was found in liver. In the brain, expressed in the ependymal cells of the third ventricle and the aqueduct (PubMed:19828736). Detected in whole embryos at 7, 11, 15 and 17 dpc. Also present in limb buds from 13.5 dpc. At 16.5 dpc, it is expressed throughout the developing nervous system, eye, inner ear, kidney, thyroid gland and teeth. Phosphorylated by ALPK1 following monosodium urate monohydrate (MSU)-induced inflammation. Knockout mice display retarded growth, a dome- shaped skull, and develop severe hydrocephalus with stenosis and closure of the ventral caudal third ventricle and the aqueduct. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Represents an unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9). Sequence=BAC26164.1; Type=Erroneous initiation; Evidence=; nucleotide binding motor activity actin binding GTPase activator activity ATP binding cytoplasm signal transduction membrane integral component of membrane myosin complex cell junction growth cone cell junction assembly intracellular signal transduction cell projection positive regulation of GTPase activity axonal growth cone establishment of epithelial cell apical/basal polarity synapse metal ion binding uc292hvt.1 uc292hvt.2 
ENSMUST00000135329.2 Gm13658 ENSMUST00000135329.2 RIKEN cDNA 9430019J16 gene (from RefSeq NR_040635.1) ENSMUST00000135329.1 NR_040635 uc289xcg.1 uc289xcg.2 uc289xcg.1 uc289xcg.2 
ENSMUST00000135338.3 Susd5 ENSMUST00000135338.3 sushi domain containing 5 (from RefSeq NM_001101510.1) ENSMUST00000135338.1 ENSMUST00000135338.2 G3UW60 G3UW60_MOUSE NM_001101510 Susd5 uc009rxb.1 uc009rxb.2 uc009rxb.3 uc009rxb.4 Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function hyaluronic acid binding cellular_component cell adhesion Notch signaling pathway membrane integral component of membrane uc009rxb.1 uc009rxb.2 uc009rxb.3 uc009rxb.4 
ENSMUST00000135343.2 Gprin1 ENSMUST00000135343.2 G protein-regulated inducer of neurite outgrowth 1, transcript variant 2 (from RefSeq NM_001316710.2) ENSMUST00000135343.1 GRIN1_MOUSE NM_001316710 Q3UNH4 Q6PGF9 Q9QZY2 uc007qpb.1 uc007qpb.2 uc007qpb.3 May be involved in neurite outgrowth. Interacts with activated forms of GNAI1, GNAO1 and GNAZ. Cell membrane; Lipid-anchor. Cell projection, growth cone Note=Highly enriched in growth cone. Expressed specifically in brain (at protein level). Palmitoylation on Cys-923 and/or Cys-924 is required for membrane targeting. Sequence=AAD55371.1; Type=Erroneous initiation; Evidence=; plasma membrane membrane growth cone neuron projection development cell projection phosphoprotein binding uc007qpb.1 uc007qpb.2 uc007qpb.3 
ENSMUST00000135358.3 Rap1gapos ENSMUST00000135358.3 Rap1gapos (from geneSymbol) ENSMUST00000135358.1 ENSMUST00000135358.2 KY468025 uc290ray.1 uc290ray.2 uc290ray.3 uc290ray.1 uc290ray.2 uc290ray.3 
ENSMUST00000135360.2 A930019D19Rik ENSMUST00000135360.2 RIKEN cDNA A930019D19 gene (from RefSeq NR_040619.1) ENSMUST00000135360.1 NR_040619 uc029ufg.1 uc029ufg.2 uc029ufg.1 uc029ufg.2 
ENSMUST00000135383.9 Engase ENSMUST00000135383.9 endo-beta-N-acetylglucosaminidase, transcript variant 8 (from RefSeq NR_175777.1) ENASE_MOUSE ENSMUST00000135383.1 ENSMUST00000135383.2 ENSMUST00000135383.3 ENSMUST00000135383.4 ENSMUST00000135383.5 ENSMUST00000135383.6 ENSMUST00000135383.7 ENSMUST00000135383.8 NR_175777 Q3TK58 Q8BJF1 Q8BX80 uc007mpi.1 uc007mpi.2 uc007mpi.3 Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol (By similarity). Reaction=an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta- D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl- [protein] + H2O = an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]- beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L- asparaginyl-[protein]; Xref=Rhea:RHEA:73067, Rhea:RHEA-COMP:12603, Rhea:RHEA-COMP:18176, ChEBI:CHEBI:15377, ChEBI:CHEBI:132248, ChEBI:CHEBI:192714, ChEBI:CHEBI:192715; EC=3.2.1.96; Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BX80-1; Sequence=Displayed; Name=2; IsoId=Q8BX80-2; Sequence=VSP_039763, VSP_039764; [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the glycosyl hydrolase 85 family. Sequence=BAC39149.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; cytoplasm cytosol protein deglycosylation metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity uc007mpi.1 uc007mpi.2 uc007mpi.3 
ENSMUST00000135402.4 Bbip1 ENSMUST00000135402.4 BBSome interacting protein 1, transcript variant 2 (from RefSeq NM_001195348.1) Bbip1 ENSMUST00000135402.1 ENSMUST00000135402.2 ENSMUST00000135402.3 J3QMK2 J3QMK2_MOUSE NM_001195348 uc008hxe.1 uc008hxe.2 uc008hxe.3 uc008hxe.4 uc008hxe.5 uc008hxe.6 molecular_function cytoplasm BBSome eating behavior cilium assembly receptor localization to non-motile cilium uc008hxe.1 uc008hxe.2 uc008hxe.3 uc008hxe.4 uc008hxe.5 uc008hxe.6 
ENSMUST00000135406.9 Gm49599 ENSMUST00000135406.9 Gm49599 (from geneSymbol) ENSMUST00000135406.1 ENSMUST00000135406.2 ENSMUST00000135406.3 ENSMUST00000135406.4 ENSMUST00000135406.5 ENSMUST00000135406.6 ENSMUST00000135406.7 ENSMUST00000135406.8 LF200732 uc007zdc.1 uc007zdc.2 uc007zdc.1 uc007zdc.2 
ENSMUST00000135431.8 Lrrc4c ENSMUST00000135431.8 leucine rich repeat containing 4C, transcript variant 6 (from RefSeq NM_001363048.1) ENSMUST00000135431.1 ENSMUST00000135431.2 ENSMUST00000135431.3 ENSMUST00000135431.4 ENSMUST00000135431.5 ENSMUST00000135431.6 ENSMUST00000135431.7 LRC4C_MOUSE NM_001363048 Ngl1 Q505E5 Q8BGH8 Q8C031 uc008lhd.1 uc008lhd.2 uc008lhd.3 uc008lhd.4 May promote neurite outgrowth of developing thalamic neurons. Interacts with NTNG1 and WHRN. Q8C031; Q80VW5: Whrn; NbExp=4; IntAct=EBI-7417983, EBI-7417603; Postsynaptic cell membrane ; Single- pass type I membrane protein. Highly expressed in the developing cerebral cortex and striatum at 14 dpc. The LRR region is both necessary and sufficient for the interaction with NTNG1. protein binding plasma membrane membrane integral component of membrane cell junction synapse postsynaptic membrane regulation of axonogenesis modulation of synaptic transmission cell adhesion molecule binding protein binding involved in cell-cell adhesion glutamatergic synapse integral component of postsynaptic density membrane synaptic membrane adhesion uc008lhd.1 uc008lhd.2 uc008lhd.3 uc008lhd.4 
ENSMUST00000135434.2 Gm15122 ENSMUST00000135434.2 predicted gene 15122 (from RefSeq NR_188931.1) ENSMUST00000135434.1 NR_188931 uc287syw.1 uc287syw.2 uc287syw.1 uc287syw.2 
ENSMUST00000135438.2 Gm14135 ENSMUST00000135438.2 Gm14135 (from geneSymbol) ENSMUST00000135438.1 uc290bem.1 uc290bem.2 uc290bem.1 uc290bem.2 
ENSMUST00000135444.3 4930555B12Rik ENSMUST00000135444.3 RIKEN cDNA 4930555B12 gene (from RefSeq NR_130989.1) ENSMUST00000135444.1 ENSMUST00000135444.2 NR_130989 uc057ass.1 uc057ass.2 uc057ass.3 uc057ass.4 uc057ass.1 uc057ass.2 uc057ass.3 uc057ass.4 
ENSMUST00000135446.8 Uba52 ENSMUST00000135446.8 Cytoplasm Nucleus (from UniProt Q5M9K3) AF118402 ENSMUST00000135446.1 ENSMUST00000135446.2 ENSMUST00000135446.3 ENSMUST00000135446.4 ENSMUST00000135446.5 ENSMUST00000135446.6 ENSMUST00000135446.7 Q5M9K3 Q5M9K3_MOUSE Uba52 uc292aph.1 uc292aph.2 Cytoplasm Nucleus In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family. In the N-terminal section; belongs to the ubiquitin family. structural constituent of ribosome nucleus cytoplasm ribosome translation response to insecticide cytosolic large ribosomal subunit uc292aph.1 uc292aph.2 
ENSMUST00000135451.2 Gm15650 ENSMUST00000135451.2 Gm15650 (from geneSymbol) ENSMUST00000135451.1 uc290uvc.1 uc290uvc.2 uc290uvc.1 uc290uvc.2 
ENSMUST00000135454.8 Czib ENSMUST00000135454.8 CXXC motif containing zinc binding protein, transcript variant 2 (from RefSeq NM_001347160.1) A2A8E3 A2A8E5 CZIB_MOUSE ENSMUST00000135454.1 ENSMUST00000135454.2 ENSMUST00000135454.3 ENSMUST00000135454.4 ENSMUST00000135454.5 ENSMUST00000135454.6 ENSMUST00000135454.7 NM_001347160 Q8BHG2 Q8C7D6 Q9D1H2 Q9DCH5 uc008ual.1 uc008ual.2 uc008ual.3 uc008ual.4 Monomer. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BHG2-1; Sequence=Displayed; Name=2; IsoId=Q8BHG2-2; Sequence=VSP_021888; Name=3; IsoId=Q8BHG2-3; Sequence=VSP_021887; The N-terminal and the C-terminal half of the protein have a very similar 3D-structure, suggesting they arose from duplication. Requires a bound zinc ion for normal folding and solubility. Belongs to the UPF0587 family. biological_process zinc ion binding metal ion binding uc008ual.1 uc008ual.2 uc008ual.3 uc008ual.4 
ENSMUST00000135491.3 Gm15015 ENSMUST00000135491.3 Gm15015 (from geneSymbol) ENSMUST00000135491.1 ENSMUST00000135491.2 uc292qov.1 uc292qov.2 uc292qov.3 uc292qov.1 uc292qov.2 uc292qov.3 
ENSMUST00000135523.5 Sall2 ENSMUST00000135523.5 spalt like transcription factor 2, transcript variant 2 (from RefSeq NM_001244916.1) A0A2I3BQV4 A0A2I3BQV4_MOUSE ENSMUST00000135523.1 ENSMUST00000135523.2 ENSMUST00000135523.3 ENSMUST00000135523.4 NM_001244916 Sall2 uc007tpe.1 uc007tpe.2 uc007tpe.3 uc007tpe.4 Nucleus Belongs to the sal C2H2-type zinc-finger protein family. nucleic acid binding uc007tpe.1 uc007tpe.2 uc007tpe.3 uc007tpe.4 
ENSMUST00000135544.2 Gm15637 ENSMUST00000135544.2 Gm15637 (from geneSymbol) ENSMUST00000135544.1 uc290zie.1 uc290zie.2 uc290zie.1 uc290zie.2 
ENSMUST00000135553.3 Gm12325 ENSMUST00000135553.3 Gm12325 (from geneSymbol) ENSMUST00000135553.1 ENSMUST00000135553.2 uc287zve.1 uc287zve.2 uc287zve.1 uc287zve.2 
ENSMUST00000135573.8 Prdx1 ENSMUST00000135573.8 peroxiredoxin 1 (from RefSeq NM_011034.5) ENSMUST00000135573.1 ENSMUST00000135573.2 ENSMUST00000135573.3 ENSMUST00000135573.4 ENSMUST00000135573.5 ENSMUST00000135573.6 ENSMUST00000135573.7 Msp23 NM_011034 P35700 PRDX1_MOUSE Paga Q3UBV4 Q9CWI2 Tdpx2 uc008uhd.1 uc008uhd.2 uc008uhd.3 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (PubMed:19766572). Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]- disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.24; Evidence=; Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer (By similarity). Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (By similarity). Interacts with SESN1 and SESN2 (By similarity). Interacts with FAM107A (PubMed:21969592). P35700; P35700: Prdx1; NbExp=2; IntAct=EBI-444948, EBI-444948; P35700; Q13043: STK4; Xeno; NbExp=3; IntAct=EBI-444948, EBI-367376; Cytoplasm Found in various tissues; high concentration in liver. By oxidative and sulfhydryl-reactive agents. Phosphorylated on Thr-90 during the M-phase, which leads to a decrease in enzymatic activity. Mice embryos loss approximately 50% of Islet1/Islet2+ and HB9+ motor neurons, whereas dorsal-ventral patterning events and the numbers of Olig2+ progenitors are normal. Toward the end of the cell death phase they have equivalent numbers of motor neurons as wild type embryos. The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin. Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. response to reactive oxygen species peroxidase activity protein binding nucleus nuclear euchromatin nucleolus cytoplasm mitochondrion mitochondrial matrix peroxisomal matrix cytosol response to oxidative stress cell proliferation thioredoxin peroxidase activity antioxidant activity oxidoreductase activity removal of superoxide radicals heme binding natural killer cell activation regulation of stress-activated MAPK cascade erythrocyte homeostasis natural killer cell mediated cytotoxicity hydrogen peroxide catabolic process identical protein binding protein homodimerization activity myelin sheath leukocyte activation cell redox homeostasis peroxiredoxin activity oxidation-reduction process regulation of NIK/NF-kappaB signaling uc008uhd.1 uc008uhd.2 uc008uhd.3 
ENSMUST00000135583.3 Gm16059 ENSMUST00000135583.3 Gm16059 (from geneSymbol) AK035516 ENSMUST00000135583.1 ENSMUST00000135583.2 uc288zqf.1 uc288zqf.2 uc288zqf.1 uc288zqf.2 
ENSMUST00000135630.2 Gm11762 ENSMUST00000135630.2 predicted gene 11762 (from RefSeq NR_045099.1) ENSMUST00000135630.1 NR_045099 uc029rqb.1 uc029rqb.2 uc029rqb.1 uc029rqb.2 
ENSMUST00000135643.8 Tex50 ENSMUST00000135643.8 Tex50 (from geneSymbol) 4930469G21Rik AK015528 ENSMUST00000135643.1 ENSMUST00000135643.2 ENSMUST00000135643.3 ENSMUST00000135643.4 ENSMUST00000135643.5 ENSMUST00000135643.6 ENSMUST00000135643.7 Q9D5B7 Q9D5B7_MOUSE Tex50 uc011wup.1 uc011wup.2 uc011wup.3 membrane integral component of membrane uc011wup.1 uc011wup.2 uc011wup.3 
ENSMUST00000135670.2 9130017K11Rik ENSMUST00000135670.2 9130017K11Rik (from geneSymbol) AK043616 ENSMUST00000135670.1 uc287zcb.1 uc287zcb.2 uc287zcb.1 uc287zcb.2 
ENSMUST00000135671.8 Ndufb2 ENSMUST00000135671.8 NADH:ubiquinone oxidoreductase subunit B2, transcript variant 2 (from RefSeq NM_001358797.1) ENSMUST00000135671.1 ENSMUST00000135671.2 ENSMUST00000135671.3 ENSMUST00000135671.4 ENSMUST00000135671.5 ENSMUST00000135671.6 ENSMUST00000135671.7 NDUB2_MOUSE NM_001358797 Q9CPU2 uc009bmd.1 uc009bmd.2 uc009bmd.3 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the complex I NDUFB2 subunit family. molecular_function mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc009bmd.1 uc009bmd.2 uc009bmd.3 
ENSMUST00000135673.9 Pogk ENSMUST00000135673.9 Nucleus (from UniProt Q80TC5) BC072587 ENSMUST00000135673.1 ENSMUST00000135673.2 ENSMUST00000135673.3 ENSMUST00000135673.4 ENSMUST00000135673.5 ENSMUST00000135673.6 ENSMUST00000135673.7 ENSMUST00000135673.8 Kiaa1513 POGK_MOUSE Q80TC5 Q8BPJ3 Q8C887 uc287nmz.1 uc287nmz.2 uc287nmz.3 Nucleus Sequence=BAC33234.1; Type=Erroneous initiation; Evidence=; Sequence=BAC35580.1; Type=Erroneous initiation; Evidence=; Sequence=BAC65802.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding cellular_component nucleus regulation of transcription, DNA-templated multicellular organism development biological_process uc287nmz.1 uc287nmz.2 uc287nmz.3 
ENSMUST00000135674.3 1700084C06Rik ENSMUST00000135674.3 1700084C06Rik (from geneSymbol) AK006986 ENSMUST00000135674.1 ENSMUST00000135674.2 uc292ezh.1 uc292ezh.2 uc292ezh.3 uc292ezh.1 uc292ezh.2 uc292ezh.3 
ENSMUST00000135680.8 Mrps14 ENSMUST00000135680.8 mitochondrial ribosomal protein S14, transcript variant 1 (from RefSeq NM_025474.4) ENSMUST00000135680.1 ENSMUST00000135680.2 ENSMUST00000135680.3 ENSMUST00000135680.4 ENSMUST00000135680.5 ENSMUST00000135680.6 ENSMUST00000135680.7 NM_025474 Q3UNI7 Q9CR88 RT14_MOUSE uc007def.1 uc007def.2 uc007def.3 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins (By similarity). Interacts with LIAT1. Mitochondrion Belongs to the universal ribosomal protein uS14 family. structural constituent of ribosome protein binding mitochondrion mitochondrial small ribosomal subunit ribosome translation mitochondrial translation uc007def.1 uc007def.2 uc007def.3 
ENSMUST00000135687.2 Sertm2 ENSMUST00000135687.2 serine rich and transmembrane domain containing 2 (from RefSeq NM_001354493.1) A0A1B0GSN8 ENSMUST00000135687.1 NM_001354493 SERTM2 SRTM2_MOUSE uc009umr.1 uc009umr.2 uc009umr.3 uc009umr.4 Membrane ; Single-pass membrane protein membrane integral component of membrane uc009umr.1 uc009umr.2 uc009umr.3 uc009umr.4 
ENSMUST00000135700.3 4930527E20Rik ENSMUST00000135700.3 4930527E20Rik (from geneSymbol) AK019703 ENSMUST00000135700.1 ENSMUST00000135700.2 uc289uuo.1 uc289uuo.2 uc289uuo.3 uc289uuo.1 uc289uuo.2 uc289uuo.3 
ENSMUST00000135729.8 Gjd2os ENSMUST00000135729.8 gap junction protein, delta 2 opposite strand (from RefSeq NR_028423.1) ENSMUST00000135729.1 ENSMUST00000135729.2 ENSMUST00000135729.3 ENSMUST00000135729.4 ENSMUST00000135729.5 ENSMUST00000135729.6 ENSMUST00000135729.7 NR_028423 uc008lpv.1 uc008lpv.2 uc008lpv.3 uc008lpv.4 uc008lpv.1 uc008lpv.2 uc008lpv.3 uc008lpv.4 
ENSMUST00000135748.2 Pla2g2a ENSMUST00000135748.2 phospholipase A2, group IIA (platelets, synovial fluid), transcript variant 1, non-coding (from RefSeq NR_002926.3) ENSMUST00000135748.1 NR_002926 uc290rdn.1 uc290rdn.2 Proteins belonging to the phospholipase A2 (PLA2) family hydrolyze phospholipids into sn2 fatty acids and lysophospholipids. They function in a variety of cellular processes, including the digestion of phospholipids and the production of molecules that induce inflammatory responses. This gene encodes a member of the group II class of secretory PLA2s. The secreted enzyme binds to heparin on the cell surface. Mutations in this gene increase the occurrence of intestinal polyps caused by a dominant mutation in the adenomatosis polyposis coli gene. A frameshift inactivates this gene product in some mouse strains including the strain of the reference genome, C57BL/6J, whereas a functional protein is produced in other strains. [provided by RefSeq, Jul 2008]. uc290rdn.1 uc290rdn.2 
ENSMUST00000135767.3 Gm13346 ENSMUST00000135767.3 Gm13346 (from geneSymbol) AK054454 ENSMUST00000135767.1 ENSMUST00000135767.2 uc289tko.1 uc289tko.2 uc289tko.3 uc289tko.1 uc289tko.2 uc289tko.3 
ENSMUST00000135775.8 Gm11961 ENSMUST00000135775.8 predicted gene 11961, transcript variant 1 (from RefSeq NR_027798.2) ENSMUST00000135775.1 ENSMUST00000135775.2 ENSMUST00000135775.3 ENSMUST00000135775.4 ENSMUST00000135775.5 ENSMUST00000135775.6 ENSMUST00000135775.7 NR_027798 uc007huz.1 uc007huz.2 uc007huz.1 uc007huz.2 
ENSMUST00000135792.3 1700092C17Rik ENSMUST00000135792.3 1700092C17Rik (from geneSymbol) AK007039 ENSMUST00000135792.1 ENSMUST00000135792.2 uc289tnf.1 uc289tnf.2 uc289tnf.3 uc289tnf.1 uc289tnf.2 uc289tnf.3 
ENSMUST00000135795.8 Tctn3 ENSMUST00000135795.8 Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation (By similarity). Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway. (from UniProt Q8R2Q6) AK015861 ENSMUST00000135795.1 ENSMUST00000135795.2 ENSMUST00000135795.3 ENSMUST00000135795.4 ENSMUST00000135795.5 ENSMUST00000135795.6 ENSMUST00000135795.7 Q8CDF3 Q8R2Q6 Q9CRC5 TECT3_MOUSE Tect3 uc008hlb.1 uc008hlb.2 uc008hlb.3 Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation (By similarity). Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway. Part of the tectonic-like complex (also named B9 complex). Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R2Q6-1; Sequence=Displayed; Name=2; IsoId=Q8R2Q6-2; Sequence=VSP_017769, VSP_017770; Name=3; IsoId=Q8R2Q6-3; Sequence=VSP_017767, VSP_017768; Belongs to the tectonic family. protein binding nucleus apoptotic process smoothened signaling pathway membrane integral component of membrane cell projection organization positive regulation of apoptotic process cilium assembly uc008hlb.1 uc008hlb.2 uc008hlb.3 
ENSMUST00000135807.2 Epm2aip1 ENSMUST00000135807.2 Interacts with EPM2A. (from UniProt Q8VEH5) AK030084 ENSMUST00000135807.1 EPMIP_MOUSE Kiaa0766 Q80TS4 Q8VEH5 uc009rvs.1 uc009rvs.2 uc009rvs.3 Interacts with EPM2A. Endoplasmic reticulum protein binding nucleus cytoplasm endoplasmic reticulum response to insulin identical protein binding positive regulation of glycogen biosynthetic process cytoplasmic side of endoplasmic reticulum membrane positive regulation of glycogen (starch) synthase activity uc009rvs.1 uc009rvs.2 uc009rvs.3 
ENSMUST00000135808.8 Sfxn4 ENSMUST00000135808.8 sideroflexin 4, transcript variant 5 (from RefSeq NR_189656.1) E9QKN7 ENSMUST00000135808.1 ENSMUST00000135808.2 ENSMUST00000135808.3 ENSMUST00000135808.4 ENSMUST00000135808.5 ENSMUST00000135808.6 ENSMUST00000135808.7 NR_189656 Q5FW99 Q925N1 SFXN4_MOUSE Sfxn4 uc008icc.1 uc008icc.2 uc008icc.3 uc008icc.4 Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity). Mitochondrion inner membrane ; Multi-pass membrane protein Largely restricted to kidney, brain and heart. Belongs to the sideroflexin family. molecular_function mitochondrion mitochondrial inner membrane ion transport amino acid transport biological_process ion transmembrane transporter activity membrane integral component of membrane ion transmembrane transport intracellular membrane-bounded organelle transmembrane transport uc008icc.1 uc008icc.2 uc008icc.3 uc008icc.4 
ENSMUST00000135815.9 Gm12216 ENSMUST00000135815.9 Gm12216 (from geneSymbol) AK138811 ENSMUST00000135815.1 ENSMUST00000135815.2 ENSMUST00000135815.3 ENSMUST00000135815.4 ENSMUST00000135815.5 ENSMUST00000135815.6 ENSMUST00000135815.7 ENSMUST00000135815.8 uc287ydn.1 uc287ydn.2 uc287ydn.3 uc287ydn.1 uc287ydn.2 uc287ydn.3 
ENSMUST00000135829.8 Gm13415 ENSMUST00000135829.8 Gm13415 (from geneSymbol) AK037056 ENSMUST00000135829.1 ENSMUST00000135829.2 ENSMUST00000135829.3 ENSMUST00000135829.4 ENSMUST00000135829.5 ENSMUST00000135829.6 ENSMUST00000135829.7 uc289tqg.1 uc289tqg.2 uc289tqg.1 uc289tqg.2 
ENSMUST00000135846.2 Enpp1 ENSMUST00000135846.2 ectonucleotide pyrophosphatase/phosphodiesterase 1, transcript variant 1 (from RefSeq NM_001308327.1) A0A0R4J1Q7 A0A0R4J1Q7_MOUSE ENSMUST00000135846.1 Enpp1 NM_001308327 uc011xbs.1 uc011xbs.2 uc011xbs.3 uc011xbs.4 This gene encodes a member of the nucleoside pyrophosphatase/phosphodiesterase family of enzymes that catalyzes the hydrolysis of pyrophosphate and phosphodiester bonds in nucleotide triphosphates and oligonucleotides, respectively, to generate nucleoside 5'-monophosphates. The encoded protein is a type II transmembrane glycoprotein that negatively regulates bone mineralization. Mice harboring a nonsense mutation in this gene, termed tiptoe walking (ttw), exhibit ectopic ossification of the spinal ligaments. The encoded protein binds to the insulin receptor, inhibits downstream signaling events and induces insulin resistance and glucose tolerance. This gene is located adjacent to a paralog on chromosome 10. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Secreted Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. nucleic acid binding catalytic activity exonuclease activity phosphodiesterase I activity nucleotide diphosphatase activity scavenger receptor activity insulin receptor binding ATP binding extracellular space plasma membrane generation of precursor metabolites and energy phosphate-containing compound metabolic process endocytosis immune response nucleoside triphosphate catabolic process cell surface membrane integral component of membrane hydrolase activity polysaccharide binding negative regulation of cell growth melanocyte differentiation inorganic diphosphate transport cellular phosphate ion homeostasis sequestering of triglyceride negative regulation of protein autophosphorylation cellular response to insulin stimulus protein homodimerization activity negative regulation of fat cell differentiation negative regulation of glycogen biosynthetic process negative regulation of glucose import negative regulation of insulin receptor signaling pathway metal ion binding nucleoside-triphosphate diphosphatase activity 3'-phosphoadenosine 5'-phosphosulfate metabolic process nucleic acid phosphodiester bond hydrolysis uc011xbs.1 uc011xbs.2 uc011xbs.3 uc011xbs.4 
ENSMUST00000135850.8 Gm49936 ENSMUST00000135850.8 Gm49936 (from geneSymbol) AK012419 ENSMUST00000135850.1 ENSMUST00000135850.2 ENSMUST00000135850.3 ENSMUST00000135850.4 ENSMUST00000135850.5 ENSMUST00000135850.6 ENSMUST00000135850.7 uc289hcx.1 uc289hcx.2 uc289hcx.1 uc289hcx.2 
ENSMUST00000135857.2 Gm11646 ENSMUST00000135857.2 Gm11646 (from geneSymbol) ENSMUST00000135857.1 uc288cyl.1 uc288cyl.2 uc288cyl.1 uc288cyl.2 
ENSMUST00000135858.2 Gm13027 ENSMUST00000135858.2 Gm13027 (from geneSymbol) ENSMUST00000135858.1 uc290rfr.1 uc290rfr.2 uc290rfr.1 uc290rfr.2 
ENSMUST00000135873.2 Gm16075 ENSMUST00000135873.2 Gm16075 (from geneSymbol) ENSMUST00000135873.1 uc288ags.1 uc288ags.2 uc288ags.1 uc288ags.2 
ENSMUST00000135875.4 Or5w1 ENSMUST00000135875.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR43) ENSMUST00000135875.1 ENSMUST00000135875.2 ENSMUST00000135875.3 Olfr1134 Or5w1 Q7TR43 Q7TR43_MOUSE uc033hnx.1 uc033hnx.2 uc033hnx.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033hnx.1 uc033hnx.2 uc033hnx.3 
ENSMUST00000135884.8 Nme1 ENSMUST00000135884.8 NME/NM23 nucleoside diphosphate kinase 1, transcript variant 1 (from RefSeq NM_008704.3) ENSMUST00000135884.1 ENSMUST00000135884.2 ENSMUST00000135884.3 ENSMUST00000135884.4 ENSMUST00000135884.5 ENSMUST00000135884.6 ENSMUST00000135884.7 NM_008704 Nme1 Q5NC81 Q5NC81_MOUSE uc007kxu.1 uc007kxu.2 uc007kxu.3 Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence= Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm Nucleus Belongs to the NDK family. nucleotide binding magnesium ion binding RNA polymerase II regulatory region sequence-specific DNA binding negative regulation of myeloid leukocyte differentiation single-stranded DNA binding deoxyribonuclease activity nucleoside diphosphate kinase activity ATP binding GTP binding nucleus mitochondrial outer membrane centrosome cytosol intermediate filament nucleoside diphosphate phosphorylation GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process DNA metabolic process negative regulation of gene expression positive regulation of neuron projection development response to amine membrane kinase activity phosphorylation transferase activity intermediate filament binding enzyme binding hippocampus development ruffle membrane response to testosterone cellular response to drug response to drug identical protein binding gamma-tubulin binding ribosomal small subunit binding positive regulation of DNA binding perinuclear region of cytoplasm positive regulation of epithelial cell proliferation response to cAMP cellular response to glucose stimulus cellular response to fatty acid uc007kxu.1 uc007kxu.2 uc007kxu.3 
ENSMUST00000135902.2 Gm12910 ENSMUST00000135902.2 Gm12910 (from geneSymbol) ENSMUST00000135902.1 uc290ncg.1 uc290ncg.2 uc290ncg.1 uc290ncg.2 
ENSMUST00000135930.8 Atp8a1 ENSMUST00000135930.8 ATPase phospholipid transporting 8A1, transcript variant 2 (from RefSeq NM_009727.3) AT8A1_MOUSE Atp8a1 Atpc1 ENSMUST00000135930.1 ENSMUST00000135930.2 ENSMUST00000135930.3 ENSMUST00000135930.4 ENSMUST00000135930.5 ENSMUST00000135930.6 ENSMUST00000135930.7 NM_009727 P70704 Q8BR88 uc008xqb.1 uc008xqb.2 uc008xqb.3 uc008xqb.4 Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:20224745, PubMed:16618126). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed:20224745, PubMed:16618126). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (PubMed:23269685). Acts as aminophospholipid translocase at the cell membrane in neuronal cells; the activity is associated with hippocampus-dependent learning (PubMed:22007859). May play a role in brain connectivity (PubMed:27287255). Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38567, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57262, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38568; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; ATPase activity is stimulated by phosphatidylserine (PS) and minimally by phosphatidylethanolamine (PE) (PubMed:16618126, PubMed:20224745). ATPase activity is inhibited by the vanadate and by the presence of calcium (PubMed:20224745). Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (PubMed:23269685). Interacts with TMEM30A to form a flippase complex; this complex forms an intermediate phosphoenzyme (PubMed:23269685). Interacts with TMEM30B; this interaction is reported conflictingly (By similarity). P70704; Q8VEK0: Tmem30a; NbExp=2; IntAct=EBI-20828407, EBI-8381028; Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane ; Multi-pass membrane protein Cytoplasmic granule Cell membrane Endoplasmic reticulum Golgi apparatus Cytoplasmic vesicle Endomembrane system Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures (By similarity). Localizes to plasma membranes of red blood cells (PubMed:16643453). Localizes predominantly in the intracellular membranes, rather than the cell membrane of platelets (PubMed:30674456). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P70704-1; Sequence=Displayed; Name=2; IsoId=P70704-2; Sequence=VSP_055306, VSP_055307; Name=3; IsoId=P70704-3; Sequence=VSP_055307; Found in most tissues except liver and testis. Most abundant in brain and lung. Also detected in fetal tissues. Isoform 1 is expressed in brain. Isoform 2 and isoform 3 are expressed in reticulocytes (PubMed:16643453). Expressed in mouse hippocampus in both dentate gyrus (DG) and the CA3 regions. Expressed in both neuronal as well as non-neuronal cells within the DG (PubMed:27287255). Highly expressed in platelets (PubMed:30674456). Cleaved by calpain in a caspase- and calcium influx-dependent manner only during platelet apoptosis and may lead to inactivation. Mice overexpressing ATP8A1 in brain display an autistic-like behavior but no difference in hippocampus-dependent learning. Unlike the mice overexpressing ATP8A1,homozygous knockout mice for ATP8A1 do not show any deficits in sociability behavior. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. Initial characterization studies with purified Atp8a1 enzyme demonstrated similar but distinct properties compared to the cell membrane aminophospholipid flippase; however, the flippase complex accessory beta subunit was not included in the assays. nucleotide binding magnesium ion binding protein binding ATP binding endoplasmic reticulum Golgi apparatus trans-Golgi network plasma membrane lipid transport learning phospholipid transport membrane integral component of membrane integral component of synaptic vesicle membrane positive regulation of cell migration cytoplasmic vesicle chromaffin granule membrane intracellular membrane-bounded organelle phospholipid translocation metal ion binding positive regulation of phospholipid translocation uc008xqb.1 uc008xqb.2 uc008xqb.3 uc008xqb.4 
ENSMUST00000135941.8 Pfdn2 ENSMUST00000135941.8 prefoldin 2, transcript variant 1 (from RefSeq NM_011070.4) ENSMUST00000135941.1 ENSMUST00000135941.2 ENSMUST00000135941.3 ENSMUST00000135941.4 ENSMUST00000135941.5 ENSMUST00000135941.6 ENSMUST00000135941.7 NM_011070 O70591 PFD2_MOUSE Pfd2 Q8R0H2 uc007doc.1 uc007doc.2 uc007doc.3 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92. Interacts with URI1; the interaction is phosphorylation- dependent and occurs in a growth-dependent manner. Nucleus Cytoplasm Mitochondrion Belongs to the prefoldin subunit beta family. nucleus cytoplasm mitochondrion cytosol protein folding prefoldin complex protein binding involved in protein folding unfolded protein binding positive regulation of cytoskeleton organization uc007doc.1 uc007doc.2 uc007doc.3 
ENSMUST00000135958.2 Lrrc8dos ENSMUST00000135958.2 Lrrc8dos (from geneSymbol) AK015895 ENSMUST00000135958.1 uc290xsy.1 uc290xsy.2 uc290xsy.1 uc290xsy.2 
ENSMUST00000135986.9 Ccdc13 ENSMUST00000135986.9 coiled-coil domain containing 13 (from RefSeq NM_028384.1) CCD13_MOUSE Ccdc13 D3YV10 ENSMUST00000135986.1 ENSMUST00000135986.2 ENSMUST00000135986.3 ENSMUST00000135986.4 ENSMUST00000135986.5 ENSMUST00000135986.6 ENSMUST00000135986.7 ENSMUST00000135986.8 NM_028384 uc012hct.1 uc012hct.2 Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia. Interacts with PCM1, CEP290 and PCNT. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cytoplasm, cytoskeleton, cilium basal body molecular_function nucleus cytoplasm centrosome microtubule organizing center cytosol cytoskeleton cellular response to DNA damage stimulus cell projection organization cytoplasmic microtubule organization centriolar satellite cell projection non-motile cilium assembly uc012hct.1 uc012hct.2 
ENSMUST00000136008.8 Ergic2 ENSMUST00000136008.8 ERGIC and golgi 2, transcript variant 1 (from RefSeq NM_026168.4) B2KFC8 ENSMUST00000136008.1 ENSMUST00000136008.2 ENSMUST00000136008.3 ENSMUST00000136008.4 ENSMUST00000136008.5 ENSMUST00000136008.6 ENSMUST00000136008.7 ERGI2_MOUSE NM_026168 Q3UX13 Q9CR89 Q9CWM6 Q9CYA2 Q9D4R1 Q9D8Z9 uc009etd.1 uc009etd.2 uc009etd.3 Possible role in transport between endoplasmic reticulum and Golgi. May form a heteromeric complex composed of ERGIC1, ERGIC2 and ERGIC3 (By similarity). Interacts with ERGIC3, the interaction is required for the stable expression of both proteins (By similarity). May interact with EEF1A1 (By similarity). Q9CR89; Q9ESF1: Otof; NbExp=3; IntAct=EBI-30868772, EBI-1768732; Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Cytoplasm Nucleus Note=Cycles between the endoplasmic reticulum and the Golgi. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CR89-1; Sequence=Displayed; Name=2; IsoId=Q9CR89-2; Sequence=VSP_019211, VSP_019212; Belongs to the ERGIC family. molecular_function nucleus nucleolus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER membrane integral component of membrane vesicle-mediated transport ER to Golgi transport vesicle integral component of Golgi membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment membrane intracellular membrane-bounded organelle uc009etd.1 uc009etd.2 uc009etd.3 
ENSMUST00000136022.10 ENSMUSG00000121867 ENSMUST00000136022.10 ENSMUSG00000121867 (from geneSymbol) AK008014 ENSMUST00000136022.1 ENSMUST00000136022.2 ENSMUST00000136022.3 ENSMUST00000136022.4 ENSMUST00000136022.5 ENSMUST00000136022.6 ENSMUST00000136022.7 ENSMUST00000136022.8 ENSMUST00000136022.9 uc012eei.1 uc012eei.2 uc012eei.3 uc012eei.4 uc012eei.5 uc012eei.1 uc012eei.2 uc012eei.3 uc012eei.4 uc012eei.5 
ENSMUST00000136026.8 Syce2 ENSMUST00000136026.8 synaptonemal complex central element protein 2, transcript variant 2 (from RefSeq NM_027954.3) Cesc1 ENSMUST00000136026.1 ENSMUST00000136026.2 ENSMUST00000136026.3 ENSMUST00000136026.4 ENSMUST00000136026.5 ENSMUST00000136026.6 ENSMUST00000136026.7 NM_027954 Q3TJR1 Q505B8 Q9DAC4 SYCE2_MOUSE uc009mnv.1 uc009mnv.2 uc009mnv.3 uc009mnv.4 Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:15944401). Requires SYCP1 in order to be incorporated into the central element (PubMed:15944401, PubMed:16968740). May have a role in the synaptonemal complex assembly, stabilization and recombination (PubMed:15944401). Homodimer (PubMed:15944401). Found in a complex with SYCP1 and SYCE1 (PubMed:15944401). Interacts with SYCP1 and SYCE1 (PubMed:15944401). Interacts with SYCE3 (PubMed:21637789). Interacts with TEX12 (PubMed:16968740). Q505B8; B5KM66: Syce3; NbExp=2; IntAct=EBI-6131573, EBI-6128737; Nucleus Chromosome Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE1 in the central elements. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q505B8-1; Sequence=Displayed; Name=2; IsoId=Q505B8-2; Sequence=VSP_021788; Meiotic cells (at protein level). Expressed in the ovary and testis. Expressed in ovary, embryo, spleen, thymus, brain, kidney, epididymis, heart and liver at 14 dpc and in oocytes at 18 dpc. Belongs to the SYCE family. synaptonemal complex central element protein binding nucleus nucleoplasm chromosome cell cycle synaptonemal complex assembly cell division meiotic cell cycle uc009mnv.1 uc009mnv.2 uc009mnv.3 uc009mnv.4 
ENSMUST00000136027.3 Gm14329 ENSMUST00000136027.3 Gm14329 (from geneSymbol) ENSMUST00000136027.1 ENSMUST00000136027.2 uc291jtc.1 uc291jtc.2 uc291jtc.3 uc291jtc.1 uc291jtc.2 uc291jtc.3 
ENSMUST00000136083.3 Gm12119 ENSMUST00000136083.3 Gm12119 (from geneSymbol) ENSMUST00000136083.1 ENSMUST00000136083.2 uc287xjc.1 uc287xjc.2 uc287xjc.3 uc287xjc.1 uc287xjc.2 uc287xjc.3 
ENSMUST00000136115.2 Gm12828 ENSMUST00000136115.2 Gm12828 (from geneSymbol) ENSMUST00000136115.1 uc290pdu.1 uc290pdu.2 uc290pdu.1 uc290pdu.2 
ENSMUST00000136139.8 Gabpb2 ENSMUST00000136139.8 GA repeat binding protein, beta 2, transcript variant 1 (from RefSeq NM_029885.1) A7E218 ENSMUST00000136139.1 ENSMUST00000136139.2 ENSMUST00000136139.3 ENSMUST00000136139.4 ENSMUST00000136139.5 ENSMUST00000136139.6 ENSMUST00000136139.7 GABP2_MOUSE NM_029885 P81069 Q8CDA6 uc008qin.1 uc008qin.2 uc008qin.3 uc008qin.4 Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. Heterotetramer of two alpha and two beta subunits. The C- terminal is necessary for the formation of a heterotetrameric GABP- alpha-2/beta-2 complex, and also facilitates homotypic dimerization. Interacts with ADGRB2 (PubMed:16412436). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P81069-1; Sequence=Displayed; Name=2; IsoId=P81069-2; Sequence=VSP_032473; High levels in thymus, spleen, kidney and intestine. nucleus protein homodimerization activity transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity uc008qin.1 uc008qin.2 uc008qin.3 uc008qin.4 
ENSMUST00000136187.2 Gm54621 ENSMUST00000136187.2 Gm54621 (from geneSymbol) ENSMUST00000136187.1 uc288wqk.1 uc288wqk.2 uc288wqk.1 uc288wqk.2 
ENSMUST00000136190.2 Gm16212 ENSMUST00000136190.2 Gm16212 (from geneSymbol) ENSMUST00000136190.1 uc287rwq.1 uc287rwq.2 uc287rwq.1 uc287rwq.2 
ENSMUST00000136196.3 Kcnab3os ENSMUST00000136196.3 Kcnab3os (from geneSymbol) ENSMUST00000136196.1 ENSMUST00000136196.2 uc287zgk.1 uc287zgk.2 uc287zgk.3 uc287zgk.1 uc287zgk.2 uc287zgk.3 
ENSMUST00000136217.3 Prdm16os ENSMUST00000136217.3 Prdm16 opposite strand transcript (from RefSeq NR_168731.1) ENSMUST00000136217.1 ENSMUST00000136217.2 NR_168731 uc008wbz.1 uc008wbz.2 uc008wbz.3 uc008wbz.1 uc008wbz.2 uc008wbz.3 
ENSMUST00000136302.3 Gm28309 ENSMUST00000136302.3 Gm28309 (from geneSymbol) AK054090 ENSMUST00000136302.1 ENSMUST00000136302.2 uc289xal.1 uc289xal.2 uc289xal.1 uc289xal.2 
ENSMUST00000136305.2 Gm15942 ENSMUST00000136305.2 Gm15942 (from geneSymbol) ENSMUST00000136305.1 uc288xro.1 uc288xro.2 uc288xro.1 uc288xro.2 
ENSMUST00000136313.3 Pramel54 ENSMUST00000136313.3 PRAME like 54, transcript variant 1 (from RefSeq NM_001406248.1) ENSMUST00000136313.1 ENSMUST00000136313.2 K9J7D1 K9J7D1_MOUSE NM_001406248 Pramel53 Pramel54 uc290xgt.1 uc290xgt.2 uc290xgt.3 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xgt.1 uc290xgt.2 uc290xgt.3 
ENSMUST00000136315.2 Gm14273 ENSMUST00000136315.2 predicted gene 14273 (from RefSeq NR_166167.1) ENSMUST00000136315.1 NR_166167 uc290cxj.1 uc290cxj.2 uc290cxj.1 uc290cxj.2 
ENSMUST00000136348.8 Bcorl1 ENSMUST00000136348.8 BCL6 co-repressor-like 1 (from RefSeq NM_178782.4) A2AQH4 BCORL_MOUSE ENSMUST00000136348.1 ENSMUST00000136348.2 ENSMUST00000136348.3 ENSMUST00000136348.4 ENSMUST00000136348.5 ENSMUST00000136348.6 ENSMUST00000136348.7 NM_178782 Q8BMH7 Q8BV26 Q8BW58 uc009tcc.1 uc009tcc.2 uc009tcc.3 Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA- binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor (By similarity). Interacts with PCGF1, forming heterodimers (By similarity). The PCGF1-BCORL1 heterodimeric complex interacts with the KDM2B-SKP1 heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1) (By similarity). Interacts with CTBP1, HDAC4, HDAC5 and HDAC7 (By similarity). Nucleus Belongs to the BCOR family. Sequence=BAC27262.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC27262.1; Type=Frameshift; Evidence=; Sequence=BAC35708.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC38112.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleus nucleoplasm plasma membrane chromatin organization biological_process uc009tcc.1 uc009tcc.2 uc009tcc.3 
ENSMUST00000136371.2 Gm14254 ENSMUST00000136371.2 Gm14254 (from geneSymbol) ENSMUST00000136371.1 uc290chu.1 uc290chu.2 uc290chu.1 uc290chu.2 
ENSMUST00000136376.2 Fbxl12os ENSMUST00000136376.2 F-box and leucine-rich repeat protein 12, opposite strand (from RefSeq NR_033729.1) ENSMUST00000136376.1 NR_033729 uc009oiy.1 uc009oiy.2 uc009oiy.3 uc009oiy.4 uc009oiy.1 uc009oiy.2 uc009oiy.3 uc009oiy.4 
ENSMUST00000136381.8 Sidt1 ENSMUST00000136381.8 SID1 transmembrane family, member 1, transcript variant 2 (from RefSeq NM_198034.3) ENSMUST00000136381.1 ENSMUST00000136381.2 ENSMUST00000136381.3 ENSMUST00000136381.4 ENSMUST00000136381.5 ENSMUST00000136381.6 ENSMUST00000136381.7 NM_198034 Q6AXF6 Q8R397 SIDT1_MOUSE uc007zhd.1 uc007zhd.2 uc007zhd.3 In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp (PubMed:26067272). Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251). Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6AXF6-1; Sequence=Displayed; Name=2; IsoId=Q6AXF6-2; Sequence=VSP_013522; Belongs to the SID1 family. RNA binding double-stranded RNA binding lysosome plasma membrane membrane integral component of membrane dsRNA transport RNA transport RNA transmembrane transporter activity uc007zhd.1 uc007zhd.2 uc007zhd.3 
ENSMUST00000136489.2 Gm13191 ENSMUST00000136489.2 Gm13191 (from geneSymbol) ENSMUST00000136489.1 uc289srd.1 uc289srd.2 uc289srd.1 uc289srd.2 
ENSMUST00000136500.4 Gm11775 ENSMUST00000136500.4 Gm11775 (from geneSymbol) ENSMUST00000136500.1 ENSMUST00000136500.2 ENSMUST00000136500.3 uc288ekt.1 uc288ekt.2 uc288ekt.3 uc288ekt.1 uc288ekt.2 uc288ekt.3 
ENSMUST00000136501.2 Bola3 ENSMUST00000136501.2 bolA family member 3, transcript variant 1 (from RefSeq NM_175277.5) BOLA3_MOUSE ENSMUST00000136501.1 NM_175277 Q8CEI1 uc009cnh.1 uc009cnh.2 uc009cnh.3 Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1. Interacts with NFU1. Mitochondrion Belongs to the BolA/IbaG family. molecular_function mitochondrion biological_process uc009cnh.1 uc009cnh.2 uc009cnh.3 
ENSMUST00000136521.2 Stum ENSMUST00000136521.2 mechanosensory transduction mediator (from RefSeq NM_001081227.2) ENSMUST00000136521.1 NM_001081227 Q0VBF8 STUM_MOUSE Stum uc007dwh.1 uc007dwh.2 uc007dwh.3 uc007dwh.4 Membrane ; Multi-pass membrane protein Able to rescue the walking impairment phenotype when transfected in mutant flies lacking the stum protein (AC Q9W2E1). Belongs to the SPEC3 family. Stum subfamily. molecular_function cellular_component biological_process membrane integral component of membrane uc007dwh.1 uc007dwh.2 uc007dwh.3 uc007dwh.4 
ENSMUST00000136557.2 Gm16068 ENSMUST00000136557.2 Gm16068 (from geneSymbol) ENSMUST00000136557.1 uc289shx.1 uc289shx.2 uc289shx.1 uc289shx.2 
ENSMUST00000136591.8 Dnajc21 ENSMUST00000136591.8 DnaJ heat shock protein family (Hsp40) member C21 (from RefSeq NM_030046.3) DJC21_MOUSE E9Q8D0 ENSMUST00000136591.1 ENSMUST00000136591.2 ENSMUST00000136591.3 ENSMUST00000136591.4 ENSMUST00000136591.5 ENSMUST00000136591.6 ENSMUST00000136591.7 NM_030046 Q3USP3 uc007vgc.1 uc007vgc.2 uc007vgc.3 uc007vgc.4 May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. Interacts with HSPA8, PA2G4 and ZNF622. Cytoplasm Nucleus Nucleus, nucleolus Note=Within the nucleus, localizes primarily to the nucleolus. nucleic acid binding cellular_component nucleus nucleolus cytoplasm biological_process zinc ion binding metal ion binding uc007vgc.1 uc007vgc.2 uc007vgc.3 uc007vgc.4 
ENSMUST00000136628.2 Smim26 ENSMUST00000136628.2 small integral membrane protein 26 (from RefSeq NM_001033297.3) ENSMUST00000136628.1 Gm561 NM_001033297 Q3V460 Q3V460_MOUSE Smim26 uc008mrn.1 uc008mrn.2 uc008mrn.3 molecular_function mitochondrion biological_process uc008mrn.1 uc008mrn.2 uc008mrn.3 
ENSMUST00000136639.2 E330010L02Rik ENSMUST00000136639.2 E330010L02Rik (from geneSymbol) AK087719 ENSMUST00000136639.1 uc009svh.1 uc009svh.2 uc009svh.3 uc009svh.1 uc009svh.2 uc009svh.3 
ENSMUST00000136645.9 Insc ENSMUST00000136645.9 INSC spindle orientation adaptor protein, transcript variant 6 (from RefSeq NR_175961.1) D3Z267 D3Z267_MOUSE ENSMUST00000136645.1 ENSMUST00000136645.2 ENSMUST00000136645.3 ENSMUST00000136645.4 ENSMUST00000136645.5 ENSMUST00000136645.6 ENSMUST00000136645.7 ENSMUST00000136645.8 G3UW77 Insc NR_175961 uc291uqx.1 uc291uqx.2 uc291uqx.3 asymmetric cell division uc291uqx.1 uc291uqx.2 uc291uqx.3 
ENSMUST00000136731.8 Myo5a ENSMUST00000136731.8 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (from UniProt D3YZ62) D3YZ62 D3YZ62_MOUSE ENSMUST00000136731.1 ENSMUST00000136731.2 ENSMUST00000136731.3 ENSMUST00000136731.4 ENSMUST00000136731.5 ENSMUST00000136731.6 ENSMUST00000136731.7 Myo5a X57377 uc292ius.1 uc292ius.2 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. nucleotide binding motor activity actin binding ATP binding myosin complex actin filament binding uc292ius.1 uc292ius.2 
ENSMUST00000136749.2 Gm1698 ENSMUST00000136749.2 Gm1698 (from geneSymbol) AK133405 ENSMUST00000136749.1 uc009liy.1 uc009liy.2 uc009liy.1 uc009liy.2 
ENSMUST00000136755.10 Cspg4b ENSMUST00000136755.10 chondroitin sulfate proteoglycan 4B (from RefSeq NM_001378698.1) BC067074 Cspg4b ENSMUST00000136755.1 ENSMUST00000136755.2 ENSMUST00000136755.3 ENSMUST00000136755.4 ENSMUST00000136755.5 ENSMUST00000136755.6 ENSMUST00000136755.7 ENSMUST00000136755.8 ENSMUST00000136755.9 F6RXI4 F6RXI4_MOUSE NM_001378698 uc007rxf.1 uc007rxf.2 uc007rxf.3 Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function membrane integral component of membrane uc007rxf.1 uc007rxf.2 uc007rxf.3 
ENSMUST00000136757.8 Aamdc ENSMUST00000136757.8 adipogenesis associated Mth938 domain containing, transcript variant 2 (from RefSeq NM_183251.3) AAMDC_MOUSE ENSMUST00000136757.1 ENSMUST00000136757.2 ENSMUST00000136757.3 ENSMUST00000136757.4 ENSMUST00000136757.5 ENSMUST00000136757.6 ENSMUST00000136757.7 NM_183251 Q8BH71 Q8R0P4 uc012fpj.1 uc012fpj.2 May play a role in preadipocyte differentiation and adipogenesis. Cytoplasm Note=Diffuse distribution with some highly concentrated spots around the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R0P4-1; Sequence=Displayed; Name=2; IsoId=Q8R0P4-2; Sequence=VSP_019270; Widely expressed, with high expression in the adipose tissue and skeletal muscle (at protein level). Belongs to the AAMDC family. molecular_function cytoplasm negative regulation of apoptotic process positive regulation of fat cell differentiation positive regulation of transcription from RNA polymerase II promoter uc012fpj.1 uc012fpj.2 
ENSMUST00000136779.2 Gm15261 ENSMUST00000136779.2 Gm15261 (from geneSymbol) AK149393 ENSMUST00000136779.1 uc292rud.1 uc292rud.2 uc292rud.1 uc292rud.2 
ENSMUST00000136783.2 Prn ENSMUST00000136783.2 prion protein readthrough transcript, transcript variant 1 (from RefSeq NM_001278258.1) A0A075B668 A0A075B668_MOUSE ENSMUST00000136783.1 NM_001278258 Prn uc008mmb.1 uc008mmb.2 uc008mmb.3 uc008mmb.4 uc008mmb.5 This locus represents naturally occurring readthrough transcription between the neighboring Prnp (major prion protein) and Prnd (prion-like protein doppel) genes on chromosome 2. The readthrough transcript encodes a protein that shares sequence identity with the downstream gene product but its N-terminal region is distinct due to the presence of an in-frame, upstream AUG compared to the downstream gene. [provided by RefSeq, May 2013]. Cell membrane ; Lipid-anchor, GPI-anchor Membrane ; Lipid-anchor, GPI-anchor Belongs to the prion family. copper ion binding plasma membrane cellular copper ion homeostasis membrane anchored component of external side of plasma membrane metal ion binding protein homooligomerization uc008mmb.1 uc008mmb.2 uc008mmb.3 uc008mmb.4 uc008mmb.5 
ENSMUST00000136806.8 Hoxaas3 ENSMUST00000136806.8 Hoxaas3 (from geneSymbol) AK146012 ENSMUST00000136806.1 ENSMUST00000136806.2 ENSMUST00000136806.3 ENSMUST00000136806.4 ENSMUST00000136806.5 ENSMUST00000136806.6 ENSMUST00000136806.7 uc009bye.1 uc009bye.2 uc009bye.3 uc009bye.4 uc009bye.1 uc009bye.2 uc009bye.3 uc009bye.4 
ENSMUST00000136820.2 Gm11571 ENSMUST00000136820.2 predicted gene 11571 (from RefSeq NR_189031.1) ENSMUST00000136820.1 NR_189031 uc007lke.1 uc007lke.2 uc007lke.1 uc007lke.2 
ENSMUST00000136822.3 B3gnt9 ENSMUST00000136822.3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9, transcript variant 2 (from RefSeq NM_001271915.1) B3GN9_MOUSE B3gnt9 ENSMUST00000136822.1 ENSMUST00000136822.2 NM_001271915 Q8BK98 Q8VI16 uc029wvg.1 uc029wvg.2 uc029wvg.3 Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 31 family. Golgi membrane fibrillar center endoplasmic reticulum Golgi apparatus protein glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups poly-N-acetyllactosamine biosynthetic process uc029wvg.1 uc029wvg.2 uc029wvg.3 
ENSMUST00000136834.3 1700036O09Rik ENSMUST00000136834.3 1700036O09Rik (from geneSymbol) AK006615 ENSMUST00000136834.1 ENSMUST00000136834.2 uc292olk.1 uc292olk.2 uc292olk.3 uc292olk.1 uc292olk.2 uc292olk.3 
ENSMUST00000136860.3 ENSMUSG00000121874 ENSMUST00000136860.3 ENSMUSG00000121874 (from geneSymbol) ENSMUST00000136860.1 ENSMUST00000136860.2 uc292roq.1 uc292roq.2 uc292roq.3 uc292roq.1 uc292roq.2 uc292roq.3 
ENSMUST00000136872.8 Mtch2 ENSMUST00000136872.8 mitochondrial carrier 2, transcript variant 1 (from RefSeq NM_019758.3) ENSMUST00000136872.1 ENSMUST00000136872.2 ENSMUST00000136872.3 ENSMUST00000136872.4 ENSMUST00000136872.5 ENSMUST00000136872.6 ENSMUST00000136872.7 MTCH2_MOUSE Mimp Mtch2 NM_019758 Q3TPS5 Q791V5 Q99LZ6 Q9D060 Q9D7Y2 Q9QZP3 uc008ktn.1 uc008ktn.2 uc008ktn.3 This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]. Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane. Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal- anchored, tail-anchored and multi-pass membrane proteins. Does not mediate insertion of beta-barrel transmembrane proteins (By similarity). Also acts as a receptor for the truncated form of pro- apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (PubMed:20436477, PubMed:26219591, PubMed:26876167, PubMed:30510213). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (PubMed:20436477, PubMed:26219591, PubMed:26876167). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (PubMed:30510213). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (PubMed:26876167, PubMed:28127879). Interacts with p15BID. Mitochondrion outer membrane ; Multi-pass membrane protein Expressed in a wide variety of tissues. Predominant expressed in liver, kidney, heart, skeletal muscle and testis. Mice homozygous for a knockout allele exhibit abnormal mesoderm development, disorganized extraembryonic tissue, lack of amnion and chorion formation, decreased embryo size and lethality at around 7.5 dpc (PubMed:20436477). Conditional knockout in the liver decreases the sensitivity of mice to Fas-induced hepatocellular apoptosis and prevents the recruitment of tBID to liver mitochondria (PubMed:20436477). Conditional knockout in skeletal muscle results in increased mitochondrial mass and metabolism granting protection against diet-induced obesity (PubMed:26876167). Belongs to the mitochondrial carrier (TC 2.A.29) family. molecular_function mitochondrion mitochondrial outer membrane mitochondrial inner membrane lactate metabolic process negative regulation of mitochondrial membrane potential membrane integral component of membrane hematopoietic stem cell migration mitochondrial ATP synthesis coupled electron transport positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of glycolytic process hematopoietic stem cell homeostasis protein localization to mitochondrion cellular response to radiation establishment of protein localization to mitochondrial membrane involved in mitochondrial fission hepatocyte apoptotic process regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage uc008ktn.1 uc008ktn.2 uc008ktn.3 
ENSMUST00000136886.9 Alkbh3os1 ENSMUST00000136886.9 alkB homolog 3, opposite strand 1 (from RefSeq NR_045827.1) ENSMUST00000136886.1 ENSMUST00000136886.2 ENSMUST00000136886.3 ENSMUST00000136886.4 ENSMUST00000136886.5 ENSMUST00000136886.6 ENSMUST00000136886.7 ENSMUST00000136886.8 NR_045827 uc029udl.1 uc029udl.2 uc029udl.3 uc029udl.1 uc029udl.2 uc029udl.3 
ENSMUST00000136906.2 Armh2 ENSMUST00000136906.2 armadillo-like helical domain containing 2 (from RefSeq NM_001370932.1) A0A286YCZ6 A0A286YCZ6_MOUSE Armh2 ENSMUST00000136906.1 NM_001370932 uc007pwf.1 uc007pwf.2 uc007pwf.3 molecular_function cellular_component biological_process uc007pwf.1 uc007pwf.2 uc007pwf.3 
ENSMUST00000136919.3 Gm15407 ENSMUST00000136919.3 Gm15407 (from geneSymbol) ENSMUST00000136919.1 ENSMUST00000136919.2 uc291bxy.1 uc291bxy.2 uc291bxy.1 uc291bxy.2 
ENSMUST00000136923.3 Gm44793 ENSMUST00000136923.3 Gm44793 (from geneSymbol) ENSMUST00000136923.1 ENSMUST00000136923.2 uc057lti.1 uc057lti.2 uc057lti.1 uc057lti.2 
ENSMUST00000136927.3 Gm11714 ENSMUST00000136927.3 predicted gene 11714 (from RefSeq NR_168694.1) ENSMUST00000136927.1 ENSMUST00000136927.2 NR_168694 uc007maq.1 uc007maq.2 uc007maq.3 uc007maq.1 uc007maq.2 uc007maq.3 
ENSMUST00000136948.3 Smim45 ENSMUST00000136948.3 small integral membrane protein 45, transcript variant 2 (from RefSeq NM_001395956.1) 1500009C09Rik D3YWK9 D3YWK9_MOUSE D3YYW9 ENSMUST00000136948.1 ENSMUST00000136948.2 NM_001395956 Smim45 uc289aby.1 uc289aby.2 uc289aby.3 molecular_function cellular_component biological_process membrane integral component of membrane uc289aby.1 uc289aby.2 uc289aby.3 
ENSMUST00000136983.8 Dpf2 ENSMUST00000136983.8 double PHD fingers 2, transcript variant 2 (from RefSeq NM_011262.5) Baf45d ENSMUST00000136983.1 ENSMUST00000136983.2 ENSMUST00000136983.3 ENSMUST00000136983.4 ENSMUST00000136983.5 ENSMUST00000136983.6 ENSMUST00000136983.7 NM_011262 Q3UNP5 Q60663 Q61103 Q9QYA3 REQU_MOUSE Req Ubid4 uc008gfw.1 uc008gfw.2 uc008gfw.3 uc008gfw.4 Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells (PubMed:7961935). Involved in the regulation of non-canonical NF- kappa-B pathway (By similarity). Interacts with the nucleosomes, in particular nucleosomes bearing histone H3 crotonylated at 'Lys-14' (H3K14cr) for which DPF2 has high affinity. Also interacts (via PHD-type zinc finger domains) with histone H3 butyrylated at 'Lys-14' (H3K14bu), histone H3 propionylated at 'Lys-14' (H3K14pr), and histone H3 acetylated at 'Lys- 14' (H3K14ac). Interacts with histone H3 acetylated at 'Lys-9' (H3K9ac), histone H3 di-methylated at 'Lys-9' (H3K9me2), and histone H3 tri-methylated at 'Lys-9' (H3K9me3). Interacts with histone H4 acetylated at 'Lys-12' (H4K12ac). Interacts with histone H4 acetylated at 'Lys-16' (H4K16ac). Interacts with SWI/SNF complex components. Interacts with SMARCA2, SMARCA4, SMARCB1 and SMARCD1. Interacts with SMARCC1, SMARCC2 and ACTL6A. Interacts with RUNX1. Nucleus Cytoplasm In embryo, highest levels are seen in brain, eyes, thymus and olfactory epithelium in nose, whereas several other tissues, including the musculoskeletal system, show moderate expression. In adult, higher expression in testis, medium in thymus and spleen, lower in certain parts of the brain as the hippocampus. No expression in adult heart, lung, liver, duodenum and kidney. Already detected at embryonic day 8.5. Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at 10.5 dpc-16.5 dpc. Belongs to the requiem/DPF family. Sequence=AAA64637.1; Type=Erroneous initiation; Evidence=; Sequence=AAH07188.1; Type=Erroneous initiation; Evidence=; histone acetyltransferase complex nuclear chromatin nucleic acid binding histone acetyltransferase activity nucleus nucleoplasm cytoplasm centrosome cytosol chromatin organization apoptotic process nervous system development histone acetylation histone binding intracellular membrane-bounded organelle negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding lysine-acetylated histone binding nBAF complex negative regulation of myeloid progenitor cell differentiation uc008gfw.1 uc008gfw.2 uc008gfw.3 uc008gfw.4 
ENSMUST00000136988.9 BC021767 ENSMUST00000136988.9 cDNA sequence BC021767 (from RefSeq NR_033629.1) ENSMUST00000136988.1 ENSMUST00000136988.2 ENSMUST00000136988.3 ENSMUST00000136988.4 ENSMUST00000136988.5 ENSMUST00000136988.6 ENSMUST00000136988.7 ENSMUST00000136988.8 NR_033629 uc290hjs.1 uc290hjs.2 uc290hjs.3 uc290hjs.1 uc290hjs.2 uc290hjs.3 
ENSMUST00000136990.3 Emx2os ENSMUST00000136990.3 Emx2 opposite strand/antisense transcript, non-protein coding (from RefSeq NR_002863.2) ENSMUST00000136990.1 ENSMUST00000136990.2 NR_002863 uc012bod.1 uc012bod.2 uc012bod.1 uc012bod.2 
ENSMUST00000136998.3 Nkx2-2os ENSMUST00000136998.3 NK2 homeobox 2, opposite strand (from RefSeq NR_030769.3) ENSMUST00000136998.1 ENSMUST00000136998.2 NR_030769 uc012cfm.1 uc012cfm.2 uc012cfm.1 uc012cfm.2 
ENSMUST00000137035.8 St3gal6 ENSMUST00000137035.8 ST3 beta-galactoside alpha-2,3-sialyltransferase 6, transcript variant 14 (from RefSeq NR_175356.1) ENSMUST00000137035.1 ENSMUST00000137035.2 ENSMUST00000137035.3 ENSMUST00000137035.4 ENSMUST00000137035.5 ENSMUST00000137035.6 ENSMUST00000137035.7 NR_175356 Q3TRN3 Q80UR7 Q8VIB3 Q9WVG2 SIA10_MOUSE Siat10 uc007znt.1 uc007znt.2 uc007znt.3 uc007znt.4 Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity). Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 29 family. Name=Functional Glycomics Gateway - GTase; Note=ST3Gal VI; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_647"; Golgi membrane cellular_component Golgi apparatus cellular protein modification process protein glycosylation glycolipid metabolic process sialyltransferase activity glycolipid biosynthetic process oligosaccharide metabolic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups beta-galactoside alpha-2,3-sialyltransferase activity cellular response to interleukin-6 sialylation uc007znt.1 uc007znt.2 uc007znt.3 uc007znt.4 
ENSMUST00000137088.8 Rfx5 ENSMUST00000137088.8 regulatory factor X, 5 (influences HLA class II expression), transcript variant 1 (from RefSeq NM_017395.4) D3Z1N0 ENSMUST00000137088.1 ENSMUST00000137088.2 ENSMUST00000137088.3 ENSMUST00000137088.4 ENSMUST00000137088.5 ENSMUST00000137088.6 ENSMUST00000137088.7 G3X9S6 NM_017395 Q3U180 Q9JL61 RFX5_MOUSE uc290hky.1 uc290hky.2 Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. Homodimer. The RFX heterotetrameric complex consists of 2 molecules of RFX5 and one each of RFXAP and RFX-B/RFXANK; with each subunit representing a separate complementation group (PubMed:10779326). Interacts (via PxLPxI/L motif) with RFXANK (via ankyrin repeats); the interaction is direct (By similarity). RFX forms cooperative DNA binding complexes with X2BP and CBF/NF-Y. RFX associates with CIITA to form an active transcriptional complex (PubMed:10779326). Nucleus The N-terminus is required for dimer formation, association with RFXANK and RFXAP, assembly of the RFX complex, and for binding of this complex to its X box target site in the MHC-II promoter. The C- terminus mediates cooperative binding between the RFX complex and NF-Y. The PxLPxI/L motif mediates interaction with ankyrin repeats of RFXANK. Phosphorylated. Belongs to the RFX family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc290hky.1 uc290hky.2 
ENSMUST00000137096.2 Gm11186 ENSMUST00000137096.2 predicted gene 11186 (from RefSeq NR_046047.1) ENSMUST00000137096.1 NR_046047 uc029rlq.1 uc029rlq.2 uc029rlq.1 uc029rlq.2 
ENSMUST00000137099.2 Gm15792 ENSMUST00000137099.2 Gm15792 (from geneSymbol) ENSMUST00000137099.1 uc290yey.1 uc290yey.2 uc290yey.1 uc290yey.2 
ENSMUST00000137116.3 Utp23 ENSMUST00000137116.3 UTP23 small subunit processome component (from RefSeq NM_030132.5) ENSMUST00000137116.1 ENSMUST00000137116.2 NM_030132 Q8BY14 Q9CX11 UTP23_MOUSE uc007vrc.1 uc007vrc.2 uc007vrc.3 uc007vrc.4 Involved in rRNA-processing and ribosome biogenesis. Nucleus, nucleolus Belongs to the UTP23/FCF1 family. UTP23 subfamily. endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) mRNA 3'-UTR binding nucleus nucleolus rRNA processing small-subunit processome ribosome biogenesis mRNA 5'-UTR binding small ribosomal subunit rRNA binding uc007vrc.1 uc007vrc.2 uc007vrc.3 uc007vrc.4 
ENSMUST00000137123.3 Gm13872 ENSMUST00000137123.3 Gm13872 (from geneSymbol) AK018918 ENSMUST00000137123.1 ENSMUST00000137123.2 uc289yun.1 uc289yun.2 uc289yun.3 uc289yun.1 uc289yun.2 uc289yun.3 
ENSMUST00000137154.2 Dhx58os ENSMUST00000137154.2 Dhx58os (from geneSymbol) AK053109 ENSMUST00000137154.1 uc007llw.1 uc007llw.2 uc007llw.1 uc007llw.2 
ENSMUST00000137162.8 5330411J11Rik ENSMUST00000137162.8 RIKEN cDNA 5330411J11 gene (from RefSeq NR_040510.1) ENSMUST00000137162.1 ENSMUST00000137162.2 ENSMUST00000137162.3 ENSMUST00000137162.4 ENSMUST00000137162.5 ENSMUST00000137162.6 ENSMUST00000137162.7 NR_040510 uc008jth.1 uc008jth.2 uc008jth.3 uc008jth.4 uc008jth.1 uc008jth.2 uc008jth.3 uc008jth.4 
ENSMUST00000137170.4 Lin52 ENSMUST00000137170.4 lin-52 DREAM MuvB core complex component, transcript variant 1 (from RefSeq NM_173756.5) A0A8Q0Q6C4 A0A8Q0Q6C4_MOUSE ENSMUST00000137170.1 ENSMUST00000137170.2 ENSMUST00000137170.3 Lin52 NM_173756 uc007ofl.1 uc007ofl.2 uc007ofl.3 uc007ofl.4 Belongs to the lin-52 family. uc007ofl.1 uc007ofl.2 uc007ofl.3 uc007ofl.4 
ENSMUST00000137175.3 Gm11657 ENSMUST00000137175.3 Gm11657 (from geneSymbol) ENSMUST00000137175.1 ENSMUST00000137175.2 uc007mbf.1 uc007mbf.2 uc007mbf.3 uc007mbf.4 uc007mbf.1 uc007mbf.2 uc007mbf.3 uc007mbf.4 
ENSMUST00000137186.2 Gm13362 ENSMUST00000137186.2 Gm13362 (from geneSymbol) ENSMUST00000137186.1 uc289tli.1 uc289tli.2 uc289tli.1 uc289tli.2 
ENSMUST00000137193.3 Gm15412 ENSMUST00000137193.3 predicted gene 15412 (from RefSeq NR_046043.1) ENSMUST00000137193.1 ENSMUST00000137193.2 NR_046043 uc029wnb.1 uc029wnb.2 uc029wnb.3 uc029wnb.1 uc029wnb.2 uc029wnb.3 
ENSMUST00000137221.2 Gm13569 ENSMUST00000137221.2 Gm13569 (from geneSymbol) ENSMUST00000137221.1 uc289wli.1 uc289wli.2 uc289wli.1 uc289wli.2 
ENSMUST00000137236.2 Gm12940 ENSMUST00000137236.2 Gm12940 (from geneSymbol) AK031234 ENSMUST00000137236.1 uc008uub.1 uc008uub.2 uc008uub.3 uc008uub.1 uc008uub.2 uc008uub.3 
ENSMUST00000137241.3 4930439A04Rik ENSMUST00000137241.3 4930439A04Rik (from geneSymbol) AK019601 ENSMUST00000137241.1 ENSMUST00000137241.2 uc287hki.1 uc287hki.2 uc287hki.3 uc287hki.1 uc287hki.2 uc287hki.3 
ENSMUST00000137259.2 Gm15918 ENSMUST00000137259.2 Gm15918 (from geneSymbol) ENSMUST00000137259.1 uc288vdo.1 uc288vdo.2 uc288vdo.1 uc288vdo.2 
ENSMUST00000137275.2 Gm14320 ENSMUST00000137275.2 Gm14320 (from geneSymbol) ENSMUST00000137275.1 uc290cto.1 uc290cto.2 uc290cto.1 uc290cto.2 
ENSMUST00000137283.3 Gm13029 ENSMUST00000137283.3 predicted gene 13029 (from RefSeq NR_153821.1) ENSMUST00000137283.1 ENSMUST00000137283.2 NR_153821 uc290rfs.1 uc290rfs.2 uc290rfs.3 uc290rfs.1 uc290rfs.2 uc290rfs.3 
ENSMUST00000137336.3 Ighe ENSMUST00000137336.3 Ighe (from geneSymbol) ENSMUST00000137336.1 ENSMUST00000137336.2 F6W6U3 F6W6U3_MOUSE Ighe LC031494 uc288jrg.1 uc288jrg.2 uc288jrg.1 uc288jrg.2 
ENSMUST00000137349.2 Gm13554 ENSMUST00000137349.2 Gm13554 (from geneSymbol) ENSMUST00000137349.1 uc289uby.1 uc289uby.2 uc289uby.1 uc289uby.2 
ENSMUST00000137359.2 Gm15512 ENSMUST00000137359.2 Gm15512 (from geneSymbol) AK144277 ENSMUST00000137359.1 uc288shw.1 uc288shw.2 uc288shw.1 uc288shw.2 
ENSMUST00000137364.2 Gm12088 ENSMUST00000137364.2 Gm12088 (from geneSymbol) ENSMUST00000137364.1 uc287xed.1 uc287xed.2 uc287xed.1 uc287xed.2 
ENSMUST00000137397.2 Gm13994 ENSMUST00000137397.2 Gm13994 (from geneSymbol) ENSMUST00000137397.1 uc290abz.1 uc290abz.2 uc290abz.1 uc290abz.2 
ENSMUST00000137405.2 2410152P15Rik ENSMUST00000137405.2 2410152P15Rik (from geneSymbol) AK010814 ENSMUST00000137405.1 uc289qoo.1 uc289qoo.2 uc289qoo.1 uc289qoo.2 
ENSMUST00000137411.3 4930507D10Rik ENSMUST00000137411.3 RIKEN cDNA 4930507D10 gene (from RefSeq NR_110449.1) ENSMUST00000137411.1 ENSMUST00000137411.2 NR_110449 uc033fyt.1 uc033fyt.2 uc033fyt.3 uc033fyt.1 uc033fyt.2 uc033fyt.3 
ENSMUST00000137418.2 Gm12273 ENSMUST00000137418.2 Gm12273 (from geneSymbol) AK052659 ENSMUST00000137418.1 uc287yux.1 uc287yux.2 uc287yux.1 uc287yux.2 
ENSMUST00000137462.2 Gm11656 ENSMUST00000137462.2 Gm11656 (from geneSymbol) ENSMUST00000137462.1 uc288ddd.1 uc288ddd.2 uc288ddd.1 uc288ddd.2 
ENSMUST00000137477.2 Gm11267 ENSMUST00000137477.2 Gm11267 (from geneSymbol) AK049966 ENSMUST00000137477.1 uc290nlw.1 uc290nlw.2 uc290nlw.1 uc290nlw.2 
ENSMUST00000137478.4 0610040F04Rik ENSMUST00000137478.4 RIKEN cDNA 0610040F04 gene, transcript variant 1 (from RefSeq NR_104577.1) ENSMUST00000137478.1 ENSMUST00000137478.2 ENSMUST00000137478.3 NR_104577 uc009ddk.1 uc009ddk.2 uc009ddk.3 uc009ddk.4 uc009ddk.1 uc009ddk.2 uc009ddk.3 uc009ddk.4 
ENSMUST00000137496.10 Zfp738 ENSMUST00000137496.10 zinc finger protein 738 (from RefSeq NM_001001187.3) B8JJX8 B8JJX8_MOUSE ENSMUST00000137496.1 ENSMUST00000137496.2 ENSMUST00000137496.3 ENSMUST00000137496.4 ENSMUST00000137496.5 ENSMUST00000137496.6 ENSMUST00000137496.7 ENSMUST00000137496.8 ENSMUST00000137496.9 NM_001001187 Zfp738 uc007rbi.1 uc007rbi.2 uc007rbi.3 uc007rbi.4 nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc007rbi.1 uc007rbi.2 uc007rbi.3 uc007rbi.4 
ENSMUST00000137509.2 Gm12649 ENSMUST00000137509.2 Gm12649 (from geneSymbol) ENSMUST00000137509.1 uc290ntx.1 uc290ntx.2 uc290ntx.1 uc290ntx.2 
ENSMUST00000137532.9 Gm11837 ENSMUST00000137532.9 predicted gene 11837, transcript variant 2 (from RefSeq NM_001356579.1) A0A9L6KDP1 A0A9L6KDP1_MOUSE ENSMUST00000137532.1 ENSMUST00000137532.2 ENSMUST00000137532.3 ENSMUST00000137532.4 ENSMUST00000137532.5 ENSMUST00000137532.6 ENSMUST00000137532.7 ENSMUST00000137532.8 Gm11837 NM_001356579 uc290lhd.1 uc290lhd.2 uc290lhd.3 uc290lhd.1 uc290lhd.2 uc290lhd.3 
ENSMUST00000137535.2 Gm12473 ENSMUST00000137535.2 Gm12473 (from geneSymbol) ENSMUST00000137535.1 uc290mgs.1 uc290mgs.2 uc290mgs.1 uc290mgs.2 
ENSMUST00000137561.3 Gm11659 ENSMUST00000137561.3 Gm11659 (from geneSymbol) ENSMUST00000137561.1 ENSMUST00000137561.2 uc288cvg.1 uc288cvg.2 uc288cvg.3 uc288cvg.1 uc288cvg.2 uc288cvg.3 
ENSMUST00000137564.5 Gm42957 ENSMUST00000137564.5 Gm42957 (from geneSymbol) AK041957 D6RFQ2 D6RFQ2_MOUSE ENSMUST00000137564.1 ENSMUST00000137564.2 ENSMUST00000137564.3 ENSMUST00000137564.4 Gm42957 uc290huz.1 uc290huz.2 peroxisomal membrane integral component of peroxisomal membrane peroxisome fission regulation of peroxisome size uc290huz.1 uc290huz.2 
ENSMUST00000137567.3 Gm12199 ENSMUST00000137567.3 Gm12199 (from geneSymbol) ENSMUST00000137567.1 ENSMUST00000137567.2 uc287xxa.1 uc287xxa.2 uc287xxa.3 uc287xxa.1 uc287xxa.2 uc287xxa.3 
ENSMUST00000137570.2 Gm12830 ENSMUST00000137570.2 predicted gene 12830 (from RefSeq NR_033617.1) ENSMUST00000137570.1 NR_033617 uc290oud.1 uc290oud.2 uc290oud.1 uc290oud.2 
ENSMUST00000137573.2 Zfp866 ENSMUST00000137573.2 zinc finger protein 866 (from RefSeq NM_177899.3) D330038O06Rik D3Z1K0 ENSMUST00000137573.1 NM_177899 Q6PGD2 Q6PGD2_MOUSE Zfp866 uc009lxq.1 uc009lxq.2 uc009lxq.3 nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc009lxq.1 uc009lxq.2 uc009lxq.3 
ENSMUST00000137593.2 Gm11364 ENSMUST00000137593.2 Gm11364 (from geneSymbol) ENSMUST00000137593.1 uc288lrx.1 uc288lrx.2 uc288lrx.1 uc288lrx.2 
ENSMUST00000137598.2 Gm11614 ENSMUST00000137598.2 Gm11614 (from geneSymbol) ENSMUST00000137598.1 uc288bvq.1 uc288bvq.2 uc288bvq.1 uc288bvq.2 
ENSMUST00000137607.3 Gm12843 ENSMUST00000137607.3 Gm12843 (from geneSymbol) ENSMUST00000137607.1 ENSMUST00000137607.2 uc290pdr.1 uc290pdr.2 uc290pdr.3 uc290pdr.1 uc290pdr.2 uc290pdr.3 
ENSMUST00000137613.9 Exoc3l2 ENSMUST00000137613.9 exocyst complex component 3-like 2 (from RefSeq NM_001370800.1) D3YUP5 D3YUP5_MOUSE ENSMUST00000137613.1 ENSMUST00000137613.2 ENSMUST00000137613.3 ENSMUST00000137613.4 ENSMUST00000137613.5 ENSMUST00000137613.6 ENSMUST00000137613.7 ENSMUST00000137613.8 Exoc3l2 NM_001370800 uc291mkc.1 uc291mkc.2 Belongs to the SEC6 family. exocyst SNARE binding in utero embryonic development molecular_function cellular_component exocytosis biological_process exocyst localization uc291mkc.1 uc291mkc.2 
ENSMUST00000137629.2 Gm14342 ENSMUST00000137629.2 predicted gene 14342, transcript variant 1 (from RefSeq NR_190154.1) ENSMUST00000137629.1 NR_190154 uc008okc.1 uc008okc.2 uc008okc.3 uc008okc.1 uc008okc.2 uc008okc.3 
ENSMUST00000137651.2 Gm11300 ENSMUST00000137651.2 Gm11300 (from geneSymbol) ENSMUST00000137651.1 uc288liw.1 uc288liw.2 uc288liw.1 uc288liw.2 
ENSMUST00000137661.2 A230005M16Rik ENSMUST00000137661.2 A230005M16Rik (from geneSymbol) AK082064 ENSMUST00000137661.1 uc012bsf.1 uc012bsf.2 uc012bsf.1 uc012bsf.2 
ENSMUST00000137673.3 Gm15475 ENSMUST00000137673.3 Gm15475 (from geneSymbol) AK043045 ENSMUST00000137673.1 ENSMUST00000137673.2 uc291giy.1 uc291giy.2 uc291giy.1 uc291giy.2 
ENSMUST00000137692.3 Or4a15 ENSMUST00000137692.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AVK5) A2AVK5 A2AVK5_MOUSE ENSMUST00000137692.1 ENSMUST00000137692.2 Olfr1234 Or4a15 uc289yce.1 uc289yce.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yce.1 uc289yce.2 
ENSMUST00000137706.2 Gm10629 ENSMUST00000137706.2 RIKEN cDNA 4930506A18 gene, transcript variant 4 (from RefSeq NR_188809.1) ENSMUST00000137706.1 NR_188809 uc292czl.1 uc292czl.2 uc292czl.1 uc292czl.2 
ENSMUST00000137712.9 Rps6ka6 ENSMUST00000137712.9 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; (from UniProt A2CEE5) A2CEE5 A2CEE5_MOUSE AK049349 ENSMUST00000137712.1 ENSMUST00000137712.2 ENSMUST00000137712.3 ENSMUST00000137712.4 ENSMUST00000137712.5 ENSMUST00000137712.6 ENSMUST00000137712.7 ENSMUST00000137712.8 Rps6ka6 uc292qdq.1 uc292qdq.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation kinase activity phosphorylation transferase activity intracellular signal transduction uc292qdq.1 uc292qdq.2 
ENSMUST00000137714.2 Gm13344 ENSMUST00000137714.2 Gm13344 (from geneSymbol) AB701678 ENSMUST00000137714.1 uc289tki.1 uc289tki.2 uc289tki.1 uc289tki.2 
ENSMUST00000137731.4 Gm15985 ENSMUST00000137731.4 Gm15985 (from geneSymbol) ENSMUST00000137731.1 ENSMUST00000137731.2 ENSMUST00000137731.3 uc290wlc.1 uc290wlc.2 uc290wlc.3 uc290wlc.1 uc290wlc.2 uc290wlc.3 
ENSMUST00000137749.3 Gm11802 ENSMUST00000137749.3 Gm11802 (from geneSymbol) ENSMUST00000137749.1 ENSMUST00000137749.2 uc290lbk.1 uc290lbk.2 uc290lbk.3 uc290lbk.1 uc290lbk.2 uc290lbk.3 
ENSMUST00000137752.2 Gm16023 ENSMUST00000137752.2 predicted gene 16023 (from RefSeq NR_040441.1) ENSMUST00000137752.1 NR_040441 uc008wdy.1 uc008wdy.2 uc008wdy.3 uc008wdy.4 uc008wdy.1 uc008wdy.2 uc008wdy.3 uc008wdy.4 
ENSMUST00000137765.2 Gm14936 ENSMUST00000137765.2 predicted gene 14936 (from RefSeq NR_166839.1) ENSMUST00000137765.1 NR_166839 uc292qew.1 uc292qew.2 uc292qew.1 uc292qew.2 
ENSMUST00000137768.2 Pde6h ENSMUST00000137768.2 phosphodiesterase 6H, cGMP-specific, cone, gamma (from RefSeq NM_023898.4) CNCG_MOUSE ENSMUST00000137768.1 NM_023898 P61249 Q14BP9 Q9D1Y6 Q9EP63 uc009emq.1 uc009emq.2 uc009emq.3 Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones. Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, ChEBI:CHEBI:58115; EC=3.1.4.35; Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). The C-terminal region is important in conferring inhibition. Belongs to the rod/cone cGMP-PDE gamma subunit family. activation of MAPK activity 3',5'-cyclic-nucleotide phosphodiesterase activity visual perception hydrolase activity cGMP binding photoreceptor outer segment membrane positive regulation of epidermal growth factor receptor signaling pathway positive regulation of G-protein coupled receptor protein signaling pathway 3',5'-cyclic-GMP phosphodiesterase activity response to stimulus uc009emq.1 uc009emq.2 uc009emq.3 
ENSMUST00000137780.3 Cnbd1 ENSMUST00000137780.3 cyclic nucleotide binding domain containing 1, transcript variant 1 (from RefSeq NM_001371269.1) B1AWM0 B1AWM0_MOUSE Cnbd1 ENSMUST00000137780.1 ENSMUST00000137780.2 NM_001371269 uc290lje.1 uc290lje.2 uc290lje.3 molecular_function cellular_component biological_process uc290lje.1 uc290lje.2 uc290lje.3 
ENSMUST00000137802.3 Gm14218 ENSMUST00000137802.3 Gm14218 (from geneSymbol) ENSMUST00000137802.1 ENSMUST00000137802.2 uc290avc.1 uc290avc.2 uc290avc.3 uc290avc.1 uc290avc.2 uc290avc.3 
ENSMUST00000137826.8 Fntb ENSMUST00000137826.8 Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. (from UniProt D3YWJ4) BC031417 D3YWJ4 D3YWJ4_MOUSE ENSMUST00000137826.1 ENSMUST00000137826.2 ENSMUST00000137826.3 ENSMUST00000137826.4 ENSMUST00000137826.5 ENSMUST00000137826.6 ENSMUST00000137826.7 Fntb uc288hhw.1 uc288hhw.2 Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Reaction=(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:13345, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11535, ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:86019, ChEBI:CHEBI:175763; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Heterodimer of FNTA and FNTB. Belongs to the protein prenyltransferase subunit beta family. catalytic activity prenyltransferase activity protein farnesyltransferase activity protein farnesyltransferase complex multicellular organism development zinc ion binding transferase activity protein farnesylation positive regulation of transcription, DNA-templated metal ion binding uc288hhw.1 uc288hhw.2 
ENSMUST00000137882.2 2700068H02Rik ENSMUST00000137882.2 2700068H02Rik (from geneSymbol) AK012503 ENSMUST00000137882.1 uc290ogf.1 uc290ogf.2 uc290ogf.1 uc290ogf.2 
ENSMUST00000137883.4 BC028777 ENSMUST00000137883.4 BC028777 (from geneSymbol) ENSMUST00000137883.1 ENSMUST00000137883.2 ENSMUST00000137883.3 uc289hxv.1 uc289hxv.2 uc289hxv.3 uc289hxv.1 uc289hxv.2 uc289hxv.3 
ENSMUST00000137886.2 Gm14271 ENSMUST00000137886.2 Gm14271 (from geneSymbol) ENSMUST00000137886.1 uc290cxf.1 uc290cxf.2 uc290cxf.1 uc290cxf.2 
ENSMUST00000137907.3 Cep112os1 ENSMUST00000137907.3 centrosomal protein 112, opposite strand 1 (from RefSeq NR_168695.1) ENSMUST00000137907.1 ENSMUST00000137907.2 NR_168695 uc029rpj.1 uc029rpj.2 uc029rpj.3 uc029rpj.1 uc029rpj.2 uc029rpj.3 
ENSMUST00000137958.2 Gm15594 ENSMUST00000137958.2 Gm15594 (from geneSymbol) AK033974 ENSMUST00000137958.1 uc291ctv.1 uc291ctv.2 uc291ctv.1 uc291ctv.2 
ENSMUST00000137962.3 Gm13061 ENSMUST00000137962.3 Gm13061 (from geneSymbol) AK144469 ENSMUST00000137962.1 ENSMUST00000137962.2 uc290qqw.1 uc290qqw.2 uc290qqw.3 uc290qqw.1 uc290qqw.2 uc290qqw.3 
ENSMUST00000137963.8 Mroh4 ENSMUST00000137963.8 Mroh4 (from geneSymbol) 1700016M24Rik BC111897 E9PZ22 E9PZ22_MOUSE ENSMUST00000137963.1 ENSMUST00000137963.2 ENSMUST00000137963.3 ENSMUST00000137963.4 ENSMUST00000137963.5 ENSMUST00000137963.6 ENSMUST00000137963.7 Mroh4 uc011zuc.1 uc011zuc.2 uc011zuc.3 molecular_function Golgi apparatus biological_process uc011zuc.1 uc011zuc.2 uc011zuc.3 
ENSMUST00000138055.2 4930516K23Rik ENSMUST00000138055.2 4930516K23Rik (from geneSymbol) 4930516K23Rik AK015805 ENSMUST00000138055.1 Or51a42 V9GXN4 V9GXN4_MOUSE uc291tso.1 uc291tso.2 olfactory receptor activity G-protein coupled receptor signaling pathway sensory perception of smell integral component of membrane detection of chemical stimulus involved in sensory perception of smell uc291tso.1 uc291tso.2 
ENSMUST00000138077.3 Gm13110 ENSMUST00000138077.3 Gm13110 (from geneSymbol) AK038744 ENSMUST00000138077.1 ENSMUST00000138077.2 uc290sip.1 uc290sip.2 uc290sip.3 uc290sip.1 uc290sip.2 uc290sip.3 
ENSMUST00000138080.2 Gm14280 ENSMUST00000138080.2 Gm14280 (from geneSymbol) AK054143 ENSMUST00000138080.1 uc290aqx.1 uc290aqx.2 uc290aqx.1 uc290aqx.2 
ENSMUST00000138082.3 Gm14718 ENSMUST00000138082.3 predicted gene 14718 (from RefSeq NR_038463.1) ENSMUST00000138082.1 ENSMUST00000138082.2 NR_038463 uc009tha.1 uc009tha.2 uc009tha.3 uc009tha.4 uc009tha.5 uc009tha.6 uc009tha.1 uc009tha.2 uc009tha.3 uc009tha.4 uc009tha.5 uc009tha.6 
ENSMUST00000138087.3 Gm44924 ENSMUST00000138087.3 Gm44924 (from geneSymbol) ENSMUST00000138087.1 ENSMUST00000138087.2 uc291nfq.1 uc291nfq.2 uc291nfq.1 uc291nfq.2 
ENSMUST00000138108.2 Hnf1aos2 ENSMUST00000138108.2 Hnf1aos2 (from geneSymbol) ENSMUST00000138108.1 uc290yrm.1 uc290yrm.2 uc290yrm.1 uc290yrm.2 
ENSMUST00000138109.2 Gm29094 ENSMUST00000138109.2 Belongs to the Bcl-2 family. (from UniProt F6Q785) CT010250 ENSMUST00000138109.1 F6Q785 F6Q785_MOUSE Gm29094 uc292jmw.1 uc292jmw.2 Belongs to the Bcl-2 family. mitochondrial outer membrane intrinsic apoptotic signaling pathway in response to DNA damage protein homodimerization activity regulation of apoptotic process negative regulation of apoptotic process protein heterodimerization activity extrinsic apoptotic signaling pathway in absence of ligand uc292jmw.1 uc292jmw.2 
ENSMUST00000138112.8 Ccdc170 ENSMUST00000138112.8 coiled-coil domain containing 170, transcript variant 3 (from RefSeq NM_001370993.1) Ccdc170 D3YXL0 D3YXL0_MOUSE ENSMUST00000138112.1 ENSMUST00000138112.2 ENSMUST00000138112.3 ENSMUST00000138112.4 ENSMUST00000138112.5 ENSMUST00000138112.6 ENSMUST00000138112.7 Gm221 NM_001370993 uc287phb.1 uc287phb.2 molecular_function cellular_component biological_process uc287phb.1 uc287phb.2 
ENSMUST00000138127.8 Zfp318 ENSMUST00000138127.8 zinc finger protein 318, transcript variant 2 (from RefSeq NM_021346.2) B0V2M3 B9EK88 ENSMUST00000138127.1 ENSMUST00000138127.2 ENSMUST00000138127.3 ENSMUST00000138127.4 ENSMUST00000138127.5 ENSMUST00000138127.6 ENSMUST00000138127.7 NM_021346 Q3TZL5 Q8BMX9 Q99PP2 Q9JJ01 Tzf ZN318_MOUSE Znf318 uc008csr.1 uc008csr.2 uc008csr.3 uc008csr.4 uc008csr.5 [Isoform 2]: Acts as a transcriptional corepressor for AR- mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and in particular, during meiotic division. [Isoform 1]: Acts as a transcriptional coactivator for AR- mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and in particular, during meiotic division. Homodimer. Heterodimer of isoform 1 and isoform 2. Isoform 1 and isoform 2 interact with AR. [Isoform 1]: Nucleus [Isoform 2]: Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=TZF-L; IsoId=Q99PP2-1; Sequence=Displayed; Name=2; IsoId=Q99PP2-2; Sequence=VSP_016594, VSP_016595; Isoform 1 and isoform 2 are highly expressed in testis, moderately expressed in adrenal gland and uterus and faintly expressed in brain, kidney and liver. Isoform 1 is expressed more in adrenal gland, uterus and liver than isoform 2 is. Expression during testicular development of isoform 1 and isoform 2 is restricted to spermatocytes at the pachytene stage of meiotic prophase and to round and elongated spermatids. Sequence=AAF61636.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAF61636.1; Type=Frameshift; Evidence=; Sequence=AAI50731.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI50731.1; Type=Frameshift; Evidence=; Sequence=AAK00650.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAK00650.1; Type=Frameshift; Evidence=; nucleic acid binding protein binding nucleus nucleoplasm cytosol zinc ion binding protein homodimerization activity negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated metal ion binding protein heterodimerization activity meiotic cell cycle uc008csr.1 uc008csr.2 uc008csr.3 uc008csr.4 uc008csr.5 
ENSMUST00000138136.2 Gm12272 ENSMUST00000138136.2 Gm12272 (from geneSymbol) ENSMUST00000138136.1 uc287yud.1 uc287yud.2 uc287yud.1 uc287yud.2 
ENSMUST00000138166.8 Bbx ENSMUST00000138166.8 bobby sox HMG box containing, transcript variant 1 (from RefSeq NM_027444.3) B8JK46 B8JK47 B8JK48 B8JK49 BBX_MOUSE ENSMUST00000138166.1 ENSMUST00000138166.2 ENSMUST00000138166.3 ENSMUST00000138166.4 ENSMUST00000138166.5 ENSMUST00000138166.6 ENSMUST00000138166.7 Hbp2 NM_027444 Q3TZK1 Q6NXY8 Q6PEU3 Q8BQJ7 Q8C7E0 Q8CDQ0 Q8CDV1 Q8VBW5 Q8VI48 Q8VI49 Q8VI50 Q9CS94 uc007zko.1 uc007zko.2 uc007zko.3 uc007zko.4 Transcription factor that is necessary for cell cycle progression from G1 to S phase. Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=BbxA; IsoId=Q8VBW5-1; Sequence=Displayed; Name=2; IsoId=Q8VBW5-2; Sequence=VSP_018007, VSP_018008, VSP_018009; Name=3; IsoId=Q8VBW5-3; Sequence=VSP_018010; Name=4; IsoId=Q8VBW5-4; Sequence=VSP_018011, VSP_018012; Sequence=AAL68987.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAL68988.1; Type=Erroneous initiation; Evidence=; DNA binding nucleus nucleoplasm cytosol bone development uc007zko.1 uc007zko.2 uc007zko.3 uc007zko.4 
ENSMUST00000138180.3 4930583K01Rik ENSMUST00000138180.3 RIKEN cDNA 4930583K01 gene (from RefSeq NR_027879.1) ENSMUST00000138180.1 ENSMUST00000138180.2 NR_027879 uc009jjs.1 uc009jjs.2 uc009jjs.3 uc009jjs.4 uc009jjs.1 uc009jjs.2 uc009jjs.3 uc009jjs.4 
ENSMUST00000138207.2 Gm15964 ENSMUST00000138207.2 Gm15964 (from geneSymbol) AK028982 ENSMUST00000138207.1 uc289gaz.1 uc289gaz.2 uc289gaz.1 uc289gaz.2 
ENSMUST00000138256.3 Gm11773 ENSMUST00000138256.3 Gm11773 (from geneSymbol) ENSMUST00000138256.1 ENSMUST00000138256.2 uc288eke.1 uc288eke.2 uc288eke.3 uc288eke.1 uc288eke.2 uc288eke.3 
ENSMUST00000138259.8 Gm15527 ENSMUST00000138259.8 Gm15527 (from geneSymbol) AK080009 ENSMUST00000138259.1 ENSMUST00000138259.2 ENSMUST00000138259.3 ENSMUST00000138259.4 ENSMUST00000138259.5 ENSMUST00000138259.6 ENSMUST00000138259.7 uc291epm.1 uc291epm.2 uc291epm.1 uc291epm.2 
ENSMUST00000138272.9 Lgals7 ENSMUST00000138272.9 lectin, galactose binding, soluble 7, transcript variant 2 (from RefSeq NM_001403038.1) D3Z141 ENSMUST00000138272.1 ENSMUST00000138272.2 ENSMUST00000138272.3 ENSMUST00000138272.4 ENSMUST00000138272.5 ENSMUST00000138272.6 ENSMUST00000138272.7 ENSMUST00000138272.8 Lgals7 NM_001403038 Q9CRB1 Q9CRB1_MOUSE uc291nmz.1 uc291nmz.2 uc291nmz.3 extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules carbohydrate binding uc291nmz.1 uc291nmz.2 uc291nmz.3 
ENSMUST00000138288.2 Gm14455 ENSMUST00000138288.2 Gm14455 (from geneSymbol) AK047799 ENSMUST00000138288.1 uc290cxo.1 uc290cxo.2 uc290cxo.1 uc290cxo.2 
ENSMUST00000138291.2 Gm12968 ENSMUST00000138291.2 Gm12968 (from geneSymbol) AK036943 ENSMUST00000138291.1 uc290pzy.1 uc290pzy.2 uc290pzy.1 uc290pzy.2 
ENSMUST00000138295.2 Gm11497 ENSMUST00000138295.2 predicted gene 11497 (from RefSeq NR_189017.1) ENSMUST00000138295.1 NR_189017 uc288bia.1 uc288bia.2 uc288bia.1 uc288bia.2 
ENSMUST00000138298.2 Gm14540 ENSMUST00000138298.2 Gm14540 (from geneSymbol) AK133265 ENSMUST00000138298.1 uc291djp.1 uc291djp.2 uc291djp.1 uc291djp.2 
ENSMUST00000138302.9 Wbp1l ENSMUST00000138302.9 WW domain binding protein 1 like, transcript variant 2 (from RefSeq NM_146099.3) D19Wsu162e ENSMUST00000138302.1 ENSMUST00000138302.2 ENSMUST00000138302.3 ENSMUST00000138302.4 ENSMUST00000138302.5 ENSMUST00000138302.6 ENSMUST00000138302.7 ENSMUST00000138302.8 NM_146099 Opal1 Q3TF48 Q3U3M2 Q6PD43 Q8BGW2 Q8R0W8 WBP1L_MOUSE uc008htw.1 uc008htw.2 uc008htw.3 uc008htw.4 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BGW2-1; Sequence=Displayed; Name=2; IsoId=Q8BGW2-2; Sequence=VSP_019442, VSP_041951, VSP_041952; Name=3; IsoId=Q8BGW2-3; Sequence=VSP_019442; Name=4; IsoId=Q8BGW2-4; Sequence=VSP_019443; [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=AAH26369.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH58949.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE41050.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc008htw.1 uc008htw.2 uc008htw.3 uc008htw.4 
ENSMUST00000138303.2 4930545L23Rik ENSMUST00000138303.2 RIKEN cDNA 4930545L23 gene (from RefSeq NR_040517.1) ENSMUST00000138303.1 NR_040517 uc029uew.1 uc029uew.2 uc029uew.1 uc029uew.2 
ENSMUST00000138341.2 Gm14547 ENSMUST00000138341.2 Gm14547 (from geneSymbol) ENSMUST00000138341.1 uc291dlo.1 uc291dlo.2 uc291dlo.1 uc291dlo.2 
ENSMUST00000138361.3 Gm13648 ENSMUST00000138361.3 predicted gene 13648 (from RefSeq NR_132444.1) ENSMUST00000138361.1 ENSMUST00000138361.2 NR_132444 uc057bta.1 uc057bta.2 uc057bta.3 uc057bta.4 uc057bta.1 uc057bta.2 uc057bta.3 uc057bta.4 
ENSMUST00000138372.2 Gm13982 ENSMUST00000138372.2 Gm13982 (from geneSymbol) AK040062 ENSMUST00000138372.1 uc008lrn.1 uc008lrn.2 uc008lrn.1 uc008lrn.2 
ENSMUST00000138374.2 Gm12498 ENSMUST00000138374.2 Gm12498 (from geneSymbol) AK079211 ENSMUST00000138374.1 uc290iqu.1 uc290iqu.2 uc290iqu.1 uc290iqu.2 
ENSMUST00000138390.8 4930412C18Rik ENSMUST00000138390.8 4930412C18Rik (from geneSymbol) AK076677 ENSMUST00000138390.1 ENSMUST00000138390.2 ENSMUST00000138390.3 ENSMUST00000138390.4 ENSMUST00000138390.5 ENSMUST00000138390.6 ENSMUST00000138390.7 uc008rys.1 uc008rys.2 uc008rys.3 uc008rys.1 uc008rys.2 uc008rys.3 
ENSMUST00000138402.3 Gm12089 ENSMUST00000138402.3 Gm12089 (from geneSymbol) ENSMUST00000138402.1 ENSMUST00000138402.2 KY467575 uc057kkq.1 uc057kkq.2 uc057kkq.3 uc057kkq.1 uc057kkq.2 uc057kkq.3 
ENSMUST00000138403.2 Lce6a ENSMUST00000138403.2 late cornified envelope 6A, transcript variant 1 (from RefSeq NM_001166172.2) D3YV94 D3YV94_MOUSE ENSMUST00000138403.1 Lce6a NM_001166172 uc008qeh.1 uc008qeh.2 uc008qeh.3 uc008qeh.4 molecular_function cellular_component biological_process uc008qeh.1 uc008qeh.2 uc008qeh.3 uc008qeh.4 
ENSMUST00000138406.2 Gm15721 ENSMUST00000138406.2 Gm15721 (from geneSymbol) AK139178 ENSMUST00000138406.1 uc291bxb.1 uc291bxb.2 uc291bxb.1 uc291bxb.2 
ENSMUST00000138416.3 Gm13264 ENSMUST00000138416.3 Gm13264 (from geneSymbol) AK140051 ENSMUST00000138416.1 ENSMUST00000138416.2 uc289szm.1 uc289szm.2 uc289szm.1 uc289szm.2 
ENSMUST00000138426.2 Gm12953 ENSMUST00000138426.2 Gm12953 (from geneSymbol) ENSMUST00000138426.1 uc290oys.1 uc290oys.2 uc290oys.1 uc290oys.2 
ENSMUST00000138427.2 Gm14205 ENSMUST00000138427.2 Gm14205 (from geneSymbol) ENSMUST00000138427.1 uc290cec.1 uc290cec.2 uc290cec.1 uc290cec.2 
ENSMUST00000138439.2 Cd209f ENSMUST00000138439.2 Cd209f (from geneSymbol) AK007638 Cd209f D3Z1H5 D3Z1H5_MOUSE ENSMUST00000138439.1 uc009ksx.1 uc009ksx.2 uc009ksx.3 uc009ksx.4 mannose binding cellular_component biological_process membrane integral component of membrane carbohydrate binding uc009ksx.1 uc009ksx.2 uc009ksx.3 uc009ksx.4 
ENSMUST00000138442.2 2810455O05Rik ENSMUST00000138442.2 2810455O05Rik (from geneSymbol) AK013357 ENSMUST00000138442.1 uc292dzp.1 uc292dzp.2 uc292dzp.1 uc292dzp.2 
ENSMUST00000138462.3 Gm13189 ENSMUST00000138462.3 Gm13189 (from geneSymbol) ENSMUST00000138462.1 ENSMUST00000138462.2 uc289srl.1 uc289srl.2 uc289srl.3 uc289srl.1 uc289srl.2 uc289srl.3 
ENSMUST00000138467.2 Gm15092 ENSMUST00000138467.2 Gm15092 (from geneSymbol) ENSMUST00000138467.1 uc292rba.1 uc292rba.2 uc292rba.1 uc292rba.2 
ENSMUST00000138492.2 Gm13209 ENSMUST00000138492.2 Gm13209 (from geneSymbol) ENSMUST00000138492.1 uc290rvi.1 uc290rvi.2 uc290rvi.1 uc290rvi.2 
ENSMUST00000138502.2 Rps20 ENSMUST00000138502.2 ribosomal protein S20 (from RefSeq NM_026147.7) ENSMUST00000138502.1 NM_026147 Q5BLK2 Q5BLK2_MOUSE Rps20 uc008rwn.1 uc008rwn.2 uc008rwn.3 uc008rwn.4 Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.69771.1, BY714044.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Component of the 40S small ribosomal subunit. Belongs to the universal ribosomal protein uS10 family. RNA binding structural constituent of ribosome ribosome translation small ribosomal subunit uc008rwn.1 uc008rwn.2 uc008rwn.3 uc008rwn.4 
ENSMUST00000138532.8 Syvn1 ENSMUST00000138532.8 synovial apoptosis inhibitor 1, synoviolin, transcript variant 1 (from RefSeq NM_028769.5) A0A0R4J1R1 A0A0R4J1R1_MOUSE ENSMUST00000138532.1 ENSMUST00000138532.2 ENSMUST00000138532.3 ENSMUST00000138532.4 ENSMUST00000138532.5 ENSMUST00000138532.6 ENSMUST00000138532.7 NM_028769 Syvn1 uc008ggm.1 uc008ggm.2 uc008ggm.3 uc008ggm.4 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the HRD1 family. Hrd1p ubiquitin ligase complex Hrd1p ubiquitin ligase ERAD-L complex nucleoplasm endoplasmic reticulum smooth endoplasmic reticulum ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination protein N-linked glycosylation via asparagine ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol ERAD pathway Derlin-1 retrotranslocation complex protein stabilization unfolded protein binding chaperone binding ATPase binding ubiquitin protein ligase activity protein K48-linked ubiquitination negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ubiquitin-specific protease binding uc008ggm.1 uc008ggm.2 uc008ggm.3 uc008ggm.4 
ENSMUST00000138535.8 Pard3bos1 ENSMUST00000138535.8 Pard3bos1 (from geneSymbol) AK015421 ENSMUST00000138535.1 ENSMUST00000138535.2 ENSMUST00000138535.3 ENSMUST00000138535.4 ENSMUST00000138535.5 ENSMUST00000138535.6 ENSMUST00000138535.7 uc007bfg.1 uc007bfg.2 uc007bfg.3 uc007bfg.1 uc007bfg.2 uc007bfg.3 
ENSMUST00000138539.2 Gm15591 ENSMUST00000138539.2 Gm15591 (from geneSymbol) ENSMUST00000138539.1 uc289ewo.1 uc289ewo.2 uc289ewo.1 uc289ewo.2 
ENSMUST00000138574.3 Gm11381 ENSMUST00000138574.3 predicted gene 11381, transcript variant 2 (from RefSeq NR_188885.1) ENSMUST00000138574.1 ENSMUST00000138574.2 NR_188885 uc288lub.1 uc288lub.2 uc288lub.3 uc288lub.1 uc288lub.2 uc288lub.3 
ENSMUST00000138595.3 Crocc2 ENSMUST00000138595.3 ciliary rootlet coiled-coil, rootletin family member 2 (from RefSeq NM_001310428.1) CRCC2_MOUSE Crocc2 ENSMUST00000138595.1 ENSMUST00000138595.2 F6XLV1 NM_001310428 uc057ava.1 uc057ava.2 uc057ava.3 uc057ava.4 Belongs to the rootletin family. molecular_function cellular_component biological_process uc057ava.1 uc057ava.2 uc057ava.3 uc057ava.4 
ENSMUST00000138617.2 Atxn7l1os2 ENSMUST00000138617.2 ataxin 7-like 1, opposite strand 2 (from RefSeq NR_131031.1) ENSMUST00000138617.1 NR_131031 uc056yqa.1 uc056yqa.2 uc056yqa.3 uc056yqa.1 uc056yqa.2 uc056yqa.3 
ENSMUST00000138626.2 Gm15691 ENSMUST00000138626.2 Gm15691 (from geneSymbol) ENSMUST00000138626.1 uc288frv.1 uc288frv.2 uc288frv.1 uc288frv.2 
ENSMUST00000138642.3 Ssxb6 ENSMUST00000138642.3 SSX member B6 (from RefSeq NM_001205108.1) A2BI74 A2BI74_MOUSE ENSMUST00000138642.1 ENSMUST00000138642.2 NM_001205108 Ssxb6 uc029xhz.1 uc029xhz.2 uc029xhz.3 Belongs to the SSX family. nucleic acid binding nucleus regulation of transcription, DNA-templated uc029xhz.1 uc029xhz.2 uc029xhz.3 
ENSMUST00000138667.2 Gm20716 ENSMUST00000138667.2 predicted gene 20716 (from RefSeq NR_132310.1) DPM1_MOUSE Dpm1 ENSMUST00000138667.1 NR_132310 O70152 Q9D829 uc290cuf.1 uc290cuf.2 This locus represents naturally occurring readthrough transcription between the neighboring Dpm1 (dolichol-phosphate (beta-D) mannosyltransferase 1) and Adnp (activity-dependent neuroprotective protein) genes on chromosome 2. The readthrough transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Jun 2015]. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 11538, 13480 ##RefSeq-Attributes-END## Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. Reaction=a dolichyl phosphate + GDP-alpha-D-mannose = a dolichyl beta- D-mannosyl phosphate + GDP; Xref=Rhea:RHEA:21184, Rhea:RHEA- COMP:9517, Rhea:RHEA-COMP:9527, ChEBI:CHEBI:57527, ChEBI:CHEBI:57683, ChEBI:CHEBI:58189, ChEBI:CHEBI:58211; EC=2.4.1.83; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 divalent metal cation. ; Protein modification; protein glycosylation. Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; within the complex, directly interacts with DPM3. This interaction may stabilize DPM1. Endoplasmic reticulum. Belongs to the glycosyltransferase 2 family. dolichyl-phosphate-mannose-protein mannosyltransferase activity dolichyl-phosphate beta-D-mannosyltransferase activity mannose binding endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation GPI anchor biosynthetic process membrane transferase activity transferase activity, transferring glycosyl groups dolichol metabolic process GDP-mannose metabolic process dolichol-phosphate-mannose synthase complex protein mannosylation protein O-linked mannosylation alcohol binding intracellular membrane-bounded organelle uc290cuf.1 uc290cuf.2 
ENSMUST00000138670.3 Gm15083 ENSMUST00000138670.3 predicted gene 15083, transcript variant 2 (from RefSeq NR_167896.1) ENSMUST00000138670.1 ENSMUST00000138670.2 NR_167896 uc291hwz.1 uc291hwz.2 uc291hwz.1 uc291hwz.2 
ENSMUST00000138675.3 4930483J18Rik ENSMUST00000138675.3 4930483J18Rik (from geneSymbol) BC049560 ENSMUST00000138675.1 ENSMUST00000138675.2 uc288zwo.1 uc288zwo.2 uc288zwo.3 uc288zwo.1 uc288zwo.2 uc288zwo.3 
ENSMUST00000138702.2 Gm11722 ENSMUST00000138702.2 Gm11722 (from geneSymbol) ENSMUST00000138702.1 KY467614 uc288dco.1 uc288dco.2 uc288dco.1 uc288dco.2 
ENSMUST00000138703.8 Pfkp ENSMUST00000138703.8 phosphofructokinase, platelet, transcript variant 1 (from RefSeq NM_019703.4) ENSMUST00000138703.1 ENSMUST00000138703.2 ENSMUST00000138703.3 ENSMUST00000138703.4 ENSMUST00000138703.5 ENSMUST00000138703.6 ENSMUST00000138703.7 NM_019703 PFKAP_MOUSE Pfkc Q3TNA9 Q3U4P1 Q3U7G4 Q4KUG1 Q543K8 Q8C5I6 Q9JI86 Q9WUA3 uc007pjz.1 uc007pjz.2 uc007pjz.3 uc007pjz.4 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6- bisphosphate + H(+); Xref=Rhea:RHEA:16109, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:32966, ChEBI:CHEBI:57634, ChEBI:CHEBI:456216; EC=2.7.1.11; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 3/4. Homo- and heterotetramers (By similarity). Phosphofructokinase (PFK) enzyme functions as a tetramer composed of different combinations of 3 types of subunits, called PFKM (M), PFKL (L) and PFKP (P). The composition of the PFK tetramer differs according to the tissue type it is present in. The kinetic and regulatory properties of the tetrameric enzyme are dependent on the subunit composition, hence can vary across tissues (Probable). Interacts with ATG4B; promoting phosphorylation of ATG4B. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WUA3-1; Sequence=Displayed; Name=2; IsoId=Q9WUA3-2; Sequence=VSP_016664, VSP_016665; Expression is constant during tumor growth and markedly decreases when cell proliferation stops. GlcNAcylation decreases enzyme activity. [Isoform 2]: May be due to intron retention. Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. nucleotide binding catalytic activity 6-phosphofructokinase activity ATP binding cytoplasm cytosol 6-phosphofructokinase complex fructose 6-phosphate metabolic process glucose catabolic process glycolytic process metabolic process membrane AMP binding kinase activity phosphorylation transferase activity fructose 1,6-bisphosphate metabolic process identical protein binding macromolecular complex binding metal ion binding monosaccharide binding protein homotetramerization glycolytic process through fructose-6-phosphate canonical glycolysis fructose-6-phosphate binding cellular response to leukemia inhibitory factor uc007pjz.1 uc007pjz.2 uc007pjz.3 uc007pjz.4 
ENSMUST00000138710.3 Gm43439 ENSMUST00000138710.3 Gm43439 (from geneSymbol) AY027548 ENSMUST00000138710.1 ENSMUST00000138710.2 uc290esj.1 uc290esj.2 uc290esj.1 uc290esj.2 
ENSMUST00000138744.2 Gm16725 ENSMUST00000138744.2 predicted gene, 16725 (from RefSeq NR_188750.1) ENSMUST00000138744.1 NR_188750 uc291ynq.1 uc291ynq.2 uc291ynq.1 uc291ynq.2 
ENSMUST00000138762.8 Cep350 ENSMUST00000138762.8 centrosomal protein 350 (from RefSeq NM_001039184.2) A0A1D5RMJ4 CE350_MOUSE Cep350 D3YTP2 E9Q309 ENSMUST00000138762.1 ENSMUST00000138762.2 ENSMUST00000138762.3 ENSMUST00000138762.4 ENSMUST00000138762.5 ENSMUST00000138762.6 ENSMUST00000138762.7 Kiaa0480 NM_001039184 Q6A062 Q8BXM7 uc007dbs.1 uc007dbs.2 uc007dbs.3 Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. Part of a ternary complex that contains CEP350, CEP43 and MAPRE1. Interacts (via C-terminus) directly with CEP43 (via N- terminus). Interacts with NR1H3, PPARA, PPARD and PPARG. Interacts directly with microtubules. Interacts with the fusion protein CEP43- FGFR1, and by doing so recruits and activates PI3K and PLC-gamma. Interacts with CYLD (By similarity). Interacts with CFAP157 (PubMed:27965440). Interacts with CEP19 (via C-terminus) (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body Note=Associated with mitotic spindles. Nuclear, in discrete foci. Associated with intermediate filaments. Also present in the pericentrosomal area. Localizes on both mother and daughter centrioles. Localizes to an axial position on the mother centriole. Localizes to the distal end of the centriole on the subdistal appendage region. Phosphorylated during mitosis. protein binding nucleus cytoplasm centrosome centriole microtubule organizing center spindle cytoskeleton microtubule binding biological_process microtubule anchoring cell projection uc007dbs.1 uc007dbs.2 uc007dbs.3 
ENSMUST00000138763.9 4933439C10Rik ENSMUST00000138763.9 4933439C10Rik (from geneSymbol) AK030920 ENSMUST00000138763.1 ENSMUST00000138763.2 ENSMUST00000138763.3 ENSMUST00000138763.4 ENSMUST00000138763.5 ENSMUST00000138763.6 ENSMUST00000138763.7 ENSMUST00000138763.8 uc287ynb.1 uc287ynb.2 uc287ynb.3 uc287ynb.1 uc287ynb.2 uc287ynb.3 
ENSMUST00000138767.2 9530036M11Rik ENSMUST00000138767.2 9530036M11Rik (from geneSymbol) AK137178 ENSMUST00000138767.1 uc009bzp.1 uc009bzp.2 uc009bzp.3 uc009bzp.1 uc009bzp.2 uc009bzp.3 
ENSMUST00000138785.8 Dnmt3l ENSMUST00000138785.8 DNA methyltransferase 3-like, transcript variant 2 (from RefSeq NM_001081695.2) DNM3L_MOUSE ENSMUST00000138785.1 ENSMUST00000138785.2 ENSMUST00000138785.3 ENSMUST00000138785.4 ENSMUST00000138785.5 ENSMUST00000138785.6 ENSMUST00000138785.7 NM_001081695 Q9CWR8 uc007fxe.1 uc007fxe.2 uc007fxe.3 CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein that is a catalytically inactive regulatory factor of DNA methyltransferases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (PubMed:11719692, PubMed:15318244, PubMed:15671018, PubMed:24074865). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:15671018). Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:15671018). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (By similarity). Plays a key role in embryonic stem cells and germ cells (PubMed:11719692, PubMed:15318244, PubMed:24074865). In germ cells, required for the methylation of imprinted loci together with DNMT3A (PubMed:11719692). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (PubMed:15318244). Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (PubMed:24074865). While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (PubMed:24074865). Interacts with the EZH2 component of the PRC2/EED- EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (PubMed:24074865). Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (PubMed:24074865). Homodimer (By similarity). Heterotetramer composed of 1 DNMT3A homodimer and 2 DNMT3L subunits (DNMT3L-DNMT3A-DNMT3A-DNMT3L) (By similarity). Interacts with histone H3 (via N-terminus); interaction is strongly inhibited by methylation at lysine 4 (H3K4me) (By similarity). Interacts with EZH2; the interaction is direct (PubMed:24074865). Interacts with SPOCD1 (PubMed:32674113). Q9CWR8; O88508: Dnmt3a; NbExp=6; IntAct=EBI-3043871, EBI-995154; Q9CWR8; O88508-1: Dnmt3a; NbExp=6; IntAct=EBI-3043871, EBI-15650457; Q9CWR8; O88509: Dnmt3b; NbExp=6; IntAct=EBI-3043871, EBI-7987547; Q9CWR8; Q61188: Ezh2; NbExp=10; IntAct=EBI-3043871, EBI-904311; Q9CWR8; Q15910: EZH2; Xeno; NbExp=2; IntAct=EBI-3043871, EBI-530054; Nucleus Expressed in testis, thymus, ovary, and heart (PubMed:11306809). In testis, first observed in non-dividing prospermatogonia after 12.5 dpc and is highest at about the time of birth; expression declines rapidly after birth and is extinguished by 6 days post partum, when most prospermatogonia have differentiated into dividing spermatogonial stem cells (PubMed:15318244). Oogenesis in female mice takes place normally, but the heterozygous offspring of homozygous mutant females die before mid-gestation due to biallelic expression of imprinted genes normally methylated and silenced on the allele of maternal origin (PubMed:11719692). Male mice are viable but sterile, with a complete absence of germ cells in adult males (PubMed:11719692). Spermatocytes show asynapsis or abnormal synapsis, and do not progress to the full pachytene stage due to demethylation of methylation of both long- terminal-repeat (LTR) and non-LTR retrotransposons (PubMed:15318244). condensed nuclear chromosome in utero embryonic development placenta development protein binding nucleus nucleoplasm nuclear heterochromatin cytoplasm DNA methylation male meiosis I spermatogenesis enzyme activator activity negative regulation of transposition enzyme binding cell differentiation enzyme regulator activity methylation DNA methylation on cytosine DNA methylation involved in gamete generation positive regulation of catalytic activity negative regulation of transcription, DNA-templated metal ion binding stem cell differentiation regulation of catalytic activity chorionic trophoblast cell differentiation genetic imprinting negative regulation of DNA methylation positive regulation of DNA methylation ESC/E(Z) complex uc007fxe.1 uc007fxe.2 uc007fxe.3 
ENSMUST00000138817.2 Gm12343 ENSMUST00000138817.2 Gm12343 (from geneSymbol) ENSMUST00000138817.1 uc288aiw.1 uc288aiw.2 uc288aiw.1 uc288aiw.2 
ENSMUST00000138819.2 Gm12299 ENSMUST00000138819.2 Gm12299 (from geneSymbol) AK030260 ENSMUST00000138819.1 uc287zaj.1 uc287zaj.2 uc287zaj.1 uc287zaj.2 
ENSMUST00000138832.2 Gm15384 ENSMUST00000138832.2 Gm15384 (from geneSymbol) ENSMUST00000138832.1 uc292pdb.1 uc292pdb.2 uc292pdb.1 uc292pdb.2 
ENSMUST00000138844.4 Efhd1os ENSMUST00000138844.4 Efhd1os (from geneSymbol) ENSMUST00000138844.1 ENSMUST00000138844.2 ENSMUST00000138844.3 uc287kcj.1 uc287kcj.2 uc287kcj.3 uc287kcj.1 uc287kcj.2 uc287kcj.3 
ENSMUST00000138880.9 Nol12 ENSMUST00000138880.9 nucleolar protein 12, transcript variant 1 (from RefSeq NM_133800.4) ENSMUST00000138880.1 ENSMUST00000138880.2 ENSMUST00000138880.3 ENSMUST00000138880.4 ENSMUST00000138880.5 ENSMUST00000138880.6 ENSMUST00000138880.7 ENSMUST00000138880.8 NM_133800 NOL12_MOUSE Nop25 Q8BG17 Q91VI1 uc007wrw.1 uc007wrw.2 uc007wrw.3 May bind to 28S rRNA. In vitro binds single-stranded nucleic acids. Interacts with KIAA1191. Nucleus, nucleolus Expressed in brain, lung, spleen, kidney and heart. Continuously expressed during embryogenesis. Belongs to the RRP17 family. single-stranded DNA binding RNA binding nucleus nucleolus rRNA binding uc007wrw.1 uc007wrw.2 uc007wrw.3 
ENSMUST00000138883.2 Gm13799 ENSMUST00000138883.2 Gm13799 (from geneSymbol) AK029614 ENSMUST00000138883.1 uc008lhb.1 uc008lhb.2 uc008lhb.1 uc008lhb.2 
ENSMUST00000138891.8 Gm16764 ENSMUST00000138891.8 Gm16764 (from geneSymbol) ENSMUST00000138891.1 ENSMUST00000138891.2 ENSMUST00000138891.3 ENSMUST00000138891.4 ENSMUST00000138891.5 ENSMUST00000138891.6 ENSMUST00000138891.7 uc291wjn.1 uc291wjn.2 uc291wjn.1 uc291wjn.2 
ENSMUST00000138926.2 Gm15929 ENSMUST00000138926.2 Gm15929 (from geneSymbol) AK132602 ENSMUST00000138926.1 uc291kpk.1 uc291kpk.2 uc291kpk.1 uc291kpk.2 
ENSMUST00000138943.8 4933407K13Rik ENSMUST00000138943.8 4933407K13Rik (from geneSymbol) AK163097 ENSMUST00000138943.1 ENSMUST00000138943.2 ENSMUST00000138943.3 ENSMUST00000138943.4 ENSMUST00000138943.5 ENSMUST00000138943.6 ENSMUST00000138943.7 uc292pde.1 uc292pde.2 uc292pde.1 uc292pde.2 
ENSMUST00000138966.9 Skint6 ENSMUST00000138966.9 selection and upkeep of intraepithelial T cells 6 (from RefSeq NM_001103199.1) A7XUZ6 A7XV01 ENSMUST00000138966.1 ENSMUST00000138966.2 ENSMUST00000138966.3 ENSMUST00000138966.4 ENSMUST00000138966.5 ENSMUST00000138966.6 ENSMUST00000138966.7 ENSMUST00000138966.8 NM_001103199 SKIT6_MOUSE uc009vcx.1 uc009vcx.2 May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A; IsoId=A7XUZ6-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=A7XUZ6-2; Sequence=VSP_034886, VSP_034887; Expressed in skin. Encoded by one of the 11 copies of Skint genes clustered in the D1 region of the chromosome 4. Belongs to the SKINT family. receptor binding external side of plasma membrane membrane integral component of membrane regulation of immune response T cell receptor signaling pathway uc009vcx.1 uc009vcx.2 
ENSMUST00000138988.2 Gm15123 ENSMUST00000138988.2 Gm15123 (from geneSymbol) ENSMUST00000138988.1 uc287szw.1 uc287szw.2 uc287szw.1 uc287szw.2 
ENSMUST00000138992.2 Gm15911 ENSMUST00000138992.2 Gm15911 (from geneSymbol) ENSMUST00000138992.1 uc288ndc.1 uc288ndc.2 uc288ndc.1 uc288ndc.2 
ENSMUST00000139012.2 Gm12916 ENSMUST00000139012.2 Gm12916 (from geneSymbol) AK079012 ENSMUST00000139012.1 uc008uqo.1 uc008uqo.2 uc008uqo.1 uc008uqo.2 
ENSMUST00000139025.4 Gm12265 ENSMUST00000139025.4 Gm12265 (from geneSymbol) ENSMUST00000139025.1 ENSMUST00000139025.2 ENSMUST00000139025.3 uc287ypo.1 uc287ypo.2 uc287ypo.3 uc287ypo.4 uc287ypo.1 uc287ypo.2 uc287ypo.3 uc287ypo.4 
ENSMUST00000139049.2 Prps1l3 ENSMUST00000139049.2 phosphoribosyl pyrophosphate synthetase 1-like 3 (from RefSeq NM_001037746.3) ENSMUST00000139049.1 G3UXL2 G3UXL2_MOUSE NM_001037746 Prps1l3 uc033gdp.1 uc033gdp.2 uc033gdp.3 Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. Homodimer. The active form is probably a hexamer composed of 3 homodimers. Belongs to the ribose-phosphate pyrophosphokinase family. magnesium ion binding ribose phosphate diphosphokinase complex ribose phosphate diphosphokinase activity ATP binding cytoplasm 5-phosphoribose 1-diphosphate biosynthetic process purine nucleotide biosynthetic process nucleoside metabolic process ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process cellular biosynthetic process uc033gdp.1 uc033gdp.2 uc033gdp.3 
ENSMUST00000139058.2 Gm14040 ENSMUST00000139058.2 predicted gene 14040 (from RefSeq NR_166423.1) ENSMUST00000139058.1 NR_166423 uc008mhy.1 uc008mhy.2 uc008mhy.3 uc008mhy.1 uc008mhy.2 uc008mhy.3 
ENSMUST00000139064.11 Pou6f2 ENSMUST00000139064.11 POU domain, class 6, transcription factor 2 (from RefSeq NM_175006.3) ENSMUST00000139064.1 ENSMUST00000139064.10 ENSMUST00000139064.2 ENSMUST00000139064.3 ENSMUST00000139064.4 ENSMUST00000139064.5 ENSMUST00000139064.6 ENSMUST00000139064.7 ENSMUST00000139064.8 ENSMUST00000139064.9 F6ZW42 F6ZW42_MOUSE NM_175006 Pou6f2 uc288lar.1 uc288lar.2 uc288lar.3 Nucleus Belongs to the POU transcription factor family. DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development uc288lar.1 uc288lar.2 uc288lar.3 
ENSMUST00000139065.2 A930006I01Rik ENSMUST00000139065.2 RIKEN cDNA A930006I01 gene (from RefSeq NR_040332.1) ENSMUST00000139065.1 NR_040332 uc008lir.1 uc008lir.2 uc008lir.3 uc008lir.1 uc008lir.2 uc008lir.3 
ENSMUST00000139075.8 Slmap ENSMUST00000139075.8 sarcolemma associated protein, transcript variant 1 (from RefSeq NM_001310445.1) ENSMUST00000139075.1 ENSMUST00000139075.2 ENSMUST00000139075.3 ENSMUST00000139075.4 ENSMUST00000139075.5 ENSMUST00000139075.6 ENSMUST00000139075.7 Kiaa1601 NM_001310445 Q3TLP0 Q3UIZ6 Q3URD3 Q6ZPL8 Q8VC86 Q9EQ03 SLMAP_MOUSE Slap uc007sss.1 uc007sss.2 uc007sss.3 uc007sss.4 May play a role during myoblast fusion. Homodimer. Interacts with myosin. Q3URD3-4; Q8BH43: Wasf2; NbExp=3; IntAct=EBI-3294998, EBI-643162; Cell membrane, sarcolemma ; Single- pass type IV membrane protein Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum (By similarity). Detected along the Z- and M-lines in cardiomyocytes (By similarity). [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosomes in a microtubule- dependent manner. [Isoform 2]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosomes in a microtubule- dependent manner. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q3URD3-1; Sequence=Displayed; Name=2; IsoId=Q3URD3-2; Sequence=VSP_021517, VSP_021518; Name=3; IsoId=Q3URD3-3; Sequence=VSP_021514; Name=4; IsoId=Q3URD3-4; Sequence=VSP_021514, VSP_021518; Name=5; IsoId=Q3URD3-5; Sequence=VSP_021515, VSP_021516; Expressed in proliferating myoblasts and differentiated myotubes (at protein level). Expressed in myoblasts, cardiac and skeletal muscles. Expressed in atrial and ventricular chambers of the primitive heart at 9 dpc. Expressed in somites at 11 dpc. Expressed in atrial and ventricular chambers and interventricular and interatrial septum at 13 dpc. Expressed in myotubes between 13 and 15 dpc. Expressed in skeletal muscles at 18 dpc. Belongs to the SLMAP family. Sequence=BAC98213.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE24755.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding extracellular space cytoplasm microtubule organizing center cytoskeleton plasma membrane muscle contraction membrane integral component of membrane Z disc M band sarcolemma protein localization to plasma membrane regulation of membrane depolarization during cardiac muscle cell action potential regulation of sodium ion transmembrane transport regulation of voltage-gated sodium channel activity uc007sss.1 uc007sss.2 uc007sss.3 uc007sss.4 
ENSMUST00000139089.2 Sspnos ENSMUST00000139089.2 Sspnos (from geneSymbol) AK084599 ENSMUST00000139089.1 uc009erv.1 uc009erv.2 uc009erv.1 uc009erv.2 
ENSMUST00000139092.8 Ifi214 ENSMUST00000139092.8 interferon activated gene 214 (from RefSeq NM_001024721.2) A0A0R4J1R5 A0A0R4J1R5_MOUSE BC094916 ENSMUST00000139092.1 ENSMUST00000139092.2 ENSMUST00000139092.3 ENSMUST00000139092.4 ENSMUST00000139092.5 ENSMUST00000139092.6 ENSMUST00000139092.7 Ifi214 NM_001024721 uc007dro.1 uc007dro.2 uc007dro.3 uc007dro.4 This gene encodes a protein that is a member of the PAAD/DAPIN/Pyrin domain family of proteins. However, compared to the related pyrin and HIN domain family, member 1 (Pyhin1) protein, this protein is C-terminally truncated and lacks a HIN domain, which has an unknown function. It is therefore possible that this gene represents a pseudogene of the Pyhin1 gene, but it is currently being retained as a functional protein-coding gene based on the presence of an intact PAAD/DAPIN/Pyrin domain. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK156095.1, AK171847.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Belongs to the HIN-200 family. activation of innate immune response cellular response to interferon-beta uc007dro.1 uc007dro.2 uc007dro.3 uc007dro.4 
ENSMUST00000139095.2 A830036E02Rik ENSMUST00000139095.2 RIKEN cDNA A830036E02 gene (from RefSeq NR_153851.1) ENSMUST00000139095.1 NR_153851 uc007lit.1 uc007lit.2 uc007lit.1 uc007lit.2 
ENSMUST00000139112.8 Gm14974 ENSMUST00000139112.8 Gm14974 (from geneSymbol) AK135675 ENSMUST00000139112.1 ENSMUST00000139112.2 ENSMUST00000139112.3 ENSMUST00000139112.4 ENSMUST00000139112.5 ENSMUST00000139112.6 ENSMUST00000139112.7 uc292npt.1 uc292npt.2 uc292npt.1 uc292npt.2 
ENSMUST00000139119.4 Gm12454 ENSMUST00000139119.4 Gm12454 (from geneSymbol) ENSMUST00000139119.1 ENSMUST00000139119.2 ENSMUST00000139119.3 uc290mfl.1 uc290mfl.2 uc290mfl.3 uc290mfl.4 uc290mfl.1 uc290mfl.2 uc290mfl.3 uc290mfl.4 
ENSMUST00000139122.8 Smim14 ENSMUST00000139122.8 small integral membrane protein 14, transcript variant 1 (from RefSeq NM_133697.4) ENSMUST00000139122.1 ENSMUST00000139122.2 ENSMUST00000139122.3 ENSMUST00000139122.4 ENSMUST00000139122.5 ENSMUST00000139122.6 ENSMUST00000139122.7 NM_133697 Q91VT8 SIM14_MOUSE uc008xnt.1 uc008xnt.2 uc008xnt.3 Endoplasmic reticulum membrane ; Single-pass membrane protein Ubiquitously expressed. blastocyst hatching molecular_function endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane uc008xnt.1 uc008xnt.2 uc008xnt.3 
ENSMUST00000139129.9 Srsf1 ENSMUST00000139129.9 serine and arginine-rich splicing factor 1, transcript variant 1 (from RefSeq NM_173374.4) B2KGJ5 ENSMUST00000139129.1 ENSMUST00000139129.2 ENSMUST00000139129.3 ENSMUST00000139129.4 ENSMUST00000139129.5 ENSMUST00000139129.6 ENSMUST00000139129.7 ENSMUST00000139129.8 NM_173374 Q3UCH2 Q5SXC5 Q6PDM2 Q8BJV3 Q8C1H9 SRSF1_MOUSE Sfrs1 Srsf1 uc007kvc.1 uc007kvc.2 uc007kvc.3 uc007kvc.4 The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]. Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing (PubMed:28785060). Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'- CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing (By similarity). Specifically regulates alternative splicing of cardiac isoforms of CAMK2D, LDB3/CYPHER and TNNT2/CTNT during heart remodeling at the juvenile to adult transition. The inappropriate accumulation of a neonatal and neuronal isoform of CAMKD2 in the adult heart results in aberrant calcium handling and defective excitation-contraction coupling in cardiomyocytes. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway (PubMed:15652482). Consists of two polypeptides of p32 and p33. Identified in the spliceosome C complex. Component of a ribonucleoprotein complex containing mRNAs and RNA-binding proteins including DDX5, HNRNPH2 and SRSF1 as well as splicing regulator ARVCF (By similarity). In vitro, self-associates and binds SRSF2, SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with SAFB/SAFB1. Interacts with PSIP1/LEDGF. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus). Interacts with SRPK1 and a sliding docking interaction is essential for its sequential and processive phosphorylation by SRPK1. Interacts with NXF1. Interacts with CCNL1, CCNL2 and CDK11B. Interacts with RRP1B. Interacts (when phosphorylated in its RS domain) with TNPO3; promoting nuclear import. Interacts with ILDR1 (via C-terminus) and ILDR2 (PubMed:28785060). Q6PDM2; Q8R409: Hexim1; NbExp=4; IntAct=EBI-2550360, EBI-6261031; Q6PDM2; P08775: Polr2a; NbExp=2; IntAct=EBI-2550360, EBI-2549849; Q6PDM2; P70318: Tial1; NbExp=3; IntAct=EBI-2550360, EBI-299820; Q6PDM2; P70191: Traf5; NbExp=2; IntAct=EBI-2550360, EBI-523899; Cytoplasm Nucleus speckle Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm. Nuclear import is mediated via interaction with TNPO3. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PDM2-1; Sequence=Displayed; Name=2; IsoId=Q6PDM2-2; Sequence=VSP_013770, VSP_013773; Name=3; IsoId=Q6PDM2-3; Sequence=VSP_013771, VSP_013772; Expressed in inner ear. The RRM 2 domain plays an important role in governing both the binding mode and the phosphorylation mechanism of the RS domain by SRPK1. RS domain and RRM 2 are uniquely positioned to initiate a highly directional (C-terminus to N-terminus) phosphorylation reaction in which the RS domain slides through an extended electronegative channel separating the docking groove of SRPK1 and the active site. RRM 2 binds toward the periphery of the active site and guides the directional phosphorylation mechanism. Both the RS domain and an RRM domain are required for nucleocytoplasmic shuttling (By similarity). Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Phosphorylated by SRPK1 at multiple serines in its RS domain via a directional (C- terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds to a docking groove in the large lobe of the kinase domain of SRPK1 and this induces certain structural changes in SRPK1 and/or RRM 2 domain of SRSF1, allowing RRM 2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM 2, which then docks at the docking groove of SRPK1. This also signals RRM 2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed (By similarity). Asymmetrically dimethylated at arginines, probably by PRMT1, methylation promotes localization to nuclear speckles. [Isoform 2]: May be due to intron retention. [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the splicing factor SR family. alternative mRNA splicing, via spliceosome regulation of alternative mRNA splicing, via spliceosome mRNA 5'-splice site recognition in utero embryonic development nucleic acid binding RNA binding mRNA binding protein binding nucleus nucleoplasm spliceosomal complex cytoplasm mRNA processing RNA splicing nuclear speck positive regulation of RNA splicing protein kinase B binding DNA topoisomerase binding mRNA cis splicing, via spliceosome oligodendrocyte differentiation RS domain binding mRNA transport cardiac muscle contraction catalytic step 2 spliceosome liver regeneration exon-exon junction complex uc007kvc.1 uc007kvc.2 uc007kvc.3 uc007kvc.4 
ENSMUST00000139163.8 Gm14634 ENSMUST00000139163.8 predicted gene 14634 (from RefSeq NR_045852.1) ENSMUST00000139163.1 ENSMUST00000139163.2 ENSMUST00000139163.3 ENSMUST00000139163.4 ENSMUST00000139163.5 ENSMUST00000139163.6 ENSMUST00000139163.7 NR_045852 uc009sre.1 uc009sre.2 uc009sre.1 uc009sre.2 
ENSMUST00000139167.3 Gatc ENSMUST00000139167.3 glutamyl-tRNA amidotransferase subunit C (from RefSeq NM_029645.3) ENSMUST00000139167.1 ENSMUST00000139167.2 GATC_MOUSE NM_029645 Q8CBY0 Q8VC59 Q9D8F4 uc008zdr.1 uc008zdr.2 uc008zdr.3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate; Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216; Evidence=; Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. Mitochondrion Belongs to the GatC family. nucleotide binding ATP binding mitochondrion translation regulation of translational fidelity ligase activity carbon-nitrogen ligase activity, with glutamine as amido-N-donor glutamyl-tRNA(Gln) amidotransferase complex mitochondrial translation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity glutaminyl-tRNAGln biosynthesis via transamidation uc008zdr.1 uc008zdr.2 uc008zdr.3 
ENSMUST00000139214.8 4930430E12Rik ENSMUST00000139214.8 4930430E12Rik (from geneSymbol) AK015249 ENSMUST00000139214.1 ENSMUST00000139214.2 ENSMUST00000139214.3 ENSMUST00000139214.4 ENSMUST00000139214.5 ENSMUST00000139214.6 ENSMUST00000139214.7 uc290lan.1 uc290lan.2 uc290lan.1 uc290lan.2 
ENSMUST00000139218.2 Gm16201 ENSMUST00000139218.2 Gm16201 (from geneSymbol) AK078239 ENSMUST00000139218.1 uc012fvx.1 uc012fvx.2 uc012fvx.3 uc012fvx.1 uc012fvx.2 uc012fvx.3 
ENSMUST00000139231.2 Smim30 ENSMUST00000139231.2 small integral membrane protein 30 (from RefSeq NM_001352887.1) ENSMUST00000139231.1 F2Z3Y9 Mavi1 NM_001352887 Q8CF75 SIM30_MOUSE Smim30 uc009ayt.1 uc009ayt.2 uc009ayt.3 uc009ayt.4 Negatively regulates antiviral innate immune responses (PubMed:37656786). Disrupts the interaction of antiviral protein MAVS with innate immune receptor RIGI and inhibits MAVS aggregation, resulting in the repression of type I interferon signaling and innate immune responses (By similarity). Interacts (via transmembrane domain) with antiviral protein MAVS (via transmembrane domain); the interaction disrupts MAVS interaction with RIGI and inhibits MAVS aggregation, resulting in the repression of type I interferon signaling and innate immune responses. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Mitochondrion membrane ; Single-pass type I membrane protein Following challenge with vesicular stomatitis virus (VSV), there is increased production of cytokines including Ifnb1 and Il6, reduced viral burden and higher survival rates than in wild- type mice. Sequence=BAC25005.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc009ayt.1 uc009ayt.2 uc009ayt.3 uc009ayt.4 
ENSMUST00000139253.8 Serf2 ENSMUST00000139253.8 small EDRK-rich factor 2, transcript variant 3 (from RefSeq NR_110986.1) A2ARQ3 ENSMUST00000139253.1 ENSMUST00000139253.2 ENSMUST00000139253.3 ENSMUST00000139253.4 ENSMUST00000139253.5 ENSMUST00000139253.6 ENSMUST00000139253.7 NR_110986 O75918 O88891 P84102 Q9BZH7 SERF2_MOUSE uc008lzd.1 uc008lzd.2 uc008lzd.3 uc008lzd.4 Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (By similarity). Belongs to the SERF family. molecular_function cellular_component nucleus cytosol biological_process uc008lzd.1 uc008lzd.2 uc008lzd.3 uc008lzd.4 
ENSMUST00000139265.3 1700125H03Rik ENSMUST00000139265.3 1700125H03Rik (from geneSymbol) AK015741 ENSMUST00000139265.1 ENSMUST00000139265.2 uc009lwi.1 uc009lwi.2 uc009lwi.3 uc009lwi.4 uc009lwi.1 uc009lwi.2 uc009lwi.3 uc009lwi.4 
ENSMUST00000139288.4 Gm13528 ENSMUST00000139288.4 Gm13528 (from geneSymbol) ENSMUST00000139288.1 ENSMUST00000139288.2 ENSMUST00000139288.3 uc289vhi.1 uc289vhi.2 uc289vhi.3 uc289vhi.4 uc289vhi.1 uc289vhi.2 uc289vhi.3 uc289vhi.4 
ENSMUST00000139309.2 Gm15479 ENSMUST00000139309.2 Gm15479 (from geneSymbol) AK086493 ENSMUST00000139309.1 uc287mow.1 uc287mow.2 uc287mow.1 uc287mow.2 
ENSMUST00000139327.2 Gm11791 ENSMUST00000139327.2 Gm11791 (from geneSymbol) ENSMUST00000139327.1 uc288elg.1 uc288elg.2 uc288elg.1 uc288elg.2 
ENSMUST00000139331.3 Gm15723 ENSMUST00000139331.3 predicted gene 15723 (from RefSeq NR_155864.1) ENSMUST00000139331.1 ENSMUST00000139331.2 NR_155864 uc287uxg.1 uc287uxg.2 uc287uxg.3 uc287uxg.1 uc287uxg.2 uc287uxg.3 
ENSMUST00000139337.3 Gm12258 ENSMUST00000139337.3 predicted gene 12258, transcript variant 2 (from RefSeq NM_001372582.1) ENSMUST00000139337.1 ENSMUST00000139337.2 Gm12258 NM_001372582 Q5NC63 Q5NC63_MOUSE uc287yli.1 uc287yli.2 Nucleus nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc287yli.1 uc287yli.2 
ENSMUST00000139351.9 Sox5os3 ENSMUST00000139351.9 SRY (sex determining region Y)-box 5, opposite strand 3 (from RefSeq NR_040519.1) ENSMUST00000139351.1 ENSMUST00000139351.2 ENSMUST00000139351.3 ENSMUST00000139351.4 ENSMUST00000139351.5 ENSMUST00000139351.6 ENSMUST00000139351.7 ENSMUST00000139351.8 NR_040519 uc009eqr.1 uc009eqr.2 uc009eqr.3 uc009eqr.4 uc009eqr.1 uc009eqr.2 uc009eqr.3 uc009eqr.4 
ENSMUST00000139395.8 Actl6b ENSMUST00000139395.8 actin-like 6B, transcript variant 5 (from RefSeq NR_189586.1) ACL6B_MOUSE Actl6 Arpna Baf53b ENSMUST00000139395.1 ENSMUST00000139395.2 ENSMUST00000139395.3 ENSMUST00000139395.4 ENSMUST00000139395.5 ENSMUST00000139395.6 ENSMUST00000139395.7 NR_189586 Q54A88 Q99MR0 uc009acu.1 uc009acu.2 uc009acu.3 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self- renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth. Essential for neuronal maturation and dendrite development (By similarity). Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (PubMed:22952240, PubMed:26601204).Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A or SMARCD2/BAF60B or SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (ACTB)(PubMed:12368262, PubMed:17640523, PubMed:17920018). Note that the nBAF complex is polymorphic in regard to the ATPase, SMARCA2 and SMARCA4 occupying mutually exclusive positions (PubMed:12368262). May be a component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (By similarity). Nucleus Restricted to the brain and peripheral nervous tissue (at protein level). Present in virtually all neurons in the cerebral neocortex (layers II-VI), hippocampus (CA1-CA3 region and dentate gyrus), cerebellum (molecular, granular and Purkinje cell layers), spinal cord (dorsally and ventrally), dorsal root ganglion, retina and the olfactory bulb (mitral and granule cell layers). Expressed specifically in postmitotic neurons (at protein level). Expression begins near the time of neuronal cell type specification. First apparent at 10.5 dpc in the nervous system, with high levels in the telencephalon and less in the diencephalon, mesencephalon and spinal cord. This pattern of expression persists and becomes more defined at 12.5 dpc and later stages. Detected in dorsal root ganglia, but not in neural crest derivatives that give rise to non-neuronal tissues, including great vessels. Expressed in postmitotic cells in the CNS, but not in actively proliferating precursor cells. At protein level, first detected at 12.5 dpc in nervous tissues. In the developing forebrain, cerebellar primordium and spinal cord, strictly expressed in postmitotic neurons. By retinoic acid of P19 embryonic carcinoma stem cells induced by this treatment to differentiate into neuronal cells. Mice have lethal defects in neuronal development, including defects in activity-dependent dendritic outgrowth. Belongs to the actin family. chromatin binding protein binding nucleus nucleolus chromatin organization chromatin assembly or disassembly chromatin remodeling regulation of transcription from RNA polymerase II promoter nervous system development SWI/SNF complex spinal cord development NuA4 histone acetyltransferase complex ATP-dependent chromatin remodeling histone H4 acetylation nBAF complex uc009acu.1 uc009acu.2 uc009acu.3 
ENSMUST00000139423.2 Gm11815 ENSMUST00000139423.2 Gm11815 (from geneSymbol) ENSMUST00000139423.1 uc290ldf.1 uc290ldf.2 uc290ldf.1 uc290ldf.2 
ENSMUST00000139429.9 E130307A14Rik ENSMUST00000139429.9 E130307A14Rik (from geneSymbol) AK164126 ENSMUST00000139429.1 ENSMUST00000139429.2 ENSMUST00000139429.3 ENSMUST00000139429.4 ENSMUST00000139429.5 ENSMUST00000139429.6 ENSMUST00000139429.7 ENSMUST00000139429.8 uc287qpg.1 uc287qpg.2 uc287qpg.3 uc287qpg.1 uc287qpg.2 uc287qpg.3 
ENSMUST00000139454.3 Gm28035 ENSMUST00000139454.3 Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:30135305, PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2'-3'-cGAMP, thereby promoting transfer of 2'-3'-cGAMP to bystander cells (PubMed:32277911). In contrast, complexes containing LRRC8D inhibit transport of 2'-3'-cGAMP (By similarity). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297). Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (PubMed:31387946, PubMed:32930093). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29371604, PubMed:29773801). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (By similarity). (from UniProt Q80WG5) A2AQZ0 BC048152 ENSMUST00000139454.1 ENSMUST00000139454.2 LRC8A_MOUSE Lrrc8 Lrrc8a Q80WG5 uc289uri.1 uc289uri.2 Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:30135305, PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2'-3'-cGAMP, thereby promoting transfer of 2'-3'-cGAMP to bystander cells (PubMed:32277911). In contrast, complexes containing LRRC8D inhibit transport of 2'-3'-cGAMP (By similarity). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297). Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (PubMed:31387946, PubMed:32930093). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29371604, PubMed:29773801). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (By similarity). Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence=; Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324, ChEBI:CHEBI:16382; Evidence=; Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328, ChEBI:CHEBI:507393; Evidence=; Reaction=L-aspartate(out) = L-aspartate(in); Xref=Rhea:RHEA:66332, ChEBI:CHEBI:29991; Evidence=; Reaction=L-glutamate(out) = L-glutamate(in); Xref=Rhea:RHEA:66336, ChEBI:CHEBI:29985; Evidence=; Reaction=myo-inositol(out) = myo-inositol(in); Xref=Rhea:RHEA:32867, ChEBI:CHEBI:17268; Evidence=; Reaction=2',3'-cGAMP(out) = 2',3'-cGAMP(in); Xref=Rhea:RHEA:66320, ChEBI:CHEBI:143093; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66321; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:66322; Evidence=; Inhibited by (4-[(2-butyl-6,7-dichloro-2- cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid), which plugs the channel like a cork in a bottle by binding in the extracellular selectivity filter and sterically occluding ion conduction. Hexamer; forms a trimer of dimers (PubMed:29769723, PubMed:30775971). Heterohexamer; oligomerizes with other LRRC8 proteins (LRRC8B, LRRC8C, LRRC8D and/or LRRC8E) to form a heterohexamer (PubMed:24782309, PubMed:29769723). Can form homohexamers in vitro, but these have lower conductance than heterohexamers (PubMed:29769723). Detected in a channel complex that contains LRRC8A, LRRC8C and LRRC8E (By similarity). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable). Interact with GRB2 (PubMed:32930093). Q80WG5; Q80WG5: Lrrc8a; NbExp=4; IntAct=EBI-20718010, EBI-20718010; Cell membrane ulti-pass membrane protein sosome membrane ; Multi-pass membrane protein Note=Mainly localizes to the cell membrane, with some intracellular localization to lysosomes. Ubiquitously expressed (PubMed:24725410, PubMed:30135305). High levels detected in the bone marrow; lower levels found in peripheral blood cells (PubMed:14660746, PubMed:15094057, PubMed:24752297). Highly expressed in pancreatic beta cells (PubMed:29773801). The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins. The di-leucine motif is required for lysosomal localization. The cytoplasmic N-terminus preceding the first transmembrane (residues 1-22) regulates volume-regulated anion channel (VRAC) conductance, ion permeability and inactivation gating. N-glycosylated. Note=Defects in Lrrc8a are the cause of ebouriffe (ebo), a spontaneous mutation that causes male sterility (PubMed:8828840, PubMed:28192143, PubMed:30135305). Spermatozoa present in the epididymis display severe malformations, mostly of the tail (PubMed:8828840, PubMed:28192143). A drastic decrease of the spermatid population is observed, whereas spermatogonia and spermatocytes seem moderately affected (PubMed:8828840, PubMed:28192143). Defects are caused by decreased volume-regulated anion channel (VRAC) activity in germ cells (PubMed:30135305). Oogenesis is not affected but embryos derived from ebo/ebo females show early developmental failure (PubMed:30135305). Increased prenatal and postnatal mortality, growth retardation, and multiple tissue abnormalities (PubMed:24752297). B-cell development is slightly impaired, without affecting B-cell function (PubMed:24752297). Mice however show a cell- autonomous early block in thymocyte development and impairs peripheral T-cell expansion and function (PubMed:24752297). Conditional deletion in germ cells leads to abnormal sperm and male infertility: the cytoplasm of late spermatids appears swollen, preventing reduction of the cytoplasm during further development into spermatozoa (PubMed:29880644, PubMed:30135305). Spermatozoa display severely disorganized mitochondrial sheaths in the midpiece region, as well as angulated or coiled flagella, resulting in dramatically reduced sperm motility (PubMed:29880644). Conditional deletion in Sertoli cells does not affect male fertility (PubMed:29880644). Conditional deletion in pancreatic beta cells have normal resting serum glucose levels but impaired glucose tolerance (PubMed:29371604, PubMed:29773801). Conditional deletion in myotubes leads to impaired myoblast differentiation: mice have smaller myofibers, generate less force ex vivo, and display reduced exercise endurance, associated with increased adiposity under basal conditions, and glucose intolerance and insulin resistance when raised on a high-fat diet (PubMed:32930093). Belongs to the LRRC8 family. pre-B cell differentiation volume-sensitive anion channel activity plasma membrane integral component of plasma membrane ion transport anion transport cell volume homeostasis response to osmotic stress cell surface inorganic anion transport taurine transport aspartate transport membrane integral component of membrane cell differentiation protein hexamerization ion channel complex identical protein binding anion transmembrane transport anion channel activity uc289uri.1 uc289uri.2 
ENSMUST00000139455.2 9030204H09Rik ENSMUST00000139455.2 RIKEN cDNA 9030204H09 gene (from RefSeq NR_040618.1) ENSMUST00000139455.1 NR_040618 uc029twy.1 uc029twy.2 uc029twy.1 uc029twy.2 
ENSMUST00000139469.3 Gm16054 ENSMUST00000139469.3 Gm16054 (from geneSymbol) AK132973 ENSMUST00000139469.1 ENSMUST00000139469.2 uc290wrn.1 uc290wrn.2 uc290wrn.3 uc290wrn.1 uc290wrn.2 uc290wrn.3 
ENSMUST00000139497.2 Gm13497 ENSMUST00000139497.2 predicted gene 13497 (from RefSeq NR_040636.1) ENSMUST00000139497.1 NR_040636 uc008jqh.1 uc008jqh.2 uc008jqh.1 uc008jqh.2 
ENSMUST00000139517.9 Sgsm3 ENSMUST00000139517.9 small G protein signaling modulator 3, transcript variant 1 (from RefSeq NM_134091.2) Cip85 ENSMUST00000139517.1 ENSMUST00000139517.2 ENSMUST00000139517.3 ENSMUST00000139517.4 ENSMUST00000139517.5 ENSMUST00000139517.6 ENSMUST00000139517.7 ENSMUST00000139517.8 NM_134091 Q3TCB6 Q8VCZ6 Rutbc3 SGSM3_MOUSE Sgsm3 uc007wwb.1 uc007wwb.2 uc007wwb.3 uc007wwb.4 May play a cooperative role in NF2-mediated growth suppression of cells. Interacts with GJA1. Interaction with GJA1 induces its degradation. Interacts via its RUN domain with the C-terminal region of NF2. Interacts with RAB3A, RAB4A, RAB5A, RAB8A, RAB11A, RAP1A, RAP1B, RAP2A, RAP2B and PDCD6I. No interaction with RAB27A (By similarity). Q8VCZ6; P08050: Gja1; Xeno; NbExp=4; IntAct=EBI-525155, EBI-476947; Cytoplasm Widely expressed. Belongs to the small G protein signaling modulator family. Sequence=BAE42041.1; Type=Erroneous initiation; Evidence=; GTPase activator activity protein binding cytoplasm cytosol gap junction intracellular protein transport cell cycle cell cycle arrest Rab GTPase binding GTPase regulator activity regulation of Rab protein signal transduction Rap protein signal transduction positive regulation of GTPase activity positive regulation of protein catabolic process plasma membrane to endosome transport activation of GTPase activity uc007wwb.1 uc007wwb.2 uc007wwb.3 uc007wwb.4 
ENSMUST00000139560.8 Ndc1 ENSMUST00000139560.8 NDC1 transmembrane nucleoporin, transcript variant 2 (from RefSeq NR_165083.1) ENSMUST00000139560.1 ENSMUST00000139560.2 ENSMUST00000139560.3 ENSMUST00000139560.4 ENSMUST00000139560.5 ENSMUST00000139560.6 ENSMUST00000139560.7 NDC1_MOUSE NR_165083 Q8VCB1 Tmem48 uc008tzt.1 uc008tzt.2 uc008tzt.3 Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity). Interacts with the NUP35/NUP53. Nucleus, nuclear pore complex Nucleus membrane ; Multi-pass membrane protein Note=Central core structure of the nuclear pore complex. Phosphorylated. Belongs to the NDC1 family. nucleus nuclear pore cytoplasm plasma membrane nucleocytoplasmic transport nuclear pore organization synapsis spermatogenesis protein transport actin cytoskeleton membrane integral component of membrane structural constituent of nuclear pore nuclear pore distribution nuclear membrane mRNA transport nuclear pore complex assembly nuclear pore transmembrane ring uc008tzt.1 uc008tzt.2 uc008tzt.3 
ENSMUST00000139576.2 Gm11368 ENSMUST00000139576.2 Gm11368 (from geneSymbol) ENSMUST00000139576.1 uc288lsi.1 uc288lsi.2 uc288lsi.1 uc288lsi.2 
ENSMUST00000139582.9 Usp35 ENSMUST00000139582.9 ubiquitin specific peptidase 35 (from RefSeq NM_001177412.2) ENSMUST00000139582.1 ENSMUST00000139582.2 ENSMUST00000139582.3 ENSMUST00000139582.4 ENSMUST00000139582.5 ENSMUST00000139582.6 ENSMUST00000139582.7 ENSMUST00000139582.8 M0QWN7 M0QWN7_MOUSE NM_001177412 Usp35 uc291stv.1 uc291stv.2 Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity cellular_component ubiquitin-dependent protein catabolic process protein deubiquitination thiol-dependent ubiquitinyl hydrolase activity uc291stv.1 uc291stv.2 
ENSMUST00000139592.3 Scpep1os ENSMUST00000139592.3 serine carboxypeptidase 1, opposite strand (from RefSeq NR_045955.1) ENSMUST00000139592.1 ENSMUST00000139592.2 NR_045955 uc029rnj.1 uc029rnj.2 uc029rnj.1 uc029rnj.2 
ENSMUST00000139612.3 Gm15706 ENSMUST00000139612.3 predicted gene 15706 (from RefSeq NR_045598.2) ENSMUST00000139612.1 ENSMUST00000139612.2 NR_045598 uc291keq.1 uc291keq.2 uc291keq.3 uc291keq.1 uc291keq.2 uc291keq.3 
ENSMUST00000139614.2 Gm11820 ENSMUST00000139614.2 Gm11820 (from geneSymbol) AK139819 ENSMUST00000139614.1 uc290lgj.1 uc290lgj.2 uc290lgj.1 uc290lgj.2 
ENSMUST00000139621.3 1700028N14Rik ENSMUST00000139621.3 1700028N14Rik (from geneSymbol) AK006468 ENSMUST00000139621.1 ENSMUST00000139621.2 uc288ctt.1 uc288ctt.2 uc288ctt.3 uc288ctt.1 uc288ctt.2 uc288ctt.3 
ENSMUST00000139662.2 Dnm3os ENSMUST00000139662.2 dynamin 3, opposite strand (from RefSeq NR_002870.2) ENSMUST00000139662.1 NR_002870 uc007dgf.1 uc007dgf.2 uc007dgf.3 uc007dgf.1 uc007dgf.2 uc007dgf.3 
ENSMUST00000139666.8 Afdn ENSMUST00000139666.8 afadin, adherens junction formation factor, transcript variant 2 (from RefSeq NR_151731.1) AFAD_MOUSE Af6 Afdn ENSMUST00000139666.1 ENSMUST00000139666.2 ENSMUST00000139666.3 ENSMUST00000139666.4 ENSMUST00000139666.5 ENSMUST00000139666.6 ENSMUST00000139666.7 Mllt4 NR_151731 Q9QZQ1 uc008amr.1 uc008amr.2 uc008amr.3 Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (By similarity). May play a key role in the organization of epithelial structures of the embryonic ectoderm (PubMed:10477764). Essential for the organization of adherens junctions (By similarity). Homodimer. Interacts with F-actin, nectin and NECTIN3. Essential for the association of nectin and E-cadherin. Isoform 2/s- afadin does not interact with F-actin. Interacts with ZO-1 and occludin, but probably in an indirect manner. Interacts with RIT1, RIT2, NRXN1 and BCR (By similarity). Interacts with ADAM10; the interaction locks ADAM10 at adherens junctions following ADAM10 recruitment to adherens junctions by TSPAN33 (PubMed:30463011). Cell junction, adherens junction Note=Not found at cell-matrix AJs. Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q9QZQ1-3; Sequence=Displayed; Name=1; Synonyms=l-afadin; IsoId=Q9QZQ1-2; Sequence=VSP_026731; Name=2; Synonyms=s-afadin; IsoId=Q9QZQ1-1; Sequence=Not described; Isoform 1 is expressed only in a restricted set of epithelial structures during early embryogenesis. Highly expressed at restricted set of epithelial structures and highly concentrated at their junctional complex regions. At 6.5 dpc, localized at the most apical regions of cell-cell adhesion sites of the entire embryonic ectoderm; not detected in the extraembryonic regions. At 7.0 dpc, expressed in the primitive streak and the migrating paraxial mesoderm. At 7.5 dpc, highly expressed at the junctional complex regions in the primitive streak region (neuroepithelium) and the neural fold/grove region, but hardly detected in other areas of the ectoderm. By 8.5 dpc, highly expressed in the tail bud, somites and the paraxial mesoderm, concentrated at the junctional complex regions in neural tube, somites and pericardioperitoneal canal. Mice show developmental defects at stages during and after gastrulation, including disorganization of the ectoderm, impaired migration of the mesoderm and loss of somites and other structures derived from both the ectoderm and mesoderm. Cell-cell adherens juntions and tight junctions are improperly organized in the ectoderm-derived cells. No redundancy exists in the function of afadin during gastrulation. protein binding nucleoplasm cytoplasm cytosol plasma membrane cell-cell junction adherens junction cell-cell adherens junction cell adhesion signal transduction positive regulation of gene expression nuclear speck Ras GTPase binding telencephalon development cerebral cortex development positive regulation of cell-cell adhesion cell junction LIM domain binding negative regulation of cell migration axon regulation of protein localization adherens junction maintenance somatodendritic compartment apical junction complex positive regulation of GTPase activity cell-cell contact zone cell-cell adhesion mediated by cadherin apical part of cell pore complex pore complex assembly brain morphogenesis homeostasis of number of cells positive regulation of dendrite morphogenesis cell adhesion molecule binding actin filament binding radial glial cell differentiation neuroepithelial cell differentiation positive regulation of dendritic spine morphogenesis occluding junction regulation of oligodendrocyte progenitor proliferation bicellular tight junction assembly establishment of endothelial intestinal barrier protein localization to cell junction positive regulation of dendrite extension positive regulation of cell-cell adhesion mediated by cadherin excitatory synapse uc008amr.1 uc008amr.2 uc008amr.3 
ENSMUST00000139677.2 Gm14453 ENSMUST00000139677.2 Gm14453 (from geneSymbol) ENSMUST00000139677.1 uc290cyn.1 uc290cyn.2 uc290cyn.1 uc290cyn.2 
ENSMUST00000139685.8 Rpl22 ENSMUST00000139685.8 ribosomal protein L22, transcript variant 5 (from RefSeq NR_102292.2) ENSMUST00000139685.1 ENSMUST00000139685.2 ENSMUST00000139685.3 ENSMUST00000139685.4 ENSMUST00000139685.5 ENSMUST00000139685.6 ENSMUST00000139685.7 NR_102292 Q4VAG4 Q4VAG4_MOUSE Rpl22 uc290seu.1 uc290seu.2 Component of the large ribosomal subunit. Cytoplasm Belongs to the eukaryotic ribosomal protein eL22 family. structural constituent of ribosome nucleus cytoplasm ribosome translation ribonucleoprotein complex uc290seu.1 uc290seu.2 
ENSMUST00000139695.2 Gm14798 ENSMUST00000139695.2 Gm14798 (from geneSymbol) AK038802 ENSMUST00000139695.1 uc292pla.1 uc292pla.2 uc292pla.1 uc292pla.2 
ENSMUST00000139701.2 Gm4876 ENSMUST00000139701.2 predicted gene 4876 (from RefSeq NR_153844.1) ENSMUST00000139701.1 NR_153844 uc009azj.1 uc009azj.2 uc009azj.3 uc009azj.1 uc009azj.2 uc009azj.3 
ENSMUST00000139725.8 Mitd1 ENSMUST00000139725.8 MIT, microtubule interacting and transport, domain containing 1, transcript variant 2 (from RefSeq NM_001356262.1) ENSMUST00000139725.1 ENSMUST00000139725.2 ENSMUST00000139725.3 ENSMUST00000139725.4 ENSMUST00000139725.5 ENSMUST00000139725.6 ENSMUST00000139725.7 MITD1_MOUSE NM_001356262 Q8VDV8 Q9DB13 uc287hll.1 uc287hll.2 Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex. Homodimer. Interacts (via MIT domain) with CHMP1A, CHMP1B, CHMP2A and IST1 (By similarity). Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Midbody Membrane ; Peripheral membrane protein ; Cytoplasmic side Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides (By similarity). The C-terminal domain interacts with lipid membranes containing acidic phosphoinositides and is required for location at the midbody. The MIT domain interacts with the MIT-interacting motifs of several components of the ESCRT-III complex. Sequence=BAB23964.1; Type=Frameshift; Evidence=; mitotic cytokinesis endosome cell cycle membrane extrinsic component of membrane protein domain specific binding midbody late endosome membrane negative regulation of protein binding phosphatidylinositol binding protein homodimerization activity intracellular membrane-bounded organelle cell division uc287hll.1 uc287hll.2 
ENSMUST00000139751.2 AY512931 ENSMUST00000139751.2 cDNA sequence AY512931 (from RefSeq NR_033588.1) ENSMUST00000139751.1 NR_033588 uc009lop.1 uc009lop.2 uc009lop.1 uc009lop.2 
ENSMUST00000139752.3 Gm11574 ENSMUST00000139752.3 Gm11574 (from geneSymbol) AK158258 ENSMUST00000139752.1 ENSMUST00000139752.2 uc288btg.1 uc288btg.2 uc288btg.3 uc288btg.1 uc288btg.2 uc288btg.3 
ENSMUST00000139771.3 4930577N17Rik ENSMUST00000139771.3 RIKEN cDNA 4930577N17 gene (from RefSeq NR_073429.1) ENSMUST00000139771.1 ENSMUST00000139771.2 NR_073429 uc008pdu.1 uc008pdu.2 uc008pdu.3 uc008pdu.4 uc008pdu.1 uc008pdu.2 uc008pdu.3 uc008pdu.4 
ENSMUST00000139780.3 Rgma ENSMUST00000139780.3 Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA- ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG- PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1- AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. (from UniProt Q6PCX7) BC023870 ENSMUST00000139780.1 ENSMUST00000139780.2 Q6PCX7 Q7TQ34 Q8CIH6 RGMA_MOUSE uc009hrb.1 uc009hrb.2 uc009hrb.3 Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA- ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG- PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1- AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. Interacts with NEO1, BMP2 and BMP4. Cell membrane ; Lipid-anchor, GPI- anchor Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PCX7-1; Sequence=Displayed; Name=2; IsoId=Q6PCX7-2; Sequence=VSP_011316; Expressed in gradient in periventricular layers of the developing nervous system. In adult, expressed in scattered cells throughout the brain. Expressed in the early developing nervous system, with the exception of prominent gaps in the mid-hindbrain and the fore- midbrain boundaries. By 10.5 dpc, expression in the nervous system decreases slightly and a segmented pattern of expression appears, marking the ventral sites of somitic buds. At that stage, the expression shows a strong dorsal to ventral gradient. In the neural tubes, strong expression is detected at the level of the floor plate and in the medial portion of the neural tubes. Lower expression is detected in the dorsal neural tube and the ventral aspect corresponding to the area of motoneuron differentiation. In the developing eye, expressed in the perioptic mesenchyme. Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. Belongs to the repulsive guidance molecule (RGM) family. neural tube closure positive regulation of protein phosphorylation receptor binding protein binding endoplasmic reticulum plasma membrane cell surface regulation of neuron projection development positive regulation of neuron projection development negative regulation of neuron projection development coreceptor activity membrane BMP signaling pathway regulation of BMP signaling pathway neuron projection development anchored component of membrane neuron projection positive regulation of GTPase activity positive regulation of transcription from RNA polymerase II promoter negative regulation of collateral sprouting negative regulation of axon regeneration positive regulation of membrane protein ectodomain proteolysis negative regulation of receptor binding transferrin receptor binding uc009hrb.1 uc009hrb.2 uc009hrb.3 
ENSMUST00000139783.2 Tafa3 ENSMUST00000139783.2 TAFA chemokine like family member 3 (from RefSeq NM_183224.3) ENSMUST00000139783.1 Fam19a3 NM_183224 Q147Z7 Q7TPG6 TAFA3_MOUSE uc008quj.1 uc008quj.2 uc008quj.3 uc008quj.4 This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK078681.1, BC118531.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Plays a role in the regulation of microglia polarization. Secreted Highly expressed in brain, in regions such as the hippocampus, the habenular, thalamic nuclei and hypophysial pars tuberalis (PubMed:25595455). Expression levels in the hypophysial pars tuberalis vary between day and night: they are low at mid-day and high at mid-night. The expression in the other regions do not display a day/night difference (PubMed:22426341). By ischemia. Up-regulated in the microglia in the middle cerebral artery occlusion (MCAO), expression reduced back to control level at 14 days after MCAO. Belongs to the TAFA family. extracellular region extracellular space signal transduction receptor agonist activity negative regulation of microglial cell activation positive regulation of microglial cell activation uc008quj.1 uc008quj.2 uc008quj.3 uc008quj.4 
ENSMUST00000139791.3 Gm15700 ENSMUST00000139791.3 Gm15700 (from geneSymbol) ENSMUST00000139791.1 ENSMUST00000139791.2 uc291qak.1 uc291qak.2 uc291qak.1 uc291qak.2 
ENSMUST00000139793.8 Abhd13 ENSMUST00000139793.8 abhydrolase domain containing 13, transcript variant 1 (from RefSeq NM_026868.1) ABHDD_MOUSE Abhd13 ENSMUST00000139793.1 ENSMUST00000139793.2 ENSMUST00000139793.3 ENSMUST00000139793.4 ENSMUST00000139793.5 ENSMUST00000139793.6 ENSMUST00000139793.7 NM_026868 Q80UX8 Q8BXS1 Q9D0V5 uc012fzf.1 uc012fzf.2 uc012fzf.3 uc012fzf.4 Membrane ; Single-pass type II membrane protein Belongs to the serine esterase family. Sequence=BAC31905.1; Type=Erroneous initiation; Evidence=; protein depalmitoylation cytoplasm palmitoyl-(protein) hydrolase activity membrane integral component of membrane hydrolase activity dendrite cytoplasm uc012fzf.1 uc012fzf.2 uc012fzf.3 uc012fzf.4 
ENSMUST00000139808.8 D030018L15Rik ENSMUST00000139808.8 RIKEN cDNA D030018L15 gene, transcript variant 2 (from RefSeq NR_126493.1) ENSMUST00000139808.1 ENSMUST00000139808.2 ENSMUST00000139808.3 ENSMUST00000139808.4 ENSMUST00000139808.5 ENSMUST00000139808.6 ENSMUST00000139808.7 NR_126493 uc007xjx.1 uc007xjx.2 uc007xjx.3 uc007xjx.4 uc007xjx.1 uc007xjx.2 uc007xjx.3 uc007xjx.4 
ENSMUST00000139822.4 4930558J22Rik ENSMUST00000139822.4 4930558J22Rik (from geneSymbol) AK133404 ENSMUST00000139822.1 ENSMUST00000139822.2 ENSMUST00000139822.3 uc007puv.1 uc007puv.2 uc007puv.3 uc007puv.1 uc007puv.2 uc007puv.3 
ENSMUST00000139828.3 Pramel53 ENSMUST00000139828.3 PRAME like 53, transcript variant 1 (from RefSeq NM_001406260.1) ENSMUST00000139828.1 ENSMUST00000139828.2 K9J7D1 K9J7D1_MOUSE NM_001406260 Pramel53 Pramel54 uc290xfc.1 uc290xfc.2 uc290xfc.3 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xfc.1 uc290xfc.2 uc290xfc.3 
ENSMUST00000139835.4 Gm11266 ENSMUST00000139835.4 predicted gene 11266 (from RefSeq NR_137202.1) ENSMUST00000139835.1 ENSMUST00000139835.2 ENSMUST00000139835.3 NR_137202 uc290nlv.1 uc290nlv.2 uc290nlv.3 uc290nlv.4 uc290nlv.1 uc290nlv.2 uc290nlv.3 uc290nlv.4 
ENSMUST00000139848.8 Rasd2 ENSMUST00000139848.8 RASD family, member 2 (from RefSeq NM_029182.1) ENSMUST00000139848.1 ENSMUST00000139848.2 ENSMUST00000139848.3 ENSMUST00000139848.4 ENSMUST00000139848.5 ENSMUST00000139848.6 ENSMUST00000139848.7 NM_029182 P63032 Q9WVD3 RHES_MOUSE uc009mhg.1 uc009mhg.2 uc009mhg.3 GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. Monomer (Potential). Interacts with PIK3CA and UBE2I. Interacts with GNB1, GNB2 and GNB3 (By similarity). Cell membrane ; Lipid-anchor Highly expressed in brain; prominently in the striatum and weakly in kidney, thyroid, lung, heart and testis. Not expressed in liver. Expressed in pancreatic cell lines and in a embryonic stem cell line. Expressed in the brain from 13.5 dpc. Down-regulated in hypothyroid conditions and up-regulated by glibenclamide. Farnesylated. Farnesylation is required for membrane targeting (By similarity). Shows behavioral abnormalities, displaying a gender-dependent increase in anxiety levels and a clear motor coordination deficit and a mild hyperactive phenotype. Mice are more sensitive to D2 receptor stimulation and have decreased body weight. Belongs to the small GTPase superfamily. RasD family. Sequence=AAH26377.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence=; nucleotide binding synaptic transmission, dopaminergic GTPase activity GTP binding plasma membrane signal transduction behavior locomotory behavior membrane negative regulation of protein ubiquitination ubiquitin conjugating enzyme binding G-protein beta-subunit binding positive regulation of protein sumoylation phosphatidylinositol 3-kinase binding regulation of cAMP-mediated signaling positive regulation of protein kinase B signaling uc009mhg.1 uc009mhg.2 uc009mhg.3 
ENSMUST00000139851.2 Gm15606 ENSMUST00000139851.2 Gm15606 (from geneSymbol) ENSMUST00000139851.1 uc292fki.1 uc292fki.2 uc292fki.1 uc292fki.2 
ENSMUST00000139864.2 4933408N05Rik ENSMUST00000139864.2 RIKEN cDNA 4933408N05 gene (from RefSeq NR_045831.2) ENSMUST00000139864.1 NR_045831 uc292dik.1 uc292dik.2 uc292dik.1 uc292dik.2 
ENSMUST00000139874.3 Gm15295 ENSMUST00000139874.3 Gm15295 (from geneSymbol) ENSMUST00000139874.1 ENSMUST00000139874.2 uc292qvv.1 uc292qvv.2 uc292qvv.3 uc292qvv.1 uc292qvv.2 uc292qvv.3 
ENSMUST00000139941.2 Gm11713 ENSMUST00000139941.2 Gm11713 (from geneSymbol) ENSMUST00000139941.1 uc288dcl.1 uc288dcl.2 uc288dcl.1 uc288dcl.2 
ENSMUST00000139948.2 Arhgap15os ENSMUST00000139948.2 Rho GTPase activating protein 15, opposite strand (from RefSeq NR_040622.1) ENSMUST00000139948.1 NR_040622 uc029txa.1 uc029txa.2 uc029txa.1 uc029txa.2 
ENSMUST00000139966.8 Nsd3 ENSMUST00000139966.8 Nucleus (from UniProt D3Z197) BC167226 D3Z197 D3Z197_MOUSE ENSMUST00000139966.1 ENSMUST00000139966.2 ENSMUST00000139966.3 ENSMUST00000139966.4 ENSMUST00000139966.5 ENSMUST00000139966.6 ENSMUST00000139966.7 Nsd3 Whsc1l1 uc291yxf.1 uc291yxf.2 Nucleus nucleus histone-lysine N-methyltransferase activity histone lysine methylation metal ion binding uc291yxf.1 uc291yxf.2 
ENSMUST00000139976.9 Plch2 ENSMUST00000139976.9 phospholipase C, eta 2, transcript variant 1 (from RefSeq NM_175556.5) ENSMUST00000139976.1 ENSMUST00000139976.2 ENSMUST00000139976.3 ENSMUST00000139976.4 ENSMUST00000139976.5 ENSMUST00000139976.6 ENSMUST00000139976.7 ENSMUST00000139976.8 F7C3A0 F7C3A0_MOUSE F8VQ50 NM_175556 Plch2 uc056zyq.1 uc056zyq.2 uc056zyq.3 Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33180; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; phosphatidylinositol phospholipase C activity phospholipase C activity calcium ion binding lipid metabolic process signal transduction phosphoric diester hydrolase activity lipid catabolic process hydrolase activity intracellular signal transduction uc056zyq.1 uc056zyq.2 uc056zyq.3 
ENSMUST00000140000.2 Gm15983 ENSMUST00000140000.2 Gm15983 (from geneSymbol) AK140616 ENSMUST00000140000.1 uc289cgf.1 uc289cgf.2 uc289cgf.1 uc289cgf.2 
ENSMUST00000140009.2 Gm13905 ENSMUST00000140009.2 Gm13905 (from geneSymbol) ENSMUST00000140009.1 uc289ytr.1 uc289ytr.2 uc289ytr.1 uc289ytr.2 
ENSMUST00000140012.8 Pgbd5 ENSMUST00000140012.8 piggyBac transposable element derived 5 (from RefSeq NM_171824.3) D3YZI9 D3Z077 E9PUA8 ENSMUST00000140012.1 ENSMUST00000140012.2 ENSMUST00000140012.3 ENSMUST00000140012.4 ENSMUST00000140012.5 ENSMUST00000140012.6 ENSMUST00000140012.7 NM_171824 PGBD5_MOUSE Pgbd5 Q52KE6 uc292eaj.1 uc292eaj.2 The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.2522.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Transposase that mediates sequence-specific genomic rearrangements. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=D3YZI9-1; Sequence=Displayed; Name=2; IsoId=D3YZI9-2; Sequence=VSP_059132; Expressed in the brain (at protein level). Has been domesticated very early in vertebrate evolution, approximately 500 million years ago, in the common ancestor of cephalochordates and vertebrates. Sequence=AAH94384.1; Type=Miscellaneous discrepancy; Note=20-nucleotide gap within coding exon 1.; Evidence=; nuclease activity endonuclease activity transposase activity nucleus hydrolase activity transposition nucleic acid phosphodiester bond hydrolysis non-replicative transposition, DNA-mediated uc292eaj.1 uc292eaj.2 
ENSMUST00000140021.2 Gm14565 ENSMUST00000140021.2 Gm14565 (from geneSymbol) AK135343 ENSMUST00000140021.1 uc292nvr.1 uc292nvr.2 uc292nvr.1 uc292nvr.2 
ENSMUST00000140044.8 Gm15941 ENSMUST00000140044.8 predicted gene 15941 (from RefSeq NR_045283.1) ENSMUST00000140044.1 ENSMUST00000140044.2 ENSMUST00000140044.3 ENSMUST00000140044.4 ENSMUST00000140044.5 ENSMUST00000140044.6 ENSMUST00000140044.7 NR_045283 uc007vnj.1 uc007vnj.2 uc007vnj.3 uc007vnj.4 uc007vnj.1 uc007vnj.2 uc007vnj.3 uc007vnj.4 
ENSMUST00000140061.8 Maskbp3 ENSMUST00000140061.8 Maskbp3 (from geneSymbol) BC016604 ENSMUST00000140061.1 ENSMUST00000140061.2 ENSMUST00000140061.3 ENSMUST00000140061.4 ENSMUST00000140061.5 ENSMUST00000140061.6 ENSMUST00000140061.7 F6RUI8 F6RUI8_MOUSE Maskbp3 uc289osi.1 uc289osi.2 cytoplasm innate immune response uc289osi.1 uc289osi.2 
ENSMUST00000140076.2 Ppat ENSMUST00000140076.2 phosphoribosyl pyrophosphate amidotransferase (from RefSeq NM_172146.2) ENSMUST00000140076.1 NM_172146 PUR1_MOUSE Ppat Q3TKC5 Q3TUW2 Q3UGU3 Q8CIH9 uc008xvm.1 uc008xvm.2 uc008xvm.3 uc008xvm.4 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. Reaction=5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5- phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine; Xref=Rhea:RHEA:14905, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58359, ChEBI:CHEBI:58681; EC=2.4.2.14; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:14907; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster per subunit. ; Purine metabolism; IMP biosynthesis via de novo pathway; N(1)- (5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1- diphosphate: step 1/2. Homotetramer. In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. G1/S transition of mitotic cell cycle kidney development amidophosphoribosyltransferase activity purine nucleotide biosynthetic process 'de novo' IMP biosynthetic process glutamine catabolic process lactation purine nucleobase biosynthetic process nucleoside metabolic process purine ribonucleoside monophosphate biosynthetic process transferase activity transferase activity, transferring glycosyl groups ribose phosphate metabolic process animal organ regeneration cellular response to insulin stimulus cellular response to drug response to drug metal ion binding protein homotetramerization iron-sulfur cluster binding maternal process involved in female pregnancy uc008xvm.1 uc008xvm.2 uc008xvm.3 uc008xvm.4 
ENSMUST00000140079.8 St18 ENSMUST00000140079.8 suppression of tumorigenicity 18, transcript variant 1 (from RefSeq NM_001244692.1) ENSMUST00000140079.1 ENSMUST00000140079.2 ENSMUST00000140079.3 ENSMUST00000140079.4 ENSMUST00000140079.5 ENSMUST00000140079.6 ENSMUST00000140079.7 Kiaa0535 NM_001244692 Q3UH00 Q3URH9 Q3UVB9 Q3UZN9 Q80TY4 Q811B4 Q8K098 ST18_MOUSE uc007afw.1 uc007afw.2 uc007afw.3 Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Nucleus Belongs to the MYT1 family. Sequence=AAH32273.1; Type=Erroneous initiation; Evidence=; Sequence=BAC65585.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated zinc ion binding negative regulation of cell proliferation protein-DNA complex tumor necrosis factor-mediated signaling pathway positive regulation of transcription from RNA polymerase II promoter metal ion binding interleukin-6-mediated signaling pathway interleukin-1-mediated signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway uc007afw.1 uc007afw.2 uc007afw.3 
ENSMUST00000140080.2 Gm12945 ENSMUST00000140080.2 Gm12945 (from geneSymbol) AK146848 ENSMUST00000140080.1 uc290pwb.1 uc290pwb.2 uc290pwb.1 uc290pwb.2 
ENSMUST00000140087.2 Gm15788 ENSMUST00000140087.2 Gm15788 (from geneSymbol) ENSMUST00000140087.1 uc290yem.1 uc290yem.2 uc290yem.1 uc290yem.2 
ENSMUST00000140104.2 Gm13441 ENSMUST00000140104.2 Gm13441 (from geneSymbol) AK005985 ENSMUST00000140104.1 uc289uyh.1 uc289uyh.2 uc289uyh.1 uc289uyh.2 
ENSMUST00000140105.9 F730043M19Rik ENSMUST00000140105.9 RIKEN cDNA F730043M19 gene (from RefSeq NR_015602.3) ENSMUST00000140105.1 ENSMUST00000140105.2 ENSMUST00000140105.3 ENSMUST00000140105.4 ENSMUST00000140105.5 ENSMUST00000140105.6 ENSMUST00000140105.7 ENSMUST00000140105.8 NR_015602 uc007nil.1 uc007nil.2 uc007nil.3 uc007nil.1 uc007nil.2 uc007nil.3 
ENSMUST00000140113.2 Gm13026 ENSMUST00000140113.2 Gm13026 (from geneSymbol) ENSMUST00000140113.1 uc290rfw.1 uc290rfw.2 uc290rfw.1 uc290rfw.2 
ENSMUST00000140116.2 Gm16076 ENSMUST00000140116.2 Gm16076 (from geneSymbol) ENSMUST00000140116.1 uc287iyt.1 uc287iyt.2 uc287iyt.1 uc287iyt.2 
ENSMUST00000140185.4 2700033N17Rik ENSMUST00000140185.4 2700033N17Rik (from geneSymbol) ENSMUST00000140185.1 ENSMUST00000140185.2 ENSMUST00000140185.3 KY467886 uc008lra.1 uc008lra.2 uc008lra.3 uc008lra.4 uc008lra.5 uc008lra.6 uc008lra.1 uc008lra.2 uc008lra.3 uc008lra.4 uc008lra.5 uc008lra.6 
ENSMUST00000140203.2 Gm11548 ENSMUST00000140203.2 predicted gene 11548 (from RefSeq NR_040590.1) ENSMUST00000140203.1 NR_040590 uc029ulj.1 uc029ulj.2 uc029ulj.1 uc029ulj.2 
ENSMUST00000140208.2 ENSMUSG00000121666 ENSMUST00000140208.2 ENSMUSG00000121666 (from geneSymbol) BC016624 ENSMUST00000140208.1 uc292rgz.1 uc292rgz.2 uc292rgz.1 uc292rgz.2 
ENSMUST00000140212.8 Homer3 ENSMUST00000140212.8 homer scaffolding protein 3, transcript variant 2 (from RefSeq NM_011984.2) D3Z6N9 ENSMUST00000140212.1 ENSMUST00000140212.2 ENSMUST00000140212.3 ENSMUST00000140212.4 ENSMUST00000140212.5 ENSMUST00000140212.6 ENSMUST00000140212.7 HOME3_MOUSE Homer3 NM_011984 Q99JP6 Q9Z215 uc009lzs.1 uc009lzs.2 uc009lzs.3 uc009lzs.4 Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). Tetramer (By similarity). Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization. Interacts with NFATC2; interaction is calcium independent; interaction competes with PPP3CA for NFATC2 binding; interaction is reduced by AKT activation (PubMed:18218901). Interacts with NFATC1 and NFATC4. Interacts with SHANK1; forms a high-order complex at least composed of SHANK1 and HOMER3; the complex formation is regulated by CAMK2A- mediated phosphorylation (By similarity). Q99JP6; Q14517: FAT1; Xeno; NbExp=2; IntAct=EBI-6272061, EBI-1171918; Cytoplasm Postsynaptic density Synapse Note=Postsynaptic density of neuronal cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99JP6-1; Sequence=Displayed; Name=2; IsoId=Q99JP6-2; Sequence=VSP_009078; Expressed in the cerebellum, hippocampus, lung and thymus. The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3. Knockout mice show severe autoimmune phenotypes, with lymphocyte infiltration of multiple organs and hyperplasia in lymph nodes by 10 weeks of age. Belongs to the Homer family. protein binding cytoplasm cytosol plasma membrane G-protein coupled glutamate receptor signaling pathway protein C-terminus binding postsynaptic density membrane protein domain specific binding cell junction dendrite negative regulation of interleukin-2 production G-protein coupled glutamate receptor binding identical protein binding neuron projection basal part of cell synapse postsynaptic membrane negative regulation of calcineurin-NFAT signaling cascade regulation of postsynaptic neurotransmitter receptor activity glutamatergic synapse regulation of store-operated calcium entry uc009lzs.1 uc009lzs.2 uc009lzs.3 uc009lzs.4 
ENSMUST00000140238.2 Gm13919 ENSMUST00000140238.2 Gm13919 (from geneSymbol) AK079670 ENSMUST00000140238.1 uc008lhs.1 uc008lhs.2 uc008lhs.3 uc008lhs.1 uc008lhs.2 uc008lhs.3 
ENSMUST00000140239.4 Cers1 ENSMUST00000140239.4 ceramide synthase 1 (from RefSeq NM_138647.3) CERS1_MOUSE Cers1 ENSMUST00000140239.1 ENSMUST00000140239.2 ENSMUST00000140239.3 Lass1 NM_138647 P27545 Uog-1 Uog1 uc292aof.1 uc292aof.2 This gene encodes a ceramide synthase enzyme, which catalyzes the synthesis of ceramide, the hydrophobic moiety of sphingolipids. The encoded enzyme synthesizes 18-carbon (C18) ceramide in brain neurons. Mice lacking a functional copy of this gene exhibit impaired cerebellar development, locomotion and motor coordination. This protein is transcribed from a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC056973.1, AK053885.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## bicistronic transcript :: PMID: 2034669 NMD candidate :: PMID: 2034669 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:12105227, PubMed:16951403, PubMed:17977534, PubMed:18541923, PubMed:30605666). Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity. Protects from diet-induced obesity by suppressing the uptake of glucose in multiple organs in a FGF21- dependent way (PubMed:30605666). Generates C18 ceramides in the brain, playing a critical role in cerebellar development and Purkinje cell function (PubMed:21625621). In response to cellular stress mediates mitophagy, a known defense mechanism against cell transformation and aging. Upon mitochondria fission, generates C18 ceramides that anchor lipidated MAP1LC3B/LC3B-II autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria (By similarity). Reaction=a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl- sphingoid base + CoA + H(+); Xref=Rhea:RHEA:61476, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:84410, ChEBI:CHEBI:144711; EC=2.3.1.299; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61477; Evidence= Reaction=octadecanoyl-CoA + sphinganine = CoA + H(+) + N- (octadecanoyl)-sphinganine; Xref=Rhea:RHEA:36547, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57817, ChEBI:CHEBI:67033; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36548; Evidence= Reaction=hexadecasphinganine + octadecanoyl-CoA = CoA + H(+) + N- octadecanoylhexadecasphinganine; Xref=Rhea:RHEA:43044, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:71009, ChEBI:CHEBI:82811; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43045; Evidence=; Reaction=octadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N- octadecanoylsphing-4-enine; Xref=Rhea:RHEA:36691, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57756, ChEBI:CHEBI:72961; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36692; Evidence=; Reaction=heptadecasphing-4-enine + octadecanoyl-CoA = CoA + H(+) + N- octadecanoyl-heptadecasphing-4-enine; Xref=Rhea:RHEA:67596, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:74166, ChEBI:CHEBI:172405; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67597; Evidence=; Reaction=2-hydroxyoctadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2- hydroxyoctadecanoyl)-sphinganine; Xref=Rhea:RHEA:36615, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:67034, ChEBI:CHEBI:74116; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36616; Evidence=; Reaction=eicosanoyl-CoA + sphinganine = CoA + H(+) + N- eicosanoylsphinganine; Xref=Rhea:RHEA:36555, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:57817, ChEBI:CHEBI:67027; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36556; Evidence=; Inhibited by fumonisin B1. Kinetic parameters: KM=2.5 uM for sphinganine ; Lipid metabolism; sphingolipid metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Expressed in brain, skeletal muscle, heart and perigonadal white adipose tissue. Up-regulated in skeletal muscle in response to high-fat diet. Acetylated (PubMed:26620563). Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation (PubMed:26620563). Note=Defects in CERS1 cause cerebellar ataxia and Purkinje cell degeneration. Two mouse strains flincher (fln) and toppler (to) carry spontaneous recessive mutations at the TLC domain of CERS1, resulting in complete loss of the catalytic activity associated with a reduction in sphingolipid biosynthesis and accumulation of lipofuscin in many brain regions. This protein is produced by a bicistronic gene which also produces the GDF1 protein from a non-overlapping reading frame. protein binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process sphingolipid metabolic process brain development membrane integral component of membrane transferase activity sphingolipid biosynthetic process cellular response to drug cellular response to mycotoxin intracellular membrane-bounded organelle ceramide biosynthetic process sphingosine N-acyltransferase activity negative regulation of telomerase activity cellular response to UV-A cellular response to dithiothreitol uc292aof.1 uc292aof.2 
ENSMUST00000140267.10 Tmem134 ENSMUST00000140267.10 transmembrane protein 134, transcript variant 1 (from RefSeq NM_001078649.1) ENSMUST00000140267.1 ENSMUST00000140267.2 ENSMUST00000140267.3 ENSMUST00000140267.4 ENSMUST00000140267.5 ENSMUST00000140267.6 ENSMUST00000140267.7 ENSMUST00000140267.8 ENSMUST00000140267.9 NM_001078649 Q3TLG9 Q8C1M3 Q8R0J4 Q9CR66 TM134_MOUSE uc289qat.1 uc289qat.2 Membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R0J4-1; Sequence=Displayed; Name=2; IsoId=Q8R0J4-2; Sequence=VSP_023456; Name=3; IsoId=Q8R0J4-3; Sequence=VSP_023455; Belongs to the TMEM134/TMEM230 family. molecular_function cytoplasm biological_process membrane integral component of membrane perinuclear region of cytoplasm uc289qat.1 uc289qat.2 
ENSMUST00000140273.2 Gm11769 ENSMUST00000140273.2 Gm11769 (from geneSymbol) AK085311 ENSMUST00000140273.1 uc288edx.1 uc288edx.2 uc288edx.1 uc288edx.2 
ENSMUST00000140295.8 Sntg1 ENSMUST00000140295.8 syntrophin, gamma 1, transcript variant 1 (from RefSeq NM_027671.5) E9Q0U6 ENSMUST00000140295.1 ENSMUST00000140295.2 ENSMUST00000140295.3 ENSMUST00000140295.4 ENSMUST00000140295.5 ENSMUST00000140295.6 ENSMUST00000140295.7 NM_027671 Q8BNW6 Q8BNW6_MOUSE Sntg1 uc007agh.1 uc007agh.2 uc007agh.3 uc007agh.4 Cytoplasm, cytoskeleton Belongs to the syntrophin family. structural molecule activity cytoplasm cytoskeleton protein C-terminus binding ruffle membrane uc007agh.1 uc007agh.2 uc007agh.3 uc007agh.4 
ENSMUST00000140298.2 Gm12766 ENSMUST00000140298.2 Gm12766 (from geneSymbol) AK077242 ENSMUST00000140298.1 uc291okw.1 uc291okw.2 uc291okw.1 uc291okw.2 
ENSMUST00000140299.3 Rxylt1 ENSMUST00000140299.3 ribitol xylosyltransferase 1, transcript variant 1 (from RefSeq NM_153059.2) ENSMUST00000140299.1 ENSMUST00000140299.2 NM_153059 Q8R566 Q8VDX6 RXLT1_MOUSE Rxylt1 Tmem5 uc007hgd.1 uc007hgd.2 uc007hgd.3 Acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4- xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O- mannosyl glycan. Participates in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Reaction=3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc- (1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O- [beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D- GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP; Xref=Rhea:RHEA:57880, Rhea:RHEA-COMP:15021, Rhea:RHEA-COMP:15023, ChEBI:CHEBI:15378, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:142403, ChEBI:CHEBI:142405; EC=2.4.2.61; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57881; Evidence=; Protein modification; protein glycosylation. Forms a complex composed of FKTN/fukutin, FKRP and RXYLT1/TMEM5. Golgi apparatus membrane ; Single-pass type II membrane protein Belongs to the RXYLT1 family. Golgi membrane nucleoplasm Golgi apparatus protein glycosylation membrane integral component of membrane transferase activity protein O-linked mannosylation uc007hgd.1 uc007hgd.2 uc007hgd.3 
ENSMUST00000140300.2 Btbd35f3 ENSMUST00000140300.2 BTB domain containing 35, family member 3 (from RefSeq NM_001243001.1) A2CGC2 A2CGC2_MOUSE Btbd35f3 Btbd35f4 ENSMUST00000140300.1 NM_001243001 uc009skn.1 uc009skn.2 uc009skn.3 uc009skn.4 molecular_function cellular_component biological_process uc009skn.1 uc009skn.2 uc009skn.3 uc009skn.4 
ENSMUST00000140307.4 4933439K11Rik ENSMUST00000140307.4 RIKEN cDNA 4933439K11 gene (from RefSeq NR_040558.1) ENSMUST00000140307.1 ENSMUST00000140307.2 ENSMUST00000140307.3 NR_040558 uc007dqr.1 uc007dqr.2 uc007dqr.3 uc007dqr.1 uc007dqr.2 uc007dqr.3 
ENSMUST00000140320.10 4930517O19Rik ENSMUST00000140320.10 4930517O19Rik (from geneSymbol) AK015818 ENSMUST00000140320.1 ENSMUST00000140320.2 ENSMUST00000140320.3 ENSMUST00000140320.4 ENSMUST00000140320.5 ENSMUST00000140320.6 ENSMUST00000140320.7 ENSMUST00000140320.8 ENSMUST00000140320.9 uc288wek.1 uc288wek.2 uc288wek.3 uc288wek.1 uc288wek.2 uc288wek.3 
ENSMUST00000140321.3 1700047F07Rik ENSMUST00000140321.3 1700047F07Rik (from geneSymbol) AK006706 ENSMUST00000140321.1 ENSMUST00000140321.2 uc008tzz.1 uc008tzz.2 uc008tzz.3 uc008tzz.1 uc008tzz.2 uc008tzz.3 
ENSMUST00000140364.8 Adck2 ENSMUST00000140364.8 aarF domain containing kinase 2 (from RefSeq NM_178873.3) A0A0R4J1X6 A0A0R4J1X6_MOUSE Adck2 ENSMUST00000140364.1 ENSMUST00000140364.2 ENSMUST00000140364.3 ENSMUST00000140364.4 ENSMUST00000140364.5 ENSMUST00000140364.6 ENSMUST00000140364.7 NM_178873 uc009bmb.1 uc009bmb.2 uc009bmb.3 Belongs to the protein kinase superfamily. ADCK protein kinase family. kinase activity phosphorylation uc009bmb.1 uc009bmb.2 uc009bmb.3 
ENSMUST00000140380.2 Gm11672 ENSMUST00000140380.2 Gm11672 (from geneSymbol) ENSMUST00000140380.1 uc288cym.1 uc288cym.2 uc288cym.1 uc288cym.2 
ENSMUST00000140402.8 Tmem44 ENSMUST00000140402.8 transmembrane protein 44, transcript variant 2 (from RefSeq NM_172614.3) E9Q4M0 E9Q4M0_MOUSE ENSMUST00000140402.1 ENSMUST00000140402.2 ENSMUST00000140402.3 ENSMUST00000140402.4 ENSMUST00000140402.5 ENSMUST00000140402.6 ENSMUST00000140402.7 NM_172614 Tmem44 uc007ywq.1 uc007ywq.2 uc007ywq.3 molecular_function cellular_component biological_process membrane integral component of membrane uc007ywq.1 uc007ywq.2 uc007ywq.3 
ENSMUST00000140438.2 Mrps25 ENSMUST00000140438.2 mitochondrial ribosomal protein S25 (from RefSeq NM_025578.4) ENSMUST00000140438.1 NM_025578 Q9CYY8 Q9D125 RT25_MOUSE Rpms25 uc009cyu.1 uc009cyu.2 uc009cyu.3 uc009cyu.4 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mS25 family. structural constituent of ribosome mitochondrion mitochondrial small ribosomal subunit ribosome mitochondrial translation uc009cyu.1 uc009cyu.2 uc009cyu.3 uc009cyu.4 
ENSMUST00000140450.2 Gm14717 ENSMUST00000140450.2 Gm14717 (from geneSymbol) ENSMUST00000140450.1 uc292pdt.1 uc292pdt.2 uc292pdt.1 uc292pdt.2 
ENSMUST00000140465.3 Gm13850 ENSMUST00000140465.3 Gm13850 (from geneSymbol) ENSMUST00000140465.1 ENSMUST00000140465.2 uc291dja.1 uc291dja.2 uc291dja.3 uc291dja.1 uc291dja.2 uc291dja.3 
ENSMUST00000140466.8 Dync2h1 ENSMUST00000140466.8 May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. According to PubMed:8666668, it may play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells. (from UniProt Q45VK7) B8JJF9 B8JJG0 DQ104402 DYHC2_MOUSE Dhc1b Dnchc2 ENSMUST00000140466.1 ENSMUST00000140466.2 ENSMUST00000140466.3 ENSMUST00000140466.4 ENSMUST00000140466.5 ENSMUST00000140466.6 ENSMUST00000140466.7 Kiaa1997 O08822 Q45VK7 Q5VI59 Q5VI60 Q5VI61 Q5VI62 Q69Z42 Q8BJL5 Q8BL87 Q8BMC7 Q8BUI9 Q8BXK5 Q9CRR8 uc292ehv.1 uc292ehv.2 May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. According to PubMed:8666668, it may play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells. The cytoplasmic dynein complex 2 is probably composed by a heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains. Cytoplasm, cytoskeleton, cilium axoneme Cell membrane ; Peripheral membrane protein Cytoplasm Note=Localizes to the apical cytoplasm (By similarity). According to PubMed:8666668, it localizes to Golgi apparatus, cytoplasmic vesicle and endoplasmic reticulum (PubMed:8666668). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q45VK7-1; Sequence=Displayed; Name=2; IsoId=Q45VK7-2; Sequence=VSP_031286; Name=3; IsoId=Q45VK7-3; Sequence=VSP_031284, VSP_031285; Detected in brain, lung, spleen and kidney (at protein level). Enriched in the ependymal layer lining the lateral ventricles (at protein level). Expressed at 9.5 and 10.5 dpc in the neural tube where it is enriched in rostral part. Mice homozygous for Dync2h1 null alleles die at approximately 12.5 dpc with abnormal brain morphology, frequent heart- looping and occasionally with polysyndactily. Cilia have abnormal morphology. Belongs to the dynein heavy chain family. Sequence=BAB29399.2; Type=Erroneous initiation; Evidence=; Sequence=BAC38914.1; Type=Erroneous initiation; Evidence=; nucleotide binding motor activity microtubule motor activity ATP binding cytoplasm Golgi apparatus cytoskeleton cytoplasmic dynein complex microtubule plasma membrane cilium axoneme microtubule-based movement Golgi organization multicellular organism development determination of left/right symmetry heart development ATP-dependent microtubule motor activity, minus-end-directed dorsal/ventral pattern formation membrane protein processing spinal cord motor neuron differentiation cell projection organization neuron differentiation dynein complex embryonic limb morphogenesis forebrain development motile cilium intraciliary retrograde transport cell projection apical part of cell dynein intermediate chain binding positive regulation of smoothened signaling pathway dynein light intermediate chain binding cilium assembly coronary vasculature development protein localization to cilium non-motile cilium assembly uc292ehv.1 uc292ehv.2 
ENSMUST00000140485.8 Raph1 ENSMUST00000140485.8 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (from RefSeq NM_001045513.3) ENSMUST00000140485.1 ENSMUST00000140485.2 ENSMUST00000140485.3 ENSMUST00000140485.4 ENSMUST00000140485.5 ENSMUST00000140485.6 ENSMUST00000140485.7 F2Z3U3 F2Z3U3_MOUSE NM_001045513 Raph1 uc007bet.1 uc007bet.2 uc007bet.3 uc007bet.4 protein binding cytosol plasma membrane signal transduction nuclear body cell leading edge axon extension uc007bet.1 uc007bet.2 uc007bet.3 uc007bet.4 
ENSMUST00000140506.2 Gm15668 ENSMUST00000140506.2 Gm15668 (from geneSymbol) BC108272 ENSMUST00000140506.1 uc287iyb.1 uc287iyb.2 uc287iyb.1 uc287iyb.2 
ENSMUST00000140523.8 Slc38a6 ENSMUST00000140523.8 solute carrier family 38, member 6 (from RefSeq NM_001037717.3) B2RXN5 ENSMUST00000140523.1 ENSMUST00000140523.2 ENSMUST00000140523.3 ENSMUST00000140523.4 ENSMUST00000140523.5 ENSMUST00000140523.6 ENSMUST00000140523.7 G3UVW3 NM_001037717 S38A6_MOUSE Slc38a6 Snat6 uc011yns.1 uc011yns.2 uc011yns.3 uc011yns.4 Amino acid transporter with an apparent selectivity for L- glutamine and L-glutamate. May facilitate glutamine uptake in excitatory neurons. The transport mechanism remains to be elucidated. Reaction=L-glutamine(out) = L-glutamine(in); Xref=Rhea:RHEA:73419, ChEBI:CHEBI:58359; Evidence=; Reaction=L-glutamate(out) = L-glutamate(in); Xref=Rhea:RHEA:66336, ChEBI:CHEBI:29985; Evidence=; Cell membrane ; Multi-pass membrane protein Synapse. Note=Colocalizes with synaptotagmins and SNAP25. Expressed exclusively in neurons and not in astrocytes and glia cells. Highly expressed in the synapse. Highly expressed in glutamatergic neurons. Primarily expressed in excitatory neurons, with some minor expression in inhibitory neurons. Belongs to the amino acid/polyamine transporter 2 family. amino acid transmembrane transport plasma membrane integral component of plasma membrane amino acid transmembrane transporter activity membrane integral component of membrane uc011yns.1 uc011yns.2 uc011yns.3 uc011yns.4 
ENSMUST00000140556.2 Adap2os ENSMUST00000140556.2 ArfGAP with dual PH domains 2, opposite strand (from RefSeq NR_188974.1) ENSMUST00000140556.1 NR_188974 uc288asd.1 uc288asd.2 uc288asd.1 uc288asd.2 
ENSMUST00000140614.2 E330016L19Rik ENSMUST00000140614.2 RIKEN cDNA E330016L19 gene (from RefSeq NR_153315.1) ENSMUST00000140614.1 NR_153315 uc009swm.1 uc009swm.2 uc009swm.3 uc009swm.1 uc009swm.2 uc009swm.3 
ENSMUST00000140639.3 Gm12911 ENSMUST00000140639.3 Gm12911 (from geneSymbol) ENSMUST00000140639.1 ENSMUST00000140639.2 uc290nfw.1 uc290nfw.2 uc290nfw.3 uc290nfw.1 uc290nfw.2 uc290nfw.3 
ENSMUST00000140646.2 Gm15513 ENSMUST00000140646.2 Gm15513 (from geneSymbol) ENSMUST00000140646.1 KY468039 uc057lly.1 uc057lly.2 uc057lly.1 uc057lly.2 
ENSMUST00000140655.2 ENSMUSG00000121882 ENSMUST00000140655.2 ENSMUSG00000121882 (from geneSymbol) BC116353 ENSMUST00000140655.1 uc292opk.1 uc292opk.2 uc292opk.1 uc292opk.2 
ENSMUST00000140669.2 Gm15356 ENSMUST00000140669.2 Gm15356 (from geneSymbol) AK138572 ENSMUST00000140669.1 uc292ahh.1 uc292ahh.2 uc292ahh.1 uc292ahh.2 
ENSMUST00000140672.3 Gm43191 ENSMUST00000140672.3 Golgi apparatus membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt F6YIH5) BC118047 ENSMUST00000140672.1 ENSMUST00000140672.2 F6YIH5 F6YIH5_MOUSE Gm43191 uc290jai.1 uc290jai.2 Golgi apparatus membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. Golgi membrane integral component of plasma membrane pyrimidine nucleotide-sugar transmembrane transporter activity membrane integral component of membrane transmembrane transporter activity transmembrane transport pyrimidine nucleotide-sugar transmembrane transport uc290jai.1 uc290jai.2 
ENSMUST00000140673.8 2610027K06Rik ENSMUST00000140673.8 RIKEN cDNA 2610027K06 gene (from RefSeq NR_077059.1) ENSMUST00000140673.1 ENSMUST00000140673.2 ENSMUST00000140673.3 ENSMUST00000140673.4 ENSMUST00000140673.5 ENSMUST00000140673.6 ENSMUST00000140673.7 NR_077059 uc288bbg.1 uc288bbg.2 uc288bbg.1 uc288bbg.2 
ENSMUST00000140689.9 1700003G18Rik ENSMUST00000140689.9 1700003G18Rik (from geneSymbol) ENSMUST00000140689.1 ENSMUST00000140689.2 ENSMUST00000140689.3 ENSMUST00000140689.4 ENSMUST00000140689.5 ENSMUST00000140689.6 ENSMUST00000140689.7 ENSMUST00000140689.8 KY468160 uc009jiv.1 uc009jiv.2 uc009jiv.3 uc009jiv.4 uc009jiv.5 uc009jiv.1 uc009jiv.2 uc009jiv.3 uc009jiv.4 uc009jiv.5 
ENSMUST00000140726.3 AI507597 ENSMUST00000140726.3 AI507597 (from geneSymbol) AK131719 ENSMUST00000140726.1 ENSMUST00000140726.2 uc008vov.1 uc008vov.2 uc008vov.3 uc008vov.4 uc008vov.1 uc008vov.2 uc008vov.3 uc008vov.4 
ENSMUST00000140736.3 Taco1os ENSMUST00000140736.3 Taco1os (from geneSymbol) AK019365 ENSMUST00000140736.1 ENSMUST00000140736.2 uc007lya.1 uc007lya.2 uc007lya.3 uc007lya.4 uc007lya.1 uc007lya.2 uc007lya.3 uc007lya.4 
ENSMUST00000140754.2 Gm2018 ENSMUST00000140754.2 Gm2018 (from geneSymbol) ENSMUST00000140754.1 uc288bic.1 uc288bic.2 uc288bic.1 uc288bic.2 
ENSMUST00000140761.9 Ppm1m ENSMUST00000140761.9 protein phosphatase 1M, transcript variant 1 (from RefSeq NM_026447.4) A0A8I4Q8Y8 A0A8I4Q8Y8_MOUSE ENSMUST00000140761.1 ENSMUST00000140761.2 ENSMUST00000140761.3 ENSMUST00000140761.4 ENSMUST00000140761.5 ENSMUST00000140761.6 ENSMUST00000140761.7 ENSMUST00000140761.8 NM_026447 Ppm1m uc012gzs.1 uc012gzs.2 uc012gzs.3 uc012gzs.1 uc012gzs.2 uc012gzs.3 
ENSMUST00000140770.2 Plekhd1 ENSMUST00000140770.2 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 (from RefSeq NM_001177503.1) B2RPU2 ENSMUST00000140770.1 NM_001177503 PLHD1_MOUSE uc007obf.1 uc007obf.2 uc007obf.3 uc007obf.4 Belongs to the PLEKHD1 family. molecular_function cellular_component biological_process uc007obf.1 uc007obf.2 uc007obf.3 uc007obf.4 
ENSMUST00000140815.3 4933411O13Rik ENSMUST00000140815.3 4933411O13Rik (from geneSymbol) AK029643 ENSMUST00000140815.1 ENSMUST00000140815.2 uc289fju.1 uc289fju.2 uc289fju.3 uc289fju.1 uc289fju.2 uc289fju.3 
ENSMUST00000140826.2 Gm12462 ENSMUST00000140826.2 Gm12462 (from geneSymbol) AK029677 ENSMUST00000140826.1 uc290mkc.1 uc290mkc.2 uc290mkc.1 uc290mkc.2 
ENSMUST00000140833.4 Gm15728 ENSMUST00000140833.4 predicted gene 15728 (from RefSeq NR_166496.1) ENSMUST00000140833.1 ENSMUST00000140833.2 ENSMUST00000140833.3 NR_166496 uc290yyr.1 uc290yyr.2 uc290yyr.3 uc290yyr.4 uc290yyr.1 uc290yyr.2 uc290yyr.3 uc290yyr.4 
ENSMUST00000140840.8 Marchf11 ENSMUST00000140840.8 membrane associated ring-CH-type finger 11, transcript variant 1 (from RefSeq NM_177597.6) B9EIG0 ENSMUST00000140840.1 ENSMUST00000140840.2 ENSMUST00000140840.3 ENSMUST00000140840.4 ENSMUST00000140840.5 ENSMUST00000140840.6 ENSMUST00000140840.7 MARHB_MOUSE March11 NM_177597 Q8CBH7 uc011zrq.1 uc011zrq.2 uc011zrq.3 uc011zrq.4 uc011zrq.5 E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts (YXXL motif) with AP1M1. Interacts (via PDZ-binding motif) with LIN7A. Interacts with unidentified fucose glycoproteins. Cytoplasmic vesicle membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CBH7-1; Sequence=Displayed; Name=2; IsoId=Q8CBH7-2; Sequence=VSP_034148, VSP_034149; The RING-CH-type zinc finger domain is required for E3 ligase activity. molecular_function cellular_component biological_process zinc ion binding membrane integral component of membrane protein ubiquitination transferase activity cytoplasmic vesicle membrane cytoplasmic vesicle metal ion binding uc011zrq.1 uc011zrq.2 uc011zrq.3 uc011zrq.4 uc011zrq.5 
ENSMUST00000140890.3 Gm49987 ENSMUST00000140890.3 Gm49987 (from geneSymbol) BC091770 ENSMUST00000140890.1 ENSMUST00000140890.2 uc289gwj.1 uc289gwj.2 uc289gwj.1 uc289gwj.2 
ENSMUST00000140901.8 Fzr1 ENSMUST00000140901.8 fizzy and cell division cycle 20 related 1 (from RefSeq NM_019757.1) ENSMUST00000140901.1 ENSMUST00000140901.2 ENSMUST00000140901.3 ENSMUST00000140901.4 ENSMUST00000140901.5 ENSMUST00000140901.6 ENSMUST00000140901.7 FZR1_MOUSE Fyr Fzr NM_019757 Q9R1K5 uc007ght.1 uc007ght.2 uc007ght.3 Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). Protein modification; protein ubiquitination. The unphosphorylated form interacts with APC/C during mitosis. Interacts with NINL. Interacts (in complex with the anaphase promoting complex APC) with MAD2L2; inhibits FZR1-mediated APC/C activation (By similarity). Interacts with SIRT2 (PubMed:22014574). Interacts with USP37. Interacts (via WD repeats) with MAK. Interacts with RBBP8/CtIP; this interaction leads to RBBP8 proteasomal degradation. Interacts with HECW2 (By similarity). Interacts with SASS6; the interaction is regulated by CENATAC and leads to SASS6 proteasomal degradation (By similarity). Interacts (via N-terminus) with CCNF (By similarity). Interacts with CDC6 (By similarity). Interacts with TK1 (via the KEN box) (By similarity). Q9R1K5; Q8VDQ8: Sirt2; NbExp=2; IntAct=EBI-5238560, EBI-911012; Acetylated. Deacetylated by SIRT2 at Lys-69 and Lys-159; deacetylation enhances the interaction of FZR1 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C). Following DNA damage, it is dephosphorylated by CDC14B in G2 phase, leading to its reassociation with the APC/C, and allowing an efficient G2 DNA damage checkpoint (By similarity). Phosphorylated by MAK (By similarity). Belongs to the WD repeat CDC20/Fizzy family. protein binding nucleoplasm anaphase-promoting complex DNA repair cellular response to DNA damage stimulus cell cycle positive regulation of cell proliferation anaphase-promoting complex binding protein ubiquitination anaphase-promoting complex-dependent catabolic process nuclear membrane regulation of meiotic nuclear division positive regulation of protein catabolic process cell division lens fiber cell differentiation signal transduction involved in G2 DNA damage checkpoint negative regulation of cell aging ubiquitin-protein transferase activator activity positive regulation of ubiquitin protein ligase activity uc007ght.1 uc007ght.2 uc007ght.3 
ENSMUST00000140919.2 8030443G20Rik ENSMUST00000140919.2 RIKEN cDNA 8030443G20 gene (from RefSeq NR_040664.1) ENSMUST00000140919.1 NR_040664 uc029uyp.1 uc029uyp.2 uc029uyp.1 uc029uyp.2 
ENSMUST00000140920.2 Urb1 ENSMUST00000140920.2 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) (from RefSeq NM_029497.1) E9PU96 E9PU96_MOUSE ENSMUST00000140920.1 NM_029497 Urb1 uc007zwm.1 uc007zwm.2 uc007zwm.3 uc007zwm.4 fibrillar center nucleolus uc007zwm.1 uc007zwm.2 uc007zwm.3 uc007zwm.4 
ENSMUST00000140949.3 Gm14210 ENSMUST00000140949.3 predicted gene 14210 (from RefSeq NR_166432.1) ENSMUST00000140949.1 ENSMUST00000140949.2 NR_166432 uc290auq.1 uc290auq.2 uc290auq.3 uc290auq.1 uc290auq.2 uc290auq.3 
ENSMUST00000140958.2 Gm15507 ENSMUST00000140958.2 Gm15507 (from geneSymbol) AK045788 ENSMUST00000140958.1 uc292hwk.1 uc292hwk.2 uc292hwk.1 uc292hwk.2 
ENSMUST00000140975.8 Cenpo ENSMUST00000140975.8 centromere protein O, transcript variant 1 (from RefSeq NM_134046.6) CENPO_MOUSE ENSMUST00000140975.1 ENSMUST00000140975.2 ENSMUST00000140975.3 ENSMUST00000140975.4 ENSMUST00000140975.5 ENSMUST00000140975.6 ENSMUST00000140975.7 Mcm21r NM_134046 Q8K015 Q8R587 Q9CYY6 uc007mxn.1 uc007mxn.2 uc007mxn.3 Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex (By similarity). Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity). Nucleus Chromosome, centromere Chromosome, centromere, kinetochore Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K015-1; Sequence=Displayed; Name=2; IsoId=Q8K015-2; Sequence=VSP_020447, VSP_020448; Belongs to the CENP-O/MCM21 family. chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed nuclear chromosome kinetochore nucleus chromosome biological_process Mis6-Sim4 complex centromere complex assembly uc007mxn.1 uc007mxn.2 uc007mxn.3 
ENSMUST00000140978.2 Gm13631 ENSMUST00000140978.2 Gm13631 (from geneSymbol) AK141988 ENSMUST00000140978.1 uc289wsm.1 uc289wsm.2 uc289wsm.1 uc289wsm.2 
ENSMUST00000140991.2 Sap30bp ENSMUST00000140991.2 SAP30 binding protein, transcript variant 5 (from RefSeq NR_184578.1) ENSMUST00000140991.1 Hcngp NR_184578 Q02614 Q8VDJ5 S30BP_MOUSE uc007mjd.1 uc007mjd.2 uc007mjd.3 Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (By similarity). May be involved in the regulation of beta-2- microglobulin genes (PubMed:1459361). Interacts with histone deacetylase complex subunit SAP30. Nucleus Belongs to the HCNGP family. nucleus nucleoplasm regulation of transcription, DNA-templated apoptotic process positive regulation of cell death intermediate filament cytoskeleton uc007mjd.1 uc007mjd.2 uc007mjd.3 
ENSMUST00000141023.3 Gm13609 ENSMUST00000141023.3 Gm13609 (from geneSymbol) ENSMUST00000141023.1 ENSMUST00000141023.2 uc289uza.1 uc289uza.2 uc289uza.3 uc289uza.1 uc289uza.2 uc289uza.3 
ENSMUST00000141035.2 Gm14471 ENSMUST00000141035.2 Gm14471 (from geneSymbol) AK076552 ENSMUST00000141035.1 uc289urx.1 uc289urx.2 uc289urx.1 uc289urx.2 
ENSMUST00000141047.2 Gm21985 ENSMUST00000141047.2 Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out); Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103; Evidence=; (from UniProt Q6P6P5) BC062099 ENSMUST00000141047.1 Gm21985 Q6P6P5 Q6P6P5_MOUSE Slc12a6 uc289zhl.1 uc289zhl.2 Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out); Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the SLC12A transporter family. integral component of plasma membrane ion transport cell volume homeostasis chemical synaptic transmission cation:chloride symporter activity potassium:chloride symporter activity membrane integral component of membrane transmembrane transporter activity chloride ion homeostasis potassium ion homeostasis transmembrane transport cellular hypotonic salinity response chloride transmembrane transport potassium ion import across plasma membrane uc289zhl.1 uc289zhl.2 
ENSMUST00000141051.8 Ppp4r1l-ps ENSMUST00000141051.8 protein phosphatase 4, regulatory subunit 1-like, pseudogene (from RefSeq NR_027957.1) ENSMUST00000141051.1 ENSMUST00000141051.2 ENSMUST00000141051.3 ENSMUST00000141051.4 ENSMUST00000141051.5 ENSMUST00000141051.6 ENSMUST00000141051.7 NR_027957 uc008odx.1 uc008odx.2 uc008odx.3 uc008odx.1 uc008odx.2 uc008odx.3 
ENSMUST00000141091.3 ENSMUSG00000121733 ENSMUST00000141091.3 ENSMUSG00000121733 (from geneSymbol) AK133155 ENSMUST00000141091.1 ENSMUST00000141091.2 uc291dkz.1 uc291dkz.2 uc291dkz.3 uc291dkz.1 uc291dkz.2 uc291dkz.3 
ENSMUST00000141112.2 AU022252 ENSMUST00000141112.2 expressed sequence AU022252, transcript variant 2 (from RefSeq NM_001425763.1) CA050_MOUSE ENSMUST00000141112.1 NM_001425763 Q5EBG8 uc008ulo.1 uc008ulo.2 uc008ulo.3 uc008ulo.4 cellular_component biological_process identical protein binding uc008ulo.1 uc008ulo.2 uc008ulo.3 uc008ulo.4 
ENSMUST00000141116.2 Taf10 ENSMUST00000141116.2 TATA-box binding protein associated factor 10, transcript variant 1 (from RefSeq NM_020024.4) ENSMUST00000141116.1 NM_020024 Q8C8H2 Q8K0H5 Q9QYY5 TAF10_MOUSE Taf2h Tafii30 uc009izf.1 uc009izf.2 uc009izf.3 The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF10 is also component of the PCAF histone acetylase complex, the TATA-binding protein-free TAF complex (TFTC) and the STAGA transcription coactivator-HAT complex (By similarity). May regulate cyclin E expression (PubMed:10469660). Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP- associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. The PCAF complex consists at least of TADA2L/ADA2, TADA3L/ADA3, SUPT3H, TAF5L TAF6L, TAF9, TAF10, TAF12 and TRRAP. The TFTC-HAT complex consists at least of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. The STAGA transcription coactivator-HAT complex consists at least of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Interacts with LOXL2. Interacts with TAF12 isoform TAFII20; the interaction is direct (By similarity). Interacts with TAF3 (PubMed:11438666). Nucleus The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase. Monomethylated at Lys-189 by SETD7, leading to increased affinity for RNA polymerase II. Lysine deamination at Lys-189 to form allysine is mediated by LOXL2. Allysine formation by LOXL2 results in release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. Belongs to the TAF10 family. G1/S transition of mitotic cell cycle PCAF complex liver development DNA binding histone acetyltransferase activity nucleus nucleoplasm transcription factor TFIID complex cytoplasm DNA-templated transcription, initiation regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter apoptotic process regulation of gene expression obsolete general RNA polymerase II transcription factor activity histone deubiquitination enzyme binding estrogen receptor binding STAGA complex transcription factor TFTC complex cellular macromolecular complex assembly multicellular organism growth histone H3 acetylation perinuclear region of cytoplasm regulation of DNA binding protein homooligomerization RNA polymerase binding hepatocyte differentiation uc009izf.1 uc009izf.2 uc009izf.3 
ENSMUST00000141118.9 Alas1 ENSMUST00000141118.9 aminolevulinic acid synthase 1, transcript variant 2 (from RefSeq NM_020559.2) ENSMUST00000141118.1 ENSMUST00000141118.2 ENSMUST00000141118.3 ENSMUST00000141118.4 ENSMUST00000141118.5 ENSMUST00000141118.6 ENSMUST00000141118.7 ENSMUST00000141118.8 HEM1_MOUSE NM_020559 Q64453 Q8VC19 uc012gzt.1 uc012gzt.2 uc012gzt.3 Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Reaction=glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO2 + CoA; Xref=Rhea:RHEA:12921, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:57305, ChEBI:CHEBI:356416; EC=2.3.1.37; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12922; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1. Homodimer (By similarity). Interacts (hydroxylated form) with VHL (By similarity). Mitochondrion inner membrane ; Peripheral membrane protein Note=Localizes to the matrix side of the mitochondrion inner membrane. In normoxia, is hydroxylated at Pro-578, promoting interaction with VHL, initiating ubiquitination and subsequent degradation via the proteasome. Ubiquitinated; in normoxia following hydroxylation and interaction with VHL, leading to its subsequent degradation via the proteasome. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. catalytic activity 5-aminolevulinate synthase activity nucleoplasm mitochondrion mitochondrial matrix cytosol porphyrin-containing compound metabolic process protoporphyrinogen IX biosynthetic process heme biosynthetic process biosynthetic process transferase activity transferase activity, transferring acyl groups pyridoxal phosphate binding tetrapyrrole biosynthetic process identical protein binding uc012gzt.1 uc012gzt.2 uc012gzt.3 
ENSMUST00000141133.2 Gm13496 ENSMUST00000141133.2 Gm13496 (from geneSymbol) ENSMUST00000141133.1 uc289vud.1 uc289vud.2 uc289vud.1 uc289vud.2 
ENSMUST00000141162.2 Gm11217 ENSMUST00000141162.2 predicted gene 11217 (from RefSeq NR_151546.1) ENSMUST00000141162.1 NR_151546 uc008thl.1 uc008thl.2 uc008thl.1 uc008thl.2 
ENSMUST00000141168.2 Gm16156 ENSMUST00000141168.2 Gm16156 (from geneSymbol) ENSMUST00000141168.1 uc292cxn.1 uc292cxn.2 uc292cxn.1 uc292cxn.2 
ENSMUST00000141174.2 Gm14493 ENSMUST00000141174.2 Gm14493 (from geneSymbol) ENSMUST00000141174.1 uc292nfp.1 uc292nfp.2 uc292nfp.1 uc292nfp.2 
ENSMUST00000141199.8 Gm16325 ENSMUST00000141199.8 predicted gene 16325 (from RefSeq NR_045949.1) ENSMUST00000141199.1 ENSMUST00000141199.2 ENSMUST00000141199.3 ENSMUST00000141199.4 ENSMUST00000141199.5 ENSMUST00000141199.6 ENSMUST00000141199.7 NR_045949 uc029upa.1 uc029upa.2 uc029upa.1 uc029upa.2 
ENSMUST00000141216.3 Gm15747 ENSMUST00000141216.3 Gm15747 (from geneSymbol) AK040553 ENSMUST00000141216.1 ENSMUST00000141216.2 uc008znp.1 uc008znp.2 uc008znp.3 uc008znp.4 uc008znp.1 uc008znp.2 uc008znp.3 uc008znp.4 
ENSMUST00000141235.8 Zbtb8os ENSMUST00000141235.8 zinc finger and BTB domain containing 8 opposite strand (from RefSeq NM_025970.4) B2KGA7 B2KGA7_MOUSE ENSMUST00000141235.1 ENSMUST00000141235.2 ENSMUST00000141235.3 ENSMUST00000141235.4 ENSMUST00000141235.5 ENSMUST00000141235.6 ENSMUST00000141235.7 NM_025970 Zbtb8os uc008uwu.1 uc008uwu.2 uc008uwu.3 Component of the tRNA-splicing ligase complex. Belongs to the archease family. uc008uwu.1 uc008uwu.2 uc008uwu.3 
ENSMUST00000141242.3 Gm12958 ENSMUST00000141242.3 Gm12958 (from geneSymbol) ENSMUST00000141242.1 ENSMUST00000141242.2 uc290pzm.1 uc290pzm.2 uc290pzm.3 uc290pzm.1 uc290pzm.2 uc290pzm.3 
ENSMUST00000141256.3 Tnk2os ENSMUST00000141256.3 tyrosine kinase, non-receptor 2, opposite strand (from RefSeq NR_033493.1) ENSMUST00000141256.1 ENSMUST00000141256.2 NR_033493 uc012aep.1 uc012aep.2 uc012aep.3 uc012aep.1 uc012aep.2 uc012aep.3 
ENSMUST00000141299.3 Gm15579 ENSMUST00000141299.3 Gm15579 (from geneSymbol) ENSMUST00000141299.1 ENSMUST00000141299.2 uc291xnm.1 uc291xnm.2 uc291xnm.3 uc291xnm.1 uc291xnm.2 uc291xnm.3 
ENSMUST00000141300.2 Hottip ENSMUST00000141300.2 Hoxa distal transcript antisense RNA, transcript variant 1 (from RefSeq NR_110441.1) ENSMUST00000141300.1 NR_110441 uc009byt.1 uc009byt.2 uc009byt.3 uc009byt.4 uc009byt.1 uc009byt.2 uc009byt.3 uc009byt.4 
ENSMUST00000141307.4 Gm15543 ENSMUST00000141307.4 predicted gene 15543 (from RefSeq NR_157240.1) ENSMUST00000141307.1 ENSMUST00000141307.2 ENSMUST00000141307.3 NR_157240 uc009erd.1 uc009erd.2 uc009erd.3 uc009erd.4 uc009erd.5 uc009erd.1 uc009erd.2 uc009erd.3 uc009erd.4 uc009erd.5 
ENSMUST00000141329.10 Hnf4aos ENSMUST00000141329.10 hepatic nuclear factor 4 alpha, opposite strand (from RefSeq NR_027970.1) ENSMUST00000141329.1 ENSMUST00000141329.2 ENSMUST00000141329.3 ENSMUST00000141329.4 ENSMUST00000141329.5 ENSMUST00000141329.6 ENSMUST00000141329.7 ENSMUST00000141329.8 ENSMUST00000141329.9 NR_027970 uc008nsx.1 uc008nsx.2 uc008nsx.3 uc008nsx.4 uc008nsx.5 uc008nsx.6 uc008nsx.1 uc008nsx.2 uc008nsx.3 uc008nsx.4 uc008nsx.5 uc008nsx.6 
ENSMUST00000141341.2 Gm13814 ENSMUST00000141341.2 Gm13814 (from geneSymbol) AK036400 ENSMUST00000141341.1 uc289yok.1 uc289yok.2 uc289yok.1 uc289yok.2 
ENSMUST00000141344.3 D430001F17Rik ENSMUST00000141344.3 D430001F17Rik (from geneSymbol) AK052392 ENSMUST00000141344.1 ENSMUST00000141344.2 uc289gdv.1 uc289gdv.2 uc289gdv.1 uc289gdv.2 
ENSMUST00000141380.3 Meiosin ENSMUST00000141380.3 meiosis initiator, transcript variant 2 (from RefSeq NM_001370812.1) A0A5K7RLP0 Bhmg1 D3YZT1 ENSMUST00000141380.1 ENSMUST00000141380.2 MEIOS_MOUSE Meiosin NM_001370812 uc291mhw.1 uc291mhw.2 Gatekeeper of meiotic initiation in both male and female germ cells (PubMed:32032549). In complex with STRA8, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. Temporal expression of MEIOSIN is required for meiotic entry decision (PubMed:32032549). Interacts with STRA8. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A0A5K7RLP0-1; Sequence=Displayed; Name=2; IsoId=A0A5K7RLP0-2; Sequence=VSP_060768; Specifically expressed in adult testis and embryonic ovary. Induced in 13.5 dpc in the embryonic ovary, expression persists at least until 18.5 dpc (PubMed:32032549). In testes, expressed in spermatocytes during the preleptotene stage in the stage VII-VIII seminiferous tubules (at protein level) (PubMed:32032549). Mutant mice develop normally. Males show defects in reproductive organs with smaller-than-normal testes (PubMed:32032549). They have severely impaired spermatogenesis and the absence of postmeiotic spermatids or sperm in testes and epididymis (PubMed:32032549). Female ovaries are degenerated with apparently fewer mature follicles at the age of 4 weeks old (PubMed:32032549). uc291mhw.1 uc291mhw.2 
ENSMUST00000141387.4 Sypl2 ENSMUST00000141387.4 synaptophysin like 2 (from RefSeq NM_008596.1) ENSMUST00000141387.1 ENSMUST00000141387.2 ENSMUST00000141387.3 Mg29 NM_008596 O89104 SYPL2_MOUSE uc008qyn.1 uc008qyn.2 uc008qyn.3 Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes. Membrane; Multi-pass membrane protein. Note=Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum. Expressed abundantly in skeletal muscle and at lower levels in the kidney. Belongs to the synaptophysin/synaptobrevin family. cellular calcium ion homeostasis heart development synaptic vesicle membrane integral component of membrane syntaxin-1 binding synaptic vesicle membrane T-tubule organization uc008qyn.1 uc008qyn.2 uc008qyn.3 
ENSMUST00000141428.8 8030451A03Rik ENSMUST00000141428.8 RIKEN cDNA 8030451A03 gene, transcript variant 1 (from RefSeq NR_190130.1) ENSMUST00000141428.1 ENSMUST00000141428.2 ENSMUST00000141428.3 ENSMUST00000141428.4 ENSMUST00000141428.5 ENSMUST00000141428.6 ENSMUST00000141428.7 NR_190130 uc008thj.1 uc008thj.2 uc008thj.1 uc008thj.2 
ENSMUST00000141429.8 Cep128 ENSMUST00000141429.8 centrosomal protein 128 (from RefSeq NM_181815.3) CE128_MOUSE ENSMUST00000141429.1 ENSMUST00000141429.2 ENSMUST00000141429.3 ENSMUST00000141429.4 ENSMUST00000141429.5 ENSMUST00000141429.6 ENSMUST00000141429.7 NM_181815 Q8BI22 uc007okl.1 uc007okl.2 uc007okl.3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle pole Note=Associates with the mother centriole. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BI22-1; Sequence=Displayed; Name=2; IsoId=Q8BI22-2; Sequence=VSP_030197, VSP_030198; Sequence=BAC26523.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; spindle pole molecular_function cytoplasm centriole cytoskeleton protein localization uc007okl.1 uc007okl.2 uc007okl.3 
ENSMUST00000141440.3 Gm15687 ENSMUST00000141440.3 Gm15687 (from geneSymbol) AK082669 ENSMUST00000141440.1 ENSMUST00000141440.2 uc291kdp.1 uc291kdp.2 uc291kdp.3 uc291kdp.1 uc291kdp.2 uc291kdp.3 
ENSMUST00000141452.2 C630028M04Rik ENSMUST00000141452.2 RIKEN cDNA C630028M04 gene (from RefSeq NR_040668.1) ENSMUST00000141452.1 NR_040668 uc029uug.1 uc029uug.2 uc029uug.1 uc029uug.2 
ENSMUST00000141455.2 Gm16093 ENSMUST00000141455.2 Gm16093 (from geneSymbol) ENSMUST00000141455.1 uc290dzv.1 uc290dzv.2 uc290dzv.1 uc290dzv.2 
ENSMUST00000141469.2 Gm13025 ENSMUST00000141469.2 Gm13025 (from geneSymbol) AK043690 ENSMUST00000141469.1 uc008vmz.1 uc008vmz.2 uc008vmz.1 uc008vmz.2 
ENSMUST00000141511.3 Gm13999 ENSMUST00000141511.3 Gm13999 (from geneSymbol) AK016792 ENSMUST00000141511.1 ENSMUST00000141511.2 uc289zqw.1 uc289zqw.2 uc289zqw.3 uc289zqw.1 uc289zqw.2 uc289zqw.3 
ENSMUST00000141538.2 Gm11831 ENSMUST00000141538.2 Gm11831 (from geneSymbol) ENSMUST00000141538.1 uc290lfb.1 uc290lfb.2 uc290lfb.1 uc290lfb.2 
ENSMUST00000141541.2 Gm15503 ENSMUST00000141541.2 Gm15503 (from geneSymbol) ENSMUST00000141541.1 KY468165 uc057lvh.1 uc057lvh.2 uc057lvh.1 uc057lvh.2 
ENSMUST00000141554.2 1700012C08Rik ENSMUST00000141554.2 1700012C08Rik (from geneSymbol) AK005894 ENSMUST00000141554.1 uc290pde.1 uc290pde.2 uc290pde.1 uc290pde.2 
ENSMUST00000141557.8 Trappc13 ENSMUST00000141557.8 trafficking protein particle complex 13, transcript variant 2 (from RefSeq NM_001093759.1) ENSMUST00000141557.1 ENSMUST00000141557.2 ENSMUST00000141557.3 ENSMUST00000141557.4 ENSMUST00000141557.5 ENSMUST00000141557.6 ENSMUST00000141557.7 NM_001093759 Q3TIR1 Q3TQS3 Q3UE00 Q8BN93 Q8VDJ6 Q9CWW3 Q9CXV2 TPC13_MOUSE uc007rst.1 uc007rst.2 uc007rst.3 Part of the multisubunit TRAPP (transport protein particle) complex. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TIR1-1; Sequence=Displayed; Name=2; IsoId=Q3TIR1-2; Sequence=VSP_031800; Name=3; IsoId=Q3TIR1-3; Sequence=VSP_031799, VSP_031800; Belongs to the TRAPPC13 family. Sequence=BAB26869.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB29083.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC39168.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function uc007rst.1 uc007rst.2 uc007rst.3 
ENSMUST00000141571.2 Gm11861 ENSMUST00000141571.2 Gm11861 (from geneSymbol) ENSMUST00000141571.1 uc290lii.1 uc290lii.2 uc290lii.1 uc290lii.2 
ENSMUST00000141593.2 4930527B05Rik ENSMUST00000141593.2 4930527B05Rik (from geneSymbol) AK132942 ENSMUST00000141593.1 uc288atl.1 uc288atl.2 uc288atl.1 uc288atl.2 
ENSMUST00000141601.9 Cnpy1 ENSMUST00000141601.9 Belongs to the canopy family. (from UniProt A0A1C7CYV1) A0A1C7CYV1 A0A1C7CYV1_MOUSE BC096464 Cnpy1 ENSMUST00000141601.1 ENSMUST00000141601.2 ENSMUST00000141601.3 ENSMUST00000141601.4 ENSMUST00000141601.5 ENSMUST00000141601.6 ENSMUST00000141601.7 ENSMUST00000141601.8 uc008wtw.1 uc008wtw.2 uc008wtw.3 uc008wtw.4 Belongs to the canopy family. uc008wtw.1 uc008wtw.2 uc008wtw.3 uc008wtw.4 
ENSMUST00000141649.2 Gm13211 ENSMUST00000141649.2 Gm13211 (from geneSymbol) AK139593 ENSMUST00000141649.1 uc289swa.1 uc289swa.2 uc289swa.1 uc289swa.2 
ENSMUST00000141652.2 Gm15472 ENSMUST00000141652.2 Gm15472 (from geneSymbol) ENSMUST00000141652.1 uc290ihi.1 uc290ihi.2 uc290ihi.1 uc290ihi.2 
ENSMUST00000141662.8 Atat1 ENSMUST00000141662.8 alpha tubulin acetyltransferase 1, transcript variant 2 (from RefSeq NM_001142745.1) ATAT_MOUSE Atat1 B8JJ75 B8JJ77 ENSMUST00000141662.1 ENSMUST00000141662.2 ENSMUST00000141662.3 ENSMUST00000141662.4 ENSMUST00000141662.5 ENSMUST00000141662.6 ENSMUST00000141662.7 Mec17 NM_001142745 Q3UZR9 Q8BM67 Q8C1D1 Q8K2M7 Q8K341 uc008cje.1 uc008cje.2 uc008cje.3 uc008cje.4 uc008cje.5 uc008cje.6 Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. Reaction=acetyl-CoA + L-lysyl-[alpha-tubulin] = CoA + H(+) + N(6)- acetyl-L-lysyl-[alpha-tubulin]; Xref=Rhea:RHEA:15277, Rhea:RHEA- COMP:11278, Rhea:RHEA-COMP:11279, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.108; Evidence= Component of the BBSome complex (By similarity). Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma- adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation. Cytoplasm mbrane, clathrin-coated pit Cell junction, focal adhesion Cell projection, axon Cytoplasm, cytoskeleton toplasm, cytoskeleton, spindle Note=In primary root dorsal ganglion neurons, localizes with acetylated tubulin in axons. Recruited to the mitotic spindle during cell division. Event=Alternative splicing; Named isoforms=5; Name=1 ; IsoId=Q8K341-1; Sequence=Displayed; Name=2 ; IsoId=Q8K341-2; Sequence=VSP_052905; Name=3 ; IsoId=Q8K341-3; Sequence=VSP_052908, VSP_052909; Name=4 ; IsoId=Q8K341-4; Sequence=VSP_052906, VSP_052907; Name=5 ; IsoId=Q8K341-5; Sequence=VSP_052905, VSP_052906, VSP_052907; Widely expressed with highest levels in neuronal tissues. In the brain, expressed in the cortex, cerebellum and hippocampus, including the pyramidal layers in CA1 and CA3, as well as the granular cell layers in the lateral blade (suprapyramidal portion) and the medial blade (infrapyramidal portion) of the dentate gyrus. In testis, mainly expressed in the internal cell layers of seminiferous tubules, where spermatocytes and spermatids are located. Widely expressed in embryos during development with particularly high expression in the spinal cord at 13.5 dpc. Autoacetylation strongly increases tubulin acetylation. Mutant mice are viable and show no overt phenotype. Drastic loss of tubulin acetylation in all tissues anlyzed, including in early embryos. In dorsal hippocampus, but not in ventral hippocampus, the dentate gyrus is slightly deformed, showing a prominent bulge in the lateral blade of the granular cell layers. In addition, the lateral ventricle appears to be dilated (PubMed:23720746). Homozygous mutant males exhibit decreased fertility (PubMed:23748901). Mature spermatozoa from cauda epididymis often show the presence of a cytoplasmic droplet attached to the annulus of the tail, indicative of impaired maturation. The flagella length is also significantly decreased in spermatozoa, especially in those cells with a cytoplasmic droplet. Spermatozoa display significantly lower motility than control sperm. However, sperm flagella display the characteristic 9 + 2 organization of axoneme microtubules (PubMed:23748901). Belongs to the acetyltransferase ATAT1 family. lysine N-acetyltransferase activity, acting on acetyl phosphate as donor cytoplasm Golgi apparatus spindle cytosol cytoskeleton microtubule clathrin-coated pit focal adhesion spermatogenesis membrane transferase activity transferase activity, transferring acyl groups tubulin N-acetyltransferase activity dentate gyrus development cell junction axon cell projection regulation of fat cell differentiation neuron development coenzyme binding regulation of microtubule cytoskeleton organization alpha-tubulin acetylation mitotic spindle microtubule bundle positive regulation of NLRP3 inflammasome complex assembly uc008cje.1 uc008cje.2 uc008cje.3 uc008cje.4 uc008cje.5 uc008cje.6 
ENSMUST00000141681.2 Igf2os ENSMUST00000141681.2 insulin-like growth factor 2, opposite strand (from RefSeq NR_002855.3) ENSMUST00000141681.1 NR_002855 uc009koe.1 uc009koe.2 This is an imprinted and paternally expressed gene transcribed in antisense to Igf2 (insulin-like growth factor 2). This gene is currently represented as producing a non-coding RNA; however, transcripts were observed to localize in the cytoplasm to polysomes, suggesting that translation may occur. [provided by RefSeq, Sep 2016]. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. ##Evidence-Data-START## Transcript exon combination :: HG975404.1, AB030734.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 9356480 ##RefSeq-Attributes-END## uc009koe.1 uc009koe.2 
ENSMUST00000141697.2 Gm14582 ENSMUST00000141697.2 Gm14582 (from geneSymbol) AK135961 ENSMUST00000141697.1 uc292odg.1 uc292odg.2 uc292odg.1 uc292odg.2 
ENSMUST00000141722.8 Stxbp5 ENSMUST00000141722.8 syntaxin binding protein 5 (tomosyn), transcript variant 3 (from RefSeq NM_001408064.1) D3Z079 D3Z079_MOUSE ENSMUST00000141722.1 ENSMUST00000141722.2 ENSMUST00000141722.3 ENSMUST00000141722.4 ENSMUST00000141722.5 ENSMUST00000141722.6 ENSMUST00000141722.7 NM_001408064 Stxbp5 uc007eiz.1 uc007eiz.2 uc007eiz.3 uc007eiz.4 Cell membrane ; Peripheral membrane protein Cytoplasm Membrane ; Peripheral membrane protein Belongs to the WD repeat L(2)GL family. cytosol synaptic vesicle integral component of membrane vesicle-mediated transport syntaxin-1 binding neuromuscular junction extrinsic component of presynaptic membrane synaptic vesicle cycle presynaptic cytosol uc007eiz.1 uc007eiz.2 uc007eiz.3 uc007eiz.4 
ENSMUST00000141741.4 Gm16933 ENSMUST00000141741.4 Gm16933 (from geneSymbol) AK041498 ENSMUST00000141741.1 ENSMUST00000141741.2 ENSMUST00000141741.3 uc291yvc.1 uc291yvc.2 uc291yvc.1 uc291yvc.2 
ENSMUST00000141752.2 Gm15521 ENSMUST00000141752.2 Gm15521 (from geneSymbol) ENSMUST00000141752.1 uc292fkw.1 uc292fkw.2 uc292fkw.1 uc292fkw.2 
ENSMUST00000141755.8 Mettl16 ENSMUST00000141755.8 methyltransferase 16, N6-methyladenosine (from RefSeq NM_026197.3) ENSMUST00000141755.1 ENSMUST00000141755.2 ENSMUST00000141755.3 ENSMUST00000141755.4 ENSMUST00000141755.5 ENSMUST00000141755.6 ENSMUST00000141755.7 MET16_MOUSE Mett10d Mettl16 NM_026197 Q3UMA9 Q9CQG2 Q9D062 uc007kch.1 uc007kch.2 uc007kch.3 RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:29262316, PubMed:30197299). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (By similarity). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (By similarity). Plays a key role in S- adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S- adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (By similarity). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:29262316). In addition to mRNAs, also able to mediate N6- methylation of U6 small nuclear RNA (U6 snRNA): specifically N6- methylates adenine in position 43 of U6 snRNAs (By similarity). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (By similarity). Specifically binds the 3'-end of the MALAT1 long non- coding RNA (By similarity) (PubMed:29262316, PubMed:30197299). Reaction=adenosine in U6 snRNA + S-adenosyl-L-methionine = H(+) + N(6)- methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:52808, Rhea:RHEA-COMP:13573, Rhea:RHEA-COMP:13574, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.346; Evidence=; Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)- methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348; Evidence=; Methyltransferase activity is autoinhibited by the K-loop region that blocks S-adenosyl-L-methionine-binding. Upon activation, K-loop changes conformation, allowing S-adenosyl-L- methionine-binding and subsequent methyltransferase activity. mRNA N6- adenosine-methyltransferase activity is inhibited by zinc. Interacts with MEPCE. Interacts with LARP7. Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQG2-1; Sequence=Displayed; Name=2; IsoId=Q9CQG2-2; Sequence=VSP_029342; The VCR (vertebrate conserved) regions bind the first hairpin of MAT2A mRNAs. The VCR regions interact with the internal stem-loop within U6 snRNAs, inducing the conformational rearrangement of the A43- containing region of U6 snRNA, thereby modifying the RNA structure to become suitable for productive catalysis by the methyltransferase region. The K-loop region occludes the S-adenosyl-L-methionine-binding pocket. Upon activation, conformation of the K-loop changes, allowing S-adenosyl-L-methionine-binding. Embryonic lethality: embryos develop until blastocyst stage but development is stopped around the time of implantation (PubMed:30197299). Defects are caused by dysregulation of MAT2A mRNAs (PubMed:30197299). Belongs to the methyltransferase superfamily. METTL16/RlmF family. According to a report, N6-methylation of MAT2A affects MAT2A mRNA stability instead of preventing splicing (PubMed:29262316). However, it was later shown that N6-methylation of MAT2A transcripts prevents recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production (By similarity). RNA methylation mRNA (N6-adenosine)-methyltransferase activity RNA binding nucleus mRNA catabolic process S-adenosylmethionine biosynthetic process methyltransferase activity posttranscriptional regulation of gene expression transferase activity U6 snRNA 3'-end binding methylation RNA stem-loop binding regulation of mRNA splicing, via spliceosome 23S rRNA (adenine(1618)-N(6))-methyltransferase activity mRNA destabilization rRNA base methylation mRNA methylation uc007kch.1 uc007kch.2 uc007kch.3 
ENSMUST00000141758.2 Gm11588 ENSMUST00000141758.2 Gm11588 (from geneSymbol) ENSMUST00000141758.1 uc287ipv.1 uc287ipv.2 uc287ipv.1 uc287ipv.2 
ENSMUST00000141769.8 Tmem51os1 ENSMUST00000141769.8 Tmem51os1 (from geneSymbol) AK158244 ENSMUST00000141769.1 ENSMUST00000141769.2 ENSMUST00000141769.3 ENSMUST00000141769.4 ENSMUST00000141769.5 ENSMUST00000141769.6 ENSMUST00000141769.7 uc008vpt.1 uc008vpt.2 uc008vpt.3 uc008vpt.1 uc008vpt.2 uc008vpt.3 
ENSMUST00000141787.2 A730011C13Rik ENSMUST00000141787.2 A730011C13Rik (from geneSymbol) AK083419 ENSMUST00000141787.1 uc290hln.1 uc290hln.2 uc290hln.1 uc290hln.2 
ENSMUST00000141806.3 Gm50238 ENSMUST00000141806.3 Gm50238 (from geneSymbol) BC058793 ENSMUST00000141806.1 ENSMUST00000141806.2 uc289iwm.1 uc289iwm.2 uc289iwm.1 uc289iwm.2 
ENSMUST00000141810.3 Gm57219 ENSMUST00000141810.3 Gm57219 (from geneSymbol) AK143626 ENSMUST00000141810.1 ENSMUST00000141810.2 uc291vbg.1 uc291vbg.2 uc291vbg.1 uc291vbg.2 
ENSMUST00000141811.2 Gm15404 ENSMUST00000141811.2 Gm15404 (from geneSymbol) ENSMUST00000141811.1 uc289nmm.1 uc289nmm.2 uc289nmm.1 uc289nmm.2 
ENSMUST00000141819.2 Gm11872 ENSMUST00000141819.2 Gm11872 (from geneSymbol) AK029221 ENSMUST00000141819.1 uc290ljt.1 uc290ljt.2 uc290ljt.1 uc290ljt.2 
ENSMUST00000141875.3 1700056N10Rik ENSMUST00000141875.3 1700056N10Rik (from geneSymbol) AK006816 ENSMUST00000141875.1 ENSMUST00000141875.2 uc057kux.1 uc057kux.2 uc057kux.3 uc057kux.1 uc057kux.2 uc057kux.3 
ENSMUST00000141889.8 Adamtsl1 ENSMUST00000141889.8 ADAMTS-like 1, transcript variant 3 (from RefSeq NM_001368621.1) A2AM52 ATL1_MOUSE ENSMUST00000141889.1 ENSMUST00000141889.2 ENSMUST00000141889.3 ENSMUST00000141889.4 ENSMUST00000141889.5 ENSMUST00000141889.6 ENSMUST00000141889.7 NM_001368621 Q8BLI0 uc290npd.1 uc290npd.2 Monomer. Secreted, extracellular space, extracellular matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BLI0-1; Sequence=Displayed; Name=2; IsoId=Q8BLI0-2; Sequence=VSP_039332, VSP_039333; Glycosylated (By similarity). O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)- (S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). Disulfide bonds are present. Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family. molecular_function extracellular region proteolysis biological_process peptidase activity uc290npd.1 uc290npd.2 
ENSMUST00000141892.3 1700112K13Rik ENSMUST00000141892.3 1700112K13Rik (from geneSymbol) AK007180 ENSMUST00000141892.1 ENSMUST00000141892.2 uc290pyz.1 uc290pyz.2 uc290pyz.3 uc290pyz.1 uc290pyz.2 uc290pyz.3 
ENSMUST00000141893.3 Dmrta2os ENSMUST00000141893.3 Dmrta2os (from geneSymbol) AK019375 ENSMUST00000141893.1 ENSMUST00000141893.2 uc290ord.1 uc290ord.2 uc290ord.3 uc290ord.1 uc290ord.2 uc290ord.3 
ENSMUST00000141930.2 Gm15816 ENSMUST00000141930.2 predicted gene 15816 (from RefSeq NR_169137.1) ENSMUST00000141930.1 NR_169137 uc291ysz.1 uc291ysz.2 uc291ysz.1 uc291ysz.2 
ENSMUST00000141935.2 Gm13393 ENSMUST00000141935.2 Gm13393 (from geneSymbol) ENSMUST00000141935.1 uc289umc.1 uc289umc.2 uc289umc.1 uc289umc.2 
ENSMUST00000142024.2 4933401B06Rik ENSMUST00000142024.2 RIKEN cDNA 4933401B06 gene (from RefSeq NR_033580.2) ENSMUST00000142024.1 NR_033580 uc012hns.1 uc012hns.2 uc012hns.3 uc012hns.1 uc012hns.2 uc012hns.3 
ENSMUST00000142025.2 Gm9750 ENSMUST00000142025.2 Gm9750 (from geneSymbol) AK048878 ENSMUST00000142025.1 uc008goo.1 uc008goo.2 uc008goo.1 uc008goo.2 
ENSMUST00000142029.2 Smim12 ENSMUST00000142029.2 small integral membrane protein 12 (from RefSeq NM_030252.2) ENSMUST00000142029.1 NM_030252 Q78RX3 SIM12_MOUSE uc008uuq.1 uc008uuq.2 Membrane ; Single-pass membrane protein Belongs to the SMIM12 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008uuq.1 uc008uuq.2 
ENSMUST00000142044.2 Gm15228 ENSMUST00000142044.2 Gm15228 (from geneSymbol) AK156063 ENSMUST00000142044.1 uc292rtc.1 uc292rtc.2 uc292rtc.1 uc292rtc.2 
ENSMUST00000142053.2 Gm15124 ENSMUST00000142053.2 Gm15124 (from geneSymbol) AK132954 ENSMUST00000142053.1 uc287szx.1 uc287szx.2 uc287szx.1 uc287szx.2 
ENSMUST00000142064.8 Dpy19l1 ENSMUST00000142064.8 dpy-19 like C-mannosyltransferase 1, transcript variant 2 (from RefSeq NM_001359948.1) A6X919 D19L1_MOUSE ENSMUST00000142064.1 ENSMUST00000142064.2 ENSMUST00000142064.3 ENSMUST00000142064.4 ENSMUST00000142064.5 ENSMUST00000142064.6 ENSMUST00000142064.7 NM_001359948 Q3UP31 Q8CD79 uc009opb.1 uc009opb.2 uc009opb.3 C-mannosyltransferase that mediates the C-mannosylation tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW consensus sequence (PubMed:28202721). C-mannosylates the first two tryptophans in the WxxWxxWxxC sequence motif in thrombospondin (TSP) type-1 repeats of UNC5A (PubMed:28202721). Regulates neurite extension during development (PubMed:27959946, PubMed:28202721). Reaction=a dolichyl beta-D-mannosyl phosphate + L-tryptophyl-[protein] = a dolichyl phosphate + C-alpha-D-mannosyl-L-tryptophyl-[protein] + H(+); Xref=Rhea:RHEA:77219, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:15365, Rhea:RHEA-COMP:18864, ChEBI:CHEBI:15378, ChEBI:CHEBI:29954, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:195646; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77220; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A6X919-1; Sequence=Displayed; Name=2; IsoId=A6X919-2; Sequence=VSP_029630; Name=3; IsoId=A6X919-3; Sequence=VSP_029629, VSP_029631; Highly expressed in glutamatergic neurons of the developing cerebral cortex. Belongs to the dpy-19 family. Sequence=CD352443; Type=Frameshift; Evidence=; mannosyltransferase activity nuclear inner membrane membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan uc009opb.1 uc009opb.2 uc009opb.3 
ENSMUST00000142068.3 4931413K12Rik ENSMUST00000142068.3 RIKEN cDNA 4931413K12 gene (from RefSeq NR_166698.1) ENSMUST00000142068.1 ENSMUST00000142068.2 NR_166698 uc288aft.1 uc288aft.2 uc288aft.3 uc288aft.1 uc288aft.2 uc288aft.3 
ENSMUST00000142076.3 Gm15935 ENSMUST00000142076.3 Gm15935 (from geneSymbol) ENSMUST00000142076.1 ENSMUST00000142076.2 uc288rks.1 uc288rks.2 uc288rks.3 uc288rks.1 uc288rks.2 uc288rks.3 
ENSMUST00000142087.2 Tmem141 ENSMUST00000142087.2 transmembrane protein 141, transcript variant 2 (from RefSeq NM_001109993.1) A2AJB2 D2Ertd217e ENSMUST00000142087.1 NM_001109993 TM141_MOUSE uc008isy.1 uc008isy.2 uc008isy.3 uc008isy.4 Membrane ; Multi-pass membrane protein Belongs to the TMEM141 family. Sequence=AK004380; Type=Frameshift; Evidence=; molecular_function membrane integral component of membrane uc008isy.1 uc008isy.2 uc008isy.3 uc008isy.4 
ENSMUST00000142107.2 Gm11626 ENSMUST00000142107.2 Gm11626 (from geneSymbol) ENSMUST00000142107.1 uc288cjt.1 uc288cjt.2 uc288cjt.1 uc288cjt.2 
ENSMUST00000142108.2 Gm12145 ENSMUST00000142108.2 Gm12145 (from geneSymbol) ENSMUST00000142108.1 uc287xmo.1 uc287xmo.2 uc287xmo.1 uc287xmo.2 
ENSMUST00000142137.2 Gm11250 ENSMUST00000142137.2 Gm11250 (from geneSymbol) ENSMUST00000142137.1 uc290nhc.1 uc290nhc.2 uc290nhc.1 uc290nhc.2 
ENSMUST00000142188.2 4930505O20Rik ENSMUST00000142188.2 4930505O20Rik (from geneSymbol) AK015711 ENSMUST00000142188.1 uc292bhd.1 uc292bhd.2 uc292bhd.1 uc292bhd.2 
ENSMUST00000142212.4 Gm16751 ENSMUST00000142212.4 Gm16751 (from geneSymbol) AK143942 ENSMUST00000142212.1 ENSMUST00000142212.2 ENSMUST00000142212.3 uc290cfy.1 uc290cfy.2 uc290cfy.1 uc290cfy.2 
ENSMUST00000142247.8 Gm44505 ENSMUST00000142247.8 predicted readthrough transcript (NMD candidate), 44505 (from RefSeq NR_024093.1) E0CY81 E0CY81_MOUSE ENSMUST00000142247.1 ENSMUST00000142247.2 ENSMUST00000142247.3 ENSMUST00000142247.4 ENSMUST00000142247.5 ENSMUST00000142247.6 ENSMUST00000142247.7 Gm44505 NR_024093 uc289rdd.1 uc289rdd.2 This gene represents a read-through transcript composed of Zfp91 and Cntf sequences. This transcript is thought to be non-coding because it would be subject to nonsense-mediated mRNA decay (NMD). Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. [provided by RefSeq, Aug 2008]. Sequence Note: This RefSeq transcript was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 12803, 109910 ##RefSeq-Attributes-END## nucleic acid binding uc289rdd.1 uc289rdd.2 
ENSMUST00000142268.3 Lrrc3c ENSMUST00000142268.3 leucine rich repeat containing 3C (from RefSeq NM_001195544.1) A0A1B0GRI5 A0A1B0GRI5_MOUSE ENSMUST00000142268.1 ENSMUST00000142268.2 Lrrc3c NM_001195544 uc011yed.1 uc011yed.2 extracellular space membrane integral component of membrane extracellular matrix uc011yed.1 uc011yed.2 
ENSMUST00000142270.2 4932412D23Rik ENSMUST00000142270.2 RIKEN cDNA 4932412D23 gene, transcript variant 1 (from RefSeq NR_040521.1) ENSMUST00000142270.1 NR_040521 uc007zfw.1 uc007zfw.2 uc007zfw.3 uc007zfw.1 uc007zfw.2 uc007zfw.3 
ENSMUST00000142279.2 Gm11494 ENSMUST00000142279.2 Gm11494 (from geneSymbol) AK085785 ENSMUST00000142279.1 uc288bii.1 uc288bii.2 uc288bii.1 uc288bii.2 
ENSMUST00000142283.4 Homez ENSMUST00000142283.4 homeodomain leucine zipper-encoding gene, transcript variant 1 (from RefSeq NM_001177705.2) A0A0R4J108 A0A0R4J108_MOUSE ENSMUST00000142283.1 ENSMUST00000142283.2 ENSMUST00000142283.3 Homez NM_001177705 uc007txd.1 uc007txd.2 uc007txd.3 uc007txd.4 uc007txd.5 Nucleus DNA binding nucleus nucleolus cytosol uc007txd.1 uc007txd.2 uc007txd.3 uc007txd.4 uc007txd.5 
ENSMUST00000142286.2 Gm15813 ENSMUST00000142286.2 predicted gene 15813 (from RefSeq NR_188799.1) ENSMUST00000142286.1 NR_188799 uc288mji.1 uc288mji.2 uc288mji.1 uc288mji.2 
ENSMUST00000142289.2 Gm13008 ENSMUST00000142289.2 Gm13008 (from geneSymbol) ENSMUST00000142289.1 uc290qxq.1 uc290qxq.2 uc290qxq.1 uc290qxq.2 
ENSMUST00000142310.2 Gm14225 ENSMUST00000142310.2 Gm14225 (from geneSymbol) ENSMUST00000142310.1 uc290bya.1 uc290bya.2 uc290bya.1 uc290bya.2 
ENSMUST00000142312.3 Hoxd11 ENSMUST00000142312.3 homeobox D11, transcript variant 1 (from RefSeq NM_008273.2) A2ASM7 A2ASM7_MOUSE ENSMUST00000142312.1 ENSMUST00000142312.2 Hoxd11 NM_008273 uc008kdw.1 uc008kdw.2 uc008kdw.3 uc008kdw.4 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus Belongs to the Abd-B homeobox family. DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated sequence-specific DNA binding uc008kdw.1 uc008kdw.2 uc008kdw.3 uc008kdw.4 
ENSMUST00000142314.2 Gm13601 ENSMUST00000142314.2 Gm13601 (from geneSymbol) ENSMUST00000142314.1 uc289woo.1 uc289woo.2 uc289woo.1 uc289woo.2 
ENSMUST00000142322.2 Gm11948 ENSMUST00000142322.2 Gm11948 (from geneSymbol) ENSMUST00000142322.1 KY467562 uc287wdq.1 uc287wdq.2 uc287wdq.1 uc287wdq.2 
ENSMUST00000142352.9 Apoc2 ENSMUST00000142352.9 apolipoprotein C2, transcript variant 1 (from RefSeq NM_001277944.1) Apoc2 D3YXE8 ENSMUST00000142352.1 ENSMUST00000142352.2 ENSMUST00000142352.3 ENSMUST00000142352.4 ENSMUST00000142352.5 ENSMUST00000142352.6 ENSMUST00000142352.7 ENSMUST00000142352.8 NM_001277944 Q3UJG0 Q3UJG0_MOUSE uc012fbh.1 uc012fbh.2 uc012fbh.3 Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Secreted Belongs to the apolipoprotein C2 family. lipid metabolic process lipid transport enzyme activator activity chylomicron positive regulation of catalytic activity uc012fbh.1 uc012fbh.2 uc012fbh.3 
ENSMUST00000142353.2 Gm13575 ENSMUST00000142353.2 Gm13575 (from geneSymbol) AK033835 ENSMUST00000142353.1 uc289wlo.1 uc289wlo.2 uc289wlo.1 uc289wlo.2 
ENSMUST00000142373.3 Gm11899 ENSMUST00000142373.3 Gm11899 (from geneSymbol) AK052881 ENSMUST00000142373.1 ENSMUST00000142373.2 uc008sec.1 uc008sec.2 uc008sec.3 uc008sec.1 uc008sec.2 uc008sec.3 
ENSMUST00000142374.2 Gm14236 ENSMUST00000142374.2 Gm14236 (from geneSymbol) AK027991 ENSMUST00000142374.1 uc008oan.1 uc008oan.2 uc008oan.1 uc008oan.2 
ENSMUST00000142407.8 Ube2k ENSMUST00000142407.8 ubiquitin-conjugating enzyme E2K, transcript variant 1 (from RefSeq NM_016786.4) ENSMUST00000142407.1 ENSMUST00000142407.2 ENSMUST00000142407.3 ENSMUST00000142407.4 ENSMUST00000142407.5 ENSMUST00000142407.6 ENSMUST00000142407.7 Hip2 NM_016786 Q6ZWQ6 Q6ZWQ6_MOUSE Ube2k uc008xnu.1 uc008xnu.2 uc008xnu.3 uc008xnu.4 Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding ubiquitin-protein transferase activity ATP binding cell positive regulation of peptidyl-threonine phosphorylation free ubiquitin chain polymerization transferase activity ubiquitin protein ligase binding ubiquitin-ubiquitin ligase activity cellular response to interferon-beta positive regulation of type I interferon-mediated signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress protein K48-linked ubiquitination uc008xnu.1 uc008xnu.2 uc008xnu.3 uc008xnu.4 
ENSMUST00000142443.8 Gm44579 ENSMUST00000142443.8 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q1P2) AK138449 E9Q1P2 E9Q1P2_MOUSE ENSMUST00000142443.1 ENSMUST00000142443.2 ENSMUST00000142443.3 ENSMUST00000142443.4 ENSMUST00000142443.5 ENSMUST00000142443.6 ENSMUST00000142443.7 Gm44579 Olfr288 Or10ad1c uc289azx.1 uc289azx.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289azx.1 uc289azx.2 
ENSMUST00000142461.2 ENSMUSG00000121749 ENSMUST00000142461.2 ENSMUSG00000121749 (from geneSymbol) ENSMUST00000142461.1 uc289iwk.1 uc289iwk.2 uc289iwk.1 uc289iwk.2 
ENSMUST00000142509.2 Gssos1 ENSMUST00000142509.2 Gssos1 (from geneSymbol) AK002817 ENSMUST00000142509.1 uc290bsd.1 uc290bsd.2 uc290bsd.1 uc290bsd.2 
ENSMUST00000142520.2 Gm11788 ENSMUST00000142520.2 Gm11788 (from geneSymbol) ENSMUST00000142520.1 uc288efx.1 uc288efx.2 uc288efx.1 uc288efx.2 
ENSMUST00000142569.2 2310005A03Rik ENSMUST00000142569.2 RIKEN cDNA 2310005A03 gene (from RefSeq NR_040634.1) ENSMUST00000142569.1 NR_040634 uc029uhk.1 uc029uhk.2 uc029uhk.3 uc029uhk.1 uc029uhk.2 uc029uhk.3 
ENSMUST00000142609.8 Tmcc2 ENSMUST00000142609.8 transmembrane and coiled-coil domains 2, transcript variant 3 (from RefSeq NM_001311108.1) ENSMUST00000142609.1 ENSMUST00000142609.2 ENSMUST00000142609.3 ENSMUST00000142609.4 ENSMUST00000142609.5 ENSMUST00000142609.6 ENSMUST00000142609.7 NM_001311108 Q3T9T1 Q3T9T1_MOUSE Tmcc2 uc007cor.1 uc007cor.2 uc007cor.3 uc007cor.4 Belongs to the TEX28 family. membrane integral component of membrane uc007cor.1 uc007cor.2 uc007cor.3 uc007cor.4 
ENSMUST00000142625.2 Gm16122 ENSMUST00000142625.2 Gm16122 (from geneSymbol) AK135116 ENSMUST00000142625.1 uc291bhb.1 uc291bhb.2 uc291bhb.1 uc291bhb.2 
ENSMUST00000142634.3 Ube2uos ENSMUST00000142634.3 Ube2uos (from geneSymbol) AK085758 ENSMUST00000142634.1 ENSMUST00000142634.2 uc008tvf.1 uc008tvf.2 uc008tvf.3 uc008tvf.1 uc008tvf.2 uc008tvf.3 
ENSMUST00000142678.2 Gm15880 ENSMUST00000142678.2 predicted gene 15880 (from RefSeq NR_040343.1) ENSMUST00000142678.1 NR_040343 uc009iba.1 uc009iba.2 uc009iba.3 uc009iba.1 uc009iba.2 uc009iba.3 
ENSMUST00000142734.8 Lgals3 ENSMUST00000142734.8 lectin, galactose binding, soluble 3, transcript variant 2 (from RefSeq NM_010705.3) ENSMUST00000142734.1 ENSMUST00000142734.2 ENSMUST00000142734.3 ENSMUST00000142734.4 ENSMUST00000142734.5 ENSMUST00000142734.6 ENSMUST00000142734.7 Lgals3 NM_010705 Q8C253 Q8C253_MOUSE uc007tia.1 uc007tia.2 uc007tia.3 uc007tia.4 Secreted immunological synapse monocyte chemotaxis nucleus cytoplasm mitochondrial inner membrane IgE binding protein phosphatase binding carbohydrate binding neutrophil chemotaxis epithelial cell differentiation chemoattractant activity regulation of T cell proliferation laminin binding negative regulation of endocytosis eosinophil chemotaxis macrophage chemotaxis positive chemotaxis regulation of T cell apoptotic process mononuclear cell migration positive regulation of mononuclear cell migration positive regulation of protein homodimerization activity positive regulation of calcium ion import regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of protein localization to plasma membrane negative regulation of extrinsic apoptotic signaling pathway uc007tia.1 uc007tia.2 uc007tia.3 uc007tia.4 
ENSMUST00000142739.8 Nlk ENSMUST00000142739.8 nemo like kinase (from RefSeq NM_008702.3) ENSMUST00000142739.1 ENSMUST00000142739.2 ENSMUST00000142739.3 ENSMUST00000142739.4 ENSMUST00000142739.5 ENSMUST00000142739.6 ENSMUST00000142739.7 NLK_MOUSE NM_008702 Nlk O54949 Q5SYE6 Q6PF98 uc007kjw.1 uc007kjw.2 uc007kjw.3 Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination (PubMed:10391247, PubMed:11745377, PubMed:12482967, PubMed:12556497, PubMed:14720327, PubMed:15004007, PubMed:17785444, PubMed:18765672, PubMed:20874444, PubMed:21118996, PubMed:9448268). Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2 (PubMed:15004007). Negative regulator of the canonical Wnt/beta-catenin signaling pathway (PubMed:20194509). Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1 (PubMed:12556497). Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes (PubMed:12556497). Negative regulator of the Notch signaling pathway (PubMed:20118921). Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1 (PubMed:20118921). Negative regulator of the MYB family of transcription factors (PubMed:16055500). Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP (PubMed:15082531, PubMed:15308626, PubMed:16055500). Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself (PubMed:15082531, PubMed:15308626, PubMed:16055500). Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (PubMed:15004007). Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members (By similarity). Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (By similarity). Acts as an inhibitor of the mTORC1 complex in response to osmotic stress by mediating phosphorylation of RPTOR, thereby preventing recruitment of the mTORC1 complex to lysosomes (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Activated by the non-canonical Wnt signaling pathway, in which WNT5A leads to activation of MAP3K7/TAK1 and HIPK2, which subsequently phosphorylates and activates this protein. Activated by dimerization and subsequent intermolecular autophosphorylation on Thr-298. Other cytokines such as IL6 may also activate this regulatory circuit. Homodimer. Homodimerization is required for intermolecular autophosphorylation, kinase activation and nuclear localization (PubMed:21118996). Interacts with RNF138/NARF (By similarity). Interacts with FOXO1 and FOXO3 (By similarity). Interacts with the upstream activating kinases HIPK2 and MAP3K7/TAK1. Interaction with MAP3K7/TAK1 seems to be indirect, and may be mediated by other proteins such as STAT3, TAB1 and TAB2. Interacts with and phosphorylates a number of transcription factors including FOXO4, LEF1, MYB, MYBL1, MYBL2, NOTCH1 and TCF7L2/TCF4. May interact with components of cullin- RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Interacts with MEF2A (PubMed:12556497, PubMed:15004007, PubMed:15082531, PubMed:15308626, PubMed:16055500, PubMed:17785444, PubMed:18765672, PubMed:20118921, PubMed:20194509, PubMed:20874444). Interacts with ATF5; the interaction stabilizes ATF5 at the protein level in a kinase-independent manner (By similarity). O54949; Q9QZR5: Hipk2; NbExp=2; IntAct=EBI-366894, EBI-366905; Nucleus toplasm Note=Predominantly nuclear. A smaller fraction is cytoplasmic. Expressed at high levels in the brain, and at lower levels in heart, kidney, lung and liver. Contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. This mode of activation contrasts with that of classical MAP kinases, which contain a TXY activation loop motif in which phosphorylation of both the threonine and tyrosine residues is required for kinase activation. Phosphorylated on Thr-298. Intermolecular autophosphorylation on Thr-298 activates the enzyme. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Sequence=AAC24499.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; MAPK cascade nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity protein binding ATP binding nucleus cytoplasm regulation of transcription, DNA-templated protein phosphorylation transforming growth factor beta receptor signaling pathway transcription factor binding regulation of gene expression Wnt signaling pathway kinase activity phosphorylation transferase activity peptidyl-threonine phosphorylation negative regulation of Wnt signaling pathway ubiquitin protein ligase binding intracellular signal transduction SH2 domain binding serine phosphorylation of STAT protein protein autophosphorylation metal ion binding protein stabilization uc007kjw.1 uc007kjw.2 uc007kjw.3 
ENSMUST00000142742.9 Nos1 ENSMUST00000142742.9 nitric oxide synthase 1, neuronal (from RefSeq NM_008712.3) ENSMUST00000142742.1 ENSMUST00000142742.2 ENSMUST00000142742.3 ENSMUST00000142742.4 ENSMUST00000142742.5 ENSMUST00000142742.6 ENSMUST00000142742.7 ENSMUST00000142742.8 NM_008712 NOS1_MOUSE Nos1 Q3UR10 Q64208 Q9Z0J4 uc008zfy.1 uc008zfy.2 uc008zfy.3 uc008zfy.4 uc008zfy.5 Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Isoform NNOS Mu may be an effector enzyme for the dystrophin complex. Reaction=H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide; Xref=Rhea:RHEA:19897, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16480, ChEBI:CHEBI:32682, ChEBI:CHEBI:57743, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.39; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19898; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD. ; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Note=Binds 1 FMN. ; Name=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin; Xref=ChEBI:CHEBI:59560; Evidence=; Note=Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme. ; Stimulated by calcium/calmodulin. Inhibited by DYNLL1 that prevents the dimerization of the protein. Inhibited by NOSIP. Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON (By similarity). Forms a ternary complex with CAPON and RASD1 (PubMed:11086993). Forms a ternary complex with CAPON and SYN1 (By similarity). Interacts with ZDHHC23 (By similarity). Interacts with NOSIP; which may impair its synaptic location (By similarity). Interacts with HTR4 (PubMed:15466885). Interacts with VAC14 (By similarity). Interacts (via N-terminal domain) with DLG4 (via N-terminal tandem pair of PDZ domains) (PubMed:10623522). Interacts with SLC6A4 (PubMed:17452640). Forms a complex with ASL, ASS1 and SLC7A1; the complex regulates cell- autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway (PubMed:22081021). Interacts with DMD; localizes NOS1 to sarcolemma in muscle cells (PubMed:7545544). Interacts with DYNLL1; inhibits the nitric oxide synthase activity (By similarity). Q9Z0J4; Q05769: Ptgs2; NbExp=4; IntAct=EBI-397596, EBI-298933; Q9Z0J4; Q60857: Slc6a4; NbExp=4; IntAct=EBI-397596, EBI-15633326; Cell membrane, sarcolemma ; Peripheral membrane protein Cell projection, dendritic spine Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex (PubMed:7545544). In neurons, enriched in dendritic spines (By similarity). Event=Alternative splicing; Named isoforms=5; Name=N-NOS-1; IsoId=Q9Z0J4-1; Sequence=Displayed; Name=N-NOS-2; IsoId=Q9Z0J4-2; Sequence=VSP_003578; Name=NNOS beta; IsoId=Q9Z0J4-3; Sequence=VSP_003575, VSP_003576; Name=NNOS gamma; IsoId=Q9Z0J4-4; Sequence=VSP_003577; Name=NNOS Mu; Synonyms=Muscle-specific; IsoId=Q9Z0J4-5; Sequence=VSP_003579; Widely expressed in the nervous system: expressed in cerebrum, olfactory bulb, hippocampus, midbrain, cerebellum, pons, medulla oblongata, and spinal cord. Also found in skeletal muscle, where it is localized beneath the sarcolemma of fast twitch muscle fibers, and in spleen, heart, kidney, and liver. N-NOS-1 and N-NOS-2 are found in all parts of the nervous system. NNOS beta and gamma occur in a region-specific manner in the brain and NNOS beta expression is developmentally regulated. NNOS Mu is only found in mature skeletal and cardiac muscles. By cholinergic agonists acting at inositol phosphate-linked muscarinic receptors in cardiac myocytes. The PDZ domain participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes. Mediates interaction with VAC14. Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro). Note=In MDX mice (mouse model of dystrophinopathy) the dystrophin complex is disrupted and nNOS is displaced from sarcolemma and accumulates in the cytosol. Belongs to the NOS family. response to hypoxia photoreceptor inner segment regulation of sodium ion transport NADPH-hemoprotein reductase activity nitric-oxide synthase activity protein binding calmodulin binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane cytosol cytoskeleton plasma membrane arginine catabolic process nitric oxide biosynthetic process striated muscle contraction nitric oxide mediated signal transduction regulation of heart contraction zinc ion binding negative regulation of cell proliferation response to heat response to hormone FMN binding vesicle membrane postsynaptic density membrane oxidoreductase activity sarcoplasmic reticulum sodium channel regulator activity peptidyl-cysteine S-nitrosylation enzyme binding heme binding Z disc secretory granule T-tubule dendrite positive regulation of guanylate cyclase activity nuclear membrane response to lipopolysaccharide macromolecular complex sarcoplasmic reticulum membrane negative regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation multicellular organismal response to stress negative regulation of iron ion transmembrane transport positive regulation of histone acetylation vasodilation sarcolemma azurophil granule exogenous drug catabolic process protein homodimerization activity cell projection negative regulation of apoptotic process dendritic spine negative regulation of potassium ion transport response to peptide hormone negative regulation of neuron apoptotic process response to estrogen calyx of Held ion channel binding membrane raft establishment of protein localization synapse negative regulation of blood pressure negative regulation of heart contraction positive regulation of transcription, DNA-templated negative regulation of vasoconstriction positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion cadmium ion binding metal ion binding behavioral response to cocaine perinuclear region of cytoplasm flavin adenine dinucleotide binding NADP binding regulation of neurogenesis ATPase binding phosphoprotein binding negative regulation of hydrolase activity negative regulation of cytosolic calcium ion concentration negative regulation of serotonin uptake negative regulation of calcium ion transport regulation of sensory perception of pain oxidation-reduction process NADPH binding cellular response to mechanical stimulus cellular response to growth factor stimulus cellular response to epinephrine stimulus scaffold protein binding positive regulation of the force of heart contraction retrograde trans-synaptic signaling by nitric oxide glutamatergic synapse postsynaptic specialization, intracellular component postsynaptic density, intracellular component positive regulation of long-term synaptic potentiation positive regulation of neuron death positive regulation of sodium ion transmembrane transport caveola uc008zfy.1 uc008zfy.2 uc008zfy.3 uc008zfy.4 uc008zfy.5 
ENSMUST00000142751.2 Gm11747 ENSMUST00000142751.2 predicted gene 11747 (from RefSeq NR_045902.1) ENSMUST00000142751.1 NR_045902 uc029rqa.1 uc029rqa.2 uc029rqa.1 uc029rqa.2 
ENSMUST00000142774.3 Gm13389 ENSMUST00000142774.3 Gm13389 (from geneSymbol) AK082173 ENSMUST00000142774.1 ENSMUST00000142774.2 uc289svp.1 uc289svp.2 uc289svp.3 uc289svp.1 uc289svp.2 uc289svp.3 
ENSMUST00000142815.2 C530005A16Rik ENSMUST00000142815.2 RIKEN cDNA C530005A16 gene (from RefSeq NR_029450.1) ENSMUST00000142815.1 NR_029450 uc008ugs.1 uc008ugs.2 uc008ugs.1 uc008ugs.2 
ENSMUST00000142822.4 Apela ENSMUST00000142822.4 apelin receptor early endogenous ligand, transcript variant 1 (from RefSeq NM_001297554.2) Apela ELA_MOUSE ENSMUST00000142822.1 ENSMUST00000142822.2 ENSMUST00000142822.3 Ela Ende Gm10664 NM_001297554 P0DMC4 Tdl uc009lvh.1 uc009lvh.2 uc009lvh.3 uc009lvh.4 Endogenous ligand for the apelin receptor (APLNR) (By similarity). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis (PubMed:28371822, PubMed:28854362, PubMed:28890073, PubMed:28663440). Drives internalization of the APLNR (By similarity). Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating APLNR (By similarity). Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells (PubMed:28854362). May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting (PubMed:28890073). Plays a role in placental vascular development; promotes placental trophoblast invasion and spiral artery remodeling in the uterus (PubMed:28663440). Involved in the regulation of maternal cardiovascular homeostasis to prevent gestational hypertension and for potent cardioprotective functions during heart failure (PubMed:28371822, PubMed:28663440). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). Interacts with APLNR. Secreted Secreted, extracellular space Note=Found in blood plasma (By similarity). Found in serum of pregnant mice, peaking at midgestation; indicating a maternal and zygotic origin of circulating APELA during pregnancy (PubMed:28663440). Expressed in the placenta (PubMed:28663440). Expressed in syncytiotrophoblasts of the placenta labyrinth at 10.5 dpc (PubMed:28663440). Expressed in placental chorionic trophoblasts (at protein level) (PubMed:28663440). Expressed in a small population of epiblast cells in the distal half of the embryo at 7 dpc (PubMed:20153842, PubMed:28854362). Expressed in newly formed definitive endoderm cells in the proximal half of the embryo, while it is not present in extra-embryonic endoderm at 7.5 dpc (PubMed:20153842, PubMed:28854362). This expression pattern then changes to the ventral aspect of the developing foregut pocket and the entire hindgut pocket at 8.5 dpc, before becoming restricted to the foregut overlying the heart and the posterior-most hindgut (PubMed:20153842). Not detected in endothelial precursor cells of the yolk sac at 8 dpc (PubMed:28663440). Expressed in extraembryonic tissues as well as in the chorion at 8.25 dpc (PubMed:28854362). Expressed in endometrial stroma of the uterus of pregnant mice at 8.5 dpc (PubMed:28663440). Expressed in the developing heart, caudal neural tube and trophobasts at 9 dpc (PubMed:28663440). Expressed in the chorionic plate of the chorioallantoic placenta at 9 dpc (PubMed:28663440). Expressed in the posterior half of the ventral neural tube at 9.25 dpc (PubMed:20153842). Expressed in trophoblast cells at the periphery of the placenta at 9.5 dpc (PubMed:28854362). Expressed in collecting ducts of the kidney of pregnant mice at 10.5 dpc (PubMed:28663440). Expressed in the epicardium of the developing heart at 11.5 dpc (PubMed:26611206, PubMed:28890073). Expressed weakly in the adult heart (PubMed:26611206). Expressed in endothelial cells and fibroblasts and weakly in cardiomyocytes (PubMed:26611206). Expressed during early embryonic development from the two cell to blastocyst stages (PubMed:28663440). Expressed in populations of the definitive endoderm from 7 to 8.5 dpc (PubMed:20153842). Up-regulated following myocardial infarction (MI) (at protein level) (PubMed:26611206). Mice lacking APELA are not represented at the expected Mendelian ratios (PubMed:28854362, PubMed:28663440). Mutant embryos exhibit around 10% to 50% incidence of incomplete penetrance of embryonic lethality (PubMed:28854362, PubMed:28663440). Fetal death is increased especially in mothers devoid of all Apela expression (PubMed:28663440). Mutant embryos show extraembryonic tissues anomalies, such as ectopic anterior chorion, mesoderm yolk sac and blood island protrusions and reduced allantois thickness at 8.25 dpc (PubMed:28854362). Mutant embryos show improper establishment of the fetal-maternal circulation, such as underdeveloped yolk sac vasculature, embryonic vascular malformations and impaired cardiac tube looping at 9.5 and 10.5 dpc (PubMed:28854362, PubMed:28663440). Show also defect in somitic vasculature at 10.5 dpc. The heart of mutant embryos show reduced coronary vessel growth at 13.5 dpc and 15.5 dpc (PubMed:28890073). The placenta of mutant pregnant mice show decreased labyrinth thickness, poor vasculature and decreased cell proliferation (PubMed:28663440). Mutant pregnant mice that survived to adulthood developed preeclampsia, including increased systolic blood pressure, proteinuria, and glomerular endotheliosis (PubMed:28663440). Mutant embryos show altered expression of several erythroid and myeloid progenitor genes at 7.5 dpc (PubMed:28854362). Mutant embryos show increased expression of hypoxia-related genes in the placenta at 10.5 (PubMed:28663440). Double knockout mice of APELA and APLN genes exhibit the same penetrance, embryonic lethality and cardiovascular malformations as single APELA knockout mice (PubMed:28854362). Belongs to the Elabela/Toddler family. Sequence=AK014119; Type=Frameshift; Evidence=; angiogenesis vasculogenesis hormone activity extracellular region extracellular space multicellular organism development gastrulation endoderm development heart development mesoderm migration involved in gastrulation cell differentiation apelin receptor binding embryonic heart tube development positive regulation of angiogenesis positive regulation of heart contraction apelin receptor signaling pathway SMAD protein signal transduction placenta blood vessel development coronary vasculature development positive regulation of ERK1 and ERK2 cascade mesendoderm migration cell migration involved in mesendoderm migration positive regulation of trophoblast cell migration positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis uc009lvh.1 uc009lvh.2 uc009lvh.3 uc009lvh.4 
ENSMUST00000142828.2 Gm13660 ENSMUST00000142828.2 Gm13660 (from geneSymbol) AK146150 ENSMUST00000142828.1 uc008kek.1 uc008kek.2 uc008kek.3 uc008kek.1 uc008kek.2 uc008kek.3 
ENSMUST00000142835.2 Gm12737 ENSMUST00000142835.2 Gm12737 (from geneSymbol) ENSMUST00000142835.1 uc290onq.1 uc290onq.2 uc290onq.1 uc290onq.2 
ENSMUST00000142837.3 Dennd4c ENSMUST00000142837.3 DENN domain containing 4C, transcript variant 1 (from RefSeq NM_184088.2) A2AJX5 A6H8H2 DEN4C_MOUSE ENSMUST00000142837.1 ENSMUST00000142837.2 NM_184088 Q3U2K9 uc290npx.1 uc290npx.2 Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. Cytoplasmic vesicle membrane Cell membrane Cytoplasm, cytosol Note=Associates with SLC2A4/GLUT4 storage vesicles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A6H8H2-1; Sequence=Displayed; Name=2; IsoId=A6H8H2-2; Sequence=VSP_044491; Phosphorylated in response to insulin. guanyl-nucleotide exchange factor activity cytoplasm cytosol plasma membrane protein transport membrane Rab guanyl-nucleotide exchange factor activity cytoplasmic vesicle membrane retromer complex cytoplasmic vesicle insulin-responsive compartment cellular response to insulin stimulus protein localization to plasma membrane uc290npx.1 uc290npx.2 
ENSMUST00000142850.9 Mbp ENSMUST00000142850.9 myelin basic protein, transcript variant 3 (from RefSeq NM_001025255.2) ENSMUST00000142850.1 ENSMUST00000142850.2 ENSMUST00000142850.3 ENSMUST00000142850.4 ENSMUST00000142850.5 ENSMUST00000142850.6 ENSMUST00000142850.7 ENSMUST00000142850.8 MBP_MOUSE NM_001025255 P04370 Q01585 Q03139 Q03176 Q61836 Q61837 Q99KE4 Q9QWP1 Shi uc289pur.1 uc289pur.2 uc289pur.3 The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called 'Golli-Mbp') that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]. The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Homodimer. [Isoform 13]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. [Isoform 12]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. [Isoform 11]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. [Isoform 10]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. [Isoform 9]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. [Isoform 8]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. [Isoform 7]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. [Isoform 6]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. [Isoform 5]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. [Isoform 4]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. [Isoform 3]: Cytoplasm. Nucleus. [Isoform 2]: Cytoplasm. Nucleus. [Isoform 1]: Cytoplasm. Nucleus. Event=Alternative splicing; Named isoforms=13; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Golli-MBP1, J37; IsoId=P04370-1; Sequence=Displayed; Name=2; Synonyms=Golli-MBP2, BG21, HMBPR; IsoId=P04370-2; Sequence=VSP_003314; Name=3; Synonyms=Golli-MBP3, TP8; IsoId=P04370-3; Sequence=VSP_003313; Name=4; Synonyms=21.5-kDa; IsoId=P04370-4; Sequence=VSP_003312, VSP_003315, VSP_003319; Name=5; Synonyms=18.5-kDa; IsoId=P04370-5; Sequence=VSP_003312, VSP_003319; Name=6; Synonyms=17-kDa-a; IsoId=P04370-6; Sequence=VSP_003312, VSP_003315, VSP_003318; Name=7; Synonyms=17-kDa-b; IsoId=P04370-7; Sequence=VSP_003312, VSP_003320; Name=8; Synonyms=14-kDa; IsoId=P04370-8; Sequence=VSP_003312, VSP_003318; Name=9; IsoId=P04370-9; Sequence=VSP_003312, VSP_003315, VSP_003320; Name=10; Synonyms=21-kDa; IsoId=P04370-10; Sequence=VSP_003312, VSP_003317; Name=11; Synonyms=19.7-kDa; IsoId=P04370-11; Sequence=VSP_003312, VSP_003315, VSP_003316; Name=12; Synonyms=15.6-kDa; IsoId=P04370-13; Sequence=VSP_003312, VSP_003315; Name=13; Synonyms=13-kDa; IsoId=P04370-14; Sequence=VSP_003312; In the embryo, isoform 1-isoform 3 are found in neurons within the central nervous system (primarily in pioneer neurons important in the formation of the cortex) and the peripheral nervous system. They are also expressed in the thymus, gut, lung and kidney. In the adult, isoform 1-isoform 3 are highly expressed in the brain (mainly in brain regions rich in oligodendrocytes) and spleen. Lower levels are seen in the heart, kidney and lung. Isoform 2 is also found in cells of the immune system. The isoforms missing the 134 first amino acids (isoform 4-isoform 13) are almost exclusively produced in the myelin-forming cells, the mature oligodendrocytes. The differential expression of MBP isoforms is developmentally regulated. Isoform 2 and isoform 3 are first expressed during embryonic stages (as early as at embryonic day 11.5), expression of isoform 1 is turned on shortly after birth. Expression of the isoforms missing the 134 first amino acids occurs later, presumably as the oligodendrocytes approach their terminally differentiated state. As in other animals, several charge isomers may be produced as a result of optional post-translational modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues. Methylated on arginine residues; decreases with the age of the animal, making MBP more cationic. Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1. Proteolytically cleaved in B cell lysosomes by cathepsin CTSG which degrades the major immunogenic MBP epitope and prevents the activation of MBP-specific autoreactive T cells. Note=Defects in Mbp are a cause of dysmyelinating diseases such as the shiverer (SHI) and myelin deficient (MLD) diseases characterized by decreased myelination in the CNS, tremors, and convulsions of progressively increasing severity leading to early death. The shiverer mice only express isoform 2, the MLD mice have a reduced amount of Mbp. Belongs to the myelin basic protein family. MAPK cascade protease binding calmodulin binding nucleus cytoplasm plasma membrane sensory perception of sound response to toxic substance membrane structural constituent of myelin sheath macromolecular complex internode region of axon negative regulation of heterotypic cell-cell adhesion maintenance of permeability of blood-brain barrier myelination cell projection neuronal cell body myelin sheath compact myelin membrane organization cell periphery positive regulation of chemokine (C-C motif) ligand 2 secretion positive regulation of metalloendopeptidase activity positive regulation of interleukin-6 secretion uc289pur.1 uc289pur.2 uc289pur.3 
ENSMUST00000142871.3 4930458D05Rik ENSMUST00000142871.3 4930458D05Rik (from geneSymbol) AK036594 ENSMUST00000142871.1 ENSMUST00000142871.2 uc008yig.1 uc008yig.2 uc008yig.3 uc008yig.4 uc008yig.1 uc008yig.2 uc008yig.3 uc008yig.4 
ENSMUST00000142962.4 Gm15631 ENSMUST00000142962.4 predicted gene 15631 (from RefSeq NR_132434.1) ENSMUST00000142962.1 ENSMUST00000142962.2 ENSMUST00000142962.3 NR_132434 uc009dcq.1 uc009dcq.2 uc009dcq.3 uc009dcq.4 uc009dcq.5 uc009dcq.1 uc009dcq.2 uc009dcq.3 uc009dcq.4 uc009dcq.5 
ENSMUST00000142968.3 Hk1os ENSMUST00000142968.3 hexokinase 1, opposite strand, transcript variant 4 (from RefSeq NR_168631.1) ENSMUST00000142968.1 ENSMUST00000142968.2 NR_168631 uc287rpp.1 uc287rpp.2 uc287rpp.3 uc287rpp.1 uc287rpp.2 uc287rpp.3 
ENSMUST00000143009.2 4933426K07Rik ENSMUST00000143009.2 4933426K07Rik (from geneSymbol) AK016935 ENSMUST00000143009.1 uc287yia.1 uc287yia.2 uc287yia.1 uc287yia.2 
ENSMUST00000143016.2 Gm12207 ENSMUST00000143016.2 Gm12207 (from geneSymbol) ENSMUST00000143016.1 uc287ybb.1 uc287ybb.2 uc287ybb.1 uc287ybb.2 
ENSMUST00000143025.2 Gm15622 ENSMUST00000143025.2 Gm15622 (from geneSymbol) AK016283 ENSMUST00000143025.1 uc288peg.1 uc288peg.2 uc288peg.1 uc288peg.2 
ENSMUST00000143043.8 Wt1 ENSMUST00000143043.8 WT1 transcription factor (from RefSeq NM_144783.2) ENSMUST00000143043.1 ENSMUST00000143043.2 ENSMUST00000143043.3 ENSMUST00000143043.4 ENSMUST00000143043.5 ENSMUST00000143043.6 ENSMUST00000143043.7 F6Y2T6 F6Y2T6_MOUSE NM_144783 Wt1 uc008lko.1 uc008lko.2 uc008lko.3 uc008lko.4 This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm's tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms. [provided by RefSeq, Apr 2013]. Sequence Note: A non-AUG (CUG) translation initiation codon is selected for this RefSeq based on experimental evidence provided in PMID:8621495, and for consistency with the human homolog. Alternative shorter isoforms, which are derived from downstream CUG and AUG initiation codons, are also described in PMID:8621495. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M55512.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 8621495 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cytoplasm Nucleus speckle Belongs to the EGR C2H2-type zinc-finger protein family. nucleic acid binding nucleus regulation of transcription, DNA-templated uc008lko.1 uc008lko.2 uc008lko.3 uc008lko.4 
ENSMUST00000143047.8 Smim1 ENSMUST00000143047.8 Regulator of red blood cell formation. (from UniProt P0C8K7) AK028394 ENSMUST00000143047.1 ENSMUST00000143047.2 ENSMUST00000143047.3 ENSMUST00000143047.4 ENSMUST00000143047.5 ENSMUST00000143047.6 ENSMUST00000143047.7 P0C8K7 SMIM1_MOUSE Smim1 uc012dqh.1 uc012dqh.2 uc012dqh.3 Regulator of red blood cell formation. Homooligomer; disulfide-linked. Cell membrane ; Single-pass type II membrane protein Belongs to the SMIM1 family. plasma membrane biological_process cell surface membrane integral component of membrane protein homodimerization activity uc012dqh.1 uc012dqh.2 uc012dqh.3 
ENSMUST00000143054.2 Taf13 ENSMUST00000143054.2 TATA-box binding protein associated factor 13 (from RefSeq NM_025444.2) ENSMUST00000143054.1 NM_025444 P61216 Q3TVE8 TAF13_MOUSE Taf13 Taf2k uc008qzh.1 uc008qzh.2 uc008qzh.3 The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre- initiation complex (PIC). The TFIID complex consists of TBP and TBP- associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes. Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP- associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TBP, and more strongly with TAF10 and TAF11. P61216; Q99JX1: Taf11; NbExp=3; IntAct=EBI-309424, EBI-309427; Nucleus The binding of TAF10 and TAF11 requires distinct domains of TAF13. Belongs to the TAF13 family. DNA binding transcription cofactor activity protein binding nucleus transcription factor TFIID complex nucleolus regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein C-terminus binding protein heterodimerization activity uc008qzh.1 uc008qzh.2 uc008qzh.3 
ENSMUST00000143062.4 Gm16001 ENSMUST00000143062.4 Gm16001 (from geneSymbol) ENSMUST00000143062.1 ENSMUST00000143062.2 ENSMUST00000143062.3 uc290ztd.1 uc290ztd.2 uc290ztd.3 uc290ztd.4 uc290ztd.1 uc290ztd.2 uc290ztd.3 uc290ztd.4 
ENSMUST00000143082.4 Saal1 ENSMUST00000143082.4 serum amyloid A-like 1, transcript variant 7 (from RefSeq NR_185017.1) ENSMUST00000143082.1 ENSMUST00000143082.2 ENSMUST00000143082.3 NR_185017 Q3UYS6 Q8R2L2 Q9D2C2 SAAL1_MOUSE uc009gyu.1 uc009gyu.2 uc009gyu.3 uc009gyu.4 Plays a role in promoting the proliferation of synovial fibroblasts in response to pro-inflammatory stimuli. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D2C2-1; Sequence=Displayed; Name=2; IsoId=Q9D2C2-2; Sequence=VSP_023483; Expressed in the synovial tissue of knee joints. Belongs to the SAAL1 family. molecular_function extracellular space nucleus biological_process uc009gyu.1 uc009gyu.2 uc009gyu.3 uc009gyu.4 
ENSMUST00000143099.2 6530409C15Rik ENSMUST00000143099.2 6530409C15Rik (from geneSymbol) AK018330 ENSMUST00000143099.1 uc291cyp.1 uc291cyp.2 uc291cyp.1 uc291cyp.2 
ENSMUST00000143103.2 Cdk19os ENSMUST00000143103.2 Cdk19os (from geneSymbol) AK016752 ENSMUST00000143103.1 uc287qre.1 uc287qre.2 uc287qre.1 uc287qre.2 
ENSMUST00000143107.2 Rpl27a ENSMUST00000143107.2 ribosomal protein L27A (from RefSeq NM_011975.4) ENSMUST00000143107.1 NM_011975 P14115 Q9CQ16 Q9R1X6 RL27A_MOUSE uc009jdr.1 uc009jdr.2 uc009jdr.3 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Cytoplasm Hydroxylated on His-39 by MINA. Belongs to the universal ribosomal protein uL15 family. structural constituent of ribosome endoplasmic reticulum cytosol ribosome translation large ribosomal subunit cytosolic large ribosomal subunit uc009jdr.1 uc009jdr.2 uc009jdr.3 
ENSMUST00000143109.2 Gm12524 ENSMUST00000143109.2 Gm12524 (from geneSymbol) AK046013 ENSMUST00000143109.1 uc290irm.1 uc290irm.2 uc290irm.1 uc290irm.2 
ENSMUST00000143110.2 Gm15086 ENSMUST00000143110.2 Gm15086 (from geneSymbol) ENSMUST00000143110.1 uc292rbi.1 uc292rbi.2 uc292rbi.1 uc292rbi.2 
ENSMUST00000143112.2 Gm7616 ENSMUST00000143112.2 predicted gene 7616 (from RefSeq NR_168957.1) ENSMUST00000143112.1 NR_168957 uc012guq.1 uc012guq.2 uc012guq.3 uc012guq.1 uc012guq.2 uc012guq.3 
ENSMUST00000143133.3 Gm833 ENSMUST00000143133.3 predicted gene 833 (from RefSeq NR_033138.1) ENSMUST00000143133.1 ENSMUST00000143133.2 NR_033138 uc290sfw.1 uc290sfw.2 uc290sfw.3 uc290sfw.1 uc290sfw.2 uc290sfw.3 
ENSMUST00000143135.2 Gm15592 ENSMUST00000143135.2 Gm15592 (from geneSymbol) ENSMUST00000143135.1 uc291ctp.1 uc291ctp.2 uc291ctp.1 uc291ctp.2 
ENSMUST00000143202.8 A730032A03Rik ENSMUST00000143202.8 A730032A03Rik (from geneSymbol) AK042861 ENSMUST00000143202.1 ENSMUST00000143202.2 ENSMUST00000143202.3 ENSMUST00000143202.4 ENSMUST00000143202.5 ENSMUST00000143202.6 ENSMUST00000143202.7 uc290cjo.1 uc290cjo.2 uc290cjo.1 uc290cjo.2 
ENSMUST00000143203.8 Stxbp4 ENSMUST00000143203.8 syntaxin binding protein 4 (from RefSeq NM_011505.3) ENSMUST00000143203.1 ENSMUST00000143203.2 ENSMUST00000143203.3 ENSMUST00000143203.4 ENSMUST00000143203.5 ENSMUST00000143203.6 ENSMUST00000143203.7 NM_011505 Q5SUA6 Q5SUA8 Q5SUA9 Q8CFL1 Q9WV89 STXB4_MOUSE uc007kwu.1 uc007kwu.2 uc007kwu.3 uc007kwu.4 uc007kwu.5 Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose. Interacts with STX4A. Cytoplasm Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9WV89-1; Sequence=Displayed; Name=2; IsoId=Q9WV89-2; Sequence=VSP_017183; Name=3; IsoId=Q9WV89-3; Sequence=VSP_017179, VSP_017180; Name=4; IsoId=Q9WV89-4; Sequence=VSP_017184, VSP_017185; Name=5; IsoId=Q9WV89-5; Sequence=VSP_017181, VSP_017182; Detected in skeletal muscle, heart, testis, adipocytes and pancreatic islet cells. Phosphorylated on Ser-99 by PKB/AKT2 after insulin treatment. Phosphorylation on Ser-99 abolishes the interaction with STX4A. protein binding cytoplasm protein targeting cellular response to DNA damage stimulus insulin receptor signaling pathway regulation of glucose transport positive regulation of keratinocyte proliferation syntaxin binding phagocytic vesicle protein stabilization regulation of insulin secretion involved in cellular response to glucose stimulus cellular response to interferon-gamma positive regulation of cell cycle G1/S phase transition uc007kwu.1 uc007kwu.2 uc007kwu.3 uc007kwu.4 uc007kwu.5 
ENSMUST00000143208.2 Gm15893 ENSMUST00000143208.2 Gm15893 (from geneSymbol) AK028492 ENSMUST00000143208.1 uc288bha.1 uc288bha.2 uc288bha.1 uc288bha.2 
ENSMUST00000143219.8 Pitpna ENSMUST00000143219.8 phosphatidylinositol transfer protein, alpha (from RefSeq NM_008850.2) ENSMUST00000143219.1 ENSMUST00000143219.2 ENSMUST00000143219.3 ENSMUST00000143219.4 ENSMUST00000143219.5 ENSMUST00000143219.6 ENSMUST00000143219.7 NM_008850 Pitpna Q5ND42 Q5ND42_MOUSE uc007kei.1 uc007kei.2 uc007kei.3 uc007kei.4 This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate by phosphoinositide-3-kinase. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK168720.1, U96725.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out); Xref=Rhea:RHEA:38691, ChEBI:CHEBI:57880; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38692; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38572; Evidence=; Belongs to the PtdIns transfer protein family. PI transfer class I subfamily. phospholipid transporter activity phosphatidylcholine transporter activity phosphatidylinositol transporter activity phospholipid transport phosphatidylcholine binding phosphatidylinositol binding uc007kei.1 uc007kei.2 uc007kei.3 uc007kei.4 
ENSMUST00000143227.2 Macrod2os2 ENSMUST00000143227.2 Macrod2os2 (from geneSymbol) AK158168 ENSMUST00000143227.1 uc290axk.1 uc290axk.2 uc290axk.1 uc290axk.2 
ENSMUST00000143245.8 Tmem150cos ENSMUST00000143245.8 transmembrane protein 150C, opposite strand (from RefSeq NR_045993.1) ENSMUST00000143245.1 ENSMUST00000143245.2 ENSMUST00000143245.3 ENSMUST00000143245.4 ENSMUST00000143245.5 ENSMUST00000143245.6 ENSMUST00000143245.7 NR_045993 uc008yhe.1 uc008yhe.2 uc008yhe.3 uc008yhe.1 uc008yhe.2 uc008yhe.3 
ENSMUST00000143261.8 Gm16152 ENSMUST00000143261.8 predicted gene 16152 (from RefSeq NR_190174.1) ENSMUST00000143261.1 ENSMUST00000143261.2 ENSMUST00000143261.3 ENSMUST00000143261.4 ENSMUST00000143261.5 ENSMUST00000143261.6 ENSMUST00000143261.7 NR_190174 uc007asw.1 uc007asw.2 uc007asw.1 uc007asw.2 
ENSMUST00000143266.2 Cd55os ENSMUST00000143266.2 CD55 molecule, opposite strand sequence (from RefSeq NR_151525.1) ENSMUST00000143266.1 NR_151525 uc287lmn.1 uc287lmn.2 uc287lmn.1 uc287lmn.2 
ENSMUST00000143278.8 Fam131b ENSMUST00000143278.8 family with sequence similarity 131, member B, transcript variant a (from RefSeq NM_029528.5) E9Q8P8 E9Q8P8_MOUSE ENSMUST00000143278.1 ENSMUST00000143278.2 ENSMUST00000143278.3 ENSMUST00000143278.4 ENSMUST00000143278.5 ENSMUST00000143278.6 ENSMUST00000143278.7 Fam131b NM_029528 uc009bqu.1 uc009bqu.2 uc009bqu.3 uc009bqu.4 uc009bqu.5 Belongs to the FAM131 family. nucleoplasm cytosol uc009bqu.1 uc009bqu.2 uc009bqu.3 uc009bqu.4 uc009bqu.5 
ENSMUST00000143286.8 Uty ENSMUST00000143286.8 Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)- [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- lysyl(27)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60224, Rhea:RHEA-COMP:15535, Rhea:RHEA-COMP:15544, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961; EC=1.14.11.68; Evidence=; (from UniProt E9Q504) AK162410 E9Q504 E9Q504_MOUSE ENSMUST00000143286.1 ENSMUST00000143286.2 ENSMUST00000143286.3 ENSMUST00000143286.4 ENSMUST00000143286.5 ENSMUST00000143286.6 ENSMUST00000143286.7 Uty uc009uzh.1 uc009uzh.2 uc009uzh.3 Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)- [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- lysyl(27)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60224, Rhea:RHEA-COMP:15535, Rhea:RHEA-COMP:15544, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961; EC=1.14.11.68; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Nucleus Belongs to the UTX family. regulation of gene expression membrane integral component of membrane metal ion binding histone H3-K27 demethylation histone demethylase activity (H3-K27 specific) uc009uzh.1 uc009uzh.2 uc009uzh.3 
ENSMUST00000143287.2 Gm15265 ENSMUST00000143287.2 Gm15265 (from geneSymbol) ENSMUST00000143287.1 uc290hlp.1 uc290hlp.2 uc290hlp.1 uc290hlp.2 
ENSMUST00000143291.3 Gm11752 ENSMUST00000143291.3 Gm11752 (from geneSymbol) ENSMUST00000143291.1 ENSMUST00000143291.2 uc288eah.1 uc288eah.2 uc288eah.3 uc288eah.1 uc288eah.2 uc288eah.3 
ENSMUST00000143302.2 Gm11521 ENSMUST00000143302.2 Gm11521 (from geneSymbol) ENSMUST00000143302.1 uc288bol.1 uc288bol.2 uc288bol.1 uc288bol.2 
ENSMUST00000143303.2 Tmem262 ENSMUST00000143303.2 transmembrane protein 262 (from RefSeq NM_001111317.2) Catsperh D3Z338 ENSMUST00000143303.1 NM_001111317 TM262_MOUSE Tmem262 uc008ghe.1 uc008ghe.2 uc008ghe.3 uc008ghe.4 Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG, CATSPERD, CATSPERE, CATSPERZ, C2CD6/CATSPERT, SLCO6C1, TMEM249, TMEM262 and EFCAB9 (PubMed:34225353). HSPA1 may be an additional auxiliary complex member (By similarity). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (PubMed:34225353). The auxiliary CATSPERB, CATSPERG2, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively (PubMed:34225353). SLCO6C1 interacts with CATSPERE and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex (PubMed:34225353). C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane (Probable). Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc008ghe.1 uc008ghe.2 uc008ghe.3 uc008ghe.4 
ENSMUST00000143315.3 D830044D21Rik ENSMUST00000143315.3 RIKEN cDNA D830044D21 gene (from RefSeq NR_171008.1) ENSMUST00000143315.1 ENSMUST00000143315.2 NR_171008 uc288sei.1 uc288sei.2 uc288sei.1 uc288sei.2 
ENSMUST00000143324.2 Gm10649 ENSMUST00000143324.2 Gm10649 (from geneSymbol) AK158984 ENSMUST00000143324.1 uc292bdn.1 uc292bdn.2 uc292bdn.1 uc292bdn.2 
ENSMUST00000143346.8 A730036I17Rik ENSMUST00000143346.8 RIKEN cDNA A730036I17 gene (from RefSeq NR_045838.1) ENSMUST00000143346.1 ENSMUST00000143346.2 ENSMUST00000143346.3 ENSMUST00000143346.4 ENSMUST00000143346.5 ENSMUST00000143346.6 ENSMUST00000143346.7 NR_045838 uc008mhn.1 uc008mhn.2 uc008mhn.3 uc008mhn.4 uc008mhn.1 uc008mhn.2 uc008mhn.3 uc008mhn.4 
ENSMUST00000143380.3 Aldh3b2 ENSMUST00000143380.3 aldehyde dehydrogenase 3 family, member B2 (from RefSeq NM_001177438.1) AL3B2_MOUSE Aldh3b2 E9Q3E1 ENSMUST00000143380.1 ENSMUST00000143380.2 NM_001177438 Q497U8 uc008fxw.1 uc008fxw.2 uc008fxw.3 uc008fxw.4 uc008fxw.5 Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence=; Reaction=2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+); Xref=Rhea:RHEA:33739, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17600, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate; Xref=Rhea:RHEA:44100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:25646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. Lipid droplet Expressed in testis, white adipose tissue, lung, small intestine, kidney, spleen and liver. Geranylgeranylation is important for localization to lipid droplets and enzyme activity. Belongs to the aldehyde dehydrogenase family. 3-chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity lipid particle ethanol catabolic process cellular aldehyde metabolic process oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity oxidation-reduction process uc008fxw.1 uc008fxw.2 uc008fxw.3 uc008fxw.4 uc008fxw.5 
ENSMUST00000143382.2 Gm12949 ENSMUST00000143382.2 Gm12949 (from geneSymbol) ENSMUST00000143382.1 uc287ywn.1 uc287ywn.2 uc287ywn.1 uc287ywn.2 
ENSMUST00000143400.8 Asb8 ENSMUST00000143400.8 ankyrin repeat and SOCS box-containing 8, transcript variant 3 (from RefSeq NM_001170711.1) A0A0R4J1W1 A0A0R4J1W1_MOUSE Asb8 ENSMUST00000143400.1 ENSMUST00000143400.2 ENSMUST00000143400.3 ENSMUST00000143400.4 ENSMUST00000143400.5 ENSMUST00000143400.6 ENSMUST00000143400.7 NM_001170711 uc011zyr.1 uc011zyr.2 uc011zyr.3 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Belongs to the ankyrin SOCS box (ASB) family. protein ubiquitination intracellular signal transduction uc011zyr.1 uc011zyr.2 uc011zyr.3 
ENSMUST00000143428.3 Gm11766 ENSMUST00000143428.3 Gm11766 (from geneSymbol) AK077811 ENSMUST00000143428.1 ENSMUST00000143428.2 uc007mrf.1 uc007mrf.2 uc007mrf.3 uc007mrf.1 uc007mrf.2 uc007mrf.3 
ENSMUST00000143429.2 Trp73os ENSMUST00000143429.2 Trp73os (from geneSymbol) AK076480 ENSMUST00000143429.1 uc290shi.1 uc290shi.2 uc290shi.1 uc290shi.2 
ENSMUST00000143435.2 Gm11670 ENSMUST00000143435.2 Gm11670 (from geneSymbol) ENSMUST00000143435.1 uc288dee.1 uc288dee.2 uc288dee.1 uc288dee.2 
ENSMUST00000143458.7 Gm13269 ENSMUST00000143458.7 Gm13269 (from geneSymbol) AK146025 ENSMUST00000143458.1 ENSMUST00000143458.2 ENSMUST00000143458.3 ENSMUST00000143458.4 ENSMUST00000143458.5 ENSMUST00000143458.6 uc008ikq.1 uc008ikq.2 uc008ikq.3 uc008ikq.1 uc008ikq.2 uc008ikq.3 
ENSMUST00000143467.8 Plgrkt ENSMUST00000143467.8 plasminogen receptor, C-terminal lysine transmembrane protein (from RefSeq NM_026362.2) ENSMUST00000143467.1 ENSMUST00000143467.2 ENSMUST00000143467.3 ENSMUST00000143467.4 ENSMUST00000143467.5 ENSMUST00000143467.6 ENSMUST00000143467.7 NM_026362 PLRKT_MOUSE Q3TCJ3 Q9D3P8 uc008hdf.1 uc008hdf.2 uc008hdf.3 Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator- dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9. Interacts with PLAT. Interacts with PLAUR (By similarity). Cell membrane ulti-pass membrane protein Note=Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/Plaur. Expressed in monocytes; detected in differentiated monocytes but not in progenitor cells. Expressed in adrenal medulla and hippocampus. protein binding mitochondrion plasma membrane integral component of plasma membrane chemotaxis inflammatory response positive regulation of plasminogen activation membrane integral component of membrane uc008hdf.1 uc008hdf.2 uc008hdf.3 
ENSMUST00000143469.2 Gm13448 ENSMUST00000143469.2 Gm13448 (from geneSymbol) AK042120 ENSMUST00000143469.1 uc289vkv.1 uc289vkv.2 uc289vkv.1 uc289vkv.2 
ENSMUST00000143473.2 Gm11201 ENSMUST00000143473.2 predicted gene 11201 (from RefSeq NR_045873.1) ENSMUST00000143473.1 NR_045873 uc288apx.1 uc288apx.2 uc288apx.1 uc288apx.2 
ENSMUST00000143514.3 Arfip1 ENSMUST00000143514.3 ADP-ribosylation factor interacting protein 1, transcript variant 1 (from RefSeq NM_001081093.2) A2RSX9 ARFP1_MOUSE Arfip1 E9Q3G5 ENSMUST00000143514.1 ENSMUST00000143514.2 G5E8V9 NM_001081093 uc008pqe.1 uc008pqe.2 uc008pqe.3 uc008pqe.4 Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. Forms homodimers or heterodimers with ARFIP2. Interacts with non-myristoylated GTP-bound ARF3, but not to GDP-bound ARF3. Interacts with ARF1. Binds with lower affinity to ARF5 and with very little affinity to ARF6. Interacts with ARL1. Interacts with ATG9A. Golgi apparatus Golgi apparatus, trans-Golgi network membrane Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=G5E8V9-1; Sequence=Displayed; Name=2; IsoId=G5E8V9-2; Sequence=VSP_061208; Name=3; IsoId=G5E8V9-3; Sequence=VSP_061209; Phosphorylated by PRKD1; phosphorylation delocalizes ARFIP1 from the Golgi and disrupts its ability to inhibit the activity of ADP- ribosylation factor, an important component of the vesicle scission machinery. Golgi membrane phospholipid binding cytoplasm cytosol intracellular protein transport protein domain specific binding trans-Golgi network membrane regulation of protein secretion phosphatidylinositol-4-phosphate binding uc008pqe.1 uc008pqe.2 uc008pqe.3 uc008pqe.4 
ENSMUST00000143522.9 Lipo4 ENSMUST00000143522.9 lipase, member O4 (from RefSeq NM_001323386.1) ENSMUST00000143522.1 ENSMUST00000143522.2 ENSMUST00000143522.3 ENSMUST00000143522.4 ENSMUST00000143522.5 ENSMUST00000143522.6 ENSMUST00000143522.7 ENSMUST00000143522.8 F6RR30 F6RR30_MOUSE Lipo4 NM_001323386 uc289rro.1 uc289rro.2 uc289rro.3 Belongs to the AB hydrolase superfamily. Lipase family. sterol esterase activity lipid metabolic process lipid catabolic process sterol metabolic process hydrolase activity hydrolase activity, acting on ester bonds intracellular membrane-bounded organelle uc289rro.1 uc289rro.2 uc289rro.3 
ENSMUST00000143525.2 Gm13963 ENSMUST00000143525.2 Gm13963 (from geneSymbol) ENSMUST00000143525.1 uc289zik.1 uc289zik.2 uc289zik.1 uc289zik.2 
ENSMUST00000143564.8 5830418P13Rik ENSMUST00000143564.8 RIKEN cDNA 5830418P13 gene (from RefSeq NR_040466.1) ENSMUST00000143564.1 ENSMUST00000143564.2 ENSMUST00000143564.3 ENSMUST00000143564.4 ENSMUST00000143564.5 ENSMUST00000143564.6 ENSMUST00000143564.7 NR_040466 uc009rgt.1 uc009rgt.2 uc009rgt.1 uc009rgt.2 
ENSMUST00000143567.8 Atp2b4 ENSMUST00000143567.8 ATPase, Ca++ transporting, plasma membrane 4, transcript variant b (from RefSeq NM_213616.5) AT2B4_MOUSE Atp2b4 ENSMUST00000143567.1 ENSMUST00000143567.2 ENSMUST00000143567.3 ENSMUST00000143567.4 ENSMUST00000143567.5 ENSMUST00000143567.6 ENSMUST00000143567.7 NM_213616 Q32ME1 Q6Q477 uc007cqv.1 uc007cqv.2 uc007cqv.3 uc007cqv.4 uc007cqv.5 Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (By similarity). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (PubMed:15078889). Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.10; Evidence=; Activated by calcium/calmodulin. Interacts with PDZD11. Interacts with SLC35G1 and STIM1. Interacts with calmodulin. Membrane ; Multi- pass membrane protein Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PMCA4b; IsoId=Q6Q477-1; Sequence=Displayed; Name=2; IsoId=Q6Q477-2; Sequence=VSP_058018, VSP_058019; Specifically expressed by sperm in testis (at protein level). Male mice lacking Atp2b4 are infertile with severe reduction of sperm motility. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. nucleotide binding neural retina development calcium-transporting ATPase activity protein binding calmodulin binding ATP binding plasma membrane integral component of plasma membrane cilium regulation of transcription from RNA polymerase II promoter ion transport calcium ion transport cellular calcium ion homeostasis spermatogenesis negative regulation of nitric oxide mediated signal transduction urinary bladder smooth muscle contraction membrane integral component of membrane basolateral plasma membrane protein kinase binding hippocampus development Z disc PDZ domain binding T-tubule flagellated sperm motility protein phosphatase 2B binding motile cilium positive regulation of peptidyl-serine phosphorylation sperm flagellum nitric-oxide synthase inhibitor activity sarcolemma cell projection neuron projection negative regulation of nitric oxide biosynthetic process metal ion binding nitric-oxide synthase binding negative regulation of nitric-oxide synthase activity regulation of cytosolic calcium ion concentration response to hydrostatic pressure calcium ion transmembrane transport negative regulation of calcineurin-NFAT signaling cascade cellular response to epinephrine stimulus sperm principal piece negative regulation of the force of heart contraction glutamatergic synapse integral component of presynaptic active zone membrane negative regulation of arginine catabolic process calcium ion export regulation of cell cycle G1/S phase transition negative regulation of cardiac muscle hypertrophy in response to stress negative regulation of citrulline biosynthetic process cellular response to acetylcholine positive regulation of cAMP-dependent protein kinase activity uc007cqv.1 uc007cqv.2 uc007cqv.3 uc007cqv.4 uc007cqv.5 
ENSMUST00000143569.3 Gm11523 ENSMUST00000143569.3 Gm11523 (from geneSymbol) ENSMUST00000143569.1 ENSMUST00000143569.2 uc288bsh.1 uc288bsh.2 uc288bsh.3 uc288bsh.1 uc288bsh.2 uc288bsh.3 
ENSMUST00000143574.3 1700042G15Rik ENSMUST00000143574.3 RIKEN cDNA 1700042G15 gene, transcript variant 1 (from RefSeq NR_038178.1) ENSMUST00000143574.1 ENSMUST00000143574.2 NR_038178 uc008sye.1 uc008sye.2 uc008sye.3 uc008sye.4 uc008sye.5 uc008sye.1 uc008sye.2 uc008sye.3 uc008sye.4 uc008sye.5 
ENSMUST00000143618.3 Gm11211 ENSMUST00000143618.3 predicted gene 11211 (from RefSeq NR_166522.1) ENSMUST00000143618.1 ENSMUST00000143618.2 NR_166522 uc290nds.1 uc290nds.2 uc290nds.3 uc290nds.1 uc290nds.2 uc290nds.3 
ENSMUST00000143622.2 Gm14951 ENSMUST00000143622.2 Gm14951 (from geneSymbol) ENSMUST00000143622.1 KY468260 uc292qik.1 uc292qik.2 uc292qik.1 uc292qik.2 
ENSMUST00000143638.2 Gm15346 ENSMUST00000143638.2 predicted gene 15346 (from RefSeq NR_188745.1) ENSMUST00000143638.1 NR_188745 uc009ldr.1 uc009ldr.2 uc009ldr.3 uc009ldr.1 uc009ldr.2 uc009ldr.3 
ENSMUST00000143643.3 Gm12055 ENSMUST00000143643.3 Gm12055 (from geneSymbol) AK078949 ENSMUST00000143643.1 ENSMUST00000143643.2 uc007ieg.1 uc007ieg.2 uc007ieg.3 uc007ieg.1 uc007ieg.2 uc007ieg.3 
ENSMUST00000143645.2 Gm14291 ENSMUST00000143645.2 Gm14291 (from geneSymbol) ENSMUST00000143645.1 uc290csi.1 uc290csi.2 uc290csi.1 uc290csi.2 
ENSMUST00000143649.2 1200007C13Rik ENSMUST00000143649.2 1200007C13Rik (from geneSymbol) AK004627 ENSMUST00000143649.1 uc290ctt.1 uc290ctt.2 uc290ctt.1 uc290ctt.2 
ENSMUST00000143662.8 Niban3 ENSMUST00000143662.8 niban apoptosis regulator 3, transcript variant 1 (from RefSeq NM_001384129.1) D3YZB0 D3YZB0_MOUSE ENSMUST00000143662.1 ENSMUST00000143662.2 ENSMUST00000143662.3 ENSMUST00000143662.4 ENSMUST00000143662.5 ENSMUST00000143662.6 ENSMUST00000143662.7 Fam129c NM_001384129 Niban3 uc012gfv.1 uc012gfv.2 uc012gfv.3 Belongs to the Niban family. molecular_function cellular_component biological_process uc012gfv.1 uc012gfv.2 uc012gfv.3 
ENSMUST00000143663.2 Mroh8 ENSMUST00000143663.2 maestro heat-like repeat family member 8 (from RefSeq NM_001039557.4) 4922505G16Rik E9PYI4 E9PYI4_MOUSE ENSMUST00000143663.1 Mroh8 NM_001039557 uc008nou.1 uc008nou.2 uc008nou.3 uc008nou.4 uc008nou.5 molecular_function cellular_component biological_process uc008nou.1 uc008nou.2 uc008nou.3 uc008nou.4 uc008nou.5 
ENSMUST00000143673.3 Slfnlnc ENSMUST00000143673.3 Slfnlnc (from geneSymbol) AK136560 ENSMUST00000143673.1 ENSMUST00000143673.2 uc011ybf.1 uc011ybf.2 uc011ybf.3 uc011ybf.4 uc011ybf.1 uc011ybf.2 uc011ybf.3 uc011ybf.4 
ENSMUST00000143705.3 Gm12932 ENSMUST00000143705.3 Gm12932 (from geneSymbol) ENSMUST00000143705.1 ENSMUST00000143705.2 uc290pua.1 uc290pua.2 uc290pua.3 uc290pua.1 uc290pua.2 uc290pua.3 
ENSMUST00000143710.2 Gm16214 ENSMUST00000143710.2 predicted gene 16214 (from RefSeq NR_165259.1) ENSMUST00000143710.1 NR_165259 uc292gif.1 uc292gif.2 uc292gif.1 uc292gif.2 
ENSMUST00000143715.4 1700095J03Rik ENSMUST00000143715.4 RIKEN cDNA 1700095J03 gene (from RefSeq NR_152110.1) ENSMUST00000143715.1 ENSMUST00000143715.2 ENSMUST00000143715.3 NR_152110 uc009jdo.1 uc009jdo.2 uc009jdo.3 uc009jdo.4 uc009jdo.5 uc009jdo.1 uc009jdo.2 uc009jdo.3 uc009jdo.4 uc009jdo.5 
ENSMUST00000143732.8 F830208F22Rik ENSMUST00000143732.8 F830208F22Rik (from geneSymbol) AK156688 ENSMUST00000143732.1 ENSMUST00000143732.2 ENSMUST00000143732.3 ENSMUST00000143732.4 ENSMUST00000143732.5 ENSMUST00000143732.6 ENSMUST00000143732.7 uc008frx.1 uc008frx.2 uc008frx.3 uc008frx.1 uc008frx.2 uc008frx.3 
ENSMUST00000143750.4 Or1e1d-ps1 ENSMUST00000143750.4 Or1e1d-ps1 (from geneSymbol) ENSMUST00000143750.1 ENSMUST00000143750.2 ENSMUST00000143750.3 uc288aam.1 uc288aam.2 uc288aam.1 uc288aam.2 
ENSMUST00000143764.9 Fsip2 ENSMUST00000143764.9 fibrous sheath-interacting protein 2 (from RefSeq NM_001370266.1) A2ARZ1 A2ARZ3 ENSMUST00000143764.1 ENSMUST00000143764.2 ENSMUST00000143764.3 ENSMUST00000143764.4 ENSMUST00000143764.5 ENSMUST00000143764.6 ENSMUST00000143764.7 ENSMUST00000143764.8 FSIP2_MOUSE NM_001370266 uc289xit.1 uc289xit.2 Plays a role in spermatogenesis. May interact with AKAP4. Predominantly expressed in testis. First detected in testis of 16 day old mice. Sequence=CAM17862.3; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM17864.1; Type=Erroneous gene model prediction; Evidence=; protein binding mitochondrion biological_process motile cilium uc289xit.1 uc289xit.2 
ENSMUST00000143765.2 Gm15884 ENSMUST00000143765.2 Gm15884 (from geneSymbol) ENSMUST00000143765.1 uc291iub.1 uc291iub.2 uc291iub.1 uc291iub.2 
ENSMUST00000143781.2 Cep112it ENSMUST00000143781.2 Cep112it (from geneSymbol) AK081340 ENSMUST00000143781.1 uc288ddy.1 uc288ddy.2 uc288ddy.1 uc288ddy.2 
ENSMUST00000143787.3 9630028B13Rik ENSMUST00000143787.3 RIKEN cDNA 9630028B13 gene (from RefSeq NR_038006.1) ENSMUST00000143787.1 ENSMUST00000143787.2 NR_038006 uc007dzi.1 uc007dzi.2 uc007dzi.3 uc007dzi.4 uc007dzi.5 uc007dzi.6 uc007dzi.7 uc007dzi.1 uc007dzi.2 uc007dzi.3 uc007dzi.4 uc007dzi.5 uc007dzi.6 uc007dzi.7 
ENSMUST00000143789.5 Gm21981 ENSMUST00000143789.5 Gm21981 (from geneSymbol) BC021590 D3Z6Q6 D3Z6Q6_MOUSE ENSMUST00000143789.1 ENSMUST00000143789.2 ENSMUST00000143789.3 ENSMUST00000143789.4 Gm21981 Prickle4 uc289lqu.1 uc289lqu.2 stress fiber actin binding cell-cell adherens junction heart development zinc ion binding Z disc actin cytoskeleton organization filamentous actin metal ion binding muscle alpha-actinin binding muscle structure development uc289lqu.1 uc289lqu.2 
ENSMUST00000143791.8 Bicc1 ENSMUST00000143791.8 BicC family RNA binding protein 1, transcript variant 1 (from RefSeq NM_031397.3) BICC1_MOUSE ENSMUST00000143791.1 ENSMUST00000143791.2 ENSMUST00000143791.3 ENSMUST00000143791.4 ENSMUST00000143791.5 ENSMUST00000143791.6 ENSMUST00000143791.7 NM_031397 Q6P6K3 Q8C286 Q99MQ1 uc007fog.1 uc007fog.2 uc007fog.3 uc007fog.4 uc007fog.5 Putative RNA-binding protein. May be involved in regulating gene expression during embryonic development. Interacts (via KH domains) with ANKS6 (via SAM domain) in an RNA-dependent manner. Interacts with ANKS3 (PubMed:25671767). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99MQ1-1; Sequence=Displayed; Name=2; IsoId=Q99MQ1-2; Sequence=VSP_021950, VSP_021951; In the adult, predominantly expressed in heart and kidney. In 8 week old mice, expressed in growing primary oocytes and in the stromal cells of the theca. In the developing embryo, first detected at the rostral tip of the primitive streak, Hensen's node, at the late streak stage. At the late headfold stage, expression demarcates the layer of the node from which definitive endoderm and midline mesoderm arises. At 6-8 somite stage observed in the definitive endoderm. Strong expression is detected in the caudal intestinal portal. At 12-15 somite stage is still present in the hindgut, but transient expression is also seen in tissues of neural and mesodermal origins. At 13 dpc present around all sites of cartilage formation, such as cervical vertebral bodies, ribs and Merckel's cartilage. Additionally, expressed in the derivatives of the pleuroperitoneal membrane, the diaphragm and the pericardium, as well as the mesenchyme of the developing lung. Expressed in both the mesonephros and metanephros. Belongs to the BicC family. nucleic acid binding RNA binding protein binding cytoplasm multicellular organism development determination of left/right symmetry heart development negative regulation of canonical Wnt signaling pathway uc007fog.1 uc007fog.2 uc007fog.3 uc007fog.4 uc007fog.5 
ENSMUST00000143796.2 Gm11228 ENSMUST00000143796.2 Gm11228 (from geneSymbol) AK083154 ENSMUST00000143796.1 uc290ngo.1 uc290ngo.2 uc290ngo.1 uc290ngo.2 
ENSMUST00000143801.2 Gm12868 ENSMUST00000143801.2 Gm12868 (from geneSymbol) ENSMUST00000143801.1 uc290pjo.1 uc290pjo.2 uc290pjo.1 uc290pjo.2 
ENSMUST00000143812.3 Zfp85os ENSMUST00000143812.3 zinc finger protein 85, opposite strand (from RefSeq NR_027969.1) ENSMUST00000143812.1 ENSMUST00000143812.2 NR_027969 uc011zbk.1 uc011zbk.2 uc011zbk.3 uc011zbk.4 uc011zbk.1 uc011zbk.2 uc011zbk.3 uc011zbk.4 
ENSMUST00000143819.2 Brip1os ENSMUST00000143819.2 BRCA1 interacting protein C-terminal helicase 1, opposite strand, transcript variant 2 (from RefSeq NR_130959.1) ENSMUST00000143819.1 NR_130959 uc007ksh.1 uc007ksh.2 uc007ksh.3 uc007ksh.4 uc007ksh.1 uc007ksh.2 uc007ksh.3 uc007ksh.4 
ENSMUST00000143821.4 A430018G15Rik ENSMUST00000143821.4 RIKEN cDNA A430018G15 gene, transcript variant 2 (from RefSeq NR_165461.1) ENSMUST00000143821.1 ENSMUST00000143821.2 ENSMUST00000143821.3 NR_165461 uc008jqz.1 uc008jqz.2 uc008jqz.3 uc008jqz.4 uc008jqz.5 uc008jqz.1 uc008jqz.2 uc008jqz.3 uc008jqz.4 uc008jqz.5 
ENSMUST00000143842.2 Gpatch8 ENSMUST00000143842.2 G patch domain containing 8 (from RefSeq NM_001159492.1) A2A6A1 ENSMUST00000143842.1 GPTC8_MOUSE Gpatc8 Kiaa0553 NM_001159492 Q80TY1 uc011yfs.1 uc011yfs.2 uc011yfs.3 uc011yfs.4 nucleic acid binding protein binding biological_process metal ion binding uc011yfs.1 uc011yfs.2 uc011yfs.3 uc011yfs.4 
ENSMUST00000143850.8 Derl2 ENSMUST00000143850.8 Der1-like domain family, member 2, transcript variant 1 (from RefSeq NM_033562.4) DERL2_MOUSE Der2 Derl2 ENSMUST00000143850.1 ENSMUST00000143850.2 ENSMUST00000143850.3 ENSMUST00000143850.4 ENSMUST00000143850.5 ENSMUST00000143850.6 ENSMUST00000143850.7 Flana NM_033562 Q8BNI4 Q920I5 Q99J12 uc007jxj.1 uc007jxj.2 uc007jxj.3 uc007jxj.4 Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Forms homo- and heterooligomers with DERL3 and, to a lesser extent, with DERL1 (By similarity). Interacts with the SEL1L/SYVN1 and VCP/SELENOS protein complexes (PubMed:22016385). Mediates association between VCP and EDEM1, as well as that between VCP and the misfolded glycoproteins (By similarity). Interacts with OS9 (By similarity). Interacts with SELENOK and SELENOS (PubMed:22016385). Interacts with the signal recognition particle/SRP and the SRP receptor; in the process of endoplasmic reticulum stress-induced pre-emptive quality control (By similarity). Interacts with CCDC47 (PubMed:25009997). Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BNI4-1; Sequence=Displayed; Name=2; IsoId=Q8BNI4-2; Sequence=VSP_011085; Widely expressed, with lowest levels in brain and heart. Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR). Belongs to the derlin family. Hrd1p ubiquitin ligase ERAD-L complex suckling behavior protein binding early endosome late endosome endoplasmic reticulum signal recognition particle receptor complex endoplasmic reticulum membrane response to unfolded protein positive regulation of cell proliferation membrane integral component of membrane integral component of endoplasmic reticulum membrane positive regulation of cell growth ER-associated ubiquitin-dependent protein catabolic process endoplasmic reticulum unfolded protein response retrograde protein transport, ER to cytosol signal recognition particle misfolded protein binding negative regulation of retrograde protein transport, ER to cytosol ubiquitin-specific protease binding uc007jxj.1 uc007jxj.2 uc007jxj.3 uc007jxj.4 
ENSMUST00000143870.3 Gm13490 ENSMUST00000143870.3 predicted gene 13490 (from RefSeq NR_040639.1) ENSMUST00000143870.1 ENSMUST00000143870.2 NR_040639 uc029txh.1 uc029txh.2 uc029txh.3 uc029txh.1 uc029txh.2 uc029txh.3 
ENSMUST00000143888.2 Gm13133 ENSMUST00000143888.2 predicted gene 13133 (from RefSeq NR_151634.1) ENSMUST00000143888.1 NR_151634 uc290sil.1 uc290sil.2 uc290sil.1 uc290sil.2 
ENSMUST00000143898.2 Gm13652 ENSMUST00000143898.2 Gm13652 (from geneSymbol) AK050902 ENSMUST00000143898.1 uc289xbl.1 uc289xbl.2 uc289xbl.1 uc289xbl.2 
ENSMUST00000143914.8 Zpld1 ENSMUST00000143914.8 Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ. (from UniProt Q8BGZ8) AK034628 ENSMUST00000143914.1 ENSMUST00000143914.2 ENSMUST00000143914.3 ENSMUST00000143914.4 ENSMUST00000143914.5 ENSMUST00000143914.6 ENSMUST00000143914.7 Q14BA1 Q8BGZ8 ZPLD1_MOUSE uc289fau.1 uc289fau.2 Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ. [Zona pellucida-like domain-containing protein 1]: Cytoplasmic vesicle membrane ; Single-pass type I membrane protein [Zona pellucida-like domain-containing protein 1, secreted form]: Secreted, extracellular space, extracellular matrix Proteolytically cleaved before the transmembrane segment to yield the secreted form found in the extracellular matrix of the cupula. molecular_function extracellular region biological_process membrane integral component of membrane cytoplasmic vesicle membrane cytoplasmic vesicle uc289fau.1 uc289fau.2 
ENSMUST00000143917.2 Rdh18-ps ENSMUST00000143917.2 retinol dehydrogenase 18, pseudogene (from RefSeq NR_037604.1) ENSMUST00000143917.1 NR_037604 uc007hks.1 uc007hks.2 uc007hks.3 uc007hks.4 uc007hks.1 uc007hks.2 uc007hks.3 uc007hks.4 
ENSMUST00000143922.2 Gm4846 ENSMUST00000143922.2 predicted gene 4846 (from RefSeq NM_001164306.1) B2RWH8 B2RWH8_MOUSE EG226601 ENSMUST00000143922.1 Gm4846 NM_001164306 uc011wvl.1 uc011wvl.2 Reaction=(2E)-geranial + H(+) + NADPH + O2 = (1E)-2,6- dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+); Xref=Rhea:RHEA:54860, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:138375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54861; Evidence=; Reaction=H(+) + NADPH + O2 + octan-3-one = H2O + NADP(+) + pentyl propanoate; Xref=Rhea:RHEA:54840, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:80946, ChEBI:CHEBI:87373; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54841; Evidence=; Reaction=H(+) + NADPH + O2 + octan-3-one = ethyl hexanoate + H2O + NADP(+); Xref=Rhea:RHEA:54856, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:80946, ChEBI:CHEBI:86055; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54857; Evidence=; Reaction=H(+) + NADPH + O2 + sulcatone = 4-methylpent-3-en-1-yl acetate + H2O + NADP(+); Xref=Rhea:RHEA:54864, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16310, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:138373; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54865; Evidence=; Reaction=H(+) + NADPH + O2 = H2O2 + NADP(+); Xref=Rhea:RHEA:11260, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.6.3.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11261; Evidence=; Reaction=H(+) + heptan-2-one + NADPH + O2 = H2O + NADP(+) + pentyl acetate; Xref=Rhea:RHEA:54836, ChEBI:CHEBI:5672, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:87362; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54837; Evidence=; Reaction=H(+) + heptan-4-one + NADPH + O2 = H2O + NADP(+) + propyl butanoate; Xref=Rhea:RHEA:54852, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:89484, ChEBI:CHEBI:89719; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54853; Evidence=; Reaction=H(+) + hexan-3-one + NADPH + O2 = H2O + NADP(+) + propyl propanoate; Xref=Rhea:RHEA:54848, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:89828, ChEBI:CHEBI:89891; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54849; Evidence=; Reaction=H(+) + hexan-3-one + NADPH + O2 = ethyl butanoate + H2O + NADP(+); Xref=Rhea:RHEA:54844, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88764, ChEBI:CHEBI:89891; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54845; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Endoplasmic reticulum membrane Membrane Microsome membrane Belongs to the FMO family. monooxygenase activity N,N-dimethylaniline monooxygenase activity cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane oxidoreductase activity organelle membrane intracellular membrane-bounded organelle flavin adenine dinucleotide binding NADP binding oxidation-reduction process uc011wvl.1 uc011wvl.2 
ENSMUST00000143935.3 Or4a70 ENSMUST00000143935.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGM6) ENSMUST00000143935.1 ENSMUST00000143935.2 Olfr1242 Or4a70 Q8VGM6 Q8VGM6_MOUSE uc289ycr.1 uc289ycr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ycr.1 uc289ycr.2 
ENSMUST00000143949.2 4921518K17Rik ENSMUST00000143949.2 RIKEN cDNA 4921518K17 gene (from RefSeq NR_131110.1) ENSMUST00000143949.1 NR_131110 uc056yqp.1 uc056yqp.2 uc056yqp.1 uc056yqp.2 
ENSMUST00000143962.3 Frs3os ENSMUST00000143962.3 Frs3os (from geneSymbol) AK076701 ENSMUST00000143962.1 ENSMUST00000143962.2 uc029tih.1 uc029tih.2 uc029tih.3 uc029tih.4 uc029tih.1 uc029tih.2 uc029tih.3 uc029tih.4 
ENSMUST00000143967.3 Gm12973 ENSMUST00000143967.3 Gm12973 (from geneSymbol) ENSMUST00000143967.1 ENSMUST00000143967.2 uc290qhy.1 uc290qhy.2 uc290qhy.3 uc290qhy.1 uc290qhy.2 uc290qhy.3 
ENSMUST00000143971.2 Micos10 ENSMUST00000143971.2 mitochondrial contact site and cristae organizing system subunit 10, transcript variant 2 (from RefSeq NR_033745.1) A2ALL2 ENSMUST00000143971.1 MIC10_MOUSE Mic10 Minos1 NR_033745 Q3U6N5 Q7TNS2 uc008vlu.1 uc008vlu.2 uc008vlu.3 Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13 (By similarity). This complex was also known under the names MINOS or MitOS complex (By similarity). The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (By similarity). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with IMMT/MIC60 and MICOS13/MIC13 (By similarity). Interacts with APOO/MIC23/MIC26 and APOOL/MIC27 (By similarity). Interacts with ARMC1 (By similarity). Mitochondrion inner membrane ; Single-pass membrane protein Note=The C-terminus is located in the intermembrane space, while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space. Belongs to the MICOS complex subunit Mic10 family. molecular_function mitochondrion mitochondrial inner membrane biological_process membrane integral component of membrane MICOS complex uc008vlu.1 uc008vlu.2 uc008vlu.3 
ENSMUST00000143974.2 Cerkl ENSMUST00000143974.2 ceramide kinase-like (from RefSeq NM_001048176.1) A2AQH1 A2AQH1_MOUSE Cerkl ENSMUST00000143974.1 NM_001048176 uc008kgs.1 uc008kgs.2 uc008kgs.3 photoreceptor outer segment photoreceptor inner segment NAD+ kinase activity nucleus nucleolus cytoplasm endoplasmic reticulum Golgi apparatus cytosol kinase activity phosphorylation sphingolipid biosynthetic process negative regulation of apoptotic process sphingolipid binding lipid phosphorylation perinuclear region of cytoplasm ceramide kinase activity uc008kgs.1 uc008kgs.2 uc008kgs.3 
ENSMUST00000143987.9 Ndufv2 ENSMUST00000143987.9 NADH:ubiquinone oxidoreductase core subunit V2, transcript variant 1 (from RefSeq NM_028388.3) ENSMUST00000143987.1 ENSMUST00000143987.2 ENSMUST00000143987.3 ENSMUST00000143987.4 ENSMUST00000143987.5 ENSMUST00000143987.6 ENSMUST00000143987.7 ENSMUST00000143987.8 NDUV2_MOUSE NM_028388 Ndufv2 Q3U9L9 Q8BU07 Q8K2L0 Q9D6J6 uc008dgw.1 uc008dgw.2 uc008dgw.3 uc008dgw.4 This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The bovine ortholog of this protein has been characterized and is reported to contain an iron-sulfur cluster, which may be involved in electron transfer. In humans mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]. Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains one iron-sulfur cluster. Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29092; Evidence=; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 1 [2Fe-2S] cluster. ; Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D6J6-1; Sequence=Displayed; Name=2; IsoId=Q9D6J6-2; Sequence=VSP_025017; Belongs to the complex I 24 kDa subunit family. NADH dehydrogenase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial electron transport, NADH to ubiquinone nervous system development NADH dehydrogenase (ubiquinone) activity membrane oxidoreductase activity myelin sheath metal ion binding cardiac muscle tissue development iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding oxidation-reduction process respiratory chain uc008dgw.1 uc008dgw.2 uc008dgw.3 uc008dgw.4 
ENSMUST00000143999.9 Firre ENSMUST00000143999.9 Firre (from geneSymbol) ENSMUST00000143999.1 ENSMUST00000143999.2 ENSMUST00000143999.3 ENSMUST00000143999.4 ENSMUST00000143999.5 ENSMUST00000143999.6 ENSMUST00000143999.7 ENSMUST00000143999.8 KJ638686 uc292ock.1 uc292ock.2 uc292ock.3 uc292ock.1 uc292ock.2 uc292ock.3 
ENSMUST00000144020.9 Kcnmb4os2 ENSMUST00000144020.9 potassium large conductance calcium-activated channel, subfamily M, beta member 4, opposite strand 2 (from RefSeq NR_130644.1) ENSMUST00000144020.1 ENSMUST00000144020.2 ENSMUST00000144020.3 ENSMUST00000144020.4 ENSMUST00000144020.5 ENSMUST00000144020.6 ENSMUST00000144020.7 ENSMUST00000144020.8 NR_130644 uc007hbz.1 uc007hbz.2 uc007hbz.3 uc007hbz.4 uc007hbz.5 uc007hbz.6 uc007hbz.1 uc007hbz.2 uc007hbz.3 uc007hbz.4 uc007hbz.5 uc007hbz.6 
ENSMUST00000144024.2 Gm12147 ENSMUST00000144024.2 Gm12147 (from geneSymbol) ENSMUST00000144024.1 uc287xmt.1 uc287xmt.2 uc287xmt.1 uc287xmt.2 
ENSMUST00000144026.3 Sox5it ENSMUST00000144026.3 Sox5it (from geneSymbol) AK016013 ENSMUST00000144026.1 ENSMUST00000144026.2 uc291kdc.1 uc291kdc.2 uc291kdc.3 uc291kdc.1 uc291kdc.2 uc291kdc.3 
ENSMUST00000144031.4 Gm13201 ENSMUST00000144031.4 Gm13201 (from geneSymbol) ENSMUST00000144031.1 ENSMUST00000144031.2 ENSMUST00000144031.3 uc290rtz.1 uc290rtz.2 uc290rtz.3 uc290rtz.1 uc290rtz.2 uc290rtz.3 
ENSMUST00000144039.2 4930509K18Rik ENSMUST00000144039.2 RIKEN cDNA 4930509K18 gene (from RefSeq NR_040663.1) ENSMUST00000144039.1 NR_040663 uc029uqb.1 uc029uqb.2 uc029uqb.1 uc029uqb.2 
ENSMUST00000144043.2 Gm13943 ENSMUST00000144043.2 Gm13943 (from geneSymbol) ENSMUST00000144043.1 uc289xfa.1 uc289xfa.2 uc289xfa.1 uc289xfa.2 
ENSMUST00000144085.5 Gm21814 ENSMUST00000144085.5 Gm21814 (from geneSymbol) AK168915 ENSMUST00000144085.1 ENSMUST00000144085.2 ENSMUST00000144085.3 ENSMUST00000144085.4 uc291kmz.1 uc291kmz.2 uc291kmz.3 uc291kmz.4 uc291kmz.1 uc291kmz.2 uc291kmz.3 uc291kmz.4 
ENSMUST00000144096.2 Gm11755 ENSMUST00000144096.2 Gm11755 (from geneSymbol) ENSMUST00000144096.1 KY467621 uc288eae.1 uc288eae.2 uc288eae.1 uc288eae.2 
ENSMUST00000144098.2 Samt1c ENSMUST00000144098.2 spermatogenesis associated multipass transmembrane protein 1c (from RefSeq NM_001243016.1) 4921511M17Rik A2BED8 A2BED8_MOUSE ENSMUST00000144098.1 Gm10057 Gm5645 NM_001243016 Samt1 Samt1b Samt1c uc009urf.1 uc009urf.2 uc009urf.3 uc009urf.4 molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc009urf.1 uc009urf.2 uc009urf.3 uc009urf.4 
ENSMUST00000144099.8 Cdk5rap2 ENSMUST00000144099.8 CDK5 regulatory subunit associated protein 2, transcript variant 1 (from RefSeq NM_145990.4) A2AVA1 CK5P2_MOUSE ENSMUST00000144099.1 ENSMUST00000144099.2 ENSMUST00000144099.3 ENSMUST00000144099.4 ENSMUST00000144099.5 ENSMUST00000144099.6 ENSMUST00000144099.7 Kiaa1633 NM_145990 Q6PCN1 Q6ZPL0 Q8K389 uc008thy.1 uc008thy.2 uc008thy.3 uc008thy.4 Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion (PubMed:20627074). Involved in regulation of mitotic spindle orientation (PubMed:20460369). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Required for the recruitment of AKAP9 to centrosomes (By similarity). Plays a role in neurogenesis (PubMed:20471352). Contrary to higher mammalian orthologs, including human, chimpanzee, bovine and dog, does not interact with EB1/MAPRE1, therefore its function in the regulation of microtubule dynamics is unclear (PubMed:19553473). Interacts with CDK5R1 (p35 form) (By similarity). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. May form a complex with CDK5R1 and CDK5 (By similarity). Interacts (via C- terminus) with PCNT; the interaction is leading to centrosomal localization of CDK5RAP2 and PCNT. Interacts with AKAP9; the interaction is leading to Golgi localization of CDK5RAP2 and AKAP9 (By similarity). Interacts with TUBG1; the interaction is leading to the centrosomal localization of CDK5RAP2 and TUBG1 (By similarity). Interacts with TUBGCP3 (By similarity). Interacts with CALM1 (By similarity). Interacts with CDC20 (By similarity). Interacts with CEP68; degradation of CEP68 in early mitosis leads to removal of CDK5RAP2 from the centrosome which promotes centriole disengagement and subsequent centriole separation (By similarity). Interacts with NCKAP5L (By similarity). Interacts with LGALS3BP; this interaction may connect the pericentrosomal complex to the gamma-tubulin ring complex (gamma- TuRC) to promote microtubule assembly and acetylation (By similarity). Contrary to human, chimpanzee, bovine and dog orthologous proteins, does not interact with EB1/MAPRE1, possibly due to a divergence at the level of the critical residue 940, which is a proline in MAPRE1-binding orthologs and a leucine in mouse and rat (PubMed:19553473). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome lgi apparatus Cytoplasm Note=Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Due to the lack of interaction with EB1/MAPRE1, its localization to microtubule plus ends may not be conserved in mice (Probable). Localization to centrosomes versus Golgi apparatus may be cell type-dependent (By similarity). Expressed in testis, thymus, heart and brain. Detected in the developing cortex at 9.5 dpc. Expression peaks between 10.5 and 13.5 dpc, remains robust at 15.5 dpc and declines thereafter. This peak corresponds to periods of active neurogenesis. Phosphorylated in vitro by CDK5. Sequence=BAC98221.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; establishment of mitotic spindle orientation microtubule cytoskeleton organization pericentriolar material spindle pole microtubule bundle formation protein binding calmodulin binding cytoplasm Golgi apparatus centrosome microtubule organizing center cytoskeleton microtubule chromosome segregation centrosome cycle centriole replication brain development microtubule binding gamma-tubulin ring complex tubulin binding protein kinase binding neurogenesis cell junction microtubule organizing center organization positive regulation of microtubule polymerization microtubule plus-end gamma-tubulin binding transcription regulatory region DNA binding macromolecular complex binding negative regulation of neuron differentiation positive regulation of transcription, DNA-templated negative regulation of centriole replication perinuclear region of cytoplasm regulation of mitotic cell cycle spindle assembly checkpoint mitotic spindle pole uc008thy.1 uc008thy.2 uc008thy.3 uc008thy.4 
ENSMUST00000144105.2 4930466I24Rik ENSMUST00000144105.2 4930466I24Rik (from geneSymbol) AK015514 ENSMUST00000144105.1 uc291het.1 uc291het.2 uc291het.1 uc291het.2 
ENSMUST00000144161.2 ENSMUSG00000121717 ENSMUST00000144161.2 ENSMUSG00000121717 (from geneSymbol) AK082178 ENSMUST00000144161.1 uc012hbf.1 uc012hbf.2 uc012hbf.3 uc012hbf.4 uc012hbf.1 uc012hbf.2 uc012hbf.3 uc012hbf.4 
ENSMUST00000144164.9 Lyrm7 ENSMUST00000144164.9 LYR motif containing 7, transcript variant 1 (from RefSeq NM_029327.5) B7ZDF8 ENSMUST00000144164.1 ENSMUST00000144164.2 ENSMUST00000144164.3 ENSMUST00000144164.4 ENSMUST00000144164.5 ENSMUST00000144164.6 ENSMUST00000144164.7 ENSMUST00000144164.8 LYRM7_MOUSE MZM1L NM_029327 Q9DA03 uc011xuy.1 uc011xuy.2 uc011xuy.3 uc011xuy.4 Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity). Interacts with UQCRFS1. Mitochondrion matrix Belongs to the complex I LYR family. Sequence=BAB24512.1; Type=Erroneous initiation; Evidence=; molecular_function mitochondrion mitochondrial matrix mitochondrial membrane mitochondrial respiratory chain complex III assembly cellular respiration uc011xuy.1 uc011xuy.2 uc011xuy.3 uc011xuy.4 
ENSMUST00000144177.8 Adhfe1 ENSMUST00000144177.8 alcohol dehydrogenase, iron containing, 1, transcript variant 1 (from RefSeq NM_175236.5) ENSMUST00000144177.1 ENSMUST00000144177.2 ENSMUST00000144177.3 ENSMUST00000144177.4 ENSMUST00000144177.5 ENSMUST00000144177.6 ENSMUST00000144177.7 HOT_MOUSE NM_175236 Q78SV3 Q8BYP0 Q8R0N6 uc007agl.1 uc007agl.2 uc007agl.3 uc007agl.4 Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity). Reaction=(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2- hydroxyglutarate + acetoacetate; Xref=Rhea:RHEA:23048, ChEBI:CHEBI:11047, ChEBI:CHEBI:13705, ChEBI:CHEBI:15801, ChEBI:CHEBI:16810; EC=1.1.99.24; Reaction=2-oxoglutarate + 4-hydroxybutanoate = (R)-2-hydroxyglutarate + succinate semialdehyde; Xref=Rhea:RHEA:24734, ChEBI:CHEBI:15801, ChEBI:CHEBI:16724, ChEBI:CHEBI:16810, ChEBI:CHEBI:57706; EC=1.1.99.24; Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R0N6-1; Sequence=Displayed; Name=2; IsoId=Q8R0N6-2; Sequence=VSP_031987; Expressed in white and brown adipose tissues, liver, and kidney. Expression is differentiation-dependent during in vitro brown and white adipogenesis. Down-regulated of 40% in white adipose tissue of ob/ob obese mice. Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. alcohol dehydrogenase (NAD) activity mitochondrion glutamate catabolic process via 2-oxoglutarate oxidoreductase activity metal ion binding hydroxyacid-oxoacid transhydrogenase activity oxidation-reduction process uc007agl.1 uc007agl.2 uc007agl.3 uc007agl.4 
ENSMUST00000144183.3 Zfp85 ENSMUST00000144183.3 zinc finger protein 85 (from RefSeq NM_001001130.3) B8JJY3 ENSMUST00000144183.1 ENSMUST00000144183.2 NM_001001130 Q7TMC9 Q7TMC9_MOUSE Rslcan2 Zfp85 Zfp85-rs1 uc007rbm.1 uc007rbm.2 uc007rbm.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007rbm.1 uc007rbm.2 uc007rbm.3 
ENSMUST00000144211.2 Srrm3 ENSMUST00000144211.2 serine/arginine repetitive matrix 3, transcript variant 2 (from RefSeq NM_021403.3) ENSMUST00000144211.1 MNCb-4760 NM_021403 Q80WV7 Q9CUV5 Q9JJ91 SRRM3_MOUSE uc008zzc.1 uc008zzc.2 May play a role in regulating breast cancer cell invasiveness. May be involved in RYBP-mediated breast cancer progression. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80WV7-1; Sequence=Displayed; Name=2; IsoId=Q80WV7-2; Sequence=VSP_034270, VSP_034271; Belongs to the CWC21 family. Sequence=BAB29002.1; Type=Erroneous initiation; Evidence=; mRNA binding cellular_component biological_process uc008zzc.1 uc008zzc.2 
ENSMUST00000144222.8 Zfp593os ENSMUST00000144222.8 Zfp593os (from geneSymbol) A0A0U1RNU5 A0A0U1RNU5_MOUSE AK087464 E130218I03Rik ENSMUST00000144222.1 ENSMUST00000144222.2 ENSMUST00000144222.3 ENSMUST00000144222.4 ENSMUST00000144222.5 ENSMUST00000144222.6 ENSMUST00000144222.7 Zfp593os uc008vem.1 uc008vem.2 uc008vem.3 membrane integral component of membrane uc008vem.1 uc008vem.2 uc008vem.3 
ENSMUST00000144230.3 Gm11695 ENSMUST00000144230.3 Gm11695 (from geneSymbol) ENSMUST00000144230.1 ENSMUST00000144230.2 uc288dlg.1 uc288dlg.2 uc288dlg.3 uc288dlg.1 uc288dlg.2 uc288dlg.3 
ENSMUST00000144234.8 Slc19a1 ENSMUST00000144234.8 solute carrier family 19 (folate transporter), member 1, transcript variant 2 (from RefSeq NM_001199271.1) ENSMUST00000144234.1 ENSMUST00000144234.2 ENSMUST00000144234.3 ENSMUST00000144234.4 ENSMUST00000144234.5 ENSMUST00000144234.6 ENSMUST00000144234.7 NM_001199271 Q542F3 Q542F3_MOUSE Slc19a1 uc007fvc.1 uc007fvc.2 uc007fvc.3 uc007fvc.4 Transporter that mediates the import of reduced folates. Cell membrane ; Multi-pass membrane protein Apical cell membrane Basolateral cell membrane Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. integral component of plasma membrane reduced folate carrier activity methotrexate transporter activity folic acid transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane vitamin transport methotrexate transport vitamin transmembrane transporter activity folic acid import into cell uc007fvc.1 uc007fvc.2 uc007fvc.3 uc007fvc.4 
ENSMUST00000144258.8 Pkn1 ENSMUST00000144258.8 protein kinase N1, transcript variant 1 (from RefSeq NM_001199593.1) ENSMUST00000144258.1 ENSMUST00000144258.2 ENSMUST00000144258.3 ENSMUST00000144258.4 ENSMUST00000144258.5 ENSMUST00000144258.6 ENSMUST00000144258.7 NM_001199593 P70268 PKN1_MOUSE Pkn Prk1 Prkcl1 Q3UEA6 Q7TST2 Q8BTL8 uc009mkw.1 uc009mkw.2 uc009mkw.3 uc009mkw.4 PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser- 163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=; Kinase activity is activated upon binding to Rho proteins (RHOA, RHOB and RAC1). Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids. Activated by caspase-3 (CASP3) cleavage during apoptosis. Two specific sites, Thr-778 (activation loop of the kinase domain) and Ser-920 (turn motif), need to be phosphorylated for its full activation. Interacts with ZFAND6 (PubMed:11054541). Interacts with ANDR. Interacts with PRKCB. Interacts (via REM 1 and REM 2 repeats) with RAC1 (By similarity). Interacts (via REM 1 repeat) with RHOA (PubMed:8571127). Interacts with RHOB. Interacts (via C-terminus) with PDPK1. Interacts with CCNT2; enhances MYOD1-dependent transcription. Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (By similarity). Cytoplasm Nucleus Endosome Cell membrane ; Peripheral membrane protein Cleavage furrow Midbody Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70268-1; Sequence=Displayed; Name=2; IsoId=P70268-2; Sequence=VSP_039223; The C1 domain does not bind the diacylglycerol (DAG). Autophosphorylated; preferably on serine. Activated by limited proteolysis with trypsin. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. nucleotide binding B cell homeostasis B cell apoptotic process negative regulation of protein phosphorylation regulation of germinal center formation regulation of immunoglobulin production renal system process chromatin binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein kinase C binding protein binding ATP binding nucleus cytoplasm endosome plasma membrane chromatin organization regulation of transcription from RNA polymerase II promoter protein phosphorylation negative regulation of protein kinase activity hyperosmotic response signal transduction epithelial cell migration membrane kinase activity phosphorylation transferase activity GTP-Rho binding peptidyl-serine phosphorylation ligand-dependent nuclear receptor transcription coactivator activity midbody negative regulation of B cell proliferation cytoplasmic vesicle cleavage furrow macromolecular complex histone kinase activity (H3-T11 specific) histone H3-T11 phosphorylation intracellular signal transduction histone binding histone deacetylase binding Rac GTPase binding spleen development androgen receptor binding positive regulation of nucleic acid-templated transcription regulation of cell motility uc009mkw.1 uc009mkw.2 uc009mkw.3 uc009mkw.4 
ENSMUST00000144277.2 Gm11365 ENSMUST00000144277.2 Gm11365 (from geneSymbol) BC042738 ENSMUST00000144277.1 uc288lsh.1 uc288lsh.2 uc288lsh.1 uc288lsh.2 
ENSMUST00000144291.2 Gm15868 ENSMUST00000144291.2 Gm15868 (from geneSymbol) ENSMUST00000144291.1 uc289cps.1 uc289cps.2 uc289cps.1 uc289cps.2 
ENSMUST00000144294.2 Gm14696 ENSMUST00000144294.2 predicted gene 14696 (from RefSeq NR_167731.1) ENSMUST00000144294.1 NR_167731 uc009tda.1 uc009tda.2 uc009tda.3 uc009tda.1 uc009tda.2 uc009tda.3 
ENSMUST00000144326.4 Ranbp9 ENSMUST00000144326.4 RAN binding protein 9, transcript variant 1 (from RefSeq NM_019930.3) E9Q5D6 E9Q5D6_MOUSE ENSMUST00000144326.1 ENSMUST00000144326.2 ENSMUST00000144326.3 NM_019930 Ranbp9 uc011yyu.1 uc011yyu.2 uc011yyu.3 Cytoplasm Nucleus Belongs to the RANBP9/10 family. ubiquitin ligase complex nucleus cytoplasm enzyme binding negative regulation of ERK1 and ERK2 cascade uc011yyu.1 uc011yyu.2 uc011yyu.3 
ENSMUST00000144331.8 Satb1 ENSMUST00000144331.8 special AT-rich sequence binding protein 1, transcript variant 2 (from RefSeq NM_009122.2) ENSMUST00000144331.1 ENSMUST00000144331.2 ENSMUST00000144331.3 ENSMUST00000144331.4 ENSMUST00000144331.5 ENSMUST00000144331.6 ENSMUST00000144331.7 NM_009122 Q60611 Q91XB1 SATB1_MOUSE uc008czf.1 uc008czf.2 uc008czf.3 uc008czf.4 Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin- loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (PubMed:26305964). Interacts with PCAF. Interacts with sumoylated PML and HDAC1 Tat via the ULD domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300 (By similarity). Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least of SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes transcription repression. Interacts with CUX1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA. Nucleus. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs) (By similarity). Expressed in the subventricular zone, rostral migratory stream and in the olfactory bulb (at protein level) (PubMed:26305964). Mainly expressed in thymus, spleen, and lymph nodes with a lower level observed in the brain (PubMed:15814699). Up-regulated during adult neuronal stem cell differentiation. Sumoylated. Sumoylation promotes cleavage by caspases. Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation (By similarity). Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The cleaved forms cannot dimerize and lose transcription regulation function because of impaired DNA and chromatin association. Mice are small in size, have disproportionately small thymi and spleens, and die at 3 weeks of age. Multiple defects in T-cell development are observed, including interrupted thymocytes differentiation and abnormal T-cell transcriptome. RNAi-mediated knockdown in neural stem/progenitor cells in the adult subventricular zone impairs early neuronal differentiation (PubMed:26305964). Belongs to the CUT homeobox family. negative regulation of transcription from RNA polymerase II promoter chromatin RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm nuclear heterochromatin chromatin organization chromatin remodeling regulation of transcription, DNA-templated epidermis development nuclear matrix histone methylation nuclear body PML body T cell activation CD4-positive, alpha-beta T cell differentiation CD8-positive, alpha-beta T cell differentiation activated T cell proliferation reflex uc008czf.1 uc008czf.2 uc008czf.3 uc008czf.4 
ENSMUST00000144339.2 Gm16041 ENSMUST00000144339.2 Gm16041 (from geneSymbol) AK044237 ENSMUST00000144339.1 uc287gfg.1 uc287gfg.2 uc287gfg.1 uc287gfg.2 
ENSMUST00000144347.2 Gm13134 ENSMUST00000144347.2 Gm13134 (from geneSymbol) ENSMUST00000144347.1 uc290sim.1 uc290sim.2 uc290sim.1 uc290sim.2 
ENSMUST00000144350.2 Gm15577 ENSMUST00000144350.2 Gm15577 (from geneSymbol) AK035866 ENSMUST00000144350.1 uc290kuy.1 uc290kuy.2 uc290kuy.1 uc290kuy.2 
ENSMUST00000144368.2 Gm13974 ENSMUST00000144368.2 Gm13974 (from geneSymbol) AK043709 ENSMUST00000144368.1 uc289zjq.1 uc289zjq.2 uc289zjq.1 uc289zjq.2 
ENSMUST00000144382.8 Ppp1r18 ENSMUST00000144382.8 protein phosphatase 1, regulatory subunit 18, transcript variant 3 (from RefSeq NM_001146711.1) B8JJ63 B8JJ64 ENSMUST00000144382.1 ENSMUST00000144382.2 ENSMUST00000144382.3 ENSMUST00000144382.4 ENSMUST00000144382.5 ENSMUST00000144382.6 ENSMUST00000144382.7 NM_001146711 PPR18_MOUSE Q3UDS6 Q8BQ30 Q8CEY9 Q8R3D8 uc012ars.1 uc012ars.2 uc012ars.3 May target protein phosphatase 1 to F-actin cytoskeleton. Interacts with Protein phosphatase 1 (PP1). Cytoplasm, cytoskeleton Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BQ30-1; Sequence=Displayed; Name=2; IsoId=Q8BQ30-2; Sequence=VSP_014260; Sequence=AAH25573.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function actin binding cellular_component cytoplasm cytoskeleton biological_process phosphatase binding uc012ars.1 uc012ars.2 uc012ars.3 
ENSMUST00000144398.2 St6galnac2 ENSMUST00000144398.2 St6galnac2 (from geneSymbol) BC023076 C0J8I2 C0J8I2_MOUSE ENSMUST00000144398.1 St6galnac2 uc288dui.1 uc288dui.2 uc288dui.1 uc288dui.2 
ENSMUST00000144407.2 Gm12898 ENSMUST00000144407.2 Gm12898 (from geneSymbol) ENSMUST00000144407.1 uc290pkb.1 uc290pkb.2 uc290pkb.1 uc290pkb.2 
ENSMUST00000144408.2 Ptgir ENSMUST00000144408.2 prostaglandin I receptor (IP), transcript variant 1 (from RefSeq NM_008967.4) ENSMUST00000144408.1 NM_008967 P43252 PI2R_MOUSE Q52KE5 uc009fim.1 uc009fim.2 uc009fim.3 uc009fim.4 Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Interacts (non-isoprenylated C-terminus) with PDZK1. Cell membrane; Multi-pass membrane protein. Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C. Belongs to the G-protein coupled receptor 1 family. Sequence=BAA05144.1; Type=Erroneous initiation; Evidence=; G-protein coupled receptor activity cytosol plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration negative regulation of platelet-derived growth factor receptor signaling pathway membrane integral component of membrane prostacyclin receptor activity response to lipopolysaccharide negative regulation of smooth muscle cell proliferation uc009fim.1 uc009fim.2 uc009fim.3 uc009fim.4 
ENSMUST00000144412.2 Gm14643 ENSMUST00000144412.2 Gm14643 (from geneSymbol) AK043715 ENSMUST00000144412.1 uc292nwe.1 uc292nwe.2 uc292nwe.1 uc292nwe.2 
ENSMUST00000144419.3 Gm12364 ENSMUST00000144419.3 Gm12364 (from geneSymbol) ENSMUST00000144419.1 ENSMUST00000144419.2 uc290lsz.1 uc290lsz.2 uc290lsz.3 uc290lsz.1 uc290lsz.2 uc290lsz.3 
ENSMUST00000144420.3 Gm16252 ENSMUST00000144420.3 Gm16252 (from geneSymbol) ENSMUST00000144420.1 ENSMUST00000144420.2 KY468230 uc009rgw.1 uc009rgw.2 uc009rgw.3 uc009rgw.4 uc009rgw.1 uc009rgw.2 uc009rgw.3 uc009rgw.4 
ENSMUST00000144458.8 Usp10 ENSMUST00000144458.8 ubiquitin specific peptidase 10, transcript variant 1 (from RefSeq NM_009462.2) ENSMUST00000144458.1 ENSMUST00000144458.2 ENSMUST00000144458.3 ENSMUST00000144458.4 ENSMUST00000144458.5 ENSMUST00000144458.6 ENSMUST00000144458.7 Kiaa0190 NM_009462 Ode-1 P52479 Q3T9L4 Q3TNN5 Q3TZB8 Q3U5E0 Q6ZQG9 Q91VY7 UBP10_MOUSE Uchrp uc009nqn.1 uc009nqn.2 uc009nqn.3 uc009nqn.4 uc009nqn.5 Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34- containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits. Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules. Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome. Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Deubiquitinates TBX21 leading to its stabilization. Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative of MBCQ that binds to USP10 and inhibits deubiquitinase activity. Regulated by PIK3C3/VPS34- containing complexes (By similarity). Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta (IL1B)-mediated NF-kappa-B activation by promoting IKBKG or TRAF6 deubiquitination. Interacts with IKBKG; this interaction increases in response to DNA damage. Interacts with TANK; this interaction increases in response to DNA damage. Interacts with TRAF6; this interaction increases in response to DNA damage. Interacts with ZC3H12A; this interaction increases in response to DNA damage. Interacts with G3BP1 (via NTF2 domain) and G3BP2 (via NTF2 domain); inhibiting stress granule formation. P52479; P10637: Mapt; NbExp=3; IntAct=EBI-8327299, EBI-774043; Cytoplasm Nucleus Early endosome Note=Cytoplasmic in normal conditions (By similarity). After DNA damage, translocates to the nucleus following phosphorylation by ATM (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P52479-1; Sequence=Displayed; Name=2; IsoId=P52479-2; Sequence=VSP_038870; Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus. Ubiquitinated. Deubiquitinated by USP13 (By similarity). Mice with a deficiency in USP10 show more potent resistance to RNA virus infection. Belongs to the peptidase C19 family. USP10 subfamily. Sequence=BAC97893.1; Type=Erroneous initiation; Evidence=; p53 binding cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus nucleoplasm cytoplasm endosome early endosome cytosol DNA repair proteolysis ubiquitin-dependent protein catabolic process autophagy cellular response to DNA damage stimulus peptidase activity cysteine-type peptidase activity regulation of autophagy protein deubiquitination hydrolase activity DNA damage response, signal transduction by p53 class mediator macromolecular complex thiol-dependent ubiquitinyl hydrolase activity negative regulation of I-kappaB kinase/NF-kappaB signaling ion channel binding cellular response to interleukin-1 uc009nqn.1 uc009nqn.2 uc009nqn.3 uc009nqn.4 uc009nqn.5 
ENSMUST00000144487.8 4930426D05Rik ENSMUST00000144487.8 4930426D05Rik (from geneSymbol) AK015205 ENSMUST00000144487.1 ENSMUST00000144487.2 ENSMUST00000144487.3 ENSMUST00000144487.4 ENSMUST00000144487.5 ENSMUST00000144487.6 ENSMUST00000144487.7 uc289oho.1 uc289oho.2 uc289oho.1 uc289oho.2 
ENSMUST00000144531.2 Naa38 ENSMUST00000144531.2 N(alpha)-acetyltransferase 38, NatC auxiliary subunit (from RefSeq NM_030083.2) ENSMUST00000144531.1 LSMD1_MOUSE Lsmd1 NM_030083 Q05BF7 Q9D2U5 uc007jqa.1 uc007jqa.2 uc007jqa.3 Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D2U5-1; Sequence=Displayed; Name=2; IsoId=Q9D2U5-2; Sequence=VSP_027567; Belongs to the snRNP Sm proteins family. molecular_function nucleus cytoplasm polysome NatC complex negative regulation of apoptotic process uc007jqa.1 uc007jqa.2 uc007jqa.3 
ENSMUST00000144541.3 Gm11376 ENSMUST00000144541.3 Gm11376 (from geneSymbol) ENSMUST00000144541.1 ENSMUST00000144541.2 uc288ltl.1 uc288ltl.2 uc288ltl.1 uc288ltl.2 
ENSMUST00000144575.3 Gm16085 ENSMUST00000144575.3 Gm16085 (from geneSymbol) ENSMUST00000144575.1 ENSMUST00000144575.2 uc288jal.1 uc288jal.2 uc288jal.3 uc288jal.1 uc288jal.2 uc288jal.3 
ENSMUST00000144578.2 Zfp128 ENSMUST00000144578.2 zinc finger protein 128 (from RefSeq NM_153802.4) ENSMUST00000144578.1 NM_153802 Q52KP6 Q8BGV5 Q8BJ50 ZNF8_MOUSE Zfp128 Znf8 uc009fek.1 uc009fek.2 uc009fek.3 uc009fek.4 Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins. Interacts with SMAD1 (via MH1 and MH2 domains). Interacts with SMAD5. Interacts weakly with SMAD2, SMAD3 and SMAD4. Nucleus Strongly expressed in testis, where it localizes to seminiferous tubules. Weakly expressed in heart, brain, lung, liver and kidney. Ubiquitously expressed in embryos. Detected from stage 7 dpc onwards, reaching peak levels at stage 11 dpc and declining by stages 15 dpc and 17 dpc. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC27668.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleic acid binding protein binding nucleus regulation of transcription, DNA-templated BMP signaling pathway metal ion binding uc009fek.1 uc009fek.2 uc009fek.3 uc009fek.4 
ENSMUST00000144585.9 Sbf1 ENSMUST00000144585.9 SET binding factor 1, transcript variant 1 (from RefSeq NM_001170561.1) B2RXQ1 B2RXX4 B7ZWK2 ENSMUST00000144585.1 ENSMUST00000144585.2 ENSMUST00000144585.3 ENSMUST00000144585.4 ENSMUST00000144585.5 ENSMUST00000144585.6 ENSMUST00000144585.7 ENSMUST00000144585.8 Kiaa3020 MTMR5_MOUSE Mtmr5 NM_001170561 Q4QQM2 Q6ZPE2 Q8BK68 Q8K2Z0 uc011zxu.1 uc011zxu.2 uc011zxu.3 Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location. May function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. Heterodimer with lipid phosphatase MTMR2. Interacts with KMT2A/MLL1 (via SET domain). Interacts with SUV39H1. Cytoplasm Cytoplasm, perinuclear region Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZPE2-1; Sequence=Displayed; Name=2; IsoId=Q6ZPE2-2; Sequence=VSP_047523; The C-terminal domain mediates interaction with MTMR2. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 1422 in the dsPTPase catalytic loop and does not have phosphatase activity (By similarity). The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Sequence=AAH29156.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC98295.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; regulation of cell growth pseudophosphatase activity guanyl-nucleotide exchange factor activity cytoplasm spermatogenesis nuclear body Rab guanyl-nucleotide exchange factor activity phosphatase regulator activity negative regulation of catalytic activity regulation of GTPase activity perinuclear region of cytoplasm uc011zxu.1 uc011zxu.2 uc011zxu.3 
ENSMUST00000144594.2 Gm16838 ENSMUST00000144594.2 Gm16838 (from geneSymbol) AK080565 ENSMUST00000144594.1 uc291fca.1 uc291fca.2 uc291fca.1 uc291fca.2 
ENSMUST00000144607.2 Gm14258 ENSMUST00000144607.2 Gm14258 (from geneSymbol) AK078707 ENSMUST00000144607.1 uc290cvs.1 uc290cvs.2 uc290cvs.1 uc290cvs.2 
ENSMUST00000144629.8 Adad1 ENSMUST00000144629.8 adenosine deaminase domain containing 1 (from RefSeq NM_009350.3) A2AAD7 A2AAD8 A2AAV1 ADAD1_MOUSE ENSMUST00000144629.1 ENSMUST00000144629.2 ENSMUST00000144629.3 ENSMUST00000144629.4 ENSMUST00000144629.5 ENSMUST00000144629.6 ENSMUST00000144629.7 NM_009350 Q08EL2 Q3V0N7 Q5SUE7 Q62309 Q9JLB6 Tenr uc008pah.1 uc008pah.2 uc008pah.3 Required for male fertility and normal male germ cell differentiation (PubMed:32665638). Plays a role in spermatogenesis (PubMed:15649457). Binds to RNA but not to DNA (PubMed:15649457). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5SUE7-1; Sequence=Displayed; Name=2; IsoId=Q5SUE7-2; Sequence=VSP_029227, VSP_029228; Name=3; IsoId=Q5SUE7-3; Sequence=VSP_029229; Testis-specific. Detected in round spermatid cells from stage II-XI (at protein level). Expressed in germ cells from mid- pachytene spermatocytes to mid-round spermatids. Mice exhibit spermatozoa retention in stage IX tubules and a reduction in the number of sperm in the epididymis, leading to a reduction in fertility (PubMed:15649457). Show defects in germ-cell development (PubMed:32665638). Belongs to the ADAD family. Sequence=CAM18414.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM28072.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM28078.1; Type=Erroneous gene model prediction; Evidence=; RNA binding double-stranded RNA binding double-stranded RNA adenosine deaminase activity adenosine deaminase activity nucleus nucleolus cytoplasm adenosine to inosine editing RNA processing multicellular organism development spermatogenesis spermatid development tRNA-specific adenosine deaminase activity cell differentiation uc008pah.1 uc008pah.2 uc008pah.3 
ENSMUST00000144637.2 Gm12682 ENSMUST00000144637.2 Gm12682 (from geneSymbol) ENSMUST00000144637.1 uc290oag.1 uc290oag.2 uc290oag.1 uc290oag.2 
ENSMUST00000144649.2 Gm14257 ENSMUST00000144649.2 Gm14257 (from geneSymbol) ENSMUST00000144649.1 KY467911 uc290bse.1 uc290bse.2 uc290bse.1 uc290bse.2 
ENSMUST00000144660.3 Gm28551 ENSMUST00000144660.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BFS9-1; Sequence=Displayed; Name=2; IsoId=Q8BFS9-2; Sequence=VSP_032353; (from UniProt Q8BFS9) AK034746 ASND1_MOUSE Asnsd1 ENSMUST00000144660.1 ENSMUST00000144660.2 Q3THX2 Q3U2Y8 Q3U317 Q8BFS9 Q8BM66 Q91YY3 uc287icp.1 uc287icp.2 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BFS9-1; Sequence=Displayed; Name=2; IsoId=Q8BFS9-2; Sequence=VSP_032353; Sequence=BAC28818.1; Type=Frameshift; Evidence=; Sequence=BAE33002.1; Type=Frameshift; Evidence=; asparagine synthase (glutamine-hydrolyzing) activity asparagine biosynthetic process glutamine metabolic process cellular amino acid biosynthetic process uc287icp.1 uc287icp.2 
ENSMUST00000144662.8 Fam111a ENSMUST00000144662.8 Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors. Required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis. (from UniProt Q9D2L9) AK172402 ENSMUST00000144662.1 ENSMUST00000144662.2 ENSMUST00000144662.3 ENSMUST00000144662.4 ENSMUST00000144662.5 ENSMUST00000144662.6 ENSMUST00000144662.7 F111A_MOUSE Fam111a Q3T9N2 Q8BLH2 Q8CI07 Q8VE75 Q9CU11 Q9D2L9 uc008guf.1 uc008guf.2 uc008guf.3 Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors. Required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis. Interacts (via PIP-box) with PCNA; this interaction is direct. Nucleus Chromosome Cytoplasm Note=Mainly localizes to nucleus: colocalizes with PCNA on replication sites. The PIP-box mediates the interaction with PCNA. Autocatalytically cleaved; autocatalytic cleavage takes place in trans. Belongs to the FAM111 family. Sequence=AAH38020.1; Type=Frameshift; Evidence=; chromatin fibrillar center molecular_function nucleus cytoplasm DNA replication negative regulation of viral genome replication uc008guf.1 uc008guf.2 uc008guf.3 
ENSMUST00000144668.8 Dhdds ENSMUST00000144668.8 dehydrodolichyl diphosphate synthase, transcript variant 5 (from RefSeq NM_001362962.1) A3KGL4 DHDDS_MOUSE Dhdds ENSMUST00000144668.1 ENSMUST00000144668.2 ENSMUST00000144668.3 ENSMUST00000144668.4 ENSMUST00000144668.5 ENSMUST00000144668.6 ENSMUST00000144668.7 NM_001362962 Q3UF13 Q8BZ16 Q8BZK8 Q99KU1 uc008vdu.1 uc008vdu.2 uc008vdu.3 With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Reaction=(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = di- trans,poly-cis-polyprenyl diphosphate + n diphosphate; Xref=Rhea:RHEA:53008, Rhea:RHEA-COMP:13431, ChEBI:CHEBI:33019, ChEBI:CHEBI:128769, ChEBI:CHEBI:136960, ChEBI:CHEBI:175763; EC=2.5.1.87; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 magnesium ion per subunit. ; Protein modification; protein glycosylation. Lipid metabolism. Forms an active dehydrodolichyl diphosphate synthase complex with NUS1. Interacts with NPC2. Endoplasmic reticulum membrane ; Peripheral membrane protein Note=colocalizes with calnexin. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99KU1-1; Sequence=Displayed; Name=2; IsoId=Q99KU1-2; Sequence=VSP_010032; The catalytic site at NUS1-DHDDS interface accomodates both the allylic and the homoallylic IPP substrates to the S1 and S2 pockets respectively. The beta-phosphate groups of IPP substrates form hydrogen bonds with the RXG motif of NUS1 and four conserved residues of DHDDS (Arg-85, Arg-205, Arg-211 and Ser-213), while the allylic isopentenyl group is pointed toward the hydrophobic tunnel of the S1 pocket where the product elongation occurs. Belongs to the UPP synthase family. polyprenyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation dolichyl diphosphate biosynthetic process lipid metabolic process membrane polyprenol biosynthetic process transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups dehydrodolichyl diphosphate synthase activity dehydrodolichyl diphosphate synthase complex uc008vdu.1 uc008vdu.2 uc008vdu.3 
ENSMUST00000144680.2 Gm16263 ENSMUST00000144680.2 Gm16263 (from geneSymbol) ENSMUST00000144680.1 uc288qel.1 uc288qel.2 uc288qel.1 uc288qel.2 
ENSMUST00000144689.3 Gm11682 ENSMUST00000144689.3 Gm11682 (from geneSymbol) ENSMUST00000144689.1 ENSMUST00000144689.2 uc288dfz.1 uc288dfz.2 uc288dfz.3 uc288dfz.1 uc288dfz.2 uc288dfz.3 
ENSMUST00000144719.9 Flicr ENSMUST00000144719.9 Foxp3 regulating long intergenic noncoding RNA (from RefSeq NR_029473.1) ENSMUST00000144719.1 ENSMUST00000144719.2 ENSMUST00000144719.3 ENSMUST00000144719.4 ENSMUST00000144719.5 ENSMUST00000144719.6 ENSMUST00000144719.7 ENSMUST00000144719.8 NR_029473 uc009slk.1 uc009slk.2 uc009slk.3 uc009slk.4 uc009slk.1 uc009slk.2 uc009slk.3 uc009slk.4 
ENSMUST00000144724.3 Or1e32 ENSMUST00000144724.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRX6) A7DTG5 ENSMUST00000144724.1 ENSMUST00000144724.2 Olfr392 Or1e32 Q7TRX6 Q7TRX6_MOUSE uc033fya.1 uc033fya.2 uc033fya.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033fya.1 uc033fya.2 uc033fya.3 
ENSMUST00000144738.2 Gm15726 ENSMUST00000144738.2 Gm15726 (from geneSymbol) ENSMUST00000144738.1 uc292rux.1 uc292rux.2 uc292rux.1 uc292rux.2 
ENSMUST00000144742.6 Cenpa ENSMUST00000144742.6 centromere protein A, transcript variant 6 (from RefSeq NR_126074.1) CENPA_MOUSE ENSMUST00000144742.1 ENSMUST00000144742.2 ENSMUST00000144742.3 ENSMUST00000144742.4 ENSMUST00000144742.5 NR_126074 O35216 Q545C9 uc008wvt.1 uc008wvt.2 uc008wvt.3 uc008wvt.4 Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]. Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well- ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:27499292). Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. CENPA modulates the DNA-binding characteristics of nucleosomes so that protruding DNA ends have higher flexibility than in nucleosomes containing conventional histone H3. Inhibits binding of histone H1 to nucleosomes, since histone H1 binds preferentially to rigid DNA linkers that protrude from nucleosomes. Nucleosomes containing CENPA also contain histone H2A variants such as MACROH2A and H2A.Z/H2AZ1. The CENPA-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers. Can assemble into nucleosomes that contain both CENPA and histone H3.3; these nucleosomes interact with a single CENPC chain. Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts (via CATD domain) with HJURP; the interaction is direct and is required for its localization to centromeres. Interacts with CENPC, CENPN and CENPT; interaction is direct. Part of a centromere complex consisting of CENPA, CENPT and CENPW. Identified in centromere complexes containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1. Can self-associate. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro). Interacts with CDK1, PPP1CA and RBBP7. Nucleus Chromosome, centromere Note=Localizes exclusively to sites of kinetochore assembly in centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height. Phosphorylation at Ser-62 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location. The CATD (CENPA targeting domain) region is responsible for the more compact structure of nucleosomes containing CENPA. It is necessary and sufficient to mediate the localization into centromeres. Poly-ADP-ribosylated by PARP1. Trimethylated by NTMT1 at the N-terminal glycine after cleavage of Met-1. Methylation is low before incorporation into nucleosomes and increases with cell cycle progression, with the highest levels in mitotic nucleosomes. Phosphorylated by CDK1 at Ser-62 during early mitosis; this abolishes association with chromatin and centromeres, prevents interaction with HJURP and thereby prevents premature assembly of CENPA into centromeres. Dephosphorylated at Ser-62 by PPP1CA during late mitosis. Belongs to the histone H3 family. establishment of mitotic spindle orientation mitotic cytokinesis chromosome, centromeric region kinetochore condensed chromosome kinetochore condensed nuclear chromosome kinetochore condensed nuclear chromosome, centromeric region nucleosome nuclear nucleosome condensed chromosome inner kinetochore DNA binding nucleus nucleoplasm chromosome nuclear pericentric heterochromatin protein heterodimerization activity kinetochore assembly protein localization to chromosome, centromeric region uc008wvt.1 uc008wvt.2 uc008wvt.3 uc008wvt.4 
ENSMUST00000144757.2 Gm15704 ENSMUST00000144757.2 Gm15704 (from geneSymbol) AK029019 ENSMUST00000144757.1 uc291kfd.1 uc291kfd.2 uc291kfd.1 uc291kfd.2 
ENSMUST00000144760.3 Gm28845 ENSMUST00000144760.3 Gm28845 (from geneSymbol) A0A9L6KE19 A0A9L6KE19_MOUSE AK164708 ENSMUST00000144760.1 ENSMUST00000144760.2 Gm28845 uc287iuz.1 uc287iuz.2 uc287iuz.1 uc287iuz.2 
ENSMUST00000144765.2 Gm12395 ENSMUST00000144765.2 Gm12395 (from geneSymbol) ENSMUST00000144765.1 uc290mba.1 uc290mba.2 uc290mba.1 uc290mba.2 
ENSMUST00000144818.2 Gm14168 ENSMUST00000144818.2 Gm14168 (from geneSymbol) AK050354 ENSMUST00000144818.1 uc290byh.1 uc290byh.2 uc290byh.1 uc290byh.2 
ENSMUST00000144826.2 Noct ENSMUST00000144826.2 Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Represses translation and promotes degradation of target mRNA molecules (By similarity). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (PubMed:20685873, PubMed:20498072). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (PubMed:20498072, PubMed:22082366, PubMed:21820310, PubMed:22073225, PubMed:22331129). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (PubMed:20498072, PubMed:22082366). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (PubMed:20498072). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (PubMed:22073225, PubMed:20685873). Critical for proper development of early embryos (PubMed:23449310). (from UniProt O35710) Ccr4 Ccrn4l ENSMUST00000144826.1 NOCT_MOUSE Noc Noct O35710 Q9QZG9 U70139 uc008pdn.1 uc008pdn.2 uc008pdn.3 uc008pdn.4 Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Represses translation and promotes degradation of target mRNA molecules (By similarity). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (PubMed:20685873, PubMed:20498072). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (PubMed:20498072, PubMed:22082366, PubMed:21820310, PubMed:22073225, PubMed:22331129). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (PubMed:20498072, PubMed:22082366). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (PubMed:20498072). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (PubMed:22073225, PubMed:20685873). Critical for proper development of early embryos (PubMed:23449310). Reaction=H2O + NADP(+) = NAD(+) + phosphate; Xref=Rhea:RHEA:28050, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57540, ChEBI:CHEBI:58349; EC=3.1.3.108; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28051; Evidence=; Reaction=H2O + NADPH = NADH + phosphate; Xref=Rhea:RHEA:60664, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:57945; EC=3.1.3.108; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60665; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions, but the ions are only loosely bound to the protein. ; Interacts with PPARG. Cytoplasm Nucleus Cytoplasm, perinuclear region Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O35710-1; Sequence=Displayed; Name=2; IsoId=O35710-2; Sequence=VSP_016677; Highly expressed in the differentiated adipocyte (at protein level). Ubiquitous. Expression is highest in oocytes, begins to decrease after fertilization by the 4-cell stage and then slightly increases up to the blastocyst stage. Immediate early gene (IEG) showing acute responses to several stimuli including serum shock, phorbol ester, lipopolysaccharide (LPS) and rosiglitazone, a PPARG agonist. Exhibits a high amplitude circadian rhythm with maximal levels in early evening. In constant darkness or constant light, the amplitude of the rhythm decreases. Expression is regulated by both light and food-entrained cues and by the CLOCK-BMAL1 heterodimer and PPARG. Up-regulated in cells undergoing adipogenesis. Mice exhibit metabolic defects including a resistance to diet-induced obesity, decreased fat storage, changes in lipid-related gene expression profiles in the liver, and altered glucose and insulin sensitivities. Exhibit a delayed early embryo development and at 12 weeks of age show enhanced skeletal mass and increased osteoblastogenesis. Belongs to the CCR4/nocturin family. Was initially shown to have low deadenylase activity that was lost when the metal-binding Glu was mutated (PubMed:17400819). Later studies showed that the purified protein lacked deadenylase activity (PubMed:29860338). Was subsequently shown to act as a phosphatase (By similarity). Sequence=AAB62717.1; Type=Frameshift; Evidence=; 3'-5'-exoribonuclease activity deadenylation-dependent decapping of nuclear-transcribed mRNA P-body RNA binding mRNA binding nuclease activity exonuclease activity poly(A)-specific ribonuclease activity protein binding nucleus cytoplasm mitochondrion mRNA processing NADP metabolic process circadian rhythm response to extracellular stimulus negative regulation of gene expression dephosphorylation hydrolase activity NADP phosphatase activity response to lipopolysaccharide circadian regulation of gene expression cytoplasmic mRNA processing body assembly regulation of circadian rhythm positive regulation of fat cell differentiation negative regulation of osteoblast differentiation regulation of embryonic development metal ion binding mRNA stabilization perinuclear region of cytoplasm rhythmic process nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic uc008pdn.1 uc008pdn.2 uc008pdn.3 uc008pdn.4 
ENSMUST00000144832.4 ENSMUSG00000121512 ENSMUST00000144832.4 olfactory receptor family 1 subfamily E member 36, pseudogene 1, transcript variant 1 (from RefSeq NR_033528.1) ENSMUST00000144832.1 ENSMUST00000144832.2 ENSMUST00000144832.3 NR_033528 uc007kas.1 uc007kas.2 uc007kas.3 uc007kas.4 uc007kas.5 uc007kas.6 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. uc007kas.1 uc007kas.2 uc007kas.3 uc007kas.4 uc007kas.5 uc007kas.6 
ENSMUST00000144843.8 Slain2 ENSMUST00000144843.8 SLAIN motif family, member 2, transcript variant 2 (from RefSeq NM_001113423.2) ENSMUST00000144843.1 ENSMUST00000144843.2 ENSMUST00000144843.3 ENSMUST00000144843.4 ENSMUST00000144843.5 ENSMUST00000144843.6 ENSMUST00000144843.7 Kiaa1458 NM_001113423 Q05DK1 Q3UJI9 Q6ZPQ5 Q8CI08 SLAI2_MOUSE uc008xsh.1 uc008xsh.2 uc008xsh.3 uc008xsh.4 uc008xsh.5 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. Interacts with CLIP1, CLIP2, CKAP5, CLASP1, MAPRE1 and MAPRE3. Cytoplasm, cytoskeleton Note=Colocalizes with microtubules. Detected at the plus end of growing microtubules (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CI08-1; Sequence=Displayed; Name=2; IsoId=Q8CI08-2; Sequence=VSP_030834; The N-terminus forms a two-stranded coiled coil. Is highly phosphorylated during mitosis, but not during interphase. The highly phosphorylated form does not localize at microtubule plus ends and does not interact with MAPRE1 or CKAP5 (By similarity). Belongs to the SLAIN motif-containing family. Sequence=AAH10836.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH10836.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential vector sequence.; Evidence=; Sequence=AAH38019.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC98175.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE27166.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cytoplasm centrosome cytosol cytoskeleton microtubule nucleation microtubule cytoskeleton regulation of microtubule polymerization positive regulation of microtubule polymerization cytoplasmic microtubule organization microtubule plus-end uc008xsh.1 uc008xsh.2 uc008xsh.3 uc008xsh.4 uc008xsh.5 
ENSMUST00000144854.2 Gm16141 ENSMUST00000144854.2 RIKEN cDNA 4933406G16 gene (from RefSeq NR_046037.1) ENSMUST00000144854.1 NR_046037 uc029rkt.1 uc029rkt.2 uc029rkt.3 uc029rkt.1 uc029rkt.2 uc029rkt.3 
ENSMUST00000144870.2 Gm13219 ENSMUST00000144870.2 Gm13219 (from geneSymbol) AK035738 ENSMUST00000144870.1 uc008ihb.1 uc008ihb.2 uc008ihb.1 uc008ihb.2 
ENSMUST00000144875.2 Gm11412 ENSMUST00000144875.2 Gm11412 (from geneSymbol) AK085025 ENSMUST00000144875.1 uc290nlf.1 uc290nlf.2 uc290nlf.1 uc290nlf.2 
ENSMUST00000144876.2 Gm12200 ENSMUST00000144876.2 Gm12200 (from geneSymbol) AK076967 ENSMUST00000144876.1 uc287xxb.1 uc287xxb.2 uc287xxb.1 uc287xxb.2 
ENSMUST00000144885.3 Or4a71 ENSMUST00000144885.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGM7) ENSMUST00000144885.1 ENSMUST00000144885.2 Olfr1243 Or4a71 Q8VGM7 Q8VGM7_MOUSE uc289ycs.1 uc289ycs.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ycs.1 uc289ycs.2 
ENSMUST00000144896.2 Dnmt3aos ENSMUST00000144896.2 DNA methyltransferase 3A, opposite strand (from RefSeq NR_045884.1) ENSMUST00000144896.1 NR_045884 uc029rqn.1 uc029rqn.2 uc029rqn.1 uc029rqn.2 
ENSMUST00000144897.2 Slx1b ENSMUST00000144897.2 SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae), transcript variant 1 (from RefSeq NM_029420.4) ENSMUST00000144897.1 Giyd1 Giyd2 NM_029420 Q8BX32 Q9D609 SLX1_MOUSE Slx1 uc009jsh.1 uc009jsh.2 uc009jsh.3 uc009jsh.4 Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Forms a heterodimer with SLX4. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BX32-1; Sequence=Displayed; Name=2; IsoId=Q8BX32-2; Sequence=VSP_033332, VSP_033333; Expressed in testis, colon, bone marrow, brain, thymus and to a lesser extent in heart, kidney, skeletal muscle and spleen. Belongs to the SLX1 family. double-strand break repair via homologous recombination nuclease activity endonuclease activity nucleus nucleoplasm DNA repair DNA recombination cellular response to DNA damage stimulus crossover junction endodeoxyribonuclease activity hydrolase activity 5'-flap endonuclease activity Slx1-Slx4 complex metal ion binding nucleic acid phosphodiester bond hydrolysis t-circle formation positive regulation of t-circle formation uc009jsh.1 uc009jsh.2 uc009jsh.3 uc009jsh.4 
ENSMUST00000144908.3 Or4c108 ENSMUST00000144908.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2ATG2) A2ATG2 A2ATG2_MOUSE ENSMUST00000144908.1 ENSMUST00000144908.2 Olfr1213 Or4c108 uc033hoa.1 uc033hoa.2 uc033hoa.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033hoa.1 uc033hoa.2 uc033hoa.3 
ENSMUST00000144914.3 Cdhr18 ENSMUST00000144914.3 cadherin related family member 18 (from RefSeq NM_001393529.1) Cdhr18 D3Z1Y0 D3Z1Y0_MOUSE ENSMUST00000144914.1 ENSMUST00000144914.2 Gm281 NM_001393529 uc288qvn.1 uc288qvn.2 molecular_function calcium ion binding cellular_component homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane cell-cell adhesion uc288qvn.1 uc288qvn.2 
ENSMUST00000144915.2 Gm16033 ENSMUST00000144915.2 Gm16033 (from geneSymbol) ENSMUST00000144915.1 uc287xpn.1 uc287xpn.2 uc287xpn.1 uc287xpn.2 
ENSMUST00000144922.2 Gm12296 ENSMUST00000144922.2 predicted gene 12296 (from RefSeq NR_153847.1) ENSMUST00000144922.1 NR_153847 uc007jll.1 uc007jll.2 uc007jll.3 uc007jll.1 uc007jll.2 uc007jll.3 
ENSMUST00000144950.8 Dnajb4 ENSMUST00000144950.8 DnaJ heat shock protein family (Hsp40) member B4, transcript variant 1 (from RefSeq NM_027287.5) DNJB4_MOUSE ENSMUST00000144950.1 ENSMUST00000144950.2 ENSMUST00000144950.3 ENSMUST00000144950.4 ENSMUST00000144950.5 ENSMUST00000144950.6 ENSMUST00000144950.7 NM_027287 Q3TS92 Q9D832 Q9D9U2 uc008rsr.1 uc008rsr.2 uc008rsr.3 uc008rsr.4 uc008rsr.5 Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Homodimer. The C-terminal section interacts with the C- terminal tail of OPRM1. Interacts also with SDIM1 (By similarity). Cytoplasm Cell membrane Cytoplasm, myofibril, sarcomere, Z line Knockout animals show muscle weakness and fiber atrophy with prominent diaphragm involvement and kyphosis. Knockout muscle and myotubes have myofibrillar disorganization and accumulated Z-disk proteins and protein chaperones. ATPase activator activity nucleoplasm cytoplasm cytosol plasma membrane protein folding membrane positive regulation of ATPase activity unfolded protein binding chaperone mediated protein folding requiring cofactor chaperone binding uc008rsr.1 uc008rsr.2 uc008rsr.3 uc008rsr.4 uc008rsr.5 
ENSMUST00000144975.2 Gm11684 ENSMUST00000144975.2 Gm11684 (from geneSymbol) ENSMUST00000144975.1 uc288dfh.1 uc288dfh.2 uc288dfh.1 uc288dfh.2 
ENSMUST00000144984.3 Gm15340 ENSMUST00000144984.3 Gm15340 (from geneSymbol) AK040426 ENSMUST00000144984.1 ENSMUST00000144984.2 uc008acg.1 uc008acg.2 uc008acg.3 uc008acg.4 uc008acg.1 uc008acg.2 uc008acg.3 uc008acg.4 
ENSMUST00000144990.3 Gm12195 ENSMUST00000144990.3 Gm12195 (from geneSymbol) ENSMUST00000144990.1 ENSMUST00000144990.2 uc287xvf.1 uc287xvf.2 uc287xvf.3 uc287xvf.1 uc287xvf.2 uc287xvf.3 
ENSMUST00000145021.2 Myhas ENSMUST00000145021.2 Myhas (from geneSymbol) AK009488 ENSMUST00000145021.1 uc287zaz.1 uc287zaz.2 uc287zaz.1 uc287zaz.2 
ENSMUST00000145041.4 Ces1h ENSMUST00000145041.4 carboxylesterase 1H (from RefSeq NM_001370830.1) Ces1h D3Z298 D3Z298_MOUSE ENSMUST00000145041.1 ENSMUST00000145041.2 ENSMUST00000145041.3 NM_001370830 uc292cch.1 uc292cch.2 Belongs to the type-B carboxylesterase/lipase family. sterol esterase activity triglyceride lipase activity extracellular space lipid catabolic process hydrolase activity carboxylic ester hydrolase activity uc292cch.1 uc292cch.2 
ENSMUST00000145042.2 5930430L01Rik ENSMUST00000145042.2 RIKEN cDNA 5930430L01 gene, transcript variant 2 (from RefSeq NR_102384.1) ENSMUST00000145042.1 NR_102384 uc033inx.1 uc033inx.2 uc033inx.3 uc033inx.4 uc033inx.5 uc033inx.1 uc033inx.2 uc033inx.3 uc033inx.4 uc033inx.5 
ENSMUST00000145068.3 1700047K16Rik ENSMUST00000145068.3 1700047K16Rik (from geneSymbol) AK006714 ENSMUST00000145068.1 ENSMUST00000145068.2 uc287yjh.1 uc287yjh.2 uc287yjh.3 uc287yjh.1 uc287yjh.2 uc287yjh.3 
ENSMUST00000145081.9 B430212C06Rik ENSMUST00000145081.9 RIKEN cDNA B430212C06 gene (from RefSeq NR_033214.1) ENSMUST00000145081.1 ENSMUST00000145081.2 ENSMUST00000145081.3 ENSMUST00000145081.4 ENSMUST00000145081.5 ENSMUST00000145081.6 ENSMUST00000145081.7 ENSMUST00000145081.8 NR_033214 uc008fmb.1 uc008fmb.2 uc008fmb.3 uc008fmb.1 uc008fmb.2 uc008fmb.3 
ENSMUST00000145085.3 Gm16741 ENSMUST00000145085.3 Gm16741 (from geneSymbol) BC050878 ENSMUST00000145085.1 ENSMUST00000145085.2 uc288qqu.1 uc288qqu.2 uc288qqu.1 uc288qqu.2 
ENSMUST00000145095.2 Gm12290 ENSMUST00000145095.2 predicted gene 12290 (from RefSeq NR_166814.1) ENSMUST00000145095.1 NR_166814 uc287yyx.1 uc287yyx.2 uc287yyx.1 uc287yyx.2 
ENSMUST00000145105.5 Gm14261 ENSMUST00000145105.5 predicted gene 14261 (from RefSeq NR_166178.1) ENSMUST00000145105.1 ENSMUST00000145105.2 ENSMUST00000145105.3 ENSMUST00000145105.4 NR_166178 uc008obi.1 uc008obi.2 uc008obi.3 uc008obi.4 uc008obi.5 uc008obi.1 uc008obi.2 uc008obi.3 uc008obi.4 uc008obi.5 
ENSMUST00000145111.8 9130019P16Rik ENSMUST00000145111.8 RIKEN cDNA 9130019P16 gene (from RefSeq NR_033635.1) ENSMUST00000145111.1 ENSMUST00000145111.2 ENSMUST00000145111.3 ENSMUST00000145111.4 ENSMUST00000145111.5 ENSMUST00000145111.6 ENSMUST00000145111.7 NR_033635 uc012eme.1 uc012eme.2 uc012eme.1 uc012eme.2 
ENSMUST00000145127.3 Gm12069 ENSMUST00000145127.3 predicted gene 12069 (from RefSeq NR_166816.1) ENSMUST00000145127.1 ENSMUST00000145127.2 NR_166816 uc287xbd.1 uc287xbd.2 uc287xbd.3 uc287xbd.1 uc287xbd.2 uc287xbd.3 
ENSMUST00000145163.2 Gm13645 ENSMUST00000145163.2 Gm13645 (from geneSymbol) AK155847 ENSMUST00000145163.1 uc290sfc.1 uc290sfc.2 uc290sfc.1 uc290sfc.2 
ENSMUST00000145165.8 Gm49320 ENSMUST00000145165.8 Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). (from UniProt Q8CE90) AK028772 ENSMUST00000145165.1 ENSMUST00000145165.2 ENSMUST00000145165.3 ENSMUST00000145165.4 ENSMUST00000145165.5 ENSMUST00000145165.6 ENSMUST00000145165.7 MP2K7_MOUSE Map2k7 Mkk7 O35406 O35720 O35871 O35872 O54780 O70242 O70243 Q8BSP1 Q8CE90 Q9QWG6 Q9R1Z3 Q9R1Z4 Q9R1Z5 Q9R1Z6 uc291xwq.1 uc291xwq.2 Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence= Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK. Isoforms 3 and 4 have lower basal activity but a higher level of inducible activation, than isoforms 2, 6, 7 and 8. Interacts with RASSF7, the interaction promotes phosphorylation. Interacts with VRK2 (By similarity). Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1 (By similarity). Interacts with SH3RF1, MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Found in a complex with SH3RF1, RAC1, MAP3K11/MLK3, MAPK8IP1/JIP1 and MAPK8/JNK1 (PubMed:23963642). Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1, MAPK8IP1/JIP1, MAPK8/JNK1 and MAPK9/JNK2 (PubMed:27084103). Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=8; Name=1 ; IsoId=Q8CE90-1; Sequence=Displayed; Name=2 ynonyms=a , beta 1 ; IsoId=Q8CE90-2; Sequence=VSP_052266, VSP_052268, VSP_052269; Name=3 ; Synonyms=alpha 2 ; IsoId=Q8CE90-3; Sequence=VSP_052265, VSP_052270, VSP_052271; Name=4 ; Synonyms=alpha 1 ; IsoId=Q8CE90-4; Sequence=VSP_052265, VSP_052268, VSP_052269; Name=5 ; Synonyms=b ; IsoId=Q8CE90-5; Sequence=VSP_052264, VSP_052267, VSP_052268, VSP_052269; Name=6 ynonyms=b , gamma 1 ; IsoId=Q8CE90-6; Sequence=VSP_052268, VSP_052269; Name=7 ; Synonyms=gamma 2 ; IsoId=Q8CE90-7; Sequence=VSP_052270, VSP_052271; Name=8 ; Synonyms=beta 2 ; IsoId=Q8CE90-8; Sequence=VSP_052266, VSP_052270, VSP_052271; Expressed at high levels in brain, lung, liver, skeletal muscle, kidney, and testis and at lower levels in the heart and spleen. Expressed at high levels in the brain, spinal cord, eyes, muscle, lungs, vertebrae, and intestine and at lower levels in the heart and livers at 12.5 dpc. At later stages of embryogenesis (14.5 dpc, 16.5 dpc, and 18.5 dpc) high levels were found in the brain, retina, bone marrow, skin, intestine, lung epithelium and the epithelial layers lining the olfactory cavity and developing teeth and whiskers. The DVD domain (residues 393-413) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation. The D domain (residues 37-73) contains a conserved docking site and is required for the binding to MAPK substrates. Activated by phosphorylation on Ser-287 and Thr-291 by MAP kinase kinase kinases (MAP3Ks). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. nucleotide binding activation of MAPK activity magnesium ion binding positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein tyrosine kinase activity protein binding ATP binding nucleus cytoplasm cytosol protein phosphorylation apoptotic process response to osmotic stress JNK cascade activation of JUN kinase activity protein C-terminus binding JUN kinase kinase activity response to heat response to UV response to wounding kinase activity phosphorylation transferase activity SAP kinase activity peptidyl-tyrosine phosphorylation enzyme binding protein kinase binding protein phosphatase binding signal transduction by protein phosphorylation mitogen-activated protein kinase kinase kinase binding activation of protein kinase activity positive regulation of telomere maintenance via telomerase response to tumor necrosis factor positive regulation of neuron apoptotic process positive regulation of transcription, DNA-templated positive regulation of JNK cascade metal ion binding stress-activated MAPK cascade positive regulation of telomerase activity positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to interleukin-1 positive regulation of telomere capping regulation of motor neuron apoptotic process uc291xwq.1 uc291xwq.2 
ENSMUST00000145167.9 Selenoi ENSMUST00000145167.9 selenoprotein I, transcript variant 1 (from RefSeq NM_027652.3) D5Wsu178e ENSMUST00000145167.1 ENSMUST00000145167.2 ENSMUST00000145167.3 ENSMUST00000145167.4 ENSMUST00000145167.5 ENSMUST00000145167.6 ENSMUST00000145167.7 ENSMUST00000145167.8 EPT1_MOUSE Ept1 Kiaa1724 NM_027652 Q3KQQ5 Q80TA1 Q8BG08 Selenoi uc008wvh.1 uc008wvh.2 uc008wvh.3 The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]. Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine/PE from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway. PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes. The enzyme is critical for the synthesis of several PE species and could also catalyze the synthesis of ether-linked phospholipids like plasmanyl- and plasmenyl-PE which could explain it is required for proper myelination and neurodevelopment. Reaction=a 1,2-diacyl-sn-glycerol + CDP-ethanolamine = a 1,2-diacyl-sn- glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:32943, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:64612; EC=2.7.8.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32944; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the CDP-alcohol phosphatidyltransferase class-I family. Sequence=BAC33214.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC37608.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC65826.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; ethanolaminephosphotransferase activity endoplasmic reticulum membrane Golgi apparatus lipid metabolic process phosphatidylethanolamine biosynthetic process phospholipid biosynthetic process membrane integral component of membrane transferase activity phosphotransferase activity, for other substituted phosphate groups metal ion binding uc008wvh.1 uc008wvh.2 uc008wvh.3 
ENSMUST00000145170.2 Gm13708 ENSMUST00000145170.2 Gm13708 (from geneSymbol) ENSMUST00000145170.1 uc289wyj.1 uc289wyj.2 uc289wyj.1 uc289wyj.2 
ENSMUST00000145178.2 Gm14011 ENSMUST00000145178.2 Gm14011 (from geneSymbol) ENSMUST00000145178.1 uc290ain.1 uc290ain.2 uc290ain.1 uc290ain.2 
ENSMUST00000145182.2 Gm12023 ENSMUST00000145182.2 Gm12023 (from geneSymbol) ENSMUST00000145182.1 uc287wtu.1 uc287wtu.2 uc287wtu.1 uc287wtu.2 
ENSMUST00000145204.2 Gm14242 ENSMUST00000145204.2 Gm14242 (from geneSymbol) ENSMUST00000145204.1 uc290cgl.1 uc290cgl.2 uc290cgl.1 uc290cgl.2 
ENSMUST00000145237.8 Zscan4f ENSMUST00000145237.8 zinc finger and SCAN domain containing 4F (from RefSeq NM_001110316.2) ENSMUST00000145237.1 ENSMUST00000145237.2 ENSMUST00000145237.3 ENSMUST00000145237.4 ENSMUST00000145237.5 ENSMUST00000145237.6 ENSMUST00000145237.7 NM_001110316 Q3URS2 ZSC4F_MOUSE uc009fdn.1 uc009fdn.2 Transcription factor required to regulate early development. Binds telomeres and plays a key role in genomic stability by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation (By similarity). Nucleus Chromosome, telomere Up-regulated in blastocyst outgrowths and is detectable in a mosaic fashion in ES cultures. chromosome, telomeric region nuclear chromosome, telomeric region nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus chromosome regulation of transcription, DNA-templated telomere maintenance via telomere lengthening metal ion binding uc009fdn.1 uc009fdn.2 
ENSMUST00000145263.2 Gm13066 ENSMUST00000145263.2 predicted gene 13066 (from RefSeq NR_189025.1) ENSMUST00000145263.1 NR_189025 uc290ryq.1 uc290ryq.2 uc290ryq.1 uc290ryq.2 
ENSMUST00000145269.3 1700095A21Rik ENSMUST00000145269.3 RIKEN cDNA 1700095A21 gene (from RefSeq NR_045468.1) ENSMUST00000145269.1 ENSMUST00000145269.2 NR_045468 uc008vsg.1 uc008vsg.2 uc008vsg.3 uc008vsg.4 uc008vsg.1 uc008vsg.2 uc008vsg.3 uc008vsg.4 
ENSMUST00000145279.9 Spag17os ENSMUST00000145279.9 Spag17os (from geneSymbol) AK035904 ENSMUST00000145279.1 ENSMUST00000145279.2 ENSMUST00000145279.3 ENSMUST00000145279.4 ENSMUST00000145279.5 ENSMUST00000145279.6 ENSMUST00000145279.7 ENSMUST00000145279.8 uc290iag.1 uc290iag.2 uc290iag.1 uc290iag.2 
ENSMUST00000145297.2 Gm14376 ENSMUST00000145297.2 Gm14376 (from geneSymbol) ENSMUST00000145297.1 KY468173 uc291xps.1 uc291xps.2 uc291xps.1 uc291xps.2 
ENSMUST00000145302.3 Dgkk ENSMUST00000145302.3 diacylglycerol kinase kappa (from RefSeq NM_177914.3) Dgkk ENSMUST00000145302.1 ENSMUST00000145302.2 F6UUZ3 F6UUZ3_MOUSE NM_177914 uc292mwh.1 uc292mwh.2 Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z- octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328; Evidence=; Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3- phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10273; Evidence=; Lipid metabolism; glycerolipid metabolism. Belongs to the eukaryotic diacylglycerol kinase family. nucleotide binding NAD+ kinase activity diacylglycerol kinase activity ATP binding plasma membrane response to oxidative stress signal transduction protein kinase C-activating G-protein coupled receptor signaling pathway kinase activity phosphorylation transferase activity intracellular signal transduction diacylglycerol metabolic process glycerolipid metabolic process lipid phosphorylation uc292mwh.1 uc292mwh.2 
ENSMUST00000145346.2 9430073C21Rik ENSMUST00000145346.2 9430073C21Rik (from geneSymbol) AK035006 ENSMUST00000145346.1 uc007jmf.1 uc007jmf.2 uc007jmf.3 uc007jmf.1 uc007jmf.2 uc007jmf.3 
ENSMUST00000145353.8 Cnot6 ENSMUST00000145353.8 CCR4-NOT transcription complex, subunit 6, transcript variant 1 (from RefSeq NM_001290741.2) CNOT6_MOUSE Ccr4 ENSMUST00000145353.1 ENSMUST00000145353.2 ENSMUST00000145353.3 ENSMUST00000145353.4 ENSMUST00000145353.5 ENSMUST00000145353.6 ENSMUST00000145353.7 Kiaa1194 NM_001290741 Q5NCL3 Q80V15 Q8K3P5 uc287xum.1 uc287xum.2 Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors. Mediates cell proliferation and cell survival and prevents cellular senescence. Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions, but the ions interact each with only 1 or 2 residues. ; Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. Interacts with CNOT7 and CNOT8 (By similarity). Interacts with UNR (PubMed:15314026). Interacts with ZFP36L1 (via N-terminus). Interacts with ZNF335 (By similarity). Cytoplasm Nucleus Note=Predominantly cytoplasmic. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K3P5-1; Sequence=Displayed; Name=2; IsoId=Q8K3P5-2; Sequence=VSP_009939; Name=3; IsoId=Q8K3P5-3; Sequence=VSP_009938; Expressed in embryonic stem (ES) cells. Belongs to the CCR4/nocturin family. Sequence=BAC98117.1; Type=Erroneous initiation; Evidence=; 3'-5'-exoribonuclease activity nuclear-transcribed mRNA poly(A) tail shortening RNA binding nuclease activity exonuclease activity exoribonuclease activity poly(A)-specific ribonuclease activity nucleus cytoplasm regulation of translation positive regulation of cell proliferation positive regulation of cytoplasmic mRNA processing body assembly hydrolase activity CCR4-NOT complex gene silencing by RNA exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay metal ion binding nuclear-transcribed mRNA catabolic process, no-go decay nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic positive regulation of ligand-dependent nuclear receptor transcription coactivator activity uc287xum.1 uc287xum.2 
ENSMUST00000145372.2 Gm15347 ENSMUST00000145372.2 Gm15347 (from geneSymbol) ENSMUST00000145372.1 uc291ygr.1 uc291ygr.2 uc291ygr.1 uc291ygr.2 
ENSMUST00000145383.2 Gm14505 ENSMUST00000145383.2 Gm14505 (from geneSymbol) ENSMUST00000145383.1 uc292nhz.1 uc292nhz.2 uc292nhz.1 uc292nhz.2 
ENSMUST00000145389.3 Gm13425 ENSMUST00000145389.3 Gm13425 (from geneSymbol) ENSMUST00000145389.1 ENSMUST00000145389.2 uc289uxr.1 uc289uxr.2 uc289uxr.1 uc289uxr.2 
ENSMUST00000145395.2 Gm12861 ENSMUST00000145395.2 Gm12861 (from geneSymbol) ENSMUST00000145395.1 uc290pje.1 uc290pje.2 uc290pje.1 uc290pje.2 
ENSMUST00000145401.8 Il9r ENSMUST00000145401.8 interleukin 9 receptor, transcript variant 2 (from RefSeq NM_008374.2) ENSMUST00000145401.1 ENSMUST00000145401.2 ENSMUST00000145401.3 ENSMUST00000145401.4 ENSMUST00000145401.5 ENSMUST00000145401.6 ENSMUST00000145401.7 Il9r NM_008374 Q78PA5 Q78PA5_MOUSE interleukin 9 receptor uc007iix.1 uc007iix.2 uc007iix.3 uc007iix.4 cytokine receptor activity membrane integral component of membrane cytokine-mediated signaling pathway uc007iix.1 uc007iix.2 uc007iix.3 uc007iix.4 
ENSMUST00000145410.2 Gm16010 ENSMUST00000145410.2 Gm16010 (from geneSymbol) AK142507 ENSMUST00000145410.1 uc009rcz.1 uc009rcz.2 uc009rcz.3 uc009rcz.1 uc009rcz.2 uc009rcz.3 
ENSMUST00000145411.2 Gm12703 ENSMUST00000145411.2 Gm12703 (from geneSymbol) AK086407 ENSMUST00000145411.1 uc290nvf.1 uc290nvf.2 uc290nvf.1 uc290nvf.2 
ENSMUST00000145415.2 Gm15829 ENSMUST00000145415.2 Gm15829 (from geneSymbol) AK007077 ENSMUST00000145415.1 uc289ehe.1 uc289ehe.2 uc289ehe.1 uc289ehe.2 
ENSMUST00000145417.2 ENSMUSG00000121727 ENSMUST00000145417.2 ENSMUSG00000121727 (from geneSymbol) ENSMUST00000145417.1 LF201417 uc289pcu.1 uc289pcu.2 uc289pcu.1 uc289pcu.2 
ENSMUST00000145464.2 Gm16246 ENSMUST00000145464.2 Gm16246 (from geneSymbol) AK137287 ENSMUST00000145464.1 uc057kof.1 uc057kof.2 uc057kof.1 uc057kof.2 
ENSMUST00000145489.2 Gm11632 ENSMUST00000145489.2 Gm11632 (from geneSymbol) ENSMUST00000145489.1 uc288bxb.1 uc288bxb.2 uc288bxb.1 uc288bxb.2 
ENSMUST00000145504.3 Banf2os ENSMUST00000145504.3 Banf2os (from geneSymbol) AK085768 ENSMUST00000145504.1 ENSMUST00000145504.2 uc057leg.1 uc057leg.2 uc057leg.3 uc057leg.4 uc057leg.1 uc057leg.2 uc057leg.3 uc057leg.4 
ENSMUST00000145510.2 Gm12802 ENSMUST00000145510.2 predicted gene 12802, transcript variant 2 (from RefSeq NR_188190.1) ENSMUST00000145510.1 NR_188190 uc008tzg.1 uc008tzg.2 uc008tzg.1 uc008tzg.2 
ENSMUST00000145517.3 Gm11535 ENSMUST00000145517.3 Gm11535 (from geneSymbol) ENSMUST00000145517.1 ENSMUST00000145517.2 uc288bqo.1 uc288bqo.2 uc288bqo.3 uc288bqo.1 uc288bqo.2 uc288bqo.3 
ENSMUST00000145525.3 E130215H24Rik ENSMUST00000145525.3 RIKEN cDNA E130215H24 gene (from RefSeq NR_040331.1) ENSMUST00000145525.1 ENSMUST00000145525.2 NR_040331 uc008mug.1 uc008mug.2 uc008mug.3 uc008mug.4 uc008mug.5 uc008mug.1 uc008mug.2 uc008mug.3 uc008mug.4 uc008mug.5 
ENSMUST00000145537.3 Spin2-ps8 ENSMUST00000145537.3 Spin2-ps8 (from geneSymbol) ENSMUST00000145537.1 ENSMUST00000145537.2 uc292nqr.1 uc292nqr.2 uc292nqr.3 uc292nqr.1 uc292nqr.2 uc292nqr.3 
ENSMUST00000145562.8 4930513N10Rik ENSMUST00000145562.8 RIKEN cDNA 4930513N10 gene (from RefSeq NR_015574.3) ENSMUST00000145562.1 ENSMUST00000145562.2 ENSMUST00000145562.3 ENSMUST00000145562.4 ENSMUST00000145562.5 ENSMUST00000145562.6 ENSMUST00000145562.7 NR_015574 uc009mzf.1 uc009mzf.2 uc009mzf.1 uc009mzf.2 
ENSMUST00000145563.2 Gm13663 ENSMUST00000145563.2 Gm13663 (from geneSymbol) ENSMUST00000145563.1 uc289wvl.1 uc289wvl.2 uc289wvl.1 uc289wvl.2 
ENSMUST00000145568.2 Gm13467 ENSMUST00000145568.2 Gm13467 (from geneSymbol) ENSMUST00000145568.1 uc289vyu.1 uc289vyu.2 uc289vyu.1 uc289vyu.2 
ENSMUST00000145577.2 4930456L15Rik ENSMUST00000145577.2 RIKEN cDNA 4930456L15 gene (from RefSeq NR_045887.1) ENSMUST00000145577.1 NR_045887 uc029uyk.1 uc029uyk.2 uc029uyk.1 uc029uyk.2 
ENSMUST00000145579.2 Gm14093 ENSMUST00000145579.2 Gm14093 (from geneSymbol) ENSMUST00000145579.1 KY467905 uc290bbc.1 uc290bbc.2 uc290bbc.1 uc290bbc.2 
ENSMUST00000145584.2 Gm12154 ENSMUST00000145584.2 Gm12154 (from geneSymbol) ENSMUST00000145584.1 uc287xnz.1 uc287xnz.2 uc287xnz.1 uc287xnz.2 
ENSMUST00000145614.2 Mrps26 ENSMUST00000145614.2 mitochondrial ribosomal protein S26 (from RefSeq NM_207207.1) ENSMUST00000145614.1 NM_207207 Q80ZS3 RT26_MOUSE uc008mjf.1 uc008mjf.2 uc008mjf.3 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mS26 family. nucleoplasm mitochondrion mitochondrial small ribosomal subunit ribosome biological_process uc008mjf.1 uc008mjf.2 uc008mjf.3 
ENSMUST00000145652.2 Rab11fip4os1 ENSMUST00000145652.2 RAB11 family interacting protein 4 (class II), opposite strand 1 (from RefSeq NR_003283.1) ENSMUST00000145652.1 NR_003283 uc007kkv.1 uc007kkv.2 uc007kkv.1 uc007kkv.2 
ENSMUST00000145701.8 Inpp5e ENSMUST00000145701.8 inositol polyphosphate-5-phosphatase E, transcript variant 3 (from RefSeq NR_110957.1) ENSMUST00000145701.1 ENSMUST00000145701.2 ENSMUST00000145701.3 ENSMUST00000145701.4 ENSMUST00000145701.5 ENSMUST00000145701.6 ENSMUST00000145701.7 INP5E_MOUSE NR_110957 Q3TCC9 Q9JII1 uc008ivf.1 uc008ivf.2 uc008ivf.3 uc008ivf.4 Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Specific for lipid substrates, inactive towards water soluble inositol phosphates (By similarity) (PubMed:10806194). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (PubMed:19668215). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol 4-phosphate) + phosphate; Xref=Rhea:RHEA:22764, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456; EC=3.1.3.36; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22765; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + phosphate; Xref=Rhea:RHEA:25528, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57658, ChEBI:CHEBI:57836; EC=3.1.3.86; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25529; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3-phosphate) + phosphate; Xref=Rhea:RHEA:32955, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57923, ChEBI:CHEBI:58088; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32956; Evidence=; Interacts (when prenylated) with PDE6D; this is important for normal location in cilia. Cytoplasm, cytoskeleton, cilium axoneme Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, ruffle Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm Nucleus Note=Peripheral membrane protein associated with Golgi stacks. Highly expressed in testis, in pachytene and diplotene spermatocytes, but not in more mature elongating spermatids. Detected in neurons throughout the brain. Deficient mice display signs of ciliopathies including prenatal and perinatal lethality, polycystic kidneys, arrest of eye development, abnormalities in primary cilia, cerebral developmental defects, and skeletal defects. Belongs to the inositol polyphosphate 5-phosphatase family. Golgi membrane ruffle phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity cytoplasm Golgi apparatus cytoskeleton plasma membrane cilium axoneme lipid metabolic process negative regulation of phosphatidylinositol 3-kinase signaling membrane phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity hydrolase activity negative regulation of translation Golgi cisterna membrane cell projection phosphatidylinositol metabolic process inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation negative regulation of protein localization to cilium uc008ivf.1 uc008ivf.2 uc008ivf.3 uc008ivf.4 
ENSMUST00000145722.2 Gm14684 ENSMUST00000145722.2 Gm14684 (from geneSymbol) ENSMUST00000145722.1 uc292opp.1 uc292opp.2 uc292opp.1 uc292opp.2 
ENSMUST00000145751.2 Gm12629 ENSMUST00000145751.2 Gm12629 (from geneSymbol) ENSMUST00000145751.1 uc290nsr.1 uc290nsr.2 uc290nsr.1 uc290nsr.2 
ENSMUST00000145789.2 Gm11999 ENSMUST00000145789.2 predicted gene 11999 (from RefSeq NR_166812.1) ENSMUST00000145789.1 NR_166812 uc057kkh.1 uc057kkh.2 uc057kkh.1 uc057kkh.2 
ENSMUST00000145790.2 Gm15397 ENSMUST00000145790.2 Gm15397 (from geneSymbol) ENSMUST00000145790.1 uc287scp.1 uc287scp.2 uc287scp.1 uc287scp.2 
ENSMUST00000145798.4 Vinac1 ENSMUST00000145798.4 vinculin/alpha-catenin family member 1 (from RefSeq NM_001370941.1) A2AP89 A2AP89_MOUSE ENSMUST00000145798.1 ENSMUST00000145798.2 ENSMUST00000145798.3 Gm14025 NM_001370941 Vinac1 uc290aiz.1 uc290aiz.2 Belongs to the vinculin/alpha-catenin family. molecular_function cellular_component cell adhesion biological_process cadherin binding actin filament binding uc290aiz.1 uc290aiz.2 
ENSMUST00000145800.2 Gm14640 ENSMUST00000145800.2 Gm14640 (from geneSymbol) ENSMUST00000145800.1 uc290cwz.1 uc290cwz.2 uc290cwz.1 uc290cwz.2 
ENSMUST00000145865.4 4930442L01Rik ENSMUST00000145865.4 RIKEN cDNA 4930442L01 gene (from RefSeq NR_015596.1) ENSMUST00000145865.1 ENSMUST00000145865.2 ENSMUST00000145865.3 NR_015596 uc008qoh.1 uc008qoh.2 uc008qoh.3 uc008qoh.4 uc008qoh.1 uc008qoh.2 uc008qoh.3 uc008qoh.4 
ENSMUST00000145871.3 F730035M05Rik ENSMUST00000145871.3 RIKEN cDNA F730035M05 gene (from RefSeq NR_045174.1) ENSMUST00000145871.1 ENSMUST00000145871.2 NR_045174 uc007ntn.1 uc007ntn.2 uc007ntn.1 uc007ntn.2 
ENSMUST00000145893.2 Gm15471 ENSMUST00000145893.2 predicted gene 15471 (from RefSeq NR_040412.1) ENSMUST00000145893.1 NR_040412 uc029uny.1 uc029uny.2 uc029uny.3 uc029uny.1 uc029uny.2 uc029uny.3 
ENSMUST00000145894.3 Gm14703 ENSMUST00000145894.3 predicted gene 14703 (from RefSeq NR_189035.1) ENSMUST00000145894.1 ENSMUST00000145894.2 NR_189035 uc292mxx.1 uc292mxx.2 uc292mxx.3 uc292mxx.1 uc292mxx.2 uc292mxx.3 
ENSMUST00000145897.2 ENSMUSG00000121495 ENSMUST00000145897.2 ENSMUSG00000121495 (from geneSymbol) ENSMUST00000145897.1 uc290wos.1 uc290wos.2 uc290wos.1 uc290wos.2 
ENSMUST00000145909.9 Gm49397 ENSMUST00000145909.9 Gm49397 (from geneSymbol) AK048440 ENSMUST00000145909.1 ENSMUST00000145909.2 ENSMUST00000145909.3 ENSMUST00000145909.4 ENSMUST00000145909.5 ENSMUST00000145909.6 ENSMUST00000145909.7 ENSMUST00000145909.8 uc288xri.1 uc288xri.2 uc288xri.1 uc288xri.2 
ENSMUST00000145910.9 Strn ENSMUST00000145910.9 striatin, calmodulin binding protein, transcript variant 1 (from RefSeq NM_011500.3) B2RWV9 ENSMUST00000145910.1 ENSMUST00000145910.2 ENSMUST00000145910.3 ENSMUST00000145910.4 ENSMUST00000145910.5 ENSMUST00000145910.6 ENSMUST00000145910.7 ENSMUST00000145910.8 NM_011500 O55106 Q5BKR9 STRN_MOUSE uc008dpa.1 uc008dpa.2 uc008dpa.3 Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity). Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, dendritic spine Note=CTTNBP2-binding may regulate dendritic spine distribution. Mainly expressed in brain but is also expressed at low levels in various tissues such as kidney, spleen, skeletal muscle and lung. Belongs to the WD repeat striatin family. calmodulin binding cytoplasm bicellular tight junction locomotory behavior negative regulation of cell proliferation postsynaptic density membrane Wnt signaling pathway dendrite development protein domain specific binding estrogen receptor binding dendrite macromolecular complex cell projection neuronal cell body dendritic spine macromolecular complex binding postsynaptic membrane protein phosphatase 2A binding armadillo repeat domain binding FAR/SIN/STRIPAK complex uc008dpa.1 uc008dpa.2 uc008dpa.3 
ENSMUST00000145914.2 Gm15478 ENSMUST00000145914.2 Gm15478 (from geneSymbol) AK048962 ENSMUST00000145914.1 uc290wcm.1 uc290wcm.2 uc290wcm.1 uc290wcm.2 
ENSMUST00000145916.2 Gm15298 ENSMUST00000145916.2 Gm15298 (from geneSymbol) ENSMUST00000145916.1 uc292qwa.1 uc292qwa.2 uc292qwa.1 uc292qwa.2 
ENSMUST00000145924.2 Gm15597 ENSMUST00000145924.2 Gm15597 (from geneSymbol) AK144031 ENSMUST00000145924.1 uc289ivq.1 uc289ivq.2 uc289ivq.1 uc289ivq.2 
ENSMUST00000145926.2 4631405J19Rik ENSMUST00000145926.2 4631405J19Rik (from geneSymbol) BC100298 ENSMUST00000145926.1 uc289yos.1 uc289yos.2 uc289yos.1 uc289yos.2 
ENSMUST00000145950.3 Gm15864 ENSMUST00000145950.3 Gm15864 (from geneSymbol) ENSMUST00000145950.1 ENSMUST00000145950.2 uc291gah.1 uc291gah.2 uc291gah.3 uc291gah.1 uc291gah.2 uc291gah.3 
ENSMUST00000145963.9 Txnl4a ENSMUST00000145963.9 thioredoxin-like 4A, transcript variant 12 (from RefSeq NR_168915.1) Dim1 ENSMUST00000145963.1 ENSMUST00000145963.2 ENSMUST00000145963.3 ENSMUST00000145963.4 ENSMUST00000145963.5 ENSMUST00000145963.6 ENSMUST00000145963.7 ENSMUST00000145963.8 NR_168915 O14834 P83877 Q3TLI3 TXN4A_MOUSE Txnl4 uc008fso.1 uc008fso.2 uc008fso.3 uc008fso.4 Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). Component of the precatalytic spliceosome (spliceosome B complex). Component of the U5 snRNP complex. Component of the U4/U6-U5 tri-snRNP complex. The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Directly interacts with CD2BP2. Interacts with HNRPF, HNRPH2, NEDD9 and PQBP1. Interacts with ERBB4. Nucleus Belongs to the DIM1 family. mRNA splicing, via spliceosome molecular_function nucleus spliceosomal complex U5 snRNP cytoplasm cytosol mRNA processing cell cycle RNA splicing nuclear membrane U4/U6 x U5 tri-snRNP complex cell division U2-type precatalytic spliceosome uc008fso.1 uc008fso.2 uc008fso.3 uc008fso.4 
ENSMUST00000145973.3 Gm27191 ENSMUST00000145973.3 Gm27191 (from geneSymbol) ENSMUST00000145973.1 ENSMUST00000145973.2 uc292rdh.1 uc292rdh.2 uc292rdh.1 uc292rdh.2 
ENSMUST00000145988.9 Dnhd1 ENSMUST00000145988.9 dynein heavy chain domain 1 (from RefSeq NM_001370803.1) A0A8Z1SZM7 A0A8Z1SZM7_MOUSE Dnhd1 ENSMUST00000145988.1 ENSMUST00000145988.2 ENSMUST00000145988.3 ENSMUST00000145988.4 ENSMUST00000145988.5 ENSMUST00000145988.6 ENSMUST00000145988.7 ENSMUST00000145988.8 NM_001370803 uc009iyy.1 uc009iyy.2 uc009iyy.3 Belongs to the dynein heavy chain family. uc009iyy.1 uc009iyy.2 uc009iyy.3 
ENSMUST00000145993.9 Gm52968 ENSMUST00000145993.9 Gm52968 (from geneSymbol) A0A668KLD9 A0A668KLD9_MOUSE AB117943 ENSMUST00000145993.1 ENSMUST00000145993.2 ENSMUST00000145993.3 ENSMUST00000145993.4 ENSMUST00000145993.5 ENSMUST00000145993.6 ENSMUST00000145993.7 ENSMUST00000145993.8 Gm52968 uc289zss.1 uc289zss.2 uc289zss.1 uc289zss.2 
ENSMUST00000145994.3 Gm13595 ENSMUST00000145994.3 Gm13595 (from geneSymbol) ENSMUST00000145994.1 ENSMUST00000145994.2 uc289wmr.1 uc289wmr.2 uc289wmr.3 uc289wmr.1 uc289wmr.2 uc289wmr.3 
ENSMUST00000146016.2 Gm11750 ENSMUST00000146016.2 Gm11750 (from geneSymbol) ENSMUST00000146016.1 uc288dzu.1 uc288dzu.2 uc288dzu.1 uc288dzu.2 
ENSMUST00000146034.2 Gm13582 ENSMUST00000146034.2 predicted gene 13582 (from RefSeq NR_045335.1) ENSMUST00000146034.1 NR_045335 uc029txr.1 uc029txr.2 uc029txr.1 uc029txr.2 
ENSMUST00000146040.9 Atxn7l1 ENSMUST00000146040.9 ataxin 7-like 1, transcript variant 3 (from RefSeq NM_001374022.1) Atxn7l1 ENSMUST00000146040.1 ENSMUST00000146040.2 ENSMUST00000146040.3 ENSMUST00000146040.4 ENSMUST00000146040.5 ENSMUST00000146040.6 ENSMUST00000146040.7 ENSMUST00000146040.8 F7C0E4 F7C0E4_MOUSE NM_001374022 uc288fwc.1 uc288fwc.2 uc288fwc.1 uc288fwc.2 
ENSMUST00000146088.8 Ttc38 ENSMUST00000146088.8 tetratricopeptide repeat domain 38, transcript variant 4 (from RefSeq NM_001416056.1) A3KMP2 ENSMUST00000146088.1 ENSMUST00000146088.2 ENSMUST00000146088.3 ENSMUST00000146088.4 ENSMUST00000146088.5 ENSMUST00000146088.6 ENSMUST00000146088.7 NM_001416056 Q05C02 Q05CK3 Q3UZU5 TTC38_MOUSE uc007xdo.1 uc007xdo.2 uc007xdo.3 uc007xdo.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A3KMP2-1; Sequence=Displayed; Name=2; IsoId=A3KMP2-2; Sequence=VSP_031791; Belongs to the TTC38 family. Sequence=AAH24550.1; Type=Erroneous initiation; Evidence=; Sequence=AAH30849.1; Type=Erroneous initiation; Evidence=; molecular_function biological_process uc007xdo.1 uc007xdo.2 uc007xdo.3 uc007xdo.4 
ENSMUST00000146094.2 Fhad1os1 ENSMUST00000146094.2 forkhead-associated phosphopeptide binding domain 1, opposite strand 1 (from RefSeq NR_040672.1) ENSMUST00000146094.1 NR_040672 uc029vai.1 uc029vai.2 uc029vai.1 uc029vai.2 
ENSMUST00000146100.8 Fcho1 ENSMUST00000146100.8 Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation. Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation. (from UniProt Q8K285) AK137333 D3Z3Q5 ENSMUST00000146100.1 ENSMUST00000146100.2 ENSMUST00000146100.3 ENSMUST00000146100.4 ENSMUST00000146100.5 ENSMUST00000146100.6 ENSMUST00000146100.7 FCHO1_MOUSE Fcho1 Q8K285 uc292axn.1 uc292axn.2 Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation. Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation. May oligomerize and form homotetramer (PubMed:21762413). Interacts with AP2A2 and AP2B1; 2 subunits of the adaptor protein complex AP-2 (PubMed:22484487). Interacts with DAB2. Interacts with clathrin (CLTC or CLTCL1). Interacts with EPS15, EPS15R and ITSN1. Interacts with AGFG1 and CALM. May interact with ACVR1; linking this receptor to clathrin-mediated endocytosis (By similarity). Q8K285; Q9CR95: Necap1; NbExp=2; IntAct=EBI-16078916, EBI-7592476; Membrane, clathrin-coated pit ; Peripheral membrane protein ; Cytoplasmic side Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to it may also dynamically associate with Golgi/TGN membranes. Mainly detected in brain and spleen. Belongs to the FCHO family. protein binding nucleoplasm cytoplasm cytosol cytoskeleton plasma membrane clathrin-coated pit endocytosis cytoskeletal protein binding membrane clathrin-coated vesicle AP-2 adaptor complex binding clathrin coat assembly clathrin-dependent endocytosis uc292axn.1 uc292axn.2 
ENSMUST00000146107.8 Tex22 ENSMUST00000146107.8 testis expressed gene 22, transcript variant 2 (from RefSeq NM_001361920.1) ENSMUST00000146107.1 ENSMUST00000146107.2 ENSMUST00000146107.3 ENSMUST00000146107.4 ENSMUST00000146107.5 ENSMUST00000146107.6 ENSMUST00000146107.7 NM_001361920 Q80ZP5 Q9D9U4 TEX22_MOUSE Tep22 uc288jqe.1 uc288jqe.2 Cytoplasm Cytoplasmic vesicle, secretory vesicle, acrosome Note=Localizes in the acrosomal region of early elongating spermatids. During late stages of elongating spermatids, no longer detected in the acrosomal region, while it mainly localizes in the cytoplasm. Incorporated into the midpiece of spermatids and is also present in the mitochondrial sheath of mature spermatozoa. Mainly expressed in spermatocytes and spermatids in testis. First detected in 18-day-old mice (at protein level). acrosomal vesicle molecular_function cytoplasm biological_process cytoplasmic vesicle uc288jqe.1 uc288jqe.2 
ENSMUST00000146110.2 Platr8 ENSMUST00000146110.2 pluripotency associated transcript 8 (from RefSeq NR_033473.1) ENSMUST00000146110.1 NR_033473 uc012cav.1 uc012cav.2 uc012cav.1 uc012cav.2 
ENSMUST00000146119.2 ENSMUSG00000121315 ENSMUST00000146119.2 ENSMUSG00000121315 (from geneSymbol) ENSMUST00000146119.1 uc291rac.1 uc291rac.2 uc291rac.1 uc291rac.2 
ENSMUST00000146121.3 Gm11292 ENSMUST00000146121.3 predicted gene 11292 (from RefSeq NR_188889.1) ENSMUST00000146121.1 ENSMUST00000146121.2 NR_188889 uc288lgr.1 uc288lgr.2 uc288lgr.1 uc288lgr.2 
ENSMUST00000146124.2 Gm17029 ENSMUST00000146124.2 Gm17029 (from geneSymbol) AK035651 ENSMUST00000146124.1 uc033igt.1 uc033igt.2 uc033igt.1 uc033igt.2 
ENSMUST00000146132.2 Gm16235 ENSMUST00000146132.2 Gm16235 (from geneSymbol) ENSMUST00000146132.1 uc287txe.1 uc287txe.2 uc287txe.1 uc287txe.2 
ENSMUST00000146134.2 Gm13920 ENSMUST00000146134.2 Gm13920 (from geneSymbol) AK039323 ENSMUST00000146134.1 uc289ytw.1 uc289ytw.2 uc289ytw.1 uc289ytw.2 
ENSMUST00000146150.3 Gpr137c ENSMUST00000146150.3 G protein-coupled receptor 137C (from RefSeq NM_027518.2) E9Q343 ENSMUST00000146150.1 ENSMUST00000146150.2 G137C_MOUSE Gpr137c NM_027518 uc007tgl.1 uc007tgl.2 uc007tgl.3 uc007tgl.4 Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. Lysosome membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007tgl.1 uc007tgl.2 uc007tgl.3 uc007tgl.4 
ENSMUST00000146152.3 Gm16225 ENSMUST00000146152.3 Gm16225 (from geneSymbol) ENSMUST00000146152.1 ENSMUST00000146152.2 uc290qus.1 uc290qus.2 uc290qus.3 uc290qus.1 uc290qus.2 uc290qus.3 
ENSMUST00000146165.8 D3Ertd751e ENSMUST00000146165.8 DNA segment, Chr 3, ERATO Doi 751, expressed, transcript variant 1 (from RefSeq NM_028667.3) CD033_MOUSE ENSMUST00000146165.1 ENSMUST00000146165.2 ENSMUST00000146165.3 ENSMUST00000146165.4 ENSMUST00000146165.5 ENSMUST00000146165.6 ENSMUST00000146165.7 NM_028667 Q8BGN2 Q8C8S9 Q9CZE4 Q9D5M7 uc008pcr.1 uc008pcr.2 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGN2-1; Sequence=Displayed; Name=2; IsoId=Q8BGN2-2; Sequence=VSP_027013; Belongs to the UPF0462 family. molecular_function cellular_component biological_process uc008pcr.1 uc008pcr.2 
ENSMUST00000146205.3 Malrd1 ENSMUST00000146205.3 MAM and LDL receptor class A domain containing 1 (from RefSeq NM_001310455.1) A2AJX4 Diet1 ENSMUST00000146205.1 ENSMUST00000146205.2 Gm13318 MALR1_MOUSE Malrd1 NM_001310455 R9W764 uc033hll.1 uc033hll.2 uc033hll.3 Enhances production and/or transport of FGF15 and thus has a role in regulation of bile acid synthesis. Interacts with FGF15. Cytoplasmic vesicle membrane ; Single-pass type I membrane protein Strongly expressed in epithelial cells of the small intestine. Also detected in kidney cortex, and testis. Viable, with enhanced resistance to diet-induced hypercholesterolemia and atherosclerosis (PubMed:10744778). Increased bile acid levels in blood, liver and gastrointestinal tract, associated with significantly reduced levels of FGF15 in the ileum (PubMed:23747249). protein binding cytoplasm Golgi apparatus membrane integral component of membrane cytoplasmic vesicle membrane cytoplasmic vesicle cholesterol homeostasis negative regulation of bile acid biosynthetic process uc033hll.1 uc033hll.2 uc033hll.3 
ENSMUST00000146218.2 Gm12735 ENSMUST00000146218.2 Gm12735 (from geneSymbol) ENSMUST00000146218.1 KY467561 uc057kke.1 uc057kke.2 uc057kke.1 uc057kke.2 
ENSMUST00000146222.2 Gm15342 ENSMUST00000146222.2 Gm15342 (from geneSymbol) AK133374 ENSMUST00000146222.1 uc289glq.1 uc289glq.2 uc289glq.1 uc289glq.2 
ENSMUST00000146224.2 Gm14339 ENSMUST00000146224.2 Gm14339 (from geneSymbol) ENSMUST00000146224.1 uc290dki.1 uc290dki.2 uc290dki.1 uc290dki.2 
ENSMUST00000146232.2 Gm21982 ENSMUST00000146232.2 Gm21982 (from geneSymbol) AK088692 ENSMUST00000146232.1 uc291nzj.1 uc291nzj.2 uc291nzj.1 uc291nzj.2 
ENSMUST00000146233.8 Xaf1 ENSMUST00000146233.8 XIAP associated factor 1, transcript variant 1 (from RefSeq NM_001037713.4) B7ZD14 Birc4bp ENSMUST00000146233.1 ENSMUST00000146233.2 ENSMUST00000146233.3 ENSMUST00000146233.4 ENSMUST00000146233.5 ENSMUST00000146233.6 ENSMUST00000146233.7 NM_001037713 Q3USK3 Q5NBU6 Q5NBU7 Q5NBU8 Q5NBU9 XAF1_MOUSE Xiapaf1 uc011xyi.1 uc011xyi.2 uc011xyi.3 Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity). Interacts with BIRC1, BIRC2, BIRC3, BIRC4, BIRC7 and BIRC8. Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation. Interacts with RNF114, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling (By similarity). Cytoplasm Nucleus Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5NBU8-1; Sequence=Displayed; Name=2; IsoId=Q5NBU8-3; Sequence=VSP_039715; Sequence=BAE24328.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Sequence=CAI36034.1; Type=Erroneous gene model prediction; Evidence=; nucleus cytoplasm mitochondrion apoptotic process negative regulation of protein complex assembly response to interferon-beta metal ion binding uc011xyi.1 uc011xyi.2 uc011xyi.3 
ENSMUST00000146258.2 Itgb3bp ENSMUST00000146258.2 integrin beta 3 binding protein (beta3-endonexin), transcript variant 1 (from RefSeq NM_026348.4) CENPR_MOUSE Cenpr ENSMUST00000146258.1 NM_026348 Nrif3 Q3TLR0 Q3TNR4 Q9CQ82 uc008tux.1 uc008tux.2 uc008tux.3 Transcription coregulator that can have both coactivator and corepressor functions. Involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand- dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity). Homodimer; mediated by the coiled coil domain. Interacts with CCNA2 and MTA1. Interacts with NFKB1 NF-kappa-B subunit. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA- NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity). Interacts with TASOR (PubMed:31112734). Nucleus Chromosome, centromere Chromosome, centromere, kinetochore Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQ82-1; Sequence=Displayed; Name=2; IsoId=Q9CQ82-2; Sequence=VSP_020453, VSP_020454; Expressed in the spermatogonia and spermatocytes. The DD1 domain (also called RepD1 domain) mediates the corepressor function and is essential in the triggering of apoptosis. Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, which is essential for the association with nuclear receptors. chromosome, centromeric region kinetochore condensed chromosome kinetochore molecular_function nucleus nucleoplasm chromosome regulation of transcription, DNA-templated apoptotic process cell cycle CENP-A containing nucleosome assembly cell division uc008tux.1 uc008tux.2 uc008tux.3 
ENSMUST00000146269.3 Gm12781 ENSMUST00000146269.3 Gm12781 (from geneSymbol) ENSMUST00000146269.1 ENSMUST00000146269.2 KY468130 uc057ltt.1 uc057ltt.2 uc057ltt.3 uc057ltt.1 uc057ltt.2 uc057ltt.3 
ENSMUST00000146292.8 Tmem63c ENSMUST00000146292.8 transmembrane protein 63c, transcript variant 4 (from RefSeq NM_001361705.1) CSC1 CSC1_MOUSE ENSMUST00000146292.1 ENSMUST00000146292.2 ENSMUST00000146292.3 ENSMUST00000146292.4 ENSMUST00000146292.5 ENSMUST00000146292.6 ENSMUST00000146292.7 NM_001361705 Q8CBX0 uc007oih.1 uc007oih.2 uc007oih.3 uc007oih.4 Acts as an osmosensitive calcium-permeable cation channel (PubMed:27045885). Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). Cell membrane ; Multi-pass membrane protein Belongs to the CSC1 (TC 1.A.17) family. calcium activated cation channel activity plasma membrane ion transport cation transport membrane integral component of membrane ion transmembrane transport uc007oih.1 uc007oih.2 uc007oih.3 uc007oih.4 
ENSMUST00000146299.8 Gm20547 ENSMUST00000146299.8 Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. (from UniProt B8JJN0) AK149531 B8JJN0 B8JJN0_MOUSE C2 ENSMUST00000146299.1 ENSMUST00000146299.2 ENSMUST00000146299.3 ENSMUST00000146299.4 ENSMUST00000146299.5 ENSMUST00000146299.6 ENSMUST00000146299.7 Gm20547 uc289khu.1 uc289khu.2 Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. Reaction=Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b.; EC=3.4.21.43; Evidence=; Secreted Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc289khu.1 uc289khu.2 
ENSMUST00000146314.2 Gm15832 ENSMUST00000146314.2 Gm15832 (from geneSymbol) AK040602 ENSMUST00000146314.1 uc007atk.1 uc007atk.2 uc007atk.3 uc007atk.1 uc007atk.2 uc007atk.3 
ENSMUST00000146320.4 Gm15318 ENSMUST00000146320.4 Gm15318 (from geneSymbol) AK050258 ENSMUST00000146320.1 ENSMUST00000146320.2 ENSMUST00000146320.3 uc008bun.1 uc008bun.2 uc008bun.3 uc008bun.4 uc008bun.1 uc008bun.2 uc008bun.3 uc008bun.4 
ENSMUST00000146326.8 Gm15587 ENSMUST00000146326.8 Gm15587 (from geneSymbol) AK138592 ENSMUST00000146326.1 ENSMUST00000146326.2 ENSMUST00000146326.3 ENSMUST00000146326.4 ENSMUST00000146326.5 ENSMUST00000146326.6 ENSMUST00000146326.7 uc008wre.1 uc008wre.2 uc008wre.1 uc008wre.2 
ENSMUST00000146346.4 Gm12829 ENSMUST00000146346.4 Gm12829 (from geneSymbol) AK050995 ENSMUST00000146346.1 ENSMUST00000146346.2 ENSMUST00000146346.3 uc290oub.1 uc290oub.2 uc290oub.3 uc290oub.4 uc290oub.1 uc290oub.2 uc290oub.3 uc290oub.4 
ENSMUST00000146372.3 Gm12160 ENSMUST00000146372.3 Gm12160 (from geneSymbol) AK144274 ENSMUST00000146372.1 ENSMUST00000146372.2 uc007ino.1 uc007ino.2 uc007ino.3 uc007ino.4 uc007ino.1 uc007ino.2 uc007ino.3 uc007ino.4 
ENSMUST00000146390.3 Sstr2 ENSMUST00000146390.3 somatostatin receptor 2, transcript variant 1 (from RefSeq NM_001042606.3) ENSMUST00000146390.1 ENSMUST00000146390.2 NM_001042606 P30875 P30934 Q91Y73 SSR2_MOUSE Smstr2 Sst2 uc011yha.1 uc011yha.2 uc011yha.3 uc011yha.4 The protein encoded by this gene is a receptor for somatostatin, which acts at many sites to inhibit the release of several hormones and other secretory proteins. The encoded protein is a member of the superfamily of receptors having seven transmembrane segments and is involved in many processes, including adenylyl cyclase inhibition, phosphotyrosine phosphatase stimulation, and inhibition of calcium entry and cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7652917.962482.1, SRR7345562.4443427.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C- terminus) with SHANK1 (via PDZ domain) (By similarity). Cell membrane ; Multi-pass membrane protein Cytoplasm Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm (By similarity). Event=Alternative splicing; Named isoforms=2; Name=A; Synonyms=SS2RA; IsoId=P30875-1; Sequence=Displayed; Name=B; Synonyms=SS2RB; IsoId=P30875-2; Sequence=VSP_001923; Cerebrum and kidney. Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity somatostatin receptor activity cytoplasm cytosol plasma membrane integral component of plasma membrane regulation of muscle contraction signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway neuropeptide signaling pathway spermatogenesis membrane integral component of membrane cerebellum development PDZ domain binding peristalsis forebrain development somatostatin signaling pathway peptide binding response to starvation neuropeptide binding cellular response to glucocorticoid stimulus cellular response to estradiol stimulus uc011yha.1 uc011yha.2 uc011yha.3 uc011yha.4 
ENSMUST00000146409.8 Slc26a2 ENSMUST00000146409.8 solute carrier family 26 (sulfate transporter), member 2 (from RefSeq NM_007885.2) Dtd Dtdst ENSMUST00000146409.1 ENSMUST00000146409.2 ENSMUST00000146409.3 ENSMUST00000146409.4 ENSMUST00000146409.5 ENSMUST00000146409.6 ENSMUST00000146409.7 NM_007885 Q543D6 Q62273 Q8R2L9 S26A2_MOUSE uc008fbu.1 uc008fbu.2 uc008fbu.3 Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (PubMed:24302720). Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions (PubMed:20219950, PubMed:22190686, PubMed:24302720). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (PubMed:22190686). Essential for chondrocyte proliferation, differentiation and cell size expansion (PubMed:24302720). Reaction=oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in); Xref=Rhea:RHEA:72275, ChEBI:CHEBI:16189, ChEBI:CHEBI:30623; Evidence=; Reaction=2 chloride(in) + sulfate(out) = 2 chloride(out) + sulfate(in); Xref=Rhea:RHEA:75091, ChEBI:CHEBI:16189, ChEBI:CHEBI:17996; Evidence= Reaction=2 chloride(in) + oxalate(out) = 2 chloride(out) + oxalate(in); Xref=Rhea:RHEA:75095, ChEBI:CHEBI:17996, ChEBI:CHEBI:30623; Evidence=; Reaction=bromide(in) + chloride(out) = bromide(out) + chloride(in); Xref=Rhea:RHEA:75335, ChEBI:CHEBI:15858, ChEBI:CHEBI:17996; Evidence=; Reaction=chloride(out) + nitrate(in) = chloride(in) + nitrate(out); Xref=Rhea:RHEA:75339, ChEBI:CHEBI:17632, ChEBI:CHEBI:17996; Evidence=; Reaction=chloride(out) + iodide(in) = chloride(in) + iodide(out); Xref=Rhea:RHEA:72379, ChEBI:CHEBI:16382, ChEBI:CHEBI:17996; Evidence=; Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Distributed mainly in the thymus, testis and osteoblastic cells (PubMed:9370300). Highly expressed in the bone, cartilage, kidney and colon (PubMed:24302720). N-glycosylated. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. ossification plasma membrane integral component of plasma membrane ion transport secondary active sulfate transmembrane transporter activity sulfate transport bicarbonate transmembrane transporter activity chloride transmembrane transporter activity sulfate transmembrane transporter activity anion:anion antiporter activity bicarbonate transport membrane integral component of membrane apical plasma membrane oxalate transmembrane transporter activity oxalate transport microvillus membrane transmembrane transport sulfate transmembrane transport chloride transmembrane transport uc008fbu.1 uc008fbu.2 uc008fbu.3 
ENSMUST00000146411.9 Asgr1 ENSMUST00000146411.9 asialoglycoprotein receptor 1, transcript variant 2 (from RefSeq NM_001291131.1) ASGR1_MOUSE Asgr-1 ENSMUST00000146411.1 ENSMUST00000146411.2 ENSMUST00000146411.3 ENSMUST00000146411.4 ENSMUST00000146411.5 ENSMUST00000146411.6 ENSMUST00000146411.7 ENSMUST00000146411.8 NM_001291131 P34927 Q64363 Q91Y84 uc056ymb.1 uc056ymb.2 uc056ymb.3 Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. Interacts with LASS2. Membrane; Single-pass type II membrane protein. Expressed exclusively in hepatic parenchymal cells. Phosphorylated on a cytoplasmic Ser residue. Calcium is required for ligand binding. Name=Functional Glycomics Gateway - Glycan Binding; Note=Hepatic asialoglycoprotein receptor subunit 1; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_162"; asialoglycoprotein receptor activity endocytosis membrane integral component of membrane carbohydrate binding cellular response to extracellular stimulus protein homodimerization activity metal ion binding uc056ymb.1 uc056ymb.2 uc056ymb.3 
ENSMUST00000146417.9 Fam47e ENSMUST00000146417.9 family with sequence similarity 47, member E, transcript variant 3 (from RefSeq NM_001374714.1) D3YWC7 D3YWC7_MOUSE ENSMUST00000146417.1 ENSMUST00000146417.2 ENSMUST00000146417.3 ENSMUST00000146417.4 ENSMUST00000146417.5 ENSMUST00000146417.6 ENSMUST00000146417.7 ENSMUST00000146417.8 Fam47e NM_001374714 uc290xcu.1 uc290xcu.2 Belongs to the FAM47 family. molecular_function cytoplasm biological_process uc290xcu.1 uc290xcu.2 
ENSMUST00000146444.8 Tab2 ENSMUST00000146444.8 TGF-beta activated kinase 1/MAP3K7 binding protein 2, transcript variant 1 (from RefSeq NM_138667.3) ENSMUST00000146444.1 ENSMUST00000146444.2 ENSMUST00000146444.3 ENSMUST00000146444.4 ENSMUST00000146444.5 ENSMUST00000146444.6 ENSMUST00000146444.7 Kiaa0733 Map3k7ip2 NM_138667 Q3UGP1 Q8BTP4 Q8CHD3 Q99K90 Q99KP4 TAB2_MOUSE uc007eir.1 uc007eir.2 uc007eir.3 uc007eir.4 Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (By similarity). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys- 63'-linked polyubiquitin chains (By similarity). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:19927120). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (PubMed:12150997). Involved in heart development (By similarity). Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains (By similarity). Interacts with NCOR1 and HDAC3 to form a ternary complex (PubMed:12150997). Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with DYNC2I2 (via WD domains). Interacts with RBCK1. Interacts with TRIM5 (By similarity). Interacts with TRIM38 (via B30.2/SPRY domain), leading to its translocation to lysosomes and degradation (By similarity). Q99K90; Q62073: Map3k7; NbExp=8; IntAct=EBI-1775124, EBI-1775345; Q99K90; P62991: Ubc; NbExp=9; IntAct=EBI-1775124, EBI-413074; Membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Lysosome membrane ; Peripheral membrane protein Cytoplasm, cytosol Nucleus Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol. Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome. Widely expressed. The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins. SUMOylated by TRIM60; leading to inhibition of MAPK/NF-kappaB activation and the innate immune response. Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation. Ubiquitinated at Lys-611 by TRIM45 leading to proteasomal degradation. Degraded in a lysosome-dependent manner following interaction with TRIM38. Phosphorylated. Sequence=BAC40772.1; Type=Frameshift; Evidence=; protein binding nucleus nucleoplasm cytoplasm cytosol heart development response to lipopolysaccharide positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein kinase activity metal ion binding K63-linked polyubiquitin binding uc007eir.1 uc007eir.2 uc007eir.3 uc007eir.4 
ENSMUST00000146511.8 Gtf3a ENSMUST00000146511.8 general transcription factor III A (from RefSeq NM_025652.3) ENSMUST00000146511.1 ENSMUST00000146511.2 ENSMUST00000146511.3 ENSMUST00000146511.4 ENSMUST00000146511.5 ENSMUST00000146511.6 ENSMUST00000146511.7 NM_025652 Q8BJ79 Q8K270 Q8VHT7 Q9CSH8 TF3A_MOUSE uc009ano.1 uc009ano.2 uc009ano.3 uc009ano.4 The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AF391799.1, AK008247.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III- dependent transcription and may also maintain the transcription of other genes (By similarity). Also binds the transcribed 5S RNA's (By similarity). Nucleus It is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well conserved among mammals. Sequence=AAL69686.1; Type=Erroneous initiation; Evidence=; Sequence=BAB28476.2; Type=Erroneous initiation; Evidence=; Sequence=BAC25209.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding RNA binding nucleus regulation of transcription, DNA-templated 5S rRNA binding ribosome biogenesis ribosomal large subunit biogenesis metal ion binding uc009ano.1 uc009ano.2 uc009ano.3 uc009ano.4 
ENSMUST00000146532.2 Gm13070 ENSMUST00000146532.2 Gm13070 (from geneSymbol) ENSMUST00000146532.1 uc290rzm.1 uc290rzm.2 uc290rzm.1 uc290rzm.2 
ENSMUST00000146535.8 Gm14635 ENSMUST00000146535.8 predicted gene 14635 (from RefSeq NR_045321.1) ENSMUST00000146535.1 ENSMUST00000146535.2 ENSMUST00000146535.3 ENSMUST00000146535.4 ENSMUST00000146535.5 ENSMUST00000146535.6 ENSMUST00000146535.7 NR_045321 uc009sqw.1 uc009sqw.2 uc009sqw.3 uc009sqw.4 uc009sqw.1 uc009sqw.2 uc009sqw.3 uc009sqw.4 
ENSMUST00000146550.2 Gm11680 ENSMUST00000146550.2 Gm11680 (from geneSymbol) ENSMUST00000146550.1 uc288dgh.1 uc288dgh.2 uc288dgh.1 uc288dgh.2 
ENSMUST00000146576.2 Gm12503 ENSMUST00000146576.2 prothymosin alpha, pseudogene 2, transcript variant 4 (from RefSeq NR_188935.1) ENSMUST00000146576.1 NR_188935 uc290mis.1 uc290mis.2 uc290mis.1 uc290mis.2 
ENSMUST00000146590.8 Dnajb12 ENSMUST00000146590.8 DnaJ heat shock protein family (Hsp40) member B12, transcript variant 2 (from RefSeq NM_019965.3) DJB12_MOUSE Dnajb12 ENSMUST00000146590.1 ENSMUST00000146590.2 ENSMUST00000146590.3 ENSMUST00000146590.4 ENSMUST00000146590.5 ENSMUST00000146590.6 ENSMUST00000146590.7 NM_019965 Q8K037 Q9QYI4 uc007fea.1 uc007fea.2 uc007fea.3 Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum- associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear. Homodimer and homotetramer. Interacts (via J domain) with HSPA8/Hsc70. Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct. Endoplasmic reticulum membrane ; Single-pass membrane protein Nucleus membrane ; Single- pass membrane protein Note=Localizes to the endoplasmic reticulum membrane. When overexpressed, forms membranous structures in the nucleus. Methylated at His-186 by METTL9. Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily. nucleus endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane integral component of endoplasmic reticulum membrane ER-associated ubiquitin-dependent protein catabolic process Hsp70 protein binding nuclear membrane cellular macromolecular complex assembly ERAD pathway chaperone mediated protein folding requiring cofactor cellular response to misfolded protein uc007fea.1 uc007fea.2 uc007fea.3 
ENSMUST00000146598.8 Ufm1 ENSMUST00000146598.8 ubiquitin-fold modifier 1 (from RefSeq NM_026435.5) ENSMUST00000146598.1 ENSMUST00000146598.2 ENSMUST00000146598.3 ENSMUST00000146598.4 ENSMUST00000146598.5 ENSMUST00000146598.6 ENSMUST00000146598.7 NM_026435 P61961 Q14346 Q3TLT0 Q542A7 Q9CPX2 Q9NZF2 UFM1_MOUSE Ufm1 uc008pfa.1 uc008pfa.2 uc008pfa.3 uc008pfa.4 Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer (PubMed:21494687). The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1- conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription (By similarity). Interacts with UBA5. Interacts with UFC1. Nucleus Cytoplasm Widely expressed with higher expression in secretory tissues (at protein level). Belongs to the UFM1 family. protein binding nucleus cytoplasm endoplasmic reticulum brain development regulation of intracellular estrogen receptor signaling pathway response to endoplasmic reticulum stress negative regulation of apoptotic process protein ufmylation protein K69-linked ufmylation uc008pfa.1 uc008pfa.2 uc008pfa.3 uc008pfa.4 
ENSMUST00000146623.8 Gpd1l ENSMUST00000146623.8 glycerol-3-phosphate dehydrogenase 1-like (from RefSeq NM_175380.5) ENSMUST00000146623.1 ENSMUST00000146623.2 ENSMUST00000146623.3 ENSMUST00000146623.4 ENSMUST00000146623.5 ENSMUST00000146623.6 ENSMUST00000146623.7 GPD1L_MOUSE Kiaa0089 NM_175380 Q3ULJ0 Q6A0D2 Q8BVZ7 Q8BWM5 Q8CFN6 uc009ryj.1 uc009ryj.2 uc009ryj.3 uc009ryj.4 Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3- phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. Reaction=NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH; Xref=Rhea:RHEA:11092, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57597, ChEBI:CHEBI:57642, ChEBI:CHEBI:57945; EC=1.1.1.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11093; Evidence=; Interacts with SCN5A. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3ULJ0-1; Sequence=Displayed; Name=2; IsoId=Q3ULJ0-2; Sequence=VSP_025062; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. Sequence=AAH37729.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAD32164.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; regulation of heart rate cytoplasm cytosol plasma membrane carbohydrate metabolic process glycerol-3-phosphate metabolic process NADH metabolic process glycerol-3-phosphate dehydrogenase complex positive regulation of sodium ion transport membrane oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor sodium channel regulator activity NAD metabolic process negative regulation of peptidyl-serine phosphorylation protein homodimerization activity ion channel binding glycerol-3-phosphate catabolic process NAD binding oxidation-reduction process regulation of ventricular cardiac muscle cell membrane depolarization ventricular cardiac muscle cell action potential negative regulation of protein kinase C signaling positive regulation of protein localization to cell surface regulation of sodium ion transmembrane transporter activity glycerol-3-phosphate dehydrogenase [NAD+] activity NADH oxidation uc009ryj.1 uc009ryj.2 uc009ryj.3 uc009ryj.4 
ENSMUST00000146644.2 Gm14827 ENSMUST00000146644.2 predicted gene 14827 (from RefSeq NR_045323.1) ENSMUST00000146644.1 NR_045323 uc029xlp.1 uc029xlp.2 uc029xlp.1 uc029xlp.2 
ENSMUST00000146654.3 Gm16348 ENSMUST00000146654.3 Gm16348 (from geneSymbol) AK050994 ENSMUST00000146654.1 ENSMUST00000146654.2 uc291zmo.1 uc291zmo.2 uc291zmo.3 uc291zmo.1 uc291zmo.2 uc291zmo.3 
ENSMUST00000146657.3 Gm16000 ENSMUST00000146657.3 Gm16000 (from geneSymbol) ENSMUST00000146657.1 ENSMUST00000146657.2 uc290gdd.1 uc290gdd.2 uc290gdd.3 uc290gdd.1 uc290gdd.2 uc290gdd.3 
ENSMUST00000146663.4 Gm17033 ENSMUST00000146663.4 Gm17033 (from geneSymbol) ENSMUST00000146663.1 ENSMUST00000146663.2 ENSMUST00000146663.3 uc288jaf.1 uc288jaf.2 uc288jaf.3 uc288jaf.1 uc288jaf.2 uc288jaf.3 
ENSMUST00000146673.3 Rtl10 ENSMUST00000146673.3 Rtl10 (from geneSymbol) BC029862 ENSMUST00000146673.1 ENSMUST00000146673.2 uc289deq.1 uc289deq.2 uc289deq.3 uc289deq.1 uc289deq.2 uc289deq.3 
ENSMUST00000146678.3 Wincr1 ENSMUST00000146678.3 WNT induced non-coding RNA 1 (from RefSeq NR_033533.1) ENSMUST00000146678.1 ENSMUST00000146678.2 NR_033533 uc008toe.1 uc008toe.2 uc008toe.3 uc008toe.4 uc008toe.5 uc008toe.1 uc008toe.2 uc008toe.3 uc008toe.4 uc008toe.5 
ENSMUST00000146688.3 Zfp989 ENSMUST00000146688.3 Nucleus (from UniProt H3BLB0) ENSMUST00000146688.1 ENSMUST00000146688.2 H3BLB0 H3BLB0_MOUSE Zfp989 uc290rrf.1 uc290rrf.2 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc290rrf.1 uc290rrf.2 
ENSMUST00000146690.2 Gm13485 ENSMUST00000146690.2 Gm13485 (from geneSymbol) ENSMUST00000146690.1 uc289wbk.1 uc289wbk.2 uc289wbk.1 uc289wbk.2 
ENSMUST00000146692.8 Tnfrsf22 ENSMUST00000146692.8 tumor necrosis factor receptor superfamily, member 22, transcript variant 1 (from RefSeq NM_023680.5) Dctrailr2 ENSMUST00000146692.1 ENSMUST00000146692.2 ENSMUST00000146692.3 ENSMUST00000146692.4 ENSMUST00000146692.5 ENSMUST00000146692.6 ENSMUST00000146692.7 NM_023680 Q8VHB9 Q9CZA4 Q9ER62 TNR22_MOUSE Tnfrh2 Tnfrsf1al2 uc009kps.1 uc009kps.2 uc009kps.3 uc009kps.4 Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis possibly through ligand competition. Cannot induce the NF-kappa-B pathway. [Isoform 1]: Cell membrane ; Single- pass type II membrane protein [Isoform 2]: Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ER62-1; Sequence=Displayed; Name=2; IsoId=Q9ER62-2; Sequence=VSP_007648; Ubiquitous. Sequence=BAB28502.2; Type=Erroneous initiation; Evidence=; Sequence=CAC16406.1; Type=Frameshift; Evidence=; Sequence=CAC27353.1; Type=Erroneous gene model prediction; Evidence=; protein binding extracellular region plasma membrane external side of plasma membrane cell surface membrane integral component of membrane TRAIL-activated apoptotic signaling pathway positive regulation of apoptotic process TRAIL binding negative regulation of extrinsic apoptotic signaling pathway via death domain receptors uc009kps.1 uc009kps.2 uc009kps.3 uc009kps.4 
ENSMUST00000146700.2 Gm15445 ENSMUST00000146700.2 Gm15445 (from geneSymbol) ENSMUST00000146700.1 uc287lyt.1 uc287lyt.2 uc287lyt.1 uc287lyt.2 
ENSMUST00000146702.2 9330198N18Rik ENSMUST00000146702.2 9330198N18Rik (from geneSymbol) AK020395 ENSMUST00000146702.1 uc289uua.1 uc289uua.2 uc289uua.1 uc289uua.2 
ENSMUST00000146704.2 Gm12600 ENSMUST00000146704.2 Gm12600 (from geneSymbol) ENSMUST00000146704.1 uc290nqk.1 uc290nqk.2 uc290nqk.1 uc290nqk.2 
ENSMUST00000146728.4 1700071G01Rik ENSMUST00000146728.4 1700071G01Rik (from geneSymbol) AK006930 ENSMUST00000146728.1 ENSMUST00000146728.2 ENSMUST00000146728.3 uc008xsq.1 uc008xsq.2 uc008xsq.3 uc008xsq.4 uc008xsq.1 uc008xsq.2 uc008xsq.3 uc008xsq.4 
ENSMUST00000146744.3 Tmcc3os ENSMUST00000146744.3 Tmcc3os (from geneSymbol) AK081028 ENSMUST00000146744.1 ENSMUST00000146744.2 uc287ugn.1 uc287ugn.2 uc287ugn.1 uc287ugn.2 
ENSMUST00000146746.2 4930444E06Rik ENSMUST00000146746.2 4930444E06Rik (from geneSymbol) AK015377 ENSMUST00000146746.1 uc290azd.1 uc290azd.2 uc290azd.1 uc290azd.2 
ENSMUST00000146751.2 Gm14963 ENSMUST00000146751.2 predicted gene 14963 (from RefSeq NR_168273.1) ENSMUST00000146751.1 NR_168273 uc008ghy.1 uc008ghy.2 uc008ghy.3 uc008ghy.1 uc008ghy.2 uc008ghy.3 
ENSMUST00000146755.2 Gm15945 ENSMUST00000146755.2 Gm15945 (from geneSymbol) BC067072 ENSMUST00000146755.1 uc288ytz.1 uc288ytz.2 uc288ytz.1 uc288ytz.2 
ENSMUST00000146766.2 Gm13833 ENSMUST00000146766.2 Gm13833 (from geneSymbol) ENSMUST00000146766.1 uc291dgx.1 uc291dgx.2 uc291dgx.1 uc291dgx.2 
ENSMUST00000146769.3 Gm13405 ENSMUST00000146769.3 Gm13405 (from geneSymbol) ENSMUST00000146769.1 ENSMUST00000146769.2 uc289uww.1 uc289uww.2 uc289uww.3 uc289uww.1 uc289uww.2 uc289uww.3 
ENSMUST00000146794.4 Prss45 ENSMUST00000146794.4 Secreted (from UniProt Q8K4I7) AF392062 ENSMUST00000146794.1 ENSMUST00000146794.2 ENSMUST00000146794.3 PRS45_MOUSE Prss45 Q3KNK7 Q8K4D1 Q8K4I7 Tessp5 uc009rux.1 uc009rux.2 uc009rux.3 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K4I7-1; Sequence=Displayed; Name=2; IsoId=Q8K4I7-2; Sequence=VSP_035356; Belongs to the peptidase S1 family. In contrast to other members of the family, lacks the conserved Ser at position 243 which is replaced by a Pro residue, suggesting it is inactive. serine-type endopeptidase activity extracellular region extracellular space proteolysis uc009rux.1 uc009rux.2 uc009rux.3 
ENSMUST00000146845.2 A530010F05Rik ENSMUST00000146845.2 A530010F05Rik (from geneSymbol) AK079928 ENSMUST00000146845.1 uc290acl.1 uc290acl.2 uc290acl.1 uc290acl.2 
ENSMUST00000146858.3 ENSMUSG00000121650 ENSMUST00000146858.3 ENSMUSG00000121650 (from geneSymbol) AK006943 ENSMUST00000146858.1 ENSMUST00000146858.2 uc009erm.1 uc009erm.2 uc009erm.3 uc009erm.4 uc009erm.1 uc009erm.2 uc009erm.3 uc009erm.4 
ENSMUST00000146887.2 Gm15731 ENSMUST00000146887.2 Gm15731 (from geneSymbol) AK084662 ENSMUST00000146887.1 uc290syg.1 uc290syg.2 uc290syg.1 uc290syg.2 
ENSMUST00000146905.2 Arl4a ENSMUST00000146905.2 ADP-ribosylation factor-like 4A, transcript variant 1 (from RefSeq NM_007487.3) ARL4A_MOUSE Arl4 ENSMUST00000146905.1 NM_007487 P41275 P61213 Q3TGR5 uc007nks.1 uc007nks.2 uc007nks.3 Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity). Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interact with ARL4A (By similarity). Cell membrane Cytoplasm Nucleus, nucleolus Note=Localization in the nucleolus is dependent by nucleotide binding. Expressed strongly in testis and liver. Expressed slightly in heart, spleen, lung and kidney. Expressed strongly in embryo at 7 dpc. Expressed slightly in embryo at 11, 15 and 17 dpc. Myristoylated. Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTPase activity GTP binding nucleus nucleoplasm nucleolus cytoplasm cytosol plasma membrane intracellular protein transport membrane vesicle-mediated transport brown fat cell differentiation uc007nks.1 uc007nks.2 uc007nks.3 
ENSMUST00000146909.2 Gm12367 ENSMUST00000146909.2 Gm12367 (from geneSymbol) AK045932 ENSMUST00000146909.1 uc008sgy.1 uc008sgy.2 uc008sgy.1 uc008sgy.2 
ENSMUST00000146915.2 9630013K17Rik ENSMUST00000146915.2 RIKEN cDNA 9630013K17 gene (from RefSeq NR_131111.1) ENSMUST00000146915.1 NR_131111 uc056ylo.1 uc056ylo.2 uc056ylo.1 uc056ylo.2 
ENSMUST00000146928.2 Gm15611 ENSMUST00000146928.2 Gm15611 (from geneSymbol) ENSMUST00000146928.1 KY468036 uc290tas.1 uc290tas.2 uc290tas.1 uc290tas.2 
ENSMUST00000146949.2 Gm15902 ENSMUST00000146949.2 Gm15902 (from geneSymbol) ENSMUST00000146949.1 uc288gej.1 uc288gej.2 uc288gej.1 uc288gej.2 
ENSMUST00000146954.2 Nr5a1os ENSMUST00000146954.2 Nr5a1os (from geneSymbol) AK017050 ENSMUST00000146954.1 uc289vtm.1 uc289vtm.2 uc289vtm.1 uc289vtm.2 
ENSMUST00000146963.2 Gm11464 ENSMUST00000146963.2 Gm11464 (from geneSymbol) ENSMUST00000146963.1 uc290cpl.1 uc290cpl.2 uc290cpl.1 uc290cpl.2 
ENSMUST00000146976.2 Gm12744 ENSMUST00000146976.2 Gm12744 (from geneSymbol) ENSMUST00000146976.1 uc290ogg.1 uc290ogg.2 uc290ogg.1 uc290ogg.2 
ENSMUST00000146978.3 Gm13869 ENSMUST00000146978.3 predicted gene 13869 (from RefSeq NR_166138.1) ENSMUST00000146978.1 ENSMUST00000146978.2 NR_166138 uc289yvc.1 uc289yvc.2 uc289yvc.3 uc289yvc.1 uc289yvc.2 uc289yvc.3 
ENSMUST00000146993.8 Mov10l1 ENSMUST00000146993.8 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; (from UniProt D3YWG8) AF285587 D3YWG8 D3YWG8_MOUSE ENSMUST00000146993.1 ENSMUST00000146993.2 ENSMUST00000146993.3 ENSMUST00000146993.4 ENSMUST00000146993.5 ENSMUST00000146993.6 ENSMUST00000146993.7 Mov10l1 uc289anc.1 uc289anc.2 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily. uc289anc.1 uc289anc.2 
ENSMUST00000147006.2 Gm11683 ENSMUST00000147006.2 Gm11683 (from geneSymbol) BC027544 ENSMUST00000147006.1 uc007mcz.1 uc007mcz.2 uc007mcz.1 uc007mcz.2 
ENSMUST00000147041.10 Arhgef38 ENSMUST00000147041.10 Rho guanine nucleotide exchange factor 38, transcript variant 1 (from RefSeq NM_001368752.1) ARH38_MOUSE E2QRQ2 ENSMUST00000147041.1 ENSMUST00000147041.2 ENSMUST00000147041.3 ENSMUST00000147041.4 ENSMUST00000147041.5 ENSMUST00000147041.6 ENSMUST00000147041.7 ENSMUST00000147041.8 ENSMUST00000147041.9 NM_001368752 Q80VK6 Q9D274 uc008rkk.1 uc008rkk.2 uc008rkk.3 May act as a guanine-nucleotide releasing factor. Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q80VK6-3; Sequence=Displayed; Name=1; IsoId=Q80VK6-1; Sequence=VSP_053831; Name=2; IsoId=Q80VK6-2; Sequence=VSP_031334, VSP_031335; guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cellular_component cytoplasm regulation of Rho protein signal transduction uc008rkk.1 uc008rkk.2 uc008rkk.3 
ENSMUST00000147045.2 Gm15082 ENSMUST00000147045.2 Gm15082 (from geneSymbol) AK087127 ENSMUST00000147045.1 uc291hwy.1 uc291hwy.2 uc291hwy.1 uc291hwy.2 
ENSMUST00000147064.8 Trim30e-ps1 ENSMUST00000147064.8 tripartite motif-containing 30E, pseudogene 1 (from RefSeq NR_033673.1) ENSMUST00000147064.1 ENSMUST00000147064.2 ENSMUST00000147064.3 ENSMUST00000147064.4 ENSMUST00000147064.5 ENSMUST00000147064.6 ENSMUST00000147064.7 NR_033673 uc009iwl.1 uc009iwl.2 uc009iwl.1 uc009iwl.2 
ENSMUST00000147128.2 Platr15 ENSMUST00000147128.2 Platr15 (from geneSymbol) ENSMUST00000147128.1 uc290bfz.1 uc290bfz.2 uc290bfz.1 uc290bfz.2 
ENSMUST00000147130.2 Gm14764 ENSMUST00000147130.2 Gm14764 (from geneSymbol) ENSMUST00000147130.1 uc292phl.1 uc292phl.2 uc292phl.1 uc292phl.2 
ENSMUST00000147141.2 Gm14264 ENSMUST00000147141.2 Gm14264 (from geneSymbol) AK081655 ENSMUST00000147141.1 uc290cww.1 uc290cww.2 uc290cww.1 uc290cww.2 
ENSMUST00000147142.3 Gm15020 ENSMUST00000147142.3 Gm15020 (from geneSymbol) ENSMUST00000147142.1 ENSMUST00000147142.2 uc292qoh.1 uc292qoh.2 uc292qoh.3 uc292qoh.1 uc292qoh.2 uc292qoh.3 
ENSMUST00000147147.8 Ehmt1 ENSMUST00000147147.8 euchromatic histone methyltransferase 1, transcript variant 1 (from RefSeq NM_001012518.3) A2AIS3 A2AIS4 EHMT1_MOUSE ENSMUST00000147147.1 ENSMUST00000147147.2 ENSMUST00000147147.3 ENSMUST00000147147.4 ENSMUST00000147147.5 ENSMUST00000147147.6 ENSMUST00000147147.7 Euhmtase1 Glp Kmt1d NM_001012518 Q5DW34 Q5EBR1 Q6PGM0 uc008ipi.1 uc008ipi.2 uc008ipi.3 uc008ipi.4 uc008ipi.5 uc008ipi.6 Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader Baz2b (PubMed:32103178). Reaction=N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60284, Rhea:RHEA-COMP:15541, Rhea:RHEA- COMP:15542, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; Reaction=L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60280, Rhea:RHEA-COMP:15542, Rhea:RHEA-COMP:15546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.367; Evidence=; Methyltransferase activity is inhibited by BIX- 01294. Efficiently inhibited by compound E72, a BIX-01294 derivative in which the diazepane ring and the benzyl are replaced with a 3- dimethylaminopropyl and a 5-aminopentyl group at sites B and C, respectively (By similarity). Interacts with WIZ. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EHMT1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with MPHOSPH8 (By similarity). Interacts with CDYL. Interacts with REST only in the presence of CDYL. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2 (By similarity). Heterodimer; heterodimerizes with EHMT2. Interacts (via ANK repeats) with RELA (when monomethylated at 'Lys- 310'). Interacts with Baz2b (PubMed:32103178). Interacts with MSX1 (PubMed:22629437). Q5DW34-1; A2A935-3: Prdm16; NbExp=2; IntAct=EBI-16080518, EBI-16080455; Nucleus Chromosome Note=Associates with euchromatic regions. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5DW34-1; Sequence=Displayed; Name=2; IsoId=Q5DW34-2; Sequence=VSP_040724, VSP_040725; Name=3; IsoId=Q5DW34-3; Sequence=VSP_040726; Ubiquitous. Expressed in the developing limb bud at 11.5 dpc (at protein level). The ANK repeats specifically recognize and bind H3K9me1 and H3K9me2 (By similarity). They also specifically recognize and bind RELA subunit of NF-kappa-B, when RELA is monomethylated at 'Lys-310'. The SET domain mediates interaction with WIZ. In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster. Embryos die around E9.5. Levels of H3K9me1 and H3K9me2 are drastically reduced. Belongs to the class V-like SAM-binding methyltransferase superfamily. Sequence=CAM22112.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter p53 binding protein binding nucleus nucleoplasm chromosome DNA methylation chromatin organization methyltransferase activity zinc ion binding protein-lysine N-methyltransferase activity histone methylation nuclear body transferase activity histone-lysine N-methyltransferase activity peptidyl-lysine monomethylation peptidyl-lysine dimethylation methylation histone lysine methylation negative regulation of transcription, DNA-templated regulation of embryonic development metal ion binding histone methyltransferase activity (H3-K9 specific) histone methyltransferase activity (H3-K27 specific) histone H3-K9 methylation response to fungicide histone H3-K27 methylation C2H2 zinc finger domain binding uc008ipi.1 uc008ipi.2 uc008ipi.3 uc008ipi.4 uc008ipi.5 uc008ipi.6 
ENSMUST00000147148.5 Smim20 ENSMUST00000147148.5 small integral membrane protein 20 (from RefSeq NM_001145433.1) D3Z7Q2 ENSMUST00000147148.1 ENSMUST00000147148.2 ENSMUST00000147148.3 ENSMUST00000147148.4 NM_001145433 SIM20_MOUSE Smim20 uc008xlg.1 uc008xlg.2 uc008xlg.3 uc008xlg.4 [Small integral membrane protein 20]: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (By similarity). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (By similarity). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (By similarity). [Phoenixin-14]: Peptide involved in a broad spectrum of regulatory functions (PubMed:25687846, PubMed:26505917, PubMed:27268078). Is a ligand for GPR173 (By similarity). As part of the reproductive cycle, it regulates gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus and pituitary gland which augments the release of luteinizing hormone (PubMed:27268078). More specifically, it regulates the expression of transcription factors CEBPB and POU2F1/OCT1 through the cAMP-PKA signaling pathway, which subsequently regulate the expression of GNRHR and KISS1 (PubMed:27268078). Plays a protective role in memory retention through activation of GNRHR (PubMed:26505917). Regulates the secretion of AVP by hypothalamic neurons (By similarity). Plays a role in the transduction of the itch sensation (PubMed:26415767). Induces anxiolytic effects, reducing behavior associated with anxiety (PubMed:25687846). Regulates food intake as well as satiation and satiety by increasing Nucb2 expression in neurons (By similarity). In the ovary, it regulates follicular growth by stimulating granulosa cell proliferation by increasing the expression of GPR173, CREB1, CYP19A1, KITLG, FSHR, and LHCGR (PubMed:30933929). It also increases the production of estradiol (E2) (PubMed:30933929). In the heart, it regulates contractility and relaxation by activating the AKT1-NOS3 and MAPK1-MAPK3 signaling pathways (By similarity). It also plays a cardioprotective role during ischemia, where it activates the SAFE and RISK pathways (By similarity). Stimulates the proliferation and differentiation of preadipocytes (PubMed:30251651). In pancreatic islet cells, it induces proliferation of islet cells as well as the production of INS through activation of the MAPK1-MAPK3 signaling pathways (PubMed:31422055). [Phoenixin-20]: Peptide involved in a broad spectrum of regulatory functions (PubMed:25687846, PubMed:26505917, PubMed:27268078). Is a ligand for GPR173 (By similarity). As part of the reproductive cycle, it regulates gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus and pituitary gland which augments the release of luteinizing hormone (PubMed:27268078). More specifically, it regulates the expression of transcription factors CEBPB and POU2F1/OCT1 through the cAMP-PKA signaling pathway, which subsequently regulate the expression of GNRHR and KISS1 (PubMed:27268078). Plays a protective role in memory retention through activation of GNRHR (PubMed:26505917). Regulates the secretion of AVP by hypothalamic neurons (By similarity). Plays a role in the transduction of the itch sensation (PubMed:26415767). Induces anxiolytic effects, reducing behavior associated with anxiety (PubMed:25687846). Regulates food intake as well as satiation and satiety by increasing Nucb2 expression in neurons (By similarity). In the ovary, it regulates follicular growth by stimulating granulosa cell proliferation by increasing the expression of GPR173, CREB1, CYP19A1, KITLG, FSHR, and LHCGR (PubMed:30933929). It also increases the production of estradiol (E2) (PubMed:30933929). In the heart, it regulates contractility and relaxation by activating the AKT1-NOS3 and MAPK1-MAPK3 signaling pathways (By similarity). It also plays a cardioprotective role during ischemia, where it activates the SAFE and RISK pathways (By similarity). Stimulates the proliferation and differentiation of preadipocytes (PubMed:30251651). In pancreatic islet cells, it induces proliferation of islet cells as well as the production of INS through activation of the MAPK1-MAPK3 signaling pathways (PubMed:31422055). Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14 (By similarity). Interacts with COA3/MITRAC12 and COX4I1 (By similarity). Directly interacts with newly synthesized MT-CO1/COX1 (By similarity). [Small integral membrane protein 20]: Mitochondrion inner membrane ; Single- pass membrane protein [Phoenixin-14]: Secreted [Phoenixin-20]: Secreted Highly expressed in the hypothalamus, the spinal cord, and sensory ganglia (at protein level) (PubMed:23912037, PubMed:26415767). Also expressed on in the epidermis and dermis layers of the skin (at protein level) (PubMed:26415767). Expressed in preadipocytes and adipocytes (at protein level) (PubMed:30251651). Expressed in the ovary, specifically in granulosa cells of follicles that have passed the primary stage and in oocytes (at protein level) (PubMed:30933929). By fatty acids, specifically palmitate, docosahexanoic acid and oleate. molecular_function mitochondrial inner membrane membrane integral component of membrane mitochondrial respiratory chain complex IV assembly uc008xlg.1 uc008xlg.2 uc008xlg.3 uc008xlg.4 
ENSMUST00000147153.4 Lipo2 ENSMUST00000147153.4 lipase, member O2 (from RefSeq NM_001322338.1) D3YY49 D3YY49_MOUSE ENSMUST00000147153.1 ENSMUST00000147153.2 ENSMUST00000147153.3 Lipo2 NM_001322338 uc057las.1 uc057las.2 uc057las.3 uc057las.4 Belongs to the AB hydrolase superfamily. Lipase family. sterol esterase activity lipid metabolic process lipid catabolic process sterol metabolic process hydrolase activity hydrolase activity, acting on ester bonds intracellular membrane-bounded organelle uc057las.1 uc057las.2 uc057las.3 uc057las.4 
ENSMUST00000147177.2 Pard3bos3 ENSMUST00000147177.2 Pard3bos3 (from geneSymbol) AK050209 ENSMUST00000147177.1 uc287iqp.1 uc287iqp.2 uc287iqp.1 uc287iqp.2 
ENSMUST00000147185.3 Ubap1l ENSMUST00000147185.3 ubiquitin-associated protein 1-like, transcript variant 2 (from RefSeq NM_001373909.1) ENSMUST00000147185.1 ENSMUST00000147185.2 G3UW59 G3UW59_MOUSE NM_001373909 Ubap1l uc012gvj.1 uc012gvj.2 uc012gvj.3 ESCRT I complex ubiquitin binding ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway uc012gvj.1 uc012gvj.2 uc012gvj.3 
ENSMUST00000147187.2 Gm14224 ENSMUST00000147187.2 Gm14224 (from geneSymbol) ENSMUST00000147187.1 uc290byb.1 uc290byb.2 uc290byb.1 uc290byb.2 
ENSMUST00000147196.3 Mtres1 ENSMUST00000147196.3 mitochondrial transcription rescue factor 1 (from RefSeq NM_026411.2) ENSMUST00000147196.1 ENSMUST00000147196.2 MRES1_MOUSE NM_026411 Q3TQU4 Q9CQF4 uc007ezk.1 uc007ezk.2 uc007ezk.3 Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability. Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue. Monomer. Interacts with POLRMT. Interacts (via S4 domain) with MTRFR (via C-terminus). Associates with mitoribosomal S39 large subunit, peptidyl tRNA and nascent chain. Mitochondrion matrix molecular_function RNA binding mitochondrion mitochondrial matrix biological_process regulation of transcription from mitochondrial promoter uc007ezk.1 uc007ezk.2 uc007ezk.3 
ENSMUST00000147206.3 Gm15634 ENSMUST00000147206.3 Gm15634 (from geneSymbol) ENSMUST00000147206.1 ENSMUST00000147206.2 uc291zri.1 uc291zri.2 uc291zri.3 uc291zri.1 uc291zri.2 uc291zri.3 
ENSMUST00000147231.3 Gm12409 ENSMUST00000147231.3 predicted gene 12409 (from RefSeq NR_046068.1) ENSMUST00000147231.1 ENSMUST00000147231.2 NR_046068 uc029uuc.1 uc029uuc.2 uc029uuc.3 uc029uuc.1 uc029uuc.2 uc029uuc.3 
ENSMUST00000147249.3 Gm28305 ENSMUST00000147249.3 Cell projection, cilium (from UniProt F6U473) AY259500 ENSMUST00000147249.1 ENSMUST00000147249.2 F6U473 F6U473_MOUSE Gm28305 uc292kii.1 uc292kii.2 Cell projection, cilium uc292kii.1 uc292kii.2 
ENSMUST00000147326.9 Milr1 ENSMUST00000147326.9 Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction. (from UniProt Q3TB92) AK137500 B2RTB7 B7ZP18 D6RUW9 ENSMUST00000147326.1 ENSMUST00000147326.2 ENSMUST00000147326.3 ENSMUST00000147326.4 ENSMUST00000147326.5 ENSMUST00000147326.6 ENSMUST00000147326.7 ENSMUST00000147326.8 Gm885 MILR1_MOUSE Mca32 Q3TB92 Q3TC23 Q3TDY5 Q3U5M7 Q3U9F5 uc288dam.1 uc288dam.2 Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction. Monomer (Probable). Interacts (tyrosine-phosphorylated) with PTPN6, PTPN11 and INPP5D. Cell membrane ; Single-pass type I membrane protein [Isoform 2]: Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TB92-1; Sequence=Displayed; Name=2; IsoId=Q3TB92-2; Sequence=VSP_028742; Expressed in myeloid cells (dendritic cells, macrophages and neutrophils but not in T-cells, B-cells or natural killer cells) and mast cells (at protein level). N-glycosylated. Enhanced IgE-mediated, mast cell-dependent passive systemic anaphylaxis. No effect on differentiation of hematopoietic cells, including mast cells. Sequence=BAE32051.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding extracellular region plasma membrane integral component of plasma membrane membrane integral component of membrane negative regulation of mast cell activation mast cell granule mast cell degranulation uc288dam.1 uc288dam.2 
ENSMUST00000147337.8 Mapkap1 ENSMUST00000147337.8 mitogen-activated protein kinase associated protein 1, transcript variant 1 (from RefSeq NM_177345.4) A2AN72 A2AN74 A2AR13 A2AR16 ENSMUST00000147337.1 ENSMUST00000147337.2 ENSMUST00000147337.3 ENSMUST00000147337.4 ENSMUST00000147337.5 ENSMUST00000147337.6 ENSMUST00000147337.7 Mip1 NM_177345 Q80UY4 Q8BKH7 Q8BMV5 Q8R2N9 SIN1_MOUSE Sin1 uc008jim.1 uc008jim.2 uc008jim.3 uc008jim.4 Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Isoform 1 is involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. All isoforms except isoform 4 can be incorporated into the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts with ATF2, MAP3K2 and MAPK8. Interacts with GTP-bound HRAS and KRAS. Interacts with IFNAR2 and SGK1. Isoform 2 interacts with NBN. Isoform 1 interacts with CCDC28B. Cell membrane ; Peripheral membrane protein Cytoplasmic vesicle Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BKH7-1; Sequence=Displayed; Name=2; IsoId=Q8BKH7-2; Sequence=VSP_033209; Name=3; IsoId=Q8BKH7-3; Sequence=VSP_033208; Uniquitously expressed, with highest levels in testis, kidney and liver. Present in renal tubule cells (at protein level). Death during early embryonic stages. Belongs to the SIN1 family. protein binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding nucleus nucleoplasm cytoplasm Golgi apparatus cytosol plasma membrane membrane Ras GTPase binding protein kinase binding establishment or maintenance of actin cytoskeleton polarity cytoplasmic vesicle TORC2 complex positive regulation of peptidyl-serine phosphorylation TORC2 signaling phosphatidylinositol-3,4-bisphosphate binding negative regulation of Ras protein signal transduction phosphatidic acid binding phosphatidylinositol-3,5-bisphosphate binding regulation of cellular response to oxidative stress uc008jim.1 uc008jim.2 uc008jim.3 uc008jim.4 
ENSMUST00000147357.3 Gm14642 ENSMUST00000147357.3 Gm14642 (from geneSymbol) ENSMUST00000147357.1 ENSMUST00000147357.2 uc290cyv.1 uc290cyv.2 uc290cyv.3 uc290cyv.1 uc290cyv.2 uc290cyv.3 
ENSMUST00000147378.2 Gm16291 ENSMUST00000147378.2 predicted gene 16291 (from RefSeq NR_045788.1) ENSMUST00000147378.1 NR_045788 uc029sor.1 uc029sor.2 uc029sor.1 uc029sor.2 
ENSMUST00000147398.9 Gm15350 ENSMUST00000147398.9 Gm15350 (from geneSymbol) AK018911 ENSMUST00000147398.1 ENSMUST00000147398.2 ENSMUST00000147398.3 ENSMUST00000147398.4 ENSMUST00000147398.5 ENSMUST00000147398.6 ENSMUST00000147398.7 ENSMUST00000147398.8 uc009kwi.1 uc009kwi.2 uc009kwi.3 uc009kwi.4 uc009kwi.1 uc009kwi.2 uc009kwi.3 uc009kwi.4 
ENSMUST00000147399.9 Cd101 ENSMUST00000147399.9 CD101 antigen (from RefSeq NM_001167906.2) A8E0Y8 A8E0Y9 ENSMUST00000147399.1 ENSMUST00000147399.2 ENSMUST00000147399.3 ENSMUST00000147399.4 ENSMUST00000147399.5 ENSMUST00000147399.6 ENSMUST00000147399.7 ENSMUST00000147399.8 IGSF2_MOUSE Igsf2 NM_001167906 uc012cuu.1 uc012cuu.2 uc012cuu.3 Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T- cell proliferation via IL10 secretion by cutaneous dendritic cells (By similarity). Membrane ; Single-pass type I membrane protein N-glycosylated. positive regulation of myeloid leukocyte differentiation molecular_function membrane integral component of membrane uc012cuu.1 uc012cuu.2 uc012cuu.3 
ENSMUST00000147410.4 Hoxb3os ENSMUST00000147410.4 Hoxb3os (from geneSymbol) ENSMUST00000147410.1 ENSMUST00000147410.2 ENSMUST00000147410.3 uc288brd.1 uc288brd.2 uc288brd.1 uc288brd.2 
ENSMUST00000147412.2 Gm12204 ENSMUST00000147412.2 Gm12204 (from geneSymbol) ENSMUST00000147412.1 KY467585 uc287yae.1 uc287yae.2 uc287yae.1 uc287yae.2 
ENSMUST00000147420.2 Chn1os3 ENSMUST00000147420.2 chimerin 1, opposite strand 3 (from RefSeq NR_040623.1) ENSMUST00000147420.1 NR_040623 uc029tyb.1 uc029tyb.2 uc029tyb.1 uc029tyb.2 
ENSMUST00000147429.2 Gm15008 ENSMUST00000147429.2 predicted gene 15008 (from RefSeq NR_045917.1) ENSMUST00000147429.1 NR_045917 uc029xji.1 uc029xji.2 uc029xji.1 uc029xji.2 
ENSMUST00000147438.2 Gm11551 ENSMUST00000147438.2 Gm11551 (from geneSymbol) ENSMUST00000147438.1 uc288clw.1 uc288clw.2 uc288clw.1 uc288clw.2 
ENSMUST00000147449.2 Gm15541 ENSMUST00000147449.2 Gm15541 (from geneSymbol) AK144575 ENSMUST00000147449.1 uc291nfy.1 uc291nfy.2 uc291nfy.1 uc291nfy.2 
ENSMUST00000147494.2 Gm10558 ENSMUST00000147494.2 Gm10558 (from geneSymbol) AK145171 ENSMUST00000147494.1 uc287iwk.1 uc287iwk.2 uc287iwk.1 uc287iwk.2 
ENSMUST00000147504.2 Gm9968 ENSMUST00000147504.2 predicted gene 9968, transcript variant 2 (from RefSeq NR_167988.1) ENSMUST00000147504.1 NR_167988 uc289esp.1 uc289esp.2 uc289esp.1 uc289esp.2 
ENSMUST00000147509.3 Gm15391 ENSMUST00000147509.3 Gm15391 (from geneSymbol) ENSMUST00000147509.1 ENSMUST00000147509.2 uc287kyb.1 uc287kyb.2 uc287kyb.3 uc287kyb.1 uc287kyb.2 uc287kyb.3 
ENSMUST00000147525.9 Trmt9b ENSMUST00000147525.9 tRNA methyltransferase 9B, transcript variant 3 (from RefSeq NM_176952.5) ENSMUST00000147525.1 ENSMUST00000147525.2 ENSMUST00000147525.3 ENSMUST00000147525.4 ENSMUST00000147525.5 ENSMUST00000147525.6 ENSMUST00000147525.7 ENSMUST00000147525.8 Kiaa1456 NM_176952 Q5DTX8 Q80WQ4 Q8CA94 Q8CAM3 TRM9B_MOUSE Trmt9l uc009llm.1 uc009llm.2 uc009llm.3 May modify wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80WQ4-1; Sequence=Displayed; Name=2; IsoId=Q80WQ4-2; Sequence=VSP_032795; Name=3; IsoId=Q80WQ4-3; Sequence=VSP_032796, VSP_032797; Belongs to the methyltransferase superfamily. Sequence=BAD90446.1; Type=Erroneous initiation; Evidence=; tRNA wobble uridine modification nucleus cytoplasm tRNA processing methyltransferase activity tRNA methyltransferase activity tRNA (uracil) methyltransferase activity transferase activity tRNA methylation methylation uc009llm.1 uc009llm.2 uc009llm.3 
ENSMUST00000147538.3 1700122E12Rik ENSMUST00000147538.3 1700122E12Rik (from geneSymbol) AK007237 ENSMUST00000147538.1 ENSMUST00000147538.2 uc009mnq.1 uc009mnq.2 uc009mnq.3 uc009mnq.4 uc009mnq.1 uc009mnq.2 uc009mnq.3 uc009mnq.4 
ENSMUST00000147542.2 Gm15612 ENSMUST00000147542.2 predicted gene 15612 (from RefSeq NR_045880.1) ENSMUST00000147542.1 NR_045880 uc029vxo.1 uc029vxo.2 uc029vxo.1 uc029vxo.2 
ENSMUST00000147545.8 Ccdc6 ENSMUST00000147545.8 coiled-coil domain containing 6 (from RefSeq NM_001111121.2) CCDC6_MOUSE D3YZP9 ENSMUST00000147545.1 ENSMUST00000147545.2 ENSMUST00000147545.3 ENSMUST00000147545.4 ENSMUST00000147545.5 ENSMUST00000147545.6 ENSMUST00000147545.7 NM_001111121 uc011xfv.1 uc011xfv.2 Cytoplasm Cytoplasm, cytoskeleton Note=May be a cytoskeletal protein. The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation. molecular_function cytoplasm cytosol cytoskeleton biological_process SH3 domain binding uc011xfv.1 uc011xfv.2 
ENSMUST00000147563.9 Zdhhc3 ENSMUST00000147563.9 zinc finger, DHHC domain containing 3, transcript variant 2 (from RefSeq NM_026917.6) ENSMUST00000147563.1 ENSMUST00000147563.2 ENSMUST00000147563.3 ENSMUST00000147563.4 ENSMUST00000147563.5 ENSMUST00000147563.6 ENSMUST00000147563.7 ENSMUST00000147563.8 Godz Gramp1 NM_026917 Q6EMK3 Q8R173 ZDHC3_MOUSE Zdhhc3 uc009sfq.1 uc009sfq.2 uc009sfq.3 Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:15229235, PubMed:15603741, PubMed:16129400, PubMed:19001095, PubMed:23793055, PubMed:25253725, PubMed:26487721). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable). Plays an important role in G protein- coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (PubMed:19001095). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (By similarity). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (By similarity). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation (PubMed:15229235, PubMed:17151279, PubMed:27875292). Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses (PubMed:27875292). Palmitoylates NCDN thereby regulating its association with endosome membranes (PubMed:23687301). Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor (PubMed:27613864). Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth (PubMed:27247265). Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes (PubMed:18596047). Also constitutively palmitoylates DLG4 (PubMed:15603741). May also palmitoylate SNAP25 (PubMed:25253725). Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (PubMed:16129400, PubMed:27875292). Could also palmitoylate the D(2) dopamine receptor DRD2 (By similarity). May also palmitoylate LAMTOR1, promoting its localization to lysosomal membranes (By similarity). May also function as a calcium transporter. Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Reaction=L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S- tetradecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59736, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:15433, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:143199; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59737; Evidence=; Reaction=L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S- octadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59740, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:15434, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:143200; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59741; Evidence=; Monomer (PubMed:23793055). Homooligomers (PubMed:17151279, PubMed:23793055). The monomeric form has a higher catalytic activity (PubMed:23793055). Forms heterooligomers with ZDHHC7 (PubMed:17151279). Interacts with TNFRSF10A (By similarity). Golgi apparatus membrane ulti-pass membrane protein Note=Localizes to the Golgi cis cisterna. Widely expressed, with highest levels in brain. In the brain, expressed only in neurons (at protein level). The DHHC domain is required for palmitoyltransferase activity. Phosphorylation by FGFR1 and SRC probably regulates the palmitoyltransferase activity. Autopalmitoylated. Homozygous knockout mice are viable, fertile and do not display overt phenotype (PubMed:27875292). Male show a modest reduction in body weight (PubMed:27875292). Zdhhc3 and Zdhhc7 double knockout mice show a perinatally lethal phenotype (PubMed:27875292). Belongs to the DHHC palmitoyltransferase family. Golgi membrane endoplasmic reticulum Golgi apparatus protein targeting protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity protein localization to photoreceptor outer segment uc009sfq.1 uc009sfq.2 uc009sfq.3 
ENSMUST00000147594.2 4930453O03Rik ENSMUST00000147594.2 4930453O03Rik (from geneSymbol) AK015456 ENSMUST00000147594.1 uc287kge.1 uc287kge.2 uc287kge.1 uc287kge.2 
ENSMUST00000147595.7 Hoxa13 ENSMUST00000147595.7 homeobox A13 (from RefSeq NM_008264.1) ENSMUST00000147595.1 ENSMUST00000147595.2 ENSMUST00000147595.3 ENSMUST00000147595.4 ENSMUST00000147595.5 ENSMUST00000147595.6 HXA13_MOUSE Hox-1.10 NM_008264 Q62424 uc291enc.1 uc291enc.2 Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds DNA as a homodimer. Interacts with MEIS1, MEIS2 and MEIS3. Q62424; Q60954-2: Meis1; NbExp=3; IntAct=EBI-925160, EBI-445723; Q62424; P97454: Smad5; NbExp=3; IntAct=EBI-925160, EBI-7066475; Nucleus. Note=Defects in Hoxa13 are the cause of hypodactyly (Hd), a condition characterized by profound deficiency of digital arch structures. Belongs to the Abd-B homeobox family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding vasculogenesis endothelial cell morphogenesis tissue homeostasis ventricular septum development DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated multicellular organism development anatomical structure morphogenesis animal organ morphogenesis regulation of BMP signaling pathway male genitalia development embryonic forelimb morphogenesis sequence-specific DNA binding transcription regulatory region DNA binding positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter inner ear development artery morphogenesis branching involved in prostate gland morphogenesis endothelial cell fate specification positive regulation of mesenchymal cell apoptotic process uc291enc.1 uc291enc.2 
ENSMUST00000147604.8 Aim2 ENSMUST00000147604.8 absent in melanoma 2 (from RefSeq NM_001013779.2) AIM2_MOUSE Aim2 ENSMUST00000147604.1 ENSMUST00000147604.2 ENSMUST00000147604.3 ENSMUST00000147604.4 ENSMUST00000147604.5 ENSMUST00000147604.6 ENSMUST00000147604.7 Gm1313 Ifi210 NM_001013779 Q91VJ1 uc011wws.1 uc011wws.2 uc011wws.3 uc011wws.4 Sensor component of the AIM2 inflammasome, which mediates inflammasome activation in response to the presence of double-stranded DNA (dsDNA) in the cytosol, leading to subsequent pyroptosis (PubMed:19158679, PubMed:19131592, PubMed:20351692, PubMed:19158675, PubMed:19158676, PubMed:20351693, PubMed:20417169, PubMed:20457908, PubMed:21902795, PubMed:32350463, PubMed:34006824, PubMed:23567559). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:19131592, PubMed:20351692, PubMed:19158675, PubMed:19158676, PubMed:20351693, PubMed:20417169, PubMed:20457908, PubMed:21902795, PubMed:23567559, PubMed:32350463). Acts as a recognition receptor (PRR): specifically recognizes and binds dsDNA in the cytosol, and mediates the formation of the inflammasome polymeric complex composed of AIM2, CASP1 and PYCARD/ASC (PubMed:19131592, PubMed:20351692, PubMed:19158675, PubMed:19158676, PubMed:20351693, PubMed:20417169, PubMed:20457908, PubMed:21902795, PubMed:23567559). Recruitment of pro-caspase-1 (proCASP1) to the AIM2 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion (PubMed:19158676). In some cells, CASP1 activation mediates cleavage and activation of GSDMD, triggering pyroptosis without promoting cytokine secretion (PubMed:27846608, PubMed:32350463). Detects cytosolic dsDNA of viral and bacterial origin in a non- sequence-specific manner (PubMed:19131592, PubMed:19158675, PubMed:20351692, PubMed:23567559). Involved in the DNA damage response caused by acute ionizing radiation by mediating pyroptosis of intestinal epithelial cells and bone marrow cells in response to double-strand DNA breaks (PubMed:27846608). Mechanistically, AIM2 senses DNA damage in the nucleus to mediate inflammasome assembly and inflammatory cell death (PubMed:27846608). Also acts as a regulator of neurodevelopment via its role in the DNA damage response: acts by promoting neural cell death in response to DNA damage in the developing brain, thereby purging genetically compromised cells of the central nervous system (PubMed:32350463). Pyroptosis mediated by the AIM2 inflammasome in response to DNA damage is dependent on GSDMD without involving IL1B and IL18 cytokine secretion (PubMed:27846608, PubMed:32350463). Also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (PubMed:34471287). Can also trigger PYCARD/ASC-dependent, caspase-1-independent cell death that involves caspase-8 (CASP8) (PubMed:22555457). Also acts as a tumor suppressor independently of its role in inflammatory response (PubMed:26095253). Able to suppress overt cell proliferation in enterocytes: restricts stem cell proliferation in the intestinal mucosa in an inflammasome-independent manner, contributing to a decrease in the likelihood of colorectal cancer development (PubMed:26095253, PubMed:26107252). AIM2 suppresses cell proliferation by inhibiting phosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (PubMed:26095253, PubMed:26107252). Inhibits AKT1 phosphorylation both by inhibiting the activity of PRKDC/DNA-PK kinase and promoting dephosphorylation by PP2A phosphatase (PubMed:26107252, PubMed:33505023). Also acts as a key regulator of regulatory T-cells (Treg) homeostasis by promoting their stability: acts by preventing AKT1 activation (PubMed:33505023). Its role in Treg homeostasis is important to restain autoimmune diseases (PubMed:33505023). Inactive in absence of double-stranded DNA (dsDNA) (By similarity). Homooligomerizes upon binding to dsDNA, dsDNA serving as an oligomerization platform (By similarity). AIM2 requires large dsDNA to generate a structural template that couples dsDNA ligand- binding and homooligomerization (By similarity). Homooligomerization is followed by recruitment of PYCARD/ASC to initiate speck formation (nucleation) (By similarity). AIM2 and PYCARD/ASC homooligomer filaments assemble bidirectionally and the recognition between AIM2 and PYCARD/ASC oligomers occurs in a head-to-tail manner (By similarity). Clustered PYCARD/ASC nucleates the formation of CASP1 filaments through the interaction of their respective CARD domains, acting as a platform for CASP1 polymerization and activation (By similarity). Active CASP1 then specifically processes protein precursors, such as gasdermin-D (GSDMD), IL1B and IL18, leading to the release of mature cytokines in the extracellular milieu or pyroptosis, depending on cell type (PubMed:27846608, PubMed:32350463). AIM2 can be activated in response to events that cause genomic DNA (HIV protease inhibitor nelfinavir) or mitochondrial DNA release in the cytoplasm (such as Perfluoroalkyl substance pollutants or cholesterol overload) (PubMed:27462105, PubMed:29033131, PubMed:34006824). Activation of the AIM2 inflammasome is inhibited by IFI202 (PubMed:19131592, PubMed:23850291). Activation of the AIM2 inflammasome is inhibited by TRIM11, which promotes autophagy-dependent degradation of AIM2 (By similarity). Self-associates; forms homooligomers in response to cytosolic double-stranded DNA (dsDNA) and the dsDNA seems to serve as oligomerization platform (By similarity). Component of AIM2 inflammasome, which consists of a signal sensor component (AIM2), an adapter (PYCARD/ASC), which recruits an effector pro-inflammatory caspase (CASP1) (By similarity). Interacts (via pyrin domain) with PYCARD/ASC (via pyrin domain); interaction is direct (By similarity). Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis) (PubMed:34471287). Interacts with EIF2AK2/PKR (By similarity). Interacts with MAPRE1 (By similarity). Interacts (via HIN-200 domain) with IFI202 (via HIN-200 domain 2); preventing activation of the AIM2 inflammasome (PubMed:19131592, PubMed:23850291). Interacts with RACK1; promoting association with PP2A phosphatase and dephosphorylation of AKT1 (PubMed:33505023). Interacts with TRIM11; promoting AIM2 recruitment to autophagosomes and autophagy-dependent degradation (By similarity). Q91VJ1; Q91VJ1: Aim2; NbExp=2; IntAct=EBI-6253384, EBI-6253384; Cytoplasm flammasome Nucleus Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles (PubMed:19158679). Activated inflammasomes can also aggregate in the nucleus in response to DNA damage: AIM2 is recruited to double-strand DNA breaks and mediates activation of the AIM2 inflammasome (PubMed:27846608). Expressed in developing neurons (PubMed:27561456). Highly expressed in regulatory T-cells (Treg) (PubMed:33505023). By TGF-beta. The pyrin domain mediates homotypic interaction with PYCARD/ASC. The HIN-200 domain mediates dsDNA binding via electrostatic interactions. Degraded via selective autophagy following interaction with TRIM11. Mice display defects in neuronal morphology and changes in behavior, characterized by lower locomotor activity, anxiety and reduced auditory fear memory (PubMed:27561456, PubMed:32350463). Mice are protected from pyroptosis of intestinal epithelial cells caused by acute ionizing and subsequent intestinal damage: in contrast to wild-type mice, crypts of Aim2-deficient mice maintain their integrity (PubMed:27846608). Mice develop more tumors in the colon in the azoxymethane and dextran sulfate sodium model of colorectal cancer (PubMed:26095253, PubMed:26107252). Belongs to the HIN-200 family. Sequence=AAH09664.1; Type=Erroneous initiation; Evidence=; activation of innate immune response positive regulation of defense response to virus by host immune system process DNA binding double-stranded DNA binding protein binding nucleus nucleoplasm cytoplasm mitochondrion cytosol apoptotic process inflammatory response negative regulation of NF-kappaB transcription factor activity positive regulation of protein oligomerization positive regulation of interleukin-1 beta production tumor necrosis factor-mediated signaling pathway cellular response to interferon-beta cellular response to drug identical protein binding innate immune response interleukin-1 beta secretion positive regulation of interleukin-1 beta secretion positive regulation of NF-kappaB transcription factor activity pyroptosis AIM2 inflammasome complex positive regulation of cysteine-type endopeptidase activity uc011wws.1 uc011wws.2 uc011wws.3 uc011wws.4 
ENSMUST00000147615.2 Khdc1b ENSMUST00000147615.2 KH domain containing 1B (from RefSeq NM_001113187.1) ENSMUST00000147615.1 KHD1B_MOUSE NM_001113187 P0C7A0 uc007alp.1 uc007alp.2 uc007alp.3 uc007alp.4 Belongs to the KHDC1 family. Sequence=AK139842; Type=Frameshift; Evidence=; RNA binding protein binding cytoplasm activation of cysteine-type endopeptidase activity involved in apoptotic process identical protein binding uc007alp.1 uc007alp.2 uc007alp.3 uc007alp.4 
ENSMUST00000147630.2 Zfp97 ENSMUST00000147630.2 zinc finger protein 97 (from RefSeq NM_011765.5) E9PVC4 E9PZP6 E9PZP6_MOUSE ENSMUST00000147630.1 NM_011765 Zfp960 Zfp97 uc012akz.1 uc012akz.2 uc012akz.3 molecular_function nucleic acid binding nucleus regulation of transcription, DNA-templated biological_process metal ion binding uc012akz.1 uc012akz.2 uc012akz.3 
ENSMUST00000147632.3 Psmg4 ENSMUST00000147632.3 proteasome (prosome, macropain) assembly chaperone 4, transcript variant 2 (from RefSeq NM_001101430.2) ENSMUST00000147632.1 ENSMUST00000147632.2 NM_001101430 P0C7N9 PSMG4_MOUSE Pac4 uc007qbe.1 uc007qbe.2 uc007qbe.3 uc007qbe.4 uc007qbe.5 Chaperone protein which promotes assembly of the 20S proteasome. Interacts with PSMG3. Associates with alpha subunits of the 20S proteasome. Belongs to the PSMG4 family. molecular_function cellular_component biological_process proteasome assembly uc007qbe.1 uc007qbe.2 uc007qbe.3 uc007qbe.4 uc007qbe.5 
ENSMUST00000147638.2 Gm15943 ENSMUST00000147638.2 Gm15943 (from geneSymbol) AK042526 ENSMUST00000147638.1 uc288yeg.1 uc288yeg.2 uc288yeg.1 uc288yeg.2 
ENSMUST00000147653.2 Gm15398 ENSMUST00000147653.2 Gm15398 (from geneSymbol) ENSMUST00000147653.1 uc287sck.1 uc287sck.2 uc287sck.1 uc287sck.2 
ENSMUST00000147663.8 Lrrtm4 ENSMUST00000147663.8 leucine rich repeat transmembrane neuronal 4, transcript variant 3 (from RefSeq NM_001134743.1) A0A0R4J1T4 A0A0R4J1T4_MOUSE ENSMUST00000147663.1 ENSMUST00000147663.2 ENSMUST00000147663.3 ENSMUST00000147663.4 ENSMUST00000147663.5 ENSMUST00000147663.6 ENSMUST00000147663.7 Lrrtm4 NM_001134743 uc009ckf.1 uc009ckf.2 uc009ckf.3 Cell membrane ; Single-pass type I membrane protein Postsynaptic cell membrane ; Single-pass type I membrane protein Belongs to the LRRTM family. membrane integral component of membrane synapse organization glutamatergic synapse integral component of postsynaptic density membrane uc009ckf.1 uc009ckf.2 uc009ckf.3 
ENSMUST00000147678.3 Gm14102 ENSMUST00000147678.3 Gm14102 (from geneSymbol) ENSMUST00000147678.1 ENSMUST00000147678.2 uc290atm.1 uc290atm.2 uc290atm.3 uc290atm.1 uc290atm.2 uc290atm.3 
ENSMUST00000147681.4 Mir223hg ENSMUST00000147681.4 Mir223hg (from geneSymbol) AK036748 ENSMUST00000147681.1 ENSMUST00000147681.2 ENSMUST00000147681.3 uc292pnt.1 uc292pnt.2 uc292pnt.3 uc292pnt.4 uc292pnt.1 uc292pnt.2 uc292pnt.3 uc292pnt.4 
ENSMUST00000147691.2 Gm12534 ENSMUST00000147691.2 Gm12534 (from geneSymbol) ENSMUST00000147691.1 uc290esc.1 uc290esc.2 uc290esc.1 uc290esc.2 
ENSMUST00000147695.9 Lonrf2 ENSMUST00000147695.9 LON peptidase N-terminal domain and ring finger 2 (from RefSeq NM_001029878.2) ENSMUST00000147695.1 ENSMUST00000147695.2 ENSMUST00000147695.3 ENSMUST00000147695.4 ENSMUST00000147695.5 ENSMUST00000147695.6 ENSMUST00000147695.7 ENSMUST00000147695.8 F6ZE64 F6ZE64_MOUSE Lonrf2 NM_001029878 uc287hng.1 uc287hng.2 uc287hng.3 uc287hng.1 uc287hng.2 uc287hng.3 
ENSMUST00000147717.2 Gm12126 ENSMUST00000147717.2 predicted gene 12126 (from RefSeq NR_188975.1) ENSMUST00000147717.1 NR_188975 uc287xkk.1 uc287xkk.2 uc287xkk.1 uc287xkk.2 
ENSMUST00000147722.2 Gm16211 ENSMUST00000147722.2 Gm16211 (from geneSymbol) ENSMUST00000147722.1 uc290rsr.1 uc290rsr.2 uc290rsr.1 uc290rsr.2 
ENSMUST00000147742.9 Gm4779 ENSMUST00000147742.9 predicted gene 4779, transcript variant 3 (from RefSeq NR_164367.1) A0A1B0GR91 A0A1B0GR91_MOUSE ENSMUST00000147742.1 ENSMUST00000147742.2 ENSMUST00000147742.3 ENSMUST00000147742.4 ENSMUST00000147742.5 ENSMUST00000147742.6 ENSMUST00000147742.7 ENSMUST00000147742.8 Gm4779 NR_164367 uc292ptl.1 uc292ptl.2 uc292ptl.1 uc292ptl.2 
ENSMUST00000147771.2 Gm12051 ENSMUST00000147771.2 Gm12051 (from geneSymbol) ENSMUST00000147771.1 uc287wxn.1 uc287wxn.2 uc287wxn.1 uc287wxn.2 
ENSMUST00000147774.2 Gm16275 ENSMUST00000147774.2 Gm16275 (from geneSymbol) ENSMUST00000147774.1 uc289huo.1 uc289huo.2 uc289huo.1 uc289huo.2 
ENSMUST00000147802.9 Rab36 ENSMUST00000147802.9 RAB36, member RAS oncogene family, transcript variant 2 (from RefSeq NM_001359271.1) ENSMUST00000147802.1 ENSMUST00000147802.2 ENSMUST00000147802.3 ENSMUST00000147802.4 ENSMUST00000147802.5 ENSMUST00000147802.6 ENSMUST00000147802.7 ENSMUST00000147802.8 NM_001359271 Q8CAM5 RAB36_MOUSE uc007fpy.1 uc007fpy.2 uc007fpy.3 Protein transport. Probably involved in vesicular traffic (By similarity). Golgi apparatus membrane; Lipid-anchor. Belongs to the small GTPase superfamily. Rab family. Golgi membrane nucleotide binding GTPase activity GTP binding Golgi apparatus intracellular protein transport protein transport membrane Rab protein signal transduction uc007fpy.1 uc007fpy.2 uc007fpy.3 
ENSMUST00000147835.4 Rasl2-9 ENSMUST00000147835.4 RAS-like, family 2, locus 9 (from RefSeq NM_009028.2) ENSMUST00000147835.1 ENSMUST00000147835.2 ENSMUST00000147835.3 NM_009028 Q4FZF4 Q61820 Q6P8M7 Q80YD4 Q9D9Y0 RANT_MOUSE uc009fac.1 uc009fac.2 uc009fac.3 GTP-binding protein involved in nucleocytoplasmic transport (By similarity). Required for the import of protein into the nucleus and also for RNA export (By similarity). Involved in chromatin condensation and control of cell cycle (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Nucleus Testis specific. Belongs to the small GTPase superfamily. Ran family. Sequence=AAH49619.1; Type=Erroneous initiation; Evidence=; nucleotide binding GTPase activity GTP binding nucleus cytoplasm protein import into nucleus nucleocytoplasmic transport protein transport uc009fac.1 uc009fac.2 uc009fac.3 
ENSMUST00000147847.2 Gm12227 ENSMUST00000147847.2 Gm12227 (from geneSymbol) BC067249 ENSMUST00000147847.1 uc007iyg.1 uc007iyg.2 uc007iyg.3 uc007iyg.1 uc007iyg.2 uc007iyg.3 
ENSMUST00000147848.2 4931406G06Rik ENSMUST00000147848.2 4931406G06Rik (from geneSymbol) AK016435 ENSMUST00000147848.1 uc289fzh.1 uc289fzh.2 uc289fzh.1 uc289fzh.2 
ENSMUST00000147854.6 Ugt2a1 ENSMUST00000147854.6 UDP glucuronosyltransferase 2 family, polypeptide A1 (from RefSeq NM_053184.2) ENSMUST00000147854.1 ENSMUST00000147854.2 ENSMUST00000147854.3 ENSMUST00000147854.4 ENSMUST00000147854.5 NM_053184 Q80X89 Q9ESE4 UD2A1_MOUSE Ugt2a1 uc008xyl.1 uc008xyl.2 uc008xyl.3 UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterones) and estrogens (estradiol and estriol). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction. Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21033; Evidence=; Reaction=16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52880, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:87620, ChEBI:CHEBI:136886; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52881; Evidence=; Reaction=16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52920, ChEBI:CHEBI:15378, ChEBI:CHEBI:42156, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136884; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52921; Evidence=; Reaction=17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52872, ChEBI:CHEBI:15378, ChEBI:CHEBI:17160, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136642; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52873; Evidence=; Reaction=17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52868, ChEBI:CHEBI:15378, ChEBI:CHEBI:17160, ChEBI:CHEBI:57529, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52869; Evidence=; Reaction=17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52460, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136641; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52461; Evidence=; Reaction=17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52464, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:82961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52465; Evidence=; Reaction=testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52456, ChEBI:CHEBI:15378, ChEBI:CHEBI:17347, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136639; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52457; Evidence=; Reaction=epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52568, ChEBI:CHEBI:15378, ChEBI:CHEBI:42534, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136673; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52569; Evidence=; Reaction=lithocholate + UDP-alpha-D-glucuronate = H(+) + lithocholoyl- 3-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:53028, ChEBI:CHEBI:15378, ChEBI:CHEBI:29744, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136965; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53029; Evidence=; Reaction=lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O- (beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52952, ChEBI:CHEBI:29744, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136902; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52953; Evidence=; Reaction=deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O- (beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52948, ChEBI:CHEBI:23614, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136901; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52949; Evidence=; Reaction=hyodeoxycholate + UDP-alpha-D-glucuronate = H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52964, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:58875, ChEBI:CHEBI:136905; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52965; Evidence=; Reaction=hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta- D-glucuronate) + UDP; Xref=Rhea:RHEA:52960, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:133661, ChEBI:CHEBI:136904; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52961; Evidence=; Membrane ; Single- pass type I membrane protein Belongs to the UDP-glycosyltransferase family. plasma membrane sensory perception of smell UDP-glycosyltransferase activity glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups intracellular membrane-bounded organelle response to stimulus cellular glucuronidation uc008xyl.1 uc008xyl.2 uc008xyl.3 
ENSMUST00000147868.3 Gm14097 ENSMUST00000147868.3 Gm14097 (from geneSymbol) ENSMUST00000147868.1 ENSMUST00000147868.2 uc290asx.1 uc290asx.2 uc290asx.3 uc290asx.1 uc290asx.2 uc290asx.3 
ENSMUST00000147875.9 Lyrm9 ENSMUST00000147875.9 LYR motif containing 9 (from RefSeq NM_001076681.2) A1L3P7 ENSMUST00000147875.1 ENSMUST00000147875.2 ENSMUST00000147875.3 ENSMUST00000147875.4 ENSMUST00000147875.5 ENSMUST00000147875.6 ENSMUST00000147875.7 ENSMUST00000147875.8 LYRM9_MOUSE NM_001076681 Q3UN90 uc007kkb.1 uc007kkb.2 uc007kkb.3 uc007kkb.4 Belongs to the complex I LYR family. LYRM9 subfamily. molecular_function cellular_component biological_process uc007kkb.1 uc007kkb.2 uc007kkb.3 uc007kkb.4 
ENSMUST00000147896.2 Gm12114 ENSMUST00000147896.2 Gm12114 (from geneSymbol) ENSMUST00000147896.1 uc287xik.1 uc287xik.2 uc287xik.1 uc287xik.2 
ENSMUST00000147973.3 ENSMUSG00000121654 ENSMUST00000147973.3 ENSMUSG00000121654 (from geneSymbol) AK048462 ENSMUST00000147973.1 ENSMUST00000147973.2 uc288pqv.1 uc288pqv.2 uc288pqv.1 uc288pqv.2 
ENSMUST00000147991.2 Paqr6 ENSMUST00000147991.2 progestin and adipoQ receptor family member VI, transcript variant 1 (from RefSeq NM_198410.3) ENSMUST00000147991.1 NM_198410 PAQR6_MOUSE Paqr6 Q3UTT0 Q6TCG5 Q8CF56 uc012crs.1 uc012crs.2 Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. Involved in neurosteroid inhibition of apoptosis. May be involved in regulating rapid P4 signaling in the nervous system. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone. Homodimer. Cell membrane ; Multi-pass membrane protein Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). Belongs to the ADIPOR family. steroid binding plasma membrane lipid binding membrane integral component of membrane signaling receptor activity uc012crs.1 uc012crs.2 
ENSMUST00000147993.8 Gm2117 ENSMUST00000147993.8 Gm2117 (from geneSymbol) AK139882 ENSMUST00000147993.1 ENSMUST00000147993.2 ENSMUST00000147993.3 ENSMUST00000147993.4 ENSMUST00000147993.5 ENSMUST00000147993.6 ENSMUST00000147993.7 uc009svv.1 uc009svv.2 uc009svv.1 uc009svv.2 
ENSMUST00000148011.8 Pms2 ENSMUST00000148011.8 PMS1 homolog2, mismatch repair system component (from RefSeq NM_008886.3) B9EJ22 ENSMUST00000148011.1 ENSMUST00000148011.2 ENSMUST00000148011.3 ENSMUST00000148011.4 ENSMUST00000148011.5 ENSMUST00000148011.6 ENSMUST00000148011.7 NM_008886 P54279 PMS2_MOUSE Pms2 uc009ala.1 uc009ala.2 uc009ala.3 Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Heterodimer of PMS2 and MLH1 (MutL alpha); this interaction is required for the stability of both partners. Forms a ternary complex with MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3). Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with MTMR15/FAN1. Nucleus Belongs to the DNA mismatch repair MutL/HexB family. Sequence=AAA87031.1; Type=Frameshift; Evidence=; DNA binding nuclease activity endonuclease activity ATP binding nucleus nucleoplasm cytosol plasma membrane DNA repair mismatch repair cellular response to DNA damage stimulus microtubule cytoskeleton somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments hydrolase activity ATPase activity mismatched DNA binding single base insertion or deletion binding mismatch repair complex MutLalpha complex cytoplasmic ribonucleoprotein granule positive regulation of isotype switching to IgA isotypes positive regulation of isotype switching to IgG isotypes meiotic cell cycle nucleic acid phosphodiester bond hydrolysis single-stranded DNA binding MutSalpha complex binding uc009ala.1 uc009ala.2 uc009ala.3 
ENSMUST00000148057.2 Gm15642 ENSMUST00000148057.2 Gm15642 (from geneSymbol) ENSMUST00000148057.1 uc288der.1 uc288der.2 uc288der.1 uc288der.2 
ENSMUST00000148063.8 A430035B10Rik ENSMUST00000148063.8 A430035B10Rik (from geneSymbol) AK039608 ENSMUST00000148063.1 ENSMUST00000148063.2 ENSMUST00000148063.3 ENSMUST00000148063.4 ENSMUST00000148063.5 ENSMUST00000148063.6 ENSMUST00000148063.7 uc009axp.1 uc009axp.2 uc009axp.1 uc009axp.2 
ENSMUST00000148064.2 Gm16278 ENSMUST00000148064.2 Gm16278 (from geneSymbol) AK043605 ENSMUST00000148064.1 uc289imv.1 uc289imv.2 uc289imv.1 uc289imv.2 
ENSMUST00000148082.2 Gm16599 ENSMUST00000148082.2 Gm16599 (from geneSymbol) AK016175 ENSMUST00000148082.1 uc033imv.1 uc033imv.2 uc033imv.1 uc033imv.2 
ENSMUST00000148086.8 Cep57 ENSMUST00000148086.8 centrosomal protein 57, transcript variant 2 (from RefSeq NR_037622.1) B8JJE6 CEP57_MOUSE ENSMUST00000148086.1 ENSMUST00000148086.2 ENSMUST00000148086.3 ENSMUST00000148086.4 ENSMUST00000148086.5 ENSMUST00000148086.6 ENSMUST00000148086.7 Kiaa0092 NR_037622 Q6ZQJ3 Q7TN18 Q80X65 Q810F2 Q8CEE0 Q9D4J4 Q9D5S4 Q9D5W5 Tsp57 uc292elu.1 uc292elu.2 Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2. Interacts with FGF2 and RAP80. Does not interact with FGF1 or FGF2 isoform 24 kDa (By similarity). Homodimer and homooligomer. Interacts with microtubules. Nucleus Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CEE0-1; Sequence=Displayed; Name=2; IsoId=Q8CEE0-2; Sequence=VSP_012266; Name=3; IsoId=Q8CEE0-3; Sequence=VSP_012265; Ubiquitous (at protein level). Expressed in testis, predominantly in round spermatids. Low expression is detected in other tissues. The C-terminal region mediates the interaction with microtubules and is able to nucleate and bundles microtubules in vitro. The centrosome localization domain (CLD) region mediates the localization to centrosomes and homooligomerization. Belongs to the translokin family. Sequence=AAH50785.1; Type=Erroneous initiation; Evidence=; Sequence=BAC97863.1; Type=Erroneous initiation; Evidence=; protein binding nucleus cytoplasm Golgi apparatus centrosome microtubule organizing center cytoskeleton microtubule spermatid development microtubule binding fibroblast growth factor receptor signaling pathway fibroblast growth factor binding microtubule anchoring identical protein binding protein homodimerization activity gamma-tubulin binding protein homooligomerization uc292elu.1 uc292elu.2 
ENSMUST00000148089.3 E030013I19Rik ENSMUST00000148089.3 E030013I19Rik (from geneSymbol) AK086944 ENSMUST00000148089.1 ENSMUST00000148089.2 uc289tck.1 uc289tck.2 uc289tck.1 uc289tck.2 
ENSMUST00000148136.3 Gm11665 ENSMUST00000148136.3 Gm11665 (from geneSymbol) AK139889 ENSMUST00000148136.1 ENSMUST00000148136.2 uc288cvv.1 uc288cvv.2 uc288cvv.3 uc288cvv.1 uc288cvv.2 uc288cvv.3 
ENSMUST00000148137.9 Lipo1 ENSMUST00000148137.9 lipase, member O1 (from RefSeq NM_001323065.1) ENSMUST00000148137.1 ENSMUST00000148137.2 ENSMUST00000148137.3 ENSMUST00000148137.4 ENSMUST00000148137.5 ENSMUST00000148137.6 ENSMUST00000148137.7 ENSMUST00000148137.8 F6WYC8 F6WYC8_MOUSE Lipo1 NM_001323065 uc057lat.1 uc057lat.2 uc057lat.3 Belongs to the AB hydrolase superfamily. Lipase family. sterol esterase activity lipid catabolic process sterol metabolic process hydrolase activity hydrolase activity, acting on ester bonds intracellular membrane-bounded organelle uc057lat.1 uc057lat.2 uc057lat.3 
ENSMUST00000148141.3 Gm45886 ENSMUST00000148141.3 Gm45886 (from geneSymbol) AK014119 ENSMUST00000148141.1 ENSMUST00000148141.2 uc292agj.1 uc292agj.2 uc292agj.1 uc292agj.2 
ENSMUST00000148178.8 Hnrnpm ENSMUST00000148178.8 heterogeneous nuclear ribonucleoprotein M, transcript variant 1 (from RefSeq NM_029804.3) ENSMUST00000148178.1 ENSMUST00000148178.2 ENSMUST00000148178.3 ENSMUST00000148178.4 ENSMUST00000148178.5 ENSMUST00000148178.6 ENSMUST00000148178.7 HNRPM_MOUSE Hnrpm NM_029804 Q6P1B2 Q99JQ0 Q9D0E1 uc008bze.1 uc008bze.2 uc008bze.3 uc008bze.4 Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines (By similarity). Identified in the spliceosome C complex (By similarity). Interacts with PPIA/CYPA (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D0E1-1; Sequence=Displayed; Name=2; IsoId=Q9D0E1-2; Sequence=VSP_011933; Sumoylated. alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding nucleus nucleoplasm spliceosomal complex cytoplasm mRNA processing RNA splicing cell surface nuclear matrix protein domain specific binding paraspeckles calcium-dependent protein binding catalytic step 2 spliceosome post-mRNA release spliceosomal complex positive regulation of protein localization to nucleus positive regulation of protein import protein antigen binding ribonucleoprotein complex regulation of mRNA stability involved in response to oxidative stress uc008bze.1 uc008bze.2 uc008bze.3 uc008bze.4 
ENSMUST00000148202.3 Gm14133 ENSMUST00000148202.3 Gm14133 (from geneSymbol) AK086556 ENSMUST00000148202.1 ENSMUST00000148202.2 uc290bet.1 uc290bet.2 uc290bet.3 uc290bet.1 uc290bet.2 uc290bet.3 
ENSMUST00000148217.2 Gm15156 ENSMUST00000148217.2 Gm15156 (from geneSymbol) ENSMUST00000148217.1 uc292rjy.1 uc292rjy.2 uc292rjy.1 uc292rjy.2 
ENSMUST00000148235.8 Cmc2 ENSMUST00000148235.8 C-X9-C motif containing 2 (from RefSeq NM_026844.3) COXM2_MOUSE ENSMUST00000148235.1 ENSMUST00000148235.2 ENSMUST00000148235.3 ENSMUST00000148235.4 ENSMUST00000148235.5 ENSMUST00000148235.6 ENSMUST00000148235.7 NM_026844 Q8CEV6 Q8K199 uc009nom.1 uc009nom.2 uc009nom.3 May be involved in cytochrome c oxidase biogenesis. Mitochondrion Belongs to the CMC family. molecular_function mitochondrion biological_process uc009nom.1 uc009nom.2 uc009nom.3 
ENSMUST00000148244.2 Gm12257 ENSMUST00000148244.2 Gm12257 (from geneSymbol) ENSMUST00000148244.1 uc287ylo.1 uc287ylo.2 uc287ylo.1 uc287ylo.2 
ENSMUST00000148290.2 Gm16253 ENSMUST00000148290.2 Gm16253 (from geneSymbol) AK052161 D3Z167 D3Z167_MOUSE ENSMUST00000148290.1 Gm16253 uc008qne.1 uc008qne.2 uc008qne.3 molecular_function cellular_component biological_process uc008qne.1 uc008qne.2 uc008qne.3 
ENSMUST00000148309.3 Gm14262 ENSMUST00000148309.3 Gm14262 (from geneSymbol) ENSMUST00000148309.1 ENSMUST00000148309.2 uc290cuu.1 uc290cuu.2 uc290cuu.3 uc290cuu.1 uc290cuu.2 uc290cuu.3 
ENSMUST00000148314.3 Gm13889 ENSMUST00000148314.3 predicted gene 13889 (from RefSeq NM_001145034.1) A0A087WSH6 A0A087WSH6_MOUSE ENSMUST00000148314.1 ENSMUST00000148314.2 Gm13889 NM_001145034 uc012bzx.1 uc012bzx.2 uc012bzx.3 uc012bzx.1 uc012bzx.2 uc012bzx.3 
ENSMUST00000148318.2 D030047H15Rik ENSMUST00000148318.2 RIKEN cDNA D030047H15 gene (from RefSeq NR_033548.1) ENSMUST00000148318.1 NR_033548 uc012ewr.1 uc012ewr.2 uc012ewr.1 uc012ewr.2 
ENSMUST00000148335.3 Gm15444 ENSMUST00000148335.3 Gm15444 (from geneSymbol) ENSMUST00000148335.1 ENSMUST00000148335.2 uc290htj.1 uc290htj.2 uc290htj.3 uc290htj.1 uc290htj.2 uc290htj.3 
ENSMUST00000148341.9 Loxhd1 ENSMUST00000148341.9 lipoxygenase homology domains 1, transcript variant 2 (from RefSeq NM_001414399.1) D3YUR7 D3YUR7_MOUSE ENSMUST00000148341.1 ENSMUST00000148341.2 ENSMUST00000148341.3 ENSMUST00000148341.4 ENSMUST00000148341.5 ENSMUST00000148341.6 ENSMUST00000148341.7 ENSMUST00000148341.8 Loxhd1 NM_001414399 uc289prw.1 uc289prw.2 uc289prw.3 Lacks conserved residue(s) required for the propagation of feature annotation. catalase activity heme binding oxidation-reduction process cellular oxidant detoxification uc289prw.1 uc289prw.2 uc289prw.3 
ENSMUST00000148364.2 Gm12056 ENSMUST00000148364.2 Gm12056 (from geneSymbol) ENSMUST00000148364.1 uc287wxq.1 uc287wxq.2 uc287wxq.1 uc287wxq.2 
ENSMUST00000148411.2 Slco1a7 ENSMUST00000148411.2 solute carrier organic anion transporter family, member 1a7 (from RefSeq NM_001378682.1) ENSMUST00000148411.1 Gm5724 L7N264 L7N264_MOUSE NM_001378682 Slco1a7 uc291jzq.1 uc291jzq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the organo anion transporter (TC 2.A.60) family. Lacks conserved residue(s) required for the propagation of feature annotation. plasma membrane integral component of plasma membrane ion transport bile acid transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity bile acid and bile salt transport membrane integral component of membrane sodium-independent organic anion transport transmembrane transport uc291jzq.1 uc291jzq.2 
ENSMUST00000148413.3 A530017D24Rik ENSMUST00000148413.3 A530017D24Rik (from geneSymbol) AK040705 ENSMUST00000148413.1 ENSMUST00000148413.2 uc287yus.1 uc287yus.2 uc287yus.1 uc287yus.2 
ENSMUST00000148420.2 Gm13966 ENSMUST00000148420.2 Gm13966 (from geneSymbol) ENSMUST00000148420.1 uc289zim.1 uc289zim.2 uc289zim.1 uc289zim.2 
ENSMUST00000148442.8 Zfp568 ENSMUST00000148442.8 zinc finger protein 568, transcript variant 1 (from RefSeq NM_001167872.1) E9PYI1 ENSMUST00000148442.1 ENSMUST00000148442.2 ENSMUST00000148442.3 ENSMUST00000148442.4 ENSMUST00000148442.5 ENSMUST00000148442.6 ENSMUST00000148442.7 NM_001167872 Q0VGV0 Q3UPK4 ZN568_MOUSE Zfp568 Znf568 chato uc009gct.1 uc009gct.2 uc009gct.3 uc009gct.4 Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction (PubMed:22110054, PubMed:27658112). Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536). Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155). May enhance proliferation or maintenance of neural stem cells (PubMed:23071813). Interacts with TRIM28. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9PYI1-1; Sequence=Displayed; Name=2; IsoId=E9PYI1-2; Sequence=VSP_058610; Little or no expression detected in most adult tissues (brain, liver, kidney, spleen, testis, ovary). In the hippocampus, detected in neural stem cells within the subventricular zone and subgranular zone. Expressed ubiquitously at 7.5 dpc and 8.5 dpc, with especially high levels in the extraembryonic ectoderm (PubMed:18701545). Expressed strongly in head from stages 10.5 dpc to 12.5 dpc (PubMed:23071813). In fetal brain, shows highest expression levels at stage 13.5 dpc with low levels thereafter (PubMed:23071813). Detected in neural stem cells of the neocortex at stage 12.5 dpc (PubMed:23071813). KRAB domain 1, but not KRAB domain 2, is required for transcriptional repression. Both contribute to interaction with TRIM28. Differences in repressive activity between KRAB domain 1 and 2 are likely due to amino acid differences at multiple residues. Mutant embryos arrest at 9 dpc, they fail to complete gastrulation, have convergent-extension failure and a yolk sac membrane-ruffling phenotype (PubMed:28522536). Conditional knockdown in neural stem cells results in reduced brain weight at birth, however adult brain weights are normal and no other defects in brain development or morphology are apparent (PubMed:23071813). Double knockout for ZNF568 and IGF2 embryos and fetuses are found at near Mendelian ratios and indistiguishable of wild type littermates at 12.5 dpc to 18.5 dpc. However, after birth few dead pups are recovered (PubMed:28522536). [Isoform 2]: May be due to competing acceptor splice site. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding transcription corepressor binding in utero embryonic development nucleic acid binding DNA binding protein binding nucleus regulation of transcription, DNA-templated multicellular organism development regulation of cell communication convergent extension involved in neural plate elongation negative regulation of transcription, DNA-templated metal ion binding convergent extension involved in axis elongation embryonic placenta morphogenesis uc009gct.1 uc009gct.2 uc009gct.3 uc009gct.4 
ENSMUST00000148448.2 Gm12532 ENSMUST00000148448.2 predicted gene 12532 (from RefSeq NR_153188.1) ENSMUST00000148448.1 NR_153188 uc290esa.1 uc290esa.2 uc290esa.1 uc290esa.2 
ENSMUST00000148464.2 Gm16191 ENSMUST00000148464.2 Gm16191 (from geneSymbol) ENSMUST00000148464.1 KY467778 uc289jcr.1 uc289jcr.2 uc289jcr.1 uc289jcr.2 
ENSMUST00000148466.3 A930024E05Rik ENSMUST00000148466.3 RIKEN cDNA A930024E05 gene (from RefSeq NR_045820.1) ENSMUST00000148466.1 ENSMUST00000148466.2 NR_045820 uc008zmw.1 uc008zmw.2 uc008zmw.3 uc008zmw.4 uc008zmw.5 uc008zmw.1 uc008zmw.2 uc008zmw.3 uc008zmw.4 uc008zmw.5 
ENSMUST00000148478.3 Gm15535 ENSMUST00000148478.3 Gm15535 (from geneSymbol) AK158189 ENSMUST00000148478.1 ENSMUST00000148478.2 uc008pqq.1 uc008pqq.2 uc008pqq.3 uc008pqq.1 uc008pqq.2 uc008pqq.3 
ENSMUST00000148484.9 Prcd ENSMUST00000148484.9 Involved in vision. (from UniProt Q00LT2) AK137302 ENSMUST00000148484.1 ENSMUST00000148484.2 ENSMUST00000148484.3 ENSMUST00000148484.4 ENSMUST00000148484.5 ENSMUST00000148484.6 ENSMUST00000148484.7 ENSMUST00000148484.8 Gm11744 PRCD_MOUSE Prcd Q00LT2 uc288dtx.1 uc288dtx.2 uc288dtx.3 Involved in vision. Interacts with RHO/rhodopsin; the interaction promotes PRCD stability. Cell projection, cilium, photoreceptor outer segment mbrane ipid-anchor ; Cytoplasmic side Endoplasmic reticulum Golgi apparatus Note=Localizes to photoreceptor disk membranes in the photoreceptor outer segment. Expressed in retina, where it localizes to both rod and cone photoreceptors (at protein level). Palmitoylated at Cys-2 (PubMed:27509380). Palmitoylation is essential for protein stability and trafficking to the photoreceptor outer segment, but does not appear to be essential for membrane localization (PubMed:27509380). Probably palmitoylated by ZDHHC3 (By similarity). Phosphorylated. Belongs to the PRCD family. photoreceptor outer segment opsin binding extracellular region cytoplasm endoplasmic reticulum Golgi apparatus visual perception membrane photoreceptor outer segment membrane cell projection response to stimulus uc288dtx.1 uc288dtx.2 uc288dtx.3 
ENSMUST00000148492.2 Gm11314 ENSMUST00000148492.2 Gm11314 (from geneSymbol) AK038391 ENSMUST00000148492.1 uc288lji.1 uc288lji.2 uc288lji.1 uc288lji.2 
ENSMUST00000148517.8 Mfap5 ENSMUST00000148517.8 microfibrillar associated protein 5, transcript variant 1 (from RefSeq NM_015776.3) ENSMUST00000148517.1 ENSMUST00000148517.2 ENSMUST00000148517.3 ENSMUST00000148517.4 ENSMUST00000148517.5 ENSMUST00000148517.6 ENSMUST00000148517.7 MFAP5_MOUSE Magp2 NM_015776 Q9QZJ6 uc009dpi.1 uc009dpi.2 uc009dpi.3 uc009dpi.4 May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (PubMed:23963447). Component of the elastin-associated microfibrils (By similarity). Interacts with TGFB2 (PubMed:23963447). Interacts with BMP2. Interacts with FBN1 (via N-terminal domain) and FBN2 (By similarity). Secreted, extracellular space, extracellular matrix Forms intermolecular disulfide bonds either with other MAGP-2 molecules or with other components of the microfibrils. Mice appear normal by several measures, are fertile, and have a normal life span, but are neutropenic. Belongs to the MFAP family. microfibril protein binding extracellular region extracellular space extracellular matrix constituent conferring elasticity extracellular matrix definitive hemopoiesis supramolecular fiber organization uc009dpi.1 uc009dpi.2 uc009dpi.3 uc009dpi.4 
ENSMUST00000148522.2 Gm14817 ENSMUST00000148522.2 Gm14817 (from geneSymbol) AK083681 ENSMUST00000148522.1 uc292osu.1 uc292osu.2 uc292osu.1 uc292osu.2 
ENSMUST00000148529.3 1700029M20Rik ENSMUST00000148529.3 1700029M20Rik (from geneSymbol) AK006510 ENSMUST00000148529.1 ENSMUST00000148529.2 uc290qwf.1 uc290qwf.2 uc290qwf.3 uc290qwf.1 uc290qwf.2 uc290qwf.3 
ENSMUST00000148532.4 Mamstr ENSMUST00000148532.4 MEF2 activating motif and SAP domain containing transcriptional regulator (from RefSeq NM_172418.2) A1L0X1 E9QM68 ENSMUST00000148532.1 ENSMUST00000148532.2 ENSMUST00000148532.3 MASTR_MOUSE Mastr NM_172418 Q0ZCJ7 Q3B818 uc009gwk.1 uc009gwk.2 uc009gwk.3 uc009gwk.4 Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation. Interacts with MEF2C. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0ZCJ7-1; Sequence=Displayed; Name=2; IsoId=Q0ZCJ7-2; Sequence=VSP_031556, VSP_031557; Expressed in skeletal muscle, brain, placenta and spleen. RNA polymerase II transcription factor binding protein binding nucleus positive regulation of myotube differentiation positive regulation of transcription from RNA polymerase II promoter uc009gwk.1 uc009gwk.2 uc009gwk.3 uc009gwk.4 
ENSMUST00000148542.8 Gm29247 ENSMUST00000148542.8 Gm29247 (from geneSymbol) AK006487 ENSMUST00000148542.1 ENSMUST00000148542.2 ENSMUST00000148542.3 ENSMUST00000148542.4 ENSMUST00000148542.5 ENSMUST00000148542.6 ENSMUST00000148542.7 uc287hts.1 uc287hts.2 uc287hts.1 uc287hts.2 
ENSMUST00000148568.2 Hopxos ENSMUST00000148568.2 Hopxos (from geneSymbol) AK087463 ENSMUST00000148568.1 uc290wph.1 uc290wph.2 uc290wph.1 uc290wph.2 
ENSMUST00000148587.8 Gm13986 ENSMUST00000148587.8 predicted gene 13986 (from RefSeq NR_126479.1) ENSMUST00000148587.1 ENSMUST00000148587.2 ENSMUST00000148587.3 ENSMUST00000148587.4 ENSMUST00000148587.5 ENSMUST00000148587.6 ENSMUST00000148587.7 NR_126479 uc008lrp.1 uc008lrp.2 uc008lrp.1 uc008lrp.2 
ENSMUST00000148597.2 Platr32 ENSMUST00000148597.2 Platr32 (from geneSymbol) ENSMUST00000148597.1 uc291ryk.1 uc291ryk.2 uc291ryk.1 uc291ryk.2 
ENSMUST00000148610.2 Gm10660 ENSMUST00000148610.2 Gm10660 (from geneSymbol) AK089991 ENSMUST00000148610.1 uc292ahy.1 uc292ahy.2 uc292ahy.1 uc292ahy.2 
ENSMUST00000148631.8 Fbxl12 ENSMUST00000148631.8 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity). (from UniProt Q9EPX5) AK031262 ENSMUST00000148631.1 ENSMUST00000148631.2 ENSMUST00000148631.3 ENSMUST00000148631.4 ENSMUST00000148631.5 ENSMUST00000148631.6 ENSMUST00000148631.7 FXL12_MOUSE Fbl12 Q3UVH7 Q8CDX0 Q9CY04 Q9EPX5 Q9QZN5 uc009oja.1 uc009oja.2 uc009oja.3 uc009oja.4 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity). Protein modification; protein ubiquitination. Interacts with SKP1 and CUL1. Sequence=AAF09134.1; Type=Frameshift; Evidence=; G2/M transition of mitotic cell cycle ubiquitin ligase complex nucleus cytoplasm cytosol ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process regulation of cell cycle ubiquitin protein ligase activity uc009oja.1 uc009oja.2 uc009oja.3 uc009oja.4 
ENSMUST00000148633.4 Sri ENSMUST00000148633.4 sorcin, transcript variant 1 (from RefSeq NM_001080974.2) ENSMUST00000148633.1 ENSMUST00000148633.2 ENSMUST00000148633.3 NM_001080974 Q3UKC5 Q6P069 Q9CR38 Q9D7V8 SORCN_MOUSE uc008wji.1 uc008wji.2 uc008wji.3 uc008wji.4 Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. Homodimer. Interacts with GCA, RYR2 and ANXA7 (By similarity). Cytoplasm Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P069-1; Sequence=Displayed; Name=2; IsoId=Q6P069-2; Sequence=VSP_013448; Detected in cardiac myocytes. This protein has been shown to bind calcium with high affinity. protease binding calcium ion binding protein binding nucleoplasm cytoplasm mitochondrion endoplasmic reticulum membrane smooth endoplasmic reticulum cytosol plasma membrane calcium ion transport heart development negative regulation of heart rate membrane sarcoplasmic reticulum Z disc T-tubule axon vesicle sarcoplasmic reticulum membrane positive regulation of insulin secretion involved in cellular response to glucose stimulus chromaffin granule membrane identical protein binding cytoplasmic sequestering of transcription factor axon terminus dendritic spine neck metal ion binding protein heterodimerization activity positive regulation of release of sequestered calcium ion into cytosol regulation of calcium ion transport negative regulation of cardiac muscle contraction negative regulation of ryanodine-sensitive calcium-release channel activity extracellular exosome repressing transcription factor binding regulation of cardiac muscle cell contraction regulation of relaxation of muscle regulation of high voltage-gated calcium channel activity regulation of cell communication by electrical coupling involved in cardiac conduction negative regulation of transcription regulatory region DNA binding uc008wji.1 uc008wji.2 uc008wji.3 uc008wji.4 
ENSMUST00000148635.2 Gm12914 ENSMUST00000148635.2 Gm12914 (from geneSymbol) ENSMUST00000148635.1 uc290nlh.1 uc290nlh.2 uc290nlh.1 uc290nlh.2 
ENSMUST00000148641.2 Gm15927 ENSMUST00000148641.2 Gm15927 (from geneSymbol) AK051804 ENSMUST00000148641.1 uc009evj.1 uc009evj.2 uc009evj.1 uc009evj.2 
ENSMUST00000148654.2 Gm15419 ENSMUST00000148654.2 Gm15419 (from geneSymbol) ENSMUST00000148654.1 uc291ydd.1 uc291ydd.2 uc291ydd.1 uc291ydd.2 
ENSMUST00000148655.3 Gm11959 ENSMUST00000148655.3 Gm11959 (from geneSymbol) AK019683 ENSMUST00000148655.1 ENSMUST00000148655.2 uc287whj.1 uc287whj.2 uc287whj.3 uc287whj.1 uc287whj.2 uc287whj.3 
ENSMUST00000148665.8 Sf3a2 ENSMUST00000148665.8 splicing factor 3a, subunit 2 (from RefSeq NM_013651.4) ENSMUST00000148665.1 ENSMUST00000148665.2 ENSMUST00000148665.3 ENSMUST00000148665.4 ENSMUST00000148665.5 ENSMUST00000148665.6 ENSMUST00000148665.7 G3UVU2 G3UVU2_MOUSE NM_013651 Sf3a2 uc011xiv.1 uc011xiv.2 uc011xiv.3 Belongs to the SF3A2 family. mRNA splicing, via spliceosome nucleic acid binding nucleus spliceosomal complex U2 snRNP mRNA processing zinc ion binding positive regulation of neuron projection development nuclear speck metal ion binding U2-type precatalytic spliceosome catalytic step 2 spliceosome U2-type prespliceosome assembly uc011xiv.1 uc011xiv.2 uc011xiv.3 
ENSMUST00000148687.2 Gm16638 ENSMUST00000148687.2 predicted gene, 16638, transcript variant 2 (from RefSeq NR_166697.1) ENSMUST00000148687.1 NR_166697 uc009idp.1 uc009idp.2 uc009idp.1 uc009idp.2 
ENSMUST00000148700.3 Gm14340 ENSMUST00000148700.3 Gm14340 (from geneSymbol) AK133152 ENSMUST00000148700.1 ENSMUST00000148700.2 uc290dkf.1 uc290dkf.2 uc290dkf.3 uc290dkf.1 uc290dkf.2 uc290dkf.3 
ENSMUST00000148721.8 2310061I04Rik ENSMUST00000148721.8 RIKEN cDNA 2310061I04 gene (from RefSeq NM_001033630.1) 2310061I04Rik B8JJ69 B8JJ69_MOUSE ENSMUST00000148721.1 ENSMUST00000148721.2 ENSMUST00000148721.3 ENSMUST00000148721.4 ENSMUST00000148721.5 ENSMUST00000148721.6 ENSMUST00000148721.7 NM_001033630 uc012arv.1 uc012arv.2 uc012arv.3 molecular_function mitochondrion biological_process uc012arv.1 uc012arv.2 uc012arv.3 
ENSMUST00000148734.3 Gm6471 ENSMUST00000148734.3 Gm6471 (from geneSymbol) AK139090 ENSMUST00000148734.1 ENSMUST00000148734.2 uc291xkr.1 uc291xkr.2 uc291xkr.1 uc291xkr.2 
ENSMUST00000148750.8 Slc4a4 ENSMUST00000148750.8 solute carrier family 4 (anion exchanger), member 4, transcript variant 1 (from RefSeq NM_018760.2) ENSMUST00000148750.1 ENSMUST00000148750.2 ENSMUST00000148750.3 ENSMUST00000148750.4 ENSMUST00000148750.5 ENSMUST00000148750.6 ENSMUST00000148750.7 NM_018760 Nbc1 Nbce1 O88343 Q3USE4 Q8BUG0 Q8QZR9 Q9R1C4 S4A4_MOUSE uc008yak.1 uc008yak.2 uc008yak.3 Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Reaction=2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in); Xref=Rhea:RHEA:72215, ChEBI:CHEBI:17544, ChEBI:CHEBI:29101; Evidence=; Reaction=3 hydrogencarbonate(out) + Na(+)(out) = 3 hydrogencarbonate(in) + Na(+)(in); Xref=Rhea:RHEA:72219, ChEBI:CHEBI:17544, ChEBI:CHEBI:29101; Evidence=; [Isoform 2]: Reaction=2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in); Xref=Rhea:RHEA:72215, ChEBI:CHEBI:17544, ChEBI:CHEBI:29101; Evidence=; [Isoform 2]: Reaction=3 hydrogencarbonate(out) + Na(+)(out) = 3 hydrogencarbonate(in) + Na(+)(in); Xref=Rhea:RHEA:72219, ChEBI:CHEBI:17544, ChEBI:CHEBI:29101; Evidence=; Activated by cyclic AMP. Homodimer (By similarity). Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity (PubMed:14567693, PubMed:15218065). Isoform 1 but not isoform 2 interacts with AHCYL1 (via PEST domain when phosphorylated); the interaction increases SLC4A4 isoform 1 activity (PubMed:16769890, PubMed:19033647, PubMed:21317537). Interacts with AHCYL2 (By similarity). O88343; Q64444: Ca4; NbExp=2; IntAct=EBI-771342, EBI-6859308; Basolateral cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=pNBC; IsoId=O88343-1; Sequence=Displayed; Name=2; Synonyms=kNBC; IsoId=O88343-2; Sequence=VSP_016709, VSP_016710; Name=3; IsoId=O88343-3; Sequence=VSP_016709, VSP_016710, VSP_016711, VSP_016712; Isoform 1 is specifically expressed in pancreatic ducts and acini (PubMed:19033647). Also expressed in parotid acinar cells and in the colonic crypts. Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase; phosphorylation seems to inhibit SLC4A4 activity (PubMed:21317537). N-glycosylated. May not be necessary for the transporter basic functions. Belongs to the anion exchanger (TC 2.A.31) family. inorganic anion exchanger activity protein binding plasma membrane integral component of plasma membrane ion transport sodium ion transport anion transport regulation of pH anion transmembrane transporter activity sodium:bicarbonate symporter activity symporter activity inorganic anion transport bicarbonate transport membrane integral component of membrane basolateral plasma membrane identical protein binding regulation of intracellular pH transmembrane transport anion transmembrane transport uc008yak.1 uc008yak.2 uc008yak.3 
ENSMUST00000148754.10 Acin1 ENSMUST00000148754.10 apoptotic chromatin condensation inducer 1, transcript variant 3 (from RefSeq NM_001085472.2) ACINU_MOUSE Acinus B8JJ87 ENSMUST00000148754.1 ENSMUST00000148754.2 ENSMUST00000148754.3 ENSMUST00000148754.4 ENSMUST00000148754.5 ENSMUST00000148754.6 ENSMUST00000148754.7 ENSMUST00000148754.8 ENSMUST00000148754.9 NM_001085472 Q9CSN7 Q9CSR9 Q9CSX7 Q9JIX8 Q9R046 Q9R047 uc011zld.1 uc011zld.2 uc011zld.3 Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells (By similarity). Found in a mRNA splicing-dependent exon junction complex (EJC). Component of the heterotrimeric ASAP (apoptosis- and splicing- associated protein) complexes consisting of RNPS1, SAP18 and different isoforms of ACIN1; the association of SAP18 seems to require a preformed RNPS1:ACIN1 complex. Interacts with API5. Interacts with SRPK2 in a phosphorylation-dependent manner (By similarity). Nucleus Nucleus speckle Nucleus, nucleoplasm Note=Phosphorylation on Ser-1179 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=L; IsoId=Q9JIX8-1; Sequence=Displayed; Name=2; Synonyms=S; IsoId=Q9JIX8-2; Sequence=VSP_004030, VSP_004033; Name=3; Synonyms=S'; IsoId=Q9JIX8-3; Sequence=VSP_004031; Name=4; IsoId=Q9JIX8-4; Sequence=VSP_004032; Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form. Phosphorylation on Ser-1179 by SRPK2 up-regulates its stimulatory effect on cyclin A1. Sequence=AAF89661.1; Type=Frameshift; Evidence=; nucleic acid binding nucleus nucleoplasm nucleolus cytosol plasma membrane mRNA processing apoptotic process RNA splicing nuclear speck erythrocyte differentiation apoptotic chromosome condensation positive regulation of apoptotic process positive regulation of monocyte differentiation negative regulation of mRNA splicing, via spliceosome ASAP complex exon-exon junction complex uc011zld.1 uc011zld.2 uc011zld.3 
ENSMUST00000148762.4 Zfp988 ENSMUST00000148762.4 zinc finger protein 988 (from RefSeq NM_001384232.1) ENSMUST00000148762.1 ENSMUST00000148762.2 ENSMUST00000148762.3 F6VKC7 F6VKC7_MOUSE NM_001384232 Zfp988 uc290rry.1 uc290rry.2 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290rry.1 uc290rry.2 
ENSMUST00000148776.4 Gm15506 ENSMUST00000148776.4 Gm15506 (from geneSymbol) AK052909 ENSMUST00000148776.1 ENSMUST00000148776.2 ENSMUST00000148776.3 uc009iks.1 uc009iks.2 uc009iks.3 uc009iks.4 uc009iks.1 uc009iks.2 uc009iks.3 uc009iks.4 
ENSMUST00000148810.8 Niban1 ENSMUST00000148810.8 niban apoptosis regulator 1, transcript variant 1 (from RefSeq NM_022018.4) A0PJB3 ENSMUST00000148810.1 ENSMUST00000148810.2 ENSMUST00000148810.3 ENSMUST00000148810.4 ENSMUST00000148810.5 ENSMUST00000148810.6 ENSMUST00000148810.7 Fam129a NIBA1_MOUSE NM_022018 Niban Niban1 Q3TD68 Q3UW53 Q6PE79 Q9ESL7 uc007cyz.1 uc007cyz.2 uc007cyz.3 uc007cyz.4 Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response. Cytoplasm Membrane ; Lipid-anchor By endoplasmic reticulum stress-inducing agents such as tunicamycin and thapsigargin in liver, kidney and cerebrum. No obvious phenotypic abnormalities but mice show increased phosphorylation of Eif2a and decreased phosphorylation of Eif4ebp1 and Rps6kb1. 'Niban' means 'second' in Japanese. Belongs to the Niban family. Sequence=AAH21332.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH58234.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI37844.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB17052.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC26641.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; negative regulation of protein phosphorylation positive regulation of protein phosphorylation molecular_function cytoplasm cytosol plasma membrane regulation of translation membrane response to endoplasmic reticulum stress positive regulation of translation uc007cyz.1 uc007cyz.2 uc007cyz.3 uc007cyz.4 
ENSMUST00000148843.10 Hnrnpr ENSMUST00000148843.10 heterogeneous nuclear ribonucleoprotein R, transcript variant 1 (from RefSeq NM_028871.2) ENSMUST00000148843.1 ENSMUST00000148843.2 ENSMUST00000148843.3 ENSMUST00000148843.4 ENSMUST00000148843.5 ENSMUST00000148843.6 ENSMUST00000148843.7 ENSMUST00000148843.8 ENSMUST00000148843.9 Hnrnpr Hnrpr NM_028871 Q8VHM5 Q8VHM5_MOUSE uc008vhy.1 uc008vhy.2 uc008vhy.3 uc008vhy.4 uc008vhy.5 Cytoplasm nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding nucleus nucleoplasm cytoplasm circadian rhythm dendrite growth cone negative regulation of catalytic activity axon terminus positive regulation of mRNA catabolic process mRNA destabilization catalytic step 2 spliceosome ribonucleoprotein complex uc008vhy.1 uc008vhy.2 uc008vhy.3 uc008vhy.4 uc008vhy.5 
ENSMUST00000148844.2 Gm12523 ENSMUST00000148844.2 Gm12523 (from geneSymbol) ENSMUST00000148844.1 uc290iry.1 uc290iry.2 uc290iry.1 uc290iry.2 
ENSMUST00000148850.8 Arhgap26 ENSMUST00000148850.8 Arhgap26 (from geneSymbol) BC141394 ENSMUST00000148850.1 ENSMUST00000148850.2 ENSMUST00000148850.3 ENSMUST00000148850.4 ENSMUST00000148850.5 ENSMUST00000148850.6 ENSMUST00000148850.7 uc289oxa.1 uc289oxa.2 uc289oxa.1 uc289oxa.2 
ENSMUST00000148862.2 ENSMUSG00000121322 ENSMUST00000148862.2 ENSMUSG00000121322 (from geneSymbol) ENSMUST00000148862.1 uc292rdj.1 uc292rdj.2 uc292rdj.1 uc292rdj.2 
ENSMUST00000148960.8 Myl12a ENSMUST00000148960.8 myosin, light chain 12A, regulatory, non-sarcomeric, transcript variant 1 (from RefSeq NM_026064.2) 2900073G15Rik ENSMUST00000148960.1 ENSMUST00000148960.2 ENSMUST00000148960.3 ENSMUST00000148960.4 ENSMUST00000148960.5 ENSMUST00000148960.6 ENSMUST00000148960.7 Gm49909 Myl12a Myl12b NM_026064 Q6ZWQ9 Q6ZWQ9_MOUSE uc008dlw.1 uc008dlw.2 uc008dlw.3 Q6ZWQ9; Q9NY61: AATF; Xeno; NbExp=3; IntAct=EBI-8034418, EBI-372428; stress fiber calcium ion binding protein binding regulation of cell shape myosin II complex Z disc macromolecular complex glutamate receptor binding protein localization to plasma membrane cell cortex region uc008dlw.1 uc008dlw.2 uc008dlw.3 
ENSMUST00000148989.3 Tnfaip8 ENSMUST00000148989.3 tumor necrosis factor, alpha-induced protein 8, transcript variant 2 (from RefSeq NM_001177759.1) D3YWJ5 D3YWJ5_MOUSE ENSMUST00000148989.1 ENSMUST00000148989.2 NM_001177759 Tnfaip8 uc012bcy.1 uc012bcy.2 uc012bcy.3 Cytoplasm Belongs to the TNFAIP8 family. regulation of apoptotic process uc012bcy.1 uc012bcy.2 uc012bcy.3 
ENSMUST00000149014.2 Gm13262 ENSMUST00000149014.2 predicted gene 13262 (from RefSeq NR_152218.1) ENSMUST00000149014.1 NR_152218 uc008ihj.1 uc008ihj.2 uc008ihj.3 uc008ihj.1 uc008ihj.2 uc008ihj.3 
ENSMUST00000149046.4 Rtl1 ENSMUST00000149046.4 retrotransposon Gaglike 1 (from RefSeq NM_184109.2) ENSMUST00000149046.1 ENSMUST00000149046.2 ENSMUST00000149046.3 Mar1 Mart1 NM_184109 Peg11 Q7M732 RTL1_MOUSE uc011ysk.1 uc011ysk.2 uc011ysk.3 Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta. Membrane ; Multi-pass membrane protein Expressed in placenta and in various tissues in late-fetal stage. Increased expression throughout development from 9.5 dpc to 18.5 dpc in placenta and, from 12.5 dpc to 15.5 dpc in embryo. Barely detectable in adult brain and midbrains of 14.5 dpc, but abundant at 8.5 dpc. Down-regulated during time-course of induced adipogenesis in 3T3L1 cells; Lipid accumulation is unchanged during adipocyte differentiation when Rtl1 is overexpressed. Mice suffer from late fetal or neonatal lethality. Mice overexpressing Rtl1 show notable overgrowth and morphological abnormalities of the placenta. Rtl1 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. Rtl1 is an imprinted gene located in a cluster of imprinted genes on distal chromosome 12. It is expressed from the paternal chromosome and has an antisense transcript expressed from the maternal chromosome containing 2 microRNAs, mir-136 and mir-127, with full complementarity to Rtl1; mir-136 and mir-127 are processed from an antisense transcript, Rtl1as, and may function as small interfering RNAs to silence Rtl1. molecular_function multicellular organism development membrane integral component of membrane uc011ysk.1 uc011ysk.2 uc011ysk.3 
ENSMUST00000149065.2 Gm16079 ENSMUST00000149065.2 Gm16079 (from geneSymbol) ENSMUST00000149065.1 uc290sba.1 uc290sba.2 uc290sba.1 uc290sba.2 
ENSMUST00000149128.3 Gm28039 ENSMUST00000149128.3 Gm28039 (from geneSymbol) ENSMUST00000149128.1 ENSMUST00000149128.2 KY468056 uc290xtu.1 uc290xtu.2 uc290xtu.1 uc290xtu.2 
ENSMUST00000149179.9 Col20a1 ENSMUST00000149179.9 Col20a1 (from geneSymbol) BC030415 Col20a1 ENSMUST00000149179.1 ENSMUST00000149179.2 ENSMUST00000149179.3 ENSMUST00000149179.4 ENSMUST00000149179.5 ENSMUST00000149179.6 ENSMUST00000149179.7 ENSMUST00000149179.8 F6UFI2 F6UFI2_MOUSE uc290dlb.1 uc290dlb.2 uc290dlb.1 uc290dlb.2 
ENSMUST00000149206.2 Gm14866 ENSMUST00000149206.2 predicted gene 14866 (from RefSeq NR_189040.1) ENSMUST00000149206.1 NR_189040 uc009twl.1 uc009twl.2 uc009twl.1 uc009twl.2 
ENSMUST00000149226.3 Gm11697 ENSMUST00000149226.3 Gm11697 (from geneSymbol) ENSMUST00000149226.1 ENSMUST00000149226.2 uc288dfj.1 uc288dfj.2 uc288dfj.3 uc288dfj.1 uc288dfj.2 uc288dfj.3 
ENSMUST00000149237.2 Gldnos ENSMUST00000149237.2 gliomedin, opposite strand (from RefSeq NR_045805.1) ENSMUST00000149237.1 NR_045805 uc029xbe.1 uc029xbe.2 uc029xbe.3 uc029xbe.1 uc029xbe.2 uc029xbe.3 
ENSMUST00000149239.2 4930412B13Rik ENSMUST00000149239.2 RIKEN cDNA 4930412B13 gene (from RefSeq NR_040631.1) ENSMUST00000149239.1 NR_040631 uc008lro.1 uc008lro.2 uc008lro.1 uc008lro.2 
ENSMUST00000149246.9 2410018L13Rik ENSMUST00000149246.9 2410018L13Rik (from geneSymbol) AK134640 ENSMUST00000149246.1 ENSMUST00000149246.2 ENSMUST00000149246.3 ENSMUST00000149246.4 ENSMUST00000149246.5 ENSMUST00000149246.6 ENSMUST00000149246.7 ENSMUST00000149246.8 uc011ykz.1 uc011ykz.2 uc011ykz.3 uc011ykz.4 uc011ykz.1 uc011ykz.2 uc011ykz.3 uc011ykz.4 
ENSMUST00000149247.3 Gm13075 ENSMUST00000149247.3 Gm13075 (from geneSymbol) BC047062 ENSMUST00000149247.1 ENSMUST00000149247.2 uc008vog.1 uc008vog.2 uc008vog.3 uc008vog.4 uc008vog.1 uc008vog.2 uc008vog.3 uc008vog.4 
ENSMUST00000149248.9 Spg7 ENSMUST00000149248.9 SPG7, paraplegin matrix AAA peptidase subunit, transcript variant 2 (from RefSeq NR_157166.1) B2RQY8 D3Z1Z1 ENSMUST00000149248.1 ENSMUST00000149248.2 ENSMUST00000149248.3 ENSMUST00000149248.4 ENSMUST00000149248.5 ENSMUST00000149248.6 ENSMUST00000149248.7 ENSMUST00000149248.8 NR_157166 Q3ULF4 Q4V9T9 Q7TNG0 Q80X42 Q811Y5 Q8K414 Q8R1A1 Q8R1K2 SPG7_MOUSE Spg7 uc009nud.1 uc009nud.2 uc009nud.3 ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Forms heterooligomers with AFG3L1 and AFG3L2 (PubMed:22563492, PubMed:17101804, PubMed:19656850). Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF (By similarity). Interacts with AFG3L2; the interaction is required for the efficient assembly of mitochondrial complex I (PubMed:22563492, PubMed:19656850). Interacts with AFG3L1 (PubMed:19656850). Interacts with MAIP1. Interacts with VDAC1 and PPIF (By similarity). Mitochondrion inner membrane ; Multi-pass membrane protein Expressed in the brain and retina (at protein level). Upon import into the mitochondrion, the N-terminal transit peptide is cleaved by the mitochondrial-processing peptidase (MPP) to generate an intermediate form which undergoes a second proteolytic cleavage mediated by proteases AFG3L1 and/or AFG3L2 removing an additional N- terminal fragment to generate the proteolytically active mature form. Mice are affected by a distal axonopathy of spinal and peripheral axons, characterized by axonal swelling and degeneration. Mitochondrial morphological abnormalities occur in synaptic terminals and in distal regions of axons long before the first signs of swelling and degeneration and correlate with onset of motor impairment during a rotarod test. In the N-terminal section; belongs to the AAA ATPase family. In the C-terminal section; belongs to the peptidase M41 family. According to PubMed:22563492, alternative splicing gives rise to an isoform (Paraplegin-2) which is identical to the sequence of the mature protein and localizes to the endoplasmic reticulum. Sequence=AAH55488.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH96690.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding metalloendopeptidase activity protein binding ATP binding mitochondrion mitochondrial inner membrane m-AAA complex mitochondrial permeability transition pore complex proteolysis mitochondrion organization cell adhesion anterograde axonal transport peptidase activity metallopeptidase activity zinc ion binding membrane integral component of membrane hydrolase activity regulation of cell adhesion metal ion binding regulation of mitochondrial membrane permeability mitochondrial outer membrane permeabilization involved in programmed cell death axon cytoplasm uc009nud.1 uc009nud.2 uc009nud.3 
ENSMUST00000149274.9 Taf1 ENSMUST00000149274.9 TATA-box binding protein associated factor 1, transcript variant 1 (from RefSeq NM_001290729.3) A0A067XG50 B1Q2W7 B1Q2W7_MOUSE ENSMUST00000149274.1 ENSMUST00000149274.2 ENSMUST00000149274.3 ENSMUST00000149274.4 ENSMUST00000149274.5 ENSMUST00000149274.6 ENSMUST00000149274.7 ENSMUST00000149274.8 N-TAF1 NM_001290729 Taf1 uc057mby.1 uc057mby.2 uc057mby.3 Nucleus Belongs to the TAF1 family. DNA binding protein serine/threonine kinase activity nucleus transcription factor TFIID complex DNA-templated transcription, initiation regulation of transcription, DNA-templated protein phosphorylation uc057mby.1 uc057mby.2 uc057mby.3 
ENSMUST00000149283.2 Gm13625 ENSMUST00000149283.2 Gm13625 (from geneSymbol) ENSMUST00000149283.1 uc289wsb.1 uc289wsb.2 uc289wsb.1 uc289wsb.2 
ENSMUST00000149285.2 Gm11455 ENSMUST00000149285.2 Gm11455 (from geneSymbol) ENSMUST00000149285.1 KY467913 uc290cjl.1 uc290cjl.2 uc290cjl.1 uc290cjl.2 
ENSMUST00000149300.8 Gm16534 ENSMUST00000149300.8 family with sequence similarity 78, member A, transcript variant 4 (from RefSeq NR_151495.1) ENSMUST00000149300.1 ENSMUST00000149300.2 ENSMUST00000149300.3 ENSMUST00000149300.4 ENSMUST00000149300.5 ENSMUST00000149300.6 ENSMUST00000149300.7 NR_151495 uc289uze.1 uc289uze.2 uc289uze.1 uc289uze.2 
ENSMUST00000149319.2 Tmem74bos ENSMUST00000149319.2 transmembrane 74B, opposite strand (from RefSeq NM_001378411.1) A0A571BEE7 A0A571BEE7_MOUSE ENSMUST00000149319.1 NM_001378411 Tmem74bos uc008neh.1 uc008neh.2 uc008neh.1 uc008neh.2 
ENSMUST00000149359.2 Mrtfb ENSMUST00000149359.2 myocardin related transcription factor B, transcript variant 1 (from RefSeq NM_153588.3) ENSMUST00000149359.1 Mkl2 Mrtfb NM_153588 Q5DTZ3 Q5DTZ3_MOUSE mKIAA1243 uc007yga.1 uc007yga.2 uc007yga.3 uc007yga.1 uc007yga.2 uc007yga.3 
ENSMUST00000149373.2 Rapgef3os1 ENSMUST00000149373.2 Rapgef3os1 (from geneSymbol) ENSMUST00000149373.1 uc289ayb.1 uc289ayb.2 uc289ayb.1 uc289ayb.2 
ENSMUST00000149377.2 Gm14618 ENSMUST00000149377.2 Gm14618 (from geneSymbol) ENSMUST00000149377.1 KY467929 uc057lfa.1 uc057lfa.2 uc057lfa.1 uc057lfa.2 
ENSMUST00000149378.2 Gm13398 ENSMUST00000149378.2 Gm13398 (from geneSymbol) A0A5F8MPV3 A0A5F8MPV3_MOUSE AK033844 ENSMUST00000149378.1 Gm13398 uc289uib.1 uc289uib.2 uc289uib.1 uc289uib.2 
ENSMUST00000149413.2 9530046B11Rik ENSMUST00000149413.2 9530046B11Rik (from geneSymbol) AK020596 ENSMUST00000149413.1 uc290yxn.1 uc290yxn.2 uc290yxn.1 uc290yxn.2 
ENSMUST00000149429.3 Gm13411 ENSMUST00000149429.3 Gm13411 (from geneSymbol) ENSMUST00000149429.1 ENSMUST00000149429.2 uc289tpq.1 uc289tpq.2 uc289tpq.3 uc289tpq.1 uc289tpq.2 uc289tpq.3 
ENSMUST00000149441.8 Mpnd ENSMUST00000149441.8 MPN domain containing (from RefSeq NM_026530.5) ENSMUST00000149441.1 ENSMUST00000149441.2 ENSMUST00000149441.3 ENSMUST00000149441.4 ENSMUST00000149441.5 ENSMUST00000149441.6 ENSMUST00000149441.7 MPND_MOUSE Mpnd NM_026530 Q3T9P5 Q3TV65 Q3UIC8 Q8VEN1 uc008dap.1 uc008dap.2 uc008dap.3 Probable protease (By similarity). Acts as a sensor of N(6)- methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (By similarity). The RAMA domain recognizes and binds N(6)-methyladenosine methylation on DNA (m6A). Degraded following binding to N(6)-methyladenosine methylated DNA (m6A). Belongs to the peptidase M67 family. Sequence=BAE27578.1; Type=Erroneous initiation; Evidence=; Sequence=BAE35755.1; Type=Frameshift; Evidence=; molecular_function proteolysis biological_process peptidase activity metallopeptidase activity SWI/SNF complex hydrolase activity metal ion binding uc008dap.1 uc008dap.2 uc008dap.3 
ENSMUST00000149452.2 Gm16279 ENSMUST00000149452.2 Gm16279 (from geneSymbol) AK034502 ENSMUST00000149452.1 uc008ciz.1 uc008ciz.2 uc008ciz.1 uc008ciz.2 
ENSMUST00000149481.2 Gm11986 ENSMUST00000149481.2 Gm11986 (from geneSymbol) AK043862 ENSMUST00000149481.1 uc287woz.1 uc287woz.2 uc287woz.1 uc287woz.2 
ENSMUST00000149488.3 B630019A10Rik ENSMUST00000149488.3 B630019A10Rik (from geneSymbol) AK046764 ENSMUST00000149488.1 ENSMUST00000149488.2 uc289dtw.1 uc289dtw.2 uc289dtw.3 uc289dtw.1 uc289dtw.2 uc289dtw.3 
ENSMUST00000149500.2 Gm14950 ENSMUST00000149500.2 Gm14950 (from geneSymbol) ENSMUST00000149500.1 uc292qir.1 uc292qir.2 uc292qir.1 uc292qir.2 
ENSMUST00000149523.2 Zfp133-ps ENSMUST00000149523.2 Zfp133-ps (from geneSymbol) AK137157 ENSMUST00000149523.1 uc290baa.1 uc290baa.2 uc290baa.1 uc290baa.2 
ENSMUST00000149552.3 Gm16758 ENSMUST00000149552.3 Gm16758 (from geneSymbol) BC066032 ENSMUST00000149552.1 ENSMUST00000149552.2 uc289jms.1 uc289jms.2 uc289jms.1 uc289jms.2 
ENSMUST00000149564.8 2700049A03Rik ENSMUST00000149564.8 RIKEN cDNA 2700049A03 gene, transcript variant 1 (from RefSeq NM_001163378.2) B2RWX3 E9PV87 ENSMUST00000149564.1 ENSMUST00000149564.2 ENSMUST00000149564.3 ENSMUST00000149564.4 ENSMUST00000149564.5 ENSMUST00000149564.6 ENSMUST00000149564.7 NM_001163378 TALD3_MOUSE Talpid3 uc007nun.1 uc007nun.2 uc007nun.3 Required for ciliogenesis and sonic hedgehog/SHH signaling (PubMed:21750036). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (By similarity). Involved in regulation of cell intracellular organization (PubMed:26386247). Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (PubMed:25251415). Interacts with CEP120 (PubMed:25251415). Interacts with CCP110, CEP290, CEP97, KIF24 (By similarity). E9PV87; Q7TSG1: Cep120; NbExp=3; IntAct=EBI-11692182, EBI-2553947; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Photoreceptor inner segment Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body Note=In photoreceptor cells localized to the joint between the inner and outer segments, specifically localized at the mother centriole (basal body) and the adjacent centriole as well as between the two centrioles but not in the connecting cilium (PubMed:26386247). Expressed in photoreceptor cells (at protein level). Deficient mice die during organogenesis, lack cilia, and have randomized left-right patterning, pericardial edema and hemorrhages. Belongs to the TALPID3 family. Sequence=AAI50745.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; photoreceptor inner segment protein binding cytoplasm centrosome centriole microtubule organizing center cytoskeleton smoothened signaling pathway cell projection organization ciliary basal body cell projection cilium assembly regulation of establishment of protein localization uc007nun.1 uc007nun.2 uc007nun.3 
ENSMUST00000149565.8 Agpat5 ENSMUST00000149565.8 1-acylglycerol-3-phosphate O-acyltransferase 5 (from RefSeq NM_026792.3) D8Ertd319e ENSMUST00000149565.1 ENSMUST00000149565.2 ENSMUST00000149565.3 ENSMUST00000149565.4 ENSMUST00000149565.5 ENSMUST00000149565.6 ENSMUST00000149565.7 NM_026792 PLCE_MOUSE Q3U702 Q8BG61 Q8CGN6 Q9D1E8 uc009kzv.1 uc009kzv.2 uc009kzv.3 Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:15367102). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (By similarity). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl- CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (By similarity). Activity toward lysophosphatidylglycerol not detectable (By similarity). Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19710; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37171, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:74544, ChEBI:CHEBI:74579; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37172; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37175, ChEBI:CHEBI:57287, ChEBI:CHEBI:74309, ChEBI:CHEBI:74544, ChEBI:CHEBI:74578; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37176; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37147, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:74544, ChEBI:CHEBI:74552; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37148; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37595, ChEBI:CHEBI:57287, ChEBI:CHEBI:74544, ChEBI:CHEBI:75104, ChEBI:CHEBI:75105; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37596; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + CoA; Xref=Rhea:RHEA:37499, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74971, ChEBI:CHEBI:74986; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37500; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37387, ChEBI:CHEBI:28610, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74669; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37388; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn- glycero-3-phospho-(1D-myo-inositol) = 1-(9Z-octadecenoyl)-2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA; Xref=Rhea:RHEA:42216, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:78762, ChEBI:CHEBI:78765; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42217; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phospho-L-serine = 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L- serine + CoA; Xref=Rhea:RHEA:37407, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74617, ChEBI:CHEBI:74905; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37408; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn- glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37379, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74617, ChEBI:CHEBI:74897; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37380; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:33187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57518, ChEBI:CHEBI:64839; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33188; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37151, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74554, ChEBI:CHEBI:74556; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37152; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn- glycero-3-phosphate = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)- octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37455, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74938, ChEBI:CHEBI:74941; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37456; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37163, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74560, ChEBI:CHEBI:74565; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37164; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn- glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37443, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74544, ChEBI:CHEBI:74928; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37444; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37155, ChEBI:CHEBI:57287, ChEBI:CHEBI:74307, ChEBI:CHEBI:74544, ChEBI:CHEBI:74558; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37156; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn- glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)- icosatetraenoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37395, ChEBI:CHEBI:28610, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74671; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37396; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74544, ChEBI:CHEBI:74546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37132; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:42592, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:64839, ChEBI:CHEBI:74544; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42593; Evidence=; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 2/3. Endoplasmic reticulum membrane ; Multi-pass membrane protein Nucleus envelope Mitochondrion Widely expressed. The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. It is uncertain whether Met-1 or Met-12 is the initiator. hematopoietic progenitor cell differentiation 1-acylglycerol-3-phosphate O-acyltransferase activity nucleus nuclear envelope mitochondrion endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process acylglycerol metabolic process phospholipid biosynthetic process membrane integral component of membrane CDP-diacylglycerol biosynthetic process transferase activity transferase activity, transferring acyl groups phosphatidylinositol acyl-chain remodeling uc009kzv.1 uc009kzv.2 uc009kzv.3 
ENSMUST00000149569.9 Apol6 ENSMUST00000149569.9 apolipoprotein L 6, transcript variant 1 (from RefSeq NM_028010.1) Apol6 B7ZC54 B7ZC54_MOUSE ENSMUST00000149569.1 ENSMUST00000149569.2 ENSMUST00000149569.3 ENSMUST00000149569.4 ENSMUST00000149569.5 ENSMUST00000149569.6 ENSMUST00000149569.7 ENSMUST00000149569.8 NM_028010 uc007wnb.1 uc007wnb.2 uc007wnb.3 uc007wnb.4 Belongs to the apolipoprotein L family. cellular_component extracellular region lipid transport biological_process lipid binding lipoprotein metabolic process uc007wnb.1 uc007wnb.2 uc007wnb.3 uc007wnb.4 
ENSMUST00000149572.8 Platr9 ENSMUST00000149572.8 Platr9 (from geneSymbol) AK135746 ENSMUST00000149572.1 ENSMUST00000149572.2 ENSMUST00000149572.3 ENSMUST00000149572.4 ENSMUST00000149572.5 ENSMUST00000149572.6 ENSMUST00000149572.7 uc290lsw.1 uc290lsw.2 uc290lsw.1 uc290lsw.2 
ENSMUST00000149574.2 Gm14964 ENSMUST00000149574.2 Gm14964 (from geneSymbol) AK045826 ENSMUST00000149574.1 uc289qoh.1 uc289qoh.2 uc289qoh.1 uc289qoh.2 
ENSMUST00000149576.2 Gm14233 ENSMUST00000149576.2 Gm14233 (from geneSymbol) ENSMUST00000149576.1 uc290aqi.1 uc290aqi.2 uc290aqi.1 uc290aqi.2 
ENSMUST00000149592.3 Gm12065 ENSMUST00000149592.3 Gm12065 (from geneSymbol) ENSMUST00000149592.1 ENSMUST00000149592.2 uc287xat.1 uc287xat.2 uc287xat.3 uc287xat.1 uc287xat.2 uc287xat.3 
ENSMUST00000149604.5 Syna ENSMUST00000149604.5 syncytin a (from RefSeq NM_001013751.2) ENSMUST00000149604.1 ENSMUST00000149604.2 ENSMUST00000149604.3 ENSMUST00000149604.4 NM_001013751 Q5G5D5 SYNA_MOUSE Syna uc008zwk.1 uc008zwk.2 uc008zwk.3 uc008zwk.4 Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of a mouse endogenous retrovirus provirus on chromosome 5 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## endogenous retrovirus :: PMID: 15644441 RefSeq Select criteria :: based on longest protein ##RefSeq-Attributes-END## This endogenous retroviral envelope protein has retained its original fusogenic properties (PubMed:15644441, PubMed:17762178, PubMed:18077339, PubMed:19564597, PubMed:27589388). Together with Synb, participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis (PubMed:19564597). Syna is essential for placental development and is specifically required for formation of syncytiotrophoblast layer I (SynT-I) (PubMed:19564597). Promotes muscle myoblast fusion (PubMed:27589388). Does not have immunosuppressive activity (PubMed:18077339). The mature protein consists of a trimer of SU-TM heterodimers (Probable). The SU-TM heterodimers are attached by a labile interchain disulfide bond (By similarity). [Transmembrane protein]: Cell membrane ; Single-pass membrane protein [Surface protein]: Cell membrane ; Peripheral membrane protein Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. Highly expressed in placenta where it localizes to syncytiotrophoblasts of the labyrinthine zona (PubMed:15644441). Specifically localizes to syncytiotrophoblast layer I (SynT-I) (PubMed:18448564). Also detected at very low levels in hippocampus, brain, testis and ovary (PubMed:15644441). Expressed in the placental labyrinth from stage 8.5 dpc onwards. Synthesized as an inactive precursor that is heavily N- glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion. Embryonic lethal with no survival beyond stage 14.5 dpc (PubMed:19564597). Embryos show retarded growth but otherwise have no significant morphological defects (PubMed:19564597). Placental development is abnormal with significantly reduced vascularization of extraembryonic tissues (PubMed:19564597). In the placental labyrinth, there is an expansion of trophoblast cells which reduces available space for fetal blood vessels (PubMed:19564597). Trophoblast cells fail to fuse and form syncytiotrophoblast layer I (SynT-I), however development of syncytiotrophoblast layer II (SynT-II) is not significantly affected (PubMed:19564597). Double knockouts of Syna and Synb are embryonic lethal at stage 9.5 dpc to 10.5 dpc, indicating a more severe phenotype than the Syna single knockout (PubMed:22032925). The mouse genome contains a high percentage of proviral- like elements, also called endogenous retroviruses (ERVs) that are the genomic traces of ancient infections of the germline by exogenous retroviruses. Although most of these elements are defective, some have conserved a functional envelope (env) gene, most probably diverted by the host for its benefit. Belongs to the gamma type-C retroviral envelope protein family. syncytium formation by plasma membrane fusion plasma membrane multicellular organism development membrane integral component of membrane labyrinthine layer development uc008zwk.1 uc008zwk.2 uc008zwk.3 uc008zwk.4 
ENSMUST00000149608.3 Gm13840 ENSMUST00000149608.3 Gm13840 (from geneSymbol) ENSMUST00000149608.1 ENSMUST00000149608.2 uc290yuo.1 uc290yuo.2 uc290yuo.3 uc290yuo.1 uc290yuo.2 uc290yuo.3 
ENSMUST00000149609.4 Gm13830 ENSMUST00000149609.4 predicted gene 13830 (from RefSeq NR_131932.1) ENSMUST00000149609.1 ENSMUST00000149609.2 ENSMUST00000149609.3 NR_131932 uc057bvf.1 uc057bvf.2 uc057bvf.3 uc057bvf.4 uc057bvf.5 uc057bvf.1 uc057bvf.2 uc057bvf.3 uc057bvf.4 uc057bvf.5 
ENSMUST00000149661.3 Gm15325 ENSMUST00000149661.3 Gm15325 (from geneSymbol) ENSMUST00000149661.1 ENSMUST00000149661.2 uc288pyg.1 uc288pyg.2 uc288pyg.3 uc288pyg.1 uc288pyg.2 uc288pyg.3 
ENSMUST00000149692.2 Gm44503 ENSMUST00000149692.2 Cell projection, neuron projection Cytoplasm Dynein axonemal particle Nucleus (from UniProt E9PYU5) BC043049 Dyx1c1Ccpg1 E9PYU5 E9PYU5_MOUSE ENSMUST00000149692.1 Gm44503 uc292isa.1 uc292isa.2 Cell projection, neuron projection Cytoplasm Dynein axonemal particle Nucleus cilium movement epithelial cilium movement extracellular region centrosome determination of left/right symmetry heart development estrogen receptor binding outer dynein arm assembly inner dynein arm assembly non-motile cilium uc292isa.1 uc292isa.2 
ENSMUST00000149702.2 Ift88os ENSMUST00000149702.2 Ift88os (from geneSymbol) AK009774 ENSMUST00000149702.1 uc288uvf.1 uc288uvf.2 uc288uvf.1 uc288uvf.2 
ENSMUST00000149741.2 Gm15979 ENSMUST00000149741.2 Gm15979 (from geneSymbol) ENSMUST00000149741.1 KY468023 uc057lkj.1 uc057lkj.2 uc057lkj.1 uc057lkj.2 
ENSMUST00000149782.8 Gm20422 ENSMUST00000149782.8 Gm20422 (from geneSymbol) AK043654 E9PUR3 E9PUR3_MOUSE ENSMUST00000149782.1 ENSMUST00000149782.2 ENSMUST00000149782.3 ENSMUST00000149782.4 ENSMUST00000149782.5 ENSMUST00000149782.6 ENSMUST00000149782.7 Gm20422 uc292akx.1 uc292akx.2 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc292akx.1 uc292akx.2 
ENSMUST00000149815.5 Far2os2 ENSMUST00000149815.5 Far2os2 (from geneSymbol) AK020953 ENSMUST00000149815.1 ENSMUST00000149815.2 ENSMUST00000149815.3 ENSMUST00000149815.4 uc291kip.1 uc291kip.2 uc291kip.3 uc291kip.1 uc291kip.2 uc291kip.3 
ENSMUST00000149820.2 Gm13748 ENSMUST00000149820.2 Gm13748 (from geneSymbol) ENSMUST00000149820.1 uc287itm.1 uc287itm.2 uc287itm.1 uc287itm.2 
ENSMUST00000149825.2 4930503B20Rik ENSMUST00000149825.2 4930503B20Rik (from geneSymbol) 4930503B20Rik AK007081 ENSMUST00000149825.1 G5E8V6 G5E8V6_MOUSE uc290kky.1 uc290kky.2 molecular_function mitochondrion biological_process uc290kky.1 uc290kky.2 
ENSMUST00000149839.3 AW495222 ENSMUST00000149839.3 expressed sequence AW495222 (from RefSeq NR_045086.2) ENSMUST00000149839.1 ENSMUST00000149839.2 NR_045086 uc007rlm.1 uc007rlm.2 uc007rlm.3 uc007rlm.4 uc007rlm.5 uc007rlm.1 uc007rlm.2 uc007rlm.3 uc007rlm.4 uc007rlm.5 
ENSMUST00000149865.2 Slc13a2os ENSMUST00000149865.2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2, opposite strand (from RefSeq NR_003282.2) ENSMUST00000149865.1 NR_003282 uc007kje.1 uc007kje.2 uc007kje.1 uc007kje.2 
ENSMUST00000149873.2 Gm15246 ENSMUST00000149873.2 Gm15246 (from geneSymbol) AK051847 ENSMUST00000149873.1 uc292rui.1 uc292rui.2 uc292rui.1 uc292rui.2 
ENSMUST00000149884.2 Snapin ENSMUST00000149884.2 SNAP-associated protein (from RefSeq NM_133854.3) Bloc1s7 ENSMUST00000149884.1 NM_133854 Q3U8V4 Q922V7 Q9Z266 SNAPN_MOUSE Snap25bp Snapap uc008qck.1 uc008qck.2 uc008qck.3 uc008qck.4 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE- mediated membrane fusion in non-neuronal cells (PubMed:16760431, PubMed:19546860, PubMed:21998198). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity). Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos (PubMed:21998198). Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (By similarity). Associates with the SNARE complex. Interacts with CSNK1D, SNAP23 and STX4A but not with STX1A, VAMP2 and SYT1 (PubMed:12877659, PubMed:17101137). Interacts with SNAP25; the interaction with SNAP25 is increased by its phosphorylation (PubMed:10195194, PubMed:11283605). Interacts with CNTRL, NANOS1, PUM2 and RGS7. Interacts with TOR1A; the interaction is direct and associates SNAPIN with the CSN complex (By similarity). Q9Z266; Q06486-2: Csnk1d; Xeno; NbExp=4; IntAct=EBI-6170320, EBI-7088890; Membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytosol Cytoplasm, perinuclear region Golgi apparatus membrane Lysosome membrane Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Note=Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z266-1; Sequence=Displayed; Name=2; IsoId=Q9Z266-2; Sequence=VSP_009165, VSP_009166; Strongly expressed in heart, brain, testis, kidney and liver; low expression in spleen, lung and skeletal muscle. In the testis, expressed in the seminiferous tubules. Phosphorylated by PKD, phosphorylation controls SNAPIN protein stability (By similarity). Phosphorylated by CSNK1D/CK1. Belongs to the SNAPIN family. Golgi membrane SNARE binding protein binding cytoplasm lysosome lysosomal membrane Golgi apparatus cytosol intracellular protein transport exocytosis lysosome organization lysosomal lumen acidification chemical synaptic transmission synaptic vesicle anterograde axonal transport retrograde axonal transport endosome to lysosome transport negative regulation of neuron projection development membrane synaptic vesicle exocytosis synaptic vesicle maturation calcium ion regulated exocytosis cell junction secretory granule synaptic vesicle membrane BLOC-1 complex neuron projection development cytoplasmic vesicle synaptic vesicle fusion to presynaptic active zone membrane lysosome localization cellular protein complex localization regulation of protein binding synapse perinuclear region of cytoplasm synaptic vesicle transport anterograde synaptic vesicle transport protein maturation terminal button organization autophagosome maturation BORC complex late endosome to lysosome transport axon cytoplasm regulation of synaptic vesicle exocytosis uc008qck.1 uc008qck.2 uc008qck.3 uc008qck.4 
ENSMUST00000149903.9 Ccdc180 ENSMUST00000149903.9 Ccdc180 (from geneSymbol) AK053981 Ccdc180 E230008N13Rik ENSMUST00000149903.1 ENSMUST00000149903.2 ENSMUST00000149903.3 ENSMUST00000149903.4 ENSMUST00000149903.5 ENSMUST00000149903.6 ENSMUST00000149903.7 ENSMUST00000149903.8 F6QNN0 F6QNN0_MOUSE uc290mna.1 uc290mna.2 molecular_function biological_process uc290mna.1 uc290mna.2 
ENSMUST00000149909.2 D630008O14Rik ENSMUST00000149909.2 D630008O14Rik (from geneSymbol) AK085305 ENSMUST00000149909.1 uc007cgx.1 uc007cgx.2 uc007cgx.3 uc007cgx.1 uc007cgx.2 uc007cgx.3 
ENSMUST00000149935.4 Gm16283 ENSMUST00000149935.4 predicted gene 16283 (from RefSeq NR_175825.1) ENSMUST00000149935.1 ENSMUST00000149935.2 ENSMUST00000149935.3 NR_175825 uc008ewm.1 uc008ewm.2 uc008ewm.3 uc008ewm.4 uc008ewm.1 uc008ewm.2 uc008ewm.3 uc008ewm.4 
ENSMUST00000149940.2 Mir22hg ENSMUST00000149940.2 Mir22 host gene (non-protein coding) (from RefSeq NR_030711.1) ENSMUST00000149940.1 NR_030711 uc007kdv.1 uc007kdv.2 uc007kdv.3 uc007kdv.1 uc007kdv.2 uc007kdv.3 
ENSMUST00000149942.2 Gm831 ENSMUST00000149942.2 Gm831 (from geneSymbol) AK145047 ENSMUST00000149942.1 uc290qib.1 uc290qib.2 uc290qib.1 uc290qib.2 
ENSMUST00000149952.3 Gm2415 ENSMUST00000149952.3 Gm2415 (from geneSymbol) AK159035 ENSMUST00000149952.1 ENSMUST00000149952.2 uc292mbg.1 uc292mbg.2 uc292mbg.3 uc292mbg.1 uc292mbg.2 uc292mbg.3 
ENSMUST00000149958.3 4930448D08Rik ENSMUST00000149958.3 4930448D08Rik (from geneSymbol) AK015414 ENSMUST00000149958.1 ENSMUST00000149958.2 uc289poo.1 uc289poo.2 uc289poo.3 uc289poo.1 uc289poo.2 uc289poo.3 
ENSMUST00000149965.2 A430048G15Rik ENSMUST00000149965.2 A430048G15Rik (from geneSymbol) AK040035 ENSMUST00000149965.1 uc008mnq.1 uc008mnq.2 uc008mnq.1 uc008mnq.2 
ENSMUST00000149967.9 Rab3il1 ENSMUST00000149967.9 RAB3A interacting protein (rabin3)-like 1, transcript variant 8 (from RefSeq NM_001378860.1) D3YZ86 D3YZ86_MOUSE ENSMUST00000149967.1 ENSMUST00000149967.2 ENSMUST00000149967.3 ENSMUST00000149967.4 ENSMUST00000149967.5 ENSMUST00000149967.6 ENSMUST00000149967.7 ENSMUST00000149967.8 NM_001378860 Rab3il1 uc289qvo.1 uc289qvo.2 uc289qvo.3 Belongs to the SEC2 family. guanyl-nucleotide exchange factor activity uc289qvo.1 uc289qvo.2 uc289qvo.3 
ENSMUST00000149978.2 Inafm2 ENSMUST00000149978.2 InaF motif containing 2 (from RefSeq NM_001301269.1) A0A1L1STD6 A0A1L1STD6_MOUSE ENSMUST00000149978.1 Inafm2 NM_001301269 uc012cbk.1 uc012cbk.2 uc012cbk.3 calcium channel regulator activity membrane integral component of membrane uc012cbk.1 uc012cbk.2 uc012cbk.3 
ENSMUST00000149990.2 Gm16349 ENSMUST00000149990.2 Gm16349 (from geneSymbol) ENSMUST00000149990.1 uc292ddp.1 uc292ddp.2 uc292ddp.1 uc292ddp.2 
ENSMUST00000149994.2 Gm2309 ENSMUST00000149994.2 predicted gene 2309 (from RefSeq NR_165502.1) ENSMUST00000149994.1 NR_165502 uc009sxd.1 uc009sxd.2 uc009sxd.1 uc009sxd.2 
ENSMUST00000150006.9 Cdca2 ENSMUST00000150006.9 cell division cycle associated 2, transcript variant 2 (from RefSeq NM_175384.4) CDCA2_MOUSE ENSMUST00000150006.1 ENSMUST00000150006.2 ENSMUST00000150006.3 ENSMUST00000150006.4 ENSMUST00000150006.5 ENSMUST00000150006.6 ENSMUST00000150006.7 ENSMUST00000150006.8 NM_175384 Q14B71 Q8BSQ1 Q8CD75 uc007ulb.1 uc007ulb.2 uc007ulb.3 uc007ulb.4 Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity). Interacts with PPP1CC. Nucleus Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14B71-1; Sequence=Displayed; Name=2; IsoId=Q14B71-2; Sequence=VSP_025600, VSP_025601; Phosphorylated by CDK1. May regulate its subcellular location (By similarity). Sequence=AAI16299.1; Type=Erroneous initiation; Evidence=; Sequence=AAI16300.1; Type=Erroneous initiation; Evidence=; Sequence=BAC27343.1; Type=Erroneous initiation; Evidence=; molecular_function nucleus nucleoplasm chromosome cytosol cell cycle chromosome segregation positive regulation of protein dephosphorylation cell division uc007ulb.1 uc007ulb.2 uc007ulb.3 uc007ulb.4 
ENSMUST00000150023.2 Ston1 ENSMUST00000150023.2 May be involved in the endocytic machinery. (from UniProt Q8CDJ8) AK029878 ENSMUST00000150023.1 Q8CDJ8 Q8CDL8 Q9D5T3 STON1_MOUSE Salf Sblf Stn1 uc289nkx.1 uc289nkx.2 May be involved in the endocytic machinery. Cytoplasm Membrane Note=Some fraction is membrane-associated. In contrast to other members of the family, it does not contain NPF (Asn-Pro-Phe) sites and thereby does not interact with EPS15, EPS15R and ITSN1. Belongs to the Stoned B family. molecular_function cytoplasm endocytosis membrane regulation of endocytosis uc289nkx.1 uc289nkx.2 
ENSMUST00000150024.2 Dbhos ENSMUST00000150024.2 dopamine beta hydroxylase, opposite strand (from RefSeq NR_040524.1) ENSMUST00000150024.1 NR_040524 uc029twh.1 uc029twh.2 uc029twh.1 uc029twh.2 
ENSMUST00000150038.2 Gm10143 ENSMUST00000150038.2 Gm10143 (from geneSymbol) AK029975 ENSMUST00000150038.1 uc289qvr.1 uc289qvr.2 uc289qvr.1 uc289qvr.2 
ENSMUST00000150042.8 Mrpl48 ENSMUST00000150042.8 mitochondrial ribosomal protein L48, transcript variant 7 (from RefSeq NR_153428.1) E9QPQ8 E9QPQ8_MOUSE ENSMUST00000150042.1 ENSMUST00000150042.2 ENSMUST00000150042.3 ENSMUST00000150042.4 ENSMUST00000150042.5 ENSMUST00000150042.6 ENSMUST00000150042.7 Mrpl48 NR_153428 uc009ing.1 uc009ing.2 uc009ing.3 mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit uc009ing.1 uc009ing.2 uc009ing.3 
ENSMUST00000150068.2 Gm20518 ENSMUST00000150068.2 Lacks conserved residue(s) required for the propagation of feature annotation. (from UniProt E9Q548) AK037000 Dgcr2 E9Q548 E9Q548_MOUSE ENSMUST00000150068.1 Gm20518 uc289daf.1 uc289daf.2 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc289daf.1 uc289daf.2 
ENSMUST00000150111.4 Gm12493 ENSMUST00000150111.4 Gm12493 (from geneSymbol) AK157909 ENSMUST00000150111.1 ENSMUST00000150111.2 ENSMUST00000150111.3 uc290mks.1 uc290mks.2 uc290mks.3 uc290mks.4 uc290mks.1 uc290mks.2 uc290mks.3 uc290mks.4 
ENSMUST00000150119.2 Gm13632 ENSMUST00000150119.2 Gm13632 (from geneSymbol) ENSMUST00000150119.1 uc289wtm.1 uc289wtm.2 uc289wtm.1 uc289wtm.2 
ENSMUST00000150147.8 Vmn2r-ps54 ENSMUST00000150147.8 vomeronasal 2, receptor, pseudogene 54 (from RefSeq NR_004441.2) ENSMUST00000150147.1 ENSMUST00000150147.2 ENSMUST00000150147.3 ENSMUST00000150147.4 ENSMUST00000150147.5 ENSMUST00000150147.6 ENSMUST00000150147.7 NR_004441 uc012fis.1 uc012fis.2 uc012fis.1 uc012fis.2 
ENSMUST00000150159.2 Gm13802 ENSMUST00000150159.2 Gm13802 (from geneSymbol) ENSMUST00000150159.1 uc289yot.1 uc289yot.2 uc289yot.1 uc289yot.2 
ENSMUST00000150171.3 Gm12976 ENSMUST00000150171.3 Gm12976 (from geneSymbol) ENSMUST00000150171.1 ENSMUST00000150171.2 KY468019 uc008uwp.1 uc008uwp.2 uc008uwp.3 uc008uwp.4 uc008uwp.5 uc008uwp.1 uc008uwp.2 uc008uwp.3 uc008uwp.4 uc008uwp.5 
ENSMUST00000150178.3 ENSMUSG00000121437 ENSMUST00000150178.3 ENSMUSG00000121437 (from geneSymbol) ENSMUST00000150178.1 ENSMUST00000150178.2 uc289xxr.1 uc289xxr.2 uc289xxr.1 uc289xxr.2 
ENSMUST00000150195.2 C230066G23Rik ENSMUST00000150195.2 C230066G23Rik (from geneSymbol) ENSMUST00000150195.1 KY468052 uc290xsp.1 uc290xsp.2 uc290xsp.1 uc290xsp.2 
ENSMUST00000150203.2 Gm11210 ENSMUST00000150203.2 Gm11210 (from geneSymbol) ENSMUST00000150203.1 uc290ndr.1 uc290ndr.2 uc290ndr.1 uc290ndr.2 
ENSMUST00000150216.3 Gm12951 ENSMUST00000150216.3 Gm12951 (from geneSymbol) ENSMUST00000150216.1 ENSMUST00000150216.2 KY468012 uc057ljw.1 uc057ljw.2 uc057ljw.3 uc057ljw.1 uc057ljw.2 uc057ljw.3 
ENSMUST00000150235.8 Crem ENSMUST00000150235.8 cAMP responsive element modulator, transcript variant 1 (from RefSeq NM_001110859.2) CREM_MOUSE ENSMUST00000150235.1 ENSMUST00000150235.2 ENSMUST00000150235.3 ENSMUST00000150235.4 ENSMUST00000150235.5 ENSMUST00000150235.6 ENSMUST00000150235.7 NM_001110859 P27698 P27699 Q5XTP8 Q5XTP9 Q5XTQ0 Q5XTQ1 Q5XTQ2 Q5XTQ3 Q99JF1 uc033hfn.1 uc033hfn.2 uc033hfn.3 This gene encodes a basic-leucine zipper domain-containing protein that localizes to gene promoters, where it binds to the cyclic AMP response element (CRE). Different protein isoforms encoded by this gene may function as either activators or repressors of transcription. Activity of this gene is important in multiple developmental processes, including spermatogenesis. Mutation of this gene causes male infertility. Alternative splicing and promoter usage result in multiple transcript variants for this gene. [provided by RefSeq, Oct 2012]. Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform 2, isoform 3 and isoform 4 are repressors, while isoform 1 is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform 1 (activator) to CRE is increased by CREB3L4. The CREM isoform 1-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange (PubMed:16595651). [Isoform 11]: Plays a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. Binds DNA as a dimer (By similarity). Interacts with CDC34 (By similarity). Interacts with FHL5 (PubMed:10086359). May interact with TSSK4 (PubMed:26940607). Isoform 1 forms a heterodimer with CREB3L4 (PubMed:16595651). P27699; O09106: Hdac1; NbExp=3; IntAct=EBI-8744406, EBI-301912; Nucleus [Isoform 11]: Cytoplasm. Nucleus. Event=Alternative promoter usage, Alternative splicing; Named isoforms=11; Name=1; Synonyms=CREM-BCEFGgammaHIbeta, Tau; IsoId=P27699-1; Sequence=Displayed; Name=2; Synonyms=Alpha; IsoId=P27699-2; Sequence=VSP_000602, VSP_000603, VSP_000604, VSP_000607; Name=3; Synonyms=Beta; IsoId=P27699-3; Sequence=VSP_000602, VSP_000603, VSP_000604; Name=4; Synonyms=Gamma; IsoId=P27699-4; Sequence=VSP_000602, VSP_000605, VSP_000606; Name=5; Synonyms=Tau Alpha Gamma; IsoId=P27699-5; Sequence=VSP_038016, VSP_000607; Name=6; Synonyms=Tau 2 Alpha; IsoId=P27699-6; Sequence=VSP_000602, VSP_000607; Name=7; Synonyms=Tau 1 Alpha; IsoId=P27699-7; Sequence=VSP_000603, VSP_000604, VSP_000607; Name=8; Synonyms=Tau 1 Alpha Gamma; IsoId=P27699-8; Sequence=VSP_000605, VSP_000606, VSP_000607; Name=9; Synonyms=Tau 1 Gamma; IsoId=P27699-9; Sequence=VSP_000605, VSP_000606; Name=10; Synonyms=Alpha Gamma; IsoId=P27699-10; Sequence=VSP_000602, VSP_000605, VSP_000606, VSP_000607; Name=11; Synonyms=Icer Gamma; IsoId=P27699-11; Sequence=VSP_055987, VSP_000607; Expressed in the testis. In premeiotic germ cells, expressed at low amounts in the antagonist form. Subsequently, during spermatogenesis, isoform 1 (activator) is generated exclusively and in extremely high amounts. Isoform 11 is expressed in a circadian manner in the adrenal gland with an expression peak at ZT20 (at protein level). It is induced by cAMP in an immediate-early fashion and can repress its own production via a negative autoregulatory mechanism. Stimulated by phosphorylation (By similarity). Phosphorylated on Ser-116 by TSSK4 in vitro. Ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome. CREM-null deficient mice display male infertility: while spermatogonia differentiate normally into round spermatids, all the elongating spermatids are eliminated by apoptosis during spermiogenesis. [Isoform 11]: Produced by alternative promoter usage. Belongs to the bZIP family. Sequence=AAA17495.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAA17496.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAA17497.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAV28551.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAV28552.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAV28553.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAV28554.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAV28555.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAV28556.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex cytoplasm glucose metabolic process regulation of transcription, DNA-templated fatty acid metabolic process glycosphingolipid metabolic process spermatogenesis circadian rhythm circadian regulation of gene expression regulation of circadian rhythm negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway rhythmic process response to cAMP uc033hfn.1 uc033hfn.2 uc033hfn.3 
ENSMUST00000150268.8 Plrg1 ENSMUST00000150268.8 pleiotropic regulator 1 (from RefSeq NM_016784.3) ENSMUST00000150268.1 ENSMUST00000150268.2 ENSMUST00000150268.3 ENSMUST00000150268.4 ENSMUST00000150268.5 ENSMUST00000150268.6 ENSMUST00000150268.7 NM_016784 O55039 PLRG1_MOUSE Q922V4 uc008ppi.1 uc008ppi.2 uc008ppi.3 Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its WD40 repeat domain) directly with CDC5L (via its C-terminal); the interaction is required for mRNA splicing but not for spliceosome assembly. Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with CRIPT (By similarity). Also interacts directly in the complex with BCAS2 and PRPF19. Interacts with USB1 (By similarity). Nucleus Nucleus speckle Belongs to the WD repeat PRL1/PRL2 family. mRNA splicing, via spliceosome Prp19 complex fibrillar center molecular_function nucleus DNA replication factor A complex spliceosomal complex mRNA processing RNA splicing nuclear speck nuclear membrane protein localization to nucleus U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome Cul4-RING E3 ubiquitin ligase complex positive regulation of G1/S transition of mitotic cell cycle uc008ppi.1 uc008ppi.2 uc008ppi.3 
ENSMUST00000150285.8 Slc35d1 ENSMUST00000150285.8 solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1, transcript variant 2 (from RefSeq NM_177732.5) A2AKQ0 ENSMUST00000150285.1 ENSMUST00000150285.2 ENSMUST00000150285.3 ENSMUST00000150285.4 ENSMUST00000150285.5 ENSMUST00000150285.6 ENSMUST00000150285.7 NM_177732 Q3TE90 Q5DU40 Q8BKX2 Q8BX24 S35D1_MOUSE Slc35d1 uc008txk.1 uc008txk.2 uc008txk.3 Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for either their cognate nucleoside monophosphate or another nucleotide sugar (By similarity). Transports various UDP-sugars including UDP-N-acetyl- alpha-D-glucosamine (UDP-GlcNAc), UDP-N-acetyl-alpha-D-galactosamine (UDP-GalNAc) and UDP-alpha-D-glucuronate (UDP-GlcA), which are used by ER glucosyltransferases as sugar donors for the synthesis of sugar chains of glycoproteins, glycolipids and oligosaccharides (By similarity). May couple UDP-GlcNAc or UDP-GalNAc efflux to UDP-GlcA influx into the ER lumen that in turn stimulates glucuronidation and subsequent excretion of endobiotics and xenobiotics (By similarity). Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development. Reaction=UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D- glucosamine(in) = UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D- glucosamine(out); Xref=Rhea:RHEA:73703, ChEBI:CHEBI:57705, ChEBI:CHEBI:58052; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:73704; Evidence=; Reaction=UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D- galactosamine(in) = UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha- D-galactosamine(out); Xref=Rhea:RHEA:74835, ChEBI:CHEBI:58052, ChEBI:CHEBI:67138; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74836; Evidence=; Reaction=UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) = UDP-N- acetyl-alpha-D-glucosamine(out) + UMP(in); Xref=Rhea:RHEA:72695, ChEBI:CHEBI:57705, ChEBI:CHEBI:57865; Evidence=; Reaction=UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) = UDP-N- acetyl-alpha-D-galactosamine(out) + UMP(in); Xref=Rhea:RHEA:72735, ChEBI:CHEBI:57865, ChEBI:CHEBI:67138; Evidence=; Reaction=UDP-alpha-D-glucuronate(in) + UMP(out) = UDP-alpha-D- glucuronate(out) + UMP(in); Xref=Rhea:RHEA:72727, ChEBI:CHEBI:57865, ChEBI:CHEBI:58052; Evidence=; Reaction=UDP-alpha-D-galactose(in) + UMP(out) = UDP-alpha-D- galactose(out) + UMP(in); Xref=Rhea:RHEA:72703, ChEBI:CHEBI:57865, ChEBI:CHEBI:66914; Evidence=; Reaction=UDP-alpha-D-glucose(in) + UMP(out) = UDP-alpha-D-glucose(out) + UMP(in); Xref=Rhea:RHEA:72731, ChEBI:CHEBI:57865, ChEBI:CHEBI:58885; Evidence=; Reaction=UDP-alpha-D-xylose(in) + UMP(out) = UDP-alpha-D-xylose(out) + UMP(in); Xref=Rhea:RHEA:72723, ChEBI:CHEBI:57632, ChEBI:CHEBI:57865; Evidence=; Reaction=UDP-beta-L-arabinopyranose(in) + UMP(out) = UDP-beta-L- arabinopyranose(out) + UMP(in); Xref=Rhea:RHEA:74671, ChEBI:CHEBI:57865, ChEBI:CHEBI:61457; Evidence=; Reaction=UDP-beta-L-arabinofuranose(in) + UMP(out) = UDP-beta-L- arabinofuranose(out) + UMP(in); Xref=Rhea:RHEA:74679, ChEBI:CHEBI:57865, ChEBI:CHEBI:61463; Evidence=; Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AKQ0-1; Sequence=Displayed; Name=2; IsoId=A2AKQ0-2; Sequence=VSP_059020; Neonatal lethality. Skeletal development is severely impaired leading to reduced snout and body length, and extremely short limbs. The proliferating zone of epiphyseal cartilage is disorganized with densely packed round chondrocytes and little extracellular matrix, in contrast to the regular columnar organization of chondrocytes in wild type cartilage. Chondroitin sulfate content of cartilage is significantly reduced, associated with reduced proteoglycan aggregates in the extracellular matrix. Belongs to the TPT transporter family. SLC35D subfamily. It is uncertain whether Met-1 or Met-31 is the initiator. UDP-glucuronic acid transmembrane transporter activity UDP-N-acetylglucosamine transmembrane transporter activity UDP-N-acetylgalactosamine transmembrane transporter activity endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus carbohydrate transport pyrimidine nucleotide-sugar transmembrane transporter activity antiporter activity UDP-glucuronic acid transport UDP-N-acetylgalactosamine transport membrane integral component of membrane transmembrane transporter activity chondroitin sulfate biosynthetic process embryonic skeletal system development pyrimidine nucleotide-sugar transmembrane transport UDP-N-acetylglucosamine transmembrane transport uc008txk.1 uc008txk.2 uc008txk.3 
ENSMUST00000150314.2 Plxna4os1 ENSMUST00000150314.2 plexin A4, opposite strand 1 (from RefSeq NR_040277.1) ENSMUST00000150314.1 NR_040277 uc009bgn.1 uc009bgn.2 uc009bgn.3 uc009bgn.4 uc009bgn.1 uc009bgn.2 uc009bgn.3 uc009bgn.4 
ENSMUST00000150329.2 Egfros ENSMUST00000150329.2 Egfros (from geneSymbol) AK087607 ENSMUST00000150329.1 uc287wsv.1 uc287wsv.2 uc287wsv.1 uc287wsv.2 
ENSMUST00000150350.9 Rpl13a ENSMUST00000150350.9 ribosomal protein L13A (from RefSeq NM_009438.5) ENSMUST00000150350.1 ENSMUST00000150350.2 ENSMUST00000150350.3 ENSMUST00000150350.4 ENSMUST00000150350.5 ENSMUST00000150350.6 ENSMUST00000150350.7 ENSMUST00000150350.8 NM_009438 Q5M9M0 Q5M9M0_MOUSE Rpl13a uc009gtk.1 uc009gtk.2 uc009gtk.3 uc009gtk.4 Belongs to the universal ribosomal protein uL13 family. structural constituent of ribosome ribosome translation large ribosomal subunit uc009gtk.1 uc009gtk.2 uc009gtk.3 uc009gtk.4 
ENSMUST00000150367.4 A330041J22Rik ENSMUST00000150367.4 RIKEN cDNA A330041J22 gene (from RefSeq NR_045835.1) ENSMUST00000150367.1 ENSMUST00000150367.2 ENSMUST00000150367.3 NR_045835 uc009qxt.1 uc009qxt.2 uc009qxt.3 uc009qxt.4 uc009qxt.5 uc009qxt.6 uc009qxt.1 uc009qxt.2 uc009qxt.3 uc009qxt.4 uc009qxt.5 uc009qxt.6 
ENSMUST00000150382.4 C030047K22Rik ENSMUST00000150382.4 C030047K22Rik (from geneSymbol) AK021157 ENSMUST00000150382.1 ENSMUST00000150382.2 ENSMUST00000150382.3 uc288xdj.1 uc288xdj.2 uc288xdj.1 uc288xdj.2 
ENSMUST00000150384.3 Lbhd2 ENSMUST00000150384.3 LBH domain containing 2, transcript variant 1 (from RefSeq NM_001358956.1) A230065H16Rik ENSMUST00000150384.1 ENSMUST00000150384.2 G3UW55 G3UW55_MOUSE Lbhd2 NM_001358956 uc007pcu.1 uc007pcu.2 uc007pcu.3 molecular_function cellular_component biological_process uc007pcu.1 uc007pcu.2 uc007pcu.3 
ENSMUST00000150385.2 Gm16036 ENSMUST00000150385.2 Gm16036 (from geneSymbol) AK139684 ENSMUST00000150385.1 uc291bji.1 uc291bji.2 uc291bji.1 uc291bji.2 
ENSMUST00000150388.3 Gm28052 ENSMUST00000150388.3 Gm28052 (from geneSymbol) AK005044 ENSMUST00000150388.1 ENSMUST00000150388.2 uc289jkx.1 uc289jkx.2 uc289jkx.1 uc289jkx.2 
ENSMUST00000150389.3 Gm15764 ENSMUST00000150389.3 Gm15764 (from geneSymbol) BC046487 ENSMUST00000150389.1 ENSMUST00000150389.2 uc289ddu.1 uc289ddu.2 uc289ddu.3 uc289ddu.1 uc289ddu.2 uc289ddu.3 
ENSMUST00000150412.4 Pakap ENSMUST00000150412.4 paralemmin A kinase anchor protein, transcript variant 8 (from RefSeq NM_001384157.1) ENSMUST00000150412.1 ENSMUST00000150412.2 ENSMUST00000150412.3 F7AA26 F7AA26_MOUSE NM_001384157 Pakap uc290mxf.1 uc290mxf.2 This locus represents naturally occurring readthrough transcription between the neighboring Palm2 (paralemmin 2) and Akap2 (A kinase (PRKA) anchor protein 2) genes on chromosome 4. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Similar readthrough transcription has also been observed in human, as described in PMID: 11478809. [provided by RefSeq, Feb 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849387, SAMN00849390 [ECO:0000348] ##Evidence-Data-END## actin filament organization transmembrane receptor protein serine/threonine kinase signaling pathway protein localization regulation of cell shape membrane protein kinase A binding uc290mxf.1 uc290mxf.2 
ENSMUST00000150434.8 Brwd3 ENSMUST00000150434.8 bromodomain and WD repeat domain containing 3 (from RefSeq NM_001081477.2) A2AHJ4 BRWD3_MOUSE ENSMUST00000150434.1 ENSMUST00000150434.2 ENSMUST00000150434.3 ENSMUST00000150434.4 ENSMUST00000150434.5 ENSMUST00000150434.6 ENSMUST00000150434.7 Gm596 NM_001081477 Q3TQR7 Q3UTB6 Q640P3 Q8C7D5 uc009ucm.1 uc009ucm.2 uc009ucm.3 Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AHJ4-1; Sequence=Displayed; Name=2; IsoId=A2AHJ4-2; Sequence=VSP_024310, VSP_024311; Name=3; IsoId=A2AHJ4-3; Sequence=VSP_024308, VSP_024309; molecular_function nucleus regulation of transcription from RNA polymerase II promoter cytoskeleton organization regulation of cell shape uc009ucm.1 uc009ucm.2 uc009ucm.3 
ENSMUST00000150442.2 Gm11642 ENSMUST00000150442.2 Gm11642 (from geneSymbol) ENSMUST00000150442.1 uc288cun.1 uc288cun.2 uc288cun.1 uc288cun.2 
ENSMUST00000150450.2 Gm13883 ENSMUST00000150450.2 Gm13883 (from geneSymbol) BC042716 ENSMUST00000150450.1 uc289yxx.1 uc289yxx.2 uc289yxx.1 uc289yxx.2 
ENSMUST00000150459.3 1500009L16Rik ENSMUST00000150459.3 RIKEN cDNA 1500009L16 gene (from RefSeq NM_001145198.1) ENSMUST00000150459.1 ENSMUST00000150459.2 NM_001145198 OCC1_MOUSE P0C913 uc007gkm.1 uc007gkm.2 uc007gkm.3 Belongs to the OCC1 family. molecular_function cellular_component biological_process uc007gkm.1 uc007gkm.2 uc007gkm.3 
ENSMUST00000150471.2 Dhrs13os ENSMUST00000150471.2 dehydrogenase/reductase 13, opposite strand (from RefSeq NR_152257.1) ENSMUST00000150471.1 NR_152257 uc288alw.1 uc288alw.2 uc288alw.1 uc288alw.2 
ENSMUST00000150482.2 Gm13780 ENSMUST00000150482.2 Gm13780 (from geneSymbol) ENSMUST00000150482.1 uc289ymr.1 uc289ymr.2 uc289ymr.1 uc289ymr.2 
ENSMUST00000150488.8 Wdr17 ENSMUST00000150488.8 WD repeat domain 17, transcript variant 2 (from RefSeq NM_001172152.2) ENSMUST00000150488.1 ENSMUST00000150488.2 ENSMUST00000150488.3 ENSMUST00000150488.4 ENSMUST00000150488.5 ENSMUST00000150488.6 ENSMUST00000150488.7 NM_001172152 Q8C8Y2 Q8C8Y2_MOUSE Wdr17 uc009lsi.1 uc009lsi.2 uc009lsi.3 uc009lsi.4 uc009lsi.5 molecular_function biological_process uc009lsi.1 uc009lsi.2 uc009lsi.3 uc009lsi.4 uc009lsi.5 
ENSMUST00000150536.2 Gm11417 ENSMUST00000150536.2 Gm11417 (from geneSymbol) ENSMUST00000150536.1 uc288atk.1 uc288atk.2 uc288atk.1 uc288atk.2 
ENSMUST00000150544.2 Gm14573 ENSMUST00000150544.2 Gm14573 (from geneSymbol) ENSMUST00000150544.1 uc291hcj.1 uc291hcj.2 uc291hcj.1 uc291hcj.2 
ENSMUST00000150559.2 1700060C16Rik ENSMUST00000150559.2 RIKEN cDNA 1700060C16 gene (from RefSeq NR_045732.1) ENSMUST00000150559.1 NR_045732 uc029wcp.1 uc029wcp.2 uc029wcp.1 uc029wcp.2 
ENSMUST00000150576.8 Rpl29 ENSMUST00000150576.8 Cytoplasm (from UniProt Q5M8M8) AK141477 D3Z1N9 ENSMUST00000150576.1 ENSMUST00000150576.2 ENSMUST00000150576.3 ENSMUST00000150576.4 ENSMUST00000150576.5 ENSMUST00000150576.6 ENSMUST00000150576.7 Q5M8M8 Q5M8M8_MOUSE Rpl29 uc009rjn.1 uc009rjn.2 uc009rjn.3 uc009rjn.4 Cytoplasm Belongs to the eukaryotic ribosomal protein eL29 family. structural constituent of ribosome ribosome translation uc009rjn.1 uc009rjn.2 uc009rjn.3 uc009rjn.4 
ENSMUST00000150600.2 Gm15423 ENSMUST00000150600.2 Gm15423 (from geneSymbol) AK047024 ENSMUST00000150600.1 uc287ofm.1 uc287ofm.2 uc287ofm.1 uc287ofm.2 
ENSMUST00000150616.2 Gm15948 ENSMUST00000150616.2 Gm15948 (from geneSymbol) ENSMUST00000150616.1 uc290wbd.1 uc290wbd.2 uc290wbd.1 uc290wbd.2 
ENSMUST00000150639.2 Dact1 ENSMUST00000150639.2 dishevelled-binding antagonist of beta-catenin 1, transcript variant 1 (from RefSeq NM_001190466.1) D3Z5V0 D3Z5V0_MOUSE Dact1 ENSMUST00000150639.1 NM_001190466 uc007nuq.1 uc007nuq.2 uc007nuq.3 uc007nuq.4 Cytoplasm Belongs to the dapper family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding nucleus nucleoplasm cytoplasm beta-catenin binding neural tube development positive regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway beta-catenin destruction complex regulation of protein stability negative regulation of protein binding positive regulation of protein binding histone deacetylase binding positive regulation of protein catabolic process negative regulation of JNK cascade protein kinase A binding regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of cellular protein catabolic process negative regulation of beta-catenin-TCF complex assembly negative regulation of G1/S transition of mitotic cell cycle uc007nuq.1 uc007nuq.2 uc007nuq.3 uc007nuq.4 
ENSMUST00000150649.9 Ifi213 ENSMUST00000150649.9 interferon activated gene 213, transcript variant 4 (from RefSeq NM_001368799.1) D3Z5G0 D3Z5G0_MOUSE ENSMUST00000150649.1 ENSMUST00000150649.2 ENSMUST00000150649.3 ENSMUST00000150649.4 ENSMUST00000150649.5 ENSMUST00000150649.6 ENSMUST00000150649.7 ENSMUST00000150649.8 Ifi213 NM_001368799 Pydc4 uc287oar.1 uc287oar.2 Belongs to the HIN-200 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding activation of innate immune response double-stranded DNA binding nucleus nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding uc287oar.1 uc287oar.2 
ENSMUST00000150678.2 Gm9888 ENSMUST00000150678.2 Gm9888 (from geneSymbol) AK042275 ENSMUST00000150678.1 uc292lyj.1 uc292lyj.2 uc292lyj.1 uc292lyj.2 
ENSMUST00000150690.2 Gm15239 ENSMUST00000150690.2 predicted gene 15239 (from RefSeq NR_189046.1) ENSMUST00000150690.1 NR_189046 uc009uxe.1 uc009uxe.2 uc009uxe.3 uc009uxe.1 uc009uxe.2 uc009uxe.3 
ENSMUST00000150702.3 Erich2os ENSMUST00000150702.3 Erich2os (from geneSymbol) ENSMUST00000150702.1 ENSMUST00000150702.2 uc289wsq.1 uc289wsq.2 uc289wsq.3 uc289wsq.1 uc289wsq.2 uc289wsq.3 
ENSMUST00000150727.8 Ube2e2 ENSMUST00000150727.8 ubiquitin-conjugating enzyme E2E 2, transcript variant 1 (from RefSeq NM_144839.2) ENSMUST00000150727.1 ENSMUST00000150727.2 ENSMUST00000150727.3 ENSMUST00000150727.4 ENSMUST00000150727.5 ENSMUST00000150727.6 ENSMUST00000150727.7 NM_144839 Q91W82 UB2E2_MOUSE uc007shv.1 uc007shv.2 uc007shv.3 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence= Protein modification; protein ubiquitination. Autoubiquitinated. Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding ubiquitin-protein transferase activity ATP binding cellular response to DNA damage stimulus protein ubiquitination transferase activity ISG15-protein conjugation ISG15 transferase activity ubiquitin conjugating enzyme activity protein K63-linked ubiquitination protein K48-linked ubiquitination protein K11-linked ubiquitination positive regulation of G1/S transition of mitotic cell cycle uc007shv.1 uc007shv.2 uc007shv.3 
ENSMUST00000150749.4 2810408I11Rik ENSMUST00000150749.4 2810408I11Rik (from geneSymbol) AK013046 ENSMUST00000150749.1 ENSMUST00000150749.2 ENSMUST00000150749.3 uc007bgw.1 uc007bgw.2 uc007bgw.3 uc007bgw.4 uc007bgw.5 uc007bgw.6 uc007bgw.1 uc007bgw.2 uc007bgw.3 uc007bgw.4 uc007bgw.5 uc007bgw.6 
ENSMUST00000150754.2 Gm12862 ENSMUST00000150754.2 Gm12862 (from geneSymbol) ENSMUST00000150754.1 uc290pji.1 uc290pji.2 uc290pji.1 uc290pji.2 
ENSMUST00000150768.8 Kctd9 ENSMUST00000150768.8 potassium channel tetramerisation domain containing 9, transcript variant 1 (from RefSeq NM_001111028.1) E9PUA6 E9PUA6_MOUSE ENSMUST00000150768.1 ENSMUST00000150768.2 ENSMUST00000150768.3 ENSMUST00000150768.4 ENSMUST00000150768.5 ENSMUST00000150768.6 ENSMUST00000150768.7 Kctd9 NM_001111028 uc011znv.1 uc011znv.2 uc011znv.3 intracellular signal transduction identical protein binding protein self-association protein homooligomerization cullin family protein binding uc011znv.1 uc011znv.2 uc011znv.3 
ENSMUST00000150779.8 Msi1 ENSMUST00000150779.8 musashi RNA-binding protein 1, transcript variant 1 (from RefSeq NM_008629.2) ENSMUST00000150779.1 ENSMUST00000150779.2 ENSMUST00000150779.3 ENSMUST00000150779.4 ENSMUST00000150779.5 ENSMUST00000150779.6 ENSMUST00000150779.7 MSI1H_MOUSE Msi1h NM_008629 Q61474 Q8BNC7 uc008zdv.1 uc008zdv.2 uc008zdv.3 RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU- 3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system. Q61474; Q61474: Msi1; NbExp=2; IntAct=EBI-8327453, EBI-8327453; Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61474-1; Sequence=Displayed; Name=2; IsoId=Q61474-2; Sequence=VSP_011166, VSP_011167; Expressed in neural stem and progenitor cells (at protein level) (PubMed:16554442). Detected in olfactory bulb, brain stem, small intestine, and at low levels in brain cortex, hippocampus and ovary (PubMed:8660864). Detected in neural progenitor cells, including neural stem cells (PubMed:8660864). Highly expressed in embryonic brain at day 12. Expressed at intermediate levels during the rest of embryonic development and in newborns up to day 3. After this expression decreases and stabilizes at low levels of expression around day 13. The first RNA recognition motif binds more strongly to RNA compared to the second one. Belongs to the Musashi family. nucleic acid binding RNA binding single-stranded RNA binding nucleus cytoplasm cytosol polysome poly(U) RNA binding response to hormone identical protein binding ribonucleoprotein complex uc008zdv.1 uc008zdv.2 uc008zdv.3 
ENSMUST00000150782.4 Atcayos ENSMUST00000150782.4 Atcayos (from geneSymbol) AK136697 ENSMUST00000150782.1 ENSMUST00000150782.2 ENSMUST00000150782.3 uc029raf.1 uc029raf.2 uc029raf.3 uc029raf.4 uc029raf.5 uc029raf.1 uc029raf.2 uc029raf.3 uc029raf.4 uc029raf.5 
ENSMUST00000150818.3 Gm11515 ENSMUST00000150818.3 Gm11515 (from geneSymbol) ENSMUST00000150818.1 ENSMUST00000150818.2 uc288boc.1 uc288boc.2 uc288boc.3 uc288boc.1 uc288boc.2 uc288boc.3 
ENSMUST00000150819.3 AI661453 ENSMUST00000150819.3 expressed sequence AI661453 (from RefSeq NM_145489.2) CF132_MOUSE ENSMUST00000150819.1 ENSMUST00000150819.2 NM_145489 Q8K108 Q91Z58 uc008cvg.1 uc008cvg.2 uc008cvg.3 uc008cvg.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91Z58-1; Sequence=Displayed; Name=2; IsoId=Q91Z58-2; Sequence=VSP_034436, VSP_034437; molecular_function cellular_component biological_process uc008cvg.1 uc008cvg.2 uc008cvg.3 uc008cvg.4 
ENSMUST00000150843.9 Pank2 ENSMUST00000150843.9 pantothenate kinase 2, transcript variant 1 (from RefSeq NM_153501.3) ENSMUST00000150843.1 ENSMUST00000150843.2 ENSMUST00000150843.3 ENSMUST00000150843.4 ENSMUST00000150843.5 ENSMUST00000150843.6 ENSMUST00000150843.7 ENSMUST00000150843.8 NM_153501 PANK2_MOUSE Q3U4S0 Q7M753 uc008mlg.1 uc008mlg.2 uc008mlg.3 Catalyzes the phosphorylation of pantothenate to generate 4'- phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Reaction=(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+); Xref=Rhea:RHEA:16373, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=2.7.1.33; Evidence= Inhibited by acetyl-CoA (PubMed:17825826). Inhibited by calcium hopantenate (PubMed:17379144). Activated by palmitoylcarnitine (PubMed:17825826). Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 1/5. Homodimer. Cytoplasm, cytosol Single knockout mice show a reduction in pantothenate kinase (PANK) activity of about 30% and 60% in the liver and brain respectively. Pank1 and Pank2 double knockout mice develop progressively severe hypoglycemia and hyperketonemia by postnatal day 10 leading to their death by day 17. A reduction in PANK activity of about 90-95% seen in the liver and brain and hepatocytes show reduced NADH levels. Belongs to the type II pantothenate kinase family. Sequence=AAI06185.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE32361.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; pantothenate kinase activity ATP binding nucleus mitochondrion mitochondrial intermembrane space cytosol spermatid development aerobic respiration coenzyme A biosynthetic process kinase activity phosphorylation regulation of fatty acid metabolic process regulation of mitochondrial membrane potential mitochondrion morphogenesis regulation of triglyceride metabolic process regulation of bile acid metabolic process uc008mlg.1 uc008mlg.2 uc008mlg.3 
ENSMUST00000150844.3 Eri2 ENSMUST00000150844.3 exoribonuclease 2, transcript variant 1 (from RefSeq NM_027698.5) ENSMUST00000150844.1 ENSMUST00000150844.2 ERI2_MOUSE Exod1 Kiaa1504 NM_027698 Q3TUK9 Q5BKS4 Q8C133 uc009jlu.1 uc009jlu.2 uc009jlu.3 uc009jlu.4 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions per subunit. ; Belongs to the ERI2 family. 3'-5'-exoribonuclease activity nucleic acid binding nuclease activity exonuclease activity DNA metabolic process zinc ion binding single-stranded DNA 3'-5' exodeoxyribonuclease activity hydrolase activity metal ion binding nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic uc009jlu.1 uc009jlu.2 uc009jlu.3 uc009jlu.4 
ENSMUST00000150889.4 Gm16046 ENSMUST00000150889.4 Gm16046 (from geneSymbol) AK143195 ENSMUST00000150889.1 ENSMUST00000150889.2 ENSMUST00000150889.3 uc008aml.1 uc008aml.2 uc008aml.3 uc008aml.4 uc008aml.5 uc008aml.6 uc008aml.1 uc008aml.2 uc008aml.3 uc008aml.4 uc008aml.5 uc008aml.6 
ENSMUST00000150895.2 Gm12171 ENSMUST00000150895.2 Gm12171 (from geneSymbol) ENSMUST00000150895.1 uc287xqe.1 uc287xqe.2 uc287xqe.1 uc287xqe.2 
ENSMUST00000150897.8 Nuggc ENSMUST00000150897.8 Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (By similarity). Reduces somatic hypermutation in B-cells which may enhance genome stability (PubMed:22833677). (from UniProt D3YWJ0) D3YWJ0 ENSMUST00000150897.1 ENSMUST00000150897.2 ENSMUST00000150897.3 ENSMUST00000150897.4 ENSMUST00000150897.5 ENSMUST00000150897.6 ENSMUST00000150897.7 Nuggc SLIP_MOUSE uc288vfo.1 uc288vfo.2 Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (By similarity). Reduces somatic hypermutation in B-cells which may enhance genome stability (PubMed:22833677). Nucleus speckle B-cell and T-cell development is unaffected, and germinal centers form normally. Class-switch recombination in B-cells is not affected. B-cells in older mice (3 months onwards) show significantly increased somatic hypermutation near the immunoglobulin heavy chain locus, mainly at G:C base pairs. Other loci also show increased rates of somatic hypermutation. nucleotide binding GTPase activity GTP binding nucleus cellular response to DNA damage stimulus somatic hypermutation of immunoglobulin genes nuclear speck hydrolase activity regulation of nuclear cell cycle DNA replication negative regulation of apoptotic process cellular response to lipopolysaccharide uc288vfo.1 uc288vfo.2 
ENSMUST00000150973.2 A630014C17Rik ENSMUST00000150973.2 A630014C17Rik (from geneSymbol) AK041482 ENSMUST00000150973.1 uc287ybd.1 uc287ybd.2 uc287ybd.1 uc287ybd.2 
ENSMUST00000151004.2 4930444P10Rik ENSMUST00000151004.2 RIKEN cDNA 4930444P10 gene, transcript variant 2 (from RefSeq NM_001243238.2) 4930444P10Rik D3YUR1 ENSMUST00000151004.1 F6QJK4 F6QJK4_MOUSE J3QPK3 NM_001243238 uc029qmy.1 uc029qmy.2 uc029qmy.3 molecular_function cellular_component biological_process uc029qmy.1 uc029qmy.2 uc029qmy.3 
ENSMUST00000151014.3 Gm15418 ENSMUST00000151014.3 Gm15418 (from geneSymbol) ENSMUST00000151014.1 ENSMUST00000151014.2 uc291ycu.1 uc291ycu.2 uc291ycu.3 uc291ycu.1 uc291ycu.2 uc291ycu.3 
ENSMUST00000151029.3 Gpr141b ENSMUST00000151029.3 G protein-coupled receptor 141B (from RefSeq NM_175688.4) A530099J19Rik B9EKH0 B9EKH0_MOUSE ENSMUST00000151029.1 ENSMUST00000151029.2 Gpr141b NM_175688 uc288lcy.1 uc288lcy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity cellular_component G-protein coupled receptor signaling pathway membrane integral component of membrane uc288lcy.1 uc288lcy.2 
ENSMUST00000151032.3 1700042O10Rik ENSMUST00000151032.3 RIKEN cDNA 1700042O10 gene (from RefSeq NR_045178.1) ENSMUST00000151032.1 ENSMUST00000151032.2 NR_045178 uc007iay.1 uc007iay.2 uc007iay.3 uc007iay.4 uc007iay.1 uc007iay.2 uc007iay.3 uc007iay.4 
ENSMUST00000151101.3 Gm15243 ENSMUST00000151101.3 Gm15243 (from geneSymbol) ENSMUST00000151101.1 ENSMUST00000151101.2 uc292rnr.1 uc292rnr.2 uc292rnr.3 uc292rnr.1 uc292rnr.2 uc292rnr.3 
ENSMUST00000151120.9 Ctsd ENSMUST00000151120.9 cathepsin D (from RefSeq NM_009983.3) Ctsd ENSMUST00000151120.1 ENSMUST00000151120.2 ENSMUST00000151120.3 ENSMUST00000151120.4 ENSMUST00000151120.5 ENSMUST00000151120.6 ENSMUST00000151120.7 ENSMUST00000151120.8 NM_009983 Q3UCD9 Q3UCD9_MOUSE uc009kmv.1 uc009kmv.2 uc009kmv.3 Reaction=Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.; EC=3.4.23.5; Evidence=; Lysosome Belongs to the peptidase A1 family. aspartic-type endopeptidase activity lysosome proteolysis peptidase activity hydrolase activity uc009kmv.1 uc009kmv.2 uc009kmv.3 
ENSMUST00000151136.2 Gm10501 ENSMUST00000151136.2 Gm10501 (from geneSymbol) AK134269 ENSMUST00000151136.1 uc289kjb.1 uc289kjb.2 uc289kjb.1 uc289kjb.2 
ENSMUST00000151188.3 Gm15348 ENSMUST00000151188.3 predicted gene 15348 (from RefSeq NR_033546.1) ENSMUST00000151188.1 ENSMUST00000151188.2 NR_033546 uc012fzq.1 uc012fzq.2 uc012fzq.3 uc012fzq.1 uc012fzq.2 uc012fzq.3 
ENSMUST00000151189.2 Tmed7 ENSMUST00000151189.2 transmembrane p24 trafficking protein 7 (from RefSeq NM_025698.1) D3YZZ5 D3YZZ5_MOUSE ENSMUST00000151189.1 NM_025698 Tmed7 uc008evr.1 uc008evr.2 uc008evr.3 uc008evr.4 Endoplasmic reticulum membrane ; Single-pass type I membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein Golgi apparatus, cis-Golgi network membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the EMP24/GP25L family. molecular_function endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus intracellular protein transport ER to Golgi vesicle-mediated transport Golgi organization membrane integral component of membrane ER to Golgi transport vesicle uc008evr.1 uc008evr.2 uc008evr.3 uc008evr.4 
ENSMUST00000151215.3 4933407I08Rik ENSMUST00000151215.3 4933407I08Rik (from geneSymbol) AK016724 ENSMUST00000151215.1 ENSMUST00000151215.2 uc289oys.1 uc289oys.2 uc289oys.3 uc289oys.1 uc289oys.2 uc289oys.3 
ENSMUST00000151216.2 Gm12867 ENSMUST00000151216.2 Gm12867 (from geneSymbol) ENSMUST00000151216.1 uc290pjn.1 uc290pjn.2 uc290pjn.1 uc290pjn.2 
ENSMUST00000151217.9 1110018N20Rik ENSMUST00000151217.9 1110018N20Rik (from geneSymbol) AY672066 ENSMUST00000151217.1 ENSMUST00000151217.2 ENSMUST00000151217.3 ENSMUST00000151217.4 ENSMUST00000151217.5 ENSMUST00000151217.6 ENSMUST00000151217.7 ENSMUST00000151217.8 uc008nzj.1 uc008nzj.2 uc008nzj.3 uc008nzj.4 uc008nzj.1 uc008nzj.2 uc008nzj.3 uc008nzj.4 
ENSMUST00000151224.3 Fam163b ENSMUST00000151224.3 family with sequence similarity 163, member B (from RefSeq NM_175427.4) ENSMUST00000151224.1 ENSMUST00000151224.2 F163B_MOUSE NM_175427 Q8BUM6 uc008ixc.1 uc008ixc.2 uc008ixc.3 uc008ixc.4 Membrane ; Single-pass membrane protein Belongs to the FAM163 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008ixc.1 uc008ixc.2 uc008ixc.3 uc008ixc.4 
ENSMUST00000151231.10 8030474K03Rik ENSMUST00000151231.10 8030474K03Rik (from geneSymbol) 8030474K03Rik AK033245 E9Q4Y8 E9Q4Y8_MOUSE ENSMUST00000151231.1 ENSMUST00000151231.2 ENSMUST00000151231.3 ENSMUST00000151231.4 ENSMUST00000151231.5 ENSMUST00000151231.6 ENSMUST00000151231.7 ENSMUST00000151231.8 ENSMUST00000151231.9 uc292pto.1 uc292pto.2 molecular_function cellular_component biological_process uc292pto.1 uc292pto.2 
ENSMUST00000151260.2 Gm14241 ENSMUST00000151260.2 Gm14241 (from geneSymbol) ENSMUST00000151260.1 uc290cgo.1 uc290cgo.2 uc290cgo.1 uc290cgo.2 
ENSMUST00000151266.8 Dgcr6 ENSMUST00000151266.8 DiGeorge syndrome critical region gene 6, transcript variant 4 (from RefSeq NR_110380.1) D3Z558 D3Z558_MOUSE Dgcr6 ENSMUST00000151266.1 ENSMUST00000151266.2 ENSMUST00000151266.3 ENSMUST00000151266.4 ENSMUST00000151266.5 ENSMUST00000151266.6 ENSMUST00000151266.7 NR_110380 uc007ymt.1 uc007ymt.2 uc007ymt.3 uc007ymt.4 This gene encodes a protein that is similar to the gonadal protein in Drosophila (fruit fly). The encoded protein is thought to play a role in migration of neural crest cells during development. Deletions in the human gene are associated with DiGeorge syndrome (or velocardiofacial syndrome) which has many clinical features including cardiac abnormalities, cleft palate, atypical facial features, hypocalcemia, hypoparathyroidism and defective development or congenital absence of the thymus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Belongs to the gonadal family. uc007ymt.1 uc007ymt.2 uc007ymt.3 uc007ymt.4 
ENSMUST00000151282.2 Gm11706 ENSMUST00000151282.2 Gm11706 (from geneSymbol) ENSMUST00000151282.1 uc288dbg.1 uc288dbg.2 uc288dbg.1 uc288dbg.2 
ENSMUST00000151287.8 Tcp1 ENSMUST00000151287.8 t-complex protein 1, transcript variant 1 (from RefSeq NM_013686.4) Cct1 Ccta ENSMUST00000151287.1 ENSMUST00000151287.2 ENSMUST00000151287.3 ENSMUST00000151287.4 ENSMUST00000151287.5 ENSMUST00000151287.6 ENSMUST00000151287.7 NM_013686 P11983 P11984 Q3TJ96 Q3TKU1 Q3U5T8 Q3U7I8 Q3UAA8 Q3UB80 Q3UE48 TCPA_MOUSE uc008all.1 uc008all.2 uc008all.3 uc008all.4 Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Interacts with GBA1 (By similarity). Interacts with DLEC1 (By similarity). Cytoplasm, cytosol Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11983-1; Sequence=Displayed; Name=2; IsoId=P11983-2; Sequence=VSP_024734, VSP_024735; Belongs to the TCP-1 chaperonin family. Sequence=AAA40337.1; Type=Frameshift; Evidence=; Sequence=AAA40338.1; Type=Frameshift; Evidence=; nucleotide binding pericentriolar material heterochromatin acrosomal vesicle zona pellucida receptor complex protein binding ATP binding nuclear heterochromatin cytoplasm Golgi apparatus centrosome microtubule organizing center cytosol chaperonin-containing T-complex cytoskeleton microtubule protein folding binding of sperm to zona pellucida ubiquitin protein ligase binding positive regulation of telomere maintenance via telomerase myelin sheath translocation of peptides or proteins into host cell cytoplasm cell body protein stabilization unfolded protein binding positive regulation of telomerase activity scaRNA localization to Cajal body toxin transport positive regulation of establishment of protein localization to telomere positive regulation of telomerase RNA localization to Cajal body regulation of macrophage apoptotic process uc008all.1 uc008all.2 uc008all.3 uc008all.4 
ENSMUST00000151288.8 Slc45a4 ENSMUST00000151288.8 solute carrier family 45, member 4, transcript variant 1 (from RefSeq NM_001033219.4) ENSMUST00000151288.1 ENSMUST00000151288.2 ENSMUST00000151288.3 ENSMUST00000151288.4 ENSMUST00000151288.5 ENSMUST00000151288.6 ENSMUST00000151288.7 Kiaa1126 NM_001033219 Q0P5V9 Q3TCG5 Q3V0B8 Q69ZR4 Q6PDG3 S45A4_MOUSE uc007wch.1 uc007wch.2 uc007wch.3 uc007wch.4 uc007wch.5 Proton-associated sucrose transporter. May be able to transport also glucose and fructose. Reaction=H(+)(out) + sucrose(out) = H(+)(in) + sucrose(in); Xref=Rhea:RHEA:72187, ChEBI:CHEBI:15378, ChEBI:CHEBI:17992; Evidence=; Kinetic parameters: KM=6.3 mM for sucrose ; pH dependence: Optimum pH is 6.5. ; Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q0P5V9-1; Sequence=Displayed; Name=2; IsoId=Q0P5V9-2; Sequence=VSP_033544; Name=3; IsoId=Q0P5V9-3; Sequence=VSP_033543; Ubiquitously expressed. Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. sucrose:proton symporter activity sucrose transport membrane integral component of membrane uc007wch.1 uc007wch.2 uc007wch.3 uc007wch.4 uc007wch.5 
ENSMUST00000151309.8 Adgrb3 ENSMUST00000151309.8 adhesion G protein-coupled receptor B3 (from RefSeq NM_175642.4) AGRB3_MOUSE Bai3 ENSMUST00000151309.1 ENSMUST00000151309.2 ENSMUST00000151309.3 ENSMUST00000151309.4 ENSMUST00000151309.5 ENSMUST00000151309.6 ENSMUST00000151309.7 G3XA05 NM_175642 Q80ZF8 uc011wis.1 uc011wis.2 uc011wis.3 Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (PubMed:23628982). Promotes myoblast fusion through ELMO/DOCK1 (By similarity). Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts (via its TSRs) with C1QL1, C1QL2, C1QL3 and C1QL4. Interacts via (C- terminus) with ELMO1 (PubMed:23628982), ELMO2 and ELMO3. Cell membrane ; Multi-pass membrane protein Brain-specific expression. Limited to the central nervous system (CNS) at all developmental stages. Peaks 1 day after birth. The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. transmembrane signaling receptor activity G-protein coupled receptor activity GTPase activator activity protein binding plasma membrane integral component of plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway myoblast fusion membrane integral component of membrane neuron remodeling negative regulation of angiogenesis synaptic cleft positive regulation of GTPase activity regulation of dendrite morphogenesis positive regulation of synapse assembly motor learning postsynapse maintenance of synapse structure uc011wis.1 uc011wis.2 uc011wis.3 
ENSMUST00000151337.2 Gm13062 ENSMUST00000151337.2 Gm13062 (from geneSymbol) ENSMUST00000151337.1 uc290rlk.1 uc290rlk.2 uc290rlk.1 uc290rlk.2 
ENSMUST00000151367.3 4930577H14Rik ENSMUST00000151367.3 4930577H14Rik (from geneSymbol) AK019813 ENSMUST00000151367.1 ENSMUST00000151367.2 uc290nto.1 uc290nto.2 uc290nto.3 uc290nto.1 uc290nto.2 uc290nto.3 
ENSMUST00000151380.2 Hoxd8 ENSMUST00000151380.2 homeobox D8, transcript variant 3 (from RefSeq NM_001290731.2) ENSMUST00000151380.1 F6W963 F6W963_MOUSE Hoxd8 NM_001290731 uc056zni.1 uc056zni.2 uc056zni.3 uc056zni.4 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Nucleus Belongs to the Antp homeobox family. DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development sequence-specific DNA binding uc056zni.1 uc056zni.2 uc056zni.3 uc056zni.4 
ENSMUST00000151390.8 Tdg ENSMUST00000151390.8 thymine DNA glycosylase, transcript variant 2 (from RefSeq NM_172552.4) ENSMUST00000151390.1 ENSMUST00000151390.2 ENSMUST00000151390.3 ENSMUST00000151390.4 ENSMUST00000151390.5 ENSMUST00000151390.6 ENSMUST00000151390.7 NM_172552 P56581 Q3TPW4 Q542A9 Q5U3M4 Q5U3M5 Q6PJW4 Q8BPK0 TDG_MOUSE uc007gjr.1 uc007gjr.2 uc007gjr.3 uc007gjr.4 DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine (PubMed:21817016). Cannot remove 5- hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC (PubMed:21722948). Also involved in DNA repair by acting as a thymine- DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5- methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. Reaction=Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.; EC=3.2.2.29; Homodimer. Interacts with AICDA and GADD45A (By similarity). P56581; Q15788: NCOA1; Xeno; NbExp=4; IntAct=EBI-4320525, EBI-455189; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P56581-1; Sequence=Displayed; Name=2; IsoId=P56581-2; Sequence=VSP_046491; Sumoylation on Lys-341 by either SUMO1 or SUMO2 induces dissociation of the product DNA. Embryonic lethality between 10.5 and 12.5 dpc. Embryos display specific patterning defects of the developing heart; vasculogenesis defects of dorsal aortae, carotid arteries and branchial arteries. Global defects of angiogenesis are also observed. Defects are due to epigenetic aberrations affecting the expression of developmental genes, coincident with imbalanced histone modification and CpG methylation at promoters of affected genes. Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family. negative regulation of transcription from RNA polymerase II promoter magnesium ion binding DNA binding double-stranded DNA binding transcription cofactor activity uracil DNA N-glycosylase activity protein kinase C binding protein binding ATP binding nucleus nucleoplasm plasma membrane DNA repair base-excision repair base-excision repair, AP site formation mismatch repair chromatin organization cellular response to DNA damage stimulus transcription factor binding pyrimidine-specific mismatch base pair DNA N-glycosylase activity hydrolase activity DNA N-glycosylase activity protein domain specific binding mismatched DNA binding sodium ion binding chloride ion binding negative regulation of protein binding SUMO binding negative regulation of chromatin binding regulation of gene expression, epigenetic protein homodimerization activity protein self-association G/U mismatch-specific uracil-DNA glycosylase activity regulation of embryonic development DNA demethylation regulation of DNA N-glycosylase activity PML body uc007gjr.1 uc007gjr.2 uc007gjr.3 uc007gjr.4 
ENSMUST00000151408.9 Rasgrf2 ENSMUST00000151408.9 RAS protein-specific guanine nucleotide-releasing factor 2 (from RefSeq NM_009027.4) ENSMUST00000151408.1 ENSMUST00000151408.2 ENSMUST00000151408.3 ENSMUST00000151408.4 ENSMUST00000151408.5 ENSMUST00000151408.6 ENSMUST00000151408.7 ENSMUST00000151408.8 Grf2 NM_009027 P70392 Q3TYN3 Q9QX51 RGRF2_MOUSE uc288pcf.1 uc288pcf.2 Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. Homooligomer and heterooligomer with RASGRF1. Interacts with Ras and RAC1. Interacts in a calcium-dependent manner with calmodulin. Interacts with EPB49 and probably CDK5R1. Interacts with the AMPA receptor through GRIA1. Interacts with microtubules. Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). Expressed in brain in the nucleus of the solitary tract. Not observed in the hippocampus (at protein level). Expression increases in the cortex from birth to adulthood. The Ras-GEF domain and the N-terminal Ras-GEF domain form a Ras-binding site and mediate Ras activation. The IQ domain mediates the calcium-dependent interaction with calmodulin but is dispensable for the Ras-GEF activity. The DH (DBL-homology) domain mediates interaction with RASGRF1 and probably EPB49 and is required for RAC1 activation. Phosphorylated by CDK5; down-regulates RASGRF2-mediated RAC1 activation. Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome. Mice do not display overt phenotype. Preferentially activates HRAS in vivo compared to R-RAS based on their different types of prenylation. guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity calmodulin binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane small GTPase mediated signal transduction membrane response to endoplasmic reticulum stress regulation of Rho protein signal transduction regulation of Ras protein signal transduction long-term synaptic potentiation regulation of N-methyl-D-aspartate selective glutamate receptor activity uc288pcf.1 uc288pcf.2 
ENSMUST00000151426.3 1600025M17Rik ENSMUST00000151426.3 RIKEN cDNA 1600025M17 gene (from RefSeq NR_038168.1) ENSMUST00000151426.1 ENSMUST00000151426.2 NR_038168 uc009tga.1 uc009tga.2 uc009tga.3 uc009tga.4 uc009tga.5 uc009tga.6 uc009tga.7 uc009tga.8 uc009tga.1 uc009tga.2 uc009tga.3 uc009tga.4 uc009tga.5 uc009tga.6 uc009tga.7 uc009tga.8 
ENSMUST00000151477.8 Tnrc18 ENSMUST00000151477.8 trinucleotide repeat containing 18, transcript variant B (from RefSeq NM_178242.3) D3YV17 D3YV17_MOUSE ENSMUST00000151477.1 ENSMUST00000151477.2 ENSMUST00000151477.3 ENSMUST00000151477.4 ENSMUST00000151477.5 ENSMUST00000151477.6 ENSMUST00000151477.7 NM_178242 Tnrc18 uc009ajg.1 uc009ajg.2 uc009ajg.3 uc009ajg.1 uc009ajg.2 uc009ajg.3 
ENSMUST00000151512.2 Gm15672 ENSMUST00000151512.2 Gm15672 (from geneSymbol) AK041853 ENSMUST00000151512.1 uc291bef.1 uc291bef.2 uc291bef.1 uc291bef.2 
ENSMUST00000151524.9 Slf1 ENSMUST00000151524.9 SMC5-SMC6 complex localization factor 1 (from RefSeq NM_134071.3) Ankrd32 Brctd1 Brctx ENSMUST00000151524.1 ENSMUST00000151524.2 ENSMUST00000151524.3 ENSMUST00000151524.4 ENSMUST00000151524.5 ENSMUST00000151524.6 ENSMUST00000151524.7 ENSMUST00000151524.8 NM_134071 Q497V2 Q5XK30 Q8BHY5 Q8BQM6 Q8R3P9 Q921Y9 SLF1_MOUSE Slf1 uc007rgs.1 uc007rgs.2 uc007rgs.3 uc007rgs.4 Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions. Interacts (via BRCT domains) with RAD18 (via C-terminus and phosphorylated form); this interaction is required for efficient repair of UV-induced DNA damage (PubMed:15632077, PubMed:22036607). Interacts (via N-terminus) with SLF2; this interaction links RAD18 to the SMC5- SMC6 complex. Interacts (via BRCT domains) with RAD18; this interaction occurs in a SLF2-independent manner. Interacts with SMC6. Nucleus toplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Relocalizes with RAD18 to nuclear foci in response to DNA damage (PubMed:22036607). Colocalizes with RAD18 in the nucleus and to centrosomes (PubMed:15632077). Associates with chromatin. Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R3P9-1; Sequence=Displayed; Name=2; IsoId=Q8R3P9-2; Sequence=VSP_034415, VSP_034416; Widely expressed (PubMed:15632077). Expressed in testis (PubMed:15632077). Expressed in spermatocytes (PubMed:15632077). Expressed in the developing embryo (PubMed:15632077). BRCT domains are necessary for its targeting to ionizing radiation-induced nuclear foci (PubMed:22036607). Mice develop normally, display no pathological abnormalities and are fertile (PubMed:15632077). Sequence=AAH09101.1; Type=Erroneous initiation; Evidence=; Sequence=AAH24900.1; Type=Erroneous initiation; Evidence=; Sequence=AAH83095.1; Type=Erroneous initiation; Evidence=; nucleosome protein binding nucleus cytoplasm centrosome microtubule organizing center cytoskeleton DNA repair cellular response to DNA damage stimulus positive regulation of protein complex assembly ubiquitin protein ligase binding positive regulation of maintenance of mitotic sister chromatid cohesion site of double-strand break nuclear inclusion body macromolecular complex binding protein localization to site of double-strand break positive regulation of double-strand break repair uc007rgs.1 uc007rgs.2 uc007rgs.3 uc007rgs.4 
ENSMUST00000151528.8 Nlgn3 ENSMUST00000151528.8 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein (from UniProt A2AGI2) A2AGI2 A2AGI2_MOUSE AK039018 ENSMUST00000151528.1 ENSMUST00000151528.2 ENSMUST00000151528.3 ENSMUST00000151528.4 ENSMUST00000151528.5 ENSMUST00000151528.6 ENSMUST00000151528.7 Nlgn3 uc292prx.1 uc292prx.2 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the type-B carboxylesterase/lipase family. integral component of plasma membrane cell adhesion membrane integral component of membrane neurexin family protein binding synapse modulation of synaptic transmission synapse organization uc292prx.1 uc292prx.2 
ENSMUST00000151538.2 Macrod2os1 ENSMUST00000151538.2 Macrod2os1 (from geneSymbol) AK031201 ENSMUST00000151538.1 uc290axl.1 uc290axl.2 uc290axl.1 uc290axl.2 
ENSMUST00000151550.2 AA672651 ENSMUST00000151550.2 AA672651 (from geneSymbol) ENSMUST00000151550.1 uc292bsz.1 uc292bsz.2 uc292bsz.1 uc292bsz.2 
ENSMUST00000151575.8 Drr1 ENSMUST00000151575.8 Drr1 (from geneSymbol) AK139652 ENSMUST00000151575.1 ENSMUST00000151575.2 ENSMUST00000151575.3 ENSMUST00000151575.4 ENSMUST00000151575.5 ENSMUST00000151575.6 ENSMUST00000151575.7 uc292nij.1 uc292nij.2 uc292nij.1 uc292nij.2 
ENSMUST00000151599.2 Gm12315 ENSMUST00000151599.2 Gm12315 (from geneSymbol) ENSMUST00000151599.1 uc287zrn.1 uc287zrn.2 uc287zrn.1 uc287zrn.2 
ENSMUST00000151609.2 1700010I14Rik ENSMUST00000151609.2 RIKEN cDNA 1700010I14 gene, transcript variant 1 (from RefSeq NM_025851.3) 1700010I14Rik ENSMUST00000151609.1 NM_025851 Q3TTN6 Q3TTN6_MOUSE uc008ajx.1 uc008ajx.2 uc008ajx.3 uc008ajx.4 molecular_function cellular_component biological_process uc008ajx.1 uc008ajx.2 uc008ajx.3 uc008ajx.4 
ENSMUST00000151633.2 Rps23rg1 ENSMUST00000151633.2 Rps23rg1 (from geneSymbol) AK166699 C330021F23Rik D3Z250 D3Z250_MOUSE ENSMUST00000151633.1 Rps23rg1 uc291xtp.1 uc291xtp.2 negative regulation of protein phosphorylation adenylate cyclase binding positive regulation of protein kinase A signaling membrane integral component of membrane intrinsic component of membrane beta-amyloid metabolic process negative regulation of beta-amyloid formation uc291xtp.1 uc291xtp.2 
ENSMUST00000151639.2 Gm13839 ENSMUST00000151639.2 Gm13839 (from geneSymbol) ENSMUST00000151639.1 uc290ywu.1 uc290ywu.2 uc290ywu.1 uc290ywu.2 
ENSMUST00000151643.2 Gm12214 ENSMUST00000151643.2 Gm12214 (from geneSymbol) ENSMUST00000151643.1 uc287ydc.1 uc287ydc.2 uc287ydc.1 uc287ydc.2 
ENSMUST00000151651.2 Gm1667 ENSMUST00000151651.2 Gm1667 (from geneSymbol) ENSMUST00000151651.1 uc290rfo.1 uc290rfo.2 uc290rfo.1 uc290rfo.2 
ENSMUST00000151688.2 Ptprtos ENSMUST00000151688.2 protein tyrosine phosphatase receptor type T, opposite strand (from RefSeq NR_040617.1) ENSMUST00000151688.1 NR_040617 uc008nsa.1 uc008nsa.2 uc008nsa.3 uc008nsa.4 uc008nsa.1 uc008nsa.2 uc008nsa.3 uc008nsa.4 
ENSMUST00000151689.9 Magt1 ENSMUST00000151689.9 magnesium transporter 1, transcript variant 2 (from RefSeq NM_025952.5) ENSMUST00000151689.1 ENSMUST00000151689.2 ENSMUST00000151689.3 ENSMUST00000151689.4 ENSMUST00000151689.5 ENSMUST00000151689.6 ENSMUST00000151689.7 ENSMUST00000151689.8 Iag2 MAGT1_MOUSE Magt1 NM_025952 Q3UW45 Q9CQY5 Q9CWX5 Q9CZT3 uc009ubh.1 uc009ubh.2 uc009ubh.3 uc009ubh.4 uc009ubh.5 uc009ubh.6 Accessory component of the STT3B-containing form of the N- oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B- dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B- containing OST complex possibly involving substrate recognition. May be involved in Mg(2+) transport in epithelial cells. Protein modification; protein glycosylation. Accessory component of the STT3B-containing form of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. The association of TUSC3 or MAGT1 with the STT3B-containing complex seems to be mutually exclusvice. Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9CQY5-1; Sequence=Displayed; Name=2; IsoId=Q9CQY5-2; Sequence=VSP_019822; Name=3; IsoId=Q9CQY5-3; Sequence=VSP_019823; Expressed at high levels in kidney, colon, heart and liver. Expressed at lower levels in intestine, spleen, brain and lung. Induced by low magnesium levels. Belongs to the OST3/OST6 family. endoplasmic reticulum endoplasmic reticulum membrane plasma membrane protein glycosylation protein N-linked glycosylation oligosaccharyltransferase complex magnesium ion transmembrane transporter activity magnesium ion transport membrane integral component of membrane protein N-linked glycosylation via asparagine cognition magnesium ion transmembrane transport dolichyl-diphosphooligosaccharide-protein glycotransferase activity uc009ubh.1 uc009ubh.2 uc009ubh.3 uc009ubh.4 uc009ubh.5 uc009ubh.6 
ENSMUST00000151698.8 Laptm5 ENSMUST00000151698.8 lysosomal-associated protein transmembrane 5 (from RefSeq NM_010686.4) ENSMUST00000151698.1 ENSMUST00000151698.2 ENSMUST00000151698.3 ENSMUST00000151698.4 ENSMUST00000151698.5 ENSMUST00000151698.6 ENSMUST00000151698.7 LAPM5_MOUSE NM_010686 Q60923 Q61168 uc008uzv.1 uc008uzv.2 uc008uzv.3 May have a special functional role during embryogenesis and in adult hematopoietic cells. Binds to ubiquitin. Lysosome membrane ; Multi-pass membrane protein Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues. During embryonic development it is expressed in both hematopoietic and nonhematopoietic tissues. By retinoic acid. Likely target of the activated retinoic acid receptor alpha. Belongs to the LAPTM4/LAPTM5 transporter family. lysosome lysosomal membrane membrane integral component of membrane cellular response to leukemia inhibitory factor uc008uzv.1 uc008uzv.2 uc008uzv.3 
ENSMUST00000151703.2 Gm13173 ENSMUST00000151703.2 Gm13173 (from geneSymbol) AK135377 ENSMUST00000151703.1 uc008war.1 uc008war.2 uc008war.3 uc008war.1 uc008war.2 uc008war.3 
ENSMUST00000151765.2 B130011K05Rik ENSMUST00000151765.2 B130011K05Rik (from geneSymbol) AK044916 ENSMUST00000151765.1 uc287yyq.1 uc287yyq.2 uc287yyq.1 uc287yyq.2 
ENSMUST00000151778.2 Gm15138 ENSMUST00000151778.2 Gm15138 (from geneSymbol) ENSMUST00000151778.1 KY468262 uc292rdy.1 uc292rdy.2 uc292rdy.1 uc292rdy.2 
ENSMUST00000151782.2 A230108P19Rik ENSMUST00000151782.2 RIKEN cDNA A230108P19 gene (from RefSeq NR_040333.1) ENSMUST00000151782.1 NR_040333 uc008igj.1 uc008igj.2 uc008igj.1 uc008igj.2 
ENSMUST00000151786.8 Prkrip1 ENSMUST00000151786.8 Prkr interacting protein 1 (IL11 inducible) (from RefSeq NM_025774.3) ENSMUST00000151786.1 ENSMUST00000151786.2 ENSMUST00000151786.3 ENSMUST00000151786.4 ENSMUST00000151786.5 ENSMUST00000151786.6 ENSMUST00000151786.7 NM_025774 PKRI1_MOUSE Q8BL85 Q9CWV6 Q9CXA5 Q9CY32 uc009aaf.1 uc009aaf.2 uc009aaf.3 Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity. Component of the pre-catalytic and post-catalytic spliceosome complexes (By similarity). Interacts with EIF2AK2. Nucleus Nucleus, nucleolus Broadly expressed, with highest levels in liver, kidney, brain and heart. By IL11. Belongs to the PRKRIP1 family. Sequence=BAB31212.1; Type=Erroneous initiation; Evidence=; renal system process double-stranded RNA binding protein kinase inhibitor activity protein binding nucleus spliceosomal complex nucleolus mRNA processing negative regulation of protein kinase activity RNA splicing protein kinase binding negative regulation of phosphorylation uc009aaf.1 uc009aaf.2 uc009aaf.3 
ENSMUST00000151816.3 9930038B18Rik ENSMUST00000151816.3 9930038B18Rik (from geneSymbol) AK037014 ENSMUST00000151816.1 ENSMUST00000151816.2 uc007nae.1 uc007nae.2 uc007nae.3 uc007nae.4 uc007nae.5 uc007nae.6 uc007nae.1 uc007nae.2 uc007nae.3 uc007nae.4 uc007nae.5 uc007nae.6 
ENSMUST00000151817.3 Gm12305 ENSMUST00000151817.3 Gm12305 (from geneSymbol) ENSMUST00000151817.1 ENSMUST00000151817.2 uc287zcm.1 uc287zcm.2 uc287zcm.3 uc287zcm.1 uc287zcm.2 uc287zcm.3 
ENSMUST00000151825.4 Gm16062 ENSMUST00000151825.4 predicted gene 16062 (from RefSeq NR_045686.1) ENSMUST00000151825.1 ENSMUST00000151825.2 ENSMUST00000151825.3 NR_045686 uc007jez.1 uc007jez.2 uc007jez.3 uc007jez.4 uc007jez.5 uc007jez.6 uc007jez.7 uc007jez.8 uc007jez.1 uc007jez.2 uc007jez.3 uc007jez.4 uc007jez.5 uc007jez.6 uc007jez.7 uc007jez.8 
ENSMUST00000151826.2 Trp53rkb ENSMUST00000151826.2 transformation related protein 53 regulating kinase B (from RefSeq NM_023815.5) ENSMUST00000151826.1 NM_023815 Q543M9 Q543M9_MOUSE Trp53rkb uc008nyq.1 uc008nyq.2 uc008nyq.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. BUD32 family. protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation uc008nyq.1 uc008nyq.2 uc008nyq.3 
ENSMUST00000151841.8 9230020A06Rik ENSMUST00000151841.8 RIKEN cDNA 9230020A06 gene (from RefSeq NR_152165.1) ENSMUST00000151841.1 ENSMUST00000151841.2 ENSMUST00000151841.3 ENSMUST00000151841.4 ENSMUST00000151841.5 ENSMUST00000151841.6 ENSMUST00000151841.7 NR_152165 uc287zuy.1 uc287zuy.2 uc287zuy.1 uc287zuy.2 
ENSMUST00000151848.2 Gm13032 ENSMUST00000151848.2 predicted gene 13032 (from RefSeq NR_045944.1) ENSMUST00000151848.1 NR_045944 uc029vaf.1 uc029vaf.2 uc029vaf.1 uc029vaf.2 
ENSMUST00000151873.3 Gm16099 ENSMUST00000151873.3 Gm16099 (from geneSymbol) AK138328 ENSMUST00000151873.1 ENSMUST00000151873.2 uc287tew.1 uc287tew.2 uc287tew.3 uc287tew.1 uc287tew.2 uc287tew.3 
ENSMUST00000151884.2 4930551E15Rik ENSMUST00000151884.2 4930551E15Rik (from geneSymbol) ENSMUST00000151884.1 uc291vgu.1 uc291vgu.2 uc291vgu.1 uc291vgu.2 
ENSMUST00000151896.8 Ube4bos1 ENSMUST00000151896.8 Ube4bos1 (from geneSymbol) AK020898 ENSMUST00000151896.1 ENSMUST00000151896.2 ENSMUST00000151896.3 ENSMUST00000151896.4 ENSMUST00000151896.5 ENSMUST00000151896.6 ENSMUST00000151896.7 uc008vwf.1 uc008vwf.2 uc008vwf.1 uc008vwf.2 
ENSMUST00000151913.3 Rfx8 ENSMUST00000151913.3 regulatory factor X 8 (from RefSeq NM_001145660.1) D3YU81 ENSMUST00000151913.1 ENSMUST00000151913.2 NM_001145660 RFX8_MOUSE uc007atn.1 uc007atn.2 uc007atn.3 uc007atn.4 May be a transcription factor. Nucleus Belongs to the RFX family. RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning uc007atn.1 uc007atn.2 uc007atn.3 uc007atn.4 
ENSMUST00000151931.2 Gm13583 ENSMUST00000151931.2 Gm13583 (from geneSymbol) BC023004 ENSMUST00000151931.1 uc289wiu.1 uc289wiu.2 uc289wiu.1 uc289wiu.2 
ENSMUST00000151937.8 Slc25a12 ENSMUST00000151937.8 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 (from RefSeq NM_172436.5) A2BFG0 ENSMUST00000151937.1 ENSMUST00000151937.2 ENSMUST00000151937.3 ENSMUST00000151937.4 ENSMUST00000151937.5 ENSMUST00000151937.6 ENSMUST00000151937.7 NM_172436 Q8BH59 S2512_MOUSE Slc25a12 uc008kan.1 uc008kan.2 uc008kan.3 Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (By similarity). Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (By similarity). Reaction=H(+)(out) + L-aspartate(in) + L-glutamate(out) = H(+)(in) + L- aspartate(out) + L-glutamate(in); Xref=Rhea:RHEA:70783, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:29991; Evidence=; Reaction=3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) = 3- sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out); Xref=Rhea:RHEA:70967, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:61085; Evidence=; Reaction=3-sulfino-L-alanine(out) + L-aspartate(in) = 3-sulfino-L- alanine(in) + L-aspartate(out); Xref=Rhea:RHEA:70975, ChEBI:CHEBI:29991, ChEBI:CHEBI:61085; Evidence=; Homodimer (via N-terminus). Mitochondrion inner membrane ; Multi-pass membrane protein The EF-hand 2 domain within the regulatory N-terminal domain binds one calcium in the mitochondrial intermembrane space. Calcium triggers the binding of the regulatory N-terminal domain to the C- terminal domain, opening a vestibule which allows the substrates to be translocated through the carrier domain. In the absence of calcium, the linker loop domain may close the vestibule and prevent substrates from entering the carrier domain. Belongs to the mitochondrial carrier (TC 2.A.29) family. L-glutamate transmembrane transporter activity calcium ion binding mitochondrion mitochondrial inner membrane glutamate biosynthetic process positive regulation of glucose metabolic process L-aspartate transmembrane transporter activity aspartate transport L-glutamate transport membrane integral component of membrane transmembrane transporter activity positive regulation of myelination identical protein binding myelin sheath malate-aspartate shuttle metal ion binding response to calcium ion transmembrane transport L-aspartate transport negative regulation of glucose catabolic process to lactate via pyruvate positive regulation of ATP biosynthetic process uc008kan.1 uc008kan.2 uc008kan.3 
ENSMUST00000151952.8 Mgat4a ENSMUST00000151952.8 mannoside acetylglucosaminyltransferase 4, isoenzyme A, transcript variant 1 (from RefSeq NM_173870.3) ENSMUST00000151952.1 ENSMUST00000151952.2 ENSMUST00000151952.3 ENSMUST00000151952.4 ENSMUST00000151952.5 ENSMUST00000151952.6 ENSMUST00000151952.7 MGT4A_MOUSE Mgat4a NM_173870 Q3TQT1 Q80UI0 Q812G0 uc007arv.1 uc007arv.2 uc007arv.3 uc007arv.4 Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (PubMed:16377570). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (PubMed:16377570). Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc- (1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D- glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc- (1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]- beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl- [protein] + UDP; Xref=Rhea:RHEA:16057, Rhea:RHEA-COMP:13526, Rhea:RHEA-COMP:14374, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:60651, ChEBI:CHEBI:139507; EC=2.4.1.145; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16058; Evidence=; Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- (1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L- asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)- [alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D- GlcNAc}-L-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:69615, Rhea:RHEA-COMP:14369, Rhea:RHEA-COMP:17732, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:60615, ChEBI:CHEBI:187873; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69616; Evidence=; Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc- (1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N- acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta- D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D- GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc- (1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:69619, Rhea:RHEA-COMP:17733, Rhea:RHEA-COMP:17734, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:187874, ChEBI:CHEBI:187875; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69620; Evidence=; Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc- (1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- [alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N- acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta- D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D- Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc- (1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:69623, Rhea:RHEA-COMP:13532, Rhea:RHEA-COMP:18198, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:137207, ChEBI:CHEBI:187877; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69624; Evidence=; Reaction=N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man- (1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N- acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D- GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D- GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc- (1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:69627, Rhea:RHEA-COMP:17737, Rhea:RHEA-COMP:17738, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:187878, ChEBI:CHEBI:187879; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69628; Evidence=; Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- (1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N- acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta- D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man- (1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc}-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:69631, Rhea:RHEA-COMP:17739, Rhea:RHEA-COMP:17740, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:187880, ChEBI:CHEBI:187881; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69632; Evidence=; Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man- (1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)- [beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D- GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:69635, Rhea:RHEA-COMP:17741, Rhea:RHEA-COMP:17742, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:187882, ChEBI:CHEBI:187883; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69636; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Inhibited by UDP. Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein [Alpha-1,3-mannosyl-glycoprotein 4-beta-N- acetylglucosaminyltransferase A soluble form]: Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q812G0-1; Sequence=Displayed; Name=2; IsoId=Q812G0-2; Sequence=VSP_025715; N-glycosylated. Mice display impaired beta cell glucose transport and insulin secretion causing type 2 diabete. This is due to defects in SLC2A2/Glut-2 glycosylation, provoking SLC2A2/Glut-2 endocytosis with redistribution into endosomes and lysosomes. Belongs to the glycosyltransferase 54 family. Golgi membrane extracellular region endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus Golgi stack protein glycosylation protein N-linked glycosylation acetylglucosaminyltransferase activity alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups metal ion binding uc007arv.1 uc007arv.2 uc007arv.3 uc007arv.4 
ENSMUST00000151967.3 Gm15969 ENSMUST00000151967.3 Gm15969 (from geneSymbol) ENSMUST00000151967.1 ENSMUST00000151967.2 uc290rwp.1 uc290rwp.2 uc290rwp.3 uc290rwp.1 uc290rwp.2 uc290rwp.3 
ENSMUST00000151979.8 E330012B07Rik ENSMUST00000151979.8 RIKEN cDNA E330012B07 gene (from RefSeq NR_033640.1) ENSMUST00000151979.1 ENSMUST00000151979.2 ENSMUST00000151979.3 ENSMUST00000151979.4 ENSMUST00000151979.5 ENSMUST00000151979.6 ENSMUST00000151979.7 NR_033640 uc009esv.1 uc009esv.2 uc009esv.3 uc009esv.4 uc009esv.1 uc009esv.2 uc009esv.3 uc009esv.4 
ENSMUST00000151984.8 Gm13571 ENSMUST00000151984.8 predicted gene 13571, transcript variant 1 (from RefSeq NR_190169.1) ENSMUST00000151984.1 ENSMUST00000151984.2 ENSMUST00000151984.3 ENSMUST00000151984.4 ENSMUST00000151984.5 ENSMUST00000151984.6 ENSMUST00000151984.7 NR_190169 uc008juf.1 uc008juf.2 uc008juf.1 uc008juf.2 
ENSMUST00000151994.8 Gm13179 ENSMUST00000151994.8 Gm13179 (from geneSymbol) AK027935 ENSMUST00000151994.1 ENSMUST00000151994.2 ENSMUST00000151994.3 ENSMUST00000151994.4 ENSMUST00000151994.5 ENSMUST00000151994.6 ENSMUST00000151994.7 uc008iew.1 uc008iew.2 uc008iew.1 uc008iew.2 
ENSMUST00000151998.2 Notumos ENSMUST00000151998.2 Notumos (from geneSymbol) AK028718 ENSMUST00000151998.1 uc288ehy.1 uc288ehy.2 uc288ehy.1 uc288ehy.2 
ENSMUST00000152002.4 Uchl1os ENSMUST00000152002.4 ubiquitin carboxy-terminal hydrolase L1, opposite strand (from RefSeq NR_102714.1) ENSMUST00000152002.1 ENSMUST00000152002.2 ENSMUST00000152002.3 NR_102714 uc008xpe.1 uc008xpe.2 uc008xpe.3 uc008xpe.1 uc008xpe.2 uc008xpe.3 
ENSMUST00000152070.3 Gm15640 ENSMUST00000152070.3 Gm15640 (from geneSymbol) ENSMUST00000152070.1 ENSMUST00000152070.2 uc289exb.1 uc289exb.2 uc289exb.3 uc289exb.1 uc289exb.2 uc289exb.3 
ENSMUST00000152079.2 Gm14929 ENSMUST00000152079.2 Gm14929 (from geneSymbol) AK139886 ENSMUST00000152079.1 uc292qgy.1 uc292qgy.2 uc292qgy.1 uc292qgy.2 
ENSMUST00000152080.8 Slc35e1 ENSMUST00000152080.8 solute carrier family 35, member E1 (from RefSeq NM_177766.3) ENSMUST00000152080.1 ENSMUST00000152080.2 ENSMUST00000152080.3 ENSMUST00000152080.4 ENSMUST00000152080.5 ENSMUST00000152080.6 ENSMUST00000152080.7 NM_177766 Q8CD26 S35E1_MOUSE uc009mge.1 uc009mge.2 uc009mge.3 uc009mge.4 Putative transporter. Membrane ; Multi-pass membrane protein Belongs to the TPT transporter family. SLC35E subfamily. Sequence=BAC27470.1; Type=Erroneous initiation; Evidence=; Golgi apparatus antiporter activity membrane integral component of membrane transmembrane transporter activity transmembrane transport uc009mge.1 uc009mge.2 uc009mge.3 uc009mge.4 
ENSMUST00000152086.2 Gm12753 ENSMUST00000152086.2 Gm12753 (from geneSymbol) ENSMUST00000152086.1 uc290lri.1 uc290lri.2 uc290lri.1 uc290lri.2 
ENSMUST00000152112.3 Gm14275 ENSMUST00000152112.3 Gm14275 (from geneSymbol) AK146124 ENSMUST00000152112.1 ENSMUST00000152112.2 uc290cxi.1 uc290cxi.2 uc290cxi.3 uc290cxi.1 uc290cxi.2 uc290cxi.3 
ENSMUST00000152116.3 Gm15866 ENSMUST00000152116.3 Gm15866 (from geneSymbol) AK079714 ENSMUST00000152116.1 ENSMUST00000152116.2 uc008xhm.1 uc008xhm.2 uc008xhm.3 uc008xhm.1 uc008xhm.2 uc008xhm.3 
ENSMUST00000152147.8 Stmp1 ENSMUST00000152147.8 short transmembrane mitochondrial protein 1, transcript variant 2 (from RefSeq NM_001384235.1) A0A5F8MPG2 ENSMUST00000152147.1 ENSMUST00000152147.2 ENSMUST00000152147.3 ENSMUST00000152147.4 ENSMUST00000152147.5 ENSMUST00000152147.6 ENSMUST00000152147.7 Mtlbn NM_001384235 P0DP99 Q3TAI1 STMP1_MOUSE Stmp1 uc009bin.1 uc009bin.2 uc009bin.3 uc009bin.4 Microprotein involved in mitochondrial respiratory chain complex III (ubiquinol-cytochrome c oxidoreductase) and complex IV (mitochondrial cytochrome c oxidase complex) assembly (PubMed:35101990). Required for the formation of mitochondrial supercomplexes (SCs) (PubMed:35101990). Also required for the activation of the NLRP3 inflammasome (PubMed:31836654). Interacts with components of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), such as UQCRC1/QCR1, UQCRC2/QCR2 and UQCR10/QCR9 (PubMed:35101990). Interacts with components of the cytochrome c oxidase (mitochondrial respiratory chain complex IV) complex, such as MT-CO2 (By similarity). Mitochondrion inner membrane ; Single-pass membrane protein Mitochondrion outer membrane ; Single-pass membrane protein Mitochondrion intermembrane space Widely expressed, with highest levels in lung, skeletal muscle and heart (PubMed:31836654, PubMed:35101990). Expressed in bone marrow-derived macrophages (at protein level) (PubMed:31836654). Down-regulated by TLR ligands, including bacterial lipopolysaccharide (LPS), in bone marrow-derived macrophages. Mice were born at expected Mendelian ratios and do not show any visible phenotype, displaying normal heart function and cardiac dimensions (PubMed:35101990). Cells however display defects in complex III activity and metabolic perturbations in the heart, as well as altered complex III assembly into respiratory supercomplexes (PubMed:35101990). Belongs to the STMP1 family. Sequence=BAE42687.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; mitochondrion mitochondrial respiratory chain membrane integral component of membrane mitochondrial membrane uc009bin.1 uc009bin.2 uc009bin.3 uc009bin.4 
ENSMUST00000152171.8 Smim5 ENSMUST00000152171.8 small integral membrane protein 5 (from RefSeq NM_183259.3) ENSMUST00000152171.1 ENSMUST00000152171.2 ENSMUST00000152171.3 ENSMUST00000152171.4 ENSMUST00000152171.5 ENSMUST00000152171.6 ENSMUST00000152171.7 NM_183259 Q8BT42 SMIM5_MOUSE uc007mja.1 uc007mja.2 uc007mja.3 uc007mja.4 Membrane ; Single-pass membrane protein molecular_function biological_process membrane integral component of membrane uc007mja.1 uc007mja.2 uc007mja.3 uc007mja.4 
ENSMUST00000152172.2 Gm11636 ENSMUST00000152172.2 Gm11636 (from geneSymbol) ENSMUST00000152172.1 uc288cqw.1 uc288cqw.2 uc288cqw.1 uc288cqw.2 
ENSMUST00000152192.2 Sox5os5 ENSMUST00000152192.2 Sox5os5 (from geneSymbol) ENSMUST00000152192.1 uc291kdf.1 uc291kdf.2 uc291kdf.1 uc291kdf.2 
ENSMUST00000152203.8 Arhgap20os ENSMUST00000152203.8 Arhgap20os (from geneSymbol) AK135715 ENSMUST00000152203.1 ENSMUST00000152203.2 ENSMUST00000152203.3 ENSMUST00000152203.4 ENSMUST00000152203.5 ENSMUST00000152203.6 ENSMUST00000152203.7 uc009plk.1 uc009plk.2 uc009plk.1 uc009plk.2 
ENSMUST00000152208.8 Tnni1 ENSMUST00000152208.8 troponin I, skeletal, slow 1, transcript variant 1 (from RefSeq NM_021467.5) ENSMUST00000152208.1 ENSMUST00000152208.2 ENSMUST00000152208.3 ENSMUST00000152208.4 ENSMUST00000152208.5 ENSMUST00000152208.6 ENSMUST00000152208.7 NM_021467 Q9WUZ5 TNNI1_MOUSE uc033flq.1 uc033flq.2 uc033flq.3 uc033flq.4 Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Belongs to the troponin I family. skeletal muscle contraction actin binding troponin complex muscle contraction regulation of muscle contraction transition between fast and slow fiber metal ion binding ventricular cardiac muscle tissue morphogenesis cardiac muscle contraction uc033flq.1 uc033flq.2 uc033flq.3 uc033flq.4 
ENSMUST00000152227.8 Desi1 ENSMUST00000152227.8 desumoylating isopeptidase 1, transcript variant 4 (from RefSeq NR_177967.1) D15Wsu75e DESI1_MOUSE Desi1 ENSMUST00000152227.1 ENSMUST00000152227.2 ENSMUST00000152227.3 ENSMUST00000152227.4 ENSMUST00000152227.5 ENSMUST00000152227.6 ENSMUST00000152227.7 Fam152b NR_177967 Pppde2 Q3V2M9 Q9CQT7 uc007wxw.1 uc007wxw.2 uc007wxw.3 Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins (PubMed:22370726, PubMed:22498933). Has isopeptidase but not SUMO-processing activity (PubMed:22370726, PubMed:22498933). Desumoylates ZBTB46 (PubMed:22370726). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (By similarity). Homodimer (PubMed:22370726, PubMed:22498933). Interacts with UBQLN4; leading to the export of UBQLN4 from the nucleus (By similarity). Q9CQT7; Q9CQT7: Desi1; NbExp=3; IntAct=EBI-7768710, EBI-7768710; Q9CQT7; Q8BID6: Zbtb46; NbExp=2; IntAct=EBI-7768710, EBI-7768990; Cytoplasm Nucleus Note=Shuttles between the nucleus and the cytoplasm; exported from the nucleus in a XPO1/CRM1-dependent manner via its nuclear export signal motifs. Belongs to the DeSI family. protein binding cellular_component nucleus cytoplasm proteolysis biological_process peptidase activity hydrolase activity identical protein binding uc007wxw.1 uc007wxw.2 uc007wxw.3 
ENSMUST00000152229.2 Rspo4os ENSMUST00000152229.2 Rspo4os (from geneSymbol) AK080248 ENSMUST00000152229.1 uc290bje.1 uc290bje.2 uc290bje.1 uc290bje.2 
ENSMUST00000152230.3 Gm13816 ENSMUST00000152230.3 Gm13816 (from geneSymbol) ENSMUST00000152230.1 ENSMUST00000152230.2 KY467878 uc057ldq.1 uc057ldq.2 uc057ldq.3 uc057ldq.1 uc057ldq.2 uc057ldq.3 
ENSMUST00000152233.9 Ankzf1 ENSMUST00000152233.9 ankyrin repeat and zinc finger domain containing 1, transcript variant 18 (from RefSeq NR_175888.1) Ankzf1 ENSMUST00000152233.1 ENSMUST00000152233.2 ENSMUST00000152233.3 ENSMUST00000152233.4 ENSMUST00000152233.5 ENSMUST00000152233.6 ENSMUST00000152233.7 ENSMUST00000152233.8 J3QM81 J3QM81_MOUSE NR_175888 uc029qpe.1 uc029qpe.2 uc029qpe.3 uc029qpe.4 Cytoplasm Belongs to the ANKZF1/VMS1 family. nucleic acid binding cytoplasm cellular response to hydrogen peroxide uc029qpe.1 uc029qpe.2 uc029qpe.3 uc029qpe.4 
ENSMUST00000152250.2 Gm14211 ENSMUST00000152250.2 Gm14211 (from geneSymbol) ENSMUST00000152250.1 uc290aul.1 uc290aul.2 uc290aul.1 uc290aul.2 
ENSMUST00000152262.2 Gm4750 ENSMUST00000152262.2 predicted gene 4750 (from RefSeq NR_152261.1) ENSMUST00000152262.1 NR_152261 uc292rgx.1 uc292rgx.2 uc292rgx.1 uc292rgx.2 
ENSMUST00000152302.2 Gm15677 ENSMUST00000152302.2 Gm15677 (from geneSymbol) AK042514 ENSMUST00000152302.1 uc009kbw.1 uc009kbw.2 uc009kbw.1 uc009kbw.2 
ENSMUST00000152306.2 Gm11924 ENSMUST00000152306.2 Gm11924 (from geneSymbol) AK076999 ENSMUST00000152306.1 uc290lon.1 uc290lon.2 uc290lon.1 uc290lon.2 
ENSMUST00000152342.3 Gm44641 ENSMUST00000152342.3 Gm44641 (from geneSymbol) AK079366 ENSMUST00000152342.1 ENSMUST00000152342.2 uc291nes.1 uc291nes.2 uc291nes.1 uc291nes.2 
ENSMUST00000152343.8 Tex16 ENSMUST00000152343.8 testis expressed gene 16, transcript variant 4 (from RefSeq NM_001177389.1) 4933403O08Rik ENSMUST00000152343.1 ENSMUST00000152343.2 ENSMUST00000152343.3 ENSMUST00000152343.4 ENSMUST00000152343.5 ENSMUST00000152343.6 ENSMUST00000152343.7 F6RC93 F6UK53 F6UK53_MOUSE NM_001177389 Tex16 uc009ude.1 uc009ude.2 molecular_function cellular_component biological_process uc009ude.1 uc009ude.2 
ENSMUST00000152351.2 Fhad1os2 ENSMUST00000152351.2 Fhad1os2 (from geneSymbol) AK046315 ENSMUST00000152351.1 uc290rkt.1 uc290rkt.2 uc290rkt.1 uc290rkt.2 
ENSMUST00000152352.3 4930515L19Rik ENSMUST00000152352.3 RIKEN cDNA 4930515L19 gene (from RefSeq NR_045440.1) ENSMUST00000152352.1 ENSMUST00000152352.2 NR_045440 uc029xjs.1 uc029xjs.2 uc029xjs.3 uc029xjs.1 uc029xjs.2 uc029xjs.3 
ENSMUST00000152384.3 Foxo6os ENSMUST00000152384.3 forkhead box O6, opposite strand (from RefSeq NR_166471.1) ENSMUST00000152384.1 ENSMUST00000152384.2 NR_166471 uc290pmg.1 uc290pmg.2 uc290pmg.3 uc290pmg.1 uc290pmg.2 uc290pmg.3 
ENSMUST00000152420.8 Osgin1 ENSMUST00000152420.8 oxidative stress induced growth inhibitor 1, transcript variant 1 (from RefSeq NM_027950.2) ENSMUST00000152420.1 ENSMUST00000152420.2 ENSMUST00000152420.3 ENSMUST00000152420.4 ENSMUST00000152420.5 ENSMUST00000152420.6 ENSMUST00000152420.7 NM_027950 OSGI1_MOUSE Osgin1 Q8VC10 uc009npp.1 uc009npp.2 uc009npp.3 Regulates the differentiation and proliferation through the regulation of cell death. Belongs to the OKL38 family. cellular_component signal transduction growth factor activity cell differentiation negative regulation of cell growth regulation of cell migration regulation of growth regulation of cell proliferation regulation of apoptotic process positive regulation of apoptotic process uc009npp.1 uc009npp.2 uc009npp.3 
ENSMUST00000152459.8 Cadm1 ENSMUST00000152459.8 cell adhesion molecule 1, transcript variant 5 (from RefSeq NM_001310841.1) Cadm1 E9PYN1 E9PYN1_MOUSE ENSMUST00000152459.1 ENSMUST00000152459.2 ENSMUST00000152459.3 ENSMUST00000152459.4 ENSMUST00000152459.5 ENSMUST00000152459.6 ENSMUST00000152459.7 NM_001310841 uc012gso.1 uc012gso.2 uc012gso.3 uc012gso.4 uc012gso.5 Belongs to the nectin family. receptor binding plasma membrane cell recognition membrane integral component of membrane susceptibility to natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity positive regulation of cytokine secretion detection of stimulus uc012gso.1 uc012gso.2 uc012gso.3 uc012gso.4 uc012gso.5 
ENSMUST00000152467.3 1700057H21Rik ENSMUST00000152467.3 1700057H21Rik (from geneSymbol) AK006824 ENSMUST00000152467.1 ENSMUST00000152467.2 uc289wbq.1 uc289wbq.2 uc289wbq.3 uc289wbq.1 uc289wbq.2 uc289wbq.3 
ENSMUST00000152483.3 4932414J04Rik ENSMUST00000152483.3 RIKEN cDNA 4932414J04 gene (from RefSeq NR_028259.1) ENSMUST00000152483.1 ENSMUST00000152483.2 NR_028259 uc011xsa.1 uc011xsa.2 uc011xsa.3 uc011xsa.4 uc011xsa.1 uc011xsa.2 uc011xsa.3 uc011xsa.4 
ENSMUST00000152538.2 Plxna4os2 ENSMUST00000152538.2 Plxna4os2 (from geneSymbol) AK034724 ENSMUST00000152538.1 uc291dje.1 uc291dje.2 uc291dje.1 uc291dje.2 
ENSMUST00000152542.2 A530006G24Rik ENSMUST00000152542.2 RIKEN cDNA A530006G24 gene (from RefSeq NR_046014.1) ENSMUST00000152542.1 NR_046014 uc008msz.1 uc008msz.2 uc008msz.1 uc008msz.2 
ENSMUST00000152569.2 Gm13684 ENSMUST00000152569.2 Gm13684 (from geneSymbol) AK030373 ENSMUST00000152569.1 uc289xjo.1 uc289xjo.2 uc289xjo.1 uc289xjo.2 
ENSMUST00000152576.2 Gm11944 ENSMUST00000152576.2 predicted gene 11944 (from RefSeq NR_045708.1) ENSMUST00000152576.1 NR_045708 uc029rkd.1 uc029rkd.2 uc029rkd.3 uc029rkd.1 uc029rkd.2 uc029rkd.3 
ENSMUST00000152594.8 Zbtb38 ENSMUST00000152594.8 Nucleus (from UniProt Q3LR78) AK044467 ENSMUST00000152594.1 ENSMUST00000152594.2 ENSMUST00000152594.3 ENSMUST00000152594.4 ENSMUST00000152594.5 ENSMUST00000152594.6 ENSMUST00000152594.7 Q3LR78 Q3LR78_MOUSE Zbtb38 uc009rcs.1 uc009rcs.2 uc009rcs.3 uc009rcs.4 Nucleus nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of DNA replication regulation of transcription, DNA-templated cellular response to DNA damage stimulus methyl-CpG binding protein homodimerization activity negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc009rcs.1 uc009rcs.2 uc009rcs.3 uc009rcs.4 
ENSMUST00000152600.2 Gm15344 ENSMUST00000152600.2 Gm15344 (from geneSymbol) ENSMUST00000152600.1 uc287tut.1 uc287tut.2 uc287tut.1 uc287tut.2 
ENSMUST00000152625.2 Nphs1os ENSMUST00000152625.2 nephrosis 1 homolog, nephrin, opposite strand (from RefSeq NR_004443.2) ENSMUST00000152625.1 NR_004443 uc012fhq.1 uc012fhq.2 uc012fhq.1 uc012fhq.2 
ENSMUST00000152648.2 Gm15063 ENSMUST00000152648.2 predicted gene 15063 (from RefSeq NR_189047.1) ENSMUST00000152648.1 NR_189047 uc009tqf.1 uc009tqf.2 uc009tqf.1 uc009tqf.2 
ENSMUST00000152669.2 Gm14661 ENSMUST00000152669.2 Gm14661 (from geneSymbol) AY512909 ENSMUST00000152669.1 uc292oja.1 uc292oja.2 uc292oja.1 uc292oja.2 
ENSMUST00000152703.2 Tnfrsf23 ENSMUST00000152703.2 tumor necrosis factor receptor superfamily, member 23, transcript variant 1 (from RefSeq NM_024290.4) Dctrailr1 ENSMUST00000152703.1 NM_024290 Q8VHC0 Q9ER63 TNR23_MOUSE Tnfrh1 Tnfrsf1al1 uc009kpu.1 uc009kpu.2 uc009kpu.3 uc009kpu.4 This gene encodes a member of the tumor necrosis factor superfamily of proteins. The encoded receptor has been shown to bind to the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), but to have no signaling capacity. This gene shows elevated expression in mice with diet-induced fatty liver disease. This gene and other family members are present in a gene cluster on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis through ligand competition. Cannot induce the NF-kappa-B pathway. Cell membrane ; Lipid-anchor, GPI-anchor Ubiquitous. protein binding plasma membrane membrane anchored component of membrane anchored component of external side of plasma membrane negative regulation of extrinsic apoptotic signaling pathway via death domain receptors uc009kpu.1 uc009kpu.2 uc009kpu.3 uc009kpu.4 
ENSMUST00000152704.8 Btf3 ENSMUST00000152704.8 basic transcription factor 3, transcript variant 2 (from RefSeq NM_001170540.1) BTF3_MOUSE ENSMUST00000152704.1 ENSMUST00000152704.2 ENSMUST00000152704.3 ENSMUST00000152704.4 ENSMUST00000152704.5 ENSMUST00000152704.6 ENSMUST00000152704.7 NM_001170540 Q64152 Q64153 Q6GU63 Q6P3F3 uc007rov.1 uc007rov.2 uc007rov.3 When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription (By similarity). Part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of NACA and BTF3 (via NAC-A/B domains). NAC associates with ribosomes through the BTF3/NACB subunit. Both subunits can contact nascent polypeptide chains (By similarity). Cytoplasm Nucleus. Note=The heterodimer with NACA is cytoplasmic. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=BTF3a; IsoId=Q64152-1; Sequence=Displayed; Name=2; Synonyms=BTF3b; IsoId=Q64152-2; Sequence=VSP_013588; Belongs to the NAC-beta family. in utero embryonic development nucleus cytoplasm cytosol nascent polypeptide-associated complex protein transport polysomal ribosome uc007rov.1 uc007rov.2 uc007rov.3 
ENSMUST00000152709.2 A130023I24Rik ENSMUST00000152709.2 A130023I24Rik (from geneSymbol) AK037526 ENSMUST00000152709.1 uc291wmy.1 uc291wmy.2 uc291wmy.1 uc291wmy.2 
ENSMUST00000152730.4 Rhox13 ENSMUST00000152730.4 reproductive homeobox 13 (from RefSeq NM_001185002.2) ENSMUST00000152730.1 ENSMUST00000152730.2 ENSMUST00000152730.3 F6YCR7 NM_001185002 Q8C1Q7 RHX13_MOUSE Rhox13 uc009szo.1 uc009szo.2 uc009szo.3 uc009szo.4 Probable transcription factor. Nucleus In adult testis, expressed in differentiating spermatagonia and preleptotene spermatocytes, but not during other stages of spermatogenesis (at protein level). Detected in testis from 13.5 days post coitum (dpc) onwards. Detected in ovary from 13.5 dpc, but levels gradually decline and are undetectable by 3 days post partum (dpp). Belongs to the paired-like homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding cellular response to retinoic acid uc009szo.1 uc009szo.2 uc009szo.3 uc009szo.4 
ENSMUST00000152758.4 Or5aq1 ENSMUST00000152758.4 olfactory receptor family 5 subfamily AQ member 1 (from RefSeq NM_146769.2) ENSMUST00000152758.1 ENSMUST00000152758.2 ENSMUST00000152758.3 NM_146769 Olfr1110 Or5aq1 Q8VG38 Q8VG38_MOUSE uc289xub.1 uc289xub.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: CB172930.1, CB173030.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xub.1 uc289xub.2 
ENSMUST00000152781.3 C78197 ENSMUST00000152781.3 expressed sequence C78197 (from RefSeq NR_189021.1) ENSMUST00000152781.1 ENSMUST00000152781.2 NR_189021 uc007jnl.1 uc007jnl.2 uc007jnl.1 uc007jnl.2 
ENSMUST00000152787.3 Usp46os2 ENSMUST00000152787.3 Usp46os2 (from geneSymbol) AK016772 ENSMUST00000152787.1 ENSMUST00000152787.2 uc290wjt.1 uc290wjt.2 uc290wjt.1 uc290wjt.2 
ENSMUST00000152793.2 Gm14707 ENSMUST00000152793.2 Gm14707 (from geneSymbol) ENSMUST00000152793.1 uc292pds.1 uc292pds.2 uc292pds.1 uc292pds.2 
ENSMUST00000152796.8 Ythdf2 ENSMUST00000152796.8 YTH N6-methyladenosine RNA binding protein 2 (from RefSeq NM_145393.4) ENSMUST00000152796.1 ENSMUST00000152796.2 ENSMUST00000152796.3 ENSMUST00000152796.4 ENSMUST00000152796.5 ENSMUST00000152796.6 ENSMUST00000152796.7 NM_145393 Q3TWU3 Q8BM70 Q8K325 Q91YT7 YTHD2_MOUSE Ythdf2 uc008vas.1 uc008vas.2 uc008vas.3 uc008vas.4 Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, and regulates their stability (PubMed:28867294, PubMed:29855337, PubMed:32943573). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:28867294, PubMed:29855337, PubMed:32943573). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context (PubMed:29855337, PubMed:30065315, PubMed:32943573, PubMed:32905781). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:32943573). M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex (By similarity). Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs (PubMed:32905781). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (PubMed:28867294). Also required during spermatogenesis: regulates spermagonial adhesion by promoting degradation of m6A-containing transcripts coding for matrix metallopeptidases (PubMed:31959747). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation (PubMed:30065315, PubMed:30150673). Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets (PubMed:29855337). Inhibits neural specification of induced pluripotent stem cells by binding to methylated neural-specific mRNAs and promoting their degradation, thereby restraining neural differentiation (By similarity). Regulates circadian regulation of hepatic lipid metabolism: acts by promoting m6A-dependent degradation of PPARA transcripts (By similarity). Regulates the innate immune response to infection by inhibiting the type I interferon response: acts by binding to m6A-containing IFNB transcripts and promoting their degradation (PubMed:30559377). May also act as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (By similarity). Regulates mitotic entry by promoting the phase-specific m6A-dependent degradation of WEE1 transcripts (By similarity). Promotes formation of phase- separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (By similarity). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (By similarity). May also recognize and bind RNAs modified by C5-methylcytosine (m5C) and act as a regulator of rRNA processing (By similarity). Interacts with CNOT1; interaction is direct and promotes recruitment of the CCR4-NOT complex (PubMed:32905781). Interacts with YTHDF3 (By similarity). Interacts with RIDA/HRSP12; interaction leads to recruitment of the ribonuclease P/MRP complex (By similarity). Cytoplasm, cytosol toplasm, P-body Cytoplasm, Stress granule Nucleus Note=Localizes to the cytosol and relocates to the nucleus following heat shock stress. Can partition into different structures: into P- bodies in unstressed cells, and into stress granules during stress. Widely expressed, with highest expression in testis. Expressed in the germline during gametogenesis: expressed at all stages of spermatogenesis, with elevated expression observed in pachytene spermatocytes (PubMed:28867294). During oogenesis, expressed at all stages of folliculogenesis: expressed both in the oocyte and in somatic granulosa cells (PubMed:28867294). Also expressed during oocyte maturation, with abundant expression in germinal vesicle as well as in meiosis II oocytes (PubMed:28867294). The disordered regions have the ability to interact with each other and to 'phase separate' into liquid droplets within the cytosol following binding to mRNAs containing multiple m6A-modified residues. This leads to the partition of m6A-containing mRNAs into membraneless compartments, where mRNAs may be stored, degraded or used to transport mRNAs to dendritic arbors in neurons. Ubiquitinated by the SCF(SKP2) complex, leading to its degradation. Female are infertile despite successful ovulation (PubMed:28867294, PubMed:32943573). Corpora lutea is present in ovaries, indicating that ovulation has occurred (PubMed:28867294). Defects during oocyte maturation are probably caused by the deregulation of some transcripts, leading to an arrest prior to or at the two-cell stage, with various cytokinesis defects observed in the two-cell embryos (PubMed:28867294). Males are hypofertile because of mild degenerative changes in the seminiferous tubules, including large scattered vacuoles in Sertoli cells and severe loss of sperm in the cauda epididymis (PubMed:32943573). Conditional deletion in embryos leads to lethality at late embryonic developmental stages, caused by defects in neural development (PubMed:29855337). Conditional deletion in spermatogonia leads to impaired spermatogonial proliferation caused by decreased cell spread (PubMed:31959747). The proliferation and differentiation capabilities of neural stem/progenitor cell (NSPC) decrease significantly in conditional deletion mutant embryos (PubMed:29855337). Conditional deletion in hematopoietic stem cells promotes hematopoietic stem cell expansion (PubMed:30065315, PubMed:30150673). Mice lacking Ythdf1, Ythdf2 and Ythdf3 display early embryonic lethality and show defects in embryonic stem cell differentiation (PubMed:32943573). Belongs to the YTHDF family. YTHDF2 subfamily. Previous studies suggested the 3 different paralogs (YTHDF1, YTHDF2 and YTHDF3) have unique functions with limited redundancy (By similarity). However, later studies showed that YTHDF1, YTHDF2 and YTHDF3 paralogs have redundant functions to a profound extent and directly promote degradation of m6A-containing mRNAs (PubMed:32943573). P-body oocyte maturation immune system process RNA binding nucleus cytoplasm microtubule organizing center cytosol mRNA catabolic process cell differentiation cytoplasmic ribonucleoprotein granule regulation of mRNA stability innate immune response negative regulation of Notch signaling pathway oogenesis embryonic morphogenesis regulation of neurogenesis negative regulation of type I interferon-mediated signaling pathway mRNA destabilization hematopoietic stem cell proliferation endothelial to hematopoietic transition regulation of hematopoietic stem cell differentiation regulation of meiotic cell cycle process involved in oocyte maturation positive regulation of cap-independent translational initiation N6-methyladenosine-containing RNA binding uc008vas.1 uc008vas.2 uc008vas.3 uc008vas.4 
ENSMUST00000152849.2 Gm12081 ENSMUST00000152849.2 Gm12081 (from geneSymbol) ENSMUST00000152849.1 uc287xcn.1 uc287xcn.2 uc287xcn.1 uc287xcn.2 
ENSMUST00000152855.3 Nhej1 ENSMUST00000152855.3 non-homologous end joining factor 1 (from RefSeq NM_029342.4) A2RT39 ENSMUST00000152855.1 ENSMUST00000152855.2 NHEJ1_MOUSE NM_029342 Nhej1 Q3KNJ2 Q99JK0 Q9D9U0 Xlf uc287jhf.1 uc287jhf.2 DNA repair protein involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination (PubMed:17360556, PubMed:27601299, PubMed:27798842, PubMed:27601633, PubMed:27830975, PubMed:28051062, PubMed:29077092, PubMed:30017584). Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends (PubMed:17360556). Interacts with POLL (DNA polymerase lambda); promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL (By similarity). May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary (PubMed:17360556). Associates with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (By similarity). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (By similarity). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (By similarity). Binds DNA in a length-dependent manner (By similarity). Homodimer; mainly exists as a homodimer when not associated with XRCC4. Interacts with XRCC4; the interaction is direct and is mediated via a head-to-head interaction between N-terminal head regions. Component of the core long-range non-homologous end joining (NHEJ) complex (also named DNA-PK complex) composed of PRKDC, LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF. Additional component of the NHEJ complex includes PAXX. Following autophosphorylation, PRKDC dissociates from DNA, leading to formation of the short-range NHEJ complex, composed of LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF. Interacts with POLL (DNA polymerase lambda); promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL. Nucleus Chromosome Note=Localizes to site of double-strand breaks; recruitment is dependent on XRCC5-XRCC6 (Ku) heterodimer. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3KNJ2-1; Sequence=Displayed; Name=2; IsoId=Q3KNJ2-2; Sequence=VSP_017690; The coiled-coil region mediates homodimerization. The Leu-lock (Leu-115) site inserts into a hydrophobic pocket in XRCC4. Phosphorylated by PRKDC at the C-terminus in response to DNA damage. Phosphorylation by PRKDC at the C-terminus of XRCC4 and NHEJ1/XLF are highly redundant and regulate ability of the XRCC4- NHEJ1/XLF subcomplex to bridge DNA. Phosphorylation does not prevent interaction with XRCC4 but disrupts ability to bridge DNA and promotes detachment from DNA. Embryonic stem cells are highly sensitive to ionizing radiation and have intrinsic DNA double-strand break repair defects (PubMed:17360556). In contrast, knockout mice only have a relatively mild phenotype with no growth defects, neuronal cell death or overt immunodeficiency (PubMed:18775323). Mature lymphocyte numbers are slightly decreased, and pro-B lines, while ionizing radiation- sensitive, perform V(D)J recombination at nearly wild-type levels (PubMed:18775323). Mice lacking both Paxx and Nhej1/Xlf show embryonic lethality caused by severe defects in classical non-homologous end joining (NHEJ) (PubMed:27601299, PubMed:27798842, PubMed:27601633, PubMed:27830975, PubMed:28051062, PubMed:29077092). Mice lacking both Cyren and Nhej1/Xlf show embryonic lethality caused by severe defects in classical non-homologous end joining (NHEJ) (PubMed:30017584). Belongs to the XRCC4-XLF family. XLF subfamily. Sequence=BAB24611.1; Type=Erroneous initiation; Evidence=; fibrillar center DNA binding nucleus DNA repair double-strand break repair double-strand break repair via nonhomologous end joining cellular response to DNA damage stimulus response to ionizing radiation B cell differentiation T cell differentiation DNA ligase IV complex DNA end binding nonhomologous end joining complex uc287jhf.1 uc287jhf.2 
ENSMUST00000152862.2 Ppp2r2cos ENSMUST00000152862.2 protein phosphatase 2, regulatory subunit B, gamma, opposite strand (from RefSeq NR_045505.1) ENSMUST00000152862.1 NR_045505 uc029vhf.1 uc029vhf.2 uc029vhf.1 uc029vhf.2 
ENSMUST00000152863.2 Gm15392 ENSMUST00000152863.2 Gm15392 (from geneSymbol) ENSMUST00000152863.1 uc287lgm.1 uc287lgm.2 uc287lgm.1 uc287lgm.2 
ENSMUST00000152910.3 Acte1 ENSMUST00000152910.3 actin, epsilon 1, transcript variant 4 (from RefSeq NM_001369837.1) Acte1 D3YYH9 D3YYH9_MOUSE ENSMUST00000152910.1 ENSMUST00000152910.2 Gm498 NM_001369837 uc291xox.1 uc291xox.2 Belongs to the actin family. stress fiber molecular_function striated muscle thin filament actin filament actin cytoskeleton skeletal muscle thin filament assembly uc291xox.1 uc291xox.2 
ENSMUST00000152916.2 Tsix ENSMUST00000152916.2 X (inactive)-specific transcript, opposite strand (from RefSeq NR_002844.2) ENSMUST00000152916.1 NR_002844 uc012hnd.1 uc012hnd.2 uc012hnd.1 uc012hnd.2 
ENSMUST00000152923.2 Gm13165 ENSMUST00000152923.2 Gm13165 (from geneSymbol) ENSMUST00000152923.1 uc290rqf.1 uc290rqf.2 uc290rqf.1 uc290rqf.2 
ENSMUST00000152938.9 Yjefn3 ENSMUST00000152938.9 YjeF N-terminal domain containing 3 (from RefSeq NM_001353930.2) Aibp2 ENSMUST00000152938.1 ENSMUST00000152938.2 ENSMUST00000152938.3 ENSMUST00000152938.4 ENSMUST00000152938.5 ENSMUST00000152938.6 ENSMUST00000152938.7 ENSMUST00000152938.8 F6W8I0 J3QM68 NM_001353930 Q8R2K0 YJEN3_MOUSE Yjefn3 uc009lyc.1 uc009lyc.2 uc009lyc.3 May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence (By similarity). May play a role in spermiogenesis and oogenesis (By similarity). Interacts with APOA1 (By similarity). Binds to HDL (By similarity). mitochondrion biological_process NADHX epimerase activity NADPHX epimerase activity uc009lyc.1 uc009lyc.2 uc009lyc.3 
ENSMUST00000152954.8 Hars2 ENSMUST00000152954.8 histidyl-tRNA synthetase 2, transcript variant 1 (from RefSeq NM_080636.2) ENSMUST00000152954.1 ENSMUST00000152954.2 ENSMUST00000152954.3 ENSMUST00000152954.4 ENSMUST00000152954.5 ENSMUST00000152954.6 ENSMUST00000152954.7 Harsl NM_080636 Q99KK9 SYHM_MOUSE uc008eor.1 uc008eor.2 uc008eor.3 uc008eor.4 uc008eor.5 This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of histidine to tRNA molecules. Mutations in a similar gene in human have been associated with Perrault syndrome 2 (PRLTS2). [provided by RefSeq, Mar 2015]. Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L- histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665, Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442, ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21; Evidence=; Homodimer. Mitochondrion Belongs to the class-II aminoacyl-tRNA synthetase family. nucleotide binding aminoacyl-tRNA ligase activity histidine-tRNA ligase activity ATP binding cytoplasm mitochondrion mitochondrial matrix cytosol translation histidyl-tRNA aminoacylation ligase activity identical protein binding protein homodimerization activity uc008eor.1 uc008eor.2 uc008eor.3 uc008eor.4 uc008eor.5 
ENSMUST00000152957.3 Gm12326 ENSMUST00000152957.3 predicted gene 12326, transcript variant 1 (from RefSeq NR_166818.1) ENSMUST00000152957.1 ENSMUST00000152957.2 NR_166818 uc287zvg.1 uc287zvg.2 uc287zvg.3 uc287zvg.1 uc287zvg.2 uc287zvg.3 
ENSMUST00000152963.2 Gm12301 ENSMUST00000152963.2 Gm12301 (from geneSymbol) ENSMUST00000152963.1 uc287zbo.1 uc287zbo.2 uc287zbo.1 uc287zbo.2 
ENSMUST00000152968.3 Gm12236 ENSMUST00000152968.3 Gm12236 (from geneSymbol) BC028808 ENSMUST00000152968.1 ENSMUST00000152968.2 uc007izp.1 uc007izp.2 uc007izp.3 uc007izp.4 uc007izp.1 uc007izp.2 uc007izp.3 uc007izp.4 
ENSMUST00000152973.2 Igfl3 ENSMUST00000152973.2 IGF-like family member 3 (from RefSeq NM_001003393.1) ENSMUST00000152973.1 Gm580 IGFL_MOUSE Igfl NM_001003393 Q6B9Z0 mIgfl uc009fjg.1 uc009fjg.2 Probable ligand of the IGFLR1 cell membrane receptor. Homodimer; disulfide-linked. Q6B9Z0; Q3U4N7: Igflr1; NbExp=3; IntAct=EBI-3870418, EBI-3870498; Secreted Highly expressed in skin. Also detected in colon, thymus, mammary gland, lymph node and lung. Up-regulated by Imiquimod. Up-regulated in skin upon tissue inflammation and injury. Belongs to the IGFL family. receptor binding protein binding extracellular region extracellular space biological_process uc009fjg.1 uc009fjg.2 
ENSMUST00000152986.2 Gm12972 ENSMUST00000152986.2 Gm12972 (from geneSymbol) AK040853 ENSMUST00000152986.1 uc290qhh.1 uc290qhh.2 uc290qhh.1 uc290qhh.2 
ENSMUST00000153002.4 Myo3a ENSMUST00000153002.4 myosin IIIA (from RefSeq NM_148413.4) B1AYY3 B1AYY3_MOUSE ENSMUST00000153002.1 ENSMUST00000153002.2 ENSMUST00000153002.3 Myo3a NM_148413 uc289tmv.1 uc289tmv.2 uc289tmv.3 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Lacks conserved residue(s) required for the propagation of feature annotation. nucleotide binding motor activity actin binding protein kinase activity ATP binding protein phosphorylation myosin complex uc289tmv.1 uc289tmv.2 uc289tmv.3 
ENSMUST00000153012.3 Gm11529 ENSMUST00000153012.3 predicted gene 11529 (from RefSeq NR_033524.1) ENSMUST00000153012.1 ENSMUST00000153012.2 NR_033524 uc011ydh.1 uc011ydh.2 uc011ydh.3 uc011ydh.4 uc011ydh.1 uc011ydh.2 uc011ydh.3 uc011ydh.4 
ENSMUST00000153031.2 Sh3rf3 ENSMUST00000153031.2 SH3 domain containing ring finger 3 (from RefSeq NM_172788.3) ENSMUST00000153031.1 NM_172788 Posh2 Q3V0K8 Q3V0Q0 Q8C120 SH3R3_MOUSE Sh3md4 uc007fdk.1 uc007fdk.2 uc007fdk.3 uc007fdk.4 Has E3 ubiquitin-protein ligase activity. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts (via SH3 domain 3) with PAK2. Interacts with RAC1 (GTP-bound form). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8C120-1; Sequence=Displayed; Name=2; IsoId=Q8C120-2; Sequence=VSP_024719; Name=3; IsoId=Q8C120-3; Sequence=VSP_024718, VSP_024720, VSP_024721, VSP_024722, VSP_024723; Name=4; IsoId=Q8C120-4; Sequence=VSP_024724, VSP_024725; The RING finger domain is required for ubiquitin ligase activity and autoubiquitination. Autoubiquitinated. Belongs to the SH3RF family. cellular_component apoptotic process protein ubiquitination transferase activity regulation of JNK cascade positive regulation of JNK cascade metal ion binding protein autoubiquitination ubiquitin protein ligase activity uc007fdk.1 uc007fdk.2 uc007fdk.3 uc007fdk.4 
ENSMUST00000153060.8 Rit2 ENSMUST00000153060.8 Ras-like without CAAX 2 (from RefSeq NM_009065.2) ENSMUST00000153060.1 ENSMUST00000153060.2 ENSMUST00000153060.3 ENSMUST00000153060.4 ENSMUST00000153060.5 ENSMUST00000153060.6 ENSMUST00000153060.7 NM_009065 P70425 Q3UST1 Q3UUP4 Q8BQT5 Q9QWX5 RIT2_MOUSE Rin Roc2 uc008ehx.1 uc008ehx.2 uc008ehx.3 Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Alternates between an inactive form bound to GDP and an active form bound to GTP. Interacts with PLXNB3 (By similarity). Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Binds calmodulin. Interacts with POU4F1 (via N-terminus); the interaction controls POU4F1 transactivation activity on some neuronal target genes (PubMed:12934100). P70425; Q13129: RLF; Xeno; NbExp=2; IntAct=EBI-2649620, EBI-958266; Nucleus Cell membrane Note=Colocalizes with PLXNB3 at the plasma membrane. Expressed in ganglion cell layer (GCL), inner plexiform layer (IPL) and inner nuclear layer (INL) of the retina. Expressed in retinal ganglion cells (RGCs). Expressed in horizontal, bipolar and amacrine cells, but not Mueller glia, of the INL (at protein level). Neuron-specific (PubMed:8824319). Expressed in ganglion cell layer (GCL) and inner plexiform layer (IPL) (PubMed:23805044). Expressed weakly in ganglion cell layer (GCL) and inner neuroblastic layer (NBL) of the embryonic retina at 15.5 dpc. Expression increases progressively in the retina from new borns at postnatal day 2 (P2), P5, P15 to 8 week-old adult (at protein level). Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members. Belongs to the small GTPase superfamily. Ras family. Sequence=BAE23581.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding regulation of protein phosphorylation chromatin binding GTPase activity protein binding calmodulin binding GTP binding nucleus cytoplasm plasma membrane signal transduction adenylate cyclase-activating G-protein coupled receptor signaling pathway Ras protein signal transduction positive regulation of neuron projection development negative regulation of neuron projection development membrane GDP binding regulation of endocytosis semaphorin receptor binding regulation of Cdc42 protein signal transduction maintenance of protein location in cell intracellular signal transduction neuron projection positive regulation of MAPK cascade cell body membrane raft positive regulation of transcription from RNA polymerase II promoter regulation of calcium-mediated signaling dendritic tree MAPK cascade regulation of ERK1 and ERK2 cascade uc008ehx.1 uc008ehx.2 uc008ehx.3 
ENSMUST00000153087.2 Gm22000 ENSMUST00000153087.2 Gm22000 (from geneSymbol) AK139889 ENSMUST00000153087.1 uc288cvw.1 uc288cvw.2 uc288cvw.1 uc288cvw.2 
ENSMUST00000153089.3 Gm15819 ENSMUST00000153089.3 Gm15819 (from geneSymbol) ENSMUST00000153089.1 ENSMUST00000153089.2 uc290vsp.1 uc290vsp.2 uc290vsp.1 uc290vsp.2 
ENSMUST00000153102.9 Asxl2 ENSMUST00000153102.9 ASXL transcriptional regulator 2, transcript variant 2 (from RefSeq NM_172421.6) Asxl2 D6REV1 D6REV1_MOUSE ENSMUST00000153102.1 ENSMUST00000153102.2 ENSMUST00000153102.3 ENSMUST00000153102.4 ENSMUST00000153102.5 ENSMUST00000153102.6 ENSMUST00000153102.7 ENSMUST00000153102.8 F8VQA8 NM_172421 uc033gcg.1 uc033gcg.2 uc033gcg.3 uc033gcg.4 This gene encodes a homolog of the Drosophila Asx gene, which interacts with genes involved in axial patterning. Mice with mutations in this gene display abnormal patterning of the axial skeleton, suggesting a similar function in mice as in Drosophila. This gene may also be involved in bone mineral density, specifically osteoclastogenesis. [provided by RefSeq, Aug 2012]. Nucleus Belongs to the Asx family. DNA binding transcription, DNA-templated regulation of transcription, DNA-templated uc033gcg.1 uc033gcg.2 uc033gcg.3 uc033gcg.4 
ENSMUST00000153106.2 Gm16130 ENSMUST00000153106.2 predicted gene 16130 (from RefSeq NR_168941.1) ENSMUST00000153106.1 NR_168941 uc009pwe.1 uc009pwe.2 uc009pwe.3 uc009pwe.1 uc009pwe.2 uc009pwe.3 
ENSMUST00000153118.3 Tpsab1 ENSMUST00000153118.3 Tpsab1 (from geneSymbol) E9PY32 E9PY32_MOUSE ENSMUST00000153118.1 ENSMUST00000153118.2 NM_031187 Tpsab1 uc289iip.1 uc289iip.2 uc289iip.3 serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc289iip.1 uc289iip.2 uc289iip.3 
ENSMUST00000153128.2 Cnnm4 ENSMUST00000153128.2 cyclin M4 (from RefSeq NM_033570.2) Acdp4 CNNM4_MOUSE ENSMUST00000153128.1 Kiaa1592 NM_033570 Q69ZF7 Q9JIM7 uc007aqg.1 uc007aqg.2 uc007aqg.3 uc007aqg.4 Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. Interacts with COX11. Cell membrane ; Multi-pass membrane protein Cornea, retina, teeth (at protein level). In the retina it is predominantly localized to the outer plexiform layer, inner plexiform layer and ganglion cell layer. In the tooth strongest expression is observed in the cell body of the ameloblasts. Expressed at high levels in the gastrointestinal tract and testis. Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo. Belongs to the ACDP family. Sequence=AAF86375.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32487.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; plasma membrane ion transport visual perception magnesium ion homeostasis sodium ion transmembrane transporter activity magnesium ion transmembrane transporter activity magnesium ion transport membrane integral component of membrane basolateral plasma membrane transmembrane transporter activity dendrite biomineral tissue development macromolecular complex sodium ion transmembrane transport neuronal cell body response to stimulus metal ion homeostasis transmembrane transport enamel mineralization magnesium ion transmembrane transport uc007aqg.1 uc007aqg.2 uc007aqg.3 uc007aqg.4 
ENSMUST00000153148.8 Wdr54 ENSMUST00000153148.8 When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. (from UniProt Q9R0D8) BC017608 D3Mm3e ENSMUST00000153148.1 ENSMUST00000153148.2 ENSMUST00000153148.3 ENSMUST00000153148.4 ENSMUST00000153148.5 ENSMUST00000153148.6 ENSMUST00000153148.7 Q3U4A4 Q9R0D8 WDR54_MOUSE Wdr54 uc009cmw.1 uc009cmw.2 uc009cmw.3 uc009cmw.4 When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. Homodimer and homotrimer; forms tight forms of dimers and trimers. Vesicle Note=Aggregates in vesicles when cross-linked. WD6 repeat is required for cross-linking by TGM2. Cross-linked to tightly form both dimers and trimers by TGM2. Cross-linking enhances the activation of EGF receptor-mediated signaling pathway. Cross-linking is inhibited by EGF. Ubiquitinated. EGF increases ubiquitination. negative regulation of receptor internalization biological_process vesicle regulation of epidermal growth factor receptor signaling pathway protein homodimerization activity regulation of MAPK cascade uc009cmw.1 uc009cmw.2 uc009cmw.3 uc009cmw.4 
ENSMUST00000153153.2 Gm12068 ENSMUST00000153153.2 Gm12068 (from geneSymbol) AK148130 ENSMUST00000153153.1 uc287xav.1 uc287xav.2 uc287xav.1 uc287xav.2 
ENSMUST00000153181.9 Gm12359 ENSMUST00000153181.9 Gm12359 (from geneSymbol) AK142978 ENSMUST00000153181.1 ENSMUST00000153181.2 ENSMUST00000153181.3 ENSMUST00000153181.4 ENSMUST00000153181.5 ENSMUST00000153181.6 ENSMUST00000153181.7 ENSMUST00000153181.8 uc288bzz.1 uc288bzz.2 uc288bzz.3 uc288bzz.1 uc288bzz.2 uc288bzz.3 
ENSMUST00000153183.8 Tbl2 ENSMUST00000153183.8 transducin (beta)-like 2, transcript variant 1 (from RefSeq NM_013763.3) ENSMUST00000153183.1 ENSMUST00000153183.2 ENSMUST00000153183.3 ENSMUST00000153183.4 ENSMUST00000153183.5 ENSMUST00000153183.6 ENSMUST00000153183.7 NM_013763 Q8CFY0 Q9R099 TBL2_MOUSE uc008zxu.1 uc008zxu.2 uc008zxu.3 endoplasmic reticulum protein kinase binding endoplasmic reticulum unfolded protein response translation initiation factor binding cellular response to glucose starvation phosphoprotein binding cellular response to hypoxia uc008zxu.1 uc008zxu.2 uc008zxu.3 
ENSMUST00000153191.8 Chid1 ENSMUST00000153191.8 chitinase domain containing 1, transcript variant 5 (from RefSeq NM_001369352.1) CHID1_MOUSE ENSMUST00000153191.1 ENSMUST00000153191.2 ENSMUST00000153191.3 ENSMUST00000153191.4 ENSMUST00000153191.5 ENSMUST00000153191.6 ENSMUST00000153191.7 NM_001369352 Q3TVF7 Q6P8U4 Q8C7C5 Q922Q9 Q9CXR7 uc291xfh.1 uc291xfh.2 Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity). Interacts with STAB1. Secreted. Lysosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q922Q9-1; Sequence=Displayed; Name=2; IsoId=Q922Q9-2; Sequence=VSP_023827; Belongs to the glycosyl hydrolase 18 family. Sequence=AAH61063.1; Type=Erroneous initiation; Evidence=; Sequence=BAB29142.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC34365.1; Type=Erroneous initiation; Evidence=; Sequence=BAE35662.1; Type=Erroneous initiation; Evidence=; immune system process extracellular region extracellular space lysosome late endosome trans-Golgi network carbohydrate metabolic process chitin binding innate immune response oligosaccharide binding negative regulation of cytokine production involved in inflammatory response uc291xfh.1 uc291xfh.2 
ENSMUST00000153208.3 Gm14198 ENSMUST00000153208.3 Gm14198 (from geneSymbol) ENSMUST00000153208.1 ENSMUST00000153208.2 uc290bpb.1 uc290bpb.2 uc290bpb.3 uc290bpb.1 uc290bpb.2 uc290bpb.3 
ENSMUST00000153250.9 Pax9 ENSMUST00000153250.9 Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. (from UniProt Q3V1K1) AK132404 ENSMUST00000153250.1 ENSMUST00000153250.2 ENSMUST00000153250.3 ENSMUST00000153250.4 ENSMUST00000153250.5 ENSMUST00000153250.6 ENSMUST00000153250.7 ENSMUST00000153250.8 Pax9 Q3V1K1 Q3V1K1_MOUSE uc288gmx.1 uc288gmx.2 Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. Interacts with KDM5B. Nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development animal organ morphogenesis negative regulation of transcription, DNA-templated uc288gmx.1 uc288gmx.2 
ENSMUST00000153253.2 Gm16031 ENSMUST00000153253.2 Gm16031 (from geneSymbol) ENSMUST00000153253.1 uc289bng.1 uc289bng.2 uc289bng.1 uc289bng.2 
ENSMUST00000153273.3 Lrrc37a ENSMUST00000153273.3 Lrrc37a (from geneSymbol) B1AWG4 B1AWG4_MOUSE ENSMUST00000153273.1 ENSMUST00000153273.2 Lrrc37a uc288cug.1 uc288cug.2 uc288cug.3 molecular_function cellular_component biological_process membrane integral component of membrane uc288cug.1 uc288cug.2 uc288cug.3 
ENSMUST00000153283.3 Gm13923 ENSMUST00000153283.3 predicted gene 13923 (from RefSeq NR_166444.1) ENSMUST00000153283.1 ENSMUST00000153283.2 NR_166444 uc289zcl.1 uc289zcl.2 uc289zcl.3 uc289zcl.1 uc289zcl.2 uc289zcl.3 
ENSMUST00000153288.2 Gm10631 ENSMUST00000153288.2 Gm10631 (from geneSymbol) AK135158 ENSMUST00000153288.1 uc292cov.1 uc292cov.2 uc292cov.1 uc292cov.2 
ENSMUST00000153297.3 Plekhd1os ENSMUST00000153297.3 Plekhd1os (from geneSymbol) AK002366 ENSMUST00000153297.1 ENSMUST00000153297.2 uc288hnk.1 uc288hnk.2 uc288hnk.3 uc288hnk.1 uc288hnk.2 uc288hnk.3 
ENSMUST00000153328.2 Gm13849 ENSMUST00000153328.2 Gm13849 (from geneSymbol) ENSMUST00000153328.1 uc291dix.1 uc291dix.2 uc291dix.1 uc291dix.2 
ENSMUST00000153344.3 Gm20421 ENSMUST00000153344.3 Gm20421 (from geneSymbol) ENSMUST00000153344.1 ENSMUST00000153344.2 uc290sje.1 uc290sje.2 uc290sje.1 uc290sje.2 
ENSMUST00000153360.8 Ino80c ENSMUST00000153360.8 INO80 complex subunit C (from RefSeq NM_172625.2) ENSMUST00000153360.1 ENSMUST00000153360.2 ENSMUST00000153360.3 ENSMUST00000153360.4 ENSMUST00000153360.5 ENSMUST00000153360.6 ENSMUST00000153360.7 IN80C_MOUSE NM_172625 Q8BHA0 uc008ego.1 uc008ego.2 uc008ego.3 Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP- binding and the helicase C-terminal domain of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Nucleus fibrillar center molecular_function nucleus DNA repair DNA recombination chromatin remodeling cellular response to DNA damage stimulus Ino80 complex MLL1 complex uc008ego.1 uc008ego.2 uc008ego.3 
ENSMUST00000153366.2 A330008L17Rik ENSMUST00000153366.2 RIKEN cDNA A330008L17 gene (from RefSeq NR_132435.1) ENSMUST00000153366.1 NR_132435 uc009mzs.1 uc009mzs.2 uc009mzs.3 uc009mzs.1 uc009mzs.2 uc009mzs.3 
ENSMUST00000153402.2 9630028H03Rik ENSMUST00000153402.2 9630028H03Rik (from geneSymbol) AK049057 ENSMUST00000153402.1 uc290auf.1 uc290auf.2 uc290auf.1 uc290auf.2 
ENSMUST00000153424.8 Drp2 ENSMUST00000153424.8 dystrophin related protein 2, transcript variant 5 (from RefSeq NM_010078.4) DRP2_MOUSE ENSMUST00000153424.1 ENSMUST00000153424.2 ENSMUST00000153424.3 ENSMUST00000153424.4 ENSMUST00000153424.5 ENSMUST00000153424.6 ENSMUST00000153424.7 NM_010078 Q05AA6 Q61095 Q8C4R1 uc009uga.1 uc009uga.2 uc009uga.3 uc009uga.4 Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells (PubMed:22764250). Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane (PubMed:22764250). Possibly involved in membrane-cytoskeleton interactions of the central nervous system. Interacts with PRX; this enhances phosphorylation (PubMed:22764250). Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (PubMed:11430802). Postsynaptic density Cell projection, dendrite Perikaryon Cell membrane eripheral membrane protein Note=Detected in Schwann cells at periaxonal myelin membranes. Detected in quadriceps nerve Schwann cells (PubMed:22764250). Detected in sciatic nerve (PubMed:11430802, PubMed:22764250). Detected in trigeminal nerve Schwann cells (at protein level) (PubMed:11430802). Detected in brain and spinal cord (PubMed:8640231). Mice with a Schwann cell-specific gene disruption show no obvious impairment of nerve conduction velocity and display no visible defects of their motor skills. After six months, about 6% of their nerve fibers present myelination defects, including myelin outfoldings, focal hypermyelination, and onion bulbs with thin myelin and supernumerary Schwann cells. At the molecular level, Schwann cell- specific gene disruption impairs formation of Cajal bands and location of Prx in patches that colocalize with appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Cytoplasm from mutant Schwann cells forms an annulus under the cell membrane, insted of being strictly compartmentalized. Besides, mutant nerves display increased numbers of Schmidt-Lanterman incisures. protein binding plasma membrane central nervous system development zinc ion binding postsynaptic density membrane cell junction dendrite cell projection perikaryon synapse postsynaptic membrane metal ion binding synapse organization glutamatergic synapse uc009uga.1 uc009uga.2 uc009uga.3 uc009uga.4 
ENSMUST00000153461.3 A430108G06Rik ENSMUST00000153461.3 RIKEN cDNA A430108G06 gene (from RefSeq NR_168001.1) ENSMUST00000153461.1 ENSMUST00000153461.2 NR_168001 uc007iwk.1 uc007iwk.2 uc007iwk.3 uc007iwk.4 uc007iwk.1 uc007iwk.2 uc007iwk.3 uc007iwk.4 
ENSMUST00000153470.9 Hikeshi ENSMUST00000153470.9 heat shock protein nuclear import factor, transcript variant 1 (from RefSeq NM_026304.4) D3YUY2 ENSMUST00000153470.1 ENSMUST00000153470.2 ENSMUST00000153470.3 ENSMUST00000153470.4 ENSMUST00000153470.5 ENSMUST00000153470.6 ENSMUST00000153470.7 ENSMUST00000153470.8 HIKES_MOUSE Hikeshi L7rn6 NM_026304 Q30C40 Q9CZT7 Q9DD02 uc009igh.1 uc009igh.2 uc009igh.3 uc009igh.4 Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin- dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus (By similarity). May also be indirectly required for organization and/or function of the secretory apparatus in Club cells in lung. Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins. Interacts with NUP62 and NUP153 (via F-X-F-G repeats). Interacts with HSPA8. Cytoplasm Cytoplasm, cytosol Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DD02-1; Sequence=Displayed; Name=2; IsoId=Q9DD02-2; Sequence=VSP_043955; Expressed in the central white matter of newborn and adult brain, particularly in regions where oligodendrocytes are generated (PubMed:26545878). During late gestation, it is expressed in lung epithelial cells, whereas perinatal expression is restricted to the bronchiolar epithelium. Mice display severe emphysematous enlargement of the distal respiratory sacs at birth. Club cells display enlargement and disorganization of the Golgi complex and formation of aberrant vesicular structures. Belongs to the OPI10 family. nucleus cytoplasm cytosol protein import into nucleus Golgi organization protein transport lung development Hsp70 protein binding cellular response to heat nuclear import signal receptor activity uc009igh.1 uc009igh.2 uc009igh.3 uc009igh.4 
ENSMUST00000153476.8 Aanat ENSMUST00000153476.8 arylalkylamine N-acetyltransferase, transcript variant 1 (from RefSeq NM_009591.3) Aanat ENSMUST00000153476.1 ENSMUST00000153476.2 ENSMUST00000153476.3 ENSMUST00000153476.4 ENSMUST00000153476.5 ENSMUST00000153476.6 ENSMUST00000153476.7 NM_009591 Q14A64 Q14A64_MOUSE uc007mlo.1 uc007mlo.2 uc007mlo.3 The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin. Reaction=a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+); Xref=Rhea:RHEA:20497, ChEBI:CHEBI:15378, ChEBI:CHEBI:55469, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:77827; EC=2.3.1.87; Evidence=; Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2. Belongs to the acetyltransferase family. AANAT subfamily. aralkylamine N-acetyltransferase activity cytoplasm cytosol N-terminal protein amino acid acetylation circadian rhythm N-acetyltransferase activity response to light stimulus photoperiodism response to zinc ion response to organic cyclic compound transferase activity melatonin biosynthetic process response to insulin response to cytokine response to prostaglandin E response to copper ion perinuclear region of cytoplasm response to corticosterone response to cAMP response to calcium ion cellular response to cAMP 14-3-3 protein binding response to peptide uc007mlo.1 uc007mlo.2 uc007mlo.3 
ENSMUST00000153488.9 Naa30 ENSMUST00000153488.9 N(alpha)-acetyltransferase 30, NatC catalytic subunit (from RefSeq NM_027492.2) B2RY23 ENSMUST00000153488.1 ENSMUST00000153488.2 ENSMUST00000153488.3 ENSMUST00000153488.4 ENSMUST00000153488.5 ENSMUST00000153488.6 ENSMUST00000153488.7 ENSMUST00000153488.8 Mak3 NAA30_MOUSE NM_027492 Nat12 Q7TN07 Q8CES0 uc007tkc.1 uc007tkc.2 uc007tkc.3 uc007tkc.4 Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate. Reaction=acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]; Xref=Rhea:RHEA:50520, Rhea:RHEA-COMP:12711, Rhea:RHEA-COMP:12712, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133377, ChEBI:CHEBI:133378; EC=2.3.1.256; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl- [protein]; Xref=Rhea:RHEA:50524, Rhea:RHEA-COMP:12713, Rhea:RHEA- COMP:12714, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133379, ChEBI:CHEBI:133380; EC=2.3.1.256; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl- [protein]; Xref=Rhea:RHEA:50528, Rhea:RHEA-COMP:12715, Rhea:RHEA- COMP:12716, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133382, ChEBI:CHEBI:133383; EC=2.3.1.256; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl- [protein]; Xref=Rhea:RHEA:50560, Rhea:RHEA-COMP:12724, Rhea:RHEA- COMP:12725, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133386, ChEBI:CHEBI:133387; EC=2.3.1.256; Evidence=; Reaction=acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]; Xref=Rhea:RHEA:50532, Rhea:RHEA-COMP:12717, Rhea:RHEA-COMP:12718, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133384, ChEBI:CHEBI:133385; EC=2.3.1.256; Evidence=; Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CES0-1; Sequence=Displayed; Name=2; IsoId=Q8CES0-2; Sequence=VSP_031582, VSP_031583; Belongs to the acetyltransferase family. MAK3 subfamily. Sequence=BAC25468.1; Type=Frameshift; Evidence=; peptide alpha-N-acetyltransferase activity nucleus cytoplasm cytosol polysome N-acetyltransferase activity transferase activity transferase activity, transferring acyl groups N-terminal peptidyl-methionine acetylation NatC complex uc007tkc.1 uc007tkc.2 uc007tkc.3 uc007tkc.4 
ENSMUST00000153510.9 Zfp692 ENSMUST00000153510.9 zinc finger protein 692, transcript variant 1 (from RefSeq NM_182996.3) AREBP ENSMUST00000153510.1 ENSMUST00000153510.2 ENSMUST00000153510.3 ENSMUST00000153510.4 ENSMUST00000153510.5 ENSMUST00000153510.6 ENSMUST00000153510.7 ENSMUST00000153510.8 NM_182996 Q3U381 ZN692_MOUSE Zfp692 Znf692 uc007jaw.1 uc007jaw.2 May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway. Nucleus Phosphorylation at Ser-469 results in loss of DNA-binding activity. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus nucleolus metal ion binding uc007jaw.1 uc007jaw.2 
ENSMUST00000153528.8 Rnf170 ENSMUST00000153528.8 ring finger protein 170, transcript variant 2 (from RefSeq NM_001357292.1) A6H618 ENSMUST00000153528.1 ENSMUST00000153528.2 ENSMUST00000153528.3 ENSMUST00000153528.4 ENSMUST00000153528.5 ENSMUST00000153528.6 ENSMUST00000153528.7 NM_001357292 Q3U796 Q78QX6 Q8C8S1 Q8C9I0 Q8CBG9 Q8K0H6 RN170_MOUSE uc012gbo.1 uc012gbo.2 uc012gbo.3 uc012gbo.4 E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Selectively inhibits the TLR3-triggered innate immune response by promoting the 'Lys-48'-linked polyubiquitination and degradation of TLR3 (PubMed:31076723). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Constitutively associated with the ERLIN1/ERLIN 2 complex. Interacts with activated ITPR1. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8CBG9-1; Sequence=Displayed; Name=2; IsoId=Q8CBG9-2; Sequence=VSP_023858; Name=3; IsoId=Q8CBG9-3; Sequence=VSP_023861, VSP_023864; Name=4; IsoId=Q8CBG9-4; Sequence=VSP_023859, VSP_023863; Name=5; IsoId=Q8CBG9-5; Sequence=VSP_023860, VSP_023862; RNF170 deletion mice show increased expression of type I IFNs and proinflammatory cytokines (IL6 and TNF) in peritoneal macrophages. The mRNA levels of type I IFNs and proinflammatory cytokines in the heart and brain are also significantly higher. It is uncertain whether Met-1 or Met-30 is the initiator. Initiation at Met-30 is supported by sequence similarity with mammalian orthologs and by a Kozak context more favorable compared to that at Met-1. molecular_function cellular_component endoplasmic reticulum endoplasmic reticulum membrane biological_process membrane integral component of membrane protein ubiquitination transferase activity metal ion binding ubiquitin protein ligase activity uc012gbo.1 uc012gbo.2 uc012gbo.3 uc012gbo.4 
ENSMUST00000153562.2 Gm15883 ENSMUST00000153562.2 Gm15883 (from geneSymbol) AK143796 ENSMUST00000153562.1 uc291ndn.1 uc291ndn.2 uc291ndn.1 uc291ndn.2 
ENSMUST00000153572.3 4930565N06Rik ENSMUST00000153572.3 RIKEN cDNA 4930565N06 gene (from RefSeq NR_040476.1) ENSMUST00000153572.1 ENSMUST00000153572.2 NR_040476 uc007zdf.1 uc007zdf.2 uc007zdf.3 uc007zdf.1 uc007zdf.2 uc007zdf.3 
ENSMUST00000153577.2 Gm15339 ENSMUST00000153577.2 Gm15339 (from geneSymbol) ENSMUST00000153577.1 uc291vgv.1 uc291vgv.2 uc291vgv.1 uc291vgv.2 
ENSMUST00000153581.4 Oip5os1 ENSMUST00000153581.4 Oip5os1 (from geneSymbol) AK147270 ENSMUST00000153581.1 ENSMUST00000153581.2 ENSMUST00000153581.3 uc008ltx.1 uc008ltx.2 uc008ltx.3 uc008ltx.4 uc008ltx.5 uc008ltx.6 uc008ltx.7 uc008ltx.1 uc008ltx.2 uc008ltx.3 uc008ltx.4 uc008ltx.5 uc008ltx.6 uc008ltx.7 
ENSMUST00000153599.2 Gm11940 ENSMUST00000153599.2 Gm11940 (from geneSymbol) ENSMUST00000153599.1 uc288cbo.1 uc288cbo.2 uc288cbo.1 uc288cbo.2 
ENSMUST00000153600.2 Gm13402 ENSMUST00000153600.2 Gm13402 (from geneSymbol) ENSMUST00000153600.1 uc289umt.1 uc289umt.2 uc289umt.1 uc289umt.2 
ENSMUST00000153609.8 Snrpa1 ENSMUST00000153609.8 small nuclear ribonucleoprotein polypeptide A', transcript variant 1 (from RefSeq NM_021336.4) ENSMUST00000153609.1 ENSMUST00000153609.2 ENSMUST00000153609.3 ENSMUST00000153609.4 ENSMUST00000153609.5 ENSMUST00000153609.6 ENSMUST00000153609.7 NM_021336 P57784 Q3U7R8 Q8K2W4 Q91YW1 Q9JKQ3 RU2A_MOUSE uc009hgy.1 uc009hgy.2 uc009hgy.3 uc009hgy.4 Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. Identified in the spliceosome B complex. Identified in the spliceosome C complex. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B. Contributes to the binding of stem loop IV of U2 snRNA with SNRPB2. Nucleus Belongs to the U2 small nuclear ribonucleoprotein A family. mRNA splicing, via spliceosome RNA binding nucleus nucleoplasm spliceosomal complex U2 snRNP mRNA processing spermatogenesis RNA splicing nuclear body nuclear speck U2 snRNA binding U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome uc009hgy.1 uc009hgy.2 uc009hgy.3 uc009hgy.4 
ENSMUST00000153627.8 Tdp1 ENSMUST00000153627.8 tyrosyl-DNA phosphodiesterase 1, transcript variant 2 (from RefSeq NM_028354.5) B8JJC1 B8JJC1_MOUSE ENSMUST00000153627.1 ENSMUST00000153627.2 ENSMUST00000153627.3 ENSMUST00000153627.4 ENSMUST00000153627.5 ENSMUST00000153627.6 ENSMUST00000153627.7 NM_028354 Tdp1 uc007osg.1 uc007osg.2 uc007osg.3 uc007osg.4 uc007osg.5 Nucleus Belongs to the tyrosyl-DNA phosphodiesterase family. single strand break repair double-stranded DNA binding single-stranded DNA binding nucleus cytoplasm plasma membrane DNA repair double-strand break repair phosphoric diester hydrolase activity 3'-tyrosyl-DNA phosphodiesterase activity intracellular membrane-bounded organelle uc007osg.1 uc007osg.2 uc007osg.3 uc007osg.4 uc007osg.5 
ENSMUST00000153659.2 C230034O21Rik ENSMUST00000153659.2 C230034O21Rik (from geneSymbol) AK043592 ENSMUST00000153659.1 uc290euo.1 uc290euo.2 uc290euo.1 uc290euo.2 
ENSMUST00000153669.2 Gm11915 ENSMUST00000153669.2 Gm11915 (from geneSymbol) ENSMUST00000153669.1 uc290lod.1 uc290lod.2 uc290lod.1 uc290lod.2 
ENSMUST00000153672.2 Gm11638 ENSMUST00000153672.2 Gm11638 (from geneSymbol) AK039104 ENSMUST00000153672.1 uc007lxk.1 uc007lxk.2 uc007lxk.1 uc007lxk.2 
ENSMUST00000153675.3 Gm13572 ENSMUST00000153675.3 predicted gene 13572 (from RefSeq NR_166198.1) ENSMUST00000153675.1 ENSMUST00000153675.2 NR_166198 uc057lda.1 uc057lda.2 uc057lda.3 uc057lda.1 uc057lda.2 uc057lda.3 
ENSMUST00000153685.2 A730081D07Rik ENSMUST00000153685.2 RIKEN cDNA A730081D07 gene (from RefSeq NR_155347.1) ENSMUST00000153685.1 NR_155347 uc007qep.1 uc007qep.2 uc007qep.3 uc007qep.1 uc007qep.2 uc007qep.3 
ENSMUST00000153700.9 Oaz2 ENSMUST00000153700.9 ornithine decarboxylase antizyme 2, transcript variant 1 (from RefSeq NM_010952.3) ENSMUST00000153700.1 ENSMUST00000153700.2 ENSMUST00000153700.3 ENSMUST00000153700.4 ENSMUST00000153700.5 ENSMUST00000153700.6 ENSMUST00000153700.7 ENSMUST00000153700.8 NM_010952 O08608 OAZ2_MOUSE Sez15 uc009qdu.1 uc009qdu.2 uc009qdu.3 The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]. Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:16916800, PubMed:18508777, PubMed:24967154). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338). Interacts with ODC1 and thereby sterically blocks ODC homodimerization (By similarity). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:16916800). Nucleus Event=Ribosomal frameshifting; Named isoforms=1; Comment=A ribosomal frameshift occurs between the codons for Ser-32 and Asp-33. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.; Name=1; IsoId=O08608-1; Sequence=Displayed; Belongs to the ODC antizyme family. protein binding nucleus cytoplasm cytosol polyamine metabolic process polyamine biosynthetic process ornithine decarboxylase inhibitor activity negative regulation of catalytic activity positive regulation of protein catabolic process positive regulation of intracellular protein transport negative regulation of polyamine transmembrane transport uc009qdu.1 uc009qdu.2 uc009qdu.3 
ENSMUST00000153701.2 Gm15230 ENSMUST00000153701.2 Gm15230 (from geneSymbol) ENSMUST00000153701.1 uc292rsu.1 uc292rsu.2 uc292rsu.1 uc292rsu.2 
ENSMUST00000153718.2 Gm12278 ENSMUST00000153718.2 Gm12278 (from geneSymbol) ENSMUST00000153718.1 KY467593 uc287ywm.1 uc287ywm.2 uc287ywm.1 uc287ywm.2 
ENSMUST00000153722.2 Gm16364 ENSMUST00000153722.2 Gm16364 (from geneSymbol) AK045600 ENSMUST00000153722.1 uc287qoz.1 uc287qoz.2 uc287qoz.1 uc287qoz.2 
ENSMUST00000153726.2 Gm13972 ENSMUST00000153726.2 Gm13972 (from geneSymbol) AK083492 ENSMUST00000153726.1 uc289zjo.1 uc289zjo.2 uc289zjo.1 uc289zjo.2 
ENSMUST00000153774.3 Gm15389 ENSMUST00000153774.3 Gm15389 (from geneSymbol) ENSMUST00000153774.1 ENSMUST00000153774.2 uc287kyk.1 uc287kyk.2 uc287kyk.3 uc287kyk.1 uc287kyk.2 uc287kyk.3 
ENSMUST00000153784.8 Adgrg4 ENSMUST00000153784.8 adhesion G protein-coupled receptor G4 (from RefSeq NM_001362885.1) AGRG4_MOUSE B7ZCC9 B7ZCD0 ENSMUST00000153784.1 ENSMUST00000153784.2 ENSMUST00000153784.3 ENSMUST00000153784.4 ENSMUST00000153784.5 ENSMUST00000153784.6 ENSMUST00000153784.7 Gpr112 NM_001362885 uc292ogu.1 uc292ogu.2 Orphan receptor. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B7ZCC9-1; Sequence=Displayed; Name=2; IsoId=B7ZCC9-2; Sequence=VSP_038177, VSP_038178; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. transmembrane signaling receptor activity G-protein coupled receptor activity integral component of plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway membrane integral component of membrane uc292ogu.1 uc292ogu.2 
ENSMUST00000153785.2 Fgf2os ENSMUST00000153785.2 Fgf2os (from geneSymbol) AK044415 ENSMUST00000153785.1 uc290esl.1 uc290esl.2 uc290esl.1 uc290esl.2 
ENSMUST00000153786.4 Gm15767 ENSMUST00000153786.4 Gm15767 (from geneSymbol) ENSMUST00000153786.1 ENSMUST00000153786.2 ENSMUST00000153786.3 uc291kie.1 uc291kie.2 uc291kie.3 uc291kie.4 uc291kie.1 uc291kie.2 uc291kie.3 uc291kie.4 
ENSMUST00000153791.3 Gm12148 ENSMUST00000153791.3 Gm12148 (from geneSymbol) ENSMUST00000153791.1 ENSMUST00000153791.2 uc287xmu.1 uc287xmu.2 uc287xmu.3 uc287xmu.1 uc287xmu.2 uc287xmu.3 
ENSMUST00000153799.8 Sox13 ENSMUST00000153799.8 SRY (sex determining region Y)-box 13, transcript variant 2 (from RefSeq NM_011439.3) ENSMUST00000153799.1 ENSMUST00000153799.2 ENSMUST00000153799.3 ENSMUST00000153799.4 ENSMUST00000153799.5 ENSMUST00000153799.6 ENSMUST00000153799.7 NM_011439 Q04891 Q922L3 SOX13_MOUSE Sox-13 uc007cqk.1 uc007cqk.2 uc007cqk.3 Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:9524265, PubMed:9421502). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (PubMed:26525805). Binds to the gene promoter of MBP and acts as a transcriptional repressor (PubMed:26525805). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (PubMed:17218525, PubMed:23562159, PubMed:30413363). Required for the differentiation of Vgamma2-positive gamma-delta T-cells, a subset of IL17A expressing gamma-delta T-cells (PubMed:23562159). Regulates expression of BLK in the differentiation of IL17A expressing gamma- delta T-cells (PubMed:23562159). Promotes brown adipocyte differentiation (PubMed:27923061). Inhibitor of WNT signaling (By similarity). Homodimer; homodimerization reduces DNA binding efficiency (By similarity). Interacts with isoform 2 of TCF7/TCF1 (via N-terminus); inhibits WNT-mediated transcriptional activity (PubMed:17218525). Interacts with HHEX (via N-terminus); abolishes the SOX13-mediated inhibition of WNT-mediated transcriptional activity via competitive inhibition of the SOX13-TCF7 complex (PubMed:20028982). Nucleus toplasm Expressed in beta-cells in pancreatic islets of Langerhans (at protein level) (PubMed:10871192). Expressed in a subset of invariant natural killer (iNK) T-cells (at protein level) (PubMed:30413363). Expressed in oligodendroglial cells in the spinal cord (at protein level) (PubMed:26525805). In the hematopoietic system, expressed in gamma-delta T-cell lineage, specifically in immature Vgamma2-positive gamma-delta thymocytes, with expression decreasing upon maturation (PubMed:17218525, PubMed:23562159, PubMed:30413363). Expressed in DN1d cells, a subset of DN1 (TCR, CD4 and CD8 negative, also known as TN1) thymocyte progenitors, and in DN2 (also known as TN2) thymocyte progenitors (PubMed:17218525, PubMed:30413363). Expressed in the ovary and kidney (PubMed:9524265). Expressed in the peripheral lymphoid organs (PubMed:17218525). Expressed in the visceral mesoderm of the yolk sac from 9.5 dpc to 15.5 dpc (at protein level) (PubMed:16835393, PubMed:30413363). Expressed in the sclerotome of developing somites and the derivative vertebrae and ribs between 9.5 dpc and 12.5 dpc (PubMed:16835393). Expressed in the rostral perichondrial area and mesenchyme of the limb bud in the prospective arm region and hand plate at 10.5 dpc, proximal mesenchyme expression in the forelimb then decreases between 11.5 dpc and 12.5 dpc until expression is consolidated to the arm regions of the developing limb at 12.5 dpc and forelimb digits at 13.5 dpc (PubMed:16835393). Expressed at variable levels in the prospective forebrain to the hindbrain and all neural tube cell layers from 9.5 dpc to postnatal day 6 (P6) (PubMed:16835393, PubMed:26525805). Expressed in immature oligodendrocyte precursor cells and astrocytes at 15.5 dpc, additionally expressed in precursor and differentiating oligodendrocytes in the neural tube from 18.5 dpc to P6 (PubMed:26525805). Highly expressed in embryonic arterial walls at 13.5 dpc (PubMed:9421502). Low levels are found in the inner ear at 13.5 dpc and in some cells in the thymus at 16.5 dpc (PubMed:9421502). Initially expressed in the hair follicles of the whisker pad vibrissae at 14.5 dpc, expression continues in the hair placode and in hair germ and peg during hair follicle morphogenesis to 18 dpc (PubMed:9421502, PubMed:30638933). Expressed in the newborn hair follicle epithelial sheath, this expression weakens at P15, reexpressed in the hair follicle bulge and secondary germ regions at P22, with expression continuing in the root sheath of the hair follicle at P28 (PubMed:30638933). Expressed in trophoblast giant cells of the spongiotrophoblast and labyrinth layers of the placenta at 15.5 dpc (PubMed:16835393). Expressed in DN1d cells, a subset of DN1 precursor thymocytes, from 16 dpc onwards (PubMed:30413363). Expressed in the tracheal epithelium below the vocal cord at 18 dpc (PubMed:9421502). Expression is transiently increased during brown adipocyte differentiation (PubMed:27923061). Mice show severe growth abnormalities (PubMed:17218525). Severe reduction in the number of Rorc and Vgamma2- positive mature thymocytes in fetal and adult mice caused by the loss of Blk expression in Vgamma2-positive immature thymocytes (PubMed:23562159). This results in a severe reduction of Il17a- producing Vgamma2-positive gamma-delta T-cells in the spleen, lymph nodes and dermis (PubMed:17218525, PubMed:23562159). In addition, the number of Vgamma4-positive thymocytes in the fetal thymus is transiently reduced, with levels returning to normal in neonatal and adult mice (PubMed:23562159). Proliferation of CD3, CD4, and CD8- negative (triple negative) thymocytes and gamma-delta thymocytes is increased (PubMed:17218525). Double knockout of Sox13 and Tcf7/Tcf1 shows a reduced number of DN1d cells (PubMed:30413363). No defects in oligodendrocyte precursor cells specification and in their differentiation into myelinating oligodendrocytes (PubMed:26525805). However, in Sox13 and Sox6 double knockout mice, causes a slight increase in the number of prematurely differentiated oligodendrocytes in the spinal tube compared to Sox6 knockout mice (PubMed:26525805). No defects in the integumentary system morphology and in hair development (PubMed:30638933). Sequence=AAH07130.1; Type=Erroneous initiation; Evidence=; Sequence=BAA25786.1; Type=Erroneous initiation; Evidence=; Sequence=CAA04278.1; Type=Miscellaneous discrepancy; Note=Several frameshifts.; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated sequence-specific DNA binding cell fate commitment regulation of gamma-delta T cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc007cqk.1 uc007cqk.2 uc007cqk.3 
ENSMUST00000153810.2 A930031H19Rik ENSMUST00000153810.2 RIKEN cDNA A930031H19 gene (from RefSeq NR_130167.1) ENSMUST00000153810.1 NR_130167 uc008uzy.1 uc008uzy.2 uc008uzy.1 uc008uzy.2 
ENSMUST00000153825.2 Gm11748 ENSMUST00000153825.2 Gm11748 (from geneSymbol) AK049482 ENSMUST00000153825.1 uc288dzi.1 uc288dzi.2 uc288dzi.1 uc288dzi.2 
ENSMUST00000153846.8 Pira13 ENSMUST00000153846.8 Pira13 (from geneSymbol) AK165650 ENSMUST00000153846.1 ENSMUST00000153846.2 ENSMUST00000153846.3 ENSMUST00000153846.4 ENSMUST00000153846.5 ENSMUST00000153846.6 ENSMUST00000153846.7 F6PZL4 F6PZL4_MOUSE Gm15448 Pira13 uc291kqx.1 uc291kqx.2 molecular_function cellular_component biological_process uc291kqx.1 uc291kqx.2 
ENSMUST00000153856.8 Chi3l1 ENSMUST00000153856.8 Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia- induced injury, inflammation and epithelial apoptosis in lung. (from UniProt Q61362) AK051475 B0FEU7 Brp39 CH3L1_MOUSE Chil1 D3Z2P2 ENSMUST00000153856.1 ENSMUST00000153856.2 ENSMUST00000153856.3 ENSMUST00000153856.4 ENSMUST00000153856.5 ENSMUST00000153856.6 ENSMUST00000153856.7 Q3U291 Q4FJW9 Q61362 Q8BKL8 Q99J84 uc287lvs.1 uc287lvs.2 Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia- induced injury, inflammation and epithelial apoptosis in lung. Monomer. Q61362; O88786: Il13ra2; NbExp=12; IntAct=EBI-8392424, EBI-20260800; Q61362; P16110: Lgals3; NbExp=4; IntAct=EBI-8392424, EBI-3508325; Secreted, extracellular space. Cytoplasm. Endoplasmic reticulum. Note=Detected in bronchoalveolar lavage (BAL) fluids. Localizes mainly to endoplasmic reticulum when overexpressed in cells, with some protein also detected throughout the cytoplasm. Event=Alternative splicing, Alternative initiation; Named isoforms=3; Name=1; IsoId=Q61362-1; Sequence=Displayed; Name=2; IsoId=Q61362-2; Sequence=VSP_054524; Name=3; IsoId=Q61362-3; Sequence=VSP_054523; Detected in lung in pulmonary macrophages and alveolar type 2 cells and in bronchoalveolar lavage (BAL) fluids. Expressed in mammary tumor cells (at protein level). Expressed in lung. Not detected in non-inflammatory colon. Up-regulated in colon under several inflammatory conditions. Up-regulated upon pulmonary inflammation elicited by sensitization and challenge with the chitin-free aeroallergen ovalbumin or with chitin- containing antigen house dust mite (HDM) extract. Up-regulated in lungs after S.pneumoniae infection. Up-regulated in splenic cells of mammary tumor-bearing animals. Down-regulated by hyperoxia in lung. Mice are viable, fertile and appear normal, but have defective antigen-induced Th2 inflammatory responses and defective IL-13-induced responses, displaying accelerated cell death responses and diminished M2 macrophage differentiation. Mutant mice are more sensitive to S.pneumoniae infection, displaying enhanced mortality, exacerbated lung injury and decreased bacterial clearance compared to wild-type mice. Mutant mice also have an exacerbated response to hyperoxia, displaying enhanced protein leak, tissue inflammation and chemokine production and premature death. [Isoform 2]: Produced by alternative initiation at Met-9 of isoform 1. [Isoform 3]: May be produced by alternative splicing of isoform 1. Belongs to the glycosyl hydrolase 18 family. Although it belongs to the glycosyl hydrolase 18 family, Leu- 149 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity. Sequence=AAH03780.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH04734.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH05611.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAA63603.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding extracellular region extracellular space cytoplasm endoplasmic reticulum carbohydrate metabolic process apoptotic process inflammatory response activation of NF-kappaB-inducing kinase activity chitin binding response to mechanical stimulus positive regulation of peptidyl-threonine phosphorylation lung development response to tumor necrosis factor positive regulation of angiogenesis positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade response to interleukin-1 response to interleukin-6 cellular response to tumor necrosis factor interleukin-8 secretion uc287lvs.1 uc287lvs.2 
ENSMUST00000153878.8 Pcsk2os2 ENSMUST00000153878.8 proprotein convertase subtilisin/kexin type 2, opposite strand 2 (from RefSeq NR_040625.1) ENSMUST00000153878.1 ENSMUST00000153878.2 ENSMUST00000153878.3 ENSMUST00000153878.4 ENSMUST00000153878.5 ENSMUST00000153878.6 ENSMUST00000153878.7 NR_040625 uc008mqg.1 uc008mqg.2 uc008mqg.1 uc008mqg.2 
ENSMUST00000153879.3 Gm16035 ENSMUST00000153879.3 Gm16035 (from geneSymbol) ENSMUST00000153879.1 ENSMUST00000153879.2 KY468075 uc291bjg.1 uc291bjg.2 uc291bjg.3 uc291bjg.1 uc291bjg.2 uc291bjg.3 
ENSMUST00000153892.2 Sumo2 ENSMUST00000153892.2 small ubiquitin-like modifier 2 (from RefSeq NM_133354.2) A2A9X2 ENSMUST00000153892.1 NM_133354 P55855 P61957 Q542L8 SUMO2_MOUSE Smt3b Smt3h2 Sumo2 uc007mhw.1 uc007mhw.2 uc007mhw.3 Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity). Interacts with SAE2 and UBE2I. Interacts with ZNF451. Identified in a complex with ZNF451 and UBE2I/UBC9, where one ZNF451 interacts with one UBE2I/UBC9 and two SUMO2 chains, one bound to the UBE2I/UBC9 active site and the other to another region of the same UBE2I/UBC9 molecule. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 and SOBP (via SIM domains). Interacts with MTA1. Interacts with HINT1 (PubMed:31088288). Interacts with GCNA (via SIM domains); this interaction allows the GCNA recruitment to DPCs sites (By similarity). Nucleus Nucleus, PML body Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys- 63'-linked polyubiquitination by RNF4 (By similarity). Cleavage of precursor form by SENP1 or SENP2 is necessary for function. Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4- dependent polyubiquitination by the UBE2V1-UBE2N heterodimer. Belongs to the ubiquitin family. SUMO subfamily. transcription corepressor binding nucleus nucleoplasm PML body protein sumoylation SUMO transferase activity ubiquitin protein ligase binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein sumoylation cellular protein localization negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinoid X receptor binding uc007mhw.1 uc007mhw.2 uc007mhw.3 
ENSMUST00000153937.2 4933431K23Rik ENSMUST00000153937.2 4933431K23Rik (from geneSymbol) AK135599 ENSMUST00000153937.1 uc009mhu.1 uc009mhu.2 uc009mhu.1 uc009mhu.2 
ENSMUST00000153951.2 Cyp4x1os ENSMUST00000153951.2 cytochrome P450, family 4, subfamily x, polypeptide 1, opposite strand (from RefSeq NR_131922.1) ENSMUST00000153951.1 NR_131922 uc057bsh.1 uc057bsh.2 uc057bsh.1 uc057bsh.2 
ENSMUST00000153983.8 Mrpl58 ENSMUST00000153983.8 mitochondrial ribosomal protein L58, transcript variant 2 (from RefSeq NM_001347645.1) A2A6T2 A2A6T3 ENSMUST00000153983.1 ENSMUST00000153983.2 ENSMUST00000153983.3 ENSMUST00000153983.4 ENSMUST00000153983.5 ENSMUST00000153983.6 ENSMUST00000153983.7 ICT1_MOUSE Ict1 Mrpl58 NM_001347645 Q3TUL0 Q8R035 Q9CTK1 Q9D1R3 uc007mhj.1 uc007mhj.2 uc007mhj.3 uc007mhj.4 Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit (PubMed:20869366). Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity). Reaction=an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L- amino acid + H(+); Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123, Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191; EC=3.1.1.29; Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R035-1; Sequence=Displayed; Name=2; IsoId=Q8R035-2; Sequence=VSP_014374; Methylation of glutamine in the GGQ triplet by HEMK1. Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily. In contrast to other members of the family, lacks the regions that come into close contact with the mRNA in the ribosomal A-site and determine the STOP codon specificity, explaining the loss of codon specificity for translation release factor activity. translation release factor activity aminoacyl-tRNA hydrolase activity mitochondrion mitochondrial large ribosomal subunit ribosome translation translational termination translation release factor activity, codon nonspecific hydrolase activity mitochondrial translational termination uc007mhj.1 uc007mhj.2 uc007mhj.3 uc007mhj.4 
ENSMUST00000153997.8 Gm20878 ENSMUST00000153997.8 predicted gene, 20878 (from RefSeq NM_001270431.1) A2APU9 A2APU9_MOUSE ENSMUST00000153997.1 ENSMUST00000153997.2 ENSMUST00000153997.3 ENSMUST00000153997.4 ENSMUST00000153997.5 ENSMUST00000153997.6 ENSMUST00000153997.7 F6T205 Gm20878 Gm21586 Gm21953 NM_001270431 uc012dci.1 uc012dci.2 uc012dci.3 uc012dci.4 uc012dci.1 uc012dci.2 uc012dci.3 uc012dci.4 
ENSMUST00000154016.2 Gm15888 ENSMUST00000154016.2 Gm15888 (from geneSymbol) ENSMUST00000154016.1 uc291qkn.1 uc291qkn.2 uc291qkn.1 uc291qkn.2 
ENSMUST00000154032.2 Spryd3 ENSMUST00000154032.2 SPRY domain containing 3 (from RefSeq NM_001033277.3) E9Q9B3 E9Q9B3_MOUSE ENSMUST00000154032.1 NM_001033277 Spryd3 uc011zzy.1 uc011zzy.2 uc011zzy.3 molecular_function cellular_component biological_process uc011zzy.1 uc011zzy.2 uc011zzy.3 
ENSMUST00000154038.4 Gm27206 ENSMUST00000154038.4 Gm27206 (from geneSymbol) ENSMUST00000154038.1 ENSMUST00000154038.2 ENSMUST00000154038.3 uc290cfm.1 uc290cfm.2 uc290cfm.1 uc290cfm.2 
ENSMUST00000154066.2 A430078I02Rik ENSMUST00000154066.2 RIKEN cDNA A430078I02 gene, transcript variant 1 (from RefSeq NR_131125.1) ENSMUST00000154066.1 NR_131125 uc009crz.1 uc009crz.2 uc009crz.3 uc009crz.1 uc009crz.2 uc009crz.3 
ENSMUST00000154068.2 Gm12198 ENSMUST00000154068.2 Gm12198 (from geneSymbol) AK031735 ENSMUST00000154068.1 uc287xwz.1 uc287xwz.2 uc287xwz.1 uc287xwz.2 
ENSMUST00000154098.3 Rnf181 ENSMUST00000154098.3 ring finger protein 181, transcript variant 5 (from RefSeq NM_001331169.1) ENSMUST00000154098.1 ENSMUST00000154098.2 NM_001331169 Q8CEU6 Q9CY62 Q9D2T4 RN181_MOUSE Rnf181 uc009cik.1 uc009cik.2 uc009cik.3 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Directly interacts with ITGA2B and, as a result, with integrin ITGA2B/ITGB3. There is no evidence that integrin ITGA2B/ITGB3 is an endogenous substrate for RNF181-directed ubiquitination. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9CY62-1; Sequence=Displayed; Name=2; IsoId=Q9CY62-2; Sequence=VSP_027006; Name=3; IsoId=Q9CY62-3; Sequence=VSP_027007; Auto-ubiquitinated as part of the enzymatic reaction. Belongs to the RNF181 family. ubiquitin-protein transferase activity cytoplasm protein ubiquitination transferase activity metal ion binding protein autoubiquitination ubiquitin protein ligase activity uc009cik.1 uc009cik.2 uc009cik.3 
ENSMUST00000154109.3 Gm14705 ENSMUST00000154109.3 Gm14705 (from geneSymbol) AK041219 ENSMUST00000154109.1 ENSMUST00000154109.2 uc292omn.1 uc292omn.2 uc292omn.3 uc292omn.1 uc292omn.2 uc292omn.3 
ENSMUST00000154111.8 Dpm1 ENSMUST00000154111.8 dolichyl-phosphate mannosyltransferase subunit 1, catalytic, transcript variant 1 (from RefSeq NM_010072.4) DPM1_MOUSE ENSMUST00000154111.1 ENSMUST00000154111.2 ENSMUST00000154111.3 ENSMUST00000154111.4 ENSMUST00000154111.5 ENSMUST00000154111.6 ENSMUST00000154111.7 NM_010072 O70152 Q9D829 uc008oas.1 uc008oas.2 Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. Reaction=a dolichyl phosphate + GDP-alpha-D-mannose = a dolichyl beta- D-mannosyl phosphate + GDP; Xref=Rhea:RHEA:21184, Rhea:RHEA- COMP:9517, Rhea:RHEA-COMP:9527, ChEBI:CHEBI:57527, ChEBI:CHEBI:57683, ChEBI:CHEBI:58189, ChEBI:CHEBI:58211; EC=2.4.1.83; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 divalent metal cation. ; Protein modification; protein glycosylation. Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; within the complex, directly interacts with DPM3. This interaction may stabilize DPM1. Endoplasmic reticulum. Belongs to the glycosyltransferase 2 family. dolichyl-phosphate-mannose-protein mannosyltransferase activity dolichyl-phosphate beta-D-mannosyltransferase activity mannose binding endoplasmic reticulum endoplasmic reticulum membrane protein glycosylation GPI anchor biosynthetic process membrane transferase activity transferase activity, transferring glycosyl groups dolichol metabolic process GDP-mannose metabolic process dolichol-phosphate-mannose synthase complex protein mannosylation protein O-linked mannosylation alcohol binding intracellular membrane-bounded organelle uc008oas.1 uc008oas.2 
ENSMUST00000154115.3 Tent4b ENSMUST00000154115.3 terminal nucleotidyltransferase 4B, transcript variant 5 (from RefSeq NM_001415003.1) ENSMUST00000154115.1 ENSMUST00000154115.2 F6UPY1 F6UPY1_MOUSE NM_001415003 Papd5 Tent4b uc292bwm.1 uc292bwm.2 uc292bwm.3 RNA binding polynucleotide adenylyltransferase activity RNA polyadenylation uc292bwm.1 uc292bwm.2 uc292bwm.3 
ENSMUST00000154132.8 Vta1 ENSMUST00000154132.8 vesicle (multivesicular body) trafficking 1 (from RefSeq NM_025418.3) ENSMUST00000154132.1 ENSMUST00000154132.2 ENSMUST00000154132.3 ENSMUST00000154132.4 ENSMUST00000154132.5 ENSMUST00000154132.6 ENSMUST00000154132.7 NM_025418 Q9CR26 VTA1_MOUSE uc007ell.1 uc007ell.2 uc007ell.3 Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies (By similarity). Involved in the sorting and down-regulation of EGFR. Interacts with VPS4B. Interacts with CHMP1B. Interacts with CHMP2A; the interaction probably involves the open conformation of (polymerized) CHMP2A. Interacts with CHMP3. Interacts with CHMP5; the interaction involves soluble CHMP5. Interacts with IST1 (By similarity). Cytoplasm Endosome membrane ; Peripheral membrane protein Widely expressed. Expressed in brain, liver, kidney, spleen, lung and heart (at protein level). Belongs to the VTA1 family. protein binding nucleoplasm cytoplasm endosome cytosol protein C-terminus binding endosome membrane protein transport membrane intracellular membrane-bounded organelle viral budding multivesicular body sorting pathway uc007ell.1 uc007ell.2 uc007ell.3 
ENSMUST00000154148.8 Gm37240 ENSMUST00000154148.8 Gm37240 (from geneSymbol) AK147159 E9QAY5 E9QAY5_MOUSE ENSMUST00000154148.1 ENSMUST00000154148.2 ENSMUST00000154148.3 ENSMUST00000154148.4 ENSMUST00000154148.5 ENSMUST00000154148.6 ENSMUST00000154148.7 Gm37240 uc008pqg.1 uc008pqg.2 uc008pqg.3 uc008pqg.4 uc008pqg.5 Golgi membrane phospholipid binding cytoplasm intracellular protein transport protein domain specific binding trans-Golgi network membrane regulation of protein secretion phosphatidylinositol-4-phosphate binding uc008pqg.1 uc008pqg.2 uc008pqg.3 uc008pqg.4 uc008pqg.5 
ENSMUST00000154153.9 Pkd1l1 ENSMUST00000154153.9 Membrane ; Multi- pass membrane protein (from UniProt A0A0A0MQK4) A0A0A0MQK4 A0A0A0MQK4_MOUSE AB061684 ENSMUST00000154153.1 ENSMUST00000154153.2 ENSMUST00000154153.3 ENSMUST00000154153.4 ENSMUST00000154153.5 ENSMUST00000154153.6 ENSMUST00000154153.7 ENSMUST00000154153.8 Pkd1l1 uc007hzo.1 uc007hzo.2 uc007hzo.3 uc007hzo.4 Membrane ; Multi- pass membrane protein Belongs to the polycystin family. Lacks conserved residue(s) required for the propagation of feature annotation. calcium channel activity membrane integral component of membrane calcium channel complex calcium ion transmembrane transport non-motile cilium uc007hzo.1 uc007hzo.2 uc007hzo.3 uc007hzo.4 
ENSMUST00000154154.2 Zfp978 ENSMUST00000154154.2 zinc finger protein 978 (from RefSeq NM_001387381.1) A2A7I1 A2A7I1_MOUSE ENSMUST00000154154.1 NM_001387381 Zfp978 uc290rsb.1 uc290rsb.2 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290rsb.1 uc290rsb.2 
ENSMUST00000154166.8 Enpp5 ENSMUST00000154166.8 ectonucleotide pyrophosphatase/phosphodiesterase 5, transcript variant 7 (from RefSeq NM_001329622.1) A9C479 ENPP5_MOUSE ENSMUST00000154166.1 ENSMUST00000154166.2 ENSMUST00000154166.3 ENSMUST00000154166.4 ENSMUST00000154166.5 ENSMUST00000154166.6 ENSMUST00000154166.7 Enpp5 NM_001329622 Q921P7 Q9EQG7 uc008cpr.1 uc008cpr.2 uc008cpr.3 uc008cpr.4 uc008cpr.5 Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates (PubMed:28898552). Lacks lysopholipase D activity. May play a role in neuronal cell communication (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Secreted Membrane ; Single-pass membrane protein Expressed abundantly in the brain and kidney, and at lower levels in the liver. N-glycosylated. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. catalytic activity nucleotide diphosphatase activity extracellular region plasma membrane integral component of plasma membrane cell communication nucleotide catabolic process membrane integral component of membrane hydrolase activity metal ion binding uc008cpr.1 uc008cpr.2 uc008cpr.3 uc008cpr.4 uc008cpr.5 
ENSMUST00000154169.4 Rell1 ENSMUST00000154169.4 RELT-like 1, transcript variant 1 (from RefSeq NM_145923.5) ENSMUST00000154169.1 ENSMUST00000154169.2 ENSMUST00000154169.3 NM_145923 Q3TVW8 Q3UZH6 Q8K2J7 Q8R3S5 RELL1_MOUSE uc008xmh.1 uc008xmh.2 uc008xmh.3 Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed. Interacts with RELT, RELL2, OXSR1 and PLSCR1. Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2J7-1; Sequence=Displayed; Name=2; IsoId=Q8K2J7-2; Sequence=VSP_032026; Belongs to the RELT family. molecular_function plasma membrane microtubule cytoskeleton membrane integral component of membrane positive regulation of p38MAPK cascade uc008xmh.1 uc008xmh.2 uc008xmh.3 
ENSMUST00000154184.5 Shisa5 ENSMUST00000154184.5 shisa family member 5, transcript variant 2 (from RefSeq NM_026381.5) ENSMUST00000154184.1 ENSMUST00000154184.2 ENSMUST00000154184.3 ENSMUST00000154184.4 NM_026381 Q8BJ86 Q8BJ87 Q8BLE9 Q8K4W3 Q91Z37 Q9CQP5 Q9D7I0 SHSA5_MOUSE Scotin uc009rrq.1 uc009rrq.2 uc009rrq.3 uc009rrq.4 Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. Interacts with PDCD6; PDCD6 can stabilze SHISA5. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Nucleus membrane Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9D7I0-1; Sequence=Displayed; Name=2; IsoId=Q9D7I0-2; Sequence=VSP_029960; Name=3; IsoId=Q9D7I0-3; Sequence=VSP_029957, VSP_029961; Name=4; IsoId=Q9D7I0-5; Sequence=VSP_029958, VSP_029959; Spleen and thymus. Induced in a p53/TP53-dependent manner in response to cellular stress. The proline-rich region is required for endoplasmic reticulum localization. Belongs to the shisa family. Sequence=BAC32331.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; nucleus nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane apoptotic process membrane integral component of membrane nuclear membrane intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator WW domain binding intrinsic apoptotic signaling pathway by p53 class mediator uc009rrq.1 uc009rrq.2 uc009rrq.3 uc009rrq.4 
ENSMUST00000154188.2 Gm15202 ENSMUST00000154188.2 Gm15202 (from geneSymbol) ENSMUST00000154188.1 uc292ros.1 uc292ros.2 uc292ros.1 uc292ros.2 
ENSMUST00000154192.2 Gm13054 ENSMUST00000154192.2 Gm13054 (from geneSymbol) ENSMUST00000154192.1 uc290rtn.1 uc290rtn.2 uc290rtn.1 uc290rtn.2 
ENSMUST00000154208.8 Dhrs3 ENSMUST00000154208.8 dehydrogenase/reductase 3, transcript variant 1 (from RefSeq NM_011303.8) DHRS3_MOUSE ENSMUST00000154208.1 ENSMUST00000154208.2 ENSMUST00000154208.3 ENSMUST00000154208.4 ENSMUST00000154208.5 ENSMUST00000154208.6 ENSMUST00000154208.7 NM_011303 O88876 Q3UAD1 Q91WR0 Q91XC3 Q922A6 Rsdr1 uc008vrn.1 uc008vrn.2 uc008vrn.3 uc008vrn.4 Catalyzes the reduction of all-trans-retinal to all-trans- retinol in the presence of NADPH. Reaction=all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH; Xref=Rhea:RHEA:25033, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.300; Evidence=; Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88876-1; Sequence=Displayed; Name=2; IsoId=O88876-2; Sequence=VSP_050734, VSP_050735; In the embryo, expressed in developing osteogenic and chondrogenic tissues of vertebra, rib, tooth and limb bud. Belongs to the short-chain dehydrogenases/reductases (SDR) family. retinoid metabolic process outflow tract morphogenesis retinol dehydrogenase activity lipid particle membrane integral component of membrane oxidoreductase activity regulation of ossification retinol metabolic process regulation of retinoic acid receptor signaling pathway negative regulation of retinoic acid receptor signaling pathway NADP-retinol dehydrogenase activity oxidation-reduction process palate development bone morphogenesis cardiac septum morphogenesis uc008vrn.1 uc008vrn.2 uc008vrn.3 uc008vrn.4 
ENSMUST00000154241.8 Mpv17 ENSMUST00000154241.8 MpV17 mitochondrial inner membrane protein, transcript variant 1 (from RefSeq NM_008622.6) ENSMUST00000154241.1 ENSMUST00000154241.2 ENSMUST00000154241.3 ENSMUST00000154241.4 ENSMUST00000154241.5 ENSMUST00000154241.6 ENSMUST00000154241.7 MPV17_MOUSE NM_008622 P19258 uc008wxf.1 uc008wxf.2 uc008wxf.3 uc008wxf.4 uc008wxf.5 Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (By similarity). Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (PubMed:26760297). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (Probable). Mitochondrion inner membrane ; Multi-pass membrane protein High levels in heart, kidney, and brain, intermediate levels in testis, and low levels in liver and spleen. Mice lack expression of this protein resulting in the development of adult onset nephrotic syndrome and chronic renal failure. They also develop severe morphological degeneration of the inner ear. In the inner ear, mice lacking Mpv17 display degenerative changes of the cochlear structures already at the age of 2 months. The degenerative changes are patchy arranged throughout the entire length of the cochlea and involved the organ of Corti as well as the stria vascularis epithelia with alterations of the basement membrane of the capillaries. Belongs to the peroxisomal membrane protein PXMP2/4 family. Was initially thought to be a peroxisomal protein (PubMed:7957077). However, it was later shown in human that it is a mitochondrial protein (PubMed:16582907, PubMed:16582910). mitochondrial genome maintenance cytoplasm mitochondrion mitochondrial inner membrane peroxisome membrane integral component of membrane glomerular basement membrane development cellular response to reactive oxygen species homeostatic process inner ear development reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process uc008wxf.1 uc008wxf.2 uc008wxf.3 uc008wxf.4 uc008wxf.5 
ENSMUST00000154246.2 2810430I11Rik ENSMUST00000154246.2 2810430I11Rik (from geneSymbol) AK019269 ENSMUST00000154246.1 uc289ujn.1 uc289ujn.2 uc289ujn.1 uc289ujn.2 
ENSMUST00000154256.3 Zfp703 ENSMUST00000154256.3 zinc finger protein 703, transcript variant 1 (from RefSeq NM_001101502.1) ENSMUST00000154256.1 ENSMUST00000154256.2 NM_001101502 P0CL69 ZN703_MOUSE Zeppo1 Znf703 Zpo1 uc012gbq.1 uc012gbq.2 uc012gbq.3 Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. Interacts with DCAF7 and PHB2 (By similarity). Interacts with TLE4; increases transcriptional repression. Nucleus Cytoplasm Expressed in mammary epithelium. Expressed in mammary placodes from 11.5 dpc onward and in the developing intestinal epithelium. Belongs to the Elbow/Noc family. nucleic acid binding nucleus cytoplasm regulation of transcription, DNA-templated positive regulation of cell proliferation positive regulation of epithelial to mesenchymal transition nuclear matrix regulation of transforming growth factor beta receptor signaling pathway positive regulation of cell migration macromolecular complex positive regulation of mammary gland epithelial cell proliferation negative regulation of homotypic cell-cell adhesion adherens junction assembly negative regulation of transcription, DNA-templated metal ion binding regulation of cell cycle mammary gland epithelial cell differentiation regulation of canonical Wnt signaling pathway repressing transcription factor binding cellular response to estradiol stimulus uc012gbq.1 uc012gbq.2 uc012gbq.3 
ENSMUST00000154279.3 L1td1 ENSMUST00000154279.3 LINE-1 type transposase domain containing 1 (from RefSeq NM_001081202.1) ENSMUST00000154279.1 ENSMUST00000154279.2 Ecat11 LITD1_MOUSE NM_001081202 Q3UKY3 Q587J6 uc008tuj.1 uc008tuj.2 uc008tuj.3 Belongs to the transposase 22 family. Sequence=BAE26668.1; Type=Erroneous initiation; Evidence=; single-stranded RNA binding transposition, RNA-mediated ribonucleoprotein complex uc008tuj.1 uc008tuj.2 uc008tuj.3 
ENSMUST00000154294.8 Ccdc42 ENSMUST00000154294.8 coiled-coil domain containing 42 (from RefSeq NM_177779.3) B9EHU2 CCD42_MOUSE Ccdc42 ENSMUST00000154294.1 ENSMUST00000154294.2 ENSMUST00000154294.3 ENSMUST00000154294.4 ENSMUST00000154294.5 ENSMUST00000154294.6 ENSMUST00000154294.7 NM_177779 Q5SV66 Q8BNY1 uc011xwr.1 uc011xwr.2 uc011xwr.3 Required for sperm development. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5SV66-1; Sequence=Displayed; Name=2; IsoId=Q5SV66-2; Sequence=VSP_018334, VSP_018335; Only expressed in the brain and developing sperm. Expression in the testes appears at approximately ten days of age and is maintained into adulthood, corresponding with the onset of meiosis. Expression in the testes appears limited to adluminal spermatids that are engaged in the assembly of flagella. Strong expression is observed in the spermatids within the lumen of the seminiferous tubules in testes from 8-week-old mice, but not in cells adjacent to the basement membrane of the tubule, including Sertoli cells, spermatogonia and spermatocytes. Not expressed in ovaries. Mice develop normally without obvious somatic defects but males are sterile due to malformation of the sperm flagella. Sperm cells display defects in the number and location of the head-tail coupling apparatus and lack flagellated sperm. Belongs to the CFAP73 family. molecular_function cellular_component spermatid development uc011xwr.1 uc011xwr.2 uc011xwr.3 
ENSMUST00000154297.3 Gm13661 ENSMUST00000154297.3 Gm13661 (from geneSymbol) ENSMUST00000154297.1 ENSMUST00000154297.2 uc289xfl.1 uc289xfl.2 uc289xfl.3 uc289xfl.1 uc289xfl.2 uc289xfl.3 
ENSMUST00000154314.2 Gm4279 ENSMUST00000154314.2 Gm4279 (from geneSymbol) AK038889 ENSMUST00000154314.1 uc289cme.1 uc289cme.2 uc289cme.1 uc289cme.2 
ENSMUST00000154330.2 Mrps24 ENSMUST00000154330.2 mitochondrial ribosomal protein S24, transcript variant 1 (from RefSeq NM_026080.3) ENSMUST00000154330.1 NM_026080 Q9CQV5 RT24_MOUSE uc007hwt.1 uc007hwt.2 uc007hwt.3 Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uS3 family. structural constituent of ribosome mitochondrion mitochondrial small ribosomal subunit ribosome mitochondrial translation uc007hwt.1 uc007hwt.2 uc007hwt.3 
ENSMUST00000154338.2 Gm4128 ENSMUST00000154338.2 Gm4128 (from geneSymbol) ENSMUST00000154338.1 uc290tfv.1 uc290tfv.2 uc290tfv.1 uc290tfv.2 
ENSMUST00000154383.2 Tmem216 ENSMUST00000154383.2 transmembrane protein 216, transcript variant 1 (from RefSeq NM_001277860.1) D3YUA1 ENSMUST00000154383.1 NM_001277860 Q9CQC4 TM216_MOUSE uc033hji.1 uc033hji.2 uc033hji.3 This gene encodes a transmembrane protein which is involved in regulation of signaling and trafficking of associated proteins. In humans, mutations in this gene are associated with ciliopathies including Joubert, Meckel and related syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Part of the tectonic-like complex (also named B9 complex) (PubMed:21725307). Interacts with TMEM107 (By similarity). Membrane ; Multi-pass membrane protein Cytoplasm, cytoskeleton, cilium basal body Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQC4-1; Sequence=Displayed; Name=2; IsoId=Q9CQC4-2; Sequence=VSP_040297; molecular_function cytoplasm cytoskeleton cilium membrane integral component of membrane cell projection organization ciliary transition zone MKS complex cell projection cilium assembly non-motile cilium assembly uc033hji.1 uc033hji.2 uc033hji.3 
ENSMUST00000154452.2 Gm12352 ENSMUST00000154452.2 Gm12352 (from geneSymbol) AK160975 ENSMUST00000154452.1 uc288byj.1 uc288byj.2 uc288byj.1 uc288byj.2 
ENSMUST00000154460.8 Ap3m1 ENSMUST00000154460.8 adaptor-related protein complex 3, mu 1 subunit (from RefSeq NM_018829.4) AP3M1_MOUSE ENSMUST00000154460.1 ENSMUST00000154460.2 ENSMUST00000154460.3 ENSMUST00000154460.4 ENSMUST00000154460.5 ENSMUST00000154460.6 ENSMUST00000154460.7 NM_018829 Q5BKQ6 Q9JKC8 uc007sla.1 uc007sla.2 uc007sla.3 uc007sla.4 Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex. Golgi apparatus. Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Belongs to the adaptor complexes medium subunit family. Golgi apparatus intracellular protein transport anterograde axonal transport protein transport membrane vesicle-mediated transport Rab GTPase binding clathrin adaptor complex cytoplasmic vesicle membrane cytoplasmic vesicle anterograde synaptic vesicle transport axon cytoplasm uc007sla.1 uc007sla.2 uc007sla.3 uc007sla.4 
ENSMUST00000154462.2 Gm12526 ENSMUST00000154462.2 Gm12526 (from geneSymbol) AK153685 ENSMUST00000154462.1 uc290mxj.1 uc290mxj.2 uc290mxj.1 uc290mxj.2 
ENSMUST00000154473.9 Smim29 ENSMUST00000154473.9 small integral membrane protein 29, transcript variant 5 (from RefSeq NM_001413718.1) ENSMUST00000154473.1 ENSMUST00000154473.2 ENSMUST00000154473.3 ENSMUST00000154473.4 ENSMUST00000154473.5 ENSMUST00000154473.6 ENSMUST00000154473.7 ENSMUST00000154473.8 NM_001413718 Q3V2N7 Q8R043 SIM29_MOUSE Smim29 uc008bpe.1 uc008bpe.2 uc008bpe.3 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc008bpe.1 uc008bpe.2 uc008bpe.3 
ENSMUST00000154480.2 Gm13727 ENSMUST00000154480.2 Gm13727 (from geneSymbol) ENSMUST00000154480.1 uc289xfm.1 uc289xfm.2 uc289xfm.1 uc289xfm.2 
ENSMUST00000154520.2 Gm6569 ENSMUST00000154520.2 predicted gene 6569, transcript variant 2 (from RefSeq NM_001374242.1) D3YTM9 D3YTM9_MOUSE ENSMUST00000154520.1 Gm6569 NM_001374242 uc288yqj.1 uc288yqj.2 molecular_function cellular_component biological_process uc288yqj.1 uc288yqj.2 
ENSMUST00000154524.2 Gm14343 ENSMUST00000154524.2 Gm14343 (from geneSymbol) ENSMUST00000154524.1 uc290dke.1 uc290dke.2 uc290dke.1 uc290dke.2 
ENSMUST00000154553.2 Sft2d1 ENSMUST00000154553.2 SFT2 domain containing 1, transcript variant 1 (from RefSeq NM_134114.2) A1L3Q4 ENSMUST00000154553.1 NM_134114 Q5SSN7 SFT2A_MOUSE Sft2d1 uc008ajm.1 uc008ajm.2 uc008ajm.3 May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Membrane ; Multi-pass membrane protein Belongs to the SFT2 family. molecular_function protein transport membrane integral component of membrane vesicle-mediated transport uc008ajm.1 uc008ajm.2 uc008ajm.3 
ENSMUST00000154584.9 Eef1d ENSMUST00000154584.9 eukaryotic translation elongation factor 1 delta, transcript variant 2 (from RefSeq NM_023240.4) ENSMUST00000154584.1 ENSMUST00000154584.2 ENSMUST00000154584.3 ENSMUST00000154584.4 ENSMUST00000154584.5 ENSMUST00000154584.6 ENSMUST00000154584.7 ENSMUST00000154584.8 Eef1d NM_023240 Q80T06 Q80T06_MOUSE uc007whk.1 uc007whk.2 uc007whk.3 uc007whk.4 Belongs to the EF-1-beta/EF-1-delta family. translation elongation factor activity eukaryotic translation elongation factor 1 complex translation translational elongation uc007whk.1 uc007whk.2 uc007whk.3 uc007whk.4 
ENSMUST00000154617.8 Rps6kb1 ENSMUST00000154617.8 ribosomal protein S6 kinase, polypeptide 1, transcript variant 3 (from RefSeq NM_001363162.1) ENSMUST00000154617.1 ENSMUST00000154617.2 ENSMUST00000154617.3 ENSMUST00000154617.4 ENSMUST00000154617.5 ENSMUST00000154617.6 ENSMUST00000154617.7 KS6B1_MOUSE NM_001363162 Q5SWG1 Q8BSK8 Q8CHX0 uc007ksn.1 uc007ksn.2 uc007ksn.3 uc007ksn.4 uc007ksn.5 Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:11493700, PubMed:15060135). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:11493700). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (By similarity). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (By similarity). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (By similarity). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (By similarity). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (By similarity). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (By similarity). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (By similarity). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro- apoptotic function (PubMed:11493700). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (By similarity). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (By similarity). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (By similarity). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (By similarity). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Activation requires multiple phosphorylation events on serine/threonine residues. Activation appears to be first mediated by phosphorylation of multiple sites in the autoinhibitory domain, which facilitates phosphorylation at Thr-412, disrupting the autoinhibitory mechanism and allowing phosphorylation of Thr-252 by PDPK1. The active conformation of the kinase is believed to be stabilized by a mechanism involving three conserved phosphorylation sites located in the kinase domain activation loop (Thr-252) and in the AGC-kinase C-terminal domain (Ser-394 in the middle of the tail/linker region and Thr-412 within a hydrophobic motif at its end). Activated by mTORC1; isoform Alpha I and isoform Alpha II are sensitive to rapamycin, which inhibits activating phosphorylation at Thr-412. Activated by PDPK1 (By similarity). Interacts with PPP1R9A/neurabin-1. Interacts with RPTOR. Interacts with IRS1. Interacts with EIF3B and EIF3C. Interacts with TRAF4. Interacts with POLDIP3. Interacts (via N-terminus) with IER5. Q8BSK8; P23804: Mdm2; NbExp=2; IntAct=EBI-646423, EBI-641788; Cytoplasm Synapse, synaptosome Mitochondrion outer membrane Mitochondrion Note=Colocalizes with URI1 at mitochondrion. Event=Alternative initiation; Named isoforms=2; Name=Alpha I; IsoId=Q8BSK8-1; Sequence=Displayed; Name=Alpha II; IsoId=Q8BSK8-2; Sequence=VSP_018840; The autoinhibitory domain is believed to block phosphorylation within the AGC-kinase C-terminal domain and the activation loop. The TOS (TOR signaling) motif is essential for activation by mTORC1. Phosphorylation at Thr-412 is regulated by mTORC1. The phosphorylation at this site is maintained by an agonist-dependent autophosphorylation mechanism. Activated by phosphorylation at Thr-252 by PDPK1. Dephosphorylation by PPP1CC at Thr-412 in mitochondrion (By similarity). Impairment of body growth. Lethal in combination with Rps6kb2 deficiency. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. G1/S transition of mitotic cell cycle nucleotide binding behavioral fear response skeletal muscle contraction protein kinase activity protein serine/threonine kinase activity ribosomal protein S6 kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane cytosol regulation of translation protein phosphorylation apoptotic process cell cycle signal transduction germ cell development aging response to nutrient long-term memory response to heat response to wounding response to mechanical stimulus response to toxic substance response to glucose cell surface response to organic substance response to organonitrogen compound response to organic cyclic compound skeletal muscle atrophy response to electrical stimulus involved in regulation of muscle adaptation positive regulation of smooth muscle cell migration membrane kinase activity phosphorylation cell migration transferase activity peptidyl-serine phosphorylation cell junction PDZ domain binding response to nutrient levels TOR signaling response to lipopolysaccharide response to insulin cellular response to insulin stimulus cellular response to hormone stimulus response to testosterone response to glucagon response to tumor necrosis factor intracellular signal transduction peptide binding response to drug identical protein binding neuron projection negative regulation of apoptotic process response to amino acid response to leucine response to peptide hormone protein kinase B signaling long-chain fatty acid import synapse response to ethanol positive regulation of translation positive regulation of mitotic cell cycle positive regulation of translational initiation regulation of glucose import negative regulation of insulin receptor signaling pathway perinuclear region of cytoplasm positive regulation of skeletal muscle tissue growth positive regulation of smooth muscle cell proliferation response to glucocorticoid protein phosphatase 2A binding cellular response to interferon-gamma cellular response to growth factor stimulus cellular response to organic cyclic compound cellular response to dexamethasone stimulus negative regulation of extrinsic apoptotic signaling pathway uc007ksn.1 uc007ksn.2 uc007ksn.3 uc007ksn.4 uc007ksn.5 
ENSMUST00000154632.2 BC046251 ENSMUST00000154632.2 cDNA sequence BC046251 (from RefSeq NR_131060.1) ENSMUST00000154632.1 NR_131060 uc009hgq.1 uc009hgq.2 uc009hgq.3 uc009hgq.4 uc009hgq.1 uc009hgq.2 uc009hgq.3 uc009hgq.4 
ENSMUST00000154647.8 Phyhd1 ENSMUST00000154647.8 phytanoyl-CoA dioxygenase domain containing 1, transcript variant 3 (from RefSeq NM_001252570.1) A2AQZ4 ENSMUST00000154647.1 ENSMUST00000154647.2 ENSMUST00000154647.3 ENSMUST00000154647.4 ENSMUST00000154647.5 ENSMUST00000154647.6 ENSMUST00000154647.7 NM_001252570 PHYD1_MOUSE Phyhd1 Q80V68 Q9DB26 uc289urj.1 uc289urj.2 2-oxoglutarate(2OG)-dependent dioxygenase that catalyzes the conversion of 2-oxoglutarate to succinate and CO(2) in an iron- dependent manner. However, does not couple 2OG turnover to the hydroxylation of acyl-coenzyme A derivatives, implying that it is not directly involved in phytanoyl coenzyme-A metabolism. Does not show detectable activity towards fatty acid CoA thioesters. Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Belongs to the PhyH family. PHYHD1 subfamily. Sequence=AAI32272.1; Type=Erroneous initiation; Evidence=; Sequence=AAI32274.1; Type=Erroneous initiation; Evidence=; Sequence=BAB23937.1; Type=Erroneous initiation; Evidence=; Sequence=BAE23715.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process oxidoreductase activity metal ion binding dioxygenase activity oxidation-reduction process uc289urj.1 uc289urj.2 
ENSMUST00000154654.2 Gm13647 ENSMUST00000154654.2 Gm13647 (from geneSymbol) ENSMUST00000154654.1 uc289wvj.1 uc289wvj.2 uc289wvj.1 uc289wvj.2 
ENSMUST00000154668.8 Ndst3 ENSMUST00000154668.8 Glycan metabolism; heparan sulfate biosynthesis. (from UniProt E9PZJ4) E9PZJ4 E9PZJ4_MOUSE ENSMUST00000154668.1 ENSMUST00000154668.2 ENSMUST00000154668.3 ENSMUST00000154668.4 ENSMUST00000154668.5 ENSMUST00000154668.6 ENSMUST00000154668.7 G3UXE3 NM_001429228 Ndst3 uc290jjl.1 uc290jjl.2 Glycan metabolism; heparan sulfate biosynthesis. Glycan metabolism; heparin biosynthesis. Golgi apparatus membrane ; Single-pass type II membrane protein Belongs to the sulfotransferase 1 family. NDST subfamily. sulfotransferase activity heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [heparan sulfate]-glucosamine N-sulfotransferase activity membrane integral component of membrane hydrolase activity heparan sulfate N-acetylglucosaminyltransferase activity uc290jjl.1 uc290jjl.2 
ENSMUST00000154673.3 3010003L21Rik ENSMUST00000154673.3 RIKEN cDNA 3010003L21 gene (from RefSeq NR_144294.1) ENSMUST00000154673.1 ENSMUST00000154673.2 NR_144294 uc009ets.1 uc009ets.2 uc009ets.3 uc009ets.1 uc009ets.2 uc009ets.3 
ENSMUST00000154689.8 Meaf6 ENSMUST00000154689.8 MYST/Esa1-associated factor 6, transcript variant 3 (from RefSeq NR_151472.1) B1ASC6 EAF6_MOUSE ENSMUST00000154689.1 ENSMUST00000154689.2 ENSMUST00000154689.3 ENSMUST00000154689.4 ENSMUST00000154689.5 ENSMUST00000154689.6 ENSMUST00000154689.7 NR_151472 Q2VPQ9 Q9D7J5 uc008uru.1 uc008uru.2 uc008uru.3 uc008uru.4 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5 and the subunits EP400, TRRAP, BRD8, EPC1, DMAP1, RUVBL1, RUVBL2, ING3, actin, ACTL6A, MORF4L1, MORF4L2, MRGBP, YEATS4, VPS72 and MEAF6. Component of the HBO1 complex composed of KAT7/HBO1, MEAF6, ING4 or ING5, and one scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE scaffold (JADE1, JADE2 and JADE3) mediate acetylation of histone H4. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Nucleus, nucleolus Chromosome, centromere, kinetochore Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2VPQ9-1; Sequence=Displayed; Name=2; IsoId=Q2VPQ9-2; Sequence=VSP_022452; Belongs to the EAF6 family. histone acetyltransferase complex chromosome, centromeric region kinetochore condensed chromosome kinetochore nucleus chromosome nucleolus chromatin organization histone acetylation NuA4 histone acetyltransferase complex histone H2A acetylation histone H3-K23 acetylation histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K12 acetylation histone H3-K14 acetylation MOZ/MORF histone acetyltransferase complex NuA3a histone acetyltransferase complex NuA3b histone acetyltransferase complex histone acetyltransferase activity (H3-K23 specific) histone H4-K16 acetylation uc008uru.1 uc008uru.2 uc008uru.3 uc008uru.4 
ENSMUST00000154703.4 1700092E19Rik ENSMUST00000154703.4 RIKEN cDNA 1700092E19 gene (from RefSeq NR_045933.1) ENSMUST00000154703.1 ENSMUST00000154703.2 ENSMUST00000154703.3 NR_045933 uc029rzk.1 uc029rzk.2 uc029rzk.3 uc029rzk.4 uc029rzk.1 uc029rzk.2 uc029rzk.3 uc029rzk.4 
ENSMUST00000154720.2 Gm12971 ENSMUST00000154720.2 Gm12971 (from geneSymbol) ENSMUST00000154720.1 uc290qhd.1 uc290qhd.2 uc290qhd.1 uc290qhd.2 
ENSMUST00000154724.2 Gm21983 ENSMUST00000154724.2 Gm21983 (from geneSymbol) BC087555 D6RFS9 D6RFS9_MOUSE ENSMUST00000154724.1 Gm21983 Mia1 uc291ndv.1 uc291ndv.2 uc291ndv.1 uc291ndv.2 
ENSMUST00000154739.3 1700051A21Rik ENSMUST00000154739.3 1700051A21Rik (from geneSymbol) AK077134 ENSMUST00000154739.1 ENSMUST00000154739.2 uc007jyo.1 uc007jyo.2 uc007jyo.3 uc007jyo.4 uc007jyo.5 uc007jyo.1 uc007jyo.2 uc007jyo.3 uc007jyo.4 uc007jyo.5 
ENSMUST00000154775.2 Gm15638 ENSMUST00000154775.2 predicted gene 15638, transcript variant 1 (from RefSeq NR_152226.1) ENSMUST00000154775.1 NR_152226 uc289exc.1 uc289exc.2 uc289exc.1 uc289exc.2 
ENSMUST00000154780.10 Pasd1 ENSMUST00000154780.10 Pasd1 (from geneSymbol) AK133067 ENSMUST00000154780.1 ENSMUST00000154780.2 ENSMUST00000154780.3 ENSMUST00000154780.4 ENSMUST00000154780.5 ENSMUST00000154780.6 ENSMUST00000154780.7 ENSMUST00000154780.8 ENSMUST00000154780.9 Gm1141 J9JI72 J9JI72_MOUSE Pasd1 uc292ooy.1 uc292ooy.2 uc292ooy.3 molecular_function biological_process uc292ooy.1 uc292ooy.2 uc292ooy.3 
ENSMUST00000154810.3 G530011O06Rikx ENSMUST00000154810.3 RIKEN cDNA G530011O06 gene, transcript variant 1 (from RefSeq NR_029457.1) ENSMUST00000154810.1 ENSMUST00000154810.2 NR_029457 uc009uyi.1 uc009uyi.2 uc009uyi.3 uc009uyi.1 uc009uyi.2 uc009uyi.3 
ENSMUST00000154825.8 9430041J12Rik ENSMUST00000154825.8 RIKEN cDNA 9430041J12 gene (from RefSeq NR_033568.1) ENSMUST00000154825.1 ENSMUST00000154825.2 ENSMUST00000154825.3 ENSMUST00000154825.4 ENSMUST00000154825.5 ENSMUST00000154825.6 ENSMUST00000154825.7 NR_033568 uc009ewv.1 uc009ewv.2 uc009ewv.1 uc009ewv.2 
ENSMUST00000154848.3 Parvaos ENSMUST00000154848.3 parvin, alpha, opposite strand, transcript variant 2 (from RefSeq NR_154467.1) ENSMUST00000154848.1 ENSMUST00000154848.2 NR_154467 uc009jgv.1 uc009jgv.2 uc009jgv.3 uc009jgv.1 uc009jgv.2 uc009jgv.3 
ENSMUST00000154854.3 4930404I05Rik ENSMUST00000154854.3 RIKEN cDNA 4930404I05 gene (from RefSeq NR_028368.1) ENSMUST00000154854.1 ENSMUST00000154854.2 NR_028368 uc007zwy.1 uc007zwy.2 uc007zwy.3 uc007zwy.4 uc007zwy.1 uc007zwy.2 uc007zwy.3 uc007zwy.4 
ENSMUST00000154919.2 9330162012Rik ENSMUST00000154919.2 cDNA RIKEN 9330162012 gene (from RefSeq NR_102323.1) ENSMUST00000154919.1 NR_102323 uc007pwr.1 uc007pwr.2 uc007pwr.3 uc007pwr.4 uc007pwr.1 uc007pwr.2 uc007pwr.3 uc007pwr.4 
ENSMUST00000154946.2 Gm14209 ENSMUST00000154946.2 Gm14209 (from geneSymbol) ENSMUST00000154946.1 uc290auk.1 uc290auk.2 uc290auk.1 uc290auk.2 
ENSMUST00000154947.3 1700125G02Rik ENSMUST00000154947.3 RIKEN cDNA 1700125G02 gene (from RefSeq NR_040651.1) ENSMUST00000154947.1 ENSMUST00000154947.2 NR_040651 uc029uzi.1 uc029uzi.2 uc029uzi.3 uc029uzi.1 uc029uzi.2 uc029uzi.3 
ENSMUST00000154953.2 Gm15624 ENSMUST00000154953.2 Gm15624 (from geneSymbol) AK038985 ENSMUST00000154953.1 uc291gee.1 uc291gee.2 uc291gee.1 uc291gee.2 
ENSMUST00000154987.8 Gm49388 ENSMUST00000154987.8 Gm49388 (from geneSymbol) A0A0U1RNP2 A0A0U1RNP2_MOUSE BC066039 ENSMUST00000154987.1 ENSMUST00000154987.2 ENSMUST00000154987.3 ENSMUST00000154987.4 ENSMUST00000154987.5 ENSMUST00000154987.6 ENSMUST00000154987.7 Gm49388 uc009jwu.1 uc009jwu.2 uc009jwu.3 histone-lysine N-methyltransferase activity histone lysine methylation histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex histone H3-K4 methylation uc009jwu.1 uc009jwu.2 uc009jwu.3 
ENSMUST00000154993.2 Gm14549 ENSMUST00000154993.2 Gm14549 (from geneSymbol) ENSMUST00000154993.1 uc292nsi.1 uc292nsi.2 uc292nsi.1 uc292nsi.2 
ENSMUST00000155020.2 Gm37988 ENSMUST00000155020.2 Gm37988 (from geneSymbol) AK167231 ENSMUST00000155020.1 Gm37988 J3QM41 J3QM41_MOUSE uc287get.1 uc287get.2 uc287get.1 uc287get.2 
ENSMUST00000155023.9 Kazn ENSMUST00000155023.9 kazrin, periplakin interacting protein, transcript variant 1 (from RefSeq NM_144531.4) A2AC34 B1B0N1 ENSMUST00000155023.1 ENSMUST00000155023.2 ENSMUST00000155023.3 ENSMUST00000155023.4 ENSMUST00000155023.5 ENSMUST00000155023.6 ENSMUST00000155023.7 ENSMUST00000155023.8 KAZRN_MOUSE Kaz Kiaa1026 NM_144531 Q69ZS8 Q8BIY2 Q8R1X4 uc290rlc.1 uc290rlc.2 Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. Cell junction Nucleus Cytoplasm, cytoskeleton Note=In an antibody regognizing isoform 2 and isoform 3 has been used. Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q69ZS8-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q69ZS8-2; Sequence=VSP_031905, VSP_031906, VSP_031907; Name=3; Synonyms=C; IsoId=Q69ZS8-3; Sequence=VSP_031904, VSP_031906, VSP_031907; Expressed in skin interfollicular epidermis and hair follicles. Expressed in tongue epithelium basal suprabasal layers. Expressed in eggs and early embryos. Detected in unfertilized eggs associated with the spindle apparatus and cytoskeletal sheets. As quickly as 5 min after egg activation, relocates to a diffuse peri-spindle position, followed 20-30 min later by localization to the presumptive cytokinetic ring. Before the blastocyst stage of development, associates with the nuclear matrix in a cell cycle-dependent manner, and also associates with the cytoplasmic actin cytoskeleton. After blastocyst formation, is found associating with cell-cell junctions, the cytoskeleton and nucleus. Belongs to the kazrin family. Sequence=BAD32368.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cornified envelope nucleus nucleoplasm cytoplasm cytosol cytoskeleton nuclear speck cell junction desmosome keratinization uc290rlc.1 uc290rlc.2 
ENSMUST00000155032.8 A230004M16Rik ENSMUST00000155032.8 A230004M16Rik (from geneSymbol) AK049168 ENSMUST00000155032.1 ENSMUST00000155032.2 ENSMUST00000155032.3 ENSMUST00000155032.4 ENSMUST00000155032.5 ENSMUST00000155032.6 ENSMUST00000155032.7 uc007ima.1 uc007ima.2 uc007ima.3 uc007ima.1 uc007ima.2 uc007ima.3 
ENSMUST00000155046.2 Gm11431 ENSMUST00000155046.2 Gm11431 (from geneSymbol) ENSMUST00000155046.1 uc288aza.1 uc288aza.2 uc288aza.1 uc288aza.2 
ENSMUST00000155101.2 Gm15413 ENSMUST00000155101.2 predicted gene 15413 (from RefSeq NR_045874.1) ENSMUST00000155101.1 NR_045874 uc029wnc.1 uc029wnc.2 uc029wnc.1 uc029wnc.2 
ENSMUST00000155156.2 Gm11846 ENSMUST00000155156.2 Gm11846 (from geneSymbol) ENSMUST00000155156.1 uc290lgf.1 uc290lgf.2 uc290lgf.1 uc290lgf.2 
ENSMUST00000155173.2 Gm14246 ENSMUST00000155173.2 Gm14246 (from geneSymbol) ENSMUST00000155173.1 uc290cgv.1 uc290cgv.2 uc290cgv.1 uc290cgv.2 
ENSMUST00000155180.3 Gm16155 ENSMUST00000155180.3 Gm16155 (from geneSymbol) ENSMUST00000155180.1 ENSMUST00000155180.2 uc287ugj.1 uc287ugj.2 uc287ugj.3 uc287ugj.1 uc287ugj.2 uc287ugj.3 
ENSMUST00000155184.2 Gm16321 ENSMUST00000155184.2 Gm16321 (from geneSymbol) ENSMUST00000155184.1 uc287vdu.1 uc287vdu.2 uc287vdu.1 uc287vdu.2 
ENSMUST00000155203.2 Zbtb10 ENSMUST00000155203.2 zinc finger and BTB domain containing 10 (from RefSeq NM_177660.3) E9Q8X5 E9Q8X5_MOUSE ENSMUST00000155203.1 NM_177660 Zbtb10 uc008ooy.1 uc008ooy.2 uc008ooy.3 uc008ooy.4 uc008ooy.5 negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding nucleic acid binding DNA binding nucleoplasm uc008ooy.1 uc008ooy.2 uc008ooy.3 uc008ooy.4 uc008ooy.5 
ENSMUST00000155206.8 Trpc5os ENSMUST00000155206.8 transient receptor potential cation channel, subfamily C, member 5, opposite strand (from RefSeq NM_001195579.1) ENSMUST00000155206.1 ENSMUST00000155206.2 ENSMUST00000155206.3 ENSMUST00000155206.4 ENSMUST00000155206.5 ENSMUST00000155206.6 ENSMUST00000155206.7 Gm15070 NM_001195579 Q3UHV4 TR5OS_MOUSE uc009umx.1 uc009umx.2 uc009umx.3 Encoded in an intron of the TRPC5 gene (opposite strand). May be a non-coding RNA. uc009umx.1 uc009umx.2 uc009umx.3 
ENSMUST00000155211.2 C030037F17Rik ENSMUST00000155211.2 C030037F17Rik (from geneSymbol) AK021128 ENSMUST00000155211.1 uc009kzc.1 uc009kzc.2 uc009kzc.1 uc009kzc.2 
ENSMUST00000155217.3 Gm15414 ENSMUST00000155217.3 Gm15414 (from geneSymbol) ENSMUST00000155217.1 ENSMUST00000155217.2 uc291sth.1 uc291sth.2 uc291sth.1 uc291sth.2 
ENSMUST00000155218.9 Gabra6 ENSMUST00000155218.9 gamma-aminobutyric acid type A receptor subunit alpha 6, transcript variant 1 (from RefSeq NM_001099641.2) ENSMUST00000155218.1 ENSMUST00000155218.2 ENSMUST00000155218.3 ENSMUST00000155218.4 ENSMUST00000155218.5 ENSMUST00000155218.6 ENSMUST00000155218.7 ENSMUST00000155218.8 GBRA6_MOUSE Gabra-6 NM_001099641 P16305 Q5SUU5 Q9R0V3 Q9R0V4 Q9R0V5 uc007imh.1 uc007imh.2 uc007imh.3 uc007imh.4 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P16305-1; Sequence=Displayed; Name=2; IsoId=P16305-2; Sequence=VSP_000086; Name=3; IsoId=P16305-3; Sequence=VSP_000085; Name=4; IsoId=P16305-4; Sequence=VSP_000085, VSP_000086; Only found in cerebellar granule cells. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub- subfamily. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity inhibitory extracellular ligand-gated ion channel activity chloride channel activity plasma membrane integral component of plasma membrane ion transport chloride transport signal transduction gamma-aminobutyric acid signaling pathway chemical synaptic transmission drug binding membrane integral component of membrane GABA-gated chloride ion channel activity cell junction dendrite dendrite membrane neuronal cell body membrane ion transmembrane transport chloride channel complex regulation of membrane potential presynaptic membrane neuron projection receptor complex synapse postsynaptic membrane neurological system process protein heterooligomerization synaptic transmission, GABAergic regulation of postsynaptic membrane potential postsynapse GABA-ergic synapse integral component of postsynaptic specialization membrane chloride transmembrane transport GABA-A receptor complex transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential benzodiazepine receptor activity uc007imh.1 uc007imh.2 uc007imh.3 uc007imh.4 
ENSMUST00000155224.4 Gm12440 ENSMUST00000155224.4 predicted gene 12440 (from RefSeq NR_110516.1) ENSMUST00000155224.1 ENSMUST00000155224.2 ENSMUST00000155224.3 NR_110516 uc033hyq.1 uc033hyq.2 uc033hyq.3 uc033hyq.4 uc033hyq.1 uc033hyq.2 uc033hyq.3 uc033hyq.4 
ENSMUST00000155329.9 Ankhd1 ENSMUST00000155329.9 ankyrin repeat and KH domain containing 1 (from RefSeq NM_175375.3) Ankhd1 E9PUR0 E9PUR0_MOUSE ENSMUST00000155329.1 ENSMUST00000155329.2 ENSMUST00000155329.3 ENSMUST00000155329.4 ENSMUST00000155329.5 ENSMUST00000155329.6 ENSMUST00000155329.7 ENSMUST00000155329.8 NM_175375 uc008env.1 uc008env.2 uc008env.3 uc008env.4 nucleic acid binding RNA binding cytoplasm innate immune response uc008env.1 uc008env.2 uc008env.3 uc008env.4 
ENSMUST00000155332.2 Gm12592 ENSMUST00000155332.2 predicted gene 12592 (from RefSeq NR_165248.1) ENSMUST00000155332.1 NR_165248 uc287wdc.1 uc287wdc.2 uc287wdc.1 uc287wdc.2 
ENSMUST00000155334.2 Gm14216 ENSMUST00000155334.2 Gm14216 (from geneSymbol) ENSMUST00000155334.1 uc290bph.1 uc290bph.2 uc290bph.1 uc290bph.2 
ENSMUST00000155350.3 Gm13617 ENSMUST00000155350.3 Gm13617 (from geneSymbol) AK144548 ENSMUST00000155350.1 ENSMUST00000155350.2 uc057lde.1 uc057lde.2 uc057lde.3 uc057lde.4 uc057lde.1 uc057lde.2 uc057lde.3 uc057lde.4 
ENSMUST00000155364.8 Mpc1 ENSMUST00000155364.8 mitochondrial pyruvate carrier 1, transcript variant 2 (from RefSeq NR_157360.1) Brp44l ENSMUST00000155364.1 ENSMUST00000155364.2 ENSMUST00000155364.3 ENSMUST00000155364.4 ENSMUST00000155364.5 ENSMUST00000155364.6 ENSMUST00000155364.7 Mpc1 NR_157360 Q3UX28 Q3UX28_MOUSE uc033hao.1 uc033hao.2 uc033hao.3 Mediates the uptake of pyruvate into mitochondria. Reaction=H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in); Xref=Rhea:RHEA:64720, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378; Evidence=; Membrane ; Multi- pass membrane protein Mitochondrion inner membrane ulti-pass membrane protein Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. mitochondrion mitochondrial inner membrane mitochondrial pyruvate transport uc033hao.1 uc033hao.2 uc033hao.3 
ENSMUST00000155384.3 2900041M22Rik ENSMUST00000155384.3 2900041M22Rik (from geneSymbol) AK046435 ENSMUST00000155384.1 ENSMUST00000155384.2 uc007mnh.1 uc007mnh.2 uc007mnh.3 uc007mnh.4 uc007mnh.5 uc007mnh.1 uc007mnh.2 uc007mnh.3 uc007mnh.4 uc007mnh.5 
ENSMUST00000155405.8 Gm49405 ENSMUST00000155405.8 Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA and CoA esters yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products (PubMed:31004344). Hydrolyzes short- and medium-chain acyl-CoAs, exhibiting the highest activity toward free CoA, hexanoyl-CoA, and octanoyl-CoA and the lowest activity against acetyl-CoA (PubMed:31004344). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673). (from UniProt Q9CR24) BC054798 ENSMUST00000155405.1 ENSMUST00000155405.2 ENSMUST00000155405.3 ENSMUST00000155405.4 ENSMUST00000155405.5 ENSMUST00000155405.6 ENSMUST00000155405.7 NUDT8_MOUSE Nudt8 Q3TDQ2 Q9CR24 uc289pzf.1 uc289pzf.2 Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA and CoA esters yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products (PubMed:31004344). Hydrolyzes short- and medium-chain acyl-CoAs, exhibiting the highest activity toward free CoA, hexanoyl-CoA, and octanoyl-CoA and the lowest activity against acetyl-CoA (PubMed:31004344). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673). Reaction=an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'- phosphopantetheine + 2 H(+); Xref=Rhea:RHEA:50044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58342, ChEBI:CHEBI:58343, ChEBI:CHEBI:132023; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50045; Evidence=; Reaction=CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'- bisphosphate + 2 H(+); Xref=Rhea:RHEA:64988, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58343, ChEBI:CHEBI:61723; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64989; Evidence=; Reaction=acetyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S- acetyl-4'-phosphopantetheine; Xref=Rhea:RHEA:64992, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57288, ChEBI:CHEBI:58343, ChEBI:CHEBI:156266; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64993; Evidence=; Reaction=butanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:49976, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57371, ChEBI:CHEBI:58343, ChEBI:CHEBI:132011; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49977; Evidence=; Reaction=H2O + hexanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:49980, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58343, ChEBI:CHEBI:62620, ChEBI:CHEBI:132012; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49981; Evidence=; Reaction=H2O + octanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50016, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57386, ChEBI:CHEBI:58343, ChEBI:CHEBI:132013; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50017; Evidence=; Reaction=H2O + propanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:67464, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57392, ChEBI:CHEBI:58343, ChEBI:CHEBI:172362; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67465; Evidence=; Reaction=H2O + malonyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine; Xref=Rhea:RHEA:67468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57384, ChEBI:CHEBI:58343, ChEBI:CHEBI:172363; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67469; Evidence=; Reaction=H2O + succinyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine; Xref=Rhea:RHEA:67472, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57292, ChEBI:CHEBI:58343, ChEBI:CHEBI:172364; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67473; Evidence=; Reaction=a 5'-end CoA-ribonucleoside in mRNA + H2O = (R)-4'- phosphopantetheine + a 5'-end phospho-adenosine-phospho- ribonucleoside in mRNA + 2 H(+); Xref=Rhea:RHEA:67592, Rhea:RHEA- COMP:15719, Rhea:RHEA-COMP:17276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:61723, ChEBI:CHEBI:144051, ChEBI:CHEBI:172371; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67593; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Kinetic parameters: KM=707 uM for acetyl-CoA ; KM=318 uM for propanol-CoA ; KM=224 uM for butanoyl-CoA ; KM=233 uM for malonyl-CoA ; KM=329 uM for succinyl-CoA ; KM=251 uM for hexanoyl-CoA ; Monomer. Mitochondrion Expressed at the highest levels in the kidneys, heart, brown adipose tissue and liver (at protein level) (PubMed:31004344). Expressed at lower levels in the brain, skeletal muscle, and white adipose tissue (at protein level) (PubMed:31004344). Belongs to the Nudix hydrolase family. mitochondrion biological_process hydrolase activity metal ion binding uc289pzf.1 uc289pzf.2 
ENSMUST00000155430.9 Spdye4c ENSMUST00000155430.9 speedy/RINGO cell cycle regulator family, member E4C (from RefSeq NM_001310641.1) ENSMUST00000155430.1 ENSMUST00000155430.2 ENSMUST00000155430.3 ENSMUST00000155430.4 ENSMUST00000155430.5 ENSMUST00000155430.6 ENSMUST00000155430.7 ENSMUST00000155430.8 Gm355 I6XKQ3 I6XKQ3_MOUSE J3KMS1 NM_001310641 Spdye4c SpyB3 uc290ahz.1 uc290ahz.2 uc290ahz.3 Belongs to the Speedy/Ringo family. cellular_component protein kinase binding uc290ahz.1 uc290ahz.2 uc290ahz.3 
ENSMUST00000155455.3 Gm14330 ENSMUST00000155455.3 Gm14330 (from geneSymbol) ENSMUST00000155455.1 ENSMUST00000155455.2 uc291jtf.1 uc291jtf.2 uc291jtf.1 uc291jtf.2 
ENSMUST00000155466.2 Gm20696 ENSMUST00000155466.2 Gm20696 (from geneSymbol) AK035794 ENSMUST00000155466.1 Gm20696 H3BJN7 H3BJN7_MOUSE uc291hkl.1 uc291hkl.2 RNA 7-methylguanosine cap binding translation initiation factor activity translational initiation eukaryotic translation initiation factor 4F complex uc291hkl.1 uc291hkl.2 
ENSMUST00000155475.2 Gm13417 ENSMUST00000155475.2 Gm13417 (from geneSymbol) ENSMUST00000155475.1 uc289tqn.1 uc289tqn.2 uc289tqn.1 uc289tqn.2 
ENSMUST00000155487.8 Mfsd14b ENSMUST00000155487.8 major facilitator superfamily domain containing 14B, transcript variant 1 (from RefSeq NM_133680.4) ENSMUST00000155487.1 ENSMUST00000155487.2 ENSMUST00000155487.3 ENSMUST00000155487.4 ENSMUST00000155487.5 ENSMUST00000155487.6 ENSMUST00000155487.7 G3UVV2 Hiatl1 MF14B_MOUSE Mfsd14b NM_133680 Q8CIA9 Q8VCW0 uc007qzd.1 uc007qzd.2 uc007qzd.3 Membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. Sequence=AAH18395.1; Type=Erroneous initiation; Evidence=; Sequence=AAH33469.1; Type=Erroneous initiation; Evidence=; Sequence=BAE27291.1; Type=Erroneous initiation; Evidence=; integral component of plasma membrane membrane integral component of membrane transmembrane transporter activity transmembrane transport uc007qzd.1 uc007qzd.2 uc007qzd.3 
ENSMUST00000155496.3 Gm13853 ENSMUST00000155496.3 Gm13853 (from geneSymbol) ENSMUST00000155496.1 ENSMUST00000155496.2 uc291dkc.1 uc291dkc.2 uc291dkc.3 uc291dkc.1 uc291dkc.2 uc291dkc.3 
ENSMUST00000155505.2 Gm11723 ENSMUST00000155505.2 Gm11723 (from geneSymbol) ENSMUST00000155505.1 uc288dxj.1 uc288dxj.2 uc288dxj.1 uc288dxj.2 
ENSMUST00000155508.2 Gm12333 ENSMUST00000155508.2 Gm12333 (from geneSymbol) ENSMUST00000155508.1 uc288adu.1 uc288adu.2 uc288adu.1 uc288adu.2 
ENSMUST00000155534.9 Muc5ac ENSMUST00000155534.9 mucin 5, subtypes A and C, tracheobronchial/gastric (from RefSeq NM_010844.3) E9QAQ8 E9QAQ8_MOUSE ENSMUST00000155534.1 ENSMUST00000155534.2 ENSMUST00000155534.3 ENSMUST00000155534.4 ENSMUST00000155534.5 ENSMUST00000155534.6 ENSMUST00000155534.7 ENSMUST00000155534.8 Muc5ac NM_010844 uc291xgb.1 uc291xgb.2 Lacks conserved residue(s) required for the propagation of feature annotation. protein binding extracellular region extracellular space cytoplasm maintenance of lens transparency phosphatidylinositol-mediated signaling mucus layer uc291xgb.1 uc291xgb.2 
ENSMUST00000155540.4 5730437C11Rik ENSMUST00000155540.4 5730437C11Rik (from geneSymbol) AK017623 ENSMUST00000155540.1 ENSMUST00000155540.2 ENSMUST00000155540.3 uc290hzj.1 uc290hzj.2 uc290hzj.3 uc290hzj.1 uc290hzj.2 uc290hzj.3 
ENSMUST00000155550.3 Gm16230 ENSMUST00000155550.3 Gm16230 (from geneSymbol) ENSMUST00000155550.1 ENSMUST00000155550.2 uc287vpd.1 uc287vpd.2 uc287vpd.3 uc287vpd.1 uc287vpd.2 uc287vpd.3 
ENSMUST00000155551.8 Dcaf10 ENSMUST00000155551.8 DDB1 and CUL4 associated factor 10 (from RefSeq NM_153167.2) A2AKB9 A2AKV8 DCA10_MOUSE ENSMUST00000155551.1 ENSMUST00000155551.2 ENSMUST00000155551.3 ENSMUST00000155551.4 ENSMUST00000155551.5 ENSMUST00000155551.6 ENSMUST00000155551.7 NM_153167 Q3TNI7 Q5U4G6 Q8BHQ2 Q8BHS1 Q8BHX4 Q8K3A5 Wdr32 uc008ssn.1 uc008ssn.2 uc008ssn.3 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Protein modification; protein ubiquitination. Interacts with DDB1. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=A2AKB9-1; Sequence=Displayed; Name=2; IsoId=A2AKB9-2; Sequence=VSP_028516; Name=3; IsoId=A2AKB9-3; Sequence=VSP_028514; Name=4; IsoId=A2AKB9-4; Sequence=VSP_028515; Belongs to the WD repeat DCAF10 family. Sequence=AAH27317.1; Type=Erroneous initiation; Evidence=; Sequence=AAH85101.1; Type=Erroneous initiation; Evidence=; Sequence=BAC38912.1; Type=Erroneous initiation; Evidence=; Sequence=CAM20443.1; Type=Erroneous gene model prediction; Evidence=; molecular_function biological_process protein ubiquitination Cul4-RING E3 ubiquitin ligase complex uc008ssn.1 uc008ssn.2 uc008ssn.3 
ENSMUST00000155562.2 Sox5os4 ENSMUST00000155562.2 Sox5os4 (from geneSymbol) AK131695 ENSMUST00000155562.1 uc291kde.1 uc291kde.2 uc291kde.1 uc291kde.2 
ENSMUST00000155576.8 Arhgap26 ENSMUST00000155576.8 Rho GTPase activating protein 26, transcript variant 3 (from RefSeq NM_001374831.1) Arhgap26 E9QAQ3 E9QAQ3_MOUSE ENSMUST00000155576.1 ENSMUST00000155576.2 ENSMUST00000155576.3 ENSMUST00000155576.4 ENSMUST00000155576.5 ENSMUST00000155576.6 ENSMUST00000155576.7 NM_001374831 uc289oxm.1 uc289oxm.2 Cell junction, focal adhesion Cytoplasm, cytoskeleton GTPase activator activity signal transduction actin cytoskeleton organization positive regulation of GTPase activity regulation of small GTPase mediated signal transduction uc289oxm.1 uc289oxm.2 
ENSMUST00000155578.2 Gm11817 ENSMUST00000155578.2 Gm11817 (from geneSymbol) AK131756 ENSMUST00000155578.1 uc290lcn.1 uc290lcn.2 uc290lcn.1 uc290lcn.2 
ENSMUST00000155579.8 Sertad4 ENSMUST00000155579.8 SERTA domain containing 4, transcript variant 1 (from RefSeq NM_198247.2) A7DTG3 ENSMUST00000155579.1 ENSMUST00000155579.2 ENSMUST00000155579.3 ENSMUST00000155579.4 ENSMUST00000155579.5 ENSMUST00000155579.6 ENSMUST00000155579.7 NM_198247 Q6PAK2 SRTD4_MOUSE uc007eds.1 uc007eds.2 uc007eds.3 uc007eds.4 Highly expressed in adult epidermal tissues and in digits. Sequence=AAH60251.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component nucleus biological_process uc007eds.1 uc007eds.2 uc007eds.3 uc007eds.4 
ENSMUST00000155588.8 Gm16070 ENSMUST00000155588.8 predicted gene 16070 (from RefSeq NR_130314.1) ENSMUST00000155588.1 ENSMUST00000155588.2 ENSMUST00000155588.3 ENSMUST00000155588.4 ENSMUST00000155588.5 ENSMUST00000155588.6 ENSMUST00000155588.7 NR_130314 uc007akf.1 uc007akf.2 uc007akf.3 uc007akf.1 uc007akf.2 uc007akf.3 
ENSMUST00000155592.8 Tfpt ENSMUST00000155592.8 TCF3 (E2A) fusion partner, transcript variant 2 (from RefSeq NM_023524.3) Amida ENSMUST00000155592.1 ENSMUST00000155592.2 ENSMUST00000155592.3 ENSMUST00000155592.4 ENSMUST00000155592.5 ENSMUST00000155592.6 ENSMUST00000155592.7 NM_023524 Q3U1J1 Q9EP77 TFPT_MOUSE uc009evf.1 uc009evf.2 uc009evf.3 uc009evf.4 Appears to promote apoptosis in a p53/TP53-independent manner. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Interacts with NOL3; translocates NOL3 into the nucleus and negatively regulated TFPT-induced cell death. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3U1J1-1; Sequence=Displayed; Name=2; IsoId=Q3U1J1-2; Sequence=VSP_021243; DNA binding nucleus nucleoplasm cytoplasm DNA repair DNA recombination apoptotic process cellular response to DNA damage stimulus protein kinase binding Ino80 complex nuclear membrane positive regulation of apoptotic process protein heterodimerization activity apoptotic signaling pathway actin filament uc009evf.1 uc009evf.2 uc009evf.3 uc009evf.4 
ENSMUST00000155610.2 Gm15609 ENSMUST00000155610.2 Gm15609 (from geneSymbol) AK043913 ENSMUST00000155610.1 uc289arp.1 uc289arp.2 uc289arp.1 uc289arp.2 
ENSMUST00000155633.8 Clec16a ENSMUST00000155633.8 C-type lectin domain family 16, member A, transcript variant 2 (from RefSeq NM_001204229.1) A6X932 B2RSL3 CL16A_MOUSE Clec16a ENSMUST00000155633.1 ENSMUST00000155633.2 ENSMUST00000155633.3 ENSMUST00000155633.4 ENSMUST00000155633.5 ENSMUST00000155633.6 ENSMUST00000155633.7 Kiaa0350 NM_001204229 Q3TCF2 Q3U0F5 Q3U2F6 Q80U30 Q8CEQ8 uc007yea.1 uc007yea.2 uc007yea.3 uc007yea.4 Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. Interacts with RNF41/NRDP1. Q80U30-2; Q8BH75: Rnf41; NbExp=3; IntAct=EBI-9696757, EBI-7059583; Endosome membrane ; Peripheral membrane protein Lysosome membrane ; Peripheral membrane protein Note=Associates with the endolysosome membrane. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q80U30-1; Sequence=Displayed; Name=2; IsoId=Q80U30-2; Sequence=VSP_022752; Name=3; IsoId=Q80U30-3; Sequence=VSP_022752, VSP_022753, VSP_022754, VSP_022757; Name=4; IsoId=Q80U30-4; Sequence=VSP_022752, VSP_022753, VSP_022755, VSP_022756; Name=5; IsoId=Q80U30-5; Sequence=VSP_022751, VSP_022758, VSP_022759; Ubiquitously expressed. Expressed in pancreatic islets. Mice with pancreatic specific deletion of Clec16a are significantly hyperglycemic and have reduced basal and blunted insulin release after glucose administration. Mutant mice have normal islet architecture and beta cell mass, but beta cells show accumulation of vacuolated structures and unhealthy mitochondria (rounded mitochondria with disordered and amorphous structure). Not associated with immune infiltration and insulitis. Belongs to the CLEC16A/gop-1 family. Sequence=BAC65537.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding lysosome lysosomal membrane endosome Golgi apparatus cytosol autophagy endosome to lysosome transport cellular response to starvation endosome membrane membrane integral component of membrane endosomal transport Rab GTPase binding vesicle negative regulation of proteasomal ubiquitin-dependent protein catabolic process endolysosome membrane negative regulation of autophagosome maturation positive regulation of autophagosome maturation negative regulation of macromitophagy positive regulation of TORC1 signaling negative regulation of macroautophagy by TORC1 signaling late endosome uc007yea.1 uc007yea.2 uc007yea.3 uc007yea.4 
ENSMUST00000155634.8 Slc2a9 ENSMUST00000155634.8 High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules. May have a residual high- affinity, low-capacity glucose and fructose transporter activity. Transports urate at rates 45- to 60-fold faster than glucose. Does not transport galactose. May mediate small uptake of adenine but not of other nucleobases. (from UniProt Q3T9X0) A0A0J9YUW8 AK172234 B7ZNE4 B9EHN5 D3Z1X2 D6REU9 ENSMUST00000155634.1 ENSMUST00000155634.2 ENSMUST00000155634.3 ENSMUST00000155634.4 ENSMUST00000155634.5 ENSMUST00000155634.6 ENSMUST00000155634.7 GTR9_MOUSE Glut9 Q3T9X0 Q5ERC7 Q7TSK9 Q7TSP0 Q8BZR3 Q99JJ2 Slc2a9 uc290vax.1 uc290vax.2 High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules. May have a residual high- affinity, low-capacity glucose and fructose transporter activity. Transports urate at rates 45- to 60-fold faster than glucose. Does not transport galactose. May mediate small uptake of adenine but not of other nucleobases. Reaction=urate(out) = urate(in); Xref=Rhea:RHEA:60368, ChEBI:CHEBI:17775; Evidence=; Kinetic parameters: KM=649 uM for urate ; Basolateral cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=GLUT9a IsoId=Q3T9X0-1; Sequence=Displayed; Name=2; Synonyms=GLUT9b IsoId=Q3T9X0-2; Sequence=VSP_060215; Name=3; Synonyms=GLUT9Sa ; IsoId=Q3T9X0-3; Sequence=VSP_060216; Name=4; Synonyms=GLUT9Sb ; IsoId=Q3T9X0-4; Sequence=VSP_060215, VSP_060216; Highly expressed in the intestine, with high expression in the jejunum and ileum, the segments of the intestine that perform the majority of urate excretion (PubMed:25100214). Isoform 1: Widely expressed (PubMed:16293642). Isoform 1: In kidney, expressed at low levels in proximal tubules (PubMed:19587147). Isoform 2: Primarily expressed in liver and kidney; with specific expression in distal convoluted and connecting tubules of kidney (PubMed:16293642, PubMed:19587147). N-glycosylated. Conditional knockout mice lacking Slc2a9 in enterocytes are born at the expected Mendelian rate; they show no obvious phenotype and are fertile (PubMed:25100214). Mice however develop impaired enterocyte uric acid transport kinetics, hyperuricaemia, hyperuricosuria, spontaneous hypertension, dyslipidaemia and elevated body fat (PubMed:25100214). Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. High-capacity urate transporter that was first described as a fructose and glucose transporter. Also described in the literature as high-affinity and low-capacity glucose and fructose transporter (By similarity). However, another group could not confirm transporter activity for glucose or fructose (By similarity). glucose transmembrane transporter activity plasma membrane urate transmembrane transporter activity urate transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane transmembrane transporter activity urate metabolic process transmembrane transport glucose transmembrane transport fructose transport uc290vax.1 uc290vax.2 
ENSMUST00000155641.2 Gm13997 ENSMUST00000155641.2 Gm13997 (from geneSymbol) ENSMUST00000155641.1 uc289zrs.1 uc289zrs.2 uc289zrs.1 uc289zrs.2 
ENSMUST00000155671.8 Vps29 ENSMUST00000155671.8 VPS29 retromer complex component, transcript variant 5 (from RefSeq NR_152873.1) ENSMUST00000155671.1 ENSMUST00000155671.2 ENSMUST00000155671.3 ENSMUST00000155671.4 ENSMUST00000155671.5 ENSMUST00000155671.6 ENSMUST00000155671.7 NR_152873 Q3UCZ0 Q9D107 Q9QZ88 VPS29_MOUSE uc008zlb.1 uc008zlb.2 uc008zlb.3 Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR- pIgA) (By similarity). Acts also as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha- 5/beta-1 (ITGA5:ITGB1). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 (By similarity). Has no activity towards p-nitrophenylphosphate, p- nitrophenylphosphorylcholine or phosphatidylinositlphosphates or a phosphorylated peptide derived from retromer cargo (in vitro) (PubMed:21629666, PubMed:15965486). Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS) formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35 (PubMed:21040701, PubMed:20875039, PubMed:21920005). The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform (By similarity). The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX- BAR subcomplex to form the SNX27-retromer complex (By similarity). Component of the heterotrimeric retriever complex formed by VPS26C, VPS29 and VPS35L (By similarity). Interacts with VPS35L (By similarity). Interacts with VPS26A, VPS26B, VPS35, ANKRD27 (PubMed:20875039, PubMed:21920005, PubMed:24856514). Interacts with SNX1, SNX2, SNX27, WASHC5 (By similarity). Q9QZ88; Q9EQH3: Vps35; NbExp=5; IntAct=EBI-8334188, EBI-775825; Q9QZ88; Q5T1M5: FKBP15; Xeno; NbExp=7; IntAct=EBI-8334188, EBI-5235934; Q9QZ88; Q92609: TBC1D5; Xeno; NbExp=5; IntAct=EBI-8334188, EBI-742381; Q9QZ88; Q96QK1: VPS35; Xeno; NbExp=7; IntAct=EBI-8334188, EBI-1054634; Q9QZ88-1; Q9EQH3: Vps35; NbExp=3; IntAct=EBI-15553808, EBI-775825; Cytoplasm Membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QZ88-1; Sequence=Displayed; Name=2; IsoId=Q9QZ88-2; Sequence=VSP_004074; Belongs to the VPS29 family. Was originally believed to be a metal-dependent phosphatase but shown to lack catalytic activity; can bind metals (Zn(2+) and Mn(2+)) with very low affinity suggesting that metal binding is not required for its function. protein binding cytoplasm endosome cytosol intracellular protein transport Golgi to vacuole transport endosome membrane protein transport membrane retromer complex retromer, cargo-selective complex endocytic recycling retrograde transport, endosome to Golgi intracellular membrane-bounded organelle metal ion binding retrograde transport, endosome to plasma membrane uc008zlb.1 uc008zlb.2 uc008zlb.3 
ENSMUST00000155674.2 Gm14286 ENSMUST00000155674.2 Gm14286 (from geneSymbol) ENSMUST00000155674.1 KY467912 uc057len.1 uc057len.2 uc057len.1 uc057len.2 
ENSMUST00000155722.2 Gm13619 ENSMUST00000155722.2 Gm13619 (from geneSymbol) AK034315 ENSMUST00000155722.1 uc289wnc.1 uc289wnc.2 uc289wnc.1 uc289wnc.2 
ENSMUST00000155737.8 Gnb4 ENSMUST00000155737.8 guanine nucleotide binding protein (G protein), beta 4, transcript variant 1 (from RefSeq NM_013531.6) ENSMUST00000155737.1 ENSMUST00000155737.2 ENSMUST00000155737.3 ENSMUST00000155737.4 ENSMUST00000155737.5 ENSMUST00000155737.6 ENSMUST00000155737.7 GBB4_MOUSE NM_013531 P29387 Q3TJJ1 Q8R475 Q9JHX8 uc008owl.1 uc008owl.2 uc008owl.3 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units, alpha, beta and gamma. Belongs to the WD repeat G protein beta family. GTPase activity heterotrimeric G-protein complex signal transduction G-protein coupled receptor signaling pathway myelin sheath cell body macromolecular complex binding uc008owl.1 uc008owl.2 uc008owl.3 
ENSMUST00000155786.2 BC046401 ENSMUST00000155786.2 BC046401 (from geneSymbol) ENSMUST00000155786.1 uc290cpd.1 uc290cpd.2 uc290cpd.1 uc290cpd.2 
ENSMUST00000155802.9 Cd84 ENSMUST00000155802.9 CD84 antigen, transcript variant 1 (from RefSeq NM_013489.4) A0A0R4J0K5 A0A0R4J0K5_MOUSE Cd84 ENSMUST00000155802.1 ENSMUST00000155802.2 ENSMUST00000155802.3 ENSMUST00000155802.4 ENSMUST00000155802.5 ENSMUST00000155802.6 ENSMUST00000155802.7 ENSMUST00000155802.8 NM_013489 uc007dpe.1 uc007dpe.2 uc007dpe.3 membrane integral component of membrane negative regulation of granulocyte macrophage colony-stimulating factor production negative regulation of interleukin-18 production negative regulation of mast cell activation identical protein binding negative regulation of mast cell degranulation regulation of store-operated calcium entry uc007dpe.1 uc007dpe.2 uc007dpe.3 
ENSMUST00000155812.2 Tomm6os ENSMUST00000155812.2 translocase of outer mitochondrial membrane 6, opposite strand (from RefSeq NR_045945.1) ENSMUST00000155812.1 NR_045945 uc029tig.1 uc029tig.2 uc029tig.3 uc029tig.1 uc029tig.2 uc029tig.3 
ENSMUST00000155816.8 Snhg3 ENSMUST00000155816.8 Snhg3 (from geneSymbol) BC100513 ENSMUST00000155816.1 ENSMUST00000155816.2 ENSMUST00000155816.3 ENSMUST00000155816.4 ENSMUST00000155816.5 ENSMUST00000155816.6 ENSMUST00000155816.7 uc290qlg.1 uc290qlg.2 uc290qlg.1 uc290qlg.2 
ENSMUST00000155822.2 Gm11413 ENSMUST00000155822.2 predicted gene 11413 (from RefSeq NR_045450.1) ENSMUST00000155822.1 NR_045450 uc029uwo.1 uc029uwo.2 uc029uwo.1 uc029uwo.2 
ENSMUST00000155845.2 Ube4bos3 ENSMUST00000155845.2 ubiquitination factor E4B, opposite strand 3 (from RefSeq NR_131918.1) ENSMUST00000155845.1 NR_131918 uc008vwe.1 uc008vwe.2 uc008vwe.3 uc008vwe.4 uc008vwe.1 uc008vwe.2 uc008vwe.3 uc008vwe.4 
ENSMUST00000155864.4 Gm15984 ENSMUST00000155864.4 Gm15984 (from geneSymbol) AK040684 ENSMUST00000155864.1 ENSMUST00000155864.2 ENSMUST00000155864.3 uc290wlb.1 uc290wlb.2 uc290wlb.3 uc290wlb.1 uc290wlb.2 uc290wlb.3 
ENSMUST00000155877.2 Atxn7l1os1 ENSMUST00000155877.2 Atxn7l1os1 (from geneSymbol) AK139740 ENSMUST00000155877.1 uc288fwg.1 uc288fwg.2 uc288fwg.1 uc288fwg.2 
ENSMUST00000155885.3 Gm14146 ENSMUST00000155885.3 Gm14146 (from geneSymbol) ENSMUST00000155885.1 ENSMUST00000155885.2 uc290bhu.1 uc290bhu.2 uc290bhu.3 uc290bhu.1 uc290bhu.2 uc290bhu.3 
ENSMUST00000155900.2 Gm15713 ENSMUST00000155900.2 predicted gene 15713 (from RefSeq NR_046026.1) ENSMUST00000155900.1 NR_046026 uc029sxh.1 uc029sxh.2 uc029sxh.1 uc029sxh.2 
ENSMUST00000155901.8 Cnot6l ENSMUST00000155901.8 CCR4-NOT transcription complex, subunit 6-like, transcript variant 1 (from RefSeq NM_144910.2) CNO6L_MOUSE ENSMUST00000155901.1 ENSMUST00000155901.2 ENSMUST00000155901.3 ENSMUST00000155901.4 ENSMUST00000155901.5 ENSMUST00000155901.6 ENSMUST00000155901.7 NM_144910 Q3U9M0 Q8C0P4 Q8VEG6 uc008yfg.1 uc008yfg.2 uc008yfg.3 Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence (By similarity). Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions, but the ions interact each with only 1 or 2 residues. ; Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8 (By similarity). Interacts with CNOT1, CNOT3, CNOT7, CNOT8 and CNOT9 (By similarity). Interacts with TOB1 (By similarity). Interacts with NANOS2 (PubMed:20133598). Interacts with ZFP36 (PubMed:21078877). Interacts with ZFP36L2 (By similarity). Interacts with RBM46 (PubMed:36001654). Q8VEG6; Q60809: Cnot7; NbExp=2; IntAct=EBI-2104661, EBI-2104739; Cytoplasm Nucleus Note=Predominantly cytoplasmic. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VEG6-1; Sequence=Displayed; Name=2; IsoId=Q8VEG6-2; Sequence=VSP_030324; Name=3; IsoId=Q8VEG6-3; Sequence=VSP_030324, VSP_030325, VSP_030326; Expressed in embryonic stem (ES) cells. Belongs to the CCR4/nocturin family. Sequence=BAC26790.1; Type=Frameshift; Evidence=; 3'-5'-exoribonuclease activity nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA poly(A) tail shortening nuclease activity exonuclease activity poly(A)-specific ribonuclease activity protein binding nucleus cytoplasm cytosol mRNA processing regulation of translation positive regulation of cell proliferation positive regulation of cytoplasmic mRNA processing body assembly hydrolase activity CCR4-NOT complex gene silencing by RNA metal ion binding mRNA destabilization nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic uc008yfg.1 uc008yfg.2 uc008yfg.3 
ENSMUST00000155912.2 4930511O05Rik ENSMUST00000155912.2 4930511O05Rik (from geneSymbol) AK015765 ENSMUST00000155912.1 uc288lqn.1 uc288lqn.2 uc288lqn.1 uc288lqn.2 
ENSMUST00000155922.2 Hoxaas2 ENSMUST00000155922.2 Hoxa cluster antisense RNA 2 (from RefSeq NR_131182.1) ENSMUST00000155922.1 NR_131182 uc057adg.1 uc057adg.2 uc057adg.3 uc057adg.4 uc057adg.1 uc057adg.2 uc057adg.3 uc057adg.4 
ENSMUST00000155949.2 6530402F18Rik ENSMUST00000155949.2 RIKEN cDNA 6530402F18 gene (from RefSeq NR_029460.1) ENSMUST00000155949.1 NR_029460 uc289umq.1 uc289umq.2 uc289umq.1 uc289umq.2 
ENSMUST00000155954.3 B230217C12Rik ENSMUST00000155954.3 B230217C12Rik (from geneSymbol) A0A1B0GR59 A0A1B0GR59_MOUSE AK081899 B230217C12Rik ENSMUST00000155954.1 ENSMUST00000155954.2 uc007ley.1 uc007ley.2 uc007ley.3 molecular_function cellular_component biological_process membrane integral component of membrane uc007ley.1 uc007ley.2 uc007ley.3 
ENSMUST00000155976.2 Gm15614 ENSMUST00000155976.2 predicted gene 15614 (from RefSeq NR_168094.1) ENSMUST00000155976.1 NR_168094 uc290ukf.1 uc290ukf.2 uc290ukf.1 uc290ukf.2 
ENSMUST00000155982.3 Gm16143 ENSMUST00000155982.3 predicted gene 16143 (from RefSeq NR_152619.1) ENSMUST00000155982.1 ENSMUST00000155982.2 NR_152619 uc287rsq.1 uc287rsq.2 uc287rsq.3 uc287rsq.1 uc287rsq.2 uc287rsq.3 
ENSMUST00000155987.2 Gm11640 ENSMUST00000155987.2 Gm11640 (from geneSymbol) ENSMUST00000155987.1 uc288cxo.1 uc288cxo.2 uc288cxo.1 uc288cxo.2 
ENSMUST00000155992.2 Gm16081 ENSMUST00000155992.2 Gm16081 (from geneSymbol) ENSMUST00000155992.1 uc287lml.1 uc287lml.2 uc287lml.1 uc287lml.2 
ENSMUST00000155998.2 Ankfy1 ENSMUST00000155998.2 ankyrin repeat and FYVE domain containing 1 (from RefSeq NM_009671.5) ANFY1_MOUSE Ankhzn B1ATS3 ENSMUST00000155998.1 Kiaa1255 NM_009671 O54807 Q80TG6 Q80UH8 Q810B6 uc007jzh.1 uc007jzh.2 uc007jzh.3 Proposed effector of Rab5. Binds to phosphatidylinositol 3- phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to- Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport (By similarity). Involved in macropinocytosis; the function is dependent on Rab5-GTP. Interacts with RAB5A (in GTP-bound form). Interacts with RHOD (independent of GTP-loaded status). Interacts with EHD1. Interacts with VPS26A; the interaction is independent of EHD1 and is indicative for an association with the cargo recognition subcomplex of the retromer complex. Cytoplasm Endosome membrane ; Peripheral membrane protein Cytoplasmic vesicle Note=Also associated with endosomal membranes. Localizes to macropinosomes. In kidney proximal tubule cells localizes to vesicle-like structures underneath the apical brush border. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q810B6-1; Sequence=Displayed; Name=2; IsoId=Q810B6-2; Sequence=VSP_007917, VSP_007918; Expressed in kidney proximal tubule epithelial cells; at protein level. cytoplasm endosome early endosome cytosol endocytosis endosome membrane membrane endosomal transport Rab GTPase binding retromer complex cytoplasmic vesicle endosomal vesicle fusion retrograde transport, endosome to Golgi intracellular membrane-bounded organelle macropinosome metal ion binding positive regulation of pinocytosis Golgi to lysosome transport phosphatidylinositol phosphate binding uc007jzh.1 uc007jzh.2 uc007jzh.3 
ENSMUST00000156011.2 Gm15940 ENSMUST00000156011.2 Gm15940 (from geneSymbol) ENSMUST00000156011.1 uc288xrp.1 uc288xrp.2 uc288xrp.1 uc288xrp.2 
ENSMUST00000156018.4 1700031F10Rik ENSMUST00000156018.4 1700031F10Rik (from geneSymbol) BC099573 ENSMUST00000156018.1 ENSMUST00000156018.2 ENSMUST00000156018.3 uc009cvf.1 uc009cvf.2 uc009cvf.3 uc009cvf.4 uc009cvf.5 uc009cvf.1 uc009cvf.2 uc009cvf.3 uc009cvf.4 uc009cvf.5 
ENSMUST00000156020.3 AA645442 ENSMUST00000156020.3 AA645442 (from geneSymbol) ENSMUST00000156020.1 ENSMUST00000156020.2 uc289uiv.1 uc289uiv.2 uc289uiv.3 uc289uiv.1 uc289uiv.2 uc289uiv.3 
ENSMUST00000156081.2 Gm12840 ENSMUST00000156081.2 Gm12840 (from geneSymbol) ENSMUST00000156081.1 uc290pej.1 uc290pej.2 uc290pej.1 uc290pej.2 
ENSMUST00000156099.2 Gm13568 ENSMUST00000156099.2 Gm13568 (from geneSymbol) ENSMUST00000156099.1 uc289uet.1 uc289uet.2 uc289uet.1 uc289uet.2 
ENSMUST00000156144.2 Gm12718 ENSMUST00000156144.2 predicted gene 12718 (from RefSeq NR_040673.1) ENSMUST00000156144.1 NR_040673 uc008txr.1 uc008txr.2 uc008txr.3 uc008txr.1 uc008txr.2 uc008txr.3 
ENSMUST00000156149.8 Gm15892 ENSMUST00000156149.8 Gm15892 (from geneSymbol) AK040276 ENSMUST00000156149.1 ENSMUST00000156149.2 ENSMUST00000156149.3 ENSMUST00000156149.4 ENSMUST00000156149.5 ENSMUST00000156149.6 ENSMUST00000156149.7 uc007kve.1 uc007kve.2 uc007kve.1 uc007kve.2 
ENSMUST00000156159.4 Sptbn5 ENSMUST00000156159.4 spectrin beta, non-erythrocytic 5 (from RefSeq NM_001370938.1) A0A571BF02 A0A571BF02_MOUSE ENSMUST00000156159.1 ENSMUST00000156159.2 ENSMUST00000156159.3 NM_001370938 Sptbn5 uc289zrk.1 uc289zrk.2 uc289zrk.3 uc289zrk.1 uc289zrk.2 uc289zrk.3 
ENSMUST00000156166.8 Agbl1 ENSMUST00000156166.8 ATP/GTP binding protein-like 1 (from RefSeq NM_001199224.1) Agbl1 D3Z1M2 D3Z1M2_MOUSE ENSMUST00000156166.1 ENSMUST00000156166.2 ENSMUST00000156166.3 ENSMUST00000156166.4 ENSMUST00000156166.5 ENSMUST00000156166.6 ENSMUST00000156166.7 NM_001199224 uc012fnc.1 uc012fnc.2 Reaction=(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L- glutamate; Xref=Rhea:RHEA:60004, Rhea:RHEA-COMP:15519, Rhea:RHEA- COMP:15675, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:143623; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60005; Evidence=; Reaction=C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L- glutamate; Xref=Rhea:RHEA:63792, Rhea:RHEA-COMP:16435, Rhea:RHEA- COMP:16436, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:149555, ChEBI:CHEBI:149556; EC=3.4.17.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63793; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Cytoplasm, cytosol Belongs to the peptidase M14 family. metallocarboxypeptidase activity proteolysis zinc ion binding uc012fnc.1 uc012fnc.2 
ENSMUST00000156169.2 Gm14507 ENSMUST00000156169.2 Gm14507 (from geneSymbol) ENSMUST00000156169.1 uc290yws.1 uc290yws.2 uc290yws.1 uc290yws.2 
ENSMUST00000156187.8 Efcab6 ENSMUST00000156187.8 EF-hand calcium binding domain 6, transcript variant 1 (from RefSeq NM_029946.5) A6PW10 A6PW11 A6PW12 Djbp EFCB6_MOUSE ENSMUST00000156187.1 ENSMUST00000156187.2 ENSMUST00000156187.3 ENSMUST00000156187.4 ENSMUST00000156187.5 ENSMUST00000156187.6 ENSMUST00000156187.7 Kiaa1672 NM_029946 Q5DTV8 Q6P1E8 Q6PGK8 Q9D2D8 uc007xbr.1 uc007xbr.2 Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Binds PARK7. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR (By similarity). Nucleus Cytoplasm, cytoskeleton, cilium axoneme Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P1E8-1; Sequence=Displayed; Name=2; IsoId=Q6P1E8-3; Sequence=VSP_019814; Name=3; IsoId=Q6P1E8-4; Sequence=VSP_029427, VSP_029428; Sequence=AAH56955.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH65111.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; calcium ion binding nucleus nucleoplasm biological_process metal ion binding uc007xbr.1 uc007xbr.2 
ENSMUST00000156203.8 Uggt2 ENSMUST00000156203.8 UDP-glucose glycoprotein glucosyltransferase 2 (from RefSeq NM_001081252.2) E9Q4X2 E9Q4X2_MOUSE ENSMUST00000156203.1 ENSMUST00000156203.2 ENSMUST00000156203.3 ENSMUST00000156203.4 ENSMUST00000156203.5 ENSMUST00000156203.6 ENSMUST00000156203.7 NM_001081252 Uggt2 uc007uzj.1 uc007uzj.2 uc007uzj.3 uc007uzj.4 Reaction=N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man- (1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)- alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D- GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = H(+) + N(4)- (alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- (1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:61304, Rhea:RHEA-COMP:14356, Rhea:RHEA-COMP:14357, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885, ChEBI:CHEBI:59080, ChEBI:CHEBI:139493; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Protein modification; protein glycosylation. Endoplasmic reticulum lumen Belongs to the glycosyltransferase 8 family. UDP-glucose:glycoprotein glucosyltransferase activity endoplasmic reticulum protein glycosylation protein N-linked glycosylation via asparagine macromolecular complex unfolded protein binding ER-associated misfolded protein catabolic process UDP-glucosylation uc007uzj.1 uc007uzj.2 uc007uzj.3 uc007uzj.4 
ENSMUST00000156205.2 Gm11615 ENSMUST00000156205.2 Gm11615 (from geneSymbol) BC042721 ENSMUST00000156205.1 uc288cia.1 uc288cia.2 uc288cia.1 uc288cia.2 
ENSMUST00000156209.2 Gm13790 ENSMUST00000156209.2 Gm13790 (from geneSymbol) ENSMUST00000156209.1 uc290yoz.1 uc290yoz.2 uc290yoz.1 uc290yoz.2 
ENSMUST00000156224.2 Gm16172 ENSMUST00000156224.2 Gm16172 (from geneSymbol) ENSMUST00000156224.1 uc289lje.1 uc289lje.2 uc289lje.1 uc289lje.2 
ENSMUST00000156236.2 Gm15286 ENSMUST00000156236.2 Gm15286 (from geneSymbol) ENSMUST00000156236.1 uc288pxl.1 uc288pxl.2 uc288pxl.1 uc288pxl.2 
ENSMUST00000156242.2 Gm10785 ENSMUST00000156242.2 predicted gene 10785 (from RefSeq NR_040389.1) ENSMUST00000156242.1 NR_040389 uc007zye.1 uc007zye.2 uc007zye.3 uc007zye.4 uc007zye.1 uc007zye.2 uc007zye.3 uc007zye.4 
ENSMUST00000156249.2 Ubc ENSMUST00000156249.2 ubiquitin C (from RefSeq NM_019639.4) E9QKI0 ENSMUST00000156249.1 NM_019639 P02248 P02249 P02250 P0CG50 P62991 Q29120 Q62317 Q64223 Q8VCH1 Q91887 Q91888 Q9CXY4 Q9CZM0 Q9D1R5 Q9D8D9 Q9ET23 Q9ET24 Q9Z0H9 UBC_MOUSE uc012edr.1 uc012edr.2 uc012edr.3 [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell- cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. [Ubiquitin]: Cytoplasm Nucleus Mitochondrion outer membrane ; Peripheral membrane protein [Ubiquitin]: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1- mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30. [Ubiquitin]: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones. Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains. Belongs to the ubiquitin family. protease binding protein binding nucleus nucleoplasm cytoplasm cytosol protein ubiquitination modification-dependent protein catabolic process protein tag ubiquitin protein ligase binding myelin sheath uc012edr.1 uc012edr.2 uc012edr.3 
ENSMUST00000156275.2 4933427J07Rik ENSMUST00000156275.2 4933427J07Rik (from geneSymbol) AK016956 ENSMUST00000156275.1 uc290aiw.1 uc290aiw.2 uc290aiw.1 uc290aiw.2 
ENSMUST00000156290.9 Ttc28 ENSMUST00000156290.9 tetratricopeptide repeat domain 28 (from RefSeq NM_001267622.1) ENSMUST00000156290.1 ENSMUST00000156290.2 ENSMUST00000156290.3 ENSMUST00000156290.4 ENSMUST00000156290.5 ENSMUST00000156290.6 ENSMUST00000156290.7 ENSMUST00000156290.8 J3QM46 J3QQ36 Kiaa1043 NM_001267622 Q6P9J6 Q80TL5 Q80XJ3 Q8BV10 Q8C0F2 TTC28_MOUSE Tprbk uc033ild.1 uc033ild.2 uc033ild.3 During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. Essential for the formation and integrity of the midbody. Max play a critical role in the progress of mitosis and cytokinesis during cell cycle (By similarity). Interacts with AURKB. Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Midbody Note=At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity). Expressed in embryos at all stages examined. In adult tissues, detected in heart and at low levels in kidney and testis. Sequence=AAH46779.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH60735.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC65709.2; Type=Miscellaneous discrepancy; Note=Several sequencing errors and erroneous CDS prediction.; Evidence=; spindle pole cytoplasm centrosome microtubule organizing center spindle cytoskeleton cell cycle regulation of mitotic cell cycle kinase binding midbody cell division mitotic spindle mitotic spindle pole mitotic spindle midzone uc033ild.1 uc033ild.2 uc033ild.3 
ENSMUST00000156291.2 Fen1 ENSMUST00000156291.2 flap structure specific endonuclease 1, transcript variant 1 (from RefSeq NM_007999.6) ENSMUST00000156291.1 Fen1 NM_007999 Q91Z50 Q91Z50_MOUSE uc008gph.1 uc008gph.2 uc008gph.3 uc008gph.4 Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding. Nucleus, nucleolus cleus, nucleoplasm Mitochondrion Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage. Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily. magnesium ion binding nuclear chromosome, telomeric region DNA binding catalytic activity nuclease activity endonuclease activity RNA-DNA hybrid ribonuclease activity exonuclease activity nucleus nucleoplasm nucleolus mitochondrion DNA replication DNA repair base-excision repair cellular response to DNA damage stimulus memory 5'-3' exonuclease activity hydrolase activity hydrolase activity, acting on ester bonds 5'-flap endonuclease activity macromolecular complex DNA replication, removal of RNA primer positive regulation of sister chromatid cohesion metal ion binding flap endonuclease activity nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc008gph.1 uc008gph.2 uc008gph.3 uc008gph.4 
ENSMUST00000156293.8 BC018473 ENSMUST00000156293.8 cDNA sequence BC018473 (from RefSeq NR_003364.1) ENSMUST00000156293.1 ENSMUST00000156293.2 ENSMUST00000156293.3 ENSMUST00000156293.4 ENSMUST00000156293.5 ENSMUST00000156293.6 ENSMUST00000156293.7 NR_003364 uc007mmb.1 uc007mmb.2 uc007mmb.3 uc007mmb.1 uc007mmb.2 uc007mmb.3 
ENSMUST00000156297.2 Nron ENSMUST00000156297.2 Nron (from geneSymbol) AK042215 ENSMUST00000156297.1 uc029tww.1 uc029tww.2 uc029tww.1 uc029tww.2 
ENSMUST00000156311.2 Gm12484 ENSMUST00000156311.2 Gm12484 (from geneSymbol) ENSMUST00000156311.1 uc290muh.1 uc290muh.2 uc290muh.1 uc290muh.2 
ENSMUST00000156345.2 Gm14123 ENSMUST00000156345.2 Gm14123 (from geneSymbol) AK076437 ENSMUST00000156345.1 uc290bfu.1 uc290bfu.2 uc290bfu.1 uc290bfu.2 
ENSMUST00000156364.3 Lyzl4os ENSMUST00000156364.3 lysozyme-like 4, opposite strand (from RefSeq NR_040740.1) ENSMUST00000156364.1 ENSMUST00000156364.2 NR_040740 uc009sdk.1 uc009sdk.2 uc009sdk.3 uc009sdk.4 uc009sdk.1 uc009sdk.2 uc009sdk.3 uc009sdk.4 
ENSMUST00000156380.4 Pet100 ENSMUST00000156380.4 PET100 homolog (from RefSeq NM_001195244.1) ENSMUST00000156380.1 ENSMUST00000156380.2 ENSMUST00000156380.3 NM_001195244 P0DJE0 PT100_MOUSE uc009krz.1 uc009krz.2 uc009krz.3 Plays a role in mitochondrial complex IV assembly. Interacts with COX7A2. Membrane ; Single-pass membrane protein Mitochondrion Mitochondrion inner membrane Belongs to the PET100 family. mitochondrion membrane integral component of membrane integral component of mitochondrial inner membrane mitochondrial respiratory chain complex IV assembly unfolded protein binding uc009krz.1 uc009krz.2 uc009krz.3 
ENSMUST00000156384.4 Cylc2 ENSMUST00000156384.4 cylicin, basic protein of sperm head cytoskeleton 2, transcript variant 2 (from RefSeq NM_001427184.1) A0A571BEE2 A0A571BEE2_MOUSE Cylc2 ENSMUST00000156384.1 ENSMUST00000156384.2 ENSMUST00000156384.3 NM_001427184 uc290mrw.1 uc290mrw.2 uc290mrw.3 uc290mrw.1 uc290mrw.2 uc290mrw.3 
ENSMUST00000156392.8 Tex30 ENSMUST00000156392.8 Sequence=AAI16882.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI19033.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; (from UniProt Q3TUU5) AK160565 ENSMUST00000156392.1 ENSMUST00000156392.2 ENSMUST00000156392.3 ENSMUST00000156392.4 ENSMUST00000156392.5 ENSMUST00000156392.6 ENSMUST00000156392.7 Q3TUU5 Q4KKZ6 Q9D9T9 TEX30_MOUSE uc287htj.1 uc287htj.2 Sequence=AAI16882.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI19033.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleus biological_process hydrolase activity uc287htj.1 uc287htj.2 
ENSMUST00000156395.3 Unc45bos ENSMUST00000156395.3 unc-45 myosin chaperone B, opposite strand (from RefSeq NR_167696.1) ENSMUST00000156395.1 ENSMUST00000156395.2 NR_167696 uc288auy.1 uc288auy.2 uc288auy.3 uc288auy.1 uc288auy.2 uc288auy.3 
ENSMUST00000156400.9 Naa12 ENSMUST00000156400.9 Reaction=acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-alanyl-[protein]; Xref=Rhea:RHEA:50500, Rhea:RHEA-COMP:12701, Rhea:RHEA-COMP:12702, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64718, ChEBI:CHEBI:83683; EC=2.3.1.255; Evidence=; (from UniProt Q9CQX6) AK010599 ENSMUST00000156400.1 ENSMUST00000156400.2 ENSMUST00000156400.3 ENSMUST00000156400.4 ENSMUST00000156400.5 ENSMUST00000156400.6 ENSMUST00000156400.7 ENSMUST00000156400.8 Naa12 Q9CQX6 Q9CQX6_MOUSE uc289psv.1 uc289psv.2 uc289psv.3 Reaction=acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-alanyl-[protein]; Xref=Rhea:RHEA:50500, Rhea:RHEA-COMP:12701, Rhea:RHEA-COMP:12702, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64718, ChEBI:CHEBI:83683; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:50512, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:12708, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:65250, ChEBI:CHEBI:133372; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-seryl-[protein]; Xref=Rhea:RHEA:50504, Rhea:RHEA-COMP:12703, Rhea:RHEA-COMP:12704, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64738, ChEBI:CHEBI:83690; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-threonyl-[protein]; Xref=Rhea:RHEA:50516, Rhea:RHEA-COMP:12709, Rhea:RHEA-COMP:12710, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64739, ChEBI:CHEBI:133375; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetyl-L-valyl-[protein]; Xref=Rhea:RHEA:50508, Rhea:RHEA-COMP:12705, Rhea:RHEA-COMP:12706, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64741, ChEBI:CHEBI:133371; EC=2.3.1.255; Evidence=; Reaction=acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N- terminal N(alpha)-acetylglycyl-[protein]; Xref=Rhea:RHEA:50496, Rhea:RHEA-COMP:12666, Rhea:RHEA-COMP:12700, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64723, ChEBI:CHEBI:133369; EC=2.3.1.255; Evidence=; Belongs to the acetyltransferase family. ARD1 subfamily. peptide alpha-N-acetyltransferase activity N-terminal protein amino acid acetylation N-acetyltransferase activity N-terminal peptidyl-serine acetylation N-terminal peptidyl-glutamic acid acetylation NatA complex peptide-serine-N-acetyltransferase activity peptide-glutamate-N-acetyltransferase activity uc289psv.1 uc289psv.2 uc289psv.3 
ENSMUST00000156418.9 A930012O16Rik ENSMUST00000156418.9 A930012O16Rik (from geneSymbol) AK044432 ENSMUST00000156418.1 ENSMUST00000156418.2 ENSMUST00000156418.3 ENSMUST00000156418.4 ENSMUST00000156418.5 ENSMUST00000156418.6 ENSMUST00000156418.7 ENSMUST00000156418.8 uc008jsa.1 uc008jsa.2 uc008jsa.3 uc008jsa.4 uc008jsa.1 uc008jsa.2 uc008jsa.3 uc008jsa.4 
ENSMUST00000156420.9 Gm49378 ENSMUST00000156420.9 Plays an essential role in autophagy. (from UniProt A0A2I3BRG5) A0A2I3BRG5 A0A2I3BRG5_MOUSE BC085150 ENSMUST00000156420.1 ENSMUST00000156420.2 ENSMUST00000156420.3 ENSMUST00000156420.4 ENSMUST00000156420.5 ENSMUST00000156420.6 ENSMUST00000156420.7 ENSMUST00000156420.8 Gm49378 uc288uoy.1 uc288uoy.2 Plays an essential role in autophagy. Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane protein localization to membrane uc288uoy.1 uc288uoy.2 
ENSMUST00000156437.3 Adgrd1 ENSMUST00000156437.3 adhesion G protein-coupled receptor D1, transcript variant 2 (from RefSeq NM_001347486.1) Adgrd1 B2RXV6 B2RXV6_MOUSE ENSMUST00000156437.1 ENSMUST00000156437.2 Gpr133 NM_001347486 uc012edy.1 uc012edy.2 uc012edy.3 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. transmembrane signaling receptor activity G-protein coupled receptor activity cell surface receptor signaling pathway G-protein coupled receptor signaling pathway membrane integral component of membrane uc012edy.1 uc012edy.2 uc012edy.3 
ENSMUST00000156438.2 Gm13115 ENSMUST00000156438.2 Gm13115 (from geneSymbol) ENSMUST00000156438.1 uc290sgb.1 uc290sgb.2 uc290sgb.1 uc290sgb.2 
ENSMUST00000156440.8 Zpr1 ENSMUST00000156440.8 ZPR1 zinc finger (from RefSeq NM_011752.2) ENSMUST00000156440.1 ENSMUST00000156440.2 ENSMUST00000156440.3 ENSMUST00000156440.4 ENSMUST00000156440.5 ENSMUST00000156440.6 ENSMUST00000156440.7 NM_011752 Q62384 ZPR1_MOUSE Zfp259 Znf259 uc009phh.1 uc009phh.2 uc009phh.3 Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression (By similarity). Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Interacts (via C-terminal region) with SMN1 (via C- terminal region); the interaction occurs after treatment with serum (By similarity). Interacts with elongation factor 1-alpha EEF1A1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts (via zinc fingers) with EGFR (via C-terminal cytoplasmic kinase domain); the interaction is negatively regulated in response to epidermal growth factor (EGF) stimulation and EGFR kinase activity. May also bind to the PDGFR receptor. Q62384; P02994: TEF2; Xeno; NbExp=2; IntAct=EBI-11566629, EBI-6314; Nucleus. Cytoplasm. Nucleus, nucleolus. Cytoplasm, perinuclear region Nucleus, gem. Nucleus, Cajal body. Cell projection, axon. Cell projection, growth cone. Note=Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner (By similarity). Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons. Expressed in brain. Expressed in the spinal cord motor neurons (at protein level). Expressed in spleen, liver, muscle, kidney and testis. Expressed in the frontal cortex, cornus ammonis, dentate gyrus of the hippocampus and in Purkinje cells of the cerebellum. Up-regulated by high fat diet. Note=May contribute to the severity of spinal muscular atrophy by increasing spinal motor neurons degeneration. Die during early embryonic development. Embryos show growth delay, failed to form normal trophectoderm and to expand the inner cell mass. Belongs to the ZPR1 family. microtubule cytoskeleton organization inner cell mass cell proliferation trophectodermal cell proliferation protein binding nucleus nucleoplasm nucleolus cytoplasm mRNA processing multicellular organism development zinc ion binding RNA splicing positive regulation of gene expression Cajal body spinal cord development cell differentiation axon growth cone Cajal body organization receptor tyrosine kinase binding translation initiation factor binding regulation of myelination positive regulation of RNA splicing DNA endoreduplication positive regulation of protein import into nucleus cell projection neuronal cell body perikaryon positive regulation of growth metal ion binding perinuclear region of cytoplasm axon development cellular response to epidermal growth factor stimulus positive regulation of transcription involved in G1/S transition of mitotic cell cycle Gemini of coiled bodies apoptotic process involved in development pre-mRNA catabolic process negative regulation of motor neuron apoptotic process uc009phh.1 uc009phh.2 uc009phh.3 
ENSMUST00000156443.3 Sox5os2 ENSMUST00000156443.3 Sox5os2 (from geneSymbol) ENSMUST00000156443.1 ENSMUST00000156443.2 uc291kdb.1 uc291kdb.2 uc291kdb.3 uc291kdb.1 uc291kdb.2 uc291kdb.3 
ENSMUST00000156446.2 Gm16034 ENSMUST00000156446.2 Gm16034 (from geneSymbol) ENSMUST00000156446.1 uc287xpo.1 uc287xpo.2 uc287xpo.1 uc287xpo.2 
ENSMUST00000156467.2 Gm15708 ENSMUST00000156467.2 predicted gene 15708 (from RefSeq NR_040432.1) ENSMUST00000156467.1 NR_040432 uc012ego.1 uc012ego.2 uc012ego.3 uc012ego.4 uc012ego.1 uc012ego.2 uc012ego.3 uc012ego.4 
ENSMUST00000156477.4 Dlx4os ENSMUST00000156477.4 distal-less homeobox 4, opposite strand (from RefSeq NR_040279.1) ENSMUST00000156477.1 ENSMUST00000156477.2 ENSMUST00000156477.3 NR_040279 uc007lab.1 uc007lab.2 uc007lab.3 uc007lab.1 uc007lab.2 uc007lab.3 
ENSMUST00000156481.8 Med28 ENSMUST00000156481.8 mediator complex subunit 28 (from RefSeq NM_025895.4) ENSMUST00000156481.1 ENSMUST00000156481.2 ENSMUST00000156481.3 ENSMUST00000156481.4 ENSMUST00000156481.5 ENSMUST00000156481.6 ENSMUST00000156481.7 Fksg20 MED28_MOUSE NM_025895 Q3U4G7 Q920D3 Q9CQF2 uc012dvz.1 uc012dvz.2 uc012dvz.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Forms a ternary complex with NF2/merlin and GRB2. Binds to actin (By similarity). Nucleus Cytoplasm Membrane Note=May be also cytoplasmic and membrane- associated. Belongs to the Mediator complex subunit 28 family. actin binding protein binding nucleus nucleoplasm cytoplasm cytoskeleton membrane mediator complex stem cell population maintenance cortical actin cytoskeleton negative regulation of smooth muscle cell differentiation uc012dvz.1 uc012dvz.2 uc012dvz.3 
ENSMUST00000156494.2 Gm14812 ENSMUST00000156494.2 predicted gene 14812 (from RefSeq NR_033544.2) ENSMUST00000156494.1 NR_033544 uc012hmo.1 uc012hmo.2 uc012hmo.1 uc012hmo.2 
ENSMUST00000156515.10 Hoxa11os ENSMUST00000156515.10 homeobox A11, opposite strand (from RefSeq NR_015348.2) ENSMUST00000156515.1 ENSMUST00000156515.2 ENSMUST00000156515.3 ENSMUST00000156515.4 ENSMUST00000156515.5 ENSMUST00000156515.6 ENSMUST00000156515.7 ENSMUST00000156515.8 ENSMUST00000156515.9 NR_015348 uc009byo.1 uc009byo.2 uc009byo.3 uc009byo.4 uc009byo.5 uc009byo.1 uc009byo.2 uc009byo.3 uc009byo.4 uc009byo.5 
ENSMUST00000156520.8 Abhd5 ENSMUST00000156520.8 abhydrolase domain containing 5, transcript variant 3 (from RefSeq NR_152865.1) ABHD5_MOUSE Abhd5 ENSMUST00000156520.1 ENSMUST00000156520.2 ENSMUST00000156520.3 ENSMUST00000156520.4 ENSMUST00000156520.5 ENSMUST00000156520.6 ENSMUST00000156520.7 NR_152865 Q9CTY3 Q9DBL9 uc009sew.1 uc009sew.2 uc009sew.3 Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid (PubMed:19801371). Functions preferentially with 1-oleoyl- lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1- stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor (PubMed:19801371). Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (PubMed:19801371). Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (By similarity). Regulates lipid droplet fusion (PubMed:26083785). Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19710; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3- phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74544, ChEBI:CHEBI:74546; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37132; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37143, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74544, ChEBI:CHEBI:74551; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37144; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37147, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:74544, ChEBI:CHEBI:74552; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37148; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn- glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)- eicosatetraenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37443, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74544, ChEBI:CHEBI:74928; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37444; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37451, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:74544, ChEBI:CHEBI:74937; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37452; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:33187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57518, ChEBI:CHEBI:64839; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33188; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37163, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74560, ChEBI:CHEBI:74565; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37164; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn- glycero-3-phosphate = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)- octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37455, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74938, ChEBI:CHEBI:74941; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37456; Evidence=; Acyltransferase activity is inhibited by detergents such as Triton X-100 and 3-[(3- cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS). Acyltransferase activity is inhibited by the presence of magnesium and calcium. Kinetic parameters: KM=4.8 uM for oleoyl-CoA ; KM=18 uM for 1-oleoyl-lysophosphatidic acid ; Vmax=6.1 nmol/min/mg enzyme toward oleoyl-CoA ; Vmax=7.6 nmol/min/mg enzyme toward 1-oleoyl-lysophosphatidic acid ; pH dependence: Optimum pH is 7-8.5. ; Temperature dependence: Preincubation of the enzyme for 10 min at temperatures above 35 degrees Celsius decreases acyltransferase activity subsequently measured at 30 degrees Celsius. Acyltransferase activity is reduced by approximately 60% following 10 min preincubation at47 degrees Celsius. ; Interacts with ADRP (By similarity). Interacts with PLIN. Interacts with and PNPLA2. Interacts with PLIN5; promotes interaction with PNPLA2. Cytoplasm. Lipid droplet Cytoplasm, cytosol Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DBL9-1; Sequence=Displayed; Name=2; IsoId=Q9DBL9-2; Sequence=VSP_015345; Highly expressed in the adipose tissue and testes. Weakly expressed in the liver, muscle, kidney, and heart. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and hypothalamus in brain (at protein level). The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily. 1-acylglycerol-3-phosphate O-acyltransferase activity protein binding cytoplasm lipid particle cytosol lipid metabolic process fatty acid metabolic process phosphatidic acid biosynthetic process phospholipid biosynthetic process negative regulation of sequestering of triglyceride positive regulation of triglyceride catabolic process transferase activity transferase activity, transferring acyl groups cell differentiation lysophosphatidic acid acyltransferase activity positive regulation of lipid catabolic process positive regulation of lipoprotein lipase activity carboxylic ester hydrolase activity lipid homeostasis triglyceride lipase activity uc009sew.1 uc009sew.2 uc009sew.3 
ENSMUST00000156526.2 Gm15226 ENSMUST00000156526.2 Gm15226 (from geneSymbol) AK054361 ENSMUST00000156526.1 uc292rss.1 uc292rss.2 uc292rss.1 uc292rss.2 
ENSMUST00000156541.2 Gm13912 ENSMUST00000156541.2 Gm13912 (from geneSymbol) AK136267 ENSMUST00000156541.1 uc289zce.1 uc289zce.2 uc289zce.1 uc289zce.2 
ENSMUST00000156576.3 Gm11754 ENSMUST00000156576.3 Gm11754 (from geneSymbol) AK149260 ENSMUST00000156576.1 ENSMUST00000156576.2 uc007mpy.1 uc007mpy.2 uc007mpy.3 uc007mpy.4 uc007mpy.1 uc007mpy.2 uc007mpy.3 uc007mpy.4 
ENSMUST00000156585.9 Ldb1 ENSMUST00000156585.9 Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors (PubMed:8918878, PubMed:9192866). May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions (PubMed:8918878, PubMed:9315627, PubMed:9192866, PubMed:16815859, PubMed:18539116). Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1 (PubMed:12150931, PubMed:8876198, PubMed:18539116). Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression (PubMed:8918878). Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (PubMed:9391090). (from UniProt P70662) ENSMUST00000156585.1 ENSMUST00000156585.2 ENSMUST00000156585.3 ENSMUST00000156585.4 ENSMUST00000156585.5 ENSMUST00000156585.6 ENSMUST00000156585.7 ENSMUST00000156585.8 LDB1_MOUSE Nli O55204 P70662 Q1EQX2 Q71V68 U69270 uc289sfd.1 uc289sfd.2 uc289sfd.3 Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors (PubMed:8918878, PubMed:9192866). May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions (PubMed:8918878, PubMed:9315627, PubMed:9192866, PubMed:16815859, PubMed:18539116). Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1 (PubMed:12150931, PubMed:8876198, PubMed:18539116). Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression (PubMed:8918878). Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (PubMed:9391090). Interacts with ESR1 (By similarity). Forms homodimers and heterodimers (PubMed:9315627, PubMed:9468533). Interacts with and activates LHX1/LIM1 (PubMed:8918878, PubMed:9468533). Interacts with the LIM domains of ISL1 and LMO2 (PubMed:12150931, PubMed:12727888). Can assemble in a complex with LMO2 and TAL1/SCL but does not interact with TAL1/SCL directly (PubMed:9391090). Strongly interacts with the LIM2 domain of LMX1A and more weakly with the LIM1 domain (PubMed:9315627). Homodimerization is not required for, and does not effect, LMX1A-binding (PubMed:9315627). Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (PubMed:16407974). Interacts with LHX6 and LHX9 (PubMed:10393337, PubMed:10330499). At neuronal promoters, forms a complex with LHX3 involved in the specification of interneurons, in motor neurons, it is displaced by ISL1 to form a ternary complex in which ISL1 contacts both LHX3 and LDB1 (PubMed:12150931, PubMed:18539116). Interacts with SLK; leading to negatively regulate SLK kinase activity (PubMed:19675209). Interacts with YWHAZ (By similarity). Interacts with PRDM1/BLIMP1 (By similarity). Interacts with LMO4 (PubMed:15343268, PubMed:9860983, PubMed:23353824). Interacts with RLIM/RNF12; the interaction inhibits the ubiquitination of LMO proteins (PubMed:11882901). P70662; O54972: Cbfa2t3; NbExp=2; IntAct=EBI-6272082, EBI-8006703; P70662; P61372: Isl1; NbExp=4; IntAct=EBI-6272082, EBI-7988215; P70662; P50481: Lhx3; NbExp=5; IntAct=EBI-6272082, EBI-7988290; P70662; P22091: Tal1; NbExp=4; IntAct=EBI-6272082, EBI-8006437; P70662; Q60722: Tcf4; NbExp=2; IntAct=EBI-6272082, EBI-310070; Nucleus Note=Colocalizes with SLK at leading edges (PubMed:19675209). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Visvader-a; IsoId=P70662-1; Sequence=Displayed; Name=2; Synonyms=Tran-b; IsoId=P70662-2; Sequence=VSP_027833, VSP_027834, VSP_027835; Name=3; Synonyms=Tran-a; IsoId=P70662-3; Sequence=VSP_027833; Expressed in multiple adult tissues including heart, brain, liver, kidney, testis, lung and muscle, with expression highest in the pituitary gland and skin. Expression in the embryo overlaps that of LIM domain-containing proteins (PubMed:9192866). Expressed widely in the embryo with highest expression in several regions of the brain, and the central nervous system ganglia (PubMed:8918878, PubMed:9391090, PubMed:9192866). Also expressed in fetal liver, lung, kidney, thymus and olfactory epithelium (PubMed:9192866, PubMed:16815859, PubMed:9391090). Expressed in, but not restricted to, the basal compartment of interfollicular epidermis, the developing hair follicles during embryogenesis and, in adult hair, expressed in matrix cells and the outer root sheath (PubMed:9860983). Expressed in both embryonic and adult hemopoietic cells, including the erythroid lineage (PubMed:9391090). The dimerization domain is located in the N-terminus. Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. [Isoform 2]: Due to intron retention. Lacks LIM-binding domain. Lacks ability to activate LIM domain-dependent transcription. Belongs to the LDB family. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery RNA polymerase II activating transcription factor binding enhancer sequence-specific DNA binding gastrulation with mouth forming second hair follicle development chromatin binding transcription cofactor activity protein binding nucleus nucleoplasm transcription factor complex regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development anterior/posterior axis specification epithelial structure maintenance Wnt signaling pathway enzyme binding cerebellum development cerebellar Purkinje cell differentiation cellular component assembly neuron differentiation LIM domain binding regulation of cell migration cell leading edge regulation of DNA-templated transcription, elongation macromolecular complex somatic stem cell population maintenance protein homodimerization activity regulation of kinase activity protein self-association histone H3-K4 acetylation negative regulation of erythrocyte differentiation positive regulation of cell adhesion negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of hemoglobin biosynthetic process mesendoderm development regulation of focal adhesion assembly primitive erythrocyte differentiation head development beta-catenin-TCF complex DNA binding uc289sfd.1 uc289sfd.2 uc289sfd.3 
ENSMUST00000156612.2 Gm10680 ENSMUST00000156612.2 Gm10680 (from geneSymbol) AK143344 ENSMUST00000156612.1 uc009phe.1 uc009phe.2 uc009phe.3 uc009phe.1 uc009phe.2 uc009phe.3 
ENSMUST00000156615.2 2810404F17Rik ENSMUST00000156615.2 2810404F17Rik (from geneSymbol) AK012982 ENSMUST00000156615.1 uc289gla.1 uc289gla.2 uc289gla.1 uc289gla.2 
ENSMUST00000156666.2 Gm16237 ENSMUST00000156666.2 Gm16237 (from geneSymbol) AK043721 ENSMUST00000156666.1 uc292ebx.1 uc292ebx.2 uc292ebx.1 uc292ebx.2 
ENSMUST00000156718.2 Gm14014 ENSMUST00000156718.2 Gm14014 (from geneSymbol) AK051942 ENSMUST00000156718.1 uc289zbl.1 uc289zbl.2 uc289zbl.1 uc289zbl.2 
ENSMUST00000156744.2 Gm7437 ENSMUST00000156744.2 Gm7437 (from geneSymbol) ENSMUST00000156744.1 uc292nps.1 uc292nps.2 uc292nps.1 uc292nps.2 
ENSMUST00000156781.3 E130111B04Rik ENSMUST00000156781.3 E130111B04Rik (from geneSymbol) AK021378 ENSMUST00000156781.1 ENSMUST00000156781.2 uc288cmo.1 uc288cmo.2 uc288cmo.3 uc288cmo.1 uc288cmo.2 uc288cmo.3 
ENSMUST00000156809.2 Gm13938 ENSMUST00000156809.2 Gm13938 (from geneSymbol) ENSMUST00000156809.1 uc289xdt.1 uc289xdt.2 uc289xdt.1 uc289xdt.2 
ENSMUST00000156816.7 Mrpl15 ENSMUST00000156816.7 mitochondrial ribosomal protein L15, transcript variant 1 (from RefSeq NM_001177658.2) ENSMUST00000156816.1 ENSMUST00000156816.2 ENSMUST00000156816.3 ENSMUST00000156816.4 ENSMUST00000156816.5 ENSMUST00000156816.6 NM_001177658 Q3UBN5 Q9CPP5 Q9CPR5 Q9CRH4 RM15_MOUSE uc007aff.1 uc007aff.2 uc007aff.3 uc007aff.4 uc007aff.5 uc007aff.6 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CPR5-1; Sequence=Displayed; Name=2; IsoId=Q9CPR5-2; Sequence=VSP_021370, VSP_021371; Belongs to the universal ribosomal protein uL15 family. Sequence=BAB27054.1; Type=Erroneous initiation; Evidence=; mitochondrial genome maintenance structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation large ribosomal subunit cellular response to leukemia inhibitory factor uc007aff.1 uc007aff.2 uc007aff.3 uc007aff.4 uc007aff.5 uc007aff.6 
ENSMUST00000156823.2 Gm14715 ENSMUST00000156823.2 Gm14715 (from geneSymbol) ENSMUST00000156823.1 uc292pdn.1 uc292pdn.2 uc292pdn.1 uc292pdn.2 
ENSMUST00000156859.3 Hadha ENSMUST00000156859.3 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha (from RefSeq NM_178878.3) ECHA_MOUSE ENSMUST00000156859.1 ENSMUST00000156859.2 NM_178878 Q3TCY3 Q5U5Y5 Q8BMS1 Q8QZU4 uc008wvc.1 uc008wvc.2 uc008wvc.3 Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity. Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity. It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP. Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity. Reaction=a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O; Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318, ChEBI:CHEBI:58856; EC=4.2.1.17; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:16107; Evidence=; Reaction=a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O; Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521, ChEBI:CHEBI:137480; EC=4.2.1.17; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:20726; Evidence=; Reaction=(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O; Xref=Rhea:RHEA:31199, ChEBI:CHEBI:15377, ChEBI:CHEBI:62242, ChEBI:CHEBI:62617; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31201; Evidence=; Reaction=(3S)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O; Xref=Rhea:RHEA:31075, ChEBI:CHEBI:15377, ChEBI:CHEBI:57330, ChEBI:CHEBI:62558; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31077; Evidence=; Reaction=(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O; Xref=Rhea:RHEA:31163, ChEBI:CHEBI:15377, ChEBI:CHEBI:61526, ChEBI:CHEBI:62613; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31165; Evidence=; Reaction=a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) = a long- chain 3-oxo-fatty acyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:52656, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:136757, ChEBI:CHEBI:136758; EC=1.1.1.211; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52657; Evidence=; Reaction=(3S)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:31195, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62617, ChEBI:CHEBI:62619; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31196; Evidence=; Reaction=(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:31187, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62548, ChEBI:CHEBI:62616; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31188; Evidence=; Reaction=(3S)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:31179, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62558, ChEBI:CHEBI:62615; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31180; Evidence=; Reaction=(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl- CoA + H(+) + NADH; Xref=Rhea:RHEA:31167, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62543, ChEBI:CHEBI:62614; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31168; Evidence=; Reaction=(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:31159, ChEBI:CHEBI:15378, ChEBI:CHEBI:57349, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62613; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31160; Evidence=; Reaction=1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'- [1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3- phospho]-glycerol + CoA; Xref=Rhea:RHEA:43680, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:83580, ChEBI:CHEBI:83583; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43681; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)- sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phospho]-glycerol = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn- glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:43676, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:83580, ChEBI:CHEBI:83582; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43677; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z- octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1,2-di- (9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:43672, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:83580, ChEBI:CHEBI:83581; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43673; Evidence=; Lipid metabolism; fatty acid beta-oxidation. Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme (By similarity). Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear (By similarity). The mitochondrial trifunctional enzyme interacts with MTLN (PubMed:29949755). Mitochondrion Mitochondrion inner membrane Note=Protein stability and association with mitochondrion inner membrane do not require HADHB. Acetylation of Lys-569 and Lys-728 is observed in liver mitochondria from fasted mice but not from fed mice. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. fatty-acyl-CoA binding catalytic activity 3-hydroxyacyl-CoA dehydrogenase activity acetyl-CoA C-acyltransferase activity enoyl-CoA hydratase activity mitochondrion mitochondrial inner membrane lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation metabolic process membrane oxidoreductase activity mitochondrial fatty acid beta-oxidation multienzyme complex long-chain-enoyl-CoA hydratase activity long-chain-3-hydroxyacyl-CoA dehydrogenase activity transferase activity lyase activity response to insulin cardiolipin acyl-chain remodeling response to drug mitochondrial nucleoid macromolecular complex binding NAD binding oxidation-reduction process uc008wvc.1 uc008wvc.2 uc008wvc.3 
ENSMUST00000156876.8 Mfsd6 ENSMUST00000156876.8 major facilitator superfamily domain containing 6, transcript variant 1 (from RefSeq NM_133829.3) D3Z183 D3Z183_MOUSE ENSMUST00000156876.1 ENSMUST00000156876.2 ENSMUST00000156876.3 ENSMUST00000156876.4 ENSMUST00000156876.5 ENSMUST00000156876.6 ENSMUST00000156876.7 Mfsd6 NM_133829 uc007ayl.1 uc007ayl.2 uc007ayl.3 uc007ayl.4 uc007ayl.5 uc007ayl.6 Membrane ; Multi- pass membrane protein Belongs to the major facilitator superfamily. MFSD6 family. membrane integral component of membrane uc007ayl.1 uc007ayl.2 uc007ayl.3 uc007ayl.4 uc007ayl.5 uc007ayl.6 
ENSMUST00000156882.2 Gm16170 ENSMUST00000156882.2 predicted gene 16170 (from RefSeq NR_188983.1) ENSMUST00000156882.1 NR_188983 uc287xrl.1 uc287xrl.2 uc287xrl.1 uc287xrl.2 
ENSMUST00000156898.5 Arpc4 ENSMUST00000156898.5 actin related protein 2/3 complex, subunit 4, transcript variant 1 (from RefSeq NM_026552.3) ARPC4_MOUSE Arc20 ENSMUST00000156898.1 ENSMUST00000156898.2 ENSMUST00000156898.3 ENSMUST00000156898.4 NM_026552 O15509 P59999 Q3UWV4 uc009dfs.1 uc009dfs.2 uc009dfs.3 uc009dfs.4 Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Cytoplasm, cytoskeleton Cell projection Nucleus Belongs to the ARPC4 family. actin binding structural constituent of cytoskeleton nucleus cytoplasm cytoskeleton Arp2/3 protein complex actin cytoskeleton enzyme binding actin filament polymerization protein binding, bridging regulation of actin filament polymerization Arp2/3 complex-mediated actin nucleation site of double-strand break cell projection actin filament binding uc009dfs.1 uc009dfs.2 uc009dfs.3 uc009dfs.4 
ENSMUST00000156926.2 Gm16105 ENSMUST00000156926.2 Gm16105 (from geneSymbol) ENSMUST00000156926.1 uc287tjg.1 uc287tjg.2 uc287tjg.1 uc287tjg.2 
ENSMUST00000156950.3 Gm15458 ENSMUST00000156950.3 Gm15458 (from geneSymbol) ENSMUST00000156950.1 ENSMUST00000156950.2 uc289iuq.1 uc289iuq.2 uc289iuq.1 uc289iuq.2 
ENSMUST00000156977.2 4933404K08Rik ENSMUST00000156977.2 RIKEN cDNA 4933404K08 gene (from RefSeq NR_046038.1) ENSMUST00000156977.1 NR_046038 uc029rzh.1 uc029rzh.2 uc029rzh.1 uc029rzh.2 
ENSMUST00000157010.2 Slc36a1os ENSMUST00000157010.2 solute carrier family 36 (proton/amino acid symporter), member 1, opposite strand (from RefSeq NR_046034.1) ENSMUST00000157010.1 NR_046034 uc007izb.1 uc007izb.2 uc007izb.1 uc007izb.2 
ENSMUST00000157011.3 Gm11269 ENSMUST00000157011.3 Gm11269 (from geneSymbol) AK132790 ENSMUST00000157011.1 ENSMUST00000157011.2 uc290nly.1 uc290nly.2 uc290nly.3 uc290nly.1 uc290nly.2 uc290nly.3 
ENSMUST00000157018.3 Gm15895 ENSMUST00000157018.3 Gm15895 (from geneSymbol) ENSMUST00000157018.1 ENSMUST00000157018.2 uc292deu.1 uc292deu.2 uc292deu.3 uc292deu.1 uc292deu.2 uc292deu.3 
ENSMUST00000157020.2 Gm21973 ENSMUST00000157020.2 Gm21973 (from geneSymbol) ENSMUST00000157020.1 F6WEZ7 F6WEZ7_MOUSE Gm21973 M22958 Prlr uc288wyj.1 uc288wyj.2 cytokine receptor activity prolactin receptor activity external side of plasma membrane membrane integral component of membrane peptide hormone binding cytokine binding prolactin signaling pathway receptor complex metal ion binding uc288wyj.1 uc288wyj.2 
ENSMUST00000157040.8 Mest ENSMUST00000157040.8 mesoderm specific transcript, transcript variant 3 (from RefSeq NM_001252293.1) 121a ENSMUST00000157040.1 ENSMUST00000157040.2 ENSMUST00000157040.3 ENSMUST00000157040.4 ENSMUST00000157040.5 ENSMUST00000157040.6 ENSMUST00000157040.7 MEST_MOUSE NM_001252293 Peg1 Q07646 Q792T8 Q8BS88 Q8K463 Q99KT5 uc009bfs.1 uc009bfs.2 uc009bfs.3 uc009bfs.4 Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q07646-1; Sequence=Displayed; Name=2; Synonyms=MEST intronic transcript 1; IsoId=Q07646-2; Sequence=VSP_024534; Expressed in mesodermal tissues. Isoform 1 is exclusively expressed from the paternal allele in all fetal tissues and cell lines examined, whereas isoform 2 is preferentially expressed from the paternal allele in a tissue-type-specific manner. Expressed in the nascent mesoderm of gastrulating embryos. At 7.0 dpc expression detected in both the intraembryonic mesoderm and the extraembryonic mesoderm cells of the amniotic fold. At 8.5 dpc expressed predominantly in the head mesenchyme, allantois, and the mesodermal layer of the amnion, chorion and yolk. In 9.5 dpc embryos highly expressed in the mesenchymal tissues, presomitic paraxial mesoderm, heart and branchial arches. Belongs to the AB hydrolase superfamily. catalytic activity endoplasmic reticulum endoplasmic reticulum membrane regulation of lipid storage membrane integral component of membrane hydrolase activity response to retinoic acid uc009bfs.1 uc009bfs.2 uc009bfs.3 uc009bfs.4 
ENSMUST00000157059.2 Gm13662 ENSMUST00000157059.2 Gm13662 (from geneSymbol) AK144798 ENSMUST00000157059.1 uc008kba.1 uc008kba.2 uc008kba.3 uc008kba.1 uc008kba.2 uc008kba.3 
ENSMUST00000157082.4 Gm22999 ENSMUST00000157082.4 Gm22999 (from geneSymbol) ENSMUST00000157082.1 ENSMUST00000157082.2 ENSMUST00000157082.3 uc292dkp.1 uc292dkp.2 uc292dkp.1 uc292dkp.2 
ENSMUST00000157083.3 Gm23000 ENSMUST00000157083.3 Gm23000 (from geneSymbol) ENSMUST00000157083.1 ENSMUST00000157083.2 uc292ole.1 uc292ole.2 uc292ole.1 uc292ole.2 
ENSMUST00000157087.4 Gm25828 ENSMUST00000157087.4 Gm25828 (from geneSymbol) ENSMUST00000157087.1 ENSMUST00000157087.2 ENSMUST00000157087.3 uc292pts.1 uc292pts.2 uc292pts.1 uc292pts.2 
ENSMUST00000157089.3 Gm25827 ENSMUST00000157089.3 Gm25827 (from geneSymbol) ENSMUST00000157089.1 ENSMUST00000157089.2 uc290onr.1 uc290onr.2 uc290onr.1 uc290onr.2 
ENSMUST00000157090.3 Gm25826 ENSMUST00000157090.3 Gm25826 (from geneSymbol) ENSMUST00000157090.1 ENSMUST00000157090.2 uc289oos.1 uc289oos.2 uc289oos.1 uc289oos.2 
ENSMUST00000157092.3 Gm25824 ENSMUST00000157092.3 Gm25824 (from geneSymbol) ENSMUST00000157092.1 ENSMUST00000157092.2 uc289pss.1 uc289pss.2 uc289pss.1 uc289pss.2 
ENSMUST00000157093.3 Gm22236 ENSMUST00000157093.3 Gm22236 (from geneSymbol) ENSMUST00000157093.1 ENSMUST00000157093.2 uc287uuj.1 uc287uuj.2 uc287uuj.1 uc287uuj.2 
ENSMUST00000157094.3 Gm26464 ENSMUST00000157094.3 Gm26464 (from geneSymbol) ENSMUST00000157094.1 ENSMUST00000157094.2 uc287qvf.1 uc287qvf.2 uc287qvf.1 uc287qvf.2 
ENSMUST00000157095.4 Gm26279 ENSMUST00000157095.4 Gm26279 (from geneSymbol) ENSMUST00000157095.1 ENSMUST00000157095.2 ENSMUST00000157095.3 uc290hkr.1 uc290hkr.2 uc290hkr.1 uc290hkr.2 
ENSMUST00000157097.4 Gm26277 ENSMUST00000157097.4 Gm26277 (from geneSymbol) ENSMUST00000157097.1 ENSMUST00000157097.2 ENSMUST00000157097.3 uc290yew.1 uc290yew.2 uc290yew.1 uc290yew.2 
ENSMUST00000157098.3 Gm26278 ENSMUST00000157098.3 Gm26278 (from geneSymbol) ENSMUST00000157098.1 ENSMUST00000157098.2 uc287uoe.1 uc287uoe.2 uc287uoe.1 uc287uoe.2 
ENSMUST00000157099.3 Gm26276 ENSMUST00000157099.3 Gm26276 (from geneSymbol) ENSMUST00000157099.1 ENSMUST00000157099.2 uc292oll.1 uc292oll.2 uc292oll.1 uc292oll.2 
ENSMUST00000157107.4 Gm24651 ENSMUST00000157107.4 Gm24651 (from geneSymbol) ENSMUST00000157107.1 ENSMUST00000157107.2 ENSMUST00000157107.3 uc289exq.1 uc289exq.2 uc289exq.1 uc289exq.2 
ENSMUST00000157109.3 Gm24646 ENSMUST00000157109.3 Gm24646 (from geneSymbol) ENSMUST00000157109.1 ENSMUST00000157109.2 uc292gwm.1 uc292gwm.2 uc292gwm.1 uc292gwm.2 
ENSMUST00000157111.3 Gm24648 ENSMUST00000157111.3 Gm24648 (from geneSymbol) ENSMUST00000157111.1 ENSMUST00000157111.2 uc289nia.1 uc289nia.2 uc289nia.1 uc289nia.2 
ENSMUST00000157114.3 Gm24644 ENSMUST00000157114.3 Gm24644 (from geneSymbol) ENSMUST00000157114.1 ENSMUST00000157114.2 LF193450 uc289yxj.1 uc289yxj.2 uc289yxj.1 uc289yxj.2 
ENSMUST00000157117.3 Gm25152 ENSMUST00000157117.3 Gm25152 (from geneSymbol) ENSMUST00000157117.1 ENSMUST00000157117.2 uc290eeb.1 uc290eeb.2 uc290eeb.1 uc290eeb.2 
ENSMUST00000157121.4 Gm25150 ENSMUST00000157121.4 Gm25150 (from geneSymbol) ENSMUST00000157121.1 ENSMUST00000157121.2 ENSMUST00000157121.3 uc289pkn.1 uc289pkn.2 uc289pkn.1 uc289pkn.2 
ENSMUST00000157122.3 Gm25151 ENSMUST00000157122.3 Gm25151 (from geneSymbol) ENSMUST00000157122.1 ENSMUST00000157122.2 uc287nto.1 uc287nto.2 uc287nto.1 uc287nto.2 
ENSMUST00000157127.3 Gm23467 ENSMUST00000157127.3 Gm23467 (from geneSymbol) ENSMUST00000157127.1 ENSMUST00000157127.2 uc290kbu.1 uc290kbu.2 uc290kbu.1 uc290kbu.2 
ENSMUST00000157129.4 Gm23470 ENSMUST00000157129.4 Gm23470 (from geneSymbol) DQ548138 ENSMUST00000157129.1 ENSMUST00000157129.2 ENSMUST00000157129.3 uc288tim.1 uc288tim.2 uc288tim.1 uc288tim.2 
ENSMUST00000157135.4 Gm23980 ENSMUST00000157135.4 Gm23980 (from geneSymbol) ENSMUST00000157135.1 ENSMUST00000157135.2 ENSMUST00000157135.3 uc288xey.1 uc288xey.2 uc288xey.1 uc288xey.2 
ENSMUST00000157136.4 Gm23981 ENSMUST00000157136.4 Gm23981 (from geneSymbol) ENSMUST00000157136.1 ENSMUST00000157136.2 ENSMUST00000157136.3 uc292bep.1 uc292bep.2 uc292bep.1 uc292bep.2 
ENSMUST00000157139.3 Gm23984 ENSMUST00000157139.3 Gm23984 (from geneSymbol) ENSMUST00000157139.1 ENSMUST00000157139.2 uc287hvm.1 uc287hvm.2 uc287hvm.1 uc287hvm.2 
ENSMUST00000157140.3 Gm23985 ENSMUST00000157140.3 Gm23985 (from geneSymbol) ENSMUST00000157140.1 ENSMUST00000157140.2 uc292qfg.1 uc292qfg.2 uc292qfg.1 uc292qfg.2 
ENSMUST00000157144.3 Gm23986 ENSMUST00000157144.3 Gm23986 (from geneSymbol) ENSMUST00000157144.1 ENSMUST00000157144.2 uc291zwd.1 uc291zwd.2 uc291zwd.1 uc291zwd.2 
ENSMUST00000157147.3 Gm22319 ENSMUST00000157147.3 Gm22319 (from geneSymbol) ENSMUST00000157147.1 ENSMUST00000157147.2 uc288viq.1 uc288viq.2 uc288viq.1 uc288viq.2 
ENSMUST00000157150.3 Rprl2 ENSMUST00000157150.3 ribonuclease P RNA-like 2 (from RefSeq NR_004439.2) ENSMUST00000157150.1 ENSMUST00000157150.2 NR_004439 uc012cny.1 uc012cny.2 uc012cny.3 uc012cny.4 uc012cny.1 uc012cny.2 uc012cny.3 uc012cny.4 
ENSMUST00000157151.3 Gm22322 ENSMUST00000157151.3 Gm22322 (from geneSymbol) ENSMUST00000157151.1 ENSMUST00000157151.2 uc290jui.1 uc290jui.2 uc290jui.1 uc290jui.2 
ENSMUST00000157152.3 Gm22321 ENSMUST00000157152.3 Gm22321 (from geneSymbol) ENSMUST00000157152.1 ENSMUST00000157152.2 uc291djr.1 uc291djr.2 uc291djr.1 uc291djr.2 
ENSMUST00000157155.4 Gm23167 ENSMUST00000157155.4 Gm23167 (from geneSymbol) ENSMUST00000157155.1 ENSMUST00000157155.2 ENSMUST00000157155.3 uc288esr.1 uc288esr.2 uc288esr.1 uc288esr.2 
ENSMUST00000157156.3 Gm23168 ENSMUST00000157156.3 Gm23168 (from geneSymbol) ENSMUST00000157156.1 ENSMUST00000157156.2 uc291vgw.1 uc291vgw.2 uc291vgw.1 uc291vgw.2 
ENSMUST00000157157.3 Gm23169 ENSMUST00000157157.3 Gm23169 (from geneSymbol) ENSMUST00000157157.1 ENSMUST00000157157.2 uc287gol.1 uc287gol.2 uc287gol.1 uc287gol.2 
ENSMUST00000157165.3 Gm25970 ENSMUST00000157165.3 Gm25970 (from geneSymbol) ENSMUST00000157165.1 ENSMUST00000157165.2 uc288gsu.1 uc288gsu.2 uc288gsu.1 uc288gsu.2 
ENSMUST00000157167.3 Gm25968 ENSMUST00000157167.3 Gm25968 (from geneSymbol) ENSMUST00000157167.1 ENSMUST00000157167.2 uc288bew.1 uc288bew.2 uc288bew.1 uc288bew.2 
ENSMUST00000157168.3 Gm25967 ENSMUST00000157168.3 Gm25967 (from geneSymbol) ENSMUST00000157168.1 ENSMUST00000157168.2 LF200725 uc289ejk.1 uc289ejk.2 uc289ejk.1 uc289ejk.2 
ENSMUST00000157170.3 Gm25965 ENSMUST00000157170.3 Gm25965 (from geneSymbol) ENSMUST00000157170.1 ENSMUST00000157170.2 uc290kfl.1 uc290kfl.2 uc290kfl.1 uc290kfl.2 
ENSMUST00000157171.3 Gm25964 ENSMUST00000157171.3 Gm25964 (from geneSymbol) ENSMUST00000157171.1 ENSMUST00000157171.2 uc288qvo.1 uc288qvo.2 uc288qvo.1 uc288qvo.2 
ENSMUST00000157175.3 Gm25569 ENSMUST00000157175.3 Gm25569 (from geneSymbol) ENSMUST00000157175.1 ENSMUST00000157175.2 uc290cnh.1 uc290cnh.2 uc290cnh.1 uc290cnh.2 
ENSMUST00000157177.3 Gm25979 ENSMUST00000157177.3 Gm25979 (from geneSymbol) ENSMUST00000157177.1 ENSMUST00000157177.2 uc287pnt.1 uc287pnt.2 uc287pnt.1 uc287pnt.2 
ENSMUST00000157179.4 Gm23434 ENSMUST00000157179.4 Gm23434 (from geneSymbol) ENSMUST00000157179.1 ENSMUST00000157179.2 ENSMUST00000157179.3 uc287ktz.1 uc287ktz.2 uc287ktz.1 uc287ktz.2 
ENSMUST00000157180.4 Gm27926 ENSMUST00000157180.4 Gm27926 (from geneSymbol) ENSMUST00000157180.1 ENSMUST00000157180.2 ENSMUST00000157180.3 uc288yao.1 uc288yao.2 uc288yao.1 uc288yao.2 
ENSMUST00000157181.3 Gm23432 ENSMUST00000157181.3 Gm23432 (from geneSymbol) ENSMUST00000157181.1 ENSMUST00000157181.2 uc290jcl.1 uc290jcl.2 uc290jcl.1 uc290jcl.2 
ENSMUST00000157183.4 Gm23435 ENSMUST00000157183.4 Gm23435 (from geneSymbol) ENSMUST00000157183.1 ENSMUST00000157183.2 ENSMUST00000157183.3 uc291dng.1 uc291dng.2 uc291dng.1 uc291dng.2 
ENSMUST00000157185.3 Gm25113 ENSMUST00000157185.3 Gm25113 (from geneSymbol) ENSMUST00000157185.1 ENSMUST00000157185.2 uc288bjo.1 uc288bjo.2 uc288bjo.1 uc288bjo.2 
ENSMUST00000157187.3 Gm25115 ENSMUST00000157187.3 Gm25115 (from geneSymbol) ENSMUST00000157187.1 ENSMUST00000157187.2 uc288vyz.1 uc288vyz.2 uc288vyz.1 uc288vyz.2 
ENSMUST00000157188.3 Gm22490 ENSMUST00000157188.3 Gm22490 (from geneSymbol) ENSMUST00000157188.1 ENSMUST00000157188.2 uc290tjs.1 uc290tjs.2 uc290tjs.1 uc290tjs.2 
ENSMUST00000157190.3 Gm22491 ENSMUST00000157190.3 Gm22491 (from geneSymbol) ENSMUST00000157190.1 ENSMUST00000157190.2 uc290fma.1 uc290fma.2 uc290fma.1 uc290fma.2 
ENSMUST00000157191.2 Gm25116 ENSMUST00000157191.2 Gm25116 (from geneSymbol) ENSMUST00000157191.1 uc289nyz.1 uc289nyz.2 uc289nyz.1 uc289nyz.2 
ENSMUST00000157194.3 Gm25117 ENSMUST00000157194.3 Gm25117 (from geneSymbol) ENSMUST00000157194.1 ENSMUST00000157194.2 uc287uvh.1 uc287uvh.2 uc287uvh.1 uc287uvh.2 
ENSMUST00000157195.3 Mir1928 ENSMUST00000157195.3 microRNA 1928 (from RefSeq NR_035449.1) ENSMUST00000157195.1 ENSMUST00000157195.2 NR_035449 uc056yde.1 uc056yde.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yde.1 uc056yde.2 
ENSMUST00000157198.3 Gm22281 ENSMUST00000157198.3 Gm22281 (from geneSymbol) ENSMUST00000157198.1 ENSMUST00000157198.2 LF192689 uc287isz.1 uc287isz.2 uc287isz.1 uc287isz.2 
ENSMUST00000157200.4 Gm22279 ENSMUST00000157200.4 Gm22279 (from geneSymbol) ENSMUST00000157200.1 ENSMUST00000157200.2 ENSMUST00000157200.3 uc290fsd.1 uc290fsd.2 uc290fsd.1 uc290fsd.2 
ENSMUST00000157206.3 Gm23960 ENSMUST00000157206.3 Gm23960 (from geneSymbol) ENSMUST00000157206.1 ENSMUST00000157206.2 uc291cuw.1 uc291cuw.2 uc291cuw.1 uc291cuw.2 
ENSMUST00000157207.4 Gm23958 ENSMUST00000157207.4 Gm23958 (from geneSymbol) ENSMUST00000157207.1 ENSMUST00000157207.2 ENSMUST00000157207.3 uc292qtb.1 uc292qtb.2 uc292qtb.1 uc292qtb.2 
ENSMUST00000157210.4 Gm24481 ENSMUST00000157210.4 Gm24481 (from geneSymbol) ENSMUST00000157210.1 ENSMUST00000157210.2 ENSMUST00000157210.3 uc290hez.1 uc290hez.2 uc290hez.1 uc290hez.2 
ENSMUST00000157214.3 Gm23955 ENSMUST00000157214.3 Gm23955 (from geneSymbol) ENSMUST00000157214.1 ENSMUST00000157214.2 uc288pgy.1 uc288pgy.2 uc288pgy.1 uc288pgy.2 
ENSMUST00000157216.2 Gm25623 ENSMUST00000157216.2 Gm25623 (from geneSymbol) ENSMUST00000157216.1 uc290lrh.1 uc290lrh.2 uc290lrh.1 uc290lrh.2 
ENSMUST00000157217.3 Gm25622 ENSMUST00000157217.3 Gm25622 (from geneSymbol) ENSMUST00000157217.1 ENSMUST00000157217.2 uc288jrc.1 uc288jrc.2 uc288jrc.1 uc288jrc.2 
ENSMUST00000157219.2 Mir1958 ENSMUST00000157219.2 microRNA 1958 (from RefSeq NR_035484.1) ENSMUST00000157219.1 NR_035484 uc056zwb.1 uc056zwb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zwb.1 uc056zwb.2 
ENSMUST00000157222.3 Gm25624 ENSMUST00000157222.3 Gm25624 (from geneSymbol) ENSMUST00000157222.1 ENSMUST00000157222.2 uc292nrk.1 uc292nrk.2 uc292nrk.1 uc292nrk.2 
ENSMUST00000157225.3 Gm22792 ENSMUST00000157225.3 Gm22792 (from geneSymbol) ENSMUST00000157225.1 ENSMUST00000157225.2 uc291kdg.1 uc291kdg.2 uc291kdg.1 uc291kdg.2 
ENSMUST00000157230.3 Mir432 ENSMUST00000157230.3 microRNA 432 (from RefSeq NR_035526.1) ENSMUST00000157230.1 ENSMUST00000157230.2 NR_035526 uc011ysn.1 uc011ysn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011ysn.1 uc011ysn.2 
ENSMUST00000157232.3 Gm22791 ENSMUST00000157232.3 Gm22791 (from geneSymbol) ENSMUST00000157232.1 ENSMUST00000157232.2 uc289pbj.1 uc289pbj.2 uc289pbj.1 uc289pbj.2 
ENSMUST00000157233.3 Gm22795 ENSMUST00000157233.3 Gm22795 (from geneSymbol) ENSMUST00000157233.1 ENSMUST00000157233.2 uc290dwd.1 uc290dwd.2 uc290dwd.1 uc290dwd.2 
ENSMUST00000157236.3 Gm24440 ENSMUST00000157236.3 Gm24440 (from geneSymbol) ENSMUST00000157236.1 ENSMUST00000157236.2 uc289dvm.1 uc289dvm.2 uc289dvm.1 uc289dvm.2 
ENSMUST00000157237.3 Gm23048 ENSMUST00000157237.3 Gm23048 (from geneSymbol) ENSMUST00000157237.1 ENSMUST00000157237.2 uc292etv.1 uc292etv.2 uc292etv.1 uc292etv.2 
ENSMUST00000157242.3 Gm24443 ENSMUST00000157242.3 Gm24443 (from geneSymbol) ENSMUST00000157242.1 ENSMUST00000157242.2 uc291cxw.1 uc291cxw.2 uc291cxw.1 uc291cxw.2 
ENSMUST00000157245.3 Gm26100 ENSMUST00000157245.3 Gm26100 (from geneSymbol) ENSMUST00000157245.1 ENSMUST00000157245.2 uc292eel.1 uc292eel.2 uc292eel.1 uc292eel.2 
ENSMUST00000157246.3 Gm26101 ENSMUST00000157246.3 Gm26101 (from geneSymbol) ENSMUST00000157246.1 ENSMUST00000157246.2 uc292jqf.1 uc292jqf.2 uc292jqf.1 uc292jqf.2 
ENSMUST00000157248.3 Gm26099 ENSMUST00000157248.3 Gm26099 (from geneSymbol) ENSMUST00000157248.1 ENSMUST00000157248.2 uc292nsz.1 uc292nsz.2 uc292nsz.1 uc292nsz.2 
ENSMUST00000157250.4 Gm26104 ENSMUST00000157250.4 Gm26104 (from geneSymbol) DQ558729 ENSMUST00000157250.1 ENSMUST00000157250.2 ENSMUST00000157250.3 uc287oeo.1 uc287oeo.2 uc287oeo.1 uc287oeo.2 
ENSMUST00000157253.3 Gm26105 ENSMUST00000157253.3 Gm26105 (from geneSymbol) ENSMUST00000157253.1 ENSMUST00000157253.2 uc291jtl.1 uc291jtl.2 uc291jtl.1 uc291jtl.2 
ENSMUST00000157255.3 Gm23605 ENSMUST00000157255.3 Gm23605 (from geneSymbol) ENSMUST00000157255.1 ENSMUST00000157255.2 uc290wdg.1 uc290wdg.2 uc290wdg.1 uc290wdg.2 
ENSMUST00000157256.3 Gm22442 ENSMUST00000157256.3 Gm22442 (from geneSymbol) ENSMUST00000157256.1 ENSMUST00000157256.2 uc287zgs.1 uc287zgs.2 uc287zgs.1 uc287zgs.2 
ENSMUST00000157258.3 Gm23602 ENSMUST00000157258.3 Gm23602 (from geneSymbol) ENSMUST00000157258.1 ENSMUST00000157258.2 uc287kuf.1 uc287kuf.2 uc287kuf.1 uc287kuf.2 
ENSMUST00000157259.3 Gm23601 ENSMUST00000157259.3 Gm23601 (from geneSymbol) ENSMUST00000157259.1 ENSMUST00000157259.2 uc287pnc.1 uc287pnc.2 uc287pnc.1 uc287pnc.2 
ENSMUST00000157262.3 Gm23598 ENSMUST00000157262.3 Gm23598 (from geneSymbol) ENSMUST00000157262.1 ENSMUST00000157262.2 uc290bgn.1 uc290bgn.2 uc290bgn.1 uc290bgn.2 
ENSMUST00000157263.4 Gm27393 ENSMUST00000157263.4 Gm27393 (from geneSymbol) ENSMUST00000157263.1 ENSMUST00000157263.2 ENSMUST00000157263.3 uc287wpa.1 uc287wpa.2 uc287wpa.1 uc287wpa.2 
ENSMUST00000157267.3 Gm25278 ENSMUST00000157267.3 Gm25278 (from geneSymbol) ENSMUST00000157267.1 ENSMUST00000157267.2 uc291yng.1 uc291yng.2 uc291yng.1 uc291yng.2 
ENSMUST00000157268.3 Gm23441 ENSMUST00000157268.3 Gm23441 (from geneSymbol) ENSMUST00000157268.1 ENSMUST00000157268.2 uc290dzc.1 uc290dzc.2 uc290dzc.1 uc290dzc.2 
ENSMUST00000157269.3 Gm25280 ENSMUST00000157269.3 Gm25280 (from geneSymbol) ENSMUST00000157269.1 ENSMUST00000157269.2 uc290rdl.1 uc290rdl.2 uc290rdl.1 uc290rdl.2 
ENSMUST00000157272.3 Gm25283 ENSMUST00000157272.3 Gm25283 (from geneSymbol) ENSMUST00000157272.1 ENSMUST00000157272.2 uc291edf.1 uc291edf.2 uc291edf.1 uc291edf.2 
ENSMUST00000157274.3 Mir1942 ENSMUST00000157274.3 microRNA 1942 (from RefSeq NR_035463.1) ENSMUST00000157274.1 ENSMUST00000157274.2 NR_035463 uc011zur.1 uc011zur.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011zur.1 uc011zur.2 
ENSMUST00000157278.3 Gm22039 ENSMUST00000157278.3 Gm22039 (from geneSymbol) ENSMUST00000157278.1 ENSMUST00000157278.2 LF204830 uc290rls.1 uc290rls.2 uc290rls.1 uc290rls.2 
ENSMUST00000157283.3 Gm22034 ENSMUST00000157283.3 Gm22034 (from geneSymbol) ENSMUST00000157283.1 ENSMUST00000157283.2 uc287kuw.1 uc287kuw.2 uc287kuw.1 uc287kuw.2 
ENSMUST00000157287.3 Gm24916 ENSMUST00000157287.3 Gm24916 (from geneSymbol) ENSMUST00000157287.1 ENSMUST00000157287.2 uc288rzn.1 uc288rzn.2 uc288rzn.1 uc288rzn.2 
ENSMUST00000157291.3 Gm24912 ENSMUST00000157291.3 Gm24912 (from geneSymbol) ENSMUST00000157291.1 ENSMUST00000157291.2 uc288rep.1 uc288rep.2 uc288rep.1 uc288rep.2 
ENSMUST00000157292.3 Gm24911 ENSMUST00000157292.3 Gm24911 (from geneSymbol) ENSMUST00000157292.1 ENSMUST00000157292.2 uc291fgi.1 uc291fgi.2 uc291fgi.1 uc291fgi.2 
ENSMUST00000157294.2 Gm24908 ENSMUST00000157294.2 Gm24908 (from geneSymbol) ENSMUST00000157294.1 uc290lgv.1 uc290lgv.2 uc290lgv.1 uc290lgv.2 
ENSMUST00000157297.3 Gm23229 ENSMUST00000157297.3 Gm23229 (from geneSymbol) ENSMUST00000157297.1 ENSMUST00000157297.2 uc291uuy.1 uc291uuy.2 uc291uuy.1 uc291uuy.2 
ENSMUST00000157298.3 Gm23230 ENSMUST00000157298.3 Gm23230 (from geneSymbol) ENSMUST00000157298.1 ENSMUST00000157298.2 uc290oue.1 uc290oue.2 uc290oue.1 uc290oue.2 
ENSMUST00000157299.3 Gm23231 ENSMUST00000157299.3 Gm23231 (from geneSymbol) ENSMUST00000157299.1 ENSMUST00000157299.2 uc291doy.1 uc291doy.2 uc291doy.1 uc291doy.2 
ENSMUST00000157301.3 Gm23233 ENSMUST00000157301.3 Gm23233 (from geneSymbol) ENSMUST00000157301.1 ENSMUST00000157301.2 uc291rec.1 uc291rec.2 uc291rec.1 uc291rec.2 
ENSMUST00000157304.3 Gm23234 ENSMUST00000157304.3 Gm23234 (from geneSymbol) ENSMUST00000157304.1 ENSMUST00000157304.2 uc291hll.1 uc291hll.2 uc291hll.1 uc291hll.2 
ENSMUST00000157305.3 Gm26048 ENSMUST00000157305.3 Gm26048 (from geneSymbol) ENSMUST00000157305.1 ENSMUST00000157305.2 uc287mgt.1 uc287mgt.2 uc287mgt.1 uc287mgt.2 
ENSMUST00000157307.3 Mir1971 ENSMUST00000157307.3 microRNA 1971 (from RefSeq NR_035499.1) ENSMUST00000157307.1 ENSMUST00000157307.2 NR_035499 uc011zou.1 uc011zou.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011zou.1 uc011zou.2 
ENSMUST00000157308.3 Gm26047 ENSMUST00000157308.3 Gm26047 (from geneSymbol) ENSMUST00000157308.1 ENSMUST00000157308.2 uc290ofu.1 uc290ofu.2 uc290ofu.1 uc290ofu.2 
ENSMUST00000157310.3 Snora81 ENSMUST00000157310.3 small nucleolar RNA, H/ACA box 81 (from RefSeq NR_034048.1) ENSMUST00000157310.1 ENSMUST00000157310.2 NR_034048 uc289dtn.1 uc289dtn.2 uc289dtn.1 uc289dtn.2 
ENSMUST00000157311.3 Gm23675 ENSMUST00000157311.3 Gm23675 (from geneSymbol) ENSMUST00000157311.1 ENSMUST00000157311.2 uc290ffu.1 uc290ffu.2 uc290ffu.1 uc290ffu.2 
ENSMUST00000157312.3 Gm26046 ENSMUST00000157312.3 Gm26046 (from geneSymbol) ENSMUST00000157312.1 ENSMUST00000157312.2 uc289rqe.1 uc289rqe.2 uc289rqe.1 uc289rqe.2 
ENSMUST00000157313.4 Gm26049 ENSMUST00000157313.4 Gm26049 (from geneSymbol) ENSMUST00000157313.1 ENSMUST00000157313.2 ENSMUST00000157313.3 uc290lxd.1 uc290lxd.2 uc290lxd.1 uc290lxd.2 
ENSMUST00000157314.3 Gm23676 ENSMUST00000157314.3 Gm23676 (from geneSymbol) ENSMUST00000157314.1 ENSMUST00000157314.2 uc288eru.1 uc288eru.2 uc288eru.1 uc288eru.2 
ENSMUST00000157315.3 Gm24246 ENSMUST00000157315.3 Gm24246 (from geneSymbol) ENSMUST00000157315.1 ENSMUST00000157315.2 uc289olg.1 uc289olg.2 uc289olg.1 uc289olg.2 
ENSMUST00000157317.3 Gm24244 ENSMUST00000157317.3 Gm24244 (from geneSymbol) ENSMUST00000157317.1 ENSMUST00000157317.2 uc289nmu.1 uc289nmu.2 uc289nmu.1 uc289nmu.2 
ENSMUST00000157322.3 Gm24249 ENSMUST00000157322.3 Gm24249 (from geneSymbol) ENSMUST00000157322.1 ENSMUST00000157322.2 uc291sku.1 uc291sku.2 uc291sku.1 uc291sku.2 
ENSMUST00000157324.3 Gm24251 ENSMUST00000157324.3 Gm24251 (from geneSymbol) ENSMUST00000157324.1 ENSMUST00000157324.2 uc287idf.1 uc287idf.2 uc287idf.1 uc287idf.2 
ENSMUST00000157325.3 Mir1948 ENSMUST00000157325.3 microRNA 1948 (from RefSeq NR_035471.1) ENSMUST00000157325.1 ENSMUST00000157325.2 NR_035471 uc012azl.1 uc012azl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610472.1 [ECO:0000345] ##Evidence-Data-END## uc012azl.1 uc012azl.2 
ENSMUST00000157329.3 Gm22559 ENSMUST00000157329.3 Gm22559 (from geneSymbol) ENSMUST00000157329.1 ENSMUST00000157329.2 uc290vta.1 uc290vta.2 uc290vta.1 uc290vta.2 
ENSMUST00000157338.3 Gm25394 ENSMUST00000157338.3 Gm25394 (from geneSymbol) ENSMUST00000157338.1 ENSMUST00000157338.2 uc288msc.1 uc288msc.2 uc288msc.1 uc288msc.2 
ENSMUST00000157339.4 Gm25388 ENSMUST00000157339.4 Gm25388 (from geneSymbol) ENSMUST00000157339.1 ENSMUST00000157339.2 ENSMUST00000157339.3 uc289wfd.1 uc289wfd.2 uc289wfd.1 uc289wfd.2 
ENSMUST00000157341.4 Gm25390 ENSMUST00000157341.4 Gm25390 (from geneSymbol) ENSMUST00000157341.1 ENSMUST00000157341.2 ENSMUST00000157341.3 uc287uba.1 uc287uba.2 uc287uba.1 uc287uba.2 
ENSMUST00000157342.3 Gm25391 ENSMUST00000157342.3 Gm25391 (from geneSymbol) ENSMUST00000157342.1 ENSMUST00000157342.2 uc290ndu.1 uc290ndu.2 uc290ndu.1 uc290ndu.2 
ENSMUST00000157343.3 Gm25395 ENSMUST00000157343.3 Gm25395 (from geneSymbol) ENSMUST00000157343.1 ENSMUST00000157343.2 uc287keb.1 uc287keb.2 uc287keb.1 uc287keb.2 
ENSMUST00000157348.3 Gm23716 ENSMUST00000157348.3 Gm23716 (from geneSymbol) ENSMUST00000157348.1 ENSMUST00000157348.2 uc289xon.1 uc289xon.2 uc289xon.1 uc289xon.2 
ENSMUST00000157355.3 Gm22226 ENSMUST00000157355.3 Gm22226 (from geneSymbol) ENSMUST00000157355.1 ENSMUST00000157355.2 uc291stp.1 uc291stp.2 uc291stp.1 uc291stp.2 
ENSMUST00000157360.3 Gm22223 ENSMUST00000157360.3 Gm22223 (from geneSymbol) ENSMUST00000157360.1 ENSMUST00000157360.2 uc292coc.1 uc292coc.2 uc292coc.1 uc292coc.2 
ENSMUST00000157362.3 Gm22221 ENSMUST00000157362.3 Gm22221 (from geneSymbol) ENSMUST00000157362.1 ENSMUST00000157362.2 uc290pyu.1 uc290pyu.2 uc290pyu.1 uc290pyu.2 
ENSMUST00000157363.4 Gm22476 ENSMUST00000157363.4 Gm22476 (from geneSymbol) ENSMUST00000157363.1 ENSMUST00000157363.2 ENSMUST00000157363.3 uc288kuo.1 uc288kuo.2 uc288kuo.1 uc288kuo.2 
ENSMUST00000157365.4 Gm25058 ENSMUST00000157365.4 Gm25058 (from geneSymbol) ENSMUST00000157365.1 ENSMUST00000157365.2 ENSMUST00000157365.3 uc287wrc.1 uc287wrc.2 uc287wrc.1 uc287wrc.2 
ENSMUST00000157367.3 Gm25059 ENSMUST00000157367.3 Gm25059 (from geneSymbol) ENSMUST00000157367.1 ENSMUST00000157367.2 uc292lxa.1 uc292lxa.2 uc292lxa.1 uc292lxa.2 
ENSMUST00000157368.3 Mir1982 ENSMUST00000157368.3 microRNA 1982 (from RefSeq NR_035503.1) ENSMUST00000157368.1 ENSMUST00000157368.2 NR_035503 uc011xiz.1 uc011xiz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610505.1 [ECO:0000345] ##Evidence-Data-END## uc011xiz.1 uc011xiz.2 
ENSMUST00000157370.3 Gm25054 ENSMUST00000157370.3 Gm25054 (from geneSymbol) ENSMUST00000157370.1 ENSMUST00000157370.2 uc291ggq.1 uc291ggq.2 uc291ggq.1 uc291ggq.2 
ENSMUST00000157372.3 Gm25056 ENSMUST00000157372.3 Gm25056 (from geneSymbol) ENSMUST00000157372.1 ENSMUST00000157372.2 uc290knv.1 uc290knv.2 uc290knv.1 uc290knv.2 
ENSMUST00000157376.3 Gm22883 ENSMUST00000157376.3 Gm22883 (from geneSymbol) ENSMUST00000157376.1 ENSMUST00000157376.2 uc288bdn.1 uc288bdn.2 uc288bdn.1 uc288bdn.2 
ENSMUST00000157377.3 Gm24775 ENSMUST00000157377.3 Gm24775 (from geneSymbol) ENSMUST00000157377.1 ENSMUST00000157377.2 uc288hiy.1 uc288hiy.2 uc288hiy.1 uc288hiy.2 
ENSMUST00000157380.3 Gm24787 ENSMUST00000157380.3 Gm24787 (from geneSymbol) ENSMUST00000157380.1 ENSMUST00000157380.2 uc288yph.1 uc288yph.2 uc288yph.1 uc288yph.2 
ENSMUST00000157383.3 Gm25492 ENSMUST00000157383.3 Gm25492 (from geneSymbol) ENSMUST00000157383.1 ENSMUST00000157383.2 uc291amz.1 uc291amz.2 uc291amz.1 uc291amz.2 
ENSMUST00000157384.3 Gm24774 ENSMUST00000157384.3 Gm24774 (from geneSymbol) ENSMUST00000157384.1 ENSMUST00000157384.2 uc288vyb.1 uc288vyb.2 uc288vyb.1 uc288vyb.2 
ENSMUST00000157390.3 Mir1932 ENSMUST00000157390.3 microRNA 1932 (from RefSeq NR_035453.1) ENSMUST00000157390.1 ENSMUST00000157390.2 NR_035453 uc011yis.1 uc011yis.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610462.1 [ECO:0000345] ##Evidence-Data-END## uc011yis.1 uc011yis.2 
ENSMUST00000157393.4 Gm23390 ENSMUST00000157393.4 Gm23390 (from geneSymbol) ENSMUST00000157393.1 ENSMUST00000157393.2 ENSMUST00000157393.3 uc289yjq.1 uc289yjq.2 uc289yjq.1 uc289yjq.2 
ENSMUST00000157394.3 Gm23826 ENSMUST00000157394.3 Gm23826 (from geneSymbol) ENSMUST00000157394.1 ENSMUST00000157394.2 uc288guq.1 uc288guq.2 uc288guq.1 uc288guq.2 
ENSMUST00000157395.3 Gm22762 ENSMUST00000157395.3 Gm22762 (from geneSymbol) ENSMUST00000157395.1 ENSMUST00000157395.2 uc288bjh.1 uc288bjh.2 uc288bjh.1 uc288bjh.2 
ENSMUST00000157396.3 Gm22145 ENSMUST00000157396.3 Gm22145 (from geneSymbol) ENSMUST00000157396.1 ENSMUST00000157396.2 uc292ijh.1 uc292ijh.2 uc292ijh.1 uc292ijh.2 
ENSMUST00000157398.5 Gm55150 ENSMUST00000157398.5 Gm55150 (from geneSymbol) ENSMUST00000157398.1 ENSMUST00000157398.2 ENSMUST00000157398.3 ENSMUST00000157398.4 uc287qyq.1 uc287qyq.2 uc287qyq.1 uc287qyq.2 
ENSMUST00000157400.3 Rprl3 ENSMUST00000157400.3 ribonuclease P RNA-like 3 (from RefSeq NR_024198.3) ENSMUST00000157400.1 ENSMUST00000157400.2 NR_024198 uc291xvi.1 uc291xvi.2 uc291xvi.1 uc291xvi.2 
ENSMUST00000157402.3 Gm22144 ENSMUST00000157402.3 Gm22144 (from geneSymbol) ENSMUST00000157402.1 ENSMUST00000157402.2 uc289rkw.1 uc289rkw.2 uc289rkw.1 uc289rkw.2 
ENSMUST00000157412.3 Gm24992 ENSMUST00000157412.3 Gm24992 (from geneSymbol) ENSMUST00000157412.1 ENSMUST00000157412.2 uc291yxh.1 uc291yxh.2 uc291yxh.1 uc291yxh.2 
ENSMUST00000157414.3 Gm24994 ENSMUST00000157414.3 Gm24994 (from geneSymbol) ENSMUST00000157414.1 ENSMUST00000157414.2 uc288hji.1 uc288hji.2 uc288hji.1 uc288hji.2 
ENSMUST00000157415.4 Gm23329 ENSMUST00000157415.4 Gm23329 (from geneSymbol) ENSMUST00000157415.1 ENSMUST00000157415.2 ENSMUST00000157415.3 uc292acr.1 uc292acr.2 uc292acr.1 uc292acr.2 
ENSMUST00000157416.3 Gm25261 ENSMUST00000157416.3 Gm25261 (from geneSymbol) ENSMUST00000157416.1 ENSMUST00000157416.2 uc290qia.1 uc290qia.2 uc290qia.1 uc290qia.2 
ENSMUST00000157418.3 Gm23328 ENSMUST00000157418.3 Gm23328 (from geneSymbol) ENSMUST00000157418.1 ENSMUST00000157418.2 uc289wom.1 uc289wom.2 uc289wom.1 uc289wom.2 
ENSMUST00000157419.3 Gm23326 ENSMUST00000157419.3 Gm23326 (from geneSymbol) ENSMUST00000157419.1 ENSMUST00000157419.2 uc292gks.1 uc292gks.2 uc292gks.1 uc292gks.2 
ENSMUST00000157420.4 Gm23327 ENSMUST00000157420.4 Gm23327 (from geneSymbol) ENSMUST00000157420.1 ENSMUST00000157420.2 ENSMUST00000157420.3 uc288xit.1 uc288xit.2 uc288xit.1 uc288xit.2 
ENSMUST00000157421.3 Gm23324 ENSMUST00000157421.3 Gm23324 (from geneSymbol) ENSMUST00000157421.1 ENSMUST00000157421.2 uc288wbq.1 uc288wbq.2 uc288wbq.1 uc288wbq.2 
ENSMUST00000157422.3 Gm23325 ENSMUST00000157422.3 Gm23325 (from geneSymbol) ENSMUST00000157422.1 ENSMUST00000157422.2 uc292qxb.1 uc292qxb.2 uc292qxb.1 uc292qxb.2 
ENSMUST00000157423.3 Gm23331 ENSMUST00000157423.3 Gm23331 (from geneSymbol) ENSMUST00000157423.1 ENSMUST00000157423.2 uc290vrm.1 uc290vrm.2 uc290vrm.1 uc290vrm.2 
ENSMUST00000157425.4 Gm54363 ENSMUST00000157425.4 Gm54363 (from geneSymbol) ENSMUST00000157425.1 ENSMUST00000157425.2 ENSMUST00000157425.3 uc292qzf.1 uc292qzf.2 uc292qzf.1 uc292qzf.2 
ENSMUST00000157426.3 Gm26150 ENSMUST00000157426.3 Gm26150 (from geneSymbol) ENSMUST00000157426.1 ENSMUST00000157426.2 uc291zje.1 uc291zje.2 uc291zje.1 uc291zje.2 
ENSMUST00000157429.3 Mir1968 ENSMUST00000157429.3 microRNA 1968 (from RefSeq NR_035494.1) ENSMUST00000157429.1 ENSMUST00000157429.2 NR_035494 uc012fzw.1 uc012fzw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610493.1 [ECO:0000345] ##Evidence-Data-END## uc012fzw.1 uc012fzw.2 
ENSMUST00000157430.4 Gm26148 ENSMUST00000157430.4 Gm26148 (from geneSymbol) ENSMUST00000157430.1 ENSMUST00000157430.2 ENSMUST00000157430.3 uc290lht.1 uc290lht.2 uc290lht.1 uc290lht.2 
ENSMUST00000157433.3 Gm26153 ENSMUST00000157433.3 Gm26153 (from geneSymbol) ENSMUST00000157433.1 ENSMUST00000157433.2 uc289fsg.1 uc289fsg.2 uc289fsg.1 uc289fsg.2 
ENSMUST00000157435.3 Gm24475 ENSMUST00000157435.3 Gm24475 (from geneSymbol) ENSMUST00000157435.1 ENSMUST00000157435.2 uc289muh.1 uc289muh.2 uc289muh.1 uc289muh.2 
ENSMUST00000157443.3 Gm47290 ENSMUST00000157443.3 Gm47290 (from geneSymbol) ENSMUST00000157443.1 ENSMUST00000157443.2 uc288haa.1 uc288haa.2 uc288haa.1 uc288haa.2 
ENSMUST00000157446.3 Gm22818 ENSMUST00000157446.3 Gm22818 (from geneSymbol) ENSMUST00000157446.1 ENSMUST00000157446.2 uc289alv.1 uc289alv.2 uc289alv.1 uc289alv.2 
ENSMUST00000157448.2 Gm22817 ENSMUST00000157448.2 Gm22817 (from geneSymbol) ENSMUST00000157448.1 uc290ljw.1 uc290ljw.2 uc290ljw.1 uc290ljw.2 
ENSMUST00000157451.3 Gm22815 ENSMUST00000157451.3 Gm22815 (from geneSymbol) ENSMUST00000157451.1 ENSMUST00000157451.2 uc292ejy.1 uc292ejy.2 uc292ejy.1 uc292ejy.2 
ENSMUST00000157459.3 Gm25342 ENSMUST00000157459.3 Gm25342 (from geneSymbol) ENSMUST00000157459.1 ENSMUST00000157459.2 uc287urs.1 uc287urs.2 uc287urs.1 uc287urs.2 
ENSMUST00000157463.2 Rmrp ENSMUST00000157463.2 RNA component of mitochondrial RNAase P (from RefSeq NR_001460.1) ENSMUST00000157463.1 NR_001460 uc290mev.1 uc290mev.2 uc290mev.1 uc290mev.2 
ENSMUST00000157467.3 Gm22722 ENSMUST00000157467.3 Gm22722 (from geneSymbol) ENSMUST00000157467.1 ENSMUST00000157467.2 uc291irf.1 uc291irf.2 uc291irf.1 uc291irf.2 
ENSMUST00000157468.3 Gm22811 ENSMUST00000157468.3 Gm22811 (from geneSymbol) ENSMUST00000157468.1 ENSMUST00000157468.2 uc287qgo.1 uc287qgo.2 uc287qgo.1 uc287qgo.2 
ENSMUST00000157469.3 Gm23670 ENSMUST00000157469.3 Gm23670 (from geneSymbol) ENSMUST00000157469.1 ENSMUST00000157469.2 uc290dud.1 uc290dud.2 uc290dud.1 uc290dud.2 
ENSMUST00000157470.3 Gm23669 ENSMUST00000157470.3 Gm23669 (from geneSymbol) ENSMUST00000157470.1 ENSMUST00000157470.2 uc288wls.1 uc288wls.2 uc288wls.1 uc288wls.2 
ENSMUST00000157473.3 Gm23674 ENSMUST00000157473.3 Gm23674 (from geneSymbol) ENSMUST00000157473.1 ENSMUST00000157473.2 uc289okv.1 uc289okv.2 uc289okv.1 uc289okv.2 
ENSMUST00000157478.3 Gm23993 ENSMUST00000157478.3 Gm23993 (from geneSymbol) ENSMUST00000157478.1 ENSMUST00000157478.2 uc290szh.1 uc290szh.2 uc290szh.1 uc290szh.2 
ENSMUST00000157479.3 Gm22380 ENSMUST00000157479.3 Gm22380 (from geneSymbol) ENSMUST00000157479.1 ENSMUST00000157479.2 uc292fgr.1 uc292fgr.2 uc292fgr.1 uc292fgr.2 
ENSMUST00000157480.3 Gm22379 ENSMUST00000157480.3 Gm22379 (from geneSymbol) ENSMUST00000157480.1 ENSMUST00000157480.2 uc288wmd.1 uc288wmd.2 uc288wmd.1 uc288wmd.2 
ENSMUST00000157481.3 Gm22378 ENSMUST00000157481.3 Gm22378 (from geneSymbol) ENSMUST00000157481.1 ENSMUST00000157481.2 uc288dez.1 uc288dez.2 uc288dez.1 uc288dez.2 
ENSMUST00000157483.3 Snora47 ENSMUST00000157483.3 small nucleolar RNA, H/ACA box 47 (from RefSeq NR_034043.1) ENSMUST00000157483.1 ENSMUST00000157483.2 NR_034043 uc011zcy.1 uc011zcy.2 uc011zcy.3 uc011zcy.4 uc011zcy.1 uc011zcy.2 uc011zcy.3 uc011zcy.4 
ENSMUST00000157486.3 Gm24064 ENSMUST00000157486.3 Gm24064 (from geneSymbol) ENSMUST00000157486.1 ENSMUST00000157486.2 uc287gyr.1 uc287gyr.2 uc287gyr.1 uc287gyr.2 
ENSMUST00000157488.3 Mir1960 ENSMUST00000157488.3 microRNA 1960 (from RefSeq NR_035486.1) ENSMUST00000157488.1 ENSMUST00000157488.2 NR_035486 uc012duc.1 uc012duc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610487.1 [ECO:0000345] ##Evidence-Data-END## uc012duc.1 uc012duc.2 
ENSMUST00000157489.3 Gm24061 ENSMUST00000157489.3 Gm24061 (from geneSymbol) ENSMUST00000157489.1 ENSMUST00000157489.2 uc292prb.1 uc292prb.2 uc292prb.1 uc292prb.2 
ENSMUST00000157496.3 Gm25721 ENSMUST00000157496.3 Gm25721 (from geneSymbol) ENSMUST00000157496.1 ENSMUST00000157496.2 uc290xqf.1 uc290xqf.2 uc290xqf.1 uc290xqf.2 
ENSMUST00000157500.3 Gm26070 ENSMUST00000157500.3 Gm26070 (from geneSymbol) ENSMUST00000157500.1 ENSMUST00000157500.2 uc287xjx.1 uc287xjx.2 uc287xjx.1 uc287xjx.2 
ENSMUST00000157501.3 Gm22870 ENSMUST00000157501.3 Gm22870 (from geneSymbol) ENSMUST00000157501.1 ENSMUST00000157501.2 uc289olw.1 uc289olw.2 uc289olw.1 uc289olw.2 
ENSMUST00000157509.3 Gm22310 ENSMUST00000157509.3 Gm22310 (from geneSymbol) ENSMUST00000157509.1 ENSMUST00000157509.2 uc290axx.1 uc290axx.2 uc290axx.1 uc290axx.2 
ENSMUST00000157510.3 Gm22588 ENSMUST00000157510.3 Gm22588 (from geneSymbol) ENSMUST00000157510.1 ENSMUST00000157510.2 uc287xes.1 uc287xes.2 uc287xes.1 uc287xes.2 
ENSMUST00000157514.4 Gm27343 ENSMUST00000157514.4 Gm27343 (from geneSymbol) ENSMUST00000157514.1 ENSMUST00000157514.2 ENSMUST00000157514.3 uc290bkb.1 uc290bkb.2 uc290bkb.1 uc290bkb.2 
ENSMUST00000157516.3 Mir1962 ENSMUST00000157516.3 microRNA 1962 (from RefSeq NR_035488.1) ENSMUST00000157516.1 ENSMUST00000157516.2 NR_035488 uc012fvl.1 uc012fvl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610488.1 [ECO:0000345] ##Evidence-Data-END## uc012fvl.1 uc012fvl.2 
ENSMUST00000157520.3 Gm24719 ENSMUST00000157520.3 Gm24719 (from geneSymbol) ENSMUST00000157520.1 ENSMUST00000157520.2 uc287mzg.1 uc287mzg.2 uc287mzg.1 uc287mzg.2 
ENSMUST00000157521.3 Gm24718 ENSMUST00000157521.3 Gm24718 (from geneSymbol) ENSMUST00000157521.1 ENSMUST00000157521.2 LF202130 uc292pnq.1 uc292pnq.2 uc292pnq.1 uc292pnq.2 
ENSMUST00000157522.3 Gm24717 ENSMUST00000157522.3 Gm24717 (from geneSymbol) ENSMUST00000157522.1 ENSMUST00000157522.2 uc287vyu.1 uc287vyu.2 uc287vyu.1 uc287vyu.2 
ENSMUST00000157523.3 Mir1983 ENSMUST00000157523.3 microRNA 1983 (from RefSeq NR_035500.1) ENSMUST00000157523.1 ENSMUST00000157523.2 NR_035500 uc011ywv.1 uc011ywv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011ywv.1 uc011ywv.2 
ENSMUST00000157524.3 Gm24716 ENSMUST00000157524.3 Gm24716 (from geneSymbol) ENSMUST00000157524.1 ENSMUST00000157524.2 uc288neb.1 uc288neb.2 uc288neb.1 uc288neb.2 
ENSMUST00000157526.3 Gm26347 ENSMUST00000157526.3 Gm26347 (from geneSymbol) ENSMUST00000157526.1 ENSMUST00000157526.2 uc287vtj.1 uc287vtj.2 uc287vtj.1 uc287vtj.2 
ENSMUST00000157527.4 Gm25572 ENSMUST00000157527.4 Gm25572 (from geneSymbol) ENSMUST00000157527.1 ENSMUST00000157527.2 ENSMUST00000157527.3 uc290fmb.1 uc290fmb.2 uc290fmb.1 uc290fmb.2 
ENSMUST00000157529.2 Gm25637 ENSMUST00000157529.2 Gm25637 (from geneSymbol) ENSMUST00000157529.1 uc290lwh.1 uc290lwh.2 uc290lwh.1 uc290lwh.2 
ENSMUST00000157530.3 Gm26349 ENSMUST00000157530.3 Gm26349 (from geneSymbol) ENSMUST00000157530.1 ENSMUST00000157530.2 uc288qea.1 uc288qea.2 uc288qea.1 uc288qea.2 
ENSMUST00000157532.4 Gm26351 ENSMUST00000157532.4 Gm26351 (from geneSymbol) ENSMUST00000157532.1 ENSMUST00000157532.2 ENSMUST00000157532.3 uc292oif.1 uc292oif.2 uc292oif.1 uc292oif.2 
ENSMUST00000157534.3 Gm26345 ENSMUST00000157534.3 Gm26345 (from geneSymbol) ENSMUST00000157534.1 ENSMUST00000157534.2 uc287gpm.1 uc287gpm.2 uc287gpm.1 uc287gpm.2 
ENSMUST00000157535.4 Gm23538 ENSMUST00000157535.4 Gm23538 (from geneSymbol) ENSMUST00000157535.1 ENSMUST00000157535.2 ENSMUST00000157535.3 uc288wew.1 uc288wew.2 uc288wew.1 uc288wew.2 
ENSMUST00000157539.4 Gm23534 ENSMUST00000157539.4 Gm23534 (from geneSymbol) ENSMUST00000157539.1 ENSMUST00000157539.2 ENSMUST00000157539.3 uc287mdo.1 uc287mdo.2 uc287mdo.1 uc287mdo.2 
ENSMUST00000157542.4 Gm23535 ENSMUST00000157542.4 Gm23535 (from geneSymbol) ENSMUST00000157542.1 ENSMUST00000157542.2 ENSMUST00000157542.3 uc287mkp.1 uc287mkp.2 uc287mkp.1 uc287mkp.2 
ENSMUST00000157543.3 Gm23540 ENSMUST00000157543.3 Gm23540 (from geneSymbol) ENSMUST00000157543.1 ENSMUST00000157543.2 LF194594 uc290pnw.1 uc290pnw.2 uc290pnw.1 uc290pnw.2 
ENSMUST00000157544.3 Gm22059 ENSMUST00000157544.3 Gm22059 (from geneSymbol) ENSMUST00000157544.1 ENSMUST00000157544.2 LF198855 uc288bzn.1 uc288bzn.2 uc288bzn.1 uc288bzn.2 
ENSMUST00000157547.3 Gm25217 ENSMUST00000157547.3 Gm25217 (from geneSymbol) ENSMUST00000157547.1 ENSMUST00000157547.2 uc291uzg.1 uc291uzg.2 uc291uzg.1 uc291uzg.2 
ENSMUST00000157550.3 Gm23101 ENSMUST00000157550.3 Gm23101 (from geneSymbol) ENSMUST00000157550.1 ENSMUST00000157550.2 uc290ahj.1 uc290ahj.2 uc290ahj.1 uc290ahj.2 
ENSMUST00000157555.3 Gm22218 ENSMUST00000157555.3 Gm22218 (from geneSymbol) ENSMUST00000157555.1 ENSMUST00000157555.2 uc288uui.1 uc288uui.2 uc288uui.1 uc288uui.2 
ENSMUST00000157558.4 Gm22215 ENSMUST00000157558.4 Gm22215 (from geneSymbol) ENSMUST00000157558.1 ENSMUST00000157558.2 ENSMUST00000157558.3 uc289nbh.1 uc289nbh.2 uc289nbh.1 uc289nbh.2 
ENSMUST00000157560.3 Scarna2 ENSMUST00000157560.3 Scarna2 (from geneSymbol) AF357344 ENSMUST00000157560.1 ENSMUST00000157560.2 uc012cwd.1 uc012cwd.2 uc012cwd.3 uc012cwd.1 uc012cwd.2 uc012cwd.3 
ENSMUST00000157566.3 Gm23903 ENSMUST00000157566.3 Gm23903 (from geneSymbol) ENSMUST00000157566.1 ENSMUST00000157566.2 uc288xhf.1 uc288xhf.2 uc288xhf.1 uc288xhf.2 
ENSMUST00000157567.3 Gm23904 ENSMUST00000157567.3 Gm23904 (from geneSymbol) ENSMUST00000157567.1 ENSMUST00000157567.2 uc292bua.1 uc292bua.2 uc292bua.1 uc292bua.2 
ENSMUST00000157570.3 Gm23901 ENSMUST00000157570.3 Gm23901 (from geneSymbol) ENSMUST00000157570.1 ENSMUST00000157570.2 uc292rpr.1 uc292rpr.2 uc292rpr.1 uc292rpr.2 
ENSMUST00000157571.3 Gm23902 ENSMUST00000157571.3 Gm23902 (from geneSymbol) ENSMUST00000157571.1 ENSMUST00000157571.2 uc287lln.1 uc287lln.2 uc287lln.1 uc287lln.2 
ENSMUST00000157572.3 Gm24138 ENSMUST00000157572.3 Gm24138 (from geneSymbol) ENSMUST00000157572.1 ENSMUST00000157572.2 uc289wmp.1 uc289wmp.2 uc289wmp.1 uc289wmp.2 
ENSMUST00000157573.3 Gm23906 ENSMUST00000157573.3 Gm23906 (from geneSymbol) ENSMUST00000157573.1 ENSMUST00000157573.2 uc287rdu.1 uc287rdu.2 uc287rdu.1 uc287rdu.2 
ENSMUST00000157576.3 Gm23754 ENSMUST00000157576.3 Gm23754 (from geneSymbol) ENSMUST00000157576.1 ENSMUST00000157576.2 uc288xom.1 uc288xom.2 uc288xom.1 uc288xom.2 
ENSMUST00000157583.3 Gm23751 ENSMUST00000157583.3 Gm23751 (from geneSymbol) ENSMUST00000157583.1 ENSMUST00000157583.2 uc291iyw.1 uc291iyw.2 uc291iyw.1 uc291iyw.2 
ENSMUST00000157587.3 Gm22082 ENSMUST00000157587.3 Gm22082 (from geneSymbol) ENSMUST00000157587.1 ENSMUST00000157587.2 uc289rso.1 uc289rso.2 uc289rso.1 uc289rso.2 
ENSMUST00000157592.4 Gm22079 ENSMUST00000157592.4 Gm22079 (from geneSymbol) ENSMUST00000157592.1 ENSMUST00000157592.2 ENSMUST00000157592.3 uc288jce.1 uc288jce.2 uc288jce.1 uc288jce.2 
ENSMUST00000157593.3 Gm22078 ENSMUST00000157593.3 Gm22078 (from geneSymbol) ENSMUST00000157593.1 ENSMUST00000157593.2 uc290kjx.1 uc290kjx.2 uc290kjx.1 uc290kjx.2 
ENSMUST00000157597.3 Gm22599 ENSMUST00000157597.3 Gm22599 (from geneSymbol) ENSMUST00000157597.1 ENSMUST00000157597.2 uc287yks.1 uc287yks.2 uc287yks.1 uc287yks.2 
ENSMUST00000157599.3 Gm25406 ENSMUST00000157599.3 Gm25406 (from geneSymbol) ENSMUST00000157599.1 ENSMUST00000157599.2 uc289mtf.1 uc289mtf.2 uc289mtf.1 uc289mtf.2 
ENSMUST00000157600.3 Gm22598 ENSMUST00000157600.3 Gm22598 (from geneSymbol) ENSMUST00000157600.1 ENSMUST00000157600.2 uc289bze.1 uc289bze.2 uc289bze.1 uc289bze.2 
ENSMUST00000157602.3 Gm22597 ENSMUST00000157602.3 Gm22597 (from geneSymbol) ENSMUST00000157602.1 ENSMUST00000157602.2 uc289pdt.1 uc289pdt.2 uc289pdt.1 uc289pdt.2 
ENSMUST00000157603.3 Gm22603 ENSMUST00000157603.3 Gm22603 (from geneSymbol) ENSMUST00000157603.1 ENSMUST00000157603.2 uc287yhq.1 uc287yhq.2 uc287yhq.1 uc287yhq.2 
ENSMUST00000157607.3 Gm25429 ENSMUST00000157607.3 Gm25429 (from geneSymbol) ENSMUST00000157607.1 ENSMUST00000157607.2 uc292rjb.1 uc292rjb.2 uc292rjb.1 uc292rjb.2 
ENSMUST00000157611.3 Gm25425 ENSMUST00000157611.3 Gm25425 (from geneSymbol) ENSMUST00000157611.1 ENSMUST00000157611.2 uc292evf.1 uc292evf.2 uc292evf.1 uc292evf.2 
ENSMUST00000157615.3 Gm22915 ENSMUST00000157615.3 Gm22915 (from geneSymbol) ENSMUST00000157615.1 ENSMUST00000157615.2 uc290xdo.1 uc290xdo.2 uc290xdo.1 uc290xdo.2 
ENSMUST00000157616.3 Gm22916 ENSMUST00000157616.3 Gm22916 (from geneSymbol) ENSMUST00000157616.1 ENSMUST00000157616.2 uc291isc.1 uc291isc.2 uc291isc.1 uc291isc.2 
ENSMUST00000157617.3 Gm25913 ENSMUST00000157617.3 Gm25913 (from geneSymbol) ENSMUST00000157617.1 ENSMUST00000157617.2 uc288fuf.1 uc288fuf.2 uc288fuf.1 uc288fuf.2 
ENSMUST00000157619.3 Gm25909 ENSMUST00000157619.3 Gm25909 (from geneSymbol) ENSMUST00000157619.1 ENSMUST00000157619.2 uc289gqf.1 uc289gqf.2 uc289gqf.1 uc289gqf.2 
ENSMUST00000157620.3 Gm25910 ENSMUST00000157620.3 Gm25910 (from geneSymbol) ENSMUST00000157620.1 ENSMUST00000157620.2 uc291fgr.1 uc291fgr.2 uc291fgr.1 uc291fgr.2 
ENSMUST00000157623.3 Mir1969 ENSMUST00000157623.3 microRNA 1969 (from RefSeq NR_035495.1) ENSMUST00000157623.1 ENSMUST00000157623.2 NR_035495 uc012gfn.1 uc012gfn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610494.1 [ECO:0000345] ##Evidence-Data-END## uc012gfn.1 uc012gfn.2 
ENSMUST00000157627.3 Snord13 ENSMUST00000157627.3 small nucleolar RNA, C/D box 13 (from RefSeq NR_028522.2) ENSMUST00000157627.1 ENSMUST00000157627.2 NR_028522 uc057lwx.1 uc057lwx.2 uc057lwx.3 uc057lwx.1 uc057lwx.2 uc057lwx.3 
ENSMUST00000157628.4 Gm24285 ENSMUST00000157628.4 Gm24285 (from geneSymbol) ENSMUST00000157628.1 ENSMUST00000157628.2 ENSMUST00000157628.3 uc287rhz.1 uc287rhz.2 uc287rhz.1 uc287rhz.2 
ENSMUST00000157629.3 Gm24289 ENSMUST00000157629.3 Gm24289 (from geneSymbol) AF357479 ENSMUST00000157629.1 ENSMUST00000157629.2 uc292icq.1 uc292icq.2 uc292icq.1 uc292icq.2 
ENSMUST00000157630.3 Gm24288 ENSMUST00000157630.3 Gm24288 (from geneSymbol) ENSMUST00000157630.1 ENSMUST00000157630.2 uc291xzm.1 uc291xzm.2 uc291xzm.1 uc291xzm.2 
ENSMUST00000157632.3 Gm24286 ENSMUST00000157632.3 Gm24286 (from geneSymbol) ENSMUST00000157632.1 ENSMUST00000157632.2 uc287qhl.1 uc287qhl.2 uc287qhl.1 uc287qhl.2 
ENSMUST00000157633.3 Gm24291 ENSMUST00000157633.3 Gm24291 (from geneSymbol) ENSMUST00000157633.1 ENSMUST00000157633.2 uc292dia.1 uc292dia.2 uc292dia.1 uc292dia.2 
ENSMUST00000157635.3 Gm24780 ENSMUST00000157635.3 Gm24780 (from geneSymbol) ENSMUST00000157635.1 ENSMUST00000157635.2 uc290elk.1 uc290elk.2 uc290elk.1 uc290elk.2 
ENSMUST00000157636.3 Gm24781 ENSMUST00000157636.3 Gm24781 (from geneSymbol) ENSMUST00000157636.1 ENSMUST00000157636.2 uc292buw.1 uc292buw.2 uc292buw.1 uc292buw.2 
ENSMUST00000157640.3 Gm24784 ENSMUST00000157640.3 Gm24784 (from geneSymbol) ENSMUST00000157640.1 ENSMUST00000157640.2 uc291hnj.1 uc291hnj.2 uc291hnj.1 uc291hnj.2 
ENSMUST00000157641.3 Gm24782 ENSMUST00000157641.3 Gm24782 (from geneSymbol) ENSMUST00000157641.1 ENSMUST00000157641.2 uc289rnv.1 uc289rnv.2 uc289rnv.1 uc289rnv.2 
ENSMUST00000157648.3 Gm23123 ENSMUST00000157648.3 Gm23123 (from geneSymbol) ENSMUST00000157648.1 ENSMUST00000157648.2 uc289ipi.1 uc289ipi.2 uc289ipi.1 uc289ipi.2 
ENSMUST00000157650.3 Gm23124 ENSMUST00000157650.3 Gm23124 (from geneSymbol) ENSMUST00000157650.1 ENSMUST00000157650.2 uc292qmz.1 uc292qmz.2 uc292qmz.1 uc292qmz.2 
ENSMUST00000157651.3 Gm23125 ENSMUST00000157651.3 Gm23125 (from geneSymbol) ENSMUST00000157651.1 ENSMUST00000157651.2 uc289nbk.1 uc289nbk.2 uc289nbk.1 uc289nbk.2 
ENSMUST00000157656.3 Gm23585 ENSMUST00000157656.3 Gm23585 (from geneSymbol) DQ558729 ENSMUST00000157656.1 ENSMUST00000157656.2 uc291prk.1 uc291prk.2 uc291prk.1 uc291prk.2 
ENSMUST00000157657.3 Gm23586 ENSMUST00000157657.3 Gm23586 (from geneSymbol) ENSMUST00000157657.1 ENSMUST00000157657.2 uc292qkb.1 uc292qkb.2 uc292qkb.1 uc292qkb.2 
ENSMUST00000157668.3 Gm26411 ENSMUST00000157668.3 Gm26411 (from geneSymbol) ENSMUST00000157668.1 ENSMUST00000157668.2 uc290yzq.1 uc290yzq.2 uc290yzq.1 uc290yzq.2 
ENSMUST00000157671.3 Gm26409 ENSMUST00000157671.3 Gm26409 (from geneSymbol) ENSMUST00000157671.1 ENSMUST00000157671.2 uc292lty.1 uc292lty.2 uc292lty.1 uc292lty.2 
ENSMUST00000157672.4 Gm26408 ENSMUST00000157672.4 Gm26408 (from geneSymbol) ENSMUST00000157672.1 ENSMUST00000157672.2 ENSMUST00000157672.3 uc289wwc.1 uc289wwc.2 uc289wwc.1 uc289wwc.2 
ENSMUST00000157678.4 Gm23382 ENSMUST00000157678.4 Gm23382 (from geneSymbol) ENSMUST00000157678.1 ENSMUST00000157678.2 ENSMUST00000157678.3 uc290pgk.1 uc290pgk.2 uc290pgk.1 uc290pgk.2 
ENSMUST00000157679.3 Gm24504 ENSMUST00000157679.3 Gm24504 (from geneSymbol) ENSMUST00000157679.1 ENSMUST00000157679.2 uc289pjb.1 uc289pjb.2 uc289pjb.1 uc289pjb.2 
ENSMUST00000157682.3 Gm24505 ENSMUST00000157682.3 Gm24505 (from geneSymbol) ENSMUST00000157682.1 ENSMUST00000157682.2 uc291omk.1 uc291omk.2 uc291omk.1 uc291omk.2 
ENSMUST00000157683.3 Gm24507 ENSMUST00000157683.3 Gm24507 (from geneSymbol) ENSMUST00000157683.1 ENSMUST00000157683.2 uc288par.1 uc288par.2 uc288par.1 uc288par.2 
ENSMUST00000157685.3 Gm26183 ENSMUST00000157685.3 Gm26183 (from geneSymbol) ENSMUST00000157685.1 ENSMUST00000157685.2 uc289qzp.1 uc289qzp.2 uc289qzp.1 uc289qzp.2 
ENSMUST00000157686.3 Gm26184 ENSMUST00000157686.3 Gm26184 (from geneSymbol) ENSMUST00000157686.1 ENSMUST00000157686.2 uc291ylg.1 uc291ylg.2 uc291ylg.1 uc291ylg.2 
ENSMUST00000157687.3 Gm26181 ENSMUST00000157687.3 Gm26181 (from geneSymbol) ENSMUST00000157687.1 ENSMUST00000157687.2 uc291znc.1 uc291znc.2 uc291znc.1 uc291znc.2 
ENSMUST00000157688.4 Gm26182 ENSMUST00000157688.4 Gm26182 (from geneSymbol) ENSMUST00000157688.1 ENSMUST00000157688.2 ENSMUST00000157688.3 uc292qgx.1 uc292qgx.2 uc292qgx.1 uc292qgx.2 
ENSMUST00000157693.3 Gm26187 ENSMUST00000157693.3 Gm26187 (from geneSymbol) ENSMUST00000157693.1 ENSMUST00000157693.2 uc287kch.1 uc287kch.2 uc287kch.1 uc287kch.2 
ENSMUST00000157695.3 Gm25665 ENSMUST00000157695.3 Gm25665 (from geneSymbol) ENSMUST00000157695.1 ENSMUST00000157695.2 uc291ynj.1 uc291ynj.2 uc291ynj.1 uc291ynj.2 
ENSMUST00000157698.3 Gm25663 ENSMUST00000157698.3 Gm25663 (from geneSymbol) ENSMUST00000157698.1 ENSMUST00000157698.2 uc287mim.1 uc287mim.2 uc287mim.1 uc287mim.2 
ENSMUST00000157700.4 Gm25668 ENSMUST00000157700.4 Gm25668 (from geneSymbol) ENSMUST00000157700.1 ENSMUST00000157700.2 ENSMUST00000157700.3 uc289azo.1 uc289azo.2 uc289azo.1 uc289azo.2 
ENSMUST00000157704.4 Gm25661 ENSMUST00000157704.4 Gm25661 (from geneSymbol) ENSMUST00000157704.1 ENSMUST00000157704.2 ENSMUST00000157704.3 uc292akj.1 uc292akj.2 uc292akj.1 uc292akj.2 
ENSMUST00000157707.4 Gm22847 ENSMUST00000157707.4 Gm22847 (from geneSymbol) ENSMUST00000157707.1 ENSMUST00000157707.2 ENSMUST00000157707.3 uc290urg.1 uc290urg.2 uc290urg.1 uc290urg.2 
ENSMUST00000157708.4 Gm27396 ENSMUST00000157708.4 Gm27396 (from geneSymbol) ENSMUST00000157708.1 ENSMUST00000157708.2 ENSMUST00000157708.3 uc287gdo.1 uc287gdo.2 uc287gdo.1 uc287gdo.2 
ENSMUST00000157712.3 Gm22845 ENSMUST00000157712.3 Gm22845 (from geneSymbol) ENSMUST00000157712.1 ENSMUST00000157712.2 uc288evt.1 uc288evt.2 uc288evt.1 uc288evt.2 
ENSMUST00000157714.4 Gm22850 ENSMUST00000157714.4 Gm22850 (from geneSymbol) ENSMUST00000157714.1 ENSMUST00000157714.2 ENSMUST00000157714.3 uc290luj.1 uc290luj.2 uc290luj.1 uc290luj.2 
ENSMUST00000157718.3 Gm22339 ENSMUST00000157718.3 Gm22339 (from geneSymbol) ENSMUST00000157718.1 ENSMUST00000157718.2 uc287uqp.1 uc287uqp.2 uc287uqp.1 uc287uqp.2 
ENSMUST00000157719.3 Gm22336 ENSMUST00000157719.3 Gm22336 (from geneSymbol) ENSMUST00000157719.1 ENSMUST00000157719.2 uc292bsx.1 uc292bsx.2 uc292bsx.1 uc292bsx.2 
ENSMUST00000157721.3 Gm22337 ENSMUST00000157721.3 Gm22337 (from geneSymbol) ENSMUST00000157721.1 ENSMUST00000157721.2 uc290ixq.1 uc290ixq.2 uc290ixq.1 uc290ixq.2 
ENSMUST00000157724.3 Gm22335 ENSMUST00000157724.3 Gm22335 (from geneSymbol) ENSMUST00000157724.1 ENSMUST00000157724.2 LF194555 uc290pbn.1 uc290pbn.2 uc290pbn.1 uc290pbn.2 
ENSMUST00000157726.2 Gm24016 ENSMUST00000157726.2 Gm24016 (from geneSymbol) ENSMUST00000157726.1 uc290kzc.1 uc290kzc.2 uc290kzc.1 uc290kzc.2 
ENSMUST00000157727.3 Gm24013 ENSMUST00000157727.3 Gm24013 (from geneSymbol) ENSMUST00000157727.1 ENSMUST00000157727.2 uc287wfm.1 uc287wfm.2 uc287wfm.1 uc287wfm.2 
ENSMUST00000157733.3 Gm24008 ENSMUST00000157733.3 Gm24008 (from geneSymbol) ENSMUST00000157733.1 ENSMUST00000157733.2 uc291hzs.1 uc291hzs.2 uc291hzs.1 uc291hzs.2 
ENSMUST00000157737.3 Gm23498 ENSMUST00000157737.3 Gm23498 (from geneSymbol) ENSMUST00000157737.1 ENSMUST00000157737.2 uc291kew.1 uc291kew.2 uc291kew.1 uc291kew.2 
ENSMUST00000157738.3 Gm23497 ENSMUST00000157738.3 Gm23497 (from geneSymbol) ENSMUST00000157738.1 ENSMUST00000157738.2 uc287ldb.1 uc287ldb.2 uc287ldb.1 uc287ldb.2 
ENSMUST00000157739.4 Gm28020 ENSMUST00000157739.4 Gm28020 (from geneSymbol) ENSMUST00000157739.1 ENSMUST00000157739.2 ENSMUST00000157739.3 uc288yol.1 uc288yol.2 uc288yol.1 uc288yol.2 
ENSMUST00000157745.3 Gm22880 ENSMUST00000157745.3 Gm22880 (from geneSymbol) ENSMUST00000157745.1 ENSMUST00000157745.2 uc289riy.1 uc289riy.2 uc289riy.1 uc289riy.2 
ENSMUST00000157747.3 Gm22881 ENSMUST00000157747.3 Gm22881 (from geneSymbol) ENSMUST00000157747.1 ENSMUST00000157747.2 uc291jsj.1 uc291jsj.2 uc291jsj.1 uc291jsj.2 
ENSMUST00000157748.5 Mir1956 ENSMUST00000157748.5 microRNA 1956 (from RefSeq NR_035481.1) ENSMUST00000157748.1 ENSMUST00000157748.2 ENSMUST00000157748.3 ENSMUST00000157748.4 NR_035481 uc012cym.1 uc012cym.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610484.1 [ECO:0000345] ##Evidence-Data-END## uc012cym.1 uc012cym.2 
ENSMUST00000157749.3 Gm22882 ENSMUST00000157749.3 Gm22882 (from geneSymbol) ENSMUST00000157749.1 ENSMUST00000157749.2 uc291ieb.1 uc291ieb.2 uc291ieb.1 uc291ieb.2 
ENSMUST00000157752.3 Gm25183 ENSMUST00000157752.3 Gm25183 (from geneSymbol) ENSMUST00000157752.1 ENSMUST00000157752.2 uc289bei.1 uc289bei.2 uc289bei.1 uc289bei.2 
ENSMUST00000157753.4 Gm25184 ENSMUST00000157753.4 Gm25184 (from geneSymbol) ENSMUST00000157753.1 ENSMUST00000157753.2 ENSMUST00000157753.3 uc290doh.1 uc290doh.2 uc290doh.1 uc290doh.2 
ENSMUST00000157754.3 Gm25185 ENSMUST00000157754.3 Gm25185 (from geneSymbol) ENSMUST00000157754.1 ENSMUST00000157754.2 uc291hbs.1 uc291hbs.2 uc291hbs.1 uc291hbs.2 
ENSMUST00000157755.3 Gm24686 ENSMUST00000157755.3 Gm24686 (from geneSymbol) ENSMUST00000157755.1 ENSMUST00000157755.2 uc290sxp.1 uc290sxp.2 uc290sxp.1 uc290sxp.2 
ENSMUST00000157758.4 Gm24687 ENSMUST00000157758.4 Gm24687 (from geneSymbol) ENSMUST00000157758.1 ENSMUST00000157758.2 ENSMUST00000157758.3 uc292rhj.1 uc292rhj.2 uc292rhj.1 uc292rhj.2 
ENSMUST00000157762.3 Gm24691 ENSMUST00000157762.3 Gm24691 (from geneSymbol) ENSMUST00000157762.1 ENSMUST00000157762.2 uc291cyg.1 uc291cyg.2 uc291cyg.1 uc291cyg.2 
ENSMUST00000157766.3 Gm26310 ENSMUST00000157766.3 Gm26310 (from geneSymbol) ENSMUST00000157766.1 ENSMUST00000157766.2 uc291cyk.1 uc291cyk.2 uc291cyk.1 uc291cyk.2 
ENSMUST00000157767.3 Gm26307 ENSMUST00000157767.3 Gm26307 (from geneSymbol) ENSMUST00000157767.1 ENSMUST00000157767.2 uc289fmr.1 uc289fmr.2 uc289fmr.1 uc289fmr.2 
ENSMUST00000157769.4 Gm26312 ENSMUST00000157769.4 Gm26312 (from geneSymbol) ENSMUST00000157769.1 ENSMUST00000157769.2 ENSMUST00000157769.3 uc292ogj.1 uc292ogj.2 uc292ogj.1 uc292ogj.2 
ENSMUST00000157773.3 Gm26306 ENSMUST00000157773.3 Gm26306 (from geneSymbol) ENSMUST00000157773.1 ENSMUST00000157773.2 uc292gpa.1 uc292gpa.2 uc292gpa.1 uc292gpa.2 
ENSMUST00000157777.3 Gm25887 ENSMUST00000157777.3 Gm25887 (from geneSymbol) ENSMUST00000157777.1 ENSMUST00000157777.2 uc288uqj.1 uc288uqj.2 uc288uqj.1 uc288uqj.2 
ENSMUST00000157780.4 Gm25886 ENSMUST00000157780.4 Gm25886 (from geneSymbol) ENSMUST00000157780.1 ENSMUST00000157780.2 ENSMUST00000157780.3 uc288wam.1 uc288wam.2 uc288wam.1 uc288wam.2 
ENSMUST00000157782.3 Gm25884 ENSMUST00000157782.3 Gm25884 (from geneSymbol) ENSMUST00000157782.1 ENSMUST00000157782.2 uc287udc.1 uc287udc.2 uc287udc.1 uc287udc.2 
ENSMUST00000157783.3 Gm25881 ENSMUST00000157783.3 Gm25881 (from geneSymbol) ENSMUST00000157783.1 ENSMUST00000157783.2 uc290cil.1 uc290cil.2 uc290cil.1 uc290cil.2 
ENSMUST00000157785.3 Gm24240 ENSMUST00000157785.3 Gm24240 (from geneSymbol) ENSMUST00000157785.1 ENSMUST00000157785.2 uc289ndy.1 uc289ndy.2 uc289ndy.1 uc289ndy.2 
ENSMUST00000157787.3 Gm24241 ENSMUST00000157787.3 Gm24241 (from geneSymbol) ENSMUST00000157787.1 ENSMUST00000157787.2 uc287udh.1 uc287udh.2 uc287udh.1 uc287udh.2 
ENSMUST00000157789.3 Mir1967 ENSMUST00000157789.3 microRNA 1967 (from RefSeq NR_035493.1) ENSMUST00000157789.1 ENSMUST00000157789.2 NR_035493 uc012gmu.1 uc012gmu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610492.1 [ECO:0000345] ##Evidence-Data-END## uc012gmu.1 uc012gmu.2 
ENSMUST00000157793.3 Gm26162 ENSMUST00000157793.3 Gm26162 (from geneSymbol) ENSMUST00000157793.1 ENSMUST00000157793.2 uc290poj.1 uc290poj.2 uc290poj.1 uc290poj.2 
ENSMUST00000157794.3 Gm24236 ENSMUST00000157794.3 Gm24236 (from geneSymbol) ENSMUST00000157794.1 ENSMUST00000157794.2 uc292aev.1 uc292aev.2 uc292aev.1 uc292aev.2 
ENSMUST00000157795.3 Gm22551 ENSMUST00000157795.3 Gm22551 (from geneSymbol) ENSMUST00000157795.1 ENSMUST00000157795.2 uc291ynx.1 uc291ynx.2 uc291ynx.1 uc291ynx.2 
ENSMUST00000157798.3 Gm22554 ENSMUST00000157798.3 Gm22554 (from geneSymbol) ENSMUST00000157798.1 ENSMUST00000157798.2 uc287qne.1 uc287qne.2 uc287qne.1 uc287qne.2 
ENSMUST00000157800.3 Gm24422 ENSMUST00000157800.3 Gm24422 (from geneSymbol) ENSMUST00000157800.1 ENSMUST00000157800.2 uc287xqu.1 uc287xqu.2 uc287xqu.1 uc287xqu.2 
ENSMUST00000157804.4 Gm22557 ENSMUST00000157804.4 Gm22557 (from geneSymbol) ENSMUST00000157804.1 ENSMUST00000157804.2 ENSMUST00000157804.3 uc290xvh.1 uc290xvh.2 uc290xvh.1 uc290xvh.2 
ENSMUST00000157807.4 Gm25384 ENSMUST00000157807.4 Gm25384 (from geneSymbol) ENSMUST00000157807.1 ENSMUST00000157807.2 ENSMUST00000157807.3 uc287llq.1 uc287llq.2 uc287llq.1 uc287llq.2 
ENSMUST00000157810.3 Gm25383 ENSMUST00000157810.3 Gm25383 (from geneSymbol) ENSMUST00000157810.1 ENSMUST00000157810.2 uc288otz.1 uc288otz.2 uc288otz.1 uc288otz.2 
ENSMUST00000157812.4 Gm24198 ENSMUST00000157812.4 Gm24198 (from geneSymbol) ENSMUST00000157812.1 ENSMUST00000157812.2 ENSMUST00000157812.3 LF198496 uc287yfi.1 uc287yfi.2 uc287yfi.1 uc287yfi.2 
ENSMUST00000157813.3 Gm25387 ENSMUST00000157813.3 Gm25387 (from geneSymbol) ENSMUST00000157813.1 ENSMUST00000157813.2 uc287xcg.1 uc287xcg.2 uc287xcg.1 uc287xcg.2 
ENSMUST00000157815.3 Gm23555 ENSMUST00000157815.3 Gm23555 (from geneSymbol) ENSMUST00000157815.1 ENSMUST00000157815.2 uc289pec.1 uc289pec.2 uc289pec.1 uc289pec.2 
ENSMUST00000157816.3 Gm25599 ENSMUST00000157816.3 Gm25599 (from geneSymbol) ENSMUST00000157816.1 ENSMUST00000157816.2 uc288gtz.1 uc288gtz.2 uc288gtz.1 uc288gtz.2 
ENSMUST00000157818.3 Gm23554 ENSMUST00000157818.3 Gm23554 (from geneSymbol) ENSMUST00000157818.1 ENSMUST00000157818.2 uc291ise.1 uc291ise.2 uc291ise.1 uc291ise.2 
ENSMUST00000157819.3 Gm22187 ENSMUST00000157819.3 Gm22187 (from geneSymbol) ENSMUST00000157819.1 ENSMUST00000157819.2 uc290bhd.1 uc290bhd.2 uc290bhd.1 uc290bhd.2 
ENSMUST00000157820.3 Gm23557 ENSMUST00000157820.3 Gm23557 (from geneSymbol) ENSMUST00000157820.1 ENSMUST00000157820.2 LF202107 uc292pkj.1 uc292pkj.2 uc292pkj.1 uc292pkj.2 
ENSMUST00000157822.3 Gm22186 ENSMUST00000157822.3 Gm22186 (from geneSymbol) ENSMUST00000157822.1 ENSMUST00000157822.2 uc287uui.1 uc287uui.2 uc287uui.1 uc287uui.2 
ENSMUST00000157825.3 Gm26369 ENSMUST00000157825.3 Gm26369 (from geneSymbol) ENSMUST00000157825.1 ENSMUST00000157825.2 uc289fax.1 uc289fax.2 uc289fax.1 uc289fax.2 
ENSMUST00000157826.3 Gm26368 ENSMUST00000157826.3 Gm26368 (from geneSymbol) ENSMUST00000157826.1 ENSMUST00000157826.2 LF202328 uc292rtm.1 uc292rtm.2 uc292rtm.1 uc292rtm.2 
ENSMUST00000157829.3 Gm26371 ENSMUST00000157829.3 Gm26371 (from geneSymbol) ENSMUST00000157829.1 ENSMUST00000157829.2 uc289aup.1 uc289aup.2 uc289aup.1 uc289aup.2 
ENSMUST00000157833.3 Gm26373 ENSMUST00000157833.3 Gm26373 (from geneSymbol) ENSMUST00000157833.1 ENSMUST00000157833.2 uc291cux.1 uc291cux.2 uc291cux.1 uc291cux.2 
ENSMUST00000157834.3 Mir1941 ENSMUST00000157834.3 microRNA 1941 (from RefSeq NR_035462.1) ENSMUST00000157834.1 ENSMUST00000157834.2 NR_035462 uc011zzs.1 uc011zzs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011zzs.1 uc011zzs.2 
ENSMUST00000157839.3 Mir1970 ENSMUST00000157839.3 microRNA 1970 (from RefSeq NR_035497.1) ENSMUST00000157839.1 ENSMUST00000157839.2 NR_035497 uc057asv.1 uc057asv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057asv.1 uc057asv.2 
ENSMUST00000157840.3 Gm24745 ENSMUST00000157840.3 Gm24745 (from geneSymbol) ENSMUST00000157840.1 ENSMUST00000157840.2 uc287ush.1 uc287ush.2 uc287ush.1 uc287ush.2 
ENSMUST00000157843.4 Gm24750 ENSMUST00000157843.4 Gm24750 (from geneSymbol) ENSMUST00000157843.1 ENSMUST00000157843.2 ENSMUST00000157843.3 uc288gqx.1 uc288gqx.2 uc288gqx.1 uc288gqx.2 
ENSMUST00000157844.3 Gm24751 ENSMUST00000157844.3 Gm24751 (from geneSymbol) ENSMUST00000157844.1 ENSMUST00000157844.2 uc288xwc.1 uc288xwc.2 uc288xwc.1 uc288xwc.2 
ENSMUST00000157846.3 Gm23080 ENSMUST00000157846.3 Gm23080 (from geneSymbol) ENSMUST00000157846.1 ENSMUST00000157846.2 uc289ekq.1 uc289ekq.2 uc289ekq.1 uc289ekq.2 
ENSMUST00000157847.3 Gm23079 ENSMUST00000157847.3 Gm23079 (from geneSymbol) ENSMUST00000157847.1 ENSMUST00000157847.2 uc291irq.1 uc291irq.2 uc291irq.1 uc291irq.2 
ENSMUST00000157851.3 Gm23083 ENSMUST00000157851.3 Gm23083 (from geneSymbol) ENSMUST00000157851.1 ENSMUST00000157851.2 uc289fqy.1 uc289fqy.2 uc289fqy.1 uc289fqy.2 
ENSMUST00000157852.3 Gm23082 ENSMUST00000157852.3 Gm23082 (from geneSymbol) ENSMUST00000157852.1 ENSMUST00000157852.2 uc292mwv.1 uc292mwv.2 uc292mwv.1 uc292mwv.2 
ENSMUST00000157853.3 Mir1946b ENSMUST00000157853.3 microRNA 1946b (from RefSeq NR_035496.1) ENSMUST00000157853.1 ENSMUST00000157853.2 NR_035496 uc057aoa.1 uc057aoa.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057aoa.1 uc057aoa.2 
ENSMUST00000157854.3 Gm23077 ENSMUST00000157854.3 Gm23077 (from geneSymbol) ENSMUST00000157854.1 ENSMUST00000157854.2 uc290iil.1 uc290iil.2 uc290iil.1 uc290iil.2 
ENSMUST00000157855.3 Gm24508 ENSMUST00000157855.3 Gm24508 (from geneSymbol) ENSMUST00000157855.1 ENSMUST00000157855.2 uc289nqc.1 uc289nqc.2 uc289nqc.1 uc289nqc.2 
ENSMUST00000157856.4 Gm23644 ENSMUST00000157856.4 Gm23644 (from geneSymbol) ENSMUST00000157856.1 ENSMUST00000157856.2 ENSMUST00000157856.3 uc290gaa.1 uc290gaa.2 uc290gaa.1 uc290gaa.2 
ENSMUST00000157857.3 Gm23641 ENSMUST00000157857.3 Gm23641 (from geneSymbol) ENSMUST00000157857.1 ENSMUST00000157857.2 uc291cce.1 uc291cce.2 uc291cce.1 uc291cce.2 
ENSMUST00000157859.4 Gm23592 ENSMUST00000157859.4 Gm23592 (from geneSymbol) ENSMUST00000157859.1 ENSMUST00000157859.2 ENSMUST00000157859.3 uc290dtm.1 uc290dtm.2 uc290dtm.1 uc290dtm.2 
ENSMUST00000157865.3 Gm24400 ENSMUST00000157865.3 Gm24400 (from geneSymbol) ENSMUST00000157865.1 ENSMUST00000157865.2 uc289scj.1 uc289scj.2 uc289scj.1 uc289scj.2 
ENSMUST00000157866.3 Mir1953 ENSMUST00000157866.3 microRNA 1953 (from RefSeq NR_035478.1) ENSMUST00000157866.1 ENSMUST00000157866.2 NR_035478 uc012cfz.1 uc012cfz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610480.1 [ECO:0000345] ##Evidence-Data-END## uc012cfz.1 uc012cfz.2 
ENSMUST00000157868.3 Gm24401 ENSMUST00000157868.3 Gm24401 (from geneSymbol) ENSMUST00000157868.1 ENSMUST00000157868.2 uc289oui.1 uc289oui.2 uc289oui.1 uc289oui.2 
ENSMUST00000157869.4 Gm24399 ENSMUST00000157869.4 Gm24399 (from geneSymbol) ENSMUST00000157869.1 ENSMUST00000157869.2 ENSMUST00000157869.3 LF194973 uc290vxl.1 uc290vxl.2 uc290vxl.1 uc290vxl.2 
ENSMUST00000157870.3 Gm24398 ENSMUST00000157870.3 Gm24398 (from geneSymbol) ENSMUST00000157870.1 ENSMUST00000157870.2 uc287wys.1 uc287wys.2 uc287wys.1 uc287wys.2 
ENSMUST00000157874.4 Gm22654 ENSMUST00000157874.4 Gm22654 (from geneSymbol) ENSMUST00000157874.1 ENSMUST00000157874.2 ENSMUST00000157874.3 uc289lyt.1 uc289lyt.2 uc289lyt.1 uc289lyt.2 
ENSMUST00000157876.3 Gm22788 ENSMUST00000157876.3 Gm22788 (from geneSymbol) ENSMUST00000157876.1 ENSMUST00000157876.2 uc289opf.1 uc289opf.2 uc289opf.1 uc289opf.2 
ENSMUST00000157879.4 Gm26490 ENSMUST00000157879.4 Gm26490 (from geneSymbol) ENSMUST00000157879.1 ENSMUST00000157879.2 ENSMUST00000157879.3 uc290nsj.1 uc290nsj.2 uc290nsj.1 uc290nsj.2 
ENSMUST00000157880.3 Gm26489 ENSMUST00000157880.3 Gm26489 (from geneSymbol) ENSMUST00000157880.1 ENSMUST00000157880.2 uc290cxb.1 uc290cxb.2 uc290cxb.1 uc290cxb.2 
ENSMUST00000157881.3 Gm24409 ENSMUST00000157881.3 Gm24409 (from geneSymbol) ENSMUST00000157881.1 ENSMUST00000157881.2 uc290aat.1 uc290aat.2 uc290aat.1 uc290aat.2 
ENSMUST00000157884.3 Gm22789 ENSMUST00000157884.3 Gm22789 (from geneSymbol) ENSMUST00000157884.1 ENSMUST00000157884.2 uc287wrt.1 uc287wrt.2 uc287wrt.1 uc287wrt.2 
ENSMUST00000157885.3 Gm23036 ENSMUST00000157885.3 Gm23036 (from geneSymbol) ENSMUST00000157885.1 ENSMUST00000157885.2 uc287kut.1 uc287kut.2 uc287kut.1 uc287kut.2 
ENSMUST00000157886.4 Gm24435 ENSMUST00000157886.4 Gm24435 (from geneSymbol) ENSMUST00000157886.1 ENSMUST00000157886.2 ENSMUST00000157886.3 uc290hwl.1 uc290hwl.2 uc290hwl.1 uc290hwl.2 
ENSMUST00000157887.3 Gm24467 ENSMUST00000157887.3 Gm24467 (from geneSymbol) ENSMUST00000157887.1 ENSMUST00000157887.2 uc289vvx.1 uc289vvx.2 uc289vvx.1 uc289vvx.2 
ENSMUST00000157890.4 Gm23043 ENSMUST00000157890.4 Gm23043 (from geneSymbol) ENSMUST00000157890.1 ENSMUST00000157890.2 ENSMUST00000157890.3 uc290mrz.1 uc290mrz.2 uc290mrz.1 uc290mrz.2 
ENSMUST00000157891.3 Gm23044 ENSMUST00000157891.3 Gm23044 (from geneSymbol) ENSMUST00000157891.1 ENSMUST00000157891.2 LF197919 uc287pou.1 uc287pou.2 uc287pou.1 uc287pou.2 
ENSMUST00000157892.3 Gm24437 ENSMUST00000157892.3 Gm24437 (from geneSymbol) ENSMUST00000157892.1 ENSMUST00000157892.2 uc289elf.1 uc289elf.2 uc289elf.1 uc289elf.2 
ENSMUST00000157896.3 Gm26088 ENSMUST00000157896.3 Gm26088 (from geneSymbol) ENSMUST00000157896.1 ENSMUST00000157896.2 uc288osu.1 uc288osu.2 uc288osu.1 uc288osu.2 
ENSMUST00000157899.3 Snord2 ENSMUST00000157899.3 small nucleolar RNA, C/D box 2 (from RefSeq NR_030705.1) ENSMUST00000157899.1 ENSMUST00000157899.2 NR_030705 uc289dtf.1 uc289dtf.2 uc289dtf.1 uc289dtf.2 
ENSMUST00000157900.3 Gm26085 ENSMUST00000157900.3 Gm26085 (from geneSymbol) ENSMUST00000157900.1 ENSMUST00000157900.2 uc289sid.1 uc289sid.2 uc289sid.1 uc289sid.2 
ENSMUST00000157901.2 Gm26087 ENSMUST00000157901.2 Gm26087 (from geneSymbol) ENSMUST00000157901.1 uc290lul.1 uc290lul.2 uc290lul.1 uc290lul.2 
ENSMUST00000157903.4 Gm26084 ENSMUST00000157903.4 Gm26084 (from geneSymbol) ENSMUST00000157903.1 ENSMUST00000157903.2 ENSMUST00000157903.3 uc290lxe.1 uc290lxe.2 uc290lxe.1 uc290lxe.2 
ENSMUST00000157905.4 Gm23280 ENSMUST00000157905.4 Gm23280 (from geneSymbol) ENSMUST00000157905.1 ENSMUST00000157905.2 ENSMUST00000157905.3 uc292pea.1 uc292pea.2 uc292pea.1 uc292pea.2 
ENSMUST00000157908.4 Gm24998 ENSMUST00000157908.4 Gm24998 (from geneSymbol) ENSMUST00000157908.1 ENSMUST00000157908.2 ENSMUST00000157908.3 uc288siv.1 uc288siv.2 uc288siv.1 uc288siv.2 
ENSMUST00000157911.3 Gm23278 ENSMUST00000157911.3 Gm23278 (from geneSymbol) ENSMUST00000157911.1 ENSMUST00000157911.2 uc288vzn.1 uc288vzn.2 uc288vzn.1 uc288vzn.2 
ENSMUST00000157913.3 Gm23276 ENSMUST00000157913.3 Gm23276 (from geneSymbol) ENSMUST00000157913.1 ENSMUST00000157913.2 uc288wcp.1 uc288wcp.2 uc288wcp.1 uc288wcp.2 
ENSMUST00000157914.3 Gm23277 ENSMUST00000157914.3 Gm23277 (from geneSymbol) ENSMUST00000157914.1 ENSMUST00000157914.2 uc292qht.1 uc292qht.2 uc292qht.1 uc292qht.2 
ENSMUST00000157916.3 Gm24963 ENSMUST00000157916.3 Gm24963 (from geneSymbol) ENSMUST00000157916.1 ENSMUST00000157916.2 uc290dys.1 uc290dys.2 uc290dys.1 uc290dys.2 
ENSMUST00000157919.3 Mir1945 ENSMUST00000157919.3 microRNA 1945 (from RefSeq NR_035466.1) ENSMUST00000157919.1 ENSMUST00000157919.2 NR_035466 uc012abe.1 uc012abe.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610469.1 [ECO:0000345] ##Evidence-Data-END## uc012abe.1 uc012abe.2 
ENSMUST00000157920.4 Gm25982 ENSMUST00000157920.4 Gm25982 (from geneSymbol) ENSMUST00000157920.1 ENSMUST00000157920.2 ENSMUST00000157920.3 uc290spr.1 uc290spr.2 uc290spr.1 uc290spr.2 
ENSMUST00000157922.4 Gm24965 ENSMUST00000157922.4 Gm24965 (from geneSymbol) ENSMUST00000157922.1 ENSMUST00000157922.2 ENSMUST00000157922.3 uc290lnf.1 uc290lnf.2 uc290lnf.1 uc290lnf.2 
ENSMUST00000157925.3 Gm22099 ENSMUST00000157925.3 Gm22099 (from geneSymbol) ENSMUST00000157925.1 ENSMUST00000157925.2 uc292hwq.1 uc292hwq.2 uc292hwq.1 uc292hwq.2 
ENSMUST00000157926.3 Gm22100 ENSMUST00000157926.3 Gm22100 (from geneSymbol) ENSMUST00000157926.1 ENSMUST00000157926.2 uc290obi.1 uc290obi.2 uc290obi.1 uc290obi.2 
ENSMUST00000157927.3 Mir1957a ENSMUST00000157927.3 Mir1957a (from geneSymbol) ENSMUST00000157927.1 ENSMUST00000157927.2 uc057ljz.1 uc057ljz.2 uc057ljz.1 uc057ljz.2 
ENSMUST00000157933.3 Gm22506 ENSMUST00000157933.3 Gm22506 (from geneSymbol) ENSMUST00000157933.1 ENSMUST00000157933.2 uc289rkn.1 uc289rkn.2 uc289rkn.1 uc289rkn.2 
ENSMUST00000157934.3 Mir1981 ENSMUST00000157934.3 microRNA 1981 (from RefSeq NR_035502.1) ENSMUST00000157934.1 ENSMUST00000157934.2 NR_035502 uc011wxx.1 uc011wxx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610504.1 [ECO:0000345] ##Evidence-Data-END## uc011wxx.1 uc011wxx.2 
ENSMUST00000157938.3 Gm23779 ENSMUST00000157938.3 Gm23779 (from geneSymbol) ENSMUST00000157938.1 ENSMUST00000157938.2 uc288lev.1 uc288lev.2 uc288lev.1 uc288lev.2 
ENSMUST00000157950.3 Gm24537 ENSMUST00000157950.3 Gm24537 (from geneSymbol) ENSMUST00000157950.1 ENSMUST00000157950.2 uc291kvz.1 uc291kvz.2 uc291kvz.1 uc291kvz.2 
ENSMUST00000157952.3 Gm25456 ENSMUST00000157952.3 Gm25456 (from geneSymbol) ENSMUST00000157952.1 ENSMUST00000157952.2 uc292ldq.1 uc292ldq.2 uc292ldq.1 uc292ldq.2 
ENSMUST00000157953.3 Gm25459 ENSMUST00000157953.3 Gm25459 (from geneSymbol) ENSMUST00000157953.1 ENSMUST00000157953.2 uc290tmf.1 uc290tmf.2 uc290tmf.1 uc290tmf.2 
ENSMUST00000157954.3 Gm25460 ENSMUST00000157954.3 Gm25460 (from geneSymbol) ENSMUST00000157954.1 ENSMUST00000157954.2 uc287mjj.1 uc287mjj.2 uc287mjj.1 uc287mjj.2 
ENSMUST00000157957.3 Gm22966 ENSMUST00000157957.3 Gm22966 (from geneSymbol) ENSMUST00000157957.1 ENSMUST00000157957.2 uc287mka.1 uc287mka.2 uc287mka.1 uc287mka.2 
ENSMUST00000157958.3 Gm22965 ENSMUST00000157958.3 Gm22965 (from geneSymbol) ENSMUST00000157958.1 ENSMUST00000157958.2 uc290zkx.1 uc290zkx.2 uc290zkx.1 uc290zkx.2 
ENSMUST00000157969.3 Gm23965 ENSMUST00000157969.3 Gm23965 (from geneSymbol) ENSMUST00000157969.1 ENSMUST00000157969.2 uc287kuy.1 uc287kuy.2 uc287kuy.1 uc287kuy.2 
ENSMUST00000157978.4 Gm24192 ENSMUST00000157978.4 Gm24192 (from geneSymbol) ENSMUST00000157978.1 ENSMUST00000157978.2 ENSMUST00000157978.3 uc287xkw.1 uc287xkw.2 uc287xkw.1 uc287xkw.2 
ENSMUST00000157981.3 Mir1951 ENSMUST00000157981.3 microRNA 1951 (from RefSeq NR_035476.1) ENSMUST00000157981.1 ENSMUST00000157981.2 NR_035476 uc012cbf.1 uc012cbf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610479.1 [ECO:0000345] ##Evidence-Data-END## uc012cbf.1 uc012cbf.2 
ENSMUST00000157988.4 Gm23411 ENSMUST00000157988.4 Gm23411 (from geneSymbol) ENSMUST00000157988.1 ENSMUST00000157988.2 ENSMUST00000157988.3 uc289oph.1 uc289oph.2 uc289oph.1 uc289oph.2 
ENSMUST00000157991.3 Gm26000 ENSMUST00000157991.3 Gm26000 (from geneSymbol) ENSMUST00000157991.1 ENSMUST00000157991.2 uc292poy.1 uc292poy.2 uc292poy.1 uc292poy.2 
ENSMUST00000157995.3 Gm23032 ENSMUST00000157995.3 Gm23032 (from geneSymbol) ENSMUST00000157995.1 ENSMUST00000157995.2 uc287hav.1 uc287hav.2 uc287hav.1 uc287hav.2 
ENSMUST00000157996.3 Gm23033 ENSMUST00000157996.3 Gm23033 (from geneSymbol) ENSMUST00000157996.1 ENSMUST00000157996.2 uc288xiq.1 uc288xiq.2 uc288xiq.1 uc288xiq.2 
ENSMUST00000157997.4 Gm23316 ENSMUST00000157997.4 Gm23316 (from geneSymbol) ENSMUST00000157997.1 ENSMUST00000157997.2 ENSMUST00000157997.3 uc292ewk.1 uc292ewk.2 uc292ewk.1 uc292ewk.2 
ENSMUST00000157998.3 Gm23031 ENSMUST00000157998.3 Gm23031 (from geneSymbol) ENSMUST00000157998.1 ENSMUST00000157998.2 LF195027 uc290xbm.1 uc290xbm.2 uc290xbm.1 uc290xbm.2 
ENSMUST00000158000.3 Gm23318 ENSMUST00000158000.3 Gm23318 (from geneSymbol) ENSMUST00000158000.1 ENSMUST00000158000.2 uc290rva.1 uc290rva.2 uc290rva.1 uc290rva.2 
ENSMUST00000158001.5 Gm23034 ENSMUST00000158001.5 Gm23034 (from geneSymbol) ENSMUST00000158001.1 ENSMUST00000158001.2 ENSMUST00000158001.3 ENSMUST00000158001.4 uc292lis.1 uc292lis.2 uc292lis.1 uc292lis.2 
ENSMUST00000158002.4 Gm23035 ENSMUST00000158002.4 Gm23035 (from geneSymbol) ENSMUST00000158002.1 ENSMUST00000158002.2 ENSMUST00000158002.3 uc291hgi.1 uc291hgi.2 uc291hgi.1 uc291hgi.2 
ENSMUST00000158003.4 Gm23315 ENSMUST00000158003.4 Gm23315 (from geneSymbol) ENSMUST00000158003.1 ENSMUST00000158003.2 ENSMUST00000158003.3 uc289wdz.1 uc289wdz.2 uc289wdz.1 uc289wdz.2 
ENSMUST00000158005.4 Gm22312 ENSMUST00000158005.4 Gm22312 (from geneSymbol) ENSMUST00000158005.1 ENSMUST00000158005.2 ENSMUST00000158005.3 uc291hgb.1 uc291hgb.2 uc291hgb.1 uc291hgb.2 
ENSMUST00000158008.3 Gm22313 ENSMUST00000158008.3 Gm22313 (from geneSymbol) ENSMUST00000158008.1 ENSMUST00000158008.2 uc289ysi.1 uc289ysi.2 uc289ysi.1 uc289ysi.2 
ENSMUST00000158009.3 Gm24958 ENSMUST00000158009.3 Gm24958 (from geneSymbol) ENSMUST00000158009.1 ENSMUST00000158009.2 uc287wjd.1 uc287wjd.2 uc287wjd.1 uc287wjd.2 
ENSMUST00000158010.3 Gm22315 ENSMUST00000158010.3 Gm22315 (from geneSymbol) ENSMUST00000158010.1 ENSMUST00000158010.2 uc292itv.1 uc292itv.2 uc292itv.1 uc292itv.2 
ENSMUST00000158013.3 Gm25846 ENSMUST00000158013.3 Gm25846 (from geneSymbol) ENSMUST00000158013.1 ENSMUST00000158013.2 uc290fzi.1 uc290fzi.2 uc290fzi.1 uc290fzi.2 
ENSMUST00000158014.3 Mir1955 ENSMUST00000158014.3 microRNA 1955 (from RefSeq NR_035480.1) ENSMUST00000158014.1 ENSMUST00000158014.2 NR_035480 uc012bzn.1 uc012bzn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610482.1 [ECO:0000345] ##Evidence-Data-END## uc012bzn.1 uc012bzn.2 
ENSMUST00000158015.3 Gm26482 ENSMUST00000158015.3 Gm26482 (from geneSymbol) ENSMUST00000158015.1 ENSMUST00000158015.2 uc291qji.1 uc291qji.2 uc291qji.1 uc291qji.2 
ENSMUST00000158019.4 Gm26485 ENSMUST00000158019.4 Gm26485 (from geneSymbol) ENSMUST00000158019.1 ENSMUST00000158019.2 ENSMUST00000158019.3 uc290dyq.1 uc290dyq.2 uc290dyq.1 uc290dyq.2 
ENSMUST00000158022.3 Gm26487 ENSMUST00000158022.3 Gm26487 (from geneSymbol) ENSMUST00000158022.1 ENSMUST00000158022.2 uc292oii.1 uc292oii.2 uc292oii.1 uc292oii.2 
ENSMUST00000158024.3 Gm26262 ENSMUST00000158024.3 Gm26262 (from geneSymbol) ENSMUST00000158024.1 ENSMUST00000158024.2 uc289paa.1 uc289paa.2 uc289paa.1 uc289paa.2 
ENSMUST00000158026.3 Gm24853 ENSMUST00000158026.3 Gm24853 (from geneSymbol) ENSMUST00000158026.1 ENSMUST00000158026.2 uc288hop.1 uc288hop.2 uc288hop.1 uc288hop.2 
ENSMUST00000158028.3 Gm24851 ENSMUST00000158028.3 Gm24851 (from geneSymbol) ENSMUST00000158028.1 ENSMUST00000158028.2 uc290fgb.1 uc290fgb.2 uc290fgb.1 uc290fgb.2 
ENSMUST00000158029.3 Gm24850 ENSMUST00000158029.3 Gm24850 (from geneSymbol) ENSMUST00000158029.1 ENSMUST00000158029.2 uc287xcf.1 uc287xcf.2 uc287xcf.1 uc287xcf.2 
ENSMUST00000158031.3 Gm24848 ENSMUST00000158031.3 Gm24848 (from geneSymbol) ENSMUST00000158031.1 ENSMUST00000158031.2 uc289pir.1 uc289pir.2 uc289pir.1 uc289pir.2 
ENSMUST00000158033.3 Gm24846 ENSMUST00000158033.3 Gm24846 (from geneSymbol) AK137967 ENSMUST00000158033.1 ENSMUST00000158033.2 uc291ttl.1 uc291ttl.2 uc291ttl.1 uc291ttl.2 
ENSMUST00000158038.3 Gm26065 ENSMUST00000158038.3 Gm26065 (from geneSymbol) ENSMUST00000158038.1 ENSMUST00000158038.2 uc292pkc.1 uc292pkc.2 uc292pkc.1 uc292pkc.2 
ENSMUST00000158043.3 Gm25335 ENSMUST00000158043.3 Gm25335 (from geneSymbol) ENSMUST00000158043.1 ENSMUST00000158043.2 uc290tim.1 uc290tim.2 uc290tim.1 uc290tim.2 
ENSMUST00000158044.4 Gm25336 ENSMUST00000158044.4 Gm25336 (from geneSymbol) ENSMUST00000158044.1 ENSMUST00000158044.2 ENSMUST00000158044.3 uc287mrv.1 uc287mrv.2 uc287mrv.1 uc287mrv.2 
ENSMUST00000158047.3 Gm23664 ENSMUST00000158047.3 Gm23664 (from geneSymbol) ENSMUST00000158047.1 ENSMUST00000158047.2 uc287vlp.1 uc287vlp.2 uc287vlp.1 uc287vlp.2 
ENSMUST00000158050.4 Rprl1 ENSMUST00000158050.4 Rprl1 (from geneSymbol) ENSMUST00000158050.1 ENSMUST00000158050.2 ENSMUST00000158050.3 uc291fkq.1 uc291fkq.2 uc291fkq.1 uc291fkq.2 
ENSMUST00000158053.3 Gm23666 ENSMUST00000158053.3 Gm23666 (from geneSymbol) ENSMUST00000158053.1 ENSMUST00000158053.2 uc291zwv.1 uc291zwv.2 uc291zwv.1 uc291zwv.2 
ENSMUST00000158054.3 Gm23665 ENSMUST00000158054.3 Gm23665 (from geneSymbol) ENSMUST00000158054.1 ENSMUST00000158054.2 uc288xyr.1 uc288xyr.2 uc288xyr.1 uc288xyr.2 
ENSMUST00000158059.3 Gm23994 ENSMUST00000158059.3 Gm23994 (from geneSymbol) ENSMUST00000158059.1 ENSMUST00000158059.2 uc289fuy.1 uc289fuy.2 uc289fuy.1 uc289fuy.2 
ENSMUST00000158060.3 Gm23995 ENSMUST00000158060.3 Gm23995 (from geneSymbol) DQ719817 ENSMUST00000158060.1 ENSMUST00000158060.2 uc291bqd.1 uc291bqd.2 uc291bqd.1 uc291bqd.2 
ENSMUST00000158062.3 Gm23996 ENSMUST00000158062.3 Gm23996 (from geneSymbol) ENSMUST00000158062.1 ENSMUST00000158062.2 uc287vpr.1 uc287vpr.2 uc287vpr.1 uc287vpr.2 
ENSMUST00000158063.3 Gm24000 ENSMUST00000158063.3 Gm24000 (from geneSymbol) ENSMUST00000158063.1 ENSMUST00000158063.2 uc287wnr.1 uc287wnr.2 uc287wnr.1 uc287wnr.2 
ENSMUST00000158064.3 Scarna17 ENSMUST00000158064.3 small Cajal body-specific RNA 17 (from RefSeq NR_028560.1) ENSMUST00000158064.1 ENSMUST00000158064.2 NR_028560 uc012bey.1 uc012bey.2 uc012bey.3 uc012bey.1 uc012bey.2 uc012bey.3 
ENSMUST00000158066.3 Gm22331 ENSMUST00000158066.3 Gm22331 (from geneSymbol) ENSMUST00000158066.1 ENSMUST00000158066.2 uc287kzz.1 uc287kzz.2 uc287kzz.1 uc287kzz.2 
ENSMUST00000158067.3 Gm23838 ENSMUST00000158067.3 Gm23838 (from geneSymbol) ENSMUST00000158067.1 ENSMUST00000158067.2 uc290sxm.1 uc290sxm.2 uc290sxm.1 uc290sxm.2 
ENSMUST00000158068.3 Gm22330 ENSMUST00000158068.3 Gm22330 (from geneSymbol) ENSMUST00000158068.1 ENSMUST00000158068.2 uc288ltk.1 uc288ltk.2 uc288ltk.1 uc288ltk.2 
ENSMUST00000158070.3 Gm22334 ENSMUST00000158070.3 Gm22334 (from geneSymbol) ENSMUST00000158070.1 ENSMUST00000158070.2 LF193699 uc290bsk.1 uc290bsk.2 uc290bsk.1 uc290bsk.2 
ENSMUST00000158071.3 Gm22333 ENSMUST00000158071.3 Gm22333 (from geneSymbol) ENSMUST00000158071.1 ENSMUST00000158071.2 uc290tre.1 uc290tre.2 uc290tre.1 uc290tre.2 
ENSMUST00000158072.4 Gm22332 ENSMUST00000158072.4 Gm22332 (from geneSymbol) ENSMUST00000158072.1 ENSMUST00000158072.2 ENSMUST00000158072.3 uc292ols.1 uc292ols.2 uc292ols.1 uc292ols.2 
ENSMUST00000158079.4 Gm25550 ENSMUST00000158079.4 Gm25550 (from geneSymbol) ENSMUST00000158079.1 ENSMUST00000158079.2 ENSMUST00000158079.3 uc288xcm.1 uc288xcm.2 uc288xcm.1 uc288xcm.2 
ENSMUST00000158080.3 Gm25549 ENSMUST00000158080.3 Gm25549 (from geneSymbol) ENSMUST00000158080.1 ENSMUST00000158080.2 uc287loc.1 uc287loc.2 uc287loc.1 uc287loc.2 
ENSMUST00000158081.4 Gm25552 ENSMUST00000158081.4 Gm25552 (from geneSymbol) ENSMUST00000158081.1 ENSMUST00000158081.2 ENSMUST00000158081.3 uc292nhw.1 uc292nhw.2 uc292nhw.1 uc292nhw.2 
ENSMUST00000158083.4 Gm25558 ENSMUST00000158083.4 Gm25558 (from geneSymbol) ENSMUST00000158083.1 ENSMUST00000158083.2 ENSMUST00000158083.3 LF204934 uc292hfc.1 uc292hfc.2 uc292hfc.1 uc292hfc.2 
ENSMUST00000158087.3 Gm22728 ENSMUST00000158087.3 Gm22728 (from geneSymbol) ENSMUST00000158087.1 ENSMUST00000158087.2 uc290xao.1 uc290xao.2 uc290xao.1 uc290xao.2 
ENSMUST00000158090.3 Gm22727 ENSMUST00000158090.3 Gm22727 (from geneSymbol) ENSMUST00000158090.1 ENSMUST00000158090.2 uc287mdq.1 uc287mdq.2 uc287mdq.1 uc287mdq.2 
ENSMUST00000158091.3 Gm22724 ENSMUST00000158091.3 Gm22724 (from geneSymbol) ENSMUST00000158091.1 ENSMUST00000158091.2 uc291irn.1 uc291irn.2 uc291irn.1 uc291irn.2 
ENSMUST00000158092.4 Gm22725 ENSMUST00000158092.4 Gm22725 (from geneSymbol) ENSMUST00000158092.1 ENSMUST00000158092.2 ENSMUST00000158092.3 uc288vml.1 uc288vml.2 uc288vml.1 uc288vml.2 
ENSMUST00000158093.4 Gm22732 ENSMUST00000158093.4 Gm22732 (from geneSymbol) ENSMUST00000158093.1 ENSMUST00000158093.2 ENSMUST00000158093.3 uc290ltv.1 uc290ltv.2 uc290ltv.1 uc290ltv.2 
ENSMUST00000158094.4 Gm22733 ENSMUST00000158094.4 Gm22733 (from geneSymbol) ENSMUST00000158094.1 ENSMUST00000158094.2 ENSMUST00000158094.3 uc288adq.1 uc288adq.2 uc288adq.1 uc288adq.2 
ENSMUST00000158096.5 Gm22212 ENSMUST00000158096.5 Gm22212 (from geneSymbol) ENSMUST00000158096.1 ENSMUST00000158096.2 ENSMUST00000158096.3 ENSMUST00000158096.4 uc291ezz.1 uc291ezz.2 uc291ezz.1 uc291ezz.2 
ENSMUST00000158101.3 Gm22210 ENSMUST00000158101.3 Gm22210 (from geneSymbol) ENSMUST00000158101.1 ENSMUST00000158101.2 uc289piq.1 uc289piq.2 uc289piq.1 uc289piq.2 
ENSMUST00000158105.3 Gm23892 ENSMUST00000158105.3 Gm23892 (from geneSymbol) ENSMUST00000158105.1 ENSMUST00000158105.2 uc287pry.1 uc287pry.2 uc287pry.1 uc287pry.2 
ENSMUST00000158108.4 Gm23895 ENSMUST00000158108.4 Gm23895 (from geneSymbol) ENSMUST00000158108.1 ENSMUST00000158108.2 ENSMUST00000158108.3 uc289psr.1 uc289psr.2 uc289psr.1 uc289psr.2 
ENSMUST00000158109.3 Gm23896 ENSMUST00000158109.3 Gm23896 (from geneSymbol) ENSMUST00000158109.1 ENSMUST00000158109.2 uc290vps.1 uc290vps.2 uc290vps.1 uc290vps.2 
ENSMUST00000158110.4 Gm23897 ENSMUST00000158110.4 Gm23897 (from geneSymbol) ENSMUST00000158110.1 ENSMUST00000158110.2 ENSMUST00000158110.3 uc290fqw.1 uc290fqw.2 uc290fqw.1 uc290fqw.2 
ENSMUST00000158113.5 Gm55858 ENSMUST00000158113.5 Gm55858 (from geneSymbol) ENSMUST00000158113.1 ENSMUST00000158113.2 ENSMUST00000158113.3 ENSMUST00000158113.4 uc290nwy.1 uc290nwy.2 uc290nwy.1 uc290nwy.2 
ENSMUST00000158114.3 Gm23891 ENSMUST00000158114.3 Gm23891 (from geneSymbol) ENSMUST00000158114.1 ENSMUST00000158114.2 uc290fad.1 uc290fad.2 uc290fad.1 uc290fad.2 
ENSMUST00000158115.3 Gm23220 ENSMUST00000158115.3 Gm23220 (from geneSymbol) ENSMUST00000158115.1 ENSMUST00000158115.2 uc288zuo.1 uc288zuo.2 uc288zuo.1 uc288zuo.2 
ENSMUST00000158119.3 Gm23223 ENSMUST00000158119.3 Gm23223 (from geneSymbol) ENSMUST00000158119.1 ENSMUST00000158119.2 uc287rjy.1 uc287rjy.2 uc287rjy.1 uc287rjy.2 
ENSMUST00000158121.3 Gm23225 ENSMUST00000158121.3 Gm23225 (from geneSymbol) ENSMUST00000158121.1 ENSMUST00000158121.2 uc288wau.1 uc288wau.2 uc288wau.1 uc288wau.2 
ENSMUST00000158123.3 Gm23219 ENSMUST00000158123.3 Gm23219 (from geneSymbol) ENSMUST00000158123.1 ENSMUST00000158123.2 uc288app.1 uc288app.2 uc288app.1 uc288app.2 
ENSMUST00000158125.3 Gm24901 ENSMUST00000158125.3 Gm24901 (from geneSymbol) ENSMUST00000158125.1 ENSMUST00000158125.2 uc287hbm.1 uc287hbm.2 uc287hbm.1 uc287hbm.2 
ENSMUST00000158126.3 Gm24902 ENSMUST00000158126.3 Gm24902 (from geneSymbol) ENSMUST00000158126.1 ENSMUST00000158126.2 uc290vpt.1 uc290vpt.2 uc290vpt.1 uc290vpt.2 
ENSMUST00000158127.3 Mir1934 ENSMUST00000158127.3 microRNA 1934 (from RefSeq NR_035455.1) ENSMUST00000158127.1 ENSMUST00000158127.2 NR_035455 uc011xwz.1 uc011xwz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610464.1 [ECO:0000345] ##Evidence-Data-END## uc011xwz.1 uc011xwz.2 
ENSMUST00000158129.4 Gm24905 ENSMUST00000158129.4 Gm24905 (from geneSymbol) ENSMUST00000158129.1 ENSMUST00000158129.2 ENSMUST00000158129.3 uc289vkw.1 uc289vkw.2 uc289vkw.1 uc289vkw.2 
ENSMUST00000158131.3 Gm24903 ENSMUST00000158131.3 Gm24903 (from geneSymbol) ENSMUST00000158131.1 ENSMUST00000158131.2 uc288xxc.1 uc288xxc.2 uc288xxc.1 uc288xxc.2 
ENSMUST00000158135.3 Gm24393 ENSMUST00000158135.3 Gm24393 (from geneSymbol) ENSMUST00000158135.1 ENSMUST00000158135.2 uc292jei.1 uc292jei.2 uc292jei.1 uc292jei.2 
ENSMUST00000158136.3 Gm24392 ENSMUST00000158136.3 Gm24392 (from geneSymbol) ENSMUST00000158136.1 ENSMUST00000158136.2 uc288utf.1 uc288utf.2 uc288utf.1 uc288utf.2 
ENSMUST00000158139.3 Gm24395 ENSMUST00000158139.3 Gm24395 (from geneSymbol) ENSMUST00000158139.1 ENSMUST00000158139.2 uc290ksa.1 uc290ksa.2 uc290ksa.1 uc290ksa.2 
ENSMUST00000158141.3 Gm24394 ENSMUST00000158141.3 Gm24394 (from geneSymbol) ENSMUST00000158141.1 ENSMUST00000158141.2 uc288skw.1 uc288skw.2 uc288skw.1 uc288skw.2 
ENSMUST00000158143.3 Gm25494 ENSMUST00000158143.3 Gm25494 (from geneSymbol) ENSMUST00000158143.1 ENSMUST00000158143.2 uc287vwp.1 uc287vwp.2 uc287vwp.1 uc287vwp.2 
ENSMUST00000158145.4 Gm25066 ENSMUST00000158145.4 Gm25066 (from geneSymbol) ENSMUST00000158145.1 ENSMUST00000158145.2 ENSMUST00000158145.3 uc290wvm.1 uc290wvm.2 uc290wvm.1 uc290wvm.2 
ENSMUST00000158147.3 Gm26040 ENSMUST00000158147.3 Gm26040 (from geneSymbol) ENSMUST00000158147.1 ENSMUST00000158147.2 uc290eer.1 uc290eer.2 uc290eer.1 uc290eer.2 
ENSMUST00000158149.3 Gm26036 ENSMUST00000158149.3 Gm26036 (from geneSymbol) ENSMUST00000158149.1 ENSMUST00000158149.2 LF192504 uc290shj.1 uc290shj.2 uc290shj.1 uc290shj.2 
ENSMUST00000158151.3 Gm26038 ENSMUST00000158151.3 Gm26038 (from geneSymbol) ENSMUST00000158151.1 ENSMUST00000158151.2 uc289pfc.1 uc289pfc.2 uc289pfc.1 uc289pfc.2 
ENSMUST00000158156.3 Gm25373 ENSMUST00000158156.3 Gm25373 (from geneSymbol) ENSMUST00000158156.1 ENSMUST00000158156.2 uc291kfa.1 uc291kfa.2 uc291kfa.1 uc291kfa.2 
ENSMUST00000158157.3 Gm25375 ENSMUST00000158157.3 Gm25375 (from geneSymbol) ENSMUST00000158157.1 ENSMUST00000158157.2 uc289dza.1 uc289dza.2 uc289dza.1 uc289dza.2 
ENSMUST00000158159.3 Gm25370 ENSMUST00000158159.3 Gm25370 (from geneSymbol) ENSMUST00000158159.1 ENSMUST00000158159.2 uc291xhj.1 uc291xhj.2 uc291xhj.1 uc291xhj.2 
ENSMUST00000158166.3 Gm22542 ENSMUST00000158166.3 Gm22542 (from geneSymbol) ENSMUST00000158166.1 ENSMUST00000158166.2 uc289nkj.1 uc289nkj.2 uc289nkj.1 uc289nkj.2 
ENSMUST00000158167.3 Gm22539 ENSMUST00000158167.3 Gm22539 (from geneSymbol) ENSMUST00000158167.1 ENSMUST00000158167.2 uc292odf.1 uc292odf.2 uc292odf.1 uc292odf.2 
ENSMUST00000158168.4 Gm22540 ENSMUST00000158168.4 Gm22540 (from geneSymbol) ENSMUST00000158168.1 ENSMUST00000158168.2 ENSMUST00000158168.3 uc292gqd.1 uc292gqd.2 uc292gqd.1 uc292gqd.2 
ENSMUST00000158171.3 Gm22536 ENSMUST00000158171.3 Gm22536 (from geneSymbol) ENSMUST00000158171.1 ENSMUST00000158171.2 uc290vqy.1 uc290vqy.2 uc290vqy.1 uc290vqy.2 
ENSMUST00000158173.3 Gm22534 ENSMUST00000158173.3 Gm22534 (from geneSymbol) ENSMUST00000158173.1 ENSMUST00000158173.2 uc288bhz.1 uc288bhz.2 uc288bhz.1 uc288bhz.2 
ENSMUST00000158175.4 Gm24075 ENSMUST00000158175.4 Gm24075 (from geneSymbol) ENSMUST00000158175.1 ENSMUST00000158175.2 ENSMUST00000158175.3 uc287gst.1 uc287gst.2 uc287gst.1 uc287gst.2 
ENSMUST00000158181.4 Gm23513 ENSMUST00000158181.4 Gm23513 (from geneSymbol) ENSMUST00000158181.1 ENSMUST00000158181.2 ENSMUST00000158181.3 uc289ezy.1 uc289ezy.2 uc289ezy.1 uc289ezy.2 
ENSMUST00000158185.3 Gm22382 ENSMUST00000158185.3 Gm22382 (from geneSymbol) AK156491 ENSMUST00000158185.1 ENSMUST00000158185.2 uc292ika.1 uc292ika.2 uc292ika.1 uc292ika.2 
ENSMUST00000158186.3 Gm22381 ENSMUST00000158186.3 Gm22381 (from geneSymbol) ENSMUST00000158186.1 ENSMUST00000158186.2 uc287zzz.1 uc287zzz.2 uc287zzz.1 uc287zzz.2 
ENSMUST00000158191.3 Gm22387 ENSMUST00000158191.3 Gm22387 (from geneSymbol) ENSMUST00000158191.1 ENSMUST00000158191.2 uc288bde.1 uc288bde.2 uc288bde.1 uc288bde.2 
ENSMUST00000158192.3 Gm22386 ENSMUST00000158192.3 Gm22386 (from geneSymbol) ENSMUST00000158192.1 ENSMUST00000158192.2 uc289ndl.1 uc289ndl.2 uc289ndl.1 uc289ndl.2 
ENSMUST00000158195.3 Gm25224 ENSMUST00000158195.3 Gm25224 (from geneSymbol) ENSMUST00000158195.1 ENSMUST00000158195.2 uc288jfa.1 uc288jfa.2 uc288jfa.1 uc288jfa.2 
ENSMUST00000158198.3 Gm25226 ENSMUST00000158198.3 Gm25226 (from geneSymbol) ENSMUST00000158198.1 ENSMUST00000158198.2 uc292ory.1 uc292ory.2 uc292ory.1 uc292ory.2 
ENSMUST00000158199.3 Gm25222 ENSMUST00000158199.3 Gm25222 (from geneSymbol) ENSMUST00000158199.1 ENSMUST00000158199.2 uc290frq.1 uc290frq.2 uc290frq.1 uc290frq.2 
ENSMUST00000158204.3 Gm25227 ENSMUST00000158204.3 Gm25227 (from geneSymbol) ENSMUST00000158204.1 ENSMUST00000158204.2 uc287gpr.1 uc287gpr.2 uc287gpr.1 uc287gpr.2 
ENSMUST00000158205.4 Gm23545 ENSMUST00000158205.4 Gm23545 (from geneSymbol) ENSMUST00000158205.1 ENSMUST00000158205.2 ENSMUST00000158205.3 uc288yag.1 uc288yag.2 uc288yag.1 uc288yag.2 
ENSMUST00000158210.3 Gm23547 ENSMUST00000158210.3 Gm23547 (from geneSymbol) ENSMUST00000158210.1 ENSMUST00000158210.2 uc291ity.1 uc291ity.2 uc291ity.1 uc291ity.2 
ENSMUST00000158211.3 Gm23546 ENSMUST00000158211.3 Gm23546 (from geneSymbol) ENSMUST00000158211.1 ENSMUST00000158211.2 uc289vhj.1 uc289vhj.2 uc289vhj.1 uc289vhj.2 
ENSMUST00000158214.4 Gm27510 ENSMUST00000158214.4 Gm27510 (from geneSymbol) ENSMUST00000158214.1 ENSMUST00000158214.2 ENSMUST00000158214.3 uc292pqt.1 uc292pqt.2 uc292pqt.1 uc292pqt.2 
ENSMUST00000158215.3 Gm26358 ENSMUST00000158215.3 Gm26358 (from geneSymbol) ENSMUST00000158215.1 ENSMUST00000158215.2 uc290izd.1 uc290izd.2 uc290izd.1 uc290izd.2 
ENSMUST00000158218.4 Gm26357 ENSMUST00000158218.4 Gm26357 (from geneSymbol) ENSMUST00000158218.1 ENSMUST00000158218.2 ENSMUST00000158218.3 uc287twl.1 uc287twl.2 uc287twl.1 uc287twl.2 
ENSMUST00000158221.3 Gm26354 ENSMUST00000158221.3 Gm26354 (from geneSymbol) ENSMUST00000158221.1 ENSMUST00000158221.2 uc290ecx.1 uc290ecx.2 uc290ecx.1 uc290ecx.2 
ENSMUST00000158223.3 Gm26352 ENSMUST00000158223.3 Gm26352 (from geneSymbol) ENSMUST00000158223.1 ENSMUST00000158223.2 uc287hsw.1 uc287hsw.2 uc287hsw.1 uc287hsw.2 
ENSMUST00000158225.3 Gm24729 ENSMUST00000158225.3 Gm24729 (from geneSymbol) ENSMUST00000158225.1 ENSMUST00000158225.2 uc287iwg.1 uc287iwg.2 uc287iwg.1 uc287iwg.2 
ENSMUST00000158226.3 Gm24728 ENSMUST00000158226.3 Gm24728 (from geneSymbol) ENSMUST00000158226.1 ENSMUST00000158226.2 uc290kgj.1 uc290kgj.2 uc290kgj.1 uc290kgj.2 
ENSMUST00000158227.3 Gm24731 ENSMUST00000158227.3 Gm24731 (from geneSymbol) ENSMUST00000158227.1 ENSMUST00000158227.2 uc288geo.1 uc288geo.2 uc288geo.1 uc288geo.2 
ENSMUST00000158228.3 Gm24730 ENSMUST00000158228.3 Gm24730 (from geneSymbol) ENSMUST00000158228.1 ENSMUST00000158228.2 uc289mhr.1 uc289mhr.2 uc289mhr.1 uc289mhr.2 
ENSMUST00000158229.4 Gm24725 ENSMUST00000158229.4 Gm24725 (from geneSymbol) ENSMUST00000158229.1 ENSMUST00000158229.2 ENSMUST00000158229.3 uc288bpx.1 uc288bpx.2 uc288bpx.1 uc288bpx.2 
ENSMUST00000158232.3 Gm24726 ENSMUST00000158232.3 Gm24726 (from geneSymbol) ENSMUST00000158232.1 ENSMUST00000158232.2 uc287pkl.1 uc287pkl.2 uc287pkl.1 uc287pkl.2 
ENSMUST00000158233.3 Gm24723 ENSMUST00000158233.3 Gm24723 (from geneSymbol) ENSMUST00000158233.1 ENSMUST00000158233.2 uc287gtx.1 uc287gtx.2 uc287gtx.1 uc287gtx.2 
ENSMUST00000158235.3 Mir1947 ENSMUST00000158235.3 microRNA 1947 (from RefSeq NR_035469.1) ENSMUST00000158235.1 ENSMUST00000158235.2 NR_035469 uc012aev.1 uc012aev.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610471.1 [ECO:0000345] ##Evidence-Data-END## uc012aev.1 uc012aev.2 
ENSMUST00000158237.4 Gm24316 ENSMUST00000158237.4 Gm24316 (from geneSymbol) DQ558729 ENSMUST00000158237.1 ENSMUST00000158237.2 ENSMUST00000158237.3 uc289due.1 uc289due.2 uc289due.1 uc289due.2 
ENSMUST00000158238.3 Gm23067 ENSMUST00000158238.3 Gm23067 (from geneSymbol) ENSMUST00000158238.1 ENSMUST00000158238.2 uc290wem.1 uc290wem.2 uc290wem.1 uc290wem.2 
ENSMUST00000158243.3 Gm23072 ENSMUST00000158243.3 Gm23072 (from geneSymbol) ENSMUST00000158243.1 ENSMUST00000158243.2 uc289vyw.1 uc289vyw.2 uc289vyw.1 uc289vyw.2 
ENSMUST00000158245.3 Gm25866 ENSMUST00000158245.3 Gm25866 (from geneSymbol) ENSMUST00000158245.1 ENSMUST00000158245.2 uc290bdx.1 uc290bdx.2 uc290bdx.1 uc290bdx.2 
ENSMUST00000158249.3 Gm25863 ENSMUST00000158249.3 Gm25863 (from geneSymbol) ENSMUST00000158249.1 ENSMUST00000158249.2 uc290dyo.1 uc290dyo.2 uc290dyo.1 uc290dyo.2 
ENSMUST00000158250.3 Gm25862 ENSMUST00000158250.3 Gm25862 (from geneSymbol) ENSMUST00000158250.1 ENSMUST00000158250.2 uc287rrx.1 uc287rrx.2 uc287rrx.1 uc287rrx.2 
ENSMUST00000158251.4 Gm25861 ENSMUST00000158251.4 Gm25861 (from geneSymbol) ENSMUST00000158251.1 ENSMUST00000158251.2 ENSMUST00000158251.3 uc292fhw.1 uc292fhw.2 uc292fhw.1 uc292fhw.2 
ENSMUST00000158252.3 Gm25860 ENSMUST00000158252.3 Gm25860 (from geneSymbol) ENSMUST00000158252.1 ENSMUST00000158252.2 uc291ssg.1 uc291ssg.2 uc291ssg.1 uc291ssg.2 
ENSMUST00000158253.3 Gm22233 ENSMUST00000158253.3 Gm22233 (from geneSymbol) ENSMUST00000158253.1 ENSMUST00000158253.2 uc292qoi.1 uc292qoi.2 uc292qoi.1 uc292qoi.2 
ENSMUST00000158254.3 Gm25867 ENSMUST00000158254.3 Gm25867 (from geneSymbol) ENSMUST00000158254.1 ENSMUST00000158254.2 uc288aqx.1 uc288aqx.2 uc288aqx.1 uc288aqx.2 
ENSMUST00000158258.3 Gm24212 ENSMUST00000158258.3 Gm24212 (from geneSymbol) ENSMUST00000158258.1 ENSMUST00000158258.2 uc292bxq.1 uc292bxq.2 uc292bxq.1 uc292bxq.2 
ENSMUST00000158259.3 Gm24216 ENSMUST00000158259.3 Gm24216 (from geneSymbol) ENSMUST00000158259.1 ENSMUST00000158259.2 uc290hzm.1 uc290hzm.2 uc290hzm.1 uc290hzm.2 
ENSMUST00000158263.3 Gm24210 ENSMUST00000158263.3 Gm24210 (from geneSymbol) ENSMUST00000158263.1 ENSMUST00000158263.2 uc291tnt.1 uc291tnt.2 uc291tnt.1 uc291tnt.2 
ENSMUST00000158264.3 Gm24211 ENSMUST00000158264.3 Gm24211 (from geneSymbol) ENSMUST00000158264.1 ENSMUST00000158264.2 uc288acp.1 uc288acp.2 uc288acp.1 uc288acp.2 
ENSMUST00000158266.4 Gm22516 ENSMUST00000158266.4 Gm22516 (from geneSymbol) ENSMUST00000158266.1 ENSMUST00000158266.2 ENSMUST00000158266.3 uc289uwt.1 uc289uwt.2 uc289uwt.1 uc289uwt.2 
ENSMUST00000158269.3 Gm22520 ENSMUST00000158269.3 Gm22520 (from geneSymbol) ENSMUST00000158269.1 ENSMUST00000158269.2 uc289som.1 uc289som.2 uc289som.1 uc289som.2 
ENSMUST00000158270.3 Gm22519 ENSMUST00000158270.3 Gm22519 (from geneSymbol) ENSMUST00000158270.1 ENSMUST00000158270.2 uc288ynz.1 uc288ynz.2 uc288ynz.1 uc288ynz.2 
ENSMUST00000158271.3 Gm22522 ENSMUST00000158271.3 Gm22522 (from geneSymbol) ENSMUST00000158271.1 ENSMUST00000158271.2 uc292rls.1 uc292rls.2 uc292rls.1 uc292rls.2 
ENSMUST00000158272.3 Gm22521 ENSMUST00000158272.3 Gm22521 (from geneSymbol) ENSMUST00000158272.1 ENSMUST00000158272.2 uc288yhr.1 uc288yhr.2 uc288yhr.1 uc288yhr.2 
ENSMUST00000158274.4 Gm24314 ENSMUST00000158274.4 Gm24314 (from geneSymbol) ENSMUST00000158274.1 ENSMUST00000158274.2 ENSMUST00000158274.3 uc290wvo.1 uc290wvo.2 uc290wvo.1 uc290wvo.2 
ENSMUST00000158275.3 Gm25436 ENSMUST00000158275.3 Gm25436 (from geneSymbol) ENSMUST00000158275.1 ENSMUST00000158275.2 uc291fhs.1 uc291fhs.2 uc291fhs.1 uc291fhs.2 
ENSMUST00000158276.3 Mir1943 ENSMUST00000158276.3 microRNA 1943 (from RefSeq NR_035464.1) ENSMUST00000158276.1 ENSMUST00000158276.2 NR_035464 uc011zwa.1 uc011zwa.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610468.1 [ECO:0000345] ##Evidence-Data-END## uc011zwa.1 uc011zwa.2 
ENSMUST00000158278.3 Gm25434 ENSMUST00000158278.3 Gm25434 (from geneSymbol) ENSMUST00000158278.1 ENSMUST00000158278.2 uc291jxg.1 uc291jxg.2 uc291jxg.1 uc291jxg.2 
ENSMUST00000158280.3 Gm25439 ENSMUST00000158280.3 Gm25439 (from geneSymbol) ENSMUST00000158280.1 ENSMUST00000158280.2 uc292fos.1 uc292fos.2 uc292fos.1 uc292fos.2 
ENSMUST00000158281.3 Gm25438 ENSMUST00000158281.3 Gm25438 (from geneSymbol) ENSMUST00000158281.1 ENSMUST00000158281.2 uc288fyu.1 uc288fyu.2 uc288fyu.1 uc288fyu.2 
ENSMUST00000158282.3 Gm25437 ENSMUST00000158282.3 Gm25437 (from geneSymbol) ENSMUST00000158282.1 ENSMUST00000158282.2 uc289rjl.1 uc289rjl.2 uc289rjl.1 uc289rjl.2 
ENSMUST00000158286.3 Gm22609 ENSMUST00000158286.3 Gm22609 (from geneSymbol) ENSMUST00000158286.1 ENSMUST00000158286.2 uc287lso.1 uc287lso.2 uc287lso.1 uc287lso.2 
ENSMUST00000158289.3 Gm22605 ENSMUST00000158289.3 Gm22605 (from geneSymbol) ENSMUST00000158289.1 ENSMUST00000158289.2 uc290ntt.1 uc290ntt.2 uc290ntt.1 uc290ntt.2 
ENSMUST00000158290.3 Gm22606 ENSMUST00000158290.3 Gm22606 (from geneSymbol) ENSMUST00000158290.1 ENSMUST00000158290.2 uc289xgy.1 uc289xgy.2 uc289xgy.1 uc289xgy.2 
ENSMUST00000158292.3 Gm22833 ENSMUST00000158292.3 Gm22833 (from geneSymbol) ENSMUST00000158292.1 ENSMUST00000158292.2 uc291irc.1 uc291irc.2 uc291irc.1 uc291irc.2 
ENSMUST00000158297.3 Gm24296 ENSMUST00000158297.3 Gm24296 (from geneSymbol) ENSMUST00000158297.1 ENSMUST00000158297.2 uc288gke.1 uc288gke.2 uc288gke.1 uc288gke.2 
ENSMUST00000158298.3 Gm24295 ENSMUST00000158298.3 Gm24295 (from geneSymbol) ENSMUST00000158298.1 ENSMUST00000158298.2 uc288owh.1 uc288owh.2 uc288owh.1 uc288owh.2 
ENSMUST00000158299.4 Gm24298 ENSMUST00000158299.4 Gm24298 (from geneSymbol) ENSMUST00000158299.1 ENSMUST00000158299.2 ENSMUST00000158299.3 uc287vff.1 uc287vff.2 uc287vff.1 uc287vff.2 
ENSMUST00000158303.3 Gm25898 ENSMUST00000158303.3 Gm25898 (from geneSymbol) ENSMUST00000158303.1 ENSMUST00000158303.2 uc289wdv.1 uc289wdv.2 uc289wdv.1 uc289wdv.2 
ENSMUST00000158304.3 Gm24299 ENSMUST00000158304.3 Gm24299 (from geneSymbol) ENSMUST00000158304.1 ENSMUST00000158304.2 uc292epr.1 uc292epr.2 uc292epr.1 uc292epr.2 
ENSMUST00000158305.3 Gm25921 ENSMUST00000158305.3 Gm25921 (from geneSymbol) ENSMUST00000158305.1 ENSMUST00000158305.2 uc289iil.1 uc289iil.2 uc289iil.1 uc289iil.2 
ENSMUST00000158310.3 Gm25924 ENSMUST00000158310.3 Gm25924 (from geneSymbol) ENSMUST00000158310.1 ENSMUST00000158310.2 uc291vbu.1 uc291vbu.2 uc291vbu.1 uc291vbu.2 
ENSMUST00000158316.3 Gm22517 ENSMUST00000158316.3 Gm22517 (from geneSymbol) ENSMUST00000158316.1 ENSMUST00000158316.2 uc290bhp.1 uc290bhp.2 uc290bhp.1 uc290bhp.2 
ENSMUST00000158317.4 Gm23260 ENSMUST00000158317.4 Gm23260 (from geneSymbol) ENSMUST00000158317.1 ENSMUST00000158317.2 ENSMUST00000158317.3 uc292bdz.1 uc292bdz.2 uc292bdz.1 uc292bdz.2 
ENSMUST00000158319.3 Gm23258 ENSMUST00000158319.3 Gm23258 (from geneSymbol) ENSMUST00000158319.1 ENSMUST00000158319.2 uc292ogl.1 uc292ogl.2 uc292ogl.1 uc292ogl.2 
ENSMUST00000158323.3 Gm23262 ENSMUST00000158323.3 Gm23262 (from geneSymbol) AF357463 ENSMUST00000158323.1 ENSMUST00000158323.2 uc291umw.1 uc291umw.2 uc291umw.1 uc291umw.2 
ENSMUST00000158326.4 Gm24940 ENSMUST00000158326.4 Gm24940 (from geneSymbol) ENSMUST00000158326.1 ENSMUST00000158326.2 ENSMUST00000158326.3 uc287nhh.1 uc287nhh.2 uc287nhh.1 uc287nhh.2 
ENSMUST00000158328.3 Gm24942 ENSMUST00000158328.3 Gm24942 (from geneSymbol) ENSMUST00000158328.1 ENSMUST00000158328.2 uc287iqy.1 uc287iqy.2 uc287iqy.1 uc287iqy.2 
ENSMUST00000158329.4 Gm24943 ENSMUST00000158329.4 Gm24943 (from geneSymbol) ENSMUST00000158329.1 ENSMUST00000158329.2 ENSMUST00000158329.3 uc290msa.1 uc290msa.2 uc290msa.1 uc290msa.2 
ENSMUST00000158333.3 Scarna8 ENSMUST00000158333.3 small Cajal body-specific RNA 8 (from RefSeq NR_028545.1) ENSMUST00000158333.1 ENSMUST00000158333.2 NR_028545 uc012dgr.1 uc012dgr.2 uc012dgr.3 uc012dgr.1 uc012dgr.2 uc012dgr.3 
ENSMUST00000158334.3 Gm24947 ENSMUST00000158334.3 Gm24947 (from geneSymbol) ENSMUST00000158334.1 ENSMUST00000158334.2 uc291jbx.1 uc291jbx.2 uc291jbx.1 uc291jbx.2 
ENSMUST00000158335.3 Gm22090 ENSMUST00000158335.3 Gm22090 (from geneSymbol) ENSMUST00000158335.1 ENSMUST00000158335.2 uc292pyk.1 uc292pyk.2 uc292pyk.1 uc292pyk.2 
ENSMUST00000158336.3 Gm22089 ENSMUST00000158336.3 Gm22089 (from geneSymbol) ENSMUST00000158336.1 ENSMUST00000158336.2 LF204775 uc287kqs.1 uc287kqs.2 uc287kqs.1 uc287kqs.2 
ENSMUST00000158339.4 Gm22087 ENSMUST00000158339.4 Gm22087 (from geneSymbol) ENSMUST00000158339.1 ENSMUST00000158339.2 ENSMUST00000158339.3 uc287qxw.1 uc287qxw.2 uc287qxw.1 uc287qxw.2 
ENSMUST00000158343.4 Gm24805 ENSMUST00000158343.4 Gm24805 (from geneSymbol) ENSMUST00000158343.1 ENSMUST00000158343.2 ENSMUST00000158343.3 uc289qpl.1 uc289qpl.2 uc289qpl.1 uc289qpl.2 
ENSMUST00000158344.3 Gm22085 ENSMUST00000158344.3 Gm22085 (from geneSymbol) ENSMUST00000158344.1 ENSMUST00000158344.2 uc292dad.1 uc292dad.2 uc292dad.1 uc292dad.2 
ENSMUST00000158345.3 Rnu7-ps3 ENSMUST00000158345.3 Rnu7-ps3 (from geneSymbol) ENSMUST00000158345.1 ENSMUST00000158345.2 uc287mdk.1 uc287mdk.2 uc287mdk.1 uc287mdk.2 
ENSMUST00000158349.3 Gm25619 ENSMUST00000158349.3 Gm25619 (from geneSymbol) ENSMUST00000158349.1 ENSMUST00000158349.2 uc287mgm.1 uc287mgm.2 uc287mgm.1 uc287mgm.2 
ENSMUST00000158350.3 Gm23760 ENSMUST00000158350.3 Gm23760 (from geneSymbol) ENSMUST00000158350.1 ENSMUST00000158350.2 uc291cpj.1 uc291cpj.2 uc291cpj.1 uc291cpj.2 
ENSMUST00000158354.3 Gm23758 ENSMUST00000158354.3 Gm23758 (from geneSymbol) ENSMUST00000158354.1 ENSMUST00000158354.2 uc288tun.1 uc288tun.2 uc288tun.1 uc288tun.2 
ENSMUST00000158355.3 Mir669m-2 ENSMUST00000158355.3 microRNA 669m-2 (from RefSeq NR_035475.1) ENSMUST00000158355.1 ENSMUST00000158355.2 NR_035475 uc056zku.1 uc056zku.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zku.1 uc056zku.2 
ENSMUST00000158357.3 Gm25600 ENSMUST00000158357.3 Gm25600 (from geneSymbol) ENSMUST00000158357.1 ENSMUST00000158357.2 uc290pyp.1 uc290pyp.2 uc290pyp.1 uc290pyp.2 
ENSMUST00000158358.3 Mir1952 ENSMUST00000158358.3 microRNA 1952 (from RefSeq NR_035477.1) ENSMUST00000158358.1 ENSMUST00000158358.2 NR_035477 uc012cex.1 uc012cex.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012cex.1 uc012cex.2 
ENSMUST00000158359.3 Gm25604 ENSMUST00000158359.3 Gm25604 (from geneSymbol) ENSMUST00000158359.1 ENSMUST00000158359.2 uc290pxo.1 uc290pxo.2 uc290pxo.1 uc290pxo.2 
ENSMUST00000158360.3 Mir1946a ENSMUST00000158360.3 microRNA 1946a (from RefSeq NR_035468.1) ENSMUST00000158360.1 ENSMUST00000158360.2 NR_035468 uc012aek.1 uc012aek.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012aek.1 uc012aek.2 
ENSMUST00000158362.3 Gm25602 ENSMUST00000158362.3 Gm25602 (from geneSymbol) ENSMUST00000158362.1 ENSMUST00000158362.2 uc287rhe.1 uc287rhe.2 uc287rhe.1 uc287rhe.2 
ENSMUST00000158365.3 Gm22767 ENSMUST00000158365.3 Gm22767 (from geneSymbol) ENSMUST00000158365.1 ENSMUST00000158365.2 uc290qnd.1 uc290qnd.2 uc290qnd.1 uc290qnd.2 
ENSMUST00000158367.4 Gm22769 ENSMUST00000158367.4 Gm22769 (from geneSymbol) ENSMUST00000158367.1 ENSMUST00000158367.2 ENSMUST00000158367.3 uc289fir.1 uc289fir.2 uc289fir.1 uc289fir.2 
ENSMUST00000158370.3 Gm22764 ENSMUST00000158370.3 Gm22764 (from geneSymbol) ENSMUST00000158370.1 ENSMUST00000158370.2 uc288wkj.1 uc288wkj.2 uc288wkj.1 uc288wkj.2 
ENSMUST00000158372.4 Gm22766 ENSMUST00000158372.4 Gm22766 (from geneSymbol) ENSMUST00000158372.1 ENSMUST00000158372.2 ENSMUST00000158372.3 uc288fjh.1 uc288fjh.2 uc288fjh.1 uc288fjh.2 
ENSMUST00000158374.3 Gm22763 ENSMUST00000158374.3 Gm22763 (from geneSymbol) ENSMUST00000158374.1 ENSMUST00000158374.2 uc291irw.1 uc291irw.2 uc291irw.1 uc291irw.2 
ENSMUST00000158376.3 Gm23852 ENSMUST00000158376.3 Gm23852 (from geneSymbol) ENSMUST00000158376.1 ENSMUST00000158376.2 uc289fhs.1 uc289fhs.2 uc289fhs.1 uc289fhs.2 
ENSMUST00000158377.3 Gm23855 ENSMUST00000158377.3 Gm23855 (from geneSymbol) ENSMUST00000158377.1 ENSMUST00000158377.2 uc288npl.1 uc288npl.2 uc288npl.1 uc288npl.2 
ENSMUST00000158380.4 Gm23856 ENSMUST00000158380.4 Gm23856 (from geneSymbol) ENSMUST00000158380.1 ENSMUST00000158380.2 ENSMUST00000158380.3 uc292kza.1 uc292kza.2 uc292kza.1 uc292kza.2 
ENSMUST00000158382.3 Gm23877 ENSMUST00000158382.3 Gm23877 (from geneSymbol) ENSMUST00000158382.1 ENSMUST00000158382.2 uc289szl.1 uc289szl.2 uc289szl.1 uc289szl.2 
ENSMUST00000158383.3 Gm23859 ENSMUST00000158383.3 Gm23859 (from geneSymbol) ENSMUST00000158383.1 ENSMUST00000158383.2 uc289pwr.1 uc289pwr.2 uc289pwr.1 uc289pwr.2 
ENSMUST00000158384.3 Gm23858 ENSMUST00000158384.3 Gm23858 (from geneSymbol) ENSMUST00000158384.1 ENSMUST00000158384.2 uc289zvo.1 uc289zvo.2 uc289zvo.1 uc289zvo.2 
ENSMUST00000158386.4 Gm24879 ENSMUST00000158386.4 Gm24879 (from geneSymbol) ENSMUST00000158386.1 ENSMUST00000158386.2 ENSMUST00000158386.3 uc289eap.1 uc289eap.2 uc289eap.1 uc289eap.2 
ENSMUST00000158389.3 Gm25520 ENSMUST00000158389.3 Gm25520 (from geneSymbol) ENSMUST00000158389.1 ENSMUST00000158389.2 LF202079 uc292pbt.1 uc292pbt.2 uc292pbt.1 uc292pbt.2 
ENSMUST00000158392.3 Gm25519 ENSMUST00000158392.3 Gm25519 (from geneSymbol) ENSMUST00000158392.1 ENSMUST00000158392.2 uc290iwj.1 uc290iwj.2 uc290iwj.1 uc290iwj.2 
ENSMUST00000158393.3 Gm25521 ENSMUST00000158393.3 Gm25521 (from geneSymbol) ENSMUST00000158393.1 ENSMUST00000158393.2 uc290xdn.1 uc290xdn.2 uc290xdn.1 uc290xdn.2 
ENSMUST00000158394.3 Gm25522 ENSMUST00000158394.3 Gm25522 (from geneSymbol) ENSMUST00000158394.1 ENSMUST00000158394.2 uc287uqr.1 uc287uqr.2 uc287uqr.1 uc287uqr.2 
ENSMUST00000158399.3 Gm25016 ENSMUST00000158399.3 Gm25016 (from geneSymbol) ENSMUST00000158399.1 ENSMUST00000158399.2 uc287qcy.1 uc287qcy.2 uc287qcy.1 uc287qcy.2 
ENSMUST00000158400.3 Gm25015 ENSMUST00000158400.3 Gm25015 (from geneSymbol) ENSMUST00000158400.1 ENSMUST00000158400.2 uc288gge.1 uc288gge.2 uc288gge.1 uc288gge.2 
ENSMUST00000158401.5 Gm25014 ENSMUST00000158401.5 Gm25014 (from geneSymbol) ENSMUST00000158401.1 ENSMUST00000158401.2 ENSMUST00000158401.3 ENSMUST00000158401.4 uc291yiw.1 uc291yiw.2 uc291yiw.1 uc291yiw.2 
ENSMUST00000158402.3 Gm25013 ENSMUST00000158402.3 Gm25013 (from geneSymbol) ENSMUST00000158402.1 ENSMUST00000158402.2 uc290jde.1 uc290jde.2 uc290jde.1 uc290jde.2 
ENSMUST00000158403.4 Gm25010 ENSMUST00000158403.4 Gm25010 (from geneSymbol) ENSMUST00000158403.1 ENSMUST00000158403.2 ENSMUST00000158403.3 uc290mdk.1 uc290mdk.2 uc290mdk.1 uc290mdk.2 
ENSMUST00000158404.3 Gm25009 ENSMUST00000158404.3 Gm25009 (from geneSymbol) ENSMUST00000158404.1 ENSMUST00000158404.2 uc290iga.1 uc290iga.2 uc290iga.1 uc290iga.2 
ENSMUST00000158408.3 Gm22163 ENSMUST00000158408.3 Gm22163 (from geneSymbol) ENSMUST00000158408.1 ENSMUST00000158408.2 uc289fml.1 uc289fml.2 uc289fml.1 uc289fml.2 
ENSMUST00000158409.3 Gm22156 ENSMUST00000158409.3 Gm22156 (from geneSymbol) ENSMUST00000158409.1 ENSMUST00000158409.2 uc287wrs.1 uc287wrs.2 uc287wrs.1 uc287wrs.2 
ENSMUST00000158410.3 Gm22157 ENSMUST00000158410.3 Gm22157 (from geneSymbol) ENSMUST00000158410.1 ENSMUST00000158410.2 uc288miq.1 uc288miq.2 uc288miq.1 uc288miq.2 
ENSMUST00000158411.3 Gm22158 ENSMUST00000158411.3 Gm22158 (from geneSymbol) ENSMUST00000158411.1 ENSMUST00000158411.2 uc289dhe.1 uc289dhe.2 uc289dhe.1 uc289dhe.2 
ENSMUST00000158412.3 Gm22159 ENSMUST00000158412.3 Gm22159 (from geneSymbol) ENSMUST00000158412.1 ENSMUST00000158412.2 uc287kyw.1 uc287kyw.2 uc287kyw.1 uc287kyw.2 
ENSMUST00000158414.4 Gm22165 ENSMUST00000158414.4 Gm22165 (from geneSymbol) ENSMUST00000158414.1 ENSMUST00000158414.2 ENSMUST00000158414.3 uc290fqk.1 uc290fqk.2 uc290fqk.1 uc290fqk.2 
ENSMUST00000158415.4 Gm26174 ENSMUST00000158415.4 Gm26174 (from geneSymbol) ENSMUST00000158415.1 ENSMUST00000158415.2 ENSMUST00000158415.3 uc292pge.1 uc292pge.2 uc292pge.1 uc292pge.2 
ENSMUST00000158420.3 Gm26169 ENSMUST00000158420.3 Gm26169 (from geneSymbol) ENSMUST00000158420.1 ENSMUST00000158420.2 uc287oug.1 uc287oug.2 uc287oug.1 uc287oug.2 
ENSMUST00000158421.4 Gm26172 ENSMUST00000158421.4 Gm26172 (from geneSymbol) ENSMUST00000158421.1 ENSMUST00000158421.2 ENSMUST00000158421.3 uc288lbd.1 uc288lbd.2 uc288lbd.1 uc288lbd.2 
ENSMUST00000158426.3 Gm23354 ENSMUST00000158426.3 Gm23354 (from geneSymbol) ENSMUST00000158426.1 ENSMUST00000158426.2 uc290ome.1 uc290ome.2 uc290ome.1 uc290ome.2 
ENSMUST00000158427.4 Gm23351 ENSMUST00000158427.4 Gm23351 (from geneSymbol) ENSMUST00000158427.1 ENSMUST00000158427.2 ENSMUST00000158427.3 uc288ltm.1 uc288ltm.2 uc288ltm.1 uc288ltm.2 
ENSMUST00000158428.3 Gm23352 ENSMUST00000158428.3 Gm23352 (from geneSymbol) ENSMUST00000158428.1 ENSMUST00000158428.2 uc289heq.1 uc289heq.2 uc289heq.1 uc289heq.2 
ENSMUST00000158429.2 Gm23350 ENSMUST00000158429.2 Gm23350 (from geneSymbol) ENSMUST00000158429.1 uc289nwm.1 uc289nwm.2 uc289nwm.1 uc289nwm.2 
ENSMUST00000158430.3 Gm22675 ENSMUST00000158430.3 Gm22675 (from geneSymbol) ENSMUST00000158430.1 ENSMUST00000158430.2 uc289ukt.1 uc289ukt.2 uc289ukt.1 uc289ukt.2 
ENSMUST00000158431.4 Gm23016 ENSMUST00000158431.4 Gm23016 (from geneSymbol) ENSMUST00000158431.1 ENSMUST00000158431.2 ENSMUST00000158431.3 uc289pja.1 uc289pja.2 uc289pja.1 uc289pja.2 
ENSMUST00000158432.4 Gm23349 ENSMUST00000158432.4 Gm23349 (from geneSymbol) ENSMUST00000158432.1 ENSMUST00000158432.2 ENSMUST00000158432.3 uc287osc.1 uc287osc.2 uc287osc.1 uc287osc.2 
ENSMUST00000158435.4 Gm22361 ENSMUST00000158435.4 Gm22361 (from geneSymbol) ENSMUST00000158435.1 ENSMUST00000158435.2 ENSMUST00000158435.3 uc290izc.1 uc290izc.2 uc290izc.1 uc290izc.2 
ENSMUST00000158441.3 Gm22836 ENSMUST00000158441.3 Gm22836 (from geneSymbol) ENSMUST00000158441.1 ENSMUST00000158441.2 uc292jeh.1 uc292jeh.2 uc292jeh.1 uc292jeh.2 
ENSMUST00000158443.3 Gm22841 ENSMUST00000158443.3 Gm22841 (from geneSymbol) ENSMUST00000158443.1 ENSMUST00000158443.2 uc291zxa.1 uc291zxa.2 uc291zxa.1 uc291zxa.2 
ENSMUST00000158444.3 Gm22840 ENSMUST00000158444.3 Gm22840 (from geneSymbol) ENSMUST00000158444.1 ENSMUST00000158444.2 uc291hgj.1 uc291hgj.2 uc291hgj.1 uc291hgj.2 
ENSMUST00000158446.3 Gm24499 ENSMUST00000158446.3 Gm24499 (from geneSymbol) ENSMUST00000158446.1 ENSMUST00000158446.2 uc288gvw.1 uc288gvw.2 uc288gvw.1 uc288gvw.2 
ENSMUST00000158449.3 Gm23817 ENSMUST00000158449.3 Gm23817 (from geneSymbol) ENSMUST00000158449.1 ENSMUST00000158449.2 uc288hmz.1 uc288hmz.2 uc288hmz.1 uc288hmz.2 
ENSMUST00000158452.4 Gm54782 ENSMUST00000158452.4 Gm54782 (from geneSymbol) ENSMUST00000158452.1 ENSMUST00000158452.2 ENSMUST00000158452.3 uc290ghg.1 uc290ghg.2 uc290ghg.1 uc290ghg.2 
ENSMUST00000158453.3 Gm24502 ENSMUST00000158453.3 Gm24502 (from geneSymbol) ENSMUST00000158453.1 ENSMUST00000158453.2 uc290wlv.1 uc290wlv.2 uc290wlv.1 uc290wlv.2 
ENSMUST00000158454.3 Gm24503 ENSMUST00000158454.3 Gm24503 (from geneSymbol) ENSMUST00000158454.1 ENSMUST00000158454.2 uc290fbn.1 uc290fbn.2 uc290fbn.1 uc290fbn.2 
ENSMUST00000158455.3 Gm24003 ENSMUST00000158455.3 Gm24003 (from geneSymbol) ENSMUST00000158455.1 ENSMUST00000158455.2 uc290ulv.1 uc290ulv.2 uc290ulv.1 uc290ulv.2 
ENSMUST00000158456.3 Gm24002 ENSMUST00000158456.3 Gm24002 (from geneSymbol) ENSMUST00000158456.1 ENSMUST00000158456.2 uc290ruy.1 uc290ruy.2 uc290ruy.1 uc290ruy.2 
ENSMUST00000158458.3 Rnu7 ENSMUST00000158458.3 U7 small nuclear RNA (from RefSeq NR_024201.3) ENSMUST00000158458.1 ENSMUST00000158458.2 NR_024201 uc057lro.1 uc057lro.2 uc057lro.1 uc057lro.2 
ENSMUST00000158460.3 Gm24004 ENSMUST00000158460.3 Gm24004 (from geneSymbol) ENSMUST00000158460.1 ENSMUST00000158460.2 LF204938 uc292jte.1 uc292jte.2 uc292jte.1 uc292jte.2 
ENSMUST00000158462.3 Gm24006 ENSMUST00000158462.3 Gm24006 (from geneSymbol) ENSMUST00000158462.1 ENSMUST00000158462.2 uc289rsy.1 uc289rsy.2 uc289rsy.1 uc289rsy.2 
ENSMUST00000158466.3 Gm25656 ENSMUST00000158466.3 Gm25656 (from geneSymbol) ENSMUST00000158466.1 ENSMUST00000158466.2 uc291hnm.1 uc291hnm.2 uc291hnm.1 uc291hnm.2 
ENSMUST00000158468.5 Snord11 ENSMUST00000158468.5 small nucleolar RNA, C/D box 11 (from RefSeq NR_028521.1) ENSMUST00000158468.1 ENSMUST00000158468.2 ENSMUST00000158468.3 ENSMUST00000158468.4 NR_028521 uc011wls.1 uc011wls.2 uc011wls.3 uc011wls.1 uc011wls.2 uc011wls.3 
ENSMUST00000158471.3 Gm25657 ENSMUST00000158471.3 Gm25657 (from geneSymbol) ENSMUST00000158471.1 ENSMUST00000158471.2 uc287trf.1 uc287trf.2 uc287trf.1 uc287trf.2 
ENSMUST00000158472.3 Gm25658 ENSMUST00000158472.3 Gm25658 (from geneSymbol) ENSMUST00000158472.1 ENSMUST00000158472.2 uc287ukc.1 uc287ukc.2 uc287ukc.1 uc287ukc.2 
ENSMUST00000158473.3 Gm25653 ENSMUST00000158473.3 Gm25653 (from geneSymbol) ENSMUST00000158473.1 ENSMUST00000158473.2 uc290nhh.1 uc290nhh.2 uc290nhh.1 uc290nhh.2 
ENSMUST00000158477.3 Gm23113 ENSMUST00000158477.3 Gm23113 (from geneSymbol) ENSMUST00000158477.1 ENSMUST00000158477.2 uc289sah.1 uc289sah.2 uc289sah.1 uc289sah.2 
ENSMUST00000158481.3 Gm23116 ENSMUST00000158481.3 Gm23116 (from geneSymbol) ENSMUST00000158481.1 ENSMUST00000158481.2 LF200607 uc289cqc.1 uc289cqc.2 uc289cqc.1 uc289cqc.2 
ENSMUST00000158482.3 Gm23117 ENSMUST00000158482.3 Gm23117 (from geneSymbol) ENSMUST00000158482.1 ENSMUST00000158482.2 uc288mlg.1 uc288mlg.2 uc288mlg.1 uc288mlg.2 
ENSMUST00000158484.4 Gm23916 ENSMUST00000158484.4 Gm23916 (from geneSymbol) ENSMUST00000158484.1 ENSMUST00000158484.2 ENSMUST00000158484.3 uc289egb.1 uc289egb.2 uc289egb.1 uc289egb.2 
ENSMUST00000158488.3 Gm22902 ENSMUST00000158488.3 Gm22902 (from geneSymbol) DQ311506 ENSMUST00000158488.1 ENSMUST00000158488.2 uc290aqm.1 uc290aqm.2 uc290aqm.1 uc290aqm.2 
ENSMUST00000158489.3 Gm25906 ENSMUST00000158489.3 Gm25906 (from geneSymbol) ENSMUST00000158489.1 ENSMUST00000158489.2 uc292amg.1 uc292amg.2 uc292amg.1 uc292amg.2 
ENSMUST00000158491.3 Gm25904 ENSMUST00000158491.3 Gm25904 (from geneSymbol) ENSMUST00000158491.1 ENSMUST00000158491.2 uc292kjs.1 uc292kjs.2 uc292kjs.1 uc292kjs.2 
ENSMUST00000158492.3 Gm25903 ENSMUST00000158492.3 Gm25903 (from geneSymbol) ENSMUST00000158492.1 ENSMUST00000158492.2 uc289elp.1 uc289elp.2 uc289elp.1 uc289elp.2 
ENSMUST00000158494.3 Gm25901 ENSMUST00000158494.3 Gm25901 (from geneSymbol) ENSMUST00000158494.1 ENSMUST00000158494.2 uc288wjs.1 uc288wjs.2 uc288wjs.1 uc288wjs.2 
ENSMUST00000158498.3 Gm26404 ENSMUST00000158498.3 Gm26404 (from geneSymbol) ENSMUST00000158498.1 ENSMUST00000158498.2 uc290ett.1 uc290ett.2 uc290ett.1 uc290ett.2 
ENSMUST00000158499.4 Gm26402 ENSMUST00000158499.4 Gm26402 (from geneSymbol) ENSMUST00000158499.1 ENSMUST00000158499.2 ENSMUST00000158499.3 uc287sgc.1 uc287sgc.2 uc287sgc.1 uc287sgc.2 
ENSMUST00000158500.3 Gm26403 ENSMUST00000158500.3 Gm26403 (from geneSymbol) ENSMUST00000158500.1 ENSMUST00000158500.2 LF201437 uc289pgs.1 uc289pgs.2 uc289pgs.1 uc289pgs.2 
ENSMUST00000158502.4 Gm26401 ENSMUST00000158502.4 Gm26401 (from geneSymbol) ENSMUST00000158502.1 ENSMUST00000158502.2 ENSMUST00000158502.3 uc292mwp.1 uc292mwp.2 uc292mwp.1 uc292mwp.2 
ENSMUST00000158503.3 Gm26406 ENSMUST00000158503.3 Gm26406 (from geneSymbol) ENSMUST00000158503.1 ENSMUST00000158503.2 uc292qlm.1 uc292qlm.2 uc292qlm.1 uc292qlm.2 
ENSMUST00000158505.3 Gm24770 ENSMUST00000158505.3 Gm24770 (from geneSymbol) ENSMUST00000158505.1 ENSMUST00000158505.2 uc288wcl.1 uc288wcl.2 uc288wcl.1 uc288wcl.2 
ENSMUST00000158508.4 Gm24771 ENSMUST00000158508.4 Gm24771 (from geneSymbol) ENSMUST00000158508.1 ENSMUST00000158508.2 ENSMUST00000158508.3 uc288xno.1 uc288xno.2 uc288xno.1 uc288xno.2 
ENSMUST00000158511.4 Gm24922 ENSMUST00000158511.4 Gm24922 (from geneSymbol) ENSMUST00000158511.1 ENSMUST00000158511.2 ENSMUST00000158511.3 uc288fvs.1 uc288fvs.2 uc288fvs.1 uc288fvs.2 
ENSMUST00000158514.3 Mir1964 ENSMUST00000158514.3 microRNA 1964 (from RefSeq NR_035490.1) ENSMUST00000158514.1 ENSMUST00000158514.2 NR_035490 uc012fhj.1 uc012fhj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610490.1 [ECO:0000345] ##Evidence-Data-END## uc012fhj.1 uc012fhj.2 
ENSMUST00000158518.4 Gm25268 ENSMUST00000158518.4 Gm25268 (from geneSymbol) ENSMUST00000158518.1 ENSMUST00000158518.2 ENSMUST00000158518.3 uc289ruv.1 uc289ruv.2 uc289ruv.1 uc289ruv.2 
ENSMUST00000158519.3 Gm25264 ENSMUST00000158519.3 Gm25264 (from geneSymbol) ENSMUST00000158519.1 ENSMUST00000158519.2 uc289vyz.1 uc289vyz.2 uc289vyz.1 uc289vyz.2 
ENSMUST00000158522.3 Gm25267 ENSMUST00000158522.3 Gm25267 (from geneSymbol) ENSMUST00000158522.1 ENSMUST00000158522.2 uc292bim.1 uc292bim.2 uc292bim.1 uc292bim.2 
ENSMUST00000158526.3 Mir1950 ENSMUST00000158526.3 microRNA 1950 (from RefSeq NR_035473.1) ENSMUST00000158526.1 ENSMUST00000158526.2 NR_035473 uc056zif.1 uc056zif.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zif.1 uc056zif.2 
ENSMUST00000158527.4 Gm22424 ENSMUST00000158527.4 Gm22424 (from geneSymbol) ENSMUST00000158527.1 ENSMUST00000158527.2 ENSMUST00000158527.3 uc290akt.1 uc290akt.2 uc290akt.1 uc290akt.2 
ENSMUST00000158528.4 Gm23579 ENSMUST00000158528.4 Gm23579 (from geneSymbol) ENSMUST00000158528.1 ENSMUST00000158528.2 ENSMUST00000158528.3 uc288gyp.1 uc288gyp.2 uc288gyp.1 uc288gyp.2 
ENSMUST00000158530.3 Gm23582 ENSMUST00000158530.3 Gm23582 (from geneSymbol) ENSMUST00000158530.1 ENSMUST00000158530.2 uc287wwe.1 uc287wwe.2 uc287wwe.1 uc287wwe.2 
ENSMUST00000158531.3 Gm23581 ENSMUST00000158531.3 Gm23581 (from geneSymbol) ENSMUST00000158531.1 ENSMUST00000158531.2 uc289pio.1 uc289pio.2 uc289pio.1 uc289pio.2 
ENSMUST00000158532.3 Gm22425 ENSMUST00000158532.3 Gm22425 (from geneSymbol) ENSMUST00000158532.1 ENSMUST00000158532.2 uc291fgh.1 uc291fgh.2 uc291fgh.1 uc291fgh.2 
ENSMUST00000158536.3 Gm24130 ENSMUST00000158536.3 Gm24130 (from geneSymbol) ENSMUST00000158536.1 ENSMUST00000158536.2 uc288nxp.1 uc288nxp.2 uc288nxp.1 uc288nxp.2 
ENSMUST00000158537.4 Gm24129 ENSMUST00000158537.4 Gm24129 (from geneSymbol) ENSMUST00000158537.1 ENSMUST00000158537.2 ENSMUST00000158537.3 uc290wru.1 uc290wru.2 uc290wru.1 uc290wru.2 
ENSMUST00000158539.3 Gm24131 ENSMUST00000158539.3 Gm24131 (from geneSymbol) ENSMUST00000158539.1 ENSMUST00000158539.2 uc291bjh.1 uc291bjh.2 uc291bjh.1 uc291bjh.2 
ENSMUST00000158543.3 Gm24128 ENSMUST00000158543.3 Gm24128 (from geneSymbol) ENSMUST00000158543.1 ENSMUST00000158543.2 uc289bti.1 uc289bti.2 uc289bti.1 uc289bti.2 
ENSMUST00000158546.3 Gm22430 ENSMUST00000158546.3 Gm22430 (from geneSymbol) ENSMUST00000158546.1 ENSMUST00000158546.2 uc292pyh.1 uc292pyh.2 uc292pyh.1 uc292pyh.2 
ENSMUST00000158549.3 Gm22434 ENSMUST00000158549.3 Gm22434 (from geneSymbol) ENSMUST00000158549.1 ENSMUST00000158549.2 uc287ngz.1 uc287ngz.2 uc287ngz.1 uc287ngz.2 
ENSMUST00000158550.3 Gm22433 ENSMUST00000158550.3 Gm22433 (from geneSymbol) ENSMUST00000158550.1 ENSMUST00000158550.2 uc290fpi.1 uc290fpi.2 uc290fpi.1 uc290fpi.2 
ENSMUST00000158553.3 Gm22429 ENSMUST00000158553.3 Gm22429 (from geneSymbol) ENSMUST00000158553.1 ENSMUST00000158553.2 uc289fjb.1 uc289fjb.2 uc289fjb.1 uc289fjb.2 
ENSMUST00000158554.4 Gm22428 ENSMUST00000158554.4 Gm22428 (from geneSymbol) ENSMUST00000158554.1 ENSMUST00000158554.2 ENSMUST00000158554.3 uc292byq.1 uc292byq.2 uc292byq.1 uc292byq.2 
ENSMUST00000158557.3 Gm22945 ENSMUST00000158557.3 Gm22945 (from geneSymbol) ENSMUST00000158557.1 ENSMUST00000158557.2 uc287uqq.1 uc287uqq.2 uc287uqq.1 uc287uqq.2 
ENSMUST00000158558.4 Gm22946 ENSMUST00000158558.4 Gm22946 (from geneSymbol) ENSMUST00000158558.1 ENSMUST00000158558.2 ENSMUST00000158558.3 uc291iqo.1 uc291iqo.2 uc291iqo.1 uc291iqo.2 
ENSMUST00000158559.3 Gm22947 ENSMUST00000158559.3 Gm22947 (from geneSymbol) ENSMUST00000158559.1 ENSMUST00000158559.2 uc288aph.1 uc288aph.2 uc288aph.1 uc288aph.2 
ENSMUST00000158563.4 Gm22942 ENSMUST00000158563.4 Gm22942 (from geneSymbol) ENSMUST00000158563.1 ENSMUST00000158563.2 ENSMUST00000158563.3 uc290isu.1 uc290isu.2 uc290isu.1 uc290isu.2 
ENSMUST00000158564.3 Gm24149 ENSMUST00000158564.3 Gm24149 (from geneSymbol) DQ558729 ENSMUST00000158564.1 ENSMUST00000158564.2 uc289jwa.1 uc289jwa.2 uc289jwa.1 uc289jwa.2 
ENSMUST00000158565.3 Gm25771 ENSMUST00000158565.3 Gm25771 (from geneSymbol) ENSMUST00000158565.1 ENSMUST00000158565.2 uc287lhb.1 uc287lhb.2 uc287lhb.1 uc287lhb.2 
ENSMUST00000158566.3 Gm25770 ENSMUST00000158566.3 Gm25770 (from geneSymbol) ENSMUST00000158566.1 ENSMUST00000158566.2 uc292qsg.1 uc292qsg.2 uc292qsg.1 uc292qsg.2 
ENSMUST00000158569.3 Gm25769 ENSMUST00000158569.3 Gm25769 (from geneSymbol) ENSMUST00000158569.1 ENSMUST00000158569.2 uc290nhj.1 uc290nhj.2 uc290nhj.1 uc290nhj.2 
ENSMUST00000158570.3 Gm25768 ENSMUST00000158570.3 Gm25768 (from geneSymbol) ENSMUST00000158570.1 ENSMUST00000158570.2 uc290wfq.1 uc290wfq.2 uc290wfq.1 uc290wfq.2 
ENSMUST00000158572.3 Gm25767 ENSMUST00000158572.3 Gm25767 (from geneSymbol) ENSMUST00000158572.1 ENSMUST00000158572.2 uc290uxa.1 uc290uxa.2 uc290uxa.1 uc290uxa.2 
ENSMUST00000158578.3 Gm26211 ENSMUST00000158578.3 Gm26211 (from geneSymbol) ENSMUST00000158578.1 ENSMUST00000158578.2 uc288fnj.1 uc288fnj.2 uc288fnj.1 uc288fnj.2 
ENSMUST00000158579.3 Mir1927 ENSMUST00000158579.3 microRNA 1927 (from RefSeq NR_035448.1) ENSMUST00000158579.1 ENSMUST00000158579.2 NR_035448 uc056yeo.1 uc056yeo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yeo.1 uc056yeo.2 
ENSMUST00000158580.3 Gm24577 ENSMUST00000158580.3 Gm24577 (from geneSymbol) ENSMUST00000158580.1 ENSMUST00000158580.2 uc292pqs.1 uc292pqs.2 uc292pqs.1 uc292pqs.2 
ENSMUST00000158581.4 Gm26214 ENSMUST00000158581.4 Gm26214 (from geneSymbol) ENSMUST00000158581.1 ENSMUST00000158581.2 ENSMUST00000158581.3 uc287kwt.1 uc287kwt.2 uc287kwt.1 uc287kwt.2 
ENSMUST00000158585.3 Gm23386 ENSMUST00000158585.3 Gm23386 (from geneSymbol) ENSMUST00000158585.1 ENSMUST00000158585.2 uc287wup.1 uc287wup.2 uc287wup.1 uc287wup.2 
ENSMUST00000158589.3 Mir1931 ENSMUST00000158589.3 microRNA 1931 (from RefSeq NR_035452.1) ENSMUST00000158589.1 ENSMUST00000158589.2 NR_035452 uc011xlp.1 uc011xlp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610461.1 [ECO:0000345] ##Evidence-Data-END## uc011xlp.1 uc011xlp.2 
ENSMUST00000158590.3 Gm25119 ENSMUST00000158590.3 Gm25119 (from geneSymbol) ENSMUST00000158590.1 ENSMUST00000158590.2 uc289gvu.1 uc289gvu.2 uc289gvu.1 uc289gvu.2 
ENSMUST00000158594.3 Mir1963 ENSMUST00000158594.3 microRNA 1963 (from RefSeq NR_035489.1) ENSMUST00000158594.1 ENSMUST00000158594.2 NR_035489 uc012fgz.1 uc012fgz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610489.1 [ECO:0000345] ##Evidence-Data-END## uc012fgz.1 uc012fgz.2 
ENSMUST00000158595.3 Gm22074 ENSMUST00000158595.3 Gm22074 (from geneSymbol) ENSMUST00000158595.1 ENSMUST00000158595.2 uc290dtg.1 uc290dtg.2 uc290dtg.1 uc290dtg.2 
ENSMUST00000158597.4 Gm25049 ENSMUST00000158597.4 Gm25049 (from geneSymbol) ENSMUST00000158597.1 ENSMUST00000158597.2 ENSMUST00000158597.3 uc289jne.1 uc289jne.2 uc289jne.1 uc289jne.2 
ENSMUST00000158604.4 Gm25043 ENSMUST00000158604.4 Gm25043 (from geneSymbol) ENSMUST00000158604.1 ENSMUST00000158604.2 ENSMUST00000158604.3 uc288lvh.1 uc288lvh.2 uc288lvh.1 uc288lvh.2 
ENSMUST00000158605.3 Gm22203 ENSMUST00000158605.3 Gm22203 (from geneSymbol) ENSMUST00000158605.1 ENSMUST00000158605.2 uc291oqj.1 uc291oqj.2 uc291oqj.1 uc291oqj.2 
ENSMUST00000158606.3 Gm23112 ENSMUST00000158606.3 Gm23112 (from geneSymbol) ENSMUST00000158606.1 ENSMUST00000158606.2 uc290dxa.1 uc290dxa.2 uc290dxa.1 uc290dxa.2 
ENSMUST00000158610.3 Gm23119 ENSMUST00000158610.3 Gm23119 (from geneSymbol) ENSMUST00000158610.1 ENSMUST00000158610.2 uc289pqk.1 uc289pqk.2 uc289pqk.1 uc289pqk.2 
ENSMUST00000158612.3 Gm22206 ENSMUST00000158612.3 Gm22206 (from geneSymbol) ENSMUST00000158612.1 ENSMUST00000158612.2 uc290krq.1 uc290krq.2 uc290krq.1 uc290krq.2 
ENSMUST00000158614.3 Gm22200 ENSMUST00000158614.3 Gm22200 (from geneSymbol) ENSMUST00000158614.1 ENSMUST00000158614.2 uc289oqu.1 uc289oqu.2 uc289oqu.1 uc289oqu.2 
ENSMUST00000158617.3 Gm24056 ENSMUST00000158617.3 Gm24056 (from geneSymbol) ENSMUST00000158617.1 ENSMUST00000158617.2 uc288zhu.1 uc288zhu.2 uc288zhu.1 uc288zhu.2 
ENSMUST00000158627.3 Gm25715 ENSMUST00000158627.3 Gm25715 (from geneSymbol) ENSMUST00000158627.1 ENSMUST00000158627.2 uc289ftu.1 uc289ftu.2 uc289ftu.1 uc289ftu.2 
ENSMUST00000158630.3 Snora78 ENSMUST00000158630.3 small nucleolar RNA, H/ACA box 7 (from RefSeq NR_028515.1) ENSMUST00000158630.1 ENSMUST00000158630.2 NR_028515 uc012amq.1 uc012amq.2 uc012amq.3 uc012amq.1 uc012amq.2 uc012amq.3 
ENSMUST00000158632.3 Gm25718 ENSMUST00000158632.3 Gm25718 (from geneSymbol) ENSMUST00000158632.1 ENSMUST00000158632.2 uc289pui.1 uc289pui.2 uc289pui.1 uc289pui.2 
ENSMUST00000158633.3 Gm25711 ENSMUST00000158633.3 Gm25711 (from geneSymbol) ENSMUST00000158633.1 ENSMUST00000158633.2 uc288xef.1 uc288xef.2 uc288xef.1 uc288xef.2 
ENSMUST00000158635.3 Mir1929 ENSMUST00000158635.3 microRNA 1929 (from RefSeq NR_035450.1) ENSMUST00000158635.1 ENSMUST00000158635.2 NR_035450 uc011xdn.1 uc011xdn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610459.1 [ECO:0000345] ##Evidence-Data-END## uc011xdn.1 uc011xdn.2 
ENSMUST00000158636.3 Mir669n ENSMUST00000158636.3 microRNA 669n (from RefSeq NR_130332.1) ENSMUST00000158636.1 ENSMUST00000158636.2 NR_130332 uc056zuc.1 uc056zuc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zuc.1 uc056zuc.2 
ENSMUST00000158637.3 Gm22893 ENSMUST00000158637.3 Gm22893 (from geneSymbol) ENSMUST00000158637.1 ENSMUST00000158637.2 uc291gjy.1 uc291gjy.2 uc291gjy.1 uc291gjy.2 
ENSMUST00000158639.4 Gm22889 ENSMUST00000158639.4 Gm22889 (from geneSymbol) ENSMUST00000158639.1 ENSMUST00000158639.2 ENSMUST00000158639.3 uc290agx.1 uc290agx.2 uc290agx.1 uc290agx.2 
ENSMUST00000158640.2 Gm22888 ENSMUST00000158640.2 Gm22888 (from geneSymbol) ENSMUST00000158640.1 LF194338 uc290lwu.1 uc290lwu.2 uc290lwu.1 uc290lwu.2 
ENSMUST00000158642.3 Gm22890 ENSMUST00000158642.3 Gm22890 (from geneSymbol) ENSMUST00000158642.1 ENSMUST00000158642.2 uc289ajd.1 uc289ajd.2 uc289ajd.1 uc289ajd.2 
ENSMUST00000158643.3 Mir1961 ENSMUST00000158643.3 microRNA 1961 (from RefSeq NR_035487.1) ENSMUST00000158643.1 ENSMUST00000158643.2 NR_035487 uc012dyw.1 uc012dyw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012dyw.1 uc012dyw.2 
ENSMUST00000158644.3 Gm26468 ENSMUST00000158644.3 Gm26468 (from geneSymbol) ENSMUST00000158644.1 ENSMUST00000158644.2 uc290kmx.1 uc290kmx.2 uc290kmx.1 uc290kmx.2 
ENSMUST00000158646.3 Gm24552 ENSMUST00000158646.3 Gm24552 (from geneSymbol) ENSMUST00000158646.1 ENSMUST00000158646.2 uc291spy.1 uc291spy.2 uc291spy.1 uc291spy.2 
ENSMUST00000158647.3 Gm24549 ENSMUST00000158647.3 Gm24549 (from geneSymbol) ENSMUST00000158647.1 ENSMUST00000158647.2 uc289weg.1 uc289weg.2 uc289weg.1 uc289weg.2 
ENSMUST00000158649.3 Gm24547 ENSMUST00000158649.3 Gm24547 (from geneSymbol) ENSMUST00000158649.1 ENSMUST00000158649.2 uc287lgz.1 uc287lgz.2 uc287lgz.1 uc287lgz.2 
ENSMUST00000158650.3 Gm24548 ENSMUST00000158650.3 Gm24548 (from geneSymbol) ENSMUST00000158650.1 ENSMUST00000158650.2 uc287ihx.1 uc287ihx.2 uc287ihx.1 uc287ihx.2 
ENSMUST00000158652.4 Gm24546 ENSMUST00000158652.4 Gm24546 (from geneSymbol) ENSMUST00000158652.1 ENSMUST00000158652.2 ENSMUST00000158652.3 uc292est.1 uc292est.2 uc292est.1 uc292est.2 
ENSMUST00000158653.3 Gm24553 ENSMUST00000158653.3 Gm24553 (from geneSymbol) ENSMUST00000158653.1 ENSMUST00000158653.2 uc287kyd.1 uc287kyd.2 uc287kyd.1 uc287kyd.2 
ENSMUST00000158654.3 Gm24554 ENSMUST00000158654.3 Gm24554 (from geneSymbol) ENSMUST00000158654.1 ENSMUST00000158654.2 uc288xis.1 uc288xis.2 uc288xis.1 uc288xis.2 
ENSMUST00000158656.3 Scarna6 ENSMUST00000158656.3 small Cajal body-specific RNA 6 (from RefSeq NR_028519.2) ENSMUST00000158656.1 ENSMUST00000158656.2 NR_028519 uc011wor.1 uc011wor.2 uc011wor.3 uc011wor.1 uc011wor.2 uc011wor.3 
ENSMUST00000158659.3 Gm26029 ENSMUST00000158659.3 Gm26029 (from geneSymbol) ENSMUST00000158659.1 ENSMUST00000158659.2 uc292qkr.1 uc292qkr.2 uc292qkr.1 uc292qkr.2 
ENSMUST00000158662.3 Gm22944 ENSMUST00000158662.3 Gm22944 (from geneSymbol) ENSMUST00000158662.1 ENSMUST00000158662.2 uc290dse.1 uc290dse.2 uc290dse.1 uc290dse.2 
ENSMUST00000158663.3 Gm26022 ENSMUST00000158663.3 Gm26022 (from geneSymbol) ENSMUST00000158663.1 ENSMUST00000158663.2 uc291hna.1 uc291hna.2 uc291hna.1 uc291hna.2 
ENSMUST00000158664.3 Gm26021 ENSMUST00000158664.3 Gm26021 (from geneSymbol) ENSMUST00000158664.1 ENSMUST00000158664.2 uc291dal.1 uc291dal.2 uc291dal.1 uc291dal.2 
ENSMUST00000158665.3 Gm23207 ENSMUST00000158665.3 Gm23207 (from geneSymbol) ENSMUST00000158665.1 ENSMUST00000158665.2 uc289oio.1 uc289oio.2 uc289oio.1 uc289oio.2 
ENSMUST00000158668.4 Gm23210 ENSMUST00000158668.4 Gm23210 (from geneSymbol) ENSMUST00000158668.1 ENSMUST00000158668.2 ENSMUST00000158668.3 uc289gdy.1 uc289gdy.2 uc289gdy.1 uc289gdy.2 
ENSMUST00000158669.3 Mir2139 ENSMUST00000158669.3 microRNA 2139 (from RefSeq NR_035519.1) ENSMUST00000158669.1 ENSMUST00000158669.2 NR_035519 uc290rfq.1 uc290rfq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc290rfq.1 uc290rfq.2 
ENSMUST00000158671.4 Gm23205 ENSMUST00000158671.4 Gm23205 (from geneSymbol) ENSMUST00000158671.1 ENSMUST00000158671.2 ENSMUST00000158671.3 uc289owq.1 uc289owq.2 uc289owq.1 uc289owq.2 
ENSMUST00000158674.3 Gm24637 ENSMUST00000158674.3 Gm24637 (from geneSymbol) ENSMUST00000158674.1 ENSMUST00000158674.2 uc287nka.1 uc287nka.2 uc287nka.1 uc287nka.2 
ENSMUST00000158677.3 Gm26208 ENSMUST00000158677.3 Gm26208 (from geneSymbol) ENSMUST00000158677.1 ENSMUST00000158677.2 uc291yug.1 uc291yug.2 uc291yug.1 uc291yug.2 
ENSMUST00000158679.3 Gm24844 ENSMUST00000158679.3 Gm24844 (from geneSymbol) ENSMUST00000158679.1 ENSMUST00000158679.2 uc288wzm.1 uc288wzm.2 uc288wzm.1 uc288wzm.2 
ENSMUST00000158682.4 Gm24843 ENSMUST00000158682.4 Gm24843 (from geneSymbol) ENSMUST00000158682.1 ENSMUST00000158682.2 ENSMUST00000158682.3 uc291isa.1 uc291isa.2 uc291isa.1 uc291isa.2 
ENSMUST00000158683.2 Gm24837 ENSMUST00000158683.2 Gm24837 (from geneSymbol) ENSMUST00000158683.1 LF194338 uc290lww.1 uc290lww.2 uc290lww.1 uc290lww.2 
ENSMUST00000158684.3 Gm24838 ENSMUST00000158684.3 Gm24838 (from geneSymbol) ENSMUST00000158684.1 ENSMUST00000158684.2 uc292bdy.1 uc292bdy.2 uc292bdy.1 uc292bdy.2 
ENSMUST00000158685.3 Gm23181 ENSMUST00000158685.3 Gm23181 (from geneSymbol) ENSMUST00000158685.1 ENSMUST00000158685.2 uc287kri.1 uc287kri.2 uc287kri.1 uc287kri.2 
ENSMUST00000158686.3 Gm23180 ENSMUST00000158686.3 Gm23180 (from geneSymbol) ENSMUST00000158686.1 ENSMUST00000158686.2 uc289far.1 uc289far.2 uc289far.1 uc289far.2 
ENSMUST00000158688.4 Gm23182 ENSMUST00000158688.4 Gm23182 (from geneSymbol) ENSMUST00000158688.1 ENSMUST00000158688.2 ENSMUST00000158688.3 uc287vsl.1 uc287vsl.2 uc287vsl.1 uc287vsl.2 
ENSMUST00000158689.3 Gm23185 ENSMUST00000158689.3 Gm23185 (from geneSymbol) ENSMUST00000158689.1 ENSMUST00000158689.2 uc288xzf.1 uc288xzf.2 uc288xzf.1 uc288xzf.2 
ENSMUST00000158692.3 Snord123 ENSMUST00000158692.3 small nucleolar RNA, C/D box 123 (from RefSeq NR_028575.2) ENSMUST00000158692.1 ENSMUST00000158692.2 NR_028575 uc029sog.1 uc029sog.2 uc029sog.3 uc029sog.1 uc029sog.2 uc029sog.3 
ENSMUST00000158695.3 Gm25976 ENSMUST00000158695.3 Gm25976 (from geneSymbol) ENSMUST00000158695.1 ENSMUST00000158695.2 uc288xdx.1 uc288xdx.2 uc288xdx.1 uc288xdx.2 
ENSMUST00000158696.3 Gm22523 ENSMUST00000158696.3 Gm22523 (from geneSymbol) ENSMUST00000158696.1 ENSMUST00000158696.2 uc290qpz.1 uc290qpz.2 uc290qpz.1 uc290qpz.2 
ENSMUST00000158697.4 Gm25977 ENSMUST00000158697.4 Gm25977 (from geneSymbol) ENSMUST00000158697.1 ENSMUST00000158697.2 ENSMUST00000158697.3 uc290ljx.1 uc290ljx.2 uc290ljx.1 uc290ljx.2 
ENSMUST00000158699.3 Mir1936 ENSMUST00000158699.3 microRNA 1936 (from RefSeq NR_035457.1) ENSMUST00000158699.1 ENSMUST00000158699.2 NR_035457 uc011yqn.1 uc011yqn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610465.1 [ECO:0000345] ##Evidence-Data-END## uc011yqn.1 uc011yqn.2 
ENSMUST00000158702.2 Gm25975 ENSMUST00000158702.2 Gm25975 (from geneSymbol) ENSMUST00000158702.1 uc290lmw.1 uc290lmw.2 uc290lmw.1 uc290lmw.2 
ENSMUST00000158706.3 Gm24345 ENSMUST00000158706.3 Gm24345 (from geneSymbol) ENSMUST00000158706.1 ENSMUST00000158706.2 uc288wes.1 uc288wes.2 uc288wes.1 uc288wes.2 
ENSMUST00000158708.3 Gm24343 ENSMUST00000158708.3 Gm24343 (from geneSymbol) ENSMUST00000158708.1 ENSMUST00000158708.2 uc287pqz.1 uc287pqz.2 uc287pqz.1 uc287pqz.2 
ENSMUST00000158709.4 Gm24349 ENSMUST00000158709.4 Gm24349 (from geneSymbol) ENSMUST00000158709.1 ENSMUST00000158709.2 ENSMUST00000158709.3 uc287ica.1 uc287ica.2 uc287ica.1 uc287ica.2 
ENSMUST00000158710.4 Gm24348 ENSMUST00000158710.4 Gm24348 (from geneSymbol) ENSMUST00000158710.1 ENSMUST00000158710.2 ENSMUST00000158710.3 uc291ehv.1 uc291ehv.2 uc291ehv.1 uc291ehv.2 
ENSMUST00000158711.3 Gm24347 ENSMUST00000158711.3 Gm24347 (from geneSymbol) ENSMUST00000158711.1 ENSMUST00000158711.2 uc292idq.1 uc292idq.2 uc292idq.1 uc292idq.2 
ENSMUST00000158721.4 Gm22663 ENSMUST00000158721.4 Gm22663 (from geneSymbol) ENSMUST00000158721.1 ENSMUST00000158721.2 ENSMUST00000158721.3 uc288ggz.1 uc288ggz.2 uc288ggz.1 uc288ggz.2 
ENSMUST00000158724.2 Gm22670 ENSMUST00000158724.2 Gm22670 (from geneSymbol) ENSMUST00000158724.1 uc290mpp.1 uc290mpp.2 uc290mpp.1 uc290mpp.2 
ENSMUST00000158725.3 Gm25487 ENSMUST00000158725.3 Gm25487 (from geneSymbol) ENSMUST00000158725.1 ENSMUST00000158725.2 uc290exe.1 uc290exe.2 uc290exe.1 uc290exe.2 
ENSMUST00000158726.3 Gm25486 ENSMUST00000158726.3 Gm25486 (from geneSymbol) ENSMUST00000158726.1 ENSMUST00000158726.2 uc288imb.1 uc288imb.2 uc288imb.1 uc288imb.2 
ENSMUST00000158727.3 Gm25489 ENSMUST00000158727.3 Gm25489 (from geneSymbol) ENSMUST00000158727.1 ENSMUST00000158727.2 uc289weh.1 uc289weh.2 uc289weh.1 uc289weh.2 
ENSMUST00000158732.3 Mir2137 ENSMUST00000158732.3 microRNA 2137 (from RefSeq NR_035517.1) ENSMUST00000158732.1 ENSMUST00000158732.2 NR_035517 uc012hjy.1 uc012hjy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012hjy.1 uc012hjy.2 
ENSMUST00000158734.3 Gm25490 ENSMUST00000158734.3 Gm25490 (from geneSymbol) ENSMUST00000158734.1 ENSMUST00000158734.2 uc287wsc.1 uc287wsc.2 uc287wsc.1 uc287wsc.2 
ENSMUST00000158739.3 Gm23822 ENSMUST00000158739.3 Gm23822 (from geneSymbol) ENSMUST00000158739.1 ENSMUST00000158739.2 uc290tie.1 uc290tie.2 uc290tie.1 uc290tie.2 
ENSMUST00000158744.3 Gm23819 ENSMUST00000158744.3 Gm23819 (from geneSymbol) ENSMUST00000158744.1 ENSMUST00000158744.2 uc287vno.1 uc287vno.2 uc287vno.1 uc287vno.2 
ENSMUST00000158745.4 Gm22140 ENSMUST00000158745.4 Gm22140 (from geneSymbol) ENSMUST00000158745.1 ENSMUST00000158745.2 ENSMUST00000158745.3 uc291zfc.1 uc291zfc.2 uc291zfc.1 uc291zfc.2 
ENSMUST00000158746.3 Mir1938 ENSMUST00000158746.3 microRNA 1938 (from RefSeq NR_035459.1) ENSMUST00000158746.1 ENSMUST00000158746.2 NR_035459 uc011ylq.1 uc011ylq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610466.1 [ECO:0000345] ##Evidence-Data-END## uc011ylq.1 uc011ylq.2 
ENSMUST00000158747.3 Gm22139 ENSMUST00000158747.3 Gm22139 (from geneSymbol) ENSMUST00000158747.1 ENSMUST00000158747.2 uc292qkf.1 uc292qkf.2 uc292qkf.1 uc292qkf.2 
ENSMUST00000158748.3 Gm22138 ENSMUST00000158748.3 Gm22138 (from geneSymbol) ENSMUST00000158748.1 ENSMUST00000158748.2 uc292jjb.1 uc292jjb.2 uc292jjb.1 uc292jjb.2 
ENSMUST00000158750.3 Snord107 ENSMUST00000158750.3 Snord107 (from geneSymbol) ENSMUST00000158750.1 ENSMUST00000158750.2 uc291qvv.1 uc291qvv.2 uc291qvv.1 uc291qvv.2 
ENSMUST00000158755.4 Gm24677 ENSMUST00000158755.4 Gm24677 (from geneSymbol) ENSMUST00000158755.1 ENSMUST00000158755.2 ENSMUST00000158755.3 uc292ahw.1 uc292ahw.2 uc292ahw.1 uc292ahw.2 
ENSMUST00000158756.4 Gm24678 ENSMUST00000158756.4 Gm24678 (from geneSymbol) ENSMUST00000158756.1 ENSMUST00000158756.2 ENSMUST00000158756.3 uc290pnk.1 uc290pnk.2 uc290pnk.1 uc290pnk.2 
ENSMUST00000158759.3 Gm24680 ENSMUST00000158759.3 Gm24680 (from geneSymbol) ENSMUST00000158759.1 ENSMUST00000158759.2 uc288wbu.1 uc288wbu.2 uc288wbu.1 uc288wbu.2 
ENSMUST00000158760.3 Gm24681 ENSMUST00000158760.3 Gm24681 (from geneSymbol) ENSMUST00000158760.1 ENSMUST00000158760.2 uc289fkc.1 uc289fkc.2 uc289fkc.1 uc289fkc.2 
ENSMUST00000158761.4 Gm25989 ENSMUST00000158761.4 Gm25989 (from geneSymbol) ENSMUST00000158761.1 ENSMUST00000158761.2 ENSMUST00000158761.3 uc289etn.1 uc289etn.2 uc289etn.1 uc289etn.2 
ENSMUST00000158762.3 Gm24679 ENSMUST00000158762.3 Gm24679 (from geneSymbol) ENSMUST00000158762.1 ENSMUST00000158762.2 uc289pkw.1 uc289pkw.2 uc289pkw.1 uc289pkw.2 
ENSMUST00000158765.3 Gm23021 ENSMUST00000158765.3 Gm23021 (from geneSymbol) ENSMUST00000158765.1 ENSMUST00000158765.2 uc287wty.1 uc287wty.2 uc287wty.1 uc287wty.2 
ENSMUST00000158768.3 Gm23022 ENSMUST00000158768.3 Gm23022 (from geneSymbol) ENSMUST00000158768.1 ENSMUST00000158768.2 uc290vck.1 uc290vck.2 uc290vck.1 uc290vck.2 
ENSMUST00000158769.3 Gm23025 ENSMUST00000158769.3 Gm23025 (from geneSymbol) ENSMUST00000158769.1 ENSMUST00000158769.2 uc290ghp.1 uc290ghp.2 uc290ghp.1 uc290ghp.2 
ENSMUST00000158774.4 Gm23312 ENSMUST00000158774.4 Gm23312 (from geneSymbol) ENSMUST00000158774.1 ENSMUST00000158774.2 ENSMUST00000158774.3 uc290tby.1 uc290tby.2 uc290tby.1 uc290tby.2 
ENSMUST00000158781.3 Mir2136 ENSMUST00000158781.3 microRNA 2136 (from RefSeq NR_035516.1) ENSMUST00000158781.1 ENSMUST00000158781.2 NR_035516 uc012gzl.1 uc012gzl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012gzl.1 uc012gzl.2 
ENSMUST00000158782.3 Gm24878 ENSMUST00000158782.3 Gm24878 (from geneSymbol) ENSMUST00000158782.1 ENSMUST00000158782.2 uc290uwy.1 uc290uwy.2 uc290uwy.1 uc290uwy.2 
ENSMUST00000158783.4 Gm24885 ENSMUST00000158783.4 Gm24885 (from geneSymbol) ENSMUST00000158783.1 ENSMUST00000158783.2 ENSMUST00000158783.3 uc289zby.1 uc289zby.2 uc289zby.1 uc289zby.2 
ENSMUST00000158784.3 Gm24884 ENSMUST00000158784.3 Gm24884 (from geneSymbol) ENSMUST00000158784.1 ENSMUST00000158784.2 uc290nml.1 uc290nml.2 uc290nml.1 uc290nml.2 
ENSMUST00000158788.3 Gm22013 ENSMUST00000158788.3 Gm22013 (from geneSymbol) ENSMUST00000158788.1 ENSMUST00000158788.2 uc288lob.1 uc288lob.2 uc288lob.1 uc288lob.2 
ENSMUST00000158790.3 Gm22011 ENSMUST00000158790.3 Gm22011 (from geneSymbol) ENSMUST00000158790.1 ENSMUST00000158790.2 uc290wpw.1 uc290wpw.2 uc290wpw.1 uc290wpw.2 
ENSMUST00000158791.4 Gm22116 ENSMUST00000158791.4 Gm22116 (from geneSymbol) ENSMUST00000158791.1 ENSMUST00000158791.2 ENSMUST00000158791.3 uc288tjp.1 uc288tjp.2 uc288tjp.1 uc288tjp.2 
ENSMUST00000158792.3 Gm22009 ENSMUST00000158792.3 Gm22009 (from geneSymbol) ENSMUST00000158792.1 ENSMUST00000158792.2 uc290fwo.1 uc290fwo.2 uc290fwo.1 uc290fwo.2 
ENSMUST00000158795.4 Gm27934 ENSMUST00000158795.4 Gm27934 (from geneSymbol) ENSMUST00000158795.1 ENSMUST00000158795.2 ENSMUST00000158795.3 uc287ixp.1 uc287ixp.2 uc287ixp.1 uc287ixp.2 
ENSMUST00000158797.3 Gm26008 ENSMUST00000158797.3 Gm26008 (from geneSymbol) ENSMUST00000158797.1 ENSMUST00000158797.2 NR_171170 uc291dqs.1 uc291dqs.2 uc291dqs.1 uc291dqs.2 
ENSMUST00000158798.3 Gm26007 ENSMUST00000158798.3 Gm26007 (from geneSymbol) ENSMUST00000158798.1 ENSMUST00000158798.2 uc292rqi.1 uc292rqi.2 uc292rqi.1 uc292rqi.2 
ENSMUST00000158799.3 Mir1930 ENSMUST00000158799.3 microRNA 1930 (from RefSeq NR_035451.1) ENSMUST00000158799.1 ENSMUST00000158799.2 NR_035451 uc011xhh.1 uc011xhh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610460.1 [ECO:0000345] ##Evidence-Data-END## uc011xhh.1 uc011xhh.2 
ENSMUST00000158800.4 Gm26006 ENSMUST00000158800.4 Gm26006 (from geneSymbol) ENSMUST00000158800.1 ENSMUST00000158800.2 ENSMUST00000158800.3 uc288wct.1 uc288wct.2 uc288wct.1 uc288wct.2 
ENSMUST00000158802.3 Gm26005 ENSMUST00000158802.3 Gm26005 (from geneSymbol) ENSMUST00000158802.1 ENSMUST00000158802.2 uc289njc.1 uc289njc.2 uc289njc.1 uc289njc.2 
ENSMUST00000158806.4 Gm23196 ENSMUST00000158806.4 Gm23196 (from geneSymbol) ENSMUST00000158806.1 ENSMUST00000158806.2 ENSMUST00000158806.3 uc290jun.1 uc290jun.2 uc290jun.1 uc290jun.2 
ENSMUST00000158807.3 Mir1966 ENSMUST00000158807.3 microRNA 1966 (from RefSeq NR_035492.1) ENSMUST00000158807.1 ENSMUST00000158807.2 NR_035492 uc012gjm.1 uc012gjm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610491.1 [ECO:0000345] ##Evidence-Data-END## uc012gjm.1 uc012gjm.2 
ENSMUST00000158812.3 Gm23199 ENSMUST00000158812.3 Gm23199 (from geneSymbol) ENSMUST00000158812.1 ENSMUST00000158812.2 uc292qvf.1 uc292qvf.2 uc292qvf.1 uc292qvf.2 
ENSMUST00000158813.3 Gm23194 ENSMUST00000158813.3 Gm23194 (from geneSymbol) ENSMUST00000158813.1 ENSMUST00000158813.2 uc287zfw.1 uc287zfw.2 uc287zfw.1 uc287zfw.2 
ENSMUST00000158814.3 Gm23195 ENSMUST00000158814.3 Gm23195 (from geneSymbol) ENSMUST00000158814.1 ENSMUST00000158814.2 uc288iik.1 uc288iik.2 uc288iik.1 uc288iik.2 
ENSMUST00000158815.3 Gm22416 ENSMUST00000158815.3 Gm22416 (from geneSymbol) ENSMUST00000158815.1 ENSMUST00000158815.2 uc289gun.1 uc289gun.2 uc289gun.1 uc289gun.2 
ENSMUST00000158817.4 Gm22529 ENSMUST00000158817.4 Gm22529 (from geneSymbol) ENSMUST00000158817.1 ENSMUST00000158817.2 ENSMUST00000158817.3 uc291cxx.1 uc291cxx.2 uc291cxx.1 uc291cxx.2 
ENSMUST00000158819.3 Gm22531 ENSMUST00000158819.3 Gm22531 (from geneSymbol) ENSMUST00000158819.1 ENSMUST00000158819.2 uc290gdi.1 uc290gdi.2 uc290gdi.1 uc290gdi.2 
ENSMUST00000158820.3 Gm22530 ENSMUST00000158820.3 Gm22530 (from geneSymbol) ENSMUST00000158820.1 ENSMUST00000158820.2 uc291fzq.1 uc291fzq.2 uc291fzq.1 uc291fzq.2 
ENSMUST00000158827.4 Gm24223 ENSMUST00000158827.4 Gm24223 (from geneSymbol) ENSMUST00000158827.1 ENSMUST00000158827.2 ENSMUST00000158827.3 uc290ijd.1 uc290ijd.2 uc290ijd.1 uc290ijd.2 
ENSMUST00000158829.3 Gm24228 ENSMUST00000158829.3 Gm24228 (from geneSymbol) ENSMUST00000158829.1 ENSMUST00000158829.2 uc289ofj.1 uc289ofj.2 uc289ofj.1 uc289ofj.2 
ENSMUST00000158830.3 Gm24229 ENSMUST00000158830.3 Gm24229 (from geneSymbol) ENSMUST00000158830.1 ENSMUST00000158830.2 uc288wjo.1 uc288wjo.2 uc288wjo.1 uc288wjo.2 
ENSMUST00000158833.4 Gm24221 ENSMUST00000158833.4 Gm24221 (from geneSymbol) ENSMUST00000158833.1 ENSMUST00000158833.2 ENSMUST00000158833.3 uc290bdu.1 uc290bdu.2 uc290bdu.1 uc290bdu.2 
ENSMUST00000158835.3 Gm23699 ENSMUST00000158835.3 Gm23699 (from geneSymbol) ENSMUST00000158835.1 ENSMUST00000158835.2 uc288dns.1 uc288dns.2 uc288dns.1 uc288dns.2 
ENSMUST00000158836.3 Gm23698 ENSMUST00000158836.3 Gm23698 (from geneSymbol) ENSMUST00000158836.1 ENSMUST00000158836.2 uc287uug.1 uc287uug.2 uc287uug.1 uc287uug.2 
ENSMUST00000158839.3 Gm23703 ENSMUST00000158839.3 Gm23703 (from geneSymbol) ENSMUST00000158839.1 ENSMUST00000158839.2 uc291hjc.1 uc291hjc.2 uc291hjc.1 uc291hjc.2 
ENSMUST00000158843.4 Rnu7-ps1 ENSMUST00000158843.4 Rnu7-ps1 (from geneSymbol) ENSMUST00000158843.1 ENSMUST00000158843.2 ENSMUST00000158843.3 uc288kes.1 uc288kes.2 uc288kes.1 uc288kes.2 
ENSMUST00000158848.3 Gm25369 ENSMUST00000158848.3 Gm25369 (from geneSymbol) ENSMUST00000158848.1 ENSMUST00000158848.2 uc287pgk.1 uc287pgk.2 uc287pgk.1 uc287pgk.2 
ENSMUST00000158851.4 Gm25364 ENSMUST00000158851.4 Gm25364 (from geneSymbol) ENSMUST00000158851.1 ENSMUST00000158851.2 ENSMUST00000158851.3 uc288dmv.1 uc288dmv.2 uc288dmv.1 uc288dmv.2 
ENSMUST00000158854.3 Gm25362 ENSMUST00000158854.3 Gm25362 (from geneSymbol) ENSMUST00000158854.1 ENSMUST00000158854.2 uc288cwq.1 uc288cwq.2 uc288cwq.1 uc288cwq.2 
ENSMUST00000158859.3 Gm24735 ENSMUST00000158859.3 Gm24735 (from geneSymbol) ENSMUST00000158859.1 ENSMUST00000158859.2 uc291ysn.1 uc291ysn.2 uc291ysn.1 uc291ysn.2 
ENSMUST00000158861.3 Gm24737 ENSMUST00000158861.3 Gm24737 (from geneSymbol) ENSMUST00000158861.1 ENSMUST00000158861.2 uc288pen.1 uc288pen.2 uc288pen.1 uc288pen.2 
ENSMUST00000158864.3 Gm24732 ENSMUST00000158864.3 Gm24732 (from geneSymbol) ENSMUST00000158864.1 ENSMUST00000158864.2 uc287hbe.1 uc287hbe.2 uc287hbe.1 uc287hbe.2 
ENSMUST00000158868.4 Gm26361 ENSMUST00000158868.4 Gm26361 (from geneSymbol) ENSMUST00000158868.1 ENSMUST00000158868.2 ENSMUST00000158868.3 uc290hrd.1 uc290hrd.2 uc290hrd.1 uc290hrd.2 
ENSMUST00000158873.3 Gm26359 ENSMUST00000158873.3 Gm26359 (from geneSymbol) ENSMUST00000158873.1 ENSMUST00000158873.2 uc287rvl.1 uc287rvl.2 uc287rvl.1 uc287rvl.2 
ENSMUST00000158876.3 Gm23479 ENSMUST00000158876.3 Gm23479 (from geneSymbol) ENSMUST00000158876.1 ENSMUST00000158876.2 uc291sxv.1 uc291sxv.2 uc291sxv.1 uc291sxv.2 
ENSMUST00000158879.3 Gm23475 ENSMUST00000158879.3 Gm23475 (from geneSymbol) ENSMUST00000158879.1 ENSMUST00000158879.2 uc288yec.1 uc288yec.2 uc288yec.1 uc288yec.2 
ENSMUST00000158882.3 Gm23477 ENSMUST00000158882.3 Gm23477 (from geneSymbol) ENSMUST00000158882.1 ENSMUST00000158882.2 uc290fxn.1 uc290fxn.2 uc290fxn.1 uc290fxn.2 
ENSMUST00000158887.5 Gm26287 ENSMUST00000158887.5 Gm26287 (from geneSymbol) ENSMUST00000158887.1 ENSMUST00000158887.2 ENSMUST00000158887.3 ENSMUST00000158887.4 uc287imy.1 uc287imy.2 uc287imy.1 uc287imy.2 
ENSMUST00000158888.4 Gm24875 ENSMUST00000158888.4 Gm24875 (from geneSymbol) ENSMUST00000158888.1 ENSMUST00000158888.2 ENSMUST00000158888.3 uc289tst.1 uc289tst.2 uc289tst.1 uc289tst.2 
ENSMUST00000158889.3 Gm26291 ENSMUST00000158889.3 Gm26291 (from geneSymbol) ENSMUST00000158889.1 ENSMUST00000158889.2 uc289lyg.1 uc289lyg.2 uc289lyg.1 uc289lyg.2 
ENSMUST00000158895.4 Gm23831 ENSMUST00000158895.4 Gm23831 (from geneSymbol) ENSMUST00000158895.1 ENSMUST00000158895.2 ENSMUST00000158895.3 uc290eux.1 uc290eux.2 uc290eux.1 uc290eux.2 
ENSMUST00000158899.3 Gm22327 ENSMUST00000158899.3 Gm22327 (from geneSymbol) ENSMUST00000158899.1 ENSMUST00000158899.2 uc289jmv.1 uc289jmv.2 uc289jmv.1 uc289jmv.2 
ENSMUST00000158902.4 Gm26133 ENSMUST00000158902.4 Gm26133 (from geneSymbol) ENSMUST00000158902.1 ENSMUST00000158902.2 ENSMUST00000158902.3 uc288lqy.1 uc288lqy.2 uc288lqy.1 uc288lqy.2 
ENSMUST00000158903.3 Gm22324 ENSMUST00000158903.3 Gm22324 (from geneSymbol) ENSMUST00000158903.1 ENSMUST00000158903.2 uc292aep.1 uc292aep.2 uc292aep.1 uc292aep.2 
ENSMUST00000158905.4 Gm25163 ENSMUST00000158905.4 Gm25163 (from geneSymbol) ENSMUST00000158905.1 ENSMUST00000158905.2 ENSMUST00000158905.3 uc292ipc.1 uc292ipc.2 uc292ipc.1 uc292ipc.2 
ENSMUST00000158906.4 Gm25162 ENSMUST00000158906.4 Gm25162 (from geneSymbol) ENSMUST00000158906.1 ENSMUST00000158906.2 ENSMUST00000158906.3 uc288vca.1 uc288vca.2 uc288vca.1 uc288vca.2 
ENSMUST00000158909.3 Gm25166 ENSMUST00000158909.3 Gm25166 (from geneSymbol) ENSMUST00000158909.1 ENSMUST00000158909.2 uc287gsc.1 uc287gsc.2 uc287gsc.1 uc287gsc.2 
ENSMUST00000158913.3 Gm25161 ENSMUST00000158913.3 Gm25161 (from geneSymbol) ENSMUST00000158913.1 ENSMUST00000158913.2 uc291eby.1 uc291eby.2 uc291eby.1 uc291eby.2 
ENSMUST00000158914.3 Gm25160 ENSMUST00000158914.3 Gm25160 (from geneSymbol) ENSMUST00000158914.1 ENSMUST00000158914.2 uc292cnc.1 uc292cnc.2 uc292cnc.1 uc292cnc.2 
ENSMUST00000158916.3 Gm25834 ENSMUST00000158916.3 Gm25834 (from geneSymbol) ENSMUST00000158916.1 ENSMUST00000158916.2 uc289pha.1 uc289pha.2 uc289pha.1 uc289pha.2 
ENSMUST00000158917.3 Gm25835 ENSMUST00000158917.3 Gm25835 (from geneSymbol) ENSMUST00000158917.1 ENSMUST00000158917.2 uc287zis.1 uc287zis.2 uc287zis.1 uc287zis.2 
ENSMUST00000158918.3 Gm25836 ENSMUST00000158918.3 Gm25836 (from geneSymbol) ENSMUST00000158918.1 ENSMUST00000158918.2 uc290nkf.1 uc290nkf.2 uc290nkf.1 uc290nkf.2 
ENSMUST00000158923.3 Gm25830 ENSMUST00000158923.3 Gm25830 (from geneSymbol) ENSMUST00000158923.1 ENSMUST00000158923.2 uc291zvj.1 uc291zvj.2 uc291zvj.1 uc291zvj.2 
ENSMUST00000158924.3 Gm25831 ENSMUST00000158924.3 Gm25831 (from geneSymbol) ENSMUST00000158924.1 ENSMUST00000158924.2 uc288wcr.1 uc288wcr.2 uc288wcr.1 uc288wcr.2 
ENSMUST00000158925.4 Gm24179 ENSMUST00000158925.4 Gm24179 (from geneSymbol) ENSMUST00000158925.1 ENSMUST00000158925.2 ENSMUST00000158925.3 uc287vkg.1 uc287vkg.2 uc287vkg.1 uc287vkg.2 
ENSMUST00000158926.3 Gm24178 ENSMUST00000158926.3 Gm24178 (from geneSymbol) ENSMUST00000158926.1 ENSMUST00000158926.2 uc292jrn.1 uc292jrn.2 uc292jrn.1 uc292jrn.2 
ENSMUST00000158927.2 Gm24177 ENSMUST00000158927.2 Gm24177 (from geneSymbol) ENSMUST00000158927.1 uc290mug.1 uc290mug.2 uc290mug.1 uc290mug.2 
ENSMUST00000158928.3 Gm24176 ENSMUST00000158928.3 Gm24176 (from geneSymbol) ENSMUST00000158928.1 ENSMUST00000158928.2 uc287gvn.1 uc287gvn.2 uc287gvn.1 uc287gvn.2 
ENSMUST00000158930.3 Mir1933 ENSMUST00000158930.3 microRNA 1933 (from RefSeq NR_035454.1) ENSMUST00000158930.1 ENSMUST00000158930.2 NR_035454 uc011xrz.1 uc011xrz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610463.1 [ECO:0000345] ##Evidence-Data-END## uc011xrz.1 uc011xrz.2 
ENSMUST00000158931.3 Gm24175 ENSMUST00000158931.3 Gm24175 (from geneSymbol) ENSMUST00000158931.1 ENSMUST00000158931.2 uc291jam.1 uc291jam.2 uc291jam.1 uc291jam.2 
ENSMUST00000158934.4 Gm23421 ENSMUST00000158934.4 Gm23421 (from geneSymbol) ENSMUST00000158934.1 ENSMUST00000158934.2 ENSMUST00000158934.3 uc289kkg.1 uc289kkg.2 uc289kkg.1 uc289kkg.2 
ENSMUST00000158935.3 Gm24668 ENSMUST00000158935.3 Gm24668 (from geneSymbol) ENSMUST00000158935.1 ENSMUST00000158935.2 uc289avq.1 uc289avq.2 uc289avq.1 uc289avq.2 
ENSMUST00000158936.3 Gm24669 ENSMUST00000158936.3 Gm24669 (from geneSymbol) ENSMUST00000158936.1 ENSMUST00000158936.2 uc291zrq.1 uc291zrq.2 uc291zrq.1 uc291zrq.2 
ENSMUST00000158937.4 Gm24666 ENSMUST00000158937.4 Gm24666 (from geneSymbol) ENSMUST00000158937.1 ENSMUST00000158937.2 ENSMUST00000158937.3 uc290tbo.1 uc290tbo.2 uc290tbo.1 uc290tbo.2 
ENSMUST00000158938.3 Gm24667 ENSMUST00000158938.3 Gm24667 (from geneSymbol) ENSMUST00000158938.1 ENSMUST00000158938.2 uc289ciw.1 uc289ciw.2 uc289ciw.1 uc289ciw.2 
ENSMUST00000158945.3 Mir669m-1 ENSMUST00000158945.3 microRNA 669m-1 (from RefSeq NR_035474.1) ENSMUST00000158945.1 ENSMUST00000158945.2 NR_035474 uc056zkt.1 uc056zkt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zkt.1 uc056zkt.2 
ENSMUST00000158946.3 Gm23008 ENSMUST00000158946.3 Gm23008 (from geneSymbol) AK085695 ENSMUST00000158946.1 ENSMUST00000158946.2 uc292eye.1 uc292eye.2 uc292eye.1 uc292eye.2 
ENSMUST00000158950.3 Gm23005 ENSMUST00000158950.3 Gm23005 (from geneSymbol) ENSMUST00000158950.1 ENSMUST00000158950.2 uc290bhm.1 uc290bhm.2 uc290bhm.1 uc290bhm.2 
ENSMUST00000158955.3 Gm23340 ENSMUST00000158955.3 Gm23340 (from geneSymbol) ENSMUST00000158955.1 ENSMUST00000158955.2 uc288lnp.1 uc288lnp.2 uc288lnp.1 uc288lnp.2 
ENSMUST00000158956.3 Gm23341 ENSMUST00000158956.3 Gm23341 (from geneSymbol) ENSMUST00000158956.1 ENSMUST00000158956.2 uc287yrg.1 uc287yrg.2 uc287yrg.1 uc287yrg.2 
ENSMUST00000158959.4 Gm23337 ENSMUST00000158959.4 Gm23337 (from geneSymbol) ENSMUST00000158959.1 ENSMUST00000158959.2 ENSMUST00000158959.3 uc290ezv.1 uc290ezv.2 uc290ezv.1 uc290ezv.2 
ENSMUST00000158960.2 Gm23338 ENSMUST00000158960.2 Gm23338 (from geneSymbol) ENSMUST00000158960.1 uc290lva.1 uc290lva.2 uc290lva.1 uc290lva.2 
ENSMUST00000158962.4 Gm23339 ENSMUST00000158962.4 Gm23339 (from geneSymbol) ENSMUST00000158962.1 ENSMUST00000158962.2 ENSMUST00000158962.3 uc291hnt.1 uc291hnt.2 uc291hnt.1 uc291hnt.2 
ENSMUST00000158964.3 Gm23343 ENSMUST00000158964.3 Gm23343 (from geneSymbol) ENSMUST00000158964.1 ENSMUST00000158964.2 uc288xye.1 uc288xye.2 uc288xye.1 uc288xye.2 
ENSMUST00000158965.3 Gm26160 ENSMUST00000158965.3 Gm26160 (from geneSymbol) ENSMUST00000158965.1 ENSMUST00000158965.2 uc291jiv.1 uc291jiv.2 uc291jiv.1 uc291jiv.2 
ENSMUST00000158966.3 Gm24352 ENSMUST00000158966.3 Gm24352 (from geneSymbol) ENSMUST00000158966.1 ENSMUST00000158966.2 uc290pjf.1 uc290pjf.2 uc290pjf.1 uc290pjf.2 
ENSMUST00000158968.3 Gm26159 ENSMUST00000158968.3 Gm26159 (from geneSymbol) ENSMUST00000158968.1 ENSMUST00000158968.2 uc289cgt.1 uc289cgt.2 uc289cgt.1 uc289cgt.2 
ENSMUST00000158978.3 Gm23059 ENSMUST00000158978.3 Gm23059 (from geneSymbol) ENSMUST00000158978.1 ENSMUST00000158978.2 uc288gqi.1 uc288gqi.2 uc288gqi.1 uc288gqi.2 
ENSMUST00000158981.3 Gm22501 ENSMUST00000158981.3 Gm22501 (from geneSymbol) ENSMUST00000158981.1 ENSMUST00000158981.2 uc289yxw.1 uc289yxw.2 uc289yxw.1 uc289yxw.2 
ENSMUST00000158982.3 Gm22500 ENSMUST00000158982.3 Gm22500 (from geneSymbol) ENSMUST00000158982.1 ENSMUST00000158982.2 uc289erd.1 uc289erd.2 uc289erd.1 uc289erd.2 
ENSMUST00000158983.4 Gm22503 ENSMUST00000158983.4 Gm22503 (from geneSymbol) ENSMUST00000158983.1 ENSMUST00000158983.2 ENSMUST00000158983.3 uc287qyg.1 uc287qyg.2 uc287qyg.1 uc287qyg.2 
ENSMUST00000158987.3 Gm22708 ENSMUST00000158987.3 Gm22708 (from geneSymbol) ENSMUST00000158987.1 ENSMUST00000158987.2 uc290dnz.1 uc290dnz.2 uc290dnz.1 uc290dnz.2 
ENSMUST00000158989.4 Gm23505 ENSMUST00000158989.4 Gm23505 (from geneSymbol) ENSMUST00000158989.1 ENSMUST00000158989.2 ENSMUST00000158989.3 uc289wbr.1 uc289wbr.2 uc289wbr.1 uc289wbr.2 
ENSMUST00000158990.3 Gm23774 ENSMUST00000158990.3 Gm23774 (from geneSymbol) ENSMUST00000158990.1 ENSMUST00000158990.2 uc288ljq.1 uc288ljq.2 uc288ljq.1 uc288ljq.2 
ENSMUST00000158992.3 Scarna10 ENSMUST00000158992.3 Scarna10 (from geneSymbol) AF357346 ENSMUST00000158992.1 ENSMUST00000158992.2 uc291jac.1 uc291jac.2 uc291jac.1 uc291jac.2 
ENSMUST00000159000.3 Gm25443 ENSMUST00000159000.3 Gm25443 (from geneSymbol) AF357342 ENSMUST00000159000.1 ENSMUST00000159000.2 uc289qzq.1 uc289qzq.2 uc289qzq.1 uc289qzq.2 
ENSMUST00000159004.2 Mrgpra2a ENSMUST00000159004.2 MAS-related GPR, member A2A, transcript variant 1 (from RefSeq NM_001384209.1) A0A0R4J1Z0 A0A0R4J1Z0_MOUSE ENSMUST00000159004.1 Mrgpra2a NM_001384209 uc009hag.1 uc009hag.2 uc009hag.3 uc009hag.4 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009hag.1 uc009hag.2 uc009hag.3 uc009hag.4 
ENSMUST00000159031.2 0610012D04Rik ENSMUST00000159031.2 0610012D04Rik (from geneSymbol) AK002586 ENSMUST00000159031.1 uc057kyy.1 uc057kyy.2 uc057kyy.1 uc057kyy.2 
ENSMUST00000159038.8 Mfsd4a ENSMUST00000159038.8 major facilitator superfamily domain containing 4A, transcript variant b (from RefSeq NM_001114662.1) ENSMUST00000159038.1 ENSMUST00000159038.2 ENSMUST00000159038.3 ENSMUST00000159038.4 ENSMUST00000159038.5 ENSMUST00000159038.6 ENSMUST00000159038.7 MFD4A_MOUSE Mfsd4 Mfsd4a NM_001114662 Q6PDC8 Q8C3M3 Q8C816 Q8CAF5 uc011wru.1 uc011wru.2 uc011wru.3 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6PDC8-1; Sequence=Displayed; Name=2; IsoId=Q6PDC8-2; Sequence=VSP_022541, VSP_022543; Name=3; IsoId=Q6PDC8-3; Sequence=VSP_022542; Name=4; IsoId=Q6PDC8-4; Sequence=VSP_022543; Belongs to the major facilitator superfamily. Sequence=BAC30158.1; Type=Erroneous initiation; Evidence=; glucose transmembrane transporter activity cellular_component integral component of plasma membrane membrane integral component of membrane transmembrane transport glucose transmembrane transport uc011wru.1 uc011wru.2 uc011wru.3 
ENSMUST00000159039.2 Cmtm1 ENSMUST00000159039.2 CKLF-like MARVEL transmembrane domain containing 1 (from RefSeq NM_181990.2) B7ZP21 B7ZP21_MOUSE Cmtm1 ENSMUST00000159039.1 NM_181990 uc012gix.1 uc012gix.2 uc012gix.3 Membrane ; Multi- pass membrane protein molecular_function biological_process membrane integral component of membrane uc012gix.1 uc012gix.2 uc012gix.3 
ENSMUST00000159040.3 AU015336 ENSMUST00000159040.3 expressed sequence AU015336 (from RefSeq NR_188879.1) ENSMUST00000159040.1 ENSMUST00000159040.2 NR_188879 uc289dvy.1 uc289dvy.2 uc289dvy.1 uc289dvy.2 
ENSMUST00000159062.8 Fbxo41 ENSMUST00000159062.8 F-box protein 41, transcript variant 3 (from RefSeq NM_001289675.1) D6Ertd538e ENSMUST00000159062.1 ENSMUST00000159062.2 ENSMUST00000159062.3 ENSMUST00000159062.4 ENSMUST00000159062.5 ENSMUST00000159062.6 ENSMUST00000159062.7 FBX41_MOUSE Kiaa1940 NM_001289675 Q6NS60 Q6P7W4 Q6ZPG1 uc033isv.1 uc033isv.2 uc033isv.3 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Directly interacts with SKP1 and CUL1. cellular_component biological_process uc033isv.1 uc033isv.2 uc033isv.3 
ENSMUST00000159067.5 Gm43720 ENSMUST00000159067.5 Cell surface proteoglycan. (from UniProt E0CXM8) AK132558 E0CXM8 E0CXM8_MOUSE ENSMUST00000159067.1 ENSMUST00000159067.2 ENSMUST00000159067.3 ENSMUST00000159067.4 Gm43720 uc291bca.1 uc291bca.2 Cell surface proteoglycan. Cell membrane ; Lipid-anchor, GPI-anchor Belongs to the glypican family. extracellular region plasma membrane smoothened signaling pathway regulation of signal transduction cell surface membrane cell migration anchored component of membrane synapse anchored component of plasma membrane regulation of protein localization to membrane uc291bca.1 uc291bca.2 
ENSMUST00000159081.8 Commd1 ENSMUST00000159081.8 COMM domain containing 1, transcript variant 1 (from RefSeq NM_144514.2) COMD1_MOUSE ENSMUST00000159081.1 ENSMUST00000159081.2 ENSMUST00000159081.3 ENSMUST00000159081.4 ENSMUST00000159081.5 ENSMUST00000159081.6 ENSMUST00000159081.7 Murr1 NM_144514 Q3V012 Q80WG2 Q80Z41 Q8BNL9 Q8K2S9 Q8K4M5 uc007iel.1 uc007iel.2 uc007iel.3 Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF- kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride- sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Involved in the regulation of HIF1A- mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1. Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner. Monomer, homodimer. Can form heterodimers with other COMM domain-containing proteins but only certain combinations may exist in vivo. Interacts (via COMM domain) with COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8 and COMMD10 (via COMM domain). Identified in a complex with an E3 ubiquitin ligase complex composed of TCEB1/elongin C, CUL2, SOCS1 and RBX1; in the complex interacts directly with SOCS1 and CUL2. Interacts directly with ATP7B (via the N-terminal region). Interacts with CCS, CDKN2A, RELA, REL, RELB, NFKB1/p105, NFKB2/p100, NFKBIB, SCNN1D, SCNN1B, CFTR, CLU, SGK1, AKT1, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, CUL7, HIF1A. Identified in a complex with NF-kappa-B. Interacts directly with SLC12A2. Interacts with CCDC22 and CCDC93; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain- containing proteins), CCDC22, CCDC93. Interacts with VPS35L; the interaction associates CCC complex with retriever complex. Interacts with ATP7A. Interacts with FAM107A; this interaction stabilizes COMMD1 in the nucleus. Nucleus Cytoplasm Endosome membrane Cytoplasmic vesicle Early endosome Recycling endosome Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins (By similarity). Ubiquitinated; undergoes both 'Lys-63'- and 'Lys-48'-linked polyubiquitination. Ubiquitinated by XIAP, leading to its proteasomal degradation (By similarity). copper ion binding protein binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding nucleus nucleoplasm cytoplasm endosome early endosome cytosol cellular copper ion homeostasis Golgi to plasma membrane transport endosome membrane protein transport membrane sodium channel inhibitor activity positive regulation of protein ubiquitination cytoplasmic vesicle Cul2-RING ubiquitin ligase complex protein destabilization negative regulation of NF-kappaB transcription factor activity regulation of proteasomal ubiquitin-dependent protein catabolic process low-density lipoprotein particle clearance cholesterol homeostasis identical protein binding protein homodimerization activity phosphatidylinositol-3,4-bisphosphate binding metal ion binding plasma membrane to endosome transport low-density lipoprotein particle receptor binding recycling endosome copper ion homeostasis phosphatidic acid binding phosphatidylinositol-3,5-bisphosphate binding regulation of plasma lipoprotein particle levels negative regulation of hypoxia-inducible factor-1alpha signaling pathway negative regulation of sodium ion transmembrane transport positive regulation of cholesterol import positive regulation of endosome to plasma membrane protein transport negative regulation of protein localization to cell surface positive regulation of protein localization to cell surface uc007iel.1 uc007iel.2 uc007iel.3 
ENSMUST00000159086.10 Zfp871 ENSMUST00000159086.10 zinc finger protein 871, transcript variant 1 (from RefSeq NM_172458.3) ENSMUST00000159086.1 ENSMUST00000159086.2 ENSMUST00000159086.3 ENSMUST00000159086.4 ENSMUST00000159086.5 ENSMUST00000159086.6 ENSMUST00000159086.7 ENSMUST00000159086.8 ENSMUST00000159086.9 G5E905 G5E905_MOUSE NM_172458 Zfp871 uc008bxm.1 uc008bxm.2 uc008bxm.3 uc008bxm.4 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008bxm.1 uc008bxm.2 uc008bxm.3 uc008bxm.4 
ENSMUST00000159108.3 Gm15825 ENSMUST00000159108.3 predicted gene 15825 (from RefSeq NR_151619.1) ENSMUST00000159108.1 ENSMUST00000159108.2 NR_151619 uc287gsw.1 uc287gsw.2 uc287gsw.1 uc287gsw.2 
ENSMUST00000159109.2 Zfp609 ENSMUST00000159109.2 zinc finger protein 609 (from RefSeq NM_172536.3) ENSMUST00000159109.1 Kiaa0295 NM_172536 Q05DD7 Q6PD47 Q6ZQE3 Q8BZ47 ZN609_MOUSE Znf609 uc009qdw.1 uc009qdw.2 uc009qdw.3 uc009qdw.4 Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation (PubMed:28344082). Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (PubMed:28041881). [Isoform 2]: Involved in regulation of myoblast proliferation during myogenesis. Interacts (via N-terminus) with NIPBL (PubMed:28041881). Interacts with the multiprotein complex Integrator (PubMed:28041881). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZ47-1; Sequence=Displayed; Name=2; IsoId=Q8BZ47-2; Sequence=VSP_059084, VSP_059085; Expressed in myoblasts (PubMed:28344082). Expressed in neurons in various brain regions, including striatum, prefrontal cortex, olfactory bulb, midbrain, cerebellum and hippocampus (PubMed:25921068). Expressed in neural stem cells (at protein level) (PubMed:28041881). Expressed in thymocytes (PubMed:23076336). Expressed in the developing brain at 12.5 dpc. At 14.5 dpc, becomes enriched in the ventricular zone and later, restricted to the progenitor population as cortical neurogenesis peaks. At this stage, not detected in the subventricular zone/intermediate zone (SVZ/IZ). At later stages, detected in the neurons of the cortical plate and in stem cells near the ventricular surface. Down-regulated by ZNF608 (PubMed:23076336). Isoform 2 is up- regulated during neuronal differentiation (PubMed:25921068). [Isoform 2]: Produced by a back-splicing reaction which joins the 5'-splice site of the first coding exon with the 3'-splice site of the upstream intron resulting in a circular RNA, called circ- ZNF609. The translation starts with the same initiator methionine as that of the linear transcript encoding isoform 1. The stop codon is created upon circularization. Sequence=BAC29549.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleic acid binding protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter multicellular organism development muscle organ development integrator complex positive regulation of T cell differentiation in thymus positive regulation of transcription from RNA polymerase II promoter metal ion binding regulation of myoblast proliferation positive regulation of neuron migration uc009qdw.1 uc009qdw.2 uc009qdw.3 uc009qdw.4 
ENSMUST00000159122.8 A630001G21Rik ENSMUST00000159122.8 A630001G21Rik (from geneSymbol) A630001G21Rik AK041675 ENSMUST00000159122.1 ENSMUST00000159122.2 ENSMUST00000159122.3 ENSMUST00000159122.4 ENSMUST00000159122.5 ENSMUST00000159122.6 ENSMUST00000159122.7 Q3UTB2 Q3UTB2_MOUSE uc287jya.1 uc287jya.2 molecular_function cellular_component nucleus biological_process uc287jya.1 uc287jya.2 
ENSMUST00000159124.8 Impdh1 ENSMUST00000159124.8 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (from UniProt P50096) AK047537 ENSMUST00000159124.1 ENSMUST00000159124.2 ENSMUST00000159124.3 ENSMUST00000159124.4 ENSMUST00000159124.5 ENSMUST00000159124.6 ENSMUST00000159124.7 IMDH1_MOUSE P50096 Q7TSG7 uc009bdb.1 uc009bdb.2 uc009bdb.3 uc009bdb.4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Reaction=H2O + IMP + NAD(+) = H(+) + NADH + XMP; Xref=Rhea:RHEA:11708, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57464, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58053; EC=1.1.1.205; Evidence=; Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence=; Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. Homotetramer. Cytoplasm Nucleus Belongs to the IMPDH/GMPR family. nucleotide binding nucleic acid binding DNA binding catalytic activity IMP dehydrogenase activity nucleus cytoplasm cytosol purine nucleotide biosynthetic process GMP biosynthetic process GTP biosynthetic process oxidoreductase activity lymphocyte proliferation metal ion binding oxidation-reduction process uc009bdb.1 uc009bdb.2 uc009bdb.3 uc009bdb.4 
ENSMUST00000159138.2 Gm16565 ENSMUST00000159138.2 Gm16565 (from geneSymbol) AK080019 ENSMUST00000159138.1 uc287nll.1 uc287nll.2 uc287nll.1 uc287nll.2 
ENSMUST00000159164.9 Gfi1 ENSMUST00000159164.9 Gfi1 (from geneSymbol) A0A0R4J292 A0A0R4J292_MOUSE ENSMUST00000159164.1 ENSMUST00000159164.2 ENSMUST00000159164.3 ENSMUST00000159164.4 ENSMUST00000159164.5 ENSMUST00000159164.6 ENSMUST00000159164.7 ENSMUST00000159164.8 Gfi1 KY467441 uc290xwj.1 uc290xwj.2 nucleic acid binding regulation of transcription, DNA-templated hemopoiesis regulation of histone H3-K4 methylation uc290xwj.1 uc290xwj.2 
ENSMUST00000159171.2 Fcrla ENSMUST00000159171.2 Fc receptor-like A, transcript variant 2 (from RefSeq NM_145141.2) ENSMUST00000159171.1 FCRLA_MOUSE Fcrl Fcrl1 Fcrlm1 Fcrx Freb NM_145141 Q3T9Q2 Q8K3U9 Q8VHP5 Q920A9 uc007dmq.1 uc007dmq.2 uc007dmq.3 uc007dmq.4 May be implicated in B-cell differentiation and lymphomagenesis. Monomer or homodimer; disulfide-linked. Q920A9; P39429: Traf2; NbExp=5; IntAct=EBI-646587, EBI-520016; Cytoplasm Note=Seems not to be secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q920A9-1; Sequence=Displayed; Name=2; IsoId=Q920A9-2; Sequence=VSP_017610; Highly expressed in spleen. Expressed in immature B-cell and B-cell lines. protein binding cytoplasm cell differentiation uc007dmq.1 uc007dmq.2 uc007dmq.3 uc007dmq.4 
ENSMUST00000159175.2 Ear10 ENSMUST00000159175.2 Belongs to the pancreatic ribonuclease family. (from UniProt Q923L6) ENSMUST00000159175.1 Ear10 Q923L6 Q923L6_MOUSE Raf2 uc288stk.1 uc288stk.2 Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity ribonuclease activity cellular_component hydrolase activity nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis uc288stk.1 uc288stk.2 
ENSMUST00000159193.8 Lyz3 ENSMUST00000159193.8 Belongs to the glycosyl hydrolase 22 family. (from UniProt Q8BM26) 9530003J23Rik AK035441 ENSMUST00000159193.1 ENSMUST00000159193.2 ENSMUST00000159193.3 ENSMUST00000159193.4 ENSMUST00000159193.5 ENSMUST00000159193.6 ENSMUST00000159193.7 Lyz3 Lyzf1 Q8BM26 Q8BM26_MOUSE uc007hcy.1 uc007hcy.2 uc007hcy.3 uc007hcy.4 Belongs to the glycosyl hydrolase 22 family. lysozyme activity defense response to Gram-negative bacterium defense response to Gram-positive bacterium uc007hcy.1 uc007hcy.2 uc007hcy.3 uc007hcy.4 
ENSMUST00000159200.2 Prrt4 ENSMUST00000159200.2 proline-rich transmembrane protein 4 (from RefSeq NM_001101443.1) B2RU40 E9QKZ9 ENSMUST00000159200.1 NM_001101443 PRRT4_MOUSE uc009bcz.1 uc009bcz.2 uc009bcz.3 uc009bcz.4 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009bcz.1 uc009bcz.2 uc009bcz.3 uc009bcz.4 
ENSMUST00000159213.2 Gm15699 ENSMUST00000159213.2 Gm15699 (from geneSymbol) ENSMUST00000159213.1 uc287kvk.1 uc287kvk.2 uc287kvk.1 uc287kvk.2 
ENSMUST00000159229.3 Gm6619 ENSMUST00000159229.3 predicted gene 6619 (from RefSeq NM_001347484.1) ENSMUST00000159229.1 ENSMUST00000159229.2 F6URP1 F6URP1_MOUSE Gm6619 NM_001347484 uc057lsj.1 uc057lsj.2 uc057lsj.3 molecular_function cellular_component biological_process uc057lsj.1 uc057lsj.2 uc057lsj.3 
ENSMUST00000159257.2 Gm15849 ENSMUST00000159257.2 Gm15849 (from geneSymbol) ENSMUST00000159257.1 uc287lrp.1 uc287lrp.2 uc287lrp.1 uc287lrp.2 
ENSMUST00000159260.2 D730045A05Rik ENSMUST00000159260.2 RIKEN cDNA D730045A05 gene (from RefSeq NR_045390.1) ENSMUST00000159260.1 NR_045390 uc029tpz.1 uc029tpz.2 uc029tpz.1 uc029tpz.2 
ENSMUST00000159268.3 Gm16302 ENSMUST00000159268.3 Gm16302 (from geneSymbol) ENSMUST00000159268.1 ENSMUST00000159268.2 uc292eok.1 uc292eok.2 uc292eok.3 uc292eok.1 uc292eok.2 uc292eok.3 
ENSMUST00000159271.2 Gm15722 ENSMUST00000159271.2 Gm15722 (from geneSymbol) ENSMUST00000159271.1 uc289alq.1 uc289alq.2 uc289alq.1 uc289alq.2 
ENSMUST00000159283.8 Manf ENSMUST00000159283.8 mesencephalic astrocyte-derived neurotrophic factor (from RefSeq NM_029103.4) Armet ENSMUST00000159283.1 ENSMUST00000159283.2 ENSMUST00000159283.3 ENSMUST00000159283.4 ENSMUST00000159283.5 ENSMUST00000159283.6 ENSMUST00000159283.7 MANF_MOUSE Manf NM_029103 Q3TMX5 Q9CXI5 uc009rku.1 uc009rku.2 uc009rku.3 Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O- sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions. Interacts with HSPA5; the interaction is direct (By similarity). Component of a complex containing at least CRELD2, MANF, MATN3 and PDIA4 (PubMed:23956175). Secreted doplasmic reticulum lumen Sarcoplasmic reticulum lumen Note=Retained in the endoplasmic reticulum (ER), and sarcoplasmic reticulum (SR) under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Strongly expressed in pancreatic islets and spermatocytes (at protein level). Expressed in chondrocytes (at protein level) (PubMed:23956175). Expressed from birth. By endoplasmic reticulum (ER) stress. The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. Belongs to the ARMET family. vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure molecular_function cellular_component extracellular region extracellular space endoplasmic reticulum endoplasmic reticulum lumen response to unfolded protein signal transduction growth factor activity lipid binding sarcoplasmic reticulum neuron projection development sarcoplasmic reticulum lumen dopaminergic neuron differentiation uc009rku.1 uc009rku.2 uc009rku.3 
ENSMUST00000159292.8 Osgep ENSMUST00000159292.8 O-sialoglycoprotein endopeptidase (from RefSeq NM_133676.2) A0A0R4J1Y3 A0A0R4J1Y3_MOUSE ENSMUST00000159292.1 ENSMUST00000159292.2 ENSMUST00000159292.3 ENSMUST00000159292.4 ENSMUST00000159292.5 ENSMUST00000159292.6 ENSMUST00000159292.7 NM_133676 Osgep uc007tlx.1 uc007tlx.2 uc007tlx.3 Reaction=adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA; Xref=Rhea:RHEA:37059, Rhea:RHEA-COMP:10162, Rhea:RHEA-COMP:10163, ChEBI:CHEBI:15378, ChEBI:CHEBI:73682, ChEBI:CHEBI:74411, ChEBI:CHEBI:74418, ChEBI:CHEBI:456215; EC=2.3.1.234; Evidence= Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 1 divalent metal cation per subunit. Cytoplasm Nucleus Belongs to the KAE1 / TsaD family. EKC/KEOPS complex tRNA threonylcarbamoyladenosine modification nucleus nucleoplasm cytoplasm plasma membrane tRNA processing nuclear speck transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups metal ion binding N(6)-L-threonylcarbamoyladenine synthase uc007tlx.1 uc007tlx.2 uc007tlx.3 
ENSMUST00000159294.9 Maml2 ENSMUST00000159294.9 mastermind like transcriptional coactivator 2, transcript variant 3 (from RefSeq NM_001410635.1) ENSMUST00000159294.1 ENSMUST00000159294.2 ENSMUST00000159294.3 ENSMUST00000159294.4 ENSMUST00000159294.5 ENSMUST00000159294.6 ENSMUST00000159294.7 ENSMUST00000159294.8 F6U238 F6U238_MOUSE Maml2 NM_001410635 uc057lyy.1 uc057lyy.2 uc057lyy.3 Nucleus speckle Belongs to the mastermind family. transcription coactivator activity nucleus nucleoplasm Notch signaling pathway positive regulation of transcription of Notch receptor target nuclear speck positive regulation of transcription from RNA polymerase II promoter uc057lyy.1 uc057lyy.2 uc057lyy.3 
ENSMUST00000159295.8 Atp5po ENSMUST00000159295.8 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. (from UniProt F7D3P8) AK080299 Atp5po ENSMUST00000159295.1 ENSMUST00000159295.2 ENSMUST00000159295.3 ENSMUST00000159295.4 ENSMUST00000159295.5 ENSMUST00000159295.6 ENSMUST00000159295.7 F7D3P8 F7D3P8_MOUSE uc289gcf.1 uc289gcf.2 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Mitochondrion inner membrane Nucleus Belongs to the ATPase delta chain family. Belongs to the DONSON family. ATP synthesis coupled proton transport proton-transporting ATP synthase activity, rotational mechanism uc289gcf.1 uc289gcf.2 
ENSMUST00000159296.2 Gm16132 ENSMUST00000159296.2 Gm16132 (from geneSymbol) ENSMUST00000159296.1 KY467672 uc288nte.1 uc288nte.2 uc288nte.1 uc288nte.2 
ENSMUST00000159309.2 9230117E06Rik ENSMUST00000159309.2 RIKEN cDNA 9230117E06 gene (from RefSeq NR_130988.1) ENSMUST00000159309.1 NR_130988 uc007ysi.1 uc007ysi.2 uc007ysi.3 uc007ysi.4 uc007ysi.1 uc007ysi.2 uc007ysi.3 uc007ysi.4 
ENSMUST00000159313.2 Gm16244 ENSMUST00000159313.2 Gm16244 (from geneSymbol) AK049068 ENSMUST00000159313.1 uc008hod.1 uc008hod.2 uc008hod.1 uc008hod.2 
ENSMUST00000159332.3 ENSMUSG00000121422 ENSMUST00000159332.3 ENSMUSG00000121422 (from geneSymbol) ENSMUST00000159332.1 ENSMUST00000159332.2 uc292csf.1 uc292csf.2 uc292csf.1 uc292csf.2 
ENSMUST00000159348.3 Zfta ENSMUST00000159348.3 zinc finger translocation associated, transcript variant 1 (from RefSeq NM_175381.7) ENSMUST00000159348.1 ENSMUST00000159348.2 NM_175381 Q4VA45 ZFTA_MOUSE Zfta uc008gkz.1 uc008gkz.2 uc008gkz.3 Sequence=AAH96549.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; molecular_function nucleic acid binding cellular_component negative regulation of transcription, DNA-templated uc008gkz.1 uc008gkz.2 uc008gkz.3 
ENSMUST00000159361.2 Gm15809 ENSMUST00000159361.2 Gm15809 (from geneSymbol) ENSMUST00000159361.1 uc288mjf.1 uc288mjf.2 uc288mjf.1 uc288mjf.2 
ENSMUST00000159364.3 Fcor ENSMUST00000159364.3 Foxo1 corepressor (from RefSeq NM_001357661.1) A5S7P8 ENSMUST00000159364.1 ENSMUST00000159364.2 FCOR_MOUSE NM_001357661 P0DJI6 uc009ksj.1 uc009ksj.2 uc009ksj.3 uc009ksj.4 uc009ksj.5 uc009ksj.6 Regulator of adipocytes that acts by repressing FOXO1 transcriptional activity. Acts by promoting acetylation of FOXO1, both by preventing the interaction between FOXO1 and SIRT1 deacetylase, and by mediating acetyltransferase activity in vitro. Regulates insulin sensitivity and energy metabolism. Interacts with FOXO1 (via N-terminal domain); the interaction is direct, occurs in a forskolin-independent manner that prevents SIRT1 binding to FOXO1. Interacts with FOXO3. Does not interact with FOXO4. P0DJI6; Q9R1E0: Foxo1; NbExp=12; IntAct=EBI-6126630, EBI-1371343; P0DJI6; Q9WVH4: Foxo3; NbExp=2; IntAct=EBI-6126630, EBI-6127038; Cytoplasm, cytosol Nucleus Note=Imported into the nucleus following phosphorylation at Thr-93 upon treatment of cells with forskolin. Probably shuttles between the nucleus and the cytoplasm. Expressed in adipocytes. Expressed in brown and white adipose tissue but not in liver. Protein levels in brown and white adipose tissues decrease following fasting (at protein level). Expressed in white and brown adipose tissues. Expressed in adipocytes. Not expressed in liver, skeletal muscle and brain. Up-regulated during adipocyte differentiation. Up-regulated by starved state in white (WAT) and brown (BAT) adipose tissues. Down- regulated during fasting in WAT and BAT. Up-regulated during cold exposure in BAT. Phosphorylated at Thr-93 by PKA, leading to import into the nucleus. Mice are glucose intolerant and insulin resistant, despite being leaner than wild-type mice. It is unclear whether the protein is conserved in human: no ortholog has been identified yet although antibodies against Fcor stain human tissues. temperature homeostasis cellular glucose homeostasis chromatin binding protein binding nucleus cytoplasm mitochondrion cytosol protein acetylation cellular response to starvation acetyltransferase activity transferase activity fat cell differentiation negative regulation of transcription, DNA-templated cellular response to cold energy homeostasis uc009ksj.1 uc009ksj.2 uc009ksj.3 uc009ksj.4 uc009ksj.5 uc009ksj.6 
ENSMUST00000159405.3 Pcdh1 ENSMUST00000159405.3 Pcdh1 (from geneSymbol) BC040402 ENSMUST00000159405.1 ENSMUST00000159405.2 Pcdh1 Q8CFX3 Q8CFX3_MOUSE uc289owk.1 uc289owk.2 calcium ion binding protein binding nucleus nucleolus plasma membrane integral component of plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell junction intracellular membrane-bounded organelle uc289owk.1 uc289owk.2 
ENSMUST00000159407.5 Gm15867 ENSMUST00000159407.5 predicted gene 15867 (from RefSeq NR_131748.1) ENSMUST00000159407.1 ENSMUST00000159407.2 ENSMUST00000159407.3 ENSMUST00000159407.4 NR_131748 uc007edt.1 uc007edt.2 uc007edt.3 uc007edt.4 uc007edt.5 uc007edt.6 uc007edt.7 uc007edt.1 uc007edt.2 uc007edt.3 uc007edt.4 uc007edt.5 uc007edt.6 uc007edt.7 
ENSMUST00000159412.10 1810021B22Rik ENSMUST00000159412.10 1810021B22Rik (from geneSymbol) AK007571 ENSMUST00000159412.1 ENSMUST00000159412.2 ENSMUST00000159412.3 ENSMUST00000159412.4 ENSMUST00000159412.5 ENSMUST00000159412.6 ENSMUST00000159412.7 ENSMUST00000159412.8 ENSMUST00000159412.9 uc289anl.1 uc289anl.2 uc289anl.3 uc289anl.4 uc289anl.1 uc289anl.2 uc289anl.3 uc289anl.4 
ENSMUST00000159417.2 Lypd1 ENSMUST00000159417.2 Ly6/Plaur domain containing 1, transcript variant 1 (from RefSeq NM_145100.4) ENSMUST00000159417.1 LYPD1_MOUSE Lypdc1 MNCb-0671 NM_145100 Q3V2X5 Q3V447 Q8BLC3 Q9JJ96 uc007ckj.1 uc007ckj.2 uc007ckj.3 Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2- containing nAChRs (PubMed:19246390). May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface (PubMed:26276394, PubMed:25716842). May be involved in the control of anxiety (PubMed:19246390). Interacts with CHRNA4 and nAChRs containing alpha-4:beta-2 (CHRNA4:CHRNB2) and alpha-7 (CHRNA7) subunits. Q8BLC3; O70174: Chrna4; NbExp=3; IntAct=EBI-14035010, EBI-10916203; Cell membrane ; Lipid-anchor, GPI- anchor Preferentially expressed in the nervous system. Expressed in embryonic and postnatal postmitotic central and peripheral neurons including subpopulations of motor neurons, sensory neurons, interneurons and neurons of the autonomous nervous system. Expressed around the growing nerves in the limb bud (PubMed:16236524). Expressed at high levels in specific brain regions such as the prefrontal cortex, amygdala, hippocampus, mediodorsal thalamus, dentate gyrus and specific brainstem nuclei (at protein level) (PubMed:19246390). Increased anxiety-like behaviors. Increased glutamatergic activity in response to nicotine in layer V neurons of the medial prefrontal cortex. behavioral fear response protein binding plasma membrane synaptic transmission, cholinergic membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding response to nicotine acetylcholine receptor signaling pathway negative regulation of protein localization to plasma membrane negative regulation of receptor activity uc007ckj.1 uc007ckj.2 uc007ckj.3 
ENSMUST00000159433.8 Umad1 ENSMUST00000159433.8 UMAP1-MVP12 associated (UMA) domain containing 1, transcript variant 2 (from RefSeq NM_001302354.1) E0CXP6 E0CXP6_MOUSE ENSMUST00000159433.1 ENSMUST00000159433.2 ENSMUST00000159433.3 ENSMUST00000159433.4 ENSMUST00000159433.5 ENSMUST00000159433.6 ENSMUST00000159433.7 Gm16039 NM_001302354 Umad1 uc009axm.1 uc009axm.2 uc009axm.3 uc009axm.4 uc009axm.5 molecular_function cellular_component biological_process uc009axm.1 uc009axm.2 uc009axm.3 uc009axm.4 uc009axm.5 
ENSMUST00000159445.2 Gm16268 ENSMUST00000159445.2 Gm16268 (from geneSymbol) AK048236 ENSMUST00000159445.1 uc287tvd.1 uc287tvd.2 uc287tvd.1 uc287tvd.2 
ENSMUST00000159455.3 Gm4491 ENSMUST00000159455.3 Gm4491 (from geneSymbol) AK034192 ENSMUST00000159455.1 ENSMUST00000159455.2 uc288uup.1 uc288uup.2 uc288uup.3 uc288uup.1 uc288uup.2 uc288uup.3 
ENSMUST00000159471.2 Gm16554 ENSMUST00000159471.2 Gm16554 (from geneSymbol) ENSMUST00000159471.1 uc289luq.1 uc289luq.2 uc289luq.1 uc289luq.2 
ENSMUST00000159472.3 Gm16116 ENSMUST00000159472.3 Gm16116 (from geneSymbol) ENSMUST00000159472.1 ENSMUST00000159472.2 KY468205 uc057lxy.1 uc057lxy.2 uc057lxy.3 uc057lxy.4 uc057lxy.1 uc057lxy.2 uc057lxy.3 uc057lxy.4 
ENSMUST00000159524.2 Spopfm3 ENSMUST00000159524.2 Belongs to the Tdpoz family. (from UniProt E0CXI6) E0CXI6 E0CXI6_MOUSE ENSMUST00000159524.1 Gm5286 Spopfm3 uc290hhm.1 uc290hhm.2 Belongs to the Tdpoz family. nucleus cytoplasm ubiquitin-dependent protein catabolic process regulation of proteolysis ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process uc290hhm.1 uc290hhm.2 
ENSMUST00000159551.8 Wtap ENSMUST00000159551.8 WT1 associating protein, transcript variant 4 (from RefSeq NM_001379058.1) E0CYH0 E0CYH0_MOUSE ENSMUST00000159551.1 ENSMUST00000159551.2 ENSMUST00000159551.3 ENSMUST00000159551.4 ENSMUST00000159551.5 ENSMUST00000159551.6 ENSMUST00000159551.7 NM_001379058 Wtap uc289hbo.1 uc289hbo.2 Belongs to the fl(2)d family. regulation of alternative mRNA splicing, via spliceosome nucleus nucleoplasm nuclear speck nuclear membrane MIS complex mRNA methylation uc289hbo.1 uc289hbo.2 
ENSMUST00000159556.8 Cabp2 ENSMUST00000159556.8 calcium binding protein 2, transcript variant 2 (from RefSeq NM_001160252.1) Cabp2 ENSMUST00000159556.1 ENSMUST00000159556.2 ENSMUST00000159556.3 ENSMUST00000159556.4 ENSMUST00000159556.5 ENSMUST00000159556.6 ENSMUST00000159556.7 G3XA16 G3XA16_MOUSE NM_001160252 uc008fyl.1 uc008fyl.2 uc008fyl.3 uc008fyl.4 uc008fyl.5 calcium ion binding uc008fyl.1 uc008fyl.2 uc008fyl.3 uc008fyl.4 uc008fyl.5 
ENSMUST00000159559.8 Wnk2 ENSMUST00000159559.8 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; (from UniProt E0CYT1) AK147550 E0CYT1 E0CYT1_MOUSE ENSMUST00000159559.1 ENSMUST00000159559.2 ENSMUST00000159559.3 ENSMUST00000159559.4 ENSMUST00000159559.5 ENSMUST00000159559.6 ENSMUST00000159559.7 Wnk2 uc288mqy.1 uc288mqy.2 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation uc288mqy.1 uc288mqy.2 
ENSMUST00000159565.8 4931429L15Rik ENSMUST00000159565.8 RIKEN cDNA 4931429L15 gene (from RefSeq NM_183104.2) 4931429L15Rik E9PVU2 E9PVU2_MOUSE ENSMUST00000159565.1 ENSMUST00000159565.2 ENSMUST00000159565.3 ENSMUST00000159565.4 ENSMUST00000159565.5 ENSMUST00000159565.6 ENSMUST00000159565.7 NM_183104 uc012gsl.1 uc012gsl.2 molecular_function cellular_component biological_process uc012gsl.1 uc012gsl.2 
ENSMUST00000159569.9 Zfp26 ENSMUST00000159569.9 zinc finger protein 26, transcript variant 19 (from RefSeq NR_176389.1) ENSMUST00000159569.1 ENSMUST00000159569.2 ENSMUST00000159569.3 ENSMUST00000159569.4 ENSMUST00000159569.5 ENSMUST00000159569.6 ENSMUST00000159569.7 ENSMUST00000159569.8 G3XA08 G3XA08_MOUSE NR_176389 Zfp26 uc009oim.1 uc009oim.2 uc009oim.3 uc009oim.4 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009oim.1 uc009oim.2 uc009oim.3 uc009oim.4 
ENSMUST00000159570.9 Efcc1 ENSMUST00000159570.9 EF hand and coiled-coil domain containing 1 (from RefSeq NM_001159697.1) Ccdc48 EFCC1_MOUSE ENSMUST00000159570.1 ENSMUST00000159570.2 ENSMUST00000159570.3 ENSMUST00000159570.4 ENSMUST00000159570.5 ENSMUST00000159570.6 ENSMUST00000159570.7 ENSMUST00000159570.8 MNCb-4779 NM_001159697 Q9JJF6 uc012eoo.1 uc012eoo.2 uc012eoo.3 uc012eoo.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JJF6-1; Sequence=Displayed; Name=2; IsoId=Q9JJF6-2; Sequence=VSP_039450; molecular_function calcium ion binding cytosol biological_process uc012eoo.1 uc012eoo.2 uc012eoo.3 uc012eoo.4 
ENSMUST00000159584.3 Nwd2 ENSMUST00000159584.3 NACHT and WD repeat domain containing 2 (from RefSeq NM_177006.3) ENSMUST00000159584.1 ENSMUST00000159584.2 Kiaa1239 NM_177006 NWD2_MOUSE Q3UVW7 Q6P5U7 Q8CHA7 uc008xmf.1 uc008xmf.2 uc008xmf.3 uc008xmf.4 uc008xmf.5 Sequence=BAC41474.1; Type=Erroneous initiation; Evidence=; cellular_component ribosomal large subunit biogenesis unfolded protein binding uc008xmf.1 uc008xmf.2 uc008xmf.3 uc008xmf.4 uc008xmf.5 
ENSMUST00000159592.8 Ssh1 ENSMUST00000159592.8 slingshot protein phosphatase 1, transcript variant 1 (from RefSeq NM_198109.5) ENSMUST00000159592.1 ENSMUST00000159592.2 ENSMUST00000159592.3 ENSMUST00000159592.4 ENSMUST00000159592.5 ENSMUST00000159592.6 ENSMUST00000159592.7 Kiaa1298 NM_198109 Q3TDG3 Q69ZM4 Q76I79 Q811E5 SSH1_MOUSE Ssh1 Ssh1l uc008yyy.1 uc008yyy.2 uc008yyy.3 Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20630; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Interacts with the 14-3-3 proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity and also blocks recruitment to lamellipodia and stimulation by actin (By similarity). Interacts with actin and this stimulates phosphatase activity. Interacts with LIMK1. Cytoplasm, cytoskeleton Cleavage furrow Midbody Note=Localized to the cleavage furrow and the midbody during cytokinesis (By similarity). Also colocalizes with F-actin in the cytoplasm and the cell periphery, which may allow local control of actin dynamics at sites of cell locomotion. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q76I79-1; Sequence=Displayed; Name=2; IsoId=Q76I79-2; Sequence=VSP_016320; Expressed in brain, heart, kidney and thymus. Also expressed at lower levels in liver, skeletal muscle, small intestine and spleen. Ubiquitously expressed in the embryo at 14.5 dpc. Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-970 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase (By similarity). Tyrosine phosphatase activity has not been demonstrated for this protein to date. Belongs to the protein-tyrosine phosphatase family. Sequence=BAD32422.1; Type=Erroneous initiation; Evidence=; cell morphogenesis actin binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytoplasm cytosol cytoskeleton plasma membrane protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity actin cytoskeleton organization growth cone midbody cell leading edge positive regulation of synaptic plasticity cleavage furrow regulation of cellular protein metabolic process peptidyl-tyrosine dephosphorylation cell projection cellular response to ATP excitatory chemical synaptic transmission positive regulation of neuron death positive regulation of AMPA glutamate receptor clustering positive regulation of vascular associated smooth muscle cell migration positive regulation of excitatory postsynaptic potential uc008yyy.1 uc008yyy.2 uc008yyy.3 
ENSMUST00000159602.3 A230009B12Rik ENSMUST00000159602.3 A230009B12Rik (from geneSymbol) AK045899 ENSMUST00000159602.1 ENSMUST00000159602.2 uc033har.1 uc033har.2 uc033har.3 uc033har.1 uc033har.2 uc033har.3 
ENSMUST00000159610.8 Cacna1h ENSMUST00000159610.8 calcium channel, voltage-dependent, T type, alpha 1H subunit, transcript variant 1 (from RefSeq NM_021415.4) Cacna1h E9Q6P9 E9Q6P9_MOUSE ENSMUST00000159610.1 ENSMUST00000159610.2 ENSMUST00000159610.3 ENSMUST00000159610.4 ENSMUST00000159610.5 ENSMUST00000159610.6 ENSMUST00000159610.7 NM_021415 uc057kwr.1 uc057kwr.2 uc057kwr.3 Voltage-dependent Ca(2+) channels mediate the entry of Ca(2+) ions into excitable cells and are involved in a variety of Ca(2+)-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. The protein encoded by this gene is an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]. ion channel activity voltage-gated ion channel activity voltage-gated calcium channel activity integral component of plasma membrane voltage-gated calcium channel complex ion transport low voltage-gated calcium channel activity membrane integral component of membrane aldosterone biosynthetic process cellular response to hormone stimulus cortisol biosynthetic process cellular response to potassium ion regulation of membrane potential transmembrane transport calcium ion import calcium ion transmembrane transport scaffold protein binding inorganic cation transmembrane transport positive regulation of acrosome reaction uc057kwr.1 uc057kwr.2 uc057kwr.3 
ENSMUST00000159616.2 Lrrtm1 ENSMUST00000159616.2 leucine rich repeat transmembrane neuronal 1, transcript variant 1 (from RefSeq NM_028880.4) ENSMUST00000159616.1 LRRT1_MOUSE NM_028880 Q3UVX1 Q8K377 uc009cjt.1 uc009cjt.2 uc009cjt.3 Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level. Cell membrane ; Single-pass type I membrane protein Postsynaptic cell membrane ; Single-pass type I membrane protein Note=Accumulates extensively in the endoplasmic reticulum of transfected nonneuronal cells. Expressed predominantly in the nervous system by postmitotic neurons, but also in some non-neuronal tissues. In adult brain expression is most prominent in the forebraain, particularly in the thalamus and in the cortical areas including hippocampus, piriform and posterior cingulate. Initially detected at 9 dpc with expression present in the overlying ectoderm of the limb bud in the presumptive apical ectodermal ridge. Expression is also seen in the dorsal otic vesicle in the presumptive endolymphatic appendage. Neural expression is present in the forebrain and midbrain with a sharp boundary across the central midbrain. Expression is also seen in the hindbrain. A stripe of expression can be detected in the neural tube. At 10 and 11 dpc expression is restricted to the apical ectodermal ridge. Expression persists in the endolymphatic diverticular appendage of the otic vesicle the forebrain/midbrain and the ventricular layer of the central neural tube through these stages. Mutant animals survive in the expected Mendelian ratios, are fertile and display no overt phenotype. Brain morphology appears grossly normal, except for rare cases of anomalous ventroculomegaly. Increase in the presynaptic area occupied by SLC17A7/VGLUT1 in some strata of the hippocampal neuropil of the CA1 region. Belongs to the LRRTM family. Name=Protein Spotlight; Note=The hands to say it - Issue 91 of February 2008; URL="https://web.expasy.org/spotlight/back_issues/091"; negative regulation of receptor internalization extracellular space endoplasmic reticulum plasma membrane locomotory behavior membrane integral component of membrane cell junction axon growth cone extracellular matrix protein localization to synapse exploration behavior synapse postsynaptic membrane synapse organization positive regulation of synapse assembly excitatory synapse long-term synaptic potentiation glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of postsynaptic specialization membrane regulation of presynapse assembly uc009cjt.1 uc009cjt.2 uc009cjt.3 
ENSMUST00000159619.8 Asl ENSMUST00000159619.8 Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues (By similarity). Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L- arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway (PubMed:22081021). (from UniProt Q91YI0) AK140160 ARLY_MOUSE ENSMUST00000159619.1 ENSMUST00000159619.2 ENSMUST00000159619.3 ENSMUST00000159619.4 ENSMUST00000159619.5 ENSMUST00000159619.6 ENSMUST00000159619.7 Q3UFA2 Q91YI0 uc291aet.1 uc291aet.2 Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues (By similarity). Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L- arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway (PubMed:22081021). Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine; Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682, ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24021; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:24022; Evidence=; Enzyme activity is regulated by acetylation. Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. Nitrogen metabolism; urea cycle; L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1. Homotetramer (By similarity). Forms tissue-specific complexes with ASS1, SLC7A1, HSP90AA1 and nitric oxide synthase NOS1, NOS2 or NOS3; the complex maintenance is independent of ASL catalytic function (PubMed:22081021). Expressed in lung and brain (at protein level). Acetylation modifies enzyme activity in response to alterations of extracellular nutrient availability. Acetylation increased with trichostin A (TSA) or with nicotinamide (NAM). Glucose increases acetylation by about a factor of 3 with decreasing enzyme activity. Acetylation on Lys-288 is decreased on the addition of extra amino acids resulting in activation of enzyme activity. Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. urea cycle argininosuccinate metabolic process liver development catalytic activity argininosuccinate lyase activity nucleus cytoplasm mitochondrial outer membrane endoplasmic reticulum cellular amino acid metabolic process arginine biosynthetic process locomotory behavior cellular amino acid biosynthetic process post-embryonic development lyase activity ammonia assimilation cycle arginine biosynthetic process via ornithine identical protein binding neuronal cell body perikaryon perinuclear region of cytoplasm cell body fiber uc291aet.1 uc291aet.2 
ENSMUST00000159627.2 Gm16582 ENSMUST00000159627.2 predicted gene 16582 (from RefSeq NR_151618.1) ENSMUST00000159627.1 NR_151618 uc287jgx.1 uc287jgx.2 uc287jgx.1 uc287jgx.2 
ENSMUST00000159679.8 Ntmt2 ENSMUST00000159679.8 N-terminal Xaa-Pro-Lys N-methyltransferase 2 (from RefSeq NM_001143956.1) B2RXM4 ENSMUST00000159679.1 ENSMUST00000159679.2 ENSMUST00000159679.3 ENSMUST00000159679.4 ENSMUST00000159679.5 ENSMUST00000159679.6 ENSMUST00000159679.7 Mettl11b NM_001143956 NTM1B_MOUSE uc011wus.1 uc011wus.2 uc011wus.3 Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro). May activate NTMT1 by priming its substrates for trimethylation. Reaction=N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L- methionine = H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl- [protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54096, Rhea:RHEA-COMP:13785, Rhea:RHEA-COMP:13786, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138057, ChEBI:CHEBI:138058; EC=2.1.1.299; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54097; Evidence=; Reaction=N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L- methionine = H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl- [protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54100, Rhea:RHEA-COMP:13787, Rhea:RHEA-COMP:13788, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138059, ChEBI:CHEBI:138060; EC=2.1.1.299; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54101; Evidence=; Reaction=N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L- methionine = H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl- [protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54104, Rhea:RHEA-COMP:13789, Rhea:RHEA-COMP:13790, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138061, ChEBI:CHEBI:138062; EC=2.1.1.299; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54105; Evidence=; Nucleus Belongs to the methyltransferase superfamily. NTM1 family. nucleus cytoplasm N-terminal protein amino acid methylation methyltransferase activity transferase activity methylation N-terminal protein N-methyltransferase activity uc011wus.1 uc011wus.2 uc011wus.3 
ENSMUST00000159680.9 Tnik ENSMUST00000159680.9 TRAF2 and NCK interacting kinase, transcript variant 4 (from RefSeq NM_001163009.1) B9EKN8 B9EKN8_MOUSE ENSMUST00000159680.1 ENSMUST00000159680.2 ENSMUST00000159680.3 ENSMUST00000159680.4 ENSMUST00000159680.5 ENSMUST00000159680.6 ENSMUST00000159680.7 ENSMUST00000159680.8 NM_001163009 Tnik uc012coc.1 uc012coc.2 uc012coc.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. protein kinase activity ATP binding protein phosphorylation kinase activity phosphorylation uc012coc.1 uc012coc.2 uc012coc.3 
ENSMUST00000159692.8 Ermp1 ENSMUST00000159692.8 endoplasmic reticulum metallopeptidase 1, transcript variant 2 (from RefSeq NM_001362131.1) B2RXD6 D19Wsu12e ENSMUST00000159692.1 ENSMUST00000159692.2 ENSMUST00000159692.3 ENSMUST00000159692.4 ENSMUST00000159692.5 ENSMUST00000159692.6 ENSMUST00000159692.7 ERMP1_MOUSE Ermp1 Fxna Kiaa1815 NM_001362131 Q3UVK0 Q6ZPH9 Q8BIW0 Q8BYX7 uc008hdu.1 uc008hdu.2 uc008hdu.3 Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UVK0-1; Sequence=Displayed; Name=2; IsoId=Q3UVK0-2; Sequence=VSP_021393, VSP_021394; Belongs to the peptidase M28 family. Sequence=BAC29784.1; Type=Erroneous initiation; Evidence=; Sequence=BAC38286.1; Type=Erroneous initiation; Evidence=; ovarian follicle development molecular_function endoplasmic reticulum endoplasmic reticulum membrane proteolysis peptidase activity metallopeptidase activity membrane integral component of membrane hydrolase activity metal ion binding uc008hdu.1 uc008hdu.2 uc008hdu.3 
ENSMUST00000159701.3 Gm15852 ENSMUST00000159701.3 Gm15852 (from geneSymbol) AK018906 ENSMUST00000159701.1 ENSMUST00000159701.2 uc287npa.1 uc287npa.2 uc287npa.3 uc287npa.1 uc287npa.2 uc287npa.3 
ENSMUST00000159707.2 Gm10176 ENSMUST00000159707.2 Gm10176 (from geneSymbol) AK029767 ENSMUST00000159707.1 uc287nfi.1 uc287nfi.2 uc287nfi.1 uc287nfi.2 
ENSMUST00000159715.8 Galnt6 ENSMUST00000159715.8 polypeptide N-acetylgalactosaminyltransferase 6, transcript variant 2 (from RefSeq NM_172451.3) ENSMUST00000159715.1 ENSMUST00000159715.2 ENSMUST00000159715.3 ENSMUST00000159715.4 ENSMUST00000159715.5 ENSMUST00000159715.6 ENSMUST00000159715.7 GALT6_MOUSE NM_172451 Q0VE84 Q3TWF0 Q8C7U7 Q8CED2 Q9QZ16 uc007xsa.1 uc007xsa.2 uc007xsa.3 uc007xsa.4 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides (By similarity). Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Evidence=; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Sequence=CAB55352.1; Type=Frameshift; Evidence=; Name=Functional Glycomics Gateway - GTase; Note=Polypeptide N-acetylgalactosaminyltransferase 6; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_515"; Golgi membrane polypeptide N-acetylgalactosaminyltransferase activity Golgi apparatus protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups carbohydrate binding metal ion binding perinuclear region of cytoplasm uc007xsa.1 uc007xsa.2 uc007xsa.3 uc007xsa.4 
ENSMUST00000159738.2 Nckap5los ENSMUST00000159738.2 Nckap5los (from geneSymbol) AK014921 ENSMUST00000159738.1 uc289bgd.1 uc289bgd.2 uc289bgd.1 uc289bgd.2 
ENSMUST00000159759.3 AI837181 ENSMUST00000159759.3 expressed sequence AI837181, transcript variant 1 (from RefSeq NM_134149.2) Bles03 CK068_MOUSE E9QNR6 ENSMUST00000159759.1 ENSMUST00000159759.2 NM_134149 Q6LCE3 Q8VD62 uc008gda.1 uc008gda.2 uc008gda.3 uc008gda.4 uc008gda.5 uc008gda.6 Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q8VD62-2; Sequence=Displayed; Name=1; IsoId=Q8VD62-1; Sequence=VSP_059973, VSP_059974; Belongs to the UPF0696 family. Sequence=AAH24516.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence=; cellular_component biological_process uc008gda.1 uc008gda.2 uc008gda.3 uc008gda.4 uc008gda.5 uc008gda.6 
ENSMUST00000159767.3 Gm6507 ENSMUST00000159767.3 Gm6507 (from geneSymbol) ENSMUST00000159767.1 ENSMUST00000159767.2 uc291gwz.1 uc291gwz.2 uc291gwz.3 uc291gwz.1 uc291gwz.2 uc291gwz.3 
ENSMUST00000159816.8 Filip1l ENSMUST00000159816.8 filamin A interacting protein 1-like, transcript variant 1 (from RefSeq NM_001040397.5) E0CYH7 E0CYH7_MOUSE ENSMUST00000159816.1 ENSMUST00000159816.2 ENSMUST00000159816.3 ENSMUST00000159816.4 ENSMUST00000159816.5 ENSMUST00000159816.6 ENSMUST00000159816.7 Filip1l NM_001040397 uc012agu.1 uc012agu.2 uc012agu.3 uc012agu.1 uc012agu.2 uc012agu.3 
ENSMUST00000159855.8 Mycbp2 ENSMUST00000159855.8 MYC binding protein 2, E3 ubiquitin protein ligase (from RefSeq NM_207215.2) E9PUJ6 ENSMUST00000159855.1 ENSMUST00000159855.2 ENSMUST00000159855.3 ENSMUST00000159855.4 ENSMUST00000159855.5 ENSMUST00000159855.6 ENSMUST00000159855.7 MYCB2_MOUSE Mycbp2 NM_207215 Pam Phr1 Q6PCM8 Q7TPH6 uc007uwl.1 uc007uwl.2 Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (By similarity). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (By similarity). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (PubMed:14729956, PubMed:17901218, PubMed:18031680). Required for the formation of major central nervous system axon tracts (PubMed:17901218, PubMed:18031680). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK (PubMed:18031680). Required for proper localization of retinogeniculate projections but not for eye-specific segregation (PubMed:19371781, PubMed:21324225). Regulates axon guidance in the olfactory system (PubMed:23525682). Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2 (PubMed:23665224). Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown (By similarity). Regulates the internalization of TRPV1 in peripheral sensory neurons (PubMed:21098484). May mediate ubiquitination and subsequent proteasomal degradation of TSC2/tuberin (By similarity). Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia (PubMed:26304119). May function as a facilitator or regulator of transcriptional activation by MYC (By similarity). Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine.; EC=2.3.2.33; Evidence=; Protein modification; protein ubiquitination. Interacts with MYC (By similarity). Interacts with TSC2 (tuberin) when TSC2 is in complex with TSC1 (hamartin) (By similarity). Interacts with FBXO45 (PubMed:19398581). Interacts with RAE1 (By similarity). Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (PubMed:12522145). Interacts with (sumoylated) RANGAP1; interaction with sumoylated RANGAP1 inhibits E3 ubiquitin-protein ligase activity and promotes MYCBP2 translocation to the nucleus (PubMed:26304119). Interacts with RAN (PubMed:26304119). Interacts with ATP13A2; the interaction inhibits the ubiquitination of TSC2 by MYCBP2 (By similarity). Interacts with USP11 (By similarity). Q7TPH6; Q63633: Slc12a5; Xeno; NbExp=4; IntAct=EBI-1811542, EBI-1811510; Nucleus Cell projection, axon Cytoplasm, cytoskeleton Note=Localizes to axon shafts and associates with microtubule cytoskeleton (PubMed:18031680). Translocates to the nucleus following interaction with sumoylated RANGAP1 (PubMed:26304119). Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q7TPH6-1; Sequence=Displayed; Name=2 ; IsoId=Q7TPH6-2; Sequence=VSP_014184; Expression is mostly restricted to the nervous system, including expression in motor and sensory axons (PubMed:18031680). During postnatal development, expression is particularly strong in the cerebellum, hippocampus and retina (PubMed:14729956). Lower levels of expression are observed throughout the cerebral cortex (PubMed:14729956). Dynamically expressed in embryonic nervous system from 8.5 dpc through 18.5 dpc (PubMed:14729956, PubMed:18031680). At 10.5 dpc, shortly after the birth of the first motor neurons, highly expressed in the developing motor columns, dorsal root ganglion and newly formed neurons within the dorsal neural tube (PubMed:18031680). As embryos develop to 11.5 dpc, expression levels increase in the dorsal root ganglion and expression in the spinal cord expandes as the number of postmitotic neurons increase (PubMed:18031680). By 12.5 dpc expression is widespread within the spinal cord (PubMed:18031680). The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners. The tandem cysteine domain region confers threonine specificity and contains the two essential catalytic cysteine residues that relay ubiquitin. It binds four zinc ions in a C5HC7HC2 configuration. Autoubiquitinated. Lethality caused by defects in neuromuscular development (PubMed:17901218). Mice die at birth without taking a breath: phrenic nerves are markedly narrower and contain fewer axons than controls (PubMed:17901218). Mice display incomplete innervation of the diaphragm by the phrenic nerve (PubMed:14729956, PubMed:17901218). Intercostal muscles are completely innervated, but show dysmorphic nerve terminals (PubMed:14729956, PubMed:17901218). Sensory neuron terminals in the diaphragm are abnormal and neuromuscular junctions show excessive sprouting of nerve terminals, consistent with inadequate presynaptic stimulation of the muscle (PubMed:14729956). Embryos display motor axon misprojections and stalling: motor axons are error- prone and wander inefficiently at choice points within embryos (PubMed:18031680). Conditional knockout mice lacking Mycbp2 in the retina, exhibit no gross retinal developmental defects; mutants retain normal retinal lamination, monocular segregation and spontaneous retinal wave activity, but mutant retinal ganglion cells exhibit ipsilateral projection to an improper region of the dorsal lateral geniculate nucleus (dLGN) (PubMed:19371781, PubMed:21324225). Conditional knockout mice lacking Mycbp2 in peripheral sensory neurons display prolonged thermal hyperalgesia: defects are caused by constitutive activation of MAP kinase p38 (Mapk11, Mapk12, Mapk13 and/or Mapk14), leading to inhibit internalization of Trpv1 (PubMed:21098484). Belongs to the RING-Cys relay (RCR) family. guanyl-nucleotide exchange factor activity protein binding nucleus cytoplasm cytoskeleton motor neuron axon guidance zinc ion binding Ran GTPase binding microtubule cytoskeleton protein ubiquitination transferase activity branchiomotor neuron axon guidance central nervous system projection neuron axonogenesis axon positive regulation of protein ubiquitination regulation of protein localization circadian regulation of gene expression negative regulation of protein catabolic process protein homodimerization activity cell projection intracellular membrane-bounded organelle metal ion binding rhythmic process cell morphogenesis involved in neuron differentiation neuromuscular process regulation of cytoskeleton organization ubiquitin protein ligase activity regulation of axon guidance uc007uwl.1 uc007uwl.2 
ENSMUST00000159861.9 Pappa2 ENSMUST00000159861.9 pappalysin 2 (from RefSeq NM_001085376.3) E9PZ87 E9PZ87_MOUSE ENSMUST00000159861.1 ENSMUST00000159861.2 ENSMUST00000159861.3 ENSMUST00000159861.4 ENSMUST00000159861.5 ENSMUST00000159861.6 ENSMUST00000159861.7 ENSMUST00000159861.8 NM_001085376 Pappa2 uc007ddv.1 uc007ddv.2 uc007ddv.3 Belongs to the peptidase M43B family. Lacks conserved residue(s) required for the propagation of feature annotation. metalloendopeptidase activity cytosol proteolysis metallopeptidase activity zinc ion binding response to salt stress apical plasma membrane bone morphogenesis uc007ddv.1 uc007ddv.2 uc007ddv.3 
ENSMUST00000159874.3 Gm15524 ENSMUST00000159874.3 Gm15524 (from geneSymbol) ENSMUST00000159874.1 ENSMUST00000159874.2 uc288gmw.1 uc288gmw.2 uc288gmw.1 uc288gmw.2 
ENSMUST00000159877.3 Sh2d6 ENSMUST00000159877.3 Sh2d6 (from geneSymbol) BC100525 E0CYY5 E0CYY5_MOUSE E2QRQ0 ENSMUST00000159877.1 ENSMUST00000159877.2 Sh2d6 uc291fuw.1 uc291fuw.2 uc291fuw.1 uc291fuw.2 
ENSMUST00000159879.2 Ro60 ENSMUST00000159879.2 Ro60, Y RNA binding protein (from RefSeq NM_013835.2) ENSMUST00000159879.1 NM_013835 Q3TJ75 Q3TJ75_MOUSE Ro60 Trove2 uc007cxd.1 uc007cxd.2 uc007cxd.3 uc007cxd.4 Cytoplasm Belongs to the Ro 60 kDa family. RNA binding nucleoplasm cytosol regulation of gene expression cellular response to interferon-alpha ribonucleoprotein complex uc007cxd.1 uc007cxd.2 uc007cxd.3 uc007cxd.4 
ENSMUST00000159897.2 Gm15995 ENSMUST00000159897.2 Gm15995 (from geneSymbol) ENSMUST00000159897.1 uc288jlh.1 uc288jlh.2 uc288jlh.1 uc288jlh.2 
ENSMUST00000159899.8 Pigk ENSMUST00000159899.8 phosphatidylinositol glycan anchor biosynthesis, class K, transcript variant 1 (from RefSeq NM_025662.5) ENSMUST00000159899.1 ENSMUST00000159899.2 ENSMUST00000159899.3 ENSMUST00000159899.4 ENSMUST00000159899.5 ENSMUST00000159899.6 ENSMUST00000159899.7 GPI8_MOUSE NM_025662 Q8BH63 Q9CXY9 uc012czo.1 uc012czo.2 uc012czo.3 uc012czo.4 Component of the GPI transamidase complex, necessary for transfer of GPI to proteins (By similarity). Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Forms a complex with PIGT, PIGS, PIGU and GAA1. Endoplasmic reticulum membrane ; Single-pass type I membrane protein The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity. Belongs to the peptidase C13 family. GPI-anchor transamidase activity endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process proteolysis peptidase activity cysteine-type peptidase activity membrane integral component of membrane attachment of GPI anchor to protein hydrolase activity protein localization to cell surface GPI-anchor transamidase complex uc012czo.1 uc012czo.2 uc012czo.3 uc012czo.4 
ENSMUST00000159916.5 Prrt2 ENSMUST00000159916.5 proline-rich transmembrane protein 2 (from RefSeq NM_001102563.1) E9PUL5 ENSMUST00000159916.1 ENSMUST00000159916.2 ENSMUST00000159916.3 ENSMUST00000159916.4 NM_001102563 PRRT2_MOUSE uc009jty.1 uc009jty.2 uc009jty.3 As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing (PubMed:27052163). In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation (PubMed:29056747). Component of the outer core of AMPAR complex (PubMed:22632720, PubMed:25915028). AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (PubMed:22632720). Interacts with intersectin 1/ITSN1 (PubMed:26797119). Interacts with SNARE complex components, including SNAP25, STX1A, SYT1 and SYT2; this interaction may inhibit SNARE complex formation (PubMed:22832103, PubMed:27052163, PubMed:29056747). Cell membrane ingle-pass membrane protein Presynaptic cell membrane ; Single-pass membrane protein Synapse ll projection, axon Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Postsynaptic density membrane Cell projection, dendritic spine Neuron-specific expression throughout the brain, with the highest levels in the cerebellum, basal ganglia, hippocampus, substantia nigra, and neocortex (at protein level) (PubMed:22101681, PubMed:22243967, PubMed:22832103, PubMed:22632720, PubMed:25915028, PubMed:27052163, PubMed:27172900, PubMed:28007585, PubMed:29056747). Highly expressed also in spinal cord (at protein level) (PubMed:22101681, PubMed:22832103). Detected at very low levels in the heart, lung, kidney and skin (PubMed:22101681). At the mRNA level, expressed at low levels in the developing brain before 16 dpc. Expression markedly increases during early postnatal stages with a peak at P14. At this stage, expressed throughout the brain, with high levels in the cerebral cortex (cortical layers), hippocampus and cerebellum (granule cells and Purkinje cell layers). Progressively declines to relatively low levels in adulthood. At the protein level, first detected at very low levels at 17.5 dpc. Expression increases at early postnatal stages in the cerebral cortex, hippocampus and cerebellum. Expression increases to reach a plateau around P14, a period of intense synapse formation and rearrangement, and starts to slightly decrease around P90 (at protein level) (PubMed:27052163, PubMed:29056747). Mutant mice are normal at birth, but display paroxysmal movements at the onset of locomotion that persist in the adulthood. Adult animals present abnormal motor behaviors characterized by wild running and jumping in response to audiogenic stimuli that are ineffective in wild-type mice and an increased sensitivity to the convulsive effects of pentylentetrazol. Although the overall brain structure is not affected by the knockout, the thickness of the neocortex in young adult is significantly reduced in medial and caudal regions compared to their wild-type littermates. No significant differences are observed in the thickness of the CA1, CA3 and DG regions of the hippocampus, as well as for the molecular and granule layers of the cerebellum (PubMed:28007585). Mice with a conditional knockout in the central nervous system develop normally, but showed poor performance in motor coordination functions (PubMed:29056747). Belongs to the CD225/Dispanin family. protein binding plasma membrane synaptic vesicle postsynaptic density membrane integral component of membrane syntaxin-1 binding SH3 domain binding cell junction axon synaptic vesicle membrane cytoplasmic vesicle synaptic vesicle fusion to presynaptic active zone membrane vesicle negative regulation of SNARE complex assembly presynaptic membrane cell projection neuron projection dendritic spine axon terminus synapse postsynaptic membrane neuromuscular process controlling posture presynapse glutamatergic synapse integral component of presynaptic membrane calcium-dependent activation of synaptic vesicle fusion negative regulation of short-term synaptic potentiation uc009jty.1 uc009jty.2 uc009jty.3 
ENSMUST00000159917.8 Pcmt1 ENSMUST00000159917.8 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1, transcript variant 2 (from RefSeq NM_008786.6) ENSMUST00000159917.1 ENSMUST00000159917.2 ENSMUST00000159917.3 ENSMUST00000159917.4 ENSMUST00000159917.5 ENSMUST00000159917.6 ENSMUST00000159917.7 NM_008786 Pcmt1 Q545L9 Q545L9_MOUSE uc007ehx.1 uc007ehx.2 uc007ehx.3 uc007ehx.4 Reaction=[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:12705, Rhea:RHEA-COMP:12143, Rhea:RHEA- COMP:12144, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90596, ChEBI:CHEBI:90598; EC=2.1.1.77; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12706; Evidence=; Monomer. Cytoplasm, cytosol Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family. protein-L-isoaspartate (D-aspartate) O-methyltransferase activity cellular protein modification process protein methylation methyltransferase activity transferase activity methylation uc007ehx.1 uc007ehx.2 uc007ehx.3 uc007ehx.4 
ENSMUST00000159939.8 Phf21b ENSMUST00000159939.8 PHD finger protein 21B, transcript variant 2 (from RefSeq NR_030731.1) ENSMUST00000159939.1 ENSMUST00000159939.2 ENSMUST00000159939.3 ENSMUST00000159939.4 ENSMUST00000159939.5 ENSMUST00000159939.6 ENSMUST00000159939.7 NR_030731 PF21B_MOUSE Q8C966 uc007xco.1 uc007xco.2 uc007xco.3 uc007xco.4 metal ion binding uc007xco.1 uc007xco.2 uc007xco.3 uc007xco.4 
ENSMUST00000159945.8 Slc9c1 ENSMUST00000159945.8 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 (from RefSeq NM_198106.4) E0CX34 ENSMUST00000159945.1 ENSMUST00000159945.2 ENSMUST00000159945.3 ENSMUST00000159945.4 ENSMUST00000159945.5 ENSMUST00000159945.6 ENSMUST00000159945.7 Gm610 NM_198106 Q6UJY2 Q7M6Y7 SL9C1_MOUSE Slc9a10 uc007ziq.1 uc007ziq.2 uc007ziq.3 uc007ziq.4 Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC). Interacts with soluble adenylyl cyclase (sAC). Q6UJY2; Q8C0T9: Adcy10; NbExp=2; IntAct=EBI-15639080, EBI-15639026; Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein Testis-specific. Specifically present in the principal piece of sperm tail (at protein level). The ion transport-like region is related to the membrane segments of voltage-gated ion channels. Its function is unknown. Mice are normal but males are sterile. Male sterility is due to defects in sperm motility inability to fertilize intact eggs. Moreover, spermatozoa fail to develop the cAMP-dependent protein tyrosine phosphorylation that coincides with the functional maturation occurring upon incubation in capacitating conditions in vitro. cAMP analogs almost completely rescue the motility and infertility phenotypes. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Sequence=AAQ88278.1; Type=Frameshift; Evidence=; Sequence=DAA01464.1; Type=Erroneous gene model prediction; Evidence=; protein binding plasma membrane cilium ion transport cation transport sodium ion transport multicellular organism development spermatogenesis antiporter activity solute:proton antiporter activity sodium:proton antiporter activity potassium:proton antiporter activity membrane integral component of membrane cell differentiation flagellated sperm motility motile cilium cell projection regulation of intracellular pH transmembrane transport ciliary membrane potassium ion transmembrane transport anion transmembrane transport sodium ion import across plasma membrane hydrogen ion transmembrane transport uc007ziq.1 uc007ziq.2 uc007ziq.3 uc007ziq.4 
ENSMUST00000159963.8 Chit1 ENSMUST00000159963.8 chitinase 1, transcript variant 3 (from RefSeq NM_027979.2) CHIT1_MOUSE ENSMUST00000159963.1 ENSMUST00000159963.2 ENSMUST00000159963.3 ENSMUST00000159963.4 ENSMUST00000159963.5 ENSMUST00000159963.6 ENSMUST00000159963.7 NM_027979 Q6QJD2 Q9D7Q1 uc007crf.1 uc007crf.2 uc007crf.3 Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens (By similarity). Reaction=Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.; EC=3.2.1.14; Monomer. Secreted Lysosome Note=A small proportion is lysosomal. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D7Q1-1; Sequence=Displayed; Name=2; IsoId=Q9D7Q1-2; Sequence=VSP_020143, VSP_020144; Highly expressed in tongue, stomach, kidney, brain, skin, testis, and bone marrow. Low level of expression was found in lung, heart, spleen, small intestine, and liver. Not detectable in pancreas, salivary gland, large intestine, uterus, or peripheral blood mononuclear cells (PBMC). Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. polysaccharide catabolic process hydrolase activity, hydrolyzing O-glycosyl compounds chitinase activity extracellular region extracellular space cytoplasm lysosome carbohydrate metabolic process chitin metabolic process chitin catabolic process chitin binding metabolic process endochitinase activity hydrolase activity hydrolase activity, acting on glycosyl bonds uc007crf.1 uc007crf.2 uc007crf.3 
ENSMUST00000159971.2 Gm16555 ENSMUST00000159971.2 predicted gene 16555 (from RefSeq NR_168028.1) ENSMUST00000159971.1 NR_168028 uc289luo.1 uc289luo.2 uc289luo.1 uc289luo.2 
ENSMUST00000159973.3 Speer4e1 ENSMUST00000159973.3 spermatogenesis associated glutamate (E)-rich protein 4E1 (from RefSeq NM_001122661.1) ENSMUST00000159973.1 ENSMUST00000159973.2 K7N6S8 K7N6S8_MOUSE NM_001122661 Speer4e uc012dsi.1 uc012dsi.2 uc012dsi.3 molecular_function cellular_component biological_process uc012dsi.1 uc012dsi.2 uc012dsi.3 
ENSMUST00000159983.8 Lgals12 ENSMUST00000159983.8 lectin, galactose binding, soluble 12, transcript variant 2 (from RefSeq NM_001356574.2) ENSMUST00000159983.1 ENSMUST00000159983.2 ENSMUST00000159983.3 ENSMUST00000159983.4 ENSMUST00000159983.5 ENSMUST00000159983.6 ENSMUST00000159983.7 LEG12_MOUSE NM_001356574 Q3UW90 Q8CCA4 Q8K2L7 Q91VD1 Q9JKX2 uc008gll.1 uc008gll.2 uc008gll.3 Binds lactose. May participate in the apoptosis of adipocytes. Nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VD1-1; Sequence=Displayed; Name=2; IsoId=Q91VD1-2; Sequence=VSP_010321; Contains two homologous but distinct carbohydrate-binding domains. Name=Functional Glycomics Gateway - Glycan Binding; Note=Galectin-12; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Stlect_289"; nucleus cytoplasm mitochondrion apoptotic process carbohydrate binding lactose binding regulation of fat cell differentiation regulation of lipid catabolic process intrinsic apoptotic signaling pathway uc008gll.1 uc008gll.2 uc008gll.3 
ENSMUST00000159985.2 Hephl1 ENSMUST00000159985.2 hephaestin-like 1 (from RefSeq NM_001164797.1) ENSMUST00000159985.1 Gm509 HPHL1_MOUSE NM_001164797 Q3V1H3 uc009ofj.1 uc009ofj.2 uc009ofj.3 Is a copper-binding glycoprotein with ferroxidase activity. It oxidizes Fe(2+) to Fe(3+) without releasing radical oxygen species. May be involved in the regulation of intracellular iron content. Reaction=4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O; Xref=Rhea:RHEA:11148, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.16.3.1; Evidence=; Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Note=Binds 6 Cu cations per monomer. ; Membrane ; Single-pass type I membrane protein Note=Defects in HEPHL1 are the cause of the curly whiskers phenotype (cw). Curly whiskers mice carry a recessive mutation that alters splicing and causes omission of exon 11 from the mature transcript. The cw phenotype is characterized by kinky, brittle vibrissae. HEPHL1 knockdown mice exhibit short and curled whiskers. Belongs to the multicopper oxidase family. Sequence=BAE21178.1; Type=Erroneous initiation; Evidence=; ferroxidase activity copper ion binding plasma membrane ion transport copper ion transport iron ion transport membrane integral component of membrane oxidoreductase activity metal ion binding iron ion homeostasis oxidation-reduction process uc009ofj.1 uc009ofj.2 uc009ofj.3 
ENSMUST00000159989.2 Clca3b ENSMUST00000159989.2 chloride channel accessory 3B (from RefSeq NM_139148.2) Clca3b Clca4 E9PUL3 E9PUL3_MOUSE ENSMUST00000159989.1 NM_139148 uc012cyz.1 uc012cyz.2 uc012cyz.3 uc012cyz.4 uc012cyz.5 Belongs to the CLCR family. intracellular calcium activated chloride channel activity integral component of plasma membrane chloride transport ion transmembrane transport uc012cyz.1 uc012cyz.2 uc012cyz.3 uc012cyz.4 uc012cyz.5 
ENSMUST00000159993.8 Col22a1 ENSMUST00000159993.8 collagen, type XXII, alpha 1 (from RefSeq NM_027174.1) Col22a1 E9Q7P1 E9Q7P1_MOUSE ENSMUST00000159993.1 ENSMUST00000159993.2 ENSMUST00000159993.3 ENSMUST00000159993.4 ENSMUST00000159993.5 ENSMUST00000159993.6 ENSMUST00000159993.7 NM_027174 uc007wbj.1 uc007wbj.2 uc007wbj.3 uc007wbj.4 extracellular matrix structural constituent extracellular space extracellular matrix structural constituent conferring tensile strength extracellular matrix organization extracellular matrix uc007wbj.1 uc007wbj.2 uc007wbj.3 uc007wbj.4 
ENSMUST00000160013.8 Gng2 ENSMUST00000160013.8 guanine nucleotide binding protein (G protein), gamma 2, transcript variant 1 (from RefSeq NM_010315.4) ENSMUST00000160013.1 ENSMUST00000160013.2 ENSMUST00000160013.3 ENSMUST00000160013.4 ENSMUST00000160013.5 ENSMUST00000160013.6 ENSMUST00000160013.7 GBG2_MOUSE NM_010315 P16874 P63213 Q3TYE8 Q61013 Q9TS47 uc007six.1 uc007six.2 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units, alpha, beta and gamma (By similarity). In this context, interacts with GNB2 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Adrenal gland and brain. Belongs to the G protein gamma family. GTPase activity heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway cell proliferation membrane G-protein beta/gamma-subunit complex G-protein beta-subunit binding uc007six.1 uc007six.2 
ENSMUST00000160019.8 Stac3 ENSMUST00000160019.8 SH3 and cysteine rich domain 3, transcript variant 2 (from RefSeq NM_001359751.1) ENSMUST00000160019.1 ENSMUST00000160019.2 ENSMUST00000160019.3 ENSMUST00000160019.4 ENSMUST00000160019.5 ENSMUST00000160019.6 ENSMUST00000160019.7 NM_001359751 Q8BZ71 STAC3_MOUSE uc007hjr.1 uc007hjr.2 uc007hjr.3 Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization (PubMed:23818578, PubMed:27621462, PubMed:29467163). Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction (PubMed:23818578). Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane (PubMed:27621462). Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (PubMed:25548159, PubMed:27621462, PubMed:29467163). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:25548159, PubMed:29363593). Interacts (via SH3 domains) with the calcium channels CACNA1S and CACNA1C (PubMed:28112192, PubMed:29467163, PubMed:29363593). Component of a calcium channel complex with CACNA1S and CACNB1 (PubMed:28112192). Component of a calcium channel complex with CACNA1C and CACNB1 (PubMed:28112192). Cytoplasm ll membrane, sarcolemma eripheral membrane protein ytoplasmic side ll membrane, sarcolemma, T-tubule te=Co-localizes with CACNA1S and CACNA1C on T-tubules. Dected in skeletal muscle, including soleus, extensor digitorum longus, tibialis anterior, quadriceps and gastrocnemius. Detected in tongue. Detected in somites and limb buds at 9.5 and 13 dpc, in embryonic limb muscle and tongue (PubMed:23626854, PubMed:23818578). Detected in tongue and diaphragm at 14.5 dpc (PubMed:23818578). Complete perinatal lethality, due to paralysis and inability to breathe (PubMed:23626854, PubMed:23818578). Embryos have a curved body with abnormal curvature of the vertebral spine and drooping forelimbs (PubMed:23626854, PubMed:23818578). They display multiple skeletal abnormalities involving ribs, sternum and costal cartilage, and strongly reduced formation of bone ridges at major muscle attachment sites (PubMed:23818578). They weigh about 15% less than wild-type at 18.5 dpc (PubMed:23626854). They do not move or respond to touch, but have a beating heart when dissected out of the uterus (PubMed:23626854). Their myofibers have altered morphology with centrally located nuclei, unlike wild-type, where the nuclei are located in the periphery of the myofibers (PubMed:23626854, PubMed:23818578). Sarcomeres have streaming Z-lines (PubMed:23626854). The diaphragm does not contract in response to membrane depolarization or electric stimulation (PubMed:23818578). Myotubes from mutant mice lack voltage-induced calcium release from the sarcoplasmic reticulum (PubMed:23818578). skeletal muscle contraction nucleoplasm cytoplasm cytosol plasma membrane voltage-gated calcium channel complex neuromuscular synaptic transmission membrane T-tubule extrinsic component of cytoplasmic side of plasma membrane intracellular signal transduction sarcolemma identical protein binding metal ion binding skeletal muscle fiber development positive regulation of voltage-gated calcium channel activity positive regulation of protein localization to plasma membrane uc007hjr.1 uc007hjr.2 uc007hjr.3 
ENSMUST00000160027.8 Psma3 ENSMUST00000160027.8 proteasome subunit alpha 3, transcript variant 1 (from RefSeq NM_011184.5) ENSMUST00000160027.1 ENSMUST00000160027.2 ENSMUST00000160027.3 ENSMUST00000160027.4 ENSMUST00000160027.5 ENSMUST00000160027.6 ENSMUST00000160027.7 NM_011184 Psma3 Q58EV4 Q58EV4_MOUSE uc007ntz.1 uc007ntz.2 uc007ntz.3 uc007ntz.4 uc007ntz.5 The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. Cytoplasm Nucleus Belongs to the peptidase T1A family. proteasome complex endopeptidase activity threonine-type endopeptidase activity nucleus cytoplasm proteasome core complex proteolysis ubiquitin-dependent protein catabolic process peptidase activity hydrolase activity proteasome core complex, alpha-subunit complex ubiquitin protein ligase binding synapse proteolysis involved in cellular protein catabolic process regulation of endopeptidase activity uc007ntz.1 uc007ntz.2 uc007ntz.3 uc007ntz.4 uc007ntz.5 
ENSMUST00000160030.2 Gm16043 ENSMUST00000160030.2 Gm16043 (from geneSymbol) ENSMUST00000160030.1 uc291cml.1 uc291cml.2 uc291cml.1 uc291cml.2 
ENSMUST00000160052.2 ENSMUSG00000121655 ENSMUST00000160052.2 ENSMUSG00000121655 (from geneSymbol) BC019129 ENSMUST00000160052.1 uc292fui.1 uc292fui.2 uc292fui.1 uc292fui.2 
ENSMUST00000160058.8 Gm52950 ENSMUST00000160058.8 Gm52950 (from geneSymbol) AK156902 ENSMUST00000160058.1 ENSMUST00000160058.2 ENSMUST00000160058.3 ENSMUST00000160058.4 ENSMUST00000160058.5 ENSMUST00000160058.6 ENSMUST00000160058.7 uc287jwh.1 uc287jwh.2 uc287jwh.1 uc287jwh.2 
ENSMUST00000160080.3 Gm16559 ENSMUST00000160080.3 Gm16559 (from geneSymbol) AK082149 ENSMUST00000160080.1 ENSMUST00000160080.2 uc290kbq.1 uc290kbq.2 uc290kbq.3 uc290kbq.1 uc290kbq.2 uc290kbq.3 
ENSMUST00000160088.3 Gm16227 ENSMUST00000160088.3 Gm16227 (from geneSymbol) ENSMUST00000160088.1 ENSMUST00000160088.2 uc290xjw.1 uc290xjw.2 uc290xjw.3 uc290xjw.1 uc290xjw.2 uc290xjw.3 
ENSMUST00000160110.3 Phtf1os ENSMUST00000160110.3 putative homeodomain transcription factor 1, opposite strand (from RefSeq NR_030676.1) ENSMUST00000160110.1 ENSMUST00000160110.2 NR_030676 uc008qty.1 uc008qty.2 uc008qty.3 uc008qty.4 uc008qty.5 uc008qty.1 uc008qty.2 uc008qty.3 uc008qty.4 uc008qty.5 
ENSMUST00000160116.8 Impg2 ENSMUST00000160116.8 Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin. (from UniProt Q80XH2) AY174061 ENSMUST00000160116.1 ENSMUST00000160116.2 ENSMUST00000160116.3 ENSMUST00000160116.4 ENSMUST00000160116.5 ENSMUST00000160116.6 ENSMUST00000160116.7 IMPG2_MOUSE Q80XH2 Q810Y3 Q8C8E4 uc289fby.1 uc289fby.2 Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin. Photoreceptor outer segment membrane ; Single-pass type I membrane protein Photoreceptor inner segment membrane ; Single-pass type I membrane protein Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80XH2-1; Sequence=Displayed; Name=2; IsoId=Q80XH2-2; Sequence=VSP_031612; Expressed in the retina (at protein level) (PubMed:12589770, PubMed:29777959). Expressed in the pineal gland (PubMed:12589770). Increasing expression in retina from 15 dpc to adulthood: expressed at P8 when photoreceptor outer segments are in active stages of elongation; elevated expression at P10 in the developing IPM and at P15 in the region adjacent to the retina pigment epithelium (RPE). From P18 to P35, more homogeneously present in the IPM surrounding both cones and rods. Sequence=AAO21221.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAO21221.1; Type=Frameshift; Evidence=; extracellular matrix structural constituent hyaluronic acid binding visual perception biological_process heparin binding membrane integral component of membrane extracellular matrix interphotoreceptor matrix receptor complex uc289fby.1 uc289fby.2 
ENSMUST00000160117.2 Slain1os ENSMUST00000160117.2 SLAIN motif family, member 1, opposite strand (from RefSeq NR_045148.1) ENSMUST00000160117.1 NR_045148 uc007uwu.1 uc007uwu.2 uc007uwu.3 uc007uwu.4 uc007uwu.1 uc007uwu.2 uc007uwu.3 uc007uwu.4 
ENSMUST00000160126.3 ENSMUSG00000121451 ENSMUST00000160126.3 ENSMUSG00000121451 (from geneSymbol) AK138922 ENSMUST00000160126.1 ENSMUST00000160126.2 uc291bbj.1 uc291bbj.2 uc291bbj.1 uc291bbj.2 
ENSMUST00000160137.2 A730090N16Rik ENSMUST00000160137.2 RIKEN cDNA A730090N16 gene (from RefSeq NR_040390.1) ENSMUST00000160137.1 NR_040390 uc008pkm.1 uc008pkm.2 uc008pkm.3 uc008pkm.1 uc008pkm.2 uc008pkm.3 
ENSMUST00000160144.9 Rnf146 ENSMUST00000160144.9 ring finger protein 146, transcript variant 4 (from RefSeq NM_026518.4) E0CX97 ENSMUST00000160144.1 ENSMUST00000160144.2 ENSMUST00000160144.3 ENSMUST00000160144.4 ENSMUST00000160144.5 ENSMUST00000160144.6 ENSMUST00000160144.7 ENSMUST00000160144.8 NM_026518 Q3TF93 Q3U6Y7 Q9CZW6 RN146_MOUSE uc007eta.1 uc007eta.2 uc007eta.3 E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein (By similarity). Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (PubMed:21602803, PubMed:21825151). Prevents nuclear translocation of AIFM1 in a PAR- binding dependent manner (PubMed:21602803, PubMed:21825151). Does not affect PARP1 activation. Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (PubMed:21602803, PubMed:21825151). Promotes cell survival after gamma-irradiation. Facilitates DNA repair (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation. Q9CZW6; P51668: UBE2D1; Xeno; NbExp=2; IntAct=EBI-16124494, EBI-743540; Cytoplasm, cytosol Nucleus Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding (By similarity). Expressed at relatively high levels in the brain. Also present in spleen, heart, kidney, testis and liver. In the brain, expressed in the cerebellum, hippocampus, striatum, cortex, frontal cortex and, at lowest levels, in olfactory bulb (at protein level). Predominantly expressed in neurons. Up-regulated in cortical neurons by treatment with N-methyl- D-aspartate (NMDA). Toxic doses of NMDA fail to induce Iduna expression. Sublethal exposure to oxygen-glucose deprivation also induces Iduna protein expression. Also induced by treatments that result in resistance to subsequent ischemic injury, such as 5 minute bilateral common carotid artery occlusion (at protein level). The WWE domain mediates non-covalent PAR-binding. Ubiquitinated; autoubiquitinated. Autoubiquitination is enhanced upon PAR-binding (By similarity). Was named Iduna after the Norse goddess of protection and eternal youth. ubiquitin-protein transferase activity protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane ubiquitin-dependent protein catabolic process zinc ion binding Wnt signaling pathway protein ubiquitination transferase activity metal ion binding protein autoubiquitination ubiquitin protein ligase activity protein K48-linked ubiquitination poly-ADP-D-ribose binding positive regulation of canonical Wnt signaling pathway negative regulation of hydrogen peroxide-induced cell death uc007eta.1 uc007eta.2 uc007eta.3 
ENSMUST00000160147.8 Man2c1 ENSMUST00000160147.8 mannosidase, alpha, class 2C, member 1 (from RefSeq NM_028636.2) ENSMUST00000160147.1 ENSMUST00000160147.2 ENSMUST00000160147.3 ENSMUST00000160147.4 ENSMUST00000160147.5 ENSMUST00000160147.6 ENSMUST00000160147.7 MA2C1_MOUSE Man2c1 NM_028636 Q3ZCX9 Q91W89 uc009pud.1 uc009pud.2 uc009pud.3 Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm. Reaction=Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.; EC=3.2.1.24; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Inhibited by 1,4-dideoxy-1,4-imino-d-mannitol (DIM) and EDTA. Cytoplasm Expressed in kidney and liver (at protein level) (PubMed:24550399). Widely expressed, with highest levels in lung, ovary and testis (PubMed:16904268). Also detected at lower levels in heart, brain, liver, spleen, kidney and thymus (PubMed:16904268). Viable and fertile with no gross defects. Loss of neutral mannosidase activity leading to accumulation of free higher- order oligosaccharides such as Man(8-9)GlcNAc(1) in many organs, particularly liver and heart. Tissues show histopathological changes with strongest defects observed in liver, small intestine, kidney and central nervous system (CNS). In liver, hepatocytes appear swollen with increased levels of glycogen and accumulation of lipid droplets. In the small intestine, enterocytes accumulate glycogen apically and also develop vacuoles in the basal cell region. In the CNS, neurons in isocortex lamina V show signs of degeneration with formation of vacuoles in basal cell regions. Vacuolation is also found in glial cells of white matter tracts. In kidney, there are signs of fibrosis along Bowman's capsule and a small number of glomeruli appear to be collapsed. Belongs to the glycosyl hydrolase 38 family. catalytic activity alpha-mannosidase activity nucleoplasm cytoplasm carbohydrate metabolic process mannose metabolic process metabolic process oligosaccharide catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds carbohydrate binding metal ion binding uc009pud.1 uc009pud.2 uc009pud.3 
ENSMUST00000160149.2 Fhitos ENSMUST00000160149.2 fragile histidine triad gene, opposite strand (from RefSeq NR_131139.1) ENSMUST00000160149.1 NR_131139 uc056yvr.1 uc056yvr.2 uc056yvr.1 uc056yvr.2 
ENSMUST00000160160.6 Gm42669 ENSMUST00000160160.6 Gm42669 (from geneSymbol) A0A805TBR8 A0A805TBR8_MOUSE BC106106 ENSMUST00000160160.1 ENSMUST00000160160.2 ENSMUST00000160160.3 ENSMUST00000160160.4 ENSMUST00000160160.5 Gm42669 uc290xvy.1 uc290xvy.2 uc290xvy.3 uc290xvy.1 uc290xvy.2 uc290xvy.3 
ENSMUST00000160177.3 E430024P14Rik ENSMUST00000160177.3 predicted gene 1604A, transcript variant 6 (from RefSeq NR_168939.1) ENSMUST00000160177.1 ENSMUST00000160177.2 NR_168939 uc008aiq.1 uc008aiq.2 uc008aiq.1 uc008aiq.2 
ENSMUST00000160178.3 Gm15647 ENSMUST00000160178.3 Gm15647 (from geneSymbol) ENSMUST00000160178.1 ENSMUST00000160178.2 uc287sas.1 uc287sas.2 uc287sas.3 uc287sas.1 uc287sas.2 uc287sas.3 
ENSMUST00000160180.9 Cyb5a ENSMUST00000160180.9 cytochrome b5 type A (microsomal), transcript variant 1 (from RefSeq NM_025797.4) Cyb5 Cyb5a ENSMUST00000160180.1 ENSMUST00000160180.2 ENSMUST00000160180.3 ENSMUST00000160180.4 ENSMUST00000160180.5 ENSMUST00000160180.6 ENSMUST00000160180.7 ENSMUST00000160180.8 NM_025797 Q544Z9 Q544Z9_MOUSE uc008fuw.1 uc008fuw.2 uc008fuw.3 uc008fuw.4 Endoplasmic reticulum membrane ; Single-pass membrane protein ; Cytoplasmic side Microsome membrane ; Single-pass membrane protein ; Cytoplasmic side Belongs to the cytochrome b5 family. endoplasmic reticulum endoplasmic reticulum membrane cytosol membrane integral component of membrane enzyme binding heme binding intracellular membrane-bounded organelle response to cadmium ion metal ion binding uc008fuw.1 uc008fuw.2 uc008fuw.3 uc008fuw.4 
ENSMUST00000160182.2 Gm16239 ENSMUST00000160182.2 predicted gene 16239 (from RefSeq NR_188942.1) ENSMUST00000160182.1 NR_188942 uc287ulb.1 uc287ulb.2 uc287ulb.1 uc287ulb.2 
ENSMUST00000160197.6 Exoc6b ENSMUST00000160197.6 exocyst complex component 6B (from RefSeq NM_177077.2) A6H5Z3 ENSMUST00000160197.1 ENSMUST00000160197.2 ENSMUST00000160197.3 ENSMUST00000160197.4 ENSMUST00000160197.5 EXC6B_MOUSE NM_177077 Q3UN15 Sec15b Sec15l2 uc009cpa.1 uc009cpa.2 uc009cpa.3 uc009cpa.4 Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A6H5Z3-1; Sequence=Displayed; Name=2; IsoId=A6H5Z3-2; Sequence=VSP_040840, VSP_040841; Belongs to the SEC15 family. exocyst molecular_function exocytosis Golgi to plasma membrane transport vesicle docking involved in exocytosis uc009cpa.1 uc009cpa.2 uc009cpa.3 uc009cpa.4 
ENSMUST00000160211.2 Gstt4 ENSMUST00000160211.2 glutathione S-transferase, theta 4 (from RefSeq NM_029472.3) ENSMUST00000160211.1 GSTT4_MOUSE Gstt4 NM_029472 Q9D4P7 uc007fre.1 uc007fre.2 uc007fre.3 uc007fre.4 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Homodimer. Cytoplasm Belongs to the GST superfamily. Theta family. glutathione transferase activity cytoplasm glutathione metabolic process transferase activity uc007fre.1 uc007fre.2 uc007fre.3 uc007fre.4 
ENSMUST00000160216.8 Cntn5 ENSMUST00000160216.8 contactin 5, transcript variant 1 (from RefSeq NM_001170787.1) CNTN5_MOUSE E0CYC2 ENSMUST00000160216.1 ENSMUST00000160216.2 ENSMUST00000160216.3 ENSMUST00000160216.4 ENSMUST00000160216.5 ENSMUST00000160216.6 ENSMUST00000160216.7 NM_001170787 P68500 uc012goa.1 uc012goa.2 uc012goa.3 Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons (By similarity). Involved in neuronal activity in the auditory system. Interacts with PTPRG. Cell membrane ; Lipid-anchor, GPI- anchor Expressed in the nervous system. Preferentially expressed in the central auditory pathways. Specifically expressed in the postnatal nervous system, reaching a maximum level at 3 weeks postnatal. Belongs to the immunoglobulin superfamily. Contactin family. cytosol plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules axon guidance sensory perception of sound membrane axon anchored component of membrane dendrite self-avoidance protein binding involved in cell-cell adhesion GABA-ergic synapse anchored component of presynaptic membrane presynapse assembly uc012goa.1 uc012goa.2 uc012goa.3 
ENSMUST00000160223.4 Ang6 ENSMUST00000160223.4 angiogenin, ribonuclease A family, member 6 (from RefSeq NM_001011876.2) Ang6 ENSMUST00000160223.1 ENSMUST00000160223.2 ENSMUST00000160223.3 NM_001011876 Q5GAN0 Q5GAN0_MOUSE uc288str.1 uc288str.2 uc288str.3 Cytoplasmic vesicle, secretory vesicle lumen Nucleus, nucleolus Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity ribonuclease activity cellular_component hydrolase activity nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis uc288str.1 uc288str.2 uc288str.3 
ENSMUST00000160241.2 Gm15810 ENSMUST00000160241.2 Gm15810 (from geneSymbol) ENSMUST00000160241.1 uc288mjc.1 uc288mjc.2 uc288mjc.1 uc288mjc.2 
ENSMUST00000160248.8 Zfat ENSMUST00000160248.8 zinc finger and AT hook domain containing, transcript variant 1 (from RefSeq NM_001145888.2) B2C322 ENSMUST00000160248.1 ENSMUST00000160248.2 ENSMUST00000160248.3 ENSMUST00000160248.4 ENSMUST00000160248.5 ENSMUST00000160248.6 ENSMUST00000160248.7 Gm922 NM_001145888 Q7TS63 ZFAT_MOUSE Zfat1 Zfp406 Znf406 uc011zto.1 uc011zto.2 uc011zto.3 May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated. Nucleus Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TS63-1; Sequence=Displayed; Name=2; IsoId=Q7TS63-2; Sequence=VSP_034940, VSP_034941; Detected in spleen and thymus but not in liver, muscle, heart, kidney, brain, bone marrow or pancreas. Expressed in CD19+, CD4+ and CD8+ lymphocytes but not in CD11b+ lymphocytes or peritoneal macrophages (at protein level). Up-regulated during the transition from CD4-/CD8- to CD4+/CD8+ thymocytes. transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding hematopoietic progenitor cell differentiation nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm cytosol regulation of transcription, DNA-templated hemopoiesis positive regulation of transcription from RNA polymerase II promoter metal ion binding spongiotrophoblast layer development uc011zto.1 uc011zto.2 uc011zto.3 
ENSMUST00000160249.8 Rnf123 ENSMUST00000160249.8 Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit. Functions also as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity. Interacts with the N- terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS. (from UniProt Q5XPI3) BC057082 ENSMUST00000160249.1 ENSMUST00000160249.2 ENSMUST00000160249.3 ENSMUST00000160249.4 ENSMUST00000160249.5 ENSMUST00000160249.6 ENSMUST00000160249.7 Kpc1 Q5XPI3 Q6PGE0 RN123_MOUSE uc292lbf.1 uc292lbf.2 Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit. Functions also as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity. Interacts with the N- terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with UBAC1 and CDKN1B via its N-terminal domain. Interacts with RIGI (via N-terminus) and IFIH1 (via N-terminus). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5XPI3-1; Sequence=Displayed; Name=2; IsoId=Q5XPI3-2; Sequence=VSP_020651; Ubiquitinated, leading to its degradation. Deubiquitinated by USP19, thereby stimulating CDKN1B ubiquitin-dependent degradation. ubiquitin-protein transferase activity cytoplasm cytosol protein ubiquitination transferase activity nuclear membrane metal ion binding proteolysis involved in cellular protein catabolic process uc292lbf.1 uc292lbf.2 
ENSMUST00000160262.9 Armc2 ENSMUST00000160262.9 Required for sperm flagellum axoneme organization and function (PubMed:30686508). Involved in axonemal central pair complex assembly and/or stability (PubMed:30686508). (from UniProt Q3URY6) AK141039 ARMC2_MOUSE Armc2 ENSMUST00000160262.1 ENSMUST00000160262.2 ENSMUST00000160262.3 ENSMUST00000160262.4 ENSMUST00000160262.5 ENSMUST00000160262.6 ENSMUST00000160262.7 ENSMUST00000160262.8 Q3URY6 uc287quc.1 uc287quc.2 Required for sperm flagellum axoneme organization and function (PubMed:30686508). Involved in axonemal central pair complex assembly and/or stability (PubMed:30686508). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3URY6-1; Sequence=Displayed; Name=2; IsoId=Q3URY6-2; Sequence=VSP_024495, VSP_024496; Male mice are infertile, while female fertility is not affected (PubMed:30686508). Spermatozoa exhibit multiple morphologic abnormalities including short, thick, and/or coiled flagella, whereas sperm heads conserve an overall typical hooked shape (PubMed:30686508). [Isoform 2]: Due to intron retention. molecular_function cellular_component biological_process uc287quc.1 uc287quc.2 
ENSMUST00000160263.2 Gm16540 ENSMUST00000160263.2 Gm16540 (from geneSymbol) ENSMUST00000160263.1 uc290haa.1 uc290haa.2 uc290haa.1 uc290haa.2 
ENSMUST00000160272.8 Pard3 ENSMUST00000160272.8 par-3 family cell polarity regulator, transcript variant 5 (from RefSeq NM_001309391.1) A5D6P2 A5D6P2_MOUSE ENSMUST00000160272.1 ENSMUST00000160272.2 ENSMUST00000160272.3 ENSMUST00000160272.4 ENSMUST00000160272.5 ENSMUST00000160272.6 ENSMUST00000160272.7 NM_001309391 Pard3 uc009nzj.1 uc009nzj.2 uc009nzj.3 Cell junction, tight junction Endomembrane system Belongs to the PAR3 family. phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding cell-cell junction bicellular tight junction protein targeting to membrane protein phosphatase binding cell junction phosphatidylinositol-3-phosphate binding macromolecular complex identical protein binding neuronal cell body axonal growth cone regulation of cellular localization bicellular tight junction assembly establishment of epithelial cell polarity uc009nzj.1 uc009nzj.2 uc009nzj.3 
ENSMUST00000160278.3 Gm16133 ENSMUST00000160278.3 Gm16133 (from geneSymbol) ENSMUST00000160278.1 ENSMUST00000160278.2 uc288nsw.1 uc288nsw.2 uc288nsw.1 uc288nsw.2 
ENSMUST00000160279.8 Tex56 ENSMUST00000160279.8 testis expressed 56 (from RefSeq NM_025750.3) ENSMUST00000160279.1 ENSMUST00000160279.2 ENSMUST00000160279.3 ENSMUST00000160279.4 ENSMUST00000160279.5 ENSMUST00000160279.6 ENSMUST00000160279.7 NM_025750 Q497N7 Q9D433 Q9D460 TEX56_MOUSE Tex56 uc007qbt.1 uc007qbt.2 uc007qbt.3 uc007qbt.4 Expressed predominantly in the testis. Deficient mice are viable and have normal fertility. Sequence=BAB30424.1; Type=Frameshift; Evidence=; Sequence=BAB30456.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc007qbt.1 uc007qbt.2 uc007qbt.3 uc007qbt.4 
ENSMUST00000160285.2 Dnai3 ENSMUST00000160285.2 dynein axonemal intermediate chain 3 (from RefSeq NM_172864.3) B2RY71 DNAI3_MOUSE ENSMUST00000160285.1 NM_172864 Wdr63 uc008rqw.1 uc008rqw.2 uc008rqw.3 uc008rqw.4 Acts as a negative regulator of cell migration, invasion, and metastasis downstream of p53/TP53, through inhibition of Arp2/3 complex-mediated actin polymerization (By similarity). Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function (PubMed:30060180). May play a role in osteogenesis of dental tissue- derived mesenchymal stem cells (PubMed:25498833). Interacts with ACTR2; this interaction reduces binding of the Arp2/3 complex to the VCA domain of nucleation promoting factors (By similarity). Part of the multisubunit axonemal dynein complex formed at least of two heavy chains and a number of intermediate and light chains (PubMed:30060180). Found in a associated with the catalytic heavy chain DNAH2, the intermediate chain DNAI4, and the light chain DYNLT1 (PubMed:30060180). Cytoplasm Strongly expressed in the testes (PubMed:26501274). Detected also in brain and lung tissues (PubMed:26501274). Deficient mice shown no overt abnormalities in body size, development, behavior, or fertility. microtubule-based movement inner dynein arm inner dynein arm assembly dynein light chain binding dynein heavy chain binding cilium movement involved in cell motility ATP-dependent microtubule motor activity, plus-end-directed uc008rqw.1 uc008rqw.2 uc008rqw.3 uc008rqw.4 
ENSMUST00000160289.9 Nsmce4a ENSMUST00000160289.9 NSE4 homolog A, SMC5-SMC6 complex component (from RefSeq NM_001162855.1) ENSMUST00000160289.1 ENSMUST00000160289.2 ENSMUST00000160289.3 ENSMUST00000160289.4 ENSMUST00000160289.5 ENSMUST00000160289.6 ENSMUST00000160289.7 ENSMUST00000160289.8 G3XA30 G3XA30_MOUSE NM_001162855 Nsmce4a uc009kad.1 uc009kad.2 uc009kad.3 Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. Component of the SMC5-SMC6 complex. Nucleus Belongs to the NSE4 family. molecular_function nucleus nucleoplasm DNA repair DNA recombination cellular response to DNA damage stimulus nuclear body Smc5-Smc6 complex positive regulation of response to DNA damage stimulus uc009kad.1 uc009kad.2 uc009kad.3 
ENSMUST00000160290.8 BC035044 ENSMUST00000160290.8 cDNA sequence BC035044, transcript variant 1 (from RefSeq NM_001254946.1) BC035044 E0CXF8 E0CXF8_MOUSE ENSMUST00000160290.1 ENSMUST00000160290.2 ENSMUST00000160290.3 ENSMUST00000160290.4 ENSMUST00000160290.5 ENSMUST00000160290.6 ENSMUST00000160290.7 NM_001254946 uc009eet.1 uc009eet.2 uc009eet.3 molecular_function cellular_component biological_process uc009eet.1 uc009eet.2 uc009eet.3 
ENSMUST00000160298.2 Gm8113 ENSMUST00000160298.2 Gm8113 (from geneSymbol) AK142214 E0CXS8 E0CXS8_MOUSE ENSMUST00000160298.1 Gm8113 uc288stl.1 uc288stl.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288stl.1 uc288stl.2 
ENSMUST00000160300.2 Nxph1 ENSMUST00000160300.2 May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins. (from UniProt Q61200) A6H6P7 AK047847 ENSMUST00000160300.1 NXPH1_MOUSE Nph1 Q61200 Q8BHJ2 Q8BLP4 uc009ayb.1 uc009ayb.2 uc009ayb.3 May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins. Secreted Brain, only in a scattered subpopulation of neurons that probably represent inhibitory interneurons. May be proteolytically processed at the boundary between the N- terminal non-conserved and the central conserved domain in neuron-like cells. Belongs to the neurexophilin family. receptor binding extracellular region uc009ayb.1 uc009ayb.2 uc009ayb.3 
ENSMUST00000160334.8 Gm16573 ENSMUST00000160334.8 predicted gene 16573 (from RefSeq NR_153784.1) ENSMUST00000160334.1 ENSMUST00000160334.2 ENSMUST00000160334.3 ENSMUST00000160334.4 ENSMUST00000160334.5 ENSMUST00000160334.6 ENSMUST00000160334.7 NR_153784 uc288uto.1 uc288uto.2 uc288uto.1 uc288uto.2 
ENSMUST00000160351.2 Gm16243 ENSMUST00000160351.2 Gm16243 (from geneSymbol) ENSMUST00000160351.1 uc288pgk.1 uc288pgk.2 uc288pgk.1 uc288pgk.2 
ENSMUST00000160359.2 Plod2 ENSMUST00000160359.2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2, transcript variant 1 (from RefSeq NM_001142916.1) E9Q718 E9Q718_MOUSE ENSMUST00000160359.1 NM_001142916 Plod2 uc009rav.1 uc009rav.2 uc009rav.3 uc009rav.4 uc009rav.5 Reaction=2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L- lysyl-[collagen] + CO2 + succinate; Xref=Rhea:RHEA:16569, Rhea:RHEA- COMP:12751, Rhea:RHEA-COMP:12752, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:133442; EC=1.14.11.4; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence=; Endoplasmic reticulum membrane ; Peripheral membrane protein ; Lumenal side response to hypoxia iron ion binding procollagen-lysine 5-dioxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen peptidyl-lysine hydroxylation L-ascorbic acid binding hydroxylysine biosynthetic process oxidation-reduction process uc009rav.1 uc009rav.2 uc009rav.3 uc009rav.4 uc009rav.5 
ENSMUST00000160368.2 Gm16337 ENSMUST00000160368.2 Gm16337 (from geneSymbol) ENSMUST00000160368.1 uc290duy.1 uc290duy.2 uc290duy.1 uc290duy.2 
ENSMUST00000160378.3 Acat3 ENSMUST00000160378.3 acetyl-Coenzyme A acetyltransferase 3 (from RefSeq NM_001410277.1) Acat3 ENSMUST00000160378.1 ENSMUST00000160378.2 F2Z459 NM_001410277 Q80X81 Q80X81_MOUSE uc289hbj.1 uc289hbj.2 Lipid metabolism. Belongs to the thiolase-like superfamily. Thiolase family. catalytic activity acetyl-CoA C-acetyltransferase activity acetyl-CoA C-acyltransferase activity nucleus nucleolus cytoplasm mitochondrion cytosol fatty acid beta-oxidation transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups uc289hbj.1 uc289hbj.2 
ENSMUST00000160379.4 Cdk5r2 ENSMUST00000160379.4 cyclin dependent kinase 5, regulatory subunit 2 (from RefSeq NM_009872.3) CD5R2_MOUSE ENSMUST00000160379.1 ENSMUST00000160379.2 ENSMUST00000160379.3 NM_009872 Nck5ai O35277 O35926 Q9QYD1 uc007bng.1 uc007bng.2 uc007bng.3 uc007bng.4 Activator of CDK5/TPKII. Heterodimer of a catalytic subunit and a regulatory subunit. Cell membrane ; Lipid-anchor ; Cytoplasmic side Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is essential for the proper distribution of CDK5R2 (p39) (By similarity). Belongs to the cyclin-dependent kinase 5 activator family. neuron migration actin binding cytoplasm plasma membrane cytoskeletal protein binding lipid binding membrane cyclin-dependent protein kinase 5 holoenzyme complex cerebellum development superior olivary nucleus maturation hippocampus development layer formation in cerebral cortex growth cone neuron projection positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of protein kinase activity positive regulation of calcium ion-dependent exocytosis cyclin-dependent protein serine/threonine kinase activator activity uc007bng.1 uc007bng.2 uc007bng.3 uc007bng.4 
ENSMUST00000160385.2 4833422C13Rik ENSMUST00000160385.2 RIKEN cDNA 4833422C13 gene, transcript variant 3 (from RefSeq NR_015501.1) ENSMUST00000160385.1 NR_015501 uc011zcm.1 uc011zcm.2 uc011zcm.1 uc011zcm.2 
ENSMUST00000160392.9 Hand1 ENSMUST00000160392.9 Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (PubMed:9500551, PubMed:16759287). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (PubMed:7791788). Acts as a transcriptional repressor of SOX15 (PubMed:16759287). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). (from UniProt Q64279) AK146084 ENSMUST00000160392.1 ENSMUST00000160392.2 ENSMUST00000160392.3 ENSMUST00000160392.4 ENSMUST00000160392.5 ENSMUST00000160392.6 ENSMUST00000160392.7 ENSMUST00000160392.8 Ehand HAND1_MOUSE Hxt Q61099 Q64279 Thing1 uc287yie.1 uc287yie.2 Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (PubMed:9500551, PubMed:16759287). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (PubMed:7791788). Acts as a transcriptional repressor of SOX15 (PubMed:16759287). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND2 and HEY1, HEY2 and HEYL (hairy-related transcription factors). Interacts with MDFIC. Interacts with SOX15; the interaction enhances HAND1-induced differentiation of trophoblast giant cells (PubMed:16759287). Q64279; Q64279: Hand1; NbExp=2; IntAct=EBI-81361, EBI-81361; Q64279; Q61039: Hand2; NbExp=3; IntAct=EBI-81361, EBI-81388; Q64279; P15806: Tcf3; NbExp=2; IntAct=EBI-81361, EBI-81370; Nucleus, nucleoplasm Nucleus, nucleolus Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity. Smooth muscle cells of the gut and adrenal tissue. Present as a maternal transcript in the egg as well as during cleavage development before blastocyst formation. At 7.5 dpc, strongly expressed in all trophoblast cells (PubMed:16759287). Expression seen in the ectoplacental cone and extraembryonic mesodermal components of the amnion, allantois and visceral yolk sac. This high extraembryonic expression persists in the embryonic component of the placenta throughout development. In the embryo, expressed at 7.75 dpc in the lateral mesoderm along the entire length of the embryo as well as throughout the precardiogenic mesoderm. At 8.0 dpc, in the developing heart, expression becomes restricted to the rostral and caudal regions of the straight heart tube, which are fated to form the conotruncus and left ventricle, respectively. Symmetric expression is observed along the left-right axis in the caudal heart tube and lateral mesoderm. As cardiac looping occurs, the interrupted anterior-posterior patterning is maintained with expression in the future left, but not right ventricle. Expressed in the myocardium, but not in the endocardium, and specifically on the greater curvature of the looping heart which is opposed to the pericardium. After day 10.5 dpc, the high cardiac expression level declines abruptly. By 13.5 dpc, expression in the heart is restricted to the regions of valve formation. Besides the heart, expression becomes detectable in the gut at 9.0 dpc. At 10.0 dpc, expressed also in the lateral mesoderm and in the neural crest- derived branchial arches. At 10.5 dpc prominent expression in the gut, pharyngeal arches and in sympathetic ganglion primordia. At that stage, a low level of transient expression is seen in the distal posterior region of the limb bud. At 12 dpc expressed in the conceptus trophoblast giant cell layer in the placenta (PubMed:16759287). At 13.5 dpc expressed in neural crest derivatives, with abundant expression in the autonomic nervous system and adrenal medulla. Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to translocation into the nucleoplasm, allowing dimerization and transcription factor activity. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis in utero embryonic development mesoderm formation cell fate determination blastocyst development trophectodermal cell differentiation heart looping heart morphogenesis embryonic heart tube formation cardiac left ventricle formation cardiac right ventricle formation DNA binding transcription coactivator activity protein binding nucleus nucleoplasm nucleolus cytoplasm transcription from RNA polymerase II promoter multicellular organism development heart development transcription factor binding enzyme binding cell differentiation embryonic heart tube development odontogenesis of dentin-containing tooth identical protein binding protein homodimerization activity bHLH transcription factor binding negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity ventricular cardiac muscle tissue morphogenesis cardiac septum morphogenesis mesenchyme development cartilage morphogenesis trophoblast giant cell differentiation determination of heart left/right asymmetry RNA polymerase II transcription factor complex negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding uc287yie.1 uc287yie.2 
ENSMUST00000160399.8 Echdc1 ENSMUST00000160399.8 enoyl Coenzyme A hydratase domain containing 1, transcript variant 2 (from RefSeq NM_001110195.1) ECHD1_MOUSE ENSMUST00000160399.1 ENSMUST00000160399.2 ENSMUST00000160399.3 ENSMUST00000160399.4 ENSMUST00000160399.5 ENSMUST00000160399.6 ENSMUST00000160399.7 NM_001110195 Q3U8C0 Q3UM30 Q8C185 Q9CTC5 Q9D9V3 uc007esw.1 uc007esw.2 uc007esw.3 uc007esw.4 Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but has also some activity on the (R)-isomer. Also has methylmalonyl- CoA decarboxylase activity at lower level. Reaction=(2S)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2; Xref=Rhea:RHEA:32131, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57371, ChEBI:CHEBI:60909; EC=4.1.1.94; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32132; Evidence=; Reaction=(S)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA; Xref=Rhea:RHEA:61340, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57327, ChEBI:CHEBI:57392; EC=4.1.1.94; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61341; Evidence=; Reaction=(2R)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2; Xref=Rhea:RHEA:59540, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57371, ChEBI:CHEBI:85316; EC=4.1.1.94; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59541; Evidence=; Kinetic parameters: KM=0.96 uM for (S)-ethylmalonyl-CoA (in absence of ATP) ; KM=6.5 uM for (S)-ethylmalonyl-CoA (in presence of 5 mM ATP) ; KM=3.1 uM for (S)-methylmalonyl-CoA (in absence of ATP) ; KM=15.1 uM for (S)-methylmalonyl-CoA (in presence of 5 mM ATP) ; Note=kcat is 10 sec(-1) with (S)-ethylmalonyl-CoA as substrate (in presence of 5 mM ATP). kcat is 1.68 sec(-1) with (S)-methylmalonyl- CoA as substrate (in presence of 5 mM ATP). ; Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D9V3-1; Sequence=Displayed; Name=2; IsoId=Q9D9V3-2; Sequence=VSP_022499; Belongs to the enoyl-CoA hydratase/isomerase family. catalytic activity enoyl-CoA hydratase activity cytoplasm cytosol fatty acid beta-oxidation decarboxylation-driven active transmembrane transporter activity lyase activity carboxy-lyase activity transmembrane transport uc007esw.1 uc007esw.2 uc007esw.3 uc007esw.4 
ENSMUST00000160422.8 Cpsf4 ENSMUST00000160422.8 cleavage and polyadenylation specific factor 4, transcript variant 4 (from RefSeq NM_001374716.1) Cpsf4 E0CXT7 E0CXT7_MOUSE ENSMUST00000160422.1 ENSMUST00000160422.2 ENSMUST00000160422.3 ENSMUST00000160422.4 ENSMUST00000160422.5 ENSMUST00000160422.6 ENSMUST00000160422.7 NM_001374716 uc291brt.1 uc291brt.2 Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). Component of the cleavage and polyadenylation specificity factor (CPSF) complex. Nucleus Belongs to the CPSF4/YTH1 family. nucleic acid binding zinc ion binding metal ion binding uc291brt.1 uc291brt.2 
ENSMUST00000160424.8 Cacna1i ENSMUST00000160424.8 calcium channel, voltage-dependent, alpha 1I subunit (from RefSeq NM_001044308.2) Cacna1i E9Q7P2 E9Q7P2_MOUSE ENSMUST00000160424.1 ENSMUST00000160424.2 ENSMUST00000160424.3 ENSMUST00000160424.4 ENSMUST00000160424.5 ENSMUST00000160424.6 ENSMUST00000160424.7 NM_001044308 uc009var.1 uc009var.2 uc009var.3 Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Membrane ; Multi- pass membrane protein Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. voltage-gated sodium channel complex ion channel activity voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated sodium channel activity calcium channel activity plasma membrane voltage-gated calcium channel complex ion transport calcium ion transport low voltage-gated calcium channel activity membrane integral component of membrane neuronal action potential flagellated sperm motility sleep regulation of ion transmembrane transport sodium ion transmembrane transport regulation of membrane potential positive regulation of calcium ion-dependent exocytosis transmembrane transport calcium ion transport into cytosol calcium ion import calcium ion transmembrane transport membrane depolarization during action potential uc009var.1 uc009var.2 uc009var.3 
ENSMUST00000160432.3 Gm16231 ENSMUST00000160432.3 Gm16231 (from geneSymbol) ENSMUST00000160432.1 ENSMUST00000160432.2 uc290krc.1 uc290krc.2 uc290krc.3 uc290krc.1 uc290krc.2 uc290krc.3 
ENSMUST00000160433.3 Kcnc1 ENSMUST00000160433.3 potassium voltage gated channel, Shaw-related subfamily, member 1, transcript variant 1 (from RefSeq NM_001112739.2) E9PVV3 ENSMUST00000160433.1 ENSMUST00000160433.2 KCNC1_MOUSE Kcnc1 NM_001112739 P15388 uc009gyn.1 uc009gyn.2 uc009gyn.3 uc009gyn.4 Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2599109, PubMed:1400413). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons. Heteromultimer with KCNG3, KCNG4 and KCNV2 (By similarity). Heteromultimer with KCNC2 (By similarity). Heterotetramer with KCNC3 (By similarity). Interacts with the ancillary subunits KCNE1 and KCNE2; the interaction modulates channel activity (By similarity). Cell membrane ulti-pass membrane protein Cell projection, axon Presynaptic cell membrane Note=Localizes in parallel fiber membranes, distributed on the perisynaptic and extrasynaptic membranes away from the active zones. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=KV3.1; IsoId=P15388-1; Sequence=Displayed; Name=2; IsoId=P15388-3; Sequence=VSP_058604; Detected in cerebellum (PubMed:11517255, PubMed:15217387). Detected in brain (at protein level) (PubMed:9037088). Detected in brain (PubMed:9037088). The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. N-glycosylated; contains sialylated glycans. Mutant mice are born at the expected Mendelian rate. They are viable and fertile, but have lower body weight than wild-type. They have normal spontaneous locomotor activity, but impaired motor skills (PubMed:9037088). Mice lacking both Kcnc3 and Kcnc1 are born at the expected Mendelian rate, but the pups do not thrive and all die about 26 days after birth when kept together with other littermates. Their failure to thrive may be due to motor problems; mutant pups survive when fed separately, but 45 days after birth their body weight is only 50 to 60 % of that of wild-type (PubMed:11517255). They appear uncoordinated and display severe ataxia, myoclonus and spontaneous whole-body muscle jerks, but display no obvious alterations in brain morphology (PubMed:11517255, PubMed:15217387, PubMed:16923152). Mutant mice are also much more sensitive to ethanol and fall sideways at ethanol concentrations that have no effect on wild-type mice (PubMed:11517255). They display increased locomotor and exploratory activity (PubMed:11517255, PubMed:15217387). Mice lacking Kcnc1 show reduced response to tremorogenic agent harmaline; mice lacking both Kcnc3 and Kcnc1 are resistant to the tremorogenic agent harmaline (PubMed:15217387). Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity protein binding plasma membrane ion transport potassium ion transport brain development voltage-gated potassium channel complex response to toxic substance response to light intensity cell surface response to auditory stimulus response to amine membrane integral component of membrane kinesin binding cerebellum development globus pallidus development axon dendrite axolemma neuron projection membrane dendrite membrane neuronal cell body membrane regulation of ion transmembrane transport positive regulation of ion transmembrane transport cellular response to drug response to potassium ion neuronal cell body calyx of Held ion channel binding protein homooligomerization protein tetramerization transmembrane transport response to fibroblast growth factor potassium ion transmembrane transport integral component of postsynaptic membrane integral component of presynaptic membrane regulation of presynaptic membrane potential voltage-gated ion channel activity involved in regulation of presynaptic membrane potential regulation of potassium ion transmembrane transport positive regulation of potassium ion transmembrane transport positive regulation of voltage-gated potassium channel activity response to nerve growth factor uc009gyn.1 uc009gyn.2 uc009gyn.3 uc009gyn.4 
ENSMUST00000160436.2 Tcerg1l ENSMUST00000160436.2 transcription elongation regulator 1-like (from RefSeq NM_183289.3) ENSMUST00000160436.1 NM_183289 Q3B807 Q80ZP6 Q8BT57 TCRGL_MOUSE uc012fvn.1 uc012fvn.2 uc012fvn.3 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3B807-1; Sequence=Displayed; Name=2; IsoId=Q3B807-2; Sequence=VSP_029926, VSP_029927; Name=3; IsoId=Q3B807-3; Sequence=VSP_029925; Sequence=AAH48631.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAI07235.1; Type=Erroneous initiation; Evidence=; Sequence=AAI07236.1; Type=Erroneous initiation; Evidence=; Sequence=BAC25528.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC25528.1; Type=Frameshift; Evidence=; nucleus biological_process uc012fvn.1 uc012fvn.2 uc012fvn.3 
ENSMUST00000160439.8 Zfand2b ENSMUST00000160439.8 zinc finger, AN1 type domain 2B, transcript variant 3 (from RefSeq NM_001159906.1) Airapl ENSMUST00000160439.1 ENSMUST00000160439.2 ENSMUST00000160439.3 ENSMUST00000160439.4 ENSMUST00000160439.5 ENSMUST00000160439.6 ENSMUST00000160439.7 NM_001159906 Q91X58 Q9D0W4 ZFN2B_MOUSE Zfand2b uc011wng.1 uc011wng.2 uc011wng.3 Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum (PubMed:24160817, PubMed:26337389, PubMed:26692333). It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum (PubMed:24160817). It also plays a role in the ubiquitin- mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed (PubMed:18467495, PubMed:26337389). May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:24160817, PubMed:26337389). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Binds 'Lys-48'-linked polyubiquitin chains of ubiquitinated proteins (PubMed:18467495, PubMed:24160817, PubMed:26876100). Associates with the proteasome complex; upon exposure to arsenite (PubMed:18467495, PubMed:26876100). Interacts (via VIM motif) with VCP; the interaction is direct (PubMed:24160817, PubMed:26337389). Interacts with BAG6 (PubMed:24160817, PubMed:26337389, PubMed:26876100). Interacts with IGF1R (nascent precursor form) (PubMed:26692333). Interacts with DERL1, FAF2, NPLOC4 and UFD1; probably through VCP (PubMed:24160817). Q91X58; Q9R1P4: Psma1; NbExp=2; IntAct=EBI-15701753, EBI-991653; Endoplasmic reticulum membrane ; Lipid-anchor The UIM domains specifically bind 'Lys-48'-linked ubiquitin polymers (PubMed:18467495, PubMed:26876100). The UIM domains mediate interaction with polyubiquitinated proteins (PubMed:18467495, PubMed:26337389). Phosphorylated by MAPK14 (Probable). Phosphorylation has no effect on association with the proteasome complex (Probable). Knockout mice undergo premature death due to the occurrence of myelo-proliferative neoplasms. The absence of Zfand2b plays a driver role in the development of these neoplasms by hyperactivating the insulin-like growth factor receptor signaling pathway. This is due to increased expression, in particular at the cell surface, of the IGF1R receptor. proteasome complex protein binding endoplasmic reticulum endoplasmic reticulum membrane SRP-dependent cotranslational protein targeting to membrane, translocation zinc ion binding membrane anchored component of membrane polyubiquitin binding K48-linked polyubiquitin binding ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process regulation of insulin-like growth factor receptor signaling pathway protein targeting to ER metal ion binding uc011wng.1 uc011wng.2 uc011wng.3 
ENSMUST00000160445.3 Gm16549 ENSMUST00000160445.3 Gm16549 (from geneSymbol) AK007062 ENSMUST00000160445.1 ENSMUST00000160445.2 uc288vop.1 uc288vop.2 uc288vop.3 uc288vop.1 uc288vop.2 uc288vop.3 
ENSMUST00000160456.8 Nos1ap ENSMUST00000160456.8 nitric oxide synthase 1 (neuronal) adaptor protein, transcript variant 1 (from RefSeq NM_001109985.3) CAPON_MOUSE Capon E9Q7B9 ENSMUST00000160456.1 ENSMUST00000160456.2 ENSMUST00000160456.3 ENSMUST00000160456.4 ENSMUST00000160456.5 ENSMUST00000160456.6 ENSMUST00000160456.7 Kiaa0464 NM_001109985 Nos1ap Q80TZ6 Q9D3A8 uc011wvt.1 uc011wvt.2 uc011wvt.3 Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862). Interacts with the PDZ domain of NOS1 or the second PDZ domain of DLG4 through its C-terminus. Interacts with RASD1 and SYN1, SYN2 and SYN3 via its PID domain. Forms a ternary complex with NOS1 and SYN1 (By similarity). Forms a ternary complex with NOS1 and RASD1. Cell projection, filopodium Cell projection, podosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D3A8-1; Sequence=Displayed; Name=2; IsoId=Q9D3A8-2; Sequence=VSP_012462, VSP_012463; protease binding regulation of heart rate by chemical signal nucleus cytoplasm mitochondrion cytosol biological_process Z disc PDZ domain binding sarcoplasmic reticulum membrane nitric-oxide synthase binding regulation of ventricular cardiac muscle cell membrane repolarization presynapse postsynapse postsynaptic actin cytoskeleton organization glutamatergic synapse negative regulation of neuron death regulation of high voltage-gated calcium channel activity positive regulation of peptidyl-cysteine S-nitrosylation caveola T-tubule nuclear membrane inward rectifier potassium channel complex L-type voltage-gated calcium channel complex uc011wvt.1 uc011wvt.2 uc011wvt.3 
ENSMUST00000160457.10 Zfp945 ENSMUST00000160457.10 zinc finger protein 945, transcript variant 2 (from RefSeq NM_177358.4) A630033E08Rik E9PYM8 ENSMUST00000160457.1 ENSMUST00000160457.2 ENSMUST00000160457.3 ENSMUST00000160457.4 ENSMUST00000160457.5 ENSMUST00000160457.6 ENSMUST00000160457.7 ENSMUST00000160457.8 ENSMUST00000160457.9 NM_177358 Q66L36 Q66L36_MOUSE Zfp945 uc008asc.1 uc008asc.2 uc008asc.3 nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated biological_process metal ion binding uc008asc.1 uc008asc.2 uc008asc.3 
ENSMUST00000160476.9 Cyp2c40 ENSMUST00000160476.9 cytochrome P450, family 2, subfamily c, polypeptide 40 (from RefSeq NM_010004.3) B2RTP3 CP240_MOUSE Cyp2c40 ENSMUST00000160476.1 ENSMUST00000160476.2 ENSMUST00000160476.3 ENSMUST00000160476.4 ENSMUST00000160476.5 ENSMUST00000160476.6 ENSMUST00000160476.7 ENSMUST00000160476.8 NM_010004 P56657 uc008hke.1 uc008hke.2 uc008hke.3 uc008hke.4 uc008hke.5 A cytochrome P450 monooxygenase that may play a major role in the metabolism of arachidonic acid in the intestinal tract (PubMed:10908295, PubMed:9721182). Exhibits regioselective hydroxylase and epoxidase activity toward arachidonic acid, producing 16(R)- hydroxyeicosatetraenoic acid (HETE) and (14R,15S)-epoxyeicosatrienoic acid (EpETrE) as major products (PubMed:10908295). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10908295). Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 16(R)-hydroxy-(5Z,8Z,11Z,14Z)- eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53308, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:137166; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53309; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = 16(S)-hydroxy-(5Z,8Z,11Z,14Z)- eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53312, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:137167; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53313; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131965; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49861; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH-- hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49856, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131964; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49857; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Lipid metabolism; arachidonate metabolism. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Liver, brain, kidney, and intestine, with trace amounts in lung and heart (PubMed:9721182, PubMed:10908295). Expressed throughout the intestinal tract, with higher expression levels in jejunum, cecum and colon (PubMed:10908295). Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding organelle membrane exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc008hke.1 uc008hke.2 uc008hke.3 uc008hke.4 uc008hke.5 
ENSMUST00000160490.2 Gm16553 ENSMUST00000160490.2 Gm16553 (from geneSymbol) ENSMUST00000160490.1 uc291xvc.1 uc291xvc.2 uc291xvc.1 uc291xvc.2 
ENSMUST00000160496.8 Ano2 ENSMUST00000160496.8 anoctamin 2, transcript variant 1 (from RefSeq NM_153589.2) ANO2_MOUSE Ano2 C4N788 ENSMUST00000160496.1 ENSMUST00000160496.2 ENSMUST00000160496.3 ENSMUST00000160496.4 ENSMUST00000160496.5 ENSMUST00000160496.6 ENSMUST00000160496.7 NM_153589 Q8C8N6 Q8CFW1 Tmem16b uc009duw.1 uc009duw.2 uc009duw.3 uc009duw.4 uc009duw.5 Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor- sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. Channel activity is repressed by chloride inhibitors; strongly by niflumic acid (NFA), partially by flufenamic acid (FFA), and only slightly by meclofenamic acid (MFA), 5-Nitro-2-(3- phenylpropylamino)benzoic acid (NPPB), 4-acetamido-4'-isothiocyanato- stilben-2,2'-disulfonate (SITS), and 4,4'-diisothiocyanatostilbene- 2,2'-disulfonic acid (DIDS). Component of a presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors. Interacts with DLG4 by its C-terminal region. Cell membrane ulti-pass membrane protein Expressed in retina, especially in the photoreceptor synaptic terminals, and in olfactory epithelium, particularly in sensory neurons (OSNs) and cilia (at protein level). Also observed in retinal pigment epithelium (RPE), olfactory bulb, brain, and cortex. Detected in the mantle layer of the neural tube and in the dorsal root ganglia at 14.5 dpc. In developing skin, expression is restricted to basal layers of the epidermis at 16.5 dpc. Glycosylated. The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. Belongs to the anoctamin family. Sequence=AAH33409.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC32073.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; intracellular calcium activated chloride channel activity chloride channel activity protein binding nucleoplasm plasma membrane ion transport chloride transport membrane integral component of membrane ion transmembrane transport chloride channel complex protein homodimerization activity protein heterodimerization activity protein dimerization activity non-motile cilium chloride transmembrane transport uc009duw.1 uc009duw.2 uc009duw.3 uc009duw.4 uc009duw.5 
ENSMUST00000160507.8 Sucla2 ENSMUST00000160507.8 succinate-Coenzyme A ligase, ADP-forming, beta subunit, transcript variant 1 (from RefSeq NM_011506.4) ENSMUST00000160507.1 ENSMUST00000160507.2 ENSMUST00000160507.3 ENSMUST00000160507.4 ENSMUST00000160507.5 ENSMUST00000160507.6 ENSMUST00000160507.7 NM_011506 Q3TVH1 Q8BGS6 Q9Z2I9 SUCB1_MOUSE Sucla2 uc007upy.1 uc007upy.2 uc007upy.3 ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Reaction=ATP + CoA + succinate = ADP + phosphate + succinyl-CoA; Xref=Rhea:RHEA:17661, ChEBI:CHEBI:30031, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:456216; EC=6.2.1.5; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP. Interacts with ALAS2 (By similarity). Mitochondrion Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily. nucleotide binding magnesium ion binding catalytic activity succinate-CoA ligase activity succinate-CoA ligase (ADP-forming) activity ATP binding mitochondrion tricarboxylic acid cycle succinyl-CoA metabolic process succinate metabolic process ligase activity succinate-CoA ligase complex myelin sheath metal ion binding uc007upy.1 uc007upy.2 uc007upy.3 
ENSMUST00000160520.2 Gm5766 ENSMUST00000160520.2 predicted gene 5766 (from RefSeq NR_003628.1) ENSMUST00000160520.1 NR_003628 uc007xzp.1 uc007xzp.2 uc007xzp.3 uc007xzp.1 uc007xzp.2 uc007xzp.3 
ENSMUST00000160534.2 Nat8f7 ENSMUST00000160534.2 N-acetyltransferase 8 (GCN5-related) family member 7, transcript variant 2 (from RefSeq NM_001411838.1) E0CYR6 ENSMUST00000160534.1 NM_001411838 NT8F7_MOUSE Nat8f7 uc029vxa.1 uc029vxa.2 uc029vxa.3 uc029vxa.4 Has histone acetyltransferase activity in vitro, with specificity for histone H4. Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; Membrane ; Multi-pass membrane protein Belongs to the camello family. histone acetyltransferase activity nucleus N-acetyltransferase activity H4 histone acetyltransferase activity membrane integral component of membrane histone acetylation transferase activity transferase activity, transferring acyl groups nuclear membrane histone H4 acetylation uc029vxa.1 uc029vxa.2 uc029vxa.3 uc029vxa.4 
ENSMUST00000160540.2 Gm15841 ENSMUST00000160540.2 Gm15841 (from geneSymbol) ENSMUST00000160540.1 uc287jha.1 uc287jha.2 uc287jha.1 uc287jha.2 
ENSMUST00000160544.2 Gm16117 ENSMUST00000160544.2 Gm16117 (from geneSymbol) ENSMUST00000160544.1 uc292dis.1 uc292dis.2 uc292dis.1 uc292dis.2 
ENSMUST00000160548.8 Ankmy1 ENSMUST00000160548.8 ankyrin repeat and MYND domain containing 1, transcript variant 2 (from RefSeq NM_001347091.1) Ankmy1 E0CYY3 E0CYY3_MOUSE ENSMUST00000160548.1 ENSMUST00000160548.2 ENSMUST00000160548.3 ENSMUST00000160548.4 ENSMUST00000160548.5 ENSMUST00000160548.6 ENSMUST00000160548.7 NM_001347091 uc007cbt.1 uc007cbt.2 metal ion binding uc007cbt.1 uc007cbt.2 
ENSMUST00000160562.2 D630014O11Rik ENSMUST00000160562.2 D630014O11Rik (from geneSymbol) AK085451 ENSMUST00000160562.1 uc008dnm.1 uc008dnm.2 uc008dnm.1 uc008dnm.2 
ENSMUST00000160564.2 Gm15851 ENSMUST00000160564.2 Gm15851 (from geneSymbol) ENSMUST00000160564.1 uc287lvk.1 uc287lvk.2 uc287lvk.1 uc287lvk.2 
ENSMUST00000160565.4 Ifi206 ENSMUST00000160565.4 interferon activated gene 206, transcript variant 2 (from RefSeq NM_001372437.1) ENSMUST00000160565.1 ENSMUST00000160565.2 ENSMUST00000160565.3 G3UZV2 G3UZV2_MOUSE Gm4955 Ifi206 NM_001372437 uc287oam.1 uc287oam.2 Belongs to the HIN-200 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding activation of innate immune response double-stranded DNA binding nucleus nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding uc287oam.1 uc287oam.2 
ENSMUST00000160568.2 Gm16306 ENSMUST00000160568.2 Gm16306 (from geneSymbol) ENSMUST00000160568.1 uc291lbv.1 uc291lbv.2 uc291lbv.1 uc291lbv.2 
ENSMUST00000160583.8 Ubn2 ENSMUST00000160583.8 ubinuclein 2 (from RefSeq NM_177185.4) ENSMUST00000160583.1 ENSMUST00000160583.2 ENSMUST00000160583.3 ENSMUST00000160583.4 ENSMUST00000160583.5 ENSMUST00000160583.6 ENSMUST00000160583.7 Kiaa2030 NM_177185 Q69Z27 Q80WC1 Q80ZZ9 Q8BQ40 Q8BRI2 UBN2_MOUSE uc009bke.1 uc009bke.2 uc009bke.3 uc009bke.4 Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80WC1-1; Sequence=Displayed; Name=2; IsoId=Q80WC1-2; Sequence=VSP_027026, VSP_027029; Name=3; IsoId=Q80WC1-3; Sequence=VSP_027023, VSP_027025, VSP_027027, VSP_027028; Name=4; IsoId=Q80WC1-4; Sequence=VSP_027024; Belongs to the ubinuclein family. Sequence=BAC31801.1; Type=Erroneous initiation; Evidence=; nucleus nucleoplasm uc009bke.1 uc009bke.2 uc009bke.3 uc009bke.4 
ENSMUST00000160597.8 Opa1 ENSMUST00000160597.8 OPA1, mitochondrial dynamin like GTPase, transcript variant 7 (from RefSeq NR_175360.1) A6H6Q3 ENSMUST00000160597.1 ENSMUST00000160597.2 ENSMUST00000160597.3 ENSMUST00000160597.4 ENSMUST00000160597.5 ENSMUST00000160597.6 ENSMUST00000160597.7 NR_175360 OPA1_MOUSE Opa1 P58281 Q3ULA5 Q8BKU7 Q8BLL3 Q8BM08 Q8R3J7 uc007ywf.1 uc007ywf.2 uc007ywf.3 uc007ywf.4 Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:11847212, PubMed:24616225, PubMed:26785494, PubMed:28746876). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (By similarity). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (PubMed:16839884, PubMed:16839885). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (PubMed:16839884, PubMed:16839885). Plays a role in mitochondrial genome maintenance (By similarity). [Dynamin-like 120 kDa protein, form S1]: Produced by cleavage at position S1 by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion. Isoforms that contain the alternative exon 4b (present in isoform 2, but not in isoform 1) are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5; Evidence=; Activated by guanine nucleotide exchange factor RCC1L. Oligomeric complex consisting of membrane-bound and soluble forms of OPA1 (PubMed:16839885). Interacts with CHCHD3 and IMMT; these interactions occur preferentially with soluble OPA1 forms (PubMed:21081504). Interacts with RCC1L; this interaction is direct (PubMed:28746876). Binds PARL (PubMed:16839884). Interacts with PRELID1 (By similarity). Mitochondrion inner membrane ingle-pass membrane protein Mitochondrion Mitochondrion membrane Note=Detected at contact sites between endoplasmic reticulum and mitochondrion membranes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P58281-1; Sequence=Displayed; Name=2; IsoId=P58281-2; Sequence=VSP_021037; Detected in brain (at protein level) (PubMed:11847212). Detected in brain, brain stem, heart, kidney, liver and skeletal muscle (PubMed:11847212). PARL-dependent proteolytic processing releases an antiapoptotic soluble form not required for mitochondrial fusion (PubMed:20038678, PubMed:24550258, PubMed:22433842). Cleaved by OMA1 at position S1 following stress conditions (PubMed:20038678, PubMed:24550258, PubMed:22433842). [Isoform 2]: Cleavage at position S2 is mediated by YME1L (PubMed:24616225, PubMed:26785494). Cleavage may occur in the sequence motif Leu-Gln-Gln-Gln-Ile-Gln (LQQQIQ) (By similarity). Embryonic fibroblasts that lack Opa1 show a defect in apoptosis in response to intrinsic signals. This defect can be complemented by a soluble form of Opa1 targeted to the mitochondrial intermembrane space. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Sequence=AAH25160.1; Type=Erroneous initiation; Evidence=; mitochondrial genome maintenance nucleotide binding mitochondrial fission neural tube closure GTPase activity protein binding GTP binding nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane mitochondrial inner membrane mitochondrial intermembrane space cytosol plasma membrane apoptotic process mitochondrion organization inner mitochondrial membrane organization visual perception microtubule binding mitochondrial fusion lipid binding positive regulation of mitochondrial fusion positive regulation of neuron maturation membrane integral component of membrane hydrolase activity kinase binding mitochondrial crista dendrite extrinsic component of mitochondrial inner membrane cytoplasmic vesicle mitochondrial membrane mitochondrial calcium uptake negative regulation of apoptotic process GTP metabolic process positive regulation of insulin receptor signaling pathway intracellular distribution of mitochondria response to stimulus protein oligomerization positive regulation of dendritic spine morphogenesis phosphatidic acid binding mitochondrion morphogenesis negative regulation of release of cytochrome c from mitochondria cellular senescence membrane tubulation positive regulation of dendrite development positive regulation of cellular response to insulin stimulus cardiolipin binding negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway uc007ywf.1 uc007ywf.2 uc007ywf.3 uc007ywf.4 
ENSMUST00000160605.2 Gm15684 ENSMUST00000160605.2 Gm15684 (from geneSymbol) AK085673 ENSMUST00000160605.1 uc292dmu.1 uc292dmu.2 uc292dmu.1 uc292dmu.2 
ENSMUST00000160606.2 Alms1-ps2 ENSMUST00000160606.2 ALMS1, centrosome and basal body associated, pseudogene 2 (from RefSeq NR_040440.2) ENSMUST00000160606.1 NR_040440 uc009cqe.1 uc009cqe.2 uc009cqe.3 uc009cqe.1 uc009cqe.2 uc009cqe.3 
ENSMUST00000160616.8 Tmem163 ENSMUST00000160616.8 transmembrane protein 163 (from RefSeq NM_028135.2) ENSMUST00000160616.1 ENSMUST00000160616.2 ENSMUST00000160616.3 ENSMUST00000160616.4 ENSMUST00000160616.5 ENSMUST00000160616.6 ENSMUST00000160616.7 NM_028135 Q8C8I2 Q8C996 Q9D0E0 Sv31 TM163_MOUSE uc011wqz.1 uc011wqz.2 uc011wqz.3 Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (By similarity). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (By similarity). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (By similarity). Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29352; Evidence=; Homodimer (By similarity). Interacts with MCOLN1 (PubMed:25130899). Interacts with SLC30A1, SLC30A2, SLC30A3 and SLC30A4 (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Glutamatergic synaptic vesicles. Widely expressed, with high expression in the brain, cerebellum, heart, lung and spleen (PubMed:31697912). In the brain, mainly expressed in the glutaminergic neuron subpopulations (PubMed:17623043). Belongs to the TMEM163 family. protein binding endosome plasma membrane biological_process zinc ion binding membrane integral component of membrane cell junction integral component of synaptic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle early endosome membrane synapse intracellular vesicle uc011wqz.1 uc011wqz.2 uc011wqz.3 
ENSMUST00000160626.4 Gm16050 ENSMUST00000160626.4 Gm16050 (from geneSymbol) ENSMUST00000160626.1 ENSMUST00000160626.2 ENSMUST00000160626.3 uc289hcy.1 uc289hcy.2 uc289hcy.1 uc289hcy.2 
ENSMUST00000160639.2 Slc14a1 ENSMUST00000160639.2 solute carrier family 14 (urea transporter), member 1, transcript variant 3 (from RefSeq NM_001171011.1) ENSMUST00000160639.1 NM_001171011 Q3U542 Q497G1 Q5RJG2 Q6PDP4 Q8VHL0 Q9CZX3 UT1_MOUSE uc008fse.1 uc008fse.2 uc008fse.3 Mediates the transport of urea driven by a concentration gradient across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (PubMed:11792714). Facilitates water transport in erythrocytes (PubMed:12133842). Reaction=urea(in) = urea(out); Xref=Rhea:RHEA:32799, ChEBI:CHEBI:16199; Evidence=; Homotrimer; each subunit contains a pore through which urea permeates (By similarity). Identified in a complex with STOM (By similarity). Cell membrane ulti-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Note=Restricted to the basolateral membrane in various portions of the urothelium. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VHL0-1; Sequence=Displayed; Name=2; IsoId=Q8VHL0-2; Sequence=VSP_041574; Expressed in brain, kidney, heart, liver, lung, skeletal muscle, spleen, testis, ureter and urinary bladder (at protein level). Along the gastrointestinal tract, detected in colon, jejunum and stomach (at protein level). In the kidney, expressed in some microvessels of the inner and outer medulla, but not all (at protein level). Not detected in the cortex (at protein level). Detected in the urothelium all along the urinary tract, including the papilla surface, the ureter, the bladder and the urethra (at protein level). In the brain, expressed at the border of the corpus callosum and striatum in astrocytic cellular processes surrounding blood microvessels (at protein level). Detected in erythrocytes (at protein level). Down-regulated by water deprivation in urinary bladder and ureter, but not in kidney medulla, colon, testis nor brain. N-glycosylated in red blood cells, as well as in most non- erythroid tissues, except in the gastrocnemius muscle and in the gastrointestinal tract, including liver, colon and stomach. Mutant mice exhibit grossly normal appearance, activity and behavior. Plasma sodium, potassium, chloride, bicarbonate and creatinine concentrations, as well as hematocrit, are similar to wild type animals. Urea permeability in erythrocytes is 45-fold lower than that from wild-type mice. Daily urine output is 1.5-fold greater and urine osmolarity is lower than in wild-type mice. After 24 hours of water deprivation, plasma urea concentration is 30% higher and urine urea concentration 35% lower in mutant mice than in wild-type animals. Mice lacking both Aqp1 and Slc14a1 are born at the expected Mendelian ratio, but do not thrive; half of them die within ten days after birth and none are alive after two weeks. Urine osmolality is somewhat lower than that observed with mice lacking Aqp1. Besides, erythrocyte water permeability is significantly lower than in mice lacking only Aqp1. Belongs to the urea transporter family. water transmembrane transporter activity nucleolus plasma membrane integral component of plasma membrane water transport urea transmembrane transporter activity urea channel activity urea transport membrane integral component of membrane basolateral plasma membrane intracellular membrane-bounded organelle urea transmembrane transport uc008fse.1 uc008fse.2 uc008fse.3 
ENSMUST00000160640.8 4933434E20Rik ENSMUST00000160640.8 RIKEN cDNA 4933434E20 gene, transcript variant 1 (from RefSeq NM_025762.4) CA043_MOUSE ENSMUST00000160640.1 ENSMUST00000160640.2 ENSMUST00000160640.3 ENSMUST00000160640.4 ENSMUST00000160640.5 ENSMUST00000160640.6 ENSMUST00000160640.7 NM_025762 Q3UBD8 Q8BII4 Q8BIP7 Q8R092 Q8R240 Q9CV59 Q9CYB6 uc008qbc.1 uc008qbc.2 uc008qbc.3 uc008qbc.4 uc008qbc.5 General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages. Membrane ; Single-pass membrane protein Golgi apparatus Mitochondrion Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R092-3; Sequence=Displayed; Name=2; IsoId=Q8R092-1; Sequence=VSP_014423, VSP_014424; Name=3; IsoId=Q8R092-2; Sequence=VSP_014422; N-terminal region is required for phagocytosis of Gram negative bacterium. in utero embryonic development molecular_function cellular_component membrane integral component of membrane uc008qbc.1 uc008qbc.2 uc008qbc.3 uc008qbc.4 uc008qbc.5 
ENSMUST00000160664.8 Ppp4r1 ENSMUST00000160664.8 protein phosphatase 4, regulatory subunit 1, transcript variant 4 (from RefSeq NR_152099.1) E9PX53 E9PX53_MOUSE ENSMUST00000160664.1 ENSMUST00000160664.2 ENSMUST00000160664.3 ENSMUST00000160664.4 ENSMUST00000160664.5 ENSMUST00000160664.6 ENSMUST00000160664.7 NR_152099 Ppp4r1 uc008dgj.1 uc008dgj.2 uc008dgj.3 uc008dgj.4 signal transduction protein phosphatase regulator activity protein phosphatase 4 complex regulation of phosphoprotein phosphatase activity regulation of catalytic activity uc008dgj.1 uc008dgj.2 uc008dgj.3 uc008dgj.4 
ENSMUST00000160679.9 C4a ENSMUST00000160679.9 complement C4A (Rodgers blood group), transcript variant 1, non-coding (from RefSeq NR_160726.1) ENSMUST00000160679.1 ENSMUST00000160679.2 ENSMUST00000160679.3 ENSMUST00000160679.4 ENSMUST00000160679.5 ENSMUST00000160679.6 ENSMUST00000160679.7 ENSMUST00000160679.8 NR_160726 uc289kgd.1 uc289kgd.2 uc289kgd.3 uc289kgd.1 uc289kgd.2 uc289kgd.3 
ENSMUST00000160694.2 Nes ENSMUST00000160694.2 Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division (By similarity). Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. (from UniProt Q6P5H2) A1E2I2 BC062893 ENSMUST00000160694.1 NEST_MOUSE Q6P5H2 Q80X00 Q8BPH7 Q9CV43 Q9R0C4 uc008ptm.1 uc008ptm.2 uc008ptm.3 Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division (By similarity). Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha- internexin, this protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P5H2-1; Sequence=Displayed; Name=2; IsoId=Q6P5H2-2; Sequence=VSP_024923; Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity). Embryonic lethality with the neuroepithelium of developing neural tube exhibiting low numbers of neural stem cells and high levels of apoptosis. No effect on cytoskeletal integrity. Belongs to the intermediate filament family. G2/M transition of mitotic cell cycle protein binding cytoplasm intermediate filament multicellular organism development nervous system development brain development intermediate filament binding positive regulation of intermediate filament depolymerization embryonic camera-type eye development CCR5 chemokine receptor binding negative regulation of protein binding negative regulation of catalytic activity negative regulation of neuron apoptotic process intermediate filament cytoskeleton cell projection morphogenesis stem cell proliferation positive regulation of neural precursor cell proliferation uc008ptm.1 uc008ptm.2 uc008ptm.3 
ENSMUST00000160708.8 Stxbp2 ENSMUST00000160708.8 syntaxin binding protein 2, transcript variant 2 (from RefSeq NM_011503.5) ENSMUST00000160708.1 ENSMUST00000160708.2 ENSMUST00000160708.3 ENSMUST00000160708.4 ENSMUST00000160708.5 ENSMUST00000160708.6 ENSMUST00000160708.7 NM_011503 Q64324 STXB2_MOUSE Unc18b uc009kse.1 uc009kse.2 uc009kse.3 Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells (By similarity). Interacts with STX1A, STX2 and STX3. Interacts with STX11. Expressed in testis, intestine, kidney, rat adipose tissue and 3T3-L1 cells. Belongs to the STXBP/unc-18/SEC1 family. leukocyte mediated cytotoxicity protein binding cytoplasm cytosol plasma membrane exocytosis vesicle docking involved in exocytosis protein transport vesicle-mediated transport apical plasma membrane syntaxin-1 binding syntaxin binding lamellipodium syntaxin-3 binding macromolecular complex specific granule azurophil granule zymogen granule membrane regulation of mast cell degranulation positive regulation of mast cell degranulation neutrophil degranulation cytolytic granule phagocytic vesicle tertiary granule cellular response to interferon-gamma secretory granule uc009kse.1 uc009kse.2 uc009kse.3 
ENSMUST00000160719.8 Mfap3l ENSMUST00000160719.8 microfibrillar-associated protein 3-like, transcript variant 1 (from RefSeq NM_027756.5) ENSMUST00000160719.1 ENSMUST00000160719.2 ENSMUST00000160719.3 ENSMUST00000160719.4 ENSMUST00000160719.5 ENSMUST00000160719.6 ENSMUST00000160719.7 Kiaa0626 MFA3L_MOUSE NM_027756 Q80TV6 Q8BJA9 Q9D3X9 uc009ltf.1 uc009ltf.2 uc009ltf.3 uc009ltf.4 uc009ltf.5 May participate in the nuclear signaling of EGFR and MAPK1/ERK2. Cell membrane ; Single-pass type I membrane protein Nucleus Cytoplasm Note=Mainly localized in the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D3X9-1; Sequence=Displayed; Name=2; IsoId=Q9D3X9-2; Sequence=VSP_014096; A protein kinase activity has been reported however PROSITE, Pfam do not detect a protein kinase domain. Its enzyme activity is therefore unsure. molecular_function nucleus cytoplasm plasma membrane biological_process membrane integral component of membrane uc009ltf.1 uc009ltf.2 uc009ltf.3 uc009ltf.4 uc009ltf.5 
ENSMUST00000160722.8 Iftap ENSMUST00000160722.8 Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. (from UniProt Q9CQI4) A2AVN5 A2AVN6 DQ112092 ENSMUST00000160722.1 ENSMUST00000160722.2 ENSMUST00000160722.3 ENSMUST00000160722.4 ENSMUST00000160722.5 ENSMUST00000160722.6 ENSMUST00000160722.7 IFTAP_MOUSE Nwc Q8C2H0 Q8R186 Q9CQI4 uc289ysz.1 uc289ysz.2 Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. Interacts with IFT122; the interaction associates IFTAP with IFT-A complex. Ubiquitous. Mutant mice show no obvious anatomical abnormalities associated with ciliary dysfunction. Sequence=CAM20885.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM20886.1; Type=Erroneous gene model prediction; Evidence=; cytosol spermatogenesis acrosome reaction fertilization 9+0 non-motile cilium uc289ysz.1 uc289ysz.2 
ENSMUST00000160726.4 Fbll1 ENSMUST00000160726.4 fibrillarin-like 1 (from RefSeq NM_001004147.3) ENSMUST00000160726.1 ENSMUST00000160726.2 ENSMUST00000160726.3 FBLL1_MOUSE NM_001004147 Q80WS3 uc007ilg.1 uc007ilg.2 uc007ilg.3 S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). Nucleus, nucleolus. Note=Fibrillar region of the nucleolus. By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA). Belongs to the methyltransferase superfamily. Fibrillarin family. box C/D snoRNA 3'-end processing fibrillar center blastocyst hatching RNA binding nucleus nucleolus rRNA processing methyltransferase activity rRNA methyltransferase activity Cajal body transferase activity rRNA methylation box C/D snoRNP complex small-subunit processome methylation histone glutamine methylation histone-glutamine methyltransferase activity uc007ilg.1 uc007ilg.2 uc007ilg.3 
ENSMUST00000160756.2 Gm15939 ENSMUST00000160756.2 predicted gene 15939 (from RefSeq NR_152723.1) ENSMUST00000160756.1 NR_152723 uc287qky.1 uc287qky.2 uc287qky.1 uc287qky.2 
ENSMUST00000160764.3 Gm21970 ENSMUST00000160764.3 Gm21970 (from geneSymbol) AK160991 ENSMUST00000160764.1 ENSMUST00000160764.2 F6XX07 F6XX07_MOUSE Gm21970 Ifnar2 uc289gac.1 uc289gac.2 uc289gac.3 cytokine receptor activity interleukin-10 receptor activity plasma membrane cytokine-mediated signaling pathway uc289gac.1 uc289gac.2 uc289gac.3 
ENSMUST00000160777.8 Oprk1 ENSMUST00000160777.8 opioid receptor, kappa 1, transcript variant 2 (from RefSeq NM_011011.2) ENSMUST00000160777.1 ENSMUST00000160777.2 ENSMUST00000160777.3 ENSMUST00000160777.4 ENSMUST00000160777.5 ENSMUST00000160777.6 ENSMUST00000160777.7 NM_011011 Oprk1 Q14AL5 Q14AL5_MOUSE uc007afo.1 uc007afo.2 uc007afo.3 uc007afo.4 This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]. G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. Interacts with NHERF1. Interacts with GABARAPL1. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity opioid receptor activity nucleus cytosol plasma membrane integral component of plasma membrane immune response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway response to radiation membrane integral component of membrane integral component of synaptic vesicle membrane dendrite adenylate cyclase-inhibiting opioid receptor signaling pathway response to insulin positive regulation of dopamine secretion receptor serine/threonine kinase binding negative regulation of luteinizing hormone secretion opioid receptor signaling pathway dynorphin receptor activity positive regulation of locomotion response to cocaine maternal behavior eating behavior neuronal cell body perikaryon response to morphine response to estrogen axon terminus estrous cycle synapse response to ethanol behavioral response to cocaine sensory perception of temperature stimulus defense response to virus regulation of sensory perception of pain cellular response to lipopolysaccharide cellular response to glucose stimulus integral component of postsynaptic membrane integral component of presynaptic membrane positive regulation of p38MAPK cascade positive regulation of potassium ion transmembrane transport response to acrylamide positive regulation of eating behavior conditioned place preference uc007afo.1 uc007afo.2 uc007afo.3 uc007afo.4 
ENSMUST00000160792.8 Sp140l1 ENSMUST00000160792.8 Sp140 nuclear body protein like 1 (from RefSeq NM_213615.2) A530032D15Rik E9PV05 E9PV05_MOUSE ENSMUST00000160792.1 ENSMUST00000160792.2 ENSMUST00000160792.3 ENSMUST00000160792.4 ENSMUST00000160792.5 ENSMUST00000160792.6 ENSMUST00000160792.7 NM_213615 Sp140l1 uc007btj.1 uc007btj.2 uc007btj.3 molecular_function cellular_component nucleus biological_process nuclear body uc007btj.1 uc007btj.2 uc007btj.3 
ENSMUST00000160800.9 Nrxn1 ENSMUST00000160800.9 neurexin I, transcript variant 2 (from RefSeq NM_177284.3) E0CY11 E0CY11_MOUSE ENSMUST00000160800.1 ENSMUST00000160800.2 ENSMUST00000160800.3 ENSMUST00000160800.4 ENSMUST00000160800.5 ENSMUST00000160800.6 ENSMUST00000160800.7 ENSMUST00000160800.8 NM_177284 Nrxn1 uc012ayq.1 uc012ayq.2 uc012ayq.3 This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC079893.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## Presynaptic cell membrane ; Single-pass type I membrane protein Belongs to the neurexin family. Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc012ayq.1 uc012ayq.2 uc012ayq.3 
ENSMUST00000160801.8 Wdr41 ENSMUST00000160801.8 WD repeat domain 41 (from RefSeq NM_172590.4) ENSMUST00000160801.1 ENSMUST00000160801.2 ENSMUST00000160801.3 ENSMUST00000160801.4 ENSMUST00000160801.5 ENSMUST00000160801.6 ENSMUST00000160801.7 NM_172590 Q3UDP0 Q8C4F1 Q8C8K5 WDR41_MOUSE Wdr41 uc033gmu.1 uc033gmu.2 uc033gmu.3 This gene encodes a protein of unknown function, but which contains a WD40 domain consisting of six WD40 repeats. The WD40 domain is one of the most abundant protein domains in eukaryotes, and is found in proteins with widely varying cellular functions. However, proteins with this domain often provide a rigid scaffold for protein-protein interactions. [provided by RefSeq, Aug 2012]. CCDS Note: This CCDS ID was updated to correctly position the short fifth coding exon, which was mis-positioned in version 1. ##Evidence-Data-START## Transcript exon combination :: AK149993.1, SRR1660815.225104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (By similarity). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity. Component of the C9orf72-SMCR8 complex, at least composed of C9orf72, SMCR8 and WDR41. The complex is formed of two protomers, each individually consisting of one molecule each of C9orf72, SMCR8 and WDR41 (By similarity). The protomers homodimerize via an interaction between C9orf72 (via C-terminus) and SMCR8 (via N-terminus) (By similarity). Within each protomer SMCR8 (via DENN domain) acts as a bridging protein between WDR41 (via C-terminus and N-terminus) and C9orf72 (via C-terminus) (By similarity). The C9orf72-SMCR8 complex associates with the ULK1/ATG1 kinase complex. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UDP0-1; Sequence=Displayed; Name=2; IsoId=Q3UDP0-2; Sequence=VSP_016182, VSP_016183; cytoplasm autophagy regulation of autophagy Rab guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor complex ATG1/ULK1 kinase complex uc033gmu.1 uc033gmu.2 uc033gmu.3 
ENSMUST00000160818.2 6330549D23Rik ENSMUST00000160818.2 6330549D23Rik (from geneSymbol) AK088233 ENSMUST00000160818.1 uc290hus.1 uc290hus.2 uc290hus.1 uc290hus.2 
ENSMUST00000160822.3 A130010J15Rik ENSMUST00000160822.3 Belongs to the UPF0739 family. (from UniProt Q9DAE8) BC055955 CA074_MOUSE ENSMUST00000160822.1 ENSMUST00000160822.2 Q9DAE8 uc007eea.1 uc007eea.2 uc007eea.3 uc007eea.4 Belongs to the UPF0739 family. molecular_function cellular_component biological_process uc007eea.1 uc007eea.2 uc007eea.3 uc007eea.4 
ENSMUST00000160826.2 Commd1b ENSMUST00000160826.2 Commd1b (from geneSymbol) BC098462 Commd1 Commd1b ENSMUST00000160826.1 F7BCN0 F7BCN0_MOUSE uc033fub.1 uc033fub.2 uc033fub.3 endosome positive regulation of protein ubiquitination regulation of proteasomal ubiquitin-dependent protein catabolic process copper ion homeostasis negative regulation of sodium ion transmembrane transport negative regulation of protein localization to cell surface uc033fub.1 uc033fub.2 uc033fub.3 
ENSMUST00000160834.8 Nbeal1 ENSMUST00000160834.8 neurobeachin like 1 (from RefSeq NM_173444.2) E9PYP2 E9PYP2_MOUSE ENSMUST00000160834.1 ENSMUST00000160834.2 ENSMUST00000160834.3 ENSMUST00000160834.4 ENSMUST00000160834.5 ENSMUST00000160834.6 ENSMUST00000160834.7 NM_173444 Nbeal1 uc007bej.1 uc007bej.2 uc007bej.3 uc007bej.1 uc007bej.2 uc007bej.3 
ENSMUST00000160835.9 Pip4p1 ENSMUST00000160835.9 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1, transcript variant 1 (from RefSeq NM_001033271.5) ENSMUST00000160835.1 ENSMUST00000160835.2 ENSMUST00000160835.3 ENSMUST00000160835.4 ENSMUST00000160835.5 ENSMUST00000160835.6 ENSMUST00000160835.7 ENSMUST00000160835.8 NM_001033271 PP4P1_MOUSE Pip4p1 Q3TWL2 Tmem55b uc007tma.1 uc007tma.2 uc007tma.3 uc007tma.4 Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:25674, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57795, ChEBI:CHEBI:58456; EC=3.1.3.78; Evidence=; Interacts (via transmembrane domain) with ATP6V0D1 (PubMed:29644770). Interacts with LAMTOR1, RRAGA and RRAGC (PubMed:29644770). Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein protein binding lysosome lysosomal membrane endosome plasma membrane response to sterol depletion cholesterol metabolic process membrane integral component of membrane hydrolase activity phagocytic vesicle membrane cytoplasmic vesicle late endosome membrane lysosome localization phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity phosphatidylinositol dephosphorylation proton-transporting V-type ATPase complex assembly positive regulation of TORC1 signaling uc007tma.1 uc007tma.2 uc007tma.3 uc007tma.4 
ENSMUST00000160847.2 Hgd ENSMUST00000160847.2 homogentisate 1, 2-dioxygenase, transcript variant 1 (from RefSeq NM_013547.3) Aku ENSMUST00000160847.1 HGD_MOUSE Hgo NM_013547 O09173 Q7TPP2 uc007zeg.1 uc007zeg.2 uc007zeg.3 uc007zeg.4 Catalyzes the conversion of homogentisate to maleylacetoacetate. Reaction=homogentisate + O2 = 4-maleylacetoacetate + H(+); Xref=Rhea:RHEA:15449, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16169, ChEBI:CHEBI:17105; EC=1.13.11.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15450; Evidence=; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Kinetic parameters: KM=188 uM for homogentisate ; pH dependence: Optimum pH is 6.1. ; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. Homohexamer arranged as a dimer of trimers. Note=Defects in Hgd are the cause of alkaptonuria (aku). Aku is an autosomal recessive error of metabolism which is characterized by an increase in the level of homogentisic acid. Belongs to the homogentisate dioxygenase family. homogentisate 1,2-dioxygenase activity cellular amino acid metabolic process L-phenylalanine catabolic process tyrosine metabolic process tyrosine catabolic process oxidoreductase activity identical protein binding metal ion binding dioxygenase activity oxidation-reduction process uc007zeg.1 uc007zeg.2 uc007zeg.3 uc007zeg.4 
ENSMUST00000160852.8 Gm50387 ENSMUST00000160852.8 Gm50387 (from geneSymbol) AB012727 C184 ENSMUST00000160852.1 ENSMUST00000160852.2 ENSMUST00000160852.3 ENSMUST00000160852.4 ENSMUST00000160852.5 ENSMUST00000160852.6 ENSMUST00000160852.7 Q545N1 Q545N1_MOUSE uc289qhu.1 uc289qhu.2 uc289qhu.1 uc289qhu.2 
ENSMUST00000160853.8 Maf1 ENSMUST00000160853.8 MAF1 homolog, negative regulator of RNA polymerase III, transcript variant 3 (from RefSeq NM_001164608.1) ENSMUST00000160853.1 ENSMUST00000160853.2 ENSMUST00000160853.3 ENSMUST00000160853.4 ENSMUST00000160853.5 ENSMUST00000160853.6 ENSMUST00000160853.7 MAF1_MOUSE NM_001164608 Q3U4U3 Q91W84 Q9D0U6 uc007wjx.1 uc007wjx.2 uc007wjx.3 uc007wjx.4 Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (By similarity). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (PubMed:30110641). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB. When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout. Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (By similarity). Interacts with TFIIIB subunits BRF1 and BRF2. Interacts with Pol III subunit POLR3F. Interacts with TFIIIC subunit GTF3C1. Nucleus Cytoplasm Phosphorylated at Ser-60, Ser-68 and Ser-75; the major sites of phosphorylation. Nuclear accumulation correlates with a concomitant dephosphorylation. Phosphorylation may attenuate its RNA polymerase III-repressive function (By similarity). Sumoylated with SUMO1 and SUMO2, mainly on Lys-35. Desumoylated by SENP1. SUMOylation promotes the ability of MAF1 to repress transcription and suppress colony formation (By similarity). MAF1 deficient mice display a decreased metabolic efficiency. Constitutive high levels of Pol III transcription reprogram central metabolic pathways and waste metabolic energy through a futile RNA cycle (PubMed:30429315, PubMed:25934505). MAF1 down-regulation also alters the expression of genes involved in lipid and sugar metabolism (PubMed:30110641). Belongs to the MAF1 family. RNA polymerase III core binding RNA polymerase III type 1 promoter DNA binding RNA polymerase III type 2 promoter DNA binding RNA polymerase III type 3 promoter DNA binding nucleus nucleolus cytoplasm cytosol plasma membrane negative regulation of transcription from RNA polymerase III promoter axon dendrite intracellular membrane-bounded organelle perinuclear region of cytoplasm GABA receptor binding inhibitory synapse uc007wjx.1 uc007wjx.2 uc007wjx.3 uc007wjx.4 
ENSMUST00000160860.9 Klhl3 ENSMUST00000160860.9 kelch-like 3, transcript variant 3 (from RefSeq NM_001368868.2) E0CZ16 ENSMUST00000160860.1 ENSMUST00000160860.2 ENSMUST00000160860.3 ENSMUST00000160860.4 ENSMUST00000160860.5 ENSMUST00000160860.6 ENSMUST00000160860.7 ENSMUST00000160860.8 F7A5U9 I6L891 KLHL3_MOUSE Klhl3 NM_001368868 uc288nfb.1 uc288nfb.2 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:24821705, PubMed:25831548, PubMed:28052936, PubMed:35621709). The BCR(KLHL3) complex acts by mediating ubiquitination and degradation of WNK1 and WNK4, two activators of Na- Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney, thereby regulating NaCl reabsorption (PubMed:24821705, PubMed:28052936, PubMed:35621709). The BCR(KLHL3) complex also mediates ubiquitination of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney, leading to its degradation (PubMed:25831548). Protein modification; protein ubiquitination. Homodimer (By similarity). Component of the BCR(KLHL3) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL3 and RBX1 (By similarity). Interacts with CLDN8 (PubMed:25831548). Cytoplasm, cytosol Cytoplasm, cytoskeleton Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E0CZ16-1; Sequence=Displayed; Name=2; IsoId=E0CZ16-2; Sequence=VSP_053297; Present at high level in brain and kidney (at protein level) (PubMed:28052936). Weakly expressed in other tissues (PubMed:28052936). In kidney, predominantly localizes to the distal convoluted tubule (DCT) and collecting duct, with apical localization in the DCT (at protein level) (PubMed:22266938, PubMed:22406640). Phosphorylation at Ser-433 by PKA or PKC decreases the interaction with WNK1 and WNK4, leading to inhibit their degradation by the BCR(KLHL3) complex (By similarity). Phosphorylated at Ser-433 by PKC in response to angiotensin II signaling, decreasing ability to promote degradation of WNK1 and WNK4, leading to activation of Na-Cl cotransporter SLC12A3/NCC (PubMed:25313067). Phosphorylation at Ser-433 is increased by insulin (By similarity). Dephosphorylated at Ser-433 by calcineurin PPP3CA, promoting degradation of WNK1 and WNK4 (By similarity). Mice display pseudohypoaldosteronism type II (PHA2)-like phenotype, such as salt-sensitive hypertension (PubMed:28052936). In kidney, increased level of Wnk1 and Wnk4 kinases is observed, while Wnk1 and Wnk4 levels are unchanged in other tissues (PubMed:28052936). Belongs to the KLHL3 family. actin binding catalytic activity cytoplasm cytosol cytoskeleton ubiquitin-dependent protein catabolic process protein ubiquitination Cul3-RING ubiquitin ligase complex ion homeostasis renal sodium ion absorption protein K48-linked ubiquitination distal tubule morphogenesis uc288nfb.1 uc288nfb.2 
ENSMUST00000160884.9 Kcnab2 ENSMUST00000160884.9 potassium voltage-gated channel, shaker-related subfamily, beta member 2, transcript variant 2 (from RefSeq NM_010598.5) Ckbeta2 ENSMUST00000160884.1 ENSMUST00000160884.2 ENSMUST00000160884.3 ENSMUST00000160884.4 ENSMUST00000160884.5 ENSMUST00000160884.6 ENSMUST00000160884.7 ENSMUST00000160884.8 I2rf5 KCAB2_MOUSE Kcnb3 NM_010598 P62482 P97381 Q60942 Q64284 uc008wan.1 uc008wan.2 uc008wan.3 uc008wan.4 uc008wan.5 Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:8576199). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (PubMed:11825900, PubMed:21209188). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:8576199). Modulates the functional properties of KCNA4 (By similarity). Modulates the functional properties of KCNA5 (PubMed:8576199). Enhances KCNB2 channel activity (PubMed:8824288). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10- phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4- nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity). Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (By similarity). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity). Interacts with KCNA1 (By similarity). Interacts with KCNA2 (By similarity). Interacts with KCNA4 and KCND3 (By similarity). Interacts (in unphosphorylated form) with MAPRE1 (By similarity). Interacts with KCNA5 (PubMed:8576199, PubMed:8824288). Interacts with KCNB2 (PubMed:8824288). Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). Cytoplasm Membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, axon Synapse, synaptosome Cytoplasm, cytoskeleton Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated. Detected in brain (PubMed:21357749). Detected at basket cell terminals in cerebellum and in the juxtaparanodal region of nodes of Ranvier (at protein level) (PubMed:11825900, PubMed:26269648). Strongest expression in brain and eye. Highest levels in brain detected in brainstem and diencephalon. Strong expression also detected in lung and heart. Moderate expression in kidney, T-lymphocytes and skeletal muscle. Not detected prior to birth, low levels of expression detected from postnatal days 1 to 7. Expression reaches adult levels by postnatal day 21. In contrast to KCNAB1, the shorter N-terminal domain of KCNAB2 cannot mediate closure of delayed rectifier potassium channels by physically obstructing the pore. Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1. Mutant mice are born at the expected Mendelian rate and are fertile, but exhibit occasional seizures and have a median lifespan of 255 days, which is much shorter than the 400 days typically observed for heterozygotes (PubMed:11825900). The reduction in lifespan depends strongly on the genetic background; median survival is 138 days for B6 mice, 255 days for B6/129 mice and over 400 days for 129/SvEv mice (PubMed:15720404). Mice exhibit whole body tremors after swimming in cold water, which is not observed in wild-type (PubMed:11825900). The whole body tremors observed after swimming in cold water differ between mouse strains; the observed differences are largely due to differences in the decrease of the core body temperature (PubMed:15720404). Mice lacking both KCNAB1 and KCNAB2 have a median survival of 114 days instead of the 255 days observed for mice lacking only KCNAB2, but show no aggravation of the whole body tremors observed after swimming in cold water (PubMed:15720404). Mice lacking KCNAB2 show subtle deficits in associative learning and aberrant excitability of neurons from the lateral amygdala (PubMed:21209188). Belongs to the shaker potassium channel beta subunit family. hematopoietic progenitor cell differentiation aldo-keto reductase (NADP) activity voltage-gated ion channel activity voltage-gated potassium channel activity protein binding cytoplasm cytosol cytoskeleton plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex postsynaptic density potassium channel regulator activity membrane integral component of membrane oxidoreductase activity cell junction axon extrinsic component of cytoplasmic side of plasma membrane ion transmembrane transport potassium channel complex regulation of ion transmembrane transport cell projection neuron projection axon terminus juxtaparanode region of axon ion channel binding synapse neuromuscular process protein heterooligomerization oxidation-reduction process NADPH oxidation potassium ion transmembrane transport regulation of potassium ion transmembrane transport pinceau fiber regulation of protein localization to cell surface microtubule uc008wan.1 uc008wan.2 uc008wan.3 uc008wan.4 uc008wan.5 
ENSMUST00000160918.8 Thnsl2 ENSMUST00000160918.8 threonine synthase-like 2 (bacterial), transcript variant 2 (from RefSeq NM_001033929.2) ENSMUST00000160918.1 ENSMUST00000160918.2 ENSMUST00000160918.3 ENSMUST00000160918.4 ENSMUST00000160918.5 ENSMUST00000160918.6 ENSMUST00000160918.7 NM_001033929 Q80W22 Q8R135 THNS2_MOUSE uc009cgg.1 uc009cgg.2 uc009cgg.3 uc009cgg.4 Acts as a catabolic phospho-lyase on both gamma- and beta- phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate. Also degrades O-phospho- homoserine (PHS), but this is not its physiological substrate. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Belongs to the threonine synthase family. threonine synthase activity serine family amino acid catabolic process threonine biosynthetic process dephosphorylation lyase activity pyridoxal phosphate binding 2-oxobutyrate biosynthetic process serine binding uc009cgg.1 uc009cgg.2 uc009cgg.3 uc009cgg.4 
ENSMUST00000160932.4 Airn ENSMUST00000160932.4 antisense Igf2r RNA, transcript variant 3 (from RefSeq NR_027773.1) ENSMUST00000160932.1 ENSMUST00000160932.2 ENSMUST00000160932.3 NR_027773 uc008alb.1 uc008alb.2 uc008alb.3 uc008alb.4 uc008alb.5 This gene is a paternally expressed imprinted gene. Alternatively spliced transcript variants have been produced from this gene and they are all long non-coding RNAs. These variants share the same 5' exon, and their 3' exons are divergent. The 5' exon overlaps the intron 2 of the Igf2r gene on the opposite strand. The Igf2r intron 2 contains a CpG island, which is a promoter and drives the expression of this gene. This gene is responsible for silencing Igf2r, and the flanking Slc22a2 and Slc22a3 genes in the imprinted gene cluster. It regulates transcription of these genes through epigenetic modifications. [provided by RefSeq, Jan 2013]. uc008alb.1 uc008alb.2 uc008alb.3 uc008alb.4 uc008alb.5 
ENSMUST00000160937.9 Dlx6 ENSMUST00000160937.9 Nucleus (from UniProt P70397) A0AUM1 A5HKN2 DLX6_MOUSE EF535989 ENSMUST00000160937.1 ENSMUST00000160937.2 ENSMUST00000160937.3 ENSMUST00000160937.4 ENSMUST00000160937.5 ENSMUST00000160937.6 ENSMUST00000160937.7 ENSMUST00000160937.8 P70397 uc291ckw.1 uc291ckw.2 Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70397-1; Sequence=Displayed; Name=2; IsoId=P70397-2; Sequence=VSP_040733; Belongs to the distal-less homeobox family. RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development cell differentiation embryonic limb morphogenesis epithelial cell differentiation inner ear morphogenesis sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter anatomical structure formation involved in morphogenesis positive regulation of epithelial cell proliferation palate development head development uc291ckw.1 uc291ckw.2 
ENSMUST00000160938.4 Gm16006 ENSMUST00000160938.4 predicted gene 16006 (from RefSeq NR_188866.1) ENSMUST00000160938.1 ENSMUST00000160938.2 ENSMUST00000160938.3 NR_188866 uc288ydb.1 uc288ydb.2 uc288ydb.3 uc288ydb.4 uc288ydb.1 uc288ydb.2 uc288ydb.3 uc288ydb.4 
ENSMUST00000160940.2 Tecta ENSMUST00000160940.2 tectorin alpha, transcript variant 2 (from RefSeq NM_001324548.2) E9QNR3 ENSMUST00000160940.1 NM_001324548 O08523 TECTA_MOUSE uc012grn.1 uc012grn.2 uc012grn.3 uc012grn.4 One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. May form homomeric filament after self-association or heteromeric filament after association with beta-tectorin (Probable). Interacts with CEACAM16 (PubMed:25080593). Cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side Secreted, extracellular space, extracellular matrix Note=Found in the non-collagenous matrix of the tectorial membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O08523-1; Sequence=Displayed; Name=2; IsoId=O08523-2; Sequence=VSP_010557; Cochlea-specific. Zona pellucida domain may enable to form filaments. 3 products of tectorin seem to exist: HMM, MMM and LMM. They may be generated by active processing or the result of proteolysis occurring between intrachain disulfide bonds. The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment. extracellular matrix structural constituent protein binding extracellular region plasma membrane cell-matrix adhesion sensory perception of sound membrane extracellular matrix anchored component of membrane uc012grn.1 uc012grn.2 uc012grn.3 uc012grn.4 
ENSMUST00000160942.8 Fam83a ENSMUST00000160942.8 family with sequence similarity 83, member A (from RefSeq NM_173862.2) ENSMUST00000160942.1 ENSMUST00000160942.2 ENSMUST00000160942.3 ENSMUST00000160942.4 ENSMUST00000160942.5 ENSMUST00000160942.6 ENSMUST00000160942.7 FA83A_MOUSE Fam83a NM_173862 Q8K2P2 uc011zta.1 uc011zta.2 uc011zta.3 uc011zta.4 Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. Interacts with the regulatory subunit p85 of PI3-kinase; increased by EGFR activation. Interacts with RAF1; increased by EGFR activation it activates RAF1. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2P2-1; Sequence=Displayed; Name=2; IsoId=Q8K2P2-2; Sequence=VSP_025192, VSP_025193; Phosphorylated upon EGFR activation. Belongs to the FAM83 family. cellular_component cytoplasm epidermal growth factor receptor signaling pathway cell proliferation protein kinase binding phosphatidylinositol 3-kinase regulatory subunit binding uc011zta.1 uc011zta.2 uc011zta.3 uc011zta.4 
ENSMUST00000160950.3 Gm20649 ENSMUST00000160950.3 Gm20649 (from geneSymbol) AK050237 ENSMUST00000160950.1 ENSMUST00000160950.2 uc009qrg.1 uc009qrg.2 uc009qrg.3 uc009qrg.4 uc009qrg.5 uc009qrg.1 uc009qrg.2 uc009qrg.3 uc009qrg.4 uc009qrg.5 
ENSMUST00000160953.8 Sphkap ENSMUST00000160953.8 SPHK1 interactor, AKAP domain containing, transcript variant 2 (from RefSeq NM_172430.5) E9PUC4 E9PUC4_MOUSE ENSMUST00000160953.1 ENSMUST00000160953.2 ENSMUST00000160953.3 ENSMUST00000160953.4 ENSMUST00000160953.5 ENSMUST00000160953.6 ENSMUST00000160953.7 NM_172430 Sphkap uc007bsq.1 uc007bsq.2 uc007bsq.3 uc007bsq.4 Belongs to the AKAP110 family. protein kinase A binding uc007bsq.1 uc007bsq.2 uc007bsq.3 uc007bsq.4 
ENSMUST00000160954.2 Gm16339 ENSMUST00000160954.2 Gm16339 (from geneSymbol) ENSMUST00000160954.1 uc288iti.1 uc288iti.2 uc288iti.1 uc288iti.2 
ENSMUST00000160959.8 Commd2 ENSMUST00000160959.8 COMM domain containing 2 (from RefSeq NM_175095.4) COMD2_MOUSE ENSMUST00000160959.1 ENSMUST00000160959.2 ENSMUST00000160959.3 ENSMUST00000160959.4 ENSMUST00000160959.5 ENSMUST00000160959.6 ENSMUST00000160959.7 NM_175095 Q8BJI3 Q8BXC6 uc008phd.1 uc008phd.2 uc008phd.3 May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4B, CUL5, CUL7. Cytoplasm molecular_function cellular_component cytoplasm biological_process uc008phd.1 uc008phd.2 uc008phd.3 
ENSMUST00000160960.2 Galnt6os ENSMUST00000160960.2 Galnt6os (from geneSymbol) AK028111 ENSMUST00000160960.1 uc007xsc.1 uc007xsc.2 uc007xsc.3 uc007xsc.1 uc007xsc.2 uc007xsc.3 
ENSMUST00000160967.2 Gm16567 ENSMUST00000160967.2 Gm16567 (from geneSymbol) ENSMUST00000160967.1 uc291ita.1 uc291ita.2 uc291ita.1 uc291ita.2 
ENSMUST00000160987.8 Srgn ENSMUST00000160987.8 serglycin, transcript variant 2 (from RefSeq NM_001358965.1) ENSMUST00000160987.1 ENSMUST00000160987.2 ENSMUST00000160987.3 ENSMUST00000160987.4 ENSMUST00000160987.5 ENSMUST00000160987.6 ENSMUST00000160987.7 NM_001358965 P13609 Prg Prg1 Q3TZD4 Q8C2U2 SRGN_MOUSE uc287rqa.1 uc287rqa.2 Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule- mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization. Binds to activated CD44 and to GZMB. Cytoplasmic granule Cytolytic granule Secreted, extracellular space Golgi apparatus Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T-lymphocytes from where it is secreted upon cell activation (PubMed:16046402). Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation (By similarity). By phorbol myristate acetate in T-lymphocytes. This induction is not inhibited by cyclosporine. O-glycosylated; contains chondroitin sulfate and heparan sulfate. Mice develop normally and are fertile but display mast cell granule and T-lymphocyte secretory granule defects. Granules are more amorphous than in the wild-type and show a less defined dense core formation. There is a lack of mast cell-specific protease activity although mRNAs for a variety of proteases are detected and storage of granzyme B is affected in T-lymphocytes. Neutrophil granules display a lack of neutrophil elastase and processing of MMP2 is abrogated. Macrophages show no major morphological defects. Belongs to the serglycin family. protein binding collagen binding extracellular region extracellular space Golgi apparatus apoptotic process granzyme-mediated apoptotic signaling pathway protein processing negative regulation of bone mineralization biomineral tissue development mast cell secretory granule organization T cell secretory granule organization maintenance of protease location in mast cell secretory granule maintenance of granzyme B location in T cell secretory granule zymogen granule mast cell granule negative regulation of cytokine secretion modulation of synaptic transmission glutamatergic synapse postsynaptic specialization, intracellular component Golgi membrane uc287rqa.1 uc287rqa.2 
ENSMUST00000161002.8 Ecel1 ENSMUST00000161002.8 endothelin converting enzyme-like 1, transcript variant 2 (from RefSeq NM_021306.4) Dine ECEL1_MOUSE ENSMUST00000161002.1 ENSMUST00000161002.2 ENSMUST00000161002.3 ENSMUST00000161002.4 ENSMUST00000161002.5 ENSMUST00000161002.6 ENSMUST00000161002.7 NM_021306 Q6PFG4 Q9JMI0 Xce uc007bwc.1 uc007bwc.2 uc007bwc.3 uc007bwc.4 May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion. ; Membrane ; Single-pass type II membrane protein According to a report, mice die of respiratory failure shortly after birth (PubMed:10400672). According to a second report, mice exhibit perturbed terminal branching of motor neurons to the endplate of skeletal muscles, resulting in poor formation of the neuromuscular junction (PubMed:23261301). Belongs to the peptidase M13 family. respiratory system process metalloendopeptidase activity integral component of plasma membrane proteolysis neuropeptide signaling pathway peptidase activity metallopeptidase activity membrane integral component of membrane hydrolase activity intracellular signal transduction metal ion binding uc007bwc.1 uc007bwc.2 uc007bwc.3 uc007bwc.4 
ENSMUST00000161006.3 1700023H06Rik ENSMUST00000161006.3 1700023H06Rik (from geneSymbol) AK006278 ENSMUST00000161006.1 ENSMUST00000161006.2 uc288oum.1 uc288oum.2 uc288oum.3 uc288oum.1 uc288oum.2 uc288oum.3 
ENSMUST00000161012.8 Tcf19 ENSMUST00000161012.8 transcription factor 19, transcript variant 3 (from RefSeq NM_025674.2) ENSMUST00000161012.1 ENSMUST00000161012.2 ENSMUST00000161012.3 ENSMUST00000161012.4 ENSMUST00000161012.5 ENSMUST00000161012.6 ENSMUST00000161012.7 G3XA31 G3XA31_MOUSE NM_025674 Tcf19 uc008chv.1 uc008chv.2 uc008chv.3 uc008chv.4 uc008chv.1 uc008chv.2 uc008chv.3 uc008chv.4 
ENSMUST00000161017.8 Kif26b ENSMUST00000161017.8 kinesin family member 26B (from RefSeq NM_001161665.1) D5MP63 E9PXV6 ENSMUST00000161017.1 ENSMUST00000161017.2 ENSMUST00000161017.3 ENSMUST00000161017.4 ENSMUST00000161017.5 ENSMUST00000161017.6 ENSMUST00000161017.7 KI26B_MOUSE NM_001161665 Q0VB48 Q7TNC6 Q8BHX2 Q8BKH6 uc007dvh.1 uc007dvh.2 uc007dvh.3 uc007dvh.4 Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules. Interacts with MYH10. Q7TNC6; Q61879: Myh10; NbExp=3; IntAct=EBI-15852098, EBI-400918; Cytoplasm Cytoplasm, cytoskeleton In newborn kidney, specifically expressed in the mesenchyme. In the developing kidney, only present in the uncommitted mesenchyme and absent from more differentiated structures including renal vesicles and comma-shaped bodies. First detected in the metanephric mesenchyme at 10.5 dpc. After 11.5 dpc, observed in mesenchymal cells surrounding the tips of ureteric buds in the metanephroi. At 11.5 dpc, also detected in limb buds and central nervous system. At 14.5 dpc, strongly expressed in the nephrogenic zone. Up-regulated by SALL1. Phosphorylation at Thr-1859 and Ser-1962 by CDKs, mainly CDK2 and CDK5, enhances the interaction with NEDD4, polyubiquitination, and subsequent proteasomal degradation. Phosphorylation occurs upon loss of interaction with microtubules. Polyubiquitinated by NEDD4, resulting in proteasomal degradation. Mutant mice die within 24 hours after birth. Most mice show bilateral kidney agenesis. The development of other organs seems normal. Ureteric bud attraction is impaired after 11.0 dpc. The ureteric buds are attracted close to the mesenchyme but fail to invade and branch into the mesenchyme and the kidney disappears by 14.5 dpc. The mesenchymal cells undergo apoptotic cell death at 12.5 dpc. ITGA8 is reduced at the ureteric bud/mesenchyme junction and does not exhibit basolateral localization. GDNF is not properly maintained in the mesenchyme at 11.5 dpc. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily. Sequence=AAH56349.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC36343.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding microtubule motor activity protein binding ATP binding cytoplasm cytoskeleton kinesin complex microtubule multicellular organism development microtubule binding ATP-dependent microtubule motor activity, plus-end-directed positive regulation of cell-cell adhesion establishment of cell polarity ureteric bud invasion microtubule-based movement ATPase activity uc007dvh.1 uc007dvh.2 uc007dvh.3 uc007dvh.4 
ENSMUST00000161023.8 Slirp ENSMUST00000161023.8 SRA stem-loop interacting RNA binding protein (from RefSeq NM_026958.3) ENSMUST00000161023.1 ENSMUST00000161023.2 ENSMUST00000161023.3 ENSMUST00000161023.4 ENSMUST00000161023.5 ENSMUST00000161023.6 ENSMUST00000161023.7 NM_026958 Q497G4 Q99JH3 Q9D8T7 SLIRP_MOUSE uc007ojd.1 uc007ojd.2 uc007ojd.3 uc007ojd.4 RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation (By similarity). Mitochondrion Nucleus Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D8T7-1; Sequence=Displayed; Name=2; IsoId=Q9D8T7-2; Sequence=VSP_019907; Sequence=CAC34586.1; Type=Frameshift; Evidence=; negative regulation of mitochondrial RNA catabolic process acrosomal vesicle nucleic acid binding RNA binding nucleus cytoplasm mitochondrion spermatid development single fertilization flagellated sperm motility sperm flagellum perinuclear region of cytoplasm mitochondrion morphogenesis ribonucleoprotein complex uc007ojd.1 uc007ojd.2 uc007ojd.3 uc007ojd.4 
ENSMUST00000161028.2 Fer1l6 ENSMUST00000161028.2 fer-1 like family member 6 (from RefSeq NM_001370912.1) E0CZ42 E0CZ42_MOUSE ENSMUST00000161028.1 Fer1l6 NM_001370912 uc288yen.1 uc288yen.2 molecular_function cellular_component response to bacterium membrane integral component of membrane uc288yen.1 uc288yen.2 
ENSMUST00000161029.9 Spmip8 ENSMUST00000161029.9 sperm microtubule inner protein 8, transcript variant 1 (from RefSeq NM_199455.2) ENSMUST00000161029.1 ENSMUST00000161029.2 ENSMUST00000161029.3 ENSMUST00000161029.4 ENSMUST00000161029.5 ENSMUST00000161029.6 ENSMUST00000161029.7 ENSMUST00000161029.8 NM_199455 Q3SXB6 Q6IMH0 Q9D9K7 SMIP8_MOUSE Tepp uc009myd.1 uc009myd.2 uc009myd.3 uc009myd.4 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella. Cytoplasm, cytoskeleton, flagellum axoneme Note=Localizes to the A-tubules of DMTs. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6IMH0-1; Sequence=Displayed; Name=2; IsoId=Q6IMH0-2; Sequence=VSP_032404; Expressed in testis. Deficient mice are viable and have normal fertility. molecular_function cellular_component biological_process uc009myd.1 uc009myd.2 uc009myd.3 uc009myd.4 
ENSMUST00000161046.9 Usp7 ENSMUST00000161046.9 ubiquitin specific peptidase 7 (from RefSeq NM_001003918.2) ENSMUST00000161046.1 ENSMUST00000161046.2 ENSMUST00000161046.3 ENSMUST00000161046.4 ENSMUST00000161046.5 ENSMUST00000161046.6 ENSMUST00000161046.7 ENSMUST00000161046.8 F8VPX1 F8VPX1_MOUSE NM_001003918 Usp7 uc007ycw.1 uc007ycw.2 uc007ycw.3 Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Belongs to the peptidase C19 family. p53 binding cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus cytosol transcription-coupled nucleotide-excision repair ubiquitin-dependent protein catabolic process protein C-terminus binding transcription factor binding maintenance of DNA methylation protein deubiquitination ubiquitin protein ligase binding regulation of protein stability negative regulation of NF-kappaB transcription factor activity negative regulation of proteasomal ubiquitin-dependent protein catabolic process macromolecular complex monoubiquitinated protein deubiquitination thiol-dependent ubiquitinyl hydrolase activity regulation of circadian rhythm protein stabilization regulation of sequence-specific DNA binding transcription factor activity protein K48-linked deubiquitination ubiquitinyl hydrolase activity positive regulation of DNA demethylation Lys48-specific deubiquitinase activity uc007ycw.1 uc007ycw.2 uc007ycw.3 
ENSMUST00000161053.8 Cldn16 ENSMUST00000161053.8 claudin 16 (from RefSeq NM_053241.5) CLD16_MOUSE ENSMUST00000161053.1 ENSMUST00000161053.2 ENSMUST00000161053.3 ENSMUST00000161053.4 ENSMUST00000161053.5 ENSMUST00000161053.6 ENSMUST00000161053.7 NM_053241 Q542L7 Q925N4 uc007yva.1 uc007yva.2 uc007yva.3 uc007yva.4 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is critical for renal paracellular epithelial transport of Ca(2+) and Mg(2+) in the thick ascending loop of Henle. The gene deficiency leads to specific alterations in renal Ca(2+) and Mg(2+) balance and also to disturbances in Na(+) handling. The interaction of this gene and the Cldn 19 gene is required for their assembly into tight junctions and for renal Mg(2+) reabsorption. This gene and the Cldn1 gene are clustered on chromosome 16. [provided by RefSeq, Aug 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK085333.1, AK085268.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity). Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Belongs to the claudin family. structural molecule activity plasma membrane bicellular tight junction ion transport membrane integral component of membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding positive regulation of calcium ion transport transepithelial transport uc007yva.1 uc007yva.2 uc007yva.3 uc007yva.4 
ENSMUST00000161074.8 Hint3 ENSMUST00000161074.8 histidine triad nucleotide binding protein 3 (from RefSeq NM_025798.3) ENSMUST00000161074.1 ENSMUST00000161074.2 ENSMUST00000161074.3 ENSMUST00000161074.4 ENSMUST00000161074.5 ENSMUST00000161074.6 ENSMUST00000161074.7 HINT3_MOUSE Hint4 NM_025798 Q9CPS6 uc007etg.1 uc007etg.2 uc007etg.3 Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha- acetyl lysine methyl ester)) generated by lysine tRNA ligase (By similarity). Reaction=adenosine 5'-phosphoramidate + H2O = AMP + NH4(+); Xref=Rhea:RHEA:67916, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57890, ChEBI:CHEBI:456215; Evidence=; Forms dimers to octamers and even larger oligomer (By similarity). Interacts with CALM1 (PubMed:31088288). Cytoplasm Nucleus Belongs to the HINT family. nucleotide binding catalytic activity nucleus cytoplasm hydrolase activity identical protein binding protein homodimerization activity protein homotetramerization uc007etg.1 uc007etg.2 uc007etg.3 
ENSMUST00000161126.2 Gm15759 ENSMUST00000161126.2 Gm15759 (from geneSymbol) AK028685 ENSMUST00000161126.1 uc287iid.1 uc287iid.2 uc287iid.1 uc287iid.2 
ENSMUST00000161132.10 Cep295 ENSMUST00000161132.10 Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure. Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles. Also required for centriole-to- centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement. Binds to and stabilizes centriolar microtubule. (from UniProt Q8BQ48) AK030838 CE295_MOUSE Cep295 ENSMUST00000161132.1 ENSMUST00000161132.2 ENSMUST00000161132.3 ENSMUST00000161132.4 ENSMUST00000161132.5 ENSMUST00000161132.6 ENSMUST00000161132.7 ENSMUST00000161132.8 ENSMUST00000161132.9 Kiaa1731 Q0VF60 Q3UYP6 Q571B9 Q8BQ48 Q8CCJ2 Q8CDA9 uc292eqc.1 uc292eqc.2 uc292eqc.3 Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure. Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles. Also required for centriole-to- centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement. Binds to and stabilizes centriolar microtubule. Interacts (via ALMS motif) with microtubules; this interaction is direct. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton Note=Associates with both of the converted centrioles during G1 but becomes more enriched at the newly formed daughter (or unconverted) centrioles during S, G2, and early M phases. In early S phase, localized at the procentriolar microtubule wall and enriched at the proximal ends of the centrioles in CENPJ- and CEP135-dependent manner. Colocalizes with SASS6 and CEP250 proteins. Colocalizes with CEP135 and CEP192 at the centrosomes. Associates with interphase microtubules and mitotic spindles. Colocalizes with centriolar acetylated tubulin. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8BQ48-1; Sequence=Displayed; Name=2; IsoId=Q8BQ48-2; Sequence=VSP_032298; Name=3; IsoId=Q8BQ48-3; Sequence=VSP_032294; Name=4; IsoId=Q8BQ48-4; Sequence=VSP_032292, VSP_032293, VSP_032294; Name=5; IsoId=Q8BQ48-5; Sequence=VSP_032295, VSP_032296, VSP_032297; Name=6; IsoId=Q8BQ48-6; Sequence=VSP_032294, VSP_032296, VSP_032297; The N-terminal and the ALMS motif-containing C-terminal regions are essential for CEP295-mediated centriole elongation. Sequence=AAI18969.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC27153.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD90195.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cytoplasm centrosome centriole microtubule organizing center spindle cytosol cytoskeleton plasma membrane microtubule binding positive regulation of centrosome duplication regulation of centriole replication positive regulation of protein acetylation positive regulation of centriole elongation positive regulation of establishment of protein localization mitotic spindle microtubule uc292eqc.1 uc292eqc.2 uc292eqc.3 
ENSMUST00000161137.8 Pdcd10 ENSMUST00000161137.8 programmed cell death 10 (from RefSeq NM_019745.4) ENSMUST00000161137.1 ENSMUST00000161137.2 ENSMUST00000161137.3 ENSMUST00000161137.4 ENSMUST00000161137.5 ENSMUST00000161137.6 ENSMUST00000161137.7 NM_019745 PDC10_MOUSE Q8VE70 Q9DAR3 Q9WV43 Tfar15 uc008pnc.1 uc008pnc.2 uc008pnc.3 uc008pnc.4 Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex (By similarity). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Homodimer. Interacts (via C-terminus) with CCM2. Interacts (via C-terminus) with PXN. Interacts (via N-terminus) with STK25. Interacts (via N-terminus) with STK26. Interacts (via N-terminus) with STK24. Interacts with GOLGA2. Identified in a complex with KRIT1 and CCM2. Interacts with KDR/VEGFR2 (By similarity). Interaction with KDR/VEGFR2 is enhanced by stimulation with VEGFA (PubMed:20371769). Interacts with RIPOR1 (via C-terminus); this interaction is required for the association of RIPOR1 with either STK24 and STK26 kinases and occurs in a Rho-independent manner (By similarity). Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Partially colocalizes with endogenous PXN at the leading edges of migrating cells. Lethal at an early embryonic stage due to defects in angiogenesis, vasculogenesis and hematopoiesis. Mice exhibit low levels of KDR/VEGFR2. Belongs to the PDCD10 family. Golgi membrane angiogenesis protein binding cytoplasm Golgi apparatus cytosol plasma membrane apoptotic process positive regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression membrane protein kinase binding positive regulation of cell migration positive regulation of stress-activated MAPK cascade positive regulation of peptidyl-serine phosphorylation intrinsic apoptotic signaling pathway in response to hydrogen peroxide response to hydrogen peroxide protein homodimerization activity negative regulation of apoptotic process positive regulation of MAP kinase activity wound healing, spreading of cells positive regulation of Notch signaling pathway protein N-terminus binding protein stabilization establishment of Golgi localization positive regulation of protein serine/threonine kinase activity negative regulation of cell migration involved in sprouting angiogenesis Golgi reassembly positive regulation of intracellular protein transport negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis cellular response to leukemia inhibitory factor uc008pnc.1 uc008pnc.2 uc008pnc.3 uc008pnc.4 
ENSMUST00000161170.2 Zfp9 ENSMUST00000161170.2 zinc finger protein 9 (from RefSeq NM_011763.2) ENSMUST00000161170.1 NM_011763 Q8BIS1 Q8BIS1_MOUSE Zfp9 uc009dlq.1 uc009dlq.2 uc009dlq.3 molecular_function nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc009dlq.1 uc009dlq.2 uc009dlq.3 
ENSMUST00000161178.2 Pheta2 ENSMUST00000161178.2 PH domain containing endocytic trafficking adaptor 2, transcript variant 1 (from RefSeq NM_001357717.1) A0A0R4J1Z2 A0A0R4J1Z2_MOUSE ENSMUST00000161178.1 Fam109b NM_001357717 Pheta2 uc007wyy.1 uc007wyy.2 uc007wyy.3 Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B. Early endosome Recycling endosome Golgi apparatus, trans-Golgi network Cytoplasmic vesicle, clathrin-coated vesicle Belongs to the sesquipedalian family. receptor recycling early endosome trans-Golgi network cytosol endosome organization clathrin-coated vesicle retrograde transport, endosome to Golgi protein homodimerization activity recycling endosome uc007wyy.1 uc007wyy.2 uc007wyy.3 
ENSMUST00000161198.4 Nat8f1 ENSMUST00000161198.4 N-acetyltransferase 8 (GCN5-related) family member 1 (from RefSeq NM_023160.3) CMLO1_MOUSE Cml1 ENSMUST00000161198.1 ENSMUST00000161198.2 ENSMUST00000161198.3 NM_023160 Q91XE3 Q9CW77 Q9JIZ0 uc009cqk.1 uc009cqk.2 uc009cqk.3 uc009cqk.4 uc009cqk.5 May play a role in regulation of gastrulation. Membrane ; Single-pass membrane protein Belongs to the camello family. gastrulation with mouth forming second lysine N-acetyltransferase activity, acting on acetyl phosphate as donor mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus negative regulation of cell adhesion multicellular organism development gastrulation N-acetyltransferase activity positive regulation of gene expression membrane integral component of membrane transferase activity transferase activity, transferring acyl groups peptidyl-lysine N6-acetylation endoplasmic reticulum-Golgi intermediate compartment membrane negative regulation of apoptotic process beta-amyloid metabolic process extracellular space uc009cqk.1 uc009cqk.2 uc009cqk.3 uc009cqk.4 uc009cqk.5 
ENSMUST00000161203.8 Rnf214 ENSMUST00000161203.8 ring finger protein 214, transcript variant 3 (from RefSeq NM_001310840.2) ENSMUST00000161203.1 ENSMUST00000161203.2 ENSMUST00000161203.3 ENSMUST00000161203.4 ENSMUST00000161203.5 ENSMUST00000161203.6 ENSMUST00000161203.7 NM_001310840 Q3UWM9 Q6P3A7 Q80VI8 Q8BFU3 Q8BNZ6 Q8CC56 Q8CCP2 Q8CE92 Q8R5B9 RN214_MOUSE uc009pgm.1 uc009pgm.2 uc009pgm.3 uc009pgm.4 Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8BFU3-1; Sequence=Displayed; Name=2; IsoId=Q8BFU3-2; Sequence=VSP_023774, VSP_023775; Name=3; IsoId=Q8BFU3-3; Sequence=VSP_023773; Name=4; IsoId=Q8BFU3-4; Sequence=VSP_023776; Name=5; IsoId=Q8BFU3-5; Sequence=VSP_023774; [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=AAH49909.1; Type=Erroneous initiation; Evidence=; Sequence=BAC28499.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAC37365.1; Type=Erroneous initiation; Evidence=; Sequence=BAE22885.1; Type=Erroneous initiation; Evidence=; ubiquitin-protein transferase activity cellular_component protein ubiquitination metal ion binding uc009pgm.1 uc009pgm.2 uc009pgm.3 uc009pgm.4 
ENSMUST00000161204.8 Rdh11 ENSMUST00000161204.8 retinol dehydrogenase 11, transcript variant 1 (from RefSeq NM_021557.6) Arsdr1 ENSMUST00000161204.1 ENSMUST00000161204.2 ENSMUST00000161204.3 ENSMUST00000161204.4 ENSMUST00000161204.5 ENSMUST00000161204.6 ENSMUST00000161204.7 Mdt1 NM_021557 Psdr1 Q3UXM9 Q9D0U5 Q9QYF1 RDH11_MOUSE uc007oaa.1 uc007oaa.2 uc007oaa.3 Retinol dehydrogenase with a clear preference for NADP (PubMed:12807874, PubMed:29567832). Displays high activity towards 9- cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis- retinol (By similarity) (PubMed:12807874). Exhibits also reductive activity towards toxic lipid peroxidation products such as medium-chain aldehydes trans-2-nonenal, nonanal, and cis-6-nonenal (PubMed:12807874). Has no dehydrogenase activity towards steroid (PubMed:12807874). Seems to be required for homeostasis of retinol in liver and testis (PubMed:29567832). Reaction=all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH; Xref=Rhea:RHEA:25033, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.300; Evidence= Reaction=11-cis-retinol + NADP(+) = 11-cis-retinal + H(+) + NADPH; Xref=Rhea:RHEA:54912, ChEBI:CHEBI:15378, ChEBI:CHEBI:16066, ChEBI:CHEBI:16302, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Reaction=9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH; Xref=Rhea:RHEA:54916, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78272, ChEBI:CHEBI:78273; Evidence=; Reaction=13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH; Xref=Rhea:RHEA:54920, ChEBI:CHEBI:15378, ChEBI:CHEBI:45479, ChEBI:CHEBI:45487, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Reaction=a medium-chain primary fatty alcohol + NADP(+) = a medium- chain fatty aldehyde + H(+) + NADPH; Xref=Rhea:RHEA:58364, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142605, ChEBI:CHEBI:142621; Evidence=; Reaction=(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) = (2E,6Z)-nona-2,6-dienal + H(+) + NADPH; Xref=Rhea:RHEA:58368, ChEBI:CHEBI:7610, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142615; Evidence=; Reaction=(E)-oct-2-en-1-ol + NADP(+) = (2E)-octenal + H(+) + NADPH; Xref=Rhea:RHEA:58372, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61748, ChEBI:CHEBI:142616; Evidence=; Reaction=(E)-non-2-en-1-ol + NADP(+) = (E)-non-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:58332, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142592, ChEBI:CHEBI:142604; Evidence=; Reaction=heptan-1-ol + NADP(+) = H(+) + heptanal + NADPH; Xref=Rhea:RHEA:58400, ChEBI:CHEBI:15378, ChEBI:CHEBI:34787, ChEBI:CHEBI:43003, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Reaction=hexan-1-ol + NADP(+) = H(+) + hexanal + NADPH; Xref=Rhea:RHEA:58404, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:87393, ChEBI:CHEBI:88528; Evidence=; Reaction=decan-1-ol + NADP(+) = decanal + H(+) + NADPH; Xref=Rhea:RHEA:58376, ChEBI:CHEBI:15378, ChEBI:CHEBI:28903, ChEBI:CHEBI:31457, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Reaction=NADP(+) + nonan-1-ol = H(+) + NADPH + nonanal; Xref=Rhea:RHEA:58380, ChEBI:CHEBI:15378, ChEBI:CHEBI:35986, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:84268; Evidence=; Reaction=NADP(+) + octan-1-ol = H(+) + NADPH + octanal; Xref=Rhea:RHEA:58384, ChEBI:CHEBI:15378, ChEBI:CHEBI:16188, ChEBI:CHEBI:17935, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; Reaction=(Z)-non-6-en-1-ol + NADP(+) = (Z)-non-6-enal + H(+) + NADPH; Xref=Rhea:RHEA:58328, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142591, ChEBI:CHEBI:142603; Evidence=; Kinetic parameters: KM=57 uM for all-trans-retinal ; KM=14 uM for 9-cis-retinal ; KM=30 uM for nonan-1-ol ; KM=20 uM for NADPH ; Note=kcat is 167 min(-1) for NADPH as substrate. ; pH dependence: Optimum pH is between 6.5 and 7.5 for nonanal as substrate. ; Cofactor metabolism; retinol metabolism. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced.; Name=1; IsoId=Q9QYF1-1; Sequence=Displayed; Expressed at high level in liver and testis (PubMed:12807874, PubMed:15790565, PubMed:29567832). Expressed at lower levels in smooth muscle, thymus, submaxillary gland and epididymis. In testis, expression is restricted to pachytene spermatocytes. Also expressed in four layers of the retina, including the outer segment of rods and cones (PubMed:12807874, PubMed:15790565). Down-regulated in liver by fasting and rose by refeeding. Not glycosylated. Deficient mice are fertile and developed normally but exhibit delayed dark adaptation vision (PubMed:15790565). Testis and livers of deficient mice exhibit a lower rate of all-trans-retinal conversion to all-trans-retinol (PubMed:29567832). Shows clear specificity for the pro-S hydrogen on C4 of NADPH and the pro-R hydrogen on C15 of retinols. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Sequence=BAA88521.1; Type=Frameshift; Evidence=; retinoid metabolic process photoreceptor inner segment retinol dehydrogenase activity endoplasmic reticulum endoplasmic reticulum membrane visual perception membrane integral component of membrane adaptation of rhodopsin mediated signaling oxidoreductase activity aldehyde dehydrogenase (NADP+) activity retinol metabolic process retinal metabolic process NADP-retinol dehydrogenase activity oxidation-reduction process photoreceptor outer segment membrane uc007oaa.1 uc007oaa.2 uc007oaa.3 
ENSMUST00000161211.8 Med6 ENSMUST00000161211.8 mediator complex subunit 6, transcript variant 1 (from RefSeq NM_001347384.1) ENSMUST00000161211.1 ENSMUST00000161211.2 ENSMUST00000161211.3 ENSMUST00000161211.4 ENSMUST00000161211.5 ENSMUST00000161211.6 ENSMUST00000161211.7 MED6_MOUSE NM_001347384 Q3TAK5 Q8BTP9 Q921D4 uc007ocl.1 uc007ocl.2 uc007ocl.3 uc007ocl.4 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CTNNB1 and GLI3 (By similarity). Nucleus Belongs to the Mediator complex subunit 6 family. Sequence=AAH13096.1; Type=Erroneous initiation; Evidence=; Sequence=BAE42663.1; Type=Frameshift; Evidence=; ubiquitin ligase complex DNA binding transcription cofactor activity transcription coactivator activity protein binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter transcription factor binding protein ubiquitination mediator complex stem cell population maintenance positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcriptional preinitiation complex assembly ubiquitin protein ligase activity core mediator complex uc007ocl.1 uc007ocl.2 uc007ocl.3 uc007ocl.4 
ENSMUST00000161216.4 2310075C17Rik ENSMUST00000161216.4 RIKEN cDNA 2310075C17 gene (from RefSeq NR_131053.1) ENSMUST00000161216.1 ENSMUST00000161216.2 ENSMUST00000161216.3 NR_131053 uc057aqi.1 uc057aqi.2 uc057aqi.3 uc057aqi.4 uc057aqi.5 uc057aqi.1 uc057aqi.2 uc057aqi.3 uc057aqi.4 uc057aqi.5 
ENSMUST00000161226.11 Auts2 ENSMUST00000161226.11 autism susceptibility candidate 2 (from RefSeq NM_001363480.1) A0A087WPF7 AUTS2_MOUSE E9PWJ4 ENSMUST00000161226.1 ENSMUST00000161226.10 ENSMUST00000161226.2 ENSMUST00000161226.3 ENSMUST00000161226.4 ENSMUST00000161226.5 ENSMUST00000161226.6 ENSMUST00000161226.7 ENSMUST00000161226.8 ENSMUST00000161226.9 Kiaa0442 NM_001363480 Q6ZQB3 Q8BWI6 uc291agr.1 uc291agr.2 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B. As a consequence, the complex mediates transcriptional activation (By similarity). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (PubMed:25533347). Component of a PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 (PubMed:25519132). Within this complex, interacts directly with PCGF5 and CSNK2B (By similarity). Interacts with the histone acetyltransferase EP300/p300 (By similarity). Interacts (via Pro-rich region) with PREX1, DOCK1 and ELMO2 (PubMed:25533347). A0A087WPF7; B2RWS6: Ep300; NbExp=3; IntAct=EBI-27122375, EBI-3953360; A0A087WPF7; Q61985: Nfe2l1; NbExp=3; IntAct=EBI-27122375, EBI-30865042; A0A087WPF7; Q99K48: Nono; NbExp=4; IntAct=EBI-27122375, EBI-607499; A0A087WPF7; Q9CQJ4: Rnf2; NbExp=2; IntAct=EBI-27122375, EBI-927321; Nucleus toplasm, cytoskeleton Cell projection, growth cone Note=Detected both in cytoplasm and nucleus (PubMed:25533347). Colocalizes with RAC1 at actin-rich growth cones (PubMed:25533347). Detected on the promoter region of actively transcribed genes (PubMed:25519132). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A0A087WPF7-1; Sequence=Displayed; Name=2; IsoId=A0A087WPF7-2; Sequence=VSP_059125, VSP_059126; Name=3; IsoId=A0A087WPF7-3; Sequence=VSP_059124, VSP_059127; Detected in brain cortex in embryo, neonates and adults (at protein level) (PubMed:19948250, PubMed:25533347, PubMed:25519132). Detected in embryonic and adult Purkinje cells in the cerebellum (PubMed:19948250). Detected in dorsal thalamus and in dopaminergic neurons in substantia nigra (PubMed:19948250). Detected in embryonic brain cortex at 15 dpc, and at clearly lower levels in adult brain cortex, hippocampus and in cerebellum Purkinje cells (at protein level) (PubMed:25519132). Very low and barely detectable in embryonic brain at 11 dpc. Detected in the developing brain cortex, thalamus and cerebellum at 12 and 14 dpc. Uniformly expressed all along the preplate at 13 dpc. At 16 dpc, highly expressed in neurons in deep and superficial layers of the frontal cortical region of the preplate, with much lower expression in the caudal region or the preplate. Highly expressed in thalamus at 14 dpc, and at much lower levels in adults. Highly expressed in hippocampus after 13 dpc; expression levels increase subsequently and are high in dentate gyrus and the CA region of the hippocampus at 19 dpc. Expression in dentate gyrus, granule cell layer and the CA region of the hippocampus continues in neonates and into adulthood. The Pro-rich region is important for the interaction with RAC guanine nucleotide exchange factors and the subsequent activation of RAC1, which then promotes lamellipodia formation. Brain-specific gene disruption gives rise to no visible phenotype at birth. Mutant mice have normal weight at birth, but then show decreased weight gain over the next few days, decreased milk uptake, impaired motor skills and impaired ultrasonic vocalization after maternal separation. Belongs to the AUTS2 family. neuron migration chromatin binding protein binding nucleus cytoplasm cytoskeleton positive regulation of lamellipodium assembly growth cone actin cytoskeleton reorganization positive regulation of Rac protein signal transduction cell projection positive regulation of transcription from RNA polymerase II promoter axon extension positive regulation of histone H3-K4 methylation righting reflex dendrite extension innate vocalization behavior positive regulation of histone H4-K16 acetylation actin cytoskeleton uc291agr.1 uc291agr.2 
ENSMUST00000161240.4 Galnt4 ENSMUST00000161240.4 polypeptide N-acetylgalactosaminyltransferase 4 (from RefSeq NM_015737.4) ENSMUST00000161240.1 ENSMUST00000161240.2 ENSMUST00000161240.3 GALT4_MOUSE NM_015737 O08832 Q3U681 uc007gxj.1 uc007gxj.2 uc007gxj.3 uc007gxj.4 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward EA2 peptide substrate and a much lower activity with EPO-T, Muc2, Muc1a, Muc1b. Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Evidence=; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Highly expressed in sublingual gland, stomach, colon, small intestine and cervix. Expressed at intermediate levels in kidney, ovary, lung and uterus. Weakly expressed in spleen, liver, heart and brain. Not expressed in submandibular and parotid glands, skeletal muscle and testis. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Name=Functional Glycomics Gateway - GTase; Note=Polypeptide N-acetylgalactosaminyltransferase 4; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_513"; Golgi membrane polypeptide N-acetylgalactosaminyltransferase activity Golgi apparatus protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via serine protein O-linked glycosylation via threonine manganese ion binding carbohydrate binding metal ion binding perinuclear region of cytoplasm uc007gxj.1 uc007gxj.2 uc007gxj.3 uc007gxj.4 
ENSMUST00000161241.8 Usf1 ENSMUST00000161241.8 upstream transcription factor 1, transcript variant 9 (from RefSeq NM_001421593.1) ENSMUST00000161241.1 ENSMUST00000161241.2 ENSMUST00000161241.3 ENSMUST00000161241.4 ENSMUST00000161241.5 ENSMUST00000161241.6 ENSMUST00000161241.7 NM_001421593 Q61069 USF1_MOUSE Usf uc007doj.1 uc007doj.2 uc007doj.3 uc007doj.4 Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2). Q61069; P42225: Stat1; NbExp=2; IntAct=EBI-2325635, EBI-647118; Nucleus. positive regulation of transcription from RNA polymerase II promoter by glucose nuclear chromatin RNA polymerase II transcription factor activity, sequence-specific DNA binding response to hypoxia DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex glucose metabolic process regulation of transcription, DNA-templated transcription from RNA polymerase II promoter response to UV late viral transcription enzyme binding protein kinase binding cellular response to insulin stimulus identical protein binding protein homodimerization activity histone deacetylase binding bHLH transcription factor binding sequence-specific DNA binding macromolecular complex binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein dimerization activity lipid homeostasis uc007doj.1 uc007doj.2 uc007doj.3 uc007doj.4 
ENSMUST00000161244.2 Gm15679 ENSMUST00000161244.2 predicted gene 15679 (from RefSeq NR_110579.1) ENSMUST00000161244.1 NR_110579 uc292cnn.1 uc292cnn.2 uc292cnn.1 uc292cnn.2 
ENSMUST00000161263.8 Sv2c ENSMUST00000161263.8 synaptic vesicle glycoprotein 2c (from RefSeq NM_029210.1) ENSMUST00000161263.1 ENSMUST00000161263.2 ENSMUST00000161263.3 ENSMUST00000161263.4 ENSMUST00000161263.5 ENSMUST00000161263.6 ENSMUST00000161263.7 Kiaa1054 NM_029210 Q69ZS6 SV2C_MOUSE uc007rmt.1 uc007rmt.2 uc007rmt.3 uc007rmt.4 Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin binds Sv2c via extracellular loop 4 (PubMed:16543415). (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD) (PubMed:21483489). Interacts with SYT1 in a calcium-dependent manner. (Microbial infection) Interacts with C.botulinum neurotoxin type A (BoNT/A, botA). (Microbial infection) Interacts with C.botulinum neurotoxin type D (BoNT/D, botD). Q69ZS6; O55042: Snca; NbExp=2; IntAct=EBI-36944762, EBI-2310271; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Note=Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas. Expressed in specific subsets of conventional synapses in the retina (at protein level) (PubMed:12687700). Expressed in diaphragm motor nerve terminals (at protein level) (PubMed:16543415). Expressed in a subset of hippocampus neurons (at protein level) (PubMed:18815274, PubMed:21483489). Expressed during synaptogenesis in the retina (at protein level). Up-regulated upon Sv2a depletion. N-glycosylated. Small interfering RNA knockdown of the protein in Neuro-2a cells (which only express this SV2 protein) prevents uptake of C.botulinum neurotoxin type A (BoNT/A, botA); uptake is restored by expression of rat SV2A or SV2B (PubMed:16543415). Belongs to the major facilitator superfamily. The use of this protein as a coreceptor for C.botulinum type D (BoNT/D, botD) is controversial. In double SV2A/SV2B knockout mice BoNT/D does not degrade its synaptobrevin target; introducing SV2A, SV2B or SV2C restores target cleavage (PubMed:21483489). However another group does not find a convincing interaction with SV2 (PubMed:21632541). Sequence=BAD32370.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; integral component of plasma membrane neurotransmitter transport chemical synaptic transmission synaptic vesicle membrane integral component of membrane transmembrane transporter activity cell junction integral component of synaptic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle neuron projection synapse transmembrane transport uc007rmt.1 uc007rmt.2 uc007rmt.3 uc007rmt.4 
ENSMUST00000161273.8 Pitpnm2 ENSMUST00000161273.8 phosphatidylinositol transfer protein, membrane-associated 2, transcript variant 4 (from RefSeq NM_001424502.1) E9PYJ7 E9PYJ7_MOUSE ENSMUST00000161273.1 ENSMUST00000161273.2 ENSMUST00000161273.3 ENSMUST00000161273.4 ENSMUST00000161273.5 ENSMUST00000161273.6 ENSMUST00000161273.7 NM_001424502 Pitpnm2 uc290ztr.1 uc290ztr.2 Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. phospholipid transporter activity phospholipid transport metal ion binding uc290ztr.1 uc290ztr.2 
ENSMUST00000161279.8 Gal3st4 ENSMUST00000161279.8 galactose-3-O-sulfotransferase 4, transcript variant 3 (from RefSeq NM_001361283.1) ENSMUST00000161279.1 ENSMUST00000161279.2 ENSMUST00000161279.3 ENSMUST00000161279.4 ENSMUST00000161279.5 ENSMUST00000161279.6 ENSMUST00000161279.7 Gal3st4 NM_001361283 Q3V1B8 Q3V1B8_MOUSE uc291bby.1 uc291bby.2 Belongs to the galactose-3-O-sulfotransferase family. galactosylceramide sulfotransferase activity Golgi apparatus glycoprotein biosynthetic process glycolipid biosynthetic process membrane integral component of membrane galactose 3-O-sulfotransferase activity uc291bby.1 uc291bby.2 
ENSMUST00000161286.8 Tra2b ENSMUST00000161286.8 transformer 2 beta, transcript variant 1 (from RefSeq NM_009186.5) ENSMUST00000161286.1 ENSMUST00000161286.2 ENSMUST00000161286.3 ENSMUST00000161286.4 ENSMUST00000161286.5 ENSMUST00000161286.6 ENSMUST00000161286.7 NM_009186 O15449 P62996 Q15815 Q64283 Sfrs10 Silg41 TRA2B_MOUSE Tra2b uc007ysc.1 uc007ysc.2 uc007ysc.3 Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing (PubMed:28785060). Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity). Found in a pre-mRNA exonic splicing enhancer (ESE) complex with TRA2B/SFRS10, SNRNP70, SNRPA1 and SRRM1. Binds to A3 enhancer proteins SFRS4, SFRS5, SFRS6 and SFRS9. Interacts with CPSF6, RBMY1A1, RBMX, RNPS1 and phosphorylated SFRS13A (By similarity). Interacts with SAFB/SAFB1 (By similarity). Interacts with ILDR1 (via C-terminus) and ILDR2 (PubMed:28785060). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P62996-1; Sequence=Displayed; Name=2; IsoId=P62996-2; Sequence=VSP_011509, VSP_011510; Widely expressed. Highly expressed in uterus and brain. Expressed in inner ear (PubMed:28785060). Induced by reoxygenation following hypoxia and by exposure to silica. Repressed by interferon gamma, LPS and TPA. Phosphorylated in the RS domains. Belongs to the splicing factor SR family. regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding protein binding nucleus nucleoplasm spliceosomal complex mRNA processing RNA splicing protein domain specific binding cerebral cortex regionalization pre-mRNA binding identical protein binding regulation of RNA splicing positive regulation of mRNA splicing, via spliceosome perinuclear region of cytoplasm protein oligomerization poly-purine tract binding cellular response to glucose stimulus embryonic brain development ribonucleoprotein complex nuclear inner membrane uc007ysc.1 uc007ysc.2 uc007ysc.3 
ENSMUST00000161289.2 Ces4a ENSMUST00000161289.2 carboxylesterase 4A (from RefSeq NM_146213.2) Ces8 ENSMUST00000161289.1 EST4A_MOUSE G3XA24 NM_146213 Q8R0W5 uc009nbo.1 uc009nbo.2 Probable carboxylesterase. Secreted Belongs to the type-B carboxylesterase/lipase family. Sequence=AAH26374.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; sterol esterase activity triglyceride lipase activity extracellular region extracellular space lipid catabolic process hydrolase activity carboxylic ester hydrolase activity uc009nbo.1 uc009nbo.2 
ENSMUST00000161291.3 9230105E05Rik ENSMUST00000161291.3 RIKEN cDNA 9230105E05 gene (from RefSeq NR_040626.1) ENSMUST00000161291.1 ENSMUST00000161291.2 NR_040626 uc029rji.1 uc029rji.2 uc029rji.3 uc029rji.1 uc029rji.2 uc029rji.3 
ENSMUST00000161306.2 Tmprss11e ENSMUST00000161306.2 transmembrane protease, serine 11e (from RefSeq NM_172880.2) A4FUP5 Desc1 ENSMUST00000161306.1 NM_172880 Q5S248 Q8BM10 TM11E_MOUSE uc008xxv.1 uc008xxv.2 uc008xxv.3 Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. Inhibited by SERPINA5. Forms a heterodimer with SERPINA5 and SERPINE1. Q5S248; P70458: Serpina5; NbExp=2; IntAct=EBI-490889, EBI-490966; Q5S248; P22777: Serpine1; NbExp=2; IntAct=EBI-490889, EBI-490898; Cell membrane ; Single-pass type II membrane protein [Transmembrane protease serine 11E catalytic chain]: Secreted Note=Activated by cleavage and secreted. Expressed in epidermal, oral and male reproductive tissues. N-glycosylated. Belongs to the peptidase S1 family. Sequence=AAV52922.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; serine-type endopeptidase activity protein binding extracellular region plasma membrane integral component of plasma membrane proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity proteolysis in other organism viral entry into host cell cognition uc008xxv.1 uc008xxv.2 uc008xxv.3 
ENSMUST00000161308.8 H3f3a ENSMUST00000161308.8 H3.3 histone A (from RefSeq NM_008210.6) ENSMUST00000161308.1 ENSMUST00000161308.2 ENSMUST00000161308.3 ENSMUST00000161308.4 ENSMUST00000161308.5 ENSMUST00000161308.6 ENSMUST00000161308.7 H3-3a H3-3b H3.3a H3.3b H33_MOUSE H3f3a H3f3b NM_008210 P06351 P33155 P84244 Q3TW79 Q3U6D6 Q569U8 Q5HZY8 Q6TXQ5 Q8VDJ2 Q9D0H3 Q9V3W4 uc007dwr.1 uc007dwr.2 uc007dwr.3 uc007dwr.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Nov 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA465622.1, AK037900.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 9373943 ##RefSeq-Attributes-END## Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes. Interacts with ZMYND11; when trimethylated at 'Lys- 36' (H3.3K36me3). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). Interacts with ASF1A, MCM2, NASP and SPT2 (By similarity). Nucleus. Chromosome. Expressed throughout the cell cycle independently of DNA synthesis. Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with ZMYND11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains (By similarity). Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3). Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters. Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double- strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes. metaphase chromosomes. Ubiquitinated. Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H3 family. Sequence=AAH92300.1; Type=Frameshift; Evidence=; Sequence=BAB27616.1; Type=Frameshift; Evidence=; Sequence=BAE35387.1; Type=Frameshift; Evidence=; nuclear chromosome nuclear chromosome, telomeric region nucleosome nuclear nucleosome RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding osteoblast differentiation Barr body DNA binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-independent nucleosome assembly nucleus organization spermatogenesis spermatid development single fertilization brain development embryo implantation cell proliferation male gonad development response to hormone positive regulation of cell growth nucleosomal DNA binding pericentric heterochromatin assembly telomeric heterochromatin assembly macromolecular complex multicellular organism growth muscle cell differentiation protein heterodimerization activity oogenesis regulation of centromere complex assembly negative regulation of chromosome condensation uc007dwr.1 uc007dwr.2 uc007dwr.3 uc007dwr.4 
ENSMUST00000161319.2 Gm3513 ENSMUST00000161319.2 Gm3513 (from geneSymbol) ENSMUST00000161319.1 uc290gbh.1 uc290gbh.2 uc290gbh.1 uc290gbh.2 
ENSMUST00000161344.2 Gm15882 ENSMUST00000161344.2 Gm15882 (from geneSymbol) ENSMUST00000161344.1 uc292aby.1 uc292aby.2 uc292aby.1 uc292aby.2 
ENSMUST00000161347.9 Gcsam ENSMUST00000161347.9 germinal center associated, signaling and motility, transcript variant 1 (from RefSeq NM_001159297.1) ENSMUST00000161347.1 ENSMUST00000161347.2 ENSMUST00000161347.3 ENSMUST00000161347.4 ENSMUST00000161347.5 ENSMUST00000161347.6 ENSMUST00000161347.7 ENSMUST00000161347.8 GCSAM_MOUSE Gcet Gcet2 M17 NM_001159297 Q60691 Q6RFH4 Q8CB90 uc007zis.1 uc007zis.2 uc007zis.3 uc007zis.4 Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. Interacts with ACTB and MYH2; the interaction with MYH2 is increased by IL6-induced phosphorylation. Interacts (via C-terminus) with ARHGEF11 (via DH domain). Interacts with ARHGEF12. Interacts with SYK; the interaction increases after B-cell receptor stimulation, resulting in enhanced SYK autophosphorylation and activity. Cytoplasm Cell membrane Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=M17-L; IsoId=Q6RFH4-1; Sequence=Displayed; Name=2; IsoId=Q6RFH4-2; Sequence=VSP_021334; Highly expressed in normal germinal center (GC) B- cells. Expressed in spleen and, to a lesser extent, bone marrow. Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN. Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation. GCSAM transgenic mice develop B-cell lymphoid hyperplasia, hypergammaglobulinemia and systemic reactive amyloid A (AA) amyloidosis strating from 12 months of age. actin binding cytoplasm plasma membrane membrane protein kinase binding myosin II binding regulation of B cell receptor signaling pathway regulation of lymphocyte migration negative regulation of lymphocyte migration uc007zis.1 uc007zis.2 uc007zis.3 uc007zis.4 
ENSMUST00000161354.9 Abcg4 ENSMUST00000161354.9 ATP binding cassette subfamily G member 4 (from RefSeq NM_138955.3) ABCG4_MOUSE Abcg4 ENSMUST00000161354.1 ENSMUST00000161354.2 ENSMUST00000161354.3 ENSMUST00000161354.4 ENSMUST00000161354.5 ENSMUST00000161354.6 ENSMUST00000161354.7 ENSMUST00000161354.8 NM_138955 Q8K4E1 Q8VBS9 Q91WA9 White2 uc009pcq.1 uc009pcq.2 uc009pcq.3 ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (PubMed:15210959, PubMed:18039927, PubMed:17916878). May play an important role in the removal of amyloid- beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (PubMed:29042617). Induces apoptosis in various cells (By similarity). Reaction=ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate; Xref=Rhea:RHEA:39051, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39052; Evidence=; Reaction=ATP + desmosterol(in) + H2O = ADP + desmosterol(out) + H(+) + phosphate; Xref=Rhea:RHEA:67932, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17737, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67933; Evidence=; Half-transporter that forms a functional transporter via homo- or heterodimerization. Homodimer. Heterodimers with ABCG1. Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Endosome membrane ; Multi- pass membrane protein Highly expressed in the brain, in particular in neurons, microglia and astrocytes (PubMed:11856881, PubMed:12183068, PubMed:18039927, PubMed:17916878). Expressed on blood brain barrier endothelial cells (PubMed:29042617). Expressed in the spleen (PubMed:11856881). Highly but transiently expressed in enterocytes and hemopoietic cells populating the liver during development, but is absent when animals are fully developed. Highly expressed in the eyes of the developing embryos as early as 12.5 dpc and developing CNS. Abcg4 deficiency does not significantly affect the levels of sterols in the brain except for brain lathosterol levels, which are slightly elevated (PubMed:18039927). Abcg1/Abcg4 double knockout mice display significant accumulation of 24(S)- hydroxycholesterol (24S-HC) and 27-hydroxy-cholesterol (27-HC) in addition to the cholesterol synthesis intermediates, desmosterol, lanosterol and lathosterol (PubMed:19633360, PubMed:18039927). Whether ABCG4 is an LXR target gene, is still under debate. Studies performed in monocytes, and in one astrocyte cell line indicated that ABCG4 expression could be up-regulated by oxysterols and other LXR ligands (By similarity). However, subsequent observations in a number of different cell types (primary mouse cells, oligodendrocytes and neuron-like cell lines) have not confirmed this observation (PubMed:17916878) (By similarity). Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. nucleotide binding ATP binding plasma membrane membrane integral component of membrane ATPase activity cholesterol efflux ATPase activity, coupled to transmembrane movement of substances protein homodimerization activity protein heterodimerization activity transmembrane transport cellular response to leukemia inhibitory factor uc009pcq.1 uc009pcq.2 uc009pcq.3 
ENSMUST00000161362.8 Gm1965 ENSMUST00000161362.8 predicted gene 1965, transcript variant 2 (from RefSeq NR_121594.1) ENSMUST00000161362.1 ENSMUST00000161362.2 ENSMUST00000161362.3 ENSMUST00000161362.4 ENSMUST00000161362.5 ENSMUST00000161362.6 ENSMUST00000161362.7 NR_121594 uc009cwd.1 uc009cwd.2 uc009cwd.3 uc009cwd.4 uc009cwd.1 uc009cwd.2 uc009cwd.3 uc009cwd.4 
ENSMUST00000161366.2 Gm16055 ENSMUST00000161366.2 Gm16055 (from geneSymbol) ENSMUST00000161366.1 uc291cmi.1 uc291cmi.2 uc291cmi.1 uc291cmi.2 
ENSMUST00000161372.2 Panx2 ENSMUST00000161372.2 Structural component of the gap junctions and the hemichannels. (from UniProt Q6IMP4) B1PL20 ENSMUST00000161372.1 EU446266 PANX2_MOUSE Q4JGM2 Q6IMP4 uc289ang.1 uc289ang.2 Structural component of the gap junctions and the hemichannels. Forms PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes. Does not form homomeric channels (By similarity). Cell membrane ; Multi-pass membrane protein Cell junction, gap junction. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6IMP4-1; Sequence=Displayed; Name=2; IsoId=Q6IMP4-2; Sequence=VSP_039093, VSP_039094; Belongs to the pannexin family. Sequence=DAA00307.1; Type=Frameshift; Evidence=; response to ischemia gap junction channel activity cytoplasm plasma membrane gap junction ion transport cation transport cell-cell signaling channel activity membrane integral component of membrane wide pore channel activity cell junction protein hexamerization protein heterodimerization activity positive regulation of interleukin-1 secretion gap junction hemi-channel activity transmembrane transport uc289ang.1 uc289ang.2 
ENSMUST00000161389.8 Skint1 ENSMUST00000161389.8 May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. Plays a central role in mediating key epithelial-immune interactions by being involved in the selection of Vgamma5(+)Vdelta1(+) T-cells, which constitute 90% of epidermal gammadelta T-cells. (from UniProt A7TZE6) A7TZE6 A7TZE7 A7XUW2 A7XUW8 A7XUX1 A9XK90 ENSMUST00000161389.1 ENSMUST00000161389.2 ENSMUST00000161389.3 ENSMUST00000161389.4 ENSMUST00000161389.5 ENSMUST00000161389.6 ENSMUST00000161389.7 EU099296 SKIT1_MOUSE uc012dip.1 uc012dip.2 May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. Plays a central role in mediating key epithelial-immune interactions by being involved in the selection of Vgamma5(+)Vdelta1(+) T-cells, which constitute 90% of epidermal gammadelta T-cells. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=A; IsoId=A7TZE6-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=A7TZE6-2; Sequence=VSP_034875, VSP_034876; Name=3; Synonyms=C; IsoId=A7TZE6-3; Sequence=VSP_034873, VSP_034874; Name=4; Synonyms=D; IsoId=A7TZE6-4; Sequence=VSP_034871, VSP_034872; Expressed in skin and thymus. The strain FVB/NTac displays a selective deficiency for epidermal Vgamma5(+)Vdelta1(+) T-cells due to a mutation that creates premature codon stop at position 324. Encoded by one of the 11 copies of Skint genes clustered in the D1 region of the chromosome 4. Humans and chimpanzees have a SKINT1-like (SKINT1L) gene with multiple inactivating mutations. All hominoid species have a common inactivating mutation, but that Old World monkeys such as olive baboons, green monkeys, cynomolgus macaques and rhesus macaques have apparently functional SKINT1L sequences, indicating that SKINT1L is inactivated in a common ancestor of hominoids. Belongs to the SKINT family. receptor binding external side of plasma membrane membrane integral component of membrane positive regulation of T cell differentiation in thymus positive thymic T cell selection positive regulation of T cell differentiation regulation of immune response T cell receptor signaling pathway cell periphery uc012dip.1 uc012dip.2 
ENSMUST00000161394.2 Gm15688 ENSMUST00000161394.2 Gm15688 (from geneSymbol) AK035802 ENSMUST00000161394.1 uc290kdy.1 uc290kdy.2 uc290kdy.1 uc290kdy.2 
ENSMUST00000161395.2 Gm15947 ENSMUST00000161395.2 Gm15947 (from geneSymbol) AK146142 ENSMUST00000161395.1 uc289hvm.1 uc289hvm.2 uc289hvm.1 uc289hvm.2 
ENSMUST00000161397.2 Gm15562 ENSMUST00000161397.2 Gm15562 (from geneSymbol) ENSMUST00000161397.1 KY467696 uc057ksc.1 uc057ksc.2 uc057ksc.1 uc057ksc.2 
ENSMUST00000161401.2 Cycs ENSMUST00000161401.2 cytochrome c, somatic (from RefSeq NM_007808.5) CYCS Cycs ENSMUST00000161401.1 NM_007808 Q56A15 Q56A15_MOUSE uc009bxc.1 uc009bxc.2 uc009bxc.3 Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Mitochondrion intermembrane space Binds 1 heme group per subunit. Belongs to the cytochrome c family. mitochondrion electron carrier activity heme binding electron transport chain metal ion binding oxidation-reduction process respiratory chain uc009bxc.1 uc009bxc.2 uc009bxc.3 
ENSMUST00000161407.2 Gm15641 ENSMUST00000161407.2 Gm15641 (from geneSymbol) ENSMUST00000161407.1 uc289mry.1 uc289mry.2 uc289mry.1 uc289mry.2 
ENSMUST00000161416.2 Gm16333 ENSMUST00000161416.2 Gm16333 (from geneSymbol) ENSMUST00000161416.1 uc290sfj.1 uc290sfj.2 uc290sfj.1 uc290sfj.2 
ENSMUST00000161429.3 Dipk1c ENSMUST00000161429.3 divergent protein kinase domain 1C, transcript variant 2 (from RefSeq NM_001408327.1) DIK1C_MOUSE ENSMUST00000161429.1 ENSMUST00000161429.2 Fam69c NM_001408327 Q8BQT2 uc289pvo.1 uc289pvo.2 uc289pvo.3 Endoplasmic reticulum membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BQT2-1; Sequence=Displayed; Name=2; IsoId=Q8BQT2-2; Sequence=VSP_039089; Mainly expressed in the brain and eye, some expression in kidney and skeletal muscle. Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds. Belongs to the DIPK family. Sequence=AAI19041.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI19043.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component endoplasmic reticulum endoplasmic reticulum membrane biological_process membrane integral component of membrane uc289pvo.1 uc289pvo.2 uc289pvo.3 
ENSMUST00000161430.8 Ttc16 ENSMUST00000161430.8 tetratricopeptide repeat domain 16, transcript variant 1 (from RefSeq NM_177384.3) E9PZ84 E9PZ84_MOUSE ENSMUST00000161430.1 ENSMUST00000161430.2 ENSMUST00000161430.3 ENSMUST00000161430.4 ENSMUST00000161430.5 ENSMUST00000161430.6 ENSMUST00000161430.7 NM_177384 Ttc16 uc008jgv.1 uc008jgv.2 uc008jgv.3 uc008jgv.4 uc008jgv.5 uc008jgv.1 uc008jgv.2 uc008jgv.3 uc008jgv.4 uc008jgv.5 
ENSMUST00000161431.3 B3gat1 ENSMUST00000161431.3 Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo- fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl- sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. (from UniProt Q9CW73) AK220561 B3GA1_MOUSE B3gat1 ENSMUST00000161431.1 ENSMUST00000161431.2 Q6PIG8 Q8BXN8 Q8R531 Q9CW73 uc009opo.1 uc009opo.2 uc009opo.3 uc009opo.4 Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo- fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl- sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. Reaction=3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D- xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl- [protein] + H(+) + UDP; Xref=Rhea:RHEA:24168, Rhea:RHEA-COMP:12571, Rhea:RHEA-COMP:12573, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132090, ChEBI:CHEBI:132093; EC=2.4.1.135; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Homodimer. Interacts with SAR1A. [Isoform 1]: Golgi apparatus membrane ; Single-pass type II membrane protein Secreted [Isoform 2]: Golgi apparatus membrane ; Single-pass type II membrane protein Endoplasmic reticulum membrane Secreted Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=sGlcAT-P ; IsoId=Q9CW73-1; Sequence=Displayed; Name=2; Synonyms=lGlcAT-P ; IsoId=Q9CW73-2; Sequence=VSP_058539; The soluble form derives from the membrane form by proteolytic processing. Belongs to the glycosyltransferase 43 family. Sequence=BAC31996.1; Type=Erroneous initiation; Evidence=; Golgi membrane extracellular region endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus protein glycosylation UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity membrane integral component of membrane transferase activity intracellular membrane-bounded organelle metal ion binding chondroitin sulfate proteoglycan biosynthetic process cellular response to hypoxia uc009opo.1 uc009opo.2 uc009opo.3 uc009opo.4 
ENSMUST00000161445.8 Ppp3cb ENSMUST00000161445.8 protein phosphatase 3, catalytic subunit, beta isoform, transcript variant 2 (from RefSeq NM_001310426.1) E0CZ78 E0CZ78_MOUSE ENSMUST00000161445.1 ENSMUST00000161445.2 ENSMUST00000161445.3 ENSMUST00000161445.4 ENSMUST00000161445.5 ENSMUST00000161445.6 ENSMUST00000161445.7 NM_001310426 Ppp3cb uc007sjy.1 uc007sjy.2 uc007sjy.3 uc007sjy.4 uc007sjy.5 Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence= Name=Fe(3+); Xref=ChEBI:CHEBI:29034; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Belongs to the PPP phosphatase family. PP-2B subfamily. phosphoprotein phosphatase activity protein dephosphorylation hydrolase activity uc007sjy.1 uc007sjy.2 uc007sjy.3 uc007sjy.4 uc007sjy.5 
ENSMUST00000161448.8 Zfp316 ENSMUST00000161448.8 zinc finger protein 316 (from RefSeq NM_017467.3) ENSMUST00000161448.1 ENSMUST00000161448.2 ENSMUST00000161448.3 ENSMUST00000161448.4 ENSMUST00000161448.5 ENSMUST00000161448.6 ENSMUST00000161448.7 G3XA34 G3XA34_MOUSE NM_017467 Zfp316 uc009ajw.1 uc009ajw.2 uc009ajw.3 uc009ajw.4 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009ajw.1 uc009ajw.2 uc009ajw.3 uc009ajw.4 
ENSMUST00000161459.8 Setdb2 ENSMUST00000161459.8 SET domain, bifurcated 2, transcript variant 3 (from RefSeq NR_135463.1) B2RXP3 B2RXP3_MOUSE ENSMUST00000161459.1 ENSMUST00000161459.2 ENSMUST00000161459.3 ENSMUST00000161459.4 ENSMUST00000161459.5 ENSMUST00000161459.6 ENSMUST00000161459.7 NR_135463 Setdb2 uc011zmt.1 uc011zmt.2 uc011zmt.3 uc011zmt.4 Reaction=N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L- methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60288, Rhea:RHEA- COMP:15538, Rhea:RHEA-COMP:15541, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961, ChEBI:CHEBI:61976; EC=2.1.1.366; Evidence=; Chromosome Nucleus mitotic cell cycle DNA binding nucleus nucleoplasm chromosome cytosol chromosome segregation zinc ion binding histone-lysine N-methyltransferase activity histone lysine methylation histone methyltransferase activity (H3-K9 specific) histone H3-K9 methylation uc011zmt.1 uc011zmt.2 uc011zmt.3 uc011zmt.4 
ENSMUST00000161473.2 Gm16110 ENSMUST00000161473.2 Gm16110 (from geneSymbol) ENSMUST00000161473.1 uc290tmd.1 uc290tmd.2 uc290tmd.1 uc290tmd.2 
ENSMUST00000161475.2 Spopfm2 ENSMUST00000161475.2 speckle-type BTB/POZ protein family member 2 (from RefSeq NM_001146107.1) ENSMUST00000161475.1 Gm10696 NM_001146107 Q3UTC4 Q3UTC4_MOUSE Spopfm2 Tdpoz1 uc008qfr.1 uc008qfr.2 Belongs to the Tdpoz family. nucleus cytoplasm ubiquitin-dependent protein catabolic process regulation of proteolysis ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process uc008qfr.1 uc008qfr.2 
ENSMUST00000161490.8 Prkg2 ENSMUST00000161490.8 protein kinase, cGMP-dependent, type II (from RefSeq NM_008926.4) ENSMUST00000161490.1 ENSMUST00000161490.2 ENSMUST00000161490.3 ENSMUST00000161490.4 ENSMUST00000161490.5 ENSMUST00000161490.6 ENSMUST00000161490.7 NM_008926 Prkg2 Q8CAH8 Q8CAH8_MOUSE uc008ygj.1 uc008ygj.2 uc008ygj.3 uc008ygj.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.12; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.12; Evidence= Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity cGMP-dependent protein kinase activity ATP binding protein phosphorylation membrane kinase activity phosphorylation transferase activity cGMP binding nuclear membrane peptidyl-serine autophosphorylation protein homodimerization activity protein localization to plasma membrane negative regulation of chloride transport uc008ygj.1 uc008ygj.2 uc008ygj.3 uc008ygj.4 
ENSMUST00000161502.2 Fut10 ENSMUST00000161502.2 fucosyltransferase 10, transcript variant 1 (from RefSeq NM_001286422.2) ENSMUST00000161502.1 FUT10_MOUSE Fut10 NM_001286422 Q5F2L2 Q8C457 Q8K0S3 Q8R247 uc009ljl.1 uc009ljl.2 uc009ljl.3 uc009ljl.4 Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. Postulated to generate core alpha(1->3)-fucose epitope within the chitobiose unit of biantennary N-glycans, providing for a recognition signal to reorient aberrantly folded glycoproteins for degradation (By similarity). Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (PubMed:23986452). Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Golgi apparatus membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Fut10A; IsoId=Q5F2L2-1; Sequence=Displayed; Name=2; IsoId=Q5F2L2-2; Sequence=VSP_027509; Name=3; IsoId=Q5F2L2-3; Sequence=VSP_027507, VSP_027508; Widely expressed, with a higher expression in liver and thymus. Expressed by Lewis X-positive neural precursor cells in the ventricular and subventricular zones of 15.5 dpc embryonic brain. Belongs to the glycosyltransferase 10 family. Name=Functional Glycomics Gateway - GTase; Note=Fucosyltransferase 10; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_617"; Golgi membrane nucleoplasm endoplasmic reticulum Golgi apparatus protein glycosylation fucosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups cerebral cortex radially oriented cell migration Golgi cisterna membrane fucosylation alpha-(1->3)-fucosyltransferase activity neuronal stem cell population maintenance uc009ljl.1 uc009ljl.2 uc009ljl.3 uc009ljl.4 
ENSMUST00000161509.4 4930486I03Rik ENSMUST00000161509.4 RIKEN cDNA 4930486I03 gene (from RefSeq NR_045734.1) ENSMUST00000161509.1 ENSMUST00000161509.2 ENSMUST00000161509.3 NR_045734 uc029qnd.1 uc029qnd.2 uc029qnd.3 uc029qnd.4 uc029qnd.1 uc029qnd.2 uc029qnd.3 uc029qnd.4 
ENSMUST00000161515.8 Cnot11 ENSMUST00000161515.8 Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function (By similarity). (from UniProt Q9CWN7) BC049091 CNO11_MOUSE D1Bwg0212e ENSMUST00000161515.1 ENSMUST00000161515.2 ENSMUST00000161515.3 ENSMUST00000161515.4 ENSMUST00000161515.5 ENSMUST00000161515.6 ENSMUST00000161515.7 Q3TJG9 Q9CWN7 uc007ati.1 uc007ati.2 uc007ati.3 uc007ati.4 Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function (By similarity). Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docke to the CNOT1 scaffold (By similarity). Cytoplasm Nucleus Belongs to the CNOT11 family. molecular_function nucleus cytoplasm regulation of translation biological_process CCR4-NOT complex gene silencing by RNA uc007ati.1 uc007ati.2 uc007ati.3 uc007ati.4 
ENSMUST00000161540.3 Gm17017 ENSMUST00000161540.3 Gm17017 (from geneSymbol) ENSMUST00000161540.1 ENSMUST00000161540.2 uc287jxo.1 uc287jxo.2 uc287jxo.3 uc287jxo.1 uc287jxo.2 uc287jxo.3 
ENSMUST00000161553.2 Parp4 ENSMUST00000161553.2 poly (ADP-ribose) polymerase family, member 4 (from RefSeq NM_001145978.2) E9PYK3 ENSMUST00000161553.1 Kiaa0177 NM_001145978 PARP4_MOUSE Parp4 Q6A0B1 Q80UW6 Q8BW82 Q8R3A5 uc007ucd.1 uc007ucd.2 uc007ucd.3 uc007ucd.4 Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins. Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA- COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=; Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence=; Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Cytoplasm Nucleus Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1- dependent manner. No visible phenotype (PubMed:15169895). Mice are viable and fertile for up to five generations, with no apparent changes in telomerase activity or telomere length (PubMed:15169895). Belongs to the ARTD/PARP family. Sequence=BAD32185.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; NAD+ ADP-ribosyltransferase activity nucleus cytoplasm spindle cytosol spindle microtubule cellular protein modification process protein ADP-ribosylation inflammatory response cell death transferase activity transferase activity, transferring glycosyl groups enzyme binding regulation of telomerase activity protein ADP-ribosylase activity telomere maintenance via telomerase uc007ucd.1 uc007ucd.2 uc007ucd.3 uc007ucd.4 
ENSMUST00000161565.3 Vmn2r-ps111 ENSMUST00000161565.3 Vmn2r-ps111 (from geneSymbol) ENSMUST00000161565.1 ENSMUST00000161565.2 uc288tox.1 uc288tox.2 uc288tox.1 uc288tox.2 
ENSMUST00000161567.8 Pam ENSMUST00000161567.8 peptidylglycine alpha-amidating monooxygenase, transcript variant 9 (from RefSeq NM_001420991.1) E9Q704 E9Q704_MOUSE ENSMUST00000161567.1 ENSMUST00000161567.2 ENSMUST00000161567.3 ENSMUST00000161567.4 ENSMUST00000161567.5 ENSMUST00000161567.6 ENSMUST00000161567.7 NM_001420991 Pam uc007cfq.1 uc007cfq.2 uc007cfq.3 Reaction=a [peptide]-C-terminal (2S)-2-hydroxyglycine = a [peptide]-C- terminal amide + glyoxylate; Xref=Rhea:RHEA:20924, Rhea:RHEA- COMP:13485, Rhea:RHEA-COMP:15321, ChEBI:CHEBI:36655, ChEBI:CHEBI:137001, ChEBI:CHEBI:142768; EC=4.3.2.5; Evidence=; Reaction=a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L- ascorbate radical; Xref=Rhea:RHEA:21452, Rhea:RHEA-COMP:13486, Rhea:RHEA-COMP:15321, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:38290, ChEBI:CHEBI:59513, ChEBI:CHEBI:137000, ChEBI:CHEBI:142768; EC=1.14.17.3; Evidence=; Name=Cu(2+); Xref=ChEBI:CHEBI:29036; Evidence=; Note=Binds 2 Cu(2+) ions per subunit. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds one Zn(2+) ion per subunit. Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein In the C-terminal section; belongs to the peptidyl-alpha- hydroxyglycine alpha-amidating lyase family. In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family. catalytic activity monooxygenase activity copper ion binding peptide metabolic process membrane integral component of membrane oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen oxidation-reduction process uc007cfq.1 uc007cfq.2 uc007cfq.3 
ENSMUST00000161568.8 Tmem167 ENSMUST00000161568.8 transmembrane protein 167 (from RefSeq NM_025335.4) ENSMUST00000161568.1 ENSMUST00000161568.2 ENSMUST00000161568.3 ENSMUST00000161568.4 ENSMUST00000161568.5 ENSMUST00000161568.6 ENSMUST00000161568.7 KISHA_MOUSE NM_025335 Q8R3W3 Q9CR64 Q9CZU1 Tmem167a uc007rjo.1 uc007rjo.2 uc007rjo.3 uc007rjo.4 Involved in the early part of the secretory pathway. Golgi apparatus membrane ; Single- pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CR64-1; Sequence=Displayed; Name=2; IsoId=Q9CR64-2; Sequence=VSP_020044; Belongs to the KISH family. Golgi membrane molecular_function Golgi apparatus protein secretion membrane integral component of membrane intracellular transport uc007rjo.1 uc007rjo.2 uc007rjo.3 uc007rjo.4 
ENSMUST00000161571.3 Gm16137 ENSMUST00000161571.3 Gm16137 (from geneSymbol) ENSMUST00000161571.1 ENSMUST00000161571.2 uc288xqq.1 uc288xqq.2 uc288xqq.1 uc288xqq.2 
ENSMUST00000161576.8 Herpud1 ENSMUST00000161576.8 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1, transcript variant 1 (from RefSeq NM_022331.2) ENSMUST00000161576.1 ENSMUST00000161576.2 ENSMUST00000161576.3 ENSMUST00000161576.4 ENSMUST00000161576.5 ENSMUST00000161576.6 ENSMUST00000161576.7 HERP1_MOUSE NM_022331 Q9JJK5 uc009mwg.1 uc009mwg.2 uc009mwg.3 Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway. Interacts with PSEN1 and PSEN2 (By similarity). Interacts with UBXN6 (By similarity). Interacts with UBQLN1, UBQLN2 and UBQLN4 (By similarity). Component of the HRD1 complex, which comprises at least SYNV1/HRD1, FAM8A1, HERPUD1/HERP, OS9, SEL1L and UBE2J1. FAM8A1 binding to SYNV1 may promote recruitment of HERPUD1 to the HRD1 complex (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein protein binding endoplasmic reticulum endoplasmic reticulum membrane ubiquitin-dependent protein catabolic process cellular calcium ion homeostasis response to unfolded protein membrane integral component of membrane protein ubiquitination endoplasmic reticulum unfolded protein response retrograde protein transport, ER to cytosol regulation of protein ubiquitination endoplasmic reticulum calcium ion homeostasis response to endoplasmic reticulum stress negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ion channel binding regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of ER-associated ubiquitin-dependent protein catabolic process positive regulation of ER-associated ubiquitin-dependent protein catabolic process Lewy body core protein binding, bridging involved in substrate recognition for ubiquitination negative regulation of intrinsic apoptotic signaling pathway calcium channel complex uc009mwg.1 uc009mwg.2 uc009mwg.3 
ENSMUST00000161579.2 Gm16577 ENSMUST00000161579.2 Gm16577 (from geneSymbol) ENSMUST00000161579.1 uc287pnp.1 uc287pnp.2 uc287pnp.1 uc287pnp.2 
ENSMUST00000161581.3 Gm1992 ENSMUST00000161581.3 Gm1992 (from geneSymbol) ENSMUST00000161581.1 ENSMUST00000161581.2 uc287gdi.1 uc287gdi.2 uc287gdi.3 uc287gdi.1 uc287gdi.2 uc287gdi.3 
ENSMUST00000161583.2 2810442N19Rik ENSMUST00000161583.2 RIKEN cDNA 2810442N19 gene (from RefSeq NR_040562.1) ENSMUST00000161583.1 NR_040562 uc007dgc.1 uc007dgc.2 uc007dgc.1 uc007dgc.2 
ENSMUST00000161592.8 Eapp ENSMUST00000161592.8 E2F-associated phosphoprotein, transcript variant 1 (from RefSeq NM_025456.4) EAPP_MOUSE ENSMUST00000161592.1 ENSMUST00000161592.2 ENSMUST00000161592.3 ENSMUST00000161592.4 ENSMUST00000161592.5 ENSMUST00000161592.6 ENSMUST00000161592.7 NM_025456 Q5BU09 Q9CZB5 Q9D914 uc007nnu.1 uc007nnu.2 uc007nnu.3 May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression (By similarity). Interacts with E2F1. The C-terminal half binds the N-terminal of E2F1. Also interacts with E2F2 and E2F3, but not E2F4. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5BU09-1; Sequence=Displayed; Name=2; IsoId=Q5BU09-2; Sequence=VSP_015331; molecular_function nucleus cytoplasm positive regulation of cell proliferation positive regulation of transcription elongation from RNA polymerase II promoter negative regulation of transcription elongation from RNA polymerase II promoter uc007nnu.1 uc007nnu.2 uc007nnu.3 
ENSMUST00000161597.2 Gm15680 ENSMUST00000161597.2 Gm15680 (from geneSymbol) ENSMUST00000161597.1 uc292cnu.1 uc292cnu.2 uc292cnu.1 uc292cnu.2 
ENSMUST00000161600.8 Hycc2 ENSMUST00000161600.8 hyccin PI4KA lipid kinase complex subunit 2, transcript variant 2 (from RefSeq NM_172513.3) D1Ertd53e ENSMUST00000161600.1 ENSMUST00000161600.2 ENSMUST00000161600.3 ENSMUST00000161600.4 ENSMUST00000161600.5 ENSMUST00000161600.6 ENSMUST00000161600.7 Fam126b HYCC2_MOUSE NM_172513 Q3UMY7 Q6NV64 Q8C729 uc007bci.1 uc007bci.2 uc007bci.3 uc007bci.4 Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2). Cytoplasm, cytosol Cell membrane Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C729-1; Sequence=Displayed; Name=2; IsoId=Q8C729-2; Sequence=VSP_035078; Expressed in the central nervous system. Expressed at much lower level in oligodendrocytes than in neurons. Belongs to the Hyccin family. molecular_function cytoplasm cytosol plasma membrane membrane phosphatidylinositol phosphorylation protein localization to plasma membrane uc007bci.1 uc007bci.2 uc007bci.3 uc007bci.4 
ENSMUST00000161609.8 Rc3h1 ENSMUST00000161609.8 RING CCCH (C3H) domains 1 (from RefSeq NM_001024952.2) B2RS13 ENSMUST00000161609.1 ENSMUST00000161609.2 ENSMUST00000161609.3 ENSMUST00000161609.4 ENSMUST00000161609.5 ENSMUST00000161609.6 ENSMUST00000161609.7 Gm551 Kiaa2025 NM_001024952 Q4VGL6 Q69Z31 RC3H1_MOUSE Rc3h1 uc007del.1 uc007del.2 uc007del.3 uc007del.4 Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:23663784, PubMed:25026077, PubMed:18172933). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (PubMed:26000482). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (PubMed:20412057, PubMed:20639877). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4/Ox40 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (PubMed:23583642, PubMed:23583643, PubMed:15917799). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (PubMed:25282160). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (PubMed:27010430). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (PubMed:29244194). Able to interact with double- stranded RNA (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains. Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with DDX6 and EDC4 (PubMed:20639877, PubMed:23583643). Interacts with CCR4-NOT deadenylase complex (PubMed:23663784). Interacts with RC3H1; the interaction is RNA independent (PubMed:25697406). Q4VGL6; Q8CJG0: Ago2; NbExp=2; IntAct=EBI-2366263, EBI-528299; Q4VGL6; Q3UJB9: Edc4; NbExp=3; IntAct=EBI-2366263, EBI-2553526; Cytoplasm, P-body toplasmic granule Note=During stress, such as that induced by arsenite treatment, localizes to cytosolic stress granules (PubMed:26000482). Localization to stress granules, but not to P- bodies, depends upon the RING-type zinc finger. ICOS repression may correlate with the localization to P-bodies, not to stress granules (PubMed:20639877). Widely expressed, with highest levels in lymph node and thymus and slightly lesser amounts in brain, lung, and spleen (at protein level) (PubMed:23583643). Very weak expression in heart, muscle, and kidney (at protein level) (PubMed:23583643). Expressed in CD4(+) helper T-cells (at protein level) (PubMed:29244194, PubMed:15917799, PubMed:23583643). The ROQ region is required for CDE RNA-binding (PubMed:27010430, PubMed:25026077, PubMed:23663784). Has 2 separate RNA-binding sites, one for CDE RNA and the other for dsRNA, both sites are important for mRNA decay (By similarity). ADE RNA-binding involves an extended binding surface on the ROQ region with a number of additional residues compared with the CDE RNA (PubMed:27010430). It may also be involved in localization to stress granules (PubMed:20412057, PubMed:23583642). The RING-type zinc finger may be required for proper localization to stress granules, but not to P-bodies. HEPN (higher eukaryotes and prokaryotes nucleotide-binding) are observed in both N- and C-terminal sides of ROQ domain with 3D structure even if they are poredcted on the basis of sequence. Proteolytically cleaved after Arg-510 and Arg-579 by MALT1 in activated CD4(+) T cells; cleavage at Arg-510 and Arg-579 is critical for promoting RC3H1 degradation in response to T-cell receptor (TCR) stimulation, and hence is necessary for prolonging the stability of a set of mRNAs controlling Th17 cell differentiation. Mutant animals are born at Mendelian ratio, but die within 6 hours after birth. They displayed a curly tail and malformations of the caudal spinal column. Lethality can be rescued by changing the genetic background from C57BL/6 to outbred CD1, which allows about 4% of the animals to survive to adulthood. These animals display enlarged spleens with a trend toward increased numbers of eosinophils and monocytic/macrophage populations, dramatic and selective expansion of CD8(+) effector-like T-cells. Splenic follicular organization is normal, and the numbers of CD4(+) T-cell subtypes and B-cells are not significantly altered. No spontaneous germinal center formation, autoantibody production, nor autoimmune tissue damage. Ablation of Rc3h1 gene in the T lineage leads to elevated ICOS levels and expansion of effector CD8(+) T-cells, but not autoimmunity (PubMed:21844204). Mice lacking both Rc3h1 and Rc3h2 genes in CD4(+) T- cells develop lymphadenopathy and splenomegaly with increased spleen weight and cellularity, already at young age. They show a prominent lung pathology with a progressive reduction in the alveolar space concomitant with inflammation. They show an average survival of 130 days. CD4(+) T-cells of these mutants show a pronounced bias toward Th17 differentiation (PubMed:21844204, PubMed:23583643). Treatment of C57BL/6 males with ethylnitrosourea led to the identification of the sanroque mouse strain. The causative mutation in sanroque appears to be RC3H1 Arg-199. Homozygous sanroque mice develop high titers of autoantibodies and display excessive numbers of follicular helper T-cells and germinal centers with pattern of pathology consistent with lupus (PubMed:15917799). Sanroque mice reproducibly develop intestinal inflammation in the small intestine but not the colon. Extensive cytokine dysregulation resulting in both over- expression and under-expression of chemotactic cytokines occurs in the ileum, the region most prone to the development of inflammation in sanroque mice (PubMed:23451046). They show up-regulation of expression of at least 15 miRNAs in T cells (PubMed:25697406). The lack of compensation of RC3H1 defects by the RC3H2 paralog in sanroque mice may be due to the fact that the mutated protein may retain its scaffolding position within RNA granules, preventing RC3H2 to access mRNAs to be regulated (PubMed:23583642). Sequence=BAD32613.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein polyubiquitination nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay P-body nuclear-transcribed mRNA catabolic process B cell homeostasis regulation of germinal center formation negative regulation of germinal center formation RNA binding double-stranded RNA binding mRNA binding mRNA 3'-UTR binding ubiquitin-protein transferase activity protein binding cytoplasm zinc ion binding regulation of gene expression cytoplasmic stress granule posttranscriptional regulation of gene expression protein ubiquitination transferase activity negative regulation of B cell proliferation cytoplasmic mRNA processing body assembly miRNA binding RNA stem-loop binding T cell proliferation regulation of T cell proliferation T cell homeostasis regulation of mRNA stability negative regulation of T-helper cell differentiation negative regulation of activated T cell proliferation metal ion binding lymph node development spleen development T cell receptor signaling pathway regulation of T cell receptor signaling pathway regulation of T cell activation positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization T follicular helper cell differentiation cellular response to interleukin-1 positive regulation of NIK/NF-kappaB signaling negative regulation of T-helper 17 cell differentiation regulation of miRNA metabolic process uc007del.1 uc007del.2 uc007del.3 uc007del.4 
ENSMUST00000161611.8 Prg4 ENSMUST00000161611.8 proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein), transcript variant 1 (from RefSeq NM_021400.3) E0CZ58 E0CZ58_MOUSE ENSMUST00000161611.1 ENSMUST00000161611.2 ENSMUST00000161611.3 ENSMUST00000161611.4 ENSMUST00000161611.5 ENSMUST00000161611.6 ENSMUST00000161611.7 NM_021400 Prg4 uc007cyg.1 uc007cyg.2 uc007cyg.3 uc007cyg.4 scavenger receptor activity endocytosis immune response polysaccharide binding uc007cyg.1 uc007cyg.2 uc007cyg.3 uc007cyg.4 
ENSMUST00000161614.3 Gm4524 ENSMUST00000161614.3 predicted gene 4524 (from RefSeq NR_188886.1) ENSMUST00000161614.1 ENSMUST00000161614.2 NR_188886 uc289dvu.1 uc289dvu.2 uc289dvu.3 uc289dvu.1 uc289dvu.2 uc289dvu.3 
ENSMUST00000161643.2 Gm16029 ENSMUST00000161643.2 Gm16029 (from geneSymbol) AK044310 ENSMUST00000161643.1 uc288wvn.1 uc288wvn.2 uc288wvn.1 uc288wvn.2 
ENSMUST00000161649.9 Zfp957 ENSMUST00000161649.9 zinc finger protein 957 (from RefSeq NM_001033215.3) AU017455 ENSMUST00000161649.1 ENSMUST00000161649.2 ENSMUST00000161649.3 ENSMUST00000161649.4 ENSMUST00000161649.5 ENSMUST00000161649.6 ENSMUST00000161649.7 ENSMUST00000161649.8 NM_001033215 Q3UT76 Q3UT76_MOUSE Zfp957 uc007uss.1 uc007uss.2 uc007uss.3 DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc007uss.1 uc007uss.2 uc007uss.3 
ENSMUST00000161659.8 Slc33a1 ENSMUST00000161659.8 Acetyl-CoA transporter that mediates active acetyl-CoA import through the endoplasmic reticulum (ER) membrane into the ER lumen where specific ER-based acetyl-CoA:lysine acetyltransferases are responsible for the acetylation of ER-based protein substrate, such as BACE1 (PubMed:24828632). Necessary for O-acetylation of gangliosides (PubMed:10570973). (from UniProt Q99J27) ACATN_MOUSE Acatn BC063104 ENSMUST00000161659.1 ENSMUST00000161659.2 ENSMUST00000161659.3 ENSMUST00000161659.4 ENSMUST00000161659.5 ENSMUST00000161659.6 ENSMUST00000161659.7 Q99J27 Q9WTN1 uc290fqg.1 uc290fqg.2 Acetyl-CoA transporter that mediates active acetyl-CoA import through the endoplasmic reticulum (ER) membrane into the ER lumen where specific ER-based acetyl-CoA:lysine acetyltransferases are responsible for the acetylation of ER-based protein substrate, such as BACE1 (PubMed:24828632). Necessary for O-acetylation of gangliosides (PubMed:10570973). Reaction=acetyl-CoA(in) = acetyl-CoA(out); Xref=Rhea:RHEA:75039, ChEBI:CHEBI:57288; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75040; Evidence=; Homodimerizes. Endoplasmic reticulum membrane ; Multi-pass membrane protein Expressed in all adult tissues examined including brain, heart, kidney, liver and spleen, with maximum expression in liver and kidney. Highly expressed at day 7 of embryonic development. Detected at lower levels throughout the later stages of embryonic development. Expression is induced in presence of ceramide. Belongs to the SLC33A transporter family. endoplasmic reticulum endoplasmic reticulum membrane acetyl-CoA transporter activity solute:proton symporter activity acetyl-CoA transport membrane integral component of membrane BMP signaling pathway SMAD protein signal transduction hydrogen ion transmembrane transport uc290fqg.1 uc290fqg.2 
ENSMUST00000161664.3 Runx2os2 ENSMUST00000161664.3 Runx2os2 (from geneSymbol) AK020639 ENSMUST00000161664.1 ENSMUST00000161664.2 uc057kxx.1 uc057kxx.2 uc057kxx.3 uc057kxx.1 uc057kxx.2 uc057kxx.3 
ENSMUST00000161681.2 Gm15758 ENSMUST00000161681.2 Gm15758 (from geneSymbol) ENSMUST00000161681.1 uc291zxu.1 uc291zxu.2 uc291zxu.1 uc291zxu.2 
ENSMUST00000161684.8 Fxyd5 ENSMUST00000161684.8 Belongs to the FXYD family. (from UniProt Q3TDW1) AK170810 ENSMUST00000161684.1 ENSMUST00000161684.2 ENSMUST00000161684.3 ENSMUST00000161684.4 ENSMUST00000161684.5 ENSMUST00000161684.6 ENSMUST00000161684.7 Fxyd5 Q3TDW1 Q3TDW1_MOUSE uc009ghq.1 uc009ghq.2 uc009ghq.3 uc009ghq.4 uc009ghq.5 Belongs to the FXYD family. ion transport membrane integral component of membrane regulation of ion transport ion channel regulator activity uc009ghq.1 uc009ghq.2 uc009ghq.3 uc009ghq.4 uc009ghq.5 
ENSMUST00000161697.2 Pitpnm2os1 ENSMUST00000161697.2 phosphatidylinositol transfer protein, membrane-associated 2, opposite strand 1 (from RefSeq NR_045369.1) ENSMUST00000161697.1 NR_045369 uc029vog.1 uc029vog.2 uc029vog.1 uc029vog.2 
ENSMUST00000161706.4 Snhg9 ENSMUST00000161706.4 Snhg9 (from geneSymbol) AK006941 ENSMUST00000161706.1 ENSMUST00000161706.2 ENSMUST00000161706.3 uc008axx.1 uc008axx.2 uc008axx.3 uc008axx.4 uc008axx.5 uc008axx.1 uc008axx.2 uc008axx.3 uc008axx.4 uc008axx.5 
ENSMUST00000161721.2 ENSMUSG00000121467 ENSMUST00000161721.2 ENSMUSG00000121467 (from geneSymbol) ENSMUST00000161721.1 uc288tpj.1 uc288tpj.2 uc288tpj.1 uc288tpj.2 
ENSMUST00000161723.3 G930045G22Rik ENSMUST00000161723.3 G930045G22Rik (from geneSymbol) AK145307 ENSMUST00000161723.1 ENSMUST00000161723.2 uc291ekl.1 uc291ekl.2 uc291ekl.1 uc291ekl.2 
ENSMUST00000161731.5 Fmn1 ENSMUST00000161731.5 formin 1, transcript variant 3 (from RefSeq NM_001285458.1) E9Q7P6 E9Q7P6_MOUSE ENSMUST00000161731.1 ENSMUST00000161731.2 ENSMUST00000161731.3 ENSMUST00000161731.4 Fmn1 NM_001285458 uc289zii.1 uc289zii.2 Cytoplasm, cytoskeleton Nucleus Belongs to the formin homology family. Cappuccino subfamily. actin filament microtubule binding actin nucleation uc289zii.1 uc289zii.2 
ENSMUST00000161737.8 Hsd11b1 ENSMUST00000161737.8 hydroxysteroid 11-beta dehydrogenase 1, transcript variant 1 (from RefSeq NM_008288.3) ENSMUST00000161737.1 ENSMUST00000161737.2 ENSMUST00000161737.3 ENSMUST00000161737.4 ENSMUST00000161737.5 ENSMUST00000161737.6 ENSMUST00000161737.7 Hsd11b1 NM_008288 Q4JHD9 Q4JHD9_MOUSE uc007eeh.1 uc007eeh.2 uc007eeh.3 uc007eeh.4 Reaction=3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) = 3beta- hydroxy-5-androstene-7,17-dione + H(+) + NADPH; Xref=Rhea:RHEA:69440, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:81471, ChEBI:CHEBI:183808; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69441; Evidence=; Reaction=3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+); Xref=Rhea:RHEA:69452, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:183368, ChEBI:CHEBI:183808; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69453; Evidence=; Reaction=3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+); Xref=Rhea:RHEA:69456, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:79834, ChEBI:CHEBI:183809; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69457; Evidence=; Reaction=7-oxocholesterol + H(+) + NADPH = 7beta-hydroxycholesterol + NADP(+); Xref=Rhea:RHEA:68656, ChEBI:CHEBI:15378, ChEBI:CHEBI:42989, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:64294; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68657; Evidence=; Reaction=7-oxolithocholate + H(+) + NADPH = NADP(+) + ursodeoxycholate; Xref=Rhea:RHEA:47540, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78604, ChEBI:CHEBI:78605; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47541; Evidence=; Reaction=7-oxopregnenolone + H(+) + NADPH = 7beta-hydroxypregnenolone + NADP(+); Xref=Rhea:RHEA:69436, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:183806, ChEBI:CHEBI:183807; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69437; Evidence=; Reaction=NADP(+) + taurochenodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH; Xref=Rhea:RHEA:65060, ChEBI:CHEBI:9407, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:137724; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:65062; Evidence=; Reaction=NADP(+) + tauroursodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH; Xref=Rhea:RHEA:68980, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132028, ChEBI:CHEBI:137724; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68982; Evidence=; Reaction=a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + H(+) + NADPH; Xref=Rhea:RHEA:20233, ChEBI:CHEBI:15378, ChEBI:CHEBI:35349, ChEBI:CHEBI:47789, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.201; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:20235; Evidence=; Reaction=an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + H(+) + NADPH; Xref=Rhea:RHEA:11388, ChEBI:CHEBI:15378, ChEBI:CHEBI:35346, ChEBI:CHEBI:47787, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.146; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11389; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:11390; Evidence=; Reaction=chenodeoxycholate + NADP(+) = 7-oxolithocholate + H(+) + NADPH; Xref=Rhea:RHEA:53820, ChEBI:CHEBI:15378, ChEBI:CHEBI:36234, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78605; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:53822; Evidence=; Reaction=corticosterone + NADP(+) = 11-dehydrocorticosterone + H(+) + NADPH; Xref=Rhea:RHEA:42200, ChEBI:CHEBI:15378, ChEBI:CHEBI:16827, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78600; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42201; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42202; Evidence=; Reaction=glycochenodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH; Xref=Rhea:RHEA:65056, ChEBI:CHEBI:15378, ChEBI:CHEBI:36252, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:137818; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:65058; Evidence=; Reaction=glycoursodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH; Xref=Rhea:RHEA:68976, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132030, ChEBI:CHEBI:137818; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:68978; Evidence=; Homodimer. Endoplasmic reticulum membrane ; Single-pass type II membrane protein membrane integral component of membrane oxidoreductase activity oxidation-reduction process uc007eeh.1 uc007eeh.2 uc007eeh.3 uc007eeh.4 
ENSMUST00000161739.8 Phc1 ENSMUST00000161739.8 polyhomeotic 1, transcript variant 4 (from RefSeq NR_073364.2) ENSMUST00000161739.1 ENSMUST00000161739.2 ENSMUST00000161739.3 ENSMUST00000161739.4 ENSMUST00000161739.5 ENSMUST00000161739.6 ENSMUST00000161739.7 Edr Edr1 NR_073364 P70359 PHC1_MOUSE Phc1 Q64028 Q64307 Q7TT35 Q8BZ80 Rae28 uc009dox.1 uc009dox.2 uc009dox.3 uc009dox.4 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression (By similarity). Homodimer. Component of a PRC1-like complex (By similarity). Interacts with the SAM domain of SCMH1 via its SAM domain in vitro (PubMed:10653359). Interacts with RNF2 and CBX7 (PubMed:22226355). Interacts with PHC2 (PubMed:16024804). Interacts with BMI1 (PubMed:9009205). Q64028; P49138: Mapkapk2; NbExp=2; IntAct=EBI-927346, EBI-298776; Q64028; P23798: Pcgf2; NbExp=4; IntAct=EBI-927346, EBI-926857; Q64028; Q9QWH1: Phc2; NbExp=2; IntAct=EBI-927346, EBI-642357; Q64028; Q9CQJ4: Rnf2; NbExp=7; IntAct=EBI-927346, EBI-927321; Q64028; Q8K214: Scmh1; NbExp=2; IntAct=EBI-927346, EBI-445955; Nucleus. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q64028-1; Sequence=Displayed; Name=2; IsoId=Q64028-2; Sequence=VSP_004040; Name=3; IsoId=Q64028-3; Sequence=VSP_004041; Highly expressed in testis with lower levels in most other tissues. Expressed in embryonic stem cells (PubMed:22226355). Expressed ubiquitously in 8.5 dpc embryos. At 10.5 dpc, strongly expressed in pharyngeal arches and weakly expressed in heart. By 14.5 dpc, expression is detected throughout the central nervous system. By retinoic acid. sex chromatin DNA binding chromatin binding protein binding nucleus multicellular organism development zinc ion binding histone ubiquitination nuclear body PcG protein complex PRC1 complex metal ion binding cellular response to retinoic acid cellular response to leukemia inhibitory factor uc009dox.1 uc009dox.2 uc009dox.3 uc009dox.4 
ENSMUST00000161741.8 Atp5mf ENSMUST00000161741.8 ATP synthase membrane subunit f (from RefSeq NM_020582.3) ATPK_MOUSE Atp5j2 Atp5mf ENSMUST00000161741.1 ENSMUST00000161741.2 ENSMUST00000161741.3 ENSMUST00000161741.4 ENSMUST00000161741.5 ENSMUST00000161741.6 ENSMUST00000161741.7 NM_020582 P56135 Q3THX9 Q9JMF4 uc009amk.1 uc009amk.2 uc009amk.3 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). Mitochondrion. Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the ATPase F chain family. mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) mitochondrion mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex ATP biosynthetic process ion transport membrane integral component of membrane ATPase activity proton-transporting ATP synthase complex, coupling factor F(o) ATP metabolic process uc009amk.1 uc009amk.2 uc009amk.3 
ENSMUST00000161763.2 Gm10552 ENSMUST00000161763.2 Gm10552 (from geneSymbol) ENSMUST00000161763.1 uc287jxj.1 uc287jxj.2 uc287jxj.1 uc287jxj.2 
ENSMUST00000161807.8 Psme2 ENSMUST00000161807.8 proteasome (prosome, macropain) activator subunit 2 (PA28 beta), transcript variant 1 (from RefSeq NM_011190.3) ENSMUST00000161807.1 ENSMUST00000161807.2 ENSMUST00000161807.3 ENSMUST00000161807.4 ENSMUST00000161807.5 ENSMUST00000161807.6 ENSMUST00000161807.7 NM_011190 PSME2b Q5SVP3 Q5SVP3_MOUSE uc007tzg.1 uc007tzg.2 uc007tzg.3 Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Heterodimer of PSME1 and PSME2, which forms a hexameric ring. Belongs to the PA28 family. proteasome complex proteasome activator complex uc007tzg.1 uc007tzg.2 uc007tzg.3 
ENSMUST00000161819.2 Gm15629 ENSMUST00000161819.2 Gm15629 (from geneSymbol) ENSMUST00000161819.1 uc288vsa.1 uc288vsa.2 uc288vsa.1 uc288vsa.2 
ENSMUST00000161826.2 Gm38304 ENSMUST00000161826.2 Gm38304 (from geneSymbol) AK152660 ENSMUST00000161826.1 uc287nen.1 uc287nen.2 uc287nen.1 uc287nen.2 
ENSMUST00000161827.8 Gpc2 ENSMUST00000161827.8 glypican 2 cerebroglycan, transcript variant 1 (from RefSeq NM_172412.3) ENSMUST00000161827.1 ENSMUST00000161827.2 ENSMUST00000161827.3 ENSMUST00000161827.4 ENSMUST00000161827.5 ENSMUST00000161827.6 ENSMUST00000161827.7 GPC2_MOUSE NM_172412 Q8BKV1 uc009afj.1 uc009afj.2 uc009afj.3 Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity). Interacts (via heparan sulfate) with PTN; this interaction promotes neurite outgrowth through binding of PTN with chondroitin sulfate of proteoglycans, thereby releasing PTPRS of chondroitin sulfate proteoglycans (CSPGs) and leading to binding with heparan sulfate of GPC2. Interacts (heparan sulfate chain) with MDK; this interaction is inhibited by heparin followed by chondroitin sulfate E; this interaction induces GPC2 clustering through heparan sulfate chain; this interaction induces neuronal cell adhesion and neurite outgrowth (By similarity). Cell membrane ; Lipid-anchor, GPI- anchor ; Extracellular side [Secreted glypican-2]: Secreted, extracellular space Belongs to the glypican family. extracellular region extracellular space endoplasmic reticulum Golgi lumen plasma membrane smoothened signaling pathway regulation of signal transduction cell surface positive regulation of neuron projection development membrane cell migration neuron differentiation anchored component of membrane synapse anchored component of plasma membrane regulation of protein localization to membrane uc009afj.1 uc009afj.2 uc009afj.3 
ENSMUST00000161832.8 Cfap43 ENSMUST00000161832.8 Cfap43 (from geneSymbol) A0A494BB99 A0A494BB99_MOUSE BC107402 Cfap43 ENSMUST00000161832.1 ENSMUST00000161832.2 ENSMUST00000161832.3 ENSMUST00000161832.4 ENSMUST00000161832.5 ENSMUST00000161832.6 ENSMUST00000161832.7 uc289sif.1 uc289sif.2 uc289sif.1 uc289sif.2 
ENSMUST00000161837.2 Dydc1 ENSMUST00000161837.2 Belongs to the dpy-30 family. (from UniProt E0CXB0) AK006511 Dydc1 E0CXB0 E0CXB0_MOUSE ENSMUST00000161837.1 uc288snc.1 uc288snc.2 Belongs to the dpy-30 family. MLL3/4 complex Set1C/COMPASS complex uc288snc.1 uc288snc.2 
ENSMUST00000161841.2 Gm7097 ENSMUST00000161841.2 Gm7097 (from geneSymbol) ENSMUST00000161841.1 uc287rzr.1 uc287rzr.2 uc287rzr.1 uc287rzr.2 
ENSMUST00000161848.2 Gm15749 ENSMUST00000161848.2 Gm15749 (from geneSymbol) ENSMUST00000161848.1 uc290zcv.1 uc290zcv.2 uc290zcv.1 uc290zcv.2 
ENSMUST00000161855.8 Smim17 ENSMUST00000161855.8 Smim17 (from geneSymbol) A0A504 A0A504_MOUSE AK046418 ENSMUST00000161855.1 ENSMUST00000161855.2 ENSMUST00000161855.3 ENSMUST00000161855.4 ENSMUST00000161855.5 ENSMUST00000161855.6 ENSMUST00000161855.7 Gm16532 Olfr1344 Smim17 uc291lbt.1 uc291lbt.2 molecular_function cellular_component biological_process membrane integral component of membrane uc291lbt.1 uc291lbt.2 
ENSMUST00000161859.8 Rnf6 ENSMUST00000161859.8 ring finger protein (C3H2C3 type) 6, transcript variant 1 (from RefSeq NM_028774.3) B2RRR0 ENSMUST00000161859.1 ENSMUST00000161859.2 ENSMUST00000161859.3 ENSMUST00000161859.4 ENSMUST00000161859.5 ENSMUST00000161859.6 ENSMUST00000161859.7 NM_028774 Q8K565 Q9DBU5 RNF6_MOUSE Rnf6 uc009anc.1 uc009anc.2 uc009anc.3 uc009anc.4 uc009anc.5 E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation (PubMed:16204183). Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover (PubMed:16204183). Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity (By similarity). May also bind DNA and function as a transcriptional regulator (PubMed:11971979). Mediates polyubiquitination of QKI in macrophages, leading to its degradation (PubMed:36088389). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence= Protein modification; protein ubiquitination. Nucleus Cytoplasm Cell projection, axon Nucleus, PML body Note=Localizes to the PML nuclear bodies in Sertoli cells. Widely expressed with higher expression in the testis in both germ cells and Sertoli cells. Expressed in the floor plate and ventral portions of the developing neural tube of 12.5 dpc to 13 dpc mouse embryos. Found in developing neuronal projections (at protein level). Belongs to the RNF12 family. DNA binding ubiquitin-protein transferase activity protein binding nucleus cytoplasm regulation of transcription, DNA-templated ubiquitin-dependent protein catabolic process protein ubiquitination PML body transferase activity axon negative regulation of axon extension nuclear membrane cell projection intracellular membrane-bounded organelle protein K27-linked ubiquitination positive regulation of transcription, DNA-templated metal ion binding androgen receptor binding regulation of androgen receptor signaling pathway ubiquitin protein ligase activity protein K48-linked ubiquitination protein K6-linked ubiquitination uc009anc.1 uc009anc.2 uc009anc.3 uc009anc.4 uc009anc.5 
ENSMUST00000161868.2 Gm16163 ENSMUST00000161868.2 predicted gene 16163 (from RefSeq NR_188797.1) ENSMUST00000161868.1 NR_188797 uc009nxr.1 uc009nxr.2 uc009nxr.1 uc009nxr.2 
ENSMUST00000161921.8 Zeb1os1 ENSMUST00000161921.8 zinc finger E-box binding homeobox 1, opposite strand 1 (from RefSeq NR_033552.1) ENSMUST00000161921.1 ENSMUST00000161921.2 ENSMUST00000161921.3 ENSMUST00000161921.4 ENSMUST00000161921.5 ENSMUST00000161921.6 ENSMUST00000161921.7 NR_033552 uc008dyv.1 uc008dyv.2 uc008dyv.3 uc008dyv.4 uc008dyv.1 uc008dyv.2 uc008dyv.3 uc008dyv.4 
ENSMUST00000161923.2 Gm16025 ENSMUST00000161923.2 Gm16025 (from geneSymbol) BC108341 ENSMUST00000161923.1 uc007btv.1 uc007btv.2 uc007btv.3 uc007btv.1 uc007btv.2 uc007btv.3 
ENSMUST00000161925.2 Gm15996 ENSMUST00000161925.2 Gm15996 (from geneSymbol) ENSMUST00000161925.1 uc288jli.1 uc288jli.2 uc288jli.1 uc288jli.2 
ENSMUST00000161939.3 Gm16311 ENSMUST00000161939.3 predicted gene 16311, transcript variant 1 (from RefSeq NR_168061.1) ENSMUST00000161939.1 ENSMUST00000161939.2 NR_168061 uc288wuc.1 uc288wuc.2 uc288wuc.3 uc288wuc.1 uc288wuc.2 uc288wuc.3 
ENSMUST00000161949.8 Pag1 ENSMUST00000161949.8 phosphoprotein associated with glycosphingolipid microdomains 1, transcript variant A (from RefSeq NM_001195031.1) Cbp ENSMUST00000161949.1 ENSMUST00000161949.2 ENSMUST00000161949.3 ENSMUST00000161949.4 ENSMUST00000161949.5 ENSMUST00000161949.6 ENSMUST00000161949.7 NM_001195031 PHAG1_MOUSE Pag Q3U1F9 Q8BFS1 Q9EQF3 uc008ope.1 uc008ope.2 uc008ope.3 uc008ope.4 Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. When phosphorylated, interacts with CSK. Interacts with NHERF1/EBP50. In resting T-cells, part of a PAG1-NHERF1-MSN complex which is disrupted upon TCR activation. Q3U1F9; P41241: Csk; NbExp=9; IntAct=EBI-8468834, EBI-2553183; Cell membrane ingle-pass type III membrane protein te=Present in lipid rafts. Present in T-cells (at protein level). Palmitoylated. Phosphorylated by FYN on Tyr-314 in resting T-cells; which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Mice are viable and do not show any developmental defect up to 20 months of age. They have normal T-cell development and normal T- and B-cell responses. adaptive immune response immune system process protein binding plasma membrane membrane integral component of membrane intracellular signal transduction SH2 domain binding membrane raft regulation of T cell activation negative regulation of T cell activation uc008ope.1 uc008ope.2 uc008ope.3 uc008ope.4 
ENSMUST00000161954.8 Nckap5 ENSMUST00000161954.8 NCK-associated protein 5, transcript variant 2 (from RefSeq NM_172484.3) E030049G20Rik ENSMUST00000161954.1 ENSMUST00000161954.2 ENSMUST00000161954.3 ENSMUST00000161954.4 ENSMUST00000161954.5 ENSMUST00000161954.6 ENSMUST00000161954.7 Erih2 NM_172484 Nckap5 Q6NZK2 Q6NZK2_MOUSE uc007ckk.1 uc007ckk.2 uc007ckk.3 microtubule bundle formation molecular_function microtubule depolymerization microtubule plus-end uc007ckk.1 uc007ckk.2 uc007ckk.3 
ENSMUST00000161972.10 Vmn2r7 ENSMUST00000161972.10 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PYL5) AK030224 E9PYL5 E9PYL5_MOUSE ENSMUST00000161972.1 ENSMUST00000161972.2 ENSMUST00000161972.3 ENSMUST00000161972.4 ENSMUST00000161972.5 ENSMUST00000161972.6 ENSMUST00000161972.7 ENSMUST00000161972.8 ENSMUST00000161972.9 H3BJT0 H3BKZ7 Vmn2r7 uc290frn.1 uc290frn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc290frn.1 uc290frn.2 
ENSMUST00000161975.3 4930473D10Rik ENSMUST00000161975.3 4930473D10Rik (from geneSymbol) AK019644 ENSMUST00000161975.1 ENSMUST00000161975.2 uc287uxf.1 uc287uxf.2 uc287uxf.3 uc287uxf.1 uc287uxf.2 uc287uxf.3 
ENSMUST00000161976.8 Myc ENSMUST00000161976.8 myelocytomatosis oncogene, transcript variant 2 (from RefSeq NM_001177354.1) A0A087WSQ0 B2RSN1 ENSMUST00000161976.1 ENSMUST00000161976.2 ENSMUST00000161976.3 ENSMUST00000161976.4 ENSMUST00000161976.5 ENSMUST00000161976.6 ENSMUST00000161976.7 F6PX41 F8WID3 MYC_MOUSE NM_001177354 P01108 P70247 Q3UM70 Q61422 uc288yha.1 uc288yha.2 The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]. Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (PubMed:31005419). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-73 and Ser-77) with FBXW7. Interacts with PIM2 (PubMed:18438430). Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity (By similarity). Interacts with TRIM6 (PubMed:22328504). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (By similarity). Interacts with CIP2A; leading to the stabilization of MYC (By similarity). P01108; P28574: Max; NbExp=7; IntAct=EBI-1183114, EBI-1183003; P01108; Q8CH72: Trim32; NbExp=2; IntAct=EBI-1183114, EBI-773837; Nucleus, nucleoplasm Nucleus, nucleolus Event=Alternative initiation; Named isoforms=3; Name=2; Synonyms=c-myc 1 ; IsoId=P01108-1; Sequence=Displayed; Name=1; Synonyms=c-myc 2 ; IsoId=P01108-2; Sequence=VSP_061781; Name=3; IsoId=P01108-3; Sequence=VSP_061782; Expressed in the intestinal epithelium (at protein level). Expressed in the proliferating cells of the developing CNS and the epidermis. At 10.5, 11.5 and 12.5 dpc, expressed in the spinal cord, within a subset of cells in the proliferative ventricular zone, as well as in the differentiating cells at the ventral portion of the intermediate zone. Also detected in the roof plate and in the neural crest. At 14.5 dpc, found in regions containing differentiating postmitotic neurons. In the developing epidermis at 14.5 dpc, found in the dorsal lateral epidermis. At 17 dpc, expression is confined primarily to the proliferative malphigian layer of the epidermis and to the dermal papilla and primary germ cells in the dermis. [Isoform 2]: Up-regulated in cultured cells as they reach high density (at protein level). [Isoform 1]: Expression levels are unaffected by cell density. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Phosphorylated by PRKDC (By similarity). Phosphorylation at Ser- 344 by PIM2 leads to the stabilization of MYC (PubMed:18438430). Phosphorylation at Ser-77 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-77 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-73. Phosphorylation at Thr- 73 and Ser-77 by GSK3 is required for ubiquitination and degradation by the proteasome. Dephosphorylation at Ser-77 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (By similarity). Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-73 and Ser-77, leading to its degradation by the proteasome. Ubiquitination is counteracted by USP28 in the nucleoplasm and USP36 in the nucleolus, both interacting with of FBXW7, leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRPC4AP) complex (By similarity). Ubiquitinated by TRIM6 in a phosphorylation-independent manner (PubMed:22328504). POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Alternative translation initiation from an upstream, in- frame non-ATG (CTG) codon or a downstream ATG start site results in the production of 2 isoforms with distinct N-termini, shown in this entry as isoforms 2/3 and isoform 1, respectively. [Isoform 2]: Produced by alternative translation initiation from a CTG codon, which is translated as Met. [Isoform 3]: Produced by alternative translation initiation from a CTG codon, which is translated as Met, and alternative splicing. Sequence=AAH06728.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter MAPK cascade re-entry into mitotic cell cycle nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding core promoter binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding branching involved in ureteric bud morphogenesis B cell apoptotic process positive regulation of mesenchymal cell proliferation regulation of oxidative phosphorylation positive regulation of B cell apoptotic process DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm nuclear euchromatin nucleolus cytoplasm mitochondrion spindle glucose metabolic process chromatin remodeling transcription, DNA-templated DNA-templated transcription, initiation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter pyruvate transport amino acid transport cellular iron ion homeostasis activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus inner mitochondrial membrane organization cell cycle arrest regulation of mitotic cell cycle transcription factor binding cell proliferation positive regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage response to radiation response to gamma radiation regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of mitochondrial membrane potential positive regulation of smooth muscle cell migration Wnt signaling pathway protein processing nuclear body transformation of host cell by virus axon ubiquitin protein ligase binding negative regulation of protein binding regulation of telomere maintenance protein-DNA complex disassembly macromolecular complex activating transcription factor binding cellular response to interferon-alpha cellular response to drug skeletal muscle cell differentiation middle ear morphogenesis regulation of apoptotic process positive regulation of catalytic activity response to alkaloid positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of DNA binding pigmentation sequence-specific DNA binding canonical Wnt signaling pathway involved in negative regulation of apoptotic process canonical Wnt signaling pathway involved in positive regulation of apoptotic process macromolecular complex binding negative regulation of monocyte differentiation positive regulation of cell cycle positive regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of glucose import lactic acid secretion protein heterodimerization activity protein dimerization activity positive regulation of fibroblast proliferation negative regulation of fibroblast proliferation perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation skeletal system morphogenesis positive regulation of epithelial cell proliferation detection of mechanical stimulus involved in sensory perception of sound chromosome organization negative regulation of cell division positive regulation of telomerase activity positive regulation of glial cell proliferation negative regulation of cell death ERK1 and ERK2 cascade repressing transcription factor binding E-box binding cellular response to hypoxia positive regulation of metanephric cap mesenchymal cell proliferation positive regulation of cellular respiration positive regulation of oxidative phosphorylation regulation of somatic stem cell population maintenance positive regulation of DNA methylation positive regulation of DNA biosynthetic process positive regulation of response to DNA damage stimulus positive regulation of ATP biosynthetic process positive regulation of apoptotic signaling pathway uc288yha.1 uc288yha.2 
ENSMUST00000161985.2 Gm16579 ENSMUST00000161985.2 Gm16579 (from geneSymbol) AK048585 ENSMUST00000161985.1 uc290wtl.1 uc290wtl.2 uc290wtl.1 uc290wtl.2 
ENSMUST00000161991.8 Tbc1d4 ENSMUST00000161991.8 TBC1 domain family, member 4, transcript variant 5 (from RefSeq NM_001404674.1) E9Q6Q8 E9Q6Q8_MOUSE ENSMUST00000161991.1 ENSMUST00000161991.2 ENSMUST00000161991.3 ENSMUST00000161991.4 ENSMUST00000161991.5 ENSMUST00000161991.6 ENSMUST00000161991.7 NM_001404674 Tbc1d4 uc007uvn.1 uc007uvn.2 uc007uvn.3 uc007uvn.4 cytosol vesicle-mediated transport negative regulation of vesicle fusion vesicle cellular response to insulin stimulus uc007uvn.1 uc007uvn.2 uc007uvn.3 uc007uvn.4 
ENSMUST00000162004.8 Hps1 ENSMUST00000162004.8 HPS1, biogenesis of lysosomal organelles complex 3 subunit 1, transcript variant 1 (from RefSeq NM_019424.3) A0A0R4J062 A0A0R4J062_MOUSE ENSMUST00000162004.1 ENSMUST00000162004.2 ENSMUST00000162004.3 ENSMUST00000162004.4 ENSMUST00000162004.5 ENSMUST00000162004.6 ENSMUST00000162004.7 Hps1 NM_019424 uc008hny.1 uc008hny.2 uc008hny.3 uc008hny.1 uc008hny.2 uc008hny.3 
ENSMUST00000162022.8 Glis3 ENSMUST00000162022.8 GLIS family zinc finger 3, transcript variant 1 (from RefSeq NM_175459.6) ENSMUST00000162022.1 ENSMUST00000162022.2 ENSMUST00000162022.3 ENSMUST00000162022.4 ENSMUST00000162022.5 ENSMUST00000162022.6 ENSMUST00000162022.7 Glis3 NM_175459 Q0GE24 Q0GE24_MOUSE uc008hci.1 uc008hci.2 uc008hci.3 This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein which contains multiple C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the transcriptional regulation of insulin. It is thought to enhance GLI-RE-dependent transcription by binding to the GLI-RE consensus sequence (GACCACCCAC). Mutations in a similar gene in human have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]. Belongs to the GLI C2H2-type zinc-finger protein family. nucleic acid binding nucleus regulation of transcription from RNA polymerase II promoter uc008hci.1 uc008hci.2 uc008hci.3 
ENSMUST00000162031.8 Txndc9 ENSMUST00000162031.8 thioredoxin domain containing 9, transcript variant 1 (from RefSeq NM_172054.5) Apacd ENSMUST00000162031.1 ENSMUST00000162031.2 ENSMUST00000162031.3 ENSMUST00000162031.4 ENSMUST00000162031.5 ENSMUST00000162031.6 ENSMUST00000162031.7 NM_172054 Q3TKD2 Q9CQ79 TXND9_MOUSE uc007asm.1 uc007asm.2 uc007asm.3 Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin. Forms ternary complexes with the chaperonin TCP1 complex, spanning the cylindrical chaperonin cavity and contacting at least 2 subunits. Cytoplasm Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody Note=Co-localizes with beta-tubulin in the centrosome. Expressed in testis, liver, heart, kidney, brain, spleen and lung. nucleus cytoplasm centrosome microtubule organizing center cytosol cytoskeleton midbody cell redox homeostasis uc007asm.1 uc007asm.2 uc007asm.3 
ENSMUST00000162036.8 Rsrc1 ENSMUST00000162036.8 Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing (By similarity). (from UniProt Q9DBU6) AK169340 ENSMUST00000162036.1 ENSMUST00000162036.2 ENSMUST00000162036.3 ENSMUST00000162036.4 ENSMUST00000162036.5 ENSMUST00000162036.6 ENSMUST00000162036.7 Q3TF06 Q9DBU6 RSRC1_MOUSE Srrp53 uc290fua.1 uc290fua.2 Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing (By similarity). Interacts (via Arg/Ser-rich domain) with LUC7L3, RBM39 and RSF1. Nucleus Nucleus speckle Cytoplasm Note=Shuttles between the nucleus and cytoplasm. Phosphorylated. alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome protein binding nucleus cytoplasm mRNA processing protein phosphorylation nucleocytoplasmic transport RNA splicing nuclear speck response to antibiotic uc290fua.1 uc290fua.2 
ENSMUST00000162041.8 Gcc2 ENSMUST00000162041.8 Membrane ; Peripheral membrane protein (from UniProt E9PWI6) BC145495 E9PWI6 E9PWI6_MOUSE ENSMUST00000162041.1 ENSMUST00000162041.2 ENSMUST00000162041.3 ENSMUST00000162041.4 ENSMUST00000162041.5 ENSMUST00000162041.6 ENSMUST00000162041.7 Gcc2 uc287rjd.1 uc287rjd.2 Membrane ; Peripheral membrane protein uc287rjd.1 uc287rjd.2 
ENSMUST00000162046.3 Vmn2r25 ENSMUST00000162046.3 vomeronasal 2, receptor 25 (from RefSeq NM_001104641.1) ENSMUST00000162046.1 ENSMUST00000162046.2 NM_001104641 Vmn2r25 W4VSP2 W4VSP2_MOUSE uc009vea.1 uc009vea.2 uc009vea.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vea.1 uc009vea.2 uc009vea.3 
ENSMUST00000162051.2 Gm15628 ENSMUST00000162051.2 Gm15628 (from geneSymbol) ENSMUST00000162051.1 uc288vrw.1 uc288vrw.2 uc288vrw.1 uc288vrw.2 
ENSMUST00000162059.6 4833413E03Rik ENSMUST00000162059.6 4833413E03Rik (from geneSymbol) AK019514 ENSMUST00000162059.1 ENSMUST00000162059.2 ENSMUST00000162059.3 ENSMUST00000162059.4 ENSMUST00000162059.5 uc008bvg.1 uc008bvg.2 uc008bvg.1 uc008bvg.2 
ENSMUST00000162097.8 Arpp21 ENSMUST00000162097.8 [Isoform 2]: May act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. (from UniProt Q9DCB4) A1A561 ARP21_MOUSE BC098368 ENSMUST00000162097.1 ENSMUST00000162097.2 ENSMUST00000162097.3 ENSMUST00000162097.4 ENSMUST00000162097.5 ENSMUST00000162097.6 ENSMUST00000162097.7 Q3UUU8 Q7TS83 Q8BLD1 Q8BWM1 Q8C018 Q8C038 Q8C0Y6 Q91Y59 Q9DCB4 Rcs Tarpp uc292lvl.1 uc292lvl.2 [Isoform 2]: May act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. Interacts with CALM1. Cytoplasm Event=Alternative splicing; Named isoforms=10; Name=1; Synonyms=TARPP; IsoId=Q9DCB4-1; Sequence=Displayed; Name=2; Synonyms=ARPP-21, RCS; IsoId=Q9DCB4-2; Sequence=VSP_029477, VSP_029478; Name=3; IsoId=Q9DCB4-3; Sequence=VSP_029485, VSP_029490; Name=4; IsoId=Q9DCB4-4; Sequence=VSP_029485, VSP_029488, VSP_029490; Name=5; IsoId=Q9DCB4-5; Sequence=VSP_029485; Name=6; IsoId=Q9DCB4-6; Sequence=VSP_029479, VSP_029480; Name=7; IsoId=Q9DCB4-7; Sequence=VSP_029487, VSP_029489; Name=8; IsoId=Q9DCB4-8; Sequence=VSP_029483, VSP_029484; Name=9; IsoId=Q9DCB4-9; Sequence=VSP_029479, VSP_029481, VSP_029491, VSP_029492; Name=10; IsoId=Q9DCB4-10; Sequence=VSP_029482, VSP_029486; [Isoform 1]: Present at high levels in thymus and low levels in brain. In thymus, isoform 1 is specifically found in immature thymocytes (at protein level). [Isoform 1]: Down-regulated in thymocytes upon TCR engagement (at protein level). Phosphorylation of isoform 2 at Ser-55 is enhanced upon dopamine D1 receptor activation and favors interaction with CALM1. [Isoform 1]: Methylated by CARM1 at Arg-650 in immature thymocytes. [Isoform 10]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. molecular_function nucleic acid binding calmodulin binding cytoplasm cellular response to heat uc292lvl.1 uc292lvl.2 
ENSMUST00000162110.8 Spata6l ENSMUST00000162110.8 spermatogenesis associated 6 like, transcript variant 4 (from RefSeq NM_001374153.1) 4430402I18Rik ENSMUST00000162110.1 ENSMUST00000162110.2 ENSMUST00000162110.3 ENSMUST00000162110.4 ENSMUST00000162110.5 ENSMUST00000162110.6 ENSMUST00000162110.7 F6UU42 F6UU42_MOUSE NM_001374153 Spata6l uc289rot.1 uc289rot.2 Belongs to the SPATA6 family. uc289rot.1 uc289rot.2 
ENSMUST00000162112.8 Greb1 ENSMUST00000162112.8 gene regulated by estrogen in breast cancer protein, transcript variant 1 (from RefSeq NM_015764.4) E0CYB3 ENSMUST00000162112.1 ENSMUST00000162112.2 ENSMUST00000162112.3 ENSMUST00000162112.4 ENSMUST00000162112.5 ENSMUST00000162112.6 ENSMUST00000162112.7 GREB1_MOUSE Kiaa0575 NM_015764 Q3UHK3 Q8BZT6 Q8CHE7 Q9JLG7 uc029rrb.1 uc029rrb.2 uc029rrb.3 May play a role in estrogen-stimulated cell proliferation. Membrane ; Single-pass membrane protein Belongs to the GREB1 family. Sequence=BAC41432.2; Type=Miscellaneous discrepancy; Note=Partially unspliced pre-RNA.; Evidence=; membrane integral component of membrane uc029rrb.1 uc029rrb.2 uc029rrb.3 
ENSMUST00000162113.2 Speer4cos ENSMUST00000162113.2 spermatogenesis associated glutamate (E)-rich protein 4C, opposite strand transcript (from RefSeq NR_001585.3) ENSMUST00000162113.1 NR_001585 uc008wms.1 uc008wms.2 uc008wms.1 uc008wms.2 
ENSMUST00000162121.2 4930480K15Rik ENSMUST00000162121.2 RIKEN cDNA 4930480K15 gene (from RefSeq NR_045463.1) ENSMUST00000162121.1 NR_045463 uc029tli.1 uc029tli.2 uc029tli.1 uc029tli.2 
ENSMUST00000162159.8 Lrrc9 ENSMUST00000162159.8 leucine rich repeat containing 9, transcript variant 1 (from RefSeq NM_001142728.1) ENSMUST00000162159.1 ENSMUST00000162159.2 ENSMUST00000162159.3 ENSMUST00000162159.4 ENSMUST00000162159.5 ENSMUST00000162159.6 ENSMUST00000162159.7 LRRC9_MOUSE NM_001142728 Q8CAD3 Q8CDN9 Q9D2J8 uc007nvn.1 uc007nvn.2 uc007nvn.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CDN9-1; Sequence=Displayed; Name=2; IsoId=Q8CDN9-2; Sequence=VSP_033992, VSP_033993; Sequence=BAB31790.1; Type=Frameshift; Evidence=; Sequence=BAC26622.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc007nvn.1 uc007nvn.2 uc007nvn.3 
ENSMUST00000162171.2 Gm16308 ENSMUST00000162171.2 predicted gene 16308 (from RefSeq NR_188867.1) ENSMUST00000162171.1 NR_188867 uc288yoc.1 uc288yoc.2 uc288yoc.1 uc288yoc.2 
ENSMUST00000162175.9 Exoc5 ENSMUST00000162175.9 exocyst complex component 5 (from RefSeq NM_207214.3) ENSMUST00000162175.1 ENSMUST00000162175.2 ENSMUST00000162175.3 ENSMUST00000162175.4 ENSMUST00000162175.5 ENSMUST00000162175.6 ENSMUST00000162175.7 ENSMUST00000162175.8 EXOC5_MOUSE NM_207214 Q3TPX4 Q80VK3 Sec10l1 uc007tjv.1 uc007tjv.2 uc007tjv.3 uc007tjv.4 Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with EXOC3L1 (PubMed:18480549). Cytoplasm Midbody Note=Localization at the midbody requires the presence of RALA, EXOC2 and EXOC3. Belongs to the SEC10 family. exocyst establishment of planar polarity cytoplasm cytosol exocytosis Golgi to plasma membrane transport protein transport Ral GTPase binding midbody protein N-terminus binding vesicle docking protein localization to plasma membrane epithelial cell apoptotic process non-motile cilium assembly uc007tjv.1 uc007tjv.2 uc007tjv.3 uc007tjv.4 
ENSMUST00000162183.8 Alg12 ENSMUST00000162183.8 ALG12 alpha-1,6-mannosyltransferase, transcript variant 7 (from RefSeq NR_183242.1) ALG12_MOUSE ENSMUST00000162183.1 ENSMUST00000162183.2 ENSMUST00000162183.3 ENSMUST00000162183.4 ENSMUST00000162183.5 ENSMUST00000162183.6 ENSMUST00000162183.7 NR_183242 Q3UQK8 Q8VDB2 uc007xeo.1 uc007xeo.2 uc007xeo.3 uc007xeo.4 Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Reaction=a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)- alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D- Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc- (1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D- Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man- (1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc- diphosphodolichol + H(+); Xref=Rhea:RHEA:29535, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, Rhea:RHEA-COMP:12629, Rhea:RHEA-COMP:12630, ChEBI:CHEBI:15378, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, ChEBI:CHEBI:132517, ChEBI:CHEBI:132519; EC=2.4.1.260; Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the glycosyltransferase 22 family. mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane protein glycosylation protein N-linked glycosylation dolichol-linked oligosaccharide biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity mannosylation uc007xeo.1 uc007xeo.2 uc007xeo.3 uc007xeo.4 
ENSMUST00000162186.3 Gm16575 ENSMUST00000162186.3 Gm16575 (from geneSymbol) AK053121 ENSMUST00000162186.1 ENSMUST00000162186.2 uc288zrr.1 uc288zrr.2 uc288zrr.3 uc288zrr.1 uc288zrr.2 uc288zrr.3 
ENSMUST00000162187.2 Mgat4f ENSMUST00000162187.2 MGAT4 family, member F (from RefSeq NM_173771.4) 4933406M09Rik ENSMUST00000162187.1 G3XA12 G3XA12_MOUSE Mgat4f NM_173771 uc007crt.1 uc007crt.2 uc007crt.3 uc007crt.4 protein N-linked glycosylation acetylglucosaminyltransferase activity uc007crt.1 uc007crt.2 uc007crt.3 uc007crt.4 
ENSMUST00000162198.2 Gm10612 ENSMUST00000162198.2 predicted gene 10612 (from RefSeq NR_166074.1) ENSMUST00000162198.1 NR_166074 uc292duc.1 uc292duc.2 uc292duc.1 uc292duc.2 
ENSMUST00000162209.2 Gm16536 ENSMUST00000162209.2 Gm16536 (from geneSymbol) ENSMUST00000162209.1 FJ573254 uc012gsi.1 uc012gsi.2 uc012gsi.3 uc012gsi.4 uc012gsi.5 uc012gsi.1 uc012gsi.2 uc012gsi.3 uc012gsi.4 uc012gsi.5 
ENSMUST00000162213.2 Gm15898 ENSMUST00000162213.2 Gm15898 (from geneSymbol) ENSMUST00000162213.1 uc292dmz.1 uc292dmz.2 uc292dmz.1 uc292dmz.2 
ENSMUST00000162218.2 4930594M22Rik ENSMUST00000162218.2 4930594M22Rik (from geneSymbol) AK019841 ENSMUST00000162218.1 uc288wqb.1 uc288wqb.2 uc288wqb.1 uc288wqb.2 
ENSMUST00000162224.9 E330034G19Rik ENSMUST00000162224.9 E330034G19Rik (from geneSymbol) AK087874 ENSMUST00000162224.1 ENSMUST00000162224.2 ENSMUST00000162224.3 ENSMUST00000162224.4 ENSMUST00000162224.5 ENSMUST00000162224.6 ENSMUST00000162224.7 ENSMUST00000162224.8 uc007sqj.1 uc007sqj.2 uc007sqj.3 uc007sqj.4 uc007sqj.1 uc007sqj.2 uc007sqj.3 uc007sqj.4 
ENSMUST00000162226.9 Zbtb37 ENSMUST00000162226.9 Zbtb37 (from geneSymbol) AK084871 ENSMUST00000162226.1 ENSMUST00000162226.2 ENSMUST00000162226.3 ENSMUST00000162226.4 ENSMUST00000162226.5 ENSMUST00000162226.6 ENSMUST00000162226.7 ENSMUST00000162226.8 Q8C3U9 Q8C3U9_MOUSE Zbtb37 uc007des.1 uc007des.2 uc007des.3 negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus uc007des.1 uc007des.2 uc007des.3 
ENSMUST00000162239.2 Gm16161 ENSMUST00000162239.2 Gm16161 (from geneSymbol) ENSMUST00000162239.1 uc291hsy.1 uc291hsy.2 uc291hsy.1 uc291hsy.2 
ENSMUST00000162246.9 Hmgn3 ENSMUST00000162246.9 high mobility group nucleosomal binding domain 3, transcript variant a (from RefSeq NM_026122.4) ENSMUST00000162246.1 ENSMUST00000162246.2 ENSMUST00000162246.3 ENSMUST00000162246.4 ENSMUST00000162246.5 ENSMUST00000162246.6 ENSMUST00000162246.7 ENSMUST00000162246.8 HMGN3_MOUSE NM_026122 Q7M737 Q99JU1 Q9DCB1 uc009qwe.1 uc009qwe.2 uc009qwe.3 uc009qwe.4 Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. Interacts with the ligand binding domain of the thyroid receptor (TR) (in vitro). Requires the presence of thyroid hormone for its interaction. Interacts with transcriptional regulator SEHBP. Interacts with nucleosomes. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=HMGN3a; IsoId=Q9DCB1-1; Sequence=Displayed; Name=2; Synonyms=HMGN3b; IsoId=Q9DCB1-2; Sequence=VSP_017909, VSP_017910; Name=3; IsoId=Q9DCB1-3; Sequence=VSP_017911, VSP_017912; Expressed in the brain, eye, prostate, thyroid, kidney, testis, glial cells and insulin-producing cells of the Langerhans pancreatic islets. In the brain, expressed in the lateral olfactory tract, anterior commissure, corpus callosum, internal capsule, fornix, stria medullans, optic tract, axon bundles, Purkinje cell layer and granular layer of the cerebellum. In retina, expressed in the nuclei of cells in the inner nuclear layer including amacrine, bipolar and horizontal neurons and in the nuclei of ganglion neurons. Detected at low levels in the liver. Transiently expressed in the stroma and endothelium of the cornea at birth. Subsequently expressed in the corneal epithelium and the inner nuclear and ganglion cell layers of the retina. The predominant form in developing ocular tissues is isoform 2, although isoform 1 is also detectable. Mice are viable and fertile. Mice have a mild diabetic phenotype and lower plasma glucagon levels. The overall shape of the islets, the location of the alpha cells in the mantle of the pancreatic islets or proliferation of pancreatic alpha cells are not affected. Belongs to the HMGN family. chromatin DNA binding chromatin binding nucleus chromatin organization regulation of transcription from RNA polymerase II promoter nucleosomal DNA binding positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity regulation of insulin secretion involved in cellular response to glucose stimulus uc009qwe.1 uc009qwe.2 uc009qwe.3 uc009qwe.4 
ENSMUST00000162269.9 Plch1 ENSMUST00000162269.9 phospholipase C, eta 1, transcript variant 3 (from RefSeq NM_001177732.2) ENSMUST00000162269.1 ENSMUST00000162269.2 ENSMUST00000162269.3 ENSMUST00000162269.4 ENSMUST00000162269.5 ENSMUST00000162269.6 ENSMUST00000162269.7 ENSMUST00000162269.8 Kiaa1069 NM_001177732 PLCH1_MOUSE Plch1 Plcl3 Q4KWH5 Q4KWH6 Q4KWH7 Q69ZS3 Q7TPQ1 Q8CFQ2 uc033htw.1 uc033htw.2 uc033htw.3 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33180; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Cytoplasm Membrane Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=PLC-eta-1; IsoId=Q4KWH5-1; Sequence=Displayed; Name=2; IsoId=Q4KWH5-2; Sequence=VSP_032908, VSP_032909, VSP_032911; Name=3; Synonyms=PLC-eta-1b; IsoId=Q4KWH5-3; Sequence=VSP_032912, VSP_032915; Name=4; Synonyms=PLC-eta-1a; IsoId=Q4KWH5-4; Sequence=VSP_032913, VSP_032914; Name=5; IsoId=Q4KWH5-5; Sequence=VSP_032907, VSP_032910, VSP_032911, VSP_032912, VSP_032915; Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord. phosphatidylinositol phospholipase C activity calcium ion binding cytoplasm cytosol lipid metabolic process signal transduction phosphoric diester hydrolase activity membrane lipid catabolic process hydrolase activity inositol trisphosphate biosynthetic process intracellular signal transduction intracellular membrane-bounded organelle metal ion binding phosphatidylinositol-mediated signaling calcium-dependent phospholipase C activity release of sequestered calcium ion into cytosol uc033htw.1 uc033htw.2 uc033htw.3 
ENSMUST00000162278.8 Fhit ENSMUST00000162278.8 fragile histidine triad gene, transcript variant 2 (from RefSeq NM_010210.4) ENSMUST00000162278.1 ENSMUST00000162278.2 ENSMUST00000162278.3 ENSMUST00000162278.4 ENSMUST00000162278.5 ENSMUST00000162278.6 ENSMUST00000162278.7 FHIT_MOUSE NM_010210 O89106 Q6URW5 Q91VL1 uc007sfk.1 uc007sfk.2 uc007sfk.3 uc007sfk.4 This gene encodes a member of the HIT family of proteins that are characterized by the presence of a histidine triad sequence. The encoded protein is a diadenosine triphosphate hydrolase enzyme that cleaves the P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. This locus is very fragile and has been found to be altered in different types of cancers. Mice lacking the encoded protein display increased susceptibility to spontaneous and induced tumors. Ectopic expression of the encoded protein in such knockout mice inhibits tumor development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. Possesses dinucleoside triphosphate hydrolase activity (By similarity). Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (By similarity). Can also hydrolyze P(1)-P(4)-bis(5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP (By similarity). Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (By similarity). Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate (By similarity). Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate (By similarity). Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (By similarity). Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways (By similarity). Inhibits MDM2- mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis (By similarity). Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity). Functions as a tumor suppressor (PubMed:10758156, PubMed:11517343). Reaction=H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate = ADP + AMP + 2 H(+); Xref=Rhea:RHEA:13893, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58529, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=3.6.1.29; Evidence=; Reaction=adenosine 5'-phosphosulfate + H2O = AMP + 2 H(+) + sulfate; Xref=Rhea:RHEA:17041, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:58243, ChEBI:CHEBI:456215; EC=3.6.2.1; Evidence=; Reaction=adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'- phosphoramidate + 2 H(+) + sulfate; Xref=Rhea:RHEA:19197, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:28938, ChEBI:CHEBI:57890, ChEBI:CHEBI:58243; EC=2.7.7.51; Evidence=; Reaction=adenosine 5'-phosphoramidate + H2O = AMP + NH4(+); Xref=Rhea:RHEA:67916, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57890, ChEBI:CHEBI:456215; Evidence=; Homodimer. Interacts with UBE2I. Interacts with MDM2. Interacts with CTNNB1. Identified in a complex with CTNNB1 and LEF1 (By similarity). Cytoplasm Nucleus Mitochondrion Expressed in heart, brain, lung and skeletal muscle. Particularly strong expression in liver, testis and kidney, where it is confined to the tubular epithelium. Phosphorylation at Tyr-114 by SRC is required for induction of apoptosis. No visible phenotype at birth, but about 30% of the mice lacking one or both copies of Fhit died for unknown reasons at an age of about 19 months. This might be due to increased susceptibility to infections. Mice lacking one or both copies of Fhit show increased susceptibility to carcinogens. nucleotide binding fibrillar center catalytic activity nucleus cytoplasm cytosol plasma membrane purine nucleotide metabolic process DNA replication apoptotic process nucleotide metabolic process diadenosine triphosphate catabolic process nickel cation binding hydrolase activity ubiquitin protein ligase binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process identical protein binding bis(5'-adenosyl)-triphosphatase activity intrinsic apoptotic signaling pathway by p53 class mediator uc007sfk.1 uc007sfk.2 uc007sfk.3 uc007sfk.4 
ENSMUST00000162280.2 Lhfpl4 ENSMUST00000162280.2 lipoma HMGIC fusion partner-like protein 4 (from RefSeq NM_177763.3) ENSMUST00000162280.1 Garlh4 Kiaa4027 LHPL4_MOUSE Lh4 Lhfpl4 NM_177763 Q5DTS1 Q5U4E0 Q8BQU2 uc009dev.1 uc009dev.2 uc009dev.3 Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma- aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites (PubMed:28978485, PubMed:28279354, PubMed:29742426). Acts in concert with NLGN2 to recruit or stabilize GABAARs (PubMed:29742426). Interacts with GABA(A) receptor subunits (PubMed:28279354, PubMed:28978485, PubMed:29742426). Interacts with GABRB3 (PubMed:28978485). Interacts with GABRA2 (PubMed:28978485). Interacts with GABRG2 (PubMed:28978485, PubMed:29742426). Interacts with GABRA1 (PubMed:29742426). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Interacts with NLGN2; leading to mutual regulation of protein level and synaptic clustering (PubMed:29742426, PubMed:28978485). Cell projection, dendrite Postsynaptic cell membrane ; Multi-pass membrane protein Note=Specifically localizes to inhibitory postsynaptic sites (PubMed:28978485, PubMed:29742426). Colocalizes with GPHN, GABRG2 and NLGN2 at inhibitory postsynaptic sites (By similarity) (PubMed:29742426). Highly expressed in the brain, including the cortex, hippocampus, midbrain, olfactory bulb pona plus medulla (at protein level) (PubMed:26964900, PubMed:28279354, PubMed:29742426). Expressed in the in the cerebellar granular layer and in granular layer. Colocalized with GPHN at inhibitory synapses (PubMed:29742426). Weakly expressed in heart, testis, lung, intestine, vagina, ovary and uterus (PubMed:26964900). Contradictory results have been described and may be due to differences in the methods used for gene disruption (PubMed:28978485, PubMed:29742426). No visible phenotype, mice are viable and fertile until adulthood (PubMed:28978485). However cultured hippocampal neurons from deficient mice shown a dramatic decrease in both amplitude and frequency of miniature inhibitory postsynaptic currents (mIPSC) (PubMed:28978485). In contrast, deficient mice exhibit profound impairment of inhibitory synapse formation, prominent motor behavioral deficits and premature death (PubMed:29742426). Belongs to the LHFP family. Sequence=BAD90276.1; Type=Erroneous initiation; Evidence=; protein binding plasma membrane nervous system development membrane integral component of membrane cell junction dendrite cell projection synapse postsynaptic membrane GABA receptor binding inhibitory synapse gamma-aminobutyric acid receptor clustering regulation of inhibitory synapse assembly uc009dev.1 uc009dev.2 uc009dev.3 
ENSMUST00000162295.2 Clstn2 ENSMUST00000162295.2 calsyntenin 2, transcript variant 2 (from RefSeq NM_001413406.1) CSTN2_MOUSE Clstn2 Cs2 Cstn2 ENSMUST00000162295.1 Kiaa4134 NM_001413406 Q5DTM0 Q6P565 Q8C858 Q9ER65 uc009rde.1 uc009rde.2 uc009rde.3 Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory (PubMed:24613359, PubMed:26171716, PubMed:31529526). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Postsynaptic cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Golgi apparatus membrane ; Single-pass type I membrane protein Cell projection, dendrite Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ER65-1; Sequence=Displayed; Name=2; IsoId=Q9ER65-2; Sequence=VSP_032037; Restricted to the brain (PubMed:12498782). In the cerebral cortex, found in the somas and neuropil of all layers (PubMed:12498782). Expressed at highest levels in neurons of cortical layers 5 and 6 and, at lower levels, in neurons of the upper layers (PubMed:12498782). Highly expressed in Purkinje cells (PubMed:12498782). Also found in a few scattered interneurons throughout the granule cell layer and occasionally in neurons in the molecular layer (at protein level) (PubMed:12498782). Present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern) (PubMed:12498782). Binds synaptic Ca(2+) with its cytoplasmic domain. Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N- terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-gamma chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1. Mice show a deficit of GABAergic interneurons, associated with hyperactivity, deficient spatial memory and social behavior (PubMed:26171716, PubMed:28647593). Mice show a selective reduction in functional inhibitory synapses, associated with a selective reduction of parvalbumin interneurons in hippocampus and cortex (PubMed:26171716). In neurons, a reduction of symmetric (inhibitory) synaptic density, length of synaptic contacts and postsynaptic density is observed (PubMed:31529526). Moreover, cortical neurons are characterized by the predominance of the simplified type of synapses with the emergence of negative curvature of the synaptic zone (PubMed:31529526). Presynaptic zones of cortical neurons show an increased number of synaptic vesicles in opposite to the decreased number of synaptic vesicles in the presynaptic zones of hippocampal neurons (PubMed:31529526). Mice lacking Clstn1, Clstn2 and Clstn3 display behavior disorders, characterized by hyperactivity in normal environment, hypersensitivity to stress, and show tendency to freeze in novel environments (PubMed:35279170). Belongs to the calsyntenin family. Sequence=BAD90297.1; Type=Erroneous initiation; Evidence=; Golgi membrane calcium ion binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cell surface postsynaptic density membrane integral component of membrane postsynaptic membrane positive regulation of synaptic transmission positive regulation of synapse assembly glutamatergic synapse integral component of postsynaptic density membrane uc009rde.1 uc009rde.2 uc009rde.3 
ENSMUST00000162300.8 Grip2 ENSMUST00000162300.8 glutamate receptor interacting protein 2, transcript variant 4 (from RefSeq NR_177446.1) ENSMUST00000162300.1 ENSMUST00000162300.2 ENSMUST00000162300.3 ENSMUST00000162300.4 ENSMUST00000162300.5 ENSMUST00000162300.6 ENSMUST00000162300.7 G3XA20 G3XA20_MOUSE Grip2 NR_177446 uc012epd.1 uc012epd.2 uc012epd.3 uc012epd.4 uc012epd.5 cytoplasm plasma membrane Notch signaling pathway protein C-terminus binding positive regulation of neuron maturation postsynaptic density artery smooth muscle contraction protein transport membrane receptor signaling complex scaffold activity dendrite glutamate receptor binding dendritic shaft neuron spine postsynaptic membrane positive regulation of blood pressure neurotransmitter receptor transport, endosome to postsynaptic membrane glutamatergic synapse vesicle-mediated transport in synapse positive regulation of AMPA glutamate receptor clustering positive regulation of excitatory postsynaptic potential uc012epd.1 uc012epd.2 uc012epd.3 uc012epd.4 uc012epd.5 
ENSMUST00000162301.8 Cul2 ENSMUST00000162301.8 cullin 2, transcript variant 2 (from RefSeq NM_029402.3) CUL2_MOUSE Cul2 ENSMUST00000162301.1 ENSMUST00000162301.2 ENSMUST00000162301.3 ENSMUST00000162301.4 ENSMUST00000162301.5 ENSMUST00000162301.6 ENSMUST00000162301.7 NM_029402 Q3TUR8 Q9D4H8 uc008dya.1 uc008dya.2 uc008dya.3 uc008dya.4 Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (PubMed:33590678). Protein modification; protein ubiquitination. Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and a variable substrate-specific adapter. Component of the ECS(VHL) or CBC(VHL) complex containing VHL. Component of the ECS(MED8) complex with the probable substrate recognition component MED8. Component of multiple ECS complexes part of the DesCEND (destruction via C-end degrons) pathway, which contain either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component (By similarity). Component of the ECS(LRR1) complex with the substrate recognition component LRR1 (PubMed:33590678). Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, ELOB, ELOC and FEM1B. Part of an E3 ubiquitin-protein ligase complex including ZYG11B, CUL2 and Elongin BC. Part of an E3 ubiquitin-protein ligase complex including ZER1, CUL2 and Elongin BC. Interacts with RBX1, RNF7, FEM1B and TIP120A/CAND1. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2. Interacts (when neddylated) with ARIH1; leading to activate the E3 ligase activity of ARIH1. Interacts (unneddylated form) with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5; these interactions promote the cullin neddylation. Component of VCB (elongins BC/CUL2/VHL) complex that contains at least DCUN1D1, CUL2 and VHL; this complex triggers CUL2 neddylation and consequently cullin ring ligase (CRL) substrates polyubiquitylation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D4H8-1; Sequence=Displayed; Name=2; IsoId=Q9D4H8-2; Sequence=VSP_008823; Neddylated; which enhances the ubiquitination activity of ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes. CBC(VHL) complex formation seems to promote neddylation (By similarity). Deneddylated via its interaction with the COP9 signalosome (CSN) complex. Belongs to the cullin family. protein binding nucleoplasm nucleolus ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex protein catabolic process VCB complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process cullin-RING ubiquitin ligase complex Cul2-RING ubiquitin ligase complex ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process macromolecular complex binding uc008dya.1 uc008dya.2 uc008dya.3 uc008dya.4 
ENSMUST00000162306.2 Gm16262 ENSMUST00000162306.2 Gm16262 (from geneSymbol) BC044872 ENSMUST00000162306.1 uc292jrq.1 uc292jrq.2 uc292jrq.1 uc292jrq.2 
ENSMUST00000162315.8 AY512915 ENSMUST00000162315.8 AY512915 (from geneSymbol) ENSMUST00000162315.1 ENSMUST00000162315.2 ENSMUST00000162315.3 ENSMUST00000162315.4 ENSMUST00000162315.5 ENSMUST00000162315.6 ENSMUST00000162315.7 uc291hhk.1 uc291hhk.2 uc291hhk.1 uc291hhk.2 
ENSMUST00000162318.2 D030046N08Rik ENSMUST00000162318.2 D030046N08Rik (from geneSymbol) AK141732 ENSMUST00000162318.1 uc289pvn.1 uc289pvn.2 uc289pvn.1 uc289pvn.2 
ENSMUST00000162325.2 1810008B01Rik ENSMUST00000162325.2 1810008B01Rik (from geneSymbol) AK007368 ENSMUST00000162325.1 uc292eag.1 uc292eag.2 uc292eag.1 uc292eag.2 
ENSMUST00000162334.3 4930524O07Rik ENSMUST00000162334.3 4930524O07Rik (from geneSymbol) AK006616 ENSMUST00000162334.1 ENSMUST00000162334.2 uc292ksd.1 uc292ksd.2 uc292ksd.3 uc292ksd.1 uc292ksd.2 uc292ksd.3 
ENSMUST00000162342.8 Ap1s3 ENSMUST00000162342.8 adaptor-related protein complex AP-1, sigma 3 (from RefSeq NM_183027.2) AP1S3_MOUSE ENSMUST00000162342.1 ENSMUST00000162342.2 ENSMUST00000162342.3 ENSMUST00000162342.4 ENSMUST00000162342.5 ENSMUST00000162342.6 ENSMUST00000162342.7 NM_183027 Q7TN05 uc011wnw.1 uc011wnw.2 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity). Involved in TLR3 trafficking (By similarity). Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Golgi apparatus. Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane, clathrin-coated pit Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Belongs to the adaptor complexes small subunit family. molecular_function Golgi apparatus clathrin-coated pit protein targeting intracellular protein transport protein transport membrane vesicle-mediated transport membrane coat cytoplasmic vesicle membrane cytoplasmic vesicle intracellular membrane-bounded organelle uc011wnw.1 uc011wnw.2 
ENSMUST00000162347.2 Gm16028 ENSMUST00000162347.2 Gm16028 (from geneSymbol) ENSMUST00000162347.1 uc287jwm.1 uc287jwm.2 uc287jwm.1 uc287jwm.2 
ENSMUST00000162348.2 Gm16552 ENSMUST00000162348.2 Gm16552 (from geneSymbol) ENSMUST00000162348.1 uc290zgx.1 uc290zgx.2 uc290zgx.1 uc290zgx.2 
ENSMUST00000162349.8 Apbb2 ENSMUST00000162349.8 amyloid beta precursor protein binding family B member 2, transcript variant 1 (from RefSeq NM_009686.3) APBB2_MOUSE Apbb2 ENSMUST00000162349.1 ENSMUST00000162349.2 ENSMUST00000162349.3 ENSMUST00000162349.4 ENSMUST00000162349.5 ENSMUST00000162349.6 ENSMUST00000162349.7 Fe65l Fe65l1 NM_009686 Q6DFX8 Q9DBR4 uc033ijy.1 uc033ijy.2 uc033ijy.3 uc033ijy.4 Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (PubMed:25757569, PubMed:27734846). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (PubMed:27734846). Activates transcription of APP (By similarity). Interacts (via C-terminus) with APP (via C-terminus) (PubMed:18650440). Interacts with APLP2 (via cytoplasmic domain) (By similarity). Endoplasmic reticulum Golgi apparatus Early endosome Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DBR4-1; Sequence=Displayed; Name=2; IsoId=Q9DBR4-2; Sequence=VSP_011661; Name=3; IsoId=Q9DBR4-3; Sequence=VSP_011661, VSP_011662; Expressed in the brain, retinal lens and muscle cells (at protein level). Knockout mice develop cataracts from 16 months of age with defects such as ulcer-like anomalies in the cornea, and opacity in the lens cortex or wider lens. Decreased muscle strength, however clasping ability is unaffected (PubMed:25757569). Impaired spatial memory retrieval and learning (PubMed:27734846). Reduced branching of hippocampal neurites and increased fragmentation of neuromuscular junctions (PubMed:27734846). APBB1 and APBB2 double knockout mice show progressive retinal lens disruption from 1 month of age, morphologically lenses show massive vacuolization, lens capsule rupture and disruption of the lens fiber cells organization. Decreased muscle strength, however clasping ability is unaffected (PubMed:25757569, PubMed:27734846). Defects in peripheral motor function including balance and coordination, reduced environmental anxiety, reduced hippocampal basal synaptic transmission and synaptic plasticity (PubMed:27734846). beta-amyloid binding neuron migration protein binding nucleus cytoplasm regulation of transcription, DNA-templated cell cycle arrest axon guidance transcription factor binding actin filament-based movement extracellular matrix organization negative regulation of cell growth histone acetyltransferase binding positive regulation of apoptotic process negative regulation of apoptotic process protein stabilization uc033ijy.1 uc033ijy.2 uc033ijy.3 uc033ijy.4 
ENSMUST00000162350.3 C6 ENSMUST00000162350.3 Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. (from UniProt E9Q6D8) BC011251 C6 E9Q6D8 E9Q6D8_MOUSE ENSMUST00000162350.1 ENSMUST00000162350.2 uc288wss.1 uc288wss.2 Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9. Secreted Belongs to the complement C6/C7/C8/C9 family. Lacks conserved residue(s) required for the propagation of feature annotation. in utero embryonic development membrane attack complex extracellular space immune response complement activation positive regulation of apoptotic process uc288wss.1 uc288wss.2 
ENSMUST00000162359.8 Hipk2 ENSMUST00000162359.8 homeodomain interacting protein kinase 2, transcript variant 3 (from RefSeq NM_001294143.1) ENSMUST00000162359.1 ENSMUST00000162359.2 ENSMUST00000162359.3 ENSMUST00000162359.4 ENSMUST00000162359.5 ENSMUST00000162359.6 ENSMUST00000162359.7 HIPK2_MOUSE NM_001294143 Nbak1 O88905 Q99P45 Q99P46 Q9D2E6 Q9D474 Q9EQL2 Q9QZR4 Q9QZR5 Stank uc009bkz.1 uc009bkz.2 uc009bkz.3 uc009bkz.4 Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (By similarity). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Interacts with CREB1, SIAH1, WSB1, CBX4, TRADD, p53/TP53, TP73, TP63, CREBBP, DAXX, P53DINP1, SKI, SMAD1, SMAD2 and SMAD3, but not SMAD4. Interacts with SP100; positively regulates TP53-dependent transcription (By similarity). Interacts with ATF1, PML, RUNX1, EP300, NKX1-2, NKX2-5, UBE2I, HMGA1, CTBP1, AXIN1, NLK, MYB, POU4F1, POU4F2, POU4F3, UBE2I, UBL1 and ZBTB4. Probably part of a complex consisting of p53/TP53, HIPK2 and AXIN1. Interacts with DAZAP2; the interaction results in phosphorylation of DAZAP2 which causes localization of DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent degradation of HIPK2 (By similarity). Interacts with SIAH1; the interaction is promoted by DAZAP2 and results in SIAH1-mediated ubiquitination and subsequent proteasomal degradation of HIPK2 (By similarity). [Isoform 2]: Interacts with SPN/CD43 cytoplasmic tail. Q9QZR5; Q8CFN5: Mef2c; NbExp=5; IntAct=EBI-366905, EBI-643797; Q9QZR5; P06876: Myb; NbExp=2; IntAct=EBI-366905, EBI-366934; Q9QZR5; O54949: Nlk; NbExp=2; IntAct=EBI-366905, EBI-366894; Q9QZR5; P51608: MECP2; Xeno; NbExp=3; IntAct=EBI-366905, EBI-1189067; Q9QZR5; Q9Y6I7: WSB1; Xeno; NbExp=5; IntAct=EBI-366905, EBI-1171494; Nucleus, PML body toplasm [Isoform 2]: Nucleus Cytoplasm Note=Isoform 2 seems to be both nuclear and cytoplasmic. Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Nbak1b, b; IsoId=Q9QZR5-1; Sequence=Displayed; Name=2; Synonyms=Nbak1a, a; IsoId=Q9QZR5-2; Sequence=VSP_004808; Name=3; IsoId=Q9QZR5-3; Sequence=VSP_013135, VSP_013137; Name=4; IsoId=Q9QZR5-4; Sequence=VSP_013135, VSP_004808; Name=5; IsoId=Q9QZR5-5; Sequence=VSP_013136, VSP_013138, VSP_013139; Ubiquitous. Abundant in muscle, heart, small intestine, stomach, kidney and brain; and low in testis, skin and lung. At 15 dpc-17 dpc, mainly in the developing retina, telencephalon and myoblasts. At 12.5 dpc, detected in the developing trigeminal and dorsal root ganglia, and in the developing spinal cord (at protein level). Highly induced during primary fetal liver erythropoiesis. Expressed in the inner retina during late embryogenesis, in nucleus. Highest levels at 14.5 dpc for isoform 2 and P12.5 for isoform 1. During T-cell activation. Sumoylated. When conjugated it is directed to nuclear speckles. Desumoylated by SENP1. Sumoylation on Lys-32 is promoted by the E3 SUMO-protein ligase CBX4 (By similarity). Autophosphorylation at Tyr-361 in the activation loop activates the kinase and promotes nuclear localization. Ubiquitinated by FBXO3, WSB1 and SIAH1, leading to rapid proteasome-dependent degradation. The degradation mediated by FBXO3, but not ubiquitination, is prevented in the presence of PML. The degradation mediated by WSB1 and SIAH1 is reversibly reduced upon DNA damage. Cleaved at Asp-923 and Asp-984 by CASP6 in a p53/TP53-dependent manner. The cleaved form lacks the autoinhibitory C-terminal domain (AID), resulting in a hyperactive kinase, which potentiates p53/TP53 Ser-46 phosphorylation and subsequent activation of the cell death machinery. Inhibited terminal erythroid cell proliferation and terminal enucleation, as well as reduced accumulation of hemoglobin. Impaired transcription of many genes involved in cell proliferation and apoptosis, and of erythroid-specific genes involved in hemoglobin biosynthesis, such as HBA and SLC25A37/MFRN. Enhanced stability of CTNNB1; accumulation of beta-catenin leading to the potentiation of beta-catenin-mediated cell proliferation and tumor formation. Small eyes with deficient lens, abnormal retinal lamination, and thickened retinas. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. Sequence=AAC63011.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleotide binding RNA polymerase II activating transcription factor binding positive regulation of protein phosphorylation transcription corepressor activity protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity protein binding ATP binding nucleus cytoplasm protein phosphorylation apoptotic process cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator transforming growth factor beta receptor signaling pathway smoothened signaling pathway adult walking behavior positive regulation of cell proliferation adult locomotory behavior anterior/posterior pattern specification retina layer formation kinase activity phosphorylation nuclear body PML body transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation neuron differentiation positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway positive regulation of protein binding intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of DNA binding negative regulation of neuron apoptotic process positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade SMAD binding virion binding embryonic camera-type eye morphogenesis voluntary musculoskeletal movement positive regulation of sequence-specific DNA binding transcription factor activity embryonic retina morphogenesis in camera-type eye lens induction in camera-type eye SMAD protein signal transduction iris morphogenesis RNA polymerase II transcription factor complex negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process transcription coactivator activity DNA binding uc009bkz.1 uc009bkz.2 uc009bkz.3 uc009bkz.4 
ENSMUST00000162364.8 Mob4 ENSMUST00000162364.8 MOB family member 4, phocein, transcript variant 1 (from RefSeq NM_025283.3) ENSMUST00000162364.1 ENSMUST00000162364.2 ENSMUST00000162364.3 ENSMUST00000162364.4 ENSMUST00000162364.5 ENSMUST00000162364.6 ENSMUST00000162364.7 Mob3 Mobkl3 NM_025283 PHOCN_MOUSE Phocn Prei3 Q3TS21 Q6PEB6 Q8BSA3 Q9CX28 uc007bad.1 uc007bad.2 uc007bad.3 May play a role in membrane trafficking, specifically in membrane budding reactions. Binds STRN4 (By similarity). Interacts with DNM1 and EPS15 (By similarity). Interacts with nucleoside diphosphate kinase (By similarity). Binds STRN and STRN3. Part of a ternary complex containing MOB4/PHOCN, STRN and/or STRN3 and PPA2. Interacts with CTTNBP2 and CTTNBP2NL (By similarity). Cytoplasm, perinuclear region Membrane ; Peripheral membrane protein Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein Note=In a perinuclear punctate pattern. Associated with membranes and the Golgi stacks. Phosphorylated on serine residues. Belongs to the MOB1/phocein family. cytoplasm Golgi apparatus cytosol membrane kinase binding Golgi cisterna membrane neuronal cell body dendritic spine metal ion binding perinuclear region of cytoplasm uc007bad.1 uc007bad.2 uc007bad.3 
ENSMUST00000162372.8 Slc30a9 ENSMUST00000162372.8 solute carrier family 30 (zinc transporter), member 9, transcript variant 1 (from RefSeq NM_178651.4) ENSMUST00000162372.1 ENSMUST00000162372.2 ENSMUST00000162372.3 ENSMUST00000162372.4 ENSMUST00000162372.5 ENSMUST00000162372.6 ENSMUST00000162372.7 NM_178651 Q5IRJ6 Q66L46 Q7TNE9 Q8BGX8 Q8BUR1 Q8BZP2 Q8K2E0 Q8K376 Q8R0P1 Q9JK46 ZNT9_MOUSE uc008xpt.1 uc008xpt.2 uc008xpt.3 uc008xpt.4 Acts as a zinc transporter involved in intracellular zinc homeostasis (By similarity). Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes (PubMed:15988012). Plays a role in transcriptional activation of Wnt- responsive genes (PubMed:17344318). Mitochondrial proton-coupled zinc ion antiporter mediating the export of zinc from the mitochondria and involved in zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health (By similarity). In nucleus, functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes (PubMed:15988012, PubMed:17344318). Reaction=2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out); Xref=Rhea:RHEA:72627, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105; Evidence=; Interacts with GRIP1, ESR1, AR and CTNNB1. Mitochondrion membrane ; Multi-pass membrane protein Nucleus Endoplasmic reticulum Note=Partial co- localization with endoplasmic reticulum. Linked to mitochondrial ribosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5IRJ6-1; Sequence=Displayed; Name=2; IsoId=Q5IRJ6-2; Sequence=VSP_027088; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. chromatin binding nucleus cytoplasm endoplasmic reticulum cytoskeleton ion transport cation transport zinc II ion transport cellular zinc ion homeostasis cation transmembrane transporter activity membrane integral component of membrane ligand-dependent nuclear receptor binding ligand-dependent nuclear receptor transcription coactivator activity cytoplasmic vesicle positive regulation of transcription from RNA polymerase II promoter transmembrane transport cation transmembrane transport uc008xpt.1 uc008xpt.2 uc008xpt.3 uc008xpt.4 
ENSMUST00000162374.4 Gm28374 ENSMUST00000162374.4 Gm28374 (from geneSymbol) BC002119 ENSMUST00000162374.1 ENSMUST00000162374.2 ENSMUST00000162374.3 F6SG70 F6SG70_MOUSE Gm28374 uc289qjw.1 uc289qjw.2 uc289qjw.3 uc289qjw.1 uc289qjw.2 uc289qjw.3 
ENSMUST00000162387.6 Speer4a3 ENSMUST00000162387.6 spermatogenesis associated glutamate (E)-rich protein 4A3 (from RefSeq NM_001281516.1) ENSMUST00000162387.1 ENSMUST00000162387.2 ENSMUST00000162387.3 ENSMUST00000162387.4 ENSMUST00000162387.5 G3UY31 G3UY31_MOUSE Gm21671 NM_001281516 uc033ihz.1 uc033ihz.2 uc033ihz.3 uc033ihz.1 uc033ihz.2 uc033ihz.3 
ENSMUST00000162407.3 Gm16538 ENSMUST00000162407.3 Gm16538 (from geneSymbol) ENSMUST00000162407.1 ENSMUST00000162407.2 uc289qhs.1 uc289qhs.2 uc289qhs.3 uc289qhs.1 uc289qhs.2 uc289qhs.3 
ENSMUST00000162409.8 Fnbp1l ENSMUST00000162409.8 formin binding protein 1-like, transcript variant 2 (from RefSeq NM_153118.3) E9PUK3 E9PUK3_MOUSE ENSMUST00000162409.1 ENSMUST00000162409.2 ENSMUST00000162409.3 ENSMUST00000162409.4 ENSMUST00000162409.5 ENSMUST00000162409.6 ENSMUST00000162409.7 Fnbp1l NM_153118 uc008rer.1 uc008rer.2 uc008rer.3 uc008rer.4 uc008rer.5 Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cell cortex Cytoplasm, cytoskeleton Cytoplasmic vesicle Vesicle Belongs to the FNBP1 family. endocytosis uc008rer.1 uc008rer.2 uc008rer.3 uc008rer.4 uc008rer.5 
ENSMUST00000162415.9 Eif4g2 ENSMUST00000162415.9 eukaryotic translation initiation factor 4, gamma 2, transcript variant 1 (from RefSeq NM_013507.3) ENSMUST00000162415.1 ENSMUST00000162415.2 ENSMUST00000162415.3 ENSMUST00000162415.4 ENSMUST00000162415.5 ENSMUST00000162415.6 ENSMUST00000162415.7 ENSMUST00000162415.8 Eif4g2 G3XA17 G3XA17_MOUSE NM_013507 uc009jfy.1 uc009jfy.2 uc009jfy.3 Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. Belongs to the eukaryotic initiation factor 4G family. RNA binding translation initiation factor activity cytosol translational initiation heart development axon positive regulation of translation positive regulation of axon extension positive regulation of dendritic spine development uc009jfy.1 uc009jfy.2 uc009jfy.3 
ENSMUST00000162431.2 Prr35 ENSMUST00000162431.2 proline rich 35 (from RefSeq NM_001358019.1) A930017K11Rik E0CXQ2 E0CXQ2_MOUSE ENSMUST00000162431.1 NM_001358019 Prr35 uc008bcv.1 uc008bcv.2 uc008bcv.3 molecular_function cellular_component biological_process uc008bcv.1 uc008bcv.2 uc008bcv.3 
ENSMUST00000162432.2 Gm16169 ENSMUST00000162432.2 Gm16169 (from geneSymbol) AK137341 ENSMUST00000162432.1 uc008aki.1 uc008aki.2 uc008aki.1 uc008aki.2 
ENSMUST00000162443.8 C1s1 ENSMUST00000162443.8 complement component 1, s subcomponent 1, transcript variant 2 (from RefSeq NM_001097617.1) C1s1 E9Q6C2 E9Q6C2_MOUSE ENSMUST00000162443.1 ENSMUST00000162443.2 ENSMUST00000162443.3 ENSMUST00000162443.4 ENSMUST00000162443.5 ENSMUST00000162443.6 ENSMUST00000162443.7 NM_001097617 uc009drc.1 uc009drc.2 uc009drc.3 The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase activity calcium ion binding proteolysis complement activation, classical pathway peptidase activity hydrolase activity uc009drc.1 uc009drc.2 uc009drc.3 
ENSMUST00000162450.4 Etohd2 ENSMUST00000162450.4 Etohd2 (from geneSymbol) AK035969 ENSMUST00000162450.1 ENSMUST00000162450.2 ENSMUST00000162450.3 uc007qve.1 uc007qve.2 uc007qve.3 uc007qve.4 uc007qve.1 uc007qve.2 uc007qve.3 uc007qve.4 
ENSMUST00000162454.3 Gm15872 ENSMUST00000162454.3 Gm15872 (from geneSymbol) ENSMUST00000162454.1 ENSMUST00000162454.2 uc287pcv.1 uc287pcv.2 uc287pcv.1 uc287pcv.2 
ENSMUST00000162457.3 Gm15716 ENSMUST00000162457.3 Gm15716 (from geneSymbol) ENSMUST00000162457.1 ENSMUST00000162457.2 uc292ajm.1 uc292ajm.2 uc292ajm.1 uc292ajm.2 
ENSMUST00000162458.3 Gm16280 ENSMUST00000162458.3 Gm16280 (from geneSymbol) ENSMUST00000162458.1 ENSMUST00000162458.2 uc287tvh.1 uc287tvh.2 uc287tvh.3 uc287tvh.1 uc287tvh.2 uc287tvh.3 
ENSMUST00000162503.8 Adck5 ENSMUST00000162503.8 aarF domain containing kinase 5, transcript variant 1 (from RefSeq NM_172960.3) Adck5 E9PUK2 E9PUK2_MOUSE ENSMUST00000162503.1 ENSMUST00000162503.2 ENSMUST00000162503.3 ENSMUST00000162503.4 ENSMUST00000162503.5 ENSMUST00000162503.6 ENSMUST00000162503.7 NM_172960 uc011zuw.1 uc011zuw.2 uc011zuw.3 uc011zuw.4 Belongs to the protein kinase superfamily. ADCK protein kinase family. membrane integral component of membrane uc011zuw.1 uc011zuw.2 uc011zuw.3 uc011zuw.4 
ENSMUST00000162505.8 Tbp ENSMUST00000162505.8 TATA box binding protein (from RefSeq NM_013684.3) ENSMUST00000162505.1 ENSMUST00000162505.2 ENSMUST00000162505.3 ENSMUST00000162505.4 ENSMUST00000162505.5 ENSMUST00000162505.6 ENSMUST00000162505.7 NM_013684 Q6RI65 Q6RI65_MOUSE Tbp uc008aoo.1 uc008aoo.2 uc008aoo.3 uc008aoo.4 Nucleus Belongs to the TBP family. nuclear chromatin core promoter proximal region sequence-specific DNA binding transcription factor activity, core RNA polymerase III binding core promoter binding TFIIB-class transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor TFIID complex transcription factor TFIIA complex nuclear euchromatin DNA-templated transcription, initiation transcription from RNA polymerase II promoter transcription from RNA polymerase III promoter spermatogenesis transcription factor binding obsolete general RNA polymerase II transcription factor activity aryl hydrocarbon receptor binding enzyme binding macromolecular complex transcription regulatory region DNA binding positive regulation of transcription, DNA-templated RNA polymerase II transcriptional preinitiation complex assembly repressing transcription factor binding transcriptional preinitiation complex uc008aoo.1 uc008aoo.2 uc008aoo.3 uc008aoo.4 
ENSMUST00000162508.9 Glipr1 ENSMUST00000162508.9 Membrane ; Single-pass membrane protein (from UniProt Q9CWG1) BC098231 ENSMUST00000162508.1 ENSMUST00000162508.2 ENSMUST00000162508.3 ENSMUST00000162508.4 ENSMUST00000162508.5 ENSMUST00000162508.6 ENSMUST00000162508.7 ENSMUST00000162508.8 GLIP1_MOUSE Q9CWG1 uc287uwb.1 uc287uwb.2 Membrane ; Single-pass membrane protein Belongs to the CRISP family. extracellular region extracellular space membrane integral component of membrane uc287uwb.1 uc287uwb.2 
ENSMUST00000162512.8 Gtpbp8 ENSMUST00000162512.8 GTP-binding protein 8 (putative), transcript variant 1 (from RefSeq NM_025332.3) ENSMUST00000162512.1 ENSMUST00000162512.2 ENSMUST00000162512.3 ENSMUST00000162512.4 ENSMUST00000162512.5 ENSMUST00000162512.6 ENSMUST00000162512.7 GTPB8_MOUSE NM_025332 Q3KNM0 Q9CY28 uc007zhq.1 uc007zhq.2 uc007zhq.3 uc007zhq.4 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CY28-1; Sequence=Displayed; Name=2; IsoId=Q9CY28-2; Sequence=VSP_034058; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. nucleotide binding GTP binding mitochondrion biological_process metal ion binding uc007zhq.1 uc007zhq.2 uc007zhq.3 uc007zhq.4 
ENSMUST00000162514.3 Cyp2j7 ENSMUST00000162514.3 cytochrome P450, family 2, subfamily j, polypeptide 7 (from RefSeq NM_001425033.1) A0A140T8U1 A0A140T8U1_MOUSE Cyp2j7 ENSMUST00000162514.1 ENSMUST00000162514.2 NM_001425033 uc290nwv.1 uc290nwv.2 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc290nwv.1 uc290nwv.2 
ENSMUST00000162520.3 Gm16136 ENSMUST00000162520.3 Gm16136 (from geneSymbol) ENSMUST00000162520.1 ENSMUST00000162520.2 uc288xqm.1 uc288xqm.2 uc288xqm.3 uc288xqm.1 uc288xqm.2 uc288xqm.3 
ENSMUST00000162538.9 Ciapin1 ENSMUST00000162538.9 cytokine induced apoptosis inhibitor 1 (from RefSeq NM_134141.4) CPIN1_MOUSE Ciapin1 ENSMUST00000162538.1 ENSMUST00000162538.2 ENSMUST00000162538.3 ENSMUST00000162538.4 ENSMUST00000162538.5 ENSMUST00000162538.6 ENSMUST00000162538.7 ENSMUST00000162538.8 NM_134141 Q3UJW5 Q8VC24 Q8WTY4 Q91W83 uc009mxa.1 uc009mxa.2 uc009mxa.3 uc009mxa.4 Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (PubMed:14970183). Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Monomer. Interacts with NDOR1. Interacts with CHCHD4. Q8WTY4; Q9CQM9: Glrx3; NbExp=4; IntAct=EBI-2943068, EBI-4319195; Cytoplasm Nucleus Mitochondrion intermembrane space Expressed from early embryogenesis. By cytokines such as IL3 and THPO. The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation. The N-terminal domain has structural similarity with S- adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters. Death in late gestation due to defective definitive hematopoiesis in the fetal liver, possibly due to initiated apoptosis in erythroid cells during terminal maturation. 'Ana-mors-in' means 'anti-death molecule' in Latin. Belongs to the anamorsin family. protein binding nucleus nucleoplasm nucleolus cytoplasm mitochondrion mitochondrial intermembrane space apoptotic process methyltransferase activity electron carrier activity iron-sulfur cluster assembly electron transport chain hemopoiesis methylation negative regulation of apoptotic process metal ion binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding 4 iron, 4 sulfur cluster binding uc009mxa.1 uc009mxa.2 uc009mxa.3 uc009mxa.4 
ENSMUST00000162545.2 Gm16564 ENSMUST00000162545.2 Gm16564 (from geneSymbol) BC025469 ENSMUST00000162545.1 uc287ohp.1 uc287ohp.2 uc287ohp.1 uc287ohp.2 
ENSMUST00000162554.8 Ift56 ENSMUST00000162554.8 intraflagellar transport 56 (from RefSeq NM_153600.2) ENSMUST00000162554.1 ENSMUST00000162554.2 ENSMUST00000162554.3 ENSMUST00000162554.4 ENSMUST00000162554.5 ENSMUST00000162554.6 ENSMUST00000162554.7 Hop IFT56_MOUSE Ift56 NM_153600 Q8BS45 Ttc26 uc009bkc.1 uc009bkc.2 uc009bkc.3 Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU (PubMed:22718903, PubMed:25340710). Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme (PubMed:28264835). Component of the IFT complex B. Interacts with IFT46; the interaction is direct. Cell projection, cilium Note=Localizes at the base to the ciliary transition zone. High expression detected in testis. Detected also retina, kidney, lung and brain tissue. The expression level is low in spleen (PubMed:22718903). Expressed in the developing liver (PubMed:31595528). Present in the airway epithelial cells and the testes (at protein level) (PubMed:25340710). Expressed during early development stages (12.5 dpc, 13.5 dpc, and 14.5 dpc). Partial embryonic lethality and patterning defects. Surviving mice show hopping gait, polydactyly, hydrocephalus, and male sterility. Impaired hedgehog signaling. Primary cilia are not reduced in number and their length is normal (PubMed:25340710). Mice exhibit defective cilia structure, including abnormal positioning and number of ciliary microtubule doublets, abnormal localization of IFT complex B components and significantly reduced ciliary tip accumulation of proteins GLI2 and GLI3 (PubMed:28264835). Belongs to the IFT56 family. protein binding centrosome cilium smoothened signaling pathway spermatid development photoreceptor cell morphogenesis protein transport intraciliary transport particle B axoneme assembly intraciliary anterograde transport intraciliary transport involved in cilium assembly ciliary basal body intraciliary transport cell projection photoreceptor cell differentiation cilium assembly protein localization to cilium ciliary base manchette assembly uc009bkc.1 uc009bkc.2 uc009bkc.3 
ENSMUST00000162564.7 Gm45062 ENSMUST00000162564.7 Gm45062 (from geneSymbol) AF374476 E0CZ38 E0CZ38_MOUSE ENSMUST00000162564.1 ENSMUST00000162564.2 ENSMUST00000162564.3 ENSMUST00000162564.4 ENSMUST00000162564.5 ENSMUST00000162564.6 Gm16039 Gm45062 uc291cmh.1 uc291cmh.2 uc291cmh.1 uc291cmh.2 
ENSMUST00000162577.2 Pitpnm2os2 ENSMUST00000162577.2 phosphatidylinositol transfer protein, membrane-associated 2, opposite strand 2, transcript variant 2 (from RefSeq NR_165288.1) ENSMUST00000162577.1 NR_165288 uc290ztx.1 uc290ztx.2 uc290ztx.1 uc290ztx.2 
ENSMUST00000162592.8 Zfp27 ENSMUST00000162592.8 zinc finger protein 27, transcript variant 7 (from RefSeq NM_001421815.1) ENSMUST00000162592.1 ENSMUST00000162592.2 ENSMUST00000162592.3 ENSMUST00000162592.4 ENSMUST00000162592.5 ENSMUST00000162592.6 ENSMUST00000162592.7 Mkr4 NM_001421815 P10077 Q6PCZ6 Q8CED4 ZFP27_MOUSE Zfp-27 uc033iyc.1 uc033iyc.2 uc033iyc.3 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P10077-1; Sequence=Displayed; Name=2; IsoId=P10077-2; Sequence=VSP_016025; Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=CAA31106.1; Type=Frameshift; Evidence=; nucleic acid binding nucleus regulation of transcription, DNA-templated metal ion binding uc033iyc.1 uc033iyc.2 uc033iyc.3 
ENSMUST00000162594.8 Bud31 ENSMUST00000162594.8 BUD31 homolog, transcript variant 2 (from RefSeq NM_001310771.1) BUD31_MOUSE E0CX20 ENSMUST00000162594.1 ENSMUST00000162594.2 ENSMUST00000162594.3 ENSMUST00000162594.4 ENSMUST00000162594.5 ENSMUST00000162594.6 ENSMUST00000162594.7 NM_001310771 Q6PGH1 uc057bwa.1 uc057bwa.2 uc057bwa.3 Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. Identified in the spliceosome C complex. May interact with AR. Nucleus Note=Detected in chromatin at the promoter of AR target genes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PGH1-1; Sequence=Displayed; Name=2; IsoId=Q6PGH1-2; Sequence=VSP_059351; Contains a short sequence motif (Phe-Xaa-Xaa-Phe-Tyr) that can bind to AR and may modulate AR activity. Belongs to the BUD31 (G10) family. mRNA splicing, via spliceosome nuclear chromatin molecular_function cellular_component nucleus spliceosomal complex mRNA processing biological_process RNA splicing ligand-dependent nuclear receptor transcription coactivator activity nuclear hormone receptor binding U2-type catalytic step 2 spliceosome positive regulation of nucleic acid-templated transcription positive regulation of androgen receptor activity uc057bwa.1 uc057bwa.2 uc057bwa.3 
ENSMUST00000162610.8 Aig1 ENSMUST00000162610.8 androgen-induced 1, transcript variant 2 (from RefSeq NM_001347362.1) AIG1_MOUSE ENSMUST00000162610.1 ENSMUST00000162610.2 ENSMUST00000162610.3 ENSMUST00000162610.4 ENSMUST00000162610.5 ENSMUST00000162610.6 ENSMUST00000162610.7 NM_001347362 Q8CI90 Q9CW23 Q9D8B1 uc007elb.1 uc007elb.2 uc007elb.3 uc007elb.4 Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (By similarity). Shows a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (By similarity). Reaction=9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy- octadecanoate + H(+) + hexadecanoate; Xref=Rhea:RHEA:52052, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:83670, ChEBI:CHEBI:136286; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52053; Evidence=; Reaction=12-hexadecanoyloxy-octadecanoate + H2O = 12- hydroxyoctadecanoate + H(+) + hexadecanoate; Xref=Rhea:RHEA:52056, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:83677, ChEBI:CHEBI:84201; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52057; Evidence=; Reaction=9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 9-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52068, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:136286, ChEBI:CHEBI:136309; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52069; Evidence=; Reaction=12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 12-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:52072, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:84201, ChEBI:CHEBI:136312; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52073; Evidence=; Reaction=13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 13-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52076, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:136304, ChEBI:CHEBI:136315; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52077; Evidence=; Reaction=9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy- octadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52096, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:136286, ChEBI:CHEBI:136373; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52097; Evidence=; Reaction=12-octadecanoyloxy-octadecanoate + H2O = 12- hydroxyoctadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:84201, ChEBI:CHEBI:136330; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52081; Evidence=; Reaction=13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy- octadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52084, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:136304, ChEBI:CHEBI:136335; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52085; Evidence=; Reaction=9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)- octadecenoate + 9-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52048, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:136282, ChEBI:CHEBI:136286; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52049; Evidence=; Reaction=12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)- octadecenoate + 12-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:52060, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:84201, ChEBI:CHEBI:136302; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52061; Evidence=; Reaction=13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)- octadecenoate + 13-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:136303, ChEBI:CHEBI:136304; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52065; Evidence=; Reaction=5-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 5-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52092, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:136369, ChEBI:CHEBI:136370; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52093; Evidence=; Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D8B1-2; Sequence=Displayed; Name=2; IsoId=Q9D8B1-1; Sequence=VSP_060696; By dihydrotestosterone (DHT). Belongs to the AIG1 family. plasma membrane lipid metabolic process membrane integral component of membrane hydrolase activity long-chain fatty acid catabolic process uc007elb.1 uc007elb.2 uc007elb.3 uc007elb.4 
ENSMUST00000162616.8 Gm45711 ENSMUST00000162616.8 Membrane ; Multi- pass membrane protein (from UniProt E0CXA2) AK006679 Cmtm1 E0CXA2 E0CXA2_MOUSE ENSMUST00000162616.1 ENSMUST00000162616.2 ENSMUST00000162616.3 ENSMUST00000162616.4 ENSMUST00000162616.5 ENSMUST00000162616.6 ENSMUST00000162616.7 Gm45711 uc292cpm.1 uc292cpm.2 Membrane ; Multi- pass membrane protein molecular_function biological_process membrane integral component of membrane uc292cpm.1 uc292cpm.2 
ENSMUST00000162641.2 Gm16282 ENSMUST00000162641.2 Gm16282 (from geneSymbol) ENSMUST00000162641.1 uc291nol.1 uc291nol.2 uc291nol.1 uc291nol.2 
ENSMUST00000162649.3 Gm16251 ENSMUST00000162649.3 Gm16251 (from geneSymbol) ENSMUST00000162649.1 ENSMUST00000162649.2 uc291mnn.1 uc291mnn.2 uc291mnn.3 uc291mnn.1 uc291mnn.2 uc291mnn.3 
ENSMUST00000162650.8 Cd46 ENSMUST00000162650.8 CD46 antigen, complement regulatory protein, transcript variant 1 (from RefSeq NM_010778.4) ENSMUST00000162650.1 ENSMUST00000162650.2 ENSMUST00000162650.3 ENSMUST00000162650.4 ENSMUST00000162650.5 ENSMUST00000162650.6 ENSMUST00000162650.7 MCP_MOUSE Mcp NM_010778 O88174 Q9R0R9 uc057awd.1 uc057awd.2 uc057awd.3 May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN. [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa. [Isoform 2]: Secreted Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=O88174-1; Sequence=Displayed; Name=2; IsoId=O88174-2; Sequence=VSP_019038, VSP_019039; Present only in testis (at protein level). Not expressed until 29 dpc. Expressed in parallel with synthesis of spermatids. May be O-glycosylated. N-glycosylated. Mice have normal testis and fertile sperm. [Isoform 2]: Lacks transmembrane domain, probably secreted. acrosomal vesicle complement binding inner acrosomal membrane T cell mediated immunity extracellular region cytoplasm Golgi apparatus plasma membrane proteolysis single fertilization regulation of Notch signaling pathway cell surface positive regulation of gene expression negative regulation of gene expression membrane integral component of membrane basolateral plasma membrane cytoplasmic vesicle interleukin-10 production positive regulation of interleukin-10 production sequestering of extracellular ligand from receptor positive regulation of T cell proliferation negative regulation of catalytic activity positive regulation of memory T cell differentiation cadherin binding positive regulation of regulatory T cell differentiation negative regulation of complement activation positive regulation of transforming growth factor beta production endopeptidase activity enzyme inhibitor activity uc057awd.1 uc057awd.2 uc057awd.3 
ENSMUST00000162655.9 Cep63 ENSMUST00000162655.9 centrosomal protein 63, transcript variant 35 (from RefSeq NR_176410.1) CEP63_MOUSE Cep63 D9Mgc48e ENSMUST00000162655.1 ENSMUST00000162655.2 ENSMUST00000162655.3 ENSMUST00000162655.4 ENSMUST00000162655.5 ENSMUST00000162655.6 ENSMUST00000162655.7 ENSMUST00000162655.8 NR_176410 Q3UPP8 Q80ZM0 uc292kct.1 uc292kct.2 Required for normal spindle assembly (PubMed:24240477). Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity). Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (By similarity). Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response (By similarity). Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination (By similarity). Interacts with CEP152 and CDK1; these interactions recruit both ligands to centrosomes. Interacts with CDK2, CDK5RAP2, WDR62, CEP90, KIAA0753/moonraker and CCDC14. CEP63, CDK5RAP2, CEP152, WDR62 are proposed to form a stepwise assembled complex at the centrosome forming a ring near parental centrioles. Interacts with CCDC57; the interaction is required for their location to proximal end of centrioles. Interacts with FXR1; promoting its stabilization. Q3UPP8; A2AUM9: Cep152; NbExp=2; IntAct=EBI-16081652, EBI-2554268; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Note=Colocalizes with CDK5RAP2, CEP152 and WDR62in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UPP8-1; Sequence=Displayed; Name=2; IsoId=Q3UPP8-2; Sequence=VSP_037843, VSP_037845, VSP_037846; Name=3; IsoId=Q3UPP8-3; Sequence=VSP_037844; Polyubiquitinated via 'Lys-48'-linked ubiquitin, leading to its degradation. Deubiquitinated by USP36, promoting its stabilization. CEP63 and DEUP1 paralogs are both involved in centriole amplification: while CEP63 mediates mother-centriole-dependent centriole duplication, DEUP1 mediates de novo centriole amplification in multiciliated cells. Belongs to the CEP63 family. Sequence=AAH48718.1; Type=Frameshift; Evidence=; DNA damage checkpoint spindle pole protein binding cytoplasm centrosome centriole microtubule organizing center cytoskeleton cellular response to DNA damage stimulus cell cycle centriole replication reciprocal meiotic recombination signal transduction in response to DNA damage meiotic telomere clustering spindle assembly centrosome duplication cell division protein localization to centrosome de novo centriole assembly involved in multi-ciliated epithelial cell differentiation negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator uc292kct.1 uc292kct.2 
ENSMUST00000162659.2 Zfp677 ENSMUST00000162659.2 Nucleus (from UniProt Q6PEP4) AK043955 ENSMUST00000162659.1 Q6PEP4 Q6PEP4_MOUSE Zfp677 uc008aqt.1 uc008aqt.2 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc008aqt.1 uc008aqt.2 
ENSMUST00000162671.8 Fgd4 ENSMUST00000162671.8 FYVE, RhoGEF and PH domain containing 4, transcript variant 1 (from RefSeq NM_001301817.2) A1L355 ENSMUST00000162671.1 ENSMUST00000162671.2 ENSMUST00000162671.3 ENSMUST00000162671.4 ENSMUST00000162671.5 ENSMUST00000162671.6 ENSMUST00000162671.7 FGD4_MOUSE NM_001301817 Q3UEB6 Q8BW60 Q8BZI7 Q91ZT3 Q91ZT4 Q91ZT5 uc289cru.1 uc289cru.2 This gene is a member of the FYVE, RhoGEF and PH domain containing (FGD) family. The encoded protein is a Cdc42-specific guanine nucleotide exchange factor (GEF) that plays an essential role in regulating the actin cytoskeleton and cell morphology. Disruption of the gene in mouse causes abnormal nerve development and dysmyelination. Mutations in a similar gene in human can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates MAPK8 (By similarity). Plays a role in regulating the actin cytoskeleton and cell shape. Promotes the formation of lamellipodia. Homooligomer. Cytoplasm, cytoskeleton Cell projection, filopodium Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Frabin alpha; IsoId=Q91ZT5-1; Sequence=Displayed; Name=2; Synonyms=Frabin beta; IsoId=Q91ZT5-2; Sequence=VSP_013086, VSP_013087; Name=3; Synonyms=Frabin gamma; IsoId=Q91ZT5-3; Sequence=VSP_013084, VSP_013085; Name=4; IsoId=Q91ZT5-4; Sequence=VSP_013083, VSP_013084, VSP_013085; Detected in thymus, lung, heart, skeletal muscle, small intestine, liver, kidney, spleen and testis. Expressed in all parts of the brain and in the spinal cord at embryonic, postnatal, and adult stages. Levels of expression are lower in postnatal and adult tissues than in embryonic tissues. The part of the protein spanning the actin filament-binding domain together with the DH domain and the first PH domain is necessary and sufficient for microspike formation. Activation of MAPK8 requires the presence of all domains with the exception of the actin filament- binding domain (By similarity). actin binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cytoplasm cytoskeleton activation of JUN kinase activity regulation of cell shape lamellipodium lamellipodium assembly microspike assembly filopodium regulation of Rho protein signal transduction cell projection metal ion binding actin filament binding uc289cru.1 uc289cru.2 
ENSMUST00000162676.2 4930558K02Rik ENSMUST00000162676.2 RIKEN cDNA 4930558K02 gene, transcript variant 2 (from RefSeq NM_001204905.1) 4930558K02Rik E0CXC6 E0CXC6_MOUSE ENSMUST00000162676.1 NM_001204905 uc029qum.1 uc029qum.2 uc029qum.3 molecular_function cellular_component biological_process uc029qum.1 uc029qum.2 uc029qum.3 
ENSMUST00000162686.8 Tyw5 ENSMUST00000162686.8 tRNA-yW synthesizing protein 5, transcript variant 3 (from RefSeq NM_001302964.1) A2RSX7 ENSMUST00000162686.1 ENSMUST00000162686.2 ENSMUST00000162686.3 ENSMUST00000162686.4 ENSMUST00000162686.5 ENSMUST00000162686.6 ENSMUST00000162686.7 NM_001302964 Q3UT82 Q4KL17 TYW5_MOUSE uc007bba.1 uc007bba.2 uc007bba.3 uc007bba.4 tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a- amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes. Reaction=2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate; Xref=Rhea:RHEA:37899, Rhea:RHEA- COMP:10379, Rhea:RHEA-COMP:11848, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:73543, ChEBI:CHEBI:73603; EC=1.14.11.42; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37900; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. Homodimer. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2RSX7-1; Sequence=Displayed; Name=2; IsoId=A2RSX7-2; Sequence=VSP_029107, VSP_029108; Belongs to the TYW5 family. tRNA binding iron ion binding cellular_component tRNA processing oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors wybutosine biosynthetic process protein homodimerization activity metal ion binding dioxygenase activity oxidation-reduction process uc007bba.1 uc007bba.2 uc007bba.3 uc007bba.4 
ENSMUST00000162708.7 Unc93b1 ENSMUST00000162708.7 unc-93 homolog B1, TLR signaling regulator, transcript variant 1 (from RefSeq NM_019449.3) ENSMUST00000162708.1 ENSMUST00000162708.2 ENSMUST00000162708.3 ENSMUST00000162708.4 ENSMUST00000162708.5 ENSMUST00000162708.6 NM_019449 O89077 Q3TNR9 Q710D2 Q8CIK1 Q8R3D0 Q8VCW4 UN93B_MOUSE Unc93b Unc93b1 uc008fxs.1 uc008fxs.2 uc008fxs.3 Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. Interacts with TLR3, TLR5, TLR7, TLR8, TLR9 and TLR13 (probably via transmembrane domain). Q8VCW4; O96005: CLPTM1; Xeno; NbExp=2; IntAct=EBI-6116986, EBI-2873194; Q8VCW4; P51617: IRAK1; Xeno; NbExp=2; IntAct=EBI-6116986, EBI-358664; Q8VCW4; Q96N66: MBOAT7; Xeno; NbExp=2; IntAct=EBI-6116986, EBI-6116499; Q8VCW4; O15260: SURF4; Xeno; NbExp=2; IntAct=EBI-6116986, EBI-1044848; Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Colocalizes with LAMP5 in large endosomal intracellular vesicles (By similarity). Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VCW4-1; Sequence=Displayed; Name=2; IsoId=Q8VCW4-2; Sequence=VSP_014036; Upon interleukin-4 treatment in B-cells. N-glycosylated. Belongs to the unc-93 family. Sequence=AAH25587.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cell morphogenesis toll-like receptor signaling pathway adaptive immune response immune system process protein binding lysosome endosome endoplasmic reticulum endoplasmic reticulum membrane intracellular protein transport membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II cytoplasmic vesicle early phagosome toll-like receptor 3 signaling pathway toll-like receptor 7 signaling pathway toll-like receptor 9 signaling pathway Toll-like receptor binding innate immune response phagocytic vesicle defense response to virus positive regulation of interleukin-6 secretion positive regulation of interleukin-12 secretion uc008fxs.1 uc008fxs.2 uc008fxs.3 
ENSMUST00000162713.9 Dnal4 ENSMUST00000162713.9 Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity). (from UniProt Q9DCM4) AK132061 DNAL4_MOUSE Dnalc4 ENSMUST00000162713.1 ENSMUST00000162713.2 ENSMUST00000162713.3 ENSMUST00000162713.4 ENSMUST00000162713.5 ENSMUST00000162713.6 ENSMUST00000162713.7 ENSMUST00000162713.8 O54793 Q3V233 Q99K65 Q9DCM4 uc288zrv.1 uc288zrv.2 Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity). Consists of at least two heavy chains and a number of intermediate and light chains. Cytoplasm, cytoskeleton, cilium axoneme Belongs to the dynein light chain family. Sequence=AK002657; Type=Frameshift; Evidence=; motor activity cytoplasm cytoskeleton microtubule cilium microtubule-based process dynein complex cell projection dynein intermediate chain binding dynein light intermediate chain binding positive regulation of ATP-dependent microtubule motor activity, plus-end-directed ATP-dependent microtubule motor activity, plus-end-directed uc288zrv.1 uc288zrv.2 
ENSMUST00000162724.3 Gm16299 ENSMUST00000162724.3 Gm16299 (from geneSymbol) ENSMUST00000162724.1 ENSMUST00000162724.2 uc289sjv.1 uc289sjv.2 uc289sjv.3 uc289sjv.1 uc289sjv.2 uc289sjv.3 
ENSMUST00000162726.5 Znhit2 ENSMUST00000162726.5 zinc finger, HIT domain containing 2 (from RefSeq NM_013859.2) ENSMUST00000162726.1 ENSMUST00000162726.2 ENSMUST00000162726.3 ENSMUST00000162726.4 NM_013859 ORF6 Q8C356 Q8VCQ7 Q9QY66 ZNHI2_MOUSE uc008ggv.1 uc008ggv.2 uc008ggv.3 May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (By similarity). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (By similarity). May play a role in regulating the composition of the U5 snRNP complex (By similarity). Interacts (via HIT-type zinc finger) with RUVBL2 in the presence of ATP or ADP; shows a stronger interaction in the presence of ADP. Low expression in most tissues; highly expressed in testis; particularly in seminiferous tubules. metal ion binding uc008ggv.1 uc008ggv.2 uc008ggv.3 
ENSMUST00000162735.8 Tc2n ENSMUST00000162735.8 tandem C2 domains, nuclear, transcript variant 2 (from RefSeq NM_001082976.2) ENSMUST00000162735.1 ENSMUST00000162735.2 ENSMUST00000162735.3 ENSMUST00000162735.4 ENSMUST00000162735.5 ENSMUST00000162735.6 ENSMUST00000162735.7 Mtac2d1 NM_001082976 Q3UW74 Q91XT6 Q9D4A0 TAC2N_MOUSE uc007oto.1 uc007oto.2 uc007oto.3 uc007oto.4 Nucleus nucleus uc007oto.1 uc007oto.2 uc007oto.3 uc007oto.4 
ENSMUST00000162741.8 Gm9946 ENSMUST00000162741.8 predicted gene 9946 (from RefSeq NR_168036.1) ENSMUST00000162741.1 ENSMUST00000162741.2 ENSMUST00000162741.3 ENSMUST00000162741.4 ENSMUST00000162741.5 ENSMUST00000162741.6 ENSMUST00000162741.7 NR_168036 uc009dkw.1 uc009dkw.2 uc009dkw.1 uc009dkw.2 
ENSMUST00000162746.2 Selp ENSMUST00000162746.2 selectin, platelet (from RefSeq NM_011347.2) ENSMUST00000162746.1 Grmp LYAM3_MOUSE NM_011347 Q01102 Q32MF1 uc007dhz.1 uc007dhz.2 uc007dhz.3 Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Interacts with SNX17. Interacts with SELPLG/PSGL1 and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of SELPLG and PODXL2, and specific tyrosine sulfation on SELPLG. Cell membrane ; Single-pass type I membrane protein Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. By TNF-alpha. Induced expression in lung, liver, kidney and heart after endotoxin treatment. Belongs to the selectin/LECAM family. Name=Functional Glycomics Gateway - Glycan Binding; Note=P-selectin; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_284"; lipopolysaccharide binding positive regulation of leukocyte migration regulation of cellular extravasation calcium ion binding protein binding extracellular space plasma membrane integral component of plasma membrane inflammatory response cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion heparin binding external side of plasma membrane positive regulation of platelet activation positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules carbohydrate binding platelet alpha granule membrane regulation of integrin activation sialic acid binding calcium-mediated signaling using intracellular calcium source fucose binding positive regulation of cell adhesion metal ion binding calcium-dependent protein binding leukocyte migration leukocyte tethering or rolling oligosaccharide binding cellular response to interleukin-6 cell-cell adhesion uc007dhz.1 uc007dhz.2 uc007dhz.3 
ENSMUST00000162751.8 Stau2 ENSMUST00000162751.8 staufen double-stranded RNA binding protein 2, transcript variant 3 (from RefSeq NM_025303.3) ENSMUST00000162751.1 ENSMUST00000162751.2 ENSMUST00000162751.3 ENSMUST00000162751.4 ENSMUST00000162751.5 ENSMUST00000162751.6 ENSMUST00000162751.7 NM_025303 Q8BSY8 Q8CJ66 Q8CJ67 Q8R175 Q91Z19 Q9D5N7 STAU2_MOUSE uc007ajn.1 uc007ajn.2 uc007ajn.3 uc007ajn.4 RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). Interacts with microtubules. Isoform 2 and isoform 3 may also interact with ribosomes, and this association is independent of translation (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (By similarity). Cytoplasm Nucleus Nucleus, nucleolus Endoplasmic reticulum Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1- independent pathways. May also be found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted. Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Long; IsoId=Q8CJ67-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q8CJ67-2; Sequence=VSP_015379, VSP_015380; Name=3; IsoId=Q8CJ67-3; Sequence=VSP_015379, VSP_015380, VSP_015383, VSP_015384; Name=4; IsoId=Q8CJ67-4; Sequence=VSP_015378, VSP_015383, VSP_015384; Name=5; IsoId=Q8CJ67-5; Sequence=VSP_015381, VSP_015382; Expressed in brain and neurons, where isoform 2 and isoform 3 appear to be the most abundant. Expressed at the neuromuscular junction of the extensor digitorum longus, tibialis anterior and soleus muscles. Expression at neuromuscular junctions is most pronounced in slow-twitch muscle. Also weakly expressed in heart, kidney, ovary and testis. Expression in extrasynaptic regions of muscle is induced by denervation. Expression in myoblasts is induced during differentiation into myotubes and by treatment with nerve derived trophic factors such as AGRN (agrin) and NRG1 (neuregulin). The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export. RNA binding double-stranded RNA binding nucleus nucleolus cytoplasm endoplasmic reticulum microtubule regulation of gene expression cytoplasmic stress granule kinesin binding axon dendrite Hsp70 protein binding nuclear membrane dendrite cytoplasm regulation of actin cytoskeleton organization ribosome binding neuronal cell body dendritic shaft eye morphogenesis mitogen-activated protein kinase binding regulation of filopodium assembly positive regulation of synapse assembly positive regulation of dendritic spine morphogenesis anterograde dendritic transport of messenger ribonucleoprotein complex positive regulation of long term synaptic depression messenger ribonucleoprotein complex uc007ajn.1 uc007ajn.2 uc007ajn.3 uc007ajn.4 
ENSMUST00000162752.2 Sh2d1b2 ENSMUST00000162752.2 SH2 domain containing 1B2 (from RefSeq NM_001033499.1) ENSMUST00000162752.1 Eat2b NM_001033499 Q45GR3 Q45HK4 SH21C_MOUSE Sh2d1c uc007dmb.1 uc007dmb.2 uc007dmb.3 Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family. In SLAM signaling may cooperate with Sh2d1a/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through Cd244/2b4. However, conflicting results are reported which may reflect the use of different strain backgrounds. Proposed to act as an inhibitor of Cd244-mediated NK cell function including cytotoxicity and IFN-gamma production, the latter found also by triggering Klra4 and Klrk1 next to Cd244 (PubMed:16127454). Seems to positively regulate Cd244- and Cd84-dependent NK cell functions implicating Cd244-mediated phosphorylation of Vav1 (PubMed:20962259). Interacts with SLAMF1 (phosphorylated). Interacts with CD244. Interacts with Src kinases HCK, LYN, FYN, FGR and LCK (via kinase domains). Cytoplasm Expressed in spleen. Expressed in macrophages, CD8(+) T-Cells and NK cells (PubMed:16425036). Conflictingly found only in NK cells (PubMed:16127454). adaptive immune response immune system process protein binding cellular_component cytoplasm peptidyl-tyrosine phosphorylation regulation of natural killer cell activation innate immune response negative regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity positive regulation of peptidyl-tyrosine phosphorylation uc007dmb.1 uc007dmb.2 uc007dmb.3 
ENSMUST00000162770.2 5330439A09Rik ENSMUST00000162770.2 5330439A09Rik (from geneSymbol) AK019937 ENSMUST00000162770.1 uc291zxm.1 uc291zxm.2 uc291zxm.1 uc291zxm.2 
ENSMUST00000162772.8 Lmo3 ENSMUST00000162772.8 LIM domain only 3, transcript variant 1 (from RefSeq NM_207222.4) ENSMUST00000162772.1 ENSMUST00000162772.2 ENSMUST00000162772.3 ENSMUST00000162772.4 ENSMUST00000162772.5 ENSMUST00000162772.6 ENSMUST00000162772.7 LMO3_MOUSE NM_207222 Q8BZL8 uc009enm.1 uc009enm.2 uc009enm.3 cytoplasm positive regulation of peroxisome proliferator activated receptor signaling pathway metal ion binding negative regulation of ERK1 and ERK2 cascade positive regulation of glucocorticoid receptor signaling pathway positive regulation of fat cell differentiation uc009enm.1 uc009enm.2 uc009enm.3 
ENSMUST00000162784.2 Gm16094 ENSMUST00000162784.2 Gm16094 (from geneSymbol) ENSMUST00000162784.1 KY467496 uc287jxh.1 uc287jxh.2 uc287jxh.1 uc287jxh.2 
ENSMUST00000162787.9 Osbpl9 ENSMUST00000162787.9 oxysterol binding protein-like 9, transcript variant a (from RefSeq NM_133885.4) E9PXZ2 E9PXZ2_MOUSE ENSMUST00000162787.1 ENSMUST00000162787.2 ENSMUST00000162787.3 ENSMUST00000162787.4 ENSMUST00000162787.5 ENSMUST00000162787.6 ENSMUST00000162787.7 ENSMUST00000162787.8 NM_133885 Osbpl9 uc008ucc.1 uc008ucc.2 uc008ucc.3 uc008ucc.4 Belongs to the OSBP family. lipid transport uc008ucc.1 uc008ucc.2 uc008ucc.3 uc008ucc.4 
ENSMUST00000162809.3 Tmem92 ENSMUST00000162809.3 transmembrane protein 92, transcript variant 1 (from RefSeq NM_001163172.1) B7ZWI3 E9Q2K3 ENSMUST00000162809.1 ENSMUST00000162809.2 NM_001163172 Q3UT21 TMM92_MOUSE uc029rno.1 uc029rno.2 uc029rno.3 Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B7ZWI3-1; Sequence=Displayed; Name=2; IsoId=B7ZWI3-2; Sequence=VSP_042507; molecular_function nucleoplasm biological_process membrane integral component of membrane uc029rno.1 uc029rno.2 uc029rno.3 
ENSMUST00000162819.9 Wdr26 ENSMUST00000162819.9 WD repeat domain 26, transcript variant 14 (from RefSeq NR_175392.1) E9PX83 ENSMUST00000162819.1 ENSMUST00000162819.2 ENSMUST00000162819.3 ENSMUST00000162819.4 ENSMUST00000162819.5 ENSMUST00000162819.6 ENSMUST00000162819.7 ENSMUST00000162819.8 NR_175392 Q3TK81 Q8C4F3 Q8C6G8 Q8VDZ6 WDR26_MOUSE uc007dxf.1 uc007dxf.2 uc007dxf.3 uc007dxf.4 uc007dxf.5 G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (By similarity). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity). Forms homooligomers. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with DDB1- CUL4A/B E3 ligase complexes. Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2. Interacts with AXIN1. Cytoplasm Nucleus Mitochondrion Sequence=BAC35923.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ubiquitin ligase complex molecular_function nucleus nucleoplasm cytoplasm mitochondrion cytosol biological_process uc007dxf.1 uc007dxf.2 uc007dxf.3 uc007dxf.4 uc007dxf.5 
ENSMUST00000162827.8 Zfp949 ENSMUST00000162827.8 zinc finger protein 949, transcript variant 1 (from RefSeq NM_001142943.1) E9Q732 E9Q732_MOUSE ENSMUST00000162827.1 ENSMUST00000162827.2 ENSMUST00000162827.3 ENSMUST00000162827.4 ENSMUST00000162827.5 ENSMUST00000162827.6 ENSMUST00000162827.7 NM_001142943 Zfp949 uc009qyu.1 uc009qyu.2 uc009qyu.3 uc009qyu.4 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc009qyu.1 uc009qyu.2 uc009qyu.3 uc009qyu.4 
ENSMUST00000162828.2 Gm15894 ENSMUST00000162828.2 Gm15894 (from geneSymbol) AK038870 ENSMUST00000162828.1 uc292der.1 uc292der.2 uc292der.1 uc292der.2 
ENSMUST00000162854.2 Kif6 ENSMUST00000162854.2 kinesin family member 6 (from RefSeq NM_177052.3) E9PX57 E9PX57_MOUSE ENSMUST00000162854.1 Kif6 NM_177052 uc008cyq.1 uc008cyq.2 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding male germ cell nucleus motor activity microtubule motor activity ATP binding kinesin complex microtubule microtubule-based movement microtubule binding ATPase activity uc008cyq.1 uc008cyq.2 
ENSMUST00000162868.2 A830011K09Rik ENSMUST00000162868.2 RIKEN cDNA A830011K09 gene, transcript variant 2 (from RefSeq NR_126073.1) ENSMUST00000162868.1 NR_126073 uc009enn.1 uc009enn.2 uc009enn.3 uc009enn.1 uc009enn.2 uc009enn.3 
ENSMUST00000162875.8 Cracdl ENSMUST00000162875.8 capping protein inhibiting regulator of actin like, transcript variant 5 (from RefSeq NM_028096.2) 2010300C02Rik Cracdl E9Q3M9 E9Q3M9_MOUSE ENSMUST00000162875.1 ENSMUST00000162875.2 ENSMUST00000162875.3 ENSMUST00000162875.4 ENSMUST00000162875.5 ENSMUST00000162875.6 ENSMUST00000162875.7 NM_028096 uc007arx.1 uc007arx.2 uc007arx.3 uc007arx.4 molecular_function cellular_component biological_process uc007arx.1 uc007arx.2 uc007arx.3 uc007arx.4 
ENSMUST00000162886.2 Mst1 ENSMUST00000162886.2 Belongs to the peptidase S1 family. Plasminogen subfamily. (from UniProt E0CXN0) AK040934 E0CXN0 E0CXN0_MOUSE ENSMUST00000162886.1 Mst1 uc292lbv.1 uc292lbv.2 Belongs to the peptidase S1 family. Plasminogen subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase activity proteolysis uc292lbv.1 uc292lbv.2 
ENSMUST00000162940.3 Smok2b ENSMUST00000162940.3 sperm motility kinase 2B (from RefSeq NM_001167913.2) ENSMUST00000162940.1 ENSMUST00000162940.2 Gm1847 NM_001167913 Q9QYZ3 SMK2B_MOUSE Smok2b uc012akm.1 uc012akm.2 uc012akm.3 uc012akm.4 May play a role in sperm motility, especially in the regulation of flagellar function. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Testis-specific. Expressed in the testis from 22 days postpartum (22 dpp). Encoded on the T-complex, a region of 20-30 Mb on proximal third of mouse chromosome 17. Naturally occurring variant forms of the T-complex, known as complete t-haplotypes, are found in wild mouse populations. The t-haplotypes contain at least four nonoverlapping inversions that suppress recombination with the wild- type chromosome, and lock into strong linkage disequilibrium loci affecting normal transmission of the chromosome, male gametogenesis and embryonic development. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity intracellular signal transduction uc012akm.1 uc012akm.2 uc012akm.3 uc012akm.4 
ENSMUST00000162945.2 Spata13 ENSMUST00000162945.2 spermatogenesis associated 13, transcript variant 9 (from RefSeq NM_001404954.1) E0CYU0 E0CYU0_MOUSE ENSMUST00000162945.1 NM_001404954 Spata13 uc007ufd.1 uc007ufd.2 uc007ufd.3 uc007ufd.4 uc007ufd.5 Cytoplasm guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity regulation of Rho protein signal transduction intracellular signal transduction uc007ufd.1 uc007ufd.2 uc007ufd.3 uc007ufd.4 uc007ufd.5 
ENSMUST00000162958.2 Gm16350 ENSMUST00000162958.2 Gm16350 (from geneSymbol) ENSMUST00000162958.1 uc291ylt.1 uc291ylt.2 uc291ylt.1 uc291ylt.2 
ENSMUST00000162961.8 Alkbh1 ENSMUST00000162961.8 alkB homolog 1, histone H2A dioxygenase (from RefSeq NM_001102565.1) ALKB1_MOUSE Abh Alkbh Alkbh1 ENSMUST00000162961.1 ENSMUST00000162961.2 ENSMUST00000162961.3 ENSMUST00000162961.4 ENSMUST00000162961.5 ENSMUST00000162961.6 ENSMUST00000162961.7 NM_001102565 P0CB42 uc007oix.1 uc007oix.2 uc007oix.3 uc007oix.4 Dioxygenase that acts as on nucleic acids, such as DNA and tRNA (PubMed:27027282, PubMed:27745969). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:27027282). A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment (By similarity). Mainly acts as a tRNA demethylase by removing N(1)- methyladenine from various tRNAs, with a preference for N(1)- methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs (PubMed:27745969). Acts as a regulator of translation initiation and elongation in response to glucose deprivation: regulates both translation initiation, by mediating demethylation of tRNA(Met), and translation elongation, N(1)-methyladenine-containing tRNAs being preferentially recruited to polysomes to promote translation elongation (By similarity). In mitochondrion, specifically interacts with mt- tRNA(Met) and mediates oxidation of mt-tRNA(Met) methylated at cytosine(34) to form 5-formylcytosine (f(5)c) at this position (By similarity). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (By similarity). Specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:27027282). N(6)- methyladenosine (m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing (PubMed:27027282). Demethylates mRNAs containing N(3)-methylcytidine modification (By similarity). Also able to repair alkylated single-stranded DNA by oxidative demethylation, but with low activity (By similarity). Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites (By similarity). DNA lyase activity does not require alpha-ketboglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product (By similarity). DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation (PubMed:23825659). May play a role in placental trophoblast lineage differentiation (PubMed:18163532). Reaction=2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:49524, Rhea:RHEA-COMP:12418, Rhea:RHEA-COMP:12419, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=1.14.11.51; Evidence=; Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA- COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695, ChEBI:CHEBI:167181; EC=4.2.99.18; Evidence=; Reaction=2-oxoglutarate + a methylated nucleobase within DNA + O2 = a nucleobase within DNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:30299, Rhea:RHEA-COMP:12192, Rhea:RHEA-COMP:12193, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:32875, ChEBI:CHEBI:64428; EC=1.14.11.33; Evidence=; Reaction=2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 = an adenosine in tRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:54576, Rhea:RHEA-COMP:10242, Rhea:RHEA-COMP:12312, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; Evidence=; Reaction=2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 = 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate; Xref=Rhea:RHEA:54144, Rhea:RHEA- COMP:13808, Rhea:RHEA-COMP:13809, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:74483, ChEBI:CHEBI:138075; Evidence=; Reaction=2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 = a cytidine in mRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:60920, Rhea:RHEA-COMP:15145, Rhea:RHEA-COMP:15713, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74894, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60921; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence= Note=Binds 1 Fe(2+) ion per subunit. Monomer (By similarity). Interacts with DNAJB6 (PubMed:18163532). P0CB42; O54946-2: Dnajb6; NbExp=2; IntAct=EBI-13941048, EBI-13941040; Nucleus Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli. In adult organs, highly expressed in testis, eye, brain and kidney. Weak expression throughout the embryo at 8.5 dpc. As the cells migrate and differentiate during organogenesis, expressed in the spinal cord, forebrain and branchial arches at 9.5 dpc, and also in limb buds at 10.5 dpc. Peak expression at 11.5 dpc in the frontonasal process including telencephalon, maxillary, mandibular and hyoid arches, upper and lower limb buds and midbrain and rhombomere 1 roof plates. Expression decreases considerably from 11.5 dpc to 12.5 dpc (PubMed:21072209). At 8.5 dpc is highly expressed in the chorion and the ectoplacental cone. At 10.5 dpc is highly expressed in multiple trophoblast lineages (spongiotrophoblasts, giant cell trophoblasts, glycogen cells, and labyrinthine trophoblasts). The highest placental level is at 9.5 dpc and subsequently decreases until parturition (PubMed:18163532). Deficiency results in 80% reduction of the litter size due to embryonic lethality (PubMed:21072209, PubMed:23825659). Surviving pups exhibit a gender bias in favor of males (70% males and 30% females) (PubMed:21072209, PubMed:23825659). Intrauterine growth retardation and placental defects. Altered expression of trophoblast lineage-specific genes (PubMed:18163532). Increased N(6)- methyladenosine (m6A) DNA (PubMed:27027282). No effect on H2AK118 or H2AK119 methylation, suggesting that Alkbh1 does not act as a histone demethylase in vivo (PubMed:27027282). Cells show an strong increase of N(1)-methyladenine-containing tRNAs (PubMed:27745969). H2A histone demethylase activity was observed in vitro (PubMed:22961808). The relevance of such activity is however unclear and additional experimental evidence would be needed to confirm this activity in vivo. The DNA N6-methyl adenine demethylase activity is subject to discussion. While DNA N6-methyl adenine demethylase activity was observed by a report (PubMed:27027282). Another group was unable to detect clear DNA N6-methyl adenine demethylase activity in vivo (PubMed:27745969). tRNA binding in utero embryonic development neuron migration placenta development tRNA wobble cytosine modification catalytic activity protein binding nucleus nuclear euchromatin mitochondrion DNA repair DNA dealkylation involved in DNA repair regulation of translation regulation of translational initiation regulation of translational elongation cellular response to DNA damage stimulus metabolic process ferrous iron binding regulation of gene expression oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors lyase activity cell differentiation neuron projection development oxidative DNA demethylation oxidative DNA demethylase activity chemoattractant activity RNA repair negative regulation of neuron apoptotic process metal ion binding developmental growth positive chemotaxis dioxygenase activity oxidation-reduction process regulation of mitochondrial translation methylcytosine dioxygenase activity oxidative demethylation DNA demethylation 1-ethyladenine demethylase activity tRNA demethylation tRNA demethylase activity uc007oix.1 uc007oix.2 uc007oix.3 uc007oix.4 
ENSMUST00000162964.9 Pramel34 ENSMUST00000162964.9 Belongs to the PRAME family. (from UniProt E0CZF1) AK139835 E0CZF1 E0CZF1_MOUSE E9PWI7 ENSMUST00000162964.1 ENSMUST00000162964.2 ENSMUST00000162964.3 ENSMUST00000162964.4 ENSMUST00000162964.5 ENSMUST00000162964.6 ENSMUST00000162964.7 ENSMUST00000162964.8 Pramel34 uc012dyx.1 uc012dyx.2 uc012dyx.3 uc012dyx.4 Belongs to the PRAME family. molecular_function cytoplasm biological_process uc012dyx.1 uc012dyx.2 uc012dyx.3 uc012dyx.4 
ENSMUST00000162973.8 Tle3 ENSMUST00000162973.8 transducin-like enhancer of split 3, transcript variant 2 (from RefSeq NM_009389.2) ENSMUST00000162973.1 ENSMUST00000162973.2 ENSMUST00000162973.3 ENSMUST00000162973.4 ENSMUST00000162973.5 ENSMUST00000162973.6 ENSMUST00000162973.7 Esg NM_009389 Q08122 Q6PHP0 Q923A4 TLE3_MOUSE uc009pzp.1 uc009pzp.2 uc009pzp.3 Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full- length TLE family members may be modulated by association with dominant-negative AES (By similarity). May play an important role during spermatogenesis. Homotetramer and heterooligomer with other family members. Binds FOXA2 (By similarity). Interacts with XIAP/BIRC4 (By similarity). Binds LEF1, TCF7, TCF7L1 and TCF7L2/TCF4. Interacts with TBX18 (via engrailed homology 1 repressor motif), leading to decreased of TBX18 transcriptional activity. Nucleus. Event=Alternative splicing; Named isoforms=4; Name=3; IsoId=Q08122-3; Sequence=Displayed; Name=1; IsoId=Q08122-1; Sequence=VSP_038441; Name=2; IsoId=Q08122-2; Sequence=VSP_007025; Name=4; IsoId=Q08122-4; Sequence=VSP_038442; Expressed only in testis (PubMed:8365415). Expressed in bone marrow-derived macrophages (PubMed:23990468). Repressed during TNFSF11/RANKL-induced osteoclast differentiation. WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N- terminal Q domain and the C-terminal WD-repeat domain. Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4. Belongs to the WD repeat Groucho/TLE family. transcription corepressor activity protein binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated multicellular organism development spermatogenesis Wnt signaling pathway cell differentiation repressing transcription factor binding negative regulation of canonical Wnt signaling pathway negative regulation of nucleic acid-templated transcription beta-catenin-TCF complex uc009pzp.1 uc009pzp.2 uc009pzp.3 
ENSMUST00000162998.2 Gm7247 ENSMUST00000162998.2 Gm7247 (from geneSymbol) AY358079 EG638695 ENSMUST00000162998.1 Gm7247 Q6UY52 Q6UY52_MOUSE uc288tou.1 uc288tou.2 molecular_function cellular_component biological_process uc288tou.1 uc288tou.2 
ENSMUST00000163009.3 Gm16315 ENSMUST00000163009.3 Gm16315 (from geneSymbol) ENSMUST00000163009.1 ENSMUST00000163009.2 uc287thr.1 uc287thr.2 uc287thr.3 uc287thr.1 uc287thr.2 uc287thr.3 
ENSMUST00000163017.10 Vgll2 ENSMUST00000163017.10 vestigial like family member 2, transcript variant 1 (from RefSeq NM_153786.2) ENSMUST00000163017.1 ENSMUST00000163017.2 ENSMUST00000163017.3 ENSMUST00000163017.4 ENSMUST00000163017.5 ENSMUST00000163017.6 ENSMUST00000163017.7 ENSMUST00000163017.8 ENSMUST00000163017.9 NM_153786 Q8BGW8 Q8BWB4 VGLL2_MOUSE Vgl2 Vito1 uc007fba.1 uc007fba.2 uc007fba.3 This gene is a member of the Vestigial-like (Vgl) gene family and is upregulated during muscle differentiation. The product of this gene interacts with and modifies the DNA-binding properties of the transcription factor, TEF-1, and is important for muscle tissue development. Reduced expression of this gene leads to a reduction in the terminal differentiation of muscle cells. Alternate splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]. May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles. Interacts with TEFs. Binds to TEAD1/TEF1. Nucleus Skeletal muscle specific. Expressed in the somitic myotome from 8.75 dpc mouse embryos onwards and later on in skeletal muscle but not in the heart. Additional expression domains during development are detected in the pharyngeal pouches and clefts starting at 8.0 dpc as well as in the cranial pharynx and in Rathkes pouch. Belongs to the vestigial family. transcription coactivator activity protein binding nucleus cytoplasm regulation of transcription, DNA-templated skeletal muscle tissue development protein C-terminus binding positive regulation of transcription from RNA polymerase II promoter uc007fba.1 uc007fba.2 uc007fba.3 
ENSMUST00000163048.8 Krr1 ENSMUST00000163048.8 KRR1, small subunit (SSU) processome component, homolog (yeast) (from RefSeq NM_178610.4) ENSMUST00000163048.1 ENSMUST00000163048.2 ENSMUST00000163048.3 ENSMUST00000163048.4 ENSMUST00000163048.5 ENSMUST00000163048.6 ENSMUST00000163048.7 Hrb2 KRR1_MOUSE NM_178610 Q3UIG9 Q52KQ6 Q5EBJ5 Q8BGA5 Q8C029 uc007hai.1 uc007hai.2 uc007hai.3 uc007hai.4 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Nucleus, nucleolus Belongs to the KRR1 family. Sequence=BAE27537.1; Type=Frameshift; Evidence=; nucleic acid binding RNA binding nucleus nucleolus cytoplasm rRNA processing small-subunit processome ribosome biogenesis intercellular bridge uc007hai.1 uc007hai.2 uc007hai.3 uc007hai.4 
ENSMUST00000163056.9 Gm5083 ENSMUST00000163056.9 predicted gene 5083 (from RefSeq NR_045285.1) ENSMUST00000163056.1 ENSMUST00000163056.2 ENSMUST00000163056.3 ENSMUST00000163056.4 ENSMUST00000163056.5 ENSMUST00000163056.6 ENSMUST00000163056.7 ENSMUST00000163056.8 NR_045285 uc007qgn.1 uc007qgn.2 uc007qgn.3 uc007qgn.4 uc007qgn.1 uc007qgn.2 uc007qgn.3 uc007qgn.4 
ENSMUST00000163069.2 Tbc1d22bos ENSMUST00000163069.2 TBC1 domain family, member 22B, opposite strand (from RefSeq NR_045447.1) ENSMUST00000163069.1 NR_045447 uc012aop.1 uc012aop.2 uc012aop.1 uc012aop.2 
ENSMUST00000163072.8 Ccdc150 ENSMUST00000163072.8 Ccdc150 (from geneSymbol) A0A571BEL4 A0A571BEL4_MOUSE AK029994 Ccdc150 ENSMUST00000163072.1 ENSMUST00000163072.2 ENSMUST00000163072.3 ENSMUST00000163072.4 ENSMUST00000163072.5 ENSMUST00000163072.6 ENSMUST00000163072.7 uc287idj.1 uc287idj.2 uc287idj.1 uc287idj.2 
ENSMUST00000163078.8 Ms4a6b ENSMUST00000163078.8 May be involved in signal transduction as a component of a multimeric receptor complex. (from UniProt Q99N09) AK172345 ENSMUST00000163078.1 ENSMUST00000163078.2 ENSMUST00000163078.3 ENSMUST00000163078.4 ENSMUST00000163078.5 ENSMUST00000163078.6 ENSMUST00000163078.7 M4A6B_MOUSE Q8BK83 Q99N09 Q9D8W9 uc289qza.1 uc289qza.2 May be involved in signal transduction as a component of a multimeric receptor complex. Membrane; Multi-pass membrane protein. Expressed at high levels in thymus, spleen, and peripheral lymph nodes, with less abundant levels in non-lymphoid tissues. Belongs to the MS4A family. molecular_function cellular_component biological_process membrane integral component of membrane uc289qza.1 uc289qza.2 
ENSMUST00000163080.3 1110002E22Rik ENSMUST00000163080.3 RIKEN cDNA 1110002E22 gene (from RefSeq NM_001370862.2) CD054_MOUSE E0CYV9 ENSMUST00000163080.1 ENSMUST00000163080.2 NM_001370862 uc290kbb.1 uc290kbb.2 molecular_function cellular_component biological_process uc290kbb.1 uc290kbb.2 
ENSMUST00000163089.2 Foxi3 ENSMUST00000163089.2 Nucleus (from UniProt A0A9S4I865) A0A9S4I865 A0A9S4I865_MOUSE ENSMUST00000163089.1 Foxi3 uc291fpt.1 uc291fpt.2 Nucleus uc291fpt.1 uc291fpt.2 
ENSMUST00000163096.2 Vmn1r251 ENSMUST00000163096.2 vomeronasal 1 receptor 251 (from RefSeq NM_001167152.1) ENSMUST00000163096.1 Gm6164 Gm8653 K9J7G2 K9J7G2_MOUSE NM_001167152 Vmn1r241 Vmn1r251 uc012fdu.1 uc012fdu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fdu.1 uc012fdu.2 
ENSMUST00000163118.2 Itih1 ENSMUST00000163118.2 inter-alpha trypsin inhibitor, heavy chain 1, transcript variant 1 (from RefSeq NM_008406.3) ENSMUST00000163118.1 ITIH1_MOUSE NM_008406 Q3UEI9 Q61702 uc007svz.1 uc007svz.2 This gene encodes a heavy chain of inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors. IaI proteins are protein-glycosaminoglycan-protein complexes comprised of two heavy chains and a light chain. The encoded protein covalently associates with the light chain via a chondroitin sulfate moiety. Intravenous administration of the encoded protein improved survival of mice after infection with Escherichia coli. This gene is located adjacent to two other IaI heavy chain genes. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature protein. [provided by RefSeq, Oct 2015]. May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha- inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin. Interacts with TNFAIP6 (via Link and CUB domains). Secreted. Liver specific. Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage. The S-linked glycan is composed of two 6-carbon sugars, possibly Glc or Gal. Belongs to the ITIH family. serine-type endopeptidase inhibitor activity protein binding extracellular region negative regulation of peptidase activity negative regulation of endopeptidase activity extracellular matrix organization hyaluronan metabolic process peptidase inhibitor activity extracellular matrix uc007svz.1 uc007svz.2 
ENSMUST00000163119.8 Cul3 ENSMUST00000163119.8 cullin 3, transcript variant 1 (from RefSeq NM_016716.6) CUL3_MOUSE ENSMUST00000163119.1 ENSMUST00000163119.2 ENSMUST00000163119.3 ENSMUST00000163119.4 ENSMUST00000163119.5 ENSMUST00000163119.6 ENSMUST00000163119.7 NM_016716 Q9JLV5 uc007brc.1 uc007brc.2 uc007brc.3 uc007brc.4 Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (By similarity). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component (By similarity). BCR(KLHL42) is involved in ubiquitination of KATNA1 (By similarity). BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3 (By similarity). Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity (By similarity). BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity). BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 (By similarity). The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (By similarity). The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (By similarity). The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway (By similarity). The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) (By similarity). The BCR(KLHL25) ubiquitin ligase complex is also involved in lipid synthesis by mediating ubiquitination and degradation of ACLY (PubMed:34491895). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification (By similarity). Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition (By similarity). Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity). In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (By similarity). The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (By similarity). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (By similarity). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (By similarity). The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:12193649, PubMed:14764894, PubMed:15282312). As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions mediates 'Lys-48' ubiquitination and proteasomal degradation of TIAM1. By controlling the ubiquitination of that RAC1 guanine exchange factors (GEF), regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (By similarity). Protein modification; protein ubiquitination. Forms neddylation-dependent homodimers (By similarity). Component of multiple BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes formed of CUL3, RBX1 and a variable BTB domain-containing protein acting as both, adapter to cullin and substrate recognition subunit (By similarity). The BCR complex may be active as a heterodimeric complex, in which NEDD8, covalently attached to one CUL3 molecule, binds to the C-terminus of a second CUL3 molecule (By similarity). Interacts with RBX1, RNF7 and TIP120A/CAND1 (By similarity). Part of the BCR(SPOP) containing SPOP, and of BCR containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL (By similarity). Part of the probable BCR(KLHL9-KLHL13) complex with BTB domain proteins KLHL9 and KLHL13 (By similarity). Part of the BCR(KLHL41) complex containing KLHL41 (By similarity). Component of the BCR(KLHL12) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1 (By similarity). Component of the BCR(KLHL3) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL3 and RBX1 (By similarity). Part of the BCR(ENC1) complex containing ENC1 (By similarity). Part of a complex consisting of BMI1/PCGF4, CUL3 and SPOP (By similarity). Part of a complex consisting of BRMS1, CUL3 and SPOP (By similarity). Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1 (By similarity). Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1 (By similarity). Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL25 and RBX1 (PubMed:34491895). Part of a complex consisting of MACROH2A1, CUL3 and SPOP (By similarity). Component of the BCR(KLHL42) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL42 (By similarity). Component of the BCR(KBTBD8) E3 ubiquitin ligase complex, at least composed of CUL3, KBTBD8 and RBX1 (By similarity). Interacts with KLHL42 (via the BTB domain) (By similarity). Interacts with KATNA1; the interaction is enhanced by KLHL42 (By similarity). Interacts with KCTD5, KLHL9, KLHL11, KLHL13, GAN, ZBTB16, KLHL3, KLHL15, KLHL20, KLHL36, GMCL2, BTBD1 (By similarity). Part of a complex that contains CUL3, RBX1 and GAN (By similarity). Interacts (via BTB domain) with KLHL17; the interaction regulates surface GRIK2 expression (By similarity). Interacts with KCTD7 (By similarity). Part of the BCR(GAN) complex containing GAN (By similarity). Part of the BCR(KEAP1) complex containing KEAP1 (PubMed:15282312, PubMed:16790436, PubMed:27697860). Interacts with KAT5 and ATF2 (By similarity). Interacts with KCTD17 in the BCR(KCTD17) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD17 and RBX1 (By similarity). Interacts (when neddylated) with ARIH1; leading to activate the E3 ligase activity of ARIH1 (By similarity). Interacts with COPS9 (By similarity). Interacts with PPP2R5B; this interaction is indirect and mediated through KLHL15-binding and leads to PPP2R5B proteasomal degradation (By similarity). Interacts with RBBP8/CtIP; this interaction is indirect and mediated through KLHL15-binding and leads to RBBP8 proteasomal degradation (By similarity). Interacts with KLHL24 in the BCR(KLHL24) E3 ubiquitin ligase complex, composed of CUL3, RBX1 and KLHL24 (By similarity). Interacts with RHOBTB2 (By similarity). Interacts with CYCE (PubMed:10500095). Interacts with KLHL10 (PubMed:16162871). Interacts with AURKA and KLHL18 (via BTB domain) (By similarity). Interacts (unneddylated form) with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5; these interactions promote the cullin neddylation (By similarity). Component of a BCR3 (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, also named Cul3-RING ubiquitin ligase complex CUL3(KBTBD6/7), composed of CUL3, RBX1, KBTBD6 and KBTBD7 (By similarity). Component of the BCR(KBTBD2) E3 ubiquitin ligase complex, at least composed of CUL3, KBTBD2 and RBX1. Interacts with KBTBD2 (via the BTB domain) (PubMed:27708159). Nucleus Golgi apparatus Cell projection, cilium, flagellum Cytoplasm Cytoplasm, cytoskeleton, spindle Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Note=Detected along the length of the sperm flagellum and in the cytoplasm of the germ cells. Predominantly found in the nucleus in interphase cells, found at the centrosome at late G2 or prophase, starts accumulating at the spindle poles in prometaphase and stays on the spindle poles and the mitotic spindle at metaphase. Widely expressed, with highest expression in brain, spleen and testis. In the testis, it is mainly expressed in spermatids. Neddylated. Attachment of NEDD8 is required for the E3 ubiquitin- protein ligase activity of the BCR complex. Deneddylated via its interaction with the COP9 signalosome (CSN) complex. Null deficient mice are not viable. Extraembryonic ectoderm shows a greatly increased number of cells in S phase. In the trophectoderm cells are blocked to entry into S phase. Embryonic stem (ES) cells form tightly packed cell clusters with prominent actin cables and aberrant adhesions. ES cells are retained in proliferation, yet retain their pluripotency. Belongs to the cullin family. negative regulation of transcription from RNA polymerase II promoter Golgi membrane protein polyubiquitination mitotic cell cycle cell morphogenesis spindle pole in utero embryonic development trophectodermal cellular morphogenesis ubiquitin-protein transferase activity Notch binding protein binding nucleus cytoplasm Golgi apparatus centrosome polar microtubule cilium regulation of transcription from RNA polymerase II promoter ubiquitin-dependent protein catabolic process protein monoubiquitination ER to Golgi vesicle-mediated transport mitotic metaphase plate congression integrin-mediated signaling pathway gastrulation Wnt signaling pathway vesicle-mediated transport cell migration protein ubiquitination stem cell division cell projection organization cyclin binding anaphase-promoting complex-dependent catabolic process POZ domain binding positive regulation of protein ubiquitination cullin-RING ubiquitin ligase complex Cul3-RING ubiquitin ligase complex motile cilium ubiquitin protein ligase binding protein destabilization positive regulation of cytokinesis negative regulation of Rho protein signal transduction sperm flagellum embryonic cleavage protein homodimerization activity cell projection stress fiber assembly proteasome-mediated ubiquitin-dependent protein catabolic process fibroblast apoptotic process positive regulation of mitotic metaphase/anaphase transition protein heterodimerization activity COPII vesicle coating nucleus-associated proteasomal ubiquitin-dependent protein catabolic process liver morphogenesis mitotic spindle positive regulation of mitotic cell cycle phase transition uc007brc.1 uc007brc.2 uc007brc.3 uc007brc.4 
ENSMUST00000163121.8 Gbgt1 ENSMUST00000163121.8 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, transcript variant 1 (from RefSeq NM_139197.3) ENSMUST00000163121.1 ENSMUST00000163121.2 ENSMUST00000163121.3 ENSMUST00000163121.4 ENSMUST00000163121.5 ENSMUST00000163121.6 ENSMUST00000163121.7 Fgs GBGT1_MOUSE Gbgt1 NM_139197 Q3KPA1 Q8CJF3 Q8VI38 uc008iyl.1 uc008iyl.2 uc008iyl.3 Catalyzes the formation of Forssman glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to GalNAcb-1,3Gala-1,4Galb-1,4GlcCer (Gb4Cer) (PubMed:14573676). Forssman glycolipid (also called Forssman antigen; FG) probably serves for adherence of some pathogens (PubMed:14573676). Conversely, it diminishes Shiga toxins susceptibility (PubMed:14573676). Reaction=a globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D- galactosamine = a globoside Forssman (d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:22164, ChEBI:CHEBI:15378, ChEBI:CHEBI:18056, ChEBI:CHEBI:18259, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.88; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22165; Evidence=; Reaction=a globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine = a globoside IV3GalNAc-Gb4Cer + H(+) + UDP; Xref=Rhea:RHEA:56568, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:88167, ChEBI:CHEBI:90400; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56569; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mn(2+) ion per subunit. ; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity). Belongs to the glycosyltransferase 6 family. Name=Functional Glycomics Gateway - GTase; Note=Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; URL="http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=gt_mou_504"; Golgi membrane Golgi apparatus carbohydrate metabolic process protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups lipid glycosylation vesicle metal ion binding globoside alpha-N-acetylgalactosaminyltransferase activity uc008iyl.1 uc008iyl.2 uc008iyl.3 
ENSMUST00000163123.3 Slc8a1 ENSMUST00000163123.3 solute carrier family 8 (sodium/calcium exchanger), member 1, transcript variant A (from RefSeq NM_011406.3) ENSMUST00000163123.1 ENSMUST00000163123.2 G3X9J1 G3X9J1_MOUSE NM_011406 Slc8a1 uc008drs.1 uc008drs.2 uc008drs.3 uc008drs.4 Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in); Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108; Evidence=; Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. calcium:sodium antiporter activity calcium ion transport cell communication membrane integral component of membrane sodium ion transmembrane transport transmembrane transport uc008drs.1 uc008drs.2 uc008drs.3 uc008drs.4 
ENSMUST00000163134.8 Nrxn3 ENSMUST00000163134.8 neurexin III, transcript variant 11 (from RefSeq NM_001422396.1) E9PW93 E9Q466 ENSMUST00000163134.1 ENSMUST00000163134.2 ENSMUST00000163134.3 ENSMUST00000163134.4 ENSMUST00000163134.5 ENSMUST00000163134.6 ENSMUST00000163134.7 NM_001422396 NRX3A_MOUSE Q6P9K9 Q8CCT8 uc033ger.1 uc033ger.2 uc033ger.3 Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). The laminin G-like domain 2 binds to NXPH1 (By similarity). Specific isoforms bind to alpha-dystroglycan (By similarity). The cytoplasmic C-terminal region binds to CASK (By similarity). Specific isoforms bind neuroligins NLGN1, NLGN2 and NLGN3 (By similarity). Interacts with CLSTN3 (PubMed:24094106, PubMed:24613359, PubMed:32434929). Q6P9K9; O14522: PTPRT; Xeno; NbExp=2; IntAct=EBI-7281557, EBI-728180; Presynaptic cell membrane ; Single-pass type I membrane protein Event=Alternative promoter usage, Alternative splicing; Named isoforms=3; Comment=A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus.; Name=1a; IsoId=Q6P9K9-1; Sequence=Displayed; Name=2a; IsoId=Q6P9K9-2; Sequence=VSP_041710, VSP_041711, VSP_041712; Name=1b; IsoId=Q8C985-1; Sequence=External; Brain and arteries (at protein level). O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins. [Isoform 2a]: Produced by alternative splicing. Belongs to the neurexin family. Sequence=AAH60719.1; Type=Miscellaneous discrepancy; Note=Contains an insert which is not supported by any other transcript and which does not match with the genome.; Evidence=; calcium channel regulator activity protein binding cell adhesion chemical synaptic transmission neurotransmitter secretion synapse assembly membrane integral component of membrane macromolecular complex presynaptic membrane metal ion binding GABA-ergic synapse regulation of synaptic vesicle exocytosis uc033ger.1 uc033ger.2 uc033ger.3 
ENSMUST00000163139.8 Plxna1 ENSMUST00000163139.8 plexin A1 (from RefSeq NM_008881.2) B2RQP7 ENSMUST00000163139.1 ENSMUST00000163139.2 ENSMUST00000163139.3 ENSMUST00000163139.4 ENSMUST00000163139.5 ENSMUST00000163139.6 ENSMUST00000163139.7 Kiaa4053 NM_008881 P70206 PLXA1_MOUSE Q5DTR0 uc009cwg.1 uc009cwg.2 uc009cwg.3 uc009cwg.4 uc009cwg.5 Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Interacts with CRMP1, DPYSL2/CRMP2, DPYSL3/CRMP3 and DPYSL4/CRMP4. P70206; Q8BNV8: A530064D06Rik; NbExp=3; IntAct=EBI-771260, EBI-15687021; P70206; P97333: Nrp1; NbExp=4; IntAct=EBI-771260, EBI-1555129; P70206; Q99NH8: Trem2; NbExp=4; IntAct=EBI-771260, EBI-15982016; Cell membrane; Single-pass type I membrane protein. Ubiquitous. Belongs to the plexin family. semaphorin receptor complex protein binding plasma membrane integral component of plasma membrane negative regulation of cell adhesion signal transduction regulation of cell shape regulation of smooth muscle cell migration membrane integral component of membrane semaphorin receptor activity regulation of cell migration regulation of GTPase activity positive regulation of axonogenesis dichotomous subdivision of terminal units involved in salivary gland branching semaphorin-plexin signaling pathway neuron projection guidance semaphorin-plexin signaling pathway involved in axon guidance neuron projection extension uc009cwg.1 uc009cwg.2 uc009cwg.3 uc009cwg.4 uc009cwg.5 
ENSMUST00000163153.9 Rdx ENSMUST00000163153.9 radixin, transcript variant 2 (from RefSeq NM_001104616.1) ENSMUST00000163153.1 ENSMUST00000163153.2 ENSMUST00000163153.3 ENSMUST00000163153.4 ENSMUST00000163153.5 ENSMUST00000163153.6 ENSMUST00000163153.7 ENSMUST00000163153.8 NM_001104616 P26043 Q3TS85 Q9QW27 RADI_MOUSE uc009plq.1 uc009plq.2 uc009plq.3 uc009plq.4 Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (PubMed:12522145). Binds NHERF1 (By similarity). Interacts with LAYN (PubMed:15913605). Interacts with NHERF1 and NHERF2 (PubMed:16615918). Interacts with MME/NEP (PubMed:17459884). Interacts with ICAM2 (PubMed:12554651, PubMed:9472040). Interacts (via FERM domain) with SPN/CD43 cytoplasmic tail (PubMed:9472040, PubMed:18614175). Interacts with CD44 (PubMed:9472040). P26043; P35330: Icam2; NbExp=2; IntAct=EBI-647737, EBI-1035485; P26043; O14745: NHERF1; Xeno; NbExp=2; IntAct=EBI-647737, EBI-349787; P26043; Q15599: NHERF2; Xeno; NbExp=2; IntAct=EBI-647737, EBI-1149760; Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cell projection, microvillus Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively. The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ability to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN. Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C- terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. ruffle actin binding protein binding cytoplasm cytoskeleton plasma membrane microvillus cell-cell adherens junction focal adhesion cytoskeletal protein binding regulation of cell shape regulation of cell size positive regulation of gene expression membrane apical plasma membrane protein domain specific binding lamellipodium microvillus assembly filopodium T-tubule positive regulation of cell migration midbody cortical actin cytoskeleton cleavage furrow regulation of actin filament bundle assembly stereocilium negative regulation of homotypic cell-cell adhesion negative regulation of GTPase activity cellular response to platelet-derived growth factor stimulus protein homodimerization activity cell projection regulation of GTPase activity myelin sheath apical protein localization apical part of cell establishment of protein localization negative regulation of cell size barbed-end actin filament capping ATPase binding cell tip actin filament capping establishment of endothelial barrier cell periphery protein localization to plasma membrane cellular response to thyroid hormone stimulus regulation of ruffle assembly positive regulation of G1/S transition of mitotic cell cycle regulation of organelle assembly positive regulation of protein localization to early endosome positive regulation of cellular protein catabolic process negative regulation of adherens junction organization positive regulation of early endosome to late endosome transport uc009plq.1 uc009plq.2 uc009plq.3 uc009plq.4 
ENSMUST00000163172.2 Tex54 ENSMUST00000163172.2 testis expressed 54 (from RefSeq NM_001177347.1) ENSMUST00000163172.1 G3UW99 NM_001177347 TEX54_MOUSE Tex54 uc008gmn.1 uc008gmn.2 uc008gmn.3 Expressed in Testis. molecular_function cellular_component biological_process uc008gmn.1 uc008gmn.2 uc008gmn.3 
ENSMUST00000163194.2 Gm17112 ENSMUST00000163194.2 Gm17112 (from geneSymbol) ENSMUST00000163194.1 uc291awn.1 uc291awn.2 uc291awn.1 uc291awn.2 
ENSMUST00000163196.2 Gm17041 ENSMUST00000163196.2 Gm17041 (from geneSymbol) ENSMUST00000163196.1 uc292ktf.1 uc292ktf.2 uc292ktf.1 uc292ktf.2 
ENSMUST00000163199.5 Nme9 ENSMUST00000163199.5 May be a regulator of microtubule physiology. (from UniProt A0A1L1SUL6) A0A1L1SUL6 BC068205 ENSMUST00000163199.1 ENSMUST00000163199.2 ENSMUST00000163199.3 ENSMUST00000163199.4 Nme9 TXND6_MOUSE Txl2 Txndc6 uc292jyr.1 uc292jyr.2 May be a regulator of microtubule physiology. Monomer and homodimer. Cytoplasm, cytoskeleton, cilium axoneme Dynein axonemal particle Note=Associated with microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette. Expressed in lung airway epithelium (at protein level). Belongs to the NDK family. molecular_function nucleoside diphosphate kinase activity cellular_component cell nucleoside diphosphate phosphorylation GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process biological_process cell redox homeostasis uc292jyr.1 uc292jyr.2 
ENSMUST00000163238.9 Mdm1 ENSMUST00000163238.9 transformed mouse 3T3 cell double minute 1, transcript variant 3 (from RefSeq NM_001162904.1) B2RPU6 B2RPU6_MOUSE ENSMUST00000163238.1 ENSMUST00000163238.2 ENSMUST00000163238.3 ENSMUST00000163238.4 ENSMUST00000163238.5 ENSMUST00000163238.6 ENSMUST00000163238.7 ENSMUST00000163238.8 Mdm1 NM_001162904 uc011xnr.1 uc011xnr.2 uc011xnr.3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Belongs to the MDM1 family. nucleus centrosome centriole cytosol microtubule binding photoreceptor cell maintenance negative regulation of centriole replication uc011xnr.1 uc011xnr.2 uc011xnr.3 
ENSMUST00000163242.3 Atxn10 ENSMUST00000163242.3 ataxin 10 (from RefSeq NM_016843.4) ATX10_MOUSE ENSMUST00000163242.1 ENSMUST00000163242.2 NM_016843 P28658 Q543S3 Q99LP5 Q9D1I1 Sca10 uc007xdd.1 uc007xdd.2 uc007xdd.3 Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. Homooligomer (By similarity). Interacts with GNB2 (By similarity). Interacts with OGT. Interacts with IQCB1 (By similarity). P28658; Q8BP00: Iqcb1; NbExp=2; IntAct=EBI-4284019, EBI-4282243; Cytoplasm, perinuclear region In high cell density areas; cerebellar cortex, dentate gyrus, hippocampus, anterior olfactory nucleus, primary olfactory cortex. Belongs to the ataxin-10 family. Sequence=CAA43722.1; Type=Frameshift; Evidence=; molecular_function protein binding cellular_component cytoplasm cytosol plasma membrane nervous system development enzyme binding dendrite neuron projection development identical protein binding neuronal cell body perinuclear region of cytoplasm cilium assembly protein homotrimerization uc007xdd.1 uc007xdd.2 uc007xdd.3 
ENSMUST00000163245.2 Gm20507 ENSMUST00000163245.2 Gm20507 (from geneSymbol) AK076291 ENSMUST00000163245.1 uc289jvf.1 uc289jvf.2 uc289jvf.1 uc289jvf.2 
ENSMUST00000163255.9 Trim43c ENSMUST00000163255.9 tripartite motif-containing 43C (from RefSeq NM_001177858.1) ENSMUST00000163255.1 ENSMUST00000163255.2 ENSMUST00000163255.3 ENSMUST00000163255.4 ENSMUST00000163255.5 ENSMUST00000163255.6 ENSMUST00000163255.7 ENSMUST00000163255.8 NM_001177858 P86449 TR43C_MOUSE Trim43c uc012gyb.1 uc012gyb.2 Expression is restricted to preimplantation embryos and peaks at the 8-cell to morula stage. Belongs to the TRIM/RBCC family. cellular_component biological_process zinc ion binding metal ion binding uc012gyb.1 uc012gyb.2 
ENSMUST00000163257.9 Arb2a ENSMUST00000163257.9 ARB2 cotranscriptional regulator A, transcript variant 1 (from RefSeq NM_138312.1) ARB2A_MOUSE ENSMUST00000163257.1 ENSMUST00000163257.2 ENSMUST00000163257.3 ENSMUST00000163257.4 ENSMUST00000163257.5 ENSMUST00000163257.6 ENSMUST00000163257.7 ENSMUST00000163257.8 Fam172a NM_138312 Q3TLW0 Q3TNH5 uc011zcc.1 uc011zcc.2 uc011zcc.3 Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface (PubMed:29311329). May have hydrolase activity (PubMed:29311329). Interacts with AGO2 (PubMed:29311329). Found in a complex, composed of AGO2, CHD7 and ARB2A (PubMed:29311329). Nucleus Cytoplasm Endoplasmic reticulum Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TNH5-1; Sequence=Displayed; Name=2; IsoId=Q3TNH5-2; Sequence=VSP_031750; Name=3; IsoId=Q3TNH5-3; Sequence=VSP_031751, VSP_031752; Widely expressed during development. Homozygotes deficient mice die before postnatal day 25. Mice display retinal coloboma, cleft palate, and hypoplastic semicircular canals, retarded growth, genital anomalies and malformation of the heart and cranial nerves. Mice display a complex phenotype mimicking both the major and minor features of CHARGE syndrome (CHARGES). Belongs to the ARB2A family. regulation of alternative mRNA splicing, via spliceosome protein binding nucleus cytoplasm endoplasmic reticulum mRNA processing RNA splicing neural crest cell development chromatin silencing by small RNA siRNA binding uc011zcc.1 uc011zcc.2 uc011zcc.3 
ENSMUST00000163273.2 Gm17178 ENSMUST00000163273.2 Gm17178 (from geneSymbol) ENSMUST00000163273.1 uc288eio.1 uc288eio.2 uc288eio.1 uc288eio.2 
ENSMUST00000163279.6 Sh3glb1 ENSMUST00000163279.6 SH3-domain GRB2-like B1 (endophilin), transcript variant 2 (from RefSeq NM_019464.3) ENSMUST00000163279.1 ENSMUST00000163279.2 ENSMUST00000163279.3 ENSMUST00000163279.4 ENSMUST00000163279.5 Kiaa0491 NM_019464 Q3TYR7 Q6A059 Q8CDS9 Q8VI52 Q9CT31 Q9JK48 SHLB1_MOUSE uc008rpv.1 uc008rpv.2 uc008rpv.3 uc008rpv.4 May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells (PubMed:17086176). May recruit other proteins to membranes with high curvature. May promote membrane fusion (By similarity). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (PubMed:24523556). Involved in caspase- independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (PubMed:24523556). Homodimer, and heterodimer with SH3GLB2 (By similarity). Binds BAX; induction of apoptosis augments BAX binding (PubMed:16227588, PubMed:17381077). Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1 (PubMed:12456676, PubMed:17086176). Interacts with UVRAG; UVRAG bridges the interaction to BECN1 indicative for an association with the PI3K complex II (PI3KC3-C2) (By similarity). Isoform 3 interacts with PPP1CC; this interaction leads to the inhibition of phosphatase activity (PubMed:17381077). Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein Mitochondrion outer membrane ; Peripheral membrane protein Cytoplasmic vesicle, autophagosome membrane Midbody Note=Association with the Golgi apparatus depends on the cell type. Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Endophilin B1a, Bif-1 ; IsoId=Q9JK48-1; Sequence=Displayed; Name=2; Synonyms=Endophilin B1b; IsoId=Q9JK48-2; Sequence=VSP_009277; Name=3; Synonyms=Endophilin-B1t ; IsoId=Q9JK48-3; Sequence=VSP_058266; Isoform 1 is widely expressed. Isoform 2 is brain- specific. Isoform 3 is predominantly expressed in testis, but it is also detected in liver and, at much lower levels, in skin, stomach and ovary. An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The SH3 domain is required and sufficient for the interaction with UVRAG. Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization. Fibroblasts with a reduced level of Sh3glb1 show a defect in retrograde transport between the Golgi apparatus and the endoplasmic reticulum. Belongs to the endophilin family. Was originally thought to have lysophosphatidic acid acyltransferase activity, but by homology with SH3GL2/endophilin A1 is unlikely to have this activity. Sequence=BAD32237.1; Type=Erroneous initiation; Evidence=; Golgi membrane autophagosome membrane fatty acid binding protein binding cytoplasm mitochondrion mitochondrial envelope mitochondrial outer membrane early endosome endoplasmic reticulum Golgi apparatus cytosol phosphatidic acid biosynthetic process apoptotic process mitochondrion organization synaptic vesicle lipid binding phospholipid biosynthetic process positive regulation of autophagy membrane midbody cytoplasmic vesicle positive regulation of protein oligomerization regulation of cytokinesis receptor catabolic process macromolecular complex cellular response to amino acid starvation cellular response to glucose starvation lysophosphatidic acid acyltransferase activity identical protein binding protein homodimerization activity neuron projection neuronal cell body positive regulation of phosphatidylinositol 3-kinase activity autophagic cell death positive regulation of dendrite morphogenesis 'de novo' posttranslational protein folding protein oligomerization positive regulation of neurotrophin TRK receptor signaling pathway membrane fission positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of membrane tubulation protein localization to vacuolar membrane positive regulation of dendrite extension regulation of early endosome to late endosome transport positive regulation of autophagosome assembly uc008rpv.1 uc008rpv.2 uc008rpv.3 uc008rpv.4 
ENSMUST00000163289.7 Fan1 ENSMUST00000163289.7 FANCD2/FANCI-associated nuclease 1 (from RefSeq NM_177893.4) ENSMUST00000163289.1 ENSMUST00000163289.2 ENSMUST00000163289.3 ENSMUST00000163289.4 ENSMUST00000163289.5 ENSMUST00000163289.6 FAN1_MOUSE Fan1 Kiaa1018 Mtmr15 NM_177893 Q14B88 Q69ZT1 Q8BVK2 uc012fmp.1 uc012fmp.2 uc012fmp.3 Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (By similarity). Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (PubMed:24981866). Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (By similarity). Also has endonuclease activity toward 5'-flaps (PubMed:24981866). Reaction=Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.; EC=3.1.4.1; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit. ; Interacts with FANCD2 (when monoubiquitinated). Interacts with FANCI, MLH1, MLH3 and PMS2. Nucleus Note=Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2. Localizes to stalled replication forks via its UBZ4-type zinc finger. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q69ZT1-1; Sequence=Displayed; Name=2; IsoId=Q69ZT1-2; Sequence=VSP_029435, VSP_029436; Name=3; IsoId=Q69ZT1-3; Sequence=VSP_029432, VSP_029433; Name=4; IsoId=Q69ZT1-4; Sequence=VSP_029431, VSP_029434; The UBZ4-type zinc finger specifically binds monoubiquitinated FANCD2. The KEN box and D-box are required for interaction with FZR1/CDH1 and essential for APC(CDH1)-mediated ubiquitination. Ubiquitinated and degraded during mitotic exit by the APC/C-Cdh1 complex. Belongs to the FAN1 family. double-strand break repair via homologous recombination nucleic acid binding nuclease activity endonuclease activity exonuclease activity phosphodiesterase I activity nucleus nucleoplasm cytosol DNA repair nucleotide-excision repair cellular response to DNA damage stimulus 5'-3' exonuclease activity hydrolase activity hydrolase activity, acting on ester bonds 5'-flap endonuclease activity nucleotide-excision repair, DNA incision interstrand cross-link repair intercellular bridge metal ion binding flap-structured DNA binding uc012fmp.1 uc012fmp.2 uc012fmp.3 
ENSMUST00000163301.8 Zfp454 ENSMUST00000163301.8 zinc finger protein 454, transcript variant 1 (from RefSeq NM_172794.3) ENSMUST00000163301.1 ENSMUST00000163301.2 ENSMUST00000163301.3 ENSMUST00000163301.4 ENSMUST00000163301.5 ENSMUST00000163301.6 ENSMUST00000163301.7 NM_172794 Q80Y34 Q80Y34_MOUSE Zfp454 uc287xxo.1 uc287xxo.2 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc287xxo.1 uc287xxo.2 
ENSMUST00000163325.8 Gm9602 ENSMUST00000163325.8 Gm9602 (from geneSymbol) ENSMUST00000163325.1 ENSMUST00000163325.2 ENSMUST00000163325.3 ENSMUST00000163325.4 ENSMUST00000163325.5 ENSMUST00000163325.6 ENSMUST00000163325.7 Gm9602 L7N276 L7N276_MOUSE uc288qkq.1 uc288qkq.2 molecular_function cellular_component biological_process uc288qkq.1 uc288qkq.2 
ENSMUST00000163336.8 Ncoa4 ENSMUST00000163336.8 nuclear receptor coactivator 4, transcript variant 17 (from RefSeq NM_001403011.1) ENSMUST00000163336.1 ENSMUST00000163336.2 ENSMUST00000163336.3 ENSMUST00000163336.4 ENSMUST00000163336.5 ENSMUST00000163336.6 ENSMUST00000163336.7 NM_001403011 Ncoa4 Q5U4H9 Q5U4H9_MOUSE uc007syj.1 uc007syj.2 uc007syj.3 uc007syj.4 molecular_function transcription coactivator activity mitochondrion protein targeting to lysosome cellular iron ion homeostasis response to hormone autolysosome positive regulation of nucleic acid-templated transcription uc007syj.1 uc007syj.2 uc007syj.3 uc007syj.4 
ENSMUST00000163338.2 Luzp4 ENSMUST00000163338.2 leucine zipper protein 4 (from RefSeq NM_001114383.1) ENSMUST00000163338.1 L7N278 L7N278_MOUSE Luzp4 NM_001114383 uc012hqi.1 uc012hqi.2 molecular_function cellular_component biological_process uc012hqi.1 uc012hqi.2 
ENSMUST00000163348.8 Zfp426 ENSMUST00000163348.8 zinc finger protein 426, transcript variant 3 (from RefSeq NM_001310742.1) ENSMUST00000163348.1 ENSMUST00000163348.2 ENSMUST00000163348.3 ENSMUST00000163348.4 ENSMUST00000163348.5 ENSMUST00000163348.6 ENSMUST00000163348.7 G5E8Y1 G5E8Y1_MOUSE NM_001310742 Zfp426 uc009oit.1 uc009oit.2 uc009oit.3 uc009oit.4 uc009oit.5 uc009oit.6 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009oit.1 uc009oit.2 uc009oit.3 uc009oit.4 uc009oit.5 uc009oit.6 
ENSMUST00000163370.8 Tiam1 ENSMUST00000163370.8 T cell lymphoma invasion and metastasis 1, transcript variant 6 (from RefSeq NM_001426933.1) ENSMUST00000163370.1 ENSMUST00000163370.2 ENSMUST00000163370.3 ENSMUST00000163370.4 ENSMUST00000163370.5 ENSMUST00000163370.6 ENSMUST00000163370.7 G3UWG2 G3UWG2_MOUSE NM_001426933 Tiam1 uc007zvv.1 uc007zvv.2 uc007zvv.3 cardiac muscle hypertrophy guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity nucleus cytoplasm cytosol microtubule plasma membrane cell-cell junction apoptotic process cell-matrix adhesion signal transduction microtubule binding positive regulation of cell proliferation regulation of epithelial to mesenchymal transition positive regulation of neuron projection development postsynaptic density cell migration Rac protein signal transduction Ras GTPase binding kinase binding positive regulation of cell migration Rac guanyl-nucleotide exchange factor activity receptor tyrosine kinase binding extrinsic component of cytoplasmic side of plasma membrane positive regulation of protein binding ruffle membrane cellular macromolecular complex assembly regulation of Rho protein signal transduction intracellular signal transduction somatodendritic compartment response to cocaine neuronal cell body dendritic spine positive regulation of JUN kinase activity cell-cell contact zone axonal growth cone main axon synapse Rac GTPase binding positive regulation of axonogenesis positive regulation of dendritic spine morphogenesis regulation of insulin secretion involved in cellular response to glucose stimulus regulation of ERK1 and ERK2 cascade protein localization to membrane activation of GTPase activity glutamatergic synapse NMDA selective glutamate receptor signaling pathway positive regulation of Schwann cell chemotaxis regulation of modification of postsynaptic actin cytoskeleton neuron projection extension uc007zvv.1 uc007zvv.2 uc007zvv.3 
ENSMUST00000163377.10 Pym1 ENSMUST00000163377.10 PYM homolog 1, exon junction complex associated factor, transcript variant 1 (from RefSeq NM_030100.4) ENSMUST00000163377.1 ENSMUST00000163377.2 ENSMUST00000163377.3 ENSMUST00000163377.4 ENSMUST00000163377.5 ENSMUST00000163377.6 ENSMUST00000163377.7 ENSMUST00000163377.8 ENSMUST00000163377.9 NM_030100 PYM1_MOUSE Pym Pym1 Q80YD2 Q8CHP5 Wibg uc007hod.1 uc007hod.2 uc007hod.3 uc007hod.4 uc007hod.5 Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon- exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity). Interacts (via N-terminus) with MAGOH and RBM8A; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex (By similarity). Cytoplasm Nucleus, nucleolus Nucleus, nucleoplasm Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by XPO1/CRM1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CHP5-1; Sequence=Displayed; Name=2; IsoId=Q8CHP5-2; Sequence=VSP_025431; The eIF2A-like region shares sequence similarity with eIF2A and mediates the interaction with the 40S ribosomal subunit and the 48S preinitiation complex. Belongs to the pym family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay RNA binding nucleus nucleoplasm nucleolus cytoplasm cytosol regulation of translation cell junction exon-exon junction complex ribosome binding positive regulation of translation exon-exon junction complex disassembly uc007hod.1 uc007hod.2 uc007hod.3 uc007hod.4 uc007hod.5 
ENSMUST00000163392.3 Cep15 ENSMUST00000163392.3 centrosomal protein 15, transcript variant 2 (from RefSeq NM_178141.3) CEP15_MOUSE Cep15 ENSMUST00000163392.1 ENSMUST00000163392.2 NM_178141 Q6PFA6 Q8BGD0 Q8R061 uc007sfp.1 uc007sfp.2 uc007sfp.3 uc007sfp.4 May play a role in ciliary assembly. Cell projection, cilium Note=Locates at ciliary distal appendages. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGD0-1; Sequence=Displayed; Name=2; IsoId=Q8BGD0-2; Sequence=VSP_014596; molecular_function cellular_component biological_process uc007sfp.1 uc007sfp.2 uc007sfp.3 uc007sfp.4 
ENSMUST00000163394.3 Pnldc1 ENSMUST00000163394.3 poly(A)-specific ribonuclease (PARN)-like domain containing 1 (from RefSeq NM_001034866.1) B2RXZ1 ENSMUST00000163394.1 ENSMUST00000163394.2 NM_001034866 PNDC1_MOUSE Pnldc1 uc012akg.1 uc012akg.2 uc012akg.3 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells (PubMed:27515512). Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs (By similarity). Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Endoplasmic reticulum membrane ; Single-pass membrane protein Note=Localizes mainly in the endoplasmic reticulum. Specifically expressed in embryonic stem cells (PubMed:27515512). Highly expressed in testis (PubMed:26919431, PubMed:27515512). Expressed during early embryo development and fades during differentiation. Down-regulated in differentiated cells, due to methylation of its promoter by the methyltransferase DNMT3B. Belongs to the CAF1 family. Preliminary results in vitro suggested that Pnldc1 might act as an exonuclease that specifically cleaves precursor piRNAs (pre- piRNAs) at their 3' ends (PubMed:26919431). These results however require additional experimental evidences: another report showed that the protein mainly localizes to the endoplasmic reticulum and preferentially acts on poly(A) tails (PubMed:27515512). 3'-5'-exoribonuclease activity nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA poly(A) tail shortening blastocyst formation nucleic acid binding RNA binding nuclease activity exonuclease activity poly(A)-specific ribonuclease activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane hydrolase activity metal ion binding nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic uc012akg.1 uc012akg.2 uc012akg.3 
ENSMUST00000163396.3 Sox21os1 ENSMUST00000163396.3 SRY (sex determining region Y)-box 21, opposite strand 1, transcript variant 2 (from RefSeq NR_131969.1) ENSMUST00000163396.1 ENSMUST00000163396.2 NR_131969 uc057bfo.1 uc057bfo.2 uc057bfo.3 uc057bfo.4 uc057bfo.1 uc057bfo.2 uc057bfo.3 uc057bfo.4 
ENSMUST00000163401.9 Rfx7 ENSMUST00000163401.9 regulatory factor X, 7 (from RefSeq NM_001033536.1) ENSMUST00000163401.1 ENSMUST00000163401.2 ENSMUST00000163401.3 ENSMUST00000163401.4 ENSMUST00000163401.5 ENSMUST00000163401.6 ENSMUST00000163401.7 ENSMUST00000163401.8 F8VPJ6 NM_001033536 RFX7_MOUSE Rfx7 uc009qqb.1 uc009qqb.2 uc009qqb.3 Transcription factor (PubMed:29967452). Acts as a transcriptional activator by binding to promoter regions of target genes, such as Rec8, Mxd4 and Ddit4 (PubMed:29967452). Plays a role in natural killer (NK) cell maintenance and immunity (PubMed:29967452). May play a role in the process of ciliogenesis in the neural tube and neural tube closure (By similarity). Interacts (via PxLPxI/L motif) with RFXANK (via ankyrin repeats) (By similarity). Interacts (via PxLPxI/L motif) with ANKRA2 (via ankyrin repeats) (By similarity). Nucleus Expressed in spleen and lymph node and to a lower extend in brain (at protein level) (PubMed:29967452). Expressed in lymphoid organs and lymphoid cell subsets (PubMed:29967452). Expressed throughout natural killer (NK) cell maturation (PubMed:29967452). Knockout mice exhibit embryonic lethality with a frequency of 7% instead of the expected 25% pups being born from heterozygous parents, revealing a role in development (PubMed:29967452). Natural killer (NK) lymphocytes exhibit increased size, granularity, proliferation and energetic state (PubMed:29967452). Altered gene expression of genes linked to cell metabolism in NK cells (PubMed:29967452). Belongs to the RFX family. RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter uc009qqb.1 uc009qqb.2 uc009qqb.3 
ENSMUST00000163402.8 Synj2bp ENSMUST00000163402.8 synaptojanin 2 binding protein, transcript variant 1 (from RefSeq NM_025292.7) Arip2 ENSMUST00000163402.1 ENSMUST00000163402.2 ENSMUST00000163402.3 ENSMUST00000163402.4 ENSMUST00000163402.5 ENSMUST00000163402.6 ENSMUST00000163402.7 NM_025292 Omp25 Q2TTN6 Q6YNE6 Q78HT9 Q8K4F3 Q9D6K5 Q9D8G4 SYJ2B_MOUSE Synj2bp uc007och.1 uc007och.2 uc007och.3 uc007och.4 uc007och.5 Isoform 1 regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. Isoform 2 and isoform 3 show a stimulatory affect on activin-induced signal transduction and enhance activin type 2 expression at the cell surface. Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus) (By similarity). Interacts (via C- terminus) with RALBP1. Interacts (via PDZ domain) with ACVR2A (via C- terminus) and ACVR2B (via C-terminus). Forms a ternary complex with ACVR2A and RALBP1 (PubMed:11882656, PubMed:16648306). Interacts with MAPK12 (By similarity). Interacts with DLL1; enhances DLL1 protein stability, and promotes notch signaling in endothelial cells (By similarity). Q9D6K5; A2ARV4: Lrp2; NbExp=2; IntAct=EBI-300910, EBI-300875; Mitochondrion outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side Cytoplasm, perinuclear region Event=Alternative splicing; Named isoforms=4; Name=1 ; IsoId=Q9D6K5-1; Sequence=Displayed; Name=2 ; IsoId=Q9D6K5-2; Sequence=VSP_053102, VSP_053104; Name=3 ; IsoId=Q9D6K5-3; Sequence=VSP_053101, VSP_053102, VSP_053104; Name=4 ; IsoId=Q9D6K5-4; Sequence=VSP_053103; Isoform 1 and isoform 2 are widely expressed, notably in brain, heart, lung, liver, kidney, skeletal muscle, ovary and testis. Isoform 3 is detected only in heart, spleen and testis. Up-regulated between 12 and 24 hours after treatment with activin A and lipopolysaccharide (LPS). Down-regulated by calcium ionophore A23187. Sequence=AAH27433.2; Type=Erroneous initiation; Evidence=; negative regulation of endothelial cell proliferation positive regulation of receptor internalization protein binding cytoplasm mitochondrion mitochondrial outer membrane protein targeting endocytosis cytoplasm organization Rho protein signal transduction chemical synaptic transmission protein C-terminus binding regulation of Notch signaling pathway cell surface negative regulation of endothelial cell migration membrane integral component of membrane basolateral plasma membrane negative regulation of angiogenesis cell junction regulation of endocytosis integral component of mitochondrial outer membrane neuromuscular junction negative regulation of activin receptor signaling pathway positive regulation of activin receptor signaling pathway ionotropic glutamate receptor binding neuron projection receptor clustering establishment or maintenance of epithelial cell apical/basal polarity intracellular distribution of mitochondria perinuclear region of cytoplasm negative regulation of ERK1 and ERK2 cascade type II activin receptor binding receptor localization to synapse cell-cell adhesion postsynaptic density membrane negative regulation of sprouting angiogenesis positive regulation of protein localization to cell surface ionotropic glutamate receptor complex regulation of receptor internalization uc007och.1 uc007och.2 uc007och.3 uc007och.4 uc007och.5 
ENSMUST00000163439.3 Kplce ENSMUST00000163439.3 KPRP N-terminal and LCE C-terminal like protein (from RefSeq NM_025621.2) 2310050C09Rik ENSMUST00000163439.1 ENSMUST00000163439.2 G5E8Z3 G5E8Z3_MOUSE Kplce NM_025621 uc008qeu.1 uc008qeu.2 uc008qeu.3 uc008qeu.4 uc008qeu.1 uc008qeu.2 uc008qeu.3 uc008qeu.4 
ENSMUST00000163452.7 Repin1 ENSMUST00000163452.7 replication initiator 1, transcript variant 5 (from RefSeq NM_175099.3) ENSMUST00000163452.1 ENSMUST00000163452.2 ENSMUST00000163452.3 ENSMUST00000163452.4 ENSMUST00000163452.5 ENSMUST00000163452.6 NM_175099 Q5U4E2 Q8BTQ5 REPI1_MOUSE Zfp464 uc009buz.1 uc009buz.2 uc009buz.3 Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'- ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending (By similarity). Homodimers and homomultimers. Found in a complex with RIP60 and RIP100 (By similarity). Nucleus Sequence=BAC40716.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding nucleus lipid particle cytosol DNA replication cytosolic ribosome nuclear membrane positive regulation of glucose import metal ion binding regulation of fatty acid transport uc009buz.1 uc009buz.2 uc009buz.3 
ENSMUST00000163461.2 Vmn1r103 ENSMUST00000163461.2 vomeronasal 1 receptor 103 (from RefSeq NM_001166737.1) ENSMUST00000163461.1 K7N6X7 K7N6X7_MOUSE NM_001166737 Vmn1r103 uc012fca.1 uc012fca.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fca.1 uc012fca.2 
ENSMUST00000163475.3 2610021A01Rik ENSMUST00000163475.3 Nucleus (from UniProt E9Q0Q3) 2610021A01Rik AK011498 E9Q0Q3 E9Q0Q3_MOUSE ENSMUST00000163475.1 ENSMUST00000163475.2 uc009gls.1 uc009gls.2 uc009gls.3 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009gls.1 uc009gls.2 uc009gls.3 
ENSMUST00000163483.2 Rab1a ENSMUST00000163483.2 RAB1A, member RAS oncogene family (from RefSeq NM_008996.4) ENSMUST00000163483.1 NM_008996 Q0PD67 Q0PD67_MOUSE Rab1 Rab1A Rab1a uc007icv.1 uc007icv.2 Melanosome Belongs to the small GTPase superfamily. Rab family. autophagosome assembly Golgi membrane GTPase activity GTP binding cell cytoplasm ER to Golgi vesicle-mediated transport endocytosis autophagy Golgi organization membrane cell migration virion assembly growth hormone secretion defense response to bacterium vesicle transport along microtubule interleukin-8 secretion cargo loading into COPII-coated vesicle positive regulation of glycoprotein metabolic process uc007icv.1 uc007icv.2 
ENSMUST00000163507.8 Pfkm ENSMUST00000163507.8 phosphofructokinase, muscle, transcript variant 3 (from RefSeq NM_001163488.1) C8CMN5 C8CMN6 C8CMN7 ENSMUST00000163507.1 ENSMUST00000163507.2 ENSMUST00000163507.3 ENSMUST00000163507.4 ENSMUST00000163507.5 ENSMUST00000163507.6 ENSMUST00000163507.7 NM_001163488 O35513 P47857 PFKAM_MOUSE Pfk-m Pfka Q543L1 Q9JK94 uc011zyq.1 uc011zyq.2 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6- bisphosphate + H(+); Xref=Rhea:RHEA:16109, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:32966, ChEBI:CHEBI:57634, ChEBI:CHEBI:456216; EC=2.7.1.11; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 3/4. Homo- and heterotetramers (By similarity). Phosphofructokinase (PFK) enzyme functions as a tetramer composed of different combinations of 3 types of subunits, called PFKM (M), PFKL (L) and PFKP (P). The composition of the PFK tetramer differs according to the tissue type it is present in. The kinetic and regulatory properties of the tetrameric enzyme are dependent on the subunit composition, hence can vary across tissues (Probable). Isoform 2 and isoform 3 interact (via N-terminal testis-specific region) with GSTM5. Isoform 2 and isoform 3 interact (via C-terminus) with HK1 (via N-terminal spermatogenic cell-specific region). Cytoplasm [Isoform 2]: Cell projection, cilium, flagellum Note=Principal piece region of the sperm flagellum. [Isoform 3]: Cell projection, cilium, flagellum Note=Principal piece region of the sperm flagellum. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P47857-1; Sequence=Displayed; Name=2; Synonyms=Pfkms_V4 ; IsoId=P47857-2; Sequence=VSP_057079; Name=3; Synonyms=Pfkms_V3 ; IsoId=P47857-3; Sequence=VSP_057080; Isoform 1 is expressed in skeletal muscle (at protein level). Isoform 2 and isoform 3 are testis-specific and are detected in quiescent sperm (at protein level). They are first detected in the cytoplasm of round spermatids and subsequently in the flagellum of elongated spermatids extending into the seminiferous tubule lumen (at protein level). Isoform 2 is expressed at higher level than isoform 3 in testis. Isoform 2 and isoform 3 are first seen on postnatal day 16 corresponding to the age when midpachytene spermatocytes are present in the synchronous first wave of spermatogenesis. Isoform 2 and isoform 3 levels increase substantially between days 14 and 18 and continue to increase to age 30 days of neonatal testis development. GlcNAcylation decreases enzyme activity. Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. Sequence=AK138788; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; nucleotide binding catalytic activity 6-phosphofructokinase activity protein binding ATP binding nucleus cytoplasm cytosol cilium 6-phosphofructokinase complex glycogen catabolic process fructose 6-phosphate metabolic process glucose catabolic process glycolytic process protein C-terminus binding metabolic process phosphofructokinase activity membrane AMP binding kinase activity phosphorylation apical plasma membrane transferase activity kinase binding carbohydrate binding fructose 1,6-bisphosphate metabolic process motile cilium positive regulation of insulin secretion glucose homeostasis identical protein binding protein homodimerization activity cell projection positive regulation of transcription from RNA polymerase II promoter muscle cell cellular homeostasis carbohydrate phosphorylation metal ion binding monosaccharide binding protein oligomerization protein homotetramerization glycolytic process through fructose-6-phosphate canonical glycolysis fructose binding fructose-6-phosphate binding glycolysis from storage polysaccharide through glucose-1-phosphate sperm principal piece uc011zyq.1 uc011zyq.2 
ENSMUST00000163528.8 Brox ENSMUST00000163528.8 BRO1 domain and CAAX motif containing, transcript variant 2 (from RefSeq NM_001357242.2) BROX_MOUSE Brox ENSMUST00000163528.1 ENSMUST00000163528.2 ENSMUST00000163528.3 ENSMUST00000163528.4 ENSMUST00000163528.5 ENSMUST00000163528.6 ENSMUST00000163528.7 NM_001357242 Q8BWM8 Q8K2Q7 Q9DCT7 uc008ics.1 uc008ics.2 uc008ics.3 Nuclear envelope-associated factor that is involved in the nuclear envelope ruptures during interphase (NERDI) repair, where it is locally recruited by CHMP5 and reduces cytoskeletal stress through its action on SYN2 to help reseal the ruptured membrane. Monomer. Interacts with CHMP4B. Interacts with CHMP5: this interaction allows the recruitment of BROX to cellular membranes. Interacts with SYN2; this interaction promotes SYN2 ubiquitination and facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site. Nucleus membrane ; Lipid-anchor Note=During nuclear envelope repair, localizes at rupture sites where it is recruited by the CHMP7/ESCRT-III axis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K2Q7-1; Sequence=Displayed; Name=2; IsoId=Q8K2Q7-2; Sequence=VSP_028041, VSP_028042; Farnesylation is required for nuclear envelope localization. Belongs to the BROX family. molecular_function biological_process membrane uc008ics.1 uc008ics.2 uc008ics.3 
ENSMUST00000163544.2 Speer1i ENSMUST00000163544.2 Speer1i (from geneSymbol) ENSMUST00000163544.1 F7AXK2 F7AXK2_MOUSE Gm8871 uc290tcx.1 uc290tcx.2 uc290tcx.1 uc290tcx.2 
ENSMUST00000163558.3 Ndufaf2 ENSMUST00000163558.3 NADH:ubiquinone oxidoreductase complex assembly factor 2, transcript variant 2 (from RefSeq NM_001360140.2) ENSMUST00000163558.1 ENSMUST00000163558.2 NDUF2_MOUSE NM_001360140 Ndufa12l Q14A56 Q59J78 Q80VX9 uc007ruu.1 uc007ruu.2 uc007ruu.3 uc007ruu.4 Acts as a molecular chaperone for mitochondrial complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Mitochondrion Belongs to the complex I NDUFA12 subunit family. Sequence=AAP33449.1; Type=Frameshift; Evidence=; mitochondrion NADH dehydrogenase (ubiquinone) activity electron carrier activity membrane respiratory electron transport chain cellular respiration negative regulation of insulin secretion involved in cellular response to glucose stimulus reactive oxygen species metabolic process uc007ruu.1 uc007ruu.2 uc007ruu.3 uc007ruu.4 
ENSMUST00000163559.8 Ccr9 ENSMUST00000163559.8 Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. (from UniProt Q9WUT7) A2RSM5 AK019478 CCR9_MOUSE Cmkbr10 ENSMUST00000163559.1 ENSMUST00000163559.2 ENSMUST00000163559.3 ENSMUST00000163559.4 ENSMUST00000163559.5 ENSMUST00000163559.6 ENSMUST00000163559.7 Q543I4 Q9WUT7 uc009sgl.1 uc009sgl.2 uc009sgl.3 uc009sgl.4 Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Cell membrane ; Multi-pass membrane protein Highly expressed in the thymus and low in lymph nodes and spleen. Belongs to the G-protein coupled receptor 1 family. CD8-positive, gamma-delta intraepithelial T cell differentiation G-protein coupled receptor activity chemokine receptor activity protein binding plasma membrane chemotaxis immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration external side of plasma membrane cell surface membrane integral component of membrane C-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding cell chemotaxis chemokine-mediated signaling pathway uc009sgl.1 uc009sgl.2 uc009sgl.3 uc009sgl.4 
ENSMUST00000163568.4 Six2 ENSMUST00000163568.4 sine oculis-related homeobox 2 (from RefSeq NM_011380.2) ENSMUST00000163568.1 ENSMUST00000163568.2 ENSMUST00000163568.3 NM_011380 P70179 Q62232 SIX2_MOUSE uc008duc.1 uc008duc.2 uc008duc.3 uc008duc.4 Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation (PubMed:20515681). During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1 (PubMed:19660448). During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway (PubMed:18321982). May also be involved in limb tendon and ligament development (PubMed:7720577). Plays a role in cell proliferation and migration (By similarity). Interacts with TCF7L2; in a canonical Wnt signaling independent manner; prevents transcription of differentiation genes in cap mesenchyme. Interacts with OSR1; form a strong repressor complex with TCF7L2, TLE2 and TLE3 to prevent the activation of Wnt/beta- catenin target genes in the cap mesenchyme. Interacts with HOXA11, EYA1 and EYA3. Q62232; P97767: Eya1; NbExp=3; IntAct=EBI-1368736, EBI-1368503; Nucleus Expressed in phalangeal tendons, in smooth muscle and in head and body mesenchyme. First expressed at 8.5 dpc of embryo development in a restricted mesodermal subpopulation at the anterior hindbrain level. Expression of SIX2 in the developing limb begins at 11 dpc and is more pronounced ventrally. It progresses into the developing phalanges at 12.5 dpc. At 10.5 dpc expressed in the metanephric blastema, which signals the ureteric bud to evaginate from the Wolffian duct. At 11.5 dpc expressed at high levels in the dorsal anephric mesenchyme and is down-regulated where pretubular aggregates will form on the ventral side of the ureteric bud. At 14.5 dpc, expression persists in the peripheral mesenchyme of the renal cortex. At 9.5 dpc, expressed in the splanchnic mesoderm of the stomach anlage. By 10.5 dpc, expressed in the mesoderm of the posterior stomach. Expression is seen in the presumptive glandular stomach primordium at 11.5 dpc. At 12.5 dpc, becomes restricted to the mesenchyme of the antral region of the posterior stomach. At 14.5 dpc, expression remains in the antrum, just anterior to the pyloric sphincter. Down-regulated by CTNNB1 upon differentiation. Activated by TLX1 in the kidney and repressed by HOXA2 in the branchial arch and facial mesenchyme. Six2 knockout heterozygous mice not exhibit any obvious abnormalities. However, Six2 knockout nullizygous mice die soon after birth. Belongs to the SIX/Sine oculis homeobox family. Sequence=CAA56584.1; Type=Erroneous initiation; Evidence=; transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding metanephros development kidney development chondrocyte differentiation mesenchymal to epithelial transition involved in metanephros morphogenesis DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated protein import into nucleus multicellular organism development mesodermal cell fate specification transcription factor binding cell proliferation anterior/posterior axis specification cell migration regulation of ossification regulation of chondrocyte differentiation middle ear morphogenesis sequence-specific DNA binding macromolecular complex binding negative regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic digestive tract morphogenesis embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis anatomical structure development nephron development nephron morphogenesis mesenchymal stem cell maintenance involved in nephron morphogenesis condensed mesenchymal cell proliferation mesenchymal cell differentiation involved in kidney development regulation of branching involved in ureteric bud morphogenesis mesenchymal stem cell proliferation positive regulation of chondrocyte proliferation uc008duc.1 uc008duc.2 uc008duc.3 uc008duc.4 
ENSMUST00000163571.8 Pick1 ENSMUST00000163571.8 protein interacting with C kinase 1, transcript variant 1 (from RefSeq NM_008837.3) E9PUZ5 E9PUZ5_MOUSE ENSMUST00000163571.1 ENSMUST00000163571.2 ENSMUST00000163571.3 ENSMUST00000163571.4 ENSMUST00000163571.5 ENSMUST00000163571.6 ENSMUST00000163571.7 NM_008837 Pick1 uc007wsy.1 uc007wsy.2 uc007wsy.3 uc007wsy.4 Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. Cytoplasm, cytoskeleton Cytoplasm, perinuclear region Membrane ; Lipid-anchor Synapse, synaptosome cytoplasm mitochondrion cytosol plasma membrane protein kinase C-activating G-protein coupled receptor signaling pathway protein C-terminus binding monoamine transport aggresome enzyme binding protein domain specific binding presynaptic membrane uc007wsy.1 uc007wsy.2 uc007wsy.3 uc007wsy.4 
ENSMUST00000163578.8 T2 ENSMUST00000163578.8 brachyury 2 (from RefSeq NM_001161832.1) A0A338P791 A0A338P791_MOUSE ENSMUST00000163578.1 ENSMUST00000163578.2 ENSMUST00000163578.3 ENSMUST00000163578.4 ENSMUST00000163578.5 ENSMUST00000163578.6 ENSMUST00000163578.7 NM_001161832 T2 uc012ajs.1 uc012ajs.2 uc012ajs.3 molecular_function cellular_component notochord formation uc012ajs.1 uc012ajs.2 uc012ajs.3 
ENSMUST00000163584.8 Tceal8 ENSMUST00000163584.8 transcription elongation factor A (SII)-like 8, transcript variant 2 (from RefSeq NM_025703.3) A2AJR7 ENSMUST00000163584.1 ENSMUST00000163584.2 ENSMUST00000163584.3 ENSMUST00000163584.4 ENSMUST00000163584.5 ENSMUST00000163584.6 ENSMUST00000163584.7 NM_025703 Q9CYP9 Q9CZY2 TCAL8_MOUSE uc012hou.1 uc012hou.2 May be involved in transcriptional regulation. Nucleus Belongs to the TFS-II family. TFA subfamily. nucleus WW domain binding uc012hou.1 uc012hou.2 
ENSMUST00000163590.9 Dtwd2 ENSMUST00000163590.9 DTW domain containing 2, transcript variant 1 (from RefSeq NM_026854.3) DTWD2_MOUSE Dtwd2 ENSMUST00000163590.1 ENSMUST00000163590.2 ENSMUST00000163590.3 ENSMUST00000163590.4 ENSMUST00000163590.5 ENSMUST00000163590.6 ENSMUST00000163590.7 ENSMUST00000163590.8 NM_026854 Q9D0U1 uc012bcw.1 uc012bcw.2 uc012bcw.3 Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)). Reaction=a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3- amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'- thioadenosine; Xref=Rhea:RHEA:62432, Rhea:RHEA-COMP:13339, Rhea:RHEA- COMP:16092, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789, ChEBI:CHEBI:65315, ChEBI:CHEBI:82930; EC=2.5.1.25; Evidence=; Nucleus Cytoplasm Belongs to the TDD superfamily. DTWD2 family. molecular_function cellular_component uc012bcw.1 uc012bcw.2 uc012bcw.3 
ENSMUST00000163595.3 Cdyl ENSMUST00000163595.3 chromodomain protein, Y chromosome-like, transcript variant 5 (from RefSeq NR_166191.1) CDYL_MOUSE Cdyl ENSMUST00000163595.1 ENSMUST00000163595.2 NR_166191 Q3U0W2 Q6P6N3 Q9WTK2 uc007qcg.1 uc007qcg.2 uc007qcg.3 uc007qcg.4 [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:12947414). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:12947414). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (By similarity). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (By similarity). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (PubMed:24144980). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (By similarity). Required for neuronal migration during brain development by repressing expression of RHOA (PubMed:28076783). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (PubMed:28842554). In addition to acting as a chromatin reader, acts as a hydro-lyase (By similarity). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)- butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (By similarity). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (PubMed:28803779). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (PubMed:30665597). May have histone acetyltransferase activity; such activity is however unsure in vivo (PubMed:12072557). [Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N- terminal extension that inactivates the chromo domain. Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; Reaction=3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O; Xref=Rhea:RHEA:45584, ChEBI:CHEBI:15377, ChEBI:CHEBI:57332, ChEBI:CHEBI:78611; Evidence=; Forms multimers and multimerization is required for stable binding to chromatin (By similarity). Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain (PubMed:12947414). Interacts with EZH2, EED, SUZ12, REST, EHMT1 and EHMT2 (By similarity). Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2 (By similarity). Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2 (By similarity). Interacts with CHAF1A and CHAF1B; bridging the CAF-1 complex to the MCM2-7 (MCM) complex (By similarity). Interacts with MCM3 and MCM5; bridging the CAF-1 complex to the MCM2-7 (MCM) complex (By similarity). Interacts with EHMT2 and PRDM9; interaction only takes place when PRDM9 is bound to hotspot DNA (PubMed:27932493). [Isoform 2]: Nucleus romosome te=Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin (PubMed:24144980). Multimerization is required for chromatin-binding (By similarity). Recruited to Xist RNA-coated X chromosome (PubMed:24144980). Recruited to sites of DNA double strand breaks in a PARP1-dependent fashion (PubMed:29177481). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=a , CDYL1a ; IsoId=Q9WTK2-1; Sequence=Displayed; Name=2; Synonyms=b , CDYL1b ; IsoId=Q9WTK2-2; Sequence=VSP_026385, VSP_026386; Highly expressed in testis (at protein level) (PubMed:10192397). Expressed in the hippocampus (at protein level) (PubMed:28842554). Expressed in the medial prefrontal cortex, prelimbic cortex, intralimbic cortex and cingulate cortex area (at protein level) (PubMed:30665597). Isoform 1: Expressed as 2 transcripts encoding the same protein, a ubiquitous transcript and a highly expressed testis- specific transcript (PubMed:10192397). Highly expressed in elongating spermatids during histone hyperacetylation. Down-regulated upon neuronal activity in the hippocampus (PubMed:28842554). Up-regulated after social defeat stress (PubMed:30665597). The chromo domain recognizes and binds histone H3K9me3, histone H3K27me2 and histone H3K27me3. The acetyl-CoA-binding domain mediates crotonyl-coA hydratase activity (By similarity). The acetyl-CoA-binding domain is required for recruitment to sites of DNA double strand breaks and for binding to poly (ADP ribose) moieties (By similarity). Mice show no overt differences in body weight, but males display a substantial decrease in the size and weight of the testis and show reduced fertility. Males show decreased epididymal sperm counts, sperm cell motility, and sperm velocity and a marked increase in cell apoptosis in the testis. Interaction with HDAC1 or HDAC2 prevents coenzyme A binding. Was initially reported to display histone acetyltransferase activity, with a preference for histone H4 (PubMed:12072557). Such activity is however unsure in vivo. Histone acetyltransferase activity would be in contradiction with the function of the protein in corepressor complexes (PubMed:12947414). Moreover, crystallographic studies in human demonstrated that it does not share any similarity with other acetyltransferases and instead forms a crotonase-like fold. chromatin binding transcription corepressor activity catalytic activity histone acetyltransferase activity protein binding nucleus chromosome cytoplasm spermatogenesis spermatid development histone acetylation nuclear speck transferase activity transferase activity, transferring acyl groups lyase activity cell differentiation protein binding, bridging methylated histone binding random inactivation of X chromosome negative regulation of nucleic acid-templated transcription uc007qcg.1 uc007qcg.2 uc007qcg.3 uc007qcg.4 
ENSMUST00000163607.2 Vmn2r21 ENSMUST00000163607.2 vomeronasal 2, receptor 21 (from RefSeq NM_001104635.1) ENSMUST00000163607.1 K7N6Y7 K7N6Y7_MOUSE NM_001104635 Vmn2r21 uc009vdw.1 uc009vdw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vdw.1 uc009vdw.2 
ENSMUST00000163624.8 Iqch ENSMUST00000163624.8 Iqch (from geneSymbol) AK019535 B7ZNG8 B7ZNG8_MOUSE ENSMUST00000163624.1 ENSMUST00000163624.2 ENSMUST00000163624.3 ENSMUST00000163624.4 ENSMUST00000163624.5 ENSMUST00000163624.6 ENSMUST00000163624.7 Iqch uc012gux.1 uc012gux.2 uc012gux.3 uc012gux.4 uc012gux.5 uc012gux.1 uc012gux.2 uc012gux.3 uc012gux.4 uc012gux.5 
ENSMUST00000163643.3 Eps15l1 ENSMUST00000163643.3 epidermal growth factor receptor pathway substrate 15-like 1, transcript variant 1 (from RefSeq NM_007944.3) ENSMUST00000163643.1 ENSMUST00000163643.2 EP15R_MOUSE Eps15-rs Eps15R NM_007944 Q3U7L9 Q3UIS9 Q60902 Q8CB60 Q8CB70 Q91WH8 uc009mfr.1 uc009mfr.2 uc009mfr.3 uc009mfr.4 uc009mfr.5 uc009mfr.6 Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 (By similarity). Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2). Interacts with FCHO1 (By similarity). Interacts with FCHO2. Interacts (via EH domains) with DAB2. Interacts with UBQLN1 (via ubiquitin-like domain). Interacts with CAVIN3 (via leucine-zipper domain) (By similarity). Interacts with REPS2 (By similarity). Q60902; P98078: Dab2; NbExp=2; IntAct=EBI-443931, EBI-1391846; Q60902; P42567: Eps15; NbExp=2; IntAct=EBI-443931, EBI-443923; Cell membrane ; Peripheral membrane protein Nucleus Membrane, coated pit Note=Localized to plasma membrane coated pits. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q60902-1; Sequence=Displayed; Name=2; IsoId=Q60902-2; Sequence=VSP_010683, VSP_010684; Name=3; IsoId=Q60902-3; Sequence=VSP_010681, VSP_010682; Name=4; IsoId=Q60902-4; Sequence=VSP_022638, VSP_022639; Phosphorylated on tyrosine residues by EGFR. calcium ion binding protein binding nucleus plasma membrane clathrin-coated pit endocytosis membrane clathrin coat of coated pit metal ion binding uc009mfr.1 uc009mfr.2 uc009mfr.3 uc009mfr.4 uc009mfr.5 uc009mfr.6 
ENSMUST00000163651.2 H2al2c ENSMUST00000163651.2 H2A histone family member L2C (from RefSeq NM_001177569.1) A9Z055 A9Z055_MOUSE ENSMUST00000163651.1 H2al2b H2al2c NM_001177569 uc012hru.1 uc012hru.2 The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc012hru.1 uc012hru.2 
ENSMUST00000163655.3 Gm8127 ENSMUST00000163655.3 predicted gene 8127 (from RefSeq NM_001378715.1) E9PWR6 E9Q0P0 E9Q0P0_MOUSE ENSMUST00000163655.1 ENSMUST00000163655.2 Gm8094 Gm8127 NM_001378715 uc288sro.1 uc288sro.2 molecular_function cellular_component biological_process uc288sro.1 uc288sro.2 
ENSMUST00000163659.3 Nxnl1 ENSMUST00000163659.3 nucleoredoxin-like 1 (from RefSeq NM_145598.3) ENSMUST00000163659.1 ENSMUST00000163659.2 NM_145598 NXNL1_MOUSE Q8VC33 Q91W38 Rdcvf Txnl6 uc012gfu.1 uc012gfu.2 uc012gfu.3 Plays an important role in retinal cone photoreceptor survival (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (PubMed:15220920). Interacts with isoform 1 of BSG. Cell projection, cilium, photoreceptor outer segment Expressed in the retina (at protein level) (PubMed:15220920, PubMed:19843539). Expressed predominantly by photoreceptors in both the inner and outer nuclear layer (at protein level) (PubMed:15220920, PubMed:19843539). Not expressed in the testis, spleen, intestine, lung, cerebellum, or kidney (PubMed:15220920). Belongs to the nucleoredoxin family. photoreceptor outer segment mitochondrion cell projection photoreceptor cell maintenance uc012gfu.1 uc012gfu.2 uc012gfu.3 
ENSMUST00000163666.3 Eif4a1 ENSMUST00000163666.3 eukaryotic translation initiation factor 4A1, transcript variant 1 (from RefSeq NM_144958.4) ENSMUST00000163666.1 ENSMUST00000163666.2 Eif4a1 NM_144958 Q5F2A7 Q5F2A7_MOUSE uc007jra.1 uc007jra.2 uc007jra.3 uc007jra.4 ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. RNA helicase. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. Belongs to the DEAD box helicase family. eIF4A subfamily. nucleotide binding nucleic acid binding double-stranded RNA binding helicase activity ATP binding cytoplasm hydrolase activity uc007jra.1 uc007jra.2 uc007jra.3 uc007jra.4 
ENSMUST00000163690.3 C030017D09Rik ENSMUST00000163690.3 C030017D09Rik (from geneSymbol) AK047727 ENSMUST00000163690.1 ENSMUST00000163690.2 uc007rkm.1 uc007rkm.2 uc007rkm.3 uc007rkm.1 uc007rkm.2 uc007rkm.3 
ENSMUST00000163705.3 Mfsd4b1 ENSMUST00000163705.3 major facilitator superfamily domain containing 4B1 (from RefSeq NM_144821.4) ENSMUST00000163705.1 ENSMUST00000163705.2 MF4B1_MOUSE Mfsd4b1 NM_144821 Naglt1a Q8VCV9 uc007ewl.1 uc007ewl.2 uc007ewl.3 uc007ewl.4 May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney. Apical cell membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. Sequence=AAH18406.1; Type=Erroneous initiation; Evidence=; Sequence=BAC41015.1; Type=Erroneous initiation; Evidence=; glucose transmembrane transporter activity cellular_component plasma membrane integral component of plasma membrane ion transport sodium ion transport carbohydrate transport symporter activity membrane integral component of membrane apical plasma membrane transmembrane transport glucose transmembrane transport uc007ewl.1 uc007ewl.2 uc007ewl.3 uc007ewl.4 
ENSMUST00000163707.2 Gm17189 ENSMUST00000163707.2 Gm17189 (from geneSymbol) AK014121 ENSMUST00000163707.1 uc288yrh.1 uc288yrh.2 uc288yrh.1 uc288yrh.2 
ENSMUST00000163710.8 Tnnt1 ENSMUST00000163710.8 troponin T1, skeletal, slow, transcript variant 4 (from RefSeq NM_001360154.1) B7ZNV5 B7ZNV6 ENSMUST00000163710.1 ENSMUST00000163710.2 ENSMUST00000163710.3 ENSMUST00000163710.4 ENSMUST00000163710.5 ENSMUST00000163710.6 ENSMUST00000163710.7 NM_001360154 O88346 O88795 Q9QUP7 TNNT1_MOUSE uc012ewu.1 uc012ewu.2 uc012ewu.3 uc012ewu.4 This gene encodes the slow skeletal tropomyosin-binding subunit of the troponin complex and plays an essential role in the regulation of striated muscle contraction. In humans, mutations in this gene are associated with nemaline myopathy type 5. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]. Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Interacts with TPM3. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=High Mr-1; IsoId=O88346-1; Sequence=Displayed; Name=2; Synonyms=High Mr-2; IsoId=O88346-2; Sequence=VSP_013787; Name=3; Synonyms=Low Mr; IsoId=O88346-3; Sequence=VSP_013786; Expressed in adult soleus muscle. In masseter expression decreases during development and becomes undetectable 3 weeks after birth. [Isoform 1]: Major. [Isoform 2]: Major. [Isoform 3]: Minor. Belongs to the troponin T family. skeletal muscle contraction calcium ion binding tropomyosin binding troponin complex muscle contraction regulation of muscle contraction transition between fast and slow fiber troponin T binding slow-twitch skeletal muscle fiber contraction sarcomere organization negative regulation of muscle contraction cardiac muscle contraction calcium-dependent ATPase activity uc012ewu.1 uc012ewu.2 uc012ewu.3 uc012ewu.4 
ENSMUST00000163715.2 Gm17105 ENSMUST00000163715.2 Gm17105 (from geneSymbol) ENSMUST00000163715.1 KY467686 uc288rnv.1 uc288rnv.2 uc288rnv.1 uc288rnv.2 
ENSMUST00000163732.8 Mmel1 ENSMUST00000163732.8 membrane metallo-endopeptidase-like 1 (from RefSeq NM_013783.2) E9PVK7 E9PVK7_MOUSE ENSMUST00000163732.1 ENSMUST00000163732.2 ENSMUST00000163732.3 ENSMUST00000163732.4 ENSMUST00000163732.5 ENSMUST00000163732.6 ENSMUST00000163732.7 Mmel1 NM_013783 uc012dqm.1 uc012dqm.2 uc012dqm.3 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Membrane ; Single- pass type II membrane protein endopeptidase activity metalloendopeptidase activity extracellular space proteolysis metallopeptidase activity membrane integral component of membrane uc012dqm.1 uc012dqm.2 uc012dqm.3 
ENSMUST00000163753.8 Mgat4c ENSMUST00000163753.8 MGAT4 family, member C, transcript variant 1 (from RefSeq NM_001162368.1) ENSMUST00000163753.1 ENSMUST00000163753.2 ENSMUST00000163753.3 ENSMUST00000163753.4 ENSMUST00000163753.5 ENSMUST00000163753.6 ENSMUST00000163753.7 MGT4C_MOUSE NM_001162368 Q9D2X2 Q9D306 uc011xmt.1 uc011xmt.2 uc011xmt.3 Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity). Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc- (1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D- glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc- (1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]- beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl- [protein] + UDP; Xref=Rhea:RHEA:16057, Rhea:RHEA-COMP:13526, Rhea:RHEA-COMP:14374, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:60651, ChEBI:CHEBI:139507; EC=2.4.1.145; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 54 family. Golgi membrane Golgi apparatus protein glycosylation protein N-linked glycosylation acetylglucosaminyltransferase activity alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups metal ion binding uc011xmt.1 uc011xmt.2 uc011xmt.3 
ENSMUST00000163754.9 Xpnpep3 ENSMUST00000163754.9 X-prolyl aminopeptidase 3, mitochondrial, transcript variant 2 (from RefSeq NM_001347075.1) B7ZMP1 ENSMUST00000163754.1 ENSMUST00000163754.2 ENSMUST00000163754.3 ENSMUST00000163754.4 ENSMUST00000163754.5 ENSMUST00000163754.6 ENSMUST00000163754.7 ENSMUST00000163754.8 NM_001347075 Q8BHT9 XPP3_MOUSE uc011zwj.1 uc011zwj.2 uc011zwj.3 Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. Promotes TNFRSF1B- mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling. Reaction=Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.; EC=3.4.11.9; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; Homodimer. Interacts with TNFRSF1B/TNFR2 (activated) and TRAF2. Mitochondrion Cytoplasm Note=Mainly mitochondrial. Translocates to the cytoplasm following TNFRSF1B activation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B7ZMP1-1; Sequence=Displayed; Name=2; IsoId=B7ZMP1-2; Sequence=VSP_040145, VSP_040146; Expressed in brain, kidney, heart, liver, skeletal muscle and testis. Belongs to the peptidase M24B family. glomerular filtration aminopeptidase activity cytoplasm mitochondrion proteolysis protein processing hydrolase activity manganese ion binding protein homodimerization activity metal ion binding metalloaminopeptidase activity uc011zwj.1 uc011zwj.2 uc011zwj.3 
ENSMUST00000163762.8 Prr5l ENSMUST00000163762.8 proline rich 5 like, transcript variant 3 (from RefSeq NM_001110849.1) A2AVJ5 B7ZWM2 ENSMUST00000163762.1 ENSMUST00000163762.2 ENSMUST00000163762.3 ENSMUST00000163762.4 ENSMUST00000163762.5 ENSMUST00000163762.6 ENSMUST00000163762.7 NM_001110849 PRR5L_MOUSE Protor2 Q80Y78 Q8BIT0 uc012cad.1 uc012cad.2 Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (By similarity). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM- CSF, in response to stress. Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress. Interacts with the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with RFFL. Interacts (via C-terminus) with ZFP36 (via C- terminus); this interaction may accelerate ZFP36-mediated mRNA decay during stress. Interacts with RICTOR. Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid (By similarity). Belongs to the PROTOR family. Sequence=AAH48394.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC25324.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE26803.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of protein phosphorylation positive regulation of protein phosphorylation mitochondrion negative regulation of signal transduction regulation of fibroblast migration positive regulation of phosphatidylinositol 3-kinase signaling ubiquitin protein ligase binding TORC2 complex cellular response to oxidative stress TORC2 signaling positive regulation of mRNA catabolic process positive regulation of intracellular protein transport uc012cad.1 uc012cad.2 
ENSMUST00000163765.3 Nup155 ENSMUST00000163765.3 nucleoporin 155 (from RefSeq NM_133227.3) ENSMUST00000163765.1 ENSMUST00000163765.2 NM_133227 NU155_MOUSE Q99P88 uc007vej.1 uc007vej.2 uc007vej.3 uc007vej.4 Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. Interacts with GLE1 and NUP35/NUP53. Able to form a heterotrimer with GLE1 and NUP42 in vitro (By similarity). Forms a complex with NUP35, NUP93, NUP205 and lamin B (By similarity). Nucleus, nuclear pore complex Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side Note=In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis. Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity). Disulfide-linked to NUP62. The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC. Homozygous null mice die before embryonic day 8.5. Belongs to the non-repetitive/WGA-negative nucleoporin family. transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery nucleus nuclear envelope nuclear pore cytoplasm mRNA export from nucleus protein import into nucleus nucleocytoplasmic transport nuclear envelope organization protein transport membrane structural constituent of nuclear pore nuclear membrane protein targeting to nuclear inner membrane nuclear pore inner ring mRNA transport atrial cardiac muscle cell action potential uc007vej.1 uc007vej.2 uc007vej.3 uc007vej.4 
ENSMUST00000163766.8 Zscan29 ENSMUST00000163766.8 May be involved in transcriptional regulation. (from UniProt E9Q5B4) AK050477 E9Q5B4 E9Q5B4_MOUSE ENSMUST00000163766.1 ENSMUST00000163766.2 ENSMUST00000163766.3 ENSMUST00000163766.4 ENSMUST00000163766.5 ENSMUST00000163766.6 ENSMUST00000163766.7 Zscan29 uc289zvw.1 uc289zvw.2 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc289zvw.1 uc289zvw.2 
ENSMUST00000163779.8 Snca ENSMUST00000163779.8 synuclein, alpha, transcript variant 2 (from RefSeq NM_009221.2) ENSMUST00000163779.1 ENSMUST00000163779.2 ENSMUST00000163779.3 ENSMUST00000163779.4 ENSMUST00000163779.5 ENSMUST00000163779.6 ENSMUST00000163779.7 NM_009221 O55042 Q3U130 Q9CXF8 Q9EQC3 Q9QUR3 SYUA_MOUSE Syn uc009cdo.1 uc009cdo.2 uc009cdo.3 Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282, PubMed:25246573). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity). Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (By similarity). Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (PubMed:20798282, PubMed:25246573). Interacts with RPH3A and RAB3A (By similarity). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (By similarity). Interacts with SEPTIN4 (PubMed:17296554). O55042; P00520: Abl1; NbExp=2; IntAct=EBI-2310271, EBI-914519; O55042; P55258: Rab8a; NbExp=2; IntAct=EBI-2310271, EBI-398411; O55042; Q61327: Slc6a3; NbExp=5; IntAct=EBI-2310271, EBI-7839708; O55042; P08228: Sod1; NbExp=2; IntAct=EBI-2310271, EBI-1635090; O55042; Q69ZS6: Sv2c; NbExp=2; IntAct=EBI-2310271, EBI-36944762; Cytoplasm Membrane Nucleus Synapse Secreted Cell projection, axon Note=Membrane-bound in dopaminergic neurons (By similarity). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (PubMed:17296554). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O55042-1; Sequence=Displayed; Name=2; IsoId=O55042-2; Sequence=VSP_025018, VSP_025019; Expressed in brain (at protein level) (PubMed:31034892). Expressed in the striatum (at protein level) (PubMed:17296554). Highly expressed in presynaptic terminals in the central nervous system (PubMed:10707987). Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress. Ubiquitinated. The predominant conjugate is the diubiquitinated form. Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure. Snca-deficient mice are viable and fertile, possess intact brain architecture but exhibit decreased striatal dopamin content and amphetamine sensitivity (PubMed:10707987). Simultaneous knockout of SNCA, SNCB and SNCG exhibit an age-dependent decrease in SNARE-complex assembly. Thus, synucleins are required for maintaining normal SNARE-complex assembly during aging in mice (PubMed:20798282). Belongs to the synuclein family. SNARE binding magnesium ion binding microglial cell activation positive regulation of receptor recycling negative regulation of protein phosphorylation positive regulation of neurotransmitter secretion synaptic transmission, dopaminergic actin binding copper ion binding calcium ion binding protein binding phospholipid binding extracellular region extracellular space nucleus nuclear outer membrane cytoplasm mitochondrion mitochondrial outer membrane mitochondrial inner membrane mitochondrial intermembrane space mitochondrial matrix rough endoplasmic reticulum Golgi apparatus cytosol ribosome cytoskeleton plasma membrane cell cortex fatty acid metabolic process neutral lipid metabolic process phospholipid metabolic process apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrial membrane organization chemical synaptic transmission aging microtubule binding synaptic vesicle ferrous iron binding zinc ion binding adult locomotory behavior response to iron(II) ion regulation of phospholipase activity negative regulation of platelet-derived growth factor receptor signaling pathway regulation of glutamate secretion regulation of dopamine secretion actin cytoskeleton membrane synaptic vesicle exocytosis synaptic vesicle priming inclusion body oxidoreductase activity kinesin binding enzyme binding protein domain specific binding regulation of transmembrane transporter activity cell junction axon growth cone Hsp70 protein binding cytoplasmic vesicle membrane synaptic vesicle membrane platelet alpha granule membrane negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion negative regulation of transporter activity response to lipopolysaccharide negative regulation of monooxygenase activity macromolecular complex positive regulation of peptidyl-serine phosphorylation response to interferon-gamma cellular response to oxidative stress negative regulation of histone acetylation SNARE complex assembly regulation of locomotion response to cocaine histone binding dopamine biosynthetic process dopamine metabolic process response to drug mitochondrial ATP synthesis coupled electron transport identical protein binding alpha-tubulin binding neuronal cell body cysteine-type endopeptidase inhibitor activity involved in apoptotic process regulation of macrophage activation negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process terminal bouton intracellular membrane-bounded organelle phospholipase binding negative regulation of neuron apoptotic process axon terminus cellular response to fibroblast growth factor stimulus synapse positive regulation of endocytosis negative regulation of exocytosis positive regulation of exocytosis negative regulation of dopamine metabolic process metal ion binding regulation of neurotransmitter secretion protein N-terminus binding behavioral response to cocaine tau protein binding regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity perinuclear region of cytoplasm beta-tubulin binding synaptic vesicle endocytosis synaptic vesicle transport arachidonic acid binding positive regulation of inflammatory response positive regulation of synaptic transmission synapse organization regulation of acyl-CoA biosynthetic process phosphoprotein binding protein oligomerization protein tetramerization positive regulation of release of sequestered calcium ion into cytosol negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake regulation of norepinephrine uptake negative regulation of norepinephrine uptake oxidation-reduction process excitatory postsynaptic potential long-term synaptic potentiation positive regulation of inositol phosphate biosynthetic process membrane organization negative regulation of thrombin-activated receptor signaling pathway response to interleukin-1 dynein complex binding cellular response to copper ion positive regulation of protein serine/threonine kinase activity presynapse postsynapse supramolecular fiber regulation of neuron death negative regulation of neuron death positive regulation of neuron death cuprous ion binding positive regulation of glutathione peroxidase activity positive regulation of hydrogen peroxide catabolic process response to desipramine negative regulation of chaperone-mediated autophagy regulation of presynapse assembly regulation of reactive oxygen species metabolic process uc009cdo.1 uc009cdo.2 uc009cdo.3 
ENSMUST00000163781.3 9330020H09Rik ENSMUST00000163781.3 RIKEN cDNA 9330020H09 gene (from RefSeq NR_028442.1) ENSMUST00000163781.1 ENSMUST00000163781.2 NR_028442 uc007xmx.1 uc007xmx.2 uc007xmx.3 uc007xmx.4 uc007xmx.5 uc007xmx.1 uc007xmx.2 uc007xmx.3 uc007xmx.4 uc007xmx.5 
ENSMUST00000163785.2 Chrm1 ENSMUST00000163785.2 cholinergic receptor, muscarinic 1, CNS, transcript variant 1 (from RefSeq NM_001112697.1) ACM1_MOUSE Chrm-1 ENSMUST00000163785.1 NM_001112697 P12657 Q52KQ0 Q8BJN3 uc008gmg.1 uc008gmg.2 uc008gmg.3 uc008gmg.4 uc008gmg.5 The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Interacts with GPRASP2 (By similarity). Interacts with TMEM147 (By similarity). Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily. G-protein coupled receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway G-protein coupled acetylcholine receptor signaling pathway chemical synaptic transmission neuromuscular synaptic transmission postsynaptic density membrane integral component of membrane G-protein coupled acetylcholine receptor activity cell junction dendrite neurotransmitter receptor activity asymmetric synapse regulation of locomotion positive regulation of ion transport axon terminus synapse postsynaptic membrane saliva secretion cognition regulation of postsynaptic membrane potential positive regulation of intracellular protein transport glutamatergic synapse cholinergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane integral component of postsynaptic density membrane neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential uc008gmg.1 uc008gmg.2 uc008gmg.3 uc008gmg.4 uc008gmg.5 
ENSMUST00000163790.2 Gm3558 ENSMUST00000163790.2 predicted gene 3558 (from RefSeq NM_001270842.1) ENSMUST00000163790.1 Gm10128 Gm3558 NM_001270842 Q5FWC9 Q5FWC9_MOUSE uc007seh.1 uc007seh.2 uc007seh.1 uc007seh.2 
ENSMUST00000163795.3 Gm17182 ENSMUST00000163795.3 predicted gene 17182 (from RefSeq NR_166509.1) ENSMUST00000163795.1 ENSMUST00000163795.2 NR_166509 uc008xkz.1 uc008xkz.2 uc008xkz.3 uc008xkz.1 uc008xkz.2 uc008xkz.3 
ENSMUST00000163802.2 Gm17139 ENSMUST00000163802.2 Gm17139 (from geneSymbol) ENSMUST00000163802.1 uc288hww.1 uc288hww.2 uc288hww.1 uc288hww.2 
ENSMUST00000163803.3 Vmn2r63 ENSMUST00000163803.3 vomeronasal 2, receptor 63 (from RefSeq NM_001105060.1) E9Q0K5 E9Q0K5_MOUSE ENSMUST00000163803.1 ENSMUST00000163803.2 NM_001105060 Vmn2r63 uc012fja.1 uc012fja.2 uc012fja.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012fja.1 uc012fja.2 uc012fja.3 
ENSMUST00000163808.2 Il22b ENSMUST00000163808.2 interleukin 22B (from RefSeq NM_054079.2) E9QAL9 ENSMUST00000163808.1 IL22B_MOUSE Il22b Iltifb NM_054079 Q9JJY8 uc007hdx.1 uc007hdx.2 uc007hdx.3 Cytokine that contributes to the inflammatory response in vivo. Secreted. Belongs to the IL-10 family. cytokine activity extracellular region extracellular space signal transduction uc007hdx.1 uc007hdx.2 uc007hdx.3 
ENSMUST00000163832.8 Gbe1 ENSMUST00000163832.8 1,4-alpha-glucan branching enzyme 1 (from RefSeq NM_028803.4) ENSMUST00000163832.1 ENSMUST00000163832.2 ENSMUST00000163832.3 ENSMUST00000163832.4 ENSMUST00000163832.5 ENSMUST00000163832.6 ENSMUST00000163832.7 GLGB_MOUSE NM_028803 Q9D6Y9 uc289fkn.1 uc289fkn.2 Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule. Reaction=Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.; EC=2.4.1.18; Evidence=; Glycan biosynthesis; glycogen biosynthesis. Monomer. Binds its carbohydrate substrate close to the active site, but also via regions close to the N-terminus; this may result in increased affinity and therefore increased catalytic efficiency. Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. catalytic activity 1,4-alpha-glucan branching enzyme activity hydrolase activity, hydrolyzing O-glycosyl compounds carbohydrate metabolic process glycogen biosynthetic process transferase activity transferase activity, transferring glycosyl groups carbohydrate binding cation binding uc289fkn.1 uc289fkn.2 
ENSMUST00000163839.3 Fbxw25 ENSMUST00000163839.3 F-box and WD-40 domain protein 25 (from RefSeq NM_001378643.1) ENSMUST00000163839.1 ENSMUST00000163839.2 F7C9P2 F7C9P2_MOUSE Fbxw13 Fbxw25 NM_001378643 uc009rsn.1 uc009rsn.2 uc009rsn.1 uc009rsn.2 
ENSMUST00000163865.8 Arhgap28 ENSMUST00000163865.8 Rho GTPase activating protein 28, transcript variant 2 (from RefSeq NM_001347410.1) ENSMUST00000163865.1 ENSMUST00000163865.2 ENSMUST00000163865.3 ENSMUST00000163865.4 ENSMUST00000163865.5 ENSMUST00000163865.6 ENSMUST00000163865.7 Kiaa1314 NM_001347410 Q3TSH7 Q3UR11 Q3UZQ7 Q69ZM1 Q6NY11 Q8BN58 RHG28_MOUSE uc057kyk.1 uc057kyk.2 uc057kyk.3 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BN58-1; Sequence=Displayed; Name=2; IsoId=Q8BN58-2; Sequence=VSP_023729, VSP_023730; Name=3; IsoId=Q8BN58-3; Sequence=VSP_023731; Sequence=BAE36698.1; Type=Erroneous initiation; Evidence=; GTPase activator activity cytoplasm signal transduction regulation of actin filament polymerization regulation of actin cytoskeleton organization positive regulation of GTPase activity regulation of small GTPase mediated signal transduction negative regulation of stress fiber assembly negative regulation of GTP binding uc057kyk.1 uc057kyk.2 uc057kyk.3 
ENSMUST00000163884.8 Tmem39a ENSMUST00000163884.8 transmembrane protein 39a, transcript variant 2 (from RefSeq NM_001205286.1) ENSMUST00000163884.1 ENSMUST00000163884.2 ENSMUST00000163884.3 ENSMUST00000163884.4 ENSMUST00000163884.5 ENSMUST00000163884.6 ENSMUST00000163884.7 NM_001205286 Q3TFJ2 Q9CYC3 TM39A_MOUSE uc029sxf.1 uc029sxf.2 uc029sxf.3 Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (By similarity). Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L (By similarity). Interacts with SACM1L, SEC23A and SEC24A. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CYC3-1; Sequence=Displayed; Name=2; IsoId=Q9CYC3-2; Sequence=VSP_023418; Belongs to the TMEM39 family. molecular_function cellular_component membrane integral component of membrane uc029sxf.1 uc029sxf.2 uc029sxf.3 
ENSMUST00000163892.8 4930523C07Rik ENSMUST00000163892.8 RIKEN cDNA 4930523C07 gene, transcript variant 1 (from RefSeq NM_001162896.1) 4930523C07Rik E9Q2T4 E9Q2T4_MOUSE ENSMUST00000163892.1 ENSMUST00000163892.2 ENSMUST00000163892.3 ENSMUST00000163892.4 ENSMUST00000163892.5 ENSMUST00000163892.6 ENSMUST00000163892.7 NM_001162896 uc007dec.1 uc007dec.2 uc007dec.3 uc007dec.4 uc007dec.5 membrane integral component of membrane uc007dec.1 uc007dec.2 uc007dec.3 uc007dec.4 uc007dec.5 
ENSMUST00000163893.8 Eps8l1 ENSMUST00000163893.8 EPS8-like 1, transcript variant 1 (from RefSeq NM_001290416.1) ENSMUST00000163893.1 ENSMUST00000163893.2 ENSMUST00000163893.3 ENSMUST00000163893.4 ENSMUST00000163893.5 ENSMUST00000163893.6 ENSMUST00000163893.7 ES8L1_MOUSE Eps8r1 NM_001290416 Q8R0D6 Q8R5F8 Q9D2M6 uc009exp.1 uc009exp.2 uc009exp.3 Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin (By similarity). Cytoplasm Detected in placenta, skin, mammary gland, bone marrow and stomach. Belongs to the EPS8 family. Sequence=BC027043; Type=Frameshift; Evidence=; ruffle actin binding Rho guanyl-nucleotide exchange factor activity cytoplasm cytosol plasma membrane Rho protein signal transduction Rac protein signal transduction Rac guanyl-nucleotide exchange factor activity ruffle membrane macromolecular complex regulation of Rho protein signal transduction T cell receptor binding actin filament binding positive regulation of ruffle assembly uc009exp.1 uc009exp.2 uc009exp.3 
ENSMUST00000163912.3 1700049E17Rik2 ENSMUST00000163912.3 tandem duplication of RIKEN cDNA 1700049E17 gene, gene 2 (from RefSeq NM_001358037.1) 1700049E17Rik1 1700049E17Rik2 E9Q8F7 ENSMUST00000163912.1 ENSMUST00000163912.2 F6QVC4 F6QVC4_MOUSE NM_001358037 uc288snz.1 uc288snz.2 molecular_function cellular_component biological_process uc288snz.1 uc288snz.2 
ENSMUST00000163940.2 C130050O18Rik ENSMUST00000163940.2 RIKEN cDNA C130050O18 gene (from RefSeq NM_001384195.1) C130050O18Rik ENSMUST00000163940.1 NM_001384195 Q497Y9 Q497Y9_MOUSE uc009ago.1 uc009ago.2 uc009ago.3 molecular_function cellular_component biological_process membrane integral component of membrane uc009ago.1 uc009ago.2 uc009ago.3 
ENSMUST00000163961.3 Slfn14 ENSMUST00000163961.3 schlafen 14 (from RefSeq NM_001166028.1) ENSMUST00000163961.1 ENSMUST00000163961.2 NM_001166028 SLN14_MOUSE Slfn14 V9GXG1 uc011ybg.1 uc011ybg.2 uc011ybg.3 [Protein SLFN14]: Shows no ribosome-associated and endoribonuclease activities. [C-terminally truncated SLFN14 endoribonuclease]: Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner. Involved in correct maturation of megakaryocytes and especially important for proplatelet extension (By similarity). Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=C-terminally truncated SLFN14 endoribonuclease: Requires manganese and magnesium for its endoribonuclease activity. ; [C-terminally truncated SLFN14 endoribonuclease]: Associates with ribosomes in an ATP-independent manner (PubMed:25996083). [Protein SLFN14]: Nucleus Expressed in spleen (PubMed:19619625). nuclease activity endonuclease activity endoribonuclease activity nucleus cytoplasm mRNA catabolic process rRNA catabolic process hydrolase activity platelet maturation ribosome binding cellular response to magnesium ion cellular response to manganese ion RNA phosphodiester bond hydrolysis, endonucleolytic uc011ybg.1 uc011ybg.2 uc011ybg.3 
ENSMUST00000163968.8 Dhx34 ENSMUST00000163968.8 DExH-box helicase 34 (from RefSeq NM_027883.3) A0A0R4J217 A0A0R4J217_MOUSE Dhx34 ENSMUST00000163968.1 ENSMUST00000163968.2 ENSMUST00000163968.3 ENSMUST00000163968.4 ENSMUST00000163968.5 ENSMUST00000163968.6 ENSMUST00000163968.7 NM_027883 uc009fhj.1 uc009fhj.2 nucleotide binding nuclear-transcribed mRNA catabolic process helicase activity ATP binding hydrolase activity negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay uc009fhj.1 uc009fhj.2 
ENSMUST00000163970.9 Gm10375 ENSMUST00000163970.9 predicted gene 10375 (from RefSeq NM_001098269.2) ENSMUST00000163970.1 ENSMUST00000163970.2 ENSMUST00000163970.3 ENSMUST00000163970.4 ENSMUST00000163970.5 ENSMUST00000163970.6 ENSMUST00000163970.7 ENSMUST00000163970.8 Gm10375 NM_001098269 Q5EBJ2 Q5EBJ2_MOUSE uc288ssc.1 uc288ssc.2 molecular_function cellular_component biological_process uc288ssc.1 uc288ssc.2 
ENSMUST00000163991.4 Smpd5 ENSMUST00000163991.4 sphingomyelin phosphodiesterase 5 (from RefSeq NM_001195537.2) D6MZJ6 ENSMUST00000163991.1 ENSMUST00000163991.2 ENSMUST00000163991.3 Gm10345 NM_001195537 NSMA5_MOUSE Smpd5 uc011zut.1 uc011zut.2 uc011zut.3 Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:295975; EC=3.1.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19254; Evidence=; Reaction=H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-hexadecanoylsphing-4-enine + phosphocholine; Xref=Rhea:RHEA:45644, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72959, ChEBI:CHEBI:78646, ChEBI:CHEBI:295975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45645; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Activated by anionic phospholipids, specially cardiolipin and phosphatidylserine. pH dependence: Optimum pH is 7.5. ; Lipid metabolism; sphingolipid metabolism. Mitochondrion inner membrane ; Single-pass type II membrane protein ; Intermembrane side Endoplasmic reticulum membrane ; Single-pass membrane protein Highly expressed in testis, pancreas, epididymis, and brain. Belongs to the neutral sphingomyelinase family. phospholipase activity sphingomyelin phosphodiesterase activity cytoplasm mitochondrion ceramide metabolic process sphingomyelin metabolic process membrane integral component of membrane uc011zut.1 uc011zut.2 uc011zut.3 
ENSMUST00000164016.8 Pnpla2 ENSMUST00000164016.8 patatin-like phospholipase domain containing 2, transcript variant 1 (from RefSeq NM_001163689.1) Atgl ENSMUST00000164016.1 ENSMUST00000164016.2 ENSMUST00000164016.3 ENSMUST00000164016.4 ENSMUST00000164016.5 ENSMUST00000164016.6 ENSMUST00000164016.7 NM_001163689 O89080 PLPL2_MOUSE Pnpla2 Q05BJ0 Q3UD97 Q643S0 Q6P234 Q8BJ56 Q9D1Q9 Q9DCF6 uc009kli.1 uc009kli.2 uc009kli.3 uc009kli.4 Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674, PubMed:23066022, PubMed:15337759, PubMed:16150821, PubMed:16679289, PubMed:17074755, PubMed:16675698, PubMed:17114792). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (PubMed:23066022). Also possesses acylglycerol transacylase and phospholipase A2 activities (By similarity). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (By similarity). Regulates adiposome size and may be involved in the degradation of adiposomes (By similarity). May play an important role in energy homeostasis (PubMed:16675698). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (PubMed:15337759). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (PubMed:35676490). Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12045; Evidence=; Reaction=a triacyl-sn-glycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:44864, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:49172, ChEBI:CHEBI:64615; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44865; Evidence=; Reaction=a triacyl-sn-glycerol + H2O = a 2,3-diacyl-sn-glycerol + a fatty acid + H(+); Xref=Rhea:RHEA:38499, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:64615, ChEBI:CHEBI:75524; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38500; Evidence=; Reaction=a triacyl-sn-glycerol + H2O = a 1,3-diacyl-sn-glycerol + a fatty acid + H(+); Xref=Rhea:RHEA:43732, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:64615, ChEBI:CHEBI:77272; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43733; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38387, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75735; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38388; Evidence=; Reaction=1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+); Xref=Rhea:RHEA:38395, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:75841, ChEBI:CHEBI:75849; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38396; Evidence=; Reaction=1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)- octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+); Xref=Rhea:RHEA:38403, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:75844, ChEBI:CHEBI:75850; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38404; Evidence=; Reaction=1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)- octadecatrienoylglycerol + H(+); Xref=Rhea:RHEA:38411, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32387, ChEBI:CHEBI:75845, ChEBI:CHEBI:75852; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38412; Evidence=; Reaction=1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = 1,3- di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:38419, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:75735, ChEBI:CHEBI:75846; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38420; Evidence=; Reaction=1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38423, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75583, ChEBI:CHEBI:75867; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38424; Evidence=; Reaction=1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38647, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75847, ChEBI:CHEBI:75868; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38648; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38391, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75824; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38392; Evidence=; Reaction=1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:75841, ChEBI:CHEBI:75853; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38400; Evidence=; Reaction=1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)- octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38407, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:75844, ChEBI:CHEBI:75854; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38408; Evidence=; Reaction=1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)- octadecatrienoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38415, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32387, ChEBI:CHEBI:75845, ChEBI:CHEBI:75855; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38416; Evidence=; Reaction=1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = (9Z)- octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75846, ChEBI:CHEBI:75870; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38432; Evidence=; Reaction=1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:38427, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:75824, ChEBI:CHEBI:75847; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38428; Evidence=; Reaction=1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38643, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75546, ChEBI:CHEBI:75583; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38644; Evidence=; Reaction=(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O; Xref=Rhea:RHEA:38379, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52323, ChEBI:CHEBI:53753; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38381; Evidence=; Reaction=a 1,3-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol; Xref=Rhea:RHEA:44440, ChEBI:CHEBI:17754, ChEBI:CHEBI:17855, ChEBI:CHEBI:35759, ChEBI:CHEBI:47777; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44441; Evidence=; Reaction=a 1,2-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol; Xref=Rhea:RHEA:44436, ChEBI:CHEBI:17754, ChEBI:CHEBI:17855, ChEBI:CHEBI:35759, ChEBI:CHEBI:49172; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44437; Evidence=; Reaction=2 a 1-acylglycerol = a 1,2-diacylglycerol + glycerol; Xref=Rhea:RHEA:44432, ChEBI:CHEBI:17754, ChEBI:CHEBI:35759, ChEBI:CHEBI:49172; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44433; Evidence=; Reaction=a triacyl-sn-glycerol + all-trans-retinol = a diacylglycerol + an all-trans-retinyl ester; Xref=Rhea:RHEA:44676, ChEBI:CHEBI:17336, ChEBI:CHEBI:18035, ChEBI:CHEBI:63410, ChEBI:CHEBI:64615; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44677; Evidence=; Reaction=1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)- glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol; Xref=Rhea:RHEA:38331, ChEBI:CHEBI:17754, ChEBI:CHEBI:53753, ChEBI:CHEBI:75342, ChEBI:CHEBI:75735; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38332; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)- glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol; Xref=Rhea:RHEA:38327, ChEBI:CHEBI:17754, ChEBI:CHEBI:52323, ChEBI:CHEBI:53753, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38328; Evidence=; Reaction=2 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)- glycerol + glycerol; Xref=Rhea:RHEA:38323, ChEBI:CHEBI:17754, ChEBI:CHEBI:52323, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38324; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol; Xref=Rhea:RHEA:39987, ChEBI:CHEBI:17336, ChEBI:CHEBI:53753, ChEBI:CHEBI:70760, ChEBI:CHEBI:75945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39988; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate = 9-(9Z-octadecenoyloxy)-octadecanoate + di-(9Z)- octadecenoylglycerol; Xref=Rhea:RHEA:75011, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945, ChEBI:CHEBI:136282, ChEBI:CHEBI:136286; Evidence=; Reaction=1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9- hydroxy-octadecanoate = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9- hexadecanoyloxy-octadecanoate; Xref=Rhea:RHEA:75015, ChEBI:CHEBI:75824, ChEBI:CHEBI:75847, ChEBI:CHEBI:83670, ChEBI:CHEBI:136286; Evidence=; Reaction=1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy- octadecanoate = 9-(10Z-heptadecenoyloxy)-octadecanoate + di-(10Z)- heptadecenoylglycerol; Xref=Rhea:RHEA:75019, ChEBI:CHEBI:136286, ChEBI:CHEBI:194143, ChEBI:CHEBI:194144, ChEBI:CHEBI:194145; Evidence=; Reaction=1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy- octadecanoate = 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate + di- (9Z,12Z)-octadecadienoylglycerol; Xref=Rhea:RHEA:75023, ChEBI:CHEBI:75844, ChEBI:CHEBI:136286, ChEBI:CHEBI:138658, ChEBI:CHEBI:194142; Evidence=; Reaction=1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate = 9-(9Z-hexadecenoyloxy)-octadecanoate + di-(9Z)- hexadecenoylglycerol; Xref=Rhea:RHEA:75027, ChEBI:CHEBI:75841, ChEBI:CHEBI:136286, ChEBI:CHEBI:136309, ChEBI:CHEBI:194140; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate = (9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate; Xref=Rhea:RHEA:75031, ChEBI:CHEBI:52333, ChEBI:CHEBI:75937, ChEBI:CHEBI:136282, ChEBI:CHEBI:136286; Evidence=; Reaction=1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9- hydroxy-octadecanoate = 1-hexadecanoyl-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate; Xref=Rhea:RHEA:75035, ChEBI:CHEBI:75847, ChEBI:CHEBI:136282, ChEBI:CHEBI:136286, ChEBI:CHEBI:194141; Evidence=; Stimulated by PKA-dependent PLIN phosphorylation. Glycerolipid metabolism; triacylglycerol degradation. Interacts with ABHD5; this association stimulates PNPLA2 triglyceride hydrolase activity (PubMed:16679289, PubMed:17189257). Interacts with SERPINF1; this interaction stimulates the phospholipase A2 activity of PNPLA2 (By similarity). Despite a colocalization in lipid droplets, it probably does not interact with PLIN (PubMed:17189257). Interacts with PLIN5; prevents interaction with ABHD5 (PubMed:21148142, PubMed:21393244). Interacts with FAF2 (By similarity). Lipid droplet ll membrane ; Multi-pass membrane protein Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BJ56-1; Sequence=Displayed; Name=2; IsoId=Q8BJ56-2; Sequence=VSP_026424; Name=3; IsoId=Q8BJ56-3; Sequence=VSP_026422, VSP_026423; Expressed at high levels in white and brown adipose tissue, and to a lesser degree in testis and cardiac muscle. Barely detected in liver, spleen, thymus, kidney, skeletal muscle, and brain. Among the white adipose depots, gonadal fat showed the highest level of expression compared with inguinal and renal white adipose tissues. Increased expression when preadipocytes are induced to differentiate to adipocytes. Not detected in proliferating or confluent preadipocytes. Transiently induced during fasting. cAMP and glucagon may not be involved in the induction during fasting. Induced by dexamethasone. Down-regulated by insulin, isoprotenerol and TNF-alfa. Expression is not affected by glucose and by growth hormone. Expression is reduced in fasted leptin deficient mouse (ob/ob), an obese mouse model. Expression is not affected in fed ob/ob mouse. Phosphorylation at Ser-406 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity. Ubiquitinated by PEX2 in response to reactive oxygen species (ROS), leading to its degradation. Mice show increased adipose mass and triacylglycerol deposition in multiple tissues. They accumulate large amounts of lipid in the heart, causing cardiac dysfunction and premature death (PubMed:16675698). Conditional knockout in adipose cells results in a marked reduction in the levels and biosynthesis of fatty acid esters of hydroxy fatty acids (FAHFAs) and FAHFA-TGs (PubMed:35676490). Sequence=BAB22643.1; Type=Frameshift; Evidence=; triglyceride lipase activity protein binding nucleoplasm cytoplasm lipid particle cytosol plasma membrane lipid metabolic process negative regulation of sequestering of triglyceride positive regulation of triglyceride catabolic process membrane integral component of membrane lipid catabolic process hydrolase activity triglyceride catabolic process lipid storage lipid particle organization cellular lipid catabolic process lipid homeostasis uc009kli.1 uc009kli.2 uc009kli.3 uc009kli.4 
ENSMUST00000164026.8 Gml ENSMUST00000164026.8 glycosylphosphatidylinositol anchored molecule like, transcript variant 2 (from RefSeq NM_001415959.1) E9PX31 E9PX31_MOUSE ENSMUST00000164026.1 ENSMUST00000164026.2 ENSMUST00000164026.3 ENSMUST00000164026.4 ENSMUST00000164026.5 ENSMUST00000164026.6 ENSMUST00000164026.7 Gml NM_001415959 uc011zue.1 uc011zue.2 uc011zue.3 molecular_function cellular_component biological_process uc011zue.1 uc011zue.2 uc011zue.3 
ENSMUST00000164032.2 Gm17118 ENSMUST00000164032.2 Gm17118 (from geneSymbol) ENSMUST00000164032.1 uc292kts.1 uc292kts.2 uc292kts.1 uc292kts.2 
ENSMUST00000164034.8 Rhobtb1 ENSMUST00000164034.8 Rho-related BTB domain containing 1, transcript variant 2 (from RefSeq NM_001252636.1) B2RPX3 ENSMUST00000164034.1 ENSMUST00000164034.2 ENSMUST00000164034.3 ENSMUST00000164034.4 ENSMUST00000164034.5 ENSMUST00000164034.6 ENSMUST00000164034.7 NM_001252636 Q9DAK3 RHBT1_MOUSE uc029qyr.1 uc029qyr.2 uc029qyr.3 uc029qyr.4 Highest expression in heart and testis. Belongs to the small GTPase superfamily. Rho family. nucleotide binding GTPase activity protein binding GTP binding cytoplasm cell cortex actin filament organization small GTPase mediated signal transduction Rho protein signal transduction regulation of cell shape protein kinase binding regulation of cell migration establishment or maintenance of actin cytoskeleton polarity cell division site regulation of actin cytoskeleton organization intracellular membrane-bounded organelle actin filament bundle assembly plasma membrane uc029qyr.1 uc029qyr.2 uc029qyr.3 uc029qyr.4 
ENSMUST00000164044.8 Fcgr3 ENSMUST00000164044.8 Fc receptor, IgG, low affinity III, transcript variant 1 (from RefSeq NM_010188.5) A0A0B4J1M6 A0A0B4J1M6_MOUSE ENSMUST00000164044.1 ENSMUST00000164044.2 ENSMUST00000164044.3 ENSMUST00000164044.4 ENSMUST00000164044.5 ENSMUST00000164044.6 ENSMUST00000164044.7 Fcgr3 NM_010188 uc011wvw.1 uc011wvw.2 uc011wvw.3 membrane integral component of membrane uc011wvw.1 uc011wvw.2 uc011wvw.3 
ENSMUST00000164045.2 Vmn1r166 ENSMUST00000164045.2 vomeronasal 1 receptor 166 (from RefSeq NM_001167168.1) D3YTY2 D3YTY2_MOUSE ENSMUST00000164045.1 NM_001167168 Vmn1r111 Vmn1r131 Vmn1r138 Vmn1r166 uc012fes.1 uc012fes.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fes.1 uc012fes.2 
ENSMUST00000164056.9 Zfp710 ENSMUST00000164056.9 zinc finger protein 710, transcript variant 2 (from RefSeq NM_001145999.2) ENSMUST00000164056.1 ENSMUST00000164056.2 ENSMUST00000164056.3 ENSMUST00000164056.4 ENSMUST00000164056.5 ENSMUST00000164056.6 ENSMUST00000164056.7 ENSMUST00000164056.8 NM_001145999 Q3U288 Q3U341 Q3U396 Q6P9R3 Q8BJH0 Q8BTL6 Q8BZ48 ZN710_MOUSE Znf710 uc009hzj.1 uc009hzj.2 uc009hzj.3 uc009hzj.4 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U288-1; Sequence=Displayed; Name=2; IsoId=Q3U288-2; Sequence=VSP_018152; Name=3; IsoId=Q3U288-3; Sequence=VSP_026943; Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAH58640.3; Type=Erroneous initiation; Evidence=; Sequence=AAH60641.1; Type=Erroneous initiation; Evidence=; Sequence=BAC40892.1; Type=Erroneous initiation; Evidence=; nucleic acid binding DNA binding nucleus metal ion binding uc009hzj.1 uc009hzj.2 uc009hzj.3 uc009hzj.4 
ENSMUST00000164057.9 Gm5893 ENSMUST00000164057.9 Gm5893 (from geneSymbol) BC100485 ENSMUST00000164057.1 ENSMUST00000164057.2 ENSMUST00000164057.3 ENSMUST00000164057.4 ENSMUST00000164057.5 ENSMUST00000164057.6 ENSMUST00000164057.7 ENSMUST00000164057.8 uc291mvy.1 uc291mvy.2 uc291mvy.3 uc291mvy.1 uc291mvy.2 uc291mvy.3 
ENSMUST00000164064.2 Gm6133 ENSMUST00000164064.2 Belongs to the universal ribosomal protein uL22 family. (from UniProt B2RY53) B2RY53 B2RY53_MOUSE BC158101 EG620155 ENSMUST00000164064.1 Gm6133 uc289psp.1 uc289psp.2 Belongs to the universal ribosomal protein uL22 family. cytoplasmic translation structural constituent of ribosome ribosome translation large ribosomal subunit cytosolic large ribosomal subunit uc289psp.1 uc289psp.2 
ENSMUST00000164069.8 Gm3047 ENSMUST00000164069.8 Gm3047 (from geneSymbol) ENSMUST00000164069.1 ENSMUST00000164069.2 ENSMUST00000164069.3 ENSMUST00000164069.4 ENSMUST00000164069.5 ENSMUST00000164069.6 ENSMUST00000164069.7 Gm3047 L7N2D6 L7N2D6_MOUSE uc288qjz.1 uc288qjz.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qjz.1 uc288qjz.2 
ENSMUST00000164074.3 Gm17196 ENSMUST00000164074.3 Gm17196 (from geneSymbol) ENSMUST00000164074.1 ENSMUST00000164074.2 uc287qtk.1 uc287qtk.2 uc287qtk.3 uc287qtk.1 uc287qtk.2 uc287qtk.3 
ENSMUST00000164082.9 Cby2 ENSMUST00000164082.9 chibby family member 2, transcript variant 1 (from RefSeq NM_001164139.1) CBY2_MOUSE ENSMUST00000164082.1 ENSMUST00000164082.2 ENSMUST00000164082.3 ENSMUST00000164082.4 ENSMUST00000164082.5 ENSMUST00000164082.6 ENSMUST00000164082.7 ENSMUST00000164082.8 NM_001164139 Nurit Q32MG2 Q8CIV5 Q9D9E6 Q9D9Z0 Spert uc011zoo.1 uc011zoo.2 uc011zoo.3 Homodimer. Binds to NEK1. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q32MG2-1; Sequence=Displayed; Name=2; IsoId=Q32MG2-2; Sequence=VSP_028676, VSP_028677; Name=3; IsoId=Q32MG2-3; Sequence=VSP_028675; Testis-specific (PubMed:33536340). Expression is restricted to the flower-like structure in spermatids. Expressed through the elongation stage of the spermatids but absent from mature spermatozoa. Belongs to the chibby family. SPERT subfamily. Sequence=BAB24530.1; Type=Erroneous initiation; Evidence=; cytoplasmic vesicle identical protein binding centriole negative regulation of Wnt signaling pathway ciliary basal body cilium assembly ciliary transition zone assembly uc011zoo.1 uc011zoo.2 uc011zoo.3 
ENSMUST00000164097.4 Ihh ENSMUST00000164097.4 Indian hedgehog, transcript variant 1 (from RefSeq NM_010544.3) ENSMUST00000164097.1 ENSMUST00000164097.2 ENSMUST00000164097.3 IHH_MOUSE Ihh NM_010544 P97812 Q61724 uc007bnl.1 uc007bnl.2 uc007bnl.3 uc007bnl.4 [Indian hedgehog protein]: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C- terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Plays a role in hedgehog paracrine signaling. Associated with the very-low- density lipoprotein (VLDL) particles to function as a circulating morphogen for endothelial cell integrity maintenance (By similarity). [Indian hedgehog protein N-product]: The dually lipidated indian hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity). Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton (PubMed:10465785, PubMed:10631175). Positively regulates PTHLH during endochondral bone formation preventing chondrocyte hypertrophy. In contrast, Ihh is necessary for normal chondrocyte proliferation in a PTHLH-independent pathway (PubMed:10631175). [Indian hedgehog protein]: Reaction=cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]- C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl- [protein]; Xref=Rhea:RHEA:59504, Rhea:RHEA-COMP:12707, Rhea:RHEA- COMP:15369, Rhea:RHEA-COMP:15374, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:65250, ChEBI:CHEBI:143135, ChEBI:CHEBI:143140; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59505; Evidence=; [Indian hedgehog protein N-product]: Multimer. Interacts with BOC and CDON. Interacts with PTCH1 (By similarity). Interacts with glypican GPC3 (PubMed:23665349). [Indian hedgehog protein N-product]: Cell membrane ; Lipid-anchor Note=The N-product remains associated with the cell surface. [Indian hedgehog protein]: Endoplasmic reticulum membrane Golgi apparatus membrane Secreted Note=Co-localizes with HHAT in the ER and Golgi membrane. In the adult kidney, found in proximal convoluted and proximal straight tubule. Detected at 10 dpc in developing gut, at 14.5 days dpc in the cartilage primordium and in the developing urogenital sinus. Expression increases with gestional age in kidney and duodenum, becoming maximal in adulthood. [Indian hedgehog protein N-product]: Binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein- protein interactions mediated by this domain. [Indian hedgehog protein N-product]: Cholesterylation is required for N-product targeting to lipid rafts and multimerization. [Indian hedgehog protein]: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C- terminal of the newly generated N-product (By similarity). The N- product is the active species in both local and long-range signaling, whereas the C-product is degraded in the reticulum endoplasmic (By similarity). [Indian hedgehog protein N-product]: N-palmitoylation by HHAT of N-product is required for indian hedgehog protein N-product multimerization and full activity. Almost half of homozygous embryos mice for IHH died between 10.5 and 12.5 dpc. Also some lethality occurred in late gestation, most of the remaining embryos developed to term but died at birth, due to respiratory failure. Mutants display markedly reduced chondrocyte proliferation, maturation of chondrocytes at inappropriate position, and a failure of osteoblast development in endochondral bones. Belongs to the hedgehog family. Sequence=AAB49692.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; skeletal system development ossification branching involved in blood vessel morphogenesis osteoblast differentiation in utero embryonic development cell fate specification morphogenesis of a branching structure vasculature development heart looping positive regulation of mesenchymal cell proliferation epithelial cell morphogenesis retinal pigment epithelium development chondrocyte differentiation involved in endochondral bone morphogenesis patched binding calcium ion binding protein binding extracellular region extracellular space plasma membrane proteoglycan metabolic process proteolysis smoothened signaling pathway cell-cell signaling multicellular organism development pattern specification process peptidase activity positive regulation of cell proliferation response to mechanical stimulus embryonic pattern specification regulation of gene expression membrane intein-mediated protein splicing hydrolase activity cell differentiation vitelline membrane formation extracellular matrix pancreas development response to estradiol positive regulation of collagen biosynthetic process negative regulation of T cell differentiation in thymus negative regulation of immature T cell proliferation in thymus positive regulation of T cell differentiation in thymus multicellular organism growth chondrocyte proliferation regulation of growth embryonic digit morphogenesis camera-type eye development negative regulation of apoptotic process bone resorption negative regulation of cell differentiation positive regulation of smoothened signaling pathway positive regulation of transcription from RNA polymerase II promoter positive regulation of alpha-beta T cell differentiation negative regulation of alpha-beta T cell differentiation metal ion binding negative regulation of eye pigmentation cell maturation embryonic digestive tract morphogenesis embryonic camera-type eye morphogenesis neuron development smooth muscle tissue development positive regulation of epithelial cell proliferation cartilage development maternal process involved in female pregnancy camera-type eye photoreceptor cell fate commitment head morphogenesis somite development embryonic skeletal joint development epithelial cell-cell adhesion liver regeneration uc007bnl.1 uc007bnl.2 uc007bnl.3 uc007bnl.4 
ENSMUST00000164099.3 Snx19 ENSMUST00000164099.3 sorting nexin 19 (from RefSeq NM_028874.2) ENSMUST00000164099.1 ENSMUST00000164099.2 Kiaa0254 NM_028874 Q3TQ83 Q6P4T1 Q80U53 SNX19_MOUSE Snx19 uc009oqy.1 uc009oqy.2 uc009oqy.3 Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin- containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25148684). Interacts with PTPRN. Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)). Belongs to the sorting nexin family. Sequence=BAC65513.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; chondrocyte differentiation cytoplasm endosome exocytosis lipid binding protein transport membrane insulin secretion cytoplasmic vesicle membrane cytoplasmic vesicle early endosome membrane phosphatidylinositol-3-phosphate binding phosphatidylinositol binding dense core granule maturation uc009oqy.1 uc009oqy.2 uc009oqy.3 
ENSMUST00000164101.8 Ikbkg ENSMUST00000164101.8 inhibitor of kappaB kinase gamma, transcript variant 6 (from RefSeq NM_001161423.1) ENSMUST00000164101.1 ENSMUST00000164101.2 ENSMUST00000164101.3 ENSMUST00000164101.4 ENSMUST00000164101.5 ENSMUST00000164101.6 ENSMUST00000164101.7 NEMO_MOUSE NM_001161423 Nemo O88522 Q924H4 uc009tpe.1 uc009tpe.2 uc009tpe.3 Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:9927690). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways. Can recognize and bind both 'Lys- 63'-linked and linear polyubiquitin upon cell stimulation, with a much highr affinity for linear polyubiquitin. Could be implicated in NF- kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity). Homodimer; disulfide-linked (By similarity). Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits (PubMed:11080499). The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK- signalosome holo-complex (PubMed:11080499). The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65 (PubMed:20622870). Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP (By similarity). Interacts with COPS3, CYLD, NALP2, TRPC4AP and PIDD1 (By similarity). Interacts with ATM; the complex is exported from the nucleus (By similarity). Interacts with TRAF6 (By similarity). Interacts with IKBKE (By similarity). Interacts with TANK; the interaction is enhanced by IKBKE and TBK1 (By similarity). Part of a ternary complex consisting of TANK, IKBKB and IKBKG (PubMed:12133833). Interacts with ZFAND5 (By similarity). Interacts with RIPK2 (By similarity). Interacts with TNIP1 and TNFAIP3; TNIP1 facilitates the TNFAIP3-mediated de-ubiquitination of IKBKG (By similarity). Interacts with TNFAIP3; the interaction is induced by TNF stimulation and by polyubiquitin (By similarity). Binds (via UBAN region) polyubiquitin; binds both 'Lys-63'-linked and linear polyubiquitin, with higher affinity for linear ubiquitin (PubMed:19303852, PubMed:19854204). Interacts with NLRP10 (By similarity). Interacts with TANK; this interaction increases in response to DNA damage (By similarity). Interacts with USP10; this interaction increases in response to DNA damage (By similarity). Interacts with ZC3H12A; this interaction increases in response to DNA damage (By similarity). Interacts with IFIT5; the interaction synergizes the recruitment of IKK to MAP3K7 and enhances IKK phosphorylation (By similarity). Interacts with TRIM29; this interaction induces IKBKG/NEMO ubiquitination and proteolytic degradation (By similarity). Interacts with TRIM13; this interaction leads to IKBKG/NEMO ubiquitination (By similarity). Interacts with ARFIP2 (By similarity). Interacts with RIPK1 (PubMed:31519886). Interacts with (ubiquitinated) BCL10; interaction with polyubiquitinated BCL10 via both 'Lys-63'-linked and linear ubiquitin is required for TCR-induced NF-kappa-B activation (By similarity). Interacts with MARCHF2; during the late stages of macrophage viral and bacterial infection; the interaction leads to ubiquitination and degradation of IKBKG/NEMO (PubMed:32935379). O88522; Q60680: Chuk; NbExp=6; IntAct=EBI-998011, EBI-646245; O88522; O88351: Ikbkb; NbExp=8; IntAct=EBI-998011, EBI-447960; O88522; O88522: Ikbkg; NbExp=2; IntAct=EBI-998011, EBI-998011; O88522; Q924T7: Rnf31; NbExp=7; IntAct=EBI-998011, EBI-647680; O88522; P62991: Ubc; NbExp=3; IntAct=EBI-998011, EBI-413074; O88522; P24772: OPG200; Xeno; NbExp=2; IntAct=EBI-998011, EBI-4291651; O88522; P0CG48: UBC; Xeno; NbExp=3; IntAct=EBI-998011, EBI-3390054; Cytoplasm Nucleus Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress. The leucine-zipper domain and the CCHC NOA-type zinc-fingers constitute the UBAN region and are essential for polyubiquitin binding and for the activation of IRF3. Phosphorylation at Ser-68 attenuates aminoterminal homodimerization. Polyubiquitinated on Lys-278 via 'Lys-63'-linked ubiquitin; the ubiquitination is mediated downstream of NOD2 and RIPK2 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway (By similarity). Polyubiquitinated on Lys-278 and Lys-302 through 'Lys-63'- linked ubiquitin; the ubiquitination is mediated by BCL10, MALT1 and TRAF6 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway (By similarity). Monoubiquitinated on Lys-270 and Lys-302; promotes nuclear export (By similarity). Polyubiquitinated through 'Lys-27' by TRIM23; involved in antiviral innate and inflammatory responses (By similarity). Linear polyubiquitinated on Lys-111, Lys-143, Lys-226, Lys-246, Lys-270, Lys-278, Lys-285, Lys-295, Lys-302 and Lys-319; the head-to-tail polyubiquitination is mediated by the LUBAC complex and plays a key role in NF-kappa-B activation (By similarity). Deubiquitinated by USP10 in a TANK-dependent and -independent manner, leading to the negative regulation of NF-kappa-B signaling upon DNA damage (By similarity). Ubiquitinated at Lys-319 by MARCHF2 following bacterial and viral infection which leads to its degradation (By similarity). Polyubiquitinated via 'Lys-29'-linked ubiquitin; leading to lysosomal degradation (By similarity). Sumoylated on Lys-270 and Lys-302 with SUMO1; the modification results in phosphorylation of Ser-85 by ATM leading to a replacement of the sumoylation by mono-ubiquitination on these residues. Neddylated by TRIM40, resulting in stabilization of NFKBIA and down-regulation of NF-kappa-B activity. ubiquitin ligase complex spindle pole B cell homeostasis protein binding nucleus cytoplasm cytosol cellular response to DNA damage stimulus activation of NF-kappaB-inducing kinase activity IkappaB kinase complex positive regulation of gene expression positive regulation of macroautophagy protein domain specific binding ubiquitin protein ligase binding identical protein binding protein homodimerization activity peroxisome proliferator activated receptor binding positive regulation of I-kappaB kinase/NF-kappaB signaling anoikis positive regulation of transcription from RNA polymerase II promoter metal ion binding protein heterodimerization activity positive regulation of NF-kappaB transcription factor activity establishment of vesicle localization K63-linked polyubiquitin binding mitotic spindle negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway linear polyubiquitin binding uc009tpe.1 uc009tpe.2 uc009tpe.3 
ENSMUST00000164106.2 ENSMUSG00000121622 ENSMUST00000164106.2 ENSMUSG00000121622 (from geneSymbol) ENSMUST00000164106.1 uc291vio.1 uc291vio.2 uc291vio.1 uc291vio.2 
ENSMUST00000164107.3 Bcr ENSMUST00000164107.3 BCR activator of RhoGEF and GTPase (from RefSeq NM_001081412.3) BCR_MOUSE Bcr E9PZL3 ENSMUST00000164107.1 ENSMUST00000164107.2 Kiaa3017 NM_001081412 Q61339 Q6PAJ1 Q6ZPE5 Q99LW5 uc007fqb.1 uc007fqb.2 uc007fqb.3 uc007fqb.4 Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The amino terminus contains an intrinsic kinase activity (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (PubMed:20962234). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Homotetramer. Interacts with PDZK1. Interacts with HCK, FES/FPS, ABL1, PIK3R1 and GRB2 (By similarity). May interact with CCPG1 (PubMed:17000758). Interacts with SH2D5 (PubMed:25331951). Interacts with DLG4 (By similarity). Postsynaptic density Cell projection, dendritic spine Cell projection, axon Synapse Expressed in brain (PubMed:25331951). In hippocampal subregions, most abundant in the CA1 region and expressed at successively lower levels in the dentate gyrus and the CA3 region (PubMed:20962234). The DH domain is involved in interaction with CCPG1. The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene. The amino terminus contains an intrinsic kinase activity. The central Dbl homology (DH) domain functions as a guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The C-terminus is a Rho-GAP domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. The protein has a unique structure having two opposing regulatory activities toward small GTP- binding proteins. Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-178 by HCK is important for interaction with GRB2. Mutant mice show impaired spatial and object recognition memory with reduced maintenance of long-term potentiation (LTP) in Schaffer collateral-CA1 pyramidal neuron synapses. nucleotide binding negative regulation of cellular extravasation renal system process protein serine/threonine kinase activity guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity protein binding ATP binding cytoplasm cytosol plasma membrane protein phosphorylation signal transduction small GTPase mediated signal transduction brain development postsynaptic density membrane kinase activity phosphorylation transferase activity enzyme binding actin cytoskeleton organization cell junction keratinocyte differentiation negative regulation of cell migration axon response to lipopolysaccharide macromolecular complex regulation of Rho protein signal transduction intracellular signal transduction inner ear morphogenesis cell projection regulation of vascular permeability dendritic spine negative regulation of neutrophil degranulation positive regulation of GTPase activity synapse postsynaptic membrane protein autophosphorylation platelet-derived growth factor receptor signaling pathway focal adhesion assembly homeostasis of number of cells negative regulation of inflammatory response positive regulation of phagocytosis modulation of synaptic transmission neuromuscular process controlling balance regulation of nitrogen compound metabolic process regulation of cell cycle definitive hemopoiesis negative regulation of respiratory burst negative regulation of blood vessel remodeling intracellular protein transmembrane transport cellular response to lipopolysaccharide activation of GTPase activity glutamatergic synapse postsynaptic density, intracellular component negative regulation of reactive oxygen species metabolic process uc007fqb.1 uc007fqb.2 uc007fqb.3 uc007fqb.4 
ENSMUST00000164114.9 Ccdc141 ENSMUST00000164114.9 coiled-coil domain containing 141 (from RefSeq NM_001025576.3) A2AST1 CC141_MOUSE Camdi Ccdc141 E9Q8Q6 ENSMUST00000164114.1 ENSMUST00000164114.2 ENSMUST00000164114.3 ENSMUST00000164114.4 ENSMUST00000164114.5 ENSMUST00000164114.6 ENSMUST00000164114.7 ENSMUST00000164114.8 NM_001025576 uc012bxr.1 uc012bxr.2 uc012bxr.3 Plays a critical role in cortical radial and GnRH neurons migration during brain development (PubMed:20956536, PubMed:27014940). Regulates cortical radial migration by negatively controlling the activity of histone deacetylase 6 (HDAC6) and promotes centrosome maturation (PubMed:27737934). CAMDI is required for dilation formation of cortical neurons during radial migration (PubMed:34298015). Plays a critical role in learning and memory performance through regulation of AMPA-selective glutamate receptors (AMPARs) cell surface expression in competition with KIBRA (PubMed:27014940). Interacts with DISC1. Interacts preferentially with phosphorylated forms of myosin regulatory light chain (MRLC) (PubMed:20956536). Interacts (via the N-terminal region) with HDAC6; inhibits the deacetylase activity of HDAC6 (By similarity). Interacts with KIBRA (via the C-terminal region); retains AMPAR in the cytosol after internalization (PubMed:31730661). Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Co- localized with DISC1 at/around the centrosome. Localizes to the centrosome, at least in part, in a DISC1-dependent manner (PubMed:20956536). Accumulates and oscillates at the dilation in cortical neurons during migration (PubMed:34298015). CAMDI protein level is stabilized at the G1 phase and destabilized at the G2 /M phase (PubMed:34298015). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q8Q6-1; Sequence=Displayed; Name=2; IsoId=E9Q8Q6-2; Sequence=VSP_062009, VSP_062010; Between 11.5 and 15.5 dpc, CCDC141 is robustly expressed in migrating GnRH neurons, cells in the developing vomeronasal organ and olfactory axons. Detected also in sensory neurons, cell bodies and axons, in the dorsal root and trigeminal ganglia and within cortical structures within the CNS between 11.5 and 15.5 dpc. Ubiquitinated and degradated by the CDC20-APC/C pathway. During brain development, CDC20-APC/C complex degrades CCDC141 after centrosome translocation into the dilated area. CCDC141 is restabilized in the dilation until the centrosome enters the dilation, at which point it is once again immediately destabilized by CDC20-APC/C complex. The oscillatory regulation of CCDC141 protein is needed for proper cortical migration. Phosphorylation at Thr-91 by PLK1 affects CCDC141 degradation. Knockout mice are born at the expected Mendelian frequency and are viable and fertile; they have normal body weight at birth and during the juvenile stage. Adult knockout mice have a normal appearance and exhibited no obvious changes in overall brain weight or morphology. However deficient mice show delayed cortical migration and abnormal behaviors associated with psychiatric disorders (PubMed:27737934). Deficient mice exhibit impaired recognition memory and spatial reference memory (PubMed:31730661). protein binding cytoplasm centrosome plasma membrane homophilic cell adhesion via plasma membrane adhesion molecules axon guidance membrane integral component of membrane cerebral cortex radially oriented cell migration axon centrosome localization dendrite self-avoidance protein binding involved in cell-cell adhesion uc012bxr.1 uc012bxr.2 uc012bxr.3 
ENSMUST00000164148.8 Serpina16 ENSMUST00000164148.8 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16 (from RefSeq NM_001310472.1) D3Z660 D3Z660_MOUSE ENSMUST00000164148.1 ENSMUST00000164148.2 ENSMUST00000164148.3 ENSMUST00000164148.4 ENSMUST00000164148.5 ENSMUST00000164148.6 ENSMUST00000164148.7 Gm46 NM_001310472 Serpina16 uc288ivy.1 uc288ivy.2 Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular space negative regulation of endopeptidase activity uc288ivy.1 uc288ivy.2 
ENSMUST00000164163.8 Sla ENSMUST00000164163.8 src-like adaptor, transcript variant 2 (from RefSeq NM_009192.4) ENSMUST00000164163.1 ENSMUST00000164163.2 ENSMUST00000164163.3 ENSMUST00000164163.4 ENSMUST00000164163.5 ENSMUST00000164163.6 ENSMUST00000164163.7 NM_009192 Q60898 Q8C9Q8 Q8CAT0 Q8CBE9 Q8QZX8 SLAP1_MOUSE Slap Slap1 uc007was.1 uc007was.2 uc007was.3 uc007was.4 Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Homodimer. Interacts with phosphorylated CBL, SYK and LAT. Homodimerization and interaction with phosphorylated CBL occurs via its C-terminal domain (By similarity). Interacts with PDGFRB and EPHA2. Interacts with phosphorylated proteins ZAP70; CD3Z; VAV1 and LCP2 via its SH2 domain. Cytoplasm Endosome Note=Colocalizes with endosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60898-1; Sequence=Displayed; Name=2; IsoId=Q60898-2; Sequence=VSP_007239; Predominantly expressed in lymphoid tissues. Highly expressed in spleen, thymus and lymph nodes. Weakly expressed in lung and brain. Expressed in T-cells and at low level in B-cells. Expressed during thymocyte maturation. Weakly expressed in CD4(-) CD8(-) thymocytes, strongly expressed in CD4(+) CD8(+) thymocytes, while expression decreases in more mature cells. The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization (By similarity). SLA deficient mice show a strong up-regulation of TCR and CD5 at the CD4(+) CD8(+) stage, and an enhanced positive selection in T-cells. non-membrane spanning protein tyrosine kinase activity SH3/SH2 adaptor activity receptor binding protein binding cytoplasm endosome transmembrane receptor protein tyrosine kinase signaling pathway regulation of signal transduction positive regulation of signal transduction cell differentiation extrinsic component of cytoplasmic side of plasma membrane peptidyl-tyrosine autophosphorylation regulation of cell proliferation uc007was.1 uc007was.2 uc007was.3 uc007was.4 
ENSMUST00000164172.8 Elf5 ENSMUST00000164172.8 E74-like factor 5, transcript variant 2 (from RefSeq NM_001145813.1) ELF5_MOUSE ENSMUST00000164172.1 ENSMUST00000164172.2 ENSMUST00000164172.3 ENSMUST00000164172.4 ENSMUST00000164172.5 ENSMUST00000164172.6 ENSMUST00000164172.7 NM_001145813 Q8VDK3 Q921H5 Q9Z2K6 uc012cah.1 uc012cah.2 uc012cah.3 uc012cah.4 Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation (By similarity). Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter. Nucleus Expressed in lung, kidney, stomach, brain, ovaries, tongue, bladder and mammary glands. In the neonatal stage, and during embryogenesis on days 16, 17 and 19, an expression pattern similar to the adult was observed. In addition at stage 16, expression was detected in small intestine. The PNT domain acts as a transcriptional activator. Belongs to the ETS family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ectodermal cell fate commitment DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter ectoderm development cell differentiation somatic stem cell population maintenance sequence-specific DNA binding negative regulation of cell differentiation positive regulation of transcription from RNA polymerase II promoter mammary gland epithelial cell differentiation uc012cah.1 uc012cah.2 uc012cah.3 uc012cah.4 
ENSMUST00000164181.2 Myl6 ENSMUST00000164181.2 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle, transcript variant 3 (from RefSeq NM_010860.4) ENSMUST00000164181.1 Myl6 NM_010860 Q642K0 Q642K0_MOUSE uc007hnc.1 uc007hnc.2 uc007hnc.3 uc007hnc.4 calcium ion binding brush border structural constituent of muscle uc007hnc.1 uc007hnc.2 uc007hnc.3 uc007hnc.4 
ENSMUST00000164186.8 Nol4 ENSMUST00000164186.8 nucleolar protein 4, transcript variant 3 (from RefSeq NM_001347509.1) E9Q947 E9Q947_MOUSE ENSMUST00000164186.1 ENSMUST00000164186.2 ENSMUST00000164186.3 ENSMUST00000164186.4 ENSMUST00000164186.5 ENSMUST00000164186.6 ENSMUST00000164186.7 NM_001347509 Nol4 uc057kzi.1 uc057kzi.2 uc057kzi.3 nucleolus uc057kzi.1 uc057kzi.2 uc057kzi.3 
ENSMUST00000164192.9 Rasgrp3 ENSMUST00000164192.9 RAS, guanyl releasing protein 3 (from RefSeq NM_001411230.1) ENSMUST00000164192.1 ENSMUST00000164192.2 ENSMUST00000164192.3 ENSMUST00000164192.4 ENSMUST00000164192.5 ENSMUST00000164192.6 ENSMUST00000164192.7 ENSMUST00000164192.8 NM_001411230 Q6NZH9 Q6NZH9_MOUSE Rasgrp3 uc012axi.1 uc012axi.2 uc012axi.3 uc012axi.4 Cytoplasm, cytosol Belongs to the RASGRP family. guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity GTPase activator activity calcium ion binding cytoplasm small GTPase mediated signal transduction Ras protein signal transduction Ras GTPase binding kinase binding guanyl-nucleotide exchange factor complex intracellular signal transduction regulation of GTPase activity positive regulation of GTPase activity metal ion binding perinuclear region of cytoplasm uc012axi.1 uc012axi.2 uc012axi.3 uc012axi.4 
ENSMUST00000164202.9 Rbm20 ENSMUST00000164202.9 RNA binding motif protein 20 (from RefSeq NM_001170847.1) E9PVK0 ENSMUST00000164202.1 ENSMUST00000164202.2 ENSMUST00000164202.3 ENSMUST00000164202.4 ENSMUST00000164202.5 ENSMUST00000164202.6 ENSMUST00000164202.7 ENSMUST00000164202.8 NM_001170847 Q3UQS8 Q8CFS9 RBM20_MOUSE Rbm20 uc008hwz.1 uc008hwz.2 uc008hwz.3 uc008hwz.4 RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24584570, PubMed:27630136, PubMed:29650543, PubMed:29895960, PubMed:33110103, PubMed:35394688, PubMed:35041844). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre- mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:32187365). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27630136, PubMed:29895960, PubMed:33110103, PubMed:35041844). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:37272356). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). Associates with components of the U1 and U2 U1 small nuclear ribonucleoprotein complexes. Nucleus toplasm, Cytoplasmic ribonucleoprotein granule Note=The active form that regulates alternative splicing localizes to the nucleus (PubMed:35394688). Also localizes to cytoplasmic ribonucleoprotein granules; localization to cytoplasmic ribonucleoprotein granules plays an important regulatory role (PubMed:35394688). Subcellular localization is regulated by phosphorylation of different parts of the protein: while phosphorylation of the RS (arginine/serine-rich) region promotes nuclear localization, phosphorylation of the C-terminal disordered region promotes localization to cytoplasmic ribonucleoprotein granules (PubMed:29895960, PubMed:35394688). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UQS8-1; Sequence=Displayed; Name=2; IsoId=Q3UQS8-2; Sequence=VSP_044393; Predominantly expressed in striated muscle, with highest expression in the heart (PubMed:22466703, PubMed:23886709). In differentiating myoblasts, expression correlates with sarcomere assembly: expression peaks when alpha-actinin is localized mainly in mature Z bodies within the nascent myofiber and expression declines as the sarcomeres continue to mature (PubMed:22466703). Also expressed in kidney (PubMed:23886709). During early embryonic cardiogenesis. Phosphorylation regulates the subcellular localization. Phosphorylation of Ser-637 and Ser-639 in the RS (arginine/serine-rich) region promotes nuclear localization of the protein (PubMed:29895960, PubMed:35394688). In contrast, phosphorylation of the C-terminal disordered region promotes localization to cytoplasmic ribonucleoprotein granules (By similarity). Mice were born in normal Mendelian ratios, are viable, and do not exhibit any visible phenotype (PubMed:29650543). They however develop cardiomyopathy and display splicing defects in genes related to calcium handling such as CAMK2D or RYR2 (PubMed:29650543). Sequence=AAH38663.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleic acid binding RNA binding nucleus mRNA processing heart development zinc ion binding RNA splicing positive regulation of RNA splicing regulation of RNA splicing uc008hwz.1 uc008hwz.2 uc008hwz.3 uc008hwz.4 
ENSMUST00000164207.10 Fgfr3 ENSMUST00000164207.10 fibroblast growth factor receptor 3, transcript variant 6 (from RefSeq NM_001359036.1) ENSMUST00000164207.1 ENSMUST00000164207.2 ENSMUST00000164207.3 ENSMUST00000164207.4 ENSMUST00000164207.5 ENSMUST00000164207.6 ENSMUST00000164207.7 ENSMUST00000164207.8 ENSMUST00000164207.9 F6TK14 F6TK14_MOUSE Fgfr3 NM_001359036 uc008xbf.1 uc008xbf.2 uc008xbf.3 uc008xbf.4 uc008xbf.5 This gene encodes a member of the fibroblast growth factor receptor family. Members of this family are highly conserved proteins that differ from one another in their ligand affinities and tissue distribution. A representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene may be associated with craniosynostosis and multiple types of skeletal dysplasia. A pseudogene of this gene is located on chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence= Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor-activated receptor activity ATP binding nucleus cytoplasm endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane protein phosphorylation cell-cell signaling positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway cell surface positive regulation of phospholipase activity membrane integral component of membrane kinase activity phosphorylation transferase activity fibroblast growth factor binding peptidyl-tyrosine phosphorylation transport vesicle positive regulation of tyrosine phosphorylation of STAT protein identical protein binding positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity protein autophosphorylation positive regulation of ERK1 and ERK2 cascade fibroblast growth factor receptor apoptotic signaling pathway uc008xbf.1 uc008xbf.2 uc008xbf.3 uc008xbf.4 uc008xbf.5 
ENSMUST00000164216.6 Spmip2 ENSMUST00000164216.6 sperm microtubule inner protein 2, transcript variant 2 (from RefSeq NM_001142953.2) E9QAV2 E9QAV2_MOUSE ENSMUST00000164216.1 ENSMUST00000164216.2 ENSMUST00000164216.3 ENSMUST00000164216.4 ENSMUST00000164216.5 Gm17359 NM_001142953 Spmip2 uc012cqo.1 uc012cqo.2 uc012cqo.3 uc012cqo.1 uc012cqo.2 uc012cqo.3 
ENSMUST00000164225.6 Med12l ENSMUST00000164225.6 May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (from UniProt Q8BQM9) AK129412 ENSMUST00000164225.1 ENSMUST00000164225.2 ENSMUST00000164225.3 ENSMUST00000164225.4 ENSMUST00000164225.5 Kiaa3007 MD12L_MOUSE Q6ZPF2 Q8BQM9 Q8C9E3 uc290fmg.1 uc290fmg.2 May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). May be a component of the Mediator complex, which is known to be composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BQM9-1; Sequence=Displayed; Name=2; IsoId=Q8BQM9-2; Sequence=VSP_029999; Name=3; IsoId=Q8BQM9-3; Sequence=VSP_029998, VSP_030000, VSP_030003; Name=4; IsoId=Q8BQM9-4; Sequence=VSP_029998, VSP_030001, VSP_030002; Belongs to the Mediator complex subunit 12 family. Sequence=BAC98285.1; Type=Erroneous initiation; Evidence=; transcription cofactor activity transcription coactivator activity nucleus regulation of transcription from RNA polymerase II promoter beta-catenin binding transcription factor binding mediator complex positive regulation of nucleic acid-templated transcription uc290fmg.1 uc290fmg.2 
ENSMUST00000164227.4 Vmn2r87 ENSMUST00000164227.4 vomeronasal 2, receptor 87 (from RefSeq NM_001103366.1) E9PZX4 E9PZX4_MOUSE ENSMUST00000164227.1 ENSMUST00000164227.2 ENSMUST00000164227.3 NM_001103366 Vmn2r87 uc009vae.1 uc009vae.2 uc009vae.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vae.1 uc009vae.2 uc009vae.3 
ENSMUST00000164233.8 Dnaja1 ENSMUST00000164233.8 DnaJ heat shock protein family (Hsp40) member A1, transcript variant 3 (from RefSeq NM_001164672.2) Dnaja1 ENSMUST00000164233.1 ENSMUST00000164233.2 ENSMUST00000164233.3 ENSMUST00000164233.4 ENSMUST00000164233.5 ENSMUST00000164233.6 ENSMUST00000164233.7 NM_001164672 Q5NTY0 Q5NTY0_MOUSE uc012dbx.1 uc012dbx.2 uc012dbx.3 uc012dbx.4 The protein encoded by this gene is a member of the DnaJ family, whose members act as cochaperones of heat shock protein 70. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. Mice deficient for this gene display reduced levels of activation&#8208;induced deaminase, an enzyme that deaminates deoxycytidine at the immunoglobulin genes during immune responses. In addition, mice lacking this gene exhibit severe defects in spermatogenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Cytoplasm, perinuclear region Membrane ; Lipid-anchor Microsome Mitochondrion Nucleus G-protein coupled receptor binding ATPase activator activity ATP binding cytosol protein folding response to heat microtubule cytoskeleton membrane Hsp70 protein binding Tat protein binding heat shock protein binding negative regulation of protein ubiquitination ubiquitin protein ligase binding positive regulation of ATPase activity DNA damage response, detection of DNA damage positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of JUN kinase activity metal ion binding low-density lipoprotein particle receptor binding unfolded protein binding chaperone binding regulation of protein transport C3HC4-type RING finger domain binding protein localization to mitochondrion negative regulation of establishment of protein localization to mitochondrion negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway uc012dbx.1 uc012dbx.2 uc012dbx.3 uc012dbx.4 
ENSMUST00000164245.2 Vmn1r101 ENSMUST00000164245.2 vomeronasal 1 receptor 101 (from RefSeq NM_001166836.1) E9Q365 E9Q365_MOUSE ENSMUST00000164245.1 NM_001166836 Vmn1r101 uc012fby.1 uc012fby.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fby.1 uc012fby.2 
ENSMUST00000164262.9 Speer1d ENSMUST00000164262.9 Speer1d (from geneSymbol) ENSMUST00000164262.1 ENSMUST00000164262.2 ENSMUST00000164262.3 ENSMUST00000164262.4 ENSMUST00000164262.5 ENSMUST00000164262.6 ENSMUST00000164262.7 ENSMUST00000164262.8 Gm8890 L7N284 L7N284_MOUSE uc290tdg.1 uc290tdg.2 uc290tdg.3 uc290tdg.1 uc290tdg.2 uc290tdg.3 
ENSMUST00000164267.3 Hcar1 ENSMUST00000164267.3 hydrocarboxylic acid receptor 1 (from RefSeq NM_175520.5) B9EJ36 ENSMUST00000164267.1 ENSMUST00000164267.2 Gpr81 HCAR1_MOUSE NM_175520 Q8C131 uc008zoq.1 uc008zoq.2 uc008zoq.3 uc008zoq.4 Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway. Cell membrane; Multi-pass membrane protein. Highly expressed in subcutaneous fat and omental fat and detectable in lower levels in brain and many other tissues. High levels detected in epididymal and subcutaneous fat with slightly lower in omental fat, low levels are detected in the brain, skeletal muscle, kidney, liver and the pancreas (at protein level). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane intracellular organelle negative regulation of lipid catabolic process uc008zoq.1 uc008zoq.2 uc008zoq.3 uc008zoq.4 
ENSMUST00000164273.9 Panx1 ENSMUST00000164273.9 pannexin 1 (from RefSeq NM_019482.2) ENSMUST00000164273.1 ENSMUST00000164273.2 ENSMUST00000164273.3 ENSMUST00000164273.4 ENSMUST00000164273.5 ENSMUST00000164273.6 ENSMUST00000164273.7 ENSMUST00000164273.8 NM_019482 PANX1_MOUSE Panx1 Q5RL18 Q9CXS7 Q9JIP4 uc009ofi.1 uc009ofi.2 uc009ofi.3 Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (By similarity). Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Plays a critical role in oogenesis. Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes. Q9JIP4; P97382: Kcnab3; NbExp=2; IntAct=EBI-6272917, EBI-7261133; Cell membrane ; Multi-pass membrane protein Cell junction, gap junction Endoplasmic reticulum membrane ; Multi-pass membrane protein Widely expressed, including in cartilage, skin, spleen and brain. S-nitrosylation inhibits channel currents and ATP release. N-glycosylation may play a role in cell surface targeting (PubMed:17925379). Exists in three glycosylation states: non- glycosylated (GLY0), high-mannose glycosylated (GLY1), and fully mature glycosylated (GLY2) (By similarity). Belongs to the pannexin family. protease binding response to ischemia actin binding receptor binding gap junction channel activity calcium channel activity protein binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane gap junction ion transport cation transport calcium ion transport cell-cell signaling channel activity membrane integral component of membrane wide pore channel activity leak channel activity cell junction bleb macromolecular complex response to ATP protein hexamerization ion channel binding protein heterodimerization activity positive regulation of cytokine secretion positive regulation of interleukin-1 secretion positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion actin filament binding gap junction hemi-channel activity transmembrane transport calcium ion transmembrane transport scaffold protein binding uc009ofi.1 uc009ofi.2 uc009ofi.3 
ENSMUST00000164288.2 Vmn1r116 ENSMUST00000164288.2 vomeronasal 1 receptor 116 (from RefSeq NM_001166744.1) ENSMUST00000164288.1 L7N2A6 L7N2A6_MOUSE NM_001166744 Vmn1r116 uc012fcq.1 uc012fcq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fcq.1 uc012fcq.2 
ENSMUST00000164297.8 Skint11 ENSMUST00000164297.8 selection and upkeep of intraepithelial T cells 11, transcript variant 1 (from RefSeq NM_001166027.1) A7XV14 ENSMUST00000164297.1 ENSMUST00000164297.2 ENSMUST00000164297.3 ENSMUST00000164297.4 ENSMUST00000164297.5 ENSMUST00000164297.6 ENSMUST00000164297.7 NM_001166027 SKI11_MOUSE uc012div.1 uc012div.2 May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. Membrane ; Multi-pass membrane protein Expressed in skin and thymus. Encoded by one of the 11 copies of Skint genes clustered in the D1 region of the chromosome 4. Belongs to the SKINT family. receptor binding external side of plasma membrane membrane integral component of membrane regulation of immune response T cell receptor signaling pathway uc012div.1 uc012div.2 
ENSMUST00000164309.3 Mcm5 ENSMUST00000164309.3 minichromosome maintenance complex component 5, transcript variant 1 (from RefSeq NM_008566.3) Cdc46 ENSMUST00000164309.1 ENSMUST00000164309.2 MCM5_MOUSE Mcm5 Mcmd5 NM_008566 P49718 Q52KC3 uc009mhd.1 uc009mhd.2 uc009mhd.3 uc009mhd.4 The protein encoded by this gene is a member of the oligameric minichromosome maintenance protein complex. During DNA replication, the complex loads onto chromatin in early G1 and is converted into an active replicative helicase during S phase. It functions to limit DNA synthesis to once per cell cycle. During embryogenesis, the encoded protein is negatively regulated through expression of paired box protein Pax 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7- MCM3-MCM5. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex. Interacts with ANKRD17. Interacts with MCMBP. Interacts with TONSL; the interaction is direct. Nucleus Chromosome Cytoplasm, cytosol Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. Belongs to the MCM family. Sequence=BAA05083.1; Type=Frameshift; Evidence=; nucleotide binding double-strand break repair via break-induced replication DNA binding DNA helicase activity DNA replication origin binding single-stranded DNA binding helicase activity ATP binding nucleus nucleoplasm cytoplasm cytosol DNA replication pre-replicative complex assembly involved in nuclear cell cycle DNA replication DNA replication initiation cell cycle hydrolase activity DNA duplex unwinding MCM complex single-stranded DNA-dependent ATP-dependent DNA helicase activity 3'-5' DNA helicase activity uc009mhd.1 uc009mhd.2 uc009mhd.3 uc009mhd.4 
ENSMUST00000164372.3 Gm2244 ENSMUST00000164372.3 Gm2244 (from geneSymbol) ENSMUST00000164372.1 ENSMUST00000164372.2 Gm2244 L7N2A3 L7N2A3_MOUSE uc288rdw.1 uc288rdw.2 molecular_function cellular_component biological_process uc288rdw.1 uc288rdw.2 
ENSMUST00000164375.4 Zyx ENSMUST00000164375.4 zyxin, transcript variant 2 (from RefSeq NM_001289617.2) ENSMUST00000164375.1 ENSMUST00000164375.2 ENSMUST00000164375.3 NM_001289617 P70461 Q3UGQ3 Q62523 ZYX_MOUSE uc009brb.1 uc009brb.2 uc009brb.3 uc009brb.4 Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion- stimulated changes in gene expression (By similarity). Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with SYNPO2 (By similarity). Cytoplasm Cytoplasm, cytoskeleton Cell junction, focal adhesion Nucleus Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1 (By similarity). Belongs to the zyxin/ajuba family. stress fiber protein binding nucleus cytoplasm cytosol cytoskeleton cell-cell adherens junction focal adhesion cell adhesion cell-matrix adhesion signal transduction transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway cell junction stress fiber assembly phagocytic vesicle metal ion binding regulation of inflammatory response cellular response to interferon-gamma uc009brb.1 uc009brb.2 uc009brb.3 uc009brb.4 
ENSMUST00000164379.2 Gm17203 ENSMUST00000164379.2 Gm17203 (from geneSymbol) ENSMUST00000164379.1 KY467829 uc057lbf.1 uc057lbf.2 uc057lbf.1 uc057lbf.2 
ENSMUST00000164397.8 B3gnt5 ENSMUST00000164397.8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5, transcript variant 1 (from RefSeq NM_001159407.1) B3GN5_MOUSE B3gnt5 ENSMUST00000164397.1 ENSMUST00000164397.2 ENSMUST00000164397.3 ENSMUST00000164397.4 ENSMUST00000164397.5 ENSMUST00000164397.6 ENSMUST00000164397.7 NM_001159407 Q810C6 Q8BGY6 Q923K7 uc012acn.1 uc012acn.2 Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development. Reaction=a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N- acetyl-alpha-D-glucosamine = a beta-D-GlcNAc-(1->3)-beta-D-Gal- (1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:13905, ChEBI:CHEBI:15378, ChEBI:CHEBI:17103, ChEBI:CHEBI:17950, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223; EC=2.4.1.206; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13906; Evidence=; Reaction=a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D- glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP; Xref=Rhea:RHEA:23004, ChEBI:CHEBI:15378, ChEBI:CHEBI:17006, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:142448; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23005; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Highly expressed in adult spleen, placenta and cerebellar Purkinje cells where it colocalizes with HNK-1. Expressed at lower level in brain, lung, thymus and muscle. Mainly expressed during embryonic development. Expressed in most tissues at embryonic day 11 with elevated expression in the developing central nervous system. Belongs to the glycosyltransferase 31 family. Golgi membrane endoplasmic reticulum Golgi apparatus protein glycosylation protein O-linked glycosylation multicellular organism development central nervous system development brain development acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups sphingolipid biosynthetic process poly-N-acetyllactosamine biosynthetic process lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity uc012acn.1 uc012acn.2 
ENSMUST00000164399.8 Pkig ENSMUST00000164399.8 protein kinase inhibitor, gamma, transcript variant 15 (from RefSeq NM_001420668.1) ENSMUST00000164399.1 ENSMUST00000164399.2 ENSMUST00000164399.3 ENSMUST00000164399.4 ENSMUST00000164399.5 ENSMUST00000164399.6 ENSMUST00000164399.7 NM_001420668 Pkig Q3TP50 Q3TP50_MOUSE uc008nth.1 uc008nth.2 uc008nth.3 Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Belongs to the PKI family. protein kinase inhibitor activity cAMP-dependent protein kinase inhibitor activity negative regulation of protein kinase activity signal transduction negative regulation of protein serine/threonine kinase activity uc008nth.1 uc008nth.2 uc008nth.3 
ENSMUST00000164409.2 Vmn1r122 ENSMUST00000164409.2 vomeronasal 1 receptor 122 (from RefSeq NM_001166714.1) ENSMUST00000164409.1 K7N726 K7N726_MOUSE NM_001166714 Vmn1r122 uc012fcw.1 uc012fcw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fcw.1 uc012fcw.2 
ENSMUST00000164411.10 Ccr6 ENSMUST00000164411.10 C-C motif chemokine receptor 6, transcript variant 2 (from RefSeq NM_001190333.1) Ccr6 ENSMUST00000164411.1 ENSMUST00000164411.2 ENSMUST00000164411.3 ENSMUST00000164411.4 ENSMUST00000164411.5 ENSMUST00000164411.6 ENSMUST00000164411.7 ENSMUST00000164411.8 ENSMUST00000164411.9 NM_001190333 Q542B6 Q542B6_MOUSE uc008ajd.1 uc008ajd.2 uc008ajd.3 uc008ajd.4 uc008ajd.5 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity chemokine receptor activity chemotaxis immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell surface positive regulation of epithelial cell migration membrane integral component of membrane C-C chemokine receptor activity calcium-mediated signaling C-C chemokine binding sperm flagellum cell chemotaxis positive regulation of flagellated sperm motility involved in capacitation chemokine-mediated signaling pathway sperm midpiece sperm principal piece sperm plasma membrane positive regulation of dendritic cell chemotaxis uc008ajd.1 uc008ajd.2 uc008ajd.3 uc008ajd.4 uc008ajd.5 
ENSMUST00000164416.8 Pcid2 ENSMUST00000164416.8 PCI domain containing 2 (from RefSeq NM_178708.3) ENSMUST00000164416.1 ENSMUST00000164416.2 ENSMUST00000164416.3 ENSMUST00000164416.4 ENSMUST00000164416.5 ENSMUST00000164416.6 ENSMUST00000164416.7 NM_178708 PCID2_MOUSE Q147Z6 Q8BFV2 Q8C951 uc033jek.1 uc033jek.2 uc033jek.3 Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (PubMed:20870947). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (By similarity). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (PubMed:29138493). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (PubMed:29138493). Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, 2 copies of ENY2, PCID2, SEM1/DSS1, and either centrin CETN2 or centrin CETN3. The TREX-2 complex also associates with ALYREF/ALY and with the nucleoporin NUP153 (By similarity). Interacts with BRCA2 (By similarity). Interacts with SRCAP chromatin remodeling complex component ZNHIT1; the interaction results in inhibition of SRCAP complex activity, preventing the deposition of histone variant H2AZ1/H2A.Z to lymphoid fate regulator genes and restricting lymphoid lineage commitment (PubMed:29138493). Cytoplasm Nucleus, nuclear pore complex Highly expressed in bone marrow and haematopoietic progenitor cells but is almost undetectable in mature blood cells. In B lineage cells, expressed in a stage-dependent manner at high levels in bone marrow pre-B and immature B-cells, and in spleen transitional 1 and follicular B-cells, but at lower levels in pro-B, transitional 2, and marginal zone B-cells. Conditional knockout in bone marrow increases lymphoid cell numbers but decreases the number of myeloid cells (PubMed:29138493). Decreased bone marrow cellularity, enlargement of thymus and cervical lymph nodes with an increased number of lymphocytes, increased lymphocyte numbers in peripheral blood, decreased numbers of granulocytes and monocytes, enrichment of transcription factor Spi1/PU.1 at the promoters of lymphoid fate regulator genes, increased expression of lymphoid fate regulator genes, and enhanced lymphoid differentiation of hematopoietic multipotent progenitor cells (PubMed:29138493). No effect on red blood cell or platelet numbers (PubMed:29138493). Belongs to the CSN12 family. posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery double-stranded DNA binding RNA binding cellular_component nucleus cytoplasm transcription elongation from RNA polymerase II promoter poly(A)+ mRNA export from nucleus negative regulation of apoptotic process regulation of mRNA stability nuclear pore nuclear basket positive regulation of B cell differentiation positive regulation of transcription, DNA-templated spleen development transcription export complex 2 nuclear retention of pre-mRNA at the site of transcription positive regulation of mitotic cell cycle spindle assembly checkpoint negative regulation of cysteine-type endopeptidase activity transcriptionally active chromatin uc033jek.1 uc033jek.2 uc033jek.3 
ENSMUST00000164422.2 Gm4884 ENSMUST00000164422.2 predicted gene 4884 (from RefSeq NM_183166.2) E9PVP9 E9PVP9_MOUSE ENSMUST00000164422.1 Gm4884 NM_183166 uc009glj.1 uc009glj.2 molecular_function cellular_component biological_process uc009glj.1 uc009glj.2 
ENSMUST00000164428.3 Gm17455 ENSMUST00000164428.3 predicted gene, 17455, transcript variant 3 (from RefSeq NM_001399671.1) ENSMUST00000164428.1 ENSMUST00000164428.2 G3UW87 G3UW87_MOUSE Gm17455 NM_001399671 uc011xej.1 uc011xej.2 uc011xej.3 membrane integral component of membrane uc011xej.1 uc011xej.2 uc011xej.3 
ENSMUST00000164454.3 Serpina1b ENSMUST00000164454.3 Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. (from UniProt P22599) A1AT2_MOUSE Aat2 BC106098 Dom2 ENSMUST00000164454.1 ENSMUST00000164454.2 P22599 Q61283 Q80ZH5 Q8VC20 Spi1-2 uc288iwd.1 uc288iwd.2 Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Secreted The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin- protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity. Murine alpha-1-antitrypsin is represented by a cluster of up to 6 individual Serpina1-related genes. The precise complement of Serpina1-related genes present varies according to the strain of the animal. Belongs to the serpin family. in utero embryonic development protease binding endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity protein binding extracellular region extracellular space endoplasmic reticulum Golgi apparatus protein N-linked glycosylation acute-phase response negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to cytokine identical protein binding intracellular membrane-bounded organelle response to peptide hormone uc288iwd.1 uc288iwd.2 
ENSMUST00000164462.3 Vmn2r79 ENSMUST00000164462.3 vomeronasal 2, receptor 79 (from RefSeq NM_001105190.1) E9PXH8 E9Q067 E9Q067_MOUSE ENSMUST00000164462.1 ENSMUST00000164462.2 NM_001105190 Vmn2r79 uc012fos.1 uc012fos.2 uc012fos.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012fos.1 uc012fos.2 uc012fos.3 
ENSMUST00000164465.3 Omg ENSMUST00000164465.3 oligodendrocyte myelin glycoprotein (from RefSeq NM_019409.2) ENSMUST00000164465.1 ENSMUST00000164465.2 G3XA53 G3XA53_MOUSE NM_019409 Omg uc007kkn.1 uc007kkn.2 uc007kkn.3 uc007kkn.4 uc007kkn.1 uc007kkn.2 uc007kkn.3 uc007kkn.4 
ENSMUST00000164471.8 Scpppq1 ENSMUST00000164471.8 secretory calcium-binding phosphoprotein proline-glutamine rich 1 (from RefSeq NM_001163772.1) B9UIU9 ENSMUST00000164471.1 ENSMUST00000164471.2 ENSMUST00000164471.3 ENSMUST00000164471.4 ENSMUST00000164471.5 ENSMUST00000164471.6 ENSMUST00000164471.7 Gm17660 NM_001163772 SCPPQ_MOUSE Scpppq1 uc012dzy.1 uc012dzy.2 uc012dzy.3 uc012dzy.4 Tooth-associated epithelia protein that may participate in structuring the basal lamina at cell-tooth interface. Secreted Note=Localizes at the cell-tooth interface with AMTN and ODAM. Expressed in enamel organ. uc012dzy.1 uc012dzy.2 uc012dzy.3 uc012dzy.4 
ENSMUST00000164472.8 Zfp637 ENSMUST00000164472.8 zinc finger protein 637, transcript variant 5 (from RefSeq NM_177684.4) ENSMUST00000164472.1 ENSMUST00000164472.2 ENSMUST00000164472.3 ENSMUST00000164472.4 ENSMUST00000164472.5 ENSMUST00000164472.6 ENSMUST00000164472.7 NM_177684 Q3UIS3 Q80V23 ZNF32_MOUSE Znf32 uc009dky.1 uc009dky.2 uc009dky.3 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80V23-1; Sequence=Displayed; Name=2; IsoId=Q80V23-2; Sequence=VSP_016954; Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding nucleus biological_process metal ion binding uc009dky.1 uc009dky.2 uc009dky.3 
ENSMUST00000164479.9 Stard10 ENSMUST00000164479.9 Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes (By similarity). May play metabolic roles in sperm maturation or fertilization. (from UniProt Q9JMD3) AB031550 ENSMUST00000164479.1 ENSMUST00000164479.2 ENSMUST00000164479.3 ENSMUST00000164479.4 ENSMUST00000164479.5 ENSMUST00000164479.6 ENSMUST00000164479.7 ENSMUST00000164479.8 Pctpl Q9JMD3 STA10_MOUSE Sdccag28 Sdccagg28 uc291tgf.1 uc291tgf.2 Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes (By similarity). May play metabolic roles in sperm maturation or fertilization. Cell projection, cilium, flagellum Cytoplasm Membrane Note=Mainly cytosolic (By similarity). In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm. Testis, kidney, liver, and intestine with the highest level in the testis. During male germ cell development, it was detected first in the 23-day-old mouse testis, and the signal increased with age. Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association. cytoplasm cytosol microvillus cilium lipid transport lipid binding membrane motile cilium bile acid secretion positive regulation of peroxisome proliferator activated receptor signaling pathway cell projection intercellular canaliculus uc291tgf.1 uc291tgf.2 
ENSMUST00000164491.3 Mdfic2 ENSMUST00000164491.3 MyoD family inhibitor domain containing 2 (from RefSeq NM_001128092.1) B2RVL9 B2RVL9_MOUSE ENSMUST00000164491.1 ENSMUST00000164491.2 Gm765 Mdfic2 NM_001128092 uc012epp.1 uc012epp.2 uc012epp.3 Belongs to the MDFI family. molecular_function cellular_component biological_process uc012epp.1 uc012epp.2 uc012epp.3 
ENSMUST00000164502.3 Muc21 ENSMUST00000164502.3 mucin 21 (from RefSeq NM_001244654.1) ENSMUST00000164502.1 ENSMUST00000164502.2 F7C950 F7C950_MOUSE Gm9573 Muc21 NM_001244654 uc012arn.1 uc012arn.2 uc012arn.3 molecular_function plasma membrane negative regulation of cell adhesion negative regulation of cell-substrate adhesion membrane integral component of membrane negative regulation of cell-cell adhesion uc012arn.1 uc012arn.2 uc012arn.3 
ENSMUST00000164512.8 Gm2974 ENSMUST00000164512.8 Gm2974 (from geneSymbol) CT010181 ENSMUST00000164512.1 ENSMUST00000164512.2 ENSMUST00000164512.3 ENSMUST00000164512.4 ENSMUST00000164512.5 ENSMUST00000164512.6 ENSMUST00000164512.7 Gm2974 L7N2C2 L7N2C2_MOUSE uc288qjd.1 uc288qjd.2 molecular_function cellular_component biological_process uc288qjd.1 uc288qjd.2 
ENSMUST00000164517.3 Eif1ad19 ENSMUST00000164517.3 eukaryotic translation initiation factor 1A domain containing 19 (from RefSeq NM_001270722.1) ENSMUST00000164517.1 ENSMUST00000164517.2 Eif1ad19 F6YNI8 F6YNI8_MOUSE NM_001270722 uc033gem.1 uc033gem.2 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. RNA binding translation initiation factor activity translation translational initiation uc033gem.1 uc033gem.2 
ENSMUST00000164518.4 4933411K16Rik ENSMUST00000164518.4 RIKEN cDNA 4933411K16 gene (from RefSeq NM_025752.2) CJ062_MOUSE ENSMUST00000164518.1 ENSMUST00000164518.2 ENSMUST00000164518.3 NM_025752 Q80Y39 uc008hnc.1 uc008hnc.2 uc008hnc.3 uc008hnc.4 molecular_function cellular_component biological_process uc008hnc.1 uc008hnc.2 uc008hnc.3 uc008hnc.4 
ENSMUST00000164526.2 Vmn1r94 ENSMUST00000164526.2 vomeronasal 1 receptor 94 (from RefSeq NM_001166723.1) ENSMUST00000164526.1 K7N6X3 K7N6X3_MOUSE NM_001166723 Vmn1r94 uc012fbq.1 uc012fbq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fbq.1 uc012fbq.2 
ENSMUST00000164537.2 Vmn1r163 ENSMUST00000164537.2 vomeronasal 1 receptor 163 (from RefSeq NM_001166755.1) ENSMUST00000164537.1 K9J7G0 K9J7G0_MOUSE NM_001166755 Vmn1r135 Vmn1r163 uc012feo.1 uc012feo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012feo.1 uc012feo.2 
ENSMUST00000164538.2 Otog ENSMUST00000164538.2 otogelin (from RefSeq NM_013624.2) E9QMN3 ENSMUST00000164538.1 G3UWC8 NM_013624 O55225 OTOG_MOUSE Otgn Q3TMP0 uc009gyk.1 uc009gyk.2 uc009gyk.3 Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes. Apical cell membrane ; Peripheral membrane protein xtracellular side Secreted, extracellular space Note=Found in fiber- like structures during the maturation process of the tectorial membrane (PubMed:9405633). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O55225-1; Sequence=Displayed; Name=2; IsoId=O55225-2; Sequence=VSP_029715, VSP_029716; Expressed specifically in neuroepithelial supporting cells of the inner ear. Expressed in the cochlea between postnatal day P0 and P6 in pseudostratified cells of the greater epithelial ridge, in supporting cells of the neuroepithelium comprising Deiter's, Hensen's, pillar and Claudius cells, in epithelial cells of the Reissner's membrane, in a small set of cells comprising the spiral prominence. Expressed in the cochlea at P15 in interdental cells located underneath the limbal part of the tectorial membrane. Expressed in the vestibular apparatus at P0 in supporting cells of the saccular, utricular maculae and cristae ampullares, in the epithelial cells of the roof of the saccule but not in the roof of the utricle and cristae ampullares (at protein level). Expressed in the cochlea and vestibular organ of the inner ear. Expressed in the epithelial cells of the otic vesicle at 10 dpc. Expressed in non-sensory cells of the developing vestibule, in the transitory epithelium of the saccule, utricle and cristae ampullares, in epithelial cells of the roof of the saccule, but not the roof of the utricle nor the cristae ampullares at 13 dpc. Expressed in supporting cells of the vestibular maculae at 13 dpc onward birth. Expressed in non-sensory cells of the emerging cochlear duct at 12 dpc. Expressed in the pluristratified sensory epithelium as well as in the epithelium of the roof at 14 dpc. Expressed in the developing sensory epithelium (the spiral limbus, the greater epithelial ridge and the lesser epithelial ridge) of the cochlear duct, the interdental cells of the spiral limbus and in the columnar cells that form the greater epithelial ridge at 16 and 17 dpc. Expressed in the non-sensory pillar, Deiter's and Hensen's cells of the organ of Corti and Claudius cells at 19 dpc onward birth (at protein level). N-glycosylated. Not O-glycosylated. Impaired vestibular and auditory functions. Belongs to the otogelin family. structural molecule activity extracellular region extracellular space cytosol plasma membrane sensory perception of sound adult locomotory behavior membrane apical plasma membrane extracellular matrix L-arabinose metabolic process alpha-L-arabinofuranosidase activity uc009gyk.1 uc009gyk.2 uc009gyk.3 
ENSMUST00000164539.2 Spag17 ENSMUST00000164539.2 sperm associated antigen 17 (from RefSeq NM_028892.4) ENSMUST00000164539.1 G3UYF7 NM_028892 Q3UWG8 Q5S003 Q6Q758 Q8CDR5 Q9CUE5 SPG17_MOUSE uc012cus.1 uc012cus.2 Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia (PubMed:23418344, PubMed:15827353). May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts (PubMed:26017218). Essential for normal spermatogenesis and male fertility (PubMed:29690537). Required for normal manchette structure, transport of proteins along the manchette microtubules and formation of the sperm head and flagellum (PubMed:29690537). Essential for sperm flagellum development and proper assembly of the respiratory motile cilia central pair apparatus, but not the brain ependymal cilia (PubMed:32988999). Interacts (via the C-terminus) with SPAG6; the interaction probably occurs on polymerized microtubules. Q5S003; Q9JLI7: Spag6; NbExp=3; IntAct=EBI-1783665, EBI-1783654; Cytoplasm toplasm, cytoskeleton, flagellum axoneme Cytoplasmic vesicle, secretory vesicle, acrosome Golgi apparatus Cytoplasm, cytoskeleton Note=Detected in the cytoplasm of round spermatids and in condensing spermatids. Localized to the central pair of the sperm flagellar axoneme. Colocalizes with SPAG6 on microtubules. Localizes to the manchette in elongating spermatids (PubMed:29690537). Highly expressed in testis, round spermatids, testicular sperm, epididymal sperm and in condensing spermatids (at protein level) (PubMed:15827353, PubMed:29690537, PubMed:32988999). Expressed in organs that contain cilia-bearing cells including brain, oviduct, lung, and uterus (PubMed:15827353, PubMed:32988999). Expressed in articular cartilage and bone (PubMed:26017218). Expressed from day 16 when pachytene spermatocytes are present. Note=Defects in Spag17 are the cause of primary ciliary dyskinesia only (Pcdo) phenotype. Mice are generally viable to adulthood but have a significantly shortened lifespan, with chronic morbidity. Show neonatal progressive hydrocephalus, accumulation of mucus in the respiratory passages and male infertility. Deficient mice die within 12 hours of birth with severe defects in motile cilia (PubMed:23418344). Mice also have skeletal malformations (PubMed:26017218). Male mice are infertile because of a severe defect in spermatogenesis (PubMed:29690537). Spermatids display abnormally long manchette structures and defects in the morphology of the sperm head, acrosome, and tail (PubMed:29690537). Additionally, the transport of proteins along the manchette microtubules is disrupted in the elongating spermatids (PubMed:29690537). Sequence=AAS66754.1; Type=Frameshift; Evidence=; Sequence=AAV66533.1; Type=Miscellaneous discrepancy; Note=Missing sequence in a highly repetitive region between exons 21 and 22.; Evidence=; Sequence=BAC26566.1; Type=Frameshift; Evidence=; Sequence=BAE22947.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; epithelial cilium movement protein binding extracellular region cytoplasm cytoskeleton microtubule cilium cell projection organization motile cilium cell projection axonemal central apparatus assembly axonemal central apparatus uc012cus.1 uc012cus.2 
ENSMUST00000164583.8 Scart2 ENSMUST00000164583.8 scavenger receptor family member expressed on T cells 2, transcript variant 2 (from RefSeq NM_001128146.1) 5830411N06Rik B3F5L4 B3F5L4_MOUSE ENSMUST00000164583.1 ENSMUST00000164583.2 ENSMUST00000164583.3 ENSMUST00000164583.4 ENSMUST00000164583.5 ENSMUST00000164583.6 ENSMUST00000164583.7 NM_001128146 Scart2 uc012fwi.1 uc012fwi.2 uc012fwi.3 Lacks conserved residue(s) required for the propagation of feature annotation. gamma-delta T cell lineage commitment molecular_function scavenger receptor activity endocytosis external side of plasma membrane membrane integral component of membrane interleukin-17 production uc012fwi.1 uc012fwi.2 uc012fwi.3 
ENSMUST00000164585.8 Gm3424 ENSMUST00000164585.8 Gm3424 (from geneSymbol) ENSMUST00000164585.1 ENSMUST00000164585.2 ENSMUST00000164585.3 ENSMUST00000164585.4 ENSMUST00000164585.5 ENSMUST00000164585.6 ENSMUST00000164585.7 Gm3424 L7N298 L7N298_MOUSE uc288qna.1 uc288qna.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qna.1 uc288qna.2 
ENSMUST00000164589.9 Fam98c ENSMUST00000164589.9 family with sequence similarity 98, member C (from RefSeq NM_001146023.1) E9PYD1 E9PYD1_MOUSE ENSMUST00000164589.1 ENSMUST00000164589.2 ENSMUST00000164589.3 ENSMUST00000164589.4 ENSMUST00000164589.5 ENSMUST00000164589.6 ENSMUST00000164589.7 ENSMUST00000164589.8 Fam98c NM_001146023 uc012fhc.1 uc012fhc.2 uc012fhc.3 Belongs to the FAM98 family. biological_process tRNA-splicing ligase complex uc012fhc.1 uc012fhc.2 uc012fhc.3 
ENSMUST00000164598.8 Acox2 ENSMUST00000164598.8 acyl-Coenzyme A oxidase 2, branched chain, transcript variant 1 (from RefSeq NM_053115.2) ACOX2_MOUSE Acox2 ENSMUST00000164598.1 ENSMUST00000164598.2 ENSMUST00000164598.3 ENSMUST00000164598.4 ENSMUST00000164598.5 ENSMUST00000164598.6 ENSMUST00000164598.7 NM_053115 Q8VCB0 Q9QXD1 uc007sez.1 uc007sez.2 uc007sez.3 uc007sez.4 Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (By similarity). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). Reaction=(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl- CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy- 5beta-cholestan-26-oyl-CoA + AH2; Xref=Rhea:RHEA:15733, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:58677, ChEBI:CHEBI:59807; EC=1.17.99.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15734; Evidence=; Reaction=(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl- CoA + O2 = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24- en-26-oyl-CoA + H2O2; Xref=Rhea:RHEA:46728, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:59879, ChEBI:CHEBI:77251; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46729; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Homodimer. Peroxisome Acetylation of Lys-667 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the acyl-CoA oxidase family. acyl-CoA oxidase activity fatty acid binding peroxisome cytosol lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation positive regulation of cell death oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors fatty acid beta-oxidation using acyl-CoA oxidase 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity protein homodimerization activity intracellular membrane-bounded organelle flavin adenine dinucleotide binding lipid homeostasis oxidation-reduction process FAD binding positive regulation of response to oxidative stress uc007sez.1 uc007sez.2 uc007sez.3 uc007sez.4 
ENSMUST00000164613.8 Gm5798 ENSMUST00000164613.8 predicted gene 5798 (from RefSeq NM_001374762.1) ENSMUST00000164613.1 ENSMUST00000164613.2 ENSMUST00000164613.3 ENSMUST00000164613.4 ENSMUST00000164613.5 ENSMUST00000164613.6 ENSMUST00000164613.7 F7BTS7 F7BTS7_MOUSE Gm5798 Gm8011 NM_001374762 uc288snn.1 uc288snn.2 uc288snn.1 uc288snn.2 
ENSMUST00000164632.2 Rnase10 ENSMUST00000164632.2 ribonuclease, RNase A family, 10 (non-active), transcript variant 2 (from RefSeq NM_001162863.1) ENSMUST00000164632.1 G3UWD1 G3UWD1_MOUSE NM_001162863 Rah1 Rnase10 uc011zkb.1 uc011zkb.2 Secreted Belongs to the pancreatic ribonuclease family. nucleic acid binding uc011zkb.1 uc011zkb.2 
ENSMUST00000164639.8 Htr7 ENSMUST00000164639.8 5-hydroxytryptamine (serotonin) receptor 7, transcript variant 1 (from RefSeq NM_008315.3) 5HT7R_MOUSE ENSMUST00000164639.1 ENSMUST00000164639.2 ENSMUST00000164639.3 ENSMUST00000164639.4 ENSMUST00000164639.5 ENSMUST00000164639.6 ENSMUST00000164639.7 NM_008315 P32304 Q14A50 uc008hhd.1 uc008hhd.2 uc008hhd.3 uc008hhd.4 This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity G-protein coupled serotonin receptor activity rough endoplasmic reticulum plasma membrane integral component of plasma membrane smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating serotonin receptor signaling pathway serotonin receptor signaling pathway chemical synaptic transmission memory circadian rhythm synaptic vesicle positive regulation of neuron projection development negative regulation of serotonin secretion urinary bladder smooth muscle contraction membrane integral component of membrane dendrite neurotransmitter receptor activity vasoconstriction negative regulation of circadian sleep/wake cycle, REM sleep neuronal cell body axon terminus behavioral response to pain detection of mechanical stimulus involved in sensory perception of pain response to corticosterone micturition long-term synaptic potentiation dopaminergic neuron differentiation integral component of postsynaptic membrane integral component of presynaptic membrane regulation of synaptic vesicle exocytosis uc008hhd.1 uc008hhd.2 uc008hhd.3 uc008hhd.4 
ENSMUST00000164651.9 Speer1j ENSMUST00000164651.9 Speer1j (from geneSymbol) AY151400 ENSMUST00000164651.1 ENSMUST00000164651.2 ENSMUST00000164651.3 ENSMUST00000164651.4 ENSMUST00000164651.5 ENSMUST00000164651.6 ENSMUST00000164651.7 ENSMUST00000164651.8 Gm8906 L7N2A2 L7N2A2_MOUSE uc290tds.1 uc290tds.2 uc290tds.3 uc290tds.1 uc290tds.2 uc290tds.3 
ENSMUST00000164661.4 Trim43a ENSMUST00000164661.4 tripartite motif-containing 43A, transcript variant 1 (from RefSeq NM_001357687.1) B9EIY7 ENSMUST00000164661.1 ENSMUST00000164661.2 ENSMUST00000164661.3 NM_001357687 Q3TL54 TR43A_MOUSE Trim43a uc009qyv.1 uc009qyv.2 uc009qyv.3 Expression is restricted to preimplantation embryos and peaks at the 8-cell to morula stage. Belongs to the TRIM/RBCC family. cellular_component biological_process zinc ion binding metal ion binding uc009qyv.1 uc009qyv.2 uc009qyv.3 
ENSMUST00000164663.9 Gm8220 ENSMUST00000164663.9 predicted gene 8220 (from RefSeq NM_001378717.1) A0AA74KT89 ENSMUST00000164663.1 ENSMUST00000164663.2 ENSMUST00000164663.3 ENSMUST00000164663.4 ENSMUST00000164663.5 ENSMUST00000164663.6 ENSMUST00000164663.7 ENSMUST00000164663.8 NM_001378717 uc288sut.1 uc288sut.2 uc288sut.3 uc288sut.1 uc288sut.2 uc288sut.3 
ENSMUST00000164683.2 Vmn1r119 ENSMUST00000164683.2 vomeronasal 1 receptor 119 (from RefSeq NM_001166708.1) E9Q4H3 E9Q4H3_MOUSE ENSMUST00000164683.1 NM_001166708 Vmn1r119 uc012fct.1 uc012fct.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fct.1 uc012fct.2 
ENSMUST00000164716.2 Gm17114 ENSMUST00000164716.2 Gm17114 (from geneSymbol) ENSMUST00000164716.1 uc290peq.1 uc290peq.2 uc290peq.1 uc290peq.2 
ENSMUST00000164727.8 F13a1 ENSMUST00000164727.8 coagulation factor XIII, A1 subunit, transcript variant 2 (from RefSeq NM_001166391.1) ENSMUST00000164727.1 ENSMUST00000164727.2 ENSMUST00000164727.3 ENSMUST00000164727.4 ENSMUST00000164727.5 ENSMUST00000164727.6 ENSMUST00000164727.7 F13A_MOUSE F13a NM_001166391 Q3TNF9 Q8BH61 Q8BIP2 uc007qco.1 uc007qco.2 uc007qco.3 This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit B to form a heterotetrameric proenzyme that undergoes thrombin-mediated proteolysis to generate active factor XIIIa. The transglutaminase activity of factor XIIIa is required for the calcium-dependent crosslinking of fibrin, leading to the formation of a clot. Mice lacking the encoded protein display impaired reproduction and reduced survival due to bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage. Additionally, mice lacking the encoded protein exhibit impaired wound healing and inadequate healing of myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Reaction=L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L- lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:54816, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:14005, ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:30011, ChEBI:CHEBI:138370; EC=2.3.2.13; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Tetramer of two A chains (F13A1) and two B (F13B) chains. Cytoplasm Secreted Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma. The activation peptide is released by thrombin. Belongs to the transglutaminase superfamily. Transglutaminase family. protein-glutamine gamma-glutamyltransferase activity extracellular region cytoplasm blood coagulation hemostasis transferase activity transferase activity, transferring acyl groups peptide cross-linking metal ion binding blood coagulation, fibrin clot formation uc007qco.1 uc007qco.2 uc007qco.3 
ENSMUST00000164729.3 H2al1i ENSMUST00000164729.3 H2A histone family member L1I (from RefSeq NM_001242954.1) ENSMUST00000164729.1 ENSMUST00000164729.2 H2AL1_MOUSE H2al1a H2al1c H2al1d H2al1f H2al1g H2al1h H2al1i NM_001242954 Q5M8Q2 uc029xii.1 uc029xii.2 Atypical histone H2A which can replace conventional H2A in some nucleosomes and may play a role during spermatogenesis. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes, replacing one or more H2A molecules. Interacts with H2BC1/TH2B; preferentially dimerizes with H2BC1/TH2B to form nucleosomes (PubMed:17261847). Nucleus Chromosome Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847). Testis-specific. Strongly enriched in step 12-16 spermatids and accumulate during late spermiogenesis, in condensing spermatids (PubMed:17261847). Remains present in mature spermatozoa isolated from epididymis (PubMed:17261847). Rapidly disappears from the paternal pericentric heterochromatin regions after sperm-egg fusion (PubMed:18703863). In contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding protein binding nucleus chromosome pericentric heterochromatin DNA packaging chromatin organization spermatogenesis cell differentiation DNA packaging complex protein heterodimerization activity uc029xii.1 uc029xii.2 
ENSMUST00000164734.2 Gm17120 ENSMUST00000164734.2 Gm17120 (from geneSymbol) ENSMUST00000164734.1 uc292mqq.1 uc292mqq.2 uc292mqq.1 uc292mqq.2 
ENSMUST00000164750.8 Etv4 ENSMUST00000164750.8 ets variant 4, transcript variant 2 (from RefSeq NM_008815.3) ENSMUST00000164750.1 ENSMUST00000164750.2 ENSMUST00000164750.3 ENSMUST00000164750.4 ENSMUST00000164750.5 ENSMUST00000164750.6 ENSMUST00000164750.7 ETV4_MOUSE NM_008815 P28322 Pea-3 Pea3 Q3UMZ6 uc007lpt.1 uc007lpt.2 uc007lpt.3 uc007lpt.4 Transcriptional activator (PubMed:1547944). May play a role in keratinocyte differentiation (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P28322-1; Sequence=Displayed; Name=2; IsoId=P28322-2; Sequence=VSP_047943, VSP_047944, VSP_047945; Epididymis and brain. Sumoylated; enhanced upon ERK/MAP kinase pathway activation it positively regulates the transcriptional activator capacity. Sumoylation at Lys-95 probably requires phosphorylation at Ser-100. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal- mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2. Belongs to the ETS family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleolus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter motor neuron axon guidance positive regulation of gene expression cell differentiation negative regulation of mammary gland epithelial cell proliferation sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter stem cell differentiation branching involved in mammary gland duct morphogenesis uc007lpt.1 uc007lpt.2 uc007lpt.3 uc007lpt.4 
ENSMUST00000164756.4 Eid1 ENSMUST00000164756.4 EP300 interacting inhibitor of differentiation 1 (from RefSeq NM_025613.3) Cri1 EID1_MOUSE ENSMUST00000164756.1 ENSMUST00000164756.2 ENSMUST00000164756.3 Eid1 NM_025613 Q3T9D1 Q8BP25 Q9CQ17 Q9CYM0 Q9DCR4 uc008mcx.1 uc008mcx.2 uc008mcx.3 uc008mcx.4 Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms. Interacts via its LXCXE motif with the entire pocket region of RB1. Interacts with EP300, NR0B2 and TRIM27. Nucleus Cytoplasm Note=May shuttle between nucleus and cytoplasm. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q9DCR4-1; Sequence=Displayed; Name=2 ; IsoId=Q9DCR4-2; Sequence=VSP_052455; Expressed in all adult tissues examined and during embryogenesis. Inhibition of MYOD1 may be partly due to the ability of EID1 to bind and inhibit EP300 histone acetyltransferase activity. negative regulation of transcription from RNA polymerase II promoter transcription corepressor activity protein binding nucleus nucleoplasm cytoplasm cell cycle cell differentiation histone acetyltransferase regulator activity histone acetyltransferase binding regulation of histone acetylation cytoplasmic ribonucleoprotein granule regulation of cell differentiation negative regulation of transcription, DNA-templated uc008mcx.1 uc008mcx.2 uc008mcx.3 uc008mcx.4 
ENSMUST00000164759.8 Sbf2 ENSMUST00000164759.8 SET binding factor 2, transcript variant 2 (from RefSeq NM_001404387.1) E9PXF8 E9Q305 ENSMUST00000164759.1 ENSMUST00000164759.2 ENSMUST00000164759.3 ENSMUST00000164759.4 ENSMUST00000164759.5 ENSMUST00000164759.6 ENSMUST00000164759.7 MTMRD_MOUSE NM_001404387 Q8BJ67 Q8BJD2 Q8BJP4 Q91VH0 Sbf2 uc012fsf.1 uc012fsf.2 uc012fsf.3 Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (By similarity). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Acts as an adapter for the phosphatase MTMR2 (PubMed:16399794). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (PubMed:16399794). Homodimer (PubMed:16399794). Heterotetramer consisting of one MTMR2 dimer and one SBF2/MTMR13 dimer (PubMed:16399794). Interacts with class II PI3-kinase PIK3C2A (PubMed:22648168). Interacts (via DENN domain) with RAB21 (in GDP-bound form) in response to starvation; the interaction activates RAB21 (By similarity). Interacts with VAMP8 in response to starvation (By similarity). Cytoplasm toplasm, perinuclear region Membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Cell projection, axon Note=Associated with membranes (By similarity). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). Membrane localization is likely to be mediated via its interaction with MTMR2 (PubMed:23297362). Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=E9PXF8-1; Sequence=Displayed; Name=2 ; IsoId=E9PXF8-2; Sequence=VSP_060070; Expressed in sciatic nerve and in Schwann cells (at protein level) (PubMed:16750429, PubMed:16399794, PubMed:17855448, PubMed:18349142, PubMed:23297362). Expressed in brain (at protein level) (PubMed:18349142, PubMed:22648168). Highly expressed in brain, heart, kidney and testis, and to a lesser extent in lung, stomach, small intestine, skeletal muscle, liver and placenta (PubMed:16750429). Expressed in spinal cord and eye (PubMed:16750429). Not expressed in thymus and spleen (PubMed:16750429). In 9 dpc embryos, strongly expressed in the craniofacial region, the branchial arches and in limb buds. Also expressed in brain and along the neural tube. At 9 dpc and 10 dpc, no expression is detected in the heart but at later stages expressed weakly in the ventricle. At 11 dpc and 12 dpc, highly expressed in the neural tube, limb bud, dorsal trunk and tail mesenchyme. In the brain of 13 dpc embryos, highly expressed in the cortex and the dorsal spinal cord and weakly in midbrain. The C-terminal domain mediates homodimerization (PubMed:16399794). By mediating SBF2/MTMR13 homodimerization, indirectly involved in SBF2/MTMR13 and MTMR2 homotetramerization (PubMed:16399794). The GRAM domain mediates binding to phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5- biphosphate and phosphatidylinositol 3,4,5-trisphosphate. The PH domain binds preferentially phosphatidylinositol 3,4,5- trisphosphate (PubMed:16399794). Appears to be dispensable for localization to membranes (PubMed:23297362). Mice are born at the expected Mendelian rate (PubMed:18349142). Display demyelinating peripheral neuropathy characterized by slowed nerve conduction velocity, axon degeneration, and myelin outfolding and infolding in motor and sensory peripheral nerves (PubMed:17855448, PubMed:18349142, PubMed:23297362). Defects in myelination start to appear at postnatal day 3 (P3) (PubMed:23297362). The neuropathy severity increases with age (PubMed:17855448, PubMed:23297362). Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 1433 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity. MTMR2 protein levels are decreased in sciatic nerves but not in the brain (PubMed:18349142, PubMed:23297362). However, MTMR2 protein levels have also been shown not to be affected in sciatic nerves (PubMed:17855448). guanyl-nucleotide exchange factor activity protein binding cytoplasm endosome vacuolar membrane autophagy endosome membrane membrane Rab guanyl-nucleotide exchange factor activity phosphatase regulator activity phosphatase binding axon phosphatidylinositol binding cell projection regulation of GTPase activity perinuclear region of cytoplasm uc012fsf.1 uc012fsf.2 uc012fsf.3 
ENSMUST00000164766.8 Rem2 ENSMUST00000164766.8 rad and gem related GTP binding protein 2, transcript variant 1 (from RefSeq NM_080726.4) E9Q4D5 E9Q4D5_MOUSE ENSMUST00000164766.1 ENSMUST00000164766.2 ENSMUST00000164766.3 ENSMUST00000164766.4 ENSMUST00000164766.5 ENSMUST00000164766.6 ENSMUST00000164766.7 NM_080726 Rem2 uc007twe.1 uc007twe.2 uc007twe.3 Belongs to the small GTPase superfamily. RGK family. nucleotide binding GTPase activity GTP binding signal transduction membrane negative regulation of high voltage-gated calcium channel activity uc007twe.1 uc007twe.2 uc007twe.3 
ENSMUST00000164773.2 Phlda1 ENSMUST00000164773.2 pleckstrin homology like domain, family A, member 1 (from RefSeq NM_009344.3) ENSMUST00000164773.1 NM_009344 PHLA1_MOUSE Q3TY48 Q3UG87 Q62392 Tdag51 uc007haf.1 uc007haf.2 uc007haf.3 uc007haf.4 Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. Required for TCR-induced apoptosis and expression of TNFRSF6/FAS in a T-cell hybridoma cell line. May be involved in translational regulation. Interacts with RPL14, EIF3S7 and PABPC4. Q62392; P25685: DNAJB1; Xeno; NbExp=2; IntAct=EBI-309727, EBI-357034; Q62392; P08107: HSPA1B; Xeno; NbExp=2; IntAct=EBI-309727, EBI-629985; Q62392; Q92598: HSPH1; Xeno; NbExp=2; IntAct=EBI-309727, EBI-356829; Cytoplasm Cytoplasmic vesicle Nucleus, nucleolus Note=Colocalizes with intracellular vesicles. Widely expressed with very high levels in adult liver and high levels in adult lung. According to PubMed:10428057 expressed at low levels in liver. Expressed at increased levels in atherosclerotic lesions observed in hyperhomocysteinema. Induced by IGF-I. Sequence=AAC52674.1; Type=Erroneous initiation; Evidence=; Sequence=AAH10295.1; Type=Erroneous initiation; Evidence=; Sequence=BAE34715.1; Type=Frameshift; Evidence=; protein binding nucleus nucleolus cytoplasm apoptotic process cytoplasmic vesicle positive regulation of apoptotic process FasL biosynthetic process uc007haf.1 uc007haf.2 uc007haf.3 uc007haf.4 
ENSMUST00000164782.10 Coch ENSMUST00000164782.10 cochlin, transcript variant 1 (from RefSeq NM_007728.6) COCH_MOUSE ENSMUST00000164782.1 ENSMUST00000164782.2 ENSMUST00000164782.3 ENSMUST00000164782.4 ENSMUST00000164782.5 ENSMUST00000164782.6 ENSMUST00000164782.7 ENSMUST00000164782.8 ENSMUST00000164782.9 NM_007728 Q3TAF5 Q62507 Q9QWK6 uc007nms.1 uc007nms.2 uc007nms.3 uc007nms.4 Plays a role in the control of cell shape and motility in the trabecular meshwork. Monomer. May form homodimer. Interacts with type II collagen. Interacts with SLC44A2. Interacts with ANXA2. Secreted, extracellular space Expressed in inner ear structures. N-glycosylated. Name=Protein Spotlight; Note=The Japanese Horseshoe Crab and Deafness - Issue 4 of November 2000; URL="https://web.expasy.org/spotlight/back_issues/004"; growth plate cartilage chondrocyte morphogenesis protein binding collagen binding extracellular region extracellular space sensory perception of sound regulation of cell shape extracellular matrix defense response to bacterium positive regulation of innate immune response uc007nms.1 uc007nms.2 uc007nms.3 uc007nms.4 
ENSMUST00000164787.8 Cdh18 ENSMUST00000164787.8 cadherin 18 (from RefSeq NM_001081299.1) Cdh18 E9Q9Q6 E9Q9Q6_MOUSE ENSMUST00000164787.1 ENSMUST00000164787.2 ENSMUST00000164787.3 ENSMUST00000164787.4 ENSMUST00000164787.5 ENSMUST00000164787.6 ENSMUST00000164787.7 NM_001081299 uc007vis.1 uc007vis.2 Cadherins are calcium-dependent cell adhesion proteins. Cell membrane ingle-pass type I membrane protein Membrane ; Single-pass type I membrane protein cell morphogenesis calcium ion binding plasma membrane cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cytoskeletal protein binding cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex adherens junction organization protein homodimerization activity cell-cell adhesion mediated by cadherin cadherin binding cell-cell adhesion uc007vis.1 uc007vis.2 
ENSMUST00000164792.8 Ms4a2 ENSMUST00000164792.8 membrane-spanning 4-domains, subfamily A, member 2, transcript variant 1 (from RefSeq NM_013516.2) ENSMUST00000164792.1 ENSMUST00000164792.2 ENSMUST00000164792.3 ENSMUST00000164792.4 ENSMUST00000164792.5 ENSMUST00000164792.6 ENSMUST00000164792.7 FCERB_MOUSE Fce1b Fcer1b Ms4a1 NM_013516 P20490 uc008gsn.1 uc008gsn.2 uc008gsn.3 uc008gsn.4 uc008gsn.5 This gene encodes a member of the membrane-spanning 4A family. The encoded protein is the beta subunit of the high affinity IgE receptor and is localized to the membrane. The encoded protein is required for full activation of mast cells, including the release of histamine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor- bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR (By similarity). Interacts with FGR and FES/FPS. Interacts with LYN. Membrane; Multi-pass membrane protein. Phosphorylated on tyrosine residues by LYN. Belongs to the MS4A family. endosome integral component of plasma membrane inflammatory response immune response signal transduction cell surface receptor signaling pathway activation of phospholipase C activity protein kinase C-activating G-protein coupled receptor signaling pathway external side of plasma membrane membrane integral component of membrane IgE binding protein kinase binding Fc-epsilon receptor I complex Fc-epsilon receptor signaling pathway SH2 domain binding positive regulation of mast cell degranulation membrane raft cytokine secretion phosphoprotein binding regulation of release of sequestered calcium ion into cytosol IgE receptor activity uc008gsn.1 uc008gsn.2 uc008gsn.3 uc008gsn.4 uc008gsn.5 
ENSMUST00000164800.8 Zfp185 ENSMUST00000164800.8 zinc finger protein 185, transcript variant 1 (from RefSeq NM_009549.3) ENSMUST00000164800.1 ENSMUST00000164800.2 ENSMUST00000164800.3 ENSMUST00000164800.4 ENSMUST00000164800.5 ENSMUST00000164800.6 ENSMUST00000164800.7 G5E8W8 G5E8W8_MOUSE NM_009549 Zfp185 uc009tkw.1 uc009tkw.2 uc009tkw.3 actin cytoskeleton metal ion binding actin filament binding uc009tkw.1 uc009tkw.2 uc009tkw.3 
ENSMUST00000164804.2 Gm17056 ENSMUST00000164804.2 Gm17056 (from geneSymbol) AK040229 ENSMUST00000164804.1 uc288gbh.1 uc288gbh.2 uc288gbh.1 uc288gbh.2 
ENSMUST00000164822.8 Rcbtb2 ENSMUST00000164822.8 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2, transcript variant 2 (from RefSeq NM_134083.4) Chc1l ENSMUST00000164822.1 ENSMUST00000164822.2 ENSMUST00000164822.3 ENSMUST00000164822.4 ENSMUST00000164822.5 ENSMUST00000164822.6 ENSMUST00000164822.7 G1EE51 NM_134083 Q3TUA3 Q8BMG2 Q99LJ7 RCBT2_MOUSE uc007upk.1 uc007upk.2 uc007upk.3 uc007upk.4 uc007upk.5 Cytoplasmic vesicle, secretory vesicle, acrosome Note=Mainly found in the acrosomal cap region. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99LJ7-1; Sequence=Displayed; Name=2; IsoId=Q99LJ7-2; Sequence=VSP_016724; Expressed in testis and heart (at protein level). Expressed in testis from postnatal day 12 onwards, reaching maximal levels at postnatal day 30 (at protein level). The BTB domain might play a role in targeting to acrosomal vesicles. acrosomal vesicle molecular_function biological_process cytoplasmic vesicle uc007upk.1 uc007upk.2 uc007upk.3 uc007upk.4 uc007upk.5 
ENSMUST00000164826.8 Card10 ENSMUST00000164826.8 Card10 (from geneSymbol) BC060203 Card10 E9PUV9 E9PUV9_MOUSE ENSMUST00000164826.1 ENSMUST00000164826.2 ENSMUST00000164826.3 ENSMUST00000164826.4 ENSMUST00000164826.5 ENSMUST00000164826.6 ENSMUST00000164826.7 uc007wrk.1 uc007wrk.2 uc007wrk.3 activation of NF-kappaB-inducing kinase activity regulation of apoptotic process negative regulation of cell migration involved in sprouting angiogenesis positive regulation of protein localization to nucleus uc007wrk.1 uc007wrk.2 uc007wrk.3 
ENSMUST00000164832.9 Dpy30 ENSMUST00000164832.9 dpy-30, histone methyltransferase complex regulatory subunit, transcript variant 1 (from RefSeq NM_024428.4) DPY30_MOUSE ENSMUST00000164832.1 ENSMUST00000164832.2 ENSMUST00000164832.3 ENSMUST00000164832.4 ENSMUST00000164832.5 ENSMUST00000164832.6 ENSMUST00000164832.7 ENSMUST00000164832.8 NM_024428 Q99LT0 uc008dny.1 uc008dny.2 uc008dny.3 uc008dny.4 As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play an indirect or direct role in endosomal transport. Homodimer. Core component of several methyltransferase- containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts with ASH2L. The interaction with ASH2L is direct (By similarity). Interacts with ARFGEF1 (By similarity). Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (By similarity). Nucleus Golgi apparatus, trans-Golgi network Note=Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys-4'. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs. Belongs to the dpy-30 family. nucleus nucleoplasm Golgi apparatus trans-Golgi network chromatin organization endosomal transport histone methyltransferase complex identical protein binding protein homodimerization activity MLL3/4 complex Set1C/COMPASS complex histone H3-K4 methylation uc008dny.1 uc008dny.2 uc008dny.3 uc008dny.4 
ENSMUST00000164834.3 Gpr62 ENSMUST00000164834.3 G protein-coupled receptor 62 (from RefSeq NM_001159652.2) ENSMUST00000164834.1 ENSMUST00000164834.2 GPR62_MOUSE NM_001159652 Q80UC6 Q8CEQ6 uc012gzw.1 uc012gzw.2 uc012gzw.3 Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28912303). Has spontaneous activity for beta-arrestin recruitment (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). Homodimer (PubMed:28912303). Forms heterodimer with MTNR1B (By similarity). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR62 in the endosomal compartment (By similarity). Cell membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein Note=Colocalizes with ARRB2 in the endosome. Expressed in the brain and testes. Expressed widely, in the brain, including the cerebral cortex, cerebellum, hippocampus,thalamus and pituitary gland. In the testes, expressed specifically in the germ cells. Expression in the testes starts 25 days after birth and continues thereafter. Lacks the conserved DRY and BBXXB motifs. The restoration of these motifs affects its constitutive activity. Deficient mice show any abnormality in growth and behavior. Both male and female are fertile. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity endosome plasma membrane signal transduction G-protein coupled receptor signaling pathway endosome membrane membrane integral component of membrane identical protein binding receptor complex positive regulation of cAMP-mediated signaling inositol phosphate-mediated signaling arrestin family protein binding uc012gzw.1 uc012gzw.2 uc012gzw.3 
ENSMUST00000164838.3 Eif1ad6 ENSMUST00000164838.3 eukaryotic translation initiation factor 1A domain containing 6 (from RefSeq NM_001177564.1) BB287469 ENSMUST00000164838.1 ENSMUST00000164838.2 Eif1ad2 Eif1ad6 Gm4027 NM_001177564 Q3UT53 Q3UT53_MOUSE uc007ojk.1 uc007ojk.2 uc007ojk.3 uc007ojk.4 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. molecular_function RNA binding translation initiation factor activity cellular_component translation translational initiation biological_process uc007ojk.1 uc007ojk.2 uc007ojk.3 uc007ojk.4 
ENSMUST00000164843.10 Capn1 ENSMUST00000164843.10 calpain 1, transcript variant 2 (from RefSeq NM_001110504.1) Capn1 ENSMUST00000164843.1 ENSMUST00000164843.2 ENSMUST00000164843.3 ENSMUST00000164843.4 ENSMUST00000164843.5 ENSMUST00000164843.6 ENSMUST00000164843.7 ENSMUST00000164843.8 ENSMUST00000164843.9 NM_001110504 Q3TI07 Q3TI07_MOUSE uc008ggk.1 uc008ggk.2 uc008ggk.3 uc008ggk.4 Reaction=Broad endopeptidase specificity.; EC=3.4.22.52; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Cell membrane Cytoplasm Membrane Belongs to the peptidase C2 family. calcium-dependent cysteine-type endopeptidase activity calcium ion binding cytosol plasma membrane proteolysis peptidase activity cysteine-type peptidase activity membrane hydrolase activity regulation of catalytic activity self proteolysis uc008ggk.1 uc008ggk.2 uc008ggk.3 uc008ggk.4 
ENSMUST00000164845.4 Vmn2r45 ENSMUST00000164845.4 vomeronasal 2, receptor 45 (from RefSeq NM_001105075.1) ENSMUST00000164845.1 ENSMUST00000164845.2 ENSMUST00000164845.3 L7N2B5 L7N2B5_MOUSE NM_001105075 Vmn2r45 uc012eyg.1 uc012eyg.2 uc012eyg.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012eyg.1 uc012eyg.2 uc012eyg.3 
ENSMUST00000164848.3 Siah3 ENSMUST00000164848.3 siah E3 ubiquitin protein ligase family member 3 (from RefSeq NM_001128093.2) B2RWG3 B2RWG3_MOUSE ENSMUST00000164848.1 ENSMUST00000164848.2 Gm912 NM_001128093 Siah3 uc011zom.1 uc011zom.2 uc011zom.3 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. The RING-type zinc finger domain is essential for ubiquitin ligase activity. The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. Belongs to the SINA (Seven in absentia) family. nucleus mitochondrion ubiquitin-dependent protein catabolic process multicellular organism development protein ubiquitination ubiquitin conjugating enzyme binding regulation of protein stability proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity negative regulation of protein targeting to mitochondrion uc011zom.1 uc011zom.2 uc011zom.3 
ENSMUST00000164856.3 Vmn2r116 ENSMUST00000164856.3 vomeronasal 2, receptor 116 (from RefSeq NM_001104580.1) D7URW5 E9Q6I0 ENSMUST00000164856.1 ENSMUST00000164856.2 NM_001104580 V2116_MOUSE V2rp5 Vmn2r116 uc009vbt.1 uc009vbt.2 uc009vbt.3 Receptor for the Esp1 pheromone. Mediates the response to Esp1 which enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation. Cell membrane ; Multi-pass membrane protein Expressed in the vomeronasal organ. No response of neurons in the vomeronasal organ or accessory olfactory bulb to Esp1 and no enhancement of lordosis following exposure to Esp1. Belongs to the G-protein coupled receptor 3 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone signaling receptor activity positive regulation of female receptivity uc009vbt.1 uc009vbt.2 uc009vbt.3 
ENSMUST00000164863.2 Gm20458 ENSMUST00000164863.2 Golgi apparatus membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PXJ7) AK003735 E9PXJ7 E9PXJ7_MOUSE ENSMUST00000164863.1 Gm20458 uc290cke.1 uc290cke.2 Golgi apparatus membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the SYS1 family. trans-Golgi network cytosol Golgi to endosome transport membrane integral component of membrane integral component of Golgi membrane protein localization to Golgi apparatus Golgi to plasma membrane protein transport uc290cke.1 uc290cke.2 
ENSMUST00000164875.3 Vmn2r11 ENSMUST00000164875.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q4X4) E9Q4X4 E9Q4X4_MOUSE ENSMUST00000164875.1 ENSMUST00000164875.2 Vmn2r11 uc009vdi.1 uc009vdi.2 uc009vdi.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vdi.1 uc009vdi.2 uc009vdi.3 
ENSMUST00000164880.4 Vmn1r61 ENSMUST00000164880.4 vomeronasal 1 receptor 61 (from RefSeq NM_001166733.1) ENSMUST00000164880.1 ENSMUST00000164880.2 ENSMUST00000164880.3 NM_001166733 Vmn1r61 W4VSP5 W4VSP5_MOUSE uc012exg.1 uc012exg.2 uc012exg.3 uc012exg.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012exg.1 uc012exg.2 uc012exg.3 uc012exg.4 
ENSMUST00000164884.9 Ciao2b ENSMUST00000164884.9 cytosolic iron-sulfur assembly component 2B (from RefSeq NM_026753.2) CIA2B_MOUSE Ciao2b ENSMUST00000164884.1 ENSMUST00000164884.2 ENSMUST00000164884.3 ENSMUST00000164884.4 ENSMUST00000164884.5 ENSMUST00000164884.6 ENSMUST00000164884.7 ENSMUST00000164884.8 Fam96b Mip18 NM_026753 Q9D187 uc033jhf.1 uc033jhf.2 uc033jhf.3 Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5. Interacts with CIAO1, ERCC2 and MMS19; the interactions are direct. Interacts with KIF4A; the interaction facilitates the transfer of Fe-S clusters to KIF4A to ensure proper localization of KIF4A to the mitotic machinery. Interacts with CCDC117; the interaction is direct (By similarity). Nucleus Cytoplasm, cytoskeleton, spindle Belongs to the MIP18 family. molecular_function nucleus nucleoplasm cytoplasm spindle cytosol cytoskeleton chromosome segregation iron-sulfur cluster assembly MMXD complex CIA complex protein maturation by iron-sulfur cluster transfer uc033jhf.1 uc033jhf.2 uc033jhf.3 
ENSMUST00000164886.2 Pilrb2 ENSMUST00000164886.2 paired immunoglobin-like type 2 receptor beta 2, transcript variant 3 (from RefSeq NR_169051.1) ENSMUST00000164886.1 NR_169051 PILB2_MOUSE Q2YFS1 uc009aee.1 uc009aee.2 Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB2 is probably a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. Membrane ; Single-pass type I membrane protein membrane integral component of membrane MHC class I protein binding uc009aee.1 uc009aee.2 
ENSMUST00000164916.9 Mix23 ENSMUST00000164916.9 mitochondrial matrix import factor 23, transcript variant 1 (from RefSeq NM_198645.2) Ccdc58 ENSMUST00000164916.1 ENSMUST00000164916.2 ENSMUST00000164916.3 ENSMUST00000164916.4 ENSMUST00000164916.5 ENSMUST00000164916.6 ENSMUST00000164916.7 ENSMUST00000164916.8 MIX23_MOUSE Mix23 NM_198645 Q3UXM5 Q8R3Q6 uc007zce.1 uc007zce.2 uc007zce.3 uc007zce.4 Belongs to the MIX23 family. molecular_function mitochondrion biological_process uc007zce.1 uc007zce.2 uc007zce.3 uc007zce.4 
ENSMUST00000164918.3 Vmn2r52 ENSMUST00000164918.3 vomeronasal 2, receptor 52 (from RefSeq NM_001105191.1) ENSMUST00000164918.1 ENSMUST00000164918.2 L7N2B2 L7N2B2_MOUSE NM_001105191 Vmn2r52 uc012eyq.1 uc012eyq.2 uc012eyq.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012eyq.1 uc012eyq.2 uc012eyq.3 
ENSMUST00000164932.3 Krt78 ENSMUST00000164932.3 keratin 78 (from RefSeq NM_212487.4) E9Q0F0 E9Q0F0_MOUSE ENSMUST00000164932.1 ENSMUST00000164932.2 Krt78 NM_212487 uc007xuh.1 uc007xuh.2 uc007xuh.3 molecular_function intermediate filament biological_process keratin filament uc007xuh.1 uc007xuh.2 uc007xuh.3 
ENSMUST00000164935.3 Heatr4 ENSMUST00000164935.3 HEAT repeat containing 4 (from RefSeq NM_001376939.1) E9Q357 E9Q357_MOUSE ENSMUST00000164935.1 ENSMUST00000164935.2 Gm17673 Heatr4 NM_001376939 uc288htd.1 uc288htd.2 molecular_function cellular_component biological_process uc288htd.1 uc288htd.2 
ENSMUST00000164936.10 Zfp493 ENSMUST00000164936.10 zinc finger protein 493 (from RefSeq NM_028402.2) E9Q1L8 E9Q1L8_MOUSE ENSMUST00000164936.1 ENSMUST00000164936.2 ENSMUST00000164936.3 ENSMUST00000164936.4 ENSMUST00000164936.5 ENSMUST00000164936.6 ENSMUST00000164936.7 ENSMUST00000164936.8 ENSMUST00000164936.9 NM_028402 Zfp493 uc007rbn.1 uc007rbn.2 uc007rbn.3 uc007rbn.4 uc007rbn.5 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007rbn.1 uc007rbn.2 uc007rbn.3 uc007rbn.4 uc007rbn.5 
ENSMUST00000164944.2 Tmc3 ENSMUST00000164944.2 Membrane ulti-pass membrane protein (from UniProt E9Q6Y0) BC156723 E9Q6Y0 E9Q6Y0_MOUSE ENSMUST00000164944.1 Tmc3 uc291scx.1 uc291scx.2 Membrane ulti-pass membrane protein Belongs to the TMC family. integral component of plasma membrane membrane integral component of membrane uc291scx.1 uc291scx.2 
ENSMUST00000164950.11 Tmem191 ENSMUST00000164950.11 transmembrane protein 191 (from RefSeq NM_177473.3) E9Q1C2 ENSMUST00000164950.1 ENSMUST00000164950.10 ENSMUST00000164950.2 ENSMUST00000164950.3 ENSMUST00000164950.4 ENSMUST00000164950.5 ENSMUST00000164950.6 ENSMUST00000164950.7 ENSMUST00000164950.8 ENSMUST00000164950.9 MNCb-4137 NM_177473 Q9JJB1 T191_MOUSE Tmem191 Tmem191c uc012abr.1 uc012abr.2 uc012abr.3 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q9JJB1-1; Sequence=Displayed; Name=2 ; IsoId=Q9JJB1-2; Sequence=VSP_057637; Belongs to the TMEM191 family. molecular_function cellular_component biological_process membrane integral component of membrane uc012abr.1 uc012abr.2 uc012abr.3 
ENSMUST00000164954.3 Kcnmb3 ENSMUST00000164954.3 potassium large conductance calcium-activated channel, subfamily M, beta member 3 (from RefSeq NM_001195074.1) E9Q7U0 E9Q7U0_MOUSE ENSMUST00000164954.1 ENSMUST00000164954.2 Kcnmb3 NM_001195074 uc012col.1 uc012col.2 uc012col.3 Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer. Membrane ulti-pass membrane protein N-glycosylated. Belongs to the KCNMB (TC 8.A.14.1) family. action potential detection of calcium ion integral component of plasma membrane potassium ion transport voltage-gated potassium channel complex calcium-activated potassium channel activity potassium channel regulator activity membrane integral component of membrane neuronal action potential potassium ion transmembrane transport uc012col.1 uc012col.2 uc012col.3 
ENSMUST00000164960.4 Rasgef1a ENSMUST00000164960.4 RasGEF domain family, member 1A, transcript variant 5 (from RefSeq NM_001362105.1) A6H650 A6H650_MOUSE E9Q1N6 ENSMUST00000164960.1 ENSMUST00000164960.2 ENSMUST00000164960.3 NM_001362105 Rasgef1a uc009dlj.1 uc009dlj.2 uc009dlj.3 uc009dlj.4 guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity cellular_component small GTPase mediated signal transduction cell migration positive regulation of Ras protein signal transduction uc009dlj.1 uc009dlj.2 uc009dlj.3 uc009dlj.4 
ENSMUST00000164965.3 Iqcf1 ENSMUST00000164965.3 IQ motif containing F1, transcript variant 2 (from RefSeq NM_001146701.1) ENSMUST00000164965.1 ENSMUST00000164965.2 IQCF1_MOUSE Iqcf1 NM_001146701 Q810M2 Q9D9K8 uc009rkd.1 uc009rkd.2 uc009rkd.3 uc009rkd.4 Involved in sperm capacitation and acrosome reaction. Interacts with calmodulin. Cytoplasmic vesicle, secretory vesicle, acrosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D9K8-1; Sequence=Displayed; Name=2; IsoId=Q9D9K8-2; Sequence=VSP_024186; Specifically expressed in testes and mature spermatozoa (at protein level). Homozygote Iqcf1 mice are significantly less fertile because of reduced sperm motility and acrosome reaction. acrosomal vesicle protein binding calmodulin binding cytoplasmic vesicle positive regulation of flagellated sperm motility involved in capacitation positive regulation of acrosome reaction uc009rkd.1 uc009rkd.2 uc009rkd.3 uc009rkd.4 
ENSMUST00000164985.4 Or5m9b ENSMUST00000164985.4 olfactory receptor family 5 subfamily M member 9B (from RefSeq NM_207142.2) ENSMUST00000164985.1 ENSMUST00000164985.2 ENSMUST00000164985.3 NM_207142 Olfr1036 Or5m9b Q7TR85 Q7TR85_MOUSE uc008klm.1 uc008klm.2 uc008klm.3 uc008klm.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC145856.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008klm.1 uc008klm.2 uc008klm.3 uc008klm.4 
ENSMUST00000164996.2 Vmn2r77 ENSMUST00000164996.2 vomeronasal 2, receptor 77 (from RefSeq NM_001105188.1) ENSMUST00000164996.1 L7N2B7 L7N2B7_MOUSE NM_001105188 Vmn2r77 uc012foq.1 uc012foq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012foq.1 uc012foq.2 
ENSMUST00000165000.9 Ankrd65 ENSMUST00000165000.9 ankyrin repeat domain 65 (from RefSeq NM_001370822.1) Ankrd65 E230028L10Rik ENSMUST00000165000.1 ENSMUST00000165000.2 ENSMUST00000165000.3 ENSMUST00000165000.4 ENSMUST00000165000.5 ENSMUST00000165000.6 ENSMUST00000165000.7 ENSMUST00000165000.8 F6YK91 F6YK91_MOUSE NM_001370822 uc290snh.1 uc290snh.2 uc290snh.3 molecular_function cellular_component biological_process uc290snh.1 uc290snh.2 uc290snh.3 
ENSMUST00000165007.9 Klhdc3 ENSMUST00000165007.9 kelch domain containing 3, transcript variant 2 (from RefSeq NM_001163729.2) A0A0R4J0W0 A0A0R4J0W0_MOUSE ENSMUST00000165007.1 ENSMUST00000165007.2 ENSMUST00000165007.3 ENSMUST00000165007.4 ENSMUST00000165007.5 ENSMUST00000165007.6 ENSMUST00000165007.7 ENSMUST00000165007.8 Klhdc3 NM_001163729 uc008ctx.1 uc008ctx.2 uc008ctx.3 uc008ctx.4 uc008ctx.5 nuclear chromatin chromatin binding nucleoplasm cytoplasm uc008ctx.1 uc008ctx.2 uc008ctx.3 uc008ctx.4 uc008ctx.5 
ENSMUST00000165015.9 Trim13 ENSMUST00000165015.9 tripartite motif-containing 13, transcript variant 1 (from RefSeq NM_001164220.1) A6H6L2 ENSMUST00000165015.1 ENSMUST00000165015.2 ENSMUST00000165015.3 ENSMUST00000165015.4 ENSMUST00000165015.5 ENSMUST00000165015.6 ENSMUST00000165015.7 ENSMUST00000165015.8 NM_001164220 Q8CEV0 Q923J0 Q925P1 Q99PQ0 Q9CYB0 Rfp2 TRI13_MOUSE uc007ufy.1 uc007ufy.2 uc007ufy.3 uc007ufy.4 uc007ufy.5 Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER- associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress- induced autophagy, and may act as a tumor suppressor. Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation. Participates as well in T-cell receptor-mediated NF-kappa-B activation. In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts (via C-terminal domain) with VCP. Interacts with AKT1; the interaction ubiquitinates AKT1 and leads to its proteasomal degradation. Interacts with MDM2; the interaction ubiquitinates AKT1 and leads to its proteasomal degradation. Interacts with p62/SQSTM1. Interacts with TRAF6. Interacts with IKBKG/NEMO. Endoplasmic reticulum membrane ; Single-pass membrane protein Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum. The coiled-coil domain is required for the induction of autophagy during endoplasmic reticulum (ER) stress. The RING-type zinc finger is required for auto- polyubiquitination. The C-terminal transmembrane domain is indispensable for the localization to the ER. Auto-ubiquitinated; requires the RING-type zinc finger. Auto- polyubiquitination leads to proteasomal degradation. Belongs to the TRIM/RBCC family. immune system process ubiquitin-protein transferase activity cytoplasm endoplasmic reticulum endoplasmic reticulum membrane zinc ion binding response to gamma radiation positive regulation of cell death membrane integral component of membrane positive regulation of macroautophagy protein ubiquitination transferase activity ER-associated ubiquitin-dependent protein catabolic process negative regulation of viral transcription positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process innate immune response metal ion binding positive regulation of NF-kappaB transcription factor activity protein autoubiquitination perinuclear endoplasmic reticulum negative regulation of viral release from host cell uc007ufy.1 uc007ufy.2 uc007ufy.3 uc007ufy.4 uc007ufy.5 
ENSMUST00000165017.2 Nolc1 ENSMUST00000165017.2 nucleolar and coiled-body phosphoprotein 1, transcript variant 3 (from RefSeq NM_001039352.2) E9Q5C9 ENSMUST00000165017.1 Kiaa0035 NM_001039352 NOLC1_MOUSE Nolc1 Q3TKZ9 Q3U6W2 Q3UBB6 Q3UI16 Q6ZQK6 Q8CE21 uc008hsh.1 uc008hsh.2 uc008hsh.3 uc008hsh.4 uc008hsh.5 Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (By similarity). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (By similarity). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:11424213). It has intrinsic GTPase and ATPase activities (By similarity). Interacts with RNA polymerase I 194 kDa subunit (RPA194) and with casein kinase-II (By similarity). Interacts with DKC1/NAP57, NOP58 and fibrillarin (By similarity). Nucleus, nucleolus Cytoplasm Note=Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q5C9-1; Sequence=Displayed; Name=2; IsoId=E9Q5C9-2; Sequence=VSP_058892, VSP_058893; Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. NOLC1 is one of the mostly phosphorylated proteins in the cell. Pyrophosphorylated by 5-diphosphoinositol pentakisphosphate (5- IP7) (PubMed:15604408). Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue (PubMed:15604408, PubMed:17873058). Ubiquitinated. Monoubiquitination by the BCR(KBTBD8) complex promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Belongs to the NOLC1 family. RNA polymerase I core binding fibrillar center DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm nucleolus cytoplasm regulation of translation response to osmotic stress nucleolus organization transcription factor binding nuclear localization sequence binding positive regulation of cell proliferation neural crest formation neural crest cell development Cajal body protein domain specific binding small nuclear ribonucleoprotein complex box C/D snoRNP complex box H/ACA snoRNP complex box H/ACA snoRNA metabolic process box C/D snoRNA binding box H/ACA snoRNA binding regulation of protein import into nucleus positive regulation of transcription, DNA-templated protein heterodimerization activity uc008hsh.1 uc008hsh.2 uc008hsh.3 uc008hsh.4 uc008hsh.5 
ENSMUST00000165029.3 Vmn2r57 ENSMUST00000165029.3 vomeronasal 2, receptor 57 (from RefSeq NM_177764.4) ENSMUST00000165029.1 ENSMUST00000165029.2 L7N269 L7N269_MOUSE NM_177764 Vmn2r57 uc009vek.1 uc009vek.2 uc009vek.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vek.1 uc009vek.2 uc009vek.3 
ENSMUST00000165032.9 Snx24 ENSMUST00000165032.9 sorting nexing 24, transcript variant 1 (from RefSeq NM_029394.4) ENSMUST00000165032.1 ENSMUST00000165032.2 ENSMUST00000165032.3 ENSMUST00000165032.4 ENSMUST00000165032.5 ENSMUST00000165032.6 ENSMUST00000165032.7 ENSMUST00000165032.8 NM_029394 Q9CRB0 SNX24_MOUSE uc008ext.1 uc008ext.2 uc008ext.3 uc008ext.4 uc008ext.5 May be involved in several stages of intracellular trafficking. Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)). Belongs to the sorting nexin family. cellular_component biological_process lipid binding phosphatidylinositol-5-phosphate binding protein transport membrane cytoplasmic vesicle membrane cytoplasmic vesicle phosphatidylinositol-3-phosphate binding phosphatidylinositol binding phosphatidylinositol-4-phosphate binding uc008ext.1 uc008ext.2 uc008ext.3 uc008ext.4 uc008ext.5 
ENSMUST00000165045.9 Siglech ENSMUST00000165045.9 Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. (from UniProt B7ZMQ6) B7ZMQ6 B7ZMQ6_MOUSE BC144742 ENSMUST00000165045.1 ENSMUST00000165045.2 ENSMUST00000165045.3 ENSMUST00000165045.4 ENSMUST00000165045.5 ENSMUST00000165045.6 ENSMUST00000165045.7 ENSMUST00000165045.8 Siglech uc012flh.1 uc012flh.2 uc012flh.3 uc012flh.4 Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. receptor-mediated endocytosis cell surface membrane integral component of membrane cargo receptor activity sialic acid binding uc012flh.1 uc012flh.2 uc012flh.3 uc012flh.4 
ENSMUST00000165046.2 Skint8 ENSMUST00000165046.2 selection and upkeep of intraepithelial T cells 8 (from RefSeq NM_001100466.1) A7TZF9 A7TZG0 A7XV07 A7XV10 E9QA97 ENSMUST00000165046.1 NM_001100466 SKIT8_MOUSE uc009vcu.1 uc009vcu.2 uc009vcu.3 May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=A7XV07-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=A7XV07-2; Sequence=VSP_034894, VSP_034895; Name=3; Synonyms=C; IsoId=A7XV07-3; Sequence=VSP_034892, VSP_034893; Expressed in skin, thymus, testis and, to a lower extent, bladder, brain, heart, kidney, mammary gland, small intestine and uterus. Encoded by one of the 11 copies of Skint genes clustered in the D1 region of the chromosome 4. Belongs to the SKINT family. Sequence=ABS30725.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=ABS30726.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=ABU87905.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=ABU87906.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; receptor binding external side of plasma membrane membrane integral component of membrane regulation of immune response T cell receptor signaling pathway uc009vcu.1 uc009vcu.2 uc009vcu.3 
ENSMUST00000165067.9 Acss3 ENSMUST00000165067.9 acyl-CoA synthetase short-chain family member 3, transcript variant 1 (from RefSeq NM_001142804.2) ACSS3_MOUSE ENSMUST00000165067.1 ENSMUST00000165067.2 ENSMUST00000165067.3 ENSMUST00000165067.4 ENSMUST00000165067.5 ENSMUST00000165067.6 ENSMUST00000165067.7 ENSMUST00000165067.8 NM_001142804 Q14DH7 Q8BZX0 uc011xna.1 uc011xna.2 uc011xna.3 Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (By similarity). Propionate is the preferred substrate but can also utilize acetate and butyrate with a much lower affinity (By similarity). Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:456215; EC=6.2.1.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23177; Evidence=; Reaction=ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA; Xref=Rhea:RHEA:20373, ChEBI:CHEBI:17272, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392, ChEBI:CHEBI:456215; EC=6.2.1.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20374; Evidence=; Reaction=ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate; Xref=Rhea:RHEA:46172, ChEBI:CHEBI:17968, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46173; Evidence=; Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14DH7-1; Sequence=Displayed; Name=2; IsoId=Q14DH7-2; Sequence=VSP_031693, VSP_031694; Belongs to the ATP-dependent AMP-binding enzyme family. nucleotide binding catalytic activity acetate-CoA ligase activity ATP binding mitochondrion mitochondrial matrix biological_process ligase activity butyrate-CoA ligase activity propionate-CoA ligase activity uc011xna.1 uc011xna.2 uc011xna.3 
ENSMUST00000165087.8 Mak ENSMUST00000165087.8 male germ cell-associated kinase, transcript variant 1 (from RefSeq NM_001145803.1) E9Q4B2 E9QAU5 E9QKR3 ENSMUST00000165087.1 ENSMUST00000165087.2 ENSMUST00000165087.3 ENSMUST00000165087.4 ENSMUST00000165087.5 ENSMUST00000165087.6 ENSMUST00000165087.7 MAK_MOUSE NM_001145803 Q04859 Q8CDL5 Rck uc007qew.1 uc007qew.2 uc007qew.3 Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. Could have an important function in sensory cells and in spermatogenesis. May participate in signaling pathways used in visual and olfactory sensory transduction. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts with AR and CDK20. Found in a complex containing MAK, AR and NCOA3. Interacts with FZR1 (via WD repeats) (By similarity). Interacts with RP1. Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Midbody Cell projection, cilium, photoreceptor outer segment Photoreceptor inner segment Note=Localizes in both the connecting cilia and the outer segment axonemes. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q04859-1; Sequence=Displayed; Name=2; IsoId=Q04859-2; Sequence=VSP_042474; Name=3; IsoId=Q04859-3; Sequence=VSP_042472, VSP_042473; In pre- and postmeiotic male germ cells in testis. In photoreceptor cells of the retina and in the olfactory receptors, and in certain epithelia of the respiratory tract and choroid plexus (brain). On day 14 or 17 of embryonic development. Expression is observed in germ cells at the stages of late pachytene spermatocytes through to early round spermatids. Autophosphorylated. Phosphorylated on serine and threonine residues (By similarity). Mice are mostly fertile, develop normally, and exhibit no gross abnormalities and spermatogenesis is intact. However, both sperm motility and litter size is reduced. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding photoreceptor outer segment photoreceptor inner segment transcription coactivator activity protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm centrosome microtubule organizing center spindle cytoskeleton cilium axoneme protein phosphorylation regulation of gene expression kinase activity phosphorylation transferase activity midbody motile cilium photoreceptor connecting cilium intracellular signal transduction intraciliary transport cell projection photoreceptor cell maintenance protein autophosphorylation metal ion binding cilium assembly mitotic spindle ciliary tip negative regulation of non-motile cilium assembly positive regulation of nucleic acid-templated transcription uc007qew.1 uc007qew.2 uc007qew.3 
ENSMUST00000165088.8 Tmprss5 ENSMUST00000165088.8 transmembrane protease, serine 5 (spinesin), transcript variant 1 (from RefSeq NM_001359460.2) E9Q2A5 ENSMUST00000165088.1 ENSMUST00000165088.2 ENSMUST00000165088.3 ENSMUST00000165088.4 ENSMUST00000165088.5 ENSMUST00000165088.6 ENSMUST00000165088.7 NM_001359460 Q9ER02 Q9ER03 Q9ER04 TMPS5_MOUSE uc009piw.1 uc009piw.2 uc009piw.3 uc009piw.4 uc009piw.5 May play a role in hearing. Cell membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=4; Name=4; IsoId=Q9ER04-1; Sequence=Displayed; Name=1; IsoId=Q9ER04-2; Sequence=VSP_005397, VSP_005398; Name=2; IsoId=Q9ER04-3; Sequence=VSP_005395; Name=3; IsoId=Q9ER04-4; Sequence=VSP_005396; Belongs to the peptidase S1 family. serine-type endopeptidase activity scavenger receptor activity plasma membrane proteolysis endocytosis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity neuronal cell body uc009piw.1 uc009piw.2 uc009piw.3 uc009piw.4 uc009piw.5 
ENSMUST00000165096.10 Mvp ENSMUST00000165096.10 major vault protein (from RefSeq NM_080638.4) ENSMUST00000165096.1 ENSMUST00000165096.2 ENSMUST00000165096.3 ENSMUST00000165096.4 ENSMUST00000165096.5 ENSMUST00000165096.6 ENSMUST00000165096.7 ENSMUST00000165096.8 ENSMUST00000165096.9 MVP_MOUSE NM_080638 Q922X6 Q9EQK5 uc009jtw.1 uc009jtw.2 uc009jtw.3 uc009jtw.4 uc009jtw.5 Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity). The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1 (By similarity). May interact with ZNF540 (By similarity). Interacts with TEP1. Cytoplasm Nucleus MVP 3 mediates interaction with PTEN. MVP 4 mediates interaction with PARP4. Phosphorylated on Tyr residues after EGF stimulation. Dephosphorylated by PTPN11. nucleus cytoplasm cytosol cytoskeleton cell proliferation protein kinase binding protein phosphatase binding negative regulation of signaling negative regulation of protein autophosphorylation ERBB signaling pathway identical protein binding perinuclear region of cytoplasm negative regulation of protein tyrosine kinase activity protein activation cascade uc009jtw.1 uc009jtw.2 uc009jtw.3 uc009jtw.4 uc009jtw.5 
ENSMUST00000165117.8 Cdk6 ENSMUST00000165117.8 cyclin dependent kinase 6 (from RefSeq NM_009873.3) CDK6_MOUSE Cdkn6 Crk2 ENSMUST00000165117.1 ENSMUST00000165117.2 ENSMUST00000165117.3 ENSMUST00000165117.4 ENSMUST00000165117.5 ENSMUST00000165117.6 ENSMUST00000165117.7 NM_009873 Q64261 Q9R1D2 Q9R1D3 uc008wgu.1 uc008wgu.2 uc008wgu.3 uc008wgu.4 This gene encodes a member of the cyclin dependent kinase family of proteins that play important roles in the progression and regulation of the cell cycle. The encoded protein binds to a D-type cyclin to form an active kinase complex to regulate progression through the G1 phase of the cell cycle. Mice lacking the encoded protein exhibit thymic and splenic hypoplasia, and hematopoietic defects such as reduced number of megakaryocytes and erythrocytes. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK154197.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans (By similarity). May play a role in the centrosome organization during the cell cycle phases. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Activated by Thr-177 phosphorylation and Tyr-24 dephosphorylation (By similarity). Rapidly down-regulated prior to cell differentiation (e.g. erythroid and osteoblast) (By similarity). Interaction with D-type G1 cyclins. Cyclin binding promotes enzyme activation by phosphorylation at Thr-177 (By similarity). Binds to RUNX1, CDKN2D, FBXO7 and CDKN2C/p18-INK4c. Forms a cytoplasmic complex with Hsp90/HSP90AB1 and CDC37. FBXO7-binding promotes D-type cyclin binding (By similarity). Q64261; P30282: Ccnd3; NbExp=2; IntAct=EBI-847380, EBI-847337; Q64261; P05627: Jun; NbExp=2; IntAct=EBI-847380, EBI-764369; Q64261; P42227: Stat3; NbExp=3; IntAct=EBI-847380, EBI-602878; Cytoplasm Nucleus Cell projection, ruffle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (By similarity). Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus. Expressed in subgranular zone (SGZ) of the hippocampal dentate gyrus (DG) and the subventricular zone (SVZ) of the lateral ventricles whose neural precursor cells (NPC) give rise to dentate granule neurons and olfactory bulb (OB) interneurons, respectively. Expressed in the neuroepithelium of the cerebral cortex of the developing brain. Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity. Slight anemia and defective proliferation of some hematopoietic cells, thymocytes and progenitor cells. Females are reduced in size and often sterile. Prevents the expansion of neuronally committed precursors by prematurely exiting the cell cycle and lengthening G1 phase duration, reducing concomitantly the production of newborn neurons. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. negative regulation of transcription from RNA polymerase II promoter nucleotide binding cyclin-dependent protein kinase holoenzyme complex ruffle positive regulation of cell-matrix adhesion hematopoietic progenitor cell differentiation type B pancreatic cell development protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm centrosome microtubule organizing center cytosol cytoskeleton protein phosphorylation cell cycle Notch signaling pathway response to virus regulation of gene expression positive regulation of gene expression kinase activity phosphorylation transferase activity hemopoiesis cell differentiation cyclin binding T cell differentiation in thymus gliogenesis regulation of cell proliferation cell projection cell dedifferentiation negative regulation of myeloid cell differentiation regulation of erythrocyte differentiation negative regulation of monocyte differentiation negative regulation of osteoblast differentiation negative regulation of cell cycle positive regulation of fibroblast proliferation negative regulation of epithelial cell proliferation cell division hematopoietic stem cell differentiation cyclin D2-CDK6 complex FBXO family protein binding regulation of hematopoietic stem cell differentiation negative regulation of cellular senescence uc008wgu.1 uc008wgu.2 uc008wgu.3 uc008wgu.4 
ENSMUST00000165125.8 Tmem9 ENSMUST00000165125.8 transmembrane protein 9, transcript variant 1 (from RefSeq NM_001160145.1) ENSMUST00000165125.1 ENSMUST00000165125.2 ENSMUST00000165125.3 ENSMUST00000165125.4 ENSMUST00000165125.5 ENSMUST00000165125.6 ENSMUST00000165125.7 NM_001160145 Q3U459 Q9CR23 TMEM9_MOUSE Tmem9 uc011wsv.1 uc011wsv.2 uc011wsv.3 Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (By similarity). By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (By similarity). TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC (PubMed:30374053, PubMed:32380568). In the liver, involved in hepatic regeneration (PubMed:32380568). Interacts with the v-ATPase accessory protein ATP6AP2 and with the v-ATPase complex subunit ATP6V0D1; these interactions lead to the assembly of the v-ATPase complex. Lysosome membrane ; Single-pass type I membrane protein Late endosome membrane ; Single-pass type I membrane protein Endosome, multivesicular body membrane ; Single-pass type I membrane protein Expressed in heart, lung, kidney, liver and intestines (PubMed:30374053). Enriched in the hepatocytes around the central vein (PubMed:32380568). The transmembrane domain (TMD) is essential for the interaction with ATP6AP2. N-glycosylated. Knockout mice are viable and exhibit no discernible phenotypes in the overall liver architecture and hepatocytes (PubMed:30374053, PubMed:32380568). However, they display impaired hepatic regeneration with reduced Wnt signaling (PubMed:32380568). Knockout mice also show a suppression of intestinal tumorigenesis (PubMed:30374053). Belongs to the TMEM9 family. molecular_function lysosome lysosomal membrane endosome late endosome biological_process membrane integral component of membrane late endosome membrane uc011wsv.1 uc011wsv.2 uc011wsv.3 
ENSMUST00000165128.9 Armh1 ENSMUST00000165128.9 armadillo-like helical domain containing 1 (from RefSeq NM_001145637.1) Armh1 E9Q963 E9Q963_MOUSE ENSMUST00000165128.1 ENSMUST00000165128.2 ENSMUST00000165128.3 ENSMUST00000165128.4 ENSMUST00000165128.5 ENSMUST00000165128.6 ENSMUST00000165128.7 ENSMUST00000165128.8 Gm1661 NM_001145637 uc008uig.1 uc008uig.2 uc008uig.3 uc008uig.4 molecular_function cellular_component biological_process uc008uig.1 uc008uig.2 uc008uig.3 uc008uig.4 
ENSMUST00000165133.3 Spata31d1b ENSMUST00000165133.3 spermatogenesis associated 31 subfamily D, member 1B (from RefSeq NM_001167593.1) E9QA57 E9QA57_MOUSE ENSMUST00000165133.1 ENSMUST00000165133.2 Fam75d1b NM_001167593 Spata31d1b uc007qva.1 uc007qva.2 uc007qva.3 Membrane ; Single- pass membrane protein Belongs to the SPATA31 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007qva.1 uc007qva.2 uc007qva.3 
ENSMUST00000165136.2 Gm8094 ENSMUST00000165136.2 Gm8094 (from geneSymbol) ENSMUST00000165136.1 Gm8094 K7N6U8 K7N6U8_MOUSE uc288sqv.1 uc288sqv.2 molecular_function cellular_component biological_process uc288sqv.1 uc288sqv.2 
ENSMUST00000165145.4 Gm17039 ENSMUST00000165145.4 predicted gene 17039 (from RefSeq NR_167764.1) ENSMUST00000165145.1 ENSMUST00000165145.2 ENSMUST00000165145.3 NR_167764 uc288oem.1 uc288oem.2 uc288oem.3 uc288oem.1 uc288oem.2 uc288oem.3 
ENSMUST00000165147.3 Muc5b ENSMUST00000165147.3 mucin 5, subtype B, tracheobronchial (from RefSeq NM_028801.2) E9Q5I3 E9Q5I3_MOUSE ENSMUST00000165147.1 ENSMUST00000165147.2 Muc5b NM_028801 uc009kmc.1 uc009kmc.2 uc009kmc.3 Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function extracellular region extracellular space defense response to bacterium regulation of macrophage activation intracellular membrane-bounded organelle uc009kmc.1 uc009kmc.2 uc009kmc.3 
ENSMUST00000165164.9 Pcgf1 ENSMUST00000165164.9 polycomb group ring finger 1, transcript variant 1 (from RefSeq NM_197992.2) ENSMUST00000165164.1 ENSMUST00000165164.2 ENSMUST00000165164.3 ENSMUST00000165164.4 ENSMUST00000165164.5 ENSMUST00000165164.6 ENSMUST00000165164.7 ENSMUST00000165164.8 NM_197992 Nspc1 PCGF1_MOUSE Q8R023 Rnf68 uc009cmg.1 uc009cmg.2 uc009cmg.3 Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells. Interacts with BCORL1, forming heterodimers (By similarity). The PCGF1-BCORL1 heterodimeric complex interacts with the KDM2B-SKP1 heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1) (By similarity). Component of the repressive BCOR complex containing a Polycomb group subcomplex at least composed of RYBP, RING1 and RNF2/RING2 (By similarity). Specifically interacts with BCOR, RING1 and RNF2/RING2 (By similarity). Component of a PRC1-like complex (By similarity). Interacts with CBX6, CBX7 and CBX8 (By similarity). Interacts with DPPA4, NANOG, POU5F1 and RYBP (By similarity). Nucleus Expressed in the otic vesicle, urogenital bud and dorsal root ganglia at 10.5 dpc, in the neural tube and neural crest cell derivatives of the peripheral nervous system at 11.5 dpc. Sequence=AAH28560.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter protein binding nucleus nucleoplasm chromatin silencing protein C-terminus binding PcG protein complex PRC1 complex histone H2A monoubiquitination histone H2A-K119 monoubiquitination metal ion binding promoter-specific chromatin binding uc009cmg.1 uc009cmg.2 uc009cmg.3 
ENSMUST00000165167.8 Sult2a4 ENSMUST00000165167.8 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 4 (from RefSeq NM_001101534.1) D3Z6M7 D3Z6M7_MOUSE D3Z6M8 ENSMUST00000165167.1 ENSMUST00000165167.2 ENSMUST00000165167.3 ENSMUST00000165167.4 ENSMUST00000165167.5 ENSMUST00000165167.6 ENSMUST00000165167.7 G3UWB5 NM_001101534 Sult2a4 Sult2a5 Sult2a7 uc012ezr.1 uc012ezr.2 This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849386, SAMN01164135 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## Belongs to the sulfotransferase 1 family. alcohol sulfotransferase activity cytoplasm cytosol drug binding sulfotransferase activity biological_process transferase activity bile-salt sulfotransferase activity steroid sulfotransferase activity 3'-phosphoadenosine 5'-phosphosulfate binding uc012ezr.1 uc012ezr.2 
ENSMUST00000165170.8 Cimip4 ENSMUST00000165170.8 ciliary microtubule inner protein 4, transcript variant 2 (from RefSeq NM_028522.1) CMIP4_MOUSE ENSMUST00000165170.1 ENSMUST00000165170.2 ENSMUST00000165170.3 ENSMUST00000165170.4 ENSMUST00000165170.5 ENSMUST00000165170.6 ENSMUST00000165170.7 Ean57 NM_028522 Q9D9J2 Tex33 uc007wpb.1 uc007wpb.2 uc007wpb.3 Seems to be associated with spermiogenesis but is not essential for sperm development and male fertility. Cytoplasmic vesicle, secretory vesicle, acrosome Cell projection, cilium, flagellum Only detected in testis, in the spermatids and sperm within the seminiferous tubules (at protein level). Initially expressed in the cytoplasm of round spermatids, expression diminishes in elongated spermatid (PubMed:28742876). Detected in testis at 28 days after birth and expression is maintained (PubMed:28742876, PubMed:33760102). Mutant adult male are fertile and there is no significant change on litter size compared with male wild-type adult. No differences are found in testis/body weight ratios, testicular/epididymal tissue morphology, sperm counts, sperm morphology and spermatozoa motility. molecular_function cellular_component biological_process uc007wpb.1 uc007wpb.2 uc007wpb.3 
ENSMUST00000165175.8 Sv2b ENSMUST00000165175.8 synaptic vesicle glycoprotein 2b, transcript variant 1 (from RefSeq NM_153579.4) ENSMUST00000165175.1 ENSMUST00000165175.2 ENSMUST00000165175.3 ENSMUST00000165175.4 ENSMUST00000165175.5 ENSMUST00000165175.6 ENSMUST00000165175.7 Kiaa0735 NM_153579 Q80TT1 Q8BG39 Q9ES95 SV2B_MOUSE uc009hwl.1 uc009hwl.2 uc009hwl.3 Probably plays a role in the control of regulated secretion in neural and endocrine cells. (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin probably binds via extracellular loop 4 (PubMed:16543415). (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD) (PubMed:21483489). Not a receptor for C.botulinum neurotoxin type D (BoNT/D, botD) (PubMed:21632541). (Microbial infection) Receptor for C.botulinum neurotoxin type E (BoNT/E); the toxin probably binds via extracellular loop 4 (PubMed:18815274). It probably requires glycosylation of Asn-516 (PubMed:18815274). Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25. (Microbial infection) Interacts with C.botulinum neurotoxin type A (BoNT/A, botA). (Microbial infection) Interacts with C.botulinum neurotoxin type D (BoNT/D, botD) (PubMed:21483489). No evidence for its interaction with BoNT/D has also been published (PubMed:21632541). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, acrosome Note=Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin- secreting cells of the pancreas (By similarity). Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity). Expressed in ribbon synapses of the retina (at protein level) (PubMed:12687700). Expressed in diaphragm motor nerve terminals (at protein level) (PubMed:16543415). Expressed in hippocampus neurons (at protein level) (PubMed:18815274). Expressed during synaptogenesis in the retina (at protein level). Up-regulated upon Sv2a depletion. N-glycosylated. The N-terminal cytoplasmic domain is phosphorylated by CK1. Mice display no particular phenotype (PubMed:10624962). Single knockout mice survive significantly longer than wild-type mice upon exposure to C.botulinum neurotoxin type A (BoNT/A, botA) (PubMed:16543415). Mice lacking both Sv2a and Sv2b experience severe epileptic seizures and die immediately or shortly after birth similarly to mice lacking only Sv2a (PubMed:10624962). Single knockout mice bind reduced amounts of BoNT/A than wild-type mice (PubMed:16543415). Single knockout mice are significantly more resistant to C.botulinum neurotoxin type E (BoNT/E) than wild-type mice (PubMed:18815274). In single knockout mice, synaptobrevin (VAMP, the target of C.botulinum neurotoxin type D, BoNT/D) is degraded by BoNT/D, and hippocampal neurons bind BoNT/D (PubMed:21483489). Hippocampal neurons from young mice lacking both Sv2a and Sv2b do not bind BoNT/A, nor do they take it up (PubMed:16543415, PubMed:18815274). Hippocampal neurons from young mice lacking both Sv2a and Sv2b do not bind C.botulinum neurotoxin type E (BoNT/E), nor do they take it up (PubMed:18815274). Hippocampal neurons from young mice lacking both Sv2a and Sv2b do not bind C.botulinum neurotoxin type D (BoNT/D, botD), nor do they take it up (PubMed:21483489). Hippocampal neurons from young mice lacking both Sv2a and Sv2b take up C.botulinum neurotoxin type C (BoNT/C) and C.botulinum neurotoxin type F (BonT/F, botF) normally (PubMed:21483489). Belongs to the major facilitator superfamily. The use of this protein as a coreceptor for C.botulinum type D (BoNT/D, botD) is controversial. In double SV2A/SV2B knockout mice BoNT/D does not degrade its synaptobrevin target; introducing SV2A, SV2B or SV2C restores target cleavage (PubMed:21483489). However another group does not find a convincing interaction with SV2 (PubMed:21632541). acrosomal vesicle integral component of plasma membrane neurotransmitter transport chemical synaptic transmission synaptic vesicle membrane integral component of membrane transmembrane transporter activity cell junction integral component of synaptic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle neuron projection synapse transmembrane transport uc009hwl.1 uc009hwl.2 uc009hwl.3 
ENSMUST00000165196.8 Gm38392 ENSMUST00000165196.8 Reaction=CO2(out) = CO2(in); Xref=Rhea:RHEA:74891, ChEBI:CHEBI:16526; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74892; Evidence=; (from UniProt E9Q2A2) AY254685 E9Q2A2 E9Q2A2_MOUSE ENSMUST00000165196.1 ENSMUST00000165196.2 ENSMUST00000165196.3 ENSMUST00000165196.4 ENSMUST00000165196.5 ENSMUST00000165196.6 ENSMUST00000165196.7 Gm38392 uc290gmc.1 uc290gmc.2 Reaction=CO2(out) = CO2(in); Xref=Rhea:RHEA:74891, ChEBI:CHEBI:16526; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74892; Evidence=; Reaction=NH4(+)(in) = NH4(+)(out); Xref=Rhea:RHEA:28747, ChEBI:CHEBI:28938; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28748; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28749; Evidence=; Reaction=methylamine(out) = methylamine(in); Xref=Rhea:RHEA:74391, ChEBI:CHEBI:59338; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74392; Evidence=; Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane. Basolateral cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Lateral cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. integral component of plasma membrane ammonium transmembrane transporter activity ammonium transport membrane integral component of membrane chaperone binding ammonium transmembrane transport uc290gmc.1 uc290gmc.2 
ENSMUST00000165199.8 Arsa ENSMUST00000165199.8 arylsulfatase A (from RefSeq NM_009713.4) ARSA_MOUSE As2 ENSMUST00000165199.1 ENSMUST00000165199.2 ENSMUST00000165199.3 ENSMUST00000165199.4 ENSMUST00000165199.5 ENSMUST00000165199.6 ENSMUST00000165199.7 NM_009713 P50428 Q9DC66 uc007xgy.1 uc007xgy.2 uc007xgy.3 uc007xgy.4 Hydrolyzes cerebroside sulfate. Reaction=H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate; Xref=Rhea:RHEA:21300, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:18390, ChEBI:CHEBI:75956; EC=3.1.6.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21301; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Homodimer at neutral pH and homooctamer at acidic pH. Exists both as a single chain of 58 kDa (component A) or as a chain of 50 kDa (component B) linked by disulfide bond(s) to a 7 kDa chain (component C). Interacts with SUMF1 (By similarity). Endoplasmic reticulum Lysosome The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post- translational modification is severely defective in multiple sulfatase deficiency (MSD). Belongs to the sulfatase family. acrosomal vesicle catalytic activity arylsulfatase activity cerebroside-sulfatase activity calcium ion binding extracellular space cytoplasm lysosome endosome endoplasmic reticulum plasma membrane autophagy binding of sperm to zona pellucida central nervous system development response to nutrient sulfuric ester hydrolase activity response to pH integral component of membrane hydrolase activity extrinsic component of external side of plasma membrane response to estrogen response to ethanol metal ion binding response to methylmercury uc007xgy.1 uc007xgy.2 uc007xgy.3 uc007xgy.4 
ENSMUST00000165200.2 Gm17191 ENSMUST00000165200.2 Gm17191 (from geneSymbol) ENSMUST00000165200.1 KY467646 uc288hos.1 uc288hos.2 uc288hos.1 uc288hos.2 
ENSMUST00000165201.9 Trps1 ENSMUST00000165201.9 transcriptional repressor GATA binding 1, transcript variant 2 (from RefSeq NM_032000.2) ENSMUST00000165201.1 ENSMUST00000165201.2 ENSMUST00000165201.3 ENSMUST00000165201.4 ENSMUST00000165201.5 ENSMUST00000165201.6 ENSMUST00000165201.7 ENSMUST00000165201.8 G3UW90 G3UW90_MOUSE NM_032000 Trps1 uc011zss.1 uc011zss.2 uc011zss.3 uc011zss.4 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated zinc ion binding sequence-specific DNA binding metal ion binding uc011zss.1 uc011zss.2 uc011zss.3 uc011zss.4 
ENSMUST00000165208.4 Mybpc2 ENSMUST00000165208.4 myosin binding protein C, fast-type (from RefSeq NM_146189.3) ENSMUST00000165208.1 ENSMUST00000165208.2 ENSMUST00000165208.3 MYPC2_MOUSE NM_146189 Q5XKE0 Q8C109 Q8K2V0 uc009gpv.1 uc009gpv.2 uc009gpv.3 uc009gpv.4 Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (By similarity). Belongs to the immunoglobulin superfamily. MyBP family. actin binding structural constituent of cytoskeleton cytoskeleton muscle contraction cytoskeleton organization cell adhesion myosin filament uc009gpv.1 uc009gpv.2 uc009gpv.3 uc009gpv.4 
ENSMUST00000165220.4 ENSMUSG00000121685 ENSMUST00000165220.4 ENSMUSG00000121685 (from geneSymbol) ENSMUST00000165220.1 ENSMUST00000165220.2 ENSMUST00000165220.3 EU233995 uc288kms.1 uc288kms.2 uc288kms.1 uc288kms.2 
ENSMUST00000165230.8 Zfp54 ENSMUST00000165230.8 zinc finger protein 54, transcript variant 4 (from RefSeq NM_001379358.1) E9PW05 ENSMUST00000165230.1 ENSMUST00000165230.2 ENSMUST00000165230.3 ENSMUST00000165230.4 ENSMUST00000165230.5 ENSMUST00000165230.6 ENSMUST00000165230.7 NM_001379358 O88631 Q66JT2 Q6R5P4 ZFP54_MOUSE Zfp54 uc012all.1 uc012all.2 uc012all.3 May be involved in transcriptional regulation. Nucleus Note=Shows widespread expression throughout the nucleus, but appears to be excluded from nucleoli. Expressed at high levels in testis, may also be expressed at low levels in heart, brain, and skeletal muscle. Expression is initially maternally contributed, with increased expression at the two-cell stage followed by significant decrease at the 4-cell stage, remaining consistently low through to the morula stage (PubMed:20624068). Elevated expression in early embryonic stage (7 days post coitum (dpc)) with decreased but consistent expression thereafter in whole embryos (PubMed:10384051). Increased expression at 20 dpc in testis, with lower but consistent expression thereafter (PubMed:10384051). Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAC29445.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAR91691.1; Type=Erroneous gene model prediction; Evidence=; nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc012all.1 uc012all.2 uc012all.3 
ENSMUST00000165231.8 Dlec1 ENSMUST00000165231.8 deleted in lung and esophageal cancer 1, transcript variant 1 (from RefSeq NM_177117.5) Dlec1 E9Q8C0 E9Q8C0_MOUSE ENSMUST00000165231.1 ENSMUST00000165231.2 ENSMUST00000165231.3 ENSMUST00000165231.4 ENSMUST00000165231.5 ENSMUST00000165231.6 ENSMUST00000165231.7 NM_177117 uc012hcj.1 uc012hcj.2 cytoplasm cytosol negative regulation of cell proliferation uc012hcj.1 uc012hcj.2 
ENSMUST00000165242.4 Eefsec ENSMUST00000165242.4 eukaryotic elongation factor, selenocysteine-tRNA-specific, transcript variant 26 (from RefSeq NR_177264.1) ENSMUST00000165242.1 ENSMUST00000165242.2 ENSMUST00000165242.3 NR_177264 Q6GTZ5 Q9JHW4 SELB_MOUSE Selb uc009cvg.1 uc009cvg.2 Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP. Cytoplasm Nucleus Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily. tRNA binding nucleotide binding selenocysteine incorporation translation elongation factor activity GTPase activity protein binding GTP binding nucleus cytoplasm mitochondrion cytosol translation translational elongation selenocysteine insertion sequence binding ribonucleoprotein complex binding ribonucleoprotein complex uc009cvg.1 uc009cvg.2 
ENSMUST00000165255.3 Vmn1r238 ENSMUST00000165255.3 vomeronasal 1 receptor, 238 (from RefSeq NM_001167539.1) E9Q373 E9Q373_MOUSE ENSMUST00000165255.1 ENSMUST00000165255.2 NM_001167539 Vmn1r238 uc008dxj.1 uc008dxj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc008dxj.1 uc008dxj.2 
ENSMUST00000165257.8 Tsku ENSMUST00000165257.8 tsukushi, small leucine rich proteoglycan, transcript variant 4 (from RefSeq NM_001168539.1) ENSMUST00000165257.1 ENSMUST00000165257.2 ENSMUST00000165257.3 ENSMUST00000165257.4 ENSMUST00000165257.5 ENSMUST00000165257.6 ENSMUST00000165257.7 Lrrc54 NM_001168539 Q4W655 Q8CBR6 TSK_MOUSE Tsk Tsku uc012fpr.1 uc012fpr.2 Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways (PubMed:21856951, PubMed:22995554, PubMed:25159578, PubMed:31391339). Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye (PubMed:21856951). Plays a role in regulating the hair cycle by controlling TGFB1 signaling (PubMed:22995554). Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth (PubMed:21055390, PubMed:23206892). Essential for terminal differentiation of hippocampal neural stem cells (PubMed:31983064). Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size (PubMed:30271858). Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells (PubMed:32127020). Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence (PubMed:25159578). Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver (PubMed:31391339). In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure (PubMed:31535079). In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis (PubMed:31767170). Interacts with FZD4 (via FZ domain); competes with WNT2B for binding to FZD4, inhibiting Wnt signaling and repressing peripheral eye development (PubMed:21856951). Interacts with TGFB1; the interaction contributes to regulation of the hair cycle (PubMed:22995554). Interacts with netrin (PubMed:23206892). Interacts with CCN2 (PubMed:30232710). Secreted Expressed in macrophages in inflamed wounds with wound expression starting 2 days post-wounding (dpw) (at protein level) (PubMed:25159578). At 7 dpw, expressed from epidermis and extracellular matrix in the wound edge to neoepidermis and granulation tissue and in panniculus carnosus under the granulation tissue (at protein level) (PubMed:25159578). After fibrosis, disappears in the dermal area at 11 dpw (at protein level) (PubMed:25159578). Expressed in the hair follicle during morphogenesis and the hair cycle (at protein level) (PubMed:22995554). In embryonic brain, strong expression in the olfactory bulb, anterior olfactory nucleus, neocortex, piriform cortex, glial wedge, midline zipper glia, indusium griseum and the area surrounding the anterior commissure (AC) but not on AC axons (at protein level) (PubMed:23206892). In the adult eye, expressed in retinal layers, lens epithelium, and ciliary body where it is expressed predominantly in the inner non-pigmented layer (PubMed:21856951). Expressed in almost all brain regions in the embryo, in the cortex and the lateral ventricle at P0 and is restricted to the subventricular zone and lateral nucleus of the amygdala in adults (PubMed:21055390). Prominent expression in hippocampal regions from early postnatal stages until postnatal day 15 and gradually declines at later stages (PubMed:31983064). Expressed in almost all bone regions in the femurs of juveniles (PubMed:30271858). In the inner ear, accumulates in nonprosensory regions during early embryonic stages and in both nonprosensory and prosensory regions in late embryonic stages (PubMed:32127020). In the adult ear, expressed in the organ of Corti, spiral ganglion cells, and the stria vascularis (PubMed:32127020). Highly expressed in the liver where it is detected primarily in hepatocytes but not in non-parenchymal cells (PubMed:31535079). During the hair cycle, expression is down- regulated at the first telogen stage and is up-regulated at the secondary anagen stage. By endoplasmic reticulum stress and inflammation (PubMed:31391339). Up-regulated in response to high-fat diet and this is reversed by return to a normal diet (PubMed:30595550, PubMed:31391339). Expansion of the ciliary body and up-regulation of Wnt2b and Fzd4 expression in the developing peripheral eye (PubMed:21856951). Delayed hair cycle with down-regulation of Tgfb1 throughout the cycle and low levels of phosphorylated Smad2/3 (PubMed:22995554). Failure of the axons of the anterior and posterior parts of the anterior commissure (AC) to cross the midline, leading to an almost total absence of the AC in adults (PubMed:21055390, PubMed:23206892). Reduced size of hippocampus and dentate gyrus (DG), increased number of neural stem cells (NSCs) in the DG at P15, altered ratio of proliferating and quiescent NSCs with an increase in the number of proliferating NSCs in the DG at P15, and abnormal terminal differentiation of NSCs (PubMed:31983064). Decreased weight and short stature due to decreased longitudinal bone growth coupled with low bone mass (PubMed:30271858). Shortened and morphologically abnormal growth plates and abnormal expression of chondrogenic marker genes (PubMed:30271858). Formation of abnormally short and dislocated stereocilia in the inner hair cells of the ear and hearing loss (PubMed:32127020). Reduced cochlear expression of Sox2 and translocation of Sox2 from the nucleus to the cytoplasm in spiral ganglion cells (SGCs) at P0 (PubMed:32127020). Redistribution of Bmp4 with diminished expression in the outer sulcus and sparse distribution around the cochlear epithelium (PubMed:32127020). Reduced number of SGCs at the cochlear basal turn (PubMed:32127020). Excess wound inflammation with up-regulation of Tgfb1, Stat3 and Il6 during wound healing (PubMed:25159578). Reduced body size, increased levels of circulating high-density lipoprotein cholesterol and increased cholesterol efflux (PubMed:31391339). Some studues showed increased sympathetic innervation and norepinephrine release in adipose tissue, leading to enhanced adrenergic signaling and thermogenesis, attenuation of brown fat whitening and protection from diet-induced obesity (PubMed:31535079, PubMed:30595550). Another study found no effect on brown fat thermogenic capacity, protection from diet-induced obesity or glucose homeostasis (PubMed:31767170). Double knockout of Tsku and Draxi results in a higher frequency of AC defects than single knockout of either Tsku or Draxi (PubMed:23206892). This factor is named 'Tsukushi' because its expression pattern in chick embryos is similar to the shape of the Japanese horsetail plant, tsukushi. Sequence=BAC29069.1; Type=Erroneous initiation; Evidence=; Sequence=BAE23270.1; Type=Erroneous initiation; Evidence=; protein binding extracellular region extracellular space regulation of gene expression corpus callosum morphogenesis lateral ventricle development anterior commissure morphogenesis negative regulation of Wnt signaling pathway extracellular matrix camera-type eye development ciliary body morphogenesis uc012fpr.1 uc012fpr.2 
ENSMUST00000165306.3 Gpank1 ENSMUST00000165306.3 G patch domain and ankyrin repeats 1, transcript variant 7 (from RefSeq NM_001410204.1) Bat4 ENSMUST00000165306.1 ENSMUST00000165306.2 Gpank1 NM_001410204 Q6PES3 Q6PES3_MOUSE uc008cfx.1 uc008cfx.2 uc008cfx.3 uc008cfx.4 nucleic acid binding uc008cfx.1 uc008cfx.2 uc008cfx.3 uc008cfx.4 
ENSMUST00000165307.8 Anp32e ENSMUST00000165307.8 acidic nuclear phosphoprotein 32 family member E, transcript variant 1 (from RefSeq NM_023210.4) AN32E_MOUSE Cpd1 E9Q5H9 ENSMUST00000165307.1 ENSMUST00000165307.2 ENSMUST00000165307.3 ENSMUST00000165307.4 ENSMUST00000165307.5 ENSMUST00000165307.6 ENSMUST00000165307.7 NM_023210 P97822 Q3TH89 Q3TX26 Q8BPF8 Q8C2L4 Q8C7Q8 Q9CZD2 uc008qlu.1 uc008qlu.2 uc008qlu.3 uc008qlu.4 Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. Component of a SWR1-like complex, composed of EP400, KAT5/TIP60, TRRAP, BRD8, RUVBL1, RUVBL2, ING3 and ANP32E; the complex does not contain SRCAP. Interacts with H2A.Z/H2AZ1 (By similarity). Interacts with the importin alpha KPNA1 and KPNA2. Cytoplasm. Nucleus. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P97822-1; Sequence=Displayed; Name=2; IsoId=P97822-2; Sequence=VSP_007373; Name=3; IsoId=P97822-3; Sequence=VSP_059599; Expressed at highest levels in cerebellum and spleen. In the cerebellum, expressed mainly in granule cells and, to a lesser extent, in Purkinje cells. Low levels are found at postnatal day 4. Levels increase from postnatal day 7 to postnatal day 17. Levels decrease and remain low in the adult. The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AZ1. Phosphorylated. The phosphorylation is nuclear localization signal (NLS)-dependent (By similarity). No visible phenotype. Mice are viable and fertile (PubMed:20844742, PubMed:21049064, PubMed:23675506). They display a subtle neurological clasping phenotype and mild motor deficits (PubMed:20844742). Motor defects were not confirmed by a subsequent analysis (PubMed:23675506). Deletion in embryonic fibroblasts results in the appearance of a significant number of new H2A.Z/H2AZ1 around the transcription start site as well as at other chromatin regions (PubMed:24463511). Belongs to the ANP32 family. Swr1 complex nucleus cytoplasm chromatin organization phosphatase inhibitor activity cytoplasmic vesicle histone binding negative regulation of catalytic activity histone exchange uc008qlu.1 uc008qlu.2 uc008qlu.3 uc008qlu.4 
ENSMUST00000165309.8 Pex2 ENSMUST00000165309.8 peroxisomal biogenesis factor 2, transcript variant 7 (from RefSeq NM_001163306.2) ENSMUST00000165309.1 ENSMUST00000165309.2 ENSMUST00000165309.3 ENSMUST00000165309.4 ENSMUST00000165309.5 ENSMUST00000165309.6 ENSMUST00000165309.7 NM_001163306 Pex2 Pxmp3 Q91YZ5 Q91YZ5_MOUSE uc033hsc.1 uc033hsc.2 uc033hsc.3 Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.; EC=2.3.2.36; Evidence=; Protein modification; protein ubiquitination. Membrane ; Multi- pass membrane protein Peroxisome membrane ; Multi-pass membrane protein Belongs to the pex2/pex10/pex12 family. very long-chain fatty acid metabolic process negative regulation of transcription from RNA polymerase II promoter peroxisome peroxisomal membrane integral component of peroxisomal membrane fatty acid beta-oxidation peroxisome organization membrane protein import into peroxisome matrix Cdc73/Paf1 complex protein destabilization metal ion binding negative regulation of fibroblast proliferation negative regulation of epithelial cell proliferation uc033hsc.1 uc033hsc.2 uc033hsc.3 
ENSMUST00000165310.3 Ms4a6c ENSMUST00000165310.3 membrane-spanning 4-domains, subfamily A, member 6C, transcript variant 1 (from RefSeq NM_028595.4) ENSMUST00000165310.1 ENSMUST00000165310.2 M4A6C_MOUSE NM_028595 Q3U8E1 Q8BVZ4 Q99N08 Q9D7Z9 uc008gsh.1 uc008gsh.2 uc008gsh.3 uc008gsh.4 uc008gsh.5 May be involved in signal transduction as a component of a multimeric receptor complex. Membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99N08-1; Sequence=Displayed; Name=2; IsoId=Q99N08-2; Sequence=VSP_007385, VSP_007386; Expressed only by thymus, spleen, peripheral lymph node and bone marrow. Belongs to the MS4A family. membrane integral component of membrane uc008gsh.1 uc008gsh.2 uc008gsh.3 uc008gsh.4 uc008gsh.5 
ENSMUST00000165311.3 Cnnm1 ENSMUST00000165311.3 cyclin M1, transcript variant 2 (from RefSeq NM_031396.3) Acdp1 CNNM1_MOUSE ENSMUST00000165311.1 ENSMUST00000165311.2 NM_031396 Q0GA42 Q9JIQ6 uc008hoh.1 uc008hoh.2 uc008hoh.3 uc008hoh.4 Probable metal transporter. Cell membrane ; Multi-pass membrane protein Predominantly expressed in brain and testis, and, at lower levels, in kidney. In the brain, expressed in hippocampal neurons (at protein level). Shares weak sequence similarity with the cyclin family, explaining its name. However, it has no cyclin-like function in vivo. Belongs to the ACDP family. Sequence=AAF86371.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAF86371.1; Type=Frameshift; Evidence=; plasma membrane ion transport membrane integral component of membrane transmembrane transporter activity dendrite neuronal cell body transmembrane transport uc008hoh.1 uc008hoh.2 uc008hoh.3 uc008hoh.4 
ENSMUST00000165316.8 Iars1 ENSMUST00000165316.8 isoleucyl-tRNA synthetase 1 (from RefSeq NM_172015.3) ENSMUST00000165316.1 ENSMUST00000165316.2 ENSMUST00000165316.3 ENSMUST00000165316.4 ENSMUST00000165316.5 ENSMUST00000165316.6 ENSMUST00000165316.7 Iars NM_172015 Q6NXK4 Q8BU30 SYIC_MOUSE uc007qjv.1 uc007qjv.2 uc007qjv.3 uc007qjv.4 Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Reaction=ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L- isoleucyl-tRNA(Ile); Xref=Rhea:RHEA:11060, Rhea:RHEA-COMP:9666, Rhea:RHEA-COMP:9695, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58045, ChEBI:CHEBI:78442, ChEBI:CHEBI:78528, ChEBI:CHEBI:456215; EC=6.1.1.5; Evidence=; Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18. Cytoplasm Cytoplasm, cytosol Belongs to the class-I aminoacyl-tRNA synthetase family. tRNA binding nucleotide binding aminoacyl-tRNA editing activity aminoacyl-tRNA ligase activity isoleucine-tRNA ligase activity ATP binding cytoplasm cytosol translation tRNA aminoacylation for protein translation isoleucyl-tRNA aminoacylation ligase activity aminoacyl-tRNA synthetase multienzyme complex GTPase binding uc007qjv.1 uc007qjv.2 uc007qjv.3 uc007qjv.4 
ENSMUST00000165318.4 Rbak ENSMUST00000165318.4 RB-associated KRAB zinc finger, transcript variant 1 (from RefSeq NM_021326.3) ENSMUST00000165318.1 ENSMUST00000165318.2 ENSMUST00000165318.3 NM_021326 Q6PB38 Q8BQC8 Q9JKU4 RBAK_MOUSE Znf769 uc009ajp.1 uc009ajp.2 uc009ajp.3 May repress E2F-dependent transcription. May promote AR- dependent transcription. Interacts with AR (By similarity). May also interact with other nuclear hormone receptors such as NR3C1/GR (By similarity). Interacts with RB1. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding nucleus nucleoplasm regulation of transcription, DNA-templated metal ion binding uc009ajp.1 uc009ajp.2 uc009ajp.3 
ENSMUST00000165320.3 Fiz1 ENSMUST00000165320.3 Flt3 interacting zinc finger protein 1, transcript variant 5 (from RefSeq NM_001360241.1) ENSMUST00000165320.1 ENSMUST00000165320.2 FIZ1_MOUSE NM_001360241 Q91W14 Q9CTG3 Q9WTJ4 uc009ezg.1 uc009ezg.2 uc009ezg.3 uc009ezg.4 May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with NRL (By similarity). Cytoplasm Nucleus Widely expressed. In the retina, highest expression in the ganglion cell layer. Expressed in the retina at 14.5 dpc. positive regulation of protein phosphorylation nucleic acid binding protein binding nucleus cytoplasm receptor tyrosine kinase binding metal ion binding uc009ezg.1 uc009ezg.2 uc009ezg.3 uc009ezg.4 
ENSMUST00000165330.3 Vmn1r91 ENSMUST00000165330.3 vomeronasal 1 receptor 91 (from RefSeq NM_001166736.1) E9PZR7 E9PZR7_MOUSE ENSMUST00000165330.1 ENSMUST00000165330.2 NM_001166736 Vmn1r91 uc012fbo.1 uc012fbo.2 uc012fbo.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fbo.1 uc012fbo.2 uc012fbo.3 
ENSMUST00000165335.8 Gnb1 ENSMUST00000165335.8 guanine nucleotide binding protein (G protein), beta 1, transcript variant 1 (from RefSeq NM_008142.5) ENSMUST00000165335.1 ENSMUST00000165335.2 ENSMUST00000165335.3 ENSMUST00000165335.4 ENSMUST00000165335.5 ENSMUST00000165335.6 ENSMUST00000165335.7 Gnb1 NM_008142 Q3TQ70 Q3TQ70_MOUSE uc008wdr.1 uc008wdr.2 uc008wdr.3 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Belongs to the WD repeat G protein beta family. photoreceptor inner segment GTPase activity heterotrimeric G-protein complex signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cardiac muscle cell apoptotic process dendrite spectrin binding photoreceptor outer segment membrane cell body macromolecular complex binding alkylglycerophosphoethanolamine phosphodiesterase activity GTPase binding cellular response to hypoxia uc008wdr.1 uc008wdr.2 uc008wdr.3 
ENSMUST00000165341.5 Otogl ENSMUST00000165341.5 otogelin-like, transcript variant 2 (from RefSeq NM_001370989.1) D3JEN5 ENSMUST00000165341.1 ENSMUST00000165341.2 ENSMUST00000165341.3 ENSMUST00000165341.4 F7A4A7 NM_001370989 OTOGL_MOUSE uc011xnc.1 uc011xnc.2 uc011xnc.3 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=F7A4A7-1; Sequence=Displayed; Name=2; IsoId=F7A4A7-2; Sequence=VSP_045177; At 17.5 dpc, primarily detected in the spiral prominence and the Claudius cells and weakly in hair cells (at protein level). Also detected in the lumen surface of interdental cells in the proximity of Reissner's membrane and at the base of nascent tectorial membrane (at protein level). Similar expression pattern in P0 cochlea, with additional detection in some supporting cells (at protein level). At the same stage, in saccule, weakly expressed in hair cells and more prominently in the saccular roof (at protein level). By P6, expression becomes more restricted. Mainly detected in the outer hair cells, Deiter's cells and Claudius cells (at protein level). In the tectorial membrane, localized to the base. In the saccule, detected at high levels in the saccule roof with little change in the hair cells (at protein level). Belongs to the otogelin family. molecular_function cellular_component extracellular region sensory perception of sound biological_process L-arabinose metabolic process alpha-L-arabinofuranosidase activity uc011xnc.1 uc011xnc.2 uc011xnc.3 
ENSMUST00000165350.8 Gm17066 ENSMUST00000165350.8 Gm17066 (from geneSymbol) AK005802 ENSMUST00000165350.1 ENSMUST00000165350.2 ENSMUST00000165350.3 ENSMUST00000165350.4 ENSMUST00000165350.5 ENSMUST00000165350.6 ENSMUST00000165350.7 uc007uxi.1 uc007uxi.2 uc007uxi.3 uc007uxi.4 uc007uxi.1 uc007uxi.2 uc007uxi.3 uc007uxi.4 
ENSMUST00000165365.3 Cd276 ENSMUST00000165365.3 CD276 antigen, transcript variant 3 (from RefSeq NM_133983.5) B7h3 CD276_MOUSE ENSMUST00000165365.1 ENSMUST00000165365.2 NM_133983 Q8VE98 uc009pxb.1 uc009pxb.2 uc009pxb.3 uc009pxb.4 Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone- immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T- cell dependent killing of tumor cells. Interacts with TREML2 and this interaction enhances T-cell activation. Q8VE98; Q8VE98: Cd276; NbExp=2; IntAct=EBI-16044767, EBI-16044767; Membrane ; Single-pass type I membrane protein Ubiquitous. Highly expressed in developing bones during embryogenesis and expression increases as osteoblast precursor cells differentiate into mature osteoblasts. Up-regulated in cells mediating rejection of mouse transplant. Mice display a lower bone mineral density in cortical bones with femurs more susceptible to bone fracture, but do not exhibit any important skeletal abnormalities. Calvarial cells reveal normal number of osteoblast precursor cells with adequate proliferative capacity, but have impaired osteogenic differentiation. Furthermore, following cardiac transplantation, they display permanent survival under rapamycin regimen and cardiac transplants also show markedly decreased production of key cytokine and chemokine. The incidence of chronic transplant rejection is also inhibited. Mice also develop more severe airway inflammation and experimental autoimmune encephalomyelitis earlier than wild-type littermates as well as accumulate higher concentrations of autoantibodies to DNA. Gene transfer of B7-H3 leads to complete regression of 50 per cent tumors, or significantly slows tumor growth. In primates, B7-H3 locus underwent genomic duplication leading to tandemly repeated immunoglobulin-like V and C domains (VC domains). The dominantly expressed human B7-H3 isoform contains tandemly duplicated VC domains. In contrast, mouse B7-H3 transcript contains only one single VC domain form due to an exon structure corresponding to V domain-(pseudoexon C)-(pseudoexon V)-C domain. This duplication appearing in primates is suggested to be very recent supporting a model of multiple independent emergence of tandem VC repeats within human and monkey species. Belongs to the immunoglobulin superfamily. BTN/MOG family. receptor binding external side of plasma membrane membrane integral component of membrane positive regulation of bone mineralization positive regulation of T cell proliferation T cell activation negative regulation of T cell proliferation identical protein binding negative regulation of interferon-gamma biosynthetic process positive regulation of interferon-gamma biosynthetic process negative regulation of interleukin-2 biosynthetic process positive regulation of osteoblast differentiation negative regulation of inflammatory response regulation of immune response T cell receptor signaling pathway positive regulation of interleukin-2 secretion uc009pxb.1 uc009pxb.2 uc009pxb.3 uc009pxb.4 
ENSMUST00000165379.8 Or10ad1c ENSMUST00000165379.8 olfactory receptor family 10 subfamily AD member 1C (from RefSeq NM_001011733.2) E9Q1P2 E9Q1P2_MOUSE ENSMUST00000165379.1 ENSMUST00000165379.2 ENSMUST00000165379.3 ENSMUST00000165379.4 ENSMUST00000165379.5 ENSMUST00000165379.6 ENSMUST00000165379.7 Gm44579 NM_001011733 Olfr288 Or10ad1c uc007xma.1 uc007xma.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: BG080619.2, DR065616.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007xma.1 uc007xma.2 
ENSMUST00000165386.2 Ccdc152 ENSMUST00000165386.2 coiled-coil domain containing 152, transcript variant 1 (from RefSeq NM_001166063.3) Ccdc152 E9PX14 E9PX14_MOUSE ENSMUST00000165386.1 NM_001166063 uc011zqs.1 uc011zqs.2 molecular_function cellular_component biological_process uc011zqs.1 uc011zqs.2 
ENSMUST00000165408.8 Baiap2l2 ENSMUST00000165408.8 BAI1-associated protein 2-like 2 (from RefSeq NM_177580.3) BI2L2_MOUSE ENSMUST00000165408.1 ENSMUST00000165408.2 ENSMUST00000165408.3 ENSMUST00000165408.4 ENSMUST00000165408.5 ENSMUST00000165408.6 ENSMUST00000165408.7 NM_177580 Q3UP58 Q80Y61 uc007wtb.1 uc007wtb.2 uc007wtb.3 Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide. Q80Y61-1; Q80Y61-1: Baiap2l2; NbExp=3; IntAct=EBI-15935597, EBI-15935597; Cell membrane ; Peripheral membrane protein Cell junction Cytoplasmic vesicle membrane Note=Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80Y61-1; Sequence=Displayed; Name=2; IsoId=Q80Y61-2; Sequence=VSP_021325, VSP_021326; Expressed in the epithelial layer of the intestine and in the kidney. The IMD domain consisting of an antiparallel dimer of three- helix bundles, featuring on one side a positively charged. The N- terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation. phospholipid binding nucleoplasm cytosol plasma membrane plasma membrane organization lipid binding vesicle membrane actin cytoskeleton membrane cell junction cytoplasmic vesicle membrane positive regulation of actin filament polymerization cytoplasmic vesicle identical protein binding cell-cell contact zone actin filament bundle assembly actin crosslink formation membrane organization clathrin complex positive regulation of actin cytoskeleton reorganization uc007wtb.1 uc007wtb.2 uc007wtb.3 
ENSMUST00000165413.9 Stk35 ENSMUST00000165413.9 serine/threonine kinase 35, transcript variant 1 (from RefSeq NM_183262.3) A2ANF2 ENSMUST00000165413.1 ENSMUST00000165413.2 ENSMUST00000165413.3 ENSMUST00000165413.4 ENSMUST00000165413.5 ENSMUST00000165413.6 ENSMUST00000165413.7 ENSMUST00000165413.8 NM_183262 Q3TMD8 Q80ZW0 Q8BIC2 STK35_MOUSE Stk35l1 uc008mie.1 uc008mie.2 uc008mie.3 uc008mie.4 uc008mie.5 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts with PDLIM1/CLP-36. Nucleus. Nucleus, nucleolus. Cytoplasm. Note=When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers. Autophosphorylated. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Sequence=AAI38905.1; Type=Erroneous initiation; Evidence=; Sequence=AAI38906.1; Type=Erroneous initiation; Evidence=; Sequence=BAC25152.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC25152.1; Type=Frameshift; Evidence=; Sequence=BAE38504.1; Type=Erroneous initiation; Evidence=; Sequence=CAM22106.1; Type=Erroneous initiation; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleolus cytoplasm protein phosphorylation kinase activity phosphorylation nuclear body transferase activity uc008mie.1 uc008mie.2 uc008mie.3 uc008mie.4 uc008mie.5 
ENSMUST00000165418.9 Zfp148 ENSMUST00000165418.9 zinc finger protein 148, transcript variant 3 (from RefSeq NM_011749.4) ENSMUST00000165418.1 ENSMUST00000165418.2 ENSMUST00000165418.3 ENSMUST00000165418.4 ENSMUST00000165418.5 ENSMUST00000165418.6 ENSMUST00000165418.7 ENSMUST00000165418.8 NM_011749 P97475 Q61624 ZN148_MOUSE Zbp89 Znf148 uc007zab.1 uc007zab.2 uc007zab.3 Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. Interacts with HNRNPDL (By similarity). Interacts with the 5FMC complex; the interaction requires association with CHTOP (PubMed:22872859). Interacts with CAVIN1 (PubMed:10727401). Nucleus. Strong expression detected in brain, lung, liver and kidney, with lower levels detected in spleen, skeletal muscle, testis and heart. Detected in embryos from 7 dpc to 17 dpc. Expression decreases in developing skeletal muscles. Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm Golgi apparatus gamete generation negative regulation of gene expression sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding macromolecular complex assembly uc007zab.1 uc007zab.2 uc007zab.3 
ENSMUST00000165443.4 Nup50 ENSMUST00000165443.4 nucleoporin 50 (from RefSeq NM_016714.2) ENSMUST00000165443.1 ENSMUST00000165443.2 ENSMUST00000165443.3 NM_016714 NUP50_MOUSE Npap60 Q3TG43 Q3TN17 Q6P1F4 Q6PAL4 Q8C2Y6 Q9CU02 Q9JIH2 Q9JK85 uc007xcq.1 uc007xcq.2 uc007xcq.3 Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:10811608). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling (PubMed:16222336). Interacts with regulatory proteins of cell cycle progression including CDKN1B (PubMed:10891500, PubMed:10811608). This interaction is required for correct intracellular transport and degradation of CDKN1B (PubMed:10811608). Does not interact with TPR (By similarity). Interacts with Importin alpha-2, Importin beta, Importin beta-2, NUP153, Ran binding protein 7, CDKN1B and itself. Nucleus, nuclear pore complex. Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex. Dissociates from the NPC structure early during prophase of mitosis. Associates with the newly formed nuclear membrane during telophase. In the testis, the localization changes during germ cell differentiation from the nuclear surface in spermatocytes to the whole nucleus (interior) in spermatids and back to the nuclear surface in spermatozoa. Widely expressed at low levels. Highest in the developing neural tube and adult testes. Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. NUP50 targeted disruption results in a complex phenotype characterized by neural tube defects, exencephaly, intrauterine growth retardation, and late embryonic lethality. neural tube formation protein binding nucleus nuclear pore nucleoplasm protein import into nucleus protein transport membrane nuclear membrane intracellular membrane-bounded organelle intracellular transport mRNA transport ribonucleoprotein complex uc007xcq.1 uc007xcq.2 uc007xcq.3 
ENSMUST00000165454.3 ENSMUSG00000091585 ENSMUST00000165454.3 PRAME family member 8-like (from RefSeq NM_001412541.1) ENSMUST00000165454.1 ENSMUST00000165454.2 NM_001412541 uc291cfq.1 uc291cfq.2 uc291cfq.1 uc291cfq.2 
ENSMUST00000165458.3 Gm17477 ENSMUST00000165458.3 Gm17477 (from geneSymbol) ENSMUST00000165458.1 ENSMUST00000165458.2 uc292jcz.1 uc292jcz.2 uc292jcz.1 uc292jcz.2 
ENSMUST00000165460.2 Whamm ENSMUST00000165460.2 WAS protein homolog associated with actin, golgi membranes and microtubules, transcript variant 7 (from RefSeq NR_185079.1) ENSMUST00000165460.1 Kiaa1971 NR_185079 Q571B6 Q80VK9 Q80YT0 Q8BJP8 WHAMM_MOUSE Whdc1 uc012fny.1 uc012fny.2 Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin- nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration (By similarity). Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Interacts with ACTR3; indicative for an association with the ARP2/3 complex. Associates with microtubules; in vitro binds to tubulin heterodimer in a 1:1 stoichiometry; decorates microtubules with a repeat of 80 A along protofilaments. Interacts with RHOD (in GTP-bound form). Cytoplasm Endoplasmic reticulum-Golgi intermediate compartment Cytoplasmic vesicle membrane Golgi apparatus, cis-Golgi network Note=Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q571B6-1; Sequence=Displayed; Name=2; IsoId=Q571B6-2; Sequence=VSP_026722, VSP_026729; The N-terminal region associates with membranes, the coiled- coil region binds to microtubules and the WH2 domains promotes actin nucleation. Sequence=AAH42749.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; Sequence=BAC38074.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; Sequence=BAD90198.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane actin binding cytoplasm endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cytosol microtubule ER to Golgi vesicle-mediated transport actin filament organization cell cycle arrest microtubule binding membrane GTP-Rho binding lamellipodium assembly cytoplasmic vesicle membrane cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment membrane Arp2/3 complex-mediated actin nucleation focal adhesion assembly positive regulation of actin nucleation Arp2/3 complex binding actin filament reorganization plasma membrane tubulation uc012fny.1 uc012fny.2 
ENSMUST00000165466.8 2610042L04Rik ENSMUST00000165466.8 RIKEN cDNA 2610042L04 gene (from RefSeq NM_001309398.1) 2610042L04Rik ENSMUST00000165466.1 ENSMUST00000165466.2 ENSMUST00000165466.3 ENSMUST00000165466.4 ENSMUST00000165466.5 ENSMUST00000165466.6 ENSMUST00000165466.7 NM_001309398 Q9D073 Q9D073_MOUSE uc007sbq.1 uc007sbq.2 uc007sbq.3 uc007sbq.4 uc007sbq.5 negative regulation of protein phosphorylation protein binding cellular_component synapse assembly regulation of mitochondrion organization regulation of synaptic activity uc007sbq.1 uc007sbq.2 uc007sbq.3 uc007sbq.4 uc007sbq.5 
ENSMUST00000165470.9 Slc6a2 ENSMUST00000165470.9 Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:16269905). Can also mediate sodium- and chloride-dependent transport of dopamine (By similarity). (from UniProt O55192) AY188506 ENSMUST00000165470.1 ENSMUST00000165470.2 ENSMUST00000165470.3 ENSMUST00000165470.4 ENSMUST00000165470.5 ENSMUST00000165470.6 ENSMUST00000165470.7 ENSMUST00000165470.8 O55192 Q6QU62 SC6A2_MOUSE uc292cbo.1 uc292cbo.2 Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:16269905). Can also mediate sodium- and chloride-dependent transport of dopamine (By similarity). Reaction=(R)-noradrenaline(out) + chloride(out) + Na(+)(out) = (R)- noradrenaline(in) + chloride(in) + Na(+)(in); Xref=Rhea:RHEA:70923, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:72587; Evidence=; Reaction=chloride(out) + dopamine(out) + Na(+)(out) = chloride(in) + dopamine(in) + Na(+)(in); Xref=Rhea:RHEA:70919, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:59905; Evidence=; Reaction=chloride(out) + dopamine(out) + 2 Na(+)(out) = chloride(in) + dopamine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70931, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:59905; Evidence=; Kinetic parameters: KM=98 nM for noradrenaline in inbred long-sleep mice ; KM=89.1 nM for noradrenaline in inbred short-sleep mice ; Interacts with PRKCABP. Cell membrane ; Multi-pass membrane protein This protein is the target of psychomotor stimulants such as amphetamines or cocaine. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily. actin binding neurotransmitter:sodium symporter activity dopamine:sodium symporter activity norepinephrine:sodium symporter activity plasma membrane integral component of plasma membrane neurotransmitter transport monoamine transmembrane transporter activity cell surface symporter activity monoamine transport norepinephrine transport membrane integral component of membrane neuronal cell body membrane response to drug presynaptic membrane neuron projection alpha-tubulin binding membrane raft metal ion binding response to pain beta-tubulin binding dopamine uptake involved in synaptic transmission norepinephrine uptake transmembrane transport neurotransmitter reuptake uc292cbo.1 uc292cbo.2 
ENSMUST00000165495.2 Zfp764l1 ENSMUST00000165495.2 zinc finger protein 764 like 1 (from RefSeq NM_198011.2) E430018J23Rik E9PZQ8 E9PZQ8_MOUSE ENSMUST00000165495.1 NM_198011 uc012fud.1 uc012fud.2 uc012fud.3 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc012fud.1 uc012fud.2 uc012fud.3 
ENSMUST00000165499.2 Gm17324 ENSMUST00000165499.2 predicted gene, 17324 (from RefSeq NR_188921.1) ENSMUST00000165499.1 NR_188921 uc292jar.1 uc292jar.2 uc292jar.1 uc292jar.2 
ENSMUST00000165512.4 Mnx1 ENSMUST00000165512.4 motor neuron and pancreas homeobox 1 (from RefSeq NM_019944.2) A2RSX2 A2RSX2_MOUSE ENSMUST00000165512.1 ENSMUST00000165512.2 ENSMUST00000165512.3 Mnx1 NM_019944 uc008wuk.1 uc008wuk.2 uc008wuk.3 uc008wuk.4 Nucleus DNA binding nucleus nucleolus cytosol regulation of transcription, DNA-templated sequence-specific DNA binding uc008wuk.1 uc008wuk.2 uc008wuk.3 uc008wuk.4 
ENSMUST00000165532.3 Rpl14 ENSMUST00000165532.3 ribosomal protein L14 (from RefSeq NM_025974.3) ENSMUST00000165532.1 ENSMUST00000165532.2 NM_025974 Q9CR57 Q9D8Q1 RL14_MOUSE uc009scr.1 uc009scr.2 uc009scr.3 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Cytoplasm Belongs to the eukaryotic ribosomal protein eL14 family. RNA binding structural constituent of ribosome ribosome rRNA processing translation postsynaptic density cytosolic large ribosomal subunit ribosomal large subunit biogenesis uc009scr.1 uc009scr.2 uc009scr.3 
ENSMUST00000165536.8 Klf3 ENSMUST00000165536.8 Kruppel-like transcription factor 3 (basic), transcript variant 2 (from RefSeq NR_165035.1) Bklf ENSMUST00000165536.1 ENSMUST00000165536.2 ENSMUST00000165536.3 ENSMUST00000165536.4 ENSMUST00000165536.5 ENSMUST00000165536.6 ENSMUST00000165536.7 KLF3_MOUSE NR_165035 Q60980 uc008xms.1 uc008xms.2 uc008xms.3 Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis. Monomer. Nucleus In 8.5 day embryos, expressed in midbrain, anterior hindbrain and ventral forebrain. In 9 day embryos, expressed throughout ventral anterior half of embryo including midbrain-hindbrain junction, ventral midbrain, diencephalon and forebrain. At 10.5 days, distribution is more widespread with expression also found in developing limb buds. Widely expressed in the adult. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF3, the motif is inactive. Sumoylated with SUMO1. Sumoylation is enhanced by PIAS1, PIAS2alpha and PIAS2beta, and PIAS4, but not by Pc2. Enhances transcriptional repression, but has no effect on DNA binding. Sumoylation on Lys-197 is the major site. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter metal ion binding cellular response to peptide uc008xms.1 uc008xms.2 uc008xms.3 
ENSMUST00000165541.8 Ptp4a3 ENSMUST00000165541.8 protein tyrosine phosphatase 4a3, transcript variant 3 (from RefSeq NM_001166389.2) ENSMUST00000165541.1 ENSMUST00000165541.2 ENSMUST00000165541.3 ENSMUST00000165541.4 ENSMUST00000165541.5 ENSMUST00000165541.6 ENSMUST00000165541.7 NM_001166389 O70275 Prl3 Q3T9Z5 Q9CTC8 Q9D658 TP4A3_MOUSE uc011ztw.1 uc011ztw.2 Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine. Interacts with tubulin. Cell membrane. Early endosome. Present in the small intestine, where it is located in the differentiated epithelial cells of the villus but not in the proliferating crypt cells (at protein level). Expressed in heart and skeletal muscle, and at lower levels in lung, spleen and testis. Down-regulated upon skeletal muscle denervation. Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus. Belongs to the protein-tyrosine phosphatase family. phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm endosome early endosome plasma membrane regulation of transcription, DNA-templated protein dephosphorylation Notch signaling pathway membrane dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation positive regulation of vascular permeability endothelial cell migration regulation of vascular endothelial growth factor signaling pathway positive regulation of NIK/NF-kappaB signaling positive regulation of establishment of protein localization cellular response to leukemia inhibitory factor uc011ztw.1 uc011ztw.2 
ENSMUST00000165559.3 Ctif ENSMUST00000165559.3 CBP80/20-dependent translation initiation factor, transcript variant 4 (from RefSeq NM_201354.3) Ctif E9Q1U6 E9Q1U6_MOUSE ENSMUST00000165559.1 ENSMUST00000165559.2 NM_201354 uc008fqg.1 uc008fqg.2 uc008fqg.3 uc008fqg.4 uc008fqg.5 uc008fqg.6 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay RNA binding cytosol regulation of translational initiation perinuclear region of cytoplasm uc008fqg.1 uc008fqg.2 uc008fqg.3 uc008fqg.4 uc008fqg.5 uc008fqg.6 
ENSMUST00000165561.4 Smim13 ENSMUST00000165561.4 small integral membrane protein 13 (from RefSeq NM_001135577.2) E9Q942 ENSMUST00000165561.1 ENSMUST00000165561.2 ENSMUST00000165561.3 NM_001135577 SIM13_MOUSE uc007qfc.1 uc007qfc.2 uc007qfc.3 Membrane ; Single-pass membrane protein Belongs to the SMIM13 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007qfc.1 uc007qfc.2 uc007qfc.3 
ENSMUST00000165563.8 Micu1 ENSMUST00000165563.8 mitochondrial calcium uptake 1, transcript variant 3 (from RefSeq NM_144822.3) Cbara1 ENSMUST00000165563.1 ENSMUST00000165563.2 ENSMUST00000165563.3 ENSMUST00000165563.4 ENSMUST00000165563.5 ENSMUST00000165563.6 ENSMUST00000165563.7 MICU1_MOUSE NM_144822 Q8BK07 Q8BL84 Q8R1W0 Q8VCX5 uc007fdx.1 uc007fdx.2 uc007fdx.3 uc007fdx.4 Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:24560927). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (By similarity). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (By similarity). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (By similarity). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (By similarity). Homohexamer; in absence of calcium (By similarity). Forms a homohexamer in absence of calcium and rearranges into a heterodimer in presence of calcium (By similarity). Heterodimer; disulfide-linked; heterodimerizes with MICU2 (PubMed:23409044, PubMed:24560927). The heterodimer formed with MICU2 associates with MCU at low calcium concentration and dissociates from MCU at high calcium level (By similarity). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1 (By similarity). Interacts (via polybasic region) with EMRE/SMDT1; the interaction is direct (By similarity). Interacts (via polybasic region) with MCU (via coiled coil domains); the interaction is direct and precedes formation of the heterodimer with MICU2 (PubMed:23409044). Interacts with SLC25A23 (By similarity). Interacts with CHCHD4/MIA40; which introduces the interchain disulfide bond with MICU2 (By similarity). Mitochondrion inner membrane ; Single-pass membrane protein Mitochondrion intermembrane space Note=The topology is subject to debate. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VCX5-1; Sequence=Displayed; Name=2; IsoId=Q8VCX5-2; Sequence=VSP_031982; Name=3; IsoId=Q8VCX5-3; Sequence=VSP_031983; Expressed in skeletal muscle, heart, kidney, liver, brain, lung, fat and spleen. The EF-hand domains have high affinity for calcium and act as sensors of mitochondrial matrix calcium levels. The C-helix is required for assembling the Ca(2+)-free homohexamer. It also plays a key role in mitochondrial calcium uptake, probably by mediating interaction with MICU2. The EF-hand domains have high affinity for calcium and act as sensors of calcium levels. Lethality during the first hours after birth: embryos are at the expected Mendelian ratio and death takes place only after birth. Belongs to the MICU1 family. MICU1 subfamily. calcium ion binding protein binding mitochondrion mitochondrial inner membrane mitochondrial intermembrane space ion transport calcium ion transport mitochondrial calcium ion transport membrane integral component of membrane integral component of mitochondrial membrane calcium channel complex mitochondrial calcium uptake identical protein binding metal ion binding protein heterodimerization activity protein homooligomerization mitochondrial calcium ion homeostasis positive regulation of mitochondrial calcium ion concentration calcium ion import regulation of cellular hyperosmotic salinity response uniplex complex uc007fdx.1 uc007fdx.2 uc007fdx.3 uc007fdx.4 
ENSMUST00000165576.8 Fam3c ENSMUST00000165576.8 FAM3 metabolism regulating signaling molecule C (from RefSeq NM_138587.4) D6Wsu176e ENSMUST00000165576.1 ENSMUST00000165576.2 ENSMUST00000165576.3 ENSMUST00000165576.4 ENSMUST00000165576.5 ENSMUST00000165576.6 ENSMUST00000165576.7 FAM3C_MOUSE Ilei NM_138587 Q53YY7 Q7TML1 Q91VU0 Q9CTB4 uc009bay.1 uc009bay.2 uc009bay.3 May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. Secreted Cytoplasmic vesicle Ubiquitously expressed, with highest levels in the retina. Up-regulated in mammary epithelial cells and hepatocytes undergoing epithelial to mesenchymal transition (at protein level). Expressed at 15.5 dpc in the nonsensory epithelium of the inner ear and at lower levels in the vestibule of the inner ear, the brain and hair follicles. Expressed in the ganglion cell layer of the retina and in the ciliary body at 15.5 dpc. At later stages, retinal expression becomes restricted to the ganglion cell layer. By TGF-beta in epithelial cells. Belongs to the FAM3 family. molecular_function extracellular region extracellular space Golgi apparatus multicellular organism development biological_process cytoplasmic vesicle negative regulation of gluconeogenesis uc009bay.1 uc009bay.2 uc009bay.3 
ENSMUST00000165580.3 Krtap27-1 ENSMUST00000165580.3 keratin associated protein 27-1 (from RefSeq NM_001163105.2) E9PX37 E9PX37_MOUSE ENSMUST00000165580.1 ENSMUST00000165580.2 Krtap27-1 NM_001163105 uc012aht.1 uc012aht.2 uc012aht.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the PMG family. molecular_function cellular_component biological_process uc012aht.1 uc012aht.2 uc012aht.3 
ENSMUST00000165591.4 Pate11 ENSMUST00000165591.4 prostate and testis expressed 11 (from RefSeq NM_001128510.2) 671003 B3GLJ6 B3GLJ6_MOUSE ENSMUST00000165591.1 ENSMUST00000165591.2 ENSMUST00000165591.3 Gm9513 NM_001128510 Pate11 uc012gqv.1 uc012gqv.2 uc012gqv.3 cellular_component acetylcholine receptor regulator activity regulation of neurotransmitter receptor activity uc012gqv.1 uc012gqv.2 uc012gqv.3 
ENSMUST00000165594.4 Septin7 ENSMUST00000165594.4 septin 7, transcript variant 1 (from RefSeq NM_009859.4) E9Q1G8 E9Q1G8_MOUSE ENSMUST00000165594.1 ENSMUST00000165594.2 ENSMUST00000165594.3 NM_009859 Sept7 Septin7 uc033jjq.1 uc033jjq.2 uc033jjq.3 Filament-forming cytoskeletal GTPase. Septins polymerize into heterooligomeric protein complexes that form filaments. Cell projection, cilium, flagellum Chromosome, centromere, kinetochore Cleavage furrow Cytoplasm, cytoskeleton, cilium axoneme Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. nucleotide binding GTP binding septin complex uc033jjq.1 uc033jjq.2 uc033jjq.3 
ENSMUST00000165607.9 Senp6 ENSMUST00000165607.9 SUMO/sentrin specific peptidase 6, transcript variant 1 (from RefSeq NM_001311110.1) ENSMUST00000165607.1 ENSMUST00000165607.2 ENSMUST00000165607.3 ENSMUST00000165607.4 ENSMUST00000165607.5 ENSMUST00000165607.6 ENSMUST00000165607.7 ENSMUST00000165607.8 F6Z9A1 F6Z9A1_MOUSE NM_001311110 Senp6 uc009qvd.1 uc009qvd.2 uc009qvd.3 uc009qvd.4 uc009qvd.5 Belongs to the peptidase C48 family. nucleoplasm cytosol proteolysis cysteine-type peptidase activity protein desumoylation SUMO-specific endopeptidase activity protein modification by small protein removal regulation of spindle assembly regulation of kinetochore assembly uc009qvd.1 uc009qvd.2 uc009qvd.3 uc009qvd.4 uc009qvd.5 
ENSMUST00000165610.3 AU040972 ENSMUST00000165610.3 expressed sequence AU040972 (from RefSeq NR_045305.1) ENSMUST00000165610.1 ENSMUST00000165610.2 NR_045305 uc029rmx.1 uc029rmx.2 uc029rmx.3 uc029rmx.4 uc029rmx.1 uc029rmx.2 uc029rmx.3 uc029rmx.4 
ENSMUST00000165611.2 Vmn2r48 ENSMUST00000165611.2 vomeronasal 2, receptor 48 (from RefSeq NM_001105152.1) E9Q5D8 E9Q5D8_MOUSE ENSMUST00000165611.1 NM_001105152 Vmn2r48 uc012eym.1 uc012eym.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012eym.1 uc012eym.2 
ENSMUST00000165628.9 Taf5l ENSMUST00000165628.9 TATA-box binding protein associated factor 5 like, transcript variant 1 (from RefSeq NM_133966.3) ENSMUST00000165628.1 ENSMUST00000165628.2 ENSMUST00000165628.3 ENSMUST00000165628.4 ENSMUST00000165628.5 ENSMUST00000165628.6 ENSMUST00000165628.7 ENSMUST00000165628.8 NM_133966 Paf65b Q8BTL5 Q91WQ5 TAF5L_MOUSE Taf5l uc009nwx.1 uc009nwx.2 uc009nwx.3 uc009nwx.4 uc009nwx.5 Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (By similarity). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (PubMed:31005419). The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 (By similarity). Nucleus Belongs to the WD repeat TAF5 family. transcription coactivator activity histone acetyltransferase activity nucleus regulation of transcription, DNA-templated nuclear speck STAGA complex transcription factor TFTC complex cytoplasmic ribonucleoprotein granule histone H3 acetylation positive regulation of nucleic acid-templated transcription regulation of somatic stem cell population maintenance uc009nwx.1 uc009nwx.2 uc009nwx.3 uc009nwx.4 uc009nwx.5 
ENSMUST00000165630.3 Tom1 ENSMUST00000165630.3 target of myb1 trafficking protein, transcript variant 1 (from RefSeq NM_011622.4) ENSMUST00000165630.1 ENSMUST00000165630.2 NM_011622 Q561M4 Q561M4_MOUSE Tom1 uc009mha.1 uc009mha.2 uc009mha.3 uc009mha.4 Belongs to the TOM1 family. cell intracellular protein transport protein transport uc009mha.1 uc009mha.2 uc009mha.3 uc009mha.4 
ENSMUST00000165649.4 Ghitm ENSMUST00000165649.4 growth hormone inducible transmembrane protein, transcript variant 1 (from RefSeq NM_078478.5) ENSMUST00000165649.1 ENSMUST00000165649.2 ENSMUST00000165649.3 GHITM_MOUSE Mics1 NM_078478 Q3TGB7 Q3UA74 Q8N9T5 Q91VC9 uc007tby.1 uc007tby.2 uc007tby.3 uc007tby.4 uc007tby.5 uc007tby.6 Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:35715207). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Functions also as an electroneutral mitochondrial proton/potassium exchanger (PubMed:35715207). Required for the mitochondrial tubular network and cristae organization (PubMed:35715207). Involved in apoptotic release of cytochrome c (By similarity). Inhibits AFG3L2 proteolytic activity, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (By similarity). However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome (By similarity). Reaction=Ca(2+)(in) + 2 H(+)(out) = Ca(2+)(out) + 2 H(+)(in); Xref=Rhea:RHEA:72199, ChEBI:CHEBI:15378, ChEBI:CHEBI:29108; Evidence=; Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out); Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103; Evidence=; Interacts with LETM1 and AFG3L2. Mitochondrion inner membrane ; Multi-pass membrane protein By growth hormone. Undergoes AFG3L2-mediated proteolytic degradation, upon hyperpolarization of mitochondria. Belongs to the BI1 family. mitochondrion mitochondrial inner membrane apoptotic process membrane integral component of membrane uc007tby.1 uc007tby.2 uc007tby.3 uc007tby.4 uc007tby.5 uc007tby.6 
ENSMUST00000165651.8 Gucy1b2 ENSMUST00000165651.8 guanylate cyclase 1, soluble, beta 2, transcript variant 2 (from RefSeq NM_001204340.1) E9Q6H0 E9Q6H0_MOUSE ENSMUST00000165651.1 ENSMUST00000165651.2 ENSMUST00000165651.3 ENSMUST00000165651.4 ENSMUST00000165651.5 ENSMUST00000165651.6 ENSMUST00000165651.7 Gucy1b2 NM_001204340 uc011znh.1 uc011znh.2 uc011znh.3 uc011znh.4 Cytoplasm Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding guanylate cyclase activity cGMP biosynthetic process cyclic nucleotide biosynthetic process lyase activity phosphorus-oxygen lyase activity cGMP-mediated signaling heme binding intracellular signal transduction ion binding uc011znh.1 uc011znh.2 uc011znh.3 uc011znh.4 
ENSMUST00000165665.9 Arhgef12 ENSMUST00000165665.9 Rho guanine nucleotide exchange factor 12, transcript variant 1 (from RefSeq NM_027144.2) Arhgef12 ENSMUST00000165665.1 ENSMUST00000165665.2 ENSMUST00000165665.3 ENSMUST00000165665.4 ENSMUST00000165665.5 ENSMUST00000165665.6 ENSMUST00000165665.7 ENSMUST00000165665.8 F8VQN6 F8VQN6_MOUSE NM_027144 uc009pba.1 uc009pba.2 uc009pba.3 Cytoplasm Membrane G-protein coupled receptor binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity cytoplasm G-protein coupled receptor signaling pathway Rho protein signal transduction regulation of Rho protein signal transduction intracellular signal transduction positive regulation of GTPase activity uc009pba.1 uc009pba.2 uc009pba.3 
ENSMUST00000165666.9 Minar2 ENSMUST00000165666.9 membrane integral NOTCH2 associated receptor 2, transcript variant 3 (from RefSeq NM_173759.5) A0A0R4J0Q0 E9Q5J6 ENSMUST00000165666.1 ENSMUST00000165666.2 ENSMUST00000165666.3 ENSMUST00000165666.4 ENSMUST00000165666.5 ENSMUST00000165666.6 ENSMUST00000165666.7 ENSMUST00000165666.8 MNARL_MOUSE Minar2 NM_173759 Q6DI98 Q8C4X7 uc012bdg.1 uc012bdg.2 uc012bdg.3 uc012bdg.4 Binds cholesterol and may regulate the distribution and homeostasis of cholesterol in hair cells (By similarity). May play a role in angiogenesis (By similarity). Interacts with NOTCH2. Lysosome membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein Note=Localizes to the stereocilia and the apical region of hair cell, apparently around and just below the cuticular plate. Co- localized with cholesterol in the stereocilia. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C4X7-1; Sequence=Displayed; Name=2; IsoId=Q8C4X7-2; Sequence=VSP_059939; Widely expressed in the cortex and Purkinje cells of cerebellum (PubMed:32954300). Expressed in the inner ear, mainly in the hair cells, spiral ganglia, the spiral limbus, and the stria vascularis (PubMed:35727972). In an experimental Parkinson's disease model, homozygous knockout mice lacking Minar2 display severe motor deficits such as rigidity and bradykinesia, gait abnormalities, reduced spontaneous locomotor and exploratory behavior (PubMed:32954300). Homozygous knockout mice lacking Minar2 present with rapidly progressive sensorineural hearing loss (HL) associated with a reduction in outer hair cell stereocilia in the shortest row and degeneration of hair cells at a later age (PubMed:35727972). Belongs to the MINAR family. molecular_function cellular_component biological_process membrane integral component of membrane uc012bdg.1 uc012bdg.2 uc012bdg.3 uc012bdg.4 
ENSMUST00000165676.2 Gm17024 ENSMUST00000165676.2 Gm17024 (from geneSymbol) ENSMUST00000165676.1 KY467637 uc288gbm.1 uc288gbm.2 uc288gbm.1 uc288gbm.2 
ENSMUST00000165679.8 Rnf43 ENSMUST00000165679.8 ring finger protein 43, transcript variant 1 (from RefSeq NM_172448.4) B2KGH3 ENSMUST00000165679.1 ENSMUST00000165679.2 ENSMUST00000165679.3 ENSMUST00000165679.4 ENSMUST00000165679.5 ENSMUST00000165679.6 ENSMUST00000165679.7 NM_172448 Q5NCP0 Q6DI76 Q8BME0 Q8C191 Q8K0X4 RNF43_MOUSE uc007kue.1 uc007kue.2 uc007kue.3 uc007kue.4 E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with AKAP8L, NONO and SFPQ. Interacts with FZD5 (By similarity). Identified in a complex composed of RNF43, LGR5 and RSPO1 (By similarity). Interacts with RSPO2 (By similarity). Interacts with LMBR1L (PubMed:31073040). Cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum membrane ; Single-pass type I membrane protein Nucleus envelope Note=May be secreted. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5NCP0-1; Sequence=Displayed; Name=2; IsoId=Q5NCP0-2; Sequence=VSP_023203; Name=3; IsoId=Q5NCP0-3; Sequence=VSP_023204, VSP_023205; Expressed in crypt base columnar cells of small intestinal epithelium. Crypt base columnar cells are small cycling cells residing between the terminally differentiated Paneth cells at crypt bottoms. Colocalizes with Lgr5-positive stem cells. At 14.5 dpc, in the developing limb, expressed only in the ectoderm and, in developing lungs, detected in the epithelium. Autoubiquitinated. Conditional knockout mice lacking both Rnf43 and Znrf3 in intestine show a marked expansion of the proliferative compartment, resembling the effects of acute deletion of Apc. Belongs to the ZNRF3 family. ubiquitin-protein transferase activity frizzled binding nucleus nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane ubiquitin-dependent protein catabolic process multicellular organism development membrane integral component of membrane Wnt signaling pathway protein ubiquitination transferase activity negative regulation of Wnt signaling pathway Wnt receptor catabolic process metal ion binding ubiquitin protein ligase activity stem cell proliferation uc007kue.1 uc007kue.2 uc007kue.3 uc007kue.4 
ENSMUST00000165680.2 Gm17509 ENSMUST00000165680.2 predicted gene, 17509 (from RefSeq NR_188751.1) ENSMUST00000165680.1 NR_188751 uc288qds.1 uc288qds.2 uc288qds.1 uc288qds.2 
ENSMUST00000165687.3 Tmem207 ENSMUST00000165687.3 transmembrane protein 207 (from RefSeq NM_001101640.1) ENSMUST00000165687.1 ENSMUST00000165687.2 NM_001101640 P86045 TM207_MOUSE Tmem207 uc012adv.1 uc012adv.2 uc012adv.3 Interacts with WWOX. Membrane ; Single-pass type I membrane protein Sequence=AK142524; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; cellular_component biological_process membrane integral component of membrane enzyme binding uc012adv.1 uc012adv.2 uc012adv.3 
ENSMUST00000165713.8 Gm8279 ENSMUST00000165713.8 Gm8279 (from geneSymbol) ENSMUST00000165713.1 ENSMUST00000165713.2 ENSMUST00000165713.3 ENSMUST00000165713.4 ENSMUST00000165713.5 ENSMUST00000165713.6 ENSMUST00000165713.7 Gm8279 L7N2C6 L7N2C6_MOUSE uc288qll.1 uc288qll.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qll.1 uc288qll.2 
ENSMUST00000165721.8 Csnk1a1 ENSMUST00000165721.8 casein kinase 1, alpha 1, transcript variant 4 (from RefSeq NM_001357500.1) ENSMUST00000165721.1 ENSMUST00000165721.2 ENSMUST00000165721.3 ENSMUST00000165721.4 ENSMUST00000165721.5 ENSMUST00000165721.6 ENSMUST00000165721.7 KC1A_MOUSE NM_001357500 Q3UIL0 Q64506 Q80XI2 Q8BK63 Q99LY3 uc008fce.1 uc008fce.2 uc008fce.3 Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (By similarity). Can phosphorylate a large number of proteins (By similarity). Participates in Wnt signaling (By similarity). Phosphorylates CTNNB1 at 'Ser-45' (By similarity). May phosphorylate PER1 and PER2 (PubMed:21930935). May play a role in segregating chromosomes during mitosis (By similarity). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (By similarity). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34615873). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Interacts with the Axin complex (By similarity). Interacts with TUT1, leading to TUT1 phosphorylation (By similarity). Interacts with FAM83H; recruits CSNK1A1 to keratin filaments (By similarity). Interacts with FAM83D (via N-terminus); in mitotic cells (By similarity). Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Chromosome, centromere, kinetochore Nucleus speckle Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, spindle Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BK63-1; Sequence=Displayed; Name=2; IsoId=Q8BK63-2; Sequence=VSP_010252; Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. nucleotide binding magnesium ion binding chromosome, centromeric region kinetochore condensed chromosome kinetochore cell morphogenesis protein kinase activity protein serine/threonine kinase activity ATP binding nucleus chromosome cytoplasm centrosome microtubule organizing center cytosol mRNA cleavage and polyadenylation specificity factor complex cytoskeleton cilium protein phosphorylation Golgi organization cell cycle Wnt signaling pathway kinase activity phosphorylation nuclear speck transferase activity peptidyl-serine phosphorylation beta-catenin destruction complex positive regulation of proteasomal ubiquitin-dependent protein catabolic process ciliary basal body peptide binding cell projection keratin filament intermediate filament cytoskeleton organization phosphoprotein binding cell division negative regulation of canonical Wnt signaling pathway regulation of GTP binding ribonucleoprotein complex uc008fce.1 uc008fce.2 uc008fce.3 
ENSMUST00000165735.9 Acp5 ENSMUST00000165735.9 acid phosphatase 5, tartrate resistant, transcript variant 1 (from RefSeq NM_001102405.1) ENSMUST00000165735.1 ENSMUST00000165735.2 ENSMUST00000165735.3 ENSMUST00000165735.4 ENSMUST00000165735.5 ENSMUST00000165735.6 ENSMUST00000165735.7 ENSMUST00000165735.8 NM_001102405 PPA5_MOUSE Q05117 T5ap Trap uc009oob.1 uc009oob.2 uc009oob.3 May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 2 iron ions per subunit.; Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s). Lysosome. Characteristic constituent of osteoclasts. Induced by TNFSF11/RANKL-stimulation of bone marrow-derived macrophages. ossification acid phosphatase activity lysosome ferrous iron binding ferric iron binding dephosphorylation hydrolase activity response to lipopolysaccharide negative regulation of interleukin-1 beta production negative regulation of interleukin-12 production negative regulation of tumor necrosis factor production negative regulation of superoxide anion generation response to cytokine negative regulation of nitric oxide biosynthetic process bone resorption metal ion binding negative regulation of inflammatory response defense response to Gram-positive bacterium bone morphogenesis uc009oob.1 uc009oob.2 uc009oob.3 
ENSMUST00000165764.8 Cyp27b1 ENSMUST00000165764.8 cytochrome P450, family 27, subfamily b, polypeptide 1 (from RefSeq NM_010009.2) CP27B_MOUSE Cyp27b Cyp40 ENSMUST00000165764.1 ENSMUST00000165764.2 ENSMUST00000165764.3 ENSMUST00000165764.4 ENSMUST00000165764.5 ENSMUST00000165764.6 ENSMUST00000165764.7 NM_010009 O35084 uc007hht.1 uc007hht.2 uc007hht.3 uc007hht.4 A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1-alpha position to form the hormonally active form of vitamin D3, 1alpha,25- dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR) (PubMed:15972816, PubMed:10092858). Has 1-alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway. Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2 (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:15972816, PubMed:10092858). Reaction=calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:20573, Rhea:RHEA- COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17823, ChEBI:CHEBI:17933, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; EC=1.14.15.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20574; Evidence=; Reaction=2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:49064, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:28818, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:47799; EC=1.14.15.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49065; Evidence=; Reaction=25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:49068, Rhea:RHEA-COMP:9998, Rhea:RHEA- COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:47805, ChEBI:CHEBI:47812; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49069; Evidence=; Reaction=25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:49048, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:86319, ChEBI:CHEBI:86320; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49049; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Activated by cardiolipin and dioleoyl phosphatidylethanolamine (DOPE), phospholipids found in the inner mitochondrial membrane. Inhibited by high substrate concentration. Kinetic parameters: KM=2.7 uM for 25-hydroxyvitamin D3 ; KM=1.3 uM for 24,25-dihydroxyvitamin D3 ; KM=0.28 uM for 25-hydroxyvitamin D3 ; Vmax=9.5 pmol/min/mg enzyme with 25-hydroxyvitamin D3 as substrate ; Vmax=16.7 pmol/min/mg enzyme with 24,25-dihydroxyvitamin D3 as substrate ; Hormone biosynthesis; vitamin D biosynthesis. Mitochondrion membrane. Kidney. Belongs to the cytochrome P450 family. Sequence=BAA22434.1; Type=Erroneous initiation; Evidence=; monooxygenase activity calcidiol 1-monooxygenase activity iron ion binding cytoplasm mitochondrion calcium ion transport aging negative regulation of cell proliferation negative regulation of calcidiol 1-monooxygenase activity positive regulation of vitamin D 24-hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding bone mineralization negative regulation of cell growth regulation of bone mineralization mitochondrial membrane response to lipopolysaccharide response to insulin response to vitamin D response to interferon-gamma response to prostaglandin E calcitriol biosynthetic process from calciol vitamin D metabolic process vitamin D catabolic process response to drug response to estrogen positive regulation of keratinocyte differentiation response to copper ion decidualization metal ion binding response to cAMP calcium ion homeostasis oxidation-reduction process G1 to G0 transition positive regulation of vitamin D receptor signaling pathway uc007hht.1 uc007hht.2 uc007hht.3 uc007hht.4 
ENSMUST00000165774.8 Gbp2 ENSMUST00000165774.8 guanylate binding protein 2 (from RefSeq NM_010260.1) ENSMUST00000165774.1 ENSMUST00000165774.2 ENSMUST00000165774.3 ENSMUST00000165774.4 ENSMUST00000165774.5 ENSMUST00000165774.6 ENSMUST00000165774.7 GBP2_MOUSE Gbp2 NM_010260 Q4FK03 Q8CIC6 Q921N2 Q9R1I0 Q9Z0E6 uc008roy.1 uc008roy.2 uc008roy.3 Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:18025219, PubMed:24739961, PubMed:24715728, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30062052). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24739961, PubMed:24715728, PubMed:25774715, PubMed:25774716). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24739961, PubMed:24715728, PubMed:25774715, PubMed:25774716). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double- stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24739961, PubMed:24715728, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30062052). Confers protection to the protozoan pathogen Toxoplasma gondii (PubMed:18025219). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity by inhibiting FURIN-mediated maturation of viral envelope proteins (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; Homodimer; homodimerization occurs upon GTP-binding and is required for the association with membranous structures (By similarity). Heterodimer with other family members, including GBP1, GBP3, GBP4 and GBP5 (By similarity). Cytoplasmic vesicle membrane ; Lipid- anchor Golgi apparatus membrane ; Lipid-anchor Cytoplasm Cytoplasm, perinuclear region Note=GBP2-GBP5 dimers localize to the Golgi apparatus. By IFNG/IFN-gamma and IFNB1/IFN-beta (PubMed:9862701, PubMed:18025219). Up-regulated upon infection by T.gondii or L.monocytogenes (PubMed:18025219). By IRF1 in response to bacterial infection (PubMed:25774715). Isoprenylation is required for proper subcellular location. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily. Golgi membrane nucleotide binding GTPase activity GTP binding nucleus nucleoplasm cytoplasm Golgi apparatus cytosol response to bacterium actin cytoskeleton membrane hydrolase activity symbiont-containing vacuole membrane cytoplasmic vesicle protein localization to nucleus cellular response to interferon-beta protein homodimerization activity defense response to protozoan adhesion of symbiont to host perinuclear region of cytoplasm defense response to Gram-positive bacterium cellular response to lipopolysaccharide cellular response to interferon-gamma uc008roy.1 uc008roy.2 uc008roy.3 
ENSMUST00000165790.9 Klhl22 ENSMUST00000165790.9 kelch-like 22, transcript variant 8 (from RefSeq NR_166418.1) D3YW27 ENSMUST00000165790.1 ENSMUST00000165790.2 ENSMUST00000165790.3 ENSMUST00000165790.4 ENSMUST00000165790.5 ENSMUST00000165790.6 ENSMUST00000165790.7 ENSMUST00000165790.8 KLH22_MOUSE Klhl22 NR_166418 Q8BT13 Q99JN2 uc007ymc.1 uc007ymc.2 uc007ymc.3 uc007ymc.4 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation (By similarity). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys- 48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid- dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy (PubMed:29769719). Protein modification; protein ubiquitination. Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1. Interacts with PLK1. Interacts with DEPDC5 (via DEP domain); the interaction depends on amino acid availability. Interacts with YWHAE; required for the nuclear localization of KLHL22 upon amino acid starvation. Cytoplasm, cytosol Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Nucleus Lysosome Note=Mainly cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase. Localizes to the nucleus upon amino acid starvation. Relocalizes to the cytosol and associates with lysosomes when amino acids are available. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99JN2-1; Sequence=Displayed; Name=2; IsoId=Q99JN2-2; Sequence=VSP_019452; mitotic sister chromatid segregation nucleus cytoplasm lysosome centrosome microtubule organizing center spindle polar microtubule cytosol cytoskeleton protein monoubiquitination cell cycle mitotic spindle assembly checkpoint negative regulation of autophagy protein ubiquitination positive regulation of cell growth Cul3-RING ubiquitin ligase complex proteasome-mediated ubiquitin-dependent protein catabolic process cell division cellular response to amino acid stimulus cellular response to leucine 14-3-3 protein binding mitotic spindle positive regulation of TORC1 signaling uc007ymc.1 uc007ymc.2 uc007ymc.3 uc007ymc.4 
ENSMUST00000165806.8 Katna1 ENSMUST00000165806.8 Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. (from UniProt E9PZI6) AK041900 E9PZI6 E9PZI6_MOUSE ENSMUST00000165806.1 ENSMUST00000165806.2 ENSMUST00000165806.3 ENSMUST00000165806.4 ENSMUST00000165806.5 ENSMUST00000165806.6 ENSMUST00000165806.7 KATNA1 Katna1 uc007eii.1 uc007eii.2 uc007eii.3 Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence=; ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1. Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches. Cytoplasm, cytoskeleton, spindle Cytoplasm Midbody Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole te=Predominantly cytoplasmic. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase and telophase is localized at the midbody region. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1. Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis. The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization. Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation. Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation. Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. nucleotide binding spindle pole ATP binding cytoplasm centrosome microtubule organizing center spindle cytoskeleton microtubule cell cycle microtubule binding microtubule-severing ATPase activity isomerase activity midbody protein heterodimerization activity microtubule severing cell division mitotic spindle pole uc007eii.1 uc007eii.2 uc007eii.3 
ENSMUST00000165813.4 Scgb1b19 ENSMUST00000165813.4 secretoglobin, family 1B, member 19 (from RefSeq NM_001281526.1) Abpa19 ENSMUST00000165813.1 ENSMUST00000165813.2 ENSMUST00000165813.3 F6WYW0 F6WYW0_MOUSE Gm4695 NM_001281526 Scgb1b19 uc033iys.1 uc033iys.2 uc033iys.3 Secreted steroid binding extracellular region biological_process uc033iys.1 uc033iys.2 uc033iys.3 
ENSMUST00000165814.2 Gm9603 ENSMUST00000165814.2 Gm9603 (from geneSymbol) ENSMUST00000165814.1 Gm3542 Gm9603 K7N6U2 K7N6U2_MOUSE uc288qmt.1 uc288qmt.2 membrane integral component of membrane uc288qmt.1 uc288qmt.2 
ENSMUST00000165824.3 2810459M11Rik ENSMUST00000165824.3 RIKEN cDNA 2810459M11 gene, transcript variant 1 (from RefSeq NM_001144992.1) B2RPZ8 CB072_MOUSE ENSMUST00000165824.1 ENSMUST00000165824.2 NM_001144992 Q9CYS6 uc007bux.1 uc007bux.2 uc007bux.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CYS6-1; Sequence=Displayed; Name=2; IsoId=Q9CYS6-2; Sequence=VSP_040798; Sequence=BAB28812.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding cellular_component biological_process uc007bux.1 uc007bux.2 uc007bux.3 
ENSMUST00000165829.4 Rtl9 ENSMUST00000165829.4 retrotransposon Gag like 9 (from RefSeq NM_001040434.2) ENSMUST00000165829.1 ENSMUST00000165829.2 ENSMUST00000165829.3 Gm385 Kiaa1318 NM_001040434 Q32KG4 Q5DTY8 RTL9_MOUSE Rgag1 Rtl9 uc009umd.1 uc009umd.2 uc009umd.3 uc009umd.4 uc009umd.5 uc009umd.6 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q32KG4-1; Sequence=Displayed; Name=2; IsoId=Q32KG4-2; Sequence=VSP_021488; RTL8C is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. molecular_function cellular_component biological_process uc009umd.1 uc009umd.2 uc009umd.3 uc009umd.4 uc009umd.5 uc009umd.6 
ENSMUST00000165834.4 Vmn2r80 ENSMUST00000165834.4 vomeronasal 2, receptor 80 (from RefSeq NM_001103368.1) E9Q1L0 E9Q1L0_MOUSE ENSMUST00000165834.1 ENSMUST00000165834.2 ENSMUST00000165834.3 NM_001103368 Vmn2r80 uc009uzz.1 uc009uzz.2 uc009uzz.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009uzz.1 uc009uzz.2 uc009uzz.3 
ENSMUST00000165838.9 Metrn ENSMUST00000165838.9 meteorin, glial cell differentiation regulator (from RefSeq NM_133719.2) ENSMUST00000165838.1 ENSMUST00000165838.2 ENSMUST00000165838.3 ENSMUST00000165838.4 ENSMUST00000165838.5 ENSMUST00000165838.6 ENSMUST00000165838.7 ENSMUST00000165838.8 Hyrac METRN_MOUSE NM_133719 Q45G31 Q6P6N6 Q8C1Q4 Q8CI64 Q922A8 uc008bbz.1 uc008bbz.2 uc008bbz.3 Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. Monomer. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C1Q4-1; Sequence=Displayed; Name=2; IsoId=Q8C1Q4-2; Sequence=VSP_010844, VSP_010845; Highly expressed in brain. Expressed in undifferentiated neural progenitors and in astrocyte lineage, particularly in Bergmann glia, a subtype of radial glia, and a few discrete neuronal populations residing in the superior colliculus, the ocular motor nucleus, the raphe and pontine nuclei, and in various thalamic nuclei. Weakly expressed in heart, kidney, skeletal muscle, spleen, testis, gut and lung. By all-trans retinoic acid (ATRA). Was called meteorin because it can transform glial cells into cells with an elongated trail. Belongs to the meteorin family. Sequence=AAH37181.1; Type=Erroneous initiation; Evidence=; hormone activity extracellular region extracellular space signal transduction multicellular organism development nervous system development glial cell differentiation cell differentiation positive regulation of axonogenesis uc008bbz.1 uc008bbz.2 uc008bbz.3 
ENSMUST00000165848.10 Zscan4-ps1 ENSMUST00000165848.10 Chromosome, telomere Nucleus (from UniProt A0A1C7CYV3) A0A1C7CYV3 A0A1C7CYV3_MOUSE A0A916LM20 ENSMUST00000165848.1 ENSMUST00000165848.2 ENSMUST00000165848.3 ENSMUST00000165848.4 ENSMUST00000165848.5 ENSMUST00000165848.6 ENSMUST00000165848.7 ENSMUST00000165848.8 ENSMUST00000165848.9 Zscan4-ps1 uc291lkb.1 uc291lkb.2 Chromosome, telomere Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc291lkb.1 uc291lkb.2 
ENSMUST00000165859.8 Nemp2 ENSMUST00000165859.8 nuclear envelope integral membrane protein 2, transcript variant 2 (from RefSeq NR_024590.1) ENSMUST00000165859.1 ENSMUST00000165859.2 ENSMUST00000165859.3 ENSMUST00000165859.4 ENSMUST00000165859.5 ENSMUST00000165859.6 ENSMUST00000165859.7 NEMP2_MOUSE NR_024590 Q8C844 Q8CB65 Tmem194b uc011wkp.1 uc011wkp.2 uc011wkp.3 Nucleus inner membrane ; Multi-pass membrane protein ; Nucleoplasmic side Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CB65-1; Sequence=Displayed; Name=2; IsoId=Q8CB65-2; Sequence=VSP_033359, VSP_033360; In the ovary, highly expressed in somatic cells. Belongs to the NEMP family. molecular_function nucleus nuclear envelope nuclear inner membrane biological_process membrane integral component of membrane uc011wkp.1 uc011wkp.2 uc011wkp.3 
ENSMUST00000165885.2 Gm17023 ENSMUST00000165885.2 Gm17023 (from geneSymbol) ENSMUST00000165885.1 uc291yhv.1 uc291yhv.2 uc291yhv.1 uc291yhv.2 
ENSMUST00000165911.2 Gm17218 ENSMUST00000165911.2 Gm17218 (from geneSymbol) ENSMUST00000165911.1 uc289iqg.1 uc289iqg.2 uc289iqg.1 uc289iqg.2 
ENSMUST00000165916.2 Vmn1r149 ENSMUST00000165916.2 vomeronasal 1 receptor 149 (from RefSeq NM_001166840.1) E9PWL6 E9PWL6_MOUSE ENSMUST00000165916.1 NM_001166840 Vmn1r149 uc012fdz.1 uc012fdz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fdz.1 uc012fdz.2 
ENSMUST00000165921.2 Vmn2r33 ENSMUST00000165921.2 vomeronasal 2, receptor 33 (from RefSeq NM_001105065.2) ENSMUST00000165921.1 K7N705 K7N705_MOUSE NM_001105065 Vmn2r33 uc012exu.1 uc012exu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012exu.1 uc012exu.2 
ENSMUST00000165952.9 Lats1 ENSMUST00000165952.9 large tumor suppressor (from RefSeq NM_010690.1) B2RY46 ENSMUST00000165952.1 ENSMUST00000165952.2 ENSMUST00000165952.3 ENSMUST00000165952.4 ENSMUST00000165952.5 ENSMUST00000165952.6 ENSMUST00000165952.7 ENSMUST00000165952.8 LATS1_MOUSE Lats1 NM_010690 Q8BYR2 Q9Z0W4 Warts uc007eig.1 uc007eig.2 uc007eig.3 uc007eig.4 Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:21145499). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down- regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Complexes with CDK1 in early mitosis (By similarity). LATS1- associated CDK1 has no mitotic cyclin partner and no apparent kinase activity (By similarity). Binds phosphorylated ZYX, locating this protein to the mitotic spindle and suggesting a role for actin regulatory proteins during mitosis (By similarity). Binds to and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis (By similarity). Interacts (via PPxY motif 2) with YAP1 (via WW domains) (By similarity). Interacts with MOB1A and MOB1B. Interacts with LIMD1, WTIP and AJUBA (By similarity). Interacts with ESR1, DCAF1 and DCAF13; probably recruits DCAF1 and DCAF13 to ESR1 to promote ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation (By similarity). Interacts with STK3/MST2; this interaction is inhibited in the presence of DLG5 (By similarity). Interacts with SCRIB in the presence of DLG5 (By similarity). Interacts with WWTR1/TAZ (PubMed:21145499). Interacts with WWC1, WWC2 and WWC3 (via their WW domains) (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Midbody Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. Autophosphorylated and phosphorylated during M-phase of the cell cycle (By similarity). Phosphorylated by STK3/MST2 at Ser-908 and Thr- 1078, which results in its activation (By similarity). Phosphorylation at Ser-463 by NUAK1 and NUAK2 leads to decreased protein level and is required to regulate cellular senescence and cellular ploidy (By similarity). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle nucleotide binding mitotic cell cycle magnesium ion binding sister chromatid segregation spindle pole inner cell mass cell fate commitment inner cell mass cellular morphogenesis protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm microtubule organizing center spindle cytoskeleton protein phosphorylation cell cycle hormone-mediated signaling pathway kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation protein kinase binding keratinocyte differentiation estrogen receptor binding regulation of actin filament polymerization positive regulation of peptidyl-serine phosphorylation regulation of intracellular estrogen receptor signaling pathway cellular protein localization hippo signaling intracellular signal transduction positive regulation of apoptotic process regulation of protein complex assembly negative regulation of cyclin-dependent protein serine/threonine kinase activity regulation of organ growth metal ion binding cytoplasmic sequestering of protein cell division mammary gland epithelial cell differentiation negative regulation of canonical Wnt signaling pathway regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc007eig.1 uc007eig.2 uc007eig.3 uc007eig.4 
ENSMUST00000165961.2 Vmn1r129 ENSMUST00000165961.2 vomeronasal 1 receptor 129 (from RefSeq NM_001166725.1) E9QA94 E9QA94_MOUSE ENSMUST00000165961.1 NM_001166725 Vmn1r129 uc012fdd.1 uc012fdd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fdd.1 uc012fdd.2 
ENSMUST00000165963.9 Insyn2b ENSMUST00000165963.9 inhibitory synaptic factor family member 2B (from RefSeq NM_001025382.2) ENSMUST00000165963.1 ENSMUST00000165963.2 ENSMUST00000165963.3 ENSMUST00000165963.4 ENSMUST00000165963.5 ENSMUST00000165963.6 ENSMUST00000165963.7 ENSMUST00000165963.8 Fam196b INY2B_MOUSE NM_001025382 Q6GQV1 uc011xsz.1 uc011xsz.2 uc011xsz.3 Belongs to the INSYN2 family. molecular_function cellular_component biological_process uc011xsz.1 uc011xsz.2 uc011xsz.3 
ENSMUST00000165965.8 Mark2 ENSMUST00000165965.8 MAP/microtubule affinity regulating kinase 2, transcript variant 1 (from RefSeq NM_007928.4) E9PWB5 E9QMP6 E9QMP6_MOUSE ENSMUST00000165965.1 ENSMUST00000165965.2 ENSMUST00000165965.3 ENSMUST00000165965.4 ENSMUST00000165965.5 ENSMUST00000165965.6 ENSMUST00000165965.7 Mark2 NM_007928 uc008gkr.1 uc008gkr.2 uc008gkr.3 uc008gkr.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cell projection, dendrite Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleoplasm cytoplasm actin filament plasma membrane protein phosphorylation positive regulation of neuron projection development membrane kinase activity phosphorylation lateral plasma membrane transferase activity peptidyl-serine phosphorylation establishment of cell polarity dendrite intracellular signal transduction establishment or maintenance of epithelial cell apical/basal polarity tau-protein kinase activity regulation of axonogenesis regulation of microtubule cytoskeleton organization microtubule bundle uc008gkr.1 uc008gkr.2 uc008gkr.3 uc008gkr.4 
ENSMUST00000165971.3 Septin10 ENSMUST00000165971.3 septin 10, transcript variant 4 (from RefSeq NM_001379064.1) A0A0R4J233 A0A0R4J233_MOUSE ENSMUST00000165971.1 ENSMUST00000165971.2 NM_001379064 Sept10 Septin10 uc007fdn.1 uc007fdn.2 uc007fdn.3 uc007fdn.4 Filament-forming cytoskeletal GTPase. Septins polymerize into heterooligomeric protein complexes that form filaments. Cytoplasm Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. nucleotide binding GTP binding uc007fdn.1 uc007fdn.2 uc007fdn.3 uc007fdn.4 
ENSMUST00000165978.3 Tecpr2 ENSMUST00000165978.3 tectonin beta-propeller repeat containing 2, transcript variant 2 (from RefSeq NM_001289510.1) ENSMUST00000165978.1 ENSMUST00000165978.2 NM_001289510 Q3UH45 Q3UH45_MOUSE Tecpr2 uc007pch.1 uc007pch.2 uc007pch.3 uc007pch.4 uc007pch.5 molecular_function cellular_component biological_process uc007pch.1 uc007pch.2 uc007pch.3 uc007pch.4 uc007pch.5 
ENSMUST00000165988.2 Gm8122 ENSMUST00000165988.2 Gm8122 (from geneSymbol) ENSMUST00000165988.1 Gm8122 L7N2C7 L7N2C7_MOUSE uc288srh.1 uc288srh.2 molecular_function cellular_component biological_process uc288srh.1 uc288srh.2 
ENSMUST00000165990.8 Slco1a4 ENSMUST00000165990.8 solute carrier organic anion transporter family, member 1a4, transcript variant 1 (from RefSeq NM_030687.3) ENSMUST00000165990.1 ENSMUST00000165990.2 ENSMUST00000165990.3 ENSMUST00000165990.4 ENSMUST00000165990.5 ENSMUST00000165990.6 ENSMUST00000165990.7 NM_030687 Oatp1a4 Oatp2 Q9EP96 SO1A4_MOUSE Slc21a5 uc009eos.1 uc009eos.2 Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, prostaglandin E2, estrone 3-sulfate, L-thyroxine (T4), the cardiac glycosides ouabain and digoxin and thyroid hormones. Shows a pH- sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions. Reaction=estrone 3-sulfate(out) = estrone 3-sulfate(in); Xref=Rhea:RHEA:71835, ChEBI:CHEBI:60050; Evidence=; Reaction=taurocholate(out) = taurocholate(in); Xref=Rhea:RHEA:71703, ChEBI:CHEBI:36257; Evidence=; Reaction=prostaglandin E2(out) = prostaglandin E2(in); Xref=Rhea:RHEA:50984, ChEBI:CHEBI:606564; Evidence=; Reaction=L-thyroxine(out) = L-thyroxine(in); Xref=Rhea:RHEA:71819, ChEBI:CHEBI:58448; Evidence=; Cell membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=1; Comment=3 isoforms are produced.; Name=1; IsoId=Q9EP96-1; Sequence=Displayed; Highly expressed in brain and liver. Detected at very low levels in heart and lung. A conserved histidine residue in the third TMD (His-107) may play an essential role in the pH sensitivity of SLCO1A4/OATP1A4- mediated substrate transport. Belongs to the organo anion transporter (TC 2.A.60) family. plasma membrane integral component of plasma membrane ion transport anion transport organic anion transmembrane transporter activity bile acid transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity bile acid and bile salt transport membrane integral component of membrane sodium-independent organic anion transport transmembrane transport uc009eos.1 uc009eos.2 
ENSMUST00000166021.8 Gpatch4 ENSMUST00000166021.8 G patch domain containing 4, transcript variant 1 (from RefSeq NM_025663.4) ENSMUST00000166021.1 ENSMUST00000166021.2 ENSMUST00000166021.3 ENSMUST00000166021.4 ENSMUST00000166021.5 ENSMUST00000166021.6 ENSMUST00000166021.7 GPTC4_MOUSE Gpatc4 NM_025663 Q3TFK5 Q8VCN2 Q9CU32 Q9D3L4 uc012crm.1 uc012crm.2 uc012crm.3 uc012crm.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TFK5-1; Sequence=Displayed; Name=2; IsoId=Q3TFK5-2; Sequence=VSP_025482; Sequence=BAB30685.1; Type=Frameshift; Evidence=; hematopoietic progenitor cell differentiation nucleic acid binding cellular_component uc012crm.1 uc012crm.2 uc012crm.3 uc012crm.4 
ENSMUST00000166025.8 Gm3269 ENSMUST00000166025.8 Gm3269 (from geneSymbol) ENSMUST00000166025.1 ENSMUST00000166025.2 ENSMUST00000166025.3 ENSMUST00000166025.4 ENSMUST00000166025.5 ENSMUST00000166025.6 ENSMUST00000166025.7 Gm3269 K7N735 K7N735_MOUSE uc288qkt.1 uc288qkt.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qkt.1 uc288qkt.2 
ENSMUST00000166032.8 Tdrkh ENSMUST00000166032.8 tudor and KH domain containing protein, transcript variant 1 (from RefSeq NM_028307.2) ENSMUST00000166032.1 ENSMUST00000166032.2 ENSMUST00000166032.3 ENSMUST00000166032.4 ENSMUST00000166032.5 ENSMUST00000166032.6 ENSMUST00000166032.7 NM_028307 Q80VL1 TDRKH_MOUSE Tdrd2 uc008qge.1 uc008qge.2 uc008qge.3 Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules. Interacts with (symmetrically methylated) PIWIL1, PIWIL2 and PIWIL4. Cytoplasm. Mitochondrion. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Colocalizes with pi- and piP-bodies, a subset of the nuage which contains secondary piRNAs. Associated with mitochondria in the germline. Highly expressed in testis, present at lower level in brain. Weakly or not expressed in other tissues (at protein level). Present at low level in male gonads in postnatal day 7 (P7) Expressed at higher level in P14, P21 and adult testes, correlating with the onset of meiosis (at protein level). Expressed in spermatogonia, spermatocytes and round spermatids, but not in elongating spermatids. Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. Male mice are sterile due to defects in male meiosis, piRNA production defects, DNA demethylation of LINE-1 (L1) transposable elements and an increase in L1 expression in the adult testis. Mutants have severely reduced levels of mature piRNAs and accumulate 1'U-containing, 2'O-methylated 31-37 nt RNAs that complement the missing mature piRNAs. Belongs to the Tdrkh family. nucleic acid binding RNA binding protein binding cytoplasm mitochondrion cytosol male meiosis spermatogenesis fertilization cell differentiation gene silencing by RNA piRNA metabolic process DNA methylation involved in gamete generation pi-body piP-body uc008qge.1 uc008qge.2 uc008qge.3 
ENSMUST00000166040.9 Ppt2 ENSMUST00000166040.9 palmitoyl-protein thioesterase 2, transcript variant 3 (from RefSeq NM_001302394.1) ENSMUST00000166040.1 ENSMUST00000166040.2 ENSMUST00000166040.3 ENSMUST00000166040.4 ENSMUST00000166040.5 ENSMUST00000166040.6 ENSMUST00000166040.7 ENSMUST00000166040.8 NM_001302394 O35448 PPT2_MOUSE Q80WP5 uc056zep.1 uc056zep.2 uc056zep.3 Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity). Lysosome Expressed throughout the brain, primarily in neurons, and at lower levels in glial cells. Mice are healthy at birth, but develop neuronal abnormalities, infiltration of bone marrow by macrophages and multinucleated giant cells, and splenomegaly caused by extramedullary hematopoiesis. Autofluorescent storage material is present in many cell types, particularly reticuloendothelial cells and neurons. Belongs to the palmitoyl-protein thioesterase family. lysosome palmitoyl-(protein) hydrolase activity hydrolase activity thiolester hydrolase activity palmitoyl hydrolase activity macromolecule depalmitoylation uc056zep.1 uc056zep.2 uc056zep.3 
ENSMUST00000166047.2 Gm17122 ENSMUST00000166047.2 Gm17122 (from geneSymbol) ENSMUST00000166047.1 uc290ymr.1 uc290ymr.2 uc290ymr.1 uc290ymr.2 
ENSMUST00000166056.9 Omt2a ENSMUST00000166056.9 oocyte maturation, alpha, transcript variant 1 (from RefSeq NM_001111286.2) ENSMUST00000166056.1 ENSMUST00000166056.2 ENSMUST00000166056.3 ENSMUST00000166056.4 ENSMUST00000166056.5 ENSMUST00000166056.6 ENSMUST00000166056.7 ENSMUST00000166056.8 G5E8X8 G5E8X8_MOUSE NM_001111286 Omt2a uc012gxc.1 uc012gxc.2 uc012gxc.3 molecular_function cytosol biological_process membrane integral component of membrane uc012gxc.1 uc012gxc.2 uc012gxc.3 
ENSMUST00000166079.2 Vmn1r151 ENSMUST00000166079.2 vomeronasal 1 receptor 151 (from RefSeq NM_001166712.1) ENSMUST00000166079.1 L7N288 L7N288_MOUSE NM_001166712 Vmn1r151 uc012feb.1 uc012feb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane pheromone receptor activity response to pheromone uc012feb.1 uc012feb.2 
ENSMUST00000166080.2 Gm28041 ENSMUST00000166080.2 Gm28041 (from geneSymbol) BC065418 ENSMUST00000166080.1 F2Z406 F2Z406_MOUSE Gm28041 Zfp456 uc288oel.1 uc288oel.2 nucleic acid binding cellular_component regulation of transcription, DNA-templated uc288oel.1 uc288oel.2 
ENSMUST00000166081.3 Vmn2r100 ENSMUST00000166081.3 vomeronasal 2, receptor 100 (from RefSeq NM_001104562.1) E9QAZ9 E9QAZ9_MOUSE ENSMUST00000166081.1 ENSMUST00000166081.2 NM_001104562 Vmn2r100 uc009vbe.1 uc009vbe.2 uc009vbe.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vbe.1 uc009vbe.2 uc009vbe.3 
ENSMUST00000166086.3 Speer4f2 ENSMUST00000166086.3 spermatogenesis associated glutamate (E)-rich protein 4f2 (from RefSeq NM_001374718.1) E9Q366 E9Q366_MOUSE ENSMUST00000166086.1 ENSMUST00000166086.2 Gm3495 NM_001374718 Speer4f2 uc290tht.1 uc290tht.2 molecular_function cellular_component biological_process uc290tht.1 uc290tht.2 
ENSMUST00000166099.3 Sap25 ENSMUST00000166099.3 sin3 associated polypeptide (from RefSeq NM_001081962.2) E9Q529 E9Q529_MOUSE ENSMUST00000166099.1 ENSMUST00000166099.2 NM_001081962 Sap25 uc291ayf.1 uc291ayf.2 nucleus cytoplasm regulation of transcription, DNA-templated uc291ayf.1 uc291ayf.2 
ENSMUST00000166100.2 Serpinb3b ENSMUST00000166100.2 Belongs to the serpin family. Ov-serpin subfamily. (from UniProt Q9D1Q5) AK003220 ENSMUST00000166100.1 Q9D1Q5 Q9D1Q5_MOUSE Serpinb3b uc287kxw.1 uc287kxw.2 Belongs to the serpin family. Ov-serpin subfamily. serine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular space negative regulation of endopeptidase activity uc287kxw.1 uc287kxw.2 
ENSMUST00000166117.4 Gen1 ENSMUST00000166117.4 GEN1, Holliday junction 5' flap endonuclease (from RefSeq NM_177331.5) B2RR04 ENSMUST00000166117.1 ENSMUST00000166117.2 ENSMUST00000166117.3 GEN_MOUSE NM_177331 Q3TYY2 Q5CZW6 Q8BMI4 Q8C0J0 uc007nav.1 uc007nav.2 uc007nav.3 Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction. Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA. Has also endonuclease activity on 5'-flap and replication fork (RF) DNA substrates. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding. ; Largely monomeric, dimerizes on the Holliday junction and the first nick occurs upon dimerization at the junction. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BMI4-1; Sequence=Displayed; Name=2; IsoId=Q8BMI4-2; Sequence=VSP_030216; Expressed in bone marrow and testis and to a lesser extent in thymus, spleen, brain and colon. XPG-N, XPG-I,5'-3' exonuclease domains interact with DNA. Contains a chromodomain that acts as additional DNA interaction site and is required for efficient DNA recognition and cleavage. Belongs to the XPG/RAD2 endonuclease family. GEN subfamily. magnesium ion binding four-way junction DNA binding double-strand break repair via homologous recombination DNA binding catalytic activity nuclease activity endonuclease activity nucleus centrosome DNA repair cellular response to DNA damage stimulus crossover junction endodeoxyribonuclease activity regulation of centrosome duplication hydrolase activity 5'-flap endonuclease activity replication fork processing protein homodimerization activity metal ion binding flap endonuclease activity resolution of recombination intermediates resolution of mitotic recombination intermediates positive regulation of mitotic cell cycle spindle assembly checkpoint nucleic acid phosphodiester bond hydrolysis uc007nav.1 uc007nav.2 uc007nav.3 
ENSMUST00000166121.4 Phf11b ENSMUST00000166121.4 PHD finger protein 11B (from RefSeq NM_001164327.1) B4XVQ1 B4XVQ1_MOUSE EG628705 ENSMUST00000166121.1 ENSMUST00000166121.2 ENSMUST00000166121.3 Gm4902 NM_001164327 Phf11-3 Phf11b uc011zml.1 uc011zml.2 uc011zml.3 Nucleus molecular_function nucleoplasm biological_process nuclear membrane metal ion binding uc011zml.1 uc011zml.2 uc011zml.3 
ENSMUST00000166123.9 Eif5 ENSMUST00000166123.9 eukaryotic translation initiation factor 5, transcript variant 2 (from RefSeq NM_178041.2) ENSMUST00000166123.1 ENSMUST00000166123.2 ENSMUST00000166123.3 ENSMUST00000166123.4 ENSMUST00000166123.5 ENSMUST00000166123.6 ENSMUST00000166123.7 ENSMUST00000166123.8 Eif5 NM_178041 Q3TQR3 Q3TQR3_MOUSE uc007pde.1 uc007pde.2 uc007pde.3 uc007pde.4 Belongs to the eIF-2-beta/eIF-5 family. formation of translation preinitiation complex translation initiation factor activity cytoplasm cytosol plasma membrane translational initiation regulation of translational initiation eukaryotic initiation factor eIF2 binding activation of GTPase activity uc007pde.1 uc007pde.2 uc007pde.3 uc007pde.4 
ENSMUST00000166131.2 Vmn2r61 ENSMUST00000166131.2 vomeronasal 2, receptor 61 (from RefSeq NM_001105058.1) ENSMUST00000166131.1 L7N2B8 L7N2B8_MOUSE NM_001105058 Vmn2r61 uc012fix.1 uc012fix.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012fix.1 uc012fix.2 
ENSMUST00000166139.7 Vash2 ENSMUST00000166139.7 vasohibin 2, transcript variant 2 (from RefSeq NR_027352.1) ENSMUST00000166139.1 ENSMUST00000166139.2 ENSMUST00000166139.3 ENSMUST00000166139.4 ENSMUST00000166139.5 ENSMUST00000166139.6 NR_027352 Q3TR02 Q8BRA1 Q8C5G2 Q8R1R8 VASH2_MOUSE Vash2 Vashl uc007ebs.1 uc007ebs.2 uc007ebs.3 Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146868). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911). Reaction=C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl- [tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl- [tubulin] + L-tyrosine; Xref=Rhea:RHEA:57444, Rhea:RHEA-COMP:16434, Rhea:RHEA-COMP:16435, ChEBI:CHEBI:15377, ChEBI:CHEBI:58315, ChEBI:CHEBI:149554, ChEBI:CHEBI:149555; EC=3.4.17.17; Evidence=; Interacts with SVBP; interaction enhances VASH2 tyrosine carboxypeptidase activity. Cytoplasm Secreted Cytoplasm, cytoskeleton Note=Mainly localizes in the cytoplasm. Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion. Associates with microtubules (By similarity). Preferentially expressed in bone marrow-derived mononuclear cells at the sprouting front. Belongs to the transglutaminase-like superfamily. Vasohibin family. Sequence=AAH24141.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; syncytium formation by plasma membrane fusion positive regulation of endothelial cell proliferation actin binding carboxypeptidase activity metallocarboxypeptidase activity protein binding extracellular region cytoplasm proteolysis peptidase activity hydrolase activity regulation of angiogenesis positive regulation of angiogenesis placenta blood vessel development labyrinthine layer development labyrinthine layer blood vessel development uc007ebs.1 uc007ebs.2 uc007ebs.3 
ENSMUST00000166140.8 Tldc2 ENSMUST00000166140.8 TBC/LysM associated domain containing 2 (from RefSeq NM_001177439.2) E9PZS3 E9PZS3_MOUSE ENSMUST00000166140.1 ENSMUST00000166140.2 ENSMUST00000166140.3 ENSMUST00000166140.4 ENSMUST00000166140.5 ENSMUST00000166140.6 ENSMUST00000166140.7 Gm1332 NM_001177439 Tldc2 uc012chx.1 uc012chx.2 uc012chx.1 uc012chx.2 
ENSMUST00000166142.11 Kctd17 ENSMUST00000166142.11 potassium channel tetramerisation domain containing 17, transcript variant 2 (from RefSeq NM_001289672.2) A6H697 A6H697_MOUSE ENSMUST00000166142.1 ENSMUST00000166142.10 ENSMUST00000166142.2 ENSMUST00000166142.3 ENSMUST00000166142.4 ENSMUST00000166142.5 ENSMUST00000166142.6 ENSMUST00000166142.7 ENSMUST00000166142.8 ENSMUST00000166142.9 F6SYN4 Kctd17 NM_001289672 uc007wph.1 uc007wph.2 uc007wph.3 uc007wph.4 cytoplasm endoplasmic reticulum Cul3-RING ubiquitin ligase complex endoplasmic reticulum calcium ion homeostasis identical protein binding proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of cilium assembly protein homooligomerization cullin family protein binding uc007wph.1 uc007wph.2 uc007wph.3 uc007wph.4 
ENSMUST00000166163.4 Jakmip3 ENSMUST00000166163.4 janus kinase and microtubule interacting protein 3 (from RefSeq NM_028708.2) ENSMUST00000166163.1 ENSMUST00000166163.2 ENSMUST00000166163.3 JKIP3_MOUSE Kiaa4091 NM_028708 Necc2 Q0VDR4 Q0VDR5 Q5DTN8 Q9CU41 uc291wqc.1 uc291wqc.2 uc291wqc.3 Golgi apparatus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5DTN8-1; Sequence=Displayed; Name=2; IsoId=Q5DTN8-2; Sequence=VSP_032000, VSP_032002, VSP_032003; Name=3; IsoId=Q5DTN8-3; Sequence=VSP_032001, VSP_032002, VSP_032003; [Isoform 2]: Due to intron retention. [Isoform 3]: Due to intron retention. Belongs to the JAKMIP family. Sequence=BAD90506.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component Golgi apparatus microtubule binding biological_process kinase binding uc291wqc.1 uc291wqc.2 uc291wqc.3 
ENSMUST00000166170.9 Nell2 ENSMUST00000166170.9 NEL-like 2, transcript variant 2 (from RefSeq NM_001356951.1) ENSMUST00000166170.1 ENSMUST00000166170.2 ENSMUST00000166170.3 ENSMUST00000166170.4 ENSMUST00000166170.5 ENSMUST00000166170.6 ENSMUST00000166170.7 ENSMUST00000166170.8 Mel91 NELL2_MOUSE NM_001356951 Nell2 Q61220 Q80UM5 uc289avp.1 uc289avp.2 Plays multiple roles in neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions. Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway (By similarity) (PubMed:32198364, PubMed:26586761). Via binding to its receptor ROBO3, plays a role in axon guidance, functioning as a repulsive axon guidance cue that contributes to commissural axon guidance to the midline (PubMed:32198364, PubMed:26586761). Required for neuron survival through the modulation of MAPK signaling pathways too. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity). Epididymal-secreted protein that signals through a ROS1- pathway to regulate the epididymal initial segment (IS) maturation, sperm maturation and male fertility. Homotrimer (PubMed:32198364). Interacts with NICOL1; this interaction triggers epididymal differentiation (PubMed:37095084). Interacts (via EGF domains) with ROBO3 (via FN domains); binding to ROBO3 induces repulsive guidance cue for commissural axons (PubMed:26586761, PubMed:32198364). Secreted Note=Detected in the epididymal lumen. Expressed in brain and testis but not in epididymis (PubMed:32499443). Expressed in regions flanking the commissural axon trajectory, including the ventral horn (PubMed:26586761). At 9.5 dpc expressed in the presumptive motor column in the ventral horn. At 10.5 dpc, additional sites of expression include dorsal root ganglia, the dorsal mantle layer of the spinal cord, and a triangular population of cells close to the ventricle. Expression in cells forming ventral corridor persists at 11.5 dpc. Deficient male mice exhibit infertility, impaired binding of sperm to zona pellucida, and impaired sperm migration in female genital tract. Postnatal differentiation of the initial segment (IS) of the caput epididymis is completely abolished in Nell2 deficient males and continued throughout life. Ovch2 is not secreted and Adam3 is not processed into its mature form in cauda epididymal spermatozoa, leading to inability of spermatozoa to pass through the uterotubal junction and to bind to the zona pellucida. It is uncertain whether Met-1 or Met-4 is the initiator. protein kinase C binding calcium ion binding extracellular region extracellular space cytoplasm heparin binding membrane dendrite regulation of growth identical protein binding perikaryon development of secondary female sexual characteristics positive regulation of hormone secretion neuron cellular homeostasis protein homotrimerization uc289avp.1 uc289avp.2 
ENSMUST00000166173.3 S100a7l2 ENSMUST00000166173.3 S100 calcium binding protein A7 like 2 (from RefSeq NM_001101461.2) 9130204L05Rik ENSMUST00000166173.1 ENSMUST00000166173.2 G3UWB8 G3UWB8_MOUSE NM_001101461 S100a7l2 uc008qdh.1 uc008qdh.2 uc008qdh.3 molecular_function cellular_component biological_process uc008qdh.1 uc008qdh.2 uc008qdh.3 
ENSMUST00000166176.9 Mocs2 ENSMUST00000166176.9 molybdenum cofactor synthesis 2, transcript variant 6 (from RefSeq NM_001426248.1) A0A0R4J206 A0A0R4J206_MOUSE ENSMUST00000166176.1 ENSMUST00000166176.2 ENSMUST00000166176.3 ENSMUST00000166176.4 ENSMUST00000166176.5 ENSMUST00000166176.6 ENSMUST00000166176.7 ENSMUST00000166176.8 MOCS2 Mocs2 NM_001426248 uc007rxv.1 uc007rxv.2 uc007rxv.3 uc007rxv.4 Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. Reaction=2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin; Xref=Rhea:RHEA:26333, Rhea:RHEA-COMP:12160, Rhea:RHEA-COMP:12202, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58698, ChEBI:CHEBI:59648, ChEBI:CHEBI:90619, ChEBI:CHEBI:90778; EC=2.8.1.12; Evidence= Cofactor biosynthesis; molybdopterin biosynthesis. Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits. Cytoplasm, cytosol This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame. Belongs to the MoaE family. MOCS2B subfamily. nucleus cytoplasm cytosol Mo-molybdopterin cofactor biosynthetic process nuclear speck transferase activity molybdopterin synthase complex molybdopterin synthase activity uc007rxv.1 uc007rxv.2 uc007rxv.3 uc007rxv.4 
ENSMUST00000166179.9 Mb ENSMUST00000166179.9 myoglobin, transcript variant 2 (from RefSeq NM_013593.3) ENSMUST00000166179.1 ENSMUST00000166179.2 ENSMUST00000166179.3 ENSMUST00000166179.4 ENSMUST00000166179.5 ENSMUST00000166179.6 ENSMUST00000166179.7 ENSMUST00000166179.8 Glng Mb NM_013593 Q3UVB1 Q3UVB1_MOUSE uc007wmy.1 uc007wmy.2 uc007wmy.3 Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Belongs to the globin family. oxygen transporter activity response to hormone oxygen transport oxygen binding heme binding slow-twitch skeletal muscle fiber contraction response to hydrogen peroxide metal ion binding uc007wmy.1 uc007wmy.2 uc007wmy.3 
ENSMUST00000166193.9 Igfn1 ENSMUST00000166193.9 immunoglobulin-like and fibronectin type III domain containing 1 (from RefSeq NM_177642.3) ENSMUST00000166193.1 ENSMUST00000166193.2 ENSMUST00000166193.3 ENSMUST00000166193.4 ENSMUST00000166193.5 ENSMUST00000166193.6 ENSMUST00000166193.7 ENSMUST00000166193.8 IGFN1_MOUSE NM_177642 Q3KNY0 Q8BZ74 uc011wst.1 uc011wst.2 uc011wst.3 Interacts with FLNC. Interacts with KY. Nucleus Cytoplasm, myofibril, sarcomere, Z line Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=IGFN1; IsoId=Q3KNY0-1; Sequence=Displayed; Name=2; Synonyms=IGFN1_v2; IsoId=Q3KNY0-2; Sequence=VSP_039842; Name=3; Synonyms=IGFN1_v3; IsoId=Q3KNY0-3; Sequence=VSP_035062, VSP_035065; Name=4; Synonyms=IGFN1_v1; IsoId=Q3KNY0-4; Sequence=VSP_039843; Name=5; IsoId=Q3KNY0-5; Sequence=VSP_035061; Isoform 1, isoform 3 and isoform 4 are expressed in skeletal muscle while isoform 2 is detected in both skeletal muscle and heart (at protein level). Sequence=AAI07028.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI07029.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleus cytoplasm biological_process sarcomere Z disc uc011wst.1 uc011wst.2 uc011wst.3 
ENSMUST00000166206.9 Smok3b ENSMUST00000166206.9 May play a role in sperm motility, especially in the regulation of flagellar function. (from UniProt C0HKC9) AK133180 C0HKC9 ENSMUST00000166206.1 ENSMUST00000166206.2 ENSMUST00000166206.3 ENSMUST00000166206.4 ENSMUST00000166206.5 ENSMUST00000166206.6 ENSMUST00000166206.7 ENSMUST00000166206.8 Q9QYZ5 SMK3B_MOUSE Smok3b uc033inf.1 uc033inf.2 uc033inf.3 May play a role in sperm motility, especially in the regulation of flagellar function. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Testis-specific. Expressed in the testis from 22 days postpartum (22 dpp). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity intracellular signal transduction uc033inf.1 uc033inf.2 uc033inf.3 
ENSMUST00000166219.2 Hsbp1l1 ENSMUST00000166219.2 heat shock factor binding protein 1-like 1 (from RefSeq NM_001136181.1) B2RXB2 ENSMUST00000166219.1 HSBPL_MOUSE NM_001136181 uc008fss.1 uc008fss.2 uc008fss.3 uc008fss.4 uc008fss.5 Belongs to the HSBP1 family. molecular_function transcription corepressor activity nucleus cytoplasm cytosol cellular heat acclimation negative regulation of nucleic acid-templated transcription uc008fss.1 uc008fss.2 uc008fss.3 uc008fss.4 uc008fss.5 
ENSMUST00000166232.4 Bcar1 ENSMUST00000166232.4 breast cancer anti-estrogen resistance 1, transcript variant 2 (from RefSeq NM_009954.3) BCAR1_MOUSE Cas Crkas ENSMUST00000166232.1 ENSMUST00000166232.2 ENSMUST00000166232.3 NM_009954 Q60869 Q61140 Q6PFF9 uc009nmu.1 uc009nmu.2 uc009nmu.3 uc009nmu.4 uc009nmu.5 Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (By similarity). Implicated in induction of cell migration and cell branching (PubMed:25499443). Involved in the BCAR3-mediated inhibition of TGFB signaling (PubMed:25499443). Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase. Can heterodimerize with NEDD9. Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (By similarity). Within the complex, interacts with SH2D3C (via C-terminus), and CRK (By similarity). Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain) and SRC; the formation of the complex is dependent on intergrin mediated-tyrosine phosphorylation of PTPRA (PubMed:22801373). Interacts with BCAR3 (via Ras-GEF domain); the interaction regulates adhesion-dependent serine phosphorylation (PubMed:10896938, PubMed:22801373). Interacts with SMAD2 and SMAD3 (PubMed:25499443). Interacts with NPHP1 (PubMed:10739664). Interacts with PTK2B/PYK2 (By similarity). Interacts (via C-terminus) with SH2D3C/CHAT isoform 2 (via C-terminus) (PubMed:10692442, PubMed:12486027, PubMed:17174122). Interacts with activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1 (By similarity). Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas (By similarity). Interacts with TNK2 via SH3 domains. Interacts (when tyrosine-phosphorylated) with tensin TNS1; the interaction is increased by phosphorylation of TNS1 (By similarity). Q61140; Q9QY53: Nphp1; NbExp=2; IntAct=EBI-77088, EBI-77230; Q61140; P34152: Ptk2; NbExp=3; IntAct=EBI-77088, EBI-77070; Q61140; Q9QWI6: Srcin1; NbExp=2; IntAct=EBI-77088, EBI-775592; Q61140; P18031: PTPN1; Xeno; NbExp=5; IntAct=EBI-77088, EBI-968788; Cell junction, focal adhesion Cytoplasm Cell projection, axon Note=Unphosphorylated form localizes in the cytoplasm (PubMed:22801373). Localizes to focal adhesion sites following integrin engagement (PubMed:22801373). Event=Alternative splicing; Named isoforms=2; Name=Cas-B; IsoId=Q61140-1; Sequence=Displayed; Name=Cas-A; IsoId=Q61140-2; Sequence=VSP_004134; Expressed in olfactory sensory neurons (at protein level) (PubMed:20881139). Expressed abundantly in the liver, lung, brain, and at lower levels in the heart (at protein level) (PubMed:19365570). Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9. A serine-rich region promotes activation of the serum response element (SRE). The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK1. PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC- family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix (By similarity). Dephosphorylated by PTPN14 at Tyr-132. Phosphorylated by SRC kinase in a EDN1- and PTK2B-mediated manner; phosphorylation strengthens its interaction with BCAR3 as part of the PTK2B/BCAR1/BCAR3/RAP1 signaling pathway. Belongs to the CAS family. ruffle protein binding cytoplasm cytosol plasma membrane focal adhesion actin filament organization cell adhesion signal transduction epidermal growth factor receptor signaling pathway G-protein coupled receptor signaling pathway integrin-mediated signaling pathway insulin receptor signaling pathway positive regulation of endothelial cell migration actin cytoskeleton cell migration SH3 domain binding protein kinase binding protein domain specific binding lamellipodium actin cytoskeleton organization cell junction positive regulation of cell migration cellular response to hepatocyte growth factor stimulus platelet-derived growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway neurotrophin TRK receptor signaling pathway hepatocyte growth factor receptor signaling pathway antigen receptor-mediated signaling pathway B cell receptor signaling pathway cell chemotaxis cellular response to nitric oxide actin filament reorganization negative regulation of substrate adhesion-dependent cell spreading cellular response to endothelin uc009nmu.1 uc009nmu.2 uc009nmu.3 uc009nmu.4 uc009nmu.5 
ENSMUST00000166237.8 Sema4a ENSMUST00000166237.8 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A, transcript variant 2 (from RefSeq NM_001163489.1) D3Z5L2 ENSMUST00000166237.1 ENSMUST00000166237.2 ENSMUST00000166237.3 ENSMUST00000166237.4 ENSMUST00000166237.5 ENSMUST00000166237.6 ENSMUST00000166237.7 NM_001163489 Q62178 SEM4A_MOUSE SemB Semab uc008pvi.1 uc008pvi.2 uc008pvi.3 Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (PubMed:20043131, PubMed:17318185). Regulates glutamatergic and GABAergic synapse development (PubMed:29981480). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (PubMed:29981480). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (PubMed:15780988). Promotes phosphorylation of TIMD2 (PubMed:12374982). Inhibits angiogenesis (PubMed:17318185). Promotes axon growth cone collapse (PubMed:20043131). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (PubMed:20043131). Interacts with PLXNB1, PLXNB2 and PLXNB3 (PubMed:20043131). Interacts with PLXND1 (PubMed:17318185). Interacts with TIMD2 (PubMed:12374982). Cell membrane ingle-pass type I membrane protein Expressed in neurons and glia in the developing hippocampus. Expressed from day 10 in the embryo. Low levels found between days 10-12. Expression peaks on day 13 with moderate levels from then until birth. Results are contradictory; one study (PubMed:15780988) finds no visible phenotype; mice are born at the expected Mendelian ratio and are fertile, but they present defects in T-cell differentiation and in T-cell responses to antigens. According to another publication (PubMed:15277503) gene disruption leads to degeneration of photoreceptor cells in the retina within the first month of life. Belongs to the semaphorin family. angiogenesis neural crest cell migration adaptive immune response T cell differentiation involved in immune response immune system process extracellular space nucleus cytosol plasma membrane integral component of plasma membrane multicellular organism development nervous system development axonogenesis regulation of cell shape regulation of endothelial cell migration membrane integral component of membrane negative regulation of angiogenesis cell differentiation semaphorin receptor binding positive regulation of cell migration intracellular membrane-bounded organelle T-helper 1 cell differentiation chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway positive regulation of excitatory synapse assembly positive regulation of inhibitory synapse assembly uc008pvi.1 uc008pvi.2 uc008pvi.3 
ENSMUST00000166240.8 Lrriq1 ENSMUST00000166240.8 leucine-rich repeats and IQ motif containing 1, transcript variant 1 (from RefSeq NM_001163559.2) ENSMUST00000166240.1 ENSMUST00000166240.2 ENSMUST00000166240.3 ENSMUST00000166240.4 ENSMUST00000166240.5 ENSMUST00000166240.6 ENSMUST00000166240.7 LRIQ1_MOUSE NM_001163559 Q0P5X1 Q3TYL6 Q9CUK8 uc011xmu.1 uc011xmu.2 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0P5X1-1; Sequence=Displayed; Name=2; IsoId=Q0P5X1-2; Sequence=VSP_040541, VSP_040542; Sequence=BAE34547.1; Type=Frameshift; Evidence=; cytoplasm biological_process protein kinase binding uc011xmu.1 uc011xmu.2 
ENSMUST00000166241.2 Slitrk2 ENSMUST00000166241.2 SLIT and NTRK-like family, member 2, transcript variant 1 (from RefSeq NM_001161431.1) ENSMUST00000166241.1 NM_001161431 Q810C0 Q8BXL6 SLIK2_MOUSE uc012hig.1 uc012hig.2 uc012hig.3 It is involved in synaptogenesis (PubMed:25989451, PubMed:35840571). Promotes excitatory synapse differentiation (By similarity). Suppresses neurite outgrowth (PubMed:14550773). Involved in the negative regulation of NTRK2 (PubMed:35840571). Interacts with PTPRD; this interaction is PTPRD splicing- dependent and may induce pre-synaptic differentiation. Interacts with NTRK2 (By similarity). Membrane ; Single-pass type I membrane protein Cell membrane Cell projection, dendrite In the adult, significant expression is detected only in the brain. Broadly expressed in embryonic brain with highest expression in ventricular layer, subventricular zone, cortical plate, pyramidal layer of hippocampus, subicular neuroepithelium, thalamus, hypothalamus and spinal cord. In the embryo, expressed from day 9-12 and continues through later gestational development and into adulthood. Conditional knockout of the gene causes impaired long-term memory and abnormal gait. Excitatory neuronal development is abnormal in the mutant animals as evidenced by a reduction of excitatory synaptic puncta in the hippocampus. Hippocampal CA1 pyramidal cell-targeted knockout of the gene results in impaired synapse maintenance and abnormal retention of spatial reference memory. Belongs to the SLITRK family. protein binding plasma membrane axonogenesis membrane integral component of membrane regulation of synapse organization positive regulation of synapse assembly glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane synaptic membrane adhesion regulation of presynapse assembly uc012hig.1 uc012hig.2 uc012hig.3 
ENSMUST00000166247.8 Tmem176b ENSMUST00000166247.8 transmembrane protein 176B, transcript variant 4 (from RefSeq NM_001164208.1) Clast1 ENSMUST00000166247.1 ENSMUST00000166247.2 ENSMUST00000166247.3 ENSMUST00000166247.4 ENSMUST00000166247.5 ENSMUST00000166247.6 ENSMUST00000166247.7 Lr8 NM_001164208 Q9R1Q6 Q9WU52 T176B_MOUSE uc009bvv.1 uc009bvv.2 uc009bvv.3 uc009bvv.4 uc009bvv.5 May play a role in the process of maturation of dendritic cells (By similarity). Required for the development of cerebellar granule cells. Nucleus membrane ; Multi-pass membrane protein Ubiquitously expressed with higher expression in lung, liver, kidney and colon. Expressed in cerebellar granule cells. Expressed in the developing cerebellum at constant levels from 18 dpc to P7. Mice exhibit abnormal development of the cerebellum and severe ataxia. Belongs to the TMEM176 family. protein binding nucleus membrane integral component of membrane cell differentiation nuclear membrane negative regulation of dendritic cell differentiation uc009bvv.1 uc009bvv.2 uc009bvv.3 uc009bvv.4 uc009bvv.5 
ENSMUST00000166255.2 Gm54608 ENSMUST00000166255.2 Gm54608 (from geneSymbol) A0A075B676 A0A075B676_MOUSE ENSMUST00000166255.1 Gm54608 Ighv5-8 uc288jtq.1 uc288jtq.2 uc288jtq.1 uc288jtq.2 
ENSMUST00000166259.8 Neu2 ENSMUST00000166259.8 neuraminidase 2, transcript variant 2 (from RefSeq NM_001160164.2) ENSMUST00000166259.1 ENSMUST00000166259.2 ENSMUST00000166259.3 ENSMUST00000166259.4 ENSMUST00000166259.5 ENSMUST00000166259.6 ENSMUST00000166259.7 NEUR2_MOUSE NM_001160164 Q99NA3 Q9JMH3 uc011woq.1 uc011woq.2 uc011woq.3 uc011woq.4 Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (PubMed:10713120). Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate (By similarity). Displays preference for alpha- (2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)- sialylated GD1b, in both monomeric forms and micelles (PubMed:10713120). Hydrolyzes exclusively monomeric GM1 ganglioside, but has no activity toward the miscellar form (By similarity). Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)- sialyl linkages (By similarity). Cleaves milk oligosaccharide alpha- (2->3)-sialyllactose, but is inactive toward isomer alpha-(2->6)- sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues (By similarity). Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha- (2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.; EC=3.2.1.18; Evidence=; Reaction=a ganglioside GD1a + H2O = a ganglioside GM1 + N- acetylneuraminate; Xref=Rhea:RHEA:47832, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:82637, ChEBI:CHEBI:82639; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47833; Evidence=; Reaction=a ganglioside GM1 + H2O = a ganglioside GA1 + N- acetylneuraminate; Xref=Rhea:RHEA:47872, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:82639, ChEBI:CHEBI:88069; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47873; Evidence=; Reaction=a ganglioside GT1b + H2O = a ganglioside GD1b + N- acetylneuraminate; Xref=Rhea:RHEA:47828, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:82939, ChEBI:CHEBI:82940; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47829; Evidence=; Reaction=a ganglioside GD1b + H2O = a ganglioside GM1 + N- acetylneuraminate; Xref=Rhea:RHEA:47876, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:82639, ChEBI:CHEBI:82939; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47877; Evidence=; Reaction=a ganglioside GD3 + H2O = a ganglioside GM3 + N- acetylneuraminate; Xref=Rhea:RHEA:48120, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:79210, ChEBI:CHEBI:79214; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48121; Evidence=; Reaction=a ganglioside GM3 + H2O = a beta-D-galactosyl-(1->4)-beta-D- glucosyl-(1<->1)-ceramide + N-acetylneuraminate; Xref=Rhea:RHEA:48136, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:79208, ChEBI:CHEBI:79210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48137; Evidence=; Reaction=a ganglioside GM2 + H2O = a ganglioside GA2 + N- acetylneuraminate; Xref=Rhea:RHEA:48172, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:79218, ChEBI:CHEBI:90085; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48173; Evidence=; Reaction=a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:47852, ChEBI:CHEBI:15377, ChEBI:CHEBI:17006, ChEBI:CHEBI:35418, ChEBI:CHEBI:58665; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47853; Evidence=; Reaction=H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl- (1->4)-D-glucose = lactose + N-acetylneuraminate; Xref=Rhea:RHEA:64640, ChEBI:CHEBI:15377, ChEBI:CHEBI:17716, ChEBI:CHEBI:35418, ChEBI:CHEBI:156068; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64641; Evidence=; Cytoplasm, cytosol Highly expressed in heart. Belongs to the glycosyl hydrolase 33 family. Sequence=BAB39152.1; Type=Erroneous initiation; Evidence=; exo-alpha-sialidase activity cytoplasm lysosome cytosol carbohydrate metabolic process lipid metabolic process ganglioside catabolic process metabolic process oligosaccharide catabolic process positive regulation of myotube differentiation membrane lipid catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds intracellular membrane-bounded organelle positive regulation of myoblast differentiation cellular oligosaccharide catabolic process exo-alpha-(2->3)-sialidase activity exo-alpha-(2->6)-sialidase activity exo-alpha-(2->8)-sialidase activity catalytic complex uc011woq.1 uc011woq.2 uc011woq.3 uc011woq.4 
ENSMUST00000166278.7 Gpr160 ENSMUST00000166278.7 G protein-coupled receptor 160, transcript variant 3 (from RefSeq NM_001134386.2) ENSMUST00000166278.1 ENSMUST00000166278.2 ENSMUST00000166278.3 ENSMUST00000166278.4 ENSMUST00000166278.5 ENSMUST00000166278.6 GP160_MOUSE NM_001134386 Q3U3F9 Q9D9Y9 uc008ovj.1 uc008ovj.2 uc008ovj.3 uc008ovj.4 uc008ovj.5 Orphan receptor. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. Sequence=BAB24531.1; Type=Frameshift; Evidence=; G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane receptor complex uc008ovj.1 uc008ovj.2 uc008ovj.3 uc008ovj.4 uc008ovj.5 
ENSMUST00000166280.8 Dlk2 ENSMUST00000166280.8 delta like non-canonical Notch ligand 2, transcript variant 5 (from RefSeq NM_001414443.1) B5B9L4 DLK2_MOUSE ENSMUST00000166280.1 ENSMUST00000166280.2 ENSMUST00000166280.3 ENSMUST00000166280.4 ENSMUST00000166280.5 ENSMUST00000166280.6 ENSMUST00000166280.7 Egfl9 NM_001414443 Q0IIP7 Q148N7 Q8K1E3 Q9QYP3 uc008csl.1 uc008csl.2 uc008csl.3 uc008csl.4 Regulates adipogenesis. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=Q8K1E3-1; Sequence=Displayed; Name=1; IsoId=Q8K1E3-3; Sequence=VSP_039583; Name=3; IsoId=Q8K1E3-4; Sequence=VSP_039584; Detected in a number of tissues including lung, brain, adrenal gland, testis, adult liver, placenta, ovary and thymus. Not detected in fetal liver or in adult spleen, muscle and heart. Absent from liver after birth, but increases around postnatal day 16. [Isoform 3]: Splice sites are non-canonical. Sequence=BAA88686.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Notch binding calcium ion binding plasma membrane Notch signaling pathway membrane integral component of membrane protein homodimerization activity regulation of fat cell differentiation negative regulation of Notch signaling pathway uc008csl.1 uc008csl.2 uc008csl.3 uc008csl.4 
ENSMUST00000166281.3 Prlh ENSMUST00000166281.3 prolactin releasing hormone (from RefSeq NM_001101647.2) ENSMUST00000166281.1 ENSMUST00000166281.2 G3UWC3 G3UWC3_MOUSE NM_001101647 Prlh uc011wpd.1 uc011wpd.2 uc011wpd.3 tissue homeostasis response to dietary excess reduction of food intake in response to dietary excess hormone activity neuropeptide hormone activity cytoplasm energy reserve metabolic process lipid metabolic process G-protein coupled receptor signaling pathway feeding behavior response to glucose prolactin-releasing peptide receptor binding response to insulin regulation of multicellular organism growth eating behavior response to peptide hormone fat cell differentiation autonomic nervous system development uc011wpd.1 uc011wpd.2 uc011wpd.3 
ENSMUST00000166290.2 Has2os ENSMUST00000166290.2 Has2os (from geneSymbol) AY972478 ENSMUST00000166290.1 uc288ycq.1 uc288ycq.2 uc288ycq.1 uc288ycq.2 
ENSMUST00000166303.9 Efemp2 ENSMUST00000166303.9 Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta (PubMed:16478991, PubMed:19855011, PubMed:20019329, PubMed:26486174, PubMed:26711913, PubMed:28508064). In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin (PubMed:26690653, PubMed:26711913, PubMed:26220971, PubMed:26178373). Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction (PubMed:17324935). Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling (PubMed:23636094). (from UniProt Q9WVJ9) BC012269 ENSMUST00000166303.1 ENSMUST00000166303.2 ENSMUST00000166303.3 ENSMUST00000166303.4 ENSMUST00000166303.5 ENSMUST00000166303.6 ENSMUST00000166303.7 ENSMUST00000166303.8 Efemp2 FBLN4_MOUSE Fbln4 Mbp1 Q9WVJ9 uc289qgf.1 uc289qgf.2 uc289qgf.3 Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta (PubMed:16478991, PubMed:19855011, PubMed:20019329, PubMed:26486174, PubMed:26711913, PubMed:28508064). In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin (PubMed:26690653, PubMed:26711913, PubMed:26220971, PubMed:26178373). Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction (PubMed:17324935). Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling (PubMed:23636094). Homodimer; disulfide-linked (By similarity). Multimer; allows heparin binding (By similarity). Monomer (PubMed:17324935). Binds preferentially to p53 mutants (PubMed:10380882). Interacts with FBN1 (via N-terminal domain); this interaction inhibits EFEMP2 binding to LOX and ELN (By similarity). Interacts with ELN with moderate affinity; this interaction regulates ELN self-assembly maturation stage (PubMed:16478991, PubMed:17324935). Interacts with PCOLCE (PubMed:26220971). Interacts with collagen type IV trimer (COL4A1- COL4A1-COL4A2), NID2 and moderately with COL15A1-derived endostatin (PubMed:17324935). Interacts with EMILIN1; this interaction promotes the incorporation of EFEMP2 into the extracellular matrix (PubMed:28717224). Interacts with LTBP4; the LTBP4 long form (LTBP4L) has a stronger binding affinity than the LTBP4 short form and the LTBP4 long form promotes fibrillar deposition of EFEMP2 (PubMed:25713297). Interacts with LOX (via propeptide); this interaction is strong and facilitates formation of ternary complexes with ELN during elastic fiber assembly; this interaction limits interaction of EFEMP2 with FBLN5 (By similarity). Interacts with PITX2 (By similarity). Interacts with FBLN5 with moderate affinity (By similarity). Interacts with LOXL1 (via propeptide), LTBP1 and TGFB1 stronger than with LOXL2 and LTBP3 (By similarity). Secreted, extracellular space, extracellular matrix creted, extracellular space, extracellular matrix, basement membrane Note=Localizes on the microfibrils surrounding ELN cores. Expressed in elastic fibers of the skin, near the dermal-epidermal junction, surrounding the hair follicles and throughout the dermis (PubMed:26178373). Expressed in tendon around tenocytes (PubMed:26711913). Prominently expressed in cartilage, bone, perichondrium and ligaments. Also detected in bone marrow stroma (PubMed:26690653). Expressed in aorta, lung, and esophagus (PubMed:17324935). At E(15), found in the perichondrium of the developing bone. At E(14) detected in the lung parenchyma. N-glycosylated; contains mostly complex-type glycans. Not O- glycosylated. Cleaved by ELANE; produces a 50-55 kDa fragment. Cleaved by MMP2 and MMP9; produces several fragments. Homozygous mice for the EFEMP2 gene appear to be outwardly normal (PubMed:16478991, PubMed:28508064). Homozygous mice exhibit severe lung and vascular defects including emphysema, artery tortuosity, irregularity, aneurysm, rupture, and resulting hemorrhages (PubMed:16478991, PubMed:19855011, PubMed:26178373, PubMed:28508064). Mice died perinatally (PubMed:16478991, PubMed:19855011). Mice with conditional knockout of EFEMP2, in vascular smooth muscle, grow normally, are fertile and exhibit an arterial stiffness (PubMed:19855011). Mice with conditional knockout of EFEMP2, in endothelial cell (EC) are healthy with an normal aorta (PubMed:20019329). Mice with conditional knockout of EFEMP2, in smooth muscle cells, die spontaneously at approximately 2 months of age despite absence of embryonic or neonatal lethality. Aortae exhibit large aneurysms exclusively in the ascending aorta. Aneurysms are observed with complete penetrance (PubMed:20019329, PubMed:26486174, PubMed:23636094, PubMed:26220971). Homozygous mice for the EFEMP2 gene die within 1-2 days after birth. Embryos at 19 dpc show bilateral forelimb contractures (PubMed:26711913, PubMed:26690653). Newborn homozygous mice demonstrate normal morphology of the skeleton (PubMed:26690653). Aneurysm may be prevent with postnatal administration of ACE inhibitor and/or angiotensin II receptor blocker (ARB). Belongs to the fibulin family. calcium ion binding protein binding extracellular region extracellular space extracellular matrix constituent conferring elasticity extracellular matrix elastic fiber assembly artery development uc289qgf.1 uc289qgf.2 uc289qgf.3 
ENSMUST00000166306.3 Gm2663 ENSMUST00000166306.3 predicted gene 2663 (from RefSeq NM_001102660.1) 1810009J06Rik ENSMUST00000166306.1 ENSMUST00000166306.2 F6R7E8 F6R7E8_MOUSE Gm2663 NM_001102660 uc009vds.1 uc009vds.2 uc009vds.3 serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc009vds.1 uc009vds.2 uc009vds.3 
ENSMUST00000166328.2 Gm17641 ENSMUST00000166328.2 Gm17641 (from geneSymbol) AK033123 ENSMUST00000166328.1 uc057bpy.1 uc057bpy.2 uc057bpy.3 uc057bpy.1 uc057bpy.2 uc057bpy.3 
ENSMUST00000166343.3 Glyatl3 ENSMUST00000166343.3 glycine-N-acyltransferase-like 3 (from RefSeq NM_001145060.2) E9Q5L8 ENSMUST00000166343.1 ENSMUST00000166343.2 GLYL3_MOUSE Glyatl3 NM_001145060 uc012atm.1 uc012atm.2 uc012atm.3 Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway. Reaction=an acyl-CoA + glycine = an N-acylglycine + CoA + H(+); Xref=Rhea:RHEA:19869, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57670, ChEBI:CHEBI:58342; EC=2.3.1.13; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z- octadecenoyl)glycine; Xref=Rhea:RHEA:51272, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57387, ChEBI:CHEBI:133992; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51273; Evidence=; Reaction=glycine + hexadecanoyl-CoA = CoA + H(+) + N- hexadecanoylglycine; Xref=Rhea:RHEA:58536, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57379, ChEBI:CHEBI:142655; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58537; Evidence=; Lipid metabolism. cellular_component mitochondrion biological_process transferase activity transferase activity, transferring acyl groups glycine N-acyltransferase activity uc012atm.1 uc012atm.2 uc012atm.3 
ENSMUST00000166355.3 Vmn2r74 ENSMUST00000166355.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PW21) E9PW21 E9PW21_MOUSE ENSMUST00000166355.1 ENSMUST00000166355.2 Vmn2r74 uc012foo.1 uc012foo.2 uc012foo.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein hematopoietic progenitor cell differentiation G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012foo.1 uc012foo.2 uc012foo.3 
ENSMUST00000166373.2 C030005K15Rik ENSMUST00000166373.2 C030005K15Rik (from geneSymbol) AK047662 ENSMUST00000166373.1 uc287ukb.1 uc287ukb.2 uc287ukb.1 uc287ukb.2 
ENSMUST00000166376.10 Mfap2 ENSMUST00000166376.10 microfibrillar-associated protein 2, transcript variant 2 (from RefSeq NM_001161799.3) ENSMUST00000166376.1 ENSMUST00000166376.2 ENSMUST00000166376.3 ENSMUST00000166376.4 ENSMUST00000166376.5 ENSMUST00000166376.6 ENSMUST00000166376.7 ENSMUST00000166376.8 ENSMUST00000166376.9 Magp1 Mfap2 NM_001161799 Q99PM0 Q99PM0_MOUSE uc012dny.1 uc012dny.2 uc012dny.3 uc012dny.4 Belongs to the MFAP family. Lacks conserved residue(s) required for the propagation of feature annotation. microfibril embryonic eye morphogenesis post-embryonic eye morphogenesis uc012dny.1 uc012dny.2 uc012dny.3 uc012dny.4 
ENSMUST00000166381.3 Cdr1 ENSMUST00000166381.3 Cdr1 (from geneSymbol) ENSMUST00000166381.1 ENSMUST00000166381.2 uc012hid.1 uc012hid.2 uc012hid.3 uc012hid.1 uc012hid.2 uc012hid.3 
ENSMUST00000166384.8 Sgk3 ENSMUST00000166384.8 serum/glucocorticoid regulated kinase 3, transcript variant 2 (from RefSeq NM_177547.3) Cisk ENSMUST00000166384.1 ENSMUST00000166384.2 ENSMUST00000166384.3 ENSMUST00000166384.4 ENSMUST00000166384.5 ENSMUST00000166384.6 ENSMUST00000166384.7 NM_177547 Q3UAY2 Q9ERE3 SGK3_MOUSE Sgkl uc007agv.1 uc007agv.2 uc007agv.3 uc007agv.4 Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Two specific sites, one in the kinase domain (Thr- 320) and the other in the C-terminal regulatory region (Ser-486), need to be phosphorylated for its full activation. Interacts with GSK3B and FLII. Interacts with PDPK1 in a phosphorylation-dependent manner. Cytoplasmic vesicle Early endosome Recycling endosome Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Colocalizes with SLC9A3/NHE3 in the recycling endosomes (By similarity). Localized in vesicle-like structures and in the early endosome. Widely expressed, predominantly in the heart, spleen and 7-day embryo. Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding endosome early endosome protein phosphorylation potassium channel regulator activity kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation cytoplasmic vesicle phosphatidylinositol binding intracellular signal transduction recycling endosome negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc007agv.1 uc007agv.2 uc007agv.3 uc007agv.4 
ENSMUST00000166411.8 Ssb ENSMUST00000166411.8 small RNA binding exonuclease protection factor La, transcript variant 15 (from RefSeq NR_185234.1) ENSMUST00000166411.1 ENSMUST00000166411.2 ENSMUST00000166411.3 ENSMUST00000166411.4 ENSMUST00000166411.5 ENSMUST00000166411.6 ENSMUST00000166411.7 NR_185234 Q564E6 Q564E6_MOUSE Ssb uc012bws.1 uc012bws.2 Nucleus tRNA binding tRNA 5'-leader removal nucleic acid binding RNA binding nucleus cytoplasm RNA processing tRNA export from nucleus tRNA processing poly(U) RNA binding tRNA 3'-end processing nuclear histone mRNA catabolic process IRES-dependent viral translational initiation protein localization to cytoplasmic stress granule sequence-specific mRNA binding ribonucleoprotein complex uc012bws.1 uc012bws.2 
ENSMUST00000166426.9 Bag6 ENSMUST00000166426.9 BCL2-associated athanogene 6, transcript variant 23 (from RefSeq NM_001372282.1) Bag6 Bat3 ENSMUST00000166426.1 ENSMUST00000166426.2 ENSMUST00000166426.3 ENSMUST00000166426.4 ENSMUST00000166426.5 ENSMUST00000166426.6 ENSMUST00000166426.7 ENSMUST00000166426.8 NM_001372282 Q3UF95 Q3UF95_MOUSE uc008cgc.1 uc008cgc.2 uc008cgc.3 uc008cgc.4 Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). Nucleus Secreted, extracellular exosome uc008cgc.1 uc008cgc.2 uc008cgc.3 uc008cgc.4 
ENSMUST00000166429.9 Sipa1l1 ENSMUST00000166429.9 signal-induced proliferation-associated 1 like 1, transcript variant 1 (from RefSeq NM_172579.4) ENSMUST00000166429.1 ENSMUST00000166429.2 ENSMUST00000166429.3 ENSMUST00000166429.4 ENSMUST00000166429.5 ENSMUST00000166429.6 ENSMUST00000166429.7 ENSMUST00000166429.8 Kiaa0440 NM_172579 Q6PDI8 Q80U02 Q8C026 Q8C0T5 SI1L1_MOUSE uc007ocu.1 uc007ocu.2 uc007ocu.3 uc007ocu.4 Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). Interacts with DLG4, PDLIM5, PDLIM7 and LZTS3. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Cytoplasm, cytoskeleton Postsynaptic density Synapse, synaptosome Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=E6TP1 alpha; IsoId=Q8C0T5-1; Sequence=Displayed; Name=2; IsoId=Q8C0T5-2; Sequence=VSP_010918, VSP_010919; Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2. Phosphorylated at Ser-1328 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome (By similarity). GTPase activator activity cytoplasm cytoskeleton plasma membrane postsynaptic density membrane protein kinase binding cell junction actin cytoskeleton reorganization ubiquitin protein ligase binding macromolecular complex neuron projection neuronal cell body regulation of GTPase activity dendritic spine macromolecular complex binding synapse postsynaptic membrane ephrin receptor binding ephrin receptor signaling pathway regulation of synaptic plasticity regulation of dendrite morphogenesis regulation of axonogenesis actin filament binding regulation of small GTPase mediated signal transduction regulation of dendritic spine morphogenesis activation of GTPase activity postsynapse postsynaptic actin cytoskeleton organization glutamatergic synapse uc007ocu.1 uc007ocu.2 uc007ocu.3 uc007ocu.4 
ENSMUST00000166457.8 Slc6a12 ENSMUST00000166457.8 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12, transcript variant 6 (from RefSeq NM_001381906.1) ENSMUST00000166457.1 ENSMUST00000166457.2 ENSMUST00000166457.3 ENSMUST00000166457.4 ENSMUST00000166457.5 ENSMUST00000166457.6 ENSMUST00000166457.7 G5E8Z4 G5E8Z4_MOUSE NM_001381906 Slc6a12 uc009dok.1 uc009dok.2 uc009dok.3 Reaction=2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) = 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in); Xref=Rhea:RHEA:71175, ChEBI:CHEBI:17750, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71176; Evidence=; Reaction=4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) = 4- aminobutanoate(in) + chloride(in) + 3 Na(+)(in); Xref=Rhea:RHEA:70731, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:59888; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70732; Evidence=; Interacts with LIN7C. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily. neurotransmitter:sodium symporter activity gamma-aminobutyric acid:sodium symporter activity integral component of plasma membrane neurotransmitter transport symporter activity gamma-aminobutyric acid transport membrane integral component of membrane transmembrane transport uc009dok.1 uc009dok.2 uc009dok.3 
ENSMUST00000166468.2 Ptprk ENSMUST00000166468.2 protein tyrosine phosphatase receptor type K, transcript variant 2 (from RefSeq NM_008983.2) ENSMUST00000166468.1 NM_008983 P35822 PTPRK_MOUSE Ptpk uc007esn.1 uc007esn.2 Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Membrane; Single-pass type I membrane protein. High levels in liver and kidney. Lower levels in lung, brain and heart. Not seen in spleen and testis. Developmentally regulated with highest expression found in developing areas or in areas capable of developmental plasticity. This protein undergoes proteolytic processing. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. photoreceptor outer segment phosphoprotein phosphatase activity protein tyrosine phosphatase activity plasma membrane cell-cell junction protein dephosphorylation cell adhesion signal transduction transforming growth factor beta receptor signaling pathway beta-catenin binding negative regulation of cell proliferation cell surface negative regulation of keratinocyte proliferation membrane integral component of membrane dephosphorylation cell migration hydrolase activity phosphatase activity protein kinase binding cell junction negative regulation of cell migration axon dendrite neuron projection development leading edge membrane protein localization to cell surface cellular response to reactive oxygen species cellular response to UV peptidyl-tyrosine dephosphorylation neuronal cell body intracellular membrane-bounded organelle gamma-catenin binding negative regulation of cell cycle negative regulation of transcription, DNA-templated focal adhesion assembly uc007esn.1 uc007esn.2 
ENSMUST00000166487.10 Dnajb11 ENSMUST00000166487.10 DnaJ heat shock protein family (Hsp40) member B11, transcript variant 1 (from RefSeq NM_026400.5) A6X957 DJB11_MOUSE ENSMUST00000166487.1 ENSMUST00000166487.2 ENSMUST00000166487.3 ENSMUST00000166487.4 ENSMUST00000166487.5 ENSMUST00000166487.6 ENSMUST00000166487.7 ENSMUST00000166487.8 ENSMUST00000166487.9 NM_026400 Q543I7 Q8BK79 Q8VCY1 Q8VHB1 Q99KV1 uc007ysp.1 uc007ysp.2 uc007ysp.3 uc007ysp.4 As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Binds to denatured substrates in an ATP-independent manner. Interacts via the J domain with HSPA5 in an ATP-dependent manner (By similarity). Q99KV1; P20029: Hspa5; NbExp=4; IntAct=EBI-8328260, EBI-772325; Endoplasmic reticulum lumen Contains high-mannose Endo H-sensitive carbohydrates. Cys-169, Cys-171, Cys-193 and Cys-196 form intramolecular disulfide bonds. The preferential partner for each Cys is not known (By similarity). PubMed:11584023 reported a cytosolic, as well as nuclear subcellular location. This result was obtained using an N-terminally GFP-tagged construct which most probably affected signal peptide-driven targeting to the ER. As a consequence, the in vivo revelance of the observed interaction with APOBEC1, a nuclear protein, is dubious. receptor binding protein binding extracellular space nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum lumen protein folding mRNA modification positive regulation of ATPase activity endoplasmic reticulum chaperone complex negative regulation of neurogenesis unfolded protein binding protein maturation uc007ysp.1 uc007ysp.2 uc007ysp.3 uc007ysp.4 
ENSMUST00000166489.8 Ube2j2 ENSMUST00000166489.8 ubiquitin-conjugating enzyme E2J 2, transcript variant 4 (from RefSeq NM_001039159.2) ENSMUST00000166489.1 ENSMUST00000166489.2 ENSMUST00000166489.3 ENSMUST00000166489.4 ENSMUST00000166489.5 ENSMUST00000166489.6 ENSMUST00000166489.7 NM_001039159 Ncube2 Q6P073 Q8C6A1 Q91Y64 Q9CWY5 Q9DC18 Q9QX58 UB2J2_MOUSE uc008wfn.1 uc008wfn.2 uc008wfn.3 uc008wfn.4 Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (PubMed:12082160). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2 (By similarity). In case of infection by the murid herpesvirus 4, its association with the viral E3 ligase K3 mediates ubiquitination of host surface class I (MHC-I) H-2D(b)/H2-D1 and H-2K(b)/H2-K1 molecules before they exit the endoplasmic reticulum, leading to their degradation by the ERAD system, thus blocking the immune detection of virus-infected cells. The complex formed with the murid herpesvirus 4 protein K3 mediates ubiquitination of lysine, as well as serine and threonine residues present in the cytoplasmic tail of surface class I molecules and promotes ubiquitination of hydroxylated serine or threonine residues via ester bonds instead of the classical isopeptide linkage. Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence=; Protein modification; protein ubiquitination. Interacts with murid herpesvirus 4 protein K3 (mK3). Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Belongs to the ubiquitin-conjugating enzyme family. ubiquitin ligase complex nucleotide binding protein polyubiquitination ATP binding endoplasmic reticulum endoplasmic reticulum membrane response to unfolded protein membrane integral component of membrane protein ubiquitination transferase activity ER-associated ubiquitin-dependent protein catabolic process ubiquitin protein ligase binding ubiquitin conjugating enzyme activity uc008wfn.1 uc008wfn.2 uc008wfn.3 uc008wfn.4 
ENSMUST00000166493.8 Gm6676 ENSMUST00000166493.8 Gm6676 (from geneSymbol) ENSMUST00000166493.1 ENSMUST00000166493.2 ENSMUST00000166493.3 ENSMUST00000166493.4 ENSMUST00000166493.5 ENSMUST00000166493.6 ENSMUST00000166493.7 Gm16434 Gm6676 K7N6G4 K7N6G4_MOUSE uc288qpv.1 uc288qpv.2 molecular_function cellular_component biological_process uc288qpv.1 uc288qpv.2 
ENSMUST00000166494.2 Gm2897 ENSMUST00000166494.2 predicted gene 2897 (from RefSeq NM_001177715.2) ENSMUST00000166494.1 Gm2897 K7N6T7 K7N6T7_MOUSE NM_001177715 uc007sam.1 uc007sam.2 uc007sam.3 uc007sam.4 uc007sam.5 uc007sam.1 uc007sam.2 uc007sam.3 uc007sam.4 uc007sam.5 
ENSMUST00000166497.9 Abhd6 ENSMUST00000166497.9 abhydrolase domain containing 6, transcript variant 1 (from RefSeq NM_025341.4) ABHD6_MOUSE Abhd6 ENSMUST00000166497.1 ENSMUST00000166497.2 ENSMUST00000166497.3 ENSMUST00000166497.4 ENSMUST00000166497.5 ENSMUST00000166497.6 ENSMUST00000166497.7 ENSMUST00000166497.8 NM_025341 Q3TGD2 Q8R2Y0 Q9DCD4 uc007sen.1 uc007sen.2 uc007sen.3 Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:18096503, PubMed:20657592). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (PubMed:18096503, PubMed:20657592). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (PubMed:24095738). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015). Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.; EC=3.1.1.23; Evidence= Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26133; Evidence=; Reaction=1-octanoylglycerol + H2O = glycerol + H(+) + octanoate; Xref=Rhea:RHEA:44328, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:25646, ChEBI:CHEBI:85241; Evidence=; Reaction=1-decanoylglycerol + H2O = decanoate + glycerol + H(+); Xref=Rhea:RHEA:44320, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:27689, ChEBI:CHEBI:75547; Evidence=; Reaction=1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+); Xref=Rhea:RHEA:44316, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:18262, ChEBI:CHEBI:75539; Evidence=; Reaction=1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate; Xref=Rhea:RHEA:44312, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30807, ChEBI:CHEBI:75562; Evidence=; Reaction=2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:39963, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:75455; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38491, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:73990; Evidence=; Reaction=1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38488; Evidence=; Reaction=2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)- octadecadienoate + glycerol + H(+); Xref=Rhea:RHEA:44732, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30245, ChEBI:CHEBI:75457; Evidence=; Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:44728, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:75612; Evidence=; Reaction=1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)- octadecadienoate + glycerol + H(+); Xref=Rhea:RHEA:48428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30245, ChEBI:CHEBI:75568; Evidence=; Reaction=3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z- octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 3-(9Z- octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+); Xref=Rhea:RHEA:55712, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:139150, ChEBI:CHEBI:139152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55713; Evidence=; Reaction=(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z- octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + (S,S)-2- (9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+); Xref=Rhea:RHEA:55716, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:139156, ChEBI:CHEBI:139157; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55717; Evidence=; Reaction=(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z- octadecenoyl)-3'-sn-glycerol) + H2O = (9Z)-octadecenoate + (R,R)-2- (9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+); Xref=Rhea:RHEA:55804, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:139228, ChEBI:CHEBI:139230; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55805; Evidence=; Kinetic parameters: KM=1.9 uM for 1(3)-monoolein ; KM=0.75 uM for 1-oleoyl lysophosphatidylglycerol (in presence of 5M CHAPS) ; KM=0.98 mM for (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'- (9Z-octadecenoyl)-3'-sn-glycerol) ; KM=0.9 mM for racemic monoolein ; KM=1.1 mM for lysophosphatidylglycerol ; Vmax=478.6 umol/h/mg enzyme toward 1(3)-monoolein ; Vmax=93.2 umol/h/mg enzyme toward 1-oleoyl lysophosphatidylglycerol ; Vmax=89 umol/h/mg enzyme toward lysophosphatidylglycerol ; Vmax=348 umol/h/mg enzyme toward (R,R)-2-(9Z-octadecenoyl)-sn- glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) ; Vmax=806 umol/h/mg enzyme toward 1-(9Z-octadecenoyl)-glycerol ; pH dependence: Optimum pH is 7.5-8.0. ; Late endosome membrane ; Single-pass type II membrane protein Lysosome membrane ; Single- pass type II membrane protein Mitochondrion membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R2Y0-1; Sequence=Displayed; Name=2; IsoId=Q8R2Y0-2; Sequence=VSP_024012; Widely expressed with higher expression in small intestine, liver and brown adipose tissue (PubMed:24095738). In brain, expressed postsynaptically in cortical neurons but not detected in microglia (at protein level) (PubMed:20657592). Up-regulated in small intestine and liver by high-fat diet. Abhd6 partial knockdown inducing a stronger depletion in liver, kidney and white adipose tissues protects mice against hight-fat diet-induced metabolic disorder and obesity. De novo lipogenesis in liver is reduced and associated with a reduced expression of lipogenic genes. Accumulation of phospholipids and lysophospholipds in the liver is also observed. Belongs to the AB hydrolase superfamily. Sequence=BAE40616.1; Type=Erroneous initiation; Evidence=; Sequence=BAE40616.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; catalytic activity phospholipase activity mitochondrion lysosome lysosomal membrane endosome lipid metabolic process phospholipid catabolic process membrane integral component of membrane hydrolase activity negative regulation of cell migration late endosome membrane mitochondrial membrane AMPA glutamate receptor complex acylglycerol catabolic process positive regulation of lipid biosynthetic process acylglycerol lipase activity monoacylglycerol catabolic process long term synaptic depression glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane regulation of endocannabinoid signaling pathway lysobisphosphatidic acid metabolic process uc007sen.1 uc007sen.2 uc007sen.3 
ENSMUST00000166499.4 Vmn2r44 ENSMUST00000166499.4 vomeronasal 2, receptor 44, transcript variant 1 (from RefSeq NM_001385059.1) ENSMUST00000166499.1 ENSMUST00000166499.2 ENSMUST00000166499.3 L7N2E1 L7N2E1_MOUSE NM_001385059 Vmn2r44 uc012eyh.1 uc012eyh.2 uc012eyh.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012eyh.1 uc012eyh.2 uc012eyh.3 
ENSMUST00000166543.10 Ralbp1 ENSMUST00000166543.10 ralA binding protein 1, transcript variant 1 (from RefSeq NM_009067.5) ENSMUST00000166543.1 ENSMUST00000166543.2 ENSMUST00000166543.3 ENSMUST00000166543.4 ENSMUST00000166543.5 ENSMUST00000166543.6 ENSMUST00000166543.7 ENSMUST00000166543.8 ENSMUST00000166543.9 NM_009067 Q62172 Q6NXH5 Q9CRE5 RBP1_MOUSE Ralbp1 Rip1 uc008dgo.1 uc008dgo.2 uc008dgo.3 uc008dgo.4 uc008dgo.5 uc008dgo.6 Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:8570186). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (By similarity). Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. Reaction=an S-substituted glutathione(in) + ATP + H2O = ADP + an S- substituted glutathione(out) + H(+) + phosphate; Xref=Rhea:RHEA:19121, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:90779, ChEBI:CHEBI:456216; EC=7.6.2.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19122; Evidence=; Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.; EC=7.6.2.2; Evidence=; Reaction=ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate; Xref=Rhea:RHEA:38963, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57973, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38964; Evidence=; Interacts with the GTP-bound form of RALA (via effector domain); during mitosis, recruits RALBP1 to the mitochondrion where it promotes DNM1L phosphorylation and mitochondrial fission. Interacts with DNM1L; mediates its mitotic kinase cyclin B-CDK1-mediated phosphorylation during mitosis to promote mitochondrial fission. Interacts with the mitotic kinase cyclin B-CDK1 during mitosis. Interacts with the GTP-bound form of RALB (via effector domain) (By similarity). Interacts with REPS1; the interaction is direct and does not affect RALA-binding nor GTPase activator activity of RALBP1 (PubMed:9395447). Interacts with REPS2; the interaction is direct and does not affect RALA-binding nor GTPase activator activity of RALBP1 (By similarity). Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis. Interacts with AP2M1; as part of the AP2 complex (PubMed:10910768). Interacts with CDC42. Interacts with RAC1 (By similarity). Q62172; Q06A28: RIR1; Xeno; NbExp=2; IntAct=EBI-8392197, EBI-9826498; Cell membrane ; Peripheral membrane protein Cytoplasm, cytosol Cytoplasm, cytoskeleton, spindle pole Nucleus Mitochondrion Note=Cytosolic protein that transiently associates with the mitotic spindle poles in early prophase, and dissociates from them after completion of mitosis (By similarity). Targeted to the plasma membrane through its interaction with RALB, directed by FGF signaling. Docking on the membrane is required to transduce the Ral signal (By similarity). Recruited by RALA to the mitochondrion during mitosis where it regulates mitochondrial fission. Nuclear localization is cell cycle dependent while membrane localization is seen in adherent cells. The region involved in membrane association could form transmembrane domains and expose a part of the protein extracellularly (By similarity). Ubiquitous. The highest level of expression was observed in ovaries and skeletal muscle, whereas the lowest was found in spleen, liver and peripheral blood leukocytes. The Rho-GAP domain mediates the GTPase activator activity toward CDC42. Tyrosine-phosphorylated upon stimulation of cells with EGF. May undergo proteolytic cleavage to give peptides which reassemble to form a transporter complex. GTPase activator activity protein binding plasma membrane endocytosis mitotic spindle organization signal transduction small GTPase mediated signal transduction membrane Ral GTPase binding transmembrane transporter activity ATPase activity, coupled to transmembrane movement of substances xenobiotic transporter activity neuron projection regulation of GTPase activity positive regulation of GTPase activity Rac GTPase binding negative regulation of smooth muscle cell proliferation transmembrane transport doxorubicin transport positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway drug transmembrane export uc008dgo.1 uc008dgo.2 uc008dgo.3 uc008dgo.4 uc008dgo.5 uc008dgo.6 
ENSMUST00000166581.4 Fga ENSMUST00000166581.4 fibrinogen alpha chain, transcript variant 1 (from RefSeq NM_001111048.2) E9PV24 ENSMUST00000166581.1 ENSMUST00000166581.2 ENSMUST00000166581.3 FIBA_MOUSE Fga NM_001111048 Q99K47 uc012cqw.1 uc012cqw.2 uc012cqw.3 uc012cqw.4 This gene encodes a subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded protein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mice lacking the encoded protein display bleeding in the peritoneal cavity, skin and soft tissues around joints immediately after birth, and are predisposed to spontaneous fatal abdominal hemorrhage as they grow. Pregnant mice lacking the encoded protein succumb to uterine bleeding during gestation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]. Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots (PubMed:7649481). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (PubMed:11389004). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood (PubMed:7649481). However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (PubMed:10930441). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (PubMed:7649481). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (PubMed:12629066). May also facilitate the immune response via both innate and T-cell mediated pathways (PubMed:23487423). Heterohexamer; disulfide linked. Contains 2 sets of 3 non- identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9PV24-1; Sequence=Displayed; Name=2; IsoId=E9PV24-2; Sequence=VSP_057097, VSP_057098; Expressed in liver. A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure. Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers. Phosphorylated by FAM20C in the extracellular medium. Knockout mice are viable but only males are fertile (PubMed:7649481). Neonates frequently develop spontaneous hemorrhages, but in spite of this over 90% of mice survive the neonatal period (PubMed:7649481). However only half survive beyond 70 days of age; lethality is most often due to intra-abdominal hemorrhage (PubMed:7649481). Pregnancy in female mice fails at around 10 days of gestation, associated with severe intrauterine bleeding (PubMed:7649481). Secondary loss of FGB and FGG from circulating blood is observed, although FGB and FGG mRNA is normally expressed in hepatocytes (thought to be the main site of fibrinogen synthesis) (PubMed:7649481). In vitro, blood fails to clot and platelet aggregations do not form (PubMed:7649481). In vivo, platelet aggregation in injured arterioles initially occurs normally although thrombi are unstable and readily embolize (PubMed:10930441). In double knockouts of FGA and VWF, platelet aggregation is delayed and thrombi frequently embolize (PubMed:10930441). Mice succumb more rapidly to Y. pestis infection, associated with increased bacterial loads in liver and lung; however induction of the inflammatory response factors TNF, IFNG, CXCL1, and LCN2 is not affected (PubMed:23487423). Mice succumb more rapidly to T. gondii infection, with increased hemorrhagic pathology; however parasite numbers are not significantly increased and induction of the inflammatory response markers IL12, IFNG, TNF, IL10, and nitric oxide is not affected (PubMed:12629066). Mice succumb more rapidly to L. monocytogenes infection, with increased hemorrhagic pathology and increased bacterial burdens in hepatic tissue; however there is little effect on peritoneal bacterial numbers or bacterial dissemination to other tissues, and also no effect on induction of the inflammatory markers IFNG, TNF and NOS2 (PubMed:15972474). adaptive immune response immune system process receptor binding structural molecule activity extracellular matrix structural constituent extracellular region fibrinogen complex extracellular space cytoplasm rough endoplasmic reticulum cell cortex cell-matrix adhesion blood coagulation hemostasis external side of plasma membrane cell surface positive regulation of smooth muscle cell migration platelet activation platelet alpha granule plasminogen activation positive regulation of heterotypic cell-cell adhesion cellular macromolecular complex assembly fibrinolysis induction of bacterial agglutination innate immune response synapse positive regulation of vasoconstriction positive regulation of exocytosis metal ion binding positive regulation of protein secretion protein polymerization response to calcium ion macromolecular complex assembly positive regulation of ERK1 and ERK2 cascade platelet aggregation blood coagulation, common pathway blood coagulation, fibrin clot formation blood microparticle positive regulation of peptide hormone secretion negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of endothelial cell apoptotic process cell adhesion molecule binding uc012cqw.1 uc012cqw.2 uc012cqw.3 uc012cqw.4 
ENSMUST00000166593.2 Gm17134 ENSMUST00000166593.2 Gm17134 (from geneSymbol) ENSMUST00000166593.1 uc029qzz.1 uc029qzz.2 uc029qzz.3 uc029qzz.1 uc029qzz.2 uc029qzz.3 
ENSMUST00000166599.2 Lpcat2b ENSMUST00000166599.2 lysophosphatidylcholine acyltransferase 2B (from RefSeq NM_027599.3) Aytl1b ENSMUST00000166599.1 NM_027599 PCT2B_MOUSE Q9D5U0 uc008ymf.1 uc008ymf.2 Probable acetyltransferase. Lipid metabolism; phospholipid metabolism. Membrane ; Multi-pass membrane protein The HXXXXD motif is essential for acyltransferase activity. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. calcium ion binding cellular_component lipid metabolic process phospholipid metabolic process biological_process phospholipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups metal ion binding uc008ymf.1 uc008ymf.2 
ENSMUST00000166606.3 Gm17092 ENSMUST00000166606.3 Gm17092 (from geneSymbol) ENSMUST00000166606.1 ENSMUST00000166606.2 uc290xkw.1 uc290xkw.2 uc290xkw.3 uc290xkw.1 uc290xkw.2 uc290xkw.3 
ENSMUST00000166615.3 Wwp2 ENSMUST00000166615.3 WW domain containing E3 ubiquitin protein ligase 2 (from RefSeq NM_025830.4) ENSMUST00000166615.1 ENSMUST00000166615.2 NM_025830 Q8BTG4 Q923F6 Q9DBH0 WWP2_MOUSE uc009nhv.1 uc009nhv.2 uc009nhv.3 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; regulates POU5F1 protein level during differentiation of embryonal carcinoma cells (ECCs) but not in undifferentiated ECCs and embryonic stem cells (ESCs). Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Activated by NDFIP1- and NDFIP2-binding. Protein modification; protein ubiquitination. Interacts with SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2 and ATN1. Interacts with ERBB4, NDFIP1 and NDFIP2. Interacts with ARRDC4 (By similarity). Interacts with POU5F1, RBP1, EGR2 and SLC11A2. Interacts (via WW domains) with ARRDC1 (via PPxY motifs); ubiquitinates ARRDC1 (By similarity). Interacts (via WW domains) with ARRDC2 and ARRDC3 (By similarity). Nucleus The C2 domain is involved in autoinhibition of the catalytic activity by interacting with the HECT domain. The WW domains mediate interaction with PPxY motif-containing proteins. Autoubiquitinated. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome (By similarity). A cysteine residue is required for ubiquitin-thioester formation. negative regulation of transcription from RNA polymerase II promoter protein polyubiquitination RNA polymerase II transcription factor binding ubiquitin-protein transferase activity protein binding extracellular region nucleus cytoplasm ubiquitin-dependent protein catabolic process extracellular transport transcription factor binding negative regulation of gene expression protein ubiquitination transferase activity negative regulation of transporter activity regulation of ion transmembrane transport regulation of membrane potential proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of protein catabolic process negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of protein transport protein autoubiquitination ubiquitin protein ligase activity protein K63-linked ubiquitination regulation of potassium ion transmembrane transporter activity uc009nhv.1 uc009nhv.2 uc009nhv.3 
ENSMUST00000166623.10 Apol11b ENSMUST00000166623.10 apolipoprotein L 11b (from RefSeq NM_001143686.1) Apol11b E9PUZ0 E9PUZ0_MOUSE ENSMUST00000166623.1 ENSMUST00000166623.2 ENSMUST00000166623.3 ENSMUST00000166623.4 ENSMUST00000166623.5 ENSMUST00000166623.6 ENSMUST00000166623.7 ENSMUST00000166623.8 ENSMUST00000166623.9 NM_001143686 uc011zvj.1 uc011zvj.2 uc011zvj.3 Belongs to the apolipoprotein L family. cellular_component extracellular region lipid transport biological_process lipid binding lipoprotein metabolic process uc011zvj.1 uc011zvj.2 uc011zvj.3 
ENSMUST00000166627.8 Zfp414 ENSMUST00000166627.8 zinc finger protein 414, transcript variant 2 (from RefSeq NR_034153.1) ENSMUST00000166627.1 ENSMUST00000166627.2 ENSMUST00000166627.3 ENSMUST00000166627.4 ENSMUST00000166627.5 ENSMUST00000166627.6 ENSMUST00000166627.7 NR_034153 Q8CHU9 Q9DCK4 ZN414_MOUSE Znf414 uc008byy.1 uc008byy.2 uc008byy.3 uc008byy.4 uc008byy.5 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DCK4-1; Sequence=Displayed; Name=2; IsoId=Q9DCK4-2; Sequence=VSP_019454; Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus biological_process metal ion binding uc008byy.1 uc008byy.2 uc008byy.3 uc008byy.4 uc008byy.5 
ENSMUST00000166637.2 Gm17226 ENSMUST00000166637.2 Gm17226 (from geneSymbol) ENSMUST00000166637.1 uc292hkn.1 uc292hkn.2 uc292hkn.1 uc292hkn.2 
ENSMUST00000166650.3 Ptprh ENSMUST00000166650.3 protein tyrosine phosphatase receptor type H (from RefSeq NM_207270.2) B6ZDS3 E9Q0N2 ENSMUST00000166650.1 ENSMUST00000166650.2 NM_207270 PTPRH_MOUSE Ptprh Q8BIW7 SAP-1 uc009exz.1 uc009exz.2 uc009exz.3 Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin- promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of Jurkat cells (By similarity). Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response (PubMed:26195794). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Homodimer; disulfide-linked (By similarity). Interacts with LCK (By similarity). Interacts (phosphorylated form) with GRB2 (via SH2 domain) (PubMed:20398064). Interacts (phosphorylated form) with FYN (via SH2 domain) (PubMed:20398064). Interacts (via extracellular domain) with CEACAM20 (via extracellular domain); the interaction dephosphorylates CEACAM20 (PubMed:26195794). Cell projection, microvillus membrane ; Single-pass type I membrane protein Cytoplasm Apical cell membrane ; Single-pass type I membrane protein Note=Colocalizes with CEACAM20 at the apical brush border of intestinal cells. Expressed strongly in the intestinal tract, with particularly high levels in the duodenum and jejunum (at protein level). Also expressed at low level in the testis (at protein level). Not detected in other tissues tested (at protein level). Detected from embryonic stage 16.5 dpc onwards, with marked increase in expression level after birth. Viable and fertile (PubMed:19170756). No significant effect on body weight or nutrient absorption (PubMed:19170756). Morphology of intestinal epithelium cells appears to be normal (PubMed:19170756). Double knockouts with APC heterozygotes, a model for intestinal tumorigenesis, show reduced adenoma growth (PubMed:19170756). Double knockouts with IL10, a model of inflammatory bowel disease, show significantly increased colonic inflammation in the presence of commensal bacteria and reduced survival rates (PubMed:26195794). Sequence=BAC37443.1; Type=Frameshift; Evidence=; phosphoprotein phosphatase activity protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding cytoplasm plasma membrane microvillus protein dephosphorylation membrane integral component of membrane dephosphorylation apical plasma membrane hydrolase activity phosphatase activity microvillus membrane peptidyl-tyrosine dephosphorylation cell projection cadherin binding uc009exz.1 uc009exz.2 uc009exz.3 
ENSMUST00000166658.8 Pfdn5 ENSMUST00000166658.8 prefoldin 5 (from RefSeq NM_027044.3) ENSMUST00000166658.1 ENSMUST00000166658.2 ENSMUST00000166658.3 ENSMUST00000166658.4 ENSMUST00000166658.5 ENSMUST00000166658.6 ENSMUST00000166658.7 Eig1 Mm1 NM_027044 PFD5_MOUSE Pfd5 Q3UKS8 Q9JMJ8 Q9WU28 uc007xvh.1 uc007xvh.2 uc007xvh.3 uc007xvh.4 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC (By similarity). Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Nucleus Belongs to the prefoldin subunit alpha family. Sequence=BAA92269.1; Type=Erroneous initiation; Evidence=; nucleus cytoplasm protein folding prefoldin complex negative regulation of transcription, DNA-templated unfolded protein binding retina development in camera-type eye negative regulation of canonical Wnt signaling pathway uc007xvh.1 uc007xvh.2 uc007xvh.3 uc007xvh.4 
ENSMUST00000166664.2 S2bpcox16 ENSMUST00000166664.2 synaptojanin 2 binding protein Cox16 readthrough, transcript variant 1 (from RefSeq NM_001309847.1) E9PVN6 E9PVN6_MOUSE ENSMUST00000166664.1 NM_001309847 S2bpcox16 uc007ocf.1 uc007ocf.2 uc007ocf.3 uc007ocf.4 This locus represents naturally occurring readthrough transcription between the neighboring Synj2bp (synaptojanin 2 binding protein) and Cox16 (cytochrome c oxidase assembly protein 16) genes on chromosome 12. The readthrough transcripts encode fusion proteins that share sequence similarity with each individual gene product. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2015]. Membrane ; Single- pass membrane protein Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the COX16 family. mitochondrial membrane uc007ocf.1 uc007ocf.2 uc007ocf.3 uc007ocf.4 
ENSMUST00000166674.2 Gm17026 ENSMUST00000166674.2 predicted gene 17026 (from RefSeq NM_001378714.1) ENSMUST00000166674.1 Gm17026 K7N6Z0 K7N6Z0_MOUSE NM_001378714 uc033gpi.1 uc033gpi.2 uc033gpi.3 uc033gpi.1 uc033gpi.2 uc033gpi.3 
ENSMUST00000166687.6 Rusc1 ENSMUST00000166687.6 RUN and SH3 domain containing 1, transcript variant 3 (from RefSeq NM_001083808.1) ENSMUST00000166687.1 ENSMUST00000166687.2 ENSMUST00000166687.3 ENSMUST00000166687.4 ENSMUST00000166687.5 NM_001083808 Nesca Q6PHT9 Q8BG26 RUSC1_MOUSE Rusc1 uc008pxl.1 uc008pxl.2 uc008pxl.3 uc008pxl.4 Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Signaling adapter which plays a role in neuronal differentiation. Involved in regulation of NGF-dependent neurite outgrowth (By similarity). May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (PubMed:22404429). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway (By similarity). Associated component of the adapter-like complex 4 (AP-4) (By similarity). Interacts with IKBKG and TRAF6 (By similarity). Interacts with F-actin, acetylated actin, TUBB3, STX1A, KIF5B and KLC1 (PubMed:22404429). Cytoplasm Nucleus Cytoplasm, cytoskeleton Cytoplasmic vesicle Early endosome Postsynaptic density Golgi apparatus Note=Translocated to the nuclear envelope upon stimulation with NGF (By similarity). Associated with membranes and microtubules (PubMed:22404429). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BG26-1; Sequence=Displayed; Name=2; IsoId=Q8BG26-2; Sequence=VSP_010856; Name=3; IsoId=Q8BG26-3; Sequence=VSP_010857; Expressed in brain, brain stem and spinal cord (at protein level). Expressed at 15 dpc in hippocampal, cortical and cerebellar brain, and brain stem and spinal cord. At 18 dpc, expression strongly overlaps with TUBB3 expression in post-mitotic neurons throughout the entire brain. Expression levels increase to 18 dpc/P1 after which the levels decline in the hippocampus, cerebellum and brain stem and spinal cord into adulthood while remaining high in the cortex. The RUN domain is necessary for NGF induced nuclear redistribution. Phosphorylated on serine residues following nuclear translocation. Polyubiquitinated; polyubiquitination involves TRAF6. Sequence=BAC27820.1; Type=Erroneous initiation; Evidence=; Sequence=BAC30411.1; Type=Erroneous initiation; Evidence=; Sequence=BAC31333.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; protein polyubiquitination actin binding nucleus cytoplasm endosome early endosome Golgi apparatus cytosol cytoskeleton microtubule plasma membrane postsynaptic density microtubule cytoskeleton membrane cell junction cytoplasmic vesicle synapse postsynaptic membrane uc008pxl.1 uc008pxl.2 uc008pxl.3 uc008pxl.4 
ENSMUST00000166692.2 Spmip5 ENSMUST00000166692.2 sperm microtubule inner protein 5, transcript variant 3 (from RefSeq NM_001368689.1) ENSMUST00000166692.1 NM_001368689 Q9CQT6 SMIP5_MOUSE uc289snj.1 uc289snj.2 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella. Cytoplasm, cytoskeleton, flagellum axoneme Cytoplasm Nucleus Note=Localizes to the A-tubules of DMTs (By similarity). Located in the cytoplasm of spermatocytes and the nuclei of round spermatids and elongated spermatids (PubMed:25609838). Expressed in testis (at protein level). Sequence=AAH49561.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB24426.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB24581.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process uc289snj.1 uc289snj.2 
ENSMUST00000166713.9 Cpeb2 ENSMUST00000166713.9 cytoplasmic polyadenylation element binding protein 2, transcript variant 4 (from RefSeq NM_001368806.1) Cpeb2 E9Q969 E9Q969_MOUSE ENSMUST00000166713.1 ENSMUST00000166713.2 ENSMUST00000166713.3 ENSMUST00000166713.4 ENSMUST00000166713.5 ENSMUST00000166713.6 ENSMUST00000166713.7 ENSMUST00000166713.8 NM_001368806 uc290vda.1 uc290vda.2 uc290vda.3 Belongs to the RRM CPEB family. nucleic acid binding RNA binding mRNA 3'-UTR binding regulation of translation translation regulator activity uc290vda.1 uc290vda.2 uc290vda.3 
ENSMUST00000166714.3 Scgb1b20 ENSMUST00000166714.3 secretoglobin, family 1B, member 20 (from RefSeq NM_001270543.1) Abpa20 E9PWZ2 E9PWZ2_MOUSE ENSMUST00000166714.1 ENSMUST00000166714.2 Gm5895 NM_001270543 Scgb1b11 Scgb1b20 uc033iyt.1 uc033iyt.2 uc033iyt.3 Secreted steroid binding extracellular region biological_process uc033iyt.1 uc033iyt.2 uc033iyt.3 
ENSMUST00000166729.2 Galnt5 ENSMUST00000166729.2 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity). (from UniProt Q8C102) A2AS75 AK029323 ENSMUST00000166729.1 GALT5_MOUSE Q8C102 uc289wfg.1 uc289wfg.2 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity). Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Interacts with EXT2. Does not interact with EXT1, EXTL1 or EXTL3 (By similarity). Golgi apparatus membrane ; Single- pass type II membrane protein Expressed at low level. Not expressed before E7.5 during embryogenesis. Expressed in dental mesenchyme and tongue. Accumulates in a subset of mesenchymal cells at the ventral-most portions of the 12.5 dpc maxilla and mandible underlying the dental lamina. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Name=Functional Glycomics Gateway - GTase; Note=Polypeptide N-acetylgalactosaminyltransferase 5; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_514"; Golgi membrane polypeptide N-acetylgalactosaminyltransferase activity Golgi apparatus protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups carbohydrate binding metal ion binding uc289wfg.1 uc289wfg.2 
ENSMUST00000166737.2 Zfp488 ENSMUST00000166737.2 zinc finger protein 488 (from RefSeq NM_001013777.3) ENSMUST00000166737.1 Gm1206 NM_001013777 Q5HZG9 ZN488_MOUSE Znf488 uc007tae.1 uc007tae.2 Transcriptional repressor (PubMed:16908628). Plays a role in oligodendrocyte differentiation, together with OLIG2 (PubMed:16908628, PubMed:22355521). Mediates Notch signaling-activated formation of oligodendrocyte precursors (PubMed:16908628). Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury (PubMed:22355521). Interacts with OLIG2. Nucleus Detected in differentiated oligodendrocytes, from embryos at 14.5 dpc through to the postnatal stage. Up-regulated by OLIG1. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAH89025.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleic acid binding DNA binding protein binding nucleus nervous system development oligodendrocyte development positive regulation of myelination negative regulation of transcription, DNA-templated metal ion binding positive regulation of oligodendrocyte differentiation uc007tae.1 uc007tae.2 
ENSMUST00000166743.9 Mapk1ip1l ENSMUST00000166743.9 mitogen-activated protein kinase 1 interacting protein 1-like, transcript variant 1 (from RefSeq NM_178684.6) ENSMUST00000166743.1 ENSMUST00000166743.2 ENSMUST00000166743.3 ENSMUST00000166743.4 ENSMUST00000166743.5 ENSMUST00000166743.6 ENSMUST00000166743.7 ENSMUST00000166743.8 MISSL_MOUSE NM_178684 Q3TF12 Q3TGL0 Q8BH93 Q8CC90 uc007thy.1 uc007thy.2 uc007thy.3 Belongs to the MISS family. molecular_function cellular_component biological_process uc007thy.1 uc007thy.2 uc007thy.3 
ENSMUST00000166746.2 Pate10 ENSMUST00000166746.2 prostate and testis expressed 10 (from RefSeq NM_001167588.2) B3GLJ5 B3GLJ5_MOUSE ENSMUST00000166746.1 Gm17677 NM_001167588 Pate10 uc012gqn.1 uc012gqn.2 uc012gqn.1 uc012gqn.2 
ENSMUST00000166750.9 Cmip ENSMUST00000166750.9 c-Maf inducing protein, transcript variant 1 (from RefSeq NM_001163262.1) CMIP_MOUSE ENSMUST00000166750.1 ENSMUST00000166750.2 ENSMUST00000166750.3 ENSMUST00000166750.4 ENSMUST00000166750.5 ENSMUST00000166750.6 ENSMUST00000166750.7 ENSMUST00000166750.8 Kiaa1694 NM_001163262 Q69ZD2 Q8C3N2 Q8K148 Q9D486 uc012gln.1 uc012gln.2 uc012gln.3 uc012gln.4 Plays a role in T-cell signaling pathway. Interacts with FLNA. Nucleus Cytoplasm Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS). Detected in nuclear and cytoplasmic compartments during MCNS relapse. Expressed in cytoplasm only during MCNS remission and absent in normal patients. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D486-1; Sequence=Displayed; Name=2; IsoId=Q9D486-2; Sequence=VSP_031113; Name=3; IsoId=Q9D486-3; Sequence=VSP_031114; Sequence=BAD32512.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; in utero embryonic development molecular_function nucleus nucleoplasm cytoplasm cytosol uc012gln.1 uc012gln.2 uc012gln.3 uc012gln.4 
ENSMUST00000166768.3 Spata2l ENSMUST00000166768.3 spermatogenesis associated 2-like, transcript variant 2 (from RefSeq NM_001357300.1) ENSMUST00000166768.1 ENSMUST00000166768.2 Kiaa4138 NM_001357300 Q3UTL5 Q5DTL7 Q8BNN1 SPA2L_MOUSE Spata2l uc009nup.1 uc009nup.2 uc009nup.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BNN1-1; Sequence=Displayed; Name=2; IsoId=Q8BNN1-2; Sequence=VSP_027334, VSP_027335; Belongs to the SPATA2 family. Sequence=BAD90513.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc009nup.1 uc009nup.2 uc009nup.3 
ENSMUST00000166772.9 Vrtn ENSMUST00000166772.9 vertebrae development associated, transcript variant 2 (from RefSeq NM_001168589.2) ENSMUST00000166772.1 ENSMUST00000166772.2 ENSMUST00000166772.3 ENSMUST00000166772.4 ENSMUST00000166772.5 ENSMUST00000166772.6 ENSMUST00000166772.7 ENSMUST00000166772.8 NM_001168589 Q3SYK4 VRTN_MOUSE uc011ypa.1 uc011ypa.2 Belongs to the vertnin family. negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding cellular_component uc011ypa.1 uc011ypa.2 
ENSMUST00000166780.2 Gm17099 ENSMUST00000166780.2 Gm17099 (from geneSymbol) ENSMUST00000166780.1 uc292gup.1 uc292gup.2 uc292gup.1 uc292gup.2 
ENSMUST00000166783.3 Ablim3 ENSMUST00000166783.3 actin binding LIM protein family, member 3, transcript variant 3 (from RefSeq NM_001360868.1) ABLM3_MOUSE ENSMUST00000166783.1 ENSMUST00000166783.2 Kiaa0843 NM_001360868 Q52KR1 Q69ZX8 Q6PAI7 uc008fct.1 uc008fct.2 uc008fct.3 uc008fct.4 uc008fct.5 uc008fct.6 May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. Directly interacts with F-actin and ABRA. Cytoplasm Expressed in heart, brain, lung and liver. In the brain, highly expressed in the olfactory bulb. In the hippocampus, expressed selectively in the CA2 and CA3 fields. In the cerebellum, expressed in internal granular cells. At 15.5 dpc, expressed in skeletal muscle. Down- regulated in adult skeletal muscle. Sequence=BAD32318.1; Type=Erroneous initiation; Evidence=; stress fiber actin binding cytoplasm transcription, DNA-templated cytoskeleton organization actin cytoskeleton lamellipodium lamellipodium assembly actin cytoskeleton organization synapse positive regulation of transcription from RNA polymerase II promoter metal ion binding actin filament binding cilium assembly glutamatergic synapse uc008fct.1 uc008fct.2 uc008fct.3 uc008fct.4 uc008fct.5 uc008fct.6 
ENSMUST00000166791.8 Cd2bp2 ENSMUST00000166791.8 CD2 cytoplasmic tail binding protein 2, transcript variant 4 (from RefSeq NM_027353.4) CD2B2_MOUSE ENSMUST00000166791.1 ENSMUST00000166791.2 ENSMUST00000166791.3 ENSMUST00000166791.4 ENSMUST00000166791.5 ENSMUST00000166791.6 ENSMUST00000166791.7 NM_027353 Q3TJX5 Q9CWK3 uc009jul.1 uc009jul.2 uc009jul.3 uc009jul.4 Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. Component of the U5 snRNP complex composed of the U5 snRNA and at least PRPF6, PRPF8, SNRNP200, EFTUD2, SNRNP40, DDX23, TXNL4A and CD2BP2. Interacts directly with TXNL4A and PRPF6. Interacts (via GYF domain) with CD2 (via Pro-rich sequence in the cytoplasmic domain). Interacts with PQBP1 (By similarity). Cytoplasm Nucleus Note=Predominantly nuclear. fibrillar center nucleus nucleoplasm U5 snRNP cytoplasm cytosol mRNA processing RNA splicing negative regulation of phosphatase activity nuclear speck ribonucleoprotein complex binding uc009jul.1 uc009jul.2 uc009jul.3 uc009jul.4 
ENSMUST00000166793.10 Matr3 ENSMUST00000166793.10 matrin 3, transcript variant 1 (from RefSeq NM_010771.7) ENSMUST00000166793.1 ENSMUST00000166793.2 ENSMUST00000166793.3 ENSMUST00000166793.4 ENSMUST00000166793.5 ENSMUST00000166793.6 ENSMUST00000166793.7 ENSMUST00000166793.8 ENSMUST00000166793.9 MATR3_MOUSE NM_010771 Q8K310 uc008emg.1 uc008emg.2 uc008emg.3 uc008emg.4 May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. May bind to specific miRNA hairpins. Part of a complex consisting of SFPQ, NONO and MATR3. Interacts with AGO1 and AGO2 (By similarity). Part of a complex composed at least of ASH2L, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3- specific methyltransferase activity. Interacts with TARDBP. Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA. Interacts with FUS. Interacts with IGF2BP1. Interacts with IGF2BP2 and IGF2BP3. Nucleus matrix blastocyst formation activation of innate immune response immune system process heart valve development ventricular septum development nucleic acid binding RNA binding nucleus cytoplasm zinc ion binding posttranscriptional regulation of gene expression nuclear matrix miRNA binding identical protein binding innate immune response metal ion binding uc008emg.1 uc008emg.2 uc008emg.3 uc008emg.4 
ENSMUST00000166808.3 Gm20538 ENSMUST00000166808.3 Belongs to the WD repeat SEC31 family. (from UniProt F6Z9R1) AK013516 ENSMUST00000166808.1 ENSMUST00000166808.2 F6Z9R1 F6Z9R1_MOUSE Gm20538 uc289sdb.1 uc289sdb.2 uc289sdb.3 Belongs to the WD repeat SEC31 family. Golgi membrane NADH dehydrogenase activity structural molecule activity mitochondrion intracellular protein transport ER to Golgi vesicle-mediated transport endoplasmic reticulum organization NADH dehydrogenase (ubiquinone) activity membrane integral component of membrane COPII vesicle coat oxidation-reduction process endoplasmic reticulum exit site cargo loading into COPII-coated vesicle COPII-coated vesicle budding uc289sdb.1 uc289sdb.2 uc289sdb.3 
ENSMUST00000166820.8 R3hdm2 ENSMUST00000166820.8 Nucleus (from UniProt Q80TM6) AK122416 ENSMUST00000166820.1 ENSMUST00000166820.2 ENSMUST00000166820.3 ENSMUST00000166820.4 ENSMUST00000166820.5 ENSMUST00000166820.6 ENSMUST00000166820.7 Kiaa1002 Q80TM6 Q80YB1 Q8BLS5 Q9CW50 R3HD2_MOUSE uc007hjk.1 uc007hjk.2 uc007hjk.3 uc007hjk.4 Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80TM6-1; Sequence=Displayed; Name=2; IsoId=Q80TM6-2; Sequence=VSP_010553, VSP_010554; Name=3; IsoId=Q80TM6-3; Sequence=VSP_010553; Name=4; IsoId=Q80TM6-4; Sequence=VSP_010555, VSP_010556; Sequence=AK043545; Type=Frameshift; Evidence=; Sequence=BAB23642.2; Type=Erroneous initiation; Evidence=; Sequence=BAC65698.1; Type=Erroneous initiation; Evidence=; nucleic acid binding cellular_component nucleus biological_process uc007hjk.1 uc007hjk.2 uc007hjk.3 uc007hjk.4 
ENSMUST00000166825.8 Naalad2 ENSMUST00000166825.8 N-acetylated alpha-linked acidic dipeptidase 2, transcript variant 3 (from RefSeq NM_028279.4) ENSMUST00000166825.1 ENSMUST00000166825.2 ENSMUST00000166825.3 ENSMUST00000166825.4 ENSMUST00000166825.5 ENSMUST00000166825.6 ENSMUST00000166825.7 NALD2_MOUSE NM_028279 Q80YF8 Q9CZR2 uc009ogo.1 uc009ogo.2 uc009ogo.3 Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate. Reaction=Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.; EC=3.4.17.21; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. Required for NAALADase activity. ; Homodimer. Cell membrane ; Single-pass type II membrane protein Expressed ovary, testes and lung, but not brain. The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal. Belongs to the peptidase M28 family. M28B subfamily. catalytic activity carboxypeptidase activity plasma membrane proteolysis metabolic process peptidase activity metallopeptidase activity membrane integral component of membrane hydrolase activity dipeptidase activity neurotransmitter catabolic process metal ion binding N-formylglutamate deformylase activity uc009ogo.1 uc009ogo.2 uc009ogo.3 
ENSMUST00000166847.8 Rsph10b ENSMUST00000166847.8 May function as part of the axonemal radial spoke complex 3 (RS3) (Probable). Radial spoke complexes are important for ciliary motility (PubMed:34871179). (from UniProt E9PYQ0) AK015903 E9PYQ0 ENSMUST00000166847.1 ENSMUST00000166847.2 ENSMUST00000166847.3 ENSMUST00000166847.4 ENSMUST00000166847.5 ENSMUST00000166847.6 ENSMUST00000166847.7 RS10B_MOUSE Rsph10b Rsph10b2 uc291bot.1 uc291bot.2 May function as part of the axonemal radial spoke complex 3 (RS3) (Probable). Radial spoke complexes are important for ciliary motility (PubMed:34871179). Interacts with RSPH6A (PubMed:30185526). Does not appear to be part of the axonemal radial spoke complexes 1 or 2 (PubMed:34871179). Cytoplasm, cytoskeleton, cilium axoneme Expressed in ependymal cells (at protein level). molecular_function cellular_component biological_process uc291bot.1 uc291bot.2 
ENSMUST00000166855.3 Mchr1 ENSMUST00000166855.3 melanin-concentrating hormone receptor 1 (from RefSeq NM_145132.2) ENSMUST00000166855.1 ENSMUST00000166855.2 Gpr24 MCHR1_MOUSE Mchr1 NM_145132 Q3UY93 Q8JZL2 Q8K3M8 Slc1 uc007wwh.1 uc007wwh.2 uc007wwh.3 Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. Interacts with NCDN. Q8JZL2; D3Z1Q2: Mrap2; NbExp=4; IntAct=EBI-44454520, EBI-44454554; Cell membrane ; Multi-pass membrane protein Event=Alternative promoter usage; Named isoforms=2; Name=1; IsoId=Q8JZL2-1; Sequence=Displayed; Name=2; IsoId=Q8JZL2-2; Sequence=VSP_059222; Expressed predominantly in the brain. Expression in brain is negatively regulated by leptin. Also found in the epithelium of the tongue and kidney. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity receptor binding plasma membrane integral component of plasma membrane cilium signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway protein C-terminus binding membrane integral component of membrane melanin-concentrating hormone receptor activity peptide binding hormone binding neuropeptide binding positive regulation of calcium ion transport ciliary membrane regulation of feeding behavior non-motile cilium uc007wwh.1 uc007wwh.2 uc007wwh.3 
ENSMUST00000166873.9 Cdh10 ENSMUST00000166873.9 cadherin 10, transcript variant 2 (from RefSeq NM_001316758.1) CAD10_MOUSE ENSMUST00000166873.1 ENSMUST00000166873.2 ENSMUST00000166873.3 ENSMUST00000166873.4 ENSMUST00000166873.5 ENSMUST00000166873.6 ENSMUST00000166873.7 ENSMUST00000166873.8 NM_001316758 P70408 Q3UUB3 Q80WS7 uc007vik.1 uc007vik.2 uc007vik.3 This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is expressed in the blood-brain barrier and retinal endothelia suggesting a role in the development and maintenance of brain barrier. Alternative splicing results in multiple transcript variants. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Oct 2015]. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cell membrane ; Single-pass type I membrane protein Expressed at all stages of testicular development with highest levels found in fetal gonad. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. cell morphogenesis calcium ion binding plasma membrane cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cytoskeletal protein binding cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex adherens junction organization protein homodimerization activity cell-cell adhesion mediated by cadherin cadherin binding metal ion binding cell-cell adhesion glutamatergic synapse GABA-ergic synapse integral component of presynaptic active zone membrane integral component of postsynaptic specialization membrane uc007vik.1 uc007vik.2 uc007vik.3 
ENSMUST00000166895.8 Gm3642 ENSMUST00000166895.8 Gm3642 (from geneSymbol) BC071263 ENSMUST00000166895.1 ENSMUST00000166895.2 ENSMUST00000166895.3 ENSMUST00000166895.4 ENSMUST00000166895.5 ENSMUST00000166895.6 ENSMUST00000166895.7 Gm3642 K7N6V4 K7N6V4_MOUSE uc288qpj.1 uc288qpj.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qpj.1 uc288qpj.2 
ENSMUST00000166897.3 Tomm70a ENSMUST00000166897.3 translocase of outer mitochondrial membrane 70A (from RefSeq NM_138599.5) D16Wsu109e ENSMUST00000166897.1 ENSMUST00000166897.2 NM_138599 Q8BNI6 Q9CZW5 TOM70_MOUSE Tomm70 uc007zmz.1 uc007zmz.2 uc007zmz.3 Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (By similarity). Mediates TBK1 and IRF3 activation induced by MAVS in response to virus infection and promotes host antiviral responses during virus infection (PubMed:20628368). Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70) (By similarity). Interacts with CAPN8 (PubMed:16476741). Interacts with TRADD, TRAF6 and STING. Interacts with MAVS. Interacts with HSPA8 and HSP90AA1; both interactions are required for preprotein mitochondrial import. The interaction with HSP90AA1 is direct and mediates the association of TOMM70 with IRF3 and TBK1 (By similarity). Q9CZW5; Q8K443: Rgs13; NbExp=12; IntAct=EBI-642469, EBI-645999; Mitochondrion outer membrane ; Single-pass membrane protein Expressed in the base region of the oxyntic and pyloric mucosae. Belongs to the Tom70 family. protein binding mitochondrion mitochondrial outer membrane mitochondrial outer membrane translocase complex protein targeting to mitochondrion membrane integral component of membrane integral component of mitochondrial outer membrane negative regulation of cell growth involved in cardiac muscle cell development positive regulation of protein import uc007zmz.1 uc007zmz.2 uc007zmz.3 
ENSMUST00000166912.3 Phf11c ENSMUST00000166912.3 PHD finger protein 11C (from RefSeq NM_001164289.1) B4XVP9 B4XVP9_MOUSE EG628705 ENSMUST00000166912.1 ENSMUST00000166912.2 Gm6907 NM_001164289 Phf11-1 Phf11c uc011zmn.1 uc011zmn.2 uc011zmn.3 Nucleus molecular_function nucleoplasm biological_process nuclear membrane metal ion binding uc011zmn.1 uc011zmn.2 uc011zmn.3 
ENSMUST00000166915.8 Snrpe ENSMUST00000166915.8 small nuclear ribonucleoprotein E (from RefSeq NM_009227.3) ENSMUST00000166915.1 ENSMUST00000166915.2 ENSMUST00000166915.3 ENSMUST00000166915.4 ENSMUST00000166915.5 ENSMUST00000166915.6 ENSMUST00000166915.7 NM_009227 P08578 P62305 Q15498 RUXE_MOUSE uc007cql.1 uc007cql.2 uc007cql.3 uc007cql.4 Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing. Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with SMN1; the interaction is direct. Interacts with GEMIN2 (via N-terminus); the interaction is direct. Interacts with SNRPF; the interaction is direct. Interacts with SNRPG; the interaction is direct. Cytoplasm, cytosol Nucleus Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. Belongs to the snRNP Sm proteins family. spliceosomal snRNP assembly mRNA splicing, via spliceosome RNA binding nucleus spliceosomal complex U5 snRNP U7 snRNP U1 snRNP U2 snRNP U4 snRNP cytoplasm cytosol mRNA processing RNA splicing methylosome pICln-Sm protein complex SMN-Sm protein complex hair cycle U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome U1 snRNP binding uc007cql.1 uc007cql.2 uc007cql.3 uc007cql.4 
ENSMUST00000166917.3 Oxr1 ENSMUST00000166917.3 oxidation resistance 1, transcript variant 3 (from RefSeq NM_001130164.1) B1H3M0 B1H3M0_MOUSE ENSMUST00000166917.1 ENSMUST00000166917.2 NM_001130164 Oxr1 uc011zso.1 uc011zso.2 uc011zso.3 uc011zso.4 uc011zso.1 uc011zso.2 uc011zso.3 uc011zso.4 
ENSMUST00000166919.4 Cabcoco1 ENSMUST00000166919.4 Calcium-binding protein (PubMed:26990073). May be involved in the control of sperm flagellar movement (PubMed:26990073). (from UniProt Q8CDT7) BC087900 CBCO1_MOUSE Cabcoco1 ENSMUST00000166919.1 ENSMUST00000166919.2 ENSMUST00000166919.3 Q8CDT7 uc287rww.1 uc287rww.2 Calcium-binding protein (PubMed:26990073). May be involved in the control of sperm flagellar movement (PubMed:26990073). Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cell projection, cilium, flagellum Note=Colocalized with pericentrin at centrosome of spermatocytes and round spermatids (PubMed:26990073). Testis-specific (PubMed:26990073). Expressed in spermatocytes and round spermatids (at protein level) (PubMed:26990073). Sequence=AAH87900.1; Type=Erroneous initiation; Evidence=; Sequence=BAC26533.1; Type=Erroneous initiation; Evidence=; calcium ion binding cytoplasm centrosome microtubule organizing center cytoskeleton cilium biological_process motile cilium sperm flagellum cell projection metal ion binding uc287rww.1 uc287rww.2 
ENSMUST00000166937.2 Vmn1r117 ENSMUST00000166937.2 vomeronasal 1 receptor 117 (from RefSeq NM_001166743.1) ENSMUST00000166937.1 L7N2C9 L7N2C9_MOUSE NM_001166743 Vmn1r117 uc012fcr.1 uc012fcr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fcr.1 uc012fcr.2 
ENSMUST00000166948.2 Vmn1r123 ENSMUST00000166948.2 vomeronasal 1 receptor 123 (from RefSeq NM_001166707.1) ENSMUST00000166948.1 L7N270 L7N270_MOUSE NM_001166707 Vmn1r123 uc012fcx.1 uc012fcx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fcx.1 uc012fcx.2 
ENSMUST00000166956.2 Skor2 ENSMUST00000166956.2 SKI family transcriptional corepressor 2 (from RefSeq NM_001109743.1) A7M7C7 Corl2 ENSMUST00000166956.1 NM_001109743 SKOR2_MOUSE Skor2 uc008fqq.1 uc008fqq.2 Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity. Interacts with SMAD2 and SMAD3. Nucleus Cytoplasm Expression is restricted to adult and embryonic central nervous system. Expressed at high levels in the developing cerebellum, ventral metencephalon and myelencephalon at 12.5 dpc (at protein level). In the adult cerebellum, expressed specifically in Purkinje cells. First detected at 11 dpc and expression continues into adulthood with higher levels in embryonic than adult brain. In developing brain, not expressed in neural progenitors during the proliferative phase but expression is detected in postmitotic neural precursors shortly after exiting the cell cycle. Belongs to the SKI family. negative regulation of transcription from RNA polymerase II promoter chromatin binding transcription corepressor activity nucleus cytoplasm cerebellum morphogenesis cerebellar Purkinje cell differentiation regulation of cerebellar granule cell precursor proliferation negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway histone deacetylase binding negative regulation of cell differentiation positive regulation of smoothened signaling pathway SMAD binding cell development regulation of dendrite morphogenesis uc008fqq.1 uc008fqq.2 
ENSMUST00000166968.9 Nrg3 ENSMUST00000166968.9 neuregulin 3, transcript variant 1 (from RefSeq NM_008734.3) ENSMUST00000166968.1 ENSMUST00000166968.2 ENSMUST00000166968.3 ENSMUST00000166968.4 ENSMUST00000166968.5 ENSMUST00000166968.6 ENSMUST00000166968.7 ENSMUST00000166968.8 NM_008734 NRG3_MOUSE O35181 uc007tbz.1 uc007tbz.2 uc007tbz.3 uc007tbz.4 Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. Interacts with ERBB4. [Pro-neuregulin-3, membrane-bound isoform]: Cell membrane ; Single-pass type I membrane protein Note=Does not seem to be active. [Neuregulin-3]: Secreted Expressed in sympathetic, motor, and sensory neurons. Detected as early as 11 dpc. At 13 dpc detected mainly in the nervous system. At 16 dpc, detected in the brain, spinal cord, trigeminal, vestibular-cochlear, and spinal ganglia. In adults, expressed in spinal cord, and numerous brain regions. The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity). ERBB receptor binding is elicited entirely by the EGF-like domain. Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. Belongs to the neuregulin family. receptor binding protein binding extracellular region extracellular space plasma membrane pattern specification process nervous system development growth factor activity membrane integral component of membrane chemorepulsion involved in interneuron migration from the subpallium to the cortex mammary gland development intracellular signal transduction chemorepellent activity modulation of synaptic transmission mammary placode formation glutamatergic synapse negative regulation of neuron migration uc007tbz.1 uc007tbz.2 uc007tbz.3 uc007tbz.4 
ENSMUST00000166984.8 Fubp1 ENSMUST00000166984.8 far upstream element (FUSE) binding protein 1, transcript variant 11 (from RefSeq NR_149713.1) ENSMUST00000166984.1 ENSMUST00000166984.2 ENSMUST00000166984.3 ENSMUST00000166984.4 ENSMUST00000166984.5 ENSMUST00000166984.6 ENSMUST00000166984.7 Fubp1 NR_149713 Q3TUE1 Q3TUE1_MOUSE uc008rta.1 uc008rta.2 uc008rta.3 nucleic acid binding RNA binding nucleus nucleoplasm regulation of transcription, DNA-templated positive regulation of gene expression uc008rta.1 uc008rta.2 uc008rta.3 
ENSMUST00000167004.3 Gpat4 ENSMUST00000167004.3 glycerol-3-phosphate acyltransferase 4 (from RefSeq NM_018743.4) Agpat6 ENSMUST00000167004.1 ENSMUST00000167004.2 GPAT4_MOUSE Gpat4 NM_018743 Q3TF78 Q5QHR4 Q8K2C8 Tsarg7 uc009leo.1 uc009leo.2 uc009leo.3 uc009leo.4 Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:18238778). Active against both saturated and unsaturated long-chain fatty acyl- CoAs (By similarity). Protects cells against lipotoxicity (By similarity). Reaction=an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3- phosphate + CoA; Xref=Rhea:RHEA:15325, ChEBI:CHEBI:57287, ChEBI:CHEBI:57597, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342; EC=2.3.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15326; Evidence=; Reaction=dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn- glycerol 3-phosphate + CoA; Xref=Rhea:RHEA:35727, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:57597, ChEBI:CHEBI:72682; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35728; Evidence=; Reaction=hexadecanoyl-CoA + sn-glycerol 3-phosphate = 1-hexadecanoyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:35723, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57518, ChEBI:CHEBI:57597; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35724; Evidence=; Reaction=octadecanoyl-CoA + sn-glycerol 3-phosphate = 1-octadecanoyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37195, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57597, ChEBI:CHEBI:74565; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37196; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z- octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37199, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57597, ChEBI:CHEBI:74544; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37200; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1- (9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37203, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:57597, ChEBI:CHEBI:74547; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37204; Evidence=; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 1/3. Endoplasmic reticulum membrane ; Multi-pass membrane protein Highly expressed in testis. The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. glandular epithelial cell maturation glycerol-3-phosphate O-acyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process triglyceride metabolic process phosphatidylcholine biosynthetic process lactation lipid biosynthetic process phospholipid biosynthetic process membrane integral component of membrane CDP-diacylglycerol biosynthetic process transferase activity transferase activity, transferring acyl groups triglyceride biosynthetic process integral component of endoplasmic reticulum membrane mammary gland development regulation of multicellular organism growth diacylglycerol metabolic process uc009leo.1 uc009leo.2 uc009leo.3 uc009leo.4 
ENSMUST00000167023.8 Dus1l ENSMUST00000167023.8 dihydrouridine synthase 1 like, transcript variant 9 (from RefSeq NR_184655.1) DUS1L_MOUSE ENSMUST00000167023.1 ENSMUST00000167023.2 ENSMUST00000167023.3 ENSMUST00000167023.4 ENSMUST00000167023.5 ENSMUST00000167023.6 ENSMUST00000167023.7 NR_184655 Q8C2P3 Q8VCN7 Q9D124 uc007mus.1 uc007mus.2 Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Reaction=5,6-dihydrouridine(16) in tRNA + NADP(+) = H(+) + NADPH + uridine(16) in tRNA; Xref=Rhea:RHEA:53376, Rhea:RHEA-COMP:13543, Rhea:RHEA-COMP:13544, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:65315, ChEBI:CHEBI:74443; EC=1.3.1.88; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:53378; Evidence=; Reaction=5,6-dihydrouridine(16) in tRNA + NAD(+) = H(+) + NADH + uridine(16) in tRNA; Xref=Rhea:RHEA:53380, Rhea:RHEA-COMP:13543, Rhea:RHEA-COMP:13544, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:65315, ChEBI:CHEBI:74443; EC=1.3.1.88; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:53382; Evidence=; Reaction=5,6-dihydrouridine(17) in tRNA + NAD(+) = H(+) + NADH + uridine(17) in tRNA; Xref=Rhea:RHEA:53372, Rhea:RHEA-COMP:13541, Rhea:RHEA-COMP:13542, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:65315, ChEBI:CHEBI:74443; EC=1.3.1.88; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:53374; Evidence=; Reaction=5,6-dihydrouridine(17) in tRNA + NADP(+) = H(+) + NADPH + uridine(17) in tRNA; Xref=Rhea:RHEA:53368, Rhea:RHEA-COMP:13541, Rhea:RHEA-COMP:13542, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:65315, ChEBI:CHEBI:74443; EC=1.3.1.88; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:53370; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Belongs to the Dus family. Dus1 subfamily. Sequence=AAH19480.1; Type=Erroneous initiation; Evidence=; Sequence=BAB23138.1; Type=Erroneous initiation; Evidence=; tRNA dihydrouridine synthesis catalytic activity tRNA processing oxidoreductase activity tRNA dihydrouridine synthase activity flavin adenine dinucleotide binding oxidation-reduction process uc007mus.1 uc007mus.2 
ENSMUST00000167041.9 Speer1f ENSMUST00000167041.9 Speer1f (from geneSymbol) ENSMUST00000167041.1 ENSMUST00000167041.2 ENSMUST00000167041.3 ENSMUST00000167041.4 ENSMUST00000167041.5 ENSMUST00000167041.6 ENSMUST00000167041.7 ENSMUST00000167041.8 Gm8897 L7N294 L7N294_MOUSE uc290tdn.1 uc290tdn.2 uc290tdn.3 uc290tdn.1 uc290tdn.2 uc290tdn.3 
ENSMUST00000167042.8 Gm49396 ENSMUST00000167042.8 RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. It can functionally substitute for U2AF1 in constitutive splicing and enhancer-dependent splicing. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Shows a preference for AGC or AGA (PubMed:11739736, PubMed:16819553, PubMed:18460468). Alternative splicing of U2AF1L4 may play a role in connecting the circadian rhythm to changing external cues: may provide a circadian buffering system in central and periphery clocks that allows synchronized adaption to clock-resetting stimuli in order to prevent potentially pathogenic desynchronization (PubMed:24837677). (from UniProt Q8BGJ9) AK160974 ENSMUST00000167042.1 ENSMUST00000167042.2 ENSMUST00000167042.3 ENSMUST00000167042.4 ENSMUST00000167042.5 ENSMUST00000167042.6 ENSMUST00000167042.7 Q8BGJ9 U2AF4_MOUSE U2af1l4 U2af26 uc291nyb.1 uc291nyb.2 RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. It can functionally substitute for U2AF1 in constitutive splicing and enhancer-dependent splicing. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Shows a preference for AGC or AGA (PubMed:11739736, PubMed:16819553, PubMed:18460468). Alternative splicing of U2AF1L4 may play a role in connecting the circadian rhythm to changing external cues: may provide a circadian buffering system in central and periphery clocks that allows synchronized adaption to clock-resetting stimuli in order to prevent potentially pathogenic desynchronization (PubMed:24837677). Interacts with GFI1, U2AF2 and C1QBP. Isoform 3 interacts with PER1. Q8BGJ9; O35658: C1qbp; NbExp=4; IntAct=EBI-4288480, EBI-642072; Q8BGJ9; P70338: Gfi1; NbExp=5; IntAct=EBI-4288480, EBI-3954754; [Isoform 1]: Nucleus Nucleus speckle Cytoplasm te=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo-cytoplasmic shuttling. [Isoform 3]: Cytoplasm [Isoform 2]: Cytoplasm Event=Alternative splicing; Named isoforms=4; Comment=Circadian and light-inducible alternative splicing, which occurs at least in brain and liver.; Name=1; Synonyms=fl ; IsoId=Q8BGJ9-1; Sequence=Displayed; Name=2; Synonyms=U2AF26DeltaE7, DE7 IsoId=Q8BGJ9-2; Sequence=VSP_056877; Name=3; Synonyms=U2AF26DeltaE67, DE67 IsoId=Q8BGJ9-3; Sequence=VSP_056875; Name=4; IsoId=Q8BGJ9-4; Sequence=VSP_056874, VSP_056876; Ubiquitous. Highly expressed in the brain. Up-regulated in response to T-cell activation (at protein level) (PubMed:16819553). Circadian alternative splicing switch accounts for rhythmic isoform expression. A circadian splicing switch produces isoform 3 in the brain cerebellum and liver (at protein level). Isoform 3 expression is regulated with the circadian rhythm but is also quickly increased upon light exposure (4-8 hours after light exposure). Expression of isoform 3 changes approximately 5-fold across a period of 24 hours, with concomitant changes in isoform 1, resulting in total U2af1l4 remaining constant (PubMed:24837677). The second zinc finger in necessary for interaction with GFI1 and for alternative pre-mRNA splicing events. The region 162-220 is essential for the nuclear import of the protein in spite of the absence of a nuclear localization signal (NLS). This region is essential for the interaction with C1QBP, interaction which is required for the nuclear translocation. This region may be involved in the localization in nuclear dot-like structures and it also confers the ability of nucleo-cytoplasmic shuttling. Isoform 3 contains a C-terminus domain with homology to Drosophila TIM (THD domain). Isoform 3 interacts with Per1 and specifically down-regulates its expression, probably by facilitating its recruitment to the proteasome. The interaction with PER1 depends on the presence of the THD domain, but the THD domain is not directly involved in the interaction. Isoform 3 is rapidly degraded by a proteasome-mediated degradation pathway. Mutant mice show defects in circadian gene expression and jet lag phenotype, but the master clock is not strongly affected. Per2 expression is rhythmic, but Per1 expression becomes nearly arrhythmic as well as Per1 target genes, such as Dbp. No splicing alteration was observed in the brain. Mutant mice show a faster adaptation to experimental jet lag, which is consistent with the circadian splicing switch providing a buffering system against sudden light changes. [Isoform 1]: Cytoplasmic and nuclear. Displays active nucleo-cytoplasmic shuttling. Shows a circadian expression at the mRNA level. [Isoform 2]: Produced by exon 7 skipping. Cytoplasm (PubMed:16819553). Shows a circadian expression at the mRNA level. [Isoform 3]: Produced by exons 6 and 7 skipping. Produced by a circadian splicing switch in brain and liver. Contains a C-terminus domain with homology to Drosophila TIM (THD). Cytoplasmic. Shows a circadian expression at the mRNA and protein levels. Expression is quickly increased upon light exposure. Has a strongly reduced half- life compared to other isoforms. [Isoform 4]: Produced by usage of an alternative 3' splice site in exon 8. Belongs to the splicing factor SR family. Orthologs of U2af1l4 do not appear to exist in lower eukaryotes, Drosophila, C. elegans, plants, or vertebrates such as Xenopus or zebrafish (PubMed:11739736). Existence of splicing isoforms of U2af1l4 in human and rat is not yet proven. mRNA splicing, via spliceosome nucleic acid binding RNA binding protein binding nucleus spliceosomal complex cytoplasm mRNA processing RNA splicing nuclear speck pre-mRNA 3'-splice site binding metal ion binding rhythmic process U2AF uc291nyb.1 uc291nyb.2 
ENSMUST00000167049.8 Serpina3f ENSMUST00000167049.8 serine (or cysteine) peptidase inhibitor, clade A, member 3F, transcript variant 3 (from RefSeq NM_001168295.1) B2RT49 ENSMUST00000167049.1 ENSMUST00000167049.2 ENSMUST00000167049.3 ENSMUST00000167049.4 ENSMUST00000167049.5 ENSMUST00000167049.6 ENSMUST00000167049.7 NM_001168295 Q80X76 SPA3F_MOUSE uc007owx.1 uc007owx.2 uc007owx.3 The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity. The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 14 individual murine paralogs. Belongs to the serpin family. Sequence=AAH49975.1; Type=Erroneous initiation; Evidence=; serine-type endopeptidase inhibitor activity extracellular space response to bacterium negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to cytokine response to peptide hormone uc007owx.1 uc007owx.2 uc007owx.3 
ENSMUST00000167055.2 Carns1 ENSMUST00000167055.2 carnosine synthase 1, transcript variant 1 (from RefSeq NM_134148.3) Carns1 E9PX09 E9PX09_MOUSE ENSMUST00000167055.1 NM_134148 uc012bgf.1 uc012bgf.2 nucleotide binding ATP binding ATPase activity carnosine biosynthetic process metal ion binding carnosine synthase activity uc012bgf.1 uc012bgf.2 
ENSMUST00000167058.8 Mast4 ENSMUST00000167058.8 microtubule associated serine/threonine kinase family member 4 (from RefSeq NM_175171.3) E9QAH7 ENSMUST00000167058.1 ENSMUST00000167058.2 ENSMUST00000167058.3 ENSMUST00000167058.4 ENSMUST00000167058.5 ENSMUST00000167058.6 ENSMUST00000167058.7 MAST4_MOUSE Mast4 NM_175171 Q3UVE7 Q62489 Q6ZQE0 Q811L6 Q8BME3 uc007rsb.1 uc007rsb.2 uc007rsb.3 uc007rsb.4 uc007rsb.5 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1 IsoId=Q811L6-1; Sequence=Displayed; Name=2 ; IsoId=Q811L6-2; Sequence=VSP_041616, VSP_052478, VSP_052479, VSP_052480; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Sequence=AK090136; Type=Frameshift; Evidence=; nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm protein phosphorylation cytoskeleton organization kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction metal ion binding uc007rsb.1 uc007rsb.2 uc007rsb.3 uc007rsb.4 uc007rsb.5 
ENSMUST00000167093.3 Vmn2r109 ENSMUST00000167093.3 vomeronasal 2, receptor 109 (from RefSeq NM_001104571.1) ENSMUST00000167093.1 ENSMUST00000167093.2 K7N747 K7N747_MOUSE NM_001104571 Vmn2r109 uc009vbm.1 uc009vbm.2 uc009vbm.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vbm.1 uc009vbm.2 uc009vbm.3 
ENSMUST00000167107.10 Zfp101 ENSMUST00000167107.10 zinc finger protein 101, transcript variant 1 (from RefSeq NM_009542.3) ENSMUST00000167107.1 ENSMUST00000167107.2 ENSMUST00000167107.3 ENSMUST00000167107.4 ENSMUST00000167107.5 ENSMUST00000167107.6 ENSMUST00000167107.7 ENSMUST00000167107.8 ENSMUST00000167107.9 NM_009542 Q8BP18 Q8BP18_MOUSE Zfp101 uc008byk.1 uc008byk.2 uc008byk.3 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc008byk.1 uc008byk.2 uc008byk.3 
ENSMUST00000167113.8 Trim43b ENSMUST00000167113.8 tripartite motif-containing 43B (from RefSeq NM_001170884.1) ENSMUST00000167113.1 ENSMUST00000167113.2 ENSMUST00000167113.3 ENSMUST00000167113.4 ENSMUST00000167113.5 ENSMUST00000167113.6 ENSMUST00000167113.7 NM_001170884 P86448 TR43B_MOUSE Trim43b uc012gyc.1 uc012gyc.2 Expression is restricted to preimplantation embryos and peaks at the 8-cell to morula stage. Belongs to the TRIM/RBCC family. cellular_component biological_process zinc ion binding metal ion binding uc012gyc.1 uc012gyc.2 
ENSMUST00000167122.8 Adamts7 ENSMUST00000167122.8 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; (from UniProt E9PX36) AY551090 Adamts7 E9PX36 E9PX36_MOUSE ENSMUST00000167122.1 ENSMUST00000167122.2 ENSMUST00000167122.3 ENSMUST00000167122.4 ENSMUST00000167122.5 ENSMUST00000167122.6 ENSMUST00000167122.7 uc292jot.1 uc292jot.2 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted, extracellular space, extracellular matrix Lacks conserved residue(s) required for the propagation of feature annotation. metalloendopeptidase activity proteolysis metallopeptidase activity uc292jot.1 uc292jot.2 
ENSMUST00000167133.3 Vmn2r15 ENSMUST00000167133.3 vomeronasal 2, receptor 15 (from RefSeq NM_001104626.1) ENSMUST00000167133.1 ENSMUST00000167133.2 L7N2A0 L7N2A0_MOUSE NM_001104626 Vmn2r15 uc009vdm.1 uc009vdm.2 uc009vdm.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vdm.1 uc009vdm.2 uc009vdm.3 
ENSMUST00000167140.8 Mpst ENSMUST00000167140.8 mercaptopyruvate sulfurtransferase, transcript variant 7 (from RefSeq NM_001416060.1) ENSMUST00000167140.1 ENSMUST00000167140.2 ENSMUST00000167140.3 ENSMUST00000167140.4 ENSMUST00000167140.5 ENSMUST00000167140.6 ENSMUST00000167140.7 NM_001416060 Q3UW66 Q505N7 Q99J99 THTM_MOUSE uc011zvq.1 uc011zvq.2 uc011zvq.3 Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions. Reaction=2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate; Xref=Rhea:RHEA:21740, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:29919, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57678; EC=2.8.1.2; Evidence=; By oxidative stress, and thioredoxin. Under oxidative stress conditions, the catalytic cysteine site is converted to a sulfenate which inhibits the MPST enzyme activity. Reduced thioredoxin cleaves an intersubunit disulfide bond to turn on the redox switch and reactivate the enzyme. Inhibited by different oxidants, hydrogen peroxide and tetrathionate. Monomer (active form). Homodimer; disulfide-linked (inactive form). Cytoplasm Mitochondrion Synapse, synaptosome Expressed in the brain and retina. In the retina, localized to the inner and outer plexiform layer, the inner and outer nuclear layer and the outer segments of photoreceptors. In the brain, localized to neurons of mitral cell layers, glomerular, and external plexiform layers in the olfactory bulb. Also found in Purkinje cell stomata and proximal dendrites. In the spinal cord, localized to large neurons. In the cerebral cortex, localized to pyramidial neurons in layers II/III and V, and in layers I-VI of neocortical areas. In the hippocampus, found in CA1 and CA3 pyramidal cells. In the developing brain, maintained expression from 16 dpc to postnatal day 14. Levels decrease between postnatal day 28 and postnatal day 52 and increase again with further aging up to 156 days old. Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity). Thioredoxin (Trx) or dihydrolipoic acid (DHLA) are required to release hydrogen sulfide from the persulfide intermediate. kidney development liver development thiosulfate sulfurtransferase activity cytoplasm mitochondrion mitochondrial inner membrane cytosol transferase activity 3-mercaptopyruvate sulfurtransferase activity transsulfuration spinal cord development cell junction identical protein binding neuron projection synapse hydrogen sulfide biosynthetic process uc011zvq.1 uc011zvq.2 uc011zvq.3 
ENSMUST00000167143.2 Cd79b ENSMUST00000167143.2 CD79B antigen, transcript variant 1 (from RefSeq NM_008339.3) CD79B_MOUSE ENSMUST00000167143.1 Igb NM_008339 P15530 Q4FJP4 uc288czr.1 uc288czr.2 The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2015]. Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN. P15530; P15530: Cd79b; NbExp=3; IntAct=EBI-15869050, EBI-15869050; Cell membrane ingle-pass type I membrane protein Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. B-cells. The transmembrane helices of CD79A and CD79B chains and two IgM heavy chains assembly in a four-helix bundle structure that appears to be conserved among different BCR isotypes. Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr- kinases such as BLK, LYN and SYK. adaptive immune response immune system process transmembrane signaling receptor activity protein binding nucleoplasm Golgi apparatus cytosol plasma membrane cell surface receptor signaling pathway response to bacterium external side of plasma membrane membrane integral component of membrane B cell receptor complex B cell differentiation identical protein binding protein homodimerization activity B cell receptor signaling pathway protein homooligomerization uc288czr.1 uc288czr.2 
ENSMUST00000167175.8 Gm49387 ENSMUST00000167175.8 Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; (from UniProt E9Q9L4) BC021360 E9Q9L4 E9Q9L4_MOUSE ENSMUST00000167175.1 ENSMUST00000167175.2 ENSMUST00000167175.3 ENSMUST00000167175.4 ENSMUST00000167175.5 ENSMUST00000167175.6 ENSMUST00000167175.7 Gm49387 uc288sde.1 uc288sde.2 Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; thiamine pyrophosphate binding uc288sde.1 uc288sde.2 
ENSMUST00000167180.8 Oard1 ENSMUST00000167180.8 O-acyl-ADP-ribose deacylase 1, transcript variant 19 (from RefSeq NR_182173.1) ENSMUST00000167180.1 ENSMUST00000167180.2 ENSMUST00000167180.3 ENSMUST00000167180.4 ENSMUST00000167180.5 ENSMUST00000167180.6 ENSMUST00000167180.7 NR_182173 OARD1_MOUSE Oard1 Q3U5M3 Q8R5F3 uc008cxu.1 uc008cxu.2 uc008cxu.3 uc008cxu.4 ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP- ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively. Reaction=2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+); Xref=Rhea:RHEA:57060, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:83767; Evidence=; Reaction=5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = ADP-D-ribose + H(+) + L-glutamyl-[protein]; Xref=Rhea:RHEA:58248, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:57967, ChEBI:CHEBI:142540; Evidence=; Reaction=alpha-NAD(+) + H2O = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:68792, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57967, ChEBI:CHEBI:77017; Evidence=; Subject to competitive inhibition by the product ADP-ribose. Nucleus, nucleoplasm Nucleus, nucleolus Chromosome Note=Localizes both in the nucleoplasm and in the nucleolus. Relocalizes to the nucleoplasm in response to DNA damage. Recruited to DNA lesion regions following DNA damage. purine nucleoside binding nucleus nucleoplasm chromosome nucleolus cellular response to DNA damage stimulus hydrolase activity purine nucleoside metabolic process protein de-ADP-ribosylation O-acetyl-ADP-ribose deacetylase activity uc008cxu.1 uc008cxu.2 uc008cxu.3 uc008cxu.4 
ENSMUST00000167182.8 Hnrnpf ENSMUST00000167182.8 heterogeneous nuclear ribonucleoprotein F, transcript variant 7 (from RefSeq NM_001166432.1) ENSMUST00000167182.1 ENSMUST00000167182.2 ENSMUST00000167182.3 ENSMUST00000167182.4 ENSMUST00000167182.5 ENSMUST00000167182.6 ENSMUST00000167182.7 HNRPF_MOUSE Hnrpf NM_001166432 Q5FWK2 Q8BVU8 Q8K2U9 Q8R0E7 Q9Z2X1 uc012eqx.1 uc012eqx.2 uc012eqx.3 Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity). Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1 (By similarity). Nucleus, nucleoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z2X1-1; Sequence=Displayed; Name=2; IsoId=Q9Z2X1-2; Sequence=VSP_021004; The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA. Sumoylated. Sequence=AAH27003.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH29764.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC36361.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; nucleic acid binding RNA binding single-stranded RNA binding nucleus nucleoplasm spliceosomal complex cytosol mRNA processing transcription factor binding RNA splicing TBP-class protein binding regulation of RNA splicing catalytic step 2 spliceosome uc012eqx.1 uc012eqx.2 uc012eqx.3 
ENSMUST00000167199.3 Mrpl16 ENSMUST00000167199.3 mitochondrial ribosomal protein L16 (from RefSeq NM_025606.3) ENSMUST00000167199.1 ENSMUST00000167199.2 NM_025606 Q99N93 RM16_MOUSE uc008gsx.1 uc008gsx.2 uc008gsx.3 uc008gsx.4 uc008gsx.5 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the universal ribosomal protein uL16 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation rRNA binding mitochondrial translation uc008gsx.1 uc008gsx.2 uc008gsx.3 uc008gsx.4 uc008gsx.5 
ENSMUST00000167226.2 Gm17201 ENSMUST00000167226.2 Gm17201 (from geneSymbol) ENSMUST00000167226.1 uc287vsu.1 uc287vsu.2 uc287vsu.1 uc287vsu.2 
ENSMUST00000167231.3 Gm17079 ENSMUST00000167231.3 Gm17079 (from geneSymbol) ENSMUST00000167231.1 ENSMUST00000167231.2 F7D8Y4 F7D8Y4_MOUSE Gm17079 uc288tpx.1 uc288tpx.2 uc288tpx.1 uc288tpx.2 
ENSMUST00000167245.8 Gm3159 ENSMUST00000167245.8 Gm3159 (from geneSymbol) ENSMUST00000167245.1 ENSMUST00000167245.2 ENSMUST00000167245.3 ENSMUST00000167245.4 ENSMUST00000167245.5 ENSMUST00000167245.6 ENSMUST00000167245.7 Gm3159 K7N760 K7N760_MOUSE uc288qjo.1 uc288qjo.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qjo.1 uc288qjo.2 
ENSMUST00000167253.2 Vmn1r252 ENSMUST00000167253.2 vomeronasal 1 receptor 252 (from RefSeq NM_001167150.1) ENSMUST00000167253.1 Gm4498 Gm8453 K9J7G4 K9J7G4_MOUSE NM_001167150 Vmn1r242 Vmn1r252 uc012fdv.1 uc012fdv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fdv.1 uc012fdv.2 
ENSMUST00000167256.8 Taf9 ENSMUST00000167256.8 TATA-box binding protein associated factor 9, transcript variant 3 (from RefSeq NM_001015889.2) ENSMUST00000167256.1 ENSMUST00000167256.2 ENSMUST00000167256.3 ENSMUST00000167256.4 ENSMUST00000167256.5 ENSMUST00000167256.6 ENSMUST00000167256.7 NM_001015889 Q32P09 Q80XS3 Q8VI33 Q9CV61 TAF9_MOUSE Taf2g uc007rrh.1 uc007rrh.2 uc007rrh.3 The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. Essential for cell viability. May have a role in gene regulation associated with apoptosis. Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP- associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. The PCAF complex consists at least of TADA2L/ADA2, SUPT3H/SPT3, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. The STAGA transcription coactivator-HAT complex consists at least of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Binds N- terminal domain of p53/TP53 which is essential for transcription. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Binds TFIIB and the Herpes simplex virus activator VP16. Forms a heterodimer with TAF6 in a complex with the TAF4B-TAF12 heterodimer. Also interacts with TAF5. Binds directly DNA. Increased DNA binding when complexed with TAF6. Nucleus Belongs to the TAF9 family. AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species. Sequence=BAB26216.2; Type=Erroneous initiation; Evidence=; SAGA complex PCAF complex box C/D snoRNP assembly p53 binding DNA binding transcription coactivator activity nucleus transcription factor TFIID complex DNA-templated transcription, initiation transcription from RNA polymerase II promoter transcription factor binding positive regulation of cell growth STAGA complex negative regulation of proteasomal ubiquitin-dependent protein catabolic process transcription factor TFTC complex activating transcription factor binding negative regulation of apoptotic process histone H3 acetylation transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity protein stabilization ATPase binding positive regulation of response to cytokine stimulus response to interleukin-1 C2H2 zinc finger domain binding pre-snoRNP complex MLL1 complex histone acetyltransferase activity uc007rrh.1 uc007rrh.2 uc007rrh.3 
ENSMUST00000167258.8 Ttll6 ENSMUST00000167258.8 tubulin tyrosine ligase-like family, member 6 (from RefSeq NM_172799.4) A2A6M6 A4Q9E8 B2RQS4 ENSMUST00000167258.1 ENSMUST00000167258.2 ENSMUST00000167258.3 ENSMUST00000167258.4 ENSMUST00000167258.5 ENSMUST00000167258.6 ENSMUST00000167258.7 NM_172799 Q3UL10 Q8BVQ1 TTLL6_MOUSE Ttll6 uc011ydd.1 uc011ydd.2 uc011ydd.3 Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins (PubMed:17499049, PubMed:21074048, PubMed:20530212, PubMed:26829768, PubMed:32747782). Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction (PubMed:17499049, PubMed:21074048, PubMed:20530212, PubMed:26829768, PubMed:32747782). Preferentially modifies the alpha-tubulin tail over a beta-tail (PubMed:17499049, PubMed:20530212, PubMed:21074048, PubMed:32747782). Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions (PubMed:20530212). Mediates microtubule polyglutamylation in primary cilia axoneme which is important for ciliary structural formation and motility (PubMed:22246503). Mediates microtubule polyglutamylation in motile cilia, necessary for the regulation of ciliary coordinated beating (PubMed:23897886). Polyglutamylates non-tubulin protein nucleotidyltransferase CGAS, leading to CGAS DNA-binding inhibition, thereby preventing antiviral defense response (PubMed:26829768). Reaction=ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L- glutamyl-L-glutamyl-[protein] + H(+) + phosphate; Xref=Rhea:RHEA:60144, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15517, ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143622, ChEBI:CHEBI:456216; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60145; Evidence=; Reaction=(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60148, Rhea:RHEA-COMP:15519, Rhea:RHEA-COMP:15675, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143623, ChEBI:CHEBI:456216; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60149; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Kinetic parameters: KM=2.22 uM for glutamylated tubulin ; KM=1.92 uM for non-glutamylated tubulin ; Note=kcat is 0.73 min(-1) with glutamylated tubulin as substrate (PubMed:32747782). kcat is 0.04 min(-1) with non-glutamylated tubulin as substrate (PubMed:32747782). ; Found in a complex with CEP41. Cytoplasm Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, cilium basal body Note=CEP41 is required for its transport between the basal body and the cilium axoneme. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=A4Q9E8-1; Sequence=Displayed; Name=2 ; IsoId=A4Q9E8-2; Sequence=VSP_052729; Highly expressed in testis (PubMed:17499049). Expressed in brain, heart, kidney, liver, lung, muscle and trachea (PubMed:17499049). In the brain, specifically expressed in ependymal cilia (PubMed:23897886). The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding. Gln-180 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate- chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation. Belongs to the tubulin--tyrosine ligase family. Sequence=BAC36577.1; Type=Frameshift; Evidence=; Sequence=CAM18274.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding microtubule bundle formation positive regulation of cilium movement protein binding ATP binding cytoplasm cytoskeleton microtubule cilium cellular protein modification process tubulin binding ligase activity protein polyglutamylation ciliary basal body cell projection microtubule severing protein-glutamic acid ligase activity uc011ydd.1 uc011ydd.2 uc011ydd.3 
ENSMUST00000167290.8 Smim7 ENSMUST00000167290.8 small integral membrane protein 7 (from RefSeq NM_172396.3) ENSMUST00000167290.1 ENSMUST00000167290.2 ENSMUST00000167290.3 ENSMUST00000167290.4 ENSMUST00000167290.5 ENSMUST00000167290.6 ENSMUST00000167290.7 NM_172396 Q5RKS2 SMIM7_MOUSE uc009mgh.1 uc009mgh.2 uc009mgh.3 Membrane ; Single-pass type I membrane protein Belongs to the SMIM7 family. molecular_function cellular_component biological_process membrane integral component of membrane uc009mgh.1 uc009mgh.2 uc009mgh.3 
ENSMUST00000167294.8 Kctd19 ENSMUST00000167294.8 potassium channel tetramerisation domain containing 19, transcript variant 2 (from RefSeq NM_001301173.1) ENSMUST00000167294.1 ENSMUST00000167294.2 ENSMUST00000167294.3 ENSMUST00000167294.4 ENSMUST00000167294.5 ENSMUST00000167294.6 ENSMUST00000167294.7 KCD19_MOUSE NM_001301173 Q562E2 Q8C628 uc009ncz.1 uc009ncz.2 uc009ncz.3 Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes (PubMed:33961623, PubMed:34075040, PubMed:35341968). Regulates progression of the pachytene stage of meiotic prophase and promotes the transcriptional activation activity ZNF541 (PubMed:35341968). Required for the organization of chromosomes during metaphase I (PubMed:33961623, PubMed:34075040). Identified in a complex with ZNF541, HDAC1 and HSPA2 (PubMed:18849567). Identified in a complex with ZNF541 and HDAC1 (PubMed:33961623). Identified in a complex with HDAC1, HDAC2, DNTTIP1 and ZNF541 (PubMed:35341968, PubMed:34075040). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q562E2-1; Sequence=Displayed; Name=2; IsoId=Q562E2-2; Sequence=VSP_030044; Detected in adult testis. Not detected in testis from neonates. Expression in testis is first detected 14 days after birth and increases thereafter. Highly expressed 30 and 84 days after birth. Males are infertile and spermatocytes fail to complete meiosis and show defects in metaphase I organization. molecular_function cellular_component biological_process protein homooligomerization uc009ncz.1 uc009ncz.2 uc009ncz.3 
ENSMUST00000167314.3 Vmn2r108 ENSMUST00000167314.3 vomeronasal 2, receptor 108 (from RefSeq NM_001104570.1) E9PYS0 E9PYS0_MOUSE E9Q6V2 ENSMUST00000167314.1 ENSMUST00000167314.2 NM_001104570 Vmn2r108 Vmn2r109 uc009vbl.1 uc009vbl.2 uc009vbl.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vbl.1 uc009vbl.2 uc009vbl.3 
ENSMUST00000167316.8 Zfp655 ENSMUST00000167316.8 zinc finger protein 655, transcript variant 1 (from RefSeq NM_028298.4) ENSMUST00000167316.1 ENSMUST00000167316.2 ENSMUST00000167316.3 ENSMUST00000167316.4 ENSMUST00000167316.5 ENSMUST00000167316.6 ENSMUST00000167316.7 NM_028298 Q9CZP3 Q9CZP3_MOUSE Zfp655 uc009amr.1 uc009amr.2 uc009amr.3 molecular_function nucleic acid binding nucleus nucleolus cytoplasm negative regulation of G1/S transition of mitotic cell cycle uc009amr.1 uc009amr.2 uc009amr.3 
ENSMUST00000167320.8 Nbeal2 ENSMUST00000167320.8 neurobeachin-like 2 (from RefSeq NM_183276.2) E9Q9L6 E9Q9L6_MOUSE ENSMUST00000167320.1 ENSMUST00000167320.2 ENSMUST00000167320.3 ENSMUST00000167320.4 ENSMUST00000167320.5 ENSMUST00000167320.6 ENSMUST00000167320.7 NM_183276 Nbeal2 uc009rul.1 uc009rul.2 uc009rul.3 endoplasmic reticulum platelet formation uc009rul.1 uc009rul.2 uc009rul.3 
ENSMUST00000167323.3 Apold1 ENSMUST00000167323.3 apolipoprotein L domain containing 1 (from RefSeq NM_001109914.1) Apold1 E9Q0X2 E9Q0X2_MOUSE ENSMUST00000167323.1 ENSMUST00000167323.2 NM_001109914 uc012euq.1 uc012euq.2 uc012euq.3 Belongs to the apolipoprotein L family. angiogenesis response to hypoxia extracellular region nucleoplasm cytosol lipid transport lipid binding membrane integral component of membrane endothelial cell activation lipoprotein metabolic process regulation of endothelial cell differentiation uc012euq.1 uc012euq.2 uc012euq.3 
ENSMUST00000167334.8 Sis ENSMUST00000167334.8 sucrase isomaltase (from RefSeq NM_001081137.2) ENSMUST00000167334.1 ENSMUST00000167334.2 ENSMUST00000167334.3 ENSMUST00000167334.4 ENSMUST00000167334.5 ENSMUST00000167334.6 ENSMUST00000167334.7 F8VQM5 F8VQM5_MOUSE NM_001081137 Sis uc012cqn.1 uc012cqn.2 uc012cqn.3 Belongs to the glycosyl hydrolase 31 family. Lacks conserved residue(s) required for the propagation of feature annotation. catalytic activity hydrolase activity, hydrolyzing O-glycosyl compounds beta-fructofuranosidase activity oligo-1,6-glucosidase activity brush border carbohydrate metabolic process membrane integral component of membrane carbohydrate binding membrane raft uc012cqn.1 uc012cqn.2 uc012cqn.3 
ENSMUST00000167358.2 Krtap10-23 ENSMUST00000167358.2 predicted gene 3250 (from RefSeq NM_001370833.1) E9Q1M3 E9Q1M3_MOUSE ENSMUST00000167358.1 Gm3250 NM_001370833 uc287smn.1 uc287smn.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc287smn.1 uc287smn.2 
ENSMUST00000167360.8 Abcc10 ENSMUST00000167360.8 ATP-binding cassette, sub-family C member 10, transcript variant 4 (from RefSeq NR_182268.1) ENSMUST00000167360.1 ENSMUST00000167360.2 ENSMUST00000167360.3 ENSMUST00000167360.4 ENSMUST00000167360.5 ENSMUST00000167360.6 ENSMUST00000167360.7 MRP7_MOUSE Mrp7 NR_182268 Q3TCQ0 Q3V0D1 Q8R4P9 Q8R4S1 uc008cso.1 uc008cso.2 uc008cso.3 ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o- glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity). Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.; EC=7.6.2.2; Evidence=; Reaction=an S-substituted glutathione(in) + ATP + H2O = ADP + an S- substituted glutathione(out) + H(+) + phosphate; Xref=Rhea:RHEA:19121, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:90779, ChEBI:CHEBI:456216; EC=7.6.2.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19122; Evidence=; Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:82961, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60129; Evidence=; Reaction=ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate; Xref=Rhea:RHEA:38963, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57973, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38964; Evidence=; Cell membrane ; Multi-pass membrane protein solateral cell membrane ; Multi-pass membrane protein Basal cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Mrp7B; IsoId=Q8R4P9-1; Sequence=Displayed; Name=2; Synonyms=Mrp7A; IsoId=Q8R4P9-2; Sequence=VSP_021081, VSP_021082; Name=3; IsoId=Q8R4P9-3; Sequence=VSP_021083; Expressed in all tissues tested including liver, brain, heart, skeletal muscle, kidney and spleen. Expressed in embryo. Deficient mice exhibit increased sensitivity to paclitaxel-induced mortality associated with weight loss, decreased white blood cell, and small spleen and thymus cortex due to apoptosis and/or depopulation of lymphoid cells. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. nucleotide binding ATP binding plasma membrane membrane integral component of membrane ATPase activity ATPase activity, coupled to transmembrane movement of substances transmembrane transport uc008cso.1 uc008cso.2 uc008cso.3 
ENSMUST00000167369.8 Fxyd3 ENSMUST00000167369.8 FXYD domain-containing ion transport regulator 3 (from RefSeq NM_008557.2) ENSMUST00000167369.1 ENSMUST00000167369.2 ENSMUST00000167369.3 ENSMUST00000167369.4 ENSMUST00000167369.5 ENSMUST00000167369.6 ENSMUST00000167369.7 FXYD3_MOUSE Mat8 NM_008557 Plml Q61835 uc009gia.1 uc009gia.2 uc009gia.3 uc009gia.4 This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The encoded protein is a transmembrane protein that functions as a specific regulator of Na,K-ATPase. [provided by RefSeq, Aug 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI081078.1, BE689648.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164133 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:15743908). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (By similarity). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (By similarity). Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and an additional regulatory subunit (PubMed:15743908). Interacts with catalytic alpha subunit ATP1A1 (PubMed:15743908). Also interacts with non-catalytic beta subunit ATP1B1 (PubMed:15743908). Interacts with the ATP1A1-ATP1B1, ATP1A2-ATP1B1 and ATP1A3-ATP1B1 NKA isozymes (By similarity). Cell membrane ; Single-pass type I membrane protein Expressed at high levels in heart, skeletal muscle and liver with low levels of expression in breast, brain, lung, stomach and colon (PubMed:7836447). In the gastric gland, mainly expressed in the mucus cells forming the upper part of the gland and is absent from the parietal cells (PubMed:15743908). Glutathionylated. Marker of a cell type preferentially transformed by neu or ras oncoprotein. Belongs to the FXYD family. protein binding endoplasmic reticulum membrane plasma membrane ion transport potassium ion transport sodium ion transport membrane integral component of membrane sodium channel regulator activity regulation of ion transport regulation of catalytic activity ATPase binding ion channel regulator activity regulation of sodium ion transmembrane transporter activity uc009gia.1 uc009gia.2 uc009gia.3 uc009gia.4 
ENSMUST00000167374.9 Ripk1 ENSMUST00000167374.9 receptor (TNFRSF)-interacting serine-threonine kinase 1, transcript variant 1 (from RefSeq NM_009068.3) ENSMUST00000167374.1 ENSMUST00000167374.2 ENSMUST00000167374.3 ENSMUST00000167374.4 ENSMUST00000167374.5 ENSMUST00000167374.6 ENSMUST00000167374.7 ENSMUST00000167374.8 NM_009068 Q3U0J3 Q60855 Q8CD90 RIPK1_MOUSE Rinp Rip Ripk1 uc007qay.1 uc007qay.2 uc007qay.3 Serine-threonine kinase which is a key regulator of TNF- mediated apoptosis, necroptosis and inflammatory pathways (PubMed:24813849, PubMed:24813850, PubMed:24557836, PubMed:27819681, PubMed:28842570, PubMed:31511692, PubMed:31827280, PubMed:31827281, PubMed:33397971). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:24813849, PubMed:24813850, PubMed:24557836, PubMed:28842570, PubMed:31519886, PubMed:31519887). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (PubMed:31519886, PubMed:31519887). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1- RIPK3-MLKL), which drives necroptosis (PubMed:28842570, PubMed:27819681, PubMed:27819682, PubMed:29440439, PubMed:30988283, PubMed:31519886, PubMed:31519887). RIPK1 is required to limit CASP8- dependent TNFR1-induced apoptosis (PubMed:24813849, PubMed:24813850, PubMed:24557836). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:24557836, PubMed:27819681, PubMed:27819682, PubMed:31358656). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:31358656). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (PubMed:30867408, PubMed:30185824). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans- phosphorylation (By similarity). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (By similarity). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (PubMed:12654725, PubMed:19590578). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Serine-threonine kinase activity is inhibited by linear polyubiquitination ('Met-1'-linked) by the LUBAC complex. Homodimer (PubMed:29440439). Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necroptosis-inducing complex (PubMed:31519887, PubMed:28842570). Upon TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity (By similarity). Interacts (via the death domain) with TNFRSF6 (via the death domain) and TRADD (via the death domain) (By similarity). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process (By similarity). Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3 (By similarity). Interacts with BNLF1 (By similarity). Interacts with SQSTM1 upon TNF-alpha stimulation (By similarity). May interact with MAVS/IPS1 (By similarity). Interacts with ZFAND5 (By similarity). Interacts with RBCK1 (By similarity). Interacts with ZBP1 (PubMed:19590578, PubMed:23283962, PubMed:33397971). Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts (via kinase domain) with DAB2IP (via Ras-GAP domain); the interaction occurs in a TNF-alpha-dependent manner (By similarity). Interacts with ARHGEF2 (By similarity). Interacts (via protein kinase domain) with RFFL; involved in RIPK1 ubiquitination (By similarity). Interacts with RNF34; involved in RIPK1 ubiquitination (By similarity). Interacts with TICAM1 and this interaction is enhanced in the presence of WDFY1 (By similarity). Interacts with PELI1 (PubMed:29883609). Interacts (via death domain) with CRADD (via death domain); the interaction is direct (By similarity). Component of complex IIa composed of at least RIPK1, FADD and CASP8 (PubMed:29440439). Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis) (PubMed:34471287). Interacts with MAP3K7, CFLAR and CASP8 (PubMed:31519887). Interacts with FADD (PubMed:29440439, PubMed:31519887, PubMed:28842570). Interacts with NEMO (PubMed:31519886). Interacts with TAX1BP1; this interaction negatively regulates RIPK1 ubiquitination (PubMed:18239685). (Microbial infection) Interacts with Murid herpesvirus 1 protein RIR1. Q60855; Q61160: Fadd; NbExp=9; IntAct=EBI-529119, EBI-524415; Q60855; Q9QZL0: Ripk3; NbExp=4; IntAct=EBI-529119, EBI-2367423; Q60855; P25118: Tnfrsf1a; NbExp=4; IntAct=EBI-529119, EBI-518014; Q60855; Q3U0V2: Tradd; NbExp=2; IntAct=EBI-529119, EBI-1544032; Q60855; P62991: Ubc; NbExp=2; IntAct=EBI-529119, EBI-413074; Q60855; O43464: HTRA2; Xeno; NbExp=2; IntAct=EBI-529119, EBI-517086; Q60855; P01375: TNF; Xeno; NbExp=4; IntAct=EBI-529119, EBI-359977; Cytoplasm ll membrane Found at low levels in all tissues. In concanavalin A-treated splenocytes. The death domain mediates dimerization and activation of its kinase activity during necroptosis and apoptosis (PubMed:29440439). It engages other DD-containing proteins as well as a central (intermediate) region important for NF-kB activation and RHIM-dependent signaling (By similarity). The RIP homotypic interaction motif (RHIM) mediates interaction with the RHIM motif of RIPK1. Both motifs form a hetero-amyloid serpentine fold, stabilized by hydrophobic packing and featuring an unusual Cys-Ser ladder of alternating Ser (from RIPK1) and Cys (from RIPK3). Proteolytically cleaved by CASP8 at Asp-325 (PubMed:30867408, PubMed:31511692, PubMed:31827280). Cleavage is crucial for limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:30867408, PubMed:31511692, PubMed:31827281, PubMed:31827280). Cleavage abolishes NF-kappa-B activation and enhances the interaction of TRADD with FADD (By similarity). Proteolytically cleaved by CASP6 during intrinsic apoptosis (By similarity). RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (By similarity). Phosphorylation of Ser-161 by RIPK3 is necessary for the formation of the necroptosis-inducing complex (By similarity). Phosphorylation at Ser-25 represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (PubMed:30988283). Phosphorylated at Ser-321 by MAP3K7 which requires prior ubiquitination with 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2 (PubMed:28842570). This phosphorylation positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (PubMed:28842570). Deubiquitinated by USP7; this modification is required for TNF- alpha-induced apoptosis. Ubiquitinated with 'Lys-11'-, 'Lys-48'-, 'Lys-63'- and linear- linked type ubiquitin (By similarity). Polyubiquitination with 'Lys- 63'-linked chains by TRAF2 induces association with the IKK complex (By similarity). Deubiquitination of 'Lys-63'-linked chains and polyubiquitination with 'Lys-48'-linked chains by TNFAIP3 leads to RIPK1 proteasomal degradation and consequently down-regulates TNF- alpha-induced NF-kappa-B signaling (By similarity). 'Lys-48'-linked polyubiquitination by RFFL or RNF34 also promotes proteasomal degradation and negatively regulates TNF-alpha-induced NF-kappa-B signaling (By similarity). Linear polyubiquitinated; the head-to-tail linear polyubiquitination ('Met-1'-linked) is mediated by the LUBAC complex and decreases protein kinase activity (PubMed:28701375). Deubiquitination of linear polyubiquitin by CYLD promotes the kinase activity (PubMed:28701375). Polyubiquitinated with 'Lys-48' by BIRC2/c- IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B (By similarity). Ubiquitinated with 'Lys-63'-linked chains by PELI1 (By similarity). Ubiquitination at Lys-376 with 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2 is essential for its phosphorylation at Ser-321 mediated by MAP3K7 (PubMed:28842570, PubMed:31519887, PubMed:31519886). This ubiquitination is required for NF-kB activation, suppresses RIPK1 kinase activity and plays a critical role in preventing cell death during embryonic development (PubMed:31519887, PubMed:31519886). Mice exhibit severe multi-organ inflammation and systemic cell death, which causes lethality of animals late in gestation or shortly after birth (PubMed:24813849, PubMed:30185824). Perinatal lethality observed in Ripk1 knockout mice is rescued in knockout mice lacking both Ripk1 and Ripk3; mice however die the first days of postnatal life (PubMed:24813849, PubMed:24813850, PubMed:27819681, PubMed:27819682). Perinatal lethality observed in Ripk1 knockout mice is rescued in knockout mice lacking both Ripk1 and Casp8; mice however die the first days of postnatal life (PubMed:24813849). Only mice lacking Ripk1, Ripk3 and Casp8 survive past weaning and rescue lethality caused by the absence of Ripk1 (PubMed:24813849, PubMed:24813850). Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. nucleotide binding positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity JUN kinase kinase kinase activity death receptor binding protein binding ATP binding cytoplasm mitochondrion cytosol plasma membrane protein phosphorylation apoptotic process signal transduction activation of JNKK activity activation of JUN kinase activity positive regulation of necrotic cell death positive regulation of cell death programmed cell death membrane viral process kinase activity phosphorylation transferase activity death-inducing signaling complex ubiquitin protein ligase binding positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production macromolecular complex response to tumor necrosis factor peptidyl-serine autophosphorylation positive regulation of phosphorylation identical protein binding positive regulation of apoptotic process positive regulation of programmed cell death positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling receptor complex positive regulation of MAPK cascade cellular protein catabolic process macromolecular complex binding membrane raft positive regulation of macrophage differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade protein autophosphorylation positive regulation of NF-kappaB transcription factor activity protein homooligomerization protein heterooligomerization negative regulation of cardiac muscle cell proliferation positive regulation of necroptotic process T cell apoptotic process necroptotic process cellular response to hydrogen peroxide death domain binding regulation of ATP:ADP antiporter activity cellular response to tumor necrosis factor cellular response to growth factor stimulus extrinsic apoptotic signaling pathway programmed necrotic cell death ripoptosome ripoptosome assembly necroptotic signaling pathway ripoptosome assembly involved in necroptotic process positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of hydrogen peroxide-induced cell death amyloid fibril formation negative regulation of G1/S transition of mitotic cell cycle regulation of reactive oxygen species metabolic process negative regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc007qay.1 uc007qay.2 uc007qay.3 
ENSMUST00000167377.3 Iqgap1 ENSMUST00000167377.3 IQ motif containing GTPase activating protein 1 (from RefSeq NM_016721.2) ENSMUST00000167377.1 ENSMUST00000167377.2 G3UW45 IQGA1_MOUSE NM_016721 Q9JKF1 uc009ibc.1 uc009ibc.2 uc009ibc.3 uc009ibc.4 Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity (PubMed:16968698). It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest. Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state (PubMed:16968698). Interacts with RAC1 (By similarity). Does not interact with RHOA (By similarity). Interacts with TSG101 (By similarity). Interacts with PAK6 (By similarity). Interacts with SASH1 (By similarity). Interacts with PJVK (PubMed:28089576). Interacts with SLC26A4 (PubMed:35601831). This interaction enhances the chloride-bicarbonate exchange activity of SLC26A4 (By similarity). Interacts with SVEP1 (PubMed:36792666). (Microbial infection) In case of infection, interacts with S.typhimurium protein sseI (PubMed:19956712). Q9JKF1; P98083: Shc1; NbExp=5; IntAct=EBI-644633, EBI-300201; Q9JKF1; P03332: gag; Xeno; NbExp=17; IntAct=EBI-644633, EBI-935477; Cell membrane Nucleus Cytoplasm Apical cell membrane Basolateral cell membrane Note=Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816). Expressed in the kidney (at protein level). Expressed widely in developing cortex. Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together. ruffle regulation of cytokine production protein binding calmodulin binding phosphatidylinositol-3,4,5-trisphosphate binding nucleus cytoplasm microtubule plasma membrane cell-cell junction focal adhesion signal transduction epidermal growth factor receptor signaling pathway regulation of mitotic cell cycle fibroblast growth factor receptor signaling pathway actin cytoskeleton microtubule cytoskeleton membrane lateral plasma membrane cell migration Rho GTPase binding protein kinase binding protein phosphatase binding protein domain specific binding axon growth cone midbody extrinsic component of cytoplasmic side of plasma membrane cell leading edge small GTPase binding macromolecular complex negative regulation of dephosphorylation slit diaphragm cellular response to platelet-derived growth factor stimulus cytoplasmic ribonucleoprotein granule neuron projection regulation of GTPase activity positive regulation of MAP kinase activity protein serine/threonine kinase activator activity cellular response to fibroblast growth factor stimulus S100 protein binding macromolecular complex binding membrane raft positive regulation of protein kinase activity platelet-derived growth factor receptor signaling pathway Rac GTPase binding mitogen-activated protein kinase binding positive regulation of focal adhesion assembly binding, bridging cellular response to calcium ion cellular response to epidermal growth factor stimulus glomerular visceral epithelial cell development positive regulation of dendrite development positive regulation of peptidyl-tyrosine autophosphorylation positive regulation of cellular protein localization positive regulation of vascular associated smooth muscle cell migration neuron projection extension response to angiotensin ribonucleoprotein complex uc009ibc.1 uc009ibc.2 uc009ibc.3 uc009ibc.4 
ENSMUST00000167382.2 Vmn2r105 ENSMUST00000167382.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q3A5) E9Q3A5 E9Q3A5_MOUSE ENSMUST00000167382.1 Vmn2r105 uc009vbj.1 uc009vbj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vbj.1 uc009vbj.2 
ENSMUST00000167383.9 Slco6b1 ENSMUST00000167383.9 solute carrier organic anion transporter family, member 6b1 (from RefSeq NR_120500.1) ENSMUST00000167383.1 ENSMUST00000167383.2 ENSMUST00000167383.3 ENSMUST00000167383.4 ENSMUST00000167383.5 ENSMUST00000167383.6 ENSMUST00000167383.7 ENSMUST00000167383.8 NR_120500 uc007cfe.1 uc007cfe.2 uc007cfe.3 uc007cfe.4 uc007cfe.5 uc007cfe.1 uc007cfe.2 uc007cfe.3 uc007cfe.4 uc007cfe.5 
ENSMUST00000167388.3 Gp1bb ENSMUST00000167388.3 glycoprotein Ib, beta polypeptide, transcript variant 2 (from RefSeq NM_010327.2) ENSMUST00000167388.1 ENSMUST00000167388.2 GP1BB_MOUSE NM_010327 P56400 uc007yoi.1 uc007yoi.2 uc007yoi.3 Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium. Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage. Interacts with TRAF4 (By similarity). Membrane; Single-pass type I membrane protein. Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein. integral component of plasma membrane cell adhesion blood coagulation hemostasis membrane integral component of membrane identical protein binding uc007yoi.1 uc007yoi.2 uc007yoi.3 
ENSMUST00000167400.8 Mgat1 ENSMUST00000167400.8 mannoside acetylglucosaminyltransferase 1, transcript variant 1 (from RefSeq NM_001110148.1) ENSMUST00000167400.1 ENSMUST00000167400.2 ENSMUST00000167400.3 ENSMUST00000167400.4 ENSMUST00000167400.5 ENSMUST00000167400.6 ENSMUST00000167400.7 Mgat1 NM_001110148 Q544F0 Q544F0_MOUSE uc007iqc.1 uc007iqc.2 uc007iqc.3 uc007iqc.4 uc007iqc.5 Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. Reaction=N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man- (1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D- GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man- (1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:11456, Rhea:RHEA-COMP:14367, Rhea:RHEA-COMP:14368, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:59087, ChEBI:CHEBI:60625; EC=2.4.1.101; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=The cofactor is mostly bound to the substrate. ; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein mbrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 13 family. Golgi membrane alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity protein glycosylation acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity protein N-linked glycosylation via asparagine manganese ion binding uc007iqc.1 uc007iqc.2 uc007iqc.3 uc007iqc.4 uc007iqc.5 
ENSMUST00000167403.4 H3c15 ENSMUST00000167403.4 H3 clustered histone 15 (from RefSeq NM_054045.5) A3KMN6 ENSMUST00000167403.1 ENSMUST00000167403.2 ENSMUST00000167403.3 H3-143 H3-53 H3-B H3-F H3.2 H3.2-221 H3.2-614 H3.2-615 H3.2-616 H32_MOUSE H3b H3c13 H3c14 H3c15 H3c2 H3c3 H3c4 H3c6 H3c7 H3f Hist1h3b Hist1h3c Hist1h3d Hist1h3e Hist1h3f Hist2h3b Hist2h3c1 Hist2h3c2 Hist2h3ca1 Hist2h3ca2 NM_054045 P02295 P02297 P16105 P17269 P17320 P84228 Q60582 Q78E59 Q8CGN9 uc008qmk.1 uc008qmk.2 uc008qmk.3 uc008qmk.4 uc008qmk.5 uc008qmk.6 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. [provided by RefSeq, Aug 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer (By similarity). Interacts with DNAJC9, CHAF1A and CHAF1B (By similarity). P84228; Q8TF76-1: HASPIN; Xeno; NbExp=3; IntAct=EBI-2658213, EBI-15815652; Nucleus. Chromosome. Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity). Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys- 10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H3 family. Sequence=AAH94041.1; Type=Erroneous initiation; Evidence=; Sequence=AAO06264.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter nuclear chromosome chromatin nucleosome nuclear nucleosome DNA binding chromatin binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly macromolecular complex protein heterodimerization activity protein heterotetramerization regulation of gene silencing uc008qmk.1 uc008qmk.2 uc008qmk.3 uc008qmk.4 uc008qmk.5 uc008qmk.6 
ENSMUST00000167423.2 Gm17409 ENSMUST00000167423.2 Gm17409 (from geneSymbol) AK131764 ENSMUST00000167423.1 uc289wfv.1 uc289wfv.2 uc289wfv.1 uc289wfv.2 
ENSMUST00000167430.8 Gm3020 ENSMUST00000167430.8 predicted gene 3020 (from RefSeq NR_033117.1) ENSMUST00000167430.1 ENSMUST00000167430.2 ENSMUST00000167430.3 ENSMUST00000167430.4 ENSMUST00000167430.5 ENSMUST00000167430.6 ENSMUST00000167430.7 Gm10409 Gm3020 NR_033117 Q9CZI1 Q9CZI1_MOUSE uc007sbe.1 uc007sbe.2 uc007sbe.3 uc007sbe.4 uc007sbe.5 molecular_function cellular_component biological_process uc007sbe.1 uc007sbe.2 uc007sbe.3 uc007sbe.4 uc007sbe.5 
ENSMUST00000167446.8 Fancb ENSMUST00000167446.8 Fanconi anemia, complementation group B, transcript variant 1 (from RefSeq NM_001146081.2) ENSMUST00000167446.1 ENSMUST00000167446.2 ENSMUST00000167446.3 ENSMUST00000167446.4 ENSMUST00000167446.5 ENSMUST00000167446.6 ENSMUST00000167446.7 Fancb NM_001146081 Q3TEX6 Q3TEX6_MOUSE uc009uwa.1 uc009uwa.2 uc009uwa.3 uc009uwa.4 interstrand cross-link repair Fanconi anaemia nuclear complex uc009uwa.1 uc009uwa.2 uc009uwa.3 uc009uwa.4 
ENSMUST00000167464.3 Vmn2r106 ENSMUST00000167464.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PY92) E9PY92 E9PY92_MOUSE ENSMUST00000167464.1 ENSMUST00000167464.2 Vmn2r106 uc009vbk.1 uc009vbk.2 uc009vbk.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vbk.1 uc009vbk.2 uc009vbk.3 
ENSMUST00000167487.8 Vldlr ENSMUST00000167487.8 very low density lipoprotein receptor, transcript variant 1 (from RefSeq NM_013703.2) ENSMUST00000167487.1 ENSMUST00000167487.2 ENSMUST00000167487.3 ENSMUST00000167487.4 ENSMUST00000167487.5 ENSMUST00000167487.6 ENSMUST00000167487.7 NM_013703 P98156 Q64022 VLDLR_MOUSE uc008hbt.1 uc008hbt.2 uc008hbt.3 uc008hbt.4 Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism (PubMed:11108739, PubMed:24293365). Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway LRP8 and VLDLR form homo or heterooligomers (By similarity). Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 on its cytoplasmic tail (By similarity). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons (PubMed:23506116). Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (PubMed:17913789). Homooligomer (By similarity). Binds to the extracellular matrix protein Reelin/RELN (PubMed:10571241). Interacts with LRP8 (By similarity). Interacts with LDLRAP1 (PubMed:12746448). Interacts with SNX17 (PubMed:12169628). Interacts with DAB1. Interacts with PCSK9 (By similarity). Interacts with PAFAH1B3 and PAFAH1B2, the catalytic complex of (PAF-AH (I)) heterotetrameric enzyme; these interactions may modulate the Reelin pathway (By similarity). Interacts with STX5; this interaction mediates VLDLR translocation from the endoplasmic reticulum to the plasma membrane (By similarity). Interacts with CLU (By similarity). Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Abundant in heart and muscle; less in kidney, brain, ovary, testis, lung and adipose tissue. Strongly expressed in neurons (PubMed:23506116). Ubiquitinated at Lys-839 by MYLIP leading to degradation. Deletion mutant mice show an increase in serum triglycerides under a high fat diet, suggesting a role in extrahepatic triglyceride uptake (PubMed:11108739). In addition, these mice show a reduced high fat diet-induced inflammation and endoplasmic reticulum (ER) stress in adipose tissue in conjunction with reduced macrophage infiltration (PubMed:24293365). LRP8 and VLVLR together are required for correct embryonic development in the brain. Targeted disruption of both genes results in a phenotype virtually indistinguishable from that seen in 'reeler' and 'scrambler' mice. Subtle effects of VLDLR deletion are found mainly in the cerebellum, whereas lack of LRP8 predominantly affects the positioning of the neurons in the neocortex. calcium ion binding protein binding extracellular space nucleus clathrin-coated pit lipid metabolic process lipid transport endocytosis receptor-mediated endocytosis steroid metabolic process cholesterol metabolic process cell surface membrane integral component of membrane ventral spinal cord development very-low-density lipoprotein particle receptor activity apolipoprotein binding very-low-density lipoprotein particle binding very-low-density lipoprotein particle glycoprotein transport very-low-density lipoprotein particle clearance cargo receptor activity reelin receptor activity reelin-mediated signaling pathway receptor complex apical part of cell positive regulation of protein kinase activity calcium-dependent protein binding perinuclear region of cytoplasm dendrite morphogenesis cellular response to hypoxia positive regulation of dendrite development uc008hbt.1 uc008hbt.2 uc008hbt.3 uc008hbt.4 
ENSMUST00000167488.9 Bend3 ENSMUST00000167488.9 BEN domain containing 3, transcript variant 1 (from RefSeq NM_199028.2) BEND3_MOUSE ENSMUST00000167488.1 ENSMUST00000167488.2 ENSMUST00000167488.3 ENSMUST00000167488.4 ENSMUST00000167488.5 ENSMUST00000167488.6 ENSMUST00000167488.7 ENSMUST00000167488.8 Kiaa1553 NM_199028 Q6PAL0 Q80TC0 uc011xdl.1 uc011xdl.2 uc011xdl.3 Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (By similarity). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (PubMed:25457167). Stimulates the ERCC6L translocase and ATPase activities (By similarity). Homooligomer, probably a homooctamer. Interacts with HDAC2 and HDAC3, but not HDAC1. Interacts with SALL4. Interacts with SMARCA5/SNF2H, BAZ2A/TIP5 and USP21 (By similarity). Interacts with the nucleosome remodeling and histone deacetylase (NuRD) repressor complex (PubMed:25457167). Interacts (via BEN domains 1 and 3) with ERCC6L (via N-terminal TPR repeat); the interaction is direct (By similarity). Nucleus Nucleus, nucleolus Note=In the nucleus, observed in heterochromatic foci containing CBX1, CBX3, CBX5 and histone H3 trimethylated at 'Lys-9'. Released from chromatin during decondensation. Association with heterochromatin does not depend on sumoylation. The BEN domain 4 is necessary and sufficient for the localization of BEND3 to heterochromatic regions. Sumoylated at Lys-20 by SUMO1 and at Lys-509 by SUMO1, SUMO2 and SUMO3. Sumoylation probably occurs sequentially, with that of Lys-20 preceding that of Lys-509. It does not alter association with heterochromatin, but is required for the repression of transcription. negative regulation of transcription from RNA polymerase II promoter rDNA binding chromatin silencing at rDNA DNA binding nucleus nucleoplasm nuclear heterochromatin nucleolus DNA methylation chromatin organization histone H4-K20 trimethylation histone H3-K9 trimethylation histone H4 acetylation protein homooligomerization histone H3-K4 trimethylation histone H3-K27 trimethylation positive regulation of ATP metabolic process uc011xdl.1 uc011xdl.2 uc011xdl.3 
ENSMUST00000167493.9 Rnh1 ENSMUST00000167493.9 ribonuclease/angiogenin inhibitor 1, transcript variant 2 (from RefSeq NM_001172100.1) ENSMUST00000167493.1 ENSMUST00000167493.2 ENSMUST00000167493.3 ENSMUST00000167493.4 ENSMUST00000167493.5 ENSMUST00000167493.6 ENSMUST00000167493.7 ENSMUST00000167493.8 NM_001172100 Q91VI7 Q924P4 RINI_MOUSE Rnh uc009kjt.1 uc009kjt.2 uc009kjt.3 uc009kjt.4 Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis (By similarity). Forms high-affinity heterodimers with RNASE1, ANG and RNASE2. Cytoplasm The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side. nucleoplasm cytoplasm cytosol ribonuclease inhibitor activity angiogenin-PRI complex negative regulation of catalytic activity regulation of angiogenesis uc009kjt.1 uc009kjt.2 uc009kjt.3 uc009kjt.4 
ENSMUST00000167496.8 Rnf20 ENSMUST00000167496.8 ring finger protein 20, transcript variant 3 (from RefSeq NM_001356401.1) A2AIR3 BRE1A_MOUSE Bre1a ENSMUST00000167496.1 ENSMUST00000167496.2 ENSMUST00000167496.3 ENSMUST00000167496.4 ENSMUST00000167496.5 ENSMUST00000167496.6 ENSMUST00000167496.7 Kiaa4116 NM_001356401 Q3UT10 Q3V350 Q5DTM8 Q7TT11 Q8BKA8 Q8BKN8 Q8BUF7 Q8BVU4 uc008swa.1 uc008swa.2 uc008swa.3 Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1) (PubMed:28453857). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of PA2G4 leading to its proteasome-mediated degradation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with p53/TP53 and WAC. Interacts with PAF1; the interaction mediates the association of the PAF1 and RNF20/40 complexes which is a prerequsite for recruitment of UBE2A/B. Interacts with PA2G4. Interacts with FBXL19 (PubMed:28453857). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5DTM8-1; Sequence=Displayed; Name=2; IsoId=Q5DTM8-2; Sequence=VSP_016679; Belongs to the BRE1 family. Sequence=BAD90290.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; ubiquitin ligase complex protein polyubiquitination p53 binding chromatin binding transcription coactivator activity mRNA 3'-UTR binding ubiquitin-protein transferase activity protein binding nucleus nucleoplasm nucleolus chromatin organization regulation of transcription, DNA-templated ubiquitin-dependent protein catabolic process histone monoubiquitination protein ubiquitination histone ubiquitination transferase activity negative regulation of cell migration positive regulation of histone methylation ubiquitin protein ligase binding HULC complex histone H2B ubiquitination histone binding positive regulation of transcription, DNA-templated metal ion binding negative regulation of mRNA polyadenylation positive regulation of histone H2B ubiquitination uc008swa.1 uc008swa.2 uc008swa.3 
ENSMUST00000167504.3 Tma7 ENSMUST00000167504.3 translational machinery associated 7 (from RefSeq NM_183250.2) Ccdc72 ENSMUST00000167504.1 ENSMUST00000167504.2 NM_183250 Q8K003 TMA7_MOUSE uc009rrw.1 uc009rrw.2 uc009rrw.3 Belongs to the TMA7 family. cytoplasmic translation molecular_function cellular_component uc009rrw.1 uc009rrw.2 uc009rrw.3 
ENSMUST00000167505.3 Tmem255b ENSMUST00000167505.3 transmembrane protein 255B, transcript variant 6 (from RefSeq NM_001402817.1) ENSMUST00000167505.1 ENSMUST00000167505.2 Fam70b G3UWB7 G3UWB7_MOUSE NM_001402817 Tmem255b uc009kxx.1 uc009kxx.2 uc009kxx.3 uc009kxx.4 uc009kxx.5 Membrane ; Multi- pass membrane protein Belongs to the TMEM255 family. membrane integral component of membrane uc009kxx.1 uc009kxx.2 uc009kxx.3 uc009kxx.4 uc009kxx.5 
ENSMUST00000167549.2 Endod1 ENSMUST00000167549.2 endonuclease domain containing 1 (from RefSeq NM_028013.3) ENDD1_MOUSE ENSMUST00000167549.1 Kiaa0830 NM_028013 Q4VA96 Q8C522 Q8C5M1 Q8VE35 uc009oel.1 uc009oel.2 uc009oel.3 May act as a DNase and a RNase. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. Interacts with RNF26; this interaction is important to modulate innate immune signaling through the cGAS-STING pathway. Secreted Belongs to the DNA/RNA non-specific endonuclease family. nucleic acid binding nuclease activity endonuclease activity extracellular region biological_process hydrolase activity metal ion binding nucleic acid phosphodiester bond hydrolysis uc009oel.1 uc009oel.2 uc009oel.3 
ENSMUST00000167565.3 Zfp712 ENSMUST00000167565.3 zinc finger protein 712 (from RefSeq NM_001166218.1) E9PXJ4 E9PXJ4_MOUSE ENSMUST00000167565.1 ENSMUST00000167565.2 NM_001166218 Zfp712 uc007rab.1 uc007rab.2 uc007rab.3 uc007rab.4 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007rab.1 uc007rab.2 uc007rab.3 uc007rab.4 
ENSMUST00000167566.8 Speer1b ENSMUST00000167566.8 Speer1b (from geneSymbol) AK014925 ENSMUST00000167566.1 ENSMUST00000167566.2 ENSMUST00000167566.3 ENSMUST00000167566.4 ENSMUST00000167566.5 ENSMUST00000167566.6 ENSMUST00000167566.7 Gm8926 L7MUE8 L7MUE8_MOUSE uc290tec.1 uc290tec.2 uc290tec.1 uc290tec.2 
ENSMUST00000167578.2 Gm17141 ENSMUST00000167578.2 predicted gene 17141 (from RefSeq NR_188926.1) ENSMUST00000167578.1 NR_188926 uc292ktr.1 uc292ktr.2 uc292ktr.1 uc292ktr.2 
ENSMUST00000167588.9 Trim67 ENSMUST00000167588.9 tripartite motif-containing 67 (from RefSeq NM_198632.2) ENSMUST00000167588.1 ENSMUST00000167588.2 ENSMUST00000167588.3 ENSMUST00000167588.4 ENSMUST00000167588.5 ENSMUST00000167588.6 ENSMUST00000167588.7 ENSMUST00000167588.8 NM_198632 Q505D9 TRI67_MOUSE uc012gmz.1 uc012gmz.2 uc012gmz.3 Cytoplasm Cytoplasm, cytoskeleton Note=Microtubule-associated. protein binding cytoplasm cytoskeleton zinc ion binding positive regulation of neuron projection development negative regulation of Ras protein signal transduction metal ion binding positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc012gmz.1 uc012gmz.2 uc012gmz.3 
ENSMUST00000167595.9 Fyco1 ENSMUST00000167595.9 FYVE and coiled-coil domain containing 1, transcript variant 2 (from RefSeq NM_001110253.2) ENSMUST00000167595.1 ENSMUST00000167595.2 ENSMUST00000167595.3 ENSMUST00000167595.4 ENSMUST00000167595.5 ENSMUST00000167595.6 ENSMUST00000167595.7 ENSMUST00000167595.8 FYCO1_MOUSE NM_001110253 Q3V385 Q7TMT0 Q8BJN2 Q8VDC1 uc029xgu.1 uc029xgu.2 uc029xgu.3 uc029xgu.4 May mediate microtubule plus end-directed vesicle transport. Can form homodimers. Interacts (via C-terminus) with MAP1LC3B. Interacts with RAB7A; the interaction with RAB7A induces FYCO1 recruitment to late endosomal/lysosomal compartments. Cytoplasmic vesicle, autophagosome Endosome Lysosome Note=Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes. Expressed in heart and testis. Expressed in the eye lens. Sequence=AAH53712.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; lysosome endosome late endosome autophagosome Golgi apparatus cytoplasmic vesicle intracellular membrane-bounded organelle metal ion binding plus-end-directed vesicle transport along microtubule positive regulation of autophagosome maturation uc029xgu.1 uc029xgu.2 uc029xgu.3 uc029xgu.4 
ENSMUST00000167598.6 S100a14 ENSMUST00000167598.6 S100 calcium binding protein A14, transcript variant 2 (from RefSeq NM_025393.4) ENSMUST00000167598.1 ENSMUST00000167598.2 ENSMUST00000167598.3 ENSMUST00000167598.4 ENSMUST00000167598.5 Gm1020 NM_025393 Q9D1D8 Q9D2Q8 S100a15 S10AE_MOUSE uc008qcv.1 uc008qcv.2 uc008qcv.3 uc008qcv.4 uc008qcv.5 Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium (By similarity). Homodimer. Interacts with AGER (By similarity). Cytoplasm Belongs to the S-100 family. calcium ion binding cytoplasm cytosol plasma membrane apoptotic process nuclear body cell junction response to lipopolysaccharide toll-like receptor 4 signaling pathway chemokine receptor binding defense response to bacterium perinuclear region of cytoplasm positive regulation of granulocyte chemotaxis positive regulation of monocyte chemotaxis uc008qcv.1 uc008qcv.2 uc008qcv.3 uc008qcv.4 uc008qcv.5 
ENSMUST00000167617.4 Gm17078 ENSMUST00000167617.4 Gm17078 (from geneSymbol) ENSMUST00000167617.1 ENSMUST00000167617.2 ENSMUST00000167617.3 Gm17078 M0QW51 M0QW51_MOUSE uc288tps.1 uc288tps.2 uc288tps.1 uc288tps.2 
ENSMUST00000167641.8 Spdya ENSMUST00000167641.8 speedy/RINGO cell cycle regulator family, member A, transcript variant 1 (from RefSeq NM_029254.1) B8JJC0 ENSMUST00000167641.1 ENSMUST00000167641.2 ENSMUST00000167641.3 ENSMUST00000167641.4 ENSMUST00000167641.5 ENSMUST00000167641.6 ENSMUST00000167641.7 NM_029254 Q5IBH7 Q5IBH8 Q8C5T5 SPDYA_MOUSE Spdy1 Spdya uc008dmo.1 uc008dmo.2 uc008dmo.3 Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:15611625). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate- binding cleft prior to kinase activation. Interferes with CDKN1B- mediated inhibition of CDK2. Mediates cell survival during the DNA damage process through activation of CDK2 (By similarity). Interacts with CDK1, CDK2 and CDKN1B/KIP1 (PubMed:15611625). Identified in a complex with CDK2 and CDKN1B/KIP1, where it interacts primarily with CDK2 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=2 ; Synonyms=A2 ; IsoId=Q5IBH7-2; Sequence=Displayed; Name=1 ; Synonyms=A1 ; IsoId=Q5IBH7-1; Sequence=VSP_052029, VSP_052030; Expressed at a high level in testis. Also expressed in the adult ovary and in immature oocytes. The C-terminus is required for CDK2-activation, but not CDK2- binding. Belongs to the Speedy/Ringo family. G1/S transition of mitotic cell cycle nucleus nucleoplasm cellular response to DNA damage stimulus cell cycle male meiosis multicellular organism development positive regulation of cell proliferation protein kinase binding protein kinase activator activity activation of protein kinase activity positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of protein kinase activity uc008dmo.1 uc008dmo.2 uc008dmo.3 
ENSMUST00000167642.8 Gm42890 ENSMUST00000167642.8 Gm42890 (from geneSymbol) AK163839 ENSMUST00000167642.1 ENSMUST00000167642.2 ENSMUST00000167642.3 ENSMUST00000167642.4 ENSMUST00000167642.5 ENSMUST00000167642.6 ENSMUST00000167642.7 uc290ilr.1 uc290ilr.2 uc290ilr.1 uc290ilr.2 
ENSMUST00000167662.8 Ergic1 ENSMUST00000167662.8 endoplasmic reticulum-golgi intermediate compartment 1 (from RefSeq NM_026170.3) ENSMUST00000167662.1 ENSMUST00000167662.2 ENSMUST00000167662.3 ENSMUST00000167662.4 ENSMUST00000167662.5 ENSMUST00000167662.6 ENSMUST00000167662.7 ERGI1_MOUSE Ergic32 NM_026170 Q9DC16 uc008bef.1 uc008bef.2 uc008bef.3 uc008bef.4 Possible role in transport between endoplasmic reticulum and Golgi. May form a heteromeric complex composed of ERGIC1, ERGIC2 and ERGIC3 (By similarity). Within the complex, the interaction with ERGIC3 is direct (By similarity). Interacts with ERGIC3/ERV46 (By similarity). Endoplasmic reticulum membrane ; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi- pass membrane protein Note=Cycles between the endoplasmic reticulum and the Golgi. N-glycosylated. Belongs to the ERGIC family. Golgi membrane molecular_function nucleoplasm endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER membrane integral component of membrane vesicle-mediated transport ER to Golgi transport vesicle integral component of Golgi membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment membrane intracellular membrane-bounded organelle uc008bef.1 uc008bef.2 uc008bef.3 uc008bef.4 
ENSMUST00000167669.2 Krtap10-26 ENSMUST00000167669.2 Krtap10-26 (from geneSymbol) ENSMUST00000167669.1 Gm7138 L7N2C3 L7N2C3_MOUSE uc287smm.1 uc287smm.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc287smm.1 uc287smm.2 
ENSMUST00000167673.2 P2ry10b ENSMUST00000167673.2 purinergic receptor P2Y, G-protein coupled 10B, transcript variant 1 (from RefSeq NM_001122596.1) A630033H20Rik ENSMUST00000167673.1 NM_001122596 P2ry10b Q8BY68 Q8BY68_MOUSE uc012hnp.1 uc012hnp.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity integral component of plasma membrane G-protein coupled receptor signaling pathway membrane integral component of membrane positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway uc012hnp.1 uc012hnp.2 
ENSMUST00000167715.8 Sin3a ENSMUST00000167715.8 Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904). Required for cortical neuron differentiation and callosal axon elongation (PubMed:27399968). (from UniProt Q60520) BC078454 ENSMUST00000167715.1 ENSMUST00000167715.2 ENSMUST00000167715.3 ENSMUST00000167715.4 ENSMUST00000167715.5 ENSMUST00000167715.6 ENSMUST00000167715.7 Kiaa4126 Q570Z7 Q60520 Q60820 Q62139 Q62140 Q7TPU8 Q7TSZ2 SIN3A_MOUSE uc292hmk.1 uc292hmk.2 Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904). Required for cortical neuron differentiation and callosal axon elongation (PubMed:27399968). Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS (PubMed:8649810). Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase (By similarity). Interacts with BAZ2A, MXD1, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3 (PubMed:7889570, PubMed:8521822, PubMed:9139820, PubMed:9702189, PubMed:10734093, PubMed:10950960, PubMed:11106735, PubMed:11882901, PubMed:11909966, PubMed:12130660, PubMed:12198165, PubMed:12398767, PubMed:16805913, PubMed:19144721). Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30 (PubMed:11390640). Interacts with TET1; the interaction recruits SIN3A to gene promoters (PubMed:21490601). The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A (PubMed:21680841). Interacts with KLF11 (PubMed:15774581). Interacts with PPHLN1 (By similarity). Found in a complex with YY1, GON4L and HDAC1 (PubMed:21454521). Interacts (via PAH2) with FOXK1 (PubMed:22476904, PubMed:25402684). Interacts with FOXK2 (PubMed:25402684). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (PubMed:28554894). Interacts with SINHCAF (PubMed:28554894). Interacts with SPHK2 (By similarity). Q60520; O09106: Hdac1; NbExp=9; IntAct=EBI-349034, EBI-301912; Q60520; P70288: Hdac2; NbExp=7; IntAct=EBI-349034, EBI-302251; Q60520; Q9Z2D6: Mecp2; NbExp=5; IntAct=EBI-349034, EBI-1188816; Q60520; Q1EHW4: Sap25; NbExp=4; IntAct=EBI-349034, EBI-937195; Q60520; O88574: Sap30; NbExp=6; IntAct=EBI-349034, EBI-593511; Q60520; P48432: Sox2; NbExp=3; IntAct=EBI-349034, EBI-2313612; Q60520; Q8BR65: Suds3; NbExp=4; IntAct=EBI-349034, EBI-591431; Q60520; Q3URK3: Tet1; NbExp=2; IntAct=EBI-349034, EBI-4291699; Q60520; Q99583: MNT; Xeno; NbExp=3; IntAct=EBI-349034, EBI-7959025; Nucleus Nucleus, nucleolus Note=Recruited to the nucleolus by SAP30L. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60520-2; Sequence=Displayed; Name=2; IsoId=Q60520-1; Sequence=VSP_039918; Widely expressed. Highest levels in testis, lung and thymus. Expressed at relatively high levels throughout brain development. In adult mice, expression is high in neurogenic regions such as the subventricular zone, rostral migratory stream, olfactory bulb and dentate gyrus (PubMed:27399968). SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2. SIN3A knockdown causes a significant decrease in the amount of cortical progenitors in the proliferative zone at the peak of neurogenesis, and results in altered neuronal identity and aberrant corticocortical projections. Sequence=AAB01610.1; Type=Miscellaneous discrepancy; Note=The cDNA contains an internal 15bp tandem duplication.; Evidence=; Sequence=AAH52716.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact leading to an internal deletion.; Evidence=; Sequence=AAH53385.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAD90217.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter kinetochore chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II activating transcription factor binding RNA polymerase II repressing transcription factor binding in utero embryonic development activation of innate immune response positive regulation of defense response to virus by host hematopoietic progenitor cell differentiation DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity RNA binding protein binding nucleus nucleoplasm transcription factor complex nucleolus DNA replication regulation of transcription, DNA-templated protein deacetylation aging transcription factor binding response to organonitrogen compound regulation of hormone levels positive regulation of G2/M transition of mitotic cell cycle histone deacetylation Sin3 complex transcriptional repressor complex cerebral cortex neuron differentiation regulation of axon extension positive regulation of chromatin silencing macromolecular complex protein deacetylase activity cellular protein localization negative regulation of circadian rhythm negative regulation of apoptotic process regulation of transcription from RNA polymerase II promoter in response to oxidative stress macromolecular complex binding positive regulation of neuron differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process response to methylglyoxal cellular response to glucose stimulus negative regulation of protein localization to nucleus negative regulation of histone H3-K27 acetylation cellular response to dopamine negative regulation of transcription regulatory region DNA binding histone deacetylase activity uc292hmk.1 uc292hmk.2 
ENSMUST00000167746.8 Cmah ENSMUST00000167746.8 cytidine monophospho-N-acetylneuraminic acid hydroxylase, transcript variant 2 (from RefSeq NM_001111110.2) CMAH_MOUSE ENSMUST00000167746.1 ENSMUST00000167746.2 ENSMUST00000167746.3 ENSMUST00000167746.4 ENSMUST00000167746.5 ENSMUST00000167746.6 ENSMUST00000167746.7 NM_001111110 Q61419 Q7TMR9 Q8JZM9 uc011yxl.1 uc011yxl.2 uc011yxl.3 uc011yxl.4 Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell- pathogen interactions. Catalyzes the conversion of CMP-N- acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. Reaction=CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O; Xref=Rhea:RHEA:16145, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57812, ChEBI:CHEBI:58376; EC=1.14.18.2; Evidence=; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Note=Binds 1 [2Fe-2S] cluster per subunit. ; Kinetic parameters: KM=5 uM for CMP-NeuAc ; Amino-sugar metabolism; N-acetylneuraminate metabolism. Cytoplasm [Isoform 2]: Endoplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61419-1; Sequence=Displayed; Name=2; IsoId=Q61419-2; Sequence=VSP_013769; Expressed in all tissues tested, except in brain. Mice do not synthesize N-glycolylneuraminic acid (Neu5Gc). [Isoform 2]: Inactive. Belongs to the CMP-Neu5Ac hydroxylase family. Sequence=BAB91361.1; Type=Erroneous initiation; Evidence=; Sequence=BAB91362.1; Type=Erroneous initiation; Evidence=; Sequence=BAB91553.1; Type=Erroneous initiation; Evidence=; cytoplasm endoplasmic reticulum N-acetylneuraminate metabolic process oxidoreductase activity CMP-N-acetylneuraminate monooxygenase activity CMP-N-acetylneuraminate metabolic process metal ion binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding oxidation-reduction process uc011yxl.1 uc011yxl.2 uc011yxl.3 uc011yxl.4 
ENSMUST00000167753.8 Hsd3b9 ENSMUST00000167753.8 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 9 (from RefSeq NM_001370870.1) E9Q007 E9Q007_MOUSE ENSMUST00000167753.1 ENSMUST00000167753.2 ENSMUST00000167753.3 ENSMUST00000167753.4 ENSMUST00000167753.5 ENSMUST00000167753.6 ENSMUST00000167753.7 Gm4450 Hsd3b9 NM_001370870 uc290hyk.1 uc290hyk.2 Belongs to the 3-beta-HSD family. 3-beta-hydroxy-delta5-steroid dehydrogenase activity steroid biosynthetic process C21-steroid hormone metabolic process oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor hippocampus development intracellular membrane-bounded organelle response to corticosterone oxidation-reduction process uc290hyk.1 uc290hyk.2 
ENSMUST00000167763.3 4930579G18Rik ENSMUST00000167763.3 RIKEN cDNA 4930579G18 gene (from RefSeq NR_038053.1) ENSMUST00000167763.1 ENSMUST00000167763.2 NR_038053 uc029skn.1 uc029skn.2 uc029skn.3 uc029skn.4 uc029skn.1 uc029skn.2 uc029skn.3 uc029skn.4 
ENSMUST00000167777.3 Gm8378 ENSMUST00000167777.3 Gm8378 (from geneSymbol) AK158157 ENSMUST00000167777.1 ENSMUST00000167777.2 uc007oku.1 uc007oku.2 uc007oku.1 uc007oku.2 
ENSMUST00000167790.3 Sct ENSMUST00000167790.3 secretin, transcript variant 2 (from RefSeq NM_011328.4) ENSMUST00000167790.1 ENSMUST00000167790.2 NM_011328 Q3UKU8 Q3UKU8_MOUSE Sct uc009kkl.1 uc009kkl.2 uc009kkl.3 uc009kkl.4 This gene encodes the precursor of a gastrointestinal peptide hormone of the secretin-glucagon family. The encoded protein is secreted as a prohormone that undergoes proteolytic processing to generate a mature peptide hormone. The mature peptide regulates secretion of gastric acid, biocarbonate ions from pancreatic and biliary duct epithelia and water homeostasis in the gastrointestinal system. Mice lacking the encoded protein display decreased survival of neuroprogenitor cells during early postnatal period and impaired long-term potentiation and spatial learning in adulthood. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may be processed in a similar manner to generate the mature peptide hormone. [provided by RefSeq, Jul 2015]. Secreted Belongs to the glucagon family. hormone activity extracellular region signal transduction uc009kkl.1 uc009kkl.2 uc009kkl.3 uc009kkl.4 
ENSMUST00000167797.8 Phykpl ENSMUST00000167797.8 5-phosphohydroxy-L-lysine phospholyase, transcript variant 3 (from RefSeq NR_168564.1) AT2L2_MOUSE Agxt2l2 ENSMUST00000167797.1 ENSMUST00000167797.2 ENSMUST00000167797.3 ENSMUST00000167797.4 ENSMUST00000167797.5 ENSMUST00000167797.6 ENSMUST00000167797.7 NR_168564 Q3TUU9 Q8BG04 Q8R1K4 uc007ity.1 uc007ity.2 uc007ity.3 This gene overlaps in a tail-to-tail orientation the gene encoding heterogeneous nuclear ribonucleoprotein A/B. The terminal exon of this gene is interspersed with exons of heterogeneous nuclear ribonucleoprotein A/B. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: SRR6238556.285570.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## Catalyzes the pyridoxal-phosphate-dependent breakdown of 5- phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde. Reaction=(5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate; Xref=Rhea:RHEA:34091, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:43474, ChEBI:CHEBI:57882, ChEBI:CHEBI:58321; EC=4.2.3.134; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Homotetramer. Mitochondrion Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R1K4-1; Sequence=Displayed; Name=2; IsoId=Q8R1K4-2; Sequence=VSP_025588; Name=3; IsoId=Q8R1K4-3; Sequence=VSP_025586, VSP_025587; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Does not seem to possess aminotransferase activity. catalytic activity mitochondrion biological_process transaminase activity lyase activity pyridoxal phosphate binding identical protein binding uc007ity.1 uc007ity.2 uc007ity.3 
ENSMUST00000167816.8 Wdr25 ENSMUST00000167816.8 WD repeat domain 25 (from RefSeq NM_177602.3) E9Q349 ENSMUST00000167816.1 ENSMUST00000167816.2 ENSMUST00000167816.3 ENSMUST00000167816.4 ENSMUST00000167816.5 ENSMUST00000167816.6 ENSMUST00000167816.7 NM_177602 Q8C4T7 WDR25_MOUSE uc011yrx.1 uc011yrx.2 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q349-1; Sequence=Displayed; Name=2; IsoId=E9Q349-2; Sequence=VSP_042397, VSP_042398; molecular_function cellular_component biological_process uc011yrx.1 uc011yrx.2 
ENSMUST00000167824.3 Rab3c ENSMUST00000167824.3 RAB3C, member RAS oncogene family, transcript variant 1 (from RefSeq NM_023852.5) ENSMUST00000167824.1 ENSMUST00000167824.2 NM_023852 Q542T7 Q542T7_MOUSE Rab3C Rab3c uc007rvo.1 uc007rvo.2 uc007rvo.3 uc007rvo.4 uc007rvo.5 Protein transport. Probably involved in vesicular traffic. Cell membrane ipid-anchor ; Cytoplasmic side mbrane ; Lipid-anchor ; Cytoplasmic side Belongs to the small GTPase superfamily. Rab family. GTPase activity GTP binding cytosol antigen processing and presentation myosin V binding vesicle perinuclear region of cytoplasm anchored component of synaptic vesicle membrane uc007rvo.1 uc007rvo.2 uc007rvo.3 uc007rvo.4 uc007rvo.5 
ENSMUST00000167830.3 Vmn2r75 ENSMUST00000167830.3 vomeronasal 2, receptor 75 (from RefSeq NM_001102578.1) ENSMUST00000167830.1 ENSMUST00000167830.2 G5E8Z7 G5E8Z7_MOUSE NM_001102578 Vmn2r75 uc009ven.1 uc009ven.2 uc009ven.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009ven.1 uc009ven.2 uc009ven.3 
ENSMUST00000167843.2 ENSMUSG00000121635 ENSMUST00000167843.2 ENSMUSG00000121635 (from geneSymbol) AK166771 ENSMUST00000167843.1 uc288fgf.1 uc288fgf.2 uc288fgf.1 uc288fgf.2 
ENSMUST00000167861.8 Cuedc2 ENSMUST00000167861.8 CUE domain containing 2, transcript variant 2 (from RefSeq NM_024192.2) CUED2_MOUSE ENSMUST00000167861.1 ENSMUST00000167861.2 ENSMUST00000167861.3 ENSMUST00000167861.4 ENSMUST00000167861.5 ENSMUST00000167861.6 ENSMUST00000167861.7 NM_024192 Q99LC1 Q9CXX9 uc012bmu.1 uc012bmu.2 Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation. Interacts with PGR and ESR1. Cytoplasm Nucleus The CUE domain mediates interaction with PGR and ESR1. Belongs to the CUEDC2 family. molecular_function nucleus nucleoplasm cytoplasm cytosol negative regulation of macrophage cytokine production nuclear membrane negative regulation of cytokine production involved in inflammatory response uc012bmu.1 uc012bmu.2 
ENSMUST00000167866.2 Idh3a ENSMUST00000167866.2 isocitrate dehydrogenase 3 (NAD+) alpha (from RefSeq NM_029573.2) ENSMUST00000167866.1 IDH3A_MOUSE Idh3a NM_029573 Q3UAM8 Q8C8A1 Q9D1L1 Q9D6R2 uc009prg.1 uc009prg.2 uc009prg.3 Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Reaction=D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH; Xref=Rhea:RHEA:23632, ChEBI:CHEBI:15562, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.41; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23633; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Divalent metal cations; Mn(2+) or Mg(2+). Activity higher in presence of Mn(2+) than of Mg(2+). Binds 1 Mg(2+) or Mn(2+) ion per subunit. ; The heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits can be allosterically activated by citrate (CIT) or/and ADP, and the two activators can act independently or synergistically. The heterodimer composed of IDH3A and IDH3B subunits cannot be allosterically regulated and the allosteric regulation of the heterotetramer is through the IDH3G subunit and not the IDH3B subunit. The IDH3G subunit contains the allosteric site which consists of a CIT- binding site and an ADP-binding site, and the binding of CIT and ADP causes conformational changes at the allosteric site which are transmitted to the active site in the catalytic subunit (IDH3A) through a cascade of conformational changes at the heterodimer interface, leading to stabilization of the isocitrate-binding at the active site and thus activation of the enzyme. ATP can activate the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits at low concentrations but inhibits their activities at high concentrations, whereas ATP exhibits only inhibitory effect on the heterodimer composed of IDH3A and IDH3B subunits. Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D6R2-1; Sequence=Displayed; Name=2; IsoId=Q9D6R2-2; Sequence=VSP_014517; IDH3A-null homozygous mice do not survive early embryogenesis (PubMed:30478029). Compound heterozygous mice for the IDH3A-null allele and mutant p.E229K are viable and exhibit rapid retinal degeneration (PubMed:30478029). Belongs to the isocitrate and isopropylmalate dehydrogenases family. magnesium ion binding isocitrate dehydrogenase (NAD+) activity mitochondrion tricarboxylic acid cycle isocitrate metabolic process 2-oxoglutarate metabolic process NADH metabolic process oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor myelin sheath metal ion binding NAD binding oxidation-reduction process uc009prg.1 uc009prg.2 uc009prg.3 
ENSMUST00000167871.2 Vmn1r159 ENSMUST00000167871.2 vomeronasal 1 receptor 159 (from RefSeq NM_001166758.1) ENSMUST00000167871.1 K7N701 K7N701_MOUSE NM_001166758 Vmn1r159 uc012fek.1 uc012fek.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fek.1 uc012fek.2 
ENSMUST00000167899.5 Gm17484 ENSMUST00000167899.5 predicted gene, 17484 (from RefSeq NR_154462.1) ENSMUST00000167899.1 ENSMUST00000167899.2 ENSMUST00000167899.3 ENSMUST00000167899.4 NR_154462 uc009lgx.1 uc009lgx.2 uc009lgx.3 uc009lgx.4 uc009lgx.5 uc009lgx.1 uc009lgx.2 uc009lgx.3 uc009lgx.4 uc009lgx.5 
ENSMUST00000167902.2 Gm3182 ENSMUST00000167902.2 Gm3182 (from geneSymbol) ENSMUST00000167902.1 Gm3182 Gm7876 K7N6T8 K7N6T8_MOUSE uc288qju.1 uc288qju.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qju.1 uc288qju.2 
ENSMUST00000167908.2 Gm17019 ENSMUST00000167908.2 predicted gene 17019 (from RefSeq NM_182957.1) ENSMUST00000167908.1 Gm17019 K7N6W5 K7N6W5_MOUSE NM_182957 uc008wmq.1 uc008wmq.2 uc008wmq.3 uc008wmq.4 uc008wmq.1 uc008wmq.2 uc008wmq.3 uc008wmq.4 
ENSMUST00000167913.8 Gm3476 ENSMUST00000167913.8 Gm3476 (from geneSymbol) ENSMUST00000167913.1 ENSMUST00000167913.2 ENSMUST00000167913.3 ENSMUST00000167913.4 ENSMUST00000167913.5 ENSMUST00000167913.6 ENSMUST00000167913.7 Gm3476 K7N6V0 K7N6V0_MOUSE uc288qnx.1 uc288qnx.2 molecular_function cellular_component biological_process uc288qnx.1 uc288qnx.2 
ENSMUST00000167914.2 Gm26965 ENSMUST00000167914.2 Gm26965 (from geneSymbol) BC061200 ENSMUST00000167914.1 Gm26965 M0QWH4 M0QWH4_MOUSE uc288ofl.1 uc288ofl.2 nucleic acid binding regulation of transcription, DNA-templated uc288ofl.1 uc288ofl.2 
ENSMUST00000167915.3 Chst3 ENSMUST00000167915.3 carbohydrate sulfotransferase 3, transcript variant 1 (from RefSeq NM_016803.4) C6st CHST3_MOUSE ENSMUST00000167915.1 ENSMUST00000167915.2 Gst0 NM_016803 O88199 Q794I5 uc287rld.1 uc287rld.2 uc287rld.3 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin (PubMed:9597547, PubMed:11696535). Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices (PubMed:9597547). Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan (PubMed:11696535). Can also catalyze the sulfation of the Gal residues in sialyl N- acetyllactosamine (sialyl LacNAc) oligosaccharides (By similarity). May play a role in the maintenance of naive T-lymphocytes in the spleen (PubMed:11696535). Reaction=n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+); Xref=Rhea:RHEA:11108, Rhea:RHEA-COMP:9827, Rhea:RHEA-COMP:9828, ChEBI:CHEBI:15378, ChEBI:CHEBI:57652, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:62065; EC=2.8.2.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11109; Evidence=; Reaction=3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'- bisphosphate + keratan 6'-sulfate.; EC=2.8.2.21; Evidence=; Golgi apparatus membrane ; Single- pass type II membrane protein Widely expressed. Highly expressed in spleen, lung, eye and stomach. Constitutively expressed at low level during the mid- to late-gestation period. Expressed in the brain in a temporally controlled manner: peaks at 2 weeks after birth in the cerebellum, but at 3 weeks in the cerebrum. Localizes to stromal cells in the bone marrow, and stromal cells in the marginal zone and red pulp of the spleen, but the sense probe did not. N-glycosylated. Mice are viable through adulthood. In their spleen the level of chondroitin 6'-sulfate is almost undetectable. In the spleen of 5-6 week-old mice, the number of CD62L(+)CD44(low) T- lymphocytes corresponding to naive T-lymphocytes is significantly decreased, whereas those in other secondary lymphoid organs are unchanged. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. Golgi membrane N-acetylglucosamine 6-O-sulfotransferase activity Golgi apparatus trans-Golgi network carbohydrate metabolic process N-acetylglucosamine metabolic process sulfur compound metabolic process sulfotransferase activity chondroitin 6-sulfotransferase activity membrane integral component of membrane transferase activity chondroitin sulfate biosynthetic process T cell homeostasis proteoglycan sulfotransferase activity positive regulation of cellular component movement uc287rld.1 uc287rld.2 uc287rld.3 
ENSMUST00000167923.8 Gm3696 ENSMUST00000167923.8 predicted gene 3696, transcript variant 3 (from RefSeq NM_001368230.1) ENSMUST00000167923.1 ENSMUST00000167923.2 ENSMUST00000167923.3 ENSMUST00000167923.4 ENSMUST00000167923.5 ENSMUST00000167923.6 ENSMUST00000167923.7 Gm3696 K7N751 K7N751_MOUSE NM_001368230 uc288qpt.1 uc288qpt.2 molecular_function cellular_component biological_process uc288qpt.1 uc288qpt.2 
ENSMUST00000167935.10 Acsm2 ENSMUST00000167935.10 acyl-CoA synthetase medium-chain family member 2, transcript variant 3 (from RefSeq NM_146197.4) ACSM2_MOUSE ENSMUST00000167935.1 ENSMUST00000167935.2 ENSMUST00000167935.3 ENSMUST00000167935.4 ENSMUST00000167935.5 ENSMUST00000167935.6 ENSMUST00000167935.7 ENSMUST00000167935.8 ENSMUST00000167935.9 NM_146197 Q3TNC6 Q3US47 Q8K0L3 Q8R1L3 Q96LX4 uc009jlh.1 uc009jlh.2 uc009jlh.3 uc009jlh.4 Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity). Reaction=a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:48340, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:59558, ChEBI:CHEBI:90546, ChEBI:CHEBI:456215; EC=6.2.1.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48341; Evidence=; Reaction=ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate; Xref=Rhea:RHEA:10132, ChEBI:CHEBI:16150, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57369, ChEBI:CHEBI:456215; EC=6.2.1.25; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10133; Evidence=; Reaction=ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA; Xref=Rhea:RHEA:43740, ChEBI:CHEBI:17120, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:62620, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43741; Evidence=; Reaction=ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate; Xref=Rhea:RHEA:46172, ChEBI:CHEBI:17968, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46173; Evidence=; Reaction=ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA; Xref=Rhea:RHEA:33631, ChEBI:CHEBI:25646, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33632; Evidence=; Reaction=ATP + CoA + decanoate = AMP + decanoyl-CoA + diphosphate; Xref=Rhea:RHEA:33627, ChEBI:CHEBI:27689, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33628; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Monomer. Mitochondrion Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K0L3-1; Sequence=Displayed; Name=2; IsoId=Q8K0L3-2; Sequence=VSP_028393; Name=3; IsoId=Q8K0L3-3; Sequence=VSP_028394; Belongs to the ATP-dependent AMP-binding enzyme family. nucleotide binding catalytic activity acyl-CoA ligase activity fatty-acyl-CoA synthase activity ATP binding mitochondrion mitochondrial matrix lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process acyl-CoA metabolic process fatty acid ligase activity ligase activity benzoate-CoA ligase activity medium-chain fatty-acyl-CoA metabolic process metal ion binding butyrate-CoA ligase activity uc009jlh.1 uc009jlh.2 uc009jlh.3 uc009jlh.4 
ENSMUST00000167944.8 Pcdh19 ENSMUST00000167944.8 protocadherin 19, transcript variant 2 (from RefSeq NM_001105246.1) E9Q5E1 E9Q5E1_MOUSE ENSMUST00000167944.1 ENSMUST00000167944.2 ENSMUST00000167944.3 ENSMUST00000167944.4 ENSMUST00000167944.5 ENSMUST00000167944.6 ENSMUST00000167944.7 NM_001105246 Pcdh19 uc009uex.1 uc009uex.2 uc009uex.3 uc009uex.4 uc009uex.5 calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules brain development membrane integral component of membrane uc009uex.1 uc009uex.2 uc009uex.3 uc009uex.4 uc009uex.5 
ENSMUST00000167951.3 Prr23a3 ENSMUST00000167951.3 proline rich 23A, member 3 (from RefSeq NM_028033.1) ENSMUST00000167951.1 ENSMUST00000167951.2 NM_028033 P23A3_MOUSE Prr23a3 Q9CWP9 uc012gyw.1 uc012gyw.2 uc012gyw.3 Belongs to the PRR23 family. molecular_function cellular_component biological_process uc012gyw.1 uc012gyw.2 uc012gyw.3 
ENSMUST00000167959.2 Syce3 ENSMUST00000167959.2 synaptonemal complex central element protein 3, transcript variant 1 (from RefSeq NM_001162880.1) E7D6R1 E7D6R1_MOUSE ENSMUST00000167959.1 NM_001162880 Syce3 uc007xgp.1 uc007xgp.2 uc007xgp.3 synaptonemal complex assembly reciprocal meiotic recombination spermatogenesis uc007xgp.1 uc007xgp.2 uc007xgp.3 
ENSMUST00000167965.8 Tgfb1i1 ENSMUST00000167965.8 transforming growth factor beta 1 induced transcript 1, transcript variant 6 (from RefSeq NM_001417329.1) Ara55 ENSMUST00000167965.1 ENSMUST00000167965.2 ENSMUST00000167965.3 ENSMUST00000167965.4 ENSMUST00000167965.5 ENSMUST00000167965.6 ENSMUST00000167965.7 NM_001417329 Q3YBY7 Q3YBY8 Q3YBZ0 Q3YBZ1 Q3YBZ3 Q3YBZ4 Q3YBZ5 Q3YBZ6 Q62219 TGFI1_MOUSE uc009jyq.1 uc009jyq.2 uc009jyq.3 uc009jyq.4 Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. Homooligomer (PubMed:16737959). Interacts with PPARG (PubMed:15687259). Interacts with TRAF4 (By similarity). Interacts with CRIP2 (PubMed:15713747). Interacts with HSPB1 (PubMed:11546764). Interacts with ILK (PubMed:16737959). Interacts with LIMS1 and LIMS2 (PubMed:16737959). Interacts with NCK2 (PubMed:10330411). Interacts with NUDT16L1 (PubMed:11805099). Interacts with PAK (PubMed:10330411). Interacts with PTPN12 (PubMed:10092676). Interacts with TCF3 (PubMed:16291758). Interacts with TCF7L2 (PubMed:16291758). Interacts with VCL (PubMed:9858471). Interacts (via LD motif 3) with GIT1 (PubMed:12153727). Also interacts with GIT2 (PubMed:10330411). Forms a complex with ARHGEF7 (PubMed:10330411, PubMed:12153727). Interacts with AR/androgen receptor in a ligand-dependent manner (PubMed:11779876). Interacts with CSK (PubMed:9858471, PubMed:17233630). Interacts with PTK2/FAK1 and PTK2B/PYK2 (PubMed:9422762, PubMed:9756887, PubMed:10330411, PubMed:9858471, PubMed:10649439). Interacts with SLC6A3 (PubMed:12177201). Interacts with SLC6A4 (By similarity). Interacts with NR3C1 (PubMed:10848625). Interacts with SMAD3 (PubMed:14755691). Interacts with MAPK15 (PubMed:16624805). Interacts with SRC (By similarity). Interacts with LYN (By similarity). Interacts with talin (By similarity). Interacts (via LIM zinc-binding domain 2) with CBLC (via RING-type zinc finger); the interaction is direct and enhances CBLC E3 ubiquitin-protein ligase activity (By similarity). Interacts with PARVA (PubMed:11134073). Interacts with PXN (By similarity). Q62219; Q8C115: Plekhh2; NbExp=3; IntAct=EBI-642844, EBI-6512409; Q62219; Q05397: PTK2; Xeno; NbExp=3; IntAct=EBI-642844, EBI-702142; Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton, colocalizes with stress fibers. Event=Alternative splicing; Named isoforms=10; Name=1; Synonyms=Alpha; IsoId=Q62219-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q62219-2; Sequence=VSP_026191; Name=3; Synonyms=Alpha-B; IsoId=Q62219-3; Sequence=VSP_026190; Name=4; Synonyms=Alpha-E; IsoId=Q62219-4; Sequence=VSP_026193; Name=5; Synonyms=Beta-G; IsoId=Q62219-5; Sequence=VSP_026189, VSP_026192; Name=6; Synonyms=Alpha-C; IsoId=Q62219-6; Sequence=VSP_039813, VSP_039814; Name=7; Synonyms=Beta-B, Beta-D; IsoId=Q62219-7; Sequence=VSP_026184; Name=8; Synonyms=Beta-C; IsoId=Q62219-8; Sequence=VSP_026191, VSP_039813, VSP_039814; Name=9; Synonyms=Beta-E, Beta-F; IsoId=Q62219-9; Sequence=VSP_026188, VSP_026194; Name=10; Synonyms=Alpha-D; IsoId=Q62219-10; Sequence=VSP_026185, VSP_026197; Ubiquitously expressed. Higher expression is detected in lung and spleen. Expression decreases during pregnancy in mammary glands. Expressed in all brain areas, with higher levels in cerebellum, prefrontal cortex and hypothalamus. Expressed in smooth muscle, myoepithelial cells and platelets (at protein level). Preferentially expressed in mesenchymal versus epithelial cells (at protein level). First detected in the developing heart tube at 8.0 dpc and then in cardiac, skeletal and smooth muscle during early stages of development. Highly expressed in differentiating gut epithelial cells. Up-regulated during epithelial to mesenchymal transformation. Up-regulated by TGFB1 and hydrogen peroxide. The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc- binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12. The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal. Phosphorylated by gonadotropin-releasing hormone-activated SRC. [Isoform 1]: Transcripts of the alpha group are more abundantly expressed. [Isoform 3]: Transcripts of the alpha group are more abundantly expressed. [Isoform 4]: Transcripts of the alpha group are more abundantly expressed. [Isoform 6]: Transcripts of the alpha group are more abundantly expressed. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. [Isoform 8]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. [Isoform 10]: Transcripts of the alpha group are more abundantly expressed. Belongs to the paxillin family. Sequence=AAH02049.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAZ82195.1; Type=Frameshift; Evidence=; Sequence=AAZ82200.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; Sequence=BAE33707.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE34493.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; transcription cofactor activity transcription coactivator activity protein binding nucleus cytoplasm cytosol cytoskeleton plasma membrane focal adhesion transforming growth factor beta receptor signaling pathway response to heat positive regulation of epithelial to mesenchymal transition Wnt signaling pathway morphogenesis of embryonic epithelium nuclear matrix cell junction cell differentiation positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway ubiquitin-dependent SMAD protein catabolic process epithelial cell differentiation substrate adhesion-dependent cell spreading endothelial cell migration cell fate commitment negative regulation of fat cell differentiation positive regulation of transcription, DNA-templated metal ion binding Roundabout binding androgen receptor binding I-SMAD binding uc009jyq.1 uc009jyq.2 uc009jyq.3 uc009jyq.4 
ENSMUST00000167974.2 Or10u4 ENSMUST00000167974.2 olfactory receptor family 10 subfamily U member 4 (from RefSeq NM_001165944.1) ENSMUST00000167974.1 K7N727 K7N727_MOUSE NM_001165944 Olfr819 Or10u4 uc011xqm.1 uc011xqm.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Sep 2009]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc011xqm.1 uc011xqm.2 
ENSMUST00000167976.4 Vmn2r83 ENSMUST00000167976.4 vomeronasal 2, receptor 83 (from RefSeq NM_001104537.1) E9Q0G7 E9Q0G7_MOUSE ENSMUST00000167976.1 ENSMUST00000167976.2 ENSMUST00000167976.3 NM_001104537 Vmn2r83 uc009vab.1 uc009vab.2 uc009vab.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane neuron differentiation G-protein coupled olfactory receptor activity signaling receptor activity detection of chemical stimulus involved in sensory perception of smell uc009vab.1 uc009vab.2 uc009vab.3 
ENSMUST00000167981.3 Zfp999 ENSMUST00000167981.3 Zfp999 (from geneSymbol) AB010371 ENSMUST00000167981.1 ENSMUST00000167981.2 F7AIG4 F7AIG4_MOUSE Gm10772 Gm17353 Zfp999 uc288oar.1 uc288oar.2 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding uc288oar.1 uc288oar.2 
ENSMUST00000167994.10 Prdm9 ENSMUST00000167994.10 PR domain containing 9, transcript variant 1 (from RefSeq NM_144809.3) B8JJZ8 ENSMUST00000167994.1 ENSMUST00000167994.2 ENSMUST00000167994.3 ENSMUST00000167994.4 ENSMUST00000167994.5 ENSMUST00000167994.6 ENSMUST00000167994.7 ENSMUST00000167994.8 ENSMUST00000167994.9 Hst1 Meisetz NM_144809 PRDM9_MOUSE Prdm9 Q0D2N4 Q96EQ9 uc289hha.1 uc289hha.2 Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:16292313, PubMed:24095733, PubMed:27362481, PubMed:24785241, PubMed:29478809). Can also methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24785241, PubMed:27362481). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (PubMed:24785241, PubMed:27362481). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:22028627, PubMed:27362481, PubMed:29478809). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (PubMed:16292313, PubMed:29478809). During meiotic progression hotspot- bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema (PubMed:27932493). EWSR1 joins PRDM9 with the chromosomal axis through REC8 (PubMed:27932493). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (PubMed:25894966, PubMed:16292313). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (PubMed:16292313). In addition performs automethylation (PubMed:28126738). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (PubMed:27362481). Reaction=L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:51736, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13053, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51737; Evidence=; Reaction=N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54200, Rhea:RHEA-COMP:13826, Rhea:RHEA- COMP:13827, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961, ChEBI:CHEBI:61976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54201; Evidence=; Reaction=L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60260, Rhea:RHEA-COMP:15537, Rhea:RHEA- COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.354; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60261; Evidence= Reaction=L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60324, Rhea:RHEA-COMP:9785, Rhea:RHEA- COMP:15536, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.359; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60325; Evidence=; Reaction=L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60276, Rhea:RHEA-COMP:15538, Rhea:RHEA- COMP:15546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.355; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60277; Evidence=; Reaction=L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60344, Rhea:RHEA-COMP:15554, Rhea:RHEA-COMP:15555, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.361; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60345; Evidence=; Reaction=N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60348, Rhea:RHEA-COMP:15555, Rhea:RHEA- COMP:15556, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; EC=2.1.1.362; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60349; Evidence=; Kinetic parameters: KM=0.17 uM for histone octamer ; KM=0.19 uM for H3 protein ; KM=3.21 uM for H3 peptide 1-21 ; KM=5.47 uM for H4 peptide 1-36 ; KM=22.29 uM for S-adenosyl-L-methionine (with histone octamer as substrate) ; KM=19.01 uM for S-adenosyl-L-methionine (with H3 protein as substrate) ; KM=8.23 uM for S-adenosyl-L-methionine (with H3 peptide 1-21 as substrate) ; KM=81.66 uM for S-adenosyl-L-methionine (with H4 peptide 1-36 as substrate) ; KM=34.7 uM for automethylation ; KM=8.23 uM for H3 peptide ; Homodimer (PubMed:24095733). Interacts with EHMT2 and CDYL; interaction only takes place when PRDM9 is bound to hotspot DNA (PubMed:27932493). Interacts with CXXC1; this interaction does not link PRDM9-activated recombination hotspot sites with DSB machinery and is not required for the hotspot recognition pathway (PubMed:27932493, PubMed:30365547). Forms a complex with EWSR1, REC8, SYCP3 and SYCP1; complex formation is dependent of phosphorylated form of REC8 and requires PRDM9 bound to hotspot DNA; EWSR1 joins PRDM9 with the chromosomal axis through REC8 (PubMed:27932493). Nucleus romosome Note=Localizes in nuclei of pre- leptotene, leptotene, and early to mid-zygotene spermatocytes. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Meisetz; IsoId=Q96EQ9-1; Sequence=Displayed; Name=2; Synonyms=Meisetz-S1; IsoId=Q96EQ9-2; Sequence=VSP_036376, VSP_036377; Name=3; Synonyms=Meisetz-S2; IsoId=Q96EQ9-3; Sequence=VSP_036375, VSP_036378; Name=4; IsoId=Q96EQ9-4; Sequence=VSP_036374, VSP_036376, VSP_036377; Specifically expressed in germ cells entering meiotic prophase in female fetal gonads and in postnatal testis (PubMed:16292313). Expressed in early meiotic prophase (PubMed:27932493). Specifically expressed during meiotic prophase. Transiently increases in female gonads from 13.5 dpc to 16.5 dpc, the time during which meiosis proceeds from pre-meiotic replication to pachytene stages. Its expression is barely detectable in fetal male gonads. In adults, it is expressed in testis, but not in any other tissue tested. Abundance increases from 10 d post partum (dpp) to 18 dpp, during which time the first wave of spermatogenesis proceeds synchronously from pre-leptotene to pachytene stages. The C2H2-type zinc fingers determine the hotspot localization through its binding to specific DNA sequences (PubMed:22028627, PubMed:29478809). Variations in their sequence affect affinity towards DNA-binding motif (PubMed:22028627, PubMed:29478809). Mono-methylated; automethylated (PubMed:28126738). Tri-methylated; automethylated (PubMed:28126738). Mono-methylation is predominant; automethylation is lower and slower than H3 peptide methylation and is in a highest S-adenosyl-L-methionine concentration-dependent (PubMed:28126738). There are two major sites for automethylation at Lys-368 and Lys-374 (PubMed:28126738). Lysines can be simultaneously methylated, such as Lys-368(me3)/Lys-372(me1), Lys-368(me1)/Lys- 374(me1) and Lys-368(me1)/Lys-372(me1)/Lys-374(me1) (PubMed:28126738). Automethylation is an intramolecular (cis) process (PubMed:28126738). Several alleles exist depending on both the number of zinc finger C2H2 type domains and their identity (PubMed:22028627). Each allele binds to a specific hotspot set (PubMed:29478809). Both polymorphisms in the zinc finger C2H2 type domains and in DNA target sequence control recombination at hotspot (PubMed:22028627). The affinity of each allele for its DNA-binding site can vary histone methyltransferase activity (PubMed:29478809). Knockout homozygous mice are sterile in both sexes. Represents a speciation gene in mus genus. Prdm9 is one of several genes responsible for hybrid sterility between M.musculus and house mouse (PubMed:19074312). Hybrid sterility is defined as a situation where parental forms, each fertile inter se, produce infertile offspring (PubMed:19074312). Intersubspecific hybrids of house mouse display spermatogenic failures that are due to variations in the Prdm9 gene (PubMed:19074312). Belongs to the class V-like SAM-binding methyltransferase superfamily. Firstly described as not catalyzing the monomethylation of unmethylated H3 peptide (PubMed:16292313). However other in vitro experiments described that can also methylate unmodified 'Lys-4' of histone H3 (PubMed:24095733, PubMed:24785241, PubMed:27362481). Sequence=AAH49903.1; Type=Erroneous initiation; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding nucleic acid binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm chromosome meiotic gene conversion chromatin organization regulation of transcription, DNA-templated spermatogenesis methyltransferase activity recombination hotspot binding positive regulation of reciprocal meiotic recombination histone methylation nucleosome positioning transferase activity histone-lysine N-methyltransferase activity chromatin DNA binding methylation histone lysine methylation histone methyltransferase activity (H3-K4 specific) protein homodimerization activity negative regulation of apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding histone H3-K4 dimethylation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding histone methyltransferase activity (H3-K36 specific) meiotic cell cycle histone H3-K9 methylation positive regulation of meiosis I histone H3-K4 trimethylation histone H3-K36 trimethylation histone H3-K36 dimethylation histone H3-K4 monomethylation positive regulation of histone H3-K4 trimethylation positive regulation of histone H3-K36 trimethylation uc289hha.1 uc289hha.2 
ENSMUST00000168000.2 Gm17173 ENSMUST00000168000.2 Gm17173 (from geneSymbol) AK144143 ENSMUST00000168000.1 uc007tgc.1 uc007tgc.2 uc007tgc.1 uc007tgc.2 
ENSMUST00000168003.9 Cyp26b1 ENSMUST00000168003.9 cytochrome P450, family 26, subfamily b, polypeptide 1, transcript variant 2 (from RefSeq NM_001177713.1) CP26B_MOUSE ENSMUST00000168003.1 ENSMUST00000168003.2 ENSMUST00000168003.3 ENSMUST00000168003.4 ENSMUST00000168003.5 ENSMUST00000168003.6 ENSMUST00000168003.7 ENSMUST00000168003.8 NM_001177713 Q3TM12 Q811W2 uc057lqs.1 uc057lqs.2 uc057lqs.3 A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (Probable). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13- dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (By similarity). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (Probable). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (By similarity). Involved in the convertion of atRA to all- trans-4-oxo-RA (Probable). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all- trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy- DRA (Probable). Shows preference for the following substrates: atRA > 9-cis-RA > 13-cis-RA (By similarity). Plays a central role in germ cell development: acts by degrading RAs in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis (PubMed:16461896, PubMed:16574820, PubMed:19838304). Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry (PubMed:16574820, PubMed:16461896, PubMed:19838304). Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (PubMed:22019272). Essential for postnatal survival (PubMed:16461896, PubMed:16574820, PubMed:19838304). Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo. Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51984, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134178; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51985; Evidence=; Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:55856, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:139258; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55857; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein In the embryonic male gonad, expressed in somatic cells as early as 11.5 dpc and persist throughout development. Expression is detected in peritubular myoepithelial cells in the postnatal testis, while expression is absent in developing and adult ovaries. Germ cells enter meiosis precociously in embryonic testes, due to strong-up-regulation of Stra8. Belongs to the cytochrome P450 family. C-22 sterol desaturase activity cell fate determination establishment of T cell polarity kidney development retinoic acid binding monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane ergosterol biosynthetic process xenobiotic metabolic process inflammatory response male meiosis spermatogenesis retinoic acid 4-hydroxylase activity proximal/distal pattern formation positive regulation of gene expression membrane sterol metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen heme binding embryonic limb morphogenesis organelle membrane response to retinoic acid response to vitamin A retinoic acid catabolic process retinoic acid metabolic process intracellular membrane-bounded organelle tongue morphogenesis regulation of T cell differentiation metal ion binding retinoic acid receptor signaling pathway regulation of retinoic acid receptor signaling pathway negative regulation of retinoic acid receptor signaling pathway oxidation-reduction process bone morphogenesis establishment of skin barrier cornification cellular response to retinoic acid positive regulation of tongue muscle cell differentiation uc057lqs.1 uc057lqs.2 uc057lqs.3 
ENSMUST00000168005.8 Dennd2b ENSMUST00000168005.8 DENN domain containing 2B, transcript variant 2 (from RefSeq NM_029811.2) DEN2B_MOUSE Denn2b ENSMUST00000168005.1 ENSMUST00000168005.2 ENSMUST00000168005.3 ENSMUST00000168005.4 ENSMUST00000168005.5 ENSMUST00000168005.6 ENSMUST00000168005.7 NM_029811 Q05BD9 Q78H54 Q8K2P3 Q924W7 Q924W8 St5 uc009jdv.1 uc009jdv.2 [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane. [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. [Isoform 3]: May block ERK2 activation stimulated by ABL1. May alter cell morphology and cell growth. Interacts with ITSN1 and GRB2. Isoform 1 interacts with the SH3 domain of ABL1. Cytoplasm, cell cortex Cell membrane Recycling endosome Note=Colocalizes with RAB13 and ITSN1 at cytoplasmic vesicles that are most likely recycling endosomes. Colocalizes with the cortical actin cytoskeleton. Event=Alternative promoter usage, Alternative splicing; Named isoforms=3; Name=1; IsoId=Q924W7-1; Sequence=Displayed; Name=2; IsoId=Q924W7-2; Sequence=VSP_019990; Name=3; IsoId=Q924W7-3; Sequence=VSP_019989; Phosphorylated. Phosphorylation decreases ITSN1 binding. [Isoform 1]: May be produced by alternative promoter usage. Alternative promoter usage has been proven in human. [Isoform 2]: Produced by alternative splicing of isoform 1. [Isoform 3]: May be produced by alternative promoter usage. Alternative promoter usage has been proven in human. Sequence=AAH32266.1; Type=Erroneous initiation; Evidence=; guanyl-nucleotide exchange factor activity cellular_component cytoplasm endosome plasma membrane cell cortex membrane Rab guanyl-nucleotide exchange factor activity recycling endosome positive regulation of ERK1 and ERK2 cascade uc009jdv.1 uc009jdv.2 
ENSMUST00000168015.8 Mov10 ENSMUST00000168015.8 Mov10 RISC complex RNA helicase, transcript variant 2 (from RefSeq NM_008619.3) ENSMUST00000168015.1 ENSMUST00000168015.2 ENSMUST00000168015.3 ENSMUST00000168015.4 ENSMUST00000168015.5 ENSMUST00000168015.6 ENSMUST00000168015.7 Gb110 MOV10_MOUSE NM_008619 P23249 Q9DC64 uc008qun.1 uc008qun.2 uc008qun.3 uc008qun.4 uc008qun.5 uc008qun.6 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation. Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7 (By similarity). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (PubMed:28662698). May function as a messenger ribonucleoprotein (mRNP) clearance factor (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Interacts with DICER1, AGO2, TARBP2, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). Interacts with APOBEC3G in an RNA-dependent manner. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:28662698) (By similarity). Interacts with both protein products of LIRE1, ORF1p and ORF2p (PubMed:28662698). Interacts with TUT4 and, to a lesser extent, TUT7; the interactions are RNA-dependent. Interacts with AGO2, TNRC6B and UPF1; the interactions are direct and RNA- dependent. Interacts with FMR1; this interaction is direct, occurs in an RNA-dependent manner on polysomes and induces association of MOV10 with RNAs (By similarity). Interacts with SHFL; the interaction increases in presence of RNA (By similarity). Interacts with DHX34; the interaction is RNA-independent (By similarity). Interacts with RBM46 (PubMed:36001654). Cytoplasm, P-body Nucleus Cytoplasm Cytoplasm, Cytoplasmic ribonucleoprotein granule Cytoplasm, Stress granule Note=In young mouse (P2) neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (PubMed:28662698). Co-enriched in cytoplasmic foci with TUT4 (By similarity). As early as embryonic day 18, there is a higher level of expression in the whole brain compared to adults. Expression continues to rise at birth (P0) and remains elevated over adult levels until P10-P14, when it begins to decline (PubMed:28662698). Highly expressed throughout the P1 brain, including the cortex, hippocampus, cerebellum, midbrain, and hindbrain, there is very little expression in the adult brain except in the hippocampus (PubMed:28662698). Ubiquitinated by the DCX(DCAF12) complex that specifically recognizes the glutamate-leucine (Glu-Leu) degron at the C-terminus, leading to its degradation. Knockout leads to early embryonic lethality. Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily. nucleotide binding P-body RNA binding RNA helicase activity helicase activity protein binding ATP binding nucleus cytoplasm cytosol cytoplasmic stress granule negative regulation of transposition, RNA-mediated hydrolase activity viral replication complex gene silencing by RNA 5'-3' RNA helicase activity posttranscriptional gene silencing by RNA gene silencing by miRNA mRNA cleavage involved in gene silencing by miRNA cytoplasmic ribonucleoprotein granule P granule defense response to virus positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization uc008qun.1 uc008qun.2 uc008qun.3 uc008qun.4 uc008qun.5 uc008qun.6 
ENSMUST00000168033.3 Vmn2r114 ENSMUST00000168033.3 vomeronasal 2, receptor 114 (from RefSeq NM_001102584.1) E9Q281 E9Q281_MOUSE ENSMUST00000168033.1 ENSMUST00000168033.2 NM_001102584 Vmn2r114 uc009vbr.1 uc009vbr.2 uc009vbr.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vbr.1 uc009vbr.2 uc009vbr.3 
ENSMUST00000168039.8 Pdgfd ENSMUST00000168039.8 platelet-derived growth factor, D polypeptide, transcript variant 1 (from RefSeq NM_027924.3) ENSMUST00000168039.1 ENSMUST00000168039.2 ENSMUST00000168039.3 ENSMUST00000168039.4 ENSMUST00000168039.5 ENSMUST00000168039.6 ENSMUST00000168039.7 NM_027924 PDGFD_MOUSE Q3URF6 Q8K2L3 Q925I7 Q9D1L8 Scdgfb uc009oby.1 uc009oby.2 Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB (By similarity). Secreted Note=Released by platelets upon wounding. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=Q925I7-1; Sequence=Displayed; Name=2; IsoId=Q925I7-2; Sequence=VSP_020616; Name=3; Synonyms=Short; IsoId=Q925I7-3; Sequence=VSP_020617, VSP_020618; Expressed at high levels in developing heart, lung, kidney and some muscle derivatives. Moderately expressed in liver, brain and testis. In the kidney, localized to glomerular mesangial cells and vascular smooth muscle cells. Up-regulated in areas of renal fibrosis. In mice with unilateral ureteral obstruction, expressed in interstitial cells at day 4, with an increased to maximal expression at day 14. Activated by proteolytic cleavage. Proteolytic removal of the N- terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form (By similarity). Belongs to the PDGF/VEGF growth factor family. platelet-derived growth factor receptor binding extracellular region extracellular space multicellular organism development growth factor activity positive regulation of cell proliferation cellular process positive regulation of phosphatidylinositol 3-kinase signaling membrane positive regulation of cell migration positive regulation of protein autophosphorylation cellular response to platelet-derived growth factor stimulus positive regulation of MAP kinase activity platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation positive regulation of smooth muscle cell proliferation regulation of peptidyl-tyrosine phosphorylation positive regulation of cell division cellular response to hydrogen peroxide positive regulation of ERK1 and ERK2 cascade cellular response to amino acid stimulus cellular response to transforming growth factor beta stimulus positive regulation of smooth muscle cell chemotaxis positive regulation of glomerular mesangial cell proliferation positive regulation of monocyte extravasation uc009oby.1 uc009oby.2 
ENSMUST00000168048.2 Gm17171 ENSMUST00000168048.2 Gm17171 (from geneSymbol) ENSMUST00000168048.1 uc289tky.1 uc289tky.2 uc289tky.1 uc289tky.2 
ENSMUST00000168050.3 Vmn2r104 ENSMUST00000168050.3 vomeronasal 2, receptor 104 (from RefSeq NM_001104566.1) E9Q2J5 E9Q2J5_MOUSE ENSMUST00000168050.1 ENSMUST00000168050.2 NM_001104566 Vmn2r104 uc009vbi.1 uc009vbi.2 uc009vbi.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vbi.1 uc009vbi.2 uc009vbi.3 
ENSMUST00000168064.3 Vgll3 ENSMUST00000168064.3 vestigial like family member 3, transcript variant 2 (from RefSeq NM_028572.2) E9Q1Y1 E9Q1Y1_MOUSE ENSMUST00000168064.1 ENSMUST00000168064.2 NM_028572 Vgll3 uc007zqk.1 uc007zqk.2 uc007zqk.3 uc007zqk.4 May act as a specific coactivator for the mammalian TEFs. Nucleus Belongs to the vestigial family. nucleus regulation of transcription, DNA-templated uc007zqk.1 uc007zqk.2 uc007zqk.3 uc007zqk.4 
ENSMUST00000168073.9 Tdrd6 ENSMUST00000168073.9 tudor domain containing 6, transcript variant 2 (from RefSeq NM_198418.2) E9PZ50 E9PZ50_MOUSE ENSMUST00000168073.1 ENSMUST00000168073.2 ENSMUST00000168073.3 ENSMUST00000168073.4 ENSMUST00000168073.5 ENSMUST00000168073.6 ENSMUST00000168073.7 ENSMUST00000168073.8 NM_198418 Tdrd6 uc008cpi.1 uc008cpi.2 uc008cpi.3 uc008cpi.1 uc008cpi.2 uc008cpi.3 
ENSMUST00000168090.3 Igkv1-99 ENSMUST00000168090.3 Igkv1-99 (from geneSymbol) BC021781 ENSMUST00000168090.1 ENSMUST00000168090.2 F6XWB2 F6XWB2_MOUSE Igkv1-115 Igkv1-99 uc291fil.1 uc291fil.2 immunoglobulin production extracellular space immune response uc291fil.1 uc291fil.2 
ENSMUST00000168093.9 Prkd2 ENSMUST00000168093.9 protein kinase D2, transcript variant 2 (from RefSeq NM_001252458.1) ENSMUST00000168093.1 ENSMUST00000168093.2 ENSMUST00000168093.3 ENSMUST00000168093.4 ENSMUST00000168093.5 ENSMUST00000168093.6 ENSMUST00000168093.7 ENSMUST00000168093.8 KPCD2_MOUSE NM_001252458 Q3TCE5 Q3TDF0 Q3U4V4 Q8BZ03 uc009fig.1 uc009fig.2 uc009fig.3 uc009fig.4 Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:17226786, PubMed:20819079). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (PubMed:17226786). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-718 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (By similarity). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (By similarity). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation. During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (PubMed:20819079). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (By similarity). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (By similarity). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (By similarity). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (By similarity). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (By similarity). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by DAG and phorbol esters. Phorbol- ester/DAG-type domains bind DAG, mediating translocation to membranes. Autophosphorylation of Ser-711 and phosphorylation of Ser-707 by PKC relieves auto-inhibition by the PH domain. Catalytic activity is further increased by phosphorylation at Tyr-718 in response to oxidative stress. Interacts (via C-terminus) with LCK. Interacts (via N-terminus and zing-finger domain 1 and 2) with PRKCD in response to oxidative stress; the interaction is independent of PRKD2 tyrosine phosphorylation. Cytoplasm Cell membrane Golgi apparatus, trans-Golgi network Note=Translocation to the cell membrane is required for kinase activation. Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. Phosphorylation of Ser-873 correlates with the activation status of the kinase. Ser-707 is probably phosphorylated by PKC. Phosphorylation at Ser-244 by CSNK1D and CSNK1E promotes nuclear localization and substrate targeting. Phosphorylation at Ser-244, Ser- 707 and Ser-711 is required for nuclear localization. Phosphorylated at Tyr-438 by ABL1 in response to oxidative stress. Phosphorylated at Tyr- 718 by ABL1 specifically in response to oxidative stress; requires prior phosphorylation at Ser-707 or/and Ser-711. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. nucleotide binding angiogenesis positive regulation of endothelial cell proliferation adaptive immune response immune system process protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein kinase C binding ATP binding nucleus nucleoplasm cytoplasm Golgi apparatus cytosol plasma membrane protein phosphorylation cell adhesion cell death positive regulation of endothelial cell migration membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of interleukin-2 production positive regulation of interleukin-8 production positive regulation of CREB transcription factor activity positive regulation of peptidyl-serine phosphorylation intracellular signal transduction cellular response to vascular endothelial growth factor stimulus positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway positive regulation of blood vessel endothelial cell migration positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation metal ion binding vascular endothelial growth factor receptor signaling pathway T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade protein kinase D signaling positive regulation of histone deacetylase activity positive regulation of intracellular signal transduction positive regulation of DNA biosynthetic process positive regulation of endothelial cell chemotaxis uc009fig.1 uc009fig.2 uc009fig.3 uc009fig.4 
ENSMUST00000168098.8 Nr6a1 ENSMUST00000168098.8 nuclear receptor subfamily 6, group A, member 1, transcript variant 3 (from RefSeq NM_001159549.1) A2AQL8 A2AQM1 ENSMUST00000168098.1 ENSMUST00000168098.2 ENSMUST00000168098.3 ENSMUST00000168098.4 ENSMUST00000168098.5 ENSMUST00000168098.6 ENSMUST00000168098.7 Gcnf NM_001159549 NR6A1_MOUSE Q64249 Q687Z3 uc012but.1 uc012but.2 Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis. Homodimer. Interacts with UIMC1. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q64249-1; Sequence=Displayed; Name=2; IsoId=Q64249-2; Sequence=VSP_025929, VSP_025931; Name=3; IsoId=Q64249-3; Sequence=VSP_025928, VSP_025930; Expressed in the germ cells of both the adult testis and ovary, being most abundant in spermatids. Belongs to the nuclear hormone receptor family. NR6 subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated multicellular organism development gamete generation spermatogenesis zinc ion binding cell differentiation intracellular receptor signaling pathway protein homodimerization activity steroid hormone mediated signaling pathway sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc012but.1 uc012but.2 
ENSMUST00000168100.3 Cep295nl ENSMUST00000168100.3 Cell projection, cilium Note=Colocalizes to the motile cilium of mature spermatozoa. (from UniProt Q497N6) BC100451 C295L_MOUSE Cep295nl Ddc8 ENSMUST00000168100.1 ENSMUST00000168100.2 Kiaa1731nl P97320 Q497N6 uc033gbt.1 uc033gbt.2 uc033gbt.3 Cell projection, cilium Note=Colocalizes to the motile cilium of mature spermatozoa. Expressed in mature spermatozoa (at protein level). Detected in retina, lung and kidney. In brain, highly expressed in brain-stem, cerebral cortex and thalamus with lesser expression in cerebellum and hippocampus. Expressed during the postmeiotic stages of spermatogenesis. Detected at least at 14 dpc, the expression being enriched in kidney and small intestine. Within the nervous system, expression is prominent in the most superficial layers of the posterior cerebral cortex at 14 dpc and retina at 18 dpc. Expression is enriched in the posterior cerebral cortex at birth and declines at 7 days after birth. Expression is moderately up-regulated 2 days after intracranial injury and increases at 4 and 7 days post-injury. protein binding centrosome centriole cytosol cilium microtubule binding motile cilium cell projection regulation of centriole replication uc033gbt.1 uc033gbt.2 uc033gbt.3 
ENSMUST00000168115.8 Prpsap2 ENSMUST00000168115.8 phosphoribosyl pyrophosphate synthetase-associated protein 2, transcript variant 7 (from RefSeq NM_001364088.1) ENSMUST00000168115.1 ENSMUST00000168115.2 ENSMUST00000168115.3 ENSMUST00000168115.4 ENSMUST00000168115.5 ENSMUST00000168115.6 ENSMUST00000168115.7 KPRB_MOUSE NM_001364088 Q8R574 uc007jif.1 uc007jif.2 uc007jif.3 Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. Binds to PRPS1 and PRPS2. Belongs to the ribose-phosphate pyrophosphokinase family. magnesium ion binding ribose phosphate diphosphokinase complex ribose phosphate diphosphokinase activity cytoplasm 5-phosphoribose 1-diphosphate biosynthetic process purine nucleotide biosynthetic process nucleoside metabolic process nucleotide biosynthetic process macromolecular complex bone development uc007jif.1 uc007jif.2 uc007jif.3 
ENSMUST00000168120.3 Acot1 ENSMUST00000168120.3 acyl-CoA thioesterase 1 (from RefSeq NM_012006.2) ACOT1_MOUSE Cte1 ENSMUST00000168120.1 ENSMUST00000168120.2 NM_012006 O55137 Q549A9 uc007oeb.1 uc007oeb.2 uc007oeb.3 uc007oeb.4 Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20). Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence=; Reaction=decanoyl-CoA + H2O = CoA + decanoate + H(+); Xref=Rhea:RHEA:40059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40060; Evidence=; Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence=; Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=; Reaction=H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate; Xref=Rhea:RHEA:30139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30140; Evidence=; Reaction=eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+); Xref=Rhea:RHEA:40147, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32360, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40148; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40140; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+); Xref=Rhea:RHEA:40131, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40132; Evidence=; Reaction=(9E)-octadecenoyl-CoA + H2O = (9E)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40723, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30825, ChEBI:CHEBI:57287, ChEBI:CHEBI:77537; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40724; Evidence=; Kinetic parameters: KM=2.6 uM for C16:0-acyl-CoA ; KM=15.2 uM for C10:0-acyl-CoA ; KM=2.6 uM for C12:0-acyl-CoA ; KM=3.5 uM for C14:0-acyl-CoA ; KM=0.5 uM for C20:0-acyl-CoA ; KM=1.5 uM for C14:1-acyl-CoA ; KM=1.1 uM for C16:1-acyl-CoA ; KM=2.4 uM for C18:1(cis)-acyl-CoA ; KM=1.8 uM for C18:1(trans)-acyl-CoA ; KM=4.5 uM for C18:2-acyl-CoA ; KM=3.0 uM for C20:4-acyl-CoA ; Vmax=1.2 umol/min/mg enzyme with C16:0-acyl-CoA as substrate ; Vmax=0.192 umol/min/mg enzyme with C10:0-acyl-CoA as substrate ; Vmax=0.780 umol/min/mg enzyme with C12:0-acyl-CoA as substrate ; Vmax=1.68 umol/min/mg enzyme with C14:0-acyl-CoA as substrate ; Vmax=0.692 umol/min/mg enzyme with C18:0-acyl-CoA as substrate ; Vmax=0.245 umol/min/mg enzyme with C20:0-acyl-CoA as substrate ; Vmax=0.745 umol/min/mg enzyme with C14:1-acyl-CoA as substrate ; Vmax=0.621 umol/min/mg enzyme with C16:1-acyl-CoA as substrate ; Vmax=0.176 umol/min/mg enzyme with C18:1(cis)-acyl-CoA as substrate ; Vmax=0.188 umol/min/mg enzyme with C18:1(trans)-acyl-CoA as substrate ; Vmax=0.316 umol/min/mg enzyme with C18:2-acyl-CoA as substrate ; Vmax=0.007 umol/min/mg enzyme with C20:4-acyl-CoA as substrate ; Lipid metabolism; fatty acid metabolism. Monomer. Cytoplasm, cytosol Expressed in heart, kidney, brown adipose tissue, white adipose tissue, adrenal gland and muscle. In the liver, by peroxisome proliferator (Clofibrate) treatment, via the peroxisome proliferator-activated receptors (PPARs) or fasting for 24 hours. Belongs to the C/M/P thioester hydrolase family. long-chain fatty acid metabolic process cytoplasm mitochondrion cytosol lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process negative regulation of cardiac muscle cell apoptotic process palmitoyl-CoA hydrolase activity hydrolase activity thiolester hydrolase activity acyl-CoA hydrolase activity carboxylic ester hydrolase activity uc007oeb.1 uc007oeb.2 uc007oeb.3 uc007oeb.4 
ENSMUST00000168123.2 Gm17206 ENSMUST00000168123.2 Gm17206 (from geneSymbol) ENSMUST00000168123.1 uc289afw.1 uc289afw.2 uc289afw.1 uc289afw.2 
ENSMUST00000168129.10 Trappc12 ENSMUST00000168129.10 trafficking protein particle complex 12, transcript variant 7 (from RefSeq NR_165042.1) E9QLQ6 ENSMUST00000168129.1 ENSMUST00000168129.2 ENSMUST00000168129.3 ENSMUST00000168129.4 ENSMUST00000168129.5 ENSMUST00000168129.6 ENSMUST00000168129.7 ENSMUST00000168129.8 ENSMUST00000168129.9 NR_165042 Q8BX27 Q8K2L8 TPC12_MOUSE Trappc12 Ttc15 uc007nfx.1 uc007nfx.2 uc007nfx.3 uc007nfx.4 Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with CENPE. Endoplasmic reticulum-Golgi intermediate compartment Nucleus Note=Mainly localizes to structures resembling the Golgi and a small amount is found in the nucleus. Phosphorylated as the cells enter mitosis but is dephosphorylated at or before the onset of anaphase. The phosphorylated form recruits CENPE to kinetochores more efficiently than the non-phosphorylated form. Sequence=BAC33585.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; kinetochore endopeptidase activity nucleus endoplasmic reticulum-Golgi intermediate compartment proteolysis ER to Golgi vesicle-mediated transport Golgi organization vesicle-mediated transport TRAPP complex perinuclear region of cytoplasm protein oligomerization metaphase plate congression regulation of kinetochore assembly positive regulation of protein localization to kinetochore uc007nfx.1 uc007nfx.2 uc007nfx.3 uc007nfx.4 
ENSMUST00000168134.10 Ppfia1 ENSMUST00000168134.10 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1, transcript variant B (from RefSeq NM_001033319.2) B2RXW8 B2RXW8_MOUSE ENSMUST00000168134.1 ENSMUST00000168134.2 ENSMUST00000168134.3 ENSMUST00000168134.4 ENSMUST00000168134.5 ENSMUST00000168134.6 ENSMUST00000168134.7 ENSMUST00000168134.8 ENSMUST00000168134.9 NM_001033319 Ppfia1 uc012fya.1 uc012fya.2 uc012fya.3 Belongs to the liprin family. Liprin-alpha subfamily. protein binding cytosol focal adhesion axon dendrite macromolecular complex negative regulation of stress fiber assembly negative regulation of protein localization to plasma membrane uc012fya.1 uc012fya.2 uc012fya.3 
ENSMUST00000168137.2 5830462I19Rik ENSMUST00000168137.2 5830462I19Rik (from geneSymbol) AK134160 ENSMUST00000168137.1 uc292lqi.1 uc292lqi.2 uc292lqi.1 uc292lqi.2 
ENSMUST00000168148.2 Pfpl ENSMUST00000168148.2 pore forming protein-like (from RefSeq NM_019540.3) ENSMUST00000168148.1 NM_019540 Pfpl Q5RKV8 Q5RKV8_MOUSE uc008gua.1 uc008gua.2 molecular_function cellular_component membrane integral component of membrane defense response to bacterium uc008gua.1 uc008gua.2 
ENSMUST00000168156.3 Aadacl2fm2 ENSMUST00000168156.3 AADACL2 family member 2 (from RefSeq NM_001101531.1) Aadacl2fm2 ENSMUST00000168156.1 ENSMUST00000168156.2 Gm5538 NM_001101531 W4VSP6 W4VSP6_MOUSE uc012cpz.1 uc012cpz.2 uc012cpz.3 Membrane ; Single- pass type II membrane protein Belongs to the 'GDXG' lipolytic enzyme family. cellular_component catabolic process membrane integral component of membrane hydrolase activity short-chain carboxylesterase activity carboxylic ester hydrolase activity uc012cpz.1 uc012cpz.2 uc012cpz.3 
ENSMUST00000168158.3 Zscan4b ENSMUST00000168158.3 zinc finger and SCAN domain containing 4B (from RefSeq NM_001185173.1) E9Q3G0 E9Q3G0_MOUSE ENSMUST00000168158.1 ENSMUST00000168158.2 NM_001185173 Zscan4b uc012eyu.1 uc012eyu.2 Chromosome, telomere Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated embryo implantation metal ion binding uc012eyu.1 uc012eyu.2 
ENSMUST00000168161.3 Gm8229 ENSMUST00000168161.3 predicted gene 8229 (from RefSeq NM_001378719.1) ENSMUST00000168161.1 ENSMUST00000168161.2 Gm8229 K7N749 K7N749_MOUSE NM_001378719 uc288sva.1 uc288sva.2 uc288sva.3 molecular_function cellular_component biological_process uc288sva.1 uc288sva.2 uc288sva.3 
ENSMUST00000168165.2 Gm8104 ENSMUST00000168165.2 Gm8104 (from geneSymbol) ENSMUST00000168165.1 Gm8104 K7N744 K7N744_MOUSE uc288sqy.1 uc288sqy.2 uc288sqy.1 uc288sqy.2 
ENSMUST00000168166.8 Arpp19 ENSMUST00000168166.8 cAMP-regulated phosphoprotein 19, transcript variant 7 (from RefSeq NR_152135.1) ARP19_MOUSE ENSMUST00000168166.1 ENSMUST00000168166.2 ENSMUST00000168166.3 ENSMUST00000168166.4 ENSMUST00000168166.5 ENSMUST00000168166.6 ENSMUST00000168166.7 NR_152135 P56212 Q543L2 uc292iug.1 uc292iug.2 Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF- regulatory region of its mRNA (By similarity). Interacts (when phosphorylated at Ser-62) with PPP2R2D. Interacts with SNCA (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=ARPP-19; IsoId=P56212-1; Sequence=Displayed; Name=ARPP-16; IsoId=P56212-2; Sequence=VSP_018556; Isoform ARPP-19 is highly expressed in the embryo and its levels decrease progressively as development proceeds. In contrast, isoform ARPP-16 appears in the brain at the end of the first postnatal week and increases to reach a plateau. Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA. Belongs to the endosulfine family. G2/M transition of mitotic cell cycle mitotic cell cycle protein phosphatase inhibitor activity receptor binding cytoplasm cell cycle potassium channel regulator activity phosphatase inhibitor activity protein phosphatase regulator activity negative regulation of phosphoprotein phosphatase activity negative regulation of protein dephosphorylation negative regulation of catalytic activity regulation of phosphoprotein phosphatase activity positive regulation of gluconeogenesis positive regulation of Ras protein signal transduction cell division protein phosphatase 2A binding uc292iug.1 uc292iug.2 
ENSMUST00000168171.8 Cyp4f15 ENSMUST00000168171.8 cytochrome P450, family 4, subfamily f, polypeptide 15, transcript variant 1 (from RefSeq NM_134127.1) Cyp4f15 ENSMUST00000168171.1 ENSMUST00000168171.2 ENSMUST00000168171.3 ENSMUST00000168171.4 ENSMUST00000168171.5 ENSMUST00000168171.6 ENSMUST00000168171.7 NM_134127 Q99N18 Q99N18_MOUSE uc008bxk.1 uc008bxk.2 uc008bxk.3 Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc008bxk.1 uc008bxk.2 uc008bxk.3 
ENSMUST00000168175.3 Vmn2r115 ENSMUST00000168175.3 vomeronasal 2, receptor 115 (from RefSeq NM_001104579.1) E9PW45 E9PYG3 E9Q0E7 E9Q0E7_MOUSE E9Q7B2 ENSMUST00000168175.1 ENSMUST00000168175.2 NM_001104579 Vmn2r112 Vmn2r115 uc009vbs.1 uc009vbs.2 uc009vbs.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vbs.1 uc009vbs.2 uc009vbs.3 
ENSMUST00000168185.8 Tonsl ENSMUST00000168185.8 tonsoku-like, DNA repair protein (from RefSeq NM_183091.3) ENSMUST00000168185.1 ENSMUST00000168185.2 ENSMUST00000168185.3 ENSMUST00000168185.4 ENSMUST00000168185.5 ENSMUST00000168185.6 ENSMUST00000168185.7 G3UW83 G3UW83_MOUSE NM_183091 Tonsl uc007wle.1 uc007wle.2 uc007wle.3 uc007wle.4 Chromosome Belongs to the Tonsoku family. double-strand break repair via homologous recombination nucleoplasm DNA replication factor A complex nuclear body replication fork processing FACT complex histone binding MCM complex nuclear replication fork uc007wle.1 uc007wle.2 uc007wle.3 uc007wle.4 
ENSMUST00000168187.2 Gm17036 ENSMUST00000168187.2 Gm17036 (from geneSymbol) ENSMUST00000168187.1 uc289ntb.1 uc289ntb.2 uc289ntb.1 uc289ntb.2 
ENSMUST00000168189.8 Xpo6 ENSMUST00000168189.8 exportin 6, transcript variant 1 (from RefSeq NM_001311143.2) ENSMUST00000168189.1 ENSMUST00000168189.2 ENSMUST00000168189.3 ENSMUST00000168189.4 ENSMUST00000168189.5 ENSMUST00000168189.6 ENSMUST00000168189.7 NM_001311143 Q3U3K7 Q6PEF3 Q924Z6 Q9D0K9 Ranbp20 XPO6_MOUSE uc009jqs.1 uc009jqs.2 uc009jqs.3 uc009jqs.4 Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner. Nucleus Cytoplasm Note=Shuttles between the nucleus and the cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q924Z6-1; Sequence=Displayed; Name=2; IsoId=Q924Z6-2; Sequence=VSP_018467; Name=3; IsoId=Q924Z6-3; Sequence=VSP_018466, VSP_018468; Belongs to the exportin family. nuclear export signal receptor activity nucleus nucleolus cytoplasm cytosol plasma membrane protein export from nucleus intracellular protein transport Ran GTPase binding protein transport macromolecular complex uc009jqs.1 uc009jqs.2 uc009jqs.3 uc009jqs.4 
ENSMUST00000168194.3 Zfp511 ENSMUST00000168194.3 zinc finger protein 511, transcript variant 4 (from RefSeq NR_176428.1) ENSMUST00000168194.1 ENSMUST00000168194.2 NR_176428 Q6P0X2 ZN511_MOUSE Znf511 uc012fwe.1 uc012fwe.2 uc012fwe.3 May be involved in transcriptional regulation. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P0X2-1; Sequence=Displayed; Name=2; IsoId=Q6P0X2-2; Sequence=VSP_035623; Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus biological_process metal ion binding uc012fwe.1 uc012fwe.2 uc012fwe.3 
ENSMUST00000168230.3 Vmn2r70 ENSMUST00000168230.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N702) ENSMUST00000168230.1 ENSMUST00000168230.2 K7N702 K7N702_MOUSE Vmn2r70 uc012fok.1 uc012fok.2 uc012fok.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012fok.1 uc012fok.2 uc012fok.3 
ENSMUST00000168264.2 Armcx2 ENSMUST00000168264.2 armadillo repeat containing, X-linked 2, transcript variant 1 (from RefSeq NM_026139.4) A2AKS5 ARMX2_MOUSE ENSMUST00000168264.1 Kiaa0512 NM_026139 Q6A058 Q9CXI9 uc009ugq.1 uc009ugq.2 uc009ugq.3 uc009ugq.4 May regulate the dynamics and distribution of mitochondria in neural cells. Mitochondrion Mitochondrion outer membrane ; Single- pass membrane protein Widely expressed in the adult nervous tissue, especially in the forebrain, including the cerebral cortex, hippocampus and thalamus. Belongs to the eutherian X-chromosome-specific Armcx family. Sequence=BAD32238.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component mitochondrion mitochondrial outer membrane biological_process membrane integral component of membrane uc009ugq.1 uc009ugq.2 uc009ugq.3 uc009ugq.4 
ENSMUST00000168272.9 Dcpp2 ENSMUST00000168272.9 Dcpp2 (from geneSymbol) BC171996 Dcpp2 E9PYC2 E9PYC2_MOUSE ENSMUST00000168272.1 ENSMUST00000168272.2 ENSMUST00000168272.3 ENSMUST00000168272.4 ENSMUST00000168272.5 ENSMUST00000168272.6 ENSMUST00000168272.7 ENSMUST00000168272.8 uc029tba.1 uc029tba.2 uc029tba.3 molecular_function extracellular space biological_process uc029tba.1 uc029tba.2 uc029tba.3 
ENSMUST00000168275.9 Tdrd3 ENSMUST00000168275.9 tudor domain containing 3, transcript variant 1 (from RefSeq NM_172605.3) E9Q2Q4 ENSMUST00000168275.1 ENSMUST00000168275.2 ENSMUST00000168275.3 ENSMUST00000168275.4 ENSMUST00000168275.5 ENSMUST00000168275.6 ENSMUST00000168275.7 ENSMUST00000168275.8 NM_172605 Q6NZG7 Q8BZW6 Q8C1A4 Q91W18 TDRD3_MOUSE uc007uug.1 uc007uug.2 uc007uug.3 uc007uug.4 Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1. Component of mRNA stress granules. Interacts with FMR1, FXR1, FXR2, EWSR1, FUS, SERBP1, EEF1A1 and DDX3X or DDX3Y, and with the small nuclear ribonucleoprotein-associated proteins SNRPB and SNRPN. Interacts with 'Lys-48'-linked tetra-ubiquitin, but not with monoubiquitin or 'Lys-63'-linked ubiquitin chains. May interact with the exon junction complex (EJC) composed at least of CASC3, EIF4A3, MAGOH and RBM8A. Interacts with POLR2A (via the C-terminal domain (CTD)). Cytoplasm Nucleus Note=Predominantly cytoplasmic. Associated with actively translating polyribosomes. Component of stress granules. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q91W18-1; Sequence=Displayed; Name=2; IsoId=Q91W18-2; Sequence=VSP_034485; Name=3; IsoId=Q91W18-3; Sequence=VSP_037054; The Tudor domain specifically recognizes and binds asymmetric dimethylation of histone H3 'Arg-17' (H3R17me2a) and histones H4 'Arg- 3', 2 tags for epigenetic transcriptional activation. Sequence=AAH05670.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH66144.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC26033.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC28263.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; chromatin binding transcription coactivator activity RNA binding nucleus nucleoplasm cytoplasm Golgi apparatus cytosol chromatin organization mRNA processing methylated histone binding exon-exon junction complex positive regulation of nucleic acid-templated transcription uc007uug.1 uc007uug.2 uc007uug.3 uc007uug.4 
ENSMUST00000168276.8 Atp8b2 ENSMUST00000168276.8 ATPase, class I, type 8B, member 2, transcript variant 2 (from RefSeq NM_001081182.3) Atp8b2 E9QAL4 E9QAL4_MOUSE ENSMUST00000168276.1 ENSMUST00000168276.2 ENSMUST00000168276.3 ENSMUST00000168276.4 ENSMUST00000168276.5 ENSMUST00000168276.6 ENSMUST00000168276.7 NM_001081182 uc033huy.1 uc033huy.2 uc033huy.3 Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Membrane ulti-pass membrane protein Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. nucleotide binding magnesium ion binding ATP binding Golgi apparatus plasma membrane phospholipid transport membrane integral component of membrane uc033huy.1 uc033huy.2 uc033huy.3 
ENSMUST00000168284.3 Gm17059 ENSMUST00000168284.3 predicted gene 17059 (from RefSeq NR_155871.1) ENSMUST00000168284.1 ENSMUST00000168284.2 NR_155871 uc287rkn.1 uc287rkn.2 uc287rkn.3 uc287rkn.1 uc287rkn.2 uc287rkn.3 
ENSMUST00000168298.2 Krtap10-22 ENSMUST00000168298.2 predicted gene 3238 (from RefSeq NM_001101630.1) ENSMUST00000168298.1 Gm3238 NM_001101630 W4VSP7 W4VSP7_MOUSE uc011xhk.1 uc011xhk.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc011xhk.1 uc011xhk.2 
ENSMUST00000168302.8 Stat4 ENSMUST00000168302.8 signal transducer and activator of transcription 4, transcript variant 2 (from RefSeq NM_001308266.1) ENSMUST00000168302.1 ENSMUST00000168302.2 ENSMUST00000168302.3 ENSMUST00000168302.4 ENSMUST00000168302.5 ENSMUST00000168302.6 ENSMUST00000168302.7 NM_001308266 Q3V157 Q3V157_MOUSE Stat4 uc011wkn.1 uc011wkn.2 uc011wkn.3 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Homozygous knockout mice for this gene exhibit reduced inflammation and cytokine production in response to immune challenge. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Cytoplasm cleus Belongs to the transcription factor STAT family. DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated signal transduction cytokine-mediated signaling pathway identical protein binding positive regulation of transcription from RNA polymerase II promoter uc011wkn.1 uc011wkn.2 uc011wkn.3 
ENSMUST00000168306.8 Gm3029 ENSMUST00000168306.8 Gm3029 (from geneSymbol) ENSMUST00000168306.1 ENSMUST00000168306.2 ENSMUST00000168306.3 ENSMUST00000168306.4 ENSMUST00000168306.5 ENSMUST00000168306.6 ENSMUST00000168306.7 Gm3029 Gm8159 K7N6Y0 K7N6Y0_MOUSE uc288qio.1 uc288qio.2 molecular_function cellular_component biological_process uc288qio.1 uc288qio.2 
ENSMUST00000168318.3 Or5v1 ENSMUST00000168318.3 olfactory receptor family 5 subfamily V member 1 (from RefSeq NM_146328.2) A2RT31 A2RT31_MOUSE ENSMUST00000168318.1 ENSMUST00000168318.2 NM_146328 Olfr110 Or5v1 uc008cnb.1 uc008cnb.2 uc008cnb.3 uc008cnb.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB173127.1, CB174133.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008cnb.1 uc008cnb.2 uc008cnb.3 uc008cnb.4 
ENSMUST00000168326.2 Vmn1r152 ENSMUST00000168326.2 vomeronasal 1 receptor 152 (from RefSeq NM_001166752.1) E9Q9N3 E9Q9N3_MOUSE ENSMUST00000168326.1 NM_001166752 Vmn1r152 uc012fec.1 uc012fec.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fec.1 uc012fec.2 
ENSMUST00000168338.2 Trmt61a ENSMUST00000168338.2 tRNA methyltransferase 61A, transcript variant 2 (from RefSeq NM_001099792.1) ENSMUST00000168338.1 NM_001099792 Q80XC2 Q8BMD4 Q8BX33 TRM61_MOUSE Trm61 uc007pdp.1 uc007pdp.2 Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)- methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries. Reaction=adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)- methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43152, Rhea:RHEA-COMP:10365, Rhea:RHEA-COMP:10366, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=2.1.1.220; Evidence=; Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)- methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:55392, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12415, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; Evidence=; Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A. Nucleus Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. nucleus tRNA processing methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity transferase activity tRNA methylation tRNA (m1A) methyltransferase complex methylation mRNA methylation uc007pdp.1 uc007pdp.2 
ENSMUST00000168340.2 Defa27 ENSMUST00000168340.2 defensin, alpha, 27 (from RefSeq NM_001170955.1) Defa25 Defa27 ENSMUST00000168340.1 K7N7D8 K7N7D8_MOUSE NM_001170955 uc291yqa.1 uc291yqa.2 Secreted Belongs to the alpha-defensin family. innate immune response in mucosa extracellular region extracellular space defense response antibacterial humoral response defense response to bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium membrane disruption in other organism cellular response to lipopolysaccharide uc291yqa.1 uc291yqa.2 
ENSMUST00000168345.6 Lamtor3 ENSMUST00000168345.6 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 (from RefSeq NM_019920.2) ENSMUST00000168345.1 ENSMUST00000168345.2 ENSMUST00000168345.3 ENSMUST00000168345.4 ENSMUST00000168345.5 Lamtor3 NM_019920 Q542I7 Q542I7_MOUSE uc008rms.1 uc008rms.2 uc008rms.3 Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the LAMTOR3 family. guanyl-nucleotide exchange factor activity regulation of TOR signaling positive regulation of TOR signaling cellular protein localization binding, bridging cellular response to amino acid stimulus Ragulator complex uc008rms.1 uc008rms.2 uc008rms.3 
ENSMUST00000168347.2 5330438I03Rik ENSMUST00000168347.2 5330438I03Rik (from geneSymbol) ENSMUST00000168347.1 LF192981 uc287nmv.1 uc287nmv.2 uc287nmv.1 uc287nmv.2 
ENSMUST00000168386.9 Prr36 ENSMUST00000168386.9 proline rich 36 (from RefSeq NM_207203.2) BC068157 E9PV26 E9PV26_MOUSE ENSMUST00000168386.1 ENSMUST00000168386.2 ENSMUST00000168386.3 ENSMUST00000168386.4 ENSMUST00000168386.5 ENSMUST00000168386.6 ENSMUST00000168386.7 ENSMUST00000168386.8 NM_207203 Prr36 uc012fzb.1 uc012fzb.2 molecular_function cellular_component biological_process uc012fzb.1 uc012fzb.2 
ENSMUST00000168392.2 Vmn1r260 ENSMUST00000168392.2 vomeronasal 1 receptor 260 (from RefSeq NM_001166756.1) ENSMUST00000168392.1 Gm5725 Gm8720 K9J7F4 K9J7F4_MOUSE NM_001166756 Vmn1r249 Vmn1r260 uc012fep.1 uc012fep.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fep.1 uc012fep.2 
ENSMUST00000168398.2 Vmn1r126 ENSMUST00000168398.2 vomeronasal 1 receptor 126 (from RefSeq NM_001166838.1) ENSMUST00000168398.1 L7N2C8 L7N2C8_MOUSE NM_001166838 Vmn1r126 uc012fda.1 uc012fda.2 uc012fda.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fda.1 uc012fda.2 uc012fda.3 
ENSMUST00000168410.9 Tbc1d24 ENSMUST00000168410.9 TBC1 domain family, member 24, transcript variant 4 (from RefSeq NM_173186.4) A5D6Q7 ENSMUST00000168410.1 ENSMUST00000168410.2 ENSMUST00000168410.3 ENSMUST00000168410.4 ENSMUST00000168410.5 ENSMUST00000168410.6 ENSMUST00000168410.7 ENSMUST00000168410.8 Kiaa1171 NM_173186 Q3TTZ8 Q3UH11 Q3UUG6 Q6ZPW4 Q8BH92 Q8BNF2 Q8C3C6 Q8C3W8 TBC24_MOUSE uc008auw.1 uc008auw.2 uc008auw.3 uc008auw.4 May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515). Involved in the regulation of synaptic vesicle trafficking (By similarity). Interacts with ARF6. Cell membrane ; Peripheral membrane protein Cytoplasm Cytoplasmic vesicle membrane Presynapse Note=Mainly cytoplasmatic with partial expression at the plasma membrane (By similarity). Associates with certain types of membrane phosphoinositides, preferentially those phosphorylated at the D5 position of the inositol ring such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UUG6-1; Sequence=Displayed; Name=2; IsoId=Q3UUG6-2; Sequence=VSP_025702; Expressed in brain, particularly at the level of the cortex and the hippocampus. Expressed in the inner ear in spiral ganglion cells, a collection of neurons critical for hearing and balance. The Rab-GAP TBC domain is essential for phosphatidylinositol binding. Sequence=BAC39035.1; Type=Frameshift; Evidence=; Sequence=BAC98114.1; Type=Erroneous initiation; Evidence=; molecular_function GTPase activator activity cytoplasm plasma membrane membrane cell junction cytoplasmic vesicle membrane neuron projection development cytoplasmic vesicle neuromuscular junction terminal bouton positive regulation of GTPase activity positive regulation of dendrite morphogenesis negative regulation of peptidyl-cysteine S-nitrosylation negative regulation of oxidative stress-induced neuron death positive regulation of excitatory postsynaptic potential positive regulation of neuron migration uc008auw.1 uc008auw.2 uc008auw.3 uc008auw.4 
ENSMUST00000168431.7 Map4k4 ENSMUST00000168431.7 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; (from UniProt F8VPL5) AK129191 ENSMUST00000168431.1 ENSMUST00000168431.2 ENSMUST00000168431.3 ENSMUST00000168431.4 ENSMUST00000168431.5 ENSMUST00000168431.6 F8VPL5 F8VPL5_MOUSE Map4k4 uc287hov.1 uc287hov.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. protein kinase activity ATP binding protein phosphorylation uc287hov.1 uc287hov.2 
ENSMUST00000168438.9 Pde4dip ENSMUST00000168438.9 phosphodiesterase 4D interacting protein (myomegalin), transcript variant 6 (from RefSeq NM_001289702.1) E9Q1A0 E9Q1A0_MOUSE ENSMUST00000168438.1 ENSMUST00000168438.2 ENSMUST00000168438.3 ENSMUST00000168438.4 ENSMUST00000168438.5 ENSMUST00000168438.6 ENSMUST00000168438.7 ENSMUST00000168438.8 NM_001289702 Pde4dip uc012cuh.1 uc012cuh.2 uc012cuh.3 uc012cuh.4 Golgi apparatus microtubule organizing center uc012cuh.1 uc012cuh.2 uc012cuh.3 uc012cuh.4 
ENSMUST00000168440.3 Vmn2r118 ENSMUST00000168440.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q1C1) E9Q1C1 E9Q1C1_MOUSE ENSMUST00000168440.1 ENSMUST00000168440.2 Vmn2r118 uc009vbv.1 uc009vbv.2 uc009vbv.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vbv.1 uc009vbv.2 uc009vbv.3 
ENSMUST00000168442.3 Gm3235 ENSMUST00000168442.3 Gm3235 (from geneSymbol) ENSMUST00000168442.1 ENSMUST00000168442.2 uc292cad.1 uc292cad.2 uc292cad.3 uc292cad.1 uc292cad.2 uc292cad.3 
ENSMUST00000168452.3 Gm5916 ENSMUST00000168452.3 predicted gene 5916 (from RefSeq NM_001167587.1) ENSMUST00000168452.1 ENSMUST00000168452.2 G5E8W5 G5E8W5_MOUSE Gm5916 NM_001167587 uc012gqr.1 uc012gqr.2 uc012gqr.3 molecular_function cellular_component biological_process uc012gqr.1 uc012gqr.2 uc012gqr.3 
ENSMUST00000168457.3 Utf1 ENSMUST00000168457.3 undifferentiated embryonic cell transcription factor 1 (from RefSeq NM_009482.2) ENSMUST00000168457.1 ENSMUST00000168457.2 NM_009482 O70530 Q6J1H4 UTF1_MOUSE Utf1 uc009kgf.1 uc009kgf.2 uc009kgf.3 Acts as a transcriptional coactivator of ATF2. Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP. Nucleus Event=Alternative initiation; Named isoforms=2; Name=1 ; IsoId=Q6J1H4-1; Sequence=Displayed; Name=2 ; IsoId=Q6J1H4-2; Sequence=VSP_052292; Expressed mainly in pluripotent cells with expression rapidly down-regulated upon cell differentiation. First detected in the embryo at the blastocyst stage. Little or no expression detected in adult tissues. The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters. Phosphorylated. Sequence=AAT38948.1; Type=Erroneous initiation; Evidence=; transcription coactivator activity protein binding nucleus positive regulation of transcription from RNA polymerase II promoter HMG box domain binding uc009kgf.1 uc009kgf.2 uc009kgf.3 
ENSMUST00000168461.8 Rnf19b ENSMUST00000168461.8 ring finger protein 19B, transcript variant 2 (from RefSeq NM_029219.2) E9Q2L7 E9Q2L7_MOUSE ENSMUST00000168461.1 ENSMUST00000168461.2 ENSMUST00000168461.3 ENSMUST00000168461.4 ENSMUST00000168461.5 ENSMUST00000168461.6 ENSMUST00000168461.7 NM_029219 Rnf19b uc008uvy.1 uc008uvy.2 uc008uvy.3 Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence=; ubiquitin-protein transferase activity endoplasmic reticulum cytosol membrane integral component of membrane protein ubiquitination transferase activity ubiquitin binding metal ion binding protein autoubiquitination ubiquitin protein ligase activity uc008uvy.1 uc008uvy.2 uc008uvy.3 
ENSMUST00000168470.2 Gm17233 ENSMUST00000168470.2 Gm17233 (from geneSymbol) ENSMUST00000168470.1 uc288vpu.1 uc288vpu.2 uc288vpu.1 uc288vpu.2 
ENSMUST00000168479.3 Nynrin ENSMUST00000168479.3 NYN domain and retroviral integrase containing (from RefSeq NM_001040072.1) B9EKP9 ENSMUST00000168479.1 ENSMUST00000168479.2 Kiaa1305 NM_001040072 NYNRI_MOUSE Q32KG8 Q3V1I3 Q5DTZ0 uc007uaz.1 uc007uaz.2 uc007uaz.3 uc007uaz.4 Membrane ; Multi-pass membrane protein The gene encoding this protein may have arisen from the fusion of a cellular gene with retroviral sequences prior to the marsupial-eutherian split. Sequence and structural analyses suggest that the integrase catalytic domain is inactive. Sequence=CAI99159.1; Type=Erroneous gene model prediction; Evidence=; molecular_function nucleic acid binding cellular_component biological_process DNA integration membrane integral component of membrane uc007uaz.1 uc007uaz.2 uc007uaz.3 uc007uaz.4 
ENSMUST00000168480.10 Gm21560 ENSMUST00000168480.10 Gm21560 (from geneSymbol) D3YX19 D3YX20 D3Z493 D3Z4A6 D3Z7A1 D3Z7A4 D3Z7A4_MOUSE E9PUA1 E9PUT7 E9PV20 E9PWK8 E9PWS3 E9PWV6 E9PX97 E9PXJ2 E9PXK9 E9PXT2 E9PY20 E9PY88 E9PZG8 E9Q0A9 E9Q0L3 E9Q110 E9Q1F3 E9Q1Q3 E9Q268 E9Q2B3 E9Q4G2 E9Q4U4 E9Q4X6 E9Q521 E9Q5Q4 E9Q751 E9Q7S2 E9Q7S7 E9Q940 E9QA01 E9QA13 E9QAY0 ENSMUST00000168480.1 ENSMUST00000168480.2 ENSMUST00000168480.3 ENSMUST00000168480.4 ENSMUST00000168480.5 ENSMUST00000168480.6 ENSMUST00000168480.7 ENSMUST00000168480.8 ENSMUST00000168480.9 F8VPS8 Gm10338 Gm21560 uc288qob.1 uc288qob.2 uc288qob.1 uc288qob.2 
ENSMUST00000168483.9 Zfp600 ENSMUST00000168483.9 zinc finger protein 600, transcript variant 1 (from RefSeq NM_001177546.2) A2A7V0 A2A7V0_MOUSE E9PW48 ENSMUST00000168483.1 ENSMUST00000168483.2 ENSMUST00000168483.3 ENSMUST00000168483.4 ENSMUST00000168483.5 ENSMUST00000168483.6 ENSMUST00000168483.7 ENSMUST00000168483.8 Gm13242 NM_001177546 Zfp600 uc012doz.1 uc012doz.2 uc012doz.3 uc012doz.4 nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc012doz.1 uc012doz.2 uc012doz.3 uc012doz.4 
ENSMUST00000168489.3 Vmn2r59 ENSMUST00000168489.3 vomeronasal 2, receptor 59 (from RefSeq NM_001105056.1) E9PUT5 E9PUT5_MOUSE E9PVG6 E9Q4U2 E9Q5S1 E9Q5Z2 ENSMUST00000168489.1 ENSMUST00000168489.2 NM_001105056 Vmn2r59 uc012fiu.1 uc012fiu.2 uc012fiu.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012fiu.1 uc012fiu.2 uc012fiu.3 
ENSMUST00000168499.9 Nlrx1 ENSMUST00000168499.9 NLR family member X1, transcript variant 3 (from RefSeq NM_001163742.1) ENSMUST00000168499.1 ENSMUST00000168499.2 ENSMUST00000168499.3 ENSMUST00000168499.4 ENSMUST00000168499.5 ENSMUST00000168499.6 ENSMUST00000168499.7 ENSMUST00000168499.8 NLRX1_MOUSE NM_001163742 Q3TL44 Q3UKJ1 Q80W30 Q8C249 uc009pck.1 uc009pck.2 uc009pck.3 uc009pck.4 Participates in antiviral signaling (PubMed:35651602). Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (By similarity). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (By similarity). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (By similarity). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF- kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (By similarity). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (PubMed:35651602). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (PubMed:35651602). Homohexamer (By similarity). Interacts with MAVS (By similarity). Interacts with TUFM (By similarity). Mitochondrion outer membrane Expressed in macrophages (at protein level). In macrophages, transiently down-regulated in response to TLR3 ligands and to L.guyanensis containing dsRNA LRV1 virus infection; however, protein levels are not affected. The LRRCT domain mediates homodimerization and LRRNT mediates trimerization of the dimers. Females infected with L.guyanensis containing dsRNA LRV1 virus, have an increase in footpad swelling and, in thickness and in immune cell infiltration in the dermis (PubMed:35651602). They develop larger lesions (PubMed:35651602). Ifnb and Il6, but not Tnfa, mRNA levels are also increased (PubMed:35651602). Parasite burden is similar to infected wild type female (PubMed:35651602). In contrast, males infected with L.guyanensis containing dsRNA LRV1 virus have similar lesions compared to infected wild type male (PubMed:35651602). However, Ifnb mRNA levels in the lesions and parasite burden are reduced (PubMed:35651602). Belongs to the NLRP family. nucleotide binding immune system process protein binding ATP binding mitochondrion mitochondrial outer membrane plasma membrane membrane viral process cell junction negative regulation of interferon-beta production negative regulation of interleukin-6 production intracellular signal transduction negative regulation of RIG-I signaling pathway negative regulation of I-kappaB kinase/NF-kappaB signaling innate immune response negative regulation of innate immune response negative regulation of inflammatory response cytoplasm uc009pck.1 uc009pck.2 uc009pck.3 uc009pck.4 
ENSMUST00000168501.8 Phf8 ENSMUST00000168501.8 PHD finger protein 8, transcript variant 2 (from RefSeq NM_001113354.1) A2ABU8 A2ABV0 A2ABV2 ENSMUST00000168501.1 ENSMUST00000168501.2 ENSMUST00000168501.3 ENSMUST00000168501.4 ENSMUST00000168501.5 ENSMUST00000168501.6 ENSMUST00000168501.7 Kiaa1111 NM_001113354 PHF8_MOUSE Q80TJ7 Q8BLX8 Q8BLY0 Q8BZ61 Q8CG26 uc012hqt.1 uc012hqt.2 Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys- 20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. Reaction=2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:42032, Rhea:RHEA-COMP:9785, Rhea:RHEA- COMP:9787, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61976; EC=1.14.11.27; Evidence=; Reaction=2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60188, Rhea:RHEA-COMP:15541, Rhea:RHEA- COMP:15546, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61976; EC=1.14.11.65; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Interacts with POLR1B, UBTF, SETD1A, HCFC1, E2F1 and ZNF711 (By similarity). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (By similarity). Nucleus Nucleus, nucleolus Note=Recruited to H3K4me3 sites on chromatin during interphase (By similarity). Dissociates from chromatin when cells enter mitosis (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80TJ7-1; Sequence=Displayed; Name=2; IsoId=Q80TJ7-2; Sequence=VSP_014966, VSP_014969, VSP_014970; Name=3; IsoId=Q80TJ7-3; Sequence=VSP_014967, VSP_014968; The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 promotes its access to H3K9me2 (By similarity). The linker region is a critical determinant of demethylase specificity. It enables the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3 (By similarity). Phosphorylation at Ser-33 and Ser-84 are required for dissociation from chromatin and accumulation of H4K20Me1 levels during prophase. Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. Sequence=CAM17163.1; Type=Erroneous gene model prediction; Evidence=; G1/S transition of mitotic cell cycle chromatin binding iron ion binding nucleus nucleolus chromatin organization cell cycle brain development zinc ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors nuclear membrane histone demethylase activity histone demethylase activity (H3-K9 specific) histone H3-K9 demethylation methylated histone binding histone H4-K20 demethylation histone demethylase activity (H4-K20 specific) positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase I promoter metal ion binding dioxygenase activity histone demethylase activity (H3-K36 specific) oxidation-reduction process negative regulation of chromatin silencing at rDNA histone H3-K36 demethylation histone H3-K27 demethylation histone demethylase activity (H3-K27 specific) uc012hqt.1 uc012hqt.2 
ENSMUST00000168503.8 Fbxo6 ENSMUST00000168503.8 F-box protein 6, transcript variant 5 (from RefSeq NM_001163707.1) A2A7H0 A2A7H2 B2KFL0 B2KFL2 ENSMUST00000168503.1 ENSMUST00000168503.2 ENSMUST00000168503.3 ENSMUST00000168503.4 ENSMUST00000168503.5 ENSMUST00000168503.6 ENSMUST00000168503.7 FBX6_MOUSE Fbs2 Fbxo6b NM_001163707 Q3TML5 Q3UCB0 Q9QZN4 uc012dpl.1 uc012dpl.2 Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Protein modification; protein ubiquitination. Interacts with CHEK1 and CUL1 (By similarity). Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with VCP. Cytoplasm Present in liver and kidney (at protein level). Widely expressed. Weakly expressed in embryos. Sequence=CAM14908.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAQ51914.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAQ52206.1; Type=Erroneous gene model prediction; Evidence=; protein binding cytoplasm DNA repair glycoprotein catabolic process cellular response to DNA damage stimulus response to unfolded protein protein ubiquitination SCF ubiquitin ligase complex carbohydrate binding ER-associated ubiquitin-dependent protein catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process endoplasmic reticulum quality control compartment glycoprotein ERAD pathway ubiquitin protein ligase activity uc012dpl.1 uc012dpl.2 
ENSMUST00000168515.8 Ppfia4 ENSMUST00000168515.8 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4, transcript variant 1 (from RefSeq NM_001144855.1) B8QI36 B8QI36_MOUSE ENSMUST00000168515.1 ENSMUST00000168515.2 ENSMUST00000168515.3 ENSMUST00000168515.4 ENSMUST00000168515.5 ENSMUST00000168515.6 ENSMUST00000168515.7 NM_001144855 Ppfia4 ppfia4 uc011wse.1 uc011wse.2 Belongs to the liprin family. Liprin-alpha subfamily. protein binding biological_process synapse presynaptic active zone uc011wse.1 uc011wse.2 
ENSMUST00000168520.3 Atp23 ENSMUST00000168520.3 ATP23 metallopeptidase and ATP synthase assembly factor homolog, transcript variant 4 (from RefSeq NM_001358970.1) Atp23 ENSMUST00000168520.1 ENSMUST00000168520.2 G3UW46 G3UW46_MOUSE NM_001358970 Xrcc6bp1 uc007hhg.1 uc007hhg.2 uc007hhg.3 uc007hhg.4 Belongs to the peptidase M76 family. metalloendopeptidase activity cytosol plasma membrane proteolysis peptidase activity metallopeptidase activity hydrolase activity cell junction intracellular membrane-bounded organelle metal ion binding uc007hhg.1 uc007hhg.2 uc007hhg.3 uc007hhg.4 
ENSMUST00000168527.8 Dennd1b ENSMUST00000168527.8 DENN domain containing 1B, transcript variant 1 (from RefSeq NM_001166501.1) B2RUR7 DEN1B_MOUSE Dennd1b E9Q246 ENSMUST00000168527.1 ENSMUST00000168527.2 ENSMUST00000168527.3 ENSMUST00000168527.4 ENSMUST00000168527.5 ENSMUST00000168527.6 ENSMUST00000168527.7 NM_001166501 Q3U1T9 Q8CG96 Q9D5B9 uc007cwb.1 uc007cwb.2 uc007cwb.3 uc007cwb.4 Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP- bound RAB35 into its active GTP-bound form. Plays a role in clathrin- mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells. Interacts with RAB35 (PubMed:26774822). Interacts with clathrin heavy chain/CLTC (By similarity). Interacts with components of the adapter protein complex 2 (AP-2) AP2A2 and AP2B1 (By similarity). Interacts with CD3E (PubMed:26774822). Cytoplasm, cytosol Cytoplasmic vesicle, clathrin-coated vesicle Event=Alternative splicing; Named isoforms=5; Name=5; IsoId=Q3U1T9-1; Sequence=Displayed; Name=2; IsoId=Q3U1T9-2; Sequence=VSP_058173; Name=3; IsoId=Q3U1T9-3; Sequence=VSP_058174, VSP_058175; Name=4; IsoId=Q3U1T9-4; Sequence=VSP_058172; Name=1; IsoId=Q3U1T9-5; Sequence=VSP_058174, VSP_058176; Expressed in a subset of dendritic cells (DCs). The FXDXF motif mediates interaction the AP-2 complex. The clathrin box motif mediates interaction with clathrin. Phosphorylated on serine and/or threonine, possibly regulating the guanine nucleotide exchange factor (GEF) activity. Mice are developmentally normal and fertile but accumulate more splenic and lymph node CD4(+) and CD8(+) effector/memory T-cells with age. TH2 cells display increased TCR- mediated responses, due to delayed surface TCR down-modulation and recycling, and increased production of cytokines. Mice have increased antigen-induced allergic responses. guanyl-nucleotide exchange factor activity cytoplasm cytosol endocytosis protein transport nuclear speck Rab guanyl-nucleotide exchange factor activity Rab GTPase binding clathrin-coated vesicle cytoplasmic vesicle endocytic recycling T-helper 2 cell cytokine production intracellular membrane-bounded organelle positive regulation of GTPase activity regulation of immune response T cell receptor signaling pathway phosphatidylinositol phosphate binding uc007cwb.1 uc007cwb.2 uc007cwb.3 uc007cwb.4 
ENSMUST00000168529.9 Cyb5r4 ENSMUST00000168529.9 predicted gene, 57850, transcript variant 5 (from RefSeq NR_174608.1) E9Q129 ENSMUST00000168529.1 ENSMUST00000168529.2 ENSMUST00000168529.3 ENSMUST00000168529.4 ENSMUST00000168529.5 ENSMUST00000168529.6 ENSMUST00000168529.7 ENSMUST00000168529.8 NB5R4_MOUSE NR_174608 Ncb5or Q3TDX8 Q3TJH3 Q3U012 Q6VXY4 Q6VXY5 Q8BJV8 Q8BTI5 Q8R3H8 Q99LY4 Q99P29 uc009qyc.1 uc009qyc.2 uc009qyc.3 uc009qyc.4 NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reaction=2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+); Xref=Rhea:RHEA:46680, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.2.2; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Endoplasmic reticulum. Note=Soluble protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TDX8-4; Sequence=Displayed; Name=2; Synonyms=cb5/cb5rDelta12; IsoId=Q3TDX8-5; Sequence=VSP_041453; Ubiquitously expressed. Isoform 2 is expressed in testis, brain, skeletal muscle and in the male germline. Mice display insulin-deficient diabetes. Embryos and fetus develop normally. At 4 weeks of age, mice show have normal blood glucose levels but impaired glucose tolerance. Isolated islets have markedly impaired glucose- or arginine-stimulated insulin secretion. By 7 weeks of age, they develop severe hyperglycemia with markedly decreased serum insulin levels and nearly normal insulin tolerance. As the animals age, there is a progressive loss of beta cells in pancreatic islets, but there is no loss of alpha, delta, or PP cells. 4 week-old mice have enhanced sensitivity to the diabetogenic agent streptozotocin. Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. Sequence=AAH25438.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC41118.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE34044.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE42908.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; NADPH-hemoprotein reductase activity cytochrome-b5 reductase activity, acting on NAD(P)H protein binding cytoplasm endoplasmic reticulum generation of precursor metabolites and energy NADP metabolic process superoxide metabolic process NAD(P)H oxidase activity oxidoreductase activity oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor heme binding insulin secretion heme metabolic process glucose homeostasis response to antibiotic metal ion binding cell development perinuclear region of cytoplasm flavin adenine dinucleotide binding oxidation-reduction process uc009qyc.1 uc009qyc.2 uc009qyc.3 uc009qyc.4 
ENSMUST00000168536.9 Nt5c2 ENSMUST00000168536.9 5'-nucleotidase, cytosolic II, transcript variant 27 (from RefSeq NR_165076.1) 5NTC_MOUSE ENSMUST00000168536.1 ENSMUST00000168536.2 ENSMUST00000168536.3 ENSMUST00000168536.4 ENSMUST00000168536.5 ENSMUST00000168536.6 ENSMUST00000168536.7 ENSMUST00000168536.8 NR_165076 Nt5c2 Q3V1L4 Q6P223 Q8BZ43 Q9D8G6 uc008huh.1 uc008huh.2 uc008huh.3 uc008huh.4 Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine. Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP. Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency. Through these activities regulates the purine nucleoside/nucleotide pools within the cell. Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377, ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12485; Evidence=; Reaction=a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate = a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside; Xref=Rhea:RHEA:19961, ChEBI:CHEBI:18254, ChEBI:CHEBI:18274, ChEBI:CHEBI:58043, ChEBI:CHEBI:65317; EC=2.7.1.77; Evidence=; Reaction=H2O + IMP = inosine + phosphate; Xref=Rhea:RHEA:27718, ChEBI:CHEBI:15377, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474, ChEBI:CHEBI:58053; EC=3.1.3.99; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27719; Evidence=; Reaction=GMP + H2O = guanosine + phosphate; Xref=Rhea:RHEA:27714, ChEBI:CHEBI:15377, ChEBI:CHEBI:16750, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27715; Evidence=; Reaction=dGMP + H2O = 2'-deoxyguanosine + phosphate; Xref=Rhea:RHEA:29379, ChEBI:CHEBI:15377, ChEBI:CHEBI:17172, ChEBI:CHEBI:43474, ChEBI:CHEBI:57673; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29380; Evidence=; Reaction=dIMP + H2O = 2'-deoxyinosine + phosphate; Xref=Rhea:RHEA:29383, ChEBI:CHEBI:15377, ChEBI:CHEBI:28997, ChEBI:CHEBI:43474, ChEBI:CHEBI:61194; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29384; Evidence=; Reaction=H2O + XMP = phosphate + xanthosine; Xref=Rhea:RHEA:28530, ChEBI:CHEBI:15377, ChEBI:CHEBI:18107, ChEBI:CHEBI:43474, ChEBI:CHEBI:57464; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28531; Evidence=; Reaction=GMP + inosine = guanosine + IMP; Xref=Rhea:RHEA:69584, ChEBI:CHEBI:16750, ChEBI:CHEBI:17596, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115; Evidence=; Reaction=dGMP + inosine = 2'-deoxyguanosine + IMP; Xref=Rhea:RHEA:69580, ChEBI:CHEBI:17172, ChEBI:CHEBI:17596, ChEBI:CHEBI:57673, ChEBI:CHEBI:58053; Evidence=; Reaction=dIMP + inosine = 2'-deoxyinosine + IMP; Xref=Rhea:RHEA:69572, ChEBI:CHEBI:17596, ChEBI:CHEBI:28997, ChEBI:CHEBI:58053, ChEBI:CHEBI:61194; Evidence=; Reaction=inosine + UMP = IMP + uridine; Xref=Rhea:RHEA:69588, ChEBI:CHEBI:16704, ChEBI:CHEBI:17596, ChEBI:CHEBI:57865, ChEBI:CHEBI:58053; Evidence=; Reaction=CMP + inosine = cytidine + IMP; Xref=Rhea:RHEA:69592, ChEBI:CHEBI:17562, ChEBI:CHEBI:17596, ChEBI:CHEBI:58053, ChEBI:CHEBI:60377; Evidence=; Reaction=AMP + inosine = adenosine + IMP; Xref=Rhea:RHEA:69596, ChEBI:CHEBI:16335, ChEBI:CHEBI:17596, ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Allosterically activated by various compounds including ATP, 2,3-BPG/2,3-Bisphosphoglyceric acid and Ap4A/P1,P4- bis(5'-adenosyl) tetraphosphate. Binding of an allosteric activator is a prerequisiste to magnesium and substrate binding. Inhibited by inorganic phosphate. Homotetramer. Cytoplasm, cytosol Belongs to the 5'(3')-deoxyribonucleotidase family. nucleotide binding catalytic activity cellular_component cytoplasm metabolic process 5'-nucleotidase activity nucleotide metabolic process dephosphorylation hydrolase activity IMP metabolic process adenosine metabolic process metal ion binding uc008huh.1 uc008huh.2 uc008huh.3 uc008huh.4 
ENSMUST00000168551.2 H2al2b ENSMUST00000168551.2 H2A histone family member L2B (from RefSeq NM_001113395.1) A9Z055 A9Z055_MOUSE ENSMUST00000168551.1 H2al2b H2al2c NM_001113395 uc012hrw.1 uc012hrw.2 The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc012hrw.1 uc012hrw.2 
ENSMUST00000168574.9 Pid1 ENSMUST00000168574.9 phosphotyrosine interaction domain containing 1 (from RefSeq NM_001003948.2) ENSMUST00000168574.1 ENSMUST00000168574.2 ENSMUST00000168574.3 ENSMUST00000168574.4 ENSMUST00000168574.5 ENSMUST00000168574.6 ENSMUST00000168574.7 ENSMUST00000168574.8 NM_001003948 PCLI1_MOUSE Pcli1 Q3UAR0 Q3UBG2 Q68EE9 Q7TPS1 uc007bst.1 uc007bst.2 uc007bst.3 uc007bst.4 Increases proliferation of preadipocytes without affecting adipocytic differentiation. Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and CUBN. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UBG2-1; Sequence=Displayed; Name=2; IsoId=Q3UBG2-2; Sequence=VSP_022913; Sequence=AAH54112.1; Type=Erroneous initiation; Evidence=; Sequence=AAH80290.1; Type=Erroneous initiation; Evidence=; Sequence=BAE30002.1; Type=Erroneous initiation; Evidence=; Sequence=BAE30254.1; Type=Erroneous initiation; Evidence=; negative regulation of protein phosphorylation protein binding cytoplasm positive regulation of gene expression regulation of cell proliferation cellular response to leptin stimulus positive regulation of transcription from RNA polymerase II promoter negative regulation of glucose import negative regulation of insulin receptor signaling pathway regulation of mitochondrial membrane potential positive regulation of fat cell proliferation mitochondrion morphogenesis cellular response to cytokine stimulus cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to fatty acid negative regulation of protein localization to plasma membrane regulation of reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process negative regulation of ATP biosynthetic process positive regulation of ATP biosynthetic process uc007bst.1 uc007bst.2 uc007bst.3 uc007bst.4 
ENSMUST00000168578.3 Tmem238 ENSMUST00000168578.3 transmembrane protein 238 (from RefSeq NM_029384.1) A9JSM3 ENSMUST00000168578.1 ENSMUST00000168578.2 NM_029384 TM238_MOUSE uc009eyr.1 uc009eyr.2 uc009eyr.3 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009eyr.1 uc009eyr.2 uc009eyr.3 
ENSMUST00000168579.8 Slc16a3 ENSMUST00000168579.8 solute carrier family 16 (monocarboxylic acid transporters), member 3 (from RefSeq NM_001038653.1) ENSMUST00000168579.1 ENSMUST00000168579.2 ENSMUST00000168579.3 ENSMUST00000168579.4 ENSMUST00000168579.5 ENSMUST00000168579.6 ENSMUST00000168579.7 NM_001038653 Q3UDP9 Q3UDP9_MOUSE Slc16a3 uc007mux.1 uc007mux.2 uc007mux.3 Basolateral cell membrane ; Multi-pass membrane protein Lateral cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein plasma membrane integral component of plasma membrane monocarboxylic acid transmembrane transporter activity lactate transmembrane transporter activity monocarboxylic acid transport membrane integral component of membrane nuclear membrane plasma membrane lactate transport transmembrane transport integral component of postsynaptic density membrane uc007mux.1 uc007mux.2 uc007mux.3 
ENSMUST00000168580.2 Vmn1r242 ENSMUST00000168580.2 vomeronasal 1 receptor 242 (from RefSeq NM_001167151.1) ENSMUST00000168580.1 Gm4498 Gm8453 K9J7G4 K9J7G4_MOUSE NM_001167151 Vmn1r242 Vmn1r252 uc012fbt.1 uc012fbt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fbt.1 uc012fbt.2 
ENSMUST00000168584.9 Glt8d1 ENSMUST00000168584.9 glycosyltransferase 8 domain containing 1, transcript variant 17 (from RefSeq NM_001403342.1) ENSMUST00000168584.1 ENSMUST00000168584.2 ENSMUST00000168584.3 ENSMUST00000168584.4 ENSMUST00000168584.5 ENSMUST00000168584.6 ENSMUST00000168584.7 ENSMUST00000168584.8 GL8D1_MOUSE NM_001403342 Q3TV18 Q6NSU3 Q9CWT8 uc007swf.1 uc007swf.2 uc007swf.3 uc007swf.4 Membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NSU3-1; Sequence=Displayed; Name=2; IsoId=Q6NSU3-2; Sequence=VSP_025707, VSP_025708; Belongs to the glycosyltransferase 8 family. Golgi apparatus membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups uc007swf.1 uc007swf.2 uc007swf.3 uc007swf.4 
ENSMUST00000168612.8 Dhrs7c ENSMUST00000168612.8 dehydrogenase/reductase 7C (from RefSeq NM_001013013.2) B1ATJ2 DRS7C_MOUSE Dhrs7c ENSMUST00000168612.1 ENSMUST00000168612.2 ENSMUST00000168612.3 ENSMUST00000168612.4 ENSMUST00000168612.5 ENSMUST00000168612.6 ENSMUST00000168612.7 NM_001013013 Q8CHS7 Sdr32c2 Srp-35 uc011xwp.1 uc011xwp.2 uc011xwp.3 NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal (PubMed:21995425). Plays a role in the regulation of cardiac and skeletal muscle metabolic functions (PubMed:21995425, PubMed:27806939, PubMed:29330505) (Probable). Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal (PubMed:21995425). Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes (PubMed:27806939). Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid (PubMed:29330505). Reaction=all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH; Xref=Rhea:RHEA:21284, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.105; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21285; Evidence=; Sarcoplasmic reticulum membrane te=The N-terminus region encompasses a short hydrophobic sequence bound to the sarcoplasmic reticulum membrane, whereas the C-terminus catalytic domain faces the myoplasm. In skeletal muscle, enriched in the longitudinal sarcoplasmic reticulum (PubMed:21995425). Expressed in skeletal muscle and cardiac muscle (PubMed:21995425, PubMed:22143674, PubMed:27806939). Also expressed in liver, kidney, adipocytes and skin (PubMed:21995425, PubMed:22143674). In skeletal muscle, expressed in differentiated myotubes but not in undifferentiated myoblasts. Induced by all-trans-retinoic acid (at transcriptional level). The N-terminus region encompasses a short hydrophobic sequence bound to the sarcoplasmic reticulum membrane, whereas the C-terminus catalytic domain faces the myoplasm. Belongs to the short-chain dehydrogenases/reductases (SDR) family. retinol dehydrogenase activity extracellular region regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum longitudinal sarcoplasmic reticulum oxidoreductase activity sarcoplasmic reticulum membrane oxidation-reduction process uc011xwp.1 uc011xwp.2 uc011xwp.3 
ENSMUST00000168615.8 Rlf ENSMUST00000168615.8 May be involved in transcriptional regulation. (from UniProt E9Q532) AK132452 E9Q532 E9Q532_MOUSE ENSMUST00000168615.1 ENSMUST00000168615.2 ENSMUST00000168615.3 ENSMUST00000168615.4 ENSMUST00000168615.5 ENSMUST00000168615.6 ENSMUST00000168615.7 Rlf uc008uoa.1 uc008uoa.2 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding cellular_component DNA integration regulation of DNA methylation chromosome organization histone H3-K4 monomethylation uc008uoa.1 uc008uoa.2 
ENSMUST00000168625.2 Gm17108 ENSMUST00000168625.2 Gm17108 (from geneSymbol) AK019597 ENSMUST00000168625.1 uc288oim.1 uc288oim.2 uc288oim.1 uc288oim.2 
ENSMUST00000168630.4 Unc5d ENSMUST00000168630.4 unc-5 netrin receptor D, transcript variant 1 (from RefSeq NM_153135.3) B9EHC0 ENSMUST00000168630.1 ENSMUST00000168630.2 ENSMUST00000168630.3 NM_153135 Q8K1S2 UNC5D_MOUSE Unc5h4 uc009liz.1 uc009liz.2 uc009liz.3 Receptor for the netrin NTN4 that promotes neuronal cell survival (PubMed:21216843). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration (By similarity). Plays a role in the regulation of neuronal cell migration in the developing brain via its interaction with FLRT2 (PubMed:21673655). Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:21673655). May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (PubMed:26235030). Interacts (via extracellular domain) with FLRT2 and FLRT3 (via extracellular domain); the interaction is direct (PubMed:19492039, PubMed:21673655, PubMed:25374360, PubMed:26235030). Has higher affinity for FLRT2 (PubMed:25374360). Identified in a complex with FLRT3 and ADGRL3; does not interact with ADGRL3 by itself (PubMed:26235030). Cell membrane ingle-pass type I membrane protein Detected in multipolar cells in the brain subventricular zone (at protein level) (PubMed:18547816). Detected in embryonic brain neocortex, especially in the subventricular zone (PubMed:21673655). Detected in multipolar cells in the brain subventricular zone (PubMed:18547816). Detected in brain neocortex from young pups, especially in the somatosensory cortex (PubMed:21216843). Expressed in developing limb and mammary gland (PubMed:12351186). Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity). No visible phenotype. Mice are viable, appear healthy, and do not display any obvious behavorial defects. Cortical neurons from mutant mice display impaired axon growth cone collapse in response to Flrt2 and a tendency towards accelerated radial migration in the developing brain. Belongs to the unc-5 family. netrin receptor activity protein binding plasma membrane apoptotic process signal transduction multicellular organism development axon guidance cell surface membrane integral component of membrane pyramidal neuron differentiation netrin-activated signaling pathway cell-cell adhesion via plasma-membrane adhesion molecules regulation of neuron migration uc009liz.1 uc009liz.2 uc009liz.3 
ENSMUST00000168645.8 Phc3 ENSMUST00000168645.8 polyhomeotic 3, transcript variant 2 (from RefSeq NM_153421.2) A2RTJ9 ENSMUST00000168645.1 ENSMUST00000168645.2 ENSMUST00000168645.3 ENSMUST00000168645.4 ENSMUST00000168645.5 ENSMUST00000168645.6 ENSMUST00000168645.7 NM_153421 PHC3_MOUSE Q3TLV5 Q8CHP6 uc008ovl.1 uc008ovl.2 uc008ovl.3 uc008ovl.4 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Component of a PRC1-like complex. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CHP6-1; Sequence=Displayed; Name=2; IsoId=Q8CHP6-2; Sequence=VSP_016772, VSP_016773, VSP_016774, VSP_016775; Ubiquitous expression. molecular_function DNA binding nucleus multicellular organism development biological_process zinc ion binding PcG protein complex PRC1 complex metal ion binding uc008ovl.1 uc008ovl.2 uc008ovl.3 uc008ovl.4 
ENSMUST00000168665.3 2300009A05Rik ENSMUST00000168665.3 RIKEN cDNA 2300009A05 gene (from RefSeq NM_027090.1) CO061_MOUSE ENSMUST00000168665.1 ENSMUST00000168665.2 NM_027090 Q0VG49 Q3TYQ8 uc009qba.1 uc009qba.2 uc009qba.3 uc009qba.4 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0VG49-1; Sequence=Displayed; Name=2; IsoId=Q0VG49-2; Sequence=VSP_038577; Sequence=BAE34504.1; Type=Frameshift; Evidence=; molecular_function cellular_component extracellular region biological_process uc009qba.1 uc009qba.2 uc009qba.3 uc009qba.4 
ENSMUST00000168666.3 Prr22 ENSMUST00000168666.3 proline rich 22 (from RefSeq NM_001195673.1) ENSMUST00000168666.1 ENSMUST00000168666.2 F6TNE3 F6TNE3_MOUSE NM_001195673 Prr22 uc012avy.1 uc012avy.2 molecular_function cellular_component biological_process uc012avy.1 uc012avy.2 
ENSMUST00000168673.2 Gm3573 ENSMUST00000168673.2 Gm3573 (from geneSymbol) ENSMUST00000168673.1 Gm3573 L7N292 L7N292_MOUSE uc288spc.1 uc288spc.2 molecular_function cellular_component biological_process uc288spc.1 uc288spc.2 
ENSMUST00000168680.2 Myh15 ENSMUST00000168680.2 myosin, heavy chain 15 (from RefSeq NM_001166210.2) E9Q264 E9Q264_MOUSE ENSMUST00000168680.1 Myh15 NM_001166210 uc012agk.1 uc012agk.2 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. nucleotide binding extraocular skeletal muscle development motor activity actin binding ATP binding biological_process myosin complex actin filament binding uc012agk.1 uc012agk.2 
ENSMUST00000168686.3 Gm17207 ENSMUST00000168686.3 Gm17207 (from geneSymbol) ENSMUST00000168686.1 ENSMUST00000168686.2 KY468047 uc057lmj.1 uc057lmj.2 uc057lmj.3 uc057lmj.1 uc057lmj.2 uc057lmj.3 
ENSMUST00000168709.3 Gm20460 ENSMUST00000168709.3 Gm20460 (from geneSymbol) BC052330 ENSMUST00000168709.1 ENSMUST00000168709.2 uc289kfd.1 uc289kfd.2 uc289kfd.1 uc289kfd.2 
ENSMUST00000168710.3 Vmn2r97 ENSMUST00000168710.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N6Z2) ENSMUST00000168710.1 ENSMUST00000168710.2 K7N6Z2 K7N6Z2_MOUSE Vmn2r97 uc009vbc.1 uc009vbc.2 uc009vbc.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vbc.1 uc009vbc.2 uc009vbc.3 
ENSMUST00000168720.8 Cnppd1 ENSMUST00000168720.8 Membrane ; Single-pass membrane protein (from UniProt Q8K158) AK159252 CNPD1_MOUSE ENSMUST00000168720.1 ENSMUST00000168720.2 ENSMUST00000168720.3 ENSMUST00000168720.4 ENSMUST00000168720.5 ENSMUST00000168720.6 ENSMUST00000168720.7 Q3TE87 Q8K158 uc007bnr.1 uc007bnr.2 uc007bnr.3 Membrane ; Single-pass membrane protein Belongs to the CNPPD1 family. regulation of cyclin-dependent protein serine/threonine kinase activity molecular_function cellular_component biological_process membrane integral component of membrane protein kinase binding uc007bnr.1 uc007bnr.2 uc007bnr.3 
ENSMUST00000168727.3 Gdf10 ENSMUST00000168727.3 growth differentiation factor 10 (from RefSeq NM_145741.3) Bmp3b ENSMUST00000168727.1 ENSMUST00000168727.2 GDF10_MOUSE Gdf10 NM_145741 P97737 Q6PE07 uc007tab.1 uc007tab.2 uc007tab.3 uc007tab.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein has been shown to promote neural repair after stroke and may act as a tumor suppressor. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK042684.1, L42114.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway (PubMed:22155034). Plays an inhibitory role in the process of adipogenesis (PubMed:21712809). Homodimer or heterodimer. Can form a non-covalent complex of the mature region and the pro-region (PubMed:21712809). Secreted Highly expressed in epididymal adipose tissue, brain, bone and aorta and to a lesser extent in liver and spleen. Expressed at higher levels in preadipocytes than in mature adipocytes (PubMed:21712809). Strongly expressed in glial cells of the cerebellum (PubMed:24963847). During embryogenes is expressed most prominently in developing skeletal structures both in the craniofacial region and in the vertebral column. No visible phenotype. 3T3-L1 cells endogenously secrete biologically active Gdf10 as a unique complex that contains both the pro-region and the mature region. Belongs to the TGF-beta family. ossification osteoblast differentiation cytokine activity transforming growth factor beta receptor binding extracellular region extracellular space growth factor activity positive regulation of pathway-restricted SMAD protein phosphorylation BMP signaling pathway regulation of apoptotic process regulation of MAPK cascade fat cell differentiation negative regulation of osteoblast differentiation positive regulation of osteoblast differentiation cell development SMAD protein signal transduction uc007tab.1 uc007tab.2 uc007tab.3 uc007tab.4 
ENSMUST00000168729.8 Tgm1 ENSMUST00000168729.8 transglutaminase 1, K polypeptide, transcript variant 1 (from RefSeq NM_001161715.1) A0A0R4J293 A0A0R4J293_MOUSE ENSMUST00000168729.1 ENSMUST00000168729.2 ENSMUST00000168729.3 ENSMUST00000168729.4 ENSMUST00000168729.5 ENSMUST00000168729.6 ENSMUST00000168729.7 NM_001161715 Tgm1 uc011zln.1 uc011zln.2 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Interacts with PLAAT4. Membrane ; Lipid- anchor Belongs to the transglutaminase superfamily. Transglutaminase family. protein-glutamine gamma-glutamyltransferase activity positive regulation of keratinocyte proliferation membrane peptide cross-linking keratinocyte differentiation intrinsic component of membrane positive regulation of cell cycle metal ion binding uc011zln.1 uc011zln.2 
ENSMUST00000168730.3 Vmn2r67 ENSMUST00000168730.3 vomeronasal 2, receptor 67 (from RefSeq NM_001102579.1) ENSMUST00000168730.1 ENSMUST00000168730.2 K7N6T2 K7N6T2_MOUSE NM_001102579 Vmn2r67 uc009vem.1 uc009vem.2 uc009vem.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vem.1 uc009vem.2 uc009vem.3 
ENSMUST00000168747.3 Atp10a ENSMUST00000168747.3 ATPase, class V, type 10A (from RefSeq NM_009728.2) Atp10a ENSMUST00000168747.1 ENSMUST00000168747.2 NM_009728 Q3V1Y7 Q3V1Y7_MOUSE uc009hef.1 uc009hef.2 uc009hef.3 uc009hef.4 Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Membrane ulti-pass membrane protein Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. nucleotide binding magnesium ion binding ATP binding endoplasmic reticulum phospholipid transport membrane integral component of membrane uc009hef.1 uc009hef.2 uc009hef.3 uc009hef.4 
ENSMUST00000168767.9 Ramacl ENSMUST00000168767.9 Nucleus (from UniProt Q3TQP0) AK139034 ENSMUST00000168767.1 ENSMUST00000168767.2 ENSMUST00000168767.3 ENSMUST00000168767.4 ENSMUST00000168767.5 ENSMUST00000168767.6 ENSMUST00000168767.7 ENSMUST00000168767.8 Gm10767 Q3TQP0 Q3TQP0_MOUSE Ramacl uc007qzv.1 uc007qzv.2 uc007qzv.3 Nucleus Belongs to the RAM family. molecular_function RNA binding cellular_component mRNA cap binding complex biological_process uc007qzv.1 uc007qzv.2 uc007qzv.3 
ENSMUST00000168769.3 Alyreffm5 ENSMUST00000168769.3 predicted gene 4302 (from RefSeq NM_001166634.1) B2RY52 B2RY52_MOUSE E9PX25 EG667568 ENSMUST00000168769.1 ENSMUST00000168769.2 Gm4302 NM_001166634 uc033fsj.1 uc033fsj.2 uc033fsj.3 molecular_function nucleic acid binding RNA binding cellular_component biological_process uc033fsj.1 uc033fsj.2 uc033fsj.3 
ENSMUST00000168779.3 2210408I21Rik ENSMUST00000168779.3 RIKEN cDNA 2210408I21 gene, transcript variant 1 (from RefSeq NM_001145676.2) E9Q2V0 ENSMUST00000168779.1 ENSMUST00000168779.2 K0825_MOUSE NM_001145676 Q3TPR6 Q3UPC7 Q5FWD2 Q8BQF4 Q9D7T8 uc007rgx.1 uc007rgx.2 uc007rgx.3 uc007rgx.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UPC7-1; Sequence=Displayed; Name=2; IsoId=Q3UPC7-2; Sequence=VSP_039419, VSP_039420; Sequence=BAB25933.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAB25933.1; Type=Frameshift; Evidence=; Sequence=BAC34444.1; Type=Frameshift; Evidence=; Sequence=BAE37669.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cellular_component biological_process uc007rgx.1 uc007rgx.2 uc007rgx.3 uc007rgx.4 
ENSMUST00000168787.8 Btbd9 ENSMUST00000168787.8 BTB domain containing 9, transcript variant 2 (from RefSeq NM_172618.2) BTBD9_MOUSE ENSMUST00000168787.1 ENSMUST00000168787.2 ENSMUST00000168787.3 ENSMUST00000168787.4 ENSMUST00000168787.5 ENSMUST00000168787.6 ENSMUST00000168787.7 NM_172618 Q8C726 uc008btt.1 uc008btt.2 uc008btt.3 uc008btt.4 Expressed in the brain (at protein level). long-term memory adult locomotory behavior serotonin metabolic process circadian sleep/wake cycle, non-REM sleep circadian behavior sensory perception of temperature stimulus multicellular organismal iron ion homeostasis regulation of synaptic vesicle endocytosis uc008btt.1 uc008btt.2 uc008btt.3 uc008btt.4 
ENSMUST00000168807.3 Vmn2r41 ENSMUST00000168807.3 vomeronasal 2, receptor 41 (from RefSeq NM_001105073.1) E9Q5C7 E9Q5C7_MOUSE ENSMUST00000168807.1 ENSMUST00000168807.2 NM_001105073 Vmn2r41 uc012eyi.1 uc012eyi.2 uc012eyi.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012eyi.1 uc012eyi.2 uc012eyi.3 
ENSMUST00000168828.3 Zfp385a ENSMUST00000168828.3 zinc finger protein 385A, transcript variant 1 (from RefSeq NM_013866.3) ENSMUST00000168828.1 ENSMUST00000168828.2 G3UWA5 Hzf NM_013866 Q8VD12 Q9QY68 Z385A_MOUSE Znf385a uc007xya.1 uc007xya.2 uc007xya.3 RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'- UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell- cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. Interacts with p53/TP53; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest. Interacts with ELAVL1; the interaction is indirect, mRNA-dependent and may regulate p53/TP53 expression. Cytoplasm Nucleus, nucleolus Cell projection, dendrite Note=Detected in dendrites of Purkinje cells and hippocampal neurons. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VD12-1; Sequence=Displayed; Name=2; IsoId=Q8VD12-2; Sequence=VSP_047450; Expressed in brain and testis (at protein level). In brain, the expression is located to olfactory bulb, cerebral cortex, hippocampus, satellite cells and Purkinje cells of the cerebellum molecular layer. Detected in bone marrow, white and brown adipose tissue, lung and at lower levels in the thymus. At 14.5 dpc, expressed in large polynucleated cells within the liver. Induced during adipogenesis. By p53/TP53 in response to DNA damage. Ubiquitinated upon prolonged exposure to genotoxic stress, which leads to proteasomal degradation of ZNF385A and releases p53/TP53 from cell-cycle arrest target gene promoters. No visible phenotype at birth. Between 2-3 weeks after birth, some lethality is observed, may be due to internal hemorrhaging mainly in brain and gastrointestinal tracts. Surviving mutants are fertile and smaller than their wild-type littermates. Deficiency alters hemostasis which is associated with a block in the formation of alpha-granules in megakaryocytes and abnormal platelet morphology. Mice also exhibit tremor, ataxic gate, tilted head, severe impairments in motor coordination and motor learning related to cerebellar functions. Mice show functional deregulation of adipose tissues, although the total fat mass is not affected. They express lower levels of C/EBP alpha in adipose tissue, have impaired glucose tolerance with high plasma insulin levels and plasma adiponectin levels are significantly lower. Upon genotoxic stress, skin and prostate show increased apoptosis. Sequence=AAF24093.1; Type=Frameshift; Evidence=; nuclear chromatin p53 binding nucleic acid binding RNA binding mRNA 3'-UTR binding nucleus nucleolus cytoplasm regulation of translation apoptotic process cellular response to DNA damage stimulus cell cycle hemostasis learning or memory locomotory behavior zinc ion binding intracellular mRNA localization mRNA localization resulting in posttranscriptional regulation of gene expression platelet formation dendrite megakaryocyte development cell projection neuronal cell body positive regulation of fat cell differentiation metal ion binding platelet alpha granule organization positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of cytoplasmic translation uc007xya.1 uc007xya.2 uc007xya.3 
ENSMUST00000168838.3 Cyp2c69 ENSMUST00000168838.3 cytochrome P450, family 2, subfamily c, polypeptide 69 (from RefSeq NM_001104525.1) Cyp2c69 E9PXC3 E9PXC3_MOUSE ENSMUST00000168838.1 ENSMUST00000168838.2 NM_001104525 uc009vby.1 uc009vby.2 uc009vby.3 Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc009vby.1 uc009vby.2 uc009vby.3 
ENSMUST00000168843.2 Gm4925 ENSMUST00000168843.2 Gm4925 (from geneSymbol) ENSMUST00000168843.1 uc011xlj.1 uc011xlj.2 uc011xlj.3 uc011xlj.1 uc011xlj.2 uc011xlj.3 
ENSMUST00000168844.9 Dis3l ENSMUST00000168844.9 DIS3 like exosome 3'-5' exoribonuclease, transcript variant 1 (from RefSeq NM_001001295.2) DI3L1_MOUSE ENSMUST00000168844.1 ENSMUST00000168844.2 ENSMUST00000168844.3 ENSMUST00000168844.4 ENSMUST00000168844.5 ENSMUST00000168844.6 ENSMUST00000168844.7 ENSMUST00000168844.8 Kiaa1955 NM_001001295 Q69Z56 Q8C0S1 uc009qbw.1 uc009qbw.2 uc009qbw.3 Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.13.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C0S1-1; Sequence=Displayed; Name=2; IsoId=Q8C0S1-2; Sequence=VSP_030370; Belongs to the RNR ribonuclease family. Sequence=AAH56939.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32588.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; 3'-5'-exoribonuclease activity cytoplasmic exosome (RNase complex) exosome (RNase complex) RNA binding nuclease activity exonuclease activity ribonuclease activity cytoplasm centrosome cytosol plasma membrane rRNA catabolic process hydrolase activity enzyme binding RNA phosphodiester bond hydrolysis, exonucleolytic uc009qbw.1 uc009qbw.2 uc009qbw.3 
ENSMUST00000168846.3 Prkag1 ENSMUST00000168846.3 protein kinase, AMP-activated, gamma 1 non-catalytic subunit, transcript variant 1 (from RefSeq NM_016781.3) ENSMUST00000168846.1 ENSMUST00000168846.2 NM_016781 Prkag1 Q3TWR3 Q3TWR3_MOUSE uc007xoa.1 uc007xoa.2 uc007xoa.3 AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2. Belongs to the 5'-AMP-activated protein kinase gamma subunit family. protein kinase activity protein phosphorylation positive regulation of gene expression protein kinase binding adenyl ribonucleotide binding regulation of protein serine/threonine kinase activity uc007xoa.1 uc007xoa.2 uc007xoa.3 
ENSMUST00000168875.8 Gm1979 ENSMUST00000168875.8 predicted gene 1979 (from RefSeq NM_001281519.1) E9QAN3 E9QAN3_MOUSE ENSMUST00000168875.1 ENSMUST00000168875.2 ENSMUST00000168875.3 ENSMUST00000168875.4 ENSMUST00000168875.5 ENSMUST00000168875.6 ENSMUST00000168875.7 Gm1979 NM_001281519 uc033iia.1 uc033iia.2 uc033iia.3 molecular_function cellular_component biological_process uc033iia.1 uc033iia.2 uc033iia.3 
ENSMUST00000168884.8 Hpn ENSMUST00000168884.8 hepsin, transcript variant 2 (from RefSeq NM_008281.4) ENSMUST00000168884.1 ENSMUST00000168884.2 ENSMUST00000168884.3 ENSMUST00000168884.4 ENSMUST00000168884.5 ENSMUST00000168884.6 ENSMUST00000168884.7 G3UWE8 G3UWE8_MOUSE Hpn NM_008281 uc009gic.1 uc009gic.2 uc009gic.3 uc009gic.4 uc009gic.5 This gene encodes a type II transmembrane serine protease that may function in diverse processes, including regulation of cell growth. Deficiency in this gene results in hearing loss. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity membrane hydrolase activity serine-type exopeptidase activity uc009gic.1 uc009gic.2 uc009gic.3 uc009gic.4 uc009gic.5 
ENSMUST00000168889.3 Diaph3 ENSMUST00000168889.3 diaphanous related formin 3 (from RefSeq NM_019670.2) DIAP3_MOUSE Diap3 ENSMUST00000168889.1 ENSMUST00000168889.2 NM_019670 Q9Z207 uc007uub.1 uc007uub.2 uc007uub.3 Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (PubMed:10678165, PubMed:23558171). Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor (PubMed:10678165, PubMed:23558171). Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization (PubMed:10678165). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (PubMed:10678165). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (PubMed:23558171). Q9Z207; Q8CBW3: Abi1; NbExp=2; IntAct=EBI-6550123, EBI-375511; Cytoplasm cleus te=During mitosis, co-localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis (By similarity). Shuttles between the cytoplasm and the nucleus (PubMed:19117945). Increased expression in S phase and mitotic cells; levels decrease as cells enter in G0/G1 phase due to proteasomal degradation (at protein level). The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain (PubMed:23558171). This autoinhibition is released upon competitive binding of an activated GTPase (PubMed:23558171). The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (PubMed:23558171). Ubiquitinated. Belongs to the formin homology family. Diaphanous subfamily. actin binding protein binding nucleus cytoplasm cytoskeleton organization cellular component organization Rho GTPase binding actin cytoskeleton organization actin filament polymerization uc007uub.1 uc007uub.2 uc007uub.3 
ENSMUST00000168890.2 Nrep ENSMUST00000168890.2 neuronal regeneration related protein, transcript variant 2 (from RefSeq NM_001109988.1) D0H4S114 ENSMUST00000168890.1 Harp NM_001109988 Nrep Q542Q5 Q542Q5_MOUSE uc008eju.1 uc008eju.2 uc008eju.3 nucleus cytoplasm axon regeneration regulation of neuron differentiation uc008eju.1 uc008eju.2 uc008eju.3 
ENSMUST00000168897.2 Gm17103 ENSMUST00000168897.2 Gm17103 (from geneSymbol) ENSMUST00000168897.1 uc289eqa.1 uc289eqa.2 uc289eqa.1 uc289eqa.2 
ENSMUST00000168919.8 Klrk1 ENSMUST00000168919.8 killer cell lectin-like receptor subfamily K, member 1, transcript variant 3 (from RefSeq NM_001286018.1) ENSMUST00000168919.1 ENSMUST00000168919.2 ENSMUST00000168919.3 ENSMUST00000168919.4 ENSMUST00000168919.5 ENSMUST00000168919.6 ENSMUST00000168919.7 Klrk1 NM_001286018 Q3TCW7 Q3TCW7_MOUSE uc009egh.1 uc009egh.2 uc009egh.3 membrane integral component of membrane carbohydrate binding positive regulation of natural killer cell mediated cytotoxicity uc009egh.1 uc009egh.2 uc009egh.3 
ENSMUST00000168926.2 Vmn1r259 ENSMUST00000168926.2 vomeronasal 1 receptor 259 (from RefSeq NM_001167166.1) D3YTX3 D3YTX5 D3YTX5_MOUSE E9PW84 E9PYZ9 E9Q018 E9Q3T1 E9Q3V4 E9Q4Q4 E9Q5H4 E9Q8U4 ENSMUST00000168926.1 Gm4177 Gm4216 NM_001167166 Vmn1r248 Vmn1r259 uc012fen.1 uc012fen.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fen.1 uc012fen.2 
ENSMUST00000168951.2 Gm17058 ENSMUST00000168951.2 Gm17058 (from geneSymbol) ENSMUST00000168951.1 uc289bhw.1 uc289bhw.2 uc289bhw.1 uc289bhw.2 
ENSMUST00000168953.3 ENSMUSG00000094383 ENSMUST00000168953.3 ENSMUSG00000094383 (from geneSymbol) ENSMUST00000168953.1 ENSMUST00000168953.2 uc291cfl.1 uc291cfl.2 uc291cfl.1 uc291cfl.2 
ENSMUST00000168977.8 Ylpm1 ENSMUST00000168977.8 YLP motif containing 1, transcript variant 2 (from RefSeq NM_001347421.1) E9Q803 E9Q803_MOUSE ENSMUST00000168977.1 ENSMUST00000168977.2 ENSMUST00000168977.3 ENSMUST00000168977.4 ENSMUST00000168977.5 ENSMUST00000168977.6 ENSMUST00000168977.7 NM_001347421 Ylpm1 uc007oge.1 uc007oge.2 uc007oge.3 nucleus uc007oge.1 uc007oge.2 uc007oge.3 
ENSMUST00000168978.3 Gm20427 ENSMUST00000168978.3 Gm20427 (from geneSymbol) AK169702 ENSMUST00000168978.1 ENSMUST00000168978.2 uc029thc.1 uc029thc.2 uc029thc.3 uc029thc.4 uc029thc.1 uc029thc.2 uc029thc.3 uc029thc.4 
ENSMUST00000168984.2 Vmn1r95 ENSMUST00000168984.2 vomeronasal 1 receptor, 95 (from RefSeq NM_001167538.1) E9PUW9 E9PUW9_MOUSE ENSMUST00000168984.1 NM_001167538 Vmn1r143 Vmn1r95 uc012fbr.1 uc012fbr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fbr.1 uc012fbr.2 
ENSMUST00000168989.9 Kctd1 ENSMUST00000168989.9 potassium channel tetramerisation domain containing 1, transcript variant 1 (from RefSeq NM_001142731.1) E9Q6T9 E9Q6T9_MOUSE ENSMUST00000168989.1 ENSMUST00000168989.2 ENSMUST00000168989.3 ENSMUST00000168989.4 ENSMUST00000168989.5 ENSMUST00000168989.6 ENSMUST00000168989.7 ENSMUST00000168989.8 Kctd1 NM_001142731 uc008edn.1 uc008edn.2 uc008edn.3 uc008edn.4 protein homooligomerization uc008edn.1 uc008edn.2 uc008edn.3 uc008edn.4 
ENSMUST00000168990.2 Gm17034 ENSMUST00000168990.2 Gm17034 (from geneSymbol) AK084864 ENSMUST00000168990.1 uc291gat.1 uc291gat.2 uc291gat.1 uc291gat.2 
ENSMUST00000168997.2 Krtap10-21 ENSMUST00000168997.2 predicted gene 3233 (from RefSeq NM_001370831.1) E9Q2H5 E9Q2H5_MOUSE ENSMUST00000168997.1 Gm3233 NM_001370831 uc287sml.1 uc287sml.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc287sml.1 uc287sml.2 
ENSMUST00000169020.8 Glg1 ENSMUST00000169020.8 golgi apparatus protein 1, transcript variant 2 (from RefSeq NM_009149.3) ENSMUST00000169020.1 ENSMUST00000169020.2 ENSMUST00000169020.3 ENSMUST00000169020.4 ENSMUST00000169020.5 ENSMUST00000169020.6 ENSMUST00000169020.7 Esl1 GSLG1_MOUSE Mg160 NM_009149 Q61543 Q9QZ40 Selel uc009nma.1 uc009nma.2 uc009nma.3 uc009nma.4 Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). Cell membrane ; Single-pass type I membrane protein Golgi apparatus membrane ; Single-pass type I membrane protein Golgi outpost Cytoplasm, cytoskeleton, microtubule organizing center Note=Golgi and microvilli on the cell surface (PubMed:9099943). Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity). Widely expressed; found in myeloid cells, fibroblasts, colon carcinoma, endothelioma, teratocarcinoma, lymphoma, myeloma. Fucosylation is essential for binding to E-selectin. Contains sialic acid residues. Golgi membrane Golgi apparatus Golgi medial cisterna plasma membrane negative regulation of protein processing membrane integral component of membrane fibroblast growth factor binding negative regulation of transforming growth factor beta receptor signaling pathway extracellular matrix regulation of chondrocyte differentiation intracellular membrane-bounded organelle bone morphogenesis uc009nma.1 uc009nma.2 uc009nma.3 uc009nma.4 
ENSMUST00000169032.8 Idh1 ENSMUST00000169032.8 isocitrate dehydrogenase 1 (NADP+), soluble, transcript variant 1 (from RefSeq NM_001111320.1) ENSMUST00000169032.1 ENSMUST00000169032.2 ENSMUST00000169032.3 ENSMUST00000169032.4 ENSMUST00000169032.5 ENSMUST00000169032.6 ENSMUST00000169032.7 IDHC_MOUSE NM_001111320 O88844 Q3UAV7 uc011wmj.1 uc011wmj.2 uc011wmj.3 Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:12031902, PubMed:29923039). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:12031902). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity). Reaction=D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH; Xref=Rhea:RHEA:19629, ChEBI:CHEBI:15562, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.42; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19630; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit. ; Irreversibly inhibited by Cd(2+) concentrations above 50 uM. Homodimer. Cytoplasm, cytosol Highly expressed in the liver followed by kidney, lower expression in spleen, brain and lung. Acetylation at Lys-374 dramatically reduces catalytic activity. Belongs to the isocitrate and isopropylmalate dehydrogenases family. magnesium ion binding isocitrate dehydrogenase activity isocitrate dehydrogenase (NADP+) activity cytoplasm mitochondrion peroxisome cytosol glyoxylate cycle tricarboxylic acid cycle isocitrate metabolic process 2-oxoglutarate metabolic process NADP metabolic process glutathione metabolic process response to oxidative stress female gonad development response to organic cyclic compound oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor identical protein binding protein homodimerization activity metal ion binding response to steroid hormone NADP binding NAD binding oxidation-reduction process regulation of phospholipid catabolic process regulation of phospholipid biosynthetic process uc011wmj.1 uc011wmj.2 uc011wmj.3 
ENSMUST00000169037.9 Adcy7 ENSMUST00000169037.9 adenylate cyclase 7, transcript variant 1 (from RefSeq NM_007406.2) ADCY7_MOUSE Adcy7 ENSMUST00000169037.1 ENSMUST00000169037.2 ENSMUST00000169037.3 ENSMUST00000169037.4 ENSMUST00000169037.5 ENSMUST00000169037.6 ENSMUST00000169037.7 ENSMUST00000169037.8 NM_007406 P51829 Q3U3P2 uc009mrh.1 uc009mrh.2 uc009mrh.3 uc009mrh.4 Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (PubMed:23178822). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (By similarity). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (PubMed:20505140). Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro). ; Activated by the G protein alpha subunit. Activated by the G protein beta and gamma subunit complex. Activated by GNA13 and GNA12. Ethanol and phorbol 12,13-dibutanoate significantly potentiate adenylate cyclase activity generated in response to the activation of the prostanoid receptor by the agonist prostaglandin E1(1-) in a PKC-dependent manner (By similarity). Inhibited by lithium (PubMed:18205980). Membrane; Multi-pass membrane protein. Most abundant in heart, spleen and lung. The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate- binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain. Phosphorylated by PRKCD. Knockout Adcy7 homozygous mice die during embryogenesis (more than 93%). To obtain adult animals with Adcy7- deficient immune systems, the hematopoietic stem cells obtained from the rare adult Adcy7 homozygous mice are transplanted into lethally irradiated wild-type animals. All chimeric mice survived the transplant procedure and appeared healthy. Adcy7-deficient mice appear to be hypersensitive to lipopolysaccharide-induced endotoxic shock and display a higher mortality rate. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding regulation of adaptive immune response adenylate cyclase activity ATP binding plasma membrane integral component of plasma membrane cAMP biosynthetic process adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity cyclic nucleotide biosynthetic process membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity intracellular signal transduction metal ion binding maternal process involved in female pregnancy cellular response to lithium ion cellular response to ethanol negative regulation of cytokine production involved in inflammatory response uc009mrh.1 uc009mrh.2 uc009mrh.3 uc009mrh.4 
ENSMUST00000169041.9 Misp ENSMUST00000169041.9 mitotic spindle positioning (from RefSeq NM_030218.2) ENSMUST00000169041.1 ENSMUST00000169041.2 ENSMUST00000169041.3 ENSMUST00000169041.4 ENSMUST00000169041.5 ENSMUST00000169041.6 ENSMUST00000169041.7 ENSMUST00000169041.8 MISP_MOUSE Misp NM_030218 Q3UI04 Q9D279 uc007fzy.1 uc007fzy.2 uc007fzy.3 Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytoskeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus (By similarity). Associates with F-actin. Interacts with DCTN1; this interaction regulates DCTN1 distribution at the cell cortex. Interacts with PTK2/FAK and MAPRE1 (By similarity). Cell junction, focal adhesion Cytoplasm, cytoskeleton Cytoplasm, cell cortex Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis (By similarity). Phosphorylated by CDK1 and PLK1. CDK1 is the priming kinase for PLK1 phosphorylation. Phosphorylation by PLK1 is required for proper spindle orientation at metaphase (By similarity). Belongs to the MISP family. establishment of mitotic spindle orientation actin binding cytoplasm cytoskeleton actin filament plasma membrane adherens junction focal adhesion cell cortex cell cycle cell migration cell junction cortical actin cytoskeleton spindle pole centrosome intracellular membrane-bounded organelle actin filament binding cell division organelle localization establishment of centrosome localization mitotic spindle assembly regulation of protein localization to cell cortex mitotic spindle astral microtubule end uc007fzy.1 uc007fzy.2 uc007fzy.3 
ENSMUST00000169054.3 A430057M04Rik ENSMUST00000169054.3 A430057M04Rik (from geneSymbol) AK079754 ENSMUST00000169054.1 ENSMUST00000169054.2 uc007slu.1 uc007slu.2 uc007slu.3 uc007slu.1 uc007slu.2 uc007slu.3 
ENSMUST00000169061.8 Drosha ENSMUST00000169061.8 drosha, ribonuclease type III, transcript variant 2 (from RefSeq NM_026799.3) ENSMUST00000169061.1 ENSMUST00000169061.2 ENSMUST00000169061.3 ENSMUST00000169061.4 ENSMUST00000169061.5 ENSMUST00000169061.6 ENSMUST00000169061.7 Etohi2 NM_026799 Q5HZJ0 RNC_MOUSE Rn3 Rnasen uc007via.1 uc007via.2 uc007via.3 uc007via.4 Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri- miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26255770). Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.3; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Each RNase III domain binds at least one Mg(2+) or Mn(2+) ion. ; Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8 (By similarity). The microprocessor complex is a heterotrimer; each of the two DROSHA RNase III domains binds one DGCR8 (via C-terminal region) (By similarity). Interacts with SP1 and SNIP1 (By similarity). Interacts with SRRT/ARS2 (PubMed:19632182). Interacts with CPSF3 and ISY1; this interaction is in an RNA dependent manner (PubMed:26255770). Interacts with PUS10; interaction promotes pri-miRNAs processing (By similarity). Nucleus Nucleus, nucleolus Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies. The 2 RNase III domains form an intramolecular dimer where the domain 1 cuts the 3'strand while the domain 2 cleaves the 5'strand of pri-miRNAs, independently of each other. Belongs to the ribonuclease III family. lipopolysaccharide binding RNA binding double-stranded RNA binding nuclease activity endonuclease activity endoribonuclease activity ribonuclease III activity protein binding nucleus nucleolus RNA processing regulation of gene expression miRNA metabolic process positive regulation of gene expression postsynaptic density rRNA catabolic process hydrolase activity DEAD/H-box RNA helicase binding production of siRNA involved in RNA interference primary miRNA processing pre-miRNA processing ribosome biogenesis protein homodimerization activity regulation of regulatory T cell differentiation SMAD binding metal ion binding regulation of inflammatory response defense response to Gram-negative bacterium defense response to Gram-positive bacterium R-SMAD binding microprocessor complex primary miRNA binding nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic regulation of miRNA metabolic process uc007via.1 uc007via.2 uc007via.3 uc007via.4 
ENSMUST00000169070.2 Ear6 ENSMUST00000169070.2 Belongs to the pancreatic ribonuclease family. (from UniProt Q923L7) BC147697 ENSMUST00000169070.1 Ear6 Q923L7 Q923L7_MOUSE uc011zkd.1 uc011zkd.2 uc011zkd.3 Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity ribonuclease activity cellular_component hydrolase activity nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis uc011zkd.1 uc011zkd.2 uc011zkd.3 
ENSMUST00000169079.8 Lrrcc1 ENSMUST00000169079.8 leucine rich repeat and coiled-coil domain containing 1, transcript variant 1 (from RefSeq NM_001163579.1) ENSMUST00000169079.1 ENSMUST00000169079.2 ENSMUST00000169079.3 ENSMUST00000169079.4 ENSMUST00000169079.5 ENSMUST00000169079.6 ENSMUST00000169079.7 G5E8Y2 G5E8Y2_MOUSE Lrrcc1 NM_001163579 uc008oqh.1 uc008oqh.2 uc008oqh.3 uc008oqh.4 centrosome uc008oqh.1 uc008oqh.2 uc008oqh.3 uc008oqh.4 
ENSMUST00000169082.3 Aqp5 ENSMUST00000169082.3 aquaporin 5 (from RefSeq NM_009701.4) AQP5_MOUSE ENSMUST00000169082.1 ENSMUST00000169082.2 NM_009701 Q545H1 Q9WTY4 uc007xpt.1 uc007xpt.2 uc007xpt.3 Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands (PubMed:10400615, PubMed:16571723, PubMed:18027168). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Seems to play a redundant role in water transport in the eye, lung and in sweat glands (PubMed:10619865, PubMed:12042359, PubMed:18027168). Homotetramer (By similarity). Interacts with TRPV4; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity (PubMed:16571723). Apical cell membrane ulti-pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Note=Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane. Detected at the luminal membrane of secretory epithelial cells in hindpaw sweat glands (PubMed:12042359, PubMed:23473857). Detected in acinar cells in salivary glands, in duct cells in lacrimal glands and in lung (at protein level) (PubMed:10337625, PubMed:10400615, PubMed:10619865, PubMed:16571723, PubMed:18027168). Detected in lung, parotid, submandibular, sublingual, and lacrimal gland tissues (PubMed:10337625). Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Homozygous mice are born at less than the expected Mendelian rate, indicative of embryonic lethality (PubMed:10400615, PubMed:10619865). After weaning, mice display decreased pilocarbine-induced saliva secretion, and their saliva displays increased osmolality and viscosity (PubMed:10400615, PubMed:18027168). Mice display reduced Ca2+ entry and loss of regulatory volume decrease in response to hypotonicity in acinar cells. HTS-stimulated Ca2+ entry is significantly decreased in submandibular gland acini and almost completely abolished in parotid acini (PubMed:16571723). Lung airspace-capillary osmotic water permeability is strongly decreased. In contrast, there is no change in alveolar fluid clearance (PubMed:10619865). Paws of mutant mice display normal sweat secretion (PubMed:12042359). Tear secretion is not changed in mutant mice (PubMed:18027168). Belongs to the MIP/aquaporin (TC 1.A.8) family. protein binding endoplasmic reticulum plasma membrane integral component of plasma membrane microvillus water transport basal plasma membrane water channel activity channel activity carbon dioxide transport membrane integral component of membrane apical plasma membrane pancreatic juice secretion cytoplasmic vesicle membrane cytoplasmic vesicle odontogenesis identical protein binding saliva secretion camera-type eye morphogenesis protein homotetramerization transmembrane transport cellular hypotonic response uc007xpt.1 uc007xpt.2 uc007xpt.3 
ENSMUST00000169094.8 G3bp2 ENSMUST00000169094.8 G3BP stress granule assembly factor 2, transcript variant 7 (from RefSeq NM_001359196.1) ENSMUST00000169094.1 ENSMUST00000169094.2 ENSMUST00000169094.3 ENSMUST00000169094.4 ENSMUST00000169094.5 ENSMUST00000169094.6 ENSMUST00000169094.7 G3bp2 NM_001359196 Q3U541 Q3U541_MOUSE uc008ych.1 uc008ych.2 uc008ych.3 uc008ych.4 nucleic acid binding RNA binding cytosol cytoplasmic stress granule stress granule assembly protein homooligomerization uc008ych.1 uc008ych.2 uc008ych.3 uc008ych.4 
ENSMUST00000169095.6 Cd36 ENSMUST00000169095.6 CD36 molecule, transcript variant 1 (from RefSeq NM_001159558.2) Cd36 ENSMUST00000169095.1 ENSMUST00000169095.2 ENSMUST00000169095.3 ENSMUST00000169095.4 ENSMUST00000169095.5 NM_001159558 Q3UAI3 Q3UAI3_MOUSE uc012dsl.1 uc012dsl.2 uc012dsl.3 Reaction=(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in); Xref=Rhea:RHEA:33655, ChEBI:CHEBI:30823; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33656; Evidence=; Reaction=(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)- octadecadienoate(in); Xref=Rhea:RHEA:45264, ChEBI:CHEBI:30245; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45265; Evidence=; Reaction=butanoate(out) = butanoate(in); Xref=Rhea:RHEA:45248, ChEBI:CHEBI:17968; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45249; Evidence=; Reaction=hexadecanoate(out) = hexadecanoate(in); Xref=Rhea:RHEA:45256, ChEBI:CHEBI:7896; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45257; Evidence=; Reaction=tetracosanoate(out) = tetracosanoate(in); Xref=Rhea:RHEA:45260, ChEBI:CHEBI:31014; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45261; Evidence=; Reaction=tetradecanoate(out) = tetradecanoate(in); Xref=Rhea:RHEA:45252, ChEBI:CHEBI:30807; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45253; Evidence=; Apical cell membrane Cell membrane Golgi apparatus Membrane raft Belongs to the CD36 family. beta-amyloid binding positive regulation of cell-matrix adhesion low-density lipoprotein receptor activity scavenger receptor activity cell Golgi apparatus plasma membrane receptor-mediated endocytosis immune response cell surface receptor signaling pathway nitric oxide mediated signal transduction lipid binding cell surface positive regulation of macrophage derived foam cell differentiation positive regulation of cell death membrane integral component of membrane lipid storage cGMP-mediated signaling low-density lipoprotein particle binding regulation of toll-like receptor signaling pathway low-density lipoprotein particle clearance Toll-like receptor binding lipoprotein transport receptor complex regulation of protein heterodimerization activity long-chain fatty acid import macromolecular complex binding membrane raft positive regulation of NF-kappaB transcription factor activity cellular response to diacyl bacterial lipopeptide lipoprotein particle binding cellular response to beta-amyloid uc012dsl.1 uc012dsl.2 uc012dsl.3 
ENSMUST00000169105.8 Myo18a ENSMUST00000169105.8 myosin XVIIIA, transcript variant 3 (from RefSeq NM_001291212.2) B2RRE2 B2RRE2_MOUSE ENSMUST00000169105.1 ENSMUST00000169105.2 ENSMUST00000169105.3 ENSMUST00000169105.4 ENSMUST00000169105.5 ENSMUST00000169105.6 ENSMUST00000169105.7 Myo18a NM_001291212 uc011xzx.1 uc011xzx.2 uc011xzx.3 uc011xzx.4 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Lacks conserved residue(s) required for the propagation of feature annotation. nucleotide binding motor activity actin binding ATP binding myosin complex actin filament binding uc011xzx.1 uc011xzx.2 uc011xzx.3 uc011xzx.4 
ENSMUST00000169114.3 Erap1 ENSMUST00000169114.3 endoplasmic reticulum aminopeptidase 1, transcript variant 1 (from RefSeq NM_030711.6) Appils Arts1 ENSMUST00000169114.1 ENSMUST00000169114.2 ERAP1_MOUSE NM_030711 Q6GTP5 Q9EQH2 Q9ET63 uc007rfj.1 uc007rfj.2 uc007rfj.3 Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX (By similarity). Endoplasmic reticulum membrane ; Single-pass type II membrane protein N-glycosylated. Belongs to the peptidase M1 family. adaptive immune response immune system process aminopeptidase activity interleukin-6 receptor binding tumor necrosis factor receptor binding extracellular region cytoplasm endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane proteolysis membrane protein ectodomain proteolysis regulation of blood pressure peptidase activity metalloexopeptidase activity metallopeptidase activity zinc ion binding membrane integral component of membrane hydrolase activity antigen processing and presentation of endogenous peptide antigen via MHC class I peptide binding peptide catabolic process intracellular membrane-bounded organelle positive regulation of angiogenesis metal ion binding metalloaminopeptidase activity uc007rfj.1 uc007rfj.2 uc007rfj.3 
ENSMUST00000169130.3 Vmn2r62 ENSMUST00000169130.3 vomeronasal 2, receptor 62 (from RefSeq NM_001105059.1) ENSMUST00000169130.1 ENSMUST00000169130.2 K7N712 K7N712_MOUSE NM_001105059 Vmn2r62 uc012fiz.1 uc012fiz.2 uc012fiz.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012fiz.1 uc012fiz.2 uc012fiz.3 
ENSMUST00000169143.8 Catsperg1 ENSMUST00000169143.8 cation channel sperm associated auxiliary subunit gamma 1, transcript variant 2 (from RefSeq NM_001368407.1) CTSG1_MOUSE E9PW02 E9Q355 E9QAY8 ENSMUST00000169143.1 ENSMUST00000169143.2 ENSMUST00000169143.3 ENSMUST00000169143.4 ENSMUST00000169143.5 ENSMUST00000169143.6 ENSMUST00000169143.7 NM_001368407 Q3V0A1 Q8C9D6 Q8CAA4 Q8R5F0 uc291npk.1 uc291npk.2 Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=E9Q355-1; Sequence=Displayed; Name=2; IsoId=E9Q355-2; Sequence=VSP_042991; Name=3; IsoId=E9Q355-3; Sequence=VSP_042983, VSP_042991, VSP_042994; Name=4; IsoId=E9Q355-4; Sequence=VSP_042986, VSP_042987, VSP_042989, VSP_042990; Name=5; IsoId=E9Q355-5; Sequence=VSP_042987, VSP_042988, VSP_042992, VSP_042993; Name=6; IsoId=E9Q355-6; Sequence=VSP_042984, VSP_042985, VSP_042989, VSP_042990; Belongs to the CATSPERG family. Despite its name, it is unclear whether the protein is part of some Catsper complex: in contrast to Catsperg2, it has not been identified in the Catsper complex and its expression is not restricted to testis tissues. molecular_function biological_process membrane integral component of membrane motile cilium CatSper complex sperm principal piece uc291npk.1 uc291npk.2 
ENSMUST00000169146.2 Gm17168 ENSMUST00000169146.2 Gm17168 (from geneSymbol) ENSMUST00000169146.1 uc289mei.1 uc289mei.2 uc289mei.1 uc289mei.2 
ENSMUST00000169154.2 Smr2l ENSMUST00000169154.2 submaxillary gland androgen regulated protein 2 like (from RefSeq NM_001110779.2) E9Q079 E9Q079_MOUSE ENSMUST00000169154.1 Gm7714 NM_001110779 Smr2l uc008xzo.1 uc008xzo.2 May play a role in protection or detoxification. Secreted endopeptidase inhibitor activity extracellular region negative regulation of endopeptidase activity regulation of sensory perception of pain uc008xzo.1 uc008xzo.2 
ENSMUST00000169156.3 Abhd12b ENSMUST00000169156.3 abhydrolase domain containing 12B (from RefSeq NM_001195033.2) Abhd12b ENSMUST00000169156.1 ENSMUST00000169156.2 G3UZN6 G3UZN6_MOUSE NM_001195033 uc011yni.1 uc011yni.2 uc011yni.3 molecular_function cellular_component biological_process uc011yni.1 uc011yni.2 uc011yni.3 
ENSMUST00000169159.3 Ms4a1 ENSMUST00000169159.3 membrane-spanning 4-domains, subfamily A, member 1 (from RefSeq NM_007641.6) ENSMUST00000169159.1 ENSMUST00000169159.2 Ms4a1 NM_007641 Q542S5 Q542S5_MOUSE uc008grw.1 uc008grw.2 uc008grw.3 Belongs to the MS4A family. store-operated calcium entry epidermal growth factor receptor binding nucleus plasma membrane integral component of plasma membrane cell surface membrane integral component of membrane immunoglobulin binding B cell differentiation B cell activation plasma membrane raft B cell receptor signaling pathway protein tetramerization calcium ion import into cytosol uc008grw.1 uc008grw.2 uc008grw.3 
ENSMUST00000169163.2 Gm17140 ENSMUST00000169163.2 Gm17140 (from geneSymbol) ENSMUST00000169163.1 uc288ylp.1 uc288ylp.2 uc288ylp.1 uc288ylp.2 
ENSMUST00000169165.2 Vmn1r128 ENSMUST00000169165.2 vomeronasal 1 receptor 128 (from RefSeq NM_001166739.1) ENSMUST00000169165.1 L7N2B4 L7N2B4_MOUSE NM_001166739 Vmn1r128 uc012fdc.1 uc012fdc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fdc.1 uc012fdc.2 
ENSMUST00000169168.3 Cysltr2 ENSMUST00000169168.3 cysteinyl leukotriene receptor 2, transcript variant 2 (from RefSeq NM_001162412.2) A2RT90 CLTR2_MOUSE Cyslt2 ENSMUST00000169168.1 ENSMUST00000169168.2 NM_001162412 Q920A1 uc011zoi.1 uc011zoi.2 uc011zoi.3 Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4. Cell membrane; Multi-pass membrane protein. Widely expressed at low levels, with highest expression in the spleen, thymus and adrenal gland, and lower in the kidney, brain and peripheral blood leukocytes. Belongs to the G-protein coupled receptor 1 family. cysteinyl leukotriene receptor activity G-protein coupled receptor activity galanin receptor activity leukotriene receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway G-protein coupled peptide receptor activity positive regulation of cell death membrane integral component of membrane positive regulation of angiogenesis leukotriene signaling pathway positive regulation of ERK1 and ERK2 cascade uc011zoi.1 uc011zoi.2 uc011zoi.3 
ENSMUST00000169169.8 Tnnc1 ENSMUST00000169169.8 troponin C, cardiac/slow skeletal (from RefSeq NM_009393.4) ENSMUST00000169169.1 ENSMUST00000169169.2 ENSMUST00000169169.3 ENSMUST00000169169.4 ENSMUST00000169169.5 ENSMUST00000169169.6 ENSMUST00000169169.7 NM_009393 P19123 TNNC1_MOUSE Tncc uc007sxd.1 uc007sxd.2 uc007sxd.3 Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium. Belongs to the troponin C family. diaphragm contraction skeletal muscle contraction calcium ion binding troponin complex regulation of muscle contraction response to metal ion transition between fast and slow fiber troponin I binding troponin T binding regulation of muscle filament sliding speed protein homodimerization activity contractile fiber regulation of ATPase activity metal ion binding calcium-dependent protein binding actin filament binding ventricular cardiac muscle tissue morphogenesis cardiac muscle contraction cardiac Troponin complex uc007sxd.1 uc007sxd.2 uc007sxd.3 
ENSMUST00000169172.5 Tbck ENSMUST00000169172.5 TBC1 domain containing kinase (from RefSeq NM_001163455.2) E9Q1W7 E9Q1W7_MOUSE ENSMUST00000169172.1 ENSMUST00000169172.2 ENSMUST00000169172.3 ENSMUST00000169172.4 NM_001163455 Tbck uc012cxw.1 uc012cxw.2 uc012cxw.3 protein kinase activity ATP binding cytoplasm protein phosphorylation cell proliferation actin cytoskeleton organization midbody regulation of TOR signaling mitotic spindle uc012cxw.1 uc012cxw.2 uc012cxw.3 
ENSMUST00000169175.2 Gm17116 ENSMUST00000169175.2 Gm17116 (from geneSymbol) AK041104 ENSMUST00000169175.1 uc057ksu.1 uc057ksu.2 uc057ksu.1 uc057ksu.2 
ENSMUST00000169189.8 H2-M5 ENSMUST00000169189.8 histocompatibility 2, M region locus 5, transcript variant 1 (from RefSeq NM_001115075.2) A7VMS3 A7VMS3_MOUSE ENSMUST00000169189.1 ENSMUST00000169189.2 ENSMUST00000169189.3 ENSMUST00000169189.4 ENSMUST00000169189.5 ENSMUST00000169189.6 ENSMUST00000169189.7 H2-M5 NM_001115075 uc008clt.1 uc008clt.2 Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc008clt.1 uc008clt.2 
ENSMUST00000169242.2 Gm17167 ENSMUST00000169242.2 Gm17167 (from geneSymbol) BC042474 ENSMUST00000169242.1 uc012dcn.1 uc012dcn.2 uc012dcn.3 uc012dcn.1 uc012dcn.2 uc012dcn.3 
ENSMUST00000169266.8 Cic ENSMUST00000169266.8 capicua transcriptional repressor, transcript variant 4 (from RefSeq NM_001302811.1) CIC_MOUSE ENSMUST00000169266.1 ENSMUST00000169266.2 ENSMUST00000169266.3 ENSMUST00000169266.4 ENSMUST00000169266.5 ENSMUST00000169266.6 ENSMUST00000169266.7 Kiaa0306 NM_001302811 Q3UH79 Q3UHP4 Q6PDJ8 Q8CGE4 Q8CHH0 Q924A2 Q9CW61 uc009fsa.1 uc009fsa.2 uc009fsa.3 uc009fsa.4 uc009fsa.5 Transcriptional repressor which plays a role in development of the central nervous system (CNS) (PubMed:17190598). In concert with ATXN1 and ATXN1L, involved in brain development (PubMed:28288114). Isoform 1: Interacts with ATXN1 (PubMed:17190598). Isoform 2: Interacts with ATXN1 (PubMed:17190598). Interacts with ATXN1L (PubMed:17322884). Found in a complex with ATXN1 and ATXN1L (PubMed:28288114). Q924A2; P54254: Atxn1; NbExp=2; IntAct=EBI-8412165, EBI-1169713; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=L; IsoId=Q924A2-4; Sequence=Displayed; Name=2; Synonyms=S; IsoId=Q924A2-2; Sequence=VSP_026140, VSP_026141, VSP_039804; Expressed in the cortex and hypothalamus (at protein level). Isoform 1: Present in cerebellum (at protein level) (PubMed:17190598). Isoform 2: Present in cerebellum (at protein level) (PubMed:17190598). Expressed postnatally in the hippocampus, neocortex, olfactory bulb and cerebellum. Expressed in the hippocampus from P0 to P15. Expressed in the posterior region of the neocortex at P4, the anterior region at P9, and is then lost by P15. Expressed in the cerebellum from P0, specifically within the external granule layer (EGL) which contains granule cell precursors. By P7 expression is distributed throughout the EGL and is reduced in the inner granule cell layer (IGL) where granule cells finally differentiate. Expression in the IGL continues to diminish up to P15, when granule cell neurogenesis is complete. Mice with conditional knockouts of either ATXN1- ATXN1L or CIC in the developing forebrain exhibit intellectual disability, hyperactivity, social-behavioral deficits and reduced thickness of upper cortical layers. Sequence=BAC41408.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; negative regulation of transcription from RNA polymerase II promoter DNA binding chromatin binding protein binding nucleus nucleoplasm brain development learning memory macromolecular complex social behavior intracellular membrane-bounded organelle negative regulation of transcription, DNA-templated lung alveolus development uc009fsa.1 uc009fsa.2 uc009fsa.3 uc009fsa.4 uc009fsa.5 
ENSMUST00000169282.8 Aph1c ENSMUST00000169282.8 aph1 homolog C, gamma secretase subunit, transcript variant 1 (from RefSeq NM_026674.4) APH1C_MOUSE ENSMUST00000169282.1 ENSMUST00000169282.2 ENSMUST00000169282.3 ENSMUST00000169282.4 ENSMUST00000169282.5 ENSMUST00000169282.6 ENSMUST00000169282.7 NM_026674 Q3U2R3 Q9DCZ9 uc009qfi.1 uc009qfi.2 uc009qfi.3 Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). Potential component of the gamma-secretase complex. Membrane ; Multi-pass membrane protein Belongs to the APH-1 family. metanephros development endopeptidase activity endoplasmic reticulum plasma membrane integral component of plasma membrane Notch signaling pathway Notch receptor processing peptidase activity membrane integral component of membrane protein processing positive regulation of catalytic activity gamma-secretase complex uc009qfi.1 uc009qfi.2 uc009qfi.3 
ENSMUST00000169295.8 Lax1 ENSMUST00000169295.8 lymphocyte transmembrane adaptor 1, transcript variant 2 (from RefSeq NM_172842.3) ENSMUST00000169295.1 ENSMUST00000169295.2 ENSMUST00000169295.3 ENSMUST00000169295.4 ENSMUST00000169295.5 ENSMUST00000169295.6 ENSMUST00000169295.7 LAX1_MOUSE Lax NM_172842 Q8BHB3 Q8BS18 Q8CGV1 uc007cqs.1 uc007cqs.2 uc007cqs.3 uc007cqs.4 Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. When phosphorylated, interacts with GRB2, PIK3R1 and GRAP2. Cell membrane ; Single-pass type III membrane protein Expressed in T-cells and B-cells. Up-regulated in T- and B-cells following TCR and BCR engagement, respectively. Phosphorylated on tyrosines upon TCR or BCR activation; which leads to the recruitment of GRB2, PIK3R1 and GRAP2. Mice are viable, fertile and healthy, and show normal lymphocyte development. However, their T- and B-cells are hyperresponsive to stimulation via TCR or BCR. inactivation of MAPK activity adaptive immune response immune system process Golgi apparatus cytosol plasma membrane immune response membrane integral component of membrane protein kinase binding intracellular signal transduction B cell activation SH2 domain binding lymphocyte activation immunoglobulin secretion antigen receptor-mediated signaling pathway negative regulation of T cell activation regulation of lymphocyte activation uc007cqs.1 uc007cqs.2 uc007cqs.3 uc007cqs.4 
ENSMUST00000169312.2 Derpc ENSMUST00000169312.2 DERPC proline and glycine rich nuclear protein, transcript variant 4 (from RefSeq NM_001378379.1) DERPC_MOUSE Derpc ENSMUST00000169312.1 NM_001378379 P0C6T0 P0CG14 Q8BHM2 Q8R5A5 uc009ngq.1 uc009ngq.2 uc009ngq.3 Potential tumor suppressor. Nucleus Belongs to the DERPC family. nucleus nucleoplasm uc009ngq.1 uc009ngq.2 uc009ngq.3 
ENSMUST00000169350.9 Sspo ENSMUST00000169350.9 SCO-spondin (from RefSeq NM_173428.4) E9Q0I4 E9Q0I4_MOUSE ENSMUST00000169350.1 ENSMUST00000169350.2 ENSMUST00000169350.3 ENSMUST00000169350.4 ENSMUST00000169350.5 ENSMUST00000169350.6 ENSMUST00000169350.7 ENSMUST00000169350.8 NM_173428 Sspo uc029vvf.1 uc029vvf.2 uc029vvf.3 Secreted, extracellular space Belongs to the thrombospondin family. Lacks conserved residue(s) required for the propagation of feature annotation. nervous system development cell differentiation uc029vvf.1 uc029vvf.2 uc029vvf.3 
ENSMUST00000169357.2 Fancf ENSMUST00000169357.2 Fanconi anemia, complementation group F (from RefSeq NM_001115087.1) E9Q5Z5 ENSMUST00000169357.1 FANCF_MOUSE Fancf NM_001115087 uc012flg.1 uc012flg.2 uc012flg.3 DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. In complex with FANCA, FANCG and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins. Nucleus Viable with no gross developmental abnormalities or significant growth retardation. Gonad defects are present in both male and female mice. Testes are devoid of germ cells. Ovaries show premature depletion of primordial follicles with almost complete loss by 14 weeks of age, and aberrant estrous cycle. Significantly increased incidence of tumors, particularly ovarian tumors. ovarian follicle development nucleus DNA repair cellular response to DNA damage stimulus spermatogenesis protein ubiquitination interstrand cross-link repair Fanconi anaemia nuclear complex ubiquitin protein ligase activity uc012flg.1 uc012flg.2 uc012flg.3 
ENSMUST00000169361.2 Gm3486 ENSMUST00000169361.2 Gm3486 (from geneSymbol) ENSMUST00000169361.1 Gm3486 L7N2D0 L7N2D0_MOUSE uc288snv.1 uc288snv.2 molecular_function cellular_component biological_process uc288snv.1 uc288snv.2 
ENSMUST00000169362.2 Gm3542 ENSMUST00000169362.2 Gm3542 (from geneSymbol) ENSMUST00000169362.1 Gm3542 Gm9603 K7N6U2 K7N6U2_MOUSE uc288qlx.1 uc288qlx.2 membrane integral component of membrane uc288qlx.1 uc288qlx.2 
ENSMUST00000169374.2 Vmn1r115 ENSMUST00000169374.2 vomeronasal 1 receptor 115 (from RefSeq NM_001166745.1) ENSMUST00000169374.1 K7N6Y3 K7N6Y3_MOUSE NM_001166745 Vmn1r115 uc012fcp.1 uc012fcp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fcp.1 uc012fcp.2 
ENSMUST00000169382.3 Rbmyf7 ENSMUST00000169382.3 RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. (from UniProt O35698) AK016258 E9Q856 ENSMUST00000169382.1 ENSMUST00000169382.2 O35698 RBY1A_MOUSE Rbm Rbmy1a1 uc292ryb.1 uc292ryb.2 RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. Nucleus Testis-specific. Only expressed in spermatogonia and early spermatocytes, suggesting that expression is inactivated in the XY body during meiosis. The RBMY1 proteins are encoded by repeated regions of the Y chromosome. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. Overexpression of Rbmy proteins in mice carrying the Y(d1) deletion that removes most of the multi-copy Rbmy gene cluster does not have any effect and fails to reduce the frequency of abnormal sperm. These results raize the question of the role of Rbmy proteins in sperm development. male germ cell nucleus hematopoietic progenitor cell differentiation nucleic acid binding RNA binding nucleus spliceosomal complex mRNA processing RNA splicing positive regulation of mRNA splicing, via spliceosome ribonucleoprotein complex uc292ryb.1 uc292ryb.2 
ENSMUST00000169385.3 Rai14 ENSMUST00000169385.3 retinoic acid induced 14, transcript variant 2 (from RefSeq NM_001166408.2) ENSMUST00000169385.1 ENSMUST00000169385.2 Kiaa1334 NM_001166408 Norpeg Q3URT3 Q6ZPT6 Q9EP71 RAI14_MOUSE uc007vgn.1 uc007vgn.2 uc007vgn.3 uc007vgn.4 Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood- testis barrier. Interacts with PALLD (By similarity). Associates with actin (PubMed:11168586). However, does not bind F-actin directly (PubMed:11168586). Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, stress fiber Cytoplasm, cell cortex Cell junction Nucleus Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites (PubMed:11168586). Highly expressed at the ectoplasmic specialization, an actin-rich cell junction specific to the testis (By similarity). Predominantly nuclear in nonconfluent cells (By similarity). Highly expressed in testis, where it localizes to seminiferous tubules (at protein level) (PubMed:11042181, PubMed:16806700). Expressed in ganglion cell layer and in Muller cell fibers of the retina (at protein level) (PubMed:11042181, PubMed:16806700). In small intestine highly expressed at the apical and lateral borders of absorptive epithelia (at protein level) (PubMed:11168586). In liver highly expressed along the bile canaliculi (at protein level) (PubMed:11168586). At 9.5 days, expression is detected in branchial arch mesenchyme, forebrain, hindbrain, midbrain, and neural tube. At 12.5 days, is detected in the hindbrain, forebrain, lung, genital eminence, spinal ligaments around vertebrae and ribs, and around the cartilage of ribs and nasal sinuses. Also detected in frontonasal mass, mandibular arch, optic sulcus, spinal ganglia and hind limb bud. At 15.5 days, expression is detected in the ventricular layer of neurons subjacent to the neocortex, around the nasal sinuses, bronchioles of the lung, kidney, and around the vertebrae of the tail. Also seen in the olfactory bulb. Sequence=BAC98143.1; Type=Erroneous initiation; Evidence=; fibrillar center actin binding nucleus cytoplasm mitochondrion cytosol cytoskeleton cell cortex spermatogenesis cell junction cell differentiation uc007vgn.1 uc007vgn.2 uc007vgn.3 uc007vgn.4 
ENSMUST00000169390.8 Enoph1 ENSMUST00000169390.8 enolase-phosphatase 1, transcript variant 3 (from RefSeq NR_027990.1) ENOPH_MOUSE ENSMUST00000169390.1 ENSMUST00000169390.2 ENSMUST00000169390.3 ENSMUST00000169390.4 ENSMUST00000169390.5 ENSMUST00000169390.6 ENSMUST00000169390.7 Masa NR_027990 Q3TGK8 Q3TXA2 Q3U8Y4 Q8BGB7 Q8VC92 Q9D6U4 uc008yhb.1 uc008yhb.2 uc008yhb.3 uc008yhb.4 Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Reaction=5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2- dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate; Xref=Rhea:RHEA:21700, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:49252, ChEBI:CHEBI:58828; EC=3.1.3.77; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6. Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. Monomer. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGB7-1; Sequence=Displayed; Name=2; IsoId=Q8BGB7-2; Sequence=VSP_021161; Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. Sequence=BAE30883.1; Type=Frameshift; Evidence=; magnesium ion binding nucleus cytoplasm cellular amino acid biosynthetic process methionine biosynthetic process dephosphorylation hydrolase activity L-methionine biosynthetic process from S-adenosylmethionine L-methionine biosynthetic process from methylthioadenosine 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity acireductone synthase activity metal ion binding uc008yhb.1 uc008yhb.2 uc008yhb.3 uc008yhb.4 
ENSMUST00000169398.3 Ubtfl1 ENSMUST00000169398.3 Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development. (from UniProt Q3USZ2) AK139937 ENSMUST00000169398.1 ENSMUST00000169398.2 Hmgpi Q3TQX0 Q3USZ2 UBFL1_MOUSE Ubtfl1 uc033jix.1 uc033jix.2 uc033jix.3 Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development. Cytoplasm Nucleus Note=Mainly cytoplasmic from the 4-cell stage to the morula stage. Becomes nuclear at the blastocyst stage. In ES cells, found in both the nucleus and the cytoplasm. Transcriptionally activated at the 2-cell stage, peaks at the 4-cell stage and then gradually decreased until the blastocyst stage. The protein is detected from the 4-cell stage until the blastocyst stage. In blastocysts, expressed both by inner cell mass and trophectodermal cells (at protein level). Not detected in post- implentation, neither in fetal, nor adult tissues. blastocyst growth molecular_function DNA binding nucleus cytoplasm multicellular organism development embryo implantation regulation of gene expression uc033jix.1 uc033jix.2 uc033jix.3 
ENSMUST00000169415.3 Dynlt1a ENSMUST00000169415.3 dynein light chain Tctex-type 1A (from RefSeq NM_001166629.2) DYLT1_MOUSE Dynlt1 ENSMUST00000169415.1 ENSMUST00000169415.2 NM_001166629 P51807 Q5M8S6 Tctel1 Tctex-1 Tctex1 uc008agl.1 uc008agl.2 uc008agl.3 uc008agl.4 uc008agl.5 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia (By similarity). May also be a accessory component of axonemal dynein. Plays an important role in male germ cell development and function. Candidate for involvement in male sterility. Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta- gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling. Involved in the regulation of mitotic spindle orientation. Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non- catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with RHO (By similarity). Interacts with DYNC1I1 and DYNC1I2. Interacts with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2. Interacts with GNB1; the interaction occurs in presence of guanine nucleotide- binding protein G(T) subunit gamma; the interaction diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the interactions occur in presence of guanine nucleotide-binding protein G(T) subunit gamma. Interacts with ACVR2B and ARHGEF2 (By similarity). Interacts with DNAI4 (PubMed:30060180). P51807; P39688: Fyn; NbExp=3; IntAct=EBI-642797, EBI-524514; P51807; O46385: SVIL; Xeno; NbExp=4; IntAct=EBI-642797, EBI-6995105; Golgi apparatus Cytoplasm Cytoplasm, cytoskeleton, spindle Note=Localizes to mitotic spindles. High level in testis (germ cell-specific). Expressed in sperm (at protein level). 200-fold lower in liver, brain, heart, spleen, and kidney. Levels in thymus and two embryonal carcinoma cell lines were several-fold higher than this low constitutive level. First abundantly expressed at the pachytene stage of meiosis and persists throughout spermatogenesis. Phosphorylated by BMPR2. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release (By similarity). Belongs to the dynein light chain Tctex-type family. establishment of mitotic spindle orientation photoreceptor inner segment motor activity protein binding cytoplasm Golgi apparatus spindle cytoskeleton cytoplasmic dynein complex microtubule cytoplasmic microtubule cell cycle nervous system development protein C-terminus binding regulation of G-protein coupled receptor protein signaling pathway positive regulation of neuron projection development lamellipodium dynein complex growth cone GTP-dependent protein binding G-protein beta-subunit binding identical protein binding neuronal cell body axonal growth cone cell body negative regulation of neurogenesis cell division negative regulation of ERK1 and ERK2 cascade secretory vesicle uc008agl.1 uc008agl.2 uc008agl.3 uc008agl.4 uc008agl.5 
ENSMUST00000169433.3 C2cd4d ENSMUST00000169433.3 C2 calcium-dependent domain containing 4D (from RefSeq NM_001136117.2) C2C4D_MOUSE ENSMUST00000169433.1 ENSMUST00000169433.2 Gm659 NM_001136117 P0CG09 uc012ctl.1 uc012ctl.2 uc012ctl.3 biological_process uc012ctl.1 uc012ctl.2 uc012ctl.3 
ENSMUST00000169439.3 Myocos ENSMUST00000169439.3 myocilin opposite strand (from RefSeq NM_001177581.1) ENSMUST00000169439.1 ENSMUST00000169439.2 MYCOS_MOUSE Myocos NM_001177581 Q3UWS6 uc007dgn.1 uc007dgn.2 uc007dgn.3 uc007dgn.4 molecular_function cellular_component biological_process uc007dgn.1 uc007dgn.2 uc007dgn.3 uc007dgn.4 
ENSMUST00000169449.8 Slc6a17 ENSMUST00000169449.8 solute carrier family 6 (neurotransmitter transporter), member 17, transcript variant 1 (from RefSeq NM_001293689.1) B2RUH5 ENSMUST00000169449.1 ENSMUST00000169449.2 ENSMUST00000169449.3 ENSMUST00000169449.4 ENSMUST00000169449.5 ENSMUST00000169449.6 ENSMUST00000169449.7 NM_001293689 Ntt4 Q8BJI1 Q8C057 Q8CGQ9 S6A17_MOUSE Slc6a17 uc008qxc.1 uc008qxc.2 uc008qxc.3 Synaptic vesicle transporter with apparent selectivity for neutral amino acids. The transport is sodium-coupled but chloride- independent, likely driven by the proton electrochemical gradient generated by vacuolar H(+)-ATPase in an overall electrogenic mechanism. May contribute to the synaptic uptake of neurotransmitter precursors in a process coupled in part to vesicle exocytosis. Reaction=L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out); Xref=Rhea:RHEA:28967, ChEBI:CHEBI:29101, ChEBI:CHEBI:60039; Evidence=; Reaction=L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out); Xref=Rhea:RHEA:29263, ChEBI:CHEBI:29101, ChEBI:CHEBI:57427; Evidence=; Reaction=glycine(in) + Na(+)(in) = glycine(out) + Na(+)(out); Xref=Rhea:RHEA:68228, ChEBI:CHEBI:29101, ChEBI:CHEBI:57305; Evidence=; Reaction=L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out); Xref=Rhea:RHEA:29283, ChEBI:CHEBI:29101, ChEBI:CHEBI:57972; Evidence=; Reaction=L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out); Xref=Rhea:RHEA:68236, ChEBI:CHEBI:29101, ChEBI:CHEBI:58359; Evidence=; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Postsynapse Presynapse Note=Localizes at synaptic junctions - at both pre- and post-synaptic sites - particularly in excitatory glutamatergic terminals. Expressed in the brain. The strongest expression levels in embryonic, postnatal, and adult stages are found in both cortical and hippocampal tissues. Expressed during embryonic brain development and the highest levels are observed postnatally. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. neurotransmitter:sodium symporter activity integral component of plasma membrane neurotransmitter transport brain development synaptic vesicle symporter activity neutral amino acid transport glycine transport leucine transport proline transport membrane integral component of membrane cell junction integral component of synaptic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle alanine transport synapse transmembrane transport glutamatergic synapse GABA-ergic synapse uc008qxc.1 uc008qxc.2 uc008qxc.3 
ENSMUST00000169459.4 Pdzd7 ENSMUST00000169459.4 PDZ domain containing 7 (from RefSeq NM_001195265.1) E9Q9U9 E9Q9W7 ENSMUST00000169459.1 ENSMUST00000169459.2 ENSMUST00000169459.3 NM_001195265 PDZD7_MOUSE Pdzd7 X4YT42 X4YT46 X4YZM3 X4ZGA7 uc012bmk.1 uc012bmk.2 uc012bmk.3 In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links (PubMed:24334608). Blocks inhibition of adenylate cyclase activity mediated by ADGRV1 (PubMed:24962568). Homodimerizes (via PDZ2 domain) (PubMed:25406310). Component of USH2 complex, composed of ADGRV1, PDZD7, USH2A and WHRN (PubMed:25406310). Interacts (via PDZ domains) with WHRN; the interaction is direct (PubMed:25406310). Interacts with USH1G (By similarity). Interacts with ADGRV1 (via the cytoplasmic region) (PubMed:24962568, PubMed:23055499). Interacts with USH2A (via the cytoplasmic region) (PubMed:23055499). Interacts with MYO7A (via MyTH4- FERM domains) (PubMed:27525485). Cell projection, cilium Nucleus Cell projection, stereocilium te=Localizes at the ankle region of the stereocilia. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=E9Q9W7-1; Sequence=Displayed; Name=2 ; IsoId=E9Q9W7-2; Sequence=VSP_059957, VSP_059958; Name=3 ; IsoId=E9Q9W7-3; Sequence=VSP_059955, VSP_059956; Name=4 ; IsoId=E9Q9W7-4; Sequence=VSP_059952; Name=5 ; IsoId=E9Q9W7-5; Sequence=VSP_059953, VSP_059954; Isoform 1 is expressed in developing and adult cochlea but not retina (PubMed:24334608). Isoform 2 is expressed in developing and adult cochlea and retina (PubMed:24334608). Isoform 3 is expressed in adult cochlea and retina (PubMed:24334608). Isoform 4 is expressed in retina and developing cochlea but not adult cochlea (PubMed:24334608). Isoform 5 is expressed in adult cochlea but not in developing cochlea or retina (PubMed:24334608). In cochlea hair cells, only isoforms 1, 2 and 4 are expressed at P5. At P24, isoforms 1, 2, 3 and 5 are expressed. Mutant mice exhibit congenital profound deafness and normal vestibular function. They show disorganized stereocilia bundles with a reduction in mechanotransduction currents and sensitivity in cochlear outer cells (PubMed:24334608). Knockout mice have normal vision function from rod and cone photoreceptors (PubMed:24334608). [Isoform 1]: Expressed in developing and adult cochlea but not retina. [Isoform 2]: Expressed in developing and adult cochlea and retina. [Isoform 3]: Expressed in adult cochlea and retina. [Isoform 4]: Expressed in retina and developing cochlea but not adult cochlea. [Isoform 5]: Expressed in adult cochlea but not in developing cochlea or retina. stereocilia ankle link stereocilia ankle link complex protein binding nucleus plasma membrane cilium sensory perception of sound stereocilium stereocilium tip protein homodimerization activity cell projection establishment of protein localization protein heterodimerization activity detection of mechanical stimulus involved in sensory perception of sound auditory receptor cell stereocilium organization auditory receptor cell development USH2 complex photoreceptor inner segment photoreceptor connecting cilium uc012bmk.1 uc012bmk.2 uc012bmk.3 
ENSMUST00000169485.6 Dhx37 ENSMUST00000169485.6 DEAH-box helicase 37, transcript variant 2 (from RefSeq NR_184665.1) Dhx37 ENSMUST00000169485.1 ENSMUST00000169485.2 ENSMUST00000169485.3 ENSMUST00000169485.4 ENSMUST00000169485.5 NR_184665 Q6NZL1 Q6NZL1_MOUSE uc008zrq.1 uc008zrq.2 uc008zrq.3 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Belongs to the DEAD box helicase family. DEAH subfamily. nucleotide binding maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleic acid binding RNA binding helicase activity ATP binding nucleus nucleolus hydrolase activity uc008zrq.1 uc008zrq.2 uc008zrq.3 
ENSMUST00000169499.2 Gm14569 ENSMUST00000169499.2 predicted gene 14569 (from RefSeq NM_001370943.1) E9Q0C6 ENSMUST00000169499.1 Gm14569 K1210_MOUSE Kiaa1210 NM_001370943 uc292nsa.1 uc292nsa.2 Interacts with TOP2B. Cytoplasmic vesicle, secretory vesicle, acrosome Note=Localizes to the sex body in spermatocyte, acrosome, and near the ectoplasmic specialization. Predominantly expressed in testis (at protein level). acrosomal vesicle cytoplasmic vesicle uc292nsa.1 uc292nsa.2 
ENSMUST00000169503.4 Strn3 ENSMUST00000169503.4 striatin, calmodulin binding protein 3, transcript variant 2 (from RefSeq NM_001172098.1) B2RQS1 B2RQS1_MOUSE ENSMUST00000169503.1 ENSMUST00000169503.2 ENSMUST00000169503.3 NM_001172098 Strn3 uc007nmu.1 uc007nmu.2 uc007nmu.3 uc007nmu.4 Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. Belongs to the WD repeat striatin family. uc007nmu.1 uc007nmu.2 uc007nmu.3 uc007nmu.4 
ENSMUST00000169534.6 Txk ENSMUST00000169534.6 TXK tyrosine kinase, transcript variant 2 (from RefSeq NM_013698.3) B2RQ20 B2RQ20_MOUSE ENSMUST00000169534.1 ENSMUST00000169534.2 ENSMUST00000169534.3 ENSMUST00000169534.4 ENSMUST00000169534.5 NM_013698 Txk uc008xrw.1 uc008xrw.2 uc008xrw.3 uc008xrw.4 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Belongs to the protein kinase superfamily. Tyr protein kinase family. nucleotide binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II regulatory region DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity ATP binding nucleus cytoplasm regulation of transcription from RNA polymerase II promoter protein phosphorylation kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation positive regulation of interferon-gamma production positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation positive regulation of interferon-gamma-mediated signaling pathway uc008xrw.1 uc008xrw.2 uc008xrw.3 uc008xrw.4 
ENSMUST00000169544.8 Sult6b1 ENSMUST00000169544.8 sulfotransferase family, cytosolic, 6B, member 1 (from RefSeq NM_001163625.2) ENSMUST00000169544.1 ENSMUST00000169544.2 ENSMUST00000169544.3 ENSMUST00000169544.4 ENSMUST00000169544.5 ENSMUST00000169544.6 ENSMUST00000169544.7 NM_001163625 P0CC03 ST6B1_MOUSE uc012axk.1 uc012axk.2 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine. Reaction=3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'- bisphosphate + H(+) + thyroxine sulfate; Xref=Rhea:RHEA:26422, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58910, ChEBI:CHEBI:305790; EC=2.8.2.n2; Evidence=; Kinetic parameters: KM=143.7 uM for thyroxine ; Vmax=40.4 pmol/min/mg enzyme ; pH dependence: Optimum pH is 8. ; Cytoplasm, cytosol Expressed in brain, heart, kidney, thymus, lung, liver and testis. Belongs to the sulfotransferase 1 family. molecular_function cellular_component cytoplasm sulfotransferase activity biological_process transferase activity uc012axk.1 uc012axk.2 
ENSMUST00000169556.3 Vmn1r56 ENSMUST00000169556.3 vomeronasal 1 receptor 56 (from RefSeq NM_030740.1) ENSMUST00000169556.1 ENSMUST00000169556.2 NM_030740 Q9EPS9 Q9EPS9_MOUSE V1rd3 Vmn1r56 uc009fad.1 uc009fad.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009fad.1 uc009fad.2 
ENSMUST00000169559.3 Vmn2r110 ENSMUST00000169559.3 vomeronasal 2, receptor 110 (from RefSeq NM_001104572.1) E9PWD5 E9PWD5_MOUSE ENSMUST00000169559.1 ENSMUST00000169559.2 NM_001104572 Vmn2r110 uc009vbn.1 uc009vbn.2 uc009vbn.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vbn.1 uc009vbn.2 uc009vbn.3 
ENSMUST00000169587.2 Gm8126 ENSMUST00000169587.2 predicted gene 8126, transcript variant 3 (from RefSeq NM_001374185.1) E9Q1N7 E9Q1N7_MOUSE ENSMUST00000169587.1 Gm8126 NM_001374185 uc288srl.1 uc288srl.2 uc288srl.1 uc288srl.2 
ENSMUST00000169591.8 Cyp4f16 ENSMUST00000169591.8 cytochrome P450, family 4, subfamily f, polypeptide 16, transcript variant 1 (from RefSeq NM_024442.2) Cyp4f16 ENSMUST00000169591.1 ENSMUST00000169591.2 ENSMUST00000169591.3 ENSMUST00000169591.4 ENSMUST00000169591.5 ENSMUST00000169591.6 ENSMUST00000169591.7 NM_024442 Q99N17 Q99N17_MOUSE uc008bxg.1 uc008bxg.2 uc008bxg.3 Belongs to the cytochrome P450 family. molecular_function monooxygenase activity iron ion binding cellular_component oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc008bxg.1 uc008bxg.2 uc008bxg.3 
ENSMUST00000169593.2 Zbtb42 ENSMUST00000169593.2 zinc finger and BTB domain containing 42 (from RefSeq NM_001100460.1) ENSMUST00000169593.1 NM_001100460 Q811H0 ZBT42_MOUSE uc007pfa.1 uc007pfa.2 uc007pfa.3 Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Cytoplasm Nucleus, nucleoplasm Note=In skeletal myofibers, highly enriched in subsynaptic nuclei at the neuromuscular junctions. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q811H0-1; Sequence=Displayed; Name=2; IsoId=Q811H0-2; Sequence=VSP_038770; Highly expressed in skeletal muscle and ovary (at protein level). Low expression in brain, lung, spleen, liver and heart (at protein level). Not detected in kidney and intestines (at protein level). Also observed in testis and, at lower levels, in stomach and nervous system. Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily. Sequence=AAH46387.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleic acid binding DNA binding nucleus nucleoplasm cytoplasm plasma membrane cellular response to DNA damage stimulus muscle organ development metal ion binding uc007pfa.1 uc007pfa.2 uc007pfa.3 
ENSMUST00000169604.8 1700088E04Rik ENSMUST00000169604.8 RIKEN cDNA 1700088E04 gene, transcript variant 1 (from RefSeq NM_138581.2) ENSMUST00000169604.1 ENSMUST00000169604.2 ENSMUST00000169604.3 ENSMUST00000169604.4 ENSMUST00000169604.5 ENSMUST00000169604.6 ENSMUST00000169604.7 EVG1_MOUSE NM_138581 Q9D9S1 uc007wss.1 uc007wss.2 uc007wss.3 Belongs to the UPF0193 (EVG1) family. molecular_function cellular_component biological_process uc007wss.1 uc007wss.2 uc007wss.3 
ENSMUST00000169611.4 Mmut ENSMUST00000169611.4 methylmalonyl-Coenzyme A mutase (from RefSeq NM_008650.3) ENSMUST00000169611.1 ENSMUST00000169611.2 ENSMUST00000169611.3 MUTA_MOUSE Mut NM_008650 P16332 Q3UJU1 uc008coo.1 uc008coo.2 uc008coo.3 uc008coo.4 Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. Reaction=(R)-methylmalonyl-CoA = succinyl-CoA; Xref=Rhea:RHEA:22888, ChEBI:CHEBI:57292, ChEBI:CHEBI:57326; EC=5.4.99.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22889; Evidence=; Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408; Evidence=; Inhibited by itaconyl-CoA, a metabolite that inactivates the coenzyme B12 cofactor. Kinetic parameters: KM=0.20 uM for adenosylcob(III)alamin ; KM=0.27 mM for methylmalonyl-CoA ; Homodimer. Interacts (the apoenzyme form) with MMAA; the interaction is GTP dependent. Mitochondrion matrix Mitochondrion Cytoplasm Belongs to the methylmalonyl-CoA mutase family. catalytic activity GTPase activity methylmalonyl-CoA mutase activity mitochondrion mitochondrial matrix post-embryonic development isomerase activity intramolecular transferase activity cobalamin binding identical protein binding protein homodimerization activity positive regulation of GTPase activity metal ion binding homocysteine metabolic process modified amino acid binding uc008coo.1 uc008coo.2 uc008coo.3 uc008coo.4 
ENSMUST00000169612.3 Inafm1 ENSMUST00000169612.3 InaF motif containing 1 (from RefSeq NM_001136270.1) E9PV59 E9PV59_MOUSE ENSMUST00000169612.1 ENSMUST00000169612.2 Inafm1 NM_001136270 uc012fag.1 uc012fag.2 uc012fag.3 calcium channel regulator activity cellular_component biological_process membrane integral component of membrane uc012fag.1 uc012fag.2 uc012fag.3 
ENSMUST00000169613.4 Gstp1 ENSMUST00000169613.4 glutathione S-transferase, pi 1 (from RefSeq NM_013541.1) ENSMUST00000169613.1 ENSMUST00000169613.2 ENSMUST00000169613.3 GSTP1_MOUSE Gstp1 Gstpib NM_013541 P19157 Q8BNY4 uc008fyf.1 uc008fyf.2 uc008fyf.3 uc008fyf.4 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16438; Evidence=; Reaction=glutathione + prostaglandin J2 = prostaglandin J2-S-(R)- glutathione; Xref=Rhea:RHEA:50804, ChEBI:CHEBI:57925, ChEBI:CHEBI:133396, ChEBI:CHEBI:133771; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50805; Evidence=; Reaction=glutathione + prostaglandin J2 = prostaglandin J2-S-(S)- glutathione; Xref=Rhea:RHEA:50808, ChEBI:CHEBI:57925, ChEBI:CHEBI:133396, ChEBI:CHEBI:133772; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50809; Evidence=; Reaction=glutathione + prostaglandin A2 = prostaglandin A2-S-(S)- glutathione; Xref=Rhea:RHEA:50800, ChEBI:CHEBI:57925, ChEBI:CHEBI:133370, ChEBI:CHEBI:133769; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50801; Evidence=; Reaction=11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)- eicosatrienoate; Xref=Rhea:RHEA:50260, ChEBI:CHEBI:57925, ChEBI:CHEBI:132200, ChEBI:CHEBI:132201; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50261; Evidence=; Homodimer. Interacts with CDK5 (By similarity). Cytoplasm Mitochondrion Nucleus Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization. Ubiquitously expressed. Mass=23478.8; Mass_error=2; Method=Electrospray; Evidence=; Belongs to the GST superfamily. Pi family. response to reactive oxygen species negative regulation of acute inflammatory response glutathione transferase activity glutathione peroxidase activity protein binding nucleus cytoplasm mitochondrion cytosol plasma membrane glutathione metabolic process xenobiotic metabolic process drug binding JUN kinase binding response to toxic substance oligodendrocyte development transferase activity kinase regulator activity protein kinase binding animal organ regeneration response to nutrient levels response to estradiol negative regulation of interleukin-1 beta production negative regulation of tumor necrosis factor production cellular response to insulin stimulus regulation of stress-activated MAPK cascade negative regulation of stress-activated MAPK cascade positive regulation of superoxide anion generation macromolecular complex response to L-ascorbic acid common myeloid progenitor cell proliferation S-nitrosoglutathione binding dinitrosyl-iron complex binding negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling response to amino acid glutathione binding negative regulation of MAP kinase activity negative regulation of JUN kinase activity response to ethanol negative regulation of fibroblast proliferation negative regulation of nitric-oxide synthase biosynthetic process regulation of ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade negative regulation of leukocyte proliferation cellular response to lipopolysaccharide cellular response to epidermal growth factor stimulus cellular response to glucocorticoid stimulus cellular response to cell-matrix adhesion negative regulation of monocyte chemotactic protein-1 production TRAF2-GSTP1 complex cellular oxidant detoxification negative regulation of neutrophil aggregation negative regulation of peroxidase activity negative regulation of extrinsic apoptotic signaling pathway uc008fyf.1 uc008fyf.2 uc008fyf.3 uc008fyf.4 
ENSMUST00000169622.8 Lrrc47 ENSMUST00000169622.8 Lrrc47 (from geneSymbol) AK154897 E9PV22 E9PV22_MOUSE ENSMUST00000169622.1 ENSMUST00000169622.2 ENSMUST00000169622.3 ENSMUST00000169622.4 ENSMUST00000169622.5 ENSMUST00000169622.6 ENSMUST00000169622.7 Lrrc47 uc290sgn.1 uc290sgn.2 RNA binding phenylalanine-tRNA ligase activity uc290sgn.1 uc290sgn.2 
ENSMUST00000169623.8 Arhgef16 ENSMUST00000169623.8 Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 (By similarity). (from UniProt Q3U5C8) ARHGG_MOUSE B1ASH6 BC137847 ENSMUST00000169623.1 ENSMUST00000169623.2 ENSMUST00000169623.3 ENSMUST00000169623.4 ENSMUST00000169623.5 ENSMUST00000169623.6 ENSMUST00000169623.7 Q3U5C8 Q501M8 Q8VCE8 uc012dqj.1 uc012dqj.2 uc012dqj.3 Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 (By similarity). Interacts with ELMO2, EPHA2, RAC1 and RHOG; mediates activation of RAC1 by EPHA2. Interacts with TAX1BP3 (via PDZ domain) (By similarity). Cytoplasm The PDZ-binding motif mediates interaction with TAX1BP3. Sequence=BAE32151.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cytoplasm Rho GTPase binding PDZ domain binding receptor tyrosine kinase binding regulation of Rho protein signal transduction cell chemotaxis activation of GTPase activity positive regulation of protein localization to plasma membrane uc012dqj.1 uc012dqj.2 uc012dqj.3 
ENSMUST00000169627.9 Tns2 ENSMUST00000169627.9 tensin 2, transcript variant 1 (from RefSeq NM_153533.4) ENSMUST00000169627.1 ENSMUST00000169627.2 ENSMUST00000169627.3 ENSMUST00000169627.4 ENSMUST00000169627.5 ENSMUST00000169627.6 ENSMUST00000169627.7 ENSMUST00000169627.8 NM_153533 Q3TZ93 Q3UGR8 Q8CGB6 Q8CJ95 Q8R122 TENS2_MOUSE Tenc1 uc007xuo.1 uc007xuo.2 uc007xuo.3 Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (By similarity). Phosphatase activity is mediated by binding to phosphatidylinositol- 3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (By similarity). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy. Negatively regulates PI3K-AKT pathway activation (By similarity). Dephosphorylates nephrin NPHS1 in podocytes which affects mTORC1 complex activity (By similarity). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (By similarity). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (PubMed:27246398, PubMed:31723089, PubMed:32390516). Enhances RHOA activation in the presence of DLC1 (By similarity). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Interacts with AXL. Interacts with SYK; leading to its phosphorylation. Interacts with SQSTM1 (via PB1 domain); the interaction leads to sequestration of TNS2 in cytoplasmic aggregates with SQSTM1 and promotes TNS2 ubiquitination and proteasomal degradation. Cell junction, focal adhesion Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm Note=Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies. Localizes to both focal adhesions and fibrillar adhesions but is found mainly in focal adhesions. Enriched in dynamic focal adhesions at the leading edge of the cell and is found only rarely in fibrillar adhesions on the ventral surface of cells. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8CGB6-1; Sequence=Displayed; Name=2; IsoId=Q8CGB6-2; Sequence=VSP_026462; Name=3; IsoId=Q8CGB6-3; Sequence=VSP_026464; Name=4; IsoId=Q8CGB6-4; Sequence=VSP_026463; In the adult kidney, expressed mainly in glomeruli (at protein level) (PubMed:28955049). In the newborn kidney, localizes on the basal surface of podocytes along the glomerular basement membrane and not in endothelial cells (PubMed:32390516). Low expression levels in anabolic skeletal muscles (PubMed:23401856). In the newborn kidney, weak expression is first observed in podocytes in the late S-shaped body or early capillary loop stage, increases with glomerular maturation and persists at a high level in mature glomeruli (at protein level) (PubMed:32390516). Expressed in skeletal muscle at 17.5 dpc until post natal day P0 and then decreases at P21 (PubMed:23401856). Induced under catabolic conditions in skeletal muscles. The SH3 domain mediates binding to phosphatidylinositol-3,4,5- triphosphate (PtdIns(3,4,5)P3) (By similarity). It is also required to ensure podocyte integrity while the phosphatase domain is dispensible for podocyte maintenance (PubMed:27246398, PubMed:31723089, PubMed:32390516). Ubiquitinated following sequestration in cytoplasmic aggregates with SQSTM1, leading to proteasomal degradation. Glomerular defects during postnatal nephrogenesis including severe glomerular basement membrane (GBM) thickening, effacement of podocyte foot processes, and mesangial expansion and sclerosis (PubMed:32390516). Ectopic expression of laminin LAMA2 in the GBM followed by the accumulation of immature laminin components (PubMed:32390516). Decreased adhesion of podocytes to the GBM (PubMed:32390516). Belongs to the PTEN phosphatase protein family. Sequence=BAE34316.1; Type=Frameshift; Evidence=; kidney development phosphoprotein phosphatase activity receptor binding plasma membrane focal adhesion protein dephosphorylation negative regulation of cell proliferation response to muscle activity membrane hydrolase activity cellular homeostasis kinase binding protein kinase binding cell junction collagen metabolic process multicellular organism growth intracellular signal transduction metal ion binding multicellular organismal homeostasis uc007xuo.1 uc007xuo.2 uc007xuo.3 
ENSMUST00000169630.8 Mrgbp ENSMUST00000169630.8 MRG/MORF4L binding protein, transcript variant 3 (from RefSeq NR_151481.1) ENSMUST00000169630.1 ENSMUST00000169630.2 ENSMUST00000169630.3 ENSMUST00000169630.4 ENSMUST00000169630.5 ENSMUST00000169630.6 ENSMUST00000169630.7 MRGBP_MOUSE NR_151481 Q14AR7 Q9DAT2 uc008ojh.1 uc008ojh.2 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DAT2-1; Sequence=Displayed; Name=2; IsoId=Q9DAT2-2; Sequence=VSP_003793; Belongs to the EAF7 family. Sequence=BAB24117.1; Type=Frameshift; Evidence=; molecular_function nucleus chromatin organization regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter histone acetylation NuA4 histone acetyltransferase complex regulation of growth H4/H2A histone acetyltransferase complex uc008ojh.1 uc008ojh.2 
ENSMUST00000169631.8 Skint5 ENSMUST00000169631.8 selection and upkeep of intraepithelial T cells 5, transcript variant 1 (from RefSeq NM_001167876.1) E9Q072 E9Q072_MOUSE ENSMUST00000169631.1 ENSMUST00000169631.2 ENSMUST00000169631.3 ENSMUST00000169631.4 ENSMUST00000169631.5 ENSMUST00000169631.6 ENSMUST00000169631.7 NM_001167876 Skint5 uc009vcz.1 uc009vcz.2 uc009vcz.3 May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. Membrane ; Multi- pass membrane protein Belongs to the SKINT family. membrane integral component of membrane uc009vcz.1 uc009vcz.2 uc009vcz.3 
ENSMUST00000169652.3 Tifab ENSMUST00000169652.3 TRAF-interacting protein with forkhead-associated domain, family member B, transcript variant 2 (from RefSeq NM_145976.4) ENSMUST00000169652.1 ENSMUST00000169652.2 NM_145976 Q05DP7 Q571I3 Q8JZM6 TIFAB_MOUSE Tifab uc007qsj.1 uc007qsj.2 uc007qsj.3 uc007qsj.4 Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA. Interacts with TIFA. Expressed at high levels in spleen and at moderate levels in lung, thymus, and small intestine. Sequence=BAD90131.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component I-kappaB kinase/NF-kappaB signaling thorax and anterior abdomen determination trigeminal nerve development vestibulocochlear nerve formation peristalsis auditory behavior genitalia morphogenesis inner ear morphogenesis regulation of muscle organ development genitalia development inner ear development neuromuscular process controlling balance mastication cochlea development cochlea morphogenesis craniofacial suture morphogenesis learned vocalization behavior negative regulation of relaxation of muscle negative regulation of saliva secretion hard palate morphogenesis uc007qsj.1 uc007qsj.2 uc007qsj.3 uc007qsj.4 
ENSMUST00000169657.2 B430203G13Rik ENSMUST00000169657.2 B430203G13Rik (from geneSymbol) ENSMUST00000169657.1 uc288fee.1 uc288fee.2 uc288fee.1 uc288fee.2 
ENSMUST00000169670.8 Rsph4a ENSMUST00000169670.8 radial spoke head 4 homolog A (Chlamydomonas) (from RefSeq NM_001162957.1) B2RQN0 ENSMUST00000169670.1 ENSMUST00000169670.2 ENSMUST00000169670.3 ENSMUST00000169670.4 ENSMUST00000169670.5 ENSMUST00000169670.6 ENSMUST00000169670.7 NM_001162957 Q8BYM7 RSH4A_MOUSE Rshl3 uc007euh.1 uc007euh.2 uc007euh.3 Functions as part of axonemal radial spoke complexes that play an important role in ciliary motility (PubMed:32203505, PubMed:34871179). Essential for triplet radial spokes (RS1, RS2 and RS3) head assembly in the motile cilia (PubMed:32203505). Component of the axonemal radial spoke 1 (RS1) and 2 (RS2) complexes, at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the RS1 complex-specific anchor protein IQUB (PubMed:34871179). Interacts with RSPH1 (PubMed:34871179). Interacts with RSPH3B (PubMed:34871179). Interacts with RSPH6A (PubMed:30185526). Interacts with RSPH9 (PubMed:34871179). Cytoplasm, cytoskeleton, cilium axoneme Expressed in the trachea, ependymal cells and oviduct (at protein level) (PubMed:32203505, PubMed:30239614, PubMed:34871179). Abesent from sperm (at protein level) (PubMed:34871179). Expressed in brain, kidney and testis. Mice show hydrocephalus and the tracheal and ependymal cell cilia show clockwise rotation motion instead of planar beating (PubMed:32203505). All three types of radial spoke heads (RS1, RS2 and RS3) are missing in the tracheal cilia (PubMed:32203505). Belongs to the flagellar radial spoke RSP4/6 family. radial spoke cilium movement molecular_function nucleus nucleoplasm nucleolus cytoplasm cytoskeleton cilium axoneme axoneme assembly cell projection cilium assembly cilium movement involved in cell motility uc007euh.1 uc007euh.2 uc007euh.3 
ENSMUST00000169681.3 Eif4b ENSMUST00000169681.3 eukaryotic translation initiation factor 4B (from RefSeq NM_145625.3) ENSMUST00000169681.1 ENSMUST00000169681.2 IF4B_MOUSE NM_145625 Q3TD64 Q8BGD9 uc007xuk.1 uc007xuk.2 uc007xuk.3 Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F (By similarity). Self-associates and interacts with EIF3 p170 subunit. Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex. In response to mTORC1 activation, RPS6KA1-mediated phosphorylation at 'Ser-406' and 'Ser-422' stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function. nucleic acid binding RNA binding translation initiation factor activity cytosol polysome translation translational initiation dendrite RNA strand annealing activity neuronal cell body eukaryotic translation initiation factor 4F complex assembly postsynapse uc007xuk.1 uc007xuk.2 uc007xuk.3 
ENSMUST00000169683.2 Vmn2r35 ENSMUST00000169683.2 vomeronasal 2, receptor 35 (from RefSeq NM_001105067.1) D3YZG0 D3Z0C4 D3Z2B6 E9PWC6 E9PWN9 E9Q076 E9Q1V1 E9Q228 E9Q2E3 E9Q3U0 E9Q7U8 E9Q7U8_MOUSE ENSMUST00000169683.1 F6V5C2 F7A495 NM_001105067 Vmn2r35 Vmn2r51 uc012exw.1 uc012exw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012exw.1 uc012exw.2 
ENSMUST00000169684.2 Prss57 ENSMUST00000169684.2 Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues. (from UniProt Q14B24) AK158376 ENSMUST00000169684.1 PRS57_MOUSE Prssl1 Q14B24 uc287stp.1 uc287stp.2 Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues. Cytoplasmic granule lumen Secreted Note=Stored in cytoplasmic granules and secreted as active enzyme in response to stimulation of neutrophils. After cleavage of the signal peptide, the N-terminus is probably further processed by CTSC. Processing by CTSC is probably required for accumulation in cytoplasmic granules; in the absence of CTSC the protein does not accumulate. N-glycosylated. Belongs to the peptidase S1 family. It is uncertain whether Met-1 or Met-7 is the initiator. serine-type endopeptidase activity extracellular region extracellular space proteolysis heparin binding peptidase activity serine-type peptidase activity hydrolase activity azurophil granule lumen uc287stp.1 uc287stp.2 
ENSMUST00000169686.3 Vmn2r92 ENSMUST00000169686.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N2A4) ENSMUST00000169686.1 ENSMUST00000169686.2 L7N2A4 L7N2A4_MOUSE Vmn2r92 uc009vaw.1 uc009vaw.2 uc009vaw.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vaw.1 uc009vaw.2 uc009vaw.3 
ENSMUST00000169687.8 Gpd2 ENSMUST00000169687.8 glycerol phosphate dehydrogenase 2, mitochondrial, transcript variant 1 (from RefSeq NM_001145820.1) ENSMUST00000169687.1 ENSMUST00000169687.2 ENSMUST00000169687.3 ENSMUST00000169687.4 ENSMUST00000169687.5 ENSMUST00000169687.6 ENSMUST00000169687.7 GPDM_MOUSE Gdm1 Gpd2 NM_001145820 Q3TK51 Q3UDY8 Q61507 Q64521 Q8CBX6 Q8K4U5 Q8VDT0 Q9ERP0 uc008jse.1 uc008jse.2 uc008jse.3 Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta- cell glucose-sensing device. Reaction=a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate; Xref=Rhea:RHEA:18977, ChEBI:CHEBI:24646, ChEBI:CHEBI:57597, ChEBI:CHEBI:57642, ChEBI:CHEBI:132124; EC=1.1.5.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18978; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Calcium-binding enhance the activity of the enzyme. Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1. Mitochondrion inner membrane. Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. glycerol-3-phosphate dehydrogenase [NAD+] activity glycerol-3-phosphate dehydrogenase activity calcium ion binding mitochondrion mitochondrial inner membrane glycerol-3-phosphate metabolic process gluconeogenesis NADH metabolic process glycerol-3-phosphate dehydrogenase complex membrane oxidoreductase activity glycerol catabolic process multicellular organism growth camera-type eye development metal ion binding sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity oxidation-reduction process uc008jse.1 uc008jse.2 uc008jse.3 
ENSMUST00000169689.2 Vmn1r104 ENSMUST00000169689.2 vomeronasal 1 receptor 104 (from RefSeq NM_001166738.1) ENSMUST00000169689.1 L7N293 L7N293_MOUSE NM_001166738 Vmn1r104 uc012fcb.1 uc012fcb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fcb.1 uc012fcb.2 
ENSMUST00000169697.2 Vmn1r142 ENSMUST00000169697.2 vomeronasal 1 receptor 142 (from RefSeq NM_001166749.1) ENSMUST00000169697.1 K7N6U0 K7N6U0_MOUSE NM_001166749 Vmn1r142 uc012fds.1 uc012fds.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fds.1 uc012fds.2 
ENSMUST00000169707.8 Ccnt1 ENSMUST00000169707.8 Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II. (from UniProt Q9QWV9) AK133168 CCNT1_MOUSE ENSMUST00000169707.1 ENSMUST00000169707.2 ENSMUST00000169707.3 ENSMUST00000169707.4 ENSMUST00000169707.5 ENSMUST00000169707.6 ENSMUST00000169707.7 Q3V0G4 Q9QWV9 Q9Z0U7 uc007xmv.1 uc007xmv.2 uc007xmv.3 Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II. Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb (PubMed:27292648). P-TEFb forms a complex with AFF4/AF5Q31 (By similarity). Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin (By similarity). Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin- T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (By similarity). Interacts (via central region) with ZMYND8 (via N- terminus); the interaction is direct and the association appears to occur between homodimeric ZMYND8 and the activated form of the P-TEFb complex (By similarity). Interacts with BRD4, targets chromatin binding (By similarity). Interacts with JMJD6 (By similarity). Interacts with MDFIC (By similarity). Interacts with HSF1. Interacts with HTATSF1 (By similarity). Interacts with TBX21 (PubMed:27292648). Q9QWV9; Q91Y44: Brdt; NbExp=2; IntAct=EBI-2655009, EBI-6260929; Q9QWV9; P28574: Max; NbExp=2; IntAct=EBI-2655009, EBI-1183003; Nucleus The histidine-rich domain (HRD) region is intrinsically disordered and promotes the formation of phase-separated liquid droplets that enhance binding of the P-TEFb complex to the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). ADP-ribosylation on serine residues by PARP1 in response to DNA damage disrupts the phase separation activity of CCNT1, thereby preventing activation of CDK9. Belongs to the cyclin family. Cyclin C subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity DNA binding chromatin binding protein binding nucleus nucleoplasm transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein phosphorylation cell cycle cyclin/CDK positive transcription elongation factor complex transcription factor binding cyclin-dependent protein serine/threonine kinase regulator activity snRNA binding protein kinase binding positive regulation of DNA-templated transcription, elongation transcription regulatory region DNA binding positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription from RNA polymerase II promoter cell division cyclin-dependent protein serine/threonine kinase activator activity RNA polymerase binding 7SK snRNA binding negative regulation of mRNA polyadenylation nucleolus uc007xmv.1 uc007xmv.2 uc007xmv.3 
ENSMUST00000169712.3 Mtfr2 ENSMUST00000169712.3 mitochondrial fission regulator 2 (from RefSeq NM_027930.3) Dufd1 E9PX02 ENSMUST00000169712.1 ENSMUST00000169712.2 Fam54a MTFR2_MOUSE NM_027930 Q8VED8 uc007eny.1 uc007eny.2 uc007eny.3 uc007eny.4 May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission. Mitochondrion Note=Associated with membranes. Expressed predominantly in testis (at protein level). Expressed to a lower extent in spleen. Belongs to the MTFR1 family. mitochondrial fission molecular_function mitochondrion mitochondrion organization aerobic respiration uc007eny.1 uc007eny.2 uc007eny.3 uc007eny.4 
ENSMUST00000169721.3 Zfp641 ENSMUST00000169721.3 zinc finger protein 641, transcript variant 1 (from RefSeq NM_173769.4) ENSMUST00000169721.1 ENSMUST00000169721.2 NM_173769 Q14DN8 Q8BZ34 ZN641_MOUSE Znf641 uc007xme.1 uc007xme.2 uc007xme.3 Transcriptional activator. Activates transcriptional activities of SRE and AP-1 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZ34-1; Sequence=Displayed; Name=2; IsoId=Q8BZ34-2; Sequence=VSP_024869; Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated metal ion binding uc007xme.1 uc007xme.2 uc007xme.3 
ENSMUST00000169730.2 Vmn1r139 ENSMUST00000169730.2 vomeronasal 1 receptor 139 (from RefSeq NM_001166748.1) E9Q1P3 E9Q8L6 E9Q8L6_MOUSE ENSMUST00000169730.1 NM_001166748 Vmn1r132 Vmn1r139 uc012fdq.1 uc012fdq.2 uc012fdq.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fdq.1 uc012fdq.2 uc012fdq.3 
ENSMUST00000169733.8 1700071M16Rik ENSMUST00000169733.8 RIKEN cDNA 1700071M16 gene, transcript variant 1 (from RefSeq NR_045444.1) ENSMUST00000169733.1 ENSMUST00000169733.2 ENSMUST00000169733.3 ENSMUST00000169733.4 ENSMUST00000169733.5 ENSMUST00000169733.6 ENSMUST00000169733.7 NR_045444 uc029thy.1 uc029thy.2 uc029thy.1 uc029thy.2 
ENSMUST00000169754.8 Inpp5d ENSMUST00000169754.8 inositol polyphosphate-5-phosphatase D, transcript variant 1 (from RefSeq NM_010566.3) 7a33 ENSMUST00000169754.1 ENSMUST00000169754.2 ENSMUST00000169754.3 ENSMUST00000169754.4 ENSMUST00000169754.5 ENSMUST00000169754.6 ENSMUST00000169754.7 NM_010566 Q3UPF9 Q4U212 Q61034 Q61173 Q61181 Q9ES52 Q9JKR7 Q9JLF9 Q9JLG0 Q9QVN8 Q9WUC2 SHIP1_MOUSE Ship Ship1 uc007bxc.1 uc007bxc.2 uc007bxc.3 uc007bxc.4 uc007bxc.5 Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (By similarity). Also able to hydrolyze the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:9367159). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad- dependent expression. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + phosphate; Xref=Rhea:RHEA:25528, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57658, ChEBI:CHEBI:57836; EC=3.1.3.86; Evidence= Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol 4-phosphate) + phosphate; Xref=Rhea:RHEA:22764, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456; EC=3.1.3.36; Evidence=; Reaction=1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo- inositol 1,3,4-trisphosphate + phosphate; Xref=Rhea:RHEA:11392, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57895, ChEBI:CHEBI:58414; EC=3.1.3.56; Evidence=; Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane. Interacts with tyrosine phosphorylated form of SHC1 (PubMed:8654924, PubMed:8643691, PubMed:10068665, PubMed:9083021, PubMed:9099679, PubMed:10395202). Interacts with tyrosine phosphorylated form of DOK1 (PubMed:11031258). Interacts with tyrosine phosphorylated form of DOK3 (PubMed:14993273). Interacts with tyrosine phosphorylated form of SLAMF1/CD150 (By similarity). Interacts with PTPN11/SHP-2 in response to IL-3 (PubMed:9110989, PubMed:9393882). Interacts with receptor EPOR (PubMed:10660611). Interacts with receptors MS4A2/FCER1B and FCER1G (By similarity). Interacts with receptors FCGR2B and FCGR3 (PubMed:10395202, PubMed:11016922, PubMed:10779347, PubMed:15456754, PubMed:12393695). Interacts with receptor FCGR2A, leading to regulate gene expression during the phagocytic process (PubMed:12370370). Interacts with GRB2 (PubMed:8643691, PubMed:10068665). Interacts with PLCG1 (PubMed:16000869). Interacts with tyrosine kinases SRC and TEC (PubMed:10794720, PubMed:15492005). Interacts with CRKL (PubMed:11031258). Interacts with c-Met/MET (PubMed:11896575). Interacts with MILR1 (tyrosine-phosphorylated) (PubMed:20526344). Isoform 5 interacts with IL6ST/gp130 (PubMed:17105399). Can weakly interact (via NPXY motif 2) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (PubMed:11247302). Interacts (via SH2 domain) with tyrosine phosphorylated KLRC1 (via ITIM). Q9ES52; Q8CIH5: Plcg2; NbExp=3; IntAct=EBI-300210, EBI-617954; Q9ES52-1; P23727: PIK3R1; Xeno; NbExp=2; IntAct=EBI-1452545, EBI-520244; Cytoplasm Cell membrane ; Peripheral membrane protein Membrane raft Cytoplasm, cytoskeleton Note=Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type (PubMed:12393695). Translocates from the cytoplasm to membrane ruffles in a FCGR3/CD16-dependent manner (PubMed:12393695). Colocalizes with FC-gamma-RIIB receptor (FCGR2B) or FCGR3/CD16 at membrane ruffles (PubMed:12393695). Tyrosine phosphorylation may also participate in membrane localization (PubMed:12393695). [Isoform 5]: Cell membrane ; Peripheral membrane protein Note=Constitutively present at the cell membrane (PubMed:11567986). Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q9ES52-1; Sequence=Displayed; Name=2; IsoId=Q9ES52-2; Sequence=VSP_027981; Name=3; Synonyms=135 kDa SHIP; IsoId=Q9ES52-3; Sequence=VSP_027982; Name=4; Synonyms=SHIPdelta; IsoId=Q9ES52-4; Sequence=VSP_027981, VSP_027983, VSP_027984; Name=5; Synonyms=s-SHIP; IsoId=Q9ES52-5; Sequence=VSP_027980; Name=6; Synonyms=s-SHIPD183; IsoId=Q9ES52-6; Sequence=VSP_027980, VSP_027982; Specifically expressed in immune and hematopoietic cells. Levels vary considerably within this compartment. Lost during erythropoiesis when erythroid cells become Ter119+. Increases substantially with T-cell maturation and when resting B-cells are activated. Also present in mature granulocytes, monocyte/macrophages, mast cells and platelets. Isoform 5 is the only form expressed in embryonic stem (ES) cells and is coexpressed with other isoforms in hematopoietic stem cells, and disappears with differentiation. Expressed in late primitive-streak stage embryos (7.5 dpc), when hematopoiesis is thought to begin, and the expression is restricted to the hematopoietic lineage in embryo. In adults expression continues to be in the majority of cells from hematopoietic origin, including granulocytes, monocytes and lymphocytes, and is also found in the spermatids of the testis. By activin/TGF-beta (at protein level). Regulated by the Smad pathway. Isoform 3 is expressed during myeloid development. The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation. The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative stress. Phosphorylated upon IgG receptor FCGR2B-binding. Mice are viable and fertile. They however fail to thrive and only 40% survive by 14 weeks of age. Mortality is associated with extensive consolidation of the lungs resulting from infiltration by myeloid cells. Increased numbers of granulocyte-macrophage progenitors are observed in both the bone marrow and spleen. Absence of Inpp5d leads to steel factor-induced degranulation of mast cells. They also display increased numbers of osteoclast precursors leading to a severe osteoporosis. [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. immune system process phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity protein binding cytoplasm cytosol cytoskeleton actin filament plasma membrane apoptotic process negative regulation of cell proliferation determination of adult lifespan negative regulation of signal transduction membrane immunoglobulin mediated immune response dephosphorylation hydrolase activity SH3 domain binding inositol-4,5-bisphosphate 5-phosphatase activity negative regulation of granulocyte differentiation cortical cytoskeleton negative regulation of B cell proliferation phosphatidylinositol trisphosphate phosphatase activity intracellular signal transduction positive regulation of apoptotic process membrane raft negative regulation of interleukin-6 biosynthetic process positive regulation of B cell differentiation positive regulation of lymphocyte differentiation positive regulation of erythrocyte differentiation negative regulation of monocyte differentiation negative regulation of neutrophil differentiation negative regulation of osteoclast differentiation negative regulation of bone resorption phosphatidylinositol dephosphorylation negative regulation of immune response negative regulation of B cell activation PTB domain binding inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity uc007bxc.1 uc007bxc.2 uc007bxc.3 uc007bxc.4 uc007bxc.5 
ENSMUST00000169756.8 Gm10376 ENSMUST00000169756.8 predicted gene 10376 (from RefSeq NM_001384185.1) D3YXI8 D3YXI8_MOUSE ENSMUST00000169756.1 ENSMUST00000169756.2 ENSMUST00000169756.3 ENSMUST00000169756.4 ENSMUST00000169756.5 ENSMUST00000169756.6 ENSMUST00000169756.7 Gm10376 Gm10377 NM_001384185 uc288sqr.1 uc288sqr.2 molecular_function cellular_component biological_process uc288sqr.1 uc288sqr.2 
ENSMUST00000169774.2 Vmn1r241 ENSMUST00000169774.2 vomeronasal 1 receptor 241 (from RefSeq NM_001167153.1) ENSMUST00000169774.1 Gm6164 Gm8653 K9J7G2 K9J7G2_MOUSE NM_001167153 Vmn1r241 Vmn1r251 uc012fbs.1 uc012fbs.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fbs.1 uc012fbs.2 
ENSMUST00000169776.3 Mybpc3 ENSMUST00000169776.3 myosin binding protein C, cardiac (from RefSeq NM_008653.3) ENSMUST00000169776.1 ENSMUST00000169776.2 Mybpc3 NM_008653 Q3UIK0 Q3UIK0_MOUSE uc033hoe.1 uc033hoe.2 uc033hoe.3 uc033hoe.4 heart morphogenesis striated muscle myosin thick filament regulation of striated muscle contraction structural constituent of muscle myosin binding sarcomere A band myosin heavy chain binding identical protein binding ventricular cardiac muscle tissue morphogenesis cardiac muscle contraction cardiac myofibril uc033hoe.1 uc033hoe.2 uc033hoe.3 uc033hoe.4 
ENSMUST00000169794.2 Aadacl2 ENSMUST00000169794.2 arylacetamide deacetylase like 2 (from RefSeq NM_001128091.1) Aadacl2 B2RWD2 B2RWD2_MOUSE ENSMUST00000169794.1 NM_001128091 uc012cqa.1 uc012cqa.2 Belongs to the 'GDXG' lipolytic enzyme family. cellular_component catabolic process integral component of membrane hydrolase activity short-chain carboxylesterase activity carboxylic ester hydrolase activity uc012cqa.1 uc012cqa.2 
ENSMUST00000169796.4 Ulbp1 ENSMUST00000169796.4 Ulbp1 (from geneSymbol) AK037408 D2CKI9 D2CKI9_MOUSE ENSMUST00000169796.1 ENSMUST00000169796.2 ENSMUST00000169796.3 J3KMI5 Ulbp1 uc029qvo.1 uc029qvo.2 uc029qvo.3 positive regulation of immune response to tumor cell extracellular space cytosol plasma membrane integral component of plasma membrane immune response external side of plasma membrane actin cytoskeleton membrane integral component of membrane natural killer cell activation positive regulation of interferon-gamma production positive regulation of natural killer cell activation natural killer cell mediated cytotoxicity susceptibility to natural killer cell mediated cytotoxicity positive regulation of macrophage activation positive regulation of nitric oxide biosynthetic process anchored component of plasma membrane natural killer cell lectin-like receptor binding uc029qvo.1 uc029qvo.2 uc029qvo.3 
ENSMUST00000169803.5 Rimbp3 ENSMUST00000169803.5 RIMS binding protein 3 (from RefSeq NM_001033338.3) B9EJ89 E9PZY2 ENSMUST00000169803.1 ENSMUST00000169803.2 ENSMUST00000169803.3 ENSMUST00000169803.4 Gm603 Kiaa1666 NM_001033338 Q3V0F0 Q5DTW0 RIMB3_MOUSE uc007ykn.1 uc007ykn.2 uc007ykn.3 uc007ykn.4 Component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development (PubMed:19091768, PubMed:28003339). Important for male fertility (PubMed:19091768). Interacts with FASLG (By similarity). Interacts with LRGUK (via guanylate kinase-like domain) (PubMed:28003339). Interacts (via C- terminus) with HOOK1 (via coiled-coil region) (PubMed:19091768). Cytoplasm, cytoskeleton Note=In elongating spermatids, localizes to the manchette. Specifically expressed in testis, where it localizes to postmeiotic germ cells (at protein level). Detected in testis from postnatal day 20 onwards (at protein level). In developing spermatozoa, weakly expressed in pachytene spermatocytes and round spermatids, and highly expressed in elongating spermatids (at protein level). Detected in residual bodies but not mature sperm (at protein level). Males are almost completely infertile, but otherwise have no visible phenotype. Sperm morphology is highly abnormal with deformed nuclei, detached acrosomes and an expanded perinuclear space. Defects are first apparent from the round spermatid stage and are associated with abnormal development of the manchette. Belongs to the RIMBP family. Sequence=AAI41387.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE21554.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding nucleus cytoplasm cytoskeleton spermatogenesis spermatid development fertilization cell differentiation benzodiazepine receptor binding manchette neuromuscular synaptic transmission uc007ykn.1 uc007ykn.2 uc007ykn.3 uc007ykn.4 
ENSMUST00000169805.3 Vmn2r90 ENSMUST00000169805.3 vomeronasal 2, receptor 90 (from RefSeq NM_001104539.1) E9PXJ8 E9PXJ8_MOUSE ENSMUST00000169805.1 ENSMUST00000169805.2 NM_001104539 Vmn2r90 uc009vau.1 uc009vau.2 uc009vau.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vau.1 uc009vau.2 uc009vau.3 
ENSMUST00000169807.8 Pcgf2 ENSMUST00000169807.8 polycomb group ring finger 2, transcript variant 3 (from RefSeq NM_001163308.1) ENSMUST00000169807.1 ENSMUST00000169807.2 ENSMUST00000169807.3 ENSMUST00000169807.4 ENSMUST00000169807.5 ENSMUST00000169807.6 ENSMUST00000169807.7 Mel-18 Mel18 NM_001163308 P23798 PCGF2_MOUSE Rnf110 Zfp144 Znf144 uc007lem.1 uc007lem.2 uc007lem.3 Transcriptional repressor (PubMed:8521824). Binds specifically to the DNA sequence 5'-GACTNGACT-3' (PubMed:8521824). Has tumor suppressor activity (PubMed:8521824). May play a role in control of cell proliferation and/or neural cell development (Probable). Regulates proliferation of early T progenitor cells by maintaining expression of HES1(PubMed:15728456). Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (PubMed:8625838, PubMed:15183898). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Exists as both a monomer and homodimer (PubMed:12480532). Component of a PRC1-like complex. Interacts with CBX8, RING1 and RNF2 (By similarity). Interacts with CBX7 (PubMed:22226355). Interacts with PHC2 (PubMed:16024804). P23798; Q60848: Hells; NbExp=2; IntAct=EBI-926857, EBI-3043887; P23798; Q64028: Phc1; NbExp=4; IntAct=EBI-926857, EBI-927346; P23798; Q9QWH1: Phc2; NbExp=5; IntAct=EBI-926857, EBI-642357; P23798; Q9CQJ4: Rnf2; NbExp=15; IntAct=EBI-926857, EBI-927321; Nucleus Expressed in embryonic stem cells (PubMed:22226355). Expressed in a variety of tumor cells and in neural tissues (PubMed:2246278). Developmentally regulated. Phosphorylated. Homodimer formation is regulated by phosphorylation with only unphosphorylated proteins forming homodimers. Note=Probably related to tumorigenesis since it is expressed strongly in most tumor cell lines. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin in utero embryonic development sex chromatin DNA binding chromatin binding protein binding nucleus nucleoplasm chromatin silencing anterior/posterior pattern specification histone acetylation nuclear body PcG protein complex PRC1 complex histone H2A-K119 monoubiquitination metal ion binding embryonic skeletal system morphogenesis embryonic skeletal system development regulation of catalytic activity cellular response to hydrogen peroxide promoter-specific chromatin binding negative regulation of apoptotic signaling pathway ubiquitin-protein transferase activator activity uc007lem.1 uc007lem.2 uc007lem.3 
ENSMUST00000169819.5 Clnk ENSMUST00000169819.5 cytokine-dependent hematopoietic cell linker (from RefSeq NM_013748.3) CLNK_MOUSE ENSMUST00000169819.1 ENSMUST00000169819.2 ENSMUST00000169819.3 ENSMUST00000169819.4 Mist NM_013748 Q8C479 Q9JMJ3 Q9QZE2 uc008xgv.1 uc008xgv.2 uc008xgv.3 uc008xgv.4 An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation (PubMed:10562326, PubMed:10744659, PubMed:11509653, PubMed:12681493). Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (PubMed:15199160, PubMed:16439675). Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells (PubMed:16439675). Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (PubMed:11509653). May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis (PubMed:26009488). Involved in phosphorylation of LAT (PubMed:11463797). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493). When phosphorylated, interacts with PLCG1, PLCG2, GRB2, VAV and LAT (PubMed:10744659, PubMed:11463797). Associated with a tyrosine- phosphorylated polypeptide (p92) in response to immunoreceptor stimulation (PubMed:10562326). Interacts with LBR and AGO2 (PubMed:26009488). Interacts with FGR (PubMed:16439675). Part of a complex consisting of CLNK, SKAP1 and FYB1 (PubMed:12681493). Interacts (via SH2 domain) with FYB1; this interaction allows SKAP1 and FYB1 to promote tyrosine phosphorylation of CLNK by LYN (PubMed:26009488). Interacts (via SH2 domain) with MAP4K1 (PubMed:11509653). Q9QZE2; P14234: Fgr; NbExp=3; IntAct=EBI-8040679, EBI-7587024; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QZE2-1; Sequence=Displayed; Name=2; IsoId=Q9QZE2-2; Sequence=VSP_030334; Expressed in T-cells, mast cells, natural killer and natural killer T cells (at protein level) (PubMed:10744659, PubMed:15199160, PubMed:16439675, PubMed:11509653). Expressed in cytokine-stimulated hemopoietic cells (PubMed:10562326). By cytokines such as IL2 and IL3 (PubMed:10562326, PubMed:15199160, PubMed:16439675). In natural killer T cells, by alpha- galactoceramide (PubMed:16439675). The N-terminal proline-rich region interacts with the SH3 domain of PLCG1. The SH2 domain is important for restoration of BCR-induced calcium response and JNK2 activation in BLNK-deficient DT40 cells expressing LAT. Tyrosine-phosphorylated upon BCR cross-linking (PubMed:10744659, PubMed:11463797). Tyrosine phosphorylation at both Tyr-69 and Tyr-96 are required for BCR-induced calcium response and are essential to restore PLCG2-mediated signaling in BLNK-deficient DT40 cells, but this phosphorylation is dispensable in cells expressing LAT (PubMed:10744659, PubMed:11463797). Interacts with the SH2 domain of PLCG1 via phosphorylated Tyr-96 (PubMed:10744659, PubMed:11463797). Tyrosine phosphorylation is increased when complexed with SKAP1 and FYB1 (PubMed:12681493). No visible phenotype. Sequence=BAC38640.2; Type=Erroneous initiation; Evidence=; positive regulation of natural killer cell cytokine production protein binding cytoplasm transmembrane receptor protein tyrosine kinase signaling pathway regulation of cell death negative regulation of natural killer cell activation intracellular signal transduction uc008xgv.1 uc008xgv.2 uc008xgv.3 uc008xgv.4 
ENSMUST00000169825.8 Cntn1 ENSMUST00000169825.8 contactin 1, transcript variant 2 (from RefSeq NM_007727.3) CNTN1_MOUSE ENSMUST00000169825.1 ENSMUST00000169825.2 ENSMUST00000169825.3 ENSMUST00000169825.4 ENSMUST00000169825.5 ENSMUST00000169825.6 ENSMUST00000169825.7 NM_007727 P12960 Q6NXV7 Q8BR42 Q8C6A0 uc007xim.1 uc007xim.2 uc007xim.3 Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. Monomer. Interacts with CNTNAP1 in cis form (By similarity). Binds to the carbonic-anhydrase like domain of PTPRZ1 (PubMed:20133774). Interacts with NOTCH1 and TNR (PubMed:7678967, PubMed:14567914). Detected in a complex with NRCAM and PTPRB (PubMed:11564762). Interacts with TASOR (PubMed:31112734). Cell membrane; Lipid-anchor, GPI-anchor. Expressed in the ovary and in Sertoli cells of the testis. F3 shares with L1, N-CAM, MAG, and other cell adhesion molecules from nervous tissue the L2/HNK-1 carbohydrate epitope. Belongs to the immunoglobulin superfamily. Contactin family. protein binding plasma membrane cell adhesion Notch signaling pathway nervous system development positive regulation of gene expression positive regulation of sodium ion transport positive regulation of neuron projection development membrane cerebellum development carbohydrate binding neuron projection development anchored component of membrane myelin sheath membrane raft positive regulation of peptidyl-tyrosine phosphorylation anchored component of postsynaptic membrane anchored component of presynaptic membrane uc007xim.1 uc007xim.2 uc007xim.3 
ENSMUST00000169834.2 Nek5 ENSMUST00000169834.2 NIMA (never in mitosis gene a)-related expressed kinase 5, transcript variant 1 (from RefSeq NM_177898.5) ENSMUST00000169834.1 NEK5_MOUSE NM_177898 Q7TSC3 Q8C6N6 Q8CCJ0 uc009lco.1 uc009lco.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7TSC3-1; Sequence=Displayed; Name=2; IsoId=Q7TSC3-2; Sequence=VSP_021531, VSP_021532; Name=3; IsoId=Q7TSC3-3; Sequence=VSP_021533; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding cellular_component protein phosphorylation kinase activity phosphorylation transferase activity metal ion binding positive regulation of striated muscle cell differentiation positive regulation of cysteine-type endopeptidase activity uc009lco.1 uc009lco.2 
ENSMUST00000169838.9 Tiam2 ENSMUST00000169838.9 T cell lymphoma invasion and metastasis 2, transcript variant 2 (from RefSeq NM_001122998.1) ENSMUST00000169838.1 ENSMUST00000169838.2 ENSMUST00000169838.3 ENSMUST00000169838.4 ENSMUST00000169838.5 ENSMUST00000169838.6 ENSMUST00000169838.7 ENSMUST00000169838.8 Kiaa2016 NM_001122998 Q3TSM6 Q3TZ33 Q6AXF2 Q6NXJ2 Q6ZPF3 Q9JLY2 Q9WVS3 Stef TIAM2_MOUSE Tiam2 uc008aeo.1 uc008aeo.2 uc008aeo.3 Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Interacts with MAP1A, MAP1B, PARP1 and YWHAE. Interacts with CD44, PARD3 and MAPK8IP2. Q6ZPF3; P15379: Cd44; NbExp=8; IntAct=EBI-7565978, EBI-7565891; Q6ZPF3; Q8TEW0: PARD3; Xeno; NbExp=2; IntAct=EBI-7565978, EBI-81968; Q6ZPF3; Q8TEW0-2: PARD3; Xeno; NbExp=6; IntAct=EBI-7565978, EBI-9118204; Cytoplasm Cell projection, lamellipodium Cell projection, filopodium Cell projection, growth cone Cell projection, neuron projection rikaryon Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6ZPF3-1; Sequence=Displayed; Name=2; IsoId=Q6ZPF3-2; Sequence=VSP_030977; Name=3; IsoId=Q6ZPF3-3; Sequence=VSP_030976; Name=4; IsoId=Q6ZPF3-4; Sequence=VSP_030978, VSP_030979; Expressed in fetal brain (at protein level). Expressed in the olfactory bulb, cortical plate of the cerebral cortex, caudate putamen, hippocampus, ependymal cells of the lateral surface of the lateral ventricles of the brain. Weakly expressed in heart, lung, liver, skeletal muscle, kidney and testis. Expressed in cerebral cortex, predominantly in the cortical plate and intermediate zone and weakly in the ventricular zone, in neurites and the growth cone of neurites of the hippocampus at 15 dpc (at protein level). Expressed in embryo at 7, 11, 15 and 17 dpc. Expressed in the preplate which consists of the Cajal-Retzius cells and the precursors of subplate neurons, in neurons of the telecephalon, in primordia of cerebral cortex and hippocampus at 12 dpc. Expressed in the cortical plate, striatum and fourth ventricle of the brain, in the cartilaginous tissues including Meckel, costal, vertebral and tracheal cartilage at 14.5 dpc. Expressed in cerebral cortex, hippocampus, olfactory bulbs, rostral migratory pathway and the striatum at 17 dpc. The PH 1 domain and amino acids 619-780 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite- like structure. Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1662 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth. Belongs to the TIAM family. Sequence=BAC98284.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity protein binding cytoplasm signal transduction membrane lamellipodium filopodium growth cone regulation of Rho protein signal transduction intracellular signal transduction cell projection positive regulation of GTPase activity uc008aeo.1 uc008aeo.2 uc008aeo.3 
ENSMUST00000169849.3 1700113H08Rik ENSMUST00000169849.3 RIKEN cDNA 1700113H08 gene (from RefSeq NM_029685.1) 1700113H08Rik E9Q9Q5 E9Q9Q5_MOUSE ENSMUST00000169849.1 ENSMUST00000169849.2 NM_029685 uc011xld.1 uc011xld.2 uc011xld.3 molecular_function cellular_component biological_process uc011xld.1 uc011xld.2 uc011xld.3 
ENSMUST00000169854.2 Sipa1 ENSMUST00000169854.2 signal-induced proliferation associated gene 1, transcript variant 5 (from RefSeq NM_001164568.2) E9Q0Y4 E9Q0Y4_MOUSE ENSMUST00000169854.1 NM_001164568 Sipa1 uc012bgz.1 uc012bgz.2 GTPase activator activity protein C-terminus binding transport vesicle macromolecular complex cellular response to water deprivation positive regulation of GTPase activity regulation of small GTPase mediated signal transduction uc012bgz.1 uc012bgz.2 
ENSMUST00000169860.8 Morf4l1 ENSMUST00000169860.8 mortality factor 4 like 1, transcript variant 2 (from RefSeq NM_024431.3) ENSMUST00000169860.1 ENSMUST00000169860.2 ENSMUST00000169860.3 ENSMUST00000169860.4 ENSMUST00000169860.5 ENSMUST00000169860.6 ENSMUST00000169860.7 MRG15 Morf4l1 NM_024431 Q569V4 Q569V4_MOUSE uc009qzx.1 uc009qzx.2 uc009qzx.3 uc009qzx.4 Nucleus nucleus chromatin organization regulation of transcription, DNA-templated Sin3 complex NuA4 histone acetyltransferase complex uc009qzx.1 uc009qzx.2 uc009qzx.3 uc009qzx.4 
ENSMUST00000169861.9 Shoc2 ENSMUST00000169861.9 Shoc2, leucine rich repeat scaffold protein, transcript variant 2 (from RefSeq NM_001168505.1) ENSMUST00000169861.1 ENSMUST00000169861.2 ENSMUST00000169861.3 ENSMUST00000169861.4 ENSMUST00000169861.5 ENSMUST00000169861.6 ENSMUST00000169861.7 ENSMUST00000169861.8 NM_001168505 O88520 Q3UJH6 Q8BVL0 Q91VH8 SHOC2_MOUSE uc012bnk.1 uc012bnk.2 uc012bnk.3 uc012bnk.4 Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. Interacts with M-Ras/MRAS, and RAF1. Forms a multiprotein complex with Ras (M-Ras/MRAS), Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts with ERBIN; disrupts the interaction with RAF1 and Ras, leading to prevent activation of the Ras signaling pathway. Specifically binds K-Ras/KRAS, M-Ras/MRAS and N- Ras/NRAS but not H-Ras/HRAS. Interacts with LZTR1. Cytoplasm Nucleus Note=Translocates from cytoplasm to nucleus upon growth factor stimulation. Belongs to the SHOC2 family. protein phosphatase type 1 complex nucleus nucleoplasm cytoplasm cytosol protein phosphatase 1 binding protein phosphatase binding positive regulation of Ras protein signal transduction uc012bnk.1 uc012bnk.2 uc012bnk.3 uc012bnk.4 
ENSMUST00000169863.9 Fam169a ENSMUST00000169863.9 family with sequence similarity 169, member A, transcript variant 2 (from RefSeq NM_001146045.1) E9Q0D7 ENSMUST00000169863.1 ENSMUST00000169863.2 ENSMUST00000169863.3 ENSMUST00000169863.4 ENSMUST00000169863.5 ENSMUST00000169863.6 ENSMUST00000169863.7 ENSMUST00000169863.8 F169A_MOUSE Kiaa0888 NM_001146045 Q5XG69 Q69ZW7 uc011zdf.1 uc011zdf.2 uc011zdf.3 Nucleus envelope Nucleus inner membrane ; Peripheral membrane protein ; Nucleoplasmic side Note=Enriched at the nuclear lamina. Belongs to the FAM169 family. Sequence=AAH84589.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAD32329.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component nucleus nuclear envelope nuclear inner membrane biological_process membrane uc011zdf.1 uc011zdf.2 uc011zdf.3 
ENSMUST00000169881.2 Gm17094 ENSMUST00000169881.2 Gm17094 (from geneSymbol) AK133305 ENSMUST00000169881.1 uc290luf.1 uc290luf.2 uc290luf.1 uc290luf.2 
ENSMUST00000169887.2 Gm17057 ENSMUST00000169887.2 Gm17057 (from geneSymbol) ENSMUST00000169887.1 uc289bib.1 uc289bib.2 uc289bib.1 uc289bib.2 
ENSMUST00000169922.9 Chd2 ENSMUST00000169922.9 chromodomain helicase DNA binding protein 2 (from RefSeq NM_001081345.2) CHD2_MOUSE E9PZM4 ENSMUST00000169922.1 ENSMUST00000169922.2 ENSMUST00000169922.3 ENSMUST00000169922.4 ENSMUST00000169922.5 ENSMUST00000169922.6 ENSMUST00000169922.7 ENSMUST00000169922.8 NM_001081345 uc009hrd.1 uc009hrd.2 uc009hrd.3 uc009hrd.4 DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Interacts with MYOD1. Interacts with histone H3.3. Nucleus Note=Binds to myogenic gene promoters. Widely expressed. The CHD1 helical C-terminal domain (CHCT) may bind DNA and nucleosomes. Growth delay late in embryogenesis and perinatal lethality (PubMed:16810678). Heterozygous mice show decreased neonatal viability. Heterozygous mice display glomerulopathy, proteinuria and impaired kidney function. Glomerulopathy may be associated with anemia (PubMed:19142019). Heterozygous mutant also show increased extramedullary hematopoiesis and susceptibility to lymphomas, with defects in hematopoietic stem cell differentiation (PubMed:19137022). nucleotide binding RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding DNA helicase activity helicase activity protein binding ATP binding nucleus nucleoplasm nucleolus chromatin organization cellular response to DNA damage stimulus muscle organ development hydrolase activity DNA duplex unwinding histone binding intracellular membrane-bounded organelle hematopoietic stem cell differentiation uc009hrd.1 uc009hrd.2 uc009hrd.3 uc009hrd.4 
ENSMUST00000169935.2 Akain1 ENSMUST00000169935.2 A kinase anchor inhibitor 1 (from RefSeq NM_001145192.1) AKAI1_MOUSE Akain1 ENSMUST00000169935.1 G3UWD5 NM_001145192 uc008dkx.1 uc008dkx.2 uc008dkx.3 Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A- kinase anchoring protein (AKAP)-mediated subcellular localization of PKA. Binds cAMP-dependent protein kinase (PKA). Interacts specifically with RII-regulatory subunits of PKA (PRKAR2A and PRKAR2B). Preferentially expressed in the neural tissues. The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. cytosol protein localization regulation of protein kinase A signaling negative regulation of protein complex assembly protein kinase A regulatory subunit binding protein kinase A binding uc008dkx.1 uc008dkx.2 uc008dkx.3 
ENSMUST00000169942.10 Pdzrn4 ENSMUST00000169942.10 PDZ domain containing RING finger 4, transcript variant 1 (from RefSeq NM_001164593.1) E9PUZ9 E9PUZ9_MOUSE ENSMUST00000169942.1 ENSMUST00000169942.2 ENSMUST00000169942.3 ENSMUST00000169942.4 ENSMUST00000169942.5 ENSMUST00000169942.6 ENSMUST00000169942.7 ENSMUST00000169942.8 ENSMUST00000169942.9 NM_001164593 Pdzrn4 uc011zye.1 uc011zye.2 uc011zye.3 cellular_component protein ubiquitination ubiquitin protein ligase activity uc011zye.1 uc011zye.2 uc011zye.3 
ENSMUST00000169954.3 Krtap20-2 ENSMUST00000169954.3 keratin associated protein 20-2 (from RefSeq NM_001163615.1) E9Q0A8 E9Q0A8_MOUSE ENSMUST00000169954.1 ENSMUST00000169954.2 Krtap20-2 NM_001163615 uc012aia.1 uc012aia.2 Interacts with hair keratins. molecular_function cellular_component biological_process uc012aia.1 uc012aia.2 
ENSMUST00000169981.2 Gm17111 ENSMUST00000169981.2 Gm17111 (from geneSymbol) ENSMUST00000169981.1 uc288jhd.1 uc288jhd.2 uc288jhd.1 uc288jhd.2 
ENSMUST00000170000.4 Rbm7 ENSMUST00000170000.4 RNA binding motif protein 7, transcript variant 1 (from RefSeq NM_144948.5) ENSMUST00000170000.1 ENSMUST00000170000.2 ENSMUST00000170000.3 NM_144948 Q3UB91 Q7TQE3 Q9CQT2 RBM7_MOUSE Rbm7 uc009pie.1 uc009pie.2 uc009pie.3 uc009pie.4 RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre- mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs). Participates in several biological processes including DNA damage response (DDR) and stress response. During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome. Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability. Component of the nuclear exosome targeting (NEXT) complex composed of MTREX, ZCCHC8, and RBM7 that directs a subset of non-coding short-lived RNAs for exosomal degradation (PubMed:25525152). Interacts with ZCCHC8 and SF3B2/SAP145. Binds to MTREX through ZCCHC8. Interacts with YWHAE and YWHAZ; these interactions are stress-dependent and RBM7 phosphorylation dependent; release RNA from the NEXT complex and may affect RNA targeting to the nuclear RNA exosomome for degradation. Interacts with MEPCE and LARP7, the core subunits of 7SK snRNP; upon genotoxic stress this interaction is enhanced, triggering the release of inactive P-TEFb complex from the core and P-TEFb complex activation (By similarity). Nucleus, nucleoplasm Nucleus Note=Excluded from the nucleolus. The RRM domain mediates RNA binding; the RNA must have four nucleotides for efficient binding. Mediates the interaction of NEXT complex with promoter upstream transcripts (PROMPTs) and potentially aberrant forms of other non coding RNAs, such as snRNAs. The RRM domain exhibits specificity for polyuridine sequences. Phosphorylated at Ser-136 by MAPK14/p38-alpha-activated MAPKAPK2/MK2; this phosphorylation is stress-dependent; this phosphorylation decreases its RNA-binding capacity therefore affecting RNA nuclear exosome-mediated degradation (PubMed:25525152). This phosphorylation mediates YWHAE and YWHAZ interactions (By similarity). regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding single-stranded RNA binding nucleus nucleoplasm meiotic cell cycle uc009pie.1 uc009pie.2 uc009pie.3 uc009pie.4 
ENSMUST00000170013.2 Caps2 ENSMUST00000170013.2 calcyphosphine 2, transcript variant 1 (from RefSeq NM_178278.4) CAYP2_MOUSE E9Q2J8 ENSMUST00000170013.1 G3X9M5 NM_178278 Q8BUG5 Q8C1J6 uc007han.1 uc007han.2 uc007han.3 uc007han.4 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BUG5-1; Sequence=Displayed; Name=2; IsoId=Q8BUG5-2; Sequence=VSP_014411, VSP_014412; Name=3; IsoId=Q8BUG5-3; Sequence=VSP_062160; calcium ion binding cellular_component metal ion binding uc007han.1 uc007han.2 uc007han.3 uc007han.4 
ENSMUST00000170019.3 Gm7008 ENSMUST00000170019.3 Gm7008 (from geneSymbol) AK004585 ENSMUST00000170019.1 ENSMUST00000170019.2 uc029rrz.1 uc029rrz.2 uc029rrz.3 uc029rrz.4 uc029rrz.1 uc029rrz.2 uc029rrz.3 uc029rrz.4 
ENSMUST00000170021.3 Pate1 ENSMUST00000170021.3 prostate and testis expressed 1 (from RefSeq NM_001199953.2) E9Q658 E9Q658_MOUSE ENSMUST00000170021.1 ENSMUST00000170021.2 Gm17252 NM_001199953 Pate1 uc012gqm.1 uc012gqm.2 acetylcholine receptor regulator activity regulation of neurotransmitter receptor activity uc012gqm.1 uc012gqm.2 
ENSMUST00000170026.2 Gm17028 ENSMUST00000170026.2 Gm17028 (from geneSymbol) ENSMUST00000170026.1 uc287upm.1 uc287upm.2 uc287upm.1 uc287upm.2 
ENSMUST00000170030.2 Pate8 ENSMUST00000170030.2 prostate and testis expressed 8 (from RefSeq NM_001167584.1) B3GLJ4 B3GLJ4_MOUSE ENSMUST00000170030.1 Gm17689 NM_001167584 Pate8 uc012gqw.1 uc012gqw.2 uc012gqw.1 uc012gqw.2 
ENSMUST00000170035.8 Alcam ENSMUST00000170035.8 activated leukocyte cell adhesion molecule, transcript variant 2 (from RefSeq NM_001331110.1) Alcam E9Q3Q6 E9Q3Q6_MOUSE ENSMUST00000170035.1 ENSMUST00000170035.2 ENSMUST00000170035.3 ENSMUST00000170035.4 ENSMUST00000170035.5 ENSMUST00000170035.6 ENSMUST00000170035.7 NM_001331110 uc289fab.1 uc289fab.2 Cell projection, axon Cell projection, dendrite membrane integral component of membrane uc289fab.1 uc289fab.2 
ENSMUST00000170047.3 5730435O14Rik ENSMUST00000170047.3 RIKEN cDNA 5730435O14 gene (from RefSeq NR_045341.1) ENSMUST00000170047.1 ENSMUST00000170047.2 NR_045341 uc007exy.1 uc007exy.2 uc007exy.3 uc007exy.1 uc007exy.2 uc007exy.3 
ENSMUST00000170048.2 A930033H14Rik ENSMUST00000170048.2 A930033H14Rik (from geneSymbol) AK084964 ENSMUST00000170048.1 uc007fmn.1 uc007fmn.2 uc007fmn.3 uc007fmn.4 uc007fmn.5 uc007fmn.6 uc007fmn.1 uc007fmn.2 uc007fmn.3 uc007fmn.4 uc007fmn.5 uc007fmn.6 
ENSMUST00000170057.8 Speer1n ENSMUST00000170057.8 Speer1n (from geneSymbol) AY151400 ENSMUST00000170057.1 ENSMUST00000170057.2 ENSMUST00000170057.3 ENSMUST00000170057.4 ENSMUST00000170057.5 ENSMUST00000170057.6 ENSMUST00000170057.7 F6XVS9 F6XVS9_MOUSE Gm8922 uc290tdy.1 uc290tdy.2 uc290tdy.1 uc290tdy.2 
ENSMUST00000170060.4 Zfp839 ENSMUST00000170060.4 zinc finger protein 839, transcript variant 1 (from RefSeq NM_028365.2) E9PUU5 E9PUU5_MOUSE ENSMUST00000170060.1 ENSMUST00000170060.2 ENSMUST00000170060.3 NM_028365 Zfp839 uc011yuu.1 uc011yuu.2 uc011yuu.3 molecular_function nucleic acid binding cellular_component biological_process uc011yuu.1 uc011yuu.2 uc011yuu.3 
ENSMUST00000170085.2 4930445B16Rik ENSMUST00000170085.2 4930445B16Rik (from geneSymbol) AK015387 ENSMUST00000170085.1 uc289yse.1 uc289yse.2 uc289yse.1 uc289yse.2 
ENSMUST00000170086.8 Tap1 ENSMUST00000170086.8 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), transcript variant 1 (from RefSeq NM_013683.2) Abcb2 ENSMUST00000170086.1 ENSMUST00000170086.2 ENSMUST00000170086.3 ENSMUST00000170086.4 ENSMUST00000170086.5 ENSMUST00000170086.6 ENSMUST00000170086.7 Ham-1 Ham1 NM_013683 P21958 Q62427 TAP1_MOUSE uc008cbu.1 uc008cbu.2 uc008cbu.3 uc008cbu.4 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein forms a heterodimer with Tap2 that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]. ABC transporter associated with antigen processing. In complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules. Uses the chemical energy of ATP to export peptides against the concentration gradient. During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle. As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation. Reaction=a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:65972, Rhea:RHEA-COMP:16941, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:166823, ChEBI:CHEBI:456216; EC=7.4.2.14; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65973; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Heterodimer of TAP1 and TAP2 (TAP1-TAP2). A component of the peptide loading complex (PLC), interacts via TAPBP with MHCI heterodimer; this interaction mediates peptide-MHCI assembly. Interacts with PSMB5 and PSMB8. Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=The transmembrane segments seem to form a pore in the membrane. The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. The nucleotide-binding domain (NBD) mediates ATP hydrolysis coupled to peptide translocation. Two ATP molecules are accommodated at distinct nucleotide binding sites (NBS) at TAP1-TAP2 dimer interface. Each NBS is formed by Walker A (GxxGxGKST) and Q-loop motifs from NBD of one subunit, while the NBD from the second subunit completes the active site by contributing the C loop motif (LSGGQ). Each ATP molecule is coordinated via the beta- and gamma-phosphates to a Mg2+ ion, which is necessary for ATP hydrolysis. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. nucleotide binding adaptive immune response immune system process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent ATP binding mitochondrion endoplasmic reticulum endoplasmic reticulum membrane microtubule organizing center defense response protein transport peptide antigen-transporting ATPase activity peptide-transporting ATPase activity peptide transport membrane integral component of membrane ATPase activity antigen processing and presentation of endogenous peptide antigen via MHC class I MHC class Ib protein binding integral component of endoplasmic reticulum membrane phagocytic vesicle membrane protection from natural killer cell mediated cytotoxicity MHC protein binding MHC class I protein binding ATPase activity, coupled to transmembrane movement of substances protein homodimerization activity MHC class I peptide loading complex TAP complex intracellular membrane-bounded organelle ADP binding cytosol to ER transport TAP1 binding TAP2 binding tapasin binding protein heterodimerization activity transmembrane transport peptide transmembrane transporter activity peptide antigen binding uc008cbu.1 uc008cbu.2 uc008cbu.3 uc008cbu.4 
ENSMUST00000170089.8 Gata2 ENSMUST00000170089.8 GATA binding protein 2, transcript variant 2 (from RefSeq NM_001355253.1) ENSMUST00000170089.1 ENSMUST00000170089.2 ENSMUST00000170089.3 ENSMUST00000170089.4 ENSMUST00000170089.5 ENSMUST00000170089.6 ENSMUST00000170089.7 Gata2 NM_001355253 Q3U320 Q3U320_MOUSE uc009cvc.1 uc009cvc.2 uc009cvc.3 Nucleus RNA polymerase II transcription factor activity, sequence-specific DNA binding enhancer sequence-specific DNA binding neuron migration chromatin binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytoplasm transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of cytosolic calcium ion concentration transcription factor binding zinc ion binding positive regulation of gene expression negative regulation of gene expression hemopoiesis response to lipid eosinophil fate commitment positive regulation of mast cell degranulation sequence-specific DNA binding negative regulation of fat cell differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of phagocytosis positive regulation of phagocytosis, engulfment negative regulation of fat cell proliferation C2H2 zinc finger domain binding positive regulation of cell migration involved in sprouting angiogenesis cochlea development positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of neural precursor cell proliferation negative regulation of endothelial cell apoptotic process uc009cvc.1 uc009cvc.2 uc009cvc.3 
ENSMUST00000170094.9 Gm8247 ENSMUST00000170094.9 predicted gene 8068 (from RefSeq NM_001384239.1) ENSMUST00000170094.1 ENSMUST00000170094.2 ENSMUST00000170094.3 ENSMUST00000170094.4 ENSMUST00000170094.5 ENSMUST00000170094.6 ENSMUST00000170094.7 ENSMUST00000170094.8 F6VRJ8 F6VRJ8_MOUSE Gm8247 NM_001384239 uc288svr.1 uc288svr.2 uc288svr.3 molecular_function cellular_component biological_process uc288svr.1 uc288svr.2 uc288svr.3 
ENSMUST00000170103.5 Rab11bos1 ENSMUST00000170103.5 Rab11bos1 (from geneSymbol) AK133808 ENSMUST00000170103.1 ENSMUST00000170103.2 ENSMUST00000170103.3 ENSMUST00000170103.4 uc008bzo.1 uc008bzo.2 uc008bzo.3 uc008bzo.4 uc008bzo.1 uc008bzo.2 uc008bzo.3 uc008bzo.4 
ENSMUST00000170104.3 Gm3411 ENSMUST00000170104.3 predicted gene 3411 (from RefSeq NM_001270812.1) E9PV29 E9PXA1 E9PZ52 E9PZR1 E9Q033 E9Q0W4 E9Q240 E9Q2D9 E9Q2P2 E9Q3U9 E9Q6N8 E9Q7Z2 E9Q932 ENSMUST00000170104.1 ENSMUST00000170104.2 Gm3411 NM_001270812 Q8C7R2 Q8C7R2_MOUSE uc029sew.1 uc029sew.2 molecular_function cellular_component biological_process uc029sew.1 uc029sew.2 
ENSMUST00000170111.3 Kctd6 ENSMUST00000170111.3 potassium channel tetramerisation domain containing 6, transcript variant 1 (from RefSeq NM_001305936.1) ENSMUST00000170111.1 ENSMUST00000170111.2 KCTD6_MOUSE NM_001305936 Q3TXX1 Q8BNL5 uc007sex.1 uc007sex.2 uc007sex.3 uc007sex.4 uc007sex.5 Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu7 probably implicating CUL3-dependent proteasomal degradation. Protein modification; protein ubiquitination. Homopentamer. Interacts with KCTD11; KCTD6 and KCTD11 may associate in heteropentameric assemblies. Interacts (via BTB domain) with CUL3; initially a 4:4 stoichiometry has been reported, however, electron microscopy revealed pentameric states with a five-pointed pinwheel shape. The interaction with CUL3 is indicative for a participation in a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Interacts with HDAC1; probably indirect as the interaction requires the presence of KCTD11. Interacts with USP21 (preferentially catalytic inactive form). Interacts with ANK1 isoform Mu7; detected in striated muscle. Interacts with USP11 (By similarity). Cytoplasm, myofibril, sarcomere, M line Note=Colocalizes with ANK1 isoform Mu7 at the M line in differentiated skeletal muscle cells and heart. Highly expressed in cerebellum and brain. cellular_component cytoplasm ubiquitin-dependent protein catabolic process protein ubiquitination ankyrin binding M band regulation of growth identical protein binding negative regulation of smoothened signaling pathway protein homooligomerization cullin family protein binding uc007sex.1 uc007sex.2 uc007sex.3 uc007sex.4 uc007sex.5 
ENSMUST00000170122.4 Rps27 ENSMUST00000170122.4 ribosomal protein S27, transcript variant 1 (from RefSeq NM_027015.4) ENSMUST00000170122.1 ENSMUST00000170122.2 ENSMUST00000170122.3 NM_027015 Q3TLE3 Q6ZWU9 RS27_MOUSE Rps27 uc008qbl.1 uc008qbl.2 uc008qbl.3 uc008qbl.4 Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Cytoplasm Nucleus, nucleolus Belongs to the eukaryotic ribosomal protein eS27 family. ribosomal small subunit assembly structural constituent of ribosome protein binding nucleus ribosome rRNA processing translation postsynaptic density cytosolic small ribosomal subunit metal ion binding uc008qbl.1 uc008qbl.2 uc008qbl.3 uc008qbl.4 
ENSMUST00000170123.2 Gm10409 ENSMUST00000170123.2 predicted gene 10409 (from RefSeq NR_033121.1) ENSMUST00000170123.1 Gm10409 Gm3020 NR_033121 Q9CZI1 Q9CZI1_MOUSE uc288qho.1 uc288qho.2 molecular_function cellular_component biological_process uc288qho.1 uc288qho.2 
ENSMUST00000170133.8 Gm17231 ENSMUST00000170133.8 Gm17231 (from geneSymbol) ENSMUST00000170133.1 ENSMUST00000170133.2 ENSMUST00000170133.3 ENSMUST00000170133.4 ENSMUST00000170133.5 ENSMUST00000170133.6 ENSMUST00000170133.7 uc292hqj.1 uc292hqj.2 uc292hqj.1 uc292hqj.2 
ENSMUST00000170139.8 Spats2l ENSMUST00000170139.8 spermatogenesis associated, serine-rich 2-like, transcript variant 3 (from RefSeq NM_001368787.1) ENSMUST00000170139.1 ENSMUST00000170139.2 ENSMUST00000170139.3 ENSMUST00000170139.4 ENSMUST00000170139.5 ENSMUST00000170139.6 ENSMUST00000170139.7 NM_001368787 Q8K322 Q8VC37 Q91WJ7 SPS2L_MOUSE uc287ihb.1 uc287ihb.2 Cytoplasm Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91WJ7-1; Sequence=Displayed; Name=2; IsoId=Q91WJ7-2; Sequence=VSP_028793; Belongs to the SPATS2 family. nucleus nucleolus cytoplasm cytosol biological_process macromolecular complex uc287ihb.1 uc287ihb.2 
ENSMUST00000170159.8 Myh2 ENSMUST00000170159.8 myosin, heavy polypeptide 2, skeletal muscle, adult (from RefSeq NM_001039545.2) ENSMUST00000170159.1 ENSMUST00000170159.2 ENSMUST00000170159.3 ENSMUST00000170159.4 ENSMUST00000170159.5 ENSMUST00000170159.6 ENSMUST00000170159.7 G3UW82 G3UW82_MOUSE Myh2 NM_001039545 uc007jmd.1 uc007jmd.2 uc007jmd.3 Muscle contraction. Required for cytoskeleton organization. Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with GCSAM. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. nucleotide binding plasma membrane repair motor activity actin binding ATP binding Golgi apparatus actomyosin contractile ring muscle myosin complex cell-cell junction muscle contraction response to activity myosin complex myofibril A band macromolecular complex actin filament binding actin-mediated cell contraction uc007jmd.1 uc007jmd.2 uc007jmd.3 
ENSMUST00000170166.2 Vmn1r170 ENSMUST00000170166.2 vomeronasal 1 receptor 170 (from RefSeq NM_001166722.1) ENSMUST00000170166.1 K7N6W9 K7N6W9_MOUSE NM_001166722 Vmn1r170 uc012fez.1 uc012fez.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fez.1 uc012fez.2 
ENSMUST00000170188.8 Ptpn21 ENSMUST00000170188.8 protein tyrosine phosphatase, non-receptor type 21, transcript variant 2 (from RefSeq NM_001146199.1) ENSMUST00000170188.1 ENSMUST00000170188.2 ENSMUST00000170188.3 ENSMUST00000170188.4 ENSMUST00000170188.5 ENSMUST00000170188.6 ENSMUST00000170188.7 G5E8J4 G5E8J4_MOUSE NM_001146199 Ptpn21 uc007ore.1 uc007ore.2 uc007ore.3 Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Cytoplasm, cytoskeleton Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytoplasm cytoskeleton protein dephosphorylation dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc007ore.1 uc007ore.2 uc007ore.3 
ENSMUST00000170207.9 Gm8108 ENSMUST00000170207.9 Gm8108 (from geneSymbol) BC016222 ENSMUST00000170207.1 ENSMUST00000170207.2 ENSMUST00000170207.3 ENSMUST00000170207.4 ENSMUST00000170207.5 ENSMUST00000170207.6 ENSMUST00000170207.7 ENSMUST00000170207.8 Gm8108 K7N734 K7N734_MOUSE uc288qix.1 uc288qix.2 uc288qix.3 uc288qix.1 uc288qix.2 uc288qix.3 
ENSMUST00000170214.2 Gm17200 ENSMUST00000170214.2 Gm17200 (from geneSymbol) BC100318 ENSMUST00000170214.1 uc292mqu.1 uc292mqu.2 uc292mqu.1 uc292mqu.2 
ENSMUST00000170215.3 Gm14149 ENSMUST00000170215.3 Gm14149 (from geneSymbol) AK145348 ENSMUST00000170215.1 ENSMUST00000170215.2 uc290bhl.1 uc290bhl.2 uc290bhl.3 uc290bhl.1 uc290bhl.2 uc290bhl.3 
ENSMUST00000170217.8 Farsb ENSMUST00000170217.8 phenylalanyl-tRNA synthetase, beta subunit, transcript variant 9 (from RefSeq NM_001421382.1) ENSMUST00000170217.1 ENSMUST00000170217.2 ENSMUST00000170217.3 ENSMUST00000170217.4 ENSMUST00000170217.5 ENSMUST00000170217.6 ENSMUST00000170217.7 Farsl Farslb Frsb NM_001421382 Q9CWZ8 Q9WUA2 SYFB_MOUSE uc007bqf.1 uc007bqf.2 uc007bqf.3 uc007bqf.4 Reaction=ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe); Xref=Rhea:RHEA:19413, Rhea:RHEA-COMP:9668, Rhea:RHEA-COMP:9699, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58095, ChEBI:CHEBI:78442, ChEBI:CHEBI:78531, ChEBI:CHEBI:456215; EC=6.1.1.20; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19414; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB. Cytoplasm Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. nucleotide binding magnesium ion binding RNA binding aminoacyl-tRNA ligase activity phenylalanine-tRNA ligase activity ATP binding cytoplasm translation phenylalanyl-tRNA aminoacylation phenylalanine-tRNA ligase complex ligase activity protein heterotetramerization uc007bqf.1 uc007bqf.2 uc007bqf.3 uc007bqf.4 
ENSMUST00000170223.9 Adcy4 ENSMUST00000170223.9 adenylate cyclase 4, transcript variant 2 (from RefSeq NM_001361604.1) ADCY4_MOUSE ENSMUST00000170223.1 ENSMUST00000170223.2 ENSMUST00000170223.3 ENSMUST00000170223.4 ENSMUST00000170223.5 ENSMUST00000170223.6 ENSMUST00000170223.7 ENSMUST00000170223.8 NM_001361604 Q91WF3 uc007uau.1 uc007uau.2 uc007uau.3 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro). ; Activated by forskolin. Insensitive to calcium/calmodulin. Stimulated by GNAS and by the G-protein beta and gamma subunit complex. Cell membrane ; Multi-pass membrane protein Cytoplasm The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. nucleotide binding adenylate cyclase activity protein kinase C binding ATP binding nucleus cytoplasm plasma membrane integral component of plasma membrane cAMP biosynthetic process adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity cyclic nucleotide biosynthetic process membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity dendrite G-protein beta/gamma-subunit complex binding macromolecular complex intracellular signal transduction metal ion binding uc007uau.1 uc007uau.2 uc007uau.3 
ENSMUST00000170227.3 Cyp2a22 ENSMUST00000170227.3 cytochrome P450, family 2, subfamily a, polypeptide 22, transcript variant 2 (from RefSeq NM_001421745.1) B2RXZ2 B2RXZ2_MOUSE Cyp2a22 ENSMUST00000170227.1 ENSMUST00000170227.2 NM_001421745 uc012fgf.1 uc012fgf.2 uc012fgf.3 Cytochromes P450 are a group of heme-thiolate monooxygenases. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Endoplasmic reticulum membrane Microsome membrane ; Peripheral membrane protein Membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity coumarin metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc012fgf.1 uc012fgf.2 uc012fgf.3 
ENSMUST00000170239.9 Rpl3l ENSMUST00000170239.9 ribosomal protein L3-like, transcript variant 1 (from RefSeq NM_001163945.2) E9PWZ3 ENSMUST00000170239.1 ENSMUST00000170239.2 ENSMUST00000170239.3 ENSMUST00000170239.4 ENSMUST00000170239.5 ENSMUST00000170239.6 ENSMUST00000170239.7 ENSMUST00000170239.8 NM_001163945 Q5U470 Q9CQ09 RL3L_MOUSE Rpl3l uc008ayf.1 uc008ayf.2 uc008ayf.3 uc008ayf.4 Heart- and skeletal muscle-specific component of the ribosome, which regulates muscle function (PubMed:26684695, PubMed:34081545, PubMed:36517592). Component of the large ribosomal subunit in striated muscle cells: replaces the RPL3 paralog in the ribosome in these cells (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Inhibits myotube growth and muscle function (PubMed:26684695, PubMed:34081545). Component of the large ribosomal subunit (LSU). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11. Interacts with NVL in an ATP-dependent manner. Interacts with RRP1B (By similarity). Interacts with IPO5, IPO7 and KPNB1; these interactions may be involved in RPL5 nuclear import for the assembly of ribosomal subunits (By similarity). Interacts with RRP1B (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9PWZ3-1; Sequence=Displayed; Name=2; IsoId=E9PWZ3-2; Sequence=VSP_061845; Expression is restricted to striated muscles. Expression in skeletal muscle is down-regulated in response to a hypertrophic stimulus. Belongs to the universal ribosomal protein uL3 family. ribosomal large subunit assembly structural constituent of ribosome ribosome translation cytosolic large ribosomal subunit uc008ayf.1 uc008ayf.2 uc008ayf.3 uc008ayf.4 
ENSMUST00000170249.2 Gm4181 ENSMUST00000170249.2 Gm4181 (from geneSymbol) E9Q7X3 E9Q7X3_MOUSE ENSMUST00000170249.1 Gm4181 uc288tpu.1 uc288tpu.2 molecular_function cellular_component biological_process uc288tpu.1 uc288tpu.2 
ENSMUST00000170255.2 Cyp2d11 ENSMUST00000170255.2 cytochrome P450, family 2, subfamily d, polypeptide 11 (from RefSeq NM_001104531.1) CP2DB_MOUSE Cyp2d-11 E9Q750 ENSMUST00000170255.1 NM_001104531 P24457 uc009vas.1 uc009vas.2 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen arachidonic acid metabolic process heme binding organelle membrane exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process aromatase activity uc009vas.1 uc009vas.2 
ENSMUST00000170257.4 Vmn2r86 ENSMUST00000170257.4 vomeronasal 2, receptor 86 (from RefSeq NM_001103365.1) ENSMUST00000170257.1 ENSMUST00000170257.2 ENSMUST00000170257.3 G5E8Y4 G5E8Y4_MOUSE NM_001103365 Vmn2r86 uc009vad.1 uc009vad.2 uc009vad.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vad.1 uc009vad.2 uc009vad.3 
ENSMUST00000170259.3 Cyp11b1 ENSMUST00000170259.3 cytochrome P450, family 11, subfamily b, polypeptide 1 (from RefSeq NM_001033229.3) Cyp11b1 ENSMUST00000170259.1 ENSMUST00000170259.2 NM_001033229 Q3TG86 Q3TG86_MOUSE uc007wge.1 uc007wge.2 uc007wge.3 uc007wge.4 Reaction=21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:76151, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16973, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:195166; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76152; Evidence=; Reaction=21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = corticosterone + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:46104, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16827, ChEBI:CHEBI:16973, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46105; Evidence=; Reaction=a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] = an 11beta- hydroxysteroid + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:15629, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:35341, ChEBI:CHEBI:35346; EC=1.14.15.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15630; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= Belongs to the cytochrome P450 family. regulation of blood volume by renal aldosterone monooxygenase activity steroid 11-beta-monooxygenase activity iron ion binding mitochondrion mitochondrial inner membrane C21-steroid hormone biosynthetic process glucocorticoid biosynthetic process cholesterol metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding aldosterone biosynthetic process cortisol metabolic process metal ion binding corticosterone 18-monooxygenase activity potassium ion homeostasis sodium ion homeostasis oxidation-reduction process cellular response to peptide hormone stimulus uc007wge.1 uc007wge.2 uc007wge.3 uc007wge.4 
ENSMUST00000170260.8 Speer1g ENSMUST00000170260.8 Speer1g (from geneSymbol) ENSMUST00000170260.1 ENSMUST00000170260.2 ENSMUST00000170260.3 ENSMUST00000170260.4 ENSMUST00000170260.5 ENSMUST00000170260.6 ENSMUST00000170260.7 F6R3J9 F6R3J9_MOUSE Gm8879 uc290tcz.1 uc290tcz.2 uc290tcz.1 uc290tcz.2 
ENSMUST00000170267.3 Taar8c ENSMUST00000170267.3 trace amine-associated receptor 8C (from RefSeq NM_001010840.2) B2RT38 ENSMUST00000170267.1 ENSMUST00000170267.2 NM_001010840 Q5QD05 TAA8C_MOUSE uc007eqq.1 uc007eqq.2 uc007eqq.3 uc007eqq.4 Orphan olfactory receptor specific for trace amines. Cell membrane ; Multi-pass membrane protein Specifically expressed in neurons of the olfactory epithelium. Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2- phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine. Belongs to the G-protein coupled receptor 1 family. trace-amine receptor activity G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled amine receptor activity membrane integral component of membrane uc007eqq.1 uc007eqq.2 uc007eqq.3 uc007eqq.4 
ENSMUST00000170275.4 Defa2 ENSMUST00000170275.4 defensin, alpha, 2 (from RefSeq NM_001195634.2) Defa2 Defa33 Defcr20 E9Q4S6 E9Q5P7 ENSMUST00000170275.1 ENSMUST00000170275.2 ENSMUST00000170275.3 NM_001195634 Q8C1N9 Q8C1N9_MOUSE uc029wrp.1 uc029wrp.2 uc029wrp.3 uc029wrp.4 Secreted Belongs to the alpha-defensin family. extracellular region extracellular space defense response defense response to bacterium uc029wrp.1 uc029wrp.2 uc029wrp.3 uc029wrp.4 
ENSMUST00000170301.3 Speer1m ENSMUST00000170301.3 spermatogenesis associated glutamate (E)-rich protein 1M (from RefSeq NM_001177510.1) 4933402N22Rik A3KN63 A3KN63_MOUSE ENSMUST00000170301.1 ENSMUST00000170301.2 Gm6460 NM_001177510 uc008wlv.1 uc008wlv.2 uc008wlv.3 molecular_function cellular_component biological_process uc008wlv.1 uc008wlv.2 uc008wlv.3 
ENSMUST00000170303.2 Nme1nme2 ENSMUST00000170303.2 Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L- histidine.; EC=2.7.13.3; Evidence=; (from UniProt E9PZF0) E9PZF0 E9PZF0_MOUSE ENSMUST00000170303.1 Gm20390 Nme1nme2 X68193 uc288bkh.1 uc288bkh.2 Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L- histidine.; EC=2.7.13.3; Evidence=; Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence= Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm Belongs to the NDK family. nucleotide binding nucleoside diphosphate kinase activity ATP binding purine nucleotide metabolic process nucleoside diphosphate phosphorylation GTP biosynthetic process pyrimidine nucleotide metabolic process UTP biosynthetic process CTP biosynthetic process kinase activity phosphorylation transferase activity uc288bkh.1 uc288bkh.2 
ENSMUST00000170322.3 Vmn2r113 ENSMUST00000170322.3 vomeronasal 2, receptor 113 (from RefSeq NM_001104578.1) E9PZA6 E9PZA6_MOUSE ENSMUST00000170322.1 ENSMUST00000170322.2 NM_001104578 Vmn2r113 uc009vbq.1 uc009vbq.2 uc009vbq.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vbq.1 uc009vbq.2 uc009vbq.3 
ENSMUST00000170335.5 ENSMUSG00000121779 ENSMUST00000170335.5 ENSMUSG00000121779 (from geneSymbol) BC091755 ENSMUST00000170335.1 ENSMUST00000170335.2 ENSMUST00000170335.3 ENSMUST00000170335.4 uc008fbw.1 uc008fbw.2 uc008fbw.3 uc008fbw.4 uc008fbw.1 uc008fbw.2 uc008fbw.3 uc008fbw.4 
ENSMUST00000170341.3 Vmn2r14 ENSMUST00000170341.3 vomeronasal 2, receptor 14, transcript variant 1 (from RefSeq NM_001384975.1) E9Q759 E9Q759_MOUSE ENSMUST00000170341.1 ENSMUST00000170341.2 NM_001384975 Vmn2r14 uc009vdl.1 uc009vdl.2 uc009vdl.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vdl.1 uc009vdl.2 uc009vdl.3 
ENSMUST00000170349.3 Prr23a1 ENSMUST00000170349.3 proline rich 23A, member 1 (from RefSeq NM_001134660.1) ENSMUST00000170349.1 ENSMUST00000170349.2 G3UW32 G3UW32_MOUSE NM_001134660 Prr23a Prr23a1 uc012gyu.1 uc012gyu.2 uc012gyu.3 Belongs to the PRR23 family. molecular_function cellular_component biological_process uc012gyu.1 uc012gyu.2 uc012gyu.3 
ENSMUST00000170374.8 Ampd3 ENSMUST00000170374.8 adenosine monophosphate deaminase 3, transcript variant 2 (from RefSeq NM_001276301.2) AMPD3_MOUSE Ampd3 ENSMUST00000170374.1 ENSMUST00000170374.2 ENSMUST00000170374.3 ENSMUST00000170374.4 ENSMUST00000170374.5 ENSMUST00000170374.6 ENSMUST00000170374.7 NM_001276301 O08739 O88692 Q8CFR4 uc009jfl.1 uc009jfl.2 uc009jfl.3 uc009jfl.4 uc009jfl.5 This gene encodes a member of the adenosine and AMP deaminases family. The encoded protein is an AMP deaminase involved in nucleotide and energy metabolism in erythrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D85596.1, SRR1660811.194922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## AMP deaminase plays a critical role in energy metabolism. Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14778; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. Homotetramer. Found in heart, lung brain, spleen, kidney and to a lesser extent in liver. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. AMP deaminase activity cytosol IMP biosynthetic process nucleotide metabolic process purine ribonucleoside monophosphate biosynthetic process hydrolase activity deaminase activity IMP salvage erythrocyte homeostasis ADP metabolic process AMP metabolic process ATP metabolic process GTP metabolic process metal ion binding energy homeostasis uc009jfl.1 uc009jfl.2 uc009jfl.3 uc009jfl.4 uc009jfl.5 
ENSMUST00000170379.2 ENSMUSG00000121823 ENSMUST00000170379.2 ENSMUSG00000121823 (from geneSymbol) ENSMUST00000170379.1 uc289imt.1 uc289imt.2 uc289imt.1 uc289imt.2 
ENSMUST00000170382.5 Lsm5 ENSMUST00000170382.5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated (from RefSeq NM_025520.3) A2RTT1 ENSMUST00000170382.1 ENSMUST00000170382.2 ENSMUST00000170382.3 ENSMUST00000170382.4 LSM5_MOUSE NM_025520 P62322 uc009cbj.1 uc009cbj.2 uc009cbj.3 uc009cbj.4 Plays a role in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Nucleus Belongs to the snRNP Sm proteins family. mRNA splicing, via spliceosome RNA binding protein binding nucleus spliceosomal complex U6 snRNP cytoplasm mRNA processing mRNA catabolic process RNA splicing response to bacterium U4/U6 x U5 tri-snRNP complex protein heterodimerization activity U2-type precatalytic spliceosome Lsm1-7-Pat1 complex uc009cbj.1 uc009cbj.2 uc009cbj.3 uc009cbj.4 
ENSMUST00000170396.3 Ascl4 ENSMUST00000170396.3 achaete-scute family bHLH transcription factor 4 (from RefSeq NM_001163614.2) Ascl4 ENSMUST00000170396.1 ENSMUST00000170396.2 M0QW46 M0QW46_MOUSE NM_001163614 uc011xkr.1 uc011xkr.2 uc011xkr.3 negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding DNA binding regulation of transcription from RNA polymerase II promoter transcription factor binding protein dimerization activity RNA polymerase II transcription factor complex transcription factor activity, sequence-specific DNA binding uc011xkr.1 uc011xkr.2 uc011xkr.3 
ENSMUST00000170402.4 Vmn2r36 ENSMUST00000170402.4 vomeronasal 2, receptor 36 (from RefSeq NM_001105068.1) ENSMUST00000170402.1 ENSMUST00000170402.2 ENSMUST00000170402.3 K7N741 K7N741_MOUSE NM_001105068 Vmn2r36 uc012exx.1 uc012exx.2 uc012exx.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012exx.1 uc012exx.2 uc012exx.3 
ENSMUST00000170419.3 Vmn2r9 ENSMUST00000170419.3 vomeronasal 2, receptor 9, transcript variant 2 (from RefSeq NM_001385191.1) ENSMUST00000170419.1 ENSMUST00000170419.2 K7N6Z8 K7N6Z8_MOUSE NM_001385191 Vmn2r9 uc290yav.1 uc290yav.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc290yav.1 uc290yav.2 
ENSMUST00000170424.3 Vmn2r98 ENSMUST00000170424.3 vomeronasal 2, receptor 98 (from RefSeq NM_001104550.1) E9PZ56 E9PZ56_MOUSE ENSMUST00000170424.1 ENSMUST00000170424.2 NM_001104550 Vmn2r98 uc009vbd.1 uc009vbd.2 uc009vbd.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vbd.1 uc009vbd.2 uc009vbd.3 
ENSMUST00000170428.3 Ifna11 ENSMUST00000170428.3 interferon alpha 11 (from RefSeq NM_008333.2) ENSMUST00000170428.1 ENSMUST00000170428.2 IFNAB_MOUSE NM_008333 Q61716 Q810G4 uc008tny.1 uc008tny.2 uc008tny.3 uc008tny.4 Has antiviral and antiproliferative activities (PubMed:15254193). Produced by macrophages and stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase (By similarity). During viral infection, mediates antiviral effect, either directly by inducing interferon-stimulated genes, either indirectly through stimulation of natural killer cells enabling them to control viral replication (PubMed:22912583). Secreted N-glycosylated (PubMed:15254193). Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response negative regulation of cell proliferation cytokine-mediated signaling pathway natural killer cell activation B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tny.1 uc008tny.2 uc008tny.3 uc008tny.4 
ENSMUST00000170430.3 Pik3c2a ENSMUST00000170430.3 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha (from RefSeq NM_011083.2) ENSMUST00000170430.1 ENSMUST00000170430.2 F8VPL2 F8VPL2_MOUSE NM_011083 Pik3c2a uc009jjg.1 uc009jjg.2 uc009jjg.3 Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:18373, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57658, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216; EC=2.7.1.154; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18374; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+); Xref=Rhea:RHEA:12709, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088, ChEBI:CHEBI:456216; EC=2.7.1.137; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12710; Evidence=; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. nucleus cytoplasm plasma membrane endocytosis kinase activity phosphorylation transferase activity vesicle phosphatidylinositol 3-kinase activity phosphatidylinositol binding phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling positive regulation of cell migration involved in sprouting angiogenesis uc009jjg.1 uc009jjg.2 uc009jjg.3 
ENSMUST00000170435.2 Sardhos ENSMUST00000170435.2 Sardhos (from geneSymbol) ENSMUST00000170435.1 uc289uii.1 uc289uii.2 uc289uii.1 uc289uii.2 
ENSMUST00000170489.2 Ddx6 ENSMUST00000170489.2 DEAD-box helicase 6, transcript variant 5 (from RefSeq NM_001357703.1) DDX6_MOUSE ENSMUST00000170489.1 Hlr2 NM_001357703 O54979 P54823 Q3UFI3 Q8BW68 Rck uc012grw.1 uc012grw.2 Essential for the formation of P-bodies, cytosolic membrane- less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (By similarity). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (By similarity). In the process of mRNA degradation, plays a role in mRNA decapping (By similarity). Blocks autophagy in nutrient- rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Interacts with LSM14A, LSM14B, EIF4ENIF1/4E-T, PATL1, EDC3 and EDC4 (By similarity). Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS (By similarity). Interacts with LIMD1, WTIP and AJUBA (By similarity). Interacts with APOBEC3G in an RNA-dependent manner (By similarity). Interacts with RC3H1 (PubMed:20639877). Interacts with ATXN2L (By similarity). Interacts with MCRIP1 (By similarity). Interacts with MCRIP2 (By similarity). Interacts with NUFIP2 (By similarity). Interacts with TRIM71 (via NHL repeats) in an RNA- dependent manner (By similarity). Interacts with GIGYF1 and GIGYF2 (By similarity). Cytoplasm, P-body Cytoplasm Nucleus Note=Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism. Upon cellular stress, relocalizes to stress granules. Abundant expression in growing oocytes, levels decline in primary and secondary oocytes, and degradation appears to be complete by the mid-late two-cell stage. Sumoylated. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. nucleotide binding heterochromatin P-body outer dense fiber nucleic acid binding RNA binding RNA helicase activity mRNA binding helicase activity ATP binding nucleus nucleolus cytoplasm mitochondrion cytosol cell-cell adherens junction spermatogenesis cytoplasmic stress granule RISC complex hydrolase activity viral RNA genome packaging stem cell population maintenance protein domain specific binding chromatoid body cytoplasmic mRNA processing body assembly stress granule assembly cytoplasmic ribonucleoprotein granule negative regulation of neuron differentiation perinuclear region of cytoplasm spermatid differentiation sperm annulus uc012grw.1 uc012grw.2 
ENSMUST00000170511.3 BC035947 ENSMUST00000170511.3 BC035947 (from geneSymbol) AK032005 B2RQY6 B2RQY6_MOUSE BC035947 ENSMUST00000170511.1 ENSMUST00000170511.2 uc011wnt.1 uc011wnt.2 uc011wnt.3 membrane integral component of membrane uc011wnt.1 uc011wnt.2 uc011wnt.3 
ENSMUST00000170517.9 Ints14 ENSMUST00000170517.9 integrator complex subunit 14, transcript variant 7 (from RefSeq NM_001416265.1) ENSMUST00000170517.1 ENSMUST00000170517.2 ENSMUST00000170517.3 ENSMUST00000170517.4 ENSMUST00000170517.5 ENSMUST00000170517.6 ENSMUST00000170517.7 ENSMUST00000170517.8 INT14_MOUSE Ints14 NM_001416265 Q3THM0 Q3V323 Q3V3E8 Q8C072 Q8R3P6 Vwa9 uc009qcn.1 uc009qcn.2 uc009qcn.3 uc009qcn.4 Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R3P6-1; Sequence=Displayed; Name=2; IsoId=Q8R3P6-2; Sequence=VSP_027182, VSP_027183; Belongs to the INTS14 family. Sequence=BAC27696.1; Type=Frameshift; Evidence=; molecular_function nucleus integrator complex snRNA 3'-end processing uc009qcn.1 uc009qcn.2 uc009qcn.3 uc009qcn.4 
ENSMUST00000170518.3 Tarbp1 ENSMUST00000170518.3 TAR RNA binding protein 1 (from RefSeq NM_001159907.1) E9Q368 E9Q368_MOUSE ENSMUST00000170518.1 ENSMUST00000170518.2 NM_001159907 Tarbp1 uc012gne.1 uc012gne.2 uc012gne.3 RNA binding RNA processing RNA methyltransferase activity tRNA (guanine) methyltransferase activity tRNA methylation uc012gne.1 uc012gne.2 uc012gne.3 
ENSMUST00000170521.8 Gm2888 ENSMUST00000170521.8 Gm2888 (from geneSymbol) ENSMUST00000170521.1 ENSMUST00000170521.2 ENSMUST00000170521.3 ENSMUST00000170521.4 ENSMUST00000170521.5 ENSMUST00000170521.6 ENSMUST00000170521.7 Gm2888 K7N746 K7N746_MOUSE uc288qgq.1 uc288qgq.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qgq.1 uc288qgq.2 
ENSMUST00000170546.8 Gm8159 ENSMUST00000170546.8 Gm8159 (from geneSymbol) E9Q0R1 E9Q0R1_MOUSE ENSMUST00000170546.1 ENSMUST00000170546.2 ENSMUST00000170546.3 ENSMUST00000170546.4 ENSMUST00000170546.5 ENSMUST00000170546.6 ENSMUST00000170546.7 Gm8159 uc288qkh.1 uc288qkh.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qkh.1 uc288qkh.2 
ENSMUST00000170552.6 Supt20 ENSMUST00000170552.6 SPT20 SAGA complex component, transcript variant 3 (from RefSeq NM_019995.5) D3Ertd300e ENSMUST00000170552.1 ENSMUST00000170552.2 ENSMUST00000170552.3 ENSMUST00000170552.4 ENSMUST00000170552.5 Fam48a NM_019995 Q7TT00 Q8BG53 Q9JLS9 SP20H_MOUSE Supt20h uc008pfl.1 uc008pfl.2 uc008pfl.3 Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy. Interacts with ATG9A (By similarity). Interacts with MAPK14. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7TT00-1; Sequence=Displayed; Name=2; IsoId=Q7TT00-2; Sequence=VSP_014880; Name=3; IsoId=Q7TT00-3; Sequence=VSP_014881, VSP_014882; Ubiquitously expressed throughout development. Mice show gastrulation defects in which mesoderm migration is defective due to deficiency in E-cadherin protein down- regulation in the primitive streak. A weaker mutation named droopy eye (drey), which affects splicing causes incompletely penetrant defects in neural tube closure, eye development and gastrulation. Belongs to the SPT20 family. SAGA complex fibrillar center transcription cofactor activity regulation of transcription from RNA polymerase II promoter multicellular organism development gastrulation positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter SAGA-type complex uc008pfl.1 uc008pfl.2 uc008pfl.3 
ENSMUST00000170556.8 Pycr1 ENSMUST00000170556.8 Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. (from UniProt Q922W5) AK139185 ENSMUST00000170556.1 ENSMUST00000170556.2 ENSMUST00000170556.3 ENSMUST00000170556.4 ENSMUST00000170556.5 ENSMUST00000170556.6 ENSMUST00000170556.7 P5CR1_MOUSE Q922W5 uc007mtv.1 uc007mtv.2 Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. Reaction=L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH; Xref=Rhea:RHEA:14109, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60039; EC=1.5.1.2; Evidence=; Reaction=L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:14105, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60039; EC=1.5.1.2; Evidence=; Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. Homodecamer; composed of 5 homodimers. Interacts with LTO1. Mitochondrion Highly expressed in osteoblasts and skin. Belongs to the pyrroline-5-carboxylate reductase family. pyrroline-5-carboxylate reductase activity mitochondrion proline biosynthetic process cellular amino acid biosynthetic process oxidoreductase activity cellular response to oxidative stress identical protein binding regulation of mitochondrial membrane potential oxidation-reduction process L-proline biosynthetic process negative regulation of hydrogen peroxide-induced cell death uc007mtv.1 uc007mtv.2 
ENSMUST00000170557.2 Gm17035 ENSMUST00000170557.2 Gm17035 (from geneSymbol) ENSMUST00000170557.1 uc288ylz.1 uc288ylz.2 uc288ylz.1 uc288ylz.2 
ENSMUST00000170578.3 Rgmb ENSMUST00000170578.3 repulsive guidance molecule family member B, transcript variant 5 (from RefSeq NM_178615.4) ENSMUST00000170578.1 ENSMUST00000170578.2 NM_178615 Q501K0 Q7TQ33 Q8BNR6 Q8CBM7 RGMB_MOUSE Rgmb uc057biy.1 uc057biy.2 uc057biy.3 Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system. Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling. Promotes neuronal adhesion. May inhibit neurite outgrowth (By similarity). Homooligomer. Interacts with DRGX. Interacts with BMP2 and BMP4. Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B. The functional complex with its receptor NEO1/neogenin appears to be a heterotetramer with a 2:2 stoichiometry, RGM molecules acting as staples that bring two NEO1 receptors together without interacting themselves, this arrangement leads to activation of downstream signaling via RhoA. Cell membrane ; Lipid-anchor, GPI-anchor Membrane raft Detected in neonatal and adult dorsal root ganglion sensory neurons, spinal cord, and brain (at protein level). Also expressed at high levels in retinal ganglion cells of developing mouse, extending to the optic nerve (at protein level). Expressed in testis, epididymis, ovary, uterus, and pituitary. Expressed in the developing nervous system. Expression is restricted to a subset of individual neurons in the mid- and hindbrain regions. At 10.5 dpc, expression level increases and extends further into the forebrain. The segmented pattern of expression becomes more refined and is indicative of peripheral nervous system labelling. Not detected in the area of motoneuron differentiation. Expression could be restricted to postmitotic neurons. Also expressed in fetal dorsal root ganglion, dorsal horn, in the dorsomedial mantle layer of the spinal cord, alar plate of the myelencephalon, marginal layer of the mesencephalon, basal plate of the pons, and cerebellar primordia, as well as the cortex of the olfactory lobe, retina, and olfactory epithelium. In the developing eye, expressed in differentiating ganglion cells and later in the development, also in amacrine cells. In adult, expressed in scattered cells throughout the brain. GPI-anchored. Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. Belongs to the repulsive guidance molecule (RGM) family. endoplasmic reticulum-Golgi intermediate compartment plasma membrane cell adhesion signal transduction coreceptor activity membrane BMP signaling pathway anchored component of membrane identical protein binding membrane raft positive regulation of transcription, DNA-templated anchored component of plasma membrane uc057biy.1 uc057biy.2 uc057biy.3 
ENSMUST00000170579.9 Mfsd4b5 ENSMUST00000170579.9 major facilitator superfamily domain containing 4B5, transcript variant 1 (from RefSeq NM_001113385.1) BC021785 E9PYY6 E9PYY6_MOUSE ENSMUST00000170579.1 ENSMUST00000170579.2 ENSMUST00000170579.3 ENSMUST00000170579.4 ENSMUST00000170579.5 ENSMUST00000170579.6 ENSMUST00000170579.7 ENSMUST00000170579.8 Mfsd4b5 NM_001113385 uc011xcx.1 uc011xcx.2 uc011xcx.3 uc011xcx.4 Membrane ; Multi- pass membrane protein glucose transmembrane transporter activity cellular_component integral component of plasma membrane cation transport cation transmembrane transporter activity membrane integral component of membrane transmembrane transport cation transmembrane transport glucose transmembrane transport uc011xcx.1 uc011xcx.2 uc011xcx.3 uc011xcx.4 
ENSMUST00000170580.3 Kcnf1 ENSMUST00000170580.3 potassium voltage-gated channel, subfamily F, member 1 (from RefSeq NM_201531.5) ENSMUST00000170580.1 ENSMUST00000170580.2 KCNF1_MOUSE NM_201531 Q7TSH7 uc007ncn.1 uc007ncn.2 uc007ncn.3 Putative voltage-gated potassium channel. Heteromultimer with KCNG3, KCNG4 and KCNV2. Interacts with DLG1 (By similarity). Membrane ; Multi-pass membrane protein The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane regulation of ion transmembrane transport protein homooligomerization transmembrane transport potassium ion transmembrane transport uc007ncn.1 uc007ncn.2 uc007ncn.3 
ENSMUST00000170588.8 Smtn ENSMUST00000170588.8 smoothelin, transcript variant 1 (from RefSeq NM_001159284.2) ENSMUST00000170588.1 ENSMUST00000170588.2 ENSMUST00000170588.3 ENSMUST00000170588.4 ENSMUST00000170588.5 ENSMUST00000170588.6 ENSMUST00000170588.7 NM_001159284 Q3TCV2 Q6NSW1 Q8CD93 Q921U8 Q9JHG8 Q9JLU7 Q9R0D0 Q9R253 Q9Z0Q2 SMTN_MOUSE Smsmo uc007htg.1 uc007htg.2 uc007htg.3 uc007htg.4 Structural protein of the cytoskeleton. Cytoplasm, cytoskeleton Note=Exhibits a filamentous organization. Event=Alternative splicing; Named isoforms=4; Name=L1; Synonyms=B; IsoId=Q921U8-1; Sequence=Displayed; Name=L2; IsoId=Q921U8-2; Sequence=VSP_031244; Name=S1; Synonyms=A; IsoId=Q921U8-3; Sequence=VSP_031243; Name=S2; IsoId=Q921U8-4; Sequence=VSP_031243, VSP_031244; Belongs to the smoothelin family. negative regulation of systemic arterial blood pressure actin binding cytoplasm microtubule organizing center cytoskeleton actin cytoskeleton organization filamentous actin positive regulation of cardiac muscle contraction uc007htg.1 uc007htg.2 uc007htg.3 uc007htg.4 
ENSMUST00000170596.4 Vmn2r82 ENSMUST00000170596.4 vomeronasal 2, receptor 82 (from RefSeq NM_001101572.1) ENSMUST00000170596.1 ENSMUST00000170596.2 ENSMUST00000170596.3 G3UWA2 G3UWA2_MOUSE NM_001101572 Vmn2r82 uc009vaa.1 uc009vaa.2 uc009vaa.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane neuron differentiation G-protein coupled olfactory receptor activity signaling receptor activity detection of chemical stimulus involved in sensory perception of smell uc009vaa.1 uc009vaa.2 uc009vaa.3 
ENSMUST00000170608.8 Qrfprl ENSMUST00000170608.8 pyroglutamylated RFamide peptide receptor like (from RefSeq NM_175524.4) C130060K24Rik ENSMUST00000170608.1 ENSMUST00000170608.2 ENSMUST00000170608.3 ENSMUST00000170608.4 ENSMUST00000170608.5 ENSMUST00000170608.6 ENSMUST00000170608.7 G3UWA8 G3UWA8_MOUSE NM_175524 Qrfprl uc009cef.1 uc009cef.2 uc009cef.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity neuropeptide Y receptor activity signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway membrane integral component of membrane uc009cef.1 uc009cef.2 uc009cef.3 
ENSMUST00000170618.8 Or10ad1 ENSMUST00000170618.8 olfactory receptor family 10 subfamily AD member 1 (from RefSeq NM_001011780.1) E9PZS7 E9PZS7_MOUSE ENSMUST00000170618.1 ENSMUST00000170618.2 ENSMUST00000170618.3 ENSMUST00000170618.4 ENSMUST00000170618.5 ENSMUST00000170618.6 ENSMUST00000170618.7 NM_001011780 Olfr287 Or10ad1 uc011zyt.1 uc011zyt.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. ##Evidence-Data-START## Transcript exon combination :: DR065538.1, SRR1660811.73881.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc011zyt.1 uc011zyt.2 
ENSMUST00000170625.8 Tmem40 ENSMUST00000170625.8 transmembrane protein 40, transcript variant 3 (from RefSeq NM_001168257.1) E9Q6I9 E9Q6I9_MOUSE ENSMUST00000170625.1 ENSMUST00000170625.2 ENSMUST00000170625.3 ENSMUST00000170625.4 ENSMUST00000170625.5 ENSMUST00000170625.6 ENSMUST00000170625.7 NM_001168257 Tmem40 uc012eqo.1 uc012eqo.2 uc012eqo.3 uc012eqo.4 uc012eqo.5 membrane integral component of membrane uc012eqo.1 uc012eqo.2 uc012eqo.3 uc012eqo.4 uc012eqo.5 
ENSMUST00000170629.3 Gtse1 ENSMUST00000170629.3 G two S phase expressed protein 1, transcript variant 3 (from RefSeq NR_177978.1) B99 ENSMUST00000170629.1 ENSMUST00000170629.2 GTSE1_MOUSE NR_177978 O89015 Q8R080 Q9CSG9 uc007xdp.1 uc007xdp.2 uc007xdp.3 May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression. Cytoplasm, cytoskeleton. Note=Associated with microtubules. Expression begins at S phase, accumulates in late S/G2 phase and disappears in G1 phase. By p53 when exposed to different DNA damaging agents, including gamma irradiation and chemotherapeutic drugs. Phosphorylated in mitosis. cytoplasm cytoskeleton microtubule cytoplasmic microtubule uc007xdp.1 uc007xdp.2 uc007xdp.3 
ENSMUST00000170636.2 Gm17133 ENSMUST00000170636.2 Gm17133 (from geneSymbol) ENSMUST00000170636.1 uc289mik.1 uc289mik.2 uc289mik.1 uc289mik.2 
ENSMUST00000170639.2 Gm3043 ENSMUST00000170639.2 Gm3043 (from geneSymbol) ENSMUST00000170639.1 Gm10408 Gm3043 K7N693 K7N693_MOUSE uc288qhz.1 uc288qhz.2 molecular_function cellular_component biological_process uc288qhz.1 uc288qhz.2 
ENSMUST00000170650.3 Rergl ENSMUST00000170650.3 RERG/RAS-like (from RefSeq NM_001128090.1) B2RVE2 B2RVE2_MOUSE ENSMUST00000170650.1 ENSMUST00000170650.2 NM_001128090 Rergl uc012evb.1 uc012evb.2 uc012evb.3 Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; Belongs to the small GTPase superfamily. Ras family. nucleotide binding molecular_function GTPase activity GTP binding cellular_component signal transduction biological_process membrane uc012evb.1 uc012evb.2 uc012evb.3 
ENSMUST00000170651.2 Dnah8 ENSMUST00000170651.2 Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. (from UniProt Q91XQ0) AF356520 DYH8_MOUSE Dnahc8 E9Q010 ENSMUST00000170651.1 O08830 Q3V0D2 Q91V63 Q91XP8 Q91XP9 Q91XQ0 Q99MH8 Q9QY72 uc289jnh.1 uc289jnh.2 Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. Consists of at least two heavy chains and a number of intermediate and light chains. Cytoplasm, cytoskeleton, flagellum axoneme Cytoplasm Note=Detected in sperm tail, with almost exclusive localization to the principal piece. Also detected in the cytoplasm of primary spermatocytes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91XQ0-1; Sequence=Displayed; Name=2; IsoId=Q91XQ0-2; Sequence=VSP_022616, VSP_022617; Isoform 1 and/or isoform 2 are expressed in spermatocytes and mature sperm (at protein level). Testis-specific. Accumulates exclusively in mid to late spermatocytes. Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function. Homozygous knockout male mice are sterile due to diminished sperm movement (PubMed:32619401). Sperm flagella show disorganized microtubules and outer dense fibers resulting in significantly higher rates of abnormal flagella (PubMed:32619401). [Isoform 2]: May be due to an intron retention. Belongs to the dynein heavy chain family. Sequence=BAE21572.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding motor activity microtubule motor activity ATP binding cytoplasm cytoskeleton microtubule cilium microtubule-based movement ATP-dependent microtubule motor activity, minus-end-directed dynein complex motile cilium outer dynein arm outer dynein arm assembly cell projection dynein intermediate chain binding dynein light intermediate chain binding sperm principal piece uc289jnh.1 uc289jnh.2 
ENSMUST00000170653.9 Arhgef2 ENSMUST00000170653.9 Rho/Rac guanine nucleotide exchange factor 2, transcript variant 4 (from RefSeq NM_001198913.2) ARHG2_MOUSE E9QNW9 ENSMUST00000170653.1 ENSMUST00000170653.2 ENSMUST00000170653.3 ENSMUST00000170653.4 ENSMUST00000170653.5 ENSMUST00000170653.6 ENSMUST00000170653.7 ENSMUST00000170653.8 Kiaa0651 Lbcl1 Lfc NM_001198913 O09115 Q3TBI4 Q3TJ16 Q60875 Q8CHE1 Q923E0 Q9ESG7 uc008pvy.1 uc008pvy.2 uc008pvy.3 uc008pvy.4 Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (PubMed:28453519). Found in a complex composed at least of ARHGEF2, NOD2 and RIPK2. Interacts with RIPK2; the interaction mediates tyrosine phosphorylation of RIPK2 by Src kinase CSK. Interacts with RIPK1 and RIPK3. Interacts with YWHAZ/14-3-3 zeta; when phosphorylated at Ser- 885. Interacts with the kinases PAK4, AURKA and MAPK1. Interacts with RHOA and RAC1. Interacts with NOD1 (By similarity). Interacts (via the N- terminal zinc finger) with CAPN6 (via domain II). Interacts with DYNLT1. Q60875; Q61097: Ksr1; NbExp=5; IntAct=EBI-772191, EBI-1536336; Cytoplasm, cytoskeleton Cytoplasm Cell junction, tight junction Golgi apparatus Cytoplasm, cytoskeleton, spindle Cytoplasmic vesicle Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization (By similarity). Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (By similarity). Associated with apical intercellular junctions in the trophectoderm of the blastocyst (PubMed:12604587). Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q60875-1; Sequence=Displayed; Name=2; IsoId=Q60875-2; Sequence=VSP_022641; Name=3; IsoId=Q60875-3; Sequence=VSP_022640, VSP_022642, VSP_022643; Name=4; IsoId=Q60875-4; Sequence=VSP_034962; Name=5; IsoId=Q60875-5; Sequence=VSP_034962, VSP_034963; Ubiquitous, with the exception of liver tissue. Levels are high in hemopoietic tissues (thymus, spleen, bone marrow) as well as in kidney and lung. Expressed in the germinal zones of both the neocortex and the cerebellum and in the pontine gray nuclei (PubMed:28453519). Expressed in the neuroepithelium of telencephalon, diencephalon and rhombencephalon at 11 dpc (PubMed:28453519). The DH (DBL-homology) domain promotes tyrosine phosphorylation of RIPK2 (By similarity). The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA. The PH domain has no affinity for phosphoinositides suggesting that it does not interact directly with membranes. The phorbol-ester/DAG-type zinc-finger and the C-terminal coiled-coil domains (606-986) are both important for association with microtubules. Phosphorylation of Ser-885 by PAK1 induces binding to protein YWHAZ, promoting its relocation to microtubules and the inhibition of its activity. Phosphorylated by AURKA and CDK1 during mitosis, which negatively regulates its activity. Phosphorylation by MAPK1 or MAPK3 increases nucleotide exchange activity. Phosphorylation by PAK4 releases GEF-H1 from the microtubules. Phosphorylated on serine, threonine and tyrosine residues in a RIPK2-dependent manner (By similarity). Mice show reduced volume of the total brain, the cerebellum and the brainstem. Show complete lack of precerebellar pontin gray and reticulotegmental nuclei. Show impaired precerebellar neuron migration. Sequence=BAC41438.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; establishment of mitotic spindle orientation cell morphogenesis podosome immune system process guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding cytoplasm Golgi apparatus spindle cytoskeleton microtubule bicellular tight junction actin filament organization negative regulation of microtubule depolymerization cell cycle multicellular organism development nervous system development microtubule binding postsynaptic density Rho GTPase binding cell junction cell differentiation Rac guanyl-nucleotide exchange factor activity cytoplasmic vesicle vesicle ruffle membrane positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production macromolecular complex regulation of Rho protein signal transduction intracellular signal transduction neuronal cell body dendritic shaft innate immune response positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding Rac GTPase binding positive regulation of peptidyl-tyrosine phosphorylation negative regulation of neurogenesis positive regulation of NF-kappaB transcription factor activity cell division asymmetric neuroblast division cellular response to muramyl dipeptide negative regulation of podosome assembly glutamatergic synapse postsynaptic density, intracellular component positive regulation of neuron migration uc008pvy.1 uc008pvy.2 uc008pvy.3 uc008pvy.4 
ENSMUST00000170662.2 Sox21 ENSMUST00000170662.2 SRY (sex determining region Y)-box 21 (from RefSeq NM_177753.3) B9EJU0 ENSMUST00000170662.1 NM_177753 Q811W0 Q8VH35 SOX21_MOUSE uc007uyt.1 uc007uyt.2 uc007uyt.3 uc007uyt.4 uc007uyt.5 May play a role as an activator of transcription of OPRM1 (PubMed:12446692). Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells (PubMed:12446692). May play a role in ameloblast differentiation (PubMed:34812512). Nucleus Highly expressed in both pre-secretory and secretory differentiated ameloblasts in molars at postnatal day 1 (P1). Expression of ameloblastin AMBN is significantly reduced in the tooth germ of postnatal day 1 (P1) molars, but ASCL5/AmeloD expression is not altered. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding hair follicle development DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated cell differentiation hair cycle skin development nuclear transcription factor complex positive regulation of transcription from RNA polymerase II promoter stem cell differentiation uc007uyt.1 uc007uyt.2 uc007uyt.3 uc007uyt.4 uc007uyt.5 
ENSMUST00000170665.3 Teddm3 ENSMUST00000170665.3 transmembrane epididymal family member 3 (from RefSeq NM_025634.3) 2310042E22Rik ENSMUST00000170665.1 ENSMUST00000170665.2 NM_025634 Q9CQH1 Q9CQH1_MOUSE Teddm3 uc007yrf.1 uc007yrf.2 uc007yrf.3 uc007yrf.4 Membrane ; Multi- pass membrane protein Belongs to the TMEM45 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007yrf.1 uc007yrf.2 uc007yrf.3 uc007yrf.4 
ENSMUST00000170672.9 Shisa9 ENSMUST00000170672.9 shisa family member 9, transcript variant 1 (from RefSeq NM_028277.2) D4NZG2 D4NZG3 ENSMUST00000170672.1 ENSMUST00000170672.2 ENSMUST00000170672.3 ENSMUST00000170672.4 ENSMUST00000170672.5 ENSMUST00000170672.6 ENSMUST00000170672.7 ENSMUST00000170672.8 NM_028277 Q9CZN4 SHSA9_MOUSE uc007yfs.1 uc007yfs.2 uc007yfs.3 uc007yfs.4 Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses. Component of some AMPA receptors (ionotropic glutamate receptors) complex, at least composed of some AMPA receptor (GRIA1, GRIA2 and/or GRIA3), CACNG2 and SHISA9, as well as low level of DLG4. Cell projection, dendritic spine membrane ; Single-pass type I membrane protein Synapse Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9CZN4-1; Sequence=Displayed; Name=2; IsoId=Q9CZN4-2; Sequence=VSP_039229, VSP_039230; Name=3; Synonyms=Ckamp44a; IsoId=Q9CZN4-3; Sequence=VSP_039231; Name=4; Synonyms=Ckamp44b; IsoId=Q9CZN4-4; Sequence=VSP_039231, VSP_039232; Brain-specific. Mainly expressed in neurons, including in hippocampus, cerebral cortex, striatum, thalamus, olfactory bulb and cerebellum. Expressed in most brain structures during embryonic and postnatal development. The extracellular domain contains a pattern of cysteine similar to the snail conotoxin Con-ikot-ikot (AC P0CB20), a toxin known to disrupt AMPA receptors (ionotropic glutamate receptor) desensitization. Induces an increase in the paired-pulse ratio of AMPA currents in lateral and medial perforant path-granule cell synapses. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. [Isoform 3]: Produced by aberrant splicing sites. [Isoform 4]: Produced by aberrant splicing sites. Belongs to the shisa family. SHISA9 subfamily. Sequence=BAB28201.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; plasma membrane ionotropic glutamate receptor complex postsynaptic density membrane integral component of membrane cell junction PDZ domain binding AMPA glutamate receptor complex dendritic spine membrane cell projection synapse postsynaptic membrane regulation of short-term neuronal synaptic plasticity postsynaptic density membrane regulation of postsynaptic neurotransmitter receptor activity glutamatergic synapse integral component of postsynaptic density membrane regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc007yfs.1 uc007yfs.2 uc007yfs.3 uc007yfs.4 
ENSMUST00000170686.8 Gm3453 ENSMUST00000170686.8 Gm3453 (from geneSymbol) ENSMUST00000170686.1 ENSMUST00000170686.2 ENSMUST00000170686.3 ENSMUST00000170686.4 ENSMUST00000170686.5 ENSMUST00000170686.6 ENSMUST00000170686.7 Gm3453 K7N724 K7N724_MOUSE uc288qnk.1 uc288qnk.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qnk.1 uc288qnk.2 
ENSMUST00000170693.9 Ube2d2a ENSMUST00000170693.9 ubiquitin-conjugating enzyme E2D 2A (from RefSeq NM_019912.2) ENSMUST00000170693.1 ENSMUST00000170693.2 ENSMUST00000170693.3 ENSMUST00000170693.4 ENSMUST00000170693.5 ENSMUST00000170693.6 ENSMUST00000170693.7 ENSMUST00000170693.8 NM_019912 Q3UT95 Q3UT95_MOUSE Ube2d2a uc012bbj.1 uc012bbj.2 uc012bbj.3 Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence=; Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L- cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.24; Evidence=; Belongs to the ubiquitin-conjugating enzyme family. ubiquitin ligase complex nucleotide binding protein polyubiquitination ubiquitin-protein transferase activity ATP binding protein ubiquitination transferase activity macromolecular complex protein autoubiquitination ubiquitin conjugating enzyme activity protein K48-linked ubiquitination uc012bbj.1 uc012bbj.2 uc012bbj.3 
ENSMUST00000170694.9 Gm2237 ENSMUST00000170694.9 predicted gene 2237, transcript variant 2 (from RefSeq NM_001374120.1) E9Q501 E9Q501_MOUSE ENSMUST00000170694.1 ENSMUST00000170694.2 ENSMUST00000170694.3 ENSMUST00000170694.4 ENSMUST00000170694.5 ENSMUST00000170694.6 ENSMUST00000170694.7 ENSMUST00000170694.8 Gm2237 NM_001374120 uc007shz.1 uc007shz.2 uc007shz.3 uc007shz.4 uc007shz.5 uc007shz.6 uc007shz.7 uc007shz.1 uc007shz.2 uc007shz.3 uc007shz.4 uc007shz.5 uc007shz.6 uc007shz.7 
ENSMUST00000170695.4 Pcdh10 ENSMUST00000170695.4 protocadherin 10, transcript variant 3 (from RefSeq NM_001098171.1) ENSMUST00000170695.1 ENSMUST00000170695.2 ENSMUST00000170695.3 NM_001098171 Pcadh10 Pcdh10 Q925I8 Q925I8_MOUSE uc008pcz.1 uc008pcz.2 uc008pcz.3 calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008pcz.1 uc008pcz.2 uc008pcz.3 
ENSMUST00000170705.8 Gtf2e2 ENSMUST00000170705.8 general transcription factor II E, polypeptide 2 (beta subunit), transcript variant 3 (from RefSeq NM_001167921.1) ENSMUST00000170705.1 ENSMUST00000170705.2 ENSMUST00000170705.3 ENSMUST00000170705.4 ENSMUST00000170705.5 ENSMUST00000170705.6 ENSMUST00000170705.7 NM_001167921 Q3U5Y7 Q8BTZ2 Q8VE14 Q9D902 T2EB_MOUSE uc009lkh.1 uc009lkh.2 uc009lkh.3 uc009lkh.4 Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Tetramer of two alpha and two beta chains. Interacts with FACT subunit SUPT16H. Interacts with ATF7IP. Interacts with SND1. Q9D902; Q7TNS8: Epop; NbExp=2; IntAct=EBI-309435, EBI-16024836; Nucleus Belongs to the TFIIE beta subunit family. DNA binding protein binding nucleus nucleoplasm transcription factor TFIID complex transcription factor TFIIE complex cytosol transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter obsolete general RNA polymerase II transcription factor activity nuclear speck TFIIH-class transcription factor binding uc009lkh.1 uc009lkh.2 uc009lkh.3 uc009lkh.4 
ENSMUST00000170715.8 Rps2 ENSMUST00000170715.8 ribosomal protein S2 (from RefSeq NM_008503.5) ENSMUST00000170715.1 ENSMUST00000170715.2 ENSMUST00000170715.3 ENSMUST00000170715.4 ENSMUST00000170715.5 ENSMUST00000170715.6 ENSMUST00000170715.7 NM_008503 Q58EU3 Q58EU3_MOUSE Rps2 uc008axy.1 uc008axy.2 uc008axy.3 uc008axy.4 Belongs to the universal ribosomal protein uS5 family. ribosomal small subunit assembly formation of translation preinitiation complex RNA binding structural constituent of ribosome ribosome translation small ribosomal subunit cytosolic small ribosomal subunit macromolecular complex binding response to ethanol ribonucleoprotein complex uc008axy.1 uc008axy.2 uc008axy.3 uc008axy.4 
ENSMUST00000170719.2 Sftpa1 ENSMUST00000170719.2 surfactant associated protein A1 (from RefSeq NM_023134.5) ENSMUST00000170719.1 NM_023134 Q9CQI1 Q9CQI1_MOUSE Sftpa1 uc007tcn.1 uc007tcn.2 uc007tcn.3 response to hypoxia extracellular space multivesicular body rough endoplasmic reticulum circadian rhythm response to hormone cytoplasmic vesicle response to lipopolysaccharide response to retinoic acid response to vitamin A positive regulation of phagocytosis response to glucocorticoid response to hyperoxia response to interleukin-6 response to epidermal growth factor cellular response to mechanical stimulus cellular response to nitric oxide uc007tcn.1 uc007tcn.2 uc007tcn.3 
ENSMUST00000170738.3 Gm10406 ENSMUST00000170738.3 predicted gene 10406 (from RefSeq NM_001164727.1) A6NAS4 A6NAS4_MOUSE ENSMUST00000170738.1 ENSMUST00000170738.2 Gm10406 NM_001164727 uc011zfq.1 uc011zfq.2 molecular_function cellular_component biological_process uc011zfq.1 uc011zfq.2 
ENSMUST00000170757.3 C2cd2 ENSMUST00000170757.3 C2 calcium-dependent domain containing 2 (from RefSeq NM_174847.2) C2CD2_MOUSE C2cd2 E9Q3C1 ENSMUST00000170757.1 ENSMUST00000170757.2 Kiaa4045 NM_174847 Q3TE01 Q3UP20 Q5DTR6 Q80XM8 uc008ads.1 uc008ads.2 uc008ads.3 Membrane ; Single-pass membrane protein Sequence=BAD90483.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function biological_process membrane integral component of membrane uc008ads.1 uc008ads.2 uc008ads.3 
ENSMUST00000170759.3 Gpatch11 ENSMUST00000170759.3 G patch domain containing 11, transcript variant 1 (from RefSeq NM_181649.7) A0A0R4J215 A0A0R4J215_MOUSE ENSMUST00000170759.1 ENSMUST00000170759.2 Gpatch11 NM_181649 uc008dpf.1 uc008dpf.2 uc008dpf.3 uc008dpf.4 Belongs to the GPATCH11 family. kinetochore nucleic acid binding uc008dpf.1 uc008dpf.2 uc008dpf.3 uc008dpf.4 
ENSMUST00000170760.3 Siglec15 ENSMUST00000170760.3 sialic acid binding Ig-like lectin 15 (from RefSeq NM_001101038.2) A7E1W8 A7E1W8_MOUSE ENSMUST00000170760.1 ENSMUST00000170760.2 NM_001101038 Siglec15 uc008fsb.1 uc008fsb.2 uc008fsb.3 protein binding plasma membrane membrane integral component of membrane regulation of actin cytoskeleton organization macromolecular complex regulation of bone resorption regulation of osteoclast development uc008fsb.1 uc008fsb.2 uc008fsb.3 
ENSMUST00000170788.9 Schip1 ENSMUST00000170788.9 schwannomin interacting protein 1, transcript variant 4 (from RefSeq NM_013928.5) A8IJC6 A8IJD0 A8IJD3 ENSMUST00000170788.1 ENSMUST00000170788.2 ENSMUST00000170788.3 ENSMUST00000170788.4 ENSMUST00000170788.5 ENSMUST00000170788.6 ENSMUST00000170788.7 ENSMUST00000170788.8 F6YL02 F8WI70 NM_013928 P0DPB4 Q3TI53 Q52KH1 Q6P9Y8 Q9CX07 Q9JLR0 SCHI1_MOUSE Schip1 uc008plt.1 uc008plt.2 uc008plt.3 uc008plt.4 Homooligomer (via coiled coil domain) (By similarity). Interacts with NF2; the interaction is direct (By similarity). Interacts with ANK3 (By similarity). P0DPB4; P35240: NF2; Xeno; NbExp=2; IntAct=EBI-1397475, EBI-1014472; Event=Alternative splicing; Named isoforms=6; Name=Schip1-1; Synonyms=Schip-1a ; IsoId=P0DPB4-1, Q3TI53-5; Sequence=Displayed; Name=Schip1-2; IsoId=P0DPB4-2, Q3TI53-1; Sequence=VSP_046119; Name=Schip1-3; IsoId=P0DPB4-3, Q3TI53-3; Sequence=VSP_025831, VSP_025834; Name=Schip1-4; Synonyms=Schip-1b ; IsoId=P0DPB4-4, Q3TI53-6; Sequence=VSP_046121; Name=Iqcj-schip1-1; Synonyms=IQCJ-SCHIP-1; IsoId=A0A088MLT8-1; Sequence=External; Name=Iqcj-schip1-2; IsoId=A0A088MLT8-2; Sequence=External; Mice lacking all isoforms encoded by both Schip1 and Iqcj-Schip1 are fertile and survive as long as wild-type mice. However, they exhibit mild growth delay associated with ataxia and reduced pain sensitivity. They display decreased thickness of the piriform cortex and partial agenesis of the anterior comissure which could be due to impaired axon elongation and guidance. The morphology of nodes of Ranvier is affected but nerves do not exhibit significant electrophysiological characteristic differences. A reduction in the number of axonal projections in the peripheral nerve system is also observed. Belongs to the SCHIP1 family. Sequence=AAH94348.1; Type=Frameshift; Evidence=; Sequence=AAH94348.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; Sequence=BAB32387.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB32387.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; luteinization kidney development protein binding cytoplasm nitrogen compound metabolic process estrogen metabolic process female gonad development post-embryonic development fibroblast migration identical protein binding protein homodimerization activity platelet-derived growth factor receptor signaling pathway skeletal system morphogenesis smooth muscle tissue development palate development face morphogenesis uc008plt.1 uc008plt.2 uc008plt.3 uc008plt.4 
ENSMUST00000170790.9 Gm10340 ENSMUST00000170790.9 Gm10340 (from geneSymbol) EF651814 ENSMUST00000170790.1 ENSMUST00000170790.2 ENSMUST00000170790.3 ENSMUST00000170790.4 ENSMUST00000170790.5 ENSMUST00000170790.6 ENSMUST00000170790.7 ENSMUST00000170790.8 Gm10128 Gm10340 K7N708 K7N708_MOUSE L7N2B6 uc007sao.1 uc007sao.2 uc007sao.3 uc007sao.4 uc007sao.5 uc007sao.6 molecular_function cellular_component biological_process uc007sao.1 uc007sao.2 uc007sao.3 uc007sao.4 uc007sao.5 uc007sao.6 
ENSMUST00000170794.8 Pkdcc ENSMUST00000170794.8 protein kinase domain containing, cytoplasmic, transcript variant 1 (from RefSeq NM_134117.3) B6F136 ENSMUST00000170794.1 ENSMUST00000170794.2 ENSMUST00000170794.3 ENSMUST00000170794.4 ENSMUST00000170794.5 ENSMUST00000170794.6 ENSMUST00000170794.7 NM_134117 PKDCC_MOUSE Pkdcc Q3UZD3 Q5RJI4 Q8VBZ6 Sgk493 Vlk uc012axu.1 uc012axu.2 uc012axu.3 Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). May also have serine/threonine protein kinase activity (PubMed:25171405). Required for longitudinal bone growth through regulation of chondrocyte differentiation (PubMed:19097194, PubMed:23792766). May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (PubMed:19465597). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10597; Evidence=; Secreted Golgi apparatus Note=Both secreted and present in the Golgi apparatus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5RJI4-1; Sequence=Displayed; Name=2; IsoId=Q5RJI4-2; Sequence=VSP_038822; Strongly expressed in adult heart, liver and testis with weak expression in brain, spleen, lung and thymus. In the humerus, strongly expressed in early flat proliferative chondrocytes. In the embryo, expressed in the anterior visceral endoderm and anterior primitive streak at 6.5 dpc. At 7.5 dpc, expressed in the anterior definitive endoderm (ADE) and anterior mesoderm but not in the notochord. At 8.0 dpc, expressed in the ADE and anterior embryonic mesoderm. At 8.5 dpc, expressed more broadly in anterior tissues and at the midline of the neural plate in the midbrain region as well as the lateral margins of the neural plate posterior to the metencephalic region. Also weakly expressed in the anterior mesenchyme. At 9.5 dpc, strongest expression in branchial arches and limb buds. During mid- gestation, expression continues in mesenchymal cells, particularly in areas where these cells condense. Expressed throughout embryogenesis and in adulthood. During embryogenesis, expression is high at transition phases of mesenchymal cell differentiation such as from mesenchymal cells to chondrocytes and from mesenchymal to mesothelial cells. Expressed throughout all stages of humerus bone formation. During lung development, expressed in all mesenchymal cells at the early pseudoglandular stage. Expression is rapidly lost from the mesenchyme of the lung interstitium during the mid-to-late pseudoglandular stage but continues throughout life in the mesothelial pleural cells. Down-regulated by hedgehog (Hh) signaling. Phosphorylated on tyrosines; probably via autophosphorylation. N-glycosylated. Morphological defects at birth including growth retardation, short limbs, cleft palate, sternal dysraphia, shortened intestine and cyanosis. Long bones display reduced mineralization due to delayed chondrocyte differentiation. Neonates breathe abnormally, do not suckle and die within a day after birth, probably due to insufficient respiration as a result of the cleft palate. Belongs to the protein kinase superfamily. Sequence=AAH86639.1; Type=Frameshift; Evidence=; nucleotide binding skeletal system development ossification protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity ATP binding extracellular region Golgi apparatus protein phosphorylation multicellular organism development protein transport kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation cell differentiation bone mineralization positive regulation of bone mineralization positive regulation of chondrocyte differentiation limb morphogenesis multicellular organism growth negative regulation of Golgi to plasma membrane protein transport lung alveolus development embryonic digestive tract development palate development uc012axu.1 uc012axu.2 uc012axu.3 
ENSMUST00000170795.3 Mcm3ap ENSMUST00000170795.3 minichromosome maintenance complex component 3 associated protein (from RefSeq NM_019434.3) ENSMUST00000170795.1 ENSMUST00000170795.2 GANP_MOUSE Ganp Map80 NM_019434 Q7TS87 Q9WUU9 uc007fup.1 uc007fup.2 uc007fup.3 As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). Reaction=acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L- lysyl-[histone]; Xref=Rhea:RHEA:21992, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:11338, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21993; Evidence=; Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, 2 copies of ENY2, PCID2, SEM1/DSS1, and either centrin CETN2 or centrin CETN3. The TREX-2 complex also associates with ALYREF/ALY (By similarity). Interacts with RNA polymerase II subunit POLR2A and with the transcription elongation factor SUPT5H/SPT5 (By similarity). Interacts (via FG-repeats) with NXF1; this interaction is not mediated by RNA (By similarity). Interacts with nuclear envelope proteins NUP62, NUP153 and RANBP2/NUP358; interaction with NUP153 is required for full localization at the nuclear pore complex (By similarity). Interacts with several RNA helicases, including DHX9, DDX21, and DDX39A/DDX39, and with DNA topoisomerase TOP2A (By similarity). Directly interacts with AICDA/AID (PubMed:20507984). Interacts with the glucocorticoid receptor NR3C1 (By similarity). Interacts with MCM3 (PubMed:10733502). Cytoplasm cleus cleus envelope Nucleus, nuclear pore complex Nucleus, nucleoplasm Chromosome Note=In stimulated B-cells, selectively targeted to immunoglobulin gene variable regions (PubMed:20507984). Predominantly located at the nuclear envelope, facing the nucleus interior (By similarity). Localization at the nuclear pore complex requires NUP153, TPR and ALYREF/ALY (By similarity). Also found associated with chromatin (PubMed:23652018). In B-cells, targeted to the immunoglobulin variable region genes (PubMed:20507984, PubMed:23652018). Expressed at low levels in lymphoid organs, including thymus, spleen and lymph nodes (PubMed:10733502). Up- regulated in stimulated B-cells in spleen and Peyer's patch germinal centers (at protein level) (PubMed:11526238). Up-regulated in B-cells by CD40 stimulation and bacterial lipopolysaccharide (LPS) (at protein level). Phosphorylation at Ser-502 is induced in B-cells by CD40- stimulation, but not by bacterial lipopolysaccharide (LPS). Embryonic lethal at 11.5 dpc. Belongs to the SAC3 family. immune system process nucleic acid binding chromatin binding histone acetyltransferase activity nucleus nuclear envelope nuclear pore nucleoplasm chromosome cytoplasm cytosol mRNA export from nucleus H3 histone acetyltransferase activity protein transport somatic hypermutation of immunoglobulin genes histone acetylation transferase activity transferase activity, transferring acyl groups poly(A)+ mRNA export from nucleus nuclear membrane nucleosome organization histone binding histone H3 acetylation nuclear pore nuclear basket mRNA transport transcription export complex 2 uc007fup.1 uc007fup.2 uc007fup.3 
ENSMUST00000170808.3 Vmn2r22 ENSMUST00000170808.3 vomeronasal 2, receptor 22 (from RefSeq NM_001104637.1) E9PYE6 E9Q7S8 E9Q7S8_MOUSE ENSMUST00000170808.1 ENSMUST00000170808.2 NM_001104637 Vmn2r20 Vmn2r21 Vmn2r22 uc009vdx.1 uc009vdx.2 uc009vdx.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vdx.1 uc009vdx.2 uc009vdx.3 
ENSMUST00000170816.3 Gm3625 ENSMUST00000170816.3 Gm3625 (from geneSymbol) ENSMUST00000170816.1 ENSMUST00000170816.2 uc288eqy.1 uc288eqy.2 uc288eqy.3 uc288eqy.1 uc288eqy.2 uc288eqy.3 
ENSMUST00000170817.2 Slc22a8 ENSMUST00000170817.2 solute carrier family 22 (organic anion transporter), member 8, transcript variant 7 (from RefSeq NM_001411473.1) ENSMUST00000170817.1 NM_001411473 O88909 Oat3 Q3TZF9 Q8CCX3 Q8CFH5 Q91WJ9 Roct S22A8_MOUSE uc012bia.1 uc012bia.2 uc012bia.3 Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient (By similarity). Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (PubMed:17220594). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain (PubMed:12011098, PubMed:15075193, PubMed:17220594, PubMed:21325432). E1S transport is pH- and chloride-dependent and may also involve E1S/cGMP exchange. Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule. Involved in the transport of neuroactive tryptophan metabolites kynurenate and xanthurenate. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (By similarity). May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside (By similarity). May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (By similarity). May contribute to the release of cortisol in the adrenals (By similarity). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (PubMed:12011098). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic drugs allopurinol, 6-mercaptopurine (6-MP) and 5-fluorouracil (5-FU) (PubMed:15100168, PubMed:17220594). Mediates the transport of PAH, PCG, and the statins pravastatin and pitavastatin, from the cerebrum into the blood circulation across the blood-brain barrier (BBB) (By similarity). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS), indole acetate (IA), hippurate/N-benzoylglycine (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin- converting enzyme (ACE) inhibitor) (By similarity). In summary, plays a role in the efflux of drugs and xenobiotics, helping reduce their undesired toxicological effects on the body (By similarity). Reaction=estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out); Xref=Rhea:RHEA:72151, ChEBI:CHEBI:30921, ChEBI:CHEBI:60050; Evidence= Reaction=2-oxoglutarate(out) + estrone 3-sulfate(in) = 2- oxoglutarate(in) + estrone 3-sulfate(out); Xref=Rhea:RHEA:72399, ChEBI:CHEBI:16810, ChEBI:CHEBI:60050; Evidence=; Reaction=glutarate(in) + taurocholate(out) = glutarate(out) + taurocholate(in); Xref=Rhea:RHEA:72159, ChEBI:CHEBI:30921, ChEBI:CHEBI:36257; Evidence=; Reaction=dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out); Xref=Rhea:RHEA:72355, ChEBI:CHEBI:30921, ChEBI:CHEBI:57905; Evidence=; Reaction=2-oxoglutarate(out) + glutarate(in) = 2-oxoglutarate(in) + glutarate(out); Xref=Rhea:RHEA:71751, ChEBI:CHEBI:16810, ChEBI:CHEBI:30921; Evidence=; Reaction=2-oxoglutarate(out) + urate(in) = 2-oxoglutarate(in) + urate(out); Xref=Rhea:RHEA:72403, ChEBI:CHEBI:16810, ChEBI:CHEBI:17775; Evidence=; Reaction=glutarate(in) + prostaglandin F2alpha(out) = glutarate(out) + prostaglandin F2alpha(in); Xref=Rhea:RHEA:72503, ChEBI:CHEBI:30921, ChEBI:CHEBI:57404; Evidence=; Reaction=2-oxoglutarate(in) + prostaglandin F2alpha(out) = 2- oxoglutarate(out) + prostaglandin F2alpha(in); Xref=Rhea:RHEA:72507, ChEBI:CHEBI:16810, ChEBI:CHEBI:57404; Evidence=; Reaction=(R)-carnitine(out) + 2-oxoglutarate(in) = (R)-carnitine(in) + 2-oxoglutarate(out); Xref=Rhea:RHEA:72511, ChEBI:CHEBI:16347, ChEBI:CHEBI:16810; Evidence=; Reaction=(R)-carnitine(out) + glutarate(in) = (R)-carnitine(in) + glutarate(out); Xref=Rhea:RHEA:72515, ChEBI:CHEBI:16347, ChEBI:CHEBI:30921; Evidence=; Reaction=2-oxoglutarate(in) + prostaglandin E2(out) = 2- oxoglutarate(out) + prostaglandin E2(in); Xref=Rhea:RHEA:72499, ChEBI:CHEBI:16810, ChEBI:CHEBI:606564; Evidence=; Reaction=glutarate(in) + prostaglandin E2(out) = glutarate(out) + prostaglandin E2(in); Xref=Rhea:RHEA:72495, ChEBI:CHEBI:30921, ChEBI:CHEBI:606564; Evidence=; Reaction=glutarate(out) + urate(in) = glutarate(in) + urate(out); Xref=Rhea:RHEA:72551, ChEBI:CHEBI:17775, ChEBI:CHEBI:30921; Evidence=; Reaction=2-oxoglutarate(in) + taurocholate(out) = 2-oxoglutarate(out) + taurocholate(in); Xref=Rhea:RHEA:72547, ChEBI:CHEBI:16810, ChEBI:CHEBI:36257; Evidence=; Reaction=2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) = 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in); Xref=Rhea:RHEA:72543, ChEBI:CHEBI:16810, ChEBI:CHEBI:57905; Evidence=; Reaction=a dicarboxylate(in) + kynurenate(out) = a dicarboxylate(out) + kynurenate(in); Xref=Rhea:RHEA:76087, ChEBI:CHEBI:28965, ChEBI:CHEBI:58454; Evidence=; Reaction=(indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3- yl)acetate(in) + a dicarboxylate(out); Xref=Rhea:RHEA:75983, ChEBI:CHEBI:28965, ChEBI:CHEBI:30854; Evidence=; Reaction=a dicarboxylate(in) + indoxyl sulfate(out) = a dicarboxylate(out) + indoxyl sulfate(in); Xref=Rhea:RHEA:75987, ChEBI:CHEBI:28965, ChEBI:CHEBI:144643; Evidence=; Reaction=a dicarboxylate(in) + N-benzoylglycine(out) = a dicarboxylate(out) + N-benzoylglycine(in); Xref=Rhea:RHEA:75991, ChEBI:CHEBI:28965, ChEBI:CHEBI:606565; Evidence=; Reaction=3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out); Xref=Rhea:RHEA:75995, ChEBI:CHEBI:28965, ChEBI:CHEBI:194524; Evidence=; Reaction=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out); Xref=Rhea:RHEA:76071, ChEBI:CHEBI:28965, ChEBI:CHEBI:59560; Evidence=; Reaction=a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out) = a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in); Xref=Rhea:RHEA:76075, ChEBI:CHEBI:28965, ChEBI:CHEBI:43029; Evidence=; Reaction=a dicarboxylate(in) + L-sepiapterin(out) = a dicarboxylate(out) + L-sepiapterin(in); Xref=Rhea:RHEA:76079, ChEBI:CHEBI:28965, ChEBI:CHEBI:194527; Evidence=; Expression inhibited by androgens such as testosterone. Kinetic parameters: KM=61.9 nM for L-carnitine ; KM=4.01 uM for 6-mercaptopurine ; KM=53.9 nM for 5-fluorouracil ; KM=1.48 uM for prostaglandin E(2) ; Basolateral cell membrane ulti-pass membrane protein Note=Localized to the basolateral side of all renal epithelia except the glomerulus (PubMed:15944205). Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). Expressed mainly in kidney (PubMed:12011098, PubMed:15100168, PubMed:10087192, PubMed:23389457). In kidney, detected in almost all parts of the nephron, including macula densa cells (PubMed:15944205). Expressed (at protein level) throughout the renal cortex (PubMed:17220594). Widely distributed in the brain with no large regional differences (PubMed:21325432). Expressed in the choroid plexus (CP, located in the ventricles of the brain) (PubMed:12011098). Expressed in developing bone (PubMed:10087192). Weakly expressed in brain and eye (PubMed:15100168). Mice appear healthy and are fertile. Exhibit a loss of taurocholate, estrone sulfate and para-aminohippurate transport in kidney and of fluorescein (FL) transport in choroid plexus. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. protein kinase C binding inorganic anion exchanger activity plasma membrane ion transport organic anion transmembrane transporter activity response to toxic substance quaternary ammonium group transmembrane transporter activity quaternary ammonium group transport inorganic anion transport membrane integral component of membrane basolateral plasma membrane transmembrane transporter activity glutathione transport transmembrane transport uc012bia.1 uc012bia.2 uc012bia.3 
ENSMUST00000170819.2 Rab11fip2 ENSMUST00000170819.2 A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. (from UniProt G3XA57) B9EID4 BC139380 ENSMUST00000170819.1 G3XA57 Q5HZI0 RFIP2_MOUSE uc289snv.1 uc289snv.2 A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. Homooligomerizes in a Rab11-independent manner. Forms a heterooligomeric complex with RAB11FIP4. Interacts with AP2A1, MYO5B, RAB25 and REPS1. Interacts with RAB11A and RAB11B (activated GTP-bound form). Interacts with NPC1L1. Interacts (via NPF motifs) with EHD1 and EHD3. Interacts with TICAM2; this interaction directs RAB11FIP2 to the phagosome. Cell membrane; Peripheral membrane protein. Recycling endosome membrane ; Peripheral membrane protein Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=G3XA57-1; Sequence=Displayed; Name=2; IsoId=G3XA57-2; Sequence=VSP_053310; Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity. phagocytic cup nucleoplasm endosome plasma membrane phagocytosis protein transport membrane Rab GTPase binding protein kinase binding establishment of cell polarity TRAM-dependent toll-like receptor 4 signaling pathway insulin secretion involved in cellular response to glucose stimulus identical protein binding protein homodimerization activity intracellular membrane-bounded organelle positive regulation of GTPase activity regulated exocytosis recycling endosome membrane positive regulation of protein localization to plasma membrane uc289snv.1 uc289snv.2 
ENSMUST00000170832.3 Prol1 ENSMUST00000170832.3 proline rich, lacrimal 1 (from RefSeq NM_008644.2) E9PYQ4 E9PYQ4_MOUSE ENSMUST00000170832.1 ENSMUST00000170832.2 NM_008644 Prol1 uc012dya.1 uc012dya.2 uc012dya.3 protein binding plasma membrane membrane uc012dya.1 uc012dya.2 uc012dya.3 
ENSMUST00000170835.4 Vmn2r78 ENSMUST00000170835.4 vomeronasal 2, receptor 78 (from RefSeq NM_001105189.1) ENSMUST00000170835.1 ENSMUST00000170835.2 ENSMUST00000170835.3 K7N6U5 K7N6U5_MOUSE NM_001105189 Vmn2r78 uc012for.1 uc012for.2 uc012for.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012for.1 uc012for.2 uc012for.3 
ENSMUST00000170836.4 Psma2 ENSMUST00000170836.4 proteasome subunit alpha 2 (from RefSeq NM_008944.2) E9Q3A4 ENSMUST00000170836.1 ENSMUST00000170836.2 ENSMUST00000170836.3 Lmpc3 NM_008944 P49722 PSA2_MOUSE Q6ZWV8 uc007pnl.1 uc007pnl.2 uc007pnl.3 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Cytoplasm Nucleus Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (By similarity). Colocalizes with TRIM5 in cytoplasmic bodies (PubMed:22078707). Detected in liver (at protein level). Phosphorylated on tyrosine residues; which may be important for nuclear import. Belongs to the peptidase T1A family. proteasome complex P-body endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteolysis ubiquitin-dependent protein catabolic process peptidase activity proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process hydrolase activity proteasome core complex, alpha-subunit complex proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process uc007pnl.1 uc007pnl.2 uc007pnl.3 
ENSMUST00000170837.3 Tmsb10b ENSMUST00000170837.3 Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). (from UniProt Q6ZWY8) AB347444 ENSMUST00000170837.1 ENSMUST00000170837.2 Ptmb10 Q3V2M3 Q6ZWY8 TYB10_MOUSE Tmsb10 uc291mwc.1 uc291mwc.2 Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). Cytoplasm, cytoskeleton Belongs to the thymosin beta family. actin binding actin monomer binding cytoplasm cytoskeleton actin filament organization actin cytoskeleton organization regulation of cell migration sequestering of actin monomers uc291mwc.1 uc291mwc.2 
ENSMUST00000170841.9 Lmntd2 ENSMUST00000170841.9 lamin tail domain containing 2, transcript variant 1 (from RefSeq NM_001347565.1) 1600016N20Rik B7ZMW1 B7ZMW1_MOUSE ENSMUST00000170841.1 ENSMUST00000170841.2 ENSMUST00000170841.3 ENSMUST00000170841.4 ENSMUST00000170841.5 ENSMUST00000170841.6 ENSMUST00000170841.7 ENSMUST00000170841.8 Lmntd2 NM_001347565 uc012fwr.1 uc012fwr.2 uc012fwr.1 uc012fwr.2 
ENSMUST00000170853.8 Synj1 ENSMUST00000170853.8 synaptojanin 1, transcript variant 18 (from RefSeq NM_001405408.1) E9Q7S0 E9Q7S0_MOUSE ENSMUST00000170853.1 ENSMUST00000170853.2 ENSMUST00000170853.3 ENSMUST00000170853.4 ENSMUST00000170853.5 ENSMUST00000170853.6 ENSMUST00000170853.7 NM_001405408 Synj1 uc007zww.1 uc007zww.2 uc007zww.3 uc007zww.4 Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol 4-phosphate) + phosphate; Xref=Rhea:RHEA:22764, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58178, ChEBI:CHEBI:58456; EC=3.1.3.36; Evidence=; Belongs to the synaptojanin family. In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. nucleic acid binding RNA binding hydrolase activity phosphatidylinositol phosphate 5-phosphatase activity phosphoric ester hydrolase activity phosphatidylinositol dephosphorylation synaptic vesicle endocytosis presynapse uc007zww.1 uc007zww.2 uc007zww.3 uc007zww.4 
ENSMUST00000170872.3 Thbs2 ENSMUST00000170872.3 thrombospondin 2 (from RefSeq NM_011581.3) ENSMUST00000170872.1 ENSMUST00000170872.2 NM_011581 Q03350 Q8CG21 TSP2_MOUSE Tsp2 uc008anb.1 uc008anb.2 uc008anb.3 uc008anb.4 Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Ligand for CD36 mediating antiangiogenic properties. Homotrimer; disulfide-linked. Can bind to fibrinogen, fibronectin, laminin and type V collagen (By similarity). Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36. Can bind to fibrinogen, fibronectin, laminin. Q03350; Q63722: Jag1; Xeno; NbExp=2; IntAct=EBI-4567830, EBI-4567800; Q03350; Q07954: LRP1; Xeno; NbExp=2; IntAct=EBI-4567830, EBI-1046087; Belongs to the thrombospondin family. calcium ion binding protein binding extracellular region basement membrane extracellular space cell adhesion heparin binding negative regulation of angiogenesis extracellular matrix platelet alpha granule positive regulation of synapse assembly uc008anb.1 uc008anb.2 uc008anb.3 uc008anb.4 
ENSMUST00000170883.8 Hdlbp ENSMUST00000170883.8 high density lipoprotein (HDL) binding protein, transcript variant 1 (from RefSeq NM_133808.5) ENSMUST00000170883.1 ENSMUST00000170883.2 ENSMUST00000170883.3 ENSMUST00000170883.4 ENSMUST00000170883.5 ENSMUST00000170883.6 ENSMUST00000170883.7 NM_133808 Q8VDJ3 VIGLN_MOUSE uc007cdy.1 uc007cdy.2 uc007cdy.3 uc007cdy.4 Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol (By similarity). Cytoplasm Nucleus nucleic acid binding RNA binding nucleus cytoplasm cytosol lipid metabolic process lipid transport steroid metabolic process cholesterol metabolic process high-density lipoprotein particle uc007cdy.1 uc007cdy.2 uc007cdy.3 uc007cdy.4 
ENSMUST00000170898.2 ENSMUSG00000121728 ENSMUST00000170898.2 ENSMUSG00000121728 (from geneSymbol) ENSMUST00000170898.1 uc292ayi.1 uc292ayi.2 uc292ayi.1 uc292ayi.2 
ENSMUST00000170901.8 Ccne2 ENSMUST00000170901.8 cyclin E2, transcript variant 1 (from RefSeq NM_001037134.3) CCNE2_MOUSE ENSMUST00000170901.1 ENSMUST00000170901.2 ENSMUST00000170901.3 ENSMUST00000170901.4 ENSMUST00000170901.5 ENSMUST00000170901.6 ENSMUST00000170901.7 NM_001037134 Q9QWU5 Q9Z238 uc008rzd.1 uc008rzd.2 uc008rzd.3 uc008rzd.4 Essential for the control of the cell cycle at the late G1 and early S phase. Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (By similarity). Nucleus Highest levels in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway. Belongs to the cyclin family. Cyclin E subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity G1/S transition of mitotic cell cycle cyclin-dependent protein kinase holoenzyme complex telomere maintenance nucleus cytoplasm centrosome DNA replication initiation protein phosphorylation cell cycle synapsis cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding mitotic cell cycle phase transition cell division regulation of cell cycle chromosome organization involved in meiotic cell cycle cyclin E1-CDK2 complex cyclin E2-CDK2 complex regulation of cellular protein localization protein kinase activity uc008rzd.1 uc008rzd.2 uc008rzd.3 uc008rzd.4 
ENSMUST00000170908.8 Dtwd1 ENSMUST00000170908.8 DTW domain containing 1, transcript variant 2 (from RefSeq NM_026981.2) DTWD1_MOUSE Dtwd1 ENSMUST00000170908.1 ENSMUST00000170908.2 ENSMUST00000170908.3 ENSMUST00000170908.4 ENSMUST00000170908.5 ENSMUST00000170908.6 ENSMUST00000170908.7 NM_026981 Q9D8U7 uc008mdk.1 uc008mdk.2 uc008mdk.3 uc008mdk.4 Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)). Reaction=a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3- amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'- thioadenosine; Xref=Rhea:RHEA:62432, Rhea:RHEA-COMP:13339, Rhea:RHEA- COMP:16092, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789, ChEBI:CHEBI:65315, ChEBI:CHEBI:82930; EC=2.5.1.25; Evidence=; Nucleus Belongs to the TDD superfamily. DTWD1 family. molecular_function cellular_component biological_process uc008mdk.1 uc008mdk.2 uc008mdk.3 uc008mdk.4 
ENSMUST00000170922.2 Vmn2r29 ENSMUST00000170922.2 vomeronasal 2, receptor 29, transcript variant 1 (from RefSeq NM_001113468.1) ENSMUST00000170922.1 L7N2D4 L7N2D4_MOUSE NM_001113468 Vmn2r29 uc012exq.1 uc012exq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012exq.1 uc012exq.2 
ENSMUST00000170923.9 Gm21103 ENSMUST00000170923.9 Gm21103 (from geneSymbol) E9Q2Q1 E9Q2Q1_MOUSE ENSMUST00000170923.1 ENSMUST00000170923.2 ENSMUST00000170923.3 ENSMUST00000170923.4 ENSMUST00000170923.5 ENSMUST00000170923.6 ENSMUST00000170923.7 ENSMUST00000170923.8 Gm21103 Gm3597 uc288qoe.1 uc288qoe.2 membrane integral component of membrane uc288qoe.1 uc288qoe.2 
ENSMUST00000170926.8 Lmo2 ENSMUST00000170926.8 LIM domain only 2, transcript variant 9 (from RefSeq NM_001420379.1) ENSMUST00000170926.1 ENSMUST00000170926.2 ENSMUST00000170926.3 ENSMUST00000170926.4 ENSMUST00000170926.5 ENSMUST00000170926.6 ENSMUST00000170926.7 Lmo2 NM_001420379 Q544Z2 Q544Z2_MOUSE uc012caj.1 uc012caj.2 Nucleus metal ion binding uc012caj.1 uc012caj.2 
ENSMUST00000170928.8 Med7 ENSMUST00000170928.8 mediator complex subunit 7, transcript variant 4 (from RefSeq NM_001104557.1) Crsp9 ENSMUST00000170928.1 ENSMUST00000170928.2 ENSMUST00000170928.3 ENSMUST00000170928.4 ENSMUST00000170928.5 ENSMUST00000170928.6 ENSMUST00000170928.7 MED7_MOUSE NM_001104557 Q3UGV1 Q91VN3 Q9CWV8 Q9CZB6 Q9D0V9 uc007iol.1 uc007iol.2 uc007iol.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Nucleus Belongs to the Mediator complex subunit 7 family. ubiquitin ligase complex transcription cofactor activity nucleus nucleoplasm transcription factor complex regulation of transcription from RNA polymerase II promoter protein ubiquitination mediator complex nuclear body stem cell population maintenance ubiquitin protein ligase activity uc007iol.1 uc007iol.2 uc007iol.3 
ENSMUST00000170931.2 Vmn1r135 ENSMUST00000170931.2 vomeronasal 1 receptor 135 (from RefSeq NM_001166747.1) ENSMUST00000170931.1 K9J7G0 K9J7G0_MOUSE NM_001166747 Vmn1r135 Vmn1r163 uc012fdk.1 uc012fdk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fdk.1 uc012fdk.2 
ENSMUST00000170933.2 Gm17354 ENSMUST00000170933.2 Gm17354 (from geneSymbol) ENSMUST00000170933.1 uc290oop.1 uc290oop.2 uc290oop.1 uc290oop.2 
ENSMUST00000170941.3 Treml2 ENSMUST00000170941.3 triggering receptor expressed on myeloid cells-like 2, transcript variant 2 (from RefSeq NM_001360121.1) A0A3F2YNQ7 A0A3F2YNQ7_MOUSE ENSMUST00000170941.1 ENSMUST00000170941.2 NM_001360121 Treml2 uc012avc.1 uc012avc.2 uc012avc.3 membrane integral component of membrane uc012avc.1 uc012avc.2 uc012avc.3 
ENSMUST00000170945.2 Skint3 ENSMUST00000170945.2 selection and upkeep of intraepithelial T cells 3, transcript variant 3 (from RefSeq NM_001348354.1) A7TZF0 A7TZF2 ENSMUST00000170945.1 NM_001348354 Q8BIN0 SKIT3_MOUSE uc008udt.1 uc008udt.2 May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=A7TZF0-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=A7TZF0-2; Sequence=VSP_034881; Name=3; Synonyms=C; IsoId=A7TZF0-3; Sequence=VSP_034880; Expressed in skin and thymus. Encoded by one of the 11 copies of Skint genes clustered in the D1 region of the chromosome 4. Belongs to the SKINT family. receptor binding external side of plasma membrane membrane integral component of membrane regulation of immune response T cell receptor signaling pathway uc008udt.1 uc008udt.2 
ENSMUST00000170947.3 Hoatz ENSMUST00000170947.3 HOATZ cilia and flagella associated protein (from RefSeq NM_177702.4) ENSMUST00000170947.1 ENSMUST00000170947.2 HOATZ_MOUSE Hoatz Hoatzin NM_177702 Q3V0W8 Q80Y73 uc009plc.1 uc009plc.2 uc009plc.3 Required for motile ciliogenesis and flagellar genesis by mediating the maturation of the glycolytic enzyme ENO4. Cytoplasm Cell projection, cilium Specifically expressed in tissues with motile cilia and flagella, such as brain ependyma, lung, testis, and oviduct but not in whole brain, liver,kidney, spleen, and eyeball. Detected as early as postnatal day 15 (P15), and then continually increased during the first 45 days. Male mice exhibit severe defects in spermatogenesis, leading to infertility and varying degrees of hydrocephalus. The epididymal ependymal cilia frequently show disorganized axonemes, reducing motility. Mutant testis shown lack of fully developed flagella in the lumen of the seminiferous tubules; the mutant spermatids elongate but do not maintain the axoneme, leading to severe destruction of the flagella. In contrast, the ultrastructures of motile cilia in the tracheal epithelia are intact. The deficient mice do not display laterality defects, polydactyly, polycystic kidney, or other notable abdominal organ abnormalities indicating that the nodal and primary cilia were unaffected. Named Hoatz according to the Hydrocephalus and Oligo- Astheno-Terato-Zoospermia phenotype of Hoatz knockout mice. Belongs to the HOATZ family. molecular_function cellular_component biological_process uc009plc.1 uc009plc.2 uc009plc.3 
ENSMUST00000170953.3 Rps13 ENSMUST00000170953.3 ribosomal protein S13 (from RefSeq NM_026533.3) ENSMUST00000170953.1 ENSMUST00000170953.2 NM_026533 Q5BLJ7 Q5BLJ7_MOUSE Rps13 uc009jje.1 uc009jje.2 uc009jje.3 uc009jje.4 Belongs to the universal ribosomal protein uS15 family. mRNA binding structural constituent of ribosome nucleus nucleolus ribosome translation postsynaptic density cytosolic small ribosomal subunit negative regulation of RNA splicing mRNA 5'-UTR binding uc009jje.1 uc009jje.2 uc009jje.3 uc009jje.4 
ENSMUST00000170957.3 Ggps1 ENSMUST00000170957.3 geranylgeranyl diphosphate synthase 1, transcript variant 5 (from RefSeq NM_010282.3) ENSMUST00000170957.1 ENSMUST00000170957.2 GGPPS_MOUSE Ggps1 NM_010282 Q9WTN0 uc007pmw.1 uc007pmw.2 uc007pmw.3 uc007pmw.4 Catalyzes the trans-addition of the three molecules of isopentenyl diphosphate (IPP) onto dimethylallyl pyrophosphate (DMAPP) to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Reaction=dimethylallyl diphosphate + isopentenyl diphosphate = (2E)- geranyl diphosphate + diphosphate; Xref=Rhea:RHEA:22408, ChEBI:CHEBI:33019, ChEBI:CHEBI:57623, ChEBI:CHEBI:58057, ChEBI:CHEBI:128769; EC=2.5.1.1; Reaction=(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)- farnesyl diphosphate + diphosphate; Xref=Rhea:RHEA:19361, ChEBI:CHEBI:33019, ChEBI:CHEBI:58057, ChEBI:CHEBI:128769, ChEBI:CHEBI:175763; EC=2.5.1.10; Reaction=(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate; Xref=Rhea:RHEA:17653, ChEBI:CHEBI:33019, ChEBI:CHEBI:58756, ChEBI:CHEBI:128769, ChEBI:CHEBI:175763; EC=2.5.1.29; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17654; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 Mg(2+) ions per subunit. ; Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1. Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1. Homohexamer; trimer of homodimers. Cytoplasm Cytoplasm, perinuclear region Cytoplasm, myofibril, sarcomere, Z line Belongs to the FPP/GGPP synthase family. dimethylallyltranstransferase activity farnesyltranstransferase activity geranyltranstransferase activity cytoplasm isoprenoid metabolic process isoprenoid biosynthetic process transferase activity geranyl diphosphate biosynthetic process geranylgeranyl diphosphate biosynthetic process identical protein binding farnesyl diphosphate biosynthetic process metal ion binding uc007pmw.1 uc007pmw.2 uc007pmw.3 uc007pmw.4 
ENSMUST00000170988.2 Cyp39a1 ENSMUST00000170988.2 cytochrome P450, family 39, subfamily a, polypeptide 1, transcript variant 1 (from RefSeq NM_018887.4) CP39A_MOUSE ENSMUST00000170988.1 NM_018887 Q9JKJ9 uc008cpn.1 uc008cpn.2 uc008cpn.3 uc008cpn.4 A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver (PubMed:10748047). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase) (PubMed:10748047). Reaction=(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46124, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:34310, ChEBI:CHEBI:37640, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.26; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Steroid metabolism; cholesterol degradation. Lipid metabolism; bile acid biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Microsome membrane ; Multi-pass membrane protein Liver specific. Hepatic expression is sexually dimorphic (female > male). Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process bile acid biosynthetic process cholesterol catabolic process digestion steroid metabolic process steroid 7-alpha-hydroxylase activity oxysterol 7-alpha-hydroxylase activity membrane lipid catabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding bile acid catabolic process organelle membrane cholesterol homeostasis intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc008cpn.1 uc008cpn.2 uc008cpn.3 uc008cpn.4 
ENSMUST00000170998.9 Scn2b ENSMUST00000170998.9 sodium channel, voltage-gated, type II, beta (from RefSeq NM_001014761.2) ENSMUST00000170998.1 ENSMUST00000170998.2 ENSMUST00000170998.3 ENSMUST00000170998.4 ENSMUST00000170998.5 ENSMUST00000170998.6 ENSMUST00000170998.7 ENSMUST00000170998.8 Gm183 NM_001014761 Q56A07 SCN2B_MOUSE uc009pfg.1 uc009pfg.2 uc009pfg.3 Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). The voltage-sensitive sodium channel consists of an ion- conducting pore-forming alpha subunit (such as SCN2A or SCN8A) regulated by one or more beta subunits (SCN1B, SCN2B, SCN3B and SCN4B). SCN1B and SCN3B are non-covalently associated with the alpha subunit. SCN2B and SCN4B are disulfide-linked to the alpha subunit (By similarity). Membrane ; Single-pass type I membrane protein Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family. voltage-gated sodium channel complex voltage-gated ion channel activity voltage-gated sodium channel activity sodium channel activity ion transport sodium ion transport nervous system development membrane integral component of membrane sodium channel regulator activity regulation of ion transmembrane transport sodium ion transmembrane transport response to pyrethroid cardiac muscle contraction regulation of atrial cardiac muscle cell membrane depolarization cardiac muscle cell action potential involved in contraction voltage-gated sodium channel activity involved in cardiac muscle cell action potential membrane depolarization during cardiac muscle cell action potential regulation of heart rate by cardiac conduction regulation of sodium ion transmembrane transporter activity uc009pfg.1 uc009pfg.2 uc009pfg.3 
ENSMUST00000171007.2 D630036H23Rik ENSMUST00000171007.2 D630036H23Rik (from geneSymbol) AK142563 ENSMUST00000171007.1 uc288fyv.1 uc288fyv.2 uc288fyv.1 uc288fyv.2 
ENSMUST00000171031.8 Ccnd3 ENSMUST00000171031.8 cyclin D3, transcript variant 3 (from RefSeq NM_001081636.1) Ccnd3 ENSMUST00000171031.1 ENSMUST00000171031.2 ENSMUST00000171031.3 ENSMUST00000171031.4 ENSMUST00000171031.5 ENSMUST00000171031.6 ENSMUST00000171031.7 NM_001081636 Q3TSW4 Q3TSW4_MOUSE uc008cvk.1 uc008cvk.2 uc008cvk.3 uc008cvk.4 Belongs to the cyclin family. cyclin-dependent protein kinase holoenzyme complex positive regulation of protein phosphorylation nucleus protein kinase binding positive regulation of cyclin-dependent protein serine/threonine kinase activity uc008cvk.1 uc008cvk.2 uc008cvk.3 uc008cvk.4 
ENSMUST00000171052.8 Ccdc24 ENSMUST00000171052.8 Ccdc24 (from geneSymbol) BC086615 Ccdc24 E9PUW8 E9PUW8_MOUSE ENSMUST00000171052.1 ENSMUST00000171052.2 ENSMUST00000171052.3 ENSMUST00000171052.4 ENSMUST00000171052.5 ENSMUST00000171052.6 ENSMUST00000171052.7 uc290pfd.1 uc290pfd.2 blastocyst hatching molecular_function cellular_component uc290pfd.1 uc290pfd.2 
ENSMUST00000171093.8 Speer1e ENSMUST00000171093.8 spermatogenesis associated glutamate (E)-rich protein 1E (from RefSeq NM_001310021.1) ENSMUST00000171093.1 ENSMUST00000171093.2 ENSMUST00000171093.3 ENSMUST00000171093.4 ENSMUST00000171093.5 ENSMUST00000171093.6 ENSMUST00000171093.7 F6VCN9 F6VCN9_MOUSE Gm5861 NM_001310021 uc290tdd.1 uc290tdd.2 molecular_function cellular_component biological_process uc290tdd.1 uc290tdd.2 
ENSMUST00000171107.3 Gm9376 ENSMUST00000171107.3 predicted gene 9376 (from RefSeq NM_001101609.1) ENSMUST00000171107.1 ENSMUST00000171107.2 G3UW68 G3UW68_MOUSE Gm9376 NM_001101609 uc011zpy.1 uc011zpy.2 uc011zpy.3 uc011zpy.4 Nucleus Belongs to the paired homeobox family. DNA binding cellular_component nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding uc011zpy.1 uc011zpy.2 uc011zpy.3 uc011zpy.4 
ENSMUST00000171127.4 H2ac6 ENSMUST00000171127.4 H2A clustered histone 6 (from RefSeq NM_178189.5) C0HKE9 ENSMUST00000171127.1 ENSMUST00000171127.2 ENSMUST00000171127.3 H2A1P_MOUSE Hist1h2ap NM_178189 P10812 P22752 Q149U0 Q5SZZ2 uc007puk.1 uc007puk.2 uc007puk.3 uc007puk.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'- linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc007puk.1 uc007puk.2 uc007puk.3 uc007puk.4 
ENSMUST00000171139.3 H2-M2 ENSMUST00000171139.3 histocompatibility 2, M region locus 2 (from RefSeq NM_001347387.1) ENSMUST00000171139.1 ENSMUST00000171139.2 H2-M2 NM_001347387 Q6W9L1 Q6W9L1_MOUSE uc008cna.1 uc008cna.2 uc008cna.3 Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane cell surface membrane integral component of membrane peptide antigen binding uc008cna.1 uc008cna.2 uc008cna.3 
ENSMUST00000171143.2 Eeig2 ENSMUST00000171143.2 EEIG family member 2 (from RefSeq NM_001163567.1) E9Q4R1 E9Q4R1_MOUSE ENSMUST00000171143.1 Eeig2 Fam102b NM_001163567 uc008rac.1 uc008rac.2 uc008rac.3 Belongs to the EEIG family. uc008rac.1 uc008rac.2 uc008rac.3 
ENSMUST00000171150.8 Gm5795 ENSMUST00000171150.8 Gm5795 (from geneSymbol) E9PZN8 E9PZN8_MOUSE E9Q0N4 E9Q2D7 E9Q8Q0 EF651811 ENSMUST00000171150.1 ENSMUST00000171150.2 ENSMUST00000171150.3 ENSMUST00000171150.4 ENSMUST00000171150.5 ENSMUST00000171150.6 ENSMUST00000171150.7 F2Z428 Gm5795 uc288qgw.1 uc288qgw.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qgw.1 uc288qgw.2 
ENSMUST00000171155.4 Klhl25 ENSMUST00000171155.4 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:34491895). The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low (PubMed:22578813). The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (PubMed:22578813). The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis (PubMed:34491895). BCR(KLHL25)- mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895). (from UniProt Q8R2P1) AK143086 ENSMUST00000171155.1 ENSMUST00000171155.2 ENSMUST00000171155.3 KLH25_MOUSE Klhl25 Q8R2P1 uc009hwy.1 uc009hwy.2 uc009hwy.3 uc009hwy.4 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:34491895). The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low (PubMed:22578813). The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (PubMed:22578813). The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis (PubMed:34491895). BCR(KLHL25)- mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895). Protein modification; protein ubiquitination. Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL25 and RBX1. molecular_function cytoplasm regulation of translation regulation of translational initiation ubiquitin-dependent protein catabolic process protein ubiquitination Cul3-RING ubiquitin ligase complex uc009hwy.1 uc009hwy.2 uc009hwy.3 uc009hwy.4 
ENSMUST00000171165.8 Ube2f ENSMUST00000171165.8 Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. (from UniProt Q9CY34) AK030594 ENSMUST00000171165.1 ENSMUST00000171165.2 ENSMUST00000171165.3 ENSMUST00000171165.4 ENSMUST00000171165.5 ENSMUST00000171165.6 ENSMUST00000171165.7 Q99JK3 Q9CY34 Q9D8K0 Q9D8K7 UB2FA_MOUSE Ube2fa uc007cab.1 uc007cab.2 uc007cab.3 Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. Reaction=[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]- yl-L-cysteine.; EC=2.3.2.34; Protein modification; protein neddylation. Interacts with UBA3 and RBX2. Interacts (N-terminally acetylated form) with (via DCUN1 domain) DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5 (By similarity). Widely expressed (at protein level). The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins. Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. nucleotide binding ATP binding transferase activity NEDD8 transferase activity protein neddylation NEDD8 conjugating enzyme activity uc007cab.1 uc007cab.2 uc007cab.3 
ENSMUST00000171166.3 Sfta2 ENSMUST00000171166.3 surfactant associated 2 (from RefSeq NM_001163194.1) E9PXB6 ENSMUST00000171166.1 ENSMUST00000171166.2 NM_001163194 SFTA2_MOUSE Sfta2 uc008cid.1 uc008cid.2 uc008cid.3 Putative surfactant protein. Secreted Cytoplasmic vesicle, secretory vesicle Golgi apparatus Expressed in lung, and specifically in alveolar type II epithelial cells. Down-regulated in response to LPS (lipopolysaccharide) challenge. N-glycosylated. molecular_function cellular_component extracellular region Golgi apparatus biological_process transport vesicle cytoplasmic vesicle uc008cid.1 uc008cid.2 uc008cid.3 
ENSMUST00000171171.9 Wdr4 ENSMUST00000171171.9 WD repeat domain 4, transcript variant 1 (from RefSeq NM_021322.3) E9Q156 E9Q156_MOUSE ENSMUST00000171171.1 ENSMUST00000171171.2 ENSMUST00000171171.3 ENSMUST00000171171.4 ENSMUST00000171171.5 ENSMUST00000171171.6 ENSMUST00000171171.7 ENSMUST00000171171.8 NM_021322 Wdr4 uc008bvc.1 uc008bvc.2 uc008bvc.3 uc008bvc.4 uc008bvc.5 Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. tRNA modification; N(7)-methylguanine-tRNA biosynthesis. Nucleus Belongs to the WD repeat TRM82 family. nucleus cytosol tRNA modification tRNA processing tRNA (guanine-N7-)-methyltransferase activity tRNA methylation RNA (guanine-N7)-methylation tRNA methyltransferase complex uc008bvc.1 uc008bvc.2 uc008bvc.3 uc008bvc.4 uc008bvc.5 
ENSMUST00000171172.3 Mad2l1bp ENSMUST00000171172.3 MAD2L1 binding protein (from RefSeq NM_025649.3) ENSMUST00000171172.1 ENSMUST00000171172.2 MD2BP_MOUSE Mad2lbp NM_025649 Q99J05 Q9D0Y3 Q9DCX1 uc008cru.1 uc008cru.2 uc008cru.3 uc008cru.4 May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. Interacts with MAD2L1. Nucleus, nucleoplasm Cytoplasm, cytoskeleton, spindle Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle (By similarity). Belongs to the MAD2L1BP family. protein binding nucleus nucleoplasm nucleolus cytoplasm spindle cytoskeleton mitotic cell cycle checkpoint mitotic spindle assembly checkpoint regulation of exit from mitosis nuclear membrane uc008cru.1 uc008cru.2 uc008cru.3 uc008cru.4 
ENSMUST00000171210.3 Rad51b ENSMUST00000171210.3 RAD51 paralog B, transcript variant 1 (from RefSeq NM_009014.3) ENSMUST00000171210.1 ENSMUST00000171210.2 NM_009014 O35719 Q8BSH6 Q9D555 RA51B_MOUSE Rad51l1 Rec2 uc007oai.1 uc007oai.2 Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. The BCDX2 subcomplex RAD51B:RAD51C interacts with RAD51. Interacts with SWSAP1; involved in homologous recombination repair. Interacts with HELQ. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O35719-1; Sequence=Displayed; Name=2; IsoId=O35719-2; Sequence=VSP_008869, VSP_008870; Expressed in a wide range of tissues. Phosphorylated on tyrosine residues by BCR-ABL. Belongs to the RecA family. RAD51 subfamily. nucleotide binding double-strand break repair via homologous recombination in utero embryonic development blastocyst growth DNA binding double-stranded DNA binding single-stranded DNA binding ATP binding nucleus replication fork DNA repair DNA recombination cellular response to DNA damage stimulus DNA-dependent ATPase activity positive regulation of cell proliferation positive regulation of G2/M transition of mitotic cell cycle Rad51B-Rad51C-Rad51D-XRCC2 complex somite development four-way junction DNA binding uc007oai.1 uc007oai.2 
ENSMUST00000171213.3 Vmn2r69 ENSMUST00000171213.3 vomeronasal 2, receptor 69 (from RefSeq NM_001105182.1) ENSMUST00000171213.1 ENSMUST00000171213.2 G3XA45 G3XA45_MOUSE NM_001105182 Vmn2r69 uc012foj.1 uc012foj.2 uc012foj.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012foj.1 uc012foj.2 uc012foj.3 
ENSMUST00000171233.9 Slc37a1 ENSMUST00000171233.9 solute carrier family 37 (glycerol-3-phosphate transporter), member 1, transcript variant 2 (from RefSeq NM_153062.2) ENSMUST00000171233.1 ENSMUST00000171233.2 ENSMUST00000171233.3 ENSMUST00000171233.4 ENSMUST00000171233.5 ENSMUST00000171233.6 ENSMUST00000171233.7 ENSMUST00000171233.8 G6PT2_MOUSE NM_153062 Q3UPC2 Q8R070 Slc37a1 uc008buw.1 uc008buw.2 uc008buw.3 uc008buw.4 uc008buw.5 Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. Reaction=D-glucose 6-phosphate(in) + phosphate(out) = D-glucose 6- phosphate(out) + phosphate(in); Xref=Rhea:RHEA:71535, ChEBI:CHEBI:43474, ChEBI:CHEBI:61548; Evidence=; Inhibited by vanadate but not by chlorogenic acid. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. endoplasmic reticulum endoplasmic reticulum membrane integral component of plasma membrane carbohydrate transport antiporter activity glucose-6-phosphate transport membrane integral component of membrane transmembrane transporter activity integral component of endoplasmic reticulum membrane phosphate ion transmembrane transport transmembrane transport glucose 6-phosphate:inorganic phosphate antiporter activity uc008buw.1 uc008buw.2 uc008buw.3 uc008buw.4 uc008buw.5 
ENSMUST00000171238.8 Zfp516 ENSMUST00000171238.8 zinc finger protein 516, transcript variant 1 (from RefSeq NM_183033.2) ENSMUST00000171238.1 ENSMUST00000171238.2 ENSMUST00000171238.3 ENSMUST00000171238.4 ENSMUST00000171238.5 ENSMUST00000171238.6 ENSMUST00000171238.7 Kiaa0222 NM_183033 Q7TSH3 ZN516_MOUSE Zfp516 Znf516 uc008fuf.1 uc008fuf.2 uc008fuf.3 Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress (By similarity). Interacts with PRDM16; the interaction is direct and may play a role in the transcription of brown adipose tissue-specific genes (PubMed:25578880). Interacts with PWWP2B (PubMed:34180153). Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B (PubMed:34180153). Nucleus Expressed by adipocytes more specifically in brown adipose tissue compared to white adipose tissue (WAT). Up-regulated in response to cold in brown and subcutaneous white adipose tissue where it may regulate non-shivering thermogenesis (at protein level). Knockout mice die immediately after birth. 20.5 dpc embryos display an impaired development of brown adipose tissue. Belongs to the krueppel C2H2-type zinc-finger protein family. core promoter proximal region sequence-specific DNA binding nucleic acid binding DNA binding nucleus response to cold activating transcription factor binding positive regulation of transcription, DNA-templated metal ion binding brown fat cell differentiation adipose tissue development uc008fuf.1 uc008fuf.2 uc008fuf.3 
ENSMUST00000171248.2 Gm17110 ENSMUST00000171248.2 Gm17110 (from geneSymbol) ENSMUST00000171248.1 uc288sjt.1 uc288sjt.2 uc288sjt.1 uc288sjt.2 
ENSMUST00000171249.6 Nudt17 ENSMUST00000171249.6 nudix hydrolase 17, transcript variant 1 (from RefSeq NM_030094.1) ENSMUST00000171249.1 ENSMUST00000171249.2 ENSMUST00000171249.3 ENSMUST00000171249.4 ENSMUST00000171249.5 NM_030094 NUD17_MOUSE Q14BX3 Q3URR9 Q9CWD3 uc008qnz.1 uc008qnz.2 uc008qnz.3 uc008qnz.4 Probably mediates the hydrolysis of some nucleoside diphosphate derivatives. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CWD3-1; Sequence=Displayed; Name=2; IsoId=Q9CWD3-2; Sequence=VSP_037799; Belongs to the Nudix hydrolase family. peroxisome cytosol NADH metabolic process NADP catabolic process hydrolase activity NAD catabolic process NADH pyrophosphatase activity metal ion binding uc008qnz.1 uc008qnz.2 uc008qnz.3 uc008qnz.4 
ENSMUST00000171251.8 Arid3c ENSMUST00000171251.8 AT-rich interaction domain 3C, transcript variant 1 (from RefSeq NM_001017362.3) A6PWV5 ARI3C_MOUSE B2RUN0 ENSMUST00000171251.1 ENSMUST00000171251.2 ENSMUST00000171251.3 ENSMUST00000171251.4 ENSMUST00000171251.5 ENSMUST00000171251.6 ENSMUST00000171251.7 NM_001017362 uc008sjj.1 uc008sjj.2 This gene is a member of the ARID (AT-rich interaction domain) family of proteins. The ARID domain is a helix-turn-helix motif-based DNA-binding domain. ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]. Nucleus Sequence=CAM16056.2; Type=Erroneous gene model prediction; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding protein binding nucleus cytoplasm membrane raft positive regulation of transcription from RNA polymerase II promoter uc008sjj.1 uc008sjj.2 
ENSMUST00000171292.8 Ralgps2 ENSMUST00000171292.8 Ral GEF with PH domain and SH3 binding motif 2, transcript variant 3 (from RefSeq NM_001159966.1) ENSMUST00000171292.1 ENSMUST00000171292.2 ENSMUST00000171292.3 ENSMUST00000171292.4 ENSMUST00000171292.5 ENSMUST00000171292.6 ENSMUST00000171292.7 NM_001159966 Q7TPZ6 Q80YA6 Q8BZ37 Q8BZU2 Q9D2Y7 Q9ERD6 RGPS2_MOUSE uc011wui.1 uc011wui.2 uc011wui.3 Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion. Interacts with RALA (By similarity). Interacts with the SH3 domains of GRB2 and PLCG1. Cytoplasm Cell membrane Note=Associates with membranes through the PH domain. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9ERD6-1; Sequence=Displayed; Name=2; IsoId=Q9ERD6-2; Sequence=VSP_031972; Name=3; IsoId=Q9ERD6-3; Sequence=VSP_031973; Name=4; IsoId=Q9ERD6-4; Sequence=VSP_031974, VSP_031975; Abundant in brain and testis. The PH domain mediates binding to phosphatidylinositol 4,5- bisphosphate. molecular_function guanyl-nucleotide exchange factor activity cellular_component cytoplasm plasma membrane small GTPase mediated signal transduction biological_process membrane regulation of Ral protein signal transduction uc011wui.1 uc011wui.2 uc011wui.3 
ENSMUST00000171297.2 F830016B08Rik ENSMUST00000171297.2 RIKEN cDNA F830016B08 gene (from RefSeq NM_001101475.2) ENSMUST00000171297.1 F830016B08Rik G3UWE2 G3UWE2_MOUSE Ifgga4 NM_001101475 uc008faa.1 uc008faa.2 uc008faa.3 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. GTPase activity GTP binding endoplasmic reticulum membrane defense response membrane integral component of membrane cellular response to interferon-beta uc008faa.1 uc008faa.2 uc008faa.3 
ENSMUST00000171300.8 Sumf2 ENSMUST00000171300.8 sulfatase modifying factor 2, transcript variant 1 (from RefSeq NM_026445.3) ENSMUST00000171300.1 ENSMUST00000171300.2 ENSMUST00000171300.3 ENSMUST00000171300.4 ENSMUST00000171300.5 ENSMUST00000171300.6 ENSMUST00000171300.7 NM_026445 Q3TZL1 Q3UUL0 Q8BPG6 Q9CZ47 SUMF2_MOUSE Sumf2 uc008ztk.1 uc008ztk.2 uc008ztk.3 Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Homodimer and heterodimer with SUMF1. Endoplasmic reticulum lumen The non-canonical ER retention motif mediates retention of the protein in the endoplasmic reticulum. Belongs to the sulfatase-modifying factor family. Although strongly similar to formylglycine-generating enzyme, lacks the catalytic Cys residues that bind the catalytic copper. The catalytic copper is required to activate oxygen and catalyze oxidative C-H activation. Sequence=BAE23615.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding endoplasmic reticulum endoplasmic reticulum lumen biological_process protein homodimerization activity metal ion binding uc008ztk.1 uc008ztk.2 uc008ztk.3 
ENSMUST00000171305.2 Gm7876 ENSMUST00000171305.2 Gm7876 (from geneSymbol) ENSMUST00000171305.1 Gm3182 Gm7876 K7N6T8 K7N6T8_MOUSE uc288qkn.1 uc288qkn.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qkn.1 uc288qkn.2 
ENSMUST00000171313.8 Rrh ENSMUST00000171313.8 Membrane ; Multi- pass membrane protein (from UniProt Q543W9) AK044717 ENSMUST00000171313.1 ENSMUST00000171313.2 ENSMUST00000171313.3 ENSMUST00000171313.4 ENSMUST00000171313.5 ENSMUST00000171313.6 ENSMUST00000171313.7 Q543W9 Q543W9_MOUSE Rrh uc290jql.1 uc290jql.2 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway visual perception photoreceptor activity membrane integral component of membrane protein-chromophore linkage response to stimulus uc290jql.1 uc290jql.2 
ENSMUST00000171317.2 Spmip1 ENSMUST00000171317.2 sperm microtubule inner protein 1 (from RefSeq NM_001145360.1) ATp6v1fnb B9EJX3 ENSMUST00000171317.1 Gm9047 NM_001145360 SMIP1_MOUSE uc012ejd.1 uc012ejd.2 uc012ejd.3 molecular_function cellular_component biological_process uc012ejd.1 uc012ejd.2 uc012ejd.3 
ENSMUST00000171319.5 Gm3646 ENSMUST00000171319.5 Gm3646 (from geneSymbol) AK086013 ENSMUST00000171319.1 ENSMUST00000171319.2 ENSMUST00000171319.3 ENSMUST00000171319.4 uc007ato.1 uc007ato.2 uc007ato.3 uc007ato.4 uc007ato.5 uc007ato.1 uc007ato.2 uc007ato.3 uc007ato.4 uc007ato.5 
ENSMUST00000171322.3 Semp2l1 ENSMUST00000171322.3 SUMO/sentrin specific peptidase 2-like 1 (from RefSeq NM_001164286.1) E9PXF3 E9PXF3_MOUSE ENSMUST00000171322.1 ENSMUST00000171322.2 Gm5415 NM_001164286 Semp2l1 uc011wiw.1 uc011wiw.2 uc011wiw.3 Belongs to the peptidase C48 family. nucleus proteolysis cysteine-type peptidase activity protein desumoylation uc011wiw.1 uc011wiw.2 uc011wiw.3 
ENSMUST00000171324.3 Gcnt4 ENSMUST00000171324.3 glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase), transcript variant 1 (from RefSeq NM_001376999.1) E9Q649 ENSMUST00000171324.1 ENSMUST00000171324.2 GCNT4_MOUSE NM_001376999 uc007rno.1 uc007rno.2 uc007rno.3 uc007rno.4 Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O- glycan or I-branching enzyme activity. Reaction=O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl- (1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:56212, Rhea:RHEA-COMP:13922, Rhea:RHEA- COMP:14419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:137949, ChEBI:CHEBI:139605; EC=2.4.1.102; Evidence=; Reaction=O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D- glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D- glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl- [protein] + H(+) + UDP; Xref=Rhea:RHEA:56216, Rhea:RHEA-COMP:13923, Rhea:RHEA-COMP:14420, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:137950, ChEBI:CHEBI:139607; EC=2.4.1.102; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein Belongs to the glycosyltransferase 14 family. Golgi membrane inter-male aggressive behavior beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Golgi apparatus protein glycosylation acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups thyroid hormone metabolic process tissue morphogenesis homeostasis of number of cells kidney morphogenesis uc007rno.1 uc007rno.2 uc007rno.3 uc007rno.4 
ENSMUST00000171330.7 Slamf6 ENSMUST00000171330.7 SLAM family member 6, transcript variant 1 (from RefSeq NM_030710.3) C6ESQ1 ENSMUST00000171330.1 ENSMUST00000171330.2 ENSMUST00000171330.3 ENSMUST00000171330.4 ENSMUST00000171330.5 ENSMUST00000171330.6 Ly108 NM_030710 Q9ET39 Q9ET40 SLAF6_MOUSE uc007dpg.1 uc007dpg.2 uc007dpg.3 Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922). Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (By similarity). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (By similarity). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (PubMed:18031695). Promotes T cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (By similarity). Promotes recruitment of RORC to the IL-17 promoter (By similarity). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response (PubMed:25926831). In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T- cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP (PubMed:22683125). However, reported to mediated T-cell adhesion, to participate in stable T-cell:B-cell interactions and to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (PubMed:20153220, PubMed:25801429). Involved in regulation of autoimmunity. Isoform 3 may be suppressor of pathogenic T-cell proliferation (PubMed:21422172). Homodimer. Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP (By similarity). Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Ly108s; IsoId=Q9ET39-1; Sequence=Displayed; Name=2; Synonyms=Ly108l; IsoId=Q9ET39-2; Sequence=VSP_010404, VSP_010405; Name=3; Synonyms=Ly108-H1; IsoId=Q9ET39-3; Sequence=VSP_058034; Expressed on hematopoietic cells. Isoform 3 is expressed in thymocytes and B lymphocytes of C57Bl/6 strain. The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain- containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'two-out-of-three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3). Phosphorylated. Isoform 3 ameliorates spontaneous development in a systemic lupus erythematosus transfer model. [Isoform 3]: Found in Slamf-haplotype 1 mice such as C557Bl/6 but not in Slamf-haplotype 2 strains including 129, Balb/c and NOD. natural killer cell differentiation natural killer cell proliferation adaptive immune response immune system process plasma membrane integral component of plasma membrane membrane integral component of membrane positive regulation of interferon-gamma production positive regulation of interleukin-17 production innate immune response positive regulation of natural killer cell mediated cytotoxicity T-helper 17 cell lineage commitment uc007dpg.1 uc007dpg.2 uc007dpg.3 
ENSMUST00000171332.2 Hspg2 ENSMUST00000171332.2 perlecan (heparan sulfate proteoglycan 2) (from RefSeq NM_008305.4) E9PZ16 E9PZ16_MOUSE ENSMUST00000171332.1 Hspg2 NM_008305 uc008vjc.1 uc008vjc.2 uc008vjc.3 uc008vjc.4 Secreted, extracellular space, extracellular matrix, basement membrane Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding protein C-terminus binding uc008vjc.1 uc008vjc.2 uc008vjc.3 uc008vjc.4 
ENSMUST00000171337.10 Sorbs2 ENSMUST00000171337.10 sorbin and SH3 domain containing 2, transcript variant 1 (from RefSeq NM_001205219.1) B9EKP8 B9EKP8_MOUSE ENSMUST00000171337.1 ENSMUST00000171337.2 ENSMUST00000171337.3 ENSMUST00000171337.4 ENSMUST00000171337.5 ENSMUST00000171337.6 ENSMUST00000171337.7 ENSMUST00000171337.8 ENSMUST00000171337.9 NM_001205219 Sorbs2 uc012gde.1 uc012gde.2 uc012gde.3 uc012gde.4 nucleic acid binding nucleoplasm actin filament organization uc012gde.1 uc012gde.2 uc012gde.3 uc012gde.4 
ENSMUST00000171342.3 Rnf41 ENSMUST00000171342.3 ring finger protein 41, transcript variant 3 (from RefSeq NR_104288.1) ENSMUST00000171342.1 ENSMUST00000171342.2 Flrf NR_104288 Nrdp1 Q8BGJ2 Q8BH75 Q8BMC9 Q8VEA2 Q9CRK6 Q9D568 RNF41_MOUSE uc007hmu.1 uc007hmu.2 uc007hmu.3 uc007hmu.4 Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of pro- inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3 (PubMed:19483718). Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (PubMed:18495327). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with USP8, ERBB3, PRKN and BIRC6 (By similarity). Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1. Interacts with Clec16a (PubMed:24949970). Q8BH75; Q80U30-2: Clec16a; NbExp=3; IntAct=EBI-7059583, EBI-9696757; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BH75-1; Sequence=Displayed; Name=2; IsoId=Q8BH75-2; Sequence=VSP_058649, VSP_058650; Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=AAH19415.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC27496.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; Sequence=BAC31779.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; protein polyubiquitination ubiquitin-protein transferase activity erythropoietin receptor binding interleukin-3 receptor binding protein binding autophagy apoptotic process zinc ion binding negative regulation of cell proliferation regulation of gene expression proteasomal protein catabolic process protein ubiquitination transferase activity Ral GTPase binding protein domain specific binding negative regulation of cell migration receptor tyrosine kinase binding regulation of MAPK cascade regulation of lymphocyte differentiation regulation of myeloid cell differentiation positive regulation of protein catabolic process metal ion binding perinuclear region of cytoplasm positive regulation of sequence-specific DNA binding transcription factor activity protein autoubiquitination regulation of protein kinase B signaling ubiquitin protein ligase activity endoplasmic reticulum tubular network extrinsic apoptotic signaling pathway negative regulation of macromitophagy regulation of establishment of cell polarity regulation of reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process uc007hmu.1 uc007hmu.2 uc007hmu.3 uc007hmu.4 
ENSMUST00000171347.9 Ctla2b ENSMUST00000171347.9 cytotoxic T lymphocyte-associated protein 2 beta, transcript variant 2 (from RefSeq NM_001145801.1) A0A0R4J245 A0A0R4J245_MOUSE Ctla2b ENSMUST00000171347.1 ENSMUST00000171347.2 ENSMUST00000171347.3 ENSMUST00000171347.4 ENSMUST00000171347.5 ENSMUST00000171347.6 ENSMUST00000171347.7 ENSMUST00000171347.8 NM_001145801 uc007qvt.1 uc007qvt.2 uc007qvt.3 uc007qvt.4 uc007qvt.1 uc007qvt.2 uc007qvt.3 uc007qvt.4 
ENSMUST00000171348.9 Msantd5f2 ENSMUST00000171348.9 Myb/SANT DNA binding domain containing 5 family member 2 (from RefSeq NM_001277487.1) E9Q5Z9 E9Q5Z9_MOUSE ENSMUST00000171348.1 ENSMUST00000171348.2 ENSMUST00000171348.3 ENSMUST00000171348.4 ENSMUST00000171348.5 ENSMUST00000171348.6 ENSMUST00000171348.7 ENSMUST00000171348.8 Gm11239 Msantd5f2 NM_001277487 uc290nhs.1 uc290nhs.2 This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is inferred from alignment of paralogous transcripts. [provided by RefSeq, Apr 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments and paralogous data. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## molecular_function cellular_component biological_process uc290nhs.1 uc290nhs.2 
ENSMUST00000171360.4 Gm10128 ENSMUST00000171360.4 Gm10128 (from geneSymbol) EF651814 ENSMUST00000171360.1 ENSMUST00000171360.2 ENSMUST00000171360.3 Gm10128 Gm10340 K7N708 K7N708_MOUSE L7N2B6 uc288qqt.1 uc288qqt.2 uc288qqt.3 molecular_function cellular_component biological_process uc288qqt.1 uc288qqt.2 uc288qqt.3 
ENSMUST00000171362.2 Tstd1 ENSMUST00000171362.2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 (from RefSeq NM_001164525.1) E9PY03 E9PY03_MOUSE ENSMUST00000171362.1 NM_001164525 Tstd1 uc011wwd.1 uc011wwd.2 molecular_function cytoplasm mitochondrion cytosol biological_process cytoplasmic ribonucleoprotein granule thiosulfate-thiol sulfurtransferase activity sulfide oxidation, using sulfide:quinone oxidoreductase uc011wwd.1 uc011wwd.2 
ENSMUST00000171380.3 Platr19 ENSMUST00000171380.3 Platr19 (from geneSymbol) AK039157 ENSMUST00000171380.1 ENSMUST00000171380.2 uc288eyl.1 uc288eyl.2 uc288eyl.3 uc288eyl.1 uc288eyl.2 uc288eyl.3 
ENSMUST00000171394.3 Insyn2a ENSMUST00000171394.3 inhibitory synaptic factor 2A (from RefSeq NM_001143802.1) E9PZW7 E9PZW7_MOUSE ENSMUST00000171394.1 ENSMUST00000171394.2 Fam196a Insyn2a NM_001143802 uc012fvi.1 uc012fvi.2 uc012fvi.3 uc012fvi.1 uc012fvi.2 uc012fvi.3 
ENSMUST00000171400.4 Lrrc10b ENSMUST00000171400.4 leucine rich repeat containing 10B (from RefSeq NM_001111140.2) ENSMUST00000171400.1 ENSMUST00000171400.2 ENSMUST00000171400.3 G3XA50 G3XA50_MOUSE Lrrc10b NM_001111140 uc012bio.1 uc012bio.2 uc012bio.3 uc012bio.4 molecular_function cellular_component biological_process uc012bio.1 uc012bio.2 uc012bio.3 uc012bio.4 
ENSMUST00000171425.4 C5ar2 ENSMUST00000171425.4 complement component 5a receptor 2, transcript variant 1 (from RefSeq NM_176912.5) B2RQI1 C5AR2_MOUSE C5l2 ENSMUST00000171425.1 ENSMUST00000171425.2 ENSMUST00000171425.3 Gpr77 NM_176912 Q3TVM8 Q8BW93 uc009fhk.1 uc009fhk.2 uc009fhk.3 uc009fhk.4 uc009fhk.5 Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways (By similarity). Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77. Cell membrane; Multi-pass membrane protein. Highly expressed in liver and spleen. Lower levels in intestine, brain and kidney. Also expressed in adipose tissues with highest levels in gonadal and ingual fat depots. Lower levels in brown tissue. Belongs to the G-protein coupled receptor 1 family. Sequence=BAE35590.1; Type=Erroneous initiation; Evidence=; complement receptor mediated signaling pathway complement component C5a receptor activity G-protein coupled receptor activity plasma membrane chemotaxis inflammatory response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration basal plasma membrane membrane integral component of membrane negative regulation of tumor necrosis factor production complement component C5a signaling pathway apical part of cell positive regulation of epithelial cell proliferation positive regulation of ERK1 and ERK2 cascade negative regulation of neutrophil chemotaxis negative regulation of interleukin-6 secretion regulation of interleukin-8 secretion uc009fhk.1 uc009fhk.2 uc009fhk.3 uc009fhk.4 uc009fhk.5 
ENSMUST00000171427.8 Grm6 ENSMUST00000171427.8 glutamate receptor, metabotropic 6 (from RefSeq NM_173372.2) ENSMUST00000171427.1 ENSMUST00000171427.2 ENSMUST00000171427.3 ENSMUST00000171427.4 ENSMUST00000171427.5 ENSMUST00000171427.6 ENSMUST00000171427.7 GRM6_MOUSE Gprc1f Mglur6 NM_173372 Q5NCH9 uc007isu.1 uc007isu.2 uc007isu.3 uc007isu.4 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. Homodimer (By similarity). Interacts with GPR179 (PubMed:24114537). Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi- pass membrane protein Cell projection, dendrite. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane (By similarity). Detected at dendritic tips of bipolar cells. Detected in the outer plexiform layer in retina (at protein level). Retinal cells from mutant mice display a subtly altered response to cycles of light and darkness, due to a failure of the ON bipolar cells in the retina to become depolarized in response to light. As a consequence, mutant mice display little or no pupillary contraction in adaptation to low light intensity. Besides, they exhibit strongly impaired responses to moving stimuli, and fail to produce a response when the visual constrast is low. Besides, rod bipolar cells from mutant mice lack TRPM1 channel activity. Belongs to the G-protein coupled receptor 3 family. Golgi membrane adenylate cyclase inhibiting G-protein coupled glutamate receptor activity group III metabotropic glutamate receptor activity G-protein coupled receptor activity endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway chemical synaptic transmission visual perception locomotory behavior glutamate receptor activity membrane integral component of membrane dendrite new growing cell tip protein homodimerization activity cell projection postsynaptic membrane response to stimulus detection of light stimulus involved in visual perception sensory perception of light stimulus regulation of synaptic transmission, glutamatergic retina development in camera-type eye positive regulation of calcium ion import uc007isu.1 uc007isu.2 uc007isu.3 uc007isu.4 
ENSMUST00000171428.8 Gm8206 ENSMUST00000171428.8 Gm8206 (from geneSymbol) EF651826 ENSMUST00000171428.1 ENSMUST00000171428.2 ENSMUST00000171428.3 ENSMUST00000171428.4 ENSMUST00000171428.5 ENSMUST00000171428.6 ENSMUST00000171428.7 Gm8206 L7N295 L7N295_MOUSE uc288qnn.1 uc288qnn.2 uc288qnn.1 uc288qnn.2 
ENSMUST00000171436.8 Pacsin2 ENSMUST00000171436.8 protein kinase C and casein kinase substrate in neurons 2, transcript variant 11 (from RefSeq NR_177947.1) ENSMUST00000171436.1 ENSMUST00000171436.2 ENSMUST00000171436.3 ENSMUST00000171436.4 ENSMUST00000171436.5 ENSMUST00000171436.6 ENSMUST00000171436.7 NR_177947 PACN2_MOUSE Q9WVE8 uc011zxc.1 uc011zxc.2 Regulates the morphogenesis and endocytosis of caveolae (PubMed:21807942). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. Homodimer (PubMed:20471395). May form heterooligomers with other PACSINs (PubMed:11082044). Interacts (via NPF motifs) with EHD1 (via EH domain) (PubMed:15930129). Interacts (via NPF motifs) with EHD2 (via EH domain); this interaction probably stabilizes the caveolae (By similarity). Interacts with EHD3 (PubMed:15930129). Interacts (via the SH3 domain) with MICALL1 (By similarity). Interacts with RAC1 (PubMed:21693584). Interacts (via SH3 domain) with DNM1, SYN1, SYNJ1 and WASL (PubMed:11082044). Interacts (via F-BAR domain) with CAV1; this interaction induces membrane tubulation (PubMed:21610094). Interacts with TRPV4 (PubMed:16627472). Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection Membrane, caveola te=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1. Widely expressed (at protein level). The F-BAR domain forms a coiled coil and mediates membrane- binding and membrane tubulation (PubMed:20188097, PubMed:20471395). Autoinhibition of these functions is mediated by an interaction between the SH3 and F-BAR domains (By similarity). The F-Bar domain also mediates the binding to the cell actin cytoskeleton through the interaction with CAV-1 (PubMed:21610094). Phosphorylated by casein kinase 2 (CK2). Phosphorylation by PKC probably decreases the membrane binding and tubulation capacities of PACSIN2, thereby modulating the lifetime of caveolae (PubMed:26092940). Results in loss of morphologically defined caveolae. Belongs to the PACSIN family. protein binding phospholipid binding cytoplasm endosome early endosome cytosol cytoskeleton plasma membrane caveola cell-cell junction endocytosis cytoskeleton organization signal transduction cytoskeletal protein binding lipid binding membrane nuclear speck extrinsic component of membrane actin cytoskeleton organization cytoplasmic vesicle membrane cytoplasmic vesicle ruffle membrane protein localization to endosome identical protein binding cell projection intracellular membrane-bounded organelle negative regulation of endocytosis cell projection morphogenesis modulation of synaptic transmission recycling endosome membrane phosphatidic acid binding caveola assembly caveolin-mediated endocytosis plasma membrane tubulation glutamatergic synapse trans-Golgi network uc011zxc.1 uc011zxc.2 
ENSMUST00000171458.2 Klk11 ENSMUST00000171458.2 kallikrein related-peptidase 11, transcript variant 2 (from RefSeq NM_019974.2) ENSMUST00000171458.1 KLK11_MOUSE NM_019974 Prss20 Q9QYN3 Q9QYN4 uc012fjj.1 uc012fjj.2 uc012fjj.3 uc012fjj.4 This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]. Possible multifunctional protease. Efficiently cleaves 'bz- Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin (By similarity). Secreted. Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q9QYN3-1; Sequence=Displayed; Name=1; IsoId=Q9QYN3-2; Sequence=VSP_017318; Expressed in brain and prostate (isoform 1) and prostate (isoform 2). Belongs to the peptidase S1 family. Kallikrein subfamily. serine-type endopeptidase activity extracellular region proteolysis peptidase activity serine-type peptidase activity hydrolase activity secretory granule uc012fjj.1 uc012fjj.2 uc012fjj.3 uc012fjj.4 
ENSMUST00000171460.8 Prr5 ENSMUST00000171460.8 proline rich 5 (renal), transcript variant 2 (from RefSeq NM_001346662.1) ENSMUST00000171460.1 ENSMUST00000171460.2 ENSMUST00000171460.3 ENSMUST00000171460.4 ENSMUST00000171460.5 ENSMUST00000171460.6 ENSMUST00000171460.7 NM_001346662 PRR5_MOUSE Protor1 Prr5 Q5EAK2 Q812A5 Q8BIE7 Q8BIK1 Q8R1A0 uc007xce.1 uc007xce.2 Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer (By similarity). Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (By similarity). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and RICTOR within the TORC2 complex (By similarity). Interacts with MTOR. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q812A5-1; Sequence=Displayed; Name=2 ; IsoId=Q812A5-2; Sequence=VSP_052580; Ubiquitously expressed. Expressed at high levels in kidney. Belongs to the PROTOR family. Was originally thought to be the sequence of Arhgap8 but is actually the sequence of Prr5. Sequence=BAC32586.1; Type=Frameshift; Evidence=; positive regulation of protein phosphorylation GTPase activator activity cell cycle positive regulation of phosphatidylinositol 3-kinase signaling actin cytoskeleton organization positive regulation of cell migration TORC2 complex TORC2 signaling positive regulation of GTPase activity uc007xce.1 uc007xce.2 
ENSMUST00000171466.2 Zfp595 ENSMUST00000171466.2 zinc finger protein 595, transcript variant 2 (from RefSeq NM_001374733.1) B9EIT6 B9EIT6_MOUSE ENSMUST00000171466.1 NM_001374733 Zfp595 uc288oei.1 uc288oei.2 nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc288oei.1 uc288oei.2 
ENSMUST00000171470.8 Lox ENSMUST00000171470.8 lysyl oxidase, transcript variant 3 (from RefSeq NM_001286182.1) ENSMUST00000171470.1 ENSMUST00000171470.2 ENSMUST00000171470.3 ENSMUST00000171470.4 ENSMUST00000171470.5 ENSMUST00000171470.6 ENSMUST00000171470.7 Lox NM_001286182 Q3TXH3 Q3TXH3_MOUSE uc008exf.1 uc008exf.2 uc008exf.3 uc008exf.4 This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]. Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Reaction=H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl- [protein] + H2O2 + NH4(+); Xref=Rhea:RHEA:24544, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:12448, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:131803; EC=1.4.3.13; Evidence= Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence= Secreted, extracellular space The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Belongs to the lysyl oxidase family. protein-lysine 6-oxidase activity copper ion binding collagen binding extracellular space nucleus response to hormone oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor peptidyl-lysine oxidation protein oxidation collagen fibril organization extracellular matrix platelet-derived growth factor receptor-beta signaling pathway wound healing response to drug elastic fiber assembly response to steroid hormone oxidation-reduction process cell chemotaxis regulation of receptor binding uc008exf.1 uc008exf.2 uc008exf.3 uc008exf.4 
ENSMUST00000171473.3 H4c14 ENSMUST00000171473.3 H4 clustered histone 14 (from RefSeq NM_033596.3) A0AUM5 A4FUP8 A4QMY0 ENSMUST00000171473.1 ENSMUST00000171473.2 H4-12 H4-53 H4_MOUSE H4c1 H4c11 H4c12 H4c16 H4c2 H4c3 H4c4 H4c6 H4c8 H4c9 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist1h4m Hist2h4 Hist2h4a Hist4h4 NM_033596 P02304 P02305 P62806 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 uc008qmn.1 uc008qmn.2 uc008qmn.3 uc008qmn.4 uc008qmn.5 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3- H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). P62806; Q8CDM1: Atad2; NbExp=2; IntAct=EBI-299632, EBI-2944582; P62806; Q9EQQ9: Oga; NbExp=2; IntAct=EBI-299632, EBI-8321615; Nucleus Chromosome Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Sumoylated, which is associated with transcriptional repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H4 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly DNA-templated transcription, initiation protein domain specific binding macromolecular complex negative regulation of megakaryocyte differentiation protein heterodimerization activity protein heterotetramerization uc008qmn.1 uc008qmn.2 uc008qmn.3 uc008qmn.4 uc008qmn.5 
ENSMUST00000171496.9 Scube1 ENSMUST00000171496.9 signal peptide, CUB domain, EGF-like 1, transcript variant 2 (from RefSeq NM_022723.3) ENSMUST00000171496.1 ENSMUST00000171496.2 ENSMUST00000171496.3 ENSMUST00000171496.4 ENSMUST00000171496.5 ENSMUST00000171496.6 ENSMUST00000171496.7 ENSMUST00000171496.8 NM_022723 Q6NZL8 Q8C9Q4 Q9EQC6 SCUB1_MOUSE uc007xbi.1 uc007xbi.2 uc007xbi.3 uc007xbi.4 Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. Forms homooligomers and heterooligomers with SCUBE2 and SCUBE3. Secreted Cell membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6NZL8-1; Sequence=Displayed; Name=2; IsoId=Q6NZL8-2; Sequence=VSP_021271; Name=3; IsoId=Q6NZL8-3; Sequence=VSP_021271, VSP_021272, VSP_021273; Expressed predominantly in the developing gonad, nervous system somites, surface ectoderm and limb buds. Down-regulated by inflammatory cytokines. N-glycosylated. Could be proteolytically cleaved to release a smaller active fragment. calcium ion binding extracellular region extracellular space plasma membrane external side of plasma membrane cell surface membrane extrinsic component of plasma membrane identical protein binding positive regulation of smoothened signaling pathway protein heterodimerization activity protein homooligomerization uc007xbi.1 uc007xbi.2 uc007xbi.3 uc007xbi.4 
ENSMUST00000171498.3 Smok3a ENSMUST00000171498.3 sperm motility kinase 3A, transcript variant 2 (from RefSeq NM_001126045.1) C0HKC9 ENSMUST00000171498.1 ENSMUST00000171498.2 NM_001126045 Q9QYZ5 SMK3B_MOUSE Smok3b uc012eff.1 uc012eff.2 uc012eff.3 May play a role in sperm motility, especially in the regulation of flagellar function. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Testis-specific. Expressed in the testis from 22 days postpartum (22 dpp). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity intracellular signal transduction uc012eff.1 uc012eff.2 uc012eff.3 
ENSMUST00000171534.8 Rbmy ENSMUST00000171534.8 RNA binding motif protein, Y chromosome, transcript variant 2 (from RefSeq NM_001166384.1) E9Q856 ENSMUST00000171534.1 ENSMUST00000171534.2 ENSMUST00000171534.3 ENSMUST00000171534.4 ENSMUST00000171534.5 ENSMUST00000171534.6 ENSMUST00000171534.7 NM_001166384 O35698 RBY1A_MOUSE Rbm Rbmy1a1 uc012hry.1 uc012hry.2 uc012hry.3 uc012hry.4 RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. Nucleus Testis-specific. Only expressed in spermatogonia and early spermatocytes, suggesting that expression is inactivated in the XY body during meiosis. The RBMY1 proteins are encoded by repeated regions of the Y chromosome. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. Overexpression of Rbmy proteins in mice carrying the Y(d1) deletion that removes most of the multi-copy Rbmy gene cluster does not have any effect and fails to reduce the frequency of abnormal sperm. These results raize the question of the role of Rbmy proteins in sperm development. male germ cell nucleus hematopoietic progenitor cell differentiation nucleic acid binding RNA binding nucleus spliceosomal complex mRNA processing RNA splicing positive regulation of mRNA splicing, via spliceosome ribonucleoprotein complex uc012hry.1 uc012hry.2 uc012hry.3 uc012hry.4 
ENSMUST00000171542.2 Krtap11-1 ENSMUST00000171542.2 keratin associated protein 11-1 (from RefSeq NM_001113406.1) E9Q2E9 E9Q2E9_MOUSE ENSMUST00000171542.1 Krtap11-1 NM_001113406 uc012aic.1 uc012aic.2 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the PMG family. molecular_function cellular_component biological_process uc012aic.1 uc012aic.2 
ENSMUST00000171556.8 Kif1a ENSMUST00000171556.8 kinesin family member 1A, transcript variant 2 (from RefSeq NM_001110315.3) E9QAN4 E9QAN4_MOUSE ENSMUST00000171556.1 ENSMUST00000171556.2 ENSMUST00000171556.3 ENSMUST00000171556.4 ENSMUST00000171556.5 ENSMUST00000171556.6 ENSMUST00000171556.7 Kif1a NM_001110315 uc007cdg.1 uc007cdg.2 uc007cdg.3 uc007cdg.4 uc007cdg.5 Cytoplasm, cytoskeleton Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding motor activity microtubule motor activity ATP binding microtubule-based movement microtubule binding uc007cdg.1 uc007cdg.2 uc007cdg.3 uc007cdg.4 uc007cdg.5 
ENSMUST00000171561.8 Mms19 ENSMUST00000171561.8 MMS19 cytosolic iron-sulfur assembly component, transcript variant 3 (from RefSeq NR_164197.1) ENSMUST00000171561.1 ENSMUST00000171561.2 ENSMUST00000171561.3 ENSMUST00000171561.4 ENSMUST00000171561.5 ENSMUST00000171561.6 ENSMUST00000171561.7 F8WHX3 MMS19_MOUSE Mms19 Mms19l NR_164197 Q925N8 Q9CWX3 Q9D071 uc008hmw.1 uc008hmw.2 uc008hmw.3 Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target Fe/S proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As a CIA complex component and in collaboration with CIAO1 and CIAO2, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. Component of the CIA complex. In the CIA complex, interacts directly with CIAO2B and CIAO3. Component of the MMXD complex, composed of CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5. Interacts with CIAO2B; the interaction is direct. Interacts with ERCC2/XPD; the interaction is direct. Interacts with ERCC3/XPB and NCOA3/RAC3. Interacts with RTEL1; the interaction mediates the association of RTEL1 with the CIA complex. Interacts with BRIP1. Interacts with KIF4A; the interaction facilitates the transfer of Fe-S clusters to KIF4A to ensure proper localization of KIF4A to the mitotic machinery components. Interacts with CCDC117; the interaction is indirect (By similarity). Nucleus Cytoplasm, cytoskeleton, spindle Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9D071-1; Sequence=Displayed; Name=2; IsoId=Q9D071-2; Sequence=VSP_015569, VSP_015570; Name=3; IsoId=Q9D071-3; Sequence=VSP_044184; Ubiquitously expressed with higher expression in testis. Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination. Embryonically lethality before the implantation stage. Belongs to the MET18/MMS19 family. transcription coactivator activity nucleus nucleoplasm cytoplasm spindle cytosol cytoskeleton DNA metabolic process DNA repair cellular response to DNA damage stimulus chromosome segregation iron-sulfur cluster assembly enzyme binding estrogen receptor binding positive regulation of transcription, DNA-templated MMXD complex CIA complex protein maturation by iron-sulfur cluster transfer positive regulation of double-strand break repair via homologous recombination uc008hmw.1 uc008hmw.2 uc008hmw.3 
ENSMUST00000171622.2 Vmn1r143 ENSMUST00000171622.2 vomeronasal 1 receptor 143 (from RefSeq NM_001166750.1) E9PUW9 E9PUW9_MOUSE ENSMUST00000171622.1 NM_001166750 Vmn1r143 Vmn1r95 uc012fdt.1 uc012fdt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fdt.1 uc012fdt.2 
ENSMUST00000171629.3 Arhgef37 ENSMUST00000171629.3 Rho guanine nucleotide exchange factor 37 (from RefSeq NM_177828.4) Arhgef37 E9Q5R6 E9Q5R6_MOUSE ENSMUST00000171629.1 ENSMUST00000171629.2 NM_177828 uc008fca.1 uc008fca.2 uc008fca.3 uc008fca.4 Rho guanyl-nucleotide exchange factor activity cytoplasm regulation of Rho protein signal transduction uc008fca.1 uc008fca.2 uc008fca.3 uc008fca.4 
ENSMUST00000171644.8 Pparg ENSMUST00000171644.8 peroxisome proliferator activated receptor gamma, transcript variant 8 (from RefSeq NR_176971.1) ENSMUST00000171644.1 ENSMUST00000171644.2 ENSMUST00000171644.3 ENSMUST00000171644.4 ENSMUST00000171644.5 ENSMUST00000171644.6 ENSMUST00000171644.7 M1VPI1 M1VPI1_MOUSE NR_176971 PPARG Pparg uc009dis.1 uc009dis.2 uc009dis.3 uc009dis.4 uc009dis.5 Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. Heterodimer with other nuclear receptors. Cytoplasm Nucleus Belongs to the nuclear hormone receptor family. NR1 subfamily. DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding nucleus cytoplasm regulation of transcription, DNA-templated zinc ion binding intracellular receptor signaling pathway steroid hormone mediated signaling pathway sequence-specific DNA binding metal ion binding rhythmic process uc009dis.1 uc009dis.2 uc009dis.3 uc009dis.4 uc009dis.5 
ENSMUST00000171649.8 Bscl2 ENSMUST00000171649.8 BSCL2 lipid droplet biogenesis associated, seipin, transcript variant 2 (from RefSeq NM_008144.5) A0A0R4J225 A0A0R4J225_MOUSE Bscl2 ENSMUST00000171649.1 ENSMUST00000171649.2 ENSMUST00000171649.3 ENSMUST00000171649.4 ENSMUST00000171649.5 ENSMUST00000171649.6 ENSMUST00000171649.7 NM_008144 uc008gni.1 uc008gni.2 uc008gni.3 Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein membrane integral component of membrane lipid storage integral component of endoplasmic reticulum membrane lipid particle organization uc008gni.1 uc008gni.2 uc008gni.3 
ENSMUST00000171652.3 C2cd4b ENSMUST00000171652.3 C2 calcium-dependent domain containing 4B (from RefSeq NM_001081314.2) C2cd4b ENSMUST00000171652.1 ENSMUST00000171652.2 Fam148b NM_001081314 Q80XU5 Q80XU5_MOUSE uc009qmq.1 uc009qmq.2 uc009qmq.3 uc009qmq.4 regulation of vascular permeability involved in acute inflammatory response positive regulation of acute inflammatory response regulation of cell adhesion uc009qmq.1 uc009qmq.2 uc009qmq.3 uc009qmq.4 
ENSMUST00000171656.3 Or5k16 ENSMUST00000171656.3 olfactory receptor family 5 subfamily K member 16 (from RefSeq NM_001011662.2) ENSMUST00000171656.1 ENSMUST00000171656.2 F8VQ90 F8VQ90_MOUSE NM_001011662 Olfr180 Or5k16 uc007zoj.1 uc007zoj.2 uc007zoj.3 uc007zoj.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: CB173553.1, DR065591.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007zoj.1 uc007zoj.2 uc007zoj.3 uc007zoj.4 
ENSMUST00000171664.2 4930433I11Rik ENSMUST00000171664.2 RIKEN cDNA 4930433I11 gene (from RefSeq NM_207248.3) 4930433I11Rik B2RX47 B2RX47_MOUSE ENSMUST00000171664.1 NM_207248 uc009gli.1 uc009gli.2 uc009gli.3 uc009gli.4 molecular_function cellular_component biological_process uc009gli.1 uc009gli.2 uc009gli.3 uc009gli.4 
ENSMUST00000171665.2 Gm15494 ENSMUST00000171665.2 Gm15494 (from geneSymbol) ENSMUST00000171665.1 uc291kti.1 uc291kti.2 uc291kti.1 uc291kti.2 
ENSMUST00000171671.3 Vmn2r58 ENSMUST00000171671.3 vomeronasal 2, receptor 58 (from RefSeq NM_001105055.1) ENSMUST00000171671.1 ENSMUST00000171671.2 K7N6V2 K7N6V2_MOUSE NM_001105055 Vmn2r58 uc012fit.1 uc012fit.2 uc012fit.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012fit.1 uc012fit.2 uc012fit.3 
ENSMUST00000171678.9 Abhd14a ENSMUST00000171678.9 abhydrolase domain containing 14A, transcript variant 6 (from RefSeq NM_001374660.1) Abhd14a E9Q136 E9Q136_MOUSE ENSMUST00000171678.1 ENSMUST00000171678.2 ENSMUST00000171678.3 ENSMUST00000171678.4 ENSMUST00000171678.5 ENSMUST00000171678.6 ENSMUST00000171678.7 ENSMUST00000171678.8 NM_001374660 uc009rjq.1 uc009rjq.2 uc009rjq.3 uc009rjq.4 Cytoplasm Belongs to the AB hydrolase superfamily. ABHD14 family. uc009rjq.1 uc009rjq.2 uc009rjq.3 uc009rjq.4 
ENSMUST00000171686.9 Rpp40 ENSMUST00000171686.9 ribonuclease P 40 subunit, transcript variant 1 (from RefSeq NM_145938.5) ENSMUST00000171686.1 ENSMUST00000171686.2 ENSMUST00000171686.3 ENSMUST00000171686.4 ENSMUST00000171686.5 ENSMUST00000171686.6 ENSMUST00000171686.7 ENSMUST00000171686.8 NM_145938 Q8BX66 Q8R1F9 RPP40_MOUSE uc011yyj.1 uc011yyj.2 uc011yyj.3 Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Nucleus, nucleolus Sequence=AAH24607.1; Type=Erroneous initiation; Evidence=; Sequence=BAC33465.1; Type=Erroneous initiation; Evidence=; Sequence=EDL40907.1; Type=Erroneous initiation; Evidence=; tRNA 5'-leader removal ribonuclease P activity nucleus nucleolar ribonuclease P complex nucleolus rRNA processing tRNA processing hydrolase activity multimeric ribonuclease P complex ribonuclease P RNA binding RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc011yyj.1 uc011yyj.2 uc011yyj.3 
ENSMUST00000171688.9 Ang ENSMUST00000171688.9 angiogenin, ribonuclease, RNase A family, 5, transcript variant 2 (from RefSeq NM_001161731.3) Ang Ang1 ENSMUST00000171688.1 ENSMUST00000171688.2 ENSMUST00000171688.3 ENSMUST00000171688.4 ENSMUST00000171688.5 ENSMUST00000171688.6 ENSMUST00000171688.7 ENSMUST00000171688.8 NM_001161731 Q3TBG7 Q3TBG7_MOUSE uc007tml.1 uc007tml.2 uc007tml.3 uc007tml.4 This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009]. Cytoplasmic vesicle, secretory vesicle lumen Nucleus, nucleolus Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity hydrolase activity nucleic acid phosphodiester bond hydrolysis uc007tml.1 uc007tml.2 uc007tml.3 uc007tml.4 
ENSMUST00000171692.2 Serpine3 ENSMUST00000171692.2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 (from RefSeq NM_001199945.1) E9Q6A2 E9Q6A2_MOUSE ENSMUST00000171692.1 NM_001199945 Serpine3 uc007ugo.1 uc007ugo.2 Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular space negative regulation of endopeptidase activity uc007ugo.1 uc007ugo.2 
ENSMUST00000171696.8 Ttpal ENSMUST00000171696.8 tocopherol (alpha) transfer protein-like, transcript variant 2 (from RefSeq NM_181734.3) A6PW51 ENSMUST00000171696.1 ENSMUST00000171696.2 ENSMUST00000171696.3 ENSMUST00000171696.4 ENSMUST00000171696.5 ENSMUST00000171696.6 ENSMUST00000171696.7 NM_181734 Q3U0R3 Q7TS94 Q9D3D0 TTPAL_MOUSE uc008nte.1 uc008nte.2 uc008nte.3 May act as a protein that binds a hydrophobic ligand. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D3D0-1; Sequence=Displayed; Name=2; IsoId=Q9D3D0-2; Sequence=VSP_006032, VSP_006033; Sequence=BAC28381.1; Type=Erroneous initiation; Evidence=; Sequence=BAC30352.1; Type=Erroneous initiation; Evidence=; Sequence=BAC31654.1; Type=Erroneous initiation; Evidence=; Sequence=BAC38289.1; Type=Erroneous initiation; Evidence=; molecular_function biological_process uc008nte.1 uc008nte.2 uc008nte.3 
ENSMUST00000171719.8 Ccr2 ENSMUST00000171719.8 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q543S8) AK046579 Ccr2 ENSMUST00000171719.1 ENSMUST00000171719.2 ENSMUST00000171719.3 ENSMUST00000171719.4 ENSMUST00000171719.5 ENSMUST00000171719.6 ENSMUST00000171719.7 Q543S8 Q543S8_MOUSE uc009shc.1 uc009shc.2 uc009shc.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. blood vessel remodeling G-protein coupled receptor activity chemokine receptor activity cytoplasm plasma membrane chemotaxis inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane C-C chemokine receptor activity cytokine-mediated signaling pathway CCR2 chemokine receptor binding chemokine-mediated signaling pathway positive regulation of monocyte chemotaxis positive regulation of astrocyte chemotaxis uc009shc.1 uc009shc.2 uc009shc.3 
ENSMUST00000171737.3 Odc1 ENSMUST00000171737.3 ornithine decarboxylase, structural 1, transcript variant 1 (from RefSeq NM_013614.3) DCOR_MOUSE ENSMUST00000171737.1 ENSMUST00000171737.2 NM_013614 Odc P00860 Q61997 Q61998 Q6PB87 uc007ncv.1 uc007ncv.2 uc007ncv.3 Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Reaction=H(+) + L-ornithine = CO2 + putrescine; Xref=Rhea:RHEA:22964, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:46911, ChEBI:CHEBI:326268; EC=4.1.1.17; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Inhibited by antizymes (AZs) OAZ1, OAZ2 and OAZ3 in response to polyamine levels. AZs inhibit the assembly of the functional homodimer by binding to ODC monomers. Additionally, OAZ1 targets ODC monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers (PubMed:8106349, PubMed:10378276). Does not form a heterodimer with AZIN2 (PubMed:24967154). Expressed during testis development in the outer part of the seminiferous tubules. Belongs to the Orn/Lys/Arg decarboxylase class-II family. kidney development catalytic activity ornithine decarboxylase activity cytoplasm cytosol polyamine metabolic process polyamine biosynthetic process positive regulation of cell proliferation putrescine biosynthetic process response to virus lyase activity carboxy-lyase activity putrescine biosynthetic process from ornithine regulation of protein catabolic process protein homodimerization activity perinuclear region of cytoplasm uc007ncv.1 uc007ncv.2 uc007ncv.3 
ENSMUST00000171738.2 Slc25a53 ENSMUST00000171738.2 solute carrier family 25, member 53, transcript variant 2 (from RefSeq NM_001114179.1) E9PZF7 E9PZF7_MOUSE ENSMUST00000171738.1 Mcart6 NM_001114179 Slc25a53 uc012hpc.1 uc012hpc.2 uc012hpc.3 Membrane ; Multi- pass membrane protein Belongs to the mitochondrial carrier (TC 2.A.29) family. membrane integral component of membrane uc012hpc.1 uc012hpc.2 uc012hpc.3 
ENSMUST00000171741.3 Vmn2r102 ENSMUST00000171741.3 vomeronasal 2, receptor 102 (from RefSeq NM_001104564.1) ENSMUST00000171741.1 ENSMUST00000171741.2 L7N279 L7N279_MOUSE NM_001104564 Vmn2r102 uc009vbg.1 uc009vbg.2 uc009vbg.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vbg.1 uc009vbg.2 uc009vbg.3 
ENSMUST00000171745.2 Vmn1r160 ENSMUST00000171745.2 vomeronasal 1 receptor 160 (from RefSeq NM_001166724.1) E9Q346 E9Q346_MOUSE ENSMUST00000171745.1 NM_001166724 Vmn1r160 uc012fel.1 uc012fel.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fel.1 uc012fel.2 
ENSMUST00000171749.3 AU018091 ENSMUST00000171749.3 expressed sequence AU018091 (from RefSeq NM_001004153.2) AU018091 E9PWS4 E9PWS4_MOUSE ENSMUST00000171749.1 ENSMUST00000171749.2 NM_001004153 uc009euk.1 uc009euk.2 uc009euk.3 Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143, ChEBI:CHEBI:32682; Evidence=; Reaction=L-lysine(in) = L-lysine(out); Xref=Rhea:RHEA:70935, ChEBI:CHEBI:32551; Evidence=; Reaction=L-ornithine(in) = L-ornithine(out); Xref=Rhea:RHEA:71199, ChEBI:CHEBI:46911; Evidence=; Membrane ; Multi- pass membrane protein Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. L-ornithine transmembrane transporter activity amino acid transport arginine transmembrane transporter activity L-lysine transmembrane transporter activity membrane integral component of membrane transmembrane transporter activity transmembrane transport L-arginine import across plasma membrane L-ornithine transmembrane transport L-lysine transmembrane transport uc009euk.1 uc009euk.2 uc009euk.3 
ENSMUST00000171765.2 Proc ENSMUST00000171765.2 protein C, transcript variant 2 (from RefSeq NM_001042767.3) ENSMUST00000171765.1 NM_001042767 O35498 P33587 PROC_MOUSE Q91WN8 Q99PC6 uc008ejb.1 uc008ejb.2 uc008ejb.3 This gene encodes the vitamin K-dependent protein C, which plays a vital role in the anticoagulation pathway. The encoded protein undergoes proteolytic processing including activation by thrombin-thrombomodulin complex to form the anticoagulant serine protease that degrades activated coagulation factors. A complete lack of the encoded protein in mice results in severe perinatal consumptive coagulopathy in the brain and liver, resulting in death within 24 hours after birth. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]. Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Reaction=Degradation of blood coagulation factors Va and VIIIa.; EC=3.4.21.69; Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin. Secreted Golgi apparatus Endoplasmic reticulum Plasma; synthesized in the liver. The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Calcium also binds, with stronger affinity to another site, beyond the GLA domain. This GLA-independent binding site is necessary for the recognition of the thrombin-thrombomodulin complex. Belongs to the peptidase S1 family. liver development serine-type endopeptidase activity calcium ion binding extracellular region extracellular space endoplasmic reticulum Golgi apparatus proteolysis blood coagulation hemostasis peptidase activity serine-type peptidase activity hydrolase activity negative regulation of blood coagulation negative regulation of apoptotic process protein self-association regulation of circulating fibrinogen levels negative regulation of inflammatory response negative regulation of coagulation oligopeptidase activity positive regulation of establishment of endothelial barrier uc008ejb.1 uc008ejb.2 uc008ejb.3 
ENSMUST00000171768.2 Gm17090 ENSMUST00000171768.2 Gm17090 (from geneSymbol) ENSMUST00000171768.1 uc287kjx.1 uc287kjx.2 uc287kjx.1 uc287kjx.2 
ENSMUST00000171784.8 Gm3594 ENSMUST00000171784.8 Gm3594 (from geneSymbol) E9Q2A7 E9Q2A7_MOUSE ENSMUST00000171784.1 ENSMUST00000171784.2 ENSMUST00000171784.3 ENSMUST00000171784.4 ENSMUST00000171784.5 ENSMUST00000171784.6 ENSMUST00000171784.7 Gm3594 uc288qop.1 uc288qop.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qop.1 uc288qop.2 
ENSMUST00000171798.2 Garin4 ENSMUST00000171798.2 golgi associated RAB2 interactor family member 4 (from RefSeq NM_001109759.1) B7XG49 B7XG49_MOUSE ENSMUST00000171798.1 Fam71a GARI-L4 Garin4 NM_001109759 uc011wyr.1 uc011wyr.2 Belongs to the GARIN family. molecular_function biological_process uc011wyr.1 uc011wyr.2 
ENSMUST00000171799.4 Smim35 ENSMUST00000171799.4 small integral membrane protein 35 (from RefSeq NM_001198971.1) E9Q2Z6 ENSMUST00000171799.1 ENSMUST00000171799.2 ENSMUST00000171799.3 NM_001198971 SIM35_MOUSE Smim35 uc009pfm.1 uc009pfm.2 uc009pfm.3 uc009pfm.4 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009pfm.1 uc009pfm.2 uc009pfm.3 uc009pfm.4 
ENSMUST00000171802.8 Mcmdc2 ENSMUST00000171802.8 minichromosome maintenance domain containing 2 (from RefSeq NM_177722.3) D3YTV7 D6RHP3 E9Q956 ENSMUST00000171802.1 ENSMUST00000171802.2 ENSMUST00000171802.3 ENSMUST00000171802.4 ENSMUST00000171802.5 ENSMUST00000171802.6 ENSMUST00000171802.7 MCMD2_MOUSE NM_177722 Q8CD58 uc011wie.1 uc011wie.2 Plays an important role in meiotic recombination and associated DNA double-strand break repair. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q956-1; Sequence=Displayed; Name=2; IsoId=E9Q956-2; Sequence=VSP_042394, VSP_042395, VSP_042396; Predominantly expressed in the gonads and the brain. Not detected in the heart, lung, nor embryonic fibroblasts. Mutant mice are viable and show no overt phenotype. However, both males and females are sterile. Males fail to produce spermatozoa, and formation of primordial follicles is disrupted in females. DNA replication origin binding single-stranded DNA binding nucleus DNA repair cellular response to DNA damage stimulus synaptonemal complex assembly meiotic recombination nodule assembly spermatogenesis late meiotic recombination nodule assembly MCM complex oogenesis meiotic cell cycle double-strand break repair involved in meiotic recombination uc011wie.1 uc011wie.2 
ENSMUST00000171804.4 Slc15a5 ENSMUST00000171804.4 solute carrier family 15, member 5 (from RefSeq NM_177787.4) B2RUQ4 ENSMUST00000171804.1 ENSMUST00000171804.2 ENSMUST00000171804.3 NM_177787 Q8CBB2 S15A5_MOUSE uc012eva.1 uc012eva.2 Proton oligopeptide cotransporter. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CBB2-1; Sequence=Displayed; Name=2; IsoId=Q8CBB2-2; Sequence=VSP_033358; Belongs to the major facilitator superfamily. Proton- dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. protein transport symporter activity peptide:proton symporter activity peptide transport membrane integral component of membrane transmembrane transporter activity oligopeptide transmembrane transport oligopeptide transmembrane transporter activity transmembrane transport hydrogen ion transmembrane transport peptide transmembrane transporter activity uc012eva.1 uc012eva.2 
ENSMUST00000171805.2 ENSMUSG00000121752 ENSMUST00000171805.2 ENSMUSG00000121752 (from geneSymbol) AK041999 ENSMUST00000171805.1 uc290row.1 uc290row.2 uc290row.1 uc290row.2 
ENSMUST00000171808.8 Dbf4 ENSMUST00000171808.8 DBF4 zinc finger, transcript variant 1 (from RefSeq NM_013726.3) B7ZNS0 DBF4A_MOUSE Dbf4a ENSMUST00000171808.1 ENSMUST00000171808.2 ENSMUST00000171808.3 ENSMUST00000171808.4 ENSMUST00000171808.5 ENSMUST00000171808.6 ENSMUST00000171808.7 NM_013726 Q3TQP4 Q3V1K2 Q6NSQ1 Q9CXF2 Q9QZ41 uc008wkc.1 uc008wkc.2 uc008wkc.3 uc008wkc.4 Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role DNA in replication and cell proliferation. Required for progression of S phase. The complex CDC7- DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2, ORC4 and ORC6. Interacts (via IBM motifs) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9QZ41-1; Sequence=Displayed; Name=2; IsoId=Q9QZ41-2; Sequence=VSP_018205; Name=3; IsoId=Q9QZ41-3; Sequence=VSP_018206, VSP_018207; In a cell cycle-dependent manner. Induced at low level through G1. Increased during S phase and decreased at the end of S phase. Phosphorylation increases its interaction with PSIP1. Sequence=AAH69983.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; nucleic acid binding protein serine/threonine kinase activity nucleus DNA replication protein phosphorylation cell cycle traversing start control point of mitotic cell cycle zinc ion binding positive regulation of nuclear cell cycle DNA replication nuclear body Dbf4-dependent protein kinase complex protein serine/threonine kinase activator activity metal ion binding positive regulation of protein serine/threonine kinase activity regulation of cell cycle phase transition uc008wkc.1 uc008wkc.2 uc008wkc.3 uc008wkc.4 
ENSMUST00000171810.8 Gm3149 ENSMUST00000171810.8 Gm3149 (from geneSymbol) E9PW52 E9PW52_MOUSE ENSMUST00000171810.1 ENSMUST00000171810.2 ENSMUST00000171810.3 ENSMUST00000171810.4 ENSMUST00000171810.5 ENSMUST00000171810.6 ENSMUST00000171810.7 Gm3149 Gm3476 uc288qjj.1 uc288qjj.2 molecular_function cellular_component biological_process uc288qjj.1 uc288qjj.2 
ENSMUST00000171811.4 Vmn2r85 ENSMUST00000171811.4 vomeronasal 2, receptor 85 (from RefSeq NM_001102602.1) ENSMUST00000171811.1 ENSMUST00000171811.2 ENSMUST00000171811.3 G3UW56 G3UW56_MOUSE NM_001102602 Vmn2r85 uc009vac.1 uc009vac.2 uc009vac.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vac.1 uc009vac.2 uc009vac.3 
ENSMUST00000171813.4 Esp8 ENSMUST00000171813.4 exocrine gland secreted peptide 8 (from RefSeq NM_001177584.1) ENSMUST00000171813.1 ENSMUST00000171813.2 ENSMUST00000171813.3 Esp8 F7AMQ8 F7AMQ8_MOUSE NM_001177584 uc012ati.1 uc012ati.2 uc012ati.3 pheromone activity extracellular space biological_process uc012ati.1 uc012ati.2 uc012ati.3 
ENSMUST00000171841.3 Vmn2r17 ENSMUST00000171841.3 vomeronasal 2, receptor 17, transcript variant 1 (from RefSeq NM_001104628.1) E9PYF5 E9PYF5_MOUSE ENSMUST00000171841.1 ENSMUST00000171841.2 NM_001104628 Vmn2r17 uc009vdo.1 uc009vdo.2 uc009vdo.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vdo.1 uc009vdo.2 uc009vdo.3 
ENSMUST00000171866.8 Gm3127 ENSMUST00000171866.8 Gm3127 (from geneSymbol) E9Q9P5 E9Q9P5_MOUSE ENSMUST00000171866.1 ENSMUST00000171866.2 ENSMUST00000171866.3 ENSMUST00000171866.4 ENSMUST00000171866.5 ENSMUST00000171866.6 ENSMUST00000171866.7 Gm3127 uc288qjb.1 uc288qjb.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qjb.1 uc288qjb.2 
ENSMUST00000171887.4 Rhbg ENSMUST00000171887.4 Rhesus blood group-associated B glycoprotein (from RefSeq NM_021375.3) ENSMUST00000171887.1 ENSMUST00000171887.2 ENSMUST00000171887.3 NM_021375 Q8BUX5 Q9QXP1 RHBG_MOUSE uc008pui.1 uc008pui.2 uc008pui.3 Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the basolateral plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. May transport either NH4(+) or NH3 ammonia species predominantly mediating an electrogenic NH4(+) transport (PubMed:15353405, PubMed:16131648, PubMed:20592240, PubMed:27681563) (By similarity). May act as a CO2 channel providing for renal acid secretion (By similarity). Reaction=NH4(+)(in) = NH4(+)(out); Xref=Rhea:RHEA:28747, ChEBI:CHEBI:28938; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28748; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28749; Evidence= Reaction=methylamine(out) = methylamine(in); Xref=Rhea:RHEA:74391, ChEBI:CHEBI:59338; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74392; Evidence= Reaction=CO2(out) = CO2(in); Xref=Rhea:RHEA:74891, ChEBI:CHEBI:16526; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74892; Evidence=; Inhibited by amiloride. Kinetic parameters: KM=2.5 mM for methylamine ; KM=2 mM for methylamine ; Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane. Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Expressed in kidney by connecting segments and collecting tubules. Also expressed in liver by perivenous hepatocytes. Expressed in the forestomach and the fundus of the stomach. Expressed in duodenum, jejunum, ileum and colon at the level of villous (at protein level). Specifically expressed in kidney where it is restricted to the epithelial linings of the convoluted tubules and the loop of Henle. Also detected in ovary. Expressed by hepatocytes and dermal hair follicles and papillae. Detected in embryos at 15 dpc and 17 dpc. Expressed in kidney, skin and liver of 16.5 dpc embryos. N-glycosylated. Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. plasma membrane integral component of plasma membrane ammonium transmembrane transporter activity spectrin-associated cytoskeleton ammonium transport membrane integral component of membrane basolateral plasma membrane ankyrin binding cytoplasmic vesicle membrane cytoplasmic vesicle anchored component of plasma membrane transepithelial ammonium transport ammonium transmembrane transport uc008pui.1 uc008pui.2 uc008pui.3 
ENSMUST00000171898.3 Pate7 ENSMUST00000171898.3 prostate and testis expressed 7 (from RefSeq NM_001167673.1) E9Q4V7 E9Q4V7_MOUSE ENSMUST00000171898.1 ENSMUST00000171898.2 Gm17727 NM_001167673 Pate7 uc012gqo.1 uc012gqo.2 uc012gqo.1 uc012gqo.2 
ENSMUST00000171906.2 Gm3667 ENSMUST00000171906.2 predicted gene 3667, transcript variant 8 (from RefSeq NM_001374150.1) ENSMUST00000171906.1 Gm3667 K7N757 K7N757_MOUSE NM_001374150 uc288qpl.1 uc288qpl.2 uc288qpl.1 uc288qpl.2 
ENSMUST00000171914.3 Vmn2r101 ENSMUST00000171914.3 vomeronasal 2, receptor 101 (from RefSeq NM_001104563.1) E9PX04 E9PZS9 E9PZS9_MOUSE ENSMUST00000171914.1 ENSMUST00000171914.2 H3BL16 NM_001104563 Vmn2r101 uc009vbf.1 uc009vbf.2 uc009vbf.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vbf.1 uc009vbf.2 uc009vbf.3 
ENSMUST00000171923.8 Ulk4 ENSMUST00000171923.8 unc-51-like kinase 4 (from RefSeq NM_177589.3) E9Q2P5 E9Q2P5_MOUSE ENSMUST00000171923.1 ENSMUST00000171923.2 ENSMUST00000171923.3 ENSMUST00000171923.4 ENSMUST00000171923.5 ENSMUST00000171923.6 ENSMUST00000171923.7 NM_177589 Ulk4 uc012hco.1 uc012hco.2 uc012hco.3 microtubule cytoskeleton organization protein kinase activity ATP binding protein phosphorylation regulation of neuron projection development regulation of MAPK cascade regulation of JNK cascade regulation of protein kinase C signaling regulation of p38MAPK cascade regulation of neuron migration uc012hco.1 uc012hco.2 uc012hco.3 
ENSMUST00000171929.8 Cenpf ENSMUST00000171929.8 centromere protein F (from RefSeq NM_001081363.2) Cenpf E9Q3P4 E9Q3P4_MOUSE ENSMUST00000171929.1 ENSMUST00000171929.2 ENSMUST00000171929.3 ENSMUST00000171929.4 ENSMUST00000171929.5 ENSMUST00000171929.6 ENSMUST00000171929.7 NM_001081363 uc007eao.1 uc007eao.2 uc007eao.3 uc007eao.4 mitotic cell cycle chromosome, centromeric region spindle pole condensed chromosome outer kinetochore kidney development nucleus nuclear envelope nucleoplasm cytoplasm centrosome spindle axoneme chromosome segregation protein C-terminus binding transcription factor binding regulation of G2/M transition of mitotic cell cycle protein transport regulation of striated muscle tissue development nuclear matrix ventricular system development midbody ciliary basal body protein homodimerization activity pronucleus negative regulation of transcription, DNA-templated metaphase plate congression dynein complex binding ciliary transition fiber kinetochore uc007eao.1 uc007eao.2 uc007eao.3 uc007eao.4 
ENSMUST00000171933.8 Mtm1 ENSMUST00000171933.8 X-linked myotubular myopathy gene 1, transcript variant 1 (from RefSeq NM_001164190.2) ENSMUST00000171933.1 ENSMUST00000171933.2 ENSMUST00000171933.3 ENSMUST00000171933.4 ENSMUST00000171933.5 ENSMUST00000171933.6 ENSMUST00000171933.7 MTM1_MOUSE NM_001164190 Q5BKQ5 Q9Z2C5 uc012hjp.1 uc012hjp.2 Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology (By similarity). Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:12391329). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3- phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5- bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:39019, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57795, ChEBI:CHEBI:57923; EC=3.1.3.95; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3- phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol) + phosphate; Xref=Rhea:RHEA:42328, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:65221, ChEBI:CHEBI:78934; Evidence=; Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5- bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:45632, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:78911, ChEBI:CHEBI:85342; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5- phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo- inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:45636, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:78994, ChEBI:CHEBI:84968; Evidence=; Allosterically activated by phosphatidylinositol 5-phosphate (PI5P). Heterodimer with MTMR12 (PubMed:23818870). Interacts with KMT2A/MLL1 (via SET domain) (By similarity). Interacts with DES in skeletal muscle but not in cardiac muscle (PubMed:21135508). Interacts with SPEG (By similarity). Q9Z2C5; O08539: Bin1; NbExp=3; IntAct=EBI-6861578, EBI-775152; Q9Z2C5; P31001: Des; NbExp=4; IntAct=EBI-6861578, EBI-298565; Cytoplasm Cell membrane ; Peripheral membrane protein Cell projection, filopodium Cell projection, ruffle Late endosome Cytoplasm, myofibril, sarcomere Note=Localizes as a dense cytoplasmic network. Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles. Predominantly located in the cytoplasm following interaction with MTMR12. Recruited to the late endosome following EGF stimulation (By similarity). In skeletal muscles, co-localizes with MTMR12 in the sarcomere (PubMed:23818870). Widely expressed with highest levels detected in heart and muscle and low levels in brain (at protein level) (PubMed:12118066). Expressed in skeletal muscles (at protein level) (PubMed:23818870). Expression increases during skeletal muscle cell differentiation. The GRAM domain mediates binding to PI(3,5)P2 and, with lower affinity, to other phosphoinositides. Mice are viable although lifespan is severely reduced. An under-representation of mutant males suggests some prenatal lethality. Generalized and progressive myopathy starts at around 4 weeks of age with amyotrophy and accumulation of central nuclei in skeletal muscle fibers, leading to death at 6-14 weeks. Mutants also show mitochondrial disorganization and increased levels of desmin with abnormal desmin intermediate filament formation and architecture. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. ruffle phosphatidylinositol-3-phosphatase activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding cytoplasm endosome late endosome cytosol plasma membrane protein dephosphorylation lipid metabolic process endosome to lysosome transport protein transport membrane dephosphorylation hydrolase activity phosphatase activity intermediate filament binding sarcomere filopodium I band negative regulation of TOR signaling negative regulation of proteasomal ubiquitin-dependent protein catabolic process phosphatidylinositol binding peptidyl-tyrosine dephosphorylation cell projection regulation of vacuole organization intermediate filament organization muscle cell cellular homeostasis phosphatidylinositol dephosphorylation mitochondrion distribution positive regulation of skeletal muscle tissue growth negative regulation of protein kinase B signaling phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity mitochondrion morphogenesis negative regulation of autophagosome assembly uc012hjp.1 uc012hjp.2 
ENSMUST00000171938.2 Fignl1 ENSMUST00000171938.2 fidgetin-like 1, transcript variant 7 (from RefSeq NM_001425654.1) ENSMUST00000171938.1 FIGL1_MOUSE NM_001425654 Q3UF48 Q8BPY9 Q8C2I6 Q9ERZ5 uc007ias.1 uc007ias.2 uc007ias.3 Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:17352653). May play a role in the control of male meiosis dynamic (PubMed:22110678). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Hexamer. Interacts (via N-terminal one-half region) with RAD51; the interaction is direct. Interacts (via N-terminal one-half region) with SPIDR (via the C-terminal region); the interaction is direct (By similarity). Interacts with FIRRM; may regulate homologous recombination (By similarity). Nucleus Cytoplasm Cytoplasm, perinuclear region Note=Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage- induced foci after ionizing radiation (IR) treatment. Expressed at high level in the testis (PubMed:22110678). Detected in pachytene spermatocytes and in metaphase spermatocytes (at protein level). The N-terminus is necessary for its recruitment to DNA damage sites. Belongs to the AAA ATPase family. nucleotide binding nuclear chromosome magnesium ion binding osteoblast differentiation ATP binding nucleus cytoplasm male meiosis microtubule-severing ATPase activity regulation of double-strand break repair via homologous recombination hydrolase activity ATPase activity cytoplasmic microtubule organization osteoblast proliferation negative regulation of apoptotic process ATP metabolic process metal ion binding perinuclear region of cytoplasm microtubule severing regulation of cell cycle cellular response to ionizing radiation negative regulation of intrinsic apoptotic signaling pathway uc007ias.1 uc007ias.2 uc007ias.3 
ENSMUST00000171942.11 Vmn2r40 ENSMUST00000171942.11 vomeronasal 2, receptor 40 (from RefSeq NM_001105072.1) ENSMUST00000171942.1 ENSMUST00000171942.10 ENSMUST00000171942.2 ENSMUST00000171942.3 ENSMUST00000171942.4 ENSMUST00000171942.5 ENSMUST00000171942.6 ENSMUST00000171942.7 ENSMUST00000171942.8 ENSMUST00000171942.9 F6W043 F6W043_MOUSE NM_001105072 Vmn2r40 uc012eye.1 uc012eye.2 uc012eye.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012eye.1 uc012eye.2 uc012eye.3 
ENSMUST00000171964.8 Gm8297 ENSMUST00000171964.8 Gm8297 (from geneSymbol) ENSMUST00000171964.1 ENSMUST00000171964.2 ENSMUST00000171964.3 ENSMUST00000171964.4 ENSMUST00000171964.5 ENSMUST00000171964.6 ENSMUST00000171964.7 Gm8297 L7N287 L7N287_MOUSE uc288qle.1 uc288qle.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qle.1 uc288qle.2 
ENSMUST00000171970.3 Bmp6 ENSMUST00000171970.3 bone morphogenetic protein 6 (from RefSeq NM_007556.4) B2RRV6 BMP6_MOUSE Bmp-6 ENSMUST00000171970.1 ENSMUST00000171970.2 NM_007556 P20722 Vgr1 uc007qdp.1 uc007qdp.2 uc007qdp.3 uc007qdp.4 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Mice lacking this gene exhibit delayed ossification of the sternum, iron overload, and reduced fertility in females. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X80992.1, AK135770.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (By similarity). Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV (PubMed:19252486). Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3 (PubMed:31800957). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (By similarity). Interacts with SOSTDC1 (PubMed:14623234). Interacts (when glycosylated) with type I receptor ACVR1; the interaction may induce HAMP expression (PubMed:31800957). Interacts with type II receptor ACVR2B (By similarity). Interacts with Hemojuvelin/HJV (PubMed:19252486). Interacts with ERFE; the interaction inhibits BMP- induced transcription of HAMP (PubMed:30097509, PubMed:31800957). Interacts with BMPR1A/ALK3 (PubMed:31800957). Forms heterodimers with BMP2 in vitro; the heterodimer then binds to its receptor BMPR1A /ALK3 and may induce HAMP expression (PubMed:31800957). Secreted Expressed in the lung. Low levels seen in the kidney. Deficient mice are viable and fertile without displaying overt effects in tissues known to express BMP6, suggesting a functional redundancy among the factors of this subgroup (PubMed:9664685). However, these mice show a significant increased liver iron content (PubMed:19252486, PubMed:32464486). Belongs to the TGF-beta family. negative regulation of transcription from RNA polymerase II promoter ossification osteoblast differentiation eye development kidney development positive regulation of endothelial cell proliferation endochondral ossification type B pancreatic cell development cytokine activity transforming growth factor beta receptor binding protein binding extracellular region extracellular space cytoplasm cellular iron ion homeostasis inflammatory response immune response multicellular organism development growth factor activity response to iron ion positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation response to activity cell differentiation positive regulation of bone mineralization BMP signaling pathway male genitalia development positive regulation of lipopolysaccharide-mediated signaling pathway cellular response to extracellular stimulus vesicle response to magnesium ion positive regulation of chondrocyte differentiation positive regulation of aldosterone biosynthetic process response to retinoic acid regulation of apoptotic process positive regulation of vascular permeability regulation of MAPK cascade positive regulation of endothelial cell differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity cell development positive regulation of epithelial cell proliferation positive regulation of peptidyl-tyrosine phosphorylation cartilage development response to glucocorticoid positive regulation of SMAD protein import into nucleus SMAD protein signal transduction multicellular organismal iron ion homeostasis BMP receptor binding cellular response to mechanical stimulus cellular response to iron ion cellular response to BMP stimulus negative regulation of adherens junction organization negative regulation of cell-cell adhesion mediated by cadherin positive regulation of aldosterone secretion uc007qdp.1 uc007qdp.2 uc007qdp.3 uc007qdp.4 
ENSMUST00000171975.8 Arih1 ENSMUST00000171975.8 ariadne RBR E3 ubiquitin protein ligase 1 (from RefSeq NM_019927.2) ARI1_MOUSE Ari E9Q1X3 ENSMUST00000171975.1 ENSMUST00000171975.2 ENSMUST00000171975.3 ENSMUST00000171975.4 ENSMUST00000171975.5 ENSMUST00000171975.6 ENSMUST00000171975.7 NM_019927 Q6PF92 Q8CFJ4 Q9Z1K5 Ubch7bp Uip77 uc009pxs.1 uc009pxs.2 uc009pxs.3 uc009pxs.4 E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes. Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear. According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest. According to another report EIF4E2 ubiquitination leads to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2. In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, may act in nuclear subcellular localization and nuclear morphology. Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence=; Autoinhibited by the ariadne domain, which masks the second RING-type zinc finger that contains the active site and inhibits the E3 activity. Inhibition is relieved upon binding to neddylated cullin-RING ubiquitin ligase complexes, which activate the E3 ligase activity of ARIH1. Protein modification; protein ubiquitination. Interacts (via the first RING-type zinc finger) with UBE2L3. Associates with cullin-RING ubiquitin ligase (CRL) complexes containing CUL1, CUL2 and CUL3. Interacts with neddylated CUL1. Interacts with neddylated CUL2. Interacts with neddylated CUL3. Interacts with neddylated CUL4A. Cytoplasm Nucleus Nucleus, Cajal body Note=Mainly cytoplasmic. Present in Lewy body. Widely expressed. Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT- type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate. The Ariadne domain inhibits activity by masking the second RING-type zinc finger that contains the active site. Belongs to the RBR family. Ariadne subfamily. Sequence=AAH38034.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; ubiquitin ligase complex protein polyubiquitination ubiquitin-protein transferase activity nucleus cytoplasm ubiquitin-dependent protein catabolic process zinc ion binding Cajal body protein ubiquitination nuclear body transferase activity SCF ubiquitin ligase complex Cul2-RING ubiquitin ligase complex Cul3-RING ubiquitin ligase complex Cul4A-RING E3 ubiquitin ligase complex ubiquitin conjugating enzyme binding ubiquitin protein ligase binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity Lewy body uc009pxs.1 uc009pxs.2 uc009pxs.3 uc009pxs.4 
ENSMUST00000171996.3 Vmn2r117 ENSMUST00000171996.3 vomeronasal 2, receptor 117 (from RefSeq NM_001104581.1) ENSMUST00000171996.1 ENSMUST00000171996.2 K7N6V1 K7N6V1_MOUSE NM_001104581 Vmn2r117 uc009vbu.1 uc009vbu.2 uc009vbu.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vbu.1 uc009vbu.2 uc009vbu.3 
ENSMUST00000171999.9 Gcat ENSMUST00000171999.9 glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase), transcript variant 2 (from RefSeq NM_001161712.1) E9PWY6 E9PWY6_MOUSE ENSMUST00000171999.1 ENSMUST00000171999.2 ENSMUST00000171999.3 ENSMUST00000171999.4 ENSMUST00000171999.5 ENSMUST00000171999.6 ENSMUST00000171999.7 ENSMUST00000171999.8 Gcat NM_001161712 uc007wsf.1 uc007wsf.2 uc007wsf.3 uc007wsf.4 Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence= Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. catalytic activity threonine catabolic process glycine C-acetyltransferase activity biosynthetic process transferase activity pyridoxal phosphate binding uc007wsf.1 uc007wsf.2 uc007wsf.3 uc007wsf.4 
ENSMUST00000172000.3 Gm21992 ENSMUST00000172000.3 predicted gene 21992, transcript variant 1 (from RefSeq NM_001290127.1) ENSMUST00000172000.1 ENSMUST00000172000.2 F7BGR7 F7BGR7_MOUSE Gm21992 NM_001290127 uc289qdw.1 uc289qdw.2 This locus represents naturally occurring readthrough transcription between the neighboring Rbm14 (RNA binding motif protein 14) and Rbm4 (RNA binding motif protein 4) genes. Alternative splicing results in multiple transcript variants, some of which encode fusion proteins that share sequence identity with each individual gene product. A slight modification was made to the summary, since not all variants are protein coding [provided by RefSeq, Jun 2018]. nucleic acid binding RNA binding zinc ion binding uc289qdw.1 uc289qdw.2 
ENSMUST00000172002.8 Gng13 ENSMUST00000172002.8 guanine nucleotide binding protein (G protein), gamma 13, transcript variant 1 (from RefSeq NM_022422.5) ENSMUST00000172002.1 ENSMUST00000172002.2 ENSMUST00000172002.3 ENSMUST00000172002.4 ENSMUST00000172002.5 ENSMUST00000172002.6 ENSMUST00000172002.7 GBG13_MOUSE NM_022422 Q9JMF3 uc008bbi.1 uc008bbi.2 uc008bbi.3 uc008bbi.4 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units, alpha, beta and gamma. Cell membrane ; Lipid-anchor ; Cytoplasmic side Belongs to the G protein gamma family. GTPase activity heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway membrane dendrite G-protein beta-subunit binding sensory perception of taste uc008bbi.1 uc008bbi.2 uc008bbi.3 uc008bbi.4 
ENSMUST00000172025.3 Zfp968-ps ENSMUST00000172025.3 Zfp968-ps (from geneSymbol) BC032262 ENSMUST00000172025.1 ENSMUST00000172025.2 F7CJN1 F7CJN1_MOUSE Gm14440 Zfp968-ps uc290ded.1 uc290ded.2 uc290ded.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process uc290ded.1 uc290ded.2 uc290ded.3 
ENSMUST00000172026.8 Tshb ENSMUST00000172026.8 thyroid stimulating hormone, beta subunit, transcript variant 2 (from RefSeq NM_001165939.1) E9Q4F3 E9Q4F3_MOUSE ENSMUST00000172026.1 ENSMUST00000172026.2 ENSMUST00000172026.3 ENSMUST00000172026.4 ENSMUST00000172026.5 ENSMUST00000172026.6 ENSMUST00000172026.7 NM_001165939 Tshb uc012cva.1 uc012cva.2 Indispensable for the control of thyroid structure and metabolism. Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin. Secreted Belongs to the glycoprotein hormones subunit beta family. hormone activity extracellular region signal transduction response to vitamin A response to estrogen response to calcium ion uc012cva.1 uc012cva.2 
ENSMUST00000172032.4 Ces2h ENSMUST00000172032.4 carboxylesterase 2H (from RefSeq NM_001272045.2) Ces2h ENSMUST00000172032.1 ENSMUST00000172032.2 ENSMUST00000172032.3 F6Z9B9 F6Z9B9_MOUSE NM_001272045 uc033jhg.1 uc033jhg.2 uc033jhg.3 Belongs to the type-B carboxylesterase/lipase family. extracellular space prostaglandin metabolic process response to organic substance hydrolase activity carboxylic ester hydrolase activity uc033jhg.1 uc033jhg.2 uc033jhg.3 
ENSMUST00000172035.8 Gemin5 ENSMUST00000172035.8 gem nuclear organelle associated protein 5, transcript variant 1 (from RefSeq NM_001166669.1) E9PUU4 E9PUU4_MOUSE ENSMUST00000172035.1 ENSMUST00000172035.2 ENSMUST00000172035.3 ENSMUST00000172035.4 ENSMUST00000172035.5 ENSMUST00000172035.6 ENSMUST00000172035.7 Gemin5 NM_001166669 uc007jal.1 uc007jal.2 uc007jal.3 uc007jal.4 RNA 7-methylguanosine cap binding spliceosomal snRNP assembly mRNA 3'-UTR binding nucleoplasm cytoplasm cytosol regulation of translation nuclear body snRNA binding U1 snRNA binding U4 snRNA binding U4atac snRNA binding SMN complex SMN-Gemin2 complex SMN-Sm protein complex ribosome binding uc007jal.1 uc007jal.2 uc007jal.3 uc007jal.4 
ENSMUST00000172037.2 Gm17096 ENSMUST00000172037.2 Gm17096 (from geneSymbol) ENSMUST00000172037.1 uc290crg.1 uc290crg.2 uc290crg.1 uc290crg.2 
ENSMUST00000172097.9 Spaca6 ENSMUST00000172097.9 sperm acrosome associated 6 (from RefSeq NM_001162909.1) B7ZWC7 D3Z1S3 E9Q8Q8 ENSMUST00000172097.1 ENSMUST00000172097.2 ENSMUST00000172097.3 ENSMUST00000172097.4 ENSMUST00000172097.5 ENSMUST00000172097.6 ENSMUST00000172097.7 ENSMUST00000172097.8 J3QMI7 NM_001162909 SACA6_MOUSE Spaca6 uc012alg.1 uc012alg.2 uc012alg.3 Sperm protein required for fusion of sperm with the egg membrane during fertilization. Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=E9Q8Q8-1; Sequence=Displayed; Name=2; IsoId=E9Q8Q8-2; Sequence=VSP_057873, VSP_057874; Name=3; IsoId=E9Q8Q8-3; Sequence=VSP_057872, VSP_057875, VSP_057876; Highly expressed in testis (PubMed:24275887, PubMed:32393636). Minor expression also detected in epididymis, seminal vesicle and ovary (PubMed:32393636). Predominantly expressed in testicular germ cells during spermiogenesis (PubMed:24275887). Most abundant in round spermatids and detected at lower levels in elongating spermatids (PubMed:24275887). Expression is first detected on postnatal day 21. Male infertility (PubMed:24275887, PubMed:32393636). Testis appearance, size and weight are normal and there is no effect on sperm morphology or motility but there is a failure of sperm-egg interaction and fusion (PubMed:24275887, PubMed:32393636). Spermatozoa undergo normal acrosomal reaction and can penetrate the zona pellucida but accumulate in the perivitelline space as they are unable to fuse with the egg plasma membrane to complete fertilization (PubMed:24275887, PubMed:32393636). No effect on amount or localization of sperm-egg fusion protein IZUMO1 (PubMed:32393636). Belongs to the SPACA6 family. molecular_function fusion of sperm to egg plasma membrane membrane integral component of membrane uc012alg.1 uc012alg.2 uc012alg.3 
ENSMUST00000172106.9 Speer1a ENSMUST00000172106.9 spermatogenesis associated glutamate (E)-rich protein 1A, transcript variant 1 (from RefSeq NM_001309520.2) ENSMUST00000172106.1 ENSMUST00000172106.2 ENSMUST00000172106.3 ENSMUST00000172106.4 ENSMUST00000172106.5 ENSMUST00000172106.6 ENSMUST00000172106.7 ENSMUST00000172106.8 F6X687 F6X687_MOUSE NM_001309520 Speer1 uc057btd.1 uc057btd.2 uc057btd.3 uc057btd.1 uc057btd.2 uc057btd.3 
ENSMUST00000172107.8 St13 ENSMUST00000172107.8 suppression of tumorigenicity 13, transcript variant 1 (from RefSeq NM_133726.3) ENSMUST00000172107.1 ENSMUST00000172107.2 ENSMUST00000172107.3 ENSMUST00000172107.4 ENSMUST00000172107.5 ENSMUST00000172107.6 ENSMUST00000172107.7 F10A1_MOUSE Fam10a1 Hip NM_133726 Q4FJT4 Q99L47 uc007wwl.1 uc007wwl.2 uc007wwl.3 One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the C-terminus 302- 318 AA) with GRK5 (By similarity). Cytoplasm Belongs to the FAM10 family. cytoplasm cytosol response to bacterium protein domain specific binding Hsp70 protein binding dATP binding macromolecular complex identical protein binding macromolecular complex binding protein dimerization activity unfolded protein binding chaperone mediated protein folding requiring cofactor chaperone binding protein homooligomerization protein homotetramerization negative regulation of protein refolding uc007wwl.1 uc007wwl.2 uc007wwl.3 
ENSMUST00000172117.2 Gm17175 ENSMUST00000172117.2 Gm17175 (from geneSymbol) E9Q528 E9Q528_MOUSE ENSMUST00000172117.1 Gm17175 uc288tpo.1 uc288tpo.2 uc288tpo.1 uc288tpo.2 
ENSMUST00000172128.2 Gm17234 ENSMUST00000172128.2 Gm17234 (from geneSymbol) ENSMUST00000172128.1 uc287ihi.1 uc287ihi.2 uc287ihi.1 uc287ihi.2 
ENSMUST00000172132.10 Tpi1 ENSMUST00000172132.10 triosephosphate isomerase 1 (from RefSeq NM_009415.3) ENSMUST00000172132.1 ENSMUST00000172132.2 ENSMUST00000172132.3 ENSMUST00000172132.4 ENSMUST00000172132.5 ENSMUST00000172132.6 ENSMUST00000172132.7 ENSMUST00000172132.8 ENSMUST00000172132.9 NM_009415 P17751 Q3TJH2 Q3UC04 Q3UKG9 Q64513 Q9CVF9 Q9CWE7 TPIS_MOUSE Tpi uc012esp.1 uc012esp.2 uc012esp.3 Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. Reaction=dihydroxyacetone phosphate = methylglyoxal + phosphate; Xref=Rhea:RHEA:17937, ChEBI:CHEBI:17158, ChEBI:CHEBI:43474, ChEBI:CHEBI:57642; EC=4.2.3.3; Evidence=; Reaction=D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate; Xref=Rhea:RHEA:18585, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=5.3.1.1; Evidence=; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate from glycerone phosphate: step 1/1. Carbohydrate biosynthesis; gluconeogenesis. Homodimer. Cytoplasm Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=P17751-1; Sequence=Displayed; Name=2; IsoId=P17751-2; Sequence=VSP_060724; Belongs to the triosephosphate isomerase family. catalytic activity triose-phosphate isomerase activity cytoplasm cytosol glucose metabolic process gluconeogenesis glycolytic process multicellular organism development methylglyoxal synthase activity lyase activity isomerase activity methylglyoxal biosynthetic process glycerol catabolic process glyceraldehyde-3-phosphate metabolic process ubiquitin protein ligase binding protein homodimerization activity glyceraldehyde-3-phosphate biosynthetic process uc012esp.1 uc012esp.2 uc012esp.3 
ENSMUST00000172136.9 Pwwp2b ENSMUST00000172136.9 PWWP domain containing 2B, transcript variant 1 (from RefSeq NM_001098636.1) E9Q9M8 ENSMUST00000172136.1 ENSMUST00000172136.2 ENSMUST00000172136.3 ENSMUST00000172136.4 ENSMUST00000172136.5 ENSMUST00000172136.6 ENSMUST00000172136.7 ENSMUST00000172136.8 NM_001098636 PWP2B_MOUSE Pwwp2 uc009kfo.1 uc009kfo.2 uc009kfo.3 Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin- modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (By similarity). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (PubMed:30228260). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (PubMed:34180153). Component of a MTA1-specific subcomplex of the NuRD complex composed of PWWP2B, MTA1 and HDAC1 but does not contain CHD4 and MBD3 (By similarity). Interacts with MTA1, MTA2, MTA3, HDAC1, HDAC2, RBBP4, RBBP7, BRCC3 and ZNF516 (PubMed:34180153). Does not interact with CHD4 and MBD3 (By similarity). Nucleus Expressed in the brown adipose tissue. Induced in response to cold. Deubiquitinated by BRCC3; leading to its stabilization. molecular_function nucleoplasm biological_process uc009kfo.1 uc009kfo.2 uc009kfo.3 
ENSMUST00000172140.3 Vmn2r8 ENSMUST00000172140.3 vomeronasal 2, receptor 8 (from RefSeq NM_001104620.1) ENSMUST00000172140.1 ENSMUST00000172140.2 L7N472 L7N472_MOUSE NM_001104620 Vmn2r8 uc009vdf.1 uc009vdf.2 uc009vdf.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vdf.1 uc009vdf.2 uc009vdf.3 
ENSMUST00000172142.8 Nisch ENSMUST00000172142.8 nischarin, transcript variant 2 (from RefSeq NM_001347583.1) ENSMUST00000172142.1 ENSMUST00000172142.2 ENSMUST00000172142.3 ENSMUST00000172142.4 ENSMUST00000172142.5 ENSMUST00000172142.6 ENSMUST00000172142.7 Kiaa0975 NISCH_MOUSE NM_001347583 Q2YDV7 Q80TM9 Q8C354 Q8C4X9 Q8CBH0 Q91XW6 Q99LG6 Q9EPW8 Q9WUM6 uc007sxa.1 uc007sxa.2 uc007sxa.3 uc007sxa.4 Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell- signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation. Inhibits Rac- induced cell migration and invasion in breast and colon epithelial cells. Inhibits lamellipodia formation, when overexpressed. Plays a role in protection against apoptosis (By similarity). Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3 (By similarity). When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures (By similarity). Homooligomer (By similarity). Interacts with GRB2 (By similarity). Interacts with PIK3R1; probably associates with the PI3- kinase complex (By similarity). Interacts with IRS4 (By similarity). Found in a complex with ITGA5 and PAK1. Found in a complex with LIMK1 and PAK1. Interacts with ITGA5 (via cytoplasmic domain); this interaction is direct. Interacts with PAK1 (via kinase domain); this interaction is direct and is increased upon activation of PAK1. Interacts with LIMK1 (via PDZ and kinase domain); this interaction is direct. Interacts with LIMK2; this interaction depends on LIMK2 activity. Interacts with RAC1 (activated state). Interacts with STK11; this interaction may increase STK11 activity (By similarity). Cell membrane Cytoplasm rly endosome Recycling endosome Note=Enriched in the early/sorting and recycling endosomes (By similarity). Colocalized in early/sorting endosomes with EEA1 and SNX2 and in recycling endosomes with transferrin receptor (By similarity). Colocalized with MAPK1 and MAPK3 in RVLM neurons (By similarity). Detected in the perinuclear region partially associated with punctate structures. Colocalizes with PAK1 in cytoplasm, vesicular structures in the perinuclear area and membrane ruffles. Colocalizes with RAC1 in the cytoplasm and vesicles structures. Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q80TM9-1; Sequence=Displayed; Name=2; IsoId=Q80TM9-2; Sequence=VSP_035141; Name=3; IsoId=Q80TM9-3; Sequence=VSP_035136; Name=4; IsoId=Q80TM9-4; Sequence=VSP_035142, VSP_035143; Name=5; IsoId=Q80TM9-5; Sequence=VSP_035139, VSP_035140; Name=6; IsoId=Q80TM9-6; Sequence=VSP_035144, VSP_035145; Name=7; IsoId=Q80TM9-7; Sequence=VSP_035137, VSP_035138; Highly expressed in brain and kidney. Moderately expressed in heart, liver, lung and skeletal muscle. Not detected in spleen and testis. Expressed in embryo at 7 day dpc onwards. Both the presence of the PX domain and the coiled coil region are necessary for its endosomal targeting. 'Nischarin' means 'slowness of motion' in classic Sanskrit. Sequence=AAH03270.1; Type=Erroneous initiation; Evidence=; Sequence=AAI08365.1; Type=Frameshift; Evidence=; Sequence=AAK52087.1; Type=Erroneous initiation; Evidence=; Sequence=BAC65694.1; Type=Erroneous initiation; Evidence=; integrin binding cytoplasm endosome early endosome cytosol plasma membrane glucose metabolic process apoptotic process regulation of blood pressure membrane Rac protein signal transduction protein kinase binding actin cytoskeleton organization negative regulation of cell migration regulation of synaptic transmission, GABAergic phosphatidylinositol binding identical protein binding norepinephrine secretion recycling endosome uc007sxa.1 uc007sxa.2 uc007sxa.3 uc007sxa.4 
ENSMUST00000172148.5 Mc5r ENSMUST00000172148.5 melanocortin 5 receptor (from RefSeq NM_013596.3) ENSMUST00000172148.1 ENSMUST00000172148.2 ENSMUST00000172148.3 ENSMUST00000172148.4 MC5R_MOUSE NM_013596 P41149 uc008fnl.1 uc008fnl.2 uc008fnl.3 uc008fnl.4 uc008fnl.5 Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. Cell membrane; Multi-pass membrane protein. Skin, adrenal gland, skeletal muscle, bone marrow, spleen, thymus, gonads, uterus and brain. Belongs to the G-protein coupled receptor 1 family. Sequence=AAA76585.1; Type=Erroneous initiation; Evidence=; G-protein coupled receptor activity melanocortin receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway membrane integral component of membrane hormone binding uc008fnl.1 uc008fnl.2 uc008fnl.3 uc008fnl.4 uc008fnl.5 
ENSMUST00000172155.2 Mageb11 ENSMUST00000172155.2 MAGE family member B11 (from RefSeq NM_001101450.1) ENSMUST00000172155.1 G3UW88 G3UW88_MOUSE Gm44 Mageb11 NM_001101450 uc012hls.1 uc012hls.2 molecular_function cellular_component biological_process uc012hls.1 uc012hls.2 
ENSMUST00000172163.2 Gm8011 ENSMUST00000172163.2 Gm8011 (from geneSymbol) ENSMUST00000172163.1 Gm8011 K7N6Y5 K7N6Y5_MOUSE uc288spq.1 uc288spq.2 uc288spq.1 uc288spq.2 
ENSMUST00000172164.10 Slc7a4 ENSMUST00000172164.10 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4, transcript variant 2 (from RefSeq NM_144852.3) CTR4_MOUSE ENSMUST00000172164.1 ENSMUST00000172164.2 ENSMUST00000172164.3 ENSMUST00000172164.4 ENSMUST00000172164.5 ENSMUST00000172164.6 ENSMUST00000172164.7 ENSMUST00000172164.8 ENSMUST00000172164.9 NM_144852 Q8BLQ7 uc007ylk.1 uc007ylk.2 uc007ylk.3 Involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Membrane ; Multi-pass membrane protein Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. amino acid transport membrane integral component of membrane transmembrane transporter activity transmembrane transport uc007ylk.1 uc007ylk.2 uc007ylk.3 
ENSMUST00000172175.3 Zbtb3 ENSMUST00000172175.3 zinc finger and BTB domain containing 3, transcript variant 2 (from RefSeq NM_133759.4) ENSMUST00000172175.1 ENSMUST00000172175.2 NM_133759 Q3UQP3 Q8BIJ4 Q91X45 ZBTB3_MOUSE uc008gnc.1 uc008gnc.2 uc008gnc.3 May be involved in transcriptional regulation. Nucleus Sequence=AAH12410.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleic acid binding DNA binding nucleus cellular response to DNA damage stimulus metal ion binding uc008gnc.1 uc008gnc.2 uc008gnc.3 
ENSMUST00000172178.2 A230065N10Rik ENSMUST00000172178.2 A230065N10Rik (from geneSymbol) AK038819 ENSMUST00000172178.1 uc291smh.1 uc291smh.2 uc291smh.1 uc291smh.2 
ENSMUST00000172184.2 Serpinb6c ENSMUST00000172184.2 serine (or cysteine) peptidase inhibitor, clade B, member 6c, transcript variant 1 (from RefSeq NM_148942.3) ENSMUST00000172184.1 NM_148942 Serpinb6c W4VSP4 W4VSP4_MOUSE uc007qan.1 uc007qan.2 uc007qan.3 Belongs to the serpin family. serine-type endopeptidase inhibitor activity extracellular space cytoplasm negative regulation of endopeptidase activity uc007qan.1 uc007qan.2 uc007qan.3 
ENSMUST00000172190.4 Vmn2r94 ENSMUST00000172190.4 vomeronasal 2, receptor 94 (from RefSeq NM_001104543.2) E9PZK8 E9PZK8_MOUSE ENSMUST00000172190.1 ENSMUST00000172190.2 ENSMUST00000172190.3 NM_001104543 Vmn2r94 uc009vax.1 uc009vax.2 uc009vax.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vax.1 uc009vax.2 uc009vax.3 
ENSMUST00000172191.3 Apol11a ENSMUST00000172191.3 apolipoprotein L 11a (from RefSeq NM_001177533.2) Apol11a E9PZG0 E9PZG0_MOUSE ENSMUST00000172191.1 ENSMUST00000172191.2 NM_001177533 uc011zvh.1 uc011zvh.2 uc011zvh.3 Belongs to the apolipoprotein L family. cellular_component extracellular region lipid transport biological_process lipid binding lipoprotein metabolic process uc011zvh.1 uc011zvh.2 uc011zvh.3 
ENSMUST00000172199.3 Vmn2r20 ENSMUST00000172199.3 vomeronasal 2, receptor 20 (from RefSeq NM_001104634.1) ENSMUST00000172199.1 ENSMUST00000172199.2 L7N2B1 L7N2B1_MOUSE NM_001104634 Vmn2r20 uc009vdv.1 uc009vdv.2 uc009vdv.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vdv.1 uc009vdv.2 uc009vdv.3 
ENSMUST00000172202.2 Gm17300 ENSMUST00000172202.2 Gm17300 (from geneSymbol) AK133170 ENSMUST00000172202.1 uc290qlh.1 uc290qlh.2 uc290qlh.1 uc290qlh.2 
ENSMUST00000172203.2 Vmn2r103 ENSMUST00000172203.2 vomeronasal 2, receptor 103 (from RefSeq NM_001104565.1) E9PWW0 E9PWW0_MOUSE ENSMUST00000172203.1 NM_001104565 Vmn2r103 uc009vbh.1 uc009vbh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vbh.1 uc009vbh.2 
ENSMUST00000172205.5 Krtap10-29 ENSMUST00000172205.5 predicted gene 9639 (from RefSeq NM_001370824.1) A0A1W2P739 A0A1W2P739_MOUSE ENSMUST00000172205.1 ENSMUST00000172205.2 ENSMUST00000172205.3 ENSMUST00000172205.4 Gm9639 NM_001370824 uc287smp.1 uc287smp.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc287smp.1 uc287smp.2 
ENSMUST00000172211.2 Gm17180 ENSMUST00000172211.2 Gm17180 (from geneSymbol) ENSMUST00000172211.1 uc290dil.1 uc290dil.2 uc290dil.1 uc290dil.2 
ENSMUST00000172251.2 Igflr1 ENSMUST00000172251.2 Igflr1 (from geneSymbol) BC019733 E9Q0U5 E9Q0U5_MOUSE ENSMUST00000172251.1 Igflr1 Tmem149 uc012fhs.1 uc012fhs.2 uc012fhs.3 membrane integral component of membrane uc012fhs.1 uc012fhs.2 uc012fhs.3 
ENSMUST00000172257.2 Or13d1 ENSMUST00000172257.2 olfactory receptor family 13 subfamily D member 1 (from RefSeq NM_146607.2) ENSMUST00000172257.1 NM_146607 Olfr270 Or13d1 Q8VFN0 Q8VFN0_MOUSE uc008swr.1 uc008swr.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC127971.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008swr.1 uc008swr.2 
ENSMUST00000172278.8 Chrm2 ENSMUST00000172278.8 cholinergic receptor, muscarinic 2, cardiac, transcript variant 1 (from RefSeq NM_203491.4) ACM2_MOUSE Chrm-2 E9Q9P0 ENSMUST00000172278.1 ENSMUST00000172278.2 ENSMUST00000172278.3 ENSMUST00000172278.4 ENSMUST00000172278.5 ENSMUST00000172278.6 ENSMUST00000172278.7 NM_203491 Q9ERZ4 uc009biy.1 uc009biy.2 uc009biy.3 uc009biy.4 The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol (By similarity). Interacts with ARRB1 and ARRB2. Interacts with RACK1; the interaction regulates CHRM2 internalization (By similarity). Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi- pass membrane protein Note=Phosphorylation in response to agonist binding promotes receptor internalization. Phosphorylated in response to agonist treatment. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily. G-protein coupled receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane regulation of smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway G-protein coupled acetylcholine receptor signaling pathway chemical synaptic transmission regulation of heart contraction response to virus membrane integral component of membrane G-protein coupled acetylcholine receptor activity cell junction dendrite neurotransmitter receptor activity asymmetric synapse symmetric synapse neuronal cell body axon terminus synapse postsynaptic membrane glutamatergic synapse cholinergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane arrestin family protein binding regulation of synaptic vesicle exocytosis uc009biy.1 uc009biy.2 uc009biy.3 uc009biy.4 
ENSMUST00000172282.8 Ptbp1 ENSMUST00000172282.8 polypyrimidine tract binding protein 1, transcript variant 9 (from RefSeq NR_176355.1) ENSMUST00000172282.1 ENSMUST00000172282.2 ENSMUST00000172282.3 ENSMUST00000172282.4 ENSMUST00000172282.5 ENSMUST00000172282.6 ENSMUST00000172282.7 NR_176355 P17225 PTBP1_MOUSE Ptb Q8BGJ5 Q922I7 uc007gab.1 uc007gab.2 uc007gab.3 uc007gab.4 Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre- mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre- mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Monomer. Part of a ternary complex containing KHSRP, PTBP1, PTBP2 and HNRPH1. Interacts with SFPQ (By similarity). Interacts with RAVER1. Nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P17225-1; Sequence=Displayed; Name=2; IsoId=P17225-2; Sequence=VSP_061654; Expressed in myoblast; expression gradually decreases during muscle cell differentiation (at protein level). The C-terminal 195 amino acids of PTB are sufficient for specific RNA binding. Sequence=CAA36321.1; Type=Frameshift; Evidence=; single-stranded DNA endodeoxyribonuclease activity regulation of alternative mRNA splicing, via spliceosome nuclear-transcribed mRNA catabolic process regulatory region RNA binding nucleic acid binding single-stranded DNA binding RNA binding mRNA binding protein binding nucleus cytoplasm DNA metabolic process mRNA processing RNA splicing positive regulation of neuron projection development positive regulation of insulin secretion negative regulation of RNA splicing positive regulation of protein dephosphorylation pre-mRNA binding sequence-specific DNA binding neuron projection terminus negative regulation of neuron differentiation positive regulation of translation positive regulation of transcription from RNA polymerase II promoter negative regulation of mRNA splicing, via spliceosome negative regulation of muscle cell differentiation positive regulation of calcineurin-NFAT signaling cascade 3'-UTR-mediated mRNA stabilization IRES-dependent viral translational initiation positive regulation of secretory granule organization uc007gab.1 uc007gab.2 uc007gab.3 uc007gab.4 
ENSMUST00000172288.3 Dennd2c ENSMUST00000172288.3 DENN domain containing 2C, transcript variant 1 (from RefSeq NM_177857.2) Dennd2c E9Q4E4 E9Q4E4_MOUSE ENSMUST00000172288.1 ENSMUST00000172288.2 NM_177857 uc008qsq.1 uc008qsq.2 uc008qsq.3 Rab guanyl-nucleotide exchange factor activity uc008qsq.1 uc008qsq.2 uc008qsq.3 
ENSMUST00000172298.8 Rab11a ENSMUST00000172298.8 RAB11A, member RAS oncogene family (from RefSeq NM_017382.5) ENSMUST00000172298.1 ENSMUST00000172298.2 ENSMUST00000172298.3 ENSMUST00000172298.4 ENSMUST00000172298.5 ENSMUST00000172298.6 ENSMUST00000172298.7 NM_017382 Q0PD45 Q0PD45_MOUSE Rab11A Rab11a uc009qce.1 uc009qce.2 uc009qce.3 Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Cell membrane ; Lipid-anchor Cleavage furrow Cytoplasmic vesicle membrane Cytoplasmic vesicle, phagosome Endosome membrane ; Lipid-anchor Golgi apparatus, trans-Golgi network Membrane ; Lipid-anchor Recycling endosome membrane ; Lipid-anchor Belongs to the small GTPase superfamily. Rab family. spindle pole GTPase activity GTP binding multivesicular body trans-Golgi network centrosome microtubule organizing center kinetochore microtubule mitotic metaphase plate congression microtubule binding positive regulation of epithelial cell migration regulation of multivesicular body size positive regulation of G2/M transition of mitotic cell cycle vesicle-mediated transport transport vesicle astral microtubule organization neuron projection development cytoplasmic vesicle myosin V binding vesicle cleavage furrow regulation of cytokinesis macromolecular complex multivesicular body assembly intracellular membrane-bounded organelle phagocytic vesicle regulation of long-term neuronal synaptic plasticity regulation of protein transport establishment of vesicle localization recycling endosome regulation of vesicle-mediated transport extracellular exosome establishment of protein localization to organelle protein localization to plasma membrane establishment of protein localization to membrane mitotic spindle assembly postsynaptic recycling endosome neurotransmitter receptor transport, endosome to postsynaptic membrane glutamatergic synapse vesicle-mediated transport in synapse positive regulation of protein localization to plasma membrane exosomal secretion uc009qce.1 uc009qce.2 uc009qce.3 
ENSMUST00000172299.2 Rnf152 ENSMUST00000172299.2 ring finger protein 152, transcript variant 2 (from RefSeq NM_001160368.1) ENSMUST00000172299.1 NM_001160368 Q0VF67 Q8BG47 RN152_MOUSE Rnf152 uc011wpz.1 uc011wpz.2 E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB (PubMed:25936802). Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling (PubMed:25936802). Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition (By similarity). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation (By similarity). Induces apoptosis when overexpressed (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with RRAGA (inactive GDP-bound form); stimulated by amino acid starvation (By similarity). Interacts with SEC16A (PubMed:29300766). Lysosome membrane ; Single-pass membrane protein Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome. Mice lacking Rnf152 do not show overt embryonic development defect. Belongs to the RNF152 family. protein polyubiquitination ubiquitin-protein transferase activity protein binding lysosome lysosomal membrane apoptotic process positive regulation of autophagy membrane integral component of membrane protein ubiquitination transferase activity small GTPase binding integral component of organelle membrane cellular response to amino acid starvation metal ion binding ubiquitin protein ligase activity protein K63-linked ubiquitination protein K48-linked ubiquitination negative regulation of TORC1 signaling uc011wpz.1 uc011wpz.2 
ENSMUST00000172304.9 ENSMUSG00000121462 ENSMUST00000172304.9 testis specific protein-Y encoded, pseudogene (from RefSeq NR_027507.1) ENSMUST00000172304.1 ENSMUST00000172304.2 ENSMUST00000172304.3 ENSMUST00000172304.4 ENSMUST00000172304.5 ENSMUST00000172304.6 ENSMUST00000172304.7 ENSMUST00000172304.8 NR_027507 uc009uze.1 uc009uze.2 uc009uze.3 uc009uze.1 uc009uze.2 uc009uze.3 
ENSMUST00000172306.3 Dusp7 ENSMUST00000172306.3 dual specificity phosphatase 7 (from RefSeq NM_153459.4) DUS7_MOUSE Dusp7 E9PVF4 E9QMS8 ENSMUST00000172306.1 ENSMUST00000172306.2 NM_153459 Q3USH2 Q91Z46 uc009rjm.1 uc009rjm.2 uc009rjm.3 uc009rjm.4 Dual specificity protein phosphatase (PubMed:27783954). Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption (PubMed:27783954). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (PubMed:27783954). May also inactivate PRKCA and/or PRKCG (PubMed:27783954). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (PubMed:27783954). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Strongly inhibited by sodium orthovanadate. Interacts with MAPK1/ERK2; the interaction enhances DUSP7 phosphatase activity. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91Z46-1; Sequence=Displayed; Name=2; IsoId=Q91Z46-2; Sequence=VSP_041462; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. Sequence=BAE24360.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; inactivation of MAPK activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytoplasm cytosol protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity peptidyl-tyrosine dephosphorylation negative regulation of MAP kinase activity uc009rjm.1 uc009rjm.2 uc009rjm.3 uc009rjm.4 
ENSMUST00000172314.9 Hbp1 ENSMUST00000172314.9 high mobility group box transcription factor 1, transcript variant 1 (from RefSeq NM_153198.3) E9Q1A8 E9Q1A8_MOUSE ENSMUST00000172314.1 ENSMUST00000172314.2 ENSMUST00000172314.3 ENSMUST00000172314.4 ENSMUST00000172314.5 ENSMUST00000172314.6 ENSMUST00000172314.7 ENSMUST00000172314.8 Hbp1 NM_153198 uc007nhu.1 uc007nhu.2 uc007nhu.3 uc007nhu.4 Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'- TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. Nucleus DNA binding RNA binding nucleus nucleoplasm regulation of transcription, DNA-templated nuclear speck uc007nhu.1 uc007nhu.2 uc007nhu.3 uc007nhu.4 
ENSMUST00000172322.2 Vmn1r118 ENSMUST00000172322.2 vomeronasal 1 receptor 118 (from RefSeq NM_001166742.1) ENSMUST00000172322.1 L7N273 L7N273_MOUSE NM_001166742 Vmn1r118 uc012fcs.1 uc012fcs.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fcs.1 uc012fcs.2 
ENSMUST00000172332.4 Ccdc71l ENSMUST00000172332.4 coiled-coil domain containing 71 like (from RefSeq NM_001162903.1) 2010109K11Rik Ccdc71l E9Q4T4 E9Q4T4_MOUSE ENSMUST00000172332.1 ENSMUST00000172332.2 ENSMUST00000172332.3 NM_001162903 uc007nie.1 uc007nie.2 uc007nie.3 uc007nie.4 molecular_function cellular_component biological_process uc007nie.1 uc007nie.2 uc007nie.3 uc007nie.4 
ENSMUST00000172338.4 Vmn2r71 ENSMUST00000172338.4 vomeronasal 2, receptor 71 (from RefSeq NM_001384948.1) ENSMUST00000172338.1 ENSMUST00000172338.2 ENSMUST00000172338.3 L7N2D8 L7N2D8_MOUSE NM_001384948 Vmn2r71 uc012fol.1 uc012fol.2 uc012fol.3 uc012fol.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012fol.1 uc012fol.2 uc012fol.3 uc012fol.4 
ENSMUST00000172359.3 Vmn2r91 ENSMUST00000172359.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q2U5) E9Q2U5 E9Q2U5_MOUSE ENSMUST00000172359.1 ENSMUST00000172359.2 Vmn2r91 uc009vav.1 uc009vav.2 uc009vav.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vav.1 uc009vav.2 uc009vav.3 
ENSMUST00000172361.8 Hnrnpd ENSMUST00000172361.8 heterogeneous nuclear ribonucleoprotein D, transcript variant 1 (from RefSeq NM_001077265.2) Auf1 ENSMUST00000172361.1 ENSMUST00000172361.2 ENSMUST00000172361.3 ENSMUST00000172361.4 ENSMUST00000172361.5 ENSMUST00000172361.6 ENSMUST00000172361.7 HNRPD_MOUSE Hnrpd NM_001077265 Q60667 Q60668 Q80ZJ0 Q91X94 uc008ygt.1 uc008ygt.2 uc008ygt.3 Binds with high affinity to RNA molecules that contain AU- rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR and SYNCRIP. Interacts with IGF2BP2. Interacts with GTPBP1. Interacts with EIF4G1; the interaction requires RNA. Interacts with EIF3B and RPS3. Q60668; P06151: Ldha; NbExp=2; IntAct=EBI-299932, EBI-444940; Nucleus Cytoplasm Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q60668-1; Sequence=Displayed; Name=2; IsoId=Q60668-2; Sequence=VSP_007940; Name=3; Synonyms=muAUF1-3; IsoId=Q60668-3; Sequence=VSP_007941; Name=4; IsoId=Q60668-4; Sequence=VSP_007940, VSP_007941; Methylated by PRMT1, in an insulin-dependent manner. The PRMT1- mediated methylation regulates its phosphorylation (By similarity). Arg-345 is dimethylated, probably to asymmetric dimethylarginine. Sequence=AAA64653.1; Type=Frameshift; Evidence=; Sequence=AAA64653.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence=; Sequence=AAA64654.1; Type=Frameshift; Evidence=; Sequence=AAA64654.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence=; liver development nucleic acid binding DNA binding AT DNA binding chromatin binding RNA binding mRNA binding protein binding nucleus nucleoplasm cytoplasm cytosol brain development transcription factor binding positive regulation of gene expression negative regulation of gene expression cerebellum development regulation of telomere maintenance response to estradiol mRNA 3'-UTR AU-rich region binding telomeric DNA binding regulation of circadian rhythm mRNA transcription from RNA polymerase II promoter histone deacetylase binding regulation of mRNA stability sequence-specific DNA binding synapse positive regulation of translation mRNA stabilization rhythmic process response to calcium ion response to electrical stimulus 3'-UTR-mediated mRNA destabilization cellular response to amino acid stimulus cellular response to estradiol stimulus cellular response to nitric oxide circadian regulation of translation response to rapamycin positive regulation of telomere capping response to sodium phosphate cellular response to putrescine positive regulation of telomerase RNA reverse transcriptase activity hepatocyte dedifferentiation sequence-specific double-stranded DNA binding ribonucleoprotein complex uc008ygt.1 uc008ygt.2 uc008ygt.3 
ENSMUST00000172367.3 Gm42421 ENSMUST00000172367.3 Gm42421 (from geneSymbol) BC110684 ENSMUST00000172367.1 ENSMUST00000172367.2 uc291bos.1 uc291bos.2 uc291bos.1 uc291bos.2 
ENSMUST00000172387.8 Mrpl13 ENSMUST00000172387.8 mitochondrial ribosomal protein L13 (from RefSeq NM_026759.3) ENSMUST00000172387.1 ENSMUST00000172387.2 ENSMUST00000172387.3 ENSMUST00000172387.4 ENSMUST00000172387.5 ENSMUST00000172387.6 ENSMUST00000172387.7 NM_026759 Q9D1P0 RM13_MOUSE uc007vsf.1 uc007vsf.2 uc007vsf.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity). Interacts with OXA1L (By similarity). Mitochondrion Belongs to the universal ribosomal protein uL13 family. mRNA binding structural constituent of ribosome mitochondrion mitochondrial ribosome mitochondrial large ribosomal subunit ribosome translation negative regulation of translation uc007vsf.1 uc007vsf.2 uc007vsf.3 
ENSMUST00000172391.4 Vmn2r23 ENSMUST00000172391.4 vomeronasal 2, receptor 23 (from RefSeq NM_001104638.1) E9PXI5 E9PXI5_MOUSE ENSMUST00000172391.1 ENSMUST00000172391.2 ENSMUST00000172391.3 NM_001104638 Vmn2r23 uc009vdy.1 uc009vdy.2 uc009vdy.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc009vdy.1 uc009vdy.2 uc009vdy.3 
ENSMUST00000172396.8 Ddx39a ENSMUST00000172396.8 Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus (By similarity). (from UniProt Q8VDW0) AK137114 DX39A_MOUSE Ddx39 Ddx39a ENSMUST00000172396.1 ENSMUST00000172396.2 ENSMUST00000172396.3 ENSMUST00000172396.4 ENSMUST00000172396.5 ENSMUST00000172396.6 ENSMUST00000172396.7 Q3UJV4 Q8C2C2 Q8VDW0 uc292blg.1 uc292blg.2 Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Binds ALYREF/THOC4 and DDX39B/BAT1 (By similarity). Interacts with SARNP (By similarity). Interacts with MX1 (By similarity). Interacts with MCM3AP (By similarity). Nucleus Cytoplasm Note=Can translocate to the cytoplasm in the presence of MX1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VDW0-1; Sequence=Displayed; Name=2; IsoId=Q8VDW0-2; Sequence=VSP_013064; Belongs to the DEAD box helicase family. DECD subfamily. nucleotide binding transcription export complex mRNA splicing, via spliceosome nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus cytoplasm mRNA processing mRNA export from nucleus RNA splicing nuclear speck hydrolase activity ATPase activity identical protein binding uc292blg.1 uc292blg.2 
ENSMUST00000172403.9 Pla2g6 ENSMUST00000172403.9 phospholipase A2, group VI, transcript variant 14 (from RefSeq NM_001416400.1) ENSMUST00000172403.1 ENSMUST00000172403.2 ENSMUST00000172403.3 ENSMUST00000172403.4 ENSMUST00000172403.5 ENSMUST00000172403.6 ENSMUST00000172403.7 ENSMUST00000172403.8 NM_001416400 Pla2g6 Q3UN31 Q3UN31_MOUSE uc007wtg.1 uc007wtg.2 uc007wtg.3 uc007wtg.4 Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; lipid metabolic process lipid catabolic process hydrolase activity uc007wtg.1 uc007wtg.2 uc007wtg.3 uc007wtg.4 
ENSMUST00000172431.8 Gm3512 ENSMUST00000172431.8 Gm3512 (from geneSymbol) AK017182 E9Q032 E9Q032_MOUSE ENSMUST00000172431.1 ENSMUST00000172431.2 ENSMUST00000172431.3 ENSMUST00000172431.4 ENSMUST00000172431.5 ENSMUST00000172431.6 ENSMUST00000172431.7 Gm3512 uc288qpx.1 uc288qpx.2 molecular_function cellular_component biological_process uc288qpx.1 uc288qpx.2 
ENSMUST00000172435.8 Fndc4 ENSMUST00000172435.8 fibronectin type III domain containing 4, transcript variant 2 (from RefSeq NM_022424.7) ENSMUST00000172435.1 ENSMUST00000172435.2 ENSMUST00000172435.3 ENSMUST00000172435.4 ENSMUST00000172435.5 ENSMUST00000172435.6 ENSMUST00000172435.7 FNDC4_MOUSE Fnmp1 Frcp1 NM_022424 Q3TR08 Q810E5 Q9CYY4 uc008wyd.1 uc008wyd.2 uc008wyd.3 uc008wyd.4 Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to down-regulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by down-regulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. Membrane ; Single-pass type I membrane protein Secreted Note=The N-terminus is probably cleaved to release a secreted extracellular portion of the protein. Highly expressed in adult liver and brain tissues. During embryo development, expressed in the brain. Up-regulated in the context of tissue inflammation. Therapeutic delivery of FNDC4 reduces the disease severity of chemical-induced colitis in mice. Sequence=AAO85424.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function extracellular region extracellular space endoplasmic reticulum plasma membrane membrane integral component of membrane negative regulation of inflammatory response response to transforming growth factor beta uc008wyd.1 uc008wyd.2 uc008wyd.3 uc008wyd.4 
ENSMUST00000172450.3 Pafah1b2 ENSMUST00000172450.3 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2, transcript variant 5 (from RefSeq NM_008775.3) ENSMUST00000172450.1 ENSMUST00000172450.2 NM_008775 PA1B2_MOUSE Pafah1b2 Pafahb Q61206 Q6PKE6 Q7TNP3 uc009pgx.1 uc009pgx.2 uc009pgx.3 Alpha2 catalytic subunit of the cytosolic type I platelet- activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3- phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2- acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (PubMed:12775763). Reaction=a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O- alkyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:17777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707; EC=3.1.1.47; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17778; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1- O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:40479, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:44811, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40480; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-O- hexadecyl-sn-glycero-3-phosphate + acetate + H(+); Xref=Rhea:RHEA:41704, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:77580, ChEBI:CHEBI:78385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41705; Evidence=; Reaction=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+); Xref=Rhea:RHEA:41708, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:78387, ChEBI:CHEBI:78390; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41709; Evidence=; Beta subunit (PAFAH1B1) stimulates the acetylhydrolase activity of the alpha2/alpha2 catalytic homodimer. Forms a catalytic dimer which is either homodimer (alpha2/alpha2 homodimer) or heterodimer with PAFAH1B3 (alpha2/alpha1 heterodimer). Component of the cytosolic (PAF-AH (I)) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity (By similarity). Interacts (homodimer form) with PAFAH1B1 (homodimer form); PAFAH1B2 competes with NDEL1 for PAFAH1B1 binding (By similarity). Interacts with VLDLR; this interaction may modulate the Reelin pathway (PubMed:17330141). Q61206; O35685: Nudc; NbExp=2; IntAct=EBI-7445518, EBI-911192; Cytoplasm. Expressed already by the time of neurulation. By 10.5 dpc, expression is abundant in the developing central and peripheral nervous systems. Major sites include the neuroepithelium of the fore-, mid-, and hindbrain, the spinal cord, the dorsal root, and cranial ganglia. Knockout mice which are homozygous for the PAFAH1B2 gene appear developmentally normal, and are born at the expected Mendelian rate (PubMed:12775763). Females bred normally, whereas male are infertile, and spermatogenesis is disrupted at mid- or late pachytene stages of meiosis or early spermiogenesis (PubMed:12775763). Double mutant female mice which are homozygous for PAFAH1B2 and PAFAH1B3 are grossly normal and fertile, whereas double- mutant males are infertile. Double mutan mice manifest an earlier disturbance of spermatogenesis with an onset at preleptotene or leptotene stages of meiosis (PubMed:12775763). Originally the subunits of the type I platelet- activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity). Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily. fibrillar center 1-alkyl-2-acetylglycerophosphocholine esterase activity protein binding nucleolus cytoplasm cytosol plasma membrane lipid metabolic process spermatogenesis brain development lipid catabolic process positive regulation of macroautophagy hydrolase activity protein homodimerization activity protein heterodimerization activity platelet-activating factor acetyltransferase activity uc009pgx.1 uc009pgx.2 uc009pgx.3 
ENSMUST00000172483.3 Lncob1 ENSMUST00000172483.3 Lncob1 (from geneSymbol) AK007000 ENSMUST00000172483.1 ENSMUST00000172483.2 uc291mmk.1 uc291mmk.2 uc291mmk.3 uc291mmk.1 uc291mmk.2 uc291mmk.3 
ENSMUST00000172500.3 4930488B22Rik ENSMUST00000172500.3 RIKEN cDNA 4930488B22 gene (from RefSeq NR_040627.1) ENSMUST00000172500.1 ENSMUST00000172500.2 NR_040627 uc029qvc.1 uc029qvc.2 uc029qvc.3 uc029qvc.1 uc029qvc.2 uc029qvc.3 
ENSMUST00000172518.8 Polr1h ENSMUST00000172518.8 RNA polymerase I subunit H, transcript variant 2 (from RefSeq NM_001355422.1) ENSMUST00000172518.1 ENSMUST00000172518.2 ENSMUST00000172518.3 ENSMUST00000172518.4 ENSMUST00000172518.5 ENSMUST00000172518.6 ENSMUST00000172518.7 NM_001355422 Polr1h Q791N7 RPA12_MOUSE Rpa12 Znrd1 uc008clp.1 uc008clp.2 uc008clp.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits. Nucleus, nucleolus Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. nucleic acid binding DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm nucleolus DNA-directed RNA polymerase I complex transcription, DNA-templated termination of RNA polymerase I transcription mRNA cleavage zinc ion binding metal ion binding RNA polymerase I activity uc008clp.1 uc008clp.2 uc008clp.3 
ENSMUST00000172526.5 BC051226 ENSMUST00000172526.5 BC051226 (from geneSymbol) ENSMUST00000172526.1 ENSMUST00000172526.2 ENSMUST00000172526.3 ENSMUST00000172526.4 KY467782 uc008bzz.1 uc008bzz.2 uc008bzz.3 uc008bzz.4 uc008bzz.5 uc008bzz.6 uc008bzz.1 uc008bzz.2 uc008bzz.3 uc008bzz.4 uc008bzz.5 uc008bzz.6 
ENSMUST00000172530.8 Adgb ENSMUST00000172530.8 androglobin (from RefSeq NM_001127353.4) ADGB_MOUSE Capn7l ENSMUST00000172530.1 ENSMUST00000172530.2 ENSMUST00000172530.3 ENSMUST00000172530.4 ENSMUST00000172530.5 ENSMUST00000172530.6 ENSMUST00000172530.7 G3UZ78 NM_001127353 Q8C5C7 uc287pmv.1 uc287pmv.2 Required for sperm flagellum formation and maturation of elongating spermatids, thus playing an essential role in male fertility (PubMed:35700329). Contributes to in vitro proteolytic cleavage of SEPT10 in a calmodulin-dependent manner (PubMed:35700329). Interacts with septin SEPT10. Cell projection, cilium, flagellum Note=Expressed within the midpiece and along the whole sperm flagellum (PubMed:35700329). Detected in the annulus of the sperm flagellum in S12 and S15 spermatids and mature sperm (PubMed:35700329). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=G3UZ78-1; Sequence=Displayed; Name=2; IsoId=G3UZ78-2; Sequence=VSP_042575, VSP_042576, VSP_042577, VSP_042578; Strongly expressed in testis and lung. Weakly expressed in heart, brain, spleen, kidney and tongue. In the postnatal testis, reaches a peak of expression at postnatal days 26-28 (at protein level) (PubMed:35700329). Expression is undetectable until postnatal day 21 corresponding to the 142 stage of round spermatids (PubMed:35700329). Male infertility, reduced testis weight, impaired maturation of elongating spermatids, abnormal sperm shape and ultrastructural defects in microtubule and mitochondrial organization (PubMed:35700329). Epididymal sperm display multiple flagellar malformations including coiled, bifid or shortened flagella, and erratic acrosomal development (PubMed:35700329). Mislocalization of Sept10 in sperm (PubMed:35700329). Females display no fertility issues (PubMed:35700329). Belongs to the peptidase C2 family. Lacks the conserved active site residues. Probably catalytically inactive. calcium-dependent cysteine-type endopeptidase activity proteolysis oxygen binding heme binding uc287pmv.1 uc287pmv.2 
ENSMUST00000172551.2 Vmn1r253 ENSMUST00000172551.2 vomeronasal 1 receptor 253 (from RefSeq NM_001167159.1) ENSMUST00000172551.1 Gm4133 Gm4187 K9J7G6 K9J7G6_MOUSE NM_001167159 Vmn1r243 Vmn1r253 uc012fdw.1 uc012fdw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fdw.1 uc012fdw.2 
ENSMUST00000172557.2 Pabpn1 ENSMUST00000172557.2 Cytoplasm Nucleus (from UniProt G3UWS5) AK032172 ENSMUST00000172557.1 G3UWS5 G3UWS5_MOUSE Pabpn1 uc288uis.1 uc288uis.2 Cytoplasm Nucleus nucleic acid binding RNA binding positive regulation of polynucleotide adenylyltransferase activity uc288uis.1 uc288uis.2 
ENSMUST00000172559.2 Mrgpra2b ENSMUST00000172559.2 Membrane ; Multi- pass membrane protein (from UniProt K4DID7) AY042192 ENSMUST00000172559.1 K4DID7 K4DID7_MOUSE Mgrg4 Mrgpra2b uc291qee.1 uc291qee.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc291qee.1 uc291qee.2 
ENSMUST00000172579.4 Zfp998 ENSMUST00000172579.4 zinc finger protein 998, transcript variant 1 (from RefSeq NM_001290196.2) 2410141K09Rik ENSMUST00000172579.1 ENSMUST00000172579.2 ENSMUST00000172579.3 K7N769 K7N769_MOUSE NM_001290196 Zfp998 uc056yub.1 uc056yub.2 uc056yub.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc056yub.1 uc056yub.2 uc056yub.3 
ENSMUST00000172582.5 Or10al6 ENSMUST00000172582.5 olfactory receptor family 10 subfamily AL member 6 (from RefSeq NM_146288.3) ENSMUST00000172582.1 ENSMUST00000172582.2 ENSMUST00000172582.3 ENSMUST00000172582.4 NM_146288 Olfr122 Or10al6 Q7TRJ3 Q7TRJ3_MOUSE uc029thq.1 uc029thq.2 uc029thq.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: CB173933.1, CB174318.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc029thq.1 uc029thq.2 uc029thq.3 
ENSMUST00000172588.2 Gm20536 ENSMUST00000172588.2 Gm20536 (from geneSymbol) ENSMUST00000172588.1 uc291fvs.1 uc291fvs.2 uc291fvs.1 uc291fvs.2 
ENSMUST00000172591.4 Gm20492 ENSMUST00000172591.4 Gm20492 (from geneSymbol) ENSMUST00000172591.1 ENSMUST00000172591.2 ENSMUST00000172591.3 uc287vmu.1 uc287vmu.2 uc287vmu.3 uc287vmu.4 uc287vmu.1 uc287vmu.2 uc287vmu.3 uc287vmu.4 
ENSMUST00000172602.9 Fam161a ENSMUST00000172602.9 family with sequence similarity 161, member A, transcript variant 47 (from RefSeq NR_176667.1) A0A991D8A3 A0A991D8A3_MOUSE ENSMUST00000172602.1 ENSMUST00000172602.2 ENSMUST00000172602.3 ENSMUST00000172602.4 ENSMUST00000172602.5 ENSMUST00000172602.6 ENSMUST00000172602.7 ENSMUST00000172602.8 Fam161a NR_176667 uc007ieq.1 uc007ieq.2 uc007ieq.3 uc007ieq.4 uc007ieq.5 Involved in ciliogenesis. Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Belongs to the FAM161 family. uc007ieq.1 uc007ieq.2 uc007ieq.3 uc007ieq.4 uc007ieq.5 
ENSMUST00000172646.8 Zic4 ENSMUST00000172646.8 zinc finger protein of the cerebellum 4, transcript variant 2 (from RefSeq NM_009576.3) ENSMUST00000172646.1 ENSMUST00000172646.2 ENSMUST00000172646.3 ENSMUST00000172646.4 ENSMUST00000172646.5 ENSMUST00000172646.6 ENSMUST00000172646.7 G3UYE7 G3UYE7_MOUSE NM_009576 Zic4 uc009rai.1 uc009rai.2 uc009rai.3 Belongs to the GLI C2H2-type zinc-finger protein family. nucleic acid binding uc009rai.1 uc009rai.2 uc009rai.3 
ENSMUST00000172699.2 Mex3a ENSMUST00000172699.2 mex3 RNA binding family member A (from RefSeq NM_001029890.3) ENSMUST00000172699.1 G3UYU0 G3UYU0_MOUSE Mex3a NM_001029890 uc012crx.1 uc012crx.2 uc012crx.3 Cytoplasm Nucleus nucleic acid binding RNA binding cytosol biological_process uc012crx.1 uc012crx.2 uc012crx.3 
ENSMUST00000172701.8 Wt1os ENSMUST00000172701.8 WT1 transcription factor, opposite strand (from RefSeq NR_015462.1) ENSMUST00000172701.1 ENSMUST00000172701.2 ENSMUST00000172701.3 ENSMUST00000172701.4 ENSMUST00000172701.5 ENSMUST00000172701.6 ENSMUST00000172701.7 NR_015462 uc008lkn.1 uc008lkn.2 uc008lkn.3 uc008lkn.1 uc008lkn.2 uc008lkn.3 
ENSMUST00000172710.8 Miip ENSMUST00000172710.8 Miip (from geneSymbol) C0KL25 C0KL25_MOUSE ENSMUST00000172710.1 ENSMUST00000172710.2 ENSMUST00000172710.3 ENSMUST00000172710.4 ENSMUST00000172710.5 ENSMUST00000172710.6 ENSMUST00000172710.7 FJ618908 IIP45 Miip uc290rsx.1 uc290rsx.2 negative regulation of G2/M transition of mitotic cell cycle negative regulation of cell migration uc290rsx.1 uc290rsx.2 
ENSMUST00000172714.3 Guk1 ENSMUST00000172714.3 guanylate kinase 1, transcript variant 6 (from RefSeq NM_001403836.1) ENSMUST00000172714.1 ENSMUST00000172714.2 Gmk Guk1 KGUA_MOUSE NM_001403836 Q564F2 Q564G0 Q64520 uc287ymh.1 uc287ymh.2 uc287ymh.3 Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:8663313). Involved in the cGMP metabolism in photoreceptors (By similarity). Reaction=ATP + GMP = ADP + GDP; Xref=Rhea:RHEA:20780, ChEBI:CHEBI:30616, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189, ChEBI:CHEBI:456216; EC=2.7.4.8; Evidence=; Monomer (By similarity). Interacts with RD3 (By similarity). Photoreceptor inner segment Cytoplasm, cytosol Note=Colocalizes with RD3 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q64520-1; Sequence=Displayed; Name=2; IsoId=Q64520-2; Sequence=VSP_060370; Widely expressed (PubMed:8663313). In retina is expressed in inner segment, outer nuclear layer, outer plexiform layer, inner plexiform layer, and ganglion cell layer (at protein level) (PubMed:29515371). Belongs to the guanylate kinase family. nucleotide binding guanylate kinase activity ATP binding cytosol purine nucleotide metabolic process dGDP biosynthetic process kinase activity phosphorylation transferase activity GDP-mannose metabolic process glycoprotein transport ATP metabolic process GMP metabolic process dGMP metabolic process dATP metabolic process GDP biosynthetic process nucleotide phosphorylation uc287ymh.1 uc287ymh.2 uc287ymh.3 
ENSMUST00000172721.2 Gm3211 ENSMUST00000172721.2 Gm3211 (from geneSymbol) ENSMUST00000172721.1 uc292jcn.1 uc292jcn.2 uc292jcn.1 uc292jcn.2 
ENSMUST00000172729.2 Gm44574 ENSMUST00000172729.2 Gm44574 (from geneSymbol) AK136625 ENSMUST00000172729.1 uc290zna.1 uc290zna.2 uc290zna.1 uc290zna.2 
ENSMUST00000172753.2 Hspa1b ENSMUST00000172753.2 heat shock protein 1B (from RefSeq NM_010478.2) ENSMUST00000172753.1 HS71B_MOUSE Hcp70.1 Hsp70-1 Hsp70a1 Hspa1 NM_010478 P17879 Q61689 Q925V6 uc008ceo.1 uc008ceo.2 uc008ceo.3 Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co- chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone- mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation. Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle. Enhances STUB1- mediated SMAD3 ubiquitination and degradation and facilitates STUB1- mediated inhibition of TGF-beta signaling. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. May be an auxiliary component of the CatSper complex (PubMed:17478420, PubMed:19516020). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2 (By similarity). Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed (By similarity). Interacts with TRIM5 (via B30.2/SPRY domain) (By similarity). Interacts with METTL21A (By similarity). Interacts with PRKN (By similarity). Interacts with FOXP3 (PubMed:23973223). Interacts with NOD2; the interaction enhances NOD2 stability (By similarity). Interacts with DNAJC9 (via J domain) (By similarity). Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes. Interacts with NAA10, HSP40, HSP90 and HDAC4. The acetylated form and the non- acetylated form interact with HOPX and STUB1 respectively. Interacts with NEDD1 and SMAD3. Interacts (via NBD) with BAG1, BAG2, BAG3 and HSPH1/HSP105. Interacts with DNAJC8 (By similarity). P17879; P28301: Lox; NbExp=2; IntAct=EBI-397360, EBI-642911; P17879; P70196: Traf6; NbExp=3; IntAct=EBI-397360, EBI-448028; Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Testis-specific. The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide- binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins. In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress. Belongs to the heat shock protein 70 family. nucleotide binding zona pellucida receptor complex protein binding ATP binding nucleus cytoplasm mitochondrion mitochondrial matrix centrosome microtubule organizing center cytosol cytoskeleton plasma membrane protein folding response to unfolded protein binding of sperm to zona pellucida response to heat vesicle-mediated transport ATPase activity heat shock protein binding ubiquitin protein ligase binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process macromolecular complex cellular response to heat cellular response to unfolded protein protein refolding ATPase activity, coupled negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein binding involved in protein folding cell body unfolded protein binding chaperone mediated protein folding requiring cofactor misfolded protein binding positive regulation of microtubule nucleation regulation of mitotic spindle assembly COP9 signalosome uc008ceo.1 uc008ceo.2 uc008ceo.3 
ENSMUST00000172767.9 Marchf2 ENSMUST00000172767.9 membrane associated ring-CH-type finger 2, transcript variant 2 (from RefSeq NM_001252480.1) ENSMUST00000172767.1 ENSMUST00000172767.2 ENSMUST00000172767.3 ENSMUST00000172767.4 ENSMUST00000172767.5 ENSMUST00000172767.6 ENSMUST00000172767.7 ENSMUST00000172767.8 MARH2_MOUSE March2 NM_001252480 Q8C4Q5 Q99M02 Rnf172 uc008bzk.1 uc008bzk.2 uc008bzk.3 uc008bzk.4 E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (By similarity). Ubiquitinates and therefore mediates the degradation of DLG1 (By similarity). Regulates the intracellular trafficking and secretion of alpha1- antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (By similarity). Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation (PubMed:32935379). May be involved in endosomal trafficking through interaction with STX6. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with STX6; the interaction promotes MARCHF2-mediated ubiquitination and degradation of CFTR (By similarity). Interacts with MARCHF3 (By similarity). Interacts with GOPC/CAL; the interaction leads to CFTR ubiquitination and degradation (By similarity). Interacts with CFTR; the interaction leads to CFTR ubiqtuitination and degradation (By similarity). Interacts (via PDZ domain) with DLG1 (via PDZ domains); the interaction leads to DLG1 ubiqtuitination and degradation (By similarity). Interacts with ERGIC3 (By similarity). Interacts with ADRB2 (By similarity). Interacts with IKBKG/NEMO; during the late stages of macrophage viral and bacterial infection; the interaction leads to ubiquitination and degradation of IKBKG/NEMO (PubMed:32935379). Endoplasmic reticulum membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Endosome membrane ; Multi- pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasm Cell membrane ; Multi-pass membrane protein Induced in macrophages by viral or bacterial infection. The RING-CH-type zinc finger domain is required for E3 ligase activity. Knockout mice are phenotypically normal (PubMed:32935379). Increase in cytokine production following viral and bacterial challenge, including increases in Ifnb1, Il6, Il12, Ccl5, Cxcl10 and Tnf protein abundance (PubMed:32935379). Increase in survival following exposure to a lethal dose of L.monocytogenes and decrease in bacterial load in the spleen and liver (PubMed:32935379). Increase in susceptibility to endotoxin shock (PubMed:32935379). Sequence=BAC38235.1; Type=Frameshift; Evidence=; ubiquitin-protein transferase activity lysosome lysosomal membrane endosome endoplasmic reticulum endoplasmic reticulum membrane endocytosis zinc ion binding endosome membrane membrane integral component of membrane protein ubiquitination transferase activity cytoplasmic vesicle metal ion binding uc008bzk.1 uc008bzk.2 uc008bzk.3 uc008bzk.4 
ENSMUST00000172775.4 Msx3 ENSMUST00000172775.4 msh homeobox 3, transcript variant 1 (from RefSeq NM_010836.3) ENSMUST00000172775.1 ENSMUST00000172775.2 ENSMUST00000172775.3 MSX3_MOUSE Msx-3 NM_010836 P70246 P70354 Q03360 Q80W10 uc012fwf.1 uc012fwf.2 uc012fwf.3 Acts as a potent transcriptional repressor of MSX1. Part of a complex composed of MSX3, CREBBP/CBP AND EP300/p300; the interaction with MSX3 decreases histone acetylation activity (PubMed:11115394). Interacts with HDAC1 (PubMed:11115394). Interacts with CREBBP/CBP, TBP and SP1 (PubMed:10215616). Nucleus Restricted to the dorsal embryonic central nervous system. Belongs to the Msh homeobox family. Sequence=AAH51983.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development negative regulation of histone acetylation sequence-specific DNA binding embryonic morphogenesis uc012fwf.1 uc012fwf.2 uc012fwf.3 
ENSMUST00000172785.8 H2-D1 ENSMUST00000172785.8 histocompatibility 2, D region locus 1 (from RefSeq NM_010380.3) D(b) gene ENSMUST00000172785.1 ENSMUST00000172785.2 ENSMUST00000172785.3 ENSMUST00000172785.4 ENSMUST00000172785.5 ENSMUST00000172785.6 ENSMUST00000172785.7 H2-D1 H2D NM_010380 Q792Z7 Q792Z7_MOUSE uc008chg.1 uc008chg.2 uc008chg.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. immune system process antigen processing and presentation of peptide antigen via MHC class I immune response membrane integral component of membrane antigen processing and presentation MHC class I protein complex uc008chg.1 uc008chg.2 uc008chg.3 
ENSMUST00000172814.8 Esp36 ENSMUST00000172814.8 Esp36 (from geneSymbol) AB307016 ENSMUST00000172814.1 ENSMUST00000172814.2 ENSMUST00000172814.3 ENSMUST00000172814.4 ENSMUST00000172814.5 ENSMUST00000172814.6 ENSMUST00000172814.7 Esp36 G3UZD8 G3UZD8_MOUSE uc289lch.1 uc289lch.2 pheromone activity extracellular space biological_process uc289lch.1 uc289lch.2 
ENSMUST00000172815.4 Gm19345 ENSMUST00000172815.4 predicted gene, 19345 (from RefSeq NM_001270489.1) ENSMUST00000172815.1 ENSMUST00000172815.2 ENSMUST00000172815.3 G3UYD9 G3UYD9_MOUSE Gm19345 NM_001270489 uc009fnl.1 uc009fnl.2 uc009fnl.3 uc009fnl.4 uc009fnl.1 uc009fnl.2 uc009fnl.3 uc009fnl.4 
ENSMUST00000172817.2 Smim40 ENSMUST00000172817.2 small integral membrane protein 40, transcript variant 2 (from RefSeq NM_001369206.1) A0A2I3BQC3 A0A2I3BQC3_MOUSE ENSMUST00000172817.1 NM_001369206 Platr17 Smim40 uc008bzy.1 uc008bzy.2 membrane integral component of membrane uc008bzy.1 uc008bzy.2 
ENSMUST00000172818.8 Pja2 ENSMUST00000172818.8 praja ring finger ubiquitin ligase 2, transcript variant 1 (from RefSeq NM_001025309.1) ENSMUST00000172818.1 ENSMUST00000172818.2 ENSMUST00000172818.3 ENSMUST00000172818.4 ENSMUST00000172818.5 ENSMUST00000172818.6 ENSMUST00000172818.7 Kiaa0438 NM_001025309 PJA2_MOUSE Q3TH95 Q80U04 Q810E3 Q91W46 Q99KC0 Rnf131 uc008dfu.1 uc008dfu.2 uc008dfu.3 Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype. Plays a role in ciliogenesis by ubiquitinating OFD1. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Binds ubiquitin-conjugating enzymes (E2s). In vitro, interacts with the ubiquitin-conjugating enzyme, UBE2D2. The phosphorylated form interacts with PRKAR1A, PRKAR2A and PRKAR2B. Binds the catalytic subunits of cAMP-dependent protein kinase. Interacts with MFHAS1. Interacts with TBC1D31; the interaction is direct and recruits PJA2 to centrosomes. Q80U04; P61809: Cdk5r1; NbExp=2; IntAct=EBI-1801691, EBI-7840438; Cytoplasm Cell membrane Endoplasmic reticulum membrane ; Peripheral membrane protein Golgi apparatus membrane ; Peripheral membrane protein Synapse Postsynaptic density Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus (By similarity). Expressed in the postsynaptic density region of synapses (By similarity). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80U04-1; Sequence=Displayed; Name=2; IsoId=Q80U04-2; Sequence=VSP_023199; Sequence=BAC65564.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Golgi membrane ubiquitin-protein transferase activity protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane inflammatory response long-term memory regulation of protein kinase A signaling postsynaptic density membrane protein ubiquitination transferase activity cell junction positive regulation of toll-like receptor 2 signaling pathway protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding hippo signaling regulation of macrophage activation innate immune response intermediate filament cytoskeleton synapse postsynaptic membrane positive regulation of JNK cascade metal ion binding ubiquitin protein ligase activity positive regulation of p38MAPK cascade uc008dfu.1 uc008dfu.2 uc008dfu.3 
ENSMUST00000172821.4 Vax1 ENSMUST00000172821.4 ventral anterior homeobox 1 (from RefSeq NM_009501.3) ENSMUST00000172821.1 ENSMUST00000172821.2 ENSMUST00000172821.3 NM_009501 O88880 Q2NKI2 VAX1_MOUSE uc008ibg.1 uc008ibg.2 uc008ibg.3 uc008ibg.4 This gene encodes a member of the EMX homeobox protein family. The encoded protein functions as a transcription factor which is important in the development of anterior ventral forebrain and visual system. Disruption of this gene causes impairment in the developing forebrain, where the encoded protein is necessary for axon guidance and major tract formation. [provided by RefSeq, Dec 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7974084.27712.1, AF064554.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2NKI2-1; Sequence=Displayed; Name=2; IsoId=Q2NKI2-2; Sequence=VSP_019397; At 9.5 dpc, expressed in the forebrain, through the optic stalk and ending in the proximal portion of the optic vesicle. At 10.5 dpc, expressed in the optic stalk, outer layer of the optic cup, and the primordium of the pigment epithelium. In the pigment epithelium, down-regulated after 11.5 dpc, and expression restricted to the optic stalk and the ventral forebrain. Belongs to the EMX homeobox family. Sequence=AAI11819.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding neuron migration DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development nervous system development negative regulation of neuroblast proliferation axon guidance central nervous system development brain development cell differentiation neuron differentiation chromatin DNA binding skeletal muscle cell differentiation camera-type eye development sequence-specific DNA binding palate development uc008ibg.1 uc008ibg.2 uc008ibg.3 uc008ibg.4 
ENSMUST00000172831.8 Rgs22 ENSMUST00000172831.8 regulator of G-protein signalling 22 (from RefSeq NM_001195748.1) ENSMUST00000172831.1 ENSMUST00000172831.2 ENSMUST00000172831.3 ENSMUST00000172831.4 ENSMUST00000172831.5 ENSMUST00000172831.6 ENSMUST00000172831.7 G3UYX5 NM_001195748 RGS22_MOUSE uc011zsd.1 uc011zsd.2 uc011zsd.3 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Interacts with GNA11, GNA12 and GNA13. Cytoplasm Nucleus Note=Expressed in the cytoplasm of spermatogonia and spermatocytes. In spermatids, also expressed in the nucleus. Expressed testis, including in Leydig cells and spermatogenic cells from the spermatogonia to spermatid stages (at protein level). G-protein alpha-subunit binding nucleus cytoplasm negative regulation of signal transduction uc011zsd.1 uc011zsd.2 uc011zsd.3 
ENSMUST00000172838.3 Gm4425 ENSMUST00000172838.3 predicted gene 4425 (from RefSeq NR_136920.1) ENSMUST00000172838.1 ENSMUST00000172838.2 NR_136920 uc011ykv.1 uc011ykv.2 uc011ykv.1 uc011ykv.2 
ENSMUST00000172856.8 Znrf1 ENSMUST00000172856.8 E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation (PubMed:28593998, PubMed:37158982). Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL (PubMed:20107048). Promotes neurodegeneration by mediating 'Lys-48'- linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (PubMed:22057101). Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery. Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production. Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response. (from UniProt Q91V17) AK078819 ENSMUST00000172856.1 ENSMUST00000172856.2 ENSMUST00000172856.3 ENSMUST00000172856.4 ENSMUST00000172856.5 ENSMUST00000172856.6 ENSMUST00000172856.7 Nin283 Q8C5D7 Q91V17 ZNRF1_MOUSE uc292dgt.1 uc292dgt.2 E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation (PubMed:28593998, PubMed:37158982). Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL (PubMed:20107048). Promotes neurodegeneration by mediating 'Lys-48'- linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (PubMed:22057101). Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery. Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production. Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with AKT1, GLUL and TUBB2A (PubMed:19737534, PubMed:20107048, PubMed:22057101). Interacts with ZNRF2. Interacts (via its RING domain) with UBE2N. Interacts (when phosphorylated) with YWHAE (By similarity). Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein Note=Associated with synaptic vesicle membranes in neurons. The RING-type zinc finger domain is required for E3 ligase activity. N-myristoylation targets ZNRF1 to intracellular membranes. Phosophorylated by SRC at Tyr-103; leading to 'Lys-63'-linked ubiquitination of TLR3, lysosomal trafficking and degradation. ZNRF1-deficient mice are more resistant to infection by encephalomyocarditis virus (ECMV) and SARS-CoV-2 with enhanced type I interferon production (PubMed:37158982). However, the display exacerbated lung barrier damage triggered by antiviral immunity, leading to enhanced susceptibility to respiratory bacterial superinfections. Mice are also are more resistant to LPS and CLP- induced sepsis (PubMed:28593998). ubiquitin-protein transferase activity protein binding lysosome endosome cytosol cytoskeleton organization membrane protein ubiquitination transferase activity cell junction synaptic vesicle membrane cytoplasmic vesicle proteasome-mediated ubiquitin-dependent protein catabolic process synapse metal ion binding ubiquitin protein ligase activity protein K48-linked ubiquitination uc292dgt.1 uc292dgt.2 
ENSMUST00000172863.2 Vmn1r247 ENSMUST00000172863.2 vomeronasal 1 receptor 247 (from RefSeq NM_001167165.1) D3YTW8 D3YTW8_MOUSE D3YTX7 D3YTX8 E9Q2L6 E9Q8L4 E9Q8L5 ENSMUST00000172863.1 G3UYH3 Gm4175 Gm4214 NM_001167165 Vmn1r247 Vmn1r258 uc012fdi.1 uc012fdi.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fdi.1 uc012fdi.2 
ENSMUST00000172874.3 4833427F10Rik ENSMUST00000172874.3 RIKEN cDNA 4833427F10 gene (from RefSeq NR_045459.1) ENSMUST00000172874.1 ENSMUST00000172874.2 NR_045459 uc029thk.1 uc029thk.2 uc029thk.3 uc029thk.1 uc029thk.2 uc029thk.3 
ENSMUST00000172891.2 Gm20407 ENSMUST00000172891.2 Gm20407 (from geneSymbol) ENSMUST00000172891.1 uc289rob.1 uc289rob.2 uc289rob.1 uc289rob.2 
ENSMUST00000172898.2 Mgat4e ENSMUST00000172898.2 MGAT4 family, member E, transcript variant 2 (from RefSeq NM_001291015.1) A6H684 B7ZNB9 E9Q5L0 ENSMUST00000172898.1 MGT4E_MOUSE Mgat4e NM_001291015 Q8C1J0 uc011wsf.1 uc011wsf.2 uc011wsf.3 Glycosyltransferase-like protein that may participate in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Protein modification; protein glycosylation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A6H684-1; Sequence=Displayed; Name=2; IsoId=A6H684-2; Sequence=VSP_054935; Sequence=AAI45150.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC25485.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC25485.1; Type=Frameshift; Evidence=; protein glycosylation protein N-linked glycosylation acetylglucosaminyltransferase activity transferase activity transferase activity, transferring glycosyl groups uc011wsf.1 uc011wsf.2 uc011wsf.3 
ENSMUST00000172912.8 H2-K1 ENSMUST00000172912.8 histocompatibility 2, K1, K region, transcript variant 2 (from RefSeq NM_001347346.2) ENSMUST00000172912.1 ENSMUST00000172912.2 ENSMUST00000172912.3 ENSMUST00000172912.4 ENSMUST00000172912.5 ENSMUST00000172912.6 ENSMUST00000172912.7 H2-K1 NM_001347346 Q3TH01 Q3TH01_MOUSE uc008caq.1 uc008caq.2 uc008caq.3 uc008caq.4 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. immune system process antigen processing and presentation of peptide antigen via MHC class I immune response membrane integral component of membrane antigen processing and presentation MHC class I protein complex uc008caq.1 uc008caq.2 uc008caq.3 uc008caq.4 
ENSMUST00000172939.8 Ttc6 ENSMUST00000172939.8 tetratricopeptide repeat domain 6 (from RefSeq NM_001312644.1) ENSMUST00000172939.1 ENSMUST00000172939.2 ENSMUST00000172939.3 ENSMUST00000172939.4 ENSMUST00000172939.5 ENSMUST00000172939.6 ENSMUST00000172939.7 G3UYY4 G3UYY4_MOUSE NM_001312644 Ttc6 uc288gno.1 uc288gno.2 molecular_function cellular_component biological_process uc288gno.1 uc288gno.2 
ENSMUST00000172951.2 Grm7 ENSMUST00000172951.2 glutamate receptor, metabotropic 7, transcript variant 1 (from RefSeq NM_177328.3) ENSMUST00000172951.1 GRM7_MOUSE Gprc1g Mglur7 NM_177328 Q68ED2 uc009ddt.1 uc009ddt.2 uc009ddt.3 G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (By similarity). Homodimer (By similarity). Interacts with PICK1. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 3 family. adenylate cyclase inhibiting G-protein coupled glutamate receptor activity group III metabotropic glutamate receptor activity conditioned taste aversion behavioral fear response G-protein coupled receptor activity voltage-gated calcium channel activity calcium channel regulator activity calcium ion binding calmodulin binding rough endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane cell cortex signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway chemical synaptic transmission sensory perception of sound memory short-term memory glutamate receptor activity associative learning cell surface adenylate cyclase inhibitor activity negative regulation of glutamate secretion membrane integral component of membrane glutamate binding transmission of nerve impulse PDZ domain binding axon dendrite adult behavior regulation of cyclase activity asymmetric synapse macromolecular complex multicellular organismal response to stress presynaptic membrane protein homodimerization activity neuronal cell body terminal bouton dendritic shaft receptor complex negative regulation of neuron apoptotic process axon terminus synapse postsynaptic membrane calcium-dependent protein binding presynaptic active zone presynaptic active zone membrane neurological system process response to stimulus regulation of synaptic transmission, glutamatergic calcium ion transmembrane transport serine binding glutamatergic synapse GABA-ergic synapse integral component of presynaptic membrane integral component of presynaptic active zone membrane regulation of neuron death regulation of synaptic vesicle exocytosis uc009ddt.1 uc009ddt.2 uc009ddt.3 
ENSMUST00000172958.8 Pagr1b ENSMUST00000172958.8 Pagr1b (from geneSymbol) AK082775 ENSMUST00000172958.1 ENSMUST00000172958.2 ENSMUST00000172958.3 ENSMUST00000172958.4 ENSMUST00000172958.5 ENSMUST00000172958.6 ENSMUST00000172958.7 uc291vrf.1 uc291vrf.2 uc291vrf.3 uc291vrf.1 uc291vrf.2 uc291vrf.3 
ENSMUST00000172965.3 Or14c45 ENSMUST00000172965.3 Odorant receptor. (from UniProt Q7TS07) ENSMUST00000172965.1 ENSMUST00000172965.2 Olfr295 Olfr297 Or14c45 Q7TS07 Q7TS07_MOUSE uc291sjj.1 uc291sjj.2 Odorant receptor. Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291sjj.1 uc291sjj.2 
ENSMUST00000172972.3 Gm20540 ENSMUST00000172972.3 Gm20540 (from geneSymbol) ENSMUST00000172972.1 ENSMUST00000172972.2 uc289lud.1 uc289lud.2 uc289lud.3 uc289lud.1 uc289lud.2 uc289lud.3 
ENSMUST00000172979.4 H2-Q5 ENSMUST00000172979.4 H2-Q5 (from geneSymbol) AK013097 ENSMUST00000172979.1 ENSMUST00000172979.2 ENSMUST00000172979.3 uc289knh.1 uc289knh.2 uc289knh.1 uc289knh.2 
ENSMUST00000172989.2 Vmn1r243 ENSMUST00000172989.2 vomeronasal 1 receptor 243 (from RefSeq NM_001167158.1) ENSMUST00000172989.1 Gm4133 Gm4187 K9J7G6 K9J7G6_MOUSE NM_001167158 Vmn1r243 Vmn1r253 uc012fbu.1 uc012fbu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fbu.1 uc012fbu.2 
ENSMUST00000172997.3 Uncx ENSMUST00000172997.3 UNC homeobox (from RefSeq NM_013702.4) ENSMUST00000172997.1 ENSMUST00000172997.2 NM_013702 O08934 P70457 Q78DU3 UNC4_MOUSE Uncx4.1 uc009agv.1 uc009agv.2 uc009agv.3 uc009agv.4 Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions. Nucleus Expressed in the paraxial mesoderm, in the developing kidney and central nervous system. In the somite, it is restricted to the caudal half of the newly formed somite and sclerotome. In the central nervous system, it is detected in the developing spinal cord, hindbrain, mesencephalon and telencephalon. Expressed in adult and embryonic magnocellular neurons of the hypothalamo-neurohypophysial system. Mice die perinatally and exhibit severe malformations of the axial skeleton. Pedicles of the neural arches and proximal ribs are not formed. In addition, dorsal root ganglia are disorganized. In the hypothalamo-neurohypophysial system, neurons are viable and able to express neuropeptides; however, the connectivity of magnocellular neurons with posterior pituitary elements is compromised. Marker of antero-posterior subdivisions of the somite. Belongs to the paired homeobox family. Unc-4 subfamily. cartilage condensation DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development pattern specification process nervous system development regulation of gene expression dorsal spinal cord development olfactory bulb interneuron differentiation cell differentiation common myeloid progenitor cell proliferation sequence-specific DNA binding regulation of cell differentiation uc009agv.1 uc009agv.2 uc009agv.3 uc009agv.4 
ENSMUST00000173002.8 C1qtnf2 ENSMUST00000173002.8 C1qtnf2 (from geneSymbol) AK007683 C1qtnf2 ENSMUST00000173002.1 ENSMUST00000173002.2 ENSMUST00000173002.3 ENSMUST00000173002.4 ENSMUST00000173002.5 ENSMUST00000173002.6 ENSMUST00000173002.7 G3V001 G3V001_MOUSE uc287xnj.1 uc287xnj.2 extracellular region collagen trimer uc287xnj.1 uc287xnj.2 
ENSMUST00000173014.3 Dio3 ENSMUST00000173014.3 deiodinase, iodothyronine type III (from RefSeq NM_172119.2) ENSMUST00000173014.1 ENSMUST00000173014.2 G3UY28 IOD3_MOUSE NM_172119 Q3UKD2 Q91ZI8 uc007pbi.1 uc007pbi.2 uc007pbi.3 This is an intronless, imprinted gene that is preferentially expressed from the paternal allele in the mouse fetus. The encoded protein belongs to the iodothyronine deiodinase family, and catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5' triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. It is highly expressed in placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It thus plays a critical role in mammalian development by regulating circulating fetal thyroid hormone concentration. Knockout mice lacking this gene exhibit severe abnormalities related to development and reproduction. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK140797.1, AK146060.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 12176332, 12399446 protein contains selenocysteine :: PMID: 9886816 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. Reaction=3,3',5'-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L- thyroxine; Xref=Rhea:RHEA:18897, ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:16382, ChEBI:CHEBI:17499, ChEBI:CHEBI:57261, ChEBI:CHEBI:58448; EC=1.21.99.3; Evidence=; Homodimer. May undergo minor heretodimerization with DIO1 and DIO2 (By similarity). Cell membrane ; Single-pass type II membrane protein Endosome membrane ; Single-pass type II membrane protein Belongs to the iodothyronine deiodinase family. It is uncertain whether Met-1 or Met-27 is the initiator. Sequence=AAI06848.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI06849.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAL23960.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE24483.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE26869.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; thyroxine 5'-deiodinase activity endosome plasma membrane apoptotic process endosome membrane membrane integral component of membrane oxidoreductase activity thyroxine 5-deiodinase activity positive regulation of multicellular organism growth thyroid hormone metabolic process thyroid hormone catabolic process hormone biosynthetic process negative regulation of eye photoreceptor cell development retinal cone cell development oxidation-reduction process retinal cone cell apoptotic process uc007pbi.1 uc007pbi.2 uc007pbi.3 
ENSMUST00000173019.8 Rps28 ENSMUST00000173019.8 Belongs to the eukaryotic ribosomal protein eS28 family. (from UniProt Q059I1) BC125644 ENSMUST00000173019.1 ENSMUST00000173019.2 ENSMUST00000173019.3 ENSMUST00000173019.4 ENSMUST00000173019.5 ENSMUST00000173019.6 ENSMUST00000173019.7 Q059I1 Q059I1_MOUSE Rps28 uc289jwm.1 uc289jwm.2 Belongs to the eukaryotic ribosomal protein eS28 family. cytoplasmic translation structural constituent of ribosome ribosome rRNA processing translation cytosolic small ribosomal subunit ribosome biogenesis ribosomal small subunit biogenesis polysomal ribosome uc289jwm.1 uc289jwm.2 
ENSMUST00000173025.8 2410017I17Rik ENSMUST00000173025.8 RIKEN cDNA 2410017I17 gene (from RefSeq NR_033517.1) ENSMUST00000173025.1 ENSMUST00000173025.2 ENSMUST00000173025.3 ENSMUST00000173025.4 ENSMUST00000173025.5 ENSMUST00000173025.6 ENSMUST00000173025.7 NR_033517 uc012asm.1 uc012asm.2 uc012asm.3 uc012asm.1 uc012asm.2 uc012asm.3 
ENSMUST00000173033.8 Mocs1 ENSMUST00000173033.8 molybdenum cofactor synthesis 1, transcript variant 1 (from RefSeq NM_020042.3) B2RVW8 B7ZWI5 ENSMUST00000173033.1 ENSMUST00000173033.2 ENSMUST00000173033.3 ENSMUST00000173033.4 ENSMUST00000173033.5 ENSMUST00000173033.6 ENSMUST00000173033.7 MOCS1_MOUSE NM_020042 Q5RKZ7 Q8R058 Q9JL32 Q9JL33 uc008cyg.1 uc008cyg.2 uc008cyg.3 uc008cyg.4 Isoform Mocs1a and isoform Mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). Mocs1a catalyzes the cyclization of GTP to (8S)- 3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and Mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'- triphosphate to cPMP. Reaction=AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L- methionine; Xref=Rhea:RHEA:49576, ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319, ChEBI:CHEBI:17499, ChEBI:CHEBI:37565, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:131766; EC=4.1.99.22; Evidence=; Reaction=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate; Xref=Rhea:RHEA:49580, ChEBI:CHEBI:33019, ChEBI:CHEBI:59648, ChEBI:CHEBI:131766; EC=4.6.1.17; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate. ; Cofactor biosynthesis; molybdopterin biosynthesis. Isoform Mocs1a and isoform Mocs1b probably form a heterooligomer. Event=Alternative splicing; Named isoforms=3; Name=Mocs1b; IsoId=Q5RKZ7-1; Sequence=Displayed; Name=Mocs1a; IsoId=Q5RKZ7-2; Sequence=VSP_036850, VSP_036851; Name=3; IsoId=Q5RKZ7-3; Sequence=VSP_036849; Death between days 1 and 11 after birth, due to a progressive neurological disorder caused by massive cell death. Death is caused by the absence of molybdenum cofactor, resulting in elevated sulfite and diminished sulfate levels throughout the organism. Mice do not possess any sulfite oxidase or xanthine dehydrogenase activity. No organ abnormalities are observed and the synaptic localization of inhibitory receptors appears normal. Long-term rescue results have been obtained in mice lacking Mocs1 thanks to an adeno-associated virus- mediated gene transfer. In the C-terminal section; belongs to the MoaC family. In the N-terminal section; belongs to the radical SAM superfamily. MoaA family. The C-terminus of Mocs1a was previously believed to be thiocarboxylated, but it is now known not to be the case. Sequence=AAI47413.1; Type=Erroneous initiation; Evidence=; nucleotide binding catalytic activity GTP binding Mo-molybdopterin cofactor biosynthetic process lyase activity molybdopterin synthase complex molybdopterin cofactor biosynthetic process metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding GTP 3',8'-cyclase activity cyclic pyranopterin monophosphate synthase activity uc008cyg.1 uc008cyg.2 uc008cyg.3 uc008cyg.4 
ENSMUST00000173055.3 Esp34 ENSMUST00000173055.3 Esp34 (from geneSymbol) AB307013 ENSMUST00000173055.1 ENSMUST00000173055.2 Esp34 G3UXG0 G3UXG0_MOUSE uc289lcl.1 uc289lcl.2 pheromone activity extracellular space biological_process membrane integral component of membrane uc289lcl.1 uc289lcl.2 
ENSMUST00000173101.3 Vmn1r172 ENSMUST00000173101.3 vomeronasal 1 receptor 172, transcript variant 2 (from RefSeq NM_001362150.1) ENSMUST00000173101.1 ENSMUST00000173101.2 NM_001362150 Q9EPS4 Q9EPS4_MOUSE V1rd9 Vmn1r172 uc012ffa.1 uc012ffa.2 uc012ffa.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012ffa.1 uc012ffa.2 uc012ffa.3 
ENSMUST00000173107.8 Slit2 ENSMUST00000173107.8 slit guidance ligand 2, transcript variant 4 (from RefSeq NR_111900.2) E9QKB4 ENSMUST00000173107.1 ENSMUST00000173107.2 ENSMUST00000173107.3 ENSMUST00000173107.4 ENSMUST00000173107.5 ENSMUST00000173107.6 ENSMUST00000173107.7 NR_111900 Q9R1B9 Q9Z166 SLIT2_MOUSE uc008xjo.1 uc008xjo.2 uc008xjo.3 uc008xjo.4 uc008xjo.5 uc008xjo.6 uc008xjo.7 The protein encoded by this gene is a member of the Slit family of secreted glycoproteins, which function as ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. In mammals, members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Mice deficient for this gene exhibit abnormal axonal projections in the embryonic forebrain and develop supernumerary uretic buds that maintain improper connections to the nephric duct. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal cord development, may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal cord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system, appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration (By similarity). Homodimer. Interacts with GREM1 (By similarity). Binds ROBO1 and ROBO2 with high affinity. Secreted Note=The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated. Expressed in developing eye, in the optic stalk, and in the ventral diencephalon. According to PubMed:10864955 is expressed during retinal development by 14.5 dpc throughout the RGC layer, and is clearly restricted to the inner nuclear layer at 17.5 dpc. In the developing optic chiasm is strongly expressed at 12.5 dpc at the ventral midline of the diencephalon in the region in which the RGC axons enter the brain and turn to grow ventrally, the region expression includes the position of the glial knot. At 14.5 dpc expression is maintained at the ventral midline of the diencephalon, in a region directly dorsal to the site of axon divergence. Outside the developing brain. According to PubMed:10433822 prominently expressed in neural and mesodermally derived tissues. From 8.5 dpc to 9.5 dpc expressed strongly in the roof plate, floor plate, and notochord. Beginning at 10.5 dpc intense expression is also observed in the motor columns. By 13.5 dpc the expression decreased in the roof plate but is still retained in the floor plate and motor columns. In the rostral CNS between 8.5 dpc and 9.5 dpc expressed intensely in the dorsal neuroepithelium overlying the hindbrain, in the dorsal midline of the midbrain and forebrain, and in the ventral midbrain region. By 10.5 dpc to 11.5 dpc, additional intense expression is observed in the rhombic lip and the rostral midline. From 13.5 dpc to 17.5 dpc, the expression decreased dorsally and continued to be detected in the ventral mesencephalon and diencephalon. Outside neuronal development expressed between 8.5 dpc and 9.5 dpc in the clefts between the first, the second, and the third branchial arches. From 10.5 dpc to 11.5 dpc, expression is detected in the nasal pit, the developing eye, the otic vesicle, and the visceral grooves. From 13.5 dpc to 17.5 dpc expressed in the developing cochlea (in a pattern consistent with expression in the organ of Corti), in the olfactory epithelium and in the inner neuronal layer of the retina and in the optic nerve. At this stage also expressed in the tongue, in the tooth primordium, and in the outer root sheath of the whisker follicle in the layer surrounding the bulb. At 11.5 dpc is intensely expressed in the rostral lateral ridge flanking the forelimb buds and in lateral ridge tissue between the fore- and the hindlimb buds. Weak expression is observed in a segmented pattern in the posterior part of the sclerotome. Expression is notably absent in the base of the limb buds and weak expression is observed in the interdigital regions of the distal limb bud beginning at 11.5 dpc. By 13.5 dpc intensely expressed in interdigital mesenchyme. The leucine-rich repeat domain is sufficient for guiding both axon projection and neuronal migration, in vitro. Mice show significant axon guidance errors in a variety of pathways, including corticofugal, callosal and thalamocortical tracts. Mice double-deficient in SLIT1 and SLIT2 show retinal axon guidance defects and a disorganized lateral olfactory tract (LOT). metanephros development ureteric bud development in utero embryonic development negative regulation of protein phosphorylation cell migration involved in sprouting angiogenesis negative regulation of leukocyte chemotaxis aortic valve morphogenesis pulmonary valve morphogenesis GTPase inhibitor activity receptor binding extracellular matrix structural constituent calcium ion binding protein binding extracellular region extracellular space cytoplasm plasma membrane chemotaxis multicellular organism development nervous system development axonogenesis axon guidance motor neuron axon guidance heparin binding negative regulation of cell proliferation cell surface negative regulation of lamellipodium assembly negative regulation of endothelial cell migration negative regulation of gene expression negative regulation of smooth muscle cell migration olfactory bulb development chemorepulsion involved in postnatal olfactory bulb interneuron migration corticospinal neuron axon guidance through spinal cord telencephalon cell migration cell differentiation negative regulation of cell growth negative regulation of cell migration negative regulation of axon extension negative regulation of actin filament polymerization retinal ganglion cell axon guidance dorsal/ventral axon guidance negative regulation of GTPase activity Roundabout signaling pathway identical protein binding protein homodimerization activity positive regulation of apoptotic process negative regulation of vascular permeability laminin-1 binding proteoglycan binding heparan sulfate proteoglycan binding chemorepellent activity Roundabout binding branching morphogenesis of an epithelial tube neuron projection morphogenesis axon extension involved in axon guidance negative regulation of inflammatory response negative chemotaxis induction of negative chemotaxis negative regulation of small GTPase mediated signal transduction ventricular septum morphogenesis mammary gland duct morphogenesis mammary duct terminal end bud growth negative regulation of chemokine-mediated signaling pathway cellular response to heparin negative regulation of smooth muscle cell chemotaxis negative regulation of mononuclear cell migration negative regulation of neutrophil chemotaxis negative regulation of monocyte chemotaxis negative regulation of retinal ganglion cell axon guidance negative regulation of cellular response to growth factor stimulus cell-cell adhesion uc008xjo.1 uc008xjo.2 uc008xjo.3 uc008xjo.4 uc008xjo.5 uc008xjo.6 uc008xjo.7 
ENSMUST00000173114.8 Csnk2b ENSMUST00000173114.8 casein kinase 2, beta polypeptide, transcript variant 3 (from RefSeq NM_001303445.1) CSK2B_MOUSE Ck2n ENSMUST00000173114.1 ENSMUST00000173114.2 ENSMUST00000173114.3 ENSMUST00000173114.4 ENSMUST00000173114.5 ENSMUST00000173114.6 ENSMUST00000173114.7 NM_001303445 P07312 P13862 P67871 Q3TTJ7 uc008cfu.1 uc008cfu.2 uc008cfu.3 uc008cfu.4 This gene encodes the beta subunit of the casein kinase 2 enzyme, which is a heterotetramer comprised of alpha and/or alpha-prime catalytic subunits and two regulatory beta subunits. Casein kinase 2 is involved in the regulation of several cellular processes including gene expression, protein synthesis and cell proliferation. Knockout of this gene in mice leads to embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]. Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:16818610). Participates in Wnt signaling (PubMed:10806215). Casein kinase II/CK2 is a tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with DYNLT2 (By similarity). Interacts with CD163. Also a component of a CK2-SPT16- SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1 (By similarity). Interacts (via KSSR motif) with ARK2N. Interacts with JUN and ARK2N; mediates the interaction between ARK2N and JUN (By similarity). P67871; Q9WTL8: Bmal1; NbExp=8; IntAct=EBI-348179, EBI-644534; P67871; P97784: Cry1; NbExp=4; IntAct=EBI-348179, EBI-1266607; P67871; Q9R194: Cry2; NbExp=3; IntAct=EBI-348179, EBI-1266619; P67871; Q60737: Csnk2a1; NbExp=5; IntAct=EBI-348179, EBI-771698; P67871; P11985-2: Dynlt2; NbExp=2; IntAct=EBI-348179, EBI-1781298; Nucleus The KSSR motif is part of a protein interaction pocket that mediates interaction with cellular and viral proteins. Phosphorylated by alpha subunit. Belongs to the casein kinase 2 subunit beta family. chromatin chromatin binding protein serine/threonine kinase activity receptor binding protein binding nucleus cytoplasm plasma membrane cilium protein kinase CK2 complex transcription factor binding positive regulation of pathway-restricted SMAD protein phosphorylation Wnt signaling pathway nuclear matrix peptidyl-threonine phosphorylation protein kinase regulator activity protein domain specific binding positive regulation of activin receptor signaling pathway adiponectin-activated signaling pathway identical protein binding cell projection ribonucleoprotein complex binding negative regulation of blood vessel endothelial cell migration regulation of protein kinase activity metal ion binding endothelial tube morphogenesis postsynapse glutamatergic synapse PcG protein complex uc008cfu.1 uc008cfu.2 uc008cfu.3 uc008cfu.4 
ENSMUST00000173128.2 Gm19684 ENSMUST00000173128.2 Gm19684 (from geneSymbol) AK156795 ENSMUST00000173128.1 G3UZ45 G3UZ45_MOUSE Gm19684 uc012ask.1 uc012ask.2 uc012ask.3 uc012ask.1 uc012ask.2 uc012ask.3 
ENSMUST00000173131.8 Gm20537 ENSMUST00000173131.8 Gm20537 (from geneSymbol) AK046839 ENSMUST00000173131.1 ENSMUST00000173131.2 ENSMUST00000173131.3 ENSMUST00000173131.4 ENSMUST00000173131.5 ENSMUST00000173131.6 ENSMUST00000173131.7 G3UYK7 G3UYK7_MOUSE Gm20537 uc292jkv.1 uc292jkv.2 uc292jkv.1 uc292jkv.2 
ENSMUST00000173135.8 Dap3 ENSMUST00000173135.8 death associated protein 3, transcript variant 3 (from RefSeq NM_001368419.1) ENSMUST00000173135.1 ENSMUST00000173135.2 ENSMUST00000173135.3 ENSMUST00000173135.4 ENSMUST00000173135.5 ENSMUST00000173135.6 ENSMUST00000173135.7 Mrps29 NM_001368419 Q8C2B2 Q8CCQ8 Q8VCK8 Q9CRT4 Q9CS11 Q9D5V9 Q9ER88 RT29_MOUSE uc290gru.1 uc290gru.2 Involved in mediating interferon-gamma-induced cell death. Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with DELE1. Interacts with NOA1. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ER88-1; Sequence=Displayed; Name=2; IsoId=Q9ER88-2; Sequence=VSP_008916; Belongs to the mitochondrion-specific ribosomal protein mS29 family. Sequence=BAB29240.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB29605.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC27790.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC40673.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; structural constituent of ribosome nucleoplasm mitochondrion mitochondrial matrix mitochondrial ribosome mitochondrial small ribosomal subunit ribosome apoptotic process apoptotic mitochondrial changes small ribosomal subunit uc290gru.1 uc290gru.2 
ENSMUST00000173141.2 Gm20546 ENSMUST00000173141.2 Gm20546 (from geneSymbol) AK138323 ENSMUST00000173141.1 uc008ckp.1 uc008ckp.2 uc008ckp.1 uc008ckp.2 
ENSMUST00000173157.2 Gm20535 ENSMUST00000173157.2 Gm20535 (from geneSymbol) AK136749 ENSMUST00000173157.1 uc288fij.1 uc288fij.2 uc288fij.1 uc288fij.2 
ENSMUST00000173162.3 Gm20483 ENSMUST00000173162.3 Gm20483 (from geneSymbol) ENSMUST00000173162.1 ENSMUST00000173162.2 uc289koi.1 uc289koi.2 uc289koi.1 uc289koi.2 
ENSMUST00000173165.2 Gm20528 ENSMUST00000173165.2 Gm20528 (from geneSymbol) ENSMUST00000173165.1 uc287kfa.1 uc287kfa.2 uc287kfa.1 uc287kfa.2 
ENSMUST00000173178.4 Gm20420 ENSMUST00000173178.4 Gm20420 (from geneSymbol) AK076648 ENSMUST00000173178.1 ENSMUST00000173178.2 ENSMUST00000173178.3 uc288zpo.1 uc288zpo.2 uc288zpo.3 uc288zpo.1 uc288zpo.2 uc288zpo.3 
ENSMUST00000173185.3 Slc22a13b ENSMUST00000173185.3 Slc22a13b (from geneSymbol) AK079093 ENSMUST00000173185.1 ENSMUST00000173185.2 uc009sam.1 uc009sam.2 uc009sam.3 uc009sam.4 uc009sam.5 uc009sam.1 uc009sam.2 uc009sam.3 uc009sam.4 uc009sam.5 
ENSMUST00000173194.8 Arhgap21 ENSMUST00000173194.8 Rho GTPase activating protein 21, transcript variant 7 (from RefSeq NM_001408323.1) Arhgap21 B7ZCJ0 B7ZCJ0_MOUSE ENSMUST00000173194.1 ENSMUST00000173194.2 ENSMUST00000173194.3 ENSMUST00000173194.4 ENSMUST00000173194.5 ENSMUST00000173194.6 ENSMUST00000173194.7 NM_001408323 uc008imz.1 uc008imz.2 uc008imz.3 Cell junction Cytoplasm, cytoskeleton Cytoplasmic vesicle membrane ; Peripheral membrane protein Golgi apparatus membrane ; Peripheral membrane protein GTPase activator activity signal transduction positive regulation of GTPase activity uc008imz.1 uc008imz.2 uc008imz.3 
ENSMUST00000173208.2 4930515G01Rik ENSMUST00000173208.2 RIKEN cDNA 4930515G01 gene (from RefSeq NR_027872.1) ENSMUST00000173208.1 NR_027872 uc290yqf.1 uc290yqf.2 uc290yqf.1 uc290yqf.2 
ENSMUST00000173246.8 Jarid2 ENSMUST00000173246.8 jumonji and AT-rich interaction domain containing 2, transcript variant 4 (from RefSeq NM_001360281.1) ENSMUST00000173246.1 ENSMUST00000173246.2 ENSMUST00000173246.3 ENSMUST00000173246.4 ENSMUST00000173246.5 ENSMUST00000173246.6 ENSMUST00000173246.7 JARD2_MOUSE Jmj NM_001360281 Q3TPU4 Q3UHS7 Q62315 Q99LD1 uc007qgu.1 uc007qgu.2 uc007qgu.3 Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:10807864, PubMed:12852854, PubMed:12890668, PubMed:15542826, PubMed:15870077, PubMed:19010785, PubMed:20064375, PubMed:20064376, PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20064376, PubMed:20064375). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20064375, PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (PubMed:12852854, PubMed:12890668, PubMed:19010785). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (PubMed:15542826). Participates in the negative regulation of cell proliferation signaling (PubMed:10913339). Does not have histone demethylase activity (PubMed:20064376). Associates with the PRC2 complex, which consists of the core components EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:20064376, PubMed:20064375). Found in a monomeric PRC2.2 (class 2) complex consisting of at least SUZ12, RBBP4, AEBP2 and JARID2 (By similarity). Facilitates nucleosome binding of the PRC2 complex (By similarity). Interacts with SUZ12 (via C2H2-type zinc finger domain); the interaction is direct; competes with EPOP for SUZ12 binding (By similarity). Interacts with histone methyltransferases EHMT1/GLP1 and EHMT2/G9a (By similarity). Interacts with GATA4 (via the N-terminal region) (PubMed:15542826). Interacts with NKX2-5 (via the C- terminal region) (PubMed:15542826). Interacts with RB1 (PubMed:15870077). Interacts with ZNF496 (PubMed:17521633). Interacts with ESRRB (PubMed:26523946). Q62315; Q921E6: Eed; NbExp=11; IntAct=EBI-493592, EBI-904301; Q62315; P70351: Ezh1; NbExp=4; IntAct=EBI-493592, EBI-2531737; Q62315; Q61188: Ezh2; NbExp=15; IntAct=EBI-493592, EBI-904311; Q62315; Q08369: Gata4; NbExp=3; IntAct=EBI-493592, EBI-297008; Q62315; P42582: Nkx2-5; NbExp=3; IntAct=EBI-493592, EBI-297021; Q62315; Q80U70: Suz12; NbExp=13; IntAct=EBI-493592, EBI-2526494; Q62315; Q5SXI5: Znf496; NbExp=6; IntAct=EBI-493592, EBI-7417351; Nucleus te=Colocalizes with the PRC2 complex on chromatin. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q62315-1; Sequence=Displayed; Name=2; IsoId=Q62315-2; Sequence=VSP_038758; Widely expressed in embryos. In adults, expressed at high levels in heart, skeletal muscle, brain and thymus. The ARID domain is required to target the PRC2 complex to its target genes. The GSGFP motif is required for the interaction with SUZ12. Embryos die before 15.5 dpc and show severe cardiac morphological defects and altered heart-specific gene expression. Some, but not all, of the homozygotes develop an abnormal groove in a region just anterior to the midbrain-hindbrain boundary on the neural plate at 8-8.5 dpc and show a defect in neural tube closure in the midbrain region. Variable phenotypes are observed depending on the genetic backgrounds: mutant mice with a C57BL/6J X 129S1/Sv genetic background die upon birth and show cardiac defects such as ventricular septal defects, double-outlet right ventricle, and thin ventricular wall at later embryonic stages. In addition to the thin ventricular wall, mutant embryos with a pure BALB/c background show deficient cell growth in the liver, thymus, and spleen. In contrast, mutant mice with a C3H/He genetic background die at 11.5 dpc, which exhibit hyperplasia and increased cyclin-D1 (CCND1) expression in the trabecular layer of the ventricle at 10.5 dpc. 'Jumonji' means 'cruciform' in Japanese. Belongs to the JARID2 family. Despite the presence of a JmjC domain, lacks the conserved residues that bind the iron cofactor, explaining the absence of histone methyltransferase activity. Sequence=BAE27780.1; Type=Frameshift; Evidence=; Sequence=EDL41007.1; Type=Erroneous gene model prediction; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding liver development DNA binding chromatin binding protein binding nucleus mitochondrion chromatin organization chromatin remodeling multicellular organism development transcription factor binding negative regulation of cell proliferation negative regulation of cardiac muscle hypertrophy histone demethylation cell differentiation negative regulation of histone methylation histone demethylase activity histone H3-K4 demethylation, trimethyl-H3-K4-specific histone methyltransferase complex ESC/E(Z) complex regulation of cell proliferation negative regulation of transcription, DNA-templated spleen development thymus development stem cell differentiation positive regulation of histone H3-K9 methylation negative regulation of cardiac muscle cell proliferation cellular response to leukemia inhibitory factor histone demethylase activity (H3-trimethyl-K4 specific) uc007qgu.1 uc007qgu.2 uc007qgu.3 
ENSMUST00000173249.2 Gm20412 ENSMUST00000173249.2 Gm20412 (from geneSymbol) ENSMUST00000173249.1 uc290ccl.1 uc290ccl.2 uc290ccl.1 uc290ccl.2 
ENSMUST00000173254.8 Banp ENSMUST00000173254.8 BTG3 associated nuclear protein, transcript variant 7 (from RefSeq NM_001413726.1) BANP_MOUSE ENSMUST00000173254.1 ENSMUST00000173254.2 ENSMUST00000173254.3 ENSMUST00000173254.4 ENSMUST00000173254.5 ENSMUST00000173254.6 ENSMUST00000173254.7 NM_001413726 O88973 Q3U4R5 Q8VBU8 Q91YZ1 Q9ES51 Smar1 uc292drr.1 uc292drr.2 Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest and inhibits tumor growth (PubMed:12494467). Interacts with TP53 (PubMed:12494467). Interacts with CUX1/CDP (PubMed:15371550). Interacts with HDAC1 (PubMed:16166625). Part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2 (PubMed:16166625). Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Long; IsoId=Q8VBU8-1; Sequence=Displayed; Name=2; IsoId=Q8VBU8-2; Sequence=VSP_027403; Name=3; Synonyms=Short; IsoId=Q8VBU8-3; Sequence=VSP_027403, VSP_027404; Name=4; IsoId=Q8VBU8-4; Sequence=VSP_027405; Highly expressed in heart, spleen, and thymus. Isoform 1 is highly expressed in kidney, brain and testis. Isoform 3 is highly expressed in kidney and lung. Belongs to the BANP/SMAR1 family. Interaction with TP35 was reported to promotes TP53 'Ser-15' phosphorylation and nuclear accumulation causing cell cycle arrest and inhibition of tumor growth (PubMed:15701641). However, the publication has been retracted due to image duplication and manipulation. Interaction with TP35 has been confirmed by other studies (PubMed:12494467). The nuclear locatization has been confirmed by other studies (PubMed:10940556, PubMed:12494467, PubMed:15371550, PubMed:16166625). p53 binding DNA binding protein binding nucleus nucleoplasm chromatin organization cell cycle multicellular organism development nuclear body protein localization to nucleus negative regulation of protein catabolic process identical protein binding positive regulation of transcription, DNA-templated uc292drr.1 uc292drr.2 
ENSMUST00000173283.3 Zfp977 ENSMUST00000173283.3 zinc finger protein 977 (from RefSeq NM_001362112.1) ENSMUST00000173283.1 ENSMUST00000173283.2 L7N2E7 L7N2E7_MOUSE NM_001362112 Zfp977 uc291oxs.1 uc291oxs.2 uc291oxs.3 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc291oxs.1 uc291oxs.2 uc291oxs.3 
ENSMUST00000173286.8 Otud4 ENSMUST00000173286.8 OTU domain containing 4, transcript variant 2 (from RefSeq NM_001081164.1) A0A0R4J260 A0A0R4J260_MOUSE ENSMUST00000173286.1 ENSMUST00000173286.2 ENSMUST00000173286.3 ENSMUST00000173286.4 ENSMUST00000173286.5 ENSMUST00000173286.6 ENSMUST00000173286.7 NM_001081164 Otud4 uc009mir.1 uc009mir.2 uc009mir.3 Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; uc009mir.1 uc009mir.2 uc009mir.3 
ENSMUST00000173287.8 Adamtsl3 ENSMUST00000173287.8 ADAMTS-like 3 (from RefSeq NM_001190374.1) Adamtsl3 ENSMUST00000173287.1 ENSMUST00000173287.2 ENSMUST00000173287.3 ENSMUST00000173287.4 ENSMUST00000173287.5 ENSMUST00000173287.6 ENSMUST00000173287.7 G3UXC7 G3UXC7_MOUSE NM_001190374 uc009ida.1 uc009ida.2 uc009ida.3 uc009ida.4 molecular_function proteolysis biological_process peptidase activity intracellular membrane-bounded organelle uc009ida.1 uc009ida.2 uc009ida.3 uc009ida.4 
ENSMUST00000173293.2 Gm9921 ENSMUST00000173293.2 Gm9921 (from geneSymbol) AK082156 ENSMUST00000173293.1 uc288ger.1 uc288ger.2 uc288ger.1 uc288ger.2 
ENSMUST00000173304.2 Gm20394 ENSMUST00000173304.2 Gm20394 (from geneSymbol) ENSMUST00000173304.1 uc288cdg.1 uc288cdg.2 uc288cdg.1 uc288cdg.2 
ENSMUST00000173320.8 Wdr81 ENSMUST00000173320.8 WD repeat domain 81 (from RefSeq NM_138950.2) ENSMUST00000173320.1 ENSMUST00000173320.2 ENSMUST00000173320.3 ENSMUST00000173320.4 ENSMUST00000173320.5 ENSMUST00000173320.6 ENSMUST00000173320.7 G5E8V0 NM_138950 Q3TA90 Q3TUS9 Q5ND34 Q6KAR1 WDR81_MOUSE Wdr81 uc011xzj.1 uc011xzj.2 uc011xzj.3 Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3- phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (By similarity). May also be involved in maintenance of normal mitochondrial structure and organization (PubMed:23595742). Interacts with WDR91; involved in early to late endosome cargo transport. Interacts with BECN1; negatively regulates the PI3 kinase/PI3K activity associated with endosomal membranes. Interacts with SQSTM1; the interaction is direct and regulates the interaction of SQSTM1 with ubiquitinated proteins. Interacts with MAP1LC3C; recruits MAP1LC3C to ubiquitinated protein aggregates in the aggrephagy process. Early endosome membrane ; Peripheral membrane protein Late endosome membrane Lysosome membrane Cytoplasmic vesicle, autophagosome membrane Mitochondrion Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5ND34-1; Sequence=Displayed; Name=2; IsoId=Q5ND34-2; Sequence=VSP_019956; Name=3; IsoId=Q5ND34-3; Sequence=VSP_019957; Expressed in brain, Purkinje cells of cerebellum, retinal photoreceptor cells and spinal cord (at protein level) (PubMed:23595742). In brain, specifically expressed by neuronal cells (at protein level). Detected in a wide range of tissues including intestine, adipose tissue, liver, pancreas, thymus, spleen, kidney, heart, eye, sciatic nerve, and testis (PubMed:21885617, PubMed:23595742, PubMed:28404643). Brain-specific, conditional knockout mice are born at the expected Mendelian frequency, but most of them die a few hours after birth. If they show no overt brain morphological abnormalities, a neuronal accumulation of SQSTM1 in foci is observed. Belongs to the WD repeat WDR81 family. Sequence=BAD21396.1; Type=Erroneous translation; Note=Incomplete prediction of CDS at the C-terminus.; Evidence=; autophagosome membrane cytoplasm mitochondrion lysosome lysosomal membrane endosome cytosol ubiquitin-dependent protein catabolic process mitochondrion organization negative regulation of phosphatase activity membrane extrinsic component of endosome membrane cytoplasmic vesicle early endosome membrane late endosome membrane phosphatidylinositol 3-kinase regulator activity aggrephagy regulation of phosphatidylinositol 3-kinase activity early endosome to late endosome transport protein stabilization K63-linked polyubiquitin binding uc011xzj.1 uc011xzj.2 uc011xzj.3 
ENSMUST00000173324.8 Aif1 ENSMUST00000173324.8 allograft inflammatory factor 1, transcript variant 2 (from RefSeq NM_019467.4) Aif1 ENSMUST00000173324.1 ENSMUST00000173324.2 ENSMUST00000173324.3 ENSMUST00000173324.4 ENSMUST00000173324.5 ENSMUST00000173324.6 ENSMUST00000173324.7 NM_019467 Q4FJL9 Q4FJL9_MOUSE uc008cgm.1 uc008cgm.2 Cell projection, phagocytic cup Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton positive regulation of protein phosphorylation calcium ion binding nucleus cytoplasm cytosol actin filament inflammatory response positive regulation of cell proliferation negative regulation of gene expression positive regulation of muscle hyperplasia cerebellum development lamellipodium actin filament polymerization positive regulation of cell migration cellular response to extracellular stimulus ruffle membrane cellular response to hormone stimulus response to cytokine cellular response to oxidative stress positive regulation of T cell proliferation cell projection negative regulation of apoptotic process perikaryon positive regulation of nitric oxide biosynthetic process perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation response to axon injury positive regulation of chemotaxis actin filament binding actin filament bundle assembly response to glucocorticoid response to electrical stimulus cellular response to morphine cellular response to interferon-gamma cellular response to hydroperoxide negative regulation of smooth muscle cell chemotaxis positive regulation of smooth muscle cell chemotaxis positive regulation of mononuclear cell migration positive regulation of monocyte chemotaxis positive regulation of chemokine secretion positive regulation of fibroblast growth factor production positive regulation of G1/S transition of mitotic cell cycle positive regulation of T cell migration positive regulation of interleukin-6 secretion uc008cgm.1 uc008cgm.2 
ENSMUST00000173333.3 ENSMUSG00000121344 ENSMUST00000173333.3 ENSMUSG00000121344 (from geneSymbol) ENSMUST00000173333.1 ENSMUST00000173333.2 uc289kdk.1 uc289kdk.2 uc289kdk.3 uc289kdk.1 uc289kdk.2 uc289kdk.3 
ENSMUST00000173341.9 Gtf2i ENSMUST00000173341.9 general transcription factor II I, transcript variant 5 (from RefSeq NM_001080749.2) ENSMUST00000173341.1 ENSMUST00000173341.2 ENSMUST00000173341.3 ENSMUST00000173341.4 ENSMUST00000173341.5 ENSMUST00000173341.6 ENSMUST00000173341.7 ENSMUST00000173341.8 Gtf2i NM_001080749 Q3UHU8 Q3UHU8_MOUSE uc008zvq.1 uc008zvq.2 uc008zvq.3 uc008zvq.4 uc008zvq.5 Nucleus transcription factor activity, sequence-specific DNA binding regulation of transcription, DNA-templated transcription from RNA polymerase II promoter uc008zvq.1 uc008zvq.2 uc008zvq.3 uc008zvq.4 uc008zvq.5 
ENSMUST00000173348.2 Nkx1-1 ENSMUST00000173348.2 NK1 homeobox 1 (from RefSeq NM_011320.1) A0A8Q0Q4F2 A0A8Q0Q4F2_MOUSE ENSMUST00000173348.1 NM_011320 Nkx1-1 uc290une.1 uc290une.2 Nucleus uc290une.1 uc290une.2 
ENSMUST00000173374.2 Gm20457 ENSMUST00000173374.2 Gm20457 (from geneSymbol) ENSMUST00000173374.1 uc291qyx.1 uc291qyx.2 uc291qyx.1 uc291qyx.2 
ENSMUST00000173393.8 Rbm38 ENSMUST00000173393.8 RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- IIIb, an epithelial cell-specific isoform of FGFR2 (By similarity). Plays a role in myogenic differentiation. (from UniProt Q62176) BC006687 ENSMUST00000173393.1 ENSMUST00000173393.2 ENSMUST00000173393.3 ENSMUST00000173393.4 ENSMUST00000173393.5 ENSMUST00000173393.6 ENSMUST00000173393.7 Q5U418 Q62176 Q922Z2 RBM38_MOUSE Rnpc1 Seb4 Seb4l uc008odh.1 uc008odh.2 uc008odh.3 uc008odh.4 RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- IIIb, an epithelial cell-specific isoform of FGFR2 (By similarity). Plays a role in myogenic differentiation. Cytoplasm, cytosol Nucleus Expressed in cardiac and skeletal muscle tissues. Belongs to the RBM38 family. It is uncertain whether Met-1 or Met-22 is the initiator. nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding nucleus cytoplasm cytosol mRNA processing DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cell cycle negative regulation of cell proliferation RNA splicing regulation of myotube differentiation cell differentiation regulation of RNA splicing 3'-UTR-mediated mRNA stabilization ribonucleoprotein complex uc008odh.1 uc008odh.2 uc008odh.3 uc008odh.4 
ENSMUST00000173397.8 Dnm2 ENSMUST00000173397.8 dynamin 2, transcript variant 2 (from RefSeq NM_001039520.2) Dnm2 ENSMUST00000173397.1 ENSMUST00000173397.2 ENSMUST00000173397.3 ENSMUST00000173397.4 ENSMUST00000173397.5 ENSMUST00000173397.6 ENSMUST00000173397.7 NM_001039520 Q3TCR7 Q3TCR7_MOUSE uc009olj.1 uc009olj.2 uc009olj.3 uc009olj.4 Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5; Evidence=; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. nucleotide binding GTPase activity GTP binding microtubule endocytosis uc009olj.1 uc009olj.2 uc009olj.3 uc009olj.4 
ENSMUST00000173420.2 Art2a ENSMUST00000173420.2 ADP-ribosyltransferase 2a, transcript variant 1, non-coding (from RefSeq NR_033804.2) ENSMUST00000173420.1 NR_033804 uc012fqm.1 uc012fqm.2 uc012fqm.3 uc012fqm.1 uc012fqm.2 uc012fqm.3 
ENSMUST00000173432.3 Hoxb6 ENSMUST00000173432.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (from UniProt P09023) AK011622 ENSMUST00000173432.1 ENSMUST00000173432.2 HXB6_MOUSE Hox-2.2 Hoxb-6 P09023 uc007lbt.1 uc007lbt.2 uc007lbt.3 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. P09023; P41778: Pbx1; NbExp=2; IntAct=EBI-15992861, EBI-6996259; Nucleus. Belongs to the Antp homeobox family. RNA polymerase II distal enhancer sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification erythrocyte homeostasis sequence-specific DNA binding embryonic skeletal system morphogenesis embryonic skeletal system development uc007lbt.1 uc007lbt.2 uc007lbt.3 
ENSMUST00000173433.8 Baz1a ENSMUST00000173433.8 bromodomain adjacent to zinc finger domain 1A (from RefSeq NM_013815.2) Baz1a ENSMUST00000173433.1 ENSMUST00000173433.2 ENSMUST00000173433.3 ENSMUST00000173433.4 ENSMUST00000173433.5 ENSMUST00000173433.6 ENSMUST00000173433.7 G3UWZ0 G3UWZ0_MOUSE NM_013815 uc007nnz.1 uc007nnz.2 uc007nnz.3 uc007nnz.4 Nucleus nucleus DNA-dependent DNA replication chromatin remodeling CHRAC metal ion binding uc007nnz.1 uc007nnz.2 uc007nnz.3 uc007nnz.4 
ENSMUST00000173456.8 Vdac2 ENSMUST00000173456.8 Membrane Mitochondrion outer membrane (from UniProt G3UX26) AK012359 ENSMUST00000173456.1 ENSMUST00000173456.2 ENSMUST00000173456.3 ENSMUST00000173456.4 ENSMUST00000173456.5 ENSMUST00000173456.6 ENSMUST00000173456.7 G3UX26 G3UX26_MOUSE Vdac2 uc288rlc.1 uc288rlc.2 Membrane Mitochondrion outer membrane Belongs to the eukaryotic mitochondrial porin family. mitochondrial outer membrane voltage-gated anion channel activity inorganic anion transport transmembrane transport anion transmembrane transport uc288rlc.1 uc288rlc.2 
ENSMUST00000173459.3 Vmn2r34 ENSMUST00000173459.3 vomeronasal 2, receptor 34 (from RefSeq NM_001105066.1) E9PVI0 E9PVI0_MOUSE ENSMUST00000173459.1 ENSMUST00000173459.2 NM_001105066 Vmn2r34 Vmn2r45 uc012exv.1 uc012exv.2 uc012exv.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012exv.1 uc012exv.2 uc012exv.3 
ENSMUST00000173462.3 Scnm1 ENSMUST00000173462.3 As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:17656373, PubMed:12920299). Plays a role in the regulation of primary cilia length and Hedgehog signaling (By similarity). (from UniProt Q8K136) AK013948 ENSMUST00000173462.1 ENSMUST00000173462.2 Q8K136 Q9CXV5 SCNM1_MOUSE Scnm1-ps uc012ctr.1 uc012ctr.2 uc012ctr.3 As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:17656373, PubMed:12920299). Plays a role in the regulation of primary cilia length and Hedgehog signaling (By similarity). Component of the minor spliceosome (PubMed:17656373). Within this complex, interacts with RNF113A, as well as with SF3B1/SF3b155, SF3B2/SF3b145, SF3B3/SF3b130 and CDC5L (By similarity). May interact with LUC7L2 and SNRNP70 (PubMed:17656373). Nucleus, nucleoplasm Nucleus speckle Note=Colocalizes with LUC7L2 and SNRNP70 in nuclear speckles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K136-1; Sequence=Displayed; Name=3; IsoId=Q8K136-3; Sequence=VSP_021490; Strains C57BL/6J, C57BR/cdJ, C57L/J, C57BL/10J and C58/J carry the R187X allele, in which a polymorphism generates a premature stop codon, leading to either a truncated protein or an alternatively spliced isoform 3. Note=Allele R187X is a disease susceptibility variant, which modifies the severity of the disease jolting mutant (medjo) caused by defects in Scn8a. It reduces the abundance of correctly spliced Scn8a transcripts below the threshold for survival thereby converting a chronic movement disorder into a lethal neurological disease. [Isoform 3]: Due to disruption of a consensus exonic splicing enhancer in allele R187X, leading to exon 6 skipping. Only found in strains C57BL/6J, C57BR/cdJ, C57L/J, C57BL/10J and C58/J. alternative mRNA splicing, via spliceosome nucleus nucleoplasm mRNA processing RNA splicing nuclear speck enzyme binding metal ion binding uc012ctr.1 uc012ctr.2 uc012ctr.3 
ENSMUST00000173472.3 Or12d13 ENSMUST00000173472.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q920Y8) ENSMUST00000173472.1 ENSMUST00000173472.2 Olfr103 Or12d13 Q920Y8 Q920Y8_MOUSE uc289kza.1 uc289kza.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kza.1 uc289kza.2 
ENSMUST00000173478.2 Ly6g6c ENSMUST00000173478.2 lymphocyte antigen 6 family member G6C (from RefSeq NM_023463.3) ENSMUST00000173478.1 LY66C_MOUSE NM_023463 Ng24 Q9Z1Q4 uc008cfm.1 uc008cfm.2 uc008cfm.3 Monomer. Cell membrane ; Lipid-anchor, GPI- anchor Highly expressed at the leading edges of cells, on filopodia. N-glycosylated. plasma membrane response to bacterium external side of plasma membrane membrane anchored component of membrane macromolecular complex identical protein binding protein homooligomerization uc008cfm.1 uc008cfm.2 uc008cfm.3 
ENSMUST00000173484.2 Gm16451 ENSMUST00000173484.2 predicted pseudogene 16451 (from RefSeq NM_001167149.1) D3YZG3 D3YZG3_MOUSE ENSMUST00000173484.1 Gm16442 Gm16451 NM_001167149 Vmn1r240 uc012fdr.1 uc012fdr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fdr.1 uc012fdr.2 
ENSMUST00000173492.9 Kifc1 ENSMUST00000173492.9 kinesin family member C1, transcript variant 6 (from RefSeq NR_177090.1) ENSMUST00000173492.1 ENSMUST00000173492.2 ENSMUST00000173492.3 ENSMUST00000173492.4 ENSMUST00000173492.5 ENSMUST00000173492.6 ENSMUST00000173492.7 ENSMUST00000173492.8 KIFC1_MOUSE Kifc1 Kifc4 Kifc5a Kifc5b NR_177090 O08671 O35230 Q497Y3 Q4A1N2 Q6PG90 Q8BV06 Q99L84 Q9JKZ0 Q9QWT9 uc008bzw.1 uc008bzw.2 uc008bzw.3 uc008bzw.4 Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:16638812). May contribute to movement of early endocytic vesicles (PubMed:17360972). Regulates cilium formation and structure (PubMed:23807208). Binds NUBP1 and NUBP2 (PubMed:16638812). Interacts with PPP1R42 (PubMed:18237440). Nucleus toplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle rly endosome Note=Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis. Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q9QWT9-1; Sequence=Displayed; Name=2 ; IsoId=Q9QWT9-2; Sequence=VSP_052526; Name=3 ; IsoId=Q9QWT9-3; Sequence=VSP_052526, VSP_052527; Highly expressed in 14 dpc embryos, spleen and NIH3T3 cells. Also expressed in testis, brain, lung, kidney and cultured astrocytes. Very low levels in skeletal muscle and heart. Highly expressed in hippocampus of 13 dpc embryos declining to low levels by 18 dpc and to undetectable levels in juvenile and adult hippocampus. Centrosome amplification as well as multipolar spindles. Cells overexpressing Kifc1 show a single microtubule aster and growth arrest in prometaphase. Purified early endocytic vesicles bind minus end- directed Kifc1 as well as plus end-directed Kif5b. Addition of anti- Kifc1 antibodies leads to a decrease in minus end-directed vesicle motility in vitro. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily. Sequence=BAA19676.1; Type=Frameshift; Evidence=; nucleotide binding microtubule motor activity protein binding ATP binding nucleus cytoplasm endosome early endosome microtubule organizing center spindle cytoskeleton kinesin complex microtubule microtubule-based movement cell cycle mitotic metaphase plate congression microtubule binding ATP-dependent microtubule motor activity, minus-end-directed negative regulation of centrosome duplication ATPase activity endocytic vesicle spindle pole centrosome vesicle transport along microtubule cell division minus-end-directed vesicle transport along microtubule mitotic spindle mitotic spindle assembly uc008bzw.1 uc008bzw.2 uc008bzw.3 uc008bzw.4 
ENSMUST00000173494.4 Ak9 ENSMUST00000173494.4 adenylate kinase 9 (from RefSeq NM_001370813.1) Ak9 Akd1 ENSMUST00000173494.1 ENSMUST00000173494.2 ENSMUST00000173494.3 G3UYQ4 G3UYQ4_MOUSE NM_001370813 uc287qry.1 uc287qry.2 nucleoside diphosphate kinase activity ATP binding nucleus nucleoplasm cytoplasm nucleobase-containing compound metabolic process dADP phosphorylation dGDP phosphorylation AMP phosphorylation ATP generation from ADP nucleobase-containing compound kinase activity nuclear membrane nucleoside phosphate kinase activity CDP phosphorylation dAMP phosphorylation CMP phosphorylation dCMP phosphorylation GDP phosphorylation UDP phosphorylation dCDP phosphorylation TDP phosphorylation uc287qry.1 uc287qry.2 
ENSMUST00000173495.8 Mecom ENSMUST00000173495.8 Nucleus (from UniProt G3UZT5) BC076620 ENSMUST00000173495.1 ENSMUST00000173495.2 ENSMUST00000173495.3 ENSMUST00000173495.4 ENSMUST00000173495.5 ENSMUST00000173495.6 ENSMUST00000173495.7 G3UZT5 G3UZT5_MOUSE Mecom uc290egm.1 uc290egm.2 Nucleus nucleic acid binding uc290egm.1 uc290egm.2 
ENSMUST00000173512.2 Gm20441 ENSMUST00000173512.2 Belongs to the MIF family. (from UniProt G3UYJ7) BC003903 ENSMUST00000173512.1 G3UYJ7 G3UYJ7_MOUSE Gm20441 uc287sgu.1 uc287sgu.2 Belongs to the MIF family. glutathione transferase activity glutathione metabolic process uc287sgu.1 uc287sgu.2 
ENSMUST00000173522.8 Sdr42e1 ENSMUST00000173522.8 short chain dehydrogenase/reductase family 42E, member 1, transcript variant 2 (from RefSeq NM_001357273.1) D42E1_MOUSE ENSMUST00000173522.1 ENSMUST00000173522.2 ENSMUST00000173522.3 ENSMUST00000173522.4 ENSMUST00000173522.5 ENSMUST00000173522.6 ENSMUST00000173522.7 NM_001357273 Q8VCV0 Q9D665 uc009npe.1 uc009npe.2 uc009npe.3 Membrane ; Multi-pass membrane protein Belongs to the 3-beta-HSD family. Sequence=AAH18550.1; Type=Erroneous initiation; Evidence=; 3-beta-hydroxy-delta5-steroid dehydrogenase activity cellular_component steroid biosynthetic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidation-reduction process uc009npe.1 uc009npe.2 uc009npe.3 
ENSMUST00000173533.2 Ptger3 ENSMUST00000173533.2 prostaglandin E receptor 3 (subtype EP3), transcript variant 1 (from RefSeq NM_001359745.2) ENSMUST00000173533.1 G3UYL9 G3UYL9_MOUSE NM_001359745 Ptger3 uc008rvi.1 uc008rvi.2 uc008rvi.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity prostaglandin receptor activity prostaglandin E receptor activity G-protein coupled receptor signaling pathway membrane integral component of membrane uc008rvi.1 uc008rvi.2 uc008rvi.3 
ENSMUST00000173620.2 A930009A15Rik ENSMUST00000173620.2 RIKEN cDNA A930009A15 gene, transcript variant 1 (from RefSeq NM_029982.1) A930009A15Rik ENSMUST00000173620.1 G3UYI6 G3UYI6_MOUSE NM_029982 uc007hbl.1 uc007hbl.2 uc007hbl.3 uc007hbl.4 molecular_function cellular_component biological_process uc007hbl.1 uc007hbl.2 uc007hbl.3 uc007hbl.4 
ENSMUST00000173622.2 Gm20490 ENSMUST00000173622.2 Gm20490 (from geneSymbol) ENSMUST00000173622.1 uc290cyk.1 uc290cyk.2 uc290cyk.1 uc290cyk.2 
ENSMUST00000173623.2 Evx2 ENSMUST00000173623.2 even-skipped homeobox 2 (from RefSeq NM_007967.3) ENSMUST00000173623.1 EVX2_MOUSE Evx-2 NM_007967 P49749 uc289xak.1 uc289xak.2 This gene is located at the 5' end of the Hoxd gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. The encoded protein plays a role in limb morphogenesis. [provided by RefSeq, Aug 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M93128.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849389, SAMN01164133 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Nucleus. Belongs to the even-skipped homeobox family. DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development limb morphogenesis sequence-specific DNA binding uc289xak.1 uc289xak.2 
ENSMUST00000173637.3 4931413I07Rik ENSMUST00000173637.3 4931413I07Rik (from geneSymbol) AK016453 ENSMUST00000173637.1 ENSMUST00000173637.2 uc289jwi.1 uc289jwi.2 uc289jwi.3 uc289jwi.1 uc289jwi.2 uc289jwi.3 
ENSMUST00000173655.8 Cpsf4l ENSMUST00000173655.8 cleavage and polyadenylation specific factor 4-like, transcript variant 1 (from RefSeq NM_026682.2) Cpsf4l ENSMUST00000173655.1 ENSMUST00000173655.2 ENSMUST00000173655.3 ENSMUST00000173655.4 ENSMUST00000173655.5 ENSMUST00000173655.6 ENSMUST00000173655.7 G3UWW6 G3UWW6_MOUSE NM_026682 uc007mez.1 uc007mez.2 uc007mez.3 uc007mez.4 Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). Component of the cleavage and polyadenylation specificity factor (CPSF) complex. Nucleus Belongs to the CPSF4/YTH1 family. mRNA cleavage and polyadenylation specificity factor complex metal ion binding pre-mRNA cleavage required for polyadenylation uc007mez.1 uc007mez.2 uc007mez.3 uc007mez.4 
ENSMUST00000173672.4 Neat1 ENSMUST00000173672.4 nuclear paraspeckle assembly transcript 1 (non-protein coding), transcript variant MENbeta (from RefSeq NR_131212.1) ENSMUST00000173672.1 ENSMUST00000173672.2 ENSMUST00000173672.3 NR_131212 uc012bhe.1 uc012bhe.2 uc012bhe.3 uc012bhe.4 uc012bhe.5 uc012bhe.6 uc012bhe.7 This gene produces a long non-coding RNA (lncRNA) that is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]. uc012bhe.1 uc012bhe.2 uc012bhe.3 uc012bhe.4 uc012bhe.5 uc012bhe.6 uc012bhe.7 
ENSMUST00000173677.2 4930556N13Rik ENSMUST00000173677.2 RIKEN cDNA 4930556N13 gene (from RefSeq NR_126433.1) ENSMUST00000173677.1 NR_126433 uc056yoc.1 uc056yoc.2 uc056yoc.1 uc056yoc.2 
ENSMUST00000173680.2 Gm20481 ENSMUST00000173680.2 Gm20481 (from geneSymbol) ENSMUST00000173680.1 uc289kja.1 uc289kja.2 uc289kja.1 uc289kja.2 
ENSMUST00000173683.2 Gm20529 ENSMUST00000173683.2 Gm20529 (from geneSymbol) ENSMUST00000173683.1 uc292lbg.1 uc292lbg.2 uc292lbg.1 uc292lbg.2 
ENSMUST00000173689.8 Jmjd1c ENSMUST00000173689.8 jumonji domain containing 1C, transcript variant 2 (from RefSeq NM_001242396.1) E9QMM8 ENSMUST00000173689.1 ENSMUST00000173689.2 ENSMUST00000173689.3 ENSMUST00000173689.4 ENSMUST00000173689.5 ENSMUST00000173689.6 ENSMUST00000173689.7 JHD2C_MOUSE Jhdm2c Kiaa1380 NM_001242396 Q69ZK6 Q6NV48 Q8BUF5 Q8C4I5 Q8C5Q9 uc007fls.1 uc007fls.2 uc007fls.3 uc007fls.4 Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Nucleus Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors. Belongs to the JHDM2 histone demethylase family. Sequence=AAH68318.1; Type=Frameshift; Evidence=; Sequence=AAH68318.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; Sequence=BAC36783.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC38410.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAD32440.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; chromatin transcription regulatory region sequence-specific DNA binding epithelial cell morphogenesis nucleus chromatin organization male gonad development oxidoreductase activity chromatin DNA binding histone demethylase activity (H3-K9 specific) histone H3-K9 demethylation male germ-line stem cell population maintenance metal ion binding dioxygenase activity oxidation-reduction process seminiferous tubule development maintenance of cell number reproductive senescence uc007fls.1 uc007fls.2 uc007fls.3 uc007fls.4 
ENSMUST00000173695.3 Gm20400 ENSMUST00000173695.3 Gm20400 (from geneSymbol) ENSMUST00000173695.1 ENSMUST00000173695.2 uc291kae.1 uc291kae.2 uc291kae.3 uc291kae.1 uc291kae.2 uc291kae.3 
ENSMUST00000173707.2 2410137M14Rik ENSMUST00000173707.2 Involved in the presentation of foreign antigens to the immune system. (from UniProt G3UXK3) 2410137M14Rik BC171992 ENSMUST00000173707.1 G3UXK3 G3UXK3_MOUSE uc289kwp.1 uc289kwp.2 Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. molecular_function cellular_component biological_process uc289kwp.1 uc289kwp.2 
ENSMUST00000173723.2 Vmn1r113 ENSMUST00000173723.2 vomeronasal 1 receptor 113 (from RefSeq NM_001166716.1) ENSMUST00000173723.1 G3UWI8 G3UWI8_MOUSE NM_001166716 Vmn1r113 uc012fcn.1 uc012fcn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fcn.1 uc012fcn.2 
ENSMUST00000173727.8 Lig3 ENSMUST00000173727.8 ligase III, DNA, ATP-dependent, transcript variant 9 (from RefSeq NM_001403860.1) ENSMUST00000173727.1 ENSMUST00000173727.2 ENSMUST00000173727.3 ENSMUST00000173727.4 ENSMUST00000173727.5 ENSMUST00000173727.6 ENSMUST00000173727.7 Lig3 NM_001403860 Q3UC82 Q3UC82_MOUSE uc007knb.1 uc007knb.2 uc007knb.3 uc007knb.4 Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.; EC=6.5.1.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Nucleus Belongs to the ATP-dependent DNA ligase family. nucleotide binding DNA binding DNA ligase activity DNA ligase (ATP) activity ATP binding DNA replication DNA repair DNA recombination cellular response to DNA damage stimulus zinc ion binding ligase activity DNA ligation involved in DNA repair DNA biosynthetic process uc007knb.1 uc007knb.2 uc007knb.3 uc007knb.4 
ENSMUST00000173770.3 Gm20496 ENSMUST00000173770.3 Gm20496 (from geneSymbol) ENSMUST00000173770.1 ENSMUST00000173770.2 uc289kch.1 uc289kch.2 uc289kch.1 uc289kch.2 
ENSMUST00000173799.2 Gm20395 ENSMUST00000173799.2 Gm20395 (from geneSymbol) ENSMUST00000173799.1 uc289sdl.1 uc289sdl.2 uc289sdl.1 uc289sdl.2 
ENSMUST00000173801.8 Syncrip ENSMUST00000173801.8 synaptotagmin binding, cytoplasmic RNA interacting protein, transcript variant 1 (from RefSeq NM_019666.2) ENSMUST00000173801.1 ENSMUST00000173801.2 ENSMUST00000173801.3 ENSMUST00000173801.4 ENSMUST00000173801.5 ENSMUST00000173801.6 ENSMUST00000173801.7 HNRPQ_MOUSE Hnrpq NM_019666 Nsap1 Nsap1l O88991 Q2YDV8 Q68ED6 Q7TMK9 Q80YV6 Q8BGP1 Q8C5K6 Q8CGC2 Q91ZR0 Q99KU9 Q9QYF4 uc009qyr.1 uc009qyr.2 uc009qyr.3 Heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1 and isoform 2 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences (By similarity). Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself (By similarity). May be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 2 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Identified in the spliceosome C complex. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, YBX1 and untranslated mRNAs. Interacts with GTPBP1 (By similarity). Isoform 1 is a component of the APOB mRNA editosome complex. Isoform 1 interacts with APOBEC1 and A1CF. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR, HNRPD and SYNCRIP. Isoform 2 interacts with HNRPR. Interacts with POLR2A hyperphosphorylated C-terminal domain. Interacts with HABP4 (By similarity). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Isoform 1 and isoform 2 interact with SMN. Isoform 2 interacts through its C-terminal domain with SYT7, SYT8 and SYT9. The non- phosphorylated and phosphorylated forms are colocalized with PAIP1 in polysomes. Nucleus cleus, nucleoplasm Microsome Cytoplasm Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). Isoforms 1 and 2 are expressed predominantly in the nucleoplasm. According to PubMed:10734137, isoform 2 is predominantly found in cytoplasm. The tyrosine phosphorylated form bound to RNA is found in microsomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TMK9-1; Sequence=Displayed; Name=2; IsoId=Q7TMK9-2; Sequence=VSP_009585, VSP_009586; Ubiquitous. Detected in heart, brain, spleen, lung, liver, skeletal muscle, adipocytes, kidney and testis. Expressed in spinal cord at 14 dpc and onwards. The domain containing eight Arg-Gly-Gly repeats (RGG/RXR-box) may be involved in RNA-binding and protein-protein interactions. It is methylated by PRMT1, and essential for nuclear localization (By similarity). Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA, whereas the cytoplasmic form is poorly phosphorylated. [Isoform 2]: May be due to a competing donor splice site and to an exon inclusion. Sequence=AAH55863.1; Type=Erroneous initiation; Evidence=; Sequence=AAH58807.1; Type=Erroneous initiation; Evidence=; nucleic acid binding RNA binding mRNA binding nucleus nucleoplasm spliceosomal complex cytoplasm endoplasmic reticulum mRNA processing poly(A) binding RNA splicing negative regulation of translation intracellular membrane-bounded organelle mRNA 5'-UTR binding CRD-mediated mRNA stabilization CRD-mediated mRNA stability complex catalytic step 2 spliceosome histone pre-mRNA 3'end processing complex cellular response to interferon-gamma GAIT complex ribonucleoprotein complex uc009qyr.1 uc009qyr.2 uc009qyr.3 
ENSMUST00000173804.8 Gprasp2 ENSMUST00000173804.8 G protein-coupled receptor associated sorting protein 2, transcript variant 1 (from RefSeq NM_001163015.2) ENSMUST00000173804.1 ENSMUST00000173804.2 ENSMUST00000173804.3 ENSMUST00000173804.4 ENSMUST00000173804.5 ENSMUST00000173804.6 ENSMUST00000173804.7 GASP2_MOUSE NM_001163015 Q148X7 Q8BUY8 uc009uht.1 uc009uht.2 uc009uht.3 May play a role in regulation of a variety of G-protein coupled receptors. Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR. Strongly expressed in the brain and the cochlea. Also in lung and muscle tissues. Localized in multiple structures of the cochlea, detected in the spiral ganglion, stria vascularis, spiral ligament, inner and outer hair cells. Belongs to the GPRASP family. beta-amyloid binding G-protein coupled receptor binding nucleus cytoplasm biological_process uc009uht.1 uc009uht.2 uc009uht.3 
ENSMUST00000173815.9 Vmn2r-ps158 ENSMUST00000173815.9 vomeronasal 2, receptor, pseudogene 158 (from RefSeq NR_169589.1) ENSMUST00000173815.1 ENSMUST00000173815.2 ENSMUST00000173815.3 ENSMUST00000173815.4 ENSMUST00000173815.5 ENSMUST00000173815.6 ENSMUST00000173815.7 ENSMUST00000173815.8 G3UZC7 G3UZC7_MOUSE Gm9268 NR_169589 Vmn2r-ps158 Vmn2r126 uc012fjb.1 uc012fjb.2 uc012fjb.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012fjb.1 uc012fjb.2 uc012fjb.3 
ENSMUST00000173816.5 Vmn1r180 ENSMUST00000173816.5 vomeronasal 1 receptor 180 (from RefSeq NM_206869.2) B9EK86 B9EK86_MOUSE ENSMUST00000173816.1 ENSMUST00000173816.2 ENSMUST00000173816.3 ENSMUST00000173816.4 NM_206869 V1rd16 Vmn1r180 uc009fon.1 uc009fon.2 uc009fon.3 uc009fon.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009fon.1 uc009fon.2 uc009fon.3 uc009fon.4 
ENSMUST00000173825.4 Obox4-ps35 ENSMUST00000173825.4 Obox4-ps35 (from geneSymbol) ENSMUST00000173825.1 ENSMUST00000173825.2 ENSMUST00000173825.3 uc291lyn.1 uc291lyn.2 uc291lyn.1 uc291lyn.2 
ENSMUST00000173840.3 Gm20443 ENSMUST00000173840.3 Gm20443 (from geneSymbol) ENSMUST00000173840.1 ENSMUST00000173840.2 uc289kpo.1 uc289kpo.2 uc289kpo.3 uc289kpo.1 uc289kpo.2 uc289kpo.3 
ENSMUST00000173841.3 Or2n1e ENSMUST00000173841.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRI7) ENSMUST00000173841.1 ENSMUST00000173841.2 G3UXU4 Olfr138 Or2n1e Q7TRI7 Q7TRI7_MOUSE uc289lbx.1 uc289lbx.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lbx.1 uc289lbx.2 
ENSMUST00000173847.2 Dtnbos ENSMUST00000173847.2 Dtnbos (from geneSymbol) AK148460 ENSMUST00000173847.1 uc288eor.1 uc288eor.2 uc288eor.1 uc288eor.2 
ENSMUST00000173852.2 Ppp1r2-ps9 ENSMUST00000173852.2 protein phosphatase 1, regulatory (inhibitor) subunit 2, pseudogene 9 (from RefSeq NR_033171.1) ENSMUST00000173852.1 NR_033171 uc292nib.1 uc292nib.2 uc292nib.1 uc292nib.2 
ENSMUST00000173867.8 Cct4 ENSMUST00000173867.8 chaperonin containing TCP1 subunit 4 (from RefSeq NM_009837.1) Cct4 ENSMUST00000173867.1 ENSMUST00000173867.2 ENSMUST00000173867.3 ENSMUST00000173867.4 ENSMUST00000173867.5 ENSMUST00000173867.6 ENSMUST00000173867.7 NM_009837 Q564F4 Q564F4_MOUSE uc007ieo.1 uc007ieo.2 uc007ieo.3 Cytoplasm Belongs to the TCP-1 chaperonin family. nucleotide binding ATP binding nucleoplasm cytoplasm centrosome cytosol chaperonin-containing T-complex microtubule protein folding positive regulation of telomere maintenance via telomerase protein stabilization unfolded protein binding positive regulation of telomerase activity scaRNA localization to Cajal body positive regulation of establishment of protein localization to telomere positive regulation of telomerase RNA localization to Cajal body uc007ieo.1 uc007ieo.2 uc007ieo.3 
ENSMUST00000173875.9 Sra1 ENSMUST00000173875.9 steroid receptor RNA activator 1, transcript variant 1 (from RefSeq NM_025291.3) A0A8Q0Q6H9 A0A8Q0Q6H9_MOUSE ENSMUST00000173875.1 ENSMUST00000173875.2 ENSMUST00000173875.3 ENSMUST00000173875.4 ENSMUST00000173875.5 ENSMUST00000173875.6 ENSMUST00000173875.7 ENSMUST00000173875.8 NM_025291 Sra1 uc008eny.1 uc008eny.2 uc008eny.3 uc008eny.4 uc008eny.5 uc008eny.1 uc008eny.2 uc008eny.3 uc008eny.4 uc008eny.5 
ENSMUST00000173886.2 Vmn1r245 ENSMUST00000173886.2 vomeronasal 1 receptor 245 (from RefSeq NM_001167146.1) ENSMUST00000173886.1 Gm5726 Gm8677 K9J7G9 K9J7G9_MOUSE NM_001167146 Vmn1r245 Vmn1r255 uc012fcc.1 uc012fcc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fcc.1 uc012fcc.2 
ENSMUST00000173903.2 Cchcr1 ENSMUST00000173903.2 coiled-coil alpha-helical rod protein 1, transcript variant 1 (from RefSeq NM_001372297.1) Cchcr1 ENSMUST00000173903.1 G3UWS7 G3UWS7_MOUSE NM_001372297 uc289knz.1 uc289knz.2 May be a regulator of keratinocyte proliferation or differentiation. Cytoplasm Nucleus cell differentiation uc289knz.1 uc289knz.2 
ENSMUST00000173904.4 Or14c42-ps1 ENSMUST00000173904.4 Or14c42-ps1 (from geneSymbol) ENSMUST00000173904.1 ENSMUST00000173904.2 ENSMUST00000173904.3 uc291sjl.1 uc291sjl.2 uc291sjl.1 uc291sjl.2 
ENSMUST00000173932.8 Ndst4 ENSMUST00000173932.8 N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4 (from RefSeq NM_022565.3) D3Z1R7 ENSMUST00000173932.1 ENSMUST00000173932.2 ENSMUST00000173932.3 ENSMUST00000173932.4 ENSMUST00000173932.5 ENSMUST00000173932.6 ENSMUST00000173932.7 Hsst4 NDST4_MOUSE NM_022565 Q9EQW8 uc008rfw.1 uc008rfw.2 uc008rfw.3 uc008rfw.4 Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity. Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha- D-glucosaminyl-[heparan sulfate](n); Xref=Rhea:RHEA:21980, Rhea:RHEA- COMP:9830, Rhea:RHEA-COMP:14602, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:140572; EC=2.8.2.8; Glycan metabolism; heparan sulfate biosynthesis. Glycan metabolism; heparin biosynthesis. Monomer. Golgi apparatus membrane ; Single- pass type II membrane protein Expressed at low level in brain and throughout embryogenesis. Not expressed in other tissues. The presence of 4 different heparan sulfate N- deacetylase/N-sulfotransferase enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences. Belongs to the sulfotransferase 1 family. NDST subfamily. Golgi membrane catalytic activity Golgi apparatus sulfotransferase activity metabolic process heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [heparan sulfate]-glucosamine N-sulfotransferase activity membrane integral component of membrane transferase activity hydrolase activity deacetylase activity heparin biosynthetic process heparan sulfate N-acetylglucosaminyltransferase activity uc008rfw.1 uc008rfw.2 uc008rfw.3 uc008rfw.4 
ENSMUST00000173950.2 Gm18733 ENSMUST00000173950.2 Gm18733 (from geneSymbol) ENSMUST00000173950.1 uc289kna.1 uc289kna.2 uc289kna.1 uc289kna.2 
ENSMUST00000173969.2 Gon7 ENSMUST00000173969.2 GON7 subunit of KEOPS complex (from RefSeq NM_001142938.1) ENSMUST00000173969.1 GON7_MOUSE Gon7 NM_001142938 P0C8B4 uc011yqr.1 uc011yqr.2 uc011yqr.3 Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 plays a supporting role to the catalytic subunit OSGEP in the complex. Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes. Nucleus EKC/KEOPS complex nucleus uc011yqr.1 uc011yqr.2 uc011yqr.3 
ENSMUST00000173978.2 Gm45060 ENSMUST00000173978.2 Gm45060 (from geneSymbol) AK144076 ENSMUST00000173978.1 uc291exz.1 uc291exz.2 uc291exz.1 uc291exz.2 
ENSMUST00000173985.10 Grp ENSMUST00000173985.10 Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (PubMed:28280205, PubMed:17653196, PubMed:26658875). Contributes primarily to nonhistaminergic itch sensation (PubMed:28280205). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (PubMed:12526815). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (PubMed:34610277). Contributes to the regulation of food intake (PubMed:12176666). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Contributes to the induction of sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). (from UniProt Q8R1I2) AK133508 ENSMUST00000173985.1 ENSMUST00000173985.2 ENSMUST00000173985.3 ENSMUST00000173985.4 ENSMUST00000173985.5 ENSMUST00000173985.6 ENSMUST00000173985.7 ENSMUST00000173985.8 ENSMUST00000173985.9 GRP_MOUSE Q3UTL2 Q8R1I2 uc289pkl.1 uc289pkl.2 uc289pkl.3 Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (PubMed:28280205, PubMed:17653196, PubMed:26658875). Contributes primarily to nonhistaminergic itch sensation (PubMed:28280205). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (PubMed:12526815). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (PubMed:34610277). Contributes to the regulation of food intake (PubMed:12176666). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Contributes to the induction of sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). [Neuromedin-C]: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation. Secreted Cytoplasmic vesicle, secretory vesicle lumen Cell projection, neuron projection Note=In neurons of the retrotrapezoid nucleus/parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex. Detected in peptidergic dorsal root ganglion neurons (at protein level) (PubMed:17653196). Expressed in several dozen neurons throughout the dorsal retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG) as well as in scattered cells in the nucleus tractus solitarius and parabrachial nucleus (at protein level) (PubMed:26855425). Within the RTN/pFRG, expressed in neuronal subpopulations distinct from those expressing Nmb (at protein level) (PubMed:26855425). Expressed in L6 corticothalamic neurons (at protein level) (PubMed:34610277). Strongly expressed in several input areas of the auditory cortex including the lateral amygdala, contralateral auditory cortex, temporal association area, perirhinal cortex and auditory thalamic nuclei (at protein level) (PubMed:34610277). Detected in the suprachiasmatic nucleus in the hypothalamus (PubMed:28280205). Detected in a subset of glutamatergic cells in the cortex (PubMed:34610277). Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus (PubMed:12526815). Contrary to wild-type, mutant mice do not display imitative scratching after observing spontaneous scratching behavior in another mouse (PubMed:28280205). Belongs to the bombesin/neuromedin-B/ranatensin family. neuropeptide hormone activity extracellular region extracellular space neuropeptide signaling pathway cytoplasmic vesicle secretory granule lumen social behavior psychomotor behavior response to external biotic stimulus positive regulation of peptide hormone secretion positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway uc289pkl.1 uc289pkl.2 uc289pkl.3 
ENSMUST00000173993.4 Gm20406 ENSMUST00000173993.4 Gm20406 (from geneSymbol) ENSMUST00000173993.1 ENSMUST00000173993.2 ENSMUST00000173993.3 uc292dqx.1 uc292dqx.2 uc292dqx.3 uc292dqx.4 uc292dqx.1 uc292dqx.2 uc292dqx.3 uc292dqx.4 
ENSMUST00000173996.8 Vcf2 ENSMUST00000173996.8 VCP nuclear cofactor family member 2, transcript variant 5 (from RefSeq NM_001359039.1) A2ANF5 A2ANF5_MOUSE ENSMUST00000173996.1 ENSMUST00000173996.2 ENSMUST00000173996.3 ENSMUST00000173996.4 ENSMUST00000173996.5 ENSMUST00000173996.6 ENSMUST00000173996.7 NM_001359039 Tmem29 uc012hqm.1 uc012hqm.2 molecular_function biological_process methylated histone binding uc012hqm.1 uc012hqm.2 
ENSMUST00000174002.2 Gm20405 ENSMUST00000174002.2 Gm20405 (from geneSymbol) ENSMUST00000174002.1 uc288ykp.1 uc288ykp.2 uc288ykp.1 uc288ykp.2 
ENSMUST00000174014.3 Gm20444 ENSMUST00000174014.3 Gm20444 (from geneSymbol) ENSMUST00000174014.1 ENSMUST00000174014.2 uc292glu.1 uc292glu.2 uc292glu.1 uc292glu.2 
ENSMUST00000174019.2 Gm42936 ENSMUST00000174019.2 Gm42936 (from geneSymbol) BC094673 ENSMUST00000174019.1 uc290uws.1 uc290uws.2 uc290uws.1 uc290uws.2 
ENSMUST00000174025.3 Or2h2b-ps1 ENSMUST00000174025.3 Or2h2b-ps1 (from geneSymbol) ENSMUST00000174025.1 ENSMUST00000174025.2 uc289kyc.1 uc289kyc.2 uc289kyc.1 uc289kyc.2 
ENSMUST00000174032.3 Gm20404 ENSMUST00000174032.3 Gm20404 (from geneSymbol) ENSMUST00000174032.1 ENSMUST00000174032.2 uc291ibk.1 uc291ibk.2 uc291ibk.1 uc291ibk.2 
ENSMUST00000174064.9 Apoe ENSMUST00000174064.9 apolipoprotein E, transcript variant 1 (from RefSeq NM_009696.4) Apoe ENSMUST00000174064.1 ENSMUST00000174064.2 ENSMUST00000174064.3 ENSMUST00000174064.4 ENSMUST00000174064.5 ENSMUST00000174064.6 ENSMUST00000174064.7 ENSMUST00000174064.8 NM_009696 Q3TXU4 Q3TXU4_MOUSE uc009fmy.1 uc009fmy.2 uc009fmy.3 uc009fmy.4 uc009fmy.5 This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015]. Endosome, multivesicular body Extracellular vesicle Secreted, extracellular space Vesicle Belongs to the apolipoprotein A1/A4/E family. beta-amyloid binding negative regulation of endothelial cell proliferation receptor binding lipid transporter activity phospholipid binding extracellular region extracellular space endoplasmic reticulum Golgi apparatus plasma membrane triglyceride metabolic process lipid transport receptor-mediated endocytosis G-protein coupled receptor signaling pathway nitric oxide mediated signal transduction long-term memory heparin binding cholesterol metabolic process lipid binding negative regulation of platelet activation negative regulation of endothelial cell migration positive regulation of cholesterol esterification positive regulation of cholesterol efflux positive regulation of neuron projection development negative regulation of neuron projection development long-chain fatty acid transport antioxidant activity protein import virion assembly cGMP-mediated signaling negative regulation of blood coagulation extracellular matrix neuron projection development negative regulation of cellular protein metabolic process regulation of Cdc42 protein signal transduction positive regulation of low-density lipoprotein particle receptor catabolic process cholesterol efflux phospholipid efflux very-low-density lipoprotein particle low-density lipoprotein particle intermediate-density lipoprotein particle high-density lipoprotein particle very-low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling high-density lipoprotein particle assembly chylomicron remnant clearance high-density lipoprotein particle clearance very-low-density lipoprotein particle clearance locomotory exploration behavior lipoprotein metabolic process lipoprotein biosynthetic process chylomicron cholesterol homeostasis identical protein binding protein homodimerization activity amyloid precursor protein metabolic process synaptic cleft regulation of protein complex assembly heparan sulfate proteoglycan binding negative regulation of MAP kinase activity negative regulation of blood vessel endothelial cell migration reverse cholesterol transport positive regulation by host of viral process macromolecular complex binding negative regulation of cholesterol biosynthetic process positive regulation of endocytosis positive regulation of transcription, DNA-templated positive regulation of lipid biosynthetic process metal chelating activity protein dimerization activity tau protein binding negative regulation of protein secretion low-density lipoprotein particle receptor binding positive regulation of nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis regulation of protein metabolic process fatty acid homeostasis phosphatidylcholine-sterol O-acyltransferase activator activity positive regulation of dendritic spine development regulation of proteasomal protein catabolic process response to caloric restriction very-low-density lipoprotein particle receptor binding positive regulation of ERK1 and ERK2 cascade triglyceride-rich lipoprotein particle clearance intermediate-density lipoprotein particle clearance negative regulation of canonical Wnt signaling pathway regulation of cholesterol metabolic process AMPA glutamate receptor clustering NMDA glutamate receptor clustering cellular oxidant detoxification glutamatergic synapse regulation of beta-amyloid clearance negative regulation of long-term synaptic potentiation negative regulation of neuron death positive regulation of postsynaptic membrane organization negative regulation of presynaptic membrane organization negative regulation of beta-amyloid formation positive regulation of dendritic spine maintenance regulation of amyloid precursor protein catabolic process positive regulation of phospholipid efflux positive regulation of lipid transport across blood brain barrier lipoprotein particle regulation of behavioral fear response uc009fmy.1 uc009fmy.2 uc009fmy.3 uc009fmy.4 uc009fmy.5 
ENSMUST00000174066.3 Gm20532 ENSMUST00000174066.3 Gm20532 (from geneSymbol) BC051954 ENSMUST00000174066.1 ENSMUST00000174066.2 G3UXR8 G3UXR8_MOUSE Gm20532 uc289uff.1 uc289uff.2 uc289uff.3 uc289uff.1 uc289uff.2 uc289uff.3 
ENSMUST00000174078.2 Iffo2 ENSMUST00000174078.2 intermediate filament family orphan 2, transcript variant 3 (from RefSeq NM_001425010.1) ENSMUST00000174078.1 IFFO2_MOUSE NM_001425010 Q8R2V2 uc008vmo.1 uc008vmo.2 uc008vmo.3 uc008vmo.4 Belongs to the intermediate filament family. Sequence=AAH27170.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH27170.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; molecular_function cellular_component intermediate filament biological_process uc008vmo.1 uc008vmo.2 uc008vmo.3 uc008vmo.4 
ENSMUST00000174079.3 Gm20511 ENSMUST00000174079.3 Gm20511 (from geneSymbol) ENSMUST00000174079.1 ENSMUST00000174079.2 uc288ctj.1 uc288ctj.2 uc288ctj.3 uc288ctj.1 uc288ctj.2 uc288ctj.3 
ENSMUST00000174082.2 1700039E22Rik ENSMUST00000174082.2 RIKEN cDNA 1700039E22 gene (from RefSeq NR_045315.1) ENSMUST00000174082.1 NR_045315 uc029tsl.1 uc029tsl.2 uc029tsl.1 uc029tsl.2 
ENSMUST00000174088.3 Actl9 ENSMUST00000174088.3 actin-like 9 (from RefSeq NM_183282.2) ACTL9_MOUSE Actl7c ENSMUST00000174088.1 ENSMUST00000174088.2 NM_183282 Q497R1 Q5EBK5 Q8CG27 uc008byl.1 uc008byl.2 uc008byl.3 uc008byl.4 Testis-specic protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation. Interacts with ACTL7A. Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasm, cytoskeleton, perinuclear theca Note=Localizes predominantly in the equatorial segment of the sperm head and neck regions, with some localization in the acrosomal segment of the head. Colocalizes in the acrosomal and equatorial segments of sperm with ACTL7A. Colocalizes with PLCZ1 in the equatorial segment of the head of capacitated sperm. Belongs to the actin family. molecular_function cytoplasm cytoskeleton biological_process actin cytoskeleton uc008byl.1 uc008byl.2 uc008byl.3 uc008byl.4 
ENSMUST00000174100.2 Gm20455 ENSMUST00000174100.2 Gm20455 (from geneSymbol) AK144533 ENSMUST00000174100.1 uc292oqc.1 uc292oqc.2 uc292oqc.1 uc292oqc.2 
ENSMUST00000174113.8 Gm49325 ENSMUST00000174113.8 Gm49325 (from geneSymbol) AK012742 ENSMUST00000174113.1 ENSMUST00000174113.2 ENSMUST00000174113.3 ENSMUST00000174113.4 ENSMUST00000174113.5 ENSMUST00000174113.6 ENSMUST00000174113.7 G3UZ60 G3UZ60_MOUSE Gm49325 uc287slu.1 uc287slu.2 uc287slu.1 uc287slu.2 
ENSMUST00000174143.2 Nat8f6 ENSMUST00000174143.2 Has histone acetyltransferase activity in vitro, with specificity for histone H4. (from UniProt Q9JIY8) AF163316 Cml3 ENSMUST00000174143.1 NT8F3_MOUSE Nat8f3 Q8BQW2 Q91WM7 Q9JIY8 uc033isy.1 uc033isy.2 uc033isy.3 Has histone acetyltransferase activity in vitro, with specificity for histone H4. Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; Nucleus membrane ; Multi-pass membrane protein Cytoplasm, perinuclear region Cytoplasm Note=C-terminally tagged constructs localize to the nuclear membrane and perinuclear region. N-terminally tagged constructs show a punctate cytoplasmic distribution. Belongs to the camello family. gastrulation with mouth forming second axis elongation histone acetyltransferase activity nucleus cytoplasm endoplasmic reticulum Golgi apparatus negative regulation of cell adhesion N-acetyltransferase activity H4 histone acetyltransferase activity membrane integral component of membrane histone acetylation transferase activity transferase activity, transferring acyl groups nuclear membrane histone H4 acetylation perinuclear region of cytoplasm extracellular space uc033isy.1 uc033isy.2 uc033isy.3 
ENSMUST00000174158.3 Or13g1 ENSMUST00000174158.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TS01) ENSMUST00000174158.1 ENSMUST00000174158.2 Olfr309 Or13g1 Q7TS01 Q7TS01_MOUSE uc291siq.1 uc291siq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291siq.1 uc291siq.2 
ENSMUST00000174177.2 Cdk3 ENSMUST00000174177.2 cyclin dependent kinase 3 (from RefSeq NR_004853.1) ENSMUST00000174177.1 NR_004853 uc288drr.1 uc288drr.2 uc288drr.1 uc288drr.2 
ENSMUST00000174190.2 Mpig6b ENSMUST00000174190.2 megakaryocyte and platelet inhibitory receptor G6b, transcript variant 1 (from RefSeq NM_001191012.1) AU023871 D7PDD4 ENSMUST00000174190.1 G6B_MOUSE G6b G6b-B Mpig6b NM_001191012 uc012aqy.1 uc012aqy.2 uc012aqy.3 Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:23112346). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (By similarity). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:23112346). Appears to operate in a calcium-independent manner (By similarity). Interacts (via ITIM motif) with PTPN6 and PTPN11 (PubMed:23112346). Binds to heparin (By similarity). Cell membrane ; Single-pass type I membrane protein Expressed in mature megakaryocytes and platelets. Not expressed by immature megakaryocytes. Contains both a transmembrane region and 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine- based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. The 2 ITIM motifs of isoform B are required for the inhibition of CLEC1B and GP6:FCER1G signaling and platelet activation. N-glycosylated. May be O-glycosylated. Phosphorylated. Mutant mice exhibit macrothrombocytopenia (reduced platelet numbers and the presence of enlarged platelets) and a susceptibility to bleeding because of defective platelet production and function. They show an increased platelet turnover leading to reduced platelet numbers. Their megakaryocytes exhibit reduced integrin- mediated functions, defective formation of proplatelets as well as an increased metalloproteinase production. protein binding Golgi apparatus plasma membrane integrin-mediated signaling pathway blood coagulation negative regulation of signal transduction membrane integral component of membrane erythrocyte differentiation megakaryocyte differentiation platelet formation megakaryocyte development uc012aqy.1 uc012aqy.2 uc012aqy.3 
ENSMUST00000174203.4 Gm20509 ENSMUST00000174203.4 Nucleus (from UniProt G3UZF1) 2410004A20Rik AK145595 ENSMUST00000174203.1 ENSMUST00000174203.2 ENSMUST00000174203.3 G3UZF1 G3UZF1_MOUSE Gm20509 uc292isy.1 uc292isy.2 uc292isy.3 Nucleus Belongs to the KHDC1 family. Belongs to the eukaryotic ribosomal protein eL24 family. ribosomal large subunit assembly RNA binding structural constituent of ribosome translation cytosolic large ribosomal subunit assembly of large subunit precursor of preribosome uc292isy.1 uc292isy.2 uc292isy.3 
ENSMUST00000174252.8 Scyl2 ENSMUST00000174252.8 SCY1-like 2 (S. cerevisiae), transcript variant 1 (from RefSeq NM_198021.3) Cvak104 D10Ertd802e ENSMUST00000174252.1 ENSMUST00000174252.2 ENSMUST00000174252.3 ENSMUST00000174252.4 ENSMUST00000174252.5 ENSMUST00000174252.6 ENSMUST00000174252.7 NM_198021 Q3UT57 Q3UWU9 Q8CFE4 Q8K0M4 SCYL2_MOUSE Scyl2 uc007gsm.1 uc007gsm.2 uc007gsm.3 Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system. A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (By similarity). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (PubMed:26203146). Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex. Cytoplasmic vesicle, clathrin-coated vesicle Golgi apparatus, trans-Golgi network membrane Endosome membrane Note=Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CFE4-1; Sequence=Displayed; Name=2; IsoId=Q8CFE4-2; Sequence=VSP_020980, VSP_020981, VSP_020982; Ubiquitously expressed. Could autophosphorylate in presence of poly-L-lysine. Disruption of the gene results in perinatal lethality due to impaired neuronal functions. Mutant animals that survive to adulthood show growth retardation and severe sensorimotor deficits. The neurologic deficits in these mice is associated with the degeneration of several neuronal populations, most notably CA3 pyramidal neurons of the hippocampus, resulting from excitotoxicity. This is associated with excessive expression and activation of calcium- permeable glutamate receptors at the synapse. A wide variety of clathrin-mediated functions and lysosomal pathways are however preserved in mutant mice. Belongs to the protein kinase superfamily. positive regulation of receptor internalization protein kinase activity receptor binding protein binding ATP binding cytoplasm endosome Golgi apparatus protein phosphorylation endosome to lysosome transport endosome membrane membrane clathrin-coated vesicle cytoplasmic vesicle perinuclear region of cytoplasm negative regulation of canonical Wnt signaling pathway receptor internalization involved in canonical Wnt signaling pathway positive regulation of clathrin-dependent endocytosis uc007gsm.1 uc007gsm.2 uc007gsm.3 
ENSMUST00000174259.8 Psme1 ENSMUST00000174259.8 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) (from RefSeq NM_011189.1) ENSMUST00000174259.1 ENSMUST00000174259.2 ENSMUST00000174259.3 ENSMUST00000174259.4 ENSMUST00000174259.5 ENSMUST00000174259.6 ENSMUST00000174259.7 NM_011189 Psme1 Q5HZK3 Q5HZK3_MOUSE uc007tzd.1 uc007tzd.2 uc007tzd.3 Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers. Belongs to the PA28 family. proteasome complex proteasome activator complex uc007tzd.1 uc007tzd.2 uc007tzd.3 
ENSMUST00000174262.4 Or14n1-ps1 ENSMUST00000174262.4 Or14n1-ps1 (from geneSymbol) ENSMUST00000174262.1 ENSMUST00000174262.2 ENSMUST00000174262.3 uc291sje.1 uc291sje.2 uc291sje.1 uc291sje.2 
ENSMUST00000174277.2 A730060N03Rik ENSMUST00000174277.2 A730060N03Rik (from geneSymbol) AK043153 ENSMUST00000174277.1 uc007woq.1 uc007woq.2 uc007woq.1 uc007woq.2 
ENSMUST00000174278.9 Dctd ENSMUST00000174278.9 dCMP deaminase, transcript variant 3 (from RefSeq NM_001161516.2) DCTD_MOUSE Dctd ENSMUST00000174278.1 ENSMUST00000174278.2 ENSMUST00000174278.3 ENSMUST00000174278.4 ENSMUST00000174278.5 ENSMUST00000174278.6 ENSMUST00000174278.7 ENSMUST00000174278.8 NM_001161516 Q8BP55 Q8K2D6 uc012gdr.1 uc012gdr.2 uc012gdr.3 uc012gdr.4 Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS. Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP). Reaction=dCMP + H(+) + H2O = dUMP + NH4(+); Xref=Rhea:RHEA:22924, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57566, ChEBI:CHEBI:246422; EC=3.5.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22925; Evidence=; Reaction=5-hydroxymethyl-dCMP + H(+) + H2O = 5-hydroxymethyl-dUMP + NH4(+); Xref=Rhea:RHEA:77175, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57962, ChEBI:CHEBI:90409; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77176; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP. Homohexamer. Belongs to the cytidine and deoxycytidylate deaminase family. catalytic activity dCMP deaminase activity cytoplasm pyrimidine nucleotide metabolic process dUMP biosynthetic process dTMP biosynthetic process metabolic process zinc ion binding nucleotide biosynthetic process hydrolase activity identical protein binding metal ion binding uc012gdr.1 uc012gdr.2 uc012gdr.3 uc012gdr.4 
ENSMUST00000174283.2 Gm19301 ENSMUST00000174283.2 Gm19301 (from geneSymbol) AK146748 ENSMUST00000174283.1 uc007usf.1 uc007usf.2 uc007usf.1 uc007usf.2 
ENSMUST00000174285.8 Plut ENSMUST00000174285.8 PDX1 associated lncRNA, upregulator of transcription (from RefSeq NR_038157.1) ENSMUST00000174285.1 ENSMUST00000174285.2 ENSMUST00000174285.3 ENSMUST00000174285.4 ENSMUST00000174285.5 ENSMUST00000174285.6 ENSMUST00000174285.7 NR_038157 uc009anx.1 uc009anx.2 uc009anx.3 uc009anx.1 uc009anx.2 uc009anx.3 
ENSMUST00000174299.9 Rxrb ENSMUST00000174299.9 retinoid X receptor beta, transcript variant 2 (from RefSeq NM_011306.4) ENSMUST00000174299.1 ENSMUST00000174299.2 ENSMUST00000174299.3 ENSMUST00000174299.4 ENSMUST00000174299.5 ENSMUST00000174299.6 ENSMUST00000174299.7 ENSMUST00000174299.8 NM_011306 Nr2b2 P28704 P33243 RXRB_MOUSE uc289kap.1 uc289kap.2 uc289kap.3 Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE). Homodimer (in vitro). Heterodimer with other retinoic acid receptor family members. Binds DNA preferentially as a RAR/RXR heterodimer. Interacts with NR1H3 (By similarity). Interacts with AKAP13 (PubMed:20139090). Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=Long; IsoId=P28704-1; Sequence=Displayed; Name=Short; IsoId=P28704-2; Sequence=VSP_003678; In all tissues tested, including brain, thymus, spleen and liver. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Belongs to the nuclear hormone receptor family. NR2 subfamily. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development maternal placenta development DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter zinc ion binding cell differentiation thyroid hormone receptor coactivator activity regulation of myelination response to retinoic acid protein homodimerization activity vitamin D receptor binding retinoic acid receptor binding steroid hormone mediated signaling pathway sequence-specific DNA binding transcription regulatory region DNA binding retinoic acid-responsive element binding positive regulation of transcription from RNA polymerase II promoter metal ion binding thyroid hormone receptor binding protein heterodimerization activity retinoic acid receptor signaling pathway anatomical structure development ventricular cardiac muscle cell differentiation cardiac muscle cell proliferation cellular response to retinoic acid RNA polymerase II transcription factor complex uc289kap.1 uc289kap.2 uc289kap.3 
ENSMUST00000174302.8 Ubtf ENSMUST00000174302.8 upstream binding transcription factor, RNA polymerase I, transcript variant 1 (from RefSeq NM_011551.8) A2AWT5 A2AWT5_MOUSE ENSMUST00000174302.1 ENSMUST00000174302.2 ENSMUST00000174302.3 ENSMUST00000174302.4 ENSMUST00000174302.5 ENSMUST00000174302.6 ENSMUST00000174302.7 NM_011551 Ubtf uc007lrl.1 uc007lrl.2 uc007lrl.3 uc007lrl.4 RNA polymerase I CORE element sequence-specific DNA binding RNA polymerase I upstream control element sequence-specific DNA binding RNA polymerase I transcriptional preinitiation complex assembly fibrillar center DNA binding chromatin binding nucleus nucleolus transcription from RNA polymerase I promoter scaffold protein binding uc007lrl.1 uc007lrl.2 uc007lrl.3 uc007lrl.4 
ENSMUST00000174320.2 Gm6309 ENSMUST00000174320.2 predicted gene 6309 (from RefSeq NM_001378677.1) ENSMUST00000174320.1 Gm6309 L7N481 L7N481_MOUSE NM_001378677 uc291btg.1 uc291btg.2 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc291btg.1 uc291btg.2 
ENSMUST00000174362.3 Or14c44 ENSMUST00000174362.3 olfactory receptor family 14 subfamily C member 44 (from RefSeq NM_212436.2) ENSMUST00000174362.1 ENSMUST00000174362.2 NM_212436 Olfr301 Or14c44 Q7TS04 Q7TS04_MOUSE uc009iez.1 uc009iez.2 uc009iez.3 uc009iez.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB173709.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: experimental evidence (PMID:11802173) RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Odorant receptor. Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009iez.1 uc009iez.2 uc009iez.3 uc009iez.4 
ENSMUST00000174364.2 Vmn1r246 ENSMUST00000174364.2 vomeronasal 1 receptor 246 (from RefSeq NM_001167163.1) ENSMUST00000174364.1 Gm4141 Gm4201 K9J7H2 K9J7H2_MOUSE NM_001167163 Vmn1r246 Vmn1r256 uc012fcd.1 uc012fcd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fcd.1 uc012fcd.2 
ENSMUST00000174370.8 Cfap221 ENSMUST00000174370.8 cilia and flagella associated protein 221 (from RefSeq NM_001115074.2) A9Q751 Cfap221 ENSMUST00000174370.1 ENSMUST00000174370.2 ENSMUST00000174370.3 ENSMUST00000174370.4 ENSMUST00000174370.5 ENSMUST00000174370.6 ENSMUST00000174370.7 Gm101 NM_001115074 PCDP1_MOUSE Pcdp1 uc287let.1 uc287let.2 May play a role in cilium morphogenesis. Interacts with calmodulin; calcium-dependent. Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm toplasm, cytoskeleton Note=Localizes to the manchette in elongating spermatids in a SPAG17-dependent manner. Expressed in testis, specifically in developing spermatocytes and spermatids but not in immature spermatogonia. Expressed in the ciliated respiratory epithelial cells lining the sinuses, trachea and bronchi (at protein level). Expression in testis starts at P20. Mice lacking Pcdp1 have several phenotypes associated with primary ciliary diskinesia, including hydrocephalus, male infertility and respiratory abnormalities. Hydrocephalus is observed on the B6 background but not on the 129 background. Male infertility is observed on both backgrounds and is due to an absence of mature spermatozoa in the seminiferous tubules. Belongs to the PCDP1 family. cilium movement calmodulin binding cytoplasm cytoskeleton cilium axoneme cell projection organization cell projection motile cilium assembly cilium assembly uc287let.1 uc287let.2 
ENSMUST00000174382.8 H2-T10 ENSMUST00000174382.8 H2-T10 (from geneSymbol) AK161731 ENSMUST00000174382.1 ENSMUST00000174382.2 ENSMUST00000174382.3 ENSMUST00000174382.4 ENSMUST00000174382.5 ENSMUST00000174382.6 ENSMUST00000174382.7 uc289kth.1 uc289kth.2 uc289kth.1 uc289kth.2 
ENSMUST00000174388.4 Vmn2r39 ENSMUST00000174388.4 vomeronasal 2, receptor 39, transcript variant 2 (from RefSeq NM_001385077.1) ENSMUST00000174388.1 ENSMUST00000174388.2 ENSMUST00000174388.3 L7N2E5 L7N2E5_MOUSE NM_001385077 Vmn2r39 uc012eyd.1 uc012eyd.2 uc012eyd.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012eyd.1 uc012eyd.2 uc012eyd.3 
ENSMUST00000174404.8 Klrb1c ENSMUST00000174404.8 killer cell lectin-like receptor subfamily B member 1C, transcript variant 1 (from RefSeq NM_001159904.2) ENSMUST00000174404.1 ENSMUST00000174404.2 ENSMUST00000174404.3 ENSMUST00000174404.4 ENSMUST00000174404.5 ENSMUST00000174404.6 ENSMUST00000174404.7 KLRBC_MOUSE Ly55c NM_001159904 Nkrp1c P27814 Q541U5 Q925G3 uc009eep.1 uc009eep.2 uc009eep.3 uc009eep.4 Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production. Homodimer; disulfide-linked. Interacts with tyrosine kinase LCK. Membrane; Single-pass type II membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27814-1; Sequence=Displayed; Name=2; IsoId=P27814-2; Sequence=VSP_022317; Expressed in natural killer cells. The anti-NK1.1 monoclonal antibody (PK136), recognizing Klrb1b and Klrb1c genes, is known to identify NK cells from B6 and SLJ mice, but not from BALB/c ones. A single mutation Thr-191 present in Klrb1b and Klrb1c genes of BALB/c mice may be responsible for lack of NK1.1 reactivity in these mice. Indeed, when Lys-217 of BALB/c mice Klrb1c is mutated to Glu-217 present in B6 and SLJ mice, it does not confer NK1.1 reactivity. plasma membrane integral component of plasma membrane external side of plasma membrane cell surface membrane integral component of membrane natural killer cell activation carbohydrate binding signaling receptor activity protein homodimerization activity positive regulation of natural killer cell mediated cytotoxicity uc009eep.1 uc009eep.2 uc009eep.3 uc009eep.4 
ENSMUST00000174407.3 Zfp141 ENSMUST00000174407.3 zinc finger protein 141, transcript variant 8 (from RefSeq NM_001421555.1) ENSMUST00000174407.1 ENSMUST00000174407.2 G3UY09 G3UY09_MOUSE NM_001421555 Zfp141 uc009gmb.1 uc009gmb.2 uc009gmb.3 uc009gmb.4 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc009gmb.1 uc009gmb.2 uc009gmb.3 uc009gmb.4 
ENSMUST00000174409.2 Garin5b ENSMUST00000174409.2 golgi associated RAB2 interactor family member 5B (from RefSeq NM_172895.3) ENSMUST00000174409.1 Garin5b L7N480 L7N480_MOUSE NM_172895 uc012ewx.1 uc012ewx.2 uc012ewx.3 uc012ewx.4 Belongs to the GARIN family. molecular_function biological_process uc012ewx.1 uc012ewx.2 uc012ewx.3 uc012ewx.4 
ENSMUST00000174433.2 Vmn2r47 ENSMUST00000174433.2 vomeronasal 2, receptor 47 (from RefSeq NM_001105151.1) ENSMUST00000174433.1 K7N709 K7N709_MOUSE NM_001105151 Vmn2r47 uc291lhe.1 uc291lhe.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc291lhe.1 uc291lhe.2 
ENSMUST00000174451.2 Vmn1r258 ENSMUST00000174451.2 vomeronasal 1 receptor 258 (from RefSeq NM_001167164.1) D3YTW8 D3YTW8_MOUSE D3YTX7 D3YTX8 E9Q2L6 E9Q8L4 E9Q8L5 ENSMUST00000174451.1 G3UYH3 Gm4175 Gm4214 NM_001167164 Vmn1r247 Vmn1r258 uc012fem.1 uc012fem.2 uc012fem.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fem.1 uc012fem.2 uc012fem.3 
ENSMUST00000174459.2 Gypc ENSMUST00000174459.2 glycophorin C, transcript variant 1 (from RefSeq NM_001048207.1) ENSMUST00000174459.1 GLPC_MOUSE NM_001048207 Q6XFR5 Q78HU7 uc008ejk.1 uc008ejk.2 uc008ejk.3 Cell membrane ; Single-pass type III membrane protein Note=Linked to the membrane via band 4.1. Belongs to the glycophorin-C family. plasma membrane membrane integral component of membrane cortical cytoskeleton uc008ejk.1 uc008ejk.2 uc008ejk.3 
ENSMUST00000174462.8 Zfp266 ENSMUST00000174462.8 zinc finger protein 266, transcript variant 2 (from RefSeq NM_001135019.1) E9Q2S7 E9Q2S7_MOUSE ENSMUST00000174462.1 ENSMUST00000174462.2 ENSMUST00000174462.3 ENSMUST00000174462.4 ENSMUST00000174462.5 ENSMUST00000174462.6 ENSMUST00000174462.7 NM_001135019 Zfp266 uc009oiv.1 uc009oiv.2 uc009oiv.3 uc009oiv.4 uc009oiv.5 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc009oiv.1 uc009oiv.2 uc009oiv.3 uc009oiv.4 uc009oiv.5 
ENSMUST00000174490.9 Pax2 ENSMUST00000174490.9 paired box 2, transcript variant 7 (from RefSeq NM_011037.5) A0A0R4J267 A0A0R4J267_MOUSE ENSMUST00000174490.1 ENSMUST00000174490.2 ENSMUST00000174490.3 ENSMUST00000174490.4 ENSMUST00000174490.5 ENSMUST00000174490.6 ENSMUST00000174490.7 ENSMUST00000174490.8 NM_011037 Pax2 uc008hqa.1 uc008hqa.2 uc008hqa.3 uc008hqa.4 uc008hqa.5 Nucleus core promoter proximal region sequence-specific DNA binding branching involved in ureteric bud morphogenesis DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleolus lysosome Golgi apparatus microtubule organizing center regulation of transcription, DNA-templated multicellular organism development aging transcription factor binding positive regulation of cell proliferation response to nutrient levels centriolar satellite regulation of metanephros size negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of cytolysis positive regulation of transcription from RNA polymerase II promoter positive regulation of epithelial cell proliferation cellular response to epidermal growth factor stimulus metanephric epithelium development negative regulation of reactive oxygen species metabolic process uc008hqa.1 uc008hqa.2 uc008hqa.3 uc008hqa.4 uc008hqa.5 
ENSMUST00000174499.8 Brsk2 ENSMUST00000174499.8 Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr- 175 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-261 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. (from UniProt Q69Z98) AK173268 BRSK2_MOUSE ENSMUST00000174499.1 ENSMUST00000174499.2 ENSMUST00000174499.3 ENSMUST00000174499.4 ENSMUST00000174499.5 ENSMUST00000174499.6 ENSMUST00000174499.7 Kiaa4256 Q699J3 Q699J4 Q69Z98 Q6DMN7 Q6PHM0 Sada uc009kmi.1 uc009kmi.2 uc009kmi.3 Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr- 175 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-261 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl- [tau protein]; Xref=Rhea:RHEA:12801, Rhea:RHEA-COMP:13701, Rhea:RHEA- COMP:13702, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.26; Evidence=; Reaction=ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L- threonyl-[tau protein]; Xref=Rhea:RHEA:53904, Rhea:RHEA-COMP:13703, Rhea:RHEA-COMP:13704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.26; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation on Thr-175 by STK11/LKB1. Interacts with FZR1, a regulatory subunit of the APC ubiquitin ligase complex. Interacts with COPS5. Interacts with PAK1 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, perinuclear region Endoplasmic reticulum Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q69Z98-1; Sequence=Displayed; Name=2; Synonyms=SADA-beta; IsoId=Q69Z98-2; Sequence=VSP_022605; Name=3; Synonyms=SADA-gamma; IsoId=Q69Z98-3; Sequence=VSP_022606; Name=4; Synonyms=SADA-alpha; IsoId=Q69Z98-4; Sequence=VSP_022607, VSP_022608; Detected in pancreas islets and in brain (at protein level). Detected in brain and pancreas. The KEN box motif is required for interaction with FZR1/CDH1 and essential for APC(CDH1)-mediated ubiquitination. May be phosphorylated at Thr-261 by PKA (By similarity). Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-175 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-175 by PP2C. Polyubiquitinated by the APC complex in conjunction with FZR1, leading to its proteasomal degradation. Targeted for proteasomal degradation by interaction with COPS5. BRSK2 levels change during the cell cycle. BRSK2 levels are low at the G1/S boundary and gradually increase as cells progress into G2 phase. BRSK2 levels decrease rapidly at the end of mitosis (By similarity). No visible phenotype. Mice are fertile and healthy. In contrast, mice lacking both Brsk1 and Brsk2 show little spontaneous movement and are only weakly responsive to tactile stimulation: they die within 2 hours of birth. Defects are due to impaired neuronal differentiation and polarity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. G2/M transition of mitotic cell cycle nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm endoplasmic reticulum centrosome microtubule organizing center cytoskeleton protein phosphorylation exocytosis apoptotic process cell cycle nervous system development axonogenesis regulation of neuron projection development kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation protein kinase binding establishment of cell polarity neuron differentiation actin cytoskeleton reorganization intracellular signal transduction ERAD pathway metal ion binding perinuclear region of cytoplasm neuron projection morphogenesis tau-protein kinase activity regulation of axonogenesis ATPase binding cell division regulation of insulin secretion involved in cellular response to glucose stimulus intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress microtubule cytoskeleton organization involved in establishment of planar polarity uc009kmi.1 uc009kmi.2 uc009kmi.3 
ENSMUST00000174502.3 1700010K23Rik ENSMUST00000174502.3 RIKEN cDNA 1700010K23 gene (from RefSeq NR_040512.1) ENSMUST00000174502.1 ENSMUST00000174502.2 NR_040512 uc007zqm.1 uc007zqm.2 uc007zqm.3 uc007zqm.4 uc007zqm.1 uc007zqm.2 uc007zqm.3 uc007zqm.4 
ENSMUST00000174510.8 Ube2g2 ENSMUST00000174510.8 ubiquitin-conjugating enzyme E2G 2 (from RefSeq NM_019803.3) ENSMUST00000174510.1 ENSMUST00000174510.2 ENSMUST00000174510.3 ENSMUST00000174510.4 ENSMUST00000174510.5 ENSMUST00000174510.6 ENSMUST00000174510.7 NM_019803 Q3U431 Q3U431_MOUSE Ube2g2 uc007fwa.1 uc007fwa.2 uc007fwa.3 Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence=; Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding ubiquitin-protein transferase activity ATP binding transferase activity protein N-linked glycosylation via asparagine ER-associated ubiquitin-dependent protein catabolic process cellular response to interferon-beta cellular protein catabolic process ubiquitin conjugating enzyme activity protein K48-linked ubiquitination negative regulation of retrograde protein transport, ER to cytosol uc007fwa.1 uc007fwa.2 uc007fwa.3 
ENSMUST00000174525.8 H2-Q10 ENSMUST00000174525.8 Involved in the presentation of foreign antigens to the immune system. (from UniProt P01898) BC042572 ENSMUST00000174525.1 ENSMUST00000174525.2 ENSMUST00000174525.3 ENSMUST00000174525.4 ENSMUST00000174525.5 ENSMUST00000174525.6 ENSMUST00000174525.7 HA10_MOUSE O19475 P01898 Q31214 Q95HC3 uc289knn.1 uc289knn.2 Involved in the presentation of foreign antigens to the immune system. Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Membrane; Single-pass type I membrane protein. Belongs to the MHC class I family. Sequence=AAA39574.1; Type=Erroneous initiation; Evidence=; Sequence=AAA39676.1; Type=Erroneous initiation; Evidence=; positive regulation of T cell mediated cytotoxicity immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response external side of plasma membrane cell surface membrane integral component of membrane phagocytic vesicle membrane beta-2-microglobulin binding peptide binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex TAP binding protein heterodimerization activity endoplasmic reticulum exit site integral component of lumenal side of endoplasmic reticulum membrane uc289knn.1 uc289knn.2 
ENSMUST00000174538.2 Vmn1r112 ENSMUST00000174538.2 vomeronasal 1 receptor 112 (from RefSeq NM_001166847.1) ENSMUST00000174538.1 G3UY48 G3UY48_MOUSE NM_001166847 Vmn1r112 uc012fcm.1 uc012fcm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fcm.1 uc012fcm.2 
ENSMUST00000174545.9 Xpo4 ENSMUST00000174545.9 exportin 4, transcript variant 1 (from RefSeq NM_020506.2) A0A0R4J254 A0A0R4J254_MOUSE ENSMUST00000174545.1 ENSMUST00000174545.2 ENSMUST00000174545.3 ENSMUST00000174545.4 ENSMUST00000174545.5 ENSMUST00000174545.6 ENSMUST00000174545.7 ENSMUST00000174545.8 NM_020506 Xpo4 uc007udf.1 uc007udf.2 uc007udf.3 Nucleus Belongs to the exportin family. nuclear export signal receptor activity nucleoplasm cytosol positive regulation of protein export from nucleus nuclear export uc007udf.1 uc007udf.2 uc007udf.3 
ENSMUST00000174548.8 Hnrnpl ENSMUST00000174548.8 heterogeneous nuclear ribonucleoprotein L, transcript variant 9 (from RefSeq NR_175321.1) ENSMUST00000174548.1 ENSMUST00000174548.2 ENSMUST00000174548.3 ENSMUST00000174548.4 ENSMUST00000174548.5 ENSMUST00000174548.6 ENSMUST00000174548.7 HNRPL_MOUSE Hnrpl NR_175321 O54789 Q499X2 Q8K0S7 Q8R081 uc291nlz.1 uc291nlz.2 Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion (PubMed:22523384). Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3- coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with HNRNPLL. Interacts with APEX1; the interaction is DNA-dependent. Component of a complex with SETD2 (By similarity). Interacts with ELAVL1 (By similarity). Part of a transcription inhibitory ribonucleoprotein complex composed at least of the circular RNA circZNF827, ZNF827 and HNRNPK (By similarity). Interacts with CHD8 in an RNA-dependent manner. Nucleus, nucleoplasm Cytoplasm Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules. Detected in hematopoietic cells, including lymphoid progenitor cells. RRM domain 2 has moderate RNA-binding affinity. RRM domains 3 and 4 may facilitate RNA looping when binding to two appropriately separated binding sites within the same target pre-mRNA. Phosphorylation at Ser-541 by CaMK4 enhances interaction with a CaMK4-responsive RNA element (CaRRE1), and prevents inclusion of the stress axis-regulated exon (STREX) of the KCNMA1 potassium channel transcripts upon membrane depolarization. Complete lethality during early embryonic development. Sequence=AAH27206.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA 3'-UTR binding protein binding nucleus nucleoplasm cytoplasm cytosol mRNA processing cellular response to amino acid starvation ribonucleoprotein granule transcription regulatory region DNA binding pronucleus positive regulation of translation negative regulation of mRNA splicing, via spliceosome perinuclear region of cytoplasm pre-mRNA intronic binding positive regulation of mRNA binding mRNA CDS binding ribonucleoprotein complex uc291nlz.1 uc291nlz.2 
ENSMUST00000174552.8 Dip2c ENSMUST00000174552.8 disco interacting protein 2 homolog C (from RefSeq NM_001081426.2) B2RQ71 B2RQ71_MOUSE Dip2c ENSMUST00000174552.1 ENSMUST00000174552.2 ENSMUST00000174552.3 ENSMUST00000174552.4 ENSMUST00000174552.5 ENSMUST00000174552.6 ENSMUST00000174552.7 NM_001081426 uc007pkv.1 uc007pkv.2 uc007pkv.3 uc007pkv.4 uc007pkv.5 Belongs to the DIP2 family. molecular_function catalytic activity cellular_component biological_process uc007pkv.1 uc007pkv.2 uc007pkv.3 uc007pkv.4 uc007pkv.5 
ENSMUST00000174558.2 Gm2381 ENSMUST00000174558.2 predicted gene 2381 (from RefSeq NR_046214.1) ENSMUST00000174558.1 G3UY53 G3UY53_MOUSE Gm2381 NR_046214 uc009gmf.1 uc009gmf.2 uc009gmf.3 uc009gmf.4 nucleic acid binding cellular_component uc009gmf.1 uc009gmf.2 uc009gmf.3 uc009gmf.4 
ENSMUST00000174576.4 Psmb9 ENSMUST00000174576.4 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2), transcript variant 1 (from RefSeq NM_013585.3) A0A0R4J256 A0A0R4J256_MOUSE ENSMUST00000174576.1 ENSMUST00000174576.2 ENSMUST00000174576.3 NM_013585 Psmb9 uc008cbs.1 uc008cbs.2 uc008cbs.3 uc008cbs.4 Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; Evidence=; Component of the proteasome complex. Cytoplasm Nucleus Belongs to the peptidase T1B family. proteasome complex immune system process endopeptidase activity threonine-type endopeptidase activity nucleus cytoplasm cytosol proteasome core complex proteolysis peptidase activity hydrolase activity proteolysis involved in cellular protein catabolic process regulation of cysteine-type endopeptidase activity uc008cbs.1 uc008cbs.2 uc008cbs.3 uc008cbs.4 
ENSMUST00000174600.2 Gm20461 ENSMUST00000174600.2 Gm20461 (from geneSymbol) ENSMUST00000174600.1 uc289kfm.1 uc289kfm.2 uc289kfm.1 uc289kfm.2 
ENSMUST00000174621.2 Gm20500 ENSMUST00000174621.2 Gm20500 (from geneSymbol) ENSMUST00000174621.1 uc290xdd.1 uc290xdd.2 uc290xdd.1 uc290xdd.2 
ENSMUST00000174637.2 Vmn1r255 ENSMUST00000174637.2 vomeronasal 1 receptor 255 (from RefSeq NM_001167147.1) ENSMUST00000174637.1 Gm5726 Gm8677 K9J7G9 K9J7G9_MOUSE NM_001167147 Vmn1r245 Vmn1r255 uc012fed.1 uc012fed.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fed.1 uc012fed.2 
ENSMUST00000174641.8 Arhgap32 ENSMUST00000174641.8 Rho GTPase activating protein 32, transcript variant 3 (from RefSeq NM_001370958.1) B9EHJ8 ENSMUST00000174641.1 ENSMUST00000174641.2 ENSMUST00000174641.3 ENSMUST00000174641.4 ENSMUST00000174641.5 ENSMUST00000174641.6 ENSMUST00000174641.7 Grit Kiaa0712 NM_001370958 Q6A010 Q811P8 RHG32_MOUSE Rics uc009orv.1 uc009orv.2 uc009orv.3 uc009orv.4 GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity. Interacts with NTRK1 (via cytoplasmic domain); the interaction is independent of the phosphorylation state of NTRK1 (By similarity). Interacts with SHC3 (via SH2 domain) (By similarity). Interacts with RASA1 (via SH3 domain); the interaction is necessary for the Ras activation and cell transforming activities of ARHGAP32. Interacts with GAB1 and GAB2. Interacts with CRK and CRKL. Found in a complex with CRKL and BCAR1; upon EGF stimulation BCAR1 may be replaced by EGFR (By similarity). Interacts with NCK1 (via SH3 domain); NCK1 recruits phosphorylated BCAR1 to the complex. Isoform 2 interacts with FYN; the interaction appears to be dependent on tyrosine phosphorylation of ARHGAP32 (By similarity). Interacts with EGFR; the interaction requires EGF stimulation and is increased by SHC3. Interacts with CDC42; the interaction requires constitutively active CDC42. Interacts with CTNNB1, DLG4, CDH2 and GRIN2B (By similarity) (PubMed:12531901, PubMed:12857875, PubMed:16716191, PubMed:17272280, PubMed:17663722). Interacts with GPHN (PubMed:27609886). Postsynaptic density Cell projection, dendritic spine Cytoplasm, cell cortex Endosome membrane Golgi apparatus membrane Endoplasmic reticulum membrane Membrane Note=Association to membrane via PX domain (By similarity). Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (PubMed:12531901). Colocalizes with EGFR at the cell membrane upon EGF treatment (By similarity). Colocalizes with GAB2 at the cell membrane (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PX-RICS; IsoId=Q811P8-1; Sequence=Displayed; Name=2; IsoId=Q811P8-2; Sequence=VSP_034937; Isoform 1 and isoform 2 are highly expressed in brain, specially in cortex, corpus striatum, hippocampus and thalamus. Low levels in cerebellum, colon, small intestine, and kidney. Isoform 1 is detectable by embryonic day 13, whereas isoform 2 is detected postnatally. The N-terminal PX domain interacts specifically with phosphatidylinositides. Isoform 2 is phosphorylated on multiple tyrosine residues by FYN (By similarity). Phosphorylated tyrosine residues undergo dephosphorylation after stimulation of NMDA receptors. Phosphorylated in vitro by CaMK2 in the presence of calmodulin and calcium; which inhibits GAP activity. Mice are fertile but display abnormal neurite growth. Belongs to the PX domain-containing GAP family. Golgi membrane fibrillar center GTPase activator activity protein binding nucleoplasm cytoplasm endosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane cell cortex signal transduction small GTPase mediated signal transduction Rho protein signal transduction endosome membrane postsynaptic density actin cytoskeleton membrane cell junction phosphatidylinositol binding cell projection dendritic spine positive regulation of GTPase activity synapse postsynaptic membrane phosphatidylinositol phosphate binding uc009orv.1 uc009orv.2 uc009orv.3 uc009orv.4 
ENSMUST00000174643.2 Vmn1r158 ENSMUST00000174643.2 vomeronasal 1 receptor 158 (from RefSeq NM_001166841.1) ENSMUST00000174643.1 G3UY92 G3UY92_MOUSE NM_001166841 Vmn1r158 uc012fej.1 uc012fej.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fej.1 uc012fej.2 
ENSMUST00000174651.2 Gm20604 ENSMUST00000174651.2 predicted gene 20604 (from RefSeq NM_001142939.1) ENSMUST00000174651.1 F8WIA3 F8WIA3_MOUSE Gm20604 NM_001142939 uc011yqq.1 uc011yqq.2 uc011yqq.3 This locus represents naturally occurring readthrough transcription between the neighboring AK010878 (cDNA sequence AK010878) and Moap1 (modulator of apoptosis 1) genes on chromosome 12. The readthrough transcript encodes a protein that shares sequence identity with the upstream gene product but its C-terminal region is distinct due to frameshifts relative to the downstream gene. [provided by RefSeq, Dec 2011]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.223478.1, AK011927.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 64113, 100233175 ##RefSeq-Attributes-END## EKC/KEOPS complex uc011yqq.1 uc011yqq.2 uc011yqq.3 
ENSMUST00000174663.8 Dtnb ENSMUST00000174663.8 Cytoplasm (from UniProt G3UYM7) AK043436 Dtnb ENSMUST00000174663.1 ENSMUST00000174663.2 ENSMUST00000174663.3 ENSMUST00000174663.4 ENSMUST00000174663.5 ENSMUST00000174663.6 ENSMUST00000174663.7 G3UYM7 G3UYM7_MOUSE uc288eog.1 uc288eog.2 Cytoplasm Belongs to the dystrophin family. Dystrobrevin subfamily. cytoplasm zinc ion binding metal ion binding uc288eog.1 uc288eog.2 
ENSMUST00000174675.4 Or10al5 ENSMUST00000174675.4 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5CZY0) BC090631 ENSMUST00000174675.1 ENSMUST00000174675.2 ENSMUST00000174675.3 Olfr119 Olfr121 Olfr129 Or10al5 Q5CZY0 Q5CZY0_MOUSE uc033hdu.1 uc033hdu.2 uc033hdu.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033hdu.1 uc033hdu.2 uc033hdu.3 
ENSMUST00000174690.2 Gm20456 ENSMUST00000174690.2 Gm20456 (from geneSymbol) ENSMUST00000174690.1 EU234038 uc287wxv.1 uc287wxv.2 uc287wxv.1 uc287wxv.2 
ENSMUST00000174694.8 Gm49361 ENSMUST00000174694.8 Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; (from UniProt G3UXG3) AK029242 ENSMUST00000174694.1 ENSMUST00000174694.2 ENSMUST00000174694.3 ENSMUST00000174694.4 ENSMUST00000174694.5 ENSMUST00000174694.6 ENSMUST00000174694.7 G3UXG3 G3UXG3_MOUSE Gm49361 uc288uvk.1 uc288uvk.2 Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; protein kinase activity ATP binding protein phosphorylation uc288uvk.1 uc288uvk.2 
ENSMUST00000174697.2 Tmem229b ENSMUST00000174697.2 Membrane ; Multi-pass membrane protein (from UniProt Q8BFQ2) AK033403 ENSMUST00000174697.1 Q3UDU2 Q6AXE5 Q8BFQ2 Q8CCD3 T229B_MOUSE TMEM229B uc033gdz.1 uc033gdz.2 uc033gdz.3 Membrane ; Multi-pass membrane protein Belongs to the TMEM229 family. Sequence=BAC28272.1; Type=Frameshift; Evidence=; molecular_function cellular_component response to bacterium membrane integral component of membrane uc033gdz.1 uc033gdz.2 uc033gdz.3 
ENSMUST00000174699.8 H2-Q6 ENSMUST00000174699.8 histocompatibility 2, Q region locus 6, transcript variant 2 (from RefSeq NM_207648.2) ENSMUST00000174699.1 ENSMUST00000174699.2 ENSMUST00000174699.3 ENSMUST00000174699.4 ENSMUST00000174699.5 ENSMUST00000174699.6 ENSMUST00000174699.7 H2-Q6 NM_207648 P79568 P79568_MOUSE uc008chr.1 uc008chr.2 uc008chr.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response external side of plasma membrane cell surface integral component of membrane beta-2-microglobulin binding peptide binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex TAP binding protein heterodimerization activity endoplasmic reticulum exit site uc008chr.1 uc008chr.2 uc008chr.3 
ENSMUST00000174728.4 BC023719 ENSMUST00000174728.4 cDNA sequence BC023719 (from RefSeq NR_165816.1) ENSMUST00000174728.1 ENSMUST00000174728.2 ENSMUST00000174728.3 NR_165816 uc008ckf.1 uc008ckf.2 uc008ckf.3 uc008ckf.4 uc008ckf.1 uc008ckf.2 uc008ckf.3 uc008ckf.4 
ENSMUST00000174738.2 Gm20402 ENSMUST00000174738.2 Gm20402 (from geneSymbol) ENSMUST00000174738.1 uc290fep.1 uc290fep.2 uc290fep.1 uc290fep.2 
ENSMUST00000174742.3 Esp31 ENSMUST00000174742.3 exocrine gland secreted peptide 31 (from RefSeq NM_001177586.1) A8R0W3 A8R0W3_MOUSE ENSMUST00000174742.1 ENSMUST00000174742.2 Esp31 Gm20516 NM_001177586 uc012ate.1 uc012ate.2 pheromone activity extracellular space biological_process uc012ate.1 uc012ate.2 
ENSMUST00000174760.2 Gm20416 ENSMUST00000174760.2 Gm20416 (from geneSymbol) AK006740 ENSMUST00000174760.1 uc292ejg.1 uc292ejg.2 uc292ejg.1 uc292ejg.2 
ENSMUST00000174766.2 L3mbtl3 ENSMUST00000174766.2 L3MBTL3 histone methyl-lysine binding protein, transcript variant 1 (from RefSeq NM_172787.4) ENSMUST00000174766.1 L3mbtl3 LMBL3_MOUSE Mbt1 NM_172787 Q0VGT0 Q641L7 Q6ZPI2 Q8BLB7 Q8C0G4 uc007esb.1 uc007esb.2 Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (By similarity). Involved in the regulation of ubiquitin- dependent degradation of a set of methylated non-histone proteins, including SOX2. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:30442713). Also involved in the regulation of ubiquitin- dependent degradation of methylated DNMT1 and E2F1 (By similarity). Required for normal maturation of myeloid progenitor cells. Interacts with RNF2. Interacts (via SAM domain) with SAMD1 (via SAM domain); the interaction mediates L3MBTL3 binding to chromatin (PubMed:33980486). Interacts with RBPJ; the interaction is required for L3MBTL3 localization to chromatin and is impaired the Notch-derived peptides containing the intracellular domain (NICD) (PubMed:29030483). Interacts (via SAM domain) with KDM1A (By similarity). Interacts with DCAF5 (PubMed:30442713). Interacts with DNMT1 (By similarity). Interacts with E2F1 (By similarity). Interacts with SOX2 (PubMed:30442713). Interacts with SFMBT1 (PubMed:30442713). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BLB7-1; Sequence=Displayed; Name=2; IsoId=Q8BLB7-2; Sequence=VSP_013509; Name=3; IsoId=Q8BLB7-3; Sequence=VSP_013510, VSP_013511; Detected in hematopoietic progenitor cells in fetal liver. Detected in adult bone marrow, heart, brain, spleen, lung, liver, kidney and testis. Death at a late embryonic stage due defective erythropoiesis, defects in the maturation of other types of myeloid lineage cells and anemia. transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleolus chromatin organization regulation of transcription, DNA-templated zinc ion binding myeloid cell differentiation macrophage differentiation granulocyte differentiation erythrocyte maturation uc007esb.1 uc007esb.2 
ENSMUST00000174768.2 Gm20465 ENSMUST00000174768.2 Gm20465 (from geneSymbol) AK138059 ENSMUST00000174768.1 uc290umx.1 uc290umx.2 uc290umx.1 uc290umx.2 
ENSMUST00000174775.2 Vmn1r256 ENSMUST00000174775.2 vomeronasal 1 receptor 256 (from RefSeq NM_001167162.1) ENSMUST00000174775.1 Gm4141 Gm4201 K9J7H2 K9J7H2_MOUSE NM_001167162 Vmn1r246 Vmn1r256 uc012fee.1 uc012fee.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fee.1 uc012fee.2 
ENSMUST00000174806.9 Snx14 ENSMUST00000174806.9 sorting nexin 14, transcript variant 2 (from RefSeq NM_001359958.2) ENSMUST00000174806.1 ENSMUST00000174806.2 ENSMUST00000174806.3 ENSMUST00000174806.4 ENSMUST00000174806.5 ENSMUST00000174806.6 ENSMUST00000174806.7 ENSMUST00000174806.8 G3UX33 G3UX33_MOUSE NM_001359958 Snx14 uc292jks.1 uc292jks.2 Belongs to the sorting nexin family. membrane integral component of membrane phosphatidylinositol binding phosphatidylinositol-3,5-bisphosphate binding uc292jks.1 uc292jks.2 
ENSMUST00000174811.2 Gm3363 ENSMUST00000174811.2 predicted gene 3363 (from RefSeq NR_126079.1) ENSMUST00000174811.1 NR_126079 uc056zld.1 uc056zld.2 uc056zld.3 uc056zld.1 uc056zld.2 uc056zld.3 
ENSMUST00000174836.8 Setd1b ENSMUST00000174836.8 Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (PubMed:29916805). (from UniProt Q8CFT2) BC038367 ENSMUST00000174836.1 ENSMUST00000174836.2 ENSMUST00000174836.3 ENSMUST00000174836.4 ENSMUST00000174836.5 ENSMUST00000174836.6 ENSMUST00000174836.7 Kiaa1076 Q80TK9 Q8CFQ8 Q8CFT2 Q8CGD1 SET1B_MOUSE Set1b uc012edd.1 uc012edd.2 uc012edd.3 Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (PubMed:29916805). Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265; Evidence=; Reaction=N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60268, Rhea:RHEA-COMP:15540, Rhea:RHEA- COMP:15543, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60269; Evidence=; Reaction=N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L- methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60272, Rhea:RHEA- COMP:15537, Rhea:RHEA-COMP:15540, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961, ChEBI:CHEBI:61976; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60273; Evidence=; Component of the SET1B/COMPASS complex composed of the catalytic subunit SETD1A, WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1, DPY30 homotrimer and BOD1. Forms a core complex with the evolutionary conserved subcomplex WRAD composed of WDR5, RBBP5, ASH2L/ASH2 and DPY30 subunits; WRAD differentially stimulates the methyltransferase activity. Interacts with HCFC1 and ASH2L/ASH2. Interacts (via the RRM domain) with WDR82. Interacts (via the RRM domain) with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) only in the presence of WDR82. Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad. Interacts with RBM15. Interacts (via WIN motif) with WDR5. Nucleus Nucleus speckle Chromosome Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SETD1B each bind to a unique set of target genes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CFT2-1; Sequence=Displayed; Name=2; IsoId=Q8CFT2-2; Sequence=VSP_030851; Widely expressed. During preimplantation development expressed through all stages from oocyte to blastocyst. High expression is detected in oocyte that declines to a stable level from the 8-cell stage until 8.5 dpc. Expressed in the blastocyst in both the inner cell mass and the trophectoderm. Mutant embryos show growth retardation from 7.5 dpc and die before 11.5 dpc. Belongs to the class V-like SAM-binding methyltransferase superfamily. molecular_function nucleic acid binding RNA binding nucleus nucleoplasm chromosome cytosol chromatin organization methyltransferase activity nuclear speck transferase activity histone-lysine N-methyltransferase activity methylation histone methyltransferase complex histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex histone H3-K4 methylation uc012edd.1 uc012edd.2 uc012edd.3 
ENSMUST00000174850.8 Rfx3 ENSMUST00000174850.8 regulatory factor X, 3 (influences HLA class II expression), transcript variant 1 (from RefSeq NM_011265.3) ENSMUST00000174850.1 ENSMUST00000174850.2 ENSMUST00000174850.3 ENSMUST00000174850.4 ENSMUST00000174850.5 ENSMUST00000174850.6 ENSMUST00000174850.7 NM_011265 P48381 Q8BLW2 Q8C0R3 Q8VBY6 RFX3_MOUSE uc008hcb.1 uc008hcb.2 uc008hcb.3 uc008hcb.4 Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells (PubMed:15121860, PubMed:19671664). Also required for ciliated ependymal cell differentiation (PubMed:16930429). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells (PubMed:17229940). Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (By similarity). Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5). Represses transcription of MAP1A in non- neuronal cells but not in neuronal cells. Heterodimer; heterodimerizes with RFX1 and RFX2, and RFX6. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48381-1; Sequence=Displayed; Name=2; IsoId=P48381-2; Sequence=VSP_007628, VSP_007629, VSP_007630; Expressed in ciliated cells of the node and in the ciliated ependymal cells of the subcommissural organ (SCO), choroid plexuses (CP) and ventricular walls during embryonic and postnatal development. Expressed in developing and mature pancreatic endocrine cells during embryogenesis and in adults (at protein level). High rate of embryonic lethality. 2 peaks of death are observed: approximately half of the embryos die around days 11 or 12 of embryonic development. Of the embryos that survive past this stage, approximately two-thirds die at birth. Surviving mice are systematically smaller. Their body weights at birth are approximately one-third lower. This growth retardation increases with age, and the body weights that adult male or female mice attain are less than half those of wild-type mice. Mice exhibit a pronounced defect in nodal cilia: cilia are present but remain markedly stunted. Mice also suffer from hydrocephalus without stenosis of the aqueduct of Sylvius. In pancreatic endocrine cells, primary cilia are reduced in number and severely stunted: this ciliary abnormality is associated with a developmental defect leading to an altered cellular composition of the islets of Langerhans. Just before birth, islets contain considerably less insulin-, glucagon-, and ghrelin-producing cells, whereas pancreatic PP (polypeptide-producing) cells are markedly increased in number. In adult mice, the defect leads to small and disorganized islets, reduced insulin production, and impaired glucose tolerance. Belongs to the RFX family. nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding extracellular region nucleus transcription factor complex transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development determination of left/right symmetry cell differentiation endocrine pancreas development sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell maturation regulation of insulin secretion cilium assembly cilium-dependent cell motility epithelial cilium movement involved in determination of left/right asymmetry type B pancreatic cell maturation positive regulation of type B pancreatic cell development uc008hcb.1 uc008hcb.2 uc008hcb.3 uc008hcb.4 
ENSMUST00000174851.2 Gm26940 ENSMUST00000174851.2 Gm26940 (from geneSymbol) DQ311526 ENSMUST00000174851.1 uc289kad.1 uc289kad.2 uc289kad.1 uc289kad.2 
ENSMUST00000174861.2 Gm20531 ENSMUST00000174861.2 Gm20531 (from geneSymbol) AK048048 ENSMUST00000174861.1 uc009drm.1 uc009drm.2 uc009drm.1 uc009drm.2 
ENSMUST00000174884.3 Gm20475 ENSMUST00000174884.3 Gm20475 (from geneSymbol) ENSMUST00000174884.1 ENSMUST00000174884.2 uc290vip.1 uc290vip.2 uc290vip.3 uc290vip.1 uc290vip.2 uc290vip.3 
ENSMUST00000174892.3 Mir3962 ENSMUST00000174892.3 microRNA 3962 (from RefSeq NR_039539.1) ENSMUST00000174892.1 ENSMUST00000174892.2 NR_039539 uc056yfv.1 uc056yfv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yfv.1 uc056yfv.2 
ENSMUST00000174896.3 Mir3471-2 ENSMUST00000174896.3 microRNA 3471-2 (from RefSeq NR_037306.1) ENSMUST00000174896.1 ENSMUST00000174896.2 NR_037306 uc056zuz.1 uc056zuz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zuz.1 uc056zuz.2 
ENSMUST00000174897.3 Mir5112 ENSMUST00000174897.3 microRNA 5112 (from RefSeq NR_039572.1) ENSMUST00000174897.1 ENSMUST00000174897.2 NR_039572 uc029tqi.1 uc029tqi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446412.1 [ECO:0000345] ##Evidence-Data-END## uc029tqi.1 uc029tqi.2 
ENSMUST00000174898.3 Mir3964 ENSMUST00000174898.3 microRNA 3964 (from RefSeq NR_039542.1) ENSMUST00000174898.1 ENSMUST00000174898.2 NR_039542 uc056yyh.1 uc056yyh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yyh.1 uc056yyh.2 
ENSMUST00000174911.3 Mir3104 ENSMUST00000174911.3 microRNA 3104 (from RefSeq NR_037291.1) ENSMUST00000174911.1 ENSMUST00000174911.2 NR_037291 uc029wpv.1 uc029wpv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610947.1 [ECO:0000345] ##Evidence-Data-END## uc029wpv.1 uc029wpv.2 
ENSMUST00000174918.3 Mir3100 ENSMUST00000174918.3 microRNA 3100 (from RefSeq NR_037282.1) ENSMUST00000174918.1 ENSMUST00000174918.2 NR_037282 uc012fay.1 uc012fay.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610939.1 [ECO:0000345] ##Evidence-Data-END## uc012fay.1 uc012fay.2 
ENSMUST00000174922.4 Mir344h-1 ENSMUST00000174922.4 microRNA 344h-1 (from RefSeq NR_049201.1) ENSMUST00000174922.1 ENSMUST00000174922.2 ENSMUST00000174922.3 NR_049201 uc033izw.1 uc033izw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611596.1, LM611597.1 [ECO:0000345] ##Evidence-Data-END## uc033izw.1 uc033izw.2 
ENSMUST00000174924.4 Rn7s2 ENSMUST00000174924.4 7S RNA 2 (from RefSeq NR_052008.1) ENSMUST00000174924.1 ENSMUST00000174924.2 ENSMUST00000174924.3 NR_052008 uc057koh.1 uc057koh.2 uc057koh.3 uc057koh.1 uc057koh.2 uc057koh.3 
ENSMUST00000174932.3 Mir3067 ENSMUST00000174932.3 microRNA 3067 (from RefSeq NR_037227.1) ENSMUST00000174932.1 ENSMUST00000174932.2 NR_037227 uc011yok.1 uc011yok.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610877.1 [ECO:0000345] ##Evidence-Data-END## uc011yok.1 uc011yok.2 
ENSMUST00000174933.5 Gm24105 ENSMUST00000174933.5 Gm24105 (from geneSymbol) AB351005 ENSMUST00000174933.1 ENSMUST00000174933.2 ENSMUST00000174933.3 ENSMUST00000174933.4 uc291bzn.1 uc291bzn.2 uc291bzn.1 uc291bzn.2 
ENSMUST00000174936.2 Mir5106 ENSMUST00000174936.2 microRNA 5106 (from RefSeq NR_039565.1) ENSMUST00000174936.1 NR_039565 uc029uua.1 uc029uua.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446405.1, LM611518.1 [ECO:0000345] ##Evidence-Data-END## uc029uua.1 uc029uua.2 
ENSMUST00000174938.3 Mir5129 ENSMUST00000174938.3 microRNA 5129 (from RefSeq NR_039591.1) ENSMUST00000174938.1 ENSMUST00000174938.2 NR_039591 uc029txb.1 uc029txb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446432.1, LM611532.1 [ECO:0000345] ##Evidence-Data-END## uc029txb.1 uc029txb.2 
ENSMUST00000174939.3 Snord55 ENSMUST00000174939.3 small nucleolar RNA, C/D box 55 (from RefSeq NR_030704.1) ENSMUST00000174939.1 ENSMUST00000174939.2 NR_030704 uc012djs.1 uc012djs.2 uc012djs.3 uc012djs.1 uc012djs.2 uc012djs.3 
ENSMUST00000174946.3 Gm25744 ENSMUST00000174946.3 Gm25744 (from geneSymbol) ENSMUST00000174946.1 ENSMUST00000174946.2 uc289kiy.1 uc289kiy.2 uc289kiy.1 uc289kiy.2 
ENSMUST00000174954.3 Mir3092 ENSMUST00000174954.3 microRNA 3092 (from RefSeq NR_037275.1) ENSMUST00000174954.1 ENSMUST00000174954.2 NR_037275 uc012coa.1 uc012coa.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610933.1 [ECO:0000345] ##Evidence-Data-END## uc012coa.1 uc012coa.2 
ENSMUST00000174955.3 Mir5133 ENSMUST00000174955.3 microRNA 5133 (from RefSeq NR_039595.1) ENSMUST00000174955.1 ENSMUST00000174955.2 NR_039595 uc029xbp.1 uc029xbp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446436.1, LM611535.1 [ECO:0000345] ##Evidence-Data-END## uc029xbp.1 uc029xbp.2 
ENSMUST00000174961.5 Gm24514 ENSMUST00000174961.5 Gm24514 (from geneSymbol) AB350756 ENSMUST00000174961.1 ENSMUST00000174961.2 ENSMUST00000174961.3 ENSMUST00000174961.4 uc289pdw.1 uc289pdw.2 uc289pdw.1 uc289pdw.2 
ENSMUST00000174963.3 Gm24512 ENSMUST00000174963.3 Gm24512 (from geneSymbol) ENSMUST00000174963.1 ENSMUST00000174963.2 uc290tmu.1 uc290tmu.2 uc290tmu.1 uc290tmu.2 
ENSMUST00000174969.3 Gm22857 ENSMUST00000174969.3 Gm22857 (from geneSymbol) ENSMUST00000174969.1 ENSMUST00000174969.2 uc291ztx.1 uc291ztx.2 uc291ztx.1 uc291ztx.2 
ENSMUST00000174972.3 Gm22858 ENSMUST00000174972.3 Gm22858 (from geneSymbol) ENSMUST00000174972.1 ENSMUST00000174972.2 uc289mrn.1 uc289mrn.2 uc289mrn.1 uc289mrn.2 
ENSMUST00000174986.3 Mir3062 ENSMUST00000174986.3 microRNA 3062 (from RefSeq NR_037222.1) ENSMUST00000174986.1 ENSMUST00000174986.2 NR_037222 uc287zea.1 uc287zea.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610872.1 [ECO:0000345] ##Evidence-Data-END## uc287zea.1 uc287zea.2 
ENSMUST00000174989.3 Snora24 ENSMUST00000174989.3 small nucleolar RNA, H/ACA box 24 (from RefSeq NR_028573.1) ENSMUST00000174989.1 ENSMUST00000174989.2 NR_028573 uc290jji.1 uc290jji.2 uc290jji.1 uc290jji.2 
ENSMUST00000174993.3 Mir5100 ENSMUST00000174993.3 microRNA 5100 (from RefSeq NR_039559.1) ENSMUST00000174993.1 ENSMUST00000174993.2 NR_039559 uc029rlz.1 uc029rlz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446399.1, LM611515.1 [ECO:0000345] ##Evidence-Data-END## uc029rlz.1 uc029rlz.2 
ENSMUST00000174997.3 Mir5135 ENSMUST00000174997.3 microRNA 5135 (from RefSeq NR_039597.1) ENSMUST00000174997.1 ENSMUST00000174997.2 NR_039597 uc029rto.1 uc029rto.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446438.1, LM611537.1 [ECO:0000345] ##Evidence-Data-END## uc029rto.1 uc029rto.2 
ENSMUST00000175000.4 Mir3074-1 ENSMUST00000175000.4 microRNA 3074-1 (from RefSeq NR_037235.1) ENSMUST00000175000.1 ENSMUST00000175000.2 ENSMUST00000175000.3 NR_037235 uc011zaw.1 uc011zaw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610885.1 [ECO:0000345] ##Evidence-Data-END## uc011zaw.1 uc011zaw.2 
ENSMUST00000175002.3 Gm22177 ENSMUST00000175002.3 Gm22177 (from geneSymbol) ENSMUST00000175002.1 ENSMUST00000175002.2 uc291sef.1 uc291sef.2 uc291sef.1 uc291sef.2 
ENSMUST00000175004.3 Mir5122 ENSMUST00000175004.3 microRNA 5122 (from RefSeq NR_039582.1) ENSMUST00000175004.1 ENSMUST00000175004.2 NR_039582 uc029uzt.1 uc029uzt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446422.1, LM611526.1 [ECO:0000345] ##Evidence-Data-END## uc029uzt.1 uc029uzt.2 
ENSMUST00000175005.5 Rn7s6 ENSMUST00000175005.5 Rn7s6 (from geneSymbol) DQ567581 ENSMUST00000175005.1 ENSMUST00000175005.2 ENSMUST00000175005.3 ENSMUST00000175005.4 uc291flg.1 uc291flg.2 uc291flg.1 uc291flg.2 
ENSMUST00000175006.4 Gm22180 ENSMUST00000175006.4 Gm22180 (from geneSymbol) ENSMUST00000175006.1 ENSMUST00000175006.2 ENSMUST00000175006.3 uc290qzj.1 uc290qzj.2 uc290qzj.1 uc290qzj.2 
ENSMUST00000175010.3 Mir3080 ENSMUST00000175010.3 microRNA 3080 (from RefSeq NR_037241.1) ENSMUST00000175010.1 ENSMUST00000175010.2 NR_037241 uc056yzs.1 uc056yzs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yzs.1 uc056yzs.2 
ENSMUST00000175011.3 Mir3473a ENSMUST00000175011.3 microRNA 3473a (from RefSeq NR_037311.1) ENSMUST00000175011.1 ENSMUST00000175011.2 NR_037311 uc057atm.1 uc057atm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611143.1 [ECO:0000345] ##Evidence-Data-END## uc057atm.1 uc057atm.2 
ENSMUST00000175020.2 Mir5120 ENSMUST00000175020.2 microRNA 5120 (from RefSeq NR_039580.1) ENSMUST00000175020.1 NR_039580 uc056zvx.1 uc056zvx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zvx.1 uc056zvx.2 
ENSMUST00000175024.5 Mir3154 ENSMUST00000175024.5 microRNA 3154 (from RefSeq NR_128563.1) ENSMUST00000175024.1 ENSMUST00000175024.2 ENSMUST00000175024.3 ENSMUST00000175024.4 NR_128563 uc056zly.1 uc056zly.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zly.1 uc056zly.2 
ENSMUST00000175029.3 Mirlet7a-2 ENSMUST00000175029.3 microRNA let7a-2 (from RefSeq NR_029726.1) ENSMUST00000175029.1 ENSMUST00000175029.2 NR_029726 uc012grm.1 uc012grm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608555.1 [ECO:0000345] ##Evidence-Data-END## uc012grm.1 uc012grm.2 
ENSMUST00000175032.4 Rn7s1 ENSMUST00000175032.4 7S RNA 1 (from RefSeq NR_052007.1) ENSMUST00000175032.1 ENSMUST00000175032.2 ENSMUST00000175032.3 NR_052007 uc288gwy.1 uc288gwy.2 uc288gwy.1 uc288gwy.2 
ENSMUST00000175040.3 Mir3057 ENSMUST00000175040.3 microRNA 3057 (from RefSeq NR_037218.1) ENSMUST00000175040.1 ENSMUST00000175040.2 NR_037218 uc011xje.1 uc011xje.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610868.1 [ECO:0000345] ##Evidence-Data-END## uc011xje.1 uc011xje.2 
ENSMUST00000175042.3 Gm23647 ENSMUST00000175042.3 Gm23647 (from geneSymbol) ENSMUST00000175042.1 ENSMUST00000175042.2 uc292dzi.1 uc292dzi.2 uc292dzi.1 uc292dzi.2 
ENSMUST00000175043.3 Mir3077 ENSMUST00000175043.3 microRNA 3077 (from RefSeq NR_037238.1) ENSMUST00000175043.1 ENSMUST00000175043.2 NR_037238 uc011zmh.1 uc011zmh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610888.1 [ECO:0000345] ##Evidence-Data-END## uc011zmh.1 uc011zmh.2 
ENSMUST00000175046.3 Mir5116 ENSMUST00000175046.3 microRNA 5116 (from RefSeq NR_039576.1) ENSMUST00000175046.1 ENSMUST00000175046.2 NR_039576 uc029xke.1 uc029xke.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446416.1, LM611523.1 [ECO:0000345] ##Evidence-Data-END## uc029xke.1 uc029xke.2 
ENSMUST00000175052.3 Mir466m ENSMUST00000175052.3 microRNA 466m (from RefSeq NR_130333.1) ENSMUST00000175052.1 ENSMUST00000175052.2 NR_130333 uc056zji.1 uc056zji.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zji.1 uc056zji.2 
ENSMUST00000175053.3 Mir3110 ENSMUST00000175053.3 microRNA 3110 (from RefSeq NR_037297.1) ENSMUST00000175053.1 ENSMUST00000175053.2 NR_037297 uc057ara.1 uc057ara.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057ara.1 uc057ara.2 
ENSMUST00000175064.4 Gm26461 ENSMUST00000175064.4 Gm26461 (from geneSymbol) AB350756 ENSMUST00000175064.1 ENSMUST00000175064.2 ENSMUST00000175064.3 uc292jlr.1 uc292jlr.2 uc292jlr.1 uc292jlr.2 
ENSMUST00000175066.3 Mir199b ENSMUST00000175066.3 microRNA 199b (from RefSeq NR_029811.1) ENSMUST00000175066.1 ENSMUST00000175066.2 NR_029811 uc012btv.1 uc012btv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608641.1 [ECO:0000345] ##Evidence-Data-END## uc012btv.1 uc012btv.2 
ENSMUST00000175072.3 Mir3086 ENSMUST00000175072.3 microRNA 3086 (from RefSeq NR_037247.1) ENSMUST00000175072.1 ENSMUST00000175072.2 NR_037247 uc012boa.1 uc012boa.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610897.1 [ECO:0000345] ##Evidence-Data-END## uc012boa.1 uc012boa.2 
ENSMUST00000175074.3 Mir3099 ENSMUST00000175074.3 microRNA 3099 (from RefSeq NR_037213.1) ENSMUST00000175074.1 ENSMUST00000175074.2 NR_037213 uc012exn.1 uc012exn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609667.1 [ECO:0000345] ##Evidence-Data-END## uc012exn.1 uc012exn.2 
ENSMUST00000175078.3 Gm23639 ENSMUST00000175078.3 Gm23639 (from geneSymbol) ENSMUST00000175078.1 ENSMUST00000175078.2 LF201355 uc289ope.1 uc289ope.2 uc289ope.1 uc289ope.2 
ENSMUST00000175086.3 Mir3091 ENSMUST00000175086.3 microRNA 3091 (from RefSeq NR_037274.1) ENSMUST00000175086.1 ENSMUST00000175086.2 NR_037274 uc012cly.1 uc012cly.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610932.1 [ECO:0000345] ##Evidence-Data-END## uc012cly.1 uc012cly.2 
ENSMUST00000175089.3 Mir3963 ENSMUST00000175089.3 microRNA 3963 (from RefSeq NR_039540.1) ENSMUST00000175089.1 ENSMUST00000175089.2 NR_039540 uc056zuv.1 uc056zuv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zuv.1 uc056zuv.2 
ENSMUST00000175091.3 Mir3088 ENSMUST00000175091.3 microRNA 3088 (from RefSeq NR_037271.1) ENSMUST00000175091.1 ENSMUST00000175091.2 NR_037271 uc012btb.1 uc012btb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610929.1 [ECO:0000345] ##Evidence-Data-END## uc012btb.1 uc012btb.2 
ENSMUST00000175096.3 Rpph1 ENSMUST00000175096.3 ribonuclease P RNA component H1 (from RefSeq NR_002142.2) ENSMUST00000175096.1 ENSMUST00000175096.2 NR_002142 uc029six.1 uc029six.2 uc029six.3 uc029six.1 uc029six.2 uc029six.3 
ENSMUST00000175106.3 Mir344d-1 ENSMUST00000175106.3 microRNA 344d-1 (from RefSeq NR_037215.1) ENSMUST00000175106.1 ENSMUST00000175106.2 NR_037215 uc012fma.1 uc012fma.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609670.1 [ECO:0000345] ##Evidence-Data-END## uc012fma.1 uc012fma.2 
ENSMUST00000175109.3 Mir344g ENSMUST00000175109.3 microRNA 344g (from RefSeq NR_037287.1) ENSMUST00000175109.1 ENSMUST00000175109.2 NR_037287 uc012fmj.1 uc012fmj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610944.1 [ECO:0000345] ##Evidence-Data-END## uc012fmj.1 uc012fmj.2 
ENSMUST00000175111.3 Mir5103 ENSMUST00000175111.3 microRNA 5103 (from RefSeq NR_039562.1) ENSMUST00000175111.1 ENSMUST00000175111.2 NR_039562 uc029qns.1 uc029qns.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446402.1, LM611516.1 [ECO:0000345] ##Evidence-Data-END## uc029qns.1 uc029qns.2 
ENSMUST00000175121.2 Mir3094 ENSMUST00000175121.2 microRNA 3094 (from RefSeq NR_037277.1) ENSMUST00000175121.1 NR_037277 uc012dbz.1 uc012dbz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610935.1 [ECO:0000345] ##Evidence-Data-END## uc012dbz.1 uc012dbz.2 
ENSMUST00000175126.3 Mir3058 ENSMUST00000175126.3 microRNA 3058 (from RefSeq NR_037212.1) ENSMUST00000175126.1 ENSMUST00000175126.2 NR_037212 uc011xme.1 uc011xme.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609666.1 [ECO:0000345] ##Evidence-Data-END## uc011xme.1 uc011xme.2 
ENSMUST00000175127.3 Mir5113 ENSMUST00000175127.3 microRNA 5113 (from RefSeq NR_039573.1) ENSMUST00000175127.1 ENSMUST00000175127.2 NR_039573 uc029stu.1 uc029stu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446413.1, LM611521.1 [ECO:0000345] ##Evidence-Data-END## uc029stu.1 uc029stu.2 
ENSMUST00000175128.3 Gm25632 ENSMUST00000175128.3 Gm25632 (from geneSymbol) ENSMUST00000175128.1 ENSMUST00000175128.2 LF193251 uc289uzv.1 uc289uzv.2 uc289uzv.1 uc289uzv.2 
ENSMUST00000175129.3 Mir3061 ENSMUST00000175129.3 microRNA 3061 (from RefSeq NR_037221.1) ENSMUST00000175129.1 ENSMUST00000175129.2 NR_037221 uc011xun.1 uc011xun.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610871.1 [ECO:0000345] ##Evidence-Data-END## uc011xun.1 uc011xun.2 
ENSMUST00000175134.4 Gm22649 ENSMUST00000175134.4 Gm22649 (from geneSymbol) ENSMUST00000175134.1 ENSMUST00000175134.2 ENSMUST00000175134.3 uc291ldq.1 uc291ldq.2 uc291ldq.1 uc291ldq.2 
ENSMUST00000175138.3 Mir3552 ENSMUST00000175138.3 microRNA 3552 (from RefSeq NR_128564.1) ENSMUST00000175138.1 ENSMUST00000175138.2 NR_128564 uc057atc.1 uc057atc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057atc.1 uc057atc.2 
ENSMUST00000175139.2 Mir3471-1 ENSMUST00000175139.2 microRNA 3471-1 (from RefSeq NR_037304.1) ENSMUST00000175139.1 NR_037304 uc056zvb.1 uc056zvb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zvb.1 uc056zvb.2 
ENSMUST00000175144.4 Gm22123 ENSMUST00000175144.4 Gm22123 (from geneSymbol) ENSMUST00000175144.1 ENSMUST00000175144.2 ENSMUST00000175144.3 uc287wne.1 uc287wne.2 uc287wne.1 uc287wne.2 
ENSMUST00000175146.3 Snord53 ENSMUST00000175146.3 small nucleolar RNA, C/D box 53 (from RefSeq NR_028551.2) ENSMUST00000175146.1 ENSMUST00000175146.2 NR_028551 uc057kyq.1 uc057kyq.2 uc057kyq.3 uc057kyq.1 uc057kyq.2 uc057kyq.3 
ENSMUST00000175147.3 Gm22122 ENSMUST00000175147.3 Gm22122 (from geneSymbol) ENSMUST00000175147.1 ENSMUST00000175147.2 uc291eel.1 uc291eel.2 uc291eel.1 uc291eel.2 
ENSMUST00000175160.3 Mir5130 ENSMUST00000175160.3 microRNA 5130 (from RefSeq NR_039592.1) ENSMUST00000175160.1 ENSMUST00000175160.2 NR_039592 uc288wgn.1 uc288wgn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446433.1, LM611533.1 [ECO:0000345] ##Evidence-Data-END## uc288wgn.1 uc288wgn.2 
ENSMUST00000175164.5 Gm25735 ENSMUST00000175164.5 Gm25735 (from geneSymbol) ENSMUST00000175164.1 ENSMUST00000175164.2 ENSMUST00000175164.3 ENSMUST00000175164.4 uc291vsp.1 uc291vsp.2 uc291vsp.1 uc291vsp.2 
ENSMUST00000175166.3 Mir5132 ENSMUST00000175166.3 microRNA 5132 (from RefSeq NR_039594.1) ENSMUST00000175166.1 ENSMUST00000175166.2 NR_039594 uc029xkq.1 uc029xkq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446435.1, LM611534.1 [ECO:0000345] ##Evidence-Data-END## uc029xkq.1 uc029xkq.2 
ENSMUST00000175171.3 Gm24086 ENSMUST00000175171.3 Gm24086 (from geneSymbol) ENSMUST00000175171.1 ENSMUST00000175171.2 LF192893 uc287mdc.1 uc287mdc.2 uc287mdc.1 uc287mdc.2 
ENSMUST00000175180.3 Mir344b ENSMUST00000175180.3 microRNA 344b (from RefSeq NR_037285.1) ENSMUST00000175180.1 ENSMUST00000175180.2 NR_037285 uc012fme.1 uc012fme.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610942.1 [ECO:0000345] ##Evidence-Data-END## uc012fme.1 uc012fme.2 
ENSMUST00000175181.3 Mir5101 ENSMUST00000175181.3 microRNA 5101 (from RefSeq NR_039560.1) ENSMUST00000175181.1 ENSMUST00000175181.2 NR_039560 uc029rtn.1 uc029rtn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446400.1 [ECO:0000345] ##Evidence-Data-END## uc029rtn.1 uc029rtn.2 
ENSMUST00000175205.4 Mir3070b ENSMUST00000175205.4 microRNA 3070b (from RefSeq NR_037231.1) ENSMUST00000175205.1 ENSMUST00000175205.2 ENSMUST00000175205.3 NR_037231 uc011ysj.1 uc011ysj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610881.1 [ECO:0000345] ##Evidence-Data-END## uc011ysj.1 uc011ysj.2 
ENSMUST00000175211.3 Mir3059 ENSMUST00000175211.3 microRNA 3059 (from RefSeq NR_037211.1) ENSMUST00000175211.1 ENSMUST00000175211.2 NR_037211 uc011xms.1 uc011xms.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609665.1 [ECO:0000345] ##Evidence-Data-END## uc011xms.1 uc011xms.2 
ENSMUST00000175217.3 Mir5128 ENSMUST00000175217.3 microRNA 5128 (from RefSeq NR_039590.1) ENSMUST00000175217.1 ENSMUST00000175217.2 NR_039590 uc056zml.1 uc056zml.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446431.1, LM611531.1 [ECO:0000345] ##Evidence-Data-END## uc056zml.1 uc056zml.2 
ENSMUST00000175231.3 Mir3078 ENSMUST00000175231.3 microRNA 3078 (from RefSeq NR_037239.1) ENSMUST00000175231.1 ENSMUST00000175231.2 NR_037239 uc011znl.1 uc011znl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610889.1 [ECO:0000345] ##Evidence-Data-END## uc011znl.1 uc011znl.2 
ENSMUST00000175233.5 Gm25072 ENSMUST00000175233.5 Gm25072 (from geneSymbol) ENSMUST00000175233.1 ENSMUST00000175233.2 ENSMUST00000175233.3 ENSMUST00000175233.4 uc288znr.1 uc288znr.2 uc288znr.1 uc288znr.2 
ENSMUST00000175240.3 Mir5125 ENSMUST00000175240.3 microRNA 5125 (from RefSeq NR_039586.1) ENSMUST00000175240.1 ENSMUST00000175240.2 NR_039586 uc056zdo.1 uc056zdo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zdo.1 uc056zdo.2 
ENSMUST00000175244.3 Mir378b ENSMUST00000175244.3 microRNA 378b (from RefSeq NR_039545.1) ENSMUST00000175244.1 ENSMUST00000175244.2 NR_039545 uc029rni.1 uc029rni.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611360.1 [ECO:0000345] ##Evidence-Data-END## uc029rni.1 uc029rni.2 
ENSMUST00000175245.5 Gm25574 ENSMUST00000175245.5 Gm25574 (from geneSymbol) ENSMUST00000175245.1 ENSMUST00000175245.2 ENSMUST00000175245.3 ENSMUST00000175245.4 uc290euc.1 uc290euc.2 uc290euc.1 uc290euc.2 
ENSMUST00000175247.3 Mir3093 ENSMUST00000175247.3 microRNA 3093 (from RefSeq NR_037276.1) ENSMUST00000175247.1 ENSMUST00000175247.2 NR_037276 uc012crn.1 uc012crn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610934.1 [ECO:0000345] ##Evidence-Data-END## uc012crn.1 uc012crn.2 
ENSMUST00000175249.3 Mir466q ENSMUST00000175249.3 microRNA 466q (from RefSeq NR_130342.1) ENSMUST00000175249.1 ENSMUST00000175249.2 NR_130342 uc056zrq.1 uc056zrq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zrq.1 uc056zrq.2 
ENSMUST00000175254.3 Mir16-1 ENSMUST00000175254.3 microRNA 16-1 (from RefSeq NR_029734.1) ENSMUST00000175254.1 ENSMUST00000175254.2 NR_029734 uc007ugf.1 uc007ugf.2 uc007ugf.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608563.1 [ECO:0000345] ##Evidence-Data-END## uc007ugf.1 uc007ugf.2 uc007ugf.3 
ENSMUST00000175257.3 Mir5099 ENSMUST00000175257.3 microRNA 5099 (from RefSeq NR_039558.1) ENSMUST00000175257.1 ENSMUST00000175257.2 NR_039558 uc056yqd.1 uc056yqd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yqd.1 uc056yqd.2 
ENSMUST00000175258.3 Gm23921 ENSMUST00000175258.3 Gm23921 (from geneSymbol) ENSMUST00000175258.1 ENSMUST00000175258.2 uc291nbj.1 uc291nbj.2 uc291nbj.1 uc291nbj.2 
ENSMUST00000175261.3 Gm24154 ENSMUST00000175261.3 Gm24154 (from geneSymbol) ENSMUST00000175261.1 ENSMUST00000175261.2 uc291uoe.1 uc291uoe.2 uc291uoe.1 uc291uoe.2 
ENSMUST00000175262.3 Mir3473c ENSMUST00000175262.3 microRNA 3473c (from RefSeq NR_039566.1) ENSMUST00000175262.1 ENSMUST00000175262.2 NR_039566 uc029qvf.1 uc029qvf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446406.1 [ECO:0000345] ##Evidence-Data-END## uc029qvf.1 uc029qvf.2 
ENSMUST00000175266.3 Mir15a ENSMUST00000175266.3 microRNA 15a (from RefSeq NR_029733.1) ENSMUST00000175266.1 ENSMUST00000175266.2 NR_029733 uc011zne.1 uc011zne.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608562.1 [ECO:0000345] ##Evidence-Data-END## uc011zne.1 uc011zne.2 
ENSMUST00000175268.3 Snord52 ENSMUST00000175268.3 small nucleolar RNA, C/D box 52 (from RefSeq NR_028527.1) ENSMUST00000175268.1 ENSMUST00000175268.2 NR_028527 uc289kiw.1 uc289kiw.2 uc289kiw.1 uc289kiw.2 
ENSMUST00000175270.3 Mir100 ENSMUST00000175270.3 microRNA 100 (from RefSeq NR_029790.1) ENSMUST00000175270.1 ENSMUST00000175270.2 NR_029790 uc012grl.1 uc012grl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608620.1 [ECO:0000345] ##Evidence-Data-END## uc012grl.1 uc012grl.2 
ENSMUST00000175276.3 Mir5108 ENSMUST00000175276.3 microRNA 5108 (from RefSeq NR_039568.1) ENSMUST00000175276.1 ENSMUST00000175276.2 NR_039568 uc029qxi.1 uc029qxi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446408.1 [ECO:0000345] ##Evidence-Data-END## uc029qxi.1 uc029qxi.2 
ENSMUST00000175295.3 Mir5127 ENSMUST00000175295.3 microRNA 5127 (from RefSeq NR_039589.1) ENSMUST00000175295.1 ENSMUST00000175295.2 NR_039589 uc029tqg.1 uc029tqg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446430.1 [ECO:0000345] ##Evidence-Data-END## uc029tqg.1 uc029tqg.2 
ENSMUST00000175296.3 Mir3066 ENSMUST00000175296.3 microRNA 3066 (from RefSeq NR_037226.1) ENSMUST00000175296.1 ENSMUST00000175296.2 NR_037226 uc011yko.1 uc011yko.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610876.1 [ECO:0000345] ##Evidence-Data-END## uc011yko.1 uc011yko.2 
ENSMUST00000175298.3 Mir1912 ENSMUST00000175298.3 microRNA 1912 (from RefSeq NR_037300.1) ENSMUST00000175298.1 ENSMUST00000175298.2 NR_037300 uc012hqa.1 uc012hqa.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610956.1 [ECO:0000345] ##Evidence-Data-END## uc012hqa.1 uc012hqa.2 
ENSMUST00000175301.3 Mir3109 ENSMUST00000175301.3 microRNA 3109 (from RefSeq NR_037296.1) ENSMUST00000175301.1 ENSMUST00000175301.2 NR_037296 uc012gwi.1 uc012gwi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610952.1 [ECO:0000345] ##Evidence-Data-END## uc012gwi.1 uc012gwi.2 
ENSMUST00000175303.3 Snord8 ENSMUST00000175303.3 small nucleolar RNA, C/D box 8 (from RefSeq NR_028542.1) ENSMUST00000175303.1 ENSMUST00000175303.2 NR_028542 uc011zkm.1 uc011zkm.2 uc011zkm.3 uc011zkm.1 uc011zkm.2 uc011zkm.3 
ENSMUST00000175305.3 Mir3081 ENSMUST00000175305.3 microRNA 3081 (from RefSeq NR_037242.1) ENSMUST00000175305.1 ENSMUST00000175305.2 NR_037242 uc012agc.1 uc012agc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610892.1 [ECO:0000345] ##Evidence-Data-END## uc012agc.1 uc012agc.2 
ENSMUST00000175315.5 Gm24812 ENSMUST00000175315.5 Gm24812 (from geneSymbol) ENSMUST00000175315.1 ENSMUST00000175315.2 ENSMUST00000175315.3 ENSMUST00000175315.4 uc292pif.1 uc292pif.2 uc292pif.1 uc292pif.2 
ENSMUST00000175318.5 Gm24809 ENSMUST00000175318.5 Gm24809 (from geneSymbol) ENSMUST00000175318.1 ENSMUST00000175318.2 ENSMUST00000175318.3 ENSMUST00000175318.4 uc292nta.1 uc292nta.2 uc292nta.1 uc292nta.2 
ENSMUST00000175319.3 Mir5104 ENSMUST00000175319.3 microRNA 5104 (from RefSeq NR_039563.1) ENSMUST00000175319.1 ENSMUST00000175319.2 NR_039563 uc029qvq.1 uc029qvq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446403.1, LM611517.1 [ECO:0000345] ##Evidence-Data-END## uc029qvq.1 uc029qvq.2 
ENSMUST00000175320.3 Mir5098 ENSMUST00000175320.3 microRNA 5098 (from RefSeq NR_039557.1) ENSMUST00000175320.1 ENSMUST00000175320.2 NR_039557 uc029vit.1 uc029vit.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029vit.1 uc029vit.2 
ENSMUST00000175323.5 Gm23153 ENSMUST00000175323.5 Gm23153 (from geneSymbol) ENSMUST00000175323.1 ENSMUST00000175323.2 ENSMUST00000175323.3 ENSMUST00000175323.4 uc287oxj.1 uc287oxj.2 uc287oxj.1 uc287oxj.2 
ENSMUST00000175332.3 Mir124a-2 ENSMUST00000175332.3 microRNA 124a-2 (from RefSeq NR_029814.1) ENSMUST00000175332.1 ENSMUST00000175332.2 NR_029814 uc012cnp.1 uc012cnp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608644.1 [ECO:0000345] ##Evidence-Data-END## uc012cnp.1 uc012cnp.2 
ENSMUST00000175335.3 Mir3082 ENSMUST00000175335.3 microRNA 3082 (from RefSeq NR_037243.1) ENSMUST00000175335.1 ENSMUST00000175335.2 NR_037243 uc033hcb.1 uc033hcb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610893.1 [ECO:0000345] ##Evidence-Data-END## uc033hcb.1 uc033hcb.2 
ENSMUST00000175339.3 Mir3060 ENSMUST00000175339.3 microRNA 3060 (from RefSeq NR_037220.1) ENSMUST00000175339.1 ENSMUST00000175339.2 NR_037220 uc011xqu.1 uc011xqu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610870.1 [ECO:0000345] ##Evidence-Data-END## uc011xqu.1 uc011xqu.2 
ENSMUST00000175340.3 Mir3075 ENSMUST00000175340.3 microRNA 3075 (from RefSeq NR_037236.1) ENSMUST00000175340.1 ENSMUST00000175340.2 NR_037236 uc011zhn.1 uc011zhn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610886.1 [ECO:0000345] ##Evidence-Data-END## uc011zhn.1 uc011zhn.2 
ENSMUST00000175346.3 Mir3473d ENSMUST00000175346.3 microRNA 3473d (from RefSeq NR_039583.1) ENSMUST00000175346.1 ENSMUST00000175346.2 NR_039583 uc029wwb.1 uc029wwb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029wwb.1 uc029wwb.2 
ENSMUST00000175349.3 Mir3073a ENSMUST00000175349.3 microRNA 3073a (from RefSeq NR_037234.1) ENSMUST00000175349.1 ENSMUST00000175349.2 NR_037234 uc011yvc.1 uc011yvc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610884.1 [ECO:0000345] ##Evidence-Data-END## uc011yvc.1 uc011yvc.2 
ENSMUST00000175350.3 Mir3089 ENSMUST00000175350.3 microRNA 3089 (from RefSeq NR_037272.1) ENSMUST00000175350.1 ENSMUST00000175350.2 NR_037272 uc012btn.1 uc012btn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610930.1 [ECO:0000345] ##Evidence-Data-END## uc012btn.1 uc012btn.2 
ENSMUST00000175352.5 Gm22642 ENSMUST00000175352.5 Gm22642 (from geneSymbol) ENSMUST00000175352.1 ENSMUST00000175352.2 ENSMUST00000175352.3 ENSMUST00000175352.4 uc290gvu.1 uc290gvu.2 uc290gvu.1 uc290gvu.2 
ENSMUST00000175355.3 Mir3968 ENSMUST00000175355.3 microRNA 3968 (from RefSeq NR_039549.1) ENSMUST00000175355.1 ENSMUST00000175355.2 NR_039549 uc029rps.1 uc029rps.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029rps.1 uc029rps.2 
ENSMUST00000175356.3 Mir3097 ENSMUST00000175356.3 microRNA 3097 (from RefSeq NR_037280.1) ENSMUST00000175356.1 ENSMUST00000175356.2 NR_037280 uc012dva.1 uc012dva.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610937.1 [ECO:0000345] ##Evidence-Data-END## uc012dva.1 uc012dva.2 
ENSMUST00000175359.3 Mir3971 ENSMUST00000175359.3 microRNA 3971 (from RefSeq NR_039553.1) ENSMUST00000175359.1 ENSMUST00000175359.2 NR_039553 uc029rmr.1 uc029rmr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029rmr.1 uc029rmr.2 
ENSMUST00000175361.3 Mir3475 ENSMUST00000175361.3 microRNA 3475 (from RefSeq NR_037208.1) ENSMUST00000175361.1 ENSMUST00000175361.2 NR_037208 uc012hpm.1 uc012hpm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609658.1 [ECO:0000345] ##Evidence-Data-END## uc012hpm.1 uc012hpm.2 
ENSMUST00000175367.3 Mir344f ENSMUST00000175367.3 microRNA Mir344f (from RefSeq NR_037288.1) ENSMUST00000175367.1 ENSMUST00000175367.2 NR_037288 uc012fmk.1 uc012fmk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610945.1 [ECO:0000345] ##Evidence-Data-END## uc012fmk.1 uc012fmk.2 
ENSMUST00000175371.4 Gm22701 ENSMUST00000175371.4 Gm22701 (from geneSymbol) ENSMUST00000175371.1 ENSMUST00000175371.2 ENSMUST00000175371.3 uc292def.1 uc292def.2 uc292def.1 uc292def.2 
ENSMUST00000175376.3 Gm22699 ENSMUST00000175376.3 Gm22699 (from geneSymbol) ENSMUST00000175376.1 ENSMUST00000175376.2 uc288tie.1 uc288tie.2 uc288tie.1 uc288tie.2 
ENSMUST00000175377.3 Mir3083 ENSMUST00000175377.3 microRNA 3083 (from RefSeq NR_037244.1) ENSMUST00000175377.1 ENSMUST00000175377.2 NR_037244 uc012anu.1 uc012anu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610894.1 [ECO:0000345] ##Evidence-Data-END## uc012anu.1 uc012anu.2 
ENSMUST00000175379.3 Mir3474 ENSMUST00000175379.3 microRNA 3474 (from RefSeq NR_037312.1) ENSMUST00000175379.1 ENSMUST00000175379.2 NR_037312 uc012cik.1 uc012cik.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611144.1 [ECO:0000345] ##Evidence-Data-END## uc012cik.1 uc012cik.2 
ENSMUST00000175381.3 Mir1264 ENSMUST00000175381.3 microRNA 1264 (from RefSeq NR_037205.1) ENSMUST00000175381.1 ENSMUST00000175381.2 NR_037205 uc012hqb.1 uc012hqb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609649.1 [ECO:0000345] ##Evidence-Data-END## uc012hqb.1 uc012hqb.2 
ENSMUST00000175396.3 Gm25995 ENSMUST00000175396.3 Gm25995 (from geneSymbol) ENSMUST00000175396.1 ENSMUST00000175396.2 uc292iat.1 uc292iat.2 uc292iat.1 uc292iat.2 
ENSMUST00000175398.3 Gm25999 ENSMUST00000175398.3 Gm25999 (from geneSymbol) ENSMUST00000175398.1 ENSMUST00000175398.2 uc289bez.1 uc289bez.2 uc289bez.1 uc289bez.2 
ENSMUST00000175399.3 Mir28b ENSMUST00000175399.3 microRNA 28b (from RefSeq NR_039551.1) ENSMUST00000175399.1 ENSMUST00000175399.2 NR_039551 uc029wtw.1 uc029wtw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029wtw.1 uc029wtw.2 
ENSMUST00000175401.3 Mir3106 ENSMUST00000175401.3 microRNA 3106 (from RefSeq NR_037214.1) ENSMUST00000175401.1 ENSMUST00000175401.2 NR_037214 uc012gad.1 uc012gad.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609668.1 [ECO:0000345] ##Evidence-Data-END## uc012gad.1 uc012gad.2 
ENSMUST00000175406.3 Gm23369 ENSMUST00000175406.3 Gm23369 (from geneSymbol) DQ558729 ENSMUST00000175406.1 ENSMUST00000175406.2 uc289vdm.1 uc289vdm.2 uc289vdm.1 uc289vdm.2 
ENSMUST00000175415.3 Mir3076 ENSMUST00000175415.3 microRNA 3076 (from RefSeq NR_037237.1) ENSMUST00000175415.1 ENSMUST00000175415.2 NR_037237 uc029sia.1 uc029sia.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610887.1 [ECO:0000345] ##Evidence-Data-END## uc029sia.1 uc029sia.2 
ENSMUST00000175416.3 Mir3098 ENSMUST00000175416.3 microRNA 3098 (from RefSeq NR_037281.1) ENSMUST00000175416.1 ENSMUST00000175416.2 NR_037281 uc057aen.1 uc057aen.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057aen.1 uc057aen.2 
ENSMUST00000175426.3 Mir5131 ENSMUST00000175426.3 microRNA 5131 (from RefSeq NR_039593.1) ENSMUST00000175426.1 ENSMUST00000175426.2 NR_039593 uc029sip.1 uc029sip.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446434.1 [ECO:0000345] ##Evidence-Data-END## uc029sip.1 uc029sip.2 
ENSMUST00000175428.3 Mir3079 ENSMUST00000175428.3 microRNA 3079 (from RefSeq NR_037240.1) ENSMUST00000175428.1 ENSMUST00000175428.2 NR_037240 uc056yzd.1 uc056yzd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yzd.1 uc056yzd.2 
ENSMUST00000175431.3 Mir3112 ENSMUST00000175431.3 microRNA 3112 (from RefSeq NR_037299.1) ENSMUST00000175431.1 ENSMUST00000175431.2 NR_037299 uc012hoi.1 uc012hoi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610955.1 [ECO:0000345] ##Evidence-Data-END## uc012hoi.1 uc012hoi.2 
ENSMUST00000175435.3 Mir5119 ENSMUST00000175435.3 microRNA 5119 (from RefSeq NR_039579.1) ENSMUST00000175435.1 ENSMUST00000175435.2 NR_039579 uc029rnw.1 uc029rnw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446419.1 [ECO:0000345] ##Evidence-Data-END## uc029rnw.1 uc029rnw.2 
ENSMUST00000175437.3 Snord87 ENSMUST00000175437.3 small nucleolar RNA, C/D box 87 (from RefSeq NR_004410.1) ENSMUST00000175437.1 ENSMUST00000175437.2 NR_004410 uc011wif.1 uc011wif.2 uc011wif.3 uc011wif.1 uc011wif.2 uc011wif.3 
ENSMUST00000175442.5 Gm25687 ENSMUST00000175442.5 Gm25687 (from geneSymbol) AB350756 ENSMUST00000175442.1 ENSMUST00000175442.2 ENSMUST00000175442.3 ENSMUST00000175442.4 uc290muj.1 uc290muj.2 uc290muj.1 uc290muj.2 
ENSMUST00000175446.3 Mir344-2 ENSMUST00000175446.3 microRNA 344-2 (from RefSeq NR_030557.1) ENSMUST00000175446.1 ENSMUST00000175446.2 NR_030557 uc012fmi.1 uc012fmi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609922.1 [ECO:0000345] ##Evidence-Data-END## uc012fmi.1 uc012fmi.2 
ENSMUST00000175448.4 Gm25694 ENSMUST00000175448.4 Gm25694 (from geneSymbol) ENSMUST00000175448.1 ENSMUST00000175448.2 ENSMUST00000175448.3 uc287phl.1 uc287phl.2 uc287phl.1 uc287phl.2 
ENSMUST00000175450.5 Gm22876 ENSMUST00000175450.5 Gm22876 (from geneSymbol) ENSMUST00000175450.1 ENSMUST00000175450.2 ENSMUST00000175450.3 ENSMUST00000175450.4 uc288seh.1 uc288seh.2 uc288seh.1 uc288seh.2 
ENSMUST00000175461.4 Mir3547 ENSMUST00000175461.4 microRNA 3547 (from RefSeq NR_105931.1) ENSMUST00000175461.1 ENSMUST00000175461.2 ENSMUST00000175461.3 NR_105931 uc033hbs.1 uc033hbs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hbs.1 uc033hbs.2 
ENSMUST00000175468.4 Mir3070a ENSMUST00000175468.4 microRNA 3070a (from RefSeq NR_037230.1) ENSMUST00000175468.1 ENSMUST00000175468.2 ENSMUST00000175468.3 NR_037230 uc011ysi.1 uc011ysi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610880.1 [ECO:0000345] ##Evidence-Data-END## uc011ysi.1 uc011ysi.2 
ENSMUST00000175474.3 Mir3103 ENSMUST00000175474.3 microRNA 3103 (from RefSeq NR_037290.1) ENSMUST00000175474.1 ENSMUST00000175474.2 NR_037290 uc012fus.1 uc012fus.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610946.1 [ECO:0000345] ##Evidence-Data-END## uc012fus.1 uc012fus.2 
ENSMUST00000175478.3 Mir3113 ENSMUST00000175478.3 microRNA 3113 (from RefSeq NR_130340.1) ENSMUST00000175478.1 ENSMUST00000175478.2 NR_130340 uc057ate.1 uc057ate.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057ate.1 uc057ate.2 
ENSMUST00000175480.3 Mir3105 ENSMUST00000175480.3 microRNA 3105 (from RefSeq NR_037292.1) ENSMUST00000175480.1 ENSMUST00000175480.2 NR_037292 uc057akb.1 uc057akb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057akb.1 uc057akb.2 
ENSMUST00000175481.3 Gm25464 ENSMUST00000175481.3 Gm25464 (from geneSymbol) ENSMUST00000175481.1 ENSMUST00000175481.2 uc288wpb.1 uc288wpb.2 uc288wpb.1 uc288wpb.2 
ENSMUST00000175486.3 Mir1251 ENSMUST00000175486.3 microRNA 1251 (from RefSeq NR_037219.1) ENSMUST00000175486.1 ENSMUST00000175486.2 NR_037219 uc011xlo.1 uc011xlo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610869.1 [ECO:0000345] ##Evidence-Data-END## uc011xlo.1 uc011xlo.2 
ENSMUST00000175493.3 Mir3085 ENSMUST00000175493.3 microRNA 3085 (from RefSeq NR_037246.1) ENSMUST00000175493.1 ENSMUST00000175493.2 NR_037246 uc012blw.1 uc012blw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610896.1 [ECO:0000345] ##Evidence-Data-END## uc012blw.1 uc012blw.2 
ENSMUST00000175497.3 Mir9-3 ENSMUST00000175497.3 microRNA 9-3 (from RefSeq NR_029818.1) ENSMUST00000175497.1 ENSMUST00000175497.2 NR_029818 uc012fnh.1 uc012fnh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608648.1 [ECO:0000345] ##Evidence-Data-END## uc012fnh.1 uc012fnh.2 
ENSMUST00000175500.3 Mir3108 ENSMUST00000175500.3 microRNA 3108 (from RefSeq NR_037295.1) ENSMUST00000175500.1 ENSMUST00000175500.2 NR_037295 uc012gkg.1 uc012gkg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610951.1 [ECO:0000345] ##Evidence-Data-END## uc012gkg.1 uc012gkg.2 
ENSMUST00000175501.4 Gm24574 ENSMUST00000175501.4 Gm24574 (from geneSymbol) ENSMUST00000175501.1 ENSMUST00000175501.2 ENSMUST00000175501.3 uc289xci.1 uc289xci.2 uc289xci.1 uc289xci.2 
ENSMUST00000175505.3 Mir3618 ENSMUST00000175505.3 microRNA 3618 (from RefSeq NR_128565.1) ENSMUST00000175505.1 ENSMUST00000175505.2 NR_128565 uc056zbg.1 uc056zbg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zbg.1 uc056zbg.2 
ENSMUST00000175508.4 Gm24576 ENSMUST00000175508.4 Gm24576 (from geneSymbol) DQ559632 ENSMUST00000175508.1 ENSMUST00000175508.2 ENSMUST00000175508.3 uc291lyx.1 uc291lyx.2 uc291lyx.1 uc291lyx.2 
ENSMUST00000175513.3 Mir5126 ENSMUST00000175513.3 microRNA 5126 (from RefSeq NR_039588.1) ENSMUST00000175513.1 ENSMUST00000175513.2 NR_039588 uc029qpm.1 uc029qpm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446429.1, LM611530.1 [ECO:0000345] ##Evidence-Data-END## uc029qpm.1 uc029qpm.2 
ENSMUST00000175517.4 Gm22929 ENSMUST00000175517.4 Gm22929 (from geneSymbol) ENSMUST00000175517.1 ENSMUST00000175517.2 ENSMUST00000175517.3 uc290vzd.1 uc290vzd.2 uc290vzd.1 uc290vzd.2 
ENSMUST00000175528.3 Mir5124a ENSMUST00000175528.3 microRNA 5124a (from RefSeq NR_039585.1) ENSMUST00000175528.1 ENSMUST00000175528.2 NR_039585 uc057kpz.1 uc057kpz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057kpz.1 uc057kpz.2 
ENSMUST00000175529.3 Mir5134 ENSMUST00000175529.3 microRNA 5134 (from RefSeq NR_039596.1) ENSMUST00000175529.1 ENSMUST00000175529.2 NR_039596 uc029tbb.1 uc029tbb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446437.1, LM611536.1 [ECO:0000345] ##Evidence-Data-END## uc029tbb.1 uc029tbb.2 
ENSMUST00000175532.4 Mir3064 ENSMUST00000175532.4 microRNA 3064 (from RefSeq NR_037224.1) ENSMUST00000175532.1 ENSMUST00000175532.2 ENSMUST00000175532.3 NR_037224 uc011ygo.1 uc011ygo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610874.1 [ECO:0000345] ##Evidence-Data-END## uc011ygo.1 uc011ygo.2 
ENSMUST00000175536.3 Gm26236 ENSMUST00000175536.3 Gm26236 (from geneSymbol) ENSMUST00000175536.1 ENSMUST00000175536.2 uc289vee.1 uc289vee.2 uc289vee.1 uc289vee.2 
ENSMUST00000175537.3 Mir5110 ENSMUST00000175537.3 microRNA 5110 (from RefSeq NR_039570.1) ENSMUST00000175537.1 ENSMUST00000175537.2 NR_039570 uc056ynq.1 uc056ynq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056ynq.1 uc056ynq.2 
ENSMUST00000175539.3 Mir2861 ENSMUST00000175539.3 microRNA 2861 (from RefSeq NR_037217.1) ENSMUST00000175539.1 ENSMUST00000175539.2 NR_037217 uc012bty.1 uc012bty.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012bty.1 uc012bty.2 
ENSMUST00000175542.4 Gm22567 ENSMUST00000175542.4 Gm22567 (from geneSymbol) ENSMUST00000175542.1 ENSMUST00000175542.2 ENSMUST00000175542.3 uc289pjm.1 uc289pjm.2 uc289pjm.1 uc289pjm.2 
ENSMUST00000175548.3 Snord92 ENSMUST00000175548.3 small nucleolar RNA, C/D box 92 (from RefSeq NR_028556.2) ENSMUST00000175548.1 ENSMUST00000175548.2 NR_028556 uc012awv.1 uc012awv.2 uc012awv.3 uc012awv.4 uc012awv.1 uc012awv.2 uc012awv.3 uc012awv.4 
ENSMUST00000175549.3 Mir3572 ENSMUST00000175549.3 microRNA 3572 (from RefSeq NR_039587.1) ENSMUST00000175549.1 ENSMUST00000175549.2 NR_039587 uc029wdb.1 uc029wdb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446428.1, LM611529.1 [ECO:0000345] ##Evidence-Data-END## uc029wdb.1 uc029wdb.2 
ENSMUST00000175550.4 Mir299b ENSMUST00000175550.4 microRNA 299b (from RefSeq NR_049185.1) ENSMUST00000175550.1 ENSMUST00000175550.2 ENSMUST00000175550.3 NR_049185 uc029ryb.1 uc029ryb.2 uc029ryb.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029ryb.1 uc029ryb.2 uc029ryb.3 
ENSMUST00000175551.3 Mir5118 ENSMUST00000175551.3 microRNA 5118 (from RefSeq NR_039578.1) ENSMUST00000175551.1 ENSMUST00000175551.2 NR_039578 uc056zck.1 uc056zck.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zck.1 uc056zck.2 
ENSMUST00000175552.2 Mir3095 ENSMUST00000175552.2 microRNA 3095 (from RefSeq NR_037278.1) ENSMUST00000175552.1 NR_037278 uc012dev.1 uc012dev.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610936.1 [ECO:0000345] ##Evidence-Data-END## uc012dev.1 uc012dev.2 
ENSMUST00000175555.3 Mir3102 ENSMUST00000175555.3 microRNA 3102 (from RefSeq NR_037289.1) ENSMUST00000175555.1 ENSMUST00000175555.2 NR_037289 uc012fqh.1 uc012fqh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012fqh.1 uc012fqh.2 
ENSMUST00000175557.3 Mir3473b ENSMUST00000175557.3 microRNA 3473b (from RefSeq NR_039554.1) ENSMUST00000175557.1 ENSMUST00000175557.2 NR_039554 uc057kio.1 uc057kio.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057kio.1 uc057kio.2 
ENSMUST00000175570.3 Mir3965 ENSMUST00000175570.3 microRNA 3965 (from RefSeq NR_039544.1) ENSMUST00000175570.1 ENSMUST00000175570.2 NR_039544 uc057abt.1 uc057abt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057abt.1 uc057abt.2 
ENSMUST00000175573.3 Mir5136 ENSMUST00000175573.3 microRNA 5136 (from RefSeq NR_039598.1) ENSMUST00000175573.1 ENSMUST00000175573.2 NR_039598 uc289quf.1 uc289quf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446439.1 [ECO:0000345] ##Evidence-Data-END## uc289quf.1 uc289quf.2 
ENSMUST00000175574.3 Mir5114 ENSMUST00000175574.3 microRNA 5114 (from RefSeq NR_039574.1) ENSMUST00000175574.1 ENSMUST00000175574.2 NR_039574 uc029tsk.1 uc029tsk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446414.1, LM611522.1 [ECO:0000345] ##Evidence-Data-END## uc029tsk.1 uc029tsk.2 
ENSMUST00000175580.3 Snord93 ENSMUST00000175580.3 small nucleolar RNA, C/D box 93 (from RefSeq NR_028536.1) ENSMUST00000175580.1 ENSMUST00000175580.2 NR_028536 uc012dsy.1 uc012dsy.2 uc012dsy.3 uc012dsy.4 uc012dsy.5 uc012dsy.1 uc012dsy.2 uc012dsy.3 uc012dsy.4 uc012dsy.5 
ENSMUST00000175584.3 Gm26061 ENSMUST00000175584.3 Gm26061 (from geneSymbol) ENSMUST00000175584.1 ENSMUST00000175584.2 uc287xzz.1 uc287xzz.2 uc287xzz.1 uc287xzz.2 
ENSMUST00000175586.3 Mir5107 ENSMUST00000175586.3 microRNA 5107 (from RefSeq NR_039567.1) ENSMUST00000175586.1 ENSMUST00000175586.2 NR_039567 uc029tnb.1 uc029tnb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446407.1, LM611519.1 [ECO:0000345] ##Evidence-Data-END## uc029tnb.1 uc029tnb.2 
ENSMUST00000175595.3 Mir1954 ENSMUST00000175595.3 microRNA 1954 (from RefSeq NR_035479.1) ENSMUST00000175595.1 ENSMUST00000175595.2 NR_035479 uc056zlz.1 uc056zlz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zlz.1 uc056zlz.2 
ENSMUST00000175597.3 Mir3090 ENSMUST00000175597.3 microRNA 3090 (from RefSeq NR_037273.1) ENSMUST00000175597.1 ENSMUST00000175597.2 NR_037273 uc056zps.1 uc056zps.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zps.1 uc056zps.2 
ENSMUST00000175604.5 Gm27956 ENSMUST00000175604.5 Gm27956 (from geneSymbol) ENSMUST00000175604.1 ENSMUST00000175604.2 ENSMUST00000175604.3 ENSMUST00000175604.4 uc292cyl.1 uc292cyl.2 uc292cyl.1 uc292cyl.2 
ENSMUST00000175607.3 Mir3101 ENSMUST00000175607.3 microRNA 3101 (from RefSeq NR_037283.1) ENSMUST00000175607.1 ENSMUST00000175607.2 NR_037283 uc012fgg.1 uc012fgg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610940.1 [ECO:0000345] ##Evidence-Data-END## uc012fgg.1 uc012fgg.2 
ENSMUST00000175610.3 Mir3072 ENSMUST00000175610.3 microRNA 3072 (from RefSeq NR_037233.1) ENSMUST00000175610.1 ENSMUST00000175610.2 NR_037233 uc011yul.1 uc011yul.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610883.1 [ECO:0000345] ##Evidence-Data-END## uc011yul.1 uc011yul.2 
ENSMUST00000175612.4 Mir344h-2 ENSMUST00000175612.4 microRNA 344h-2 (from RefSeq NR_049202.1) ENSMUST00000175612.1 ENSMUST00000175612.2 ENSMUST00000175612.3 NR_049202 uc033izx.1 uc033izx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033izx.1 uc033izx.2 
ENSMUST00000175613.3 Mir125b-1 ENSMUST00000175613.3 microRNA 125b-1 (from RefSeq NR_029822.1) ENSMUST00000175613.1 ENSMUST00000175613.2 NR_029822 uc009pam.1 uc009pam.2 uc009pam.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608652.1 [ECO:0000345] ##Evidence-Data-END## uc009pam.1 uc009pam.2 uc009pam.3 
ENSMUST00000175614.3 Snora26 ENSMUST00000175614.3 small nucleolar RNA, H/ACA box 26 (from RefSeq NR_031758.1) ENSMUST00000175614.1 ENSMUST00000175614.2 NR_031758 uc012dxg.1 uc012dxg.2 uc012dxg.1 uc012dxg.2 
ENSMUST00000175617.3 Mir3063 ENSMUST00000175617.3 microRNA 3063 (from RefSeq NR_037223.1) ENSMUST00000175617.1 ENSMUST00000175617.2 NR_037223 uc029rns.1 uc029rns.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610873.1 [ECO:0000345] ##Evidence-Data-END## uc029rns.1 uc029rns.2 
ENSMUST00000175637.3 Or1f12 ENSMUST00000175637.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQT9) A0A0U1RPS8 E9PY00 ENSMUST00000175637.1 ENSMUST00000175637.2 H3BKM1 Olfr1366 Or1f12 Q7TQT9 Q7TQT9_MOUSE uc288lfd.1 uc288lfd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288lfd.1 uc288lfd.2 
ENSMUST00000175639.3 Mir1231 ENSMUST00000175639.3 microRNA 1231 (from RefSeq NR_049188.1) ENSMUST00000175639.1 ENSMUST00000175639.2 NR_049188 uc033flm.1 uc033flm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611585.1 [ECO:0000345] ##Evidence-Data-END## uc033flm.1 uc033flm.2 
ENSMUST00000175646.2 Agps ENSMUST00000175646.2 Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids. (from UniProt H3BKN2) AK031154 Agps ENSMUST00000175646.1 H3BKN2 H3BKN2_MOUSE uc289xct.1 uc289xct.2 Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids. Reaction=a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+); Xref=Rhea:RHEA:36171, ChEBI:CHEBI:15378, ChEBI:CHEBI:17135, ChEBI:CHEBI:57534, ChEBI:CHEBI:57560, ChEBI:CHEBI:73315; EC=2.5.1.26; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Glycerolipid metabolism; ether lipid biosynthesis. Homodimer. Peroxisome Belongs to the FAD-binding oxidoreductase/transferase type 4 family. catalytic activity peroxisome lipid metabolic process alkylglycerone-phosphate synthase activity lipid biosynthetic process ether lipid biosynthetic process oxidoreductase activity transferase activity flavin adenine dinucleotide binding oxidation-reduction process FAD binding uc289xct.1 uc289xct.2 
ENSMUST00000175674.2 Gm20667 ENSMUST00000175674.2 Gm20667 (from geneSymbol) ENSMUST00000175674.1 LF200044 uc288vic.1 uc288vic.2 uc288vic.1 uc288vic.2 
ENSMUST00000175681.3 Kcnb2 ENSMUST00000175681.3 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. (from UniProt A6H8H5) A6H8H5 BC146609 E9Q5T7 ENSMUST00000175681.1 ENSMUST00000175681.2 KCNB2_MOUSE Kcnb2 uc287gpo.1 uc287gpo.2 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Inhibited by quinine at micromolar levels. Modestly sensitive to millimolar levels of tetraethylammonium (TEA) and 4-aminopyridine (4-AP). Kinetic parameters: Note=Homotetrameric channels expressed in xenopus oocytes or in mammalian non-neuronal cells display delayed-rectifier voltage- dependent potassium currents which are activated during membrane depolarization, i.e within a risetime of about 20 msec. After that, inactivate very slowly. Their activation requires low threshold potentials of about -20 to -30 mV, with a midpoint activation at about 10 mV. For inactivation, the voltage at half-maximal amplitude is about -30 mV. Channels have an unitary conductance of about 14 pS. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system and post-translational modifications. ; Homotetramer or heterotetramer with KCNB1. Heterotetramer with KCNS1 and KCNS2. Interacts (via phosphorylated FFAT motif) with VAPA and VAPB. Cell membrane ; Multi-pass membrane protein Perikaryon Cell projection, dendrite Note=Localized uniformly throughout cell bodies and dendrites. Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons. The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. Phosphorylated (By similarity). Phosphorylation at Ser-608 of the FFAT motif activates interaction with MOSPD2, VAPA and VAPB (By similarity). Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane dendrite neuronal cell body membrane regulation of ion transmembrane transport cell projection neuronal cell body perikaryon ion channel binding protein heterodimerization activity protein homooligomerization transmembrane transport potassium ion transmembrane transport protein localization to plasma membrane uc287gpo.1 uc287gpo.2 
ENSMUST00000175690.2 Gm20650 ENSMUST00000175690.2 Gm20650 (from geneSymbol) ENSMUST00000175690.1 uc291vqj.1 uc291vqj.2 uc291vqj.1 uc291vqj.2 
ENSMUST00000175714.8 Apobec3 ENSMUST00000175714.8 DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. Selectively targets single- stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against HIV-1, simian immunodeficiency viruses (SIVs), mouse mammary tumor virus (MMTV) and friend murine leukemia virus (FrMLV) and may inhibit the mobility of LTR retrotransposons. (from UniProt Q99J72) ABEC3_MOUSE BC003314 ENSMUST00000175714.1 ENSMUST00000175714.2 ENSMUST00000175714.3 ENSMUST00000175714.4 ENSMUST00000175714.5 ENSMUST00000175714.6 ENSMUST00000175714.7 H3BJL0 Q8C7L0 Q8C8V7 Q99J72 uc288zsm.1 uc288zsm.2 DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. Selectively targets single- stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against HIV-1, simian immunodeficiency viruses (SIVs), mouse mammary tumor virus (MMTV) and friend murine leukemia virus (FrMLV) and may inhibit the mobility of LTR retrotransposons. Reaction=a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O = a 2'- deoxyuridine in single-stranded DNA + NH4(+); Xref=Rhea:RHEA:50948, Rhea:RHEA-COMP:12846, Rhea:RHEA-COMP:12847, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:85452, ChEBI:CHEBI:133902; EC=3.5.4.38; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Homodimer. Interacts with mouse mammary tumor virus (MMTV) nucleocapsid protein p14. Cytoplasm Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q99J72-1; Sequence=Displayed; Name=2; IsoId=Q99J72-2; Sequence=VSP_009832; Name=3; IsoId=Q99J72-3; Sequence=VSP_009831, VSP_009833; Name=4; IsoId=Q99J72-4; Sequence=VSP_009831; Expressed in spleen, node and lung. The CMP/dCMP deaminase domain 1 confers deoxycytidine deaminase activity, whereas the CMP/dCMP deaminase domain 2 mediates RNA- dependent oligomerization and virion incorporation. Probable human APOBEC3G ortholog. [Isoform 4]: Lacks exon V. Found in cell line MDTF. Belongs to the cytidine and deoxycytidylate deaminase family. Sequence=AAH03314.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC31901.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC34023.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; P-body hematopoietic progenitor cell differentiation immune system process RNA binding catalytic activity cytidine deaminase activity protein binding nucleus cytoplasm zinc ion binding cytidine deamination negative regulation of transposition cytidine to uridine editing hydrolase activity negative regulation of viral genome replication innate immune response negative regulation of single stranded viral RNA replication via double stranded DNA intermediate metal ion binding deoxycytidine deaminase activity regulation of defense response to virus defense response to virus DNA cytosine deamination DNA demethylation regulation of viral life cycle uc288zsm.1 uc288zsm.2 
ENSMUST00000175723.2 Gm19553 ENSMUST00000175723.2 Gm19553 (from geneSymbol) ENSMUST00000175723.1 uc289knu.1 uc289knu.2 uc289knu.1 uc289knu.2 
ENSMUST00000175724.9 Vmn2r4 ENSMUST00000175724.9 vomeronasal 2, receptor 4 (from RefSeq NM_001385080.1) ENSMUST00000175724.1 ENSMUST00000175724.2 ENSMUST00000175724.3 ENSMUST00000175724.4 ENSMUST00000175724.5 ENSMUST00000175724.6 ENSMUST00000175724.7 ENSMUST00000175724.8 K7N784 K7N784_MOUSE NM_001385080 Vmn2r4 uc290frb.1 uc290frb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc290frb.1 uc290frb.2 
ENSMUST00000175746.3 Gm23187 ENSMUST00000175746.3 Gm23187 (from geneSymbol) ENSMUST00000175746.1 ENSMUST00000175746.2 uc290alo.1 uc290alo.2 uc290alo.1 uc290alo.2 
ENSMUST00000175765.8 Tirap ENSMUST00000175765.8 toll-interleukin 1 receptor (TIR) domain-containing adaptor protein, transcript variant 1 (from RefSeq NM_001177845.1) ENSMUST00000175765.1 ENSMUST00000175765.2 ENSMUST00000175765.3 ENSMUST00000175765.4 ENSMUST00000175765.5 ENSMUST00000175765.6 ENSMUST00000175765.7 H3BKL1 H3BKL1_MOUSE NM_001177845 Tirap uc012gqe.1 uc012gqe.2 uc012gqe.3 Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response. Homodimer. Cytoplasm Cell membrane Membrane protein kinase C binding cytoplasm plasma membrane signal transduction activation of NF-kappaB-inducing kinase activity response to lipopolysaccharide positive regulation of interleukin-15 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of toll-like receptor 2 signaling pathway positive regulation of toll-like receptor 4 signaling pathway Toll-like receptor 4 binding Toll-like receptor 2 binding TIRAP-dependent toll-like receptor 4 signaling pathway identical protein binding positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of interleukin-6 biosynthetic process positive regulation of JNK cascade protein heterodimerization activity positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade 3'-UTR-mediated mRNA stabilization positive regulation of protein homodimerization activity uc012gqe.1 uc012gqe.2 uc012gqe.3 
ENSMUST00000175795.4 Irx3 ENSMUST00000175795.4 Iroquois related homeobox 3, transcript variant 2 (from RefSeq NM_008393.3) ENSMUST00000175795.1 ENSMUST00000175795.2 ENSMUST00000175795.3 IRX3_MOUSE Irxb1 NM_008393 P81067 Q3UPZ3 Q5U3K8 uc009msu.1 uc009msu.2 uc009msu.3 uc009msu.4 Transcription factor involved in SHH-dependent neural patterning (PubMed:10830170, PubMed:15201216). Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube (PubMed:10830170, PubMed:15201216). Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals (PubMed:10830170, PubMed:15201216). Involved in the transcriptional repression of MNX1 in non-motor neuron cells (PubMed:15201216). Acts as a regulator of energy metabolism (PubMed:24646999). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P81067-1; Sequence=Displayed; Name=2; IsoId=P81067-2; Sequence=VSP_038351; Expressed by neural progenitor cells in discrete domains of the ventral neural tube. Also expressed in specific and overlapping patterns with Irx1 and Irx2 in the developing and adult metanephric kidney. In the adult metanephros, renal expression is confined to the S3 segment of the proximal tubule, in the loop of Henle. The earliest expressed of the Irx family, with expression seen in trophectoderm-derived extraembryonic tissues from 6.5 dpc, including expression in the chorionic ectoderm at 8.0 dpc. Embryonic expression starts at the end of gastrulation (7.5 dpc) in the ectodermal layer which gives rise to the nervous system. At 8.0 dpc, expression is confined to the thickening neural ectoderm corresponding to the future mesencephalon (midbrain) and rhombencephalon (hindbrain) and from 8.5 dpc onwards, expression also includes the rostral part of the closing neural tube. After neural tube closure at 9.5 dpc, expression predominates in the CNS in the midbrain, hindbrain and spinal cord. Also expressed in a number of tissues outside of the CNS including ectodermal layer of the branchial arches. Expressed in the prospective limb buds of the lateral plate mesoderm, and from 10.5 dpc onwards a gradient exists along the dorsoventral and proximodistal axes of developing limbs. Expressed in the notochord at stage 9.0 dpc. At 9.5 dpc found in the cephalic mesoderm surrounding the optic vesicle. Around 10.5 dpc, expression in the head mesoderm extends into the nasal pits. By 12.5 dpc, still expressed in the mesenchyme, and expressions begins in specific subsets of post-mitotic cells in the neuroretina. As development ensues, expression increases in the neuroretina and mesenchymal expression gradually decreases. At 16.5 dpc, expressed exclusively in the inner neuroblast layers of the neuroretina. In the developing heart, first expressed in the trabecules of embryonic ventricles at 9.5 dpc, and from then onwards localizes specifically to the trabeculated myocardium of the ventricles. Mice are viable and fertile but display a significant reduction of body weight, primarily through the loss of fat mass and increase in basal metabolic rate with browning of white adipose tissue. Belongs to the TALE/IRO homeobox family. Sequence=CAA75233.1; Type=Frameshift; Evidence=; metanephros development kidney development DNA binding nucleus cytoplasm regulation of transcription, DNA-templated multicellular organism development mesoderm development axon sequence-specific DNA binding negative regulation of neuron differentiation positive regulation of neuron differentiation proximal/distal pattern formation involved in nephron development specification of loop of Henle identity energy homeostasis uc009msu.1 uc009msu.2 uc009msu.3 uc009msu.4 
ENSMUST00000175796.2 Gm20638 ENSMUST00000175796.2 Gm20638 (from geneSymbol) ENSMUST00000175796.1 uc289zcy.1 uc289zcy.2 uc289zcy.1 uc289zcy.2 
ENSMUST00000175817.2 Vmn1r23 ENSMUST00000175817.2 vomeronasal 1 receptor 23 (from RefSeq NM_134179.1) ENSMUST00000175817.1 NM_134179 Q8R2D0 Q8R2D0_MOUSE V1rc24 Vmn1r23 uc009ccs.1 uc009ccs.2 uc009ccs.3 Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009ccs.1 uc009ccs.2 uc009ccs.3 
ENSMUST00000175846.3 Gm20686 ENSMUST00000175846.3 Gm20686 (from geneSymbol) ENSMUST00000175846.1 ENSMUST00000175846.2 uc292dcg.1 uc292dcg.2 uc292dcg.3 uc292dcg.1 uc292dcg.2 uc292dcg.3 
ENSMUST00000175853.3 Vmn2r130 ENSMUST00000175853.3 vomeronasal 2, receptor 130 (from RefSeq NM_001384262.1) A0A140T8U3 A0A140T8U3_MOUSE ENSMUST00000175853.1 ENSMUST00000175853.2 NM_001384262 Vmn2r130 uc289hrp.1 uc289hrp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc289hrp.1 uc289hrp.2 
ENSMUST00000175854.4 4930505M18Rik ENSMUST00000175854.4 RIKEN cDNA 4930505M18 gene (from RefSeq NR_166497.1) ENSMUST00000175854.1 ENSMUST00000175854.2 ENSMUST00000175854.3 NR_166497 uc009gkn.1 uc009gkn.2 uc009gkn.3 uc009gkn.4 uc009gkn.1 uc009gkn.2 uc009gkn.3 uc009gkn.4 
ENSMUST00000175866.8 Zfhx4 ENSMUST00000175866.8 zinc finger homeodomain 4, transcript variant 1 (from RefSeq NM_001368671.1) ENSMUST00000175866.1 ENSMUST00000175866.2 ENSMUST00000175866.3 ENSMUST00000175866.4 ENSMUST00000175866.5 ENSMUST00000175866.6 ENSMUST00000175866.7 H3BLK8 H3BLK8_MOUSE NM_001368671 Zfhx4 uc290dso.1 uc290dso.2 Nucleus nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated zinc ion binding sequence-specific DNA binding metal ion binding uc290dso.1 uc290dso.2 
ENSMUST00000175883.8 Ryk ENSMUST00000175883.8 receptor-like tyrosine kinase, transcript variant 1 (from RefSeq NM_013649.3) ENSMUST00000175883.1 ENSMUST00000175883.2 ENSMUST00000175883.3 ENSMUST00000175883.4 ENSMUST00000175883.5 ENSMUST00000175883.6 ENSMUST00000175883.7 Mrk NM_013649 Q01887 Q61890 RYK_MOUSE uc009rga.1 uc009rga.2 uc009rga.3 May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Interacts with DVL1 (via PDZ domain). Q01887; P35222: CTNNB1; Xeno; NbExp=2; IntAct=EBI-16110594, EBI-491549; Membrane ; Single- pass type I membrane protein Nucleus Cytoplasm Note=In cells that have undergone neuronal differentiation, the C- terminal cleaved part is translocated from the cytoplasm to the nucleus. Is detected in all the tissues. Highest levels are seen in the ovary, lung and placenta. Highest expression at 16 dpc when callosal axons are beginning to cross the midline. At 17 dpc-18 dpc, when the majority of axons are projecting away from the midline, expression is observed but at a lower level. Present on the cell bodies of neurons in cortical layers at 18 dpc. The extracellular WIF domain is responsible for Wnt binding. Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Sequence=AAA40079.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAA40079.1; Type=Frameshift; Evidence=; nucleotide binding protein kinase activity transmembrane signaling receptor activity frizzled binding protein binding ATP binding nucleus cytoplasm plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway nervous system development axonogenesis axon guidance membrane integral component of membrane Wnt signaling pathway kinase activity phosphorylation transferase activity Wnt-protein binding peptidyl-tyrosine phosphorylation corpus callosum development neuron differentiation neuron projection development chemorepulsion of dopaminergic neuron axon Wnt-activated receptor activity receptor complex positive regulation of MAPK cascade skeletal system morphogenesis negative regulation of axon extension involved in axon guidance negative chemotaxis chemorepulsion of axon commissural neuron axon guidance planar cell polarity pathway involved in axon guidance midbrain dopaminergic neuron differentiation Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity uc009rga.1 uc009rga.2 uc009rga.3 
ENSMUST00000175898.4 Six3 ENSMUST00000175898.4 Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon (PubMed:18094027). Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression (PubMed:18775421). In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration (PubMed:22071110). Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2 (PubMed:17576749). During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm (PubMed:17066077). In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation (PubMed:12072567). Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory (PubMed:20890044). Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element (PubMed:11139622). Directly activates RHO transcription, or cooperates with CRX or NRL (PubMed:17666527). Six3 functions also in the formation of the proximodistal axis of the optic cup (PubMed:12163408), and promotes the formation of optic vesicles-like structures (PubMed:11458394). During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (PubMed:18694563). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway (By similarity). (from UniProt Q62233) ENSMUST00000175898.1 ENSMUST00000175898.2 ENSMUST00000175898.3 P70176 P70177 Q4QQQ3 Q62233 SIX3_MOUSE X90871 uc289ngu.1 uc289ngu.2 Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon (PubMed:18094027). Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression (PubMed:18775421). In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration (PubMed:22071110). Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2 (PubMed:17576749). During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm (PubMed:17066077). In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation (PubMed:12072567). Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory (PubMed:20890044). Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element (PubMed:11139622). Directly activates RHO transcription, or cooperates with CRX or NRL (PubMed:17666527). Six3 functions also in the formation of the proximodistal axis of the optic cup (PubMed:12163408), and promotes the formation of optic vesicles-like structures (PubMed:11458394). During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (PubMed:18694563). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway (By similarity). Interacts with EYA4; translocates EYA4 from the cytoplasm to the nucleus and promotes activation of their target genes. Interacts with MTA1 and HDAC2; represses its own transcription. Interacts with MTA1; facilitates the binding of SIX3 to the core DNA motif of SIX3 promoter. Interacts with EYA1; promotes EYA1 translocation to the nucleus. Interacts with TLE1 and TLE5 (via Q domain); can act in combination with either TLE1 and/or TLE5 leading to transcriptional repression or activation, respectively (By similarity). Interacts (via homeobox) with NR4A3; differentially regulates the transcriptional activities NR4A3 (By similarity). Interacts with GMNN (By similarity). Interacts with TLE4. Q62233; P70288: Hdac2; NbExp=2; IntAct=EBI-2297327, EBI-302251; Q62233; Q8K4B0: Mta1; NbExp=2; IntAct=EBI-2297327, EBI-1216353; Q62233; Q62441: Tle4; NbExp=2; IntAct=EBI-2297327, EBI-2297871; Q62233; P63002: Tle5; NbExp=5; IntAct=EBI-2297327, EBI-646888; Q62233; P16371: gro; Xeno; NbExp=2; IntAct=EBI-2297327, EBI-153866; Nucleus Event=Alternative splicing; Named isoforms=2; Name=SIX3B ; IsoId=Q62233-1; Sequence=Displayed; Name=SIX3A ; IsoId=Q62233-2; Sequence=VSP_002291, VSP_002292; Expressed in ependymal cells during the formation of the lateral wall. Expressed in the developing retina (at protein level). First expressed at 6.5 dpc of embryo development around the anterior border. At 8.5 dpc, expression is found over the anterior neural plate. At 9.5 dpc, in the diencephalic part of the ventral forebrain, optic vesicles, olfactory placodes and Rathke pouch. In later stages, present in hypothalamus, eyes and pituitary. Expression at around 7.5 dpc to 8 dpc is high in the anterior neural ectoderm. Weaker expression is detected in the prechordal plate. At the 5 somite stage (8.0 dpc), expression is maintained in the anterior neural ectoderm. Around the 8 somite stage (8.0 dpc), expression is already restricted to the ventral forebrain and eye field. At the 12 somite stage (8.5 dpc), expression is maintained in the ventral forebrain (PubMed:18694563). At 9.5 dpc strongly expressed throughout the prospective nasal ectoderm. At 10.5 dpc remains expressed throughout the nasal ectoderm (PubMed:16024294). At 7.5 dpc expression is found in the developing anterior neuroectoderm. At 9.0 dpc expression is found in the region of the presumptive lens ectoderm and developing optic vesicle. At 9.5 dpc expression is found in the lens placode, optic vesicles, and ventral forebrain (PubMed:11458394). Represses its own transcription in a TLE4-dependent manner. Induces in lens by PAX6 in a dosage-dependent manner. Activated by SOX2 during forebrain development. Inhibited by MTA1 in mammary glands. Embryos die at birth and lack most head structures anterior to the midbrain, including the eyes and nose (PubMed:12569128). Embryonic SHH and SIX3 double heterozygous mice exhibit a semilobar holoprosencephaly-like phenotype and a dorsoventral patterning defects in telencephalon (PubMed:18694563). Embryonic WNT1 and SIX3 double homozygous mice lack cerebellum and colliculus and have a severely reduced midbrain (PubMed:18094027). Conditional knockout in eye exhibit drastically reduced lens size, cataracts, or absence of the lens (PubMed:17066077). Embryo of SIX3 and HESX1 heterozygous mice exhibit severe growth retardation after weaning, with additional gonadal and thyroid gland defects, resulting in a lethal phenotype (PubMed:18775421). Belongs to the SIX/Sine oculis homeobox family. Sequence=CAA62379.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAA62379.1; Type=Frameshift; Evidence=; transcription regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription corepressor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding eye development epithelial cell maturation lens development in camera-type eye optic vesicle morphogenesis DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity receptor binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated protein import into nucleus multicellular organism development brain development proximal/distal axis specification neuroblast differentiation diencephalon development telencephalon development forebrain anterior/posterior pattern specification forebrain dorsal/ventral pattern formation cell proliferation in forebrain telencephalon regionalization pituitary gland development negative regulation of Wnt signaling pathway regulation of cell proliferation histone deacetylase binding camera-type eye development sequence-specific DNA binding negative regulation of neuron differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter circadian behavior anatomical structure development lens induction in camera-type eye regulation of neural retina development lens fiber cell differentiation neuroblast migration regulation of cell cycle phase transition regulation of neuroblast proliferation apoptotic process involved in development lens fiber cell apoptotic process regulation of neural precursor cell proliferation uc289ngu.1 uc289ngu.2 
ENSMUST00000175907.3 Mir5618 ENSMUST00000175907.3 microRNA 5618 (from RefSeq NR_049191.1) ENSMUST00000175907.1 ENSMUST00000175907.2 NR_049191 uc033jio.1 uc033jio.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jio.1 uc033jio.2 
ENSMUST00000175916.8 Prox1 ENSMUST00000175916.8 prospero homeobox 1, transcript variant 1 (from RefSeq NM_008937.3) ENSMUST00000175916.1 ENSMUST00000175916.2 ENSMUST00000175916.3 ENSMUST00000175916.4 ENSMUST00000175916.5 ENSMUST00000175916.6 ENSMUST00000175916.7 NM_008937 O88478 P48437 PROX1_MOUSE Q3UPV1 Q543D8 uc033fol.1 uc033fol.2 uc033fol.3 uc033fol.4 Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. Interacts with RORA and RORG (via AF-2 motif). Nucleus Note=RORG promotes its nuclear localization. Expressed in the young neurons of the subventricular region of the CNS, developing eye lens and pancreas. It is also found in the developing liver, heart and skeletal muscle. In the eye, expressed in the lens and retina at postnatal day 10. In the retina, localized to the inner nuclear layer. In the lens, localized to epithelial and fiber cells. Expressed in mesenteric lymphatic endothelial cells at 16.5 dpc, expression is reduced after this point apart from in the lymphatic valve region where expression remains strong at 18.5 dpc (at protein level). Expressed in a circadian manner in the liver with a peak at ZT4. The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain (Potential). The Prospero-type homeodomain is essential for repression of RORG transcriptional activator activity (PubMed:23723244). Belongs to the Prospero homeodomain family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding cell fate determination kidney development liver development positive regulation of endothelial cell proliferation lymph vessel development lymphangiogenesis lens development in camera-type eye lens morphogenesis in camera-type eye hepatocyte cell migration DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated multicellular organism development brain development circadian rhythm positive regulation of cell proliferation negative regulation of cell proliferation regulation of gene expression positive regulation of endothelial cell migration ligand-dependent nuclear receptor binding dentate gyrus development cerebellar granule cell differentiation skeletal muscle thin filament assembly lung development pancreas development response to nutrient levels regulation of circadian rhythm negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of viral genome replication endothelial cell differentiation positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter optic placode formation involved in camera-type eye formation rhythmic process inner ear development venous blood vessel morphogenesis DBD domain binding LBD domain binding ventricular cardiac myofibril assembly atrial cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue morphogenesis embryonic retina morphogenesis in camera-type eye endocardium formation positive regulation of sarcomere organization ventricular septum morphogenesis aorta smooth muscle tissue morphogenesis positive regulation of heart growth lymphatic endothelial cell differentiation regulation of transcription involved in lymphatic endothelial cell fate commitment branching involved in pancreas morphogenesis lens fiber cell morphogenesis hepatocyte differentiation negative regulation of bile acid biosynthetic process hepatocyte proliferation acinar cell differentiation neuronal stem cell population maintenance positive regulation of cell cycle checkpoint positive regulation of neural precursor cell proliferation positive regulation of forebrain neuron differentiation uc033fol.1 uc033fol.2 uc033fol.3 uc033fol.4 
ENSMUST00000175928.3 Mir5622 ENSMUST00000175928.3 microRNA 5622 (from RefSeq NR_049195.1) ENSMUST00000175928.1 ENSMUST00000175928.2 NR_049195 uc033hqw.1 uc033hqw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hqw.1 uc033hqw.2 
ENSMUST00000175934.8 Tcof1 ENSMUST00000175934.8 treacle ribosome biogenesis factor 1, transcript variant 1 (from RefSeq NM_001198984.1) ENSMUST00000175934.1 ENSMUST00000175934.2 ENSMUST00000175934.3 ENSMUST00000175934.4 ENSMUST00000175934.5 ENSMUST00000175934.6 ENSMUST00000175934.7 H3BL37 H3BL37_MOUSE NM_001198984 Tcof1 uc008fbc.1 uc008fbc.2 uc008fbc.3 uc008fbc.4 uc008fbc.5 RNA polymerase I core binding fibrillar center nucleus nucleolus cytosol regulation of translation neural crest formation neural crest cell development protein heterodimerization activity scaffold protein binding uc008fbc.1 uc008fbc.2 uc008fbc.3 uc008fbc.4 uc008fbc.5 
ENSMUST00000175942.8 A230072E10Rik ENSMUST00000175942.8 A230072E10Rik (from geneSymbol) AK038885 ENSMUST00000175942.1 ENSMUST00000175942.2 ENSMUST00000175942.3 ENSMUST00000175942.4 ENSMUST00000175942.5 ENSMUST00000175942.6 ENSMUST00000175942.7 uc009uoz.1 uc009uoz.2 uc009uoz.1 uc009uoz.2 
ENSMUST00000175955.4 Pou5f2 ENSMUST00000175955.4 POU domain class 5, transcription factor 2 (from RefSeq NM_029315.1) A0A0R4J273 A0A0R4J273_MOUSE ENSMUST00000175955.1 ENSMUST00000175955.2 ENSMUST00000175955.3 NM_029315 Pou5f2 uc011zcd.1 uc011zcd.2 uc011zcd.3 Nucleus Belongs to the POU transcription factor family. DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated uc011zcd.1 uc011zcd.2 uc011zcd.3 
ENSMUST00000175965.10 Onecut2 ENSMUST00000175965.10 one cut domain, family member 2 (from RefSeq NM_194268.3) ENSMUST00000175965.1 ENSMUST00000175965.2 ENSMUST00000175965.3 ENSMUST00000175965.4 ENSMUST00000175965.5 ENSMUST00000175965.6 ENSMUST00000175965.7 ENSMUST00000175965.8 ENSMUST00000175965.9 NM_194268 ONEC2_MOUSE Oc2 Q6XBJ3 uc289piz.1 uc289piz.2 uc289piz.3 Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B (By similarity). Nucleus. Belongs to the CUT homeobox family. It is uncertain whether Met-1 or Met-20 is the initiator. Sequence=AAP69907.1; Type=Erroneous initiation; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding liver development regulation of cell-matrix adhesion epithelial cell development DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm anatomical structure morphogenesis actin cytoskeleton cell differentiation positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway pancreas development endocrine pancreas development cell fate commitment positive regulation of transcription from RNA polymerase II promoter peripheral nervous system neuron development cilium assembly uc289piz.1 uc289piz.2 uc289piz.3 
ENSMUST00000175971.3 Vmn2r128 ENSMUST00000175971.3 Vmn2r128 (from geneSymbol) ENSMUST00000175971.1 ENSMUST00000175971.2 uc290fqz.1 uc290fqz.2 uc290fqz.1 uc290fqz.2 
ENSMUST00000175975.9 Cux1 ENSMUST00000175975.9 cut-like homeobox 1, transcript variant 12 (from RefSeq NM_001405084.1) Cux1 ENSMUST00000175975.1 ENSMUST00000175975.2 ENSMUST00000175975.3 ENSMUST00000175975.4 ENSMUST00000175975.5 ENSMUST00000175975.6 ENSMUST00000175975.7 ENSMUST00000175975.8 H3BK24 H3BK24_MOUSE NM_001405084 uc009aas.1 uc009aas.2 uc009aas.3 uc009aas.4 Nucleus Belongs to the CUT homeobox family. Golgi membrane retrograde transport, vesicle recycling within Golgi DNA binding nucleus nucleoplasm Golgi apparatus regulation of transcription, DNA-templated protein binding, bridging sequence-specific DNA binding uc009aas.1 uc009aas.2 uc009aas.3 uc009aas.4 
ENSMUST00000175989.3 Mir5621 ENSMUST00000175989.3 microRNA 5621 (from RefSeq NR_049194.1) ENSMUST00000175989.1 ENSMUST00000175989.2 NR_049194 uc033gbj.1 uc033gbj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611590.1 [ECO:0000345] ##Evidence-Data-END## uc033gbj.1 uc033gbj.2 
ENSMUST00000176002.3 Mir5626 ENSMUST00000176002.3 microRNA 5626 (from RefSeq NR_049200.1) ENSMUST00000176002.1 ENSMUST00000176002.2 NR_049200 uc033jlf.1 uc033jlf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611595.1 [ECO:0000345] ##Evidence-Data-END## uc033jlf.1 uc033jlf.2 
ENSMUST00000176010.8 Rpl41 ENSMUST00000176010.8 Component of the small ribosomal subunit (Ref.4) (Probable). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII (By similarity). (from UniProt P62947) A6H625 AK012450 ENSMUST00000176010.1 ENSMUST00000176010.2 ENSMUST00000176010.3 ENSMUST00000176010.4 ENSMUST00000176010.5 ENSMUST00000176010.6 ENSMUST00000176010.7 P28751 P62947 Q3UCJ7 RS32_MOUSE uc007hnk.1 uc007hnk.2 uc007hnk.3 uc007hnk.4 Component of the small ribosomal subunit (Ref.4) (Probable). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII (By similarity). Component of the small ribosomal subunit. Cytoplasm Initially thought to be part of the large ribosomal subunit. Crystal structures show eS32/eL41 to be a small ribosomal subunit forming a bridge at the interface of the 2 subunits. Belongs to the eukaryotic ribosomal protein eS32 family. molecular_function structural constituent of ribosome ribosome translation uc007hnk.1 uc007hnk.2 uc007hnk.3 uc007hnk.4 
ENSMUST00000176020.2 Gm3896 ENSMUST00000176020.2 Gm3896 (from geneSymbol) BC072643 ENSMUST00000176020.1 uc009oui.1 uc009oui.2 uc009oui.3 uc009oui.1 uc009oui.2 uc009oui.3 
ENSMUST00000176030.8 Smarca2 ENSMUST00000176030.8 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, transcript variant 10 (from RefSeq NM_001405136.1) ENSMUST00000176030.1 ENSMUST00000176030.2 ENSMUST00000176030.3 ENSMUST00000176030.4 ENSMUST00000176030.5 ENSMUST00000176030.6 ENSMUST00000176030.7 H3BLH0 H3BLH0_MOUSE NM_001405136 Smarca2 uc289rmc.1 uc289rmc.2 Nucleus Belongs to the SNF2/RAD54 helicase family. ATP binding nucleus chromatin remodeling regulation of transcription, DNA-templated SWI/SNF complex hydrolase activity, acting on acid anhydrides ATPase activity histone binding uc289rmc.1 uc289rmc.2 
ENSMUST00000176047.8 Atpaf1 ENSMUST00000176047.8 ATP synthase mitochondrial F1 complex assembly factor 1, transcript variant 1 (from RefSeq NM_181040.5) Atpaf1 ENSMUST00000176047.1 ENSMUST00000176047.2 ENSMUST00000176047.3 ENSMUST00000176047.4 ENSMUST00000176047.5 ENSMUST00000176047.6 ENSMUST00000176047.7 H3BLL2 H3BLL2_MOUSE NM_181040 uc008ufj.1 uc008ufj.2 uc008ufj.3 uc008ufj.4 Mitochondrion Belongs to the ATP11 family. mitochondrion macromolecular complex assembly uc008ufj.1 uc008ufj.2 uc008ufj.3 uc008ufj.4 
ENSMUST00000176059.2 H3c14 ENSMUST00000176059.2 H3 clustered histone 14 (from RefSeq NM_178216.3) A3KMN6 ENSMUST00000176059.1 H3-143 H3-53 H3-B H3-F H3.2 H3.2-221 H3.2-614 H3.2-615 H3.2-616 H32_MOUSE H3b H3c13 H3c14 H3c15 H3c2 H3c3 H3c4 H3c6 H3c7 H3f Hist1h3b Hist1h3c Hist1h3d Hist1h3e Hist1h3f Hist2h3b Hist2h3c1 Hist2h3c2 Hist2h3ca1 Hist2h3ca2 NM_178216 P02295 P02297 P16105 P17269 P17320 P84228 Q60582 Q78E59 Q8CGN9 uc290htq.1 uc290htq.2 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer (By similarity). Interacts with DNAJC9, CHAF1A and CHAF1B (By similarity). P84228; Q8TF76-1: HASPIN; Xeno; NbExp=3; IntAct=EBI-2658213, EBI-15815652; Nucleus. Chromosome. Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity). Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys- 10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H3 family. Sequence=AAH94041.1; Type=Erroneous initiation; Evidence=; Sequence=AAO06264.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter nuclear chromosome chromatin nucleosome nuclear nucleosome DNA binding chromatin binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly macromolecular complex protein heterodimerization activity protein heterotetramerization regulation of gene silencing uc290htq.1 uc290htq.2 
ENSMUST00000176061.2 Gm20681 ENSMUST00000176061.2 Gm20681 (from geneSymbol) ENSMUST00000176061.1 uc292dsf.1 uc292dsf.2 uc292dsf.1 uc292dsf.2 
ENSMUST00000176065.3 Mir5619 ENSMUST00000176065.3 microRNA 5619 (from RefSeq NR_049192.1) ENSMUST00000176065.1 ENSMUST00000176065.2 NR_049192 uc033ikt.1 uc033ikt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611588.1 [ECO:0000345] ##Evidence-Data-END## uc033ikt.1 uc033ikt.2 
ENSMUST00000176069.2 Gm20641 ENSMUST00000176069.2 Gm20641 (from geneSymbol) ENSMUST00000176069.1 uc288smb.1 uc288smb.2 uc288smb.1 uc288smb.2 
ENSMUST00000176074.9 Apol7a ENSMUST00000176074.9 apolipoprotein L 7a, transcript variant 1 (from RefSeq NM_029419.2) Apol7a B2RT54 B2RT54_MOUSE E9Q635 ENSMUST00000176074.1 ENSMUST00000176074.2 ENSMUST00000176074.3 ENSMUST00000176074.4 ENSMUST00000176074.5 ENSMUST00000176074.6 ENSMUST00000176074.7 ENSMUST00000176074.8 NM_029419 uc007wnl.1 uc007wnl.2 uc007wnl.3 uc007wnl.4 Belongs to the apolipoprotein L family. cellular_component extracellular region lipid transport lipid binding lipoprotein metabolic process uc007wnl.1 uc007wnl.2 uc007wnl.3 uc007wnl.4 
ENSMUST00000176106.2 Gm28577 ENSMUST00000176106.2 Gm28577 (from geneSymbol) BC096585 ENSMUST00000176106.1 uc288iwq.1 uc288iwq.2 uc288iwq.1 uc288iwq.2 
ENSMUST00000176107.3 Vmn2r99 ENSMUST00000176107.3 vomeronasal 2, receptor 99 (from RefSeq NM_001104551.2) ENSMUST00000176107.1 ENSMUST00000176107.2 H3BK37 H3BK37_MOUSE NM_001104551 Vmn2r99 uc012ali.1 uc012ali.2 uc012ali.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc012ali.1 uc012ali.2 uc012ali.3 
ENSMUST00000176108.4 ENSMUSG00000121304 ENSMUST00000176108.4 ENSMUSG00000121304 (from geneSymbol) AK039452 ENSMUST00000176108.1 ENSMUST00000176108.2 ENSMUST00000176108.3 uc291irv.1 uc291irv.2 uc291irv.1 uc291irv.2 
ENSMUST00000176109.8 Csrnp3 ENSMUST00000176109.8 Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis. (from UniProt P59055) A3F6Q4 AK082649 CSRN3_MOUSE ENSMUST00000176109.1 ENSMUST00000176109.2 ENSMUST00000176109.3 ENSMUST00000176109.4 ENSMUST00000176109.5 ENSMUST00000176109.6 ENSMUST00000176109.7 Fam130a2 Mbu1 P59055 Q8BUT9 Q8BYL1 Taip2 uc289wne.1 uc289wne.2 Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P59055-1; Sequence=Displayed; Name=2; IsoId=P59055-2; Sequence=VSP_034260; Detected only in the brain of 15 dpc, 18 dpc, newborn and P6 mice (at protein level). Expressed during embryonic development and also detected a week after birth. Expression decreases by 14 days after birth and is not detected in the adult (at protein level). Mice display no obvious defects in development, hematopoiesis or T-cell function. Deletion of Axud1, Csnrp2 and Csnrp3 together causes partial neonatal lethality, suggesting that they have redundant functions. Belongs to the AXUD1 family. Sequence=ABN14256.1; Type=Erroneous initiation; Evidence=; Sequence=BAC30257.1; Type=Erroneous initiation; Evidence=; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus apoptotic process negative regulation of phosphatase activity positive regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc289wne.1 uc289wne.2 
ENSMUST00000176153.2 Pate13 ENSMUST00000176153.2 prostate and testis expressed 13, transcript variant 2 (from RefSeq NM_001378223.1) D3YWX3 ENSMUST00000176153.1 Gm3867 NM_001378223 PAT13_MOUSE Pate-X Pate13 uc292frt.1 uc292frt.2 Secreted Strongly expressed in the epididymis, including the initial segment, caput, corpus and cauda regions. Weakly expressed in prostate. Belongs to the PATE family. molecular_function cellular_component biological_process uc292frt.1 uc292frt.2 
ENSMUST00000176155.3 Dbndd1 ENSMUST00000176155.3 dysbindin domain containing 1, transcript variant 1 (from RefSeq NM_028146.5) DBND1_MOUSE ENSMUST00000176155.1 ENSMUST00000176155.2 NM_028146 Q80XJ9 Q8BMU4 Q9CZ00 uc009nwi.1 uc009nwi.2 uc009nwi.3 uc009nwi.4 uc009nwi.5 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZ00-1; Sequence=Displayed; Name=2; IsoId=Q9CZ00-2; Sequence=VSP_026215; Belongs to the dysbindin family. molecular_function cytoplasm uc009nwi.1 uc009nwi.2 uc009nwi.3 uc009nwi.4 uc009nwi.5 
ENSMUST00000176157.2 Gm20629 ENSMUST00000176157.2 Gm20629 (from geneSymbol) AK142627 ENSMUST00000176157.1 uc290yax.1 uc290yax.2 uc290yax.1 uc290yax.2 
ENSMUST00000176161.8 Ebf2 ENSMUST00000176161.8 Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'- ATTCCCNNGGGAATT-3'. (from UniProt O08792) AK139262 COE2_MOUSE Coe2 ENSMUST00000176161.1 ENSMUST00000176161.2 ENSMUST00000176161.3 ENSMUST00000176161.4 ENSMUST00000176161.5 ENSMUST00000176161.6 ENSMUST00000176161.7 Mmot1 O08792 Q543D5 uc011znu.1 uc011znu.2 uc011znu.3 uc011znu.4 Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'- ATTCCCNNGGGAATT-3'. Forms either a homodimer or a heterodimer with a related family member (PubMed:9151732). Interacts with SIX1 (PubMed:27923061). Nucleus In adult expressed in olfactory epithelium and at a much lower level in Purkinje cells of the cerebellum. In embryo expressed in epithalamus, in cells near the ventricular zone of mesencephalon and on the ventral surface of rhombencephalon, in the developing vomeronasal organ, at a lower level in developing spinal cord. Not expressed in developing retina, inner ear, dorsal root ganglia, trigeminal ganglia and glossopharyngeal ganglia. First detected at 9.0 dpc in the first and second archial arches. At 10.0 dpc and 10.5 dpc, expressed in somites, especially the forming sclerotomes. At 12.5 dpc, found in dorsal root ganglia. At 16.5 dpc, expressed in bone-forming areas and adipose tissues, as well as in specific neural tissues. In bone-forming areas, expressed along the mesenchymal condensation at 14.5 dpc, in the perichondrium and in cells invading the cartilagenous structures at 16.5 dpc. In 18.5 dpc tibias, scattered throughout the trabecular/cancellous bone area. In vitro, expression is induced during differentiation of immature osteoblasts, and then declines. Belongs to the COE family. Sequence=AAB58423.1; Type=Erroneous initiation; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cell fate determination DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated multicellular organism development positive regulation of chromatin binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding protein dimerization activity brown fat cell differentiation adipose tissue development uc011znu.1 uc011znu.2 uc011znu.3 uc011znu.4 
ENSMUST00000176201.2 Gm20707 ENSMUST00000176201.2 Gm20707 (from geneSymbol) AK163132 ENSMUST00000176201.1 uc008vtb.1 uc008vtb.2 uc008vtb.3 uc008vtb.4 uc008vtb.5 uc008vtb.1 uc008vtb.2 uc008vtb.3 uc008vtb.4 uc008vtb.5 
ENSMUST00000176204.8 Peg10 ENSMUST00000176204.8 paternally expressed 10, transcript variant 1 (from RefSeq NM_001040611.1) ENSMUST00000176204.1 ENSMUST00000176204.2 ENSMUST00000176204.3 ENSMUST00000176204.4 ENSMUST00000176204.5 ENSMUST00000176204.6 ENSMUST00000176204.7 Edr Mar2 Mart2 Mef3l1 NM_001040611 PEG10_MOUSE Peg10 Q7TN75 Q9EQ11 Rgag3 uc033iob.1 uc033iob.2 uc033iob.3 This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation, apoptosis and cancer development. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. [provided by RefSeq, Oct 2014]. Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:30951545, PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (PubMed:16341224, PubMed:30951545). Involved at the immediate early stage of adipocyte differentiation (PubMed:17707377). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (By similarity). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (PubMed:9473521). Homooligomer; homooligomerizes into virion-like capsids (PubMed:34413232). Interacts with ACVRL1 (By similarity). Interacts with SIAH1 and SIAH2 (By similarity). Extracellular vesicle membrane Cytoplasm Nucleus Note=Forms virion-like extracellular vesicles that are released from cells. Event=Ribosomal frameshifting; Named isoforms=2; Comment=The ribosomal frameshifting efficiency shows an apparent decrease from 68% at 9.5 dpc to 43% by 21.5 dpc during placenta gestation of isoform 1 compared to isoform 2. ; Name=1; Synonyms=RF1/RF2 , RF1/2 ; IsoId=Q7TN75-1; Sequence=Displayed; Name=2; Synonyms=RF1 ; IsoId=Q7TN75-2; Sequence=VSP_032009, VSP_032010; Expressed in a subset of adult tissues, including brain and testis (PubMed:11574691, PubMed:30951545). Expressed during the early process of adipocyte differentiation (PubMed:17707377). Expressed weakly in mammary gland but strongly in breast carcinomas of a c-MYC-driven transgenic model (PubMed:16423995). [Isoform 1]: Expressed in adrenal gland, testis and placenta (PubMed:30951545). Present at lower level in pituitary, ovary, uterus, white adipose, brain and lung (PubMed:30951545). [Isoform 2]: Expressed in adrenal gland, testis and placenta (PubMed:30951545). Present at lower level in pituitary, ovary, uterus, white adipose, brain and lung (PubMed:30951545). Expressed in embryo, placenta and amniotic membrane at 10.5 dpc (PubMed:17942406, PubMed:25888968). Expressed in placenta at 9.5 dpc and appeared to increase as gestation progresses peaking around 12.5 and 15.5 dpc (at protein level) (PubMed:16341224, PubMed:25888968). Expressed in embryo at 9.5, 12.5 and 16.5 dpc (PubMed:11574691). Expressed in developing musculo-skeletal system, during skeletal myogenesis and also in precartilage primordia and derivative chondrogenic cells of the developing skeleton (PubMed:11574691). Expressed in mesenchymal tissues of developing lung, kidney, gonad, gut and placenta (PubMed:11574691). Not expressed at stages of chondrocyte hypertrophy and ossification of bones (PubMed:11574691). Expressed in all extraembryonic tissues at 9.5 and 12.5 dpc and low-level expression in the embryonic brain and vertebral cartilage at 12.5 dpc (PubMed:11574691). Up-regulated by MYC and during adipocyte differentiation. The protein is evolutionarily related to retrotransposon Gag proteins: it contains the capsid (CA) and nucleocapsid (NC) subdomains of gag. [Isoform 1]: In addition to the capsid (CA) and nucleocapsid (NC) subdomains of gag proteins, this isoform contains subdomains of pol, namely a protease (PRO) domain and a predicted reverse transcriptase (RT)-like domain. Ubiquitinated (PubMed:30951545). Deubiquitinated at Lys-362 and Lys-365 by USP9X (PubMed:30951545). [Isoform 1]: Undergoes proteolytic cleavage. Embryonic lethality resulting from placental defects. Can be reprogrammed to form virion-like capsids that deliver engineered cargo mRNAs bearing RNA signals from PEG10 5'- and 3'-UTR into target cells. The PEG10 locus is imprinted, giving rise to paternally expressed proteins. [Isoform 1]: Produced by a -1 ribosomal frameshifting due to a slippery site occurring between the codons for Gly-370 and Lys-371. [Isoform 2]: Produced by conventional translation. Name=Protein Spotlight; Note=I'll borrow that, thank you - Issue 245 of March 2022; URL="https://web.expasy.org/spotlight/back_issues/245/"; placenta development nucleic acid binding DNA binding nucleus cytoplasm cytosol apoptotic process zinc ion binding cell differentiation negative regulation of transforming growth factor beta receptor signaling pathway metal ion binding uc033iob.1 uc033iob.2 uc033iob.3 
ENSMUST00000176205.8 Zfp536 ENSMUST00000176205.8 zinc finger protein 536, transcript variant 4 (from RefSeq NM_001404094.1) ENSMUST00000176205.1 ENSMUST00000176205.2 ENSMUST00000176205.3 ENSMUST00000176205.4 ENSMUST00000176205.5 ENSMUST00000176205.6 ENSMUST00000176205.7 Kiaa0390 NM_001404094 Q80U15 Q8K083 ZN536_MOUSE Znf536 uc009gkm.1 uc009gkm.2 uc009gkm.3 Transcriptional repressor that negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription (PubMed:19398580). Binds and interrupts RARA from binding to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580). Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3' (By similarity). Nucleus Expressed predominantly in the brain, while a weak signal is also detected in the heart and testis (PubMed:19398580). Expression is abundant in neuronal cells of the cerebral cortex, hippocampus and hypothalamic area (at protein level) (PubMed:19398580). From 9.5 dpc to 12.5 dpc, expressed in the developing central nervous system, dorsal root ganglia, eye vesicles and limbs. At 9.5 dpc, expressed in the developing forebrain, midbrain, hindbrain neural folds and spinal cord. When the embryo developed to 10.5 dpc, expressed in the telencephalic vesicles, midbrain, hindbrain, and spinal cord and is detectable in the dorsal root ganglia region and somites. Similar expression patterns at 11.5 dpc and 12.5 dpc, with significant expression in the telencephalic vesicles, midbrain, hindbrain and spinal cord. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC65552.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus retinoic acid-responsive element binding negative regulation of neuron differentiation metal ion binding negative regulation of retinoic acid receptor signaling pathway uc009gkm.1 uc009gkm.2 uc009gkm.3 
ENSMUST00000176207.8 Hnrnpk ENSMUST00000176207.8 heterogeneous nuclear ribonucleoprotein K, transcript variant 11 (from RefSeq NM_001360495.1) ENSMUST00000176207.1 ENSMUST00000176207.2 ENSMUST00000176207.3 ENSMUST00000176207.4 ENSMUST00000176207.5 ENSMUST00000176207.6 ENSMUST00000176207.7 HNRPK_MOUSE Hnrpk NM_001360495 P61979 Q07244 Q15671 Q60577 Q8BGQ8 Q922Y7 Q96J62 uc007qty.1 uc007qty.2 uc007qty.3 uc007qty.4 The protein encoded by this gene is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, and is a poly-cytosine binding protein (PCBP). It is found in multiple subcellular compartments including the nucleus, cytoplasm and mitochondria. This gene product is thought to interact with RNA, DNA, and protein, and is involved in multiple cellular processes, including transcription, chromatin remodeling, DNA damage response, signal transduction, mRNA splicing, export, and translation. Multiple transcript variants and protein isoforms exist, with some isoforms containing a unique C-terminus. There are four pseudogenes of this gene, found on chromosomes 2, 3, 7 and 13. [provided by RefSeq, Aug 2014]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.176925.1, SRR1660811.61376.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 11741984 ##RefSeq-Attributes-END## One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity). Identified in the spliceosome C complex (By similarity). Interacts with ANKRD28 and RBM42 (By similarity). Interacts with DDX1 (By similarity). Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation (By similarity). Interacts with p53/TP53 (By similarity). Interacts with ZIK1 (PubMed:8910362). Interacts with BRDT (PubMed:22570411). Interacts with IVNS1ABP (By similarity). Interacts with PPIA/CYPA (By similarity). Part of a transcription inhibitory ribonucleoprotein complex composed at least of the circular RNA circZNF827, ZNF827 and HNRNPL (By similarity). Cytoplasm Nucleus, nucleoplasm Cell projection, podosome Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P61979-1, Q07244-1; Sequence=Displayed; Name=2; IsoId=P61979-2, Q07244-2; Sequence=VSP_010622; Name=3; IsoId=P61979-3; Sequence=VSP_012581; By DNA damage. This up-regulation is due to protein stabilization. The constitutive protein levels are controlled by MDM2- mediated ubiquitination and degradation via the proteasome pathway. Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions (By similarity). Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK poly-ubiquitination (By similarity). O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ovarian follicle development podosome nucleic acid binding DNA binding double-stranded DNA binding single-stranded DNA binding RNA binding mRNA 3'-UTR binding protein binding lamin binding nucleus nucleoplasm spliceosomal complex cytoplasm mitochondrion cytosol cell cortex regulation of transcription from RNA polymerase II promoter RNA processing mRNA processing transcription factor binding RNA splicing cytoplasmic stress granule negative regulation of gene expression positive regulation of neuron projection development regulation of low-density lipoprotein particle clearance postsynaptic density protein domain specific binding cerebral cortex development cell junction pre-mRNA 3'-splice site binding heat shock protein binding negative regulation of protein binding cellular response to insulin stimulus protein-DNA complex positive regulation of RNA splicing identical protein binding actinin binding cell projection ribonucleoprotein complex binding negative regulation of apoptotic process dendritic spine axon terminus positive regulation of low-density lipoprotein particle receptor biosynthetic process positive regulation of transcription from RNA polymerase II promoter negative regulation of mRNA splicing, via spliceosome positive regulation of receptor-mediated endocytosis modulation of synaptic transmission positive regulation of synaptic transmission ATPase binding positive regulation of dendritic spine development catalytic step 2 spliceosome regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter positive regulation of synapse maturation postsynapse glutamatergic synapse positive regulation of long-term synaptic potentiation regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of dendrite extension cellular response to forskolin mRNA CDS binding C-rich single-stranded DNA binding positive regulation of protein localization to cell surface negative regulation of branching morphogenesis of a nerve uc007qty.1 uc007qty.2 uc007qty.3 uc007qty.4 
ENSMUST00000176208.3 Gm26505 ENSMUST00000176208.3 Gm26505 (from geneSymbol) DQ548138 ENSMUST00000176208.1 ENSMUST00000176208.2 uc289zif.1 uc289zif.2 uc289zif.1 uc289zif.2 
ENSMUST00000176233.2 Gm20695 ENSMUST00000176233.2 Cell projection, cilium (from UniProt H3BLK7) AK166050 ENSMUST00000176233.1 Gm20695 H3BLK7 H3BLK7_MOUSE uc289bzu.1 uc289bzu.2 Cell projection, cilium Belongs to the CLUAP1 family. centrosome cilium N-acetyltransferase activity intraciliary transport particle B cilium assembly uc289bzu.1 uc289bzu.2 
ENSMUST00000176252.2 Vmn1r7 ENSMUST00000176252.2 vomeronasal 1 receptor 7 (from RefSeq NM_001166710.1) E9Q8T0 E9Q8T0_MOUSE ENSMUST00000176252.1 NM_001166710 Vmn1r7 uc012emm.1 uc012emm.2 uc012emm.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012emm.1 uc012emm.2 uc012emm.3 
ENSMUST00000176268.2 Gm21988 ENSMUST00000176268.2 Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate (By similarity). Regulates the activity of vacuolar (H+)-ATPase (V-ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity). Required at an early stage of receptor-mediated endocytosis (By similarity). (from UniProt Q8K3C0) BC012258 D11Bwg0434e ENSMUST00000176268.1 Q3TAB4 Q8K3C0 RNK_MOUSE Rnasek uc287zpg.1 uc287zpg.2 Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate (By similarity). Regulates the activity of vacuolar (H+)-ATPase (V-ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity). Required at an early stage of receptor-mediated endocytosis (By similarity). Interacts with the proton translocation complex V0 of the V- ATPase (By similarity). Interacts with ATP6AP1 (By similarity). Endomembrane system ; Multi-pass membrane protein Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Multi-pass membrane protein Belongs to the RNase K family. nuclease activity endonuclease activity endoribonuclease activity cellular_component membrane integral component of membrane hydrolase activity nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic uc287zpg.1 uc287zpg.2 
ENSMUST00000176274.2 Zftraf1 ENSMUST00000176274.2 zinc finger TRAF type containing 1, transcript variant 5 (from RefSeq NM_001408207.1) Chrp Cyhr1 ENSMUST00000176274.1 H3BIV6 Kiaa0496 NM_001408207 P0DW87 Q6P6J7 Q6ZQA2 Q9D134 Q9QXA1 ZTRF1_MOUSE Zftraf1 uc007wlh.1 uc007wlh.2 uc007wlh.3 uc007wlh.4 Interacts with LGALS3. Cytoplasm Cytoplasm, perinuclear region Note=Shows a prominent perinuclear and cytoplasmic localization. Event=Alternative splicing; Named isoforms=4; Name=5; IsoId=P0DW87-1, Q9QXA1-5; Sequence=Displayed; Name=1; IsoId=P0DW87-2, Q9QXA1-1; Sequence=VSP_061642; Name=6; IsoId=P0DW87-3, Q9QXA1-6; Sequence=VSP_061641, VSP_061643; Name=7; IsoId=P0DW87-4, Q9QXA1-7; Sequence=VSP_061643; Expressed in heart, brain, liver, testis and kidney. Belongs to the ZFTRAF1 family. Sequence=AAH62184.1; Type=Frameshift; Evidence=; Sequence=AAH82772.1; Type=Frameshift; Evidence=; Sequence=BAC97966.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC97966.1; Type=Frameshift; Evidence=; uc007wlh.1 uc007wlh.2 uc007wlh.3 uc007wlh.4 
ENSMUST00000176278.8 Zbtb25 ENSMUST00000176278.8 zinc finger and BTB domain containing 25, transcript variant 2 (from RefSeq NM_028356.2) ENSMUST00000176278.1 ENSMUST00000176278.2 ENSMUST00000176278.3 ENSMUST00000176278.4 ENSMUST00000176278.5 ENSMUST00000176278.6 ENSMUST00000176278.7 G3UW50 G3UW50_MOUSE NM_028356 Zbtb25 uc011ynz.1 uc011ynz.2 uc011ynz.3 nucleic acid binding DNA binding nucleoplasm cytoplasm gene expression uc011ynz.1 uc011ynz.2 uc011ynz.3 
ENSMUST00000176328.9 Vmn2r3 ENSMUST00000176328.9 vomeronasal 2, receptor 3 (from RefSeq NM_001384949.1) ENSMUST00000176328.1 ENSMUST00000176328.2 ENSMUST00000176328.3 ENSMUST00000176328.4 ENSMUST00000176328.5 ENSMUST00000176328.6 ENSMUST00000176328.7 ENSMUST00000176328.8 H3BJ88 H3BJ88_MOUSE NM_001384949 Vmn2r3 uc290fqo.1 uc290fqo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc290fqo.1 uc290fqo.2 
ENSMUST00000176330.8 Pou1f1 ENSMUST00000176330.8 POU domain, class 1, transcription factor 1, transcript variant 1 (from RefSeq NM_008849.6) ENSMUST00000176330.1 ENSMUST00000176330.2 ENSMUST00000176330.3 ENSMUST00000176330.4 ENSMUST00000176330.5 ENSMUST00000176330.6 ENSMUST00000176330.7 NM_008849 PIT1_MOUSE Pit-1 Pit1 Q00286 uc007zqi.1 uc007zqi.2 uc007zqi.3 Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. Interacts with PITX1. Interacts with LHX3. Interacts with ELK1. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Pit-1; IsoId=Q00286-1; Sequence=Displayed; Name=2; Synonyms=Pit-1T; IsoId=Q00286-2; Sequence=VSP_012550; Name=3; Synonyms=Pit-1a, Pit-1 beta; IsoId=Q00286-3; Sequence=VSP_012551; The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Note=Defects in Pou1f1 are the cause of the dwarf (dw) phenotype which interrupts the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. [Isoform 3]: Unable to transactivate. Only about 1/7 as abundant as isoform 1. Belongs to the POU transcription factor family. Class-1 subfamily. negative regulation of transcription from RNA polymerase II promoter chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cell fate specification DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus transcription factor complex regulation of transcription, DNA-templated positive regulation of cell proliferation determination of adult lifespan pituitary gland development adenohypophysis development B cell differentiation positive regulation of inositol trisphosphate biosynthetic process positive regulation of multicellular organism growth sequence-specific DNA binding regulation of insulin-like growth factor receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter somatotropin secreting cell differentiation somatotropin secreting cell development uc007zqi.1 uc007zqi.2 uc007zqi.3 
ENSMUST00000176344.2 Gm20713 ENSMUST00000176344.2 Gm20713 (from geneSymbol) ENSMUST00000176344.1 uc288wle.1 uc288wle.2 uc288wle.1 uc288wle.2 
ENSMUST00000176356.8 Gm20662 ENSMUST00000176356.8 Gm20662 (from geneSymbol) AK147906 ENSMUST00000176356.1 ENSMUST00000176356.2 ENSMUST00000176356.3 ENSMUST00000176356.4 ENSMUST00000176356.5 ENSMUST00000176356.6 ENSMUST00000176356.7 Gm20662 H3BK64 H3BK64_MOUSE uc292laq.1 uc292laq.2 uc292laq.1 uc292laq.2 
ENSMUST00000176369.2 Mrgpra3 ENSMUST00000176369.2 MAS-related GPR, member A3 (from RefSeq NM_153067.2) ENSMUST00000176369.1 H3BKL3 H3BKL3_MOUSE Mrgpra3 NM_153067 uc009haj.1 uc009haj.2 uc009haj.3 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc009haj.1 uc009haj.2 uc009haj.3 
ENSMUST00000176381.8 Stx5a ENSMUST00000176381.8 syntaxin 5A, transcript variant 2 (from RefSeq NM_001167799.1) ENSMUST00000176381.1 ENSMUST00000176381.2 ENSMUST00000176381.3 ENSMUST00000176381.4 ENSMUST00000176381.5 ENSMUST00000176381.6 ENSMUST00000176381.7 NM_001167799 Q3TM79 Q8K1E0 Q99J28 Q9JKP2 STX5_MOUSE Stx5 uc008gmo.1 uc008gmo.2 uc008gmo.3 uc008gmo.4 Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter- connected structure of the Golgi apparatus. Part of a ternary complex containing STX5A, NSFL1C and VCP. Part of a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2, YKT6 and VTI1A (PubMed:9705316). Interacts with COG4 (By similarity). Interacts with GM130/GOLGA2 (By similarity). Interacts (via IxM motif) with SEC24C and SEC24D; mediates STX5 packaging into COPII-coated vesicles (By similarity). Interacts with VLDLR; this interaction mediates VLDLR translocation from the endoplasmic reticulum to the plasma membrane (By similarity). Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type IV membrane protein Golgi apparatus membrane Note=Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=Q8K1E0-1; Sequence=Displayed; Name=2; IsoId=Q8K1E0-2; Sequence=VSP_020118; [Isoform 2]: Produced by alternative initiation at Met- 55 of isoform 1. Belongs to the syntaxin family. It is uncertain whether Met-1 or Met-55 is the initiator. However, for the rat ortholog it has been shown that the equivalent alternative isoform is produced by alternative initiation at a conserved initiator methionine at position 55. Sequence=AAH04849.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH21883.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi membrane SNARE binding SNAP receptor activity endoplasmic reticulum Golgi apparatus cytosol intracellular protein transport ER to Golgi vesicle-mediated transport vesicle fusion endomembrane system membrane integral component of membrane vesicle-mediated transport SNARE complex vesicle endoplasmic reticulum-Golgi intermediate compartment membrane early endosome to Golgi transport retrograde transport, endosome to Golgi positive regulation of protein catabolic process protein N-terminus binding vesicle docking vesicle fusion with Golgi apparatus Golgi disassembly regulation of Golgi organization uc008gmo.1 uc008gmo.2 uc008gmo.3 uc008gmo.4 
ENSMUST00000176387.2 Gm20712 ENSMUST00000176387.2 Gm20712 (from geneSymbol) ENSMUST00000176387.1 LF200260 uc288yer.1 uc288yer.2 uc288yer.1 uc288yer.2 
ENSMUST00000176396.2 Gm20647 ENSMUST00000176396.2 Gm20647 (from geneSymbol) AK015832 ENSMUST00000176396.1 uc290wfr.1 uc290wfr.2 uc290wfr.1 uc290wfr.2 
ENSMUST00000176403.8 Prss46 ENSMUST00000176403.8 serine protease 46 (from RefSeq NM_183103.3) ENSMUST00000176403.1 ENSMUST00000176403.2 ENSMUST00000176403.3 ENSMUST00000176403.4 ENSMUST00000176403.5 ENSMUST00000176403.6 ENSMUST00000176403.7 NM_183103 PRS46_MOUSE Q5M8S2 Q8C1Q8 uc009ruy.1 uc009ruy.2 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5M8S2-1; Sequence=Displayed; Name=2; IsoId=Q5M8S2-2; Sequence=VSP_044025; Belongs to the peptidase S1 family. Sequence=BAC25167.1; Type=Frameshift; Evidence=; serine-type endopeptidase activity extracellular space proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc009ruy.1 uc009ruy.2 
ENSMUST00000176438.9 Zeb2 ENSMUST00000176438.9 zinc finger E-box binding homeobox 2, transcript variant 4 (from RefSeq NM_001355288.2) ENSMUST00000176438.1 ENSMUST00000176438.2 ENSMUST00000176438.3 ENSMUST00000176438.4 ENSMUST00000176438.5 ENSMUST00000176438.6 ENSMUST00000176438.7 ENSMUST00000176438.8 NM_001355288 Q6P9M5 Q9R0G7 Sip1 ZEB2_MOUSE Zfhx1b Zfx1b uc008jpj.1 uc008jpj.2 uc008jpj.3 Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E-cadherin. Represses expression of MEOX2. Interacts with CBX4 and CTBP1 (By similarity). Binds activated SMAD1, activated SMAD2 and activated SMAD3; binding with SMAD4 is not detected (By similarity). Nucleus Chromosome Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO- protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. negative regulation of transcription from RNA polymerase II promoter nuclear chromatin transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding neural crest cell migration somitogenesis neural tube closure nucleic acid binding DNA binding nucleus nucleolus cytosol central nervous system development corpus callosum morphogenesis hippocampus development cell proliferation in forebrain corticospinal tract morphogenesis positive regulation of Wnt signaling pathway positive regulation of JUN kinase activity sequence-specific DNA binding positive regulation of melanocyte differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of melanin biosynthetic process developmental pigmentation embryonic morphogenesis collateral sprouting positive regulation of axonogenesis mammillary axonal complex development R-SMAD binding melanocyte migration positive regulation of lens fiber cell differentiation regulation of melanosome organization uc008jpj.1 uc008jpj.2 uc008jpj.3 
ENSMUST00000176467.8 Gvin2 ENSMUST00000176467.8 GTPase, very large interferon inducible, family member 2, transcript variant 1 (from RefSeq NM_001243039.1) ENSMUST00000176467.1 ENSMUST00000176467.2 ENSMUST00000176467.3 ENSMUST00000176467.4 ENSMUST00000176467.5 ENSMUST00000176467.6 ENSMUST00000176467.7 GVIN1_MOUSE Gvin1 NM_001243039 Q3U3F2 Q80SU7 Q8BL18 Q8CBA9 uc009izn.1 uc009izn.2 uc009izn.3 uc009izn.4 Cytoplasm, cytosol Nucleus Widely expressed. Expressed at low basal level in lung, heart, thymus and spleen; at still lower level in liver, ovary, kidney and brain. Expressed at very weak level in testis. Undetectable in embryo. By interferons. Induced both in response to IFN type I (IFN- alpha and -beta) and IFN type II (IFN-gamma). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family. Sequence=BAC32832.1; Type=Erroneous initiation; Evidence=; nucleotide binding molecular_function GTP binding cellular_component nucleus cytoplasm cytosol biological_process uc009izn.1 uc009izn.2 uc009izn.3 uc009izn.4 
ENSMUST00000176473.3 9530056K15Rik ENSMUST00000176473.3 9530056K15Rik (from geneSymbol) AK038791 ENSMUST00000176473.1 ENSMUST00000176473.2 uc009akg.1 uc009akg.2 uc009akg.3 uc009akg.1 uc009akg.2 uc009akg.3 
ENSMUST00000176481.9 Vmn2r6 ENSMUST00000176481.9 vomeronasal 2, receptor 6 (from RefSeq NM_001385213.1) ENSMUST00000176481.1 ENSMUST00000176481.2 ENSMUST00000176481.3 ENSMUST00000176481.4 ENSMUST00000176481.5 ENSMUST00000176481.6 ENSMUST00000176481.7 ENSMUST00000176481.8 H3BK29 H3BK29_MOUSE NM_001385213 Vmn2r4 Vmn2r6 uc290fri.1 uc290fri.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc290fri.1 uc290fri.2 
ENSMUST00000176493.8 Cyp2c53-ps ENSMUST00000176493.8 cytochrome P450, family 2, subfamily c, polypeptide 53, pseudogene (from RefSeq NR_033614.2) ENSMUST00000176493.1 ENSMUST00000176493.2 ENSMUST00000176493.3 ENSMUST00000176493.4 ENSMUST00000176493.5 ENSMUST00000176493.6 ENSMUST00000176493.7 NR_033614 uc008hjx.1 uc008hjx.2 uc008hjx.3 uc008hjx.1 uc008hjx.2 uc008hjx.3 
ENSMUST00000176537.3 Mir5615-2 ENSMUST00000176537.3 microRNA 5615-2 (from RefSeq NR_049187.1) ENSMUST00000176537.1 ENSMUST00000176537.2 NR_049187 uc033frk.1 uc033frk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611584.1 [ECO:0000345] ##Evidence-Data-END## uc033frk.1 uc033frk.2 
ENSMUST00000176540.8 Pbx1 ENSMUST00000176540.8 pre B cell leukemia homeobox 1, transcript variant a (from RefSeq NM_183355.3) ENSMUST00000176540.1 ENSMUST00000176540.2 ENSMUST00000176540.3 ENSMUST00000176540.4 ENSMUST00000176540.5 ENSMUST00000176540.6 ENSMUST00000176540.7 NM_183355 P41778 PBX1_MOUSE Pbx-1 uc007dle.1 uc007dle.2 uc007dle.3 uc007dle.4 This gene encodes a homeobox protein that belongs to the three-amino-acid loop extension/Pre-B cell leukemia transcription factor (TALE/PBX) family of proteins. The encoded protein is involved in several biological processes during embryogenesis including steroidogenesis, sexual development and the maintenance of hematopoietic stem cells. This protein functions in the development of several organ systems and plays a role in skeletal patterning and programming. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. Transcription factor which binds the DNA sequence 5'- TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (By similarity). Binds the DNA sequence 5'- TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (By similarity). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:7791786). Acts as a transcriptional activator of PF4 in complex with MEIS1 (By similarity). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (PubMed:19799567). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (PubMed:32190943). Plays a role in the cAMP- dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (PubMed:7913464). Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4 (By similarity). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (PubMed:22560297). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. (Microbial infection) In complex with PREP1, binds to the 5'- TGATTGAC-3' consensus sequence in the U5 region of Moloney murine leukemia virus and promotes viral transcription. Forms a heterodimer with MEIS1 which binds DNA (PubMed:9525891, PubMed:19799567). The PBX1-MEIS1 heterodimer binds a cAMP-responsive sequence in CYP17 (PubMed:9525891). It also binds a consensus region in the SOX3 promoter (PubMed:19799567). PBX1 forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10 (PubMed:9315626, PubMed:10082572, PubMed:10523646, PubMed:12409300). Forms heterodimers with HOXA1, HOXA5, HOXB7 and HOXB8 which bind the 5'-TGATTGAT-3' consensus sequence (By similarity). Also forms heterodimers with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 which bind the 5'-ATCAATCAA-3' consensus sequence (PubMed:7791786). Interacts with PBXIP1 (By similarity). Interacts with TLX1 (By similarity). Interacts with FOXC1 (By similarity). Interacts with MN1 (By similarity). [Isoform PBX1a]: Interacts with MEIS2 isoform Meis2D, SP1, SP3 and KLF4. [Isoform PBX1b]: Part of a PDX1:PBX1b:MEIS2B complex; PBX1b recruits MEIS2B to the complex. P41778; P09631: Hoxa9; NbExp=2; IntAct=EBI-6996259, EBI-925334; P41778; P09023: Hoxb6; NbExp=2; IntAct=EBI-6996259, EBI-15992861; P41778; P09632: Hoxb8; NbExp=4; IntAct=EBI-6996259, EBI-925374; Nucleus Event=Alternative splicing; Named isoforms=2; Name=PBX1a; IsoId=P41778-1; Sequence=Displayed; Name=PBX1b; IsoId=P41778-2; Sequence=VSP_002273, VSP_002274; Expressed constitutively in natural killer cell precursors in bone marrow. The homeobox is required for PBX1 nuclear localization and for transcriptional activation of NFIL3. Conditional knockout in hematopoietic cells leads to a reduction in the number of natural killer cell-committed progenitors in bone marrow, decreases the number of natural killer cells in bone marrow and spleen and reduces NFIL3 expression in bone marrow and splenic natural killer cells. Belongs to the TALE/PBX homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding urogenital system development branching involved in ureteric bud morphogenesis DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm regulation of transcription, DNA-templated steroid biosynthetic process multicellular organism development sex differentiation transcription factor binding positive regulation of cell proliferation animal organ morphogenesis anterior/posterior pattern specification proximal/distal pattern formation positive regulation of G2/M transition of mitotic cell cycle cell differentiation regulation of ossification adrenal gland development embryonic limb morphogenesis embryonic hemopoiesis regulation of cell proliferation negative regulation of sequence-specific DNA binding transcription factor activity sequence-specific DNA binding negative regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity spleen development thymus development embryonic organ development embryonic skeletal system development RNA polymerase II transcription factor complex uc007dle.1 uc007dle.2 uc007dle.3 uc007dle.4 
ENSMUST00000176545.4 AA465934 ENSMUST00000176545.4 AA465934 (from geneSymbol) ENSMUST00000176545.1 ENSMUST00000176545.2 ENSMUST00000176545.3 KY467468 uc288awe.1 uc288awe.2 uc288awe.3 uc288awe.4 uc288awe.1 uc288awe.2 uc288awe.3 uc288awe.4 
ENSMUST00000176549.2 Gm56904 ENSMUST00000176549.2 Gm56904 (from geneSymbol) ENSMUST00000176549.1 uc289mop.1 uc289mop.2 uc289mop.1 uc289mop.2 
ENSMUST00000176552.2 Gm20682 ENSMUST00000176552.2 Gm20682 (from geneSymbol) ENSMUST00000176552.1 uc288iod.1 uc288iod.2 uc288iod.1 uc288iod.2 
ENSMUST00000176572.3 Vmn1r25 ENSMUST00000176572.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt H3BLP0) ENSMUST00000176572.1 ENSMUST00000176572.2 H3BLP0 H3BLP0_MOUSE Vmn1r25 uc291evp.1 uc291evp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291evp.1 uc291evp.2 
ENSMUST00000176577.2 Fbxw10 ENSMUST00000176577.2 F-box and WD-40 domain protein 10, transcript variant 1 (from RefSeq NM_001291441.2) ENSMUST00000176577.1 Fbxw10 H3BLP9 H3BLP9_MOUSE NM_001291441 uc011xwg.1 uc011xwg.2 uc011xwg.3 uc011xwg.1 uc011xwg.2 uc011xwg.3 
ENSMUST00000176586.2 Gm2350 ENSMUST00000176586.2 Gm2350 (from geneSymbol) ENSMUST00000176586.1 uc289ntv.1 uc289ntv.2 uc289ntv.1 uc289ntv.2 
ENSMUST00000176598.3 Mir5625 ENSMUST00000176598.3 microRNA 5625 (from RefSeq NR_049199.1) ENSMUST00000176598.1 ENSMUST00000176598.2 NR_049199 uc033iij.1 uc033iij.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iij.1 uc033iij.2 
ENSMUST00000176600.8 Pan3 ENSMUST00000176600.8 PAN3 poly(A) specific ribonuclease subunit, transcript variant 7 (from RefSeq NM_001419786.1) ENSMUST00000176600.1 ENSMUST00000176600.2 ENSMUST00000176600.3 ENSMUST00000176600.4 ENSMUST00000176600.5 ENSMUST00000176600.6 ENSMUST00000176600.7 H3BKF3 NM_001419786 PAN3_MOUSE Pan3 Q3U5F2 Q640Q5 Q8CE75 Q9CZM6 uc291bvr.1 uc291bvr.2 Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decapping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. [Isoform 1]: Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway. Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A. [Isoform 3]: Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD). Its activity is required for efficient P-body formation. May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation. Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C (By similarity). Interacts with YTHDF3 (PubMed:32905781). [Isoform 1]: Interacts with PAN2. Interacts (via N-terminus) with PABPC1 at lower efficiency than isoform 3. [Isoform 3]: Interacts with PAN2. Interacts (via N-terminus) with PABPC1 at higher efficiency than isoform 1. Cytoplasm, P-body [Isoform 1]: Cytoplasm Nucleus Note=Shuttles between cytoplasm and nucleus. [Isoform 3]: Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Pan3L ; IsoId=Q640Q5-5; Sequence=Displayed; Name=3; Synonyms=Pan3S ; IsoId=Q640Q5-1; Sequence=VSP_061950, VSP_061951; Name=2; IsoId=Q640Q5-2; Sequence=VSP_041650, VSP_041651; The N-terminal zinc finger binds to poly(A) RNA. Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs. The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the protein kinase superfamily. PAN3 family. Sequence=AAH82547.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; Sequence=BAB28221.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAE32127.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence=; nucleotide binding nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA poly(A) tail shortening deadenylation-dependent decapping of nuclear-transcribed mRNA P-body RNA binding poly(A)-specific ribonuclease activity protein kinase activity protein binding ATP binding cytoplasm mRNA processing protein phosphorylation protein targeting positive regulation of cytoplasmic mRNA processing body assembly PAN complex metal ion binding RNA phosphodiester bond hydrolysis, exonucleolytic uc291bvr.1 uc291bvr.2 
ENSMUST00000176610.9 Taf6l ENSMUST00000176610.9 TATA-box binding protein associated factor 6 like, transcript variant 1 (from RefSeq NM_146092.2) ENSMUST00000176610.1 ENSMUST00000176610.2 ENSMUST00000176610.3 ENSMUST00000176610.4 ENSMUST00000176610.5 ENSMUST00000176610.6 ENSMUST00000176610.7 ENSMUST00000176610.8 H3BK01 H3BK01_MOUSE NM_146092 Taf6l uc008gmx.1 uc008gmx.2 uc008gmx.3 uc008gmx.4 Nucleus Belongs to the TAF6 family. SAGA complex transcription coactivator activity histone acetyltransferase activity nucleus nucleoplasm transcription factor TFIID complex DNA-templated transcription, initiation regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter STAGA complex histone H3 acetylation SLIK (SAGA-like) complex protein heterodimerization activity positive regulation of nucleic acid-templated transcription uc008gmx.1 uc008gmx.2 uc008gmx.3 uc008gmx.4 
ENSMUST00000176618.2 Gm20621 ENSMUST00000176618.2 Gm20621 (from geneSymbol) AK006138 ENSMUST00000176618.1 uc007xer.1 uc007xer.2 uc007xer.3 uc007xer.1 uc007xer.2 uc007xer.3 
ENSMUST00000176631.3 Mir5623 ENSMUST00000176631.3 microRNA 5623 (from RefSeq NR_049196.1) ENSMUST00000176631.1 ENSMUST00000176631.2 NR_049196 uc033hlg.1 uc033hlg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611592.1 [ECO:0000345] ##Evidence-Data-END## uc033hlg.1 uc033hlg.2 
ENSMUST00000176635.3 Mir5624 ENSMUST00000176635.3 microRNA 5624 (from RefSeq NR_049198.1) ENSMUST00000176635.1 ENSMUST00000176635.2 NR_049198 uc033gms.1 uc033gms.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611594.1 [ECO:0000345] ##Evidence-Data-END## uc033gms.1 uc033gms.2 
ENSMUST00000176636.5 Pou2f3 ENSMUST00000176636.5 POU domain, class 2, transcription factor 3 (from RefSeq NM_011139.2) ENSMUST00000176636.1 ENSMUST00000176636.2 ENSMUST00000176636.3 ENSMUST00000176636.4 Epoc1 H3BJT4 NM_011139 Oct11 Otf-11 Otf11 P31362 PO2F3_MOUSE uc009pbe.1 uc009pbe.2 Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') (PubMed:8441607). Regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:9242494). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (By similarity). Interacts (via the POU domain) with POU2AF1 and POU2AF2 in a DNA-dependent manner; this interaction recruits POU2AF2 to chromatin and increases POU2F3 transactivation activity. Nucleus Skin, thymus, stomach and testis. Mice homozygous for null mutation exhibit defective keratinocyte differentiation, however the skin and coat appear normal. Belongs to the POU transcription factor family. Class-2 subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter epidermis development keratinocyte differentiation wound healing identical protein binding sequence-specific DNA binding negative regulation by host of viral transcription positive regulation of transcription from RNA polymerase II promoter uc009pbe.1 uc009pbe.2 
ENSMUST00000176647.2 Gm20663 ENSMUST00000176647.2 Gm20663 (from geneSymbol) ENSMUST00000176647.1 uc291ubr.1 uc291ubr.2 uc291ubr.1 uc291ubr.2 
ENSMUST00000176652.8 Traf7 ENSMUST00000176652.8 TNF receptor-associated factor 7, transcript variant 3 (from RefSeq NM_153792.2) ENSMUST00000176652.1 ENSMUST00000176652.2 ENSMUST00000176652.3 ENSMUST00000176652.4 ENSMUST00000176652.5 ENSMUST00000176652.6 ENSMUST00000176652.7 F8WJF7 F8WJF7_MOUSE NM_153792 Traf7 uc012aml.1 uc012aml.2 uc012aml.3 ubiquitin ligase complex activation of MAPKKK activity ubiquitin-protein transferase activity plasma membrane apoptotic process zinc ion binding protein ubiquitination intracellular membrane-bounded organelle positive regulation of MAPK cascade metal ion binding regulation of ERK1 and ERK2 cascade positive regulation of apoptotic signaling pathway uc012aml.1 uc012aml.2 uc012aml.3 
ENSMUST00000176660.2 Gm20636 ENSMUST00000176660.2 Gm20636 (from geneSymbol) BC049677 ENSMUST00000176660.1 uc290yjq.1 uc290yjq.2 uc290yjq.1 uc290yjq.2 
ENSMUST00000176684.8 Irx4 ENSMUST00000176684.8 Iroquois homeobox 4, transcript variant 2 (from RefSeq NM_001426554.1) A0JNT5 ENSMUST00000176684.1 ENSMUST00000176684.2 ENSMUST00000176684.3 ENSMUST00000176684.4 ENSMUST00000176684.5 ENSMUST00000176684.6 ENSMUST00000176684.7 IRX4_MOUSE Irxa3 NM_001426554 Q3V1B6 Q9QY61 uc288oks.1 uc288oks.2 Likely to be an important mediator of ventricular differentiation during cardiac development. Interacts with the vitamin D receptor VDR but doesn't affect its transactivation activity. Nucleus Expressed in the developing central nervous system, skin, and vibrissae, but predominantly expressed in the cardiac ventricles of the developing heart. Not expressed in the developing metanephric kidney or adult kidney. Belongs to the TALE/IRO homeobox family. DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development heart development cell differentiation sequence-specific DNA binding establishment of animal organ orientation uc288oks.1 uc288oks.2 
ENSMUST00000176696.3 Wfikkn1 ENSMUST00000176696.3 WAP, FS, Ig, KU, and NTR-containing protein 1 (from RefSeq NM_001100454.1) ENSMUST00000176696.1 ENSMUST00000176696.2 Gasp2 NM_001100454 Q8R0S6 WFKN1_MOUSE uc289iml.1 uc289iml.2 uc289iml.3 Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease- inhibitor activity (By similarity). Secreted The second BPTI/Kunitz inhibitor domain is able to inhibit trypsin. It has however no activity toward chymotrypsin, elastase, plasmin, pancreatic kallikrein, lung tryptase, plasma kallikrein, thrombin, urokinase or tissue plasminogen activator (By similarity). Belongs to the WFIKKN family. skeletal system development enzyme inhibitor activity serine-type endopeptidase inhibitor activity protein binding extracellular region metalloendopeptidase inhibitor activity negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of protein binding negative regulation of DNA binding negative regulation of proteolysis receptor antagonist activity muscle fiber development transforming growth factor beta binding palate development negative regulation of receptor activity uc289iml.1 uc289iml.2 uc289iml.3 
ENSMUST00000176703.3 9330154K18Rik ENSMUST00000176703.3 9330154K18Rik (from geneSymbol) AK041483 ENSMUST00000176703.1 ENSMUST00000176703.2 uc056yyu.1 uc056yyu.2 uc056yyu.1 uc056yyu.2 
ENSMUST00000176721.2 Gm20644 ENSMUST00000176721.2 Gm20644 (from geneSymbol) ENSMUST00000176721.1 LF273798 uc288bxs.1 uc288bxs.2 uc288bxs.1 uc288bxs.2 
ENSMUST00000176742.2 Gm20633 ENSMUST00000176742.2 Gm20633 (from geneSymbol) ENSMUST00000176742.1 LF194086 uc290htn.1 uc290htn.2 uc290htn.1 uc290htn.2 
ENSMUST00000176749.3 Gm20700 ENSMUST00000176749.3 Gm20700 (from geneSymbol) ENSMUST00000176749.1 ENSMUST00000176749.2 uc290vjq.1 uc290vjq.2 uc290vjq.1 uc290vjq.2 
ENSMUST00000176751.2 Gm20683 ENSMUST00000176751.2 Gm20683 (from geneSymbol) BC023948 ENSMUST00000176751.1 Gm20683 H3BKJ1 H3BKJ1_MOUSE uc289ile.1 uc289ile.2 GTPase activity calcium ion binding GTP binding membrane integral component of membrane uc289ile.1 uc289ile.2 
ENSMUST00000176760.2 Gm20632 ENSMUST00000176760.2 Gm20632 (from geneSymbol) AK028129 ENSMUST00000176760.1 uc290htl.1 uc290htl.2 uc290htl.1 uc290htl.2 
ENSMUST00000176762.3 Gm20717 ENSMUST00000176762.3 Gm20717 (from geneSymbol) ENSMUST00000176762.1 ENSMUST00000176762.2 uc288yjk.1 uc288yjk.2 uc288yjk.1 uc288yjk.2 
ENSMUST00000176779.2 Gm20688 ENSMUST00000176779.2 Gm20688 (from geneSymbol) ENSMUST00000176779.1 uc288zhz.1 uc288zhz.2 uc288zhz.1 uc288zhz.2 
ENSMUST00000176781.8 Gm56298 ENSMUST00000176781.8 Gm56298 (from geneSymbol) BC026552 ENSMUST00000176781.1 ENSMUST00000176781.2 ENSMUST00000176781.3 ENSMUST00000176781.4 ENSMUST00000176781.5 ENSMUST00000176781.6 ENSMUST00000176781.7 uc290rkn.1 uc290rkn.2 uc290rkn.1 uc290rkn.2 
ENSMUST00000176783.3 Mir5709 ENSMUST00000176783.3 microRNA 5709 (from RefSeq NR_049205.1) ENSMUST00000176783.1 ENSMUST00000176783.2 NR_049205 uc033hey.1 uc033hey.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611620.1 [ECO:0000345] ##Evidence-Data-END## uc033hey.1 uc033hey.2 
ENSMUST00000176786.3 Mir5617 ENSMUST00000176786.3 microRNA 5617 (from RefSeq NR_049190.1) ENSMUST00000176786.1 ENSMUST00000176786.2 NR_049190 uc033jou.1 uc033jou.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611587.1 [ECO:0000345] ##Evidence-Data-END## uc033jou.1 uc033jou.2 
ENSMUST00000176802.3 Vmn2r124 ENSMUST00000176802.3 vomeronasal 2, receptor 124 (from RefSeq NM_001271883.1) ENSMUST00000176802.1 ENSMUST00000176802.2 K7N789 K7N789_MOUSE NM_001271883 Vmn2r124 uc033hbe.1 uc033hbe.2 uc033hbe.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc033hbe.1 uc033hbe.2 uc033hbe.3 
ENSMUST00000176819.8 Cd200r4 ENSMUST00000176819.8 CD200 receptor 4 (from RefSeq NM_207244.3) ENSMUST00000176819.1 ENSMUST00000176819.2 ENSMUST00000176819.3 ENSMUST00000176819.4 ENSMUST00000176819.5 ENSMUST00000176819.6 ENSMUST00000176819.7 MO2R4_MOUSE NM_207244 Q6XJV4 uc289evb.1 uc289evb.2 Involved in the recruitment or surface expression of the TYROBP receptor. Interacts with TYROBP. Membrane ; Single-pass type I membrane protein Highly expressed in monocytes, NK cells and a subset of NKT cells. Weakly expressed in granulocytes and B-cells (at protein level). Expressed in brain, lung, testis, thymus, intestine and uterus. Expressed in bone marrow derived-macrophage and dendritic cells and mast cells. Belongs to the CD200R family. May be expressed in adult splenic cells (PubMed:15187158), as the antibody used could not discriminate between CD200R1 and CD200R4. May be expressed in uterus at 12.5 dpc (at protein level) (PubMed:15274657), as the antibody used could not discriminate between CD200R1 and CD200R4. According to some authors (PubMed:15187158), CD200R4 is a receptor for the CD200/OX2 cell surface glycoprotein, but it was later found (PubMed:23602662) to miss key amino-acids for binding to CD200. protein binding external side of plasma membrane membrane integral component of membrane signaling receptor activity uc289evb.1 uc289evb.2 
ENSMUST00000176824.8 Sik2 ENSMUST00000176824.8 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; (from UniProt H3BJC9) AK090386 ENSMUST00000176824.1 ENSMUST00000176824.2 ENSMUST00000176824.3 ENSMUST00000176824.4 ENSMUST00000176824.5 ENSMUST00000176824.6 ENSMUST00000176824.7 H3BJC9 H3BJC9_MOUSE Sik2 uc292hfe.1 uc292hfe.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation intracellular signal transduction uc292hfe.1 uc292hfe.2 
ENSMUST00000176825.3 Evi5l ENSMUST00000176825.3 ecotropic viral integration site 5 like, transcript variant 5 (from RefSeq NM_001368794.1) ENSMUST00000176825.1 ENSMUST00000176825.2 Evi5l H3BL92 H3BL92_MOUSE NM_001368794 uc291xwe.1 uc291xwe.2 GTPase activator activity cell intracellular protein transport Rab GTPase binding regulation of GTPase activity activation of GTPase activity uc291xwe.1 uc291xwe.2 
ENSMUST00000176826.2 Osmr ENSMUST00000176826.2 oncostatin M receptor, transcript variant 2 (from RefSeq NM_001310469.2) A0A0R4J268 A0A0R4J268_MOUSE ENSMUST00000176826.1 NM_001310469 Osmr uc011zrc.1 uc011zrc.2 uc011zrc.3 Belongs to the type I cytokine receptor family. Type 2 subfamily. cytokine receptor activity membrane integral component of membrane cytokine-mediated signaling pathway uc011zrc.1 uc011zrc.2 uc011zrc.3 
ENSMUST00000176838.2 Vmn1r4 ENSMUST00000176838.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2D3) AK082576 ENSMUST00000176838.1 Q8R2D3 Q8R2D3_MOUSE V1rc21 Vmn1r4 uc009cbs.1 uc009cbs.2 uc009cbs.3 uc009cbs.4 uc009cbs.5 uc009cbs.6 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009cbs.1 uc009cbs.2 uc009cbs.3 uc009cbs.4 uc009cbs.5 uc009cbs.6 
ENSMUST00000176841.3 4930438E09Rik ENSMUST00000176841.3 RIKEN cDNA 4930438E09 gene (from RefSeq NR_045961.1) ENSMUST00000176841.1 ENSMUST00000176841.2 NR_045961 uc007ukz.1 uc007ukz.2 uc007ukz.3 uc007ukz.1 uc007ukz.2 uc007ukz.3 
ENSMUST00000176850.8 Foxp1 ENSMUST00000176850.8 Nucleus (from UniProt H3BJM1) AB594192 ENSMUST00000176850.1 ENSMUST00000176850.2 ENSMUST00000176850.3 ENSMUST00000176850.4 ENSMUST00000176850.5 ENSMUST00000176850.6 ENSMUST00000176850.7 Foxp1 H3BJM1 H3BJM1_MOUSE uc291hjw.1 uc291hjw.2 Nucleus DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding uc291hjw.1 uc291hjw.2 
ENSMUST00000176875.4 Duxf3 ENSMUST00000176875.4 Nucleus (from UniProt A0A0N4SV92) A0A0N4SV92 A0A0N4SV92_MOUSE Duxf3 ENSMUST00000176875.1 ENSMUST00000176875.2 ENSMUST00000176875.3 NM_001081954 uc287rja.1 uc287rja.2 Nucleus DNA binding nucleus regulation of transcription from RNA polymerase II promoter RSC complex neuron differentiation sequence-specific DNA binding uc287rja.1 uc287rja.2 
ENSMUST00000176884.3 Mir5710 ENSMUST00000176884.3 microRNA 5710 (from RefSeq NR_049206.1) ENSMUST00000176884.1 ENSMUST00000176884.2 NR_049206 uc033jkq.1 uc033jkq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611621.1 [ECO:0000345] ##Evidence-Data-END## uc033jkq.1 uc033jkq.2 
ENSMUST00000176903.3 Mir5620 ENSMUST00000176903.3 microRNA 5620 (from RefSeq NR_049193.1) ENSMUST00000176903.1 ENSMUST00000176903.2 NR_049193 uc033iwo.1 uc033iwo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611589.1 [ECO:0000345] ##Evidence-Data-END## uc033iwo.1 uc033iwo.2 
ENSMUST00000176921.4 Rab26os ENSMUST00000176921.4 Rab26os (from geneSymbol) AK011460 ENSMUST00000176921.1 ENSMUST00000176921.2 ENSMUST00000176921.3 uc008awt.1 uc008awt.2 uc008awt.3 uc008awt.4 uc008awt.5 uc008awt.6 uc008awt.1 uc008awt.2 uc008awt.3 uc008awt.4 uc008awt.5 uc008awt.6 
ENSMUST00000176923.9 Wdr90 ENSMUST00000176923.9 Required for efficient primary cilium formation. (from UniProt Q6ZPG2) AK154827 ENSMUST00000176923.1 ENSMUST00000176923.2 ENSMUST00000176923.3 ENSMUST00000176923.4 ENSMUST00000176923.5 ENSMUST00000176923.6 ENSMUST00000176923.7 ENSMUST00000176923.8 Kiaa1924 Q6ZPG2 Q80VI2 Q8BI97 Q8R3G7 Q921X4 WDR90_MOUSE uc289ilz.1 uc289ilz.2 uc289ilz.3 Required for efficient primary cilium formation. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6ZPG2-1; Sequence=Displayed; Name=2; IsoId=Q6ZPG2-2; Sequence=VSP_034309, VSP_034314; Name=3; IsoId=Q6ZPG2-3; Sequence=VSP_034310, VSP_034311, VSP_034312, VSP_034313; Belongs to the WD repeat WDR90/POC16 family. Sequence=AAH25468.1; Type=Erroneous initiation; Evidence=; cytoplasm centriole cytoskeleton microtubule binding cell projection organization cilium assembly uc289ilz.1 uc289ilz.2 uc289ilz.3 
ENSMUST00000176934.3 Gm10860 ENSMUST00000176934.3 Gm10860 (from geneSymbol) AK133440 ENSMUST00000176934.1 ENSMUST00000176934.2 uc288vhy.1 uc288vhy.2 uc288vhy.3 uc288vhy.1 uc288vhy.2 uc288vhy.3 
ENSMUST00000176935.8 Gm29394 ENSMUST00000176935.8 Gm29394 (from geneSymbol) AK142790 ENSMUST00000176935.1 ENSMUST00000176935.2 ENSMUST00000176935.3 ENSMUST00000176935.4 ENSMUST00000176935.5 ENSMUST00000176935.6 ENSMUST00000176935.7 Gm29394 H3BIW7 H3BIW7_MOUSE uc007vtc.1 uc007vtc.2 uc007vtc.3 uc007vtc.4 uc007vtc.1 uc007vtc.2 uc007vtc.3 uc007vtc.4 
ENSMUST00000176972.2 AU023070 ENSMUST00000176972.2 AU023070 (from geneSymbol) ENSMUST00000176972.1 uc290wfw.1 uc290wfw.2 uc290wfw.1 uc290wfw.2 
ENSMUST00000176978.8 Kcnip4 ENSMUST00000176978.8 Kv channel interacting protein 4, transcript variant 4 (from RefSeq NM_030265.3) Calp ENSMUST00000176978.1 ENSMUST00000176978.2 ENSMUST00000176978.3 ENSMUST00000176978.4 ENSMUST00000176978.5 ENSMUST00000176978.6 ENSMUST00000176978.7 KCIP4_MOUSE Kchip4 NM_030265 Q6DTJ3 Q6PHZ8 Q8CAD0 Q8R4I2 Q9EQ01 uc008xjw.1 uc008xjw.2 uc008xjw.3 Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3 (PubMed:19109250). Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Component of heteromultimeric potassium channels (PubMed:19713751, PubMed:20943905). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (PubMed:19713751). Interacts with the C-terminus of PSEN2 and probably PSEN1 (By similarity). Interacts with KCND2 and KCND3. Cell membrane ; Peripheral membrane protein Cytoplasm Peroxisome Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6PHZ8-1; Sequence=Displayed; Name=2; IsoId=Q6PHZ8-2; Sequence=VSP_015071; Name=3; IsoId=Q6PHZ8-3; Sequence=VSP_015069; Name=4; Synonyms=KChIPa; IsoId=Q6PHZ8-4; Sequence=VSP_015070; Expressed in brain. Highly expressed by neurons in layers II-IV of cortex and in hippocampus, thalamus and the Purkinje cell layer of the cerebellum. The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly inactivating delayed rectifier potassium current. Belongs to the recoverin family. voltage-gated ion channel activity potassium channel activity calcium ion binding cytoplasm cytosol plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex potassium channel regulator activity membrane dendrite regulation of ion transmembrane transport neuronal cell body metal ion binding potassium ion transmembrane transport protein localization to plasma membrane regulation of potassium ion transmembrane transport uc008xjw.1 uc008xjw.2 uc008xjw.3 
ENSMUST00000177005.8 Glmp ENSMUST00000177005.8 glycosylated lysosomal membrane protein (from RefSeq NM_020003.1) ENSMUST00000177005.1 ENSMUST00000177005.2 ENSMUST00000177005.3 ENSMUST00000177005.4 ENSMUST00000177005.5 ENSMUST00000177005.6 ENSMUST00000177005.7 GLMP_MOUSE Glmp NM_020003 Q3TUF5 Q3UBV7 Q8C6H7 Q9JHJ3 uc008pup.1 uc008pup.2 uc008pup.3 Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization. Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1. Lysosome membrane ingle-pass type I membrane protein ; Lumenal side Detected in brain, heart, liver, kidney, lung, intestine, testis and spleen (PubMed:11444019, PubMed:19489740, PubMed:24487409). Expressed at highest levels in kidney cortex (PubMed:11444019, PubMed:19489740). However, another study reports highest expression levels in lung (PubMed:24487409). Expressed in myoblasts with expression increasing during differentiation into myotubes (PubMed:26707125). Expressed throughout embryogenesis (PubMed:11444019). After birth, there is a rapid increase in expression within the first week of life, reaching adult levels by week 2 (PubMed:27141234). Highly N-glycosylated (PubMed:19489740, PubMed:19349973). N- glycosylation is essential for GLMP stability and for MFSD1 lysosomal localization (PubMed:32959924). Viable and fertile (PubMed:24487409). Significantly reduced levels of Mfsd1 (PubMed:31661432). Splenomegaly (PubMed:24487409, PubMed:26047317). Reduced size of epididymal fat pads (PubMed:26047317). Enlargement of liver and spontaneous development of liver fibrosis which is not present at birth but develops shortly after and reaches a peak at 4 months of age (PubMed:24487409, PubMed:26047317, PubMed:27141234). The liver phenotype is associated with increased expression of markers for inflammatory responses, apoptosis and oxidative stress (PubMed:24487409, PubMed:27141234). Livers show local foci where hepatocytes are lost and liver sinusoidal endothelial cells are replaced by ordinary capillary endothelium (PubMed:31661432). Reduced liver function (PubMed:27141234). Kupffer cells have increased accumulation of iron and lipofuscin (PubMed:24487409). Decreased blood glucose and serum lipids and increased liver triacylglycerol (PubMed:26047317). Altered liver expression of genes involved in metabolism including decreased expression of Acox1, Angptl4, Fabp1, Slc2a2/Glut2, Ppara, Plin2 and Plin5 and increased expression of Apoc3, Cd36, Fasn, Pdk4, Ppard, Pparg, Scd1 and Scd2 (PubMed:26047317). Increased liver expression of Pecam31/Cd31 and Vwf (PubMed:31661432). Increased glucose and fatty acid uptake in hepatocytes and increased glucose oxidation (PubMed:26047317). Increased de novo lipogenesis in hepatocytes (PubMed:26047317). Increased hepatocyte proliferation and oval cell mobilization up to 6 months of age (PubMed:27141234). Increased frequency of liver tumors after 12 months of age (PubMed:27141234). Anemia, thrombocytopenia, and reduced levels of white blood cells (PubMed:27141234). No effect on composition of muscle fibers but myotubes metabolize glucose faster and have a larger pool of intracellular glycogen while oleic acid uptake, storage and oxidation are significantly reduced (PubMed:26707125). Increased myotube expression of Myh2, Myh4 and Scd1 and decreased expression of Cd36, Myh7, Plin2, Ppara, Ppard, Pparg, Pgc1a and Scd2 (PubMed:26707125). Belongs to the GLMP family. transcription factor activity, sequence-specific DNA binding nucleus lysosome lysosomal membrane cytosol membrane integral component of membrane transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter uc008pup.1 uc008pup.2 uc008pup.3 
ENSMUST00000177012.8 Gm13381 ENSMUST00000177012.8 Gm13381 (from geneSymbol) ENSMUST00000177012.1 ENSMUST00000177012.2 ENSMUST00000177012.3 ENSMUST00000177012.4 ENSMUST00000177012.5 ENSMUST00000177012.6 ENSMUST00000177012.7 uc289ukm.1 uc289ukm.2 uc289ukm.1 uc289ukm.2 
ENSMUST00000177015.2 A730085K08Rik ENSMUST00000177015.2 A730085K08Rik (from geneSymbol) AK043328 ENSMUST00000177015.1 uc009sez.1 uc009sez.2 uc009sez.3 uc009sez.4 uc009sez.1 uc009sez.2 uc009sez.3 uc009sez.4 
ENSMUST00000177043.3 Prox2os ENSMUST00000177043.3 prospero homeobox 2 opposite strand (from RefSeq NR_189023.1) ENSMUST00000177043.1 ENSMUST00000177043.2 NR_189023 uc007ogg.1 uc007ogg.2 uc007ogg.3 uc007ogg.1 uc007ogg.2 uc007ogg.3 
ENSMUST00000177048.2 4931403E22Rik ENSMUST00000177048.2 RIKEN cDNA 4931403E22 gene (from RefSeq NR_045306.2) ENSMUST00000177048.1 NR_045306 uc029trw.1 uc029trw.2 uc029trw.1 uc029trw.2 
ENSMUST00000177059.2 Gm20658 ENSMUST00000177059.2 Gm20658 (from geneSymbol) AK080151 ENSMUST00000177059.1 uc007phg.1 uc007phg.2 uc007phg.1 uc007phg.2 
ENSMUST00000177068.8 Chtf8 ENSMUST00000177068.8 CTF8, chromosome transmission fidelity factor 8, transcript variant 1 (from RefSeq NM_145412.4) CTF8_MOUSE Chtf8 Ctf8 ENSMUST00000177068.1 ENSMUST00000177068.2 ENSMUST00000177068.3 ENSMUST00000177068.4 ENSMUST00000177068.5 ENSMUST00000177068.6 ENSMUST00000177068.7 NM_145412 P0C6T0 P0CG15 Q8BHM2 Q8R5A5 uc009ngp.1 uc009ngp.2 Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression (By similarity). Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. The CTF18-RFC complex interacts with POLH. CTF18/CTF8/DSCC1 associate with PCNA. CTF8 exists as a dimer with DSCC1 (By similarity). Nucleus Note=Associates with chromatin during S phase. Belongs to the CTF8 family. DNA binding DNA clamp loader activity nucleus DNA replication cell cycle mitotic sister chromatid cohesion single-stranded DNA-dependent ATP-dependent DNA helicase activity Ctf18 RFC-like complex DNA duplex unwinding positive regulation of DNA-directed DNA polymerase activity uc009ngp.1 uc009ngp.2 
ENSMUST00000177083.8 Asap1 ENSMUST00000177083.8 ArfGAP with SH3 domain, ankyrin repeat and PH domain1, transcript variant 4 (from RefSeq NM_001276463.2) Asap1 E9QMJ1 E9QMJ1_MOUSE ENSMUST00000177083.1 ENSMUST00000177083.2 ENSMUST00000177083.3 ENSMUST00000177083.4 ENSMUST00000177083.5 ENSMUST00000177083.6 ENSMUST00000177083.7 NM_001276463 uc007vzj.1 uc007vzj.2 uc007vzj.3 uc007vzj.4 GTPase activator activity positive regulation of GTPase activity metal ion binding uc007vzj.1 uc007vzj.2 uc007vzj.3 uc007vzj.4 
ENSMUST00000177097.3 Gm22871 ENSMUST00000177097.3 Gm22871 (from geneSymbol) ENSMUST00000177097.1 ENSMUST00000177097.2 uc287snc.1 uc287snc.2 uc287snc.1 uc287snc.2 
ENSMUST00000177104.2 Gm20609 ENSMUST00000177104.2 predicted gene 20609 (from RefSeq NR_152791.1) ENSMUST00000177104.1 NR_152791 uc007fop.1 uc007fop.2 uc007fop.1 uc007fop.2 
ENSMUST00000177111.8 Itgad ENSMUST00000177111.8 Membrane ingle-pass type I membrane protein (from UniProt H3BKX8) AK156218 ENSMUST00000177111.1 ENSMUST00000177111.2 ENSMUST00000177111.3 ENSMUST00000177111.4 ENSMUST00000177111.5 ENSMUST00000177111.6 ENSMUST00000177111.7 H3BKX8 H3BKX8_MOUSE Itgad uc291was.1 uc291was.2 Membrane ingle-pass type I membrane protein Belongs to the integrin alpha chain family. cell adhesion integrin-mediated signaling pathway integrin complex membrane integral component of membrane uc291was.1 uc291was.2 
ENSMUST00000177113.2 H2bc18 ENSMUST00000177113.2 H2B clustered histone 18 (from RefSeq NM_175666.3) ENSMUST00000177113.1 H2B2B_MOUSE Hist2h2bb NM_175666 Q64525 uc008qmp.1 uc008qmp.2 uc008qmp.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BB622628.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome DNA binding nucleus nucleoplasm chromosome cytosol nucleosome assembly protein heterodimerization activity uc008qmp.1 uc008qmp.2 uc008qmp.3 
ENSMUST00000177130.8 4932443L11Rik ENSMUST00000177130.8 4932443L11Rik (from geneSymbol) AK019856 ENSMUST00000177130.1 ENSMUST00000177130.2 ENSMUST00000177130.3 ENSMUST00000177130.4 ENSMUST00000177130.5 ENSMUST00000177130.6 ENSMUST00000177130.7 uc291xwa.1 uc291xwa.2 uc291xwa.1 uc291xwa.2 
ENSMUST00000177146.2 Gm26939 ENSMUST00000177146.2 vomeronasal 2, receptor, pseudogene 11 (from RefSeq NR_003962.1) ENSMUST00000177146.1 NR_003962 uc008pkg.1 uc008pkg.2 uc008pkg.3 uc008pkg.4 uc008pkg.1 uc008pkg.2 uc008pkg.3 uc008pkg.4 
ENSMUST00000177151.9 Vmn2r2 ENSMUST00000177151.9 vomeronasal 2, receptor 2 (from RefSeq NM_001385025.1) ENSMUST00000177151.1 ENSMUST00000177151.2 ENSMUST00000177151.3 ENSMUST00000177151.4 ENSMUST00000177151.5 ENSMUST00000177151.6 ENSMUST00000177151.7 ENSMUST00000177151.8 L7N2E9 L7N2E9_MOUSE NM_001385025 Vmn2r2 uc290fql.1 uc290fql.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc290fql.1 uc290fql.2 
ENSMUST00000177155.8 Brd10 ENSMUST00000177155.8 Brd10 (from geneSymbol) 9930021J03Rik BC023491 ENSMUST00000177155.1 ENSMUST00000177155.2 ENSMUST00000177155.3 ENSMUST00000177155.4 ENSMUST00000177155.5 ENSMUST00000177155.6 ENSMUST00000177155.7 H3BKP8 H3BKP8_MOUSE uc289rpz.1 uc289rpz.2 molecular_function cellular_component biological_process uc289rpz.1 uc289rpz.2 
ENSMUST00000177173.8 Cdhr4 ENSMUST00000177173.8 cadherin-related family member 4 (from RefSeq NM_001378391.1) Cdhr4 ENSMUST00000177173.1 ENSMUST00000177173.2 ENSMUST00000177173.3 ENSMUST00000177173.4 ENSMUST00000177173.5 ENSMUST00000177173.6 ENSMUST00000177173.7 H3BJZ2 H3BJZ2_MOUSE NM_001378391 uc029xgc.1 uc029xgc.2 uc029xgc.3 molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc029xgc.1 uc029xgc.2 uc029xgc.3 
ENSMUST00000177184.9 Vmn2r5 ENSMUST00000177184.9 vomeronasal 2, receptor 5 (from RefSeq NM_001385126.1) ENSMUST00000177184.1 ENSMUST00000177184.2 ENSMUST00000177184.3 ENSMUST00000177184.4 ENSMUST00000177184.5 ENSMUST00000177184.6 ENSMUST00000177184.7 ENSMUST00000177184.8 K7N788 K7N788_MOUSE NM_001385126 Vmn2r5 uc290frh.1 uc290frh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc290frh.1 uc290frh.2 
ENSMUST00000177185.2 Gm20642 ENSMUST00000177185.2 Gm20642 (from geneSymbol) AK133078 ENSMUST00000177185.1 uc007tcb.1 uc007tcb.2 uc007tcb.1 uc007tcb.2 
ENSMUST00000177205.2 Zfp428 ENSMUST00000177205.2 zinc finger protein 428, transcript variant 2 (from RefSeq NM_175142.1) ENSMUST00000177205.1 H3BLD9 H3BLD9_MOUSE NM_175142 Zfp428 uc009fpt.1 uc009fpt.2 uc009fpt.3 uc009fpt.4 uc009fpt.5 nucleic acid binding uc009fpt.1 uc009fpt.2 uc009fpt.3 uc009fpt.4 uc009fpt.5 
ENSMUST00000177209.3 Gm22394 ENSMUST00000177209.3 Gm22394 (from geneSymbol) ENSMUST00000177209.1 ENSMUST00000177209.2 uc287snb.1 uc287snb.2 uc287snb.1 uc287snb.2 
ENSMUST00000177211.2 Higd1c ENSMUST00000177211.2 HIG1 domain family, member 1C (from RefSeq NM_001002900.1) ENSMUST00000177211.1 Gm921 HIG1C_MOUSE Hig1-4 NM_001002900 Q76I25 Ubie uc007xrb.1 uc007xrb.2 uc007xrb.3 Membrane ; Multi-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc007xrb.1 uc007xrb.2 uc007xrb.3 
ENSMUST00000177217.3 Mir5616 ENSMUST00000177217.3 microRNA 5616 (from RefSeq NR_049189.1) ENSMUST00000177217.1 ENSMUST00000177217.2 NR_049189 uc033igv.1 uc033igv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611586.1 [ECO:0000345] ##Evidence-Data-END## uc033igv.1 uc033igv.2 
ENSMUST00000177236.8 Rnf141 ENSMUST00000177236.8 ring finger protein 141, transcript variant 16 (from RefSeq NR_184821.1) ENSMUST00000177236.1 ENSMUST00000177236.2 ENSMUST00000177236.3 ENSMUST00000177236.4 ENSMUST00000177236.5 ENSMUST00000177236.6 ENSMUST00000177236.7 NR_184821 Q99MB7 Q9D040 Q9D5C4 Q9D9L0 RN141_MOUSE Znf230 uc009jfq.1 uc009jfq.2 uc009jfq.3 May be involved in spermatogenesis. Membrane ; Lipid- anchor Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99MB7-1; Sequence=Displayed; Name=2; IsoId=Q99MB7-2; Sequence=Not described; Name=3; IsoId=Q99MB7-3; Sequence=Not described; Isoform 1 is testis-specific. Isoform 2 is expressed in heart, brain, skeletal muscle, kidney, pancreas, lung, liver and testis. Isoform 3 is expressed in heart, liver, and kidney. Expression was first detected at postnatal day 6, and reached the adult level between postnatal day 14 and 21. DNA binding ubiquitin-protein transferase activity cellular_component regulation of transcription, DNA-templated membrane metal ion binding protein autoubiquitination uc009jfq.1 uc009jfq.2 uc009jfq.3 
ENSMUST00000177238.3 Mir5627 ENSMUST00000177238.3 microRNA 5627 (from RefSeq NR_049203.1) ENSMUST00000177238.1 ENSMUST00000177238.2 NR_049203 uc033gdl.1 uc033gdl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611598.1 [ECO:0000345] ##Evidence-Data-END## uc033gdl.1 uc033gdl.2 
ENSMUST00000177239.3 Gm20631 ENSMUST00000177239.3 Gm20631 (from geneSymbol) AK144160 ENSMUST00000177239.1 ENSMUST00000177239.2 uc287mmj.1 uc287mmj.2 uc287mmj.1 uc287mmj.2 
ENSMUST00000177244.4 Vmn2r96 ENSMUST00000177244.4 vomeronasal 2, receptor 96 (from RefSeq NM_001385081.1) E9PZU5 E9PZU5_MOUSE ENSMUST00000177244.1 ENSMUST00000177244.2 ENSMUST00000177244.3 NM_001385081 Vmn2r96 uc289hkg.1 uc289hkg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc289hkg.1 uc289hkg.2 
ENSMUST00000177251.2 Gm20692 ENSMUST00000177251.2 Gm20692 (from geneSymbol) ENSMUST00000177251.1 uc291iki.1 uc291iki.2 uc291iki.1 uc291iki.2 
ENSMUST00000177258.3 Mterf1b ENSMUST00000177258.3 mitochondrial transcription termination factor 1b (from RefSeq NM_001042670.2) B9EJ57 ENSMUST00000177258.1 ENSMUST00000177258.2 Gm9897 L7N482 MTF1B_MOUSE Mterf Mterf1 Mterf1b NM_001042670 uc008wif.1 uc008wif.2 uc008wif.3 Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand. Monomer. Mitochondrion Expressed strongly in the heart and at lower levels in brain, liver and kidney. Contains nine structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a left-handed superhelical assembly with a solenoid structure that wraps itself around DNA (By similarity). Phosphoprotein with mostly four phosphate groups. While the DNA- binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation (By similarity). Double knockout of Mterf1a and Mterf1b results in viable animals with no gross phenotype, and normal oxidative phosphorylation capacity. Steady-state mitochondrial DNA levels are normal. There are subtle effects on levels of mitochondrial transcripts: transcripts initiated at the light strand promoter and also situated downstream of the MTERF binding site are increased, levels of 7S RNA are reduced, while levels of other mitochondrial transcripts appear normal. Belongs to the mTERF family. DNA binding double-stranded DNA binding mitochondrion cytosol DNA-templated transcription, termination regulation of transcription, DNA-templated transcription initiation from mitochondrial promoter termination of mitochondrial transcription mitochondrial nucleoid sequence-specific DNA binding uc008wif.1 uc008wif.2 uc008wif.3 
ENSMUST00000177284.2 Gm20643 ENSMUST00000177284.2 Gm20643 (from geneSymbol) ENSMUST00000177284.1 uc292kko.1 uc292kko.2 uc292kko.1 uc292kko.2 
ENSMUST00000177292.8 Nptn ENSMUST00000177292.8 neuroplastin, transcript variant 5 (from RefSeq NM_001406062.1) ENSMUST00000177292.1 ENSMUST00000177292.2 ENSMUST00000177292.3 ENSMUST00000177292.4 ENSMUST00000177292.5 ENSMUST00000177292.6 ENSMUST00000177292.7 NM_001406062 NPTN_MOUSE P97300 Q3U519 Q8C637 Q8C6H8 Sdfr1 Sdr1 uc292hte.1 uc292hte.2 Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane (By similarity). Interacts with ATP2B1; this interaction stabilizes ATP2B1 and increases ATPase activity; this interaction controls T cell calcium homeostasis following T cell activation (PubMed:28827723). Interacts with XKR8; promoting its localization at the cell membrane (By similarity). Cell membrane ; Single-pass type I membrane protein [Isoform 2]: Postsynaptic density Event=Alternative splicing; Named isoforms=4; Name=2; Synonyms=SDR-1beta; IsoId=P97300-2; Sequence=Displayed; Name=1; Synonyms=SDR-1alpha; IsoId=P97300-1; Sequence=VSP_039255; Name=3; IsoId=P97300-3; Sequence=VSP_039255, VSP_039257; Name=4; IsoId=P97300-4; Sequence=VSP_039254, VSP_039256; Isoform 1 and isoform 2 are widely expressed with variable levels in brain. Isoform 1 is expressed in cerebellum and midbrain. Isoform 1 and isoform 2 are expressed in cerebral cortex, hippocampus and striatum. Isoform 2 is more abundant in the cerebral cortex than isoform 1. Some isoforms lack the first Ig-like domain which may confer homophilic adhesion activity. However, they can bind and activate FGFR1 (By similarity). N-glycosylated. immunological synapse negative regulation of cytokine production positive regulation of protein phosphorylation type 1 fibroblast growth factor receptor binding protein binding plasma membrane cellular calcium ion homeostasis cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules positive regulation of cytosolic calcium ion concentration nervous system development axon guidance positive regulation of neuron projection development membrane integral component of membrane axon dendrite presynaptic membrane positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of long-term neuronal synaptic plasticity modulation of synaptic transmission synapse organization cell adhesion molecule binding long-term synaptic potentiation dendrite self-avoidance protein binding involved in cell-cell adhesion regulation of receptor localization to synapse excitatory synapse assembly uc292hte.1 uc292hte.2 
ENSMUST00000177304.8 Pyy ENSMUST00000177304.8 peptide YY, transcript variant 2 (from RefSeq NM_001346771.1) ENSMUST00000177304.1 ENSMUST00000177304.2 ENSMUST00000177304.3 ENSMUST00000177304.4 ENSMUST00000177304.5 ENSMUST00000177304.6 ENSMUST00000177304.7 H3BK86 H3BK86_MOUSE NM_001346771 Pyy uc057kmm.1 uc057kmm.2 uc057kmm.3 This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. Secreted Belongs to the NPY family. G-protein coupled receptor binding hormone activity extracellular region signal transduction uc057kmm.1 uc057kmm.2 uc057kmm.3 
ENSMUST00000177314.2 Gm20652 ENSMUST00000177314.2 Gm20652 (from geneSymbol) ENSMUST00000177314.1 uc290gpm.1 uc290gpm.2 uc290gpm.1 uc290gpm.2 
ENSMUST00000177323.8 1700037C18Rik ENSMUST00000177323.8 1700037C18Rik (from geneSymbol) 1700037C18Rik AK161085 ENSMUST00000177323.1 ENSMUST00000177323.2 ENSMUST00000177323.3 ENSMUST00000177323.4 ENSMUST00000177323.5 ENSMUST00000177323.6 ENSMUST00000177323.7 H3BLF4 H3BLF4_MOUSE uc289cah.1 uc289cah.2 uc289cah.1 uc289cah.2 
ENSMUST00000177331.2 Gm23090 ENSMUST00000177331.2 Gm23090 (from geneSymbol) ENSMUST00000177331.1 LF194338 uc290lwx.1 uc290lwx.2 uc290lwx.1 uc290lwx.2 
ENSMUST00000177351.3 Gm20711 ENSMUST00000177351.3 Gm20711 (from geneSymbol) ENSMUST00000177351.1 ENSMUST00000177351.2 uc287nok.1 uc287nok.2 uc287nok.1 uc287nok.2 
ENSMUST00000177359.2 Tmem276 ENSMUST00000177359.2 transmembrane protein 276, transcript variant 15 (from RefSeq NM_001408089.1) ENSMUST00000177359.1 NM_001408089 P0DW86 Q6P6J7 Q6ZQA2 Q9D134 Q9QXA1 TM276_MOUSE Tmem276 uc007wlj.1 uc007wlj.2 uc007wlj.3 uc007wlj.4 Membrane ; Multi-pass membrane protein uc007wlj.1 uc007wlj.2 uc007wlj.3 uc007wlj.4 
ENSMUST00000177363.2 Gm20628 ENSMUST00000177363.2 Gm20628 (from geneSymbol) AK134918 ENSMUST00000177363.1 uc290htv.1 uc290htv.2 uc290htv.1 uc290htv.2 
ENSMUST00000177368.2 Gm20661 ENSMUST00000177368.2 Gm20661 (from geneSymbol) BC115539 ENSMUST00000177368.1 Gm20661 K7N787 K7N787_MOUSE uc292lab.1 uc292lab.2 uc292lab.1 uc292lab.2 
ENSMUST00000177375.2 Gm52993 ENSMUST00000177375.2 Gm52993 (from geneSymbol) AK145594 CS084_MOUSE ENSMUST00000177375.1 Gm38999 Gm52993 H3BKT1 uc291ozj.1 uc291ozj.2 uc291ozj.1 uc291ozj.2 
ENSMUST00000177390.8 Golph3l ENSMUST00000177390.8 golgi phosphoprotein 3-like, transcript variant 11 (from RefSeq NR_175821.1) ENSMUST00000177390.1 ENSMUST00000177390.2 ENSMUST00000177390.3 ENSMUST00000177390.4 ENSMUST00000177390.5 ENSMUST00000177390.6 ENSMUST00000177390.7 GLP3L_MOUSE NR_175821 Q3TIX2 Q3TV24 Q8R088 uc008qkg.1 uc008qkg.2 uc008qkg.3 uc008qkg.4 Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. Homooligomer. Does not interact MYO18; differs from GOLPH3 by its inability to interact with MYO18. May interact with ARF1 (By similarity). Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Phosphatidylinositol 4-phosphate (PtdIns4P)- binding mediates recruitment to Golgi membranes. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R088-1; Sequence=Displayed; Name=2; IsoId=Q8R088-2; Sequence=VSP_032151; Name=3; IsoId=Q8R088-3; Sequence=VSP_032152; Expressed in a subset of tissues tested with higher expression in salivary gland, small intestine and skin (at protein level). Belongs to the GOLPH3/VPS74 family. Golgi apparatus trans-Golgi network cytosol retrograde vesicle-mediated transport, Golgi to ER Golgi organization lipid binding membrane Golgi cisterna Golgi cisterna membrane Golgi to plasma membrane protein transport Golgi vesicle budding positive regulation of protein secretion phosphatidylinositol-4-phosphate binding uc008qkg.1 uc008qkg.2 uc008qkg.3 uc008qkg.4 
ENSMUST00000177403.2 Ppp1r3e ENSMUST00000177403.2 Ppp1r3e (from geneSymbol) AK131886 ENSMUST00000177403.1 H3BJB2 H3BJB2_MOUSE Ppp1r3e uc288uii.1 uc288uii.2 uc288uii.1 uc288uii.2 
ENSMUST00000177434.3 Lekr1 ENSMUST00000177434.3 leucine, glutamate and lysine rich 1, transcript variant 1 (from RefSeq NM_001166659.1) A0A571BF98 A0A571BF98_MOUSE ENSMUST00000177434.1 ENSMUST00000177434.2 Lekr1 NM_001166659 uc290fsp.1 uc290fsp.2 uc290fsp.3 uc290fsp.1 uc290fsp.2 uc290fsp.3 
ENSMUST00000177442.2 Bola1 ENSMUST00000177442.2 Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5. May protect cells against oxidative stress (By similarity). (from UniProt Q9D8S9) AK007718 BOLA1_MOUSE ENSMUST00000177442.1 Q9D8S9 uc290hti.1 uc290hti.2 Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5. May protect cells against oxidative stress (By similarity). Interacts with GLRX5. Mitochondrion Belongs to the BolA/IbaG family. molecular_function mitochondrion transcription, DNA-templated uc290hti.1 uc290hti.2 
ENSMUST00000177461.3 Snora15 ENSMUST00000177461.3 small nucleolar RNA, H/ACA box 15 (from RefSeq NR_003681.1) ENSMUST00000177461.1 ENSMUST00000177461.2 NR_003681 uc008ztj.1 uc008ztj.2 uc008ztj.3 uc008ztj.1 uc008ztj.2 uc008ztj.3 
ENSMUST00000177479.2 Ly6l ENSMUST00000177479.2 lymphocyte antigen 6 family member L (from RefSeq NM_001347049.1) ENSMUST00000177479.1 Gm20654 H3BJG9 LY6L_MOUSE Ly6l NM_001347049 uc057kuc.1 uc057kuc.2 uc057kuc.3 Cell membrane ; Lipid-anchor, GPI- anchor plasma membrane membrane anchored component of membrane uc057kuc.1 uc057kuc.2 uc057kuc.3 
ENSMUST00000177481.4 Vmn2r127 ENSMUST00000177481.4 Vmn2r127 (from geneSymbol) A0A3Q4L333 A0A3Q4L333_MOUSE ENSMUST00000177481.1 ENSMUST00000177481.2 ENSMUST00000177481.3 Vmn2r127 uc289hkp.1 uc289hkp.2 G-protein coupled receptor activity G-protein coupled receptor signaling pathway membrane integral component of membrane uc289hkp.1 uc289hkp.2 
ENSMUST00000177523.8 Prh1 ENSMUST00000177523.8 proline rich protein HaeIII subfamily 1 (from RefSeq NM_011174.4) D3Z1V5 D3Z1V5_MOUSE ENSMUST00000177523.1 ENSMUST00000177523.2 ENSMUST00000177523.3 ENSMUST00000177523.4 ENSMUST00000177523.5 ENSMUST00000177523.6 ENSMUST00000177523.7 H3BLQ6 NM_011174 Prh1 Prp2 uc291joq.1 uc291joq.2 This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an important dental function by protecting mice against toxic dietary polyphenols such as tannins and influence the visco-elastic properties of the mucus. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 6. [provided by RefSeq, Nov 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## uc291joq.1 uc291joq.2 
ENSMUST00000177530.8 Zfp169 ENSMUST00000177530.8 zinc finger protein 169, transcript variant 1 (from RefSeq NM_026450.3) E9Q3R6 E9Q3R6_MOUSE ENSMUST00000177530.1 ENSMUST00000177530.2 ENSMUST00000177530.3 ENSMUST00000177530.4 ENSMUST00000177530.5 ENSMUST00000177530.6 ENSMUST00000177530.7 NM_026450 Zfp169 uc007qig.1 uc007qig.2 uc007qig.3 uc007qig.4 uc007qig.5 molecular_function nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc007qig.1 uc007qig.2 uc007qig.3 uc007qig.4 uc007qig.5 
ENSMUST00000177545.2 Gm20605 ENSMUST00000177545.2 predicted gene 20605 (from RefSeq NR_033148.1) ENSMUST00000177545.1 H3BLL3 LRCH4_MOUSE Lrch4 NR_033148 Q921G6 uc291axz.1 uc291axz.2 This locus represents naturally occurring readthrough transcription between the neighboring Lrch4 (leucine-rich repeats and calponin homology (CH) domain containing 4) and Sap25 (sin3 associated polypeptide) genes on chromosome 5. The readthrough transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, May 2013]. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. ##Evidence-Data-START## Transcript exon combination :: AK158025.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 231798, 751865 ##RefSeq-Attributes-END## Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. Cell membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q921G6-1; Sequence=Displayed; Name=2; IsoId=Q921G6-2; Sequence=VSP_061971, VSP_061972; Widely expressed across tissues, with the most abundant expression in spleen, testes, thymus, intestine, and blood (PubMed:30523158). Expressed in macrophages (PubMed:30523158). Expression is inhibited by LPS. protein binding cytoplasm PML body negative regulation of transcription, DNA-templated uc291axz.1 uc291axz.2 
ENSMUST00000177549.8 Kcnk13 ENSMUST00000177549.8 potassium channel, subfamily K, member 13, transcript variant 2 (from RefSeq NM_001164426.1) ENSMUST00000177549.1 ENSMUST00000177549.2 ENSMUST00000177549.3 ENSMUST00000177549.4 ENSMUST00000177549.5 ENSMUST00000177549.6 ENSMUST00000177549.7 Gm1570 KCNKD_MOUSE NM_001164426 Q8R1P5 uc007osl.1 uc007osl.2 uc007osl.3 Potassium channel displaying weak inward rectification in symmetrical K(+) solution. Homodimer. Membrane ; Multi-pass membrane protein The current is enhanced by arachidonic acid and inhibited by halothane. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. voltage-gated ion channel activity potassium channel activity integral component of plasma membrane ion transport potassium ion transport membrane integral component of membrane potassium ion leak channel activity stabilization of membrane potential regulation of ion transmembrane transport potassium ion transmembrane transport uc007osl.1 uc007osl.2 uc007osl.3 
ENSMUST00000177551.2 Nlrc3 ENSMUST00000177551.2 NLR family, CARD domain containing 3, transcript variant 1 (from RefSeq NM_001081280.2) ENSMUST00000177551.1 J3QQ49 J3QQ49_MOUSE NM_001081280 Nlrc3 uc007xzc.1 uc007xzc.2 uc007xzc.3 Cytoplasm nucleotide binding ATP binding cytoplasm microtubule organizing center cytosol I-kappaB kinase/NF-kappaB signaling negative regulation of NF-kappaB transcription factor activity negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production T cell activation negative regulation of I-kappaB kinase/NF-kappaB signaling perinuclear region of cytoplasm negative regulation of inflammatory response negative regulation of NLRP3 inflammasome complex assembly negative regulation of NIK/NF-kappaB signaling uc007xzc.1 uc007xzc.2 uc007xzc.3 
ENSMUST00000177562.2 ENSMUSG00000095092 ENSMUST00000177562.2 ENSMUSG00000095092 (from geneSymbol) AK139759 ENSMUST00000177562.1 uc289soy.1 uc289soy.2 uc289soy.1 uc289soy.2 
ENSMUST00000177563.2 Gng14 ENSMUST00000177563.2 G protein subunit gamma 14 (from RefSeq NM_001195531.2) B2RVA4 B2RVA4_MOUSE EG436049 ENSMUST00000177563.1 Gm5741 Gng14 NM_001195531 uc012ghp.1 uc012ghp.2 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units; alpha, beta and gamma. Cell membrane ipid-anchor ; Cytoplasmic side mbrane ; Lipid-anchor ; Cytoplasmic side Belongs to the G protein gamma family. GTPase activity heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane G-protein beta/gamma-subunit complex G-protein beta-subunit binding uc012ghp.1 uc012ghp.2 
ENSMUST00000177564.2 Trdd2 ENSMUST00000177564.2 Trdd2 (from geneSymbol) ENSMUST00000177564.1 uc288ubx.1 uc288ubx.2 uc288ubx.1 uc288ubx.2 
ENSMUST00000177567.8 Slc38a3 ENSMUST00000177567.8 solute carrier family 38, member 3, transcript variant 3 (from RefSeq NM_001199218.1) ENSMUST00000177567.1 ENSMUST00000177567.2 ENSMUST00000177567.3 ENSMUST00000177567.4 ENSMUST00000177567.5 ENSMUST00000177567.6 ENSMUST00000177567.7 NM_001199218 Q8BS53 Q9DCP2 Q9JLL8 S38A3_MOUSE Slc38a3 Sn1 Snat3 uc009rmq.1 uc009rmq.2 uc009rmq.3 uc009rmq.4 Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:30017230, PubMed:18689705, PubMed:29561757, PubMed:15899884, PubMed:16249471, PubMed:10716701). Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (PubMed:30017230, PubMed:29561757, PubMed:18689705). The transport activity is specific for L-glutamine, L-histidine and L-asparagine (PubMed:16249471, PubMed:10716701, PubMed:15899884, PubMed:18689705, PubMed:29561757, PubMed:30017230). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:16249471, PubMed:10716701, PubMed:18689705). Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (PubMed:26490457). Reaction=H(+)(in) + L-histidine(out) + Na(+)(out) = H(+)(out) + L- histidine(in) + Na(+)(in); Xref=Rhea:RHEA:71135, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:57595; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71136; Evidence= PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71137; Evidence=; Reaction=H(+)(in) + L-glutamine(out) + Na(+)(out) = H(+)(out) + L- glutamine(in) + Na(+)(in); Xref=Rhea:RHEA:71127, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:58359; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71128; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71129; Evidence=; Reaction=H(+)(in) + L-asparagine(out) + Na(+)(out) = H(+)(out) + L- asparagine(in) + Na(+)(in); Xref=Rhea:RHEA:71131, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:58048; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71132; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71133; Evidence=; Kinetic parameters: KM=1.1 mM for L-histidine (in Na(+)-buffer at pH 7.5) ; KM=1.55 mM for L-glutamine (in Na(+)-buffer at pH 7.5) ; KM=0.41 mM for L-glutamine ; Cell membrane ulti-pass membrane protein Basolateral cell membrane Note=The localization appears to be basolateral in the plasma membrane of hepatocytes surrounding the central vein (PubMed:10716701). Localized at the cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelial cells (PubMed:32046769). In astrocytes, the localization at cell membrane is decreased by ammonia through the PKC signaling (PubMed:30017230). Expressed in both luminal and abluminal plasma membranes of larger microvessels and blood brain barrier (BBB) capillaries (PubMed:21364602). Restricted to the basolateral membranes of S3 segment cells of the proximal tubules (By similarity). Expressed predominantly in liver, moderately expressed in kidney and brain, and barely detectable in heart and muscle (PubMed:10716701). Within liver, expressed in hepatocytes (PubMed:10716701). Not detected in testis (PubMed:10716701). Expressed in cells of the ganglion cell layer, in soma of some cells of the inner nuclear layer (at protein level) (PubMed:18689705). Expressed in the inner segments of photoreceptor cells (PubMed:18689705). Up-regulated during renal ammoniagenesis and urinary ammonium excretion (PubMed:19458124). Up-regulated during acute acidosis (PubMed:24854847). Down-regulated by chronic treatment by insulin in hepatocytes (PubMed:15899884). Up-regulated by acute treatment by insulin (PubMed:15899884). Belongs to the amino acid/polyamine transporter 2 family. Fei et al (PMID:10823827) shows that the transport process is electrogenic with a Na(+):L-glutamine stoichiometry of 2:1, contrary to the conclusions of Chaudhry et al (PMID:10619430) who finds that the transport is electroneutral with a Na(+):L-glutamine stoichiometry of 1:1 (By similarity). Chaudhry et al (PMID:11742981) shows that this electrogenic transport describes by Fei et al (PMID:10823827) would correspond to an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). amino acid transmembrane transport L-histidine transmembrane transporter activity plasma membrane integral component of plasma membrane ion transport sodium ion transport amino acid transport asparagine transport glutamine transport brain development female pregnancy amino acid transmembrane transporter activity L-alanine transmembrane transporter activity L-asparagine transmembrane transporter activity L-glutamine transmembrane transporter activity symporter activity antiporter activity L-alanine transport histidine transport membrane integral component of membrane basolateral plasma membrane cellular response to potassium ion starvation positive regulation of transcription from RNA polymerase II promoter in response to acidic pH L-histidine transmembrane transport positive regulation of glutamine transport uc009rmq.1 uc009rmq.2 uc009rmq.3 uc009rmq.4 
ENSMUST00000177574.2 Esp3 ENSMUST00000177574.2 exocrine gland secreted peptide 3 (from RefSeq NM_001251916.1) ENSMUST00000177574.1 Esp3 J3QN49 J3QN49_MOUSE NM_001251916 uc029thw.1 uc029thw.2 pheromone activity extracellular space biological_process membrane integral component of membrane uc029thw.1 uc029thw.2 
ENSMUST00000177582.2 ENSMUSG00000094474 ENSMUST00000177582.2 ENSMUSG00000094474 (from geneSymbol) BC099967 ENSMUST00000177582.1 uc291cfm.1 uc291cfm.2 uc291cfm.1 uc291cfm.2 
ENSMUST00000177587.9 Jdp2 ENSMUST00000177587.9 Jun dimerization protein 2, transcript variant 2 (from RefSeq NM_001205052.2) ENSMUST00000177587.1 ENSMUST00000177587.2 ENSMUST00000177587.3 ENSMUST00000177587.4 ENSMUST00000177587.5 ENSMUST00000177587.6 ENSMUST00000177587.7 ENSMUST00000177587.8 JDP2_MOUSE Jundm2 NM_001205052 P97875 uc007ohb.1 uc007ohb.2 uc007ohb.3 Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV- induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin (By similarity). Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer. Interacts with IRF2BP1 (By similarity). Nucleus Ubiquitously expressed in all adult tissues tested as well in embryos. Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments. Polyubiquitinated; probably by IRF2BP1. Belongs to the bZIP family. ATF subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter regulation of histone deacetylation positive regulation of histone deacetylation negative regulation of fat cell differentiation protein heterodimerization activity uc007ohb.1 uc007ohb.2 uc007ohb.3 
ENSMUST00000177588.10 Lig1 ENSMUST00000177588.10 ligase I, DNA, ATP-dependent, transcript variant 3 (from RefSeq NM_001199310.2) ENSMUST00000177588.1 ENSMUST00000177588.2 ENSMUST00000177588.3 ENSMUST00000177588.4 ENSMUST00000177588.5 ENSMUST00000177588.6 ENSMUST00000177588.7 ENSMUST00000177588.8 ENSMUST00000177588.9 Lig1 NM_001199310 Q8R055 Q8R055_MOUSE uc012ezl.1 uc012ezl.2 uc012ezl.3 Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.; EC=6.5.1.1; Evidence= Belongs to the ATP-dependent DNA ligase family. nucleotide binding DNA binding DNA ligase activity DNA ligase (ATP) activity ATP binding DNA replication DNA repair DNA recombination cellular response to DNA damage stimulus ligase activity DNA ligation involved in DNA repair DNA biosynthetic process uc012ezl.1 uc012ezl.2 uc012ezl.3 
ENSMUST00000177594.8 Elmod2 ENSMUST00000177594.8 ELMO/CED-12 domain containing 2, transcript variant 1 (from RefSeq NM_178736.5) ELMD2_MOUSE ENSMUST00000177594.1 ENSMUST00000177594.2 ENSMUST00000177594.3 ENSMUST00000177594.4 ENSMUST00000177594.5 ENSMUST00000177594.6 ENSMUST00000177594.7 NM_178736 Q6AXC7 Q8BGF6 Q8BHP5 uc009mka.1 uc009mka.2 uc009mka.3 Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. GTPase activator activity positive regulation of GTPase activity regulation of defense response to virus uc009mka.1 uc009mka.2 uc009mka.3 
ENSMUST00000177595.9 Fut8 ENSMUST00000177595.9 fucosyltransferase 8, transcript variant 2 (from RefSeq NM_001252614.1) ENSMUST00000177595.1 ENSMUST00000177595.2 ENSMUST00000177595.3 ENSMUST00000177595.4 ENSMUST00000177595.5 ENSMUST00000177595.6 ENSMUST00000177595.7 ENSMUST00000177595.8 FUT8_MOUSE NM_001252614 Q543F5 Q921U1 Q9WTS2 uc007nyy.1 uc007nyy.2 uc007nyy.3 uc007nyy.4 Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Reaction=GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man- (1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc- (1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- [alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]; Xref=Rhea:RHEA:12985, Rhea:RHEA-COMP:13526, Rhea:RHEA-COMP:13532, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:60651, ChEBI:CHEBI:137207; EC=2.4.1.68; Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Note=Membrane-bound form in trans cisternae of Golgi. Tyrosine phosphorylated by PKDCC/VLK. Belongs to the glycosyltransferase 23 family. Name=Functional Glycomics Gateway - GTase; Note=Fucosyltransferase 8; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_615"; Golgi apparatus cytosol protein glycosylation protein N-linked glycosylation N-glycan processing transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway respiratory gaseous exchange glycoprotein 6-alpha-L-fucosyltransferase activity regulation of gene expression membrane integral component of membrane cell migration transferase activity transferase activity, transferring glycosyl groups SH3 domain binding protein N-linked glycosylation via asparagine Golgi cisterna membrane protein glycosylation in Golgi N-glycan fucosylation receptor metabolic process GDP-L-fucose metabolic process alpha-(1->6)-fucosyltransferase activity regulation of cellular response to oxidative stress uc007nyy.1 uc007nyy.2 uc007nyy.3 uc007nyy.4 
ENSMUST00000177604.2 Ska1 ENSMUST00000177604.2 spindle and kinetochore associated complex subunit 1, transcript variant 2 (from RefSeq NM_001164355.1) A0A0R4J0M5 A0A0R4J0M5_MOUSE ENSMUST00000177604.1 NM_001164355 Ska1 uc008fpf.1 uc008fpf.2 uc008fpf.3 Chromosome, centromere, kinetochore Belongs to the SKA1 family. mitotic cell cycle condensed chromosome outer kinetochore spindle microtubule chromosome segregation microtubule binding microtubule cytoskeleton regulation of microtubule polymerization or depolymerization cell division uc008fpf.1 uc008fpf.2 uc008fpf.3 
ENSMUST00000177608.8 Sulf1 ENSMUST00000177608.8 sulfatase 1, transcript variant 1 (from RefSeq NM_001198565.2) ENSMUST00000177608.1 ENSMUST00000177608.2 ENSMUST00000177608.3 ENSMUST00000177608.4 ENSMUST00000177608.5 ENSMUST00000177608.6 ENSMUST00000177608.7 Kiaa1077 NM_001198565 Q6ZPZ0 Q8BLJ0 Q8C1D3 Q8K007 SULF1_MOUSE uc007aia.1 uc007aia.2 uc007aia.3 uc007aia.4 Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (By similarity). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (By similarity). Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (By similarity). Reaction=an aryl sulfate + H2O = a phenol + H(+) + sulfate; Xref=Rhea:RHEA:17261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:33853, ChEBI:CHEBI:140317; EC=3.1.6.1; Evidence=; Reaction=Hydrolysis of the 6-sulfate groups of the N-acetyl-D- glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.; EC=3.1.6.14; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Endoplasmic reticulum Golgi apparatus, Golgi stack Cell surface [Extracellular sulfatase Sulf-2 secreted form]: Secreted Processing by furin produces a secreted form. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. Belongs to the sulfatase family. Sequence=BAC32179.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAC98088.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC98088.1; Type=Miscellaneous discrepancy; Note=Intron retention. The sequence is a pre-RNA and intronic sequences remain.; Evidence=; cartilage condensation kidney development negative regulation of endothelial cell proliferation chondrocyte development glomerular filtration catalytic activity arylsulfatase activity calcium ion binding glycosaminoglycan binding extracellular space endoplasmic reticulum Golgi apparatus Golgi stack plasma membrane sulfur compound metabolic process apoptotic process cell adhesion N-acetylglucosamine-6-sulfatase activity sulfuric ester hydrolase activity cell surface positive regulation of vascular endothelial growth factor production esophagus smooth muscle contraction negative regulation of angiogenesis hydrolase activity positive regulation of Wnt signaling pathway heparan sulfate proteoglycan metabolic process negative regulation of cell migration positive regulation of BMP signaling pathway glomerular basement membrane development glial cell-derived neurotrophic factor receptor signaling pathway limb joint morphogenesis regulation of fibroblast growth factor receptor signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway membrane raft metal ion binding vascular endothelial growth factor receptor signaling pathway positive regulation of smooth muscle cell proliferation embryonic skeletal system development cartilage development bone development innervation negative regulation of prostatic bud formation uc007aia.1 uc007aia.2 uc007aia.3 uc007aia.4 
ENSMUST00000177622.4 Trav7-3 ENSMUST00000177622.4 Trav7-3 (from geneSymbol) ENSMUST00000177622.1 ENSMUST00000177622.2 ENSMUST00000177622.3 Q5R1I1 Q5R1I1_MOUSE TRAV7D-3 Trav7-3 Trav7d-3 X01133 uc007tsd.1 uc007tsd.2 uc007tsd.3 uc007tsd.1 uc007tsd.2 uc007tsd.3 
ENSMUST00000177631.3 Gm25626 ENSMUST00000177631.3 Gm25626 (from geneSymbol) ENSMUST00000177631.1 ENSMUST00000177631.2 uc287qsb.1 uc287qsb.2 uc287qsb.1 uc287qsb.2 
ENSMUST00000177632.2 Vmn1r155 ENSMUST00000177632.2 vomeronasal 1 receptor 155 (from RefSeq NM_001166753.1) D3YTY1 D3YTY1_MOUSE ENSMUST00000177632.1 NM_001166753 Vmn1r107 Vmn1r130 Vmn1r137 Vmn1r155 Vmn1r165 uc012feg.1 uc012feg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012feg.1 uc012feg.2 
ENSMUST00000177638.2 E030018B13Rik ENSMUST00000177638.2 RIKEN cDNA E030018B13 gene (from RefSeq NM_001256311.1) E030018B13Rik ENSMUST00000177638.1 J3QMS9 J3QMS9_MOUSE NM_001256311 uc029wgd.1 uc029wgd.2 molecular_function cellular_component biological_process uc029wgd.1 uc029wgd.2 
ENSMUST00000177639.7 Gm20831 ENSMUST00000177639.7 Belongs to the SPIN/STSY family. (from UniProt Q3TTD8) AK132684 ENSMUST00000177639.1 ENSMUST00000177639.2 ENSMUST00000177639.3 ENSMUST00000177639.4 ENSMUST00000177639.5 ENSMUST00000177639.6 Gm20737 Gm20772 Gm20777 Gm20793 Gm20831 Gm21425 Gm21440 Q3TTD8 Q3TTD8_MOUSE uc057mct.1 uc057mct.2 uc057mct.3 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc057mct.1 uc057mct.2 uc057mct.3 
ENSMUST00000177642.8 Celf1 ENSMUST00000177642.8 CUGBP, Elav-like family member 1, transcript variant 7 (from RefSeq NM_001406166.1) A2AFW9 A2AFX0 A2AFX1 A2AFX2 Brunol2 CELF1_MOUSE Cugbp Cugbp1 ENSMUST00000177642.1 ENSMUST00000177642.2 ENSMUST00000177642.3 ENSMUST00000177642.4 ENSMUST00000177642.5 ENSMUST00000177642.6 ENSMUST00000177642.7 NM_001406166 P28659 Q3U0N2 Q3UP93 Q3UY22 Q8R532 Q99PE1 Q9CXE5 Q9EPJ8 Q9JI37 uc008kty.1 uc008kty.2 uc008kty.3 uc008kty.4 RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (By similarity). Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition (By similarity). Acts both as an activator and a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (By similarity). Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB (By similarity). Promotes exclusion of exon 11 of the INSR pre-mRNA (By similarity). Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast (By similarity). Increases translation and controls the choice of translation initiation codon of CEBPB mRNA (By similarity). Increases mRNA translation of CEBPB in aging liver. Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3 (By similarity). Mediates rapid cytoplasmic mRNA deadenylation (By similarity). Recruits the deadenylase PARN to the poly(A) tail of EDEN- containing mRNAs to promote their deadenylation (By similarity). Required for completion of spermatogenesis. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs) (By similarity). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). Binds to AU-rich sequences (AREs or EDEN- like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA (By similarity). Binds to the 5'-region of CDKN1A and CEBPB mRNAs (By similarity). Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (By similarity). Associates with polysomes (By similarity). Interacts with HNRNPH1; the interaction in RNA-dependent. Interacts with PARN (By similarity). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Nucleus. Cytoplasm. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments. Event=Alternative splicing; Named isoforms=4; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=LYLQ; IsoId=P28659-1; Sequence=Displayed; Name=2; IsoId=P28659-2; Sequence=VSP_005786; Name=3; Synonyms=A; IsoId=P28659-3; Sequence=VSP_005786, VSP_005787; Name=4; IsoId=P28659-4; Sequence=VSP_026789; Expressed in skeletal muscle, uterus, diaphragm, lung, spleen, testis, mammary gland, adipose, eye and brain (at protein level). Strongly expressed in aging liver (at protein level). Expressed in lung, stomach, heart to very low levels (at protein level). Expressed in germ cells of the seminiferous tubules except in the central region that contains the elongated spermatids and spermatozoa (at protein level). Expressed in Leydig cells of the interstitial tissue (at protein level). Expressed in the heart, skeletal muscle, testis (from spermatogonia to round spermatids), spleen, lung, neocortex, cerebellar cortex, hippocampus and other areas, abundant in the putamen, and poorly expressed in the thalamus and in the brain stem. Expressed in heart, muscle, brain, liver, thigh, stomach and lung at 14 dpc (at protein level). Expressed from the two- cell to blastocyst stages. Expressed in tail region, somites, cephalic structures and limb buds at 10.5 dpc. Its RNA-binding activity on CEBPB mRNA increases in response to EGF. RRM1 and RRM2 domains preferentially target UGU(U/G)-rich mRNA elements. Phosphorylated. Phosphorylated by CDK4 on Ser-302. Its phosphorylation status increases in aging liver and is important for the formation of the EIF2 complex and activation of CEBPB mRNA translation. Hyperphosphorylated in the EIF2 complex. EGFR signaling regulates its phosphorylation status in epithelial cells. Belongs to the CELF/BRUNOL family. Sequence=CAA43691.1; Type=Frameshift; Evidence=; regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding nucleus nucleoplasm cytoplasm mRNA splice site selection mRNA processing spermatid development RNA splicing translation initiation factor binding positive regulation of multicellular organism growth BRE binding regulation of RNA splicing ribonucleoprotein complex uc008kty.1 uc008kty.2 uc008kty.3 uc008kty.4 
ENSMUST00000177646.2 Ighd5-4 ENSMUST00000177646.2 Ighd5-4 (from geneSymbol) ENSMUST00000177646.1 uc288jsm.1 uc288jsm.2 uc288jsm.1 uc288jsm.2 
ENSMUST00000177647.8 Pdzk1ip1 ENSMUST00000177647.8 PDZK1 interacting protein 1, transcript variant 3 (from RefSeq NM_001164558.1) ENSMUST00000177647.1 ENSMUST00000177647.2 ENSMUST00000177647.3 ENSMUST00000177647.4 ENSMUST00000177647.5 ENSMUST00000177647.6 ENSMUST00000177647.7 Map17 NM_001164558 PDZ1I_MOUSE Q9CQH0 uc012djc.1 uc012djc.2 Interacts with PDZK1. Forms a heterodimer with SLC5A2; this interaction enhances SLC5A2 transporter activity over a hundred-fold. Membrane ; Single-pass membrane protein molecular_function biological_process membrane integral component of membrane uc012djc.1 uc012djc.2 
ENSMUST00000177659.3 Anxa2r2 ENSMUST00000177659.3 Anxa2r2 (from geneSymbol) Anxa2r1 Anxa2r2 ENSMUST00000177659.1 ENSMUST00000177659.2 Q3T9V6 Q3T9V6_MOUSE uc288qgc.1 uc288qgc.2 uc288qgc.3 signaling receptor activity uc288qgc.1 uc288qgc.2 uc288qgc.3 
ENSMUST00000177666.3 Gm20738 ENSMUST00000177666.3 predicted gene, 20738 (from RefSeq NM_207162.2) ENSMUST00000177666.1 ENSMUST00000177666.2 Gm20738 Gm20823 Gm20924 Gm21249 LOC382133 NM_207162 Q810R8 Q810R8_MOUSE uc029xxt.1 uc029xxt.2 uc029xxt.3 uc029xxt.4 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc029xxt.1 uc029xxt.2 uc029xxt.3 uc029xxt.4 
ENSMUST00000177678.2 Fam240a ENSMUST00000177678.2 family with sequence similarity 240 member A (from RefSeq NM_001195437.2) ENSMUST00000177678.1 Fam240a Gm590 J3QNP9 J3QNP9_MOUSE NM_001195437 uc012hbm.1 uc012hbm.2 molecular_function cellular_component biological_process uc012hbm.1 uc012hbm.2 
ENSMUST00000177683.2 Astx4a ENSMUST00000177683.2 Astx4a (from geneSymbol) DQ874390 ENSMUST00000177683.1 uc292qjd.1 uc292qjd.2 uc292qjd.1 uc292qjd.2 
ENSMUST00000177684.3 Ms4a18 ENSMUST00000177684.3 membrane-spanning 4-domains, subfamily A, member 18 (from RefSeq NM_001251849.1) ENSMUST00000177684.1 ENSMUST00000177684.2 J3QN01 J3QN01_MOUSE Ms4a18 NM_001251849 uc008grm.1 uc008grm.2 uc008grm.3 Belongs to the MS4A family. molecular_function cellular_component biological_process membrane integral component of membrane uc008grm.1 uc008grm.2 uc008grm.3 
ENSMUST00000177688.3 n-R5s210 ENSMUST00000177688.3 n-R5s210 (from geneSymbol) AB352541 ENSMUST00000177688.1 ENSMUST00000177688.2 uc287hjs.1 uc287hjs.2 uc287hjs.1 uc287hjs.2 
ENSMUST00000177703.3 Trav12d-3 ENSMUST00000177703.3 Trav12d-3 (from geneSymbol) A0A075B6A4 A0A075B6A4_MOUSE A0N8Q8 ENSMUST00000177703.1 ENSMUST00000177703.2 Trav12d-3 Trav12n-3 uc288txn.1 uc288txn.2 immunoglobulin production extracellular space immune response uc288txn.1 uc288txn.2 
ENSMUST00000177705.3 Trav9n-3 ENSMUST00000177705.3 Trav9n-3 (from geneSymbol) A0A075B695 A0A075B695_MOUSE AK040993 ENSMUST00000177705.1 ENSMUST00000177705.2 Trav9d-3 Trav9n-3 uc288tzd.1 uc288tzd.2 uc288tzd.1 uc288tzd.2 
ENSMUST00000177706.3 Gm26178 ENSMUST00000177706.3 Gm26178 (from geneSymbol) DQ558729 ENSMUST00000177706.1 ENSMUST00000177706.2 uc288ycv.1 uc288ycv.2 uc288ycv.1 uc288ycv.2 
ENSMUST00000177714.8 2010315B03Rik ENSMUST00000177714.8 RIKEN cDNA 2010315B03 gene, transcript variant 3 (from RefSeq NM_001243119.1) 2010315B03Rik ENSMUST00000177714.1 ENSMUST00000177714.2 ENSMUST00000177714.3 ENSMUST00000177714.4 ENSMUST00000177714.5 ENSMUST00000177714.6 ENSMUST00000177714.7 J3QK55 J3QK55_MOUSE NM_001243119 uc057mba.1 uc057mba.2 uc057mba.3 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc057mba.1 uc057mba.2 uc057mba.3 
ENSMUST00000177719.2 ENSMUSG00000096756 ENSMUST00000177719.2 ENSMUSG00000096756 (from geneSymbol) AK145597 ENSMUST00000177719.1 uc291cfg.1 uc291cfg.2 uc291cfg.1 uc291cfg.2 
ENSMUST00000177724.2 Astx1c ENSMUST00000177724.2 Astx1c (from geneSymbol) DQ874390 ENSMUST00000177724.1 uc292qjq.1 uc292qjq.2 uc292qjq.1 uc292qjq.2 
ENSMUST00000177744.3 Cdc5lrt9 ENSMUST00000177744.3 Belongs to the CEF1 family. (from UniProt A0A1W2P7H4) A0A1W2P7H4 A0A1W2P7H4_MOUSE Cdc5lrt9 ENSMUST00000177744.1 ENSMUST00000177744.2 Gm9048 LF224722 uc029riy.1 uc029riy.2 uc029riy.3 Belongs to the CEF1 family. DNA binding uc029riy.1 uc029riy.2 uc029riy.3 
ENSMUST00000177752.9 Fkbp2 ENSMUST00000177752.9 FK506 binding protein 2, transcript variant 3 (from RefSeq NM_001360286.1) ENSMUST00000177752.1 ENSMUST00000177752.2 ENSMUST00000177752.3 ENSMUST00000177752.4 ENSMUST00000177752.5 ENSMUST00000177752.6 ENSMUST00000177752.7 ENSMUST00000177752.8 Fkbp2 NM_001360286 Q3TND1 Q3TND1_MOUSE uc008gju.1 uc008gju.2 uc008gju.3 uc008gju.4 uc008gju.5 Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence= protein peptidyl-prolyl isomerization peptidyl-prolyl cis-trans isomerase activity isomerase activity uc008gju.1 uc008gju.2 uc008gju.3 uc008gju.4 uc008gju.5 
ENSMUST00000177762.3 Cdc5lrt5 ENSMUST00000177762.3 Belongs to the CEF1 family. (from UniProt A0A1W2P6Q8) A0A1W2P6Q8 A0A1W2P6Q8_MOUSE Cdc5lrt5 Cdc5lrt6 ENSMUST00000177762.1 ENSMUST00000177762.2 Gm9040 Gm9044 LF224720 uc029rhw.1 uc029rhw.2 uc029rhw.3 Belongs to the CEF1 family. DNA binding uc029rhw.1 uc029rhw.2 uc029rhw.3 
ENSMUST00000177768.3 Fam177a ENSMUST00000177768.3 family with sequence similarity 177, member A (from RefSeq NM_028527.2) ENSMUST00000177768.1 ENSMUST00000177768.2 F177A_MOUSE Fam177a1 NM_028527 Q8BR63 Q9D9M7 uc007nog.1 uc007nog.2 uc007nog.3 uc007nog.4 Belongs to the FAM177 family. Sequence=BAB24712.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc007nog.1 uc007nog.2 uc007nog.3 uc007nog.4 
ENSMUST00000177771.3 Gm13278 ENSMUST00000177771.3 predicted gene 13278 (from RefSeq NM_001098841.3) B1AYI0 ENSMUST00000177771.1 ENSMUST00000177771.2 Gm13277 Gm13278 Gm13279 Gm13288 Gm13289 Gm13290 NM_001098841 Q8CD73 Q8CD73_MOUSE uc008tns.1 uc008tns.2 uc008tns.3 uc008tns.4 uc008tns.5 uc008tns.6 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tns.1 uc008tns.2 uc008tns.3 uc008tns.4 uc008tns.5 uc008tns.6 
ENSMUST00000177774.3 Vmn1r148 ENSMUST00000177774.3 vomeronasal 1 receptor 148 (from RefSeq NM_030736.2) ENSMUST00000177774.1 ENSMUST00000177774.2 NM_030736 Q9EPS5 Q9EPS5_MOUSE Vmn1r100 Vmn1r148 uc009foa.1 uc009foa.2 uc009foa.3 uc009foa.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc009foa.1 uc009foa.2 uc009foa.3 uc009foa.4 
ENSMUST00000177783.2 Vmn1r186 ENSMUST00000177783.2 vomeronasal 1 receptor Vmn1r186 (from RefSeq NM_001167567.1) ENSMUST00000177783.1 NM_001167567 uc009veq.1 uc009veq.2 uc009veq.3 uc009veq.4 uc009veq.1 uc009veq.2 uc009veq.3 uc009veq.4 
ENSMUST00000177785.3 Ccl27b ENSMUST00000177785.3 C-C motif chemokine ligand 27b, transcript variant 2 (from RefSeq NM_001199959.2) CCL27_MOUSE Ccl27 ENSMUST00000177785.1 ENSMUST00000177785.2 Ilc NM_001199959 Q3KNL1 Q9DAU6 Q9DAZ4 Q9Z1X0 Scya27 uc008snp.1 uc008snp.2 uc008snp.3 uc008snp.4 Chemotactic factor that attracts skin-associated memory T- lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10. Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization. Interacts with TNFAIP6 (via Link domain). [Isoform 1]: Secreted Nucleus Note=May also be nuclear when following receptor (CCR10)-mediated internalization. [Isoform 2]: Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z1X0-1; Sequence=Displayed; Name=2; Synonyms=PESKY; IsoId=Q9Z1X0-2; Sequence=VSP_001065; Isoform 1 is predominantly expressed in placenta and weakly in skin. Isoform 2 is predominantly expressed in testes and brain, weakly in kidney and liver and even lower in heart and muscle. Low expression of both isoforms in other tissues. Expressed during development. Belongs to the intercrine beta (chemokine CC) family. It is uncertain whether Met-1 or Met-2 is the initiator. Name=Wikipedia; Note=CCL27 entry; URL="https://en.wikipedia.org/wiki/CCL27"; cytokine activity protein binding extracellular region extracellular space nucleus immune response signal transduction chemokine activity positive regulation of T cell chemotaxis cell chemotaxis positive regulation of mononuclear cell migration positive regulation of actin cytoskeleton reorganization uc008snp.1 uc008snp.2 uc008snp.3 uc008snp.4 
ENSMUST00000177794.2 Mir5123 ENSMUST00000177794.2 microRNA 5123 (from RefSeq NR_039584.1) ENSMUST00000177794.1 NR_039584 uc029uqe.1 uc029uqe.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029uqe.1 uc029uqe.2 
ENSMUST00000177800.8 Rita1 ENSMUST00000177800.8 RBPJ interacting and tubulin associated 1, transcript variant 1 (from RefSeq NM_133908.1) ENSMUST00000177800.1 ENSMUST00000177800.2 ENSMUST00000177800.3 ENSMUST00000177800.4 ENSMUST00000177800.5 ENSMUST00000177800.6 ENSMUST00000177800.7 NM_133908 Q9D1H0 RITA1_MOUSE Rita uc012ecr.1 uc012ecr.2 uc012ecr.3 Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity). Interacts with RBPJ/RBPSUH. Cytoplasm Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear (By similarity). Belongs to the RITA family. nucleus cytoplasm centrosome microtubule organizing center cytoskeleton Notch signaling pathway nervous system development tubulin binding neurogenesis negative regulation of Notch signaling pathway nuclear export uc012ecr.1 uc012ecr.2 uc012ecr.3 
ENSMUST00000177806.2 Gm13290 ENSMUST00000177806.2 predicted gene 13290 (from RefSeq NM_001243155.1) B1AYI0 ENSMUST00000177806.1 Gm13277 Gm13278 Gm13279 Gm13288 Gm13289 Gm13290 NM_001243155 Q8CD73 Q8CD73_MOUSE uc029uwu.1 uc029uwu.2 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc029uwu.1 uc029uwu.2 
ENSMUST00000177815.2 Vmn1r100 ENSMUST00000177815.2 vomeronasal 1 receptor 100 (from RefSeq NM_001166844.1) ENSMUST00000177815.1 NM_001166844 Q9EPS5 Q9EPS5_MOUSE Vmn1r100 Vmn1r148 uc012fbx.1 uc012fbx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fbx.1 uc012fbx.2 
ENSMUST00000177839.2 Ighd2-3 ENSMUST00000177839.2 Ighd2-3 (from geneSymbol) ENSMUST00000177839.1 uc288jsw.1 uc288jsw.2 uc288jsw.1 uc288jsw.2 
ENSMUST00000177843.2 ENSMUSG00000094172 ENSMUST00000177843.2 ENSMUSG00000094172 (from geneSymbol) ENSMUST00000177843.1 uc291cfp.1 uc291cfp.2 uc291cfp.1 uc291cfp.2 
ENSMUST00000177853.2 ENSMUSG00000096236 ENSMUST00000177853.2 ENSMUSG00000096236 (from geneSymbol) BC147369 ENSMUST00000177853.1 uc291cff.1 uc291cff.2 uc291cff.1 uc291cff.2 
ENSMUST00000177856.8 Txnrd2 ENSMUST00000177856.8 Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:20347; Evidence=; (from UniProt J3QMQ8) BC052157 ENSMUST00000177856.1 ENSMUST00000177856.2 ENSMUST00000177856.3 ENSMUST00000177856.4 ENSMUST00000177856.5 ENSMUST00000177856.6 ENSMUST00000177856.7 J3QMQ8 J3QMQ8_MOUSE Txnrd2 uc289ddy.1 uc289ddy.2 Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:20347; Evidence=; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Homodimer. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. nucleotide binding thioredoxin-disulfide reductase activity cell electron carrier activity oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor electron transport chain cell redox homeostasis flavin adenine dinucleotide binding oxidation-reduction process cellular oxidant detoxification uc289ddy.1 uc289ddy.2 
ENSMUST00000177872.3 Gm24388 ENSMUST00000177872.3 Gm24388 (from geneSymbol) ENSMUST00000177872.1 ENSMUST00000177872.2 uc288sml.1 uc288sml.2 uc288sml.1 uc288sml.2 
ENSMUST00000177884.2 Vmn1r137 ENSMUST00000177884.2 vomeronasal 1 receptor 137 (from RefSeq NM_001166849.1) D3YTY1 D3YTY1_MOUSE ENSMUST00000177884.1 NM_001166849 Vmn1r107 Vmn1r130 Vmn1r137 Vmn1r155 Vmn1r165 uc012fdn.1 uc012fdn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fdn.1 uc012fdn.2 
ENSMUST00000177893.3 G530011O06Riky ENSMUST00000177893.3 G530011O06Riky (from geneSymbol) ENSMUST00000177893.1 ENSMUST00000177893.2 uc292vak.1 uc292vak.2 uc292vak.3 uc292vak.1 uc292vak.2 uc292vak.3 
ENSMUST00000177908.2 Cfap73 ENSMUST00000177908.2 cilia and flagella associated protein 73 (from RefSeq NM_001195094.1) CFA73_MOUSE Ccdc42b Cfap73 ENSMUST00000177908.1 J3QPZ5 NM_001195094 uc012ecs.1 uc012ecs.2 May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm. Cytoplasm, cytoskeleton, cilium axoneme Belongs to the CFAP73 family. cilium movement molecular_function cellular_component cytoplasm cytoskeleton cilium biological_process motile cilium inner dynein arm assembly cell projection dynein complex binding axonemal outer doublet regulation of microtubule motor activity uc012ecs.1 uc012ecs.2 
ENSMUST00000177912.2 Btbd35f13 ENSMUST00000177912.2 BTB domain containing 35, family member 13 (from RefSeq NM_001282034.1) B8JKF6 B8JKF6_MOUSE Btbd35f13 ENSMUST00000177912.1 Gm2927 NM_001282034 uc033jpd.1 uc033jpd.2 uc033jpd.3 molecular_function cellular_component biological_process uc033jpd.1 uc033jpd.2 uc033jpd.3 
ENSMUST00000177921.2 ENSMUSG00000096808 ENSMUST00000177921.2 ENSMUSG00000096808 (from geneSymbol) DQ720098 ENSMUST00000177921.1 uc289spn.1 uc289spn.2 uc289spn.1 uc289spn.2 
ENSMUST00000177923.3 Gm26285 ENSMUST00000177923.3 Gm26285 (from geneSymbol) ENSMUST00000177923.1 ENSMUST00000177923.2 uc291bfz.1 uc291bfz.2 uc291bfz.1 uc291bfz.2 
ENSMUST00000177926.3 H2al1h ENSMUST00000177926.3 H2A histone family member L1H (from RefSeq NM_001242953.1) ENSMUST00000177926.1 ENSMUST00000177926.2 H2AL1_MOUSE H2al1a H2al1c H2al1d H2al1f H2al1g H2al1h H2al1i NM_001242953 Q5M8Q2 uc029xih.1 uc029xih.2 uc029xih.3 uc029xih.4 Atypical histone H2A which can replace conventional H2A in some nucleosomes and may play a role during spermatogenesis. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes, replacing one or more H2A molecules. Interacts with H2BC1/TH2B; preferentially dimerizes with H2BC1/TH2B to form nucleosomes (PubMed:17261847). Nucleus Chromosome Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847). Testis-specific. Strongly enriched in step 12-16 spermatids and accumulate during late spermiogenesis, in condensing spermatids (PubMed:17261847). Remains present in mature spermatozoa isolated from epididymis (PubMed:17261847). Rapidly disappears from the paternal pericentric heterochromatin regions after sperm-egg fusion (PubMed:18703863). In contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding protein binding nucleus chromosome pericentric heterochromatin DNA packaging chromatin organization spermatogenesis cell differentiation DNA packaging complex protein heterodimerization activity uc029xih.1 uc029xih.2 uc029xih.3 uc029xih.4 
ENSMUST00000177934.3 Gm1553 ENSMUST00000177934.3 predicted gene 1553 (from RefSeq NM_001255990.1) ENSMUST00000177934.1 ENSMUST00000177934.2 Gm1553 Lcrn NM_001255990 Q66VB7 Q66VB7_MOUSE uc007gjo.1 uc007gjo.2 uc007gjo.3 uc007gjo.4 molecular_function cellular_component biological_process uc007gjo.1 uc007gjo.2 uc007gjo.3 uc007gjo.4 
ENSMUST00000177935.3 Gm22584 ENSMUST00000177935.3 Gm22584 (from geneSymbol) ENSMUST00000177935.1 ENSMUST00000177935.2 uc291qtl.1 uc291qtl.2 uc291qtl.1 uc291qtl.2 
ENSMUST00000177936.2 Vmn1r130 ENSMUST00000177936.2 vomeronasal 1 receptor 130 (from RefSeq NM_001166848.1) D3YTY1 D3YTY1_MOUSE ENSMUST00000177936.1 NM_001166848 Vmn1r107 Vmn1r130 Vmn1r137 Vmn1r155 Vmn1r165 uc012fcj.1 uc012fcj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fcj.1 uc012fcj.2 
ENSMUST00000177943.8 Slc45a3 ENSMUST00000177943.8 solute carrier family 45, member 3, transcript variant 2 (from RefSeq NM_001177628.2) ENSMUST00000177943.1 ENSMUST00000177943.2 ENSMUST00000177943.3 ENSMUST00000177943.4 ENSMUST00000177943.5 ENSMUST00000177943.6 ENSMUST00000177943.7 NM_001177628 Pcanap6 Prst Q8K0H7 Q8K252 Q8R1I0 S45A3_MOUSE uc007cnz.1 uc007cnz.2 uc007cnz.3 uc007cnz.4 Proton-associated sucrose transporter. May be able to transport also glucose and fructose. Reaction=H(+)(out) + sucrose(out) = H(+)(in) + sucrose(in); Xref=Rhea:RHEA:72187, ChEBI:CHEBI:15378, ChEBI:CHEBI:17992; Evidence=; Kinetic parameters: KM=4.4 mM for sucrose ; pH dependence: Optimum pH is 6.5. ; Membrane ; Multi-pass membrane protein Expressed in the epididymis (PubMed:14561649). Primarily expressed in the prostate, but also in other tissues (PubMed:25164149). Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. integral component of plasma membrane sucrose:proton symporter activity positive regulation of glucose metabolic process sucrose transport membrane integral component of membrane positive regulation of fatty acid biosynthetic process regulation of oligodendrocyte differentiation transmembrane transport uc007cnz.1 uc007cnz.2 uc007cnz.3 uc007cnz.4 
ENSMUST00000177945.2 Alyreffm8 ENSMUST00000177945.2 predicted gene 4307 (from RefSeq NM_001166641.1) B2RY44 E9PZY4 E9PZY4_MOUSE EG667568 ENSMUST00000177945.1 Gm4303 Gm4305 Gm4307 NM_001166641 uc057kjn.1 uc057kjn.2 molecular_function nucleic acid binding RNA binding cellular_component biological_process uc057kjn.1 uc057kjn.2 
ENSMUST00000177948.2 Aspn ENSMUST00000177948.2 asporin, transcript variant 1 (from RefSeq NM_025711.3) ASPN_MOUSE ENSMUST00000177948.1 NM_025711 Q99MQ4 Q9D6A2 uc007qjn.1 uc007qjn.2 uc007qjn.3 uc007qjn.4 uc007qjn.5 This gene encodes a member of the small leucine-rich proteoglycan family. The encoded protein is an extracellular matrix protein that modulates the transforming growth factor-beta signaling pathway, regulating cartilage matrix gene expression and cartilage formation. The protein plays a role in the pathology of osteoarthritis. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity (By similarity). Critical regulator of TGF- beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF- beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins. Inhibits the interaction between TGFB1 and TGF-beta receptor type II in the presence of heparin/heparan sulfate in vitro. Interacts with type I collagen. DCN can inhibit collagen binding (By similarity). Interacts with TGFB1, TGFB2 and TGFB3. DCN, BGN, and FMOD inhibit binding to TGFB1. Interacts with BMP2. Interacts in vitro with type II collagen. Secreted, extracellular space, extracellular matrix Higher expression in heart, also detected in kidney, stomach, testes, and skin but only weakly in lung, skeletal muscle, small intestine, and thymus. Expressed specifically and predominantly in the periodontal ligament (PDL). During tooth development, strong expression is seen in the dental follicle, which is the progenitor tissue that forms cementum, alveolar bone, and the PDL. Expressed in the perichondria of the maxilla, mandible, vertebrae, and long bones. Predominantly expressed in the perichondrium/periosteum of long bones (at protein level). At 12.5 dpc, it is present in the mandibular as well as maxillary components of the first branchial arch. Also detected in the thoracic body wall adjacent to the heart. At 13.5 dpc, it is detected in the mesenchyme lateral to Meckel's cartilage. Pronounced expression is observed in the perichondrium of the humerus, ribs, and scapula. At 14.5 dpc, it is detected in the mesenchymal condensations lateral to Meckel's cartilage, in the perichondrium surrounding the central cartilaginous elements of the vertebra and also in the dermal mesenchyme. At 15.5 dpc, it is expressed in the perichondrium/periosteum of the long bones (i.e. femur, tibia, and fibula), some of the flat bones at the base of the skull (i.e. sphenoid bone), ribs, clavicle, and vertebrae. Also detected in the intramembranous bones of the maxilla and mandible (alveolar bone) and a strong expression is observed in sagittal sections of the subcutaneous muscles or panniculus carnosus of the thorax, trunk, and head/ neck (platysma muscle) region. Very little expression is detected in the major parenchymal organs (with the exception of the large bronchi of the lung). Its expression is prominent in the developing mouse skeleton, particularly in the perichondrium/periosteum of cartilage/bone, and is also found in other specialized connective tissues such as tendon, sclera, the connective tissue sheath surrounding muscle and dermis. In the sclera of the eye it is first detected at 15.5 dpc and stronger expression was detected at 17.5 dpc. By TGFB1. Induction requires ALK5 kinase activity and SMAD3. The repeats LRR 9, LRR 10 and LRR 11 are involved in binding type I collagen. The poly-Asp region is involved in binding calcium (By similarity). The LRR 5 repeat can inhibit BMP2-induced cytodifferentiation and may be involved in the interaction with BMP2. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. Sequence=AK014504; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; calcium ion binding protein binding collagen binding extracellular region extracellular matrix structural constituent conferring compression resistance bone mineralization negative regulation of transforming growth factor beta receptor signaling pathway extracellular matrix biomineral tissue development cell projection negative regulation of tooth mineralization uc007qjn.1 uc007qjn.2 uc007qjn.3 uc007qjn.4 uc007qjn.5 
ENSMUST00000177952.8 Gprc5c ENSMUST00000177952.8 G protein-coupled receptor, family C, group 5, member C, transcript variant 3 (from RefSeq NM_001110338.1) ENSMUST00000177952.1 ENSMUST00000177952.2 ENSMUST00000177952.3 ENSMUST00000177952.4 ENSMUST00000177952.5 ENSMUST00000177952.6 ENSMUST00000177952.7 Gprc5c J3JS84 J3JS84_MOUSE NM_001110338 RP23-254J18.2-003 uc011yhg.1 uc011yhg.2 uc011yhg.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity G-protein coupled receptor signaling pathway membrane integral component of membrane uc011yhg.1 uc011yhg.2 uc011yhg.3 
ENSMUST00000177955.8 Naxd ENSMUST00000177955.8 NAD(P)HX dehydratase, transcript variant 2 (from RefSeq NM_001190357.1) CARKD Carkd ENSMUST00000177955.1 ENSMUST00000177955.2 ENSMUST00000177955.3 ENSMUST00000177955.4 ENSMUST00000177955.5 ENSMUST00000177955.6 ENSMUST00000177955.7 J3QMM7 J3QMM7_MOUSE NM_001190357 Naxd uc009kvf.1 uc009kvf.2 uc009kvf.3 uc009kvf.4 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Reaction=(6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate; Xref=Rhea:RHEA:19017, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57945, ChEBI:CHEBI:64074, ChEBI:CHEBI:456216; EC=4.2.1.93; Evidence= Reaction=(6S)-NADPHX + ATP = ADP + H(+) + NADPH + phosphate; Xref=Rhea:RHEA:32231, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:64076, ChEBI:CHEBI:456216; EC=4.2.1.93; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Mitochondrion Belongs to the NnrD/CARKD family. nucleotide binding ATP binding mitochondrion lyase activity nicotinamide nucleotide metabolic process ATP-dependent NAD(P)H-hydrate dehydratase activity ADP-dependent NAD(P)H-hydrate dehydratase activity uc009kvf.1 uc009kvf.2 uc009kvf.3 uc009kvf.4 
ENSMUST00000177958.2 Gal3st2b ENSMUST00000177958.2 Belongs to the galactose-3-O-sulfotransferase family. (from UniProt J3QMJ1) AY216522 ENSMUST00000177958.1 Gal3st2b J3QMJ1 J3QMJ1_MOUSE uc287krc.1 uc287krc.2 Belongs to the galactose-3-O-sulfotransferase family. galactosylceramide sulfotransferase activity cellular_component Golgi apparatus sulfotransferase activity biological_process glycolipid biosynthetic process membrane integral component of membrane uc287krc.1 uc287krc.2 
ENSMUST00000177961.3 Gm24798 ENSMUST00000177961.3 Gm24798 (from geneSymbol) ENSMUST00000177961.1 ENSMUST00000177961.2 uc288qgb.1 uc288qgb.2 uc288qgb.1 uc288qgb.2 
ENSMUST00000177962.9 Bcap29 ENSMUST00000177962.9 B cell receptor associated protein 29, transcript variant 2 (from RefSeq NM_001164090.1) BAP29_MOUSE Bap29 ENSMUST00000177962.1 ENSMUST00000177962.2 ENSMUST00000177962.3 ENSMUST00000177962.4 ENSMUST00000177962.5 ENSMUST00000177962.6 ENSMUST00000177962.7 ENSMUST00000177962.8 NM_001164090 Q61334 uc007nhq.1 uc007nhq.2 uc007nhq.3 uc007nhq.4 May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8- mediated apoptosis (By similarity). Homodimer and heterodimer with BCAP31. Binds CASP8 as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II (By similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein. Highly expressed in brain and testis; detected at lower levels in thymus, spleen, liver, lung and bone marrow. Belongs to the BCAP29/BCAP31 family. endoplasmic reticulum endoplasmic reticulum membrane integral component of plasma membrane intracellular protein transport ER to Golgi vesicle-mediated transport apoptotic process protein transport membrane integral component of membrane vesicle-mediated transport protein localization to endoplasmic reticulum exit site uc007nhq.1 uc007nhq.2 uc007nhq.3 uc007nhq.4 
ENSMUST00000177963.8 Senp8 ENSMUST00000177963.8 Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. (from UniProt Q9D2Z4) AK029856 Den1 ENSMUST00000177963.1 ENSMUST00000177963.2 ENSMUST00000177963.3 ENSMUST00000177963.4 ENSMUST00000177963.5 ENSMUST00000177963.6 ENSMUST00000177963.7 Nedp1 Q543P0 Q9D2Z4 SENP8_MOUSE uc009pyp.1 uc009pyp.2 uc009pyp.3 uc009pyp.4 Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. Belongs to the peptidase C48 family. Sequence=BAB31304.1; Type=Erroneous initiation; Evidence=; proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity NEDD8-specific protease activity uc009pyp.1 uc009pyp.2 uc009pyp.3 uc009pyp.4 
ENSMUST00000177965.2 Ighd2-7 ENSMUST00000177965.2 Ighd2-7 (from geneSymbol) ENSMUST00000177965.1 uc288jsk.1 uc288jsk.2 uc288jsk.1 uc288jsk.2 
ENSMUST00000177978.3 Fam177a2 ENSMUST00000177978.3 family with sequence similarity 177 member A2 (from RefSeq NM_001100116.1) ENSMUST00000177978.1 ENSMUST00000177978.2 F177A_MOUSE Fam177a1 NM_001100116 Q8BR63 Q9D9M7 uc007noj.1 uc007noj.2 uc007noj.3 Belongs to the FAM177 family. Sequence=BAB24712.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc007noj.1 uc007noj.2 uc007noj.3 
ENSMUST00000177979.2 ENSMUSG00000096244 ENSMUST00000177979.2 vomeronasal 1 receptor Vmn1r187 (from RefSeq NM_001167568.1) ENSMUST00000177979.1 NM_001167568 uc012fyf.1 uc012fyf.2 uc012fyf.1 uc012fyf.2 
ENSMUST00000177986.8 Gm3500 ENSMUST00000177986.8 predicted gene 3500 (from RefSeq NM_001256886.1) A6NAS7 A6NAS7_MOUSE ENSMUST00000177986.1 ENSMUST00000177986.2 ENSMUST00000177986.3 ENSMUST00000177986.4 ENSMUST00000177986.5 ENSMUST00000177986.6 ENSMUST00000177986.7 Gm3373 Gm3500 NM_001256886 uc007sck.1 uc007sck.2 uc007sck.3 uc007sck.4 uc007sck.1 uc007sck.2 uc007sck.3 uc007sck.4 
ENSMUST00000177988.4 Mir466b-2 ENSMUST00000177988.4 microRNA 466b-2 (from RefSeq NR_030564.1) ENSMUST00000177988.1 ENSMUST00000177988.2 ENSMUST00000177988.3 NR_030564 uc056zjr.1 uc056zjr.2 uc056zjr.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zjr.1 uc056zjr.2 uc056zjr.3 
ENSMUST00000177991.2 ENSMUSG00000096680 ENSMUST00000177991.2 ENSMUSG00000096680 (from geneSymbol) ENSMUST00000177991.1 uc291cfc.1 uc291cfc.2 uc291cfc.1 uc291cfc.2 
ENSMUST00000177994.8 ENSMUSG00000121587 ENSMUST00000177994.8 spermatogenesis associated multipass transmembrane protein 1b (from RefSeq NM_001201358.1) 4921511M17Rik A2BED8 A2BED8_MOUSE ENSMUST00000177994.1 ENSMUST00000177994.2 ENSMUST00000177994.3 ENSMUST00000177994.4 ENSMUST00000177994.5 ENSMUST00000177994.6 ENSMUST00000177994.7 Gm10057 Gm5645 NM_001201358 Samt1 Samt1b Samt1c uc009ure.1 uc009ure.2 uc009ure.3 uc009ure.4 molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc009ure.1 uc009ure.2 uc009ure.3 uc009ure.4 
ENSMUST00000177997.3 Gm24754 ENSMUST00000177997.3 Gm24754 (from geneSymbol) ENSMUST00000177997.1 ENSMUST00000177997.2 uc289exe.1 uc289exe.2 uc289exe.1 uc289exe.2 
ENSMUST00000178003.8 Slc25a19 ENSMUST00000178003.8 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19, transcript variant 2 (from RefSeq NM_001252384.1) A2A9V6 ENSMUST00000178003.1 ENSMUST00000178003.2 ENSMUST00000178003.3 ENSMUST00000178003.4 ENSMUST00000178003.5 ENSMUST00000178003.6 ENSMUST00000178003.7 NM_001252384 Q3T9C4 Q9DAM5 TPC_MOUSE uc029rpw.1 uc029rpw.2 uc029rpw.3 Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient. Reaction=thiamine diphosphate(in) + thiamine phosphate(out) = thiamine diphosphate(out) + thiamine phosphate(in); Xref=Rhea:RHEA:73383, ChEBI:CHEBI:37575, ChEBI:CHEBI:58937; Evidence=; Mitochondrion membrane ; Multi-pass membrane protein Deficient mice are embryonically lethal, with death occurring on or before day 11 of the embryo development. Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations and anemia. Belongs to the mitochondrial carrier (TC 2.A.29) family. Previously identified as the mitochondrial deoxyribonucleotide carrier. However other experiments later demonstrated that SLC25A19 is a thiamine diphosphate transporter and not a mitochondrial deoxyribonucleotide carrier. mitochondrion mitochondrial inner membrane thiamine transmembrane transporter activity membrane integral component of membrane transmembrane transporter activity thiamine pyrophosphate transport integral component of mitochondrial inner membrane transmembrane transport thiamine transmembrane transport uc029rpw.1 uc029rpw.2 uc029rpw.3 
ENSMUST00000178026.2 Raet1e ENSMUST00000178026.2 Acts as a ligand for KLRK1. (from UniProt Q9CZQ6) A2RSZ5 D64162 ENSMUST00000178026.1 Q9CZQ6 RAE1E_MOUSE uc057kib.1 uc057kib.2 uc057kib.3 Acts as a ligand for KLRK1. Cell membrane ; Lipid-anchor, GPI- anchor By retinoic acid. Glycosylated. Belongs to the NKG2D ligand family. T cell mediated cytotoxicity extracellular space plasma membrane immune response external side of plasma membrane membrane anchored component of membrane spanning component of plasma membrane positive regulation of natural killer cell mediated cytotoxicity anchored component of plasma membrane natural killer cell lectin-like receptor binding uc057kib.1 uc057kib.2 uc057kib.3 
ENSMUST00000178033.5 Kiss1 ENSMUST00000178033.5 Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Intracerebroventricular administration induces an increase in serum LH and FSH levels in prepubertal male and female as well as in adult animals. (from UniProt Q6Y4S4) AB666166 ENSMUST00000178033.1 ENSMUST00000178033.2 ENSMUST00000178033.3 ENSMUST00000178033.4 KISS1_MOUSE Q149Z8 Q68Y93 Q6Y4S4 Q80XF6 uc287ltx.1 uc287ltx.2 Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Intracerebroventricular administration induces an increase in serum LH and FSH levels in prepubertal male and female as well as in adult animals. Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6Y4S4-1; Sequence=Displayed; Name=2; IsoId=Q6Y4S4-2; Sequence=VSP_012957; Weak in all tissue types with highest levels in lung and 15- 17-day embryos. Expressed in areas of the hypothalamus implicated in the neuroendocrine regulation of gonadotropin secretion, including the anteroventral periventricular nucleus, the periventricular nucleus, and the arcuate nucleus. Animals are viable and healthy with no apparent abnormalities but fail to undergo sexual maturation. Mutant female do not progress through the estrous cycle, have thread-like uteri and small ovaries, and do not produce mature Graffian follicles. Mutant males have small testes, and spermatogenesis arrested mainly at the early haploid spermatid stage. Both sexes have low circulating gonadotropin (LH and FSH) and sex steroid (beta-estradiol or testosterone) hormone levels. Migration of GnRH neurons into the hypothalamus appears normal with appropriate axonal connections to the median eminence and total GnRH content. The hypothalamic-pituitary axis is functional, as shown by robust LH secretion after peripheral administration of kisspeptin. Belongs to the KISS1 family. Sequence=AAO64981.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; extracellular region extracellular space cytoplasm G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration negative regulation of cell proliferation apical plasma membrane kisspeptin receptor binding positive regulation of luteinizing hormone secretion neuron projection neuronal cell body positive regulation of MAPK cascade decidualization positive regulation of synaptic transmission positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway generation of ovulation cycle rhythm positive regulation of growth hormone secretion uc287ltx.1 uc287ltx.2 
ENSMUST00000178036.8 Axdnd1 ENSMUST00000178036.8 Axdnd1 (from geneSymbol) AK134071 Axdnd1 ENSMUST00000178036.1 ENSMUST00000178036.2 ENSMUST00000178036.3 ENSMUST00000178036.4 ENSMUST00000178036.5 ENSMUST00000178036.6 ENSMUST00000178036.7 J3QPL7 J3QPL7_MOUSE uc287muv.1 uc287muv.2 uc287muv.1 uc287muv.2 
ENSMUST00000178037.2 Esp16 ENSMUST00000178037.2 exocrine gland secreted peptide 16 (from RefSeq NM_001255977.1) 100043300 A8R0U9 A8R0U9_MOUSE ENSMUST00000178037.1 Esp16 Gm4345 NM_001255977 uc029thu.1 uc029thu.2 pheromone activity extracellular space biological_process uc029thu.1 uc029thu.2 
ENSMUST00000178039.2 Gm21903 ENSMUST00000178039.2 Gm21903 (from geneSymbol) ENSMUST00000178039.1 Gm21903 J3QMQ1 J3QMQ1_MOUSE uc289lda.1 uc289lda.2 pheromone activity extracellular space uc289lda.1 uc289lda.2 
ENSMUST00000178045.9 Mfsd4b4 ENSMUST00000178045.9 major facilitator superfamily domain containing 4B4, transcript variant 3 (from RefSeq NM_001416571.1) AA474331 ENSMUST00000178045.1 ENSMUST00000178045.2 ENSMUST00000178045.3 ENSMUST00000178045.4 ENSMUST00000178045.5 ENSMUST00000178045.6 ENSMUST00000178045.7 ENSMUST00000178045.8 J3QNS5 J3QNS5_MOUSE Mfsd4b4 NM_001416571 uc287qqb.1 uc287qqb.2 uc287qqb.3 Membrane ; Multi- pass membrane protein glucose transmembrane transporter activity integral component of plasma membrane membrane integral component of membrane transmembrane transport glucose transmembrane transport uc287qqb.1 uc287qqb.2 uc287qqb.3 
ENSMUST00000178051.8 Faiml ENSMUST00000178051.8 Fas apoptotic inhibitory molecule like (from RefSeq NM_001244762.1) ENSMUST00000178051.1 ENSMUST00000178051.2 ENSMUST00000178051.3 ENSMUST00000178051.4 ENSMUST00000178051.5 ENSMUST00000178051.6 ENSMUST00000178051.7 Faiml Gm6432 J3QPY3 J3QPY3_MOUSE NM_001244762 uc029xfr.1 uc029xfr.2 molecular_function cellular_component I-kappaB kinase/NF-kappaB signaling negative regulation of apoptotic process positive regulation of neurogenesis negative regulation of extrinsic apoptotic signaling pathway via death domain receptors uc029xfr.1 uc029xfr.2 
ENSMUST00000178059.3 Rnu6-ps2 ENSMUST00000178059.3 Rnu6-ps2 (from geneSymbol) ENSMUST00000178059.1 ENSMUST00000178059.2 uc290plo.1 uc290plo.2 uc290plo.1 uc290plo.2 
ENSMUST00000178065.3 Gm4791 ENSMUST00000178065.3 predicted gene 4791 (from RefSeq NR_177948.1) ENSMUST00000178065.1 ENSMUST00000178065.2 NR_177948 uc029wyq.1 uc029wyq.2 uc029wyq.1 uc029wyq.2 
ENSMUST00000178080.3 Btbd35f24 ENSMUST00000178080.3 Btbd35f24 (from geneSymbol) Btbd35f24 ENSMUST00000178080.1 ENSMUST00000178080.2 Gm21364 J3QNQ5 J3QNQ5_MOUSE uc292mue.1 uc292mue.2 uc292mue.1 uc292mue.2 
ENSMUST00000178085.8 Magec2 ENSMUST00000178085.8 MAGE family member C2, transcript variant 2 (from RefSeq NM_001199997.1) 4933402E13Rik ENSMUST00000178085.1 ENSMUST00000178085.2 ENSMUST00000178085.3 ENSMUST00000178085.4 ENSMUST00000178085.5 ENSMUST00000178085.6 ENSMUST00000178085.7 Magec2 NM_001199997 Q9D4D2 Q9D4D2_MOUSE uc012hif.1 uc012hif.2 molecular_function cellular_component biological_process uc012hif.1 uc012hif.2 
ENSMUST00000178089.3 Gm25244 ENSMUST00000178089.3 Gm25244 (from geneSymbol) ENSMUST00000178089.1 ENSMUST00000178089.2 uc290nsw.1 uc290nsw.2 uc290nsw.1 uc290nsw.2 
ENSMUST00000178099.4 Gm23050 ENSMUST00000178099.4 Gm23050 (from geneSymbol) ENSMUST00000178099.1 ENSMUST00000178099.2 ENSMUST00000178099.3 uc289gva.1 uc289gva.2 uc289gva.1 uc289gva.2 
ENSMUST00000178100.3 Trav7n-6 ENSMUST00000178100.3 Trav7n-6 (from geneSymbol) A0A0B4J1N1 A0A0B4J1N1_MOUSE AK050592 C920008G01Rik ENSMUST00000178100.1 ENSMUST00000178100.2 Trav7d-6 Trav7n-6 uc288tzp.1 uc288tzp.2 molecular_function cellular_component biological_process uc288tzp.1 uc288tzp.2 
ENSMUST00000178114.2 Lipa ENSMUST00000178114.2 lysosomal acid lipase A, transcript variant 2 (from RefSeq NM_001111100.1) ENSMUST00000178114.1 LICH_MOUSE Lip1 NM_001111100 Q8C2G7 Q9Z0M5 uc008hgm.1 uc008hgm.2 uc008hgm.3 uc008hgm.4 Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. Reaction=a sterol ester + H2O = a fatty acid + a sterol + H(+); Xref=Rhea:RHEA:10100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15889, ChEBI:CHEBI:28868, ChEBI:CHEBI:35915; EC=3.1.1.13; Evidence=; Reaction=cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+); Xref=Rhea:RHEA:33875, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30823, ChEBI:CHEBI:46898; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33876; Evidence=; Monomer. Lysosome Expressed at low levels in most tissues. High level expression is found in hepatocytes and splenic and thymic cells. Very high level expression is observed in cells of the small intestinal villi, the zona fasciculata and reticularis of the adrenal cortex, pancreatic acini, and renal tubular epithelium. Glycosylation is not essential for catalytic activity. Belongs to the AB hydrolase superfamily. Lipase family. cell morphogenesis fibrillar center cytokine production sterol esterase activity lysosome lipid metabolic process fatty acid metabolic process inflammatory response cell proliferation lipid catabolic process sterol metabolic process lipase activity hydrolase activity hydrolase activity, acting on ester bonds lung development intracellular membrane-bounded organelle tissue remodeling homeostasis of number of cells within a tissue uc008hgm.1 uc008hgm.2 uc008hgm.3 uc008hgm.4 
ENSMUST00000178120.9 Gm11007 ENSMUST00000178120.9 Gm11007 (from geneSymbol) A2ART4 A2ART4_MOUSE AK010871 ENSMUST00000178120.1 ENSMUST00000178120.2 ENSMUST00000178120.3 ENSMUST00000178120.4 ENSMUST00000178120.5 ENSMUST00000178120.6 ENSMUST00000178120.7 ENSMUST00000178120.8 Gm11007 Gm14308 Gm14434 Gm2007 Gm2026 Gm4631 Gm4724 RP23-376N23.4-001 RP24-574J13.1-003 uc290dcu.1 uc290dcu.2 uc290dcu.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290dcu.1 uc290dcu.2 uc290dcu.3 
ENSMUST00000178124.3 Tpbgl ENSMUST00000178124.3 trophoblast glycoprotein-like (from RefSeq NM_001195529.1) ENSMUST00000178124.1 ENSMUST00000178124.2 Gm4980 NM_001195529 Q8C013 TPBGL_MOUSE uc012fpx.1 uc012fpx.2 uc012fpx.3 Membrane ; Single-pass type I membrane protein membrane integral component of membrane uc012fpx.1 uc012fpx.2 uc012fpx.3 
ENSMUST00000178129.2 Gm28373 ENSMUST00000178129.2 Gm28373 (from geneSymbol) AK018648 ENSMUST00000178129.1 uc288iuc.1 uc288iuc.2 uc288iuc.1 uc288iuc.2 
ENSMUST00000178133.9 Gm2007 ENSMUST00000178133.9 predicted gene 2007 (from RefSeq NM_001378595.1) A2ART4 A2ART4_MOUSE ENSMUST00000178133.1 ENSMUST00000178133.2 ENSMUST00000178133.3 ENSMUST00000178133.4 ENSMUST00000178133.5 ENSMUST00000178133.6 ENSMUST00000178133.7 ENSMUST00000178133.8 Gm11007 Gm14308 Gm14434 Gm2007 Gm2026 Gm4631 Gm4724 NM_001378595 RP23-376N23.4-001 RP24-574J13.1-003 uc290ddb.1 uc290ddb.2 uc290ddb.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290ddb.1 uc290ddb.2 uc290ddb.3 
ENSMUST00000178134.2 Mdn1 ENSMUST00000178134.2 midasin AAA ATPase 1 (from RefSeq NM_001081392.1) ENSMUST00000178134.1 J3QMC5 J3QMC5_MOUSE Mdn1 NM_001081392 uc008sfa.1 uc008sfa.2 Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Nucleus, nucleolus Nucleus, nucleoplasm Belongs to the midasin family. ribosomal large subunit assembly nucleotide binding molecular_function ATP binding nucleus nucleolus cytosol rRNA processing ATPase activity intermediate filament cytoskeleton uc008sfa.1 uc008sfa.2 
ENSMUST00000178136.8 Abcc3 ENSMUST00000178136.8 ATP-binding cassette, sub-family C member 3, transcript variant 3 (from RefSeq NM_001363189.1) B2RX12 Cmoat2 ENSMUST00000178136.1 ENSMUST00000178136.2 ENSMUST00000178136.3 ENSMUST00000178136.4 ENSMUST00000178136.5 ENSMUST00000178136.6 ENSMUST00000178136.7 J3QML2 MRP3_MOUSE Mrp3 NM_001363189 Q3U1W8 Q56PH0 Q59DK9 Q59DL0 Q5SUF4 Q80ZK8 uc007kyn.1 uc007kyn.2 ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (By similarity). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (PubMed:15814571, PubMed:16225954). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity). Reaction=an S-substituted glutathione(in) + ATP + H2O = ADP + an S- substituted glutathione(out) + H(+) + phosphate; Xref=Rhea:RHEA:19121, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:90779, ChEBI:CHEBI:456216; EC=7.6.2.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19122; Evidence=; Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.; EC=7.6.2.2; Evidence=; Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:82961, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60129; Evidence=; Reaction=ATP + dehydroepiandrosterone 3-sulfate(in) + H2O = ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate; Xref=Rhea:RHEA:61364, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57905, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61365; Evidence=; Reaction=ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate; Xref=Rhea:RHEA:38963, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57973, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38964; Evidence=; Reaction=ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out); Xref=Rhea:RHEA:50052, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36257, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50053; Evidence=; Reaction=ATP + glycocholate(in) + H2O = ADP + glycocholate(out) + H(+) + phosphate; Xref=Rhea:RHEA:50056, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29746, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50057; Evidence=; Reaction=ATP + H2O + taurolithocholate 3-sulfate(in) = ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out); Xref=Rhea:RHEA:50084, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58301, ChEBI:CHEBI:456216; Evidence=; Reaction=ATP + H2O + taurochenodeoxycholate 3-sulfate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out); Xref=Rhea:RHEA:66176, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:166912, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66177; Evidence=; Reaction=ATP + bilirubin-glucuronoside(in) + H2O = ADP + bilirubin- glucuronoside(out) + H(+) + phosphate; Xref=Rhea:RHEA:66180, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57767, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66181; Evidence=; Reaction=ATP + bilirubin-bisglucuronoside(in) + H2O = ADP + bilirubin- bisglucuronoside(out) + H(+) + phosphate; Xref=Rhea:RHEA:66192, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58471, ChEBI:CHEBI:456216; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66193; Evidence=; Basolateral cell membrane ; Multi-pass membrane protein Basal cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=B2RX12-1; Sequence=Displayed; Name=2; IsoId=B2RX12-2; Sequence=VSP_036012; Name=3; IsoId=B2RX12-3; Sequence=VSP_036011; Detected throughout the gastrointestinal tract, liver, lung, pancreas, bladder, gall bladder and at low levels in the adrenal gland. Deficient mice do not exhibit any overt phenotype under normal conditions. However when challenged with cholestasis induced by bile duct ligation, increased levels of hepatic bile salts and lower serum levels of bilirubin glucuronide are observed, suggesting that Abcc3 provides an alternative route for removal from the liver of these substrates under cholestatic conditions. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. nucleotide binding ATP binding integral component of plasma membrane drug transmembrane transport canalicular bile acid transport drug transport membrane integral component of membrane basolateral plasma membrane ATPase activity transmembrane transporter activity ATPase activity, coupled to transmembrane movement of substances transmembrane transport uc007kyn.1 uc007kyn.2 
ENSMUST00000178142.2 Nim1k ENSMUST00000178142.2 NIM1 serine/threonine protein kinase (from RefSeq NM_175538.3) ENSMUST00000178142.1 NIM1_MOUSE NM_175538 Nim1 Q148V1 Q80XC1 Q8BHI9 Q8BXQ9 uc007rzu.1 uc007rzu.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation at Thr-229, probably by autophosphorylation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity intracellular signal transduction metal ion binding uc007rzu.1 uc007rzu.2 
ENSMUST00000178143.2 Btbd35f27 ENSMUST00000178143.2 BTB domain containing 35, family member 27 (from RefSeq NM_001243024.1) Btbd35f27 ENSMUST00000178143.1 Gm3763 Gmcl1l NM_001243024 Q5FWA1 Q5FWA1_MOUSE uc029xhs.1 uc029xhs.2 molecular_function cellular_component biological_process uc029xhs.1 uc029xhs.2 
ENSMUST00000178145.8 Gm16430 ENSMUST00000178145.8 predicted gene 16430 (from RefSeq NM_001166601.1) A6X8J1 A6X8J1_MOUSE ENSMUST00000178145.1 ENSMUST00000178145.2 ENSMUST00000178145.3 ENSMUST00000178145.4 ENSMUST00000178145.5 ENSMUST00000178145.6 ENSMUST00000178145.7 Gm14594 Gm16405 Gm16430 Gm7958 NM_001166601 uc009tfq.1 uc009tfq.2 uc009tfq.3 synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc009tfq.1 uc009tfq.2 uc009tfq.3 
ENSMUST00000178147.3 ENSMUSG00000121769 ENSMUST00000178147.3 ENSMUSG00000121769 (from geneSymbol) BC002014 ENSMUST00000178147.1 ENSMUST00000178147.2 uc292rhl.1 uc292rhl.2 uc292rhl.1 uc292rhl.2 
ENSMUST00000178149.3 Gm20825 ENSMUST00000178149.3 Belongs to the SPIN/STSY family. (from UniProt J3QM67) ENSMUST00000178149.1 ENSMUST00000178149.2 Gm20825 J3QM67 J3QM67_MOUSE uc292scl.1 uc292scl.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292scl.1 uc292scl.2 
ENSMUST00000178159.2 Zfp616 ENSMUST00000178159.2 zinc finger protein 616 (from RefSeq NM_001177570.1) ENSMUST00000178159.1 J3QN14 J3QN14_MOUSE NM_001177570 Zfp616 uc033fyb.1 uc033fyb.2 Nucleus transcription regulatory region sequence-specific DNA binding nucleic acid binding cellular_component biological_process uc033fyb.1 uc033fyb.2 
ENSMUST00000178160.4 Gm379 ENSMUST00000178160.4 Gm379 (from geneSymbol) ENSMUST00000178160.1 ENSMUST00000178160.2 ENSMUST00000178160.3 uc292qcl.1 uc292qcl.2 uc292qcl.3 uc292qcl.4 uc292qcl.1 uc292qcl.2 uc292qcl.3 uc292qcl.4 
ENSMUST00000178162.3 Zfp790 ENSMUST00000178162.3 zinc finger protein 790, transcript variant 2 (from RefSeq NM_001145880.1) ENSMUST00000178162.1 ENSMUST00000178162.2 NM_001145880 Q80ZX2 Q80ZX2_MOUSE Zfp790 uc009gce.1 uc009gce.2 uc009gce.3 uc009gce.4 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc009gce.1 uc009gce.2 uc009gce.3 uc009gce.4 
ENSMUST00000178167.4 Alyreffm2 ENSMUST00000178167.4 Alyreffm2 (from geneSymbol) A0A991ENX0 A0A991ENX0_MOUSE ENSMUST00000178167.1 ENSMUST00000178167.2 ENSMUST00000178167.3 Gm6489 uc287has.1 uc287has.2 uc287has.3 uc287has.1 uc287has.2 uc287has.3 
ENSMUST00000178168.3 Ccl21e ENSMUST00000178168.3 C-C motif chemokine ligand 21E (from RefSeq NM_001193668.1) CC21C_MOUSE Ccl21c ENSMUST00000178168.1 ENSMUST00000178168.2 NM_001193668 O09002 O09006 P84443 P86793 Q5M8M5 Q91V84 Scya21c uc008snn.1 uc008snn.2 uc008snn.3 uc008snn.4 Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to CCR7 and to CXCR3. Interacts with PDPN; relocalizes PDPN to the basolateral membrane. Interacts with GPR174. Secreted. Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart. Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while Ccl21a has 'Ser-65' (6Ckine-Ser). Belongs to the intercrine beta (chemokine CC) family. monocyte chemotaxis cytokine activity extracellular region extracellular space chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway chemokine activity neutrophil chemotaxis CCR7 chemokine receptor binding chemokine receptor binding positive regulation of GTPase activity CCR chemokine receptor binding lymphocyte chemotaxis cell chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor uc008snn.1 uc008snn.2 uc008snn.3 uc008snn.4 
ENSMUST00000178169.2 Gm15085 ENSMUST00000178169.2 predicted gene 15085 (from RefSeq NM_001122734.1) ENSMUST00000178169.1 Gm15085 NM_001122734 Ott Q62012 Q62012_MOUSE uc009uob.1 uc009uob.2 molecular_function cellular_component biological_process uc009uob.1 uc009uob.2 
ENSMUST00000178174.3 Pou3f2 ENSMUST00000178174.3 POU domain, class 3, transcription factor 2 (from RefSeq NM_008899.2) A2AJY1 Brn-2 Brn2 ENSMUST00000178174.1 ENSMUST00000178174.2 NM_008899 Otf7 P31360 PO3F2_MOUSE uc008sdp.1 uc008sdp.2 uc008sdp.3 uc008sdp.4 Transcription factor that plays a key role in neuronal differentiation (PubMed:24243019). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (PubMed:18505825, PubMed:18403418). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (PubMed:24243019). Interacts with PQBP1 (By similarity). Interaction with ISL1 (PubMed:24643061). Nucleus. Expressed specifically in the neuroectodermal cell lineage. Belongs to the POU transcription factor family. Class-3 subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nervous system development brain development positive regulation of cell proliferation epidermis development negative regulation of gene expression astrocyte development Schwann cell development cerebral cortex radially oriented cell migration forebrain ventricular zone progenitor cell division hypothalamus cell differentiation neurohypophysis development myelination in peripheral nervous system cell differentiation neuron differentiation positive regulation of multicellular organism growth identical protein binding sequence-specific DNA binding regulation of cell differentiation positive regulation of transcription from RNA polymerase II promoter neuron fate commitment neuron fate specification neuron development regulation of axonogenesis cellular response to organic substance HMG box domain binding uc008sdp.1 uc008sdp.2 uc008sdp.3 uc008sdp.4 
ENSMUST00000178178.2 1700001F09Rik ENSMUST00000178178.2 RIKEN cDNA 1700001F09 gene (from RefSeq NM_027940.2) 1700001F09Rik ENSMUST00000178178.1 NM_027940 Q9DAR5 Q9DAR5_MOUSE uc007tcz.1 uc007tcz.2 uc007tcz.3 molecular_function biological_process uc007tcz.1 uc007tcz.2 uc007tcz.3 
ENSMUST00000178179.2 1600014C23Rik ENSMUST00000178179.2 RIKEN cDNA 1600014C23 gene (from RefSeq NM_028164.1) 1600014C23Rik ENSMUST00000178179.1 NM_028164 Q9DAX4 Q9DAX4_MOUSE uc008crk.1 uc008crk.2 molecular_function cellular_component biological_process uc008crk.1 uc008crk.2 
ENSMUST00000178181.3 Gm21943 ENSMUST00000178181.3 predicted gene, 21943 (from RefSeq NM_001017393.3) ENSMUST00000178181.1 ENSMUST00000178181.2 Gm20818 Gm21163 Gm21184 Gm21247 Gm21281 Gm21573 Gm21943 MGC107098 NM_001017393 Q5FWD5 Q5FWD5_MOUSE uc029ybo.1 uc029ybo.2 uc029ybo.3 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc029ybo.1 uc029ybo.2 uc029ybo.3 
ENSMUST00000178192.3 Spata31f1c ENSMUST00000178192.3 spermatogenesis associated 31 subfamily F member 1D (from RefSeq NM_001357590.1) 31F14_MOUSE A2APU8 C0HKD3 ENSMUST00000178192.1 ENSMUST00000178192.2 Fam205a4 NM_001357590 Spata31f1-4 uc057lhp.1 uc057lhp.2 uc057lhp.3 uc057lhp.4 Membrane ; Single-pass membrane protein Belongs to the SPATA31 family. membrane integral component of membrane uc057lhp.1 uc057lhp.2 uc057lhp.3 uc057lhp.4 
ENSMUST00000178196.3 H2al1k ENSMUST00000178196.3 H2A histone family member L1K (from RefSeq NM_001085537.2) ENSMUST00000178196.1 ENSMUST00000178196.2 Gm14501 H2al1k J3QP08 J3QP08_MOUSE NM_001085537 uc009spt.1 uc009spt.2 uc009spt.3 uc009spt.4 The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc009spt.1 uc009spt.2 uc009spt.3 uc009spt.4 
ENSMUST00000178199.2 ENSMUSG00000094874 ENSMUST00000178199.2 sp110 nuclear body protein-like (from RefSeq NM_001378696.1) ENSMUST00000178199.1 NM_001378696 uc289spj.1 uc289spj.2 uc289spj.1 uc289spj.2 
ENSMUST00000178206.2 Dlx6os2 ENSMUST00000178206.2 distal-less homeobox 6, opposite strand 2 (from RefSeq NR_002839.2) ENSMUST00000178206.1 NR_002839 uc009awx.1 uc009awx.2 uc009awx.3 uc009awx.1 uc009awx.2 uc009awx.3 
ENSMUST00000178207.10 1600014C10Rik ENSMUST00000178207.10 RIKEN cDNA 1600014C10 gene, transcript variant 1 (from RefSeq NM_001085385.1) CS012_MOUSE ENSMUST00000178207.1 ENSMUST00000178207.2 ENSMUST00000178207.3 ENSMUST00000178207.4 ENSMUST00000178207.5 ENSMUST00000178207.6 ENSMUST00000178207.7 ENSMUST00000178207.8 ENSMUST00000178207.9 NM_001085385 Q58E27 Q8K308 Q8WUR0 Q9DAX5 uc291oqm.1 uc291oqm.2 Mitochondrion Mitochondrion membrane ; Single-pass membrane protein Endoplasmic reticulum Cytoplasm, cytosol Note=In response to oxidative stress, relocates to the cytosol forming aggregates that partially co-localize with mitochondria. Belongs to the C19orf12 family. Sequence=AAH92099.1; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm mitochondrion endoplasmic reticulum cytosol autophagy apoptotic process response to oxidative stress membrane integral component of membrane mitochondrial membrane mitochondrial calcium ion homeostasis uc291oqm.1 uc291oqm.2 
ENSMUST00000178215.2 Vmn1r157 ENSMUST00000178215.2 vomeronasal 1 receptor 157 (from RefSeq NM_001166754.1) E9Q069 E9Q069_MOUSE ENSMUST00000178215.1 NM_001166754 Vmn1r157 uc012fei.1 uc012fei.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fei.1 uc012fei.2 
ENSMUST00000178224.2 D430019H16Rik ENSMUST00000178224.2 RIKEN cDNA D430019H16 gene (from RefSeq NM_001252508.1) D430019H16Rik ENSMUST00000178224.1 J3QPM6 J3QPM6_MOUSE NM_001252508 uc007oyk.1 uc007oyk.2 uc007oyk.3 molecular_function cellular_component biological_process membrane integral component of membrane uc007oyk.1 uc007oyk.2 uc007oyk.3 
ENSMUST00000178227.6 Gm21847 ENSMUST00000178227.6 spermatogenesis associated glutamate (E)-rich protein 8, pseudogene 1 (from RefSeq NR_001584.3) ENSMUST00000178227.1 ENSMUST00000178227.2 ENSMUST00000178227.3 ENSMUST00000178227.4 ENSMUST00000178227.5 NR_001584 uc290tgp.1 uc290tgp.2 uc290tgp.1 uc290tgp.2 
ENSMUST00000178229.3 Ighv2-3 ENSMUST00000178229.3 Ighv2-3 (from geneSymbol) A0A075B696 A0A075B696_MOUSE ENSMUST00000178229.1 ENSMUST00000178229.2 FM177890 Ighv2-3 uc288jtj.1 uc288jtj.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jtj.1 uc288jtj.2 
ENSMUST00000178230.2 Ighd2-6 ENSMUST00000178230.2 Ighd2-6 (from geneSymbol) ENSMUST00000178230.1 uc288jsn.1 uc288jsn.2 uc288jsn.1 uc288jsn.2 
ENSMUST00000178231.2 Gm49322 ENSMUST00000178231.2 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; (from UniProt Q6PAT0) ADAT3_MOUSE Adat3 BC060071 ENSMUST00000178231.1 Q6PAT0 uc033frd.1 uc033frd.2 uc033frd.3 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily. Val-225 is present instead of the conserved Glu which is an active site in the cytidine and deoxycytidylate deaminase family of enzymes. It is suggested that this protein may act as a regulatory subunit. tRNA wobble adenosine to inosine editing catalytic activity tRNA processing metal ion binding tRNA-specific adenosine-34 deaminase activity tRNA-specific adenosine-34 deaminase complex uc033frd.1 uc033frd.2 uc033frd.3 
ENSMUST00000178232.4 Ppp1r2-ps1 ENSMUST00000178232.4 Ppp1r2-ps1 (from geneSymbol) ENSMUST00000178232.1 ENSMUST00000178232.2 ENSMUST00000178232.3 uc289gtf.1 uc289gtf.2 uc289gtf.3 uc289gtf.1 uc289gtf.2 uc289gtf.3 
ENSMUST00000178236.3 Pate3 ENSMUST00000178236.3 prostate and testis expressed 3 (from RefSeq NM_001167592.3) B3GLJ3 D8KWR6 ENSMUST00000178236.1 ENSMUST00000178236.2 Gm17365 NM_001167592 PATE3_MOUSE uc012gql.1 uc012gql.2 Secreted Belongs to the PATE family. extracellular region uc012gql.1 uc012gql.2 
ENSMUST00000178238.8 Tmem52 ENSMUST00000178238.8 transmembrane protein 52, transcript variant 1 (from RefSeq NM_027161.2) B7ZN39 B7ZN39_MOUSE ENSMUST00000178238.1 ENSMUST00000178238.2 ENSMUST00000178238.3 ENSMUST00000178238.4 ENSMUST00000178238.5 ENSMUST00000178238.6 ENSMUST00000178238.7 NM_027161 Tmem52 uc012dqr.1 uc012dqr.2 uc012dqr.3 membrane integral component of membrane uc012dqr.1 uc012dqr.2 uc012dqr.3 
ENSMUST00000178250.3 Gm24136 ENSMUST00000178250.3 Gm24136 (from geneSymbol) DQ548138 ENSMUST00000178250.1 ENSMUST00000178250.2 uc057lge.1 uc057lge.2 uc057lge.1 uc057lge.2 
ENSMUST00000178252.3 Trav9d-3 ENSMUST00000178252.3 Trav9d-3 (from geneSymbol) A0A075B695 A0A075B695_MOUSE AK040993 ENSMUST00000178252.1 ENSMUST00000178252.2 Trav9d-3 Trav9n-3 uc288txl.1 uc288txl.2 uc288txl.1 uc288txl.2 
ENSMUST00000178258.3 Scgb2b7 ENSMUST00000178258.3 secretoglobin, family 2B, member 7 (from RefSeq NM_001198871.1) Abpbg7 D3YYY1 D3YYY1_MOUSE ENSMUST00000178258.1 ENSMUST00000178258.2 NM_001198871 Scgb2b7 uc029weq.1 uc029weq.2 uc029weq.3 Secreted Belongs to the secretoglobin family. molecular_function cellular_component extracellular space biological_process uc029weq.1 uc029weq.2 uc029weq.3 
ENSMUST00000178282.3 Igha ENSMUST00000178282.3 Igha (from geneSymbol) A0A075B6A3 A0A075B6A3_MOUSE AK142609 ENSMUST00000178282.1 ENSMUST00000178282.2 Igha uc288jre.1 uc288jre.2 mucosal immune response humoral immune response mediated by circulating immunoglobulin antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin mediated immune response immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jre.1 uc288jre.2 
ENSMUST00000178285.3 Mir935 ENSMUST00000178285.3 microRNA 935 (from RefSeq NR_128566.1) ENSMUST00000178285.1 ENSMUST00000178285.2 NR_128566 uc057afj.1 uc057afj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057afj.1 uc057afj.2 
ENSMUST00000178291.2 ENSMUSG00000094741 ENSMUST00000178291.2 Belongs to the PRAME family. (from UniProt Q8C9W1) A430089I19Rik BC147369 ENSMUST00000178291.1 Pramel39 Pramel39-ps Q8C9W1 Q8C9W1_MOUSE uc291cev.1 uc291cev.2 Belongs to the PRAME family. cytoplasm positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc291cev.1 uc291cev.2 
ENSMUST00000178296.2 ENSMUSG00000096728 ENSMUST00000178296.2 ENSMUSG00000096728 (from geneSymbol) BC061212 ENSMUST00000178296.1 uc291cfa.1 uc291cfa.2 uc291cfa.1 uc291cfa.2 
ENSMUST00000178301.3 Eif1ad16 ENSMUST00000178301.3 eukaryotic translation initiation factor 1A domain containing 16 (from RefSeq NM_001354576.1) ENSMUST00000178301.1 ENSMUST00000178301.2 Eif1ad16 J3QPI8 J3QPI8_MOUSE NM_001354576 uc288ifj.1 uc288ifj.2 uc288ifj.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. molecular_function RNA binding translation initiation factor activity cellular_component translation translational initiation biological_process uc288ifj.1 uc288ifj.2 uc288ifj.3 
ENSMUST00000178309.2 ENSMUSG00000095500 ENSMUST00000178309.2 ENSMUSG00000095500 (from geneSymbol) ENSMUST00000178309.1 uc289spk.1 uc289spk.2 uc289spk.1 uc289spk.2 
ENSMUST00000178310.9 Fau ENSMUST00000178310.9 [Ubiquitin-like protein FUBI]: May have pro-apoptotic activity. (from UniProt P62862) AK132752 ENSMUST00000178310.1 ENSMUST00000178310.2 ENSMUST00000178310.3 ENSMUST00000178310.4 ENSMUST00000178310.5 ENSMUST00000178310.6 ENSMUST00000178310.7 ENSMUST00000178310.8 P35545 P62862 Q05472 Q642K5 Q95261 Q9JJ24 RS30_MOUSE uc008ggt.1 uc008ggt.2 uc008ggt.3 uc008ggt.4 [Ubiquitin-like protein FUBI]: May have pro-apoptotic activity. [Small ribosomal subunit protein eS30]: Component of the 40S subunit of the ribosome (PubMed:36517592). Contributes to the assembly and function of 40S ribosomal subunits (By similarity). [Small ribosomal subunit protein eS30]: Component of the 40S subunit of the ribosome. P62862; Q9CPT0: Bcl2l14; NbExp=4; IntAct=EBI-309546, EBI-8296066; P62862; Q62419: Sh3gl1; NbExp=3; IntAct=EBI-309546, EBI-642935; [Small ribosomal subunit protein eS30]: Nucleus Cytoplasm FUBI is cleaved from ribosomal protein S30 by the deubiquitinase USP36 before the assembly of ribosomal protein S30 into pre-40S ribosomal particles. FUBI removal from ribosomal protein S30 is a crucial event for the final maturation of pre-40S particles. FAU encodes a fusion protein consisting of the ubiquitin-like protein FUBI at the N terminus and ribosomal protein S30 at the C terminus. [Ubiquitin-like protein FUBI]: Lacks the typical lysine residues that participate in Ub's polyubiquitination. However contains a C-terminal di-glycine signature after its proteolytic separation from ribosomal protein S30 and could theoretically be conjugated onto target proteins. In the N-terminal section; belongs to the ubiquitin family. In the C-terminal section; belongs to the eukaryotic ribosomal protein eS30 family. innate immune response in mucosa structural constituent of ribosome extracellular space ribosome translation antibacterial humoral response cytosolic small ribosomal subunit defense response to Gram-positive bacterium uc008ggt.1 uc008ggt.2 uc008ggt.3 uc008ggt.4 
ENSMUST00000178317.4 Alyreffm3 ENSMUST00000178317.4 Alyreffm3 (from geneSymbol) A0A3B2W7J0 A0A3B2W7J0_MOUSE ENSMUST00000178317.1 ENSMUST00000178317.2 ENSMUST00000178317.3 Gm5698 uc287had.1 uc287had.2 molecular_function nucleic acid binding RNA binding cellular_component biological_process uc287had.1 uc287had.2 
ENSMUST00000178318.2 ENSMUSG00000095763 ENSMUST00000178318.2 ENSMUSG00000095763 (from geneSymbol) BC099967 ENSMUST00000178318.1 uc291cfr.1 uc291cfr.2 uc291cfr.1 uc291cfr.2 
ENSMUST00000178319.2 Msantd5f5 ENSMUST00000178319.2 Myb/SANT DNA binding domain containing 5 family member 5 (from RefSeq NM_001277575.2) ENSMUST00000178319.1 F2Z3W5 F2Z3W5_MOUSE Gm11237 Gm38423 Msantd5f5 NM_001277575 uc290nhq.1 uc290nhq.2 This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is inferred from alignment of paralogous transcripts. [provided by RefSeq, Apr 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignment of paralogous transcripts. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## molecular_function cellular_component biological_process uc290nhq.1 uc290nhq.2 
ENSMUST00000178327.2 ENSMUSG00000094855 ENSMUST00000178327.2 ENSMUSG00000094855 (from geneSymbol) ENSMUST00000178327.1 uc291cfu.1 uc291cfu.2 uc291cfu.1 uc291cfu.2 
ENSMUST00000178328.8 Gyg1 ENSMUST00000178328.8 glycogenin 1, transcript variant 2 (from RefSeq NM_013755.5) ENSMUST00000178328.1 ENSMUST00000178328.2 ENSMUST00000178328.3 ENSMUST00000178328.4 ENSMUST00000178328.5 ENSMUST00000178328.6 ENSMUST00000178328.7 GLYG_MOUSE Gyg Gyg1 NM_013755 Q3TWR9 Q9R062 uc290ebp.1 uc290ebp.2 Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It self- glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. Reaction=L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D- glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP; Xref=Rhea:RHEA:23360, Rhea:RHEA-COMP:14604, Rhea:RHEA-COMP:14605, ChEBI:CHEBI:15378, ChEBI:CHEBI:46858, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885, ChEBI:CHEBI:140573; EC=2.4.1.186; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23361; Evidence= Reaction=[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha- D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP; Xref=Rhea:RHEA:56560, Rhea:RHEA-COMP:14606, Rhea:RHEA- COMP:14607, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885, ChEBI:CHEBI:140574; EC=2.4.1.186; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56561; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Divalent metal ions. Required for self-glucosylation. Manganese is the most effective. ; Glycan biosynthesis; glycogen biosynthesis. Part of the GYS1-GYG1 complex, a heterooctamer composed of a tetramer of GYS1 and 2 dimers of GYG1, where each GYS1 protomer binds to one GYG1 subunit (via GYG1 C-terminus); the GYS1 tetramer may dissociate from GYG1 dimers to continue glycogen polymerization on its own (By similarity). May also form a heterooctamer complex with GYS2 (Probable). Skeletal muscle, heart, to a lesser extent in kidney, lung and brain. Self-glycosylated by the transfer of glucose residues from UDP- glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-195. Phosphorylated. Belongs to the glycosyltransferase 8 family. Glycogenin subfamily. glucose binding glycogen biosynthetic process glycogenin glucosyltransferase activity transferase activity transferase activity, transferring glycosyl groups manganese ion binding protein homodimerization activity metal ion binding uc290ebp.1 uc290ebp.2 
ENSMUST00000178335.2 ENSMUSG00000095505 ENSMUST00000178335.2 ENSMUSG00000095505 (from geneSymbol) AA792892 AK053948 ENSMUST00000178335.1 Pramel52-ps Q8C6S1 Q8C6S1_MOUSE uc291cfd.1 uc291cfd.2 molecular_function cytoplasm biological_process uc291cfd.1 uc291cfd.2 
ENSMUST00000178337.2 Gm16367 ENSMUST00000178337.2 predicted gene 16367 (from RefSeq NM_001031622.3) AU018829 ENSMUST00000178337.1 Gm16367 NM_001031622 Q3UL49 Q3UL49_MOUSE uc291cfo.1 uc291cfo.2 Belongs to the PRAME family. molecular_function cellular_component biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc291cfo.1 uc291cfo.2 
ENSMUST00000178342.8 Samt1 ENSMUST00000178342.8 spermatogenesis associated multipass transmembrane protein 1 (from RefSeq NM_030036.1) 4921511M17Rik A2BED8 A2BED8_MOUSE ENSMUST00000178342.1 ENSMUST00000178342.2 ENSMUST00000178342.3 ENSMUST00000178342.4 ENSMUST00000178342.5 ENSMUST00000178342.6 ENSMUST00000178342.7 Gm10057 Gm5645 NM_030036 Samt1 Samt1b Samt1c uc009urd.1 uc009urd.2 uc009urd.3 uc009urd.4 molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc009urd.1 uc009urd.2 uc009urd.3 uc009urd.4 
ENSMUST00000178344.3 Itpripl2 ENSMUST00000178344.3 inositol 1,4,5-triphosphate receptor interacting protein-like 2 (from RefSeq NM_001033380.3) B2RX24 ENSMUST00000178344.1 ENSMUST00000178344.2 IPIL2_MOUSE NM_001033380 Q3UE60 Q3UV16 uc009jjx.1 uc009jjx.2 uc009jjx.3 Membrane; Single-pass type I membrane protein. Belongs to the ITPRIP family. Sequence=BAE29051.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc009jjx.1 uc009jjx.2 uc009jjx.3 
ENSMUST00000178347.3 Gm13275 ENSMUST00000178347.3 predicted gene 13275 (from RefSeq NM_001085533.2) B1AYI8 B1AYI8_MOUSE ENSMUST00000178347.1 ENSMUST00000178347.2 Gm13275 If1ha6 NM_001085533 uc008tnt.1 uc008tnt.2 uc008tnt.3 uc008tnt.4 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tnt.1 uc008tnt.2 uc008tnt.3 uc008tnt.4 
ENSMUST00000178355.3 Nupr2 ENSMUST00000178355.3 nuclear protein transcriptional regulator 2, transcript variant 2 (from RefSeq NM_026916.3) ENSMUST00000178355.1 ENSMUST00000178355.2 NM_026916 NUPR2_MOUSE Nupr1l Nupr2 Q3UXQ0 Q497P3 Q9D923 uc291aek.1 uc291aek.2 Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells. Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation of pancreatic cancer cells. Plays a role as a negative regulator of the protumoral factor NUPR1. Nucleus Belongs to the NUPR family. Sequence=BAB25026.1; Type=Frameshift; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleus cellular response to DNA damage stimulus cell cycle cell cycle arrest negative regulation of cell proliferation cellular response to starvation negative regulation of cell cycle negative regulation of cell cycle arrest uc291aek.1 uc291aek.2 
ENSMUST00000178384.2 Moap1 ENSMUST00000178384.2 modulator of apoptosis 1, transcript variant 2 (from RefSeq NM_001142937.2) ENSMUST00000178384.1 MOAP1_MOUSE Moap1 NM_001142937 Q9ERH6 uc011yqp.1 uc011yqp.2 uc011yqp.3 uc011yqp.4 Retrotransposon-derived protein that forms virion-like capsids (PubMed:34413232). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (By similarity). Required for death receptor-dependent apoptosis (By similarity). When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (By similarity). Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins (PubMed:33783314). Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (By similarity). Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction. Interacts with BAX. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX. Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization. Interacts with TRIM39 (By similarity). Interacts with RASSF6 (PubMed:17404571). Interacts with ATG8 proteins MAP1LC3A, MAP1LC3B and MAP1LC3C (By similarity). Does not interact with ATG8 proteins GABARAPL1, GABARAPL2 and GABARAP (By similarity). Interacts with SQSTM1; promoting dissociation of SQSTM1 inclusion bodies that sequester KEAP1 (By similarity). Cytoplasm, cytosol Mitochondrion outer membrane Extracellular vesicle membrane Note=Forms virion-like extracellular vesicles that are released from cells. Widely expressed, including in the brain. High expression levels in testis. The protein is evolutionarily related to retrotransposon Gag proteins: it contains the capsid (CA)subdomain of gag. The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction. The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins MAP1LC3A, MAP1LC3B and MAP1LC3C. Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39. Belongs to the PNMA family. protein insertion into mitochondrial membrane involved in apoptotic signaling pathway protein binding nucleus cytoplasm mitochondrion mitochondrial outer membrane cytosol apoptotic process extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage ubiquitin protein ligase binding regulation of apoptotic process positive regulation of apoptotic process positive regulation of release of cytochrome c from mitochondria apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand uc011yqp.1 uc011yqp.2 uc011yqp.3 uc011yqp.4 
ENSMUST00000178390.2 Astx4c ENSMUST00000178390.2 Astx4c (from geneSymbol) DQ874390 ENSMUST00000178390.1 uc292qjn.1 uc292qjn.2 uc292qjn.1 uc292qjn.2 
ENSMUST00000178422.9 Dapk3 ENSMUST00000178422.9 death-associated protein kinase 3, transcript variant 1 (from RefSeq NM_001190474.1) Dapk3 ENSMUST00000178422.1 ENSMUST00000178422.2 ENSMUST00000178422.3 ENSMUST00000178422.4 ENSMUST00000178422.5 ENSMUST00000178422.6 ENSMUST00000178422.7 ENSMUST00000178422.8 NM_001190474 Q05A21 Q05A21_MOUSE uc007ggh.1 uc007ggh.2 uc007ggh.3 uc007ggh.4 uc007ggh.5 Belongs to the protein kinase superfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm actin filament protein phosphorylation apoptotic process regulation of mitotic cell cycle protein C-terminus binding kinase activity phosphorylation Rho GTPase binding negative regulation of translation neuron differentiation intracellular signal transduction identical protein binding protein homodimerization activity positive regulation of apoptotic process leucine zipper domain binding membrane raft protein autophosphorylation regulation of focal adhesion assembly cellular response to interferon-gamma positive regulation of canonical Wnt signaling pathway regulation of actin cytoskeleton reorganization positive regulation of extrinsic apoptotic signaling pathway in absence of ligand uc007ggh.1 uc007ggh.2 uc007ggh.3 uc007ggh.4 uc007ggh.5 
ENSMUST00000178424.3 Gm21859 ENSMUST00000178424.3 Gm21859 (from geneSymbol) BC082544 ENSMUST00000178424.1 ENSMUST00000178424.2 uc007yem.1 uc007yem.2 uc007yem.3 uc007yem.4 uc007yem.1 uc007yem.2 uc007yem.3 uc007yem.4 
ENSMUST00000178426.4 Trav9d-1 ENSMUST00000178426.4 Trav9d-1 (from geneSymbol) A0A075B699 A0A075B699_MOUSE ENSMUST00000178426.1 ENSMUST00000178426.2 ENSMUST00000178426.3 M76612 Trav9d-1 uc288twt.1 uc288twt.2 uc288twt.1 uc288twt.2 
ENSMUST00000178438.3 Potefam3b ENSMUST00000178438.3 POTE ankyrin domain family member 3B (from RefSeq NM_001270553.1) ENSMUST00000178438.1 ENSMUST00000178438.2 NM_001270553 Potefam3b Q8C646 Q8C646_MOUSE uc029wrm.1 uc029wrm.2 uc029wrm.3 uc029wrm.1 uc029wrm.2 uc029wrm.3 
ENSMUST00000178443.2 Zfp967 ENSMUST00000178443.2 zinc finger protein 967, transcript variant 1 (from RefSeq NM_001177406.1) A2ART2 A2ART2_MOUSE ENSMUST00000178443.1 NM_001177406 Zfp966 Zfp967 Zfp968 Zfp969 uc029uiw.1 uc029uiw.2 uc029uiw.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc029uiw.1 uc029uiw.2 uc029uiw.3 
ENSMUST00000178446.3 Gm20837 ENSMUST00000178446.3 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRF5) 1700040F15Rik A0A087WRF5 A0A087WRF5_MOUSE AK077064 ENSMUST00000178446.1 ENSMUST00000178446.2 Gm20792 Gm20837 Gm20838 Gm21094 Gm21256 Gm21739 Gm21861 Gm28891 uc292vae.1 uc292vae.2 uc292vae.3 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc292vae.1 uc292vae.2 uc292vae.3 
ENSMUST00000178459.3 Spin2h ENSMUST00000178459.3 Belongs to the SPIN/STSY family. (from UniProt E9PWJ8) A0A140T8V2 E9PWJ8 E9PWJ8_MOUSE ENSMUST00000178459.1 ENSMUST00000178459.2 Spin2h Spin2j uc292nqk.1 uc292nqk.2 uc292nqk.3 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation biological_process methylated histone binding uc292nqk.1 uc292nqk.2 uc292nqk.3 
ENSMUST00000178461.3 Gm22549 ENSMUST00000178461.3 Gm22549 (from geneSymbol) ENSMUST00000178461.1 ENSMUST00000178461.2 uc287kcp.1 uc287kcp.2 uc287kcp.1 uc287kcp.2 
ENSMUST00000178465.3 Fmo6 ENSMUST00000178465.3 flavin containing monooxygenase 6 (from RefSeq NM_001178038.1) ENSMUST00000178465.1 ENSMUST00000178465.2 Fmo6 J3QMN6 J3QMN6_MOUSE NM_001178038 uc011wur.1 uc011wur.2 uc011wur.3 Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= Endoplasmic reticulum membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein Microsome membrane ; Single-pass membrane protein Belongs to the FMO family. monooxygenase activity N,N-dimethylaniline monooxygenase activity cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane oxidoreductase activity organelle membrane intracellular membrane-bounded organelle flavin adenine dinucleotide binding NADP binding oxidation-reduction process uc011wur.1 uc011wur.2 uc011wur.3 
ENSMUST00000178466.2 ENSMUSG00000095666 ENSMUST00000178466.2 ENSMUSG00000095666 (from geneSymbol) AK145597 ENSMUST00000178466.1 uc291cfb.1 uc291cfb.2 uc291cfb.1 uc291cfb.2 
ENSMUST00000178473.8 Faap20 ENSMUST00000178473.8 Fanconi anemia core complex associated protein 20, transcript variant 1 (from RefSeq NM_001190445.1) A2ADD8 ENSMUST00000178473.1 ENSMUST00000178473.2 ENSMUST00000178473.3 ENSMUST00000178473.4 ENSMUST00000178473.5 ENSMUST00000178473.6 ENSMUST00000178473.7 FAP20_MOUSE Faap20 NM_001190445 Q0VG17 Q3UN58 uc008wda.1 uc008wda.2 uc008wda.3 Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys- 63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1 (By similarity). Component of the Fanconi anemia (FA) complex. Interacts with FANCA; interaction is direct. Interacts with REV1 (By similarity). Nucleus Chromosome Note=Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UN58-1; Sequence=Displayed; Name=2; IsoId=Q3UN58-2; Sequence=VSP_030817; Name=3; IsoId=Q3UN58-3; Sequence=VSP_030818; The UBZ2-type zinc finger binds both 'Lys-48'- and 'Lys-63'- linked polyubiquitin with preference for 'Lys-63'-linked polyubiquitin. nucleus nucleoplasm chromosome DNA repair cellular response to DNA damage stimulus nuclear body translesion synthesis cell junction polyubiquitin binding interstrand cross-link repair ubiquitin binding Fanconi anaemia nuclear complex metal ion binding K63-linked polyubiquitin binding uc008wda.1 uc008wda.2 uc008wda.3 
ENSMUST00000178475.3 Gm22070 ENSMUST00000178475.3 Gm22070 (from geneSymbol) DQ558729 ENSMUST00000178475.1 ENSMUST00000178475.2 uc287uxk.1 uc287uxk.2 uc287uxk.1 uc287uxk.2 
ENSMUST00000178480.3 Gm13277 ENSMUST00000178480.3 predicted gene 13277 (from RefSeq NM_001098840.3) B1AYI0 ENSMUST00000178480.1 ENSMUST00000178480.2 Gm13277 Gm13278 Gm13279 Gm13288 Gm13289 Gm13290 NM_001098840 Q8CD73 Q8CD73_MOUSE uc008tnr.1 uc008tnr.2 uc008tnr.3 uc008tnr.4 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tnr.1 uc008tnr.2 uc008tnr.3 uc008tnr.4 
ENSMUST00000178483.2 Ighd5-7 ENSMUST00000178483.2 Ighd5-7 (from geneSymbol) A0A0G2JDD5 A0A0G2JDD5_MOUSE ENSMUST00000178483.1 Gm37327 Ighd5-7 Ighd5-8 uc288jso.1 uc288jso.2 uc288jso.1 uc288jso.2 
ENSMUST00000178485.8 1700003H04Rik ENSMUST00000178485.8 RIKEN cDNA 1700003H04 gene, transcript variant 1 (from RefSeq NM_001368235.1) 1700003H04Rik ENSMUST00000178485.1 ENSMUST00000178485.2 ENSMUST00000178485.3 ENSMUST00000178485.4 ENSMUST00000178485.5 ENSMUST00000178485.6 ENSMUST00000178485.7 J3QNW2 J3QNW2_MOUSE NM_001368235 uc012cxf.1 uc012cxf.2 uc012cxf.3 GTPase activator activity cellular_component positive regulation of GTPase activity uc012cxf.1 uc012cxf.2 uc012cxf.3 
ENSMUST00000178489.2 Gm13043 ENSMUST00000178489.2 predicted gene 13043 (from RefSeq NM_001039595.2) ENSMUST00000178489.1 Gm13040 Gm13043 Gm13057 NM_001039595 OTTMUSG00000010136 Q4FZF9 Q4FZF9_MOUSE uc008vqh.1 uc008vqh.2 uc008vqh.3 uc008vqh.4 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008vqh.1 uc008vqh.2 uc008vqh.3 uc008vqh.4 
ENSMUST00000178490.3 Gm25546 ENSMUST00000178490.3 Gm25546 (from geneSymbol) ENSMUST00000178490.1 ENSMUST00000178490.2 uc288yah.1 uc288yah.2 uc288yah.1 uc288yah.2 
ENSMUST00000178498.2 Esp4 ENSMUST00000178498.2 exocrine gland secreted peptide 4 (from RefSeq NM_001177583.1) A8R0T8 A8R0T8_MOUSE ENSMUST00000178498.1 Esp4 Gm20580 NM_001177583 uc012atk.1 uc012atk.2 uc012atk.3 pheromone activity extracellular space biological_process uc012atk.1 uc012atk.2 uc012atk.3 
ENSMUST00000178504.8 Atp9a ENSMUST00000178504.8 Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling, probably acting through RAB5 and RAB11 activation (PubMed:36604604). Also involved in endosome to trans-Golgi network retrograde transport (By similarity). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation. Appears to be implicated in intercellular communication by negatively regulating the release of exosomes. The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved. Required for the maintenance of neurite morphology and synaptic transmission (PubMed:36604604). (from UniProt O70228) AF152243 ATP9A_MOUSE ENSMUST00000178504.1 ENSMUST00000178504.2 ENSMUST00000178504.3 ENSMUST00000178504.4 ENSMUST00000178504.5 ENSMUST00000178504.6 ENSMUST00000178504.7 O70228 Q8VDI5 Q922L9 uc290cvb.1 uc290cvb.2 Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling, probably acting through RAB5 and RAB11 activation (PubMed:36604604). Also involved in endosome to trans-Golgi network retrograde transport (By similarity). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation. Appears to be implicated in intercellular communication by negatively regulating the release of exosomes. The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved. Required for the maintenance of neurite morphology and synaptic transmission (PubMed:36604604). Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Heterotrimer with MON2 and DOP1B; this complex regulates SNX3- retromer mediated endosomal sorting of WLS. Interacts with RAB5A and RAB11A. Early endosome membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Late endosome membrane Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B. Transiently expressed in the cell membrane. Found in most tissues except spleen. Also detected in fetal tissues. Expressed in brain (PubMed:36604604). ATP9A knock down results in muscle weakness, memory impairment and hyperkinetic movement disorders. Abnormal neurite morphology and impaired synaptic transmission are found in the primary motor cortex and hippocampus of knocked-down mice. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. nucleotide binding magnesium ion binding ATP binding endosome early endosome Golgi apparatus trans-Golgi network plasma membrane retrograde vesicle-mediated transport, Golgi to ER endocytosis phospholipid transport membrane integral component of membrane early endosome membrane phospholipid translocation metal ion binding perinuclear region of cytoplasm recycling endosome uc290cvb.1 uc290cvb.2 
ENSMUST00000178532.2 Esp23 ENSMUST00000178532.2 exocrine gland secreted peptide 23 (from RefSeq NM_001177582.1) A8R0V5 A8R0V5_MOUSE ENSMUST00000178532.1 Esp23 Gm20581 NM_001177582 uc012atf.1 uc012atf.2 pheromone activity extracellular space biological_process uc012atf.1 uc012atf.2 
ENSMUST00000178533.2 Cwc22rt5 ENSMUST00000178533.2 Nucleus speckle (from UniProt A2AK42) A2AK42 A2AK42_MOUSE Cwc22rt1 Cwc22rt2 Cwc22rt4 Cwc22rt5 Cwc22rt6 Cwc22rt7 ENSMUST00000178533.1 uc289xkc.1 uc289xkc.2 Nucleus speckle Belongs to the CWC22 family. mRNA splicing, via spliceosome RNA binding catalytic step 2 spliceosome uc289xkc.1 uc289xkc.2 
ENSMUST00000178536.2 Gm24317 ENSMUST00000178536.2 Gm24317 (from geneSymbol) DQ558729 ENSMUST00000178536.1 uc290lhk.1 uc290lhk.2 uc290lhk.1 uc290lhk.2 
ENSMUST00000178537.2 Trbd1 ENSMUST00000178537.2 Trbd1 (from geneSymbol) ENSMUST00000178537.1 uc291dvi.1 uc291dvi.2 uc291dvi.1 uc291dvi.2 
ENSMUST00000178540.9 1700028I16Rik ENSMUST00000178540.9 1700028I16Rik (from geneSymbol) AK006461 ENSMUST00000178540.1 ENSMUST00000178540.2 ENSMUST00000178540.3 ENSMUST00000178540.4 ENSMUST00000178540.5 ENSMUST00000178540.6 ENSMUST00000178540.7 ENSMUST00000178540.8 uc007gjx.1 uc007gjx.2 uc007gjx.3 uc007gjx.1 uc007gjx.2 uc007gjx.3 
ENSMUST00000178545.3 Tmem200c ENSMUST00000178545.3 transmembrane protein 200C (from RefSeq NM_001206661.2) ENSMUST00000178545.1 ENSMUST00000178545.2 J3QK46 J3QK46_MOUSE NM_001206661 Tmem200c uc029tkm.1 uc029tkm.2 uc029tkm.3 Membrane ; Multi- pass membrane protein Belongs to the TMEM200 family. molecular_function cellular_component biological_process membrane integral component of membrane uc029tkm.1 uc029tkm.2 uc029tkm.3 
ENSMUST00000178549.2 Ighd2-5 ENSMUST00000178549.2 Ighd2-5 (from geneSymbol) ENSMUST00000178549.1 uc288jsq.1 uc288jsq.2 uc288jsq.1 uc288jsq.2 
ENSMUST00000178565.3 Gm25633 ENSMUST00000178565.3 Gm25633 (from geneSymbol) ENSMUST00000178565.1 ENSMUST00000178565.2 uc292hcj.1 uc292hcj.2 uc292hcj.1 uc292hcj.2 
ENSMUST00000178569.2 ENSMUSG00000095019 ENSMUST00000178569.2 ENSMUSG00000095019 (from geneSymbol) ENSMUST00000178569.1 uc292var.1 uc292var.2 uc292var.1 uc292var.2 
ENSMUST00000178573.8 Wdr53 ENSMUST00000178573.8 WD repeat domain 53, transcript variant 2 (from RefSeq NM_001185162.2) ENSMUST00000178573.1 ENSMUST00000178573.2 ENSMUST00000178573.3 ENSMUST00000178573.4 ENSMUST00000178573.5 ENSMUST00000178573.6 ENSMUST00000178573.7 NM_001185162 Q9DB94 WDR53_MOUSE uc012aej.1 uc012aej.2 uc012aej.3 Belongs to the WD repeat WDR53 family. molecular_function biological_process uc012aej.1 uc012aej.2 uc012aej.3 
ENSMUST00000178578.4 Gm5885 ENSMUST00000178578.4 Gm5885 (from geneSymbol) ENSMUST00000178578.1 ENSMUST00000178578.2 ENSMUST00000178578.3 uc012euh.1 uc012euh.2 uc012euh.3 uc012euh.1 uc012euh.2 uc012euh.3 
ENSMUST00000178581.2 Krtap10-34 ENSMUST00000178581.2 predicted gene, 19668 (from RefSeq NM_001205034.2) ENSMUST00000178581.1 Gm19668 J3QMD1 J3QMD1_MOUSE NM_001205034 uc029qzq.1 uc029qzq.2 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the PMG family. intermediate filament keratin filament uc029qzq.1 uc029qzq.2 
ENSMUST00000178584.2 Gm21817 ENSMUST00000178584.2 Gm21817 (from geneSymbol) BC024873 ENSMUST00000178584.1 uc292caz.1 uc292caz.2 uc292caz.1 uc292caz.2 
ENSMUST00000178595.2 H2al1d ENSMUST00000178595.2 H2A histone family member L1D (from RefSeq NM_001242950.1) ENSMUST00000178595.1 H2AL1_MOUSE H2al1a H2al1c H2al1d H2al1f H2al1g H2al1h H2al1i NM_001242950 Q5M8Q2 uc029xie.1 uc029xie.2 uc029xie.3 Atypical histone H2A which can replace conventional H2A in some nucleosomes and may play a role during spermatogenesis. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes, replacing one or more H2A molecules. Interacts with H2BC1/TH2B; preferentially dimerizes with H2BC1/TH2B to form nucleosomes (PubMed:17261847). Nucleus Chromosome Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847). Testis-specific. Strongly enriched in step 12-16 spermatids and accumulate during late spermiogenesis, in condensing spermatids (PubMed:17261847). Remains present in mature spermatozoa isolated from epididymis (PubMed:17261847). Rapidly disappears from the paternal pericentric heterochromatin regions after sperm-egg fusion (PubMed:18703863). In contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding protein binding nucleus chromosome pericentric heterochromatin DNA packaging chromatin organization spermatogenesis cell differentiation DNA packaging complex protein heterodimerization activity uc029xie.1 uc029xie.2 uc029xie.3 
ENSMUST00000178597.3 Tmem95 ENSMUST00000178597.3 transmembrane protein 95 (from RefSeq NM_001195710.2) ENSMUST00000178597.1 ENSMUST00000178597.2 NM_001195710 P0DJF3 TMM95_MOUSE Tmem95 uc011xxc.1 uc011xxc.2 uc011xxc.3 Sperm protein required for fusion of sperm with the egg membrane during fertilization. Does not interact with sperm-egg fusion proteins IZUMO1 or IZUMO1R/JUNO. Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Single-pass type I membrane protein Note=Following the acrosome reaction, relocalizes to the equatorial segment. Expressed exclusively in testis. Expression is first detected at postnatal day 21. Males are healthy, grossly normal and exhibit normal mating behavior but are infertile (PubMed:32484434, PubMed:32393636). Sperm are morphologically normal, exhibit normal motility and can penetrate the zona pellucida and bind to the oolemma but are unable to fuse with the egg membrane or penetrate into the ooplasm (PubMed:32484434, PubMed:32393636). No effect on location of sperm-egg fusion protein IZUMO1 (PubMed:32393636). Belongs to the TMEM95 family. molecular_function cellular_component biological_process membrane integral component of membrane uc011xxc.1 uc011xxc.2 uc011xxc.3 
ENSMUST00000178599.7 Gm21454 ENSMUST00000178599.7 Belongs to the SPIN/STSY family. (from UniProt J3QPX2) ENSMUST00000178599.1 ENSMUST00000178599.2 ENSMUST00000178599.3 ENSMUST00000178599.4 ENSMUST00000178599.5 ENSMUST00000178599.6 Gm21454 J3QPX2 J3QPX2_MOUSE Ssty1 X05260 uc292shc.1 uc292shc.2 Belongs to the SPIN/STSY family. gamete generation uc292shc.1 uc292shc.2 
ENSMUST00000178602.3 Gm13279 ENSMUST00000178602.3 predicted gene 13279 (from RefSeq NM_001243166.1) B1AYI0 ENSMUST00000178602.1 ENSMUST00000178602.2 Gm13277 Gm13278 Gm13279 Gm13288 Gm13289 Gm13290 NM_001243166 Q8CD73 Q8CD73_MOUSE uc008tnu.1 uc008tnu.2 uc008tnu.3 uc008tnu.4 uc008tnu.5 uc008tnu.6 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tnu.1 uc008tnu.2 uc008tnu.3 uc008tnu.4 uc008tnu.5 uc008tnu.6 
ENSMUST00000178603.2 ENSMUSG00000095672 ENSMUST00000178603.2 ENSMUSG00000095672 (from geneSymbol) AK139759 ENSMUST00000178603.1 uc289spg.1 uc289spg.2 uc289spg.1 uc289spg.2 
ENSMUST00000178608.2 Astx1b ENSMUST00000178608.2 Astx1b (from geneSymbol) DQ874390 ENSMUST00000178608.1 uc292qji.1 uc292qji.2 uc292qji.1 uc292qji.2 
ENSMUST00000178614.3 Odaph ENSMUST00000178614.3 odontogenesis associated phosphoprotein (from RefSeq NM_001177577.1) ENSMUST00000178614.1 ENSMUST00000178614.2 Gm1045 J3QNT8 J3QNT8_MOUSE NM_001177577 Odaph uc012dyk.1 uc012dyk.2 uc012dyk.3 molecular_function cellular_component positive regulation of biomineral tissue development positive regulation of enamel mineralization uc012dyk.1 uc012dyk.2 uc012dyk.3 
ENSMUST00000178621.2 Btbd35f10 ENSMUST00000178621.2 BTB domain containing 35, family member 10 (from RefSeq NM_001085552.2) A2CG92 A2CG92_MOUSE Btbd35f10 ENSMUST00000178621.1 Gm14351 NM_001085552 uc009skl.1 uc009skl.2 uc009skl.3 uc009skl.4 molecular_function cellular_component biological_process uc009skl.1 uc009skl.2 uc009skl.3 uc009skl.4 
ENSMUST00000178628.9 1700001L05Rik ENSMUST00000178628.9 1700001L05Rik (from geneSymbol) BC099567 ENSMUST00000178628.1 ENSMUST00000178628.2 ENSMUST00000178628.3 ENSMUST00000178628.4 ENSMUST00000178628.5 ENSMUST00000178628.6 ENSMUST00000178628.7 ENSMUST00000178628.8 uc007xay.1 uc007xay.2 uc007xay.3 uc007xay.4 uc007xay.1 uc007xay.2 uc007xay.3 uc007xay.4 
ENSMUST00000178630.2 Calhm3 ENSMUST00000178630.2 Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP (PubMed:29681531). Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (PubMed:29681531). CALHM1-CALHM3- mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances (PubMed:29681531). (from UniProt J3QMI4) CAHM3_MOUSE Calhm3 ENSMUST00000178630.1 J3QMI4 LC270871 uc289sho.1 uc289sho.2 Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP (PubMed:29681531). Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (PubMed:29681531). CALHM1-CALHM3- mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances (PubMed:29681531). Associates with CALHM1 as a pore-forming subunit in an hetero- hexameric channel complex. Basolateral cell membrane ; Multi-pass membrane protein Note=Localizes to the basolateral membrane of epithelial cells including taste cells. Expressed in taste bud cells. Genetic deletion eliminates voltage-gated nonselective currents and taste-evoked ATP release in type II TBCs without affecting cell excitability or diminishing Calhm1 expression, and results in the loss of responses to sweet, umami and bitter tastes. Belongs to the CALHM family. integral component of plasma membrane membrane integral component of membrane uc289sho.1 uc289sho.2 
ENSMUST00000178632.8 Bex3 ENSMUST00000178632.8 brain expressed X-linked 3, transcript variant 1 (from RefSeq NM_009750.2) A3KGA0 A3KGA1 BEX3_MOUSE Bex3 ENSMUST00000178632.1 ENSMUST00000178632.2 ENSMUST00000178632.3 ENSMUST00000178632.4 ENSMUST00000178632.5 ENSMUST00000178632.6 ENSMUST00000178632.7 NM_009750 Nade Ngfrap1 Q9CWN9 Q9D0S2 Q9D1N5 Q9WTZ9 uc012hov.1 uc012hov.2 May be a signaling adapter molecule involved in NGFR/p75NTR- mediated apoptosis induced by NGF (PubMed:10764727). Plays a role in zinc-triggered neuronal death (PubMed:10764727). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (PubMed:34562363). Self-associates (PubMed:11830582). Binds to the DEATH domain of p75NTR/NGFR (PubMed:11830582). Interacts with 14-3-3 epsilon (YWHAE) (PubMed:11278287). Interacts with DIABLO/SMAC (PubMed:15178455). Nucleus Cytoplasm, cytosol Note=Shuttles between the cytoplasm and the nucleus (PubMed:11830582). Associates with replicating mitochondria (PubMed:15563833). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WTZ9-1; Sequence=Displayed; Name=2; IsoId=Q9WTZ9-2; Sequence=VSP_017744; Widely expressed. The nuclear export signal is required for export from the nucleus and the interactions with itself and NGFR/p75NTR. The histidine cluster (His cluster) and Cys-121 mediate zinc- binding. Ubiquitinated (PubMed:10764727). Degraded by the proteasome (PubMed:10764727). Belongs to the BEX family. Sequence=BAB23350.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence=; death receptor binding nerve growth factor receptor binding nucleus cytoplasm cytosol apoptotic process extrinsic apoptotic signaling pathway via death domain receptors identical protein binding metal ion binding uc012hov.1 uc012hov.2 
ENSMUST00000178636.2 Larp1 ENSMUST00000178636.2 La ribonucleoprotein 1, translational regulator (from RefSeq NM_028451.1) A2AFQ8 ENSMUST00000178636.1 J3QNB1 Kiaa0731 LARP1_MOUSE Larp NM_028451 Q6ZQ58 Q7TSF7 uc007jah.1 uc007jah.2 uc007jah.3 uc007jah.4 RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis. Interacts with PABPC1/PABP. Interacts with EIF4A1. Interacts with RPTOR. Recruited to the active mTORC1 complex via interaction with RPTOR. Inhibition of mTORC1 activity strongly reduces interaction with RPTOR and the mTORC1 complex. Identified in a complex with mRNA, PABPC1, EIF4E and EIF4G1. Found in a complex with PABPC1 and SHFL. Cytoplasm Cytoplasmic granule Note=Colocalizes with RPTOR and PABPC1 in cytoplasmic granules that resemble stress granules. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZQ58-1; Sequence=Displayed; Name=2; IsoId=Q6ZQ58-2; Sequence=VSP_015116; At 10.5 dpc, expressed in dorsal root ganglia, spinal cord, and branchial arches. At 14.5 dpc, expressed in olfactory epithelium and cranial sensory ganglia. Also expressed in salivary glands, lungs, gut, kidney, teeth and vibrissae. The C-terminal region mediates interaction with the mRNA and polysomes. It is required for translational repression of mRNAs with a 5'TOP motif. The N-terminal region mediates interaction with PABPC1. Phosphorylated on multiple Ser and Thr residues in response to active mTORC1. Phosphorylation is important for interaction with RPTOR and the mTORC1 complex. Phosphorylation promotes dissociation from the 5'UTR of mRNA molecules with a 5'TOP motif. Belongs to the LARP family. Conflicting results are reported regarding the interaction with PABPC1. Some studies found that the interaction depends on the presence of mRNA; others found that the interaction is direct and does not depend on the presence of mRNA. RNA cap binding RNA 7-methylguanosine cap binding RNA binding mRNA 3'-UTR binding cytoplasm polysome translational initiation regulation of translation eukaryotic initiation factor 4E binding cell proliferation translation activator activity cytoplasmic stress granule positive regulation of macroautophagy negative regulation of translation translation initiation factor binding TOR signaling TORC1 complex TORC1 signaling polysomal ribosome ribosomal small subunit binding positive regulation of viral genome replication positive regulation of translation negative regulation of translational initiation mRNA 5'-UTR binding mRNA stabilization cellular response to rapamycin response to amino acid starvation uc007jah.1 uc007jah.2 uc007jah.3 uc007jah.4 
ENSMUST00000178644.2 Gm21969 ENSMUST00000178644.2 Gm21969 (from geneSymbol) AK044712 ENSMUST00000178644.1 Gm21969 J3QJZ1 J3QJZ1_MOUSE uc290rfk.1 uc290rfk.2 intermediate filament uc290rfk.1 uc290rfk.2 
ENSMUST00000178645.2 ENSMUSG00000094514 ENSMUST00000178645.2 ENSMUSG00000094514 (from geneSymbol) ENSMUST00000178645.1 uc289sph.1 uc289sph.2 uc289sph.1 uc289sph.2 
ENSMUST00000178650.3 Trav6d-7 ENSMUST00000178650.3 Trav6d-7 (from geneSymbol) A0A075B6B0 A0A075B6B0_MOUSE ENSMUST00000178650.1 ENSMUST00000178650.2 Trav6d-7 X52448 uc007tqr.1 uc007tqr.2 uc007tqr.3 uc007tqr.4 uc007tqr.5 uc007tqr.6 immunoglobulin production extracellular space immune response uc007tqr.1 uc007tqr.2 uc007tqr.3 uc007tqr.4 uc007tqr.5 uc007tqr.6 
ENSMUST00000178667.3 1700021P04Rik ENSMUST00000178667.3 1700021P04Rik (from geneSymbol) AK006227 ENSMUST00000178667.1 ENSMUST00000178667.2 uc289rla.1 uc289rla.2 uc289rla.3 uc289rla.1 uc289rla.2 uc289rla.3 
ENSMUST00000178678.8 Sncaip ENSMUST00000178678.8 synuclein, alpha interacting protein (synphilin), transcript variant 1 (from RefSeq NM_001199151.2) ENSMUST00000178678.1 ENSMUST00000178678.2 ENSMUST00000178678.3 ENSMUST00000178678.4 ENSMUST00000178678.5 ENSMUST00000178678.6 ENSMUST00000178678.7 G5E848 G5E848_MOUSE NM_001199151 Sncaip uc008exn.1 uc008exn.2 uc008exn.3 uc008exn.4 nucleoplasm cytoplasm cell death ubiquitin protein ligase binding cytoplasmic ribonucleoprotein granule dopamine metabolic process identical protein binding regulation of neurotransmitter secretion regulation of inclusion body assembly uc008exn.1 uc008exn.2 uc008exn.3 uc008exn.4 
ENSMUST00000178679.3 Topaz1 ENSMUST00000178679.3 testis and ovary specific PAZ domain containing 1 (from RefSeq NM_001199736.2) E5FYH1 ENSMUST00000178679.1 ENSMUST00000178679.2 Gm9524 NM_001199736 TOPZ1_MOUSE Topaz1 uc012hcy.1 uc012hcy.2 uc012hcy.3 Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear. Cytoplasm, cytosol Restricted to testis, where it localizes to germ cells. In both developing female and male gonads, first detected at 12.5 dpc, expression increases until 16.5 dpc and then drops (PubMed:22069478). Divergence between male and female expression starts around 5 days after birth (PubMed:22069478). In ovaries, expression decreases and becomes hardly detectable in adult ovaries, while in testis, expression increases 5 days after birth and becomes strong in the adult (PubMed:22069478). In both males and females, expression is restricted to germ cells (PubMed:22069478). In developing male germ cells, highly expressed at the spermatocyte stage; has little or no expression in round spermatids, elongated spermatids or spermatozoa (PubMed:26358182). Males are infertile, while female fertility is not affected. Testis size is significantly reduced with the phenotype apparent from postnatal day 28 (P28) onwards. Testicular histology appears to be normal before P28, but then cell aggregates begin to accumulate in the center of seminiferous tubules. Sperm development arrests at the post-meiotic round spermatid stage, associated with increased apoptosis. Adult testes completely lack round spermatids and spermatozoa. Meiosis appears to be normal up to the pachytene stage, with no apparent effect on synaptonemal complex formation or meiotic sex chromosome inactivation. However, chromosome alignment on the metaphase plate may be abnormal. In stage P20 testes, 99 gene transcripts show abnormal expression levels, including around 10 lincRNAs. molecular_function cellular_component cytoplasm cytosol apoptotic process spermatogenesis spermatid development cell differentiation spermatocyte division ncRNA transcription positive regulation of meiotic cell cycle phase transition uc012hcy.1 uc012hcy.2 uc012hcy.3 
ENSMUST00000178684.3 Pbld1 ENSMUST00000178684.3 phenazine biosynthesis-like protein domain containing 1, transcript variant 2 (from RefSeq NM_026701.3) ENSMUST00000178684.1 ENSMUST00000178684.2 Mawbp2 NM_026701 PBLD1_MOUSE Pbld Q8VCF3 Q9DCG6 uc007fju.1 uc007fju.2 uc007fju.3 uc007fju.4 Belongs to the PhzF family. catalytic activity cytoplasm biosynthetic process negative regulation of epithelial cell migration negative regulation of epithelial to mesenchymal transition isomerase activity maintenance of gastrointestinal epithelium negative regulation of transforming growth factor beta receptor signaling pathway identical protein binding negative regulation of epithelial cell proliferation negative regulation of SMAD protein import into nucleus negative regulation of pathway-restricted SMAD protein phosphorylation uc007fju.1 uc007fju.2 uc007fju.3 uc007fju.4 
ENSMUST00000178686.2 Mcl1 ENSMUST00000178686.2 Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity. (from UniProt P97287) BC003839 D2K6L9 ENSMUST00000178686.1 MCL1_MOUSE P97287 Q3TUS0 Q792P0 Q9CRI4 uc290hpx.1 uc290hpx.2 Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity. Interacts with HIF3A isoform 2 (via C-terminus domain) (PubMed:21546903). Interacts with BAD, BOK, BIK, BAX, BAK1, and TPT1. Interacts with BBC3, BMF and PMAIP1 (PubMed:15550399, PubMed:18589438). Interacts with BOP. Interacts with BCL2L11; this interaction may sequester BCL2L11 and prevent its pro-apoptotic activity (PubMed:16543145, PubMed:27013495, PubMed:15550399). Interacts with GIMAP5 and HSPA8/HSC70; the interaction between HSPA8 and MCL1 is impaired in the absence of GIMAP5 (PubMed:21502331). P97287; O08734: Bak1; NbExp=2; IntAct=EBI-707292, EBI-822441; P97287; Q99ML1: Bbc3; NbExp=2; IntAct=EBI-707292, EBI-727801; P97287; O54918: Bcl2l11; NbExp=5; IntAct=EBI-707292, EBI-526067; P97287; Q9JM54: Pmaip1; NbExp=14; IntAct=EBI-707292, EBI-709183; P97287; Q16611: BAK1; Xeno; NbExp=3; IntAct=EBI-707292, EBI-519866; P97287; Q07812: BAX; Xeno; NbExp=2; IntAct=EBI-707292, EBI-516580; P97287; Q9BXH1: BBC3; Xeno; NbExp=5; IntAct=EBI-707292, EBI-519884; P97287; O43521: BCL2L11; Xeno; NbExp=7; IntAct=EBI-707292, EBI-526406; Membrane ; Single-pass membrane protein Cytoplasm Mitochondrion. Nucleus, nucleoplasm Note=Cytoplasmic, associated with mitochondria. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P97287-1; Sequence=Displayed; Name=2; Synonyms=Mck-1V; IsoId=P97287-2; Sequence=VSP_046443; Up-regulated by IL3 and CSF2. Up-regulated in murine embryonal carcinoma cells in response to retinoic acid treatment. Levels reach a maximum after 4 hours, are decreased after 8 hours and are back to maximum after 12 hours. Levels are decreased after 24 hours and back to basal levels after 48 hours. Expression remains constant in retinoic acid-treated embryonic stem cells. Cleaved by CASP3 during apoptosis, yielding a pro-apoptotic C- terminal fragment. Rapidly degraded in the absence of phosphorylation in the PEST region. Phosphorylated on Ser-140, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-140 induces ubiquitination and proteasomal degradation, abrogating the anti- apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-140 (By similarity). Deubiquitinated by USP20; leading to increased stability. [Isoform 2]: This isoform is more stable than isoform 1 in cells undergoing apoptosis. Belongs to the Bcl-2 family. protein binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane cytosol apoptotic process multicellular organism development intrinsic apoptotic signaling pathway in response to DNA damage apoptotic mitochondrial changes negative regulation of autophagy membrane integral component of membrane cell differentiation response to cytokine protein homodimerization activity regulation of apoptotic process negative regulation of apoptotic process protein heterodimerization activity protein dimerization activity BH domain binding BH3 domain binding Bcl-2 family protein complex extrinsic apoptotic signaling pathway in absence of ligand positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of anoikis regulation of response to DNA damage stimulus negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway uc290hpx.1 uc290hpx.2 
ENSMUST00000178687.2 Tmem121b ENSMUST00000178687.2 transmembrane protein 121B (from RefSeq NM_033567.2) Cecr6 ENSMUST00000178687.1 NM_033567 Q99MX7 T121B_MOUSE Tmem121b uc009dnk.1 uc009dnk.2 Belongs to the TMEM121 family. uc009dnk.1 uc009dnk.2 
ENSMUST00000178691.2 Ubl4a ENSMUST00000178691.2 predicted readthrough transcript (NMD candidate), 44504, transcript variant 3 (from RefSeq NR_103489.1) ENSMUST00000178691.1 NR_103489 Q3UK94 Q3UK94_MOUSE RP23-436K3.13-001 uc012hkw.1 uc012hkw.2 uc012hkw.3 uc012hkw.4 This locus represents naturally occurring readthrough transcription between the neighboring Slc10a3 (solute carrier family 10 (sodium/bile acid cotransporter family), member 3) and Ubl4 (ubiquitin-like 4) genes on chromosome X. While some readthrough transcripts encode a protein that is identical to the downstream gene product, at least one readthrough transcript appears to be a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, May 2013]. Cytoplasm, cytosol nucleus nucleoplasm cytoplasm cytosol membrane chaperone binding tail-anchored membrane protein insertion into ER membrane BAT3 complex uc012hkw.1 uc012hkw.2 uc012hkw.3 uc012hkw.4 
ENSMUST00000178693.5 Asmt ENSMUST00000178693.5 acetylserotonin O-methyltransferase, transcript variant 2 (from RefSeq NM_001308488.2) A0A0R4J285 A0A0R4J285_MOUSE Asmt ENSMUST00000178693.1 ENSMUST00000178693.2 ENSMUST00000178693.3 ENSMUST00000178693.4 NM_001308488 uc029xop.1 uc029xop.2 uc029xop.3 This gene belongs to the methyltransferase superfamily and is located in the pseudoautosomal region (PAR) of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin and is abundant in the pineal gland. Two amino acid substitutions (R78G and R242C) are present in the encoded protein derived from the reference strain, C57BL/6J, and this protein shows low enzyme activity relative to the protein derived from other strains. [provided by RefSeq, May 2015]. Catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Reaction=N-acetylserotonin + S-adenosyl-L-methionine = H(+) + melatonin + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:15573, ChEBI:CHEBI:15378, ChEBI:CHEBI:16796, ChEBI:CHEBI:17697, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15574; Evidence=; Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2. methyltransferase activity O-methyltransferase activity methylation uc029xop.1 uc029xop.2 uc029xop.3 
ENSMUST00000178696.8 Wnt5b ENSMUST00000178696.8 wingless-type MMTV integration site family, member 5B, transcript variant 1 (from RefSeq NM_009525.4) ENSMUST00000178696.1 ENSMUST00000178696.2 ENSMUST00000178696.3 ENSMUST00000178696.4 ENSMUST00000178696.5 ENSMUST00000178696.6 ENSMUST00000178696.7 NM_009525 P22726 Q91XF5 WNT5B_MOUSE Wnt-5b uc009dmi.1 uc009dmi.2 uc009dmi.3 Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Interacts with PORCN. Secreted, extracellular space, extracellular matrix. Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. Belongs to the Wnt family. Sequence=AAA40568.1; Type=Erroneous initiation; Evidence=; Sequence=AAH10775.1; Type=Erroneous initiation; Evidence=; chondrocyte differentiation receptor binding frizzled binding extracellular region extracellular space endoplasmic reticulum lumen signal transduction cell-cell signaling multicellular organism development animal organ morphogenesis cell surface Wnt signaling pathway neuron differentiation positive regulation of cell migration extracellular matrix wound healing cell fate commitment positive regulation of fat cell differentiation negative regulation of canonical Wnt signaling pathway uc009dmi.1 uc009dmi.2 uc009dmi.3 
ENSMUST00000178699.2 Gm21844 ENSMUST00000178699.2 Gm21844 (from geneSymbol) ENSMUST00000178699.1 uc289qec.1 uc289qec.2 uc289qec.1 uc289qec.2 
ENSMUST00000178704.8 Ddc ENSMUST00000178704.8 dopa decarboxylase, transcript variant 5 (from RefSeq NM_001417459.1) Ddc ENSMUST00000178704.1 ENSMUST00000178704.2 ENSMUST00000178704.3 ENSMUST00000178704.4 ENSMUST00000178704.5 ENSMUST00000178704.6 ENSMUST00000178704.7 NM_001417459 Q5SUV8 Q5SUV8_MOUSE uc007iax.1 uc007iax.2 uc007iax.3 Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence= Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2. Homodimer. Belongs to the group II decarboxylase family. catalytic activity aromatic-L-amino-acid decarboxylase activity cytoplasm cellular amino acid metabolic process circadian rhythm synaptic vesicle multicellular organism aging aminergic neurotransmitter loading into synaptic vesicle amino acid binding lyase activity carboxy-lyase activity carboxylic acid metabolic process enzyme binding protein domain specific binding pyridoxal phosphate binding axon isoquinoline alkaloid metabolic process cellular response to drug L-dopa decarboxylase activity dopamine biosynthetic process serotonin biosynthetic process neuronal cell body response to pyrethroid phytoalexin metabolic process cellular response to alkaloid cellular response to growth factor stimulus uc007iax.1 uc007iax.2 uc007iax.3 
ENSMUST00000178747.3 Btbd35f5 ENSMUST00000178747.3 BTB domain containing 35, family member 5 (from RefSeq NM_001168337.1) Btbd35f1 E9QJS3 ENSMUST00000178747.1 ENSMUST00000178747.2 GMCL2_MOUSE Gmcl1l Gmcl1p1 Gmcl2 NM_001168337 Q99N64 Q99N65 Q99N66 Q9DA87 uc292nqf.1 uc292nqf.2 uc292nqf.3 Possible function in spermatogenesis. Probable substrate- specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Interacts with CUL3. Nucleus matrix molecular_function cellular_component nucleus multicellular organism development spermatogenesis biological_process nuclear matrix protein ubiquitination cell differentiation uc292nqf.1 uc292nqf.2 uc292nqf.3 
ENSMUST00000178756.8 Dpf3 ENSMUST00000178756.8 double PHD fingers 3, transcript variant 1 (from RefSeq NM_001267625.1) Baf45c Cerd4 DPF3_MOUSE ENSMUST00000178756.1 ENSMUST00000178756.2 ENSMUST00000178756.3 ENSMUST00000178756.4 ENSMUST00000178756.5 ENSMUST00000178756.6 ENSMUST00000178756.7 NM_001267625 P58269 Q80W78 Q8CAD8 uc007odc.1 uc007odc.2 uc007odc.3 uc007odc.4 Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development (By similarity). Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. [Isoform 2]: Acts as a regulator of myogenesis in cooperation with HDGFL2 (PubMed:32459350). Mediates the interaction of HDGFL2 with the BAF complex (PubMed:32459350). HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). In muscle cells, the BAF complex also contains DPF3 (By similarity). Interacts with acetylated histones H3 and H4 (By similarity). Component of neuron- specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (PubMed:17640523). [Isoform 2]: Interacts with HDGFL2 (PubMed:32459350). Interacts with SMARCA4/BRG1/BAF190A, SMARCC1/BAF155 and SMARCD1/BAF60A (By similarity). Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=DPF3b; IsoId=P58269-1; Sequence=Displayed; Name=2; Synonyms=DPF3a; IsoId=P58269-2; Sequence=VSP_035887; Name=3; IsoId=P58269-3; Sequence=VSP_035886, VSP_035887; Name=4; IsoId=P58269-4; Sequence=VSP_035885, VSP_035887; Expressed in the heart and somites. Expressed in cerebellum and spinal cord, but not in cerebral cortex. Expressed specifically in post-mitotic neurons (at protein level). First expressed in the first differentiating cardiomyocytes of the cardiac crescent at 7.5 dpc and in the first somites at 8.0 dpc. In the heart, expression is restricted to the myocardial compartment. In the developing forebrain and cerebellar primordium, strictly expressed in post-mitotic neurons. The PHD-type zinc fingers mediate the binding to acetylated histones. Belongs to the requiem/DPF family. histone acetyltransferase complex nuclear chromatin nucleic acid binding histone acetyltransferase activity nucleus nucleoplasm chromatin organization nervous system development zinc ion binding histone acetylation histone binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding nBAF complex uc007odc.1 uc007odc.2 uc007odc.3 uc007odc.4 
ENSMUST00000178767.3 Ccer2 ENSMUST00000178767.3 coiled-coil glutamate-rich protein 2 (from RefSeq NM_001195091.1) Ccer2 ENSMUST00000178767.1 ENSMUST00000178767.2 Gm6537 J3QPU5 J3QPU5_MOUSE NM_001195091 uc012fgw.1 uc012fgw.2 uc012fgw.3 uc012fgw.4 molecular_function cellular_component biological_process uc012fgw.1 uc012fgw.2 uc012fgw.3 uc012fgw.4 
ENSMUST00000178768.4 Trav7d-4 ENSMUST00000178768.4 Trav7d-4 (from geneSymbol) ENSMUST00000178768.1 ENSMUST00000178768.2 ENSMUST00000178768.3 M31647 Q5R1H9 Q5R1H9_MOUSE TRAV7D-4 Trav7d-4 uc007tpv.1 uc007tpv.2 uc007tpv.3 molecular_function cellular_component biological_process uc007tpv.1 uc007tpv.2 uc007tpv.3 
ENSMUST00000178772.3 Ankrd66 ENSMUST00000178772.3 ankyrin repeat domain 66, transcript variant 1 (from RefSeq NM_001404112.1) Ankrd66 D730048J04Rik ENSMUST00000178772.1 ENSMUST00000178772.2 J3QNN4 J3QNN4_MOUSE NM_001404112 uc029thx.1 uc029thx.2 uc029thx.3 uc029thx.1 uc029thx.2 uc029thx.3 
ENSMUST00000178806.2 H2al1c ENSMUST00000178806.2 H2A histone family member L1C (from RefSeq NM_001242949.1) ENSMUST00000178806.1 H2AL1_MOUSE H2al1a H2al1c H2al1d H2al1f H2al1g H2al1h H2al1i NM_001242949 Q5M8Q2 uc029xid.1 uc029xid.2 Atypical histone H2A which can replace conventional H2A in some nucleosomes and may play a role during spermatogenesis. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes, replacing one or more H2A molecules. Interacts with H2BC1/TH2B; preferentially dimerizes with H2BC1/TH2B to form nucleosomes (PubMed:17261847). Nucleus Chromosome Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847). Testis-specific. Strongly enriched in step 12-16 spermatids and accumulate during late spermiogenesis, in condensing spermatids (PubMed:17261847). Remains present in mature spermatozoa isolated from epididymis (PubMed:17261847). Rapidly disappears from the paternal pericentric heterochromatin regions after sperm-egg fusion (PubMed:18703863). In contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding protein binding nucleus chromosome pericentric heterochromatin DNA packaging chromatin organization spermatogenesis cell differentiation DNA packaging complex protein heterodimerization activity uc029xid.1 uc029xid.2 
ENSMUST00000178815.2 Ighd5-5 ENSMUST00000178815.2 Ighd5-5 (from geneSymbol) ENSMUST00000178815.1 uc288jsj.1 uc288jsj.2 uc288jsj.1 uc288jsj.2 
ENSMUST00000178823.2 1700122O11Rik ENSMUST00000178823.2 RIKEN cDNA 1700122O11 gene (from RefSeq NR_185296.1) 1700122O11Rik ENSMUST00000178823.1 J3QPW6 J3QPW6_MOUSE NR_185296 uc029tii.1 uc029tii.2 molecular_function cellular_component biological_process uc029tii.1 uc029tii.2 
ENSMUST00000178827.3 Btbd35f12 ENSMUST00000178827.3 BTB domain containing 35, family member 12 (from RefSeq NM_001099333.3) A0A0A0MQP3 A0A0A0MQP3_MOUSE Btbd35f12 ENSMUST00000178827.1 ENSMUST00000178827.2 Gm2863 NM_001099333 uc009swx.1 uc009swx.2 uc009swx.3 uc009swx.4 molecular_function cellular_component biological_process uc009swx.1 uc009swx.2 uc009swx.3 uc009swx.4 
ENSMUST00000178842.3 Gm23191 ENSMUST00000178842.3 Gm23191 (from geneSymbol) DQ558729 ENSMUST00000178842.1 ENSMUST00000178842.2 uc287uex.1 uc287uex.2 uc287uex.1 uc287uex.2 
ENSMUST00000178843.3 Lactbl1 ENSMUST00000178843.3 lactamase, beta-like 1 (from RefSeq NM_001243262.2) ENSMUST00000178843.1 ENSMUST00000178843.2 Lactbl1 NM_001243262 S4R213 S4R213_MOUSE uc029vaa.1 uc029vaa.2 uc029vaa.3 Mitochondrion Belongs to the beta-lactamase family. molecular_function cellular_component biological_process membrane integral component of membrane uc029vaa.1 uc029vaa.2 uc029vaa.3 
ENSMUST00000178852.3 Eif1ad11 ENSMUST00000178852.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. (from UniProt J3QQ02) ENSMUST00000178852.1 ENSMUST00000178852.2 Eif1ad11 J3QQ02 J3QQ02_MOUSE uc288ifk.1 uc288ifk.2 uc288ifk.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. molecular_function RNA binding translation initiation factor activity cellular_component translation translational initiation biological_process uc288ifk.1 uc288ifk.2 uc288ifk.3 
ENSMUST00000178858.3 Mymx ENSMUST00000178858.3 myomixer, myoblast fusion factor, transcript variant 1 (from RefSeq NM_001177468.1) E9PXI1 ENSMUST00000178858.1 ENSMUST00000178858.2 Gm7325 MYMX_MOUSE Mymx NM_001177468 Q2Q5T5 uc008crg.1 uc008crg.2 uc008crg.3 uc008crg.4 Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:28386024, PubMed:28569745, PubMed:28569755, PubMed:30197239). Involved in membrane fusion downstream of the lipid mixing step mediated by MYMK (PubMed:30197239). Acts by generating membrane stresses via its extracellular C-terminus, leading to drive fusion pore formation (PubMed:30197239). Acts independently of MYMK (PubMed:30197239). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (PubMed:29581287). Interacts with MYMK (PubMed:28386024). Cell membrane ingle-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=myomerger-short , S ; IsoId=Q2Q5T5-1; Sequence=Displayed; Name=2; Synonyms=myomerger-long , L ; IsoId=Q2Q5T5-2; Sequence=VSP_059105; Specifically expressed in developing skeletal muscles throughout the limbs and body wall (PubMed:28569745, PubMed:28569755, PubMed:28386024). Up-regulated during differentiation of myoblasts (PubMed:28569745, PubMed:28569755, PubMed:28386024). During muscle regeneration (PubMed:28569745, PubMed:28569755, PubMed:28386024). The AxLyCxL motif is required for myoblast fusion. Perinatal death due to a reduction in fused muscle fibers (PubMed:28569745). Embryos are motionless and lack skeletal muscle: they are nearly transparent so that internal organs and bones are apparent (PubMed:28386024). Myocytes differentiate and harbor organized sarcomeres but are fusion-incompetent (PubMed:28386024, PubMed:28569745, PubMed:28569755). Myoblast fusion is impaired downstream of membrane lipid mixing step mediated by Mymk and defects caused by the absence of Mymx are due to impaired fusion pore formation (PubMed:30197239). Conditional deletion in activated muscle stem cells (satellite cells) in adults abolishes satellite cell fusion and prevents muscle regeneration, resulting in severe muscle degeneration after injury (PubMed:29581287). Belongs to the MYMX family. Was initially reported to be specifically expressed in embryonic stem cells and germ cells (PubMed:16331322). However, it was later shown by different groups that it is specifically expressed in myoblasts where it promotes myoblast fusion (PubMed:28569745, PubMed:28569755, PubMed:28386024). Golgi membrane protein binding endoplasmic reticulum membrane plasma membrane integral component of plasma membrane muscle organ development myoblast fusion myoblast fusion involved in skeletal muscle regeneration membrane integral component of membrane skeletal muscle tissue regeneration plasma membrane fusion skeletal muscle organ development uc008crg.1 uc008crg.2 uc008crg.3 uc008crg.4 
ENSMUST00000178862.2 Trbd2 ENSMUST00000178862.2 Trbd2 (from geneSymbol) ENSMUST00000178862.1 uc291dvu.1 uc291dvu.2 uc291dvu.1 uc291dvu.2 
ENSMUST00000178864.3 Ccl21b ENSMUST00000178864.3 C-C motif chemokine ligand 21B (leucine), transcript variant 1 (from RefSeq NM_011335.3) CC21C_MOUSE Ccl21c ENSMUST00000178864.1 ENSMUST00000178864.2 NM_011335 O09002 O09006 P84443 P86793 Q5M8M5 Q91V84 Scya21c uc029usp.1 uc029usp.2 uc029usp.3 uc029usp.4 uc029usp.5 Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to CCR7 and to CXCR3. Interacts with PDPN; relocalizes PDPN to the basolateral membrane. Interacts with GPR174. Secreted. Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart. Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while Ccl21a has 'Ser-65' (6Ckine-Ser). Belongs to the intercrine beta (chemokine CC) family. monocyte chemotaxis cytokine activity extracellular region extracellular space chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway chemokine activity neutrophil chemotaxis CCR7 chemokine receptor binding chemokine receptor binding positive regulation of GTPase activity CCR chemokine receptor binding lymphocyte chemotaxis cell chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor uc029usp.1 uc029usp.2 uc029usp.3 uc029usp.4 uc029usp.5 
ENSMUST00000178871.2 Vmn1r257 ENSMUST00000178871.2 vomeronasal 1 receptor 257 (from RefSeq NM_001167154.1) E9PW18 E9PW18_MOUSE ENSMUST00000178871.1 Gm8693 NM_001167154 Vmn1r257 uc012feh.1 uc012feh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012feh.1 uc012feh.2 
ENSMUST00000178879.3 Pfn4 ENSMUST00000178879.3 profilin family, member 4, transcript variant 1 (from RefSeq NM_028376.4) ENSMUST00000178879.1 ENSMUST00000178879.2 NM_028376 PROF4_MOUSE Q6JEK6 Q9D6I3 uc007myh.1 uc007myh.2 uc007myh.3 Involved in male fertility (PubMed:35950913). Required for manchette development and acrosome biogenesis during spermiogenesis (PubMed:35950913). Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Contrary to other profilin family members, does not bind to actin in vitro (By similarity). Cytoplasm Note=In round spermatids, mainly observed in the acroplaxome. During the progression of spermiogenesis, relocalizes to the developing manchette of spermatids step 8 (S8). Coinciding with the initiation of manchette disassembly in spermatids S14, seen in the cytoplasm subjacent to the disassembling manchette. Expressed in testis, in germ cells in seminiferous tubules (at protein level). Homozygous knockout males are infertile, whereas females have normal fertility. Sperm from knockout mice display severe impairment in manchette formation, amorphous sperm head shape and flagellar defects, resulting in reduced sperm motility. Sperm of homozygous knockout males displays a significantly reduced acrosome reaction and decreased viability. Belongs to the profilin family. actin monomer binding cytoplasm cytoskeleton cell cortex lipid binding sequestering of actin monomers uc007myh.1 uc007myh.2 uc007myh.3 
ENSMUST00000178901.8 Zfp872 ENSMUST00000178901.8 zinc finger protein 872 (from RefSeq NM_001033813.4) 9530015I07Rik ENSMUST00000178901.1 ENSMUST00000178901.2 ENSMUST00000178901.3 ENSMUST00000178901.4 ENSMUST00000178901.5 ENSMUST00000178901.6 ENSMUST00000178901.7 NM_001033813 Q3UVL3 Q3UVL3_MOUSE Zfp872 uc009ood.1 uc009ood.2 uc009ood.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc009ood.1 uc009ood.2 uc009ood.3 
ENSMUST00000178904.2 A830019P07Rik ENSMUST00000178904.2 RIKEN cDNA A830019P07 gene (from RefSeq NR_152130.1) ENSMUST00000178904.1 NR_152130 uc008hhc.1 uc008hhc.2 uc008hhc.3 uc008hhc.4 uc008hhc.5 uc008hhc.1 uc008hhc.2 uc008hhc.3 uc008hhc.4 uc008hhc.5 
ENSMUST00000178906.2 ENSMUSG00000121464 ENSMUST00000178906.2 ENSMUSG00000121464 (from geneSymbol) AK029949 ENSMUST00000178906.1 uc008sni.1 uc008sni.2 uc008sni.3 uc008sni.4 uc008sni.5 uc008sni.6 uc008sni.1 uc008sni.2 uc008sni.3 uc008sni.4 uc008sni.5 uc008sni.6 
ENSMUST00000178909.2 Ighd5-8 ENSMUST00000178909.2 Ighd5-8 (from geneSymbol) A0A0G2JDD5 A0A0G2JDD5_MOUSE ENSMUST00000178909.1 Gm37327 Ighd5-7 Ighd5-8 uc288jsl.1 uc288jsl.2 uc288jsl.1 uc288jsl.2 
ENSMUST00000178913.3 Krtap22-2 ENSMUST00000178913.3 keratin associated protein 22-2 (from RefSeq NM_001191018.1) ENSMUST00000178913.1 ENSMUST00000178913.2 J3QNX6 J3QNX6_MOUSE Krtap22-2 NM_001191018 uc012ahx.1 uc012ahx.2 uc012ahx.3 molecular_function cellular_component biological_process uc012ahx.1 uc012ahx.2 uc012ahx.3 
ENSMUST00000178914.3 Gm25816 ENSMUST00000178914.3 Gm25816 (from geneSymbol) ENSMUST00000178914.1 ENSMUST00000178914.2 uc291qum.1 uc291qum.2 uc291qum.1 uc291qum.2 
ENSMUST00000178920.2 Gm21781 ENSMUST00000178920.2 Gm21781 (from geneSymbol) ENSMUST00000178920.1 uc287pgn.1 uc287pgn.2 uc287pgn.1 uc287pgn.2 
ENSMUST00000178922.4 Gm22621 ENSMUST00000178922.4 Gm22621 (from geneSymbol) ENSMUST00000178922.1 ENSMUST00000178922.2 ENSMUST00000178922.3 uc291jll.1 uc291jll.2 uc291jll.1 uc291jll.2 
ENSMUST00000178925.8 Casp8ap2 ENSMUST00000178925.8 caspase 8 associated protein 2, transcript variant 2 (from RefSeq NM_001122978.2) B1AX74 C8AP2_MOUSE Casp8ap2 ENSMUST00000178925.1 ENSMUST00000178925.2 ENSMUST00000178925.3 ENSMUST00000178925.4 ENSMUST00000178925.5 ENSMUST00000178925.6 ENSMUST00000178925.7 Flash NM_001122978 Q9CSW2 Q9WUF3 uc008sew.1 uc008sew.2 uc008sew.3 uc008sew.4 uc008sew.5 Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (By similarity). Required for histone gene transcription and progression through S phase (By similarity). Required for histone gene transcription and S phase progression (By similarity). Involved in TNF- alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa- B. Required for the activation of CASP8 in FAS-mediated apoptosis. Self-associates. Interacts with NPAT (By similarity). Interacts with SRRT (By similarity). Interacts (via SIM domains) with SUMO1 and SUMO2 (By similarity). Interacts with SP100; may negatively regulate CASP8AP2 export from the nucleus to the cytoplasm (By similarity). Interacts with NCOA2 and NCOA3 (By similarity). Component of the death-inducing signaling complex (DISC) with CASP8, FADD and FAS. Interacts with TRAF2. Cytoplasm Nucleus Nucleus, PML body Mitochondrion Note=Exported from the nucleus to the mitochondria upon FAS activation. Highly expressed in heart, brain, thymus, lung, testis and spleen. protease binding transcription corepressor activity protein binding nucleus cytoplasm mitochondrion apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cell cycle extrinsic apoptotic signaling pathway via death domain receptors cysteine-type endopeptidase activator activity involved in apoptotic process PML body SUMO polymer binding Fas signaling pathway identical protein binding apoptotic signaling pathway negative regulation of nucleic acid-templated transcription uc008sew.1 uc008sew.2 uc008sew.3 uc008sew.4 uc008sew.5 
ENSMUST00000178929.3 Esp15 ENSMUST00000178929.3 exocrine gland secreted peptide 15 (from RefSeq NM_001244651.1) A8R0U8 A8R0U8_MOUSE ENSMUST00000178929.1 ENSMUST00000178929.2 Esp15 Gm9041 NM_001244651 uc012atg.1 uc012atg.2 uc012atg.3 uc012atg.4 pheromone activity extracellular space biological_process membrane integral component of membrane uc012atg.1 uc012atg.2 uc012atg.3 uc012atg.4 
ENSMUST00000178930.3 Gm22367 ENSMUST00000178930.3 Gm22367 (from geneSymbol) ENSMUST00000178930.1 ENSMUST00000178930.2 uc291eyf.1 uc291eyf.2 uc291eyf.1 uc291eyf.2 
ENSMUST00000178938.4 Gm20069 ENSMUST00000178938.4 Gm20069 (from geneSymbol) ENSMUST00000178938.1 ENSMUST00000178938.2 ENSMUST00000178938.3 uc288iua.1 uc288iua.2 uc288iua.3 uc288iua.4 uc288iua.1 uc288iua.2 uc288iua.3 uc288iua.4 
ENSMUST00000178942.2 7530416G11Rik ENSMUST00000178942.2 RIKEN cDNA 7530416G11 gene (from RefSeq NM_001256072.1) 7530416G11Rik ENSMUST00000178942.1 J3QJX6 J3QJX6_MOUSE NM_001256072 uc029suf.1 uc029suf.2 molecular_function cellular_component biological_process uc029suf.1 uc029suf.2 
ENSMUST00000178946.9 Kcne3 ENSMUST00000178946.9 potassium voltage-gated channel, Isk-related subfamily, gene 3, transcript variant 6 (from RefSeq NM_001360466.1) ENSMUST00000178946.1 ENSMUST00000178946.2 ENSMUST00000178946.3 ENSMUST00000178946.4 ENSMUST00000178946.5 ENSMUST00000178946.6 ENSMUST00000178946.7 ENSMUST00000178946.8 KCNE3_MOUSE NM_001360466 Q9WTW2 uc009imm.1 uc009imm.2 uc009imm.3 uc009imm.4 Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship. Interacts with KCNB1. Interacts with KCNC2 (By similarity). Associates with KCNC4/Kv3.4 (By similarity). Interacts with KCNQ1; produces a current with nearly instantaneous activation with a linear current-voltage relationship and alters membrane raft localization (By similarity). Cell membrane ingle-pass type I membrane protein Cytoplasm Perikaryon Cell projection, dendrite Membrane raft Note=Colocalizes with KCNB1 at high- density somatodendritic clusters on the surface of hippocampal neurons. Belongs to the potassium channel KCNE family. voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity cytoplasm plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex potassium channel regulator activity membrane integral component of membrane dendrite vesicle neuronal cell body membrane regulation of ion transmembrane transport cell projection perikaryon regulation of potassium ion transport ion channel binding membrane raft regulation of ventricular cardiac muscle cell membrane repolarization potassium ion transmembrane transport ventricular cardiac muscle cell action potential membrane repolarization during action potential regulation of heart rate by cardiac conduction potassium ion export across plasma membrane membrane repolarization during ventricular cardiac muscle cell action potential positive regulation of voltage-gated calcium channel activity negative regulation of delayed rectifier potassium channel activity negative regulation of potassium ion export across plasma membrane negative regulation of voltage-gated potassium channel activity negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential delayed rectifier potassium channel activity voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization uc009imm.1 uc009imm.2 uc009imm.3 uc009imm.4 
ENSMUST00000178950.2 Magea2 ENSMUST00000178950.2 Magea2 (from geneSymbol) BC106842 ENSMUST00000178950.1 Magea2 Q9R2A2 Q9R2A2_MOUSE uc292riz.1 uc292riz.2 molecular_function cellular_component biological_process uc292riz.1 uc292riz.2 
ENSMUST00000178958.3 A630023A22Rik ENSMUST00000178958.3 RIKEN cDNA A630023A22 gene (from RefSeq NM_001251843.1) A630023A22Rik ENSMUST00000178958.1 ENSMUST00000178958.2 J3QP60 J3QP60_MOUSE NM_001251843 uc007tag.1 uc007tag.2 uc007tag.3 uc007tag.4 uc007tag.5 molecular_function cellular_component biological_process uc007tag.1 uc007tag.2 uc007tag.3 uc007tag.4 uc007tag.5 
ENSMUST00000178960.2 Cwc22rt2 ENSMUST00000178960.2 Nucleus speckle (from UniProt A2AK42) A2AK42 A2AK42_MOUSE Cwc22rt1 Cwc22rt2 Cwc22rt4 Cwc22rt5 Cwc22rt6 Cwc22rt7 ENSMUST00000178960.1 uc289xjw.1 uc289xjw.2 Nucleus speckle Belongs to the CWC22 family. mRNA splicing, via spliceosome RNA binding catalytic step 2 spliceosome uc289xjw.1 uc289xjw.2 
ENSMUST00000178962.4 Gm17174 ENSMUST00000178962.4 Gm17174 (from geneSymbol) ENSMUST00000178962.1 ENSMUST00000178962.2 ENSMUST00000178962.3 Gm17174 M0QWQ9 M0QWQ9_MOUSE uc288tpq.1 uc288tpq.2 uc288tpq.1 uc288tpq.2 
ENSMUST00000178979.2 H2al1e ENSMUST00000178979.2 H2A histone family member L1E (from RefSeq NM_001025260.2) ENSMUST00000178979.1 Gm14484 H2al1e NM_001025260 OTTMUSG00000016790 Q810S6 Q810S6_MOUSE uc009sqp.1 uc009sqp.2 The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc009sqp.1 uc009sqp.2 
ENSMUST00000178990.4 Proscos ENSMUST00000178990.4 Proscos (from geneSymbol) AK006309 ENSMUST00000178990.1 ENSMUST00000178990.2 ENSMUST00000178990.3 uc291zbk.1 uc291zbk.2 uc291zbk.3 uc291zbk.4 uc291zbk.1 uc291zbk.2 uc291zbk.3 uc291zbk.4 
ENSMUST00000178997.8 Tpx2 ENSMUST00000178997.8 TPX2, microtubule-associated, transcript variant 5 (from RefSeq NM_001141978.1) A2APB8 ENSMUST00000178997.1 ENSMUST00000178997.2 ENSMUST00000178997.3 ENSMUST00000178997.4 ENSMUST00000178997.5 ENSMUST00000178997.6 ENSMUST00000178997.7 NM_001141978 Q3U500 Q6P9S6 TPX2_MOUSE uc008ngp.1 uc008ngp.2 uc008ngp.3 Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin- alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation. Interacts with AURKA (PubMed:18663142). Interacts with importin-alpha; leading to inactivate TPX2 (By similarity). Interacts with HNRNPU; this interaction recruits HNRNPU to spindle microtubules (MTs) (By similarity). Interacts with BCL2L10 (PubMed:27753540). Interacts with KIF11 (By similarity). Nucleus Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. Expressed during all phases of oocyte maturation; localized at the meiotic spindle and microtubule organizing center during meiosis. Belongs to the TPX2 family. spindle pole protein binding nucleus nucleoplasm cytoplasm microtubule organizing center aster spindle cytoskeleton microtubule apoptotic process cell cycle microtubule cytoskeleton protein kinase binding activation of protein kinase activity axon hillock intercellular bridge spindle assembly cell division regulation of mitotic spindle organization importin-alpha family protein binding mitotic spindle mitotic spindle assembly spindle microtubule uc008ngp.1 uc008ngp.2 uc008ngp.3 
ENSMUST00000178998.3 Cdc5lrt10 ENSMUST00000178998.3 Belongs to the CEF1 family. (from UniProt A0A1W2P7Z8) A0A1W2P7Z8 A0A1W2P7Z8_MOUSE Cdc5lrt10 Cdc5lrt7 ENSMUST00000178998.1 ENSMUST00000178998.2 Gm9045 Gm9049 LF224720 uc029rje.1 uc029rje.2 uc029rje.3 Belongs to the CEF1 family. DNA binding uc029rje.1 uc029rje.2 uc029rje.3 
ENSMUST00000179001.8 Sirpa ENSMUST00000179001.8 signal-regulatory protein alpha, transcript variant 12 (from RefSeq NM_001420768.1) ENSMUST00000179001.1 ENSMUST00000179001.2 ENSMUST00000179001.3 ENSMUST00000179001.4 ENSMUST00000179001.5 ENSMUST00000179001.6 ENSMUST00000179001.7 NM_001420768 Ptpns1 Q6P6I8 Q6P6I8_MOUSE Sirpa uc290akk.1 uc290akk.2 membrane integral component of membrane uc290akk.1 uc290akk.2 
ENSMUST00000179002.8 Unc79 ENSMUST00000179002.8 Unc79 (from geneSymbol) E5CYJ9 E5CYJ9_MOUSE ENSMUST00000179002.1 ENSMUST00000179002.2 ENSMUST00000179002.3 ENSMUST00000179002.4 ENSMUST00000179002.5 ENSMUST00000179002.6 ENSMUST00000179002.7 GQ334471 Unc79 uc011yqs.1 uc011yqs.2 uc011yqs.3 uc011yqs.1 uc011yqs.2 uc011yqs.3 
ENSMUST00000179004.2 H2al1f ENSMUST00000179004.2 H2A histone family member L1F (from RefSeq NM_001242951.1) ENSMUST00000179004.1 H2AL1_MOUSE H2al1a H2al1c H2al1d H2al1f H2al1g H2al1h H2al1i NM_001242951 Q5M8Q2 uc029xif.1 uc029xif.2 uc029xif.3 Atypical histone H2A which can replace conventional H2A in some nucleosomes and may play a role during spermatogenesis. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes, replacing one or more H2A molecules. Interacts with H2BC1/TH2B; preferentially dimerizes with H2BC1/TH2B to form nucleosomes (PubMed:17261847). Nucleus Chromosome Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847). Testis-specific. Strongly enriched in step 12-16 spermatids and accumulate during late spermiogenesis, in condensing spermatids (PubMed:17261847). Remains present in mature spermatozoa isolated from epididymis (PubMed:17261847). Rapidly disappears from the paternal pericentric heterochromatin regions after sperm-egg fusion (PubMed:18703863). In contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding protein binding nucleus chromosome pericentric heterochromatin DNA packaging chromatin organization spermatogenesis cell differentiation DNA packaging complex protein heterodimerization activity uc029xif.1 uc029xif.2 uc029xif.3 
ENSMUST00000179005.3 Mrgpra9 ENSMUST00000179005.3 MAS-related GPR, member A9 (from RefSeq NM_001288801.2) A0A140T8U8 A0A140T8U8_MOUSE ENSMUST00000179005.1 ENSMUST00000179005.2 Mrgpra9 NM_001288801 uc033izp.1 uc033izp.2 uc033izp.3 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc033izp.1 uc033izp.2 uc033izp.3 
ENSMUST00000179021.2 Gm15093 ENSMUST00000179021.2 predicted gene 15093 (from RefSeq NM_001099920.1) A2BI72 A2BI72_MOUSE ENSMUST00000179021.1 Gm15093 NM_001099920 uc057mck.1 uc057mck.2 molecular_function cellular_component biological_process uc057mck.1 uc057mck.2 
ENSMUST00000179030.8 Ankrd44 ENSMUST00000179030.8 ankyrin repeat domain 44 (from RefSeq NM_001081433.3) ANR44_MOUSE B2RXN6 B2RXR6 B7ZWK8 ENSMUST00000179030.1 ENSMUST00000179030.2 ENSMUST00000179030.3 ENSMUST00000179030.4 ENSMUST00000179030.5 ENSMUST00000179030.6 ENSMUST00000179030.7 NM_001081433 uc011wkz.1 uc011wkz.2 Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain- containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1 (By similarity). molecular_function cellular_component biological_process uc011wkz.1 uc011wkz.2 
ENSMUST00000179032.3 Gm6408 ENSMUST00000179032.3 predicted gene 6408 (from RefSeq NM_001243104.1) ENSMUST00000179032.1 ENSMUST00000179032.2 Gm6408 J3QNG1 J3QNG1_MOUSE NM_001243104 uc029vqm.1 uc029vqm.2 uc029vqm.3 guanyl-nucleotide exchange factor activity uc029vqm.1 uc029vqm.2 uc029vqm.3 
ENSMUST00000179061.9 Zfp969 ENSMUST00000179061.9 zinc finger protein 969 (from RefSeq NM_001395020.1) A2ART2 A2ART2_MOUSE ENSMUST00000179061.1 ENSMUST00000179061.2 ENSMUST00000179061.3 ENSMUST00000179061.4 ENSMUST00000179061.5 ENSMUST00000179061.6 ENSMUST00000179061.7 ENSMUST00000179061.8 NM_001395020 Zfp966 Zfp967 Zfp968 Zfp969 uc290dcy.1 uc290dcy.2 uc290dcy.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc290dcy.1 uc290dcy.2 uc290dcy.3 
ENSMUST00000179062.8 Mbtps2 ENSMUST00000179062.8 Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation. (from UniProt Q3TTC2) AK036071 ENSMUST00000179062.1 ENSMUST00000179062.2 ENSMUST00000179062.3 ENSMUST00000179062.4 ENSMUST00000179062.5 ENSMUST00000179062.6 ENSMUST00000179062.7 Q3TTC2 Q8CBG3 TYY2_MOUSE Yy2 uc012hra.1 uc012hra.2 uc012hra.3 uc012hra.4 Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation. Nucleus Weakly expressed by neuronal and glial cells in the cerebral cortex. Expressed by Purkinje cells and in the granular layers of the cerebellum. Expressed in all layers of spermatocytes in testis but not detected in sperm cells. The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene Mbtps2. Belongs to the YY transcription factor family. nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding nucleic acid binding DNA binding nucleus transcription factor complex regulation of transcription from RNA polymerase II promoter PcG protein complex sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc012hra.1 uc012hra.2 uc012hra.3 uc012hra.4 
ENSMUST00000179079.2 Vmn1r107 ENSMUST00000179079.2 vomeronasal 1 receptor 107 (from RefSeq NM_001166759.1) D3YTY1 D3YTY1_MOUSE ENSMUST00000179079.1 NM_001166759 Vmn1r107 Vmn1r130 Vmn1r137 Vmn1r155 Vmn1r165 uc012fcf.1 uc012fcf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fcf.1 uc012fcf.2 
ENSMUST00000179110.3 Gm24701 ENSMUST00000179110.3 Gm24701 (from geneSymbol) ENSMUST00000179110.1 ENSMUST00000179110.2 uc291lxw.1 uc291lxw.2 uc291lxw.1 uc291lxw.2 
ENSMUST00000179116.3 Gm16867 ENSMUST00000179116.3 Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. (from UniProt Q920G8) AK034948 ENSMUST00000179116.1 ENSMUST00000179116.2 MFRN1_MOUSE Mfrn Mscp Q8C367 Q8CEJ7 Q91ZY0 Q920G8 Q9D2G3 Q9D547 Slc25a37 uc029sll.1 uc029sll.2 Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. Reaction=Fe(2+)(in) = Fe(2+)(out); Xref=Rhea:RHEA:28486, ChEBI:CHEBI:29033; Evidence=; Interacts with ACB10; this interaction stabilizes SLC25A37 and enhances the function of SLC25A37 to import mitochondrial iron during erythroid differentiation. Mitochondrion inner membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q920G8-1; Sequence=Displayed; Name=2; IsoId=Q920G8-2; Sequence=VSP_018411, VSP_018412; Name=3; IsoId=Q920G8-3; Sequence=VSP_018405, VSP_018410; Name=4; IsoId=Q920G8-4; Sequence=VSP_018407, VSP_018408; Name=5; IsoId=Q920G8-5; Sequence=VSP_018406, VSP_018409; Highly expressed in hematopoietic organs, fetal liver, bone marrow and spleen. In the developing embryo, it is first detected at 7.5 dpc in the extraembryonic yolk sac, coincident with the appearance of blood islands. Later, restricted expression is seen in 14.5 dpc fetal liver, the primary source of erythrocyte production in mid- gestation. Expression decreases in the spleen around 4-5 weeks of age, suggesting that it is decreased during splenic lymphocyte maturation. Erythroblasts generated from murine embryonic stem cells null for Slc25a37/Mfrn show maturation arrest with severely impaired incorporation of iron into heme. Belongs to the mitochondrial carrier (TC 2.A.29) family. Sequence=BAB29978.1; Type=Erroneous initiation; Evidence=; Sequence=BAB29978.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC25649.1; Type=Frameshift; Evidence=; iron ion transmembrane transporter activity mitochondrion mitochondrial inner membrane ion transport membrane integral component of membrane mitochondrial iron ion transport iron ion homeostasis uc029sll.1 uc029sll.2 
ENSMUST00000179124.2 ENSMUSG00000095787 ENSMUST00000179124.2 ENSMUSG00000095787 (from geneSymbol) ENSMUST00000179124.1 uc289spd.1 uc289spd.2 uc289spd.1 uc289spd.2 
ENSMUST00000179133.2 Gm21863 ENSMUST00000179133.2 Gm21863 (from geneSymbol) ENSMUST00000179133.1 Gm21863 J3KMP8 J3KMP8_MOUSE uc288fgw.1 uc288fgw.2 uc288fgw.1 uc288fgw.2 
ENSMUST00000179135.2 Astx2 ENSMUST00000179135.2 Astx2 (from geneSymbol) DQ874390 ENSMUST00000179135.1 uc292qim.1 uc292qim.2 uc292qim.1 uc292qim.2 
ENSMUST00000179139.3 Ptrhd1 ENSMUST00000179139.3 peptidyl-tRNA hydrolase domain containing 1 (from RefSeq NM_001204912.2) D3Z4S3 ENSMUST00000179139.1 ENSMUST00000179139.2 NM_001204912 PTRD1_MOUSE uc029rqo.1 uc029rqo.2 uc029rqo.3 Reaction=an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L- amino acid + H(+); Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123, Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191; EC=3.1.1.29; Belongs to the PTH2 family. PTRHD1 subfamily. molecular_function aminoacyl-tRNA hydrolase activity biological_process hydrolase activity uc029rqo.1 uc029rqo.2 uc029rqo.3 
ENSMUST00000179140.8 ENSMUSG00000094337 ENSMUST00000179140.8 PRAME family member 8, transcript variant 5 (from RefSeq NM_001418315.1) ENSMUST00000179140.1 ENSMUST00000179140.2 ENSMUST00000179140.3 ENSMUST00000179140.4 ENSMUST00000179140.5 ENSMUST00000179140.6 ENSMUST00000179140.7 NM_001418315 uc291cey.1 uc291cey.2 uc291cey.1 uc291cey.2 
ENSMUST00000179158.2 Gm13289 ENSMUST00000179158.2 predicted gene 13289 (from RefSeq NM_001243165.1) B1AYI0 ENSMUST00000179158.1 Gm13277 Gm13278 Gm13279 Gm13288 Gm13289 Gm13290 NM_001243165 Q8CD73 Q8CD73_MOUSE uc057liw.1 uc057liw.2 uc057liw.3 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc057liw.1 uc057liw.2 uc057liw.3 
ENSMUST00000179160.3 6030469F06Rik ENSMUST00000179160.3 6030469F06Rik (from geneSymbol) AK134407 ENSMUST00000179160.1 ENSMUST00000179160.2 uc288fsx.1 uc288fsx.2 uc288fsx.3 uc288fsx.1 uc288fsx.2 uc288fsx.3 
ENSMUST00000179162.7 Fer1l5 ENSMUST00000179162.7 fer-1 like family member 5 (from RefSeq NM_001277076.2) ENSMUST00000179162.1 ENSMUST00000179162.2 ENSMUST00000179162.3 ENSMUST00000179162.4 ENSMUST00000179162.5 ENSMUST00000179162.6 FR1L5_MOUSE M1J7P7 NM_001277076 P0DM40 uc033fip.1 uc033fip.2 uc033fip.3 Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts (via second C2 domain) with EHD1 and EHD2. Cell membrane Membrane ; Single-pass membrane protein Note=Colocalizes with EHD1 and EHD2 at the plasma membrane in myoblasts and myotubes. Localizes into foci at the plasma membrane. Expressed in differentiating myoblasts and myotubes. Up-regulated during myotube formation. Belongs to the ferlin family. molecular_function cellular_component plasma membrane myoblast fusion biological_process membrane integral component of membrane uc033fip.1 uc033fip.2 uc033fip.3 
ENSMUST00000179163.3 Mlst8 ENSMUST00000179163.3 MTOR associated protein, LST8 homolog (S. cerevisiae), transcript variant 3 (from RefSeq NM_001252464.1) ENSMUST00000179163.1 ENSMUST00000179163.2 Gbl LST8_MOUSE Lst8 Mlst8 NM_001252464 Q8BNG8 Q8C882 Q9DCJ1 Q9JKK6 uc008awj.1 uc008awj.2 uc008awj.3 uc008awj.4 uc008awj.5 Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals (PubMed:17141160). mTORC1 is activated in response to growth factors or amino acids (By similarity). In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (By similarity). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (By similarity). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (By similarity). Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity (By similarity). In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR- mediated inhibition of MTOR activity (By similarity). mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive (By similarity). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (By similarity). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (By similarity). mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation (By similarity). mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422' (By similarity). mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657' (By similarity). Part of the mechanistic target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8 and RPTOR. mTORC1 associates with AKT1S1/PRAS40, which inhibits its activity. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Within mTORC1, interacts directly with MTOR and RPTOR. Part of the mechanistic target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. mTORC1 and mTORC2 associate with DEPTOR, which regulates its activity. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3. Interacts with SLC38A7; this interaction promotes the recruitment of mTORC1 to the lysosome and its subsequent activation. Lysosome membrane Cytoplasm Note=Targeting to lysosomal membrane depends on amino acid availability: mTORC1 is recruited to lysosome membranes via interaction with GTP-bound form of RagA/RRAGA (or RagB/RRAGB) in complex with the GDP-bound form of RagC/RRAGC (or RagD/RRAGD), promoting its mTORC1 recruitment to the lysosomes. Phosphorylation at Thr-51 by CDK1 promotes ubiquitination by the SCF(FBXW7) complex, followed by degradation. Ubiquitination by the SCF(FBXW7) and SCF(FBXW11) complexes following phosphorylation at Thr-51 by CDK1, leads to its degradation by the proteasome. Death around 10.5 dpc due to multiple defects in vascular system development. In addition, they exhibit a delayed development of their cephalic region. Belongs to the WD repeat LST8 family. cytoplasm cytosol positive regulation of actin filament polymerization TOR signaling TORC1 complex TORC2 complex positive regulation of TOR signaling regulation of actin cytoskeleton organization TORC1 signaling regulation of GTPase activity protein serine/threonine kinase activator activity positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein serine/threonine kinase activity uc008awj.1 uc008awj.2 uc008awj.3 uc008awj.4 uc008awj.5 
ENSMUST00000179165.9 Fzd6 ENSMUST00000179165.9 frizzled class receptor 6, transcript variant 4 (from RefSeq NM_001411227.1) ENSMUST00000179165.1 ENSMUST00000179165.2 ENSMUST00000179165.3 ENSMUST00000179165.4 ENSMUST00000179165.5 ENSMUST00000179165.6 ENSMUST00000179165.7 ENSMUST00000179165.8 FZD6_MOUSE NM_001411227 Q61089 uc007vnz.1 uc007vnz.2 uc007vnz.3 uc007vnz.4 uc007vnz.5 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity). Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Interacts with LMBR1L. Membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Cell surface Apical cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Colocalizes with FZD3 at the apical face of cells (PubMed:16495441). Localizes to the endoplasmic reticulum membrane in the presence of LMBR1L (PubMed:31073040). Expressed in both hair cells and supporting cells in the utricle, saccule, cristae and the organ of Corti in the inner ear (at protein level). Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. The FZ domain is involved in binding with Wnt ligands. Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. Half of the males without the gene, but not females, display abnormal claw morphology or absent claws compared to wild-type; at the age of 2 to 3 months, the claws disappear or become rudimentary on the hind limbs (PubMed:21665003). FZD3 and FZD6 double knockout embryos have a curled tail, exhibit defects in neural tube and eyelids closure, in the orientation of hair bundles on inner-ear sensory cells and die at birth (PubMed:16495441). Belongs to the G-protein coupled receptor Fz/Smo family. establishment of planar polarity neural tube closure hair follicle development transmembrane signaling receptor activity G-protein coupled receptor activity protein binding plasma membrane signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway multicellular organism development nervous system development cell surface membrane integral component of membrane Wnt signaling pathway apical plasma membrane apicolateral plasma membrane Wnt-protein binding platelet activation cytoplasmic vesicle membrane midbrain development cytoplasmic vesicle ubiquitin protein ligase binding cell proliferation in midbrain non-canonical Wnt signaling pathway embryonic nail plate morphogenesis inner ear morphogenesis Wnt-activated receptor activity negative regulation of sequence-specific DNA binding transcription factor activity apical part of cell establishment of body hair planar orientation canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway negative regulation of canonical Wnt signaling pathway uc007vnz.1 uc007vnz.2 uc007vnz.3 uc007vnz.4 uc007vnz.5 
ENSMUST00000179166.2 Ighd5-2 ENSMUST00000179166.2 Ighd5-2 (from geneSymbol) ENSMUST00000179166.1 uc288jss.1 uc288jss.2 uc288jss.1 uc288jss.2 
ENSMUST00000179181.3 Trgc4 ENSMUST00000179181.3 Trgc4 (from geneSymbol) A0A075B6C7 A0A075B6C7_MOUSE AK088999 ENSMUST00000179181.1 ENSMUST00000179181.2 Tcrg-C4 Trgc4 uc288lcc.1 uc288lcc.2 membrane integral component of membrane uc288lcc.1 uc288lcc.2 
ENSMUST00000179192.2 Cwc22rt1 ENSMUST00000179192.2 Nucleus speckle (from UniProt A2AK42) A2AK42 A2AK42_MOUSE Cwc22rt1 Cwc22rt2 Cwc22rt4 Cwc22rt5 Cwc22rt6 Cwc22rt7 ENSMUST00000179192.1 uc289xju.1 uc289xju.2 Nucleus speckle Belongs to the CWC22 family. mRNA splicing, via spliceosome RNA binding catalytic step 2 spliceosome uc289xju.1 uc289xju.2 
ENSMUST00000179196.3 Tspan8 ENSMUST00000179196.3 tetraspanin 8, transcript variant 1 (from RefSeq NM_146010.2) ENSMUST00000179196.1 ENSMUST00000179196.2 NM_146010 Q8R3G9 TSN8_MOUSE uc007hbn.1 uc007hbn.2 uc007hbn.3 uc007hbn.4 Membrane ; Multi-pass membrane protein Belongs to the tetraspanin (TM4SF) family. molecular_function integrin binding integral component of plasma membrane spermatogenesis cell surface regulation of gene expression membrane integral component of membrane negative regulation of blood coagulation uc007hbn.1 uc007hbn.2 uc007hbn.3 uc007hbn.4 
ENSMUST00000179200.2 Ear1 ENSMUST00000179200.2 Belongs to the pancreatic ribonuclease family. (from UniProt Q53ZF0) BC117060 ENSMUST00000179200.1 Ear1 Q53ZF0 Q53ZF0_MOUSE Raf1 uc033gpk.1 uc033gpk.2 uc033gpk.3 Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity hydrolase activity nucleic acid phosphodiester bond hydrolysis uc033gpk.1 uc033gpk.2 uc033gpk.3 
ENSMUST00000179205.2 Foxl3 ENSMUST00000179205.2 forkhead box L3 (from RefSeq NM_001195128.1) ENSMUST00000179205.1 Foxl3 Gm5294 J3QP53 J3QP53_MOUSE NM_001195128 uc012efo.1 uc012efo.2 Nucleus RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter anatomical structure morphogenesis cell differentiation sequence-specific DNA binding uc012efo.1 uc012efo.2 
ENSMUST00000179206.2 Vmn1r138 ENSMUST00000179206.2 vomeronasal 1 receptor 138 (from RefSeq NM_001167169.1) D3YTY2 D3YTY2_MOUSE ENSMUST00000179206.1 NM_001167169 Vmn1r111 Vmn1r131 Vmn1r138 Vmn1r166 uc012fdo.1 uc012fdo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fdo.1 uc012fdo.2 
ENSMUST00000179209.8 Dcdc2b ENSMUST00000179209.8 doublecortin domain containing 2b (from RefSeq NM_001195730.2) Dcdc2b ENSMUST00000179209.1 ENSMUST00000179209.2 ENSMUST00000179209.3 ENSMUST00000179209.4 ENSMUST00000179209.5 ENSMUST00000179209.6 ENSMUST00000179209.7 J3KML0 J3KML0_MOUSE NM_001195730 uc012dlr.1 uc012dlr.2 This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Oct 2011]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN01164132 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## molecular_function microtubule organizing center microtubule biological_process intracellular signal transduction cortical actin cytoskeleton uc012dlr.1 uc012dlr.2 
ENSMUST00000179211.2 ENSMUSG00000095250 ENSMUST00000179211.2 ENSMUSG00000095250 (from geneSymbol) ENSMUST00000179211.1 uc289spc.1 uc289spc.2 uc289spc.1 uc289spc.2 
ENSMUST00000179218.9 Golga5 ENSMUST00000179218.9 golgin A5, transcript variant 1 (from RefSeq NM_001199004.1) ENSMUST00000179218.1 ENSMUST00000179218.2 ENSMUST00000179218.3 ENSMUST00000179218.4 ENSMUST00000179218.5 ENSMUST00000179218.6 ENSMUST00000179218.7 ENSMUST00000179218.8 GOGA5_MOUSE NM_001199004 O88317 Q3TGE7 Q3U6S5 Q3UUF9 Q9QYE6 Retii uc007oug.1 uc007oug.2 uc007oug.3 uc007oug.4 Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport (By similarity). Homodimer. Interacts with RAB1A that has been activated by GTP-binding. Interacts with isoform CASP of CUX1 (By similarity). Q9QYE6; Q99N72: Mcf2; NbExp=3; IntAct=EBI-644242, EBI-641874; Golgi apparatus membrane ; Single- pass type IV membrane protein Note=Found throughout the Golgi. Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase (By similarity). Golgi cis cisterna Golgi trans cisterna Golgi membrane retrograde transport, vesicle recycling within Golgi protein binding Golgi apparatus Golgi medial cisterna cis-Golgi network Golgi organization membrane integral component of membrane Rab GTPase binding COPI-coated vesicle membrane protein binding, bridging Golgi cisterna protein homodimerization activity Golgi vesicle transport uc007oug.1 uc007oug.2 uc007oug.3 uc007oug.4 
ENSMUST00000179234.2 Aldoart1 ENSMUST00000179234.2 Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3- phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729, ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=4.1.2.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14730; Evidence=; (from UniProt Q9CPQ9) AK014956 Aldoart1 ENSMUST00000179234.1 Q9CPQ9 Q9CPQ9_MOUSE uc290nhf.1 uc290nhf.2 Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3- phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729, ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=4.1.2.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14730; Evidence=; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 4/4. Cytoplasm, myofibril, sarcomere, I band Cytoplasm, myofibril, sarcomere, M line Belongs to the class I fructose-bisphosphate aldolase family. catalytic activity fructose-bisphosphate aldolase activity cytosol glycolytic process lyase activity fructose 1,6-bisphosphate metabolic process sperm fibrous sheath uc290nhf.1 uc290nhf.2 
ENSMUST00000179236.2 Gm26138 ENSMUST00000179236.2 Gm26138 (from geneSymbol) DQ558729 ENSMUST00000179236.1 uc290mxn.1 uc290mxn.2 uc290mxn.1 uc290mxn.2 
ENSMUST00000179243.3 Rlbp1 ENSMUST00000179243.3 retinaldehyde binding protein 1, transcript variant 3 (from RefSeq NM_001357450.1) Cralbp ENSMUST00000179243.1 ENSMUST00000179243.2 NM_001357450 Q9Z275 RLBP1_MOUSE Rlbp1 uc009hyf.1 uc009hyf.2 uc009hyf.3 uc009hyf.4 Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11- trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. Interacts with DEGS1; the interaction increases synthesis of chromophore-precursors by DEGS1. Cytoplasm. Retina and pineal gland. Expressed in Mueller cells (at protein level) (PubMed:23143414). 11-cis retinal binding cytoplasm visual perception retinal binding retinol binding cell body response to stimulus uc009hyf.1 uc009hyf.2 uc009hyf.3 uc009hyf.4 
ENSMUST00000179248.2 Scgb2b20 ENSMUST00000179248.2 secretoglobin, family 2B, member 20 (from RefSeq NM_001009952.2) Abpbg20 ENSMUST00000179248.1 J3QK77 J3QK77_MOUSE NM_001009952 Scgb2b20 uc009gik.1 uc009gik.2 uc009gik.3 Secreted Belongs to the secretoglobin family. extracellular space uc009gik.1 uc009gik.2 uc009gik.3 
ENSMUST00000179257.2 Gm21846 ENSMUST00000179257.2 Gm21846 (from geneSymbol) ENSMUST00000179257.1 uc290tna.1 uc290tna.2 uc290tna.1 uc290tna.2 
ENSMUST00000179262.2 Ighd5-3 ENSMUST00000179262.2 Ighd5-3 (from geneSymbol) ENSMUST00000179262.1 uc288jsp.1 uc288jsp.2 uc288jsp.1 uc288jsp.2 
ENSMUST00000179267.4 Trav14-2 ENSMUST00000179267.4 Trav14-2 (from geneSymbol) A0A075B694 A0A075B694_MOUSE ENSMUST00000179267.1 ENSMUST00000179267.2 ENSMUST00000179267.3 Trav14-2 U83242 uc288uaq.1 uc288uaq.2 uc288uaq.1 uc288uaq.2 
ENSMUST00000179269.3 Shisa8 ENSMUST00000179269.3 shisa family member 8, transcript variant 5 (from RefSeq NR_183233.1) ENSMUST00000179269.1 ENSMUST00000179269.2 J3QNX5 NR_183233 SHSA8_MOUSE Shisa8 uc029sua.1 uc029sua.2 uc029sua.3 May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses. Interacts with AMPAR subunits GRIA1 and GRIA2. Membrane ; Single-pass type I membrane protein Brain-specific. Highly expressed in cerebellum and olfactory bulb. Undetectable in the brain of 17 dpc embryos. Expressed in olfactory bulb from postnatal day 1 (P1) and then in cerebellum from postnatal day 14 (P14). Belongs to the shisa family. molecular_function postsynaptic density membrane integral component of membrane AMPA glutamate receptor complex dendritic spine membrane synapse postsynaptic membrane regulation of short-term neuronal synaptic plasticity regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity uc029sua.1 uc029sua.2 uc029sua.3 
ENSMUST00000179279.2 Rfpl4b ENSMUST00000179279.2 ret finger protein-like 4B (from RefSeq NM_001177783.1) ENSMUST00000179279.1 J3QPR6 J3QPR6_MOUSE NM_001177783 Rfpl4b uc011xct.1 uc011xct.2 molecular_function cellular_component biological_process uc011xct.1 uc011xct.2 
ENSMUST00000179285.3 H4c16 ENSMUST00000179285.3 H4 histone 16 (from RefSeq NM_175652.3) A0AUM5 A4FUP8 A4QMY0 ENSMUST00000179285.1 ENSMUST00000179285.2 H4-12 H4-53 H4_MOUSE H4c1 H4c11 H4c12 H4c14 H4c2 H4c3 H4c4 H4c6 H4c8 H4c9 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist1h4m Hist2h4 Hist2h4a Hist4h4 NM_175652 P02304 P02305 P62806 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 uc009emd.1 uc009emd.2 uc009emd.3 uc009emd.4 uc009emd.5 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3- H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). P62806; Q8CDM1: Atad2; NbExp=2; IntAct=EBI-299632, EBI-2944582; P62806; Q9EQQ9: Oga; NbExp=2; IntAct=EBI-299632, EBI-8321615; Nucleus Chromosome Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Sumoylated, which is associated with transcriptional repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H4 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly DNA-templated transcription, initiation protein domain specific binding macromolecular complex negative regulation of megakaryocyte differentiation protein heterodimerization activity protein heterotetramerization uc009emd.1 uc009emd.2 uc009emd.3 uc009emd.4 uc009emd.5 
ENSMUST00000179292.2 ENSMUSG00000095450 ENSMUST00000179292.2 ENSMUSG00000095450 (from geneSymbol) ENSMUST00000179292.1 uc289spl.1 uc289spl.2 uc289spl.1 uc289spl.2 
ENSMUST00000179306.2 Gm28051 ENSMUST00000179306.2 Gm28051 (from geneSymbol) AK018995 ENSMUST00000179306.1 Gm28051 J3QMA2 J3QMA2_MOUSE uc288iud.1 uc288iud.2 EKC/KEOPS complex uc288iud.1 uc288iud.2 
ENSMUST00000179308.3 Edaradd ENSMUST00000179308.3 EDAR associated via death domain (from RefSeq NM_133643.4) ENSMUST00000179308.1 ENSMUST00000179308.2 Edaradd NM_133643 Q5D0F1 Q5D0F1_MOUSE uc007plp.1 uc007plp.2 uc007plp.3 uc007plp.4 signal transduction uc007plp.1 uc007plp.2 uc007plp.3 uc007plp.4 
ENSMUST00000179314.3 Amy2a3 ENSMUST00000179314.3 amylase 2a1 (from RefSeq NM_001411494.1) AM2A5_MOUSE Amy2 Amy2a Amy2a5 ENSMUST00000179314.1 ENSMUST00000179314.2 NM_001411494 P00688 Q4VBW6 Q61295 Q61296 Q64301 uc008ray.1 uc008ray.2 uc008ray.3 uc008ray.4 Reaction=Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D- glucose units.; EC=3.2.1.1; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence=; Note=Binds 1 Cl(-) ion per subunit. ; Monomer. Secreted, extracellular space. Belongs to the glycosyl hydrolase 13 family. catalytic activity alpha-amylase activity calcium ion binding extracellular region extracellular space carbohydrate metabolic process metabolic process carbohydrate catabolic process amylase activity hydrolase activity hydrolase activity, acting on glycosyl bonds chloride ion binding cation binding metal ion binding uc008ray.1 uc008ray.2 uc008ray.3 uc008ray.4 
ENSMUST00000179322.2 Evi2b ENSMUST00000179322.2 ecotropic viral integration site 2 (from RefSeq NM_146023.4) ENSMUST00000179322.1 EVI2B_MOUSE Evi2b NM_146023 Q3U1A3 Q8VD58 uc007kko.1 uc007kko.2 uc007kko.3 This locus represents naturally occurring readthrough transcription between the neighboring Evi2a (ecotropic viral integration site 2a) and Evi2b (ecotropic viral integration site 2b) genes on chromosome 11. The readthrough transcript encodes a protein identical to that of the downstream gene product. [provided by RefSeq, May 2013]. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164140 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 14017, 216984 ##RefSeq-Attributes-END## Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. Membrane ; Single-pass type I membrane protein Expressed in myeloid and lymphoid progenitors and increased in mature hematopoietic populations with the highest levels in granulocytes. molecular_function membrane integral component of membrane positive regulation of granulocyte differentiation negative regulation of apoptotic process positive regulation of neutrophil differentiation myeloid cell development negative regulation of cell cycle arrest regulation of stem cell division uc007kko.1 uc007kko.2 uc007kko.3 
ENSMUST00000179325.2 Btbd35f20 ENSMUST00000179325.2 BTB domain containing 35, family member 20 (from RefSeq NM_001085553.1) A2CG71 A2CG71_MOUSE Btbd35f19 Btbd35f20 ENSMUST00000179325.1 NM_001085553 uc029xhp.1 uc029xhp.2 molecular_function cellular_component biological_process uc029xhp.1 uc029xhp.2 
ENSMUST00000179333.3 Ppp1r2-ps6 ENSMUST00000179333.3 Ppp1r2-ps6 (from geneSymbol) ENSMUST00000179333.1 ENSMUST00000179333.2 uc289gsy.1 uc289gsy.2 uc289gsy.3 uc289gsy.1 uc289gsy.2 uc289gsy.3 
ENSMUST00000179334.3 Gm22108 ENSMUST00000179334.3 Gm22108 (from geneSymbol) ENSMUST00000179334.1 ENSMUST00000179334.2 uc288qgf.1 uc288qgf.2 uc288qgf.1 uc288qgf.2 
ENSMUST00000179343.3 Purb ENSMUST00000179343.3 purine rich element binding protein B (from RefSeq NM_011221.3) ENSMUST00000179343.1 ENSMUST00000179343.2 NM_011221 O35295 PURB_MOUSE uc007hyr.1 uc007hyr.2 uc007hyr.3 uc007hyr.4 uc007hyr.5 Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Homodimer, heterodimer with PURA and heterotrimer with PURA and YBX1/Y-box protein 1. Nucleus. Belongs to the PUR DNA-binding protein family. negative regulation of transcription from RNA polymerase II promoter translation repressor activity, nucleic acid binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding double-stranded telomeric DNA binding single-stranded DNA binding transcription factor activity, sequence-specific DNA binding RNA binding mRNA binding protein binding nucleus DNA replication factor A complex DNA unwinding involved in DNA replication apoptotic process transcription factor binding cell proliferation negative regulation of translation cell differentiation purine-rich negative regulatory element binding sequence-specific DNA binding negative regulation of transcription, DNA-templated SMAD binding uc007hyr.1 uc007hyr.2 uc007hyr.3 uc007hyr.4 uc007hyr.5 
ENSMUST00000179348.8 Ott ENSMUST00000179348.8 Ott (from geneSymbol) ENSMUST00000179348.1 ENSMUST00000179348.2 ENSMUST00000179348.3 ENSMUST00000179348.4 ENSMUST00000179348.5 ENSMUST00000179348.6 ENSMUST00000179348.7 Gm15085 Ott Q62012 Q62012_MOUSE X96606 uc292ray.1 uc292ray.2 molecular_function cellular_component biological_process uc292ray.1 uc292ray.2 
ENSMUST00000179359.2 Astx4b ENSMUST00000179359.2 Astx4b (from geneSymbol) DQ874390 ENSMUST00000179359.1 uc292qjg.1 uc292qjg.2 uc292qjg.1 uc292qjg.2 
ENSMUST00000179360.3 Gm38393 ENSMUST00000179360.3 Nucleus (from UniProt Q9WU12) AK144386 ENSMUST00000179360.1 ENSMUST00000179360.2 Q924D8 Q9WU12 SNURF_MOUSE Snurf uc291qvr.1 uc291qvr.2 Nucleus Expressed in brain and embryonic stem (ES) cells (at protein level). Expressed in the brain, ovary, testis, liver, heart, kidney and muscle. Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF. Only the primary 1.6-kb bicistronic SNURF- SNRPN transcript is detected. Belongs to the SNURF family. nucleus nuclear speck ATPase binding uc291qvr.1 uc291qvr.2 
ENSMUST00000179364.3 Smim18 ENSMUST00000179364.3 small integral membrane protein 18 (from RefSeq NM_001206849.2) 2700090O03Rik ENSMUST00000179364.1 ENSMUST00000179364.2 J3QNP2 J3QNP2_MOUSE NM_001206849 Smim18 uc009lkj.1 uc009lkj.2 uc009lkj.3 Membrane ; Single- pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc009lkj.1 uc009lkj.2 uc009lkj.3 
ENSMUST00000179369.2 Samt1b ENSMUST00000179369.2 Samt1b (from geneSymbol) 4921511M17Rik A2BED8 A2BED8_MOUSE AK019538 ENSMUST00000179369.1 Gm10057 Gm5645 Samt1 Samt1b Samt1c uc292rij.1 uc292rij.2 molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc292rij.1 uc292rij.2 
ENSMUST00000179372.3 Gm13276 ENSMUST00000179372.3 predicted gene 13276 (from RefSeq NM_001085532.3) A0A087WR18 A0A087WR18_MOUSE ENSMUST00000179372.1 ENSMUST00000179372.2 Gm13276 If1ha5 NM_001085532 uc008tnq.1 uc008tnq.2 uc008tnq.3 uc008tnq.4 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tnq.1 uc008tnq.2 uc008tnq.3 uc008tnq.4 
ENSMUST00000179384.3 Smbd1 ENSMUST00000179384.3 somatomedin B domain containing 1 (from RefSeq NM_001256309.1) ENSMUST00000179384.1 ENSMUST00000179384.2 Gm933 J3QPC1 J3QPC1_MOUSE NM_001256309 Smbd1 uc029swv.1 uc029swv.2 uc029swv.3 molecular_function scavenger receptor activity cellular_component endocytosis immune response biological_process polysaccharide binding uc029swv.1 uc029swv.2 uc029swv.3 
ENSMUST00000179386.2 Or6k8-ps1 ENSMUST00000179386.2 olfactory receptor 421, pseudogene 1, transcript variant 1, non-coding (from RefSeq NR_047667.1) ENSMUST00000179386.1 NR_047667 uc011wwy.1 uc011wwy.2 uc011wwy.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene appears to represent a strain-specific polymorphic pseudogene in mouse, where some strains, including the C57BL/6 reference genome strain, have a non-functional allele, while other strains have a protein-coding allele. [provided by RefSeq, Apr 2012]. uc011wwy.1 uc011wwy.2 uc011wwy.3 
ENSMUST00000179390.2 Vmn1r131 ENSMUST00000179390.2 vomeronasal 1 receptor 131 (from RefSeq NM_001166839.1) D3YTY2 D3YTY2_MOUSE ENSMUST00000179390.1 NM_001166839 Vmn1r111 Vmn1r131 Vmn1r138 Vmn1r166 uc012fdg.1 uc012fdg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fdg.1 uc012fdg.2 
ENSMUST00000179391.8 Actmap ENSMUST00000179391.8 actin maturation protease, transcript variant 1 (from RefSeq NM_001243888.1) ACTMP_MOUSE Actmap D3Z7G4 ENSMUST00000179391.1 ENSMUST00000179391.2 ENSMUST00000179391.3 ENSMUST00000179391.4 ENSMUST00000179391.5 ENSMUST00000179391.6 ENSMUST00000179391.7 J3QPC3 NM_001243888 uc029wea.1 uc029wea.2 Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (PubMed:36173861). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins Actb and Actg1 after translation (PubMed:36173861). Cleaves N-terminal acetylated cysteine of muscle alpha-actins Acta1, Actc1 and Acta2 after canonical removal of N-terminal methionine (PubMed:36173861). [Actin maturation protease]: Reaction=H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl- [protein] = N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl- [protein]; Xref=Rhea:RHEA:74571, Rhea:RHEA-COMP:12669, Rhea:RHEA- COMP:12693, ChEBI:CHEBI:15377, ChEBI:CHEBI:64720, ChEBI:CHEBI:71670, ChEBI:CHEBI:133063; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74572; Evidence=; [Actin maturation protease]: Reaction=H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl- [protein] = N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl- [protein]; Xref=Rhea:RHEA:74575, Rhea:RHEA-COMP:12668, Rhea:RHEA- COMP:12697, ChEBI:CHEBI:15377, ChEBI:CHEBI:64721, ChEBI:CHEBI:71670, ChEBI:CHEBI:133360; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74576; Evidence=; [Actin maturation protease]: Reaction=H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl- [protein] = N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein]; Xref=Rhea:RHEA:74579, Rhea:RHEA-COMP:12669, Rhea:RHEA-COMP:18395, ChEBI:CHEBI:15377, ChEBI:CHEBI:64720, ChEBI:CHEBI:78236, ChEBI:CHEBI:193599; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74580; Evidence=; [Actin maturation protease]: Reaction=H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl- [protein] = N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein]; Xref=Rhea:RHEA:74583, Rhea:RHEA-COMP:12668, Rhea:RHEA-COMP:18396, ChEBI:CHEBI:15377, ChEBI:CHEBI:64721, ChEBI:CHEBI:78236, ChEBI:CHEBI:193601; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74584; Evidence=; Interacts (via N-terminus) with PFN2 isoforms 1/IIa and 2/IIb; the interactions may facilitate efficient cleavage of the acetylated N- terminus of immature actin (By similarity). Interacts with PFN1 (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=J3QPC3-1; Sequence=Displayed; Name=2; IsoId=J3QPC3-2; Sequence=VSP_061770, VSP_061771; The N-terminal proline-rich disordered region contributes to the interaction with PFN2. Animals are alive, but suffer from muscle weakness (PubMed:36173861). Absence of cytoplasmic actin processing in intestine and kidney (PubMed:36173861). Accumulation of immature alpha- skeletal muscle (Acta1), alpha-cardiac muscle (Actc1), and alpha-smooth muscle (Actc2) actin with N-terminal acetylated cysteine (PubMed:36173861). Undetectable actin maturation and accumulation of immature actin in acetylated and methionated state in intestine and kidney, however no effect on the total levels of actin (PubMed:36173861). Shorter sarcomeric thin filaments in skeletal muscle, decrease in muscle function and progressive accumulation of centralized nuclei, a common hallmark of myopathies (PubMed:36173861). Belongs to the ACTMAP family. molecular_function cellular_component biological_process uc029wea.1 uc029wea.2 
ENSMUST00000179396.3 Gm23793 ENSMUST00000179396.3 Gm23793 (from geneSymbol) ENSMUST00000179396.1 ENSMUST00000179396.2 uc287wbg.1 uc287wbg.2 uc287wbg.1 uc287wbg.2 
ENSMUST00000179399.4 A630076J17Rik ENSMUST00000179399.4 A630076J17Rik (from geneSymbol) AK080367 ENSMUST00000179399.1 ENSMUST00000179399.2 ENSMUST00000179399.3 uc029uoc.1 uc029uoc.2 uc029uoc.3 uc029uoc.4 uc029uoc.1 uc029uoc.2 uc029uoc.3 uc029uoc.4 
ENSMUST00000179404.8 Rbmyf2 ENSMUST00000179404.8 Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. (from UniProt B2RWR6) B2RWR6 B2RWR6_MOUSE BC150670 ENSMUST00000179404.1 ENSMUST00000179404.2 ENSMUST00000179404.3 ENSMUST00000179404.4 ENSMUST00000179404.5 ENSMUST00000179404.6 ENSMUST00000179404.7 Rbmy1a1 Rbmyf2 Rbmyf3 uc292rxr.1 uc292rxr.2 Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. molecular_function nucleic acid binding RNA binding cellular_component nucleus spliceosomal complex biological_process positive regulation of mRNA splicing, via spliceosome ribonucleoprotein complex uc292rxr.1 uc292rxr.2 
ENSMUST00000179408.3 Rbm31y ENSMUST00000179408.3 RNA binding motif 31, Y-linked (from RefSeq NM_028970.1) ENSMUST00000179408.1 ENSMUST00000179408.2 Gm21379 NM_028970 Q9D3U4 Q9D3U4_MOUSE Rbm31y uc029xsd.1 uc029xsd.2 uc029xsd.3 Nucleus nucleic acid binding RNA binding ribonucleoprotein complex uc029xsd.1 uc029xsd.2 uc029xsd.3 
ENSMUST00000179412.2 Muc3a ENSMUST00000179412.2 Muc3a (from geneSymbol) A630081J09Rik AK153770 ENSMUST00000179412.1 Muc3a Q3U5A2 Q3U5A2_MOUSE uc029vpk.1 uc029vpk.2 uc029vpk.3 molecular_function cellular_component biological_process membrane integral component of membrane uc029vpk.1 uc029vpk.2 uc029vpk.3 
ENSMUST00000179425.2 Gm13272 ENSMUST00000179425.2 predicted gene 13272 (from RefSeq NM_001161608.1) B1AYI3 B1AYI3_MOUSE ENSMUST00000179425.1 Gm13272 Gm13285 Gm13287 If1ha7 NM_001161608 uc057lix.1 uc057lix.2 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc057lix.1 uc057lix.2 
ENSMUST00000179433.8 Aldh3b3 ENSMUST00000179433.8 aldehyde dehydrogenase 3 family, member B3 (from RefSeq NM_028545.2) AL3B3_MOUSE Aldh3b3 ENSMUST00000179433.1 ENSMUST00000179433.2 ENSMUST00000179433.3 ENSMUST00000179433.4 ENSMUST00000179433.5 ENSMUST00000179433.6 ENSMUST00000179433.7 J3QMK6 NM_028545 Q9D9K6 uc029tql.1 uc029tql.2 uc029tql.3 Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence=; Reaction=2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+); Xref=Rhea:RHEA:33739, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17600, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Reaction=H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate; Xref=Rhea:RHEA:44100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:25646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; Cell membrane ; Lipid-anchor Expressed in testis, kidney, small intestine, spleen, white adipose tissue, liver and lung. Geranylgeranylation is important for membrane localization and enzyme activity. Belongs to the aldehyde dehydrogenase family. Sequence=BAB24748.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; 3-chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity cytoplasm plasma membrane cellular aldehyde metabolic process membrane oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity oxidation-reduction process uc029tql.1 uc029tql.2 uc029tql.3 
ENSMUST00000179434.8 Cyp4f14 ENSMUST00000179434.8 cytochrome P450, family 4, subfamily f, polypeptide 14, transcript variant 6 (from RefSeq NM_001357788.1) CP4FE_MOUSE ENSMUST00000179434.1 ENSMUST00000179434.2 ENSMUST00000179434.3 ENSMUST00000179434.4 ENSMUST00000179434.5 ENSMUST00000179434.6 ENSMUST00000179434.7 NM_001357788 Q52L93 Q9EP75 uc029tgt.1 uc029tgt.2 uc029tgt.3 Cytochromes P450 are a group of heme-thiolate monooxygenases. Catalyzes the omega-hydroxylation of LTB4 (By similarity). Reaction=leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:22176, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57460, ChEBI:CHEBI:57461, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.94; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Lipid metabolism; leukotriene B4 degradation. Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane icosanoid metabolic process arachidonic acid monooxygenase activity membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen arachidonic acid metabolic process heme binding organelle membrane intracellular membrane-bounded organelle metal ion binding leukotriene-B4 20-monooxygenase activity arachidonic acid binding oxidation-reduction process uc029tgt.1 uc029tgt.2 uc029tgt.3 
ENSMUST00000179443.3 Gfy ENSMUST00000179443.3 golgi-associated olfactory signaling regulator (from RefSeq NM_001195255.1) ENSMUST00000179443.1 ENSMUST00000179443.2 GFY_MOUSE Gm581 Goofy J3KML8 NM_001195255 uc012fkd.1 uc012fkd.2 uc012fkd.3 Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling. Golgi apparatus membrane ; Single-pass type I membrane protein Specifically expressed in the olfactory epithelium and vomeronasal organ throughout development. Expressed in both immature and mature olfactory sensory neurons in the olfactory epithelium (at protein level). First expressed at embryonic day (E) 11.5 in the olfactory epithelium and at 13.5 dpc in the vomeronasal organ. Expression increases thereafter, reached maximal level at P14, and strong expression level is maintained into adulthood. Various olfactory phenotypes, such as abnormal localization of ADCY3, shortened olfactory cilia, and reduced electrophysiological and behavioral sensitivities to odorants. Golgi membrane molecular_function Golgi apparatus sensory perception of smell membrane integral component of membrane integral component of Golgi membrane response to stimulus protein localization to non-motile cilium non-motile cilium assembly uc012fkd.1 uc012fkd.2 uc012fkd.3 
ENSMUST00000179446.2 Gm23860 ENSMUST00000179446.2 Gm23860 (from geneSymbol) ENSMUST00000179446.1 uc290lbp.1 uc290lbp.2 uc290lbp.1 uc290lbp.2 
ENSMUST00000179466.2 Btbd35f6 ENSMUST00000179466.2 BTB domain containing 35, family member 6 (from RefSeq NM_001374720.1) Btbd35f6 ENSMUST00000179466.1 Gm2964 J3QMW9 J3QMW9_MOUSE NM_001374720 uc292nqy.1 uc292nqy.2 molecular_function cellular_component biological_process uc292nqy.1 uc292nqy.2 
ENSMUST00000179468.3 Eif1ad10 ENSMUST00000179468.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. (from UniProt Q3UTA4) ENSMUST00000179468.1 ENSMUST00000179468.2 Eif1ad10 Eif1ad8 Gm8300 Gm8332 Q3UTA4 Q3UTA4_MOUSE uc288igo.1 uc288igo.2 uc288igo.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. molecular_function RNA binding translation initiation factor activity cellular_component translation translational initiation biological_process uc288igo.1 uc288igo.2 uc288igo.3 
ENSMUST00000179471.3 Gm22951 ENSMUST00000179471.3 Gm22951 (from geneSymbol) ENSMUST00000179471.1 ENSMUST00000179471.2 uc289bfr.1 uc289bfr.2 uc289bfr.1 uc289bfr.2 
ENSMUST00000179472.8 Mro ENSMUST00000179472.8 maestro, transcript variant 13 (from RefSeq NM_001403908.1) E9QNX2 E9QNX2_MOUSE ENSMUST00000179472.1 ENSMUST00000179472.2 ENSMUST00000179472.3 ENSMUST00000179472.4 ENSMUST00000179472.5 ENSMUST00000179472.6 ENSMUST00000179472.7 Mro NM_001403908 uc289ppl.1 uc289ppl.2 uc289ppl.1 uc289ppl.2 
ENSMUST00000179475.4 Gm23308 ENSMUST00000179475.4 Gm23308 (from geneSymbol) ENSMUST00000179475.1 ENSMUST00000179475.2 ENSMUST00000179475.3 uc288qft.1 uc288qft.2 uc288qft.1 uc288qft.2 
ENSMUST00000179481.2 Scgb1b3 ENSMUST00000179481.2 secretoglobin, family 1B, member 3 (from RefSeq NM_001256073.1) Abpa3 ENSMUST00000179481.1 J3QJY4 J3QJY4_MOUSE NM_001256073 Scgb1b3 uc029wep.1 uc029wep.2 Secreted steroid binding extracellular region biological_process uc029wep.1 uc029wep.2 
ENSMUST00000179484.3 Gm25618 ENSMUST00000179484.3 Gm25618 (from geneSymbol) ENSMUST00000179484.1 ENSMUST00000179484.2 uc289hyr.1 uc289hyr.2 uc289hyr.1 uc289hyr.2 
ENSMUST00000179488.3 Gpr15lg ENSMUST00000179488.3 G protein coupled receptor 15 ligand (from RefSeq NM_001206684.1) A0A0B4J1N3 ENSMUST00000179488.1 ENSMUST00000179488.2 GP15L_MOUSE Gpr15l NM_001206684 uc007tbv.1 uc007tbv.2 uc007tbv.3 uc007tbv.4 Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity). May regulate keratinocyte proliferation. In addition, through activation of Mas- related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (PubMed:35704588). Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus. Interacts with SUSD2; the interaction is direct. Secreted Highly abundant in the testis, colon, eye, and tongue. Detected in the epithelial layer of the colon, but not the small intestine. Up-regulated by Imiquimod in the skin. Gpr15lg deficient mice in an imiquimod-induced psoriasiform dermatitis model develop less intense itch phenotype than wild type 1 day after imiquimod treatment and afterward, and display less severe capillary leakage and less skin hyperplasia after 5-day imiquimod treatment. G-protein coupled receptor binding cytokine activity cellular_component extracellular region extracellular space chemotaxis G-protein coupled receptor signaling pathway chemokine activity defense response to bacterium receptor agonist activity lymphocyte chemotaxis defense response to Gram-positive bacterium defense response to fungus negative regulation of cell division negative regulation of cell cycle G1/S phase transition regulation of T cell migration uc007tbv.1 uc007tbv.2 uc007tbv.3 uc007tbv.4 
ENSMUST00000179489.8 Efl1 ENSMUST00000179489.8 elongation factor like GTPase 1, transcript variant 2 (from RefSeq NM_001159672.1) EFL1_MOUSE ENSMUST00000179489.1 ENSMUST00000179489.2 ENSMUST00000179489.3 ENSMUST00000179489.4 ENSMUST00000179489.5 ENSMUST00000179489.6 ENSMUST00000179489.7 Eftud1 NM_001159672 Q80W46 Q8C0D5 Q8C198 Q8K0B8 uc009idf.1 uc009idf.2 uc009idf.3 Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits (By similarity). Associates with the 60S ribosomal subunit. Found in a complex consisting of the 60S ribosomal subunit, SBDS and EFL1. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. nucleotide binding translation elongation factor activity GTPase activity GTP binding cytosol translation translational elongation ribosome biogenesis mature ribosome assembly ribosome binding GTP metabolic process ribonucleoprotein complex uc009idf.1 uc009idf.2 uc009idf.3 
ENSMUST00000179490.2 Gm13287 ENSMUST00000179490.2 predicted gene 13287 (from RefSeq NM_001161610.1) B1AYI3 B1AYI3_MOUSE ENSMUST00000179490.1 Gm13272 Gm13285 Gm13287 If1ha7 NM_001161610 uc012dgw.1 uc012dgw.2 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc012dgw.1 uc012dgw.2 
ENSMUST00000179505.8 ENSMUSG00000095041 ENSMUST00000179505.8 ENSMUSG00000095041 (from geneSymbol) AK168892 ENSMUST00000179505.1 ENSMUST00000179505.2 ENSMUST00000179505.3 ENSMUST00000179505.4 ENSMUST00000179505.5 ENSMUST00000179505.6 ENSMUST00000179505.7 uc292muc.1 uc292muc.2 uc292muc.1 uc292muc.2 
ENSMUST00000179511.2 Vmn1r111 ENSMUST00000179511.2 vomeronasal 1 receptor 111 (from RefSeq NM_001166746.1) D3YTY2 D3YTY2_MOUSE ENSMUST00000179511.1 NM_001166746 Vmn1r111 Vmn1r131 Vmn1r138 Vmn1r166 uc012fcg.1 uc012fcg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to stimulus sensory perception of taste uc012fcg.1 uc012fcg.2 
ENSMUST00000179512.3 Trav13d-3 ENSMUST00000179512.3 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt J3QMG8) ENSMUST00000179512.1 ENSMUST00000179512.2 J3QMG8 J3QMG8_MOUSE Trav13d-3 Trav13n-3 U23509 uc288tyc.1 uc288tyc.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc288tyc.1 uc288tyc.2 
ENSMUST00000179520.2 Ighd4-1 ENSMUST00000179520.2 Ighd4-1 (from geneSymbol) ENSMUST00000179520.1 uc288jse.1 uc288jse.2 uc288jse.1 uc288jse.2 
ENSMUST00000179529.2 Astx1a ENSMUST00000179529.2 Astx1a (from geneSymbol) DQ874390 ENSMUST00000179529.1 uc292qja.1 uc292qja.2 uc292qja.1 uc292qja.2 
ENSMUST00000179532.2 Btbd35f29 ENSMUST00000179532.2 Btbd35f29 (from geneSymbol) Btbd35f29 ENSMUST00000179532.1 J3QML3 J3QML3_MOUSE uc292npx.1 uc292npx.2 uc292npx.1 uc292npx.2 
ENSMUST00000179539.9 Dynlt2a2 ENSMUST00000179539.9 dynein light chain Tctex-type 2A2, transcript variant 2 (from RefSeq NM_001360662.1) A0A0R4J284 A0A0R4J284_MOUSE Dynlt2a1 Dynlt2a2 ENSMUST00000179539.1 ENSMUST00000179539.2 ENSMUST00000179539.3 ENSMUST00000179539.4 ENSMUST00000179539.5 ENSMUST00000179539.6 ENSMUST00000179539.7 ENSMUST00000179539.8 NM_001360662 uc008ans.1 uc008ans.2 uc008ans.3 uc008ans.4 This gene is one of three genes with a very high degree of similarity to each other within a 77 kb genomic span on Chromosome 17 A2. This gene lies between the other two gene copies. [provided by RefSeq, Jul 2008]. Belongs to the dynein light chain Tctex-type family. molecular_function cellular_component biological_process uc008ans.1 uc008ans.2 uc008ans.3 uc008ans.4 
ENSMUST00000179543.8 Noc2l ENSMUST00000179543.8 NOC2 like nucleolar associated transcriptional repressor, transcript variant 3 (from RefSeq NR_161236.2) ENSMUST00000179543.1 ENSMUST00000179543.2 ENSMUST00000179543.3 ENSMUST00000179543.4 ENSMUST00000179543.5 ENSMUST00000179543.6 ENSMUST00000179543.7 J3QK52 J3QK52_MOUSE NR_161236 Noc2l uc029vbh.1 uc029vbh.2 Belongs to the NOC2 family. negative regulation of transcription from RNA polymerase II promoter negative regulation of B cell apoptotic process chromatin binding transcription corepressor activity nucleus nucleoplasm nucleolus cytosol nucleosome binding chromatin assembly cellular response to UV negative regulation of histone acetylation histone binding repressing transcription factor binding negative regulation of intrinsic apoptotic signaling pathway uc029vbh.1 uc029vbh.2 
ENSMUST00000179549.3 Ccdc85b ENSMUST00000179549.3 coiled-coil domain containing 85B, transcript variant 1 (from RefSeq NM_198616.4) CC85B_MOUSE Dipa ENSMUST00000179549.1 ENSMUST00000179549.2 NM_198616 Q6PDY0 uc012bgx.1 uc012bgx.2 uc012bgx.3 uc012bgx.4 uc012bgx.5 Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (PubMed:15644333, PubMed:22666460). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). Interacts with CEBPB (PubMed:15644333). May interact with CEBPD (Probable). Interacts with EURL (PubMed:27404227). Interacts with MCRS1 (By similarity). Interacts with TCF7L2; competes with CTNNB1 (By similarity). Interacts with ANKRD26 (By similarity). Interacts with the beta-catenin family proteins ARVCF, CTNND1, CTNND2 and PKP4 (By similarity). Nucleus toplasm, cytoskeleton, microtubule organizing center, centrosome Cell junction, adherens junction Expressed in white and brown adipose tissue. Belongs to the CCDC85 family. protein binding nucleus cytoplasm centrosome microtubule organizing center cytoskeleton cell differentiation negative regulation of cell growth regulation of growth negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated uc012bgx.1 uc012bgx.2 uc012bgx.3 uc012bgx.4 uc012bgx.5 
ENSMUST00000179550.2 S100a2 ENSMUST00000179550.2 S100 calcium binding protein A2 (from RefSeq NM_001195760.1) ENSMUST00000179550.1 J3QMC7 J3QMC7_MOUSE NM_001195760 S100a2 uc012cta.1 uc012cta.2 molecular_function cellular_component uc012cta.1 uc012cta.2 
ENSMUST00000179554.3 Dynlt1f ENSMUST00000179554.3 dynein light chain Tctex-type 1F, transcript variant 2 (from RefSeq NM_001199948.1) DYLT1_MOUSE Dynlt1 ENSMUST00000179554.1 ENSMUST00000179554.2 NM_001199948 P51807 Q5M8S6 Tctel1 Tctex-1 Tctex1 uc008agz.1 uc008agz.2 uc008agz.3 uc008agz.4 uc008agz.5 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia (By similarity). May also be a accessory component of axonemal dynein. Plays an important role in male germ cell development and function. Candidate for involvement in male sterility. Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta- gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling. Involved in the regulation of mitotic spindle orientation. Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non- catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with RHO (By similarity). Interacts with DYNC1I1 and DYNC1I2. Interacts with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2. Interacts with GNB1; the interaction occurs in presence of guanine nucleotide- binding protein G(T) subunit gamma; the interaction diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the interactions occur in presence of guanine nucleotide-binding protein G(T) subunit gamma. Interacts with ACVR2B and ARHGEF2 (By similarity). Interacts with DNAI4 (PubMed:30060180). P51807; P39688: Fyn; NbExp=3; IntAct=EBI-642797, EBI-524514; P51807; O46385: SVIL; Xeno; NbExp=4; IntAct=EBI-642797, EBI-6995105; Golgi apparatus Cytoplasm Cytoplasm, cytoskeleton, spindle Note=Localizes to mitotic spindles. High level in testis (germ cell-specific). Expressed in sperm (at protein level). 200-fold lower in liver, brain, heart, spleen, and kidney. Levels in thymus and two embryonal carcinoma cell lines were several-fold higher than this low constitutive level. First abundantly expressed at the pachytene stage of meiosis and persists throughout spermatogenesis. Phosphorylated by BMPR2. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release (By similarity). Belongs to the dynein light chain Tctex-type family. establishment of mitotic spindle orientation photoreceptor inner segment motor activity protein binding cytoplasm Golgi apparatus spindle cytoskeleton cytoplasmic dynein complex microtubule cytoplasmic microtubule cell cycle nervous system development protein C-terminus binding regulation of G-protein coupled receptor protein signaling pathway positive regulation of neuron projection development lamellipodium dynein complex growth cone GTP-dependent protein binding G-protein beta-subunit binding identical protein binding neuronal cell body axonal growth cone cell body negative regulation of neurogenesis cell division negative regulation of ERK1 and ERK2 cascade secretory vesicle uc008agz.1 uc008agz.2 uc008agz.3 uc008agz.4 uc008agz.5 
ENSMUST00000179555.8 Zfp518b ENSMUST00000179555.8 zinc finger protein 518B, transcript variant 4 (from RefSeq NM_001408032.1) ENSMUST00000179555.1 ENSMUST00000179555.2 ENSMUST00000179555.3 ENSMUST00000179555.4 ENSMUST00000179555.5 ENSMUST00000179555.6 ENSMUST00000179555.7 J3QPN0 J3QPN0_MOUSE NM_001408032 Zfp518b uc012dvr.1 uc012dvr.2 nucleic acid binding uc012dvr.1 uc012dvr.2 
ENSMUST00000179556.2 Zfp574 ENSMUST00000179556.2 zinc finger protein 574, transcript variant 1 (from RefSeq NM_175477.5) ENSMUST00000179556.1 NM_175477 Q3TDE5 Q3UNU1 Q8BKB5 Q8BY46 ZN574_MOUSE Znf574 uc009frj.1 uc009frj.2 uc009frj.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAC35502.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding nucleus biological_process metal ion binding uc009frj.1 uc009frj.2 uc009frj.3 
ENSMUST00000179560.2 Ighd2-4 ENSMUST00000179560.2 Ighd2-4 (from geneSymbol) ENSMUST00000179560.1 uc288jst.1 uc288jst.2 uc288jst.1 uc288jst.2 
ENSMUST00000179568.3 Amy2a4 ENSMUST00000179568.3 amylase 2a1 (from RefSeq NM_001411494.1) AM2A5_MOUSE Amy2 Amy2a Amy2a5 ENSMUST00000179568.1 ENSMUST00000179568.2 NM_001411494 P00688 Q4VBW6 Q61295 Q61296 Q64301 uc008rax.1 uc008rax.2 uc008rax.3 uc008rax.4 Reaction=Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D- glucose units.; EC=3.2.1.1; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 1 Ca(2+) ion per subunit. ; Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence=; Note=Binds 1 Cl(-) ion per subunit. ; Monomer. Secreted, extracellular space. Belongs to the glycosyl hydrolase 13 family. catalytic activity alpha-amylase activity calcium ion binding extracellular region extracellular space carbohydrate metabolic process metabolic process carbohydrate catabolic process amylase activity hydrolase activity hydrolase activity, acting on glycosyl bonds chloride ion binding cation binding metal ion binding uc008rax.1 uc008rax.2 uc008rax.3 uc008rax.4 
ENSMUST00000179569.3 Dynlt1b ENSMUST00000179569.3 dynein light chain Tctex-type 1B (from RefSeq NM_009342.2) DYLT1_MOUSE Dynlt1 ENSMUST00000179569.1 ENSMUST00000179569.2 NM_009342 P51807 Q5M8S6 Tctel1 Tctex-1 Tctex1 uc008agq.1 uc008agq.2 uc008agq.3 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia (By similarity). May also be a accessory component of axonemal dynein. Plays an important role in male germ cell development and function. Candidate for involvement in male sterility. Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta- gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling. Involved in the regulation of mitotic spindle orientation. Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non- catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with RHO (By similarity). Interacts with DYNC1I1 and DYNC1I2. Interacts with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2. Interacts with GNB1; the interaction occurs in presence of guanine nucleotide- binding protein G(T) subunit gamma; the interaction diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the interactions occur in presence of guanine nucleotide-binding protein G(T) subunit gamma. Interacts with ACVR2B and ARHGEF2 (By similarity). Interacts with DNAI4 (PubMed:30060180). P51807; P39688: Fyn; NbExp=3; IntAct=EBI-642797, EBI-524514; P51807; O46385: SVIL; Xeno; NbExp=4; IntAct=EBI-642797, EBI-6995105; Golgi apparatus Cytoplasm Cytoplasm, cytoskeleton, spindle Note=Localizes to mitotic spindles. High level in testis (germ cell-specific). Expressed in sperm (at protein level). 200-fold lower in liver, brain, heart, spleen, and kidney. Levels in thymus and two embryonal carcinoma cell lines were several-fold higher than this low constitutive level. First abundantly expressed at the pachytene stage of meiosis and persists throughout spermatogenesis. Phosphorylated by BMPR2. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release (By similarity). Belongs to the dynein light chain Tctex-type family. establishment of mitotic spindle orientation photoreceptor inner segment motor activity protein binding cytoplasm Golgi apparatus spindle cytoskeleton cytoplasmic dynein complex microtubule cytoplasmic microtubule cell cycle nervous system development protein C-terminus binding regulation of G-protein coupled receptor protein signaling pathway positive regulation of neuron projection development lamellipodium dynein complex growth cone GTP-dependent protein binding G-protein beta-subunit binding identical protein binding neuronal cell body axonal growth cone cell body negative regulation of neurogenesis cell division negative regulation of ERK1 and ERK2 cascade secretory vesicle uc008agq.1 uc008agq.2 uc008agq.3 
ENSMUST00000179573.2 A630095N17Rik ENSMUST00000179573.2 RIKEN cDNA A630095N17 gene, transcript variant 2 (from RefSeq NM_001243091.1) A630095N17Rik ENSMUST00000179573.1 J3QMK5 J3QMK5_MOUSE NM_001243091 uc007bol.1 uc007bol.2 molecular_function cellular_component biological_process uc007bol.1 uc007bol.2 
ENSMUST00000179578.3 Gm26296 ENSMUST00000179578.3 Gm26296 (from geneSymbol) ENSMUST00000179578.1 ENSMUST00000179578.2 LF200254 uc288yoj.1 uc288yoj.2 uc288yoj.1 uc288yoj.2 
ENSMUST00000179580.3 Trav13n-3 ENSMUST00000179580.3 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt J3QMG8) ENSMUST00000179580.1 ENSMUST00000179580.2 J3QMG8 J3QMG8_MOUSE Trav13d-3 Trav13n-3 uc288tzr.1 uc288tzr.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc288tzr.1 uc288tzr.2 
ENSMUST00000179583.3 Trav12n-3 ENSMUST00000179583.3 Trav12n-3 (from geneSymbol) A0A075B6A4 A0A075B6A4_MOUSE A0N8Q8 ENSMUST00000179583.1 ENSMUST00000179583.2 Trav12d-3 Trav12n-3 uc288tzf.1 uc288tzf.2 immunoglobulin production extracellular space immune response uc288tzf.1 uc288tzf.2 
ENSMUST00000179594.2 Vmn1r165 ENSMUST00000179594.2 vomeronasal 1 receptor 165 (from RefSeq NM_001166850.1) D3YTY1 D3YTY1_MOUSE ENSMUST00000179594.1 NM_001166850 Vmn1r107 Vmn1r130 Vmn1r137 Vmn1r155 Vmn1r165 uc012fer.1 uc012fer.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012fer.1 uc012fer.2 
ENSMUST00000179598.4 Zbed6 ENSMUST00000179598.4 zinc finger, BED type containing 6, transcript variant 2 (from RefSeq NM_001395904.1) ENSMUST00000179598.1 ENSMUST00000179598.2 ENSMUST00000179598.3 G0LE24 G0LE24_MOUSE NM_001395904 Zbed6 uc287lun.1 uc287lun.2 Nucleus DNA binding protein dimerization activity uc287lun.1 uc287lun.2 
ENSMUST00000179600.8 Xlr5a ENSMUST00000179600.8 Belongs to the XLR/SYCP3 family. (from UniProt A2BI45) A2BI45 A2BI45_MOUSE BC051681 ENSMUST00000179600.1 ENSMUST00000179600.2 ENSMUST00000179600.3 ENSMUST00000179600.4 ENSMUST00000179600.5 ENSMUST00000179600.6 ENSMUST00000179600.7 Xlr5a Xlr5b uc292oqe.1 uc292oqe.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc292oqe.1 uc292oqe.2 
ENSMUST00000179607.3 Trav6n-7 ENSMUST00000179607.3 Trav6n-7 (from geneSymbol) A0A075B6A6 A0A075B6A6_MOUSE ENSMUST00000179607.1 ENSMUST00000179607.2 Trav6n-7 X52448 uc029sjs.1 uc029sjs.2 uc029sjs.3 uc029sjs.4 immunoglobulin production extracellular space immune response uc029sjs.1 uc029sjs.2 uc029sjs.3 uc029sjs.4 
ENSMUST00000179611.2 ENSMUSG00000121624 ENSMUST00000179611.2 ENSMUSG00000121624 (from geneSymbol) AB344662 ENSMUST00000179611.1 uc287vbl.1 uc287vbl.2 uc287vbl.1 uc287vbl.2 
ENSMUST00000179619.9 Adgrg1 ENSMUST00000179619.9 adhesion G protein-coupled receptor G1, transcript variant 20 (from RefSeq NM_001403785.1) AGRG1_MOUSE Adgrg1 Cyt28 ENSMUST00000179619.1 ENSMUST00000179619.2 ENSMUST00000179619.3 ENSMUST00000179619.4 ENSMUST00000179619.5 ENSMUST00000179619.6 ENSMUST00000179619.7 ENSMUST00000179619.8 Gpr56 NM_001403785 Q3UR17 Q8K209 Q9QZT2 uc009mxl.1 uc009mxl.2 uc009mxl.3 uc009mxl.4 Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (PubMed:21768377). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (By similarity). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (PubMed:23478665). Plays a critical role in tumourigenesis (By similarity). Plays essential role in testis development (PubMed:20981830). ADGRG1 NT is proposed to inhibit receptor signaling; its interactions with extracellular ligands and /or homophilic ADGRG1 NT interactions may relieve the inhibition. Following ligand binding to the N-terminal fragment, the N-terminal fragment is released from the seven-transmembrane C-terminal fragment to unveil a new N-terminal stalk, which then stimulates G-protein-dependent signaling activity. The N-terminal stalk has also been shown to be dispensable for at least some G-protein-dependent signaling. Predominantly non-covalently linked heterodimer of the N- terminal and the C-terminal fragment. ADGRG1 NT self-associates in a trans-trans manner; the homophilic interaction enhances receptor signaling. ADGRG1 CT interacts with ARRB2; the interaction is impaired by ADGRG1 NT. Part of a GPCR-tetraspanin complex at least consisting of ADGRG1, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of ADGRG1 with GNA11 (By similarity). Interacts with heparin; leading to the reduction of ADGRG1 shedding (PubMed:27068534). Interacts with COL3A1 (By similarity). Q8K209; Q80TR1: Adgrl1; NbExp=2; IntAct=EBI-6856929, EBI-770649; Cell membrane ulti-pass membrane protein [ADGRG1 N-terminal fragment]: Secreted [ADGRG1 C-terminal fragment]: Membrane raft Note=Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of ADGRG1 CT with lipid rafts. Expressed in neural progenitor cells in fetal forbrain. Expressed in migrating neurons. Expressed in radial glial endfeet (at protein level) (PubMed:21768377). Expressed in peritubular myoid cells, Sertoli cells, and germ cells of the testis (PubMed:20981830). Autoproteolytically cleaved into 2 fragments; the large extracellular N-terminal fragment and the membroune-bound C-terminal fragment predominantly remain associated and non-covalently linked. N-glycosylated. The secreted ADGRG1 N-terminal fragment is heavily glycosylated. Ubiquitinated. Undergoes polyubiquitination upon activation. Cobblestone-like cortical malformation with defective pial basement membrane (BM), abnormal anchorage of radial glial endfeet, mislocalized Cajal-Retzius cells and neuronal overmigration. Severe malformation of the rostral cerebellum that develops perinatally. Granule cells from the rostral region show loss of adhesion to extracellular matrix molecules of the pial basement membrane. In ADGRG1 knockout mice, neurons overmigrate through breached pial basement membrane or undermigrate forming irregular cortical layers. Deficient mice shown disruption of seminiferous tubule formation and increased sterility (PubMed:20981830). Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. angiogenesis transmembrane signaling receptor activity G-protein coupled receptor activity collagen binding extracellular region plasma membrane integral component of plasma membrane cell adhesion signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway Rho protein signal transduction multicellular organism development nervous system development brain development heparin binding negative regulation of cell proliferation vascular endothelial growth factor production membrane integral component of membrane cell migration cerebral cortex regionalization cerebral cortex radial glia guided migration layer formation in cerebral cortex cell differentiation positive regulation of Rho protein signal transduction membrane raft positive regulation of cell adhesion extracellular matrix binding protein kinase C signaling seminiferous tubule development glial limiting end-foot positive regulation of neural precursor cell proliferation negative regulation of neuron migration uc009mxl.1 uc009mxl.2 uc009mxl.3 uc009mxl.4 
ENSMUST00000179626.3 Rhox5 ENSMUST00000179626.3 Rhox5 (from geneSymbol) DQ058642 ENSMUST00000179626.1 ENSMUST00000179626.2 J3QPX1 J3QPX1_MOUSE Rhox5 uc292nut.1 uc292nut.2 uc292nut.1 uc292nut.2 
ENSMUST00000179636.3 Slc6a15 ENSMUST00000179636.3 solute carrier family 6 (neurotransmitter transporter), member 15, transcript variant c (from RefSeq NM_001358821.1) B0at2 ENSMUST00000179636.1 ENSMUST00000179636.2 NM_001358821 Ntt73 Q333Y0 Q8BG16 S6A15_MOUSE uc007gyk.1 uc007gyk.2 uc007gyk.3 uc007gyk.4 Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for methionine and for the branched- chain amino acids, particularly leucine, valine and isoleucine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid (PubMed:16185194). Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity). Reaction=L-pipecolate(in) + Na(+)(in) = L-pipecolate(out) + Na(+)(out); Xref=Rhea:RHEA:71387, ChEBI:CHEBI:29101, ChEBI:CHEBI:61185; Evidence=; Reaction=L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out); Xref=Rhea:RHEA:29263, ChEBI:CHEBI:29101, ChEBI:CHEBI:57427; Evidence=; Reaction=L-isoleucine(in) + Na(+)(in) = L-isoleucine(out) + Na(+)(out); Xref=Rhea:RHEA:29275, ChEBI:CHEBI:29101, ChEBI:CHEBI:58045; Evidence=; Reaction=L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out); Xref=Rhea:RHEA:68240, ChEBI:CHEBI:29101, ChEBI:CHEBI:57844; Evidence=; Reaction=L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out); Xref=Rhea:RHEA:28967, ChEBI:CHEBI:29101, ChEBI:CHEBI:60039; Evidence=; Reaction=L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out); Xref=Rhea:RHEA:29283, ChEBI:CHEBI:29101, ChEBI:CHEBI:57972; Evidence=; Reaction=L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out); Xref=Rhea:RHEA:71383, ChEBI:CHEBI:29101, ChEBI:CHEBI:58048; Evidence=; Reaction=L-valine(in) + Na(+)(in) = L-valine(out) + Na(+)(out); Xref=Rhea:RHEA:29267, ChEBI:CHEBI:29101, ChEBI:CHEBI:57762; Evidence=; Reaction=L-cysteine(in) + Na(+)(in) = L-cysteine(out) + Na(+)(out); Xref=Rhea:RHEA:68232, ChEBI:CHEBI:29101, ChEBI:CHEBI:35235; Evidence=; Reaction=L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out); Xref=Rhea:RHEA:68236, ChEBI:CHEBI:29101, ChEBI:CHEBI:58359; Evidence=; Reaction=L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out); Xref=Rhea:RHEA:29575, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384; Evidence=; Reaction=L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out); Xref=Rhea:RHEA:69999, ChEBI:CHEBI:29101, ChEBI:CHEBI:57926; Evidence=; Reaction=L-phenylalanine(in) + Na(+)(in) = L-phenylalanine(out) + Na(+)(out); Xref=Rhea:RHEA:68244, ChEBI:CHEBI:29101, ChEBI:CHEBI:58095; Evidence=; Kinetic parameters: KM=195 uM for proline (in the presence of 100 mM NaCL) ; KM=510 uM for proline (in the presence of 30 mM NaCL) ; KM=790 uM for proline (in the presence of 3 mM NaCL) ; KM=81 uM for leucine ; KM=58 uM for isoleucine ; KM=40 uM for methionine ; KM=670 uM for alanine ; KM=900 uM for pipecolate ; pH dependence: Optimum pH is 7.5-8.5. ; Membrane ; Multi- pass membrane protein Significant expressed in brain, lung and kidney. In brain, mainly expressed int the cortex, the cerebellum and the brain stem. Detected throughout development, starting with the pre-implantation embryo. Mice are viable and fertile and fail to demonstrate any striking abnormality in motor and sensory functions. Other transporters could help to compensate for lost of SLC6A15. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily. amino acid transmembrane transport proline:sodium symporter activity neurotransmitter:sodium symporter activity plasma membrane integral component of plasma membrane ion transport sodium ion transport neurotransmitter transport amino acid transport symporter activity neutral amino acid transport leucine transport proline transport membrane integral component of membrane transmembrane transport organic acid transmembrane transport uc007gyk.1 uc007gyk.2 uc007gyk.3 uc007gyk.4 
ENSMUST00000179642.3 Gm26097 ENSMUST00000179642.3 Gm26097 (from geneSymbol) ENSMUST00000179642.1 ENSMUST00000179642.2 uc291qut.1 uc291qut.2 uc291qut.1 uc291qut.2 
ENSMUST00000179657.2 Ighv2-6 ENSMUST00000179657.2 Ighv2-6 (from geneSymbol) A0A075B6A7 A0A075B6A7_MOUSE ENSMUST00000179657.1 EU330527 Ighv2-6 uc288jty.1 uc288jty.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jty.1 uc288jty.2 
ENSMUST00000179659.2 Gm3317 ENSMUST00000179659.2 predicted gene 3317 (from RefSeq NM_001242941.2) A6NAT8 A6NAT8_MOUSE ENSMUST00000179659.1 Gm3317 NM_001242941 uc288qlo.1 uc288qlo.2 uc288qlo.1 uc288qlo.2 
ENSMUST00000179669.3 Foxg1 ENSMUST00000179669.3 forkhead box G1, transcript variant 2 (from RefSeq NM_001160112.1) ENSMUST00000179669.1 ENSMUST00000179669.2 FOXG1_MOUSE Fkhl1 Foxg1b Hfhbf1 NM_001160112 Q60987 Q80VP3 uc011ylr.1 uc011ylr.2 uc011ylr.3 Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. Interacts with KDM5B (By similarity). Interacts with GRG6/TLE6 (PubMed:16314515). Interacts with TLE1; the interaction is inhibited by interaction with TLE6/GRG6 (PubMed:16314515). Q60987; Q9Z2D6-1: Mecp2; NbExp=4; IntAct=EBI-11166131, EBI-26609102; Q60987; Q9Z2D6-2: Mecp2; NbExp=2; IntAct=EBI-11166131, EBI-26609115; Q60987; O43524: FOXO3; Xeno; NbExp=5; IntAct=EBI-11166131, EBI-1644164; Nucleus CNS, and nasal half of the retina. negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding positive regulation of neuroblast proliferation DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm regulation of transcription, DNA-templated multicellular organism development regulation of mitotic cell cycle brain development aging dorsal/ventral pattern formation regulation of gene expression axon midline choice point recognition pyramidal neuron migration central nervous system neuron development cerebral cortex development neurogenesis forebrain development inner ear morphogenesis sequence-specific DNA binding negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of cell cycle negative regulation of transcription, DNA-templated neuron fate determination cell morphogenesis involved in neuron differentiation regulation of cell cycle regulation of neural precursor cell proliferation uc011ylr.1 uc011ylr.2 uc011ylr.3 
ENSMUST00000179675.3 Gm22317 ENSMUST00000179675.3 Gm22317 (from geneSymbol) ENSMUST00000179675.1 ENSMUST00000179675.2 FM991912 uc288gjb.1 uc288gjb.2 uc288gjb.1 uc288gjb.2 
ENSMUST00000179676.2 Gm19967 ENSMUST00000179676.2 Gm19967 (from geneSymbol) ENSMUST00000179676.1 uc287zsz.1 uc287zsz.2 uc287zsz.1 uc287zsz.2 
ENSMUST00000179677.2 ENSMUSG00000094791 ENSMUST00000179677.2 ENSMUSG00000094791 (from geneSymbol) BC052888 ENSMUST00000179677.1 uc291cfn.1 uc291cfn.2 uc291cfn.1 uc291cfn.2 
ENSMUST00000179685.3 Smlr1 ENSMUST00000179685.3 small leucine-rich protein 1 (from RefSeq NM_001195596.1) 2010003K15Rik ENSMUST00000179685.1 ENSMUST00000179685.2 J3QMJ4 J3QMJ4_MOUSE NM_001195596 Smlr1 uc007erv.1 uc007erv.2 uc007erv.3 uc007erv.4 molecular_function cellular_component biological_process membrane integral component of membrane uc007erv.1 uc007erv.2 uc007erv.3 uc007erv.4 
ENSMUST00000179688.3 Scgb2b19 ENSMUST00000179688.3 secretoglobin, family 2B, member 19 (from RefSeq NM_001199336.1) Abpbg19 ENSMUST00000179688.1 ENSMUST00000179688.2 J3QM75 J3QM75_MOUSE NM_001199336 Scgb2b19 uc012fid.1 uc012fid.2 uc012fid.3 Secreted Belongs to the secretoglobin family. molecular_function cellular_component extracellular space biological_process uc012fid.1 uc012fid.2 uc012fid.3 
ENSMUST00000179700.2 ENSMUSG00000094887 ENSMUST00000179700.2 ENSMUSG00000094887 (from geneSymbol) BC083101 C87414 ENSMUST00000179700.1 Pramel34 Q5XK27 Q5XK27_MOUSE uc029vte.1 uc029vte.2 uc029vte.3 uc029vte.4 molecular_function cytoplasm biological_process uc029vte.1 uc029vte.2 uc029vte.3 uc029vte.4 
ENSMUST00000179701.2 Trav5d-4 ENSMUST00000179701.2 Trav5d-4 (from geneSymbol) ENSMUST00000179701.1 Q5R1F6 Q5R1F6_MOUSE TRAV5D-4 Trav5d-4 Trav5n-4 uc288txz.1 uc288txz.2 uc288txz.1 uc288txz.2 
ENSMUST00000179707.3 Krtap16-3 ENSMUST00000179707.3 keratin associated protein 16-3 (from RefSeq NM_183296.1) ENSMUST00000179707.1 ENSMUST00000179707.2 KR163_MOUSE Krtap16-10 Krtap16.3 NM_183296 Q3B7Z5 Q8C1I6 Q925H8 uc012ahw.1 uc012ahw.2 uc012ahw.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Strong expression in narrowly defined pattern restricted to the lower and middle cortical regions of the hair shaft in both developing and cycling hair. During hair follicle regression (catagen), expression levels decrease until expression is no longer detectable in follicles at resting stage (telogen). Expression in skin and hair follicle is regulated by HOXC13 and by GATA3. Belongs to the KRTAP type 16 family. Sequence=AAK52891.1; Type=Frameshift; Evidence=; molecular_function cellular_component intermediate filament biological_process uc012ahw.1 uc012ahw.2 uc012ahw.3 
ENSMUST00000179715.2 ENSMUSG00000094915 ENSMUST00000179715.2 ENSMUSG00000094915 (from geneSymbol) AK156902 ENSMUST00000179715.1 uc289spi.1 uc289spi.2 uc289spi.1 uc289spi.2 
ENSMUST00000179721.8 Phlpp2 ENSMUST00000179721.8 PH domain and leucine rich repeat protein phosphatase 2 (from RefSeq NM_001122594.2) ENSMUST00000179721.1 ENSMUST00000179721.2 ENSMUST00000179721.3 ENSMUST00000179721.4 ENSMUST00000179721.5 ENSMUST00000179721.6 ENSMUST00000179721.7 J3QM82 J3QM82_MOUSE NM_001122594 Phlpp2 uc009njn.1 uc009njn.2 uc009njn.3 uc009njn.4 photoreceptor inner segment catalytic activity protein serine/threonine phosphatase activity cytoplasm protein dephosphorylation hippocampus development photoreceptor outer segment membrane uc009njn.1 uc009njn.2 uc009njn.3 uc009njn.4 
ENSMUST00000179723.2 Astx5 ENSMUST00000179723.2 amplified spermatogenic transcripts X encoded 5 (from RefSeq NR_152851.1) ENSMUST00000179723.1 NR_152851 uc292qiv.1 uc292qiv.2 uc292qiv.1 uc292qiv.2 
ENSMUST00000179725.3 Gm13285 ENSMUST00000179725.3 predicted gene 13285 (from RefSeq NM_001161609.1) B1AYI3 B1AYI3_MOUSE ENSMUST00000179725.1 ENSMUST00000179725.2 Gm13272 Gm13285 Gm13287 If1ha7 NM_001161609 uc008tnv.1 uc008tnv.2 uc008tnv.3 uc008tnv.4 uc008tnv.5 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc008tnv.1 uc008tnv.2 uc008tnv.3 uc008tnv.4 uc008tnv.5 
ENSMUST00000179726.2 Krtap12-20 ENSMUST00000179726.2 predicted gene 10100 (from RefSeq NM_001205033.2) ENSMUST00000179726.1 Gm10100 J3QK64 J3QK64_MOUSE NM_001205033 uc029qzp.1 uc029qzp.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc029qzp.1 uc029qzp.2 
ENSMUST00000179728.2 Rnaset2b ENSMUST00000179728.2 Lysosome lumen (from UniProt Q5FWA0) AK029149 ENSMUST00000179728.1 Q5FWA0 Q5FWA0_MOUSE Rnaset2b uc289guj.1 uc289guj.2 Lysosome lumen Belongs to the RNase T2 family. RNA binding membrane integral component of membrane ribonuclease T2 activity RNA phosphodiester bond hydrolysis, endonucleolytic uc289guj.1 uc289guj.2 
ENSMUST00000179735.3 Alyreffm12 ENSMUST00000179735.3 Alyreffm12 (from geneSymbol) ENSMUST00000179735.1 ENSMUST00000179735.2 Gm4301 Gm4308 Gm4312 K9J7E2 K9J7E2_MOUSE uc287ums.1 uc287ums.2 uc287ums.3 molecular_function nucleic acid binding RNA binding cellular_component biological_process uc287ums.1 uc287ums.2 uc287ums.3 
ENSMUST00000179743.4 Pramel38 ENSMUST00000179743.4 Belongs to the PRAME family. (from UniProt J3QPH3) BC061196 ENSMUST00000179743.1 ENSMUST00000179743.2 ENSMUST00000179743.3 J3QPH3 J3QPH3_MOUSE Pramel38 uc290xfe.1 uc290xfe.2 uc290xfe.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xfe.1 uc290xfe.2 uc290xfe.3 
ENSMUST00000179751.3 Plscr5 ENSMUST00000179751.3 phospholipid scramblase family, member 5 (from RefSeq NM_001195693.2) ENSMUST00000179751.1 ENSMUST00000179751.2 J3QM92 J3QM92_MOUSE NM_001195693 Plscr5 uc012gyj.1 uc012gyj.2 uc012gyj.3 May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= Belongs to the phospholipid scramblase family. plasma membrane phospholipid scrambling phospholipid scramblase activity uc012gyj.1 uc012gyj.2 uc012gyj.3 
ENSMUST00000179759.3 Myom1 ENSMUST00000179759.3 myomesin 1, transcript variant 2 (from RefSeq NM_001083934.1) ENSMUST00000179759.1 ENSMUST00000179759.2 MYOM1_MOUSE NM_001083934 Q546T8 Q62234 Q6PAC0 uc008dly.1 uc008dly.2 uc008dly.3 May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. May also contact myosin filaments. Also binds beta-integrins. Homodimer. Interacts with TTN/titin and PNKD (By similarity). Cytoplasm, myofibril, sarcomere, M line Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q62234-1; Sequence=Displayed; Name=2; IsoId=Q62234-2; Sequence=VSP_035664; Ubiquitously expressed in all striated muscles. Expressed in all fiber types. extraocular skeletal muscle development structural constituent of cytoskeleton cytoplasm cytoskeleton striated muscle thin filament muscle contraction structural constituent of muscle positive regulation of gene expression protein kinase A signaling kinase binding sarcomere Z disc skeletal muscle thin filament assembly skeletal muscle myosin thick filament assembly M band myosin filament identical protein binding protein homodimerization activity sarcomere organization cardiac muscle fiber development positive regulation of protein secretion actin filament binding muscle alpha-actinin binding cardiac myofibril assembly cardiac muscle tissue morphogenesis striated muscle myosin thick filament assembly uc008dly.1 uc008dly.2 uc008dly.3 
ENSMUST00000179766.3 Gpr45 ENSMUST00000179766.3 G protein-coupled receptor 45 (from RefSeq NM_053107.4) ENSMUST00000179766.1 ENSMUST00000179766.2 GPR45_MOUSE NM_053107 Q9EQQ4 uc007avd.1 uc007avd.2 uc007avd.3 uc007avd.4 Orphan receptor. May play a role in brain function. Cell membrane; Multi-pass membrane protein. Brain specific. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc007avd.1 uc007avd.2 uc007avd.3 uc007avd.4 
ENSMUST00000179767.2 Krtap12-21 ENSMUST00000179767.2 predicted gene 10142 (from RefSeq NM_001205035.2) ENSMUST00000179767.1 Gm10142 J3KMP7 J3KMP7_MOUSE NM_001205035 uc029qzo.1 uc029qzo.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc029qzo.1 uc029qzo.2 
ENSMUST00000179772.2 Gm21379 ENSMUST00000179772.2 Gm21379 (from geneSymbol) AK017055 ENSMUST00000179772.1 uc292sgr.1 uc292sgr.2 uc292sgr.1 uc292sgr.2 
ENSMUST00000179777.3 Gm19965 ENSMUST00000179777.3 Gm19965 (from geneSymbol) ENSMUST00000179777.1 ENSMUST00000179777.2 Gm19965 J3QNY8 J3QNY8_MOUSE uc287lam.1 uc287lam.2 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc287lam.1 uc287lam.2 
ENSMUST00000179782.2 Gm24978 ENSMUST00000179782.2 Gm24978 (from geneSymbol) DQ558729 ENSMUST00000179782.1 uc290lij.1 uc290lij.2 uc290lij.1 uc290lij.2 
ENSMUST00000179787.2 1600029O15Rik ENSMUST00000179787.2 RIKEN cDNA 1600029O15 gene (from RefSeq NR_033522.1) ENSMUST00000179787.1 NR_033522 uc012gul.1 uc012gul.2 uc012gul.1 uc012gul.2 
ENSMUST00000179789.4 Trav7d-3 ENSMUST00000179789.4 Trav7d-3 (from geneSymbol) AK131826 ENSMUST00000179789.1 ENSMUST00000179789.2 ENSMUST00000179789.3 Q5R1I1 Q5R1I1_MOUSE TRAV7D-3 Trav7-3 Trav7d-3 uc288two.1 uc288two.2 uc288two.1 uc288two.2 
ENSMUST00000179794.2 Gm25173 ENSMUST00000179794.2 Gm25173 (from geneSymbol) DQ558729 ENSMUST00000179794.1 uc290lnq.1 uc290lnq.2 uc290lnq.1 uc290lnq.2 
ENSMUST00000179797.3 Mtrnr2l7 ENSMUST00000179797.3 mt-Rnr2 like 7 (from RefSeq NM_001190732.1) ENSMUST00000179797.1 ENSMUST00000179797.2 Gm20594 J3QJY3 J3QJY3_MOUSE Mtrnr2l7 NM_001190732 uc012eno.1 uc012eno.2 uc012eno.3 Secreted receptor antagonist activity negative regulation of execution phase of apoptosis negative regulation of receptor activity uc012eno.1 uc012eno.2 uc012eno.3 
ENSMUST00000179799.2 Aadacl2fm3 ENSMUST00000179799.2 AADACL2 family member 3 (from RefSeq NM_001243003.1) Aadacl2fm3 ENSMUST00000179799.1 Gm8298 J3QPI0 J3QPI0_MOUSE NM_001243003 uc029umg.1 uc029umg.2 Membrane ; Single- pass type II membrane protein Belongs to the 'GDXG' lipolytic enzyme family. cellular_component catabolic process integral component of membrane hydrolase activity short-chain carboxylesterase activity carboxylic ester hydrolase activity uc029umg.1 uc029umg.2 
ENSMUST00000179801.3 Gm7694 ENSMUST00000179801.3 predicted gene 7694 (from RefSeq NM_001198955.2) ENSMUST00000179801.1 ENSMUST00000179801.2 Gm7694 J3QNH8 J3QNH8_MOUSE NM_001198955 uc011wvs.1 uc011wvs.2 uc011wvs.3 molecular_function cellular_component biological_process uc011wvs.1 uc011wvs.2 uc011wvs.3 
ENSMUST00000179802.2 Cmtm4 ENSMUST00000179802.2 CKLF-like MARVEL transmembrane domain containing 4 (from RefSeq NM_153582.5) CKLF4_MOUSE Cklfsf4 Cmtm4 ENSMUST00000179802.1 NM_153582 Q8CJ61 Q8K143 uc009nan.1 uc009nan.2 uc009nan.3 uc009nan.4 Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD- L1/CD274 from being polyubiquitinated and targeted for degradation. Interacts with PD1L1 and CMTM6. Membrane ; Multi-pass membrane protein Belongs to the chemokine-like factor family. molecular_function biological_process membrane integral component of membrane uc009nan.1 uc009nan.2 uc009nan.3 uc009nan.4 
ENSMUST00000179804.8 Cldn12 ENSMUST00000179804.8 claudin 12, transcript variant 3 (from RefSeq NM_001193660.2) CLD12_MOUSE ENSMUST00000179804.1 ENSMUST00000179804.2 ENSMUST00000179804.3 ENSMUST00000179804.4 ENSMUST00000179804.5 ENSMUST00000179804.6 ENSMUST00000179804.7 NM_001193660 Q3TM65 Q8BH13 Q9ET43 uc012dru.1 uc012dru.2 uc012dru.3 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene, along with several other family members, is expressed in the inner ear. The protein encoded by this gene and another family member, claudin 2, are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. [provided by RefSeq, Oct 2011]. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Interacts with OCLN. Cell junction, tight junction Cell membrane ; Multi-pass membrane protein Belongs to the claudin family. plasma membrane bicellular tight junction membrane integral component of membrane lateral plasma membrane calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell junction identical protein binding cell periphery uc012dru.1 uc012dru.2 uc012dru.3 
ENSMUST00000179807.3 Gm24638 ENSMUST00000179807.3 Gm24638 (from geneSymbol) ENSMUST00000179807.1 ENSMUST00000179807.2 uc292kbn.1 uc292kbn.2 uc292kbn.1 uc292kbn.2 
ENSMUST00000179812.3 Gm22447 ENSMUST00000179812.3 Gm22447 (from geneSymbol) ENSMUST00000179812.1 ENSMUST00000179812.2 uc291yqb.1 uc291yqb.2 uc291yqb.1 uc291yqb.2 
ENSMUST00000179814.3 Scgb2a2 ENSMUST00000179814.3 secretoglobin, family 2A, member 2 (from RefSeq NM_001378410.1) ENSMUST00000179814.1 ENSMUST00000179814.2 J3KMP9 J3KMP9_MOUSE NM_001378410 Scgb2a2 uc289qvj.1 uc289qvj.2 Secreted molecular_function extracellular space androgen receptor signaling pathway uc289qvj.1 uc289qvj.2 
ENSMUST00000179823.3 Gm23966 ENSMUST00000179823.3 Gm23966 (from geneSymbol) ENSMUST00000179823.1 ENSMUST00000179823.2 uc287ije.1 uc287ije.2 uc287ije.1 uc287ije.2 
ENSMUST00000179829.3 Gm20821 ENSMUST00000179829.3 Belongs to the SPIN/STSY family. (from UniProt J3QPJ2) ENSMUST00000179829.1 ENSMUST00000179829.2 Gm20821 J3QPJ2 J3QPJ2_MOUSE uc292sep.1 uc292sep.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sep.1 uc292sep.2 
ENSMUST00000179833.2 Gm15099 ENSMUST00000179833.2 Gm15099 (from geneSymbol) ENSMUST00000179833.1 uc292rau.1 uc292rau.2 uc292rau.1 uc292rau.2 
ENSMUST00000179848.2 Esp18 ENSMUST00000179848.2 exocrine gland secreted peptide 18 (from RefSeq NM_001244763.1) A8R0V1 A8R0V1_MOUSE ENSMUST00000179848.1 Esp18 Gm20579 NM_001244763 uc029tht.1 uc029tht.2 pheromone activity extracellular space biological_process uc029tht.1 uc029tht.2 
ENSMUST00000179851.3 Cdc5lrt6 ENSMUST00000179851.3 Belongs to the CEF1 family. (from UniProt A0A1W2P6Q8) A0A1W2P6Q8 A0A1W2P6Q8_MOUSE Cdc5lrt5 Cdc5lrt6 ENSMUST00000179851.1 ENSMUST00000179851.2 Gm9040 Gm9044 LF224720 uc029rid.1 uc029rid.2 uc029rid.3 Belongs to the CEF1 family. DNA binding uc029rid.1 uc029rid.2 uc029rid.3 
ENSMUST00000179857.3 Tomm20 ENSMUST00000179857.3 translocase of outer mitochondrial membrane 20 (from RefSeq NM_024214.2) ENSMUST00000179857.1 ENSMUST00000179857.2 NM_024214 Q9DCC8 TOM20_MOUSE uc009nza.1 uc009nza.2 uc009nza.3 uc009nza.4 Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOM22. Interacts with APEX1 (By similarity). Interacts with TBC1D21 (PubMed:32976492). Mitochondrion outer membrane ; Single-pass membrane protein Expressed in brain, kidney, stomach, colon, jejunum, ileum, testis, ovary and oviduct (at protein level) (PubMed:19492028). In the brain, expressed in neural cells of the cerebrum and cerebellum (at protein level) (PubMed:19492028). In the kidney, expressed in the proximal to distal tubule in the cortex and the outer and inner zones of the medulla (at protein level) (PubMed:19492028). In the stomach, expressed in the basal layer of stratified squamous epithelia in the forestomach and in the gastric pit and fundic gland of the glandular stomach (at protein level) (PubMed:19492028). Expressed in epithelial cells of the jejunum, ileum, and colon (at protein level) (PubMed:19492028). In the testis, expressed by spermatocytes and spermatogonia (at protein level) (PubMed:19492028). In the ovaries, expressed by follicular epithelial cells and corpus luteum cells (at protein level) (PubMed:19492028). In the oviduct, expressed in the epithelia of the isthmus and the ciliated cells of the ampulla (at protein level) (PubMed:19492028). Expressed in the sperm midpiece (at protein level) (PubMed:19492028, PubMed:32976492). Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. Belongs to the Tom20 family. mitochondrion mitochondrial envelope mitochondrial outer membrane mitochondrial outer membrane translocase complex protein targeting protein targeting to mitochondrion intracellular protein transport response to muscle activity protein transport P-P-bond-hydrolysis-driven protein transmembrane transporter activity membrane integral component of membrane tRNA import into mitochondrion protein import into mitochondrial matrix mitochondrion targeting sequence binding integral component of mitochondrial outer membrane ER-mitochondrion membrane contact site unfolded protein binding mitochondrial outer membrane translocase complex assembly response to 3,3',5-triiodo-L-thyronine protein transmembrane transporter activity uc009nza.1 uc009nza.2 uc009nza.3 uc009nza.4 
ENSMUST00000179859.2 H2al1g ENSMUST00000179859.2 H2A histone family member L1G (from RefSeq NM_001242952.1) ENSMUST00000179859.1 H2AL1_MOUSE H2al1a H2al1c H2al1d H2al1f H2al1g H2al1h H2al1i NM_001242952 Q5M8Q2 uc029xig.1 uc029xig.2 Atypical histone H2A which can replace conventional H2A in some nucleosomes and may play a role during spermatogenesis. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes, replacing one or more H2A molecules. Interacts with H2BC1/TH2B; preferentially dimerizes with H2BC1/TH2B to form nucleosomes (PubMed:17261847). Nucleus Chromosome Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847). Testis-specific. Strongly enriched in step 12-16 spermatids and accumulate during late spermiogenesis, in condensing spermatids (PubMed:17261847). Remains present in mature spermatozoa isolated from epididymis (PubMed:17261847). Rapidly disappears from the paternal pericentric heterochromatin regions after sperm-egg fusion (PubMed:18703863). In contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding protein binding nucleus chromosome pericentric heterochromatin DNA packaging chromatin organization spermatogenesis cell differentiation DNA packaging complex protein heterodimerization activity uc029xig.1 uc029xig.2 
ENSMUST00000179865.8 Canx ENSMUST00000179865.8 calnexin, transcript variant 1 (from RefSeq NM_007597.3) Canx ENSMUST00000179865.1 ENSMUST00000179865.2 ENSMUST00000179865.3 ENSMUST00000179865.4 ENSMUST00000179865.5 ENSMUST00000179865.6 ENSMUST00000179865.7 NM_007597 Q5SUC3 Q5SUC3_MOUSE uc007isg.1 uc007isg.2 uc007isg.3 uc007isg.4 Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. Endoplasmic reticulum membrane ; Single-pass type I membrane protein Melanosome Membrane ; Single-pass type I membrane protein Belongs to the calreticulin family. calcium ion binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane smooth endoplasmic reticulum rough endoplasmic reticulum ribosome protein folding aging membrane integral component of membrane axon dendrite cytoplasm macromolecular complex apolipoprotein binding ionotropic glutamate receptor binding neuronal cell body dendritic spine ER-mitochondrion membrane contact site unfolded protein binding glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic active zone membrane uc007isg.1 uc007isg.2 uc007isg.3 uc007isg.4 
ENSMUST00000179869.3 Hmgcs1 ENSMUST00000179869.3 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1, transcript variant 1 (from RefSeq NM_145942.5) ENSMUST00000179869.1 ENSMUST00000179869.2 HMCS1_MOUSE Hmgcs1 NM_145942 Q3UXI4 Q8JZK9 uc007rzw.1 uc007rzw.2 uc007rzw.3 uc007rzw.4 Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. Reaction=acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3- methylglutaryl-CoA + CoA + H(+); Xref=Rhea:RHEA:10188, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43074, ChEBI:CHEBI:57286, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.3.10; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10189; Evidence=; Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3. Homodimer. Cytoplasm Belongs to the thiolase-like superfamily. HMG-CoA synthase family. liver development catalytic activity hydroxymethylglutaryl-CoA synthase activity cytoplasm cytosol acetyl-CoA metabolic process lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process brain development drug binding steroid metabolic process cholesterol metabolic process isoprenoid biosynthetic process male gonad development response to low light intensity stimulus response to hormone response to organic substance farnesyl diphosphate biosynthetic process, mevalonate pathway response to organic cyclic compound response to purine-containing compound sterol biosynthetic process transferase activity isomerase activity response to vitamin E response to gonadotropin response to drug protein homodimerization activity organic acid binding response to tellurium ion response to cholesterol cellular response to follicle-stimulating hormone stimulus cellular response to cholesterol cellular response to low-density lipoprotein particle stimulus cellular response to organic cyclic compound uc007rzw.1 uc007rzw.2 uc007rzw.3 uc007rzw.4 
ENSMUST00000179874.2 Gm4836 ENSMUST00000179874.2 predicted gene 4836 (from RefSeq NM_009529.3) ENSMUST00000179874.1 Gm10058 Gm10096 Gm10147 Gm10230 Gm10486 Gm10487 Gm14632 Gm14819 Gm4836 NM_009529 Q62478 Q62478_MOUSE XMR uc009svw.1 uc009svw.2 uc009svw.3 uc009svw.4 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function nucleus spermatogenesis spermatid development meiotic cell cycle uc009svw.1 uc009svw.2 uc009svw.3 uc009svw.4 
ENSMUST00000179883.2 Ighd3-2 ENSMUST00000179883.2 Ighd3-2 (from geneSymbol) ENSMUST00000179883.1 uc288jsf.1 uc288jsf.2 uc288jsf.1 uc288jsf.2 
ENSMUST00000179890.2 ENSMUSG00000096100 ENSMUST00000179890.2 ENSMUSG00000096100 (from geneSymbol) ENSMUST00000179890.1 uc289spe.1 uc289spe.2 uc289spe.1 uc289spe.2 
ENSMUST00000179907.2 G430049J08Rik ENSMUST00000179907.2 G430049J08Rik (from geneSymbol) AK166742 ENSMUST00000179907.1 uc289npz.1 uc289npz.2 uc289npz.1 uc289npz.2 
ENSMUST00000179915.4 Rhox4a2 ENSMUST00000179915.4 Nucleus (from UniProt Q9D3I8) AJ972665 ENSMUST00000179915.1 ENSMUST00000179915.2 ENSMUST00000179915.3 Q9D3I8 Q9D3I8_MOUSE Rhox4.1 Rhox4a Rhox4a2 uc029xjk.1 uc029xjk.2 uc029xjk.3 uc029xjk.4 Nucleus molecular_function DNA binding cellular_component nucleus biological_process uc029xjk.1 uc029xjk.2 uc029xjk.3 uc029xjk.4 
ENSMUST00000179917.2 Lce1k ENSMUST00000179917.2 late cornified envelope 1K (from RefSeq NM_001254760.1) ENSMUST00000179917.1 J3QP15 J3QP15_MOUSE Lce1k NM_001254760 uc029unj.1 uc029unj.2 Belongs to the LCE family. epidermis development uc029unj.1 uc029unj.2 
ENSMUST00000179923.3 Gm55722 ENSMUST00000179923.3 Gm55722 (from geneSymbol) DM004912 ENSMUST00000179923.1 ENSMUST00000179923.2 uc012bpt.1 uc012bpt.2 uc012bpt.1 uc012bpt.2 
ENSMUST00000179933.3 Gm25235 ENSMUST00000179933.3 Gm25235 (from geneSymbol) ENSMUST00000179933.1 ENSMUST00000179933.2 LF192995 uc287nqf.1 uc287nqf.2 uc287nqf.1 uc287nqf.2 
ENSMUST00000179944.2 Sgo2b ENSMUST00000179944.2 shugoshin 2B (from RefSeq NM_001195687.1) ENSMUST00000179944.1 J3QMK1 J3QMK1_MOUSE NM_001195687 Sgo2b Sgol2b uc012geg.1 uc012geg.2 Chromosome, centromere Belongs to the shugoshin family. chromosome, centromeric region nucleoplasm nuclear body meiotic sister chromatid cohesion, centromeric uc012geg.1 uc012geg.2 
ENSMUST00000179945.3 Csmd2os ENSMUST00000179945.3 Csmd2os (from geneSymbol) AK015502 ENSMUST00000179945.1 ENSMUST00000179945.2 uc290pzb.1 uc290pzb.2 uc290pzb.1 uc290pzb.2 
ENSMUST00000179949.3 Gm20823 ENSMUST00000179949.3 predicted gene, 20823 (from RefSeq NM_001160143.1) ENSMUST00000179949.1 ENSMUST00000179949.2 Gm20738 Gm20823 Gm20924 Gm21249 LOC382133 NM_001160143 Q810R8 Q810R8_MOUSE uc009vgt.1 uc009vgt.2 uc009vgt.3 uc009vgt.4 uc009vgt.5 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc009vgt.1 uc009vgt.2 uc009vgt.3 uc009vgt.4 uc009vgt.5 
ENSMUST00000179960.8 Tac2 ENSMUST00000179960.8 tachykinin 2, transcript variant 2 (from RefSeq NM_001199971.1) ENSMUST00000179960.1 ENSMUST00000179960.2 ENSMUST00000179960.3 ENSMUST00000179960.4 ENSMUST00000179960.5 ENSMUST00000179960.6 ENSMUST00000179960.7 NM_001199971 Nknb P55099 Q9QXS9 TKNK_MOUSE Tac3 uc007hkj.1 uc007hkj.2 uc007hkj.3 uc007hkj.4 This gene encodes a member of the tachykinin family of signaling peptides that is widely expressed in the central nervous system and plays a role in diverse processes such as water homeostasis, pulmonary inflammation, cognition, fear memory consolidation and preeclampsia. The encoded protein is enzymatically processed to generate the mature neuropeptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]. Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity). Secreted. Belongs to the tachykinin family. extracellular region extracellular space tachykinin receptor signaling pathway neuropeptide signaling pathway neuromedin K receptor binding substance K receptor binding positive regulation of blood pressure positive regulation of flagellated sperm motility uc007hkj.1 uc007hkj.2 uc007hkj.3 uc007hkj.4 
ENSMUST00000179971.8 Rfpl4 ENSMUST00000179971.8 ret finger protein-like 4, transcript variant 2 (from RefSeq NM_001145013.1) ENSMUST00000179971.1 ENSMUST00000179971.2 ENSMUST00000179971.3 ENSMUST00000179971.4 ENSMUST00000179971.5 ENSMUST00000179971.6 ENSMUST00000179971.7 NM_001145013 Q6IS67 Q8VH31 RFPLA_MOUSE Rfpl4a uc009fab.1 uc009fab.2 uc009fab.3 Interacts with PSMB1, UBE2A and CCNB1. Cytoplasm Nucleus Expressed in the ovaries and oocytes (at protein level) (PubMed:12525704, PubMed:11850190). Expression restricted to gonads. In testis, present at later stages of spermatogeneis and abundant in elongating spermatids. Expressed in growing oocytes and early embryos. protein binding nucleus cytoplasm metal ion binding uc009fab.1 uc009fab.2 uc009fab.3 
ENSMUST00000179972.2 ENSMUSG00000095570 ENSMUST00000179972.2 ENSMUSG00000095570 (from geneSymbol) ENSMUST00000179972.1 uc291cez.1 uc291cez.2 uc291cez.1 uc291cez.2 
ENSMUST00000179976.3 Sh2d1b1 ENSMUST00000179976.3 SH2 domain containing 1B1, transcript variant 2 (from RefSeq NR_153837.1) ENSMUST00000179976.1 ENSMUST00000179976.2 NR_153837 Q149T1 Q149T1_MOUSE Sh2d1b1 uc007dmc.1 uc007dmc.2 uc007dmc.3 uc007dmc.1 uc007dmc.2 uc007dmc.3 
ENSMUST00000179991.3 Btbd35f2 ENSMUST00000179991.3 BTB domain containing 35, family member 2 (from RefSeq NM_001168334.1) Btbd35f2 ENSMUST00000179991.1 ENSMUST00000179991.2 Gm2799 J3QMS5 J3QMS5_MOUSE NM_001168334 uc057mbh.1 uc057mbh.2 uc057mbh.3 molecular_function cellular_component biological_process uc057mbh.1 uc057mbh.2 uc057mbh.3 
ENSMUST00000179996.3 Zfp994 ENSMUST00000179996.3 zinc finger protein 994, transcript variant 9 (from RefSeq NM_001418936.1) ENSMUST00000179996.1 ENSMUST00000179996.2 J3QM38 J3QM38_MOUSE NM_001418936 Zfp994 uc029tav.1 uc029tav.2 uc029tav.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc029tav.1 uc029tav.2 uc029tav.3 
ENSMUST00000179997.2 Trav5n-4 ENSMUST00000179997.2 Trav5n-4 (from geneSymbol) ENSMUST00000179997.1 M38681 Q5R1F6 Q5R1F6_MOUSE TRAV5D-4 Trav5d-4 Trav5n-4 uc007trr.1 uc007trr.2 uc007trr.3 uc007trr.4 uc007trr.5 uc007trr.1 uc007trr.2 uc007trr.3 uc007trr.4 uc007trr.5 
ENSMUST00000180001.2 Ighd2-8 ENSMUST00000180001.2 Ighd2-8 (from geneSymbol) ENSMUST00000180001.1 uc288jsi.1 uc288jsi.2 uc288jsi.1 uc288jsi.2 
ENSMUST00000180013.3 Ighv2-9-1 ENSMUST00000180013.3 Ighv2-9-1 (from geneSymbol) A0A075B697 A0A075B697_MOUSE BC011181 ENSMUST00000180013.1 ENSMUST00000180013.2 Ighv2-9-1 uc288jug.1 uc288jug.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jug.1 uc288jug.2 
ENSMUST00000180036.8 Oaz1 ENSMUST00000180036.8 ornithine decarboxylase antizyme 1, transcript variant 1 (from RefSeq NM_008753.4) ENSMUST00000180036.1 ENSMUST00000180036.2 ENSMUST00000180036.3 ENSMUST00000180036.4 ENSMUST00000180036.5 ENSMUST00000180036.6 ENSMUST00000180036.7 NM_008753 O08610 OAZ1_MOUSE Oaz P54369 uc033frg.1 uc033frg.2 uc033frg.3 The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]. Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin- independent proteolytic destruction by the 26S proteasome (PubMed:16916800, PubMed:18508777). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (By similarity). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:18062773). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338). Interacts with ODC1 and thereby sterically blocks ODC homodimerization (By similarity). Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome (By similarity). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:16916800, PubMed:18062773, PubMed:24967154). Interacts with FAM171A1 (By similarity). Event=Ribosomal frameshifting; Named isoforms=1; Comment=A ribosomal frameshift occurs between the codons for Ser-68 and Asp-69. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.; Name=1; IsoId=P54369-1; Sequence=Displayed; Belongs to the ODC antizyme family. protein binding nucleus cytoplasm cytosol polyamine metabolic process polyamine biosynthetic process ornithine decarboxylase inhibitor activity enzyme binding negative regulation of catalytic activity positive regulation of protein catabolic process protein heterodimerization activity positive regulation of intracellular protein transport negative regulation of polyamine transmembrane transport uc033frg.1 uc033frg.2 uc033frg.3 
ENSMUST00000180037.8 Birc6 ENSMUST00000180037.8 baculoviral IAP repeat-containing 6, transcript variant 1 (from RefSeq NM_007566.3) BIRC6_MOUSE E9PYU6 ENSMUST00000180037.1 ENSMUST00000180037.2 ENSMUST00000180037.3 ENSMUST00000180037.4 ENSMUST00000180037.5 ENSMUST00000180037.6 ENSMUST00000180037.7 Kiaa1289 NM_007566 O88738 Q69ZM5 Q8BNX0 Q8BR72 Q8BRV7 Q8C737 uc033hfd.1 uc033hfd.2 Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its targets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9. Homodimer. Binds the activated, processed forms of CASP3, CASP6 and CASP7. Interacts with RNF41, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8 (By similarity). Interacts with CASP9, DIABLO/SMAC and HTRA2. Golgi apparatus, trans-Golgi network membrane Endosome Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody, Midbody ring Note=Exhibits cell cycle- dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body. In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O88738-1; Sequence=Displayed; Name=2; IsoId=O88738-2; Sequence=VSP_042537; Name=3; IsoId=O88738-3; Sequence=VSP_042536, VSP_042537; Widely expressed. Highly expressed in the brain and kidney. The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9. Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY (By similarity). Mice exhibit perinatal lethality and growth deficiencies, which are linked to a defect in proper placental development. In the C-terminal section; belongs to the ubiquitin- conjugating enzyme family. Sequence=BAC32373.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC37801.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=CAA76720.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; spindle pole placenta development ubiquitin-protein transferase activity cysteine-type endopeptidase inhibitor activity protein binding nucleus cytoplasm endosome Golgi apparatus trans-Golgi network microtubule organizing center cytoskeleton ubiquitin-dependent protein catabolic process apoptotic process cell cycle positive regulation of cell proliferation negative regulation of peptidase activity negative regulation of endopeptidase activity membrane protein ubiquitination transferase activity peptidase inhibitor activity midbody regulation of cytokinesis regulation of cell proliferation negative regulation of apoptotic process cell division labyrinthine layer development spongiotrophoblast layer development ubiquitin conjugating enzyme activity Flemming body negative regulation of extrinsic apoptotic signaling pathway uc033hfd.1 uc033hfd.2 
ENSMUST00000180038.8 Ccdc179 ENSMUST00000180038.8 coiled-coil domain containing 179 (from RefSeq NM_001195601.1) CC179_MOUSE ENSMUST00000180038.1 ENSMUST00000180038.2 ENSMUST00000180038.3 ENSMUST00000180038.4 ENSMUST00000180038.5 ENSMUST00000180038.6 ENSMUST00000180038.7 J3QM76 NM_001195601 uc009hco.1 uc009hco.2 uc009hco.3 uc009hco.4 molecular_function cellular_component biological_process uc009hco.1 uc009hco.2 uc009hco.3 uc009hco.4 
ENSMUST00000180041.9 Stard9 ENSMUST00000180041.9 StAR related lipid transfer domain containing 9 (from RefSeq NM_001370940.1) ENSMUST00000180041.1 ENSMUST00000180041.2 ENSMUST00000180041.3 ENSMUST00000180041.4 ENSMUST00000180041.5 ENSMUST00000180041.6 ENSMUST00000180041.7 ENSMUST00000180041.8 Kiaa1300 Kif16a NM_001370940 O35058 Q80TF6 Q8C121 Q8CFL0 STAR9_MOUSE uc012cch.1 uc012cch.2 uc012cch.3 Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM) (By similarity). Interacts with ATAD3A. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Nucleus Note=Localizes throughout the cytoplasm and nucleus during interphase. Localizes to the daughter centriole during mitosis. Disappears in cytokinesis (By similarity). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding microtubule motor activity ATP binding nucleus cytoplasm centriole cytoskeleton kinesin complex microtubule microtubule-based movement microtubule binding lipid binding ATP-dependent microtubule motor activity, plus-end-directed ATPase activity spindle assembly uc012cch.1 uc012cch.2 uc012cch.3 
ENSMUST00000180046.8 Usp34 ENSMUST00000180046.8 ubiquitin specific peptidase 34 (from RefSeq NM_001190401.2) A2AF26 A2AF27 A2AF77 ENSMUST00000180046.1 ENSMUST00000180046.2 ENSMUST00000180046.3 ENSMUST00000180046.4 ENSMUST00000180046.5 ENSMUST00000180046.6 ENSMUST00000180046.7 Kiaa0570 Murr2 NM_001190401 Q3UF93 Q3UPN0 Q6P563 Q6ZQ93 Q7TMJ6 Q8CCH0 UBP34_MOUSE uc029rkw.1 uc029rkw.2 Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with AXIN1 and AXIN2. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6ZQ93-1; Sequence=Displayed; Name=2; IsoId=Q6ZQ93-2; Sequence=VSP_035641, VSP_035642; Name=3; IsoId=Q6ZQ93-3; Sequence=VSP_035641, VSP_035642, VSP_020465; Name=4; IsoId=Q6ZQ93-4; Sequence=VSP_035641, VSP_035642, VSP_020464; Belongs to the peptidase C19 family. Sequence=AAH55938.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=CAM20294.1; Type=Erroneous initiation; Evidence=; cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity cytoplasm proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity Wnt signaling pathway protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity protein K48-linked deubiquitination positive regulation of canonical Wnt signaling pathway uc029rkw.1 uc029rkw.2 
ENSMUST00000180050.3 Gm25065 ENSMUST00000180050.3 Gm25065 (from geneSymbol) ENSMUST00000180050.1 ENSMUST00000180050.2 uc291ire.1 uc291ire.2 uc291ire.1 uc291ire.2 
ENSMUST00000180052.8 4930544D05Rik ENSMUST00000180052.8 4930544D05Rik (from geneSymbol) 4930544D05Rik AK019734 ENSMUST00000180052.1 ENSMUST00000180052.2 ENSMUST00000180052.3 ENSMUST00000180052.4 ENSMUST00000180052.5 ENSMUST00000180052.6 ENSMUST00000180052.7 J3QK56 J3QK56_MOUSE uc287zrk.1 uc287zrk.2 molecular_function cellular_component biological_process uc287zrk.1 uc287zrk.2 
ENSMUST00000180053.3 Eif1ad14 ENSMUST00000180053.3 Belongs to the eIF-1A family. (from UniProt J3QP87) ENSMUST00000180053.1 ENSMUST00000180053.2 Eif1ad14 J3QP87 J3QP87_MOUSE uc288iet.1 uc288iet.2 uc288iet.3 Belongs to the eIF-1A family. RNA binding translation initiation factor activity translation translational initiation uc288iet.1 uc288iet.2 uc288iet.3 
ENSMUST00000180066.9 ENSMUSG00000121890 ENSMUST00000180066.9 ENSMUSG00000121890 (from geneSymbol) ENSMUST00000180066.1 ENSMUST00000180066.2 ENSMUST00000180066.3 ENSMUST00000180066.4 ENSMUST00000180066.5 ENSMUST00000180066.6 ENSMUST00000180066.7 ENSMUST00000180066.8 uc288pkb.1 uc288pkb.2 uc288pkb.1 uc288pkb.2 
ENSMUST00000180077.8 Cebpzos ENSMUST00000180077.8 CCAAT/enhancer binding protein zeta, opposite strand, transcript variant 2 (from RefSeq NM_001177402.1) CEBOS_MOUSE Cebpzos ENSMUST00000180077.1 ENSMUST00000180077.2 ENSMUST00000180077.3 ENSMUST00000180077.4 ENSMUST00000180077.5 ENSMUST00000180077.6 ENSMUST00000180077.7 NM_001177402 Q8BTE5 uc008dpj.1 uc008dpj.2 uc008dpj.3 uc008dpj.4 uc008dpj.5 Mitochondrion membrane ; Single-pass membrane protein molecular_function cellular_component mitochondrion biological_process membrane integral component of membrane mitochondrial membrane uc008dpj.1 uc008dpj.2 uc008dpj.3 uc008dpj.4 uc008dpj.5 
ENSMUST00000180078.3 Gm23186 ENSMUST00000180078.3 Gm23186 (from geneSymbol) ENSMUST00000180078.1 ENSMUST00000180078.2 uc289grg.1 uc289grg.2 uc289grg.1 uc289grg.2 
ENSMUST00000180086.3 H1f0 ENSMUST00000180086.3 H1.0 linker histone (from RefSeq NM_008197.3) ENSMUST00000180086.1 ENSMUST00000180086.2 H1-0 H10_MOUSE H1fv NM_008197 P10922 Q3UKC0 uc007wsd.1 uc007wsd.2 uc007wsd.3 uc007wsd.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 25645921 ##RefSeq-Attributes-END## Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division. Nucleus. Chromosome. ADP-ribosylated on Ser-104 in response to DNA damage. Belongs to the histone H1/H5 family. negative regulation of transcription from RNA polymerase II promoter nucleosome nuclear chromatin DNA binding AT DNA binding double-stranded DNA binding nucleus chromosome nuclear euchromatin Golgi apparatus nucleosome assembly chromatin silencing regulation of transcription, DNA-templated actin cytoskeleton nucleosome positioning nuclear body transcriptional repressor complex chromosome condensation chromatin DNA binding nucleosomal DNA binding negative regulation of chromatin silencing negative regulation of DNA recombination positive regulation of transcription regulatory region DNA binding nucleolus uc007wsd.1 uc007wsd.2 uc007wsd.3 uc007wsd.4 
ENSMUST00000180088.2 Tbc1d10a ENSMUST00000180088.2 TBC1 domain family, member 10a (from RefSeq NM_134023.2) ENSMUST00000180088.1 Epi64 NM_134023 P58802 TB10A_MOUSE Tbc1d10 uc287whc.1 uc287whc.2 Acts as a GTPase-activating protein for RAB27A. Binds to the first PDZ domain of NHERF1 and NHERF2. Cell projection, microvillus Note=Localizes to the microvilli-rich region of the syncytiotrophoblast. Expressed in most tissues, except for skeletal muscle. The arginine and glutamine fingers are critical for the GTPase- activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site. guanyl-nucleotide exchange factor activity GTPase activator activity cytosol plasma membrane microvillus intracellular protein transport Rab GTPase binding PDZ domain binding retrograde transport, endosome to Golgi cell projection positive regulation of proteolysis activation of GTPase activity activation of cysteine-type endopeptidase activity uc287whc.1 uc287whc.2 
ENSMUST00000180092.2 Msantd5f4 ENSMUST00000180092.2 Myb/SANT DNA binding domain containing 5 family member 4 (from RefSeq NM_001277531.1) ENSMUST00000180092.1 Gm11236 J3QMS7 J3QMS7_MOUSE Msantd5f4 NM_001277531 uc290nhr.1 uc290nhr.2 This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is inferred from alignment of paralogous transcripts. [provided by RefSeq, Apr 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignment of paralogous transcripts. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## molecular_function cellular_component biological_process uc290nhr.1 uc290nhr.2 
ENSMUST00000180095.4 Mlf2 ENSMUST00000180095.4 myeloid leukemia factor 2, transcript variant 1 (from RefSeq NM_145385.2) ENSMUST00000180095.1 ENSMUST00000180095.2 ENSMUST00000180095.3 MLF2_MOUSE NM_145385 Q99KX1 uc009dsp.1 uc009dsp.2 uc009dsp.3 uc009dsp.4 Cytoplasm Nucleus Belongs to the MLF family. DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated uc009dsp.1 uc009dsp.2 uc009dsp.3 uc009dsp.4 
ENSMUST00000180098.3 Gm26139 ENSMUST00000180098.3 Gm26139 (from geneSymbol) ENSMUST00000180098.1 ENSMUST00000180098.2 uc288wcw.1 uc288wcw.2 uc288wcw.1 uc288wcw.2 
ENSMUST00000180100.2 Gm10097 ENSMUST00000180100.2 Gm10097 (from geneSymbol) ENSMUST00000180100.1 uc287phn.1 uc287phn.2 uc287phn.1 uc287phn.2 
ENSMUST00000180108.3 Gm22446 ENSMUST00000180108.3 Gm22446 (from geneSymbol) ENSMUST00000180108.1 ENSMUST00000180108.2 uc287ozx.1 uc287ozx.2 uc287ozx.1 uc287ozx.2 
ENSMUST00000180119.2 ENSMUSG00000094728 ENSMUST00000180119.2 ENSMUSG00000094728 (from geneSymbol) ENSMUST00000180119.1 uc289spm.1 uc289spm.2 uc289spm.1 uc289spm.2 
ENSMUST00000180129.3 Gm23805 ENSMUST00000180129.3 Gm23805 (from geneSymbol) DQ558729 ENSMUST00000180129.1 ENSMUST00000180129.2 uc287oea.1 uc287oea.2 uc287oea.1 uc287oea.2 
ENSMUST00000180137.3 Gm25099 ENSMUST00000180137.3 Gm25099 (from geneSymbol) DQ561416 ENSMUST00000180137.1 ENSMUST00000180137.2 uc290pdc.1 uc290pdc.2 uc290pdc.1 uc290pdc.2 
ENSMUST00000180139.3 Spata31d1e ENSMUST00000180139.3 Membrane ; Single- pass membrane protein (from UniProt J3QMS2) 1700014D04Rik AK077007 ENSMUST00000180139.1 ENSMUST00000180139.2 J3QMS2 J3QMS2_MOUSE uc288nkf.1 uc288nkf.2 Membrane ; Single- pass membrane protein Belongs to the SPATA31 family. molecular_function cellular_component biological_process uc288nkf.1 uc288nkf.2 
ENSMUST00000180140.8 Hcfc1r1 ENSMUST00000180140.8 host cell factor C1 regulator 1 (XPO1-dependent), transcript variant 2 (from RefSeq NM_001414380.1) ENSMUST00000180140.1 ENSMUST00000180140.2 ENSMUST00000180140.3 ENSMUST00000180140.4 ENSMUST00000180140.5 ENSMUST00000180140.6 ENSMUST00000180140.7 HPIP_MOUSE Hpip NM_001414380 Q9CYQ5 uc289htv.1 uc289htv.2 Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus (By similarity). Interacts with HCFC1. Cytoplasm Nucleus Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. molecular_function nucleus nucleoplasm cytoplasm biological_process uc289htv.1 uc289htv.2 
ENSMUST00000180150.8 Gm16405 ENSMUST00000180150.8 predicted gene 16405 (from RefSeq NM_001166646.1) A6X8J1 A6X8J1_MOUSE ENSMUST00000180150.1 ENSMUST00000180150.2 ENSMUST00000180150.3 ENSMUST00000180150.4 ENSMUST00000180150.5 ENSMUST00000180150.6 ENSMUST00000180150.7 Gm14594 Gm16405 Gm16430 Gm7958 NM_001166646 uc009tfp.1 uc009tfp.2 uc009tfp.3 synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc009tfp.1 uc009tfp.2 uc009tfp.3 
ENSMUST00000180151.3 Gm5849 ENSMUST00000180151.3 Cytoplasm Secreted (from UniProt J3QPE5) ENSMUST00000180151.1 ENSMUST00000180151.2 Gm5849 J3QPE5 J3QPE5_MOUSE uc290hdw.1 uc290hdw.2 uc290hdw.3 Cytoplasm Secreted molecular_function calcium ion binding cellular_component microtubule binding biological_process zinc ion binding Toll-like receptor 4 binding innate immune response arachidonic acid binding regulation of inflammatory response RAGE receptor binding uc290hdw.1 uc290hdw.2 uc290hdw.3 
ENSMUST00000180154.9 Plscr2 ENSMUST00000180154.9 May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. (from UniProt Q9DCW2) AK002410 ENSMUST00000180154.1 ENSMUST00000180154.2 ENSMUST00000180154.3 ENSMUST00000180154.4 ENSMUST00000180154.5 ENSMUST00000180154.6 ENSMUST00000180154.7 ENSMUST00000180154.8 O70233 PLS2_MOUSE Q921P6 Q9DCW2 uc292jqj.1 uc292jqj.2 uc292jqj.3 May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Membrane ; Single-pass type II membrane protein Expressed in erythrocyte membranes, blood platelets, blood leukocytes, T- and B-lymphocytes, vascular endothelium, spleen, thymus, prostate, testis, uterus, intestine and colon. The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity. Belongs to the phospholipid scramblase family. protein binding nucleus cytoplasm plasma membrane membrane integral component of membrane phospholipid scrambling SH3 domain binding phospholipid scramblase activity metal ion binding phosphatidylserine exposure on apoptotic cell surface cellular response to lipopolysaccharide uc292jqj.1 uc292jqj.2 uc292jqj.3 
ENSMUST00000180159.8 Polr2k ENSMUST00000180159.8 polymerase (RNA) II (DNA directed) polypeptide K, transcript variant 2 (from RefSeq NM_023127.3) ENSMUST00000180159.1 ENSMUST00000180159.2 ENSMUST00000180159.3 ENSMUST00000180159.4 ENSMUST00000180159.5 ENSMUST00000180159.6 ENSMUST00000180159.7 Mt1a NM_023127 Q63871 RPAB4_MOUSE uc007vml.1 uc007vml.2 uc007vml.3 uc007vml.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively (By similarity). The transcriptionally active Pol III complex consists of a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4- POLR3E/RPC5 heterodimer involved in both transcription initiation and termination (By similarity). Nucleus Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. Sequence=AAB27565.2; Type=Erroneous initiation; Evidence=; DNA binding DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm DNA-directed RNA polymerase II, core complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase I complex transcription, DNA-templated transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter transcription from RNA polymerase III promoter zinc ion binding metal ion binding RNA polymerase I activity RNA polymerase II activity RNA polymerase III activity uc007vml.1 uc007vml.2 uc007vml.3 uc007vml.4 
ENSMUST00000180161.2 Krtap10-25 ENSMUST00000180161.2 Krtap10-25 (from geneSymbol) ENSMUST00000180161.1 Gm7137 J3QMW1 J3QMW1_MOUSE uc287smo.1 uc287smo.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc287smo.1 uc287smo.2 
ENSMUST00000180165.3 Or2av9 ENSMUST00000180165.3 olfactory receptor family 2 subfamily AV member 9 (from RefSeq NM_001011770.2) ENSMUST00000180165.1 ENSMUST00000180165.2 NM_001011770 Olfr332 Or2av9 Q5NC45 Q5NC45_MOUSE uc007jbp.1 uc007jbp.2 uc007jbp.3 uc007jbp.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB173271.1, CB174117.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007jbp.1 uc007jbp.2 uc007jbp.3 uc007jbp.4 
ENSMUST00000180168.2 Mplkipl1 ENSMUST00000180168.2 M-phase specific PLK1 intereacting protein like 1 (from RefSeq NM_001177513.1) ENSMUST00000180168.1 J3QQ10 J3QQ10_MOUSE Mplkipl1 NM_001177513 uc012bol.1 uc012bol.2 molecular_function cellular_component biological_process uc012bol.1 uc012bol.2 
ENSMUST00000180180.8 Ecsit ENSMUST00000180180.8 ECSIT signalling integrator, transcript variant 4 (from RefSeq NM_001421174.1) A0A0R4J174 A0A0R4J174_MOUSE ENSMUST00000180180.1 ENSMUST00000180180.2 ENSMUST00000180180.3 ENSMUST00000180180.4 ENSMUST00000180180.5 ENSMUST00000180180.6 ENSMUST00000180180.7 Ecsit NM_001421174 uc009onu.1 uc009onu.2 uc009onu.3 uc009onu.4 As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. Cytoplasm Mitochondrion Nucleus Belongs to the ECSIT family. nucleus nucleoplasm cytoplasm mitochondrion cytosol oxidoreductase activity, acting on NAD(P)H regulation of oxidoreductase activity oxidation-reduction process uc009onu.1 uc009onu.2 uc009onu.3 uc009onu.4 
ENSMUST00000180187.2 Gm21971 ENSMUST00000180187.2 Gm21971 (from geneSymbol) AK018648 ENSMUST00000180187.1 uc288iue.1 uc288iue.2 uc288iue.1 uc288iue.2 
ENSMUST00000180195.8 Rad21l ENSMUST00000180195.8 RAD21-like (S. pombe) (from RefSeq NM_001276400.1) A2AU37 E5RTP6 ENSMUST00000180195.1 ENSMUST00000180195.2 ENSMUST00000180195.3 ENSMUST00000180195.4 ENSMUST00000180195.5 ENSMUST00000180195.6 ENSMUST00000180195.7 F6KST0 Gm14160 NM_001276400 RD21L_MOUSE Rad21l1 uc012cfy.1 uc012cfy.2 Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I. Not required for meiosis in females in young mice, while it is required later as mice age. Component of some meiotic cohesin complex composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21L which link them, and STAG3. Nucleus romosome te=In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements. Specifically expressed in male and female gonads (at protein level). Male mice are sterile due to defects in chromosome synapsis at prophase I, leading to an arrest at a zygotene- like stage leading to total azoospermia. Females are fertile but develop an age-dependent sterility. Belongs to the rad21 family. Sequence=CAM23443.1; Type=Erroneous gene model prediction; Evidence=; double-strand break repair via homologous recombination condensed nuclear chromosome lateral element chromatin binding nucleus chromosome double-strand break repair chromosome segregation sister chromatid cohesion synapsis synaptonemal complex assembly spermatogenesis cohesin complex fertilization meiotic cohesin complex nuclear meiotic cohesin complex meiotic cell cycle meiotic attachment of telomere to nuclear envelope seminiferous tubule development uc012cfy.1 uc012cfy.2 
ENSMUST00000180198.2 Pramel3c ENSMUST00000180198.2 Pramel3c (from geneSymbol) AK029697 ENSMUST00000180198.1 J3QP96 J3QP96_MOUSE Pramel3b Pramel3c uc029xmy.1 uc029xmy.2 uc029xmy.1 uc029xmy.2 
ENSMUST00000180201.2 Spata31f1b ENSMUST00000180201.2 spermatogenesis associated 31 subfamily F member 1B, transcript variant 1 (from RefSeq NM_001085530.1) 31F14_MOUSE A2APU8 C0HKD3 ENSMUST00000180201.1 Fam205a4 NM_001085530 Spata31f1-4 uc008snh.1 uc008snh.2 uc008snh.3 Membrane ; Single-pass membrane protein Belongs to the SPATA31 family. membrane integral component of membrane uc008snh.1 uc008snh.2 uc008snh.3 
ENSMUST00000180207.8 Gm10096 ENSMUST00000180207.8 predicted gene 10096 (from RefSeq NM_001102678.2) ENSMUST00000180207.1 ENSMUST00000180207.2 ENSMUST00000180207.3 ENSMUST00000180207.4 ENSMUST00000180207.5 ENSMUST00000180207.6 ENSMUST00000180207.7 Gm10058 Gm10096 Gm10147 Gm10230 Gm10486 Gm10487 Gm14632 Gm14819 Gm4836 NM_001102678 Q62478 Q62478_MOUSE XMR uc009swe.1 uc009swe.2 uc009swe.3 uc009swe.4 uc009swe.5 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function nucleus spermatogenesis spermatid development meiotic cell cycle uc009swe.1 uc009swe.2 uc009swe.3 uc009swe.4 uc009swe.5 
ENSMUST00000180208.2 ENSMUSG00000095475 ENSMUST00000180208.2 ENSMUSG00000095475 (from geneSymbol) ENSMUST00000180208.1 uc291cft.1 uc291cft.2 uc291cft.1 uc291cft.2 
ENSMUST00000180217.2 Zbtb5 ENSMUST00000180217.2 zinc finger and BTB domain containing 5, transcript variant 2 (from RefSeq NM_001163283.1) ENSMUST00000180217.1 Kiaa0354 NM_001163283 Q3TVR7 Q6GV09 Q7TQG0 Q8BIB5 ZBTB5_MOUSE uc012ddj.1 uc012ddj.2 uc012ddj.3 uc012ddj.4 May be involved in transcriptional regulation. Nucleus Sequence=BAC97934.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus cellular response to DNA damage stimulus metal ion binding uc012ddj.1 uc012ddj.2 uc012ddj.3 uc012ddj.4 
ENSMUST00000180239.2 Fsbp ENSMUST00000180239.2 fibrinogen silencer binding protein (from RefSeq NM_001256142.1) ENSMUST00000180239.1 FSBP_MOUSE NM_001256142 Q8BJX8 Q8BKE5 uc008rzt.1 uc008rzt.2 uc008rzt.3 uc008rzt.4 Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1. Interacts with APBA1 (via PDZ 1 and 2 domains). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BKE5-1; Sequence=Displayed; Name=2; IsoId=Q8BKE5-2; Sequence=VSP_010775; nucleus biological_process identical protein binding uc008rzt.1 uc008rzt.2 uc008rzt.3 uc008rzt.4 
ENSMUST00000180246.8 Ankef1 ENSMUST00000180246.8 Ankef1 (from geneSymbol) ANKE1_MOUSE Ankrd5 BC120825 ENSMUST00000180246.1 ENSMUST00000180246.2 ENSMUST00000180246.3 ENSMUST00000180246.4 ENSMUST00000180246.5 ENSMUST00000180246.6 ENSMUST00000180246.7 Q0VB20 Q9D2J7 uc290avj.1 uc290avj.2 molecular_function cellular_component biological_process uc290avj.1 uc290avj.2 
ENSMUST00000180248.8 Rbm4 ENSMUST00000180248.8 RNA binding motif protein 4, transcript variant 1 (from RefSeq NM_009032.3) ENSMUST00000180248.1 ENSMUST00000180248.2 ENSMUST00000180248.3 ENSMUST00000180248.4 ENSMUST00000180248.5 ENSMUST00000180248.6 ENSMUST00000180248.7 NM_009032 O08752 Q8BN66 Q8C7Q4 RBM4_MOUSE Rbm4a uc008gau.1 uc008gau.2 uc008gau.3 RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU- rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA- guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. Interacts with TNPO3; the interaction mediates nuclear import of the protein and is disrupted by nuclear Ran bound to GTP. Interacts with EIF4G1 and WT1. Interacts with EIF4A1; the interaction is modulated under stress-induced conditions. Interacts with AGO1. Interacts with AGO2; the interaction occurs under both cell proliferation and differentiation conditions and in an RNA- and phosphorylation-independent manner. Interacts with DDX5; the interaction occurs in an RNA-independent manner (By similarity). Nucleus Nucleus, nucleolus Nucleus speckle Cytoplasm Cytoplasmic granule Note=Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C7Q4-1; Sequence=Displayed; Name=2; IsoId=Q8C7Q4-2; Sequence=VSP_013417, VSP_013418; Expressed in the suprachiasmatic nucleus (SCN). Expressed in myocytes; expression gradually increases during muscle cell differentiation (at protein level). Expressed in the suprachiasmatic nucleus (SCN). Accumulates according to a circadian rhythm in the SCN. Phosphorylated. Phosphorylated in vitro on Ser-306 by SRPK1. Phosphorylation on Ser-306 is induced upon cell stress signaling, which alters its subcellular localization and may modulate its activity on IRES-mediated mRNA translation (By similarity). Phosphorylated. Phosphorylation on Ser-306 is induced upon cell muscle differentiation. [Isoform 2]: May be due to an intron retention. Sequence=AAC53171.1; Type=Frameshift; Evidence=; regulation of alternative mRNA splicing, via spliceosome cap-independent translational initiation IRES-dependent translational initiation nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding nucleus nucleoplasm nucleolus cytoplasm cytosol mRNA processing zinc ion binding RNA splicing regulation of gene expression cytoplasmic stress granule nuclear speck negative regulation of translation cell differentiation cyclin binding pancreas development gene silencing by RNA negative regulation of translation in response to stress circadian regulation of gene expression miRNA binding miRNA mediated inhibition of translation insulin secretion involved in cellular response to glucose stimulus enteroendocrine cell differentiation pre-mRNA binding glucose homeostasis entrainment of circadian clock by photoperiod mRNA cis splicing, via spliceosome positive regulation of translation negative regulation of translational initiation regulation of insulin receptor signaling pathway response to arsenic-containing substance regulation of nucleocytoplasmic transport metal ion binding perinuclear region of cytoplasm positive regulation of muscle cell differentiation pre-mRNA intronic binding pre-mRNA intronic pyrimidine-rich binding circadian regulation of translation uc008gau.1 uc008gau.2 uc008gau.3 
ENSMUST00000180251.9 Erdr1x ENSMUST00000180251.9 Erdr1x (from geneSymbol) ENSMUST00000180251.1 ENSMUST00000180251.2 ENSMUST00000180251.3 ENSMUST00000180251.4 ENSMUST00000180251.5 ENSMUST00000180251.6 ENSMUST00000180251.7 ENSMUST00000180251.8 uc292rvb.1 uc292rvb.2 uc292rvb.3 uc292rvb.1 uc292rvb.2 uc292rvb.3 
ENSMUST00000180252.3 Tmem151b ENSMUST00000180252.3 transmembrane protein 151B (from RefSeq NM_001013749.3) ENSMUST00000180252.1 ENSMUST00000180252.2 Gm323 NM_001013749 Q5XJV8 Q68FE7 T151B_MOUSE uc008cqu.1 uc008cqu.2 uc008cqu.3 uc008cqu.4 Membrane ; Multi-pass membrane protein Belongs to the TMEM151 family. molecular_function cellular_component biological_process membrane integral component of membrane uc008cqu.1 uc008cqu.2 uc008cqu.3 uc008cqu.4 
ENSMUST00000180260.8 Sanbr ENSMUST00000180260.8 SANT and BTB domain regulator of CSR, transcript variant 1 (from RefSeq NM_027860.3) A2AF87 A2AF88 A2AF89 A2AF91 A2AF92 ENSMUST00000180260.1 ENSMUST00000180260.2 ENSMUST00000180260.3 ENSMUST00000180260.4 ENSMUST00000180260.5 ENSMUST00000180260.6 ENSMUST00000180260.7 Kiaa1841 NM_027860 Q3UQL0 Q68FF0 Q6GQU5 Q6ZPH2 Q8BPK6 Q9CWA7 SANBR_MOUSE Sanbr uc007ifh.1 uc007ifh.2 uc007ifh.3 Negatively regulates class switch recombination or isotype switching in splenic B-cells. Homodimer (PubMed:33831416). Interacts (via the BTB domain) with HDAC1 and NCOR2 (PubMed:33831416). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q68FF0-1; Sequence=Displayed; Name=2; IsoId=Q68FF0-2; Sequence=VSP_032303; The BTB domain is important for homodimerization and for its function in negative regulation of class switch recombination. Belongs to the KIAA1841 family. Sequence=AAH72622.1; Type=Frameshift; Evidence=; Sequence=BAC98264.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=CAM16941.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM16943.1; Type=Erroneous gene model prediction; Evidence=; Sequence=CAM16946.1; Type=Erroneous gene model prediction; Evidence=; molecular_function cellular_component biological_process uc007ifh.1 uc007ifh.2 uc007ifh.3 
ENSMUST00000180266.2 Ighd3-1 ENSMUST00000180266.2 Ighd3-1 (from geneSymbol) ENSMUST00000180266.1 uc288jsz.1 uc288jsz.2 uc288jsz.1 uc288jsz.2 
ENSMUST00000180280.3 n-R5s119 ENSMUST00000180280.3 n-R5s119 (from geneSymbol) ENSMUST00000180280.1 ENSMUST00000180280.2 uc292dzg.1 uc292dzg.2 uc292dzg.1 uc292dzg.2 
ENSMUST00000180281.2 Astx6 ENSMUST00000180281.2 amplified spermatogenic transcripts X encoded 6 (from RefSeq NR_152852.1) ENSMUST00000180281.1 NR_152852 uc292qih.1 uc292qih.2 uc292qih.1 uc292qih.2 
ENSMUST00000180282.2 Fam240b ENSMUST00000180282.2 family with sequence similarity 240 member B (from RefSeq NM_001195435.1) 1190003K10Rik ENSMUST00000180282.1 Fam240b J3QMB3 J3QMB3_MOUSE NM_001195435 uc011zbb.1 uc011zbb.2 molecular_function cellular_component biological_process uc011zbb.1 uc011zbb.2 
ENSMUST00000180285.3 Eif1ad17 ENSMUST00000180285.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. (from UniProt J3QMW5) ENSMUST00000180285.1 ENSMUST00000180285.2 Eif1ad17 J3QMW5 J3QMW5_MOUSE uc288ifi.1 uc288ifi.2 uc288ifi.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. RNA binding translation initiation factor activity translation translational initiation uc288ifi.1 uc288ifi.2 uc288ifi.3 
ENSMUST00000180288.2 H2bc24 ENSMUST00000180288.2 H2B clustered histone 24, transcript variant 1 (from RefSeq NM_001110555.1) ENSMUST00000180288.1 H2bc23 H2bc24 NM_001110555 Q8CBB6 Q8CBB6_MOUSE uc007prw.1 uc007prw.2 uc007prw.3 uc007prw.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Sep 2015]. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2B family. nucleosome DNA binding nucleus nucleoplasm chromosome cytosol biological_process enzyme binding macromolecular complex ubiquitin-like protein ligase binding protein heterodimerization activity STAT family protein binding uc007prw.1 uc007prw.2 uc007prw.3 uc007prw.4 
ENSMUST00000180291.2 ENSMUSG00000094722 ENSMUST00000180291.2 ENSMUSG00000094722 (from geneSymbol) BC099967 ENSMUST00000180291.1 uc291cfh.1 uc291cfh.2 uc291cfh.1 uc291cfh.2 
ENSMUST00000180297.2 Krtap10-33 ENSMUST00000180297.2 predicted gene, 19402 (from RefSeq NM_001205032.2) ENSMUST00000180297.1 Gm19402 J3QJV4 J3QJV4_MOUSE NM_001205032 uc029qzn.1 uc029qzn.2 intermediate filament keratin filament uc029qzn.1 uc029qzn.2 
ENSMUST00000180303.2 ENSMUSG00000095523 ENSMUST00000180303.2 ENSMUSG00000095523 (from geneSymbol) BC099967 ENSMUST00000180303.1 uc291cfs.1 uc291cfs.2 uc291cfs.1 uc291cfs.2 
ENSMUST00000180309.3 Gm21917 ENSMUST00000180309.3 Gm21917 (from geneSymbol) ENSMUST00000180309.1 ENSMUST00000180309.2 uc289bim.1 uc289bim.2 uc289bim.3 uc289bim.1 uc289bim.2 uc289bim.3 
ENSMUST00000180325.2 Gm26436 ENSMUST00000180325.2 Gm26436 (from geneSymbol) ENSMUST00000180325.1 uc290kzz.1 uc290kzz.2 uc290kzz.1 uc290kzz.2 
ENSMUST00000180339.8 4931406C07Rik ENSMUST00000180339.8 RIKEN cDNA 4931406C07 gene, transcript variant 1 (from RefSeq NM_001199484.1) CK054_MOUSE ENSMUST00000180339.1 ENSMUST00000180339.2 ENSMUST00000180339.3 ENSMUST00000180339.4 ENSMUST00000180339.5 ENSMUST00000180339.6 ENSMUST00000180339.7 NM_001199484 Q91V76 uc009ofo.1 uc009ofo.2 uc009ofo.3 Exhibits ester hydrolase activity on the substrate p- nitrophenyl acetate. Monomer. Nucleus nucleus nucleoplasm zinc ion binding nuclear body hydrolase activity hydrolase activity, acting on ester bonds metal ion binding uc009ofo.1 uc009ofo.2 uc009ofo.3 
ENSMUST00000180344.8 Gm10487 ENSMUST00000180344.8 predicted gene 10487 (from RefSeq NM_001100609.1) ENSMUST00000180344.1 ENSMUST00000180344.2 ENSMUST00000180344.3 ENSMUST00000180344.4 ENSMUST00000180344.5 ENSMUST00000180344.6 ENSMUST00000180344.7 Gm10058 Gm10096 Gm10147 Gm10230 Gm10486 Gm10487 Gm14632 Gm14819 Gm4836 NM_001100609 Q62478 Q62478_MOUSE XMR uc009swr.1 uc009swr.2 uc009swr.3 uc009swr.4 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function nucleus spermatogenesis spermatid development meiotic cell cycle uc009swr.1 uc009swr.2 uc009swr.3 uc009swr.4 
ENSMUST00000180347.2 Cwc22rt4 ENSMUST00000180347.2 Nucleus speckle (from UniProt A2AK42) A2AK42 A2AK42_MOUSE Cwc22rt1 Cwc22rt2 Cwc22rt4 Cwc22rt5 Cwc22rt6 Cwc22rt7 ENSMUST00000180347.1 uc289xka.1 uc289xka.2 Nucleus speckle Belongs to the CWC22 family. mRNA splicing, via spliceosome RNA binding catalytic step 2 spliceosome uc289xka.1 uc289xka.2 
ENSMUST00000180353.2 Sox1 ENSMUST00000180353.2 SRY (sex determining region Y)-box 1 (from RefSeq NM_009233.3) ENSMUST00000180353.1 NM_009233 P53783 Q80XF2 SOX1_MOUSE Sox-1 uc009kwa.1 uc009kwa.2 uc009kwa.3 uc009kwa.4 Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). Nucleus Mainly in the developing central nervous system. Expressed in developing urogenital ridge. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding neuron migration lens morphogenesis in camera-type eye DNA binding nucleus regulation of transcription, DNA-templated nervous system development ventral spinal cord interneuron specification forebrain neuron differentiation forebrain neuron development cell differentiation forebrain development sequence-specific DNA binding nuclear transcription factor complex positive regulation of transcription from RNA polymerase II promoter cellular response to leukemia inhibitory factor uc009kwa.1 uc009kwa.2 uc009kwa.3 uc009kwa.4 
ENSMUST00000180357.2 Gm15100 ENSMUST00000180357.2 Gm15100 (from geneSymbol) ENSMUST00000180357.1 uc292rbh.1 uc292rbh.2 uc292rbh.1 uc292rbh.2 
ENSMUST00000180359.8 Abhd4 ENSMUST00000180359.8 abhydrolase domain containing 4, transcript variant 2 (from RefSeq NM_001205181.1) Abhd4 ENSMUST00000180359.1 ENSMUST00000180359.2 ENSMUST00000180359.3 ENSMUST00000180359.4 ENSMUST00000180359.5 ENSMUST00000180359.6 ENSMUST00000180359.7 NM_001205181 Q8C0M2 Q8C0M2_MOUSE uc007tvo.1 uc007tvo.2 uc007tvo.3 uc007tvo.4 uc007tvo.1 uc007tvo.2 uc007tvo.3 uc007tvo.4 
ENSMUST00000180360.8 Ehbp1 ENSMUST00000180360.8 EH domain binding protein 1, transcript variant 2 (from RefSeq NM_153078.4) E9QMJ9 EHBP1_MOUSE ENSMUST00000180360.1 ENSMUST00000180360.2 ENSMUST00000180360.3 ENSMUST00000180360.4 ENSMUST00000180360.5 ENSMUST00000180360.6 ENSMUST00000180360.7 Kiaa0903 NM_153078 Q5SQK3 Q69ZW3 Q91ZJ6 uc007iea.1 uc007iea.2 uc007iea.3 uc007iea.4 uc007iea.5 May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes. Interacts with EHD1 (PubMed:15247266). Interacts with EHD2. Interacts with RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); at least in case of RAB8A may bind 2 molecules of RAB8A simultaneously through a high and a low affinity binding site, respectively (By similarity). Cytoplasm Membrane Endosome Note=Mostly found in cytosol and plasma membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69ZW3-1; Sequence=Displayed; Name=2; IsoId=Q69ZW3-2; Sequence=VSP_024836; The CAAX motif is a signal for prenylation and required for endosomal colocalization with Rab8 and Rab10. The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound form). Prenylated (Probable). Farnelysation (predominant) and geranylgeranylation has been observed in vitro. Sequence=BAD32333.1; Type=Erroneous initiation; Evidence=; protein binding cytoplasm endosome microtubule organizing center cytosol plasma membrane endocytosis protein transport membrane actin cytoskeleton organization filamentous actin uc007iea.1 uc007iea.2 uc007iea.3 uc007iea.4 uc007iea.5 
ENSMUST00000180376.8 Fam193a ENSMUST00000180376.8 family with sequence homology 193, member A (from RefSeq NM_001243123.2) ENSMUST00000180376.1 ENSMUST00000180376.2 ENSMUST00000180376.3 ENSMUST00000180376.4 ENSMUST00000180376.5 ENSMUST00000180376.6 ENSMUST00000180376.7 Fam193a M0QWZ1 M0QWZ1_MOUSE NM_001243123 uc008xcg.1 uc008xcg.2 uc008xcg.3 uc008xcg.4 Belongs to the FAM193 family. uc008xcg.1 uc008xcg.2 uc008xcg.3 uc008xcg.4 
ENSMUST00000180378.2 Gm6345 ENSMUST00000180378.2 predicted gene 6345 (from RefSeq NR_151590.1) ENSMUST00000180378.1 NR_151590 uc287npt.1 uc287npt.2 uc287npt.1 uc287npt.2 
ENSMUST00000180380.3 Trav13-4-dv7 ENSMUST00000180380.3 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A075B6C2) A0A075B6C2 A0A075B6C2_MOUSE ENSMUST00000180380.1 ENSMUST00000180380.2 M26299 Trav13-4-dv7 uc057bfb.1 uc057bfb.2 uc057bfb.3 uc057bfb.4 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc057bfb.1 uc057bfb.2 uc057bfb.3 uc057bfb.4 
ENSMUST00000180386.3 Gm26614 ENSMUST00000180386.3 Gm26614 (from geneSymbol) AK139159 ENSMUST00000180386.1 ENSMUST00000180386.2 uc292lzw.1 uc292lzw.2 uc292lzw.3 uc292lzw.1 uc292lzw.2 uc292lzw.3 
ENSMUST00000180387.3 Ctxnd1 ENSMUST00000180387.3 cortexin domain containing 1 (from RefSeq NM_001384188.1) A0A1B0GST9 CTXD1_MOUSE Ctxnd1 ENSMUST00000180387.1 ENSMUST00000180387.2 NM_001384188 uc009iei.1 uc009iei.2 uc009iei.3 uc009iei.4 Membrane ; Single-pass membrane protein membrane integral component of membrane uc009iei.1 uc009iei.2 uc009iei.3 uc009iei.4 
ENSMUST00000180396.2 Rps18-ps4 ENSMUST00000180396.2 ribosomal protein S18, pseudogene 4 (from RefSeq NR_152263.1) ENSMUST00000180396.1 NR_152263 uc288pjm.1 uc288pjm.2 uc288pjm.1 uc288pjm.2 
ENSMUST00000180403.4 Gm26806 ENSMUST00000180403.4 Gm26806 (from geneSymbol) AK076976 ENSMUST00000180403.1 ENSMUST00000180403.2 ENSMUST00000180403.3 uc288obl.1 uc288obl.2 uc288obl.3 uc288obl.1 uc288obl.2 uc288obl.3 
ENSMUST00000180406.2 Gm26748 ENSMUST00000180406.2 Gm26748 (from geneSymbol) AK032234 ENSMUST00000180406.1 uc291hkv.1 uc291hkv.2 uc291hkv.1 uc291hkv.2 
ENSMUST00000180413.2 Gm26621 ENSMUST00000180413.2 Gm26621 (from geneSymbol) ENSMUST00000180413.1 uc288ymy.1 uc288ymy.2 uc288ymy.1 uc288ymy.2 
ENSMUST00000180418.2 Gm26854 ENSMUST00000180418.2 Gm26854 (from geneSymbol) AK085881 ENSMUST00000180418.1 uc007vow.1 uc007vow.2 uc007vow.1 uc007vow.2 
ENSMUST00000180425.2 Gm26736 ENSMUST00000180425.2 Gm26736 (from geneSymbol) ENSMUST00000180425.1 uc291cjf.1 uc291cjf.2 uc291cjf.1 uc291cjf.2 
ENSMUST00000180426.4 Gm26881 ENSMUST00000180426.4 Gm26881 (from geneSymbol) AK043958 ENSMUST00000180426.1 ENSMUST00000180426.2 ENSMUST00000180426.3 uc008spe.1 uc008spe.2 uc008spe.3 uc008spe.4 uc008spe.1 uc008spe.2 uc008spe.3 uc008spe.4 
ENSMUST00000180427.2 Gm6999 ENSMUST00000180427.2 Gm6999 (from geneSymbol) AK135767 ENSMUST00000180427.1 uc007utk.1 uc007utk.2 uc007utk.3 uc007utk.4 uc007utk.5 uc007utk.6 uc007utk.1 uc007utk.2 uc007utk.3 uc007utk.4 uc007utk.5 uc007utk.6 
ENSMUST00000180434.2 Gm26724 ENSMUST00000180434.2 Gm26724 (from geneSymbol) AK139599 ENSMUST00000180434.1 uc289irt.1 uc289irt.2 uc289irt.1 uc289irt.2 
ENSMUST00000180436.2 Ascl5 ENSMUST00000180436.2 achaete-scute family bHLH transcription factor 5 (from RefSeq NM_001270609.2) ASCL5_MOUSE AmeloD Ascl5 ENSMUST00000180436.1 M0QWB7 NM_001270609 bHLHa47 uc033fly.1 uc033fly.2 Transcription factor (PubMed:30426815). Probably binds E-box motifs 5'-CANNTG-3' in complex with transcription factor TCF3/E12 (PubMed:30426815). Negatively modulates transcription of target genes such as CDH1/E-cadherin, perhaps by recruiting the PRC2 repressive complex to regulatory elements (PubMed:30426815, PubMed:30504223). Regulates ameloblast development and tooth germ growth, perhaps acting by positively modulating migration of inner enamel epithelium (IEE) cells (PubMed:30426815, PubMed:30504223, PubMed:34812512). Plays a role in enamel formation (PubMed:34812512). Interacts with transcription factor TCF3/E12. Nucleus Expressed in teeth (at protein level). Expressed in inner enamel epithelium (IEE) cells of molars at 14 dpc and 17 dpc, during ameloblast development (at protein level) (PubMed:30426815, PubMed:34812512). Expressed in molars and incisors at postnatal day 1 (P1) (at protein level) (PubMed:30426815). Expressed in Hertwig epithelial root sheath (HERS) cells during molar development (at protein level) (PubMed:30426815). Earliest expression in the incisor region at 11 dpc (PubMed:30426815). Knockout mice are fertile, but have enamel hypoplasia and small teeth (PubMed:30504223, PubMed:34812512). Abnormal ectopic expression of CDH1/E-cadherin in inner enamel epithelium (IEE) cells, but not in cells of the stratum intermedium (SI) at postnatal day 1 (P1) (PubMed:30504223). Inhibits the growth of clipped incisors (PubMed:30504223). Significantly reduces mRNA levels of SOX21, AMBN, ENAM, and AMELX in molars at P1 (PubMed:34812512). Develops fewer, smaller, incisors at 3 months of age in a transcription factor SP6/Epfn knockout background (PubMed:30504223). Epithelial cell invasion is inhibited and CDH1 ectopically expressed in dental epithelial cells at 3 months of age, in an SP6 knockout background (PubMed:30504223). negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding DNA binding regulation of transcription from RNA polymerase II promoter transcription factor binding protein dimerization activity RNA polymerase II transcription factor complex transcription factor activity, sequence-specific DNA binding uc033fly.1 uc033fly.2 
ENSMUST00000180441.2 AU022754 ENSMUST00000180441.2 expressed sequence AU022754 (from RefSeq NR_040433.1) ENSMUST00000180441.1 NR_040433 uc007xdh.1 uc007xdh.2 uc007xdh.1 uc007xdh.2 
ENSMUST00000180443.3 Gm26542 ENSMUST00000180443.3 Gm26542 (from geneSymbol) AK157916 ENSMUST00000180443.1 ENSMUST00000180443.2 uc007isc.1 uc007isc.2 uc007isc.1 uc007isc.2 
ENSMUST00000180447.3 Gm3510 ENSMUST00000180447.3 predicted gene 3510 (from RefSeq NR_188791.1) ENSMUST00000180447.1 ENSMUST00000180447.2 NR_188791 uc290tgy.1 uc290tgy.2 uc290tgy.3 uc290tgy.1 uc290tgy.2 uc290tgy.3 
ENSMUST00000180458.9 Tunar ENSMUST00000180458.9 Tcl1 upstream neural differentiation associated RNA, transcript variant 1 (from RefSeq NM_001416144.1) A0A1B0GQX2 ENSMUST00000180458.1 ENSMUST00000180458.2 ENSMUST00000180458.3 ENSMUST00000180458.4 ENSMUST00000180458.5 ENSMUST00000180458.6 ENSMUST00000180458.7 ENSMUST00000180458.8 NM_001416144 TUNAR_MOUSE Tunar uc007oyf.1 uc007oyf.2 uc007oyf.3 In neurons, plays a role in the regulation of intracellular Ca(2+), possibly by acting as an activator of ATP2A2/SERCA2, thus increasing the efficiency with which Ca(2+) is removed from the cytoplasm (PubMed:35036403). Inhibits differentiation of embryonic stem cells into neurons and inhibits neurite outgrowth, likely as a result of its role in intracellular Ca(2+) regulation (PubMed:35036403). In pancreatic beta cells, lowers Ca(2+) levels in the endoplasmic reticulum and enhances glucose-stimulated insulin secretion (By similarity). Interacts with ATPase ATP2A2/SERCA2 (PubMed:35036403). Interacts with ATPase ATP2A3/SERCA3; the interaction occurs at low levels in low glucose conditions and is increased by high glucose levels (By similarity). Endoplasmic reticulum membrane ; Single-pass membrane protein Extracellular vesicle membrane ; Single-pass membrane protein In the adult, expressed in Purkinje cells in the cerebellum, in motor neurons and interneurons in the spinal cord and in neurons of the cortex, hippocampus and thalamus (at protein level) (PubMed:35036403). Also detected in the developing cortex, hippocampus and thalamus at embryonic day E15.5 (at protein level) (PubMed:35036403). membrane integral component of membrane uc007oyf.1 uc007oyf.2 uc007oyf.3 
ENSMUST00000180463.3 Rd3 ENSMUST00000180463.3 retinal degeneration 3, transcript variant 1 (from RefSeq NM_023727.4) ENSMUST00000180463.1 ENSMUST00000180463.2 NM_023727 Q3SYJ8 Q8BRE0 Q9CRS3 Q9JMF2 RD3_MOUSE uc007edd.1 uc007edd.2 uc007edd.3 uc007edd.4 uc007edd.5 uc007edd.6 Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors (PubMed:21078983, PubMed:27471269). Inhibits the basal catalytic activity and the GCAP- stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors (PubMed:27471269). Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment (PubMed:21078983). Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP (By similarity). Plays an important role for the survival of rods and cones in the retina (PubMed:8486383, PubMed:17186464). Monomer (By similarity). Interacts with GUCY2E; promotes the exit of GUCY2E from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (PubMed:21078983). The interaction with GUCY2E negatively regulates its activity (By similarity). Interacts with GUCY2F; promotes the exit of GUCY2F from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (PubMed:21078983). The interaction with GUCY2F negatively regulates its activity (By similarity). Interacts with GUK1; up-regulates GUK1 activity (By similarity). Cell projection, cilium, photoreceptor outer segment Photoreceptor inner segment dosome Nucleus Cytoplasm Cytoplasm, perinuclear region Note=Colocalizes with GUCY2E and GUCY2F in rods and cones photoreceptors. Colocalizes with GUK1 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer (PubMed:29515371). Strong dot-like perinuclear staining in the epithelial cells (By similarity). Expressed in the retina and in particular in the inner nuclear layer, in rod and cone outer segments, in the outer nuclear layer, in the outer plexiform layer and in the ganglion cell layer. Note=A spontaneous mutation leading to a frameshift and in an unstable truncated protein lacking the C-terminal 89 amino acids causes retinal degeneration. Homozygotes mice (called rd-3) display retinal degeneration, beginning at 3 weeks of age, characterized by complete loss of photoreceptor rod cells by 5 weeks, and cones by 8 weeks. Sequence=BAA92758.1; Type=Frameshift; Evidence=; Sequence=BAB29312.2; Type=Erroneous initiation; Evidence=; visual perception response to stimulus retina development in camera-type eye uc007edd.1 uc007edd.2 uc007edd.3 uc007edd.4 uc007edd.5 uc007edd.6 
ENSMUST00000180464.2 Gm26596 ENSMUST00000180464.2 Gm26596 (from geneSymbol) AK143218 ENSMUST00000180464.1 uc287uws.1 uc287uws.2 uc287uws.1 uc287uws.2 
ENSMUST00000180469.2 Gm26769 ENSMUST00000180469.2 Gm26769 (from geneSymbol) ENSMUST00000180469.1 uc289eem.1 uc289eem.2 uc289eem.1 uc289eem.2 
ENSMUST00000180485.2 Gm26838 ENSMUST00000180485.2 predicted gene, 26838 (from RefSeq NR_188890.1) ENSMUST00000180485.1 NR_188890 uc289ejn.1 uc289ejn.2 uc289ejn.1 uc289ejn.2 
ENSMUST00000180488.8 B230323A14Rik ENSMUST00000180488.8 B230323A14Rik (from geneSymbol) AK045913 ENSMUST00000180488.1 ENSMUST00000180488.2 ENSMUST00000180488.3 ENSMUST00000180488.4 ENSMUST00000180488.5 ENSMUST00000180488.6 ENSMUST00000180488.7 uc009qnj.1 uc009qnj.2 uc009qnj.3 uc009qnj.4 uc009qnj.1 uc009qnj.2 uc009qnj.3 uc009qnj.4 
ENSMUST00000180489.10 Mirt1 ENSMUST00000180489.10 myocardial infarction associated transcript 1 (from RefSeq NR_028427.1) ENSMUST00000180489.1 ENSMUST00000180489.2 ENSMUST00000180489.3 ENSMUST00000180489.4 ENSMUST00000180489.5 ENSMUST00000180489.6 ENSMUST00000180489.7 ENSMUST00000180489.8 ENSMUST00000180489.9 NR_028427 uc008hwu.1 uc008hwu.2 uc008hwu.3 uc008hwu.4 uc008hwu.5 uc008hwu.1 uc008hwu.2 uc008hwu.3 uc008hwu.4 uc008hwu.5 
ENSMUST00000180491.2 6430562O15Rik ENSMUST00000180491.2 6430562O15Rik (from geneSymbol) AK052076 ENSMUST00000180491.1 uc288plw.1 uc288plw.2 uc288plw.1 uc288plw.2 
ENSMUST00000180496.3 Gm26568 ENSMUST00000180496.3 Gm26568 (from geneSymbol) AK016925 ENSMUST00000180496.1 ENSMUST00000180496.2 uc287mcc.1 uc287mcc.2 uc287mcc.3 uc287mcc.1 uc287mcc.2 uc287mcc.3 
ENSMUST00000180502.8 Zfp850 ENSMUST00000180502.8 zinc finger protein 850 (from RefSeq NM_001254951.1) A0A087WSI7 ENSMUST00000180502.1 ENSMUST00000180502.2 ENSMUST00000180502.3 ENSMUST00000180502.4 ENSMUST00000180502.5 ENSMUST00000180502.6 ENSMUST00000180502.7 Gm4636 J3QPC5 J3QPC5_MOUSE NM_001254951 Zfp850 uc029wed.1 uc029wed.2 uc029wed.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc029wed.1 uc029wed.2 uc029wed.3 
ENSMUST00000180505.3 Gm10814 ENSMUST00000180505.3 predicted gene 10814 (from RefSeq NR_045783.1) ENSMUST00000180505.1 ENSMUST00000180505.2 NR_045783 uc008ggl.1 uc008ggl.2 uc008ggl.3 uc008ggl.4 uc008ggl.5 uc008ggl.1 uc008ggl.2 uc008ggl.3 uc008ggl.4 uc008ggl.5 
ENSMUST00000180509.10 G730013B05Rik ENSMUST00000180509.10 G730013B05Rik (from geneSymbol) AK144624 ENSMUST00000180509.1 ENSMUST00000180509.2 ENSMUST00000180509.3 ENSMUST00000180509.4 ENSMUST00000180509.5 ENSMUST00000180509.6 ENSMUST00000180509.7 ENSMUST00000180509.8 ENSMUST00000180509.9 uc007zkw.1 uc007zkw.2 uc007zkw.3 uc007zkw.4 uc007zkw.5 uc007zkw.1 uc007zkw.2 uc007zkw.3 uc007zkw.4 uc007zkw.5 
ENSMUST00000180515.3 C430042M11Rik ENSMUST00000180515.3 RIKEN cDNA C430042M11 gene, transcript variant 1 (from RefSeq NR_155490.1) ENSMUST00000180515.1 ENSMUST00000180515.2 NR_155490 uc289nel.1 uc289nel.2 uc289nel.3 uc289nel.1 uc289nel.2 uc289nel.3 
ENSMUST00000180516.3 Gm10544 ENSMUST00000180516.3 predicted gene 10544 (from RefSeq NR_188735.1) ENSMUST00000180516.1 ENSMUST00000180516.2 NR_188735 uc008epl.1 uc008epl.2 uc008epl.3 uc008epl.1 uc008epl.2 uc008epl.3 
ENSMUST00000180521.2 1810049J17Rik ENSMUST00000180521.2 1810049J17Rik (from geneSymbol) 1810049J17Rik AK131847 ENSMUST00000180521.1 Golph3 Q3V2G9 Q3V2G9_MOUSE uc288xbb.1 uc288xbb.2 uc288xbb.1 uc288xbb.2 
ENSMUST00000180524.8 D030068K23Rik ENSMUST00000180524.8 RIKEN cDNA D030068K23 gene (from RefSeq NR_126329.1) ENSMUST00000180524.1 ENSMUST00000180524.2 ENSMUST00000180524.3 ENSMUST00000180524.4 ENSMUST00000180524.5 ENSMUST00000180524.6 ENSMUST00000180524.7 NR_126329 uc009nie.1 uc009nie.2 uc009nie.1 uc009nie.2 
ENSMUST00000180527.2 4930540M05Rik ENSMUST00000180527.2 4930540M05Rik (from geneSymbol) AK016012 ENSMUST00000180527.1 uc291iih.1 uc291iih.2 uc291iih.1 uc291iih.2 
ENSMUST00000180529.2 B230208H11Rik ENSMUST00000180529.2 RIKEN cDNA B230208H11 gene, transcript variant 1 (from RefSeq NR_038027.1) ENSMUST00000180529.1 NR_038027 uc007ekf.1 uc007ekf.2 uc007ekf.3 uc007ekf.4 uc007ekf.1 uc007ekf.2 uc007ekf.3 uc007ekf.4 
ENSMUST00000180534.4 3110083C13Rik ENSMUST00000180534.4 RIKEN cDNA 3110083C13 gene (from RefSeq NR_166770.1) ENSMUST00000180534.1 ENSMUST00000180534.2 ENSMUST00000180534.3 NR_166770 uc007udw.1 uc007udw.2 uc007udw.3 uc007udw.4 uc007udw.1 uc007udw.2 uc007udw.3 uc007udw.4 
ENSMUST00000180542.2 Gm26620 ENSMUST00000180542.2 Gm26620 (from geneSymbol) ENSMUST00000180542.1 Gm26620 Q9CY65 Q9CY65_MOUSE uc287nqn.1 uc287nqn.2 uc287nqn.1 uc287nqn.2 
ENSMUST00000180544.3 Zfp950 ENSMUST00000180544.3 zinc finger protein 950, transcript variant 1 (from RefSeq NM_001309216.2) A0A0U1RQ46 A0A0U1RQ46_MOUSE ENSMUST00000180544.1 ENSMUST00000180544.2 NM_001309216 Zfp950 uc057bmb.1 uc057bmb.2 uc057bmb.3 vasculogenesis kidney development molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated nitrogen compound metabolic process post-embryonic development smooth muscle cell migration hemopoiesis multicellular organism growth metal ion binding platelet-derived growth factor receptor signaling pathway skeletal system morphogenesis smooth muscle tissue development palate development face morphogenesis uc057bmb.1 uc057bmb.2 uc057bmb.3 
ENSMUST00000180549.3 Trav6-3 ENSMUST00000180549.3 Trav6-3 (from geneSymbol) AK134090 ENSMUST00000180549.1 ENSMUST00000180549.2 Q5R1E6 Q5R1E6_MOUSE TRAV6-3 TRAV6D-3 Trav6-3 uc007tsc.1 uc007tsc.2 uc007tsc.3 uc007tsc.4 uc007tsc.5 uc007tsc.6 immunoglobulin production molecular_function extracellular space immune response uc007tsc.1 uc007tsc.2 uc007tsc.3 uc007tsc.4 uc007tsc.5 uc007tsc.6 
ENSMUST00000180558.9 F630040K05Rik ENSMUST00000180558.9 RIKEN cDNA F630040K05 gene (from RefSeq NR_152153.1) ENSMUST00000180558.1 ENSMUST00000180558.2 ENSMUST00000180558.3 ENSMUST00000180558.4 ENSMUST00000180558.5 ENSMUST00000180558.6 ENSMUST00000180558.7 ENSMUST00000180558.8 NR_152153 uc289ljp.1 uc289ljp.2 uc289ljp.1 uc289ljp.2 
ENSMUST00000180559.2 Gm26558 ENSMUST00000180559.2 Gm26558 (from geneSymbol) AK041069 ENSMUST00000180559.1 uc289wtc.1 uc289wtc.2 uc289wtc.1 uc289wtc.2 
ENSMUST00000180570.4 G730003C15Rik ENSMUST00000180570.4 G730003C15Rik (from geneSymbol) AK144579 ENSMUST00000180570.1 ENSMUST00000180570.2 ENSMUST00000180570.3 uc287ild.1 uc287ild.2 uc287ild.3 uc287ild.4 uc287ild.1 uc287ild.2 uc287ild.3 uc287ild.4 
ENSMUST00000180571.2 4933433F19Rik ENSMUST00000180571.2 RIKEN cDNA 4933433F19 gene (from RefSeq NR_045856.1) ENSMUST00000180571.1 NR_045856 uc029wsd.1 uc029wsd.2 uc029wsd.3 uc029wsd.1 uc029wsd.2 uc029wsd.3 
ENSMUST00000180572.2 Agrn ENSMUST00000180572.2 agrin, transcript variant 1 (from RefSeq NM_021604.3) Agrn ENSMUST00000180572.1 M0QWP1 M0QWP1_MOUSE NM_021604 uc008wgf.1 uc008wgf.2 uc008wgf.3 uc008wgf.4 Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding basement membrane cytosol plasma membrane G-protein coupled acetylcholine receptor signaling pathway regulation of synaptic growth at neuromuscular junction receptor clustering laminin binding uc008wgf.1 uc008wgf.2 uc008wgf.3 uc008wgf.4 
ENSMUST00000180586.3 Gm26770 ENSMUST00000180586.3 Gm26770 (from geneSymbol) AK082339 ENSMUST00000180586.1 ENSMUST00000180586.2 uc291jfn.1 uc291jfn.2 uc291jfn.1 uc291jfn.2 
ENSMUST00000180587.8 Tnfsfm13 ENSMUST00000180587.8 tumor necrosis factor (ligand) superfamily, membrane-bound member 13, transcript variant 1 (from RefSeq NM_001034097.2) ENSMUST00000180587.1 ENSMUST00000180587.2 ENSMUST00000180587.3 ENSMUST00000180587.4 ENSMUST00000180587.5 ENSMUST00000180587.6 ENSMUST00000180587.7 NM_001034097 Q8BXS2 Q8BXS2_MOUSE Tnfsfm13 uc007jrg.1 uc007jrg.2 uc007jrg.3 This gene represents read-through transcription between neighboring genes encoding tumor necrosis factor family members. This results a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The homologous fusion protein in human is known to be membrane-anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. Alternative splicing of this mouse gene results in multiple transcript variants. [provided by RefSeq, Oct 2010]. Secreted Belongs to the tumor necrosis factor family. molecular_function cytokine activity tumor necrosis factor receptor binding cellular_component extracellular space immune response signal transduction biological_process membrane integral component of membrane uc007jrg.1 uc007jrg.2 uc007jrg.3 
ENSMUST00000180598.3 Gm10516 ENSMUST00000180598.3 predicted gene 10516 (from RefSeq NR_033536.1) ENSMUST00000180598.1 ENSMUST00000180598.2 NR_033536 uc007edm.1 uc007edm.2 uc007edm.3 uc007edm.1 uc007edm.2 uc007edm.3 
ENSMUST00000180599.2 Gm10287 ENSMUST00000180599.2 predicted gene 10287 (from RefSeq NR_189033.1) ENSMUST00000180599.1 NR_189033 uc290kms.1 uc290kms.2 uc290kms.1 uc290kms.2 
ENSMUST00000180602.8 Gm26893 ENSMUST00000180602.8 Gm26893 (from geneSymbol) ENSMUST00000180602.1 ENSMUST00000180602.2 ENSMUST00000180602.3 ENSMUST00000180602.4 ENSMUST00000180602.5 ENSMUST00000180602.6 ENSMUST00000180602.7 uc288qml.1 uc288qml.2 uc288qml.1 uc288qml.2 
ENSMUST00000180603.8 Gm16958 ENSMUST00000180603.8 predicted gene, 16958, transcript variant 2 (from RefSeq NR_105030.1) ENSMUST00000180603.1 ENSMUST00000180603.2 ENSMUST00000180603.3 ENSMUST00000180603.4 ENSMUST00000180603.5 ENSMUST00000180603.6 ENSMUST00000180603.7 NR_105030 uc033hzm.1 uc033hzm.2 uc033hzm.3 uc033hzm.1 uc033hzm.2 uc033hzm.3 
ENSMUST00000180604.2 4930556M19Rik ENSMUST00000180604.2 RIKEN cDNA 4930556M19 gene, transcript variant 1 (from RefSeq NR_045063.1) ENSMUST00000180604.1 NR_045063 uc007vgs.1 uc007vgs.2 uc007vgs.1 uc007vgs.2 
ENSMUST00000180609.2 A330032B11Rik ENSMUST00000180609.2 RIKEN cDNA A330032B11 gene (from RefSeq NR_045329.1) ENSMUST00000180609.1 NR_045329 uc008hid.1 uc008hid.2 uc008hid.1 uc008hid.2 
ENSMUST00000180611.8 Dmxl1 ENSMUST00000180611.8 Dmx-like 1 (from RefSeq NM_001081371.2) DMXL1_MOUSE ENSMUST00000180611.1 ENSMUST00000180611.2 ENSMUST00000180611.3 ENSMUST00000180611.4 ENSMUST00000180611.5 ENSMUST00000180611.6 ENSMUST00000180611.7 NM_001081371 Q3TLG8 Q6PHM6 Q6PNC0 Q8BQF2 uc008ewo.1 uc008ewo.2 uc008ewo.3 uc008ewo.4 Sequence=BAE38824.1; Type=Erroneous initiation; Evidence=; molecular_function vacuolar acidification RAVE complex uc008ewo.1 uc008ewo.2 uc008ewo.3 uc008ewo.4 
ENSMUST00000180612.4 9330175E14Rik ENSMUST00000180612.4 9330175E14Rik (from geneSymbol) AK080381 ENSMUST00000180612.1 ENSMUST00000180612.2 ENSMUST00000180612.3 uc292ceu.1 uc292ceu.2 uc292ceu.3 uc292ceu.1 uc292ceu.2 uc292ceu.3 
ENSMUST00000180617.2 A630072L19Rik ENSMUST00000180617.2 A630072L19Rik (from geneSymbol) AK153749 ENSMUST00000180617.1 uc288irq.1 uc288irq.2 uc288irq.1 uc288irq.2 
ENSMUST00000180623.3 Gm2061 ENSMUST00000180623.3 predicted gene 2061 (from RefSeq NR_040305.1) ENSMUST00000180623.1 ENSMUST00000180623.2 NR_040305 uc007dzj.1 uc007dzj.2 uc007dzj.3 uc007dzj.1 uc007dzj.2 uc007dzj.3 
ENSMUST00000180627.2 Gm26897 ENSMUST00000180627.2 Gm26897 (from geneSymbol) ENSMUST00000180627.1 Gm26897 M0QWX3 M0QWX3_MOUSE uc290yib.1 uc290yib.2 uc290yib.1 uc290yib.2 
ENSMUST00000180630.3 Gm26532 ENSMUST00000180630.3 Gm26532 (from geneSymbol) DL243127 ENSMUST00000180630.1 ENSMUST00000180630.2 uc292bnc.1 uc292bnc.2 uc292bnc.3 uc292bnc.1 uc292bnc.2 uc292bnc.3 
ENSMUST00000180634.3 4930467D21Rik ENSMUST00000180634.3 4930467D21Rik (from geneSymbol) AK133367 ENSMUST00000180634.1 ENSMUST00000180634.2 uc012dzk.1 uc012dzk.2 uc012dzk.3 uc012dzk.4 uc012dzk.5 uc012dzk.1 uc012dzk.2 uc012dzk.3 uc012dzk.4 uc012dzk.5 
ENSMUST00000180638.5 3110045C21Rik ENSMUST00000180638.5 3110045C21Rik (from geneSymbol) AK014177 ENSMUST00000180638.1 ENSMUST00000180638.2 ENSMUST00000180638.3 ENSMUST00000180638.4 uc007dls.1 uc007dls.2 uc007dls.3 uc007dls.4 uc007dls.5 uc007dls.1 uc007dls.2 uc007dls.3 uc007dls.4 uc007dls.5 
ENSMUST00000180645.2 Gm26556 ENSMUST00000180645.2 Gm26556 (from geneSymbol) ENSMUST00000180645.1 uc291cjg.1 uc291cjg.2 uc291cjg.1 uc291cjg.2 
ENSMUST00000180650.3 Gm26761 ENSMUST00000180650.3 Gm26761 (from geneSymbol) AK033648 ENSMUST00000180650.1 ENSMUST00000180650.2 uc290vtv.1 uc290vtv.2 uc290vtv.1 uc290vtv.2 
ENSMUST00000180653.3 Platr31 ENSMUST00000180653.3 Platr31 (from geneSymbol) AK139647 ENSMUST00000180653.1 ENSMUST00000180653.2 uc291jdc.1 uc291jdc.2 uc291jdc.1 uc291jdc.2 
ENSMUST00000180668.2 Gm2670 ENSMUST00000180668.2 Gm2670 (from geneSymbol) AK080926 ENSMUST00000180668.1 uc288rtw.1 uc288rtw.2 uc288rtw.1 uc288rtw.2 
ENSMUST00000180670.4 Gm10687 ENSMUST00000180670.4 predicted gene 10687 (from RefSeq NR_152189.1) ENSMUST00000180670.1 ENSMUST00000180670.2 ENSMUST00000180670.3 NR_152189 uc292gme.1 uc292gme.2 uc292gme.3 uc292gme.1 uc292gme.2 uc292gme.3 
ENSMUST00000180673.2 Zfa-ps ENSMUST00000180673.2 zinc finger protein, autosomal, pseudogene (from RefSeq NR_037920.1) ENSMUST00000180673.1 NR_037920 uc029qxe.1 uc029qxe.2 uc029qxe.3 uc029qxe.1 uc029qxe.2 uc029qxe.3 
ENSMUST00000180677.2 1190005I06Rik ENSMUST00000180677.2 1190005I06Rik (from geneSymbol) 1190005I06Rik A0A6Q6RNR6 A0A6Q6RNR6_MOUSE AK004494 ENSMUST00000180677.1 uc292dnx.1 uc292dnx.2 uc292dnx.1 uc292dnx.2 
ENSMUST00000180680.2 Gm26577 ENSMUST00000180680.2 Gm26577 (from geneSymbol) AK138601 ENSMUST00000180680.1 uc287pxv.1 uc287pxv.2 uc287pxv.1 uc287pxv.2 
ENSMUST00000180686.3 Gm26839 ENSMUST00000180686.3 Gm26839 (from geneSymbol) AK131831 ENSMUST00000180686.1 ENSMUST00000180686.2 uc007orz.1 uc007orz.2 uc007orz.3 uc007orz.1 uc007orz.2 uc007orz.3 
ENSMUST00000180687.3 Trav6d-5 ENSMUST00000180687.3 Trav6d-5 (from geneSymbol) A0A075B6B9 A0A075B6B9_MOUSE ENSMUST00000180687.1 ENSMUST00000180687.2 Trav6d-5 uc288twu.1 uc288twu.2 immunoglobulin production extracellular space immune response uc288twu.1 uc288twu.2 
ENSMUST00000180691.3 Gm26852 ENSMUST00000180691.3 Gm26852 (from geneSymbol) ENSMUST00000180691.1 ENSMUST00000180691.2 uc291mjo.1 uc291mjo.2 uc291mjo.1 uc291mjo.2 
ENSMUST00000180693.8 5830432E09Rik ENSMUST00000180693.8 5830432E09Rik (from geneSymbol) AK148045 ENSMUST00000180693.1 ENSMUST00000180693.2 ENSMUST00000180693.3 ENSMUST00000180693.4 ENSMUST00000180693.5 ENSMUST00000180693.6 ENSMUST00000180693.7 uc009keh.1 uc009keh.2 uc009keh.1 uc009keh.2 
ENSMUST00000180695.3 4732414G09Rik ENSMUST00000180695.3 4732414G09Rik (from geneSymbol) AK076313 ENSMUST00000180695.1 ENSMUST00000180695.2 uc287zye.1 uc287zye.2 uc287zye.3 uc287zye.1 uc287zye.2 uc287zye.3 
ENSMUST00000180699.2 Gm26550 ENSMUST00000180699.2 Gm26550 (from geneSymbol) AK136710 ENSMUST00000180699.1 uc291mvk.1 uc291mvk.2 uc291mvk.1 uc291mvk.2 
ENSMUST00000180708.4 4932441J04Rik ENSMUST00000180708.4 RIKEN cDNA 4932441J04 gene (from RefSeq NR_015588.2) ENSMUST00000180708.1 ENSMUST00000180708.2 ENSMUST00000180708.3 NR_015588 uc008xls.1 uc008xls.2 uc008xls.3 uc008xls.4 uc008xls.1 uc008xls.2 uc008xls.3 uc008xls.4 
ENSMUST00000180711.3 Trav6-4 ENSMUST00000180711.3 Trav6-4 (from geneSymbol) A0A075B6B4 A0A075B6B4_MOUSE ENSMUST00000180711.1 ENSMUST00000180711.2 Trav6-4 U07658 uc007tse.1 uc007tse.2 uc007tse.3 uc007tse.4 uc007tse.5 immunoglobulin production extracellular space immune response uc007tse.1 uc007tse.2 uc007tse.3 uc007tse.4 uc007tse.5 
ENSMUST00000180715.3 Gm26646 ENSMUST00000180715.3 Gm26646 (from geneSymbol) ENSMUST00000180715.1 ENSMUST00000180715.2 uc291rsl.1 uc291rsl.2 uc291rsl.1 uc291rsl.2 
ENSMUST00000180717.3 Trav6d-4 ENSMUST00000180717.3 Trav6d-4 (from geneSymbol) ENSMUST00000180717.1 ENSMUST00000180717.2 Q5R1I0 Q5R1I0_MOUSE TRAV6D-4 Trav6d-4 uc288twp.1 uc288twp.2 immunoglobulin production molecular_function extracellular space immune response uc288twp.1 uc288twp.2 
ENSMUST00000180719.3 Gm26520 ENSMUST00000180719.3 predicted gene, 26520 (from RefSeq NR_166882.1) ENSMUST00000180719.1 ENSMUST00000180719.2 NR_166882 uc288enl.1 uc288enl.2 uc288enl.3 uc288enl.1 uc288enl.2 uc288enl.3 
ENSMUST00000180726.3 ENSMUSG00000121883 ENSMUST00000180726.3 ENSMUSG00000121883 (from geneSymbol) AK045260 ENSMUST00000180726.1 ENSMUST00000180726.2 uc287pzj.1 uc287pzj.2 uc287pzj.3 uc287pzj.1 uc287pzj.2 uc287pzj.3 
ENSMUST00000180727.8 Gm16794 ENSMUST00000180727.8 Gm16794 (from geneSymbol) AK040392 ENSMUST00000180727.1 ENSMUST00000180727.2 ENSMUST00000180727.3 ENSMUST00000180727.4 ENSMUST00000180727.5 ENSMUST00000180727.6 ENSMUST00000180727.7 uc009rbt.1 uc009rbt.2 uc009rbt.3 uc009rbt.1 uc009rbt.2 uc009rbt.3 
ENSMUST00000180729.2 Gm26543 ENSMUST00000180729.2 Gm26543 (from geneSymbol) AK043485 ENSMUST00000180729.1 uc287ray.1 uc287ray.2 uc287ray.1 uc287ray.2 
ENSMUST00000180731.2 Platr6 ENSMUST00000180731.2 Platr6 (from geneSymbol) AK049156 ENSMUST00000180731.1 uc287pyt.1 uc287pyt.2 uc287pyt.1 uc287pyt.2 
ENSMUST00000180735.4 D930030I03Rik ENSMUST00000180735.4 D930030I03Rik (from geneSymbol) AK086460 ENSMUST00000180735.1 ENSMUST00000180735.2 ENSMUST00000180735.3 uc007zey.1 uc007zey.2 uc007zey.3 uc007zey.4 uc007zey.1 uc007zey.2 uc007zey.3 uc007zey.4 
ENSMUST00000180738.3 Gm17529 ENSMUST00000180738.3 Gm17529 (from geneSymbol) AK044650 ENSMUST00000180738.1 ENSMUST00000180738.2 uc288gnz.1 uc288gnz.2 uc288gnz.1 uc288gnz.2 
ENSMUST00000180746.2 Tdpoz9 ENSMUST00000180746.2 TD and POZ domain containing 9 (from RefSeq NM_001163730.2) ENSMUST00000180746.1 Gm9125 NM_001163730 P0DMR6 Q717B3 Q71G58 Q8BZV7 Q8VI39 TDP1L_MOUSE uc008qfq.1 uc008qfq.2 Belongs to the Tdpoz family. nucleus cytoplasm ubiquitin-dependent protein catabolic process regulation of proteolysis ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process uc008qfq.1 uc008qfq.2 
ENSMUST00000180749.2 Gm26903 ENSMUST00000180749.2 Gm26903 (from geneSymbol) AK079078 ENSMUST00000180749.1 uc292iwu.1 uc292iwu.2 uc292iwu.1 uc292iwu.2 
ENSMUST00000180752.3 Gm16973 ENSMUST00000180752.3 predicted gene, 16973, transcript variant 2 (from RefSeq NR_046210.1) ENSMUST00000180752.1 ENSMUST00000180752.2 NR_046210 uc288utz.1 uc288utz.2 uc288utz.3 uc288utz.1 uc288utz.2 uc288utz.3 
ENSMUST00000180753.2 Gm2366 ENSMUST00000180753.2 Gm2366 (from geneSymbol) AK077006 ENSMUST00000180753.1 uc009lol.1 uc009lol.2 uc009lol.1 uc009lol.2 
ENSMUST00000180759.2 Gm5432 ENSMUST00000180759.2 Gm5432 (from geneSymbol) AK045700 ENSMUST00000180759.1 uc007nbr.1 uc007nbr.2 uc007nbr.1 uc007nbr.2 
ENSMUST00000180764.3 Gm26820 ENSMUST00000180764.3 Gm26820 (from geneSymbol) AK136331 ENSMUST00000180764.1 ENSMUST00000180764.2 uc290jwg.1 uc290jwg.2 uc290jwg.1 uc290jwg.2 
ENSMUST00000180765.2 Nudt22 ENSMUST00000180765.2 Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose. (from UniProt Q9DD16) AK002252 ENSMUST00000180765.1 NUD22_MOUSE Q8VCI4 Q9DD16 uc289qpf.1 uc289qpf.2 Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose. Reaction=UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.; EC=3.6.1.45; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the Nudix hydrolase family. nucleoplasm biological_process UDP-sugar diphosphatase activity hydrolase activity metal ion binding GDP-mannose hydrolase activity uc289qpf.1 uc289qpf.2 
ENSMUST00000180768.2 Tcstv5a ENSMUST00000180768.2 Tcstv family member 5 (from RefSeq NM_001033769.2) B020031M17Rik ENSMUST00000180768.1 NM_001033769 Q3UT11 Q3UT11_MOUSE uc029sdq.1 uc029sdq.2 molecular_function cellular_component biological_process uc029sdq.1 uc029sdq.2 
ENSMUST00000180770.3 Gm26674 ENSMUST00000180770.3 Gm26674 (from geneSymbol) AK010852 ENSMUST00000180770.1 ENSMUST00000180770.2 uc287pkz.1 uc287pkz.2 uc287pkz.1 uc287pkz.2 
ENSMUST00000180778.2 Gm26813 ENSMUST00000180778.2 Gm26813 (from geneSymbol) AK036739 ENSMUST00000180778.1 uc287ils.1 uc287ils.2 uc287ils.1 uc287ils.2 
ENSMUST00000180785.3 Gm26612 ENSMUST00000180785.3 Gm26612 (from geneSymbol) AK041553 ENSMUST00000180785.1 ENSMUST00000180785.2 uc289nke.1 uc289nke.2 uc289nke.3 uc289nke.1 uc289nke.2 uc289nke.3 
ENSMUST00000180787.3 Pnma6e ENSMUST00000180787.3 PNMA family member 6E (from RefSeq NM_001419142.1) A0A140LIU8 A0A140LIU8_MOUSE ENSMUST00000180787.1 ENSMUST00000180787.2 Gm18336 NM_001419142 Pnma6e uc292oqz.1 uc292oqz.2 Belongs to the PNMA family. uc292oqz.1 uc292oqz.2 
ENSMUST00000180788.8 Gm8246 ENSMUST00000180788.8 Gm8246 (from geneSymbol) ENSMUST00000180788.1 ENSMUST00000180788.2 ENSMUST00000180788.3 ENSMUST00000180788.4 ENSMUST00000180788.5 ENSMUST00000180788.6 ENSMUST00000180788.7 Gm8246 M0QWX9 M0QWX9_MOUSE uc288qmc.1 uc288qmc.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288qmc.1 uc288qmc.2 
ENSMUST00000180791.2 4731419I09Rik ENSMUST00000180791.2 4731419I09Rik (from geneSymbol) AK132440 ENSMUST00000180791.1 uc008pyt.1 uc008pyt.2 uc008pyt.3 uc008pyt.4 uc008pyt.1 uc008pyt.2 uc008pyt.3 uc008pyt.4 
ENSMUST00000180792.8 Snx29 ENSMUST00000180792.8 sorting nexin 29, transcript variant 1 (from RefSeq NM_028964.5) ENSMUST00000180792.1 ENSMUST00000180792.2 ENSMUST00000180792.3 ENSMUST00000180792.4 ENSMUST00000180792.5 ENSMUST00000180792.6 ENSMUST00000180792.7 NM_028964 Q8K050 Q9D3S3 SNX29_MOUSE uc029swd.1 uc029swd.2 uc029swd.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D3S3-1; Sequence=Displayed; Name=2; IsoId=Q9D3S3-3; Sequence=VSP_041966; Belongs to the sorting nexin family. Sequence=AAH34114.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; molecular_function biological_process phosphatidylinositol binding uc029swd.1 uc029swd.2 uc029swd.3 
ENSMUST00000180797.3 Platr23 ENSMUST00000180797.3 Platr23 (from geneSymbol) AK144512 ENSMUST00000180797.1 ENSMUST00000180797.2 uc057kgu.1 uc057kgu.2 uc057kgu.3 uc057kgu.1 uc057kgu.2 uc057kgu.3 
ENSMUST00000180800.2 D130020L05Rik ENSMUST00000180800.2 RIKEN cDNA D130020L05 gene, transcript variant 4 (from RefSeq NR_038050.1) ENSMUST00000180800.1 NR_038050 uc011yqf.1 uc011yqf.2 uc011yqf.3 uc011yqf.4 uc011yqf.1 uc011yqf.2 uc011yqf.3 uc011yqf.4 
ENSMUST00000180801.3 Gm26554 ENSMUST00000180801.3 Gm26554 (from geneSymbol) AK079843 ENSMUST00000180801.1 ENSMUST00000180801.2 uc291nrt.1 uc291nrt.2 uc291nrt.1 uc291nrt.2 
ENSMUST00000180802.3 Gm20109 ENSMUST00000180802.3 Gm20109 (from geneSymbol) AK146407 ENSMUST00000180802.1 ENSMUST00000180802.2 uc008brb.1 uc008brb.2 uc008brb.3 uc008brb.4 uc008brb.1 uc008brb.2 uc008brb.3 uc008brb.4 
ENSMUST00000180807.3 Gm26861 ENSMUST00000180807.3 Gm26861 (from geneSymbol) AK132017 ENSMUST00000180807.1 ENSMUST00000180807.2 uc288kqu.1 uc288kqu.2 uc288kqu.1 uc288kqu.2 
ENSMUST00000180812.3 Gm10390 ENSMUST00000180812.3 predicted gene 10390 (from RefSeq NR_045793.1) ENSMUST00000180812.1 ENSMUST00000180812.2 NR_045793 uc008zhb.1 uc008zhb.2 uc008zhb.3 uc008zhb.1 uc008zhb.2 uc008zhb.3 
ENSMUST00000180816.2 Gm26647 ENSMUST00000180816.2 Gm26647 (from geneSymbol) AK038577 ENSMUST00000180816.1 uc290uxo.1 uc290uxo.2 uc290uxo.1 uc290uxo.2 
ENSMUST00000180831.4 4930467K11Rik ENSMUST00000180831.4 RIKEN cDNA 4930467K11 gene (from RefSeq NR_045353.1) ENSMUST00000180831.1 ENSMUST00000180831.2 ENSMUST00000180831.3 NR_045353 uc029qxg.1 uc029qxg.2 uc029qxg.3 uc029qxg.4 uc029qxg.1 uc029qxg.2 uc029qxg.3 uc029qxg.4 
ENSMUST00000180837.3 9330185C12Rik ENSMUST00000180837.3 9330185C12Rik (from geneSymbol) AK020392 ENSMUST00000180837.1 ENSMUST00000180837.2 uc287lag.1 uc287lag.2 uc287lag.3 uc287lag.1 uc287lag.2 uc287lag.3 
ENSMUST00000180839.4 Gm17276 ENSMUST00000180839.4 Gm17276 (from geneSymbol) BC048393 ENSMUST00000180839.1 ENSMUST00000180839.2 ENSMUST00000180839.3 uc008bvw.1 uc008bvw.2 uc008bvw.3 uc008bvw.4 uc008bvw.5 uc008bvw.6 uc008bvw.1 uc008bvw.2 uc008bvw.3 uc008bvw.4 uc008bvw.5 uc008bvw.6 
ENSMUST00000180842.2 9330136K24Rik ENSMUST00000180842.2 RIKEN cDNA 9330136K24 gene (from RefSeq NR_131123.1) ENSMUST00000180842.1 NR_131123 uc056zdl.1 uc056zdl.2 uc056zdl.3 uc056zdl.1 uc056zdl.2 uc056zdl.3 
ENSMUST00000180848.2 Gm26629 ENSMUST00000180848.2 predicted gene, 26629 (from RefSeq NR_166832.1) ENSMUST00000180848.1 NR_166832 uc289siw.1 uc289siw.2 uc289siw.1 uc289siw.2 
ENSMUST00000180852.2 2610037D02Rik ENSMUST00000180852.2 2610037D02Rik (from geneSymbol) AK163711 ENSMUST00000180852.1 uc007xjz.1 uc007xjz.2 uc007xjz.1 uc007xjz.2 
ENSMUST00000180853.2 B430219N15Rik ENSMUST00000180853.2 B430219N15Rik (from geneSymbol) AK046650 ENSMUST00000180853.1 uc287pkf.1 uc287pkf.2 uc287pkf.1 uc287pkf.2 
ENSMUST00000180858.4 D630011A20Rik ENSMUST00000180858.4 D630011A20Rik (from geneSymbol) AK085316 ENSMUST00000180858.1 ENSMUST00000180858.2 ENSMUST00000180858.3 uc009kwb.1 uc009kwb.2 uc009kwb.3 uc009kwb.4 uc009kwb.1 uc009kwb.2 uc009kwb.3 uc009kwb.4 
ENSMUST00000180860.4 Gm6277 ENSMUST00000180860.4 predicted gene 6277 (from RefSeq NR_045421.1) ENSMUST00000180860.1 ENSMUST00000180860.2 ENSMUST00000180860.3 NR_045421 uc008ebq.1 uc008ebq.2 uc008ebq.3 uc008ebq.4 uc008ebq.1 uc008ebq.2 uc008ebq.3 uc008ebq.4 
ENSMUST00000180862.3 Gm26872 ENSMUST00000180862.3 Gm26872 (from geneSymbol) AK047605 ENSMUST00000180862.1 ENSMUST00000180862.2 uc290xts.1 uc290xts.2 uc290xts.1 uc290xts.2 
ENSMUST00000180865.3 Gm9917 ENSMUST00000180865.3 predicted gene 9917 (from RefSeq NR_166687.1) ENSMUST00000180865.1 ENSMUST00000180865.2 NR_166687 uc012hah.1 uc012hah.2 uc012hah.3 uc012hah.1 uc012hah.2 uc012hah.3 
ENSMUST00000180867.8 Gm3194 ENSMUST00000180867.8 Gm3194 (from geneSymbol) A6NAS6 A6NAS6_MOUSE BC040090 ENSMUST00000180867.1 ENSMUST00000180867.2 ENSMUST00000180867.3 ENSMUST00000180867.4 ENSMUST00000180867.5 ENSMUST00000180867.6 ENSMUST00000180867.7 Gm3194 Gm3383 uc288qmb.1 uc288qmb.2 uc288qmb.1 uc288qmb.2 
ENSMUST00000180870.3 Gm26592 ENSMUST00000180870.3 predicted gene, 26592 (from RefSeq NR_188922.1) ENSMUST00000180870.1 ENSMUST00000180870.2 NR_188922 uc292eyy.1 uc292eyy.2 uc292eyy.3 uc292eyy.1 uc292eyy.2 uc292eyy.3 
ENSMUST00000180875.3 Gm26876 ENSMUST00000180875.3 predicted gene, 26876 (from RefSeq NR_152728.1) ENSMUST00000180875.1 ENSMUST00000180875.2 NR_152728 uc007hnr.1 uc007hnr.2 uc007hnr.3 uc007hnr.1 uc007hnr.2 uc007hnr.3 
ENSMUST00000180878.8 9530036O11Rik ENSMUST00000180878.8 9530036O11Rik (from geneSymbol) AK053224 ENSMUST00000180878.1 ENSMUST00000180878.2 ENSMUST00000180878.3 ENSMUST00000180878.4 ENSMUST00000180878.5 ENSMUST00000180878.6 ENSMUST00000180878.7 uc008wub.1 uc008wub.2 uc008wub.1 uc008wub.2 
ENSMUST00000180882.8 Gm26555 ENSMUST00000180882.8 Gm26555 (from geneSymbol) AK029615 ENSMUST00000180882.1 ENSMUST00000180882.2 ENSMUST00000180882.3 ENSMUST00000180882.4 ENSMUST00000180882.5 ENSMUST00000180882.6 ENSMUST00000180882.7 uc288nfq.1 uc288nfq.2 uc288nfq.1 uc288nfq.2 
ENSMUST00000180889.8 Alyreffm17 ENSMUST00000180889.8 predicted gene, 21312 (from RefSeq NM_001270642.1) ENSMUST00000180889.1 ENSMUST00000180889.2 ENSMUST00000180889.3 ENSMUST00000180889.4 ENSMUST00000180889.5 ENSMUST00000180889.6 ENSMUST00000180889.7 Gm20765 Gm21293 Gm21304 Gm21312 Gm6763 Gm8764 M0QWB2 M0QWR4 M0QWR4_MOUSE NM_001270642 uc057kju.1 uc057kju.2 uc057kju.3 nucleic acid binding RNA binding uc057kju.1 uc057kju.2 uc057kju.3 
ENSMUST00000180899.2 Gm26833 ENSMUST00000180899.2 Gm26833 (from geneSymbol) AB346974 ENSMUST00000180899.1 uc291dsk.1 uc291dsk.2 uc291dsk.1 uc291dsk.2 
ENSMUST00000180904.2 Gm10556 ENSMUST00000180904.2 predicted gene 10556 (from RefSeq NR_045881.1) ENSMUST00000180904.1 NR_045881 uc029tln.1 uc029tln.2 uc029tln.1 uc029tln.2 
ENSMUST00000180913.2 Gm26743 ENSMUST00000180913.2 Gm26743 (from geneSymbol) AK136608 ENSMUST00000180913.1 uc289woq.1 uc289woq.2 uc289woq.1 uc289woq.2 
ENSMUST00000180921.2 Gm49291 ENSMUST00000180921.2 RIKEN cDNA A330033J07 gene (from RefSeq NR_102303.1) ENSMUST00000180921.1 NR_102303 uc007qib.1 uc007qib.2 uc007qib.1 uc007qib.2 
ENSMUST00000180926.3 Gm26604 ENSMUST00000180926.3 Gm26604 (from geneSymbol) AK048019 ENSMUST00000180926.1 ENSMUST00000180926.2 uc009gaq.1 uc009gaq.2 uc009gaq.3 uc009gaq.1 uc009gaq.2 uc009gaq.3 
ENSMUST00000180930.2 Gm26793 ENSMUST00000180930.2 Gm26793 (from geneSymbol) AK050685 ENSMUST00000180930.1 uc291xqu.1 uc291xqu.2 uc291xqu.1 uc291xqu.2 
ENSMUST00000180933.4 9030407P20Rik ENSMUST00000180933.4 9030407P20Rik (from geneSymbol) AK034016 ENSMUST00000180933.1 ENSMUST00000180933.2 ENSMUST00000180933.3 uc009jmv.1 uc009jmv.2 uc009jmv.3 uc009jmv.4 uc009jmv.1 uc009jmv.2 uc009jmv.3 uc009jmv.4 
ENSMUST00000180937.3 1700026J14Rik ENSMUST00000180937.3 1700026J14Rik (from geneSymbol) AK006390 ENSMUST00000180937.1 ENSMUST00000180937.2 uc057ada.1 uc057ada.2 uc057ada.3 uc057ada.1 uc057ada.2 uc057ada.3 
ENSMUST00000180938.3 Trav21-dv12 ENSMUST00000180938.3 Trav21-dv12 (from geneSymbol) A0A075B6C4 A0A075B6C4_MOUSE ENSMUST00000180938.1 ENSMUST00000180938.2 Trav21-dv12 X02934 uc288ubi.1 uc288ubi.2 uc288ubi.1 uc288ubi.2 
ENSMUST00000180941.3 2310026I22Rik ENSMUST00000180941.3 2310026I22Rik (from geneSymbol) AK009506 ENSMUST00000180941.1 ENSMUST00000180941.2 uc289oox.1 uc289oox.2 uc289oox.1 uc289oox.2 
ENSMUST00000180944.8 Gm26680 ENSMUST00000180944.8 Gm26680 (from geneSymbol) AK015236 ENSMUST00000180944.1 ENSMUST00000180944.2 ENSMUST00000180944.3 ENSMUST00000180944.4 ENSMUST00000180944.5 ENSMUST00000180944.6 ENSMUST00000180944.7 uc288qoz.1 uc288qoz.2 uc288qoz.1 uc288qoz.2 
ENSMUST00000180948.2 4930563E18Rik ENSMUST00000180948.2 RIKEN cDNA 4930563E18 gene (from RefSeq NR_045379.1) ENSMUST00000180948.1 NR_045379 uc029tlr.1 uc029tlr.2 uc029tlr.1 uc029tlr.2 
ENSMUST00000180953.2 5330439K02Rik ENSMUST00000180953.2 5330439K02Rik (from geneSymbol) ENSMUST00000180953.1 KY467740 uc057kut.1 uc057kut.2 uc057kut.1 uc057kut.2 
ENSMUST00000180957.3 1700034B16Rik ENSMUST00000180957.3 1700034B16Rik (from geneSymbol) AK006590 ENSMUST00000180957.1 ENSMUST00000180957.2 uc289pqx.1 uc289pqx.2 uc289pqx.3 uc289pqx.1 uc289pqx.2 uc289pqx.3 
ENSMUST00000180970.3 Gm26865 ENSMUST00000180970.3 Gm26865 (from geneSymbol) AK132393 ENSMUST00000180970.1 ENSMUST00000180970.2 uc289nqp.1 uc289nqp.2 uc289nqp.1 uc289nqp.2 
ENSMUST00000180972.3 Trav12-2 ENSMUST00000180972.3 Trav12-2 (from geneSymbol) A0N8N6 A0N8N6_MOUSE AK050608 ENSMUST00000180972.1 ENSMUST00000180972.2 Trav12-2 uc288uap.1 uc288uap.2 immunoglobulin production molecular_function extracellular space immune response uc288uap.1 uc288uap.2 
ENSMUST00000180981.2 Gm26642 ENSMUST00000180981.2 Gm26642 (from geneSymbol) AK133325 ENSMUST00000180981.1 uc287lyw.1 uc287lyw.2 uc287lyw.1 uc287lyw.2 
ENSMUST00000180988.2 Gm26912 ENSMUST00000180988.2 Gm26912 (from geneSymbol) AK141469 ENSMUST00000180988.1 uc288jhr.1 uc288jhr.2 uc288jhr.1 uc288jhr.2 
ENSMUST00000180989.4 Gm26626 ENSMUST00000180989.4 predicted gene, 26626 (from RefSeq NR_188888.1) ENSMUST00000180989.1 ENSMUST00000180989.2 ENSMUST00000180989.3 NR_188888 uc289ger.1 uc289ger.2 uc289ger.1 uc289ger.2 
ENSMUST00000180997.4 BC065403 ENSMUST00000180997.4 BC065403 (from geneSymbol) AK020810 ENSMUST00000180997.1 ENSMUST00000180997.2 ENSMUST00000180997.3 uc292ipy.1 uc292ipy.2 uc292ipy.3 uc292ipy.1 uc292ipy.2 uc292ipy.3 
ENSMUST00000181001.8 Obox1 ENSMUST00000181001.8 Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Together with other Obox family members, required in early two-cell stage embryos to kick-start the major ZGA wave by facilitating RNA Polymerase II 'pre-configuration', during which RNA Polymerase II relocates from the initial one-cell stage binding targets to ZGA gene promoters and distal enhancers (PubMed:37459895). Mechanistically, promotes recruitment of RNA Polymerase II from (CG-rich) non-ZGA genes to (CG-poor) ZGA genes at the two-cell stage (PubMed:37459895). Binds to regulatory DNA sequences containing a 5'-ACNCCTTTAATCCCAG-3' sequence motif (PubMed:37459895). Most maternal and zygotic Obox family proteins can compensate for one another (PubMed:37459895). In addition to its role in ZGA, promotes embryonic stem cell pluripotency (PubMed:29033306). (from UniProt Q9D350) AK018362 ENSMUST00000181001.1 ENSMUST00000181001.2 ENSMUST00000181001.3 ENSMUST00000181001.4 ENSMUST00000181001.5 ENSMUST00000181001.6 ENSMUST00000181001.7 G3UX03 OBOX1_MOUSE Obox1 Q9D350 uc291lxe.1 uc291lxe.2 Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Together with other Obox family members, required in early two-cell stage embryos to kick-start the major ZGA wave by facilitating RNA Polymerase II 'pre-configuration', during which RNA Polymerase II relocates from the initial one-cell stage binding targets to ZGA gene promoters and distal enhancers (PubMed:37459895). Mechanistically, promotes recruitment of RNA Polymerase II from (CG-rich) non-ZGA genes to (CG-poor) ZGA genes at the two-cell stage (PubMed:37459895). Binds to regulatory DNA sequences containing a 5'-ACNCCTTTAATCCCAG-3' sequence motif (PubMed:37459895). Most maternal and zygotic Obox family proteins can compensate for one another (PubMed:37459895). In addition to its role in ZGA, promotes embryonic stem cell pluripotency (PubMed:29033306). Nucleus Specifically expressed in oocytes and early embryos. Expressed maternally with high expression in oocytes and early embryos before expression declines after zygotic genome activation (ZGA). No visible phenotype; mice are viable and fertile (PubMed:37459895). Female mice lacking maternally transcribed Obox1, Obox2, Obox5, Obox7 as well as zygotically expressed Obox3 and Obox4 are infertile: embryos arrest at two-four cell stage due to impaired zygotic genome activation (ZGA) (PubMed:37459895). Belongs to the paired homeobox family. Obox subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding uc291lxe.1 uc291lxe.2 
ENSMUST00000181005.2 4632411P08Rik ENSMUST00000181005.2 4632411P08Rik (from geneSymbol) AK019492 ENSMUST00000181005.1 uc057llq.1 uc057llq.2 uc057llq.1 uc057llq.2 
ENSMUST00000181008.3 Gm16617 ENSMUST00000181008.3 predicted gene, 16617 (from RefSeq NR_045728.1) ENSMUST00000181008.1 ENSMUST00000181008.2 NR_045728 uc029sjc.1 uc029sjc.2 uc029sjc.3 uc029sjc.1 uc029sjc.2 uc029sjc.3 
ENSMUST00000181014.8 D330041H03Rik ENSMUST00000181014.8 D330041H03Rik (from geneSymbol) AK038021 ENSMUST00000181014.1 ENSMUST00000181014.2 ENSMUST00000181014.3 ENSMUST00000181014.4 ENSMUST00000181014.5 ENSMUST00000181014.6 ENSMUST00000181014.7 uc008avq.1 uc008avq.2 uc008avq.3 uc008avq.1 uc008avq.2 uc008avq.3 
ENSMUST00000181016.3 Platr5 ENSMUST00000181016.3 pluripotency associated transcript 5 (from RefSeq NR_040493.1) ENSMUST00000181016.1 ENSMUST00000181016.2 NR_040493 uc007byu.1 uc007byu.2 uc007byu.3 uc007byu.1 uc007byu.2 uc007byu.3 
ENSMUST00000181018.3 Gm26576 ENSMUST00000181018.3 Gm26576 (from geneSymbol) AK052180 ENSMUST00000181018.1 ENSMUST00000181018.2 uc287ruy.1 uc287ruy.2 uc287ruy.1 uc287ruy.2 
ENSMUST00000181021.2 AI849053 ENSMUST00000181021.2 AI849053 (from geneSymbol) ENSMUST00000181021.1 uc290glp.1 uc290glp.2 uc290glp.1 uc290glp.2 
ENSMUST00000181029.5 E230001N04Rik ENSMUST00000181029.5 E230001N04Rik (from geneSymbol) AK153588 ENSMUST00000181029.1 ENSMUST00000181029.2 ENSMUST00000181029.3 ENSMUST00000181029.4 uc008brc.1 uc008brc.2 uc008brc.3 uc008brc.4 uc008brc.5 uc008brc.1 uc008brc.2 uc008brc.3 uc008brc.4 uc008brc.5 
ENSMUST00000181032.3 A930029G22Rik ENSMUST00000181032.3 A930029G22Rik (from geneSymbol) AK044644 ENSMUST00000181032.1 ENSMUST00000181032.2 uc008dkv.1 uc008dkv.2 uc008dkv.3 uc008dkv.1 uc008dkv.2 uc008dkv.3 
ENSMUST00000181033.8 Gm26552 ENSMUST00000181033.8 Gm26552 (from geneSymbol) AK015236 ENSMUST00000181033.1 ENSMUST00000181033.2 ENSMUST00000181033.3 ENSMUST00000181033.4 ENSMUST00000181033.5 ENSMUST00000181033.6 ENSMUST00000181033.7 uc288qln.1 uc288qln.2 uc288qln.1 uc288qln.2 
ENSMUST00000181035.2 ENSMUSG00000121718 ENSMUST00000181035.2 ENSMUSG00000121718 (from geneSymbol) ENSMUST00000181035.1 uc287hjc.1 uc287hjc.2 uc287hjc.1 uc287hjc.2 
ENSMUST00000181038.3 Trav14d-1 ENSMUST00000181038.3 Trav14d-1 (from geneSymbol) A0A075B6B1 A0A075B6B1_MOUSE AK039793 ENSMUST00000181038.1 ENSMUST00000181038.2 Trav14d-1 Trav14n-1 uc288twz.1 uc288twz.2 uc288twz.1 uc288twz.2 
ENSMUST00000181039.8 Jsrp1 ENSMUST00000181039.8 junctional sarcoplasmic reticulum protein 1 (from RefSeq NM_028001.3) ENSMUST00000181039.1 ENSMUST00000181039.2 ENSMUST00000181039.3 ENSMUST00000181039.4 ENSMUST00000181039.5 ENSMUST00000181039.6 ENSMUST00000181039.7 Jsrp1 M0QW57 M0QW57_MOUSE NM_028001 uc007gev.1 uc007gev.2 uc007gev.3 uc007gev.4 skeletal muscle contraction uc007gev.1 uc007gev.2 uc007gev.3 uc007gev.4 
ENSMUST00000181041.2 Gm26739 ENSMUST00000181041.2 Gm26739 (from geneSymbol) ENSMUST00000181041.1 uc292dnw.1 uc292dnw.2 uc292dnw.1 uc292dnw.2 
ENSMUST00000181043.8 9330111N05Rik ENSMUST00000181043.8 9330111N05Rik (from geneSymbol) AK038818 ENSMUST00000181043.1 ENSMUST00000181043.2 ENSMUST00000181043.3 ENSMUST00000181043.4 ENSMUST00000181043.5 ENSMUST00000181043.6 ENSMUST00000181043.7 uc007rhl.1 uc007rhl.2 uc007rhl.3 uc007rhl.4 uc007rhl.1 uc007rhl.2 uc007rhl.3 uc007rhl.4 
ENSMUST00000181044.2 A930038B10Rik ENSMUST00000181044.2 A930038B10Rik (from geneSymbol) AK050096 ENSMUST00000181044.1 uc288ski.1 uc288ski.2 uc288ski.1 uc288ski.2 
ENSMUST00000181058.2 Gm5106 ENSMUST00000181058.2 predicted gene 5106, transcript variant 2 (from RefSeq NR_152133.1) ENSMUST00000181058.1 NR_152133 uc008wkn.1 uc008wkn.2 uc008wkn.1 uc008wkn.2 
ENSMUST00000181059.8 Alyreffm16 ENSMUST00000181059.8 predicted gene, 21304 (from RefSeq NM_001270901.1) ENSMUST00000181059.1 ENSMUST00000181059.2 ENSMUST00000181059.3 ENSMUST00000181059.4 ENSMUST00000181059.5 ENSMUST00000181059.6 ENSMUST00000181059.7 Gm20765 Gm21293 Gm21304 Gm21312 Gm6763 Gm8764 M0QWB2 M0QWR4 M0QWR4_MOUSE NM_001270901 uc057kjt.1 uc057kjt.2 uc057kjt.3 nucleic acid binding RNA binding uc057kjt.1 uc057kjt.2 uc057kjt.3 
ENSMUST00000181063.2 ENSMUSG00000121829 ENSMUST00000181063.2 ENSMUSG00000121829 (from geneSymbol) AK213341 ENSMUST00000181063.1 uc287whv.1 uc287whv.2 uc287whv.1 uc287whv.2 
ENSMUST00000181066.2 Gm26802 ENSMUST00000181066.2 Gm26802 (from geneSymbol) AK132834 ENSMUST00000181066.1 uc291miq.1 uc291miq.2 uc291miq.1 uc291miq.2 
ENSMUST00000181067.2 Gm26658 ENSMUST00000181067.2 Gm26658 (from geneSymbol) AK043527 ENSMUST00000181067.1 uc289omd.1 uc289omd.2 uc289omd.1 uc289omd.2 
ENSMUST00000181076.2 Gm26645 ENSMUST00000181076.2 Gm26645 (from geneSymbol) ENSMUST00000181076.1 uc288kyl.1 uc288kyl.2 uc288kyl.1 uc288kyl.2 
ENSMUST00000181083.6 9630001P10Rik ENSMUST00000181083.6 RIKEN cDNA 9630001P10 gene (from RefSeq NR_102378.1) ENSMUST00000181083.1 ENSMUST00000181083.2 ENSMUST00000181083.3 ENSMUST00000181083.4 ENSMUST00000181083.5 NR_102378 uc008xjc.1 uc008xjc.2 uc008xjc.3 uc008xjc.4 uc008xjc.1 uc008xjc.2 uc008xjc.3 uc008xjc.4 
ENSMUST00000181085.2 Gm10425 ENSMUST00000181085.2 Gm10425 (from geneSymbol) AK144938 ENSMUST00000181085.1 uc288jjl.1 uc288jjl.2 uc288jjl.1 uc288jjl.2 
ENSMUST00000181088.4 Or8b37 ENSMUST00000181088.4 Membrane ; Multi- pass membrane protein (from UniProt Q7TRE1) ENSMUST00000181088.1 ENSMUST00000181088.2 ENSMUST00000181088.3 Olfr884 Or8b37 Q7TRE1 Q7TRE1_MOUSE uc292fxa.1 uc292fxa.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fxa.1 uc292fxa.2 
ENSMUST00000181089.2 Gm26655 ENSMUST00000181089.2 Gm26655 (from geneSymbol) AK015236 ENSMUST00000181089.1 uc288qjy.1 uc288qjy.2 uc288qjy.1 uc288qjy.2 
ENSMUST00000181094.2 A930012L18Rik ENSMUST00000181094.2 RIKEN cDNA A930012L18 gene (from RefSeq NR_026853.1) ENSMUST00000181094.1 NR_026853 uc008eva.1 uc008eva.2 uc008eva.1 uc008eva.2 
ENSMUST00000181100.2 Raxos1 ENSMUST00000181100.2 Raxos1 (from geneSymbol) AK033044 ENSMUST00000181100.1 uc289pko.1 uc289pko.2 uc289pko.1 uc289pko.2 
ENSMUST00000181101.2 Gm26779 ENSMUST00000181101.2 Gm26779 (from geneSymbol) ENSMUST00000181101.1 uc290ycg.1 uc290ycg.2 uc290ycg.1 uc290ycg.2 
ENSMUST00000181102.2 Gm9903 ENSMUST00000181102.2 Gm9903 (from geneSymbol) AK040173 ENSMUST00000181102.1 uc008xau.1 uc008xau.2 uc008xau.3 uc008xau.1 uc008xau.2 uc008xau.3 
ENSMUST00000181103.3 Gm4211 ENSMUST00000181103.3 predicted gene 4211, transcript variant 1 (from RefSeq NR_175311.1) ENSMUST00000181103.1 ENSMUST00000181103.2 NR_175311 uc288our.1 uc288our.2 uc288our.3 uc288our.1 uc288our.2 uc288our.3 
ENSMUST00000181112.3 Gm26549 ENSMUST00000181112.3 Gm26549 (from geneSymbol) AK159351 ENSMUST00000181112.1 ENSMUST00000181112.2 uc289jqi.1 uc289jqi.2 uc289jqi.1 uc289jqi.2 
ENSMUST00000181120.2 Gm26632 ENSMUST00000181120.2 Gm26632 (from geneSymbol) AK033109 ENSMUST00000181120.1 uc291zge.1 uc291zge.2 uc291zge.1 uc291zge.2 
ENSMUST00000181126.2 Gm26673 ENSMUST00000181126.2 Gm26673 (from geneSymbol) AK031890 ENSMUST00000181126.1 uc291jce.1 uc291jce.2 uc291jce.1 uc291jce.2 
ENSMUST00000181128.4 1810019N24Rik ENSMUST00000181128.4 RIKEN cDNA 1810019N24 gene (from RefSeq NR_166501.1) ENSMUST00000181128.1 ENSMUST00000181128.2 ENSMUST00000181128.3 NR_166501 uc291lqj.1 uc291lqj.2 uc291lqj.3 uc291lqj.4 uc291lqj.1 uc291lqj.2 uc291lqj.3 uc291lqj.4 
ENSMUST00000181132.2 Gm26807 ENSMUST00000181132.2 Gm26807 (from geneSymbol) AK029208 ENSMUST00000181132.1 uc291dsp.1 uc291dsp.2 uc291dsp.1 uc291dsp.2 
ENSMUST00000181137.2 4930526L06Rik ENSMUST00000181137.2 RIKEN cDNA 4930526L06 gene (from RefSeq NR_045317.1) ENSMUST00000181137.1 NR_045317 uc029tri.1 uc029tri.2 uc029tri.3 uc029tri.1 uc029tri.2 uc029tri.3 
ENSMUST00000181143.3 B230104I21Rik ENSMUST00000181143.3 B230104I21Rik (from geneSymbol) AK140029 ENSMUST00000181143.1 ENSMUST00000181143.2 uc290sig.1 uc290sig.2 uc290sig.3 uc290sig.1 uc290sig.2 uc290sig.3 
ENSMUST00000181146.3 Gm26634 ENSMUST00000181146.3 Gm26634 (from geneSymbol) AK140680 ENSMUST00000181146.1 ENSMUST00000181146.2 uc288zmh.1 uc288zmh.2 uc288zmh.1 uc288zmh.2 
ENSMUST00000181155.6 Carmn ENSMUST00000181155.6 Carmn (from geneSymbol) AK087736 ENSMUST00000181155.1 ENSMUST00000181155.2 ENSMUST00000181155.3 ENSMUST00000181155.4 ENSMUST00000181155.5 uc289phi.1 uc289phi.2 uc289phi.3 uc289phi.4 uc289phi.1 uc289phi.2 uc289phi.3 uc289phi.4 
ENSMUST00000181163.2 Gm20865 ENSMUST00000181163.2 Belongs to the SPIN/STSY family. (from UniProt Q62460) ENSMUST00000181163.1 Gm20865 Q62460 Q62460_MOUSE uc029xsn.1 uc029xsn.2 uc029xsn.3 uc029xsn.4 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc029xsn.1 uc029xsn.2 uc029xsn.3 uc029xsn.4 
ENSMUST00000181168.2 B430218F22Rik ENSMUST00000181168.2 B430218F22Rik (from geneSymbol) AK046645 ENSMUST00000181168.1 uc288qed.1 uc288qed.2 uc288qed.1 uc288qed.2 
ENSMUST00000181170.2 B930036N10Rik ENSMUST00000181170.2 B930036N10Rik (from geneSymbol) AK047216 ENSMUST00000181170.1 uc287nuw.1 uc287nuw.2 uc287nuw.1 uc287nuw.2 
ENSMUST00000181173.2 Gapdhrt ENSMUST00000181173.2 Reaction=D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3- phospho-glyceroyl phosphate + H(+) + NADH; Xref=Rhea:RHEA:10300, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57540, ChEBI:CHEBI:57604, ChEBI:CHEBI:57945, ChEBI:CHEBI:59776; EC=1.2.1.12; Evidence= (from UniProt S4R1W1) BC092063 ENSMUST00000181173.1 Gapdhrt Gm3839 S4R1W1 S4R1W1_MOUSE uc288qsy.1 uc288qsy.2 Reaction=D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3- phospho-glyceroyl phosphate + H(+) + NADH; Xref=Rhea:RHEA:10300, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57540, ChEBI:CHEBI:57604, ChEBI:CHEBI:57945, ChEBI:CHEBI:59776; EC=1.2.1.12; Evidence= Reaction=L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] = L- cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]; Xref=Rhea:RHEA:66684, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:17089, Rhea:RHEA-COMP:17090, Rhea:RHEA-COMP:17091, ChEBI:CHEBI:29950, ChEBI:CHEBI:149494; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66685; Evidence=; Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 1/5. Homotetramer. Cytoplasm, cytoskeleton Cytoplasm, cytosol Nucleus Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. nucleotide binding glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity cytosol glucose metabolic process glycolytic process oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor NADP binding NAD binding oxidation-reduction process uc288qsy.1 uc288qsy.2 
ENSMUST00000181174.2 D630044L22Rik ENSMUST00000181174.2 RIKEN cDNA gene D630044L22 gene (from RefSeq NR_152187.1) ENSMUST00000181174.1 NR_152187 uc289inq.1 uc289inq.2 uc289inq.1 uc289inq.2 
ENSMUST00000181176.3 Gm26688 ENSMUST00000181176.3 predicted gene, 26688 (from RefSeq NR_125899.1) ENSMUST00000181176.1 ENSMUST00000181176.2 NR_125899 uc007qek.1 uc007qek.2 uc007qek.1 uc007qek.2 
ENSMUST00000181178.2 Gm26814 ENSMUST00000181178.2 Gm26814 (from geneSymbol) ENSMUST00000181178.1 uc291cje.1 uc291cje.2 uc291cje.1 uc291cje.2 
ENSMUST00000181179.5 Alyreffm13 ENSMUST00000181179.5 predicted gene 8764 (from RefSeq NM_001270900.1) ENSMUST00000181179.1 ENSMUST00000181179.2 ENSMUST00000181179.3 ENSMUST00000181179.4 Gm20765 Gm21293 Gm21304 Gm21312 Gm6763 Gm8764 M0QWB2 M0QWR4 M0QWR4_MOUSE NM_001270900 uc057kjr.1 uc057kjr.2 uc057kjr.3 nucleic acid binding RNA binding uc057kjr.1 uc057kjr.2 uc057kjr.3 
ENSMUST00000181190.3 4933404O12Rik ENSMUST00000181190.3 4933404O12Rik (from geneSymbol) AK169739 ENSMUST00000181190.1 ENSMUST00000181190.2 uc009abe.1 uc009abe.2 uc009abe.3 uc009abe.4 uc009abe.1 uc009abe.2 uc009abe.3 uc009abe.4 
ENSMUST00000181197.2 Gm26783 ENSMUST00000181197.2 Gm26783 (from geneSymbol) AK081172 ENSMUST00000181197.1 uc287lxj.1 uc287lxj.2 uc287lxj.1 uc287lxj.2 
ENSMUST00000181200.2 Gm26815 ENSMUST00000181200.2 Gm26815 (from geneSymbol) AK050787 ENSMUST00000181200.1 uc292dpq.1 uc292dpq.2 uc292dpq.1 uc292dpq.2 
ENSMUST00000181205.2 Gm20909 ENSMUST00000181205.2 predicted gene, 20909 (from RefSeq NM_001384234.1) ENSMUST00000181205.1 Gm20747 Gm20801 Gm20909 Gm21683 LOC434960 NM_001384234 Q5FWB5 Q5FWB5_MOUSE uc292smu.1 uc292smu.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292smu.1 uc292smu.2 
ENSMUST00000181209.2 6030443J06Rik ENSMUST00000181209.2 6030443J06Rik (from geneSymbol) AK030448 ENSMUST00000181209.1 uc008wpt.1 uc008wpt.2 uc008wpt.3 uc008wpt.4 uc008wpt.1 uc008wpt.2 uc008wpt.3 uc008wpt.4 
ENSMUST00000181210.3 Trav6-5 ENSMUST00000181210.3 Trav6-5 (from geneSymbol) A0A075B6B5 A0A075B6B5_MOUSE ENSMUST00000181210.1 ENSMUST00000181210.2 Trav6-5 X02969 uc011zkw.1 uc011zkw.2 uc011zkw.3 uc011zkw.4 immunoglobulin production extracellular space immune response uc011zkw.1 uc011zkw.2 uc011zkw.3 uc011zkw.4 
ENSMUST00000181211.2 Gm17552 ENSMUST00000181211.2 Gm17552 (from geneSymbol) AK087383 ENSMUST00000181211.1 uc289qbt.1 uc289qbt.2 uc289qbt.1 uc289qbt.2 
ENSMUST00000181215.3 Gm17508 ENSMUST00000181215.3 Gm17508 (from geneSymbol) AK144297 ENSMUST00000181215.1 ENSMUST00000181215.2 uc009orh.1 uc009orh.2 uc009orh.3 uc009orh.1 uc009orh.2 uc009orh.3 
ENSMUST00000181223.8 ENSMUSG00000121430 ENSMUST00000181223.8 RIKEN cDNA C920009B18 gene (from RefSeq NR_015465.3) ENSMUST00000181223.1 ENSMUST00000181223.2 ENSMUST00000181223.3 ENSMUST00000181223.4 ENSMUST00000181223.5 ENSMUST00000181223.6 ENSMUST00000181223.7 NR_015465 uc007epk.1 uc007epk.2 uc007epk.3 uc007epk.4 uc007epk.1 uc007epk.2 uc007epk.3 uc007epk.4 
ENSMUST00000181227.2 Gm26716 ENSMUST00000181227.2 Gm26716 (from geneSymbol) ENSMUST00000181227.1 uc290qhn.1 uc290qhn.2 uc290qhn.1 uc290qhn.2 
ENSMUST00000181230.2 4833428L15Rik ENSMUST00000181230.2 RIKEN cDNA 4833428L15 gene (from RefSeq NR_040732.1) ENSMUST00000181230.1 NR_040732 uc009pfw.1 uc009pfw.2 uc009pfw.1 uc009pfw.2 
ENSMUST00000181255.2 Gm17638 ENSMUST00000181255.2 Gm17638 (from geneSymbol) AK137428 ENSMUST00000181255.1 uc007won.1 uc007won.2 uc007won.1 uc007won.2 
ENSMUST00000181258.2 Gm26811 ENSMUST00000181258.2 Gm26811 (from geneSymbol) AK133156 ENSMUST00000181258.1 uc291gxf.1 uc291gxf.2 uc291gxf.1 uc291gxf.2 
ENSMUST00000181275.3 Gm16982 ENSMUST00000181275.3 predicted gene, 16982 (from RefSeq NR_040337.1) ENSMUST00000181275.1 ENSMUST00000181275.2 NR_040337 uc009klt.1 uc009klt.2 uc009klt.3 uc009klt.1 uc009klt.2 uc009klt.3 
ENSMUST00000181277.3 Gm17249 ENSMUST00000181277.3 Gm17249 (from geneSymbol) AK134099 ENSMUST00000181277.1 ENSMUST00000181277.2 uc287trg.1 uc287trg.2 uc287trg.1 uc287trg.2 
ENSMUST00000181287.5 Alyreffm14 ENSMUST00000181287.5 predicted gene 6763 (from RefSeq NM_001270899.1) ENSMUST00000181287.1 ENSMUST00000181287.2 ENSMUST00000181287.3 ENSMUST00000181287.4 Gm20765 Gm21293 Gm21304 Gm21312 Gm6763 Gm8764 M0QWB2 M0QWR4 M0QWR4_MOUSE NM_001270899 uc057kjp.1 uc057kjp.2 uc057kjp.3 nucleic acid binding RNA binding uc057kjp.1 uc057kjp.2 uc057kjp.3 
ENSMUST00000181289.2 Gm17322 ENSMUST00000181289.2 Gm17322 (from geneSymbol) AK163559 ENSMUST00000181289.1 uc009pvz.1 uc009pvz.2 uc009pvz.1 uc009pvz.2 
ENSMUST00000181291.8 9530082P21Rik ENSMUST00000181291.8 9530082P21Rik (from geneSymbol) AK037113 ENSMUST00000181291.1 ENSMUST00000181291.2 ENSMUST00000181291.3 ENSMUST00000181291.4 ENSMUST00000181291.5 ENSMUST00000181291.6 ENSMUST00000181291.7 uc008ate.1 uc008ate.2 uc008ate.3 uc008ate.1 uc008ate.2 uc008ate.3 
ENSMUST00000181299.3 A730056A06Rik ENSMUST00000181299.3 RIKEN cDNA A730056A06 gene, transcript variant 2 (from RefSeq NR_040325.1) ENSMUST00000181299.1 ENSMUST00000181299.2 NR_040325 uc009hqy.1 uc009hqy.2 uc009hqy.3 uc009hqy.4 uc009hqy.1 uc009hqy.2 uc009hqy.3 uc009hqy.4 
ENSMUST00000181306.3 D930007P13Rik ENSMUST00000181306.3 Riken cDNA D930007P13 gene (from RefSeq NR_045743.1) ENSMUST00000181306.1 ENSMUST00000181306.2 NR_045743 uc029svj.1 uc029svj.2 uc029svj.3 uc029svj.1 uc029svj.2 uc029svj.3 
ENSMUST00000181308.3 Ptgs2os2 ENSMUST00000181308.3 prostaglandin-endoperoxide synthase 2, opposite strand 2 (from RefSeq NR_110420.1) ENSMUST00000181308.1 ENSMUST00000181308.2 NR_110420 uc033fmh.1 uc033fmh.2 uc033fmh.3 uc033fmh.1 uc033fmh.2 uc033fmh.3 
ENSMUST00000181311.2 Gm10101 ENSMUST00000181311.2 Gm10101 (from geneSymbol) ENSMUST00000181311.1 uc288tck.1 uc288tck.2 uc288tck.1 uc288tck.2 
ENSMUST00000181312.2 Gm26738 ENSMUST00000181312.2 Gm26738 (from geneSymbol) ENSMUST00000181312.1 uc291csw.1 uc291csw.2 uc291csw.1 uc291csw.2 
ENSMUST00000181317.4 Gm26826 ENSMUST00000181317.4 Gm26826 (from geneSymbol) AK135206 ENSMUST00000181317.1 ENSMUST00000181317.2 ENSMUST00000181317.3 uc291iqb.1 uc291iqb.2 uc291iqb.3 uc291iqb.1 uc291iqb.2 uc291iqb.3 
ENSMUST00000181318.2 Gm26693 ENSMUST00000181318.2 Gm26693 (from geneSymbol) AK086403 ENSMUST00000181318.1 uc289jsa.1 uc289jsa.2 uc289jsa.1 uc289jsa.2 
ENSMUST00000181325.5 E530011L22Rik ENSMUST00000181325.5 E530011L22Rik (from geneSymbol) ENSMUST00000181325.1 ENSMUST00000181325.2 ENSMUST00000181325.3 ENSMUST00000181325.4 LF197874 uc012hcq.1 uc012hcq.2 uc012hcq.3 uc012hcq.4 uc012hcq.1 uc012hcq.2 uc012hcq.3 uc012hcq.4 
ENSMUST00000181327.2 4930554H23Rik ENSMUST00000181327.2 RIKEN cDNA 4930554H23 gene (from RefSeq NR_131089.1) ENSMUST00000181327.1 NR_131089 uc057ahp.1 uc057ahp.2 uc057ahp.3 uc057ahp.1 uc057ahp.2 uc057ahp.3 
ENSMUST00000181333.2 Gm27021 ENSMUST00000181333.2 predicted gene, 27021 (from RefSeq NM_001308449.1) ENSMUST00000181333.1 Gm27021 M0QWE2 M0QWE2_MOUSE NM_001308449 uc057ccr.1 uc057ccr.2 uc057ccr.3 This locus represents naturally occurring readthrough transcription between the neighboring ER membrane protein complex subunit 8 and RIKEN cDNA 1190005I06 genes on chromosome 8. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, May 2015]. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849374 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 18117, 68918 ##RefSeq-Attributes-END## ER membrane protein complex uc057ccr.1 uc057ccr.2 uc057ccr.3 
ENSMUST00000181338.3 Gm26714 ENSMUST00000181338.3 Gm26714 (from geneSymbol) AK044104 ENSMUST00000181338.1 ENSMUST00000181338.2 uc291ytw.1 uc291ytw.2 uc291ytw.3 uc291ytw.1 uc291ytw.2 uc291ytw.3 
ENSMUST00000181342.2 Gm26789 ENSMUST00000181342.2 Gm26789 (from geneSymbol) ENSMUST00000181342.1 uc287rtg.1 uc287rtg.2 uc287rtg.1 uc287rtg.2 
ENSMUST00000181348.3 4921507G05Rik ENSMUST00000181348.3 4921507G05Rik (from geneSymbol) AK014831 ENSMUST00000181348.1 ENSMUST00000181348.2 uc007pbz.1 uc007pbz.2 uc007pbz.3 uc007pbz.1 uc007pbz.2 uc007pbz.3 
ENSMUST00000181355.4 Gm26588 ENSMUST00000181355.4 Gm26588 (from geneSymbol) AK029023 ENSMUST00000181355.1 ENSMUST00000181355.2 ENSMUST00000181355.3 uc009cvm.1 uc009cvm.2 uc009cvm.3 uc009cvm.1 uc009cvm.2 uc009cvm.3 
ENSMUST00000181358.8 1700034P13Rik ENSMUST00000181358.8 1700034P13Rik (from geneSymbol) AK006607 ENSMUST00000181358.1 ENSMUST00000181358.2 ENSMUST00000181358.3 ENSMUST00000181358.4 ENSMUST00000181358.5 ENSMUST00000181358.6 ENSMUST00000181358.7 uc287gjr.1 uc287gjr.2 uc287gjr.1 uc287gjr.2 
ENSMUST00000181360.3 Trav12d-1 ENSMUST00000181360.3 Trav12d-1 (from geneSymbol) A0N8R0 A0N8R0_MOUSE AK041819 ENSMUST00000181360.1 ENSMUST00000181360.2 Trav12d-1 Trav12n-1 uc288twx.1 uc288twx.2 immunoglobulin production molecular_function extracellular space immune response uc288twx.1 uc288twx.2 
ENSMUST00000181362.3 Gm26704 ENSMUST00000181362.3 Gm26704 (from geneSymbol) ENSMUST00000181362.1 ENSMUST00000181362.2 LF203235 uc288xtx.1 uc288xtx.2 uc288xtx.1 uc288xtx.2 
ENSMUST00000181370.2 Gm26703 ENSMUST00000181370.2 Gm26703 (from geneSymbol) AK043904 ENSMUST00000181370.1 uc008ykc.1 uc008ykc.2 uc008ykc.1 uc008ykc.2 
ENSMUST00000181378.3 Gm26665 ENSMUST00000181378.3 Gm26665 (from geneSymbol) AK053286 ENSMUST00000181378.1 ENSMUST00000181378.2 uc057khf.1 uc057khf.2 uc057khf.3 uc057khf.1 uc057khf.2 uc057khf.3 
ENSMUST00000181381.3 4930519A11Rik ENSMUST00000181381.3 4930519A11Rik (from geneSymbol) AK015836 ENSMUST00000181381.1 ENSMUST00000181381.2 uc288eyn.1 uc288eyn.2 uc288eyn.1 uc288eyn.2 
ENSMUST00000181383.5 Gm17634 ENSMUST00000181383.5 predicted gene, 17634, transcript variant 3 (from RefSeq NR_151540.1) ENSMUST00000181383.1 ENSMUST00000181383.2 ENSMUST00000181383.3 ENSMUST00000181383.4 NR_151540 uc007cge.1 uc007cge.2 uc007cge.3 uc007cge.4 uc007cge.1 uc007cge.2 uc007cge.3 uc007cge.4 
ENSMUST00000181385.2 Gm26781 ENSMUST00000181385.2 Gm26781 (from geneSymbol) AK041859 ENSMUST00000181385.1 uc287mcj.1 uc287mcj.2 uc287mcj.1 uc287mcj.2 
ENSMUST00000181390.3 Gm26873 ENSMUST00000181390.3 Gm26873 (from geneSymbol) AK079171 ENSMUST00000181390.1 ENSMUST00000181390.2 uc289hio.1 uc289hio.2 uc289hio.1 uc289hio.2 
ENSMUST00000181391.8 Zfp273 ENSMUST00000181391.8 zinc finger protein 273 (from RefSeq NM_198322.3) ENSMUST00000181391.1 ENSMUST00000181391.2 ENSMUST00000181391.3 ENSMUST00000181391.4 ENSMUST00000181391.5 ENSMUST00000181391.6 ENSMUST00000181391.7 NM_198322 Q7M6W8 Q7M6W8_MOUSE Rslcan1 Zfp273 uc007rbr.1 uc007rbr.2 uc007rbr.3 uc007rbr.4 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007rbr.1 uc007rbr.2 uc007rbr.3 uc007rbr.4 
ENSMUST00000181393.8 D930032P07Rik ENSMUST00000181393.8 RIKEN cDNA D930032P07 gene (from RefSeq NR_045330.1) ENSMUST00000181393.1 ENSMUST00000181393.2 ENSMUST00000181393.3 ENSMUST00000181393.4 ENSMUST00000181393.5 ENSMUST00000181393.6 ENSMUST00000181393.7 NR_045330 uc029trx.1 uc029trx.2 uc029trx.1 uc029trx.2 
ENSMUST00000181395.2 Gm4673 ENSMUST00000181395.2 Gm4673 (from geneSymbol) AK154275 ENSMUST00000181395.1 uc009ghi.1 uc009ghi.2 uc009ghi.1 uc009ghi.2 
ENSMUST00000181398.3 Gm43972 ENSMUST00000181398.3 Gm43972 (from geneSymbol) ENSMUST00000181398.1 ENSMUST00000181398.2 uc290tul.1 uc290tul.2 uc290tul.1 uc290tul.2 
ENSMUST00000181399.3 Gm26571 ENSMUST00000181399.3 Gm26571 (from geneSymbol) ENSMUST00000181399.1 ENSMUST00000181399.2 uc288htc.1 uc288htc.2 uc288htc.3 uc288htc.1 uc288htc.2 uc288htc.3 
ENSMUST00000181401.8 Rpgrip1 ENSMUST00000181401.8 Belongs to the RPGRIP1 family. (from UniProt E7CHD7) E7CHD7 E7CHD7_MOUSE ENSMUST00000181401.1 ENSMUST00000181401.2 ENSMUST00000181401.3 ENSMUST00000181401.4 ENSMUST00000181401.5 ENSMUST00000181401.6 ENSMUST00000181401.7 HM067441 Rpgrip1 uc011zkk.1 uc011zkk.2 uc011zkk.3 Belongs to the RPGRIP1 family. visual perception photoreceptor connecting cilium eye photoreceptor cell development uc011zkk.1 uc011zkk.2 uc011zkk.3 
ENSMUST00000181404.2 Gm26544 ENSMUST00000181404.2 Gm26544 (from geneSymbol) AK033312 ENSMUST00000181404.1 uc290iyu.1 uc290iyu.2 uc290iyu.1 uc290iyu.2 
ENSMUST00000181406.2 AW047730 ENSMUST00000181406.2 AW047730 (from geneSymbol) BC072659 ENSMUST00000181406.1 uc290glq.1 uc290glq.2 uc290glq.1 uc290glq.2 
ENSMUST00000181411.2 Gm26766 ENSMUST00000181411.2 predicted gene, 26766 (from RefSeq NR_171015.1) ENSMUST00000181411.1 NR_171015 uc007vnc.1 uc007vnc.2 uc007vnc.3 uc007vnc.1 uc007vnc.2 uc007vnc.3 
ENSMUST00000181414.3 Gm10614 ENSMUST00000181414.3 Gm10614 (from geneSymbol) AK141770 ENSMUST00000181414.1 ENSMUST00000181414.2 uc292dnu.1 uc292dnu.2 uc292dnu.3 uc292dnu.1 uc292dnu.2 uc292dnu.3 
ENSMUST00000181416.9 Pvt1 ENSMUST00000181416.9 Pvt1 (from geneSymbol) AK090048 ENSMUST00000181416.1 ENSMUST00000181416.2 ENSMUST00000181416.3 ENSMUST00000181416.4 ENSMUST00000181416.5 ENSMUST00000181416.6 ENSMUST00000181416.7 ENSMUST00000181416.8 uc007vym.1 uc007vym.2 uc007vym.3 uc007vym.4 uc007vym.1 uc007vym.2 uc007vym.3 uc007vym.4 
ENSMUST00000181432.3 4933417D19Rik ENSMUST00000181432.3 RIKEN cDNA 4933417D19 gene (from RefSeq NR_045849.1) ENSMUST00000181432.1 ENSMUST00000181432.2 NR_045849 uc009nur.1 uc009nur.2 uc009nur.3 uc009nur.1 uc009nur.2 uc009nur.3 
ENSMUST00000181436.3 Gm26583 ENSMUST00000181436.3 Gm26583 (from geneSymbol) AK081545 ENSMUST00000181436.1 ENSMUST00000181436.2 uc288jpi.1 uc288jpi.2 uc288jpi.3 uc288jpi.1 uc288jpi.2 uc288jpi.3 
ENSMUST00000181438.2 4930534D22Rik ENSMUST00000181438.2 4930534D22Rik (from geneSymbol) AK090212 ENSMUST00000181438.1 uc290jte.1 uc290jte.2 uc290jte.1 uc290jte.2 
ENSMUST00000181439.2 Gm7337 ENSMUST00000181439.2 predicted gene 7337 (from RefSeq NR_003652.2) ENSMUST00000181439.1 NR_003652 uc008xzc.1 uc008xzc.2 uc008xzc.3 uc008xzc.1 uc008xzc.2 uc008xzc.3 
ENSMUST00000181440.3 BC051077 ENSMUST00000181440.3 cDNA sequence BC051077 (from RefSeq NR_188759.1) ENSMUST00000181440.1 ENSMUST00000181440.2 NR_188759 uc008zfm.1 uc008zfm.2 uc008zfm.1 uc008zfm.2 
ENSMUST00000181444.2 Peak1os ENSMUST00000181444.2 Peak1os (from geneSymbol) AK153735 ENSMUST00000181444.1 uc292hln.1 uc292hln.2 uc292hln.1 uc292hln.2 
ENSMUST00000181454.7 2310002F09Rik ENSMUST00000181454.7 2310002F09Rik (from geneSymbol) AK134755 ENSMUST00000181454.1 ENSMUST00000181454.2 ENSMUST00000181454.3 ENSMUST00000181454.4 ENSMUST00000181454.5 ENSMUST00000181454.6 uc009gnj.1 uc009gnj.2 uc009gnj.1 uc009gnj.2 
ENSMUST00000181458.2 Gm26831 ENSMUST00000181458.2 Gm26831 (from geneSymbol) ENSMUST00000181458.1 uc287ldl.1 uc287ldl.2 uc287ldl.1 uc287ldl.2 
ENSMUST00000181462.2 Gm26631 ENSMUST00000181462.2 Gm26631 (from geneSymbol) AK048762 ENSMUST00000181462.1 uc292hoy.1 uc292hoy.2 uc292hoy.1 uc292hoy.2 
ENSMUST00000181474.2 Gm26537 ENSMUST00000181474.2 Gm26537 (from geneSymbol) ENSMUST00000181474.1 uc292dnz.1 uc292dnz.2 uc292dnz.1 uc292dnz.2 
ENSMUST00000181476.3 Gm16863 ENSMUST00000181476.3 predicted gene, 16863 (from RefSeq NR_046162.1) ENSMUST00000181476.1 ENSMUST00000181476.2 NR_046162 uc007yri.1 uc007yri.2 uc007yri.1 uc007yri.2 
ENSMUST00000181479.2 B230364G03Rik ENSMUST00000181479.2 B230364G03Rik (from geneSymbol) AK046279 ENSMUST00000181479.1 uc287prv.1 uc287prv.2 uc287prv.1 uc287prv.2 
ENSMUST00000181483.3 Trav6d-3 ENSMUST00000181483.3 Trav6d-3 (from geneSymbol) A0A075B6B3 A0A075B6B3_MOUSE ENSMUST00000181483.1 ENSMUST00000181483.2 M61133 Trav6d-3 uc288twm.1 uc288twm.2 immunoglobulin production extracellular space immune response uc288twm.1 uc288twm.2 
ENSMUST00000181495.2 4732487G21Rik ENSMUST00000181495.2 4732487G21Rik (from geneSymbol) AK042422 ENSMUST00000181495.1 uc288ias.1 uc288ias.2 uc288ias.1 uc288ias.2 
ENSMUST00000181498.3 Gm16861 ENSMUST00000181498.3 predicted gene, 16861 (from RefSeq NR_037666.1) ENSMUST00000181498.1 ENSMUST00000181498.2 NR_037666 uc007yat.1 uc007yat.2 uc007yat.3 uc007yat.4 uc007yat.1 uc007yat.2 uc007yat.3 uc007yat.4 
ENSMUST00000181501.3 9330104G04Rik ENSMUST00000181501.3 RIKEN cDNA 9330104G04 gene (from RefSeq NR_152128.1) ENSMUST00000181501.1 ENSMUST00000181501.2 NR_152128 uc291mcv.1 uc291mcv.2 uc291mcv.1 uc291mcv.2 
ENSMUST00000181504.2 Foxf1 ENSMUST00000181504.2 forkhead box F1 (from RefSeq NM_010426.3) B2RSC1 ENSMUST00000181504.1 FOXF1_MOUSE Fkhl5 Foxf1a Freac1 Hfh8 NM_010426 Q61080 Q61661 uc009nrn.1 uc009nrn.2 uc009nrn.3 uc009nrn.4 Probable transcription activator for a number of lung- specific genes. Nucleus Expressed primarily in lung in alveolar type II pneumocyte cells, and to a lesser extent in placenta, stomach, intestine and colon. Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation. It is uncertain whether Met-1 or Met-26 is the initiator. Sequence=AAI38806.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI38807.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAK35051.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding blood vessel development vasculogenesis in utero embryonic development somitogenesis morphogenesis of a branching structure positive regulation of mesenchymal cell proliferation endocardial cushion development cardiac left ventricle morphogenesis DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated smoothened signaling pathway determination of left/right symmetry midgut development mesoderm development heart development animal organ morphogenesis positive regulation of cell-substrate adhesion detection of wounding extracellular matrix organization respiratory tube development lung development positive regulation of cell migration pancreas development negative regulation of mast cell degranulation sequence-specific DNA binding transcription regulatory region DNA binding establishment of epithelial cell apical/basal polarity positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lung alveolus development lateral mesodermal cell differentiation embryonic digestive tract morphogenesis digestive tract development embryonic digestive tract development embryonic ectodermal digestive tract morphogenesis embryonic foregut morphogenesis negative regulation of inflammatory response smooth muscle cell differentiation lung morphogenesis lung vasculature development trachea development epithelial tube branching involved in lung morphogenesis right lung morphogenesis lung lobe morphogenesis venous blood vessel development epithelial cell differentiation involved in mammary gland alveolus development cellular response to cytokine stimulus cellular response to organic cyclic compound renal system development ureter development mesenchyme migration ductus arteriosus closure cell-cell adhesion uc009nrn.1 uc009nrn.2 uc009nrn.3 uc009nrn.4 
ENSMUST00000181509.2 4930521O11Rik ENSMUST00000181509.2 4930521O11Rik (from geneSymbol) AK007159 ENSMUST00000181509.1 uc007sec.1 uc007sec.2 uc007sec.3 uc007sec.1 uc007sec.2 uc007sec.3 
ENSMUST00000181510.3 B130046B21Rik ENSMUST00000181510.3 B130046B21Rik (from geneSymbol) AK157795 ENSMUST00000181510.1 ENSMUST00000181510.2 uc007xnz.1 uc007xnz.2 uc007xnz.1 uc007xnz.2 
ENSMUST00000181511.11 Mir9-3hg ENSMUST00000181511.11 Mir9-3 host gene, transcript variant 4 (from RefSeq NR_040314.1) ENSMUST00000181511.1 ENSMUST00000181511.10 ENSMUST00000181511.2 ENSMUST00000181511.3 ENSMUST00000181511.4 ENSMUST00000181511.5 ENSMUST00000181511.6 ENSMUST00000181511.7 ENSMUST00000181511.8 ENSMUST00000181511.9 NR_040314 uc009hyl.1 uc009hyl.2 uc009hyl.3 uc009hyl.4 uc009hyl.5 uc009hyl.6 uc009hyl.1 uc009hyl.2 uc009hyl.3 uc009hyl.4 uc009hyl.5 uc009hyl.6 
ENSMUST00000181515.2 Carlr ENSMUST00000181515.2 cardiac and apoptosis-related long non-coding RNA (from RefSeq NR_131254.1) A0A668KLV5 A0A668KLV5_MOUSE Carlr ENSMUST00000181515.1 NR_131254 uc057bmo.1 uc057bmo.2 uc057bmo.3 uc057bmo.1 uc057bmo.2 uc057bmo.3 
ENSMUST00000181520.3 Gm17259 ENSMUST00000181520.3 Gm17259 (from geneSymbol) AK161157 ENSMUST00000181520.1 ENSMUST00000181520.2 uc288ovy.1 uc288ovy.2 uc288ovy.3 uc288ovy.1 uc288ovy.2 uc288ovy.3 
ENSMUST00000181531.3 Gm26553 ENSMUST00000181531.3 Gm26553 (from geneSymbol) AK015488 ENSMUST00000181531.1 ENSMUST00000181531.2 uc008qmt.1 uc008qmt.2 uc008qmt.3 uc008qmt.1 uc008qmt.2 uc008qmt.3 
ENSMUST00000181534.2 Gm26774 ENSMUST00000181534.2 Gm26774 (from geneSymbol) AK133452 ENSMUST00000181534.1 uc291clc.1 uc291clc.2 uc291clc.1 uc291clc.2 
ENSMUST00000181536.5 Snhg18 ENSMUST00000181536.5 Snhg18 (from geneSymbol) AK002304 ENSMUST00000181536.1 ENSMUST00000181536.2 ENSMUST00000181536.3 ENSMUST00000181536.4 uc007vkn.1 uc007vkn.2 uc007vkn.3 uc007vkn.4 uc007vkn.5 uc007vkn.6 uc007vkn.1 uc007vkn.2 uc007vkn.3 uc007vkn.4 uc007vkn.5 uc007vkn.6 
ENSMUST00000181541.2 Tdpoz1 ENSMUST00000181541.2 TD and POZ domain containing 1 (from RefSeq NM_148949.2) 2cpoz56 ENSMUST00000181541.1 Mapp2 NM_148949 P0DMR5 Q717B3 Q71G58 Q8BZV7 Q8VI39 Spopl1 TDPZ1_MOUSE Tdpoz1 uc008qfm.1 uc008qfm.2 uc008qfm.3 uc008qfm.4 Expressed in unfertilized eggs and pre- implantation embryos. Undetectable in later-stage fetuses or in adult tissues. Belongs to the Tdpoz family. Sequence=AAL40187.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleus cytoplasm ubiquitin-dependent protein catabolic process regulation of proteolysis ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process uc008qfm.1 uc008qfm.2 uc008qfm.3 uc008qfm.4 
ENSMUST00000181546.2 5031415H12Rik ENSMUST00000181546.2 5031415H12Rik (from geneSymbol) AK145139 ENSMUST00000181546.1 uc289moe.1 uc289moe.2 uc289moe.1 uc289moe.2 
ENSMUST00000181547.3 4933440J02Rik ENSMUST00000181547.3 RIKEN cDNA 4933440J02 gene (from RefSeq NR_045344.1) ENSMUST00000181547.1 ENSMUST00000181547.2 NR_045344 uc029rfn.1 uc029rfn.2 uc029rfn.3 uc029rfn.1 uc029rfn.2 uc029rfn.3 
ENSMUST00000181549.2 Gm20854 ENSMUST00000181549.2 Belongs to the SPIN/STSY family. (from UniProt Q62461) ENSMUST00000181549.1 Gm20854 Q62461 Q62461_MOUSE Ssty2 uc292uwe.1 uc292uwe.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292uwe.1 uc292uwe.2 
ENSMUST00000181553.2 4930544M13Rik ENSMUST00000181553.2 RIKEN cDNA 4930544M13 gene (from RefSeq NR_045976.1) ENSMUST00000181553.1 NR_045976 uc007rxr.1 uc007rxr.2 uc007rxr.3 uc007rxr.1 uc007rxr.2 uc007rxr.3 
ENSMUST00000181558.3 Gm6225 ENSMUST00000181558.3 predicted gene 6225 (from RefSeq NR_033457.1) ENSMUST00000181558.1 ENSMUST00000181558.2 NR_033457 uc008dxy.1 uc008dxy.2 uc008dxy.3 uc008dxy.4 uc008dxy.1 uc008dxy.2 uc008dxy.3 uc008dxy.4 
ENSMUST00000181562.9 Gm3488 ENSMUST00000181562.9 predicted gene, 3488, transcript variant 2 (from RefSeq NM_001256885.1) ENSMUST00000181562.1 ENSMUST00000181562.2 ENSMUST00000181562.3 ENSMUST00000181562.4 ENSMUST00000181562.5 ENSMUST00000181562.6 ENSMUST00000181562.7 ENSMUST00000181562.8 Gm3488 M0QW81 M0QW81_MOUSE NM_001256885 uc288qmg.1 uc288qmg.2 uc288qmg.3 uc288qmg.1 uc288qmg.2 uc288qmg.3 
ENSMUST00000181563.3 Gm10561 ENSMUST00000181563.3 Gm10561 (from geneSymbol) AK135004 ENSMUST00000181563.1 ENSMUST00000181563.2 uc007bai.1 uc007bai.2 uc007bai.3 uc007bai.1 uc007bai.2 uc007bai.3 
ENSMUST00000181566.2 Gsg1l2 ENSMUST00000181566.2 GSG1-like 2 (from RefSeq NM_001347057.1) ENSMUST00000181566.1 Gm12302 Gsg1l2 M0QWL6 M0QWL6_MOUSE NM_001347057 uc057kli.1 uc057kli.2 uc057kli.3 Membrane ; Multi- pass membrane protein Belongs to the GSG1 family. molecular_function plasma membrane biological_process membrane integral component of membrane uc057kli.1 uc057kli.2 uc057kli.3 
ENSMUST00000181586.8 Cox4i1 ENSMUST00000181586.8 cytochrome c oxidase subunit 4I1, transcript variant 2 (from RefSeq NM_001293559.1) COX41_MOUSE Cox4 Cox4a ENSMUST00000181586.1 ENSMUST00000181586.2 ENSMUST00000181586.3 ENSMUST00000181586.4 ENSMUST00000181586.5 ENSMUST00000181586.6 ENSMUST00000181586.7 NM_001293559 P19783 Q545A9 uc009nri.1 uc009nri.2 uc009nri.3 uc009nri.4 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Energy metabolism; oxidative phosphorylation. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with PHB2; the interaction decreases in absence of SPHK2 (PubMed:20959514). Interacts with AFG1L (By similarity). Interacts with ABCB7; this interaction allows the regulation of cellular iron homeostasis and cellular reactive oxygen species (ROS) levels in cardiomyocytes (By similarity). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding. Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the cytochrome c oxidase IV family. cytochrome-c oxidase activity protein binding nucleus mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex IV mitochondrial electron transport, cytochrome c to oxygen response to nutrient membrane mitochondrial membrane hydrogen ion transmembrane transport uc009nri.1 uc009nri.2 uc009nri.3 uc009nri.4 
ENSMUST00000181592.2 I830134H01Rik ENSMUST00000181592.2 I830134H01Rik (from geneSymbol) ENSMUST00000181592.1 LF201761 uc008hiw.1 uc008hiw.2 uc008hiw.3 uc008hiw.1 uc008hiw.2 uc008hiw.3 
ENSMUST00000181598.3 1500026H17Rik ENSMUST00000181598.3 RIKEN cDNA 1500026H17 gene (from RefSeq NR_130956.1) ENSMUST00000181598.1 ENSMUST00000181598.2 NR_130956 uc007gsr.1 uc007gsr.2 uc007gsr.3 uc007gsr.4 uc007gsr.5 uc007gsr.1 uc007gsr.2 uc007gsr.3 uc007gsr.4 uc007gsr.5 
ENSMUST00000181602.3 Gm26535 ENSMUST00000181602.3 Gm26535 (from geneSymbol) AK042044 ENSMUST00000181602.1 ENSMUST00000181602.2 uc057kii.1 uc057kii.2 uc057kii.3 uc057kii.1 uc057kii.2 uc057kii.3 
ENSMUST00000181609.2 Foxl1 ENSMUST00000181609.2 forkhead box L1 (from RefSeq NM_008024.3) B2RQ86 ENSMUST00000181609.1 FOXL1_MOUSE Fkh6 Fkhl11 NM_008024 Q64731 uc009nrs.1 uc009nrs.2 uc009nrs.3 Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 and GLI3 transcription factors. Nucleus. Deficient mice show postnatal growth retardation secondary to severe structural abnormalities of the stomach, duodenum, jejunum and decreased intestinal uptake of D-glucose and levels of the intestinal D-glucose transporter Slc5a1. Sequence=CAA63243.1; Type=Frameshift; Evidence=; RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter visceral mesoderm-endoderm interaction involved in midgut development heart development anatomical structure morphogenesis regulation of Wnt signaling pathway cell differentiation proteoglycan biosynthetic process sequence-specific DNA binding Peyer's patch morphogenesis uc009nrs.1 uc009nrs.2 uc009nrs.3 
ENSMUST00000181615.8 Alyreffm10 ENSMUST00000181615.8 predicted gene 4340 (from RefSeq NM_001177535.1) ENSMUST00000181615.1 ENSMUST00000181615.2 ENSMUST00000181615.3 ENSMUST00000181615.4 ENSMUST00000181615.5 ENSMUST00000181615.6 ENSMUST00000181615.7 Gm4340 M0QWS9 M0QWS9_MOUSE NM_001177535 uc057kjx.1 uc057kjx.2 molecular_function nucleic acid binding RNA binding cellular_component biological_process uc057kjx.1 uc057kjx.2 
ENSMUST00000181617.2 Gm17540 ENSMUST00000181617.2 Gm17540 (from geneSymbol) AK142431 ENSMUST00000181617.1 uc009ozs.1 uc009ozs.2 uc009ozs.1 uc009ozs.2 
ENSMUST00000181618.3 6530411M01Rik ENSMUST00000181618.3 RIKEN cDNA 6530411M01 gene (from RefSeq NR_027881.1) ENSMUST00000181618.1 ENSMUST00000181618.2 NR_027881 uc012aju.1 uc012aju.2 uc012aju.3 uc012aju.4 uc012aju.1 uc012aju.2 uc012aju.3 uc012aju.4 
ENSMUST00000181621.4 Snora43 ENSMUST00000181621.4 small nucleolar RNA, H/ACA box 43 (from RefSeq NR_028572.1) ENSMUST00000181621.1 ENSMUST00000181621.2 ENSMUST00000181621.3 NR_028572 uc012bso.1 uc012bso.2 uc012bso.3 uc012bso.1 uc012bso.2 uc012bso.3 
ENSMUST00000181628.8 Slco1a8 ENSMUST00000181628.8 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt M0QWR8) ENSMUST00000181628.1 ENSMUST00000181628.2 ENSMUST00000181628.3 ENSMUST00000181628.4 ENSMUST00000181628.5 ENSMUST00000181628.6 ENSMUST00000181628.7 Gm6614 M0QWR8 M0QWR8_MOUSE Slco1a8 uc291jzy.1 uc291jzy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the organo anion transporter (TC 2.A.60) family. Lacks conserved residue(s) required for the propagation of feature annotation. plasma membrane integral component of plasma membrane ion transport bile acid transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity bile acid and bile salt transport membrane integral component of membrane sodium-independent organic anion transport transmembrane transport uc291jzy.1 uc291jzy.2 
ENSMUST00000181629.2 4930550C17Rik ENSMUST00000181629.2 RIKEN cDNA 4930550C17 gene (from RefSeq NR_131023.1) ENSMUST00000181629.1 NR_131023 uc056ytv.1 uc056ytv.2 uc056ytv.1 uc056ytv.2 
ENSMUST00000181634.8 Alyreffm11 ENSMUST00000181634.8 predicted gene, 21293 (from RefSeq NM_001270898.1) ENSMUST00000181634.1 ENSMUST00000181634.2 ENSMUST00000181634.3 ENSMUST00000181634.4 ENSMUST00000181634.5 ENSMUST00000181634.6 ENSMUST00000181634.7 Gm20765 Gm21293 Gm21304 Gm21312 Gm6763 Gm8764 M0QWB2 M0QWR4 M0QWR4_MOUSE NM_001270898 uc057kjo.1 uc057kjo.2 uc057kjo.3 nucleic acid binding RNA binding uc057kjo.1 uc057kjo.2 uc057kjo.3 
ENSMUST00000181637.2 Gm26600 ENSMUST00000181637.2 Gm26600 (from geneSymbol) AK085302 ENSMUST00000181637.1 uc291mmr.1 uc291mmr.2 uc291mmr.1 uc291mmr.2 
ENSMUST00000181639.3 ENSMUSG00000121824 ENSMUST00000181639.3 ENSMUSG00000121824 (from geneSymbol) ENSMUST00000181639.1 ENSMUST00000181639.2 uc292fsa.1 uc292fsa.2 uc292fsa.1 uc292fsa.2 
ENSMUST00000181648.3 Gm26597 ENSMUST00000181648.3 predicted gene, 26597, transcript variant 1 (from RefSeq NR_165432.1) ENSMUST00000181648.1 ENSMUST00000181648.2 NR_165432 uc291bvm.1 uc291bvm.2 uc291bvm.3 uc291bvm.1 uc291bvm.2 uc291bvm.3 
ENSMUST00000181652.9 Gm10267 ENSMUST00000181652.9 predicted gene 10267 (from RefSeq NM_001281470.1) ENSMUST00000181652.1 ENSMUST00000181652.2 ENSMUST00000181652.3 ENSMUST00000181652.4 ENSMUST00000181652.5 ENSMUST00000181652.6 ENSMUST00000181652.7 ENSMUST00000181652.8 Gm10267 M0QWD8 M0QWD8_MOUSE NM_001281470 uc033hgr.1 uc033hgr.2 uc033hgr.3 uc033hgr.4 uc033hgr.1 uc033hgr.2 uc033hgr.3 uc033hgr.4 
ENSMUST00000181653.2 Gm26850 ENSMUST00000181653.2 Gm26850 (from geneSymbol) AK052681 ENSMUST00000181653.1 uc290fqh.1 uc290fqh.2 uc290fqh.1 uc290fqh.2 
ENSMUST00000181655.3 A230028O05Rik ENSMUST00000181655.3 RIKEN cDNA A230028O05 gene (from RefSeq NR_040374.1) ENSMUST00000181655.1 ENSMUST00000181655.2 NR_040374 uc007yuk.1 uc007yuk.2 uc007yuk.3 uc007yuk.1 uc007yuk.2 uc007yuk.3 
ENSMUST00000181656.2 Gm26579 ENSMUST00000181656.2 predicted gene, 26579 (from RefSeq NR_152731.1) ENSMUST00000181656.1 NR_152731 uc007hcg.1 uc007hcg.2 uc007hcg.1 uc007hcg.2 
ENSMUST00000181660.8 Pantr1 ENSMUST00000181660.8 Pantr1 (from geneSymbol) BC094545 ENSMUST00000181660.1 ENSMUST00000181660.2 ENSMUST00000181660.3 ENSMUST00000181660.4 ENSMUST00000181660.5 ENSMUST00000181660.6 ENSMUST00000181660.7 uc287hqx.1 uc287hqx.2 uc287hqx.1 uc287hqx.2 
ENSMUST00000181666.2 Gm26784 ENSMUST00000181666.2 Gm26784 (from geneSymbol) ENSMUST00000181666.1 uc292dps.1 uc292dps.2 uc292dps.1 uc292dps.2 
ENSMUST00000181667.2 Gm805 ENSMUST00000181667.2 predicted gene 805 (from RefSeq NR_046081.1) ENSMUST00000181667.1 NR_046081 uc007ohq.1 uc007ohq.2 uc007ohq.3 uc007ohq.1 uc007ohq.2 uc007ohq.3 
ENSMUST00000181680.2 A430110L20Rik ENSMUST00000181680.2 A430110L20Rik (from geneSymbol) ENSMUST00000181680.1 LF193062 uc287ong.1 uc287ong.2 uc287ong.1 uc287ong.2 
ENSMUST00000181689.2 Gm26756 ENSMUST00000181689.2 Gm26756 (from geneSymbol) AK039080 ENSMUST00000181689.1 uc290wcc.1 uc290wcc.2 uc290wcc.1 uc290wcc.2 
ENSMUST00000181703.8 Alyreffm15 ENSMUST00000181703.8 predicted gene, 20765 (from RefSeq NM_001270644.1) ENSMUST00000181703.1 ENSMUST00000181703.2 ENSMUST00000181703.3 ENSMUST00000181703.4 ENSMUST00000181703.5 ENSMUST00000181703.6 ENSMUST00000181703.7 Gm20765 Gm21293 Gm21304 Gm21312 Gm6763 Gm8764 M0QWB2 M0QWR4 M0QWR4_MOUSE NM_001270644 uc033fsm.1 uc033fsm.2 uc033fsm.3 nucleic acid binding RNA binding uc033fsm.1 uc033fsm.2 uc033fsm.3 
ENSMUST00000181706.8 Foxl2os ENSMUST00000181706.8 forkhead box L2, opposite strand (from RefSeq NR_003248.3) ENSMUST00000181706.1 ENSMUST00000181706.2 ENSMUST00000181706.3 ENSMUST00000181706.4 ENSMUST00000181706.5 ENSMUST00000181706.6 ENSMUST00000181706.7 NR_003248 uc009rdq.1 uc009rdq.2 uc009rdq.3 uc009rdq.4 uc009rdq.1 uc009rdq.2 uc009rdq.3 uc009rdq.4 
ENSMUST00000181727.3 Gm26531 ENSMUST00000181727.3 Gm26531 (from geneSymbol) AK139642 ENSMUST00000181727.1 ENSMUST00000181727.2 uc288iah.1 uc288iah.2 uc288iah.1 uc288iah.2 
ENSMUST00000181728.3 Trav7-4 ENSMUST00000181728.3 Trav7-4 (from geneSymbol) A0A075B6C1 A0A075B6C1_MOUSE ENSMUST00000181728.1 ENSMUST00000181728.2 Trav7-4 X56701 uc029sjw.1 uc029sjw.2 uc029sjw.3 uc029sjw.4 uc029sjw.5 uc029sjw.1 uc029sjw.2 uc029sjw.3 uc029sjw.4 uc029sjw.5 
ENSMUST00000181738.2 Gm4651 ENSMUST00000181738.2 predicted gene 4651 (from RefSeq NR_138098.1) ENSMUST00000181738.1 NR_138098 uc291imf.1 uc291imf.2 uc291imf.1 uc291imf.2 
ENSMUST00000181746.2 9230116N13Rik ENSMUST00000181746.2 RIKEN cDNA 9230116N13 gene (from RefSeq NR_024328.1) ENSMUST00000181746.1 NR_024328 uc007cus.1 uc007cus.2 uc007cus.1 uc007cus.2 
ENSMUST00000181748.2 Tcstv2a ENSMUST00000181748.2 2 cell stage variable group member 2A, transcript variant 1 (from RefSeq NM_199060.2) AF067061 ENSMUST00000181748.1 NM_199060 O70616 O70616_MOUSE uc029sdy.1 uc029sdy.2 uc029sdy.3 uc029sdy.4 uc029sdy.1 uc029sdy.2 uc029sdy.3 uc029sdy.4 
ENSMUST00000181755.2 1700054K02Rik ENSMUST00000181755.2 1700054K02Rik (from geneSymbol) AK018860 ENSMUST00000181755.1 uc287kmc.1 uc287kmc.2 uc287kmc.1 uc287kmc.2 
ENSMUST00000181762.2 Gm26638 ENSMUST00000181762.2 Gm26638 (from geneSymbol) ENSMUST00000181762.1 uc291dso.1 uc291dso.2 uc291dso.1 uc291dso.2 
ENSMUST00000181767.8 Zfp87 ENSMUST00000181767.8 zinc finger protein 87 (from RefSeq NM_133228.3) ENSMUST00000181767.1 ENSMUST00000181767.2 ENSMUST00000181767.3 ENSMUST00000181767.4 ENSMUST00000181767.5 ENSMUST00000181767.6 ENSMUST00000181767.7 NM_133228 Q8K2A4 Q8K2A4_MOUSE Zfp87 uc007rba.1 uc007rba.2 uc007rba.3 uc007rba.4 uc007rba.5 May be involved in transcriptional regulation. molecular_function nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc007rba.1 uc007rba.2 uc007rba.3 uc007rba.4 uc007rba.5 
ENSMUST00000181768.3 Trav3-3 ENSMUST00000181768.3 Trav3-3 (from geneSymbol) AK134087 ENSMUST00000181768.1 ENSMUST00000181768.2 Q5R1C3 Q5R1C3_MOUSE TRAV3-3 Trav3-3 uc056ywq.1 uc056ywq.2 uc056ywq.3 uc056ywq.4 molecular_function cellular_component biological_process uc056ywq.1 uc056ywq.2 uc056ywq.3 uc056ywq.4 
ENSMUST00000181778.2 Gm26878 ENSMUST00000181778.2 Gm26878 (from geneSymbol) AK086813 ENSMUST00000181778.1 uc292dov.1 uc292dov.2 uc292dov.1 uc292dov.2 
ENSMUST00000181786.2 Gm3629 ENSMUST00000181786.2 predicted gene 3629, transcript variant 3 (from RefSeq NM_001374235.1) ENSMUST00000181786.1 Gm3629 J3QPM5 J3QPM5_MOUSE NM_001374235 uc288qox.1 uc288qox.2 molecular_function cellular_component biological_process uc288qox.1 uc288qox.2 
ENSMUST00000181793.3 Trav6n-6 ENSMUST00000181793.3 Trav6n-6 (from geneSymbol) A0A075B6B2 A0A075B6B2_MOUSE ENSMUST00000181793.1 ENSMUST00000181793.2 M16676 Trav6n-6 uc007tra.1 uc007tra.2 uc007tra.3 immunoglobulin production extracellular space immune response uc007tra.1 uc007tra.2 uc007tra.3 
ENSMUST00000181794.3 Gm26907 ENSMUST00000181794.3 Gm26907 (from geneSymbol) AK015631 ENSMUST00000181794.1 ENSMUST00000181794.2 uc292jea.1 uc292jea.2 uc292jea.1 uc292jea.2 
ENSMUST00000181800.4 1110046J04Rik ENSMUST00000181800.4 1110046J04Rik (from geneSymbol) AK004186 ENSMUST00000181800.1 ENSMUST00000181800.2 ENSMUST00000181800.3 uc007qar.1 uc007qar.2 uc007qar.3 uc007qar.4 uc007qar.1 uc007qar.2 uc007qar.3 uc007qar.4 
ENSMUST00000181801.2 Gm9918 ENSMUST00000181801.2 Gm9918 (from geneSymbol) AK082832 EG432988 ENSMUST00000181801.1 Gm9918 Q8BUR5 Q8BUR5_MOUSE uc289brk.1 uc289brk.2 uc289brk.1 uc289brk.2 
ENSMUST00000181802.2 Gm26513 ENSMUST00000181802.2 Gm26513 (from geneSymbol) AK138788 ENSMUST00000181802.1 uc289azu.1 uc289azu.2 uc289azu.1 uc289azu.2 
ENSMUST00000181803.3 Gm4755 ENSMUST00000181803.3 Gm4755 (from geneSymbol) AK089512 ENSMUST00000181803.1 ENSMUST00000181803.2 uc007nab.1 uc007nab.2 uc007nab.3 uc007nab.1 uc007nab.2 uc007nab.3 
ENSMUST00000181810.8 Tnfsf12 ENSMUST00000181810.8 tumor necrosis factor (ligand) superfamily, member 12 (from RefSeq NM_011614.3) ENSMUST00000181810.1 ENSMUST00000181810.2 ENSMUST00000181810.3 ENSMUST00000181810.4 ENSMUST00000181810.5 ENSMUST00000181810.6 ENSMUST00000181810.7 NM_011614 Q5F2A0 Q5F2A0_MOUSE Tnfsf12 uc007jri.1 uc007jri.2 uc007jri.3 uc007jri.4 Secreted Belongs to the tumor necrosis factor family. tumor necrosis factor receptor binding immune response membrane positive regulation of protein catabolic process perinuclear region of cytoplasm positive regulation of extrinsic apoptotic signaling pathway uc007jri.1 uc007jri.2 uc007jri.3 uc007jri.4 
ENSMUST00000181812.3 Gm16853 ENSMUST00000181812.3 predicted gene, 16853 (from RefSeq NR_045742.1) ENSMUST00000181812.1 ENSMUST00000181812.2 NR_045742 uc029wxs.1 uc029wxs.2 uc029wxs.3 uc029wxs.1 uc029wxs.2 uc029wxs.3 
ENSMUST00000181819.3 Gm16740 ENSMUST00000181819.3 predicted gene, 16740 (from RefSeq NR_108026.1) ENSMUST00000181819.1 ENSMUST00000181819.2 NR_108026 uc008qis.1 uc008qis.2 uc008qis.3 uc008qis.1 uc008qis.2 uc008qis.3 
ENSMUST00000181820.3 4930505N22Rik ENSMUST00000181820.3 RIKEN cDNA 4930505N22 gene (from RefSeq NR_152221.1) ENSMUST00000181820.1 ENSMUST00000181820.2 NR_152221 uc289sfb.1 uc289sfb.2 uc289sfb.3 uc289sfb.1 uc289sfb.2 uc289sfb.3 
ENSMUST00000181827.4 Gm26713 ENSMUST00000181827.4 Gm26713 (from geneSymbol) ENSMUST00000181827.1 ENSMUST00000181827.2 ENSMUST00000181827.3 EU234034 uc292jdv.1 uc292jdv.2 uc292jdv.1 uc292jdv.2 
ENSMUST00000181835.2 4933408J17Rik ENSMUST00000181835.2 RIKEN cDNA 4933408J17 gene (from RefSeq NR_045810.1) ENSMUST00000181835.1 NR_045810 uc029ren.1 uc029ren.2 uc029ren.1 uc029ren.2 
ENSMUST00000181842.2 D430018E03Rik ENSMUST00000181842.2 D430018E03Rik (from geneSymbol) ENSMUST00000181842.1 uc291bko.1 uc291bko.2 uc291bko.1 uc291bko.2 
ENSMUST00000181846.3 1500012K07Rik ENSMUST00000181846.3 RIKEN cDNA 1500012K07 gene, transcript variant 1 (from RefSeq NR_045814.1) ENSMUST00000181846.1 ENSMUST00000181846.2 NR_045814 uc291rmn.1 uc291rmn.2 uc291rmn.1 uc291rmn.2 
ENSMUST00000181851.2 Gm26651 ENSMUST00000181851.2 predicted gene, 26651, transcript variant 2 (from RefSeq NR_188790.1) ENSMUST00000181851.1 NR_188790 uc288mvi.1 uc288mvi.2 uc288mvi.1 uc288mvi.2 
ENSMUST00000181854.2 D630002J18Rik ENSMUST00000181854.2 D630002J18Rik (from geneSymbol) AK052598 ENSMUST00000181854.1 uc290kok.1 uc290kok.2 uc290kok.1 uc290kok.2 
ENSMUST00000181860.8 Car1 ENSMUST00000181860.8 carbonic anhydrase 1, transcript variant 1 (from RefSeq NM_009799.4) CAH1_MOUSE Ca1 ENSMUST00000181860.1 ENSMUST00000181860.2 ENSMUST00000181860.3 ENSMUST00000181860.4 ENSMUST00000181860.5 ENSMUST00000181860.6 ENSMUST00000181860.7 NM_009799 P13634 Q3TS19 Q9DC84 uc008oqq.1 uc008oqq.2 uc008oqq.3 Catalyzes the reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Evidence=; Reaction=urea = cyanamide + H2O; Xref=Rhea:RHEA:23056, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:16698; EC=4.2.1.69; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Inhibited by acetazolamide. Cytoplasm Belongs to the alpha-carbonic anhydrase family. arylesterase activity carbonate dehydratase activity cytoplasm one-carbon metabolic process zinc ion binding lyase activity hydro-lyase activity metal ion binding uc008oqq.1 uc008oqq.2 uc008oqq.3 
ENSMUST00000181875.3 4930478K11Rik ENSMUST00000181875.3 4930478K11Rik (from geneSymbol) AK019647 ENSMUST00000181875.1 ENSMUST00000181875.2 uc288jbg.1 uc288jbg.2 uc288jbg.3 uc288jbg.1 uc288jbg.2 uc288jbg.3 
ENSMUST00000181876.2 Gm26574 ENSMUST00000181876.2 Gm26574 (from geneSymbol) AK143393 ENSMUST00000181876.1 uc287oxa.1 uc287oxa.2 uc287oxa.1 uc287oxa.2 
ENSMUST00000181877.3 Gm26676 ENSMUST00000181877.3 predicted gene, 26676 (from RefSeq NR_188893.1) ENSMUST00000181877.1 ENSMUST00000181877.2 NR_188893 uc289ptn.1 uc289ptn.2 uc289ptn.1 uc289ptn.2 
ENSMUST00000181885.2 Gm26805 ENSMUST00000181885.2 Gm26805 (from geneSymbol) AK039030 ENSMUST00000181885.1 uc007asg.1 uc007asg.2 uc007asg.1 uc007asg.2 
ENSMUST00000181886.2 Gm26862 ENSMUST00000181886.2 Gm26862 (from geneSymbol) AK032083 ENSMUST00000181886.1 uc291ssc.1 uc291ssc.2 uc291ssc.1 uc291ssc.2 
ENSMUST00000181889.2 Gm26726 ENSMUST00000181889.2 Gm26726 (from geneSymbol) ENSMUST00000181889.1 uc292ora.1 uc292ora.2 uc292ora.1 uc292ora.2 
ENSMUST00000181892.9 Zfp748 ENSMUST00000181892.9 zinc finger protein 748, transcript variant 2 (from RefSeq NM_001401856.1) ENSMUST00000181892.1 ENSMUST00000181892.2 ENSMUST00000181892.3 ENSMUST00000181892.4 ENSMUST00000181892.5 ENSMUST00000181892.6 ENSMUST00000181892.7 ENSMUST00000181892.8 NM_001401856 Q7TPL6 Q7TPL6_MOUSE Zfp748 uc007rbb.1 uc007rbb.2 uc007rbb.3 uc007rbb.4 May be involved in transcriptional regulation. negative regulation of transcription from RNA polymerase II promoter nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated protein binding, bridging metal ion binding uc007rbb.1 uc007rbb.2 uc007rbb.3 uc007rbb.4 
ENSMUST00000181893.9 D430036J16Rik ENSMUST00000181893.9 RIKEN cDNA D430036J16 gene, transcript variant 3 (from RefSeq NR_040395.1) ENSMUST00000181893.1 ENSMUST00000181893.2 ENSMUST00000181893.3 ENSMUST00000181893.4 ENSMUST00000181893.5 ENSMUST00000181893.6 ENSMUST00000181893.7 ENSMUST00000181893.8 NR_040395 uc009qvn.1 uc009qvn.2 uc009qvn.3 uc009qvn.4 uc009qvn.5 uc009qvn.1 uc009qvn.2 uc009qvn.3 uc009qvn.4 uc009qvn.5 
ENSMUST00000181904.3 Cxxc4 ENSMUST00000181904.3 CXXC finger 4 (from RefSeq NM_001004367.4) Cxxc4 ENSMUST00000181904.1 ENSMUST00000181904.2 M0QWU0 M0QWU0_MOUSE NM_001004367 uc008rkw.1 uc008rkw.2 uc008rkw.3 uc008rkw.4 uc008rkw.5 Cytoplasm DNA binding zinc ion binding uc008rkw.1 uc008rkw.2 uc008rkw.3 uc008rkw.4 uc008rkw.5 
ENSMUST00000181906.5 Cep83os ENSMUST00000181906.5 Cep83os (from geneSymbol) AK016525 ENSMUST00000181906.1 ENSMUST00000181906.2 ENSMUST00000181906.3 ENSMUST00000181906.4 uc007gvv.1 uc007gvv.2 uc007gvv.3 uc007gvv.4 uc007gvv.5 uc007gvv.6 uc007gvv.1 uc007gvv.2 uc007gvv.3 uc007gvv.4 uc007gvv.5 uc007gvv.6 
ENSMUST00000181910.2 9930014A18Rik ENSMUST00000181910.2 9930014A18Rik (from geneSymbol) AK036813 ENSMUST00000181910.1 uc011ztf.1 uc011ztf.2 uc011ztf.3 uc011ztf.1 uc011ztf.2 uc011ztf.3 
ENSMUST00000181911.3 Gm26827 ENSMUST00000181911.3 Gm26827 (from geneSymbol) ENSMUST00000181911.1 ENSMUST00000181911.2 uc291rbi.1 uc291rbi.2 uc291rbi.1 uc291rbi.2 
ENSMUST00000181912.3 4930525G20Rik ENSMUST00000181912.3 RIKEN cDNA 4930525G20 gene (from RefSeq NR_045194.1) ENSMUST00000181912.1 ENSMUST00000181912.2 NR_045194 uc007rbp.1 uc007rbp.2 uc007rbp.3 uc007rbp.1 uc007rbp.2 uc007rbp.3 
ENSMUST00000181913.2 Gm10532 ENSMUST00000181913.2 predicted gene 10532 (from RefSeq NR_045879.1) ENSMUST00000181913.1 NR_045879 uc029tqc.1 uc029tqc.2 uc029tqc.1 uc029tqc.2 
ENSMUST00000181921.4 B230217O12Rik ENSMUST00000181921.4 RIKEN cDNA B230217O12 gene (from RefSeq NR_040316.1) ENSMUST00000181921.1 ENSMUST00000181921.2 ENSMUST00000181921.3 NR_040316 uc008iab.1 uc008iab.2 uc008iab.3 uc008iab.4 uc008iab.5 uc008iab.6 uc008iab.1 uc008iab.2 uc008iab.3 uc008iab.4 uc008iab.5 uc008iab.6 
ENSMUST00000181925.2 Gm26648 ENSMUST00000181925.2 Gm26648 (from geneSymbol) AK019847 ENSMUST00000181925.1 uc290tsy.1 uc290tsy.2 uc290tsy.1 uc290tsy.2 
ENSMUST00000181931.3 Gm10524 ENSMUST00000181931.3 Gm10524 (from geneSymbol) AK147472 ENSMUST00000181931.1 ENSMUST00000181931.2 uc289pvc.1 uc289pvc.2 uc289pvc.1 uc289pvc.2 
ENSMUST00000181932.2 B230322F03Rik ENSMUST00000181932.2 B230322F03Rik (from geneSymbol) AK045908 ENSMUST00000181932.1 uc291onp.1 uc291onp.2 uc291onp.1 uc291onp.2 
ENSMUST00000181941.2 Gm26696 ENSMUST00000181941.2 Gm26696 (from geneSymbol) ENSMUST00000181941.1 uc291cib.1 uc291cib.2 uc291cib.1 uc291cib.2 
ENSMUST00000181943.4 Gm54719 ENSMUST00000181943.4 Gm54719 (from geneSymbol) AK043339 ENSMUST00000181943.1 ENSMUST00000181943.2 ENSMUST00000181943.3 uc291eem.1 uc291eem.2 uc291eem.3 uc291eem.1 uc291eem.2 uc291eem.3 
ENSMUST00000181951.2 Gm26686 ENSMUST00000181951.2 Gm26686 (from geneSymbol) AK029879 ENSMUST00000181951.1 uc287llu.1 uc287llu.2 uc287llu.1 uc287llu.2 
ENSMUST00000181952.2 Gm26691 ENSMUST00000181952.2 Gm26691 (from geneSymbol) AK034519 ENSMUST00000181952.1 uc008rks.1 uc008rks.2 uc008rks.3 uc008rks.1 uc008rks.2 uc008rks.3 
ENSMUST00000181962.2 Gm16712 ENSMUST00000181962.2 predicted gene, 16712 (from RefSeq NR_108021.1) ENSMUST00000181962.1 NR_108021 uc033heo.1 uc033heo.2 uc033heo.3 uc033heo.1 uc033heo.2 uc033heo.3 
ENSMUST00000181985.8 Sbp ENSMUST00000181985.8 spermine binding protein, transcript variant 3 (from RefSeq NM_001384094.1) ENSMUST00000181985.1 ENSMUST00000181985.2 ENSMUST00000181985.3 ENSMUST00000181985.4 ENSMUST00000181985.5 ENSMUST00000181985.6 ENSMUST00000181985.7 NM_001384094 Q544L5 Q544L5_MOUSE Sbp uc289hvw.1 uc289hvw.2 uc289hvw.1 uc289hvw.2 
ENSMUST00000181996.2 Gm26952 ENSMUST00000181996.2 Gm26952 (from geneSymbol) ENSMUST00000181996.1 uc292pwh.1 uc292pwh.2 uc292pwh.1 uc292pwh.2 
ENSMUST00000181998.8 Plekha7 ENSMUST00000181998.8 pleckstrin homology domain containing, family A member 7, transcript variant 7 (from RefSeq NM_001405070.1) B6RSP2 B6RSP3 ENSMUST00000181998.1 ENSMUST00000181998.2 ENSMUST00000181998.3 ENSMUST00000181998.4 ENSMUST00000181998.5 ENSMUST00000181998.6 ENSMUST00000181998.7 Hadp1 NM_001405070 PKHA7_MOUSE Q3TUE4 Q3UIL6 Q5XG70 Q8BYE3 uc009jiz.1 uc009jiz.2 uc009jiz.3 uc009jiz.4 uc009jiz.5 Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (By similarity). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). Interacts with CAMSAP3 and CTNND1 (By similarity). Interacts (via WW domains) with TSPAN33 (via cytoplasmic domain) and with PDZD11; the interaction with TSPAN33 is dependent on PDZD11 being bound to PLEKHA7 and facilitates the docking of ADAM10 to zonula adherens through interaction of TSPAN33 with ADAM10 (PubMed:30463011). Cell junction, adherens junction Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes to zonula adherens, recruited via its interaction with CTNND1. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q3UIL6-1; Sequence=Displayed; Name=2; Synonyms=HADP1a; IsoId=Q3UIL6-2; Sequence=VSP_025596; Name=3; IsoId=Q3UIL6-3; Sequence=VSP_025595; Name=4; IsoId=Q3UIL6-4; Sequence=VSP_025593, VSP_025596; Name=5; IsoId=Q3UIL6-5; Sequence=VSP_044626, VSP_044627; Name=6; Synonyms=HADP1b; IsoId=Q3UIL6-6; Sequence=VSP_039544, VSP_025596; Expressed in kidney and lung (at protein level). Sequence=BAE36027.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE36027.1; Type=Frameshift; Evidence=; protein binding nucleus cytoplasm centrosome microtubule organizing center cytosol cytoskeleton cell-cell junction adherens junction zonula adherens cell junction cell-cell adhesion mediated by cadherin zonula adherens maintenance pore complex pore complex assembly delta-catenin binding epithelial cell-cell adhesion uc009jiz.1 uc009jiz.2 uc009jiz.3 uc009jiz.4 uc009jiz.5 
ENSMUST00000182006.4 Iqschfp ENSMUST00000182006.4 Iqcj and Schip1 fusion protein (from RefSeq NM_001113419.2) A0A088MLT8 A8IJC6 A8IJD0 A8IJD3 ENSMUST00000182006.1 ENSMUST00000182006.2 ENSMUST00000182006.3 F6YL02 F8WI70 IQIP1_MOUSE Iqcj-Schip1 Iqschfp NM_001113419 Q3TI53 Q52KH1 Q6P9Y8 Q9CX07 Q9JLR0 Schip1 uc012cqg.1 uc012cqg.2 uc012cqg.3 This locus represents naturally occurring read-through transcription from the neighboring IQ motif containing J (Iqcj) and schwannomin interacting protein 1 (Schip1) genes. This locus produces a transcript that is composed of in-frame exons from each individual gene. The resulting fusion protein is thought to be a component of the multimolecular complexes of axon initial segments and nodes of Ranvier, and it may play a role in calcium-mediated responses. [provided by RefSeq, Oct 2010]. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: EU163409.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 30953, 208426 ##RefSeq-Attributes-END## May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25953347, PubMed:25950943, PubMed:27979964). May also play a role in axon outgrowth and guidance (PubMed:25953347). Homooligomer (via coiled coil domain) (PubMed:27979964). Interacts (via IQ domain) with calmodulin; the interaction is direct and lost in presence of calcium (PubMed:18550753). Interacts with ANK3 (via ANK repeats); required for its localization at axon initial segments (AIS) and nodes of Ranvier (PubMed:18550753). Interacts with SPTBN4 (PubMed:27979964). Interacts with KCNQ2 and KCNQ3 (PubMed:27979964). Cell projection, axon Cytoplasm Note=Localizes to the axon initial segments (AIS) and nodes of Ranvier of neurons and is absent from dendrites. Event=Alternative splicing; Named isoforms=7; Name=Iqcj-schip1-1; Synonyms=IQCJ-SCHIP-1 ; IsoId=A0A088MLT8-1; Sequence=Displayed; Name=Iqcj-schip1-2; IsoId=A0A088MLT8-2; Sequence=VSP_059226; Name=Iqcj-1; IsoId=Q8BPW0-1; Sequence=External; Name=Schip1-1; Synonyms=Schip-1a; IsoId=P0DPB4-1, Q3TI53-5; Sequence=External; Name=Schip1-2; IsoId=P0DPB4-2, Q3TI53-1; Sequence=External; Name=Schip1-3; IsoId=P0DPB4-3, Q3TI53-3; Sequence=External; Name=Schip1-4; Synonyms=Schip-1b; IsoId=P0DPB4-4, Q3TI53-6; Sequence=External; Mice lacking all isoforms encoded by both Schip1 and Iqcj-Schip1 are fertile and survive as long as wild-type mice. However, they exhibit mild growth delay associated with ataxia and reduced pain sensitivity. They display decreased thickness of the piriform cortex and partial agenesis of the anterior comissure which could be due to impaired axon elongation and guidance. The morphology of nodes of Ranvier is affected but nerves do not exhibit significant electrophysiological characteristic differences. A reduction in the number of axonal projections in the peripheral nerve system is also observed. [Isoform Iqcj-schip1-1]: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein. [Isoform Iqcj-schip1-2]: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein. protein binding calmodulin binding cytoplasm axon ensheathment axon ankyrin binding node of Ranvier cell projection axon initial segment ion channel binding negative regulation of cytoskeleton organization dendrite uc012cqg.1 uc012cqg.2 uc012cqg.3 
ENSMUST00000182014.10 Sftpb ENSMUST00000182014.10 surfactant associated protein B, transcript variant 1 (from RefSeq NM_147779.3) ENSMUST00000182014.1 ENSMUST00000182014.2 ENSMUST00000182014.3 ENSMUST00000182014.4 ENSMUST00000182014.5 ENSMUST00000182014.6 ENSMUST00000182014.7 ENSMUST00000182014.8 ENSMUST00000182014.9 NM_147779 S4R239 S4R239_MOUSE Sftpb uc291ftf.1 uc291ftf.2 Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. Homodimer; disulfide-linked. Secreted, extracellular space, surface film lysosome lipid metabolic process sphingolipid metabolic process uc291ftf.1 uc291ftf.2 
ENSMUST00000182056.8 Baiap3 ENSMUST00000182056.8 BAI1-associated protein 3, transcript variant 2 (from RefSeq NM_001408206.1) BAIP3_MOUSE Baiap3 E9QQ76 ENSMUST00000182056.1 ENSMUST00000182056.2 ENSMUST00000182056.3 ENSMUST00000182056.4 ENSMUST00000182056.5 ENSMUST00000182056.6 ENSMUST00000182056.7 Gm937 Kiaa0734 NM_001408206 Q6RUT4 Q80TT2 S4R1E7 uc012and.1 uc012and.2 Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans- Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (By similarity). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (Probable). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per C2 domain. Interacts with ADGRB1, this interaction is direct. Interacts with endosomal SNARE proteins VAMP3, VAMP4, STX6 and STX16; this interaction is increased in the presence of calcium. Cytoplasm, cytosol Recycling endosome membrane ; Peripheral membrane protein Late endosome membrane ; Peripheral membrane protein Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Cell membrane ; Peripheral membrane protein Note=Rapidly recruited to the plasma membrane and to Golgi structures in response to increased intracellular calcium concentration. Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q80TT2-2; Sequence=Displayed; Name=1; IsoId=Q80TT2-1; Sequence=VSP_061750; Prominently expressed in brain structures including hypothalamus, amygdala, stria terminalis and periaqueductal gray (at protein level). Expressed in nonneuronal tissues, including placenta, lung, pancreas, spleen, and testes. Within placenta, expression is restricted to the syncytiotrophoblasts. Mutant mice are viable, fertile and have overall normal development. Behavioral phenotyping show increased susceptibility to pentylenetetrazole-induced seizures, increased anxiety in females, and benzodiazepine tolerance in males. Belongs to the unc-13 family. Sequence=BAC65640.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; SNARE binding positive regulation of neurotransmitter secretion calcium ion binding phospholipid binding cytoplasm endosome Golgi apparatus cytosol plasma membrane exocytosis G-protein coupled receptor signaling pathway membrane syntaxin binding late endosome membrane regulation of synaptic transmission, GABAergic trans-Golgi network membrane positive regulation of insulin secretion involved in cellular response to glucose stimulus retrograde transport, endosome to Golgi regulation of behavior modulation of synaptic transmission recycling endosome membrane presynapse GABA-ergic synapse regulation of dense core granule exocytosis dense core granule maturation uc012and.1 uc012and.2 
ENSMUST00000182063.3 Gm5493 ENSMUST00000182063.3 Gm5493 (from geneSymbol) AK141778 ENSMUST00000182063.1 ENSMUST00000182063.2 uc289hra.1 uc289hra.2 uc289hra.1 uc289hra.2 
ENSMUST00000182064.9 Ank2 ENSMUST00000182064.9 ankyrin 2, brain, transcript variant 4 (from RefSeq NM_001327938.1) Ank2 ENSMUST00000182064.1 ENSMUST00000182064.2 ENSMUST00000182064.3 ENSMUST00000182064.4 ENSMUST00000182064.5 ENSMUST00000182064.6 ENSMUST00000182064.7 ENSMUST00000182064.8 NM_001327938 S4R2F3 S4R2F3_MOUSE uc290jly.1 uc290jly.2 Cytoplasm, cytoskeleton Membrane signal transduction uc290jly.1 uc290jly.2 
ENSMUST00000182072.3 4930448K20Rik ENSMUST00000182072.3 RIKEN cDNA 4930448K20 gene (from RefSeq NR_004448.2) ENSMUST00000182072.1 ENSMUST00000182072.2 NR_004448 uc012dal.1 uc012dal.2 uc012dal.3 uc012dal.1 uc012dal.2 uc012dal.3 
ENSMUST00000182077.3 Gm3693 ENSMUST00000182077.3 predicted gene 3693 (from RefSeq NR_152198.1) ENSMUST00000182077.1 ENSMUST00000182077.2 NR_152198 uc007oby.1 uc007oby.2 uc007oby.3 uc007oby.1 uc007oby.2 uc007oby.3 
ENSMUST00000182089.2 Gm26992 ENSMUST00000182089.2 Gm26992 (from geneSymbol) AF541962 ENSMUST00000182089.1 Gm26992 S4R1A3 S4R1A3_MOUSE uc292pwi.1 uc292pwi.2 uc292pwi.1 uc292pwi.2 
ENSMUST00000182109.2 Gm19557 ENSMUST00000182109.2 predicted gene, 19557 (from RefSeq NR_045322.1) ENSMUST00000182109.1 NR_045322 uc008hvd.1 uc008hvd.2 uc008hvd.1 uc008hvd.2 
ENSMUST00000182121.2 9530085P06Rik ENSMUST00000182121.2 9530085P06Rik (from geneSymbol) AK020655 ENSMUST00000182121.1 uc292drf.1 uc292drf.2 uc292drf.1 uc292drf.2 
ENSMUST00000182122.8 Zfp236 ENSMUST00000182122.8 zinc finger protein 236, transcript variant 1 (from RefSeq NM_001374229.1) ENSMUST00000182122.1 ENSMUST00000182122.2 ENSMUST00000182122.3 ENSMUST00000182122.4 ENSMUST00000182122.5 ENSMUST00000182122.6 ENSMUST00000182122.7 NM_001374229 S4R299 S4R299_MOUSE Zfp236 uc012bfp.1 uc012bfp.2 uc012bfp.3 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated uc012bfp.1 uc012bfp.2 uc012bfp.3 
ENSMUST00000182143.2 ENSMUSG00000121614 ENSMUST00000182143.2 ENSMUSG00000121614 (from geneSymbol) BC158129 ENSMUST00000182143.1 uc292pxt.1 uc292pxt.2 uc292pxt.1 uc292pxt.2 
ENSMUST00000182145.4 Gm27045 ENSMUST00000182145.4 Gm27045 (from geneSymbol) ENSMUST00000182145.1 ENSMUST00000182145.2 ENSMUST00000182145.3 LF197340 uc292dpw.1 uc292dpw.2 uc292dpw.3 uc292dpw.1 uc292dpw.2 uc292dpw.3 
ENSMUST00000182161.2 Sowahc ENSMUST00000182161.2 sosondowah ankyrin repeat domain family member C (from RefSeq NM_172939.3) Ankrd57 ENSMUST00000182161.1 NM_172939 Q8BWN1 Q8C0J6 SWAHC_MOUSE uc011xed.1 uc011xed.2 uc011xed.3 uc011xed.4 Belongs to the SOWAH family. molecular_function cellular_component biological_process uc011xed.1 uc011xed.2 uc011xed.3 uc011xed.4 
ENSMUST00000182210.4 Gm6600 ENSMUST00000182210.4 Gm6600 (from geneSymbol) AK136154 ENSMUST00000182210.1 ENSMUST00000182210.2 ENSMUST00000182210.3 uc009eio.1 uc009eio.2 uc009eio.3 uc009eio.1 uc009eio.2 uc009eio.3 
ENSMUST00000182214.8 Sbk2 ENSMUST00000182214.8 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; (from UniProt P0C5K1) E9QLZ2 ENSMUST00000182214.1 ENSMUST00000182214.2 ENSMUST00000182214.3 ENSMUST00000182214.4 ENSMUST00000182214.5 ENSMUST00000182214.6 ENSMUST00000182214.7 P0C5K1 SBK2_MOUSE Sgk069 uc291kxn.1 uc291kxn.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily. MAPK cascade nucleotide binding activation of MAPK activity protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity ATP binding cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity signal transduction by protein phosphorylation activation of protein kinase activity uc291kxn.1 uc291kxn.2 
ENSMUST00000182216.2 Gm26995 ENSMUST00000182216.2 Gm26995 (from geneSymbol) AK146140 ENSMUST00000182216.1 uc290yzc.1 uc290yzc.2 uc290yzc.1 uc290yzc.2 
ENSMUST00000182250.2 Gm26982 ENSMUST00000182250.2 Gm26982 (from geneSymbol) AB347183 ENSMUST00000182250.1 uc291hwm.1 uc291hwm.2 uc291hwm.1 uc291hwm.2 
ENSMUST00000182276.3 Dclre1a ENSMUST00000182276.3 DNA cross-link repair 1A, transcript variant 1 (from RefSeq NM_018831.5) Dclre1a ENSMUST00000182276.1 ENSMUST00000182276.2 NM_018831 S4R1N2 S4R1N2_MOUSE S4R1T3 uc029tsy.1 uc029tsy.2 uc029tsy.3 uc029tsy.4 Nucleus Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family. fibrillar center nucleoplasm DNA metabolic process 5'-3' exodeoxyribonuclease activity nucleic acid phosphodiester bond hydrolysis uc029tsy.1 uc029tsy.2 uc029tsy.3 uc029tsy.4 
ENSMUST00000182283.8 Ptprc ENSMUST00000182283.8 protein tyrosine phosphatase receptor type C, transcript variant 2 (from RefSeq NM_011210.5) E9QLT5 ENSMUST00000182283.1 ENSMUST00000182283.2 ENSMUST00000182283.3 ENSMUST00000182283.4 ENSMUST00000182283.5 ENSMUST00000182283.6 ENSMUST00000182283.7 Ly-5 NM_011210 P06800 PTPRC_MOUSE Ptprc Q61812 Q61813 Q61814 Q61815 Q78EF1 S4R1S4 S4R2V1 uc007cvh.1 uc007cvh.2 uc007cvh.3 uc007cvh.4 uc007cvh.5 Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes (By similarity). Binds GANAB and PRKCSH. P06800; P06240: Lck; NbExp=2; IntAct=EBI-1672, EBI-1401; Cell membrane ; Single-pass type I membrane protein Membrane raft Note=Colocalized with DPP4 in membrane rafts. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P06800-4; Sequence=Displayed; Name=2; IsoId=P06800-5; Sequence=VSP_059411; Name=3; IsoId=P06800-6; Sequence=VSP_059410; Expression is restricted to the hematopoietic compartment of development. The first PTPase domain interacts with SKAP1. Heavily N- and O-glycosylated. Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. It is uncertain whether Met-1 or Met-3 is the initiator. Sequence=AAA39458.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAA39459.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAA40161.1; Type=Frameshift; Evidence=; Sequence=AAA40161.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; Sequence=AAA60449.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAB46374.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; activation of MAPK activity natural killer cell differentiation negative regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity negative regulation of cytokine-mediated signaling pathway hematopoietic progenitor cell differentiation immunoglobulin biosynthetic process positive regulation of T cell mediated immunity regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of humoral immune response mediated by circulating immunoglobulin phosphoprotein phosphatase activity protein tyrosine phosphatase activity receptor binding protein binding plasma membrane integral component of plasma membrane focal adhesion negative regulation of protein kinase activity protein dephosphorylation negative regulation of cell adhesion involved in substrate-bound cell migration leukocyte cell-cell adhesion heparin binding external side of plasma membrane cytoplasmic side of plasma membrane cell surface response to gamma radiation regulation of gene expression membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity protein kinase binding B cell differentiation T cell differentiation ankyrin binding spectrin binding positive regulation of B cell proliferation cellular response to extracellular stimulus negative regulation of protein autophosphorylation bleb regulation of interleukin-8 production positive regulation of tumor necrosis factor production heterotypic cell-cell adhesion peptidyl-tyrosine dephosphorylation calcium-mediated signaling using intracellular calcium source T cell proliferation B cell proliferation positive regulation of T cell proliferation heparan sulfate proteoglycan binding positive regulation of MAPK cascade cell cycle phase transition plasma membrane raft distribution positive thymic T cell selection negative thymic T cell selection negative regulation of interleukin-2 biosynthetic process positive regulation of interleukin-2 biosynthetic process membrane raft positive regulation of T cell differentiation positive regulation of gamma-delta T cell differentiation regulation of JAK-STAT cascade positive regulation of alpha-beta T cell proliferation positive regulation of isotype switching to IgG isotypes bone marrow development stem cell development positive regulation of peptidyl-tyrosine phosphorylation negative regulation of peptidyl-tyrosine phosphorylation regulation of phagocytosis T cell receptor signaling pathway B cell receptor signaling pathway positive regulation of antigen receptor-mediated signaling pathway release of sequestered calcium ion into cytosol defense response to virus regulation of cell cycle regulation of protein tyrosine kinase activity negative regulation of protein tyrosine kinase activity negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cell periphery membrane microdomain positive regulation of protein tyrosine phosphatase activity positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of hematopoietic stem cell migration positive regulation of stem cell proliferation regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway uc007cvh.1 uc007cvh.2 uc007cvh.3 uc007cvh.4 uc007cvh.5 
ENSMUST00000182303.2 Gm27028 ENSMUST00000182303.2 Gm27028 (from geneSymbol) ENSMUST00000182303.1 LF192586 uc287gvq.1 uc287gvq.2 uc287gvq.1 uc287gvq.2 
ENSMUST00000182341.8 Ano4 ENSMUST00000182341.8 anoctamin 4, transcript variant 1 (from RefSeq NM_001277188.1) ANO4_MOUSE Ano4 ENSMUST00000182341.1 ENSMUST00000182341.2 ENSMUST00000182341.3 ENSMUST00000182341.4 ENSMUST00000182341.5 ENSMUST00000182341.6 ENSMUST00000182341.7 NM_001277188 Q8C5H1 Q8CA37 Tmem16d uc033frt.1 uc033frt.2 uc033frt.3 Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium- activated chloride channel (CaCC) activity (PubMed:22075693). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38664; Evidence=; Reaction=a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in); Xref=Rhea:RHEA:38899, ChEBI:CHEBI:18390; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38900; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38573; Evidence=; Cell membrane ; Multi-pass membrane protein Note=Shows an intracellular localization according to PubMed:22075693. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C5H1-1; Sequence=Displayed; Name=2 ; IsoId=Q8C5H1-2; Sequence=VSP_052962, VSP_052963; Name=3 ; IsoId=Q8C5H1-3; Sequence=VSP_052960, VSP_052961; Predominantly expressed in neuronal tissues. Expressed at low levels in ovary, uterus, heart and brain. The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. [Isoform 2]: May be due to an intron retention. Belongs to the anoctamin family. plasma membrane chloride transport lipid transport membrane integral component of membrane phospholipid scramblase activity ion transmembrane transport protein dimerization activity calcium activated phospholipid scrambling calcium activated phosphatidylserine scrambling calcium activated phosphatidylcholine scrambling calcium activated galactosylceramide scrambling intracellular calcium activated chloride channel activity uc033frt.1 uc033frt.2 uc033frt.3 
ENSMUST00000182345.2 Gm26984 ENSMUST00000182345.2 Gm26984 (from geneSymbol) ENSMUST00000182345.1 LF220048 uc290gby.1 uc290gby.2 uc290gby.1 uc290gby.2 
ENSMUST00000182350.3 Xcr1 ENSMUST00000182350.3 chemokine (C motif) receptor 1 (from RefSeq NM_011798.4) Ccxcr1 ENSMUST00000182350.1 ENSMUST00000182350.2 NM_011798 Q9R0M1 XCR1_MOUSE uc009sgw.1 uc009sgw.2 uc009sgw.3 Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin (Probable). Cell membrane; Multi-pass membrane protein. Expressed by dendritic cells from the thymus, slpeen, subcutaneous lymph nodes and mesenteric lymph nodes. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity chemokine receptor activity plasma membrane chemotaxis immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration external side of plasma membrane membrane integral component of membrane C-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding response to cytokine release of sequestered calcium ion into cytosol cell chemotaxis chemokine-mediated signaling pathway uc009sgw.1 uc009sgw.2 uc009sgw.3 
ENSMUST00000182352.2 Gm27011 ENSMUST00000182352.2 predicted gene, 27011 (from RefSeq NR_169031.1) ENSMUST00000182352.1 NR_169031 uc057ccs.1 uc057ccs.2 uc057ccs.3 uc057ccs.1 uc057ccs.2 uc057ccs.3 
ENSMUST00000182386.3 Septin14 ENSMUST00000182386.3 septin 14 (from RefSeq NM_028826.2) ENSMUST00000182386.1 ENSMUST00000182386.2 NM_028826 S4R2P6 S4R2P6_MOUSE Sept14 Septin14 uc012edz.1 uc012edz.2 uc012edz.3 Filament-forming cytoskeletal GTPase. Septins polymerize into heterooligomeric protein complexes that form filaments. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. nucleotide binding GTP binding uc012edz.1 uc012edz.2 uc012edz.3 
ENSMUST00000182405.9 Kat6b ENSMUST00000182405.9 K(lysine) acetyltransferase 6B, transcript variant 1 (from RefSeq NM_017479.4) E9QK86 ENSMUST00000182405.1 ENSMUST00000182405.2 ENSMUST00000182405.3 ENSMUST00000182405.4 ENSMUST00000182405.5 ENSMUST00000182405.6 ENSMUST00000182405.7 ENSMUST00000182405.8 KAT6B_MOUSE Myst4 NM_017479 Q7TNW5 Q8BG35 Q8BRB7 Q8C441 Q9JKX5 uc007slg.1 uc007slg.2 uc007slg.3 uc007slg.4 Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2- dependent transcriptional activation. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity). Involved in cerebral cortex development. Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with RUNX1 and RUNX2. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BRB7-1; Sequence=Displayed; Name=2; IsoId=Q8BRB7-2; Sequence=VSP_014592; Ubiquitously expressed. Strongly expressed in the ventricular zone of the developing cerebral cortex. The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression. Autoacetylation at Lys-633 is required for proper function. Mice have a low body weight, craniofacial abnormalities, and defects in cortex development. Mice carrying a gene trap insertion in the gene, produces approximately 5% of the normal amount of mRNA. The hypomorphic mutant displays a number of defects that mirror SBBYSS syndrome, although the phenotype is milder. Mice are of normal size at birth but fail to thrive and have brain developmental defects as well as craniofacial defects. Observed abnormalities include short and narrow palpebral fissures, low set ears, and malocclusion. Similar to individuals with SBBYSS, mice carrying the gene trap insertion have long, slender feet and disproportionally long first digits. Belongs to the MYST (SAS/MOZ) family. Sequence=BAC33305.1; Type=Miscellaneous discrepancy; Note=Probable intron retention.; Evidence=; Sequence=BAC34930.1; Type=Miscellaneous discrepancy; Note=Probable intron retention.; Evidence=; Sequence=BAC38771.1; Type=Miscellaneous discrepancy; Note=Probable intron retention.; Evidence=; histone acetyltransferase complex nucleosome nuclear chromatin DNA binding histone acetyltransferase activity nucleus chromatin organization nucleosome assembly regulation of transcription, DNA-templated transcription factor binding acetyltransferase activity histone acetylation transferase activity transferase activity, transferring acyl groups histone binding histone H3 acetylation macromolecular complex binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding MOZ/MORF histone acetyltransferase complex cellular response to leukemia inhibitory factor uc007slg.1 uc007slg.2 uc007slg.3 uc007slg.4 
ENSMUST00000182423.2 Gm26971 ENSMUST00000182423.2 Gm26971 (from geneSymbol) ENSMUST00000182423.1 LF197332 uc292dnm.1 uc292dnm.2 uc292dnm.1 uc292dnm.2 
ENSMUST00000182453.2 Gm26981 ENSMUST00000182453.2 Gm26981 (from geneSymbol) ENSMUST00000182453.1 uc291srm.1 uc291srm.2 uc291srm.1 uc291srm.2 
ENSMUST00000182477.4 Gm17750 ENSMUST00000182477.4 Gm17750 (from geneSymbol) AK082072 ENSMUST00000182477.1 ENSMUST00000182477.2 ENSMUST00000182477.3 uc007rin.1 uc007rin.2 uc007rin.3 uc007rin.4 uc007rin.5 uc007rin.6 uc007rin.1 uc007rin.2 uc007rin.3 uc007rin.4 uc007rin.5 uc007rin.6 
ENSMUST00000182481.8 Plce1 ENSMUST00000182481.8 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T- cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (By similarity). (from UniProt Q8K4S1) AB076247 B9EHS1 E9Q5G0 ENSMUST00000182481.1 ENSMUST00000182481.2 ENSMUST00000182481.3 ENSMUST00000182481.4 ENSMUST00000182481.5 ENSMUST00000182481.6 ENSMUST00000182481.7 Kiaa1516 PLCE1_MOUSE Plce Plce1 Q3TS68 Q80TC4 Q8BZF3 Q8K4S1 Q9JKM2 uc289rwc.1 uc289rwc.2 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T- cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Activated by the heterotrimeric G-protein subunits GNA12, GNA13 and GNB1-GNG2. Activated by HRAS, RAP1A, RHOA, RHOB, RHOC, RRAS and RRAS2. Activated by the G(s)-coupled GPCRs ADRB2, PTGER1 and CHRM3 through cyclic-AMP formation and RAP2B activation. Inhibited by G(i)-coupled GPCRs (By similarity). Interacts with RHOA (By similarity). Interacts with IQGAP1, HRAS, RAP1A, RAP2A, RAP2B and RRAS (By similarity). Interacts with IQGAP1 (PubMed:17086182). Interacts with AVIL (By similarity). Q8K4S1; E9Q401: Ryr2; NbExp=2; IntAct=EBI-6902760, EBI-643628; Cytoplasm, cytosol Cell membrane Golgi apparatus membrane Cell projection, lamellipodium Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes. Highly expressed in neurons and to a lower extent in skin, skeletal muscle and heart (at protein level). Expressed in the epidermis. Specifically expressed in cells committed to the neuronal lineage (at protein level). Weakly expressed at 7 dpc, expression strongly increases at later embryonic stages. Expressed abundantly in almost all neural tissues at 12.5 dpc and also detected in tongue muscles, genital tubercle and hand plate. At 15.5 dpc a strong expression in skeletal muscles is detected together with the strong expression in neural tissues. Up-regulated during the differentiation of neural precursor cells into neurons but not glial cells. Up-regulated in heart upon induced hypertrophy. The Ras-associating domain 1 is degenerated and may not bind HRAS. The Ras-associating domain 2 mediates interaction with GTP-bound HRAS, RAP1A, RAP2A and RAP2B and recruitment of HRAS to the cell membrane (By similarity). The Ras-GEF domain has a GEF activity towards HRAS and RAP1A. Mediates activation of the mitogen-activated protein kinase pathway (By similarity). Mice exhibit delayed onset and markedly reduced incidence of chemically induced skin squamous tumors. They also display cardiac malformations which mainly affects aortic and pulmonary valves and enhanced susceptibility to cardiac hypertrophy and fibrosis in response to chronic stress. Sequence=BAC29099.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; Golgi membrane activation of MAPK activity phosphatidylinositol phospholipase C activity phospholipase C activity guanyl-nucleotide exchange factor activity protein binding cytoplasm Golgi apparatus cytosol plasma membrane lipid metabolic process signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway small GTPase mediated signal transduction Ras protein signal transduction phosphoric diester hydrolase activity regulation of G-protein coupled receptor protein signaling pathway membrane lipid catabolic process hydrolase activity Ras GTPase binding enzyme binding glomerulus development inositol trisphosphate biosynthetic process intracellular signal transduction regulation of protein kinase activity regulation of Ras protein signal transduction metal ion binding phosphatidylinositol-mediated signaling release of sequestered calcium ion into cytosol uc289rwc.1 uc289rwc.2 
ENSMUST00000182496.2 Gm26918 ENSMUST00000182496.2 Gm26918 (from geneSymbol) ENSMUST00000182496.1 uc290tfy.1 uc290tfy.2 uc290tfy.1 uc290tfy.2 
ENSMUST00000182515.8 Mzf1 ENSMUST00000182515.8 myeloid zinc finger 1, transcript variant 1 (from RefSeq NM_145819.3) A1L358 A1L358_MOUSE ENSMUST00000182515.1 ENSMUST00000182515.2 ENSMUST00000182515.3 ENSMUST00000182515.4 ENSMUST00000182515.5 ENSMUST00000182515.6 ENSMUST00000182515.7 Mzf1 NM_145819 uc009fff.1 uc009fff.2 uc009fff.3 uc009fff.4 Nucleus negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated protein homodimerization activity transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc009fff.1 uc009fff.2 uc009fff.3 uc009fff.4 
ENSMUST00000182559.8 Arhgap12 ENSMUST00000182559.8 Rho GTPase activating protein 12, transcript variant 1 (from RefSeq NM_001039692.1) ENSMUST00000182559.1 ENSMUST00000182559.2 ENSMUST00000182559.3 ENSMUST00000182559.4 ENSMUST00000182559.5 ENSMUST00000182559.6 ENSMUST00000182559.7 NM_001039692 Q8BVP8 Q8C0D4 RHG12_MOUSE uc008dzc.1 uc008dzc.2 uc008dzc.3 uc008dzc.4 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. phagocytic cup morphogenesis of an epithelial sheet molecular_function GTPase activator activity cytoplasm phagocytosis, engulfment actin filament organization signal transduction regulation of GTPase activity positive regulation of GTPase activity negative regulation of small GTPase mediated signal transduction uc008dzc.1 uc008dzc.2 uc008dzc.3 uc008dzc.4 
ENSMUST00000182625.2 Sox12 ENSMUST00000182625.2 SRY (sex determining region Y)-box 12 (from RefSeq NM_011438.2) A2AS82 ENSMUST00000182625.1 NM_011438 P70417 Q04890 Q6NXL2 SOX12_MOUSE Sox-12 uc008nfi.1 uc008nfi.2 uc008nfi.3 uc008nfi.4 Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3' (PubMed:18505825, PubMed:18403418, PubMed:30190287). Acts as a transcriptional activator (PubMed:18505825, PubMed:18403418, PubMed:30190287). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (PubMed:18505825, PubMed:18403418). Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions (PubMed:30190287). Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation (PubMed:30190287). Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (PubMed:20596238). Nucleus Expressed in splenic and thymic regulatory T-cells (at protein level) (PubMed:30190287). Expressed in embryonic molar and incisor teeth (PubMed:8921394). Widely expressed in the developing embryo from 9.5 dpc to 12.5 dpc (PubMed:8441686, PubMed:18505825, PubMed:18403418, PubMed:20596238). Expressed throughout the central and peripheral nervous system, as well as the mesenchyme of many developing organs between 12.5 dpc and 14.5 dpc (PubMed:18403418). Strongly expressed in the lens of the eye, developing cerebral cortex, the dorsal cortical plate, thalamus, hippocampus and cerebellar cortex in the brain at 14.5 dpc (PubMed:18505825). Expressed in skin, spinal cord, lung, liver, intestine, kidney, heart, muscle, cartilage from 14.5 dpc to 18.5 dpc (PubMed:18505825). Abundantly expressed in the brain, heart and lung, with low expression in the liver, pancreas, and small intestine at postnatal day 2 (PubMed:18403418). Induced by T-cell receptor signaling in naive CD4-positive T-cells and in splenic and thymic regulatory T-cells (PubMed:30190287). Up-regulated in splenic T reg cells by dextran sulfate sodium (DSS)- induced colitis (PubMed:30190287). Knockout mice are viable, fertile and morphologically normal (PubMed:18505825, PubMed:20596238). Increased expression of Sox11 in brain and cartilage at 14.5 dpc, with increased expression in liver and kidney at 16.5 dpc (PubMed:18505825). Increased expression of Sox4 in spinal cord and cartilage at 14.5 dpc, with increased expression in liver at 16.5 dpc (PubMed:18505825). Sox12 knockout naive CD4-positive T cells fail to differentiate into pT reg cells in mice with dextran sulfate sodium (DSS)-induced colitis (PubMed:30190287). Sox4, Sox11, and Sox12 triple knockout mice are embryonically lethal and show severe thinning and undulation of the neural tube (PubMed:20596238). transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription coactivator activity nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter spinal cord development cell differentiation protein-DNA complex nuclear transcription factor complex cell fate commitment positive regulation of transcription from RNA polymerase II promoter protein-DNA complex assembly uc008nfi.1 uc008nfi.2 uc008nfi.3 uc008nfi.4 
ENSMUST00000182627.8 Atp13a4 ENSMUST00000182627.8 ATPase type 13A4, transcript variant 1 (from RefSeq NM_001164612.1) Atp13a4 ENSMUST00000182627.1 ENSMUST00000182627.2 ENSMUST00000182627.3 ENSMUST00000182627.4 ENSMUST00000182627.5 ENSMUST00000182627.6 ENSMUST00000182627.7 NM_001164612 S4R234 S4R234_MOUSE uc012aec.1 uc012aec.2 uc012aec.3 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence=; Membrane ulti-pass membrane protein Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. nucleotide binding ATP binding cation transport membrane integral component of membrane hydrolase activity ATPase activity metal ion binding uc012aec.1 uc012aec.2 uc012aec.3 
ENSMUST00000182634.8 Gapdhs ENSMUST00000182634.8 glyceraldehyde-3-phosphate dehydrogenase, spermatogenic, transcript variant 1 (from RefSeq NM_001290631.1) ENSMUST00000182634.1 ENSMUST00000182634.2 ENSMUST00000182634.3 ENSMUST00000182634.4 ENSMUST00000182634.5 ENSMUST00000182634.6 ENSMUST00000182634.7 Gapdhs NM_001290631 S4R2G5 S4R2G5_MOUSE uc009gge.1 uc009gge.2 uc009gge.3 uc009gge.4 uc009gge.5 uc009gge.6 May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility. Reaction=D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3- phospho-glyceroyl phosphate + H(+) + NADH; Xref=Rhea:RHEA:10300, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57540, ChEBI:CHEBI:57604, ChEBI:CHEBI:57945, ChEBI:CHEBI:59776; EC=1.2.1.12; Evidence= Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 1/5. Homotetramer. Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity glucose metabolic process glycolytic process oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor NADP binding NAD binding oxidation-reduction process uc009gge.1 uc009gge.2 uc009gge.3 uc009gge.4 uc009gge.5 uc009gge.6 
ENSMUST00000182652.2 Gm5946 ENSMUST00000182652.2 predicted gene 5946 (from RefSeq NR_183180.1) ENSMUST00000182652.1 NR_183180 uc009uoe.1 uc009uoe.2 uc009uoe.3 uc009uoe.1 uc009uoe.2 uc009uoe.3 
ENSMUST00000182659.8 Rbm5 ENSMUST00000182659.8 RNA binding motif protein 5, transcript variant 1 (from RefSeq NM_148930.3) ENSMUST00000182659.1 ENSMUST00000182659.2 ENSMUST00000182659.3 ENSMUST00000182659.4 ENSMUST00000182659.5 ENSMUST00000182659.6 ENSMUST00000182659.7 Luca15 NM_148930 Q3UZ19 Q91YE7 Q99KV9 RBM5_MOUSE uc009rmx.1 uc009rmx.2 uc009rmx.3 uc009rmx.4 Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity). Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound. Interacts with U2AF2; this interaction is direct. Also interacts with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200; these interactions may be indirect (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91YE7-1; Sequence=Displayed; Name=2; IsoId=Q91YE7-2; Sequence=VSP_021003; Belongs to the RBM5/RBM10 family. spliceosomal complex assembly regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding nucleus nucleoplasm spliceosomal complex mRNA processing apoptotic process RNA splicing regulation of apoptotic process positive regulation of apoptotic process metal ion binding uc009rmx.1 uc009rmx.2 uc009rmx.3 uc009rmx.4 
ENSMUST00000182660.8 Prrc2c ENSMUST00000182660.8 proline-rich coiled-coil 2C (from RefSeq NM_001081290.1) Bat2d Bat2d1 Bat2l2 E9QKG5 ENSMUST00000182660.1 ENSMUST00000182660.2 ENSMUST00000182660.3 ENSMUST00000182660.4 ENSMUST00000182660.5 ENSMUST00000182660.6 ENSMUST00000182660.7 Kiaa1096 NM_001081290 PRC2C_MOUSE Q05CS4 Q05DM5 Q3TKF3 Q3TLH4 Q3UXU5 Q4FZE4 Q66K03 Q6P3F4 Q80TK3 Q80YR0 Q8BMJ4 Q8C1K7 Q8CGH3 uc007dgr.1 uc007dgr.2 uc007dgr.3 Required for efficient formation of stress granules. Cytoplasm, Stress granule Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TLH4-1; Sequence=Displayed; Name=5; IsoId=Q3TLH4-5; Sequence=VSP_035255; Sequence=AAH06723.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH21412.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH37745.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH80672.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=AAH99612.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC25414.1; Type=Frameshift; Evidence=; Sequence=BAC65723.1; Type=Frameshift; Evidence=; Sequence=BAE22468.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; hematopoietic progenitor cell differentiation cytosol protein C-terminus binding uc007dgr.1 uc007dgr.2 uc007dgr.3 
ENSMUST00000182673.2 Scgb2b17 ENSMUST00000182673.2 secretoglobin, family 2B, member 6 (from RefSeq NM_001378690.1) ENSMUST00000182673.1 NM_001378690 S4R2V3 S4R2V3_MOUSE Scgb2b15 Scgb2b17 uc033iyr.1 uc033iyr.2 uc033iyr.3 Belongs to the secretoglobin family. molecular_function cellular_component extracellular space biological_process uc033iyr.1 uc033iyr.2 uc033iyr.3 
ENSMUST00000182677.8 Raet1d ENSMUST00000182677.8 Acts as a ligand for KLRK1. (from UniProt Q9JI58) ENSMUST00000182677.1 ENSMUST00000182677.2 ENSMUST00000182677.3 ENSMUST00000182677.4 ENSMUST00000182677.5 ENSMUST00000182677.6 ENSMUST00000182677.7 NM_009016 Q3KQI0 Q9JI58 RAE1D_MOUSE uc287pzy.1 uc287pzy.2 Acts as a ligand for KLRK1. Cell membrane ; Lipid-anchor, GPI-anchor Expressed predominantly during early embryogenesis. Detected at high levels in 7, 11 and 14-day-old embryos but not in 18-day-old embryos. Very low levels detected in adults. By retinoic acid. Glycosylated. Belongs to the NKG2D ligand family. protein binding extracellular space plasma membrane immune response external side of plasma membrane membrane anchored component of membrane natural killer cell mediated cytotoxicity spanning component of plasma membrane anchored component of plasma membrane natural killer cell lectin-like receptor binding uc287pzy.1 uc287pzy.2 
ENSMUST00000182709.8 Rnf4 ENSMUST00000182709.8 ring finger protein 4, transcript variant 1 (from RefSeq NM_011278.5) ENSMUST00000182709.1 ENSMUST00000182709.2 ENSMUST00000182709.3 ENSMUST00000182709.4 ENSMUST00000182709.5 ENSMUST00000182709.6 ENSMUST00000182709.7 NM_011278 O35941 Q541Z6 Q9QZS2 RNF4_MOUSE Rnf4 uc008xcd.1 uc008xcd.2 uc008xcd.3 uc008xcd.4 This gene encodes a small nuclear RING finger protein that mediates ubiquitylation of polysumoylated proteins. Deficiency of the encoded protein in mice leads to embryonic lethality and global DNA hypermethylation. A similar protein in humans is required for arsenic-induced degradation of promyelocytic leukemia protein in acute promyelocytic leukemia. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 10. [provided by RefSeq, Jan 2015]. E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:20681948). Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (By similarity). Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (By similarity). Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (By similarity). Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (By similarity). Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homodimer (via RING-type zinc finger domain) (PubMed:20681948). Interacts with GSC2 (PubMed:10822263). Interacts with AR/the androgen receptor and TBP (By similarity). Interacts with TCF20 (PubMed:10849425). Interacts with PATZ1 (By similarity). Interacts with TRPS1; negatively regulates TRPS1 transcriptional repressor activity (PubMed:12885770). Interacts with PML (isoform PML- 1, isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6). Interacts with PRDM1/Blimp-1 (By similarity). Cytoplasm Nucleus Nucleus, PML body In the embryo, expressed primarily in the developing nervous system with strong expression in the dorsal root ganglia and gonads (PubMed:10822263, PubMed:9479498). Ubiquitously expressed in the adult (PubMed:10822263, PubMed:9479498). Expression is detected from embryonic day 7 and continues throughout development and into adulthood. The SUMO interaction motifs (SIMs) mediates the binding to polysumoylated substrate. The RING-type zinc finger domain is required for the ubiquitination of polysumoylated substrates. Sumoylated; conjugated by one or two SUMO1 moieties. Autoubiquitinated. DNA binding ubiquitin-protein transferase activity protein binding nucleus nucleoplasm cytoplasm cytosol transcription factor binding zinc ion binding protein ubiquitination PML body transferase activity TBP-class protein binding estrogen receptor binding nucleosome binding ubiquitin conjugating enzyme binding SUMO polymer binding progesterone receptor binding identical protein binding protein homodimerization activity proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to arsenic-containing substance metal ion binding androgen receptor binding protein autoubiquitination negative regulation of cell death ubiquitin protein ligase activity protein K63-linked ubiquitination protein K48-linked ubiquitination protein K11-linked ubiquitination cellular response to testosterone stimulus cellular response to gamma radiation cellular response to hydroxyurea protein K6-linked ubiquitination regulation of spindle assembly regulation of kinetochore assembly uc008xcd.1 uc008xcd.2 uc008xcd.3 uc008xcd.4 
ENSMUST00000182727.2 Gm27010 ENSMUST00000182727.2 Gm27010 (from geneSymbol) ENSMUST00000182727.1 uc288vas.1 uc288vas.2 uc288vas.1 uc288vas.2 
ENSMUST00000182741.2 Cyp2ab1 ENSMUST00000182741.2 Belongs to the cytochrome P450 family. (from UniProt S4R196) AK089408 Cyp2ab1 ENSMUST00000182741.1 S4R196 S4R196_MOUSE uc289djl.1 uc289djl.2 Belongs to the cytochrome P450 family. monooxygenase activity iron ion binding cytoplasm organic acid metabolic process xenobiotic metabolic process steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding exogenous drug catabolic process intracellular membrane-bounded organelle metal ion binding oxidation-reduction process uc289djl.1 uc289djl.2 
ENSMUST00000182746.2 Gm26920 ENSMUST00000182746.2 Gm26920 (from geneSymbol) BC058946 ENSMUST00000182746.1 Gm26920 S4R2A5 S4R2A5_MOUSE uc291nsq.1 uc291nsq.2 nucleic acid binding regulation of transcription, DNA-templated uc291nsq.1 uc291nsq.2 
ENSMUST00000182750.10 Ntn5 ENSMUST00000182750.10 netrin 5, transcript variant 4 (from RefSeq NM_001358870.2) ENSMUST00000182750.1 ENSMUST00000182750.2 ENSMUST00000182750.3 ENSMUST00000182750.4 ENSMUST00000182750.5 ENSMUST00000182750.6 ENSMUST00000182750.7 ENSMUST00000182750.8 ENSMUST00000182750.9 NM_001358870 Ntn5 S4R1X6 S4R1X6_MOUSE uc009gwq.1 uc009gwq.2 uc009gwq.3 uc009gwq.4 extracellular region uc009gwq.1 uc009gwq.2 uc009gwq.3 uc009gwq.4 
ENSMUST00000182753.2 Gm26954 ENSMUST00000182753.2 Gm26954 (from geneSymbol) ENSMUST00000182753.1 uc290tgg.1 uc290tgg.2 uc290tgg.1 uc290tgg.2 
ENSMUST00000182769.10 Casp16 ENSMUST00000182769.10 Casp16 (from geneSymbol) ENSMUST00000182769.1 ENSMUST00000182769.2 ENSMUST00000182769.3 ENSMUST00000182769.4 ENSMUST00000182769.5 ENSMUST00000182769.6 ENSMUST00000182769.7 ENSMUST00000182769.8 ENSMUST00000182769.9 uc289hss.1 uc289hss.2 uc289hss.1 uc289hss.2 
ENSMUST00000182789.3 Gm27002 ENSMUST00000182789.3 Gm27002 (from geneSymbol) ENSMUST00000182789.1 ENSMUST00000182789.2 uc292lyv.1 uc292lyv.2 uc292lyv.3 uc292lyv.1 uc292lyv.2 uc292lyv.3 
ENSMUST00000182839.2 Gm26938 ENSMUST00000182839.2 Membrane ; Multi- pass membrane protein (from UniProt S4R185) BC026659 ENSMUST00000182839.1 Gm26938 S4R185 S4R185_MOUSE uc291bgq.1 uc291bgq.2 Membrane ; Multi- pass membrane protein membrane integral component of membrane early endosome membrane uc291bgq.1 uc291bgq.2 
ENSMUST00000182843.2 Gm26978 ENSMUST00000182843.2 Gm26978 (from geneSymbol) ENSMUST00000182843.1 uc291zgg.1 uc291zgg.2 uc291zgg.1 uc291zgg.2 
ENSMUST00000182858.2 Rassf10 ENSMUST00000182858.2 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 (from RefSeq NM_175279.3) ENSMUST00000182858.1 NM_175279 Q05AF4 Q8BL43 Q8C0D3 Q8K340 RASFA_MOUSE uc009jhb.1 uc009jhb.2 uc009jhb.3 Plays an important role in regulating embryonic neurogenesis. Cytoplasm, cytosol Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Expressed in neural progenitor cells (at protein level). Expression increases from 10 dpc to 12 dpc and gradually decreases after 15 dpc (at protein level). Sequence=AAH28854.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; Sequence=BAC27498.1; Type=Frameshift; Evidence=; Sequence=BAC32726.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; spindle pole molecular_function cellular_component cytoplasm microtubule organizing center cytosol cytoskeleton signal transduction nervous system development positive regulation of neurogenesis positive regulation of neural precursor cell proliferation uc009jhb.1 uc009jhb.2 uc009jhb.3 
ENSMUST00000182863.2 Gm5914 ENSMUST00000182863.2 predicted gene 5914, transcript variant 2 (from RefSeq NR_151743.1) ENSMUST00000182863.1 NR_151743 uc009ndk.1 uc009ndk.2 uc009ndk.3 uc009ndk.1 uc009ndk.2 uc009ndk.3 
ENSMUST00000182869.2 Samd15 ENSMUST00000182869.2 sterile alpha motif domain containing 15 (from RefSeq NM_001290288.2) ENSMUST00000182869.1 F6XZJ7 Gm263 NM_001290288 SAM15_MOUSE uc056yrs.1 uc056yrs.2 uc056yrs.3 molecular_function uc056yrs.1 uc056yrs.2 uc056yrs.3 
ENSMUST00000182878.2 Gm26967 ENSMUST00000182878.2 Gm26967 (from geneSymbol) ENSMUST00000182878.1 uc291uxd.1 uc291uxd.2 uc291uxd.1 uc291uxd.2 
ENSMUST00000182884.8 Ank3 ENSMUST00000182884.8 ankyrin 3, epithelial, transcript variant 3 (from RefSeq NM_170688.2) ANK3_MOUSE ENSMUST00000182884.1 ENSMUST00000182884.2 ENSMUST00000182884.3 ENSMUST00000182884.4 ENSMUST00000182884.5 ENSMUST00000182884.6 ENSMUST00000182884.7 G5E8K4 G5E8K5 NM_170688 O08866 O08867 Q3TSJ8 Q4U205 Q4U206 Q4U256 Q4U260 Q61305 Q61306 Q61307 Q61308 Q61309 Q61310 Q8CBN3 Q8VC68 uc007fmx.1 uc007fmx.2 uc007fmx.3 This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for costamere localization of DMD and betaDAG1. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). May be a constituent of a NFASC/NRCAM/ankyrin G complex. Interacts with RHBG (By similarity). Directly interacts with DMD and betaDAG1; this interaction does not interfere with DMD-binding and is required for DMD and betaDAG1 retention at costameres. Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 7 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs). Interacts with PLEC and FLNC (By similarity). Interacts with KCNA1; this inhibits channel activity (PubMed:23903368). Interacts with SCN5A (By similarity). Cytoplasm, cytoskeleton Cell projection, axon Cell membrane, sarcolemma Postsynaptic cell membrane Lysosome Cell membrane, sarcolemma, T-tubule Note=In skeletal muscle, localized at costameres and neuromuscular junctions. In bone marrow-derived macrophages, isoforms 2 and 3 are associated with lysosomes. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=G5E8K5-1; Sequence=Displayed; Name=2; IsoId=G5E8K5-2; Sequence=VSP_044356, VSP_044358; Name=3; IsoId=G5E8K5-3; Sequence=VSP_044356; Name=4; IsoId=G5E8K5-4; Sequence=VSP_044355, VSP_044357; Name=5; IsoId=G5E8K5-5; Sequence=VSP_044355, VSP_044357, VSP_044359; Name=6; IsoId=G5E8K5-6; Sequence=VSP_044355, VSP_044357, VSP_044358; Expressed in many epithelial tissues, muscles and axons. Expressed in kidney, brain, skin, lung, liver, intestine, pancreas, heart and testis (at protein level). In testis, expressed in Leydig cells, but very weakly or not at all in Sertoli cells or seminiferous tubules. Expressed in macrophages (at protein level). In an in vitro model of myogenesis, not detected in proliferating myoblasts. Hardly detectable during the first days of differentiation. Expression greatly increases in mature myotubes. Up-regulated by high dietary Mg(2+) levels. Sequence=AAB58380.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAB58381.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; mitotic cytokinesis structural constituent of cytoskeleton protein binding cytoplasm lysosome cytoskeleton plasma membrane plasma membrane organization cytoskeleton organization signal transduction axonogenesis axon guidance neuromuscular junction development cytoskeletal protein binding basal plasma membrane cell surface positive regulation of gene expression positive regulation of cell communication by electrical coupling positive regulation of sodium ion transport magnesium ion homeostasis intercalated disc spectrin-associated cytoskeleton membrane basolateral plasma membrane lateral plasma membrane sarcoplasmic reticulum neuronal action potential Z disc cell junction T-tubule axon dendrite spectrin binding protein binding, bridging neuromuscular junction node of Ranvier paranode region of axon positive regulation of homotypic cell-cell adhesion sarcolemma cell projection Golgi to plasma membrane protein transport neuron projection axon initial segment regulation of potassium ion transport ion channel binding clustering of voltage-gated sodium channels establishment of protein localization synapse postsynaptic membrane cadherin binding positive regulation of action potential positive regulation of membrane potential synapse organization cellular response to magnesium ion membrane assembly protein localization to plasma membrane maintenance of protein location in plasma membrane positive regulation of protein targeting to membrane protein localization to axon positive regulation of membrane depolarization during cardiac muscle cell action potential negative regulation of delayed rectifier potassium channel activity positive regulation of sodium ion transmembrane transporter activity positive regulation of cation channel activity bicellular tight junction uc007fmx.1 uc007fmx.2 uc007fmx.3 
ENSMUST00000182891.2 Gm27048 ENSMUST00000182891.2 Gm27048 (from geneSymbol) AK158358 ENSMUST00000182891.1 uc292bhn.1 uc292bhn.2 uc292bhn.1 uc292bhn.2 
ENSMUST00000182894.2 Gm26968 ENSMUST00000182894.2 Gm26968 (from geneSymbol) ENSMUST00000182894.1 uc290nnn.1 uc290nnn.2 uc290nnn.1 uc290nnn.2 
ENSMUST00000182898.8 Anapc16 ENSMUST00000182898.8 anaphase promoting complex subunit 16, transcript variant 1 (from RefSeq NM_025514.4) APC16_MOUSE D10Ertd641e ENSMUST00000182898.1 ENSMUST00000182898.2 ENSMUST00000182898.3 ENSMUST00000182898.4 ENSMUST00000182898.5 ENSMUST00000182898.6 ENSMUST00000182898.7 NM_025514 Q9CPV2 uc007fef.1 uc007fef.2 uc007fef.3 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Protein modification; protein ubiquitination. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. ANAPC16 associates with the rest of the complex independently of ANAPC2 and ANAPC11. Cytoplasm Nucleus Chromosome, centromere, kinetochore Belongs to the APC16 family. chromosome, centromeric region kinetochore condensed chromosome kinetochore molecular_function nucleus anaphase-promoting complex chromosome cytoplasm cytosol cell cycle protein ubiquitination cell division uc007fef.1 uc007fef.2 uc007fef.3 
ENSMUST00000182899.2 Bdkrb1 ENSMUST00000182899.2 This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. (from UniProt Q61125) BKRB1_MOUSE Bdkrb ENSMUST00000182899.1 Q61125 Q9Z1F4 uc288iyt.1 uc288iyt.2 This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. Cell membrane ; Multi-pass membrane protein Expressed in heart, liver and lung. By lipopolysaccharide (LPS) in heart, liver and lung five hours after treatment. Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily. negative regulation of protein phosphorylation positive regulation of leukocyte migration G-protein coupled receptor activity bradykinin receptor activity plasma membrane inflammatory response signal transduction G-protein coupled receptor signaling pathway protein kinase C-activating G-protein coupled receptor signaling pathway response to mechanical stimulus membrane integral component of membrane cell migration sensory perception of pain negative regulation of cell growth response to lipopolysaccharide peptide binding neuron projection negative regulation of blood pressure positive regulation of release of sequestered calcium ion into cytosol uc288iyt.1 uc288iyt.2 
ENSMUST00000182901.2 ENSMUSG00000121415 ENSMUST00000182901.2 ENSMUSG00000121415 (from geneSymbol) ENSMUST00000182901.1 GU269230 uc291ohz.1 uc291ohz.2 uc291ohz.1 uc291ohz.2 
ENSMUST00000182943.2 Gm27000 ENSMUST00000182943.2 Gm27000 (from geneSymbol) ENSMUST00000182943.1 LF202103 uc292piq.1 uc292piq.2 uc292piq.1 uc292piq.2 
ENSMUST00000182952.3 1700120C18Rik ENSMUST00000182952.3 1700120C18Rik (from geneSymbol) AK007211 ENSMUST00000182952.1 ENSMUST00000182952.2 uc292bvt.1 uc292bvt.2 uc292bvt.3 uc292bvt.1 uc292bvt.2 uc292bvt.3 
ENSMUST00000182953.8 Miat ENSMUST00000182953.8 Miat (from geneSymbol) AB300594 ENSMUST00000182953.1 ENSMUST00000182953.2 ENSMUST00000182953.3 ENSMUST00000182953.4 ENSMUST00000182953.5 ENSMUST00000182953.6 ENSMUST00000182953.7 uc008ysl.1 uc008ysl.2 uc008ysl.3 uc008ysl.4 uc008ysl.1 uc008ysl.2 uc008ysl.3 uc008ysl.4 
ENSMUST00000182975.2 Scgb2b15 ENSMUST00000182975.2 secretoglobin, family 2B, member 6 (from RefSeq NM_001378690.1) ENSMUST00000182975.1 NM_001378690 S4R2V3 S4R2V3_MOUSE Scgb2b15 Scgb2b17 uc033iyq.1 uc033iyq.2 uc033iyq.3 Belongs to the secretoglobin family. molecular_function cellular_component extracellular space biological_process uc033iyq.1 uc033iyq.2 uc033iyq.3 
ENSMUST00000182989.3 ENSMUSG00000121670 ENSMUST00000182989.3 ENSMUSG00000121670 (from geneSymbol) ENSMUST00000182989.1 ENSMUST00000182989.2 uc291jey.1 uc291jey.2 uc291jey.1 uc291jey.2 
ENSMUST00000183032.8 Rbm6 ENSMUST00000183032.8 RNA binding motif protein 6, transcript variant 1 (from RefSeq NM_011251.3) ENSMUST00000183032.1 ENSMUST00000183032.2 ENSMUST00000183032.3 ENSMUST00000183032.4 ENSMUST00000183032.5 ENSMUST00000183032.6 ENSMUST00000183032.7 NM_011251 Rbm6 S4R1W5 S4R1W5_MOUSE uc012hal.1 uc012hal.2 uc012hal.3 uc012hal.4 nucleic acid binding RNA binding nucleus uc012hal.1 uc012hal.2 uc012hal.3 uc012hal.4 
ENSMUST00000183034.5 Dst ENSMUST00000183034.5 dystonin, transcript variant 1 (from RefSeq NM_001276764.1) Dst ENSMUST00000183034.1 ENSMUST00000183034.2 ENSMUST00000183034.3 ENSMUST00000183034.4 NM_001276764 S4R1P5 S4R1P5_MOUSE uc007aon.1 uc007aon.2 uc007aon.3 uc007aon.4 Cytoplasm, cytoskeleton Belongs to the plakin or cytolinker family. actin binding calcium ion binding cytoskeleton cytoskeleton organization microtubule binding cytoskeletal protein binding uc007aon.1 uc007aon.2 uc007aon.3 uc007aon.4 
ENSMUST00000183056.2 Gm27019 ENSMUST00000183056.2 Gm27019 (from geneSymbol) DM176682 ENSMUST00000183056.1 uc291dgp.1 uc291dgp.2 uc291dgp.1 uc291dgp.2 
ENSMUST00000183083.10 Bvht ENSMUST00000183083.10 Bvht (from geneSymbol) AK143260 ENSMUST00000183083.1 ENSMUST00000183083.2 ENSMUST00000183083.3 ENSMUST00000183083.4 ENSMUST00000183083.5 ENSMUST00000183083.6 ENSMUST00000183083.7 ENSMUST00000183083.8 ENSMUST00000183083.9 uc289phg.1 uc289phg.2 uc289phg.3 uc289phg.4 uc289phg.1 uc289phg.2 uc289phg.3 uc289phg.4 
ENSMUST00000183096.8 Sipa1l3 ENSMUST00000183096.8 Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). (from UniProt G3X9J0) AK172968 ENSMUST00000183096.1 ENSMUST00000183096.2 ENSMUST00000183096.3 ENSMUST00000183096.4 ENSMUST00000183096.5 ENSMUST00000183096.6 ENSMUST00000183096.7 G3X9J0 SI1L3_MOUSE Spal3 uc057ltr.1 uc057ltr.2 uc057ltr.3 Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). Apical cell membrane Note=Detected in tricellular junctions. Colocalizes with apical F-actin. Expressed in the developing lens. Deficient mice at 4 weeks postnatal age show reduced lens size and microphthalmia (PubMed:26231217). eye development stress fiber hematopoietic progenitor cell differentiation epithelial cell morphogenesis molecular_function GTPase activator activity plasma membrane cytoskeleton organization membrane apical plasma membrane positive regulation of GTPase activity apical part of cell regulation of small GTPase mediated signal transduction tricellular tight junction establishment of epithelial cell polarity uc057ltr.1 uc057ltr.2 uc057ltr.3 
ENSMUST00000183104.8 Osbpl10 ENSMUST00000183104.8 oxysterol binding protein-like 10 (from RefSeq NM_148958.3) ENSMUST00000183104.1 ENSMUST00000183104.2 ENSMUST00000183104.3 ENSMUST00000183104.4 ENSMUST00000183104.5 ENSMUST00000183104.6 ENSMUST00000183104.7 NM_148958 OSB10_MOUSE Orp10 Osbpl10 Q8R2T7 S4R1M9 uc292lyo.1 uc292lyo.2 Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P. Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine. Interacts with OSBPL9. Interacts with DIAPH1. Cytoplasm, cytoskeleton Note=Associates with microtubules. The C-terminal region binds cholesterol, 25-hydroxysterol and acidic phospholipids and is required for localization to microtubules. The PH domain selectively interacts with phosphatidylinositol- 4-phosphate. phosphatidylserine binding cytoplasm cytosol cytoskeleton lipid metabolic process lipid transport biological_process lipid binding cholesterol binding membrane sterol binding intracellular membrane-bounded organelle uc292lyo.1 uc292lyo.2 
ENSMUST00000183110.2 Gm27027 ENSMUST00000183110.2 Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; (from UniProt S4R1M6) AK007557 ENSMUST00000183110.1 Gm27027 S4R1M6 S4R1M6_MOUSE uc289yqq.1 uc289yqq.2 Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; nucleus DNA repair DNA dealkylation involved in DNA repair oxidoreductase activity oxidative single-stranded DNA demethylation dioxygenase activity oxidation-reduction process uc289yqq.1 uc289yqq.2 
ENSMUST00000183125.2 Zfp386 ENSMUST00000183125.2 zinc finger protein 386 (Kruppel-like), transcript variant 1 (from RefSeq NM_001004066.3) ENSMUST00000183125.1 NM_001004066 Q1WWJ5 Q1WWJ5_MOUSE Zfp386 uc007phb.1 uc007phb.2 uc007phb.3 uc007phb.4 uc007phb.5 nucleic acid binding DNA binding chromatin binding cellular_component regulation of transcription, DNA-templated metal ion binding negative regulation of transcription involved in meiotic cell cycle uc007phb.1 uc007phb.2 uc007phb.3 uc007phb.4 uc007phb.5 
ENSMUST00000183126.2 Arl14 ENSMUST00000183126.2 ADP-ribosylation factor-like 14 (from RefSeq NM_027843.1) Arl14 ENSMUST00000183126.1 NM_027843 S4R1T9 S4R1T9_MOUSE uc012cqm.1 uc012cqm.2 Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTP binding uc012cqm.1 uc012cqm.2 
ENSMUST00000183130.3 Ccdc166 ENSMUST00000183130.3 coiled-coil domain containing 166, transcript variant 1 (from RefSeq NM_146059.2) Ccdc166 ENSMUST00000183130.1 ENSMUST00000183130.2 NM_146059 S4R181 S4R181_MOUSE uc011zuo.1 uc011zuo.2 uc011zuo.3 molecular_function cellular_component biological_process uc011zuo.1 uc011zuo.2 uc011zuo.3 
ENSMUST00000183144.8 Mirg ENSMUST00000183144.8 Mirg (from geneSymbol) ENSMUST00000183144.1 ENSMUST00000183144.2 ENSMUST00000183144.3 ENSMUST00000183144.4 ENSMUST00000183144.5 ENSMUST00000183144.6 ENSMUST00000183144.7 EU616813 uc288jfg.1 uc288jfg.2 uc288jfg.1 uc288jfg.2 
ENSMUST00000183146.2 Rnf113a2 ENSMUST00000183146.2 ring finger protein 113A2 (from RefSeq NM_025525.2) ENSMUST00000183146.1 NM_025525 Q14B01 Q14B01_MOUSE Rnf113a2 uc007ofj.1 uc007ofj.2 uc007ofj.3 mRNA splicing, via spliceosome ubiquitin-protein transferase activity nucleus U2-type spliceosomal complex protein ubiquitination isopeptide cross-linking via N6-glycyl-L-lysine snoRNA splicing metal ion binding negative regulation of chemokine-mediated signaling pathway U2-type precatalytic spliceosome uc007ofj.1 uc007ofj.2 uc007ofj.3 
ENSMUST00000183156.8 Anks1b ENSMUST00000183156.8 ankyrin repeat and sterile alpha motif domain containing 1B, transcript variant 9 (from RefSeq NM_001359241.1) Anks1b ENSMUST00000183156.1 ENSMUST00000183156.2 ENSMUST00000183156.3 ENSMUST00000183156.4 ENSMUST00000183156.5 ENSMUST00000183156.6 ENSMUST00000183156.7 NM_001359241 S4R286 S4R286_MOUSE uc287tzo.1 uc287tzo.2 Cytoplasm regulation of synaptic plasticity by receptor localization to synapse uc287tzo.1 uc287tzo.2 
ENSMUST00000183157.3 Gm50115 ENSMUST00000183157.3 Gm50115 (from geneSymbol) ENSMUST00000183157.1 ENSMUST00000183157.2 uc289pkb.1 uc289pkb.2 uc289pkb.3 uc289pkb.1 uc289pkb.2 uc289pkb.3 
ENSMUST00000183171.2 A830082K12Rik ENSMUST00000183171.2 A830082K12Rik (from geneSymbol) AK051417 ENSMUST00000183171.1 uc007rhg.1 uc007rhg.2 uc007rhg.1 uc007rhg.2 
ENSMUST00000183185.2 ENSMUSG00000121772 ENSMUST00000183185.2 ENSMUSG00000121772 (from geneSymbol) BC132661 ENSMUST00000183185.1 uc290wpv.1 uc290wpv.2 uc290wpv.1 uc290wpv.2 
ENSMUST00000183187.2 Tktl2 ENSMUST00000183187.2 transketolase-like 2, transcript variant 2 (from RefSeq NM_001271574.1) A0A0R4J2A3 A0A0R4J2A3_MOUSE ENSMUST00000183187.1 NM_001271574 Tktl2 uc009lvq.1 uc009lvq.2 uc009lvq.3 uc009lvq.4 Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Homodimer. catalytic activity cytoplasm uc009lvq.1 uc009lvq.2 uc009lvq.3 uc009lvq.4 
ENSMUST00000183195.2 Scgb2b12 ENSMUST00000183195.2 secretoglobin, family 2B, member 12 (from RefSeq NM_001281508.1) Abpbg12 ENSMUST00000183195.1 NM_001281508 S4R2L0 S4R2L0_MOUSE Scgb2b12 uc033iyp.1 uc033iyp.2 Secreted Belongs to the secretoglobin family. molecular_function cellular_component extracellular space biological_process uc033iyp.1 uc033iyp.2 
ENSMUST00000183200.8 Cacng6 ENSMUST00000183200.8 calcium channel, voltage-dependent, gamma subunit 6 (from RefSeq NM_133183.2) CCG6_MOUSE ENSMUST00000183200.1 ENSMUST00000183200.2 ENSMUST00000183200.3 ENSMUST00000183200.4 ENSMUST00000183200.5 ENSMUST00000183200.6 ENSMUST00000183200.7 NM_133183 Q8VHW3 uc009euy.1 uc009euy.2 uc009euy.3 uc009euy.4 Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Interacts with CACNA1C (PubMed:21127204). Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or CACNB2 (By similarity). Cell membrane ; Multi-pass membrane protein Detected in brain and heart (at protein level). Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. voltage-gated ion channel activity calcium channel regulator activity calcium channel activity plasma membrane ion transport calcium ion transport membrane integral component of membrane regulation of ion transmembrane transport calcium ion transmembrane transport L-type voltage-gated calcium channel complex uc009euy.1 uc009euy.2 uc009euy.3 uc009euy.4 
ENSMUST00000183203.2 Gm26969 ENSMUST00000183203.2 Gm26969 (from geneSymbol) ENSMUST00000183203.1 uc288vbk.1 uc288vbk.2 uc288vbk.1 uc288vbk.2 
ENSMUST00000183217.9 Piezo2 ENSMUST00000183217.9 Membrane ulti-pass membrane protein (from UniProt S4R2S0) ENSMUST00000183217.1 ENSMUST00000183217.2 ENSMUST00000183217.3 ENSMUST00000183217.4 ENSMUST00000183217.5 ENSMUST00000183217.6 ENSMUST00000183217.7 ENSMUST00000183217.8 MG254546 Piezo2 S4R2S0 S4R2S0_MOUSE uc289pii.1 uc289pii.2 uc289pii.3 Membrane ulti-pass membrane protein Belongs to the PIEZO (TC 1.A.75) family. Lacks conserved residue(s) required for the propagation of feature annotation. mechanically-gated ion channel activity membrane integral component of membrane transmembrane transport uc289pii.1 uc289pii.2 uc289pii.3 
ENSMUST00000183219.8 Hmx2 ENSMUST00000183219.8 H6 homeobox 2, transcript variant 2 (from RefSeq NM_001368360.1) ENSMUST00000183219.1 ENSMUST00000183219.2 ENSMUST00000183219.3 ENSMUST00000183219.4 ENSMUST00000183219.5 ENSMUST00000183219.6 ENSMUST00000183219.7 HMX2_MOUSE NM_001368360 Nkx-5.2 Nkx5-2 P43687 Q3UUN6 Q8R1Q2 uc057lvl.1 uc057lvl.2 uc057lvl.3 Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Nucleus Expressed in the developing CNS, including a specific expression in vestibular structures throughout inner ear development. It is expressed in neuronal and neuroepithelial cells during development of the CNS and PNS. Mice display a perturbation in cell fate determination in the lateral aspect of the otic epithelium results in reduced cell proliferation in epithelial cells, which includes the vestibular sensory patches and semicircular duct fusion plates, as well as in the adjacent mesenchyme. Consequently, enlargement and morphogenesis of the pars superior of the otocyst to form a complex labyrinth of cavities and ducts is blocked, as indicated by the lack of any distinguishable semicircular ducts, persistence of the primordial vestibular diverticula, significant loss in the 3 cristae and the macula utriculus, and a fused utriculosaccular chamber. Mice lacking both Hmx2 and Hmx3 show a complete loss of balance, postnatal dwarfism, defects in neuroendocrine system, disturbed hypothalamic-pituitary axis and subsequent die. Defects caused in mice lacking both Hmx2 and Hmx3 can be rescued by expressing the Drosophila Hmx protein. Belongs to the HMX homeobox family. DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development nervous system development brain development positive regulation of cell proliferation cell differentiation inner ear morphogenesis sequence-specific DNA binding positive regulation of mRNA splicing, via spliceosome uc057lvl.1 uc057lvl.2 uc057lvl.3 
ENSMUST00000183220.2 Gm24362 ENSMUST00000183220.2 Gm24362 (from geneSymbol) ENSMUST00000183220.1 LF204827 uc290qxr.1 uc290qxr.2 uc290qxr.1 uc290qxr.2 
ENSMUST00000183225.2 Gm27022 ENSMUST00000183225.2 Gm27022 (from geneSymbol) ENSMUST00000183225.1 uc290qys.1 uc290qys.2 uc290qys.1 uc290qys.2 
ENSMUST00000183226.2 Gm27033 ENSMUST00000183226.2 Gm27033 (from geneSymbol) ENSMUST00000183226.1 uc291bvj.1 uc291bvj.2 uc291bvj.1 uc291bvj.2 
ENSMUST00000183231.9 Gm26973 ENSMUST00000183231.9 Gm26973 (from geneSymbol) ENSMUST00000183231.1 ENSMUST00000183231.2 ENSMUST00000183231.3 ENSMUST00000183231.4 ENSMUST00000183231.5 ENSMUST00000183231.6 ENSMUST00000183231.7 ENSMUST00000183231.8 uc288gmq.1 uc288gmq.2 uc288gmq.3 uc288gmq.1 uc288gmq.2 uc288gmq.3 
ENSMUST00000183235.2 A330074K22Rik ENSMUST00000183235.2 RIKEN cDNA A330074K22 gene (from RefSeq NR_110496.1) ENSMUST00000183235.1 NR_110496 uc009nqy.1 uc009nqy.2 uc009nqy.1 uc009nqy.2 
ENSMUST00000183254.3 Or52z1 ENSMUST00000183254.3 olfactory receptor family 52 subfamily Z member 1 (from RefSeq NM_013619.3) ENSMUST00000183254.1 ENSMUST00000183254.2 F8VPJ8 F8VPJ8_MOUSE NM_013619 Olfr67 Or52z1 uc009iuo.1 uc009iuo.2 uc009iuo.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009iuo.1 uc009iuo.2 uc009iuo.3 
ENSMUST00000183285.2 ENSMUSG00000121802 ENSMUST00000183285.2 ENSMUSG00000121802 (from geneSymbol) ENSMUST00000183285.1 uc288uwu.1 uc288uwu.2 uc288uwu.1 uc288uwu.2 
ENSMUST00000183291.2 Oas1b ENSMUST00000183291.2 2'-5' oligoadenylate synthetase 1B, transcript variant 1, non-coding (from RefSeq NR_003507.1) ENSMUST00000183291.1 NR_003507 uc290zdq.1 uc290zdq.2 This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008]. uc290zdq.1 uc290zdq.2 
ENSMUST00000183294.3 Gm27016 ENSMUST00000183294.3 Gm27016 (from geneSymbol) ENSMUST00000183294.1 ENSMUST00000183294.2 uc292bvs.1 uc292bvs.2 uc292bvs.3 uc292bvs.1 uc292bvs.2 uc292bvs.3 
ENSMUST00000183300.2 Gm27004 ENSMUST00000183300.2 Gm27004 (from geneSymbol) ENSMUST00000183300.1 uc290ykb.1 uc290ykb.2 uc290ykb.1 uc290ykb.2 
ENSMUST00000183304.2 Gm26916 ENSMUST00000183304.2 Gm26916 (from geneSymbol) ENSMUST00000183304.1 uc288vaw.1 uc288vaw.2 uc288vaw.1 uc288vaw.2 
ENSMUST00000183309.8 Rpf2 ENSMUST00000183309.8 ribosome production factor 2 homolog, transcript variant 1 (from RefSeq NM_023323.3) Bxdc1 ENSMUST00000183309.1 ENSMUST00000183309.2 ENSMUST00000183309.3 ENSMUST00000183309.4 ENSMUST00000183309.5 ENSMUST00000183309.6 ENSMUST00000183309.7 MNCb-4285 NM_023323 Q8R3K6 Q9CQ34 Q9CSY9 Q9CYR9 Q9JJ80 RPF2_MOUSE uc007ewp.1 uc007ewp.2 uc007ewp.3 Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. Nucleus, nucleolus Note=Associated with the nucleolus in an RNA-dependent manner. Belongs to the RPF2 family. ribosomal large subunit assembly maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of LSU-rRNA RNA polymerase II transcription factor activity, sequence-specific DNA binding nucleus nucleolus regulation of transcription from RNA polymerase II promoter 5S rRNA binding rRNA binding ribosome biogenesis ribosomal large subunit biogenesis regulation of signal transduction by p53 class mediator protein localization to nucleolus uc007ewp.1 uc007ewp.2 uc007ewp.3 
ENSMUST00000183310.2 Btbd19 ENSMUST00000183310.2 BTB domain containing 19 (from RefSeq NM_001384196.1) Btbd19 ENSMUST00000183310.1 NM_001384196 S4R1I0 S4R1I0_MOUSE uc290pbz.1 uc290pbz.2 molecular_function cellular_component biological_process uc290pbz.1 uc290pbz.2 
ENSMUST00000183317.8 Ptprv ENSMUST00000183317.8 protein tyrosine phosphatase receptor type V, transcript variant 1, non-coding (from RefSeq NR_153383.1) ENSMUST00000183317.1 ENSMUST00000183317.2 ENSMUST00000183317.3 ENSMUST00000183317.4 ENSMUST00000183317.5 ENSMUST00000183317.6 ENSMUST00000183317.7 NR_153383 uc287lyd.1 uc287lyd.2 uc287lyd.1 uc287lyd.2 
ENSMUST00000183323.4 Gm29361 ENSMUST00000183323.4 Gm29361 (from geneSymbol) ENSMUST00000183323.1 ENSMUST00000183323.2 ENSMUST00000183323.3 LF199233 uc288hrr.1 uc288hrr.2 uc288hrr.3 uc288hrr.1 uc288hrr.2 uc288hrr.3 
ENSMUST00000183337.2 Gm5177 ENSMUST00000183337.2 predicted pseudogene 5177 (from RefSeq NR_033630.1) ENSMUST00000183337.1 NR_033630 uc011xac.1 uc011xac.2 uc011xac.1 uc011xac.2 
ENSMUST00000183339.8 Gm27177 ENSMUST00000183339.8 Gm27177 (from geneSymbol) ENSMUST00000183339.1 ENSMUST00000183339.2 ENSMUST00000183339.3 ENSMUST00000183339.4 ENSMUST00000183339.5 ENSMUST00000183339.6 ENSMUST00000183339.7 uc288vki.1 uc288vki.2 uc288vki.1 uc288vki.2 
ENSMUST00000183342.3 Mir6992 ENSMUST00000183342.3 microRNA 6992 (from RefSeq NR_105958.1) ENSMUST00000183342.1 ENSMUST00000183342.2 NR_105958 uc033hiy.1 uc033hiy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hiy.1 uc033hiy.2 
ENSMUST00000183343.3 Mir6998 ENSMUST00000183343.3 microRNA 6998 (from RefSeq NR_105964.1) ENSMUST00000183343.1 ENSMUST00000183343.2 NR_105964 uc033hmj.1 uc033hmj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hmj.1 uc033hmj.2 
ENSMUST00000183344.2 Gm27169 ENSMUST00000183344.2 Gm27169 (from geneSymbol) ENSMUST00000183344.1 uc292bvc.1 uc292bvc.2 uc292bvc.1 uc292bvc.2 
ENSMUST00000183345.2 Triqk ENSMUST00000183345.2 May play a role in cell growth and maintenance of cell morphology. (from UniProt B2B9E1) B2B9E1 DQ351292 ENSMUST00000183345.1 Gm11818 TRIQK_MOUSE uc008sas.1 uc008sas.2 uc008sas.3 uc008sas.4 May play a role in cell growth and maintenance of cell morphology. Endoplasmic reticulum membrane ; Single-pass membrane protein Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Expressed in embryo from 7 to 17 dpc. Belongs to the TRIQK family. endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane uc008sas.1 uc008sas.2 uc008sas.3 uc008sas.4 
ENSMUST00000183346.3 Mir7045 ENSMUST00000183346.3 microRNA 7045 (from RefSeq NR_106012.1) ENSMUST00000183346.1 ENSMUST00000183346.2 NR_106012 uc033ius.1 uc033ius.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ius.1 uc033ius.2 
ENSMUST00000183357.3 Mir6378 ENSMUST00000183357.3 microRNA 6378 (from RefSeq NR_105799.1) ENSMUST00000183357.1 ENSMUST00000183357.2 NR_105799 uc033hsy.1 uc033hsy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hsy.1 uc033hsy.2 
ENSMUST00000183361.3 Mir8094 ENSMUST00000183361.3 microRNA 8094 (from RefSeq NR_106169.1) ENSMUST00000183361.1 ENSMUST00000183361.2 NR_106169 uc033hdj.1 uc033hdj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hdj.1 uc033hdj.2 
ENSMUST00000183364.3 Mir7647 ENSMUST00000183364.3 microRNA 7647 (from RefSeq NR_106105.1) ENSMUST00000183364.1 ENSMUST00000183364.2 NR_106105 uc033ilx.1 uc033ilx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ilx.1 uc033ilx.2 
ENSMUST00000183370.3 Mir6955 ENSMUST00000183370.3 microRNA 6955 (from RefSeq NR_105920.1) ENSMUST00000183370.1 ENSMUST00000183370.2 NR_105920 uc033gvd.1 uc033gvd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gvd.1 uc033gvd.2 
ENSMUST00000183371.3 Mir8119 ENSMUST00000183371.3 microRNA 8119 (from RefSeq NR_106199.1) ENSMUST00000183371.1 ENSMUST00000183371.2 NR_106199 uc033iev.1 uc033iev.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iev.1 uc033iev.2 
ENSMUST00000183376.3 Mir7655 ENSMUST00000183376.3 microRNA 7655 (from RefSeq NR_106115.1) ENSMUST00000183376.1 ENSMUST00000183376.2 NR_106115 uc033hln.1 uc033hln.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hln.1 uc033hln.2 
ENSMUST00000183378.4 V1rg10 ENSMUST00000183378.4 Cell membrane ; Multi-pass membrane protein (from UniProt A0A5F8MPF7) A0A5F8MPF7 A0A5F8MPF7_MOUSE ENSMUST00000183378.1 ENSMUST00000183378.2 ENSMUST00000183378.3 V1rg10 uc290srr.1 uc290srr.2 uc290srr.3 Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. uc290srr.1 uc290srr.2 uc290srr.3 
ENSMUST00000183384.3 Mir7239 ENSMUST00000183384.3 microRNA 7239 (from RefSeq NR_106098.1) ENSMUST00000183384.1 ENSMUST00000183384.2 NR_106098 uc033ful.1 uc033ful.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ful.1 uc033ful.2 
ENSMUST00000183385.3 Mir6367 ENSMUST00000183385.3 microRNA 6367 (from RefSeq NR_105786.1) ENSMUST00000183385.1 ENSMUST00000183385.2 NR_105786 uc056zda.1 uc056zda.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zda.1 uc056zda.2 
ENSMUST00000183387.8 4930524O08Rik ENSMUST00000183387.8 RIKEN cDNA 4930524O08 gene (from RefSeq NR_040735.1) ENSMUST00000183387.1 ENSMUST00000183387.2 ENSMUST00000183387.3 ENSMUST00000183387.4 ENSMUST00000183387.5 ENSMUST00000183387.6 ENSMUST00000183387.7 NR_040735 uc009qzq.1 uc009qzq.2 uc009qzq.1 uc009qzq.2 
ENSMUST00000183389.3 Mir6338 ENSMUST00000183389.3 microRNA 6338 (from RefSeq NR_105756.1) ENSMUST00000183389.1 ENSMUST00000183389.2 NR_105756 uc033fxu.1 uc033fxu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fxu.1 uc033fxu.2 
ENSMUST00000183392.3 Mir6379 ENSMUST00000183392.3 microRNA 6379 (from RefSeq NR_105800.1) ENSMUST00000183392.1 ENSMUST00000183392.2 NR_105800 uc056zsa.1 uc056zsa.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zsa.1 uc056zsa.2 
ENSMUST00000183396.3 Mir6364 ENSMUST00000183396.3 microRNA 6364 (from RefSeq NR_105783.1) ENSMUST00000183396.1 ENSMUST00000183396.2 NR_105783 uc056zax.1 uc056zax.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zax.1 uc056zax.2 
ENSMUST00000183398.2 Gm27222 ENSMUST00000183398.2 Gm27222 (from geneSymbol) ENSMUST00000183398.1 uc288vjf.1 uc288vjf.2 uc288vjf.1 uc288vjf.2 
ENSMUST00000183404.8 Tcf12 ENSMUST00000183404.8 transcription factor 12, transcript variant 1 (from RefSeq NM_011544.3) Alf1 E9QPN4 ENSMUST00000183404.1 ENSMUST00000183404.2 ENSMUST00000183404.3 ENSMUST00000183404.4 ENSMUST00000183404.5 ENSMUST00000183404.6 ENSMUST00000183404.7 HTF4_MOUSE Meb NM_011544 Q61286 uc009qpf.1 uc009qpf.2 uc009qpf.3 uc009qpf.4 Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (PubMed:18214987). May be involved in the functional network that regulates the development of the GnRH axis (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin, E12 and ITF2 proteins and RUNX1T1 (By similarity). Interacts with PTF1A. Interacts with NEUROD2. Interacts with BHLHA9. Q61286; P22091: Tal1; NbExp=2; IntAct=EBI-8006499, EBI-8006437; Nucleus. Event=Alternative splicing; Named isoforms=2; Name=ALF1B; Synonyms=ME1A; IsoId=Q61286-1; Sequence=Displayed; Name=ALF1A; Synonyms=ME1B; IsoId=Q61286-2; Sequence=VSP_002105; Widely expressed. Abundantly expressed during development of the central nervous system, in particular in proliferating neuroblasts and in cells at the initial stages of differentiation. Also expressed at high levels in morphogenetically active regions such as limb buds, somites and mesonephric tubules. Expression decreases once cellular differentiation is over. Mice are smaller than their wild-type littermates and fail to thrive 14 days after birth. nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex cytoplasm multicellular organism development nervous system development transcription factor binding positive regulation of gene expression nuclear speck cell differentiation cAMP response element binding protein homodimerization activity intracellular membrane-bounded organelle bHLH transcription factor binding transcription regulatory region DNA binding positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter SMAD binding protein heterodimerization activity protein dimerization activity E-box binding HMG box domain binding RNA polymerase II transcription factor complex uc009qpf.1 uc009qpf.2 uc009qpf.3 uc009qpf.4 
ENSMUST00000183406.3 Mir6402 ENSMUST00000183406.3 microRNA 6402 (from RefSeq NR_105828.1) ENSMUST00000183406.1 ENSMUST00000183406.2 NR_105828 uc033idf.1 uc033idf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033idf.1 uc033idf.2 
ENSMUST00000183408.3 Mir7027 ENSMUST00000183408.3 microRNA 7027 (from RefSeq NR_105994.1) ENSMUST00000183408.1 ENSMUST00000183408.2 NR_105994 uc033ili.1 uc033ili.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ili.1 uc033ili.2 
ENSMUST00000183409.2 Gvin1 ENSMUST00000183409.2 GTPase, very large interferon inducible 1, transcript variant 1 (from RefSeq NM_029000.3) ENSMUST00000183409.1 Gvin1 L7N451 L7N451_MOUSE NM_029000 uc009izp.1 uc009izp.2 uc009izp.3 uc009izp.4 Nucleus Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family. GTP binding uc009izp.1 uc009izp.2 uc009izp.3 uc009izp.4 
ENSMUST00000183412.3 Mir6954 ENSMUST00000183412.3 microRNA 6954 (from RefSeq NR_105919.1) ENSMUST00000183412.1 ENSMUST00000183412.2 NR_105919 uc033gur.1 uc033gur.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gur.1 uc033gur.2 
ENSMUST00000183413.3 Gm27227 ENSMUST00000183413.3 predicted gene 27227 (from RefSeq NR_166662.1) ENSMUST00000183413.1 ENSMUST00000183413.2 NR_166662 uc292jdk.1 uc292jdk.2 uc292jdk.3 uc292jdk.1 uc292jdk.2 uc292jdk.3 
ENSMUST00000183426.3 Mir6381 ENSMUST00000183426.3 microRNA 6381 (from RefSeq NR_105802.1) ENSMUST00000183426.1 ENSMUST00000183426.2 NR_105802 uc033iae.1 uc033iae.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iae.1 uc033iae.2 
ENSMUST00000183433.3 Mir7223 ENSMUST00000183433.3 microRNA 7223 (from RefSeq NR_106082.1) ENSMUST00000183433.1 ENSMUST00000183433.2 NR_106082 uc029rph.1 uc029rph.2 uc029rph.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029rph.1 uc029rph.2 uc029rph.3 
ENSMUST00000183435.3 Mir7046 ENSMUST00000183435.3 microRNA 7046 (from RefSeq NR_106013.1) ENSMUST00000183435.1 ENSMUST00000183435.2 NR_106013 uc033ixn.1 uc033ixn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ixn.1 uc033ixn.2 
ENSMUST00000183437.8 Fam83b ENSMUST00000183437.8 family with sequence similarity 83, member B (from RefSeq NM_001045518.2) ENSMUST00000183437.1 ENSMUST00000183437.2 ENSMUST00000183437.3 ENSMUST00000183437.4 ENSMUST00000183437.5 ENSMUST00000183437.6 ENSMUST00000183437.7 FA83B_MOUSE Fam83b NM_001045518 Q0VBM2 Q8BWY1 uc009qtc.1 uc009qtc.2 uc009qtc.3 Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. Interacts with EGFR; positively regulates EGFR inducing its autophosphorylation in absence of stimulation by EGF. Interacts with RAF1; displaces 14-3-3 proteins from RAF1 and activates RAF1 within the RAS/MAPK signaling cascade. Interacts with AKT1, PIK3CA and PIK3R1; activates the PI3K/AKT signaling cascade. Cytoplasm Membrane Belongs to the FAM83 family. epidermal growth factor receptor binding cytoplasm epidermal growth factor receptor signaling pathway cell proliferation membrane protein kinase binding phosphatidylinositol 3-kinase regulatory subunit binding phosphatidylinositol 3-kinase catalytic subunit binding uc009qtc.1 uc009qtc.2 uc009qtc.3 
ENSMUST00000183439.3 Mir7068 ENSMUST00000183439.3 microRNA 7068 (from RefSeq NR_106036.1) ENSMUST00000183439.1 ENSMUST00000183439.2 NR_106036 uc033jgf.1 uc033jgf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jgf.1 uc033jgf.2 
ENSMUST00000183442.3 Mir7669 ENSMUST00000183442.3 microRNA 7669 (from RefSeq NR_106129.1) ENSMUST00000183442.1 ENSMUST00000183442.2 NR_106129 uc056ztm.1 uc056ztm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056ztm.1 uc056ztm.2 
ENSMUST00000183443.3 Mir6904 ENSMUST00000183443.3 microRNA 6904 (from RefSeq NR_105869.1) ENSMUST00000183443.1 ENSMUST00000183443.2 NR_105869 uc033foh.1 uc033foh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033foh.1 uc033foh.2 
ENSMUST00000183447.3 Mir6940 ENSMUST00000183447.3 microRNA 6940 (from RefSeq NR_105905.1) ENSMUST00000183447.1 ENSMUST00000183447.2 NR_105905 uc033gfu.1 uc033gfu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gfu.1 uc033gfu.2 
ENSMUST00000183449.3 Mir6960 ENSMUST00000183449.3 microRNA 6960 (from RefSeq NR_105925.1) ENSMUST00000183449.1 ENSMUST00000183449.2 NR_105925 uc033gwn.1 uc033gwn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gwn.1 uc033gwn.2 
ENSMUST00000183455.3 Mir7578 ENSMUST00000183455.3 microRNA 7578 (from RefSeq NR_106102.1) ENSMUST00000183455.1 ENSMUST00000183455.2 NR_106102 uc033hmd.1 uc033hmd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hmd.1 uc033hmd.2 
ENSMUST00000183458.3 Mir6983 ENSMUST00000183458.3 microRNA 6983 (from RefSeq NR_105949.1) ENSMUST00000183458.1 ENSMUST00000183458.2 NR_105949 uc033hhm.1 uc033hhm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hhm.1 uc033hhm.2 
ENSMUST00000183462.3 Mir6344 ENSMUST00000183462.3 microRNA 6344 (from RefSeq NR_105762.1) ENSMUST00000183462.1 ENSMUST00000183462.2 NR_105762 uc033fjw.1 uc033fjw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fjw.1 uc033fjw.2 
ENSMUST00000183464.3 Mir7010 ENSMUST00000183464.3 microRNA 7010 (from RefSeq NR_105977.1) ENSMUST00000183464.1 ENSMUST00000183464.2 NR_105977 uc033huj.1 uc033huj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033huj.1 uc033huj.2 
ENSMUST00000183479.3 Mir6918 ENSMUST00000183479.3 microRNA 6918 (from RefSeq NR_105883.1) ENSMUST00000183479.1 ENSMUST00000183479.2 NR_105883 uc033ftr.1 uc033ftr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ftr.1 uc033ftr.2 
ENSMUST00000183482.2 Htr1b ENSMUST00000183482.2 5-hydroxytryptamine (serotonin) receptor 1B, transcript variant 1 (from RefSeq NM_010482.2) ENSMUST00000183482.1 Htr1b NM_010482 Q0VES5 Q0VES5_MOUSE uc009qvl.1 uc009qvl.2 uc009qvl.3 G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. Homodimer. Heterodimer with HTR1D. Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Ligands are bound in a hydrophobic pocket formed by the transmembrane helices. Palmitoylated. Phosphorylated. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting serotonin receptor signaling pathway chemical synaptic transmission feeding behavior drug binding regulation of dopamine secretion membrane integral component of membrane negative regulation of synaptic transmission, GABAergic cellular response to drug response to cocaine vasoconstriction drinking behavior calyx of Held response to ethanol bone remodeling regulation of behavior serotonin binding response to mineralocorticoid negative regulation of synaptic transmission, glutamatergic cellular response to alkaloid regulation of presynaptic cytosolic calcium ion concentration voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels positive regulation of vascular smooth muscle cell proliferation regulation of synaptic vesicle exocytosis uc009qvl.1 uc009qvl.2 uc009qvl.3 
ENSMUST00000183483.3 Mir6900 ENSMUST00000183483.3 microRNA 6900 (from RefSeq NR_105865.1) ENSMUST00000183483.1 ENSMUST00000183483.2 NR_105865 uc033fko.1 uc033fko.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fko.1 uc033fko.2 
ENSMUST00000183485.2 Gm27221 ENSMUST00000183485.2 Gm27221 (from geneSymbol) AK020757 ENSMUST00000183485.1 uc288vjr.1 uc288vjr.2 uc288vjr.1 uc288vjr.2 
ENSMUST00000183486.3 Mir7060 ENSMUST00000183486.3 microRNA 7060 (from RefSeq NR_106027.1) ENSMUST00000183486.1 ENSMUST00000183486.2 NR_106027 uc033jcg.1 uc033jcg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jcg.1 uc033jcg.2 
ENSMUST00000183490.3 Mir6341 ENSMUST00000183490.3 microRNA 6341 (from RefSeq NR_105759.1) ENSMUST00000183490.1 ENSMUST00000183490.2 NR_105759 uc033fic.1 uc033fic.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fic.1 uc033fic.2 
ENSMUST00000183491.3 Mir7676-1 ENSMUST00000183491.3 microRNA 7676-1 (from RefSeq NR_106137.1) ENSMUST00000183491.1 ENSMUST00000183491.2 NR_106137 uc033gux.1 uc033gux.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gux.1 uc033gux.2 
ENSMUST00000183494.3 Mir3473g ENSMUST00000183494.3 microRNA 3473g (from RefSeq NR_106202.1) ENSMUST00000183494.1 ENSMUST00000183494.2 NR_106202 uc033hpx.1 uc033hpx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hpx.1 uc033hpx.2 
ENSMUST00000183497.3 Mir6971 ENSMUST00000183497.3 microRNA 6971 (from RefSeq NR_105937.1) ENSMUST00000183497.1 ENSMUST00000183497.2 NR_105937 uc033hcx.1 uc033hcx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hcx.1 uc033hcx.2 
ENSMUST00000183498.3 Mir6999 ENSMUST00000183498.3 microRNA 6999 (from RefSeq NR_105965.1) ENSMUST00000183498.1 ENSMUST00000183498.2 NR_105965 uc033hoi.1 uc033hoi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hoi.1 uc033hoi.2 
ENSMUST00000183506.3 Mir7000 ENSMUST00000183506.3 microRNA 7000 (from RefSeq NR_105966.1) ENSMUST00000183506.1 ENSMUST00000183506.2 NR_105966 uc033hoj.1 uc033hoj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hoj.1 uc033hoj.2 
ENSMUST00000183508.3 Gm27549 ENSMUST00000183508.3 Gm27549 (from geneSymbol) ENSMUST00000183508.1 ENSMUST00000183508.2 uc291dwa.1 uc291dwa.2 uc291dwa.1 uc291dwa.2 
ENSMUST00000183510.3 Mir6370 ENSMUST00000183510.3 microRNA 6370 (from RefSeq NR_105789.1) ENSMUST00000183510.1 ENSMUST00000183510.2 NR_105789 uc033iog.1 uc033iog.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iog.1 uc033iog.2 
ENSMUST00000183512.2 Gm10603 ENSMUST00000183512.2 Gm10603 (from geneSymbol) AK040808 ENSMUST00000183512.1 uc009imz.1 uc009imz.2 uc009imz.1 uc009imz.2 
ENSMUST00000183515.3 Mir6946 ENSMUST00000183515.3 microRNA 6946 (from RefSeq NR_105911.1) ENSMUST00000183515.1 ENSMUST00000183515.2 NR_105911 uc033goo.1 uc033goo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033goo.1 uc033goo.2 
ENSMUST00000183519.3 Mir7076 ENSMUST00000183519.3 microRNA 7076 (from RefSeq NR_106044.1) ENSMUST00000183519.1 ENSMUST00000183519.2 NR_106044 uc033jhx.1 uc033jhx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jhx.1 uc033jhx.2 
ENSMUST00000183523.3 Mir7676-2 ENSMUST00000183523.3 microRNA 7676-2 (from RefSeq NR_106138.1) ENSMUST00000183523.1 ENSMUST00000183523.2 NR_106138 uc033guy.1 uc033guy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033guy.1 uc033guy.2 
ENSMUST00000183526.3 Mir7082 ENSMUST00000183526.3 microRNA 7082 (from RefSeq NR_106050.1) ENSMUST00000183526.1 ENSMUST00000183526.2 NR_106050 uc033jjh.1 uc033jjh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jjh.1 uc033jjh.2 
ENSMUST00000183535.3 Mir6963 ENSMUST00000183535.3 microRNA 6963 (from RefSeq NR_105928.1) ENSMUST00000183535.1 ENSMUST00000183535.2 NR_105928 uc033gxd.1 uc033gxd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gxd.1 uc033gxd.2 
ENSMUST00000183540.3 Mir7013 ENSMUST00000183540.3 microRNA 7013 (from RefSeq NR_105980.1) ENSMUST00000183540.1 ENSMUST00000183540.2 NR_105980 uc033hwx.1 uc033hwx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hwx.1 uc033hwx.2 
ENSMUST00000183541.3 Mir6356 ENSMUST00000183541.3 microRNA 6356 (from RefSeq NR_105774.1) ENSMUST00000183541.1 ENSMUST00000183541.2 NR_105774 uc033hhu.1 uc033hhu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hhu.1 uc033hhu.2 
ENSMUST00000183546.3 Mir6373 ENSMUST00000183546.3 microRNA 6373 (from RefSeq NR_105792.1) ENSMUST00000183546.1 ENSMUST00000183546.2 NR_105792 uc033itq.1 uc033itq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033itq.1 uc033itq.2 
ENSMUST00000183547.3 Mir6936 ENSMUST00000183547.3 microRNA 6936 (from RefSeq NR_105901.1) ENSMUST00000183547.1 ENSMUST00000183547.2 NR_105901 uc033gbx.1 uc033gbx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gbx.1 uc033gbx.2 
ENSMUST00000183555.3 Mir7685 ENSMUST00000183555.3 microRNA 7685 (from RefSeq NR_106156.1) ENSMUST00000183555.1 ENSMUST00000183555.2 NR_106156 uc033hrc.1 uc033hrc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hrc.1 uc033hrc.2 
ENSMUST00000183556.3 Mir6411 ENSMUST00000183556.3 microRNA 6411 (from RefSeq NR_105838.1) ENSMUST00000183556.1 ENSMUST00000183556.2 NR_105838 uc033fso.1 uc033fso.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fso.1 uc033fso.2 
ENSMUST00000183558.3 Mir6386 ENSMUST00000183558.3 microRNA 6386 (from RefSeq NR_105808.1) ENSMUST00000183558.1 ENSMUST00000183558.2 NR_105808 uc033jlz.1 uc033jlz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jlz.1 uc033jlz.2 
ENSMUST00000183564.3 Mir6239 ENSMUST00000183564.3 microRNA 6239 (from RefSeq NR_105747.1) ENSMUST00000183564.1 ENSMUST00000183564.2 NR_105747 uc033gsp.1 uc033gsp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gsp.1 uc033gsp.2 
ENSMUST00000183565.3 Mir7688 ENSMUST00000183565.3 microRNA 7688 (from RefSeq NR_106161.1) ENSMUST00000183565.1 ENSMUST00000183565.2 NR_106161 uc056yhu.1 uc056yhu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yhu.1 uc056yhu.2 
ENSMUST00000183566.3 Mir7030 ENSMUST00000183566.3 microRNA 7030 (from RefSeq NR_105997.1) ENSMUST00000183566.1 ENSMUST00000183566.2 NR_105997 uc033iln.1 uc033iln.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iln.1 uc033iln.2 
ENSMUST00000183568.3 Mir8099-2 ENSMUST00000183568.3 microRNA 8099-2 (from RefSeq NR_106201.1) ENSMUST00000183568.1 ENSMUST00000183568.2 NR_106201 uc033ges.1 uc033ges.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ges.1 uc033ges.2 
ENSMUST00000183573.5 Vsig10l2 ENSMUST00000183573.5 V-set and immunoglobulin domain containing 10 like 2 (from RefSeq NM_001378295.1) A0A140LHF2 ENSMUST00000183573.1 ENSMUST00000183573.2 ENSMUST00000183573.3 ENSMUST00000183573.4 Gm1113 NM_001378295 VSXL2_MOUSE Vsig10l2 uc292frf.1 uc292frf.2 Membrane ; Single-pass membrane protein molecular_function cellular_component biological_process membrane integral component of membrane uc292frf.1 uc292frf.2 
ENSMUST00000183581.3 Mir6336 ENSMUST00000183581.3 microRNA 6336 (from RefSeq NR_105754.1) ENSMUST00000183581.1 ENSMUST00000183581.2 NR_105754 uc033hmu.1 uc033hmu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hmu.1 uc033hmu.2 
ENSMUST00000183582.3 Mir8114 ENSMUST00000183582.3 microRNA 8114 (from RefSeq NR_106194.1) ENSMUST00000183582.1 ENSMUST00000183582.2 NR_106194 uc033fml.1 uc033fml.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fml.1 uc033fml.2 
ENSMUST00000183584.3 Mir6343 ENSMUST00000183584.3 microRNA 6343 (from RefSeq NR_105761.1) ENSMUST00000183584.1 ENSMUST00000183584.2 NR_105761 uc033fjq.1 uc033fjq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fjq.1 uc033fjq.2 
ENSMUST00000183592.3 Mir6406 ENSMUST00000183592.3 microRNA 6406 (from RefSeq NR_105833.1) ENSMUST00000183592.1 ENSMUST00000183592.2 NR_105833 uc033fwn.1 uc033fwn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fwn.1 uc033fwn.2 
ENSMUST00000183596.3 Mir6353 ENSMUST00000183596.3 microRNA 6353 (from RefSeq NR_105771.1) ENSMUST00000183596.1 ENSMUST00000183596.2 NR_105771 uc033fka.1 uc033fka.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fka.1 uc033fka.2 
ENSMUST00000183597.3 Mir6903 ENSMUST00000183597.3 microRNA 6903 (from RefSeq NR_105868.1) ENSMUST00000183597.1 ENSMUST00000183597.2 NR_105868 uc033flg.1 uc033flg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033flg.1 uc033flg.2 
ENSMUST00000183598.3 Mir6956 ENSMUST00000183598.3 microRNA 6956 (from RefSeq NR_105921.1) ENSMUST00000183598.1 ENSMUST00000183598.2 NR_105921 uc033gve.1 uc033gve.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gve.1 uc033gve.2 
ENSMUST00000183602.3 Mir8091 ENSMUST00000183602.3 microRNA 8091 (from RefSeq NR_106166.1) ENSMUST00000183602.1 ENSMUST00000183602.2 NR_106166 uc033hko.1 uc033hko.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hko.1 uc033hko.2 
ENSMUST00000183603.3 Mir6396 ENSMUST00000183603.3 microRNA 6396 (from RefSeq NR_105821.1) ENSMUST00000183603.1 ENSMUST00000183603.2 NR_105821 uc033jij.1 uc033jij.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jij.1 uc033jij.2 
ENSMUST00000183606.3 Mir7054 ENSMUST00000183606.3 microRNA 7054 (from RefSeq NR_106021.1) ENSMUST00000183606.1 ENSMUST00000183606.2 NR_106021 uc033ize.1 uc033ize.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ize.1 uc033ize.2 
ENSMUST00000183612.3 1700027I24Rik ENSMUST00000183612.3 RIKEN cDNA 1700027I24 gene (from RefSeq NR_040741.1) ENSMUST00000183612.1 ENSMUST00000183612.2 NR_040741 uc009ots.1 uc009ots.2 uc009ots.3 uc009ots.1 uc009ots.2 uc009ots.3 
ENSMUST00000183615.3 Mir6935 ENSMUST00000183615.3 microRNA 6935 (from RefSeq NR_105900.1) ENSMUST00000183615.1 ENSMUST00000183615.2 NR_105900 uc033gbw.1 uc033gbw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gbw.1 uc033gbw.2 
ENSMUST00000183616.2 Gm27240 ENSMUST00000183616.2 Gm27240 (from geneSymbol) ENSMUST00000183616.1 uc292fof.1 uc292fof.2 uc292fof.1 uc292fof.2 
ENSMUST00000183618.3 Pet117 ENSMUST00000183618.3 PET117 homolog (from RefSeq NM_001164813.1) ENSMUST00000183618.1 ENSMUST00000183618.2 Gm20571 NM_001164813 P0DJF2 PT117_MOUSE uc290azr.1 uc290azr.2 Mitochondrion Belongs to the PET117 family. mitochondrion mitochondrial respiratory chain complex IV assembly uc290azr.1 uc290azr.2 
ENSMUST00000183620.4 Mir668 ENSMUST00000183620.4 microRNA 668 (from RefSeq NR_030424.1) ENSMUST00000183620.1 ENSMUST00000183620.2 ENSMUST00000183620.3 NR_030424 uc011ytz.1 uc011ytz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609653.1 [ECO:0000345] ##Evidence-Data-END## uc011ytz.1 uc011ytz.2 
ENSMUST00000183621.2 1110008E08Rik ENSMUST00000183621.2 1110008E08Rik (from geneSymbol) AK003565 ENSMUST00000183621.1 uc289fxk.1 uc289fxk.2 uc289fxk.1 uc289fxk.2 
ENSMUST00000183624.3 Mir7006 ENSMUST00000183624.3 microRNA 7006 (from RefSeq NR_105973.1) ENSMUST00000183624.1 ENSMUST00000183624.2 NR_105973 uc033hry.1 uc033hry.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hry.1 uc033hry.2 
ENSMUST00000183632.4 1110015O18Rik ENSMUST00000183632.4 1110015O18Rik (from geneSymbol) ENSMUST00000183632.1 ENSMUST00000183632.2 ENSMUST00000183632.3 uc290dsi.1 uc290dsi.2 uc290dsi.3 uc290dsi.4 uc290dsi.1 uc290dsi.2 uc290dsi.3 uc290dsi.4 
ENSMUST00000183639.3 Mir6350 ENSMUST00000183639.3 microRNA 6350 (from RefSeq NR_105768.1) ENSMUST00000183639.1 ENSMUST00000183639.2 NR_105768 uc033fiz.1 uc033fiz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fiz.1 uc033fiz.2 
ENSMUST00000183640.3 Mir7680 ENSMUST00000183640.3 microRNA 7680 (from RefSeq NR_106145.1) ENSMUST00000183640.1 ENSMUST00000183640.2 NR_106145 uc033gyl.1 uc033gyl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gyl.1 uc033gyl.2 
ENSMUST00000183642.2 Gm27176 ENSMUST00000183642.2 Gm27176 (from geneSymbol) AK020757 ENSMUST00000183642.1 uc288vkg.1 uc288vkg.2 uc288vkg.1 uc288vkg.2 
ENSMUST00000183643.3 Mir6408 ENSMUST00000183643.3 microRNA 6408 (from RefSeq NR_105835.1) ENSMUST00000183643.1 ENSMUST00000183643.2 NR_105835 uc033fpo.1 uc033fpo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fpo.1 uc033fpo.2 
ENSMUST00000183645.2 Hm629797 ENSMUST00000183645.2 Hm629797 (from geneSymbol) ENSMUST00000183645.1 uc292btx.1 uc292btx.2 uc292btx.1 uc292btx.2 
ENSMUST00000183646.3 Mir6973a ENSMUST00000183646.3 microRNA 6973a (from RefSeq NR_105939.1) ENSMUST00000183646.1 ENSMUST00000183646.2 NR_105939 uc033hdg.1 uc033hdg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hdg.1 uc033hdg.2 
ENSMUST00000183649.3 Mir6541 ENSMUST00000183649.3 microRNA 6541 (from RefSeq NR_105860.1) ENSMUST00000183649.1 ENSMUST00000183649.2 NR_105860 uc033grm.1 uc033grm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033grm.1 uc033grm.2 
ENSMUST00000183650.3 Mir7648 ENSMUST00000183650.3 microRNA 7648 (from RefSeq NR_106106.1) ENSMUST00000183650.1 ENSMUST00000183650.2 NR_106106 uc033gwj.1 uc033gwj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gwj.1 uc033gwj.2 
ENSMUST00000183653.3 Mir6944 ENSMUST00000183653.3 microRNA 6944 (from RefSeq NR_105909.1) ENSMUST00000183653.1 ENSMUST00000183653.2 NR_105909 uc033gly.1 uc033gly.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gly.1 uc033gly.2 
ENSMUST00000183657.3 Mir7070 ENSMUST00000183657.3 microRNA 7070 (from RefSeq NR_106038.1) ENSMUST00000183657.1 ENSMUST00000183657.2 NR_106038 uc033jgl.1 uc033jgl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jgl.1 uc033jgl.2 
ENSMUST00000183658.3 Mir6995 ENSMUST00000183658.3 microRNA 6995 (from RefSeq NR_105961.1) ENSMUST00000183658.1 ENSMUST00000183658.2 NR_105961 uc033hkt.1 uc033hkt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hkt.1 uc033hkt.2 
ENSMUST00000183659.8 Nav2 ENSMUST00000183659.8 neuron navigator 2, transcript variant 2 (from RefSeq NM_001111016.1) ENSMUST00000183659.1 ENSMUST00000183659.2 ENSMUST00000183659.3 ENSMUST00000183659.4 ENSMUST00000183659.5 ENSMUST00000183659.6 ENSMUST00000183659.7 NM_001111016 Nav2 V9GXT3 V9GXT3_MOUSE uc057ahi.1 uc057ahi.2 uc057ahi.3 uc057ahi.4 Belongs to the Nav/unc-53 family. regulation of systemic arterial blood pressure by baroreceptor feedback interstitial matrix nucleoplasm nervous system development sensory perception of sound sensory perception of smell locomotory behavior heparin binding optic nerve development glossopharyngeal nerve development vagus nerve development neurogenesis extracellular matrix uc057ahi.1 uc057ahi.2 uc057ahi.3 uc057ahi.4 
ENSMUST00000183661.3 Mir6389 ENSMUST00000183661.3 microRNA 6389 (from RefSeq NR_105812.1) ENSMUST00000183661.1 ENSMUST00000183661.2 NR_105812 uc033izu.1 uc033izu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033izu.1 uc033izu.2 
ENSMUST00000183663.8 Il6st ENSMUST00000183663.8 interleukin 6 signal transducer (from RefSeq NM_010560.3) ENSMUST00000183663.1 ENSMUST00000183663.2 ENSMUST00000183663.3 ENSMUST00000183663.4 ENSMUST00000183663.5 ENSMUST00000183663.6 ENSMUST00000183663.7 G5E8D2 IL6RB_MOUSE Il6st NM_010560 Q00560 uc007rwg.1 uc007rwg.2 uc007rwg.3 uc007rwg.4 Signal-transducing molecule (PubMed:1602143). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:1602143, PubMed:10661409). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:10661409). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (PubMed:9202125). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (PubMed:25731159). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (PubMed:10661409, PubMed:26255596, PubMed:25057188, PubMed:8552649). Has a role in embryonic development (PubMed:10661409). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352). Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504). Required for normal trabecular bone mass and cortical bone composition (PubMed:24339143, PubMed:9348227, PubMed:26255596). Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; associates with the complex IL6:IL6R but does not interact with IL6 (By similarity). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM. Also forms heterodimers composed of OSMR and IL6ST (type II receptor) which are activated by OSM but not by LIF. Interacts with HCK (By similarity). Interacts with INPP5D/SHIP1 (PubMed:17105399). Interacts with SRC and YES (By similarity). Interacts with ARMH4; this interaction prevents IL6ST protein homodimerization and bridges ARMH4 with IL6R and STAT3 and therefore inhibits phosphorylation of STAT3 at 'Tyr-705' (By similarity). Q00560; O35718: Socs3; NbExp=6; IntAct=EBI-3862992, EBI-2659360; Cell membrane ; Single-pass type I membrane protein Expression not restricted to IL6-responsive cells. Found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver. Found in all the cell lines tested except BaF-B03. Expressed paraventricular nucleus of the hypothalamus (PubMed:28402851). In embryonic stem cells it is found from day 6 of gestation. It reaches a peak on day 8 and gradually declines during the rest of embryogenesis. In paraventricular nucleus of the hypothalamus, expression is enhanced by obesity. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Phosphorylation of Ser-780 down-regulates cell surface expression. Heavily N-glycosylated. Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding. Progressively lethal between 12.5 dpc and birth (PubMed:8552649). Embryos show hypoplastic ventricular myocardium without septal and trabecular defect, reduced numbers of pluripotential and committed hematopoietic progenitors in liver and reduced differentiated lineages in thymus (PubMed:8552649). Impaired differentiation of astrocytes and decreased number of dorsal root ganglion and motor neurons at 18.5 dpc (PubMed:10377352). Decreased volume of mineralized trabecular bones, while number of osteoclasts is increased (PubMed:9348227, PubMed:26255596). Conditional knockout from the entire osteoblast lineage or specifically in osteocytes causes no significant skeletal or morphological defects but mice show 30% lower trabecular bone formation rate and larger cortical diameter compared to wild type (PubMed:24339143, PubMed:26255596). Conditional knockout in primary nociceptive afferents causes reduced sensitivity to mechanical stimulation due to reduced sensitivity of nociceptive neurons and reduces TRPA1 mRNA expression in dorsal root ganglion neurons (PubMed:25057188). Belongs to the type I cytokine receptor family. Type 2 subfamily. cytokine receptor activity ciliary neurotrophic factor receptor activity interleukin-6 receptor activity leukemia inhibitory factor receptor activity oncostatin-M receptor activity ciliary neurotrophic factor receptor binding interleukin-6 receptor binding protein binding extracellular space plasma membrane interleukin-6 receptor complex oncostatin-M receptor complex glycogen metabolic process triglyceride mobilization signal transduction positive regulation of cell proliferation regulation of Notch signaling pathway external side of plasma membrane positive regulation of smooth muscle cell migration membrane integral component of membrane cytokine-mediated signaling pathway growth factor binding cytokine binding interleukin-6 binding dendrite neuronal cell body membrane response to cytokine interleukin-11-mediated signaling pathway oncostatin-M-mediated signaling pathway positive regulation of T cell proliferation positive regulation of tyrosine phosphorylation of STAT protein identical protein binding neuronal cell body receptor complex cell body positive regulation of osteoblast differentiation positive regulation of astrocyte differentiation leukemia inhibitory factor signaling pathway negative regulation of cytosolic calcium ion concentration interleukin-6-mediated signaling pathway negative regulation of interleukin-6-mediated signaling pathway interleukin-27-mediated signaling pathway ciliary neurotrophic factor receptor complex ciliary neurotrophic factor-mediated signaling pathway interleukin-11 receptor activity interleukin-11 binding uc007rwg.1 uc007rwg.2 uc007rwg.3 uc007rwg.4 
ENSMUST00000183664.3 Mir6416 ENSMUST00000183664.3 microRNA 6416 (from RefSeq NR_105844.1) ENSMUST00000183664.1 ENSMUST00000183664.2 NR_105844 uc033izz.1 uc033izz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033izz.1 uc033izz.2 
ENSMUST00000183668.3 Mir6359 ENSMUST00000183668.3 microRNA 6359 (from RefSeq NR_105777.1) ENSMUST00000183668.1 ENSMUST00000183668.2 NR_105777 uc033hic.1 uc033hic.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hic.1 uc033hic.2 
ENSMUST00000183670.2 Gm27253 ENSMUST00000183670.2 Gm27253 (from geneSymbol) AK039014 ENSMUST00000183670.1 uc009qpm.1 uc009qpm.2 uc009qpm.3 uc009qpm.1 uc009qpm.2 uc009qpm.3 
ENSMUST00000183676.3 Mir7024 ENSMUST00000183676.3 microRNA 7024 (from RefSeq NR_105991.1) ENSMUST00000183676.1 ENSMUST00000183676.2 NR_105991 uc033iit.1 uc033iit.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iit.1 uc033iit.2 
ENSMUST00000183679.3 Mir7668 ENSMUST00000183679.3 microRNA 7668 (from RefSeq NR_106128.1) ENSMUST00000183679.1 ENSMUST00000183679.2 NR_106128 uc033iyd.1 uc033iyd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iyd.1 uc033iyd.2 
ENSMUST00000183683.3 Mir7086 ENSMUST00000183683.3 microRNA 7086 (from RefSeq NR_106054.1) ENSMUST00000183683.1 ENSMUST00000183683.2 NR_106054 uc033jkc.1 uc033jkc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jkc.1 uc033jkc.2 
ENSMUST00000183685.3 Mir6414 ENSMUST00000183685.3 microRNA 6414 (from RefSeq NR_105842.1) ENSMUST00000183685.1 ENSMUST00000183685.2 NR_105842 uc033ijh.1 uc033ijh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ijh.1 uc033ijh.2 
ENSMUST00000183687.3 Mir6355 ENSMUST00000183687.3 microRNA 6355 (from RefSeq NR_105773.1) ENSMUST00000183687.1 ENSMUST00000183687.2 NR_105773 uc033hhc.1 uc033hhc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hhc.1 uc033hhc.2 
ENSMUST00000183689.3 Mir7670 ENSMUST00000183689.3 microRNA 7670 (from RefSeq NR_106130.1) ENSMUST00000183689.1 ENSMUST00000183689.2 NR_106130 uc033iou.1 uc033iou.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iou.1 uc033iou.2 
ENSMUST00000183694.8 Tmem196 ENSMUST00000183694.8 transmembrane protein 196, transcript variant 1 (from RefSeq NM_001294146.2) ENSMUST00000183694.1 ENSMUST00000183694.2 ENSMUST00000183694.3 ENSMUST00000183694.4 ENSMUST00000183694.5 ENSMUST00000183694.6 ENSMUST00000183694.7 NM_001294146 Tmem196 V9GX04 V9GX04_MOUSE uc056yst.1 uc056yst.2 uc056yst.3 molecular_function cellular_component biological_process membrane integral component of membrane uc056yst.1 uc056yst.2 uc056yst.3 
ENSMUST00000183699.3 Mir6404 ENSMUST00000183699.3 microRNA 6404 (from RefSeq NR_105830.1) ENSMUST00000183699.1 ENSMUST00000183699.2 NR_105830 uc033jdo.1 uc033jdo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jdo.1 uc033jdo.2 
ENSMUST00000183703.8 Erc1 ENSMUST00000183703.8 ELKS/RAB6-interacting/CAST family member 1, transcript variant 1 (from RefSeq NM_053204.2) ENSMUST00000183703.1 ENSMUST00000183703.2 ENSMUST00000183703.3 ENSMUST00000183703.4 ENSMUST00000183703.5 ENSMUST00000183703.6 ENSMUST00000183703.7 Erc1 F8VPM7 F8VPM7_MOUSE NM_053204 uc009dmk.1 uc009dmk.2 Cytoplasm centrosome I-kappaB phosphorylation IkappaB kinase complex ciliary basal body uc009dmk.1 uc009dmk.2 
ENSMUST00000183708.3 Mir6957 ENSMUST00000183708.3 microRNA 6957 (from RefSeq NR_105922.1) ENSMUST00000183708.1 ENSMUST00000183708.2 NR_105922 uc033gvj.1 uc033gvj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gvj.1 uc033gvj.2 
ENSMUST00000183709.3 Mir6393 ENSMUST00000183709.3 microRNA 6393 (from RefSeq NR_105817.1) ENSMUST00000183709.1 ENSMUST00000183709.2 NR_105817 uc033gvv.1 uc033gvv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gvv.1 uc033gvv.2 
ENSMUST00000183710.3 Mir7242 ENSMUST00000183710.3 microRNA 7242 (from RefSeq NR_106101.1) ENSMUST00000183710.1 ENSMUST00000183710.2 NR_106101 uc009qko.1 uc009qko.2 uc009qko.3 uc009qko.4 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc009qko.1 uc009qko.2 uc009qko.3 uc009qko.4 
ENSMUST00000183713.3 Mir6538 ENSMUST00000183713.3 microRNA 6538 (from RefSeq NR_105856.1) ENSMUST00000183713.1 ENSMUST00000183713.2 NR_105856 uc033gcw.1 uc033gcw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gcw.1 uc033gcw.2 
ENSMUST00000183718.8 Gm10637 ENSMUST00000183718.8 predicted gene 10637 (from RefSeq NR_040697.1) ENSMUST00000183718.1 ENSMUST00000183718.2 ENSMUST00000183718.3 ENSMUST00000183718.4 ENSMUST00000183718.5 ENSMUST00000183718.6 ENSMUST00000183718.7 NR_040697 uc029wue.1 uc029wue.2 uc029wue.3 uc029wue.1 uc029wue.2 uc029wue.3 
ENSMUST00000183719.3 Mir6921 ENSMUST00000183719.3 microRNA 6921 (from RefSeq NR_105886.1) ENSMUST00000183719.1 ENSMUST00000183719.2 NR_105886 uc033fvx.1 uc033fvx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fvx.1 uc033fvx.2 
ENSMUST00000183724.3 Mir6990 ENSMUST00000183724.3 microRNA 6990 (from RefSeq NR_105956.1) ENSMUST00000183724.1 ENSMUST00000183724.2 NR_105956 uc033his.1 uc033his.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033his.1 uc033his.2 
ENSMUST00000183732.3 Mir6539 ENSMUST00000183732.3 microRNA 6539 (from RefSeq NR_105857.1) ENSMUST00000183732.1 ENSMUST00000183732.2 NR_105857 uc033grr.1 uc033grr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611776.1 [ECO:0000345] ##Evidence-Data-END## uc033grr.1 uc033grr.2 
ENSMUST00000183735.3 Mir8092 ENSMUST00000183735.3 microRNA 8092 (from RefSeq NR_106167.1) ENSMUST00000183735.1 ENSMUST00000183735.2 NR_106167 uc033hkm.1 uc033hkm.2 uc033hkm.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hkm.1 uc033hkm.2 uc033hkm.3 
ENSMUST00000183740.3 Mir7222 ENSMUST00000183740.3 microRNA 7222 (from RefSeq NR_106081.1) ENSMUST00000183740.1 ENSMUST00000183740.2 NR_106081 uc008ley.1 uc008ley.2 uc008ley.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc008ley.1 uc008ley.2 uc008ley.3 
ENSMUST00000183743.3 Mir3473f ENSMUST00000183743.3 microRNA 3473f (from RefSeq NR_106164.1) ENSMUST00000183743.1 ENSMUST00000183743.2 NR_106164 uc056ydp.1 uc056ydp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056ydp.1 uc056ydp.2 
ENSMUST00000183749.3 Mir7022 ENSMUST00000183749.3 microRNA 7022 (from RefSeq NR_105989.1) ENSMUST00000183749.1 ENSMUST00000183749.2 NR_105989 uc033igr.1 uc033igr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033igr.1 uc033igr.2 
ENSMUST00000183752.3 Gm27167 ENSMUST00000183752.3 Gm27167 (from geneSymbol) ENSMUST00000183752.1 ENSMUST00000183752.2 uc292but.1 uc292but.2 uc292but.3 uc292but.1 uc292but.2 uc292but.3 
ENSMUST00000183760.3 Mir6377 ENSMUST00000183760.3 microRNA 6377 (from RefSeq NR_105797.1) ENSMUST00000183760.1 ENSMUST00000183760.2 NR_105797 uc056zsl.1 uc056zsl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zsl.1 uc056zsl.2 
ENSMUST00000183764.3 Mir6907 ENSMUST00000183764.3 microRNA 6907 (from RefSeq NR_105872.1) ENSMUST00000183764.1 ENSMUST00000183764.2 NR_105872 uc033fqq.1 uc033fqq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fqq.1 uc033fqq.2 
ENSMUST00000183768.3 Mir7011 ENSMUST00000183768.3 microRNA 7011 (from RefSeq NR_105978.1) ENSMUST00000183768.1 ENSMUST00000183768.2 NR_105978 uc033huu.1 uc033huu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033huu.1 uc033huu.2 
ENSMUST00000183771.3 Mir8110 ENSMUST00000183771.3 microRNA 8110 (from RefSeq NR_106190.1) ENSMUST00000183771.1 ENSMUST00000183771.2 NR_106190 uc033jgs.1 uc033jgs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jgs.1 uc033jgs.2 
ENSMUST00000183772.3 Mir6369 ENSMUST00000183772.3 microRNA 6369 (from RefSeq NR_105788.1) ENSMUST00000183772.1 ENSMUST00000183772.2 NR_105788 uc033gmd.1 uc033gmd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gmd.1 uc033gmd.2 
ENSMUST00000183776.3 Mir7056 ENSMUST00000183776.3 microRNA 7056 (from RefSeq NR_106023.1) ENSMUST00000183776.1 ENSMUST00000183776.2 NR_106023 uc033izo.1 uc033izo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033izo.1 uc033izo.2 
ENSMUST00000183777.3 Mir6969 ENSMUST00000183777.3 microRNA 6969 (from RefSeq NR_105935.1) ENSMUST00000183777.1 ENSMUST00000183777.2 NR_105935 uc033hck.1 uc033hck.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hck.1 uc033hck.2 
ENSMUST00000183782.10 Gm27252 ENSMUST00000183782.10 predicted gene 27252 (from RefSeq NR_166574.1) ENSMUST00000183782.1 ENSMUST00000183782.2 ENSMUST00000183782.3 ENSMUST00000183782.4 ENSMUST00000183782.5 ENSMUST00000183782.6 ENSMUST00000183782.7 ENSMUST00000183782.8 ENSMUST00000183782.9 NR_166574 uc291qxv.1 uc291qxv.2 uc291qxv.3 uc291qxv.4 uc291qxv.1 uc291qxv.2 uc291qxv.3 uc291qxv.4 
ENSMUST00000183787.3 Mir7020 ENSMUST00000183787.3 microRNA 7020 (from RefSeq NR_105987.1) ENSMUST00000183787.1 ENSMUST00000183787.2 NR_105987 uc033igh.1 uc033igh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033igh.1 uc033igh.2 
ENSMUST00000183788.8 Obox7 ENSMUST00000183788.8 oocyte specific homeobox 7 (from RefSeq NM_001038676.1) ENSMUST00000183788.1 ENSMUST00000183788.2 ENSMUST00000183788.3 ENSMUST00000183788.4 ENSMUST00000183788.5 ENSMUST00000183788.6 ENSMUST00000183788.7 Gm4745 NM_001038676 OBOX7_MOUSE Obox7 Q4KL20 V9GWX2 uc009fge.1 uc009fge.2 uc009fge.3 Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Together with other Obox family members, required in early two-cell stage embryos to kick-start the major ZGA wave by facilitating RNA Polymerase II 'pre-configuration', during which RNA Polymerase II relocates from the initial one-cell stage binding targets to ZGA gene promoters and distal enhancers (PubMed:37459895). Mechanistically, promotes recruitment of RNA Polymerase II from (CG-rich) non-ZGA genes to (CG-poor) ZGA genes at the two-cell stage (PubMed:37459895). Binds to regulatory DNA sequences containing a 5'-ACNCCTTTAATCCCAG-3' sequence motif (PubMed:37459895). Most maternal and zygotic Obox family proteins can compensate for one another (PubMed:37459895). Nucleus Specifically expressed in oocytes and early embryos. Expressed maternally with high expression in oocytes and early embryos before expression declines after zygotic genome activation (ZGA). No visible phenotype; mice are viable and fertile (PubMed:37459895). Female mice lacking maternally transcribed Obox1, Obox2, Obox5, Obox7 as well as zygotically expressed Obox3 and Obox4 are infertile: embryos arrest at two-four cell stage due to impaired zygotic genome activation (ZGA) (PubMed:37459895). Belongs to the paired homeobox family. Obox subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding uc009fge.1 uc009fge.2 uc009fge.3 
ENSMUST00000183794.3 Mir7078 ENSMUST00000183794.3 microRNA 7078 (from RefSeq NR_106046.1) ENSMUST00000183794.1 ENSMUST00000183794.2 NR_106046 uc033jib.1 uc033jib.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jib.1 uc033jib.2 
ENSMUST00000183796.3 Mir7235 ENSMUST00000183796.3 microRNA 7235 (from RefSeq NR_106094.1) ENSMUST00000183796.1 ENSMUST00000183796.2 NR_106094 uc033fzp.1 uc033fzp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fzp.1 uc033fzp.2 
ENSMUST00000183797.3 Mir7025 ENSMUST00000183797.3 microRNA 7025 (from RefSeq NR_105992.1) ENSMUST00000183797.1 ENSMUST00000183797.2 NR_105992 uc033ikb.1 uc033ikb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ikb.1 uc033ikb.2 
ENSMUST00000183804.3 Mir6348 ENSMUST00000183804.3 microRNA 6348 (from RefSeq NR_105766.1) ENSMUST00000183804.1 ENSMUST00000183804.2 NR_105766 uc033fmv.1 uc033fmv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fmv.1 uc033fmv.2 
ENSMUST00000183808.3 Mir6237 ENSMUST00000183808.3 microRNA 6237 (from RefSeq NR_105745.1) ENSMUST00000183808.1 ENSMUST00000183808.2 NR_105745 uc033jiq.1 uc033jiq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jiq.1 uc033jiq.2 
ENSMUST00000183815.3 Mir6417 ENSMUST00000183815.3 microRNA 6417 (from RefSeq NR_105845.1) ENSMUST00000183815.1 ENSMUST00000183815.2 NR_105845 uc033ijs.1 uc033ijs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ijs.1 uc033ijs.2 
ENSMUST00000183818.3 Gm27201 ENSMUST00000183818.3 Gm27201 (from geneSymbol) ENSMUST00000183818.1 ENSMUST00000183818.2 uc292fnx.1 uc292fnx.2 uc292fnx.3 uc292fnx.1 uc292fnx.2 uc292fnx.3 
ENSMUST00000183825.3 Mir7660 ENSMUST00000183825.3 microRNA 7660 (from RefSeq NR_106120.1) ENSMUST00000183825.1 ENSMUST00000183825.2 NR_106120 uc057aeg.1 uc057aeg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057aeg.1 uc057aeg.2 
ENSMUST00000183826.3 Mir6351 ENSMUST00000183826.3 microRNA 6351 (from RefSeq NR_105769.1) ENSMUST00000183826.1 ENSMUST00000183826.2 NR_105769 uc056ydd.1 uc056ydd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056ydd.1 uc056ydd.2 
ENSMUST00000183834.2 Gm27209 ENSMUST00000183834.2 Gm27209 (from geneSymbol) ENSMUST00000183834.1 uc289bkx.1 uc289bkx.2 uc289bkx.1 uc289bkx.2 
ENSMUST00000183837.3 Mir6991 ENSMUST00000183837.3 microRNA 6991 (from RefSeq NR_105957.1) ENSMUST00000183837.1 ENSMUST00000183837.2 NR_105957 uc033hiv.1 uc033hiv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hiv.1 uc033hiv.2 
ENSMUST00000183838.2 Gm27202 ENSMUST00000183838.2 Gm27202 (from geneSymbol) ENSMUST00000183838.1 uc290sio.1 uc290sio.2 uc290sio.1 uc290sio.2 
ENSMUST00000183842.3 Mir7683 ENSMUST00000183842.3 microRNA 7683 (from RefSeq NR_106151.1) ENSMUST00000183842.1 ENSMUST00000183842.2 NR_106151 uc056yfc.1 uc056yfc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yfc.1 uc056yfc.2 
ENSMUST00000183847.3 Mir7213 ENSMUST00000183847.3 microRNA 7213 (from RefSeq NR_106072.1) ENSMUST00000183847.1 ENSMUST00000183847.2 NR_106072 uc033gvg.1 uc033gvg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gvg.1 uc033gvg.2 
ENSMUST00000183849.3 Mir7666 ENSMUST00000183849.3 microRNA 7666 (from RefSeq NR_106126.1) ENSMUST00000183849.1 ENSMUST00000183849.2 NR_106126 uc033jfb.1 uc033jfb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jfb.1 uc033jfb.2 
ENSMUST00000183850.8 Kcnn2 ENSMUST00000183850.8 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, transcript variant 1 (from RefSeq NM_001312905.2) A0A1B0GT12 A0A1B0GT12_MOUSE ENSMUST00000183850.1 ENSMUST00000183850.2 ENSMUST00000183850.3 ENSMUST00000183850.4 ENSMUST00000183850.5 ENSMUST00000183850.6 ENSMUST00000183850.7 Kcnn2 NM_001312905 uc008evd.1 uc008evd.2 uc008evd.3 uc008evd.4 uc008evd.5 Membrane ; Multi- pass membrane protein calmodulin binding plasma membrane potassium ion transport cell surface calcium-activated potassium channel activity membrane integral component of membrane small conductance calcium-activated potassium channel activity protein domain specific binding protein homodimerization activity alpha-actinin binding potassium ion transmembrane transport regulation of potassium ion transmembrane transport uc008evd.1 uc008evd.2 uc008evd.3 uc008evd.4 uc008evd.5 
ENSMUST00000183852.3 Mir7039 ENSMUST00000183852.3 microRNA 7039 (from RefSeq NR_106006.1) ENSMUST00000183852.1 ENSMUST00000183852.2 NR_106006 uc033inu.1 uc033inu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033inu.1 uc033inu.2 
ENSMUST00000183853.3 Mir7014 ENSMUST00000183853.3 microRNA 7014 (from RefSeq NR_105981.1) ENSMUST00000183853.1 ENSMUST00000183853.2 NR_105981 uc033hxd.1 uc033hxd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hxd.1 uc033hxd.2 
ENSMUST00000183857.3 Mir6340 ENSMUST00000183857.3 microRNA 6340 (from RefSeq NR_105758.1) ENSMUST00000183857.1 ENSMUST00000183857.2 NR_105758 uc033hro.1 uc033hro.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hro.1 uc033hro.2 
ENSMUST00000183859.3 Mir6930 ENSMUST00000183859.3 microRNA 6930 (from RefSeq NR_105895.1) ENSMUST00000183859.1 ENSMUST00000183859.2 NR_105895 uc033gaj.1 uc033gaj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gaj.1 uc033gaj.2 
ENSMUST00000183860.3 Mir7031 ENSMUST00000183860.3 microRNA 7031 (from RefSeq NR_105998.1) ENSMUST00000183860.1 ENSMUST00000183860.2 NR_105998 uc033ilt.1 uc033ilt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ilt.1 uc033ilt.2 
ENSMUST00000183862.3 Or5d14 ENSMUST00000183862.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR28) ENSMUST00000183862.1 ENSMUST00000183862.2 Olfr1162 Or5d14 Q7TR28 Q7TR28_MOUSE uc289xxj.1 uc289xxj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxj.1 uc289xxj.2 
ENSMUST00000183864.3 Mir7656 ENSMUST00000183864.3 microRNA 7656 (from RefSeq NR_106116.1) ENSMUST00000183864.1 ENSMUST00000183864.2 NR_106116 uc033jma.1 uc033jma.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jma.1 uc033jma.2 
ENSMUST00000183866.3 Mir7667 ENSMUST00000183866.3 microRNA 7667 (from RefSeq NR_106127.1) ENSMUST00000183866.1 ENSMUST00000183866.2 NR_106127 uc056zeb.1 uc056zeb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zeb.1 uc056zeb.2 
ENSMUST00000183867.8 Lockd ENSMUST00000183867.8 Lockd (from geneSymbol) AK004447 ENSMUST00000183867.1 ENSMUST00000183867.2 ENSMUST00000183867.3 ENSMUST00000183867.4 ENSMUST00000183867.5 ENSMUST00000183867.6 ENSMUST00000183867.7 uc009elc.1 uc009elc.2 uc009elc.3 uc009elc.4 uc009elc.5 uc009elc.1 uc009elc.2 uc009elc.3 uc009elc.4 uc009elc.5 
ENSMUST00000183870.3 Mir6342 ENSMUST00000183870.3 microRNA 6342 (from RefSeq NR_105760.1) ENSMUST00000183870.1 ENSMUST00000183870.2 NR_105760 uc033fii.1 uc033fii.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fii.1 uc033fii.2 
ENSMUST00000183873.8 Lrrc1 ENSMUST00000183873.8 leucine rich repeat containing 1, transcript variant 1 (from RefSeq NM_001146048.1) ENSMUST00000183873.1 ENSMUST00000183873.2 ENSMUST00000183873.3 ENSMUST00000183873.4 ENSMUST00000183873.5 ENSMUST00000183873.6 ENSMUST00000183873.7 LRRC1_MOUSE NM_001146048 Q3UI50 Q80VQ1 Q8BKR1 Q8BUS9 uc009qtk.1 uc009qtk.2 uc009qtk.3 uc009qtk.4 Interacts with DLG1. May form a complex with DLG1 and ERBIN, where interaction between LRRC1 and ERBIN is indirect (By similarity). Cytoplasm Membrane ; Peripheral membrane protein Note=Localized at the basolateral side of epithelial cells. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80VQ1-1; Sequence=Displayed; Name=2; IsoId=Q80VQ1-2; Sequence=VSP_010914; Name=3; IsoId=Q80VQ1-3; Sequence=VSP_010915, VSP_010916; Sequence=AAH46591.1; Type=Erroneous initiation; Evidence=; cytoplasm cytosol plasma membrane membrane uc009qtk.1 uc009qtk.2 uc009qtk.3 uc009qtk.4 
ENSMUST00000183874.3 Mir6961 ENSMUST00000183874.3 microRNA 6961 (from RefSeq NR_105926.1) ENSMUST00000183874.1 ENSMUST00000183874.2 NR_105926 uc033gwv.1 uc033gwv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gwv.1 uc033gwv.2 
ENSMUST00000183876.3 Mir7084 ENSMUST00000183876.3 microRNA 7084 (from RefSeq NR_106052.1) ENSMUST00000183876.1 ENSMUST00000183876.2 NR_106052 uc033jjn.1 uc033jjn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jjn.1 uc033jjn.2 
ENSMUST00000183884.3 Mir7074 ENSMUST00000183884.3 microRNA 7074 (from RefSeq NR_106042.1) ENSMUST00000183884.1 ENSMUST00000183884.2 NR_106042 uc033jhk.1 uc033jhk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jhk.1 uc033jhk.2 
ENSMUST00000183885.3 Mir6395 ENSMUST00000183885.3 microRNA 6395 (from RefSeq NR_105820.1) ENSMUST00000183885.1 ENSMUST00000183885.2 NR_105820 uc033jey.1 uc033jey.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jey.1 uc033jey.2 
ENSMUST00000183891.3 Mir7041 ENSMUST00000183891.3 microRNA 7041 (from RefSeq NR_106008.1) ENSMUST00000183891.1 ENSMUST00000183891.2 NR_106008 uc033ito.1 uc033ito.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ito.1 uc033ito.2 
ENSMUST00000183892.3 Mir1258 ENSMUST00000183892.3 microRNA 1258 (from RefSeq NR_106160.1) ENSMUST00000183892.1 ENSMUST00000183892.2 NR_106160 uc033hha.1 uc033hha.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hha.1 uc033hha.2 
ENSMUST00000183900.3 Mir7012 ENSMUST00000183900.3 microRNA 7012 (from RefSeq NR_105979.1) ENSMUST00000183900.1 ENSMUST00000183900.2 NR_105979 uc033hva.1 uc033hva.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hva.1 uc033hva.2 
ENSMUST00000183910.3 Mir6951 ENSMUST00000183910.3 microRNA 6951 (from RefSeq NR_105916.1) ENSMUST00000183910.1 ENSMUST00000183910.2 NR_105916 uc033gto.1 uc033gto.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gto.1 uc033gto.2 
ENSMUST00000183919.3 Mir6397 ENSMUST00000183919.3 microRNA 6397 (from RefSeq NR_105823.1) ENSMUST00000183919.1 ENSMUST00000183919.2 NR_105823 uc033idl.1 uc033idl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033idl.1 uc033idl.2 
ENSMUST00000183922.3 Mir6996 ENSMUST00000183922.3 microRNA 6996 (from RefSeq NR_105962.1) ENSMUST00000183922.1 ENSMUST00000183922.2 NR_105962 uc033hma.1 uc033hma.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hma.1 uc033hma.2 
ENSMUST00000183927.3 Mir6979 ENSMUST00000183927.3 microRNA 6979 (from RefSeq NR_105945.1) ENSMUST00000183927.1 ENSMUST00000183927.2 NR_105945 uc033hgm.1 uc033hgm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hgm.1 uc033hgm.2 
ENSMUST00000183932.3 Mir3473e ENSMUST00000183932.3 microRNA 3473e (from RefSeq NR_105859.1) ENSMUST00000183932.1 ENSMUST00000183932.2 NR_105859 uc033iir.1 uc033iir.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iir.1 uc033iir.2 
ENSMUST00000183945.3 Mir8103 ENSMUST00000183945.3 microRNA 8103 (from RefSeq NR_106181.1) ENSMUST00000183945.1 ENSMUST00000183945.2 NR_106181 uc033fzo.1 uc033fzo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fzo.1 uc033fzo.2 
ENSMUST00000183950.3 Mir7663 ENSMUST00000183950.3 microRNA 7663 (from RefSeq NR_106123.1) ENSMUST00000183950.1 ENSMUST00000183950.2 NR_106123 uc033fow.1 uc033fow.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fow.1 uc033fow.2 
ENSMUST00000183952.2 Tmem185b ENSMUST00000183952.2 transmembrane protein 185B (from RefSeq NM_146103.2) ENSMUST00000183952.1 Ee3-2 Fam11b NM_146103 Q8BSP3 Q8R3R5 T185B_MOUSE uc007ciu.1 uc007ciu.2 uc007ciu.3 uc007ciu.4 Membrane ; Multi-pass membrane protein Belongs to the TMEM185 family. Sequence=BAC27267.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc007ciu.1 uc007ciu.2 uc007ciu.3 uc007ciu.4 
ENSMUST00000183962.2 Mir8118 ENSMUST00000183962.2 microRNA 8118 (from RefSeq NR_106198.1) ENSMUST00000183962.1 NR_106198 uc033iaz.1 uc033iaz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iaz.1 uc033iaz.2 
ENSMUST00000183964.3 Gm27243 ENSMUST00000183964.3 Gm27243 (from geneSymbol) ENSMUST00000183964.1 ENSMUST00000183964.2 uc290llx.1 uc290llx.2 uc290llx.3 uc290llx.1 uc290llx.2 uc290llx.3 
ENSMUST00000183965.3 Mir6934 ENSMUST00000183965.3 microRNA 6934 (from RefSeq NR_105899.1) ENSMUST00000183965.1 ENSMUST00000183965.2 NR_105899 uc033gbv.1 uc033gbv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gbv.1 uc033gbv.2 
ENSMUST00000183975.3 Mir6966 ENSMUST00000183975.3 microRNA 6966 (from RefSeq NR_105932.1) ENSMUST00000183975.1 ENSMUST00000183975.2 NR_105932 uc033hbz.1 uc033hbz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hbz.1 uc033hbz.2 
ENSMUST00000183978.3 Mir7220 ENSMUST00000183978.3 microRNA 7220 (from RefSeq NR_106079.1) ENSMUST00000183978.1 ENSMUST00000183978.2 NR_106079 uc033hhj.1 uc033hhj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hhj.1 uc033hhj.2 
ENSMUST00000183982.3 Mir6346 ENSMUST00000183982.3 microRNA 6346 (from RefSeq NR_105764.1) ENSMUST00000183982.1 ENSMUST00000183982.2 NR_105764 uc056yds.1 uc056yds.2 uc056yds.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yds.1 uc056yds.2 uc056yds.3 
ENSMUST00000183983.3 Mir7049 ENSMUST00000183983.3 microRNA 7049 (from RefSeq NR_106016.1) ENSMUST00000183983.1 ENSMUST00000183983.2 NR_106016 uc033ixx.1 uc033ixx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ixx.1 uc033ixx.2 
ENSMUST00000183986.3 Mir8101 ENSMUST00000183986.3 microRNA 8101 (from RefSeq NR_106179.1) ENSMUST00000183986.1 ENSMUST00000183986.2 NR_106179 uc033gai.1 uc033gai.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gai.1 uc033gai.2 
ENSMUST00000183990.3 Mir6365 ENSMUST00000183990.3 microRNA 6365 (from RefSeq NR_105784.1) ENSMUST00000183990.1 ENSMUST00000183990.2 NR_105784 uc033gxs.1 uc033gxs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gxs.1 uc033gxs.2 
ENSMUST00000183991.3 Mir7077 ENSMUST00000183991.3 microRNA 7077 (from RefSeq NR_106045.1) ENSMUST00000183991.1 ENSMUST00000183991.2 NR_106045 uc033jia.1 uc033jia.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jia.1 uc033jia.2 
ENSMUST00000183998.3 Mir7019 ENSMUST00000183998.3 microRNA 7019 (from RefSeq NR_105986.1) ENSMUST00000183998.1 ENSMUST00000183998.2 NR_105986 uc033iga.1 uc033iga.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iga.1 uc033iga.2 
ENSMUST00000184003.3 Mir6374 ENSMUST00000184003.3 microRNA 6374 (from RefSeq NR_105793.1) ENSMUST00000184003.1 ENSMUST00000184003.2 NR_105793 uc033iss.1 uc033iss.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iss.1 uc033iss.2 
ENSMUST00000184009.3 Mir7221 ENSMUST00000184009.3 microRNA 7221 (from RefSeq NR_106080.1) ENSMUST00000184009.1 ENSMUST00000184009.2 NR_106080 uc033hok.1 uc033hok.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hok.1 uc033hok.2 
ENSMUST00000184011.3 Mir8098 ENSMUST00000184011.3 microRNA 8098 (from RefSeq NR_106174.1) ENSMUST00000184011.1 ENSMUST00000184011.2 NR_106174 uc033grl.1 uc033grl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033grl.1 uc033grl.2 
ENSMUST00000184016.3 Cphx1 ENSMUST00000184016.3 cytoplasmic polyadenylated homeobox 1 (from RefSeq NM_175342.3) Cphx Cphx1 ENSMUST00000184016.1 ENSMUST00000184016.2 Eso1 NM_175342 Q8BX39 Q8BX39_MOUSE uc007srz.1 uc007srz.2 uc007srz.3 uc007srz.4 uc007srz.5 uc007srz.6 Nucleus molecular_function DNA binding cellular_component nucleus regulation of transcription from RNA polymerase II promoter biological_process RSC complex neuron differentiation sequence-specific DNA binding uc007srz.1 uc007srz.2 uc007srz.3 uc007srz.4 uc007srz.5 uc007srz.6 
ENSMUST00000184022.3 Gm27521 ENSMUST00000184022.3 Gm27521 (from geneSymbol) ENSMUST00000184022.1 ENSMUST00000184022.2 uc290nwz.1 uc290nwz.2 uc290nwz.1 uc290nwz.2 
ENSMUST00000184024.3 Mir8107 ENSMUST00000184024.3 microRNA 8107 (from RefSeq NR_106186.1) ENSMUST00000184024.1 ENSMUST00000184024.2 NR_106186 uc033jnh.1 uc033jnh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jnh.1 uc033jnh.2 
ENSMUST00000184035.8 Pigb ENSMUST00000184035.8 phosphatidylinositol glycan anchor biosynthesis, class B, transcript variant 1 (from RefSeq NM_018889.4) ENSMUST00000184035.1 ENSMUST00000184035.2 ENSMUST00000184035.3 ENSMUST00000184035.4 ENSMUST00000184035.5 ENSMUST00000184035.6 ENSMUST00000184035.7 NM_018889 PIGB_MOUSE Q3U585 Q7TQ01 Q9JJQ0 uc292isl.1 uc292isl.2 Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2- GlcN-acyl-PI during GPI precursor assembly (By similarity). Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Endoplasmic reticulum membrane ; Multi-pass membrane protein Belongs to the glycosyltransferase 22 family. PIGB subfamily. mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane GPI anchor metabolic process GPI anchor biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups mannosylation uc292isl.1 uc292isl.2 
ENSMUST00000184042.3 Mir6387 ENSMUST00000184042.3 microRNA 6387 (from RefSeq NR_105809.1) ENSMUST00000184042.1 ENSMUST00000184042.2 NR_105809 uc033gcu.1 uc033gcu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gcu.1 uc033gcu.2 
ENSMUST00000184043.3 Mir7658 ENSMUST00000184043.3 microRNA 7658 (from RefSeq NR_106118.1) ENSMUST00000184043.1 ENSMUST00000184043.2 NR_106118 uc033ihj.1 uc033ihj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ihj.1 uc033ihj.2 
ENSMUST00000184044.3 Mir7053 ENSMUST00000184044.3 microRNA 7053 (from RefSeq NR_106020.1) ENSMUST00000184044.1 ENSMUST00000184044.2 NR_106020 uc033izb.1 uc033izb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033izb.1 uc033izb.2 
ENSMUST00000184048.3 Mir7243 ENSMUST00000184048.3 microRNA 7243 (from RefSeq NR_106163.1) ENSMUST00000184048.1 ENSMUST00000184048.2 NR_106163 uc033jmm.1 uc033jmm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jmm.1 uc033jmm.2 
ENSMUST00000184049.3 Mir6413 ENSMUST00000184049.3 microRNA 6413 (from RefSeq NR_105840.1) ENSMUST00000184049.1 ENSMUST00000184049.2 NR_105840 uc033fou.1 uc033fou.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fou.1 uc033fou.2 
ENSMUST00000184050.3 Mir6399 ENSMUST00000184050.3 microRNA 6399 (from RefSeq NR_105825.1) ENSMUST00000184050.1 ENSMUST00000184050.2 NR_105825 uc033ify.1 uc033ify.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611681.1 [ECO:0000345] ##Evidence-Data-END## uc033ify.1 uc033ify.2 
ENSMUST00000184056.3 Mir6908 ENSMUST00000184056.3 microRNA 6908 (from RefSeq NR_105873.1) ENSMUST00000184056.1 ENSMUST00000184056.2 NR_105873 uc033fqs.1 uc033fqs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fqs.1 uc033fqs.2 
ENSMUST00000184059.3 Mir6349 ENSMUST00000184059.3 microRNA 6349 (from RefSeq NR_105767.1) ENSMUST00000184059.1 ENSMUST00000184059.2 NR_105767 uc033fiv.1 uc033fiv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fiv.1 uc033fiv.2 
ENSMUST00000184063.3 Csmd2 ENSMUST00000184063.3 CUB and Sushi multiple domains 2 (from RefSeq NM_001281955.1) Csmd2 ENSMUST00000184063.1 ENSMUST00000184063.2 NM_001281955 V9GX34 V9GX34_MOUSE uc033ies.1 uc033ies.2 Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function cellular_component biological_process membrane integral component of membrane uc033ies.1 uc033ies.2 
ENSMUST00000184064.3 Mir6415 ENSMUST00000184064.3 microRNA 6415 (from RefSeq NR_105843.1) ENSMUST00000184064.1 ENSMUST00000184064.2 NR_105843 uc033ikl.1 uc033ikl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ikl.1 uc033ikl.2 
ENSMUST00000184065.10 Gm27187 ENSMUST00000184065.10 Gm27187 (from geneSymbol) ENSMUST00000184065.1 ENSMUST00000184065.2 ENSMUST00000184065.3 ENSMUST00000184065.4 ENSMUST00000184065.5 ENSMUST00000184065.6 ENSMUST00000184065.7 ENSMUST00000184065.8 ENSMUST00000184065.9 uc292fru.1 uc292fru.2 uc292fru.3 uc292fru.1 uc292fru.2 uc292fru.3 
ENSMUST00000184068.3 Mir133c ENSMUST00000184068.3 microRNA 133c (from RefSeq NR_105753.1) ENSMUST00000184068.1 ENSMUST00000184068.2 NR_105753 uc033hmf.1 uc033hmf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hmf.1 uc033hmf.2 
ENSMUST00000184071.3 Mir7211 ENSMUST00000184071.3 microRNA 7211 (from RefSeq NR_106070.1) ENSMUST00000184071.1 ENSMUST00000184071.2 NR_106070 uc033fsh.1 uc033fsh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fsh.1 uc033fsh.2 
ENSMUST00000184073.2 1110035H17Rik ENSMUST00000184073.2 1110035H17Rik (from geneSymbol) ENSMUST00000184073.1 LF196165 uc291nov.1 uc291nov.2 uc291nov.1 uc291nov.2 
ENSMUST00000184074.3 Mir7240 ENSMUST00000184074.3 microRNA 7240 (from RefSeq NR_106099.1) ENSMUST00000184074.1 ENSMUST00000184074.2 NR_106099 uc033jfz.1 uc033jfz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jfz.1 uc033jfz.2 
ENSMUST00000184075.3 Mir7091 ENSMUST00000184075.3 microRNA 7091 (from RefSeq NR_106059.1) ENSMUST00000184075.1 ENSMUST00000184075.2 NR_106059 uc033jqr.1 uc033jqr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jqr.1 uc033jqr.2 
ENSMUST00000184079.3 Mir7659 ENSMUST00000184079.3 microRNA 7659 (from RefSeq NR_106119.1) ENSMUST00000184079.1 ENSMUST00000184079.2 NR_106119 uc056yhl.1 uc056yhl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yhl.1 uc056yhl.2 
ENSMUST00000184081.3 Mir6335 ENSMUST00000184081.3 microRNA 6335 (from RefSeq NR_105752.1) ENSMUST00000184081.1 ENSMUST00000184081.2 NR_105752 uc033hni.1 uc033hni.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hni.1 uc033hni.2 
ENSMUST00000184083.2 Anxa11os ENSMUST00000184083.2 Anxa11os (from geneSymbol) AK015329 ENSMUST00000184083.1 uc288rpt.1 uc288rpt.2 uc288rpt.1 uc288rpt.2 
ENSMUST00000184090.3 Mir6910 ENSMUST00000184090.3 microRNA 6910 (from RefSeq NR_105875.1) ENSMUST00000184090.1 ENSMUST00000184090.2 NR_105875 uc033fqx.1 uc033fqx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fqx.1 uc033fqx.2 
ENSMUST00000184098.3 Mir7212 ENSMUST00000184098.3 microRNA 7212 (from RefSeq NR_106071.1) ENSMUST00000184098.1 ENSMUST00000184098.2 NR_106071 uc033gti.1 uc033gti.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gti.1 uc033gti.2 
ENSMUST00000184111.3 Mir6917 ENSMUST00000184111.3 microRNA 6917 (from RefSeq NR_105882.1) ENSMUST00000184111.1 ENSMUST00000184111.2 NR_105882 uc033ftj.1 uc033ftj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ftj.1 uc033ftj.2 
ENSMUST00000184114.3 Mir1668 ENSMUST00000184114.3 microRNA 1668 (from RefSeq NR_106188.1) ENSMUST00000184114.1 ENSMUST00000184114.2 NR_106188 uc292bll.1 uc292bll.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc292bll.1 uc292bll.2 
ENSMUST00000184115.3 Mir7k ENSMUST00000184115.3 microRNA 7k (from RefSeq NR_105854.1) ENSMUST00000184115.1 ENSMUST00000184115.2 NR_105854 uc033inv.1 uc033inv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033inv.1 uc033inv.2 
ENSMUST00000184125.8 Tex9 ENSMUST00000184125.8 testis expressed gene 9 (from RefSeq NM_009359.4) B2RUA2 ENSMUST00000184125.1 ENSMUST00000184125.2 ENSMUST00000184125.3 ENSMUST00000184125.4 ENSMUST00000184125.5 ENSMUST00000184125.6 ENSMUST00000184125.7 NM_009359 O54764 Q9D845 TEX9_MOUSE uc009qqa.1 uc009qqa.2 uc009qqa.3 uc009qqa.4 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D845-1; Sequence=Displayed; Name=2; IsoId=Q9D845-2; Sequence=VSP_019570, VSP_019571, VSP_019572; Testis-specific. molecular_function cellular_component biological_process uc009qqa.1 uc009qqa.2 uc009qqa.3 uc009qqa.4 
ENSMUST00000184126.3 Pigbos1 ENSMUST00000184126.3 Pigb opposite strand 1 (from RefSeq NM_001308425.1) A0A5F8MPY0 A0A5F8MPY0_MOUSE ENSMUST00000184126.1 ENSMUST00000184126.2 NM_001308425 Pigbos1 mCG_1034862 uc292iss.1 uc292iss.2 uc292iss.1 uc292iss.2 
ENSMUST00000184134.3 Mir8116 ENSMUST00000184134.3 microRNA 8116 (from RefSeq NR_106196.1) ENSMUST00000184134.1 ENSMUST00000184134.2 NR_106196 uc033imy.1 uc033imy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033imy.1 uc033imy.2 
ENSMUST00000184136.3 Mir6368 ENSMUST00000184136.3 microRNA 6368 (from RefSeq NR_105787.1) ENSMUST00000184136.1 ENSMUST00000184136.2 NR_105787 uc033gld.1 uc033gld.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gld.1 uc033gld.2 
ENSMUST00000184137.2 Kif7 ENSMUST00000184137.2 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (from UniProt E9QMU1) BC141045 E9QMU1 E9QMU1_MOUSE ENSMUST00000184137.1 Kif7 uc291rrv.1 uc291rrv.2 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding motor activity microtubule motor activity ATP binding microtubule-based movement microtubule binding uc291rrv.1 uc291rrv.2 
ENSMUST00000184140.3 Mir6238 ENSMUST00000184140.3 microRNA 6238 (from RefSeq NR_105746.1) ENSMUST00000184140.1 ENSMUST00000184140.2 NR_105746 uc033izt.1 uc033izt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033izt.1 uc033izt.2 
ENSMUST00000184146.8 Rab27a ENSMUST00000184146.8 RAB27A, member RAS oncogene family, transcript variant 1 (from RefSeq NM_001301230.1) ENSMUST00000184146.1 ENSMUST00000184146.2 ENSMUST00000184146.3 ENSMUST00000184146.4 ENSMUST00000184146.5 ENSMUST00000184146.6 ENSMUST00000184146.7 NM_001301230 Q9ERI2 RB27A_MOUSE uc009qqw.1 uc009qqw.2 uc009qqw.3 uc009qqw.4 The protein encoded by this gene is a member of the Rab family of proteins, which is the largest family within the Ras superfamily of GTPases. This gene product is thought to regulate vesicular transport, together with its specific effectors. Mutations in this gene cause several defects, including actin-based melanosome transport defects and immunodeficiency. Mutations in the human ortholog of this gene are associated with Griscelli syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Activated by GEFs such as DENND10. Binds SYTL1, SYTL2, SLAC2B, MYRIP, SYTL3, SYTL4, SYTL5 and MLPH. Interacts with UNC13D. Interacts with RPH3A and RPH3A. Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4) (By similarity). Interacts (GDP-bound form preferentially) with DENND10 (By similarity). Q9ERI2; Q91V27: Mlph; NbExp=2; IntAct=EBI-398172, EBI-398308; Q9ERI2; P47708: Rph3a; NbExp=2; IntAct=EBI-398172, EBI-398376; Q9ERI2; Q9R0Q1-1: Sytl4; NbExp=2; IntAct=EBI-398172, EBI-15734647; Q9ERI2; Q9HCH5: SYTL2; Xeno; NbExp=4; IntAct=EBI-398172, EBI-2690103; Q9ERI2; Q8TDW5: SYTL5; Xeno; NbExp=2; IntAct=EBI-398172, EBI-2939487; Membrane ; Lipid- anchor Melanosome Late endosome Lysosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles. Detected in melanocytes. Expressed abundantly in the stomach and is predominantly localized at the apical region of gastric-surface mucus cells. Also expressed in the thymus and lung. Belongs to the small GTPase superfamily. Rab family. nucleotide binding photoreceptor outer segment GTPase activity protein binding GTP binding lysosome endosome late endosome Golgi apparatus protein targeting intracellular protein transport exocytosis blood coagulation positive regulation of gene expression membrane vesicle-mediated transport apical plasma membrane GDP binding antigen processing and presentation protein domain specific binding secretory granule melanocyte differentiation dendrite secretory granule membrane myosin V binding melanosome localization melanosome transport Rab protein signal transduction multivesicular body membrane Weibel-Palade body multivesicular body organization melanosome cytotoxic T cell degranulation natural killer cell degranulation pigmentation positive regulation of exocytosis positive regulation of phagocytosis pigment granule localization pigment granule transport exocytic vesicle multivesicular body sorting pathway complement-dependent cytotoxicity positive regulation of regulated secretory pathway positive regulation of reactive oxygen species biosynthetic process positive regulation of constitutive secretory pathway exosomal secretion uc009qqw.1 uc009qqw.2 uc009qqw.3 uc009qqw.4 
ENSMUST00000184148.3 Mir8102 ENSMUST00000184148.3 microRNA 8102 (from RefSeq NR_106180.1) ENSMUST00000184148.1 ENSMUST00000184148.2 NR_106180 uc033fzt.1 uc033fzt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fzt.1 uc033fzt.2 
ENSMUST00000184150.3 Mir6537 ENSMUST00000184150.3 microRNA 6537 (from RefSeq NR_105855.1) ENSMUST00000184150.1 ENSMUST00000184150.2 NR_105855 uc291mxs.1 uc291mxs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc291mxs.1 uc291mxs.2 
ENSMUST00000184154.3 Mir7651 ENSMUST00000184154.3 microRNA 7651 (from RefSeq NR_106109.1) ENSMUST00000184154.1 ENSMUST00000184154.2 NR_106109 uc056yjr.1 uc056yjr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yjr.1 uc056yjr.2 
ENSMUST00000184156.3 Mir6244 ENSMUST00000184156.3 microRNA 6244 (from RefSeq NR_105750.1) ENSMUST00000184156.1 ENSMUST00000184156.2 NR_105750 uc033jkk.1 uc033jkk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jkk.1 uc033jkk.2 
ENSMUST00000184158.3 Mir7063 ENSMUST00000184158.3 microRNA 7063 (from RefSeq NR_106030.1) ENSMUST00000184158.1 ENSMUST00000184158.2 NR_106030 uc033jde.1 uc033jde.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jde.1 uc033jde.2 
ENSMUST00000184161.2 2010110E17Rik ENSMUST00000184161.2 2010110E17Rik (from geneSymbol) ENSMUST00000184161.1 LF197112 uc292bus.1 uc292bus.2 uc292bus.1 uc292bus.2 
ENSMUST00000184167.3 Mir7051 ENSMUST00000184167.3 microRNA 7051 (from RefSeq NR_106018.1) ENSMUST00000184167.1 ENSMUST00000184167.2 NR_106018 uc033iyx.1 uc033iyx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iyx.1 uc033iyx.2 
ENSMUST00000184173.3 Mir6938 ENSMUST00000184173.3 microRNA 6938 (from RefSeq NR_105903.1) ENSMUST00000184173.1 ENSMUST00000184173.2 NR_105903 uc033gef.1 uc033gef.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gef.1 uc033gef.2 
ENSMUST00000184178.3 Mir7225 ENSMUST00000184178.3 microRNA 7225 (from RefSeq NR_106084.1) ENSMUST00000184178.1 ENSMUST00000184178.2 NR_106084 uc033hyn.1 uc033hyn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hyn.1 uc033hyn.2 
ENSMUST00000184185.3 Mir6973b ENSMUST00000184185.3 microRNA 6973b (from RefSeq NR_105969.1) ENSMUST00000184185.1 ENSMUST00000184185.2 NR_105969 uc033hqg.1 uc033hqg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hqg.1 uc033hqg.2 
ENSMUST00000184187.3 Mir7075 ENSMUST00000184187.3 microRNA 7075 (from RefSeq NR_106043.1) ENSMUST00000184187.1 ENSMUST00000184187.2 NR_106043 uc033jhn.1 uc033jhn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jhn.1 uc033jhn.2 
ENSMUST00000184189.3 Rgs21 ENSMUST00000184189.3 regulator of G-protein signalling 21, transcript variant 4 (from RefSeq NM_001421025.1) ENSMUST00000184189.1 ENSMUST00000184189.2 NM_001421025 Rgs21 V9GXQ3 V9GXQ3_MOUSE uc287mjc.1 uc287mjc.2 uc287mjc.1 uc287mjc.2 
ENSMUST00000184194.3 Mir6337 ENSMUST00000184194.3 microRNA 6337 (from RefSeq NR_105755.1) ENSMUST00000184194.1 ENSMUST00000184194.2 NR_105755 uc033hnd.1 uc033hnd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hnd.1 uc033hnd.2 
ENSMUST00000184195.3 Mir7093 ENSMUST00000184195.3 microRNA 7093 (from RefSeq NR_106061.1) ENSMUST00000184195.1 ENSMUST00000184195.2 NR_106061 uc033jsu.1 uc033jsu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jsu.1 uc033jsu.2 
ENSMUST00000184197.3 Mir7036 ENSMUST00000184197.3 microRNA 7036 (from RefSeq NR_106003.1) ENSMUST00000184197.1 ENSMUST00000184197.2 NR_106003 uc033imz.1 uc033imz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033imz.1 uc033imz.2 
ENSMUST00000184202.3 Mir7224 ENSMUST00000184202.3 microRNA 7224 (from RefSeq NR_106083.1) ENSMUST00000184202.1 ENSMUST00000184202.2 NR_106083 uc033hnh.1 uc033hnh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hnh.1 uc033hnh.2 
ENSMUST00000184204.3 Mir6410 ENSMUST00000184204.3 microRNA 6410 (from RefSeq NR_105837.1) ENSMUST00000184204.1 ENSMUST00000184204.2 NR_105837 uc033fqr.1 uc033fqr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fqr.1 uc033fqr.2 
ENSMUST00000184207.3 Mir6958 ENSMUST00000184207.3 microRNA 6958 (from RefSeq NR_105923.1) ENSMUST00000184207.1 ENSMUST00000184207.2 NR_105923 uc033gwa.1 uc033gwa.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gwa.1 uc033gwa.2 
ENSMUST00000184212.3 Mir6909 ENSMUST00000184212.3 microRNA 6909 (from RefSeq NR_105874.1) ENSMUST00000184212.1 ENSMUST00000184212.2 NR_105874 uc033fqu.1 uc033fqu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fqu.1 uc033fqu.2 
ENSMUST00000184219.3 Mir7043 ENSMUST00000184219.3 microRNA 7043 (from RefSeq NR_106010.1) ENSMUST00000184219.1 ENSMUST00000184219.2 NR_106010 uc033iue.1 uc033iue.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iue.1 uc033iue.2 
ENSMUST00000184225.3 Mir6241 ENSMUST00000184225.3 microRNA 6241 (from RefSeq NR_105749.1) ENSMUST00000184225.1 ENSMUST00000184225.2 NR_105749 uc033gsr.1 uc033gsr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gsr.1 uc033gsr.2 
ENSMUST00000184226.3 Mir7677 ENSMUST00000184226.3 microRNA 7677 (from RefSeq NR_106142.1) ENSMUST00000184226.1 ENSMUST00000184226.2 NR_106142 uc033hcg.1 uc033hcg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hcg.1 uc033hcg.2 
ENSMUST00000184227.3 Mir7088 ENSMUST00000184227.3 microRNA 7088 (from RefSeq NR_106056.1) ENSMUST00000184227.1 ENSMUST00000184227.2 NR_106056 uc033jmy.1 uc033jmy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jmy.1 uc033jmy.2 
ENSMUST00000184228.3 Mir6905 ENSMUST00000184228.3 microRNA 6905 (from RefSeq NR_105870.1) ENSMUST00000184228.1 ENSMUST00000184228.2 NR_105870 uc033foy.1 uc033foy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033foy.1 uc033foy.2 
ENSMUST00000184229.3 7630403G23Rik ENSMUST00000184229.3 RIKEN cDNA 7630403G23 gene (from RefSeq NR_040744.1) ENSMUST00000184229.1 ENSMUST00000184229.2 NR_040744 uc009ose.1 uc009ose.2 uc009ose.3 uc009ose.4 uc009ose.1 uc009ose.2 uc009ose.3 uc009ose.4 
ENSMUST00000184230.3 Mir8100 ENSMUST00000184230.3 microRNA 8100 (from RefSeq NR_106177.1) ENSMUST00000184230.1 ENSMUST00000184230.2 NR_106177 uc033fuk.1 uc033fuk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fuk.1 uc033fuk.2 
ENSMUST00000184232.3 Mir378d ENSMUST00000184232.3 microRNA 378d (from RefSeq NR_105841.1) ENSMUST00000184232.1 ENSMUST00000184232.2 NR_105841 uc056yiu.1 uc056yiu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yiu.1 uc056yiu.2 
ENSMUST00000184238.3 Mir8099-1 ENSMUST00000184238.3 microRNA 8099-1 (from RefSeq NR_106175.1) ENSMUST00000184238.1 ENSMUST00000184238.2 NR_106175 uc033hwy.1 uc033hwy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hwy.1 uc033hwy.2 
ENSMUST00000184241.3 Mir6911 ENSMUST00000184241.3 microRNA 6911 (from RefSeq NR_105876.1) ENSMUST00000184241.1 ENSMUST00000184241.2 NR_105876 uc033frb.1 uc033frb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033frb.1 uc033frb.2 
ENSMUST00000184244.3 Mir6913 ENSMUST00000184244.3 microRNA 6913 (from RefSeq NR_105878.1) ENSMUST00000184244.1 ENSMUST00000184244.2 NR_105878 uc033frm.1 uc033frm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033frm.1 uc033frm.2 
ENSMUST00000184246.3 Mir6357 ENSMUST00000184246.3 microRNA 6357 (from RefSeq NR_105775.1) ENSMUST00000184246.1 ENSMUST00000184246.2 NR_105775 uc033hhy.1 uc033hhy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hhy.1 uc033hhy.2 
ENSMUST00000184251.3 Mir5124b ENSMUST00000184251.3 microRNA 5124b (from RefSeq NR_105811.1) ENSMUST00000184251.1 ENSMUST00000184251.2 NR_105811 uc056yvs.1 uc056yvs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yvs.1 uc056yvs.2 
ENSMUST00000184259.3 Mir7033 ENSMUST00000184259.3 microRNA 7033 (from RefSeq NR_106000.1) ENSMUST00000184259.1 ENSMUST00000184259.2 NR_106000 uc033imr.1 uc033imr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033imr.1 uc033imr.2 
ENSMUST00000184260.2 Gm27244 ENSMUST00000184260.2 Gm27244 (from geneSymbol) ENSMUST00000184260.1 uc290itz.1 uc290itz.2 uc290itz.1 uc290itz.2 
ENSMUST00000184262.3 Mir7675 ENSMUST00000184262.3 microRNA 7675 (from RefSeq NR_106136.1) ENSMUST00000184262.1 ENSMUST00000184262.2 NR_106136 uc033gcs.1 uc033gcs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gcs.1 uc033gcs.2 
ENSMUST00000184271.2 Calm5 ENSMUST00000184271.2 calmodulin 5 (from RefSeq NM_001008706.2) Calm5 ENSMUST00000184271.1 NM_001008706 Q6W3E0 Q6W3E0_MOUSE Scarf2 uc011yvy.1 uc011yvy.2 uc011yvy.3 calcium ion binding calcium-mediated signaling uc011yvy.1 uc011yvy.2 uc011yvy.3 
ENSMUST00000184275.3 Mir7115 ENSMUST00000184275.3 microRNA 7115 (from RefSeq NR_106064.1) ENSMUST00000184275.1 ENSMUST00000184275.2 NR_106064 uc033fxm.1 uc033fxm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fxm.1 uc033fxm.2 
ENSMUST00000184278.3 Mir6360 ENSMUST00000184278.3 microRNA 6360 (from RefSeq NR_105778.1) ENSMUST00000184278.1 ENSMUST00000184278.2 NR_105778 uc033hfy.1 uc033hfy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hfy.1 uc033hfy.2 
ENSMUST00000184281.3 Mir6240 ENSMUST00000184281.3 microRNA 6240 (from RefSeq NR_105748.1) ENSMUST00000184281.1 ENSMUST00000184281.2 NR_105748 uc057abg.1 uc057abg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057abg.1 uc057abg.2 
ENSMUST00000184283.3 Gm27195 ENSMUST00000184283.3 Gm27195 (from geneSymbol) ENSMUST00000184283.1 ENSMUST00000184283.2 uc290jpj.1 uc290jpj.2 uc290jpj.3 uc290jpj.1 uc290jpj.2 uc290jpj.3 
ENSMUST00000184284.3 Mir7018 ENSMUST00000184284.3 microRNA 7018 (from RefSeq NR_105985.1) ENSMUST00000184284.1 ENSMUST00000184284.2 NR_105985 uc033ifv.1 uc033ifv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ifv.1 uc033ifv.2 
ENSMUST00000184286.3 Mir6345 ENSMUST00000184286.3 microRNA 6345 (from RefSeq NR_105763.1) ENSMUST00000184286.1 ENSMUST00000184286.2 NR_105763 uc033fkt.1 uc033fkt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fkt.1 uc033fkt.2 
ENSMUST00000184288.3 5830468F06Rik ENSMUST00000184288.3 5830468F06Rik (from geneSymbol) AK018042 ENSMUST00000184288.1 ENSMUST00000184288.2 uc291ylx.1 uc291ylx.2 uc291ylx.3 uc291ylx.1 uc291ylx.2 uc291ylx.3 
ENSMUST00000184293.3 Mir6981 ENSMUST00000184293.3 microRNA 6981 (from RefSeq NR_105947.1) ENSMUST00000184293.1 ENSMUST00000184293.2 NR_105947 uc033hgn.1 uc033hgn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hgn.1 uc033hgn.2 
ENSMUST00000184295.3 Mir6385 ENSMUST00000184295.3 microRNA 6385 (from RefSeq NR_105806.1) ENSMUST00000184295.1 ENSMUST00000184295.2 NR_105806 uc033jkw.1 uc033jkw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jkw.1 uc033jkw.2 
ENSMUST00000184300.3 Mir6945 ENSMUST00000184300.3 microRNA 6945 (from RefSeq NR_105910.1) ENSMUST00000184300.1 ENSMUST00000184300.2 NR_105910 uc033glz.1 uc033glz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033glz.1 uc033glz.2 
ENSMUST00000184308.3 Mir7016 ENSMUST00000184308.3 microRNA 7016 (from RefSeq NR_105983.1) ENSMUST00000184308.1 ENSMUST00000184308.2 NR_105983 uc033iex.1 uc033iex.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iex.1 uc033iex.2 
ENSMUST00000184313.3 Mir6997 ENSMUST00000184313.3 microRNA 6997 (from RefSeq NR_105963.1) ENSMUST00000184313.1 ENSMUST00000184313.2 NR_105963 uc033hmi.1 uc033hmi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hmi.1 uc033hmi.2 
ENSMUST00000184317.3 Mir21b ENSMUST00000184317.3 microRNA 21b (from RefSeq NR_105796.1) ENSMUST00000184317.1 ENSMUST00000184317.2 NR_105796 uc033hso.1 uc033hso.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hso.1 uc033hso.2 
ENSMUST00000184329.3 Mir6362 ENSMUST00000184329.3 microRNA 6362 (from RefSeq NR_105781.1) ENSMUST00000184329.1 ENSMUST00000184329.2 NR_105781 uc056zbn.1 uc056zbn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zbn.1 uc056zbn.2 
ENSMUST00000184334.3 Mir6380 ENSMUST00000184334.3 microRNA 6380 (from RefSeq NR_105801.1) ENSMUST00000184334.1 ENSMUST00000184334.2 NR_105801 uc056zum.1 uc056zum.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zum.1 uc056zum.2 
ENSMUST00000184338.3 Mir6988 ENSMUST00000184338.3 microRNA 6988 (from RefSeq NR_105954.1) ENSMUST00000184338.1 ENSMUST00000184338.2 NR_105954 uc033hir.1 uc033hir.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hir.1 uc033hir.2 
ENSMUST00000184349.3 Mir7672 ENSMUST00000184349.3 microRNA 7672 (from RefSeq NR_106132.1) ENSMUST00000184349.1 ENSMUST00000184349.2 NR_106132 uc033gor.1 uc033gor.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gor.1 uc033gor.2 
ENSMUST00000184353.3 Mir7085 ENSMUST00000184353.3 microRNA 7085 (from RefSeq NR_106053.1) ENSMUST00000184353.1 ENSMUST00000184353.2 NR_106053 uc033jkb.1 uc033jkb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jkb.1 uc033jkb.2 
ENSMUST00000184354.3 Mir6982 ENSMUST00000184354.3 microRNA 6982 (from RefSeq NR_105948.1) ENSMUST00000184354.1 ENSMUST00000184354.2 NR_105948 uc033hhk.1 uc033hhk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hhk.1 uc033hhk.2 
ENSMUST00000184356.2 Obox8 ENSMUST00000184356.2 Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization. (from UniProt V9GWY9) ENSMUST00000184356.1 Gm5585 OBOX8_MOUSE Obox8 V9GWY9 uc291luf.1 uc291luf.2 Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization. Nucleus Specifically expressed in early embryos. Expressed zygotically with expression starting during major zygotic genome activation (ZGA) and peaking in eight-cell stage embryos. Belongs to the paired homeobox family. Obox subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding uc291luf.1 uc291luf.2 
ENSMUST00000184358.3 Mir7653 ENSMUST00000184358.3 microRNA 7653 (from RefSeq NR_106113.1) ENSMUST00000184358.1 ENSMUST00000184358.2 NR_106113 uc033fym.1 uc033fym.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fym.1 uc033fym.2 
ENSMUST00000184359.2 Gm27164 ENSMUST00000184359.2 Gm27164 (from geneSymbol) AK136218 ENSMUST00000184359.1 uc292fou.1 uc292fou.2 uc292fou.1 uc292fou.2 
ENSMUST00000184373.2 Gm27232 ENSMUST00000184373.2 Gm27232 (from geneSymbol) ENSMUST00000184373.1 uc292irh.1 uc292irh.2 uc292irh.1 uc292irh.2 
ENSMUST00000184374.3 Mir7083 ENSMUST00000184374.3 microRNA 7083 (from RefSeq NR_106051.1) ENSMUST00000184374.1 ENSMUST00000184374.2 NR_106051 uc033jjm.1 uc033jjm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jjm.1 uc033jjm.2 
ENSMUST00000184375.3 Mir8109 ENSMUST00000184375.3 microRNA 8109 (from RefSeq NR_106189.1) ENSMUST00000184375.1 ENSMUST00000184375.2 NR_106189 uc033jgn.1 uc033jgn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jgn.1 uc033jgn.2 
ENSMUST00000184381.3 Mir6974 ENSMUST00000184381.3 microRNA 6974 (from RefSeq NR_105940.1) ENSMUST00000184381.1 ENSMUST00000184381.2 NR_105940 uc033hdh.1 uc033hdh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hdh.1 uc033hdh.2 
ENSMUST00000184382.3 Mir8112 ENSMUST00000184382.3 microRNA 8112 (from RefSeq NR_106192.1) ENSMUST00000184382.1 ENSMUST00000184382.2 NR_106192 uc033ish.1 uc033ish.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ish.1 uc033ish.2 
ENSMUST00000184383.2 Gm27188 ENSMUST00000184383.2 Gm27188 (from geneSymbol) ENSMUST00000184383.1 uc292ipa.1 uc292ipa.2 uc292ipa.1 uc292ipa.2 
ENSMUST00000184384.3 Mir7026 ENSMUST00000184384.3 microRNA 7026 (from RefSeq NR_105993.1) ENSMUST00000184384.1 ENSMUST00000184384.2 NR_105993 uc033ilc.1 uc033ilc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ilc.1 uc033ilc.2 
ENSMUST00000184391.3 Mir6391 ENSMUST00000184391.3 microRNA 6391 (from RefSeq NR_105815.1) ENSMUST00000184391.1 ENSMUST00000184391.2 NR_105815 uc033gss.1 uc033gss.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gss.1 uc033gss.2 
ENSMUST00000184398.3 Mir7008 ENSMUST00000184398.3 microRNA 7008 (from RefSeq NR_105975.1) ENSMUST00000184398.1 ENSMUST00000184398.2 NR_105975 uc033hsv.1 uc033hsv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hsv.1 uc033hsv.2 
ENSMUST00000184404.8 Ism1 ENSMUST00000184404.8 isthmin 1, angiogenesis inhibitor (from RefSeq NM_001276489.2) ENSMUST00000184404.1 ENSMUST00000184404.2 ENSMUST00000184404.3 ENSMUST00000184404.4 ENSMUST00000184404.5 ENSMUST00000184404.6 ENSMUST00000184404.7 Ism1 NM_001276489 V9GXR4 V9GXR4_MOUSE uc008mpf.1 uc008mpf.2 uc008mpf.3 uc008mpf.4 Belongs to the isthmin family. uc008mpf.1 uc008mpf.2 uc008mpf.3 uc008mpf.4 
ENSMUST00000184405.3 Mir6390 ENSMUST00000184405.3 microRNA 6390 (from RefSeq NR_105814.1) ENSMUST00000184405.1 ENSMUST00000184405.2 NR_105814 uc033gsl.1 uc033gsl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gsl.1 uc033gsl.2 
ENSMUST00000184412.3 Mir7067 ENSMUST00000184412.3 microRNA 7067 (from RefSeq NR_106034.1) ENSMUST00000184412.1 ENSMUST00000184412.2 NR_106034 uc033jga.1 uc033jga.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jga.1 uc033jga.2 
ENSMUST00000184414.3 Mir7037 ENSMUST00000184414.3 microRNA 7037 (from RefSeq NR_106004.1) ENSMUST00000184414.1 ENSMUST00000184414.2 NR_106004 uc033inj.1 uc033inj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033inj.1 uc033inj.2 
ENSMUST00000184415.8 Mlip ENSMUST00000184415.8 muscular LMNA-interacting protein, transcript variant 36 (from RefSeq NM_001368989.1) ENSMUST00000184415.1 ENSMUST00000184415.2 ENSMUST00000184415.3 ENSMUST00000184415.4 ENSMUST00000184415.5 ENSMUST00000184415.6 ENSMUST00000184415.7 Mlip NM_001368989 V9GXP3 V9GXP3_MOUSE uc292ixu.1 uc292ixu.2 uc292ixu.1 uc292ixu.2 
ENSMUST00000184417.3 Mir6388 ENSMUST00000184417.3 microRNA 6388 (from RefSeq NR_105810.1) ENSMUST00000184417.1 ENSMUST00000184417.2 NR_105810 uc033ggj.1 uc033ggj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ggj.1 uc033ggj.2 
ENSMUST00000184421.8 Gm3434 ENSMUST00000184421.8 Gm3434 (from geneSymbol) ENSMUST00000184421.1 ENSMUST00000184421.2 ENSMUST00000184421.3 ENSMUST00000184421.4 ENSMUST00000184421.5 ENSMUST00000184421.6 ENSMUST00000184421.7 uc292frx.1 uc292frx.2 uc292frx.1 uc292frx.2 
ENSMUST00000184426.3 Mir7117 ENSMUST00000184426.3 microRNA 7117 (from RefSeq NR_106065.1) ENSMUST00000184426.1 ENSMUST00000184426.2 NR_106065 uc033gtj.1 uc033gtj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gtj.1 uc033gtj.2 
ENSMUST00000184427.3 Mir7j ENSMUST00000184427.3 microRNA 7j (from RefSeq NR_105798.1) ENSMUST00000184427.1 ENSMUST00000184427.2 NR_105798 uc033iad.1 uc033iad.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iad.1 uc033iad.2 
ENSMUST00000184428.6 Efcab12 ENSMUST00000184428.6 EF-hand calcium binding domain 12, transcript variant 3 (from RefSeq NM_001411533.1) ENSMUST00000184428.1 ENSMUST00000184428.2 ENSMUST00000184428.3 ENSMUST00000184428.4 ENSMUST00000184428.5 Efcab12 NM_001411533 V9GXH0 V9GXH0_MOUSE uc012eqq.1 uc012eqq.2 uc012eqq.3 molecular_function calcium ion binding cellular_component biological_process uc012eqq.1 uc012eqq.2 uc012eqq.3 
ENSMUST00000184430.2 Trgj4 ENSMUST00000184430.2 Trgj4 (from geneSymbol) A0A0G2JF87 A0A0G2JF87_MOUSE ENSMUST00000184430.1 M26766 Trgj4 uc288lcb.1 uc288lcb.2 uc288lcb.1 uc288lcb.2 
ENSMUST00000184431.2 Gm27235 ENSMUST00000184431.2 Gm27235 (from geneSymbol) AK136605 ENSMUST00000184431.1 Gm27235 Q3UW50 Q3UW50_MOUSE uc292fro.1 uc292fro.2 uc292fro.1 uc292fro.2 
ENSMUST00000184433.4 Gm55287 ENSMUST00000184433.4 Gm55287 (from geneSymbol) ENSMUST00000184433.1 ENSMUST00000184433.2 ENSMUST00000184433.3 uc033ive.1 uc033ive.2 uc033ive.1 uc033ive.2 
ENSMUST00000184434.3 Mir145b ENSMUST00000184434.3 microRNA 145b (from RefSeq NR_105780.1) ENSMUST00000184434.1 ENSMUST00000184434.2 NR_105780 uc033hhv.1 uc033hhv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hhv.1 uc033hhv.2 
ENSMUST00000184435.3 Mir7236 ENSMUST00000184435.3 microRNA 7236 (from RefSeq NR_106095.1) ENSMUST00000184435.1 ENSMUST00000184435.2 NR_106095 uc033gcc.1 uc033gcc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gcc.1 uc033gcc.2 
ENSMUST00000184437.3 Mir6236 ENSMUST00000184437.3 microRNA 6236 (from RefSeq NR_105744.1) ENSMUST00000184437.1 ENSMUST00000184437.2 NR_105744 uc033jng.1 uc033jng.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jng.1 uc033jng.2 
ENSMUST00000184438.3 Mir6950 ENSMUST00000184438.3 microRNA 6950 (from RefSeq NR_105915.1) ENSMUST00000184438.1 ENSMUST00000184438.2 NR_105915 uc033grt.1 uc033grt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033grt.1 uc033grt.2 
ENSMUST00000184451.8 Rhox3f ENSMUST00000184451.8 Nucleus (from UniProt A2ANE1) A2ANE1 A2ANE1_MOUSE BC145759 ENSMUST00000184451.1 ENSMUST00000184451.2 ENSMUST00000184451.3 ENSMUST00000184451.4 ENSMUST00000184451.5 ENSMUST00000184451.6 ENSMUST00000184451.7 F7BKG6 Rhox3f uc292nue.1 uc292nue.2 Nucleus DNA binding cellular_component nucleus biological_process uc292nue.1 uc292nue.2 
ENSMUST00000184453.3 Mir6978 ENSMUST00000184453.3 microRNA 6978 (from RefSeq NR_105944.1) ENSMUST00000184453.1 ENSMUST00000184453.2 NR_105944 uc033heu.1 uc033heu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033heu.1 uc033heu.2 
ENSMUST00000184456.3 Mir6912 ENSMUST00000184456.3 microRNA 6912 (from RefSeq NR_105877.1) ENSMUST00000184456.1 ENSMUST00000184456.2 NR_105877 uc033fre.1 uc033fre.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fre.1 uc033fre.2 
ENSMUST00000184463.3 Mir8111 ENSMUST00000184463.3 microRNA 8111 (from RefSeq NR_106191.1) ENSMUST00000184463.1 ENSMUST00000184463.2 NR_106191 uc033jgj.1 uc033jgj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jgj.1 uc033jgj.2 
ENSMUST00000184464.3 Mir6942 ENSMUST00000184464.3 microRNA 6942 (from RefSeq NR_105907.1) ENSMUST00000184464.1 ENSMUST00000184464.2 NR_105907 uc033ghr.1 uc033ghr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ghr.1 uc033ghr.2 
ENSMUST00000184470.3 Mir6371 ENSMUST00000184470.3 microRNA 6371 (from RefSeq NR_105790.1) ENSMUST00000184470.1 ENSMUST00000184470.2 NR_105790 uc057adc.1 uc057adc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057adc.1 uc057adc.2 
ENSMUST00000184472.3 Mir6366 ENSMUST00000184472.3 microRNA 6366 (from RefSeq NR_105785.1) ENSMUST00000184472.1 ENSMUST00000184472.2 NR_105785 uc033gyf.1 uc033gyf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gyf.1 uc033gyf.2 
ENSMUST00000184476.2 Gm27166 ENSMUST00000184476.2 Gm27166 (from geneSymbol) AK081663 ENSMUST00000184476.1 uc292foj.1 uc292foj.2 uc292foj.1 uc292foj.2 
ENSMUST00000184477.3 Mir6412 ENSMUST00000184477.3 microRNA 6412 (from RefSeq NR_105839.1) ENSMUST00000184477.1 ENSMUST00000184477.2 NR_105839 uc056yit.1 uc056yit.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yit.1 uc056yit.2 
ENSMUST00000184478.3 Mir378c ENSMUST00000184478.3 microRNA 378c (from RefSeq NR_105813.1) ENSMUST00000184478.1 ENSMUST00000184478.2 NR_105813 uc056ywi.1 uc056ywi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056ywi.1 uc056ywi.2 
ENSMUST00000184480.8 Myo6 ENSMUST00000184480.8 myosin VI, transcript variant 1 (from RefSeq NM_001408252.1) ENSMUST00000184480.1 ENSMUST00000184480.2 ENSMUST00000184480.3 ENSMUST00000184480.4 ENSMUST00000184480.5 ENSMUST00000184480.6 ENSMUST00000184480.7 Myo6 NM_001408252 V9GX76 V9GX76_MOUSE uc292jdf.1 uc292jdf.2 Cell projection, filopodium Cell projection, microvillus Cell projection, ruffle membrane Cytoplasmic vesicle, clathrin-coated vesicle Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Membrane, clathrin-coated pit Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. nucleotide binding motor activity actin binding ATP binding myosin complex actin filament binding uc292jdf.1 uc292jdf.2 
ENSMUST00000184483.3 Mir6986 ENSMUST00000184483.3 microRNA 6986 (from RefSeq NR_105952.1) ENSMUST00000184483.1 ENSMUST00000184483.2 NR_105952 uc033hij.1 uc033hij.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hij.1 uc033hij.2 
ENSMUST00000184488.2 Gm19541 ENSMUST00000184488.2 Gm19541 (from geneSymbol) AK142571 ENSMUST00000184488.1 uc009qtf.1 uc009qtf.2 uc009qtf.3 uc009qtf.1 uc009qtf.2 uc009qtf.3 
ENSMUST00000184489.3 Mir130c ENSMUST00000184489.3 microRNA 130c (from RefSeq NR_105807.1) ENSMUST00000184489.1 ENSMUST00000184489.2 NR_105807 uc033jkn.1 uc033jkn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jkn.1 uc033jkn.2 
ENSMUST00000184490.3 Mir7081 ENSMUST00000184490.3 microRNA 7081 (from RefSeq NR_106049.1) ENSMUST00000184490.1 ENSMUST00000184490.2 NR_106049 uc033jje.1 uc033jje.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jje.1 uc033jje.2 
ENSMUST00000184492.2 Gm27153 ENSMUST00000184492.2 Gm27153 (from geneSymbol) ENSMUST00000184492.1 uc288ykv.1 uc288ykv.2 uc288ykv.1 uc288ykv.2 
ENSMUST00000184494.3 Mir6927 ENSMUST00000184494.3 microRNA 6927 (from RefSeq NR_105892.1) ENSMUST00000184494.1 ENSMUST00000184494.2 NR_105892 uc033fzr.1 uc033fzr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fzr.1 uc033fzr.2 
ENSMUST00000184495.3 Mir6352 ENSMUST00000184495.3 microRNA 6352 (from RefSeq NR_105770.1) ENSMUST00000184495.1 ENSMUST00000184495.2 NR_105770 uc033fjr.1 uc033fjr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fjr.1 uc033fjr.2 
ENSMUST00000184499.3 Mir6401 ENSMUST00000184499.3 microRNA 6401 (from RefSeq NR_105827.1) ENSMUST00000184499.1 ENSMUST00000184499.2 NR_105827 uc033jcs.1 uc033jcs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jcs.1 uc033jcs.2 
ENSMUST00000184502.8 H2-T13 ENSMUST00000184502.8 Involved in the presentation of foreign antigens to the immune system. (from UniProt V9GXR0) AY989826 ENSMUST00000184502.1 ENSMUST00000184502.2 ENSMUST00000184502.3 ENSMUST00000184502.4 ENSMUST00000184502.5 ENSMUST00000184502.6 ENSMUST00000184502.7 H2-Bl V9GXR0 V9GXR0_MOUSE uc012ase.1 uc012ase.2 uc012ase.3 Involved in the presentation of foreign antigens to the immune system. Membrane ; Single- pass type I membrane protein Belongs to the MHC class I family. positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent receptor binding extracellular space plasma membrane immune response external side of plasma membrane membrane integral component of membrane peptide antigen binding uc012ase.1 uc012ase.2 uc012ase.3 
ENSMUST00000184508.3 Mir7219 ENSMUST00000184508.3 microRNA 7219 (from RefSeq NR_106078.1) ENSMUST00000184508.1 ENSMUST00000184508.2 NR_106078 uc033hhq.1 uc033hhq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hhq.1 uc033hhq.2 
ENSMUST00000184510.3 Mir6407 ENSMUST00000184510.3 microRNA 6407 (from RefSeq NR_105834.1) ENSMUST00000184510.1 ENSMUST00000184510.2 NR_105834 uc033hkw.1 uc033hkw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hkw.1 uc033hkw.2 
ENSMUST00000184514.3 Mir6916 ENSMUST00000184514.3 microRNA 6916 (from RefSeq NR_105881.1) ENSMUST00000184514.1 ENSMUST00000184514.2 NR_105881 uc033fth.1 uc033fth.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fth.1 uc033fth.2 
ENSMUST00000184517.8 Zfp280d ENSMUST00000184517.8 May function as a transcription factor. (from UniProt Q68FE8) AK045173 ENSMUST00000184517.1 ENSMUST00000184517.2 ENSMUST00000184517.3 ENSMUST00000184517.4 ENSMUST00000184517.5 ENSMUST00000184517.6 ENSMUST00000184517.7 Q3T9B1 Q68FE8 Q8BI82 Suhw4 Z280D_MOUSE Znf280d uc009qpo.1 uc009qpo.2 uc009qpo.3 uc009qpo.4 May function as a transcription factor. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q68FE8-1; Sequence=Displayed; Name=2; IsoId=Q68FE8-2; Sequence=VSP_017630, VSP_017633; Name=3; IsoId=Q68FE8-3; Sequence=VSP_017629, VSP_017631, VSP_017632; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009qpo.1 uc009qpo.2 uc009qpo.3 uc009qpo.4 
ENSMUST00000184519.3 Mir7009 ENSMUST00000184519.3 microRNA 7009 (from RefSeq NR_105976.1) ENSMUST00000184519.1 ENSMUST00000184519.2 NR_105976 uc033hsz.1 uc033hsz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hsz.1 uc033hsz.2 
ENSMUST00000184520.3 Mir8106 ENSMUST00000184520.3 microRNA 8106 (from RefSeq NR_106185.1) ENSMUST00000184520.1 ENSMUST00000184520.2 NR_106185 uc033jnx.1 uc033jnx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jnx.1 uc033jnx.2 
ENSMUST00000184522.3 Mir7089 ENSMUST00000184522.3 microRNA 7089 (from RefSeq NR_106057.1) ENSMUST00000184522.1 ENSMUST00000184522.2 NR_106057 uc033jnf.1 uc033jnf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jnf.1 uc033jnf.2 
ENSMUST00000184524.3 Mir7002 ENSMUST00000184524.3 microRNA 7002 (from RefSeq NR_105968.1) ENSMUST00000184524.1 ENSMUST00000184524.2 NR_105968 uc033hpi.1 uc033hpi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hpi.1 uc033hpi.2 
ENSMUST00000184526.3 Mir8096 ENSMUST00000184526.3 microRNA 8096 (from RefSeq NR_106172.1) ENSMUST00000184526.1 ENSMUST00000184526.2 NR_106172 uc033fkb.1 uc033fkb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fkb.1 uc033fkb.2 
ENSMUST00000184530.4 1500015A07Rik ENSMUST00000184530.4 1500015A07Rik (from geneSymbol) ENSMUST00000184530.1 ENSMUST00000184530.2 ENSMUST00000184530.3 uc289php.1 uc289php.2 uc289php.3 uc289php.4 uc289php.1 uc289php.2 uc289php.3 uc289php.4 
ENSMUST00000184532.3 Mir7241 ENSMUST00000184532.3 microRNA 7241 (from RefSeq NR_106100.1) ENSMUST00000184532.1 ENSMUST00000184532.2 NR_106100 uc029xdb.1 uc029xdb.2 uc029xdb.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029xdb.1 uc029xdb.2 uc029xdb.3 
ENSMUST00000184541.3 Mir6398 ENSMUST00000184541.3 microRNA 6398 (from RefSeq NR_105824.1) ENSMUST00000184541.1 ENSMUST00000184541.2 NR_105824 uc033ieh.1 uc033ieh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ieh.1 uc033ieh.2 
ENSMUST00000184542.3 Mir7072 ENSMUST00000184542.3 microRNA 7072 (from RefSeq NR_106040.1) ENSMUST00000184542.1 ENSMUST00000184542.2 NR_106040 uc033jgv.1 uc033jgv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jgv.1 uc033jgv.2 
ENSMUST00000184545.3 Mir6383 ENSMUST00000184545.3 microRNA 6383 (from RefSeq NR_105804.1) ENSMUST00000184545.1 ENSMUST00000184545.2 NR_105804 uc033jth.1 uc033jth.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jth.1 uc033jth.2 
ENSMUST00000184547.3 Gm27616 ENSMUST00000184547.3 Gm27616 (from geneSymbol) ENSMUST00000184547.1 ENSMUST00000184547.2 uc287nga.1 uc287nga.2 uc287nga.1 uc287nga.2 
ENSMUST00000184549.3 Mir6358 ENSMUST00000184549.3 microRNA 6358 (from RefSeq NR_105776.1) ENSMUST00000184549.1 ENSMUST00000184549.2 NR_105776 uc033hia.1 uc033hia.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hia.1 uc033hia.2 
ENSMUST00000184553.3 Mir7064 ENSMUST00000184553.3 microRNA 7064 (from RefSeq NR_106031.1) ENSMUST00000184553.1 ENSMUST00000184553.2 NR_106031 uc033jdl.1 uc033jdl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jdl.1 uc033jdl.2 
ENSMUST00000184562.3 Mir6926 ENSMUST00000184562.3 microRNA 6926 (from RefSeq NR_105891.1) ENSMUST00000184562.1 ENSMUST00000184562.2 NR_105891 uc033fye.1 uc033fye.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fye.1 uc033fye.2 
ENSMUST00000184565.8 Rhox3a2 ENSMUST00000184565.8 Nucleus (from UniProt Q4TU90) E9Q4C8 ENSMUST00000184565.1 ENSMUST00000184565.2 ENSMUST00000184565.3 ENSMUST00000184565.4 ENSMUST00000184565.5 ENSMUST00000184565.6 ENSMUST00000184565.7 F6PYZ5 Q4TU90 Q4TU90_MOUSE Rhox3a Rhox3a2 Rhox3e uc292nti.1 uc292nti.2 Nucleus negative regulation of transcription from RNA polymerase II promoter molecular_function DNA binding cellular_component nucleus biological_process uc292nti.1 uc292nti.2 
ENSMUST00000184567.3 Mir7673 ENSMUST00000184567.3 microRNA 7673 (from RefSeq NR_106133.1) ENSMUST00000184567.1 ENSMUST00000184567.2 NR_106133 uc033jrj.1 uc033jrj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jrj.1 uc033jrj.2 
ENSMUST00000184570.4 Gm27449 ENSMUST00000184570.4 Gm27449 (from geneSymbol) ENSMUST00000184570.1 ENSMUST00000184570.2 ENSMUST00000184570.3 uc290atr.1 uc290atr.2 uc290atr.1 uc290atr.2 
ENSMUST00000184572.8 Aspa ENSMUST00000184572.8 Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids. (from UniProt Q8R3P0) ACY2_MOUSE AK002859 Aspa ENSMUST00000184572.1 ENSMUST00000184572.2 ENSMUST00000184572.3 ENSMUST00000184572.4 ENSMUST00000184572.5 ENSMUST00000184572.6 ENSMUST00000184572.7 Q5SV07 Q8R3P0 Q9D876 Q9DCE2 Q9JIN8 uc287zyx.1 uc287zyx.2 Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids. Reaction=H2O + N-acyl-L-aspartate = a carboxylate + L-aspartate; Xref=Rhea:RHEA:10872, ChEBI:CHEBI:15377, ChEBI:CHEBI:29067, ChEBI:CHEBI:29991, ChEBI:CHEBI:58497; EC=3.5.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10873; Evidence=; Reaction=H2O + N-acetyl-L-aspartate = acetate + L-aspartate; Xref=Rhea:RHEA:59408, ChEBI:CHEBI:15377, ChEBI:CHEBI:16953, ChEBI:CHEBI:29991, ChEBI:CHEBI:30089; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59409; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Homodimer. Cytoplasm Nucleus Belongs to the AspA/AstE family. Aspartoacylase subfamily. aminoacylase activity protein binding nucleus cytoplasm cytosol acetate metabolic process hydrolase activity hydrolase activity, acting on ester bonds hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides aspartoacylase activity central nervous system myelination identical protein binding metal ion binding positive regulation of oligodendrocyte differentiation uc287zyx.1 uc287zyx.2 
ENSMUST00000184581.3 Clec7a ENSMUST00000184581.3 C-type lectin domain family 7, member a, transcript variant 2 (from RefSeq NM_001309637.2) Clec7a ENSMUST00000184581.1 ENSMUST00000184581.2 NM_001309637 V9GXI5 V9GXI5_MOUSE uc057byg.1 uc057byg.2 uc057byg.3 membrane integral component of membrane carbohydrate binding uc057byg.1 uc057byg.2 uc057byg.3 
ENSMUST00000184584.3 Mir6405 ENSMUST00000184584.3 microRNA 6405 (from RefSeq NR_105831.1) ENSMUST00000184584.1 ENSMUST00000184584.2 NR_105831 uc033hkr.1 uc033hkr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hkr.1 uc033hkr.2 
ENSMUST00000184587.5 Chaserr ENSMUST00000184587.5 CHD2 adjacent suppressive regulatory RNA (from RefSeq NR_037569.1) ENSMUST00000184587.1 ENSMUST00000184587.2 ENSMUST00000184587.3 ENSMUST00000184587.4 NR_037569 uc291rkp.1 uc291rkp.2 uc291rkp.1 uc291rkp.2 
ENSMUST00000184592.3 Mir6923 ENSMUST00000184592.3 microRNA 6923 (from RefSeq NR_105888.1) ENSMUST00000184592.1 ENSMUST00000184592.2 NR_105888 uc033fwk.1 uc033fwk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fwk.1 uc033fwk.2 
ENSMUST00000184595.3 Mir7047 ENSMUST00000184595.3 microRNA 7047 (from RefSeq NR_106014.1) ENSMUST00000184595.1 ENSMUST00000184595.2 NR_106014 uc033ixo.1 uc033ixo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ixo.1 uc033ixo.2 
ENSMUST00000184597.3 Mir7044 ENSMUST00000184597.3 microRNA 7044 (from RefSeq NR_106011.1) ENSMUST00000184597.1 ENSMUST00000184597.2 NR_106011 uc033iui.1 uc033iui.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iui.1 uc033iui.2 
ENSMUST00000184599.3 Mir7671 ENSMUST00000184599.3 microRNA 7671 (from RefSeq NR_106131.1) ENSMUST00000184599.1 ENSMUST00000184599.2 NR_106131 uc033fvn.1 uc033fvn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fvn.1 uc033fvn.2 
ENSMUST00000184603.8 Gm28040 ENSMUST00000184603.8 May be involved in fusion of ER-derived transport vesicles with the Golgi complex. (from UniProt A0A5C8) A0A5C8 A0A5C8_MOUSE AY707860 ENSMUST00000184603.1 ENSMUST00000184603.2 ENSMUST00000184603.3 ENSMUST00000184603.4 ENSMUST00000184603.5 ENSMUST00000184603.6 ENSMUST00000184603.7 Gm28040 Kiss1 uc007cqb.1 uc007cqb.2 uc007cqb.3 May be involved in fusion of ER-derived transport vesicles with the Golgi complex. Membrane ; Multi- pass membrane protein Belongs to the GOT1 family. membrane integral component of membrane vesicle-mediated transport uc007cqb.1 uc007cqb.2 uc007cqb.3 
ENSMUST00000184606.3 Mir7007 ENSMUST00000184606.3 microRNA 7007 (from RefSeq NR_105974.1) ENSMUST00000184606.1 ENSMUST00000184606.2 NR_105974 uc033hsl.1 uc033hsl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hsl.1 uc033hsl.2 
ENSMUST00000184607.3 Mir7003 ENSMUST00000184607.3 microRNA 7003 (from RefSeq NR_105970.1) ENSMUST00000184607.1 ENSMUST00000184607.2 NR_105970 uc033hrd.1 uc033hrd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hrd.1 uc033hrd.2 
ENSMUST00000184608.3 Mir1957b ENSMUST00000184608.3 Mir1957b (from geneSymbol) ENSMUST00000184608.1 ENSMUST00000184608.2 uc033jhw.1 uc033jhw.2 uc033jhw.1 uc033jhw.2 
ENSMUST00000184616.8 Atf7 ENSMUST00000184616.8 activating transcription factor 7, transcript variant 2 (from RefSeq NM_001310067.1) Atf7 ENSMUST00000184616.1 ENSMUST00000184616.2 ENSMUST00000184616.3 ENSMUST00000184616.4 ENSMUST00000184616.5 ENSMUST00000184616.6 ENSMUST00000184616.7 NM_001310067 Q3TZR9 Q3TZR9_MOUSE uc007xwn.1 uc007xwn.2 uc007xwn.3 uc007xwn.4 Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di- methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening. Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members. Nucleus Belongs to the bZIP family. nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated uc007xwn.1 uc007xwn.2 uc007xwn.3 uc007xwn.4 
ENSMUST00000184617.3 Mir6481 ENSMUST00000184617.3 microRNA 6481 (from RefSeq NR_105852.1) ENSMUST00000184617.1 ENSMUST00000184617.2 NR_105852 uc033hyr.1 uc033hyr.2 uc033hyr.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hyr.1 uc033hyr.2 uc033hyr.3 
ENSMUST00000184622.3 Mir7094-2 ENSMUST00000184622.3 microRNA 7094-2 (from RefSeq NR_106063.1) ENSMUST00000184622.1 ENSMUST00000184622.2 NR_106063 uc033ggi.1 uc033ggi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ggi.1 uc033ggi.2 
ENSMUST00000184626.3 Gm27200 ENSMUST00000184626.3 Gm27200 (from geneSymbol) ENSMUST00000184626.1 ENSMUST00000184626.2 uc290skv.1 uc290skv.2 uc290skv.3 uc290skv.1 uc290skv.2 uc290skv.3 
ENSMUST00000184632.3 Mir7048 ENSMUST00000184632.3 microRNA 7048 (from RefSeq NR_106015.1) ENSMUST00000184632.1 ENSMUST00000184632.2 NR_106015 uc033ixq.1 uc033ixq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ixq.1 uc033ixq.2 
ENSMUST00000184635.8 Hnrnpll ENSMUST00000184635.8 heterogeneous nuclear ribonucleoprotein L-like, transcript variant 1 (from RefSeq NM_144802.4) ENSMUST00000184635.1 ENSMUST00000184635.2 ENSMUST00000184635.3 ENSMUST00000184635.4 ENSMUST00000184635.5 ENSMUST00000184635.6 ENSMUST00000184635.7 HNRLL_MOUSE Hnrpll NM_144802 Q3UIK6 Q6IR44 Q8BIP6 Q91W02 Q921F4 Q99J40 uc008dqk.1 uc008dqk.2 uc008dqk.3 uc008dqk.4 RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. Interacts with HNRNPL. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q921F4-1; Sequence=Displayed; Name=2; IsoId=Q921F4-4; Sequence=VSP_013290, VSP_013291; Name=3; IsoId=Q921F4-5; Sequence=VSP_026132, VSP_026133; Up-regulated in stimulated T-cells. Sequence=BAE27500.1; Type=Erroneous initiation; Evidence=; nucleic acid binding RNA binding mRNA binding nucleus mRNA processing positive regulation of RNA splicing uc008dqk.1 uc008dqk.2 uc008dqk.3 uc008dqk.4 
ENSMUST00000184636.3 Mir7050 ENSMUST00000184636.3 microRNA 7050 (from RefSeq NR_106017.1) ENSMUST00000184636.1 ENSMUST00000184636.2 NR_106017 uc033iym.1 uc033iym.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iym.1 uc033iym.2 
ENSMUST00000184637.3 Mir7058 ENSMUST00000184637.3 microRNA 7058 (from RefSeq NR_106025.1) ENSMUST00000184637.1 ENSMUST00000184637.2 NR_106025 uc033jca.1 uc033jca.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jca.1 uc033jca.2 
ENSMUST00000184638.3 Gm27239 ENSMUST00000184638.3 predicted gene 27239 (from RefSeq NR_169072.1) ENSMUST00000184638.1 ENSMUST00000184638.2 NR_169072 uc289puh.1 uc289puh.2 uc289puh.3 uc289puh.1 uc289puh.2 uc289puh.3 
ENSMUST00000184641.3 Mir6985 ENSMUST00000184641.3 microRNA 6985 (from RefSeq NR_105951.1) ENSMUST00000184641.1 ENSMUST00000184641.2 NR_105951 uc033hii.1 uc033hii.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hii.1 uc033hii.2 
ENSMUST00000184645.3 4932415M13Rik ENSMUST00000184645.3 RIKEN cDNA 4932415M13 gene (from RefSeq NR_073205.1) ENSMUST00000184645.1 ENSMUST00000184645.2 NR_073205 uc033hen.1 uc033hen.2 uc033hen.3 uc033hen.1 uc033hen.2 uc033hen.3 
ENSMUST00000184647.2 C1rb ENSMUST00000184647.2 complement component 1, r subcomponent B (from RefSeq NM_001113356.1) C1RB_MOUSE C1r ENSMUST00000184647.1 NM_001113356 Q8CFG9 uc009drd.1 uc009drd.2 uc009drd.3 C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Reaction=Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).; EC=3.4.21.41; C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds (By similarity). Specifically expressed in male reproductive tissues. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Belongs to the peptidase S1 family. immune system process serine-type endopeptidase activity calcium ion binding extracellular space proteolysis complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity zymogen activation innate immune response uc009drd.1 uc009drd.2 uc009drd.3 
ENSMUST00000184652.2 Gm27179 ENSMUST00000184652.2 predicted gene 27179 (from RefSeq NM_001388491.1) ENSMUST00000184652.1 NM_001388491 Q8BI41 SYNB_MOUSE Synb V9GXQ5 uc007umg.1 uc007umg.2 uc007umg.3 This endogenous retroviral envelope protein has retained its original fusogenic properties (PubMed:15644441, PubMed:18077339, PubMed:22032925, PubMed:27589388). Together with Syna, participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis (PubMed:22032925). Synb is specifically involved in formation of syncytiotrophoblast layer II (SynT-II) (PubMed:22032925). Promotes myoblast fusion, and may play a role in regeneration of damaged muscle tissue in males (PubMed:27589388). May have immunosuppressive activity (PubMed:18077339). The mature protein consists of a trimer of SU-TM heterodimers (Probable). The SU-TM heterodimers are attached by a labile interchain disulfide bond (By similarity). [Surface protein]: Cell membrane ; Peripheral membrane protein Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. [Transmembrane protein]: Cell membrane ; Single-pass membrane protein Highly expressed in placenta where it localizes to syncytiotrophoblasts of the labyrinthine zona (PubMed:15644441). Specifically localizes to syncytiotrophoblast layer II (SynT-II) (PubMed:18448564). Also detected at very low levels in ovary (PubMed:15644441). Expressed in the placental labyrinth from stage 8.5 dpc onwards. In males, up-regulated in regenerating muscle tissue after injury. Synthesized as an inactive precursor that is heavily N- glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion. Viable, although growth is retarded and neonate numbers are reduced (PubMed:22032925). In the placental labyrinth, formation of syncytiotrophoblast layer II (SynT-II) is abnormal with reduced cell fusion and progressive expansion of maternal blood lacunae(PubMed:22032925). Unfused SynT-II cells form dense plaque-like structures between adjacent cells, which resemble cell junctions and are associated with high expression levels of GJB6/connexin-30 (PubMed:22032925). Formation of syncytiotrophoblast layer I (SynT-I) is grossly normal (PubMed:22032925). Adult male mice have a 15% reduction in muscle mass compared to wild type, probably due to defects in myoblast fusion (PubMed:27589388). Double knockouts of Syna and Synb are embryonic lethal at stage 9.5 dpc to 10.5 dpc, indicating a more severe phenotype than the Syna single knockout (PubMed:22032925). The mouse genome contains a high percentage of proviral- like elements, also called endogenous retroviruses (ERVs) that are the genomic traces of ancient infections of the germline by exogenous retroviruses. Although most of these elements are defective, some have conserved a functional envelope (env) gene, most probably diverted by the host for its benefit. Belongs to the gamma type-C retroviral envelope protein family. syncytium formation by plasma membrane fusion molecular_function cellular_component plasma membrane syncytium formation multicellular organism development membrane integral component of membrane labyrinthine layer blood vessel development uc007umg.1 uc007umg.2 uc007umg.3 
ENSMUST00000184658.2 Gm19569 ENSMUST00000184658.2 Gm19569 (from geneSymbol) ENSMUST00000184658.1 uc292iyn.1 uc292iyn.2 uc292iyn.1 uc292iyn.2 
ENSMUST00000184661.3 Mir7040 ENSMUST00000184661.3 microRNA 7040 (from RefSeq NR_106007.1) ENSMUST00000184661.1 ENSMUST00000184661.2 NR_106007 uc033isp.1 uc033isp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033isp.1 uc033isp.2 
ENSMUST00000184666.8 Unc13c ENSMUST00000184666.8 unc-13 homolog C (from RefSeq NM_001081153.2) ENSMUST00000184666.1 ENSMUST00000184666.2 ENSMUST00000184666.3 ENSMUST00000184666.4 ENSMUST00000184666.5 ENSMUST00000184666.6 ENSMUST00000184666.7 NM_001081153 Q8K0T7 UN13C_MOUSE uc033jll.1 uc033jll.2 uc033jll.3 uc033jll.4 May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with STX1A and/or STX1B1, VAMP2 and SNAP25. Cytoplasm Membrane ; Peripheral membrane protein Presynaptic cell membrane ; Peripheral membrane protein Note=Localized to presynaptic structures. Restricted to cerebellum, predominantly in the granule cell layer. Almost exclusively present in the molecular layer in which the parallel fiber axons of granule cells terminate on dendrites of Purkinje neurons (at protein level). The C2 domains are not involved in calcium-dependent phospholipid binding. Mutant mice showed no obvious physical or behavioral abnormalities. Some deficiency in motor learning can be observed, compared to wild type, in a motor performance and learning test on a rotating rod, but only at high rotation speed. Belongs to the unc-13 family. Sequence=AAH30416.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N- terminal and C-terminal parts.; Evidence=; non-kinase phorbol ester receptor activity calcium ion binding calmodulin binding phospholipid binding cytoplasm plasma membrane exocytosis chemical synaptic transmission neuromuscular junction development membrane synaptic vesicle exocytosis synaptic vesicle docking synaptic vesicle priming synaptic vesicle maturation syntaxin-1 binding syntaxin binding diacylglycerol binding cell junction synaptic vesicle membrane neuromuscular junction negative regulation of synaptic plasticity synaptic transmission, glutamatergic intracellular signal transduction presynaptic membrane terminal bouton calyx of Held synapse metal ion binding presynaptic active zone dense core granule priming presynapse presynaptic active zone cytoplasmic component presynaptic dense core vesicle exocytosis uc033jll.1 uc033jll.2 uc033jll.3 uc033jll.4 
ENSMUST00000184673.3 Gm27204 ENSMUST00000184673.3 predicted gene 27204 (from RefSeq NR_166646.1) ENSMUST00000184673.1 ENSMUST00000184673.2 NR_166646 uc292irv.1 uc292irv.2 uc292irv.3 uc292irv.1 uc292irv.2 uc292irv.3 
ENSMUST00000184681.3 Mir7664 ENSMUST00000184681.3 microRNA 7664 (from RefSeq NR_106124.1) ENSMUST00000184681.1 ENSMUST00000184681.2 NR_106124 uc056zlf.1 uc056zlf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zlf.1 uc056zlf.2 
ENSMUST00000184682.3 Mir7034 ENSMUST00000184682.3 microRNA 7034 (from RefSeq NR_106001.1) ENSMUST00000184682.1 ENSMUST00000184682.2 NR_106001 uc033imt.1 uc033imt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033imt.1 uc033imt.2 
ENSMUST00000184685.3 Mir7057 ENSMUST00000184685.3 microRNA 7057 (from RefSeq NR_106024.1) ENSMUST00000184685.1 ENSMUST00000184685.2 NR_106024 uc033jaa.1 uc033jaa.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jaa.1 uc033jaa.2 
ENSMUST00000184696.3 Mir7066 ENSMUST00000184696.3 microRNA 7066 (from RefSeq NR_106033.1) ENSMUST00000184696.1 ENSMUST00000184696.2 NR_106033 uc033jfx.1 uc033jfx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jfx.1 uc033jfx.2 
ENSMUST00000184697.3 Mir7079 ENSMUST00000184697.3 microRNA 7079 (from RefSeq NR_106047.1) ENSMUST00000184697.1 ENSMUST00000184697.2 NR_106047 uc033jik.1 uc033jik.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jik.1 uc033jik.2 
ENSMUST00000184699.3 Mir7237 ENSMUST00000184699.3 microRNA 7237 (from RefSeq NR_106096.1) ENSMUST00000184699.1 ENSMUST00000184699.2 NR_106096 uc033jii.1 uc033jii.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jii.1 uc033jii.2 
ENSMUST00000184701.3 Mir6949 ENSMUST00000184701.3 microRNA 6949 (from RefSeq NR_105914.1) ENSMUST00000184701.1 ENSMUST00000184701.2 NR_105914 uc033grc.1 uc033grc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033grc.1 uc033grc.2 
ENSMUST00000184703.8 Dusp13b ENSMUST00000184703.8 dual specificity phosphatase 13B, transcript variant 5 (from RefSeq NM_001374078.1) DS13B_MOUSE Dusp13 Dusp13b ENSMUST00000184703.1 ENSMUST00000184703.2 ENSMUST00000184703.3 ENSMUST00000184703.4 ENSMUST00000184703.5 ENSMUST00000184703.6 ENSMUST00000184703.7 Gm1203 NM_001374078 Q497R2 Q9QYJ7 Tmdp uc288rkj.1 uc288rkj.2 Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In humans, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]. Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro (By similarity). Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro (PubMed:10585869). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=; Most abundantly expressed in the testis. Not detectable in testis in the first 3 weeks of life. The expression markedly increases at approximately the 3rd week after birth and continues to increase gradually into adulthood. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity cytoplasm protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc288rkj.1 uc288rkj.2 
ENSMUST00000184710.3 Mir3620 ENSMUST00000184710.3 microRNA 3620 (from RefSeq NR_106147.1) ENSMUST00000184710.1 ENSMUST00000184710.2 NR_106147 uc033jur.1 uc033jur.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jur.1 uc033jur.2 
ENSMUST00000184711.3 Mir6941 ENSMUST00000184711.3 microRNA 6941 (from RefSeq NR_105906.1) ENSMUST00000184711.1 ENSMUST00000184711.2 NR_105906 uc033gfw.1 uc033gfw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gfw.1 uc033gfw.2 
ENSMUST00000184713.3 Mir7035 ENSMUST00000184713.3 microRNA 7035 (from RefSeq NR_106002.1) ENSMUST00000184713.1 ENSMUST00000184713.2 NR_106002 uc029vph.1 uc029vph.2 uc029vph.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029vph.1 uc029vph.2 uc029vph.3 
ENSMUST00000184718.3 Mir8105 ENSMUST00000184718.3 microRNA 8105 (from RefSeq NR_106183.1) ENSMUST00000184718.1 ENSMUST00000184718.2 NR_106183 uc033ftg.1 uc033ftg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ftg.1 uc033ftg.2 
ENSMUST00000184722.3 Mir7687 ENSMUST00000184722.3 microRNA 7687 (from RefSeq NR_106159.1) ENSMUST00000184722.1 ENSMUST00000184722.2 NR_106159 uc033jie.1 uc033jie.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jie.1 uc033jie.2 
ENSMUST00000184730.8 Wnk3 ENSMUST00000184730.8 WNK lysine deficient protein kinase 3, transcript variant 2 (from RefSeq NM_001271679.1) ENSMUST00000184730.1 ENSMUST00000184730.2 ENSMUST00000184730.3 ENSMUST00000184730.4 ENSMUST00000184730.5 ENSMUST00000184730.6 ENSMUST00000184730.7 H6WJI2 H6WJI3 NM_001271679 Q80XP9 WNK3_MOUSE Wnk3 uc009upa.1 uc009upa.2 uc009upa.3 uc009upa.4 uc009upa.5 Serine/threonine-protein kinase component of the WNK3- SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (By similarity). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid- liquid phase separation (By similarity). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:19470686). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (By similarity). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (By similarity). May also phosphorylate NEDD4L (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (By similarity). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated in response to hyperosmotic stress: cell shrinkage promotes formation of a membraneless compartment that concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK (By similarity). Activation requires autophosphorylation of Ser-307 and, to a lower extent, Ser-303 (By similarity). Autophosphorylation and subsequent activation is inhibited by increases in intracellular ionic strength: Cl(-) potently inhibits WNK3 kinase activity via direct binding (By similarity). Also inhibited by K(+) ions. Kinase activity is inhibited by WNK4 (By similarity). Interacts with WNK1 and WNK4. Cytoplasm Note=Mediates formation and localizes to cytoplasmic membraneless compartment in response to hyperosmotic stress. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80XP9-1; Sequence=Displayed; Name=2; IsoId=Q80XP9-2; Sequence=VSP_041934; Expressed in pancreatic duct (PubMed:21317537). Disordered regions undergo liquid-liquid phase separation (LLPS) for the formation of a cytoplasmic membraneless compartment that concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK. Autophosphorylated at Ser-303 and Ser-307, promoting its activity (By similarity). Phosphorylation at Thr-540 prevents interaction with KLHL3 and subsequent ubiquitination and degradation by the BCR(KLHL3) complex (By similarity). Ubiquitinated by the BCR(KLHL2) complex, leading to its degradation. Ubiquitinated by the BCR(KLHL3) complex, leading to its degradation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm cytosol adherens junction bicellular tight junction protein phosphorylation positive regulation of sodium ion transport negative regulation of sodium ion transport positive regulation of peptidyl-threonine phosphorylation kinase activity phosphorylation transferase activity chloride channel inhibitor activity potassium channel inhibitor activity positive regulation of ion transmembrane transporter activity intracellular signal transduction negative regulation of apoptotic process protein autophosphorylation ion homeostasis positive regulation of calcium ion transport protein localization to plasma membrane negative regulation of pancreatic juice secretion regulation of calcium ion import positive regulation of protein localization to plasma membrane positive regulation of potassium ion import positive regulation of sodium ion transmembrane transporter activity uc009upa.1 uc009upa.2 uc009upa.3 uc009upa.4 uc009upa.5 
ENSMUST00000184733.3 Mir6965 ENSMUST00000184733.3 microRNA 6965 (from RefSeq NR_105930.1) ENSMUST00000184733.1 ENSMUST00000184733.2 NR_105930 uc033hbp.1 uc033hbp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hbp.1 uc033hbp.2 
ENSMUST00000184738.3 Mir6394 ENSMUST00000184738.3 microRNA 6394 (from RefSeq NR_105818.1) ENSMUST00000184738.1 ENSMUST00000184738.2 NR_105818 uc033jah.1 uc033jah.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jah.1 uc033jah.2 
ENSMUST00000184739.3 Mir6968 ENSMUST00000184739.3 microRNA 6968 (from RefSeq NR_105934.1) ENSMUST00000184739.1 ENSMUST00000184739.2 NR_105934 uc033hce.1 uc033hce.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hce.1 uc033hce.2 
ENSMUST00000184744.2 Kctd12 ENSMUST00000184744.2 potassium channel tetramerisation domain containing 12 (from RefSeq NM_177715.4) A0A0R4J2B2 A0A0R4J2B2_MOUSE ENSMUST00000184744.1 Kctd12 NM_177715 uc007uwe.1 uc007uwe.2 identical protein binding protein homooligomerization uc007uwe.1 uc007uwe.2 
ENSMUST00000184745.3 Mir6953 ENSMUST00000184745.3 microRNA 6953 (from RefSeq NR_105918.1) ENSMUST00000184745.1 ENSMUST00000184745.2 NR_105918 uc033guq.1 uc033guq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033guq.1 uc033guq.2 
ENSMUST00000184749.3 Gm27224 ENSMUST00000184749.3 Gm27224 (from geneSymbol) ENSMUST00000184749.1 ENSMUST00000184749.2 uc292jdt.1 uc292jdt.2 uc292jdt.3 uc292jdt.1 uc292jdt.2 uc292jdt.3 
ENSMUST00000184757.2 Hcrtr2 ENSMUST00000184757.2 hypocretin (orexin) receptor 2, transcript variant 2 (from RefSeq NM_001364551.1) ENSMUST00000184757.1 Mox2r NM_001364551 OX2R_MOUSE P58308 Q5SGC8 Q6VLX3 Q8BG12 uc009qta.1 uc009qta.2 uc009qta.3 Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=2b; IsoId=P58308-1; Sequence=Displayed; Name=2; Synonyms=2a; IsoId=P58308-2; Sequence=VSP_016466; Widely expressed. Isoform 2 not detected in skeletal muscle and kidney. The N-terminal region is required for orexin signaling. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity protein binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway neuropeptide signaling pathway feeding behavior regulation of circadian sleep/wake cycle, wakefulness membrane integral component of membrane orexin receptor activity peptide hormone binding circadian sleep/wake cycle process cellular response to hormone stimulus regulation of cytosolic calcium ion concentration uc009qta.1 uc009qta.2 uc009qta.3 
ENSMUST00000184761.3 Mir7662 ENSMUST00000184761.3 microRNA 7662 (from RefSeq NR_106122.1) ENSMUST00000184761.1 ENSMUST00000184761.2 NR_106122 uc033fpt.1 uc033fpt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fpt.1 uc033fpt.2 
ENSMUST00000184765.3 Mir7069 ENSMUST00000184765.3 microRNA 7069 (from RefSeq NR_106037.1) ENSMUST00000184765.1 ENSMUST00000184765.2 NR_106037 uc033jgk.1 uc033jgk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jgk.1 uc033jgk.2 
ENSMUST00000184769.3 Mir7001 ENSMUST00000184769.3 microRNA 7001 (from RefSeq NR_105967.1) ENSMUST00000184769.1 ENSMUST00000184769.2 NR_105967 uc033hor.1 uc033hor.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hor.1 uc033hor.2 
ENSMUST00000184772.2 Gm28047 ENSMUST00000184772.2 Nucleus (from UniProt Q3US59) AK140782 ENSMUST00000184772.1 Gm28047 Q3US59 Q3US59_MOUSE uc289buz.1 uc289buz.2 Nucleus Belongs to the bZIP family. nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated uc289buz.1 uc289buz.2 
ENSMUST00000184773.3 Mir8117 ENSMUST00000184773.3 microRNA 8117 (from RefSeq NR_106197.1) ENSMUST00000184773.1 ENSMUST00000184773.2 NR_106197 uc056zzt.1 uc056zzt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zzt.1 uc056zzt.2 
ENSMUST00000184774.3 Mir6972 ENSMUST00000184774.3 microRNA 6972 (from RefSeq NR_105938.1) ENSMUST00000184774.1 ENSMUST00000184774.2 NR_105938 uc033hcz.1 uc033hcz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hcz.1 uc033hcz.2 
ENSMUST00000184777.3 Mir7029 ENSMUST00000184777.3 microRNA 7029 (from RefSeq NR_105996.1) ENSMUST00000184777.1 ENSMUST00000184777.2 NR_105996 uc033ilm.1 uc033ilm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ilm.1 uc033ilm.2 
ENSMUST00000184784.3 Mir6419 ENSMUST00000184784.3 microRNA 6419 (from RefSeq NR_105847.1) ENSMUST00000184784.1 ENSMUST00000184784.2 NR_105847 uc033hlm.1 uc033hlm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hlm.1 uc033hlm.2 
ENSMUST00000184787.2 Gm27196 ENSMUST00000184787.2 Gm27196 (from geneSymbol) AK035055 ENSMUST00000184787.1 uc289uck.1 uc289uck.2 uc289uck.1 uc289uck.2 
ENSMUST00000184789.3 Mir6987 ENSMUST00000184789.3 microRNA 6987 (from RefSeq NR_105953.1) ENSMUST00000184789.1 ENSMUST00000184789.2 NR_105953 uc033hio.1 uc033hio.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hio.1 uc033hio.2 
ENSMUST00000184790.3 Mir6897 ENSMUST00000184790.3 microRNA 6897 (from RefSeq NR_105862.1) ENSMUST00000184790.1 ENSMUST00000184790.2 NR_105862 uc033fin.1 uc033fin.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fin.1 uc033fin.2 
ENSMUST00000184791.3 Mir7036b ENSMUST00000184791.3 microRNA 7036b (from RefSeq NR_106111.1) ENSMUST00000184791.1 ENSMUST00000184791.2 NR_106111 uc033iiu.1 uc033iiu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iiu.1 uc033iiu.2 
ENSMUST00000184793.3 Mir6769b ENSMUST00000184793.3 microRNA 6769b (from RefSeq NR_106035.1) ENSMUST00000184793.1 ENSMUST00000184793.2 NR_106035 uc033jgd.1 uc033jgd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jgd.1 uc033jgd.2 
ENSMUST00000184798.3 Mir6899 ENSMUST00000184798.3 microRNA 6899 (from RefSeq NR_105864.1) ENSMUST00000184798.1 ENSMUST00000184798.2 NR_105864 uc033fjg.1 uc033fjg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fjg.1 uc033fjg.2 
ENSMUST00000184804.4 Gm27991 ENSMUST00000184804.4 Gm27991 (from geneSymbol) ENSMUST00000184804.1 ENSMUST00000184804.2 ENSMUST00000184804.3 uc291vby.1 uc291vby.2 uc291vby.1 uc291vby.2 
ENSMUST00000184812.3 Mir6989 ENSMUST00000184812.3 microRNA 6989 (from RefSeq NR_105955.1) ENSMUST00000184812.1 ENSMUST00000184812.2 NR_105955 uc056zhj.1 uc056zhj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zhj.1 uc056zhj.2 
ENSMUST00000184814.3 Mir195b ENSMUST00000184814.3 microRNA 195b (from RefSeq NR_105751.1) ENSMUST00000184814.1 ENSMUST00000184814.2 NR_105751 uc033hmx.1 uc033hmx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hmx.1 uc033hmx.2 
ENSMUST00000184815.3 Mir7080 ENSMUST00000184815.3 microRNA 7080 (from RefSeq NR_106048.1) ENSMUST00000184815.1 ENSMUST00000184815.2 NR_106048 uc033jil.1 uc033jil.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jil.1 uc033jil.2 
ENSMUST00000184821.3 Mir7052 ENSMUST00000184821.3 microRNA 7052 (from RefSeq NR_106019.1) ENSMUST00000184821.1 ENSMUST00000184821.2 NR_106019 uc033iza.1 uc033iza.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iza.1 uc033iza.2 
ENSMUST00000184823.3 1700017I07Rik ENSMUST00000184823.3 1700017I07Rik (from geneSymbol) AK006067 ENSMUST00000184823.1 ENSMUST00000184823.2 uc292jnp.1 uc292jnp.2 uc292jnp.3 uc292jnp.1 uc292jnp.2 uc292jnp.3 
ENSMUST00000184825.3 Mir7059 ENSMUST00000184825.3 microRNA 7059 (from RefSeq NR_106026.1) ENSMUST00000184825.1 ENSMUST00000184825.2 NR_106026 uc033jcb.1 uc033jcb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jcb.1 uc033jcb.2 
ENSMUST00000184827.3 Mir6959 ENSMUST00000184827.3 microRNA 6959 (from RefSeq NR_105924.1) ENSMUST00000184827.1 ENSMUST00000184827.2 NR_105924 uc033gwb.1 uc033gwb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gwb.1 uc033gwb.2 
ENSMUST00000184833.3 Mir7038 ENSMUST00000184833.3 microRNA 7038 (from RefSeq NR_106005.1) ENSMUST00000184833.1 ENSMUST00000184833.2 NR_106005 uc033inl.1 uc033inl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033inl.1 uc033inl.2 
ENSMUST00000184834.3 Mir7681 ENSMUST00000184834.3 microRNA 7681 (from RefSeq NR_106149.1) ENSMUST00000184834.1 ENSMUST00000184834.2 NR_106149 uc033fjb.1 uc033fjb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fjb.1 uc033fjb.2 
ENSMUST00000184840.3 Mir7087 ENSMUST00000184840.3 microRNA 7087 (from RefSeq NR_106055.1) ENSMUST00000184840.1 ENSMUST00000184840.2 NR_106055 uc033jkd.1 uc033jkd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jkd.1 uc033jkd.2 
ENSMUST00000184841.3 Mir6931 ENSMUST00000184841.3 microRNA 6931 (from RefSeq NR_105896.1) ENSMUST00000184841.1 ENSMUST00000184841.2 NR_105896 uc033gan.1 uc033gan.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gan.1 uc033gan.2 
ENSMUST00000184847.3 Mir7071 ENSMUST00000184847.3 microRNA 7071 (from RefSeq NR_106039.1) ENSMUST00000184847.1 ENSMUST00000184847.2 NR_106039 uc033jgp.1 uc033jgp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jgp.1 uc033jgp.2 
ENSMUST00000184858.2 Mroh6 ENSMUST00000184858.2 maestro heat-like repeat family member 6 (from RefSeq NM_001282443.2) ENSMUST00000184858.1 Mroh6 NM_001282443 V9GX81 V9GX81_MOUSE uc033guj.1 uc033guj.2 uc033guj.3 molecular_function cellular_component biological_process uc033guj.1 uc033guj.2 uc033guj.3 
ENSMUST00000184863.8 Dexi ENSMUST00000184863.8 Belongs to the DEXI family. (from UniProt Q9WUQ7) AK032104 DEXI_MOUSE ENSMUST00000184863.1 ENSMUST00000184863.2 ENSMUST00000184863.3 ENSMUST00000184863.4 ENSMUST00000184863.5 ENSMUST00000184863.6 ENSMUST00000184863.7 Myle Q9WUQ7 uc033gxk.1 uc033gxk.2 uc033gxk.3 Belongs to the DEXI family. molecular_function cellular_component biological_process uc033gxk.1 uc033gxk.2 uc033gxk.3 
ENSMUST00000184870.2 Mir6400 ENSMUST00000184870.2 microRNA 6400 (from RefSeq NR_105826.1) ENSMUST00000184870.1 NR_105826 uc033iau.1 uc033iau.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iau.1 uc033iau.2 
ENSMUST00000184879.3 Mir6975 ENSMUST00000184879.3 microRNA 6975 (from RefSeq NR_105941.1) ENSMUST00000184879.1 ENSMUST00000184879.2 NR_105941 uc033hdi.1 uc033hdi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hdi.1 uc033hdi.2 
ENSMUST00000184880.3 Mir6363 ENSMUST00000184880.3 microRNA 6363 (from RefSeq NR_105782.1) ENSMUST00000184880.1 ENSMUST00000184880.2 NR_105782 uc033gzd.1 uc033gzd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gzd.1 uc033gzd.2 
ENSMUST00000184886.3 Mir6540 ENSMUST00000184886.3 microRNA 6540 (from RefSeq NR_105858.1) ENSMUST00000184886.1 ENSMUST00000184886.2 NR_105858 uc033gyz.1 uc033gyz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611777.1 [ECO:0000345] ##Evidence-Data-END## uc033gyz.1 uc033gyz.2 
ENSMUST00000184894.3 Mir7017 ENSMUST00000184894.3 microRNA 7017 (from RefSeq NR_105984.1) ENSMUST00000184894.1 ENSMUST00000184894.2 NR_105984 uc033ife.1 uc033ife.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ife.1 uc033ife.2 
ENSMUST00000184898.3 Mir6898 ENSMUST00000184898.3 microRNA 6898 (from RefSeq NR_105863.1) ENSMUST00000184898.1 ENSMUST00000184898.2 NR_105863 uc033fio.1 uc033fio.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fio.1 uc033fio.2 
ENSMUST00000184907.3 Mir7665 ENSMUST00000184907.3 microRNA 7665 (from RefSeq NR_106125.1) ENSMUST00000184907.1 ENSMUST00000184907.2 NR_106125 uc033hpp.1 uc033hpp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hpp.1 uc033hpp.2 
ENSMUST00000184910.3 Mir21c ENSMUST00000184910.3 microRNA 21c (from RefSeq NR_105822.1) ENSMUST00000184910.1 ENSMUST00000184910.2 NR_105822 uc033jin.1 uc033jin.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jin.1 uc033jin.2 
ENSMUST00000184912.3 Mir6993 ENSMUST00000184912.3 microRNA 6993 (from RefSeq NR_105959.1) ENSMUST00000184912.1 ENSMUST00000184912.2 NR_105959 uc033hjf.1 uc033hjf.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hjf.1 uc033hjf.2 
ENSMUST00000184917.6 Aoc1l1 ENSMUST00000184917.6 amine oxidase copper containing 1-like 1, transcript variant 2 (from RefSeq NR_160891.1) Aoc1l1 Doxl2 ENSMUST00000184917.1 ENSMUST00000184917.2 ENSMUST00000184917.3 ENSMUST00000184917.4 ENSMUST00000184917.5 NR_160891 Q6IMK7 Q6IMK7_MOUSE uc009bwd.1 uc009bwd.2 uc009bwd.3 Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence=; Note=Contains 1 topaquinone per subunit. ; Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. Belongs to the copper/topaquinone oxidase family. copper ion binding plasma membrane primary amine oxidase activity amine metabolic process oxidoreductase activity response to antibiotic metal ion binding quinone binding diamine oxidase activity oxidation-reduction process uc009bwd.1 uc009bwd.2 uc009bwd.3 
ENSMUST00000184919.3 Mir6967-2 ENSMUST00000184919.3 microRNA 6967-2 (from RefSeq NR_128569.1) ENSMUST00000184919.1 ENSMUST00000184919.2 NR_128569 uc056zdt.1 uc056zdt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zdt.1 uc056zdt.2 
ENSMUST00000184924.3 Mir6392 ENSMUST00000184924.3 microRNA 6392 (from RefSeq NR_105816.1) ENSMUST00000184924.1 ENSMUST00000184924.2 NR_105816 uc033gvs.1 uc033gvs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gvs.1 uc033gvs.2 
ENSMUST00000184935.3 Mir496b ENSMUST00000184935.3 microRNA 496b (from RefSeq NR_105832.1) ENSMUST00000184935.1 ENSMUST00000184935.2 NR_105832 uc033hjz.1 uc033hjz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hjz.1 uc033hjz.2 
ENSMUST00000184936.9 ENSMUSG00000121378 ENSMUST00000184936.9 ENSMUSG00000121378 (from geneSymbol) AK164215 ENSMUST00000184936.1 ENSMUST00000184936.2 ENSMUST00000184936.3 ENSMUST00000184936.4 ENSMUST00000184936.5 ENSMUST00000184936.6 ENSMUST00000184936.7 ENSMUST00000184936.8 uc289gqh.1 uc289gqh.2 uc289gqh.3 uc289gqh.1 uc289gqh.2 uc289gqh.3 
ENSMUST00000184939.3 Mir6347 ENSMUST00000184939.3 microRNA 6347 (from RefSeq NR_105765.1) ENSMUST00000184939.1 ENSMUST00000184939.2 NR_105765 uc056yet.1 uc056yet.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yet.1 uc056yet.2 
ENSMUST00000184943.3 Mir7689 ENSMUST00000184943.3 microRNA 7689 (from RefSeq NR_106162.1) ENSMUST00000184943.1 ENSMUST00000184943.2 NR_106162 uc056zzl.1 uc056zzl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zzl.1 uc056zzl.2 
ENSMUST00000184953.3 Mir7226 ENSMUST00000184953.3 microRNA 7226 (from RefSeq NR_106085.1) ENSMUST00000184953.1 ENSMUST00000184953.2 NR_106085 uc033iea.1 uc033iea.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iea.1 uc033iea.2 
ENSMUST00000184956.3 Mir8113 ENSMUST00000184956.3 microRNA 8113 (from RefSeq NR_106193.1) ENSMUST00000184956.1 ENSMUST00000184956.2 NR_106193 uc033iuv.1 uc033iuv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iuv.1 uc033iuv.2 
ENSMUST00000184957.3 Mir6409 ENSMUST00000184957.3 microRNA 6409 (from RefSeq NR_105836.1) ENSMUST00000184957.1 ENSMUST00000184957.2 NR_105836 uc033fqj.1 uc033fqj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fqj.1 uc033fqj.2 
ENSMUST00000184960.3 Mir6977 ENSMUST00000184960.3 microRNA 6977 (from RefSeq NR_105943.1) ENSMUST00000184960.1 ENSMUST00000184960.2 NR_105943 uc033hes.1 uc033hes.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hes.1 uc033hes.2 
ENSMUST00000184964.3 Mir7674 ENSMUST00000184964.3 microRNA 7674 (from RefSeq NR_106135.1) ENSMUST00000184964.1 ENSMUST00000184964.2 NR_106135 uc033hmm.1 uc033hmm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hmm.1 uc033hmm.2 
ENSMUST00000184973.8 Entpd4 ENSMUST00000184973.8 ectonucleoside triphosphate diphosphohydrolase 4, transcript variant 1 (from RefSeq NM_026174.3) ENSMUST00000184973.1 ENSMUST00000184973.2 ENSMUST00000184973.3 ENSMUST00000184973.4 ENSMUST00000184973.5 ENSMUST00000184973.6 ENSMUST00000184973.7 ENTP4_MOUSE Lalp70 Lysal1 NM_026174 Q9DBT4 uc029sle.1 uc029sle.2 uc029sle.3 [Isoform 1]: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP on UTP and TTP. AMP, ADP, ATP and UMP are not substrates. Preferentially activated by Ca(2+) over Mg(2+). [Isoform 2]: Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally. Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23681; Evidence=; Reaction=a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'- phosphate + H(+) + phosphate; Xref=Rhea:RHEA:36799, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:58043; EC=3.6.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36800; Evidence=; Reaction=H2O + UDP = H(+) + phosphate + UMP; Xref=Rhea:RHEA:64876, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57865, ChEBI:CHEBI:58223; EC=3.6.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64877; Evidence=; Reaction=H2O + UTP = H(+) + phosphate + UDP; Xref=Rhea:RHEA:64900, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398, ChEBI:CHEBI:58223; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64901; Evidence=; Reaction=CTP + H2O = CDP + H(+) + phosphate; Xref=Rhea:RHEA:29387, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:58069; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29388; Evidence=; Reaction=GDP + H2O = GMP + H(+) + phosphate; Xref=Rhea:RHEA:22156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189; EC=3.6.1.42; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22157; Evidence=; Reaction=H2O + TTP = H(+) + phosphate + TDP; Xref=Rhea:RHEA:65580, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:61417, ChEBI:CHEBI:63527; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65581; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; [Isoform 1]: Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein [Isoform 2]: Golgi apparatus membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=LALP70 ; IsoId=Q9DBT4-1; Sequence=Displayed; Name=2; Synonyms=LALP70V ; IsoId=Q9DBT4-2; Sequence=VSP_003615; Ubiquitous. Belongs to the GDA1/CD39 NTPase family. Golgi membrane autophagosome membrane Golgi apparatus membrane integral component of membrane hydrolase activity nucleoside-diphosphatase activity integral component of Golgi membrane cytoplasmic vesicle uridine-diphosphatase activity integral component of autophagosome membrane uc029sle.1 uc029sle.2 uc029sle.3 
ENSMUST00000184974.3 Mir6937 ENSMUST00000184974.3 microRNA 6937 (from RefSeq NR_105902.1) ENSMUST00000184974.1 ENSMUST00000184974.2 NR_105902 uc033gcx.1 uc033gcx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gcx.1 uc033gcx.2 
ENSMUST00000184979.3 Mir6354 ENSMUST00000184979.3 microRNA 6354 (from RefSeq NR_105772.1) ENSMUST00000184979.1 ENSMUST00000184979.2 NR_105772 uc056yev.1 uc056yev.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yev.1 uc056yev.2 
ENSMUST00000184981.3 Mir6939 ENSMUST00000184981.3 microRNA 6939 (from RefSeq NR_105904.1) ENSMUST00000184981.1 ENSMUST00000184981.2 NR_105904 uc033gfs.1 uc033gfs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gfs.1 uc033gfs.2 
ENSMUST00000184982.3 Mir6933 ENSMUST00000184982.3 microRNA 6933 (from RefSeq NR_105898.1) ENSMUST00000184982.1 ENSMUST00000184982.2 NR_105898 uc033gbq.1 uc033gbq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gbq.1 uc033gbq.2 
ENSMUST00000184986.2 Tac1 ENSMUST00000184986.2 tachykinin 1, transcript variant 2 (from RefSeq NM_001311060.2) ENSMUST00000184986.1 NM_001311060 Nka Nkna P41539 Q00073 TKN1_MOUSE Tac2 uc009axd.1 uc009axd.2 uc009axd.3 uc009axd.4 uc009axd.5 Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Secreted. Event=Alternative splicing; Named isoforms=4; Name=Beta; IsoId=P41539-1; Sequence=Displayed; Name=Alpha; IsoId=P41539-3; Sequence=Not described; Name=Gamma; IsoId=P41539-2; Sequence=VSP_006379; Name=Delta; IsoId=P41539-4; Sequence=Not described; [Substance P]: The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME). Belongs to the tachykinin family. response to yeast positive regulation of acute inflammatory response negative regulation of systemic arterial blood pressure extracellular region extracellular space plasma membrane inflammatory response positive regulation of cytosolic calcium ion concentration tachykinin receptor signaling pathway neuropeptide signaling pathway chemical synaptic transmission long-term memory regulation of blood pressure associative learning response to hormone negative regulation of heart rate positive regulation of epithelial cell migration sensory perception of pain antibacterial humoral response antifungal humoral response axon killing of cells of other organism substance P receptor binding neuromedin K receptor binding substance K receptor binding positive regulation of synaptic transmission, cholinergic positive regulation of synaptic transmission, GABAergic response to lipopolysaccharide positive regulation of renal sodium excretion neuronal cell body response to morphine innate immune response positive regulation of action potential positive regulation of ossification positive regulation of saliva secretion receptor agonist activity response to pain positive regulation of lymphocyte proliferation defense response to Gram-negative bacterium defense response to Gram-positive bacterium detection of temperature stimulus involved in sensory perception of pain positive regulation of stress fiber assembly regulation of sensory perception of pain negative regulation of neuron death positive regulation of neuron death positive regulation of flagellated sperm motility positive regulation of sensory perception of pain cellular response to nerve growth factor stimulus positive regulation of corticosterone secretion uc009axd.1 uc009axd.2 uc009axd.3 uc009axd.4 uc009axd.5 
ENSMUST00000184990.3 Mir6715 ENSMUST00000184990.3 microRNA 6715 (from RefSeq NR_106146.1) ENSMUST00000184990.1 ENSMUST00000184990.2 NR_106146 uc033hkx.1 uc033hkx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hkx.1 uc033hkx.2 
ENSMUST00000184992.3 Mir8115 ENSMUST00000184992.3 microRNA 8115 (from RefSeq NR_106195.1) ENSMUST00000184992.1 ENSMUST00000184992.2 NR_106195 uc057abn.1 uc057abn.2 uc057abn.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057abn.1 uc057abn.2 uc057abn.3 
ENSMUST00000184995.2 Gm27207 ENSMUST00000184995.2 Gm27207 (from geneSymbol) ENSMUST00000184995.1 uc292bvd.1 uc292bvd.2 uc292bvd.1 uc292bvd.2 
ENSMUST00000184998.3 Mir8108 ENSMUST00000184998.3 microRNA 8108 (from RefSeq NR_106187.1) ENSMUST00000184998.1 ENSMUST00000184998.2 NR_106187 uc033jes.1 uc033jes.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jes.1 uc033jes.2 
ENSMUST00000184999.3 Mir6914 ENSMUST00000184999.3 microRNA 6914 (from RefSeq NR_105879.1) ENSMUST00000184999.1 ENSMUST00000184999.2 NR_105879 uc033ftd.1 uc033ftd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ftd.1 uc033ftd.2 
ENSMUST00000185006.9 Tmem254 ENSMUST00000185006.9 transmembrane protein 254, transcript variant 1 (from RefSeq NM_026679.2) D14Ertd449e ENSMUST00000185006.1 ENSMUST00000185006.2 ENSMUST00000185006.3 ENSMUST00000185006.4 ENSMUST00000185006.5 ENSMUST00000185006.6 ENSMUST00000185006.7 ENSMUST00000185006.8 F6V0T5 NM_026679 P0DN89 P0DN90 P0DN91 Q9D890 Q9DCV5 TM254_MOUSE Tmem254 Tmem254a Tmem254b Tmem254c uc007sry.1 uc007sry.2 uc007sry.3 uc007sry.4 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P0DN89-1; Sequence=Displayed; Name=2; IsoId=P0DN89-2; Sequence=VSP_058265; molecular_function cellular_component biological_process membrane integral component of membrane uc007sry.1 uc007sry.2 uc007sry.3 uc007sry.4 
ENSMUST00000185007.3 Mir6403 ENSMUST00000185007.3 microRNA 6403 (from RefSeq NR_105829.1) ENSMUST00000185007.1 ENSMUST00000185007.2 NR_105829 uc033ifm.1 uc033ifm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ifm.1 uc033ifm.2 
ENSMUST00000185013.2 Gm27241 ENSMUST00000185013.2 Gm27241 (from geneSymbol) ENSMUST00000185013.1 uc292irg.1 uc292irg.2 uc292irg.1 uc292irg.2 
ENSMUST00000185015.2 Gm27151 ENSMUST00000185015.2 predicted gene 27151 (from RefSeq NR_168265.1) ENSMUST00000185015.1 NR_168265 uc289rkp.1 uc289rkp.2 uc289rkp.1 uc289rkp.2 
ENSMUST00000185016.3 Mir7028 ENSMUST00000185016.3 microRNA 7028 (from RefSeq NR_105995.1) ENSMUST00000185016.1 ENSMUST00000185016.2 NR_105995 uc033ilj.1 uc033ilj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ilj.1 uc033ilj.2 
ENSMUST00000185022.3 Gm27811 ENSMUST00000185022.3 Gm27811 (from geneSymbol) ENSMUST00000185022.1 ENSMUST00000185022.2 uc290ghh.1 uc290ghh.2 uc290ghh.1 uc290ghh.2 
ENSMUST00000185032.3 Mir6420 ENSMUST00000185032.3 microRNA 6420 (from RefSeq NR_105848.1) ENSMUST00000185032.1 ENSMUST00000185032.2 NR_105848 uc033hew.1 uc033hew.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hew.1 uc033hew.2 
ENSMUST00000185033.3 Gm27414 ENSMUST00000185033.3 Gm27414 (from geneSymbol) ENSMUST00000185033.1 ENSMUST00000185033.2 uc292qfw.1 uc292qfw.2 uc292qfw.1 uc292qfw.2 
ENSMUST00000185035.3 Mir8120 ENSMUST00000185035.3 microRNA 8120 (from RefSeq NR_106200.1) ENSMUST00000185035.1 ENSMUST00000185035.2 NR_106200 uc033hua.1 uc033hua.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hua.1 uc033hua.2 
ENSMUST00000185038.3 Mir7062 ENSMUST00000185038.3 microRNA 7062 (from RefSeq NR_106029.1) ENSMUST00000185038.1 ENSMUST00000185038.2 NR_106029 uc033jcu.1 uc033jcu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jcu.1 uc033jcu.2 
ENSMUST00000185043.3 Mir8093 ENSMUST00000185043.3 microRNA 8093 (from RefSeq NR_106168.1) ENSMUST00000185043.1 ENSMUST00000185043.2 NR_106168 uc289vem.1 uc289vem.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc289vem.1 uc289vem.2 
ENSMUST00000185044.3 Mir6932 ENSMUST00000185044.3 microRNA 6932 (from RefSeq NR_105897.1) ENSMUST00000185044.1 ENSMUST00000185044.2 NR_105897 uc033gay.1 uc033gay.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gay.1 uc033gay.2 
ENSMUST00000185054.3 Mir7119 ENSMUST00000185054.3 microRNA 7119 (from RefSeq NR_106067.1) ENSMUST00000185054.1 ENSMUST00000185054.2 NR_106067 uc033iek.1 uc033iek.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iek.1 uc033iek.2 
ENSMUST00000185057.2 ENSMUSG00000121751 ENSMUST00000185057.2 ENSMUSG00000121751 (from geneSymbol) AK133428 ENSMUST00000185057.1 uc292nmu.1 uc292nmu.2 uc292nmu.1 uc292nmu.2 
ENSMUST00000185062.3 Mir6901 ENSMUST00000185062.3 microRNA 6901 (from RefSeq NR_105866.1) ENSMUST00000185062.1 ENSMUST00000185062.2 NR_105866 uc033fkr.1 uc033fkr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fkr.1 uc033fkr.2 
ENSMUST00000185063.3 Mir6980 ENSMUST00000185063.3 microRNA 6980 (from RefSeq NR_105946.1) ENSMUST00000185063.1 ENSMUST00000185063.2 NR_105946 uc033hgo.1 uc033hgo.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hgo.1 uc033hgo.2 
ENSMUST00000185072.8 Entpd4b ENSMUST00000185072.8 ectonucleoside triphosphate diphosphohydrolase 4B, transcript variant 2 (from RefSeq NM_001359160.1) ENSMUST00000185072.1 ENSMUST00000185072.2 ENSMUST00000185072.3 ENSMUST00000185072.4 ENSMUST00000185072.5 ENSMUST00000185072.6 ENSMUST00000185072.7 ENTP4_MOUSE Entpd4 Lalp70 Lysal1 NM_001359160 Q9DBT4 uc007umi.1 uc007umi.2 uc007umi.3 uc007umi.4 uc007umi.5 [Isoform 1]: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP on UTP and TTP. AMP, ADP, ATP and UMP are not substrates. Preferentially activated by Ca(2+) over Mg(2+). [Isoform 2]: Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally. Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23681; Evidence=; Reaction=a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'- phosphate + H(+) + phosphate; Xref=Rhea:RHEA:36799, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:58043; EC=3.6.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36800; Evidence=; Reaction=H2O + UDP = H(+) + phosphate + UMP; Xref=Rhea:RHEA:64876, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57865, ChEBI:CHEBI:58223; EC=3.6.1.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64877; Evidence=; Reaction=H2O + UTP = H(+) + phosphate + UDP; Xref=Rhea:RHEA:64900, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398, ChEBI:CHEBI:58223; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64901; Evidence=; Reaction=CTP + H2O = CDP + H(+) + phosphate; Xref=Rhea:RHEA:29387, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:58069; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29388; Evidence=; Reaction=GDP + H2O = GMP + H(+) + phosphate; Xref=Rhea:RHEA:22156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189; EC=3.6.1.42; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22157; Evidence=; Reaction=H2O + TTP = H(+) + phosphate + TDP; Xref=Rhea:RHEA:65580, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:61417, ChEBI:CHEBI:63527; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65581; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; [Isoform 1]: Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein [Isoform 2]: Golgi apparatus membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=LALP70 ; IsoId=Q9DBT4-1; Sequence=Displayed; Name=2; Synonyms=LALP70V ; IsoId=Q9DBT4-2; Sequence=VSP_003615; Ubiquitous. Belongs to the GDA1/CD39 NTPase family. Golgi membrane autophagosome membrane Golgi apparatus membrane integral component of membrane hydrolase activity nucleoside-diphosphatase activity integral component of Golgi membrane cytoplasmic vesicle uridine-diphosphatase activity integral component of autophagosome membrane uc007umi.1 uc007umi.2 uc007umi.3 uc007umi.4 uc007umi.5 
ENSMUST00000185075.3 Mir6418 ENSMUST00000185075.3 microRNA 6418 (from RefSeq NR_105846.1) ENSMUST00000185075.1 ENSMUST00000185075.2 NR_105846 uc033inb.1 uc033inb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611682.1 [ECO:0000345] ##Evidence-Data-END## uc033inb.1 uc033inb.2 
ENSMUST00000185076.3 Mir7678 ENSMUST00000185076.3 microRNA 7678 (from RefSeq NR_106143.1) ENSMUST00000185076.1 ENSMUST00000185076.2 NR_106143 uc033hrh.1 uc033hrh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hrh.1 uc033hrh.2 
ENSMUST00000185077.3 Mir6929 ENSMUST00000185077.3 microRNA 6929 (from RefSeq NR_105894.1) ENSMUST00000185077.1 ENSMUST00000185077.2 NR_105894 uc033gag.1 uc033gag.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gag.1 uc033gag.2 
ENSMUST00000185078.3 Mir8090 ENSMUST00000185078.3 microRNA 8090 (from RefSeq NR_106165.1) ENSMUST00000185078.1 ENSMUST00000185078.2 NR_106165 uc056zir.1 uc056zir.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zir.1 uc056zir.2 
ENSMUST00000185079.3 Mir6361 ENSMUST00000185079.3 microRNA 6361 (from RefSeq NR_105779.1) ENSMUST00000185079.1 ENSMUST00000185079.2 NR_105779 uc033hga.1 uc033hga.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hga.1 uc033hga.2 
ENSMUST00000185080.3 Mir3569 ENSMUST00000185080.3 microRNA 3569 (from RefSeq NR_106134.1) ENSMUST00000185080.1 ENSMUST00000185080.2 NR_106134 uc033iyi.1 uc033iyi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iyi.1 uc033iyi.2 
ENSMUST00000185082.3 Mir7654 ENSMUST00000185082.3 microRNA 7654 (from RefSeq NR_106114.1) ENSMUST00000185082.1 ENSMUST00000185082.2 NR_106114 uc291yas.1 uc291yas.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc291yas.1 uc291yas.2 
ENSMUST00000185083.2 ENSMUSG00000121684 ENSMUST00000185083.2 ENSMUSG00000121684 (from geneSymbol) AK015499 ENSMUST00000185083.1 uc288isg.1 uc288isg.2 uc288isg.1 uc288isg.2 
ENSMUST00000185089.3 Mir7005 ENSMUST00000185089.3 microRNA 7005 (from RefSeq NR_105972.1) ENSMUST00000185089.1 ENSMUST00000185089.2 NR_105972 uc033hrw.1 uc033hrw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hrw.1 uc033hrw.2 
ENSMUST00000185091.2 Tlr11 ENSMUST00000185091.2 toll-like receptor 11 (from RefSeq NM_205819.3) ENSMUST00000185091.1 NM_205819 Tlr11 V9GWT0 V9GWT0_MOUSE uc033gps.1 uc033gps.2 Membrane ; Single- pass type I membrane protein Belongs to the Toll-like receptor family. signal transduction membrane integral component of membrane uc033gps.1 uc033gps.2 
ENSMUST00000185092.3 Mir6952 ENSMUST00000185092.3 microRNA 6952 (from RefSeq NR_105917.1) ENSMUST00000185092.1 ENSMUST00000185092.2 NR_105917 uc033gup.1 uc033gup.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gup.1 uc033gup.2 
ENSMUST00000185093.3 Mir7023 ENSMUST00000185093.3 microRNA 7023 (from RefSeq NR_105990.1) ENSMUST00000185093.1 ENSMUST00000185093.2 NR_105990 uc033igw.1 uc033igw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033igw.1 uc033igw.2 
ENSMUST00000185099.3 Mir6922 ENSMUST00000185099.3 microRNA 6922 (from RefSeq NR_105887.1) ENSMUST00000185099.1 ENSMUST00000185099.2 NR_105887 uc033fvy.1 uc033fvy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fvy.1 uc033fvy.2 
ENSMUST00000185103.3 Mir8095 ENSMUST00000185103.3 microRNA 8095 (from RefSeq NR_106170.1) ENSMUST00000185103.1 ENSMUST00000185103.2 NR_106170 uc033gym.1 uc033gym.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gym.1 uc033gym.2 
ENSMUST00000185105.3 Mir6984 ENSMUST00000185105.3 microRNA 6984 (from RefSeq NR_105950.1) ENSMUST00000185105.1 ENSMUST00000185105.2 NR_105950 uc033hie.1 uc033hie.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hie.1 uc033hie.2 
ENSMUST00000185107.3 Mir7216 ENSMUST00000185107.3 microRNA 7216 (from RefSeq NR_106075.1) ENSMUST00000185107.1 ENSMUST00000185107.2 NR_106075 uc033hch.1 uc033hch.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hch.1 uc033hch.2 
ENSMUST00000185110.3 Mir7065 ENSMUST00000185110.3 microRNA 7065 (from RefSeq NR_106032.1) ENSMUST00000185110.1 ENSMUST00000185110.2 NR_106032 uc033jem.1 uc033jem.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jem.1 uc033jem.2 
ENSMUST00000185114.3 Mir6372 ENSMUST00000185114.3 microRNA 6372 (from RefSeq NR_105791.1) ENSMUST00000185114.1 ENSMUST00000185114.2 NR_105791 uc033fuc.1 uc033fuc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fuc.1 uc033fuc.2 
ENSMUST00000185115.8 Arfgap1 ENSMUST00000185115.8 ADP-ribosylation factor GTPase activating protein 1, transcript variant 10 (from RefSeq NM_001374670.1) Arfgap1 ENSMUST00000185115.1 ENSMUST00000185115.2 ENSMUST00000185115.3 ENSMUST00000185115.4 ENSMUST00000185115.5 ENSMUST00000185115.6 ENSMUST00000185115.7 NM_001374670 V9GXM1 V9GXM1_MOUSE uc290dku.1 uc290dku.2 GTPase activator activity positive regulation of GTPase activity metal ion binding uc290dku.1 uc290dku.2 
ENSMUST00000185120.3 Mir6339 ENSMUST00000185120.3 microRNA 6339 (from RefSeq NR_105757.1) ENSMUST00000185120.1 ENSMUST00000185120.2 NR_105757 uc033hqc.1 uc033hqc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hqc.1 uc033hqc.2 
ENSMUST00000185121.8 Zfhx2os ENSMUST00000185121.8 Zfhx2os (from geneSymbol) BC096537 ENSMUST00000185121.1 ENSMUST00000185121.2 ENSMUST00000185121.3 ENSMUST00000185121.4 ENSMUST00000185121.5 ENSMUST00000185121.6 ENSMUST00000185121.7 uc007txy.1 uc007txy.2 uc007txy.3 uc007txy.4 uc007txy.1 uc007txy.2 uc007txy.3 uc007txy.4 
ENSMUST00000185122.8 0610031O16Rik ENSMUST00000185122.8 RIKEN cDNA 0610031O16 gene (from RefSeq NR_045760.1) ENSMUST00000185122.1 ENSMUST00000185122.2 ENSMUST00000185122.3 ENSMUST00000185122.4 ENSMUST00000185122.5 ENSMUST00000185122.6 ENSMUST00000185122.7 NR_045760 uc008rnc.1 uc008rnc.2 uc008rnc.3 uc008rnc.4 uc008rnc.1 uc008rnc.2 uc008rnc.3 uc008rnc.4 
ENSMUST00000185125.8 Ssxb8 ENSMUST00000185125.8 Belongs to the SSX family. (from UniProt B1AY40) AY244799 B1AY40 B1AY40_MOUSE ENSMUST00000185125.1 ENSMUST00000185125.2 ENSMUST00000185125.3 ENSMUST00000185125.4 ENSMUST00000185125.5 ENSMUST00000185125.6 ENSMUST00000185125.7 Gm6592 Ssxb8 uc292ndt.1 uc292ndt.2 Belongs to the SSX family. nucleic acid binding nucleus regulation of transcription, DNA-templated uc292ndt.1 uc292ndt.2 
ENSMUST00000185129.3 Mir6967-1 ENSMUST00000185129.3 microRNA 6967-1 (from RefSeq NR_105933.1) ENSMUST00000185129.1 ENSMUST00000185129.2 NR_105933 uc056zek.1 uc056zek.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611901.1, LM611787.1 [ECO:0000345] ##Evidence-Data-END## uc056zek.1 uc056zek.2 
ENSMUST00000185131.8 Meis1 ENSMUST00000185131.8 Meis homeobox 1, transcript variant A (from RefSeq NM_010789.3) B1ARH5 ENSMUST00000185131.1 ENSMUST00000185131.2 ENSMUST00000185131.3 ENSMUST00000185131.4 ENSMUST00000185131.5 ENSMUST00000185131.6 ENSMUST00000185131.7 MEIS1_MOUSE NM_010789 Q5SVC8 Q60954 Q60955 Q8CIL0 uc007icl.1 uc007icl.2 uc007icl.3 Acts as a transcriptional regulator of PAX6. Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner. Heterodimer with DLX3. Heterodimer with HOXB13 (By similarity). Q60954-2; Q62424: Hoxa13; NbExp=3; IntAct=EBI-445723, EBI-925160; Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Meis1A; IsoId=Q60954-1; Sequence=Displayed; Name=2; Synonyms=Meis1B; IsoId=Q60954-2; Sequence=VSP_002240; Name=3; IsoId=Q60954-3; Sequence=VSP_017056; Expressed at high levels in the lung with lower levels detected in the heart and brain. Expressed in pancreatic islets (beta-cells and non-beta-cells) (PubMed:21059917). Expressed at high levels in all stages of embryonic development analyzed (7 days to 17 days). Expression is coactivated by retroviral integration in BXH-2 murine myeloid leukemias. Note=Meis1 serves as a site of viral integration in 15% of the tumors arising in BXH-2 mice that develop myeloid leukemia as a result of the expression of an ecotropic murine leukemia virus. Mice die between embryonic days 11.5 and 14.5, showing internal hemorrhage, liver hypoplasia and anemia. Belongs to the TALE/MEIS homeobox family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding angiogenesis lens morphogenesis in camera-type eye DNA binding chromatin binding protein binding nucleus nucleoplasm transcription factor complex regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development locomotory behavior hemopoiesis megakaryocyte development sequence-specific DNA binding negative regulation of myeloid cell differentiation negative regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity blood vessel morphogenesis negative regulation of cardiac muscle cell proliferation definitive hemopoiesis uc007icl.1 uc007icl.2 uc007icl.3 
ENSMUST00000185132.2 Gm27159 ENSMUST00000185132.2 Gm27159 (from geneSymbol) ENSMUST00000185132.1 uc292ioz.1 uc292ioz.2 uc292ioz.1 uc292ioz.2 
ENSMUST00000185146.3 Mir6919 ENSMUST00000185146.3 microRNA 6919 (from RefSeq NR_105884.1) ENSMUST00000185146.1 ENSMUST00000185146.2 NR_105884 uc033fvh.1 uc033fvh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fvh.1 uc033fvh.2 
ENSMUST00000185147.8 Smim22 ENSMUST00000185147.8 small integral membrane protein 22, transcript variant 4 (from RefSeq NM_001253803.1) ENSMUST00000185147.1 ENSMUST00000185147.2 ENSMUST00000185147.3 ENSMUST00000185147.4 ENSMUST00000185147.5 ENSMUST00000185147.6 ENSMUST00000185147.7 NM_001253803 Smim22 V9GXA9 V9GXA9_MOUSE uc029svw.1 uc029svw.2 uc029svw.3 uc029svw.4 Membrane ; Single- pass membrane protein molecular_function cellular_component membrane integral component of membrane positive regulation of cell migration regulation of actin cytoskeleton organization regulation of cell proliferation regulation of cell cycle uc029svw.1 uc029svw.2 uc029svw.3 uc029svw.4 
ENSMUST00000185149.3 Mir6376 ENSMUST00000185149.3 microRNA 6376 (from RefSeq NR_105795.1) ENSMUST00000185149.1 ENSMUST00000185149.2 NR_105795 uc033ith.1 uc033ith.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ith.1 uc033ith.2 
ENSMUST00000185150.3 Mir8097 ENSMUST00000185150.3 microRNA 8097 (from RefSeq NR_106173.1) ENSMUST00000185150.1 ENSMUST00000185150.2 NR_106173 uc033gtm.1 uc033gtm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gtm.1 uc033gtm.2 
ENSMUST00000185154.3 Mir7032 ENSMUST00000185154.3 microRNA 7032 (from RefSeq NR_105999.1) ENSMUST00000185154.1 ENSMUST00000185154.2 NR_105999 uc033imb.1 uc033imb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033imb.1 uc033imb.2 
ENSMUST00000185156.3 Mir7652 ENSMUST00000185156.3 microRNA 7652 (from RefSeq NR_106112.1) ENSMUST00000185156.1 ENSMUST00000185156.2 NR_106112 uc056yku.1 uc056yku.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yku.1 uc056yku.2 
ENSMUST00000185165.3 Mir8104 ENSMUST00000185165.3 microRNA 8104 (from RefSeq NR_106182.1) ENSMUST00000185165.1 ENSMUST00000185165.2 NR_106182 uc033fsv.1 uc033fsv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fsv.1 uc033fsv.2 
ENSMUST00000185166.3 Mir6928 ENSMUST00000185166.3 microRNA 6928 (from RefSeq NR_105893.1) ENSMUST00000185166.1 ENSMUST00000185166.2 NR_105893 uc033gae.1 uc033gae.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gae.1 uc033gae.2 
ENSMUST00000185173.2 Gm7467 ENSMUST00000185173.2 predicted gene 7467 (from RefSeq NR_152171.1) ENSMUST00000185173.1 NR_152171 uc290wnc.1 uc290wnc.2 uc290wnc.1 uc290wnc.2 
ENSMUST00000185176.8 Lzts1 ENSMUST00000185176.8 leucine zipper, putative tumor suppressor 1, transcript variant 1 (from RefSeq NM_199364.3) B2RTI1 ENSMUST00000185176.1 ENSMUST00000185176.2 ENSMUST00000185176.3 ENSMUST00000185176.4 ENSMUST00000185176.5 ENSMUST00000185176.6 ENSMUST00000185176.7 Fez1 LZTS1_MOUSE NM_199364 P60853 uc292ajv.1 uc292ajv.2 Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity). Binds EEF1G, TLK2 and CDK1. Cytoplasm Cell membrane Cell projection, dendritic spine Postsynaptic density Synapse Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). Phosphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression (By similarity). Belongs to the LZTS family. cytoplasm plasma membrane cell cycle microtubule binding postsynaptic density membrane negative regulation of macroautophagy apical plasma membrane cell junction cell projection neuron projection dendritic spine dendritic shaft cell body mitotic cell cycle phase transition synapse postsynaptic membrane regulation of synaptic plasticity regulation of dendrite morphogenesis uc292ajv.1 uc292ajv.2 
ENSMUST00000185184.2 Tcf24 ENSMUST00000185184.2 transcription factor 24 (from RefSeq NM_001285425.2) ENSMUST00000185184.1 NM_001285425 Tcf24 V9GWT9 V9GWT9_MOUSE uc033fhz.1 uc033fhz.2 uc033fhz.3 molecular_function cellular_component biological_process protein dimerization activity uc033fhz.1 uc033fhz.2 uc033fhz.3 
ENSMUST00000185186.3 Mir6943 ENSMUST00000185186.3 microRNA 6943 (from RefSeq NR_105908.1) ENSMUST00000185186.1 ENSMUST00000185186.2 NR_105908 uc033glx.1 uc033glx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033glx.1 uc033glx.2 
ENSMUST00000185190.3 Mir7649 ENSMUST00000185190.3 microRNA 7649 (from RefSeq NR_106107.1) ENSMUST00000185190.1 ENSMUST00000185190.2 NR_106107 uc291jif.1 uc291jif.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc291jif.1 uc291jif.2 
ENSMUST00000185191.2 Gm27231 ENSMUST00000185191.2 Gm27231 (from geneSymbol) ENSMUST00000185191.1 uc292iqh.1 uc292iqh.2 uc292iqh.1 uc292iqh.2 
ENSMUST00000185195.4 Gm55004 ENSMUST00000185195.4 Gm55004 (from geneSymbol) ENSMUST00000185195.1 ENSMUST00000185195.2 ENSMUST00000185195.3 uc291zwz.1 uc291zwz.2 uc291zwz.1 uc291zwz.2 
ENSMUST00000185206.2 Gm28541 ENSMUST00000185206.2 Gm28541 (from geneSymbol) ENSMUST00000185206.1 uc292upw.1 uc292upw.2 uc292upw.1 uc292upw.2 
ENSMUST00000185207.2 Gm29082 ENSMUST00000185207.2 Gm29082 (from geneSymbol) ENSMUST00000185207.1 uc292udz.1 uc292udz.2 uc292udz.1 uc292udz.2 
ENSMUST00000185211.4 2610016A17Rik ENSMUST00000185211.4 2610016A17Rik (from geneSymbol) AK011408 ENSMUST00000185211.1 ENSMUST00000185211.2 ENSMUST00000185211.3 uc008hbl.1 uc008hbl.2 uc008hbl.3 uc008hbl.4 uc008hbl.5 uc008hbl.1 uc008hbl.2 uc008hbl.3 uc008hbl.4 uc008hbl.5 
ENSMUST00000185217.2 Gm28462 ENSMUST00000185217.2 Gm28462 (from geneSymbol) ENSMUST00000185217.1 uc292ufw.1 uc292ufw.2 uc292ufw.1 uc292ufw.2 
ENSMUST00000185222.2 Gm28405 ENSMUST00000185222.2 Gm28405 (from geneSymbol) ENSMUST00000185222.1 uc292uys.1 uc292uys.2 uc292uys.1 uc292uys.2 
ENSMUST00000185236.2 Gm28311 ENSMUST00000185236.2 Gm28311 (from geneSymbol) ENSMUST00000185236.1 uc292thq.1 uc292thq.2 uc292thq.1 uc292thq.2 
ENSMUST00000185237.2 Gm28432 ENSMUST00000185237.2 Gm28432 (from geneSymbol) ENSMUST00000185237.1 uc292uic.1 uc292uic.2 uc292uic.1 uc292uic.2 
ENSMUST00000185240.2 Gm20897 ENSMUST00000185240.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE ENSMUST00000185240.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292tek.1 uc292tek.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292tek.1 uc292tek.2 
ENSMUST00000185245.2 Gm20883 ENSMUST00000185245.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE BC100464 ENSMUST00000185245.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292tmx.1 uc292tmx.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292tmx.1 uc292tmx.2 
ENSMUST00000185248.2 Gm29255 ENSMUST00000185248.2 Gm29255 (from geneSymbol) ENSMUST00000185248.1 uc292umd.1 uc292umd.2 uc292umd.1 uc292umd.2 
ENSMUST00000185286.2 Gm28126 ENSMUST00000185286.2 Gm28126 (from geneSymbol) ENSMUST00000185286.1 uc292utj.1 uc292utj.2 uc292utj.1 uc292utj.2 
ENSMUST00000185287.2 Gm28298 ENSMUST00000185287.2 Gm28298 (from geneSymbol) ENSMUST00000185287.1 uc292sxk.1 uc292sxk.2 uc292sxk.1 uc292sxk.2 
ENSMUST00000185289.2 Gm29364 ENSMUST00000185289.2 Gm29364 (from geneSymbol) ENSMUST00000185289.1 uc292sdr.1 uc292sdr.2 uc292sdr.1 uc292sdr.2 
ENSMUST00000185290.2 Gm28065 ENSMUST00000185290.2 Gm28065 (from geneSymbol) ENSMUST00000185290.1 uc287gtw.1 uc287gtw.2 uc287gtw.1 uc287gtw.2 
ENSMUST00000185293.7 Gm28127 ENSMUST00000185293.7 Gm28127 (from geneSymbol) ENSMUST00000185293.1 ENSMUST00000185293.2 ENSMUST00000185293.3 ENSMUST00000185293.4 ENSMUST00000185293.5 ENSMUST00000185293.6 uc292sve.1 uc292sve.2 uc292sve.1 uc292sve.2 
ENSMUST00000185300.2 Gm28485 ENSMUST00000185300.2 Gm28485 (from geneSymbol) ENSMUST00000185300.1 uc292ujn.1 uc292ujn.2 uc292ujn.1 uc292ujn.2 
ENSMUST00000185303.2 Gm28370 ENSMUST00000185303.2 Gm28370 (from geneSymbol) ENSMUST00000185303.1 uc288hon.1 uc288hon.2 uc288hon.1 uc288hon.2 
ENSMUST00000185304.2 Gm28375 ENSMUST00000185304.2 Gm28375 (from geneSymbol) ENSMUST00000185304.1 uc287kbp.1 uc287kbp.2 uc287kbp.1 uc287kbp.2 
ENSMUST00000185308.2 Gm29318 ENSMUST00000185308.2 Gm29318 (from geneSymbol) ENSMUST00000185308.1 uc288oua.1 uc288oua.2 uc288oua.1 uc288oua.2 
ENSMUST00000185309.3 1700009J07Rik ENSMUST00000185309.3 RIKEN cDNA 1700009J07 gene (from RefSeq NR_015547.1) ENSMUST00000185309.1 ENSMUST00000185309.2 NR_015547 uc007fwh.1 uc007fwh.2 uc007fwh.3 uc007fwh.4 uc007fwh.5 uc007fwh.1 uc007fwh.2 uc007fwh.3 uc007fwh.4 uc007fwh.5 
ENSMUST00000185311.2 Gm21842 ENSMUST00000185311.2 Gm21842 (from geneSymbol) ENSMUST00000185311.1 FJ386436 uc292sxz.1 uc292sxz.2 uc292sxz.1 uc292sxz.2 
ENSMUST00000185312.3 Gm28703 ENSMUST00000185312.3 predicted gene 28703 (from RefSeq NR_166895.1) ENSMUST00000185312.1 ENSMUST00000185312.2 NR_166895 uc009rae.1 uc009rae.2 uc009rae.3 uc009rae.1 uc009rae.2 uc009rae.3 
ENSMUST00000185321.2 Gm28081 ENSMUST00000185321.2 Gm28081 (from geneSymbol) ENSMUST00000185321.1 uc292ugr.1 uc292ugr.2 uc292ugr.1 uc292ugr.2 
ENSMUST00000185322.7 Gm28176 ENSMUST00000185322.7 Gm28176 (from geneSymbol) ENSMUST00000185322.1 ENSMUST00000185322.2 ENSMUST00000185322.3 ENSMUST00000185322.4 ENSMUST00000185322.5 ENSMUST00000185322.6 uc292tev.1 uc292tev.2 uc292tev.1 uc292tev.2 
ENSMUST00000185327.7 Gm21117 ENSMUST00000185327.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WPJ9) A0A087WPJ9 A0A087WPJ9_MOUSE ENSMUST00000185327.1 ENSMUST00000185327.2 ENSMUST00000185327.3 ENSMUST00000185327.4 ENSMUST00000185327.5 ENSMUST00000185327.6 FJ541091 Gm21117 uc292tnj.1 uc292tnj.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292tnj.1 uc292tnj.2 
ENSMUST00000185333.2 Kcna6 ENSMUST00000185333.2 potassium voltage-gated channel, shaker-related, subfamily, member 6, transcript variant 1 (from RefSeq NM_013568.7) ENSMUST00000185333.1 KCNA6_MOUSE NM_013568 Q61923 uc033ivb.1 uc033ivb.2 uc033ivb.3 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient (By similarity). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (By similarity). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (By similarity). Homotetramer and heterotetramer of potassium channel proteins (Probable). Interacts with KCNAB1 and KCNAB2 (By similarity). Cell membrane ; Multi-pass membrane protein The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity plasma membrane integral component of plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane axon potassium channel complex regulation of ion transmembrane transport axon terminus protein homooligomerization transmembrane transport potassium ion transmembrane transport uc033ivb.1 uc033ivb.2 uc033ivb.3 
ENSMUST00000185335.3 Gm28651 ENSMUST00000185335.3 Gm28651 (from geneSymbol) ENSMUST00000185335.1 ENSMUST00000185335.2 uc288sgy.1 uc288sgy.2 uc288sgy.3 uc288sgy.1 uc288sgy.2 uc288sgy.3 
ENSMUST00000185338.7 Gm20916 ENSMUST00000185338.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE BC049626 ENSMUST00000185338.1 ENSMUST00000185338.2 ENSMUST00000185338.3 ENSMUST00000185338.4 ENSMUST00000185338.5 ENSMUST00000185338.6 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292urj.1 uc292urj.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292urj.1 uc292urj.2 
ENSMUST00000185339.2 Gm29060 ENSMUST00000185339.2 Gm29060 (from geneSymbol) ENSMUST00000185339.1 uc292tyn.1 uc292tyn.2 uc292tyn.1 uc292tyn.2 
ENSMUST00000185340.2 Gm28897 ENSMUST00000185340.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WP44) A0A087WP44 A0A087WP44_MOUSE ENSMUST00000185340.1 Gm21760 Gm28827 Gm28897 Gm29110 Gm29564 Gm31571 uc292uso.1 uc292uso.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292uso.1 uc292uso.2 
ENSMUST00000185348.2 Gm20826 ENSMUST00000185348.2 Belongs to the SPIN/STSY family. (from UniProt J3QK38) ENSMUST00000185348.1 Gm20826 Gm21244 J3QK38 J3QK38_MOUSE uc292scb.1 uc292scb.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292scb.1 uc292scb.2 
ENSMUST00000185350.2 Gm28889 ENSMUST00000185350.2 Gm28889 (from geneSymbol) ENSMUST00000185350.1 uc292tvu.1 uc292tvu.2 uc292tvu.1 uc292tvu.2 
ENSMUST00000185351.2 1700008J07Rik ENSMUST00000185351.2 RIKEN cDNA 1700008J07 gene (from RefSeq NR_024331.1) ENSMUST00000185351.1 NR_024331 uc009jvt.1 uc009jvt.2 uc009jvt.3 uc009jvt.4 uc009jvt.1 uc009jvt.2 uc009jvt.3 uc009jvt.4 
ENSMUST00000185365.2 Gm28670 ENSMUST00000185365.2 Gm28670 (from geneSymbol) ENSMUST00000185365.1 uc292uzp.1 uc292uzp.2 uc292uzp.1 uc292uzp.2 
ENSMUST00000185378.2 Gm29322 ENSMUST00000185378.2 Gm29322 (from geneSymbol) ENSMUST00000185378.1 uc292hlm.1 uc292hlm.2 uc292hlm.1 uc292hlm.2 
ENSMUST00000185379.3 Gm29414 ENSMUST00000185379.3 Gm29414 (from geneSymbol) ENSMUST00000185379.1 ENSMUST00000185379.2 uc287gxh.1 uc287gxh.2 uc287gxh.3 uc287gxh.1 uc287gxh.2 uc287gxh.3 
ENSMUST00000185381.2 Zfp658 ENSMUST00000185381.2 Belongs to the krueppel C2H2-type zinc-finger protein family. (from UniProt A0A087WS64) A0A087WS64 A0A087WS64_MOUSE ENSMUST00000185381.1 Gm7145 uc287lbc.1 uc287lbc.2 Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleoplasm regulation of transcription, DNA-templated transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding uc287lbc.1 uc287lbc.2 
ENSMUST00000185384.7 Rbis ENSMUST00000185384.7 ribosomal biogenesis factor, transcript variant 2 (from RefSeq NM_001099674.1) ENSMUST00000185384.1 ENSMUST00000185384.2 ENSMUST00000185384.3 ENSMUST00000185384.4 ENSMUST00000185384.5 ENSMUST00000185384.6 G3UW58 NM_001099674 Q0VG62 RBIS_MOUSE uc008oqm.1 uc008oqm.2 uc008oqm.3 Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production. Associates with the pre-60S ribosomal particles. Nucleus, nucleolus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0VG62-2; Sequence=Displayed; Name=2; IsoId=Q0VG62-1; Sequence=VSP_060139; molecular_function nucleus nucleolus ribosome biogenesis uc008oqm.1 uc008oqm.2 uc008oqm.3 
ENSMUST00000185385.2 Gm29290 ENSMUST00000185385.2 Gm29290 (from geneSymbol) ENSMUST00000185385.1 uc287mrr.1 uc287mrr.2 uc287mrr.1 uc287mrr.2 
ENSMUST00000185395.2 9430002A10Rik ENSMUST00000185395.2 9430002A10Rik (from geneSymbol) AK020399 ENSMUST00000185395.1 uc292bwk.1 uc292bwk.2 uc292bwk.1 uc292bwk.2 
ENSMUST00000185402.4 5430405H02Rik ENSMUST00000185402.4 5430405H02Rik (from geneSymbol) AK017271 ENSMUST00000185402.1 ENSMUST00000185402.2 ENSMUST00000185402.3 uc290bzd.1 uc290bzd.2 uc290bzd.3 uc290bzd.4 uc290bzd.1 uc290bzd.2 uc290bzd.3 uc290bzd.4 
ENSMUST00000185406.8 Muc2 ENSMUST00000185406.8 mucin 2 (from RefSeq NM_023566.4) A0A087WSG8 ENSMUST00000185406.1 ENSMUST00000185406.2 ENSMUST00000185406.3 ENSMUST00000185406.4 ENSMUST00000185406.5 ENSMUST00000185406.6 ENSMUST00000185406.7 MUC2_MOUSE Muc2 NM_023566 Q0P637 Q80Z17 Q80Z19 Q8K0Q1 Q9CVG8 Q9Z2U5 uc291xfu.1 uc291xfu.2 Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (PubMed:18806221, PubMed:19432394, PubMed:33093110). Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine (PubMed:18806221, PubMed:19432394, PubMed:33093110). MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange (PubMed:18806221, PubMed:19432394). Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells (By similarity). Binds both Cu(2+) and its reduced form, Cu(1+), at two juxtaposed binding sites: Cu(2+), once reduced to Cu(1+) by vitamin C (ascorbate) or other dietary antioxidants, transits to the other binding site (By similarity). MUC2- bound Cu(1+) is protected from oxidation in aerobic environments, and can be released for nutritional delivery to cells (By similarity). Mucin gels store antimicrobial molecules that participate in innate immunity (PubMed:18806221, PubMed:19432394). Mucin glycoproteins also house and feed the microbiome, lubricate tissue surfaces, and may facilitate the removal of contaminants and waste products from the body (PubMed:33093110). Goblet cells synthesize two forms of MUC2 mucin that differ in branched chain O-glycosylation and the site of production in the colon: a (1) 'thick' mucus that wraps the microbiota to form fecal pellets is produced in the proximal, ascending colon (PubMed:33093110). 'Thick' mucus transits along the descending colon and is lubricated by a (2) 'thin' MUC2 mucus produced in the distal colon which adheres to the 'thick' mucus (PubMed:33093110). Homomultimer; disulfide-linked. The N- and C-terminus mediate their assembly into higher order structures to form filaments (By similarity). The CTCK domains of two polypeptides associate in the endoplasmic reticulum to generate intermolecularly disulfide-bonded dimers (By similarity). These dimers progress to the Golgi apparatus, which is a more acidic environment than the endoplasmic reticulum (By similarity). Under acidic conditions, the N-termini form non-covalent intermolecular interactions that juxtapose assemblies of the third VWD domain (VWD3) from different CTCK-linked dimers (By similarity). The VWD3 assemblies then become disulfide bonded to one another to produce long, disulfide-linked polymers that remain highly compact until secretion (By similarity). Interacts with FCGBP (PubMed:19432394). Interacts with AGR2; disulfide-linked (By similarity). Secreted te=In the intestine, secreted into the inner and outer mucus layers (PubMed:18806221, PubMed:19432394). Before secretion, mucin polymers are stored in dedicated secretory vesicles (By similarity). Highly expressed in goblet cells of the colon with lower levels in the small intestine and no expression in the stomach (at protein level). The CTCK domain mediates interchain disulfide bonds with another molecule of MUC2. O-glycosylated (PubMed:9886986). O-glycosylation is required for mucin assembly (By similarity). Goblet cells synthesize two forms of mucin that differ in branched chain O-glycosylation and the site of production in the colon (PubMed:33093110). May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria. At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway. Aberrant intestinal crypt morphology and altered cell maturation and migration (PubMed:11872843). Frequent development of adenomas in the small intestine which progress to invasive adenocarcinomas, as well as rectal tumors (PubMed:11872843). Absence of inner and outer mucus layers in the colon so that bacteria are in direct contact with the colon epithelium and enter into the cells and crypts in contrast to wild-type animals which are devoid of bacteria in the inner mucus layer (PubMed:18806221). Sequence=AAH30862.1; Type=Erroneous initiation; Evidence=; Name=Mucin database; URL="http://www.medkem.gu.se/mucinbiology/databases/"; epithelial cell development protein binding extracellular region apoptotic process negative regulation of cell proliferation maintenance of gastrointestinal epithelium negative regulation of cell migration extracellular matrix positive regulation of apoptotic process mucus layer inner mucus layer outer mucus layer uc291xfu.1 uc291xfu.2 
ENSMUST00000185407.2 Scgb2b21 ENSMUST00000185407.2 secretoglobin, family 2B, member 21 (from RefSeq NM_001310615.1) A0A087WQA9 A0A087WQA9_MOUSE Abpbg21 ENSMUST00000185407.1 NM_001310615 Scgb2b21 uc057bzq.1 uc057bzq.2 uc057bzq.3 Secreted Belongs to the secretoglobin family. molecular_function cellular_component extracellular space biological_process uc057bzq.1 uc057bzq.2 uc057bzq.3 
ENSMUST00000185424.4 A930005H10Rik ENSMUST00000185424.4 A930005H10Rik (from geneSymbol) AK020812 ENSMUST00000185424.1 ENSMUST00000185424.2 ENSMUST00000185424.3 uc008rbp.1 uc008rbp.2 uc008rbp.3 uc008rbp.4 uc008rbp.5 uc008rbp.6 uc008rbp.7 uc008rbp.1 uc008rbp.2 uc008rbp.3 uc008rbp.4 uc008rbp.5 uc008rbp.6 uc008rbp.7 
ENSMUST00000185427.7 Gm29191 ENSMUST00000185427.7 Gm29191 (from geneSymbol) DQ874391 ENSMUST00000185427.1 ENSMUST00000185427.2 ENSMUST00000185427.3 ENSMUST00000185427.4 ENSMUST00000185427.5 ENSMUST00000185427.6 uc009vhp.1 uc009vhp.2 uc009vhp.1 uc009vhp.2 
ENSMUST00000185442.2 Gm29222 ENSMUST00000185442.2 Gm29222 (from geneSymbol) ENSMUST00000185442.1 uc292ttb.1 uc292ttb.2 uc292ttb.1 uc292ttb.2 
ENSMUST00000185451.7 Gm29021 ENSMUST00000185451.7 Gm29021 (from geneSymbol) ENSMUST00000185451.1 ENSMUST00000185451.2 ENSMUST00000185451.3 ENSMUST00000185451.4 ENSMUST00000185451.5 ENSMUST00000185451.6 uc292sth.1 uc292sth.2 uc292sth.1 uc292sth.2 
ENSMUST00000185462.7 Lrit3 ENSMUST00000185462.7 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 (from RefSeq NM_001287224.2) ENSMUST00000185462.1 ENSMUST00000185462.2 ENSMUST00000185462.3 ENSMUST00000185462.4 ENSMUST00000185462.5 ENSMUST00000185462.6 LRIT3_MOUSE Lrit3 NM_001287224 W8DXL4 uc033hzp.1 uc033hzp.2 uc033hzp.3 Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells (PubMed:25997951, PubMed:26427409, PubMed:28334377). Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina (PubMed:26427409, PubMed:28334377). Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (PubMed:25997951). Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles (PubMed:28334377). May also have a role in cone synapse formation (PubMed:25997951, PubMed:28334377). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (By similarity). Could be a regulator of the FGFRs (By similarity). Cell projection, dendrite Perikaryon Endoplasmic reticulum membrane ; Single-pass type I membrane protein Note=Punctate expression at dendrite tips. Detected in the outer plexiform layer (OPL) of the retina, where it localizes to rod and cone ON-bipolar cells (at protein level). Also detected in bipolar cell bodies in the inner retinal layer (INL) (at protein level). Viable. Retinal anatomy is grossly normal, although thickness of the INL is reduced. In addition thickness of the innermost region consisting of the inner plexiform layer, ganglion cell layer and optic nerve fiber layer (IPL, GCL, NFL), is reduced. Optomotor responses in dim conditions are impaired. Electroretinography shows completely absent b-wave response under dim conditions, and milder abnormalities under bright conditions (PubMed:24598786). Abolishes ON-responses and delays OFF-responses in retinal ganglion cells (PubMed:28334377). Rod photoreceptors show normal morphology (PubMed:28334377). Cone photoreceptor synapses show morphological abnormalities including a decrease in the number of triad processes in cone pedicles in favor of diad processes, the number of flat contacts at the base of pedicle synapses are increased, deep invaginating contacts made by cone ON-bipolar cells are lost, and vacuole-like structures are present at cone synaptic terminals (PubMed:28334377). molecular_function cellular_component endoplasmic reticulum endoplasmic reticulum membrane visual perception membrane integral component of membrane dendrite regulation of fibroblast growth factor receptor signaling pathway cell projection perikaryon response to stimulus uc033hzp.1 uc033hzp.2 uc033hzp.3 
ENSMUST00000185463.2 Gm28262 ENSMUST00000185463.2 Gm28262 (from geneSymbol) ENSMUST00000185463.1 uc291xzz.1 uc291xzz.2 uc291xzz.1 uc291xzz.2 
ENSMUST00000185465.8 A830008E24Rik ENSMUST00000185465.8 A830008E24Rik (from geneSymbol) AK043564 ENSMUST00000185465.1 ENSMUST00000185465.2 ENSMUST00000185465.3 ENSMUST00000185465.4 ENSMUST00000185465.5 ENSMUST00000185465.6 ENSMUST00000185465.7 uc007dar.1 uc007dar.2 uc007dar.3 uc007dar.1 uc007dar.2 uc007dar.3 
ENSMUST00000185475.3 Vmn1r205 ENSMUST00000185475.3 vomeronasal 1 receptor 205 (from RefSeq NM_134217.1) ENSMUST00000185475.1 ENSMUST00000185475.2 NM_134217 Q8R276 Q8R276_MOUSE V1rh8 Vmn1r205 uc007psv.1 uc007psv.2 uc007psv.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc007psv.1 uc007psv.2 uc007psv.3 
ENSMUST00000185478.3 4930533D04Rik ENSMUST00000185478.3 4930533D04Rik (from geneSymbol) AK131685 ENSMUST00000185478.1 ENSMUST00000185478.2 uc009rfv.1 uc009rfv.2 uc009rfv.3 uc009rfv.1 uc009rfv.2 uc009rfv.3 
ENSMUST00000185479.2 Gm49380 ENSMUST00000185479.2 E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3. (from UniProt Q8BUH7) AK085078 ENSMUST00000185479.1 F6SS41 Q5PR90 Q8BUH7 Q8BZY8 Q99KC1 RNF26_MOUSE Rnf26 uc292glh.1 uc292glh.2 E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with INCA1. Interacts with TMEM43, ENDOD1, TMEM33 and TMED1 to form a complex capable of modulating innate immune signaling through the cGAS-STING pathway. Interacts with UBE2J1; this interaction is important for SQSTM1 ubiquitination. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BUH7-1; Sequence=Displayed; Name=2; IsoId=Q8BUH7-2; Sequence=VSP_042390, VSP_042391; endoplasmic reticulum endoplasmic reticulum membrane endosome organization membrane integral component of membrane protein ubiquitination transferase activity regulation of type I interferon production metal ion binding negative regulation of defense response to virus ubiquitin protein ligase activity protein K11-linked ubiquitination protein localization to perinuclear region of cytoplasm uc292glh.1 uc292glh.2 
ENSMUST00000185486.3 Gm28875 ENSMUST00000185486.3 Gm28875 (from geneSymbol) AK087875 ENSMUST00000185486.1 ENSMUST00000185486.2 uc288ixz.1 uc288ixz.2 uc288ixz.1 uc288ixz.2 
ENSMUST00000185500.2 Gm29285 ENSMUST00000185500.2 Gm29285 (from geneSymbol) ENSMUST00000185500.1 uc292tia.1 uc292tia.2 uc292tia.1 uc292tia.2 
ENSMUST00000185502.7 Spock1 ENSMUST00000185502.7 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1, transcript variant 1 (from RefSeq NM_009262.3) ENSMUST00000185502.1 ENSMUST00000185502.2 ENSMUST00000185502.3 ENSMUST00000185502.4 ENSMUST00000185502.5 ENSMUST00000185502.6 NM_009262 Q6DIC9 Q6DIC9_MOUSE Spock1 uc057kqf.1 uc057kqf.2 uc057kqf.3 Secreted, extracellular space, extracellular matrix Lacks conserved residue(s) required for the propagation of feature annotation. cysteine-type endopeptidase inhibitor activity calcium ion binding extracellular space metalloendopeptidase inhibitor activity negative regulation of cell-substrate adhesion negative regulation of endopeptidase activity negative regulation of neuron projection development uc057kqf.1 uc057kqf.2 uc057kqf.3 
ENSMUST00000185516.2 Gm28177 ENSMUST00000185516.2 Gm28177 (from geneSymbol) AK018544 ENSMUST00000185516.1 uc287hzm.1 uc287hzm.2 uc287hzm.1 uc287hzm.2 
ENSMUST00000185536.2 Gm28941 ENSMUST00000185536.2 Gm28941 (from geneSymbol) BC054459 ENSMUST00000185536.1 uc287jsk.1 uc287jsk.2 uc287jsk.1 uc287jsk.2 
ENSMUST00000185537.2 Gm21801 ENSMUST00000185537.2 Gm21801 (from geneSymbol) ENSMUST00000185537.1 FJ386436 uc292tfs.1 uc292tfs.2 uc292tfs.1 uc292tfs.2 
ENSMUST00000185540.3 Gm3830 ENSMUST00000185540.3 Gm3830 (from geneSymbol) AK052254 ENSMUST00000185540.1 ENSMUST00000185540.2 uc292ctd.1 uc292ctd.2 uc292ctd.3 uc292ctd.1 uc292ctd.2 uc292ctd.3 
ENSMUST00000185546.3 1700030O20Rik ENSMUST00000185546.3 1700030O20Rik (from geneSymbol) AK006570 ENSMUST00000185546.1 ENSMUST00000185546.2 uc007hch.1 uc007hch.2 uc007hch.3 uc007hch.1 uc007hch.2 uc007hch.3 
ENSMUST00000185550.7 Gm20736 ENSMUST00000185550.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WQC7) A0A087WQC7 A0A087WQC7_MOUSE BC100464 ENSMUST00000185550.1 ENSMUST00000185550.2 ENSMUST00000185550.3 ENSMUST00000185550.4 ENSMUST00000185550.5 ENSMUST00000185550.6 Gm20736 Gm21258 uc292uai.1 uc292uai.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292uai.1 uc292uai.2 
ENSMUST00000185564.2 Gm28731 ENSMUST00000185564.2 Gm28731 (from geneSymbol) ENSMUST00000185564.1 uc292iky.1 uc292iky.2 uc292iky.1 uc292iky.2 
ENSMUST00000185565.2 Gm20835 ENSMUST00000185565.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE BC100464 ENSMUST00000185565.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292tcy.1 uc292tcy.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292tcy.1 uc292tcy.2 
ENSMUST00000185575.2 Gm29564 ENSMUST00000185575.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WP44) A0A087WP44 A0A087WP44_MOUSE ENSMUST00000185575.1 Gm21760 Gm28827 Gm28897 Gm29110 Gm29564 Gm31571 uc292uqj.1 uc292uqj.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292uqj.1 uc292uqj.2 
ENSMUST00000185576.2 Gm20834 ENSMUST00000185576.2 Belongs to the SPIN/STSY family. (from UniProt J3QM72) ENSMUST00000185576.1 Gm20834 J3QM72 J3QM72_MOUSE uc292sez.1 uc292sez.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sez.1 uc292sez.2 
ENSMUST00000185581.2 Krtap20-1 ENSMUST00000185581.2 keratin associated protein 6-3 (from RefSeq NM_010674.1) A0A087WQL6 A0A087WQL6_MOUSE ENSMUST00000185581.1 Krtap6-3 NM_010674 uc289fvu.1 uc289fvu.2 Interacts with hair keratins. molecular_function cellular_component biological_process uc289fvu.1 uc289fvu.2 
ENSMUST00000185586.2 Gm28684 ENSMUST00000185586.2 Gm28684 (from geneSymbol) ENSMUST00000185586.1 uc292tmd.1 uc292tmd.2 uc292tmd.1 uc292tmd.2 
ENSMUST00000185587.2 Gm29084 ENSMUST00000185587.2 Gm29084 (from geneSymbol) BC010676 ENSMUST00000185587.1 uc287iqq.1 uc287iqq.2 uc287iqq.1 uc287iqq.2 
ENSMUST00000185588.2 Gm29473 ENSMUST00000185588.2 Gm29473 (from geneSymbol) ENSMUST00000185588.1 uc292utq.1 uc292utq.2 uc292utq.1 uc292utq.2 
ENSMUST00000185592.2 Gm28431 ENSMUST00000185592.2 Gm28431 (from geneSymbol) ENSMUST00000185592.1 uc292uib.1 uc292uib.2 uc292uib.1 uc292uib.2 
ENSMUST00000185593.7 Gm29532 ENSMUST00000185593.7 Gm29532 (from geneSymbol) ENSMUST00000185593.1 ENSMUST00000185593.2 ENSMUST00000185593.3 ENSMUST00000185593.4 ENSMUST00000185593.5 ENSMUST00000185593.6 uc292szz.1 uc292szz.2 uc292szz.1 uc292szz.2 
ENSMUST00000185595.7 Serpina3a ENSMUST00000185595.7 serine (or cysteine) peptidase inhibitor, clade A, member 3A, transcript variant 1 (from RefSeq NM_001167705.1) A0A087WQ35 ENSMUST00000185595.1 ENSMUST00000185595.2 ENSMUST00000185595.3 ENSMUST00000185595.4 ENSMUST00000185595.5 ENSMUST00000185595.6 H7BWY0 H7BWY0_MOUSE NM_001167705 Serpina3a uc007owt.1 uc007owt.2 uc007owt.3 Belongs to the serpin family. extracellular space uc007owt.1 uc007owt.2 uc007owt.3 
ENSMUST00000185603.2 Gm28278 ENSMUST00000185603.2 Gm28278 (from geneSymbol) ENSMUST00000185603.1 uc292tie.1 uc292tie.2 uc292tie.1 uc292tie.2 
ENSMUST00000185605.2 Gm29504 ENSMUST00000185605.2 Gm29504 (from geneSymbol) ENSMUST00000185605.1 uc292vab.1 uc292vab.2 uc292vab.1 uc292vab.2 
ENSMUST00000185617.2 Gm28221 ENSMUST00000185617.2 Gm28221 (from geneSymbol) ENSMUST00000185617.1 uc288xqv.1 uc288xqv.2 uc288xqv.1 uc288xqv.2 
ENSMUST00000185620.2 Gm29662 ENSMUST00000185620.2 Gm29662 (from geneSymbol) ENSMUST00000185620.1 uc292ueq.1 uc292ueq.2 uc292ueq.1 uc292ueq.2 
ENSMUST00000185623.2 ENSMUSG00000121313 ENSMUST00000185623.2 ENSMUSG00000121313 (from geneSymbol) ENSMUST00000185623.1 uc292ttv.1 uc292ttv.2 uc292ttv.1 uc292ttv.2 
ENSMUST00000185625.7 Gm29360 ENSMUST00000185625.7 Gm29360 (from geneSymbol) ENSMUST00000185625.1 ENSMUST00000185625.2 ENSMUST00000185625.3 ENSMUST00000185625.4 ENSMUST00000185625.5 ENSMUST00000185625.6 uc292tey.1 uc292tey.2 uc292tey.1 uc292tey.2 
ENSMUST00000185627.2 Gm28322 ENSMUST00000185627.2 Gm28322 (from geneSymbol) ENSMUST00000185627.1 uc287hyf.1 uc287hyf.2 uc287hyf.1 uc287hyf.2 
ENSMUST00000185630.2 Gm28407 ENSMUST00000185630.2 Gm28407 (from geneSymbol) ENSMUST00000185630.1 uc292uzc.1 uc292uzc.2 uc292uzc.1 uc292uzc.2 
ENSMUST00000185631.2 Gm29660 ENSMUST00000185631.2 Gm29660 (from geneSymbol) ENSMUST00000185631.1 uc292ues.1 uc292ues.2 uc292ues.1 uc292ues.2 
ENSMUST00000185636.2 Gm21317 ENSMUST00000185636.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE BC049626 ENSMUST00000185636.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292utm.1 uc292utm.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292utm.1 uc292utm.2 
ENSMUST00000185641.7 Atp5mc2 ENSMUST00000185641.7 ATP synthase membrane subunit c locus 2 (from RefSeq NM_026468.2) AT5G2_MOUSE Atp5g2 Atp5mc2 ENSMUST00000185641.1 ENSMUST00000185641.2 ENSMUST00000185641.3 ENSMUST00000185641.4 ENSMUST00000185641.5 ENSMUST00000185641.6 NM_026468 P56383 Q3KQM0 Q9CQ23 uc007xwr.1 uc007xwr.2 uc007xwr.3 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Interacts with DNAJC30; interaction is direct. Mitochondrion membrane; Multi-pass membrane protein. Trimethylated by ATPSCKMT at Lys-114. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Note=This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease). There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Belongs to the ATPase C chain family. mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) mitochondrion ion transport lipid binding hydrogen ion transmembrane transporter activity ATP synthesis coupled proton transport membrane integral component of membrane ligand-gated channel activity mitochondrial membrane proton-transporting two-sector ATPase complex, proton-transporting domain cation channel complex proton-transporting ATP synthase complex, coupling factor F(o) pore complex assembly proton-transporting ATP synthase activity, rotational mechanism hydrogen ion transmembrane transport uc007xwr.1 uc007xwr.2 uc007xwr.3 
ENSMUST00000185652.3 1810034E14Rik ENSMUST00000185652.3 1810034E14Rik (from geneSymbol) AK143964 ENSMUST00000185652.1 ENSMUST00000185652.2 uc288nvn.1 uc288nvn.2 uc288nvn.3 uc288nvn.1 uc288nvn.2 uc288nvn.3 
ENSMUST00000185662.7 Mir155hg ENSMUST00000185662.7 Mir155hg (from geneSymbol) AY096003 ENSMUST00000185662.1 ENSMUST00000185662.2 ENSMUST00000185662.3 ENSMUST00000185662.4 ENSMUST00000185662.5 ENSMUST00000185662.6 uc289fse.1 uc289fse.2 uc289fse.1 uc289fse.2 
ENSMUST00000185663.2 Gm28214 ENSMUST00000185663.2 Gm28214 (from geneSymbol) ENSMUST00000185663.1 uc290avx.1 uc290avx.2 uc290avx.1 uc290avx.2 
ENSMUST00000185665.7 Rgs6 ENSMUST00000185665.7 regulator of G-protein signaling 6, transcript variant 7 (from RefSeq NR_182187.1) A0A087WNZ9 A0A087WNZ9_MOUSE A0A087WRN0 ENSMUST00000185665.1 ENSMUST00000185665.2 ENSMUST00000185665.3 ENSMUST00000185665.4 ENSMUST00000185665.5 ENSMUST00000185665.6 NR_182187 Rgs6 uc057bby.1 uc057bby.2 uc057bby.3 GTPase activator activity cytosol G-protein coupled receptor signaling pathway extrinsic component of membrane intracellular signal transduction positive regulation of GTPase activity uc057bby.1 uc057bby.2 uc057bby.3 
ENSMUST00000185667.2 Gm29582 ENSMUST00000185667.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRT9) A0A087WRT9 A0A087WRT9_MOUSE AK077064 ENSMUST00000185667.1 Gm28490 Gm29582 uc292swi.1 uc292swi.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292swi.1 uc292swi.2 
ENSMUST00000185675.7 Glce ENSMUST00000185675.7 glucuronyl C5-epimerase, transcript variant 1 (from RefSeq NM_033320.5) ENSMUST00000185675.1 ENSMUST00000185675.2 ENSMUST00000185675.3 ENSMUST00000185675.4 ENSMUST00000185675.5 ENSMUST00000185675.6 GLCE_MOUSE NM_033320 Q505E6 Q99MM0 Q9EPS3 uc009qae.1 uc009qae.2 uc009qae.3 uc009qae.4 Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. Reaction=[heparosan-N-sulfate](n) = [heparan-N-sulfate](n); Xref=Rhea:RHEA:20197, Rhea:RHEA-COMP:9556, Rhea:RHEA-COMP:9557, ChEBI:CHEBI:58041, ChEBI:CHEBI:58287; EC=5.1.3.17; Evidence=; Glycan metabolism; heparan sulfate biosynthesis. Glycan metabolism; heparin biosynthesis. Homodimer (By similarity). Interacts with HS2ST1 (PubMed:11687650). Golgi apparatus membrane ; Single-pass type II membrane protein Widely expressed with highest levels in lung and lowest levels in spleen. Perinatal lethality. Pups die shortly after birth, apparently from respiratory failure. Mice show immature lung structure, lack kidneys, have abnormally small thymus and spleen, defects in inguinal lymph node development and in blood vessel formation proximal to the inguinal lymph nodes, and display important skeletal deficiencies. Mutant mice have heparan and heparin chains that are deficient in iduronic acid residues, and that therefore have altered O-sulfation patterns. Belongs to the D-glucuronyl C5-epimerase family. Golgi membrane calcium ion binding Golgi apparatus heparan sulfate proteoglycan biosynthetic process membrane integral component of membrane isomerase activity racemase and epimerase activity, acting on carbohydrates and derivatives heparin biosynthetic process protein homodimerization activity metal ion binding heparosan-N-sulfate-glucuronate 5-epimerase activity UDP-glucuronate 5'-epimerase activity uc009qae.1 uc009qae.2 uc009qae.3 uc009qae.4 
ENSMUST00000185678.2 Celrr ENSMUST00000185678.2 Celrr (from geneSymbol) AK045543 ENSMUST00000185678.1 uc287lft.1 uc287lft.2 uc287lft.1 uc287lft.2 
ENSMUST00000185679.2 Gm28590 ENSMUST00000185679.2 predicted gene 28590 (from RefSeq NR_151524.1) ENSMUST00000185679.1 NR_151524 uc287lgy.1 uc287lgy.2 uc287lgy.1 uc287lgy.2 
ENSMUST00000185683.2 Gm28082 ENSMUST00000185683.2 Gm28082 (from geneSymbol) ENSMUST00000185683.1 uc292uhf.1 uc292uhf.2 uc292uhf.1 uc292uhf.2 
ENSMUST00000185688.7 Orly ENSMUST00000185688.7 oppositely-transcribed, rearranged locus on the Y, transcript variant 1 (from RefSeq NR_164355.1) ENSMUST00000185688.1 ENSMUST00000185688.2 ENSMUST00000185688.3 ENSMUST00000185688.4 ENSMUST00000185688.5 ENSMUST00000185688.6 NR_164355 uc029yfb.1 uc029yfb.2 uc029yfb.1 uc029yfb.2 
ENSMUST00000185693.7 Snhg14 ENSMUST00000185693.7 imprinted gene in the Prader-Willi syndrome region (from RefSeq NR_015351.2) ENSMUST00000185693.1 ENSMUST00000185693.2 ENSMUST00000185693.3 ENSMUST00000185693.4 ENSMUST00000185693.5 ENSMUST00000185693.6 NR_015351 uc291qsr.1 uc291qsr.2 uc291qsr.1 uc291qsr.2 
ENSMUST00000185705.2 Gm29049 ENSMUST00000185705.2 Belongs to the SPIN/STSY family. (from UniProt A0A087WSM5) A0A087WSM5 A0A087WSM5_MOUSE ENSMUST00000185705.1 Gm29049 uc292sck.1 uc292sck.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sck.1 uc292sck.2 
ENSMUST00000185713.7 Gm21858 ENSMUST00000185713.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WQ24) A0A087WQ24 A0A087WQ24_MOUSE ENSMUST00000185713.1 ENSMUST00000185713.2 ENSMUST00000185713.3 ENSMUST00000185713.4 ENSMUST00000185713.5 ENSMUST00000185713.6 Gm21858 uc292tse.1 uc292tse.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292tse.1 uc292tse.2 
ENSMUST00000185716.2 Gm29509 ENSMUST00000185716.2 Gm29509 (from geneSymbol) ENSMUST00000185716.1 uc291ifd.1 uc291ifd.2 uc291ifd.1 uc291ifd.2 
ENSMUST00000185725.7 1700091H14Rik ENSMUST00000185725.7 RIKEN cDNA 1700091H14 gene (from RefSeq NR_073362.1) ENSMUST00000185725.1 ENSMUST00000185725.2 ENSMUST00000185725.3 ENSMUST00000185725.4 ENSMUST00000185725.5 ENSMUST00000185725.6 NR_073362 uc033gph.1 uc033gph.2 uc033gph.1 uc033gph.2 
ENSMUST00000185726.3 1700064M15Rik ENSMUST00000185726.3 1700064M15Rik (from geneSymbol) AK006884 ENSMUST00000185726.1 ENSMUST00000185726.2 uc007osa.1 uc007osa.2 uc007osa.3 uc007osa.4 uc007osa.1 uc007osa.2 uc007osa.3 uc007osa.4 
ENSMUST00000185727.2 Gm29253 ENSMUST00000185727.2 Gm29253 (from geneSymbol) AK151165 ENSMUST00000185727.1 uc287jib.1 uc287jib.2 uc287jib.1 uc287jib.2 
ENSMUST00000185729.2 Gm29071 ENSMUST00000185729.2 Gm29071 (from geneSymbol) ENSMUST00000185729.1 uc292uvq.1 uc292uvq.2 uc292uvq.1 uc292uvq.2 
ENSMUST00000185734.3 ENSMUSG00000121841 ENSMUST00000185734.3 ENSMUSG00000121841 (from geneSymbol) ENSMUST00000185734.1 ENSMUST00000185734.2 uc291iqh.1 uc291iqh.2 uc291iqh.3 uc291iqh.1 uc291iqh.2 uc291iqh.3 
ENSMUST00000185737.4 Gm28935 ENSMUST00000185737.4 Gm28935 (from geneSymbol) ENSMUST00000185737.1 ENSMUST00000185737.2 ENSMUST00000185737.3 uc289qyg.1 uc289qyg.2 uc289qyg.3 uc289qyg.4 uc289qyg.1 uc289qyg.2 uc289qyg.3 uc289qyg.4 
ENSMUST00000185738.2 Gm29588 ENSMUST00000185738.2 Gm29588 (from geneSymbol) ENSMUST00000185738.1 uc291dtx.1 uc291dtx.2 uc291dtx.1 uc291dtx.2 
ENSMUST00000185741.2 Gm29513 ENSMUST00000185741.2 Gm29513 (from geneSymbol) ENSMUST00000185741.1 uc288emt.1 uc288emt.2 uc288emt.1 uc288emt.2 
ENSMUST00000185752.2 Elf3 ENSMUST00000185752.2 E74-like factor 3, transcript variant 2 (from RefSeq NM_007921.3) B7ZNQ9 B9EI01 ELF3_MOUSE ENSMUST00000185752.1 Elf3 Ert Esx Jen NM_007921 O35275 Q3UPW2 uc007csw.1 uc007csw.2 uc007csw.3 uc007csw.4 Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter (By similarity). Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity (By similarity). Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway (By similarity). May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development. Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3 (By similarity). Interacts with ZNF768 (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q3UPW2-1; Sequence=Displayed; Name=2 ; IsoId=Q3UPW2-2; Sequence=VSP_052434; Expressed in small intestine, colon, lung, kidney and uterus. Also expressed in the corneal epithelium and conjunctiva of the developing and adult eye. Not detected in liver, spleen, thymus, brain, heart, skeletal muscle or ovary. Expression increases progressively from 7 dpc and is detectable in virgin mammary glands, then shows little if any change during pregnancy and declines to barely detectable levels after 3 days of lactation. Detected from 13.5 dpc in conjunctiva epithelium. In cornea, a weak signal is detected at 16.5 dpc and persists throughout the later stages of development. Expression in HC11 cells from midpregnant mouse mammary epithelium increases upon reaching lactogenic competency, and is down- regulated upon exposure to lactogenic hormones that induce milk protein (Beta-casein) expression. Up-regulated upon differentiation in corneal epithelium. Mice show about 30% fetal lethality at around 11.5 dpc. Approximately 70% of the mutant progeny are born and display severe alterations in tissue architecture in the small intestine. Elf3- deficient enterocytes express markedly reduced levels of TGFBR2. Belongs to the ETS family. RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding blastocyst development DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity nucleus nucleoplasm cytoplasm Golgi apparatus cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response multicellular organism development anatomical structure morphogenesis cell differentiation extracellular matrix organization epithelial cell differentiation sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter mammary gland involution uc007csw.1 uc007csw.2 uc007csw.3 uc007csw.4 
ENSMUST00000185755.2 Btbd35f16 ENSMUST00000185755.2 BTB domain containing 35, family member 16 (from RefSeq NM_001243011.1) A0A087WSN2 A0A087WSN2_MOUSE Btbd35f16 ENSMUST00000185755.1 Gm3701 NM_001243011 uc009skm.1 uc009skm.2 uc009skm.3 molecular_function cellular_component biological_process uc009skm.1 uc009skm.2 uc009skm.3 
ENSMUST00000185776.7 Gm21095 ENSMUST00000185776.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WR14) A0A087WR14 A0A087WR14_MOUSE BC049626 ENSMUST00000185776.1 ENSMUST00000185776.2 ENSMUST00000185776.3 ENSMUST00000185776.4 ENSMUST00000185776.5 ENSMUST00000185776.6 Gm21095 uc029ygm.1 uc029ygm.2 uc029ygm.3 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc029ygm.1 uc029ygm.2 uc029ygm.3 
ENSMUST00000185784.2 Gm29077 ENSMUST00000185784.2 Gm29077 (from geneSymbol) ENSMUST00000185784.1 uc292tar.1 uc292tar.2 uc292tar.1 uc292tar.2 
ENSMUST00000185786.2 Gm29235 ENSMUST00000185786.2 Gm29235 (from geneSymbol) ENSMUST00000185786.1 uc289ysr.1 uc289ysr.2 uc289ysr.1 uc289ysr.2 
ENSMUST00000185801.2 Gm29353 ENSMUST00000185801.2 Gm29353 (from geneSymbol) ENSMUST00000185801.1 uc292rzn.1 uc292rzn.2 uc292rzn.1 uc292rzn.2 
ENSMUST00000185808.2 Gm29123 ENSMUST00000185808.2 Gm29123 (from geneSymbol) AK040544 ENSMUST00000185808.1 uc292koh.1 uc292koh.2 uc292koh.1 uc292koh.2 
ENSMUST00000185822.9 1700086L19Rik ENSMUST00000185822.9 1700086L19Rik (from geneSymbol) AK007020 ENSMUST00000185822.1 ENSMUST00000185822.2 ENSMUST00000185822.3 ENSMUST00000185822.4 ENSMUST00000185822.5 ENSMUST00000185822.6 ENSMUST00000185822.7 ENSMUST00000185822.8 uc007nwx.1 uc007nwx.2 uc007nwx.3 uc007nwx.4 uc007nwx.5 uc007nwx.6 uc007nwx.1 uc007nwx.2 uc007nwx.3 uc007nwx.4 uc007nwx.5 uc007nwx.6 
ENSMUST00000185828.2 Gm28235 ENSMUST00000185828.2 Gm28235 (from geneSymbol) ENSMUST00000185828.1 uc292tpn.1 uc292tpn.2 uc292tpn.1 uc292tpn.2 
ENSMUST00000185843.2 Gm29421 ENSMUST00000185843.2 Gm29421 (from geneSymbol) ENSMUST00000185843.1 uc292tyg.1 uc292tyg.2 uc292tyg.1 uc292tyg.2 
ENSMUST00000185844.7 Gm29315 ENSMUST00000185844.7 Gm29315 (from geneSymbol) DQ874392 ENSMUST00000185844.1 ENSMUST00000185844.2 ENSMUST00000185844.3 ENSMUST00000185844.4 ENSMUST00000185844.5 ENSMUST00000185844.6 uc292svs.1 uc292svs.2 uc292svs.1 uc292svs.2 
ENSMUST00000185852.7 Msh3 ENSMUST00000185852.7 mutS homolog 3, transcript variant 1 (from RefSeq NM_010829.3) A0A087WQ16 A0A087WQ16_MOUSE ENSMUST00000185852.1 ENSMUST00000185852.2 ENSMUST00000185852.3 ENSMUST00000185852.4 ENSMUST00000185852.5 ENSMUST00000185852.6 Msh3 NM_010829 uc033gmq.1 uc033gmq.2 uc033gmq.3 uc033gmq.4 Component of the post-replicative DNA mismatch repair system (MMR). Belongs to the DNA mismatch repair MutS family. MSH3 subfamily. nucleotide binding DNA binding single-stranded DNA binding ATP binding nucleus DNA repair mismatch repair cellular response to DNA damage stimulus enzyme binding mismatched DNA binding dinucleotide insertion or deletion binding single guanine insertion binding dinucleotide repeat insertion binding MutSbeta complex maintenance of DNA repeat elements negative regulation of DNA recombination positive regulation of helicase activity uc033gmq.1 uc033gmq.2 uc033gmq.3 uc033gmq.4 
ENSMUST00000185862.2 Gm29220 ENSMUST00000185862.2 Gm29220 (from geneSymbol) ENSMUST00000185862.1 uc292ttd.1 uc292ttd.2 uc292ttd.1 uc292ttd.2 
ENSMUST00000185880.4 1810041H14Rik ENSMUST00000185880.4 1810041H14Rik (from geneSymbol) AK019031 ENSMUST00000185880.1 ENSMUST00000185880.2 ENSMUST00000185880.3 uc007van.1 uc007van.2 uc007van.3 uc007van.4 uc007van.5 uc007van.6 uc007van.7 uc007van.1 uc007van.2 uc007van.3 uc007van.4 uc007van.5 uc007van.6 uc007van.7 
ENSMUST00000185888.2 Gm28791 ENSMUST00000185888.2 Gm28791 (from geneSymbol) ENSMUST00000185888.1 LF192921 uc287mpi.1 uc287mpi.2 uc287mpi.1 uc287mpi.2 
ENSMUST00000185889.7 Gm28619 ENSMUST00000185889.7 Gm28619 (from geneSymbol) ENSMUST00000185889.1 ENSMUST00000185889.2 ENSMUST00000185889.3 ENSMUST00000185889.4 ENSMUST00000185889.5 ENSMUST00000185889.6 uc292tgb.1 uc292tgb.2 uc292tgb.1 uc292tgb.2 
ENSMUST00000185892.7 ENSMUSG00000121329 ENSMUST00000185892.7 ENSMUSG00000121329 (from geneSymbol) ENSMUST00000185892.1 ENSMUST00000185892.2 ENSMUST00000185892.3 ENSMUST00000185892.4 ENSMUST00000185892.5 ENSMUST00000185892.6 uc292ubu.1 uc292ubu.2 uc292ubu.1 uc292ubu.2 
ENSMUST00000185893.2 Fhl2 ENSMUST00000185893.2 four and a half LIM domains 2, transcript variant 2 (from RefSeq NM_001289533.2) ENSMUST00000185893.1 Fhl2 NM_001289533 Q543D7 Q543D7_MOUSE uc007avl.1 uc007avl.2 uc007avl.3 uc007avl.4 This gene encodes a member of the four-and-a-half-LIM-only protein family. The encoded protein functions as a regulator in numerous signaling pathways and cellular processes in development and cellular differentiation, including development and maintenance of the cardiovascular system and striated muscles. This gene also plays a role in bone formation and regulates and bone mineral content and bone mineral density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Z disc M band metal ion binding negative regulation of calcineurin-NFAT signaling cascade uc007avl.1 uc007avl.2 uc007avl.3 uc007avl.4 
ENSMUST00000185898.2 Gm29380 ENSMUST00000185898.2 Gm29380 (from geneSymbol) ENSMUST00000185898.1 uc292ucf.1 uc292ucf.2 uc292ucf.1 uc292ucf.2 
ENSMUST00000185900.2 Gm29061 ENSMUST00000185900.2 Gm29061 (from geneSymbol) ENSMUST00000185900.1 uc292tyo.1 uc292tyo.2 uc292tyo.1 uc292tyo.2 
ENSMUST00000185914.2 Gm5157 ENSMUST00000185914.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; (from UniProt A0A087WRH8) A0A087WRH8 A0A087WRH8_MOUSE ENSMUST00000185914.1 Gm5157 uc291mom.1 uc291mom.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. nucleotide binding microtubule cytoskeleton organization protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm protein phosphorylation intracellular signal transduction tau-protein kinase activity uc291mom.1 uc291mom.2 
ENSMUST00000185917.2 ENSMUSG00000121668 ENSMUST00000185917.2 ENSMUSG00000121668 (from geneSymbol) AK005601 ENSMUST00000185917.1 uc292gcz.1 uc292gcz.2 uc292gcz.1 uc292gcz.2 
ENSMUST00000185924.2 Gm28553 ENSMUST00000185924.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK3) A0A087WRK3 A0A087WRK3_MOUSE ENSMUST00000185924.1 Gm20817 Gm21173 Gm21497 Gm28553 uc292tll.1 uc292tll.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292tll.1 uc292tll.2 
ENSMUST00000185926.2 Gm21778 ENSMUST00000185926.2 Belongs to the SPIN/STSY family. (from UniProt A0A087WNP8) A0A087WNP8 A0A087WNP8_MOUSE ENSMUST00000185926.1 Gm21778 uc292saj.1 uc292saj.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292saj.1 uc292saj.2 
ENSMUST00000185931.7 1600010M07Rik ENSMUST00000185931.7 1600010M07Rik (from geneSymbol) AK005418 ENSMUST00000185931.1 ENSMUST00000185931.2 ENSMUST00000185931.3 ENSMUST00000185931.4 ENSMUST00000185931.5 ENSMUST00000185931.6 uc291ukg.1 uc291ukg.2 uc291ukg.1 uc291ukg.2 
ENSMUST00000185941.7 Gm28208 ENSMUST00000185941.7 Gm28208 (from geneSymbol) ENSMUST00000185941.1 ENSMUST00000185941.2 ENSMUST00000185941.3 ENSMUST00000185941.4 ENSMUST00000185941.5 ENSMUST00000185941.6 uc292tsu.1 uc292tsu.2 uc292tsu.1 uc292tsu.2 
ENSMUST00000185960.2 9330154J02Rik ENSMUST00000185960.2 9330154J02Rik (from geneSymbol) AK034076 ENSMUST00000185960.1 uc057mab.1 uc057mab.2 uc057mab.3 uc057mab.1 uc057mab.2 uc057mab.3 
ENSMUST00000185962.2 Gm8739 ENSMUST00000185962.2 Gm8739 (from geneSymbol) ENSMUST00000185962.1 uc288mtm.1 uc288mtm.2 uc288mtm.1 uc288mtm.2 
ENSMUST00000185974.8 1700008K24Rik ENSMUST00000185974.8 1700008K24Rik (from geneSymbol) AK005780 ENSMUST00000185974.1 ENSMUST00000185974.2 ENSMUST00000185974.3 ENSMUST00000185974.4 ENSMUST00000185974.5 ENSMUST00000185974.6 ENSMUST00000185974.7 uc008cye.1 uc008cye.2 uc008cye.3 uc008cye.4 uc008cye.5 uc008cye.1 uc008cye.2 uc008cye.3 uc008cye.4 uc008cye.5 
ENSMUST00000185976.2 Gm28312 ENSMUST00000185976.2 Gm28312 (from geneSymbol) ENSMUST00000185976.1 uc292thn.1 uc292thn.2 uc292thn.1 uc292thn.2 
ENSMUST00000185979.2 Gm29502 ENSMUST00000185979.2 Gm29502 (from geneSymbol) AK140001 ENSMUST00000185979.1 uc288ppb.1 uc288ppb.2 uc288ppb.1 uc288ppb.2 
ENSMUST00000185980.2 Gm28782 ENSMUST00000185980.2 Gm28782 (from geneSymbol) ENSMUST00000185980.1 uc287hrr.1 uc287hrr.2 uc287hrr.1 uc287hrr.2 
ENSMUST00000185991.2 Gm29113 ENSMUST00000185991.2 Gm29113 (from geneSymbol) ENSMUST00000185991.1 uc287iyx.1 uc287iyx.2 uc287iyx.1 uc287iyx.2 
ENSMUST00000185992.2 Gm29500 ENSMUST00000185992.2 Gm29500 (from geneSymbol) ENSMUST00000185992.1 uc287nhi.1 uc287nhi.2 uc287nhi.1 uc287nhi.2 
ENSMUST00000185995.2 Gm28760 ENSMUST00000185995.2 Gm28760 (from geneSymbol) ENSMUST00000185995.1 LF203987 uc288ndp.1 uc288ndp.2 uc288ndp.1 uc288ndp.2 
ENSMUST00000186004.2 Gm20908 ENSMUST00000186004.2 X-linked lymphocyte-regulated protein PM1-like (from RefSeq NM_001378759.1) A0A087WRK1 A0A087WRK1_MOUSE ENSMUST00000186004.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 NM_001378759 Sly uc292tzj.1 uc292tzj.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292tzj.1 uc292tzj.2 
ENSMUST00000186010.8 Gm4131 ENSMUST00000186010.8 Gm4131 (from geneSymbol) A0A140LJ24 A0A140LJ24_MOUSE ENSMUST00000186010.1 ENSMUST00000186010.2 ENSMUST00000186010.3 ENSMUST00000186010.4 ENSMUST00000186010.5 ENSMUST00000186010.6 ENSMUST00000186010.7 Gm4131 uc288vbq.1 uc288vbq.2 molecular_function cellular_component biological_process uc288vbq.1 uc288vbq.2 
ENSMUST00000186013.2 Gm28679 ENSMUST00000186013.2 Gm28679 (from geneSymbol) ENSMUST00000186013.1 uc292tmj.1 uc292tmj.2 uc292tmj.1 uc292tmj.2 
ENSMUST00000186015.2 Gm28965 ENSMUST00000186015.2 Gm28965 (from geneSymbol) ENSMUST00000186015.1 uc292ttt.1 uc292ttt.2 uc292ttt.1 uc292ttt.2 
ENSMUST00000186017.7 Nek7 ENSMUST00000186017.7 NIMA (never in mitosis gene a)-related expressed kinase 7, transcript variant 1 (from RefSeq NM_021605.5) ENSMUST00000186017.1 ENSMUST00000186017.2 ENSMUST00000186017.3 ENSMUST00000186017.4 ENSMUST00000186017.5 ENSMUST00000186017.6 NEK7_MOUSE NM_021605 Nek7 Q3UEV7 Q9ES74 uc007cvn.1 uc007cvn.2 uc007cvn.3 uc007cvn.4 Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:20473324). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:20473324). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity). Phosphorylates RPS6KB1 (By similarity). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (PubMed:26642356, PubMed:26814970). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (PubMed:26553871, PubMed:26642356, PubMed:26814970). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (PubMed:26642356, PubMed:26814970). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.34; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.34; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-97. Monomer (By similarity). Interacts with NEK9; interaction takes place during mitosis; it relieves NEK7 autoinhibition and prevents interaction with NLRP3 (By similarity). Interacts with ANKS3; this interaction alters the subcellular distribution of NEK7 by preventing its nuclear translocation (PubMed:26188091). Interacts (via N-terminus) with NLRP3 (via LRR repeat domain); the interaction is required for the formation of the complex NLRP3:PYCARD, oligomerization of PYCARD and activation of CASP1 (PubMed:26553871, PubMed:26814970, PubMed:26642356). Q9ES74; Q8R4B8: Nlrp3; NbExp=2; IntAct=EBI-16193749, EBI-6910832; Q9ES74; Q96P20: NLRP3; Xeno; NbExp=2; IntAct=EBI-16193749, EBI-6253230; Nucleus Cytoplasm Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Present at centrosome throughout the cell cycle (By similarity). Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (By similarity). Interaction with ANKS3 prevents its translocation to the nucleus (PubMed:26188091). Displays an autoinhibited conformation: Tyr-97 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9. The NTE (N-terminal extension) motif is a structural component of the catalytic domain and thus contributes to activity. Phosphorylation at Ser-195 required for its activation. Mutant mice are viable but are born at sub- Mendelian ratios. They further suffer from severe growth retardation, infertility, abnormal gait and slight paralysis of the limbs. In an experimental autoimmune encephalitis (EAE) model, mutant mice exhibited reduced disease severity relative to wild-type mice, as well as reduced recruitment of lymphocytes, monocytes/microglia, and NK cells to the spinal cord. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. nucleotide binding spindle pole protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm microtubule organizing center cytoskeleton protein phosphorylation kinase activity phosphorylation transferase activity positive regulation of telomere maintenance via telomerase metal ion binding positive regulation of telomerase activity positive regulation of telomere capping uc007cvn.1 uc007cvn.2 uc007cvn.3 uc007cvn.4 
ENSMUST00000186020.2 Gm29108 ENSMUST00000186020.2 Gm29108 (from geneSymbol) ENSMUST00000186020.1 uc292unh.1 uc292unh.2 uc292unh.1 uc292unh.2 
ENSMUST00000186031.2 Scgb1b11 ENSMUST00000186031.2 Secreted (from UniProt A0A087WQJ0) A0A087WQJ0 A0A087WQJ0_MOUSE Abpa11_a18 ENSMUST00000186031.1 Scgb1b11 Scgb1b18 uc291ogf.1 uc291ogf.2 Secreted steroid binding extracellular region uc291ogf.1 uc291ogf.2 
ENSMUST00000186034.2 Gm28333 ENSMUST00000186034.2 Gm28333 (from geneSymbol) ENSMUST00000186034.1 uc292tcn.1 uc292tcn.2 uc292tcn.1 uc292tcn.2 
ENSMUST00000186035.2 Ssty1 ENSMUST00000186035.2 spermiogenesis specific transcript on the Y 1 (from RefSeq NM_009220.2) ENSMUST00000186035.1 Gm21454 J3QPX2 J3QPX2_MOUSE NM_009220 Ssty1 uc057mcu.1 uc057mcu.2 uc057mcu.3 Belongs to the SPIN/STSY family. gamete generation uc057mcu.1 uc057mcu.2 uc057mcu.3 
ENSMUST00000186047.7 Rbmyf6 ENSMUST00000186047.7 RNA binding motif protein Y-linked family member 6 (from RefSeq NM_001270514.1) ENSMUST00000186047.1 ENSMUST00000186047.2 ENSMUST00000186047.3 ENSMUST00000186047.4 ENSMUST00000186047.5 ENSMUST00000186047.6 Gm21693 J3QK27 J3QK27_MOUSE NM_001270514 Rbmyf6 uc033jvq.1 uc033jvq.2 uc033jvq.3 Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. nucleic acid binding RNA binding nucleus spliceosomal complex positive regulation of mRNA splicing, via spliceosome ribonucleoprotein complex uc033jvq.1 uc033jvq.2 uc033jvq.3 
ENSMUST00000186048.3 1700003I22Rik ENSMUST00000186048.3 1700003I22Rik (from geneSymbol) AK005643 ENSMUST00000186048.1 ENSMUST00000186048.2 uc007baq.1 uc007baq.2 uc007baq.3 uc007baq.1 uc007baq.2 uc007baq.3 
ENSMUST00000186060.2 Gm26791 ENSMUST00000186060.2 RIKEN cDNA 1700044C05 gene (from RefSeq NR_045624.1) ENSMUST00000186060.1 NR_045624 uc029snb.1 uc029snb.2 uc029snb.3 uc029snb.1 uc029snb.2 uc029snb.3 
ENSMUST00000186065.2 Gm28887 ENSMUST00000186065.2 Gm28887 (from geneSymbol) ENSMUST00000186065.1 uc292tiq.1 uc292tiq.2 uc292tiq.1 uc292tiq.2 
ENSMUST00000186071.2 ENSMUSG00000121324 ENSMUST00000186071.2 ENSMUSG00000121324 (from geneSymbol) ENSMUST00000186071.1 uc292tzq.1 uc292tzq.2 uc292tzq.1 uc292tzq.2 
ENSMUST00000186073.7 Gm10619 ENSMUST00000186073.7 Gm10619 (from geneSymbol) AK030117 ENSMUST00000186073.1 ENSMUST00000186073.2 ENSMUST00000186073.3 ENSMUST00000186073.4 ENSMUST00000186073.5 ENSMUST00000186073.6 uc009hrh.1 uc009hrh.2 uc009hrh.1 uc009hrh.2 
ENSMUST00000186074.7 Gm29248 ENSMUST00000186074.7 Gm29248 (from geneSymbol) ENSMUST00000186074.1 ENSMUST00000186074.2 ENSMUST00000186074.3 ENSMUST00000186074.4 ENSMUST00000186074.5 ENSMUST00000186074.6 uc292tpz.1 uc292tpz.2 uc292tpz.1 uc292tpz.2 
ENSMUST00000186083.7 Gm29581 ENSMUST00000186083.7 Gm29581 (from geneSymbol) ENSMUST00000186083.1 ENSMUST00000186083.2 ENSMUST00000186083.3 ENSMUST00000186083.4 ENSMUST00000186083.5 ENSMUST00000186083.6 uc292swl.1 uc292swl.2 uc292swl.1 uc292swl.2 
ENSMUST00000186092.2 Gm29221 ENSMUST00000186092.2 Gm29221 (from geneSymbol) ENSMUST00000186092.1 uc292ttc.1 uc292ttc.2 uc292ttc.1 uc292ttc.2 
ENSMUST00000186098.7 4933400F21Rik ENSMUST00000186098.7 4933400F21Rik (from geneSymbol) AK016229 ENSMUST00000186098.1 ENSMUST00000186098.2 ENSMUST00000186098.3 ENSMUST00000186098.4 ENSMUST00000186098.5 ENSMUST00000186098.6 uc287khb.1 uc287khb.2 uc287khb.1 uc287khb.2 
ENSMUST00000186104.2 Gm29098 ENSMUST00000186104.2 Gm29098 (from geneSymbol) ENSMUST00000186104.1 uc292tkn.1 uc292tkn.2 uc292tkn.1 uc292tkn.2 
ENSMUST00000186110.3 Gm21409 ENSMUST00000186110.3 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE ENSMUST00000186110.1 ENSMUST00000186110.2 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292uvm.1 uc292uvm.2 uc292uvm.3 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292uvm.1 uc292uvm.2 uc292uvm.3 
ENSMUST00000186112.2 Gm28422 ENSMUST00000186112.2 Gm28422 (from geneSymbol) ENSMUST00000186112.1 uc292urh.1 uc292urh.2 uc292urh.1 uc292urh.2 
ENSMUST00000186118.2 Gm28664 ENSMUST00000186118.2 Gm28664 (from geneSymbol) ENSMUST00000186118.1 uc292uqm.1 uc292uqm.2 uc292uqm.1 uc292uqm.2 
ENSMUST00000186123.2 Gm28758 ENSMUST00000186123.2 Gm28758 (from geneSymbol) ENSMUST00000186123.1 uc292uvp.1 uc292uvp.2 uc292uvp.1 uc292uvp.2 
ENSMUST00000186132.2 Gm29611 ENSMUST00000186132.2 Gm29611 (from geneSymbol) BC031920 ENSMUST00000186132.1 uc287jot.1 uc287jot.2 uc287jot.1 uc287jot.2 
ENSMUST00000186133.2 Gm29501 ENSMUST00000186133.2 Gm29501 (from geneSymbol) ENSMUST00000186133.1 uc288pkm.1 uc288pkm.2 uc288pkm.1 uc288pkm.2 
ENSMUST00000186137.8 Gm50605 ENSMUST00000186137.8 Gm50605 (from geneSymbol) AK043174 ENSMUST00000186137.1 ENSMUST00000186137.2 ENSMUST00000186137.3 ENSMUST00000186137.4 ENSMUST00000186137.5 ENSMUST00000186137.6 ENSMUST00000186137.7 uc007chz.1 uc007chz.2 uc007chz.3 uc007chz.1 uc007chz.2 uc007chz.3 
ENSMUST00000186140.7 Rbmyf9 ENSMUST00000186140.7 RNA binding motif protein Y-linked family member 9 (from RefSeq NM_001270512.1) E9Q2F9 ENSMUST00000186140.1 ENSMUST00000186140.2 ENSMUST00000186140.3 ENSMUST00000186140.4 ENSMUST00000186140.5 ENSMUST00000186140.6 Gm3376 NM_001270512 Q60990 RBY1B_MOUSE Rbm Rbmy1b uc012hsd.1 uc012hsd.2 uc012hsd.3 uc012hsd.4 RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. Nucleus Testis-specific. Only expressed in spermatogonia and early spermatocytes, suggesting that expression is inactivated in the XY body during meiosis. The RBMY1 proteins are encoded by repeated regions of the Y chromosome. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. Overexpression of Rbmy proteins in mice carrying the Y(d1) deletion that removes most of the multi-copy Rbmy gene cluster does not have any effect and fails to reduce the frequency of abnormal sperm. These results raize the question of the role of Rbmy proteins in sperm development. nucleic acid binding RNA binding nucleus spliceosomal complex mRNA processing RNA splicing positive regulation of mRNA splicing, via spliceosome ribonucleoprotein complex uc012hsd.1 uc012hsd.2 uc012hsd.3 uc012hsd.4 
ENSMUST00000186143.2 Gm28579 ENSMUST00000186143.2 Gm28579 (from geneSymbol) ENSMUST00000186143.1 uc292qgl.1 uc292qgl.2 uc292qgl.1 uc292qgl.2 
ENSMUST00000186146.2 Gm28215 ENSMUST00000186146.2 Gm28215 (from geneSymbol) ENSMUST00000186146.1 uc292gjz.1 uc292gjz.2 uc292gjz.1 uc292gjz.2 
ENSMUST00000186147.7 2310069B03Rik ENSMUST00000186147.7 RIKEN cDNA 2310069B03 gene (from RefSeq NR_040520.1) ENSMUST00000186147.1 ENSMUST00000186147.2 ENSMUST00000186147.3 ENSMUST00000186147.4 ENSMUST00000186147.5 ENSMUST00000186147.6 NR_040520 uc029vwu.1 uc029vwu.2 uc029vwu.3 uc029vwu.1 uc029vwu.2 uc029vwu.3 
ENSMUST00000186151.7 Gm28296 ENSMUST00000186151.7 Gm28296 (from geneSymbol) DQ874392 ENSMUST00000186151.1 ENSMUST00000186151.2 ENSMUST00000186151.3 ENSMUST00000186151.4 ENSMUST00000186151.5 ENSMUST00000186151.6 uc292sxu.1 uc292sxu.2 uc292sxu.1 uc292sxu.2 
ENSMUST00000186153.2 Gm29537 ENSMUST00000186153.2 Gm29537 (from geneSymbol) ENSMUST00000186153.1 uc292the.1 uc292the.2 uc292the.1 uc292the.2 
ENSMUST00000186154.7 Cd22 ENSMUST00000186154.7 Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. (from UniProt P35329) CD22_MOUSE Cd22 ENSMUST00000186154.1 ENSMUST00000186154.2 ENSMUST00000186154.3 ENSMUST00000186154.4 ENSMUST00000186154.5 ENSMUST00000186154.6 L02844 Lyb-8 P35329 Q3UP36 Q9JHL2 Q9JJX9 Q9JJY0 Q9JJY1 Q9R056 Q9R094 Q9WU51 Siglec2 uc012fhy.1 uc012fhy.2 uc012fhy.3 Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Interacts with LYN, SYK, PIK3R1/PIK3R2, PLCG1, SHC1, INPP5D and GRB2 upon phosphorylation. May form a complex with INPP5D/SHIP, GRB2 and SHC1. Interacts with PTPN6/SHP-1 upon phosphorylation (By similarity). P35329; Q60631: Grb2; NbExp=4; IntAct=EBI-300059, EBI-1688; P35329; P29351: Ptpn6; NbExp=5; IntAct=EBI-300059, EBI-2620699; Cell membrane; Single-pass type I membrane protein. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CD22-beta; IsoId=P35329-1; Sequence=Displayed; Name=2; IsoId=P35329-2; Sequence=VSP_002532; Name=3; IsoId=P35329-3; Sequence=VSP_002533; B-lymphocytes. Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Phosphorylated on tyrosine residues by LYN. Phosphorylation of Tyr-783 and Tyr-843 are involved in binding to SYK. Phosphorylation of Tyr-828 is involved in binding to GRB2. Phosphorylation of Tyr-863 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Name=Functional Glycomics Gateway - Glycan Binding; Note=Siglec-2; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Itlect_194"; protein binding early endosome plasma membrane integral component of plasma membrane cell adhesion cell surface receptor signaling pathway external side of plasma membrane cell surface coreceptor activity membrane integral component of membrane protein phosphatase binding regulation of endocytosis carbohydrate binding regulation of B cell proliferation neuronal cell body membrane sialic acid binding B cell activation CD4 receptor binding regulation of immune response negative regulation of calcium-mediated signaling negative regulation of B cell receptor signaling pathway negative regulation of immunoglobulin secretion recycling endosome uc012fhy.1 uc012fhy.2 uc012fhy.3 
ENSMUST00000186156.7 BC034090 ENSMUST00000186156.7 cDNA sequence BC034090 (from RefSeq NM_001370865.1) A0A087WP46 A0A087WP46_MOUSE BC034090 ENSMUST00000186156.1 ENSMUST00000186156.2 ENSMUST00000186156.3 ENSMUST00000186156.4 ENSMUST00000186156.5 ENSMUST00000186156.6 NM_001370865 uc287mst.1 uc287mst.2 protein kinase C binding nucleus cell cortex centrosome cycle establishment or maintenance of cell polarity apical plasma membrane Rho GTPase binding regulation of cellular localization uc287mst.1 uc287mst.2 
ENSMUST00000186159.2 Gm28529 ENSMUST00000186159.2 Gm28529 (from geneSymbol) ENSMUST00000186159.1 uc289ntk.1 uc289ntk.2 uc289ntk.1 uc289ntk.2 
ENSMUST00000186162.2 Gm29418 ENSMUST00000186162.2 Gm29418 (from geneSymbol) ENSMUST00000186162.1 uc289nhe.1 uc289nhe.2 uc289nhe.1 uc289nhe.2 
ENSMUST00000186169.2 Sphkos ENSMUST00000186169.2 Sphkos (from geneSymbol) ENSMUST00000186169.1 uc288dtd.1 uc288dtd.2 uc288dtd.1 uc288dtd.2 
ENSMUST00000186194.2 Gm28998 ENSMUST00000186194.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRP6) A0A087WRP6 A0A087WRP6_MOUSE ENSMUST00000186194.1 Gm28576 Gm28998 uc292sbr.1 uc292sbr.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292sbr.1 uc292sbr.2 
ENSMUST00000186196.2 ENSMUSG00000121750 ENSMUST00000186196.2 ENSMUSG00000121750 (from geneSymbol) AK005701 ENSMUST00000186196.1 uc289dzw.1 uc289dzw.2 uc289dzw.1 uc289dzw.2 
ENSMUST00000186197.5 Alyreffm4 ENSMUST00000186197.5 predicted gene 4301 (from RefSeq NM_001166637.1) ENSMUST00000186197.1 ENSMUST00000186197.2 ENSMUST00000186197.3 ENSMUST00000186197.4 Gm4301 Gm4308 Gm4312 K9J7E2 K9J7E2_MOUSE NM_001166637 uc011xml.1 uc011xml.2 uc011xml.3 molecular_function nucleic acid binding RNA binding cellular_component biological_process uc011xml.1 uc011xml.2 uc011xml.3 
ENSMUST00000186199.2 Gm29213 ENSMUST00000186199.2 Gm29213 (from geneSymbol) ENSMUST00000186199.1 FJ386436 uc292tju.1 uc292tju.2 uc292tju.1 uc292tju.2 
ENSMUST00000186205.3 M5C1000I18Rik ENSMUST00000186205.3 M5C1000I18Rik (from geneSymbol) AK046216 ENSMUST00000186205.1 ENSMUST00000186205.2 uc292ijv.1 uc292ijv.2 uc292ijv.3 uc292ijv.1 uc292ijv.2 uc292ijv.3 
ENSMUST00000186207.7 Fbxl19 ENSMUST00000186207.7 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization (PubMed:28453857, PubMed:29809150). Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner. Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration. Mediates also ubiquitination and degradation of IL-33- induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis (PubMed:22660580). Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:28453857, PubMed:29809150). Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation (PubMed:29809150). In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination (PubMed:28453857). (from UniProt Q6PB97) AK028405 ENSMUST00000186207.1 ENSMUST00000186207.2 ENSMUST00000186207.3 ENSMUST00000186207.4 ENSMUST00000186207.5 ENSMUST00000186207.6 FXL19_MOUSE Q6PB97 Q7TSH0 Q8BIB4 uc291vxi.1 uc291vxi.2 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization (PubMed:28453857, PubMed:29809150). Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner. Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration. Mediates also ubiquitination and degradation of IL-33- induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis (PubMed:22660580). Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:28453857, PubMed:29809150). Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation (PubMed:29809150). In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination (PubMed:28453857). Directly interacts with SKP1 and CUL1. Interacts with RNF20 (PubMed:28453857). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PB97-1; Sequence=Displayed; Name=2; IsoId=Q6PB97-2; Sequence=VSP_013017; Name=3; IsoId=Q6PB97-3; Sequence=VSP_013016, VSP_013017; The CXXC zinc finger mediates binding to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acetylated by CREBBP; leading to ubiquitination and subsequent proteasomal degradation. Deletion of the CXXC zinc finger domain of FBXL19 leads to mouse embryonic lethality. DNA binding protein binding zinc ion binding SCF ubiquitin ligase complex proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding uc291vxi.1 uc291vxi.2 
ENSMUST00000186212.2 Gm5891 ENSMUST00000186212.2 predicted gene 5891 (from RefSeq NM_001034904.2) ENSMUST00000186212.1 Gm10662 Gm5891 NM_001034904 Q3UT86 Q3UT86_MOUSE uc009fnx.1 uc009fnx.2 uc009fnx.3 uc009fnx.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. nucleotide binding microtubule cytoskeleton organization molecular_function protein kinase activity protein serine/threonine kinase activity ATP binding cellular_component cytoplasm protein phosphorylation biological_process intracellular signal transduction tau-protein kinase activity uc009fnx.1 uc009fnx.2 uc009fnx.3 uc009fnx.4 
ENSMUST00000186213.7 Tuba4a ENSMUST00000186213.7 tubulin, alpha 4A, transcript variant 1 (from RefSeq NM_009447.5) ENSMUST00000186213.1 ENSMUST00000186213.2 ENSMUST00000186213.3 ENSMUST00000186213.4 ENSMUST00000186213.5 ENSMUST00000186213.6 NM_009447 P05215 P68368 Q3TY31 TBA4A_MOUSE Tuba4 uc007bok.1 uc007bok.2 uc007bok.3 uc007bok.4 Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with CFAP157 (PubMed:27965440). Cytoplasm, cytoskeleton. The MREC motif may be critical for tubulin autoregulation. Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility (PubMed:33414192). Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:15890843). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (PubMed:23897886). Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly. Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability. Although this tubulin does not encode a C-terminal tyrosine, a C- terminal tyrosine can be added post-translationally by the tubulin tyrosine ligase (TTL). It can then undergo a detyrosination cycle by the tubulin tyrosine carboxypeptidase (KIAA0895L/MATCAP). This tubulin does not have a C-terminal tyrosine. Belongs to the tubulin family. Sequence=BAE34732.1; Type=Erroneous initiation; Evidence=; nucleotide binding microtubule cytoskeleton organization mitotic cell cycle GTPase activity structural constituent of cytoskeleton protein binding GTP binding cytoplasm cytoskeleton microtubule microtubule-based process microtubule cytoskeleton enzyme binding protein kinase binding uc007bok.1 uc007bok.2 uc007bok.3 uc007bok.4 
ENSMUST00000186216.2 Gm29237 ENSMUST00000186216.2 Gm29237 (from geneSymbol) ENSMUST00000186216.1 uc287xex.1 uc287xex.2 uc287xex.1 uc287xex.2 
ENSMUST00000186219.7 Zfp951 ENSMUST00000186219.7 zinc finger protein 951, transcript variant 1 (from RefSeq NM_001039231.3) A0A087WRH0 A0A087WRH0_MOUSE ENSMUST00000186219.1 ENSMUST00000186219.2 ENSMUST00000186219.3 ENSMUST00000186219.4 ENSMUST00000186219.5 ENSMUST00000186219.6 NM_001039231 Zfp951 uc012ead.1 uc012ead.2 uc012ead.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc012ead.1 uc012ead.2 uc012ead.3 
ENSMUST00000186223.2 Gm28595 ENSMUST00000186223.2 Gm28595 (from geneSymbol) ENSMUST00000186223.1 uc292tfk.1 uc292tfk.2 uc292tfk.1 uc292tfk.2 
ENSMUST00000186228.3 Ms4a12 ENSMUST00000186228.3 membrane-spanning 4-domains, subfamily A, member 12 (from RefSeq NM_001374133.1) A0A087WSB9 A0A087WSB9_MOUSE ENSMUST00000186228.1 ENSMUST00000186228.2 Ms4a12 NM_001374133 uc289qxy.1 uc289qxy.2 uc289qxy.3 Belongs to the MS4A family. molecular_function cellular_component biological_process membrane integral component of membrane uc289qxy.1 uc289qxy.2 uc289qxy.3 
ENSMUST00000186230.3 Gm28800 ENSMUST00000186230.3 Gm28800 (from geneSymbol) BC046462 ENSMUST00000186230.1 ENSMUST00000186230.2 uc287lkf.1 uc287lkf.2 uc287lkf.3 uc287lkf.1 uc287lkf.2 uc287lkf.3 
ENSMUST00000186234.3 Gm9885 ENSMUST00000186234.3 Gm9885 (from geneSymbol) AK077340 ENSMUST00000186234.1 ENSMUST00000186234.2 uc291rom.1 uc291rom.2 uc291rom.3 uc291rom.1 uc291rom.2 uc291rom.3 
ENSMUST00000186236.2 Gm28993 ENSMUST00000186236.2 Gm28993 (from geneSymbol) ENSMUST00000186236.1 uc292tgh.1 uc292tgh.2 uc292tgh.1 uc292tgh.2 
ENSMUST00000186238.2 Gm19325 ENSMUST00000186238.2 Gm19325 (from geneSymbol) AK135790 ENSMUST00000186238.1 uc292jvv.1 uc292jvv.2 uc292jvv.1 uc292jvv.2 
ENSMUST00000186239.7 Cep57l1 ENSMUST00000186239.7 centrosomal protein 57-like 1, transcript variant 1 (from RefSeq NM_029132.2) Cep57l1 ENSMUST00000186239.1 ENSMUST00000186239.2 ENSMUST00000186239.3 ENSMUST00000186239.4 ENSMUST00000186239.5 ENSMUST00000186239.6 G5E828 G5E828_MOUSE NM_029132 uc007exz.1 uc007exz.2 uc007exz.3 uc007exz.4 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Belongs to the translokin family. microtubule binding identical protein binding gamma-tubulin binding uc007exz.1 uc007exz.2 uc007exz.3 uc007exz.4 
ENSMUST00000186248.2 Gm28279 ENSMUST00000186248.2 Gm28279 (from geneSymbol) ENSMUST00000186248.1 uc292tig.1 uc292tig.2 uc292tig.1 uc292tig.2 
ENSMUST00000186250.2 Gm28138 ENSMUST00000186250.2 Gm28138 (from geneSymbol) ENSMUST00000186250.1 uc292ubh.1 uc292ubh.2 uc292ubh.1 uc292ubh.2 
ENSMUST00000186251.2 Gm29309 ENSMUST00000186251.2 Gm29309 (from geneSymbol) ENSMUST00000186251.1 uc292upl.1 uc292upl.2 uc292upl.1 uc292upl.2 
ENSMUST00000186258.3 C030007H22Rik ENSMUST00000186258.3 RIKEN cDNA C030007H22 gene (from RefSeq NR_040482.1) ENSMUST00000186258.1 ENSMUST00000186258.2 NR_040482 uc029qrn.1 uc029qrn.2 uc029qrn.3 uc029qrn.4 uc029qrn.1 uc029qrn.2 uc029qrn.3 uc029qrn.4 
ENSMUST00000186260.2 Gm29565 ENSMUST00000186260.2 Gm29565 (from geneSymbol) ENSMUST00000186260.1 uc292uqh.1 uc292uqh.2 uc292uqh.1 uc292uqh.2 
ENSMUST00000186264.2 Gm29106 ENSMUST00000186264.2 Nucleus (from UniProt A0A087WSP8) A0A087WSP8 A0A087WSP8_MOUSE ENSMUST00000186264.1 Gm29106 uc287lbi.1 uc287lbi.2 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc287lbi.1 uc287lbi.2 
ENSMUST00000186267.2 Gm28154 ENSMUST00000186267.2 Gm28154 (from geneSymbol) AK034407 ENSMUST00000186267.1 uc287gsd.1 uc287gsd.2 uc287gsd.1 uc287gsd.2 
ENSMUST00000186269.7 Gm28338 ENSMUST00000186269.7 Gm28338 (from geneSymbol) ENSMUST00000186269.1 ENSMUST00000186269.2 ENSMUST00000186269.3 ENSMUST00000186269.4 ENSMUST00000186269.5 ENSMUST00000186269.6 uc292tcs.1 uc292tcs.2 uc292tcs.1 uc292tcs.2 
ENSMUST00000186273.7 Gm28129 ENSMUST00000186273.7 Gm28129 (from geneSymbol) ENSMUST00000186273.1 ENSMUST00000186273.2 ENSMUST00000186273.3 ENSMUST00000186273.4 ENSMUST00000186273.5 ENSMUST00000186273.6 uc292svc.1 uc292svc.2 uc292svc.1 uc292svc.2 
ENSMUST00000186289.2 Gm29155 ENSMUST00000186289.2 Gm29155 (from geneSymbol) ENSMUST00000186289.1 uc287hsj.1 uc287hsj.2 uc287hsj.1 uc287hsj.2 
ENSMUST00000186291.2 Gm20324 ENSMUST00000186291.2 predicted gene, 20324 (from RefSeq NR_045068.1) ENSMUST00000186291.1 NR_045068 uc007wzq.1 uc007wzq.2 uc007wzq.3 uc007wzq.1 uc007wzq.2 uc007wzq.3 
ENSMUST00000186293.2 Gm28813 ENSMUST00000186293.2 Gm28813 (from geneSymbol) ENSMUST00000186293.1 uc292ura.1 uc292ura.2 uc292ura.1 uc292ura.2 
ENSMUST00000186297.2 Gm29028 ENSMUST00000186297.2 Gm29028 (from geneSymbol) ENSMUST00000186297.1 uc292tdc.1 uc292tdc.2 uc292tdc.1 uc292tdc.2 
ENSMUST00000186298.7 Gpr35 ENSMUST00000186298.7 G protein-coupled receptor 35, transcript variant 2 (from RefSeq NM_001104529.2) ENSMUST00000186298.1 ENSMUST00000186298.2 ENSMUST00000186298.3 ENSMUST00000186298.4 ENSMUST00000186298.5 ENSMUST00000186298.6 GPR35_MOUSE NM_001104529 Q9ES90 uc007cbz.1 uc007cbz.2 uc007cbz.3 uc007cbz.4 G-protein coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Plays a role in neutrophil recruitment to sites of inflammation and bacterial clearance through the major serotonin metabolite 5-HIAA that acts as a physiological ligand (By similarity). Stimulates lipid metabolism, thermogenic, and anti-inflammatory gene expression in adipose tissue once activated by kynurenic acid (PubMed:29414686). In macrophages, activation by lysophosphatidic acid promotes GPR35-induced signaling with a distinct transcriptional profile characterized by TNF production associated with ERK and NF-kappa-B activation. In turn, induces chemotaxis of macrophages (PubMed:32755573). Cell membrane ; Multi-pass membrane protein Predominantly expressed in immune and gastrointestinal tissues (PubMed:16754668). Strongly GPR35 expressed in colonic macrophages (PubMed:32755573). Expression is modulated by the microbiota and induced by inflammation. Multiply phosphorylated in clusters of serines and threonines in the C-terminal tail. Phosphorylation of Ser-298 and Ser-301 is mediated by GRK5 and/or GRK6. GPR35-deficient mice show compromised exercise- induced adipose tissue browning (PubMed:29414686). Conditional deletion in macrophages results in increased susceptibility to DSS-induced colitis, associated with reduced TNF production (PubMed:32755573). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity chemokine receptor activity plasma membrane integral component of plasma membrane cytoskeleton organization signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane C-X-C chemokine receptor activity positive regulation of Rho protein signal transduction signaling receptor activity macrophage chemotaxis positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway chemokine-mediated signaling pathway negative regulation of voltage-gated calcium channel activity negative regulation of neuronal action potential uc007cbz.1 uc007cbz.2 uc007cbz.3 uc007cbz.4 
ENSMUST00000186300.2 Gm28932 ENSMUST00000186300.2 Gm28932 (from geneSymbol) ENSMUST00000186300.1 uc288wrb.1 uc288wrb.2 uc288wrb.1 uc288wrb.2 
ENSMUST00000186303.7 Gm28557 ENSMUST00000186303.7 Belongs to the krueppel C2H2-type zinc-finger protein family. (from UniProt A0A087WQQ0) A0A087WQQ0 A0A087WQQ0_MOUSE BC076611 ENSMUST00000186303.1 ENSMUST00000186303.2 ENSMUST00000186303.3 ENSMUST00000186303.4 ENSMUST00000186303.5 ENSMUST00000186303.6 Gm28557 uc288odj.1 uc288odj.2 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc288odj.1 uc288odj.2 
ENSMUST00000186305.2 Gm29379 ENSMUST00000186305.2 Gm29379 (from geneSymbol) ENSMUST00000186305.1 uc292uce.1 uc292uce.2 uc292uce.1 uc292uce.2 
ENSMUST00000186312.7 ENSMUSG00000121290 ENSMUST00000186312.7 ENSMUSG00000121290 (from geneSymbol) ENSMUST00000186312.1 ENSMUST00000186312.2 ENSMUST00000186312.3 ENSMUST00000186312.4 ENSMUST00000186312.5 ENSMUST00000186312.6 uc292ukn.1 uc292ukn.2 uc292ukn.1 uc292ukn.2 
ENSMUST00000186321.7 Gm28130 ENSMUST00000186321.7 Gm28130 (from geneSymbol) ENSMUST00000186321.1 ENSMUST00000186321.2 ENSMUST00000186321.3 ENSMUST00000186321.4 ENSMUST00000186321.5 ENSMUST00000186321.6 uc292svj.1 uc292svj.2 uc292svj.1 uc292svj.2 
ENSMUST00000186327.2 Gm28750 ENSMUST00000186327.2 Gm28750 (from geneSymbol) ENSMUST00000186327.1 uc289ert.1 uc289ert.2 uc289ert.1 uc289ert.2 
ENSMUST00000186328.2 Gm28440 ENSMUST00000186328.2 Gm28440 (from geneSymbol) ENSMUST00000186328.1 uc292uxe.1 uc292uxe.2 uc292uxe.1 uc292uxe.2 
ENSMUST00000186329.2 Btbd35f15 ENSMUST00000186329.2 BTB domain containing 35, family member 15 (from RefSeq NM_001243015.1) A0A087WR44 A0A087WR44_MOUSE Btbd35f15 ENSMUST00000186329.1 Gm2913 NM_001243015 uc033jpc.1 uc033jpc.2 uc033jpc.3 molecular_function cellular_component biological_process uc033jpc.1 uc033jpc.2 uc033jpc.3 
ENSMUST00000186332.6 Gm29210 ENSMUST00000186332.6 Gm29210 (from geneSymbol) DQ874391 ENSMUST00000186332.1 ENSMUST00000186332.2 ENSMUST00000186332.3 ENSMUST00000186332.4 ENSMUST00000186332.5 uc029xzc.1 uc029xzc.2 uc029xzc.1 uc029xzc.2 
ENSMUST00000186334.3 Gm28942 ENSMUST00000186334.3 Gm28942 (from geneSymbol) ENSMUST00000186334.1 ENSMUST00000186334.2 uc287jst.1 uc287jst.2 uc287jst.3 uc287jst.1 uc287jst.2 uc287jst.3 
ENSMUST00000186337.2 Gm29055 ENSMUST00000186337.2 Gm29055 (from geneSymbol) ENSMUST00000186337.1 EU234054 uc287kbg.1 uc287kbg.2 uc287kbg.1 uc287kbg.2 
ENSMUST00000186340.2 Gm29009 ENSMUST00000186340.2 Gm29009 (from geneSymbol) ENSMUST00000186340.1 uc291jby.1 uc291jby.2 uc291jby.1 uc291jby.2 
ENSMUST00000186343.2 Gm28095 ENSMUST00000186343.2 Gm28095 (from geneSymbol) ENSMUST00000186343.1 uc287gqi.1 uc287gqi.2 uc287gqi.1 uc287gqi.2 
ENSMUST00000186357.2 Gm28547 ENSMUST00000186357.2 Gm28547 (from geneSymbol) ENSMUST00000186357.1 uc292tec.1 uc292tec.2 uc292tec.1 uc292tec.2 
ENSMUST00000186371.2 Gm29043 ENSMUST00000186371.2 Gm29043 (from geneSymbol) ENSMUST00000186371.1 uc292scs.1 uc292scs.2 uc292scs.1 uc292scs.2 
ENSMUST00000186372.2 Gm28798 ENSMUST00000186372.2 Gm28798 (from geneSymbol) ENSMUST00000186372.1 uc292suc.1 uc292suc.2 uc292suc.1 uc292suc.2 
ENSMUST00000186374.2 Gm28469 ENSMUST00000186374.2 Gm28469 (from geneSymbol) ENSMUST00000186374.1 uc292tcf.1 uc292tcf.2 uc292tcf.1 uc292tcf.2 
ENSMUST00000186375.8 Naa60 ENSMUST00000186375.8 N(alpha)-acetyltransferase 60, NatF catalytic subunit, transcript variant 1 (from RefSeq NM_029090.3) ENSMUST00000186375.1 ENSMUST00000186375.2 ENSMUST00000186375.3 ENSMUST00000186375.4 ENSMUST00000186375.5 ENSMUST00000186375.6 ENSMUST00000186375.7 NAA60_MOUSE NM_029090 Nat15 Q9DBU2 uc007xyw.1 uc007xyw.2 uc007xyw.3 uc007xyw.4 N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N- terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences. Reaction=acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]; Xref=Rhea:RHEA:50604, Rhea:RHEA-COMP:12745, Rhea:RHEA- COMP:12746, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64731, ChEBI:CHEBI:133414; EC=2.3.1.259; Evidence=; Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; Monomer and homodimer; monomer in presence of substrate and homodimer in its absence. Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Probably forms a intramembrane hairpin-like structure in the membrane. Acetylated: autoacetylation is required for optimal acetyltransferase activity. Belongs to the acetyltransferase family. NAA60 subfamily. Golgi membrane histone acetyltransferase activity peptide alpha-N-acetyltransferase activity Golgi apparatus chromatin organization nucleosome assembly N-terminal protein amino acid acetylation chromosome segregation N-acetyltransferase activity cell proliferation H4 histone acetyltransferase activity membrane transferase activity transferase activity, transferring acyl groups N-terminal peptidyl-methionine acetylation protein homodimerization activity histone H3 acetylation histone H4 acetylation uc007xyw.1 uc007xyw.2 uc007xyw.3 uc007xyw.4 
ENSMUST00000186378.2 Gm28421 ENSMUST00000186378.2 Gm28421 (from geneSymbol) ENSMUST00000186378.1 uc292ure.1 uc292ure.2 uc292ure.1 uc292ure.2 
ENSMUST00000186380.7 Dhx9 ENSMUST00000186380.7 DExH-box helicase 9, transcript variant 2 (from RefSeq NM_007842.3) A0A087WPL5 A0A087WPL5_MOUSE Dhx9 ENSMUST00000186380.1 ENSMUST00000186380.2 ENSMUST00000186380.3 ENSMUST00000186380.4 ENSMUST00000186380.5 ENSMUST00000186380.6 NM_007842 uc007czy.1 uc007czy.2 uc007czy.3 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Nucleus Belongs to the DEAD box helicase family. DEAH subfamily. nucleotide binding alternative mRNA splicing, via spliceosome RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core binding regulatory region RNA binding RNA polymerase II transcription factor binding nucleic acid binding DNA helicase activity DNA replication origin binding double-stranded DNA binding single-stranded DNA binding transcription cofactor activity transcription coactivator activity RNA binding RNA helicase activity double-stranded RNA binding single-stranded RNA binding mRNA binding helicase activity ATP binding nucleus nucleoplasm perichromatin fibrils cytoplasm centrosome polysome regulation of transcription from RNA polymerase II promoter RNA secondary structure unwinding actin cytoskeleton RISC complex nuclear body hydrolase activity ATPase activity targeting of mRNA for destruction involved in RNA interference chromatin DNA binding DNA duplex unwinding macromolecular complex 3'-5' DNA/RNA helicase activity 3'-5' RNA helicase activity cellular macromolecular complex assembly siRNA binding positive regulation of interferon-beta secretion RNA stem-loop binding cytoplasmic ribonucleoprotein granule DNA-templated viral transcription polysomal ribosome 3'-5' DNA helicase activity G-quadruplex DNA unwinding triplex DNA binding positive regulation of DNA repair positive regulation of DNA replication positive regulation of transcription from RNA polymerase II promoter positive regulation of RNA export from nucleus nucleoside-triphosphate diphosphatase activity positive regulation of fibroblast proliferation positive regulation of viral transcription regulation of mRNA processing positive regulation of NF-kappaB transcription factor activity positive regulation of response to cytokine stimulus importin-alpha family protein binding RNA polymerase binding RISC-loading complex small RNA loading onto RISC CRD-mediated mRNA stabilization CRD-mediated mRNA stability complex cellular response to tumor necrosis factor cellular response to exogenous dsRNA nuclear stress granule positive regulation of interferon-alpha secretion protein localization to cytoplasmic stress granule positive regulation of tumor necrosis factor secretion positive regulation of viral translation RISC complex binding polysome binding positive regulation of polysome binding single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity sequence-specific mRNA binding promoter-specific chromatin binding ribonucleoprotein complex positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity positive regulation of gene silencing by miRNA regulation of cytoplasmic translation positive regulation of cytoplasmic translation positive regulation of interleukin-6 secretion uc007czy.1 uc007czy.2 uc007czy.3 
ENSMUST00000186387.2 E330023G01Rik ENSMUST00000186387.2 RIKEN cDNA E330023G01 gene (from RefSeq NR_045332.1) ENSMUST00000186387.1 NR_045332 uc029xfq.1 uc029xfq.2 uc029xfq.1 uc029xfq.2 
ENSMUST00000186400.2 Gm29406 ENSMUST00000186400.2 Gm29406 (from geneSymbol) ENSMUST00000186400.1 uc292tth.1 uc292tth.2 uc292tth.1 uc292tth.2 
ENSMUST00000186407.2 Gm29447 ENSMUST00000186407.2 Gm29447 (from geneSymbol) ENSMUST00000186407.1 uc292ufe.1 uc292ufe.2 uc292ufe.1 uc292ufe.2 
ENSMUST00000186411.3 2600014E21Rik ENSMUST00000186411.3 2600014E21Rik (from geneSymbol) ENSMUST00000186411.1 ENSMUST00000186411.2 uc289xbp.1 uc289xbp.2 uc289xbp.1 uc289xbp.2 
ENSMUST00000186428.2 Gm29453 ENSMUST00000186428.2 Gm29453 (from geneSymbol) ENSMUST00000186428.1 uc287hzf.1 uc287hzf.2 uc287hzf.1 uc287hzf.2 
ENSMUST00000186443.2 Gm21294 ENSMUST00000186443.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WS79) A0A087WS79 A0A087WS79_MOUSE ENSMUST00000186443.1 Gm21294 uc292uzl.1 uc292uzl.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292uzl.1 uc292uzl.2 
ENSMUST00000186449.7 Gm29498 ENSMUST00000186449.7 Gm29498 (from geneSymbol) ENSMUST00000186449.1 ENSMUST00000186449.2 ENSMUST00000186449.3 ENSMUST00000186449.4 ENSMUST00000186449.5 ENSMUST00000186449.6 uc292tfe.1 uc292tfe.2 uc292tfe.1 uc292tfe.2 
ENSMUST00000186450.2 Gm28379 ENSMUST00000186450.2 Gm28379 (from geneSymbol) ENSMUST00000186450.1 uc292ihs.1 uc292ihs.2 uc292ihs.1 uc292ihs.2 
ENSMUST00000186453.2 C530043A13Rik ENSMUST00000186453.2 C530043A13Rik (from geneSymbol) ENSMUST00000186453.1 uc287jck.1 uc287jck.2 uc287jck.1 uc287jck.2 
ENSMUST00000186456.2 Mrgpra6 ENSMUST00000186456.2 Membrane ; Multi- pass membrane protein (from UniProt A0A087WQV0) A0A087WQV0 A0A087WQV0_MOUSE ENSMUST00000186456.1 Mrgpra6 NM_001308537 uc291qdx.1 uc291qdx.2 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc291qdx.1 uc291qdx.2 
ENSMUST00000186460.2 2310030A07Rik ENSMUST00000186460.2 RIKEN cDNA 2310030A07 gene (from RefSeq NR_040603.1) ENSMUST00000186460.1 NR_040603 uc029qty.1 uc029qty.2 uc029qty.1 uc029qty.2 
ENSMUST00000186465.7 Trip12 ENSMUST00000186465.7 E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Mediates ubiquitination of ASXL1: following binding to N(6)- methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex. (from UniProt G5E870) AK033327 ENSMUST00000186465.1 ENSMUST00000186465.2 ENSMUST00000186465.3 ENSMUST00000186465.4 ENSMUST00000186465.5 ENSMUST00000186465.6 G5E870 Q3TY88 Q3UYT5 Q8BM59 Q8K051 TRIPC_MOUSE uc007bsz.1 uc007bsz.2 uc007bsz.3 E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Mediates ubiquitination of ASXL1: following binding to N(6)- methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence=; Protein modification; protein ubiquitination. Interacts with MYC; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with TRADD; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with SMARCC1; leading to disrupt interaction with SMARCE1. Nucleus, nucleoplasm Embryonic lethality in the middle stage of development. Embryos exhibit growth arrest, while ES cells are viable. ES cells show decreased proliferation, but maintain both the undifferentiated state and the ability to differentiate. Belongs to the UPL family. K-HECT subfamily. ubiquitin-protein transferase activity nucleus nucleoplasm DNA repair ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus zinc ion binding protein ubiquitination nuclear speck transferase activity regulation of embryonic development thyroid hormone receptor binding negative regulation of histone H2A K63-linked ubiquitination negative regulation of double-strand break repair uc007bsz.1 uc007bsz.2 uc007bsz.3 
ENSMUST00000186469.7 Rhof ENSMUST00000186469.7 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology (By similarity). (from UniProt Q8BYP3) AK038837 Arhf ENSMUST00000186469.1 ENSMUST00000186469.2 ENSMUST00000186469.3 ENSMUST00000186469.4 ENSMUST00000186469.5 ENSMUST00000186469.6 Q8BYP3 RHOF_MOUSE uc290znr.1 uc290znr.2 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Cytoplasm, cytoskeleton. Belongs to the small GTPase superfamily. Rho family. nucleotide binding GTPase activity GTP binding cytoplasm cytoskeleton plasma membrane cell cortex actin filament organization small GTPase mediated signal transduction Rho protein signal transduction regulation of cell shape membrane cell migration protein kinase binding regulation of cell migration establishment or maintenance of actin cytoskeleton polarity cell division site regulation of actin cytoskeleton organization intracellular membrane-bounded organelle actin filament bundle assembly uc290znr.1 uc290znr.2 
ENSMUST00000186470.2 Kansl3 ENSMUST00000186470.2 KAT8 regulatory NSL complex subunit 3, transcript variant 1 (from RefSeq NM_001310513.1) A2RSY1 ENSMUST00000186470.1 KANL3_MOUSE Kiaa1310 NM_001310513 Nsl3 Q6ZPU0 Q8C0P9 uc287hgy.1 uc287hgy.2 As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2RSY1-1; Sequence=Displayed; Name=2; IsoId=A2RSY1-2; Sequence=VSP_025335; Name=3; IsoId=A2RSY1-3; Sequence=VSP_025334, VSP_025335; Sequence=BAC98139.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; histone acetyltransferase complex nucleus nucleoplasm nucleolus chromatin organization intracellular membrane-bounded organelle histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) NSL complex histone acetyltransferase activity (H4-K16 specific) uc287hgy.1 uc287hgy.2 
ENSMUST00000186471.2 Gm12500 ENSMUST00000186471.2 Gm12500 (from geneSymbol) AK083112 ENSMUST00000186471.1 uc290irg.1 uc290irg.2 uc290irg.1 uc290irg.2 
ENSMUST00000186474.4 2410022M11Rik ENSMUST00000186474.4 RIKEN cDNA 2410022M11 gene (from RefSeq NR_152252.1) ENSMUST00000186474.1 ENSMUST00000186474.2 ENSMUST00000186474.3 NR_152252 uc007ucq.1 uc007ucq.2 uc007ucq.3 uc007ucq.4 uc007ucq.1 uc007ucq.2 uc007ucq.3 uc007ucq.4 
ENSMUST00000186475.2 Zfp383 ENSMUST00000186475.2 zinc finger protein 383 (from RefSeq NM_001243908.1) A0A087WRR7 A0A087WRR7_MOUSE ENSMUST00000186475.1 NM_001243908 Zfp383 uc009gcn.1 uc009gcn.2 uc009gcn.3 uc009gcn.4 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated nuclear membrane sequence-specific DNA binding metal ion binding uc009gcn.1 uc009gcn.2 uc009gcn.3 uc009gcn.4 
ENSMUST00000186478.7 ENSMUSG00000121327 ENSMUST00000186478.7 ENSMUSG00000121327 (from geneSymbol) ENSMUST00000186478.1 ENSMUST00000186478.2 ENSMUST00000186478.3 ENSMUST00000186478.4 ENSMUST00000186478.5 ENSMUST00000186478.6 uc292uar.1 uc292uar.2 uc292uar.1 uc292uar.2 
ENSMUST00000186480.3 Zbtb11os1 ENSMUST00000186480.3 Zbtb11os1 (from geneSymbol) ENSMUST00000186480.1 ENSMUST00000186480.2 uc007zlw.1 uc007zlw.2 uc007zlw.3 uc007zlw.4 uc007zlw.5 uc007zlw.1 uc007zlw.2 uc007zlw.3 uc007zlw.4 uc007zlw.5 
ENSMUST00000186485.7 Pign ENSMUST00000186485.7 phosphatidylinositol glycan anchor biosynthesis, class N (from RefSeq NM_013784.3) ENSMUST00000186485.1 ENSMUST00000186485.2 ENSMUST00000186485.3 ENSMUST00000186485.4 ENSMUST00000186485.5 ENSMUST00000186485.6 G3X9F1 G3X9F1_MOUSE NM_013784 Pign uc007cgf.1 uc007cgf.2 uc007cgf.3 uc007cgf.4 uc007cgf.5 Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Endoplasmic reticulum membrane ; Multi- pass membrane protein mbrane ; Multi-pass membrane protein Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily. catalytic activity endoplasmic reticulum membrane cytosol plasma membrane GPI anchor biosynthetic process membrane integral component of membrane transferase activity mannose-ethanolamine phosphotransferase activity uc007cgf.1 uc007cgf.2 uc007cgf.3 uc007cgf.4 uc007cgf.5 
ENSMUST00000186493.2 Gm20906 ENSMUST00000186493.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE ENSMUST00000186493.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292uxz.1 uc292uxz.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292uxz.1 uc292uxz.2 
ENSMUST00000186504.2 Gm29455 ENSMUST00000186504.2 Gm29455 (from geneSymbol) AK039419 ENSMUST00000186504.1 uc007ciq.1 uc007ciq.2 uc007ciq.3 uc007ciq.1 uc007ciq.2 uc007ciq.3 
ENSMUST00000186506.2 Gm28799 ENSMUST00000186506.2 Gm28799 (from geneSymbol) ENSMUST00000186506.1 uc292sub.1 uc292sub.2 uc292sub.1 uc292sub.2 
ENSMUST00000186516.2 Gm28406 ENSMUST00000186516.2 Gm28406 (from geneSymbol) ENSMUST00000186516.1 uc292uyv.1 uc292uyv.2 uc292uyv.1 uc292uyv.2 
ENSMUST00000186521.2 Gm28072 ENSMUST00000186521.2 Gm28072 (from geneSymbol) ENSMUST00000186521.1 uc292tve.1 uc292tve.2 uc292tve.1 uc292tve.2 
ENSMUST00000186525.2 Lce1j ENSMUST00000186525.2 late cornified envelope 1J (from RefSeq NM_001281499.1) D3YUU5 D3YUU5_MOUSE ENSMUST00000186525.1 Lce1j NM_001281499 uc033hwd.1 uc033hwd.2 uc033hwd.3 uc033hwd.4 Belongs to the LCE family. uc033hwd.1 uc033hwd.2 uc033hwd.3 uc033hwd.4 
ENSMUST00000186529.2 Scgb2b18 ENSMUST00000186529.2 secretoglobin, family 2B, member 18 (from RefSeq NM_001310621.1) A0A087WPA9 A0A087WPA9_MOUSE Abpbg18 ENSMUST00000186529.1 NM_001310621 Scgb2b18 uc057bzp.1 uc057bzp.2 uc057bzp.3 Secreted Belongs to the secretoglobin family. molecular_function cellular_component extracellular space biological_process uc057bzp.1 uc057bzp.2 uc057bzp.3 
ENSMUST00000186531.4 2810013P06Rik ENSMUST00000186531.4 RIKEN cDNA 2810013P06 gene (from RefSeq NR_045268.1) ENSMUST00000186531.1 ENSMUST00000186531.2 ENSMUST00000186531.3 NR_045268 uc029wwr.1 uc029wwr.2 uc029wwr.3 uc029wwr.4 uc029wwr.5 uc029wwr.1 uc029wwr.2 uc029wwr.3 uc029wwr.4 uc029wwr.5 
ENSMUST00000186532.8 1700029B22Rik ENSMUST00000186532.8 RIKEN cDNA 1700029B22 gene (from RefSeq NR_040531.1) ENSMUST00000186532.1 ENSMUST00000186532.2 ENSMUST00000186532.3 ENSMUST00000186532.4 ENSMUST00000186532.5 ENSMUST00000186532.6 ENSMUST00000186532.7 NR_040531 uc029woz.1 uc029woz.2 uc029woz.3 uc029woz.4 uc029woz.1 uc029woz.2 uc029woz.3 uc029woz.4 
ENSMUST00000186533.2 Gm28083 ENSMUST00000186533.2 Gm28083 (from geneSymbol) ENSMUST00000186533.1 uc287ipt.1 uc287ipt.2 uc287ipt.1 uc287ipt.2 
ENSMUST00000186540.7 Gm28761 ENSMUST00000186540.7 Gm28761 (from geneSymbol) ENSMUST00000186540.1 ENSMUST00000186540.2 ENSMUST00000186540.3 ENSMUST00000186540.4 ENSMUST00000186540.5 ENSMUST00000186540.6 uc292syo.1 uc292syo.2 uc292syo.1 uc292syo.2 
ENSMUST00000186548.7 Tet3 ENSMUST00000186548.7 tet methylcytosine dioxygenase 3, transcript variant 1 (from RefSeq NM_001347313.1) ENSMUST00000186548.1 ENSMUST00000186548.2 ENSMUST00000186548.3 ENSMUST00000186548.4 ENSMUST00000186548.5 ENSMUST00000186548.6 K9JH93 L0HN04 NM_001347313 Q4VAD3 Q8BG87 Q8C8N8 Q8CI60 TET3_MOUSE uc033isr.1 uc033isr.2 uc033isr.3 uc033isr.4 Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5- carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity). Reaction=2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate; Xref=Rhea:RHEA:52636, Rhea:RHEA-COMP:11370, Rhea:RHEA-COMP:13315, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:85454, ChEBI:CHEBI:136731; EC=1.14.11.80; Evidence= Reaction=2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 = a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate; Xref=Rhea:RHEA:53828, Rhea:RHEA-COMP:13315, Rhea:RHEA-COMP:13656, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:136731, ChEBI:CHEBI:137731; EC=1.14.11.80; Evidence=; Reaction=2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate; Xref=Rhea:RHEA:53832, Rhea:RHEA-COMP:13656, Rhea:RHEA-COMP:13657, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:137731, ChEBI:CHEBI:137732; EC=1.14.11.80; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=The zinc ions have a structural role. ; Interacts with HCFC1 (By similarity). Interacts with OGT (By similarity). Directly interacts (via C-terminus) with the DCAF1 component of the CRL4(VprBP) E3 ubiquitin-protein ligase complex (By similarity). Q8BG87; O15294: OGT; Xeno; NbExp=2; IntAct=EBI-9031997, EBI-539828; Nucleus romosome Cytoplasm Note=At the zygotic stage, localizes in the male and female pronucleus, while it localizes to the cytoplasm at other preimplantation stages (PubMed:21892189, PubMed:28930672). Binds to the promoter of target genes, close to the transcription start site (PubMed:26774490). Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q8BG87-1; Sequence=Displayed; Name=2; IsoId=Q8BG87-2; Sequence=VSP_060404, VSP_060406, VSP_060407; Name=1; IsoId=Q8BG87-4; Sequence=VSP_060405; Highly expressed in germinal vesicle (GV) stage and MII-stage oocytes and in early embryos. Expressed maternally. Expressed at high levels in germinal vesicle (GV) stage and MII-stage oocytes. Expressed at lower levels in one-cell embryos until 4-cell stage. Hardly detectable in morula. Expressed mainly in somatic cells from 9.5 dpc until at least 16.5 dpc. Expression in primordial germ cells is undetectable until 13.5 dpc and peaks at 16.5 dpc (PubMed:23151479). The CXXC-type zinc-finger domain mediates binding to DNA sequences containing unmethylated cytosine or 5-carboxylcytosine in 5'- CCG-3' DNA sequence motifs (PubMed:26774490). It mediates binding to CpG-DNA (By similarity). Monoubiquitinated at Lys-1002 by the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex called CRL4(VprBP) or CUL4A-RBX1-DDB1- DCAF1/VPRBP complex; this modification promotes binding to DNA. Neonatal lethality. A germline-specific conditional knockout produces females that are normal in growth and morphology but display much reduced fecundity in terms of the frequency of successful pregnancy per mating and the litter size. No 5hmC signal is detected in the late male pronuclei of zygotes collected from the conditional knockout females mated with wild-type males. In contrast, deletion of Tet3 from the male germ cells does not seem to affect the change in 5hmC and 5mC. Belongs to the TET family. Subsequent steps in cytosine demethylation are subject to discussion. According to a first model cytosine demethylation occurs through deamination of 5hmC into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. According to another model, cytosine demethylation is rather mediated via conversion of 5hmC into 5fC and 5caC, followed by excision by TDG. Sequence=AAH96437.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH96437.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; female pronucleus male pronucleus DNA binding iron ion binding protein binding nucleus nucleoplasm chromosome cytoplasm 5-methylcytosine catabolic process chromatin organization protein O-linked glycosylation multicellular organism development oxidoreductase activity oxidative DNA demethylation DNA demethylation of male pronucleus positive regulation of transcription from RNA polymerase II promoter metal ion binding dioxygenase activity oxidation-reduction process methylcytosine dioxygenase activity oxidative demethylation DNA demethylation histone H3-K4 trimethylation uc033isr.1 uc033isr.2 uc033isr.3 uc033isr.4 
ENSMUST00000186549.2 Gm28668 ENSMUST00000186549.2 Gm28668 (from geneSymbol) ENSMUST00000186549.1 uc292uji.1 uc292uji.2 uc292uji.1 uc292uji.2 
ENSMUST00000186550.2 Gm21428 ENSMUST00000186550.2 Gm21428 (from geneSymbol) ENSMUST00000186550.1 uc292tvd.1 uc292tvd.2 uc292tvd.1 uc292tvd.2 
ENSMUST00000186560.2 Gm28100 ENSMUST00000186560.2 Gm28100 (from geneSymbol) AK131861 ENSMUST00000186560.1 uc287jyq.1 uc287jyq.2 uc287jyq.1 uc287jyq.2 
ENSMUST00000186562.2 Gm28673 ENSMUST00000186562.2 Gm28673 (from geneSymbol) ENSMUST00000186562.1 uc292uzs.1 uc292uzs.2 uc292uzs.1 uc292uzs.2 
ENSMUST00000186563.2 Gm28237 ENSMUST00000186563.2 Gm28237 (from geneSymbol) ENSMUST00000186563.1 EU234013 uc287gxe.1 uc287gxe.2 uc287gxe.1 uc287gxe.2 
ENSMUST00000186564.7 Gm29426 ENSMUST00000186564.7 Gm29426 (from geneSymbol) ENSMUST00000186564.1 ENSMUST00000186564.2 ENSMUST00000186564.3 ENSMUST00000186564.4 ENSMUST00000186564.5 ENSMUST00000186564.6 uc292tin.1 uc292tin.2 uc292tin.1 uc292tin.2 
ENSMUST00000186567.2 Gm28663 ENSMUST00000186567.2 Gm28663 (from geneSymbol) ENSMUST00000186567.1 uc292uqn.1 uc292uqn.2 uc292uqn.1 uc292uqn.2 
ENSMUST00000186568.7 Ncf2 ENSMUST00000186568.7 neutrophil cytosolic factor 2, transcript variant 1 (from RefSeq NM_010877.6) ENSMUST00000186568.1 ENSMUST00000186568.2 ENSMUST00000186568.3 ENSMUST00000186568.4 ENSMUST00000186568.5 ENSMUST00000186568.6 NCF2_MOUSE NM_010877 Ncf2 Noxa2 O70145 P67phox Q3TC92 Q3U5S4 uc007czm.1 uc007czm.2 uc007czm.3 uc007czm.4 NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4 (By similarity). Interacts with NCF4 (PubMed:21551061). Interacts (via the C-terminal SH3 domain) with NCF1 (via C-terminus). Interacts with SYTL1 and RAC1. May interact with NOXO1. Interacts with S100A8 and calprotectin (S100A8/9) (By similarity). Interacts with GBP7 (via GB1/RHD3-type G domain) (PubMed:21551061). Interacts with CYBB; the interaction is enhanced in the presence of GBP7 (PubMed:21551061). O70145; O08709: Prdx6; NbExp=3; IntAct=EBI-9550667, EBI-444895; Cytoplasm The OPR/PB1 domain mediates the association with NCF4/p40-PHOX. Belongs to the NCF2/NOXA1 family. acrosomal vesicle protein binding nucleolus cytoplasm cytosol NADP catabolic process superoxide metabolic process phagocytosis protein C-terminus binding response to glucose response to organic cyclic compound membrane superoxide-generating NADPH oxidase activator activity response to lipopolysaccharide cellular response to hormone stimulus superoxide anion generation NADPH oxidase complex positive regulation of catalytic activity positive regulation of neuron apoptotic process respiratory burst positive regulation of blood pressure Rac GTPase binding oxidation-reduction process superoxide-generating NADPH oxidase activity uc007czm.1 uc007czm.2 uc007czm.3 uc007czm.4 
ENSMUST00000186570.2 Gm29242 ENSMUST00000186570.2 Gm29242 (from geneSymbol) ENSMUST00000186570.1 uc292nzj.1 uc292nzj.2 uc292nzj.1 uc292nzj.2 
ENSMUST00000186578.2 Gm20929 ENSMUST00000186578.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE BC049626 ENSMUST00000186578.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292tqi.1 uc292tqi.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292tqi.1 uc292tqi.2 
ENSMUST00000186581.2 Gm29370 ENSMUST00000186581.2 Gm29370 (from geneSymbol) ENSMUST00000186581.1 uc292tks.1 uc292tks.2 uc292tks.1 uc292tks.2 
ENSMUST00000186582.2 D530049I02Rik ENSMUST00000186582.2 RIKEN cDNA D530049I02 gene (from RefSeq NR_040605.1) ENSMUST00000186582.1 NR_040605 uc029qpc.1 uc029qpc.2 uc029qpc.3 uc029qpc.1 uc029qpc.2 uc029qpc.3 
ENSMUST00000186583.7 Ash1l ENSMUST00000186583.7 Histone methyltransferase specifically trimethylating 'Lys- 36' of histone H3 forming H3K36me3 (By similarity). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (PubMed:22939622). The physiological significance of the H3K9me1 activity is unclear (Probable) (PubMed:22939622). (from UniProt Q99MY8) AF247132 ASH1L_MOUSE E9QNM2 ENSMUST00000186583.1 ENSMUST00000186583.2 ENSMUST00000186583.3 ENSMUST00000186583.4 ENSMUST00000186583.5 ENSMUST00000186583.6 Q3U598 Q80VY5 Q8BM69 Q8BTX0 Q8BZY6 Q99MY8 uc008pxj.1 uc008pxj.2 uc008pxj.3 Histone methyltransferase specifically trimethylating 'Lys- 36' of histone H3 forming H3K36me3 (By similarity). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (PubMed:22939622). The physiological significance of the H3K9me1 activity is unclear (Probable) (PubMed:22939622). Reaction=L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60324, Rhea:RHEA-COMP:9785, Rhea:RHEA- COMP:15536, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.359; Evidence=; Reaction=L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60280, Rhea:RHEA-COMP:15542, Rhea:RHEA-COMP:15546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.367; Evidence=; Nucleus Cell junction, tight junction Chromosome Note=The relevance of tight junction localization is however unclear. Methylated at Gln-1218 by N6AMT1. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. Sequence=AAK26242.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE32182.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; skeletal system development negative regulation of acute inflammatory response DNA binding chromatin binding nucleus nucleoplasm chromosome Golgi apparatus bicellular tight junction chromatin organization single fertilization methyltransferase activity post-embryonic development regulation of gene expression transferase activity histone-lysine N-methyltransferase activity cell junction flagellated sperm motility methylation interleukin-6 production histone methyltransferase activity (H3-K4 specific) negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAPK cascade positive regulation of transcription from RNA polymerase II promoter decidualization metal ion binding histone methyltransferase activity (H3-K9 specific) histone methyltransferase activity (H3-K36 specific) sebaceous gland development negative regulation of inflammatory response histone H3-K9 methylation histone H3-K4 methylation uterus morphogenesis histone H3-K36 dimethylation tarsal gland development uterine gland development uc008pxj.1 uc008pxj.2 uc008pxj.3 
ENSMUST00000186584.2 Gm28991 ENSMUST00000186584.2 Gm28991 (from geneSymbol) ENSMUST00000186584.1 uc289rwg.1 uc289rwg.2 uc289rwg.1 uc289rwg.2 
ENSMUST00000186587.2 Gm28398 ENSMUST00000186587.2 Gm28398 (from geneSymbol) ENSMUST00000186587.1 uc292sbs.1 uc292sbs.2 uc292sbs.1 uc292sbs.2 
ENSMUST00000186589.2 Gm28704 ENSMUST00000186589.2 Gm28704 (from geneSymbol) ENSMUST00000186589.1 uc292upr.1 uc292upr.2 uc292upr.1 uc292upr.2 
ENSMUST00000186604.2 Gm28376 ENSMUST00000186604.2 Gm28376 (from geneSymbol) ENSMUST00000186604.1 uc287grr.1 uc287grr.2 uc287grr.1 uc287grr.2 
ENSMUST00000186612.2 Gm28287 ENSMUST00000186612.2 Gm28287 (from geneSymbol) ENSMUST00000186612.1 uc287gud.1 uc287gud.2 uc287gud.1 uc287gud.2 
ENSMUST00000186615.7 Gm28565 ENSMUST00000186615.7 Gm28565 (from geneSymbol) ENSMUST00000186615.1 ENSMUST00000186615.2 ENSMUST00000186615.3 ENSMUST00000186615.4 ENSMUST00000186615.5 ENSMUST00000186615.6 uc292tkc.1 uc292tkc.2 uc292tkc.1 uc292tkc.2 
ENSMUST00000186619.7 Zfp1006 ENSMUST00000186619.7 Zfp1006 (from geneSymbol) 2610044O15Rik8 A0A087WRJ1 A0A087WRJ1_MOUSE AK011776 ENSMUST00000186619.1 ENSMUST00000186619.2 ENSMUST00000186619.3 ENSMUST00000186619.4 ENSMUST00000186619.5 ENSMUST00000186619.6 Zfp1006 uc292eey.1 uc292eey.2 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc292eey.1 uc292eey.2 
ENSMUST00000186630.2 Gm21633 ENSMUST00000186630.2 Gm21633 (from geneSymbol) ENSMUST00000186630.1 FJ386436 uc292szt.1 uc292szt.2 uc292szt.1 uc292szt.2 
ENSMUST00000186631.2 Gm17522 ENSMUST00000186631.2 Gm17522 (from geneSymbol) ENSMUST00000186631.1 FJ386434 uc292qjs.1 uc292qjs.2 uc292qjs.1 uc292qjs.2 
ENSMUST00000186632.2 C78334 ENSMUST00000186632.2 C78334 (from geneSymbol) ENSMUST00000186632.1 uc292jto.1 uc292jto.2 uc292jto.1 uc292jto.2 
ENSMUST00000186636.3 Gm7358 ENSMUST00000186636.3 May play a role in sperm motility, especially in the regulation of flagellar function. (from UniProt A0A087WSA6) A0A087WSA6 A0A087WSA6_MOUSE ENSMUST00000186636.1 ENSMUST00000186636.2 Gm7358 uc289heb.1 uc289heb.2 May play a role in sperm motility, especially in the regulation of flagellar function. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily. protein kinase activity ATP binding protein phosphorylation uc289heb.1 uc289heb.2 
ENSMUST00000186654.2 Gm28352 ENSMUST00000186654.2 Gm28352 (from geneSymbol) ENSMUST00000186654.1 uc292tsd.1 uc292tsd.2 uc292tsd.1 uc292tsd.2 
ENSMUST00000186665.7 Gm29514 ENSMUST00000186665.7 Gm29514 (from geneSymbol) AK158929 ENSMUST00000186665.1 ENSMUST00000186665.2 ENSMUST00000186665.3 ENSMUST00000186665.4 ENSMUST00000186665.5 ENSMUST00000186665.6 uc007cxm.1 uc007cxm.2 uc007cxm.3 uc007cxm.1 uc007cxm.2 uc007cxm.3 
ENSMUST00000186666.2 Gm28852 ENSMUST00000186666.2 Gm28852 (from geneSymbol) ENSMUST00000186666.1 uc292ssm.1 uc292ssm.2 uc292ssm.1 uc292ssm.2 
ENSMUST00000186677.2 Gm28447 ENSMUST00000186677.2 predicted gene 28447 (from RefSeq NR_188940.1) ENSMUST00000186677.1 NR_188940 uc287rnk.1 uc287rnk.2 uc287rnk.1 uc287rnk.2 
ENSMUST00000186679.2 Gm28297 ENSMUST00000186679.2 Gm28297 (from geneSymbol) ENSMUST00000186679.1 uc292sxo.1 uc292sxo.2 uc292sxo.1 uc292sxo.2 
ENSMUST00000186681.2 Gm29187 ENSMUST00000186681.2 Gm29187 (from geneSymbol) ENSMUST00000186681.1 uc287jpb.1 uc287jpb.2 uc287jpb.1 uc287jpb.2 
ENSMUST00000186686.2 Gm28890 ENSMUST00000186686.2 Gm28890 (from geneSymbol) ENSMUST00000186686.1 uc292tvv.1 uc292tvv.2 uc292tvv.1 uc292tvv.2 
ENSMUST00000186695.2 Gm29347 ENSMUST00000186695.2 Gm29347 (from geneSymbol) ENSMUST00000186695.1 uc287lfq.1 uc287lfq.2 uc287lfq.1 uc287lfq.2 
ENSMUST00000186709.2 Gm28092 ENSMUST00000186709.2 Gm28092 (from geneSymbol) ENSMUST00000186709.1 FJ386436 uc292svx.1 uc292svx.2 uc292svx.1 uc292svx.2 
ENSMUST00000186712.2 1700101I19Rik ENSMUST00000186712.2 1700101I19Rik (from geneSymbol) AK007108 ENSMUST00000186712.1 uc287hep.1 uc287hep.2 uc287hep.1 uc287hep.2 
ENSMUST00000186727.7 Gm29321 ENSMUST00000186727.7 Gm29321 (from geneSymbol) ENSMUST00000186727.1 ENSMUST00000186727.2 ENSMUST00000186727.3 ENSMUST00000186727.4 ENSMUST00000186727.5 ENSMUST00000186727.6 uc292tng.1 uc292tng.2 uc292tng.1 uc292tng.2 
ENSMUST00000186732.2 4930521E06Rik ENSMUST00000186732.2 RIKEN cDNA 4930521E06 gene (from RefSeq NR_040602.1) ENSMUST00000186732.1 NR_040602 uc029qoa.1 uc029qoa.2 uc029qoa.3 uc029qoa.1 uc029qoa.2 uc029qoa.3 
ENSMUST00000186733.7 Phf3 ENSMUST00000186733.7 PHD finger protein 3, transcript variant 3 (from RefSeq NM_001403130.1) B2RQG2 B2RQG2_MOUSE ENSMUST00000186733.1 ENSMUST00000186733.2 ENSMUST00000186733.3 ENSMUST00000186733.4 ENSMUST00000186733.5 ENSMUST00000186733.6 NM_001403130 Phf3 uc287gzk.1 uc287gzk.2 molecular_function cellular_component transcription, DNA-templated biological_process metal ion binding uc287gzk.1 uc287gzk.2 
ENSMUST00000186739.2 Gm20824 ENSMUST00000186739.2 predicted gene, 20824 (from RefSeq NM_001378622.1) A0A087WS97 A0A087WS97_MOUSE ENSMUST00000186739.1 Gm20824 NM_001378622 uc292scw.1 uc292scw.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292scw.1 uc292scw.2 
ENSMUST00000186747.2 Gm28108 ENSMUST00000186747.2 Gm28108 (from geneSymbol) ENSMUST00000186747.1 uc292uyd.1 uc292uyd.2 uc292uyd.1 uc292uyd.2 
ENSMUST00000186756.2 Gm29025 ENSMUST00000186756.2 Gm29025 (from geneSymbol) ENSMUST00000186756.1 uc292tdh.1 uc292tdh.2 uc292tdh.1 uc292tdh.2 
ENSMUST00000186757.7 ENSMUSG00000121291 ENSMUST00000186757.7 ENSMUSG00000121291 (from geneSymbol) ENSMUST00000186757.1 ENSMUST00000186757.2 ENSMUST00000186757.3 ENSMUST00000186757.4 ENSMUST00000186757.5 ENSMUST00000186757.6 uc292uld.1 uc292uld.2 uc292uld.1 uc292uld.2 
ENSMUST00000186771.2 Gm28964 ENSMUST00000186771.2 Gm28964 (from geneSymbol) ENSMUST00000186771.1 uc292ttm.1 uc292ttm.2 uc292ttm.1 uc292ttm.2 
ENSMUST00000186773.2 Gm29005 ENSMUST00000186773.2 Gm29005 (from geneSymbol) ENSMUST00000186773.1 uc291fyu.1 uc291fyu.2 uc291fyu.1 uc291fyu.2 
ENSMUST00000186782.2 Gm28218 ENSMUST00000186782.2 Gm28218 (from geneSymbol) ENSMUST00000186782.1 uc292uww.1 uc292uww.2 uc292uww.1 uc292uww.2 
ENSMUST00000186801.2 Gm29497 ENSMUST00000186801.2 Gm29497 (from geneSymbol) ENSMUST00000186801.1 uc292tfb.1 uc292tfb.2 uc292tfb.1 uc292tfb.2 
ENSMUST00000186805.2 Gm28394 ENSMUST00000186805.2 Gm28394 (from geneSymbol) ENSMUST00000186805.1 uc292sby.1 uc292sby.2 uc292sby.1 uc292sby.2 
ENSMUST00000186817.2 Gm28323 ENSMUST00000186817.2 Gm28323 (from geneSymbol) AK086109 ENSMUST00000186817.1 uc287hzh.1 uc287hzh.2 uc287hzh.1 uc287hzh.2 
ENSMUST00000186821.2 A930006L05Rik ENSMUST00000186821.2 A930006L05Rik (from geneSymbol) AK044309 ENSMUST00000186821.1 uc292juw.1 uc292juw.2 uc292juw.1 uc292juw.2 
ENSMUST00000186838.2 D730045B01Rik ENSMUST00000186838.2 D730045B01Rik (from geneSymbol) AK080901 ENSMUST00000186838.1 uc009aup.1 uc009aup.2 uc009aup.3 uc009aup.1 uc009aup.2 uc009aup.3 
ENSMUST00000186844.2 Gm28592 ENSMUST00000186844.2 Gm28592 (from geneSymbol) ENSMUST00000186844.1 uc287uvl.1 uc287uvl.2 uc287uvl.1 uc287uvl.2 
ENSMUST00000186847.2 Gm28135 ENSMUST00000186847.2 Gm28135 (from geneSymbol) ENSMUST00000186847.1 uc292ubb.1 uc292ubb.2 uc292ubb.1 uc292ubb.2 
ENSMUST00000186850.2 Gm21572 ENSMUST00000186850.2 Gm21572 (from geneSymbol) ENSMUST00000186850.1 FJ386436 uc292sxm.1 uc292sxm.2 uc292sxm.1 uc292sxm.2 
ENSMUST00000186866.2 Cdhr17 ENSMUST00000186866.2 Cdhr17 (from geneSymbol) ENSMUST00000186866.1 uc290thq.1 uc290thq.2 uc290thq.1 uc290thq.2 
ENSMUST00000186871.2 Gm29226 ENSMUST00000186871.2 Gm29226 (from geneSymbol) ENSMUST00000186871.1 uc292tba.1 uc292tba.2 uc292tba.1 uc292tba.2 
ENSMUST00000186874.3 Krtap10-31 ENSMUST00000186874.3 predicted gene 10318 (from RefSeq NM_001162944.1) A0A1W2P728 A0A1W2P728_MOUSE ENSMUST00000186874.1 ENSMUST00000186874.2 Gm10318 NM_001162944 uc011xhm.1 uc011xhm.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc011xhm.1 uc011xhm.2 
ENSMUST00000186876.2 Gm29542 ENSMUST00000186876.2 Gm29542 (from geneSymbol) ENSMUST00000186876.1 uc288ftr.1 uc288ftr.2 uc288ftr.1 uc288ftr.2 
ENSMUST00000186880.2 Gm28228 ENSMUST00000186880.2 Gm28228 (from geneSymbol) ENSMUST00000186880.1 uc289roc.1 uc289roc.2 uc289roc.1 uc289roc.2 
ENSMUST00000186883.2 Gm29158 ENSMUST00000186883.2 Gm29158 (from geneSymbol) ENSMUST00000186883.1 uc292rzy.1 uc292rzy.2 uc292rzy.1 uc292rzy.2 
ENSMUST00000186885.2 Gm28187 ENSMUST00000186885.2 Gm28187 (from geneSymbol) BC026787 ENSMUST00000186885.1 uc287kuq.1 uc287kuq.2 uc287kuq.1 uc287kuq.2 
ENSMUST00000186886.2 Gm29654 ENSMUST00000186886.2 Gm29654 (from geneSymbol) ENSMUST00000186886.1 uc292tai.1 uc292tai.2 uc292tai.1 uc292tai.2 
ENSMUST00000186890.7 Gm20888 ENSMUST00000186890.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WQA3) A0A087WQA3 A0A087WQA3_MOUSE ENSMUST00000186890.1 ENSMUST00000186890.2 ENSMUST00000186890.3 ENSMUST00000186890.4 ENSMUST00000186890.5 ENSMUST00000186890.6 FJ541091 Gm20843 Gm20888 Gm20937 Gm21209 Gm21518 uc292uhx.1 uc292uhx.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292uhx.1 uc292uhx.2 
ENSMUST00000186892.7 Gm28170 ENSMUST00000186892.7 Gm28170 (from geneSymbol) DQ874391 ENSMUST00000186892.1 ENSMUST00000186892.2 ENSMUST00000186892.3 ENSMUST00000186892.4 ENSMUST00000186892.5 ENSMUST00000186892.6 uc009vfl.1 uc009vfl.2 uc009vfl.1 uc009vfl.2 
ENSMUST00000186895.2 Gm28982 ENSMUST00000186895.2 Gm28982 (from geneSymbol) ENSMUST00000186895.1 uc287iuc.1 uc287iuc.2 uc287iuc.1 uc287iuc.2 
ENSMUST00000186902.7 Gm28491 ENSMUST00000186902.7 Gm28491 (from geneSymbol) ENSMUST00000186902.1 ENSMUST00000186902.2 ENSMUST00000186902.3 ENSMUST00000186902.4 ENSMUST00000186902.5 ENSMUST00000186902.6 uc292sxd.1 uc292sxd.2 uc292sxd.1 uc292sxd.2 
ENSMUST00000186910.2 Gm20924 ENSMUST00000186910.2 predicted gene, 20924 (from RefSeq NM_001384236.1) ENSMUST00000186910.1 Gm20738 Gm20823 Gm20924 Gm21249 LOC382133 NM_001384236 Q810R8 Q810R8_MOUSE uc009vih.1 uc009vih.2 uc009vih.3 uc009vih.4 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc009vih.1 uc009vih.2 uc009vih.3 uc009vih.4 
ENSMUST00000186912.7 Gm28470 ENSMUST00000186912.7 Gm28470 (from geneSymbol) ENSMUST00000186912.1 ENSMUST00000186912.2 ENSMUST00000186912.3 ENSMUST00000186912.4 ENSMUST00000186912.5 ENSMUST00000186912.6 uc292tcc.1 uc292tcc.2 uc292tcc.1 uc292tcc.2 
ENSMUST00000186916.2 Gm28226 ENSMUST00000186916.2 Gm28226 (from geneSymbol) ENSMUST00000186916.1 uc292utw.1 uc292utw.2 uc292utw.1 uc292utw.2 
ENSMUST00000186918.2 Gm28775 ENSMUST00000186918.2 Gm28775 (from geneSymbol) ENSMUST00000186918.1 uc292teo.1 uc292teo.2 uc292teo.1 uc292teo.2 
ENSMUST00000186921.7 Gm28291 ENSMUST00000186921.7 Gm28291 (from geneSymbol) ENSMUST00000186921.1 ENSMUST00000186921.2 ENSMUST00000186921.3 ENSMUST00000186921.4 ENSMUST00000186921.5 ENSMUST00000186921.6 uc292tqt.1 uc292tqt.2 uc292tqt.1 uc292tqt.2 
ENSMUST00000186928.2 Gm10662 ENSMUST00000186928.2 predicted gene 10662 (from RefSeq NM_001201364.1) ENSMUST00000186928.1 Gm10662 Gm5891 NM_001201364 Q3UT86 Q3UT86_MOUSE uc009foc.1 uc009foc.2 uc009foc.3 uc009foc.4 uc009foc.5 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. nucleotide binding microtubule cytoskeleton organization molecular_function protein kinase activity protein serine/threonine kinase activity ATP binding cellular_component cytoplasm protein phosphorylation biological_process intracellular signal transduction tau-protein kinase activity uc009foc.1 uc009foc.2 uc009foc.3 uc009foc.4 uc009foc.5 
ENSMUST00000186938.7 Gm21518 ENSMUST00000186938.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WQA3) A0A087WQA3 A0A087WQA3_MOUSE ENSMUST00000186938.1 ENSMUST00000186938.2 ENSMUST00000186938.3 ENSMUST00000186938.4 ENSMUST00000186938.5 ENSMUST00000186938.6 FJ541091 Gm20843 Gm20888 Gm20937 Gm21209 Gm21518 uc292txl.1 uc292txl.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292txl.1 uc292txl.2 
ENSMUST00000186941.2 4921509O09Rik ENSMUST00000186941.2 4921509O09Rik (from geneSymbol) ENSMUST00000186941.1 NR_190453 uc292rzd.1 uc292rzd.2 uc292rzd.1 uc292rzd.2 
ENSMUST00000186955.4 1700019P21Rik ENSMUST00000186955.4 1700019P21Rik (from geneSymbol) AK006139 ENSMUST00000186955.1 ENSMUST00000186955.2 ENSMUST00000186955.3 uc007cvx.1 uc007cvx.2 uc007cvx.3 uc007cvx.4 uc007cvx.1 uc007cvx.2 uc007cvx.3 uc007cvx.4 
ENSMUST00000186967.2 Gm28709 ENSMUST00000186967.2 Gm28709 (from geneSymbol) ENSMUST00000186967.1 uc292tts.1 uc292tts.2 uc292tts.1 uc292tts.2 
ENSMUST00000186974.2 Gm21718 ENSMUST00000186974.2 Gm21718 (from geneSymbol) ENSMUST00000186974.1 uc288top.1 uc288top.2 uc288top.1 uc288top.2 
ENSMUST00000186977.3 2010009K17Rik ENSMUST00000186977.3 RIKEN cDNA 2010009K17 gene (from RefSeq NR_040609.1) ENSMUST00000186977.1 ENSMUST00000186977.2 NR_040609 uc008npq.1 uc008npq.2 uc008npq.3 uc008npq.4 uc008npq.5 uc008npq.1 uc008npq.2 uc008npq.3 uc008npq.4 uc008npq.5 
ENSMUST00000186990.2 Gm28972 ENSMUST00000186990.2 Gm28972 (from geneSymbol) ENSMUST00000186990.1 uc292uvy.1 uc292uvy.2 uc292uvy.1 uc292uvy.2 
ENSMUST00000186992.2 Gm28195 ENSMUST00000186992.2 Gm28195 (from geneSymbol) ENSMUST00000186992.1 uc292ijz.1 uc292ijz.2 uc292ijz.1 uc292ijz.2 
ENSMUST00000186996.7 Gm20855 ENSMUST00000186996.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE BC049626 ENSMUST00000186996.1 ENSMUST00000186996.2 ENSMUST00000186996.3 ENSMUST00000186996.4 ENSMUST00000186996.5 ENSMUST00000186996.6 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292tbd.1 uc292tbd.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292tbd.1 uc292tbd.2 
ENSMUST00000187002.2 Gm29393 ENSMUST00000187002.2 Gm29393 (from geneSymbol) ENSMUST00000187002.1 uc292uzj.1 uc292uzj.2 uc292uzj.1 uc292uzj.2 
ENSMUST00000187004.3 Gm28626 ENSMUST00000187004.3 predicted gene 28626 (from RefSeq NR_151592.1) ENSMUST00000187004.1 ENSMUST00000187004.2 NR_151592 uc287jzu.1 uc287jzu.2 uc287jzu.3 uc287jzu.1 uc287jzu.2 uc287jzu.3 
ENSMUST00000187008.2 Gm28652 ENSMUST00000187008.2 Gm28652 (from geneSymbol) ENSMUST00000187008.1 uc292jpr.1 uc292jpr.2 uc292jpr.1 uc292jpr.2 
ENSMUST00000187014.2 Gm29064 ENSMUST00000187014.2 Gm29064 (from geneSymbol) ENSMUST00000187014.1 uc290nvp.1 uc290nvp.2 uc290nvp.1 uc290nvp.2 
ENSMUST00000187015.7 4930579C12Rik ENSMUST00000187015.7 RIKEN cDNA 4930579C12 gene (from RefSeq NR_168074.1) ENSMUST00000187015.1 ENSMUST00000187015.2 ENSMUST00000187015.3 ENSMUST00000187015.4 ENSMUST00000187015.5 ENSMUST00000187015.6 NR_168074 uc029xfj.1 uc029xfj.2 uc029xfj.1 uc029xfj.2 
ENSMUST00000187019.8 Gm5420 ENSMUST00000187019.8 Gm5420 (from geneSymbol) AK090213 ENSMUST00000187019.1 ENSMUST00000187019.2 ENSMUST00000187019.3 ENSMUST00000187019.4 ENSMUST00000187019.5 ENSMUST00000187019.6 ENSMUST00000187019.7 uc287pyr.1 uc287pyr.2 uc287pyr.3 uc287pyr.1 uc287pyr.2 uc287pyr.3 
ENSMUST00000187025.2 Gm28250 ENSMUST00000187025.2 Gm28250 (from geneSymbol) ENSMUST00000187025.1 uc292stb.1 uc292stb.2 uc292stb.1 uc292stb.2 
ENSMUST00000187029.7 Gm28938 ENSMUST00000187029.7 Gm28938 (from geneSymbol) ENSMUST00000187029.1 ENSMUST00000187029.2 ENSMUST00000187029.3 ENSMUST00000187029.4 ENSMUST00000187029.5 ENSMUST00000187029.6 uc292sug.1 uc292sug.2 uc292sug.1 uc292sug.2 
ENSMUST00000187033.3 Gm28870 ENSMUST00000187033.3 Belongs to the XLR/SYCP3 family. (from UniProt A0A0A6YW38) A0A0A6YW38 A0A0A6YW38_MOUSE ENSMUST00000187033.1 ENSMUST00000187033.2 Gm28870 uc292tml.1 uc292tml.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292tml.1 uc292tml.2 
ENSMUST00000187043.8 Gm28326 ENSMUST00000187043.8 Gm28326 (from geneSymbol) DQ874392 ENSMUST00000187043.1 ENSMUST00000187043.2 ENSMUST00000187043.3 ENSMUST00000187043.4 ENSMUST00000187043.5 ENSMUST00000187043.6 ENSMUST00000187043.7 uc292tum.1 uc292tum.2 uc292tum.3 uc292tum.1 uc292tum.2 uc292tum.3 
ENSMUST00000187044.2 Gm21916 ENSMUST00000187044.2 Gm21916 (from geneSymbol) ENSMUST00000187044.1 FJ386436 uc292syv.1 uc292syv.2 uc292syv.1 uc292syv.2 
ENSMUST00000187045.2 Gm29839 ENSMUST00000187045.2 Gm29839 (from geneSymbol) ENSMUST00000187045.1 uc292tfh.1 uc292tfh.2 uc292tfh.1 uc292tfh.2 
ENSMUST00000187052.2 Gm28442 ENSMUST00000187052.2 Gm28442 (from geneSymbol) ENSMUST00000187052.1 uc292sbk.1 uc292sbk.2 uc292sbk.1 uc292sbk.2 
ENSMUST00000187076.7 4921514A10Rik ENSMUST00000187076.7 4921514A10Rik (from geneSymbol) AK132662 ENSMUST00000187076.1 ENSMUST00000187076.2 ENSMUST00000187076.3 ENSMUST00000187076.4 ENSMUST00000187076.5 ENSMUST00000187076.6 uc290ric.1 uc290ric.2 uc290ric.1 uc290ric.2 
ENSMUST00000187081.2 Scgb1b17 ENSMUST00000187081.2 secretoglobin, family 1B, member 17 (from RefSeq NM_001370878.1) A0A087WP50 A0A087WP50_MOUSE Abpa15_a17 ENSMUST00000187081.1 NM_001370878 Scgb1b15 Scgb1b17 uc291ohm.1 uc291ohm.2 Secreted steroid binding extracellular region biological_process uc291ohm.1 uc291ohm.2 
ENSMUST00000187087.2 Gm28774 ENSMUST00000187087.2 Gm28774 (from geneSymbol) ENSMUST00000187087.1 uc292tel.1 uc292tel.2 uc292tel.1 uc292tel.2 
ENSMUST00000187099.2 Gm28163 ENSMUST00000187099.2 Gm28163 (from geneSymbol) ENSMUST00000187099.1 uc290cok.1 uc290cok.2 uc290cok.1 uc290cok.2 
ENSMUST00000187100.2 Gm29114 ENSMUST00000187100.2 Gm29114 (from geneSymbol) AK040429 ENSMUST00000187100.1 uc287iyy.1 uc287iyy.2 uc287iyy.1 uc287iyy.2 
ENSMUST00000187110.2 Gm21780 ENSMUST00000187110.2 Gm21780 (from geneSymbol) ENSMUST00000187110.1 FJ386436 uc292sws.1 uc292sws.2 uc292sws.1 uc292sws.2 
ENSMUST00000187114.2 Gm28212 ENSMUST00000187114.2 Gm28212 (from geneSymbol) ENSMUST00000187114.1 uc292tdk.1 uc292tdk.2 uc292tdk.1 uc292tdk.2 
ENSMUST00000187118.2 Gm29672 ENSMUST00000187118.2 Gm29672 (from geneSymbol) ENSMUST00000187118.1 uc292tvi.1 uc292tvi.2 uc292tvi.1 uc292tvi.2 
ENSMUST00000187123.2 1700085C21Rik ENSMUST00000187123.2 RIKEN cDNA 1700085C21 gene (from RefSeq NR_046045.1) ENSMUST00000187123.1 NR_046045 uc029rua.1 uc029rua.2 uc029rua.1 uc029rua.2 
ENSMUST00000187127.2 Gm28199 ENSMUST00000187127.2 Gm28199 (from geneSymbol) ENSMUST00000187127.1 uc287kiu.1 uc287kiu.2 uc287kiu.1 uc287kiu.2 
ENSMUST00000187128.7 Gm28840 ENSMUST00000187128.7 Gm28840 (from geneSymbol) AK015935 ENSMUST00000187128.1 ENSMUST00000187128.2 ENSMUST00000187128.3 ENSMUST00000187128.4 ENSMUST00000187128.5 ENSMUST00000187128.6 uc292uih.1 uc292uih.2 uc292uih.1 uc292uih.2 
ENSMUST00000187129.2 Gm29193 ENSMUST00000187129.2 Gm29193 (from geneSymbol) ENSMUST00000187129.1 uc292sar.1 uc292sar.2 uc292sar.1 uc292sar.2 
ENSMUST00000187130.7 1700022A22Rik ENSMUST00000187130.7 1700022A22Rik (from geneSymbol) AK016801 ENSMUST00000187130.1 ENSMUST00000187130.2 ENSMUST00000187130.3 ENSMUST00000187130.4 ENSMUST00000187130.5 ENSMUST00000187130.6 uc029sow.1 uc029sow.2 uc029sow.3 uc029sow.1 uc029sow.2 uc029sow.3 
ENSMUST00000187133.2 Gm28147 ENSMUST00000187133.2 Gm28147 (from geneSymbol) ENSMUST00000187133.1 uc292sda.1 uc292sda.2 uc292sda.1 uc292sda.2 
ENSMUST00000187135.2 Gm20911 ENSMUST00000187135.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WSS0) A0A087WSS0 A0A087WSS0_MOUSE ENSMUST00000187135.1 Gm20911 uc292usw.1 uc292usw.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292usw.1 uc292usw.2 
ENSMUST00000187142.3 Zfp469 ENSMUST00000187142.3 zinc finger protein 469 (from RefSeq NM_001362883.2) A0A571BEL3 A0A571BEL3_MOUSE ENSMUST00000187142.1 ENSMUST00000187142.2 NM_001362883 Zfp469 uc292drz.1 uc292drz.2 uc292drz.3 uc292drz.1 uc292drz.2 uc292drz.3 
ENSMUST00000187146.2 Gm28102 ENSMUST00000187146.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WQL3) A0A087WQL3 A0A087WQL3_MOUSE BC100464 ENSMUST00000187146.1 Gm28102 uc292uyk.1 uc292uyk.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292uyk.1 uc292uyk.2 
ENSMUST00000187152.2 Gm29444 ENSMUST00000187152.2 Gm29444 (from geneSymbol) ENSMUST00000187152.1 uc292tir.1 uc292tir.2 uc292tir.1 uc292tir.2 
ENSMUST00000187154.2 Gm29529 ENSMUST00000187154.2 Gm29529 (from geneSymbol) ENSMUST00000187154.1 uc287mqy.1 uc287mqy.2 uc287mqy.1 uc287mqy.2 
ENSMUST00000187155.7 Ppp4r4 ENSMUST00000187155.7 Putative regulatory subunit of serine/threonine-protein phosphatase 4. (from UniProt Q8C0Y0) AK173221 E9QKU6 ENSMUST00000187155.1 ENSMUST00000187155.2 ENSMUST00000187155.3 ENSMUST00000187155.4 ENSMUST00000187155.5 ENSMUST00000187155.6 Kiaa1622 PP4R4_MOUSE Pp4r4 Q14CI7 Q14DT1 Q69ZE5 Q8C0Y0 Q9CRR0 uc288ivt.1 uc288ivt.2 Putative regulatory subunit of serine/threonine-protein phosphatase 4. Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R4 (By similarity). Cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C0Y0-1; Sequence=Displayed; Name=2; IsoId=Q8C0Y0-2; Sequence=VSP_029619, VSP_029620; Name=3; IsoId=Q8C0Y0-3; Sequence=VSP_029618; [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=BAD32499.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; blastocyst hatching protein binding cytoplasm cytosol protein serine/threonine phosphatase complex protein phosphatase regulator activity negative regulation of phosphoprotein phosphatase activity regulation of protein serine/threonine phosphatase activity uc288ivt.1 uc288ivt.2 
ENSMUST00000187157.7 Scgb3a2 ENSMUST00000187157.7 secretoglobin, family 3A, member 2, transcript variant 2 (from RefSeq NM_001289644.1) ENSMUST00000187157.1 ENSMUST00000187157.2 ENSMUST00000187157.3 ENSMUST00000187157.4 ENSMUST00000187157.5 ENSMUST00000187157.6 NM_001289644 Pnsp1 Q5D060 Q920H1 Q920H2 Q920H3 SG3A2_MOUSE Ugrp1 uc008eun.1 uc008eun.2 uc008eun.3 uc008eun.4 Secreted cytokine-like protein (By similarity). Binds to the scavenger receptor MARCO (By similarity). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram- negative bacterium P.aeruginosa, and yeast (By similarity). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919). Seems to have anti-inflammatory effects in respiratory epithelium (PubMed:16456148, PubMed:25242865). Also has anti-fibrotic activity in lung (PubMed:24213919, PubMed:26559674). May play a role in fetal lung development and maturation (PubMed:18535256). Promotes branching morphogenesis during early stages of lung development (PubMed:18535256). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (PubMed:24514953). Homodimer; disulfide-linked (PubMed:11682631, PubMed:24213919). Monomer (PubMed:11682631, PubMed:24213919). Interacts with APOA1 (By similarity). Secreted Event=Alternative splicing; Named isoforms=3; Name=A ; IsoId=Q920H1-2; Sequence=Displayed; Name=B ; IsoId=Q920H1-3; Sequence=VSP_059182; Name=C ; IsoId=Q920H1-1; Sequence=VSP_059183; Highly expressed in lung where it localizes to epithelial cells of the trachea, bronchus and bronchioles (at protein level) (PubMed:11682631, PubMed:12406855, PubMed:12175512, PubMed:25242865). Expressed in club cells of the bronchioles (PubMed:12406855). Also detected in the anterior and posterior lobes of the pituitary gland where it may localize to gonadotropic cells (at protein level) (PubMed:24514953). Not detected in other tissues tested (PubMed:11682631, PubMed:12175512). Detected in the pituitary gland from postnatal day 1 onwards (at protein level) (PubMed:24514953). Weakly expressed in embryonic lung at stages 11.5 dpc and 12.5 dpc (PubMed:11682631, PubMed:18535256). Seems to localize most strongly to the growing tips of bronchi at stage 13.5 dpc (PubMed:18535256). Highly expressed in developing lung at stages 16.5 dpc and 18.5 dpc, where it localizes to airway epithelia (PubMed:11682631, PubMed:12406855, PubMed:12175512, PubMed:24514953). During gestation, detected in the mammary gland at 6.5 days post coitum (dpc), but expression declines at 8.5 dpc and is absent at later stages (PubMed:12175512). Viable and fertile, with no gross abnormalities. Lung tissue appears normal (PubMed:25242865). In a C57BL/6NCr strain background, animals show a mild increase in ovalbumin-induced inflammatory response in lung (PubMed:25242865). However, in a mixed genetic background, there is a reduced ovalbumin-induced inflammatory response, possibly due to the presence of modifier genes (PubMed:25242865). Animals have a more severe response to bleomycin- induced pulmonary fibrosis characterized by increased weight loss, more extensive fibrosis in lung tissue, increased expression of collagen genes, higher numbers of lymphocyte, monocyte and neutrophil cells in bronchoalveolar lavage fluid, and increased cytokine levels (PubMed:26559674). [Isoform A]: Major isoform. Belongs to the secretoglobin family. UGRP subfamily. protein binding extracellular region extracellular space biological_process uc008eun.1 uc008eun.2 uc008eun.3 uc008eun.4 
ENSMUST00000187158.3 1700040F17Rik ENSMUST00000187158.3 1700040F17Rik (from geneSymbol) AK006654 ENSMUST00000187158.1 ENSMUST00000187158.2 uc288ybv.1 uc288ybv.2 uc288ybv.3 uc288ybv.1 uc288ybv.2 uc288ybv.3 
ENSMUST00000187165.2 Gm28827 ENSMUST00000187165.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WP44) A0A087WP44 A0A087WP44_MOUSE ENSMUST00000187165.1 Gm21760 Gm28827 Gm28897 Gm29110 Gm29564 Gm31571 uc292uud.1 uc292uud.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292uud.1 uc292uud.2 
ENSMUST00000187174.7 Gm28073 ENSMUST00000187174.7 Gm28073 (from geneSymbol) ENSMUST00000187174.1 ENSMUST00000187174.2 ENSMUST00000187174.3 ENSMUST00000187174.4 ENSMUST00000187174.5 ENSMUST00000187174.6 uc292tuy.1 uc292tuy.2 uc292tuy.1 uc292tuy.2 
ENSMUST00000187181.2 Gm28587 ENSMUST00000187181.2 Gm28587 (from geneSymbol) AK047561 ENSMUST00000187181.1 uc292rvk.1 uc292rvk.2 uc292rvk.1 uc292rvk.2 
ENSMUST00000187183.7 Csta2 ENSMUST00000187183.7 cystatin A family member 2, transcript variant 2 (from RefSeq NM_029733.3) 2010005H15Rik Csta2 ENSMUST00000187183.1 ENSMUST00000187183.2 ENSMUST00000187183.3 ENSMUST00000187183.4 ENSMUST00000187183.5 ENSMUST00000187183.6 NM_029733 Q9D8D6 Q9D8D6_MOUSE uc007zcj.1 uc007zcj.2 uc007zcj.3 uc007zcj.4 Belongs to the cystatin family. cornified envelope protease binding endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular space nucleus cytoplasm cytosol negative regulation of endopeptidase activity uc007zcj.1 uc007zcj.2 uc007zcj.3 uc007zcj.4 
ENSMUST00000187192.2 Gm29653 ENSMUST00000187192.2 Gm29653 (from geneSymbol) ENSMUST00000187192.1 uc292tah.1 uc292tah.2 uc292tah.1 uc292tah.2 
ENSMUST00000187196.7 Idi2l ENSMUST00000187196.7 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (from UniProt Q8BFZ6) ENSMUST00000187196.1 ENSMUST00000187196.2 ENSMUST00000187196.3 ENSMUST00000187196.4 ENSMUST00000187196.5 ENSMUST00000187196.6 Gm9745 IDI2_MOUSE Idi2 Q4FZF0 Q8BFZ6 uc288koc.1 uc288koc.2 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Reaction=isopentenyl diphosphate = dimethylallyl diphosphate; Xref=Rhea:RHEA:23284, ChEBI:CHEBI:57623, ChEBI:CHEBI:128769; EC=5.3.3.2; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1. Peroxisome Belongs to the IPP isomerase type 1 family. isopentenyl-diphosphate delta-isomerase activity peroxisome lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process steroid metabolic process cholesterol metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process sterol biosynthetic process hydrolase activity isomerase activity negative regulation of cholesterol biosynthetic process isopentenyl diphosphate metabolic process metal ion binding dimethylallyl diphosphate biosynthetic process uc288koc.1 uc288koc.2 
ENSMUST00000187198.2 Gm29374 ENSMUST00000187198.2 Gm29374 (from geneSymbol) ENSMUST00000187198.1 uc287kbx.1 uc287kbx.2 uc287kbx.1 uc287kbx.2 
ENSMUST00000187200.2 Gm28317 ENSMUST00000187200.2 Gm28317 (from geneSymbol) ENSMUST00000187200.1 uc292tnm.1 uc292tnm.2 uc292tnm.1 uc292tnm.2 
ENSMUST00000187201.7 Gm29368 ENSMUST00000187201.7 Gm29368 (from geneSymbol) ENSMUST00000187201.1 ENSMUST00000187201.2 ENSMUST00000187201.3 ENSMUST00000187201.4 ENSMUST00000187201.5 ENSMUST00000187201.6 uc292tut.1 uc292tut.2 uc292tut.1 uc292tut.2 
ENSMUST00000187203.7 Gm28687 ENSMUST00000187203.7 Gm28687 (from geneSymbol) DQ874392 ENSMUST00000187203.1 ENSMUST00000187203.2 ENSMUST00000187203.3 ENSMUST00000187203.4 ENSMUST00000187203.5 ENSMUST00000187203.6 uc292twf.1 uc292twf.2 uc292twf.1 uc292twf.2 
ENSMUST00000187204.2 Gm29405 ENSMUST00000187204.2 Gm29405 (from geneSymbol) ENSMUST00000187204.1 uc292ttg.1 uc292ttg.2 uc292ttg.1 uc292ttg.2 
ENSMUST00000187206.2 Gm29628 ENSMUST00000187206.2 Gm29628 (from geneSymbol) ENSMUST00000187206.1 uc292tyy.1 uc292tyy.2 uc292tyy.1 uc292tyy.2 
ENSMUST00000187209.2 Gm29302 ENSMUST00000187209.2 Gm29302 (from geneSymbol) ENSMUST00000187209.1 uc292uxd.1 uc292uxd.2 uc292uxd.1 uc292uxd.2 
ENSMUST00000187215.2 Gm29331 ENSMUST00000187215.2 Gm29331 (from geneSymbol) ENSMUST00000187215.1 uc289bbl.1 uc289bbl.2 uc289bbl.1 uc289bbl.2 
ENSMUST00000187224.2 Gm29219 ENSMUST00000187224.2 Gm29219 (from geneSymbol) ENSMUST00000187224.1 uc292udt.1 uc292udt.2 uc292udt.1 uc292udt.2 
ENSMUST00000187228.2 Gm28786 ENSMUST00000187228.2 Gm28786 (from geneSymbol) ENSMUST00000187228.1 uc292tex.1 uc292tex.2 uc292tex.1 uc292tex.2 
ENSMUST00000187236.2 Gm29656 ENSMUST00000187236.2 Gm29656 (from geneSymbol) ENSMUST00000187236.1 uc292tae.1 uc292tae.2 uc292tae.1 uc292tae.2 
ENSMUST00000187241.3 Zfp932 ENSMUST00000187241.3 zinc finger protein 932, transcript variant 1 (from RefSeq NM_145563.2) E9QAG8 ENSMUST00000187241.1 ENSMUST00000187241.2 NM_145563 ZN431_MOUSE Zfp431 Znf431 uc290ycp.1 uc290ycp.2 uc290ycp.3 Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1. Interacts (via KRAB domain) with HDAC2; the interaction is direct. Interacts (via KRAB domain) with HDAC1. E9QAG8; O09106: Hdac1; NbExp=3; IntAct=EBI-9549639, EBI-301912; E9QAG8; P70288: Hdac2; NbExp=3; IntAct=EBI-9549639, EBI-302251; Nucleus Expressed in brain, heart, lung, thymus, spleen, lymph node, liver, kidney, muscle, testis, ovary, skin and uterus. Expressed in limb mesenchyme at 10.5 dpc. Expressed in tooth, submandibular glands, thymus, thyroid, vibrissa follicles at 14.5 dpc. The KRAB domain is necessary for its repressive activity. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleic acid binding chromatin binding protein binding nucleus regulation of transcription, DNA-templated cell differentiation histone deacetylase binding negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of osteoblast differentiation metal ion binding uc290ycp.1 uc290ycp.2 uc290ycp.3 
ENSMUST00000187245.2 Gm20737 ENSMUST00000187245.2 Belongs to the SPIN/STSY family. (from UniProt Q3TTD8) ENSMUST00000187245.1 Gm20737 Gm20772 Gm20777 Gm20793 Gm20831 Gm21425 Gm21440 Q3TTD8 Q3TTD8_MOUSE uc292sfe.1 uc292sfe.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sfe.1 uc292sfe.2 
ENSMUST00000187257.2 Scgb1b10 ENSMUST00000187257.2 Secreted (from UniProt A0A087WPW0) A0A087WPW0 A0A087WPW0_MOUSE Abpa10 ENSMUST00000187257.1 Scgb1b10 uc291ofz.1 uc291ofz.2 Secreted steroid binding extracellular region biological_process uc291ofz.1 uc291ofz.2 
ENSMUST00000187258.2 Gm29547 ENSMUST00000187258.2 Gm29547 (from geneSymbol) ENSMUST00000187258.1 uc292txu.1 uc292txu.2 uc292txu.1 uc292txu.2 
ENSMUST00000187266.7 Gm28089 ENSMUST00000187266.7 Gm28089 (from geneSymbol) ENSMUST00000187266.1 ENSMUST00000187266.2 ENSMUST00000187266.3 ENSMUST00000187266.4 ENSMUST00000187266.5 ENSMUST00000187266.6 uc292swb.1 uc292swb.2 uc292swb.1 uc292swb.2 
ENSMUST00000187274.2 Gm28242 ENSMUST00000187274.2 Gm28242 (from geneSymbol) ENSMUST00000187274.1 uc292rza.1 uc292rza.2 uc292rza.1 uc292rza.2 
ENSMUST00000187280.2 Gm28054 ENSMUST00000187280.2 Gm28054 (from geneSymbol) ENSMUST00000187280.1 uc292jrb.1 uc292jrb.2 uc292jrb.1 uc292jrb.2 
ENSMUST00000187285.7 Plekha6 ENSMUST00000187285.7 Plekha6 (from geneSymbol) A0A087WRB7 A0A087WRB7_MOUSE BC054547 ENSMUST00000187285.1 ENSMUST00000187285.2 ENSMUST00000187285.3 ENSMUST00000187285.4 ENSMUST00000187285.5 ENSMUST00000187285.6 Plekha6 uc287ltj.1 uc287ltj.2 uc287ltj.1 uc287ltj.2 
ENSMUST00000187288.2 Gm21821 ENSMUST00000187288.2 Gm21821 (from geneSymbol) ENSMUST00000187288.1 uc292sxv.1 uc292sxv.2 uc292sxv.1 uc292sxv.2 
ENSMUST00000187289.2 Gm29091 ENSMUST00000187289.2 Gm29091 (from geneSymbol) ENSMUST00000187289.1 uc292uxj.1 uc292uxj.2 uc292uxj.1 uc292uxj.2 
ENSMUST00000187292.7 Gm29399 ENSMUST00000187292.7 Gm29399 (from geneSymbol) ENSMUST00000187292.1 ENSMUST00000187292.2 ENSMUST00000187292.3 ENSMUST00000187292.4 ENSMUST00000187292.5 ENSMUST00000187292.6 uc292stu.1 uc292stu.2 uc292stu.1 uc292stu.2 
ENSMUST00000187293.7 Gm20931 ENSMUST00000187293.7 predicted gene, 20931 (from RefSeq NM_001373881.1) A0A087WRK1 A0A087WRK1_MOUSE ENSMUST00000187293.1 ENSMUST00000187293.2 ENSMUST00000187293.3 ENSMUST00000187293.4 ENSMUST00000187293.5 ENSMUST00000187293.6 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 NM_001373881 Sly uc009vha.1 uc009vha.2 uc009vha.3 uc009vha.4 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc009vha.1 uc009vha.2 uc009vha.3 uc009vha.4 
ENSMUST00000187298.2 Gm28866 ENSMUST00000187298.2 Gm28866 (from geneSymbol) ENSMUST00000187298.1 uc292uyr.1 uc292uyr.2 uc292uyr.1 uc292uyr.2 
ENSMUST00000187304.2 Prr30 ENSMUST00000187304.2 Prr30 (from geneSymbol) E9QQ59 ENSMUST00000187304.1 PRR30_MOUSE Q9D9B7 uc033gsj.1 uc033gsj.2 uc033gsj.3 molecular_function cellular_component biological_process uc033gsj.1 uc033gsj.2 uc033gsj.3 
ENSMUST00000187317.7 Cacna1c ENSMUST00000187317.7 Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. (from UniProt A0A087WRM3) A0A087WRM3 A0A087WRM3_MOUSE Cacna1c ENSMUST00000187317.1 ENSMUST00000187317.2 ENSMUST00000187317.3 ENSMUST00000187317.4 ENSMUST00000187317.5 ENSMUST00000187317.6 FM872414 uc291igt.1 uc291igt.2 Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Cell membrane, sarcolemma, T-tubule Cell membrane, sarcolemma ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Cell projection, dendrite Membrane ; Multi- pass membrane protein rikaryon Postsynaptic density membrane Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. ion channel activity voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity voltage-gated calcium channel complex ion transport calcium ion transport membrane integral component of membrane regulation of ion transmembrane transport transmembrane transport calcium ion transmembrane transport uc291igt.1 uc291igt.2 
ENSMUST00000187332.2 Gm29245 ENSMUST00000187332.2 Gm29245 (from geneSymbol) ENSMUST00000187332.1 uc287qvt.1 uc287qvt.2 uc287qvt.1 uc287qvt.2 
ENSMUST00000187337.7 Gm28260 ENSMUST00000187337.7 Gm28260 (from geneSymbol) ENSMUST00000187337.1 ENSMUST00000187337.2 ENSMUST00000187337.3 ENSMUST00000187337.4 ENSMUST00000187337.5 ENSMUST00000187337.6 uc292tbn.1 uc292tbn.2 uc292tbn.1 uc292tbn.2 
ENSMUST00000187343.3 1700084E18Rik ENSMUST00000187343.3 1700084E18Rik (from geneSymbol) ENSMUST00000187343.1 ENSMUST00000187343.2 LF193233 uc008jbt.1 uc008jbt.2 uc008jbt.3 uc008jbt.4 uc008jbt.5 uc008jbt.1 uc008jbt.2 uc008jbt.3 uc008jbt.4 uc008jbt.5 
ENSMUST00000187344.2 Gm28616 ENSMUST00000187344.2 Gm28616 (from geneSymbol) ENSMUST00000187344.1 uc291aig.1 uc291aig.2 uc291aig.1 uc291aig.2 
ENSMUST00000187349.2 Gm28450 ENSMUST00000187349.2 Gm28450 (from geneSymbol) ENSMUST00000187349.1 uc290bga.1 uc290bga.2 uc290bga.1 uc290bga.2 
ENSMUST00000187350.2 Gm28886 ENSMUST00000187350.2 Gm28886 (from geneSymbol) ENSMUST00000187350.1 FJ386436 uc292tik.1 uc292tik.2 uc292tik.1 uc292tik.2 
ENSMUST00000187351.2 Gm28967 ENSMUST00000187351.2 Gm28967 (from geneSymbol) AF357346 ENSMUST00000187351.1 uc291jad.1 uc291jad.2 uc291jad.1 uc291jad.2 
ENSMUST00000187355.7 Gm29203 ENSMUST00000187355.7 Gm29203 (from geneSymbol) ENSMUST00000187355.1 ENSMUST00000187355.2 ENSMUST00000187355.3 ENSMUST00000187355.4 ENSMUST00000187355.5 ENSMUST00000187355.6 uc292tww.1 uc292tww.2 uc292tww.1 uc292tww.2 
ENSMUST00000187361.4 4933429H19Rik ENSMUST00000187361.4 4933429H19Rik (from geneSymbol) ENSMUST00000187361.1 ENSMUST00000187361.2 ENSMUST00000187361.3 LF193878 uc290ehv.1 uc290ehv.2 uc290ehv.3 uc290ehv.1 uc290ehv.2 uc290ehv.3 
ENSMUST00000187366.2 Gm29093 ENSMUST00000187366.2 Gm29093 (from geneSymbol) ENSMUST00000187366.1 uc287tax.1 uc287tax.2 uc287tax.1 uc287tax.2 
ENSMUST00000187369.7 Fam135a ENSMUST00000187369.7 family with sequence similarity 135, member A, transcript variant 12 (from RefSeq NM_001403097.1) A0A087WRT5 A0A087WRT5_MOUSE ENSMUST00000187369.1 ENSMUST00000187369.2 ENSMUST00000187369.3 ENSMUST00000187369.4 ENSMUST00000187369.5 ENSMUST00000187369.6 Fam135a NM_001403097 uc287gwi.1 uc287gwi.2 Belongs to the FAM135 family. uc287gwi.1 uc287gwi.2 
ENSMUST00000187370.3 Gm29099 ENSMUST00000187370.3 Gm29099 (from geneSymbol) ENSMUST00000187370.1 ENSMUST00000187370.2 uc287klp.1 uc287klp.2 uc287klp.3 uc287klp.1 uc287klp.2 uc287klp.3 
ENSMUST00000187372.2 Gm28725 ENSMUST00000187372.2 Gm28725 (from geneSymbol) DQ874391 ENSMUST00000187372.1 uc292suv.1 uc292suv.2 uc292suv.1 uc292suv.2 
ENSMUST00000187378.2 Gm29507 ENSMUST00000187378.2 Gm29507 (from geneSymbol) AK050715 ENSMUST00000187378.1 uc291upu.1 uc291upu.2 uc291upu.1 uc291upu.2 
ENSMUST00000187381.2 Gm21599 ENSMUST00000187381.2 Gm21599 (from geneSymbol) ENSMUST00000187381.1 FJ386436 uc292syq.1 uc292syq.2 uc292syq.1 uc292syq.2 
ENSMUST00000187384.2 Gm29204 ENSMUST00000187384.2 Gm29204 (from geneSymbol) ENSMUST00000187384.1 uc292twm.1 uc292twm.2 uc292twm.1 uc292twm.2 
ENSMUST00000187385.2 Gm28426 ENSMUST00000187385.2 Gm28426 (from geneSymbol) ENSMUST00000187385.1 uc292tgw.1 uc292tgw.2 uc292tgw.1 uc292tgw.2 
ENSMUST00000187387.2 Gm28681 ENSMUST00000187387.2 Gm28681 (from geneSymbol) ENSMUST00000187387.1 uc292tmc.1 uc292tmc.2 uc292tmc.1 uc292tmc.2 
ENSMUST00000187391.7 1700029H14Rik ENSMUST00000187391.7 RIKEN cDNA 1700029H14 gene, transcript variant 2 (from RefSeq NM_001080781.2) 1700029H14Rik ENSMUST00000187391.1 ENSMUST00000187391.2 ENSMUST00000187391.3 ENSMUST00000187391.4 ENSMUST00000187391.5 ENSMUST00000187391.6 G3X906 G3X906_MOUSE NM_001080781 uc009kyc.1 uc009kyc.2 uc009kyc.3 uc009kyc.4 molecular_function cellular_component biological_process uc009kyc.1 uc009kyc.2 uc009kyc.3 uc009kyc.4 
ENSMUST00000187393.4 Gm28424 ENSMUST00000187393.4 Gm28424 (from geneSymbol) ENSMUST00000187393.1 ENSMUST00000187393.2 ENSMUST00000187393.3 LF197738 uc292jsb.1 uc292jsb.2 uc292jsb.3 uc292jsb.4 uc292jsb.1 uc292jsb.2 uc292jsb.3 uc292jsb.4 
ENSMUST00000187402.7 Gm28088 ENSMUST00000187402.7 Gm28088 (from geneSymbol) ENSMUST00000187402.1 ENSMUST00000187402.2 ENSMUST00000187402.3 ENSMUST00000187402.4 ENSMUST00000187402.5 ENSMUST00000187402.6 uc292swe.1 uc292swe.2 uc292swe.1 uc292swe.2 
ENSMUST00000187403.2 Gm28128 ENSMUST00000187403.2 Gm28128 (from geneSymbol) ENSMUST00000187403.1 FJ386436 uc292svg.1 uc292svg.2 uc292svg.1 uc292svg.2 
ENSMUST00000187408.2 Gm21450 ENSMUST00000187408.2 Gm21450 (from geneSymbol) ENSMUST00000187408.1 uc292tvr.1 uc292tvr.2 uc292tvr.1 uc292tvr.2 
ENSMUST00000187409.3 Gm7854 ENSMUST00000187409.3 predicted gene 7854 (from RefSeq NR_028417.2) ENSMUST00000187409.1 ENSMUST00000187409.2 NR_028417 uc008xhh.1 uc008xhh.2 uc008xhh.3 uc008xhh.4 uc008xhh.1 uc008xhh.2 uc008xhh.3 uc008xhh.4 
ENSMUST00000187410.7 Il19 ENSMUST00000187410.7 interleukin 19, transcript variant 1 (from RefSeq NM_001009940.2) ENSMUST00000187410.1 ENSMUST00000187410.2 ENSMUST00000187410.3 ENSMUST00000187410.4 ENSMUST00000187410.5 ENSMUST00000187410.6 IL19_MOUSE NM_001009940 Q8CJ70 uc007cms.1 uc007cms.2 uc007cms.3 Cytokine that functions as an anti-inflammatory and proangiogenic factor (PubMed:12370360, PubMed:27053520). Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up- regulation of IL4 and IL5 (PubMed:15557163). Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (PubMed:33684929). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB. In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3 (By similarity). Secreted. IL19-deficient mice are more susceptible to innate-mediated colitis and develop more severe inflammation in response to injury (PubMed:19834971). In addition, mice respond to vascular endothelial growth factor (VEGF) significantly less than wild- type mice (PubMed:27053520). Belongs to the IL-10 family. cytokine activity extracellular region extracellular space apoptotic process signal transduction negative regulation of low-density lipoprotein particle clearance interleukin-6 biosynthetic process reactive oxygen species metabolic process positive regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway uc007cms.1 uc007cms.2 uc007cms.3 
ENSMUST00000187415.3 Gm28512 ENSMUST00000187415.3 Gm28512 (from geneSymbol) ENSMUST00000187415.1 ENSMUST00000187415.2 uc287mrc.1 uc287mrc.2 uc287mrc.3 uc287mrc.1 uc287mrc.2 uc287mrc.3 
ENSMUST00000187416.2 ENSMUSG00000121282 ENSMUST00000187416.2 ENSMUSG00000121282 (from geneSymbol) ENSMUST00000187416.1 uc292ufu.1 uc292ufu.2 uc292ufu.1 uc292ufu.2 
ENSMUST00000187418.2 Gm21118 ENSMUST00000187418.2 Belongs to the SPIN/STSY family. (from UniProt J3QPK8) ENSMUST00000187418.1 Gm21118 J3QPK8 J3QPK8_MOUSE uc292uhi.1 uc292uhi.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292uhi.1 uc292uhi.2 
ENSMUST00000187419.7 Gm28207 ENSMUST00000187419.7 Gm28207 (from geneSymbol) ENSMUST00000187419.1 ENSMUST00000187419.2 ENSMUST00000187419.3 ENSMUST00000187419.4 ENSMUST00000187419.5 ENSMUST00000187419.6 uc292tsr.1 uc292tsr.2 uc292tsr.1 uc292tsr.2 
ENSMUST00000187426.2 Gm29434 ENSMUST00000187426.2 Gm29434 (from geneSymbol) ENSMUST00000187426.1 uc290owl.1 uc290owl.2 uc290owl.1 uc290owl.2 
ENSMUST00000187433.7 Gm21760 ENSMUST00000187433.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WP44) A0A087WP44 A0A087WP44_MOUSE ENSMUST00000187433.1 ENSMUST00000187433.2 ENSMUST00000187433.3 ENSMUST00000187433.4 ENSMUST00000187433.5 ENSMUST00000187433.6 Gm21760 Gm28827 Gm28897 Gm29110 Gm29564 Gm31571 uc292urz.1 uc292urz.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292urz.1 uc292urz.2 
ENSMUST00000187434.2 Gm20777 ENSMUST00000187434.2 Belongs to the SPIN/STSY family. (from UniProt Q3TTD8) ENSMUST00000187434.1 Gm20737 Gm20772 Gm20777 Gm20793 Gm20831 Gm21425 Gm21440 Q3TTD8 Q3TTD8_MOUSE uc292sfo.1 uc292sfo.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sfo.1 uc292sfo.2 
ENSMUST00000187441.2 Gm28689 ENSMUST00000187441.2 Gm28689 (from geneSymbol) ENSMUST00000187441.1 uc292twe.1 uc292twe.2 uc292twe.1 uc292twe.2 
ENSMUST00000187443.2 Gm28355 ENSMUST00000187443.2 Gm28355 (from geneSymbol) ENSMUST00000187443.1 uc292tsa.1 uc292tsa.2 uc292tsa.1 uc292tsa.2 
ENSMUST00000187450.2 Gm28277 ENSMUST00000187450.2 Gm28277 (from geneSymbol) ENSMUST00000187450.1 uc287lzw.1 uc287lzw.2 uc287lzw.1 uc287lzw.2 
ENSMUST00000187452.2 Gm29234 ENSMUST00000187452.2 Gm29234 (from geneSymbol) ENSMUST00000187452.1 uc289zjl.1 uc289zjl.2 uc289zjl.1 uc289zjl.2 
ENSMUST00000187453.2 Gm28746 ENSMUST00000187453.2 Gm28746 (from geneSymbol) ENSMUST00000187453.1 uc291rjo.1 uc291rjo.2 uc291rjo.1 uc291rjo.2 
ENSMUST00000187458.4 2510046G10Rik ENSMUST00000187458.4 2510046G10Rik (from geneSymbol) AK020571 ENSMUST00000187458.1 ENSMUST00000187458.2 ENSMUST00000187458.3 uc291vls.1 uc291vls.2 uc291vls.3 uc291vls.4 uc291vls.1 uc291vls.2 uc291vls.3 uc291vls.4 
ENSMUST00000187467.2 Ms4a14 ENSMUST00000187467.2 membrane-spanning 4-domains, subfamily A, member 14 (from RefSeq NM_001377045.1) A0A087WSD2 A0A087WSD2_MOUSE ENSMUST00000187467.1 Ms4a14 NM_001377045 uc289qye.1 uc289qye.2 Belongs to the MS4A family. molecular_function cellular_component biological_process membrane integral component of membrane uc289qye.1 uc289qye.2 
ENSMUST00000187477.2 Gm20920 ENSMUST00000187477.2 X-linked lymphocyte-regulated protein PM1-like (from RefSeq NM_001378759.1) A0A087WRK1 A0A087WRK1_MOUSE ENSMUST00000187477.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 NM_001378759 Sly uc292tog.1 uc292tog.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292tog.1 uc292tog.2 
ENSMUST00000187482.2 Rbmyf1 ENSMUST00000187482.2 RNA binding motif protein Y-linked family member 1 (from RefSeq NM_001270518.1) A0A087WR82 A0A087WR82_MOUSE ENSMUST00000187482.1 Gm4064 NM_001270518 Rbmyf1 uc012hrx.1 uc012hrx.2 uc012hrx.3 uc012hrx.4 Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. nucleic acid binding RNA binding nucleus spliceosomal complex positive regulation of mRNA splicing, via spliceosome ribonucleoprotein complex uc012hrx.1 uc012hrx.2 uc012hrx.3 uc012hrx.4 
ENSMUST00000187484.2 Gm29053 ENSMUST00000187484.2 Gm29053 (from geneSymbol) ENSMUST00000187484.1 uc289zbh.1 uc289zbh.2 uc289zbh.1 uc289zbh.2 
ENSMUST00000187496.2 Gm28824 ENSMUST00000187496.2 Gm28824 (from geneSymbol) ENSMUST00000187496.1 uc292ugq.1 uc292ugq.2 uc292ugq.1 uc292ugq.2 
ENSMUST00000187502.2 Gm28674 ENSMUST00000187502.2 Gm28674 (from geneSymbol) ENSMUST00000187502.1 uc292uzu.1 uc292uzu.2 uc292uzu.1 uc292uzu.2 
ENSMUST00000187504.7 Lbhd1 ENSMUST00000187504.7 LBH domain containing 1 (from RefSeq NM_001286103.1) A0A087WPA0 A0A087WPA0_MOUSE ENSMUST00000187504.1 ENSMUST00000187504.2 ENSMUST00000187504.3 ENSMUST00000187504.4 ENSMUST00000187504.5 ENSMUST00000187504.6 Lbhd1 NM_001286103 uc033hjc.1 uc033hjc.2 uc033hjc.3 This gene shares three exons in common with another gene, the RIKEN cDNA 1810009A15 gene (GeneID:66276), but the encoded protein uses a reading frame that is different from that of the RIKEN cDNA 1810009A15 gene. [provided by RefSeq, Nov 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BQ954738.1, BI734830.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## uc033hjc.1 uc033hjc.2 uc033hjc.3 
ENSMUST00000187506.2 Gm28971 ENSMUST00000187506.2 Gm28971 (from geneSymbol) ENSMUST00000187506.1 uc292uwa.1 uc292uwa.2 uc292uwa.1 uc292uwa.2 
ENSMUST00000187510.7 Chrm3 ENSMUST00000187510.7 cholinergic receptor, muscarinic 3, cardiac (from RefSeq NM_033269.4) ACM3_MOUSE Chrm-3 ENSMUST00000187510.1 ENSMUST00000187510.2 ENSMUST00000187510.3 ENSMUST00000187510.4 ENSMUST00000187510.5 ENSMUST00000187510.6 NM_033269 Q64055 Q9ERZ3 uc007plb.1 uc007plb.2 uc007plb.3 The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Homodimer; the dimers can form tetramers (By similarity). Interacts with NALCN (PubMed:19575010). Interacts with TMEM147 (By similarity). Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane. Expressed in cerebral cortex, submandibular gland, hypothalamus, pancreas, liver, and ileum. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily. regulation of vascular smooth muscle contraction G-protein coupled receptor activity G-protein coupled serotonin receptor activity protein binding plasma membrane integral component of plasma membrane smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway G-protein coupled acetylcholine receptor signaling pathway chemical synaptic transmission synaptic transmission, cholinergic drug binding membrane integral component of membrane basolateral plasma membrane G-protein coupled acetylcholine receptor activity regulation of vasoconstriction cell junction dendrite neurotransmitter receptor activity asymmetric synapse acetylcholine binding axon terminus synapse postsynaptic membrane positive regulation of smooth muscle contraction saliva secretion glutamatergic synapse integral component of presynaptic membrane integral component of postsynaptic density membrane positive regulation of vascular smooth muscle contraction uc007plb.1 uc007plb.2 uc007plb.3 
ENSMUST00000187512.2 Krtap5-3 ENSMUST00000187512.2 keratin associated protein 5-3 (from RefSeq NM_023860.1) A0A087WSN0 A0A087WSN0_MOUSE ENSMUST00000187512.1 Krtap5-3 NM_023860 uc012fxj.1 uc012fxj.2 keratin filament uc012fxj.1 uc012fxj.2 
ENSMUST00000187519.7 Fam227a ENSMUST00000187519.7 family with sequence similarity 227, member A (from RefSeq NM_029407.1) 4933432B09Rik ENSMUST00000187519.1 ENSMUST00000187519.2 ENSMUST00000187519.3 ENSMUST00000187519.4 ENSMUST00000187519.5 ENSMUST00000187519.6 Fam227a NM_029407 Q9D3V8 Q9D3V8_MOUSE uc007wty.1 uc007wty.2 uc007wty.3 uc007wty.4 Belongs to the FAM227 family. molecular_function cellular_component biological_process uc007wty.1 uc007wty.2 uc007wty.3 uc007wty.4 
ENSMUST00000187523.2 Gm29016 ENSMUST00000187523.2 Gm29016 (from geneSymbol) ENSMUST00000187523.1 uc287ilq.1 uc287ilq.2 uc287ilq.1 uc287ilq.2 
ENSMUST00000187528.2 Gm28415 ENSMUST00000187528.2 Gm28415 (from geneSymbol) ENSMUST00000187528.1 uc287hfs.1 uc287hfs.2 uc287hfs.1 uc287hfs.2 
ENSMUST00000187530.3 Tcstv2b ENSMUST00000187530.3 2 cell stage variable group member 2B (from RefSeq NM_001310632.1) ENSMUST00000187530.1 ENSMUST00000187530.2 Gm21761 J3QK00 J3QK00_MOUSE NM_001310632 uc288qfx.1 uc288qfx.2 uc288qfx.1 uc288qfx.2 
ENSMUST00000187531.8 Wdhd1 ENSMUST00000187531.8 WD repeat and HMG-box DNA binding protein 1, transcript variant 1 (from RefSeq NM_001360532.1) A0A2K6EDP7 A0A2K6EDP7_MOUSE ENSMUST00000187531.1 ENSMUST00000187531.2 ENSMUST00000187531.3 ENSMUST00000187531.4 ENSMUST00000187531.5 ENSMUST00000187531.6 ENSMUST00000187531.7 NM_001360532 Wdhd1 uc288tdf.1 uc288tdf.2 DNA binding nucleus uc288tdf.1 uc288tdf.2 
ENSMUST00000187536.2 Gm29408 ENSMUST00000187536.2 Gm29408 (from geneSymbol) BC002127 ENSMUST00000187536.1 uc292jpj.1 uc292jpj.2 uc292jpj.1 uc292jpj.2 
ENSMUST00000187541.7 Cacna1e ENSMUST00000187541.7 calcium channel, voltage-dependent, R type, alpha 1E subunit (from RefSeq NM_009782.3) A0A087WS83 A0A087WS83_MOUSE Cacna1e ENSMUST00000187541.1 ENSMUST00000187541.2 ENSMUST00000187541.3 ENSMUST00000187541.4 ENSMUST00000187541.5 ENSMUST00000187541.6 NM_009782 uc007dav.1 uc007dav.2 uc007dav.3 This gene encodes an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes. Voltage-dependent calcium channels are multi-subunit complexes, comprised of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The isoform alpha-1E gives rise to R-type calcium currents and belongs to the high-voltage activated group. Calcium channels containing the alpha-1E subunit may be involved in the modulation of neuronal firing patterns, an important component of information processing. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC150750.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. Membrane ulti-pass membrane protein Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. ion channel activity voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel activity calcium ion binding voltage-gated calcium channel complex ion transport calcium ion transport membrane integral component of membrane voltage-gated cation channel activity regulation of ion transmembrane transport transmembrane transport calcium ion transmembrane transport uc007dav.1 uc007dav.2 uc007dav.3 
ENSMUST00000187542.8 Gm28809 ENSMUST00000187542.8 Gm28809 (from geneSymbol) ENSMUST00000187542.1 ENSMUST00000187542.2 ENSMUST00000187542.3 ENSMUST00000187542.4 ENSMUST00000187542.5 ENSMUST00000187542.6 ENSMUST00000187542.7 uc291jbe.1 uc291jbe.2 uc291jbe.3 uc291jbe.1 uc291jbe.2 uc291jbe.3 
ENSMUST00000187551.2 1700064J06Rik ENSMUST00000187551.2 RIKEN cDNA 1700064J06 gene (from RefSeq NR_045348.1) ENSMUST00000187551.1 NR_045348 uc029rjf.1 uc029rjf.2 uc029rjf.1 uc029rjf.2 
ENSMUST00000187556.2 Gm29530 ENSMUST00000187556.2 Gm29530 (from geneSymbol) AK141167 ENSMUST00000187556.1 uc288hqs.1 uc288hqs.2 uc288hqs.1 uc288hqs.2 
ENSMUST00000187560.2 Gm28240 ENSMUST00000187560.2 Gm28240 (from geneSymbol) AK089799 ENSMUST00000187560.1 uc287ifv.1 uc287ifv.2 uc287ifv.1 uc287ifv.2 
ENSMUST00000187564.2 Gm29100 ENSMUST00000187564.2 Gm29100 (from geneSymbol) BC060604 ENSMUST00000187564.1 uc287kky.1 uc287kky.2 uc287kky.1 uc287kky.2 
ENSMUST00000187571.7 Gm29027 ENSMUST00000187571.7 Gm29027 (from geneSymbol) ENSMUST00000187571.1 ENSMUST00000187571.2 ENSMUST00000187571.3 ENSMUST00000187571.4 ENSMUST00000187571.5 ENSMUST00000187571.6 uc292tcz.1 uc292tcz.2 uc292tcz.1 uc292tcz.2 
ENSMUST00000187576.7 Gm28316 ENSMUST00000187576.7 Gm28316 (from geneSymbol) ENSMUST00000187576.1 ENSMUST00000187576.2 ENSMUST00000187576.3 ENSMUST00000187576.4 ENSMUST00000187576.5 ENSMUST00000187576.6 uc292tnu.1 uc292tnu.2 uc292tnu.1 uc292tnu.2 
ENSMUST00000187580.7 Gm29511 ENSMUST00000187580.7 Gm29511 (from geneSymbol) ENSMUST00000187580.1 ENSMUST00000187580.2 ENSMUST00000187580.3 ENSMUST00000187580.4 ENSMUST00000187580.5 ENSMUST00000187580.6 uc292tmo.1 uc292tmo.2 uc292tmo.1 uc292tmo.2 
ENSMUST00000187582.7 Gm28301 ENSMUST00000187582.7 Gm28301 (from geneSymbol) ENSMUST00000187582.1 ENSMUST00000187582.2 ENSMUST00000187582.3 ENSMUST00000187582.4 ENSMUST00000187582.5 ENSMUST00000187582.6 uc292vah.1 uc292vah.2 uc292vah.1 uc292vah.2 
ENSMUST00000187587.2 Gm28585 ENSMUST00000187587.2 Gm28585 (from geneSymbol) ENSMUST00000187587.1 uc292tbz.1 uc292tbz.2 uc292tbz.1 uc292tbz.2 
ENSMUST00000187589.3 Gm29054 ENSMUST00000187589.3 Gm29054 (from geneSymbol) AK018214 ENSMUST00000187589.1 ENSMUST00000187589.2 uc009qwf.1 uc009qwf.2 uc009qwf.3 uc009qwf.4 uc009qwf.1 uc009qwf.2 uc009qwf.3 uc009qwf.4 
ENSMUST00000187597.7 Gm28733 ENSMUST00000187597.7 Gm28733 (from geneSymbol) ENSMUST00000187597.1 ENSMUST00000187597.2 ENSMUST00000187597.3 ENSMUST00000187597.4 ENSMUST00000187597.5 ENSMUST00000187597.6 uc292tph.1 uc292tph.2 uc292tph.1 uc292tph.2 
ENSMUST00000187598.2 Gm28817 ENSMUST00000187598.2 Gm28817 (from geneSymbol) ENSMUST00000187598.1 uc292uqt.1 uc292uqt.2 uc292uqt.1 uc292uqt.2 
ENSMUST00000187629.3 1810007D17Rik ENSMUST00000187629.3 RIKEN cDNA 1810007D17 gene (from RefSeq NR_038136.1) ENSMUST00000187629.1 ENSMUST00000187629.2 NR_038136 uc029ttb.1 uc029ttb.2 uc029ttb.3 uc029ttb.1 uc029ttb.2 uc029ttb.3 
ENSMUST00000187630.2 Gm28722 ENSMUST00000187630.2 Gm28722 (from geneSymbol) AK132070 ENSMUST00000187630.1 uc287khv.1 uc287khv.2 uc287khv.1 uc287khv.2 
ENSMUST00000187637.2 Gm28166 ENSMUST00000187637.2 Gm28166 (from geneSymbol) AK136678 ENSMUST00000187637.1 uc292jzp.1 uc292jzp.2 uc292jzp.1 uc292jzp.2 
ENSMUST00000187643.2 krtap20-23 ENSMUST00000187643.2 Interacts with hair keratins. (from UniProt A0A087WPH4) A0A087WPH4 A0A087WPH4_MOUSE ENSMUST00000187643.1 Gm6358 uc289fvw.1 uc289fvw.2 Interacts with hair keratins. molecular_function cellular_component biological_process uc289fvw.1 uc289fvw.2 
ENSMUST00000187645.2 Gm28475 ENSMUST00000187645.2 Gm28475 (from geneSymbol) ENSMUST00000187645.1 uc292uvb.1 uc292uvb.2 uc292uvb.1 uc292uvb.2 
ENSMUST00000187649.2 Gm28721 ENSMUST00000187649.2 Gm28721 (from geneSymbol) ENSMUST00000187649.1 uc287khs.1 uc287khs.2 uc287khs.1 uc287khs.2 
ENSMUST00000187655.2 Gm28449 ENSMUST00000187655.2 Gm28449 (from geneSymbol) ENSMUST00000187655.1 uc287ipx.1 uc287ipx.2 uc287ipx.1 uc287ipx.2 
ENSMUST00000187656.7 Gm3604 ENSMUST00000187656.7 predicted gene 3604 (from RefSeq NM_001162910.1) A0A087WPN2 A0A087WPN2_MOUSE ENSMUST00000187656.1 ENSMUST00000187656.2 ENSMUST00000187656.3 ENSMUST00000187656.4 ENSMUST00000187656.5 ENSMUST00000187656.6 Gm3604 NM_001162910 uc007qwu.1 uc007qwu.2 uc007qwu.3 uc007qwu.4 transcription regulatory region sequence-specific DNA binding nucleic acid binding cellular_component nucleus regulation of transcription, DNA-templated metal ion binding uc007qwu.1 uc007qwu.2 uc007qwu.3 uc007qwu.4 
ENSMUST00000187665.2 1810007C17Rik ENSMUST00000187665.2 RIKEN cDNA 1810007C17 gene (from RefSeq NR_045472.1) ENSMUST00000187665.1 NR_045472 uc029rsk.1 uc029rsk.2 uc029rsk.3 uc029rsk.1 uc029rsk.2 uc029rsk.3 
ENSMUST00000187667.7 Omt2b ENSMUST00000187667.7 Omt2b (from geneSymbol) D3YX29 D3YX29_MOUSE ENSMUST00000187667.1 ENSMUST00000187667.2 ENSMUST00000187667.3 ENSMUST00000187667.4 ENSMUST00000187667.5 ENSMUST00000187667.6 Omt2b S81935 uc292jae.1 uc292jae.2 molecular_function cytosol biological_process membrane integral component of membrane uc292jae.1 uc292jae.2 
ENSMUST00000187675.2 Gm28157 ENSMUST00000187675.2 Gm28157 (from geneSymbol) ENSMUST00000187675.1 uc292usd.1 uc292usd.2 uc292usd.1 uc292usd.2 
ENSMUST00000187677.2 Gm28321 ENSMUST00000187677.2 Gm28321 (from geneSymbol) AB349355 ENSMUST00000187677.1 uc287hyd.1 uc287hyd.2 uc287hyd.1 uc287hyd.2 
ENSMUST00000187685.2 Gm28865 ENSMUST00000187685.2 Gm28865 (from geneSymbol) ENSMUST00000187685.1 uc290wmg.1 uc290wmg.2 uc290wmg.1 uc290wmg.2 
ENSMUST00000187686.2 Gm28445 ENSMUST00000187686.2 Gm28445 (from geneSymbol) ENSMUST00000187686.1 uc292sbl.1 uc292sbl.2 uc292sbl.1 uc292sbl.2 
ENSMUST00000187687.2 Gm28494 ENSMUST00000187687.2 Gm28494 (from geneSymbol) ENSMUST00000187687.1 uc289zjr.1 uc289zjr.2 uc289zjr.1 uc289zjr.2 
ENSMUST00000187692.2 Gm29464 ENSMUST00000187692.2 Gm29464 (from geneSymbol) ENSMUST00000187692.1 uc290xtv.1 uc290xtv.2 uc290xtv.1 uc290xtv.2 
ENSMUST00000187697.3 Frmd8os ENSMUST00000187697.3 Frmd8os (from geneSymbol) ENSMUST00000187697.1 ENSMUST00000187697.2 GU266552 uc289qil.1 uc289qil.2 uc289qil.3 uc289qil.1 uc289qil.2 uc289qil.3 
ENSMUST00000187700.2 Gm29052 ENSMUST00000187700.2 Gm29052 (from geneSymbol) ENSMUST00000187700.1 uc289ndr.1 uc289ndr.2 uc289ndr.1 uc289ndr.2 
ENSMUST00000187705.2 ENSMUSG00000121376 ENSMUST00000187705.2 ENSMUSG00000121376 (from geneSymbol) ENSMUST00000187705.1 LF195642 uc291gjz.1 uc291gjz.2 uc291gjz.1 uc291gjz.2 
ENSMUST00000187707.2 ENSMUSG00000121683 ENSMUST00000187707.2 ENSMUSG00000121683 (from geneSymbol) ENSMUST00000187707.1 LF200206 uc011zry.1 uc011zry.2 uc011zry.3 uc011zry.1 uc011zry.2 uc011zry.3 
ENSMUST00000187709.7 Abi2 ENSMUST00000187709.7 abl interactor 2, transcript variant 17 (from RefSeq NM_001404718.1) A0A087WPP8 A0A087WPP8_MOUSE Abi2 ENSMUST00000187709.1 ENSMUST00000187709.2 ENSMUST00000187709.3 ENSMUST00000187709.4 ENSMUST00000187709.5 ENSMUST00000187709.6 NM_001404718 uc287ion.1 uc287ion.2 Cell projection, filopodium Cell projection, lamellipodium Belongs to the ABI family. actin polymerization or depolymerization uc287ion.1 uc287ion.2 
ENSMUST00000187711.2 Tent5a ENSMUST00000187711.2 terminal nucleotidyltransferase 5A, transcript variant 2 (from RefSeq NM_001160379.1) A0A087WS27 A0A087WS27_MOUSE ENSMUST00000187711.1 Fam46a NM_001160379 Tent5a uc009qwt.1 uc009qwt.2 uc009qwt.3 uc009qwt.4 Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, ChEBI:CHEBI:173115; EC=2.7.7.19; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11333; Evidence=; Belongs to the TENT family. cellular_component response to bacterium RNA adenylyltransferase activity uc009qwt.1 uc009qwt.2 uc009qwt.3 uc009qwt.4 
ENSMUST00000187712.7 Gm20838 ENSMUST00000187712.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRF5) 1700040F15Rik A0A087WRF5 A0A087WRF5_MOUSE AK077064 ENSMUST00000187712.1 ENSMUST00000187712.2 ENSMUST00000187712.3 ENSMUST00000187712.4 ENSMUST00000187712.5 ENSMUST00000187712.6 Gm20792 Gm20837 Gm20838 Gm21094 Gm21256 Gm21739 Gm21861 Gm28891 uc292szn.1 uc292szn.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc292szn.1 uc292szn.2 
ENSMUST00000187716.2 Gm28610 ENSMUST00000187716.2 Gm28610 (from geneSymbol) ENSMUST00000187716.1 uc287moe.1 uc287moe.2 uc287moe.1 uc287moe.2 
ENSMUST00000187719.2 Gm28196 ENSMUST00000187719.2 Gm28196 (from geneSymbol) ENSMUST00000187719.1 uc290aks.1 uc290aks.2 uc290aks.1 uc290aks.2 
ENSMUST00000187726.2 Gm28464 ENSMUST00000187726.2 Gm28464 (from geneSymbol) DQ874392 ENSMUST00000187726.1 uc292tac.1 uc292tac.2 uc292tac.1 uc292tac.2 
ENSMUST00000187728.7 Gm29655 ENSMUST00000187728.7 Gm29655 (from geneSymbol) DQ874391 ENSMUST00000187728.1 ENSMUST00000187728.2 ENSMUST00000187728.3 ENSMUST00000187728.4 ENSMUST00000187728.5 ENSMUST00000187728.6 uc029xxn.1 uc029xxn.2 uc029xxn.1 uc029xxn.2 
ENSMUST00000187730.2 Gm28225 ENSMUST00000187730.2 Gm28225 (from geneSymbol) ENSMUST00000187730.1 uc292utx.1 uc292utx.2 uc292utx.1 uc292utx.2 
ENSMUST00000187731.3 Gm28526 ENSMUST00000187731.3 Gm28526 (from geneSymbol) ENSMUST00000187731.1 ENSMUST00000187731.2 uc288ouf.1 uc288ouf.2 uc288ouf.1 uc288ouf.2 
ENSMUST00000187736.7 Gm29286 ENSMUST00000187736.7 Gm29286 (from geneSymbol) ENSMUST00000187736.1 ENSMUST00000187736.2 ENSMUST00000187736.3 ENSMUST00000187736.4 ENSMUST00000187736.5 ENSMUST00000187736.6 uc292thz.1 uc292thz.2 uc292thz.1 uc292thz.2 
ENSMUST00000187738.2 Gm28434 ENSMUST00000187738.2 Gm28434 (from geneSymbol) A0A087WPU2 A0A087WPU2_MOUSE BC141243 ENSMUST00000187738.1 Gm28434 uc290wwf.1 uc290wwf.2 uc290wwf.1 uc290wwf.2 
ENSMUST00000187758.7 Usp40 ENSMUST00000187758.7 ubiquitin specific peptidase 40, transcript variant 1 (from RefSeq NM_001198573.2) ENSMUST00000187758.1 ENSMUST00000187758.2 ENSMUST00000187758.3 ENSMUST00000187758.4 ENSMUST00000187758.5 ENSMUST00000187758.6 NM_001198573 Q08EB7 Q148V0 Q3TLV1 Q3TMN0 Q3V1R4 Q5EBN6 Q8BWR4 UBP40_MOUSE uc007bxy.1 uc007bxy.2 uc007bxy.3 Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BWR4-1; Sequence=Displayed; Name=2; IsoId=Q8BWR4-2; Sequence=VSP_022174; Name=3; IsoId=Q8BWR4-3; Sequence=VSP_022171; Name=4; IsoId=Q8BWR4-4; Sequence=VSP_022172, VSP_022173; Belongs to the peptidase C19 family. cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity uc007bxy.1 uc007bxy.2 uc007bxy.3 
ENSMUST00000187759.7 ENSMUSG00000121293 ENSMUST00000187759.7 ENSMUSG00000121293 (from geneSymbol) AK016790 ENSMUST00000187759.1 ENSMUST00000187759.2 ENSMUST00000187759.3 ENSMUST00000187759.4 ENSMUST00000187759.5 ENSMUST00000187759.6 uc292umo.1 uc292umo.2 uc292umo.1 uc292umo.2 
ENSMUST00000187762.2 Gm28568 ENSMUST00000187762.2 Gm28568 (from geneSymbol) ENSMUST00000187762.1 uc292thw.1 uc292thw.2 uc292thw.1 uc292thw.2 
ENSMUST00000187764.2 Gm29156 ENSMUST00000187764.2 Gm29156 (from geneSymbol) ENSMUST00000187764.1 uc287hsm.1 uc287hsm.2 uc287hsm.1 uc287hsm.2 
ENSMUST00000187768.2 Gm21627 ENSMUST00000187768.2 Belongs to the XLR/SYCP3 family. (from UniProt Q810R0) ENSMUST00000187768.1 Gm21627 Q810R0 Q810R0_MOUSE Sly uc292tyi.1 uc292tyi.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292tyi.1 uc292tyi.2 
ENSMUST00000187774.7 Dock10 ENSMUST00000187774.7 dedicator of cytokinesis 10, transcript variant 2 (from RefSeq NM_001285927.2) A0A087WQ86 DOC10_MOUSE Dock10 E9QM99 ENSMUST00000187774.1 ENSMUST00000187774.2 ENSMUST00000187774.3 ENSMUST00000187774.4 ENSMUST00000187774.5 ENSMUST00000187774.6 F1AHI9 Kiaa0694 NM_001285927 Q8BZN6 Ziz3 uc011wnz.1 uc011wnz.2 uc011wnz.3 uc011wnz.4 Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway (PubMed:25851601). Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression (PubMed:27502165). Nucleus Cytoplasm Cell projection, dendritic spine Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=DOCK10.1 ; IsoId=Q8BZN6-1; Sequence=Displayed; Name=2; IsoId=Q8BZN6-2; Sequence=VSP_007718, VSP_061616, VSP_061617; Name=3; IsoId=Q8BZN6-3; Sequence=VSP_007718, VSP_061616, VSP_061618; Name=4; Synonyms=DOCK10.2 ; IsoId=Q8BZN6-4; Sequence=VSP_058821; Expressed in brain, lung, spleen, mesenteric lymph nodes (MLN) and thymus (PubMed:15710388, PubMed:25729399). Expressed by B and T splenocytes (PubMed:21514340). In brain, expressed by Purkinje cells during postnatal development and hippocampal neurons (PubMed:25851601). At early postnatal stages, expressed broadly in the cerebellum and from P15 the expression becomes restricted to Purkinje cells. Isoform 4: Highly induced by IL4 in B splenocytes, but not T splenocytes. The DOCKER domain may mediate some GEF activity. Knockout mice are viable and fertile (PubMed:25729399, PubMed:27502165). They show decreased numbers of B- cells in spleen, both follicular B-cells and marginal zone B-cells, and in peripheral blood, but not in bone marrow (PubMed:25729399, PubMed:27502165). Their percentage of splenic CD8(+) T-cells is decreased comparing to wild types (PubMed:25729399). 'Zizim' means 'spike' in Hebrew. Belongs to the DOCK family. Sequence=ADK73961.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC28567.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; B cell homeostasis marginal zone B cell differentiation guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity nucleus nucleoplasm cytoplasm cytosol small GTPase mediated signal transduction Rho GTPase binding regulation of cell migration cell projection dendritic spine positive regulation of GTPase activity dendritic spine morphogenesis uc011wnz.1 uc011wnz.2 uc011wnz.3 uc011wnz.4 
ENSMUST00000187775.7 Gm28274 ENSMUST00000187775.7 Gm28274 (from geneSymbol) ENSMUST00000187775.1 ENSMUST00000187775.2 ENSMUST00000187775.3 ENSMUST00000187775.4 ENSMUST00000187775.5 ENSMUST00000187775.6 uc292tqm.1 uc292tqm.2 uc292tqm.1 uc292tqm.2 
ENSMUST00000187777.2 Gm28320 ENSMUST00000187777.2 Gm28320 (from geneSymbol) ENSMUST00000187777.1 uc287hyi.1 uc287hyi.2 uc287hyi.1 uc287hyi.2 
ENSMUST00000187779.2 Gm28719 ENSMUST00000187779.2 Gm28719 (from geneSymbol) ENSMUST00000187779.1 uc291gou.1 uc291gou.2 uc291gou.1 uc291gou.2 
ENSMUST00000187780.2 Gm28945 ENSMUST00000187780.2 Gm28945 (from geneSymbol) ENSMUST00000187780.1 uc292toc.1 uc292toc.2 uc292toc.1 uc292toc.2 
ENSMUST00000187783.2 Gm28641 ENSMUST00000187783.2 Gm28641 (from geneSymbol) ENSMUST00000187783.1 uc289svy.1 uc289svy.2 uc289svy.1 uc289svy.2 
ENSMUST00000187786.3 Gm28111 ENSMUST00000187786.3 Gm28111 (from geneSymbol) AK015353 ENSMUST00000187786.1 ENSMUST00000187786.2 uc292krd.1 uc292krd.2 uc292krd.3 uc292krd.1 uc292krd.2 uc292krd.3 
ENSMUST00000187794.2 Gm28395 ENSMUST00000187794.2 Gm28395 (from geneSymbol) AK039462 ENSMUST00000187794.1 uc292sbw.1 uc292sbw.2 uc292sbw.1 uc292sbw.2 
ENSMUST00000187796.3 1700121L03Rik ENSMUST00000187796.3 1700121L03Rik (from geneSymbol) AK007229 ENSMUST00000187796.1 ENSMUST00000187796.2 uc287lhz.1 uc287lhz.2 uc287lhz.3 uc287lhz.1 uc287lhz.2 uc287lhz.3 
ENSMUST00000187799.2 Gm28807 ENSMUST00000187799.2 Gm28807 (from geneSymbol) ENSMUST00000187799.1 uc291otx.1 uc291otx.2 uc291otx.1 uc291otx.2 
ENSMUST00000187800.2 Gm28851 ENSMUST00000187800.2 Gm28851 (from geneSymbol) ENSMUST00000187800.1 uc292tjh.1 uc292tjh.2 uc292tjh.1 uc292tjh.2 
ENSMUST00000187804.2 Gm28753 ENSMUST00000187804.2 Gm28753 (from geneSymbol) ENSMUST00000187804.1 uc292tlc.1 uc292tlc.2 uc292tlc.1 uc292tlc.2 
ENSMUST00000187810.2 Arl4c ENSMUST00000187810.2 Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process (By similarity). (from UniProt P61208) ARL4C_MOUSE Arl7 BC049804 ENSMUST00000187810.1 P61208 uc287kgl.1 uc287kgl.2 Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process (By similarity). Interacts with CYTH2. Interacts with alpha tubulin; interaction is independent on the ARL4C GTP or GDP binding status (By similarity). Cell projection, filopodium Cell membrane Cytoplasm Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTP binding cytoplasm cytosol plasma membrane intracellular protein transport membrane vesicle-mediated transport filopodium endocytic recycling cell projection alpha-tubulin binding uc287kgl.1 uc287kgl.2 
ENSMUST00000187814.7 Cipc ENSMUST00000187814.7 Transcriptional repressor which may act as a negative- feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK (PubMed:17310242, PubMed:19414601). However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock (PubMed:25862660). (from UniProt Q8R0W1) AK122546 CIPC_MOUSE ENSMUST00000187814.1 ENSMUST00000187814.2 ENSMUST00000187814.3 ENSMUST00000187814.4 ENSMUST00000187814.5 ENSMUST00000187814.6 Kiaa1737 Q3TUN6 Q3U423 Q3UFM0 Q80T99 Q8C680 Q8R0W1 uc288ibn.1 uc288ibn.2 Transcriptional repressor which may act as a negative- feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK (PubMed:17310242, PubMed:19414601). However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock (PubMed:25862660). Interacts with CLOCK. Forms a ternary complex with the CLOCK- BMAL1 heterodimer. Interacts with CAD and HSPA5 (By similarity). Nucleus Cytoplasm, cytosol Note=Predominantly localizes to the nucleus, where it co-localizes with CLOCK. At the G1/S boundary, partially translocated to the cytosol. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R0W1-1; Sequence=Displayed; Name=2; IsoId=Q8R0W1-2; Sequence=VSP_055396; Expressed in the heart, kidney and liver and shows a circadian oscillation in these tissues with a peak at circadian time 14 hours (at protein level). Expressed in the brain, including the suprachiasmatic nucleus (SCN) of the brain, and in multiple peripheral tissues such as heart, liver and kidney. Exhibits a circadian oscillation in the peripheral tissues with a peak at circadian time 14 hours. No visible phenotype. Knockout mice display normal locomotor activity rhythms and normal behavioral responses to light. Animals show reduction liver PER1 peak levels, but no change in the expression of other core clock genes. It is uncertain whether Met-1 or Met-36 is the initiator. Sequence=BAC65828.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding nucleus cytoplasm cytosol negative regulation of circadian rhythm negative regulation of transcription, DNA-templated rhythmic process uc288ibn.1 uc288ibn.2 
ENSMUST00000187815.2 4930579H20Rik ENSMUST00000187815.2 RIKEN cDNA 4930579H20 gene (from RefSeq NR_131034.1) ENSMUST00000187815.1 NR_131034 uc056ygk.1 uc056ygk.2 uc056ygk.1 uc056ygk.2 
ENSMUST00000187817.3 Gm28784 ENSMUST00000187817.3 Gm28784 (from geneSymbol) AK135932 ENSMUST00000187817.1 ENSMUST00000187817.2 uc007akd.1 uc007akd.2 uc007akd.3 uc007akd.4 uc007akd.1 uc007akd.2 uc007akd.3 uc007akd.4 
ENSMUST00000187820.2 Gm29449 ENSMUST00000187820.2 Gm29449 (from geneSymbol) ENSMUST00000187820.1 uc292ufa.1 uc292ufa.2 uc292ufa.1 uc292ufa.2 
ENSMUST00000187823.2 Krtap15-1 ENSMUST00000187823.2 keratin associated protein 15-1 (from RefSeq NM_013713.2) ENSMUST00000187823.1 KR151_MOUSE Krtap15 Krtap15-1 NM_013713 Pmg2 Q9QZU5 uc007zvg.1 uc007zvg.2 uc007zvg.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Expressed at high levels in skin and at lower levels in the developing mammary gland. In skin, expression starts shortly after birth and reaches a first maximum at 9 days. A second peak of expression is observed at 3.5 weeks, then levels decline and remain low in the adult. In the developing mammary gland, expression is detected exclusively at the onset of puberty. Belongs to the PMG family. molecular_function cellular_component intermediate filament biological_process uc007zvg.1 uc007zvg.2 uc007zvg.3 
ENSMUST00000187829.3 1600019K03Rik ENSMUST00000187829.3 RIKEN cDNA 1600019K03 gene (from RefSeq NR_040481.1) ENSMUST00000187829.1 ENSMUST00000187829.2 NR_040481 uc029swy.1 uc029swy.2 uc029swy.3 uc029swy.1 uc029swy.2 uc029swy.3 
ENSMUST00000187833.2 Gm28348 ENSMUST00000187833.2 Gm28348 (from geneSymbol) ENSMUST00000187833.1 uc292uvv.1 uc292uvv.2 uc292uvv.1 uc292uvv.2 
ENSMUST00000187838.2 Gm29561 ENSMUST00000187838.2 Gm29561 (from geneSymbol) ENSMUST00000187838.1 uc290ijb.1 uc290ijb.2 uc290ijb.1 uc290ijb.2 
ENSMUST00000187839.8 Ktn1 ENSMUST00000187839.8 Ktn1 (from geneSymbol) ENSMUST00000187839.1 ENSMUST00000187839.2 ENSMUST00000187839.3 ENSMUST00000187839.4 ENSMUST00000187839.5 ENSMUST00000187839.6 ENSMUST00000187839.7 F8VQC7 F8VQC7_MOUSE Ktn1 L43326 uc007tim.1 uc007tim.2 uc007tim.3 endoplasmic reticulum microtubule-based movement membrane integral component of membrane kinesin binding uc007tim.1 uc007tim.2 uc007tim.3 
ENSMUST00000187841.7 Gm28131 ENSMUST00000187841.7 Gm28131 (from geneSymbol) ENSMUST00000187841.1 ENSMUST00000187841.2 ENSMUST00000187841.3 ENSMUST00000187841.4 ENSMUST00000187841.5 ENSMUST00000187841.6 uc292svm.1 uc292svm.2 uc292svm.1 uc292svm.2 
ENSMUST00000187842.7 Rbmyf3 ENSMUST00000187842.7 RNA binding motif protein Y-linked family member 3 (from RefSeq NM_001270511.1) B2RWR6 B2RWR6_MOUSE ENSMUST00000187842.1 ENSMUST00000187842.2 ENSMUST00000187842.3 ENSMUST00000187842.4 ENSMUST00000187842.5 ENSMUST00000187842.6 NM_001270511 Rbmy1a1 Rbmyf2 Rbmyf3 uc009uzt.1 uc009uzt.2 uc009uzt.3 uc009uzt.4 Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. molecular_function nucleic acid binding RNA binding cellular_component nucleus spliceosomal complex biological_process positive regulation of mRNA splicing, via spliceosome ribonucleoprotein complex uc009uzt.1 uc009uzt.2 uc009uzt.3 uc009uzt.4 
ENSMUST00000187846.2 Gm20816 ENSMUST00000187846.2 predicted gene, 20816 (from RefSeq NM_001160144.2) ENSMUST00000187846.1 Gm20816 Gm20867 LOC382133 NM_001160144 Q5FWD4 Q5FWD4_MOUSE uc029yey.1 uc029yey.2 uc029yey.3 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc029yey.1 uc029yey.2 uc029yey.3 
ENSMUST00000187850.2 Gm43190 ENSMUST00000187850.2 Gm43190 (from geneSymbol) AK156072 ENSMUST00000187850.1 uc290hym.1 uc290hym.2 uc290hym.1 uc290hym.2 
ENSMUST00000187856.2 Gm20747 ENSMUST00000187856.2 predicted gene, 20747 (from RefSeq NM_001025241.3) ENSMUST00000187856.1 Gm20747 Gm20801 Gm20909 Gm21683 LOC434960 NM_001025241 Q5FWB5 Q5FWB5_MOUSE uc292tpu.1 uc292tpu.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292tpu.1 uc292tpu.2 
ENSMUST00000187857.2 Gm20873 ENSMUST00000187857.2 Belongs to the SPIN/STSY family. (from UniProt J3QMQ9) ENSMUST00000187857.1 Gm20873 J3QMQ9 J3QMQ9_MOUSE uc292sav.1 uc292sav.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sav.1 uc292sav.2 
ENSMUST00000187860.7 Gm28358 ENSMUST00000187860.7 Gm28358 (from geneSymbol) ENSMUST00000187860.1 ENSMUST00000187860.2 ENSMUST00000187860.3 ENSMUST00000187860.4 ENSMUST00000187860.5 ENSMUST00000187860.6 uc287lbd.1 uc287lbd.2 uc287lbd.1 uc287lbd.2 
ENSMUST00000187861.7 Nfasc ENSMUST00000187861.7 Membrane ; Single- pass type I membrane protein (from UniProt A0A087WPX3) A0A087WPX3 A0A087WPX3_MOUSE AJ543322 ENSMUST00000187861.1 ENSMUST00000187861.2 ENSMUST00000187861.3 ENSMUST00000187861.4 ENSMUST00000187861.5 ENSMUST00000187861.6 Nfasc uc287lsi.1 uc287lsi.2 Membrane ; Single- pass type I membrane protein Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. axon guidance peripheral nervous system development membrane integral component of membrane transmission of nerve impulse myelination synapse organization uc287lsi.1 uc287lsi.2 
ENSMUST00000187866.2 Gm29313 ENSMUST00000187866.2 Gm29313 (from geneSymbol) ENSMUST00000187866.1 uc292upa.1 uc292upa.2 uc292upa.1 uc292upa.2 
ENSMUST00000187867.2 Gm28989 ENSMUST00000187867.2 Gm28989 (from geneSymbol) AK135695 ENSMUST00000187867.1 uc288ptn.1 uc288ptn.2 uc288ptn.1 uc288ptn.2 
ENSMUST00000187868.3 Iqank1 ENSMUST00000187868.3 IQ motif and ankyrin repeat containing 1 (from RefSeq NM_001370920.1) A0A7D9N0L4 A0A7D9N0L4_MOUSE ENSMUST00000187868.1 ENSMUST00000187868.2 Iqank1 NM_001370920 uc288ywa.1 uc288ywa.2 uc288ywa.1 uc288ywa.2 
ENSMUST00000187873.2 E130304I02Rik ENSMUST00000187873.2 RIKEN cDNA E130304I02 gene (from RefSeq NR_033567.1) ENSMUST00000187873.1 NR_033567 uc012fio.1 uc012fio.2 uc012fio.3 uc012fio.1 uc012fio.2 uc012fio.3 
ENSMUST00000187880.2 Gm28156 ENSMUST00000187880.2 Gm28156 (from geneSymbol) ENSMUST00000187880.1 uc288ciz.1 uc288ciz.2 uc288ciz.1 uc288ciz.2 
ENSMUST00000187882.3 Gm29012 ENSMUST00000187882.3 predicted gene 29012 (from RefSeq NR_166438.1) ENSMUST00000187882.1 ENSMUST00000187882.2 NR_166438 uc287kvl.1 uc287kvl.2 uc287kvl.3 uc287kvl.1 uc287kvl.2 uc287kvl.3 
ENSMUST00000187884.2 Gm29568 ENSMUST00000187884.2 Gm29568 (from geneSymbol) ENSMUST00000187884.1 uc292uqd.1 uc292uqd.2 uc292uqd.1 uc292uqd.2 
ENSMUST00000187886.7 ENSMUSG00000121330 ENSMUST00000187886.7 ENSMUSG00000121330 (from geneSymbol) AK016790 ENSMUST00000187886.1 ENSMUST00000187886.2 ENSMUST00000187886.3 ENSMUST00000187886.4 ENSMUST00000187886.5 ENSMUST00000187886.6 uc292ucm.1 uc292ucm.2 uc292ucm.1 uc292ucm.2 
ENSMUST00000187887.2 Gm29343 ENSMUST00000187887.2 Gm29343 (from geneSymbol) ENSMUST00000187887.1 uc292txc.1 uc292txc.2 uc292txc.1 uc292txc.2 
ENSMUST00000187894.7 Gm28487 ENSMUST00000187894.7 Gm28487 (from geneSymbol) ENSMUST00000187894.1 ENSMUST00000187894.2 ENSMUST00000187894.3 ENSMUST00000187894.4 ENSMUST00000187894.5 ENSMUST00000187894.6 uc292sww.1 uc292sww.2 uc292sww.1 uc292sww.2 
ENSMUST00000187897.3 1700018L02Rik ENSMUST00000187897.3 1700018L02Rik (from geneSymbol) ENSMUST00000187897.1 ENSMUST00000187897.2 uc008hcy.1 uc008hcy.2 uc008hcy.3 uc008hcy.4 uc008hcy.5 uc008hcy.6 uc008hcy.7 uc008hcy.8 uc008hcy.1 uc008hcy.2 uc008hcy.3 uc008hcy.4 uc008hcy.5 uc008hcy.6 uc008hcy.7 uc008hcy.8 
ENSMUST00000187898.2 Gm29362 ENSMUST00000187898.2 Gm29362 (from geneSymbol) AF357386 ENSMUST00000187898.1 uc288idl.1 uc288idl.2 uc288idl.1 uc288idl.2 
ENSMUST00000187913.2 Gm28324 ENSMUST00000187913.2 Gm28324 (from geneSymbol) ENSMUST00000187913.1 uc292dow.1 uc292dow.2 uc292dow.1 uc292dow.2 
ENSMUST00000187914.2 Gm29404 ENSMUST00000187914.2 Gm29404 (from geneSymbol) ENSMUST00000187914.1 uc292ttj.1 uc292ttj.2 uc292ttj.1 uc292ttj.2 
ENSMUST00000187918.3 A530053M12Rik ENSMUST00000187918.3 A530053M12Rik (from geneSymbol) AK080055 ENSMUST00000187918.1 ENSMUST00000187918.2 uc287kxf.1 uc287kxf.2 uc287kxf.3 uc287kxf.1 uc287kxf.2 uc287kxf.3 
ENSMUST00000187920.2 2310015D24Rik ENSMUST00000187920.2 2310015D24Rik (from geneSymbol) AK136726 ENSMUST00000187920.1 uc029swe.1 uc029swe.2 uc029swe.1 uc029swe.2 
ENSMUST00000187922.3 Gm29554 ENSMUST00000187922.3 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WNW4) A0A087WNW4 A0A087WNW4_MOUSE ENSMUST00000187922.1 ENSMUST00000187922.2 Gm29554 uc292sgi.1 uc292sgi.2 uc292sgi.3 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292sgi.1 uc292sgi.2 uc292sgi.3 
ENSMUST00000187923.2 6330403L08Rik ENSMUST00000187923.2 RIKEN cDNA 6330403L08 gene (from RefSeq NR_187685.1) ENSMUST00000187923.1 NR_187685 uc291bdw.1 uc291bdw.2 uc291bdw.1 uc291bdw.2 
ENSMUST00000187926.2 Gm29629 ENSMUST00000187926.2 Gm29629 (from geneSymbol) ENSMUST00000187926.1 uc287lqz.1 uc287lqz.2 uc287lqz.1 uc287lqz.2 
ENSMUST00000187929.2 Gm28940 ENSMUST00000187929.2 Gm28940 (from geneSymbol) AK139597 ENSMUST00000187929.1 uc287jru.1 uc287jru.2 uc287jru.1 uc287jru.2 
ENSMUST00000187932.3 Gm20268 ENSMUST00000187932.3 predicted gene, 20268 (from RefSeq NR_037989.1) ENSMUST00000187932.1 ENSMUST00000187932.2 NR_037989 uc007cgb.1 uc007cgb.2 uc007cgb.3 uc007cgb.4 uc007cgb.5 uc007cgb.1 uc007cgb.2 uc007cgb.3 uc007cgb.4 uc007cgb.5 
ENSMUST00000187933.2 Gm29056 ENSMUST00000187933.2 Gm29056 (from geneSymbol) ENSMUST00000187933.1 uc292tkl.1 uc292tkl.2 uc292tkl.1 uc292tkl.2 
ENSMUST00000187941.2 Gm29358 ENSMUST00000187941.2 Gm29358 (from geneSymbol) AK165232 ENSMUST00000187941.1 uc287jec.1 uc287jec.2 uc287jec.1 uc287jec.2 
ENSMUST00000187942.2 Gm28367 ENSMUST00000187942.2 Gm28367 (from geneSymbol) ENSMUST00000187942.1 uc292uxv.1 uc292uxv.2 uc292uxv.1 uc292uxv.2 
ENSMUST00000187943.2 Gm20809 ENSMUST00000187943.2 Belongs to the SPIN/STSY family. (from UniProt Q62458) ENSMUST00000187943.1 Gm20808 Gm20809 Gm20861 Gm20863 Gm20919 Gm20927 Gm20932 Gm21076 Gm21151 Gm21155 Gm21201 Gm21344 Gm21412 Gm21427 Gm21443 Gm21462 Gm21661 Q62458 Q62458_MOUSE uc029xsu.1 uc029xsu.2 uc029xsu.3 uc029xsu.4 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc029xsu.1 uc029xsu.2 uc029xsu.3 uc029xsu.4 
ENSMUST00000187955.2 Gm29569 ENSMUST00000187955.2 Gm29569 (from geneSymbol) ENSMUST00000187955.1 uc292uqa.1 uc292uqa.2 uc292uqa.1 uc292uqa.2 
ENSMUST00000187961.3 Gm29601 ENSMUST00000187961.3 predicted gene 29601 (from RefSeq NR_188977.1) ENSMUST00000187961.1 ENSMUST00000187961.2 NR_188977 uc287kru.1 uc287kru.2 uc287kru.3 uc287kru.1 uc287kru.2 uc287kru.3 
ENSMUST00000187964.2 Gm28554 ENSMUST00000187964.2 Gm28554 (from geneSymbol) ENSMUST00000187964.1 uc292tki.1 uc292tki.2 uc292tki.1 uc292tki.2 
ENSMUST00000187978.7 Carf ENSMUST00000187978.7 calcium response factor, transcript variant 1 (from RefSeq NM_139150.5) Als2cr8 B2RRZ9 CARTF_MOUSE ENSMUST00000187978.1 ENSMUST00000187978.2 ENSMUST00000187978.3 ENSMUST00000187978.4 ENSMUST00000187978.5 ENSMUST00000187978.6 NM_139150 Q8VHI4 uc287int.1 uc287int.2 Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence (By similarity). Nucleus Highly expressed in brain and testis. The N-terminus is necessary for DNA-binding. The C-terminus is necessary for transcriptional activation. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding granular component DNA binding transcription factor activity, sequence-specific DNA binding nucleus cellular response to potassium ion positive regulation of transcription from RNA polymerase II promoter regulation of sequence-specific DNA binding transcription factor activity positive regulation of transcription from RNA polymerase II promoter in response to calcium ion cellular response to calcium ion uc287int.1 uc287int.2 
ENSMUST00000187986.3 1700049E22Rik ENSMUST00000187986.3 1700049E22Rik (from geneSymbol) AK006738 ENSMUST00000187986.1 ENSMUST00000187986.2 uc009dbx.1 uc009dbx.2 uc009dbx.3 uc009dbx.1 uc009dbx.2 uc009dbx.3 
ENSMUST00000187993.7 Gm28962 ENSMUST00000187993.7 Gm28962 (from geneSymbol) ENSMUST00000187993.1 ENSMUST00000187993.2 ENSMUST00000187993.3 ENSMUST00000187993.4 ENSMUST00000187993.5 ENSMUST00000187993.6 uc292tud.1 uc292tud.2 uc292tud.1 uc292tud.2 
ENSMUST00000187994.7 Ly6a ENSMUST00000187994.7 lymphocyte antigen 6 family member A, transcript variant 3 (from RefSeq NM_010738.3) ENSMUST00000187994.1 ENSMUST00000187994.2 ENSMUST00000187994.3 ENSMUST00000187994.4 ENSMUST00000187994.5 ENSMUST00000187994.6 LY6A_MOUSE Ly6 NM_010738 P05533 Q8BPD0 uc007wgl.1 uc007wgl.2 uc007wgl.3 uc007wgl.4 T-cell activation. P05533; Q64729: Tgfbr1; NbExp=2; IntAct=EBI-11600492, EBI-2899393; Cell membrane; Lipid-anchor, GPI-anchor. Widely expressed. O-glycosylated. Not N-glycosylated. Not phosphorylated. protein binding plasma membrane response to bacterium external side of plasma membrane membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway negative regulation of receptor activity uc007wgl.1 uc007wgl.2 uc007wgl.3 uc007wgl.4 
ENSMUST00000188005.2 Krtap28-13 ENSMUST00000188005.2 keratin associated protein 28-13 (from RefSeq NM_027778.2) A0A087WQP5 A0A087WQP5_MOUSE ENSMUST00000188005.1 Krtap28-13 NM_027778 uc057auz.1 uc057auz.2 molecular_function cellular_component biological_process uc057auz.1 uc057auz.2 
ENSMUST00000188011.2 Gm20852 ENSMUST00000188011.2 predicted gene, 20852 (from RefSeq NM_001160129.2) ENSMUST00000188011.1 Gm20852 NM_001160129 Q5M8R5 Q5M8R5_MOUSE Ssty2 uc292ucj.1 uc292ucj.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292ucj.1 uc292ucj.2 
ENSMUST00000188014.2 5031434C07Rik ENSMUST00000188014.2 5031434C07Rik (from geneSymbol) ENSMUST00000188014.1 uc291hqw.1 uc291hqw.2 uc291hqw.1 uc291hqw.2 
ENSMUST00000188026.7 Gm29074 ENSMUST00000188026.7 Gm29074 (from geneSymbol) ENSMUST00000188026.1 ENSMUST00000188026.2 ENSMUST00000188026.3 ENSMUST00000188026.4 ENSMUST00000188026.5 ENSMUST00000188026.6 uc292sza.1 uc292sza.2 uc292sza.1 uc292sza.2 
ENSMUST00000188028.7 Tnnt2 ENSMUST00000188028.7 troponin T2, cardiac, transcript variant 4 (from RefSeq NM_001130177.2) ENSMUST00000188028.1 ENSMUST00000188028.2 ENSMUST00000188028.3 ENSMUST00000188028.4 ENSMUST00000188028.5 ENSMUST00000188028.6 NM_001130177 Q6P3Z7 Q6P3Z7_MOUSE Tnnt2 uc287maq.1 uc287maq.2 Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Belongs to the troponin T family. troponin complex muscle contraction regulation of muscle contraction myofibril protein binding, bridging troponin I binding regulation of muscle filament sliding speed protein heterooligomerization actin crosslink formation cardiac muscle contraction uc287maq.1 uc287maq.2 
ENSMUST00000188031.2 Gm29539 ENSMUST00000188031.2 Gm29539 (from geneSymbol) ENSMUST00000188031.1 uc287jgu.1 uc287jgu.2 uc287jgu.1 uc287jgu.2 
ENSMUST00000188038.5 Gm33989 ENSMUST00000188038.5 Gm33989 (from geneSymbol) ENSMUST00000188038.1 ENSMUST00000188038.2 ENSMUST00000188038.3 ENSMUST00000188038.4 uc291osq.1 uc291osq.2 uc291osq.3 uc291osq.4 uc291osq.1 uc291osq.2 uc291osq.3 uc291osq.4 
ENSMUST00000188045.7 Nipsnap3a ENSMUST00000188045.7 nipsnap homolog 3A (from RefSeq NM_028529.1) ENSMUST00000188045.1 ENSMUST00000188045.2 ENSMUST00000188045.3 ENSMUST00000188045.4 ENSMUST00000188045.5 ENSMUST00000188045.6 G3X8S9 G3X8S9_MOUSE NM_028529 Nipsnap3a uc008sws.1 uc008sws.2 uc008sws.3 Belongs to the NipSnap family. molecular_function mitochondrion biological_process uc008sws.1 uc008sws.2 uc008sws.3 
ENSMUST00000188047.2 Plet1 ENSMUST00000188047.2 Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. (from UniProt Q8VEN2) AK002767 ENSMUST00000188047.1 PLET1_MOUSE Q05DM2 Q8VEN2 Q9DAT1 Q9DCI0 uc292hcp.1 uc292hcp.2 Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. Apical cell membrane ; Lipid-anchor, GPI-anchor Note=Localized at the apical membrane of the most differentiated keratinocytes of the outer root sheath (ORS), clustered mainly in planar regions of the plasma membrane at the base of microvilli. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VEN2-1; Sequence=Displayed; Name=2; IsoId=Q8VEN2-2; Sequence=VSP_031770; Present in hair follicle cells and sebaceous gland of skin, ciliated epithelial cells of trachea and bronchial tube, striated portion of submandibular gland, distal convoluted tubule cells of kidney, ciliated epithelial cells of oviduct, medulla of adrenal gland and anterior lobe of pituitary gland. Expressed in keratinocytes of the hair follicle at the trichilemmal zone corresponding to the terminally differentiated outermost suprabasal outer root sheath (ORS), including that of the sebaceous gland duct (SGD) and the directly adjacent upper distal end of the companion layer (CL). Expression is similar in all hair follicle growth stages. Also detected during both the early and late anagen phases above the bulge of stem cells. Expressed at the leading edge of the epidermal wound. Not expressed in the interfollicular epidermis (IFE), inner root sheath (IRS) and hair fiber. Highly expressed in placenta. Detected in mammary and prostate epithelia and in the pancreas (at protein level). In early embryos before gastrulation, it is specifically expressed in the distal-most part of the extraembryonic ectoderm, adjacent to the epiblast. Expression is highly restricted to the developing pharyngeal endoderm and mesonephros until day 11.5 of embryogenesis. Up-regulated during calcium-induced terminal differentiation of outer root sheath (ORS) keratinocytes. N-glycosylated. GPI-anchored. Sequence=BAB24118.1; Type=Frameshift; Evidence=; negative regulation of cell-matrix adhesion plasma membrane external side of plasma membrane membrane apical plasma membrane cell differentiation positive regulation of cell migration anchored component of membrane wound healing, spreading of epidermal cells uc292hcp.1 uc292hcp.2 
ENSMUST00000188063.2 Gm28999 ENSMUST00000188063.2 Gm28999 (from geneSymbol) ENSMUST00000188063.1 uc292sbn.1 uc292sbn.2 uc292sbn.1 uc292sbn.2 
ENSMUST00000188069.3 Gm28535 ENSMUST00000188069.3 predicted gene 28535 (from RefSeq NR_151531.1) ENSMUST00000188069.1 ENSMUST00000188069.2 NR_151531 uc287kom.1 uc287kom.2 uc287kom.3 uc287kom.1 uc287kom.2 uc287kom.3 
ENSMUST00000188071.2 Gm29270 ENSMUST00000188071.2 Gm29270 (from geneSymbol) ENSMUST00000188071.1 uc292tlu.1 uc292tlu.2 uc292tlu.1 uc292tlu.2 
ENSMUST00000188072.2 1700031L13Rik ENSMUST00000188072.2 1700031L13Rik (from geneSymbol) 1700031L13Rik A0A5F8MPQ1 A0A5F8MPQ1_MOUSE AK006583 ENSMUST00000188072.1 uc290wrq.1 uc290wrq.2 uc290wrq.1 uc290wrq.2 
ENSMUST00000188073.7 Prkag3 ENSMUST00000188073.7 protein kinase, AMP-activated, gamma 3 non-catalytic subunit (from RefSeq NM_153744.3) AAKG3_MOUSE ENSMUST00000188073.1 ENSMUST00000188073.2 ENSMUST00000188073.3 ENSMUST00000188073.4 ENSMUST00000188073.5 ENSMUST00000188073.6 NM_153744 Q0VG42 Q80WK8 Q8BGM7 Q8CJ41 uc287jgp.1 uc287jgp.2 AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism. It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=Q8BGM7-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q8BGM7-2; Sequence=VSP_015588; The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK, except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstrate sequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by the upstream activating kinase STK11/LKB1 (By similarity). The 4 CBS domains mediate binding to nucleotides. Of the 4 potential nucleotide-binding sites, 3 are occupied, designated as sites 1, 3, and 4 based on the CBS modules that provide the acidic residue for coordination with the 2'- and 3'-hydroxyl groups of the ribose of AMP. Of these, site 4 appears to be a structural site that retains a tightly held AMP molecule (AMP 3). The 2 remaining sites, 1 and 3, can bind either AMP, ADP or ATP. Site 1 (AMP, ADP or ATP 1) is the high- affinity binding site and likely accommodates AMP or ADP. Site 3 (AMP, ADP or ATP 2) is the weakest nucleotide-binding site on the gamma subunit, yet it is exquisitely sensitive to changes in nucleotide levels and this allows AMPK to respond rapidly to changes in cellular energy status. Site 3 is likely to be responsible for protection of a conserved threonine in the activation loop of the alpha catalytic subunit through conformational changes induced by binding of AMP or ADP. Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. Glycosylated; O-GlcNAcylated by OGT, promoting the AMP-activated protein kinase (AMPK) activity. Belongs to the 5'-AMP-activated protein kinase gamma subunit family. nucleotide binding AMP-activated protein kinase activity ATP binding nucleoplasm cytosol glycogen biosynthetic process glycolytic process protein phosphorylation lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process response to muscle activity involved in regulation of muscle adaptation protein kinase binding nucleotide-activated protein kinase complex adenyl ribonucleotide binding regulation of protein serine/threonine kinase activity uc287jgp.1 uc287jgp.2 
ENSMUST00000188079.2 Gm29625 ENSMUST00000188079.2 Gm29625 (from geneSymbol) ENSMUST00000188079.1 uc292tyt.1 uc292tyt.2 uc292tyt.1 uc292tyt.2 
ENSMUST00000188084.7 Gm28853 ENSMUST00000188084.7 Gm28853 (from geneSymbol) ENSMUST00000188084.1 ENSMUST00000188084.2 ENSMUST00000188084.3 ENSMUST00000188084.4 ENSMUST00000188084.5 ENSMUST00000188084.6 uc292ssj.1 uc292ssj.2 uc292ssj.1 uc292ssj.2 
ENSMUST00000188089.2 Gm29585 ENSMUST00000188089.2 Gm29585 (from geneSymbol) ENSMUST00000188089.1 uc287vue.1 uc287vue.2 uc287vue.1 uc287vue.2 
ENSMUST00000188090.7 Mdm4 ENSMUST00000188090.7 transformed mouse 3T3 cell double minute 4, transcript variant S (from RefSeq NR_126506.1) ENSMUST00000188090.1 ENSMUST00000188090.2 ENSMUST00000188090.3 ENSMUST00000188090.4 ENSMUST00000188090.5 ENSMUST00000188090.6 MDM4_MOUSE Mdmx NR_126506 O35618 Q9CYG1 uc007cpn.1 uc007cpn.2 uc007cpn.3 uc007cpn.4 This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded protein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]. Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. The short isoform is a more potent inhibitor of TP53 activity than the long isoform. Found in a trimeric complex with USP2, MDM2 and MDM4. Interacts with USP2. Interacts (phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53 (By similarity). Interacts with MDM2, TP53 and TP73. O35618; P23804-1: Mdm2; NbExp=2; IntAct=EBI-2603376, EBI-3386476; O35618; P23804-2: Mdm2; NbExp=2; IntAct=EBI-2603376, EBI-3386480; O35618; Q93009: USP7; Xeno; NbExp=4; IntAct=EBI-2603376, EBI-302474; Nucleus. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=O35618-1; Sequence=Displayed; Name=Short; Synonyms=MdmX-S; IsoId=O35618-2; Sequence=VSP_003216, VSP_003217; In all tissues tested. The short isoform is expressed in a variety of transformed cell lines. Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2. Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and degradation. Phosphorylation at Ser-341 also induces ubiquitination and degradation but to a lower extent (By similarity). Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein (By similarity). Belongs to the MDM2/MDM4 family. negative regulation of transcription from RNA polymerase II promoter regulation of heart rate heart valve development atrioventricular valve morphogenesis endocardial cushion morphogenesis ventricular septum development atrial septum development protein binding nucleus cell proliferation positive regulation of cell proliferation enzyme binding DNA damage response, signal transduction by p53 class mediator negative regulation of protein catabolic process negative regulation of apoptotic process G0 to G1 transition metal ion binding macromolecular complex assembly negative regulation of cell cycle arrest uc007cpn.1 uc007cpn.2 uc007cpn.3 uc007cpn.4 
ENSMUST00000188091.7 Rbmyf8 ENSMUST00000188091.7 RNA binding motif protein Y-linked family member 8 (from RefSeq NM_001270516.1) E9Q856 ENSMUST00000188091.1 ENSMUST00000188091.2 ENSMUST00000188091.3 ENSMUST00000188091.4 ENSMUST00000188091.5 ENSMUST00000188091.6 NM_001270516 O35698 RBY1A_MOUSE Rbm Rbmy1a1 uc029xox.1 uc029xox.2 uc029xox.3 RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. Nucleus Testis-specific. Only expressed in spermatogonia and early spermatocytes, suggesting that expression is inactivated in the XY body during meiosis. The RBMY1 proteins are encoded by repeated regions of the Y chromosome. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. Overexpression of Rbmy proteins in mice carrying the Y(d1) deletion that removes most of the multi-copy Rbmy gene cluster does not have any effect and fails to reduce the frequency of abnormal sperm. These results raize the question of the role of Rbmy proteins in sperm development. male germ cell nucleus hematopoietic progenitor cell differentiation nucleic acid binding RNA binding nucleus spliceosomal complex mRNA processing RNA splicing positive regulation of mRNA splicing, via spliceosome ribonucleoprotein complex uc029xox.1 uc029xox.2 uc029xox.3 
ENSMUST00000188096.7 Gm4767 ENSMUST00000188096.7 May be involved in transcriptional regulation. (from UniProt A0A087WNP5) A0A087WNP5 A0A087WNP5_MOUSE BC057364 ENSMUST00000188096.1 ENSMUST00000188096.2 ENSMUST00000188096.3 ENSMUST00000188096.4 ENSMUST00000188096.5 ENSMUST00000188096.6 Gm10778 Gm4767 uc007gjh.1 uc007gjh.2 May be involved in transcriptional regulation. molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc007gjh.1 uc007gjh.2 
ENSMUST00000188102.2 Gm28238 ENSMUST00000188102.2 Gm28238 (from geneSymbol) ENSMUST00000188102.1 uc292uhz.1 uc292uhz.2 uc292uhz.1 uc292uhz.2 
ENSMUST00000188108.7 Gsdmc4 ENSMUST00000188108.7 gasdermin C4 (from RefSeq NM_028992.1) E9QKJ0 ENSMUST00000188108.1 ENSMUST00000188108.2 ENSMUST00000188108.3 ENSMUST00000188108.4 ENSMUST00000188108.5 ENSMUST00000188108.6 GSDC4_MOUSE Gsdmc4 NM_028992 Q3TR54 Q9D326 uc007vzc.1 uc007vzc.2 uc007vzc.3 [Gasdermin-C4]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C4, N-terminal) binds to membranes and forms pores, triggering pyroptosis. [Gasdermin-C4, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis. Produced by the cleavage of gasdermin-D by caspase CASP8 in response to death signals. After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. [Gasdermin-C4]: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C- terminal domains mediate autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-C4, N-terminal) following cleavage by caspase CASP8. [Gasdermin-C4, N-terminal]: Homooligomer; homooligomeric ring- shaped pore complex containing 27-28 subunits when inserted in the membrane. [Gasdermin-C4]: Cytoplasm, cytosol [Gasdermin-C4, N-terminal]: Cell membrane ; Multi-pass membrane protein Intramolecular interactions between N- and C-terminal domains are important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain. Cleavage by CASP8 relieves autoinhibition by releasing the N- terminal moiety (Gasdermin-C4, N-terminal) that initiates pyroptosis. Belongs to the gasdermin family. phosphatidylserine binding molecular_function phosphatidylinositol-4,5-bisphosphate binding cellular_component cytoplasm mitochondrion microtubule organizing center cytosol plasma membrane biological_process programmed cell death membrane pyroptosis phosphatidylinositol-4-phosphate binding uc007vzc.1 uc007vzc.2 uc007vzc.3 
ENSMUST00000188113.2 Gm28410 ENSMUST00000188113.2 Gm28410 (from geneSymbol) AK087798 ENSMUST00000188113.1 uc287jod.1 uc287jod.2 uc287jod.1 uc287jod.2 
ENSMUST00000188115.2 Gm28914 ENSMUST00000188115.2 Gm28914 (from geneSymbol) ENSMUST00000188115.1 uc287lon.1 uc287lon.2 uc287lon.1 uc287lon.2 
ENSMUST00000188123.2 Gm28892 ENSMUST00000188123.2 Gm28892 (from geneSymbol) AK035023 ENSMUST00000188123.1 uc287lxu.1 uc287lxu.2 uc287lxu.1 uc287lxu.2 
ENSMUST00000188137.4 Gm28876 ENSMUST00000188137.4 Gm28876 (from geneSymbol) ENSMUST00000188137.1 ENSMUST00000188137.2 ENSMUST00000188137.3 uc289bwk.1 uc289bwk.2 uc289bwk.3 uc289bwk.4 uc289bwk.1 uc289bwk.2 uc289bwk.3 uc289bwk.4 
ENSMUST00000188149.2 Gm29636 ENSMUST00000188149.2 Gm29636 (from geneSymbol) ENSMUST00000188149.1 uc292uec.1 uc292uec.2 uc292uec.1 uc292uec.2 
ENSMUST00000188152.2 Gm28638 ENSMUST00000188152.2 Gm28638 (from geneSymbol) ENSMUST00000188152.1 uc289wni.1 uc289wni.2 uc289wni.1 uc289wni.2 
ENSMUST00000188159.7 Gm28735 ENSMUST00000188159.7 Gm28735 (from geneSymbol) ENSMUST00000188159.1 ENSMUST00000188159.2 ENSMUST00000188159.3 ENSMUST00000188159.4 ENSMUST00000188159.5 ENSMUST00000188159.6 uc292toz.1 uc292toz.2 uc292toz.1 uc292toz.2 
ENSMUST00000188160.2 Gm29417 ENSMUST00000188160.2 Gm29417 (from geneSymbol) ENSMUST00000188160.1 uc289ori.1 uc289ori.2 uc289ori.1 uc289ori.2 
ENSMUST00000188163.3 2900009J06Rik ENSMUST00000188163.3 2900009J06Rik (from geneSymbol) AK013506 ENSMUST00000188163.1 ENSMUST00000188163.2 uc007ckw.1 uc007ckw.2 uc007ckw.3 uc007ckw.4 uc007ckw.5 uc007ckw.1 uc007ckw.2 uc007ckw.3 uc007ckw.4 uc007ckw.5 
ENSMUST00000188167.2 Gm28955 ENSMUST00000188167.2 Gm28955 (from geneSymbol) ENSMUST00000188167.1 uc292sfq.1 uc292sfq.2 uc292sfq.1 uc292sfq.2 
ENSMUST00000188173.2 Gm28810 ENSMUST00000188173.2 Gm28810 (from geneSymbol) ENSMUST00000188173.1 uc292tcx.1 uc292tcx.2 uc292tcx.1 uc292tcx.2 
ENSMUST00000188175.2 Gm29695 ENSMUST00000188175.2 Gm29695 (from geneSymbol) A0A494B999 A0A494B999_MOUSE BC066109 ENSMUST00000188175.1 Gm29695 uc007coi.1 uc007coi.2 uc007coi.3 uc007coi.4 uc007coi.1 uc007coi.2 uc007coi.3 uc007coi.4 
ENSMUST00000188176.2 Gm29209 ENSMUST00000188176.2 Gm29209 (from geneSymbol) ENSMUST00000188176.1 uc292txz.1 uc292txz.2 uc292txz.1 uc292txz.2 
ENSMUST00000188180.2 Gml2 ENSMUST00000188180.2 Gml2 (from geneSymbol) A0A087WST8 A0A087WST8_MOUSE AK006826 ENSMUST00000188180.1 Gml2 Hemt1 uc288yrl.1 uc288yrl.2 molecular_function cellular_component biological_process uc288yrl.1 uc288yrl.2 
ENSMUST00000188186.2 Gm29297 ENSMUST00000188186.2 Gm29297 (from geneSymbol) ENSMUST00000188186.1 uc292uxk.1 uc292uxk.2 uc292uxk.1 uc292uxk.2 
ENSMUST00000188193.3 A730098A19Rik ENSMUST00000188193.3 RIKEN cDNA A730098A19 gene (from RefSeq NR_155422.1) ENSMUST00000188193.1 ENSMUST00000188193.2 NR_155422 uc009nyp.1 uc009nyp.2 uc009nyp.3 uc009nyp.1 uc009nyp.2 uc009nyp.3 
ENSMUST00000188196.7 Gm28280 ENSMUST00000188196.7 Gm28280 (from geneSymbol) ENSMUST00000188196.1 ENSMUST00000188196.2 ENSMUST00000188196.3 ENSMUST00000188196.4 ENSMUST00000188196.5 ENSMUST00000188196.6 uc292tib.1 uc292tib.2 uc292tib.1 uc292tib.2 
ENSMUST00000188201.2 Gm28265 ENSMUST00000188201.2 Gm28265 (from geneSymbol) ENSMUST00000188201.1 LF200543 uc289bwm.1 uc289bwm.2 uc289bwm.1 uc289bwm.2 
ENSMUST00000188202.2 Gm28984 ENSMUST00000188202.2 Gm28984 (from geneSymbol) ENSMUST00000188202.1 FJ386436 uc292sux.1 uc292sux.2 uc292sux.1 uc292sux.2 
ENSMUST00000188211.8 Larp4b ENSMUST00000188211.8 La ribonucleoprotein 4B, transcript variant 1 (from RefSeq NM_172585.3) D13Wsu64e ENSMUST00000188211.1 ENSMUST00000188211.2 ENSMUST00000188211.3 ENSMUST00000188211.4 ENSMUST00000188211.5 ENSMUST00000188211.6 ENSMUST00000188211.7 Kiaa0217 LAR4B_MOUSE Larp5 NM_172585 Q3TUH7 Q6A0A2 Q6AZA8 Q8BJP3 Q8BY17 uc007pkr.1 uc007pkr.2 uc007pkr.3 uc007pkr.4 Stimulates mRNA translation. Interacts with PABPC1. Interacts with RACK1. Associates with polysomes via the 40S ribosomal subunit. Cytoplasm, cytosol Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs in response to arsenite treatment. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6A0A2-1; Sequence=Displayed; Name=2; IsoId=Q6A0A2-2; Sequence=VSP_023987; Name=3; IsoId=Q6A0A2-3; Sequence=VSP_023988; Sequence=BAD32194.1; Type=Erroneous initiation; Evidence=; nucleic acid binding RNA binding nucleolus cytoplasm cytosol regulation of translation cytoplasmic stress granule polysomal ribosome positive regulation of translation uc007pkr.1 uc007pkr.2 uc007pkr.3 uc007pkr.4 
ENSMUST00000188215.2 Gm29591 ENSMUST00000188215.2 Gm29591 (from geneSymbol) ENSMUST00000188215.1 uc291crp.1 uc291crp.2 uc291crp.1 uc291crp.2 
ENSMUST00000188224.2 Gm29457 ENSMUST00000188224.2 Gm29457 (from geneSymbol) ENSMUST00000188224.1 uc292uag.1 uc292uag.2 uc292uag.1 uc292uag.2 
ENSMUST00000188229.2 Gm29327 ENSMUST00000188229.2 Gm29327 (from geneSymbol) ENSMUST00000188229.1 uc291rha.1 uc291rha.2 uc291rha.1 uc291rha.2 
ENSMUST00000188234.2 Gm28575 ENSMUST00000188234.2 Gm28575 (from geneSymbol) ENSMUST00000188234.1 uc292sce.1 uc292sce.2 uc292sce.1 uc292sce.2 
ENSMUST00000188242.2 Gm29324 ENSMUST00000188242.2 Gm29324 (from geneSymbol) ENSMUST00000188242.1 uc292usu.1 uc292usu.2 uc292usu.1 uc292usu.2 
ENSMUST00000188244.2 Gm57478 ENSMUST00000188244.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRF5) 1700040F15Rik A0A087WRF5 A0A087WRF5_MOUSE AK077064 ENSMUST00000188244.1 Gm20792 Gm20837 Gm20838 Gm21094 Gm21256 Gm21739 Gm21861 Gm28891 uc292twj.1 uc292twj.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc292twj.1 uc292twj.2 
ENSMUST00000188245.2 Gm29557 ENSMUST00000188245.2 Gm29557 (from geneSymbol) ENSMUST00000188245.1 uc292trj.1 uc292trj.2 uc292trj.1 uc292trj.2 
ENSMUST00000188251.7 Mx2 ENSMUST00000188251.7 MX dynamin-like GTPase 2, transcript variant 2 (from RefSeq NR_003508.1) ENSMUST00000188251.1 ENSMUST00000188251.2 ENSMUST00000188251.3 ENSMUST00000188251.4 ENSMUST00000188251.5 ENSMUST00000188251.6 NR_003508 uc289goh.1 uc289goh.2 This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to vesicular stomatitis virus, a member of the rhabdovirus family, but not to influenza virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a frameshift that inactivates this gene product. [provided by RefSeq, Jul 2008]. uc289goh.1 uc289goh.2 
ENSMUST00000188254.3 ENSMUSG00000121838 ENSMUST00000188254.3 ENSMUSG00000121838 (from geneSymbol) AK032954 ENSMUST00000188254.1 ENSMUST00000188254.2 uc287hdr.1 uc287hdr.2 uc287hdr.1 uc287hdr.2 
ENSMUST00000188255.2 Gm29190 ENSMUST00000188255.2 Gm29190 (from geneSymbol) ENSMUST00000188255.1 uc292urx.1 uc292urx.2 uc292urx.1 uc292urx.2 
ENSMUST00000188269.2 Gm21996 ENSMUST00000188269.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WSS9) A0A087WSS9 A0A087WSS9_MOUSE AK076905 ENSMUST00000188269.1 Gm21996 uc292uzx.1 uc292uzx.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292uzx.1 uc292uzx.2 
ENSMUST00000188271.4 2310068J16Rik ENSMUST00000188271.4 RIKEN cDNA 2310068J16 gene (from RefSeq NR_028124.1) ENSMUST00000188271.1 ENSMUST00000188271.2 ENSMUST00000188271.3 NR_028124 uc011zzi.1 uc011zzi.2 uc011zzi.3 uc011zzi.4 uc011zzi.1 uc011zzi.2 uc011zzi.3 uc011zzi.4 
ENSMUST00000188272.2 Gm28878 ENSMUST00000188272.2 Gm28878 (from geneSymbol) ENSMUST00000188272.1 uc292stq.1 uc292stq.2 uc292stq.1 uc292stq.2 
ENSMUST00000188273.2 Gm29515 ENSMUST00000188273.2 Gm29515 (from geneSymbol) AK043237 ENSMUST00000188273.1 uc287mjz.1 uc287mjz.2 uc287mjz.1 uc287mjz.2 
ENSMUST00000188274.2 Krtap5-1 ENSMUST00000188274.2 keratin associated protein 5-1 (from RefSeq NM_015808.2) A4IF43 ENSMUST00000188274.1 KRA51_MOUSE Krtap5-1 NM_015808 Q64507 uc009kmr.1 uc009kmr.2 uc009kmr.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q64507-1; Sequence=Displayed; Name=2 ; IsoId=Q64507-2; Sequence=VSP_052994; Expressed during the active phases of the hair cycle in the medulla and the inner root sheath of the forming hair. Also expressed in the upper layers of the epidermis of skin. Belongs to the KRTAP type 5 family. molecular_function cellular_component intermediate filament biological_process keratin filament uc009kmr.1 uc009kmr.2 uc009kmr.3 
ENSMUST00000188276.2 Gm28702 ENSMUST00000188276.2 Gm28702 (from geneSymbol) ENSMUST00000188276.1 uc292upm.1 uc292upm.2 uc292upm.1 uc292upm.2 
ENSMUST00000188293.2 Scgb2b11 ENSMUST00000188293.2 secretoglobin, family 2B, member 11 (from RefSeq NM_001310657.1) A0A087WR49 A0A087WR49_MOUSE Abpbg11 ENSMUST00000188293.1 NM_001310657 Scgb2b11 uc057bzn.1 uc057bzn.2 uc057bzn.3 Secreted Belongs to the secretoglobin family. molecular_function cellular_component extracellular space biological_process uc057bzn.1 uc057bzn.2 uc057bzn.3 
ENSMUST00000188300.2 Gm28570 ENSMUST00000188300.2 Gm28570 (from geneSymbol) ENSMUST00000188300.1 uc292scj.1 uc292scj.2 uc292scj.1 uc292scj.2 
ENSMUST00000188308.2 Gm28246 ENSMUST00000188308.2 Gm28246 (from geneSymbol) ENSMUST00000188308.1 uc292ssu.1 uc292ssu.2 uc292ssu.1 uc292ssu.2 
ENSMUST00000188309.2 Gm28625 ENSMUST00000188309.2 Gm28625 (from geneSymbol) AB033517 ENSMUST00000188309.1 uc292jgy.1 uc292jgy.2 uc292jgy.1 uc292jgy.2 
ENSMUST00000188310.2 Alppl2 ENSMUST00000188310.2 Alkaline phosphatase that can hydrolyze various phosphate compounds. (from UniProt P24823) AK145571 Akp5 Alpg Alppl2 ENSMUST00000188310.1 Eap P24823 PPBN_MOUSE Q3ULC9 uc287kbu.1 uc287kbu.2 Alkaline phosphatase that can hydrolyze various phosphate compounds. Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions. ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Inhibited by L-leucine, EDTA and heat. Homodimer. Cell membrane; Lipid-anchor, GPI-anchor. Embryo and testis. No visible phenotype (PubMed:9056646). Mice reproduce normally, give birth to live offspring and do not display any obvious phenotypic abnormalities (PubMed:9056646). In most mammals there are four different isozymes: placental (ALPP), germ cell (ALPG), intestinal (ALPI) and tissue non- specific (liver/bone/kidney) (ALPL/TNAP). Belongs to the alkaline phosphatase family. catalytic activity alkaline phosphatase activity plasma membrane membrane dephosphorylation hydrolase activity phosphatase activity myofibril anchored component of membrane metal ion binding uc287kbu.1 uc287kbu.2 
ENSMUST00000188311.7 Gm28236 ENSMUST00000188311.7 Gm28236 (from geneSymbol) ENSMUST00000188311.1 ENSMUST00000188311.2 ENSMUST00000188311.3 ENSMUST00000188311.4 ENSMUST00000188311.5 ENSMUST00000188311.6 uc292tpq.1 uc292tpq.2 uc292tpq.1 uc292tpq.2 
ENSMUST00000188313.7 Tpp2 ENSMUST00000188313.7 tripeptidyl peptidase II, transcript variant 2 (from RefSeq NM_001310540.1) ENSMUST00000188313.1 ENSMUST00000188313.2 ENSMUST00000188313.3 ENSMUST00000188313.4 ENSMUST00000188313.5 ENSMUST00000188313.6 NM_001310540 Q5D072 Q64514 TPP2_MOUSE uc007avt.1 uc007avt.2 uc007avt.3 uc007avt.4 Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin- proteasome pathway. It plays an important role in intracellular amino acid homeostasis (By similarity). Stimulates adipogenesis (PubMed:17932511). Reaction=Release of an N-terminal tripeptide from a polypeptide.; EC=3.4.14.10; Evidence=; Cytoplasm Nucleus Note=Translocates to the nucleus in response to gamma-irradiation. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q64514-1; Sequence=Displayed; Name=Short; IsoId=Q64514-2; Sequence=VSP_005446; Expressed in the brain, skeletal muscle, gonadal and mesenteric white adipose tissue and brown adipose tissues. Homozygous mutant mice die in utero before embryonic day 9.0. Heterozygous mice display normal food intake but appear lean with a significant reduction in body fat, smaller adipocytes, decreased plasma insulin levels and less white adipose tissue in the gonad, groin and mesenteric regions. The limitation of proteolytic products to tripeptides is achieved by tailoring the size of the substrate-binding cleft: the two negatively charged residues Glu-305 and Glu-331 that are blocking position P4 limit the number of residues that can be accommodated in the binding cleft and thus create a molecular ruler. At the same time, they orient substrates so that the tripeptides are removed exclusively from the N-terminus (By similarity). Belongs to the peptidase S8 family. aminopeptidase activity serine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteolysis peptidase activity serine-type peptidase activity tripeptidyl-peptidase activity nuclear body hydrolase activity peptide binding identical protein binding uc007avt.1 uc007avt.2 uc007avt.3 uc007avt.4 
ENSMUST00000188317.2 Gm20379 ENSMUST00000188317.2 Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. (from UniProt A0A087WR34) A0A087WR34 A0A087WR34_MOUSE ENSMUST00000188317.1 Gm20379 uc288pcr.1 uc288pcr.2 Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Nucleus Belongs to the HMGN family. chromatin nucleus nucleosomal DNA binding uc288pcr.1 uc288pcr.2 
ENSMUST00000188320.2 1700020M21Rik ENSMUST00000188320.2 RIKEN cDNA 1700020M21 gene (from RefSeq NR_040742.1) ENSMUST00000188320.1 NR_040742 uc029xgp.1 uc029xgp.2 uc029xgp.3 uc029xgp.1 uc029xgp.2 uc029xgp.3 
ENSMUST00000188322.7 Gm28295 ENSMUST00000188322.7 Gm28295 (from geneSymbol) DQ874392 ENSMUST00000188322.1 ENSMUST00000188322.2 ENSMUST00000188322.3 ENSMUST00000188322.4 ENSMUST00000188322.5 ENSMUST00000188322.6 uc292sxx.1 uc292sxx.2 uc292sxx.1 uc292sxx.2 
ENSMUST00000188323.2 Krtap28-10 ENSMUST00000188323.2 Krtap28-10 (from geneSymbol) A0A1Y7VP58 A0A1Y7VP58_MOUSE ENSMUST00000188323.1 Krtap28-10 uc287jtk.1 uc287jtk.2 molecular_function cellular_component biological_process uc287jtk.1 uc287jtk.2 
ENSMUST00000188324.2 2810404M03Rik ENSMUST00000188324.2 RIKEN cDNA 2810404M03 gene (from RefSeq NR_045497.1) ENSMUST00000188324.1 NR_045497 uc029wst.1 uc029wst.2 uc029wst.1 uc029wst.2 
ENSMUST00000188329.2 Gm29101 ENSMUST00000188329.2 Gm29101 (from geneSymbol) AK087269 ENSMUST00000188329.1 uc287kkz.1 uc287kkz.2 uc287kkz.1 uc287kkz.2 
ENSMUST00000188331.2 Gm28104 ENSMUST00000188331.2 Gm28104 (from geneSymbol) ENSMUST00000188331.1 uc292uyi.1 uc292uyi.2 uc292uyi.1 uc292uyi.2 
ENSMUST00000188346.7 Dnajb2 ENSMUST00000188346.7 DnaJ heat shock protein family (Hsp40) member B2, transcript variant 4 (from RefSeq NM_001159884.1) DNJB2_MOUSE Dnajb10 Dnajb2 ENSMUST00000188346.1 ENSMUST00000188346.2 ENSMUST00000188346.3 ENSMUST00000188346.4 ENSMUST00000188346.5 ENSMUST00000188346.6 NM_001159884 Q3TB24 Q8BPF6 Q921S2 Q9QYI5 uc007bom.1 uc007bom.2 uc007bom.3 uc007bom.4 Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER- associated protein degradation of misfolded proteins. Interacts with HSP70 (HSPA1A or HSPA1B). Interacts with HSPA8/Hsc70. Interacts with PSMA3 and most probably with the whole proteasomal complex. [Isoform 2]: Cytoplasm Nucleus [Isoform 1]: Endoplasmic reticulum membrane ; Lipid-anchor ; Cytoplasmic side Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9QYI5-3; Sequence=Displayed; Name=2; IsoId=Q9QYI5-1; Sequence=VSP_058709, VSP_058710; Name=3; IsoId=Q9QYI5-2; Sequence=VSP_058708, VSP_058709, VSP_058710; The J domain is sufficient to interact with HSP70 (HSPA1A or HSPA1B) and activate its ATPase activity. The J domain is also required for the HSP70-mediated and ubiquitin-dependent proteasomal degradation of proteins like ATXN3. The J domain is required to reduce PRKN cytoplasmic aggregation. The UIM domains mediate interaction with ubiquitinated chaperone clients and with the proteasome. The UIM domains may have an opposite activity to the J domain, binding ubiquitinated proteins and protecting them from HSP70-mediated proteasomal degradation. The UIM domains are not required to reduce PRKN cytoplasmic aggregation. Ubiquitinated by STUB1; does not lead to proteasomal degradation. ATPase activator activity nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol negative regulation of cell proliferation membrane inclusion body negative regulation of cell growth ER-associated ubiquitin-dependent protein catabolic process Hsp70 protein binding intrinsic component of endoplasmic reticulum membrane regulation of protein ubiquitination positive regulation of protein ubiquitination polyubiquitin binding ubiquitin protein ligase binding nuclear membrane negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of ATPase activity regulation of protein localization protein refolding ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process perinuclear region of cytoplasm unfolded protein binding chaperone binding chaperone-mediated protein folding proteasome binding negative regulation of inclusion body assembly negative regulation of protein deubiquitination regulation of chaperone-mediated protein folding proteasome complex uc007bom.1 uc007bom.2 uc007bom.3 uc007bom.4 
ENSMUST00000188347.7 Atg9a ENSMUST00000188347.7 Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:23402761, PubMed:27587839). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (By similarity). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4- kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (By similarity). In addition to autophagy, also plays a role in necrotic cell death (PubMed:27811852). (from UniProt Q68FE2) ATG9A_MOUSE Apg9l1 Atg9a BC056488 ENSMUST00000188347.1 ENSMUST00000188347.2 ENSMUST00000188347.3 ENSMUST00000188347.4 ENSMUST00000188347.5 ENSMUST00000188347.6 Q3ZAQ4 Q68FE2 uc033fjn.1 uc033fjn.2 uc033fjn.3 Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:23402761, PubMed:27587839). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (By similarity). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4- kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (By similarity). In addition to autophagy, also plays a role in necrotic cell death (PubMed:27811852). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl- sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2- diacyl-sn-glycero-3-phosphoethanolamine(out); Xref=Rhea:RHEA:38895, ChEBI:CHEBI:64612; Evidence=; Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets (By similarity). Interacts (via cytoplasmic its C-terminus) with ATG2A (By similarity). Interacts with SUPT20H (By similarity). Interacts (via the tyrosine-based sorting signal motif) with AP4M1; promoting association with the AP-4 complex (By similarity). Interacts with ARFIP1 and ARFIP2 (By similarity). Interacts with ATG4A; the interaction is direct and promotes ATG9A trafficking (By similarity). Preautophagosomal structure membrane ; Multi-pass membrane protein Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Mitochondrion membrane ; Multi-pass membrane protein Note=Mainly localizes to the trans-Golgi network (TGN) and the endosomal system; cycles between them though vesicle trafficking (PubMed:27587839). Export from the TGN to promote formation of autophagosomes is mediated by the AP-4 complex. Under amino acid starvation or rapamycin treatment, redistributes to preautophagosomal structure/phagophore assembly site (PAS). The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1. Upon autophagy induction, a portion of transiently localizes to the autophagic membranes (By similarity). Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q68FE2-1; Sequence=Displayed; Name=2; IsoId=Q68FE2-2; Sequence=VSP_061206, VSP_061207; Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer. Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of ATG9A-containing vesicles, thereby enabling growth into autophagosomes. The tyrosine-based sorting signal motif, also named YXX-psi motif, promotes interaction with the AP-4 complex. Lethality; mice die within one day after birth caused by impaired autophagy (PubMed:19926846). Mice also show aberrant activation of the innate immune response (PubMed:19926846). Fetal mice display significantly retarded growth (PubMed:26370455). Conditional deletion in brain causes axon-specific degeneration: mice were born normally, but half of them die within one week, and none live beyond 4 weeks of age (PubMed:28513333). Defects are caused by impaired autophagy in neurons, leading to progressive degeneration in the axons and their terminals, but not in neuronal cell bodies (PubMed:28513333). In addition to defects in autophagy, mice also display impaired necrotic cell death during bone morphogenesis: the bone surface is rougher and bones are more porous due to defects in necrotic cell death in bone surface formation (PubMed:27811852). Belongs to the ATG9 family. autophagosome assembly pre-autophagosomal structure mitophagy molecular_function cytoplasm endosome late endosome autophagosome Golgi apparatus trans-Golgi network autophagy synaptic vesicle protein transport membrane integral component of membrane cytoplasmic vesicle late endosome membrane negative regulation of interferon-beta production protein localization to Golgi apparatus protein localization to pre-autophagosomal structure intracellular membrane-bounded organelle late nucleophagy innate immune response recycling endosome autophagosome membrane uc033fjn.1 uc033fjn.2 uc033fjn.3 
ENSMUST00000188354.2 Gm28182 ENSMUST00000188354.2 Gm28182 (from geneSymbol) AK050417 ENSMUST00000188354.1 uc292iua.1 uc292iua.2 uc292iua.1 uc292iua.2 
ENSMUST00000188355.2 Scgb1b12 ENSMUST00000188355.2 secretoglobin, family 1B, member 12 (from RefSeq NM_001310633.1) A0A087WP21 A0A087WP21_MOUSE Abpa12 ENSMUST00000188355.1 NM_001310633 Scgb1b12 uc057bzo.1 uc057bzo.2 Secreted steroid binding extracellular region biological_process uc057bzo.1 uc057bzo.2 
ENSMUST00000188358.2 Rbmyf4 ENSMUST00000188358.2 Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. (from UniProt A0A087WPY7) A0A087WPY7 A0A087WPY7_MOUSE ENSMUST00000188358.1 Gm29289 Rbmyf4 uc292rxw.1 uc292rxw.2 Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. nucleic acid binding RNA binding nucleus spliceosomal complex positive regulation of mRNA splicing, via spliceosome ribonucleoprotein complex uc292rxw.1 uc292rxw.2 
ENSMUST00000188371.7 Terf1 ENSMUST00000188371.7 telomeric repeat binding factor 1, transcript variant 6 (from RefSeq NR_185191.1) ENSMUST00000188371.1 ENSMUST00000188371.2 ENSMUST00000188371.3 ENSMUST00000188371.4 ENSMUST00000188371.5 ENSMUST00000188371.6 NR_185191 P70371 Q9CY71 TERF1_MOUSE Trf1 uc007ajh.1 uc007ajh.2 uc007ajh.3 Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Homodimer; can contain both isoforms. Found in a complex with POT1; TINF2 and TNKS1. Interacts with ATM, TINF2, TNKS1, TNKS2, PINX1, NEK2 and MAPRE1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with RLIM (via N-terminus). Interacts with FBXO4. Interaction with TINF2 protects against interaction with FBXO4 and subsequent polyubiquitination and proteasomal degradation (By similarity). Interacts with GNL3L; this interaction promotes homodimerization. Interacts with TIN2. Interactions with GNL3L and TIN2 are mutually exclusive. Interacts with RTEL1 (By similarity). Interacts with CCDC79/TERB1. P70371; Q6ZQJ5: Dna2; NbExp=4; IntAct=EBI-6919183, EBI-6919222; P70371; Q8C0V1-1: Terb1; NbExp=4; IntAct=EBI-6919183, EBI-16089839; Nucleus Chromosome, telomere Cytoplasm, cytoskeleton, spindle Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle (By similarity). Interacts with TRIOBP isoform 1; mediates TERF1 localization to the centrosome (By similarity). The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules (By similarity). The TRFH dimerization region mediates the interaction with TINF2. The HTH domain is an independent structural unit and mediates binding to telomeric DNA. Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage. ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA. Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin- protein ligase complex, leading to its degradation by the proteasome (By similarity). telomere maintenance chromosome, telomeric region nuclear telomere cap complex nuclear chromosome, telomeric region fibrillar center DNA binding double-stranded telomeric DNA binding telomerase activity protein binding nucleus nucleoplasm chromosome nucleolus cytoplasm spindle cytoskeleton telomere maintenance via telomerase cell cycle mitotic spindle assembly checkpoint microtubule binding protein C-terminus binding negative regulation of DNA replication DNA binding, bending nuclear body positive regulation of microtubule polymerization negative regulation of telomere maintenance via telomerase telomeric DNA binding response to drug protein homodimerization activity positive regulation of apoptotic process meiotic telomere clustering positive regulation of mitotic nuclear division positive regulation of mitotic cell cycle protein heterodimerization activity protein homooligomerization cell division negative regulation of telomerase activity telomeric D-loop disassembly telosome ankyrin repeat binding G-rich strand telomeric DNA binding positive regulation of telosome assembly negative regulation of establishment of protein localization to telomere negative regulation of establishment of RNA localization to telomere negative regulation of exonuclease activity telomeric loop formation uc007ajh.1 uc007ajh.2 uc007ajh.3 
ENSMUST00000188392.2 Gm28103 ENSMUST00000188392.2 Gm28103 (from geneSymbol) ENSMUST00000188392.1 uc292uyj.1 uc292uyj.2 uc292uyj.1 uc292uyj.2 
ENSMUST00000188404.7 Gsdmc2 ENSMUST00000188404.7 gasdermin C2, transcript variant 2 (from RefSeq NM_177912.4) ENSMUST00000188404.1 ENSMUST00000188404.2 ENSMUST00000188404.3 ENSMUST00000188404.4 ENSMUST00000188404.5 ENSMUST00000188404.6 GSDC2_MOUSE Gsdmc2 NM_177912 Q2KHK6 Q2KHK8 Q8CC94 uc007vyx.1 uc007vyx.2 uc007vyx.3 [Gasdermin-C2]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C2, N-terminal) binds to membranes and forms pores, triggering pyroptosis. [Gasdermin-C2, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis in response to type-2 immunity (PubMed:34290141). Produced by the cleavage of gasdermin-D in response to type-2 immunity following worm infection (PubMed:34290141). After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids (By similarity). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis and lytic cell death in enterocytes (PubMed:34290141). [Gasdermin-C2]: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C- terminal domains mediate autoinhibition in the absence of activation signal (By similarity). The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-C2, N-terminal) following cleavage by caspase CASP8 in response to type-2 immunity following worm infection (PubMed:34290141). [Gasdermin-C2, N-terminal]: Homooligomer; homooligomeric ring- shaped pore complex containing 27-28 subunits when inserted in the membrane. [Gasdermin-C2]: Cytoplasm, cytosol [Gasdermin-C2, N-terminal]: Cell membrane ; Multi-pass membrane protein By type 2 cytokines in response to type-2 immunity following worm infection. Intramolecular interactions between N- and C-terminal domains are important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain. Cleavage by CASP8 relieves autoinhibition by releasing the N- terminal moiety (Gasdermin-C2, N-terminal) that initiates pyroptosis (PubMed:34290141). Belongs to the gasdermin family. phosphatidylserine binding molecular_function phosphatidylinositol-4,5-bisphosphate binding cellular_component cytoplasm mitochondrion microtubule organizing center cytosol plasma membrane programmed cell death membrane intestinal epithelial cell development pyroptosis phosphatidylinositol-4-phosphate binding uc007vyx.1 uc007vyx.2 uc007vyx.3 
ENSMUST00000188414.4 Slc25a13 ENSMUST00000188414.4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13, transcript variant 6 (from RefSeq NM_001410677.1) ENSMUST00000188414.1 ENSMUST00000188414.2 ENSMUST00000188414.3 NM_001410677 Q9CZF6 Q9DCF5 Q9QXX4 S2513_MOUSE Slc25a13 uc291ckb.1 uc291ckb.2 Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (By similarity). Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (By similarity). Reaction=H(+)(out) + L-aspartate(in) + L-glutamate(out) = H(+)(in) + L- aspartate(out) + L-glutamate(in); Xref=Rhea:RHEA:70783, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:29991; Evidence=; Reaction=3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) = 3- sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out); Xref=Rhea:RHEA:70967, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:61085; Evidence=; Reaction=3-sulfino-L-alanine(out) + L-aspartate(in) = 3-sulfino-L- alanine(in) + L-aspartate(out); Xref=Rhea:RHEA:70975, ChEBI:CHEBI:29991, ChEBI:CHEBI:61085; Evidence=; Homodimer (via N-terminus). Mitochondrion inner membrane ; Multi-pass membrane protein At 10.5 dpc, expressed in branchial arches, a well as in the limb and tail buds. At 13.5 dpc expression is predominant in epithelial structures and the forebrain, kidney and liver. Expression in liver is maintained into adulthood. The EF-hand 2 domain within the regulatory N-terminal domain binds one calcium in the mitochondrial intermembrane space. Calcium triggers the binding of the regulatory N-terminal domain to the C- terminal domain, opening a vestibule which allows the substrates to be translocated through the carrier domain (By similarity). In the absence of calcium, the linker loop domain may close the vestibule and prevent substrates from entering the carrier domain (By similarity). Belongs to the mitochondrial carrier (TC 2.A.29) family. L-glutamate transmembrane transporter activity calcium ion binding mitochondrion mitochondrial inner membrane ATP biosynthetic process L-aspartate transmembrane transporter activity aspartate transport L-glutamate transport membrane integral component of membrane transmembrane transporter activity identical protein binding malate-aspartate shuttle cellular respiration metal ion binding response to calcium ion transmembrane transport L-aspartate transport uc291ckb.1 uc291ckb.2 
ENSMUST00000188417.2 Gm28718 ENSMUST00000188417.2 Gm28718 (from geneSymbol) ENSMUST00000188417.1 uc292uyn.1 uc292uyn.2 uc292uyn.1 uc292uyn.2 
ENSMUST00000188421.2 Gm28091 ENSMUST00000188421.2 Gm28091 (from geneSymbol) DQ874391 ENSMUST00000188421.1 uc009vhs.1 uc009vhs.2 uc009vhs.1 uc009vhs.2 
ENSMUST00000188422.2 Gm20822 ENSMUST00000188422.2 Belongs to the SPIN/STSY family. (from UniProt J3KMI7) ENSMUST00000188422.1 Gm20822 Gm20828 J3KMI7 J3KMI7_MOUSE uc292sjk.1 uc292sjk.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sjk.1 uc292sjk.2 
ENSMUST00000188427.2 Gm28493 ENSMUST00000188427.2 Gm28493 (from geneSymbol) ENSMUST00000188427.1 uc289zju.1 uc289zju.2 uc289zju.1 uc289zju.2 
ENSMUST00000188434.7 Gm28197 ENSMUST00000188434.7 Gm28197 (from geneSymbol) ENSMUST00000188434.1 ENSMUST00000188434.2 ENSMUST00000188434.3 ENSMUST00000188434.4 ENSMUST00000188434.5 ENSMUST00000188434.6 uc292tot.1 uc292tot.2 uc292tot.1 uc292tot.2 
ENSMUST00000188435.2 2210420H20Rik ENSMUST00000188435.2 RIKEN cDNA 2210420H20 gene (from RefSeq NR_045389.1) ENSMUST00000188435.1 NR_045389 uc029tqj.1 uc029tqj.2 uc029tqj.3 uc029tqj.1 uc029tqj.2 uc029tqj.3 
ENSMUST00000188439.2 H2al1a ENSMUST00000188439.2 H2A histone family member L1A (from RefSeq NM_001111037.1) ENSMUST00000188439.1 H2AL1_MOUSE H2al1a H2al1c H2al1d H2al1f H2al1g H2al1h H2al1i NM_001111037 Q5M8Q2 uc029xib.1 uc029xib.2 Atypical histone H2A which can replace conventional H2A in some nucleosomes and may play a role during spermatogenesis. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes, replacing one or more H2A molecules. Interacts with H2BC1/TH2B; preferentially dimerizes with H2BC1/TH2B to form nucleosomes (PubMed:17261847). Nucleus Chromosome Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847). Testis-specific. Strongly enriched in step 12-16 spermatids and accumulate during late spermiogenesis, in condensing spermatids (PubMed:17261847). Remains present in mature spermatozoa isolated from epididymis (PubMed:17261847). Rapidly disappears from the paternal pericentric heterochromatin regions after sperm-egg fusion (PubMed:18703863). In contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications. Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding protein binding nucleus chromosome pericentric heterochromatin DNA packaging chromatin organization spermatogenesis cell differentiation DNA packaging complex protein heterodimerization activity uc029xib.1 uc029xib.2 
ENSMUST00000188443.2 Gm28486 ENSMUST00000188443.2 Gm28486 (from geneSymbol) DQ874391 ENSMUST00000188443.1 uc029xux.1 uc029xux.2 uc029xux.1 uc029xux.2 
ENSMUST00000188447.2 Gm28948 ENSMUST00000188447.2 Gm28948 (from geneSymbol) ENSMUST00000188447.1 uc292toi.1 uc292toi.2 uc292toi.1 uc292toi.2 
ENSMUST00000188454.7 Slco5a1 ENSMUST00000188454.7 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PVD9) AK041736 E9PVD9 E9PVD9_MOUSE ENSMUST00000188454.1 ENSMUST00000188454.2 ENSMUST00000188454.3 ENSMUST00000188454.4 ENSMUST00000188454.5 ENSMUST00000188454.6 Slco5a1 uc287gns.1 uc287gns.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the organo anion transporter (TC 2.A.60) family. Lacks conserved residue(s) required for the propagation of feature annotation. plasma membrane integral component of plasma membrane ion transport sodium-independent organic anion transmembrane transporter activity membrane integral component of membrane sodium-independent organic anion transport transmembrane transport uc287gns.1 uc287gns.2 
ENSMUST00000188457.2 Gm28252 ENSMUST00000188457.2 Gm28252 (from geneSymbol) ENSMUST00000188457.1 uc292tzm.1 uc292tzm.2 uc292tzm.1 uc292tzm.2 
ENSMUST00000188464.2 Ms4a13 ENSMUST00000188464.2 membrane-spanning 4-domains, subfamily A, member 13, transcript variant 2 (from RefSeq NM_001347435.1) ENSMUST00000188464.1 M4A13_MOUSE NM_001347435 Q5FWC3 Q717T1 uc008grv.1 uc008grv.2 uc008grv.3 May be involved in signal transduction as a component of a multimeric receptor complex. Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5FWC3-1; Sequence=Displayed; Name=2; IsoId=Q5FWC3-2; Sequence=VSP_030478; Belongs to the MS4A family. It is uncertain whether Met-1 or Met-22 is the initiator. molecular_function cellular_component biological_process membrane integral component of membrane uc008grv.1 uc008grv.2 uc008grv.3 
ENSMUST00000188465.3 1700096K18Rik ENSMUST00000188465.3 RIKEN cDNA 1700096K18 gene (from RefSeq NR_027388.1) ENSMUST00000188465.1 ENSMUST00000188465.2 NR_027388 uc012dtm.1 uc012dtm.2 uc012dtm.3 uc012dtm.4 uc012dtm.1 uc012dtm.2 uc012dtm.3 uc012dtm.4 
ENSMUST00000188473.2 Gm21529 ENSMUST00000188473.2 Gm21529 (from geneSymbol) ENSMUST00000188473.1 FJ386436 uc292swj.1 uc292swj.2 uc292swj.1 uc292swj.2 
ENSMUST00000188474.2 Platr1 ENSMUST00000188474.2 Platr1 (from geneSymbol) AK139751 ENSMUST00000188474.1 uc287lwv.1 uc287lwv.2 uc287lwv.1 uc287lwv.2 
ENSMUST00000188481.4 C030034I22Rik ENSMUST00000188481.4 C030034I22Rik (from geneSymbol) ENSMUST00000188481.1 ENSMUST00000188481.2 ENSMUST00000188481.3 LF201215 uc008dkw.1 uc008dkw.2 uc008dkw.3 uc008dkw.4 uc008dkw.5 uc008dkw.6 uc008dkw.7 uc008dkw.1 uc008dkw.2 uc008dkw.3 uc008dkw.4 uc008dkw.5 uc008dkw.6 uc008dkw.7 
ENSMUST00000188485.2 Gm29650 ENSMUST00000188485.2 Gm29650 (from geneSymbol) AK079801 ENSMUST00000188485.1 uc292rwa.1 uc292rwa.2 uc292rwa.1 uc292rwa.2 
ENSMUST00000188489.7 Zfp207 ENSMUST00000188489.7 Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome (By similarity). (from UniProt Q9JMD0) AK087885 Bugz E9PW12 ENSMUST00000188489.1 ENSMUST00000188489.2 ENSMUST00000188489.3 ENSMUST00000188489.4 ENSMUST00000188489.5 ENSMUST00000188489.6 Q99LA2 Q9JMD0 Q9Z326 ZN207_MOUSE Zep Zfp207 Znf207 uc288asr.1 uc288asr.2 Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome (By similarity). Interacts (via GLEBS region) with BUB3. Nucleus Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Note=Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9JMD0-1; Sequence=Displayed; Name=2; IsoId=Q9JMD0-2; Sequence=VSP_054255; Name=3; IsoId=Q9JMD0-3; Sequence=VSP_054257; Name=4; IsoId=Q9JMD0-4; Sequence=VSP_054256, VSP_054257; In day-13 embryo, strongly expressed in the nervous system (brain, spinal cord and dorsal root ganglia), with strong to weak expression in other regions. Continues to be strongly expressed in the neonatal brain while expression is weak in the brain and spinal cord of adult. Mainly composed of disordered low-complexity regions outside of the C2H2-type zinc fingers. Coacervation depends on hydrophobic and aromatic Phe and Tyr in the disordered low-complexity region, that may promote coacervation by forming intermolecular hydrophobic interactions. The GLEBS region mediates interaction with BUB3. The microtubule-binding region is required for efficient loading of BUB3 onto kinetochores and proper mitosis. mitotic sister chromatid segregation chromosome, centromeric region kinetochore condensed chromosome kinetochore microtubule bundle formation nucleic acid binding nucleus nucleoplasm chromosome nucleolus cytoplasm spindle cytoskeleton microtubule cell cycle chromosome segregation mitotic spindle assembly checkpoint microtubule binding heparin binding attachment of spindle microtubules to kinetochore microtubule polymerization metal ion binding protein stabilization cell division regulation of chromosome segregation mitotic spindle assembly spindle matrix uc288asr.1 uc288asr.2 
ENSMUST00000188502.2 Gm29066 ENSMUST00000188502.2 Gm29066 (from geneSymbol) ENSMUST00000188502.1 uc290tel.1 uc290tel.2 uc290tel.1 uc290tel.2 
ENSMUST00000188508.2 Gm28276 ENSMUST00000188508.2 Gm28276 (from geneSymbol) ENSMUST00000188508.1 uc292tql.1 uc292tql.2 uc292tql.1 uc292tql.2 
ENSMUST00000188509.3 Ppp2r3d ENSMUST00000188509.3 protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta, transcript variant 6 (from RefSeq NR_175917.1) A0A087WQA6 A0A087WQA6_MOUSE ENSMUST00000188509.1 ENSMUST00000188509.2 NR_175917 Ppp2r3d uc029xhb.1 uc029xhb.2 uc029xhb.3 uc029xhb.4 uc029xhb.1 uc029xhb.2 uc029xhb.3 uc029xhb.4 
ENSMUST00000188520.2 Gm29427 ENSMUST00000188520.2 Synthesis and degradation of fructose 2,6-bisphosphate. (from UniProt B2Z894) AK016729 B2Z894 B2Z894_MOUSE ENSMUST00000188520.1 Gm29427 Pfkfb2 uc287lnb.1 uc287lnb.2 Synthesis and degradation of fructose 2,6-bisphosphate. In the C-terminal section; belongs to the phosphoglycerate mutase family. catalytic activity 6-phosphofructo-2-kinase activity ATP binding fructose metabolic process fructose 2,6-bisphosphate metabolic process kinase activity phosphorylation transferase activity uc287lnb.1 uc287lnb.2 
ENSMUST00000188526.2 Gm29090 ENSMUST00000188526.2 Gm29090 (from geneSymbol) ENSMUST00000188526.1 uc292uwj.1 uc292uwj.2 uc292uwj.1 uc292uwj.2 
ENSMUST00000188530.2 Gm28820 ENSMUST00000188530.2 Gm28820 (from geneSymbol) ENSMUST00000188530.1 uc292tdr.1 uc292tdr.2 uc292tdr.1 uc292tdr.2 
ENSMUST00000188535.2 Gm29261 ENSMUST00000188535.2 Gm29261 (from geneSymbol) ENSMUST00000188535.1 uc289snq.1 uc289snq.2 uc289snq.1 uc289snq.2 
ENSMUST00000188540.2 Gm28823 ENSMUST00000188540.2 Gm28823 (from geneSymbol) ENSMUST00000188540.1 uc292uwr.1 uc292uwr.2 uc292uwr.1 uc292uwr.2 
ENSMUST00000188541.2 Gm29070 ENSMUST00000188541.2 Gm29070 (from geneSymbol) ENSMUST00000188541.1 uc292tlj.1 uc292tlj.2 uc292tlj.1 uc292tlj.2 
ENSMUST00000188544.2 Gm28178 ENSMUST00000188544.2 predicted gene 28178 (from RefSeq NR_151614.1) ENSMUST00000188544.1 NR_151614 uc287iav.1 uc287iav.2 uc287iav.1 uc287iav.2 
ENSMUST00000188547.2 Gm28448 ENSMUST00000188547.2 Gm28448 (from geneSymbol) ENSMUST00000188547.1 uc290llu.1 uc290llu.2 uc290llu.1 uc290llu.2 
ENSMUST00000188551.2 Gm29395 ENSMUST00000188551.2 Gm29395 (from geneSymbol) AK138748 ENSMUST00000188551.1 uc292jro.1 uc292jro.2 uc292jro.1 uc292jro.2 
ENSMUST00000188556.7 Gm28994 ENSMUST00000188556.7 Gm28994 (from geneSymbol) ENSMUST00000188556.1 ENSMUST00000188556.2 ENSMUST00000188556.3 ENSMUST00000188556.4 ENSMUST00000188556.5 ENSMUST00000188556.6 uc292tgj.1 uc292tgj.2 uc292tgj.1 uc292tgj.2 
ENSMUST00000188560.2 Gm28528 ENSMUST00000188560.2 Gm28528 (from geneSymbol) ENSMUST00000188560.1 uc289nhb.1 uc289nhb.2 uc289nhb.1 uc289nhb.2 
ENSMUST00000188564.7 Gm29606 ENSMUST00000188564.7 Gm29606 (from geneSymbol) ENSMUST00000188564.1 ENSMUST00000188564.2 ENSMUST00000188564.3 ENSMUST00000188564.4 ENSMUST00000188564.5 ENSMUST00000188564.6 uc292urr.1 uc292urr.2 uc292urr.1 uc292urr.2 
ENSMUST00000188565.2 Gm29080 ENSMUST00000188565.2 Gm29080 (from geneSymbol) ENSMUST00000188565.1 uc292tal.1 uc292tal.2 uc292tal.1 uc292tal.2 
ENSMUST00000188582.3 1700006F04Rik ENSMUST00000188582.3 1700006F04Rik (from geneSymbol) AK005671 ENSMUST00000188582.1 ENSMUST00000188582.2 uc029snc.1 uc029snc.2 uc029snc.3 uc029snc.4 uc029snc.1 uc029snc.2 uc029snc.3 uc029snc.4 
ENSMUST00000188585.7 Gm20896 ENSMUST00000188585.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE ENSMUST00000188585.1 ENSMUST00000188585.2 ENSMUST00000188585.3 ENSMUST00000188585.4 ENSMUST00000188585.5 ENSMUST00000188585.6 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292tca.1 uc292tca.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292tca.1 uc292tca.2 
ENSMUST00000188589.2 Gm29480 ENSMUST00000188589.2 Gm29480 (from geneSymbol) AK138204 ENSMUST00000188589.1 uc287kmv.1 uc287kmv.2 uc287kmv.1 uc287kmv.2 
ENSMUST00000188599.2 Gm29472 ENSMUST00000188599.2 Gm29472 (from geneSymbol) ENSMUST00000188599.1 uc292utp.1 uc292utp.2 uc292utp.1 uc292utp.2 
ENSMUST00000188603.2 Gm28832 ENSMUST00000188603.2 Gm28832 (from geneSymbol) ENSMUST00000188603.1 uc292uug.1 uc292uug.2 uc292uug.1 uc292uug.2 
ENSMUST00000188608.2 4930512B01Rik ENSMUST00000188608.2 RIKEN cDNA 4930512B01 gene (from RefSeq NR_033573.1) ENSMUST00000188608.1 NR_033573 uc288gxs.1 uc288gxs.2 uc288gxs.1 uc288gxs.2 
ENSMUST00000188610.2 4933400C23Rik ENSMUST00000188610.2 RIKEN cDNA 4933400C23 gene (from RefSeq NR_040770.1) ENSMUST00000188610.1 NR_040770 uc029xfm.1 uc029xfm.2 uc029xfm.1 uc029xfm.2 
ENSMUST00000188613.2 Gm28217 ENSMUST00000188613.2 Gm28217 (from geneSymbol) ENSMUST00000188613.1 uc292svv.1 uc292svv.2 uc292svv.1 uc292svv.2 
ENSMUST00000188620.7 Gm29555 ENSMUST00000188620.7 Gm29555 (from geneSymbol) ENSMUST00000188620.1 ENSMUST00000188620.2 ENSMUST00000188620.3 ENSMUST00000188620.4 ENSMUST00000188620.5 ENSMUST00000188620.6 uc292trv.1 uc292trv.2 uc292trv.1 uc292trv.2 
ENSMUST00000188623.2 Gm29019 ENSMUST00000188623.2 Gm29019 (from geneSymbol) ENSMUST00000188623.1 uc289afj.1 uc289afj.2 uc289afj.1 uc289afj.2 
ENSMUST00000188631.5 Panct2 ENSMUST00000188631.5 Panct2 (from geneSymbol) AK035520 ENSMUST00000188631.1 ENSMUST00000188631.2 ENSMUST00000188631.3 ENSMUST00000188631.4 uc287kry.1 uc287kry.2 uc287kry.1 uc287kry.2 
ENSMUST00000188637.2 Gm20918 ENSMUST00000188637.2 Belongs to the SPIN/STSY family. (from UniProt J3QN17) ENSMUST00000188637.1 Gm20918 J3QN17 J3QN17_MOUSE uc292rzk.1 uc292rzk.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292rzk.1 uc292rzk.2 
ENSMUST00000188638.2 Gm28604 ENSMUST00000188638.2 Gm28604 (from geneSymbol) ENSMUST00000188638.1 uc292tjy.1 uc292tjy.2 uc292tjy.1 uc292tjy.2 
ENSMUST00000188641.7 Eloc ENSMUST00000188641.7 elongin C, transcript variant 2 (from RefSeq NM_026456.4) ELOC_MOUSE ENSMUST00000188641.1 ENSMUST00000188641.2 ENSMUST00000188641.3 ENSMUST00000188641.4 ENSMUST00000188641.5 ENSMUST00000188641.6 Eloc NM_026456 P83940 Q63182 Tceb1 uc007ajv.1 uc007ajv.2 uc007ajv.3 uc007ajv.4 SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (PubMed:27863225, PubMed:27863226). Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. This includes the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. As part of a multisubunit ubiquitin ligase complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (By similarity). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (PubMed:33590678). Protein modification; protein ubiquitination. Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit (By similarity). The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED- EZH2 complex (PubMed:27863225, PubMed:27863226). Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either ASB2, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, SOCS1, SOCS5, ELOA, VHL or WSB1 (PubMed:10051596, PubMed:11384984, PubMed:9869640, PubMed:33590678). The elongin BC complex is part of a complex with VHL and hydroxylated HIF1A. Part of an E3 ubiquitin-protein ligase complex including ZYG11B, CUL2 and Elongin BC. Part of an E3 ubiquitin-protein ligase complex including ZER1, CUL2 and Elongin BC. Interacts with VHL. Interacts with TMF1. Interacts with SPSB1. Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component. Interacts with NOS2 in the presence of SPSB1 or SPSB2 or SPSB4 (By similarity). As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1 (By similarity). Component of the ECS(PCMTD1) complex with the substrate recognition subunit PCMTD1. Interacts with PCMTD1 (via the BC-box); the interaction is direct and stabilizes PCMTD1 (By similarity). Nucleus Ubiquitinated by the DCX(AMBRA1) complex, leading to its degradation by the proteasome. Belongs to the SKP1 family. protein binding nucleus ubiquitin-dependent protein catabolic process protein ubiquitination VCB complex positive regulation of transcription elongation from RNA polymerase II promoter macromolecular complex binding elongin complex ubiquitin-protein transferase activity uc007ajv.1 uc007ajv.2 uc007ajv.3 uc007ajv.4 
ENSMUST00000188647.7 Gm29225 ENSMUST00000188647.7 Gm29225 (from geneSymbol) ENSMUST00000188647.1 ENSMUST00000188647.2 ENSMUST00000188647.3 ENSMUST00000188647.4 ENSMUST00000188647.5 ENSMUST00000188647.6 uc292tax.1 uc292tax.2 uc292tax.1 uc292tax.2 
ENSMUST00000188651.2 Gm29648 ENSMUST00000188651.2 Gm29648 (from geneSymbol) ENSMUST00000188651.1 uc292tjk.1 uc292tjk.2 uc292tjk.1 uc292tjk.2 
ENSMUST00000188653.2 Gm29046 ENSMUST00000188653.2 Gm29046 (from geneSymbol) ENSMUST00000188653.1 uc292scr.1 uc292scr.2 uc292scr.1 uc292scr.2 
ENSMUST00000188654.2 1700001D01Rik ENSMUST00000188654.2 RIKEN cDNA 1700001D01 gene (from RefSeq NR_045475.1) ENSMUST00000188654.1 NR_045475 uc009lty.1 uc009lty.2 uc009lty.1 uc009lty.2 
ENSMUST00000188659.7 Gm29215 ENSMUST00000188659.7 Gm29215 (from geneSymbol) ENSMUST00000188659.1 ENSMUST00000188659.2 ENSMUST00000188659.3 ENSMUST00000188659.4 ENSMUST00000188659.5 ENSMUST00000188659.6 uc292tfq.1 uc292tfq.2 uc292tfq.1 uc292tfq.2 
ENSMUST00000188663.2 1700111N16Rik ENSMUST00000188663.2 RIKEN cDNA 1700111N16 gene (from RefSeq NR_033213.2) ENSMUST00000188663.1 NR_033213 uc012hjk.1 uc012hjk.2 uc012hjk.3 uc012hjk.1 uc012hjk.2 uc012hjk.3 
ENSMUST00000188667.2 Gm28545 ENSMUST00000188667.2 Gm28545 (from geneSymbol) ENSMUST00000188667.1 uc292tea.1 uc292tea.2 uc292tea.1 uc292tea.2 
ENSMUST00000188672.2 Gm20850 ENSMUST00000188672.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE BC049626 ENSMUST00000188672.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292uoj.1 uc292uoj.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292uoj.1 uc292uoj.2 
ENSMUST00000188673.7 C230029F24Rik ENSMUST00000188673.7 RIKEN cDNA C230029F24 gene (from RefSeq NR_151585.1) ENSMUST00000188673.1 ENSMUST00000188673.2 ENSMUST00000188673.3 ENSMUST00000188673.4 ENSMUST00000188673.5 ENSMUST00000188673.6 NR_151585 uc007axf.1 uc007axf.2 uc007axf.3 uc007axf.1 uc007axf.2 uc007axf.3 
ENSMUST00000188678.2 Gm28977 ENSMUST00000188678.2 Gm28977 (from geneSymbol) ENSMUST00000188678.1 uc292uzb.1 uc292uzb.2 uc292uzb.1 uc292uzb.2 
ENSMUST00000188685.7 Zfp709 ENSMUST00000188685.7 zinc finger protein 709 (from RefSeq NM_145624.4) BC021921 ENSMUST00000188685.1 ENSMUST00000188685.2 ENSMUST00000188685.3 ENSMUST00000188685.4 ENSMUST00000188685.5 ENSMUST00000188685.6 NM_145624 Q8VC29 Q8VC29_MOUSE Zfp709 uc009mex.1 uc009mex.2 uc009mex.3 uc009mex.4 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus plasma membrane regulation of transcription, DNA-templated cellular response to heat sequence-specific DNA binding metal ion binding cellular response to lipopolysaccharide uc009mex.1 uc009mex.2 uc009mex.3 uc009mex.4 
ENSMUST00000188690.2 Gm28134 ENSMUST00000188690.2 Gm28134 (from geneSymbol) ENSMUST00000188690.1 uc292uba.1 uc292uba.2 uc292uba.1 uc292uba.2 
ENSMUST00000188692.2 Gm29349 ENSMUST00000188692.2 Gm29349 (from geneSymbol) ENSMUST00000188692.1 uc292rzi.1 uc292rzi.2 uc292rzi.1 uc292rzi.2 
ENSMUST00000188694.2 Gm28152 ENSMUST00000188694.2 Gm28152 (from geneSymbol) ENSMUST00000188694.1 uc292uwk.1 uc292uwk.2 uc292uwk.1 uc292uwk.2 
ENSMUST00000188697.2 Gm29265 ENSMUST00000188697.2 Gm29265 (from geneSymbol) ENSMUST00000188697.1 uc292tzh.1 uc292tzh.2 uc292tzh.1 uc292tzh.2 
ENSMUST00000188701.7 Gm28947 ENSMUST00000188701.7 Gm28947 (from geneSymbol) ENSMUST00000188701.1 ENSMUST00000188701.2 ENSMUST00000188701.3 ENSMUST00000188701.4 ENSMUST00000188701.5 ENSMUST00000188701.6 uc292tod.1 uc292tod.2 uc292tod.1 uc292tod.2 
ENSMUST00000188706.2 Gm20917 ENSMUST00000188706.2 Belongs to the SPIN/STSY family. (from UniProt Q62457) ENSMUST00000188706.1 Gm20917 Q62457 Q62457_MOUSE uc029ygb.1 uc029ygb.2 uc029ygb.3 uc029ygb.4 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc029ygb.1 uc029ygb.2 uc029ygb.3 uc029ygb.4 
ENSMUST00000188721.2 Gm21588 ENSMUST00000188721.2 Gm21588 (from geneSymbol) ENSMUST00000188721.1 FJ386436 uc292sym.1 uc292sym.2 uc292sym.1 uc292sym.2 
ENSMUST00000188725.2 Gm29442 ENSMUST00000188725.2 Gm29442 (from geneSymbol) ENSMUST00000188725.1 uc291mbk.1 uc291mbk.2 uc291mbk.1 uc291mbk.2 
ENSMUST00000188727.2 Gm28672 ENSMUST00000188727.2 Gm28672 (from geneSymbol) ENSMUST00000188727.1 uc292uzm.1 uc292uzm.2 uc292uzm.1 uc292uzm.2 
ENSMUST00000188729.3 Gm28501 ENSMUST00000188729.3 Gm28501 (from geneSymbol) ENSMUST00000188729.1 ENSMUST00000188729.2 uc287mez.1 uc287mez.2 uc287mez.1 uc287mez.2 
ENSMUST00000188731.2 Rtl5 ENSMUST00000188731.2 retrotransposon Gag like 5 (from RefSeq NM_001278534.2) ENSMUST00000188731.1 NM_001278534 Q8C065 Q8C065_MOUSE Rgag4 Rtl5 uc292ptx.1 uc292ptx.2 uc292ptx.1 uc292ptx.2 
ENSMUST00000188737.7 Lrp8os2 ENSMUST00000188737.7 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, opposite strand 2, transcript variant 2 (from RefSeq NR_151515.1) ENSMUST00000188737.1 ENSMUST00000188737.2 ENSMUST00000188737.3 ENSMUST00000188737.4 ENSMUST00000188737.5 ENSMUST00000188737.6 NR_151515 uc008uaf.1 uc008uaf.2 uc008uaf.1 uc008uaf.2 
ENSMUST00000188743.2 Gm28403 ENSMUST00000188743.2 Gm28403 (from geneSymbol) ENSMUST00000188743.1 EU233998 uc287kvq.1 uc287kvq.2 uc287kvq.1 uc287kvq.2 
ENSMUST00000188744.2 Gm21488 ENSMUST00000188744.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WR99) A0A087WR99 A0A087WR99_MOUSE ENSMUST00000188744.1 Gm20890 Gm21488 uc292stm.1 uc292stm.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292stm.1 uc292stm.2 
ENSMUST00000188746.8 ENSMUSG00000121395 ENSMUST00000188746.8 ENSMUSG00000121395 (from geneSymbol) BC147312 ENSMUST00000188746.1 ENSMUST00000188746.2 ENSMUST00000188746.3 ENSMUST00000188746.4 ENSMUST00000188746.5 ENSMUST00000188746.6 ENSMUST00000188746.7 uc289gtk.1 uc289gtk.2 uc289gtk.3 uc289gtk.1 uc289gtk.2 uc289gtk.3 
ENSMUST00000188747.2 Gm28229 ENSMUST00000188747.2 Gm28229 (from geneSymbol) ENSMUST00000188747.1 uc292jky.1 uc292jky.2 uc292jky.1 uc292jky.2 
ENSMUST00000188753.2 Gm29157 ENSMUST00000188753.2 Gm29157 (from geneSymbol) ENSMUST00000188753.1 uc287hsk.1 uc287hsk.2 uc287hsk.1 uc287hsk.2 
ENSMUST00000188754.2 Gm20820 ENSMUST00000188754.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WPP3) A0A087WPP3 A0A087WPP3_MOUSE BC100464 ENSMUST00000188754.1 Gm20820 uc292uwu.1 uc292uwu.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292uwu.1 uc292uwu.2 
ENSMUST00000188764.2 Gm21539 ENSMUST00000188764.2 Gm21539 (from geneSymbol) ENSMUST00000188764.1 FJ386436 uc292swn.1 uc292swn.2 uc292swn.1 uc292swn.2 
ENSMUST00000188769.2 Gm28345 ENSMUST00000188769.2 Gm28345 (from geneSymbol) ENSMUST00000188769.1 uc292uwi.1 uc292uwi.2 uc292uwi.1 uc292uwi.2 
ENSMUST00000188773.2 Dalir ENSMUST00000188773.2 DNMT1 associated long intergenic non-coding RNA (from RefSeq NR_130904.1) ENSMUST00000188773.1 NR_130904 uc056ycq.1 uc056ycq.2 uc056ycq.3 uc056ycq.1 uc056ycq.2 uc056ycq.3 
ENSMUST00000188775.2 H3c10 ENSMUST00000188775.2 H3 clustered histone 10 (from RefSeq NM_178206.2) ENSMUST00000188775.1 H3.1-221 H3.1-291 H3.1-I H31_MOUSE H3a H3c1 H3c10 H3c11 H3c8 H3g H3h H3i Hist1h3a Hist1h3g Hist1h3h Hist1h3i NM_178206 P02295 P02296 P16106 P68433 Q05A97 Q3B7Z8 Q3B7Z9 Q5T009 uc007prc.1 uc007prc.2 uc007prc.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with TONSL; CHAF1A; CHAF1B; MCM2 and DNAJC9 (By similarity). P68433; P83917: Cbx1; NbExp=6; IntAct=EBI-79743, EBI-78119; P68433; Q8WTS6: SETD7; Xeno; NbExp=2; IntAct=EBI-79743, EBI-1268586; Nucleus. Chromosome. Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity). Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys- 10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. This histone is only present in mammals. Belongs to the histone H3 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly macromolecular complex protein heterodimerization activity protein heterotetramerization regulation of gene silencing uc007prc.1 uc007prc.2 uc007prc.3 
ENSMUST00000188777.7 Gm29616 ENSMUST00000188777.7 Gm29616 (from geneSymbol) ENSMUST00000188777.1 ENSMUST00000188777.2 ENSMUST00000188777.3 ENSMUST00000188777.4 ENSMUST00000188777.5 ENSMUST00000188777.6 uc292unb.1 uc292unb.2 uc292unb.1 uc292unb.2 
ENSMUST00000188778.2 Gm28754 ENSMUST00000188778.2 Gm28754 (from geneSymbol) ENSMUST00000188778.1 uc292tla.1 uc292tla.2 uc292tla.1 uc292tla.2 
ENSMUST00000188785.2 Gm28216 ENSMUST00000188785.2 Gm28216 (from geneSymbol) ENSMUST00000188785.1 FJ386436 uc292svu.1 uc292svu.2 uc292svu.1 uc292svu.2 
ENSMUST00000188788.7 Gm28518 ENSMUST00000188788.7 Gm28518 (from geneSymbol) ENSMUST00000188788.1 ENSMUST00000188788.2 ENSMUST00000188788.3 ENSMUST00000188788.4 ENSMUST00000188788.5 ENSMUST00000188788.6 uc292sze.1 uc292sze.2 uc292sze.1 uc292sze.2 
ENSMUST00000188792.7 Gm28488 ENSMUST00000188792.7 Gm28488 (from geneSymbol) ENSMUST00000188792.1 ENSMUST00000188792.2 ENSMUST00000188792.3 ENSMUST00000188792.4 ENSMUST00000188792.5 ENSMUST00000188792.6 uc292sxa.1 uc292sxa.2 uc292sxa.1 uc292sxa.2 
ENSMUST00000188801.2 B020011L13Rik ENSMUST00000188801.2 RIKEN cDNA B020011L13 gene (from RefSeq NM_001372356.1) A0A087WQI7 A0A087WQI7_MOUSE B020011L13Rik ENSMUST00000188801.1 NM_001372356 uc287lax.1 uc287lax.2 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc287lax.1 uc287lax.2 
ENSMUST00000188804.7 Mndal ENSMUST00000188804.7 myeloid nuclear differentiation antigen like, transcript variant 7 (from RefSeq NR_174475.1) D0QMC3 D0QMC4 ENSMUST00000188804.1 ENSMUST00000188804.2 ENSMUST00000188804.3 ENSMUST00000188804.4 ENSMUST00000188804.5 ENSMUST00000188804.6 MNDAL_MOUSE Mndal NR_174475 uc007drz.1 uc007drz.2 uc007drz.3 uc007drz.4 Suppresses cell growth when expressed ectopically. Nucleus Highest expression observed in spleen and thymus with moderate levels in bone marrow, lung, skin and heart, low levels in muscle, liver and intestine and little or no expression in brain and pancreas. By interferon-alpha and interferon-beta. This gene is present in strains 129/J, 129/SvJ, BALB/cAn, BALB/cJ, BALB/cHeA, CBA/N, C3H/HeJ, C3H/HeN, C57BL/6J, C57BL/10SnJ, C57L/J, NOD and NZW/LacJ but is absent in strains 129S6/SvEvTac, AKR/N, A/J, DBA/2J, NON, NZB/BlNJ, P/J, SENCARA/Pt, SWR/J and STS/A. Belongs to the HIN-200 family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding activation of innate immune response molecular_function double-stranded DNA binding nucleus nucleolus cytosol transcription factor binding response to bacterium negative regulation of cell growth positive regulation of interleukin-1 beta production cellular response to interferon-beta regulation of growth identical protein binding uc007drz.1 uc007drz.2 uc007drz.3 uc007drz.4 
ENSMUST00000188807.4 Gm21083 ENSMUST00000188807.4 predicted gene, 21083 (from RefSeq NM_001310450.2) A0A0G2JFD5 A0A0G2JFD5_MOUSE ENSMUST00000188807.1 ENSMUST00000188807.2 ENSMUST00000188807.3 Gm21083 NM_001310450 uc057btf.1 uc057btf.2 uc057btf.3 uc057btf.1 uc057btf.2 uc057btf.3 
ENSMUST00000188809.7 Gm29578 ENSMUST00000188809.7 Gm29578 (from geneSymbol) ENSMUST00000188809.1 ENSMUST00000188809.2 ENSMUST00000188809.3 ENSMUST00000188809.4 ENSMUST00000188809.5 ENSMUST00000188809.6 uc292swp.1 uc292swp.2 uc292swp.1 uc292swp.2 
ENSMUST00000188810.2 Gm28901 ENSMUST00000188810.2 Gm28901 (from geneSymbol) ENSMUST00000188810.1 uc287ksd.1 uc287ksd.2 uc287ksd.1 uc287ksd.2 
ENSMUST00000188814.2 Gm29274 ENSMUST00000188814.2 Gm29274 (from geneSymbol) ENSMUST00000188814.1 uc292thg.1 uc292thg.2 uc292thg.1 uc292thg.2 
ENSMUST00000188821.7 Gm28697 ENSMUST00000188821.7 Gm28697 (from geneSymbol) ENSMUST00000188821.1 ENSMUST00000188821.2 ENSMUST00000188821.3 ENSMUST00000188821.4 ENSMUST00000188821.5 ENSMUST00000188821.6 uc292tkg.1 uc292tkg.2 uc292tkg.1 uc292tkg.2 
ENSMUST00000188826.7 Gm28950 ENSMUST00000188826.7 Gm28950 (from geneSymbol) ENSMUST00000188826.1 ENSMUST00000188826.2 ENSMUST00000188826.3 ENSMUST00000188826.4 ENSMUST00000188826.5 ENSMUST00000188826.6 uc292toj.1 uc292toj.2 uc292toj.1 uc292toj.2 
ENSMUST00000188842.7 Syt2 ENSMUST00000188842.7 synaptotagmin II, transcript variant 1 (from RefSeq NM_009307.5) A0A0R4J2C2 A0A0R4J2C2_MOUSE ENSMUST00000188842.1 ENSMUST00000188842.2 ENSMUST00000188842.3 ENSMUST00000188842.4 ENSMUST00000188842.5 ENSMUST00000188842.6 NM_009307 Syt2 uc007csj.1 uc007csj.2 This gene encodes a member of the synaptotagmin protein family. Synaptotagmin proteins are involved in membrane trafficking and are characterized by an N-terminal transmembrane region as well as tandem calcium binding domains. The encoded protein is able to bind inositol polyphosphate and is thought to be involved in synaptic function and neurotransmitter release. [provided by RefSeq, Sep 2017]. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. ; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein Belongs to the synaptotagmin family. calcium-dependent phospholipid binding neurotransmitter secretion synaptic vesicle membrane integral component of membrane positive regulation of dendrite extension uc007csj.1 uc007csj.2 
ENSMUST00000188846.2 Gm10550 ENSMUST00000188846.2 Gm10550 (from geneSymbol) AK143968 ENSMUST00000188846.1 uc007cei.1 uc007cei.2 uc007cei.1 uc007cei.2 
ENSMUST00000188852.2 1700097N02Rik ENSMUST00000188852.2 RIKEN cDNA 1700097N02 gene (from RefSeq NR_045287.1) ENSMUST00000188852.1 NR_045287 uc008bty.1 uc008bty.2 uc008bty.3 uc008bty.1 uc008bty.2 uc008bty.3 
ENSMUST00000188864.2 Gm20894 ENSMUST00000188864.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE BC100464 ENSMUST00000188864.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292suf.1 uc292suf.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292suf.1 uc292suf.2 
ENSMUST00000188866.7 Ly6e ENSMUST00000188866.7 lymphocyte antigen 6 family member E, transcript variant 5 (from RefSeq NM_001164039.2) A0A087WNT2 A0A087WPY4 A0A087WPY4_MOUSE ENSMUST00000188866.1 ENSMUST00000188866.2 ENSMUST00000188866.3 ENSMUST00000188866.4 ENSMUST00000188866.5 ENSMUST00000188866.6 Ly6e NM_001164039 uc007wgi.1 uc007wgi.2 uc007wgi.3 uc007wgi.4 uc007wgi.1 uc007wgi.2 uc007wgi.3 uc007wgi.4 
ENSMUST00000188870.2 Gm28763 ENSMUST00000188870.2 Gm28763 (from geneSymbol) ENSMUST00000188870.1 uc292syj.1 uc292syj.2 uc292syj.1 uc292syj.2 
ENSMUST00000188874.2 Gm29229 ENSMUST00000188874.2 Gm29229 (from geneSymbol) ENSMUST00000188874.1 uc290cgq.1 uc290cgq.2 uc290cgq.1 uc290cgq.2 
ENSMUST00000188881.7 Gm21256 ENSMUST00000188881.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRF5) 1700040F15Rik A0A087WRF5 A0A087WRF5_MOUSE AK077064 ENSMUST00000188881.1 ENSMUST00000188881.2 ENSMUST00000188881.3 ENSMUST00000188881.4 ENSMUST00000188881.5 ENSMUST00000188881.6 Gm20792 Gm20837 Gm20838 Gm21094 Gm21256 Gm21739 Gm21861 Gm28891 uc292tkj.1 uc292tkj.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc292tkj.1 uc292tkj.2 
ENSMUST00000188887.2 Gm20914 ENSMUST00000188887.2 Belongs to the SPIN/STSY family. (from UniProt J3QME2) ENSMUST00000188887.1 Gm20914 J3QME2 J3QME2_MOUSE uc292sad.1 uc292sad.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sad.1 uc292sad.2 
ENSMUST00000188888.7 1700047G03Rik ENSMUST00000188888.7 1700047G03Rik (from geneSymbol) BC027576 ENSMUST00000188888.1 ENSMUST00000188888.2 ENSMUST00000188888.3 ENSMUST00000188888.4 ENSMUST00000188888.5 ENSMUST00000188888.6 uc007vhi.1 uc007vhi.2 uc007vhi.3 uc007vhi.1 uc007vhi.2 uc007vhi.3 
ENSMUST00000188893.2 Gm29162 ENSMUST00000188893.2 Gm29162 (from geneSymbol) ENSMUST00000188893.1 uc292uyo.1 uc292uyo.2 uc292uyo.1 uc292uyo.2 
ENSMUST00000188899.2 Fam24b ENSMUST00000188899.2 family with sequence similarity 24 member B (from RefSeq NM_027037.2) ENSMUST00000188899.1 FA24L_MOUSE NM_027037 Q9DAL9 uc009kbd.1 uc009kbd.2 uc009kbd.3 Secreted Belongs to the FAM24 family. molecular_function cellular_component extracellular region biological_process uc009kbd.1 uc009kbd.2 uc009kbd.3 
ENSMUST00000188904.2 Gm29146 ENSMUST00000188904.2 Gm29146 (from geneSymbol) ENSMUST00000188904.1 uc292uql.1 uc292uql.2 uc292uql.1 uc292uql.2 
ENSMUST00000188908.2 Gm21812 ENSMUST00000188908.2 Belongs to the SPIN/STSY family. (from UniProt J3QN84) ENSMUST00000188908.1 Gm21812 J3QN84 J3QN84_MOUSE uc292seb.1 uc292seb.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292seb.1 uc292seb.2 
ENSMUST00000188909.2 3830432H09Rik ENSMUST00000188909.2 RIKEN cDNA 3830432H09 gene (from RefSeq NR_126486.1) ENSMUST00000188909.1 NR_126486 uc007civ.1 uc007civ.2 uc007civ.1 uc007civ.2 
ENSMUST00000188917.7 Gm21739 ENSMUST00000188917.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRF5) 1700040F15Rik A0A087WRF5 A0A087WRF5_MOUSE ENSMUST00000188917.1 ENSMUST00000188917.2 ENSMUST00000188917.3 ENSMUST00000188917.4 ENSMUST00000188917.5 ENSMUST00000188917.6 FJ541076 Gm20792 Gm20837 Gm20838 Gm21094 Gm21256 Gm21739 Gm21861 Gm28891 uc292tii.1 uc292tii.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc292tii.1 uc292tii.2 
ENSMUST00000188922.2 Gm28571 ENSMUST00000188922.2 Gm28571 (from geneSymbol) AK039462 ENSMUST00000188922.1 uc292sci.1 uc292sci.2 uc292sci.1 uc292sci.2 
ENSMUST00000188928.3 Gm20772 ENSMUST00000188928.3 Belongs to the SPIN/STSY family. (from UniProt Q3TTD8) ENSMUST00000188928.1 ENSMUST00000188928.2 Gm20737 Gm20772 Gm20777 Gm20793 Gm20831 Gm21425 Gm21440 Q3TTD8 Q3TTD8_MOUSE uc292skk.1 uc292skk.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292skk.1 uc292skk.2 
ENSMUST00000188935.3 1700022H16Rik ENSMUST00000188935.3 RIKEN cDNA 1700022H16 gene (from RefSeq NR_045488.1) ENSMUST00000188935.1 ENSMUST00000188935.2 NR_045488 uc007nan.1 uc007nan.2 uc007nan.3 uc007nan.1 uc007nan.2 uc007nan.3 
ENSMUST00000188938.2 Gm28606 ENSMUST00000188938.2 Gm28606 (from geneSymbol) ENSMUST00000188938.1 uc292uoh.1 uc292uoh.2 uc292uoh.1 uc292uoh.2 
ENSMUST00000188946.2 Gm28944 ENSMUST00000188946.2 Gm28944 (from geneSymbol) ENSMUST00000188946.1 uc292tnz.1 uc292tnz.2 uc292tnz.1 uc292tnz.2 
ENSMUST00000188948.2 Gm28521 ENSMUST00000188948.2 Gm28521 (from geneSymbol) ENSMUST00000188948.1 uc292szr.1 uc292szr.2 uc292szr.1 uc292szr.2 
ENSMUST00000188951.2 Gm28966 ENSMUST00000188951.2 Gm28966 (from geneSymbol) ENSMUST00000188951.1 uc292tua.1 uc292tua.2 uc292tua.1 uc292tua.2 
ENSMUST00000188958.2 Gm20869 ENSMUST00000188958.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE BC049626 ENSMUST00000188958.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292ujk.1 uc292ujk.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292ujk.1 uc292ujk.2 
ENSMUST00000188962.2 Gm29112 ENSMUST00000188962.2 Gm29112 (from geneSymbol) ENSMUST00000188962.1 uc287izf.1 uc287izf.2 uc287izf.1 uc287izf.2 
ENSMUST00000188966.2 Gm28268 ENSMUST00000188966.2 Gm28268 (from geneSymbol) ENSMUST00000188966.1 uc292nmm.1 uc292nmm.2 uc292nmm.1 uc292nmm.2 
ENSMUST00000188980.2 Gm29044 ENSMUST00000188980.2 Gm29044 (from geneSymbol) ENSMUST00000188980.1 uc292sct.1 uc292sct.2 uc292sct.1 uc292sct.2 
ENSMUST00000188984.2 Gm19667 ENSMUST00000188984.2 Gm19667 (from geneSymbol) AK044276 ENSMUST00000188984.1 uc292klo.1 uc292klo.2 uc292klo.1 uc292klo.2 
ENSMUST00000188990.2 Gm28676 ENSMUST00000188990.2 Gm28676 (from geneSymbol) ENSMUST00000188990.1 uc289njg.1 uc289njg.2 uc289njg.1 uc289njg.2 
ENSMUST00000188995.2 Ms4a4a ENSMUST00000188995.2 membrane-spanning 4-domains, subfamily A, member 4A (from RefSeq NM_001310331.1) A0A087WRT7 A0A087WRT7_MOUSE ENSMUST00000188995.1 Ms4a4a NM_001310331 uc057blh.1 uc057blh.2 uc057blh.3 Belongs to the MS4A family. molecular_function cellular_component biological_process membrane integral component of membrane uc057blh.1 uc057blh.2 uc057blh.3 
ENSMUST00000188997.7 Erbin ENSMUST00000188997.7 Erbb2 interacting protein, transcript variant 4 (from RefSeq NM_001289474.1) B2RUJ2 B2RUJ2_MOUSE ENSMUST00000188997.1 ENSMUST00000188997.2 ENSMUST00000188997.3 ENSMUST00000188997.4 ENSMUST00000188997.5 ENSMUST00000188997.6 Erbb2ip Erbin NM_001289474 uc011zee.1 uc011zee.2 uc011zee.3 uc011zee.4 Belongs to the LAP (LRR and PDZ) protein family. ErbB-2 class receptor binding signal transduction negative regulation of NF-kappaB transcription factor activity uc011zee.1 uc011zee.2 uc011zee.3 uc011zee.4 
ENSMUST00000189002.2 Gm28908 ENSMUST00000189002.2 Gm28908 (from geneSymbol) ENSMUST00000189002.1 uc292tqf.1 uc292tqf.2 uc292tqf.1 uc292tqf.2 
ENSMUST00000189007.2 Gm28576 ENSMUST00000189007.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRP6) A0A087WRP6 A0A087WRP6_MOUSE ENSMUST00000189007.1 Gm28576 Gm28998 uc292scd.1 uc292scd.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292scd.1 uc292scd.2 
ENSMUST00000189008.3 2310034G01Rik ENSMUST00000189008.3 2310034G01Rik (from geneSymbol) 2310034G01Rik A0A286YDL3 A0A286YDL3_MOUSE ENSMUST00000189008.1 ENSMUST00000189008.2 uc029tsp.1 uc029tsp.2 uc029tsp.3 uc029tsp.1 uc029tsp.2 uc029tsp.3 
ENSMUST00000189014.2 Gm28743 ENSMUST00000189014.2 Gm28743 (from geneSymbol) ENSMUST00000189014.1 uc292ute.1 uc292ute.2 uc292ute.1 uc292ute.2 
ENSMUST00000189021.2 Gm28346 ENSMUST00000189021.2 Gm28346 (from geneSymbol) ENSMUST00000189021.1 uc292uwh.1 uc292uwh.2 uc292uwh.1 uc292uwh.2 
ENSMUST00000189022.8 Drgx ENSMUST00000189022.8 dorsal root ganglia homeobox, transcript variant 1 (from RefSeq NM_001347590.1) A2RTS1 B2ZIF3 B2ZIF4 DRGX_MOUSE Drg11 ENSMUST00000189022.1 ENSMUST00000189022.2 ENSMUST00000189022.3 ENSMUST00000189022.4 ENSMUST00000189022.5 ENSMUST00000189022.6 ENSMUST00000189022.7 NM_001347590 Prrxl1 Q8BYH0 Q8K3F8 uc011zin.1 uc011zin.2 uc011zin.3 uc011zin.4 Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain. Interacts with RGMB. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BYH0-1; Sequence=Displayed; Name=2; Synonyms=Prrxl1-B; IsoId=Q8BYH0-2; Sequence=VSP_040392; Expressed in the dorsal horn of the spinal cord and dorsal root ganglia. Isoform 1 is higher expressed than isoform 2 both in the dorsal root ganglia and in the spinal cord. Isoform 2 is exclusively localized in neurons primarily involved in the processing of the pain somatosensory modality. First detected at 12.5 dpc in newly generated neurons adjacent to the ventricular zone of the dorsal spinal cord. Later expressed in lateral region of the dorsal spinal cord and dorsal root ganglia at 13.5 dpc with increased levels at 15.5 dpc. Defects in the projection pattern of nociceptive sensory neurons to the dorsal horn of the developing spinal cord leading to reduced sensitivity to painful stimuli. They die within 3 weeks of birth. Mice lacking Drgx exhibit reduced expression of Rgmb in dorsal root ganglion sensory neurons. Belongs to the paired homeobox family. RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding neuron migration DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development nervous system development axonogenesis axon guidance detection of chemical stimulus detection of temperature stimulus dorsal spinal cord development trigeminal nerve development neuron differentiation sequence-specific DNA binding sensory perception of mechanical stimulus uc011zin.1 uc011zin.2 uc011zin.3 uc011zin.4 
ENSMUST00000189032.7 Cimap2 ENSMUST00000189032.7 ciliary microtubule associated protein 2, transcript variant 4 (from RefSeq NR_189598.1) A2AVQ4 A2AVQ5 CMAP2_MOUSE ENSMUST00000189032.1 ENSMUST00000189032.2 ENSMUST00000189032.3 ENSMUST00000189032.4 ENSMUST00000189032.5 ENSMUST00000189032.6 Lem Lexm NR_189598 Q7TPM4 uc290ogi.1 uc290ogi.2 Was reported to promote CD8+ T cell immunity through effects on mitochondrial respiration (PubMed:25883318). However, the corresponding article has been retracted (PubMed:27980177). Sequence=AAH55111.1; Type=Erroneous initiation; Evidence=; uc290ogi.1 uc290ogi.2 
ENSMUST00000189033.3 Gm28258 ENSMUST00000189033.3 Gm28258 (from geneSymbol) ENSMUST00000189033.1 ENSMUST00000189033.2 uc291rhj.1 uc291rhj.2 uc291rhj.3 uc291rhj.1 uc291rhj.2 uc291rhj.3 
ENSMUST00000189035.2 B530045E10Rik ENSMUST00000189035.2 uncharacterized LOC118567817 (from RefSeq NR_190049.1) ENSMUST00000189035.1 NR_190049 uc007gxm.1 uc007gxm.2 uc007gxm.1 uc007gxm.2 
ENSMUST00000189036.3 1700029E06Rik ENSMUST00000189036.3 1700029E06Rik (from geneSymbol) AK006485 ENSMUST00000189036.1 ENSMUST00000189036.2 uc008xlw.1 uc008xlw.2 uc008xlw.3 uc008xlw.1 uc008xlw.2 uc008xlw.3 
ENSMUST00000189046.3 1700036G14Rik ENSMUST00000189046.3 1700036G14Rik (from geneSymbol) AK006614 ENSMUST00000189046.1 ENSMUST00000189046.2 uc008pqo.1 uc008pqo.2 uc008pqo.3 uc008pqo.4 uc008pqo.1 uc008pqo.2 uc008pqo.3 uc008pqo.4 
ENSMUST00000189053.2 Gm29329 ENSMUST00000189053.2 Gm29329 (from geneSymbol) ENSMUST00000189053.1 uc292sea.1 uc292sea.2 uc292sea.1 uc292sea.2 
ENSMUST00000189054.2 Gm29436 ENSMUST00000189054.2 Gm29436 (from geneSymbol) ENSMUST00000189054.1 uc292uyx.1 uc292uyx.2 uc292uyx.1 uc292uyx.2 
ENSMUST00000189056.2 4930533P14Rik ENSMUST00000189056.2 RIKEN cDNA 4930533P14 gene (from RefSeq NR_040478.1) ENSMUST00000189056.1 NR_040478 uc029qsi.1 uc029qsi.2 uc029qsi.1 uc029qsi.2 
ENSMUST00000189058.7 Gm28850 ENSMUST00000189058.7 Gm28850 (from geneSymbol) ENSMUST00000189058.1 ENSMUST00000189058.2 ENSMUST00000189058.3 ENSMUST00000189058.4 ENSMUST00000189058.5 ENSMUST00000189058.6 uc292tfu.1 uc292tfu.2 uc292tfu.1 uc292tfu.2 
ENSMUST00000189061.7 Rgs1 ENSMUST00000189061.7 regulator of G-protein signaling 1 (from RefSeq NM_015811.2) ENSMUST00000189061.1 ENSMUST00000189061.2 ENSMUST00000189061.3 ENSMUST00000189061.4 ENSMUST00000189061.5 ENSMUST00000189061.6 NM_015811 Q3TBD1 Q3TC18 Q3TD56 Q3U477 Q9JL25 RGS1_MOUSE uc007cxj.1 uc007cxj.2 uc007cxj.3 uc007cxj.4 Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (PubMed:10779778). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (By similarity). Interacts with GNAI1 and GNAQ. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JL25-1; Sequence=Displayed; Name=2; IsoId=Q9JL25-2; Sequence=VSP_036732; Detected in spleen, lymph node and intestine. Sequence=AAF34624.1; Type=Erroneous initiation; Evidence=; Sequence=AAH28634.1; Type=Erroneous initiation; Evidence=; Sequence=BAE23749.1; Type=Erroneous initiation; Evidence=; Sequence=BAE32557.1; Type=Erroneous initiation; Evidence=; Sequence=BAE41748.1; Type=Erroneous initiation; Evidence=; Sequence=BAE42139.1; Type=Erroneous initiation; Evidence=; G-protein alpha-subunit binding GTPase activator activity cytoplasm cytosol plasma membrane signal transduction G-protein coupled receptor signaling pathway regulation of G-protein coupled receptor protein signaling pathway response to bacterium negative regulation of signal transduction membrane extrinsic component of cytoplasmic side of plasma membrane positive regulation of GTPase activity leukotriene signaling pathway uc007cxj.1 uc007cxj.2 uc007cxj.3 uc007cxj.4 
ENSMUST00000189073.2 Gm21719 ENSMUST00000189073.2 Belongs to the SPIN/STSY family. (from UniProt J3KMI9) ENSMUST00000189073.1 Gm21719 J3KMI9 J3KMI9_MOUSE uc292sbc.1 uc292sbc.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sbc.1 uc292sbc.2 
ENSMUST00000189080.2 Gm29481 ENSMUST00000189080.2 Gm29481 (from geneSymbol) AK077805 ENSMUST00000189080.1 uc287kmt.1 uc287kmt.2 uc287kmt.1 uc287kmt.2 
ENSMUST00000189100.2 Gm29232 ENSMUST00000189100.2 Gm29232 (from geneSymbol) AK005924 ENSMUST00000189100.1 uc289zlo.1 uc289zlo.2 uc289zlo.1 uc289zlo.2 
ENSMUST00000189116.3 1700010J16Rik ENSMUST00000189116.3 RIKEN cDNA 1700010J16 gene (from RefSeq NR_040579.1) ENSMUST00000189116.1 ENSMUST00000189116.2 NR_040579 uc007haq.1 uc007haq.2 uc007haq.3 uc007haq.4 uc007haq.1 uc007haq.2 uc007haq.3 uc007haq.4 
ENSMUST00000189117.2 Gm29645 ENSMUST00000189117.2 Gm29645 (from geneSymbol) ENSMUST00000189117.1 uc292thm.1 uc292thm.2 uc292thm.1 uc292thm.2 
ENSMUST00000189118.2 Scgb1b15 ENSMUST00000189118.2 secretoglobin, family 1B, member 15 (from RefSeq NM_001370879.1) A0A087WP50 A0A087WP50_MOUSE Abpa15_a17 ENSMUST00000189118.1 NM_001370879 Scgb1b15 Scgb1b17 uc291oha.1 uc291oha.2 Secreted steroid binding extracellular region biological_process uc291oha.1 uc291oha.2 
ENSMUST00000189125.2 Gm28550 ENSMUST00000189125.2 Gm28550 (from geneSymbol) ENSMUST00000189125.1 uc292tjw.1 uc292tjw.2 uc292tjw.1 uc292tjw.2 
ENSMUST00000189137.7 Trpc1 ENSMUST00000189137.7 transient receptor potential cation channel, subfamily C, member 1, transcript variant 1 (from RefSeq NM_011643.4) B2RPS7 B2RPS7_MOUSE ENSMUST00000189137.1 ENSMUST00000189137.2 ENSMUST00000189137.3 ENSMUST00000189137.4 ENSMUST00000189137.5 ENSMUST00000189137.6 NM_011643 Trpc1 uc009rbh.1 uc009rbh.2 uc009rbh.3 uc009rbh.4 Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Membrane ; Multi- pass membrane protein Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. ion channel activity calcium channel activity plasma membrane ion transport membrane integral component of membrane melanin biosynthetic process receptor complex positive regulation of release of sequestered calcium ion into cytosol regulation of cytosolic calcium ion concentration response to calcium ion transmembrane transport calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding uc009rbh.1 uc009rbh.2 uc009rbh.3 uc009rbh.4 
ENSMUST00000189147.2 Gm28386 ENSMUST00000189147.2 Gm28386 (from geneSymbol) AK158632 ENSMUST00000189147.1 uc287jny.1 uc287jny.2 uc287jny.1 uc287jny.2 
ENSMUST00000189150.2 Gm28856 ENSMUST00000189150.2 predicted gene 28856 (from RefSeq NR_151623.1) ENSMUST00000189150.1 NR_151623 uc287lno.1 uc287lno.2 uc287lno.1 uc287lno.2 
ENSMUST00000189155.5 Lrrc77 ENSMUST00000189155.5 Lrrc77 (from geneSymbol) A0A1B0GT72 A0A1B0GT72_MOUSE ENSMUST00000189155.1 ENSMUST00000189155.2 ENSMUST00000189155.3 ENSMUST00000189155.4 Gm29133 Lrrc77 uc290fzj.1 uc290fzj.2 uc290fzj.3 uc290fzj.1 uc290fzj.2 uc290fzj.3 
ENSMUST00000189170.7 Gm28300 ENSMUST00000189170.7 Gm28300 (from geneSymbol) DQ874391 ENSMUST00000189170.1 ENSMUST00000189170.2 ENSMUST00000189170.3 ENSMUST00000189170.4 ENSMUST00000189170.5 ENSMUST00000189170.6 uc029ygv.1 uc029ygv.2 uc029ygv.1 uc029ygv.2 
ENSMUST00000189178.3 Gm29186 ENSMUST00000189178.3 Gm29186 (from geneSymbol) ENSMUST00000189178.1 ENSMUST00000189178.2 uc287jcl.1 uc287jcl.2 uc287jcl.3 uc287jcl.1 uc287jcl.2 uc287jcl.3 
ENSMUST00000189181.7 Pgr ENSMUST00000189181.7 progesterone receptor (from RefSeq NM_008829.2) A6H6A5 E9QPW3 ENSMUST00000189181.1 ENSMUST00000189181.2 ENSMUST00000189181.3 ENSMUST00000189181.4 ENSMUST00000189181.5 ENSMUST00000189181.6 NM_008829 Nr3c3 PRGR_MOUSE Pr Q00175 uc009odo.1 uc009odo.2 This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC145807.1, AK054117.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-294 by ERK1/2 MAPK. Interacts with PRMT2 (By similarity). Isoform A interacts with NCOR2. Isoform B (but not isoform A) interacts with NCOA2 and NCOA1. Isoform B (but not isoform A) interacts with KLF9. Q00175; P19785: Esr1; NbExp=5; IntAct=EBI-346821, EBI-346765; Q00175; P42227: Stat3; NbExp=4; IntAct=EBI-346821, EBI-602878; Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity). Event=Alternative promoter usage; Named isoforms=2; Name=B; Synonyms=PRB, PR-B; IsoId=Q00175-1; Sequence=Displayed; Name=A; Synonyms=PRA, PR-A; IsoId=Q00175-2; Sequence=VSP_058743; Expression of isoform A and isoform B in mammary epithelial cells is temporally and spatially separated during normal mammary gland development. Isoform A and isoform B are expressed in the pituitary. Isoform A and isoform B are differentially expressed in the ovary and oviduct, and the level of expression is dependent on both the cell type and estrous cycle stage. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 is highly hormone- dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-82, Ser-163, Ser-191 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-163 and Ser-294, but not at Ser-191, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1 (By similarity). Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294 (By similarity). Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294 (By similarity). Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity). Infertile. Inability to ovulate, uterine hyperplasia and inflammation, severely limited mammary gland development and an impairment in the induction of a sexual behavioral response (PubMed:8603049). In isoform A-defective mice less oocytes are produced, only a subset of implantation-specific uterine epithelial target genes is regulated, and an increased progesterone-dependent proliferative activity of isoform B in the uterine epithelium is observed. Isoform B-defective mice showed unaffected ovulation (PubMed:10976068). Belongs to the nuclear hormone receptor family. NR3 subfamily. Sequence=AAA39971.1; Type=Frameshift; Evidence=; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ovulation from ovarian follicle epithelial cell maturation DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding steroid binding protein binding nucleus cytoplasm mitochondrion endoplasmic reticulum cytosol plasma membrane regulation of transcription, DNA-templated zinc ion binding positive regulation of cell proliferation lipid binding negative regulation of gene expression positive regulation of smooth muscle cell migration enzyme binding axon dendrite mammary gland development paracrine signaling response to cocaine hormone binding identical protein binding neuron projection negative regulation of apoptotic process dendritic spine perikaryon steroid hormone mediated signaling pathway sequence-specific DNA binding axon terminus positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding lung alveolus development regulation of epithelial cell proliferation progesterone receptor signaling pathway ATPase binding female mating behavior tertiary branching involved in mammary gland duct morphogenesis negative regulation of granulosa cell apoptotic process uc009odo.1 uc009odo.2 
ENSMUST00000189187.2 Gm28696 ENSMUST00000189187.2 Gm28696 (from geneSymbol) ENSMUST00000189187.1 uc292usi.1 uc292usi.2 uc292usi.1 uc292usi.2 
ENSMUST00000189190.2 Btbd35f23 ENSMUST00000189190.2 BTB domain containing 35, family member 23 (from RefSeq NM_001270667.1) A0A0R4J2B9 A0A0R4J2B9_MOUSE Btbd35f23 ENSMUST00000189190.1 NM_001270667 uc033jof.1 uc033jof.2 uc033jof.3 uc033jof.1 uc033jof.2 uc033jof.3 
ENSMUST00000189195.2 Gm28087 ENSMUST00000189195.2 Gm28087 (from geneSymbol) ENSMUST00000189195.1 uc292jym.1 uc292jym.2 uc292jym.1 uc292jym.2 
ENSMUST00000189201.2 Gm21244 ENSMUST00000189201.2 Belongs to the SPIN/STSY family. (from UniProt J3QK38) ENSMUST00000189201.1 Gm20826 Gm21244 J3QK38 J3QK38_MOUSE uc292sbo.1 uc292sbo.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sbo.1 uc292sbo.2 
ENSMUST00000189204.2 Gm16833 ENSMUST00000189204.2 predicted gene, 16833 (from RefSeq NR_045754.1) ENSMUST00000189204.1 NR_045754 uc009odq.1 uc009odq.2 uc009odq.3 uc009odq.4 uc009odq.1 uc009odq.2 uc009odq.3 uc009odq.4 
ENSMUST00000189206.2 ENSMUSG00000121321 ENSMUST00000189206.2 ENSMUSG00000121321 (from geneSymbol) AK015935 ENSMUST00000189206.1 uc292txr.1 uc292txr.2 uc292txr.1 uc292txr.2 
ENSMUST00000189207.2 Gm28254 ENSMUST00000189207.2 Gm28254 (from geneSymbol) ENSMUST00000189207.1 uc292tzt.1 uc292tzt.2 uc292tzt.1 uc292tzt.2 
ENSMUST00000189214.2 Gm28612 ENSMUST00000189214.2 Gm28612 (from geneSymbol) ENSMUST00000189214.1 uc292udg.1 uc292udg.2 uc292udg.1 uc292udg.2 
ENSMUST00000189215.7 Gm29303 ENSMUST00000189215.7 Gm29303 (from geneSymbol) ENSMUST00000189215.1 ENSMUST00000189215.2 ENSMUST00000189215.3 ENSMUST00000189215.4 ENSMUST00000189215.5 ENSMUST00000189215.6 uc292tre.1 uc292tre.2 uc292tre.1 uc292tre.2 
ENSMUST00000189220.7 Agfg1 ENSMUST00000189220.7 ArfGAP with FG repeats 1, transcript variant 1 (from RefSeq NM_010472.3) AGFG1_MOUSE ENSMUST00000189220.1 ENSMUST00000189220.2 ENSMUST00000189220.3 ENSMUST00000189220.4 ENSMUST00000189220.5 ENSMUST00000189220.6 Hrb NM_010472 O70448 Q8BQL5 Q8CDK9 Q8K2K6 Rip uc007bse.1 uc007bse.2 uc007bse.3 uc007bse.4 Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization. Interacts with FCHO1 (By similarity). Interacts with EPS15R and EPS15. Nucleus Cytoplasmic vesicle Note=Associated with the cytosolic surface of proacrosomic vesicles of early round spermatids. Event=Alternative splicing; Named isoforms=4; Name=4; IsoId=Q8K2K6-4; Sequence=Displayed; Name=1; IsoId=Q8K2K6-1; Sequence=VSP_017602; Name=2; IsoId=Q8K2K6-2; Sequence=VSP_010664; Name=3; IsoId=Q8K2K6-3; Sequence=VSP_010665; Expressed in the testes (at protein level). Highly expressed during spermiogenesis. Contains FG repeats. O-glycosylated. Mice have a normal life-span and show no apparent abnormalities. Females display normal fertility but males are infertile due to a lack of acrosome in their spermatozoa. acrosome assembly DNA binding GTPase activator activity nucleus multicellular organism development spermatogenesis spermatid nucleus differentiation cell differentiation cytoplasmic vesicle cell projection neuronal cell body intracellular membrane-bounded organelle positive regulation of GTPase activity intermediate filament organization metal ion binding uc007bse.1 uc007bse.2 uc007bse.3 uc007bse.4 
ENSMUST00000189221.3 Gm29246 ENSMUST00000189221.3 Gm29246 (from geneSymbol) ENSMUST00000189221.1 ENSMUST00000189221.2 uc287qvv.1 uc287qvv.2 uc287qvv.3 uc287qvv.1 uc287qvv.2 uc287qvv.3 
ENSMUST00000189224.2 Gm21413 ENSMUST00000189224.2 Gm21413 (from geneSymbol) ENSMUST00000189224.1 uc292tux.1 uc292tux.2 uc292tux.1 uc292tux.2 
ENSMUST00000189232.3 Gm29461 ENSMUST00000189232.3 predicted gene 29461 (from RefSeq NR_151613.1) ENSMUST00000189232.1 ENSMUST00000189232.2 NR_151613 uc287kto.1 uc287kto.2 uc287kto.3 uc287kto.1 uc287kto.2 uc287kto.3 
ENSMUST00000189238.2 Gm21173 ENSMUST00000189238.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK3) A0A087WRK3 A0A087WRK3_MOUSE BC100464 ENSMUST00000189238.1 Gm20817 Gm21173 Gm21497 Gm28553 uc292uox.1 uc292uox.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292uox.1 uc292uox.2 
ENSMUST00000189245.2 Gm28387 ENSMUST00000189245.2 Gm28387 (from geneSymbol) ENSMUST00000189245.1 uc287job.1 uc287job.2 uc287job.1 uc287job.2 
ENSMUST00000189250.2 Gm29194 ENSMUST00000189250.2 Gm29194 (from geneSymbol) ENSMUST00000189250.1 uc292sai.1 uc292sai.2 uc292sai.1 uc292sai.2 
ENSMUST00000189251.2 Gm28864 ENSMUST00000189251.2 Gm28864 (from geneSymbol) ENSMUST00000189251.1 uc290oua.1 uc290oua.2 uc290oua.1 uc290oua.2 
ENSMUST00000189253.2 Gm21721 ENSMUST00000189253.2 Belongs to the SPIN/STSY family. (from UniProt J3QMK7) ENSMUST00000189253.1 Gm21721 J3QMK7 J3QMK7_MOUSE uc292sdv.1 uc292sdv.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sdv.1 uc292sdv.2 
ENSMUST00000189255.7 ENSMUSG00000121639 ENSMUST00000189255.7 ENSMUSG00000121639 (from geneSymbol) ENSMUST00000189255.1 ENSMUST00000189255.2 ENSMUST00000189255.3 ENSMUST00000189255.4 ENSMUST00000189255.5 ENSMUST00000189255.6 uc292tzz.1 uc292tzz.2 uc292tzz.1 uc292tzz.2 
ENSMUST00000189257.7 Usp37 ENSMUST00000189257.7 ubiquitin specific peptidase 37, transcript variant 1 (from RefSeq NM_176972.4) A0A0R4J2D0 A0A0R4J2D0_MOUSE ENSMUST00000189257.1 ENSMUST00000189257.2 ENSMUST00000189257.3 ENSMUST00000189257.4 ENSMUST00000189257.5 ENSMUST00000189257.6 NM_176972 Usp37 uc007bmd.1 uc007bmd.2 uc007bmd.3 uc007bmd.4 Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence= Belongs to the peptidase C19 family. G1/S transition of mitotic cell cycle cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus regulation of DNA replication proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity protein kinase binding protein K11-linked deubiquitination thiol-dependent ubiquitinyl hydrolase activity protein K48-linked deubiquitination uc007bmd.1 uc007bmd.2 uc007bmd.3 uc007bmd.4 
ENSMUST00000189261.2 Gm28985 ENSMUST00000189261.2 Gm28985 (from geneSymbol) ENSMUST00000189261.1 uc292sus.1 uc292sus.2 uc292sus.1 uc292sus.2 
ENSMUST00000189268.7 Tbrg4 ENSMUST00000189268.7 transforming growth factor beta regulated gene 4, transcript variant 1 (from RefSeq NM_134011.3) ENSMUST00000189268.1 ENSMUST00000189268.2 ENSMUST00000189268.3 ENSMUST00000189268.4 ENSMUST00000189268.5 ENSMUST00000189268.6 FAKD4_MOUSE Kiaa0948 NM_134011 O89082 Q3TKZ4 Q6ZQ19 Q8C6D1 Q91YM4 uc287woa.1 uc287woa.2 Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression. Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91YM4-1; Sequence=Displayed; Name=2; IsoId=Q91YM4-2; Sequence=VSP_022461; Expression detected in spleen, testis, colon, heart, smooth muscle, kidney, brain, lung, liver, brown and white adipose tissue with highest expression in testis, heart, smooth muscle and brown adipose tissue. Belongs to the FAST kinase family. Sequence=AAC36538.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC36037.1; Type=Erroneous initiation; Evidence=; Sequence=BAC98055.1; Type=Erroneous initiation; Evidence=; protein kinase activity mitochondrion mitochondrial matrix protein phosphorylation mRNA metabolic process regulation of mitochondrial mRNA stability mitochondrial mRNA processing uc287woa.1 uc287woa.2 
ENSMUST00000189275.2 Npn2 ENSMUST00000189275.2 Npn2 (from geneSymbol) ENSMUST00000189275.1 Z31359 uc291dlm.1 uc291dlm.2 uc291dlm.1 uc291dlm.2 
ENSMUST00000189281.2 Gm28085 ENSMUST00000189281.2 Gm28085 (from geneSymbol) AK135342 ENSMUST00000189281.1 uc292jtp.1 uc292jtp.2 uc292jtp.1 uc292jtp.2 
ENSMUST00000189291.8 1700129L04Rik ENSMUST00000189291.8 1700129L04Rik (from geneSymbol) AK007316 ENSMUST00000189291.1 ENSMUST00000189291.2 ENSMUST00000189291.3 ENSMUST00000189291.4 ENSMUST00000189291.5 ENSMUST00000189291.6 ENSMUST00000189291.7 uc007xjp.1 uc007xjp.2 uc007xjp.3 uc007xjp.4 uc007xjp.5 uc007xjp.1 uc007xjp.2 uc007xjp.3 uc007xjp.4 uc007xjp.5 
ENSMUST00000189296.2 Gm29536 ENSMUST00000189296.2 predicted gene 29536 (from RefSeq NR_151519.1) ENSMUST00000189296.1 NR_151519 uc287joz.1 uc287joz.2 uc287joz.1 uc287joz.2 
ENSMUST00000189297.2 ENSMUSG00000121621 ENSMUST00000189297.2 ENSMUSG00000121621 (from geneSymbol) ENSMUST00000189297.1 uc292uiy.1 uc292uiy.2 uc292uiy.1 uc292uiy.2 
ENSMUST00000189302.3 Gm29254 ENSMUST00000189302.3 Gm29254 (from geneSymbol) AK028130 ENSMUST00000189302.1 ENSMUST00000189302.2 uc008wny.1 uc008wny.2 uc008wny.3 uc008wny.1 uc008wny.2 uc008wny.3 
ENSMUST00000189308.4 1700124L16Rik ENSMUST00000189308.4 1700124L16Rik (from geneSymbol) AK005768 ENSMUST00000189308.1 ENSMUST00000189308.2 ENSMUST00000189308.3 uc291ggw.1 uc291ggw.2 uc291ggw.3 uc291ggw.1 uc291ggw.2 uc291ggw.3 
ENSMUST00000189315.2 Gm20870 ENSMUST00000189315.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE ENSMUST00000189315.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292ujp.1 uc292ujp.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292ujp.1 uc292ujp.2 
ENSMUST00000189318.2 Gm29338 ENSMUST00000189318.2 Gm29338 (from geneSymbol) ENSMUST00000189318.1 uc292uvk.1 uc292uvk.2 uc292uvk.1 uc292uvk.2 
ENSMUST00000189321.2 Gm29206 ENSMUST00000189321.2 Gm29206 (from geneSymbol) ENSMUST00000189321.1 uc292twv.1 uc292twv.2 uc292twv.1 uc292twv.2 
ENSMUST00000189326.2 Gm2109 ENSMUST00000189326.2 predicted gene 2109 (from RefSeq NR_046066.1) ENSMUST00000189326.1 NR_046066 uc029xfc.1 uc029xfc.2 uc029xfc.3 uc029xfc.1 uc029xfc.2 uc029xfc.3 
ENSMUST00000189331.2 Gm28289 ENSMUST00000189331.2 Gm28289 (from geneSymbol) ENSMUST00000189331.1 uc287pqv.1 uc287pqv.2 uc287pqv.1 uc287pqv.2 
ENSMUST00000189333.7 Gm28891 ENSMUST00000189333.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRF5) 1700040F15Rik A0A087WRF5 A0A087WRF5_MOUSE AK077064 ENSMUST00000189333.1 ENSMUST00000189333.2 ENSMUST00000189333.3 ENSMUST00000189333.4 ENSMUST00000189333.5 ENSMUST00000189333.6 Gm20792 Gm20837 Gm20838 Gm21094 Gm21256 Gm21739 Gm21861 Gm28891 uc292tvw.1 uc292tvw.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc292tvw.1 uc292tvw.2 
ENSMUST00000189334.4 2810405F17Rik ENSMUST00000189334.4 RIKEN cDNA 2810405F17 gene (from RefSeq NR_190112.1) ENSMUST00000189334.1 ENSMUST00000189334.2 ENSMUST00000189334.3 NR_190112 uc290qzz.1 uc290qzz.2 uc290qzz.3 uc290qzz.4 uc290qzz.1 uc290qzz.2 uc290qzz.3 uc290qzz.4 
ENSMUST00000189342.2 Gm28244 ENSMUST00000189342.2 Gm28244 (from geneSymbol) ENSMUST00000189342.1 uc292ste.1 uc292ste.2 uc292ste.1 uc292ste.2 
ENSMUST00000189344.8 Gm29301 ENSMUST00000189344.8 Gm29301 (from geneSymbol) ENSMUST00000189344.1 ENSMUST00000189344.2 ENSMUST00000189344.3 ENSMUST00000189344.4 ENSMUST00000189344.5 ENSMUST00000189344.6 ENSMUST00000189344.7 uc292trp.1 uc292trp.2 uc292trp.3 uc292trp.1 uc292trp.2 uc292trp.3 
ENSMUST00000189346.2 Gm20903 ENSMUST00000189346.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE BC049626 ENSMUST00000189346.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292umh.1 uc292umh.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292umh.1 uc292umh.2 
ENSMUST00000189350.2 Gm28482 ENSMUST00000189350.2 Gm28482 (from geneSymbol) ENSMUST00000189350.1 uc292ujm.1 uc292ujm.2 uc292ujm.1 uc292ujm.2 
ENSMUST00000189354.7 Gm21209 ENSMUST00000189354.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WQA3) A0A087WQA3 A0A087WQA3_MOUSE ENSMUST00000189354.1 ENSMUST00000189354.2 ENSMUST00000189354.3 ENSMUST00000189354.4 ENSMUST00000189354.5 ENSMUST00000189354.6 FJ541091 Gm20843 Gm20888 Gm20937 Gm21209 Gm21518 uc292tly.1 uc292tly.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292tly.1 uc292tly.2 
ENSMUST00000189359.7 Mdfic ENSMUST00000189359.7 MyoD family inhibitor domain containing (from RefSeq NM_175088.5) ENSMUST00000189359.1 ENSMUST00000189359.2 ENSMUST00000189359.3 ENSMUST00000189359.4 ENSMUST00000189359.5 ENSMUST00000189359.6 Kdt1 MDFIC_MOUSE Mdfic NM_175088 Q3T9H3 Q6NXM1 Q8BJS3 Q8BX65 uc009azc.1 uc009azc.2 uc009azc.3 This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, which in human have been shown to have different subcellular localization. [provided by RefSeq, Jul 2008]. Sequence Note: An AUG translation start codon is selected for this RefSeq based on its conservation with the homologous human isoform, p32. Studies in PMID:10671520 demonstrate the existence of a longer human isoform, p40, which can initiate translation from an upstream non-AUG (GUG) start codon. Possible in-frame, upstream GUG start codons are also present in mouse, which could extend the protein N-terminal by 82, 106 or 117 aa; however, these extensions are not conserved with the human p40 N-terminal. ##Evidence-Data-START## Transcript exon combination :: SRR1660821.50847.1, AK165016.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation. Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin-regulation of the WNT and JNK signaling pathways. Involved in the development of lymphatic vessel valves (PubMed:35235341). It is required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (By similarity). Interacts with HAND1; leading to sequester HAND1 into the nucleolus and prevent its activity (PubMed:17891141). The C-terminus interacts with ZIC2 (PubMed:15207726, PubMed:15465018). The C-terminus interacts with AXIN1, the histidine-rich region of CCNT1/cyclin-T and weakly with LEF1. Interacts with CCNT2 (By similarity). Interacts with GATA2 (PubMed:35235341). Cytoplasm Cell membrane ; Single-pass membrane protein Secreted Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8BX65-1; Sequence=Displayed; Name=2 ; IsoId=Q8BX65-2; Sequence=VSP_052336, VSP_052337; In the embryo, robust expression is detected between 16.5 and 18.5 dpc in lung, kidney, and salivary glands. In the developing cardiovascular system, it is detected in lymphatic and cardiac valves (at protein level). The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm (By similarity). The cysteine-rich C- terminus mediates protein-protein interactions, including interaction with HIV-1 Tat, transcription factors, AXIN1, CCNT1 (By similarity). Belongs to the MDFI family. Sequence=AAH67006.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC37840.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE43047.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding nucleus nucleolus cytoplasm activation of JUN kinase activity transcription factor binding regulation of Wnt signaling pathway cyclin binding Tat protein binding negative regulation of protein import into nucleus negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of viral transcription uc009azc.1 uc009azc.2 uc009azc.3 
ENSMUST00000189360.2 Gm28233 ENSMUST00000189360.2 Gm28233 (from geneSymbol) ENSMUST00000189360.1 uc292tpm.1 uc292tpm.2 uc292tpm.1 uc292tpm.2 
ENSMUST00000189363.2 Gm29088 ENSMUST00000189363.2 Gm29088 (from geneSymbol) ENSMUST00000189363.1 uc287kzn.1 uc287kzn.2 uc287kzn.1 uc287kzn.2 
ENSMUST00000189365.2 Gm29363 ENSMUST00000189365.2 Gm29363 (from geneSymbol) ENSMUST00000189365.1 uc292sds.1 uc292sds.2 uc292sds.1 uc292sds.2 
ENSMUST00000189366.2 Gm28561 ENSMUST00000189366.2 Gm28561 (from geneSymbol) ENSMUST00000189366.1 uc292uam.1 uc292uam.2 uc292uam.1 uc292uam.2 
ENSMUST00000189379.7 Gm28520 ENSMUST00000189379.7 Gm28520 (from geneSymbol) ENSMUST00000189379.1 ENSMUST00000189379.2 ENSMUST00000189379.3 ENSMUST00000189379.4 ENSMUST00000189379.5 ENSMUST00000189379.6 uc292szk.1 uc292szk.2 uc292szk.1 uc292szk.2 
ENSMUST00000189381.2 Gm28192 ENSMUST00000189381.2 Gm28192 (from geneSymbol) ENSMUST00000189381.1 uc288ekn.1 uc288ekn.2 uc288ekn.1 uc288ekn.2 
ENSMUST00000189387.2 Gm29008 ENSMUST00000189387.2 Gm29008 (from geneSymbol) ENSMUST00000189387.1 LF195871 uc291iuc.1 uc291iuc.2 uc291iuc.1 uc291iuc.2 
ENSMUST00000189394.3 Gm19589 ENSMUST00000189394.3 predicted gene, 19589 (from RefSeq NR_037971.2) ENSMUST00000189394.1 ENSMUST00000189394.2 NR_037971 uc007bys.1 uc007bys.2 uc007bys.3 uc007bys.4 uc007bys.5 uc007bys.1 uc007bys.2 uc007bys.3 uc007bys.4 uc007bys.5 
ENSMUST00000189399.2 Gm28771 ENSMUST00000189399.2 Gm28771 (from geneSymbol) ENSMUST00000189399.1 uc292teg.1 uc292teg.2 uc292teg.1 uc292teg.2 
ENSMUST00000189400.7 Paqr8 ENSMUST00000189400.7 progestin and adipoQ receptor family member VIII, transcript variant 1 (from RefSeq NM_028829.4) ENSMUST00000189400.1 ENSMUST00000189400.2 ENSMUST00000189400.3 ENSMUST00000189400.4 ENSMUST00000189400.5 ENSMUST00000189400.6 Mprb NM_028829 PAQR8_MOUSE Paqr8 Q3UHI5 Q80ZE5 Q8C891 Q8CCW9 Q9DA71 uc007ald.1 uc007ald.2 uc007ald.3 Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway (By similarity). May be involved in oocyte maturation (PubMed:12601167). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (By similarity). Cell membrane ; Multi-pass membrane protein Note=Colocalizes with a lysosomal protein CTSD/cathepsin D. Expressed in brain and testis. Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). Belongs to the ADIPOR family. Sequence=BAC27629.1; Type=Frameshift; Evidence=; steroid hormone receptor activity steroid binding Golgi apparatus plasma membrane multicellular organism development lipid binding membrane integral component of membrane cell differentiation signaling receptor activity steroid hormone mediated signaling pathway oogenesis response to steroid hormone uc007ald.1 uc007ald.2 uc007ald.3 
ENSMUST00000189404.2 Gm28151 ENSMUST00000189404.2 Gm28151 (from geneSymbol) ENSMUST00000189404.1 uc287hwx.1 uc287hwx.2 uc287hwx.1 uc287hwx.2 
ENSMUST00000189405.7 4933436I20Rik ENSMUST00000189405.7 4933436I20Rik (from geneSymbol) AK016047 ENSMUST00000189405.1 ENSMUST00000189405.2 ENSMUST00000189405.3 ENSMUST00000189405.4 ENSMUST00000189405.5 ENSMUST00000189405.6 uc287juc.1 uc287juc.2 uc287juc.1 uc287juc.2 
ENSMUST00000189410.2 Gm17767 ENSMUST00000189410.2 predicted gene, 17767 (from RefSeq NR_151621.1) ENSMUST00000189410.1 NR_151621 uc007axq.1 uc007axq.2 uc007axq.3 uc007axq.1 uc007axq.2 uc007axq.3 
ENSMUST00000189413.7 Kif14 ENSMUST00000189413.7 kinesin family member 14 (from RefSeq NM_001287179.2) ENSMUST00000189413.1 ENSMUST00000189413.2 ENSMUST00000189413.3 ENSMUST00000189413.4 ENSMUST00000189413.5 ENSMUST00000189413.6 KIF14_MOUSE Kif14 L0N7N1 NM_001287179 uc007cuv.1 uc007cuv.2 uc007cuv.3 uc007cuv.4 Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (PubMed:24949858). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (By similarity). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (By similarity). Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (By similarity). During late neurogenesis, regulates the cerebellar and cerebral cortex development and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (PubMed:23308235, PubMed:24931760). Also is required for chromosome congression and alignment during mitotic cell cycle process (By similarity). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (By similarity). Kinetic parameters: KM=62 uM for ATP ; KM=33 uM for ATP (in the presence of microtubule) ; Directly interacts with PRC1 within a complex also containing KIF4A, KIF20A and KIF23; targets to the central spindle. Directly interacts with CIT depending on the activation state of the kinase (stronger interaction with the kinase-dead form); targets to the midbody. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation (By similarity). Interacts with AKT1; the interaction is detected in the plasma membrane upon INS stimulation and promotes AKT1 phosphorylation. Interacts with SVIL; at midbody during cytokinesis. Interacts with RADIL (via PDZ domain); recruits RADIL to the microtubule network restricting RADIL from interaction with activated RAP1A. Nucleus Cytoplasm Cytoplasm, cytoskeleton, spindle Midbody Note=Nuclear localization observed during interphase. Nuclear localization triggered by entry into mitosis. Cytoplasmic in interphase. Cytoplasmic in metaphase cells. From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring. The kinesin motor domain binds to microtubules with high affinity and has a robust ATPase activity but a very slow motility. The kinesin motor domain protects microtubules from cold depolymerization. Binds to each tubulin heterodimer resulting in a microtubule complexes. Binds at the tubulin intradimer interface, at the crest of the protofilament, and orients slightly toward the next protofilament. The lag homozygous mutant mice that lack detectable Kif14 expression are indistinguishable from normal littermates at birth. At P10, mutants exhibit an overt ataxic phenotype that increased in severity over time. At P12, lag homozygous mutant mice are unable to stand for 10 s on a narrow platform. Their gait is wide and uncoordinated, and they frequently fell on their backs while walking. These defects in voluntary movement control, posture and balance are accompanied by progressive weakness and failure to gain body weight. By P14, the homozygous mutants in a litter could be identified by their small size and uncontrolled movements. The homozygous mutants all died by P21. The lag homozygous mutant mice also display a flathead, a reduction in brain size, slender optic nerves, and a translucent spinal cord. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding regulation of cell growth microtubule motor activity ATP binding nucleus cytoplasm spindle cytosol cytoskeleton kinesin complex microtubule plasma membrane microtubule-based movement mitotic metaphase plate congression microtubule binding positive regulation of cell proliferation ATP-dependent microtubule motor activity, plus-end-directed regulation of G2/M transition of mitotic cell cycle tubulin binding membrane ATPase activity protein kinase binding cerebellar granular layer structural organization cerebellar Purkinje cell layer structural organization cerebellar cortex development hippocampus development olfactory bulb development cell proliferation in forebrain cerebral cortex development regulation of cell adhesion PDZ domain binding regulation of cell migration midbody cytoskeleton-dependent intracellular transport SCF-dependent proteasomal ubiquitin-dependent protein catabolic process regulation of myelination activation of protein kinase activity positive regulation of cytokinesis regulation of Rap protein signal transduction negative regulation of integrin activation substrate adhesion-dependent cell spreading negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process establishment of protein localization spindle midzone cell division Flemming body regulation of cell maturation regulation of G1/S transition of mitotic cell cycle microtubule depolymerization uc007cuv.1 uc007cuv.2 uc007cuv.3 uc007cuv.4 
ENSMUST00000189417.2 Gm28741 ENSMUST00000189417.2 Gm28741 (from geneSymbol) ENSMUST00000189417.1 uc292usy.1 uc292usy.2 uc292usy.1 uc292usy.2 
ENSMUST00000189421.2 Gm29425 ENSMUST00000189421.2 Gm29425 (from geneSymbol) ENSMUST00000189421.1 uc292uhv.1 uc292uhv.2 uc292uhv.1 uc292uhv.2 
ENSMUST00000189422.7 Gm20937 ENSMUST00000189422.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WQA3) A0A087WQA3 A0A087WQA3_MOUSE ENSMUST00000189422.1 ENSMUST00000189422.2 ENSMUST00000189422.3 ENSMUST00000189422.4 ENSMUST00000189422.5 ENSMUST00000189422.6 FJ541091 Gm20843 Gm20888 Gm20937 Gm21209 Gm21518 uc292uew.1 uc292uew.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292uew.1 uc292uew.2 
ENSMUST00000189428.2 Gm28509 ENSMUST00000189428.2 Gm28509 (from geneSymbol) ENSMUST00000189428.1 uc292sex.1 uc292sex.2 uc292sex.1 uc292sex.2 
ENSMUST00000189429.2 Gm29392 ENSMUST00000189429.2 Gm29392 (from geneSymbol) ENSMUST00000189429.1 uc292uzi.1 uc292uzi.2 uc292uzi.1 uc292uzi.2 
ENSMUST00000189438.2 Gm29671 ENSMUST00000189438.2 Gm29671 (from geneSymbol) ENSMUST00000189438.1 uc292tdw.1 uc292tdw.2 uc292tdw.1 uc292tdw.2 
ENSMUST00000189441.2 9230112E08Rik ENSMUST00000189441.2 9230112E08Rik (from geneSymbol) BC057100 ENSMUST00000189441.1 uc012cmh.1 uc012cmh.2 uc012cmh.3 uc012cmh.1 uc012cmh.2 uc012cmh.3 
ENSMUST00000189444.2 Gm21723 ENSMUST00000189444.2 Gm21723 (from geneSymbol) ENSMUST00000189444.1 FJ386436 uc292sxr.1 uc292sxr.2 uc292sxr.1 uc292sxr.2 
ENSMUST00000189446.7 Rbp2 ENSMUST00000189446.7 Intracellular transport of retinol. (from UniProt Q08652) AK003312 Crbpii ENSMUST00000189446.1 ENSMUST00000189446.2 ENSMUST00000189446.3 ENSMUST00000189446.4 ENSMUST00000189446.5 ENSMUST00000189446.6 Q08652 Q9D1N1 RET2_MOUSE uc292jwt.1 uc292jwt.2 Intracellular transport of retinol. Cytoplasm. Expressed in prenatal liver, intestine and lung, and in adult intestine. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. retinoid metabolic process retinoid binding cytoplasm cytosol lipid binding retinal binding retinol binding uc292jwt.1 uc292jwt.2 
ENSMUST00000189454.3 Gm7356 ENSMUST00000189454.3 predicted gene 7356 (from RefSeq NM_001378269.1) A0A3B2WD63 A0A3B2WD63_MOUSE ENSMUST00000189454.1 ENSMUST00000189454.2 Gm7356 NM_001378269 uc289hea.1 uc289hea.2 May play a role in sperm motility, especially in the regulation of flagellar function. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily. protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation intracellular signal transduction uc289hea.1 uc289hea.2 
ENSMUST00000189455.2 Gm21497 ENSMUST00000189455.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK3) A0A087WRK3 A0A087WRK3_MOUSE ENSMUST00000189455.1 Gm20817 Gm21173 Gm21497 Gm28553 uc292twy.1 uc292twy.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292twy.1 uc292twy.2 
ENSMUST00000189457.2 H3c11 ENSMUST00000189457.2 H3 clustered histone 11 (from RefSeq NM_178207.2) ENSMUST00000189457.1 H3.1-221 H3.1-291 H3.1-I H31_MOUSE H3a H3c1 H3c10 H3c11 H3c8 H3g H3h H3i Hist1h3a Hist1h3g Hist1h3h Hist1h3i NM_178207 P02295 P02296 P16106 P68433 Q05A97 Q3B7Z8 Q3B7Z9 Q5T009 uc007prj.1 uc007prj.2 uc007prj.3 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with TONSL; CHAF1A; CHAF1B; MCM2 and DNAJC9 (By similarity). P68433; P83917: Cbx1; NbExp=6; IntAct=EBI-79743, EBI-78119; P68433; Q8WTS6: SETD7; Xeno; NbExp=2; IntAct=EBI-79743, EBI-1268586; Nucleus. Chromosome. Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity). Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys- 10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Hydroxybutyrylation of histones is induced by starvation. It is linked to gene activation and may replace histone acetylation on the promoter of specific genes in response to fasting. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (PubMed:30867594). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (PubMed:30867594). Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission- independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity). Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. This histone is only present in mammals. Belongs to the histone H3 family. nuclear chromosome nucleosome nuclear nucleosome DNA binding protein binding nucleus nucleoplasm chromosome nucleosome assembly DNA replication-dependent nucleosome assembly macromolecular complex protein heterodimerization activity protein heterotetramerization regulation of gene silencing uc007prj.1 uc007prj.2 uc007prj.3 
ENSMUST00000189459.2 Gm36782 ENSMUST00000189459.2 Gm36782 (from geneSymbol) ENSMUST00000189459.1 uc292tfg.1 uc292tfg.2 uc292tfg.1 uc292tfg.2 
ENSMUST00000189463.2 Gm21394 ENSMUST00000189463.2 predicted gene, 21394 (from RefSeq NM_001378412.1) ENSMUST00000189463.1 Gm21394 MGC107098 NM_001378412 Q497R7 Q497R7_MOUSE uc292uvg.1 uc292uvg.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292uvg.1 uc292uvg.2 
ENSMUST00000189475.2 Gm29275 ENSMUST00000189475.2 Gm29275 (from geneSymbol) ENSMUST00000189475.1 uc292thi.1 uc292thi.2 uc292thi.1 uc292thi.2 
ENSMUST00000189480.2 Gm28139 ENSMUST00000189480.2 Gm28139 (from geneSymbol) ENSMUST00000189480.1 uc287run.1 uc287run.2 uc287run.1 uc287run.2 
ENSMUST00000189481.2 Gm29491 ENSMUST00000189481.2 Gm29491 (from geneSymbol) ENSMUST00000189481.1 uc287oui.1 uc287oui.2 uc287oui.1 uc287oui.2 
ENSMUST00000189482.2 Ovol3 ENSMUST00000189482.2 ovo like zinc finger 3 (from RefSeq NM_001289817.1) D3YYM0 ENSMUST00000189482.1 NM_001289817 OVOL3_MOUSE uc291ntz.1 uc291ntz.2 May act as a transcription regulator. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding nucleus epidermal cell differentiation sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding uc291ntz.1 uc291ntz.2 
ENSMUST00000189485.2 Gm29131 ENSMUST00000189485.2 Gm29131 (from geneSymbol) ENSMUST00000189485.1 uc292tvj.1 uc292tvj.2 uc292tvj.1 uc292tvj.2 
ENSMUST00000189488.3 Ccdc162 ENSMUST00000189488.3 coiled-coil domain containing 162 (from RefSeq NM_001358562.1) A0A087WRU3 CC162_MOUSE Ccdc162 ENSMUST00000189488.1 ENSMUST00000189488.2 NM_001358562 Q0VG85 Q3UUY5 Q3V339 uc056ygq.1 uc056ygq.2 uc056ygq.3 uc056ygq.4 uc056ygq.5 Event=Alternative splicing; Named isoforms=4; Name=5; IsoId=Q0VG85-5; Sequence=Displayed; Name=2; IsoId=Q0VG85-2; Sequence=VSP_040687, VSP_040690, VSP_040691, VSP_040692; Name=3; IsoId=Q0VG85-3; Sequence=VSP_040688, VSP_040689; Name=4; IsoId=Q0VG85-6; Sequence=VSP_059001; molecular_function cellular_component biological_process uc056ygq.1 uc056ygq.2 uc056ygq.3 uc056ygq.4 uc056ygq.5 
ENSMUST00000189495.2 Gm21419 ENSMUST00000189495.2 Gm21419 (from geneSymbol) ENSMUST00000189495.1 uc292tva.1 uc292tva.2 uc292tva.1 uc292tva.2 
ENSMUST00000189499.2 Gm10538 ENSMUST00000189499.2 predicted gene 10538 (from RefSeq NR_045892.1) ENSMUST00000189499.1 NR_045892 uc029qth.1 uc029qth.2 uc029qth.3 uc029qth.1 uc029qth.2 uc029qth.3 
ENSMUST00000189500.2 Gm29175 ENSMUST00000189500.2 Gm29175 (from geneSymbol) ENSMUST00000189500.1 uc291yfm.1 uc291yfm.2 uc291yfm.1 uc291yfm.2 
ENSMUST00000189502.7 Gm28600 ENSMUST00000189502.7 Gm28600 (from geneSymbol) ENSMUST00000189502.1 ENSMUST00000189502.2 ENSMUST00000189502.3 ENSMUST00000189502.4 ENSMUST00000189502.5 ENSMUST00000189502.6 uc292txj.1 uc292txj.2 uc292txj.1 uc292txj.2 
ENSMUST00000189511.2 Gm28269 ENSMUST00000189511.2 predicted gene 28269 (from RefSeq NR_163859.1) A0A087WSG3 A0A087WSG3_MOUSE ENSMUST00000189511.1 Gm28269 NR_163859 uc292nml.1 uc292nml.2 membrane integral component of membrane uc292nml.1 uc292nml.2 
ENSMUST00000189514.2 Gm29183 ENSMUST00000189514.2 RIKEN cDNA 6030407O03 gene (from RefSeq NR_045311.1) ENSMUST00000189514.1 NR_045311 uc007bld.1 uc007bld.2 uc007bld.3 uc007bld.4 uc007bld.1 uc007bld.2 uc007bld.3 uc007bld.4 
ENSMUST00000189517.2 Rplp1rt ENSMUST00000189517.2 Plays an important role in the elongation step of protein synthesis. (from UniProt A0A494BA26) A0A494BA26 A0A494BA26_MOUSE BC158067 ENSMUST00000189517.1 Gm5244 Rplp1rt uc289rdf.1 uc289rdf.2 Plays an important role in the elongation step of protein synthesis. Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein P1/P2 family. structural constituent of ribosome ribosome translational elongation uc289rdf.1 uc289rdf.2 
ENSMUST00000189518.2 Gm20890 ENSMUST00000189518.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WR99) A0A087WR99 A0A087WR99_MOUSE ENSMUST00000189518.1 Gm20890 Gm21488 uc292ssq.1 uc292ssq.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292ssq.1 uc292ssq.2 
ENSMUST00000189525.2 Gm28930 ENSMUST00000189525.2 Gm28930 (from geneSymbol) ENSMUST00000189525.1 uc292uzz.1 uc292uzz.2 uc292uzz.1 uc292uzz.2 
ENSMUST00000189531.2 H2al1b ENSMUST00000189531.2 H2A histone family member L1B (from RefSeq NM_001242947.1) A0A087WP11 A0A087WP11_MOUSE ENSMUST00000189531.1 Gm14474 H2al1b NM_001242947 uc029xic.1 uc029xic.2 uc029xic.3 The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus Belongs to the histone H2A family. nucleosome nuclear chromatin DNA binding nucleus chromosome chromatin organization protein heterodimerization activity uc029xic.1 uc029xic.2 uc029xic.3 
ENSMUST00000189532.2 Gm28566 ENSMUST00000189532.2 Gm28566 (from geneSymbol) ENSMUST00000189532.1 uc292tke.1 uc292tke.2 uc292tke.1 uc292tke.2 
ENSMUST00000189538.3 1700095B10Rik ENSMUST00000189538.3 1700095B10Rik (from geneSymbol) AK006812 ENSMUST00000189538.1 ENSMUST00000189538.2 uc290ykh.1 uc290ykh.2 uc290ykh.3 uc290ykh.1 uc290ykh.2 uc290ykh.3 
ENSMUST00000189540.7 Mei1 ENSMUST00000189540.7 Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes. (from UniProt Q9D4I2) AY270177 B2RQ44 ENSMUST00000189540.1 ENSMUST00000189540.2 ENSMUST00000189540.3 ENSMUST00000189540.4 ENSMUST00000189540.5 ENSMUST00000189540.6 F8WHB9 MEII1_MOUSE Mei1 Q9D4I2 uc007wyd.1 uc007wyd.2 uc007wyd.3 uc007wyd.4 Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D4I2-1; Sequence=Displayed; Name=2 ; IsoId=Q9D4I2-2; Sequence=VSP_052892; Strongly expressed in testis, weakly in brain, and not detected in spleen, liver, kidney, small intestine or colon. Highly expressed in 17 dpc ovaries. Expression is significantly reduced in newborn ovaries, and is undetectable in ovaries from 5 day and 8 week old mice. Mice are infertile due to meiotic arrest caused by defects in chromosome synapsis. They lack zygotene Rad51 foci, and are likely to be deficient in meiotic double-strand break (DSB) formation. In addition, mutant spermatocytes exhibit meiotic arrest at entry into pachynema, whereas oocytes progress to an abnormal metaphase I. MEI1-deficient oocytes are capable of fertilization. The zygotes are capable of initiating embryonic development but mostly arrest at the 2- 4 cell stage. Among all the zygotes, approximately 5% are androgenetic and do not contain maternal chromosomes (PubMed:30388401). cell male meiosis I gamete generation spermatid development meiotic telomere clustering meiotic cell cycle uc007wyd.1 uc007wyd.2 uc007wyd.3 uc007wyd.4 
ENSMUST00000189543.7 Gm21477 ENSMUST00000189543.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE BC049626 ENSMUST00000189543.1 ENSMUST00000189543.2 ENSMUST00000189543.3 ENSMUST00000189543.4 ENSMUST00000189543.5 ENSMUST00000189543.6 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc029ygn.1 uc029ygn.2 uc029ygn.3 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc029ygn.1 uc029ygn.2 uc029ygn.3 
ENSMUST00000189546.7 1810018F18Rik ENSMUST00000189546.7 RIKEN cDNA 1810018F18 gene (from RefSeq NR_038140.1) ENSMUST00000189546.1 ENSMUST00000189546.2 ENSMUST00000189546.3 ENSMUST00000189546.4 ENSMUST00000189546.5 ENSMUST00000189546.6 NR_038140 uc008ias.1 uc008ias.2 uc008ias.1 uc008ias.2 
ENSMUST00000189550.2 Gm20812 ENSMUST00000189550.2 Belongs to the SPIN/STSY family. (from UniProt J3QPZ4) ENSMUST00000189550.1 Gm20812 Gm20877 J3QPZ4 J3QPZ4_MOUSE uc292sgk.1 uc292sgk.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sgk.1 uc292sgk.2 
ENSMUST00000189554.2 Gm28772 ENSMUST00000189554.2 Gm28772 (from geneSymbol) ENSMUST00000189554.1 uc292tei.1 uc292tei.2 uc292tei.1 uc292tei.2 
ENSMUST00000189555.2 Gm29348 ENSMUST00000189555.2 Gm29348 (from geneSymbol) ENSMUST00000189555.1 uc287lfp.1 uc287lfp.2 uc287lfp.1 uc287lfp.2 
ENSMUST00000189560.2 Gm28319 ENSMUST00000189560.2 Gm28319 (from geneSymbol) ENSMUST00000189560.1 uc287hyh.1 uc287hyh.2 uc287hyh.1 uc287hyh.2 
ENSMUST00000189566.2 Gm17412 ENSMUST00000189566.2 Gm17412 (from geneSymbol) ENSMUST00000189566.1 FJ386434 uc292qin.1 uc292qin.2 uc292qin.1 uc292qin.2 
ENSMUST00000189567.2 Gm28963 ENSMUST00000189567.2 Gm28963 (from geneSymbol) ENSMUST00000189567.1 uc292tuf.1 uc292tuf.2 uc292tuf.1 uc292tuf.2 
ENSMUST00000189569.2 Gm29549 ENSMUST00000189569.2 Gm29549 (from geneSymbol) ENSMUST00000189569.1 uc292tya.1 uc292tya.2 uc292tya.1 uc292tya.2 
ENSMUST00000189573.2 Gm28540 ENSMUST00000189573.2 Gm28540 (from geneSymbol) ENSMUST00000189573.1 uc292ups.1 uc292ups.2 uc292ups.1 uc292ups.2 
ENSMUST00000189574.7 A230077H06Rik ENSMUST00000189574.7 A230077H06Rik (from geneSymbol) AK038939 ENSMUST00000189574.1 ENSMUST00000189574.2 ENSMUST00000189574.3 ENSMUST00000189574.4 ENSMUST00000189574.5 ENSMUST00000189574.6 uc291oua.1 uc291oua.2 uc291oua.1 uc291oua.2 
ENSMUST00000189577.7 Gm21094 ENSMUST00000189577.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRF5) 1700040F15Rik A0A087WRF5 A0A087WRF5_MOUSE AK077064 ENSMUST00000189577.1 ENSMUST00000189577.2 ENSMUST00000189577.3 ENSMUST00000189577.4 ENSMUST00000189577.5 ENSMUST00000189577.6 Gm20792 Gm20837 Gm20838 Gm21094 Gm21256 Gm21739 Gm21861 Gm28891 uc292syk.1 uc292syk.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc292syk.1 uc292syk.2 
ENSMUST00000189579.2 Gm28839 ENSMUST00000189579.2 Gm28839 (from geneSymbol) ENSMUST00000189579.1 uc292uiv.1 uc292uiv.2 uc292uiv.1 uc292uiv.2 
ENSMUST00000189584.2 Gm28365 ENSMUST00000189584.2 Gm28365 (from geneSymbol) ENSMUST00000189584.1 uc292uxq.1 uc292uxq.2 uc292uxq.1 uc292uxq.2 
ENSMUST00000189588.7 Tmem108 ENSMUST00000189588.7 transmembrane protein 108, transcript variant 1 (from RefSeq NM_178638.4) ENSMUST00000189588.1 ENSMUST00000189588.2 ENSMUST00000189588.3 ENSMUST00000189588.4 ENSMUST00000189588.5 ENSMUST00000189588.6 NM_178638 Q80WR9 Q8BHE4 TM108_MOUSE Tmem108 uc009rgy.1 uc009rgy.2 uc009rgy.3 uc009rgy.4 Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons (PubMed:28096412). Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport (PubMed:17287360). In hippocampal neurons, required for BDNF- dependent dendrite outgrowth (PubMed:21849472). Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes (PubMed:21849472, PubMed:27605705). Interacts with DST (isoform 1) (PubMed:17287360). Interacts with SH3GL2 (PubMed:21849472). Interacts (via N-terminus) with CYFIP1 and CYFIP2; the interactions associate TMEM108 with the WAVE1 complex (PubMed:27605705). Membrane ; Multi- pass membrane protein Postsynaptic density Endosome membrane Cell projection, axon Cell projection, dendrite Early endosome Expressed in the nervous system tissues, such as hippocampus and spinal cord, is barely detectable in peripheral tissues such as heart, lung, liver, kidney and muscle (PubMed:17287360, PubMed:28096412). In brain, highly expressed in dentate gyrus neurons and expressed in cortex, olfactory bulb, ammon's horn, cerebellum, hypothalamus and striatum (PubMed:28096412, PubMed:21849472). In brain, detectable as early as 12 dpc and the level increases persistently through later embryonic stages to the adult age (PubMed:17287360). In the hippocampus, undetectable at postnatal day 1 (P1), detected at P7, the levels peak between P15 and P21 to remain at a high level during adulthood (PubMed:28096412). Glycosylated. Mutants are viable and show no difference in body weight or locomotor activity (PubMed:28096412). They are impaired in sensorimotor gating, spatial recognition memory and suppressed fear memory consolidation (PubMed:28096412). Spine density of dentate gyrus granule neurons is significantly reduced compare to wild-type animals, which is associated with decreased spine width and increased spine length (PubMed:28096412). protein binding endosome early endosome plasma membrane receptor-mediated endocytosis retrograde axonal transport endosome membrane postsynaptic density membrane integral component of membrane dentate gyrus development cell junction axon dendrite neuron projection development somatodendritic compartment cell projection synapse postsynaptic membrane positive regulation of neurotrophin TRK receptor signaling pathway postsynaptic density organization dendrite extension modulation of excitatory postsynaptic potential axon cytoplasm cellular response to brain-derived neurotrophic factor stimulus uc009rgy.1 uc009rgy.2 uc009rgy.3 uc009rgy.4 
ENSMUST00000189592.7 Rbmyf5 ENSMUST00000189592.7 RNA binding motif protein Y-linked family member 5 (from RefSeq NM_001270513.1) E9Q856 ENSMUST00000189592.1 ENSMUST00000189592.2 ENSMUST00000189592.3 ENSMUST00000189592.4 ENSMUST00000189592.5 ENSMUST00000189592.6 NM_001270513 O35698 RBY1A_MOUSE Rbm Rbmy1a1 uc029xot.1 uc029xot.2 uc029xot.3 RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. Nucleus Testis-specific. Only expressed in spermatogonia and early spermatocytes, suggesting that expression is inactivated in the XY body during meiosis. The RBMY1 proteins are encoded by repeated regions of the Y chromosome. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. Overexpression of Rbmy proteins in mice carrying the Y(d1) deletion that removes most of the multi-copy Rbmy gene cluster does not have any effect and fails to reduce the frequency of abnormal sperm. These results raize the question of the role of Rbmy proteins in sperm development. male germ cell nucleus hematopoietic progenitor cell differentiation nucleic acid binding RNA binding nucleus spliceosomal complex mRNA processing RNA splicing positive regulation of mRNA splicing, via spliceosome ribonucleoprotein complex uc029xot.1 uc029xot.2 uc029xot.3 
ENSMUST00000189593.2 Prm2 ENSMUST00000189593.2 Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. (from UniProt Q545M0) ENSMUST00000189593.1 Prm2 Q545M0 Q545M0_MOUSE X14004 uc289cjv.1 uc289cjv.2 Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. Interacts with TDRP. Belongs to the protamine P2 family. DNA binding DNA packaging spermatid development uc289cjv.1 uc289cjv.2 
ENSMUST00000189600.2 Gm29166 ENSMUST00000189600.2 Gm29166 (from geneSymbol) ENSMUST00000189600.1 uc292tkw.1 uc292tkw.2 uc292tkw.1 uc292tkw.2 
ENSMUST00000189604.2 Gm28898 ENSMUST00000189604.2 Gm28898 (from geneSymbol) ENSMUST00000189604.1 uc292usn.1 uc292usn.2 uc292usn.1 uc292usn.2 
ENSMUST00000189607.2 Gm28220 ENSMUST00000189607.2 Gm28220 (from geneSymbol) ENSMUST00000189607.1 uc292uws.1 uc292uws.2 uc292uws.1 uc292uws.2 
ENSMUST00000189608.2 Gm28180 ENSMUST00000189608.2 Gm28180 (from geneSymbol) ENSMUST00000189608.1 uc288ads.1 uc288ads.2 uc288ads.1 uc288ads.2 
ENSMUST00000189609.7 Gm29122 ENSMUST00000189609.7 Gm29122 (from geneSymbol) ENSMUST00000189609.1 ENSMUST00000189609.2 ENSMUST00000189609.3 ENSMUST00000189609.4 ENSMUST00000189609.5 ENSMUST00000189609.6 uc292sun.1 uc292sun.2 uc292sun.1 uc292sun.2 
ENSMUST00000189622.2 ENSMUSG00000121840 ENSMUST00000189622.2 ENSMUSG00000121840 (from geneSymbol) ENSMUST00000189622.1 uc287mwe.1 uc287mwe.2 uc287mwe.1 uc287mwe.2 
ENSMUST00000189623.7 Gm29409 ENSMUST00000189623.7 Gm29409 (from geneSymbol) ENSMUST00000189623.1 ENSMUST00000189623.2 ENSMUST00000189623.3 ENSMUST00000189623.4 ENSMUST00000189623.5 ENSMUST00000189623.6 uc292ufz.1 uc292ufz.2 uc292ufz.1 uc292ufz.2 
ENSMUST00000189627.2 Gm28613 ENSMUST00000189627.2 Gm28613 (from geneSymbol) ENSMUST00000189627.1 uc292udh.1 uc292udh.2 uc292udh.1 uc292udh.2 
ENSMUST00000189629.5 Gm42715 ENSMUST00000189629.5 Nucleus (from UniProt A0A087WP63) A0A087WP63 A0A087WP63_MOUSE AK081765 ENSMUST00000189629.1 ENSMUST00000189629.2 ENSMUST00000189629.3 ENSMUST00000189629.4 Gm42715 uc009jvz.1 uc009jvz.2 uc009jvz.3 uc009jvz.4 uc009jvz.5 Nucleus Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. Swr1 complex DNA binding ATP binding chromatin remodeling gene silencing ATPase activity histone binding ATP-dependent chromatin remodeling histone exchange uc009jvz.1 uc009jvz.2 uc009jvz.3 uc009jvz.4 uc009jvz.5 
ENSMUST00000189630.2 Gm21310 ENSMUST00000189630.2 Belongs to the SPIN/STSY family. (from UniProt J3QQ23) ENSMUST00000189630.1 Gm21310 J3QQ23 J3QQ23_MOUSE uc292sev.1 uc292sev.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sev.1 uc292sev.2 
ENSMUST00000189632.2 Gm28732 ENSMUST00000189632.2 Gm28732 (from geneSymbol) ENSMUST00000189632.1 uc292tpg.1 uc292tpg.2 uc292tpg.1 uc292tpg.2 
ENSMUST00000189634.7 Sprr2g ENSMUST00000189634.7 Sprr2g (from geneSymbol) ENSMUST00000189634.1 ENSMUST00000189634.2 ENSMUST00000189634.3 ENSMUST00000189634.4 ENSMUST00000189634.5 ENSMUST00000189634.6 NR_190752 uc008qdv.1 uc008qdv.2 uc008qdv.3 uc008qdv.1 uc008qdv.2 uc008qdv.3 
ENSMUST00000189645.7 Gm28692 ENSMUST00000189645.7 Gm28692 (from geneSymbol) ENSMUST00000189645.1 ENSMUST00000189645.2 ENSMUST00000189645.3 ENSMUST00000189645.4 ENSMUST00000189645.5 ENSMUST00000189645.6 uc292twb.1 uc292twb.2 uc292twb.1 uc292twb.2 
ENSMUST00000189657.2 Gm29450 ENSMUST00000189657.2 Gm29450 (from geneSymbol) ENSMUST00000189657.1 uc292uey.1 uc292uey.2 uc292uey.1 uc292uey.2 
ENSMUST00000189661.7 Soat1 ENSMUST00000189661.7 sterol O-acyltransferase 1 (from RefSeq NM_009230.3) Acact ENSMUST00000189661.1 ENSMUST00000189661.2 ENSMUST00000189661.3 ENSMUST00000189661.4 ENSMUST00000189661.5 ENSMUST00000189661.6 NM_009230 Q5XK32 Q61263 Q64180 SOAT1_MOUSE Soat1 uc007dcj.1 uc007dcj.2 uc007dcj.3 Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions. Reaction=a long-chain fatty acyl-CoA + a sterol = a sterol ester + CoA; Xref=Rhea:RHEA:59816, ChEBI:CHEBI:15889, ChEBI:CHEBI:35915, ChEBI:CHEBI:57287, ChEBI:CHEBI:83139; EC=2.3.1.26; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59817; Evidence=; Reaction=an acyl-CoA + cholesterol = a cholesterol ester + CoA; Xref=Rhea:RHEA:17729, ChEBI:CHEBI:16113, ChEBI:CHEBI:17002, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17730; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + cholesterol = cholesteryl (9Z- octadecenoate) + CoA; Xref=Rhea:RHEA:41436, ChEBI:CHEBI:16113, ChEBI:CHEBI:46898, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41437; Evidence=; Reaction=cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA; Xref=Rhea:RHEA:42792, ChEBI:CHEBI:3663, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42793; Evidence=; Reaction=cholesterol + octadecanoyl-CoA = cholesteryl octadecanoate + CoA; Xref=Rhea:RHEA:42812, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:82750; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42813; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA; Xref=Rhea:RHEA:42796, ChEBI:CHEBI:16113, ChEBI:CHEBI:41509, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42797; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA; Xref=Rhea:RHEA:42816, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:82751; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42817; Evidence=; Reaction=(9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)- hexadecenoate + CoA; Xref=Rhea:RHEA:64320, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:84323; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64321; Evidence=; Reaction=(11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)- octadecenoate + CoA; Xref=Rhea:RHEA:64324, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:75121, ChEBI:CHEBI:88768; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64325; Evidence=; Reaction=(7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)- octadecenoate + CoA; Xref=Rhea:RHEA:64328, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:152049, ChEBI:CHEBI:152050; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64329; Evidence=; May form homo- or heterodimers. Interacts with UBIAD1. Endoplasmic reticulum membrane ; Multi-pass membrane protein Each protomer consists of 9 transmembrane segments, which enclose a cytosolic tunnel and a transmembrane tunnel that converge at the predicted catalytic site: acyl-CoA enters the active site through the cytosolic tunnel, whereas cholesterol enters from the side through the transmembrane tunnel. Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. fatty-acyl-CoA binding sterol O-acyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid metabolic process cholesterol metabolic process O-acyltransferase activity macrophage derived foam cell differentiation cholesterol storage cholesterol binding membrane integral component of membrane transferase activity transferase activity, transferring acyl groups cholesterol efflux very-low-density lipoprotein particle assembly cholesterol esterification cholesterol O-acyltransferase activity cholesterol homeostasis positive regulation of amyloid precursor protein biosynthetic process uc007dcj.1 uc007dcj.2 uc007dcj.3 
ENSMUST00000189669.7 Gm29467 ENSMUST00000189669.7 Gm29467 (from geneSymbol) ENSMUST00000189669.1 ENSMUST00000189669.2 ENSMUST00000189669.3 ENSMUST00000189669.4 ENSMUST00000189669.5 ENSMUST00000189669.6 uc292tui.1 uc292tui.2 uc292tui.1 uc292tui.2 
ENSMUST00000189672.7 Gm10778 ENSMUST00000189672.7 predicted gene 10778 (from RefSeq NM_001142963.1) A0A087WNP5 A0A087WNP5_MOUSE ENSMUST00000189672.1 ENSMUST00000189672.2 ENSMUST00000189672.3 ENSMUST00000189672.4 ENSMUST00000189672.5 ENSMUST00000189672.6 Gm10778 Gm4767 NM_001142963 uc007gje.1 uc007gje.2 uc007gje.3 May be involved in transcriptional regulation. molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc007gje.1 uc007gje.2 uc007gje.3 
ENSMUST00000189682.2 Gm28986 ENSMUST00000189682.2 Gm28986 (from geneSymbol) ENSMUST00000189682.1 uc292sva.1 uc292sva.2 uc292sva.1 uc292sva.2 
ENSMUST00000189686.7 Gm28816 ENSMUST00000189686.7 Gm28816 (from geneSymbol) ENSMUST00000189686.1 ENSMUST00000189686.2 ENSMUST00000189686.3 ENSMUST00000189686.4 ENSMUST00000189686.5 ENSMUST00000189686.6 uc292uqu.1 uc292uqu.2 uc292uqu.1 uc292uqu.2 
ENSMUST00000189689.2 Gm29342 ENSMUST00000189689.2 Gm29342 (from geneSymbol) ENSMUST00000189689.1 uc292txd.1 uc292txd.2 uc292txd.1 uc292txd.2 
ENSMUST00000189701.2 Gm29278 ENSMUST00000189701.2 Gm29278 (from geneSymbol) ENSMUST00000189701.1 uc292uob.1 uc292uob.2 uc292uob.1 uc292uob.2 
ENSMUST00000189704.2 Nscme3l ENSMUST00000189704.2 NSE3 homolog, SMC5-SMC6 complex component like (from RefSeq NM_023781.5) 1700020D05Rik ENSMUST00000189704.1 NM_023781 Nscme3l Q99PB1 Q99PB1_MOUSE uc008gdt.1 uc008gdt.2 uc008gdt.3 uc008gdt.4 molecular_function cellular_component biological_process uc008gdt.1 uc008gdt.2 uc008gdt.3 uc008gdt.4 
ENSMUST00000189711.7 Cfap77 ENSMUST00000189711.7 Cfap77 (from geneSymbol) 1700101E01Rik A0A087WRI3 A0A087WRI3_MOUSE BC147760 Cfap77 ENSMUST00000189711.1 ENSMUST00000189711.2 ENSMUST00000189711.3 ENSMUST00000189711.4 ENSMUST00000189711.5 ENSMUST00000189711.6 uc289ulv.1 uc289ulv.2 molecular_function cellular_component biological_process uc289ulv.1 uc289ulv.2 
ENSMUST00000189716.2 Gm29424 ENSMUST00000189716.2 Belongs to the SPIN/STSY family. (from UniProt A0A9L6KDI9) A0A9L6KDI9 A0A9L6KDI9_MOUSE ENSMUST00000189716.1 Gm29424 uc292uht.1 uc292uht.2 Belongs to the SPIN/STSY family. uc292uht.1 uc292uht.2 
ENSMUST00000189721.2 Gm29311 ENSMUST00000189721.2 Gm29311 (from geneSymbol) ENSMUST00000189721.1 uc292upg.1 uc292upg.2 uc292upg.1 uc292upg.2 
ENSMUST00000189723.7 Gm21064 ENSMUST00000189723.7 predicted gene, 21064 (from RefSeq NR_164186.1) ENSMUST00000189723.1 ENSMUST00000189723.2 ENSMUST00000189723.3 ENSMUST00000189723.4 ENSMUST00000189723.5 ENSMUST00000189723.6 NR_164186 uc029xpk.1 uc029xpk.2 uc029xpk.3 uc029xpk.1 uc029xpk.2 uc029xpk.3 
ENSMUST00000189724.8 ENSMUSG00000121873 ENSMUST00000189724.8 ENSMUSG00000121873 (from geneSymbol) BC099572 ENSMUST00000189724.1 ENSMUST00000189724.2 ENSMUST00000189724.3 ENSMUST00000189724.4 ENSMUST00000189724.5 ENSMUST00000189724.6 ENSMUST00000189724.7 uc007xmj.1 uc007xmj.2 uc007xmj.3 uc007xmj.4 uc007xmj.1 uc007xmj.2 uc007xmj.3 uc007xmj.4 
ENSMUST00000189744.3 D7Ertd128e ENSMUST00000189744.3 D7Ertd128e (from geneSymbol) ENSMUST00000189744.1 ENSMUST00000189744.2 uc291obh.1 uc291obh.2 uc291obh.3 uc291obh.1 uc291obh.2 uc291obh.3 
ENSMUST00000189748.2 1700010H22Rik ENSMUST00000189748.2 1700010H22Rik (from geneSymbol) AK005827 ENSMUST00000189748.1 uc290xji.1 uc290xji.2 uc290xji.1 uc290xji.2 
ENSMUST00000189749.7 Dnah7c ENSMUST00000189749.7 dynein, axonemal, heavy chain 7C (from RefSeq NM_001310335.1) A0A087WR13 A0A087WR13_MOUSE Dnah7c ENSMUST00000189749.1 ENSMUST00000189749.2 ENSMUST00000189749.3 ENSMUST00000189749.4 ENSMUST00000189749.5 ENSMUST00000189749.6 NM_001310335 uc007axb.1 uc007axb.2 uc007axb.3 uc007axb.4 Belongs to the dynein heavy chain family. cilium movement microtubule motor activity calcium ion binding ATP binding cytosol microtubule-based movement ATP-dependent microtubule motor activity, minus-end-directed dynein complex inner dynein arm dynein intermediate chain binding dynein light intermediate chain binding uc007axb.1 uc007axb.2 uc007axb.3 uc007axb.4 
ENSMUST00000189751.2 Gm21626 ENSMUST00000189751.2 Gm21626 (from geneSymbol) ENSMUST00000189751.1 FJ386436 uc292szp.1 uc292szp.2 uc292szp.1 uc292szp.2 
ENSMUST00000189752.7 Gm28765 ENSMUST00000189752.7 Gm28765 (from geneSymbol) ENSMUST00000189752.1 ENSMUST00000189752.2 ENSMUST00000189752.3 ENSMUST00000189752.4 ENSMUST00000189752.5 ENSMUST00000189752.6 uc292sys.1 uc292sys.2 uc292sys.1 uc292sys.2 
ENSMUST00000189753.7 Sh2d1a ENSMUST00000189753.7 Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (from UniProt Q544F1) AF072903 ENSMUST00000189753.1 ENSMUST00000189753.2 ENSMUST00000189753.3 ENSMUST00000189753.4 ENSMUST00000189753.5 ENSMUST00000189753.6 Q544F1 Q544F1_MOUSE Sh2d1a uc292nyh.1 uc292nyh.2 Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Cytoplasm adaptive immune response immune system process SH3/SH2 adaptor activity cytoplasm cellular defense response cell-cell signaling positive regulation of signal transduction innate immune response uc292nyh.1 uc292nyh.2 
ENSMUST00000189759.7 Rd3l ENSMUST00000189759.7 Rd3l (from geneSymbol) B2RV38 B2RV38_MOUSE BC048943 BC048943 ENSMUST00000189759.1 ENSMUST00000189759.2 ENSMUST00000189759.3 ENSMUST00000189759.4 ENSMUST00000189759.5 ENSMUST00000189759.6 Rd3l uc007peg.1 uc007peg.2 uc007peg.3 uc007peg.4 molecular_function cellular_component biological_process uc007peg.1 uc007peg.2 uc007peg.3 uc007peg.4 
ENSMUST00000189765.2 Gm20792 ENSMUST00000189765.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRF5) 1700040F15Rik A0A087WRF5 A0A087WRF5_MOUSE AK077064 ENSMUST00000189765.1 Gm20792 Gm20837 Gm20838 Gm21094 Gm21256 Gm21739 Gm21861 Gm28891 uc292tkz.1 uc292tkz.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc292tkz.1 uc292tkz.2 
ENSMUST00000189772.2 Gm28635 ENSMUST00000189772.2 Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. (from UniProt P30999) BC054544 CTND1_MOUSE Catns Ctnnd1 ENSMUST00000189772.1 Kiaa0384 P30999 Q3TSU9 Q80XQ4 Q8CHF8 uc289xlo.1 uc289xlo.2 Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin/CDH1, alpha-catenin/CTNNA1, beta-catenin/CTNNB1, and gamma-catenin/JUP. Binds to the C-terminal fragment of PSEN1 and mutually competes for CDH1 (By similarity). Interacts with ZBTB33 (PubMed:10207085, PubMed:12087177). Interacts with GLIS2 (PubMed:17344476). Interacts with FER (By similarity). Interacts with NANOS1 (via N-terminal region) (By similarity). Interacts (via N- terminus) with GNA12; the interaction regulates CDH1-mediated cell-cell adhesion (PubMed:15240885). Interacts with GNA13 (PubMed:15240885). Component of a cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1 (By similarity). Interacts with CCDC85B (By similarity). Interacts with PLPP3; negatively regulates the PLPP3-mediated stabilization of CTNNB1 (By similarity). P30999; Q60598: Cttn; NbExp=4; IntAct=EBI-529924, EBI-397955; P30999; P35235: Ptpn11; NbExp=3; IntAct=EBI-529924, EBI-397236; P30999; Q8BN78: Zbtb33; NbExp=3; IntAct=EBI-529924, EBI-1216314; Cell junction, adherens junction Cytoplasm cleus ll membrane Note=Interaction with GLIS2 promotes nuclear translocation (PubMed:17344476). Detected at cell-cell contacts (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (By similarity). CDH1 enhances cell membrane localization (By similarity). [Isoform 2]: Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P30999-1; Sequence=Displayed; Name=2; IsoId=P30999-2; Sequence=VSP_030567, VSP_030568; Name=3; IsoId=P30999-3; Sequence=VSP_030568; Expressed in basal keratinocytes (at protein level). Expressed at the outer limiting membrane of the retina at 18.5 dpc. ARM repeats 1 to 5 mediate interaction with cadherins. Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ (By similarity). Belongs to the beta-catenin family. Sequence=BAC41421.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; morphogenesis of a polarized epithelium kidney development receptor binding protein binding nucleus cytoplasm cytosol plasma membrane cell-cell junction cell-cell adherens junction zonula adherens bicellular tight junction cell-cell junction assembly cell adhesion salivary gland morphogenesis positive regulation of protein processing membrane Wnt signaling pathway catenin complex flotillin complex protein kinase binding protein phosphatase binding protein domain specific binding lamellipodium growth cone midbody dendritic spine synapse cadherin binding cell adhesion molecule binding epithelial cell differentiation involved in salivary gland development glomerulus morphogenesis negative regulation of canonical Wnt signaling pathway cell-cell adhesion presynaptic active zone cytoplasmic component glutamatergic synapse regulation of postsynaptic specialization membrane neurotransmitter receptor levels postsynaptic density, intracellular component positive regulation of peptidyl-tyrosine autophosphorylation uc289xlo.1 uc289xlo.2 
ENSMUST00000189774.2 Krtap14 ENSMUST00000189774.2 keratin associated protein 14 (from RefSeq NM_013707.2) ENSMUST00000189774.1 KRA14_MOUSE Krtap14 NM_013707 O08640 O35148 Pmg1 uc007zvf.1 uc007zvf.2 uc007zvf.3 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Expressed at high levels in skin where it is found predominantly in the keratogenous zone of hair follicle cortical cells and at lower levels in the epithelium of the developing mammary gland. In the developing mammary gland, expression is barely detected in the immature gland at 3 weeks after birth but is evident at the onset of puberty at 3.5 weeks. Expression is high at 4 weeks, declines at 4.5 weeks and is undetectable at 5 weeks. No expression is detected in the mature mammary gland during estrus, pregnancy, lactation or involution. In skin, expression starts shortly after birth and reaches a first maximum at 9 days. A second peak of expression is observed at 3.5 weeks, then levels decline and remain low in the adult. During the hair growth cycle, detected in mid- and late- anagen stages but not in catagen, telogen or early anagen phases. Belongs to the PMG family. Sequence=AAB72042.1; Type=Frameshift; Evidence=; Sequence=AAD47278.1; Type=Frameshift; Evidence=; intermediate filament uc007zvf.1 uc007zvf.2 uc007zvf.3 
ENSMUST00000189778.2 Gm28701 ENSMUST00000189778.2 Gm28701 (from geneSymbol) ENSMUST00000189778.1 uc292upn.1 uc292upn.2 uc292upn.1 uc292upn.2 
ENSMUST00000189780.7 Gm28202 ENSMUST00000189780.7 Gm28202 (from geneSymbol) ENSMUST00000189780.1 ENSMUST00000189780.2 ENSMUST00000189780.3 ENSMUST00000189780.4 ENSMUST00000189780.5 ENSMUST00000189780.6 uc292tsj.1 uc292tsj.2 uc292tsj.1 uc292tsj.2 
ENSMUST00000189781.3 Gm28502 ENSMUST00000189781.3 Gm28502 (from geneSymbol) ENSMUST00000189781.1 ENSMUST00000189781.2 uc288ysn.1 uc288ysn.2 uc288ysn.3 uc288ysn.1 uc288ysn.2 uc288ysn.3 
ENSMUST00000189788.2 Ldhal6b ENSMUST00000189788.2 lactate dehydrogenase A-like 6B (from RefSeq NM_175349.2) ENSMUST00000189788.1 Ldhal6b NM_175349 Q8BVP2 Q8BVP2_MOUSE uc008afb.1 uc008afb.2 Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate; Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27; Evidence=; Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. Belongs to the LDH/MDH superfamily. LDH family. molecular_function catalytic activity L-lactate dehydrogenase activity cytoplasm mitochondrion carbohydrate metabolic process biological_process oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor carboxylic acid metabolic process oxidation-reduction process uc008afb.1 uc008afb.2 
ENSMUST00000189792.2 Gm29323 ENSMUST00000189792.2 Gm29323 (from geneSymbol) ENSMUST00000189792.1 uc287pys.1 uc287pys.2 uc287pys.1 uc287pys.2 
ENSMUST00000189799.7 Dph5 ENSMUST00000189799.7 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. (from UniProt Q9CWQ0) BC060372 DPH5_MOUSE ENSMUST00000189799.1 ENSMUST00000189799.2 ENSMUST00000189799.3 ENSMUST00000189799.4 ENSMUST00000189799.5 ENSMUST00000189799.6 Q6PAC5 Q9CWQ0 uc290ixy.1 uc290ixy.2 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. Reaction=2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:42652, Rhea:RHEA-COMP:9749, Rhea:RHEA- COMP:10173, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73995, ChEBI:CHEBI:79005; EC=2.1.1.314; Evidence=; Protein modification; peptidyl-diphthamide biosynthesis. The protein is expressed in embryos at 18.5 dpc. Belongs to the diphthine synthase family. diphthine synthase activity cellular_component methyltransferase activity transferase activity peptidyl-diphthamide biosynthetic process from peptidyl-histidine methylation uc290ixy.1 uc290ixy.2 
ENSMUST00000189800.7 ENSMUSG00000121328 ENSMUST00000189800.7 ENSMUSG00000121328 (from geneSymbol) ENSMUST00000189800.1 ENSMUST00000189800.2 ENSMUST00000189800.3 ENSMUST00000189800.4 ENSMUST00000189800.5 ENSMUST00000189800.6 uc292ubj.1 uc292ubj.2 uc292ubj.1 uc292ubj.2 
ENSMUST00000189808.7 Gstp3 ENSMUST00000189808.7 glutathione S-transferase pi 3, transcript variant 1 (from RefSeq NM_144869.4) BC021614 ENSMUST00000189808.1 ENSMUST00000189808.2 ENSMUST00000189808.3 ENSMUST00000189808.4 ENSMUST00000189808.5 ENSMUST00000189808.6 Gstp3 NM_144869 Q8VC73 Q8VC73_MOUSE uc008fyh.1 uc008fyh.2 uc008fyh.3 uc008fyh.4 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Homodimer. Belongs to the GST superfamily. Pi family. glutathione transferase activity cytosol glutathione metabolic process uc008fyh.1 uc008fyh.2 uc008fyh.3 uc008fyh.4 
ENSMUST00000189823.2 Gm28515 ENSMUST00000189823.2 Gm28515 (from geneSymbol) AK136272 ENSMUST00000189823.1 uc292cao.1 uc292cao.2 uc292cao.1 uc292cao.2 
ENSMUST00000189825.2 Gm10482 ENSMUST00000189825.2 predicted gene 10482, transcript variant 1 (from RefSeq NR_188760.1) ENSMUST00000189825.1 NR_188760 uc008wlm.1 uc008wlm.2 uc008wlm.3 uc008wlm.1 uc008wlm.2 uc008wlm.3 
ENSMUST00000189842.2 Gm28622 ENSMUST00000189842.2 Gm28622 (from geneSymbol) ENSMUST00000189842.1 uc292its.1 uc292its.2 uc292its.1 uc292its.2 
ENSMUST00000189849.7 Cys1 ENSMUST00000189849.7 cystin 1, transcript variant 1 (from RefSeq NM_138686.3) A0A0R4J216 A0A0R4J216_MOUSE Cys1 ENSMUST00000189849.1 ENSMUST00000189849.2 ENSMUST00000189849.3 ENSMUST00000189849.4 ENSMUST00000189849.5 ENSMUST00000189849.6 NM_138686 uc288fna.1 uc288fna.2 uc288fna.1 uc288fna.2 
ENSMUST00000189853.2 Gm28153 ENSMUST00000189853.2 Gm28153 (from geneSymbol) ENSMUST00000189853.1 uc287gsg.1 uc287gsg.2 uc287gsg.1 uc287gsg.2 
ENSMUST00000189857.2 Gm28586 ENSMUST00000189857.2 Gm28586 (from geneSymbol) ENSMUST00000189857.1 LF197764 uc292jzx.1 uc292jzx.2 uc292jzx.1 uc292jzx.2 
ENSMUST00000189860.2 Gm29477 ENSMUST00000189860.2 Gm29477 (from geneSymbol) ENSMUST00000189860.1 uc288bor.1 uc288bor.2 uc288bor.1 uc288bor.2 
ENSMUST00000189866.2 4930517N10Rik ENSMUST00000189866.2 4930517N10Rik (from geneSymbol) AK015817 ENSMUST00000189866.1 uc009rke.1 uc009rke.2 uc009rke.3 uc009rke.1 uc009rke.2 uc009rke.3 
ENSMUST00000189867.2 9330175M20Rik ENSMUST00000189867.2 RIKEN cDNA 9330175M20 gene (from RefSeq NR_045151.2) ENSMUST00000189867.1 NR_045151 uc029qog.1 uc029qog.2 uc029qog.1 uc029qog.2 
ENSMUST00000189869.2 Gm29252 ENSMUST00000189869.2 Gm29252 (from geneSymbol) ENSMUST00000189869.1 uc292tpy.1 uc292tpy.2 uc292tpy.1 uc292tpy.2 
ENSMUST00000189888.7 Zfy1 ENSMUST00000189888.7 Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity). (from UniProt P10925) AK076618 E9QKM5 ENSMUST00000189888.1 ENSMUST00000189888.2 ENSMUST00000189888.3 ENSMUST00000189888.4 ENSMUST00000189888.5 ENSMUST00000189888.6 P10925 Q8C638 ZFY1_MOUSE Zfy-1 uc292rvi.1 uc292rvi.2 Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity). Nucleus. The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13. Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc292rvi.1 uc292rvi.2 
ENSMUST00000189897.2 Myrf ENSMUST00000189897.2 myelin regulatory factor, transcript variant 2 (from RefSeq NM_001404113.1) B2RXQ7 ENSMUST00000189897.1 F8WJJ9 Gm1804 Gm98 MYRF_MOUSE Mrf NM_001404113 Q3UR85 Q3V3K4 uc012bil.1 uc012bil.2 uc012bil.3 [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. [Myelin regulatory factor, C-terminal]: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage. [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:19596243, PubMed:22956843, PubMed:23966833, PubMed:24204311, PubMed:27532821). Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:19596243, PubMed:22956843, PubMed:23966833). Homotrimer (PubMed:23966833, PubMed:28623291). Interacts (via C-terminal region) with TMEM98; the interaction inhibits MYRF self- cleavage (PubMed:30249802). [Myelin regulatory factor]: Endoplasmic reticulum membrane ; Single-pass membrane protein. [Myelin regulatory factor, N-terminal]: Nucleus toplasm Note=Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage. [Myelin regulatory factor, C-terminal]: Endoplasmic reticulum membrane ingle-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3UR85-1; Sequence=Displayed; Name=2; IsoId=Q3UR85-2; Sequence=VSP_031303, VSP_031304; Name=3; IsoId=Q3UR85-3; Sequence=VSP_053374; Name=4; IsoId=Q3UR85-5; Sequence=VSP_053992, VSP_053993; Specifically expressed by postmitotic oligodendrocytes in the CNS. Not detected in the peripheral nervous system (PNS). At postnatal day 3 (P3), the expression is restricted to cells in the hindbrain and cerebellum, subsequently spreading rostrally throughout the white matter tracks over the first 2 weeks postnatal, mirroring the expression of Plp1. Expression is directly regulated by SOX10. [Myelin regulatory factor, N-terminal]: The nuclear localization signals mediate translocation to the nucleus. [Myelin regulatory factor]: The peptidase S74 domain, also named Intramolecular Chaperone Auto-processed (ICA) domain or Intramolecular Chaperone Domain (ICD), has protease activity and mediates autocatalytic processing of the protein to generate the Myelin regulatory factor, N-terminal active transcription factor and the Myelin regulatory factor, C-terminal components. [Myelin regulatory factor, C-terminal]: Glycosylated. [Myelin regulatory factor]: Follows autocatalytic cleavage via the peptidase S74 domain. Autoprocessing is apparently constitutive and is essential for transcriptional activity (PubMed:23966833, PubMed:28623291, PubMed:30249802). Autocatalytic cleavage is inhibited by interaction with TMEM98 (PubMed:30249802). Embryos die around 12.5 dpc. Conditional knockout mice in which Mrf is lacking within the oligodendrocyte lineage display severe deficits in myelin gene expression and premyelinating oligodendrocytes fail to myelinate. These mice display severe neurological abnormalities and die because of seizures during the third postnatal week. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Dubious isoform due to intron retention. Belongs to the MRF family. DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol regulation of transcription, DNA-templated proteolysis peptidase activity oligodendrocyte development membrane integral component of membrane protein autoprocessing hydrolase activity central nervous system myelination cell differentiation positive regulation of myelination central nervous system myelin maintenance identical protein binding sequence-specific DNA binding positive regulation of transcription, DNA-templated oligodendrocyte differentiation uc012bil.1 uc012bil.2 uc012bil.3 
ENSMUST00000189898.2 Gm29587 ENSMUST00000189898.2 Gm29587 (from geneSymbol) ENSMUST00000189898.1 uc288hfe.1 uc288hfe.2 uc288hfe.1 uc288hfe.2 
ENSMUST00000189899.2 Gm29040 ENSMUST00000189899.2 Gm29040 (from geneSymbol) AK144903 ENSMUST00000189899.1 uc287hsa.1 uc287hsa.2 uc287hsa.1 uc287hsa.2 
ENSMUST00000189901.2 Gm28132 ENSMUST00000189901.2 Gm28132 (from geneSymbol) ENSMUST00000189901.1 uc292svi.1 uc292svi.2 uc292svi.1 uc292svi.2 
ENSMUST00000189921.2 Gm29580 ENSMUST00000189921.2 Gm29580 (from geneSymbol) ENSMUST00000189921.1 uc292swa.1 uc292swa.2 uc292swa.1 uc292swa.2 
ENSMUST00000189924.2 Gm29110 ENSMUST00000189924.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WP44) A0A087WP44 A0A087WP44_MOUSE ENSMUST00000189924.1 Gm21760 Gm28827 Gm28897 Gm29110 Gm29564 Gm31571 uc292unj.1 uc292unj.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292unj.1 uc292unj.2 
ENSMUST00000189929.2 2810407A14Rik ENSMUST00000189929.2 2810407A14Rik (from geneSymbol) AK153724 ENSMUST00000189929.1 uc289fva.1 uc289fva.2 uc289fva.1 uc289fva.2 
ENSMUST00000189936.7 Uchl5 ENSMUST00000189936.7 ubiquitin carboxyl-terminal esterase L5, transcript variant 1 (from RefSeq NM_019562.2) ENSMUST00000189936.1 ENSMUST00000189936.2 ENSMUST00000189936.3 ENSMUST00000189936.4 ENSMUST00000189936.5 ENSMUST00000189936.6 NM_019562 Q9CVJ4 Q9CXZ3 Q9R107 Q9WUP7 UCHL5_MOUSE Uch37 uc007cxe.1 uc007cxe.2 uc007cxe.3 uc007cxe.4 Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Activated by ADRM1. Inhibited by interaction with NFRKB (By similarity). Component of the 19S (PA700) regulatory complex of the 26S proteasome. Interacts with ADRM1 and NFRKB. Component of the INO80 complex; specifically part of a complex module associated with N- terminus of INO80 (By similarity). Cytoplasm Nucleus Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WUP7-1; Sequence=Displayed; Name=2; IsoId=Q9WUP7-2; Sequence=VSP_005255; Belongs to the peptidase C12 family. proteasome complex thiol-dependent ubiquitin-specific protease activity endopeptidase inhibitor activity nucleus nucleoplasm cytoplasm mitochondrion cytosol DNA repair DNA recombination proteolysis ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus peptidase activity cysteine-type peptidase activity negative regulation of endopeptidase activity protein deubiquitination hydrolase activity lateral ventricle development midbrain development Ino80 complex cytosolic proteasome complex negative regulation of proteasomal ubiquitin-dependent protein catabolic process thiol-dependent ubiquitinyl hydrolase activity forebrain morphogenesis regulation of proteasomal protein catabolic process proteasome binding uc007cxe.1 uc007cxe.2 uc007cxe.3 uc007cxe.4 
ENSMUST00000189939.2 Gm28744 ENSMUST00000189939.2 Gm28744 (from geneSymbol) ENSMUST00000189939.1 uc291rji.1 uc291rji.2 uc291rji.1 uc291rji.2 
ENSMUST00000189942.2 2810454H06Rik ENSMUST00000189942.2 RIKEN cDNA 2810454H06 gene (from RefSeq NR_029441.1) ENSMUST00000189942.1 NR_029441 uc012eup.1 uc012eup.2 uc012eup.3 uc012eup.1 uc012eup.2 uc012eup.3 
ENSMUST00000189943.7 Gm29271 ENSMUST00000189943.7 Gm29271 (from geneSymbol) ENSMUST00000189943.1 ENSMUST00000189943.2 ENSMUST00000189943.3 ENSMUST00000189943.4 ENSMUST00000189943.5 ENSMUST00000189943.6 uc292tlv.1 uc292tlv.2 uc292tlv.1 uc292tlv.2 
ENSMUST00000189947.2 Gm29445 ENSMUST00000189947.2 Gm29445 (from geneSymbol) ENSMUST00000189947.1 uc292tiu.1 uc292tiu.2 uc292tiu.1 uc292tiu.2 
ENSMUST00000189948.2 Gm28315 ENSMUST00000189948.2 Gm28315 (from geneSymbol) ENSMUST00000189948.1 uc292tnt.1 uc292tnt.2 uc292tnt.1 uc292tnt.2 
ENSMUST00000189953.2 Gm29168 ENSMUST00000189953.2 Gm29168 (from geneSymbol) ENSMUST00000189953.1 uc289nhr.1 uc289nhr.2 uc289nhr.1 uc289nhr.2 
ENSMUST00000189963.2 Gm29116 ENSMUST00000189963.2 Gm29116 (from geneSymbol) ENSMUST00000189963.1 uc292tna.1 uc292tna.2 uc292tna.1 uc292tna.2 
ENSMUST00000189979.2 Gm28109 ENSMUST00000189979.2 Gm28109 (from geneSymbol) ENSMUST00000189979.1 uc292uyc.1 uc292uyc.2 uc292uyc.1 uc292uyc.2 
ENSMUST00000189989.2 Gm28201 ENSMUST00000189989.2 Gm28201 (from geneSymbol) ENSMUST00000189989.1 uc292tsi.1 uc292tsi.2 uc292tsi.1 uc292tsi.2 
ENSMUST00000189996.2 Gm29439 ENSMUST00000189996.2 Gm29439 (from geneSymbol) ENSMUST00000189996.1 uc291oaz.1 uc291oaz.2 uc291oaz.1 uc291oaz.2 
ENSMUST00000190004.2 Gm29295 ENSMUST00000190004.2 Gm29295 (from geneSymbol) ENSMUST00000190004.1 uc291rin.1 uc291rin.2 uc291rin.1 uc291rin.2 
ENSMUST00000190006.2 Gm28826 ENSMUST00000190006.2 Gm28826 (from geneSymbol) ENSMUST00000190006.1 uc287hxb.1 uc287hxb.2 uc287hxb.1 uc287hxb.2 
ENSMUST00000190010.7 ENSMUSG00000121292 ENSMUST00000190010.7 ENSMUSG00000121292 (from geneSymbol) ENSMUST00000190010.1 ENSMUST00000190010.2 ENSMUST00000190010.3 ENSMUST00000190010.4 ENSMUST00000190010.5 ENSMUST00000190010.6 uc292ulr.1 uc292ulr.2 uc292ulr.1 uc292ulr.2 
ENSMUST00000190011.7 Gm28249 ENSMUST00000190011.7 Gm28249 (from geneSymbol) ENSMUST00000190011.1 ENSMUST00000190011.2 ENSMUST00000190011.3 ENSMUST00000190011.4 ENSMUST00000190011.5 ENSMUST00000190011.6 uc292ssy.1 uc292ssy.2 uc292ssy.1 uc292ssy.2 
ENSMUST00000190017.2 Gm28656 ENSMUST00000190017.2 Gm28656 (from geneSymbol) ENSMUST00000190017.1 uc292sgh.1 uc292sgh.2 uc292sgh.1 uc292sgh.2 
ENSMUST00000190026.2 Gm28919 ENSMUST00000190026.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WP35) A0A087WP35 A0A087WP35_MOUSE ENSMUST00000190026.1 Gm28919 uc292sbb.1 uc292sbb.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292sbb.1 uc292sbb.2 
ENSMUST00000190031.2 Gm28954 ENSMUST00000190031.2 Gm28954 (from geneSymbol) ENSMUST00000190031.1 uc292sfr.1 uc292sfr.2 uc292sfr.1 uc292sfr.2 
ENSMUST00000190040.2 Gm28523 ENSMUST00000190040.2 Gm28523 (from geneSymbol) AK089148 ENSMUST00000190040.1 uc291jzf.1 uc291jzf.2 uc291jzf.1 uc291jzf.2 
ENSMUST00000190044.7 Kcnma1 ENSMUST00000190044.7 potassium large conductance calcium-activated channel, subfamily M, alpha member 1, transcript variant 22 (from RefSeq NM_001253378.1) A0A087WQ41 A0A087WQ41_MOUSE ENSMUST00000190044.1 ENSMUST00000190044.2 ENSMUST00000190044.3 ENSMUST00000190044.4 ENSMUST00000190044.5 ENSMUST00000190044.6 Kcnma1 NM_001253378 uc007smi.1 uc007smi.2 uc007smi.3 uc007smi.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily. ion channel activity ion transport potassium ion transport membrane integral component of membrane ion transmembrane transport transmembrane transport large conductance calcium-activated potassium channel activity potassium ion transmembrane transport uc007smi.1 uc007smi.2 uc007smi.3 uc007smi.4 
ENSMUST00000190050.2 Gm28539 ENSMUST00000190050.2 Belongs to the UPF0545 family. (from UniProt A0A087WSL9) A0A087WSL9 A0A087WSL9_MOUSE BC156807 ENSMUST00000190050.1 Gm28539 uc289dfv.1 uc289dfv.2 Belongs to the UPF0545 family. uc289dfv.1 uc289dfv.2 
ENSMUST00000190053.2 1700036A12Rik ENSMUST00000190053.2 1700036A12Rik (from geneSymbol) AK006609 ENSMUST00000190053.1 uc292hxb.1 uc292hxb.2 uc292hxb.1 uc292hxb.2 
ENSMUST00000190066.7 Zfp995 ENSMUST00000190066.7 zinc finger protein 995 (from RefSeq NM_001256493.1) E9Q6M3 E9Q6M3_MOUSE ENSMUST00000190066.1 ENSMUST00000190066.2 ENSMUST00000190066.3 ENSMUST00000190066.4 ENSMUST00000190066.5 ENSMUST00000190066.6 NM_001256493 Zfp995 uc012alo.1 uc012alo.2 uc012alo.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc012alo.1 uc012alo.2 uc012alo.3 
ENSMUST00000190069.2 Gm28745 ENSMUST00000190069.2 Gm28745 (from geneSymbol) ENSMUST00000190069.1 uc291rjg.1 uc291rjg.2 uc291rjg.1 uc291rjg.2 
ENSMUST00000190080.9 Trerf1 ENSMUST00000190080.9 transcriptional regulating factor 1, transcript variant 1 (from RefSeq NM_001097623.2) ENSMUST00000190080.1 ENSMUST00000190080.2 ENSMUST00000190080.3 ENSMUST00000190080.4 ENSMUST00000190080.5 ENSMUST00000190080.6 ENSMUST00000190080.7 ENSMUST00000190080.8 NM_001097623 Q32NY5 Q6PCQ4 Q80X25 Q810H8 Q8BXJ2 Q8BY31 TREF1_MOUSE uc057kxz.1 uc057kxz.2 uc057kxz.3 Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. Interacts with CREBBP and EP300. Interacts with DNTTIP1 and DNTT. Nucleus Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BXJ2-1; Sequence=Displayed; Name=2; IsoId=Q8BXJ2-2; Sequence=VSP_015650; Name=3; IsoId=Q8BXJ2-3; Sequence=VSP_015647, VSP_015648, VSP_015649; Name=4; IsoId=Q8BXJ2-4; Sequence=VSP_015647, VSP_015651; Highly expressed in kidney, lung and brain. In the brain, expression was seen in the basal ganglia, hippocampus, piriform cortex, cerebral cortex, ventromedial nucleus of the hypothalamus and the dorsal and superior central nuclei of the raphe. At 15.5 dpc, highly expressed in brain, lung, adrenal, thymus and kidney. Expression was also seen in spinal cord, retina and snout. Sequence=AAN02288.1; Type=Frameshift; Evidence=; histone deacetylase complex nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor complex nucleolus cytosol transcription factor binding transcription regulatory region DNA binding positive regulation of transcription, DNA-templated metal ion binding uc057kxz.1 uc057kxz.2 uc057kxz.3 
ENSMUST00000190081.7 Fam78b ENSMUST00000190081.7 family with sequence similarity 78, member B, transcript variant 2 (from RefSeq NM_175461.4) A2RSM0 ENSMUST00000190081.1 ENSMUST00000190081.2 ENSMUST00000190081.3 ENSMUST00000190081.4 ENSMUST00000190081.5 ENSMUST00000190081.6 FA78B_MOUSE NM_175461 Q8BQN5 Q8CC61 uc007dkt.1 uc007dkt.2 uc007dkt.3 Belongs to the FAM78 family. Sequence=BAC28491.1; Type=Erroneous initiation; Evidence=; Sequence=BAC33132.1; Type=Erroneous initiation; Evidence=; Sequence=BAE25775.1; Type=Erroneous initiation; Evidence=; molecular_function cellular_component biological_process uc007dkt.1 uc007dkt.2 uc007dkt.3 
ENSMUST00000190085.2 Gm28189 ENSMUST00000190085.2 Gm28189 (from geneSymbol) ENSMUST00000190085.1 uc287lac.1 uc287lac.2 uc287lac.1 uc287lac.2 
ENSMUST00000190091.7 Smpx ENSMUST00000190091.7 small muscle protein, X-linked, transcript variant 1 (from RefSeq NR_103722.1) A2RT38 Csl ENSMUST00000190091.1 ENSMUST00000190091.2 ENSMUST00000190091.3 ENSMUST00000190091.4 ENSMUST00000190091.5 ENSMUST00000190091.6 NR_103722 Q4QRM9 Q8CEX8 Q9DC77 Q9ER98 SMPX_MOUSE uc292rlg.1 uc292rlg.2 Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. Abundantly expressed in heart and skeletal muscle. Expression is increased by passive stretch. Belongs to the SMPX family. nucleus cytoplasm muscle tendon junction M band costamere contractile fiber uc292rlg.1 uc292rlg.2 
ENSMUST00000190096.7 Agap1 ENSMUST00000190096.7 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1, transcript variant 2 (from RefSeq NM_001037136.1) A0A087WRF2 A0A087WRF2_MOUSE Agap1 ENSMUST00000190096.1 ENSMUST00000190096.2 ENSMUST00000190096.3 ENSMUST00000190096.4 ENSMUST00000190096.5 ENSMUST00000190096.6 NM_001037136 uc007byx.1 uc007byx.2 uc007byx.3 Belongs to the centaurin gamma-like family. GTPase activity GTPase activator activity GTP binding positive regulation of GTPase activity metal ion binding uc007byx.1 uc007byx.2 uc007byx.3 
ENSMUST00000190100.2 Gm28171 ENSMUST00000190100.2 Belongs to the SPIN/STSY family. (from UniProt A0A087WQ19) A0A087WQ19 A0A087WQ19_MOUSE ENSMUST00000190100.1 Gm28171 uc292saf.1 uc292saf.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292saf.1 uc292saf.2 
ENSMUST00000190102.2 Gm29198 ENSMUST00000190102.2 Gm29198 (from geneSymbol) ENSMUST00000190102.1 uc292saq.1 uc292saq.2 uc292saq.1 uc292saq.2 
ENSMUST00000190106.2 ENSMUSG00000121314 ENSMUST00000190106.2 ENSMUSG00000121314 (from geneSymbol) ENSMUST00000190106.1 uc292tty.1 uc292tty.2 uc292tty.1 uc292tty.2 
ENSMUST00000190113.2 Gm29562 ENSMUST00000190113.2 Gm29562 (from geneSymbol) BC054427 ENSMUST00000190113.1 uc292jmg.1 uc292jmg.2 uc292jmg.1 uc292jmg.2 
ENSMUST00000190116.7 Thap4 ENSMUST00000190116.7 THAP domain containing 4, transcript variant 1 (from RefSeq NM_025920.3) ENSMUST00000190116.1 ENSMUST00000190116.2 ENSMUST00000190116.3 ENSMUST00000190116.4 ENSMUST00000190116.5 ENSMUST00000190116.6 NM_025920 Q3US28 Q6NZN6 Q6P3Z3 Q6PEN6 Q91WR2 Q9CVE5 Q9CVG3 THAP4_MOUSE Thap4 uc007cef.1 uc007cef.2 uc007cef.3 Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N- terminal region. Reaction=peroxynitrite = nitrate; Xref=Rhea:RHEA:63116, ChEBI:CHEBI:17632, ChEBI:CHEBI:25941; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63117; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom. ; Nitrogen metabolism. Homodimer. Cytoplasm Nucleus Note=Localizes mainly in the cytoplasm and partially in the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P3Z3-1; Sequence=Displayed; Name=2; IsoId=Q6P3Z3-2; Sequence=VSP_020080, VSP_020081; The C-terminal nitrobindin region coordinates a heme and bears the isomerase activity. The N-terminal zinc finger domain likely binds DNA and may be involved in transcriptional regulation. In the C-terminal section; belongs to the nitrobindin family. nucleic acid binding DNA binding cellular_component biological_process heme binding protein homodimerization activity metal ion binding uc007cef.1 uc007cef.2 uc007cef.3 
ENSMUST00000190117.2 Gm28960 ENSMUST00000190117.2 Gm28960 (from geneSymbol) ENSMUST00000190117.1 uc287mpp.1 uc287mpp.2 uc287mpp.1 uc287mpp.2 
ENSMUST00000190118.2 Gm28231 ENSMUST00000190118.2 Gm28231 (from geneSymbol) AK144951 ENSMUST00000190118.1 uc292jkj.1 uc292jkj.2 uc292jkj.1 uc292jkj.2 
ENSMUST00000190120.2 1700052K11Rik ENSMUST00000190120.2 RIKEN cDNA 1700052K11 gene (from RefSeq NR_027956.1) ENSMUST00000190120.1 NR_027956 uc007lxc.1 uc007lxc.2 uc007lxc.3 uc007lxc.4 uc007lxc.5 uc007lxc.1 uc007lxc.2 uc007lxc.3 uc007lxc.4 uc007lxc.5 
ENSMUST00000190123.3 1700066N21Rik ENSMUST00000190123.3 1700066N21Rik (from geneSymbol) AK006908 ENSMUST00000190123.1 ENSMUST00000190123.2 uc029vja.1 uc029vja.2 uc029vja.3 uc029vja.4 uc029vja.1 uc029vja.2 uc029vja.3 uc029vja.4 
ENSMUST00000190126.7 Gm28519 ENSMUST00000190126.7 Gm28519 (from geneSymbol) ENSMUST00000190126.1 ENSMUST00000190126.2 ENSMUST00000190126.3 ENSMUST00000190126.4 ENSMUST00000190126.5 ENSMUST00000190126.6 uc292szh.1 uc292szh.2 uc292szh.1 uc292szh.2 
ENSMUST00000190129.2 Gm28617 ENSMUST00000190129.2 Gm28617 (from geneSymbol) ENSMUST00000190129.1 uc292tfz.1 uc292tfz.2 uc292tfz.1 uc292tfz.2 
ENSMUST00000190132.2 Gm5441 ENSMUST00000190132.2 predicted gene 5441 (from RefSeq NR_044987.1) ENSMUST00000190132.1 NR_044987 uc029ryo.1 uc029ryo.2 uc029ryo.1 uc029ryo.2 
ENSMUST00000190133.2 Gm28472 ENSMUST00000190133.2 Gm28472 (from geneSymbol) ENSMUST00000190133.1 uc292uuw.1 uc292uuw.2 uc292uuw.1 uc292uuw.2 
ENSMUST00000190140.7 Gm29081 ENSMUST00000190140.7 Gm29081 (from geneSymbol) ENSMUST00000190140.1 ENSMUST00000190140.2 ENSMUST00000190140.3 ENSMUST00000190140.4 ENSMUST00000190140.5 ENSMUST00000190140.6 uc292tao.1 uc292tao.2 uc292tao.1 uc292tao.2 
ENSMUST00000190144.2 Gm28427 ENSMUST00000190144.2 Gm28427 (from geneSymbol) ENSMUST00000190144.1 uc292tgt.1 uc292tgt.2 uc292tgt.1 uc292tgt.2 
ENSMUST00000190145.3 Gm5890 ENSMUST00000190145.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; (from UniProt A0A140LI04) A0A140LI04 A0A140LI04_MOUSE ENSMUST00000190145.1 ENSMUST00000190145.2 Gm5890 uc291mny.1 uc291mny.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. nucleotide binding microtubule cytoskeleton organization protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm protein phosphorylation intracellular signal transduction tau-protein kinase activity uc291mny.1 uc291mny.2 
ENSMUST00000190148.2 Gm28140 ENSMUST00000190148.2 Gm28140 (from geneSymbol) ENSMUST00000190148.1 uc287hqv.1 uc287hqv.2 uc287hqv.1 uc287hqv.2 
ENSMUST00000190161.2 Gm28880 ENSMUST00000190161.2 Gm28880 (from geneSymbol) ENSMUST00000190161.1 uc292stk.1 uc292stk.2 uc292stk.1 uc292stk.2 
ENSMUST00000190168.2 Gm29381 ENSMUST00000190168.2 Gm29381 (from geneSymbol) ENSMUST00000190168.1 uc292ucg.1 uc292ucg.2 uc292ucg.1 uc292ucg.2 
ENSMUST00000190173.2 Gm20814 ENSMUST00000190173.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE ENSMUST00000190173.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292uny.1 uc292uny.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292uny.1 uc292uny.2 
ENSMUST00000190178.7 Gm7073 ENSMUST00000190178.7 predicted gene 7073, transcript variant 2 (from RefSeq NM_001039240.3) E9QAS1 E9QAS1_MOUSE ENSMUST00000190178.1 ENSMUST00000190178.2 ENSMUST00000190178.3 ENSMUST00000190178.4 ENSMUST00000190178.5 ENSMUST00000190178.6 Gm7073 NM_001039240 uc009tid.1 uc009tid.2 molecular_function cellular_component biological_process uc009tid.1 uc009tid.2 
ENSMUST00000190179.2 Gm29341 ENSMUST00000190179.2 Gm29341 (from geneSymbol) ENSMUST00000190179.1 uc288ppp.1 uc288ppp.2 uc288ppp.1 uc288ppp.2 
ENSMUST00000190181.2 Gm29584 ENSMUST00000190181.2 Gm29584 (from geneSymbol) ENSMUST00000190181.1 uc292uan.1 uc292uan.2 uc292uan.1 uc292uan.2 
ENSMUST00000190183.7 Gm28454 ENSMUST00000190183.7 Gm28454 (from geneSymbol) ENSMUST00000190183.1 ENSMUST00000190183.2 ENSMUST00000190183.3 ENSMUST00000190183.4 ENSMUST00000190183.5 ENSMUST00000190183.6 uc292stn.1 uc292stn.2 uc292stn.1 uc292stn.2 
ENSMUST00000190184.2 Gm29051 ENSMUST00000190184.2 Gm29051 (from geneSymbol) ENSMUST00000190184.1 uc289mgz.1 uc289mgz.2 uc289mgz.1 uc289mgz.2 
ENSMUST00000190185.7 ENSMUSG00000121323 ENSMUST00000190185.7 ENSMUSG00000121323 (from geneSymbol) ENSMUST00000190185.1 ENSMUST00000190185.2 ENSMUST00000190185.3 ENSMUST00000190185.4 ENSMUST00000190185.5 ENSMUST00000190185.6 uc292tzc.1 uc292tzc.2 uc292tzc.1 uc292tzc.2 
ENSMUST00000190193.8 Col6a5 ENSMUST00000190193.8 collagen, type VI, alpha 5 (from RefSeq NM_001167923.1) A0A140T8W1 A0A140T8W1_MOUSE Col6a5 ENSMUST00000190193.1 ENSMUST00000190193.2 ENSMUST00000190193.3 ENSMUST00000190193.4 ENSMUST00000190193.5 ENSMUST00000190193.6 ENSMUST00000190193.7 NM_001167923 uc029xfx.1 uc029xfx.2 uc029xfx.3 uc029xfx.1 uc029xfx.2 uc029xfx.3 
ENSMUST00000190194.2 Gm28867 ENSMUST00000190194.2 Gm28867 (from geneSymbol) AK145806 ENSMUST00000190194.1 uc287lbr.1 uc287lbr.2 uc287lbr.1 uc287lbr.2 
ENSMUST00000190196.5 Prob1 ENSMUST00000190196.5 proline rich basic protein 1 (from RefSeq NM_001270646.2) A0A087WR45 A0A087WR45_MOUSE ENSMUST00000190196.1 ENSMUST00000190196.2 ENSMUST00000190196.3 ENSMUST00000190196.4 NM_001270646 Prob1 uc033hgc.1 uc033hgc.2 uc033hgc.3 uc033hgc.4 molecular_function cellular_component biological_process uc033hgc.1 uc033hgc.2 uc033hgc.3 uc033hgc.4 
ENSMUST00000190204.2 2700089I24Rik ENSMUST00000190204.2 RIKEN cDNA 2700089I24 gene (from RefSeq NR_045308.1) ENSMUST00000190204.1 NR_045308 uc029ttc.1 uc029ttc.2 uc029ttc.1 uc029ttc.2 
ENSMUST00000190221.2 Gm28284 ENSMUST00000190221.2 Gm28284 (from geneSymbol) ENSMUST00000190221.1 uc292tur.1 uc292tur.2 uc292tur.1 uc292tur.2 
ENSMUST00000190224.2 Gm29170 ENSMUST00000190224.2 Gm29170 (from geneSymbol) ENSMUST00000190224.1 uc287mil.1 uc287mil.2 uc287mil.1 uc287mil.2 
ENSMUST00000190226.7 Cdv3 ENSMUST00000190226.7 Belongs to the CDV3 family. (from UniProt A0A087WS49) A0A087WS49 A0A087WS49_MOUSE BC031362 Cdv3 ENSMUST00000190226.1 ENSMUST00000190226.2 ENSMUST00000190226.3 ENSMUST00000190226.4 ENSMUST00000190226.5 ENSMUST00000190226.6 uc292kff.1 uc292kff.2 Belongs to the CDV3 family. uc292kff.1 uc292kff.2 
ENSMUST00000190228.2 Gm29670 ENSMUST00000190228.2 Gm29670 (from geneSymbol) AK138105 ENSMUST00000190228.1 uc287ibh.1 uc287ibh.2 uc287ibh.1 uc287ibh.2 
ENSMUST00000190229.7 Pinc ENSMUST00000190229.7 pregnancy induced noncoding RNA (from RefSeq NR_003202.2) ENSMUST00000190229.1 ENSMUST00000190229.2 ENSMUST00000190229.3 ENSMUST00000190229.4 ENSMUST00000190229.5 ENSMUST00000190229.6 NR_003202 uc007blb.1 uc007blb.2 uc007blb.3 uc007blb.1 uc007blb.2 uc007blb.3 
ENSMUST00000190233.2 1700025B11Rik ENSMUST00000190233.2 RIKEN cDNA 1700025B11 gene (from RefSeq NR_040310.1) 1700025B11Rik A0A087WNZ6 A0A087WNZ6_MOUSE ENSMUST00000190233.1 NR_040310 uc007wnt.1 uc007wnt.2 uc007wnt.3 uc007wnt.4 uc007wnt.5 Belongs to the CD225/Dispanin family. membrane integral component of membrane uc007wnt.1 uc007wnt.2 uc007wnt.3 uc007wnt.4 uc007wnt.5 
ENSMUST00000190236.2 Gm29063 ENSMUST00000190236.2 Gm29063 (from geneSymbol) ENSMUST00000190236.1 uc292top.1 uc292top.2 uc292top.1 uc292top.2 
ENSMUST00000190242.2 Gm28404 ENSMUST00000190242.2 Gm28404 (from geneSymbol) BC019626 ENSMUST00000190242.1 uc287kvx.1 uc287kvx.2 uc287kvx.1 uc287kvx.2 
ENSMUST00000190245.7 Neil1 ENSMUST00000190245.7 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5- hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. (from UniProt Q8K4Q6) AK013322 ENSMUST00000190245.1 ENSMUST00000190245.2 ENSMUST00000190245.3 ENSMUST00000190245.4 ENSMUST00000190245.5 ENSMUST00000190245.6 NEIL1_MOUSE Nei1 Q80V58 Q8K4Q6 Q9CYT9 uc009puj.1 uc009puj.2 uc009puj.3 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5- hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA- COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695, ChEBI:CHEBI:167181; EC=4.2.99.18; Evidence= Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Chromosome. Note=During mitosis, associates with centrosomes and condensed chromatin. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K4Q6-1; Sequence=Displayed; Name=2; IsoId=Q8K4Q6-2; Sequence=VSP_012207; Detected in heart, spleen and lung. Up-regulated during S-phase. Belongs to the FPG family. Sequence=BAB28790.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding damaged DNA binding catalytic activity DNA-(apurinic or apyrimidinic site) lyase activity nucleus nucleoplasm chromosome cytoplasm microtubule organizing center cytoskeleton DNA repair base-excision repair nucleotide-excision repair cellular response to DNA damage stimulus response to oxidative stress protein C-terminus binding metabolic process zinc ion binding hydrolase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing N-glycosyl compounds lyase activity DNA N-glycosylase activity negative regulation of nuclease activity uc009puj.1 uc009puj.2 uc009puj.3 
ENSMUST00000190254.3 4930434B07Rik ENSMUST00000190254.3 4930434B07Rik (from geneSymbol) AK015307 ENSMUST00000190254.1 ENSMUST00000190254.2 uc287khp.1 uc287khp.2 uc287khp.3 uc287khp.1 uc287khp.2 uc287khp.3 
ENSMUST00000190256.2 Gm28357 ENSMUST00000190256.2 Gm28357 (from geneSymbol) ENSMUST00000190256.1 uc292rze.1 uc292rze.2 uc292rze.1 uc292rze.2 
ENSMUST00000190257.3 Gm28516 ENSMUST00000190257.3 Gm28516 (from geneSymbol) AK049522 ENSMUST00000190257.1 ENSMUST00000190257.2 uc009msx.1 uc009msx.2 uc009msx.3 uc009msx.1 uc009msx.2 uc009msx.3 
ENSMUST00000190262.2 Ly6g ENSMUST00000190262.2 lymphocyte antigen 6 family member G, transcript variant 2 (from RefSeq NM_001374230.1) A0A087WQF5 ENSMUST00000190262.1 LY6G_MOUSE NM_001374230 P35461 uc057bgk.1 uc057bgk.2 uc057bgk.3 Cell membrane ; Lipid-anchor, GPI- anchor Expressed in bone marrow. plasma membrane external side of plasma membrane membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway negative regulation of receptor activity uc057bgk.1 uc057bgk.2 uc057bgk.3 
ENSMUST00000190264.3 Alyreffm9 ENSMUST00000190264.3 predicted gene 4312 (from RefSeq NM_001166636.1) ENSMUST00000190264.1 ENSMUST00000190264.2 Gm4301 Gm4308 Gm4312 K9J7E2 K9J7E2_MOUSE NM_001166636 uc011xmq.1 uc011xmq.2 uc011xmq.3 molecular_function nucleic acid binding RNA binding cellular_component biological_process uc011xmq.1 uc011xmq.2 uc011xmq.3 
ENSMUST00000190266.4 Gm10421 ENSMUST00000190266.4 predicted gene 10421 (from RefSeq NR_033538.1) ENSMUST00000190266.1 ENSMUST00000190266.2 ENSMUST00000190266.3 NR_033538 uc007phz.1 uc007phz.2 uc007phz.3 uc007phz.4 uc007phz.5 uc007phz.6 uc007phz.1 uc007phz.2 uc007phz.3 uc007phz.4 uc007phz.5 uc007phz.6 
ENSMUST00000190279.7 Anapc13 ENSMUST00000190279.7 anaphase promoting complex subunit 13 (from RefSeq NM_181394.3) APC13_MOUSE ENSMUST00000190279.1 ENSMUST00000190279.2 ENSMUST00000190279.3 ENSMUST00000190279.4 ENSMUST00000190279.5 ENSMUST00000190279.6 NM_181394 Q8R034 uc009rft.1 uc009rft.2 uc009rft.3 uc009rft.4 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Protein modification; protein ubiquitination. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. Nucleus Belongs to the APC13 family. molecular_function nucleus anaphase-promoting complex cell cycle protein ubiquitination cell division protein K11-linked ubiquitination uc009rft.1 uc009rft.2 uc009rft.3 uc009rft.4 
ENSMUST00000190289.2 Gm28842 ENSMUST00000190289.2 Gm28842 (from geneSymbol) ENSMUST00000190289.1 uc292uiq.1 uc292uiq.2 uc292uiq.1 uc292uiq.2 
ENSMUST00000190292.2 Sly ENSMUST00000190292.2 Sycp3 like Y-linked (from RefSeq NM_201530.2) A0A087WRK1 A0A087WRK1_MOUSE ENSMUST00000190292.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 NM_201530 Sly uc029ybn.1 uc029ybn.2 uc029ybn.3 uc029ybn.4 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc029ybn.1 uc029ybn.2 uc029ybn.3 uc029ybn.4 
ENSMUST00000190294.3 4933404I11Rik ENSMUST00000190294.3 4933404I11Rik (from geneSymbol) AK016650 ENSMUST00000190294.1 ENSMUST00000190294.2 uc009glf.1 uc009glf.2 uc009glf.3 uc009glf.1 uc009glf.2 uc009glf.3 
ENSMUST00000190297.7 Gm29443 ENSMUST00000190297.7 predicted gene 29443, transcript variant 1 (from RefSeq NR_136928.1) ENSMUST00000190297.1 ENSMUST00000190297.2 ENSMUST00000190297.3 ENSMUST00000190297.4 ENSMUST00000190297.5 ENSMUST00000190297.6 NR_136928 uc057lsz.1 uc057lsz.2 uc057lsz.3 uc057lsz.1 uc057lsz.2 uc057lsz.3 
ENSMUST00000190301.2 Gm29137 ENSMUST00000190301.2 Gm29137 (from geneSymbol) ENSMUST00000190301.1 uc290ecf.1 uc290ecf.2 uc290ecf.1 uc290ecf.2 
ENSMUST00000190305.2 Gm29572 ENSMUST00000190305.2 Gm29572 (from geneSymbol) ENSMUST00000190305.1 uc290ije.1 uc290ije.2 uc290ije.1 uc290ije.2 
ENSMUST00000190311.2 Gm29233 ENSMUST00000190311.2 Gm29233 (from geneSymbol) ENSMUST00000190311.1 uc289zlj.1 uc289zlj.2 uc289zlj.1 uc289zlj.2 
ENSMUST00000190314.2 Gm21562 ENSMUST00000190314.2 Gm21562 (from geneSymbol) ENSMUST00000190314.1 FJ386436 uc292sxi.1 uc292sxi.2 uc292sxi.1 uc292sxi.2 
ENSMUST00000190315.2 Gm21874 ENSMUST00000190315.2 Belongs to the SPIN/STSY family. (from UniProt J3QNZ6) ENSMUST00000190315.1 Gm21874 J3QNZ6 J3QNZ6_MOUSE uc292seg.1 uc292seg.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292seg.1 uc292seg.2 
ENSMUST00000190319.2 Gm28259 ENSMUST00000190319.2 Gm28259 (from geneSymbol) ENSMUST00000190319.1 uc292umk.1 uc292umk.2 uc292umk.1 uc292umk.2 
ENSMUST00000190325.7 Gm28690 ENSMUST00000190325.7 Gm28690 (from geneSymbol) DQ874391 ENSMUST00000190325.1 ENSMUST00000190325.2 ENSMUST00000190325.3 ENSMUST00000190325.4 ENSMUST00000190325.5 ENSMUST00000190325.6 uc029ydn.1 uc029ydn.2 uc029ydn.1 uc029ydn.2 
ENSMUST00000190329.2 Gm21292 ENSMUST00000190329.2 predicted gene, 21292 (from RefSeq NM_001373891.1) ENSMUST00000190329.1 Gm21292 NM_001373891 Q78EE2 Q78EE2_MOUSE uc292sdu.1 uc292sdu.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sdu.1 uc292sdu.2 
ENSMUST00000190335.2 Gm29632 ENSMUST00000190335.2 Gm29632 (from geneSymbol) ENSMUST00000190335.1 uc292udv.1 uc292udv.2 uc292udv.1 uc292udv.2 
ENSMUST00000190341.7 Birc2 ENSMUST00000190341.7 baculoviral IAP repeat-containing 2, transcript variant 1 (from RefSeq NM_007465.3) A6H6S7 BIRC2_MOUSE ENSMUST00000190341.1 ENSMUST00000190341.2 ENSMUST00000190341.3 ENSMUST00000190341.4 ENSMUST00000190341.5 ENSMUST00000190341.6 NM_007465 O08864 Q62210 uc057ccx.1 uc057ccx.2 uc057ccx.3 Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING domain dimerization and E2 ubiquitin donor binding and activation. The CARD domain-mediated autoinhibition of the E3 ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability of BIRC2/c-IAP1 by preventing its ubiquitination (By similarity). Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with CASP9. Interacts (via BIR domains) with TRAF2; the interaction is required for IKBKE ubiquitination. Interacts with E2F1, RIPK1, RIPK2, RIPK3, RIPK4, BIRC5/survivin and USP19 (By similarity). Interacts with HSP90AB1 (By similarity). Interacts with several death receptors, inclusing FAS, TNFRSF10A and TNFRSF10B (By similarity). Recruited to TNFRSF10B in the absence of receptor stimulation. When TNFRSF10B is stimulated, further recruited to the receptor and cleaved by caspases. Proteolytic fragments remain associated with TNFRSF10B (By similarity). Cytoplasm Nucleus Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells (By similarity). Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. The BIR domains mediate nuclear localization. The CARD domain is necessary to stabilize the protein and inhibit the activation of E3 ubiquitin-protein ligase activity of BIRC2/c-IAP1 by preventing RING domain dimerization and E2 ubiquitin donor binding and activation. Auto-ubiquitinated and degraded by the proteasome in apoptotic cells. Upon stimulation of death receptors, including TNFRSF10B, recruited to receptors and cleaved by caspases. Proteolytic fragments remain associated with the receptors. This cleavage presumably inactivates the protein. Belongs to the IAP family. protein polyubiquitination response to hypoxia XY body placenta development transcription coactivator activity ubiquitin-protein transferase activity protein binding nucleus cytoplasm apoptotic process zinc ion binding cytoplasmic side of plasma membrane response to organonitrogen compound response to organic cyclic compound transferase activity positive regulation of protein ubiquitination macromolecular complex CD40 receptor complex identical protein binding regulation of apoptotic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process membrane raft response to ethanol metal ion binding protein N-terminus binding chaperone binding protein heterooligomerization response to cAMP regulation of cell cycle regulation of necroptotic process negative regulation of necroptotic process ubiquitin protein ligase activity necroptotic process cellular response to tumor necrosis factor FBXO family protein binding regulation of NIK/NF-kappaB signaling negative regulation of ripoptosome assembly involved in necroptotic process positive regulation of protein K63-linked ubiquitination positive regulation of protein K48-linked ubiquitination positive regulation of protein monoubiquitination positive regulation of protein polyubiquitination positive regulation of nucleic acid-templated transcription inhibition of cysteine-type endopeptidase activity involved in apoptotic process regulation of reactive oxygen species metabolic process uc057ccx.1 uc057ccx.2 uc057ccx.3 
ENSMUST00000190343.2 Gm28517 ENSMUST00000190343.2 Gm28517 (from geneSymbol) ENSMUST00000190343.1 FJ386436 uc292szy.1 uc292szy.2 uc292szy.1 uc292szy.2 
ENSMUST00000190347.7 Gm28318 ENSMUST00000190347.7 Gm28318 (from geneSymbol) ENSMUST00000190347.1 ENSMUST00000190347.2 ENSMUST00000190347.3 ENSMUST00000190347.4 ENSMUST00000190347.5 ENSMUST00000190347.6 uc292tnn.1 uc292tnn.2 uc292tnn.1 uc292tnn.2 
ENSMUST00000190349.2 Gm20806 ENSMUST00000190349.2 Belongs to the SPIN/STSY family. (from UniProt Q9D9T3) ENSMUST00000190349.1 Gm20806 Q9D9T3 Q9D9T3_MOUSE uc029yga.1 uc029yga.2 uc029yga.3 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc029yga.1 uc029yga.2 uc029yga.3 
ENSMUST00000190367.2 Gm28884 ENSMUST00000190367.2 Gm28884 (from geneSymbol) AK032227 ENSMUST00000190367.1 uc287jyp.1 uc287jyp.2 uc287jyp.1 uc287jyp.2 
ENSMUST00000190374.2 Gm29117 ENSMUST00000190374.2 Gm29117 (from geneSymbol) ENSMUST00000190374.1 uc292tmv.1 uc292tmv.2 uc292tmv.1 uc292tmv.2 
ENSMUST00000190378.2 Prmt6 ENSMUST00000190378.2 Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:22904064, PubMed:26070566). Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (By similarity). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (By similarity). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (By similarity). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:22904064). Repression of TP53 blocks cellular senescence (PubMed:22904064). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively) (By similarity). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (By similarity). Methylates HMGA1 (By similarity). Regulates alternative splicing events (By similarity). Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1 (By similarity). Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (PubMed:24570487). Methylates GPS2, protecting GPS2 from ubiquitination and degradation (PubMed:26070566). Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (By similarity). (from UniProt Q6NZB1) AK087608 ANM6_MOUSE ENSMUST00000190378.1 Hrmt1l6 Q3TA42 Q6NZB1 Q8BN52 Q8BSC2 Q8R5D7 uc290ivy.1 uc290ivy.2 Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:22904064, PubMed:26070566). Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (By similarity). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (By similarity). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (By similarity). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:22904064). Repression of TP53 blocks cellular senescence (PubMed:22904064). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively) (By similarity). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (By similarity). Methylates HMGA1 (By similarity). Regulates alternative splicing events (By similarity). Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1 (By similarity). Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (PubMed:24570487). Methylates GPS2, protecting GPS2 from ubiquitination and degradation (PubMed:26070566). Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (By similarity). Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA- COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319; Evidence=; Interacts with (and methylates) HIV-1 Tat, Rev and Nucleocapsid protein p7 (NC). Interacts with EPB41L3 and NCOA1. Nucleus Automethylation enhances its stability. Embryonic fibroblasts from mutant mice display growth defects, premature senescence and increased levels of TP53 and multiple TP53 targets. In liver, knockdown disrupts the formation of a cAMP-mediated transcription complex involving CRTC2, reduces the expression of genes encoding gluconeogenic factors and decreases glucose output in primary hepatocytes, it also restores euglycemia in insulin-resistant mice. Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT6 subfamily. Sequence=BAC28811.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC39923.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter chromatin binding protein binding nucleus nucleolus DNA repair chromatin organization protein methylation cellular response to DNA damage stimulus methyltransferase activity histone-arginine N-methyltransferase activity protein-arginine N-methyltransferase activity histone methylation transferase activity peptidyl-arginine methylation, to asymmetrical-dimethyl arginine methylation histone H3-R2 methylation protein-arginine omega-N monomethyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity peptidyl-arginine N-methylation histone methyltransferase activity histone binding histone H4-R3 methylation histone methyltransferase activity (H4-R3 specific) negative regulation of transcription, DNA-templated negative regulation of histone H3-K4 methylation histone methyltransferase activity (H3-R2 specific) histone methyltransferase activity (H2A-R3 specific) cellular senescence regulation of signal transduction by p53 class mediator uc290ivy.1 uc290ivy.2 
ENSMUST00000190390.7 Srcap ENSMUST00000190390.7 Nucleus (from UniProt A0A087WNL7) A0A087WNL7 A0A087WNL7_MOUSE AK154145 ENSMUST00000190390.1 ENSMUST00000190390.2 ENSMUST00000190390.3 ENSMUST00000190390.4 ENSMUST00000190390.5 ENSMUST00000190390.6 Srcap uc291vvp.1 uc291vvp.2 Nucleus Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. Swr1 complex DNA binding ATP binding nucleus nucleoplasm Golgi apparatus chromatin remodeling gene silencing nuclear body ATPase activity macromolecular complex histone binding ATP-dependent chromatin remodeling histone exchange perinuclear region of cytoplasm uc291vvp.1 uc291vvp.2 
ENSMUST00000190391.2 Gm21854 ENSMUST00000190391.2 Belongs to the SPIN/STSY family. (from UniProt A0A087WNM4) A0A087WNM4 A0A087WNM4_MOUSE ENSMUST00000190391.1 Gm21854 uc292rzz.1 uc292rzz.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292rzz.1 uc292rzz.2 
ENSMUST00000190392.4 Gm29266 ENSMUST00000190392.4 Gm29266 (from geneSymbol) ENSMUST00000190392.1 ENSMUST00000190392.2 ENSMUST00000190392.3 uc288uzd.1 uc288uzd.2 uc288uzd.3 uc288uzd.4 uc288uzd.1 uc288uzd.2 uc288uzd.3 uc288uzd.4 
ENSMUST00000190396.2 Gm29590 ENSMUST00000190396.2 Gm29590 (from geneSymbol) BC025201 ENSMUST00000190396.1 uc288mbw.1 uc288mbw.2 uc288mbw.1 uc288mbw.2 
ENSMUST00000190399.2 ENSMUSG00000121461 ENSMUST00000190399.2 ENSMUSG00000121461 (from geneSymbol) ENSMUST00000190399.1 uc292sco.1 uc292sco.2 uc292sco.1 uc292sco.2 
ENSMUST00000190408.2 Gm28532 ENSMUST00000190408.2 Gm28532 (from geneSymbol) ENSMUST00000190408.1 uc292ttx.1 uc292ttx.2 uc292ttx.1 uc292ttx.2 
ENSMUST00000190417.7 Gm28293 ENSMUST00000190417.7 Gm28293 (from geneSymbol) ENSMUST00000190417.1 ENSMUST00000190417.2 ENSMUST00000190417.3 ENSMUST00000190417.4 ENSMUST00000190417.5 ENSMUST00000190417.6 uc292tqw.1 uc292tqw.2 uc292tqw.1 uc292tqw.2 
ENSMUST00000190424.7 Gm28074 ENSMUST00000190424.7 Gm28074 (from geneSymbol) ENSMUST00000190424.1 ENSMUST00000190424.2 ENSMUST00000190424.3 ENSMUST00000190424.4 ENSMUST00000190424.5 ENSMUST00000190424.6 uc292tvb.1 uc292tvb.2 uc292tvb.1 uc292tvb.2 
ENSMUST00000190426.2 Gm20830 ENSMUST00000190426.2 Belongs to the SPIN/STSY family. (from UniProt J3KML6) ENSMUST00000190426.1 Gm20830 J3KML6 J3KML6_MOUSE uc292sbi.1 uc292sbi.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sbi.1 uc292sbi.2 
ENSMUST00000190429.2 Gm28789 ENSMUST00000190429.2 Gm28789 (from geneSymbol) ENSMUST00000190429.1 uc292unw.1 uc292unw.2 uc292unw.1 uc292unw.2 
ENSMUST00000190431.3 1700052I22Rik ENSMUST00000190431.3 1700052I22Rik (from geneSymbol) AK018974 ENSMUST00000190431.1 ENSMUST00000190431.2 uc007obk.1 uc007obk.2 uc007obk.3 uc007obk.4 uc007obk.5 uc007obk.1 uc007obk.2 uc007obk.3 uc007obk.4 uc007obk.5 
ENSMUST00000190433.2 Slurp1 ENSMUST00000190433.2 secreted Ly6/Plaur domain containing 1 (from RefSeq NM_020519.2) Ars ENSMUST00000190433.1 NM_020519 Q2TA55 Q9Z0K7 SLUR1_MOUSE uc007wft.1 uc007wft.2 uc007wft.3 Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7- dependent nAChR currents in an allosteric manner (By similarity). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have a immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:23139280, PubMed:25168896). Homodimer (By similarity). Interacts with PLAU (PubMed:25168896). Interacts with CHRNA7. Q9Z0K7; P06869: Plau; NbExp=4; IntAct=EBI-14060702, EBI-8365661; Secreted Expressed in skin, eye, whole lung, trachea, esophagus and stomach (PubMed:14721776). Widely expressed in various tissues including spleen and thymus but not pancreas. Expressed in macrophages, dendritic cells, T and B cells (PubMed:17286989). Expressed in lung specifically in ciliated bronchial epithelial cells (at protein level). Expression is decreased in lungs of asthmatic model mice(PubMed:19396877, PubMed:20621062). Expressed in the cornea (PubMed:23139280). Down-regulated in the cornea under pro-inflammatory conditions. Severe palmoplantar keratoderma, reduced adiposity, protection from obesity on a high-fat diet, low plasma lipid levels, and neuromuscular abnormality (hind-limb clasping). cytokine activity protein binding extracellular region extracellular space locomotory behavior negative regulation of cell proliferation negative regulation of keratinocyte proliferation negative regulation of cell migration acetylcholine receptor activator activity urokinase plasminogen activator signaling pathway neuromuscular process controlling posture regulation of neurotransmitter receptor activity uc007wft.1 uc007wft.2 uc007wft.3 
ENSMUST00000190434.2 Gm29003 ENSMUST00000190434.2 Gm29003 (from geneSymbol) ENSMUST00000190434.1 uc292ucl.1 uc292ucl.2 uc292ucl.1 uc292ucl.2 
ENSMUST00000190436.7 Redic1 ENSMUST00000190436.7 Involved in recombination, probably acting by stabilizing recombination intermediates during meiotic crossover formation (PubMed:37612290, PubMed:37604834). Required for normal germline development and fertility (PubMed:37612290, PubMed:37604834). Required for meiotic progression, complete chromosomal synapsis and crossover formation (PubMed:37612290, PubMed:37604834). Binds double-stranded DNA (PubMed:37604834). However, also binds branched DNA molecules, such as those containing a D-loop or Holliday junction structure (PubMed:37612290). Probably not required for formation of DNA double- strand breaks (DSBs) (PubMed:37604834). Also binds RNA in an RNA structure-independent manner, with a preference for binding 3'-UTR regions of mRNAs; may stabilize bound RNAs (PubMed:37604834). (from UniProt A0A087WRU1) A0A087WRU1 CN725425 ENSMUST00000190436.1 ENSMUST00000190436.2 ENSMUST00000190436.3 ENSMUST00000190436.4 ENSMUST00000190436.5 ENSMUST00000190436.6 RDIC1_MOUSE Redic1 uc289atc.1 uc289atc.2 Involved in recombination, probably acting by stabilizing recombination intermediates during meiotic crossover formation (PubMed:37612290, PubMed:37604834). Required for normal germline development and fertility (PubMed:37612290, PubMed:37604834). Required for meiotic progression, complete chromosomal synapsis and crossover formation (PubMed:37612290, PubMed:37604834). Binds double-stranded DNA (PubMed:37604834). However, also binds branched DNA molecules, such as those containing a D-loop or Holliday junction structure (PubMed:37612290). Probably not required for formation of DNA double- strand breaks (DSBs) (PubMed:37604834). Also binds RNA in an RNA structure-independent manner, with a preference for binding 3'-UTR regions of mRNAs; may stabilize bound RNAs (PubMed:37604834). Interacts with MSH5 (PubMed:37612290). Interacts with TEX11 (PubMed:37612290). Chromosome Note=In pachytene spermatocytes, localized along autosomal axes and the synapsed pseudoautosomal region on sex chromosomes, decreasing rapidly after early pachytene, by mid- or late pachytene, and disappearing in the diplotene stage (PubMed:37612290). Also detected on the paired regions of homologous chromosomes in zygotene and pachytene oocytes, colocalizing with MSH4 (PubMed:37612290). Chromosomal localization of REDIC1 is mainly dependent on meiotic DNA double-strand breaks (DSBs) and interhomolog strand invasion (PubMed:37612290). In spermatocytes from early zygotene to early pachytene, more than 90% of REDIC1 foci colocalize with RPA2 (PubMed:37612290). Probably localizes first to recombination intermediates and later colocalizes with MLH1 at crossover sites (PubMed:37612290). Expressed mainly in testis (at protein level) (PubMed:37604834). Expressed in spermatogonia and enriched in spermatocytes; absent in testicular somatic cells (at protein level) (PubMed:37604834). No expression or low levels in other tissues (PubMed:37612290). Expressed in embryonic ovaries at 14.5 days post- conception (dpc). The N-terminal region (residues 1-228) binds branched DNA molecules, such as those containing a D-loop (PubMed:37612290). A truncated N-terminal region (residues 1-78), binds very poorly to similar DNA molecules (PubMed:37612290). molecular_function cellular_component biological_process uc289atc.1 uc289atc.2 
ENSMUST00000190437.2 Gm28206 ENSMUST00000190437.2 Gm28206 (from geneSymbol) ENSMUST00000190437.1 uc292tsq.1 uc292tsq.2 uc292tsq.1 uc292tsq.2 
ENSMUST00000190453.2 Gm29276 ENSMUST00000190453.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WNW5) A0A087WNW5 A0A087WNW5_MOUSE AK076905 ENSMUST00000190453.1 Gm29276 uc292thk.1 uc292thk.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292thk.1 uc292thk.2 
ENSMUST00000190456.2 Krtap5-2 ENSMUST00000190456.2 keratin associated protein 5-2 (from RefSeq NM_027844.4) A0A087WRV2 A0A087WRV2_MOUSE ENSMUST00000190456.1 Krtap5-2 NM_027844 uc029wpw.1 uc029wpw.2 uc029wpw.3 keratin filament uc029wpw.1 uc029wpw.2 uc029wpw.3 
ENSMUST00000190457.2 Misp3 ENSMUST00000190457.2 MISP family member 3 (from RefSeq NM_001291292.1) 2210011C24Rik A0A087WQ89 A0A087WQ89_MOUSE ENSMUST00000190457.1 Misp3 NM_001291292 uc009mlp.1 uc009mlp.2 uc009mlp.3 uc009mlp.4 molecular_function cellular_component biological_process uc009mlp.1 uc009mlp.2 uc009mlp.3 uc009mlp.4 
ENSMUST00000190463.2 Gm28620 ENSMUST00000190463.2 Gm28620 (from geneSymbol) ENSMUST00000190463.1 uc292jbr.1 uc292jbr.2 uc292jbr.1 uc292jbr.2 
ENSMUST00000190466.2 Gm28505 ENSMUST00000190466.2 Gm28505 (from geneSymbol) AK080902 ENSMUST00000190466.1 uc008akl.1 uc008akl.2 uc008akl.1 uc008akl.2 
ENSMUST00000190488.3 BC055402 ENSMUST00000190488.3 cDNA sequence BC055402 (from RefSeq NR_037990.1) ENSMUST00000190488.1 ENSMUST00000190488.2 NR_037990 uc007bav.1 uc007bav.2 uc007bav.3 uc007bav.4 uc007bav.5 uc007bav.1 uc007bav.2 uc007bav.3 uc007bav.4 uc007bav.5 
ENSMUST00000190505.3 Or9s27 ENSMUST00000190505.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VET3) ENSMUST00000190505.1 ENSMUST00000190505.2 Olfr1412 Or9s27 Q8VET3 Q8VET3_MOUSE uc287kme.1 uc287kme.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287kme.1 uc287kme.2 
ENSMUST00000190512.2 Tcstv1a ENSMUST00000190512.2 2 cell stage variable group member 1A (from RefSeq NM_018756.3) ENSMUST00000190512.1 NM_018756 O70619 O70619_MOUSE Tcstv1 uc029sdp.1 uc029sdp.2 uc029sdp.3 uc029sdp.4 molecular_function cellular_component biological_process uc029sdp.1 uc029sdp.2 uc029sdp.3 uc029sdp.4 
ENSMUST00000190516.2 Gm20828 ENSMUST00000190516.2 Belongs to the SPIN/STSY family. (from UniProt J3KMI7) ENSMUST00000190516.1 Gm20822 Gm20828 J3KMI7 J3KMI7_MOUSE uc292sfv.1 uc292sfv.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sfv.1 uc292sfv.2 
ENSMUST00000190517.2 Gm28858 ENSMUST00000190517.2 Gm28858 (from geneSymbol) ENSMUST00000190517.1 uc292ssp.1 uc292ssp.2 uc292ssp.1 uc292ssp.2 
ENSMUST00000190521.7 Gm28456 ENSMUST00000190521.7 Gm28456 (from geneSymbol) DQ874391 ENSMUST00000190521.1 ENSMUST00000190521.2 ENSMUST00000190521.3 ENSMUST00000190521.4 ENSMUST00000190521.5 ENSMUST00000190521.6 uc029xza.1 uc029xza.2 uc029xza.1 uc029xza.2 
ENSMUST00000190523.7 ENSMUSG00000121333 ENSMUST00000190523.7 ENSMUSG00000121333 (from geneSymbol) ENSMUST00000190523.1 ENSMUST00000190523.2 ENSMUST00000190523.3 ENSMUST00000190523.4 ENSMUST00000190523.5 ENSMUST00000190523.6 uc292udm.1 uc292udm.2 uc292udm.1 uc292udm.2 
ENSMUST00000190542.2 Gm28458 ENSMUST00000190542.2 Gm28458 (from geneSymbol) ENSMUST00000190542.1 uc292tiz.1 uc292tiz.2 uc292tiz.1 uc292tiz.2 
ENSMUST00000190543.2 Gm29023 ENSMUST00000190543.2 Gm29023 (from geneSymbol) ENSMUST00000190543.1 uc292tdf.1 uc292tdf.2 uc292tdf.1 uc292tdf.2 
ENSMUST00000190551.7 Gm21650 ENSMUST00000190551.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WSL2) A0A087WSL2 A0A087WSL2_MOUSE ENSMUST00000190551.1 ENSMUST00000190551.2 ENSMUST00000190551.3 ENSMUST00000190551.4 ENSMUST00000190551.5 ENSMUST00000190551.6 FJ541091 Gm21650 uc292upu.1 uc292upu.2 Belongs to the XLR/SYCP3 family. uc292upu.1 uc292upu.2 
ENSMUST00000190554.2 Gm4567 ENSMUST00000190554.2 predicted gene 4567 (from RefSeq NM_001037248.3) EG381936 ENSMUST00000190554.1 Gm10668 Gm4567 Gm6902 NM_001037248 Q3UTA8 Q3UTA8_MOUSE uc009fob.1 uc009fob.2 uc009fob.3 uc009fob.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. nucleotide binding microtubule cytoskeleton organization molecular_function protein kinase activity protein serine/threonine kinase activity ATP binding cellular_component cytoplasm protein phosphorylation biological_process intracellular signal transduction tau-protein kinase activity uc009fob.1 uc009fob.2 uc009fob.3 uc009fob.4 
ENSMUST00000190561.7 Gm28522 ENSMUST00000190561.7 Gm28522 (from geneSymbol) ENSMUST00000190561.1 ENSMUST00000190561.2 ENSMUST00000190561.3 ENSMUST00000190561.4 ENSMUST00000190561.5 ENSMUST00000190561.6 uc292szw.1 uc292szw.2 uc292szw.1 uc292szw.2 
ENSMUST00000190565.2 Ssty2 ENSMUST00000190565.2 spermiogenesis specific transcript on the Y 2 (from RefSeq NM_023546.3) ENSMUST00000190565.1 NM_023546 Q149W4 Q149W4_MOUSE Ssty2 uc029yev.1 uc029yev.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation biological_process methylated histone binding uc029yev.1 uc029yev.2 
ENSMUST00000190567.2 A630072M18Rik ENSMUST00000190567.2 RIKEN cDNA A630072M18 gene (from RefSeq NR_030699.1) ENSMUST00000190567.1 NR_030699 uc008wog.1 uc008wog.2 uc008wog.3 uc008wog.1 uc008wog.2 uc008wog.3 
ENSMUST00000190569.2 Gm29531 ENSMUST00000190569.2 Gm29531 (from geneSymbol) ENSMUST00000190569.1 FJ386436 uc292tab.1 uc292tab.2 uc292tab.1 uc292tab.2 
ENSMUST00000190571.7 Clasp1 ENSMUST00000190571.7 CLIP associating protein 1, transcript variant 13 (from RefSeq NM_001359337.1) A0A087WQ31 A0A087WQ31_MOUSE Clasp1 ENSMUST00000190571.1 ENSMUST00000190571.2 ENSMUST00000190571.3 ENSMUST00000190571.4 ENSMUST00000190571.5 ENSMUST00000190571.6 NM_001359337 uc287lbv.1 uc287lbv.2 Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Golgi apparatus, trans-Golgi network kinetochore microtubule cytoplasmic microtubule kinetochore binding microtubule plus-end binding uc287lbv.1 uc287lbv.2 
ENSMUST00000190572.2 Gm28510 ENSMUST00000190572.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WP28) A0A087WP28 A0A087WP28_MOUSE ENSMUST00000190572.1 Gm28510 uc292sfb.1 uc292sfb.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292sfb.1 uc292sfb.2 
ENSMUST00000190573.2 Gm28961 ENSMUST00000190573.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WPA5) A0A087WPA5 A0A087WPA5_MOUSE ENSMUST00000190573.1 Gm28961 uc292tuc.1 uc292tuc.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292tuc.1 uc292tuc.2 
ENSMUST00000190577.2 Gm21914 ENSMUST00000190577.2 Gm21914 (from geneSymbol) ENSMUST00000190577.1 FJ386436 uc292tfw.1 uc292tfw.2 uc292tfw.1 uc292tfw.2 
ENSMUST00000190581.2 C330022C24Rik ENSMUST00000190581.2 RIKEN cDNA C330022C24 gene (from RefSeq NR_045717.1) ENSMUST00000190581.1 NR_045717 uc029wpk.1 uc029wpk.2 uc029wpk.1 uc029wpk.2 
ENSMUST00000190590.2 Gm28460 ENSMUST00000190590.2 Gm28460 (from geneSymbol) ENSMUST00000190590.1 uc292tjf.1 uc292tjf.2 uc292tjf.1 uc292tjf.2 
ENSMUST00000190591.10 Nadk2 ENSMUST00000190591.10 NAD kinase 2, mitochondrial, transcript variant 1 (from RefSeq NM_001085410.2) ENSMUST00000190591.1 ENSMUST00000190591.2 ENSMUST00000190591.3 ENSMUST00000190591.4 ENSMUST00000190591.5 ENSMUST00000190591.6 ENSMUST00000190591.7 ENSMUST00000190591.8 ENSMUST00000190591.9 Mnadk NAKD2_MOUSE NM_001085410 Nadkd1 Q3TRP5 Q3UEY1 Q8C5H8 Q9CTE4 uc288wxa.1 uc288wxa.2 Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor (By similarity). Reaction=ATP + NAD(+) = ADP + H(+) + NADP(+); Xref=Rhea:RHEA:18629, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57540, ChEBI:CHEBI:58349, ChEBI:CHEBI:456216; EC=2.7.1.23; Inhibited by NADH, NADPH and NADP(+). Homodimer. Mitochondrion Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8C5H8-1; Sequence=Displayed; Name=2; IsoId=Q8C5H8-2; Sequence=VSP_027195, VSP_027196; Name=3; IsoId=Q8C5H8-3; Sequence=VSP_027195; Name=4; IsoId=Q8C5H8-4; Sequence=VSP_027194, VSP_027195; Belongs to the NAD kinase family. Sequence=BAB23041.1; Type=Frameshift; Evidence=; Sequence=BAE28780.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleotide binding NAD+ kinase activity ATP binding mitochondrion NADP biosynthetic process kinase activity phosphorylation transferase activity NAD metabolic process protein homodimerization activity uc288wxa.1 uc288wxa.2 
ENSMUST00000190598.3 Gm29017 ENSMUST00000190598.3 Gm29017 (from geneSymbol) AK041968 ENSMUST00000190598.1 ENSMUST00000190598.2 uc287ill.1 uc287ill.2 uc287ill.3 uc287ill.1 uc287ill.2 uc287ill.3 
ENSMUST00000190611.2 Gm29078 ENSMUST00000190611.2 Gm29078 (from geneSymbol) ENSMUST00000190611.1 uc292tau.1 uc292tau.2 uc292tau.1 uc292tau.2 
ENSMUST00000190621.7 ENSMUSG00000121289 ENSMUST00000190621.7 ENSMUSG00000121289 (from geneSymbol) ENSMUST00000190621.1 ENSMUST00000190621.2 ENSMUST00000190621.3 ENSMUST00000190621.4 ENSMUST00000190621.5 ENSMUST00000190621.6 uc292ujv.1 uc292ujv.2 uc292ujv.1 uc292ujv.2 
ENSMUST00000190627.2 Gm29566 ENSMUST00000190627.2 Gm29566 (from geneSymbol) ENSMUST00000190627.1 uc292uqg.1 uc292uqg.2 uc292uqg.1 uc292uqg.2 
ENSMUST00000190631.2 Gm28210 ENSMUST00000190631.2 Gm28210 (from geneSymbol) ENSMUST00000190631.1 uc292syz.1 uc292syz.2 uc292syz.1 uc292syz.2 
ENSMUST00000190637.7 Bckdhb ENSMUST00000190637.7 branched chain ketoacid dehydrogenase E1, beta polypeptide, transcript variant 4 (from RefSeq NM_001410184.1) Bckdhb ENSMUST00000190637.1 ENSMUST00000190637.2 ENSMUST00000190637.3 ENSMUST00000190637.4 ENSMUST00000190637.5 ENSMUST00000190637.6 NM_001410184 ODBB_MOUSE Q6P3A8 uc009qwr.1 uc009qwr.2 uc009qwr.3 uc009qwr.4 Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. Reaction=3-methyl-2-oxobutanoate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl- [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] = CO2 + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl- [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]; Xref=Rhea:RHEA:13457, Rhea:RHEA-COMP:10488, Rhea:RHEA-COMP:10489, ChEBI:CHEBI:11851, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:83099, ChEBI:CHEBI:83142; EC=1.2.4.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13458; Evidence=; Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Heterotetramer of 2 alpha/BCKDHA and 2 beta chains/BCKDHB that forms the branched-chain alpha-keto acid decarboxylase (E1) component of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase is a large complex composed of three major building blocks E1, E2 and E3. It is organized around E2, a 24-meric cubic core composed of DBT, to which are associated 6 to 12 copies of E1, and approximately 6 copies of the dehydrogenase E3, a DLD dimer. Mitochondrion matrix Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P3A8-1; Sequence=Displayed; Name=2; IsoId=Q6P3A8-2; Sequence=VSP_029841; catalytic activity alpha-ketoacid dehydrogenase activity 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity mitochondrion mitochondrial inner membrane mitochondrial matrix mitochondrial alpha-ketoglutarate dehydrogenase complex response to nutrient cellular amino acid catabolic process branched-chain amino acid catabolic process oxidoreductase activity macromolecular complex binding oxidation-reduction process uc009qwr.1 uc009qwr.2 uc009qwr.3 uc009qwr.4 
ENSMUST00000190641.7 Mturn ENSMUST00000190641.7 maturin, neural progenitor differentiation regulator homolog (Xenopus), transcript variant 1 (from RefSeq NM_001289740.1) ENSMUST00000190641.1 ENSMUST00000190641.2 ENSMUST00000190641.3 ENSMUST00000190641.4 ENSMUST00000190641.5 ENSMUST00000190641.6 MTURN_MOUSE NM_001289740 Q8CGA4 uc009cad.1 uc009cad.2 uc009cad.3 uc009cad.4 uc009cad.5 Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (PubMed:24681962). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser- 536' (By similarity). May be involved in early neuronal development (By similarity). Cytoplasm Expressed in the thymus, bone marrow and spleen. Expressed in embryo throughout the early nervous system. Strongly expressed in differentiating neurons in the brain, spinal cord and retina. Not detected in the lens at any developmental stage tested. Phosphorylation at Tyr-34 is essential for its ability to promote megakaryocyte differentiation. Belongs to the MTURN family. molecular_function cellular_component multicellular organism development neuron development uc009cad.1 uc009cad.2 uc009cad.3 uc009cad.4 uc009cad.5 
ENSMUST00000190647.3 Begain ENSMUST00000190647.3 brain-enriched guanylate kinase-associated, transcript variant 1 (from RefSeq NM_001374200.1) A0A087WQY4 Begain ENSMUST00000190647.1 ENSMUST00000190647.2 F8WIG2 F8WIG2_MOUSE NM_001374200 uc007pal.1 uc007pal.2 uc007pal.3 Membrane ; Peripheral membrane protein uc007pal.1 uc007pal.2 uc007pal.3 
ENSMUST00000190650.2 Gm28811 ENSMUST00000190650.2 Gm28811 (from geneSymbol) ENSMUST00000190650.1 uc292tcw.1 uc292tcw.2 uc292tcw.1 uc292tcw.2 
ENSMUST00000190657.2 Gm28264 ENSMUST00000190657.2 Gm28264 (from geneSymbol) ENSMUST00000190657.1 uc292tbs.1 uc292tbs.2 uc292tbs.1 uc292tbs.2 
ENSMUST00000190660.7 Gm29373 ENSMUST00000190660.7 Gm29373 (from geneSymbol) DQ874392 ENSMUST00000190660.1 ENSMUST00000190660.2 ENSMUST00000190660.3 ENSMUST00000190660.4 ENSMUST00000190660.5 ENSMUST00000190660.6 uc292tkq.1 uc292tkq.2 uc292tkq.1 uc292tkq.2 
ENSMUST00000190663.2 Gm28513 ENSMUST00000190663.2 RIKEN cDNA C230024C17 gene (from RefSeq NR_046171.1) ENSMUST00000190663.1 NR_046171 uc029que.1 uc029que.2 uc029que.1 uc029que.2 
ENSMUST00000190665.2 Xrn1 ENSMUST00000190665.2 Belongs to the 5'-3' exonuclease family. (from UniProt A0A087WNV6) A0A087WNV6 A0A087WNV6_MOUSE BC100578 ENSMUST00000190665.1 Xrn1 uc009rbw.1 uc009rbw.2 uc009rbw.3 Belongs to the 5'-3' exonuclease family. nuclear-transcribed mRNA catabolic process nucleic acid binding exonuclease activity 5'-3' exonuclease activity nucleic acid phosphodiester bond hydrolysis uc009rbw.1 uc009rbw.2 uc009rbw.3 
ENSMUST00000190682.7 Gsdmc3 ENSMUST00000190682.7 gasdermin C3 (from RefSeq NM_183194.3) E9QJY6 ENSMUST00000190682.1 ENSMUST00000190682.2 ENSMUST00000190682.3 ENSMUST00000190682.4 ENSMUST00000190682.5 ENSMUST00000190682.6 GSDC3_MOUSE Gsdmc3 NM_183194 Q8CB12 uc007vza.1 uc007vza.2 uc007vza.3 uc007vza.4 [Gasdermin-C3]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C3, N-terminal) binds to membranes and forms pores, triggering pyroptosis. [Gasdermin-C3, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis. Produced by the cleavage of gasdermin-D by caspase CASP8 in response to death signals (By similarity). After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (By similarity). [Gasdermin-C3]: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C- terminal domains mediate autoinhibition in the absence of activation signal (By similarity). The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-C3, N-terminal) following cleavage by caspase CASP8 (By similarity). [Gasdermin-C3, N-terminal]: Homooligomer; homooligomeric ring- shaped pore complex containing 27-28 subunits when inserted in the membrane. [Gasdermin-C3]: Cytoplasm, cytosol [Gasdermin-C3, N-terminal]: Cell membrane ; Multi-pass membrane protein Intramolecular interactions between N- and C-terminal domains are important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain. Cleavage by CASP8 relieves autoinhibition by releasing the N- terminal moiety (Gasdermin-C3, N-terminal) that initiates pyroptosis. Belongs to the gasdermin family. phosphatidylserine binding phosphatidylinositol-4,5-bisphosphate binding cytoplasm mitochondrion microtubule organizing center cytosol plasma membrane programmed cell death membrane pyroptosis phosphatidylinositol-4-phosphate binding uc007vza.1 uc007vza.2 uc007vza.3 uc007vza.4 
ENSMUST00000190685.2 Gm28307 ENSMUST00000190685.2 Gm28307 (from geneSymbol) AK133320 ENSMUST00000190685.1 uc291oue.1 uc291oue.2 uc291oue.1 uc291oue.2 
ENSMUST00000190686.7 Srrm2 ENSMUST00000190686.7 serine/arginine repetitive matrix 2, transcript variant 1 (from RefSeq NM_001368687.1) E9QNB0 ENSMUST00000190686.1 ENSMUST00000190686.2 ENSMUST00000190686.3 ENSMUST00000190686.4 ENSMUST00000190686.5 ENSMUST00000190686.6 Kiaa0324 NM_001368687 Q3TBY5 Q569P9 Q80U37 Q8BTI8 Q8K383 SRRM2_MOUSE uc008atn.1 uc008atn.2 uc008atn.3 Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Component of pre-catalytic, catalytic and post-catalytic spliceosome complexes. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. Component of the minor spliceosome, which splices U12-type introns (By similarity). Interacts with DHX8. Interacts with CACTIN. Nucleus Nucleus speckle Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BTI8-1; Sequence=Displayed; Name=2; IsoId=Q8BTI8-2; Sequence=VSP_020188; Name=3; IsoId=Q8BTI8-3; Sequence=VSP_020189; Belongs to the CWC21 family. Sequence=AAH27781.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; mRNA splicing, via spliceosome mRNA binding nucleus spliceosomal complex mRNA processing biological_process RNA splicing Cajal body nuclear speck protein N-terminus binding C2H2 zinc finger domain binding U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome uc008atn.1 uc008atn.2 uc008atn.3 
ENSMUST00000190688.2 Gm20978 ENSMUST00000190688.2 Gm20978 (from geneSymbol) ENSMUST00000190688.1 uc292tvo.1 uc292tvo.2 uc292tvo.1 uc292tvo.2 
ENSMUST00000190690.3 2210011K15Rik ENSMUST00000190690.3 2210011K15Rik (from geneSymbol) AK008708 ENSMUST00000190690.1 ENSMUST00000190690.2 uc287lgi.1 uc287lgi.2 uc287lgi.3 uc287lgi.1 uc287lgi.2 uc287lgi.3 
ENSMUST00000190693.2 9130221H12Rik ENSMUST00000190693.2 RIKEN cDNA 9130221H12 gene (from RefSeq NR_046001.1) ENSMUST00000190693.1 NR_046001 uc012ffq.1 uc012ffq.2 uc012ffq.3 uc012ffq.4 uc012ffq.1 uc012ffq.2 uc012ffq.3 uc012ffq.4 
ENSMUST00000190699.4 2810402E24Rik ENSMUST00000190699.4 2810402E24Rik (from geneSymbol) AK012965 ENSMUST00000190699.1 ENSMUST00000190699.2 ENSMUST00000190699.3 uc288rhc.1 uc288rhc.2 uc288rhc.3 uc288rhc.4 uc288rhc.1 uc288rhc.2 uc288rhc.3 uc288rhc.4 
ENSMUST00000190703.7 Plin4 ENSMUST00000190703.7 perilipin 4, transcript variant 2 (from RefSeq NM_020568.4) E9QN72 ENSMUST00000190703.1 ENSMUST00000190703.2 ENSMUST00000190703.3 ENSMUST00000190703.4 ENSMUST00000190703.5 ENSMUST00000190703.6 Kiaa1881 NM_020568 O88492 PLIN4_MOUSE Q69Z80 Q8BNV5 uc008day.1 uc008day.2 uc008day.3 uc008day.4 May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets. Cell membrane Cytoplasm Lipid droplet te=Nascent lipid droplet surface- associated; association with lipid droplets is triacylglycerol synthesis-dependent. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88492-1; Sequence=Displayed; Name=2; IsoId=O88492-2; Sequence=VSP_027279, VSP_027280; Specifically expressed in white adipose tissue and also weakly detected in heart and skeletal muscle (at protein level). Up-regulated by PPARG and during adipocyte differentiation. Belongs to the perilipin family. Sequence=BAC37834.1; Type=Erroneous initiation; Evidence=; Sequence=BAD32564.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; cytoplasm lipid particle cytosol plasma membrane membrane intracellular membrane-bounded organelle uc008day.1 uc008day.2 uc008day.3 uc008day.4 
ENSMUST00000190704.3 Gm28729 ENSMUST00000190704.3 predicted gene 28729 (from RefSeq NM_001370882.1) A0A1B0GSW2 A0A1B0GSW2_MOUSE ENSMUST00000190704.1 ENSMUST00000190704.2 Gm28729 NM_001370882 uc292juj.1 uc292juj.2 uc292juj.1 uc292juj.2 
ENSMUST00000190705.2 Gm29325 ENSMUST00000190705.2 Gm29325 (from geneSymbol) ENSMUST00000190705.1 uc287hyj.1 uc287hyj.2 uc287hyj.1 uc287hyj.2 
ENSMUST00000190707.7 Gm5833 ENSMUST00000190707.7 predicted gene 5833 (from RefSeq NR_040304.1) ENSMUST00000190707.1 ENSMUST00000190707.2 ENSMUST00000190707.3 ENSMUST00000190707.4 ENSMUST00000190707.5 ENSMUST00000190707.6 NR_040304 uc007cvp.1 uc007cvp.2 uc007cvp.3 uc007cvp.1 uc007cvp.2 uc007cvp.3 
ENSMUST00000190708.7 1700017N19Rik ENSMUST00000190708.7 1700017N19Rik (from geneSymbol) 1700017N19Rik A0A087WPJ1 A0A087WPJ1_MOUSE AK006074 ENSMUST00000190708.1 ENSMUST00000190708.2 ENSMUST00000190708.3 ENSMUST00000190708.4 ENSMUST00000190708.5 ENSMUST00000190708.6 uc287unz.1 uc287unz.2 mRNA binding cell poly(A)+ mRNA export from nucleus metal ion binding transcription export complex uc287unz.1 uc287unz.2 
ENSMUST00000190714.6 Gm28834 ENSMUST00000190714.6 Gm28834 (from geneSymbol) ENSMUST00000190714.1 ENSMUST00000190714.2 ENSMUST00000190714.3 ENSMUST00000190714.4 ENSMUST00000190714.5 uc292thb.1 uc292thb.2 uc292thb.1 uc292thb.2 
ENSMUST00000190718.3 Gm29388 ENSMUST00000190718.3 Gm29388 (from geneSymbol) ENSMUST00000190718.1 ENSMUST00000190718.2 uc292kch.1 uc292kch.2 uc292kch.3 uc292kch.1 uc292kch.2 uc292kch.3 
ENSMUST00000190720.2 Gm29282 ENSMUST00000190720.2 Gm29282 (from geneSymbol) ENSMUST00000190720.1 uc287msf.1 uc287msf.2 uc287msf.1 uc287msf.2 
ENSMUST00000190722.2 Gm29527 ENSMUST00000190722.2 Gm29527 (from geneSymbol) ENSMUST00000190722.1 uc292sfi.1 uc292sfi.2 uc292sfi.1 uc292sfi.2 
ENSMUST00000190728.2 Gm28720 ENSMUST00000190728.2 Gm28720 (from geneSymbol) ENSMUST00000190728.1 uc291got.1 uc291got.2 uc291got.1 uc291got.2 
ENSMUST00000190734.3 Gm28778 ENSMUST00000190734.3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (from UniProt A0A087WSK7) A0A087WSK7 A0A087WSK7_MOUSE AK011265 ENSMUST00000190734.1 ENSMUST00000190734.2 Gm28778 uc287icj.1 uc287icj.2 uc287icj.3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. Reaction=adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA; Xref=Rhea:RHEA:37059, Rhea:RHEA-COMP:10162, Rhea:RHEA-COMP:10163, ChEBI:CHEBI:15378, ChEBI:CHEBI:73682, ChEBI:CHEBI:74411, ChEBI:CHEBI:74418, ChEBI:CHEBI:456215; EC=2.3.1.234; Evidence= Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 1 divalent metal cation per subunit. Ceramide-sensitive subunit of the serine palmitoyltransferase (SPT) complex, which is also composed of SPTLC1, SPTLC2/3 and SPTSSA/B. Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Mitochondrion Belongs to the KAE1 / TsaD family. Belongs to the ORM family. endoplasmic reticulum membrane ceramide metabolic process membrane integral component of membrane SPOTS complex negative regulation of sphingolipid biosynthetic process cellular sphingolipid homeostasis negative regulation of ceramide biosynthetic process uc287icj.1 uc287icj.2 uc287icj.3 
ENSMUST00000190739.2 A230060F14Rik ENSMUST00000190739.2 A230060F14Rik (from geneSymbol) AK038758 ENSMUST00000190739.1 uc287tth.1 uc287tth.2 uc287tth.1 uc287tth.2 
ENSMUST00000190743.2 Gm28336 ENSMUST00000190743.2 Gm28336 (from geneSymbol) ENSMUST00000190743.1 uc292tcq.1 uc292tcq.2 uc292tcq.1 uc292tcq.2 
ENSMUST00000190769.2 Gm28401 ENSMUST00000190769.2 Gm28401 (from geneSymbol) ENSMUST00000190769.1 uc287wtw.1 uc287wtw.2 uc287wtw.1 uc287wtw.2 
ENSMUST00000190777.2 Gm28444 ENSMUST00000190777.2 Gm28444 (from geneSymbol) ENSMUST00000190777.1 uc292sbg.1 uc292sbg.2 uc292sbg.1 uc292sbg.2 
ENSMUST00000190782.2 Gm20905 ENSMUST00000190782.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE BC100464 ENSMUST00000190782.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292tdn.1 uc292tdn.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292tdn.1 uc292tdn.2 
ENSMUST00000190806.7 Gm21861 ENSMUST00000190806.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRF5) 1700040F15Rik A0A087WRF5 A0A087WRF5_MOUSE AK077064 ENSMUST00000190806.1 ENSMUST00000190806.2 ENSMUST00000190806.3 ENSMUST00000190806.4 ENSMUST00000190806.5 ENSMUST00000190806.6 Gm20792 Gm20837 Gm20838 Gm21094 Gm21256 Gm21739 Gm21861 Gm28891 uc292tuv.1 uc292tuv.2 Belongs to the XLR/SYCP3 family. synaptonemal complex molecular_function spermatogenesis spermatid development meiotic cell cycle uc292tuv.1 uc292tuv.2 
ENSMUST00000190820.2 Gm29579 ENSMUST00000190820.2 Gm29579 (from geneSymbol) ENSMUST00000190820.1 uc292swh.1 uc292swh.2 uc292swh.1 uc292swh.2 
ENSMUST00000190821.2 Gm29067 ENSMUST00000190821.2 Gm29067 (from geneSymbol) ENSMUST00000190821.1 uc290mul.1 uc290mul.2 uc290mul.1 uc290mul.2 
ENSMUST00000190827.7 Vgf ENSMUST00000190827.7 [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (PubMed:19863797, PubMed:26180209, PubMed:30504797). (from UniProt Q0VGU4) BC085134 ENSMUST00000190827.1 ENSMUST00000190827.2 ENSMUST00000190827.3 ENSMUST00000190827.4 ENSMUST00000190827.5 ENSMUST00000190827.6 Q0VGU4 VGF_MOUSE Vgf uc057lof.1 uc057lof.2 [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (PubMed:19863797, PubMed:26180209, PubMed:30504797). [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Stimulates also feeding behavior in an orexin- dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity). [VGF-derived peptide TLQP-21]: Secreted multifunctional peptide that interacts with different receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation as well as lipolysis (PubMed:22289198, PubMed:25456411). Activates the G-protein- coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (PubMed:25456411). Interacts with gC1qR receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity). [VGF-derived peptide TLQP-62]: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (PubMed:26180209, PubMed:30504797). Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (PubMed:25917832). [VGF-derived peptide TLQP-21]: Interacts with HSPA8 on cell membrane (By similarity). Interacts with C3AR1 (PubMed:25456411). Interacts with C1QBP (By similarity). [Neurosecretory protein VGF]: Secreted Cytoplasmic vesicle, secretory vesicle Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus. VGF-deficiency produces a lean, hypermetabolic mouse that is resistant to diet and genetically-induced obesity. ovarian follicle development response to dietary excess neuropeptide hormone activity extracellular region extracellular space Golgi apparatus generation of precursor metabolites and energy signal transduction growth factor activity response to cold sexual reproduction insulin secretion transport vesicle secretory granule membrane cytoplasmic vesicle response to insulin glucose homeostasis defense response to bacterium neuron projection neuronal cell body penile erection intracellular membrane-bounded organelle synapse regulation of neuronal synaptic plasticity response to cAMP uc057lof.1 uc057lof.2 
ENSMUST00000190841.3 ENSMUSG00000121842 ENSMUST00000190841.3 ENSMUSG00000121842 (from geneSymbol) AK006445 ENSMUST00000190841.1 ENSMUST00000190841.2 uc012fgu.1 uc012fgu.2 uc012fgu.3 uc012fgu.4 uc012fgu.1 uc012fgu.2 uc012fgu.3 uc012fgu.4 
ENSMUST00000190845.2 Gm28793 ENSMUST00000190845.2 Gm28793 (from geneSymbol) ENSMUST00000190845.1 uc289xan.1 uc289xan.2 uc289xan.1 uc289xan.2 
ENSMUST00000190852.2 Gm29384 ENSMUST00000190852.2 Gm29384 (from geneSymbol) ENSMUST00000190852.1 uc292tbi.1 uc292tbi.2 uc292tbi.1 uc292tbi.2 
ENSMUST00000190863.2 Gm28981 ENSMUST00000190863.2 Gm28981 (from geneSymbol) AK042153 ENSMUST00000190863.1 uc287itp.1 uc287itp.2 uc287itp.1 uc287itp.2 
ENSMUST00000190865.2 Gm29050 ENSMUST00000190865.2 Gm29050 (from geneSymbol) AK139254 ENSMUST00000190865.1 uc289grs.1 uc289grs.2 uc289grs.1 uc289grs.2 
ENSMUST00000190867.2 Gm28633 ENSMUST00000190867.2 Gm28633 (from geneSymbol) ENSMUST00000190867.1 uc292ufk.1 uc292ufk.2 uc292ufk.1 uc292ufk.2 
ENSMUST00000190880.2 Gm20963 ENSMUST00000190880.2 Gm20963 (from geneSymbol) ENSMUST00000190880.1 uc292tul.1 uc292tul.2 uc292tul.1 uc292tul.2 
ENSMUST00000190887.2 Gm29446 ENSMUST00000190887.2 Gm29446 (from geneSymbol) ENSMUST00000190887.1 uc292ufg.1 uc292ufg.2 uc292ufg.1 uc292ufg.2 
ENSMUST00000190889.7 2010310C07Rik ENSMUST00000190889.7 RIKEN cDNA 2010310C07 gene (from RefSeq NR_045169.1) ENSMUST00000190889.1 ENSMUST00000190889.2 ENSMUST00000190889.3 ENSMUST00000190889.4 ENSMUST00000190889.5 ENSMUST00000190889.6 NR_045169 uc009bre.1 uc009bre.2 uc009bre.3 uc009bre.4 uc009bre.1 uc009bre.2 uc009bre.3 uc009bre.4 
ENSMUST00000190890.2 1700065D16Rik ENSMUST00000190890.2 1700065D16Rik (from geneSymbol) BC053441 ENSMUST00000190890.1 uc292jss.1 uc292jss.2 uc292jss.1 uc292jss.2 
ENSMUST00000190896.2 2410012E07Rik ENSMUST00000190896.2 RIKEN cDNA 2410012E07 gene (from RefSeq NR_045939.1) ENSMUST00000190896.1 NR_045939 uc029sls.1 uc029sls.2 uc029sls.1 uc029sls.2 
ENSMUST00000190898.2 Gm28112 ENSMUST00000190898.2 Gm28112 (from geneSymbol) ENSMUST00000190898.1 uc287izg.1 uc287izg.2 uc287izg.1 uc287izg.2 
ENSMUST00000190899.2 Gm28492 ENSMUST00000190899.2 Gm28492 (from geneSymbol) ENSMUST00000190899.1 uc289zjs.1 uc289zjs.2 uc289zjs.1 uc289zjs.2 
ENSMUST00000190901.3 1700063A18Rik ENSMUST00000190901.3 RIKEN cDNA 1700063A18 gene (from RefSeq NR_040467.1) ENSMUST00000190901.1 ENSMUST00000190901.2 NR_040467 uc029qsg.1 uc029qsg.2 uc029qsg.3 uc029qsg.1 uc029qsg.2 uc029qsg.3 
ENSMUST00000190909.2 Gm20795 ENSMUST00000190909.2 Belongs to the SPIN/STSY family. (from UniProt J3QP49) ENSMUST00000190909.1 Gm20795 Gm20836 Gm21660 J3QP49 J3QP49_MOUSE uc292tgm.1 uc292tgm.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292tgm.1 uc292tgm.2 
ENSMUST00000190910.2 Gm29107 ENSMUST00000190910.2 Gm29107 (from geneSymbol) ENSMUST00000190910.1 LF192586 uc287gvr.1 uc287gvr.2 uc287gvr.1 uc287gvr.2 
ENSMUST00000190911.2 Gm29367 ENSMUST00000190911.2 Gm29367 (from geneSymbol) AK158719 ENSMUST00000190911.1 uc290rks.1 uc290rks.2 uc290rks.1 uc290rks.2 
ENSMUST00000190914.2 Gm29622 ENSMUST00000190914.2 Gm29622 (from geneSymbol) ENSMUST00000190914.1 uc292tzg.1 uc292tzg.2 uc292tzg.1 uc292tzg.2 
ENSMUST00000190919.2 Gm28538 ENSMUST00000190919.2 Gm28538 (from geneSymbol) ENSMUST00000190919.1 uc292upz.1 uc292upz.2 uc292upz.1 uc292upz.2 
ENSMUST00000190930.4 2900093K20Rik ENSMUST00000190930.4 RIKEN cDNA 2900093K20 gene (from RefSeq NR_151490.1) ENSMUST00000190930.1 ENSMUST00000190930.2 ENSMUST00000190930.3 NR_151490 uc290cid.1 uc290cid.2 uc290cid.3 uc290cid.4 uc290cid.1 uc290cid.2 uc290cid.3 uc290cid.4 
ENSMUST00000190931.2 Gm29207 ENSMUST00000190931.2 Gm29207 (from geneSymbol) ENSMUST00000190931.1 uc292twk.1 uc292twk.2 uc292twk.1 uc292twk.2 
ENSMUST00000190932.7 Orly ENSMUST00000190932.7 oppositely-transcribed, rearranged locus on the Y, transcript variant 1 (from RefSeq NR_164355.1) ENSMUST00000190932.1 ENSMUST00000190932.2 ENSMUST00000190932.3 ENSMUST00000190932.4 ENSMUST00000190932.5 ENSMUST00000190932.6 NR_164355 uc292ucx.1 uc292ucx.2 uc292ucx.1 uc292ucx.2 
ENSMUST00000190938.2 Gm28198 ENSMUST00000190938.2 Gm28198 (from geneSymbol) ENSMUST00000190938.1 uc291vvr.1 uc291vvr.2 uc291vvr.1 uc291vvr.2 
ENSMUST00000190940.2 Dvl2 ENSMUST00000190940.2 Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. (from UniProt Q60838) BC092396 DVL2_MOUSE ENSMUST00000190940.1 Q60838 Q7TN14 uc287zms.1 uc287zms.2 Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex. Interacts with FAM105B/otulin. Interacts with DCDC2. Interacts (when phosphorylated) with FOXK1 and FOXK2; the interaction induces DVL2 nuclear translocation (By similarity). Interacts with MAPK15 (PubMed:25823377). Interacts with PKD1 (via extracellular domain) (PubMed:27214281). Interacts with LMBR1L (PubMed:31073040). Q60838; Q69ZU8-1: Ankrd6; NbExp=3; IntAct=EBI-641940, EBI-15605686; Q60838; Q8R4A3: Dact1; NbExp=3; IntAct=EBI-641940, EBI-3870250; Q60838; Q60838: Dvl2; NbExp=7; IntAct=EBI-641940, EBI-641940; Q60838; Q61062: Dvl3; NbExp=3; IntAct=EBI-641940, EBI-1538450; Q60838; Q80Z96: Vangl1; NbExp=4; IntAct=EBI-641940, EBI-1750708; Q60838; Q91ZD4: Vangl2; NbExp=4; IntAct=EBI-641940, EBI-1750744; Q60838; P84092: Ap2m1; Xeno; NbExp=4; IntAct=EBI-641940, EBI-297693; Q60838; P48730: CSNK1D; Xeno; NbExp=2; IntAct=EBI-641940, EBI-751621; Q60838; P49674: CSNK1E; Xeno; NbExp=3; IntAct=EBI-641940, EBI-749343; Q60838; Q9Y4D1-1: DAAM1; Xeno; NbExp=4; IntAct=EBI-641940, EBI-15677700; Q60838; Q155Q3: DIXDC1; Xeno; NbExp=4; IntAct=EBI-641940, EBI-1104700; Q60838; P53350: PLK1; Xeno; NbExp=12; IntAct=EBI-641940, EBI-476768; Q60838; Q9NZC7: WWOX; Xeno; NbExp=2; IntAct=EBI-641940, EBI-4320739; Cell membrane eripheral membrane protein ; Cytoplasmic side Cytoplasm, cytosol Cytoplasmic vesicle Nucleus Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization (PubMed:21189423). Localizes to cytoplasmic puncta. Interaction with FOXK1 and FOXK2 induces nuclear translocation (By similarity). Ubiquitous. The DIX domain mediates homooligomerization. Phosphorylated by CSNK1D (By similarity). WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases (By similarity). Belongs to the DSH family. neural tube closure positive regulation of protein phosphorylation heart morphogenesis outflow tract morphogenesis frizzled binding protein binding nucleus nucleoplasm cytoplasm cytosol cytoskeleton plasma membrane cell cortex transcription from RNA polymerase II promoter multicellular organism development segment specification heart development membrane Wnt signaling pathway aggresome lateral plasma membrane nuclear body protein kinase binding protein domain specific binding convergent extension involved in neural plate elongation clathrin-coated vesicle protein binding, bridging cytoplasmic vesicle cellular protein localization segmentation intracellular signal transduction non-canonical Wnt signaling pathway identical protein binding positive regulation of JUN kinase activity positive regulation of GTPase activity protein self-association canonical Wnt signaling pathway involved in regulation of cell proliferation apical part of cell positive regulation of transcription, DNA-templated Rac GTPase binding positive regulation of sequence-specific DNA binding transcription factor activity convergent extension involved in organogenesis canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway positive regulation of protein tyrosine kinase activity cochlea morphogenesis planar cell polarity pathway involved in neural tube closure uc287zms.1 uc287zms.2 
ENSMUST00000190946.7 Gm28490 ENSMUST00000190946.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRT9) A0A087WRT9 A0A087WRT9_MOUSE AK077064 ENSMUST00000190946.1 ENSMUST00000190946.2 ENSMUST00000190946.3 ENSMUST00000190946.4 ENSMUST00000190946.5 ENSMUST00000190946.6 Gm28490 Gm29582 uc292sxg.1 uc292sxg.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292sxg.1 uc292sxg.2 
ENSMUST00000190953.2 Gm29316 ENSMUST00000190953.2 Gm29316 (from geneSymbol) ENSMUST00000190953.1 FJ386436 uc292svr.1 uc292svr.2 uc292svr.1 uc292svr.2 
ENSMUST00000190957.7 Dop1a ENSMUST00000190957.7 DOP1 leucine zipper like protein A, transcript variant 1 (from RefSeq NM_177208.4) Dop1a Dopey1 ENSMUST00000190957.1 ENSMUST00000190957.2 ENSMUST00000190957.3 ENSMUST00000190957.4 ENSMUST00000190957.5 ENSMUST00000190957.6 H7BWZ9 H7BWZ9_MOUSE NM_177208 uc292jid.1 uc292jid.2 Belongs to the dopey family. cytosol Golgi to endosome transport uc292jid.1 uc292jid.2 
ENSMUST00000190962.7 Pik3c2g ENSMUST00000190962.7 Belongs to the PI3/PI4-kinase family. (from UniProt Q4FZD4) BC099684 ENSMUST00000190962.1 ENSMUST00000190962.2 ENSMUST00000190962.3 ENSMUST00000190962.4 ENSMUST00000190962.5 ENSMUST00000190962.6 Pik3c2g Q4FZD4 Q4FZD4_MOUSE uc291jxk.1 uc291jxk.2 Belongs to the PI3/PI4-kinase family. phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling uc291jxk.1 uc291jxk.2 
ENSMUST00000190968.2 ENSMUSG00000121320 ENSMUST00000190968.2 ENSMUSG00000121320 (from geneSymbol) BC100413 ENSMUST00000190968.1 uc029yel.1 uc029yel.2 uc029yel.3 uc029yel.1 uc029yel.2 uc029yel.3 
ENSMUST00000190974.2 Ppnr ENSMUST00000190974.2 Ppnr (from geneSymbol) AB064489 ENSMUST00000190974.1 uc289skz.1 uc289skz.2 uc289skz.1 uc289skz.2 
ENSMUST00000190980.3 4930532M18Rik ENSMUST00000190980.3 4930532M18Rik (from geneSymbol) AK015950 ENSMUST00000190980.1 ENSMUST00000190980.2 uc287mrw.1 uc287mrw.2 uc287mrw.3 uc287mrw.1 uc287mrw.2 uc287mrw.3 
ENSMUST00000190987.2 Gm20867 ENSMUST00000190987.2 predicted gene, 20867 (from RefSeq NM_001160142.2) ENSMUST00000190987.1 Gm20816 Gm20867 LOC382133 NM_001160142 Q5FWD4 Q5FWD4_MOUSE uc029yfy.1 uc029yfy.2 uc029yfy.3 uc029yfy.4 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc029yfy.1 uc029yfy.2 uc029yfy.3 uc029yfy.4 
ENSMUST00000190989.2 Gm28593 ENSMUST00000190989.2 Gm28593 (from geneSymbol) ENSMUST00000190989.1 uc292sau.1 uc292sau.2 uc292sau.1 uc292sau.2 
ENSMUST00000190994.2 Gm28726 ENSMUST00000190994.2 Gm28726 (from geneSymbol) ENSMUST00000190994.1 uc292tlo.1 uc292tlo.2 uc292tlo.1 uc292tlo.2 
ENSMUST00000190995.2 Ace3 ENSMUST00000190995.2 angiotensin I converting enzyme 3 (from RefSeq NM_001101453.3) ACE3_MOUSE Ace3 D0G895 ENSMUST00000190995.1 NM_001101453 uc011ygg.1 uc011ygg.2 uc011ygg.3 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Interacts with IZUMO1. Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Multi-pass membrane protein Note=Disappears from acrosome reacted sperm. Co- localizes with IZUMO1 at acrosomal cap area. Expressed in sperm and testis (at protein level) (PubMed:20421979). Expressed in heart and testis (PubMed:17597519). Not detected in kidney, lung, liver, brain, ovary, spleen and thymus (PubMed:17597519, PubMed:20421979). No visible phenotype. Sperm have normal fertilizing ability. Belongs to the peptidase M2 family. Lacks the conserved Glu residue in position 378 necessary for the catalytic activity. acrosomal vesicle acrosomal membrane regulation of systemic arterial blood pressure by renin-angiotensin positive regulation of systemic arterial blood pressure protein binding extracellular space plasma membrane proteolysis metallopeptidase activity exopeptidase activity dipeptidyl-peptidase activity peptidyl-dipeptidase activity membrane integral component of membrane cytoplasmic vesicle positive regulation of blood pressure uc011ygg.1 uc011ygg.2 uc011ygg.3 
ENSMUST00000190997.7 Rbbp5 ENSMUST00000190997.7 retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit, transcript variant 1 (from RefSeq NM_172517.2) ENSMUST00000190997.1 ENSMUST00000190997.2 ENSMUST00000190997.3 ENSMUST00000190997.4 ENSMUST00000190997.5 ENSMUST00000190997.6 NM_172517 Q3TBL4 Q3U3G1 Q6PAP0 Q6PFC2 Q8BX09 RBBP5_MOUSE uc007cox.1 uc007cox.2 uc007cox.3 uc007cox.4 In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (PubMed:21335234). Does not affect ES cell self-renewal (PubMed:21335234). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (By similarity). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity). Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (By similarity). Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7 (By similarity). Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin (By similarity). Component of a histone methylation complex composed of at least ZNF335, RBBP5, ASH2L and WDR5; the complex may have histone H3-specific methyltransferase activity, however does not have specificity for 'Lys-4' of histone H3 (By similarity). Interacts with ZNF335 (PubMed:23178126). Interacts with ASH2L; the interaction is direct (By similarity). Interacts with WDR5; the interaction is direct (By similarity). Components of the ZNF335- RBBP5-ASH2L-WDR5 histone methylation complex may associate with components of a nuclear receptor-mediated transcription complex to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5 (By similarity). Within this complex interacts with EMSY (By similarity). Found in a complex with RBBP5, ASH2L, DPY30, KMT2A, KMT2D and WDR5 (PubMed:21335234). Interacts with SETD1A (By similarity). Interacts with WDR82 (By similarity). Q8BX09; Q91X20: Ash2l; NbExp=10; IntAct=EBI-1556543, EBI-1556554; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BX09-1; Sequence=Displayed; Name=2; IsoId=Q8BX09-2; Sequence=VSP_038671, VSP_038672; protein binding nucleus nucleoplasm nucleolus chromatin organization cellular response to DNA damage stimulus methylated histone binding histone methyltransferase complex histone methyltransferase activity (H3-K4 specific) response to estrogen transcription regulatory region DNA binding MLL3/4 complex Set1C/COMPASS complex histone H3-K4 methylation MLL1 complex uc007cox.1 uc007cox.2 uc007cox.3 uc007cox.4 
ENSMUST00000191003.2 Gm28174 ENSMUST00000191003.2 Gm28174 (from geneSymbol) ENSMUST00000191003.1 uc292unm.1 uc292unm.2 uc292unm.1 uc292unm.2 
ENSMUST00000191007.2 Gm29359 ENSMUST00000191007.2 Gm29359 (from geneSymbol) ENSMUST00000191007.1 uc287lfv.1 uc287lfv.2 uc287lfv.1 uc287lfv.2 
ENSMUST00000191008.2 Gm29182 ENSMUST00000191008.2 Gm29182 (from geneSymbol) ENSMUST00000191008.1 uc292ukj.1 uc292ukj.2 uc292ukj.1 uc292ukj.2 
ENSMUST00000191011.7 Apbb1 ENSMUST00000191011.7 amyloid beta precursor protein binding family B member 1, transcript variant 2 (from RefSeq NM_009685.4) A0A0R4J2C6 A0A0R4J2C6_MOUSE Apbb1 ENSMUST00000191011.1 ENSMUST00000191011.2 ENSMUST00000191011.3 ENSMUST00000191011.4 ENSMUST00000191011.5 ENSMUST00000191011.6 NM_009685 uc009iyj.1 uc009iyj.2 uc009iyj.3 uc009iyj.4 beta-amyloid binding uc009iyj.1 uc009iyj.2 uc009iyj.3 uc009iyj.4 
ENSMUST00000191015.7 Gm29130 ENSMUST00000191015.7 Gm29130 (from geneSymbol) DQ874391 ENSMUST00000191015.1 ENSMUST00000191015.2 ENSMUST00000191015.3 ENSMUST00000191015.4 ENSMUST00000191015.5 ENSMUST00000191015.6 uc292tvm.1 uc292tvm.2 uc292tvm.1 uc292tvm.2 
ENSMUST00000191029.2 1700066C05Rik ENSMUST00000191029.2 RIKEN cDNA 1700066C05 gene (from RefSeq NR_169071.1) ENSMUST00000191029.1 NR_169071 uc289fqx.1 uc289fqx.2 uc289fqx.1 uc289fqx.2 
ENSMUST00000191031.2 Gm28430 ENSMUST00000191031.2 Gm28430 (from geneSymbol) ENSMUST00000191031.1 uc292sas.1 uc292sas.2 uc292sas.1 uc292sas.2 
ENSMUST00000191034.2 Gm29103 ENSMUST00000191034.2 Gm29103 (from geneSymbol) AK035428 ENSMUST00000191034.1 uc287lqd.1 uc287lqd.2 uc287lqd.1 uc287lqd.2 
ENSMUST00000191038.3 1700120K04Rik ENSMUST00000191038.3 RIKEN cDNA 1700120K04 gene (from RefSeq NR_027915.1) ENSMUST00000191038.1 ENSMUST00000191038.2 NR_027915 uc009jwf.1 uc009jwf.2 uc009jwf.3 uc009jwf.4 uc009jwf.5 uc009jwf.1 uc009jwf.2 uc009jwf.3 uc009jwf.4 uc009jwf.5 
ENSMUST00000191045.2 Gm29506 ENSMUST00000191045.2 Gm29506 (from geneSymbol) AK046640 ENSMUST00000191045.1 uc287gvm.1 uc287gvm.2 uc287gvm.1 uc287gvm.2 
ENSMUST00000191046.7 Epb41l5 ENSMUST00000191046.7 erythrocyte membrane protein band 4.1 like 5, transcript variant 2 (from RefSeq NM_001113416.1) E41L5_MOUSE ENSMUST00000191046.1 ENSMUST00000191046.2 ENSMUST00000191046.3 ENSMUST00000191046.4 ENSMUST00000191046.5 ENSMUST00000191046.6 Epb4.1l5 Kiaa1548 NM_001113416 Q3TJG0 Q69ZG8 Q8BGS1 Q8BSC9 Q99KZ8 uc007ciy.1 uc007ciy.2 uc007ciy.3 uc007ciy.4 Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. Component of a complex composed of PALS1, CRB1 and EPB41L5 (By similarity). Within the complex, interacts (via FERM domain) with PALS1 (via HOOK domain) and with CRB1 (via intracellular domain) (By similarity). Interacts with CRB2 (via intracellular domain) (By similarity). Interacts with CRB3 (via intracellular domain) (By similarity). Cytoplasm Cell junction, adherens junction Cell membrane ; Peripheral membrane protein Photoreceptor inner segment Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BGS1-1; Sequence=Displayed; Name=2; IsoId=Q8BGS1-2; Sequence=VSP_033040, VSP_033041; Name=3; IsoId=Q8BGS1-3; Sequence=VSP_033039; In the retina, expressed at the outer limiting membrane, retinal pigment epithelium, outer nuclear layer and outer plexiform layer (at protein level) (PubMed:17920587). Also detected in the inner segments (at protein level) (PubMed:17920587). Expressed at the basolateral and apical sides of the mesonephric tubules in the kidney (at protein level) (PubMed:17920587). At 10.5 dpc, strongly expressed in the developing neural tube and optic vesicle, as well as in the branchial arches and kidney (PubMed:17920587). In the developing kidney, detected in the mesonephrotic tubules (PubMed:17920587). At 11.5 dpc, expressed along the entire cranial-caudal length of the developing neural tube, including the anterior forebrain and the posterior spinal cord (PubMed:17920587). Always restricted to the ventricular layer, where proliferative cells are located (PubMed:17920587). Conversely, not detected in postmitotic neural compartments (PubMed:17920587). In the developing lung, at 11.5 dpc, expressed in the internal endodermal layer and in particular in the nascent bronchial tips (PubMed:17920587). At 12.5 dpc, expressed in the optic vesicle, detected mainly in the retinal layer (PubMed:17920587). The retinal pigment epithelium shows only background levels (PubMed:17920587). At 15.5 dpc expressed at the basolateral side of the plasma membrane in brain, spinal cord, kidney, testis, intestine, skin, and muscles (PubMed:17920587). Sequence=BAD32476.1; Type=Erroneous initiation; Evidence=; cell morphogenesis involved in differentiation in utero embryonic development somitogenesis epithelial to mesenchymal transition neural plate morphogenesis positive regulation of cell-matrix adhesion epithelial cell morphogenesis apical constriction protein binding nucleus cytoplasm cytosol cytoskeleton plasma membrane adherens junction focal adhesion substrate-dependent cell migration, cell attachment to substrate ectoderm development endoderm development mesoderm development mesoderm migration involved in gastrulation cytoskeletal protein binding unidimensional cell growth posttranscriptional regulation of gene expression positive regulation of epithelial cell migration protein domain specific binding negative regulation of cell-cell adhesion actin cytoskeleton organization cell junction actomyosin structure organization cell leading edge negative regulation of protein binding positive regulation of protein binding somite rostral/caudal axis specification ruffle membrane axial mesoderm development axial mesoderm morphogenesis paraxial mesoderm development embryonic foregut morphogenesis positive regulation of focal adhesion assembly regulation of establishment of protein localization left/right axis specification cellular response to transforming growth factor beta stimulus uc007ciy.1 uc007ciy.2 uc007ciy.3 uc007ciy.4 
ENSMUST00000191052.2 Gm29351 ENSMUST00000191052.2 Gm29351 (from geneSymbol) ENSMUST00000191052.1 FJ386436 uc292rzg.1 uc292rzg.2 uc292rzg.1 uc292rzg.2 
ENSMUST00000191054.2 Gm29305 ENSMUST00000191054.2 Gm29305 (from geneSymbol) ENSMUST00000191054.1 uc292trd.1 uc292trd.2 uc292trd.1 uc292trd.2 
ENSMUST00000191057.3 Gm28756 ENSMUST00000191057.3 Gm28756 (from geneSymbol) ENSMUST00000191057.1 ENSMUST00000191057.2 uc287gsn.1 uc287gsn.2 uc287gsn.3 uc287gsn.1 uc287gsn.2 uc287gsn.3 
ENSMUST00000191067.2 5930403N24Rik ENSMUST00000191067.2 RIKEN cDNA 5930403N24 gene, transcript variant 2 (from RefSeq NR_166104.1) ENSMUST00000191067.1 NR_166104 uc007evi.1 uc007evi.2 uc007evi.1 uc007evi.2 
ENSMUST00000191071.7 Gm28987 ENSMUST00000191071.7 Gm28987 (from geneSymbol) ENSMUST00000191071.1 ENSMUST00000191071.2 ENSMUST00000191071.3 ENSMUST00000191071.4 ENSMUST00000191071.5 ENSMUST00000191071.6 uc292suy.1 uc292suy.2 uc292suy.1 uc292suy.2 
ENSMUST00000191073.3 Gm10668 ENSMUST00000191073.3 predicted gene 10668 (from RefSeq NM_001370900.1) EG381936 ENSMUST00000191073.1 ENSMUST00000191073.2 Gm10668 Gm4567 Gm6902 NM_001370900 Q3UTA8 Q3UTA8_MOUSE uc057ltf.1 uc057ltf.2 uc057ltf.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. nucleotide binding microtubule cytoskeleton organization molecular_function protein kinase activity protein serine/threonine kinase activity ATP binding cellular_component cytoplasm protein phosphorylation biological_process intracellular signal transduction tau-protein kinase activity uc057ltf.1 uc057ltf.2 uc057ltf.3 
ENSMUST00000191077.2 Gm29466 ENSMUST00000191077.2 Gm29466 (from geneSymbol) ENSMUST00000191077.1 uc292tuh.1 uc292tuh.2 uc292tuh.1 uc292tuh.2 
ENSMUST00000191081.7 Mag ENSMUST00000191081.7 myelin-associated glycoprotein, transcript variant 9 (from RefSeq NM_001416848.1) A0A087WPR1 ENSMUST00000191081.1 ENSMUST00000191081.2 ENSMUST00000191081.3 ENSMUST00000191081.4 ENSMUST00000191081.5 ENSMUST00000191081.6 MAG_MOUSE NM_001416848 P16880 P20917 uc009gha.1 uc009gha.2 uc009gha.3 Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid- containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (PubMed:7533044, PubMed:12089450, PubMed:27922006). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination (PubMed:7516497, PubMed:9262180, PubMed:9482781, PubMed:9482783, PubMed:9469574, PubMed:10625334). Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2 (PubMed:26335717). Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (PubMed:15953602, PubMed:19158290). Negative regulator of neurite outgrowth that inhibits axon longitudinal growth (PubMed:19158290, PubMed:27922006, PubMed:12089450). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides (PubMed:17640868). In cerebellar granule cells the inhibition is mediated via binding to neuronal gangliosides (PubMed:17640868). In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides (By similarity). Inhibits axon outgrowth by binding to RTN4R (PubMed:12089450). Preferentially binds to alpha-2,3-linked sialic acid (PubMed:7533044, PubMed:27922006). Binds ganglioside Gt1b (PubMed:27922006). Monomer and homodimer (PubMed:27922006). Interacts (via the first three N-terminal Ig-like domains) with RTN4R and RTN4RL2 (PubMed:12089450, PubMed:26335717). Interacts with isoform 2 of BSG (PubMed:12558975). Cell membrane ingle-pass type I membrane protein Membrane raft Event=Alternative splicing; Named isoforms=2; Name=L-MAG; IsoId=P20917-1; Sequence=Displayed; Name=S-MAG; IsoId=P20917-2; Sequence=VSP_002527, VSP_002528; Detected in the myelin tract in brain, especially in the corpus callosum and in peripheral nerve (PubMed:7516497, PubMed:9482783, PubMed:24191038). Expressed by myelinating glial cells in the central and peripheral nervous system (PubMed:10625334). Detected in oligodendrocyte processes before formation of compact myelin (PubMed:2474006, PubMed:10625334). Restricted to the periaxonal space after myelination (PubMed:10625334). Isoform S-MAG is the predominant isoform in CNS and PNS of the adult (at protein level) (PubMed:1716323). In CNS isoform L-MAG is the major form synthesized early in development, and it persists as a significant proportion of the MAG present in the adult. In the PNS isoform L-MAG is expressed at modest levels during development; it is absent in the adult. The C-terminal cytoplasmic region found only in isoform L-MAG is required for normal myelination in the central nervous system (CNS), but is apparently not required for normal myelination in the peripheral nervous system (PNS). The extracellular domain is required to protect against axon degeneration (PubMed:19158290, PubMed:26335717). The first three Ig- like domains mediate interaction with RTN4R and RTN4RL2, but are not sufficient to inhibit neurite outgrowth (By similarity). The two C- terminal extracellular Ig-like C2-type domains are required for inhibition of axon longitudinal growth. Besides, the two C-terminal extracellular Ig-like C2-type domains are required for protection against apoptosis after nerve injury (PubMed:26335717). N-glycosylated. Phosphorylated on tyrosine residues. Ubiquitinated, leading to proteasomal degradation. Mutant mice appear normal, excepting subtle defects in motor coordination and a slight intention tremor (PubMed:7516497). They have similar numbers of motoneurons as wild-type at birth, but display an important loss of motoneurons during the first week after birth (PubMed:26335717).Five month old mutant mice display a decreased ability to remain on a rotating cylinder (PubMed:15953602). Contrary to wild-type, about 40% of mutant mice have severe episodes of whole-body tremor, both during movement and when resting (PubMed:15953602). The myelination in brain and around peripheral nerves appears grossly normal in young animals, but the periaxonal cytoplasmic collar is often missing in optic nerve (PubMed:7516497, PubMed:9262180, PubMed:9482781, PubMed:9469574). When present, the cytoplasm of the periaxonal collar has generally a disorganized aspect (PubMed:7516497). Mutant mice have an increased percentage of unmyelinated axons in optic nerve (PubMed:9262180, PubMed:9469574). Besides, a small proportion of nerves from mutant mice display redundant myelination, and also rare cases of multiple myelination, where axons are surrounded by two or more compact myelin sheets (PubMed:9469574). Sciatic nerves from over three month old mutant mice show signs of Wallerian degeneration, with redundant myelin, degeneration of myelinated fibers, and an apparent decrease in the diameter of myelinated axons (PubMed:9482781, PubMed:15953602). The distances between neurofilaments in myelinated axons from over 3 month old mice are shorter than normal (PubMed:9482781, PubMed:15953602). With increasing age, mutant mice display progressive axon degeneration in the spinal cord and sciatic nerve, resulting in a decrease of 28% in the number of spinal cord axons after 15 months (PubMed:19158290). Mutant mice display increased motoneuron apoptosis after injury (PubMed:26335717). Likewise, they display strongly increased axon degeneration after treatment with the neurotoxin acrylamide (PubMed:19158290). Mutant mice display much more severe axon loss in response to experimental autoimmune encephalitis (PubMed:19158290). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Name=Functional Glycomics Gateway - Glycan Binding; Note=Siglec-4; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Itlect_196"; Name=Functional Glycomics Gateway - Glycan Binding; Note=Siglec-4a [3 Fc Domains]; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Itlect_00003"; receptor binding protein binding cytoplasm plasma membrane integral component of plasma membrane cell adhesion nervous system development lipid binding negative regulation of neuron projection development membrane integral component of membrane transmission of nerve impulse protein kinase binding central nervous system myelination carbohydrate binding negative regulation of axon extension axon regeneration positive regulation of myelination paranode region of axon sialic acid binding myelin sheath adaxonal region protein homodimerization activity myelin sheath compact myelin Schmidt-Lanterman incisure negative regulation of neuron apoptotic process membrane raft negative regulation of neuron differentiation positive regulation of astrocyte differentiation cellular response to mechanical stimulus mesaxon cell-cell adhesion via plasma-membrane adhesion molecules ganglioside GT1b binding uc009gha.1 uc009gha.2 uc009gha.3 
ENSMUST00000191085.7 Gm28463 ENSMUST00000191085.7 Gm28463 (from geneSymbol) ENSMUST00000191085.1 ENSMUST00000191085.2 ENSMUST00000191085.3 ENSMUST00000191085.4 ENSMUST00000191085.5 ENSMUST00000191085.6 uc292tbv.1 uc292tbv.2 uc292tbv.1 uc292tbv.2 
ENSMUST00000191087.2 Gm28634 ENSMUST00000191087.2 Gm28634 (from geneSymbol) ENSMUST00000191087.1 uc287hql.1 uc287hql.2 uc287hql.1 uc287hql.2 
ENSMUST00000191089.2 Gm49416 ENSMUST00000191089.2 Gm49416 (from geneSymbol) A0A087WRC2 A0A087WRC2_MOUSE AK172260 ENSMUST00000191089.1 Gm49416 uc289qui.1 uc289qui.2 uc289qui.1 uc289qui.2 
ENSMUST00000191096.2 Gm28675 ENSMUST00000191096.2 Gm28675 (from geneSymbol) ENSMUST00000191096.1 uc289xiw.1 uc289xiw.2 uc289xiw.1 uc289xiw.2 
ENSMUST00000191098.2 Gm28970 ENSMUST00000191098.2 Gm28970 (from geneSymbol) ENSMUST00000191098.1 uc292uvz.1 uc292uvz.2 uc292uvz.1 uc292uvz.2 
ENSMUST00000191099.2 Gm28124 ENSMUST00000191099.2 Gm28124 (from geneSymbol) ENSMUST00000191099.1 uc292utf.1 uc292utf.2 uc292utf.1 uc292utf.2 
ENSMUST00000191102.2 Gm28331 ENSMUST00000191102.2 Gm28331 (from geneSymbol) ENSMUST00000191102.1 uc292sdj.1 uc292sdj.2 uc292sdj.1 uc292sdj.2 
ENSMUST00000191104.7 Tns1 ENSMUST00000191104.7 tensin 1, transcript variant 2 (from RefSeq NM_001289895.2) A0A087WQS0 A0A087WQS0_MOUSE ENSMUST00000191104.1 ENSMUST00000191104.2 ENSMUST00000191104.3 ENSMUST00000191104.4 ENSMUST00000191104.5 ENSMUST00000191104.6 NM_001289895 Tns1 uc007blg.1 uc007blg.2 uc007blg.3 uc007blg.4 uc007blg.5 Cell junction, focal adhesion Belongs to the PTEN phosphatase protein family. actin binding focal adhesion cell-substrate junction assembly fibroblast migration cell-substrate junction intracellular signal transduction uc007blg.1 uc007blg.2 uc007blg.3 uc007blg.4 uc007blg.5 
ENSMUST00000191112.2 Gm13283 ENSMUST00000191112.2 predicted gene 13283 (from RefSeq NM_001085531.2) A0A087WPG5 A0A087WPG5_MOUSE ENSMUST00000191112.1 Gm13283 If1ha2 NM_001085531 uc029uwt.1 uc029uwt.2 uc029uwt.3 Belongs to the alpha/beta interferon family. adaptive immune response T cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine receptor binding type I interferon receptor binding extracellular region extracellular space defense response humoral immune response cytokine-mediated signaling pathway B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein B cell proliferation response to exogenous dsRNA defense response to virus uc029uwt.1 uc029uwt.2 uc029uwt.3 
ENSMUST00000191121.2 Gm29129 ENSMUST00000191121.2 Gm29129 (from geneSymbol) ENSMUST00000191121.1 uc291opa.1 uc291opa.2 uc291opa.1 uc291opa.2 
ENSMUST00000191123.2 Gm20817 ENSMUST00000191123.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK3) A0A087WRK3 A0A087WRK3_MOUSE BC100464 ENSMUST00000191123.1 Gm20817 Gm21173 Gm21497 Gm28553 uc292ufj.1 uc292ufj.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292ufj.1 uc292ufj.2 
ENSMUST00000191124.7 Prkn ENSMUST00000191124.7 parkin RBR E3 ubiquitin protein ligase, transcript variant 1 (from RefSeq NM_016694.5) ENSMUST00000191124.1 ENSMUST00000191124.2 ENSMUST00000191124.3 ENSMUST00000191124.4 ENSMUST00000191124.5 ENSMUST00000191124.6 NM_016694 PRKN_MOUSE Park2 Prkn Q2KHJ9 Q9ES22 Q9ES23 Q9WVS6 uc008akk.1 uc008akk.2 uc008akk.3 uc008akk.4 Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:32047033, PubMed:29311685). Substrates include SYT11 and VDAC1 (PubMed:32047033, PubMed:29311685). Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (By similarity). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:32047033, PubMed:25474007). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (By similarity). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (By similarity). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (By similarity). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:32047033, PubMed:25474007, PubMed:22082830, PubMed:24898855). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:32047033, PubMed:22082830, PubMed:24898855). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:25474007). After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:21753002). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (By similarity). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:24192653). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (By similarity). Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (By similarity). Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (By similarity). Limits the production of reactive oxygen species (ROS) (By similarity). Regulates cyclin-E during neuronal apoptosis (By similarity). In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (By similarity). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene (By similarity). Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence=; In the autoinhibited state the side chain of Phe- 462 inserts into a hydrophobic groove in RING-0, occluding the ubiquitin acceptor site Cys-430, whereas the REP repressor element binds RING-1 and blocks its E2-binding site. Activation of PRKN requires 2 steps: (1) phosphorylation at Ser-65 by PINK1 and (2) binding to phosphorylated ubiquitin, leading to unlock repression of the catalytic Cys-430 by the RING-0 region via an allosteric mechanism and converting PRKN to its fully-active form. According to another report, phosphorylation at Ser-65 by PINK1 is not essential for activation and only binding to phosphorylated ubiquitin is essential to unlock repression. In addition, ISG15 conjugation positively regulates its ubiquitin E3 ligase activity by suppressing the intramolecular interaction that maintains its autoinhibited conformation. Protein modification; protein ubiquitination. Forms an E3 ubiquitin ligase complex with UBE2L3 or UBE2L6. Mediates 'Lys-63'-linked polyubiquitination by associating with UBE2V1. Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7. Interacts with SNCAIP. Binds to the C2A and C2B domains of SYT11. Interacts and regulates the turnover of SEPTIN5. Part of a complex, including STUB1, HSP70 and GPR37. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PRKN and GPR37, thus facilitating PRKN-mediated GPR37 ubiquitination. HSP70 transiently associates with unfolded GPR37 and inhibits the E3 activity of PRKN, whereas, STUB1 enhances the E3 activity of PRKN through promotion of dissociation of HSP70 from PRKN- GPR37 complexes. Interacts with PSMD4 and PACRG. Interacts with LRRK2. Interacts with RANBP2. Interacts with SUMO1 but not SUMO2, which promotes nuclear localization and autoubiquitination. Interacts (via first RING-type domain) with AIMP2 (via N-terminus). Interacts with PSMA7 and RNF41. Interacts with PINK1. Forms a complex with PINK1 and PARK7. Interacts with CHPF, the interaction with isoform 2 may facilitate PRKN transport into the mitochondria. Interacts with MFN2 (phosphorylated), promotes PRKN localization in dysfunctional depolarized mitochondria. Interacts with FBXO7; this promotes translocation to dysfunctional depolarized mitochondria. Interacts with ZNF746. Interacts with heat shock protein 70 family members, including HSPA1L, HSPA1A and HSPA8; interaction HSPA1L promotes translocation to damaged mitochondria. Interacts with BAG4 and, to a lesser extent, BAG5; interaction with BAG4 inhibits translocation to damaged mitochondria. Forms a complex with PRKN and PARK7 (By similarity). Interacts with AMBRA1 (PubMed:21753002). Q9WVS6; Q6IQX7-2: Chpf; NbExp=3; IntAct=EBI-973635, EBI-9029659; Q9WVS6; P47811: Mapk14; NbExp=3; IntAct=EBI-973635, EBI-298727; Q9WVS6; Q9ERU9: Ranbp2; NbExp=2; IntAct=EBI-973635, EBI-643756; Q9WVS6; P68510: Ywhah; NbExp=2; IntAct=EBI-973635, EBI-444641; Q9WVS6; Q3U133: Znf746; NbExp=2; IntAct=EBI-973635, EBI-3862590; Cytoplasm, cytosol cleus Endoplasmic reticulum Mitochondrion Mitochondrion outer membrane Cell projection, neuron projection Postsynaptic density Presynapse Note=Mainly localizes in the cytosol. Co-localizes with SYT11 in neutrites. Co-localizes with SNCAIP in brainstem Lewy bodies. Translocates to dysfunctional mitochondria that have lost the mitochondrial membrane potential; recruitment to mitochondria is PINK1-dependent. Mitochondrial localization also gradually increases with cellular growth. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9WVS6-1; Sequence=Displayed; Name=2; IsoId=Q9WVS6-2; Sequence=VSP_011714, VSP_011715; Name=3; IsoId=Q9WVS6-3; Sequence=VSP_011713, VSP_011716; Expressed in all subdivisions of the brain (at protein level) (PubMed:11675120). Highly expressed in brainstem, cranial nerve, pontine, cerebellar nuclei, indusium griseum, nuclei reticularis, strata oriens and laccunosum moleculare of the hippocampal CA2 region (PubMed:11122330). Low levels were found in the telencephalon and diencephalon (PubMed:11122330). Expressed in heart, liver, skeletal muscle, kidney and testis (PubMed:10818204). In late 10 dpc weakly expressed in postmitotic neurons in the mantle layer of the developing nervous system (at protein level). Expression increased at 11-12 dpc (at protein level). At 15-16 dpc, as more specialized neurons and nonneural cells are formed, expression is more tissue specific (at protein level). Expression was highest in the neurites, moderate levels were observed in the migrating postmitotic neurons in the intermediate and neopallial layers (at protein level). In the diencephalon and other CNS regions, while the weakest level of expression was observed in the cell bodies (at protein level). In nonneural tissues, high levels of expression were found in the muscle walls of the intestine, the blood vessels and the dermis (at protein level). The ubiquitin-like domain binds the PSMD4 subunit of 26S proteasomes. The RING-type 1 zinc finger domain is required to repress p53/TP53 transcription. Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT- type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain. Auto-ubiquitinates in an E2-dependent manner leading to its own degradation. Also polyubiquitinated by RNF41 for proteasomal degradation. S-nitrosylated. Phosphorylated. Activation requires phosphorylation at Ser-65 by PINK1 and binding to PINK1 phosphorylated ubiquitin. Phosphorylation at Thr-174 by PINK1 and at Thr-216 is important for mitochondrial localization. In brain, increased protein levels of p53/TP53 and CHPF (PubMed:19801972, PubMed:22082830). Cortical neurons display a slight increase in process fragmentation but no dendritic retraction (PubMed:24898855). Belongs to the RBR family. Parkin subfamily. negative regulation of transcription from RNA polymerase II promoter Golgi membrane ubiquitin ligase complex protein polyubiquitination mitochondrial fission mitophagy macromitophagy transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding G-protein coupled receptor binding negative regulation of protein phosphorylation synaptic transmission, dopaminergic startle response actin binding ubiquitin-protein transferase activity protein binding nucleus cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol plasma membrane ubiquitin-dependent protein catabolic process protein monoubiquitination autophagy response to oxidative stress mitochondrion organization learning locomotory behavior beta-catenin binding synaptic vesicle adult locomotory behavior regulation of gene expression proteasomal protein catabolic process regulation of autophagy positive regulation of gene expression negative regulation of gene expression positive regulation of mitochondrial fusion negative regulation of mitochondrial fusion regulation of mitochondrion organization positive regulation of mitochondrial membrane potential free ubiquitin chain polymerization postsynaptic density tubulin binding membrane aggresome protein ubiquitination nuclear speck transferase activity protein metabolic process enzyme binding kinase binding protein kinase binding cell junction PDZ domain binding axon dendrite Hsp70 protein binding synaptic vesicle membrane heat shock protein binding regulation of protein ubiquitination cytoplasmic vesicle ubiquitin conjugating enzyme binding ubiquitin protein ligase binding regulation of protein stability protein destabilization positive regulation of protein binding negative regulation of actin filament bundle assembly positive regulation of proteasomal ubiquitin-dependent protein catabolic process macromolecular complex negative regulation of glucokinase activity response to endoplasmic reticulum stress synaptic transmission, glutamatergic positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of dopamine metabolic process norepinephrine metabolic process dopamine metabolic process identical protein binding histone deacetylase binding regulation of apoptotic process cell projection neuron projection neuronal cell body positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process terminal bouton phospholipase binding positive regulation of DNA binding negative regulation of neuron apoptotic process mitochondrial fragmentation involved in apoptotic process cellular protein catabolic process negative regulation by host of viral genome replication macromolecular complex binding membrane raft synapse postsynaptic membrane positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of insulin secretion metal ion binding regulation of neurotransmitter secretion perinuclear region of cytoplasm modulation of synaptic transmission protein stabilization chaperone binding positive regulation of neurotransmitter uptake dopamine uptake involved in synaptic transmission mitochondrion localization protein autoubiquitination regulation of mitochondrial membrane potential negative regulation of synaptic transmission, glutamatergic zinc ion homeostasis negative regulation of cell death ubiquitin protein ligase activity parkin-mediated mitophagy in response to mitochondrial depolarization neuron cellular homeostasis protein K63-linked ubiquitination protein localization to mitochondrion aggresome assembly protein K48-linked ubiquitination protein K11-linked ubiquitination protein K6-linked ubiquitination negative regulation of canonical Wnt signaling pathway positive regulation of mitochondrial fission negative regulation of release of cytochrome c from mitochondria negative regulation of mitochondrial fission negative regulation of excitatory postsynaptic potential cellular response to toxic substance cullin family protein binding intracellular vesicle mitophagy in response to mitochondrial depolarization presynapse mitochondrion-derived vesicle mitochondrion to lysosome transport regulation of cellular response to oxidative stress negative regulation of neuron death positive regulation of macromitophagy positive regulation of proteasomal protein catabolic process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of primary amine oxidase activity positive regulation of protein linear polyubiquitination negative regulation of oxidative stress-induced neuron death positive regulation of tumor necrosis factor-mediated signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of reactive oxygen species biosynthetic process negative regulation of exosomal secretion positive regulation of mitophagy positive regulation of dendrite extension negative regulation of spontaneous neurotransmitter secretion cellular response to hydrogen sulfide cellular response to L-glutamate negative regulation of intralumenal vesicle formation positive regulation of protein localization to membrane ubiquitin-specific protease binding F-box domain binding Parkin-FBXW7-Cul1 ubiquitin ligase complex regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process positive regulation of ATP biosynthetic process uc008akk.1 uc008akk.2 uc008akk.3 uc008akk.4 
ENSMUST00000191125.2 Gm29664 ENSMUST00000191125.2 Gm29664 (from geneSymbol) ENSMUST00000191125.1 uc287hqs.1 uc287hqs.2 uc287hqs.1 uc287hqs.2 
ENSMUST00000191136.2 Gm28310 ENSMUST00000191136.2 Gm28310 (from geneSymbol) ENSMUST00000191136.1 uc292ths.1 uc292ths.2 uc292ths.1 uc292ths.2 
ENSMUST00000191138.7 Hivep2 ENSMUST00000191138.7 human immunodeficiency virus type I enhancer binding protein 2, transcript variant 2 (from RefSeq NM_001358782.1) ENSMUST00000191138.1 ENSMUST00000191138.2 ENSMUST00000191138.3 ENSMUST00000191138.4 ENSMUST00000191138.5 ENSMUST00000191138.6 Mibp1 NM_001358782 O55140 Q3UHF7 Q3UVD4 Q3UVH5 ZEP2_MOUSE uc007elj.1 uc007elj.2 uc007elj.3 Specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation (By similarity). Interacts with TCF4. Nucleus. Expressed in heart, lung, skeletal muscle and liver. In the brain expressed in cerebral cortex, hippocampus, corpora amygdala and cerebellar cortex. At 13.5 dpc and 15.5 dpc expressed in anterior neural tube over primordial frontal cortex, spinal cord, dorsal root glanglia and developing skeletal muscle. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor complex transcription, DNA-templated signal transduction positive regulation of transcription from RNA polymerase II promoter metal ion binding uc007elj.1 uc007elj.2 uc007elj.3 
ENSMUST00000191139.2 Gm4319 ENSMUST00000191139.2 Gm4319 (from geneSymbol) AK076447 ENSMUST00000191139.1 uc287jba.1 uc287jba.2 uc287jba.1 uc287jba.2 
ENSMUST00000191142.7 Nop58 ENSMUST00000191142.7 NOP58 ribonucleoprotein, transcript variant 1 (from RefSeq NM_018868.3) ENSMUST00000191142.1 ENSMUST00000191142.2 ENSMUST00000191142.3 ENSMUST00000191142.4 ENSMUST00000191142.5 ENSMUST00000191142.6 NM_018868 NOP58_MOUSE Nol5 O70396 Q3UYX9 Q3UZA3 Q6DFW4 Q8C8Y7 uc007bdy.1 uc007bdy.2 uc007bdy.3 Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA (PubMed:10864044). Interacts with NOLC1/Nopp140. Interacts with NOPCHAP1, NUFIP1, RUVBL1 and RUVBL2; NOPCHAP1 bridges the association of NOP58 with RUVBL1:RUVBL2 and NUFIP1. Interacts with PIH1D1. Nucleus, nucleolus Nucleus, nucleoplasm Note=Localizes to the nucleolus with a minor part present in the nucleoplasm. Sumoylation is essential for high-affinity binding to snoRNAs. Belongs to the NOP5/NOP56 family. Sequence=AAC08435.1; Type=Frameshift; Evidence=; TFIID-class transcription factor binding fibrillar center nucleus nucleoplasm nucleolus small nucleolar ribonucleoprotein complex cytosol Cajal body snoRNA binding box C/D snoRNP complex small-subunit processome ribosome biogenesis snoRNA localization ATPase binding pre-snoRNP complex uc007bdy.1 uc007bdy.2 uc007bdy.3 
ENSMUST00000191146.2 Gm29646 ENSMUST00000191146.2 Gm29646 (from geneSymbol) ENSMUST00000191146.1 uc292tjm.1 uc292tjm.2 uc292tjm.1 uc292tjm.2 
ENSMUST00000191155.2 1700069B07Rik ENSMUST00000191155.2 1700069B07Rik (from geneSymbol) AK006919 ENSMUST00000191155.1 uc291vco.1 uc291vco.2 uc291vco.1 uc291vco.2 
ENSMUST00000191156.2 Gm816 ENSMUST00000191156.2 predicted gene 816 (from RefSeq NR_188937.1) ENSMUST00000191156.1 NR_188937 uc287jnp.1 uc287jnp.2 uc287jnp.1 uc287jnp.2 
ENSMUST00000191165.2 Gm20987 ENSMUST00000191165.2 Gm20987 (from geneSymbol) ENSMUST00000191165.1 uc292twh.1 uc292twh.2 uc292twh.1 uc292twh.2 
ENSMUST00000191166.2 Gm29020 ENSMUST00000191166.2 Gm29020 (from geneSymbol) ENSMUST00000191166.1 uc287mki.1 uc287mki.2 uc287mki.1 uc287mki.2 
ENSMUST00000191169.2 Gm6902 ENSMUST00000191169.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; (from UniProt Q3UTA8) BC147388 EG381936 ENSMUST00000191169.1 Gm10668 Gm4567 Gm6902 Q3UTA8 Q3UTA8_MOUSE uc033ixi.1 uc033ixi.2 uc033ixi.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. nucleotide binding microtubule cytoskeleton organization molecular_function protein kinase activity protein serine/threonine kinase activity ATP binding cellular_component cytoplasm protein phosphorylation biological_process intracellular signal transduction tau-protein kinase activity uc033ixi.1 uc033ixi.2 uc033ixi.3 
ENSMUST00000191181.2 Gm29594 ENSMUST00000191181.2 Gm29594 (from geneSymbol) ENSMUST00000191181.1 uc289sdv.1 uc289sdv.2 uc289sdv.1 uc289sdv.2 
ENSMUST00000191185.7 Gm29386 ENSMUST00000191185.7 Gm29386 (from geneSymbol) ENSMUST00000191185.1 ENSMUST00000191185.2 ENSMUST00000191185.3 ENSMUST00000191185.4 ENSMUST00000191185.5 ENSMUST00000191185.6 uc292tbf.1 uc292tbf.2 uc292tbf.1 uc292tbf.2 
ENSMUST00000191190.2 Gm28173 ENSMUST00000191190.2 Gm28173 (from geneSymbol) ENSMUST00000191190.1 uc292sag.1 uc292sag.2 uc292sag.1 uc292sag.2 
ENSMUST00000191193.2 Gm28632 ENSMUST00000191193.2 Gm28632 (from geneSymbol) ENSMUST00000191193.1 uc292ugb.1 uc292ugb.2 uc292ugb.1 uc292ugb.2 
ENSMUST00000191194.7 Gm28764 ENSMUST00000191194.7 Gm28764 (from geneSymbol) ENSMUST00000191194.1 ENSMUST00000191194.2 ENSMUST00000191194.3 ENSMUST00000191194.4 ENSMUST00000191194.5 ENSMUST00000191194.6 uc292syd.1 uc292syd.2 uc292syd.1 uc292syd.2 
ENSMUST00000191203.7 Gm21698 ENSMUST00000191203.7 predicted gene, 21698 (from RefSeq NM_001378645.1) A0A087WQP8 A0A087WQP8_MOUSE ENSMUST00000191203.1 ENSMUST00000191203.2 ENSMUST00000191203.3 ENSMUST00000191203.4 ENSMUST00000191203.5 ENSMUST00000191203.6 Gm21698 NM_001378645 uc290tux.1 uc290tux.2 uc290tux.1 uc290tux.2 
ENSMUST00000191207.3 Gm19461 ENSMUST00000191207.3 predicted gene, 19461 (from RefSeq NR_037984.1) ENSMUST00000191207.1 ENSMUST00000191207.2 NR_037984 uc007cpw.1 uc007cpw.2 uc007cpw.3 uc007cpw.4 uc007cpw.5 uc007cpw.1 uc007cpw.2 uc007cpw.3 uc007cpw.4 uc007cpw.5 
ENSMUST00000191209.2 Gm29520 ENSMUST00000191209.2 Gm29520 (from geneSymbol) ENSMUST00000191209.1 uc287gjn.1 uc287gjn.2 uc287gjn.1 uc287gjn.2 
ENSMUST00000191217.2 Gm28194 ENSMUST00000191217.2 Gm28194 (from geneSymbol) ENSMUST00000191217.1 uc292tky.1 uc292tky.2 uc292tky.1 uc292tky.2 
ENSMUST00000191218.7 Fam181a ENSMUST00000191218.7 family with sequence similarity 181, member A, transcript variant 4 (from RefSeq NM_001413262.1) ENSMUST00000191218.1 ENSMUST00000191218.2 ENSMUST00000191218.3 ENSMUST00000191218.4 ENSMUST00000191218.5 ENSMUST00000191218.6 Fam181a J3QNB7 J3QNB7_MOUSE NM_001413262 uc033gfa.1 uc033gfa.2 uc033gfa.3 molecular_function cellular_component biological_process uc033gfa.1 uc033gfa.2 uc033gfa.3 
ENSMUST00000191222.2 2010106C02Rik ENSMUST00000191222.2 RIKEN cDNA 2010106C02 gene (from RefSeq NR_045435.1) ENSMUST00000191222.1 NR_045435 uc029tlc.1 uc029tlc.2 uc029tlc.3 uc029tlc.1 uc029tlc.2 uc029tlc.3 
ENSMUST00000191228.7 Pdc ENSMUST00000191228.7 phosducin, transcript variant 2 (from RefSeq NM_024458.2) ENSMUST00000191228.1 ENSMUST00000191228.2 ENSMUST00000191228.3 ENSMUST00000191228.4 ENSMUST00000191228.5 ENSMUST00000191228.6 NM_024458 PHOS_MOUSE Q9QW08 Rpr1 uc007cxw.1 uc007cxw.2 Inhibits the transcriptional activation activity of the cone- rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Interacts with CRX (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin. Cytoplasm, cytosol Nucleus Cell projection, cilium, photoreceptor outer segment Photoreceptor inner segment Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase. Belongs to the phosducin family. photoreceptor outer segment photoreceptor inner segment nucleus cytoplasm cytosol cilium visual perception cell projection response to stimulus uc007cxw.1 uc007cxw.2 
ENSMUST00000191233.4 Mindy4b-ps ENSMUST00000191233.4 Belongs to the MINDY deubiquitinase family. FAM188 subfamily. (from UniProt A0A1W2P7H6) A0A1W2P7H6 A0A1W2P7H6_MOUSE AK030561 ENSMUST00000191233.1 ENSMUST00000191233.2 ENSMUST00000191233.3 Mindy4b-ps uc290fly.1 uc290fly.2 Belongs to the MINDY deubiquitinase family. FAM188 subfamily. proteolysis cysteine-type carboxypeptidase activity protein K48-linked deubiquitination Lys48-specific deubiquitinase activity uc290fly.1 uc290fly.2 
ENSMUST00000191234.7 Nkain2 ENSMUST00000191234.7 Na+/K+ transporting ATPase interacting 2, transcript variant 1 (from RefSeq NM_001013411.2) A6MHP5 A6MHP6 A6MHP7 B2RUC0 ENSMUST00000191234.1 ENSMUST00000191234.2 ENSMUST00000191234.3 ENSMUST00000191234.4 ENSMUST00000191234.5 ENSMUST00000191234.6 NKAI2_MOUSE NM_001013411 Q4PNJ2 Q4PNJ3 Q5BLW8 Tcba1 uc007etw.1 uc007etw.2 uc007etw.3 uc007etw.4 Interacts with ATP1B1. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Transcript variant 1; IsoId=Q4PNJ2-1; Sequence=Displayed; Name=2; Synonyms=Transcript variant 3; IsoId=Q4PNJ2-2; Sequence=VSP_021903; Name=3; Synonyms=Transcript variant 2; IsoId=Q4PNJ2-3; Sequence=VSP_029299; Detected in the brain only and specifically in neurons; expressed in multiple regions such as cerebral cortex, thalamus, cerebellum, olfactory bulb and brainstem, but not in the hippocampus. Belongs to the NKAIN family. regulation of sodium ion transport plasma membrane membrane integral component of membrane uc007etw.1 uc007etw.2 uc007etw.3 uc007etw.4 
ENSMUST00000191240.3 Gm29264 ENSMUST00000191240.3 Gm29264 (from geneSymbol) AK155259 ENSMUST00000191240.1 ENSMUST00000191240.2 uc291bzl.1 uc291bzl.2 uc291bzl.3 uc291bzl.1 uc291bzl.2 uc291bzl.3 
ENSMUST00000191241.2 Gm29433 ENSMUST00000191241.2 Gm29433 (from geneSymbol) ENSMUST00000191241.1 uc292tfo.1 uc292tfo.2 uc292tfo.1 uc292tfo.2 
ENSMUST00000191251.7 Ica1l ENSMUST00000191251.7 islet cell autoantigen 1-like, transcript variant 4 (from RefSeq NM_001357296.2) Als2cr15 ENSMUST00000191251.1 ENSMUST00000191251.2 ENSMUST00000191251.3 ENSMUST00000191251.4 ENSMUST00000191251.5 ENSMUST00000191251.6 ICA1L_MOUSE NM_001357296 Q3TY65 Q6AXB8 Q6PD23 Q8C0R6 Q9D9S5 uc007bec.1 uc007bec.2 uc007bec.3 uc007bec.4 Sequence=BAB24634.1; Type=Erroneous initiation; Evidence=; acrosomal vesicle protein binding spermatid development protein domain specific binding uc007bec.1 uc007bec.2 uc007bec.3 uc007bec.4 
ENSMUST00000191253.7 Gm29398 ENSMUST00000191253.7 Gm29398 (from geneSymbol) AK042726 ENSMUST00000191253.1 ENSMUST00000191253.2 ENSMUST00000191253.3 ENSMUST00000191253.4 ENSMUST00000191253.5 ENSMUST00000191253.6 uc287mkm.1 uc287mkm.2 uc287mkm.1 uc287mkm.2 
ENSMUST00000191255.2 Scgb1b18 ENSMUST00000191255.2 Secreted (from UniProt A0A087WQJ0) A0A087WQJ0 A0A087WQJ0_MOUSE Abpa11_a18 ENSMUST00000191255.1 Scgb1b11 Scgb1b18 uc291oht.1 uc291oht.2 Secreted steroid binding extracellular region uc291oht.1 uc291oht.2 
ENSMUST00000191259.7 Gm28762 ENSMUST00000191259.7 Gm28762 (from geneSymbol) ENSMUST00000191259.1 ENSMUST00000191259.2 ENSMUST00000191259.3 ENSMUST00000191259.4 ENSMUST00000191259.5 ENSMUST00000191259.6 uc292syg.1 uc292syg.2 uc292syg.1 uc292syg.2 
ENSMUST00000191261.2 Gm28393 ENSMUST00000191261.2 Gm28393 (from geneSymbol) ENSMUST00000191261.1 uc292sca.1 uc292sca.2 uc292sca.1 uc292sca.2 
ENSMUST00000191268.7 Pik3r4 ENSMUST00000191268.7 phosphoinositide-3-kinase regulatory subunit 4 (from RefSeq NM_001081309.1) ENSMUST00000191268.1 ENSMUST00000191268.2 ENSMUST00000191268.3 ENSMUST00000191268.4 ENSMUST00000191268.5 ENSMUST00000191268.6 NM_001081309 PI3R4_MOUSE Q56A65 Q8C948 Q8C9D7 Q8VD65 Q9CVC5 Vps15 uc292klu.1 uc292klu.2 Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex the core of which is composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 associating with additional regulatory/auxilliary subunits to form alternative complex forms. Alternative complex forms containing a forth regulatory subunit in a mutually exclusive manner are PI3K complex I (PI3KC3-C1) containing ATG14, and PI3K complex II (PI3KC3-C2) containing UVRAG (PubMed:23332761). PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex. Both, PI3KC3-C1 and PI3KC3-C2, can associate with further regulatory subunits, such as RUBCN, SH3GLB1/Bif-1, AMBRA1 and NRBF2 (By similarity). PI3KC3-C1 probably associates with PIK3CB (PubMed:21059846). Interacts with RAB7A in the presence of PIK3C3/VPS34 (By similarity). Interacts with NRBF2 (By similarity). Interacts with ARMC3 (PubMed:34428398). Q8VD65; P23242: Gja1; NbExp=3; IntAct=EBI-6678184, EBI-298630; Late endosome Cytoplasmic vesicle, autophagosome Membrane ; Lipid-anchor Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes. Localizes also to discrete punctae along the ciliary axoneme (PubMed:24089209). Myristoylated. Probably autophosphorylated. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding endosome late endosome autophagosome axoneme protein phosphorylation protein targeting to vacuole microtubule cytoskeleton membrane macroautophagy kinase activity phosphorylation transferase activity pexophagy cytoplasmic vesicle regulation of cytokinesis receptor catabolic process phosphatidylinositol 3-kinase complex, class III, type I phosphatidylinositol 3-kinase complex, class III, type II phosphatidylinositol 3-kinase complex, class III cellular response to glucose starvation intracellular membrane-bounded organelle positive regulation of phosphatidylinositol 3-kinase activity late endosome to vacuole transport nucleus-vacuole junction uc292klu.1 uc292klu.2 
ENSMUST00000191270.2 Gm29217 ENSMUST00000191270.2 Gm29217 (from geneSymbol) ENSMUST00000191270.1 uc292uea.1 uc292uea.2 uc292uea.1 uc292uea.2 
ENSMUST00000191277.2 Gm28457 ENSMUST00000191277.2 Gm28457 (from geneSymbol) ENSMUST00000191277.1 uc292tiw.1 uc292tiw.2 uc292tiw.1 uc292tiw.2 
ENSMUST00000191298.2 Gm29438 ENSMUST00000191298.2 Gm29438 (from geneSymbol) AK081150 ENSMUST00000191298.1 uc291ftb.1 uc291ftb.2 uc291ftb.1 uc291ftb.2 
ENSMUST00000191305.7 Gm20843 ENSMUST00000191305.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WQA3) A0A087WQA3 A0A087WQA3_MOUSE ENSMUST00000191305.1 ENSMUST00000191305.2 ENSMUST00000191305.3 ENSMUST00000191305.4 ENSMUST00000191305.5 ENSMUST00000191305.6 FJ541091 Gm20843 Gm20888 Gm20937 Gm21209 Gm21518 uc292ukh.1 uc292ukh.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292ukh.1 uc292ukh.2 
ENSMUST00000191315.2 Gm28306 ENSMUST00000191315.2 Gm28306 (from geneSymbol) ENSMUST00000191315.1 uc287hdu.1 uc287hdu.2 uc287hdu.1 uc287hdu.2 
ENSMUST00000191321.2 Gm28183 ENSMUST00000191321.2 Gm28183 (from geneSymbol) ENSMUST00000191321.1 uc289zlf.1 uc289zlf.2 uc289zlf.1 uc289zlf.2 
ENSMUST00000191328.2 Gm29416 ENSMUST00000191328.2 Gm29416 (from geneSymbol) ENSMUST00000191328.1 uc292unp.1 uc292unp.2 uc292unp.1 uc292unp.2 
ENSMUST00000191344.2 Gm28133 ENSMUST00000191344.2 Gm28133 (from geneSymbol) ENSMUST00000191344.1 uc292ube.1 uc292ube.2 uc292ube.1 uc292ube.2 
ENSMUST00000191351.2 Gm29541 ENSMUST00000191351.2 Gm29541 (from geneSymbol) ENSMUST00000191351.1 uc288ftt.1 uc288ftt.2 uc288ftt.1 uc288ftt.2 
ENSMUST00000191354.2 Gm28549 ENSMUST00000191354.2 Gm28549 (from geneSymbol) ENSMUST00000191354.1 uc292tjo.1 uc292tjo.2 uc292tjo.1 uc292tjo.2 
ENSMUST00000191358.2 Gm20877 ENSMUST00000191358.2 Belongs to the SPIN/STSY family. (from UniProt J3QPZ4) ENSMUST00000191358.1 Gm20812 Gm20877 J3QPZ4 J3QPZ4_MOUSE uc057mcs.1 uc057mcs.2 uc057mcs.3 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc057mcs.1 uc057mcs.2 uc057mcs.3 
ENSMUST00000191359.3 2210022D18Rik ENSMUST00000191359.3 2210022D18Rik (from geneSymbol) AK008767 ENSMUST00000191359.1 ENSMUST00000191359.2 uc007qct.1 uc007qct.2 uc007qct.3 uc007qct.1 uc007qct.2 uc007qct.3 
ENSMUST00000191363.2 Gm28988 ENSMUST00000191363.2 Gm28988 (from geneSymbol) ENSMUST00000191363.1 uc288ptt.1 uc288ptt.2 uc288ptt.1 uc288ptt.2 
ENSMUST00000191372.2 Gm29250 ENSMUST00000191372.2 Gm29250 (from geneSymbol) ENSMUST00000191372.1 uc292tpv.1 uc292tpv.2 uc292tpv.1 uc292tpv.2 
ENSMUST00000191382.2 ENSMUSG00000121637 ENSMUST00000191382.2 ENSMUSG00000121637 (from geneSymbol) ENSMUST00000191382.1 uc292tws.1 uc292tws.2 uc292tws.1 uc292tws.2 
ENSMUST00000191389.7 Gm28332 ENSMUST00000191389.7 Gm28332 (from geneSymbol) ENSMUST00000191389.1 ENSMUST00000191389.2 ENSMUST00000191389.3 ENSMUST00000191389.4 ENSMUST00000191389.5 ENSMUST00000191389.6 uc292tck.1 uc292tck.2 uc292tck.1 uc292tck.2 
ENSMUST00000191393.2 BC001981 ENSMUST00000191393.2 BC001981 (from geneSymbol) ENSMUST00000191393.1 uc288pmp.1 uc288pmp.2 uc288pmp.1 uc288pmp.2 
ENSMUST00000191396.4 2010320M18Rik ENSMUST00000191396.4 RIKEN cDNA 2010320M18 gene (from RefSeq NR_029440.1) ENSMUST00000191396.1 ENSMUST00000191396.2 ENSMUST00000191396.3 NR_029440 uc009mbo.1 uc009mbo.2 uc009mbo.3 uc009mbo.4 uc009mbo.5 uc009mbo.6 uc009mbo.1 uc009mbo.2 uc009mbo.3 uc009mbo.4 uc009mbo.5 uc009mbo.6 
ENSMUST00000191406.2 Gm28461 ENSMUST00000191406.2 Gm28461 (from geneSymbol) ENSMUST00000191406.1 uc292tjd.1 uc292tjd.2 uc292tjd.1 uc292tjd.2 
ENSMUST00000191407.2 Ly6g6g ENSMUST00000191407.2 lymphocyte antigen 6 family member G6G, transcript variant 2 (from RefSeq NM_001384154.1) A0A087WRX0 A0A087WRX0_MOUSE D730001G18Rik ENSMUST00000191407.1 Ly6g6g NM_001384154 uc288yrg.1 uc288yrg.2 plasma membrane membrane acetylcholine receptor inhibitor activity negative regulation of receptor activity uc288yrg.1 uc288yrg.2 
ENSMUST00000191411.2 Gm28313 ENSMUST00000191411.2 Gm28313 (from geneSymbol) ENSMUST00000191411.1 uc292tnr.1 uc292tnr.2 uc292tnr.1 uc292tnr.2 
ENSMUST00000191419.2 ENSMUSG00000121334 ENSMUST00000191419.2 ENSMUSG00000121334 (from geneSymbol) ENSMUST00000191419.1 uc292ueg.1 uc292ueg.2 uc292ueg.1 uc292ueg.2 
ENSMUST00000191426.2 Smim41 ENSMUST00000191426.2 small integral membrane protein 41 (from RefSeq NM_001369218.1) 6030408B16Rik ENSMUST00000191426.1 NM_001369218 Q3UYR0 Q3UYR0_MOUSE Smim41 uc289bns.1 uc289bns.2 Membrane ; Single- pass membrane protein membrane integral component of membrane uc289bns.1 uc289bns.2 
ENSMUST00000191427.2 Gm29488 ENSMUST00000191427.2 Gm29488 (from geneSymbol) AK082049 ENSMUST00000191427.1 uc287lpc.1 uc287lpc.2 uc287lpc.1 uc287lpc.2 
ENSMUST00000191428.7 Fat1 ENSMUST00000191428.7 FAT atypical cadherin 1 (from RefSeq NM_001081286.3) ENSMUST00000191428.1 ENSMUST00000191428.2 ENSMUST00000191428.3 ENSMUST00000191428.4 ENSMUST00000191428.5 ENSMUST00000191428.6 F2Z4A3 F2Z4A3_MOUSE Fat1 NM_001081286 uc291zny.1 uc291zny.2 Lacks conserved residue(s) required for the propagation of feature annotation. epithelial cell morphogenesis calcium ion binding protein binding nucleus plasma membrane cell-cell junction actin filament organization cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules establishment or maintenance of cell polarity membrane integral component of membrane apical plasma membrane lamellipodium cell junction filopodium establishment or maintenance of epithelial cell apical/basal polarity perinuclear region of cytoplasm camera-type eye morphogenesis cell-cell adhesion uc291zny.1 uc291zny.2 
ENSMUST00000191441.2 1700019D03Rik ENSMUST00000191441.2 Binds to type I regulatory subunits of protein kinase A (PKA- RI) and may anchor/target them to the plasma membrane. (from UniProt Q9CPS8) AK010796 ENSMUST00000191441.1 Q9CPS8 SMAKA_MOUSE uc287ibv.1 uc287ibv.2 Binds to type I regulatory subunits of protein kinase A (PKA- RI) and may anchor/target them to the plasma membrane. Interacts with PKA type I regulatory subunits PRKAR1A and PRKAR1B. Also binds to type II regulatory subunits, but at a tenfold lower affinity (By similarity). Cell membrane Widely expressed, with very low levels in spleen and liver. May be palmitoylated at Cys-3. Belongs to the small membrane AKAP family. molecular_function plasma membrane biological_process membrane protein kinase A regulatory subunit binding uc287ibv.1 uc287ibv.2 
ENSMUST00000191443.7 Gm21865 ENSMUST00000191443.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRL2) A0A087WRL2 A0A087WRL2_MOUSE ENSMUST00000191443.1 ENSMUST00000191443.2 ENSMUST00000191443.3 ENSMUST00000191443.4 ENSMUST00000191443.5 ENSMUST00000191443.6 Gm21865 Gm30737 Gm35134 uc292tfm.1 uc292tfm.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292tfm.1 uc292tfm.2 
ENSMUST00000191452.4 9830004L10Rik ENSMUST00000191452.4 9830004L10Rik (from geneSymbol) AK009366 ENSMUST00000191452.1 ENSMUST00000191452.2 ENSMUST00000191452.3 uc287jqi.1 uc287jqi.2 uc287jqi.3 uc287jqi.4 uc287jqi.1 uc287jqi.2 uc287jqi.3 uc287jqi.4 
ENSMUST00000191453.2 Gm29430 ENSMUST00000191453.2 Gm29430 (from geneSymbol) ENSMUST00000191453.1 uc291emh.1 uc291emh.2 uc291emh.1 uc291emh.2 
ENSMUST00000191457.2 Gm29665 ENSMUST00000191457.2 Gm29665 (from geneSymbol) ENSMUST00000191457.1 uc287hya.1 uc287hya.2 uc287hya.1 uc287hya.2 
ENSMUST00000191478.2 Gm28137 ENSMUST00000191478.2 Gm28137 (from geneSymbol) ENSMUST00000191478.1 uc292ubf.1 uc292ubf.2 uc292ubf.1 uc292ubf.2 
ENSMUST00000191481.3 Gm28325 ENSMUST00000191481.3 Gm28325 (from geneSymbol) DQ874391 ENSMUST00000191481.1 ENSMUST00000191481.2 uc292tup.1 uc292tup.2 uc292tup.3 uc292tup.1 uc292tup.2 uc292tup.3 
ENSMUST00000191482.2 Gm28792 ENSMUST00000191482.2 Gm28792 (from geneSymbol) ENSMUST00000191482.1 uc287moy.1 uc287moy.2 uc287moy.1 uc287moy.2 
ENSMUST00000191490.2 Gm29612 ENSMUST00000191490.2 Gm29612 (from geneSymbol) ENSMUST00000191490.1 uc292txb.1 uc292txb.2 uc292txb.1 uc292txb.2 
ENSMUST00000191497.2 Usp27x ENSMUST00000191497.2 Deubiquitinase involved in innate antiviral immunity by mediating deubiquitination of CGAS and RIGI (PubMed:31534008). Negatively regulates RIGI by mediating 'Lys-63'-linked deubiquitination of RIGI, inhibiting type I interferon signaling (By similarity). Also regulates 'Lys-63'-linked ubiquitination level of MDA5/IFIH1 (By similarity). Acts as a positive regulator of the cGAS-STING pathway by catalyzing 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization (PubMed:31534008). Can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal (PubMed:27013495). By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity (PubMed:27013495). (from UniProt Q8CEG8) AK028249 B1ATV2 ENSMUST00000191497.1 Q8BSW2 Q8CEG8 Q9JIG5 UBP27_MOUSE Usp27 Usp27x uc292mwq.1 uc292mwq.2 Deubiquitinase involved in innate antiviral immunity by mediating deubiquitination of CGAS and RIGI (PubMed:31534008). Negatively regulates RIGI by mediating 'Lys-63'-linked deubiquitination of RIGI, inhibiting type I interferon signaling (By similarity). Also regulates 'Lys-63'-linked ubiquitination level of MDA5/IFIH1 (By similarity). Acts as a positive regulator of the cGAS-STING pathway by catalyzing 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization (PubMed:31534008). Can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal (PubMed:27013495). By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity (PubMed:27013495). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with phosphorylated BCL2L11 isoform BIMEL; this interaction leads to BCL2L11 deubiquitination and stabilization. Cytoplasm, cytosol Nucleus Belongs to the peptidase C19 family. Although strongly related to USP22, which deubiquitinates histones, lacks the N-terminal UBP-type zinc finger, suggesting it does not have the ability to deubiquitinate histones. Sequence=AAF66953.1; Type=Erroneous initiation; Evidence=; Sequence=BAC25840.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC25840.1; Type=Frameshift; Evidence=; Sequence=BAC26935.1; Type=Erroneous initiation; Evidence=; thiol-dependent ubiquitin-specific protease activity protein binding nucleus cytoplasm cytosol proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity positive regulation of apoptotic process protein stabilization Lys63-specific deubiquitinase activity protein K63-linked deubiquitination protein K48-linked deubiquitination Lys48-specific deubiquitinase activity uc292mwq.1 uc292mwq.2 
ENSMUST00000191501.2 Slc18a3 ENSMUST00000191501.2 solute carrier family 18 (vesicular monoamine), member 3 (from RefSeq NM_021712.3) ENSMUST00000191501.1 NM_021712 Q3TYJ1 Q3TYJ1_MOUSE Slc18a3 uc007szb.1 uc007szb.2 uc007szb.3 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein integral component of plasma membrane membrane integral component of membrane transmembrane transport uc007szb.1 uc007szb.2 uc007szb.3 
ENSMUST00000191515.8 Exoc1l ENSMUST00000191515.8 exocyst complex component 1 like (from RefSeq NR_033501.1) B9EK06 ENSMUST00000191515.1 ENSMUST00000191515.2 ENSMUST00000191515.3 ENSMUST00000191515.4 ENSMUST00000191515.5 ENSMUST00000191515.6 ENSMUST00000191515.7 EXC1L_MOUSE Exoc1l Gm7271 NR_033501 uc290wng.1 uc290wng.2 exocyst phosphatidylinositol-4,5-bisphosphate binding plasma membrane exocytosis Golgi to plasma membrane transport GTP-Rho binding exocyst localization uc290wng.1 uc290wng.2 
ENSMUST00000191517.2 Gm29626 ENSMUST00000191517.2 Gm29626 (from geneSymbol) ENSMUST00000191517.1 uc288rnh.1 uc288rnh.2 uc288rnh.1 uc288rnh.2 
ENSMUST00000191518.2 Gm28872 ENSMUST00000191518.2 Gm28872 (from geneSymbol) ENSMUST00000191518.1 uc290qkd.1 uc290qkd.2 uc290qkd.1 uc290qkd.2 
ENSMUST00000191519.2 Gm28639 ENSMUST00000191519.2 Gm28639 (from geneSymbol) ENSMUST00000191519.1 uc289wbn.1 uc289wbn.2 uc289wbn.1 uc289wbn.2 
ENSMUST00000191526.2 Gm29560 ENSMUST00000191526.2 Gm29560 (from geneSymbol) ENSMUST00000191526.1 uc290ijc.1 uc290ijc.2 uc290ijc.1 uc290ijc.2 
ENSMUST00000191530.2 Gm29522 ENSMUST00000191530.2 Gm29522 (from geneSymbol) ENSMUST00000191530.1 uc292sfk.1 uc292sfk.2 uc292sfk.1 uc292sfk.2 
ENSMUST00000191531.2 Gm28902 ENSMUST00000191531.2 Gm28902 (from geneSymbol) ENSMUST00000191531.1 uc287jkm.1 uc287jkm.2 uc287jkm.1 uc287jkm.2 
ENSMUST00000191542.7 Gm28425 ENSMUST00000191542.7 Gm28425 (from geneSymbol) ENSMUST00000191542.1 ENSMUST00000191542.2 ENSMUST00000191542.3 ENSMUST00000191542.4 ENSMUST00000191542.5 ENSMUST00000191542.6 uc292tgy.1 uc292tgy.2 uc292tgy.1 uc292tgy.2 
ENSMUST00000191551.7 Gm28245 ENSMUST00000191551.7 Gm28245 (from geneSymbol) ENSMUST00000191551.1 ENSMUST00000191551.2 ENSMUST00000191551.3 ENSMUST00000191551.4 ENSMUST00000191551.5 ENSMUST00000191551.6 uc292ssr.1 uc292ssr.2 uc292ssr.1 uc292ssr.2 
ENSMUST00000191553.7 Gm21258 ENSMUST00000191553.7 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WQC7) A0A087WQC7 A0A087WQC7_MOUSE BC100464 ENSMUST00000191553.1 ENSMUST00000191553.2 ENSMUST00000191553.3 ENSMUST00000191553.4 ENSMUST00000191553.5 ENSMUST00000191553.6 Gm20736 Gm21258 uc292tpc.1 uc292tpc.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292tpc.1 uc292tpc.2 
ENSMUST00000191561.2 Gm28691 ENSMUST00000191561.2 Gm28691 (from geneSymbol) ENSMUST00000191561.1 uc292tvy.1 uc292tvy.2 uc292tvy.1 uc292tvy.2 
ENSMUST00000191563.2 9430060I03Rik ENSMUST00000191563.2 RIKEN cDNA 9430060I03 gene (from RefSeq NR_015525.1) ENSMUST00000191563.1 NR_015525 uc011wpn.1 uc011wpn.2 uc011wpn.3 uc011wpn.1 uc011wpn.2 uc011wpn.3 
ENSMUST00000191564.2 Gm29042 ENSMUST00000191564.2 Gm29042 (from geneSymbol) ENSMUST00000191564.1 uc292thp.1 uc292thp.2 uc292thp.1 uc292thp.2 
ENSMUST00000191565.7 Flacc1 ENSMUST00000191565.7 flagellum associated containing coiled-coil domains 1, transcript variant 4 (from RefSeq NM_001347056.1) A0A087WNN1 A0A087WNN1_MOUSE Als2cr12 ENSMUST00000191565.1 ENSMUST00000191565.2 ENSMUST00000191565.3 ENSMUST00000191565.4 ENSMUST00000191565.5 ENSMUST00000191565.6 Flacc1 NM_001347056 uc011wlm.1 uc011wlm.2 uc011wlm.3 uc011wlm.4 uc011wlm.5 uc011wlm.1 uc011wlm.2 uc011wlm.3 uc011wlm.4 uc011wlm.5 
ENSMUST00000191576.2 Gm28499 ENSMUST00000191576.2 Gm28499 (from geneSymbol) ENSMUST00000191576.1 uc287kgy.1 uc287kgy.2 uc287kgy.1 uc287kgy.2 
ENSMUST00000191581.3 Gm28588 ENSMUST00000191581.3 Gm28588 (from geneSymbol) AK007945 ENSMUST00000191581.1 ENSMUST00000191581.2 uc292rvj.1 uc292rvj.2 uc292rvj.3 uc292rvj.1 uc292rvj.2 uc292rvj.3 
ENSMUST00000191586.3 Gm28086 ENSMUST00000191586.3 Gm28086 (from geneSymbol) ENSMUST00000191586.1 ENSMUST00000191586.2 uc287koc.1 uc287koc.2 uc287koc.3 uc287koc.1 uc287koc.2 uc287koc.3 
ENSMUST00000191588.7 Gm29132 ENSMUST00000191588.7 Gm29132 (from geneSymbol) DQ874391 ENSMUST00000191588.1 ENSMUST00000191588.2 ENSMUST00000191588.3 ENSMUST00000191588.4 ENSMUST00000191588.5 ENSMUST00000191588.6 uc292tvq.1 uc292tvq.2 uc292tvq.1 uc292tvq.2 
ENSMUST00000191602.2 Ajm1 ENSMUST00000191602.2 apical junction component 1, transcript variant 2 (from RefSeq NM_001399245.1) A2AJA9 AJM1_MOUSE ENSMUST00000191602.1 Gm996 NM_001399245 Q6P0A3 uc289tzo.1 uc289tzo.2 May be involved in the control of adherens junction integrity. Apical cell membrane Cell projection, cilium Cell junction, adherens junction Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A2AJA9-1; Sequence=Displayed; Name=2; IsoId=A2AJA9-2; Sequence=VSP_038820; molecular_function cellular_component plasma membrane adherens junction cilium biological_process membrane apical plasma membrane cell junction cell projection cell-cell junction organization uc289tzo.1 uc289tzo.2 
ENSMUST00000191603.7 2900052N01Rik ENSMUST00000191603.7 2900052N01Rik (from geneSymbol) AK049847 ENSMUST00000191603.1 ENSMUST00000191603.2 ENSMUST00000191603.3 ENSMUST00000191603.4 ENSMUST00000191603.5 ENSMUST00000191603.6 uc009phl.1 uc009phl.2 uc009phl.3 uc009phl.1 uc009phl.2 uc009phl.3 
ENSMUST00000191612.2 Gm36938 ENSMUST00000191612.2 Gm36938 (from geneSymbol) AK137646 ENSMUST00000191612.1 uc287mbh.1 uc287mbh.2 uc287mbh.1 uc287mbh.2 
ENSMUST00000191614.2 Gm38042 ENSMUST00000191614.2 Gm38042 (from geneSymbol) AK142804 ENSMUST00000191614.1 uc292dce.1 uc292dce.2 uc292dce.1 uc292dce.2 
ENSMUST00000191616.3 Gm37950 ENSMUST00000191616.3 Gm37950 (from geneSymbol) ENSMUST00000191616.1 ENSMUST00000191616.2 uc287nxs.1 uc287nxs.2 uc287nxs.3 uc287nxs.1 uc287nxs.2 uc287nxs.3 
ENSMUST00000191619.2 Gm37278 ENSMUST00000191619.2 Gm37278 (from geneSymbol) AK051567 ENSMUST00000191619.1 uc287lmh.1 uc287lmh.2 uc287lmh.1 uc287lmh.2 
ENSMUST00000191620.2 Gm37803 ENSMUST00000191620.2 Gm37803 (from geneSymbol) ENSMUST00000191620.1 uc290klo.1 uc290klo.2 uc290klo.1 uc290klo.2 
ENSMUST00000191623.2 Gm37639 ENSMUST00000191623.2 Gm37639 (from geneSymbol) ENSMUST00000191623.1 uc289mqo.1 uc289mqo.2 uc289mqo.1 uc289mqo.2 
ENSMUST00000191624.2 Gm37923 ENSMUST00000191624.2 Gm37923 (from geneSymbol) ENSMUST00000191624.1 uc287nmk.1 uc287nmk.2 uc287nmk.1 uc287nmk.2 
ENSMUST00000191628.2 Gm37531 ENSMUST00000191628.2 Gm37531 (from geneSymbol) ENSMUST00000191628.1 LF192674 uc287ine.1 uc287ine.2 uc287ine.1 uc287ine.2 
ENSMUST00000191630.2 Gm37877 ENSMUST00000191630.2 Gm37877 (from geneSymbol) ENSMUST00000191630.1 uc287kuc.1 uc287kuc.2 uc287kuc.1 uc287kuc.2 
ENSMUST00000191632.2 D330025C20Rik ENSMUST00000191632.2 RIKEN cDNA D330025C20 gene (from RefSeq NR_168057.1) ENSMUST00000191632.1 NR_168057 uc289pto.1 uc289pto.2 uc289pto.1 uc289pto.2 
ENSMUST00000191634.2 Gm37856 ENSMUST00000191634.2 Gm37856 (from geneSymbol) BC027659 ENSMUST00000191634.1 uc287nls.1 uc287nls.2 uc287nls.1 uc287nls.2 
ENSMUST00000191635.2 Gm37772 ENSMUST00000191635.2 Gm37772 (from geneSymbol) AK089413 ENSMUST00000191635.1 uc287ljg.1 uc287ljg.2 uc287ljg.1 uc287ljg.2 
ENSMUST00000191637.2 Gm37727 ENSMUST00000191637.2 Gm37727 (from geneSymbol) ENSMUST00000191637.1 uc288pas.1 uc288pas.2 uc288pas.1 uc288pas.2 
ENSMUST00000191641.2 Gm37984 ENSMUST00000191641.2 Gm37984 (from geneSymbol) ENSMUST00000191641.1 uc287oks.1 uc287oks.2 uc287oks.1 uc287oks.2 
ENSMUST00000191643.2 Gm37229 ENSMUST00000191643.2 Gm37229 (from geneSymbol) ENSMUST00000191643.1 uc290fdw.1 uc290fdw.2 uc290fdw.1 uc290fdw.2 
ENSMUST00000191644.2 Gm37226 ENSMUST00000191644.2 Gm37226 (from geneSymbol) ENSMUST00000191644.1 LF197728 uc292jlx.1 uc292jlx.2 uc292jlx.1 uc292jlx.2 
ENSMUST00000191646.6 Trbv30 ENSMUST00000191646.6 Trbv30 (from geneSymbol) A0A0B4J1P1 A0A0B4J1P1_MOUSE ENSMUST00000191646.1 ENSMUST00000191646.2 ENSMUST00000191646.3 ENSMUST00000191646.4 ENSMUST00000191646.5 M14294 Trbv30 uc291duz.1 uc291duz.2 uc291duz.1 uc291duz.2 
ENSMUST00000191648.2 Gm38224 ENSMUST00000191648.2 Gm38224 (from geneSymbol) ENSMUST00000191648.1 uc287guf.1 uc287guf.2 uc287guf.1 uc287guf.2 
ENSMUST00000191652.2 Gm37158 ENSMUST00000191652.2 Gm37158 (from geneSymbol) AB352940 ENSMUST00000191652.1 uc292sjs.1 uc292sjs.2 uc292sjs.1 uc292sjs.2 
ENSMUST00000191654.3 Gm38165 ENSMUST00000191654.3 Gm38165 (from geneSymbol) AK005683 ENSMUST00000191654.1 ENSMUST00000191654.2 uc289phj.1 uc289phj.2 uc289phj.3 uc289phj.1 uc289phj.2 uc289phj.3 
ENSMUST00000191655.2 Gm37718 ENSMUST00000191655.2 Gm37718 (from geneSymbol) ENSMUST00000191655.1 LF192901 uc287mfz.1 uc287mfz.2 uc287mfz.1 uc287mfz.2 
ENSMUST00000191656.2 Gm37101 ENSMUST00000191656.2 Gm37101 (from geneSymbol) AK030102 ENSMUST00000191656.1 uc287mfb.1 uc287mfb.2 uc287mfb.1 uc287mfb.2 
ENSMUST00000191658.2 Gm37293 ENSMUST00000191658.2 Gm37293 (from geneSymbol) BC116196 ENSMUST00000191658.1 uc287mds.1 uc287mds.2 uc287mds.1 uc287mds.2 
ENSMUST00000191660.2 Gm38166 ENSMUST00000191660.2 Gm38166 (from geneSymbol) ENSMUST00000191660.1 uc290ezs.1 uc290ezs.2 uc290ezs.1 uc290ezs.2 
ENSMUST00000191663.2 Gm55759 ENSMUST00000191663.2 Gm55759 (from geneSymbol) AK046063 ENSMUST00000191663.1 uc287ovk.1 uc287ovk.2 uc287ovk.1 uc287ovk.2 
ENSMUST00000191665.6 Gm37346 ENSMUST00000191665.6 Gm37346 (from geneSymbol) ENSMUST00000191665.1 ENSMUST00000191665.2 ENSMUST00000191665.3 ENSMUST00000191665.4 ENSMUST00000191665.5 uc292srv.1 uc292srv.2 uc292srv.1 uc292srv.2 
ENSMUST00000191669.2 Gm37593 ENSMUST00000191669.2 Gm37593 (from geneSymbol) AK158910 ENSMUST00000191669.1 uc289lwg.1 uc289lwg.2 uc289lwg.1 uc289lwg.2 
ENSMUST00000191675.2 Gm29866 ENSMUST00000191675.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A0A6YX04) A0A0A6YX04 A0A0A6YX04_MOUSE BC100464 ENSMUST00000191675.1 Gm29866 uc292smo.1 uc292smo.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292smo.1 uc292smo.2 
ENSMUST00000191676.2 Gm38302 ENSMUST00000191676.2 Gm38302 (from geneSymbol) ENSMUST00000191676.1 uc057avr.1 uc057avr.2 uc057avr.1 uc057avr.2 
ENSMUST00000191677.6 Sema4c ENSMUST00000191677.6 Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. (from UniProt Q64151) ENSMUST00000191677.1 ENSMUST00000191677.2 ENSMUST00000191677.3 ENSMUST00000191677.4 ENSMUST00000191677.5 Q64151 S4c S79463 SEM4C_MOUSE Semacl1 Semai uc287hhx.1 uc287hhx.2 Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain). Interacts with NCDN. Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2. Q64151; Q9Z0G0: Gipc1; NbExp=8; IntAct=EBI-987075, EBI-300855; Q64151; Q9Z2H7: Gipc2; NbExp=3; IntAct=EBI-987075, EBI-987119; Postsynaptic density membrane ; Single-pass type I membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein Predominantly expressed in brain (at protein level). First detected at 14 dpc, levels increase by birth and remain strong in the adult brain (at protein level). Expressed widely in the nervous tissues during development. Up-regulated in differentiating myoblasts and upon muscle regeneration (at protein level). Partial neonate lethality, due to defects in brain and neural tube development. In about one third of the embryos cranial neural folds fail to converge, leading to an open neural tube and exencephaly. Mice without exencephaly are viable and fertile. Belongs to the semaphorin family. neural crest cell migration neural tube closure protein binding extracellular space plasma membrane integral component of plasma membrane multicellular organism development nervous system development postsynaptic density membrane integral component of membrane cell migration in hindbrain cerebellum development cell junction cell differentiation semaphorin receptor binding positive regulation of cell migration synaptic vesicle membrane cytoplasmic vesicle positive regulation of stress-activated MAPK cascade muscle cell differentiation synapse postsynaptic membrane chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway uc287hhx.1 uc287hhx.2 
ENSMUST00000191682.6 Gm30174 ENSMUST00000191682.6 Gm30174 (from geneSymbol) ENSMUST00000191682.1 ENSMUST00000191682.2 ENSMUST00000191682.3 ENSMUST00000191682.4 ENSMUST00000191682.5 uc292sig.1 uc292sig.2 uc292sig.1 uc292sig.2 
ENSMUST00000191685.2 Gm37831 ENSMUST00000191685.2 Gm37831 (from geneSymbol) ENSMUST00000191685.1 uc290dwa.1 uc290dwa.2 uc290dwa.1 uc290dwa.2 
ENSMUST00000191687.2 Gm37519 ENSMUST00000191687.2 Gm37519 (from geneSymbol) ENSMUST00000191687.1 uc287ofn.1 uc287ofn.2 uc287ofn.1 uc287ofn.2 
ENSMUST00000191688.2 Gm37084 ENSMUST00000191688.2 Gm37084 (from geneSymbol) ENSMUST00000191688.1 uc287lod.1 uc287lod.2 uc287lod.1 uc287lod.2 
ENSMUST00000191693.2 Ighv3-3 ENSMUST00000191693.2 Ighv3-3 (from geneSymbol) A0A0A6YWL2 A0A0A6YWL2_MOUSE ENSMUST00000191693.1 Ighv3-3 uc288jvz.1 uc288jvz.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jvz.1 uc288jvz.2 
ENSMUST00000191694.2 1700008A23Rik ENSMUST00000191694.2 1700008A23Rik (from geneSymbol) AK005751 ENSMUST00000191694.1 uc292jyj.1 uc292jyj.2 uc292jyj.1 uc292jyj.2 
ENSMUST00000191698.2 Gm37265 ENSMUST00000191698.2 Gm37265 (from geneSymbol) ENSMUST00000191698.1 uc287hog.1 uc287hog.2 uc287hog.1 uc287hog.2 
ENSMUST00000191700.2 Gm37959 ENSMUST00000191700.2 Gm37959 (from geneSymbol) AK139080 ENSMUST00000191700.1 uc287jun.1 uc287jun.2 uc287jun.1 uc287jun.2 
ENSMUST00000191701.2 F830212C03Rik ENSMUST00000191701.2 F830212C03Rik (from geneSymbol) ENSMUST00000191701.1 uc288xbl.1 uc288xbl.2 uc288xbl.1 uc288xbl.2 
ENSMUST00000191702.2 Gm38245 ENSMUST00000191702.2 Gm38245 (from geneSymbol) ENSMUST00000191702.1 uc287oxf.1 uc287oxf.2 uc287oxf.1 uc287oxf.2 
ENSMUST00000191704.2 4833421G17Rik ENSMUST00000191704.2 4833421G17Rik (from geneSymbol) AK014745 ENSMUST00000191704.1 uc287kei.1 uc287kei.2 uc287kei.1 uc287kei.2 
ENSMUST00000191707.2 Gm38103 ENSMUST00000191707.2 Gm38103 (from geneSymbol) AK050890 ENSMUST00000191707.1 uc288gmt.1 uc288gmt.2 uc288gmt.1 uc288gmt.2 
ENSMUST00000191708.2 Gm37162 ENSMUST00000191708.2 Gm37162 (from geneSymbol) ENSMUST00000191708.1 uc287gnw.1 uc287gnw.2 uc287gnw.1 uc287gnw.2 
ENSMUST00000191710.2 Gm38124 ENSMUST00000191710.2 Gm38124 (from geneSymbol) ENSMUST00000191710.1 uc290ezj.1 uc290ezj.2 uc290ezj.1 uc290ezj.2 
ENSMUST00000191712.2 Gm37183 ENSMUST00000191712.2 Gm37183 (from geneSymbol) ENSMUST00000191712.1 uc288vet.1 uc288vet.2 uc288vet.1 uc288vet.2 
ENSMUST00000191714.2 Gm37786 ENSMUST00000191714.2 Gm37786 (from geneSymbol) ENSMUST00000191714.1 uc287qqn.1 uc287qqn.2 uc287qqn.1 uc287qqn.2 
ENSMUST00000191716.6 Gm37231 ENSMUST00000191716.6 Gm37231 (from geneSymbol) ENSMUST00000191716.1 ENSMUST00000191716.2 ENSMUST00000191716.3 ENSMUST00000191716.4 ENSMUST00000191716.5 uc292sgv.1 uc292sgv.2 uc292sgv.1 uc292sgv.2 
ENSMUST00000191717.6 Gm38168 ENSMUST00000191717.6 Gm38168 (from geneSymbol) ENSMUST00000191717.1 ENSMUST00000191717.2 ENSMUST00000191717.3 ENSMUST00000191717.4 ENSMUST00000191717.5 uc292slw.1 uc292slw.2 uc292slw.1 uc292slw.2 
ENSMUST00000191718.2 Gm38348 ENSMUST00000191718.2 Gm38348 (from geneSymbol) ENSMUST00000191718.1 uc289sro.1 uc289sro.2 uc289sro.1 uc289sro.2 
ENSMUST00000191720.2 B430319G15Rik ENSMUST00000191720.2 RIKEN cDNA B430319G15 gene (from RefSeq NR_029474.1) ENSMUST00000191720.1 NR_029474 uc009rat.1 uc009rat.2 uc009rat.3 uc009rat.1 uc009rat.2 uc009rat.3 
ENSMUST00000191723.2 Gm37059 ENSMUST00000191723.2 Gm37059 (from geneSymbol) ENSMUST00000191723.1 uc292sja.1 uc292sja.2 uc292sja.1 uc292sja.2 
ENSMUST00000191734.2 Gm37258 ENSMUST00000191734.2 Gm37258 (from geneSymbol) ENSMUST00000191734.1 uc287oot.1 uc287oot.2 uc287oot.1 uc287oot.2 
ENSMUST00000191736.2 Gm37241 ENSMUST00000191736.2 Gm37241 (from geneSymbol) AK087619 ENSMUST00000191736.1 uc289foz.1 uc289foz.2 uc289foz.1 uc289foz.2 
ENSMUST00000191737.2 Gm38244 ENSMUST00000191737.2 Gm38244 (from geneSymbol) ENSMUST00000191737.1 uc290imp.1 uc290imp.2 uc290imp.1 uc290imp.2 
ENSMUST00000191738.6 Gm36950 ENSMUST00000191738.6 Gm36950 (from geneSymbol) ENSMUST00000191738.1 ENSMUST00000191738.2 ENSMUST00000191738.3 ENSMUST00000191738.4 ENSMUST00000191738.5 uc292smp.1 uc292smp.2 uc292smp.1 uc292smp.2 
ENSMUST00000191740.2 Gm37040 ENSMUST00000191740.2 Gm37040 (from geneSymbol) ENSMUST00000191740.1 uc292jpq.1 uc292jpq.2 uc292jpq.1 uc292jpq.2 
ENSMUST00000191742.6 Gm37739 ENSMUST00000191742.6 Gm37739 (from geneSymbol) ENSMUST00000191742.1 ENSMUST00000191742.2 ENSMUST00000191742.3 ENSMUST00000191742.4 ENSMUST00000191742.5 uc292sgn.1 uc292sgn.2 uc292sgn.1 uc292sgn.2 
ENSMUST00000191743.2 Gm37837 ENSMUST00000191743.2 Gm37837 (from geneSymbol) AK144738 ENSMUST00000191743.1 uc292jec.1 uc292jec.2 uc292jec.1 uc292jec.2 
ENSMUST00000191748.2 Gm37244 ENSMUST00000191748.2 Gm37244 (from geneSymbol) AK156221 ENSMUST00000191748.1 uc290dwc.1 uc290dwc.2 uc290dwc.1 uc290dwc.2 
ENSMUST00000191749.2 Gm37604 ENSMUST00000191749.2 Gm37604 (from geneSymbol) AB351413 ENSMUST00000191749.1 uc287mhm.1 uc287mhm.2 uc287mhm.1 uc287mhm.2 
ENSMUST00000191750.2 Gm37383 ENSMUST00000191750.2 Gm37383 (from geneSymbol) ENSMUST00000191750.1 uc287mtx.1 uc287mtx.2 uc287mtx.1 uc287mtx.2 
ENSMUST00000191751.2 Gm38143 ENSMUST00000191751.2 Gm38143 (from geneSymbol) ENSMUST00000191751.1 uc291rlp.1 uc291rlp.2 uc291rlp.1 uc291rlp.2 
ENSMUST00000191753.3 Gm44573 ENSMUST00000191753.3 Gm44573 (from geneSymbol) ENSMUST00000191753.1 ENSMUST00000191753.2 LF196232 uc291osn.1 uc291osn.2 uc291osn.1 uc291osn.2 
ENSMUST00000191756.2 Gm37646 ENSMUST00000191756.2 Gm37646 (from geneSymbol) ENSMUST00000191756.1 uc290fcr.1 uc290fcr.2 uc290fcr.1 uc290fcr.2 
ENSMUST00000191758.6 Tmem131l ENSMUST00000191758.6 transmembrane 131 like, transcript variant 1 (from RefSeq NM_172681.5) ENSMUST00000191758.1 ENSMUST00000191758.2 ENSMUST00000191758.3 ENSMUST00000191758.4 ENSMUST00000191758.5 Kiaa0922 NM_172681 Q3U3D7 Q6P5E2 Q6PHM5 Q6ZQ24 Q8C2B9 Q8K2U7 Q8R3Y2 Q8R580 T131L_MOUSE Tmem131l uc008ppp.1 uc008ppp.2 uc008ppp.3 In its membrane-associated form, antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. Cell membrane ; Single-pass type I membrane protein Endoplasmic reticulum Cytoplasm Note=During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U3D7-1; Sequence=Displayed; Name=2; IsoId=Q3U3D7-2; Sequence=VSP_032833; Name=3; IsoId=Q3U3D7-3; Sequence=VSP_032832, VSP_032833, VSP_032834; Belongs to the TMEM131 family. Sequence=AAH29771.1; Type=Miscellaneous discrepancy; Evidence=; Sequence=AAH62940.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC40642.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cytoplasm endoplasmic reticulum plasma membrane membrane integral component of membrane Wnt signaling pathway negative regulation of immature T cell proliferation in thymus negative regulation of canonical Wnt signaling pathway uc008ppp.1 uc008ppp.2 uc008ppp.3 
ENSMUST00000191759.2 Gm37530 ENSMUST00000191759.2 Gm37530 (from geneSymbol) ENSMUST00000191759.1 LF229676 uc290maa.1 uc290maa.2 uc290maa.1 uc290maa.2 
ENSMUST00000191764.2 6030460B20Rik ENSMUST00000191764.2 6030460B20Rik (from geneSymbol) ENSMUST00000191764.1 uc287ioj.1 uc287ioj.2 uc287ioj.1 uc287ioj.2 
ENSMUST00000191765.2 Gm37695 ENSMUST00000191765.2 Gm37695 (from geneSymbol) ENSMUST00000191765.1 uc287xon.1 uc287xon.2 uc287xon.1 uc287xon.2 
ENSMUST00000191767.3 Gm35584 ENSMUST00000191767.3 Gm35584 (from geneSymbol) ENSMUST00000191767.1 ENSMUST00000191767.2 uc290fvh.1 uc290fvh.2 uc290fvh.3 uc290fvh.1 uc290fvh.2 uc290fvh.3 
ENSMUST00000191768.2 Gm37741 ENSMUST00000191768.2 Gm37741 (from geneSymbol) ENSMUST00000191768.1 uc292orb.1 uc292orb.2 uc292orb.1 uc292orb.2 
ENSMUST00000191770.2 2900092O11Rik ENSMUST00000191770.2 2900092O11Rik (from geneSymbol) AK013844 ENSMUST00000191770.1 uc287osb.1 uc287osb.2 uc287osb.1 uc287osb.2 
ENSMUST00000191771.2 Gm37367 ENSMUST00000191771.2 Gm37367 (from geneSymbol) ENSMUST00000191771.1 uc287mxt.1 uc287mxt.2 uc287mxt.1 uc287mxt.2 
ENSMUST00000191772.2 Gm38198 ENSMUST00000191772.2 Gm38198 (from geneSymbol) DQ541161 ENSMUST00000191772.1 uc287gyh.1 uc287gyh.2 uc287gyh.1 uc287gyh.2 
ENSMUST00000191778.2 Gm37609 ENSMUST00000191778.2 Gm37609 (from geneSymbol) ENSMUST00000191778.1 uc292dpn.1 uc292dpn.2 uc292dpn.1 uc292dpn.2 
ENSMUST00000191779.3 1700001G17Rik ENSMUST00000191779.3 1700001G17Rik (from geneSymbol) AK005592 ENSMUST00000191779.1 ENSMUST00000191779.2 uc007ant.1 uc007ant.2 uc007ant.3 uc007ant.4 uc007ant.5 uc007ant.6 uc007ant.7 uc007ant.1 uc007ant.2 uc007ant.3 uc007ant.4 uc007ant.5 uc007ant.6 uc007ant.7 
ENSMUST00000191784.2 Gm37857 ENSMUST00000191784.2 Gm37857 (from geneSymbol) AK009453 ENSMUST00000191784.1 uc290hgb.1 uc290hgb.2 uc290hgb.1 uc290hgb.2 
ENSMUST00000191787.6 Gm38174 ENSMUST00000191787.6 Gm38174 (from geneSymbol) ENSMUST00000191787.1 ENSMUST00000191787.2 ENSMUST00000191787.3 ENSMUST00000191787.4 ENSMUST00000191787.5 uc292sml.1 uc292sml.2 uc292sml.1 uc292sml.2 
ENSMUST00000191792.2 Gm38258 ENSMUST00000191792.2 Gm38258 (from geneSymbol) ENSMUST00000191792.1 uc290ehg.1 uc290ehg.2 uc290ehg.1 uc290ehg.2 
ENSMUST00000191796.2 Gm37460 ENSMUST00000191796.2 Gm37460 (from geneSymbol) AK082393 ENSMUST00000191796.1 uc292kbz.1 uc292kbz.2 uc292kbz.1 uc292kbz.2 
ENSMUST00000191800.2 Gm36991 ENSMUST00000191800.2 Gm36991 (from geneSymbol) ENSMUST00000191800.1 uc288pfh.1 uc288pfh.2 uc288pfh.1 uc288pfh.2 
ENSMUST00000191801.2 Ighv1-11 ENSMUST00000191801.2 Ighv1-11 (from geneSymbol) A0A0A6YWI9 A0A0A6YWI9_MOUSE ENSMUST00000191801.1 Ighv1-11 uc288jxs.1 uc288jxs.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jxs.1 uc288jxs.2 
ENSMUST00000191803.2 Ighv1-5 ENSMUST00000191803.2 Ighv1-5 (from geneSymbol) A0A0A6YWG2 A0A0A6YWG2_MOUSE ENSMUST00000191803.1 Ighv1-5 JF412709 uc288jxh.1 uc288jxh.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jxh.1 uc288jxh.2 
ENSMUST00000191805.7 Larp1b ENSMUST00000191805.7 La ribonucleoprotein 1B, transcript variant 4 (from RefSeq NM_001394999.1) A0A0A6YWC2 A0A0A6YWC2_MOUSE ENSMUST00000191805.1 ENSMUST00000191805.2 ENSMUST00000191805.3 ENSMUST00000191805.4 ENSMUST00000191805.5 ENSMUST00000191805.6 Larp1b NM_001394999 uc008pca.1 uc008pca.2 molecular_function RNA binding cellular_component biological_process uc008pca.1 uc008pca.2 
ENSMUST00000191807.6 Gm36261 ENSMUST00000191807.6 Gm36261 (from geneSymbol) ENSMUST00000191807.1 ENSMUST00000191807.2 ENSMUST00000191807.3 ENSMUST00000191807.4 ENSMUST00000191807.5 uc292smd.1 uc292smd.2 uc292smd.1 uc292smd.2 
ENSMUST00000191810.2 1700006P03Rik ENSMUST00000191810.2 1700006P03Rik (from geneSymbol) AK005685 ENSMUST00000191810.1 uc287mdn.1 uc287mdn.2 uc287mdn.1 uc287mdn.2 
ENSMUST00000191811.2 Gm37632 ENSMUST00000191811.2 Gm37632 (from geneSymbol) ENSMUST00000191811.1 uc287meg.1 uc287meg.2 uc287meg.1 uc287meg.2 
ENSMUST00000191816.2 Gm37606 ENSMUST00000191816.2 Gm37606 (from geneSymbol) ENSMUST00000191816.1 uc289fpc.1 uc289fpc.2 uc289fpc.1 uc289fpc.2 
ENSMUST00000191817.2 1700113B19Rik ENSMUST00000191817.2 1700113B19Rik (from geneSymbol) AK007192 ENSMUST00000191817.1 uc287mev.1 uc287mev.2 uc287mev.1 uc287mev.2 
ENSMUST00000191819.2 Gm38031 ENSMUST00000191819.2 Gm38031 (from geneSymbol) AK038770 ENSMUST00000191819.1 uc287kvh.1 uc287kvh.2 uc287kvh.1 uc287kvh.2 
ENSMUST00000191820.3 Tlr5 ENSMUST00000191820.3 toll-like receptor 5 (from RefSeq NM_016928.4) ENSMUST00000191820.1 ENSMUST00000191820.2 NM_016928 Q05AH3 Q05AH3_MOUSE Tlr5 uc287oqe.1 uc287oqe.2 Membrane ; Single- pass type I membrane protein Belongs to the Toll-like receptor family. positive regulation of cytokine production immune system process MyD88-dependent toll-like receptor signaling pathway transmembrane signaling receptor activity signal transduction membrane integral component of membrane toll-like receptor 5 signaling pathway defense response to bacterium innate immune response regulation of cytokine secretion uc287oqe.1 uc287oqe.2 
ENSMUST00000191822.2 Gm38169 ENSMUST00000191822.2 Gm38169 (from geneSymbol) ENSMUST00000191822.1 LF193047 uc287oiw.1 uc287oiw.2 uc287oiw.1 uc287oiw.2 
ENSMUST00000191824.3 4632432E15Rik ENSMUST00000191824.3 4632432E15Rik (from geneSymbol) AK014604 ENSMUST00000191824.1 ENSMUST00000191824.2 uc290dvj.1 uc290dvj.2 uc290dvj.1 uc290dvj.2 
ENSMUST00000191827.2 Gm37396 ENSMUST00000191827.2 Gm37396 (from geneSymbol) ENSMUST00000191827.1 uc287lho.1 uc287lho.2 uc287lho.1 uc287lho.2 
ENSMUST00000191829.2 Dchs2 ENSMUST00000191829.2 dachsous cadherin related 2 (from RefSeq NM_001357165.2) A0A0A6YW72 A0A0A6YW72_MOUSE Dchs2 ENSMUST00000191829.1 NM_001357165 uc290gez.1 uc290gez.2 calcium ion binding plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane nephron development condensed mesenchymal cell proliferation cell-cell adhesion uc290gez.1 uc290gez.2 
ENSMUST00000191831.2 4930420N18Rik ENSMUST00000191831.2 4930420N18Rik (from geneSymbol) AK015169 ENSMUST00000191831.1 uc287hrd.1 uc287hrd.2 uc287hrd.1 uc287hrd.2 
ENSMUST00000191834.2 Gm37756 ENSMUST00000191834.2 Gm37756 (from geneSymbol) ENSMUST00000191834.1 uc287nwt.1 uc287nwt.2 uc287nwt.1 uc287nwt.2 
ENSMUST00000191840.2 Gm37846 ENSMUST00000191840.2 Gm37846 (from geneSymbol) DQ562329 ENSMUST00000191840.1 uc290eyt.1 uc290eyt.2 uc290eyt.1 uc290eyt.2 
ENSMUST00000191849.6 Gm42417 ENSMUST00000191849.6 Gm42417 (from geneSymbol) Ankrd23 BC022973 ENSMUST00000191849.1 ENSMUST00000191849.2 ENSMUST00000191849.3 ENSMUST00000191849.4 ENSMUST00000191849.5 Gm42417 Q8K1D0 Q8K1D0_MOUSE uc007aqn.1 uc007aqn.2 uc007aqn.3 nucleus regulation of transcription from RNA polymerase II promoter titin binding RNA polymerase II sequence-specific DNA binding transcription factor binding uc007aqn.1 uc007aqn.2 uc007aqn.3 
ENSMUST00000191850.2 Gm38070 ENSMUST00000191850.2 Gm38070 (from geneSymbol) AB349884 ENSMUST00000191850.1 uc287hpn.1 uc287hpn.2 uc287hpn.1 uc287hpn.2 
ENSMUST00000191852.2 ENSMUSG00000121763 ENSMUST00000191852.2 ENSMUSG00000121763 (from geneSymbol) BC085271 ENSMUST00000191852.1 uc287oqj.1 uc287oqj.2 uc287oqj.1 uc287oqj.2 
ENSMUST00000191854.6 Pcdh15 ENSMUST00000191854.6 protocadherin 15, transcript variant L (from RefSeq NM_001142760.1) D6RCH0 E9Q7D7 E9Q7R1 E9Q7R2 ENSMUST00000191854.1 ENSMUST00000191854.2 ENSMUST00000191854.3 ENSMUST00000191854.4 ENSMUST00000191854.5 F6KJX4 F6KKG6 F6R5Z7 F6RBV2 F6U3Q6 F6UPC9 F6VPR3 F6WUN7 F6X715 F6XPA1 F6Y0A5 F6YP25 F6YZQ9 F7ASH0 F7CIN1 F7D5J8 F7DFU0 F8VQ61 H3BKS0 NM_001142760 PCD15_MOUSE Q0ZM15 Q0ZM16 Q0ZM18 Q0ZM19 Q0ZM20 Q0ZM21 Q0ZM22 Q0ZM23 Q0ZM24 Q0ZM25 Q0ZM26 Q0ZM27 Q0ZM28 Q0ZM29 Q0ZM30 Q0ZM31 Q0ZM32 Q0ZM33 Q0ZM34 Q0ZM35 Q0ZM37 Q2VQG7 Q3URZ1 Q3UTS7 Q99PJ1 uc033fqh.1 uc033fqh.2 uc033fqh.3 uc033fqh.4 Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function. Antiparallel heterodimer with CDH23 (PubMed:23135401, PubMed:17805295). Found in a complex with TMIE and LHFPL5 (PubMed:25467981). Interacts with LHFPL5/TMHS; this interaction is required for efficient localization to hair bundles (PubMed:23217710). Interacts with MYO7A (PubMed:16481439). Interacts with USH1G; this interaction may recruit USH1G to the plasma membrane (PubMed:21436032). Interacts with TOMT (PubMed:28504928). Isoforms CD1 and CD3 interact with TMC1 (via N-terminus) and TMC2 (via N-terminus) (PubMed:25114259). Q99PJ1; Q99PF4-1: Cdh23; NbExp=10; IntAct=EBI-6556746, EBI-15656347; Q99PJ1; Q9ES64: Ush1c; NbExp=3; IntAct=EBI-6556746, EBI-7418968; Q99PJ1; Q9ES64-3: Ush1c; NbExp=2; IntAct=EBI-6556746, EBI-7418919; Cell membrane ingle-pass membrane protein Note=Efficient localization to the plasma membrane requires the presence of LHFPL5. [Isoform 1]: Cell membrane ; Single- pass type I membrane protein [Isoform 2]: Cell membrane ; Single- pass type I membrane protein [Isoform 3]: Secreted [Isoform 4]: Cell membrane ; Single- pass type I membrane protein [Isoform 5]: Cell membrane ; Single- pass type I membrane protein [Isoform 6]: Cell membrane ; Single- pass type I membrane protein [Isoform 7]: Cell membrane ; Single- pass type I membrane protein [Isoform 8]: Cell membrane ; Single- pass type I membrane protein [Isoform 9]: Cell membrane ; Single- pass type I membrane protein [Isoform 10]: Cell membrane ; Single-pass type I membrane protein [Isoform 11]: Cell membrane ; Single-pass type I membrane protein [Isoform 12]: Cell membrane ; Single-pass type I membrane protein [Isoform 13]: Secreted [Isoform 14]: Secreted [Isoform 15]: Secreted [Isoform 16]: Secreted [Isoform 17]: Secreted [Isoform 18]: Cell membrane ; Single-pass type I membrane protein [Isoform 19]: Cell membrane ; Single-pass type I membrane protein [Isoform 21]: Secreted [Isoform 22]: Secreted [Isoform 23]: Secreted Event=Alternative splicing; Named isoforms=26; Name=1; Synonyms=CD1-1; IsoId=Q99PJ1-1; Sequence=Displayed; Name=2; Synonyms=CD1-2; IsoId=Q99PJ1-2; Sequence=VSP_046580; Name=3; Synonyms=CD1-3/5; IsoId=Q99PJ1-3; Sequence=VSP_046580, VSP_046592, VSP_046594; Name=4; Synonyms=CD1-4; IsoId=Q99PJ1-4; Sequence=VSP_046580, VSP_046602; Name=5; Synonyms=CD1-6; IsoId=Q99PJ1-5; Sequence=VSP_046580, VSP_046591; Name=6; Synonyms=CD1-7; IsoId=Q99PJ1-6; Sequence=VSP_046580, VSP_046601, VSP_046602; Name=7; Synonyms=CD1-8; IsoId=Q99PJ1-7; Sequence=VSP_046580, VSP_046581, VSP_046601, VSP_046602; Name=8; Synonyms=CD1-9; IsoId=Q99PJ1-8; Sequence=VSP_046579; Name=9; Synonyms=CD1-10; IsoId=Q99PJ1-9; Sequence=VSP_046579, VSP_046601; Name=10; Synonyms=CD2-1; IsoId=Q99PJ1-10; Sequence=VSP_046588, VSP_046605; Name=11; Synonyms=CD2-2; IsoId=Q99PJ1-11; Sequence=VSP_046580, VSP_046607, VSP_046609; Name=12; Synonyms=CD2-3; IsoId=Q99PJ1-12; Sequence=VSP_046577, VSP_046588, VSP_046607, VSP_046609; Name=13; Synonyms=CD2-4; IsoId=Q99PJ1-13; Sequence=VSP_046580, VSP_046582, VSP_046583; Name=14; Synonyms=CD2-5; IsoId=Q99PJ1-14; Sequence=VSP_046580, VSP_046584, VSP_046585; Name=15; Synonyms=CD2-6; IsoId=Q99PJ1-15; Sequence=VSP_046580, VSP_046587, VSP_046593; Name=16; Synonyms=CD2-7; IsoId=Q99PJ1-16; Sequence=VSP_046580, VSP_046590, VSP_046596; Name=17; Synonyms=CD2-8; IsoId=Q99PJ1-17; Sequence=VSP_046580, VSP_046595, VSP_046597; Name=18; Synonyms=CD3-1; IsoId=Q99PJ1-18; Sequence=VSP_046606, VSP_046611; Name=19; Synonyms=CD3-2; IsoId=Q99PJ1-19; Sequence=VSP_046580, VSP_046606, VSP_046611; Name=20; Synonyms=CD3-3; IsoId=Q99PJ1-20; Sequence=VSP_046576, VSP_046600, VSP_046610; Name=21; Synonyms=SI-1; IsoId=Q99PJ1-21; Sequence=VSP_046598, VSP_046599; Name=22; Synonyms=SI-2; IsoId=Q99PJ1-22; Sequence=VSP_046580, VSP_046598, VSP_046599; Name=23; Synonyms=SI-3; IsoId=Q99PJ1-23; Sequence=VSP_046580, VSP_046589, VSP_046598, VSP_046599; Name=24; Synonyms=C; IsoId=Q99PJ1-24; Sequence=VSP_046578, VSP_046608; Name=25; IsoId=Q99PJ1-25; Sequence=VSP_046603; Name=26; IsoId=Q99PJ1-26; Sequence=VSP_046601, VSP_046604; Expressed in brain and sensory epithelium of the developing inner ear. Expressed in the retina, in the photoreceptor inner segments, the outer plexiform layer, the inner nuclei layer and the ganglion cell layer and, more diffusely in the inner plexiform layer (at protein level). Not detected in the retinal pigment epithelium (at protein level). Expressed in the spleen, dorsal root ganglion, dorsal aspect of neural tube, floor plate and ependymal cells adjacent to the neural canal. Highest level of expression is detected at embryonic day 16. Alternative splicing isoforms have different spatiotemporal expression patterns. In cochlear cultures at the equivalent of postnatal day 3, isoforms belonging to the CD1 (isoforms 1 through 9) and CD3 (isoforms 18 through 20) groups are highly expressed in hair bundles in the basal coils and moderately in those in the middle of the apical coil; they are hardly detectable in those at the apical end of the apical coil (at protein level). At the base of the cultured cochlea, in the more mature hair bundles, CD3 group isoforms are restricted to the tips of the shorter stereocilia in both inner and outer hair cells. By contrast, at the same stage, isoforms belonging to the CD2 group (isoforms 10 through 17) are highly expressed in hair bundles in the apex of the cochlea and, at lower levels, in those in the middle of the apical coil; they are hardly detectable at the base of the cochlea (at protein level). In mature hair bundles, CD1 group isoforms are distributed fairly evenly along most of the length of the stereocilia on auditory hair cells, whereas they are concentrated toward the upper third of the hair bundle in vestibular hair cells. In both the auditory and the vestibular organs, these isoforms are excluded from a region at the very tip of each stereocilium (at protein level). In contrast, CD2 group isoforms are undetectable in adult cochlear hair cells (at protein level). These isoforms are expressed in the entire hair bundle of the immature cells in the sensory epithelium of the early postnatal vestibule and only in the kinocilium in the more mature hair bundles (at protein level). CD3 group isoforms are detected in immature vestibular hair bundles, concentrated toward the tip of each stereocilium, as early as 15.5 dpc. They also localize to the tips of the shorter stereocilia in the mature vestibular hair bundles and are not detected at the tips of the stereocilia in the tallest row (at protein level). Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic interaction with CDH23. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Note=Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia. [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. [Isoform 13]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. [Isoform 24]: Produced by aberrant splicing sites. Sequence=ABC79270.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; photoreceptor outer segment startle response morphogenesis of an epithelium calcium ion binding protein binding extracellular region extracellular space cytoplasm plasma membrane integral component of plasma membrane actin filament organization cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules visual perception sensory perception of sound locomotory behavior adult walking behavior membrane integral component of membrane stereocilium stereocilium bundle multicellular organism growth auditory receptor cell differentiation macromolecular complex binding synapse photoreceptor cell maintenance protein N-terminus binding inner ear development detection of mechanical stimulus involved in sensory perception of sound sensory perception of light stimulus equilibrioception detection of mechanical stimulus involved in equilibrioception actin filament bundle assembly response to calcium ion righting reflex auditory receptor cell stereocilium organization inner ear receptor stereocilium organization non-motile cilium assembly uc033fqh.1 uc033fqh.2 uc033fqh.3 uc033fqh.4 
ENSMUST00000191856.2 Gm31326 ENSMUST00000191856.2 Gm31326 (from geneSymbol) ENSMUST00000191856.1 uc292kce.1 uc292kce.2 uc292kce.1 uc292kce.2 
ENSMUST00000191857.2 Gm37884 ENSMUST00000191857.2 Gm37884 (from geneSymbol) AK039702 ENSMUST00000191857.1 uc287joe.1 uc287joe.2 uc287joe.1 uc287joe.2 
ENSMUST00000191858.2 Gm38134 ENSMUST00000191858.2 Gm38134 (from geneSymbol) ENSMUST00000191858.1 uc292lax.1 uc292lax.2 uc292lax.1 uc292lax.2 
ENSMUST00000191861.2 Ighv1-24 ENSMUST00000191861.2 Ighv1-24 (from geneSymbol) A0A0A6YY24 A0A0A6YY24_MOUSE ENSMUST00000191861.1 Ighv1-24 uc288jyp.1 uc288jyp.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jyp.1 uc288jyp.2 
ENSMUST00000191862.6 Ighv1-36 ENSMUST00000191862.6 Ighv1-36 (from geneSymbol) A0A0A6YXT2 A0A0A6YXT2_MOUSE AY704180 ENSMUST00000191862.1 ENSMUST00000191862.2 ENSMUST00000191862.3 ENSMUST00000191862.4 ENSMUST00000191862.5 Ighv1-36 uc288jzd.1 uc288jzd.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jzd.1 uc288jzd.2 
ENSMUST00000191863.2 Gm37661 ENSMUST00000191863.2 Gm37661 (from geneSymbol) AK051148 ENSMUST00000191863.1 uc292jwn.1 uc292jwn.2 uc292jwn.1 uc292jwn.2 
ENSMUST00000191866.2 Gm37055 ENSMUST00000191866.2 Gm37055 (from geneSymbol) AK210842 ENSMUST00000191866.1 uc287pbc.1 uc287pbc.2 uc287pbc.1 uc287pbc.2 
ENSMUST00000191867.2 Gm49885 ENSMUST00000191867.2 Gm49885 (from geneSymbol) ENSMUST00000191867.1 uc291duf.1 uc291duf.2 uc291duf.1 uc291duf.2 
ENSMUST00000191868.2 Ighv1-42 ENSMUST00000191868.2 Ighv1-42 (from geneSymbol) A0A0A6YY38 A0A0A6YY38_MOUSE ENSMUST00000191868.1 Ighv1-42 U91317 uc288jzl.1 uc288jzl.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jzl.1 uc288jzl.2 
ENSMUST00000191873.2 Gm37242 ENSMUST00000191873.2 Gm37242 (from geneSymbol) AK155013 ENSMUST00000191873.1 uc287ibd.1 uc287ibd.2 uc287ibd.1 uc287ibd.2 
ENSMUST00000191875.2 Gm37942 ENSMUST00000191875.2 Gm37942 (from geneSymbol) BC114596 ENSMUST00000191875.1 uc287pdp.1 uc287pdp.2 uc287pdp.1 uc287pdp.2 
ENSMUST00000191877.2 Gm38114 ENSMUST00000191877.2 Gm38114 (from geneSymbol) ENSMUST00000191877.1 LF204861 uc291fvy.1 uc291fvy.2 uc291fvy.1 uc291fvy.2 
ENSMUST00000191880.3 4930517L18Rik ENSMUST00000191880.3 4930517L18Rik (from geneSymbol) AK019682 ENSMUST00000191880.1 ENSMUST00000191880.2 uc289oua.1 uc289oua.2 uc289oua.3 uc289oua.1 uc289oua.2 uc289oua.3 
ENSMUST00000191884.2 Gm38359 ENSMUST00000191884.2 Gm38359 (from geneSymbol) AK048058 ENSMUST00000191884.1 uc287oor.1 uc287oor.2 uc287oor.1 uc287oor.2 
ENSMUST00000191887.2 Gm37663 ENSMUST00000191887.2 Gm37663 (from geneSymbol) ENSMUST00000191887.1 uc292iop.1 uc292iop.2 uc292iop.1 uc292iop.2 
ENSMUST00000191888.2 Gm37075 ENSMUST00000191888.2 Gm37075 (from geneSymbol) ENSMUST00000191888.1 uc292snt.1 uc292snt.2 uc292snt.1 uc292snt.2 
ENSMUST00000191892.2 4932442E05Rik ENSMUST00000191892.2 4932442E05Rik (from geneSymbol) AK016565 ENSMUST00000191892.1 uc287vde.1 uc287vde.2 uc287vde.1 uc287vde.2 
ENSMUST00000191894.2 D930036K23Rik ENSMUST00000191894.2 D930036K23Rik (from geneSymbol) AK043016 ENSMUST00000191894.1 uc289tes.1 uc289tes.2 uc289tes.1 uc289tes.2 
ENSMUST00000191895.2 Gm37912 ENSMUST00000191895.2 Gm37912 (from geneSymbol) ENSMUST00000191895.1 uc287ouo.1 uc287ouo.2 uc287ouo.1 uc287ouo.2 
ENSMUST00000191896.6 Zc3h11a ENSMUST00000191896.6 zinc finger CCCH type containing 11A, transcript variant 2 (from RefSeq NM_144530.6) ENSMUST00000191896.1 ENSMUST00000191896.2 ENSMUST00000191896.3 ENSMUST00000191896.4 ENSMUST00000191896.5 Kiaa0663 NM_144530 Q6NXW9 Q6NZF1 Q6PDR6 Q80TU7 Q8C5L5 Q99JN6 ZC11A_MOUSE uc007cqo.1 uc007cqo.2 uc007cqo.3 uc007cqo.4 Involved in nuclear mRNA export; probably mediated by association with the TREX complex. Interacts with THOC2, DDX39 and POLDIP3; the interactions are ATP-dependent and indicative for an association with the TREX complex. Sequence=AAH58552.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAC37127.1; Type=Frameshift; Evidence=; Sequence=BAC65623.4; Type=Erroneous initiation; Evidence=; mRNA binding cell poly(A)+ mRNA export from nucleus metal ion binding mRNA transport transcription export complex uc007cqo.1 uc007cqo.2 uc007cqo.3 uc007cqo.4 
ENSMUST00000191899.6 Dag1 ENSMUST00000191899.6 dystroglycan 1, transcript variant 6 (from RefSeq NM_001276486.1) DAG1_MOUSE Dag1 ENSMUST00000191899.1 ENSMUST00000191899.2 ENSMUST00000191899.3 ENSMUST00000191899.4 ENSMUST00000191899.5 NM_001276486 Q61094 Q61141 Q61497 Q62165 uc009roz.1 uc009roz.2 uc009roz.3 uc009roz.4 This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. A complete lack of the encoded protein in mice results in embryonic lethality due to the disorganization of Reichert's membrane. Chimeric mice deficient in the encoded protein overcome embryonic lethality but develop a progressive muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]. The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity). [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity (By similarity). Monomer. Heterodimer of alpha- and beta-dystroglycan subunits which are the central components of the dystrophin-glycoprotein complex. This complex then can form a dystrophin-associated glycoprotein complex (DGC) which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex. Interacts (via the N-terminal of alphaDAG1) with LARGE1; the interaction enhances laminin binding (By similarity). Interacts with SGCD. Interacts with AGR2 and AGR3. Interacts (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif. Interacts (betaDAG1, via its PPXY motif) with UTRN (via its WWW and ZZ domains); the interaction is inhibited by phosphorylation on the PPXY motif. Interacts (betaDAG1, via its phosphorylated PPXY motif) with the SH2 domain-containing proteins, FYN, CSK, NCK and SHC. Interacts (betaDAG1) with CAV3 (via a central WW-like domain); the interaction disrupts the binding of DMD. BetaDAG1 directly interacts with ANK3, but not with ANK2; this interaction does not interfere with DMD-binding and is required for retention at costameres (By similarity). Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (PubMed:11430802). Interacts with POMGNT1 (By similarity). PRO_0000021067; Q4VBE4: Egflam; NbExp=2; IntAct=EBI-2025154, EBI-2025048; [Alpha-dystroglycan]: Secreted, extracellular space [Beta-dystroglycan]: Cell membrane ; Single-pass type I membrane protein Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Cell membrane, sarcolemma. Postsynaptic cell membrane. Note=The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs). In adult muscle, NMJ localization depends upon ANK2 presence, but not in newborn animals. In peripheral nerves, localizes to the Schwann cell membrane. Colocalizes with ERM proteins in Schwann-cell microvilli. Detected in brain and kidney (at protein level) (PubMed:16709410). Detected in sciatic nerve (at protein level) (PubMed:11430802). Expressed in neurons and muscle cells (at protein level) (PubMed:25757569). Expressed in a variety of tissues. In brain, expressed in the hippocampal formation, the olfactory bulb, the cerebellum and the thalamus. In the peripheral nerve system, expressed in Schwann cells. Broadly expressed in late embryonic and early postnatal cerebellar neurons, including premigratory granule neurons of the external granule cell layer, but expression is largely down- regulated. Weak expression in Purkinje cells throughout development. Alpha- and beta-DG proteins are also present on the Bergmann glial scaffolds used by granule cells during early postnatal radial migration. In the peripheral nerve system, expression briefly precedes and parallels myelination. First expressed at 18.5 dpc in spinal roots, dorsal root ganglions and nerve trunks. At P1, at the onset of myelination, expressed in motor roots. At P5 and P15, expression progressively increases in sensory roots and peripheral nerves. Between postnatal 2 weeks and 18 months, localizes at the nodes of Ranvier as well as at the Schwann cell outer membrane. [Alpha-dystroglycan]: O-glycosylated (PubMed:20044576). POMGNT1 catalyzes the initial addition of N-acetylglucosamine, giving rise to the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety and thus providing the necessary basis for the addition of further carbohydrate moieties. Heavily O-glycosylated comprising of up to two thirds of its mass and the carbohydrate composition differs depending on tissue type. Mucin- type O-glycosylation is important for ligand binding activity. O- mannosylation is found in high abundance in both brain and muscle where the most abundant glycan is Sia-alpha-2-3-Gal-beta-1-4-Glc-NAc-beta-1- 2-Man. In muscle, glycosylation on Thr-315, Thr-317, Thr-379 by a phosphorylated O-mannosyl glycan with the structure 2-(N-acetylamido)- 2-deoxygalactosyl-beta-1,3-2-(N-acetylamido)-2-deoxyglucosyl-beta-1,4- 6-phosphomannose is mediated by like-acetylglucosaminyltransferase (LARGE1) protein amd is required for laminin binding. O-glycosylated in the N-terminal region with a core 1 or possibly core 8 glycan. The brain form displays a unique glycosylation pattern which is absent in other tissues; this form shows enhanced binding to laminin LAMA5 compared to the skeletal muscle form (By similarity). [Beta-dystroglycan]: N-glycosylated. Autolytic cleavage produces the alpha and beta subunits. In cutaneous cells, as well as in certain pathological conditions, shedding of beta-dystroglycan can occur releasing a peptide of about 30 kDa (By similarity). SRC-mediated phosphorylation of the PPXY motif of the beta subunit recruits SH2 domain-containing proteins, but inhibits binding to WWW domain-containing proteins, DMD and UTRN. This phosphorylation also inhibits nuclear entry (By similarity). Homozygous null mice embryos exhibit gross developmental abnormalities, beginning around 6.5 days of gestation, in the Reichert's membrane, an extraembryonic basement membrane. In peripheral nerves, ablation of DAG1 from 4 week-old mice causes abnormalities in nerve structure and function including mildly impaired sorting of axons, dysmyelination, axonal loss and aberrant nerve conduction. Laminin-binding is lost and there is disruption of the Schwann cell dystroglycan complex. positive regulation of cell-matrix adhesion morphogenesis of an epithelial sheet dystroglycan binding actin binding calcium ion binding protein binding extracellular region basement membrane extracellular space nucleus nucleoplasm cytoplasm cytoskeleton plasma membrane cell-cell junction cell-cell adherens junction focal adhesion membrane protein ectodomain proteolysis cytoskeletal anchoring at plasma membrane aging structural constituent of muscle external side of plasma membrane regulation of gastrulation regulation of epithelial to mesenchymal transition Schwann cell differentiation Schwann cell development response to denervation involved in regulation of muscle adaptation tubulin binding dystrophin-associated glycoprotein complex dystroglycan complex membrane integral component of membrane viral process basolateral plasma membrane calcium-dependent cell-matrix adhesion vinculin binding modulation by virus of host morphology or physiology nerve development nerve maturation myelination in peripheral nervous system lamellipodium cell junction filopodium negative regulation of cell migration axon regeneration positive regulation of myelination node of Ranvier nuclear periphery microtubule anchoring SH2 domain binding sarcolemma costamere laminin binding laminin-1 binding skeletal muscle tissue regeneration negative regulation of MAPK cascade response to peptide hormone plasma membrane raft membrane raft synapse postsynaptic membrane positive regulation of protein kinase activity positive regulation of oligodendrocyte differentiation regulation of synapse organization alpha-actinin binding negative regulation of protein kinase B signaling angiogenesis involved in wound healing epithelial tube branching involved in lung morphogenesis branching involved in salivary gland morphogenesis contractile ring cellular response to mechanical stimulus cellular response to cholesterol commissural neuron axon guidance basement membrane organization retrograde trans-synaptic signaling by trans-synaptic protein complex glutamatergic synapse GABA-ergic synapse postsynaptic cytosol positive regulation of basement membrane assembly involved in embryonic body morphogenesis uc009roz.1 uc009roz.2 uc009roz.3 uc009roz.4 
ENSMUST00000191902.2 Gm37099 ENSMUST00000191902.2 Gm37099 (from geneSymbol) ENSMUST00000191902.1 uc287mdr.1 uc287mdr.2 uc287mdr.1 uc287mdr.2 
ENSMUST00000191908.2 9430083B18Rik ENSMUST00000191908.2 9430083B18Rik (from geneSymbol) AK020503 ENSMUST00000191908.1 uc287nzm.1 uc287nzm.2 uc287nzm.1 uc287nzm.2 
ENSMUST00000191912.2 Gm34294 ENSMUST00000191912.2 Gm34294 (from geneSymbol) AK035492 ENSMUST00000191912.1 uc290cvy.1 uc290cvy.2 uc290cvy.1 uc290cvy.2 
ENSMUST00000191913.2 D630023O14Rik ENSMUST00000191913.2 D630023O14Rik (from geneSymbol) AK052761 ENSMUST00000191913.1 uc287nix.1 uc287nix.2 uc287nix.1 uc287nix.2 
ENSMUST00000191914.2 Gm37398 ENSMUST00000191914.2 Gm37398 (from geneSymbol) ENSMUST00000191914.1 uc290ell.1 uc290ell.2 uc290ell.1 uc290ell.2 
ENSMUST00000191917.2 Gm37026 ENSMUST00000191917.2 Gm37026 (from geneSymbol) ENSMUST00000191917.1 uc289wsu.1 uc289wsu.2 uc289wsu.1 uc289wsu.2 
ENSMUST00000191918.2 Ighv6-4 ENSMUST00000191918.2 Ighv6-4 (from geneSymbol) A0A0A6YX19 A0A0A6YX19_MOUSE ENSMUST00000191918.1 Ighv6-4 uc288jwu.1 uc288jwu.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jwu.1 uc288jwu.2 
ENSMUST00000191922.2 Gm37926 ENSMUST00000191922.2 Gm37926 (from geneSymbol) ENSMUST00000191922.1 uc290fmz.1 uc290fmz.2 uc290fmz.1 uc290fmz.2 
ENSMUST00000191927.2 Gm10576 ENSMUST00000191927.2 Gm10576 (from geneSymbol) AK157058 ENSMUST00000191927.1 uc290obf.1 uc290obf.2 uc290obf.1 uc290obf.2 
ENSMUST00000191930.2 Gm37496 ENSMUST00000191930.2 Gm37496 (from geneSymbol) AK081380 ENSMUST00000191930.1 uc288iwt.1 uc288iwt.2 uc288iwt.1 uc288iwt.2 
ENSMUST00000191938.2 Gm37141 ENSMUST00000191938.2 Gm37141 (from geneSymbol) ENSMUST00000191938.1 uc290scf.1 uc290scf.2 uc290scf.1 uc290scf.2 
ENSMUST00000191944.2 Gm38210 ENSMUST00000191944.2 Gm38210 (from geneSymbol) ENSMUST00000191944.1 uc287nks.1 uc287nks.2 uc287nks.1 uc287nks.2 
ENSMUST00000191945.2 Gm38387 ENSMUST00000191945.2 Gm38387 (from geneSymbol) ENSMUST00000191945.1 uc287ixf.1 uc287ixf.2 uc287ixf.1 uc287ixf.2 
ENSMUST00000191950.2 Gm37866 ENSMUST00000191950.2 Gm37866 (from geneSymbol) ENSMUST00000191950.1 uc289swj.1 uc289swj.2 uc289swj.1 uc289swj.2 
ENSMUST00000191952.2 Jade1 ENSMUST00000191952.2 Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function. (from UniProt Q6ZPI0) AK129445 ENSMUST00000191952.1 JADE1_MOUSE Kiaa1807 Phf17 Q6IE84 Q6ZPI0 Q8C7S6 Q8CFM2 Q8R362 uc290exs.1 uc290exs.2 Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with NPHP4. Nucleus Chromosome Cytoplasm Cytoplasm, cytoskeleton, cilium basal body Note=Localizes to the ciliary transition zone. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Jade1L; IsoId=Q6ZPI0-1; Sequence=Displayed; Name=2; Synonyms=Jade1S; IsoId=Q6ZPI0-2; Sequence=VSP_021048, VSP_021049; Highly expressed in kidney. Also present in liver (at protein level). Expressed from 6.5 dpc. From 12.5 to 15.5 dpc, expressed in the nervous system and developing muscles. The 2 PHD-type zinc fingers are required for transcriptional activity. Mice are viable and fertile, and show no visible phenotype. Belongs to the JADE family. Sequence=AAH26471.1; Type=Erroneous initiation; Evidence=; Sequence=BAC98255.1; Type=Erroneous initiation; Evidence=; histone acetyltransferase complex transcription coactivator activity nucleus cytoplasm cytosol cytoskeleton plasma membrane apoptotic process nuclear speck ciliary basal body cell projection histone H3 acetylation histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K12 acetylation metal ion binding negative regulation of canonical Wnt signaling pathway positive regulation of nucleic acid-templated transcription negative regulation of G1/S transition of mitotic cell cycle histone H4-K16 acetylation uc290exs.1 uc290exs.2 
ENSMUST00000191953.2 Gm38313 ENSMUST00000191953.2 Gm38313 (from geneSymbol) ENSMUST00000191953.1 uc290ggs.1 uc290ggs.2 uc290ggs.1 uc290ggs.2 
ENSMUST00000191960.2 Tdpoz2 ENSMUST00000191960.2 TD and POZ domain containing 2 (from RefSeq NM_001007222.3) A0A0A6YVW8 A0A0A6YVW8_MOUSE ENSMUST00000191960.1 NM_001007222 Tdpoz2 uc008qfl.1 uc008qfl.2 uc008qfl.3 Belongs to the Tdpoz family. uc008qfl.1 uc008qfl.2 uc008qfl.3 
ENSMUST00000191961.2 Gm36990 ENSMUST00000191961.2 Gm36990 (from geneSymbol) AK082112 ENSMUST00000191961.1 uc290ejf.1 uc290ejf.2 uc290ejf.1 uc290ejf.2 
ENSMUST00000191963.2 A130050O07Rik ENSMUST00000191963.2 A130050O07Rik (from geneSymbol) AK037803 ENSMUST00000191963.1 uc287mdy.1 uc287mdy.2 uc287mdy.1 uc287mdy.2 
ENSMUST00000191968.6 Gm38003 ENSMUST00000191968.6 Gm38003 (from geneSymbol) ENSMUST00000191968.1 ENSMUST00000191968.2 ENSMUST00000191968.3 ENSMUST00000191968.4 ENSMUST00000191968.5 uc292sjz.1 uc292sjz.2 uc292sjz.1 uc292sjz.2 
ENSMUST00000191978.2 Gm38127 ENSMUST00000191978.2 Gm38127 (from geneSymbol) ENSMUST00000191978.1 uc292skv.1 uc292skv.2 uc292skv.1 uc292skv.2 
ENSMUST00000191979.2 Gm38075 ENSMUST00000191979.2 Gm38075 (from geneSymbol) ENSMUST00000191979.1 uc287iqk.1 uc287iqk.2 uc287iqk.1 uc287iqk.2 
ENSMUST00000191984.3 Gm43917 ENSMUST00000191984.3 Gm43917 (from geneSymbol) AK089870 ENSMUST00000191984.1 ENSMUST00000191984.2 uc291gmz.1 uc291gmz.2 uc291gmz.1 uc291gmz.2 
ENSMUST00000191986.2 Gm37338 ENSMUST00000191986.2 Gm37338 (from geneSymbol) ENSMUST00000191986.1 uc290drq.1 uc290drq.2 uc290drq.1 uc290drq.2 
ENSMUST00000191987.2 Gm37282 ENSMUST00000191987.2 Gm37282 (from geneSymbol) AK180294 ENSMUST00000191987.1 uc292jxi.1 uc292jxi.2 uc292jxi.1 uc292jxi.2 
ENSMUST00000191988.2 Gm32496 ENSMUST00000191988.2 predicted gene, 32496 (from RefSeq NR_153352.1) ENSMUST00000191988.1 NR_153352 uc290dty.1 uc290dty.2 uc290dty.1 uc290dty.2 
ENSMUST00000191992.2 Gm37047 ENSMUST00000191992.2 Gm37047 (from geneSymbol) ENSMUST00000191992.1 uc287hqw.1 uc287hqw.2 uc287hqw.1 uc287hqw.2 
ENSMUST00000191993.2 Gm37455 ENSMUST00000191993.2 Gm37455 (from geneSymbol) ENSMUST00000191993.1 uc288vob.1 uc288vob.2 uc288vob.1 uc288vob.2 
ENSMUST00000191994.2 Gm37161 ENSMUST00000191994.2 Gm37161 (from geneSymbol) ENSMUST00000191994.1 uc287liu.1 uc287liu.2 uc287liu.1 uc287liu.2 
ENSMUST00000191996.2 Gm37370 ENSMUST00000191996.2 Gm37370 (from geneSymbol) AK156183 ENSMUST00000191996.1 uc287iec.1 uc287iec.2 uc287iec.1 uc287iec.2 
ENSMUST00000192001.6 Camsap2 ENSMUST00000192001.6 calmodulin regulated spectrin-associated protein family, member 2, transcript variant 3 (from RefSeq NM_001347110.1) B7ZNI4 CAMP2_MOUSE Camsap1l1 Camsap2 ENSMUST00000192001.1 ENSMUST00000192001.2 ENSMUST00000192001.3 ENSMUST00000192001.4 ENSMUST00000192001.5 Kiaa1078 NM_001347110 Q80TK8 Q8C1B1 Q8C4J5 uc007cur.1 uc007cur.2 uc007cur.3 uc007cur.4 Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (By similarity). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (By similarity). In addition, it also reduces the velocity of microtubule polymerization (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (By similarity). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non- centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (By similarity). Through the microtubule cytoskeleton, regulates the autophagosome transport (By similarity). Interacts with CAMSAP3 (PubMed:23169647). Interacts with KATNA1 and KATNB1; leading to regulate the length of CAMSAP2-decorated microtubule stretches (By similarity). Interacts with a complex formed by AKAP9 and PDE4DIP isoform 2/MMG8/SMYLE, which recruits CAMSAP2 to the Golgi (By similarity). Interacts with MAPRE1/EB1 (By similarity). Q8C1B1; Q80VC9: Camsap3; NbExp=2; IntAct=EBI-8839434, EBI-2125556; Cytoplasm, cytoskeleton Golgi apparatus Cytoplasm Cytoplasm, cytoskeleton, cilium basal body Note=Associated with the minus-end of microtubules and also detected at the centrosomes. Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound. The length of CAMSAP2-decorated stretches on the minus-end of microtubules is dependent on MAPRE1/EB1 and MAPRE3/EB3, which promote elongation of CAMSAP2-decorated microtubule stretches. Recruited to the Golgi apparatus by AKAP9 and PDE4DIP isoform 2/MMG8/SMYLE. In neurons, localizes to the minus-end of microtubules in axon and dendrites. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C1B1-1; Sequence=Displayed; Name=2; IsoId=Q8C1B1-2; Sequence=VSP_030807; The CKK domain binds microtubules and specifically recognizes the minus-end of microtubules. The MBD (microtubule-binding domain) region can recognize some features of the microtubule lattice, which might contribute to the specific decoration of growing microtubule minus-ends by CAMSAP2. Belongs to the CAMSAP1 family. microtubule cytoskeleton organization protein binding calmodulin binding cytoplasm Golgi apparatus cytosol cytoskeleton microtubule negative regulation of microtubule depolymerization microtubule binding spectrin binding regulation of microtubule polymerization cytoplasmic microtubule organization neuron projection development regulation of organelle organization microtubule minus-end regulation of dendrite development microtubule minus-end binding axon development regulation of Golgi organization microtubule end centrosome uc007cur.1 uc007cur.2 uc007cur.3 uc007cur.4 
ENSMUST00000192003.2 BC037039 ENSMUST00000192003.2 cDNA sequence BC037039 (from RefSeq NR_188883.1) ENSMUST00000192003.1 NR_188883 uc289ouv.1 uc289ouv.2 uc289ouv.1 uc289ouv.2 
ENSMUST00000192004.2 1700016A09Rik ENSMUST00000192004.2 1700016A09Rik (from geneSymbol) AK006008 ENSMUST00000192004.1 uc292dnn.1 uc292dnn.2 uc292dnn.1 uc292dnn.2 
ENSMUST00000192005.2 4930470B04Rik ENSMUST00000192005.2 4930470B04Rik (from geneSymbol) ENSMUST00000192005.1 uc287hle.1 uc287hle.2 uc287hle.1 uc287hle.2 
ENSMUST00000192006.2 Gm37195 ENSMUST00000192006.2 Gm37195 (from geneSymbol) ENSMUST00000192006.1 uc292jtx.1 uc292jtx.2 uc292jtx.1 uc292jtx.2 
ENSMUST00000192008.2 Gm37506 ENSMUST00000192008.2 Gm37506 (from geneSymbol) ENSMUST00000192008.1 LF192626 uc287hjo.1 uc287hjo.2 uc287hjo.1 uc287hjo.2 
ENSMUST00000192012.2 Gm37935 ENSMUST00000192012.2 Gm37935 (from geneSymbol) AK028019 ENSMUST00000192012.1 uc287lww.1 uc287lww.2 uc287lww.1 uc287lww.2 
ENSMUST00000192013.4 Gm38199 ENSMUST00000192013.4 Gm38199 (from geneSymbol) AK149691 ENSMUST00000192013.1 ENSMUST00000192013.2 ENSMUST00000192013.3 uc291otu.1 uc291otu.2 uc291otu.1 uc291otu.2 
ENSMUST00000192016.2 Gm37045 ENSMUST00000192016.2 Gm37045 (from geneSymbol) AK040273 ENSMUST00000192016.1 uc287mfl.1 uc287mfl.2 uc287mfl.1 uc287mfl.2 
ENSMUST00000192022.2 Gm10745 ENSMUST00000192022.2 predicted gene 10745 (from RefSeq NR_040751.1) ENSMUST00000192022.1 NR_040751 uc029ujs.1 uc029ujs.2 uc029ujs.1 uc029ujs.2 
ENSMUST00000192023.2 Gm37175 ENSMUST00000192023.2 Gm37175 (from geneSymbol) ENSMUST00000192023.1 uc289ysc.1 uc289ysc.2 uc289ysc.1 uc289ysc.2 
ENSMUST00000192025.2 Gm37783 ENSMUST00000192025.2 Gm37783 (from geneSymbol) AK032984 ENSMUST00000192025.1 uc287pdv.1 uc287pdv.2 uc287pdv.1 uc287pdv.2 
ENSMUST00000192027.2 Gm38119 ENSMUST00000192027.2 Gm38119 (from geneSymbol) A0A0A6YX29 A0A0A6YX29_MOUSE ENSMUST00000192027.1 Gm38119 uc290hew.1 uc290hew.2 uc290hew.1 uc290hew.2 
ENSMUST00000192030.2 Gm38231 ENSMUST00000192030.2 Gm38231 (from geneSymbol) ENSMUST00000192030.1 uc287qnh.1 uc287qnh.2 uc287qnh.1 uc287qnh.2 
ENSMUST00000192033.2 Gm37076 ENSMUST00000192033.2 Gm37076 (from geneSymbol) AK030243 ENSMUST00000192033.1 uc287krt.1 uc287krt.2 uc287krt.1 uc287krt.2 
ENSMUST00000192036.2 Gm37219 ENSMUST00000192036.2 Gm37219 (from geneSymbol) ENSMUST00000192036.1 LF192829 uc287leb.1 uc287leb.2 uc287leb.1 uc287leb.2 
ENSMUST00000192037.2 Gm38033 ENSMUST00000192037.2 Gm38033 (from geneSymbol) ENSMUST00000192037.1 uc287hhq.1 uc287hhq.2 uc287hhq.1 uc287hhq.2 
ENSMUST00000192038.2 Gm37808 ENSMUST00000192038.2 Gm37808 (from geneSymbol) ENSMUST00000192038.1 uc292ssa.1 uc292ssa.2 uc292ssa.1 uc292ssa.2 
ENSMUST00000192042.2 Gm38373 ENSMUST00000192042.2 Gm38373 (from geneSymbol) ENSMUST00000192042.1 uc291aii.1 uc291aii.2 uc291aii.1 uc291aii.2 
ENSMUST00000192045.2 Gm8797 ENSMUST00000192045.2 Cytoplasm Nucleus (from UniProt A0A0A6YW67) A0A0A6YW67 A0A0A6YW67_MOUSE AK209901 ENSMUST00000192045.1 Gm8797 uc290dsu.1 uc290dsu.2 Cytoplasm Nucleus uc290dsu.1 uc290dsu.2 
ENSMUST00000192050.2 Gm37906 ENSMUST00000192050.2 Gm37906 (from geneSymbol) ENSMUST00000192050.1 LF192602 uc287gzw.1 uc287gzw.2 uc287gzw.1 uc287gzw.2 
ENSMUST00000192052.2 Gm38118 ENSMUST00000192052.2 Gm38118 (from geneSymbol) ENSMUST00000192052.1 uc287pdh.1 uc287pdh.2 uc287pdh.1 uc287pdh.2 
ENSMUST00000192053.2 Gm37401 ENSMUST00000192053.2 Gm37401 (from geneSymbol) ENSMUST00000192053.1 uc292ldc.1 uc292ldc.2 uc292ldc.1 uc292ldc.2 
ENSMUST00000192059.2 Gm37500 ENSMUST00000192059.2 Gm37500 (from geneSymbol) ENSMUST00000192059.1 uc290hpa.1 uc290hpa.2 uc290hpa.1 uc290hpa.2 
ENSMUST00000192062.2 Gm37292 ENSMUST00000192062.2 Gm37292 (from geneSymbol) AK141529 ENSMUST00000192062.1 uc291oet.1 uc291oet.2 uc291oet.1 uc291oet.2 
ENSMUST00000192063.2 Gm38309 ENSMUST00000192063.2 Gm38309 (from geneSymbol) ENSMUST00000192063.1 uc289tow.1 uc289tow.2 uc289tow.1 uc289tow.2 
ENSMUST00000192064.2 Gm37946 ENSMUST00000192064.2 Gm37946 (from geneSymbol) ENSMUST00000192064.1 uc289esn.1 uc289esn.2 uc289esn.1 uc289esn.2 
ENSMUST00000192066.2 Gm37867 ENSMUST00000192066.2 Gm37867 (from geneSymbol) AK133533 ENSMUST00000192066.1 uc290egb.1 uc290egb.2 uc290egb.1 uc290egb.2 
ENSMUST00000192069.6 Tnr ENSMUST00000192069.6 tenascin R (from RefSeq NM_022312.3) A2RT70 ENSMUST00000192069.1 ENSMUST00000192069.2 ENSMUST00000192069.3 ENSMUST00000192069.4 ENSMUST00000192069.5 NM_022312 O88717 Q8BYI9 TENR_MOUSE uc007dea.1 uc007dea.2 uc007dea.3 uc007dea.4 Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediates inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity). Interacts with BCAN and ACAN in a calcium-dependent manner. Interacts with SCN2B, PTPRZ1, and CSPG3 (By similarity). Forms oligomers. Isoforms 1 and 2 form respectively trimeric (tribrachion) and dimeric kink-armed rodlike structures, which are linked by disulfide bridges. Interacts with CNTN1, TNC and FN1. Secreted, extracellular space, extracellular matrix. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=J1-180, TN-R 180; IsoId=Q8BYI9-1; Sequence=Displayed; Name=2; Synonyms=J1-160, TN-R 160; IsoId=Q8BYI9-2; Sequence=VSP_012994; Brain-specific. Isoform 1 is barely detectable at 17 dpc and increases in intensity until postnatal day 15, when it reaches adult levels. Isoform 2 is detectable from postnatal day 5 and reaches adult levels also at postnatal day 15. The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B (By similarity). Contains N-linked oligosaccharides with a sulfated carbohydrate structures (By similarity). Contains N-linked oligosaccharides, O- linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Knockout mice display alterations of the extracellular matrix, and decreased axonal conduction velocities in the CNS. Belongs to the tenascin family. integrin binding extracellular region cell adhesion neuron cell-cell adhesion negative regulation of cell adhesion associative learning cell surface negative regulation of neuron projection development telencephalon cell migration negative regulation of cell-cell adhesion extracellular matrix organization negative regulation of axon extension extracellular matrix locomotory exploration behavior membrane raft sphingolipid binding negative regulation of axon extension involved in regeneration regulation of neurogenesis modulation of synaptic transmission negative regulation of synaptic transmission synapse organization neuromuscular process controlling balance positive regulation of synaptic transmission, glutamatergic positive regulation of transmission of nerve impulse long-term synaptic potentiation perineuronal net perisynaptic extracellular matrix glutamatergic synapse uc007dea.1 uc007dea.2 uc007dea.3 uc007dea.4 
ENSMUST00000192072.2 Gm37648 ENSMUST00000192072.2 Gm37648 (from geneSymbol) AK155161 ENSMUST00000192072.1 uc287mvl.1 uc287mvl.2 uc287mvl.1 uc287mvl.2 
ENSMUST00000192073.2 Gm36638 ENSMUST00000192073.2 Gm36638 (from geneSymbol) ENSMUST00000192073.1 uc288ppu.1 uc288ppu.2 uc288ppu.1 uc288ppu.2 
ENSMUST00000192076.3 Taf1a ENSMUST00000192076.3 TATA-box binding protein associated factor, RNA polymerase I, A, transcript variant 1 (from RefSeq NM_021466.4) ENSMUST00000192076.1 ENSMUST00000192076.2 NM_021466 P97357 TAF1A_MOUSE uc287orh.1 uc287orh.2 Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with UBFT (By similarity). Interacts with CEBPA (isoform 1 and isoform 4) (By similarity). Nucleus RNA polymerase I transcription factor complex DNA binding protein binding nucleus nucleoplasm transcription from RNA polymerase I promoter microtubule cytoskeleton uc287orh.1 uc287orh.2 
ENSMUST00000192077.2 Ighv1-15 ENSMUST00000192077.2 Ighv1-15 (from geneSymbol) A0A0A6YXA5 A0A0A6YXA5_MOUSE ENSMUST00000192077.1 Ighv1-15 uc288jxz.1 uc288jxz.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jxz.1 uc288jxz.2 
ENSMUST00000192078.2 Gm37435 ENSMUST00000192078.2 Gm37435 (from geneSymbol) ENSMUST00000192078.1 uc287hqc.1 uc287hqc.2 uc287hqc.1 uc287hqc.2 
ENSMUST00000192079.2 Gm37649 ENSMUST00000192079.2 Gm37649 (from geneSymbol) AK140512 ENSMUST00000192079.1 uc057ceg.1 uc057ceg.2 uc057ceg.1 uc057ceg.2 
ENSMUST00000192082.2 1110025M09Rik ENSMUST00000192082.2 1110025M09Rik (from geneSymbol) AK003925 ENSMUST00000192082.1 uc288zxo.1 uc288zxo.2 uc288zxo.1 uc288zxo.2 
ENSMUST00000192083.2 Gm38200 ENSMUST00000192083.2 Gm38200 (from geneSymbol) ENSMUST00000192083.1 uc290fdd.1 uc290fdd.2 uc290fdd.1 uc290fdd.2 
ENSMUST00000192085.2 Gm38128 ENSMUST00000192085.2 Gm38128 (from geneSymbol) AK136983 ENSMUST00000192085.1 uc290ezf.1 uc290ezf.2 uc290ezf.1 uc290ezf.2 
ENSMUST00000192087.2 Gm10851 ENSMUST00000192087.2 Gm10851 (from geneSymbol) AK153745 ENSMUST00000192087.1 uc289tap.1 uc289tap.2 uc289tap.1 uc289tap.2 
ENSMUST00000192088.2 Gm37503 ENSMUST00000192088.2 Gm37503 (from geneSymbol) AK212476 ENSMUST00000192088.1 uc287jdt.1 uc287jdt.2 uc287jdt.1 uc287jdt.2 
ENSMUST00000192097.2 Gm38256 ENSMUST00000192097.2 Gm38256 (from geneSymbol) ENSMUST00000192097.1 uc287mxm.1 uc287mxm.2 uc287mxm.1 uc287mxm.2 
ENSMUST00000192101.6 Gm37875 ENSMUST00000192101.6 Gm37875 (from geneSymbol) ENSMUST00000192101.1 ENSMUST00000192101.2 ENSMUST00000192101.3 ENSMUST00000192101.4 ENSMUST00000192101.5 uc292srh.1 uc292srh.2 uc292srh.1 uc292srh.2 
ENSMUST00000192105.2 Gm35048 ENSMUST00000192105.2 Gm35048 (from geneSymbol) ENSMUST00000192105.1 uc287khw.1 uc287khw.2 uc287khw.1 uc287khw.2 
ENSMUST00000192111.2 Gm37569 ENSMUST00000192111.2 Gm37569 (from geneSymbol) AK153869 ENSMUST00000192111.1 uc287gmd.1 uc287gmd.2 uc287gmd.1 uc287gmd.2 
ENSMUST00000192112.2 Gm38105 ENSMUST00000192112.2 Gm38105 (from geneSymbol) ENSMUST00000192112.1 uc289tfo.1 uc289tfo.2 uc289tfo.1 uc289tfo.2 
ENSMUST00000192113.2 3110062G12Rik ENSMUST00000192113.2 3110062G12Rik (from geneSymbol) ENSMUST00000192113.1 LF193032 uc287oey.1 uc287oey.2 uc287oey.1 uc287oey.2 
ENSMUST00000192114.2 Gm36962 ENSMUST00000192114.2 Gm36962 (from geneSymbol) ENSMUST00000192114.1 uc287qfm.1 uc287qfm.2 uc287qfm.1 uc287qfm.2 
ENSMUST00000192120.2 Gm37157 ENSMUST00000192120.2 Gm37157 (from geneSymbol) ENSMUST00000192120.1 uc292spx.1 uc292spx.2 uc292spx.1 uc292spx.2 
ENSMUST00000192122.2 Gm37903 ENSMUST00000192122.2 Gm37903 (from geneSymbol) ENSMUST00000192122.1 uc287mdp.1 uc287mdp.2 uc287mdp.1 uc287mdp.2 
ENSMUST00000192127.2 Gm38072 ENSMUST00000192127.2 Gm38072 (from geneSymbol) ENSMUST00000192127.1 uc292skp.1 uc292skp.2 uc292skp.1 uc292skp.2 
ENSMUST00000192131.2 Gm37189 ENSMUST00000192131.2 Gm37189 (from geneSymbol) ENSMUST00000192131.1 uc287uvv.1 uc287uvv.2 uc287uvv.1 uc287uvv.2 
ENSMUST00000192133.2 Gm37019 ENSMUST00000192133.2 Gm37019 (from geneSymbol) AK042921 ENSMUST00000192133.1 uc288itz.1 uc288itz.2 uc288itz.1 uc288itz.2 
ENSMUST00000192134.2 Gm37139 ENSMUST00000192134.2 Gm37139 (from geneSymbol) ENSMUST00000192134.1 uc289trp.1 uc289trp.2 uc289trp.1 uc289trp.2 
ENSMUST00000192137.2 3222401L13Rik ENSMUST00000192137.2 3222401L13Rik (from geneSymbol) AK045900 ENSMUST00000192137.1 uc008eqk.1 uc008eqk.2 uc008eqk.3 uc008eqk.1 uc008eqk.2 uc008eqk.3 
ENSMUST00000192140.2 Gm37124 ENSMUST00000192140.2 Gm37124 (from geneSymbol) ENSMUST00000192140.1 uc287mdx.1 uc287mdx.2 uc287mdx.1 uc287mdx.2 
ENSMUST00000192141.2 Gm37056 ENSMUST00000192141.2 Gm37056 (from geneSymbol) AK043198 ENSMUST00000192141.1 uc290fyc.1 uc290fyc.2 uc290fyc.1 uc290fyc.2 
ENSMUST00000192143.2 Gm38201 ENSMUST00000192143.2 Gm38201 (from geneSymbol) ENSMUST00000192143.1 uc290hex.1 uc290hex.2 uc290hex.1 uc290hex.2 
ENSMUST00000192147.2 Gm37691 ENSMUST00000192147.2 Gm37691 (from geneSymbol) AK031888 ENSMUST00000192147.1 uc287pdj.1 uc287pdj.2 uc287pdj.1 uc287pdj.2 
ENSMUST00000192149.2 Gm37854 ENSMUST00000192149.2 Gm37854 (from geneSymbol) AK144912 ENSMUST00000192149.1 uc290fbc.1 uc290fbc.2 uc290fbc.1 uc290fbc.2 
ENSMUST00000192151.6 Spata45 ENSMUST00000192151.6 spermatogenesis associated 45, transcript variant 1 (from RefSeq NM_001379428.1) ENSMUST00000192151.1 ENSMUST00000192151.2 ENSMUST00000192151.3 ENSMUST00000192151.4 ENSMUST00000192151.5 NM_001379428 Q9CVW4 SPT45_MOUSE uc287oyg.1 uc287oyg.2 Belongs to the SPATA45 family. Sequence=BAB24485.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc287oyg.1 uc287oyg.2 
ENSMUST00000192153.2 Gm37916 ENSMUST00000192153.2 Gm37916 (from geneSymbol) ENSMUST00000192153.1 uc287oei.1 uc287oei.2 uc287oei.1 uc287oei.2 
ENSMUST00000192154.2 Gm37537 ENSMUST00000192154.2 Gm37537 (from geneSymbol) AK043172 ENSMUST00000192154.1 uc290efi.1 uc290efi.2 uc290efi.1 uc290efi.2 
ENSMUST00000192162.2 Gm37622 ENSMUST00000192162.2 Gm37622 (from geneSymbol) ENSMUST00000192162.1 uc287mta.1 uc287mta.2 uc287mta.1 uc287mta.2 
ENSMUST00000192163.2 Gm37847 ENSMUST00000192163.2 Gm37847 (from geneSymbol) AK146199 ENSMUST00000192163.1 uc288vkb.1 uc288vkb.2 uc288vkb.1 uc288vkb.2 
ENSMUST00000192167.2 Gm37274 ENSMUST00000192167.2 Gm37274 (from geneSymbol) ENSMUST00000192167.1 uc290bvy.1 uc290bvy.2 uc290bvy.1 uc290bvy.2 
ENSMUST00000192168.2 Pcdha5 ENSMUST00000192168.2 protocadherin alpha 5 (from RefSeq NM_009959.2) ENSMUST00000192168.1 NM_009959 Pcdha5 Q91Y15 Q91Y15_MOUSE uc008eoz.1 uc008eoz.2 uc008eoz.3 uc008eoz.4 uc008eoz.5 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eoz.1 uc008eoz.2 uc008eoz.3 uc008eoz.4 uc008eoz.5 
ENSMUST00000192170.2 Gm37941 ENSMUST00000192170.2 Gm37941 (from geneSymbol) ENSMUST00000192170.1 uc292jjh.1 uc292jjh.2 uc292jjh.1 uc292jjh.2 
ENSMUST00000192176.2 Gm37376 ENSMUST00000192176.2 Gm37376 (from geneSymbol) ENSMUST00000192176.1 uc289qie.1 uc289qie.2 uc289qie.1 uc289qie.2 
ENSMUST00000192178.2 Gm37753 ENSMUST00000192178.2 Gm37753 (from geneSymbol) ENSMUST00000192178.1 uc289ote.1 uc289ote.2 uc289ote.1 uc289ote.2 
ENSMUST00000192182.2 Gm37957 ENSMUST00000192182.2 Gm37957 (from geneSymbol) ENSMUST00000192182.1 uc287iyg.1 uc287iyg.2 uc287iyg.1 uc287iyg.2 
ENSMUST00000192184.2 Gm37669 ENSMUST00000192184.2 Gm37669 (from geneSymbol) ENSMUST00000192184.1 LF192924 uc287mqe.1 uc287mqe.2 uc287mqe.1 uc287mqe.2 
ENSMUST00000192186.2 Gm37295 ENSMUST00000192186.2 Gm37295 (from geneSymbol) ENSMUST00000192186.1 uc290fah.1 uc290fah.2 uc290fah.1 uc290fah.2 
ENSMUST00000192188.3 Ighg2b ENSMUST00000192188.3 Ighg2b (from geneSymbol) A0A0A6YVP0 A0A0A6YVP0_MOUSE AK135975 ENSMUST00000192188.1 ENSMUST00000192188.2 Ighg2b uc007pgn.1 uc007pgn.2 uc007pgn.3 membrane integral component of membrane uc007pgn.1 uc007pgn.2 uc007pgn.3 
ENSMUST00000192190.2 Gm37644 ENSMUST00000192190.2 Gm37644 (from geneSymbol) AK035045 ENSMUST00000192190.1 uc287nhe.1 uc287nhe.2 uc287nhe.1 uc287nhe.2 
ENSMUST00000192195.6 Slamf7 ENSMUST00000192195.6 SLAM family member 7, transcript variant 1 (from RefSeq NM_144539.6) A0A0R4J2D8 A0A0R4J2D8_MOUSE ENSMUST00000192195.1 ENSMUST00000192195.2 ENSMUST00000192195.3 ENSMUST00000192195.4 ENSMUST00000192195.5 NM_144539 Slamf7 uc007dox.1 uc007dox.2 uc007dox.3 membrane integral component of membrane uc007dox.1 uc007dox.2 uc007dox.3 
ENSMUST00000192206.2 Gm37804 ENSMUST00000192206.2 Gm37804 (from geneSymbol) ENSMUST00000192206.1 uc288iai.1 uc288iai.2 uc288iai.1 uc288iai.2 
ENSMUST00000192207.2 Gm38226 ENSMUST00000192207.2 Gm38226 (from geneSymbol) AK206573 ENSMUST00000192207.1 uc292jxk.1 uc292jxk.2 uc292jxk.1 uc292jxk.2 
ENSMUST00000192212.2 Gm9867 ENSMUST00000192212.2 Gm9867 (from geneSymbol) AK030056 ENSMUST00000192212.1 uc290rft.1 uc290rft.2 uc290rft.1 uc290rft.2 
ENSMUST00000192213.2 Gm38177 ENSMUST00000192213.2 Gm38177 (from geneSymbol) AK043133 ENSMUST00000192213.1 uc287liz.1 uc287liz.2 uc287liz.1 uc287liz.2 
ENSMUST00000192216.2 Gm37880 ENSMUST00000192216.2 Gm37880 (from geneSymbol) AK047402 ENSMUST00000192216.1 uc287gxy.1 uc287gxy.2 uc287gxy.1 uc287gxy.2 
ENSMUST00000192217.2 Gm36966 ENSMUST00000192217.2 Gm36966 (from geneSymbol) ENSMUST00000192217.1 uc288pax.1 uc288pax.2 uc288pax.1 uc288pax.2 
ENSMUST00000192219.2 Gm37121 ENSMUST00000192219.2 Gm37121 (from geneSymbol) AK046710 ENSMUST00000192219.1 uc287iqu.1 uc287iqu.2 uc287iqu.1 uc287iqu.2 
ENSMUST00000192224.2 Gm37024 ENSMUST00000192224.2 Gm37024 (from geneSymbol) ENSMUST00000192224.1 uc290ehe.1 uc290ehe.2 uc290ehe.1 uc290ehe.2 
ENSMUST00000192227.6 Rgs7 ENSMUST00000192227.6 regulator of G protein signaling 7, transcript variant 1 (from RefSeq NM_011880.3) E9QLB9 ENSMUST00000192227.1 ENSMUST00000192227.2 ENSMUST00000192227.3 ENSMUST00000192227.4 ENSMUST00000192227.5 NM_011880 O54829 RGS7_MOUSE uc007dtk.1 uc007dtk.2 uc007dtk.3 uc007dtk.4 GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades (PubMed:25792749). The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP- bound form (By similarity). May play a role in synaptic vesicle exocytosis (By similarity). Glycine-dependent regulation of the RGS7- GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (PubMed:31311860, PubMed:30546127). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (By similarity). Interacts with GNB5, forming the RGS7-GNB5 complex (By similarity). Interacts with GPR158; promotes the GTPase activator activity of the RGS7-GNB5 complex in absence of glycine, in contrast GTPase activator activity of the RGS7-GNB5 complex is inhibited in presence of glycine (PubMed:22689652, PubMed:25792749, PubMed:31311860). Interacts with GPR179 (PubMed:22689652). Interacts with PKD1; this prevents rapid proteasomal degradation (By similarity). Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (PubMed:15632198, PubMed:15897264). Interacts (phosphorylated form) with 14-3-3 protein YWHAQ (PubMed:10862767). Interacts with SNAPIN (By similarity). Interacts with GNAI1 (By similarity). Interacts with GNAO1, GNAI3 and GNAZ (By similarity). Cytoplasm, cytosol Cytoplasm Cell membrane mbrane ; Peripheral membrane protein ; Cytoplasmic side Note=Interaction with PKD1 promotes location at the cell membrane. Interaction with RGS7BP promotes location at the cell membrane. Detected in brain (at protein level). Palmitoylated. Ubiquitinated, leading to rapid proteasomal degradation. Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity. G-protein alpha-subunit binding GTPase activator activity protein binding nucleus nuclear envelope cytoplasm cytosol plasma membrane G-protein coupled receptor signaling pathway regulation of G-protein coupled receptor protein signaling pathway negative regulation of signal transduction membrane G-protein beta-subunit binding macromolecular complex intracellular signal transduction positive regulation of GTPase activity dendrite terminus membrane raft postsynaptic membrane regulation of postsynaptic membrane potential presynapse glutamatergic synapse positive regulation of potassium ion transmembrane transport uc007dtk.1 uc007dtk.2 uc007dtk.3 uc007dtk.4 
ENSMUST00000192232.2 Gm33320 ENSMUST00000192232.2 Gm33320 (from geneSymbol) ENSMUST00000192232.1 uc291jcb.1 uc291jcb.2 uc291jcb.1 uc291jcb.2 
ENSMUST00000192234.3 4930403P22Rik ENSMUST00000192234.3 4930403P22Rik (from geneSymbol) BC048582 ENSMUST00000192234.1 ENSMUST00000192234.2 uc287hgx.1 uc287hgx.2 uc287hgx.3 uc287hgx.1 uc287hgx.2 uc287hgx.3 
ENSMUST00000192238.2 Gm37927 ENSMUST00000192238.2 Gm37927 (from geneSymbol) ENSMUST00000192238.1 FJ386436 uc292smi.1 uc292smi.2 uc292smi.1 uc292smi.2 
ENSMUST00000192244.2 Gm37766 ENSMUST00000192244.2 Gm37766 (from geneSymbol) ENSMUST00000192244.1 uc289szt.1 uc289szt.2 uc289szt.1 uc289szt.2 
ENSMUST00000192251.2 Gm37105 ENSMUST00000192251.2 Gm37105 (from geneSymbol) AK134256 ENSMUST00000192251.1 uc292irb.1 uc292irb.2 uc292irb.1 uc292irb.2 
ENSMUST00000192253.2 9530018H14Rik ENSMUST00000192253.2 9530018H14Rik (from geneSymbol) AK020562 ENSMUST00000192253.1 uc057bxf.1 uc057bxf.2 uc057bxf.3 uc057bxf.1 uc057bxf.2 uc057bxf.3 
ENSMUST00000192254.2 Gm37268 ENSMUST00000192254.2 Gm37268 (from geneSymbol) ENSMUST00000192254.1 uc290eyq.1 uc290eyq.2 uc290eyq.1 uc290eyq.2 
ENSMUST00000192256.2 Gm37578 ENSMUST00000192256.2 Gm37578 (from geneSymbol) AK087054 ENSMUST00000192256.1 uc287mwx.1 uc287mwx.2 uc287mwx.1 uc287mwx.2 
ENSMUST00000192257.2 Gm36944 ENSMUST00000192257.2 Gm36944 (from geneSymbol) ENSMUST00000192257.1 uc287kzm.1 uc287kzm.2 uc287kzm.1 uc287kzm.2 
ENSMUST00000192258.2 Gm37932 ENSMUST00000192258.2 Gm37932 (from geneSymbol) AK087857 ENSMUST00000192258.1 uc287jqj.1 uc287jqj.2 uc287jqj.1 uc287jqj.2 
ENSMUST00000192259.2 Gm37459 ENSMUST00000192259.2 Gm37459 (from geneSymbol) AK050466 ENSMUST00000192259.1 uc290ekz.1 uc290ekz.2 uc290ekz.1 uc290ekz.2 
ENSMUST00000192264.2 Ighv5-9-1 ENSMUST00000192264.2 Ighv5-9-1 (from geneSymbol) A0A0A6YVS4 A0A0A6YVS4_MOUSE ENSMUST00000192264.1 Ighv5-9-1 LC037230 uc288juc.1 uc288juc.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288juc.1 uc288juc.2 
ENSMUST00000192265.2 Gm37415 ENSMUST00000192265.2 Gm37415 (from geneSymbol) ENSMUST00000192265.1 uc290zve.1 uc290zve.2 uc290zve.1 uc290zve.2 
ENSMUST00000192266.2 Gm37154 ENSMUST00000192266.2 Gm37154 (from geneSymbol) AK053662 ENSMUST00000192266.1 uc287nuf.1 uc287nuf.2 uc287nuf.1 uc287nuf.2 
ENSMUST00000192267.2 9330121J05Rik ENSMUST00000192267.2 9330121J05Rik (from geneSymbol) AK033940 ENSMUST00000192267.1 uc290fox.1 uc290fox.2 uc290fox.1 uc290fox.2 
ENSMUST00000192272.2 Gm37524 ENSMUST00000192272.2 Gm37524 (from geneSymbol) ENSMUST00000192272.1 uc007dlh.1 uc007dlh.2 uc007dlh.3 uc007dlh.1 uc007dlh.2 uc007dlh.3 
ENSMUST00000192275.2 Gm37631 ENSMUST00000192275.2 Gm37631 (from geneSymbol) ENSMUST00000192275.1 uc287uke.1 uc287uke.2 uc287uke.1 uc287uke.2 
ENSMUST00000192276.2 Gm38254 ENSMUST00000192276.2 Gm38254 (from geneSymbol) AK142269 ENSMUST00000192276.1 uc292iye.1 uc292iye.2 uc292iye.1 uc292iye.2 
ENSMUST00000192285.2 Gm38155 ENSMUST00000192285.2 Gm38155 (from geneSymbol) BC072557 ENSMUST00000192285.1 uc287ovg.1 uc287ovg.2 uc287ovg.1 uc287ovg.2 
ENSMUST00000192292.2 Gm37703 ENSMUST00000192292.2 Gm37703 (from geneSymbol) AK137650 ENSMUST00000192292.1 uc289tpk.1 uc289tpk.2 uc289tpk.1 uc289tpk.2 
ENSMUST00000192296.2 Gm38271 ENSMUST00000192296.2 Gm38271 (from geneSymbol) AB350833 ENSMUST00000192296.1 uc290inl.1 uc290inl.2 uc290inl.1 uc290inl.2 
ENSMUST00000192297.3 Gm31406 ENSMUST00000192297.3 Gm31406 (from geneSymbol) ENSMUST00000192297.1 ENSMUST00000192297.2 uc287pby.1 uc287pby.2 uc287pby.3 uc287pby.1 uc287pby.2 uc287pby.3 
ENSMUST00000192298.2 Ighv8-4 ENSMUST00000192298.2 Ighv8-4 (from geneSymbol) A0A0A6YW26 A0A0A6YW26_MOUSE ENSMUST00000192298.1 Ighv8-4 uc288jzv.1 uc288jzv.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jzv.1 uc288jzv.2 
ENSMUST00000192299.2 E330040D14Rik ENSMUST00000192299.2 E330040D14Rik (from geneSymbol) ENSMUST00000192299.1 uc287gkp.1 uc287gkp.2 uc287gkp.1 uc287gkp.2 
ENSMUST00000192301.2 Gm38281 ENSMUST00000192301.2 Gm38281 (from geneSymbol) ENSMUST00000192301.1 uc287uxe.1 uc287uxe.2 uc287uxe.1 uc287uxe.2 
ENSMUST00000192303.2 Gm37675 ENSMUST00000192303.2 Gm37675 (from geneSymbol) ENSMUST00000192303.1 uc290fea.1 uc290fea.2 uc290fea.1 uc290fea.2 
ENSMUST00000192309.2 Gm37939 ENSMUST00000192309.2 Gm37939 (from geneSymbol) ENSMUST00000192309.1 uc290zss.1 uc290zss.2 uc290zss.1 uc290zss.2 
ENSMUST00000192316.2 4930594C11Rik ENSMUST00000192316.2 RIKEN cDNA 4930594C11 gene (from RefSeq NR_024017.2) ENSMUST00000192316.1 NR_024017 uc011wjs.1 uc011wjs.2 uc011wjs.1 uc011wjs.2 
ENSMUST00000192317.3 Gm37096 ENSMUST00000192317.3 Gm37096 (from geneSymbol) ENSMUST00000192317.1 ENSMUST00000192317.2 uc287mkn.1 uc287mkn.2 uc287mkn.1 uc287mkn.2 
ENSMUST00000192320.2 Gm38197 ENSMUST00000192320.2 Gm38197 (from geneSymbol) ENSMUST00000192320.1 uc290egz.1 uc290egz.2 uc290egz.1 uc290egz.2 
ENSMUST00000192321.2 Gm38215 ENSMUST00000192321.2 Gm38215 (from geneSymbol) ENSMUST00000192321.1 LF197693 uc292itd.1 uc292itd.2 uc292itd.1 uc292itd.2 
ENSMUST00000192325.2 Gm37334 ENSMUST00000192325.2 Gm37334 (from geneSymbol) ENSMUST00000192325.1 LF193108 uc287peh.1 uc287peh.2 uc287peh.1 uc287peh.2 
ENSMUST00000192326.2 Gm37485 ENSMUST00000192326.2 Gm37485 (from geneSymbol) ENSMUST00000192326.1 LF270978 uc287kbh.1 uc287kbh.2 uc287kbh.1 uc287kbh.2 
ENSMUST00000192330.2 Gm37842 ENSMUST00000192330.2 Gm37842 (from geneSymbol) ENSMUST00000192330.1 LF197616 uc292hlp.1 uc292hlp.2 uc292hlp.1 uc292hlp.2 
ENSMUST00000192336.2 Gm37363 ENSMUST00000192336.2 Gm37363 (from geneSymbol) ENSMUST00000192336.1 uc287gdg.1 uc287gdg.2 uc287gdg.1 uc287gdg.2 
ENSMUST00000192337.2 Gm37708 ENSMUST00000192337.2 Gm37708 (from geneSymbol) ENSMUST00000192337.1 uc288pav.1 uc288pav.2 uc288pav.1 uc288pav.2 
ENSMUST00000192338.2 Gm38024 ENSMUST00000192338.2 Gm38024 (from geneSymbol) AK045657 ENSMUST00000192338.1 uc287gij.1 uc287gij.2 uc287gij.1 uc287gij.2 
ENSMUST00000192339.2 Gm26524 ENSMUST00000192339.2 Gm26524 (from geneSymbol) AK005585 ENSMUST00000192339.1 uc287gwd.1 uc287gwd.2 uc287gwd.1 uc287gwd.2 
ENSMUST00000192340.2 Gm36981 ENSMUST00000192340.2 Gm36981 (from geneSymbol) ENSMUST00000192340.1 uc290gfp.1 uc290gfp.2 uc290gfp.1 uc290gfp.2 
ENSMUST00000192346.2 Gm38067 ENSMUST00000192346.2 Gm38067 (from geneSymbol) ENSMUST00000192346.1 uc287lqa.1 uc287lqa.2 uc287lqa.1 uc287lqa.2 
ENSMUST00000192347.2 5930409G06Rik ENSMUST00000192347.2 5930409G06Rik (from geneSymbol) AK080646 ENSMUST00000192347.1 uc290ezk.1 uc290ezk.2 uc290ezk.1 uc290ezk.2 
ENSMUST00000192348.2 9630010A21Rik ENSMUST00000192348.2 9630010A21Rik (from geneSymbol) AK035844 ENSMUST00000192348.1 uc287pei.1 uc287pei.2 uc287pei.1 uc287pei.2 
ENSMUST00000192349.6 Gm37870 ENSMUST00000192349.6 Gm37870 (from geneSymbol) ENSMUST00000192349.1 ENSMUST00000192349.2 ENSMUST00000192349.3 ENSMUST00000192349.4 ENSMUST00000192349.5 uc292shi.1 uc292shi.2 uc292shi.1 uc292shi.2 
ENSMUST00000192350.2 Gm38190 ENSMUST00000192350.2 Gm38190 (from geneSymbol) AK164503 ENSMUST00000192350.1 uc287nju.1 uc287nju.2 uc287nju.1 uc287nju.2 
ENSMUST00000192353.2 Gm37665 ENSMUST00000192353.2 Gm37665 (from geneSymbol) AK199184 ENSMUST00000192353.1 uc292jph.1 uc292jph.2 uc292jph.1 uc292jph.2 
ENSMUST00000192354.2 Gm38242 ENSMUST00000192354.2 Gm38242 (from geneSymbol) ENSMUST00000192354.1 uc290tem.1 uc290tem.2 uc290tem.1 uc290tem.2 
ENSMUST00000192356.2 Gm37427 ENSMUST00000192356.2 Gm37427 (from geneSymbol) ENSMUST00000192356.1 uc288pyp.1 uc288pyp.2 uc288pyp.1 uc288pyp.2 
ENSMUST00000192358.3 Or6p1 ENSMUST00000192358.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q5P8) E9Q5P8 E9Q5P8_MOUSE ENSMUST00000192358.1 ENSMUST00000192358.2 Olfr414 Or6p1 uc287ocp.1 uc287ocp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ocp.1 uc287ocp.2 
ENSMUST00000192361.2 Gm10848 ENSMUST00000192361.2 Gm10848 (from geneSymbol) AK138658 ENSMUST00000192361.1 uc008iko.1 uc008iko.2 uc008iko.1 uc008iko.2 
ENSMUST00000192362.2 Gm37872 ENSMUST00000192362.2 Gm37872 (from geneSymbol) ENSMUST00000192362.1 uc288mvj.1 uc288mvj.2 uc288mvj.1 uc288mvj.2 
ENSMUST00000192363.2 Gm37566 ENSMUST00000192363.2 Gm37566 (from geneSymbol) AK031031 ENSMUST00000192363.1 uc287kwl.1 uc287kwl.2 uc287kwl.1 uc287kwl.2 
ENSMUST00000192366.2 Trbj1-3 ENSMUST00000192366.2 Trbj1-3 (from geneSymbol) A0A0A6YXA0 A0A0A6YXA0_MOUSE AF005627 ENSMUST00000192366.1 Trbj1-3 uc291dvl.1 uc291dvl.2 uc291dvl.1 uc291dvl.2 
ENSMUST00000192367.2 Gm37331 ENSMUST00000192367.2 Gm37331 (from geneSymbol) AK140007 ENSMUST00000192367.1 uc287gxu.1 uc287gxu.2 uc287gxu.1 uc287gxu.2 
ENSMUST00000192369.6 Styxl2 ENSMUST00000192369.6 May be required for myofiber maturation. (from UniProt Q148W8) AK142263 Dusp27 ENSMUST00000192369.1 ENSMUST00000192369.2 ENSMUST00000192369.3 ENSMUST00000192369.4 ENSMUST00000192369.5 Q148W8 Q3UQN8 Q6PCZ9 Q8BX87 STYL2_MOUSE uc007dki.1 uc007dki.2 uc007dki.3 uc007dki.4 May be required for myofiber maturation. Cytoplasm, myofibril, sarcomere Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. Ser-225 is present instead of the conserved Cys which is expected to be an active site residue suggesting that this protein has lost its phosphatase activity. cellular_component cytoplasm protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation phosphatase activity sarcomere uc007dki.1 uc007dki.2 uc007dki.3 uc007dki.4 
ENSMUST00000192371.2 Gm37581 ENSMUST00000192371.2 Gm37581 (from geneSymbol) ENSMUST00000192371.1 LF197678 uc292ipx.1 uc292ipx.2 uc292ipx.1 uc292ipx.2 
ENSMUST00000192375.3 2010103J01Rik ENSMUST00000192375.3 2010103J01Rik (from geneSymbol) AK008306 ENSMUST00000192375.1 ENSMUST00000192375.2 uc287otf.1 uc287otf.2 uc287otf.3 uc287otf.1 uc287otf.2 uc287otf.3 
ENSMUST00000192379.2 Gm38346 ENSMUST00000192379.2 Gm38346 (from geneSymbol) ENSMUST00000192379.1 uc292fnw.1 uc292fnw.2 uc292fnw.1 uc292fnw.2 
ENSMUST00000192380.2 Gm38054 ENSMUST00000192380.2 Gm38054 (from geneSymbol) ENSMUST00000192380.1 uc292sng.1 uc292sng.2 uc292sng.1 uc292sng.2 
ENSMUST00000192381.2 Gm38180 ENSMUST00000192381.2 Gm38180 (from geneSymbol) ENSMUST00000192381.1 uc290wmf.1 uc290wmf.2 uc290wmf.1 uc290wmf.2 
ENSMUST00000192385.2 A030012G06Rik ENSMUST00000192385.2 A030012G06Rik (from geneSymbol) AK037236 ENSMUST00000192385.1 uc292jwk.1 uc292jwk.2 uc292jwk.1 uc292jwk.2 
ENSMUST00000192386.2 Gm37357 ENSMUST00000192386.2 Gm37357 (from geneSymbol) ENSMUST00000192386.1 uc287ned.1 uc287ned.2 uc287ned.1 uc287ned.2 
ENSMUST00000192388.2 Gm36958 ENSMUST00000192388.2 Gm36958 (from geneSymbol) AK135811 ENSMUST00000192388.1 uc292kdq.1 uc292kdq.2 uc292kdq.1 uc292kdq.2 
ENSMUST00000192389.2 Gm37204 ENSMUST00000192389.2 Gm37204 (from geneSymbol) ENSMUST00000192389.1 uc292kak.1 uc292kak.2 uc292kak.1 uc292kak.2 
ENSMUST00000192390.2 Gm38000 ENSMUST00000192390.2 Gm38000 (from geneSymbol) ENSMUST00000192390.1 uc290fdz.1 uc290fdz.2 uc290fdz.1 uc290fdz.2 
ENSMUST00000192391.2 Gm20089 ENSMUST00000192391.2 Gm20089 (from geneSymbol) AK148003 ENSMUST00000192391.1 uc290fee.1 uc290fee.2 uc290fee.1 uc290fee.2 
ENSMUST00000192396.2 Gm37738 ENSMUST00000192396.2 Gm37738 (from geneSymbol) ENSMUST00000192396.1 uc287jvi.1 uc287jvi.2 uc287jvi.1 uc287jvi.2 
ENSMUST00000192397.2 Gm38147 ENSMUST00000192397.2 Gm38147 (from geneSymbol) ENSMUST00000192397.1 uc289tro.1 uc289tro.2 uc289tro.1 uc289tro.2 
ENSMUST00000192399.2 Gm37053 ENSMUST00000192399.2 Gm37053 (from geneSymbol) ENSMUST00000192399.1 uc287kxi.1 uc287kxi.2 uc287kxi.1 uc287kxi.2 
ENSMUST00000192402.2 Gm37960 ENSMUST00000192402.2 Gm37960 (from geneSymbol) ENSMUST00000192402.1 LF204561 uc287ofr.1 uc287ofr.2 uc287ofr.1 uc287ofr.2 
ENSMUST00000192404.2 1700074A21Rik ENSMUST00000192404.2 1700074A21Rik (from geneSymbol) AK006946 ENSMUST00000192404.1 uc287hke.1 uc287hke.2 uc287hke.1 uc287hke.2 
ENSMUST00000192406.2 Gm37527 ENSMUST00000192406.2 Gm37527 (from geneSymbol) ENSMUST00000192406.1 uc291dwl.1 uc291dwl.2 uc291dwl.1 uc291dwl.2 
ENSMUST00000192407.3 A230020J21Rik ENSMUST00000192407.3 RIKEN cDNA A230020J21 gene (from RefSeq NR_027298.1) ENSMUST00000192407.1 ENSMUST00000192407.2 NR_027298 uc011wyo.1 uc011wyo.2 uc011wyo.3 uc011wyo.1 uc011wyo.2 uc011wyo.3 
ENSMUST00000192408.2 Gm37580 ENSMUST00000192408.2 Gm37580 (from geneSymbol) ENSMUST00000192408.1 LF192589 uc287gwm.1 uc287gwm.2 uc287gwm.1 uc287gwm.2 
ENSMUST00000192409.2 Pcdhb22 ENSMUST00000192409.2 protocadherin beta 22 (from RefSeq NM_053147.4) ENSMUST00000192409.1 NM_053147 Pcdhb22 Q91XZ8 Q91XZ8_MOUSE uc012bby.1 uc012bby.2 uc012bby.3 uc012bby.4 calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane photoreceptor connecting cilium uc012bby.1 uc012bby.2 uc012bby.3 uc012bby.4 
ENSMUST00000192413.3 Gm56350 ENSMUST00000192413.3 Gm56350 (from geneSymbol) ENSMUST00000192413.1 ENSMUST00000192413.2 LF193577 uc290ajo.1 uc290ajo.2 uc290ajo.3 uc290ajo.1 uc290ajo.2 uc290ajo.3 
ENSMUST00000192416.2 Gm37811 ENSMUST00000192416.2 Gm37811 (from geneSymbol) ENSMUST00000192416.1 LF202386 uc289tdp.1 uc289tdp.2 uc289tdp.1 uc289tdp.2 
ENSMUST00000192417.2 Gm37538 ENSMUST00000192417.2 Gm37538 (from geneSymbol) ENSMUST00000192417.1 uc292som.1 uc292som.2 uc292som.1 uc292som.2 
ENSMUST00000192418.2 Gm38091 ENSMUST00000192418.2 Gm38091 (from geneSymbol) ENSMUST00000192418.1 uc292jnh.1 uc292jnh.2 uc292jnh.1 uc292jnh.2 
ENSMUST00000192421.2 Gm38006 ENSMUST00000192421.2 Gm38006 (from geneSymbol) ENSMUST00000192421.1 uc290kgh.1 uc290kgh.2 uc290kgh.1 uc290kgh.2 
ENSMUST00000192431.2 Gm37464 ENSMUST00000192431.2 Gm37464 (from geneSymbol) AK082232 ENSMUST00000192431.1 uc290fyp.1 uc290fyp.2 uc290fyp.1 uc290fyp.2 
ENSMUST00000192432.2 Gm37730 ENSMUST00000192432.2 Gm37730 (from geneSymbol) ENSMUST00000192432.1 uc289szy.1 uc289szy.2 uc289szy.1 uc289szy.2 
ENSMUST00000192440.2 Gm37751 ENSMUST00000192440.2 Gm37751 (from geneSymbol) ENSMUST00000192440.1 uc289ota.1 uc289ota.2 uc289ota.1 uc289ota.2 
ENSMUST00000192441.2 Gm37018 ENSMUST00000192441.2 Gm37018 (from geneSymbol) ENSMUST00000192441.1 uc287oos.1 uc287oos.2 uc287oos.1 uc287oos.2 
ENSMUST00000192443.2 Gm37543 ENSMUST00000192443.2 Gm37543 (from geneSymbol) AK082670 ENSMUST00000192443.1 uc287gxt.1 uc287gxt.2 uc287gxt.1 uc287gxt.2 
ENSMUST00000192446.2 Gm38276 ENSMUST00000192446.2 Gm38276 (from geneSymbol) AK041452 ENSMUST00000192446.1 uc291dtu.1 uc291dtu.2 uc291dtu.1 uc291dtu.2 
ENSMUST00000192448.2 Gm37895 ENSMUST00000192448.2 Gm37895 (from geneSymbol) ENSMUST00000192448.1 uc287gyj.1 uc287gyj.2 uc287gyj.1 uc287gyj.2 
ENSMUST00000192452.2 Gm37390 ENSMUST00000192452.2 Gm37390 (from geneSymbol) AK038036 ENSMUST00000192452.1 uc287okl.1 uc287okl.2 uc287okl.1 uc287okl.2 
ENSMUST00000192459.2 Gm37964 ENSMUST00000192459.2 Gm37964 (from geneSymbol) ENSMUST00000192459.1 uc289wou.1 uc289wou.2 uc289wou.1 uc289wou.2 
ENSMUST00000192464.2 Gm37541 ENSMUST00000192464.2 Gm37541 (from geneSymbol) ENSMUST00000192464.1 uc287kbl.1 uc287kbl.2 uc287kbl.1 uc287kbl.2 
ENSMUST00000192473.2 Gm37844 ENSMUST00000192473.2 Gm37844 (from geneSymbol) ENSMUST00000192473.1 uc291yly.1 uc291yly.2 uc291yly.1 uc291yly.2 
ENSMUST00000192480.2 Gm19863 ENSMUST00000192480.2 Gm19863 (from geneSymbol) ENSMUST00000192480.1 uc287hlf.1 uc287hlf.2 uc287hlf.1 uc287hlf.2 
ENSMUST00000192482.2 Gm17244 ENSMUST00000192482.2 predicted gene, 17244 (from RefSeq NR_171029.1) ENSMUST00000192482.1 NR_171029 uc290ppn.1 uc290ppn.2 uc290ppn.1 uc290ppn.2 
ENSMUST00000192484.2 Gm37210 ENSMUST00000192484.2 Gm37210 (from geneSymbol) ENSMUST00000192484.1 uc287jrm.1 uc287jrm.2 uc287jrm.1 uc287jrm.2 
ENSMUST00000192487.2 Gm36949 ENSMUST00000192487.2 Gm36949 (from geneSymbol) AK132615 ENSMUST00000192487.1 uc287guu.1 uc287guu.2 uc287guu.1 uc287guu.2 
ENSMUST00000192490.2 Gm38061 ENSMUST00000192490.2 Gm38061 (from geneSymbol) ENSMUST00000192490.1 uc287xgg.1 uc287xgg.2 uc287xgg.1 uc287xgg.2 
ENSMUST00000192493.2 Gm35670 ENSMUST00000192493.2 Gm35670 (from geneSymbol) ENSMUST00000192493.1 uc292spk.1 uc292spk.2 uc292spk.1 uc292spk.2 
ENSMUST00000192496.2 Gm37828 ENSMUST00000192496.2 Gm37828 (from geneSymbol) ENSMUST00000192496.1 uc289pdu.1 uc289pdu.2 uc289pdu.1 uc289pdu.2 
ENSMUST00000192498.2 Gm37065 ENSMUST00000192498.2 Gm37065 (from geneSymbol) AK037426 ENSMUST00000192498.1 uc287nvy.1 uc287nvy.2 uc287nvy.1 uc287nvy.2 
ENSMUST00000192499.3 Ighv7-4 ENSMUST00000192499.3 Ighv7-4 (from geneSymbol) A0A0A6YXL5 A0A0A6YXL5_MOUSE ENSMUST00000192499.1 ENSMUST00000192499.2 Ighv7-4 X66656 uc288jwb.1 uc288jwb.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jwb.1 uc288jwb.2 
ENSMUST00000192500.2 Gm34240 ENSMUST00000192500.2 predicted gene, 34240 (from RefSeq NR_153189.1) ENSMUST00000192500.1 NR_153189 uc290fpp.1 uc290fpp.2 uc290fpp.1 uc290fpp.2 
ENSMUST00000192502.2 Gm37131 ENSMUST00000192502.2 Gm37131 (from geneSymbol) ENSMUST00000192502.1 uc290fsr.1 uc290fsr.2 uc290fsr.1 uc290fsr.2 
ENSMUST00000192503.2 Pcdha3 ENSMUST00000192503.2 protocadherin alpha 3 (from RefSeq NM_138662.2) ENSMUST00000192503.1 NM_138662 Pcdha3 Q91Y16 Q91Y16_MOUSE uc008eow.1 uc008eow.2 uc008eow.3 uc008eow.4 uc008eow.5 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eow.1 uc008eow.2 uc008eow.3 uc008eow.4 uc008eow.5 
ENSMUST00000192504.2 Gm36927 ENSMUST00000192504.2 Gm36927 (from geneSymbol) AK134083 ENSMUST00000192504.1 uc292jhh.1 uc292jhh.2 uc292jhh.1 uc292jhh.2 
ENSMUST00000192511.2 Pcdhga7 ENSMUST00000192511.2 protocadherin gamma subfamily A, 7 (from RefSeq NM_033590.3) ENSMUST00000192511.1 NM_033590 Pcdhga7 Q6DD96 Q6DD96_MOUSE uc008eqt.1 uc008eqt.2 uc008eqt.3 uc008eqt.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eqt.1 uc008eqt.2 uc008eqt.3 uc008eqt.4 
ENSMUST00000192512.6 Pcdha4 ENSMUST00000192512.6 protocadherin alpha 4 (from RefSeq NM_007766.2) Cnr1 ENSMUST00000192512.1 ENSMUST00000192512.2 ENSMUST00000192512.3 ENSMUST00000192512.4 ENSMUST00000192512.5 NM_007766 O88689 PCDA4_MOUSE Pcdha4 Q3UEX3 Q6PAM9 Q8K487 Q8K489 uc008eox.1 uc008eox.2 uc008eox.3 uc008eox.4 uc008eox.5 uc008eox.6 Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (Probable). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523). Forms homodimers in trans (molecules expressed by two different cells) (PubMed:27161523). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins (PubMed:27161523). Interacts with FYN (PubMed:9655502). O88689-1; Q99LI8: Hgs; NbExp=2; IntAct=EBI-15880299, EBI-2119135; Cell membrane ; Single-pass type I membrane protein te=Detected in dendrites and synapses. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O88689-1; Sequence=Displayed; Name=2; IsoId=O88689-2; Sequence=VSP_019413, VSP_019415; Name=3; IsoId=O88689-3; Sequence=VSP_019414; Detected in brain throughout embryonic development. Detected in adult brain, in particular in cerebellum and forebrain. Cadherin 1 to cadherin 4 domains mediate homophilic trans- interaction, the interaction with an identical protocadherin expressed by a neighboring cell (PubMed:27161523). This is an head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin (PubMed:27161523). The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane (PubMed:27161523). Each cadherin domain binds three calcium ions (PubMed:27161523). The protocadherins alpha are expressed from a single gene cluster similarly to immunoglobulin and T-cell receptors. The N- terminal region containing the 6 extracellular cadherin domains, unique to each protocadherin alpha, is encoded by one of the large exons found in tandem array within the gene cluster. The C-terminal region, identical to all protocadherins alpha, is encoded by 3 shared exons. calcium ion binding protein binding endoplasmic reticulum plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane identical protein binding synapse metal ion binding uc008eox.1 uc008eox.2 uc008eox.3 uc008eox.4 uc008eox.5 uc008eox.6 
ENSMUST00000192513.2 Gm37181 ENSMUST00000192513.2 Gm37181 (from geneSymbol) AK052267 ENSMUST00000192513.1 uc287ixa.1 uc287ixa.2 uc287ixa.1 uc287ixa.2 
ENSMUST00000192514.2 Gm38355 ENSMUST00000192514.2 Gm38355 (from geneSymbol) ENSMUST00000192514.1 uc288hxp.1 uc288hxp.2 uc288hxp.1 uc288hxp.2 
ENSMUST00000192515.2 Gm37093 ENSMUST00000192515.2 Gm37093 (from geneSymbol) ENSMUST00000192515.1 uc288wed.1 uc288wed.2 uc288wed.1 uc288wed.2 
ENSMUST00000192516.6 Gm37952 ENSMUST00000192516.6 Gm37952 (from geneSymbol) ENSMUST00000192516.1 ENSMUST00000192516.2 ENSMUST00000192516.3 ENSMUST00000192516.4 ENSMUST00000192516.5 uc292sos.1 uc292sos.2 uc292sos.1 uc292sos.2 
ENSMUST00000192517.2 Gm37022 ENSMUST00000192517.2 Gm37022 (from geneSymbol) AK157497 ENSMUST00000192517.1 uc287kbb.1 uc287kbb.2 uc287kbb.1 uc287kbb.2 
ENSMUST00000192521.2 Gm31571 ENSMUST00000192521.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WP44) A0A087WP44 A0A087WP44_MOUSE ENSMUST00000192521.1 Gm21760 Gm28827 Gm28897 Gm29110 Gm29564 Gm31571 uc292snp.1 uc292snp.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292snp.1 uc292snp.2 
ENSMUST00000192524.2 Gm37787 ENSMUST00000192524.2 Gm37787 (from geneSymbol) ENSMUST00000192524.1 uc287nvh.1 uc287nvh.2 uc287nvh.1 uc287nvh.2 
ENSMUST00000192526.2 Gm36935 ENSMUST00000192526.2 Gm36935 (from geneSymbol) ENSMUST00000192526.1 uc287utr.1 uc287utr.2 uc287utr.1 uc287utr.2 
ENSMUST00000192533.2 Gm37364 ENSMUST00000192533.2 Gm37364 (from geneSymbol) AK052149 ENSMUST00000192533.1 uc291xmh.1 uc291xmh.2 uc291xmh.1 uc291xmh.2 
ENSMUST00000192535.2 Pcdhgb5 ENSMUST00000192535.2 protocadherin gamma subfamily B, 5 (from RefSeq NM_033577.2) ENSMUST00000192535.1 NM_033577 Pcdhgb5 Q91XX5 Q91XX5_MOUSE uc008eqw.1 uc008eqw.2 uc008eqw.3 uc008eqw.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eqw.1 uc008eqw.2 uc008eqw.3 uc008eqw.4 
ENSMUST00000192536.2 Gm37945 ENSMUST00000192536.2 Gm37945 (from geneSymbol) ENSMUST00000192536.1 uc292kci.1 uc292kci.2 uc292kci.1 uc292kci.2 
ENSMUST00000192537.2 Gm37504 ENSMUST00000192537.2 Gm37504 (from geneSymbol) ENSMUST00000192537.1 uc288tvk.1 uc288tvk.2 uc288tvk.1 uc288tvk.2 
ENSMUST00000192538.2 Adrm1b ENSMUST00000192538.2 Cytoplasm Nucleus (from UniProt A0A0A6YVU8) A0A0A6YVU8 A0A0A6YVU8_MOUSE Adrm1b BC031517 ENSMUST00000192538.1 Gm9774 uc290heo.1 uc290heo.2 Cytoplasm Nucleus Belongs to the ADRM1 family. nucleus cytoplasm ubiquitin-dependent protein catabolic process proteasome regulatory particle, lid subcomplex positive regulation of endopeptidase activity ubiquitin binding endopeptidase activator activity proteasome binding uc290heo.1 uc290heo.2 
ENSMUST00000192540.2 Gm38141 ENSMUST00000192540.2 Gm38141 (from geneSymbol) ENSMUST00000192540.1 uc287vfb.1 uc287vfb.2 uc287vfb.1 uc287vfb.2 
ENSMUST00000192541.2 Gm38062 ENSMUST00000192541.2 Gm38062 (from geneSymbol) AK041387 ENSMUST00000192541.1 uc287jre.1 uc287jre.2 uc287jre.1 uc287jre.2 
ENSMUST00000192542.2 Gm37343 ENSMUST00000192542.2 Gm37343 (from geneSymbol) ENSMUST00000192542.1 uc289szk.1 uc289szk.2 uc289szk.1 uc289szk.2 
ENSMUST00000192543.2 5830415G21Rik ENSMUST00000192543.2 5830415G21Rik (from geneSymbol) AK017932 ENSMUST00000192543.1 uc290fbi.1 uc290fbi.2 uc290fbi.1 uc290fbi.2 
ENSMUST00000192545.6 Gm38370 ENSMUST00000192545.6 Gm38370 (from geneSymbol) ENSMUST00000192545.1 ENSMUST00000192545.2 ENSMUST00000192545.3 ENSMUST00000192545.4 ENSMUST00000192545.5 uc292snd.1 uc292snd.2 uc292snd.1 uc292snd.2 
ENSMUST00000192546.2 Gm38068 ENSMUST00000192546.2 Gm38068 (from geneSymbol) ENSMUST00000192546.1 uc290klu.1 uc290klu.2 uc290klu.1 uc290klu.2 
ENSMUST00000192549.2 Gm37247 ENSMUST00000192549.2 Gm37247 (from geneSymbol) AK076766 ENSMUST00000192549.1 uc292lcl.1 uc292lcl.2 uc292lcl.1 uc292lcl.2 
ENSMUST00000192552.2 Gm37491 ENSMUST00000192552.2 Gm37491 (from geneSymbol) ENSMUST00000192552.1 uc287ouc.1 uc287ouc.2 uc287ouc.1 uc287ouc.2 
ENSMUST00000192554.6 Ighv1-52 ENSMUST00000192554.6 Ighv1-52 (from geneSymbol) A0A0A6YXC3 A0A0A6YXC3_MOUSE AY648598 ENSMUST00000192554.1 ENSMUST00000192554.2 ENSMUST00000192554.3 ENSMUST00000192554.4 ENSMUST00000192554.5 Ighv1-52 uc288kad.1 uc288kad.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kad.1 uc288kad.2 
ENSMUST00000192556.2 9430037O13Rik ENSMUST00000192556.2 9430037O13Rik (from geneSymbol) AK020458 ENSMUST00000192556.1 uc287ozj.1 uc287ozj.2 uc287ozj.1 uc287ozj.2 
ENSMUST00000192560.2 Gm38249 ENSMUST00000192560.2 Gm38249 (from geneSymbol) AK082172 ENSMUST00000192560.1 uc287gqh.1 uc287gqh.2 uc287gqh.1 uc287gqh.2 
ENSMUST00000192561.6 Lin9 ENSMUST00000192561.6 lin-9 DREAM MuvB core complex component, transcript variant 3 (from RefSeq NR_120498.1) Bara ENSMUST00000192561.1 ENSMUST00000192561.2 ENSMUST00000192561.3 ENSMUST00000192561.4 ENSMUST00000192561.5 LIN9_MOUSE NR_120498 Q5TKA0 Q8C735 Q8C9D8 Tgs1 uc007dwm.1 uc007dwm.2 uc007dwm.3 uc007dwm.4 uc007dwm.5 Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RB1 (By similarity). Nucleus, nucleoplasm Note=Found in perinucleolar structures. Associated with chromatin. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C735-1; Sequence=Displayed; Name=2; IsoId=Q8C735-2; Sequence=VSP_020513; Name=3; IsoId=Q8C735-3; Sequence=VSP_020511, VSP_020512; Belongs to the lin-9 family. Sequence=AAQ13712.1; Type=Erroneous initiation; Evidence=; Sequence=BAC31235.1; Type=Frameshift; Evidence=; reproduction DNA binding nucleus nucleoplasm transcription, DNA-templated cell cycle transcriptional repressor complex regulation of cell cycle DNA biosynthetic process uc007dwm.1 uc007dwm.2 uc007dwm.3 uc007dwm.4 uc007dwm.5 
ENSMUST00000192563.2 Gm37542 ENSMUST00000192563.2 Gm37542 (from geneSymbol) ENSMUST00000192563.1 uc287oqa.1 uc287oqa.2 uc287oqa.1 uc287oqa.2 
ENSMUST00000192568.2 Gm37885 ENSMUST00000192568.2 Gm37885 (from geneSymbol) AK039110 ENSMUST00000192568.1 uc007dyg.1 uc007dyg.2 uc007dyg.3 uc007dyg.1 uc007dyg.2 uc007dyg.3 
ENSMUST00000192569.2 4930540E01Rik ENSMUST00000192569.2 4930540E01Rik (from geneSymbol) AK016008 ENSMUST00000192569.1 uc292jzj.1 uc292jzj.2 uc292jzj.1 uc292jzj.2 
ENSMUST00000192571.2 Gm37855 ENSMUST00000192571.2 Gm37855 (from geneSymbol) AK148220 ENSMUST00000192571.1 uc290gir.1 uc290gir.2 uc290gir.1 uc290gir.2 
ENSMUST00000192572.2 Gm37146 ENSMUST00000192572.2 Gm37146 (from geneSymbol) ENSMUST00000192572.1 uc287hfu.1 uc287hfu.2 uc287hfu.1 uc287hfu.2 
ENSMUST00000192580.2 Gm37563 ENSMUST00000192580.2 Gm37563 (from geneSymbol) AK040445 ENSMUST00000192580.1 uc292kjm.1 uc292kjm.2 uc292kjm.1 uc292kjm.2 
ENSMUST00000192581.2 Gm38214 ENSMUST00000192581.2 Gm38214 (from geneSymbol) AK085565 ENSMUST00000192581.1 uc292jlw.1 uc292jlw.2 uc292jlw.1 uc292jlw.2 
ENSMUST00000192582.2 Gm37212 ENSMUST00000192582.2 Gm37212 (from geneSymbol) ENSMUST00000192582.1 uc287nag.1 uc287nag.2 uc287nag.1 uc287nag.2 
ENSMUST00000192589.2 Gm35070 ENSMUST00000192589.2 Gm35070 (from geneSymbol) ENSMUST00000192589.1 uc292slo.1 uc292slo.2 uc292slo.1 uc292slo.2 
ENSMUST00000192591.2 Ighv8-8 ENSMUST00000192591.2 Ighv8-8 (from geneSymbol) A0A0A6YXQ0 A0A0A6YXQ0_MOUSE AY648593 ENSMUST00000192591.1 Ighv8-8 uc288kar.1 uc288kar.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kar.1 uc288kar.2 
ENSMUST00000192592.2 Gm38010 ENSMUST00000192592.2 Gm38010 (from geneSymbol) AK048306 ENSMUST00000192592.1 uc287kbj.1 uc287kbj.2 uc287kbj.1 uc287kbj.2 
ENSMUST00000192593.2 Gm37516 ENSMUST00000192593.2 Gm37516 (from geneSymbol) AK084534 ENSMUST00000192593.1 uc287opu.1 uc287opu.2 uc287opu.1 uc287opu.2 
ENSMUST00000192601.2 Gm37337 ENSMUST00000192601.2 Gm37337 (from geneSymbol) ENSMUST00000192601.1 uc289pdv.1 uc289pdv.2 uc289pdv.1 uc289pdv.2 
ENSMUST00000192603.2 Gm38303 ENSMUST00000192603.2 Gm38303 (from geneSymbol) A0A0A6YWW8 A0A0A6YWW8_MOUSE AK165977 ENSMUST00000192603.1 Gm38303 uc290dvr.1 uc290dvr.2 uc290dvr.1 uc290dvr.2 
ENSMUST00000192605.2 Gm37698 ENSMUST00000192605.2 Gm37698 (from geneSymbol) ENSMUST00000192605.1 uc288mio.1 uc288mio.2 uc288mio.1 uc288mio.2 
ENSMUST00000192612.3 Gm37805 ENSMUST00000192612.3 Gm37805 (from geneSymbol) ENSMUST00000192612.1 ENSMUST00000192612.2 LF203822 uc292jrs.1 uc292jrs.2 uc292jrs.3 uc292jrs.1 uc292jrs.2 uc292jrs.3 
ENSMUST00000192613.2 Gm37897 ENSMUST00000192613.2 Gm37897 (from geneSymbol) ENSMUST00000192613.1 uc290fzv.1 uc290fzv.2 uc290fzv.1 uc290fzv.2 
ENSMUST00000192614.2 8030445P17Rik ENSMUST00000192614.2 8030445P17Rik (from geneSymbol) ENSMUST00000192614.1 uc287gyg.1 uc287gyg.2 uc287gyg.1 uc287gyg.2 
ENSMUST00000192617.2 Gm37700 ENSMUST00000192617.2 Gm37700 (from geneSymbol) ENSMUST00000192617.1 uc290zzp.1 uc290zzp.2 uc290zzp.1 uc290zzp.2 
ENSMUST00000192618.2 Gm37822 ENSMUST00000192618.2 Gm37822 (from geneSymbol) AK157428 ENSMUST00000192618.1 uc290ftl.1 uc290ftl.2 uc290ftl.1 uc290ftl.2 
ENSMUST00000192624.2 Gm37057 ENSMUST00000192624.2 Gm37057 (from geneSymbol) AK156839 ENSMUST00000192624.1 uc287mdm.1 uc287mdm.2 uc287mdm.1 uc287mdm.2 
ENSMUST00000192625.2 Gm10537 ENSMUST00000192625.2 Gm10537 (from geneSymbol) AK133141 ENSMUST00000192625.1 uc287lvg.1 uc287lvg.2 uc287lvg.1 uc287lvg.2 
ENSMUST00000192629.2 Gm37082 ENSMUST00000192629.2 Gm37082 (from geneSymbol) ENSMUST00000192629.1 uc292fnz.1 uc292fnz.2 uc292fnz.1 uc292fnz.2 
ENSMUST00000192631.2 Pcdha7 ENSMUST00000192631.2 protocadherin alpha 7 (from RefSeq NM_009957.2) ENSMUST00000192631.1 NM_009957 PCDA7_MOUSE Pcdha7 Q91Y13 uc008epc.1 uc008epc.2 uc008epc.3 uc008epc.4 uc008epc.5 uc008epc.6 Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (PubMed:27161523). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523). Forms homodimers in trans (molecules expressed by two different cells) (PubMed:27161523). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins (PubMed:27161523). Cell membrane ; Single-pass type I membrane protein Cadherin 1 to cadherin 4 domains mediate homophilic trans- interaction, the interaction with an identical protocadherin expressed by a neighboring cell (PubMed:27161523). This is a head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin (PubMed:27161523). The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane. Each cadherin domain binds three calcium ions (PubMed:27161523). calcium ion binding protein binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cell-cell recognition membrane integral component of membrane identical protein binding metal ion binding uc008epc.1 uc008epc.2 uc008epc.3 uc008epc.4 uc008epc.5 uc008epc.6 
ENSMUST00000192632.2 Gm36976 ENSMUST00000192632.2 Gm36976 (from geneSymbol) AK145433 ENSMUST00000192632.1 uc290eyz.1 uc290eyz.2 uc290eyz.1 uc290eyz.2 
ENSMUST00000192635.2 Gm38345 ENSMUST00000192635.2 Gm38345 (from geneSymbol) AK077675 ENSMUST00000192635.1 uc289rvb.1 uc289rvb.2 uc289rvb.1 uc289rvb.2 
ENSMUST00000192636.2 Gm37171 ENSMUST00000192636.2 Gm37171 (from geneSymbol) AK041548 ENSMUST00000192636.1 uc287ksi.1 uc287ksi.2 uc287ksi.1 uc287ksi.2 
ENSMUST00000192638.6 Ildr2 ENSMUST00000192638.6 immunoglobulin-like domain containing receptor 2, transcript variant 4 (from RefSeq NM_001357430.1) B5TVM2 B5TVM3 B5TVM4 B5TVM5 B5TVM6 B5TVM7 B5TVM8 B5TVM9 D1Ertd471e E9Q9U5 ENSMUST00000192638.1 ENSMUST00000192638.2 ENSMUST00000192638.3 ENSMUST00000192638.4 ENSMUST00000192638.5 ILDR2_MOUSE Ildr2 Ll NM_001357430 uc287nmq.1 uc287nmq.2 May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion (PubMed:33863978, PubMed:23826244). With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (PubMed:23239027). Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T- cell inhibitory activity (PubMed:29431694). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (PubMed:28785060). Interacts with MARVELD2 and OCLN (PubMed:23239027). Interacts with P4HB and HSPA5; the interaction with HSPA5 stabilizes ILDR2 expression (PubMed:33863978). Interacts (via C-terminus) with TRA2A, TRA2B and SRSF1 (PubMed:28785060). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Cell junction, tight junction Nucleus Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=B5TVM2-1; Sequence=Displayed; Name=2; IsoId=B5TVM2-2; Sequence=VSP_061358; Name=3; IsoId=B5TVM2-3; Sequence=VSP_061354; Name=4; IsoId=B5TVM2-4; Sequence=VSP_061355; Name=5; IsoId=B5TVM2-5; Sequence=VSP_061357; Name=6; IsoId=B5TVM2-6; Sequence=VSP_061359, VSP_061360; Name=7; IsoId=B5TVM2-7; Sequence=VSP_061356; Expressed in epithelial tissues, mainly in liver, kidney and colon. Steatotic liver with increased hepatic and circulating triglycerides and total cholesterol. Shows reduced expression of genes mediating synthesis and oxidation of hepatic lipids. Belongs to the immunoglobulin superfamily. LISCH7 family. It is uncertain whether Met-1 or Met-16 is the initiator. endoplasmic reticulum endoplasmic reticulum membrane response to glucose membrane integral component of membrane insulin secretion cell differentiation pancreas development homeostasis of number of cells within a tissue uc287nmq.1 uc287nmq.2 
ENSMUST00000192644.2 Gm37539 ENSMUST00000192644.2 Gm37539 (from geneSymbol) BC119563 ENSMUST00000192644.1 uc287mtn.1 uc287mtn.2 uc287mtn.1 uc287mtn.2 
ENSMUST00000192646.2 Gm38292 ENSMUST00000192646.2 Gm38292 (from geneSymbol) AK038103 ENSMUST00000192646.1 uc292fnv.1 uc292fnv.2 uc292fnv.1 uc292fnv.2 
ENSMUST00000192647.2 Gm37717 ENSMUST00000192647.2 Gm37717 (from geneSymbol) ENSMUST00000192647.1 uc287lhy.1 uc287lhy.2 uc287lhy.1 uc287lhy.2 
ENSMUST00000192652.2 Gm37135 ENSMUST00000192652.2 Gm37135 (from geneSymbol) ENSMUST00000192652.1 uc287hkj.1 uc287hkj.2 uc287hkj.1 uc287hkj.2 
ENSMUST00000192654.3 9430053O09Rik ENSMUST00000192654.3 9430053O09Rik (from geneSymbol) ENSMUST00000192654.1 ENSMUST00000192654.2 uc289fow.1 uc289fow.2 uc289fow.3 uc289fow.1 uc289fow.2 uc289fow.3 
ENSMUST00000192656.2 Gm37335 ENSMUST00000192656.2 Gm37335 (from geneSymbol) ENSMUST00000192656.1 uc287hga.1 uc287hga.2 uc287hga.1 uc287hga.2 
ENSMUST00000192658.2 Gm20045 ENSMUST00000192658.2 Gm20045 (from geneSymbol) ENSMUST00000192658.1 LF193010 uc287ntp.1 uc287ntp.2 uc287ntp.1 uc287ntp.2 
ENSMUST00000192660.2 D030062O11Rik ENSMUST00000192660.2 D030062O11Rik (from geneSymbol) ENSMUST00000192660.1 uc292jkb.1 uc292jkb.2 uc292jkb.1 uc292jkb.2 
ENSMUST00000192661.2 Gm38236 ENSMUST00000192661.2 Gm38236 (from geneSymbol) AK037759 ENSMUST00000192661.1 uc289wpx.1 uc289wpx.2 uc289wpx.1 uc289wpx.2 
ENSMUST00000192663.2 9530003O04Rik ENSMUST00000192663.2 9530003O04Rik (from geneSymbol) ENSMUST00000192663.1 uc289fpj.1 uc289fpj.2 uc289fpj.1 uc289fpj.2 
ENSMUST00000192668.2 Gm37595 ENSMUST00000192668.2 Gm37595 (from geneSymbol) ENSMUST00000192668.1 uc289tgz.1 uc289tgz.2 uc289tgz.1 uc289tgz.2 
ENSMUST00000192669.2 Gm38029 ENSMUST00000192669.2 Gm38029 (from geneSymbol) AK084280 ENSMUST00000192669.1 uc290egf.1 uc290egf.2 uc290egf.1 uc290egf.2 
ENSMUST00000192673.2 Gm37656 ENSMUST00000192673.2 Gm37656 (from geneSymbol) ENSMUST00000192673.1 uc292sku.1 uc292sku.2 uc292sku.1 uc292sku.2 
ENSMUST00000192679.2 Gm38122 ENSMUST00000192679.2 Gm38122 (from geneSymbol) AK051000 ENSMUST00000192679.1 uc287owq.1 uc287owq.2 uc287owq.1 uc287owq.2 
ENSMUST00000192680.2 Gm38081 ENSMUST00000192680.2 Gm38081 (from geneSymbol) AK046159 ENSMUST00000192680.1 uc287oeg.1 uc287oeg.2 uc287oeg.1 uc287oeg.2 
ENSMUST00000192682.2 Gm37672 ENSMUST00000192682.2 Gm37672 (from geneSymbol) ENSMUST00000192682.1 uc290fzf.1 uc290fzf.2 uc290fzf.1 uc290fzf.2 
ENSMUST00000192683.2 Gm30737 ENSMUST00000192683.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRL2) A0A087WRL2 A0A087WRL2_MOUSE ENSMUST00000192683.1 Gm21865 Gm30737 Gm35134 uc292sim.1 uc292sim.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292sim.1 uc292sim.2 
ENSMUST00000192684.6 Gm37690 ENSMUST00000192684.6 Gm37690 (from geneSymbol) ENSMUST00000192684.1 ENSMUST00000192684.2 ENSMUST00000192684.3 ENSMUST00000192684.4 ENSMUST00000192684.5 uc292snl.1 uc292snl.2 uc292snl.1 uc292snl.2 
ENSMUST00000192689.2 A930004J17Rik ENSMUST00000192689.2 A930004J17Rik (from geneSymbol) AK042496 ENSMUST00000192689.1 uc290qiu.1 uc290qiu.2 uc290qiu.1 uc290qiu.2 
ENSMUST00000192692.2 Gm19938 ENSMUST00000192692.2 Gm19938 (from geneSymbol) AK148737 ENSMUST00000192692.1 uc007aev.1 uc007aev.2 uc007aev.3 uc007aev.1 uc007aev.2 uc007aev.3 
ENSMUST00000192693.2 Gm32999 ENSMUST00000192693.2 Gm32999 (from geneSymbol) BC128342 ENSMUST00000192693.1 uc287nlr.1 uc287nlr.2 uc287nlr.1 uc287nlr.2 
ENSMUST00000192698.3 Atp6v1h ENSMUST00000192698.3 ATPase, H+ transporting, lysosomal V1 subunit H, transcript variant 2 (from RefSeq NM_001310442.1) A0A0A6YX18 A0A0A6YX18_MOUSE Atp6v1h ENSMUST00000192698.1 ENSMUST00000192698.2 NM_001310442 uc057atz.1 uc057atz.2 uc057atz.3 Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. Belongs to the V-ATPase H subunit family. vacuolar proton-transporting V-type ATPase, V1 domain ion transport proton-transporting ATPase activity, rotational mechanism hydrogen ion transmembrane transport uc057atz.1 uc057atz.2 uc057atz.3 
ENSMUST00000192700.3 Sirpb1a ENSMUST00000192700.3 signal-regulatory protein beta 1A (from RefSeq NM_001002898.1) D3YXM3 ENSMUST00000192700.1 ENSMUST00000192700.2 NM_001002898 Q6F5F2 Q6F5F2_MOUSE SIRP-beta Sirpb1a uc008oqw.1 uc008oqw.2 uc008oqw.3 molecular_function plasma membrane membrane integral component of membrane positive regulation of cell-cell adhesion intracellular signal transduction positive regulation of phagocytosis positive regulation of T cell activation uc008oqw.1 uc008oqw.2 uc008oqw.3 
ENSMUST00000192701.2 Gm38252 ENSMUST00000192701.2 Gm38252 (from geneSymbol) ENSMUST00000192701.1 uc290feb.1 uc290feb.2 uc290feb.1 uc290feb.2 
ENSMUST00000192703.2 9430062P05Rik ENSMUST00000192703.2 9430062P05Rik (from geneSymbol) ENSMUST00000192703.1 LF197731 uc292jos.1 uc292jos.2 uc292jos.1 uc292jos.2 
ENSMUST00000192705.2 Gm37133 ENSMUST00000192705.2 Gm37133 (from geneSymbol) ENSMUST00000192705.1 uc287gmn.1 uc287gmn.2 uc287gmn.1 uc287gmn.2 
ENSMUST00000192706.2 Gm36946 ENSMUST00000192706.2 Gm36946 (from geneSymbol) ENSMUST00000192706.1 uc288wak.1 uc288wak.2 uc288wak.1 uc288wak.2 
ENSMUST00000192711.2 Gm38209 ENSMUST00000192711.2 Gm38209 (from geneSymbol) ENSMUST00000192711.1 uc292sla.1 uc292sla.2 uc292sla.1 uc292sla.2 
ENSMUST00000192713.2 Gm37066 ENSMUST00000192713.2 Gm37066 (from geneSymbol) ENSMUST00000192713.1 uc287lhm.1 uc287lhm.2 uc287lhm.1 uc287lhm.2 
ENSMUST00000192715.6 Mynn ENSMUST00000192715.6 myoneurin, transcript variant 1 (from RefSeq NM_030557.3) ENSMUST00000192715.1 ENSMUST00000192715.2 ENSMUST00000192715.3 ENSMUST00000192715.4 ENSMUST00000192715.5 MYNN_MOUSE NM_030557 Q6P1G7 Q8BT55 Q922I4 Q99MD8 Q9CSA0 Q9CXJ8 uc008oux.1 uc008oux.2 uc008oux.3 uc008oux.4 Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99MD8-1; Sequence=Displayed; Name=2; IsoId=Q99MD8-2; Sequence=VSP_020220; Name=3; IsoId=Q99MD8-3; Sequence=VSP_020218, VSP_020219; Mainly expressed in the neuromuscular system. Located in and around synaptic myonuclei in adult muscle. Expression is dysregulated after nerve injury. Also found in the cerebellum, testis, heart, brain and liver. Expression is developmentally regulated in muscle and is associated with neuromuscular junctions during the late embryonic period. Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus metal ion binding cellular response to leukemia inhibitory factor uc008oux.1 uc008oux.2 uc008oux.3 uc008oux.4 
ENSMUST00000192720.2 Gm37159 ENSMUST00000192720.2 Gm37159 (from geneSymbol) ENSMUST00000192720.1 uc289wpw.1 uc289wpw.2 uc289wpw.1 uc289wpw.2 
ENSMUST00000192721.2 Gm38270 ENSMUST00000192721.2 Gm38270 (from geneSymbol) ENSMUST00000192721.1 uc292bdd.1 uc292bdd.2 uc292bdd.1 uc292bdd.2 
ENSMUST00000192723.2 Kcnk2 ENSMUST00000192723.2 potassium channel, subfamily K, member 2, transcript variant 2 (from RefSeq NM_010607.4) ENSMUST00000192723.1 KCNK2_MOUSE NM_010607 P97438 Q4VQI2 uc011wyj.1 uc011wyj.2 uc011wyj.3 uc011wyj.4 Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2 (PubMed:24496152). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (PubMed:24496152). Inhibited by barium (PubMed:9003761). Activated by volatile general anesthetics such as chloroform, diethyl ether, halothane and isoflurane (PubMed:10321245). Kinetic parameters: Note=Channel activation is extremely rapid (PubMed:9003761). Single channel conductance is about 14 pS (PubMed:9003761). ; Homodimer; disulfide-linked (PubMed:24496152). Heterodimer with KCNK1; disulfide-linked (PubMed:24496152). Interacts with BVES; the interaction enhances KCNK2 surface expression and is inhibited by cAMP (PubMed:22354168, PubMed:26642364). P97438; D3YVF0: Akap5; NbExp=4; IntAct=EBI-7091062, EBI-7091108; P97438; Q6PHU5: Sort1; NbExp=4; IntAct=EBI-7091062, EBI-6985663; [Isoform 1]: Cell membrane ulti-pass membrane protein Note=Location at the cell membrane requires interaction with KCNK1. Is not detected at the cell membrane when KCNK1 is absent. [Isoform 2]: Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=TREK-1b; IsoId=P97438-1; Sequence=Displayed; Name=2; Synonyms=TREK-1a; IsoId=P97438-2; Sequence=VSP_053951; Detected in hippocampus astrocytes (at protein level) (PubMed:24496152). High expression in brain and lung. Also detected in kidney, heart and skeletal muscle. Not detected in liver. In the brain, highest expression in olfactory bulb, hippocampus and cerebellum. Phosphorylation at Ser-348 controls the reversible conversion from a leak channel to a voltage-dependent channel. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. cardiac ventricle development voltage-gated potassium channel activity potassium channel activity protein binding nucleus endoplasmic reticulum plasma membrane integral component of plasma membrane ion transport potassium ion transport G-protein coupled receptor signaling pathway memory voltage-gated potassium channel complex response to mechanical stimulus cell surface positive regulation of cell death outward rectifier potassium channel activity membrane integral component of membrane apical plasma membrane potassium channel inhibitor activity potassium ion leak channel activity stabilization of membrane potential axon regulation of membrane potential neuron projection neuronal cell body axon terminus calyx of Held response to axon injury negative regulation of cardiac muscle cell proliferation cellular response to hypoxia potassium ion transmembrane transport cochlea development astrocyte projection positive regulation of cellular response to hypoxia negative regulation of DNA biosynthetic process uc011wyj.1 uc011wyj.2 uc011wyj.3 uc011wyj.4 
ENSMUST00000192724.2 Ighv1-49 ENSMUST00000192724.2 Ighv1-49 (from geneSymbol) A0A0A6YWX2 A0A0A6YWX2_MOUSE AK007826 ENSMUST00000192724.1 Ighv1-49 uc288jzy.1 uc288jzy.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jzy.1 uc288jzy.2 
ENSMUST00000192728.2 Gm37296 ENSMUST00000192728.2 Gm37296 (from geneSymbol) DM175808 ENSMUST00000192728.1 uc288ymz.1 uc288ymz.2 uc288ymz.1 uc288ymz.2 
ENSMUST00000192733.2 Gm38046 ENSMUST00000192733.2 Gm38046 (from geneSymbol) ENSMUST00000192733.1 uc287pfl.1 uc287pfl.2 uc287pfl.1 uc287pfl.2 
ENSMUST00000192735.2 Gm7265 ENSMUST00000192735.2 Gm7265 (from geneSymbol) ENSMUST00000192735.1 LF204658 uc292irp.1 uc292irp.2 uc292irp.1 uc292irp.2 
ENSMUST00000192736.2 1700034J04Rik ENSMUST00000192736.2 1700034J04Rik (from geneSymbol) AK006597 ENSMUST00000192736.1 uc288ewx.1 uc288ewx.2 uc288ewx.1 uc288ewx.2 
ENSMUST00000192740.2 Gm37947 ENSMUST00000192740.2 Gm37947 (from geneSymbol) ENSMUST00000192740.1 uc288ygz.1 uc288ygz.2 uc288ygz.1 uc288ygz.2 
ENSMUST00000192741.2 Gm37592 ENSMUST00000192741.2 Gm37592 (from geneSymbol) ENSMUST00000192741.1 uc290ejm.1 uc290ejm.2 uc290ejm.1 uc290ejm.2 
ENSMUST00000192742.2 Gm37069 ENSMUST00000192742.2 Gm37069 (from geneSymbol) ENSMUST00000192742.1 uc287opp.1 uc287opp.2 uc287opp.1 uc287opp.2 
ENSMUST00000192743.2 Gm38330 ENSMUST00000192743.2 Gm38330 (from geneSymbol) AK156700 ENSMUST00000192743.1 uc287llz.1 uc287llz.2 uc287llz.1 uc287llz.2 
ENSMUST00000192746.2 Ighj2 ENSMUST00000192746.2 Ighj2 (from geneSymbol) A0A0A6YWJ8 A0A0A6YWJ8_MOUSE AY205868 ENSMUST00000192746.1 Ighj2 uc288jsb.1 uc288jsb.2 uc288jsb.1 uc288jsb.2 
ENSMUST00000192748.2 Gm37768 ENSMUST00000192748.2 Gm37768 (from geneSymbol) ENSMUST00000192748.1 uc287olk.1 uc287olk.2 uc287olk.1 uc287olk.2 
ENSMUST00000192749.2 Gm21440 ENSMUST00000192749.2 predicted gene, 21440 (from RefSeq NM_001373893.1) ENSMUST00000192749.1 Gm20737 Gm20772 Gm20777 Gm20793 Gm20831 Gm21425 Gm21440 NM_001373893 Q3TTD8 Q3TTD8_MOUSE uc029xrz.1 uc029xrz.2 uc029xrz.3 uc029xrz.4 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc029xrz.1 uc029xrz.2 uc029xrz.3 uc029xrz.4 
ENSMUST00000192751.2 Gm38282 ENSMUST00000192751.2 Gm38282 (from geneSymbol) ENSMUST00000192751.1 uc288wvb.1 uc288wvb.2 uc288wvb.1 uc288wvb.2 
ENSMUST00000192752.2 Gm37887 ENSMUST00000192752.2 Gm37887 (from geneSymbol) AK029515 ENSMUST00000192752.1 uc287pfi.1 uc287pfi.2 uc287pfi.1 uc287pfi.2 
ENSMUST00000192754.2 Gm37660 ENSMUST00000192754.2 Gm37660 (from geneSymbol) AK141709 ENSMUST00000192754.1 uc292int.1 uc292int.2 uc292int.1 uc292int.2 
ENSMUST00000192756.2 Gm36999 ENSMUST00000192756.2 Gm36999 (from geneSymbol) AK041605 ENSMUST00000192756.1 uc287jss.1 uc287jss.2 uc287jss.1 uc287jss.2 
ENSMUST00000192759.2 Gm37858 ENSMUST00000192759.2 Gm37858 (from geneSymbol) AK044823 ENSMUST00000192759.1 uc287ogm.1 uc287ogm.2 uc287ogm.1 uc287ogm.2 
ENSMUST00000192760.2 Gm9924 ENSMUST00000192760.2 predicted gene 9924 (from RefSeq NR_188771.1) ENSMUST00000192760.1 NR_188771 uc290udo.1 uc290udo.2 uc290udo.1 uc290udo.2 
ENSMUST00000192763.2 Gm37015 ENSMUST00000192763.2 Gm37015 (from geneSymbol) AK136256 ENSMUST00000192763.1 uc289ptk.1 uc289ptk.2 uc289ptk.1 uc289ptk.2 
ENSMUST00000192767.2 Gm38320 ENSMUST00000192767.2 Gm38320 (from geneSymbol) ENSMUST00000192767.1 LF195580 uc291fwa.1 uc291fwa.2 uc291fwa.1 uc291fwa.2 
ENSMUST00000192772.2 6430511E19Rik ENSMUST00000192772.2 6430511E19Rik (from geneSymbol) AK032249 ENSMUST00000192772.1 uc291srh.1 uc291srh.2 uc291srh.1 uc291srh.2 
ENSMUST00000192778.2 Gm32200 ENSMUST00000192778.2 predicted gene, 32200 (from RefSeq NR_151615.1) ENSMUST00000192778.1 NR_151615 uc287ozg.1 uc287ozg.2 uc287ozg.1 uc287ozg.2 
ENSMUST00000192780.2 2900069G24Rik ENSMUST00000192780.2 2900069G24Rik (from geneSymbol) ENSMUST00000192780.1 uc287onl.1 uc287onl.2 uc287onl.1 uc287onl.2 
ENSMUST00000192781.2 Gm37320 ENSMUST00000192781.2 Gm37320 (from geneSymbol) AK140313 ENSMUST00000192781.1 uc288ymw.1 uc288ymw.2 uc288ymw.1 uc288ymw.2 
ENSMUST00000192785.6 Gm37467 ENSMUST00000192785.6 Gm37467 (from geneSymbol) ENSMUST00000192785.1 ENSMUST00000192785.2 ENSMUST00000192785.3 ENSMUST00000192785.4 ENSMUST00000192785.5 uc292sia.1 uc292sia.2 uc292sia.1 uc292sia.2 
ENSMUST00000192790.3 Gm38144 ENSMUST00000192790.3 Gm38144 (from geneSymbol) AK033021 ENSMUST00000192790.1 ENSMUST00000192790.2 uc289axa.1 uc289axa.2 uc289axa.3 uc289axa.1 uc289axa.2 uc289axa.3 
ENSMUST00000192793.6 Pabpc4l ENSMUST00000192793.6 poly(A) binding protein, cytoplasmic 4-like, transcript variant 4 (from RefSeq NM_001416288.1) ENSMUST00000192793.1 ENSMUST00000192793.2 ENSMUST00000192793.3 ENSMUST00000192793.4 ENSMUST00000192793.5 G5E8X2 G5E8X2_MOUSE NM_001416288 Pabpc4l uc033htg.1 uc033htg.2 uc033htg.3 Nucleus nucleic acid binding RNA binding mRNA 3'-UTR binding nucleus cytoplasm cytosol poly(A) binding biological_process poly(U) RNA binding cytoplasmic stress granule ribonucleoprotein complex uc033htg.1 uc033htg.2 uc033htg.3 
ENSMUST00000192800.2 Gm38082 ENSMUST00000192800.2 Gm38082 (from geneSymbol) AK040891 ENSMUST00000192800.1 uc057bvq.1 uc057bvq.2 uc057bvq.3 uc057bvq.1 uc057bvq.2 uc057bvq.3 
ENSMUST00000192803.2 Gm37544 ENSMUST00000192803.2 Gm37544 (from geneSymbol) ENSMUST00000192803.1 FJ386436 uc292slk.1 uc292slk.2 uc292slk.1 uc292slk.2 
ENSMUST00000192806.2 Gm37222 ENSMUST00000192806.2 Gm37222 (from geneSymbol) ENSMUST00000192806.1 uc292rzb.1 uc292rzb.2 uc292rzb.1 uc292rzb.2 
ENSMUST00000192808.2 Gm37949 ENSMUST00000192808.2 Gm37949 (from geneSymbol) ENSMUST00000192808.1 uc287lxp.1 uc287lxp.2 uc287lxp.1 uc287lxp.2 
ENSMUST00000192813.2 Gm37438 ENSMUST00000192813.2 Gm37438 (from geneSymbol) ENSMUST00000192813.1 uc287scj.1 uc287scj.2 uc287scj.1 uc287scj.2 
ENSMUST00000192814.2 Gm38211 ENSMUST00000192814.2 Gm38211 (from geneSymbol) ENSMUST00000192814.1 LF192646 uc287hvf.1 uc287hvf.2 uc287hvf.1 uc287hvf.2 
ENSMUST00000192816.2 Gm37262 ENSMUST00000192816.2 Gm37262 (from geneSymbol) AK051187 ENSMUST00000192816.1 uc287jqq.1 uc287jqq.2 uc287jqq.1 uc287jqq.2 
ENSMUST00000192824.2 4933436E23Rik ENSMUST00000192824.2 RIKEN cDNA 4933436E23 gene (from RefSeq NR_040455.1) ENSMUST00000192824.1 NR_040455 uc029qto.1 uc029qto.2 uc029qto.1 uc029qto.2 
ENSMUST00000192826.2 Gm37893 ENSMUST00000192826.2 Gm37893 (from geneSymbol) AK028853 ENSMUST00000192826.1 uc287mnn.1 uc287mnn.2 uc287mnn.1 uc287mnn.2 
ENSMUST00000192828.2 Gm37326 ENSMUST00000192828.2 Gm37326 (from geneSymbol) AK082449 ENSMUST00000192828.1 uc292itk.1 uc292itk.2 uc292itk.1 uc292itk.2 
ENSMUST00000192836.2 Gm37036 ENSMUST00000192836.2 Gm37036 (from geneSymbol) AK051541 ENSMUST00000192836.1 uc287klj.1 uc287klj.2 uc287klj.1 uc287klj.2 
ENSMUST00000192839.2 Gm37902 ENSMUST00000192839.2 Gm37902 (from geneSymbol) AK081650 ENSMUST00000192839.1 uc287jqn.1 uc287jqn.2 uc287jqn.1 uc287jqn.2 
ENSMUST00000192843.2 A730062M13Rik ENSMUST00000192843.2 A730062M13Rik (from geneSymbol) AK043165 ENSMUST00000192843.1 uc292irx.1 uc292irx.2 uc292irx.1 uc292irx.2 
ENSMUST00000192845.2 Gm37465 ENSMUST00000192845.2 Gm37465 (from geneSymbol) ENSMUST00000192845.1 uc290feh.1 uc290feh.2 uc290feh.1 uc290feh.2 
ENSMUST00000192846.2 Gm37948 ENSMUST00000192846.2 Gm37948 (from geneSymbol) ENSMUST00000192846.1 uc292slg.1 uc292slg.2 uc292slg.1 uc292slg.2 
ENSMUST00000192856.6 Trbc1 ENSMUST00000192856.6 Trbc1 (from geneSymbol) A0A0A6YWV4 A0A0A6YWV4_MOUSE AK037453 ENSMUST00000192856.1 ENSMUST00000192856.2 ENSMUST00000192856.3 ENSMUST00000192856.4 ENSMUST00000192856.5 Trbc1 uc291dvt.1 uc291dvt.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane membrane integral component of membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc291dvt.1 uc291dvt.2 
ENSMUST00000192858.2 Gm37633 ENSMUST00000192858.2 Gm37633 (from geneSymbol) ENSMUST00000192858.1 uc287idg.1 uc287idg.2 uc287idg.1 uc287idg.2 
ENSMUST00000192860.2 A430073I11Rik ENSMUST00000192860.2 A430073I11Rik (from geneSymbol) AK079808 ENSMUST00000192860.1 uc287orm.1 uc287orm.2 uc287orm.1 uc287orm.2 
ENSMUST00000192862.2 Gm37789 ENSMUST00000192862.2 Gm37789 (from geneSymbol) ENSMUST00000192862.1 uc287kva.1 uc287kva.2 uc287kva.1 uc287kva.2 
ENSMUST00000192863.5 Norad ENSMUST00000192863.5 non-coding RNA activated by DNA damage (from RefSeq NR_024329.1) ENSMUST00000192863.1 ENSMUST00000192863.2 ENSMUST00000192863.3 ENSMUST00000192863.4 NR_024329 uc012chs.1 uc012chs.2 uc012chs.3 uc012chs.4 uc012chs.5 uc012chs.6 uc012chs.7 uc012chs.1 uc012chs.2 uc012chs.3 uc012chs.4 uc012chs.5 uc012chs.6 uc012chs.7 
ENSMUST00000192866.6 Rcor3 ENSMUST00000192866.6 REST corepressor 3, transcript variant 7 (from RefSeq NM_001403274.1) A0A0A6YXM5 A0A0A6YXM5_MOUSE ENSMUST00000192866.1 ENSMUST00000192866.2 ENSMUST00000192866.3 ENSMUST00000192866.4 ENSMUST00000192866.5 NM_001403274 Rcor3 uc057khu.1 uc057khu.2 uc057khu.3 Nucleus Belongs to the CoREST family. DNA binding nucleus uc057khu.1 uc057khu.2 uc057khu.3 
ENSMUST00000192868.2 Gm37679 ENSMUST00000192868.2 Gm37679 (from geneSymbol) AK036286 ENSMUST00000192868.1 uc287mxr.1 uc287mxr.2 uc287mxr.1 uc287mxr.2 
ENSMUST00000192871.2 Gm20557 ENSMUST00000192871.2 Gm20557 (from geneSymbol) AK030119 ENSMUST00000192871.1 uc290fan.1 uc290fan.2 uc290fan.1 uc290fan.2 
ENSMUST00000192877.2 Ighv5-15 ENSMUST00000192877.2 Ighv5-15 (from geneSymbol) A0A0A6YWC7 A0A0A6YWC7_MOUSE BC093501 ENSMUST00000192877.1 Ighv5-15 uc288jup.1 uc288jup.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jup.1 uc288jup.2 
ENSMUST00000192879.2 Gm38188 ENSMUST00000192879.2 Gm38188 (from geneSymbol) ENSMUST00000192879.1 uc287oyo.1 uc287oyo.2 uc287oyo.1 uc287oyo.2 
ENSMUST00000192886.6 Tcta ENSMUST00000192886.6 T cell leukemia translocation altered gene, transcript variant 2 (from RefSeq NM_001311156.2) A0A0A6YXI4 A0A0A6YXI4_MOUSE ENSMUST00000192886.1 ENSMUST00000192886.2 ENSMUST00000192886.3 ENSMUST00000192886.4 ENSMUST00000192886.5 NM_001311156 Tcta uc057ceh.1 uc057ceh.2 uc057ceh.3 May be required for cellular fusion during osteoclastogenesis. Membrane Belongs to the TCTA family. membrane integral component of membrane uc057ceh.1 uc057ceh.2 uc057ceh.3 
ENSMUST00000192889.2 5730488B01Rik ENSMUST00000192889.2 RIKEN cDNA 5730488B01 gene (from RefSeq NR_073462.1) ENSMUST00000192889.1 NR_073462 uc033ibu.1 uc033ibu.2 uc033ibu.1 uc033ibu.2 
ENSMUST00000192891.2 Gm37618 ENSMUST00000192891.2 Gm37618 (from geneSymbol) AK047274 ENSMUST00000192891.1 uc287hbt.1 uc287hbt.2 uc287hbt.1 uc287hbt.2 
ENSMUST00000192892.2 Gm21366 ENSMUST00000192892.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRK1) A0A087WRK1 A0A087WRK1_MOUSE BC049626 ENSMUST00000192892.1 Gm20814 Gm20835 Gm20850 Gm20855 Gm20869 Gm20870 Gm20883 Gm20894 Gm20896 Gm20897 Gm20903 Gm20905 Gm20906 Gm20908 Gm20916 Gm20920 Gm20929 Gm20931 Gm21317 Gm21366 Gm21409 Gm21477 Sly uc292soi.1 uc292soi.2 Belongs to the XLR/SYCP3 family. protein binding nucleus cytoplasm single fertilization sex determination regulation of gene expression spermatid differentiation uc292soi.1 uc292soi.2 
ENSMUST00000192895.2 Gm37023 ENSMUST00000192895.2 Gm37023 (from geneSymbol) AK040141 ENSMUST00000192895.1 uc292ioq.1 uc292ioq.2 uc292ioq.1 uc292ioq.2 
ENSMUST00000192896.2 Gm38095 ENSMUST00000192896.2 Gm38095 (from geneSymbol) ENSMUST00000192896.1 LF192526 uc291xmj.1 uc291xmj.2 uc291xmj.1 uc291xmj.2 
ENSMUST00000192900.2 Gm38001 ENSMUST00000192900.2 Gm38001 (from geneSymbol) ENSMUST00000192900.1 uc290duu.1 uc290duu.2 uc290duu.1 uc290duu.2 
ENSMUST00000192902.2 Gm37934 ENSMUST00000192902.2 Gm37934 (from geneSymbol) ENSMUST00000192902.1 uc287kzq.1 uc287kzq.2 uc287kzq.1 uc287kzq.2 
ENSMUST00000192904.2 Gm37333 ENSMUST00000192904.2 Gm37333 (from geneSymbol) AK046018 ENSMUST00000192904.1 uc287maf.1 uc287maf.2 uc287maf.1 uc287maf.2 
ENSMUST00000192908.2 Gm37678 ENSMUST00000192908.2 Gm37678 (from geneSymbol) ENSMUST00000192908.1 uc292lgo.1 uc292lgo.2 uc292lgo.1 uc292lgo.2 
ENSMUST00000192910.2 Gm37620 ENSMUST00000192910.2 Gm37620 (from geneSymbol) ENSMUST00000192910.1 uc291rjf.1 uc291rjf.2 uc291rjf.1 uc291rjf.2 
ENSMUST00000192911.2 Ighv2-6-8 ENSMUST00000192911.2 Ighv2-6-8 (from geneSymbol) A0A0A6YWY9 A0A0A6YWY9_MOUSE ENSMUST00000192911.1 Ighv2-6-8 uc288juj.1 uc288juj.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288juj.1 uc288juj.2 
ENSMUST00000192914.2 Gm37140 ENSMUST00000192914.2 Gm37140 (from geneSymbol) AK085847 ENSMUST00000192914.1 uc287ktc.1 uc287ktc.2 uc287ktc.1 uc287ktc.2 
ENSMUST00000192917.3 Gm37218 ENSMUST00000192917.3 Gm37218 (from geneSymbol) ENSMUST00000192917.1 ENSMUST00000192917.2 uc287opv.1 uc287opv.2 uc287opv.3 uc287opv.1 uc287opv.2 uc287opv.3 
ENSMUST00000192920.3 4930527J03Rik ENSMUST00000192920.3 RIKEN cDNA 4930527J03 gene (from RefSeq NR_175960.1) ENSMUST00000192920.1 ENSMUST00000192920.2 NR_175960 uc287ogw.1 uc287ogw.2 uc287ogw.1 uc287ogw.2 
ENSMUST00000192921.2 B230377A18Rik ENSMUST00000192921.2 B230377A18Rik (from geneSymbol) AK163565 ENSMUST00000192921.1 uc291aiu.1 uc291aiu.2 uc291aiu.1 uc291aiu.2 
ENSMUST00000192924.2 Gm37127 ENSMUST00000192924.2 Gm37127 (from geneSymbol) ENSMUST00000192924.1 LF192616 uc287hfh.1 uc287hfh.2 uc287hfh.1 uc287hfh.2 
ENSMUST00000192925.2 Gm37913 ENSMUST00000192925.2 Gm37913 (from geneSymbol) ENSMUST00000192925.1 uc290hfx.1 uc290hfx.2 uc290hfx.1 uc290hfx.2 
ENSMUST00000192926.2 Strit1 ENSMUST00000192926.2 small transmembrane regulator of ion transport 1, transcript variant 2 (from RefSeq NM_001369306.1) DWORF_MOUSE ENSMUST00000192926.1 NM_001369306 P0DN83 Strit1 uc290fpq.1 uc290fpq.2 Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity (PubMed:26816378, PubMed:30299255). Does not directly stimulate SERCA pump activity (PubMed:26816378). Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (PubMed:26816378, PubMed:30299255). Monomer (PubMed:30299255). Interacts with ATP2A1/SERCA1 (PubMed:26816378, PubMed:30299255). Sarcoplasmic reticulum membrane ; Single-pass membrane protein Highly expressed in heart (at protein level). Detected in heart and soleus, a postural muscle group of the hindlimb containing the highest enrichment of slow-twitch muscle fibers. Also expressed in diaphragm, which contains some slow-twitch fibers. Not detected in the quadriceps, a fast-twitch muscle group, or in cardiac atrial muscle. Not expressed in the prenatal heart but gradually increases in abundance postnatally. Mice produce offspring at expected Mendelian ratios. Slow-twitch skeletal muscle fibers display delayed Ca(2+) clearance and relaxation and reduced SERCA activity. No significant differences are observed in peak muscle force and no differences are observed in relaxation rates at low, non-tetanic stimulation frequencies. However at tetanus-inducing frequencies, relaxation rates are significantly slowed after tetanus. protein binding enzyme activator activity membrane integral component of membrane sarcoplasmic reticulum regulation of slow-twitch skeletal muscle fiber contraction sarcoplasmic reticulum membrane positive regulation of catalytic activity positive regulation of calcium ion import regulation of calcium-transporting ATPase activity positive regulation of calcium-transporting ATPase activity positive regulation of calcium ion import into sarcoplasmic reticulum uc290fpq.1 uc290fpq.2 
ENSMUST00000192928.2 Gm38285 ENSMUST00000192928.2 Gm38285 (from geneSymbol) AK158525 ENSMUST00000192928.1 uc291opb.1 uc291opb.2 uc291opb.1 uc291opb.2 
ENSMUST00000192929.6 Nr5a2 ENSMUST00000192929.6 nuclear receptor subfamily 5, group A, member 2, transcript variant 2 (from RefSeq NM_001159769.2) ENSMUST00000192929.1 ENSMUST00000192929.2 ENSMUST00000192929.3 ENSMUST00000192929.4 ENSMUST00000192929.5 NM_001159769 Nr5a2 Q1WLP7 Q1WLP7_MOUSE uc007cvb.1 uc007cvb.2 uc007cvb.3 uc007cvb.4 Nucleus Belongs to the nuclear hormone receptor family. NR5 subfamily. DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity nucleus regulation of transcription, DNA-templated zinc ion binding steroid hormone mediated signaling pathway sequence-specific DNA binding metal ion binding uc007cvb.1 uc007cvb.2 uc007cvb.3 uc007cvb.4 
ENSMUST00000192930.2 2610300A13Rik ENSMUST00000192930.2 2610300A13Rik (from geneSymbol) ENSMUST00000192930.1 uc287hnf.1 uc287hnf.2 uc287hnf.1 uc287hnf.2 
ENSMUST00000192931.2 Pcdhgb1 ENSMUST00000192931.2 protocadherin gamma subfamily B, 1 (from RefSeq NM_033574.4) ENSMUST00000192931.1 NM_033574 Pcdhgb1 Q91XX8 Q91XX8_MOUSE uc008eqo.1 uc008eqo.2 uc008eqo.3 uc008eqo.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding protein binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane growth cone uc008eqo.1 uc008eqo.2 uc008eqo.3 uc008eqo.4 
ENSMUST00000192937.2 Tigd5 ENSMUST00000192937.2 tigger transposable element derived 5 (from RefSeq NM_178646.4) ENSMUST00000192937.1 NM_178646 Q499M4 Q8BQA1 Q8C381 Q8CBD5 TIGD5_MOUSE uc007whp.1 uc007whp.2 Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q499M4-1; Sequence=Displayed; Name=2; IsoId=Q499M4-2; Sequence=VSP_042797; Belongs to the tigger transposable element derived protein family. Sequence=BAC29359.1; Type=Frameshift; Evidence=; Sequence=BAC39713.1; Type=Frameshift; Evidence=; molecular_function nucleic acid binding DNA binding cellular_component nucleus biological_process uc007whp.1 uc007whp.2 
ENSMUST00000192941.2 Gm36994 ENSMUST00000192941.2 Gm36994 (from geneSymbol) ENSMUST00000192941.1 uc288ppk.1 uc288ppk.2 uc288ppk.1 uc288ppk.2 
ENSMUST00000192943.2 Gm9916 ENSMUST00000192943.2 predicted gene 9916 (from RefSeq NR_189024.1) ENSMUST00000192943.1 NR_189024 uc290jcc.1 uc290jcc.2 uc290jcc.1 uc290jcc.2 
ENSMUST00000192947.2 Gm37701 ENSMUST00000192947.2 Gm37701 (from geneSymbol) AK052804 ENSMUST00000192947.1 uc289tcg.1 uc289tcg.2 uc289tcg.1 uc289tcg.2 
ENSMUST00000192952.2 Gm37920 ENSMUST00000192952.2 Gm37920 (from geneSymbol) AK041438 ENSMUST00000192952.1 uc287lgu.1 uc287lgu.2 uc287lgu.1 uc287lgu.2 
ENSMUST00000192953.2 Gm37582 ENSMUST00000192953.2 Gm37582 (from geneSymbol) ENSMUST00000192953.1 uc057apu.1 uc057apu.2 uc057apu.3 uc057apu.1 uc057apu.2 uc057apu.3 
ENSMUST00000192957.2 Gm36937 ENSMUST00000192957.2 Gm36937 (from geneSymbol) ENSMUST00000192957.1 uc287nyd.1 uc287nyd.2 uc287nyd.1 uc287nyd.2 
ENSMUST00000192958.2 Gm37302 ENSMUST00000192958.2 Gm37302 (from geneSymbol) ENSMUST00000192958.1 uc291otc.1 uc291otc.2 uc291otc.1 uc291otc.2 
ENSMUST00000192963.2 Gm37951 ENSMUST00000192963.2 Gm37951 (from geneSymbol) ENSMUST00000192963.1 uc292scu.1 uc292scu.2 uc292scu.1 uc292scu.2 
ENSMUST00000192966.2 Gm37087 ENSMUST00000192966.2 Gm37087 (from geneSymbol) AK029022 ENSMUST00000192966.1 uc290heh.1 uc290heh.2 uc290heh.1 uc290heh.2 
ENSMUST00000192968.2 Gm38251 ENSMUST00000192968.2 Gm38251 (from geneSymbol) AK034847 ENSMUST00000192968.1 uc287osv.1 uc287osv.2 uc287osv.1 uc287osv.2 
ENSMUST00000192970.2 Gm10517 ENSMUST00000192970.2 Gm10517 (from geneSymbol) AK138310 ENSMUST00000192970.1 uc287oph.1 uc287oph.2 uc287oph.1 uc287oph.2 
ENSMUST00000192972.2 Gm38004 ENSMUST00000192972.2 Gm38004 (from geneSymbol) AK029621 ENSMUST00000192972.1 uc292lkm.1 uc292lkm.2 uc292lkm.1 uc292lkm.2 
ENSMUST00000192973.2 Gm37329 ENSMUST00000192973.2 Gm37329 (from geneSymbol) AK051123 ENSMUST00000192973.1 uc287gdj.1 uc287gdj.2 uc287gdj.1 uc287gdj.2 
ENSMUST00000192974.2 Gm37297 ENSMUST00000192974.2 Gm37297 (from geneSymbol) AK082525 ENSMUST00000192974.1 uc287kgw.1 uc287kgw.2 uc287kgw.1 uc287kgw.2 
ENSMUST00000192978.2 1700030I03Rik ENSMUST00000192978.2 1700030I03Rik (from geneSymbol) ENSMUST00000192978.1 uc288hqw.1 uc288hqw.2 uc288hqw.1 uc288hqw.2 
ENSMUST00000192979.2 B230112G18Rik ENSMUST00000192979.2 B230112G18Rik (from geneSymbol) AK020967 ENSMUST00000192979.1 uc291ytg.1 uc291ytg.2 uc291ytg.1 uc291ytg.2 
ENSMUST00000192981.2 Gm37502 ENSMUST00000192981.2 Gm37502 (from geneSymbol) ENSMUST00000192981.1 uc287npn.1 uc287npn.2 uc287npn.1 uc287npn.2 
ENSMUST00000192982.2 Gm36957 ENSMUST00000192982.2 Gm36957 (from geneSymbol) ENSMUST00000192982.1 uc292kdf.1 uc292kdf.2 uc292kdf.1 uc292kdf.2 
ENSMUST00000192983.2 Gm36993 ENSMUST00000192983.2 Gm36993 (from geneSymbol) ENSMUST00000192983.1 uc292kmj.1 uc292kmj.2 uc292kmj.1 uc292kmj.2 
ENSMUST00000192984.6 Gm38182 ENSMUST00000192984.6 Gm38182 (from geneSymbol) AF464162 ENSMUST00000192984.1 ENSMUST00000192984.2 ENSMUST00000192984.3 ENSMUST00000192984.4 ENSMUST00000192984.5 uc289ovd.1 uc289ovd.2 uc289ovd.1 uc289ovd.2 
ENSMUST00000192993.2 Gm37110 ENSMUST00000192993.2 Gm37110 (from geneSymbol) AK135872 ENSMUST00000192993.1 uc287hbb.1 uc287hbb.2 uc287hbb.1 uc287hbb.2 
ENSMUST00000192994.2 Gm37123 ENSMUST00000192994.2 Gm37123 (from geneSymbol) AK135705 ENSMUST00000192994.1 uc290eji.1 uc290eji.2 uc290eji.1 uc290eji.2 
ENSMUST00000192996.2 Gm38150 ENSMUST00000192996.2 Gm38150 (from geneSymbol) ENSMUST00000192996.1 LF197795 uc292kvs.1 uc292kvs.2 uc292kvs.1 uc292kvs.2 
ENSMUST00000192997.2 Gm36931 ENSMUST00000192997.2 Gm36931 (from geneSymbol) AK038206 ENSMUST00000192997.1 uc289lvw.1 uc289lvw.2 uc289lvw.1 uc289lvw.2 
ENSMUST00000192999.2 Gm38362 ENSMUST00000192999.2 Gm38362 (from geneSymbol) AK045100 ENSMUST00000192999.1 uc290ehd.1 uc290ehd.2 uc290ehd.1 uc290ehd.2 
ENSMUST00000193001.2 Gm37881 ENSMUST00000193001.2 Gm37881 (from geneSymbol) ENSMUST00000193001.1 uc289tba.1 uc289tba.2 uc289tba.1 uc289tba.2 
ENSMUST00000193003.2 Trbv31 ENSMUST00000193003.2 Trbv31 (from geneSymbol) A0A0A6YW81 A0A0U1RVH3 A2NU22 A2NU22_MOUSE ENSMUST00000193003.1 JQ929653 Trbv31 uc009bpz.1 uc009bpz.2 uc009bpz.3 uc009bpz.4 uc009bpz.1 uc009bpz.2 uc009bpz.3 uc009bpz.4 
ENSMUST00000193009.2 Gm38207 ENSMUST00000193009.2 Gm38207 (from geneSymbol) ENSMUST00000193009.1 uc290hgk.1 uc290hgk.2 uc290hgk.1 uc290hgk.2 
ENSMUST00000193012.2 Gm37327 ENSMUST00000193012.2 Gm37327 (from geneSymbol) A0A0G2JDD5 A0A0G2JDD5_MOUSE ENSMUST00000193012.1 Gm37327 Ighd5-7 Ighd5-8 uc288jsr.1 uc288jsr.2 uc288jsr.1 uc288jsr.2 
ENSMUST00000193014.2 Gm10472 ENSMUST00000193014.2 Gm10472 (from geneSymbol) ENSMUST00000193014.1 uc290trv.1 uc290trv.2 uc290trv.1 uc290trv.2 
ENSMUST00000193015.2 Gm37446 ENSMUST00000193015.2 Gm37446 (from geneSymbol) ENSMUST00000193015.1 uc289otw.1 uc289otw.2 uc289otw.1 uc289otw.2 
ENSMUST00000193019.6 Gm37654 ENSMUST00000193019.6 Gm37654 (from geneSymbol) ENSMUST00000193019.1 ENSMUST00000193019.2 ENSMUST00000193019.3 ENSMUST00000193019.4 ENSMUST00000193019.5 uc292sip.1 uc292sip.2 uc292sip.1 uc292sip.2 
ENSMUST00000193021.2 Gm37004 ENSMUST00000193021.2 Gm37004 (from geneSymbol) ENSMUST00000193021.1 uc289xgj.1 uc289xgj.2 uc289xgj.1 uc289xgj.2 
ENSMUST00000193022.2 Gm38012 ENSMUST00000193022.2 Gm38012 (from geneSymbol) AB351862 ENSMUST00000193022.1 uc287iqh.1 uc287iqh.2 uc287iqh.1 uc287iqh.2 
ENSMUST00000193026.2 Gm37798 ENSMUST00000193026.2 Gm37798 (from geneSymbol) ENSMUST00000193026.1 uc292srq.1 uc292srq.2 uc292srq.1 uc292srq.2 
ENSMUST00000193027.2 Gm37852 ENSMUST00000193027.2 Gm37852 (from geneSymbol) ENSMUST00000193027.1 uc287vcm.1 uc287vcm.2 uc287vcm.1 uc287vcm.2 
ENSMUST00000193029.2 ENSMUSG00000121696 ENSMUST00000193029.2 ENSMUSG00000121696 (from geneSymbol) AK149612 ENSMUST00000193029.1 uc008eqj.1 uc008eqj.2 uc008eqj.1 uc008eqj.2 
ENSMUST00000193032.2 Gm37382 ENSMUST00000193032.2 Gm37382 (from geneSymbol) AK084428 ENSMUST00000193032.1 uc287ifr.1 uc287ifr.2 uc287ifr.1 uc287ifr.2 
ENSMUST00000193034.2 Gm37256 ENSMUST00000193034.2 Gm37256 (from geneSymbol) ENSMUST00000193034.1 uc290fzs.1 uc290fzs.2 uc290fzs.1 uc290fzs.2 
ENSMUST00000193036.2 Gm38227 ENSMUST00000193036.2 Gm38227 (from geneSymbol) AK155790 ENSMUST00000193036.1 uc290htu.1 uc290htu.2 uc290htu.1 uc290htu.2 
ENSMUST00000193037.2 Gm20236 ENSMUST00000193037.2 Gm20236 (from geneSymbol) ENSMUST00000193037.1 uc288vjh.1 uc288vjh.2 uc288vjh.1 uc288vjh.2 
ENSMUST00000193040.3 Gm38336 ENSMUST00000193040.3 Gm38336 (from geneSymbol) AK050761 ENSMUST00000193040.1 ENSMUST00000193040.2 uc287hfc.1 uc287hfc.2 uc287hfc.1 uc287hfc.2 
ENSMUST00000193041.2 Gm38283 ENSMUST00000193041.2 Gm38283 (from geneSymbol) AK080678 ENSMUST00000193041.1 uc287lfw.1 uc287lfw.2 uc287lfw.1 uc287lfw.2 
ENSMUST00000193052.2 A130048G24Rik ENSMUST00000193052.2 A130048G24Rik (from geneSymbol) ENSMUST00000193052.1 uc287iei.1 uc287iei.2 uc287iei.1 uc287iei.2 
ENSMUST00000193054.2 4930456G14Rik ENSMUST00000193054.2 4930456G14Rik (from geneSymbol) AK015474 ENSMUST00000193054.1 uc287hpi.1 uc287hpi.2 uc287hpi.1 uc287hpi.2 
ENSMUST00000193061.2 Trbj1-7 ENSMUST00000193061.2 Trbj1-7 (from geneSymbol) A0A0A6YVP1 A0A0A6YVP1_MOUSE AK153842 ENSMUST00000193061.1 Trbj1-7 uc291dvr.1 uc291dvr.2 uc291dvr.1 uc291dvr.2 
ENSMUST00000193062.2 Gm37345 ENSMUST00000193062.2 Gm37345 (from geneSymbol) ENSMUST00000193062.1 uc290ezq.1 uc290ezq.2 uc290ezq.1 uc290ezq.2 
ENSMUST00000193064.2 Trbv26 ENSMUST00000193064.2 Trbv26 (from geneSymbol) A0A0B4J1P5 A0A0B4J1P5_MOUSE AK083362 ENSMUST00000193064.1 Trbv26 uc009boo.1 uc009boo.2 uc009boo.3 immunological synapse uc009boo.1 uc009boo.2 uc009boo.3 
ENSMUST00000193065.2 Gm37979 ENSMUST00000193065.2 Gm37979 (from geneSymbol) AK042560 ENSMUST00000193065.1 uc290dzm.1 uc290dzm.2 uc290dzm.1 uc290dzm.2 
ENSMUST00000193067.2 Gm37599 ENSMUST00000193067.2 Gm37599 (from geneSymbol) ENSMUST00000193067.1 uc287mhk.1 uc287mhk.2 uc287mhk.1 uc287mhk.2 
ENSMUST00000193079.2 Gm37862 ENSMUST00000193079.2 Gm37862 (from geneSymbol) AK139121 ENSMUST00000193079.1 uc287gxw.1 uc287gxw.2 uc287gxw.1 uc287gxw.2 
ENSMUST00000193081.2 Gm37160 ENSMUST00000193081.2 Gm37160 (from geneSymbol) ENSMUST00000193081.1 uc289tec.1 uc289tec.2 uc289tec.1 uc289tec.2 
ENSMUST00000193082.2 Gm37086 ENSMUST00000193082.2 Gm37086 (from geneSymbol) AB343361 ENSMUST00000193082.1 uc287omo.1 uc287omo.2 uc287omo.1 uc287omo.2 
ENSMUST00000193087.2 Gm37193 ENSMUST00000193087.2 Gm37193 (from geneSymbol) ENSMUST00000193087.1 uc290fzh.1 uc290fzh.2 uc290fzh.1 uc290fzh.2 
ENSMUST00000193090.2 Gm38160 ENSMUST00000193090.2 Gm38160 (from geneSymbol) AK163877 ENSMUST00000193090.1 uc290fcw.1 uc290fcw.2 uc290fcw.1 uc290fcw.2 
ENSMUST00000193092.2 Gm37194 ENSMUST00000193092.2 Gm37194 (from geneSymbol) ENSMUST00000193092.1 uc288tke.1 uc288tke.2 uc288tke.1 uc288tke.2 
ENSMUST00000193094.6 Cr1l ENSMUST00000193094.6 complement C3b/C4b receptor 1 like, transcript variant 2 (from RefSeq NM_001355060.1) A0A0A6YY75 A0A0A6YY75_MOUSE Cr1l ENSMUST00000193094.1 ENSMUST00000193094.2 ENSMUST00000193094.3 ENSMUST00000193094.4 ENSMUST00000193094.5 NM_001355060 uc007eev.1 uc007eev.2 uc007eev.3 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc007eev.1 uc007eev.2 uc007eev.3 
ENSMUST00000193095.2 4930517J16Rik ENSMUST00000193095.2 4930517J16Rik (from geneSymbol) AK015815 ENSMUST00000193095.1 uc290mkd.1 uc290mkd.2 uc290mkd.1 uc290mkd.2 
ENSMUST00000193096.2 Gm37977 ENSMUST00000193096.2 Gm37977 (from geneSymbol) ENSMUST00000193096.1 uc287ind.1 uc287ind.2 uc287ind.1 uc287ind.2 
ENSMUST00000193099.2 Gm37911 ENSMUST00000193099.2 Gm37911 (from geneSymbol) AK052137 ENSMUST00000193099.1 uc287hbc.1 uc287hbc.2 uc287hbc.1 uc287hbc.2 
ENSMUST00000193100.2 Gm10129 ENSMUST00000193100.2 Gm10129 (from geneSymbol) AK037084 ENSMUST00000193100.1 uc288mds.1 uc288mds.2 uc288mds.1 uc288mds.2 
ENSMUST00000193103.2 Gm37667 ENSMUST00000193103.2 Gm37667 (from geneSymbol) ENSMUST00000193103.1 uc290prw.1 uc290prw.2 uc290prw.1 uc290prw.2 
ENSMUST00000193107.2 Gm37475 ENSMUST00000193107.2 Gm37475 (from geneSymbol) AK038462 ENSMUST00000193107.1 uc292leg.1 uc292leg.2 uc292leg.1 uc292leg.2 
ENSMUST00000193111.2 Gm37283 ENSMUST00000193111.2 Gm37283 (from geneSymbol) ENSMUST00000193111.1 uc287lmu.1 uc287lmu.2 uc287lmu.1 uc287lmu.2 
ENSMUST00000193112.2 Gm37879 ENSMUST00000193112.2 Gm37879 (from geneSymbol) AK040282 ENSMUST00000193112.1 uc292ion.1 uc292ion.2 uc292ion.1 uc292ion.2 
ENSMUST00000193116.2 Gm37899 ENSMUST00000193116.2 Gm37899 (from geneSymbol) ENSMUST00000193116.1 LF199330 uc057kpf.1 uc057kpf.2 uc057kpf.3 uc057kpf.1 uc057kpf.2 uc057kpf.3 
ENSMUST00000193117.3 Ralyl ENSMUST00000193117.3 RALY RNA binding protein-like, transcript variant 1 (from RefSeq NM_178631.4) ENSMUST00000193117.1 ENSMUST00000193117.2 NM_178631 Q8BTF8 Q8BTF9 Q8BTG1 RALYL_MOUSE uc008oqd.1 uc008oqd.2 uc008oqd.3 uc008oqd.4 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BTF8-1; Sequence=Displayed; Name=2; IsoId=Q8BTF8-2; Sequence=VSP_027727, VSP_027728; Belongs to the RRM HNRPC family. RALY subfamily. nucleic acid binding RNA binding nucleus biological_process identical protein binding uc008oqd.1 uc008oqd.2 uc008oqd.3 uc008oqd.4 
ENSMUST00000193122.2 Gm37966 ENSMUST00000193122.2 Gm37966 (from geneSymbol) ENSMUST00000193122.1 uc289lxz.1 uc289lxz.2 uc289lxz.1 uc289lxz.2 
ENSMUST00000193124.2 Gm37340 ENSMUST00000193124.2 Gm37340 (from geneSymbol) ENSMUST00000193124.1 uc289svr.1 uc289svr.2 uc289svr.1 uc289svr.2 
ENSMUST00000193126.2 Gm38173 ENSMUST00000193126.2 Gm38173 (from geneSymbol) AK037117 ENSMUST00000193126.1 uc057auf.1 uc057auf.2 uc057auf.3 uc057auf.1 uc057auf.2 uc057auf.3 
ENSMUST00000193127.2 Gm38366 ENSMUST00000193127.2 Gm38366 (from geneSymbol) ENSMUST00000193127.1 uc292lgn.1 uc292lgn.2 uc292lgn.1 uc292lgn.2 
ENSMUST00000193129.2 Gm37635 ENSMUST00000193129.2 Gm37635 (from geneSymbol) ENSMUST00000193129.1 FJ386436 uc292sln.1 uc292sln.2 uc292sln.1 uc292sln.2 
ENSMUST00000193131.2 Gm37958 ENSMUST00000193131.2 Gm37958 (from geneSymbol) ENSMUST00000193131.1 uc287hdn.1 uc287hdn.2 uc287hdn.1 uc287hdn.2 
ENSMUST00000193133.3 Ighv7-2 ENSMUST00000193133.3 Ighv7-2 (from geneSymbol) A0A0A6YX91 A0A0A6YX91_MOUSE ENSMUST00000193133.1 ENSMUST00000193133.2 Ighv7-2 U97569 uc288juz.1 uc288juz.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288juz.1 uc288juz.2 
ENSMUST00000193136.2 Gm37790 ENSMUST00000193136.2 Gm37790 (from geneSymbol) AK028309 ENSMUST00000193136.1 uc290bze.1 uc290bze.2 uc290bze.1 uc290bze.2 
ENSMUST00000193138.2 Gm20172 ENSMUST00000193138.2 Gm20172 (from geneSymbol) AK148788 ENSMUST00000193138.1 uc029qnn.1 uc029qnn.2 uc029qnn.3 uc029qnn.1 uc029qnn.2 uc029qnn.3 
ENSMUST00000193139.2 Gm37689 ENSMUST00000193139.2 Gm37689 (from geneSymbol) ENSMUST00000193139.1 uc290lav.1 uc290lav.2 uc290lav.1 uc290lav.2 
ENSMUST00000193145.2 Ighv8-6 ENSMUST00000193145.2 Ighv8-6 (from geneSymbol) A0A0A6YXA3 A0A0A6YXA3_MOUSE ENSMUST00000193145.1 Ighv8-6 uc288kag.1 uc288kag.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kag.1 uc288kag.2 
ENSMUST00000193147.2 Gm38065 ENSMUST00000193147.2 Gm38065 (from geneSymbol) ENSMUST00000193147.1 LF196720 uc291xmk.1 uc291xmk.2 uc291xmk.1 uc291xmk.2 
ENSMUST00000193148.2 Gm37400 ENSMUST00000193148.2 Gm37400 (from geneSymbol) ENSMUST00000193148.1 uc287gow.1 uc287gow.2 uc287gow.1 uc287gow.2 
ENSMUST00000193150.2 Gm37439 ENSMUST00000193150.2 Gm37439 (from geneSymbol) ENSMUST00000193150.1 uc287wul.1 uc287wul.2 uc287wul.1 uc287wul.2 
ENSMUST00000193157.2 Gm37909 ENSMUST00000193157.2 Gm37909 (from geneSymbol) ENSMUST00000193157.1 uc057auh.1 uc057auh.2 uc057auh.1 uc057auh.2 
ENSMUST00000193163.2 4930442P19Rik ENSMUST00000193163.2 4930442P19Rik (from geneSymbol) AK161360 ENSMUST00000193163.1 uc290uuf.1 uc290uuf.2 uc290uuf.1 uc290uuf.2 
ENSMUST00000193166.2 Gm37642 ENSMUST00000193166.2 Gm37642 (from geneSymbol) ENSMUST00000193166.1 uc287krm.1 uc287krm.2 uc287krm.1 uc287krm.2 
ENSMUST00000193169.2 Gm38228 ENSMUST00000193169.2 Gm38228 (from geneSymbol) ENSMUST00000193169.1 uc287hsi.1 uc287hsi.2 uc287hsi.1 uc287hsi.2 
ENSMUST00000193173.2 Gm37368 ENSMUST00000193173.2 Gm37368 (from geneSymbol) ENSMUST00000193173.1 uc287lvf.1 uc287lvf.2 uc287lvf.1 uc287lvf.2 
ENSMUST00000193176.2 Gm37456 ENSMUST00000193176.2 Gm37456 (from geneSymbol) AK156905 ENSMUST00000193176.1 uc287izs.1 uc287izs.2 uc287izs.1 uc287izs.2 
ENSMUST00000193177.2 Gm37521 ENSMUST00000193177.2 Gm37521 (from geneSymbol) DQ553062 ENSMUST00000193177.1 uc287khe.1 uc287khe.2 uc287khe.1 uc287khe.2 
ENSMUST00000193178.2 Gm10555 ENSMUST00000193178.2 Gm10555 (from geneSymbol) ENSMUST00000193178.1 uc287jpt.1 uc287jpt.2 uc287jpt.1 uc287jpt.2 
ENSMUST00000193181.2 Gm38368 ENSMUST00000193181.2 Gm38368 (from geneSymbol) ENSMUST00000193181.1 LF192974 uc287njz.1 uc287njz.2 uc287njz.1 uc287njz.2 
ENSMUST00000193184.2 Gm37425 ENSMUST00000193184.2 Gm37425 (from geneSymbol) ENSMUST00000193184.1 uc288pko.1 uc288pko.2 uc288pko.1 uc288pko.2 
ENSMUST00000193191.2 Gm37328 ENSMUST00000193191.2 Gm37328 (from geneSymbol) ENSMUST00000193191.1 uc287nal.1 uc287nal.2 uc287nal.1 uc287nal.2 
ENSMUST00000193194.3 AA914427 ENSMUST00000193194.3 EST AA914427 (from RefSeq NR_188871.1) ENSMUST00000193194.1 ENSMUST00000193194.2 NR_188871 uc289das.1 uc289das.2 uc289das.3 uc289das.1 uc289das.2 uc289das.3 
ENSMUST00000193198.2 Gm37671 ENSMUST00000193198.2 Gm37671 (from geneSymbol) ENSMUST00000193198.1 uc287mmm.1 uc287mmm.2 uc287mmm.1 uc287mmm.2 
ENSMUST00000193199.2 Gm37033 ENSMUST00000193199.2 Gm37033 (from geneSymbol) AK038311 ENSMUST00000193199.1 uc287okk.1 uc287okk.2 uc287okk.1 uc287okk.2 
ENSMUST00000193201.2 P2ry1 ENSMUST00000193201.2 purinergic receptor P2Y, G-protein coupled 1, transcript variant 2 (from RefSeq NM_001282016.1) ENSMUST00000193201.1 NM_001282016 P2ry1 Q544J5 Q544J5_MOUSE uc008pjk.1 uc008pjk.2 uc008pjk.3 uc008pjk.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. positive regulation of protein phosphorylation adenosine receptor signaling pathway G-protein coupled receptor activity ATP binding mitochondrion plasma membrane integral component of plasma membrane cilium signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration aging glial cell migration regulation of cell shape response to mechanical stimulus regulation of receptor activity negative regulation of norepinephrine secretion postsynaptic density membrane integral component of membrane basolateral plasma membrane apical plasma membrane sensory perception of pain signal transduction involved in regulation of gene expression platelet activation dendrite A1 adenosine receptor binding positive regulation of inositol trisphosphate biosynthetic process G-protein coupled purinergic nucleotide receptor signaling pathway wound healing eating behavior ADP binding cell body G-protein coupled purinergic nucleotide receptor activity ATP-activated adenosine receptor activity ADP-activated adenosine receptor activity postsynaptic membrane positive regulation of transcription from RNA polymerase II promoter positive regulation of hormone secretion protein heterodimerization activity negative regulation of binding positive regulation of penile erection positive regulation of ERK1 and ERK2 cascade response to growth factor cellular response to purine-containing compound protein localization to plasma membrane relaxation of muscle scaffold protein binding regulation of blood vessel diameter glutamatergic synapse integral component of presynaptic active zone membrane regulation of presynaptic cytosolic calcium ion concentration regulation of synaptic vesicle exocytosis uc008pjk.1 uc008pjk.2 uc008pjk.3 uc008pjk.4 
ENSMUST00000193207.2 Gm37983 ENSMUST00000193207.2 Gm37983 (from geneSymbol) ENSMUST00000193207.1 LF197678 uc292ipq.1 uc292ipq.2 uc292ipq.1 uc292ipq.2 
ENSMUST00000193209.3 Gm38293 ENSMUST00000193209.3 Gm38293 (from geneSymbol) ENSMUST00000193209.1 ENSMUST00000193209.2 uc287oll.1 uc287oll.2 uc287oll.3 uc287oll.1 uc287oll.2 uc287oll.3 
ENSMUST00000193210.6 Cox5b ENSMUST00000193210.6 cytochrome c oxidase subunit 5B (from RefSeq NM_009942.2) Cox5b Cox5b-ps ENSMUST00000193210.1 ENSMUST00000193210.2 ENSMUST00000193210.3 ENSMUST00000193210.4 ENSMUST00000193210.5 NM_009942 Q9D881 Q9D881_MOUSE uc007aqw.1 uc007aqw.2 uc007aqw.3 molecular_function cytochrome-c oxidase activity cellular_component mitochondrial envelope biological_process electron transport chain hydrogen ion transmembrane transport uc007aqw.1 uc007aqw.2 uc007aqw.3 
ENSMUST00000193214.2 Gm38299 ENSMUST00000193214.2 Gm38299 (from geneSymbol) AK046467 ENSMUST00000193214.1 uc289vgx.1 uc289vgx.2 uc289vgx.1 uc289vgx.2 
ENSMUST00000193223.2 Gm38066 ENSMUST00000193223.2 Gm38066 (from geneSymbol) AK048091 ENSMUST00000193223.1 uc290egy.1 uc290egy.2 uc290egy.1 uc290egy.2 
ENSMUST00000193225.2 Gm36989 ENSMUST00000193225.2 Gm36989 (from geneSymbol) AK041493 ENSMUST00000193225.1 uc289oqz.1 uc289oqz.2 uc289oqz.1 uc289oqz.2 
ENSMUST00000193236.2 C630004L07Rik ENSMUST00000193236.2 C630004L07Rik (from geneSymbol) AK049864 ENSMUST00000193236.1 uc290rih.1 uc290rih.2 uc290rih.1 uc290rih.2 
ENSMUST00000193239.2 Gm37767 ENSMUST00000193239.2 Gm37767 (from geneSymbol) AK081473 ENSMUST00000193239.1 uc287neu.1 uc287neu.2 uc287neu.1 uc287neu.2 
ENSMUST00000193241.2 Gm37567 ENSMUST00000193241.2 Gm37567 (from geneSymbol) AK145691 ENSMUST00000193241.1 uc287gfq.1 uc287gfq.2 uc287gfq.1 uc287gfq.2 
ENSMUST00000193244.2 Gm10568 ENSMUST00000193244.2 Gm10568 (from geneSymbol) AK140060 ENSMUST00000193244.1 uc287gdm.1 uc287gdm.2 uc287gdm.1 uc287gdm.2 
ENSMUST00000193245.3 Gm34882 ENSMUST00000193245.3 Gm34882 (from geneSymbol) ENSMUST00000193245.1 ENSMUST00000193245.2 uc287otb.1 uc287otb.2 uc287otb.3 uc287otb.1 uc287otb.2 uc287otb.3 
ENSMUST00000193246.2 Gm37726 ENSMUST00000193246.2 Gm37726 (from geneSymbol) ENSMUST00000193246.1 uc290ggp.1 uc290ggp.2 uc290ggp.1 uc290ggp.2 
ENSMUST00000193249.2 Gm37746 ENSMUST00000193249.2 Gm37746 (from geneSymbol) ENSMUST00000193249.1 uc290ezd.1 uc290ezd.2 uc290ezd.1 uc290ezd.2 
ENSMUST00000193250.2 Gm37111 ENSMUST00000193250.2 Gm37111 (from geneSymbol) ENSMUST00000193250.1 LF197868 uc292mfd.1 uc292mfd.2 uc292mfd.1 uc292mfd.2 
ENSMUST00000193253.2 Gm38377 ENSMUST00000193253.2 Gm38377 (from geneSymbol) ENSMUST00000193253.1 uc289wqd.1 uc289wqd.2 uc289wqd.1 uc289wqd.2 
ENSMUST00000193254.6 Apeh ENSMUST00000193254.6 acylpeptide hydrolase, transcript variant 1 (from RefSeq NM_146226.3) ACPH_MOUSE ENSMUST00000193254.1 ENSMUST00000193254.2 ENSMUST00000193254.3 ENSMUST00000193254.4 ENSMUST00000193254.5 G3X9I2 NM_146226 Q8K029 Q8R0M9 Q8R146 uc009rot.1 uc009rot.2 uc009rot.3 uc009rot.4 This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (By similarity). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Also, involved in the degradation of oxidized and glycated proteins (By similarity). Reaction=Cleavage of an N-acetyl or N-formyl amino acid from the N- terminus of a polypeptide.; EC=3.4.19.1; Evidence=; Homotetramerization is required for activity. Tetramerization results in the formation of a gated channel which is involved in substrate selection and substrate access to the catalytic sites. Homotetramer. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R146-1; Sequence=Displayed; Name=2; IsoId=Q8R146-2; Sequence=VSP_008866; Belongs to the peptidase S9C family. serine-type endopeptidase activity cytoplasm cytosol proteolysis serine-type peptidase activity omega peptidase activity hydrolase activity nuclear membrane identical protein binding beta-amyloid metabolic process uc009rot.1 uc009rot.2 uc009rot.3 uc009rot.4 
ENSMUST00000193259.2 Gm37234 ENSMUST00000193259.2 Gm37234 (from geneSymbol) AK049486 ENSMUST00000193259.1 uc292iry.1 uc292iry.2 uc292iry.1 uc292iry.2 
ENSMUST00000193261.2 D130019J16Rik ENSMUST00000193261.2 D130019J16Rik (from geneSymbol) AK037782 ENSMUST00000193261.1 uc287meb.1 uc287meb.2 uc287meb.1 uc287meb.2 
ENSMUST00000193263.2 Gm37742 ENSMUST00000193263.2 Gm37742 (from geneSymbol) ENSMUST00000193263.1 uc289tdr.1 uc289tdr.2 uc289tdr.1 uc289tdr.2 
ENSMUST00000193277.2 Gm37547 ENSMUST00000193277.2 Gm37547 (from geneSymbol) ENSMUST00000193277.1 uc292squ.1 uc292squ.2 uc292squ.1 uc292squ.2 
ENSMUST00000193280.2 Gm38099 ENSMUST00000193280.2 Gm38099 (from geneSymbol) ENSMUST00000193280.1 uc289joo.1 uc289joo.2 uc289joo.1 uc289joo.2 
ENSMUST00000193281.2 Gm37005 ENSMUST00000193281.2 Gm37005 (from geneSymbol) AK158545 ENSMUST00000193281.1 uc287gin.1 uc287gin.2 uc287gin.1 uc287gin.2 
ENSMUST00000193283.3 Gm37591 ENSMUST00000193283.3 Gm37591 (from geneSymbol) ENSMUST00000193283.1 ENSMUST00000193283.2 uc287hbn.1 uc287hbn.2 uc287hbn.3 uc287hbn.1 uc287hbn.2 uc287hbn.3 
ENSMUST00000193284.2 Gm38026 ENSMUST00000193284.2 Gm38026 (from geneSymbol) ENSMUST00000193284.1 uc287lkn.1 uc287lkn.2 uc287lkn.1 uc287lkn.2 
ENSMUST00000193285.2 Gm37986 ENSMUST00000193285.2 Gm37986 (from geneSymbol) AK080493 ENSMUST00000193285.1 uc287orj.1 uc287orj.2 uc287orj.1 uc287orj.2 
ENSMUST00000193286.6 Klhdc8b ENSMUST00000193286.6 kelch domain containing 8B, transcript variant 1 (from RefSeq NM_030075.2) ENSMUST00000193286.1 ENSMUST00000193286.2 ENSMUST00000193286.3 ENSMUST00000193286.4 ENSMUST00000193286.5 KLD8B_MOUSE NM_030075 Q9D2D9 uc009rpp.1 uc009rpp.2 uc009rpp.3 Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. Cytoplasm Midbody Note=In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis. cytoplasm cytosol cell cycle midbody intercellular bridge cell division nuclear chromosome segregation mitotic cytokinetic process uc009rpp.1 uc009rpp.2 uc009rpp.3 
ENSMUST00000193287.6 Zfp639 ENSMUST00000193287.6 Binds DNA and may function as a transcriptional repressor. (from UniProt Q99KZ6) A9X400 AK078000 ENSMUST00000193287.1 ENSMUST00000193287.2 ENSMUST00000193287.3 ENSMUST00000193287.4 ENSMUST00000193287.5 Q8BWU9 Q99KZ6 ZN639_MOUSE Zasc1 Znf639 uc008owf.1 uc008owf.2 uc008owf.3 uc008owf.4 Binds DNA and may function as a transcriptional repressor. Interacts with CTNNA2. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm positive regulation of cell growth protein self-association negative regulation by host of viral transcription positive regulation by host of viral transcription transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter viral entry into host cell metal ion binding uc008owf.1 uc008owf.2 uc008owf.3 uc008owf.4 
ENSMUST00000193293.2 Gm38275 ENSMUST00000193293.2 Gm38275 (from geneSymbol) AK159370 ENSMUST00000193293.1 uc289qzf.1 uc289qzf.2 uc289qzf.1 uc289qzf.2 
ENSMUST00000193294.2 Gm37590 ENSMUST00000193294.2 Gm37590 (from geneSymbol) ENSMUST00000193294.1 uc288rlo.1 uc288rlo.2 uc288rlo.1 uc288rlo.2 
ENSMUST00000193295.2 Gm54655 ENSMUST00000193295.2 Gm54655 (from geneSymbol) ENSMUST00000193295.1 uc288ppv.1 uc288ppv.2 uc288ppv.1 uc288ppv.2 
ENSMUST00000193299.2 ENSMUSG00000121694 ENSMUST00000193299.2 ENSMUSG00000121694 (from geneSymbol) ENSMUST00000193299.1 uc289otn.1 uc289otn.2 uc289otn.1 uc289otn.2 
ENSMUST00000193300.2 Gm37176 ENSMUST00000193300.2 Gm37176 (from geneSymbol) AK080162 ENSMUST00000193300.1 uc289lwi.1 uc289lwi.2 uc289lwi.1 uc289lwi.2 
ENSMUST00000193302.2 Gm37255 ENSMUST00000193302.2 Gm37255 (from geneSymbol) ENSMUST00000193302.1 LF193133 uc289tcy.1 uc289tcy.2 uc289tcy.1 uc289tcy.2 
ENSMUST00000193304.2 Gm37745 ENSMUST00000193304.2 Gm37745 (from geneSymbol) ENSMUST00000193304.1 LF192830 uc287len.1 uc287len.2 uc287len.1 uc287len.2 
ENSMUST00000193306.2 Gm20773 ENSMUST00000193306.2 Belongs to the SPIN/STSY family. (from UniProt A0A0A6YXW2) A0A0A6YXW2 A0A0A6YXW2_MOUSE ENSMUST00000193306.1 Gm20773 uc292sho.1 uc292sho.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sho.1 uc292sho.2 
ENSMUST00000193309.2 Gm38028 ENSMUST00000193309.2 Gm38028 (from geneSymbol) ENSMUST00000193309.1 uc292skn.1 uc292skn.2 uc292skn.1 uc292skn.2 
ENSMUST00000193310.2 Gm34068 ENSMUST00000193310.2 predicted gene, 34068 (from RefSeq NR_151520.1) ENSMUST00000193310.1 NR_151520 uc287orp.1 uc287orp.2 uc287orp.1 uc287orp.2 
ENSMUST00000193312.2 Gm38011 ENSMUST00000193312.2 Gm38011 (from geneSymbol) BC128354 ENSMUST00000193312.1 uc289vhx.1 uc289vhx.2 uc289vhx.1 uc289vhx.2 
ENSMUST00000193314.2 Gm37078 ENSMUST00000193314.2 Gm37078 (from geneSymbol) AK133062 ENSMUST00000193314.1 uc290fth.1 uc290fth.2 uc290fth.1 uc290fth.2 
ENSMUST00000193315.2 2610001A08Rik ENSMUST00000193315.2 2610001A08Rik (from geneSymbol) AK011250 ENSMUST00000193315.1 uc287wuh.1 uc287wuh.2 uc287wuh.1 uc287wuh.2 
ENSMUST00000193333.2 Gm37354 ENSMUST00000193333.2 Gm37354 (from geneSymbol) AK036115 ENSMUST00000193333.1 uc287hct.1 uc287hct.2 uc287hct.1 uc287hct.2 
ENSMUST00000193337.2 Sprr2a3 ENSMUST00000193337.2 Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (By similarity). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (PubMed:34735226). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (By similarity). (from UniProt Q9CQK8) BC056231 ENSMUST00000193337.1 O70553 Q9CQK8 SP2A1_MOUSE Sprr2a Sprr2a1 uc008qdq.1 uc008qdq.2 uc008qdq.3 uc008qdq.4 Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (By similarity). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (PubMed:34735226). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (By similarity). Secreted Secreted, extracellular space Cytoplasmic vesicle, secretory vesicle Note=Present in intestinal secretory epithelial cells and is secreted into the intestinal lumen. By type-2 cytokines IL4 and IL13 in response to helminth infection. Forms five pairs of intrachain disulfide bonds. Mice lacking Sprr2a1, Sprr2a2 and Sprr2a3 show an expansion of Gram-positive bacteria in the small intestinal lumen and mucus layer (PubMed:34735226). Mice were born in normal Mendelian ratios, are healthy and show normal intestinal morphology with no signs of inflammation in normal conditions (PubMed:34735226). They however show an increased abundance of Gram-positive bacteria in the small intestinal lumen, with a marked increase in the relative abundance of Lactobacillus, Turicibacter, and C.arthromitus (PubMed:34735226). At the same time, a reduction in the abundance of Bacteroidetes, a class of Gram-negative bacteria is observed (PubMed:34735226). Mice are more susceptible to L. monocytogenes infection (PubMed:34735226). Belongs to the cornifin (SPRR) family. cornified envelope structural constituent of cytoskeleton nucleus cytoplasm cytoskeleton organization regulation of cell shape epidermis development keratinocyte differentiation keratinization response to estradiol uc008qdq.1 uc008qdq.2 uc008qdq.3 uc008qdq.4 
ENSMUST00000193344.2 Gm37100 ENSMUST00000193344.2 Gm37100 (from geneSymbol) AK035756 ENSMUST00000193344.1 uc287iyj.1 uc287iyj.2 uc287iyj.1 uc287iyj.2 
ENSMUST00000193345.2 Gm37355 ENSMUST00000193345.2 Gm37355 (from geneSymbol) ENSMUST00000193345.1 uc290lig.1 uc290lig.2 uc290lig.1 uc290lig.2 
ENSMUST00000193347.2 Gm9694 ENSMUST00000193347.2 Gm9694 (from geneSymbol) ENSMUST00000193347.1 LF192939 uc287mub.1 uc287mub.2 uc287mub.1 uc287mub.2 
ENSMUST00000193349.2 Gm38014 ENSMUST00000193349.2 Gm38014 (from geneSymbol) AK028554 ENSMUST00000193349.1 uc289tdb.1 uc289tdb.2 uc289tdb.1 uc289tdb.2 
ENSMUST00000193350.2 Gm37120 ENSMUST00000193350.2 Gm37120 (from geneSymbol) AK138787 ENSMUST00000193350.1 uc287lqu.1 uc287lqu.2 uc287lqu.1 uc287lqu.2 
ENSMUST00000193352.2 Gm37094 ENSMUST00000193352.2 Gm37094 (from geneSymbol) ENSMUST00000193352.1 uc288vka.1 uc288vka.2 uc288vka.1 uc288vka.2 
ENSMUST00000193357.6 5830405F06Rik ENSMUST00000193357.6 5830405F06Rik (from geneSymbol) AK017898 ENSMUST00000193357.1 ENSMUST00000193357.2 ENSMUST00000193357.3 ENSMUST00000193357.4 ENSMUST00000193357.5 uc057acv.1 uc057acv.2 uc057acv.3 uc057acv.1 uc057acv.2 uc057acv.3 
ENSMUST00000193362.2 Gm37356 ENSMUST00000193362.2 Gm37356 (from geneSymbol) AK033969 ENSMUST00000193362.1 uc289tdq.1 uc289tdq.2 uc289tdq.1 uc289tdq.2 
ENSMUST00000193363.2 Gm34816 ENSMUST00000193363.2 predicted gene, 34816 (from RefSeq NR_151522.1) ENSMUST00000193363.1 NR_151522 uc287mgd.1 uc287mgd.2 uc287mgd.1 uc287mgd.2 
ENSMUST00000193369.2 Gm37152 ENSMUST00000193369.2 Gm37152 (from geneSymbol) AK086393 ENSMUST00000193369.1 uc287kau.1 uc287kau.2 uc287kau.1 uc287kau.2 
ENSMUST00000193378.2 Gm37470 ENSMUST00000193378.2 Gm37470 (from geneSymbol) AK041284 ENSMUST00000193378.1 uc287mfr.1 uc287mfr.2 uc287mfr.1 uc287mfr.2 
ENSMUST00000193380.2 BC055308 ENSMUST00000193380.2 BC055308 (from geneSymbol) AK141640 ENSMUST00000193380.1 uc287krk.1 uc287krk.2 uc287krk.1 uc287krk.2 
ENSMUST00000193381.2 Gm37092 ENSMUST00000193381.2 Gm37092 (from geneSymbol) ENSMUST00000193381.1 uc291gcr.1 uc291gcr.2 uc291gcr.1 uc291gcr.2 
ENSMUST00000193385.2 Gm37869 ENSMUST00000193385.2 Gm37869 (from geneSymbol) ENSMUST00000193385.1 uc287wtq.1 uc287wtq.2 uc287wtq.1 uc287wtq.2 
ENSMUST00000193386.6 Gm37462 ENSMUST00000193386.6 Gm37462 (from geneSymbol) ENSMUST00000193386.1 ENSMUST00000193386.2 ENSMUST00000193386.3 ENSMUST00000193386.4 ENSMUST00000193386.5 uc292smx.1 uc292smx.2 uc292smx.1 uc292smx.2 
ENSMUST00000193390.2 Gm20356 ENSMUST00000193390.2 predicted gene, 20356 (from RefSeq NR_040450.1) ENSMUST00000193390.1 NR_040450 uc029ump.1 uc029ump.2 uc029ump.3 uc029ump.1 uc029ump.2 uc029ump.3 
ENSMUST00000193392.2 Gm37211 ENSMUST00000193392.2 Gm37211 (from geneSymbol) AK082293 ENSMUST00000193392.1 uc287gxv.1 uc287gxv.2 uc287gxv.1 uc287gxv.2 
ENSMUST00000193393.2 Gm37058 ENSMUST00000193393.2 Gm37058 (from geneSymbol) AK148602 ENSMUST00000193393.1 uc287juk.1 uc287juk.2 uc287juk.1 uc287juk.2 
ENSMUST00000193397.2 Ighv6-7 ENSMUST00000193397.2 Ighv6-7 (from geneSymbol) A0A0A6YWU3 A0A0A6YWU3_MOUSE ENSMUST00000193397.1 Ighv6-7 L39085 uc288jwz.1 uc288jwz.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jwz.1 uc288jwz.2 
ENSMUST00000193401.2 Gm37272 ENSMUST00000193401.2 Gm37272 (from geneSymbol) ENSMUST00000193401.1 uc287oub.1 uc287oub.2 uc287oub.1 uc287oub.2 
ENSMUST00000193403.2 Gm10729 ENSMUST00000193403.2 Gm10729 (from geneSymbol) AK137296 ENSMUST00000193403.1 uc290fds.1 uc290fds.2 uc290fds.1 uc290fds.2 
ENSMUST00000193404.2 Pcdhga10 ENSMUST00000193404.2 protocadherin gamma subfamily A, 10 (from RefSeq NM_033593.4) ENSMUST00000193404.1 NM_033593 Pcdhga10 Q91XY9 Q91XY9_MOUSE uc008eqz.1 uc008eqz.2 uc008eqz.3 uc008eqz.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eqz.1 uc008eqz.2 uc008eqz.3 uc008eqz.4 
ENSMUST00000193407.2 Gm37243 ENSMUST00000193407.2 Gm37243 (from geneSymbol) ENSMUST00000193407.1 uc289xcf.1 uc289xcf.2 uc289xcf.1 uc289xcf.2 
ENSMUST00000193408.2 Ighv3-4 ENSMUST00000193408.2 Ighv3-4 (from geneSymbol) A0A0A6YXF1 A0A0A6YXF1_MOUSE ENSMUST00000193408.1 Ighv3-4 uc288jwc.1 uc288jwc.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jwc.1 uc288jwc.2 
ENSMUST00000193409.2 Gm37322 ENSMUST00000193409.2 Gm37322 (from geneSymbol) ENSMUST00000193409.1 uc289bxm.1 uc289bxm.2 uc289bxm.1 uc289bxm.2 
ENSMUST00000193413.2 Gm3081 ENSMUST00000193413.2 Gm3081 (from geneSymbol) ENSMUST00000193413.1 uc292kaq.1 uc292kaq.2 uc292kaq.1 uc292kaq.2 
ENSMUST00000193414.2 Pcdhga5 ENSMUST00000193414.2 protocadherin gamma subfamily A, 5 (from RefSeq NM_033588.5) ENSMUST00000193414.1 NM_033588 Pcdhga5 Q91XY3 Q91XY3_MOUSE uc008eqr.1 uc008eqr.2 uc008eqr.3 uc008eqr.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eqr.1 uc008eqr.2 uc008eqr.3 uc008eqr.4 
ENSMUST00000193416.2 4930578I07Rik ENSMUST00000193416.2 4930578I07Rik (from geneSymbol) ENSMUST00000193416.1 uc288vhh.1 uc288vhh.2 uc288vhh.1 uc288vhh.2 
ENSMUST00000193417.2 Gm37508 ENSMUST00000193417.2 Gm37508 (from geneSymbol) ENSMUST00000193417.1 uc289erl.1 uc289erl.2 uc289erl.1 uc289erl.2 
ENSMUST00000193419.2 Gm38361 ENSMUST00000193419.2 Gm38361 (from geneSymbol) ENSMUST00000193419.1 uc292skx.1 uc292skx.2 uc292skx.1 uc292skx.2 
ENSMUST00000193420.2 C630050I24Rik ENSMUST00000193420.2 C630050I24Rik (from geneSymbol) AK021281 ENSMUST00000193420.1 uc292daq.1 uc292daq.2 uc292daq.1 uc292daq.2 
ENSMUST00000193430.2 Gm37824 ENSMUST00000193430.2 Gm37824 (from geneSymbol) ENSMUST00000193430.1 uc289tdo.1 uc289tdo.2 uc289tdo.1 uc289tdo.2 
ENSMUST00000193434.2 2610012C04Rik ENSMUST00000193434.2 2610012C04Rik (from geneSymbol) AK011385 ENSMUST00000193434.1 uc287mae.1 uc287mae.2 uc287mae.1 uc287mae.2 
ENSMUST00000193438.6 Gm30045 ENSMUST00000193438.6 Gm30045 (from geneSymbol) ENSMUST00000193438.1 ENSMUST00000193438.2 ENSMUST00000193438.3 ENSMUST00000193438.4 ENSMUST00000193438.5 uc292sqi.1 uc292sqi.2 uc292sqi.1 uc292sqi.2 
ENSMUST00000193444.2 Gm37074 ENSMUST00000193444.2 Gm37074 (from geneSymbol) ENSMUST00000193444.1 uc287oyw.1 uc287oyw.2 uc287oyw.1 uc287oyw.2 
ENSMUST00000193456.2 4932431L22Rik ENSMUST00000193456.2 4932431L22Rik (from geneSymbol) ENSMUST00000193456.1 uc292uhu.1 uc292uhu.2 uc292uhu.1 uc292uhu.2 
ENSMUST00000193457.2 5730585A16Rik ENSMUST00000193457.2 5730585A16Rik (from geneSymbol) ENSMUST00000193457.1 uc289bwj.1 uc289bwj.2 uc289bwj.1 uc289bwj.2 
ENSMUST00000193458.2 Gm37443 ENSMUST00000193458.2 Gm37443 (from geneSymbol) AK039415 ENSMUST00000193458.1 uc290ele.1 uc290ele.2 uc290ele.1 uc290ele.2 
ENSMUST00000193462.2 Gm20731 ENSMUST00000193462.2 Gm20731 (from geneSymbol) ENSMUST00000193462.1 uc290oog.1 uc290oog.2 uc290oog.1 uc290oog.2 
ENSMUST00000193467.2 Gm38074 ENSMUST00000193467.2 Gm38074 (from geneSymbol) ENSMUST00000193467.1 uc290rog.1 uc290rog.2 uc290rog.1 uc290rog.2 
ENSMUST00000193468.2 4933436F18Rik ENSMUST00000193468.2 4933436F18Rik (from geneSymbol) ENSMUST00000193468.1 uc288hqv.1 uc288hqv.2 uc288hqv.1 uc288hqv.2 
ENSMUST00000193469.2 3110080O07Rik ENSMUST00000193469.2 3110080O07Rik (from geneSymbol) AK014267 ENSMUST00000193469.1 uc290fdy.1 uc290fdy.2 uc290fdy.1 uc290fdy.2 
ENSMUST00000193471.2 Gm37776 ENSMUST00000193471.2 Gm37776 (from geneSymbol) AK045468 ENSMUST00000193471.1 uc290fso.1 uc290fso.2 uc290fso.1 uc290fso.2 
ENSMUST00000193473.2 Gm38329 ENSMUST00000193473.2 Gm38329 (from geneSymbol) ENSMUST00000193473.1 uc287nam.1 uc287nam.2 uc287nam.1 uc287nam.2 
ENSMUST00000193475.2 Gm10152 ENSMUST00000193475.2 Gm10152 (from geneSymbol) AK051186 ENSMUST00000193475.1 uc291xqo.1 uc291xqo.2 uc291xqo.1 uc291xqo.2 
ENSMUST00000193479.2 Gm38265 ENSMUST00000193479.2 Gm38265 (from geneSymbol) ENSMUST00000193479.1 uc287jnq.1 uc287jnq.2 uc287jnq.1 uc287jnq.2 
ENSMUST00000193481.2 Gm37054 ENSMUST00000193481.2 Gm37054 (from geneSymbol) ENSMUST00000193481.1 uc288pat.1 uc288pat.2 uc288pat.1 uc288pat.2 
ENSMUST00000193484.2 Gm38101 ENSMUST00000193484.2 Gm38101 (from geneSymbol) ENSMUST00000193484.1 uc287oek.1 uc287oek.2 uc287oek.1 uc287oek.2 
ENSMUST00000193488.2 Gm38084 ENSMUST00000193488.2 Gm38084 (from geneSymbol) ENSMUST00000193488.1 uc292sgu.1 uc292sgu.2 uc292sgu.1 uc292sgu.2 
ENSMUST00000193492.2 1700012J22Rik ENSMUST00000193492.2 1700012J22Rik (from geneSymbol) AK005917 ENSMUST00000193492.1 uc288pmf.1 uc288pmf.2 uc288pmf.1 uc288pmf.2 
ENSMUST00000193494.2 Gm37752 ENSMUST00000193494.2 Gm37752 (from geneSymbol) AK029022 ENSMUST00000193494.1 uc290hej.1 uc290hej.2 uc290hej.1 uc290hej.2 
ENSMUST00000193497.2 Gm37972 ENSMUST00000193497.2 Gm37972 (from geneSymbol) ENSMUST00000193497.1 uc291znu.1 uc291znu.2 uc291znu.1 uc291znu.2 
ENSMUST00000193498.2 Gm10344 ENSMUST00000193498.2 Gm10344 (from geneSymbol) AK087866 ENSMUST00000193498.1 uc292qnu.1 uc292qnu.2 uc292qnu.1 uc292qnu.2 
ENSMUST00000193499.2 Gm37525 ENSMUST00000193499.2 Gm37525 (from geneSymbol) AK142651 ENSMUST00000193499.1 uc289spv.1 uc289spv.2 uc289spv.1 uc289spv.2 
ENSMUST00000193500.2 Gm37319 ENSMUST00000193500.2 Gm37319 (from geneSymbol) ENSMUST00000193500.1 uc287wse.1 uc287wse.2 uc287wse.1 uc287wse.2 
ENSMUST00000193501.2 Gm37710 ENSMUST00000193501.2 Gm37710 (from geneSymbol) AK153643 ENSMUST00000193501.1 uc292isc.1 uc292isc.2 uc292isc.1 uc292isc.2 
ENSMUST00000193506.2 Gm36963 ENSMUST00000193506.2 Gm36963 (from geneSymbol) ENSMUST00000193506.1 uc289fpb.1 uc289fpb.2 uc289fpb.1 uc289fpb.2 
ENSMUST00000193507.2 Gm37685 ENSMUST00000193507.2 Gm37685 (from geneSymbol) ENSMUST00000193507.1 uc290fzq.1 uc290fzq.2 uc290fzq.1 uc290fzq.2 
ENSMUST00000193511.2 5530400K19Rik ENSMUST00000193511.2 5530400K19Rik (from geneSymbol) DQ704516 ENSMUST00000193511.1 uc287mqz.1 uc287mqz.2 uc287mqz.1 uc287mqz.2 
ENSMUST00000193512.5 4930567H17Rik ENSMUST00000193512.5 RIKEN cDNA 4930567H17 gene (from RefSeq NR_157388.1) ENSMUST00000193512.1 ENSMUST00000193512.2 ENSMUST00000193512.3 ENSMUST00000193512.4 NR_157388 uc009tjg.1 uc009tjg.2 uc009tjg.3 uc009tjg.1 uc009tjg.2 uc009tjg.3 
ENSMUST00000193515.2 Gm37997 ENSMUST00000193515.2 Gm37997 (from geneSymbol) ENSMUST00000193515.1 uc289rho.1 uc289rho.2 uc289rho.1 uc289rho.2 
ENSMUST00000193516.2 Gm37971 ENSMUST00000193516.2 Gm37971 (from geneSymbol) AK083098 ENSMUST00000193516.1 uc290gcn.1 uc290gcn.2 uc290gcn.1 uc290gcn.2 
ENSMUST00000193517.6 Mbnl1 ENSMUST00000193517.6 Mbnl1 (from geneSymbol) A0A0A6YVV8 A0A0A6YVV8_MOUSE BC060031 ENSMUST00000193517.1 ENSMUST00000193517.2 ENSMUST00000193517.3 ENSMUST00000193517.4 ENSMUST00000193517.5 Mbnl1 uc290fnz.1 uc290fnz.2 metal ion binding uc290fnz.1 uc290fnz.2 
ENSMUST00000193520.2 Gm3807 ENSMUST00000193520.2 predicted gene 3807 (from RefSeq NR_188985.1) ENSMUST00000193520.1 NR_188985 uc288egn.1 uc288egn.2 uc288egn.1 uc288egn.2 
ENSMUST00000193521.2 Sprr5 ENSMUST00000193521.2 Sprr5 (from geneSymbol) 2310046K23Rik A0A0A6YVW6 A0A0A6YVW6_MOUSE AK009853 ENSMUST00000193521.1 Sprr5 uc290her.1 uc290her.2 uc290her.1 uc290her.2 
ENSMUST00000193524.2 Gm37498 ENSMUST00000193524.2 Gm37498 (from geneSymbol) AK039522 ENSMUST00000193524.1 uc290fbh.1 uc290fbh.2 uc290fbh.1 uc290fbh.2 
ENSMUST00000193527.2 Gm10531 ENSMUST00000193527.2 Gm10531 (from geneSymbol) AK132966 ENSMUST00000193527.1 uc287mwm.1 uc287mwm.2 uc287mwm.1 uc287mwm.2 
ENSMUST00000193528.2 Gm10657 ENSMUST00000193528.2 Gm10657 (from geneSymbol) AK132138 ENSMUST00000193528.1 uc292htd.1 uc292htd.2 uc292htd.1 uc292htd.2 
ENSMUST00000193529.2 Tdpoz9-ps1 ENSMUST00000193529.2 Belongs to the Tdpoz family. (from UniProt P0DMR6) ENSMUST00000193529.1 Gm9125 P0DMR6 Q717B3 Q71G58 Q8BZV7 Q8VI39 TDP1L_MOUSE uc290hgv.1 uc290hgv.2 Belongs to the Tdpoz family. nucleus cytoplasm ubiquitin-dependent protein catabolic process regulation of proteolysis ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process uc290hgv.1 uc290hgv.2 
ENSMUST00000193532.2 9430034N14Rik ENSMUST00000193532.2 9430034N14Rik (from geneSymbol) AK034769 ENSMUST00000193532.1 uc287mui.1 uc287mui.2 uc287mui.1 uc287mui.2 
ENSMUST00000193534.2 Gm37861 ENSMUST00000193534.2 Gm37861 (from geneSymbol) AK047065 ENSMUST00000193534.1 uc287mxq.1 uc287mxq.2 uc287mxq.1 uc287mxq.2 
ENSMUST00000193536.2 Gm38045 ENSMUST00000193536.2 Gm38045 (from geneSymbol) ENSMUST00000193536.1 uc288wlf.1 uc288wlf.2 uc288wlf.1 uc288wlf.2 
ENSMUST00000193537.2 C130023A14Rik ENSMUST00000193537.2 C130023A14Rik (from geneSymbol) AK039756 ENSMUST00000193537.1 uc289fpi.1 uc289fpi.2 uc289fpi.1 uc289fpi.2 
ENSMUST00000193540.2 Gm37145 ENSMUST00000193540.2 Gm37145 (from geneSymbol) ENSMUST00000193540.1 uc287nyf.1 uc287nyf.2 uc287nyf.1 uc287nyf.2 
ENSMUST00000193542.3 Gm37254 ENSMUST00000193542.3 Gm37254 (from geneSymbol) AK017966 ENSMUST00000193542.1 ENSMUST00000193542.2 uc287ovf.1 uc287ovf.2 uc287ovf.1 uc287ovf.2 
ENSMUST00000193545.2 Gm37314 ENSMUST00000193545.2 Gm37314 (from geneSymbol) ENSMUST00000193545.1 uc292kbg.1 uc292kbg.2 uc292kbg.1 uc292kbg.2 
ENSMUST00000193547.6 Ncam1 ENSMUST00000193547.6 neural cell adhesion molecule 1, transcript variant 3 (from RefSeq NM_001113204.2) A0A0A6YY47 A0A0A6YY47_MOUSE ENSMUST00000193547.1 ENSMUST00000193547.2 ENSMUST00000193547.3 ENSMUST00000193547.4 ENSMUST00000193547.5 NM_001113204 Ncam1 uc009pjf.1 uc009pjf.2 uc009pjf.3 uc009pjf.4 cell adhesion membrane integral component of membrane uc009pjf.1 uc009pjf.2 uc009pjf.3 uc009pjf.4 
ENSMUST00000193553.2 Gm37716 ENSMUST00000193553.2 Gm37716 (from geneSymbol) ENSMUST00000193553.1 uc291tcs.1 uc291tcs.2 uc291tcs.1 uc291tcs.2 
ENSMUST00000193554.3 Gm29999 ENSMUST00000193554.3 Gm29999 (from geneSymbol) BC100375 ENSMUST00000193554.1 ENSMUST00000193554.2 uc290geh.1 uc290geh.2 uc290geh.3 uc290geh.1 uc290geh.2 uc290geh.3 
ENSMUST00000193555.2 Gm38218 ENSMUST00000193555.2 Gm38218 (from geneSymbol) ENSMUST00000193555.1 uc287ixm.1 uc287ixm.2 uc287ixm.1 uc287ixm.2 
ENSMUST00000193562.2 Gm34217 ENSMUST00000193562.2 Gm34217 (from geneSymbol) ENSMUST00000193562.1 uc292sop.1 uc292sop.2 uc292sop.1 uc292sop.2 
ENSMUST00000193563.2 Gm37750 ENSMUST00000193563.2 Gm37750 (from geneSymbol) ENSMUST00000193563.1 uc292kio.1 uc292kio.2 uc292kio.1 uc292kio.2 
ENSMUST00000193564.2 Gm37736 ENSMUST00000193564.2 Gm37736 (from geneSymbol) ENSMUST00000193564.1 LF204861 uc291fwb.1 uc291fwb.2 uc291fwb.1 uc291fwb.2 
ENSMUST00000193570.3 Gm37650 ENSMUST00000193570.3 Gm37650 (from geneSymbol) AK076929 ENSMUST00000193570.1 ENSMUST00000193570.2 uc007eej.1 uc007eej.2 uc007eej.3 uc007eej.4 uc007eej.1 uc007eej.2 uc007eej.3 uc007eej.4 
ENSMUST00000193572.2 Gm38230 ENSMUST00000193572.2 Gm38230 (from geneSymbol) AK033124 ENSMUST00000193572.1 uc292jiz.1 uc292jiz.2 uc292jiz.1 uc292jiz.2 
ENSMUST00000193573.2 Gm38260 ENSMUST00000193573.2 Gm38260 (from geneSymbol) AK141013 ENSMUST00000193573.1 uc287gye.1 uc287gye.2 uc287gye.1 uc287gye.2 
ENSMUST00000193574.2 Gm37228 ENSMUST00000193574.2 Gm37228 (from geneSymbol) ENSMUST00000193574.1 uc290jvq.1 uc290jvq.2 uc290jvq.1 uc290jvq.2 
ENSMUST00000193576.2 Gm37248 ENSMUST00000193576.2 Gm37248 (from geneSymbol) AK138703 ENSMUST00000193576.1 uc289lvy.1 uc289lvy.2 uc289lvy.1 uc289lvy.2 
ENSMUST00000193577.2 Gm37372 ENSMUST00000193577.2 Gm37372 (from geneSymbol) ENSMUST00000193577.1 uc287kxa.1 uc287kxa.2 uc287kxa.1 uc287kxa.2 
ENSMUST00000193580.2 Gm37190 ENSMUST00000193580.2 Gm37190 (from geneSymbol) ENSMUST00000193580.1 uc290fai.1 uc290fai.2 uc290fai.1 uc290fai.2 
ENSMUST00000193584.2 Gm9931 ENSMUST00000193584.2 Gm9931 (from geneSymbol) ENSMUST00000193584.1 uc287mjv.1 uc287mjv.2 uc287mjv.1 uc287mjv.2 
ENSMUST00000193585.2 Gm38089 ENSMUST00000193585.2 Gm38089 (from geneSymbol) ENSMUST00000193585.1 uc287gyw.1 uc287gyw.2 uc287gyw.1 uc287gyw.2 
ENSMUST00000193592.2 Gm37223 ENSMUST00000193592.2 Gm37223 (from geneSymbol) ENSMUST00000193592.1 uc287ory.1 uc287ory.2 uc287ory.1 uc287ory.2 
ENSMUST00000193594.2 Gm38381 ENSMUST00000193594.2 Gm38381 (from geneSymbol) AK030176 ENSMUST00000193594.1 uc287noo.1 uc287noo.2 uc287noo.1 uc287noo.2 
ENSMUST00000193596.2 Gm37416 ENSMUST00000193596.2 Gm37416 (from geneSymbol) ENSMUST00000193596.1 uc289thb.1 uc289thb.2 uc289thb.1 uc289thb.2 
ENSMUST00000193601.2 2900092N22Rik ENSMUST00000193601.2 2900092N22Rik (from geneSymbol) ENSMUST00000193601.1 uc289tfr.1 uc289tfr.2 uc289tfr.1 uc289tfr.2 
ENSMUST00000193602.2 Gm38232 ENSMUST00000193602.2 Gm38232 (from geneSymbol) ENSMUST00000193602.1 uc291bdk.1 uc291bdk.2 uc291bdk.1 uc291bdk.2 
ENSMUST00000193603.6 Nlgn1 ENSMUST00000193603.6 neuroligin 1, transcript variant 1 (from RefSeq NM_138666.4) ENSMUST00000193603.1 ENSMUST00000193603.2 ENSMUST00000193603.3 ENSMUST00000193603.4 ENSMUST00000193603.5 Kiaa1070 NLGN1_MOUSE NM_138666 Q99K10 uc008otc.1 uc008otc.2 uc008otc.3 Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (PubMed:23716671). The protein is involved in nervous system development. Interacts with neurexins NRXN1, NRXN2 and NRXN3 (By similarity). Interaction with neurexins is mediated by heparan sulfate glycan modification on neurexin (PubMed:30100184). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with AIP1, GOPC and PDZRN3 (By similarity). Interacts with NLGN3. Q99K10; P97924-5: Kalrn; Xeno; NbExp=2; IntAct=EBI-775037, EBI-26961214; Q99K10; O14522: PTPRT; Xeno; NbExp=2; IntAct=EBI-775037, EBI-728180; Q99K10-1; P58400-1: NRXN1; Xeno; NbExp=3; IntAct=EBI-15675933, EBI-16513622; Cell membrane ; Single-pass type I membrane protein Postsynaptic density Synaptic cleft Synaptic cell membrane Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99K10-1; Sequence=Displayed; Name=2; IsoId=Q99K10-2; Sequence=VSP_007528, VSP_007529, VSP_007530; Brain and arteries (at protein level). Expressed in olfactory bulb. Detected in brain. Expressed in a circadian manner in the brain with highest expression seen at Zeitgeber time (ZT) 6 hours. No obvious phenotype, but mice present subtle behavorial changes with some deficits in spatial learning and memory. In addition, mice have reduced brain volume. Mice lacking both NLGN1 and NLGN2, or NLGN1 and NLGN3, are viable, but have impaired breathing, drastically reduced reproduction rates and striking deficits in raising their offspring. Mice lacking NLGN1, NLGN2 and NLGN3 are born at the expected Mendelian rate, but die shortly after birth due to respiratory failure. They do not show a significant change in the number of synapses, but synapse function is strongly impaired. Mice exhibit social novelty and fear-conditioning deficits and also show reduced wakefulness duration and altered EEG during wakefulness and sleep. Belongs to the type-B carboxylesterase/lipase family. Sequence=BAC65715.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; regulation of respiratory gaseous exchange by neurological system process protein binding Golgi apparatus plasma membrane integral component of plasma membrane protein targeting cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules neuron cell-cell adhesion nervous system development synapse assembly external side of plasma membrane cell surface positive regulation of circadian sleep/wake cycle, wakefulness postsynaptic density membrane integral component of membrane synaptic vesicle targeting calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules NMDA selective glutamate receptor complex cell junction PDZ domain binding dendrite neuron projection development positive regulation of synaptic transmission, GABAergic filopodium tip protein localization to synapse signaling receptor activity neurexin family protein binding dendritic spine dendritic shaft receptor complex establishment of protein localization synapse postsynaptic membrane regulation of neuron differentiation protein dimerization activity synaptic vesicle endocytosis synaptic vesicle transport rhythmic process cytoskeletal matrix organization at active zone modulation of synaptic transmission synapse organization cell adhesion molecule binding protein heterotetramerization positive regulation of filopodium assembly positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic excitatory synapse long-term synaptic potentiation positive regulation of dendritic spine development negative regulation of dendritic spine morphogenesis cellular response to calcium ion terminal button organization synaptic vesicle clustering postsynaptic membrane assembly presynaptic membrane assembly scaffold protein binding AMPA glutamate receptor clustering NMDA glutamate receptor clustering neurexin clustering involved in presynaptic membrane assembly postsynaptic density protein 95 clustering receptor localization to synapse presynapse retrograde trans-synaptic signaling by trans-synaptic protein complex glutamatergic synapse integral component of postsynaptic specialization membrane synaptic membrane adhesion positive regulation of ruffle assembly positive regulation of synaptic vesicle endocytosis positive regulation of protein localization to synapse positive regulation of intracellular signal transduction excitatory synapse assembly positive regulation of presynaptic active zone assembly positive regulation of synaptic vesicle exocytosis regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of synaptic vesicle clustering inhibitory postsynaptic potential uc008otc.1 uc008otc.2 uc008otc.3 
ENSMUST00000193604.2 1700054O19Rik ENSMUST00000193604.2 1700054O19Rik (from geneSymbol) DQ719662 ENSMUST00000193604.1 uc288rpn.1 uc288rpn.2 uc288rpn.1 uc288rpn.2 
ENSMUST00000193605.2 Gm37444 ENSMUST00000193605.2 Gm37444 (from geneSymbol) AK082969 ENSMUST00000193605.1 uc287gpa.1 uc287gpa.2 uc287gpa.1 uc287gpa.2 
ENSMUST00000193607.2 Gm37284 ENSMUST00000193607.2 Gm37284 (from geneSymbol) ENSMUST00000193607.1 uc292lke.1 uc292lke.2 uc292lke.1 uc292lke.2 
ENSMUST00000193608.2 Gm38333 ENSMUST00000193608.2 Gm38333 (from geneSymbol) ENSMUST00000193608.1 uc287uxc.1 uc287uxc.2 uc287uxc.1 uc287uxc.2 
ENSMUST00000193609.2 Gm37589 ENSMUST00000193609.2 Gm37589 (from geneSymbol) ENSMUST00000193609.1 uc290fod.1 uc290fod.2 uc290fod.1 uc290fod.2 
ENSMUST00000193614.2 E330011M16Rik ENSMUST00000193614.2 E330011M16Rik (from geneSymbol) AK143349 ENSMUST00000193614.1 uc287ieq.1 uc287ieq.2 uc287ieq.1 uc287ieq.2 
ENSMUST00000193616.2 Gm36979 ENSMUST00000193616.2 Gm36979 (from geneSymbol) ENSMUST00000193616.1 uc289zlg.1 uc289zlg.2 uc289zlg.1 uc289zlg.2 
ENSMUST00000193617.2 Gm38140 ENSMUST00000193617.2 Gm38140 (from geneSymbol) AK155907 ENSMUST00000193617.1 uc287lvp.1 uc287lvp.2 uc287lvp.1 uc287lvp.2 
ENSMUST00000193623.2 Gm37410 ENSMUST00000193623.2 Gm37410 (from geneSymbol) AK157619 ENSMUST00000193623.1 uc287gmz.1 uc287gmz.2 uc287gmz.1 uc287gmz.2 
ENSMUST00000193624.2 Gm37478 ENSMUST00000193624.2 Gm37478 (from geneSymbol) ENSMUST00000193624.1 uc287lhj.1 uc287lhj.2 uc287lhj.1 uc287lhj.2 
ENSMUST00000193626.2 Gm37612 ENSMUST00000193626.2 Gm37612 (from geneSymbol) ENSMUST00000193626.1 uc292krv.1 uc292krv.2 uc292krv.1 uc292krv.2 
ENSMUST00000193627.2 ENSMUSG00000121434 ENSMUST00000193627.2 ENSMUSG00000121434 (from geneSymbol) ENSMUST00000193627.1 uc287oay.1 uc287oay.2 uc287oay.1 uc287oay.2 
ENSMUST00000193633.6 Tdrd12 ENSMUST00000193633.6 tudor domain containing 12, transcript variant 2 (from RefSeq NM_001368387.1) A0A0A6YX17 A0A0A6YX17_MOUSE ENSMUST00000193633.1 ENSMUST00000193633.2 ENSMUST00000193633.3 ENSMUST00000193633.4 ENSMUST00000193633.5 NM_001368387 Tdrd12 uc291oni.1 uc291oni.2 Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; nucleic acid binding ATP binding uc291oni.1 uc291oni.2 
ENSMUST00000193635.2 Gm37629 ENSMUST00000193635.2 Gm37629 (from geneSymbol) ENSMUST00000193635.1 uc287gix.1 uc287gix.2 uc287gix.1 uc287gix.2 
ENSMUST00000193637.2 Gm37153 ENSMUST00000193637.2 Gm37153 (from geneSymbol) ENSMUST00000193637.1 uc290taq.1 uc290taq.2 uc290taq.1 uc290taq.2 
ENSMUST00000193639.2 Gm37457 ENSMUST00000193639.2 Gm37457 (from geneSymbol) ENSMUST00000193639.1 uc292jpp.1 uc292jpp.2 uc292jpp.1 uc292jpp.2 
ENSMUST00000193649.2 Gm19445 ENSMUST00000193649.2 Gm19445 (from geneSymbol) ENSMUST00000193649.1 uc290elf.1 uc290elf.2 uc290elf.1 uc290elf.2 
ENSMUST00000193652.2 Ighv5-16 ENSMUST00000193652.2 Ighv5-16 (from geneSymbol) A0A0B4J1P4 A0A0B4J1P4_MOUSE ENSMUST00000193652.1 Ighv5-16 uc288jur.1 uc288jur.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jur.1 uc288jur.2 
ENSMUST00000193653.2 Gm38087 ENSMUST00000193653.2 Gm38087 (from geneSymbol) ENSMUST00000193653.1 uc287xou.1 uc287xou.2 uc287xou.1 uc287xou.2 
ENSMUST00000193657.2 Gm38077 ENSMUST00000193657.2 Gm38077 (from geneSymbol) AK031993 ENSMUST00000193657.1 uc292kkc.1 uc292kkc.2 uc292kkc.1 uc292kkc.2 
ENSMUST00000193663.2 Gm37307 ENSMUST00000193663.2 Gm37307 (from geneSymbol) AK157570 ENSMUST00000193663.1 uc292jfu.1 uc292jfu.2 uc292jfu.1 uc292jfu.2 
ENSMUST00000193667.7 Gm37800 ENSMUST00000193667.7 Gm37800 (from geneSymbol) ENSMUST00000193667.1 ENSMUST00000193667.2 ENSMUST00000193667.3 ENSMUST00000193667.4 ENSMUST00000193667.5 ENSMUST00000193667.6 uc287osd.1 uc287osd.2 uc287osd.3 uc287osd.1 uc287osd.2 uc287osd.3 
ENSMUST00000193668.3 Gm37974 ENSMUST00000193668.3 Gm37974 (from geneSymbol) ENSMUST00000193668.1 ENSMUST00000193668.2 uc292kze.1 uc292kze.2 uc292kze.3 uc292kze.1 uc292kze.2 uc292kze.3 
ENSMUST00000193670.2 Gm37236 ENSMUST00000193670.2 Gm37236 (from geneSymbol) ENSMUST00000193670.1 uc292sah.1 uc292sah.2 uc292sah.1 uc292sah.2 
ENSMUST00000193672.3 A830029E22Rik ENSMUST00000193672.3 RIKEN cDNA A830029E22 gene (from RefSeq NR_138586.1) ENSMUST00000193672.1 ENSMUST00000193672.2 NR_138586 uc008pol.1 uc008pol.2 uc008pol.3 uc008pol.1 uc008pol.2 uc008pol.3 
ENSMUST00000193679.2 Gm37202 ENSMUST00000193679.2 Gm37202 (from geneSymbol) ENSMUST00000193679.1 uc290fek.1 uc290fek.2 uc290fek.1 uc290fek.2 
ENSMUST00000193683.6 Nme7 ENSMUST00000193683.6 NME/NM23 family member 7, transcript variant 1 (from RefSeq NM_138314.4) ENSMUST00000193683.1 ENSMUST00000193683.2 ENSMUST00000193683.3 ENSMUST00000193683.4 ENSMUST00000193683.5 NDK7_MOUSE NM_138314 Q9QXL8 uc007din.1 uc007din.2 uc007din.3 uc007din.4 uc007din.5 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Microtubule inner protein (MIP) part of the dynein- decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Cytoplasm, cytoskeleton, cilium axoneme Belongs to the NDK family. nucleotide binding epithelial cilium movement nucleoside diphosphate kinase activity ATP binding extracellular region centrosome nucleoside diphosphate phosphorylation GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process determination of left/right symmetry brain development nucleotide metabolic process kinase activity phosphorylation transferase activity ciliary basal body intraciliary transport metal ion binding ciliary receptor clustering involved in smoothened signaling pathway left/right pattern formation cellular response to leukemia inhibitory factor uc007din.1 uc007din.2 uc007din.3 uc007din.4 uc007din.5 
ENSMUST00000193684.2 Gm37558 ENSMUST00000193684.2 Gm37558 (from geneSymbol) ENSMUST00000193684.1 uc290fwq.1 uc290fwq.2 uc290fwq.1 uc290fwq.2 
ENSMUST00000193688.2 Gm36970 ENSMUST00000193688.2 Gm36970 (from geneSymbol) AK053967 ENSMUST00000193688.1 uc287kin.1 uc287kin.2 uc287kin.1 uc287kin.2 
ENSMUST00000193689.2 Gm37200 ENSMUST00000193689.2 Gm37200 (from geneSymbol) ENSMUST00000193689.1 uc292kij.1 uc292kij.2 uc292kij.1 uc292kij.2 
ENSMUST00000193690.2 Gm38047 ENSMUST00000193690.2 Gm38047 (from geneSymbol) ENSMUST00000193690.1 LF276542 uc290eyc.1 uc290eyc.2 uc290eyc.1 uc290eyc.2 
ENSMUST00000193691.2 Gm37623 ENSMUST00000193691.2 Gm37623 (from geneSymbol) ENSMUST00000193691.1 uc287hqf.1 uc287hqf.2 uc287hqf.1 uc287hqf.2 
ENSMUST00000193692.2 Gm38096 ENSMUST00000193692.2 Gm38096 (from geneSymbol) ENSMUST00000193692.1 uc290gfa.1 uc290gfa.2 uc290gfa.1 uc290gfa.2 
ENSMUST00000193705.3 Gm37336 ENSMUST00000193705.3 Gm37336 (from geneSymbol) ENSMUST00000193705.1 ENSMUST00000193705.2 uc287ojy.1 uc287ojy.2 uc287ojy.3 uc287ojy.1 uc287ojy.2 uc287ojy.3 
ENSMUST00000193707.2 2610105M22Rik ENSMUST00000193707.2 2610105M22Rik (from geneSymbol) ENSMUST00000193707.1 LF197500 uc292fqx.1 uc292fqx.2 uc292fqx.1 uc292fqx.2 
ENSMUST00000193717.2 Gm37747 ENSMUST00000193717.2 Gm37747 (from geneSymbol) ENSMUST00000193717.1 uc289wqb.1 uc289wqb.2 uc289wqb.1 uc289wqb.2 
ENSMUST00000193718.2 Gm37142 ENSMUST00000193718.2 Gm37142 (from geneSymbol) ENSMUST00000193718.1 uc287mhl.1 uc287mhl.2 uc287mhl.1 uc287mhl.2 
ENSMUST00000193725.3 Gm33222 ENSMUST00000193725.3 Gm33222 (from geneSymbol) ENSMUST00000193725.1 ENSMUST00000193725.2 uc287hfv.1 uc287hfv.2 uc287hfv.3 uc287hfv.1 uc287hfv.2 uc287hfv.3 
ENSMUST00000193728.3 Gm37469 ENSMUST00000193728.3 Gm37469 (from geneSymbol) AK050153 ENSMUST00000193728.1 ENSMUST00000193728.2 uc287nlt.1 uc287nlt.2 uc287nlt.3 uc287nlt.1 uc287nlt.2 uc287nlt.3 
ENSMUST00000193733.2 Gm37039 ENSMUST00000193733.2 Gm37039 (from geneSymbol) ENSMUST00000193733.1 uc057auq.1 uc057auq.2 uc057auq.1 uc057auq.2 
ENSMUST00000193734.6 Tbl1xr1 ENSMUST00000193734.6 F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity). (from UniProt Q8BHJ5) AK136255 ENSMUST00000193734.1 ENSMUST00000193734.2 ENSMUST00000193734.3 ENSMUST00000193734.4 ENSMUST00000193734.5 Ira1 Q3UWL6 Q8BHJ5 Q8CBG4 Q8VEG3 Q9EQD4 TBL1R_MOUSE Tblr1 uc012cnx.1 uc012cnx.2 F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity). Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4 (By similarity). Interacts with MECP2; bridges interaction between MECP2 and NCOR1 (PubMed:28348241). Interacts with USP44 (By similarity). Q8BHJ5; P51608: MECP2; Xeno; NbExp=4; IntAct=EBI-1216384, EBI-1189067; Nucleus The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes. Belongs to the WD repeat EBI family. histone deacetylase complex negative regulation of transcription from RNA polymerase II promoter blastocyst hatching response to dietary excess DNA binding transcription corepressor activity protein binding nucleus nucleoplasm chromatin organization regulation of transcription from RNA polymerase II promoter beta-catenin binding regulation of gene expression lipid catabolic process histone deacetylation transcriptional repressor complex multicellular organism growth histone binding proteasome-mediated ubiquitin-dependent protein catabolic process transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein N-terminus binding white fat cell differentiation adipose tissue development fat pad development mitotic spindle regulation of triglyceride metabolic process positive regulation of canonical Wnt signaling pathway uc012cnx.1 uc012cnx.2 
ENSMUST00000193735.2 Gm38137 ENSMUST00000193735.2 Gm38137 (from geneSymbol) ENSMUST00000193735.1 uc287ipl.1 uc287ipl.2 uc287ipl.1 uc287ipl.2 
ENSMUST00000193744.2 Gm38248 ENSMUST00000193744.2 Gm38248 (from geneSymbol) AK035325 ENSMUST00000193744.1 uc287lkh.1 uc287lkh.2 uc287lkh.1 uc287lkh.2 
ENSMUST00000193745.2 Gm37668 ENSMUST00000193745.2 Gm37668 (from geneSymbol) ENSMUST00000193745.1 uc287oed.1 uc287oed.2 uc287oed.1 uc287oed.2 
ENSMUST00000193746.2 Gm38059 ENSMUST00000193746.2 Gm38059 (from geneSymbol) AK079029 ENSMUST00000193746.1 uc291qgo.1 uc291qgo.2 uc291qgo.1 uc291qgo.2 
ENSMUST00000193748.2 Gm37260 ENSMUST00000193748.2 Gm37260 (from geneSymbol) AK132818 ENSMUST00000193748.1 uc292kcj.1 uc292kcj.2 uc292kcj.1 uc292kcj.2 
ENSMUST00000193750.2 Gm37115 ENSMUST00000193750.2 Gm37115 (from geneSymbol) AK051118 ENSMUST00000193750.1 uc287myl.1 uc287myl.2 uc287myl.1 uc287myl.2 
ENSMUST00000193751.2 Gm37624 ENSMUST00000193751.2 Gm37624 (from geneSymbol) ENSMUST00000193751.1 uc290rlm.1 uc290rlm.2 uc290rlm.1 uc290rlm.2 
ENSMUST00000193753.2 Gm37769 ENSMUST00000193753.2 Gm37769 (from geneSymbol) AK142704 ENSMUST00000193753.1 uc287iyr.1 uc287iyr.2 uc287iyr.1 uc287iyr.2 
ENSMUST00000193756.2 Gm37147 ENSMUST00000193756.2 Gm37147 (from geneSymbol) ENSMUST00000193756.1 uc292shd.1 uc292shd.2 uc292shd.1 uc292shd.2 
ENSMUST00000193760.2 Gm37106 ENSMUST00000193760.2 Gm37106 (from geneSymbol) AK042108 ENSMUST00000193760.1 uc287ofs.1 uc287ofs.2 uc287ofs.1 uc287ofs.2 
ENSMUST00000193762.2 A030005K14Rik ENSMUST00000193762.2 A030005K14Rik (from geneSymbol) A030005K14Rik A0A1Y7VNY1 A0A1Y7VNY1_MOUSE ENSMUST00000193762.1 uc287jtm.1 uc287jtm.2 uc287jtm.1 uc287jtm.2 
ENSMUST00000193764.2 Gm37600 ENSMUST00000193764.2 Gm37600 (from geneSymbol) ENSMUST00000193764.1 uc287kla.1 uc287kla.2 uc287kla.1 uc287kla.2 
ENSMUST00000193775.2 Gm37403 ENSMUST00000193775.2 Gm37403 (from geneSymbol) ENSMUST00000193775.1 uc287njg.1 uc287njg.2 uc287njg.1 uc287njg.2 
ENSMUST00000193777.6 Pcdha6 ENSMUST00000193777.6 protocadherin alpha 6 (from RefSeq NM_007767.4) ENSMUST00000193777.1 ENSMUST00000193777.2 ENSMUST00000193777.3 ENSMUST00000193777.4 ENSMUST00000193777.5 NM_007767 Pcdha6 Q91Y14 Q91Y14_MOUSE uc008epb.1 uc008epb.2 uc008epb.3 uc008epb.4 uc008epb.5 uc008epb.6 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epb.1 uc008epb.2 uc008epb.3 uc008epb.4 uc008epb.5 uc008epb.6 
ENSMUST00000193781.2 Gm37898 ENSMUST00000193781.2 Gm37898 (from geneSymbol) ENSMUST00000193781.1 uc292smf.1 uc292smf.2 uc292smf.1 uc292smf.2 
ENSMUST00000193782.3 Gm34106 ENSMUST00000193782.3 predicted gene, 34106 (from RefSeq NR_168657.1) ENSMUST00000193782.1 ENSMUST00000193782.2 NR_168657 uc292kug.1 uc292kug.2 uc292kug.3 uc292kug.1 uc292kug.2 uc292kug.3 
ENSMUST00000193790.2 Gm38382 ENSMUST00000193790.2 Gm38382 (from geneSymbol) AK029562 ENSMUST00000193790.1 uc287gtf.1 uc287gtf.2 uc287gtf.1 uc287gtf.2 
ENSMUST00000193794.3 Gm37422 ENSMUST00000193794.3 Gm37422 (from geneSymbol) AK029573 ENSMUST00000193794.1 ENSMUST00000193794.2 uc287oxc.1 uc287oxc.2 uc287oxc.3 uc287oxc.1 uc287oxc.2 uc287oxc.3 
ENSMUST00000193796.2 Gm36982 ENSMUST00000193796.2 Gm36982 (from geneSymbol) ENSMUST00000193796.1 uc287lha.1 uc287lha.2 uc287lha.1 uc287lha.2 
ENSMUST00000193799.2 Gm19331 ENSMUST00000193799.2 Gm19331 (from geneSymbol) AK079758 ENSMUST00000193799.1 uc288kaz.1 uc288kaz.2 uc288kaz.1 uc288kaz.2 
ENSMUST00000193802.2 Gm37266 ENSMUST00000193802.2 Gm37266 (from geneSymbol) ENSMUST00000193802.1 uc289lwh.1 uc289lwh.2 uc289lwh.1 uc289lwh.2 
ENSMUST00000193807.2 Gm37429 ENSMUST00000193807.2 Gm37429 (from geneSymbol) ENSMUST00000193807.1 uc287gfy.1 uc287gfy.2 uc287gfy.1 uc287gfy.2 
ENSMUST00000193809.2 Tug1 ENSMUST00000193809.2 taurine upregulated gene 1, transcript variant d (from RefSeq NM_001396521.1) A0A8Q0QWN6 A0A8Q0QWN6_MOUSE ENSMUST00000193809.1 NM_001396521 Tug1 uc287wfb.1 uc287wfb.2 uc287wfb.1 uc287wfb.2 
ENSMUST00000193812.2 4933401J01Rik ENSMUST00000193812.2 4933401J01Rik (from geneSymbol) AK016604 ENSMUST00000193812.1 uc287gdb.1 uc287gdb.2 uc287gdb.1 uc287gdb.2 
ENSMUST00000193814.2 Gm36967 ENSMUST00000193814.2 Gm36967 (from geneSymbol) ENSMUST00000193814.1 uc290avn.1 uc290avn.2 uc290avn.1 uc290avn.2 
ENSMUST00000193815.2 Gm37165 ENSMUST00000193815.2 Gm37165 (from geneSymbol) AK139218 ENSMUST00000193815.1 uc289ouj.1 uc289ouj.2 uc289ouj.1 uc289ouj.2 
ENSMUST00000193816.2 Gm37042 ENSMUST00000193816.2 Gm37042 (from geneSymbol) AK080018 ENSMUST00000193816.1 uc288yse.1 uc288yse.2 uc288yse.1 uc288yse.2 
ENSMUST00000193817.2 Gm37216 ENSMUST00000193817.2 Gm37216 (from geneSymbol) AK141432 ENSMUST00000193817.1 uc289pvg.1 uc289pvg.2 uc289pvg.1 uc289pvg.2 
ENSMUST00000193819.2 Gm37463 ENSMUST00000193819.2 Gm37463 (from geneSymbol) AK086732 ENSMUST00000193819.1 uc287ofw.1 uc287ofw.2 uc287ofw.1 uc287ofw.2 
ENSMUST00000193830.2 Gm36956 ENSMUST00000193830.2 Gm36956 (from geneSymbol) AK190916 ENSMUST00000193830.1 uc291xyh.1 uc291xyh.2 uc291xyh.1 uc291xyh.2 
ENSMUST00000193837.2 Gm37641 ENSMUST00000193837.2 Gm37641 (from geneSymbol) ENSMUST00000193837.1 uc288oza.1 uc288oza.2 uc288oza.1 uc288oza.2 
ENSMUST00000193840.2 Gm36951 ENSMUST00000193840.2 Gm36951 (from geneSymbol) AK081510 ENSMUST00000193840.1 uc287lmc.1 uc287lmc.2 uc287lmc.1 uc287lmc.2 
ENSMUST00000193842.2 Gm37436 ENSMUST00000193842.2 Gm37436 (from geneSymbol) ENSMUST00000193842.1 uc292kyt.1 uc292kyt.2 uc292kyt.1 uc292kyt.2 
ENSMUST00000193848.2 Gm37533 ENSMUST00000193848.2 Gm37533 (from geneSymbol) ENSMUST00000193848.1 uc290eyv.1 uc290eyv.2 uc290eyv.1 uc290eyv.2 
ENSMUST00000193851.2 Gm37064 ENSMUST00000193851.2 Gm37064 (from geneSymbol) AK083759 ENSMUST00000193851.1 uc287lmg.1 uc287lmg.2 uc287lmg.1 uc287lmg.2 
ENSMUST00000193855.2 Ighv1-19 ENSMUST00000193855.2 Ighv1-19 (from geneSymbol) A0A0A6YWX0 A0A0A6YWX0_MOUSE AB644395 ENSMUST00000193855.1 Ighv1-19 uc288jyh.1 uc288jyh.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jyh.1 uc288jyh.2 
ENSMUST00000193857.2 4933403L11Rik ENSMUST00000193857.2 4933403L11Rik (from geneSymbol) AK016639 ENSMUST00000193857.1 uc289szz.1 uc289szz.2 uc289szz.1 uc289szz.2 
ENSMUST00000193859.2 Gm37375 ENSMUST00000193859.2 Gm37375 (from geneSymbol) AK197646 ENSMUST00000193859.1 uc292jjz.1 uc292jjz.2 uc292jjz.1 uc292jjz.2 
ENSMUST00000193863.2 4930423C22Rik ENSMUST00000193863.2 4930423C22Rik (from geneSymbol) AK015186 ENSMUST00000193863.1 uc288hqq.1 uc288hqq.2 uc288hqq.1 uc288hqq.2 
ENSMUST00000193864.2 Gm37829 ENSMUST00000193864.2 Gm37829 (from geneSymbol) ENSMUST00000193864.1 uc291rzr.1 uc291rzr.2 uc291rzr.1 uc291rzr.2 
ENSMUST00000193865.2 Gm37970 ENSMUST00000193865.2 Gm37970 (from geneSymbol) ENSMUST00000193865.1 uc287lhd.1 uc287lhd.2 uc287lhd.1 uc287lhd.2 
ENSMUST00000193867.2 A730094K22Rik ENSMUST00000193867.2 A730094K22Rik (from geneSymbol) AK043426 ENSMUST00000193867.1 uc292jps.1 uc292jps.2 uc292jps.1 uc292jps.2 
ENSMUST00000193869.2 Pcdhga2 ENSMUST00000193869.2 protocadherin gamma subfamily A, 2 (from RefSeq NM_033585.2) ENSMUST00000193869.1 NM_033585 Pcdhga2 Q91XY6 Q91XY6_MOUSE uc008eqm.1 uc008eqm.2 uc008eqm.3 uc008eqm.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eqm.1 uc008eqm.2 uc008eqm.3 uc008eqm.4 
ENSMUST00000193871.2 Gm37851 ENSMUST00000193871.2 Gm37851 (from geneSymbol) AK155266 ENSMUST00000193871.1 uc289szx.1 uc289szx.2 uc289szx.1 uc289szx.2 
ENSMUST00000193873.2 Gm38116 ENSMUST00000193873.2 Gm38116 (from geneSymbol) ENSMUST00000193873.1 uc287gpp.1 uc287gpp.2 uc287gpp.1 uc287gpp.2 
ENSMUST00000193877.2 Gm37556 ENSMUST00000193877.2 Gm37556 (from geneSymbol) ENSMUST00000193877.1 uc290nzw.1 uc290nzw.2 uc290nzw.1 uc290nzw.2 
ENSMUST00000193881.2 Gm37199 ENSMUST00000193881.2 Gm37199 (from geneSymbol) ENSMUST00000193881.1 uc290fbl.1 uc290fbl.2 uc290fbl.1 uc290fbl.2 
ENSMUST00000193882.2 Gm6525 ENSMUST00000193882.2 Component of the large ribosomal subunit. (from UniProt A0A0A6YW33) A0A0A6YW33 A0A0A6YW33_MOUSE ENSMUST00000193882.1 Gm6525 uc290gfs.1 uc290gfs.2 Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL42 family. structural constituent of ribosome ribosome translation cytosolic large ribosomal subunit uc290gfs.1 uc290gfs.2 
ENSMUST00000193885.2 Gm6420 ENSMUST00000193885.2 Gm6420 (from geneSymbol) AK131727 ENSMUST00000193885.1 uc287gvo.1 uc287gvo.2 uc287gvo.1 uc287gvo.2 
ENSMUST00000193887.2 Gm37088 ENSMUST00000193887.2 Gm37088 (from geneSymbol) ENSMUST00000193887.1 uc287myt.1 uc287myt.2 uc287myt.1 uc287myt.2 
ENSMUST00000193891.2 Gm38108 ENSMUST00000193891.2 Gm38108 (from geneSymbol) ENSMUST00000193891.1 uc287orr.1 uc287orr.2 uc287orr.1 uc287orr.2 
ENSMUST00000193893.6 Ighv1-9 ENSMUST00000193893.6 Ighv1-9 (from geneSymbol) A0A0A6YW37 A0A0A6YW37_MOUSE ENSMUST00000193893.1 ENSMUST00000193893.2 ENSMUST00000193893.3 ENSMUST00000193893.4 ENSMUST00000193893.5 Ighv1-9 M12764 uc288jxq.1 uc288jxq.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jxq.1 uc288jxq.2 
ENSMUST00000193896.2 Gm34780 ENSMUST00000193896.2 Gm34780 (from geneSymbol) AK076670 ENSMUST00000193896.1 uc290fsa.1 uc290fsa.2 uc290fsa.1 uc290fsa.2 
ENSMUST00000193899.2 Pcdh11x ENSMUST00000193899.2 Pcdh11x (from geneSymbol) A0A0A6YWK0 A0A0A6YWK0_MOUSE AJ564976 ENSMUST00000193899.1 Pcdh11x uc009ueg.1 uc009ueg.2 uc009ueg.3 calcium ion binding protein binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules negative regulation of phosphatase activity membrane integral component of membrane uc009ueg.1 uc009ueg.2 uc009ueg.3 
ENSMUST00000193900.2 Gm37150 ENSMUST00000193900.2 Gm37150 (from geneSymbol) ENSMUST00000193900.1 uc292ipz.1 uc292ipz.2 uc292ipz.1 uc292ipz.2 
ENSMUST00000193901.6 Pcdh9 ENSMUST00000193901.6 protocadherin 9, transcript variant 4 (from RefSeq NM_001271800.2) A0A0A6YWY8 A0A0A6YWY8_MOUSE ENSMUST00000193901.1 ENSMUST00000193901.2 ENSMUST00000193901.3 ENSMUST00000193901.4 ENSMUST00000193901.5 NM_001271800 Pcdh9 uc007uuo.1 uc007uuo.2 uc007uuo.3 uc007uuo.4 This gene encodes a member of the protocadherin family, and cadherin superfamily, of transmembrane proteins containing cadherin domains. These proteins mediate cell adhesion in neural tissues in the presence of calcium. The encoded protein may be involved in signaling at neuronal synaptic junctions. Sharing a characteristic with other protocadherin genes, this gene has a notably large exon that encodes multiple cadherin domains and a transmembrane region. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]. calcium ion binding protein binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane growth cone cell-cell contact zone uc007uuo.1 uc007uuo.2 uc007uuo.3 uc007uuo.4 
ENSMUST00000193902.2 Gm4430 ENSMUST00000193902.2 Gm4430 (from geneSymbol) AK133995 ENSMUST00000193902.1 uc290ajn.1 uc290ajn.2 uc290ajn.1 uc290ajn.2 
ENSMUST00000193903.2 Gm37259 ENSMUST00000193903.2 Gm37259 (from geneSymbol) ENSMUST00000193903.1 uc289gkz.1 uc289gkz.2 uc289gkz.1 uc289gkz.2 
ENSMUST00000193906.2 Gm37269 ENSMUST00000193906.2 Gm37269 (from geneSymbol) ENSMUST00000193906.1 uc291jxs.1 uc291jxs.2 uc291jxs.1 uc291jxs.2 
ENSMUST00000193908.2 Gm37352 ENSMUST00000193908.2 Gm37352 (from geneSymbol) ENSMUST00000193908.1 LF197075 uc292bnb.1 uc292bnb.2 uc292bnb.1 uc292bnb.2 
ENSMUST00000193912.2 2900022M07Rik ENSMUST00000193912.2 2900022M07Rik (from geneSymbol) ENSMUST00000193912.1 uc287gym.1 uc287gym.2 uc287gym.1 uc287gym.2 
ENSMUST00000193913.2 Gm33142 ENSMUST00000193913.2 Gm33142 (from geneSymbol) AK084322 ENSMUST00000193913.1 uc292don.1 uc292don.2 uc292don.1 uc292don.2 
ENSMUST00000193915.2 Gm38034 ENSMUST00000193915.2 Gm38034 (from geneSymbol) ENSMUST00000193915.1 LF204803 uc290feq.1 uc290feq.2 uc290feq.1 uc290feq.2 
ENSMUST00000193917.2 Gm37749 ENSMUST00000193917.2 Gm37749 (from geneSymbol) ENSMUST00000193917.1 uc287mju.1 uc287mju.2 uc287mju.1 uc287mju.2 
ENSMUST00000193918.6 Gm37454 ENSMUST00000193918.6 Gm37454 (from geneSymbol) ENSMUST00000193918.1 ENSMUST00000193918.2 ENSMUST00000193918.3 ENSMUST00000193918.4 ENSMUST00000193918.5 uc292soz.1 uc292soz.2 uc292soz.1 uc292soz.2 
ENSMUST00000193928.2 Gm38056 ENSMUST00000193928.2 Gm38056 (from geneSymbol) AK158690 ENSMUST00000193928.1 uc287ifp.1 uc287ifp.2 uc287ifp.1 uc287ifp.2 
ENSMUST00000193929.2 Gm37461 ENSMUST00000193929.2 Gm37461 (from geneSymbol) ENSMUST00000193929.1 uc290fbm.1 uc290fbm.2 uc290fbm.1 uc290fbm.2 
ENSMUST00000193936.2 Ighv6-5 ENSMUST00000193936.2 Ighv6-5 (from geneSymbol) A0A0A6YWS9 A0A0A6YWS9_MOUSE ENSMUST00000193936.1 Ighv6-5 uc288jww.1 uc288jww.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jww.1 uc288jww.2 
ENSMUST00000193939.2 Gm37552 ENSMUST00000193939.2 Gm37552 (from geneSymbol) AK040241 ENSMUST00000193939.1 uc287mci.1 uc287mci.2 uc287mci.1 uc287mci.2 
ENSMUST00000193945.2 Gm2136 ENSMUST00000193945.2 Gm2136 (from geneSymbol) ENSMUST00000193945.1 uc290ezp.1 uc290ezp.2 uc290ezp.1 uc290ezp.2 
ENSMUST00000193946.2 6720464F23Rik ENSMUST00000193946.2 6720464F23Rik (from geneSymbol) ENSMUST00000193946.1 uc287nai.1 uc287nai.2 uc287nai.1 uc287nai.2 
ENSMUST00000193950.6 Ighv1-37 ENSMUST00000193950.6 Ighv1-37 (from geneSymbol) A0A0A6YW32 A0A0A6YW32_MOUSE ENSMUST00000193950.1 ENSMUST00000193950.2 ENSMUST00000193950.3 ENSMUST00000193950.4 ENSMUST00000193950.5 Ighv1-37 uc288jzf.1 uc288jzf.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jzf.1 uc288jzf.2 
ENSMUST00000193951.2 Gm37299 ENSMUST00000193951.2 Gm37299 (from geneSymbol) ENSMUST00000193951.1 uc287prc.1 uc287prc.2 uc287prc.1 uc287prc.2 
ENSMUST00000193956.2 Gm10862 ENSMUST00000193956.2 Gm10862 (from geneSymbol) AK162393 ENSMUST00000193956.1 uc289srh.1 uc289srh.2 uc289srh.1 uc289srh.2 
ENSMUST00000193958.2 Gm37788 ENSMUST00000193958.2 Gm37788 (from geneSymbol) AK086196 ENSMUST00000193958.1 uc287mww.1 uc287mww.2 uc287mww.1 uc287mww.2 
ENSMUST00000193960.2 1600017P15Rik ENSMUST00000193960.2 1600017P15Rik (from geneSymbol) ENSMUST00000193960.1 uc290ehi.1 uc290ehi.2 uc290ehi.1 uc290ehi.2 
ENSMUST00000193962.2 4933417C20Rik ENSMUST00000193962.2 4933417C20Rik (from geneSymbol) AK016840 ENSMUST00000193962.1 uc287mzq.1 uc287mzq.2 uc287mzq.1 uc287mzq.2 
ENSMUST00000193964.3 Gm37933 ENSMUST00000193964.3 Gm37933 (from geneSymbol) AK080030 ENSMUST00000193964.1 ENSMUST00000193964.2 uc008prd.1 uc008prd.2 uc008prd.3 uc008prd.1 uc008prd.2 uc008prd.3 
ENSMUST00000193965.2 Gm37725 ENSMUST00000193965.2 Gm37725 (from geneSymbol) ENSMUST00000193965.1 uc290fyf.1 uc290fyf.2 uc290fyf.1 uc290fyf.2 
ENSMUST00000193966.2 Gm29678 ENSMUST00000193966.2 predicted gene, 29678 (from RefSeq NR_151624.1) ENSMUST00000193966.1 NR_151624 uc287oxi.1 uc287oxi.2 uc287oxi.1 uc287oxi.2 
ENSMUST00000193968.2 Gm37655 ENSMUST00000193968.2 Gm37655 (from geneSymbol) ENSMUST00000193968.1 uc287mfu.1 uc287mfu.2 uc287mfu.1 uc287mfu.2 
ENSMUST00000193969.2 Gm37347 ENSMUST00000193969.2 Gm37347 (from geneSymbol) ENSMUST00000193969.1 uc287hpm.1 uc287hpm.2 uc287hpm.1 uc287hpm.2 
ENSMUST00000193978.2 5430433H01Rik ENSMUST00000193978.2 5430433H01Rik (from geneSymbol) AK017386 ENSMUST00000193978.1 uc290fdi.1 uc290fdi.2 uc290fdi.1 uc290fdi.2 
ENSMUST00000193983.2 Gm33280 ENSMUST00000193983.2 Gm33280 (from geneSymbol) AK137601 ENSMUST00000193983.1 uc287hgb.1 uc287hgb.2 uc287hgb.1 uc287hgb.2 
ENSMUST00000193984.2 Gm37388 ENSMUST00000193984.2 Gm37388 (from geneSymbol) A0A0A6YY46 A0A0A6YY46_MOUSE BC080863 ENSMUST00000193984.1 Gm37388 uc289oti.1 uc289oti.2 integral component of plasma membrane cell adhesion membrane integral component of membrane uc289oti.1 uc289oti.2 
ENSMUST00000193985.3 Gm36945 ENSMUST00000193985.3 Gm36945 (from geneSymbol) ENSMUST00000193985.1 ENSMUST00000193985.2 uc287njc.1 uc287njc.2 uc287njc.3 uc287njc.1 uc287njc.2 uc287njc.3 
ENSMUST00000193986.2 Gm38337 ENSMUST00000193986.2 Gm38337 (from geneSymbol) ENSMUST00000193986.1 uc289pab.1 uc289pab.2 uc289pab.1 uc289pab.2 
ENSMUST00000193989.4 Wdr49 ENSMUST00000193989.4 WD repeat domain 49 (from RefSeq NM_001370850.1) A0A0N4SUK7 A0A0N4SUK7_MOUSE ENSMUST00000193989.1 ENSMUST00000193989.2 ENSMUST00000193989.3 NM_001370850 Wdr49 uc290fyt.1 uc290fyt.2 molecular_function cellular_component biological_process uc290fyt.1 uc290fyt.2 
ENSMUST00000193990.2 Gm38063 ENSMUST00000193990.2 Gm38063 (from geneSymbol) ENSMUST00000193990.1 uc287rsx.1 uc287rsx.2 uc287rsx.1 uc287rsx.2 
ENSMUST00000193993.2 Gm37573 ENSMUST00000193993.2 Gm37573 (from geneSymbol) BC005523 ENSMUST00000193993.1 uc290edp.1 uc290edp.2 uc290edp.1 uc290edp.2 
ENSMUST00000193995.2 Gm37735 ENSMUST00000193995.2 Gm37735 (from geneSymbol) AK085475 ENSMUST00000193995.1 uc287iyq.1 uc287iyq.2 uc287iyq.1 uc287iyq.2 
ENSMUST00000193996.6 Gm38371 ENSMUST00000193996.6 Gm38371 (from geneSymbol) ENSMUST00000193996.1 ENSMUST00000193996.2 ENSMUST00000193996.3 ENSMUST00000193996.4 ENSMUST00000193996.5 uc292snw.1 uc292snw.2 uc292snw.1 uc292snw.2 
ENSMUST00000193997.6 Trbv23 ENSMUST00000193997.6 Trbv23 (from geneSymbol) A0A0A6YWQ1 A0A0A6YWQ1_MOUSE ENSMUST00000193997.1 ENSMUST00000193997.2 ENSMUST00000193997.3 ENSMUST00000193997.4 ENSMUST00000193997.5 Trbv23 uc291dus.1 uc291dus.2 uc291dus.1 uc291dus.2 
ENSMUST00000193999.2 4930590H14Rik ENSMUST00000193999.2 4930590H14Rik (from geneSymbol) AK016379 ENSMUST00000193999.1 uc292iyg.1 uc292iyg.2 uc292iyg.1 uc292iyg.2 
ENSMUST00000194000.2 Gm36972 ENSMUST00000194000.2 Gm36972 (from geneSymbol) ENSMUST00000194000.1 uc287nlk.1 uc287nlk.2 uc287nlk.1 uc287nlk.2 
ENSMUST00000194001.2 Gm38225 ENSMUST00000194001.2 Gm38225 (from geneSymbol) ENSMUST00000194001.1 uc289otb.1 uc289otb.2 uc289otb.1 uc289otb.2 
ENSMUST00000194002.3 4930448I06Rik ENSMUST00000194002.3 RIKEN cDNA 4930448I06 gene (from RefSeq NR_040475.1) ENSMUST00000194002.1 ENSMUST00000194002.2 NR_040475 uc029qny.1 uc029qny.2 uc029qny.3 uc029qny.4 uc029qny.1 uc029qny.2 uc029qny.3 uc029qny.4 
ENSMUST00000194004.2 Gm37517 ENSMUST00000194004.2 Gm37517 (from geneSymbol) AK080406 ENSMUST00000194004.1 uc287jty.1 uc287jty.2 uc287jty.1 uc287jty.2 
ENSMUST00000194005.2 Gm37373 ENSMUST00000194005.2 Gm37373 (from geneSymbol) AK156006 ENSMUST00000194005.1 uc287igt.1 uc287igt.2 uc287igt.1 uc287igt.2 
ENSMUST00000194009.2 5830444F18Rik ENSMUST00000194009.2 5830444F18Rik (from geneSymbol) AK037279 ENSMUST00000194009.1 uc289lvx.1 uc289lvx.2 uc289lvx.1 uc289lvx.2 
ENSMUST00000194016.6 Pex5l ENSMUST00000194016.6 Belongs to the peroxisomal targeting signal receptor family. (from UniProt F8SLQ1) ENSMUST00000194016.1 ENSMUST00000194016.2 ENSMUST00000194016.3 ENSMUST00000194016.4 ENSMUST00000194016.5 F8SLQ1 F8SLQ1_MOUSE HQ646191 Pex5l uc029ukr.1 uc029ukr.2 uc029ukr.3 uc029ukr.4 uc029ukr.5 Belongs to the peroxisomal targeting signal receptor family. peroxisome targeting sequence binding small GTPase binding receptor complex uc029ukr.1 uc029ukr.2 uc029ukr.3 uc029ukr.4 uc029ukr.5 
ENSMUST00000194017.2 Gm37217 ENSMUST00000194017.2 Gm37217 (from geneSymbol) AK172631 ENSMUST00000194017.1 uc287jas.1 uc287jas.2 uc287jas.1 uc287jas.2 
ENSMUST00000194018.2 Gm37799 ENSMUST00000194018.2 Gm37799 (from geneSymbol) ENSMUST00000194018.1 uc287mcw.1 uc287mcw.2 uc287mcw.1 uc287mcw.2 
ENSMUST00000194021.2 Gm37820 ENSMUST00000194021.2 Gm37820 (from geneSymbol) ENSMUST00000194021.1 uc288vbg.1 uc288vbg.2 uc288vbg.1 uc288vbg.2 
ENSMUST00000194030.3 Gm38326 ENSMUST00000194030.3 Gm38326 (from geneSymbol) AK136176 ENSMUST00000194030.1 ENSMUST00000194030.2 uc290fom.1 uc290fom.2 uc290fom.3 uc290fom.1 uc290fom.2 uc290fom.3 
ENSMUST00000194032.2 Gm38064 ENSMUST00000194032.2 Gm38064 (from geneSymbol) ENSMUST00000194032.1 uc287ovo.1 uc287ovo.2 uc287ovo.1 uc287ovo.2 
ENSMUST00000194038.2 Pcdha8 ENSMUST00000194038.2 protocadherin alpha 8 (from RefSeq NM_201243.1) ENSMUST00000194038.1 NM_201243 Pcdha1 Pcdha8 Q91Y12 Q91Y12_MOUSE uc008epd.1 uc008epd.2 uc008epd.3 uc008epd.4 uc008epd.5 Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008epd.1 uc008epd.2 uc008epd.3 uc008epd.4 uc008epd.5 
ENSMUST00000194040.3 1700029B24Rik ENSMUST00000194040.3 1700029B24Rik (from geneSymbol) AK006483 ENSMUST00000194040.1 ENSMUST00000194040.2 uc290dvl.1 uc290dvl.2 uc290dvl.1 uc290dvl.2 
ENSMUST00000194043.6 Gm37572 ENSMUST00000194043.6 Gm37572 (from geneSymbol) ENSMUST00000194043.1 ENSMUST00000194043.2 ENSMUST00000194043.3 ENSMUST00000194043.4 ENSMUST00000194043.5 uc292siu.1 uc292siu.2 uc292siu.1 uc292siu.2 
ENSMUST00000194044.6 Gm28040 ENSMUST00000194044.6 Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Intracerebroventricular administration induces an increase in serum LH and FSH levels in prepubertal male and female as well as in adult animals. (from UniProt Q6Y4S4) AY707860 ENSMUST00000194044.1 ENSMUST00000194044.2 ENSMUST00000194044.3 ENSMUST00000194044.4 ENSMUST00000194044.5 KISS1_MOUSE Kiss1 Q149Z8 Q68Y93 Q6Y4S4 Q80XF6 uc011wrz.1 uc011wrz.2 uc011wrz.3 Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Intracerebroventricular administration induces an increase in serum LH and FSH levels in prepubertal male and female as well as in adult animals. Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6Y4S4-1; Sequence=Displayed; Name=2; IsoId=Q6Y4S4-2; Sequence=VSP_012957; Weak in all tissue types with highest levels in lung and 15- 17-day embryos. Expressed in areas of the hypothalamus implicated in the neuroendocrine regulation of gonadotropin secretion, including the anteroventral periventricular nucleus, the periventricular nucleus, and the arcuate nucleus. Animals are viable and healthy with no apparent abnormalities but fail to undergo sexual maturation. Mutant female do not progress through the estrous cycle, have thread-like uteri and small ovaries, and do not produce mature Graffian follicles. Mutant males have small testes, and spermatogenesis arrested mainly at the early haploid spermatid stage. Both sexes have low circulating gonadotropin (LH and FSH) and sex steroid (beta-estradiol or testosterone) hormone levels. Migration of GnRH neurons into the hypothalamus appears normal with appropriate axonal connections to the median eminence and total GnRH content. The hypothalamic-pituitary axis is functional, as shown by robust LH secretion after peripheral administration of kisspeptin. Belongs to the KISS1 family. Sequence=AAO64981.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; extracellular region extracellular space cytoplasm G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration negative regulation of cell proliferation apical plasma membrane kisspeptin receptor binding positive regulation of luteinizing hormone secretion neuron projection neuronal cell body positive regulation of MAPK cascade decidualization positive regulation of synaptic transmission positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway generation of ovulation cycle rhythm positive regulation of growth hormone secretion uc011wrz.1 uc011wrz.2 uc011wrz.3 
ENSMUST00000194052.2 Gm37277 ENSMUST00000194052.2 Gm37277 (from geneSymbol) ENSMUST00000194052.1 uc287gfa.1 uc287gfa.2 uc287gfa.1 uc287gfa.2 
ENSMUST00000194053.2 Gm37943 ENSMUST00000194053.2 Gm37943 (from geneSymbol) ENSMUST00000194053.1 uc287mwh.1 uc287mwh.2 uc287mwh.1 uc287mwh.2 
ENSMUST00000194055.2 Gm37458 ENSMUST00000194055.2 Gm37458 (from geneSymbol) ENSMUST00000194055.1 uc289fdw.1 uc289fdw.2 uc289fdw.1 uc289fdw.2 
ENSMUST00000194058.2 Gm38253 ENSMUST00000194058.2 Gm38253 (from geneSymbol) AK141379 ENSMUST00000194058.1 uc290inu.1 uc290inu.2 uc290inu.1 uc290inu.2 
ENSMUST00000194059.2 Snurf ENSMUST00000194059.2 SNRPN upstream reading frame (from RefSeq NM_033174.4) ENSMUST00000194059.1 NM_033174 Q924D8 Q9WU12 SNURF_MOUSE uc291qvx.1 uc291qvx.2 This gene is located within the mouse orthologous Prader-Willi Syndrome critical region and is imprinted and expressed from the paternal allele. This transcipt is thought to be bicistronic and can encode the small nuclear ribonucleoprotein polypeptide N (Snrpn) from a downstream open reading frame. The small protein represented by this gene is encoded by an evolutionarily-conserved upstream open reading frame and is localized to the nucleus. [provided by RefSeq, Mar 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.105967.1, SRR1660817.202313.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164141 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## bicistronic transcript :: PMID: 10318933 imprinted gene :: PMID: 11431693 NMD candidate :: PMID: 10318933 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Nucleus Expressed in brain and embryonic stem (ES) cells (at protein level). Expressed in the brain, ovary, testis, liver, heart, kidney and muscle. Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF. Only the primary 1.6-kb bicistronic SNURF- SNRPN transcript is detected. Belongs to the SNURF family. nucleus nuclear speck ATPase binding uc291qvx.1 uc291qvx.2 
ENSMUST00000194060.6 Gm34716 ENSMUST00000194060.6 Gm34716 (from geneSymbol) ENSMUST00000194060.1 ENSMUST00000194060.2 ENSMUST00000194060.3 ENSMUST00000194060.4 ENSMUST00000194060.5 uc292sll.1 uc292sll.2 uc292sll.1 uc292sll.2 
ENSMUST00000194067.2 Gm38279 ENSMUST00000194067.2 Gm38279 (from geneSymbol) AB349435 ENSMUST00000194067.1 uc292jfj.1 uc292jfj.2 uc292jfj.1 uc292jfj.2 
ENSMUST00000194071.2 Ighv1-56 ENSMUST00000194071.2 Ighv1-56 (from geneSymbol) A0A0A6YXG2 A0A0A6YXG2_MOUSE AK007918 ENSMUST00000194071.1 Ighv1-56 uc288kam.1 uc288kam.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kam.1 uc288kam.2 
ENSMUST00000194072.2 Gm21809 ENSMUST00000194072.2 Gm21809 (from geneSymbol) ENSMUST00000194072.1 uc292sjv.1 uc292sjv.2 uc292sjv.1 uc292sjv.2 
ENSMUST00000194074.2 Gm38322 ENSMUST00000194074.2 Gm38322 (from geneSymbol) AK156228 ENSMUST00000194074.1 uc287pdr.1 uc287pdr.2 uc287pdr.1 uc287pdr.2 
ENSMUST00000194078.2 2610034O05Rik ENSMUST00000194078.2 2610034O05Rik (from geneSymbol) ENSMUST00000194078.1 uc287tam.1 uc287tam.2 uc287tam.1 uc287tam.2 
ENSMUST00000194081.2 Gm38212 ENSMUST00000194081.2 Gm38212 (from geneSymbol) ENSMUST00000194081.1 uc287kyr.1 uc287kyr.2 uc287kyr.1 uc287kyr.2 
ENSMUST00000194086.2 Gm35134 ENSMUST00000194086.2 Belongs to the XLR/SYCP3 family. (from UniProt A0A087WRL2) A0A087WRL2 A0A087WRL2_MOUSE ENSMUST00000194086.1 Gm21865 Gm30737 Gm35134 uc292slq.1 uc292slq.2 Belongs to the XLR/SYCP3 family. synaptonemal complex spermatogenesis spermatid development meiotic cell cycle uc292slq.1 uc292slq.2 
ENSMUST00000194090.2 Gm36988 ENSMUST00000194090.2 Gm36988 (from geneSymbol) ENSMUST00000194090.1 uc289srt.1 uc289srt.2 uc289srt.1 uc289srt.2 
ENSMUST00000194091.6 Agrp ENSMUST00000194091.6 Secreted (from UniProt Q3UU47) AK138796 Agrp ENSMUST00000194091.1 ENSMUST00000194091.2 ENSMUST00000194091.3 ENSMUST00000194091.4 ENSMUST00000194091.5 Q3UU47 Q3UU47_MOUSE uc009ndi.1 uc009ndi.2 uc009ndi.3 uc009ndi.4 Secreted Lacks conserved residue(s) required for the propagation of feature annotation. receptor binding neuropeptide hormone activity extracellular region extracellular space Golgi lumen neuropeptide signaling pathway circadian rhythm adult feeding behavior hormone-mediated signaling pathway response to insulin eating behavior neuronal cell body long-day photoperiodism maternal process involved in female pregnancy regulation of feeding behavior positive regulation of feeding behavior uc009ndi.1 uc009ndi.2 uc009ndi.3 uc009ndi.4 
ENSMUST00000194093.2 Gm38142 ENSMUST00000194093.2 Gm38142 (from geneSymbol) ENSMUST00000194093.1 uc287kbi.1 uc287kbi.2 uc287kbi.1 uc287kbi.2 
ENSMUST00000194096.2 Gm37549 ENSMUST00000194096.2 Gm37549 (from geneSymbol) ENSMUST00000194096.1 uc289nes.1 uc289nes.2 uc289nes.1 uc289nes.2 
ENSMUST00000194097.2 Gm10730 ENSMUST00000194097.2 Gm10730 (from geneSymbol) ENSMUST00000194097.1 uc290faf.1 uc290faf.2 uc290faf.1 uc290faf.2 
ENSMUST00000194099.2 Gm37686 ENSMUST00000194099.2 Gm37686 (from geneSymbol) AK051499 ENSMUST00000194099.1 uc287gdh.1 uc287gdh.2 uc287gdh.1 uc287gdh.2 
ENSMUST00000194102.6 Fcrl5 ENSMUST00000194102.6 Fc receptor-like 5, transcript variant 1 (from RefSeq NM_183222.3) E9QLI5 ENSMUST00000194102.1 ENSMUST00000194102.2 ENSMUST00000194102.3 ENSMUST00000194102.4 ENSMUST00000194102.5 FCRL5_MOUSE Fcrh3 NM_183222 Q68SN8 Q80WN2 Q8BJA5 uc012crg.1 uc012crg.2 uc012crg.3 May play a role in fertilization. Interacts with PTPN6, PTPN11, SYK and ZAP70. Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q68SN8-1; Sequence=Displayed; Name=2; IsoId=Q68SN8-2; Sequence=VSP_033309; Preferentially expressed in marginal zone B cells. Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases. Mating of knockout (KO) female and wild-type (WT) male results in 30% KO/WT pairs without fertilization output. It is uncertain whether Met-1 or Met-14 is the initiator. Sequence=AAO20873.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; protein binding plasma membrane cell surface membrane integral component of membrane receptor complex negative regulation of B cell receptor signaling pathway negative regulation of release of sequestered calcium ion into cytosol uc012crg.1 uc012crg.2 uc012crg.3 
ENSMUST00000194104.4 4833445I07Rik ENSMUST00000194104.4 4833445I07Rik (from geneSymbol) ENSMUST00000194104.1 ENSMUST00000194104.2 ENSMUST00000194104.3 uc292lhb.1 uc292lhb.2 uc292lhb.3 uc292lhb.4 uc292lhb.1 uc292lhb.2 uc292lhb.3 uc292lhb.4 
ENSMUST00000194105.2 Gm36975 ENSMUST00000194105.2 Gm36975 (from geneSymbol) AK053130 ENSMUST00000194105.1 uc287mzz.1 uc287mzz.2 uc287mzz.1 uc287mzz.2 
ENSMUST00000194107.2 Gm38106 ENSMUST00000194107.2 Gm38106 (from geneSymbol) ENSMUST00000194107.1 uc287jcd.1 uc287jcd.2 uc287jcd.1 uc287jcd.2 
ENSMUST00000194109.2 Gm37209 ENSMUST00000194109.2 Gm37209 (from geneSymbol) AK157003 ENSMUST00000194109.1 uc290fbq.1 uc290fbq.2 uc290fbq.1 uc290fbq.2 
ENSMUST00000194110.2 Gm37666 ENSMUST00000194110.2 Gm37666 (from geneSymbol) AK078426 ENSMUST00000194110.1 uc289wqc.1 uc289wqc.2 uc289wqc.1 uc289wqc.2 
ENSMUST00000194112.2 Gm38163 ENSMUST00000194112.2 Gm38163 (from geneSymbol) ENSMUST00000194112.1 uc292lhr.1 uc292lhr.2 uc292lhr.1 uc292lhr.2 
ENSMUST00000194114.2 Gm37079 ENSMUST00000194114.2 Gm37079 (from geneSymbol) AK030765 ENSMUST00000194114.1 uc287gff.1 uc287gff.2 uc287gff.1 uc287gff.2 
ENSMUST00000194117.2 Gm37780 ENSMUST00000194117.2 Gm37780 (from geneSymbol) AK033742 ENSMUST00000194117.1 uc289tdv.1 uc289tdv.2 uc289tdv.1 uc289tdv.2 
ENSMUST00000194120.2 Gm37775 ENSMUST00000194120.2 Gm37775 (from geneSymbol) ENSMUST00000194120.1 uc287mko.1 uc287mko.2 uc287mko.1 uc287mko.2 
ENSMUST00000194121.2 Gm38146 ENSMUST00000194121.2 Gm38146 (from geneSymbol) ENSMUST00000194121.1 LF204561 uc287ofu.1 uc287ofu.2 uc287ofu.1 uc287ofu.2 
ENSMUST00000194123.2 Gm10766 ENSMUST00000194123.2 Gm10766 (from geneSymbol) ENSMUST00000194123.1 LF193560 uc290aft.1 uc290aft.2 uc290aft.1 uc290aft.2 
ENSMUST00000194130.2 Gm37937 ENSMUST00000194130.2 Gm37937 (from geneSymbol) ENSMUST00000194130.1 uc292skj.1 uc292skj.2 uc292skj.1 uc292skj.2 
ENSMUST00000194131.2 Gm38383 ENSMUST00000194131.2 Gm38383 (from geneSymbol) AB353027 ENSMUST00000194131.1 uc289tqo.1 uc289tqo.2 uc289tqo.1 uc289tqo.2 
ENSMUST00000194134.6 Mme ENSMUST00000194134.6 membrane metallo endopeptidase, transcript variant 2 (from RefSeq NM_008604.4) ENSMUST00000194134.1 ENSMUST00000194134.2 ENSMUST00000194134.3 ENSMUST00000194134.4 ENSMUST00000194134.5 Mme NEP_MOUSE NM_008604 Q61391 Q6NXX5 Q8K251 uc008pjq.1 uc008pjq.2 uc008pjq.3 uc008pjq.4 Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (By similarity). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (By similarity). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (By similarity). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (By similarity). Involved in the degradation of the atrial natriuretic factor (ANF) (By similarity). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). Reaction=Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.; EC=3.4.24.11; Evidence=; Reaction=H2O + substance P = L-Leu-L-Met-NH2 + substance P(1-9); Xref=Rhea:RHEA:71459, ChEBI:CHEBI:15377, ChEBI:CHEBI:190692, ChEBI:CHEBI:190693, ChEBI:CHEBI:190700; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71460; Evidence=; Reaction=H2O + substance P = L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1- 7); Xref=Rhea:RHEA:71467, ChEBI:CHEBI:15377, ChEBI:CHEBI:190692, ChEBI:CHEBI:190695, ChEBI:CHEBI:190698; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71468; Evidence=; Reaction=H2O + neurotensin = L-isoleucyl-L-leucine + neurotensin(1-11); Xref=Rhea:RHEA:71475, ChEBI:CHEBI:15377, ChEBI:CHEBI:147362, ChEBI:CHEBI:190704, ChEBI:CHEBI:190706; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71476; Evidence=; Reaction=H2O + neurotensin = L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10); Xref=Rhea:RHEA:71479, ChEBI:CHEBI:15377, ChEBI:CHEBI:147362, ChEBI:CHEBI:190705, ChEBI:CHEBI:190707; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71480; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Cell membrane ; Single-pass type II membrane protein Myristoylation is a determinant of membrane targeting. Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity. Mice are overtly normal in appearance and size and do not show obvious abnormalities in motor performance or coordination. Nerve conduction studies reveal no significant differences between mutant and control animals. Belongs to the peptidase M13 family. phosphatidylserine binding kidney development placenta development endopeptidase activity metalloendopeptidase activity cytoplasm early endosome trans-Golgi network plasma membrane brush border proteolysis peptide metabolic process aging learning or memory synaptic vesicle peptidase activity metallopeptidase activity exopeptidase activity zinc ion binding membrane integral component of membrane hydrolase activity sensory perception of pain lung development axon dendrite cytoplasmic vesicle peptide binding protein homodimerization activity neuronal cell body neuron projection terminus membrane raft synapse creatinine metabolic process metal ion binding beta-amyloid metabolic process positive regulation of neurogenesis oligopeptidase activity cellular response to cytokine stimulus cellular response to UV-A cellular response to UV-B replicative senescence beta-amyloid clearance presynapse positive regulation of long-term synaptic potentiation cardiolipin binding uc008pjq.1 uc008pjq.2 uc008pjq.3 uc008pjq.4 
ENSMUST00000194135.2 Gm37553 ENSMUST00000194135.2 Gm37553 (from geneSymbol) AK051940 ENSMUST00000194135.1 uc292kaz.1 uc292kaz.2 uc292kaz.1 uc292kaz.2 
ENSMUST00000194136.2 Gm38125 ENSMUST00000194136.2 Gm38125 (from geneSymbol) AK083553 ENSMUST00000194136.1 uc287ina.1 uc287ina.2 uc287ina.1 uc287ina.2 
ENSMUST00000194137.2 Gm21955 ENSMUST00000194137.2 Gm21955 (from geneSymbol) ENSMUST00000194137.1 uc290max.1 uc290max.2 uc290max.1 uc290max.2 
ENSMUST00000194140.3 4930447F24Rik ENSMUST00000194140.3 RIKEN cDNA 4930447F24 gene, transcript variant 1 (from RefSeq NR_126077.1) ENSMUST00000194140.1 ENSMUST00000194140.2 NR_126077 uc009row.1 uc009row.2 uc009row.3 uc009row.4 uc009row.1 uc009row.2 uc009row.3 uc009row.4 
ENSMUST00000194141.2 Gm37773 ENSMUST00000194141.2 Gm37773 (from geneSymbol) AK049947 ENSMUST00000194141.1 uc290jce.1 uc290jce.2 uc290jce.1 uc290jce.2 
ENSMUST00000194145.6 Gm38159 ENSMUST00000194145.6 Gm38159 (from geneSymbol) ENSMUST00000194145.1 ENSMUST00000194145.2 ENSMUST00000194145.3 ENSMUST00000194145.4 ENSMUST00000194145.5 uc292shf.1 uc292shf.2 uc292shf.1 uc292shf.2 
ENSMUST00000194146.2 A930036K24Rik ENSMUST00000194146.2 A930036K24Rik (from geneSymbol) AK044545 ENSMUST00000194146.1 uc292kxd.1 uc292kxd.2 uc292kxd.1 uc292kxd.2 
ENSMUST00000194151.2 Gm37510 ENSMUST00000194151.2 Gm37510 (from geneSymbol) AK155614 ENSMUST00000194151.1 uc287ljh.1 uc287ljh.2 uc287ljh.1 uc287ljh.2 
ENSMUST00000194155.2 Gm37759 ENSMUST00000194155.2 Gm37759 (from geneSymbol) BC027122 ENSMUST00000194155.1 uc287mbq.1 uc287mbq.2 uc287mbq.1 uc287mbq.2 
ENSMUST00000194159.2 Ighv9-4 ENSMUST00000194159.2 Ighv9-4 (from geneSymbol) A0A0A6YWH6 A0A0A6YWH6_MOUSE AF045485 ENSMUST00000194159.1 Ighv9-4 uc288jwk.1 uc288jwk.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jwk.1 uc288jwk.2 
ENSMUST00000194161.2 4930474B08Rik ENSMUST00000194161.2 4930474B08Rik (from geneSymbol) AK015571 ENSMUST00000194161.1 uc287kio.1 uc287kio.2 uc287kio.1 uc287kio.2 
ENSMUST00000194162.6 Ighd ENSMUST00000194162.6 Ighd (from geneSymbol) A0A0A6YW14 A0A0A6YW14_MOUSE BC037128 ENSMUST00000194162.1 ENSMUST00000194162.2 ENSMUST00000194162.3 ENSMUST00000194162.4 ENSMUST00000194162.5 Ighd uc288jrt.1 uc288jrt.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane membrane integral component of membrane immunoglobulin mediated immune response somatic hypermutation of immunoglobulin genes B cell receptor complex positive regulation of B cell proliferation immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response regulation of immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jrt.1 uc288jrt.2 
ENSMUST00000194169.2 Gm37479 ENSMUST00000194169.2 Gm37479 (from geneSymbol) ENSMUST00000194169.1 uc287lmf.1 uc287lmf.2 uc287lmf.1 uc287lmf.2 
ENSMUST00000194174.2 Gm37889 ENSMUST00000194174.2 Gm37889 (from geneSymbol) ENSMUST00000194174.1 uc290ecz.1 uc290ecz.2 uc290ecz.1 uc290ecz.2 
ENSMUST00000194177.2 Gm37674 ENSMUST00000194177.2 Gm37674 (from geneSymbol) AK039143 ENSMUST00000194177.1 uc287pdw.1 uc287pdw.2 uc287pdw.1 uc287pdw.2 
ENSMUST00000194178.2 Gm38157 ENSMUST00000194178.2 Gm38157 (from geneSymbol) ENSMUST00000194178.1 uc287hcz.1 uc287hcz.2 uc287hcz.1 uc287hcz.2 
ENSMUST00000194180.2 Gm37411 ENSMUST00000194180.2 Gm37411 (from geneSymbol) ENSMUST00000194180.1 LF192970 uc287niq.1 uc287niq.2 uc287niq.1 uc287niq.2 
ENSMUST00000194190.2 Pcdhga1 ENSMUST00000194190.2 protocadherin gamma subfamily A, 1 (from RefSeq NM_033584.2) ENSMUST00000194190.1 NM_033584 Pcdhga1 Q91XZ0 Q91XZ0_MOUSE uc008eql.1 uc008eql.2 uc008eql.3 uc008eql.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding protein binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane metal ion binding uc008eql.1 uc008eql.2 uc008eql.3 uc008eql.4 
ENSMUST00000194198.3 Gm30292 ENSMUST00000194198.3 predicted gene, 30292 (from RefSeq NR_166453.1) ENSMUST00000194198.1 ENSMUST00000194198.2 NR_166453 uc290feu.1 uc290feu.2 uc290feu.3 uc290feu.1 uc290feu.2 uc290feu.3 
ENSMUST00000194200.2 Gm36974 ENSMUST00000194200.2 Gm36974 (from geneSymbol) ENSMUST00000194200.1 uc292frp.1 uc292frp.2 uc292frp.1 uc292frp.2 
ENSMUST00000194202.2 Gm37303 ENSMUST00000194202.2 Gm37303 (from geneSymbol) AK153852 ENSMUST00000194202.1 uc292ipw.1 uc292ipw.2 uc292ipw.1 uc292ipw.2 
ENSMUST00000194203.2 Gm10513 ENSMUST00000194203.2 Gm10513 (from geneSymbol) AK149677 ENSMUST00000194203.1 uc289gzb.1 uc289gzb.2 uc289gzb.1 uc289gzb.2 
ENSMUST00000194205.2 Gm37349 ENSMUST00000194205.2 Gm37349 (from geneSymbol) ENSMUST00000194205.1 LF193098 uc287ozt.1 uc287ozt.2 uc287ozt.1 uc287ozt.2 
ENSMUST00000194208.6 Cd1d2 ENSMUST00000194208.6 Cd1d2 (from geneSymbol) ENSMUST00000194208.1 ENSMUST00000194208.2 ENSMUST00000194208.3 ENSMUST00000194208.4 ENSMUST00000194208.5 M63697 uc029umx.1 uc029umx.2 uc029umx.3 uc029umx.4 uc029umx.1 uc029umx.2 uc029umx.3 uc029umx.4 
ENSMUST00000194210.2 Gm37630 ENSMUST00000194210.2 Gm37630 (from geneSymbol) AK042825 ENSMUST00000194210.1 uc287mkk.1 uc287mkk.2 uc287mkk.1 uc287mkk.2 
ENSMUST00000194215.2 E430014B02Rik ENSMUST00000194215.2 E430014B02Rik (from geneSymbol) AK134165 ENSMUST00000194215.1 uc008czh.1 uc008czh.2 uc008czh.1 uc008czh.2 
ENSMUST00000194216.2 Gm37795 ENSMUST00000194216.2 Gm37795 (from geneSymbol) ENSMUST00000194216.1 FV526190 uc290rzx.1 uc290rzx.2 uc290rzx.1 uc290rzx.2 
ENSMUST00000194221.2 Gm37779 ENSMUST00000194221.2 Gm37779 (from geneSymbol) AB338849 ENSMUST00000194221.1 uc287kws.1 uc287kws.2 uc287kws.1 uc287kws.2 
ENSMUST00000194223.2 Gm37696 ENSMUST00000194223.2 Gm37696 (from geneSymbol) AK089331 ENSMUST00000194223.1 uc056zsp.1 uc056zsp.2 uc056zsp.3 uc056zsp.4 uc056zsp.5 uc056zsp.1 uc056zsp.2 uc056zsp.3 uc056zsp.4 uc056zsp.5 
ENSMUST00000194229.3 Or6y1 ENSMUST00000194229.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q050) E9Q050 E9Q050_MOUSE ENSMUST00000194229.1 ENSMUST00000194229.2 Olfr220 Or6y1 uc287ocq.1 uc287ocq.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ocq.1 uc287ocq.2 
ENSMUST00000194238.2 Gm37117 ENSMUST00000194238.2 Gm37117 (from geneSymbol) ENSMUST00000194238.1 uc290oab.1 uc290oab.2 uc290oab.1 uc290oab.2 
ENSMUST00000194239.6 Gm37434 ENSMUST00000194239.6 Gm37434 (from geneSymbol) ENSMUST00000194239.1 ENSMUST00000194239.2 ENSMUST00000194239.3 ENSMUST00000194239.4 ENSMUST00000194239.5 uc292sqc.1 uc292sqc.2 uc292sqc.1 uc292sqc.2 
ENSMUST00000194243.2 Gm37940 ENSMUST00000194243.2 Gm37940 (from geneSymbol) ENSMUST00000194243.1 LF195361 uc291czr.1 uc291czr.2 uc291czr.1 uc291czr.2 
ENSMUST00000194245.2 Gm38300 ENSMUST00000194245.2 Gm38300 (from geneSymbol) BC026815 ENSMUST00000194245.1 uc287ohh.1 uc287ohh.2 uc287ohh.1 uc287ohh.2 
ENSMUST00000194246.2 Gm37423 ENSMUST00000194246.2 Gm37423 (from geneSymbol) ENSMUST00000194246.1 LF192901 uc287mfo.1 uc287mfo.2 uc287mfo.1 uc287mfo.2 
ENSMUST00000194247.2 Gm38195 ENSMUST00000194247.2 Gm38195 (from geneSymbol) ENSMUST00000194247.1 uc290gad.1 uc290gad.2 uc290gad.1 uc290gad.2 
ENSMUST00000194248.2 Hyi ENSMUST00000194248.2 Hyi (from geneSymbol) BC024619 ENSMUST00000194248.1 uc057ljy.1 uc057ljy.2 uc057ljy.3 uc057ljy.1 uc057ljy.2 uc057ljy.3 
ENSMUST00000194249.2 F830112A20Rik ENSMUST00000194249.2 F830112A20Rik (from geneSymbol) ENSMUST00000194249.1 LF192626 uc287hjq.1 uc287hjq.2 uc287hjq.1 uc287hjq.2 
ENSMUST00000194255.2 Gm36401 ENSMUST00000194255.2 Gm36401 (from geneSymbol) AK076240 ENSMUST00000194255.1 uc290vhr.1 uc290vhr.2 uc290vhr.1 uc290vhr.2 
ENSMUST00000194257.2 Ighv8-5 ENSMUST00000194257.2 Ighv8-5 (from geneSymbol) A0A0A6YY60 A0A0A6YY60_MOUSE AJ421677 ENSMUST00000194257.1 Ighv8-5 uc288jzz.1 uc288jzz.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jzz.1 uc288jzz.2 
ENSMUST00000194261.3 1110002O04Rik ENSMUST00000194261.3 1110002O04Rik (from geneSymbol) AK003327 ENSMUST00000194261.1 ENSMUST00000194261.2 uc007apm.1 uc007apm.2 uc007apm.3 uc007apm.1 uc007apm.2 uc007apm.3 
ENSMUST00000194264.2 Gm37574 ENSMUST00000194264.2 Gm37574 (from geneSymbol) ENSMUST00000194264.1 uc292sph.1 uc292sph.2 uc292sph.1 uc292sph.2 
ENSMUST00000194268.6 Gm32181 ENSMUST00000194268.6 Gm32181 (from geneSymbol) ENSMUST00000194268.1 ENSMUST00000194268.2 ENSMUST00000194268.3 ENSMUST00000194268.4 ENSMUST00000194268.5 uc292ssc.1 uc292ssc.2 uc292ssc.1 uc292ssc.2 
ENSMUST00000194270.2 Gm10253 ENSMUST00000194270.2 Gm10253 (from geneSymbol) AK089708 ENSMUST00000194270.1 uc290gqz.1 uc290gqz.2 uc290gqz.1 uc290gqz.2 
ENSMUST00000194273.2 Gm38289 ENSMUST00000194273.2 Gm38289 (from geneSymbol) ENSMUST00000194273.1 uc287vfi.1 uc287vfi.2 uc287vfi.1 uc287vfi.2 
ENSMUST00000194274.3 Gm20750 ENSMUST00000194274.3 predicted gene, 20750 (from RefSeq NR_040555.1) ENSMUST00000194274.1 ENSMUST00000194274.2 NR_040555 uc029umb.1 uc029umb.2 uc029umb.3 uc029umb.1 uc029umb.2 uc029umb.3 
ENSMUST00000194275.2 Gm37758 ENSMUST00000194275.2 Gm37758 (from geneSymbol) AB350773 ENSMUST00000194275.1 uc292fol.1 uc292fol.2 uc292fol.1 uc292fol.2 
ENSMUST00000194276.2 Gm37028 ENSMUST00000194276.2 Gm37028 (from geneSymbol) DQ200981 ENSMUST00000194276.1 uc290yza.1 uc290yza.2 uc290yza.1 uc290yza.2 
ENSMUST00000194277.2 Gm37270 ENSMUST00000194277.2 Gm37270 (from geneSymbol) AK190252 ENSMUST00000194277.1 uc290qvv.1 uc290qvv.2 uc290qvv.1 uc290qvv.2 
ENSMUST00000194279.6 Il7 ENSMUST00000194279.6 interleukin 7, transcript variant 1 (from RefSeq NM_008371.5) ENSMUST00000194279.1 ENSMUST00000194279.2 ENSMUST00000194279.3 ENSMUST00000194279.4 ENSMUST00000194279.5 Il7 NM_008371 Q544C8 Q544C8_MOUSE uc008ooi.1 uc008ooi.2 uc008ooi.3 uc008ooi.4 The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B- cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Interacts with IL7R and CSF2RG. Secreted Belongs to the IL-7/IL-9 family. positive regulation of cytokine-mediated signaling pathway cytokine activity cytokine receptor binding interleukin-7 receptor binding extracellular region extracellular space immune response growth factor activity cytokine-mediated signaling pathway positive regulation of chemokine production uc008ooi.1 uc008ooi.2 uc008ooi.3 uc008ooi.4 
ENSMUST00000194281.2 Gm36940 ENSMUST00000194281.2 Gm36940 (from geneSymbol) ENSMUST00000194281.1 uc292hlq.1 uc292hlq.2 uc292hlq.1 uc292hlq.2 
ENSMUST00000194285.2 Gm37645 ENSMUST00000194285.2 Gm37645 (from geneSymbol) AK049853 ENSMUST00000194285.1 uc287jrd.1 uc287jrd.2 uc287jrd.1 uc287jrd.2 
ENSMUST00000194286.2 Gm38315 ENSMUST00000194286.2 Gm38315 (from geneSymbol) AK134701 ENSMUST00000194286.1 uc287ovn.1 uc287ovn.2 uc287ovn.1 uc287ovn.2 
ENSMUST00000194287.2 C130012C08Rik ENSMUST00000194287.2 C130012C08Rik (from geneSymbol) ENSMUST00000194287.1 uc288rlp.1 uc288rlp.2 uc288rlp.1 uc288rlp.2 
ENSMUST00000194289.2 Gm37560 ENSMUST00000194289.2 Gm37560 (from geneSymbol) AK155422 ENSMUST00000194289.1 uc292jmc.1 uc292jmc.2 uc292jmc.1 uc292jmc.2 
ENSMUST00000194293.2 Gm38386 ENSMUST00000194293.2 Gm38386 (from geneSymbol) AK036887 ENSMUST00000194293.1 uc289suw.1 uc289suw.2 uc289suw.1 uc289suw.2 
ENSMUST00000194294.2 Gm37734 ENSMUST00000194294.2 Gm37734 (from geneSymbol) ENSMUST00000194294.1 uc292slc.1 uc292slc.2 uc292slc.1 uc292slc.2 
ENSMUST00000194296.6 Il1rl2 ENSMUST00000194296.6 interleukin 1 receptor-like 2, transcript variant 1 (from RefSeq NM_133193.4) ENSMUST00000194296.1 ENSMUST00000194296.2 ENSMUST00000194296.3 ENSMUST00000194296.4 ENSMUST00000194296.5 ILRL2_MOUSE NM_133193 Q9ERS7 uc007aty.1 uc007aty.2 uc007aty.3 Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36- dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302; Evidence=; Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN. Membrane; Single-pass type I membrane protein. Expressed in bone marrow-derived dendritic cells, splenic CD4(+) T-cells, bone marrow-derived macrophages and bone marrow-derived neutrophils. The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. Complete protection from imiquimodum (IMQ)- induced skin pathology observed in wild-type mice, including hyperkeratosis, acanthosis, neutrophil recruitment, and expansion of IL-17-producing T-cells. Belongs to the interleukin-1 receptor family. immune system process cytokine receptor activity interleukin-1 receptor activity interleukin-1, Type I, activating receptor activity cellular_component inflammatory response signal transduction membrane integral component of membrane cytokine-mediated signaling pathway positive regulation of interleukin-6 production innate immune response positive regulation of T cell differentiation regulation of inflammatory response interleukin-1-mediated signaling pathway uc007aty.1 uc007aty.2 uc007aty.3 
ENSMUST00000194304.6 Ighg1 ENSMUST00000194304.6 Ighg1 (from geneSymbol) A0A0A6YWR2 A0A0A6YWR2_MOUSE AK041235 ENSMUST00000194304.1 ENSMUST00000194304.2 ENSMUST00000194304.3 ENSMUST00000194304.4 ENSMUST00000194304.5 Ighg1 uc288jrl.1 uc288jrl.2 membrane integral component of membrane uc288jrl.1 uc288jrl.2 
ENSMUST00000194308.2 Gm37930 ENSMUST00000194308.2 Gm37930 (from geneSymbol) ENSMUST00000194308.1 uc287izj.1 uc287izj.2 uc287izj.1 uc287izj.2 
ENSMUST00000194311.2 Gm38130 ENSMUST00000194311.2 Gm38130 (from geneSymbol) AK155684 ENSMUST00000194311.1 uc287kgj.1 uc287kgj.2 uc287kgj.1 uc287kgj.2 
ENSMUST00000194316.2 Gm36955 ENSMUST00000194316.2 Gm36955 (from geneSymbol) AK139399 ENSMUST00000194316.1 uc287ido.1 uc287ido.2 uc287ido.1 uc287ido.2 
ENSMUST00000194317.2 Gm38115 ENSMUST00000194317.2 Gm38115 (from geneSymbol) ENSMUST00000194317.1 uc287hjp.1 uc287hjp.2 uc287hjp.1 uc287hjp.2 
ENSMUST00000194318.2 Gm38246 ENSMUST00000194318.2 Gm38246 (from geneSymbol) AB349826 ENSMUST00000194318.1 uc290fbr.1 uc290fbr.2 uc290fbr.1 uc290fbr.2 
ENSMUST00000194322.2 Gm20743 ENSMUST00000194322.2 Gm20743 (from geneSymbol) AK034030 ENSMUST00000194322.1 uc287njf.1 uc287njf.2 uc287njf.1 uc287njf.2 
ENSMUST00000194323.2 Gm38058 ENSMUST00000194323.2 Gm38058 (from geneSymbol) ENSMUST00000194323.1 LF192692 uc287iuj.1 uc287iuj.2 uc287iuj.1 uc287iuj.2 
ENSMUST00000194328.2 Gm37118 ENSMUST00000194328.2 Gm37118 (from geneSymbol) ENSMUST00000194328.1 uc289oue.1 uc289oue.2 uc289oue.1 uc289oue.2 
ENSMUST00000194331.2 2700078F05Rik ENSMUST00000194331.2 2700078F05Rik (from geneSymbol) AK012529 ENSMUST00000194331.1 uc287oop.1 uc287oop.2 uc287oop.1 uc287oop.2 
ENSMUST00000194332.2 Gm37626 ENSMUST00000194332.2 Gm37626 (from geneSymbol) AK141444 ENSMUST00000194332.1 uc287hup.1 uc287hup.2 uc287hup.1 uc287hup.2 
ENSMUST00000194334.2 Gm38238 ENSMUST00000194334.2 Gm38238 (from geneSymbol) AK076936 ENSMUST00000194334.1 uc287moi.1 uc287moi.2 uc287moi.1 uc287moi.2 
ENSMUST00000194336.2 Gm17530 ENSMUST00000194336.2 Gm17530 (from geneSymbol) AK135586 ENSMUST00000194336.1 uc292jit.1 uc292jit.2 uc292jit.1 uc292jit.2 
ENSMUST00000194337.2 Gm37638 ENSMUST00000194337.2 Gm37638 (from geneSymbol) AK081820 ENSMUST00000194337.1 uc287ndz.1 uc287ndz.2 uc287ndz.1 uc287ndz.2 
ENSMUST00000194339.2 A430034D21Rik ENSMUST00000194339.2 A430034D21Rik (from geneSymbol) AK042193 ENSMUST00000194339.1 uc287mch.1 uc287mch.2 uc287mch.1 uc287mch.2 
ENSMUST00000194340.2 9530022L04Rik ENSMUST00000194340.2 9530022L04Rik (from geneSymbol) AK020567 ENSMUST00000194340.1 uc290eih.1 uc290eih.2 uc290eih.1 uc290eih.2 
ENSMUST00000194341.2 Gm10417 ENSMUST00000194341.2 Gm10417 (from geneSymbol) AK149882 ENSMUST00000194341.1 uc290yay.1 uc290yay.2 uc290yay.1 uc290yay.2 
ENSMUST00000194342.2 Gm37833 ENSMUST00000194342.2 Gm37833 (from geneSymbol) ENSMUST00000194342.1 LF308693 uc292jmp.1 uc292jmp.2 uc292jmp.1 uc292jmp.2 
ENSMUST00000194343.2 Gm9884 ENSMUST00000194343.2 Gm9884 (from geneSymbol) AK048705 ENSMUST00000194343.1 uc287gyo.1 uc287gyo.2 uc287gyo.1 uc287gyo.2 
ENSMUST00000194347.2 Gm37315 ENSMUST00000194347.2 Gm37315 (from geneSymbol) AK035208 ENSMUST00000194347.1 uc287gtg.1 uc287gtg.2 uc287gtg.1 uc287gtg.2 
ENSMUST00000194350.6 Ighv1-18 ENSMUST00000194350.6 Ighv1-18 (from geneSymbol) A0A0A6YXN4 A0A0A6YXN4_MOUSE ENSMUST00000194350.1 ENSMUST00000194350.2 ENSMUST00000194350.3 ENSMUST00000194350.4 ENSMUST00000194350.5 Ighv1-18 JF339153 uc288jyd.1 uc288jyd.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jyd.1 uc288jyd.2 
ENSMUST00000194351.2 Gm38379 ENSMUST00000194351.2 Gm38379 (from geneSymbol) AK137567 ENSMUST00000194351.1 uc292dnb.1 uc292dnb.2 uc292dnb.1 uc292dnb.2 
ENSMUST00000194352.2 2900037B21Rik ENSMUST00000194352.2 2900037B21Rik (from geneSymbol) AK019327 ENSMUST00000194352.1 uc291rrf.1 uc291rrf.2 uc291rrf.1 uc291rrf.2 
ENSMUST00000194356.2 Gm37049 ENSMUST00000194356.2 Gm37049 (from geneSymbol) ENSMUST00000194356.1 uc287ngy.1 uc287ngy.2 uc287ngy.1 uc287ngy.2 
ENSMUST00000194357.2 Gm37702 ENSMUST00000194357.2 Gm37702 (from geneSymbol) AK041826 ENSMUST00000194357.1 uc287gok.1 uc287gok.2 uc287gok.1 uc287gok.2 
ENSMUST00000194358.2 Gm38217 ENSMUST00000194358.2 Gm38217 (from geneSymbol) AK048163 ENSMUST00000194358.1 uc292fpc.1 uc292fpc.2 uc292fpc.1 uc292fpc.2 
ENSMUST00000194360.2 Gm37261 ENSMUST00000194360.2 Gm37261 (from geneSymbol) AK041879 ENSMUST00000194360.1 uc290fdp.1 uc290fdp.2 uc290fdp.1 uc290fdp.2 
ENSMUST00000194361.7 Chst10 ENSMUST00000194361.7 Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-GlcA- (1->3)-beta-D-Gal-(1->4)-D-GlcNAc-R, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis (PubMed:12213450, PubMed:12358771). Sulfates terminal glucuronyl residue of the laminin globular (LG)-domain binding epitope on DAG1/alpha-dystroglycan and prevents further polymerization by LARGE1 glycosyltransferase. Likely defines the chain length of LG epitope, conferring binding specificity to extracellular matrix components (By similarity). Plays a role in down-regulating the steroid hormones. Sulfates glucuronidated estrogens and androgens with an impact in hormone cycle and fertility. Has a preference for glucuronyl moiety at the 3-hydroxyl group of a sterol ring rather than the 17-hydroxyl group, showing high catalytic efficiency for 17beta-estradiol 3-O- (beta-D-glucuronate) and dehydroepiandrosterone 3-O-(beta-D- glucuronate) hormones (PubMed:23269668) (By similarity). (from UniProt Q6PGK7) AK050676 CHSTA_MOUSE Chst10 ENSMUST00000194361.1 ENSMUST00000194361.2 ENSMUST00000194361.3 ENSMUST00000194361.4 ENSMUST00000194361.5 ENSMUST00000194361.6 Q6PGK7 Q8BKU3 Q8BL08 Q8R2Y5 Q91Y40 uc287hnj.1 uc287hnj.2 uc287hnj.3 Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-GlcA- (1->3)-beta-D-Gal-(1->4)-D-GlcNAc-R, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis (PubMed:12213450, PubMed:12358771). Sulfates terminal glucuronyl residue of the laminin globular (LG)-domain binding epitope on DAG1/alpha-dystroglycan and prevents further polymerization by LARGE1 glycosyltransferase. Likely defines the chain length of LG epitope, conferring binding specificity to extracellular matrix components (By similarity). Plays a role in down-regulating the steroid hormones. Sulfates glucuronidated estrogens and androgens with an impact in hormone cycle and fertility. Has a preference for glucuronyl moiety at the 3-hydroxyl group of a sterol ring rather than the 17-hydroxyl group, showing high catalytic efficiency for 17beta-estradiol 3-O- (beta-D-glucuronate) and dehydroepiandrosterone 3-O-(beta-D- glucuronate) hormones (PubMed:23269668) (By similarity). Reaction=3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D- Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol- P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L- Thr-[protein] = 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)- beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D- GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:68304, Rhea:RHEA-COMP:17486, Rhea:RHEA-COMP:17487, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:177355, ChEBI:CHEBI:177363; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68305; Evidence=; Reaction=17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:68696, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136641, ChEBI:CHEBI:178093; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68697; Evidence=; Reaction=17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'- phosphoadenylyl sulfate = 17beta-estradiol 3-O-(3-sulfo-beta-D- glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:68660, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:178094, ChEBI:CHEBI:178095; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68661; Evidence=; Reaction=17beta-estradiol 17-O-(beta-D-glucuronate) + 3'- phosphoadenylyl sulfate = 17beta-estradiol 17-O-(3-sulfo-beta-D- glucuronate) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:68664, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:82961, ChEBI:CHEBI:178096; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68665; Evidence=; Reaction=16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'- phosphoadenylyl sulfate = 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D- glucuronate) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:68668, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136649, ChEBI:CHEBI:178097; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68669; Evidence=; Reaction=16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'- phosphoadenylyl sulfate = 16alpha,17beta-estriol 16-O-(3-sulfo-beta- D-glucuronate) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:68672, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136650, ChEBI:CHEBI:178098; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68673; Evidence=; Reaction=16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'- phosphoadenylyl sulfate = 16alpha,17beta-estriol 17-O-(3-sulfo-beta- D-glucuronate) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:68700, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:178099, ChEBI:CHEBI:178100; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68701; Evidence=; Reaction=3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) = adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D- glucuronate) + H(+); Xref=Rhea:RHEA:68676, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136634, ChEBI:CHEBI:178101; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68677; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta- pregnane 3-O-(beta-D-glucuronate) = 3alpha,20alpha-dihydroxy-5beta- pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'- bisphosphate + H(+); Xref=Rhea:RHEA:68680, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:178102, ChEBI:CHEBI:178103; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68681; Evidence=; Reaction=3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D- glucuronate) = adenosine 3',5'-bisphosphate + H(+) + testosterone 17- O-(3-sulfo-beta-D-glucuronate); Xref=Rhea:RHEA:68684, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136639, ChEBI:CHEBI:178104; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68685; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O- (beta-D-glucuronate) = 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D- glucuronate) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:68688, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:178105, ChEBI:CHEBI:178106; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68689; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta- androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate) = 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:68692, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:178107, ChEBI:CHEBI:178108; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68693; Evidence=; Reaction=3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) = 3alpha-hydroxyetiocholan-17-one 3-O-(3- sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:68704, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:178197, ChEBI:CHEBI:178198; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68705; Evidence=; Steroid metabolism. Protein modification; carbohydrate sulfation. Golgi apparatus membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PGK7-1; Sequence=Displayed; Name=2; IsoId=Q6PGK7-2; Sequence=VSP_012989, VSP_012990, VSP_012991; Mice are viable, fertile and show normal cerebellar granule neuron migration. The anatomy of all major brain areas are histologically normal. However, basal synaptic transmission in pyramidal cells in the CA1 region of the hippocampus are increased and long-term potentiation evoked by theta-burst stimulation are reduced. Mice show an impaired long-term memory and a poorer spatial learning when a short inter-trial interval is used (PubMed:12213450, PubMed:12358771). Mutant female mice are subfertile, have extensive growth of endometrial epithelium associated with increased 17-beta- estradiol levels at pro-estrus phase and dysregulated hormonal cycle (PubMed:23269668). Belongs to the sulfotransferase 2 family. Sequence=BAC34375.1; Type=Erroneous initiation; Evidence=; Sequence=BC056956; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Golgi membrane Golgi apparatus carbohydrate metabolic process learning long-term memory sulfotransferase activity membrane integral component of membrane carbohydrate biosynthetic process HNK-1 sulfotransferase activity transferase activity proteoglycan biosynthetic process uc287hnj.1 uc287hnj.2 uc287hnj.3 
ENSMUST00000194364.2 Gm38192 ENSMUST00000194364.2 Gm38192 (from geneSymbol) ENSMUST00000194364.1 LF197689 uc292isp.1 uc292isp.2 uc292isp.1 uc292isp.2 
ENSMUST00000194367.6 Gm5150 ENSMUST00000194367.6 Gm5150 (from geneSymbol) 381484 DQ055451 ENSMUST00000194367.1 ENSMUST00000194367.2 ENSMUST00000194367.3 ENSMUST00000194367.4 ENSMUST00000194367.5 Gm5150 Q1AN92 Q1AN92_MOUSE uc290dyl.1 uc290dyl.2 molecular_function plasma membrane biological_process membrane integral component of membrane uc290dyl.1 uc290dyl.2 
ENSMUST00000194368.2 Gm37136 ENSMUST00000194368.2 Gm37136 (from geneSymbol) ENSMUST00000194368.1 uc290edj.1 uc290edj.2 uc290edj.1 uc290edj.2 
ENSMUST00000194370.2 1700039I01Rik ENSMUST00000194370.2 1700039I01Rik (from geneSymbol) AK006642 ENSMUST00000194370.1 uc287isi.1 uc287isi.2 uc287isi.1 uc287isi.2 
ENSMUST00000194376.2 Lrriq3 ENSMUST00000194376.2 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14DL3-1; Sequence=Displayed; Name=2; IsoId=Q14DL3-2; Sequence=VSP_029412, VSP_029413; Name=3; IsoId=Q14DL3-3; Sequence=VSP_029414, VSP_029415; (from UniProt Q14DL3) AK015758 ENSMUST00000194376.1 LRIQ3_MOUSE Lrrc44 Q14DL3 Q9D4C3 Q9D562 Q9D5I0 uc008ruw.1 uc008ruw.2 uc008ruw.3 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14DL3-1; Sequence=Displayed; Name=2; IsoId=Q14DL3-2; Sequence=VSP_029412, VSP_029413; Name=3; IsoId=Q14DL3-3; Sequence=VSP_029414, VSP_029415; Sequence=BAB30350.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc008ruw.1 uc008ruw.2 uc008ruw.3 
ENSMUST00000194382.2 Gm37483 ENSMUST00000194382.2 Gm37483 (from geneSymbol) AK089907 ENSMUST00000194382.1 uc287gdu.1 uc287gdu.2 uc287gdu.1 uc287gdu.2 
ENSMUST00000194389.2 Gm37112 ENSMUST00000194389.2 Gm37112 (from geneSymbol) ENSMUST00000194389.1 uc292sqm.1 uc292sqm.2 uc292sqm.1 uc292sqm.2 
ENSMUST00000194396.2 Gm10748 ENSMUST00000194396.2 Gm10748 (from geneSymbol) ENSMUST00000194396.1 uc290dsm.1 uc290dsm.2 uc290dsm.1 uc290dsm.2 
ENSMUST00000194399.2 Trbv13-1 ENSMUST00000194399.2 Trbv13-1 (from geneSymbol) A0A0B4J1P8 A0A0B4J1P8_MOUSE BC089553 ENSMUST00000194399.1 Trbv13-1 uc057lpt.1 uc057lpt.2 uc057lpt.3 uc057lpt.1 uc057lpt.2 uc057lpt.3 
ENSMUST00000194401.2 Gm37774 ENSMUST00000194401.2 Gm37774 (from geneSymbol) ENSMUST00000194401.1 uc289phq.1 uc289phq.2 uc289phq.1 uc289phq.2 
ENSMUST00000194406.2 Gm37754 ENSMUST00000194406.2 Gm37754 (from geneSymbol) ENSMUST00000194406.1 uc287niy.1 uc287niy.2 uc287niy.1 uc287niy.2 
ENSMUST00000194416.2 Gm37452 ENSMUST00000194416.2 Gm37452 (from geneSymbol) AK076415 ENSMUST00000194416.1 uc291opd.1 uc291opd.2 uc291opd.1 uc291opd.2 
ENSMUST00000194417.2 Gm38374 ENSMUST00000194417.2 Gm38374 (from geneSymbol) ENSMUST00000194417.1 uc287jvh.1 uc287jvh.2 uc287jvh.1 uc287jvh.2 
ENSMUST00000194418.2 Pcdhga4 ENSMUST00000194418.2 protocadherin gamma subfamily A, 4 (from RefSeq NM_033587.4) ENSMUST00000194418.1 NM_033587 PCDG4_MOUSE Pcdhga4 Q80Y31 Q91XY4 uc008eqp.1 uc008eqp.2 uc008eqp.3 uc008eqp.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity). Cell membrane ; Single-pass type I membrane protein Expressed in stage P0-P2 spinal astrocytes, stage P15 hippocampus where expression is detected in some pyramidal neurons, and stage P18 cerebellum where strong expression is detected in a few scattered Purkinje cells and weak expression in neighboring Purkinje cells. molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules spermatogenesis membrane integral component of membrane uc008eqp.1 uc008eqp.2 uc008eqp.3 uc008eqp.4 
ENSMUST00000194420.2 Gm37980 ENSMUST00000194420.2 Gm37980 (from geneSymbol) ENSMUST00000194420.1 uc288ihw.1 uc288ihw.2 uc288ihw.1 uc288ihw.2 
ENSMUST00000194422.2 Gm36943 ENSMUST00000194422.2 Gm36943 (from geneSymbol) ENSMUST00000194422.1 uc287ipy.1 uc287ipy.2 uc287ipy.1 uc287ipy.2 
ENSMUST00000194425.2 4930533L02Rik ENSMUST00000194425.2 4930533L02Rik (from geneSymbol) ENSMUST00000194425.1 uc291vhc.1 uc291vhc.2 uc291vhc.1 uc291vhc.2 
ENSMUST00000194431.2 Gm38272 ENSMUST00000194431.2 Gm38272 (from geneSymbol) ENSMUST00000194431.1 uc287izr.1 uc287izr.2 uc287izr.1 uc287izr.2 
ENSMUST00000194442.2 Gm37535 ENSMUST00000194442.2 Gm37535 (from geneSymbol) ENSMUST00000194442.1 uc287hyr.1 uc287hyr.2 uc287hyr.1 uc287hyr.2 
ENSMUST00000194444.2 2900042K21Rik ENSMUST00000194444.2 2900042K21Rik (from geneSymbol) ENSMUST00000194444.1 uc287owk.1 uc287owk.2 uc287owk.1 uc287owk.2 
ENSMUST00000194451.2 Gm37437 ENSMUST00000194451.2 Gm37437 (from geneSymbol) AK134374 ENSMUST00000194451.1 uc289tgg.1 uc289tgg.2 uc289tgg.1 uc289tgg.2 
ENSMUST00000194454.2 Gm38385 ENSMUST00000194454.2 Gm38385 (from geneSymbol) ENSMUST00000194454.1 uc287gdn.1 uc287gdn.2 uc287gdn.1 uc287gdn.2 
ENSMUST00000194459.2 Gm38352 ENSMUST00000194459.2 Gm38352 (from geneSymbol) AK133632 ENSMUST00000194459.1 uc287mrl.1 uc287mrl.2 uc287mrl.1 uc287mrl.2 
ENSMUST00000194465.2 Gm37285 ENSMUST00000194465.2 Gm37285 (from geneSymbol) AK082097 ENSMUST00000194465.1 uc287ixj.1 uc287ixj.2 uc287ixj.1 uc287ixj.2 
ENSMUST00000194467.2 A130071D04Rik ENSMUST00000194467.2 A130071D04Rik (from geneSymbol) AK038155 ENSMUST00000194467.1 uc287mer.1 uc287mer.2 uc287mer.1 uc287mer.2 
ENSMUST00000194468.2 A630035G10Rik ENSMUST00000194468.2 A630035G10Rik (from geneSymbol) AK040041 ENSMUST00000194468.1 uc287nvj.1 uc287nvj.2 uc287nvj.1 uc287nvj.2 
ENSMUST00000194472.2 Gm37221 ENSMUST00000194472.2 Gm37221 (from geneSymbol) ENSMUST00000194472.1 uc287lhk.1 uc287lhk.2 uc287lhk.1 uc287lhk.2 
ENSMUST00000194474.2 1700047N06Rik ENSMUST00000194474.2 1700047N06Rik (from geneSymbol) AK006719 ENSMUST00000194474.1 uc287glm.1 uc287glm.2 uc287glm.1 uc287glm.2 
ENSMUST00000194479.2 Gm37192 ENSMUST00000194479.2 Gm37192 (from geneSymbol) ENSMUST00000194479.1 LF197493 uc292foi.1 uc292foi.2 uc292foi.1 uc292foi.2 
ENSMUST00000194483.2 Gm37534 ENSMUST00000194483.2 Gm37534 (from geneSymbol) AK040563 ENSMUST00000194483.1 uc287mec.1 uc287mec.2 uc287mec.1 uc287mec.2 
ENSMUST00000194484.2 Gm38223 ENSMUST00000194484.2 Gm38223 (from geneSymbol) AK158762 ENSMUST00000194484.1 uc287goj.1 uc287goj.2 uc287goj.1 uc287goj.2 
ENSMUST00000194486.2 Gm37827 ENSMUST00000194486.2 Gm37827 (from geneSymbol) AK081634 ENSMUST00000194486.1 uc291opg.1 uc291opg.2 uc291opg.1 uc291opg.2 
ENSMUST00000194487.2 Gm37366 ENSMUST00000194487.2 Gm37366 (from geneSymbol) AK047275 ENSMUST00000194487.1 uc287peo.1 uc287peo.2 uc287peo.1 uc287peo.2 
ENSMUST00000194490.2 Gm37876 ENSMUST00000194490.2 Gm37876 (from geneSymbol) AK082589 ENSMUST00000194490.1 uc290gia.1 uc290gia.2 uc290gia.1 uc290gia.2 
ENSMUST00000194491.2 Gm37230 ENSMUST00000194491.2 Gm37230 (from geneSymbol) BC119581 ENSMUST00000194491.1 uc292lcm.1 uc292lcm.2 uc292lcm.1 uc292lcm.2 
ENSMUST00000194495.2 Gm38189 ENSMUST00000194495.2 Gm38189 (from geneSymbol) ENSMUST00000194495.1 uc287mkl.1 uc287mkl.2 uc287mkl.1 uc287mkl.2 
ENSMUST00000194497.2 Gm37353 ENSMUST00000194497.2 Gm37353 (from geneSymbol) ENSMUST00000194497.1 LF234970 uc290ekn.1 uc290ekn.2 uc290ekn.1 uc290ekn.2 
ENSMUST00000194500.2 Gm37324 ENSMUST00000194500.2 Gm37324 (from geneSymbol) DQ545225 ENSMUST00000194500.1 uc290kui.1 uc290kui.2 uc290kui.1 uc290kui.2 
ENSMUST00000194502.2 Gm38178 ENSMUST00000194502.2 Gm38178 (from geneSymbol) ENSMUST00000194502.1 uc287gnc.1 uc287gnc.2 uc287gnc.1 uc287gnc.2 
ENSMUST00000194506.2 Gm37598 ENSMUST00000194506.2 Gm37598 (from geneSymbol) ENSMUST00000194506.1 LF204561 uc287oft.1 uc287oft.2 uc287oft.1 uc287oft.2 
ENSMUST00000194507.2 Gm38325 ENSMUST00000194507.2 Gm38325 (from geneSymbol) AK132121 ENSMUST00000194507.1 uc287nkl.1 uc287nkl.2 uc287nkl.1 uc287nkl.2 
ENSMUST00000194508.2 Gm36936 ENSMUST00000194508.2 Gm36936 (from geneSymbol) ENSMUST00000194508.1 LF204658 uc292irr.1 uc292irr.2 uc292irr.1 uc292irr.2 
ENSMUST00000194509.2 Gm38191 ENSMUST00000194509.2 Gm38191 (from geneSymbol) ENSMUST00000194509.1 uc288ojz.1 uc288ojz.2 uc288ojz.1 uc288ojz.2 
ENSMUST00000194512.2 Gm37514 ENSMUST00000194512.2 Gm37514 (from geneSymbol) ENSMUST00000194512.1 uc287sqi.1 uc287sqi.2 uc287sqi.1 uc287sqi.2 
ENSMUST00000194514.2 4930509J09Rik ENSMUST00000194514.2 RIKEN cDNA 4930509J09 gene (from RefSeq NR_040547.1) ENSMUST00000194514.1 NR_040547 uc029umn.1 uc029umn.2 uc029umn.1 uc029umn.2 
ENSMUST00000194515.2 Gm37762 ENSMUST00000194515.2 Gm37762 (from geneSymbol) ENSMUST00000194515.1 uc288vjc.1 uc288vjc.2 uc288vjc.1 uc288vjc.2 
ENSMUST00000194517.2 Gm37834 ENSMUST00000194517.2 Gm37834 (from geneSymbol) AK083850 ENSMUST00000194517.1 uc290eiz.1 uc290eiz.2 uc290eiz.1 uc290eiz.2 
ENSMUST00000194519.2 Gm37548 ENSMUST00000194519.2 Gm37548 (from geneSymbol) ENSMUST00000194519.1 uc290fbo.1 uc290fbo.2 uc290fbo.1 uc290fbo.2 
ENSMUST00000194520.2 Gm37677 ENSMUST00000194520.2 Gm37677 (from geneSymbol) ENSMUST00000194520.1 LF315948 uc287lxr.1 uc287lxr.2 uc287lxr.1 uc287lxr.2 
ENSMUST00000194524.2 Gm37806 ENSMUST00000194524.2 Gm37806 (from geneSymbol) ENSMUST00000194524.1 uc290gac.1 uc290gac.2 uc290gac.1 uc290gac.2 
ENSMUST00000194525.2 Gm37402 ENSMUST00000194525.2 Gm37402 (from geneSymbol) ENSMUST00000194525.1 uc289gyx.1 uc289gyx.2 uc289gyx.1 uc289gyx.2 
ENSMUST00000194526.2 A730089K16Rik ENSMUST00000194526.2 A730089K16Rik (from geneSymbol) AK036552 ENSMUST00000194526.1 uc290wns.1 uc290wns.2 uc290wns.1 uc290wns.2 
ENSMUST00000194528.3 Catspere1 ENSMUST00000194528.3 cation channel sperm associated auxiliary subunit epsilon 1 (from RefSeq NM_001368823.1) A0A5F8MPP5 A0A5F8MPP5_MOUSE Catspere1 ENSMUST00000194528.1 ENSMUST00000194528.2 NM_001368823 uc287ogp.1 uc287ogp.2 uc287ogp.3 Belongs to the CATSPERD family. uc287ogp.1 uc287ogp.2 uc287ogp.3 
ENSMUST00000194529.2 Gm38194 ENSMUST00000194529.2 Gm38194 (from geneSymbol) AB351233 ENSMUST00000194529.1 uc287pfm.1 uc287pfm.2 uc287pfm.1 uc287pfm.2 
ENSMUST00000194532.2 Gm31258 ENSMUST00000194532.2 Gm31258 (from geneSymbol) ENSMUST00000194532.1 uc289fop.1 uc289fop.2 uc289fop.1 uc289fop.2 
ENSMUST00000194534.2 C130089K02Rik ENSMUST00000194534.2 C130089K02Rik (from geneSymbol) AK038829 ENSMUST00000194534.1 uc290fei.1 uc290fei.2 uc290fei.1 uc290fei.2 
ENSMUST00000194535.2 Gm37051 ENSMUST00000194535.2 Gm37051 (from geneSymbol) ENSMUST00000194535.1 uc287gyd.1 uc287gyd.2 uc287gyd.1 uc287gyd.2 
ENSMUST00000194537.2 Gm38319 ENSMUST00000194537.2 Gm38319 (from geneSymbol) AK145694 ENSMUST00000194537.1 uc287gos.1 uc287gos.2 uc287gos.1 uc287gos.2 
ENSMUST00000194539.2 Gm37010 ENSMUST00000194539.2 Gm37010 (from geneSymbol) AK138889 ENSMUST00000194539.1 uc287nvm.1 uc287nvm.2 uc287nvm.1 uc287nvm.2 
ENSMUST00000194541.3 Rncr4 ENSMUST00000194541.3 Rncr4 (from geneSymbol) ENSMUST00000194541.1 ENSMUST00000194541.2 uc291ddu.1 uc291ddu.2 uc291ddu.1 uc291ddu.2 
ENSMUST00000194542.6 Keap1 ENSMUST00000194542.6 kelch-like ECH-associated protein 1, transcript variant 4 (from RefSeq NM_001110307.1) ENSMUST00000194542.1 ENSMUST00000194542.2 ENSMUST00000194542.3 ENSMUST00000194542.4 ENSMUST00000194542.5 Inrf2 KEAP1_MOUSE Keap1 Kiaa0132 NM_001110307 Q3U243 Q3U8N7 Q547S3 Q6ZQI6 Q8BQY3 Q9Z2X8 uc009okr.1 uc009okr.2 uc009okr.3 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:9887101, PubMed:12682069, PubMed:15282312, PubMed:15367669, PubMed:15581590). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:9887101, PubMed:12193649, PubMed:14764894). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:12193649, PubMed:20498371, PubMed:22014577, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20421418, PubMed:20173742, PubMed:24011591). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity). Ubiquitin ligase activity of the BCR(KEAP1) complex is inhibited by oxidative stress and electrophile metabolites such as sulforaphane (PubMed:12193649, PubMed:14764894, PubMed:22014577). Electrophile metabolites react with reactive cysteine residues in KEAP1 and trigger non-enzymatic covalent modifications of these cysteine residues, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex (PubMed:20498371, PubMed:22014577). Selective autophagy also inactivates the BCR(KEAP1) complex via interaction between KEAP1 and SQSTM1/p62, which sequesters the complex in inclusion bodies and promotes its degradation (PubMed:20421418, PubMed:20173742, PubMed:24011591). Protein modification; protein ubiquitination. Component of the BCR(KEAP1) E3 ubiquitin ligase complex, at least composed of 2 molecules of CUL3, 2 molecules of KEAP1, and RBX1 (PubMed:15282312, PubMed:16790436, PubMed:27697860). Interacts with NFE2L2/NRF2; the interaction is direct (PubMed:15282312, PubMed:15367669, PubMed:15581590, PubMed:16790436, PubMed:16581765, PubMed:27697860, PubMed:16507366). Forms a ternary complex with NFE2L2/NRF2 and PGAM5 (By similarity). Interacts with (phosphorylated) SQSTM1/p62; the interaction is direct and inactivates the BCR(KEAP1) complex by sequestering it in inclusion bodies, promoting its degradation (PubMed:20495340, PubMed:20421418, PubMed:20173742, PubMed:24011591). Interacts with NFE2L1 (By similarity). Interacts with BPTF and PTMA (By similarity). Interacts with MAP1LC3B (By similarity). Interacts indirectly with ENC1 (By similarity). Interacts with SESN1 and SESN2 (By similarity). Interacts with HSP90AA1 and HSP90AB1 (By similarity). Q9Z2X8; Q9Z2X8: Keap1; NbExp=3; IntAct=EBI-647110, EBI-647110; Q9Z2X8; Q60795: Nfe2l2; NbExp=23; IntAct=EBI-647110, EBI-642563; Q9Z2X8; Q64337: Sqstm1; NbExp=6; IntAct=EBI-647110, EBI-645025; Q9Z2X8; Q13501: SQSTM1; Xeno; NbExp=2; IntAct=EBI-647110, EBI-307104; Cytoplasm cleus Note=Mainly cytoplasmic (PubMed:17903176). In response to selective autophagy, relocalizes to inclusion bodies following interaction with SQSTM1/p62 (PubMed:20495340, PubMed:20421418, PubMed:20173742). The Kelch repeats mediate interaction with NFE2L2/NRF2, BPTF and PGAM5. KEAP1 contains reactive cysteine residues that act as sensors for endogenously produced and exogenously encountered small molecules, which react with sulfhydryl groups and modify the cysteine sensors, leading to impair ability of the BCR(KEAP1) complex to ubiquitinate target proteins. Non-enzymatic covalent modifications of reactive cysteines by electrophile metabolites inactivate the BCR(KEAP1) complex (PubMed:12193649, PubMed:20498371, PubMed:22014577). Accumulation of fumarate promotes the formation of cysteine S-succination (S-(2- succinyl)cysteine), leading to inactivate the BCR(KEAP1) complex and promote NFE2L2/NRF2 nuclear accumulation and activation (PubMed:22014577). Nitric oxide-dependent 8-Nitro-cGMP formation promotes cysteine guanylation (S-cGMP-cysteine), leading to NFE2L2/NRF2 nuclear accumulation and activation (PubMed:17906641, PubMed:20498371). Itaconate, an anti-inflammatory metabolite generated in response to lipopolysaccharide, alkylates cysteines, activating NFE2L2/NRF2 (PubMed:29590092). Methylglyoxal, a reactive metabolite that accumulates when the glycolytic enzyme PGK1 is inhibited, promotes formation of a methylimidazole cross-link between proximal Cys-151 and Arg-135 on another KEAP1 molecule, resulting in an inactive dimer that inactivates the BCR(KEAP1) complex (By similarity). Degraded via a proteasomal-independent process during selective autophagy: interaction with phosphorylated SQSTM1/p62 sequesters KEAP1 in inclusion bodies, leading to its degradation. Auto-ubiquitinated by the BCR(KEAP1) complex. Quinone-induced oxidative stress, but not sulforaphane, increases its ubiquitination. Ubiquitination and subsequent degradation is most pronounced following prolonged exposure of cells to oxidative stress, particularly in glutathione-deficient cells that are highly susceptible to oxidative stress. Early postnatal lethality caused by abnormal cornification (PubMed:14517554). Mice survive until weaning and probably die from malnutrition resulting from hyperkeratosis in the esophagus and forestomach that cause gastric obstruction (PubMed:14517554). Defects are caused by constitutive activation Nfe2l2/Nrf2, leading to constitutive expression of phase 2 detoxifying enzymes (PubMed:14517554). Mice lacking both Nfe2l2/Nrf2 and Keap1 reverse the hyperkeratosis phenotype and are healthy and viable in normal conditions (PubMed:14517554). Belongs to the KEAP1 family. According to a report, not degraded in response to autophagy (PubMed:20495340). However, publications have shown that KEAP1 is degraded via a proteasomal-independent process during selective autophagy (PubMed:22872865, PubMed:24011591). The mechanism of inactivation of the BCR(KEAP1) complex by covalent modifications of reactive cysteines is unclear. Covalent modifications were initially thought to disrupt interaction between KEAP1 and NFE2L2/NRF2 (PubMed:12193649). Recent publications suggest that cysteine modifications disrupt the interaction between KEAP1 and CUL3 without affecting the interaction between KEAP1 and NFE2L2/NRF2 (By similarity). Sequence=BAC97871.1; Type=Erroneous initiation; Evidence=; in utero embryonic development protein binding nucleus nucleoplasm cytoplasm endoplasmic reticulum microtubule organizing center cytosol actin filament cell-cell adherens junction focal adhesion regulation of transcription, DNA-templated transcription factor binding proteasomal ubiquitin-independent protein catabolic process negative regulation of gene expression protein ubiquitination midbody Cul3-RING ubiquitin ligase complex macromolecular complex identical protein binding protein homodimerization activity cytoplasmic sequestering of transcription factor regulation of epidermal cell differentiation protein oligomerization cellular response to interleukin-4 disordered domain specific binding uc009okr.1 uc009okr.2 uc009okr.3 
ENSMUST00000194543.4 Mia3 ENSMUST00000194543.4 MIA SH3 domain ER export factor 3 (from RefSeq NM_177389.4) A0A0R4J2D3 A0A0R4J2D3_MOUSE ENSMUST00000194543.1 ENSMUST00000194543.2 ENSMUST00000194543.3 Mia3 NM_177389 uc287ore.1 uc287ore.2 uc287ore.3 Endoplasmic reticulum membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein uc287ore.1 uc287ore.2 uc287ore.3 
ENSMUST00000194544.2 Gm38666 ENSMUST00000194544.2 Gm38666 (from geneSymbol) BC160380 ENSMUST00000194544.1 Gm38666 Q8K491 Q8K491_MOUSE uc289oth.1 uc289oth.2 integral component of plasma membrane cell adhesion uc289oth.1 uc289oth.2 
ENSMUST00000194545.2 Gm37731 ENSMUST00000194545.2 Gm37731 (from geneSymbol) AK047754 ENSMUST00000194545.1 uc287myz.1 uc287myz.2 uc287myz.1 uc287myz.2 
ENSMUST00000194549.2 Gm38269 ENSMUST00000194549.2 Gm38269 (from geneSymbol) ENSMUST00000194549.1 uc287mjl.1 uc287mjl.2 uc287mjl.1 uc287mjl.2 
ENSMUST00000194551.2 Gm36969 ENSMUST00000194551.2 Gm36969 (from geneSymbol) ENSMUST00000194551.1 uc287kvj.1 uc287kvj.2 uc287kvj.1 uc287kvj.2 
ENSMUST00000194556.2 Gm37647 ENSMUST00000194556.2 Gm37647 (from geneSymbol) ENSMUST00000194556.1 uc290dug.1 uc290dug.2 uc290dug.1 uc290dug.2 
ENSMUST00000194558.6 Kpna4 ENSMUST00000194558.6 karyopherin subunit alpha 4 (from RefSeq NM_008467.4) ENSMUST00000194558.1 ENSMUST00000194558.2 ENSMUST00000194558.3 ENSMUST00000194558.4 ENSMUST00000194558.5 Kpna4 NM_008467 Q4FJX1 Q4FJX1_MOUSE uc008pme.1 uc008pme.2 Functions in nuclear protein import. Belongs to the importin alpha family. nucleus cytoplasm protein import into nucleus protein transport nuclear membrane nuclear import signal receptor activity uc008pme.1 uc008pme.2 
ENSMUST00000194560.2 Gm37002 ENSMUST00000194560.2 Gm37002 (from geneSymbol) ENSMUST00000194560.1 uc288vzm.1 uc288vzm.2 uc288vzm.1 uc288vzm.2 
ENSMUST00000194563.6 Tmem131 ENSMUST00000194563.6 May play a role in the immune response to viral infection. (from UniProt O70472) AF060565 D1Bwg0491e ENSMUST00000194563.1 ENSMUST00000194563.2 ENSMUST00000194563.3 ENSMUST00000194563.4 ENSMUST00000194563.5 Kiaa0257 O70472 Q8CHH3 Rw1 TM131_MOUSE uc287hjh.1 uc287hjh.2 May play a role in the immune response to viral infection. Membrane ; Multi-pass membrane protein Belongs to the TMEM131 family. Sequence=AAC15232.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; molecular_function membrane integral component of membrane uc287hjh.1 uc287hjh.2 
ENSMUST00000194564.2 Gm37138 ENSMUST00000194564.2 Gm37138 (from geneSymbol) DQ719177 ENSMUST00000194564.1 uc287gpq.1 uc287gpq.2 uc287gpq.1 uc287gpq.2 
ENSMUST00000194567.2 Gm37362 ENSMUST00000194567.2 Gm37362 (from geneSymbol) ENSMUST00000194567.1 uc287nbk.1 uc287nbk.2 uc287nbk.1 uc287nbk.2 
ENSMUST00000194570.2 Gm37072 ENSMUST00000194570.2 Gm37072 (from geneSymbol) ENSMUST00000194570.1 uc287nbg.1 uc287nbg.2 uc287nbg.1 uc287nbg.2 
ENSMUST00000194571.2 Gm37873 ENSMUST00000194571.2 Gm37873 (from geneSymbol) AK034006 ENSMUST00000194571.1 uc287nak.1 uc287nak.2 uc287nak.1 uc287nak.2 
ENSMUST00000194572.3 A930014E01Rik ENSMUST00000194572.3 A930014E01Rik (from geneSymbol) AK020856 ENSMUST00000194572.1 ENSMUST00000194572.2 uc290dvo.1 uc290dvo.2 uc290dvo.1 uc290dvo.2 
ENSMUST00000194573.2 Gm37850 ENSMUST00000194573.2 Gm37850 (from geneSymbol) ENSMUST00000194573.1 uc292kyi.1 uc292kyi.2 uc292kyi.1 uc292kyi.2 
ENSMUST00000194579.2 Gm37397 ENSMUST00000194579.2 Gm37397 (from geneSymbol) ENSMUST00000194579.1 LF315178 uc291euu.1 uc291euu.2 uc291euu.1 uc291euu.2 
ENSMUST00000194581.2 Ighv1-62-2 ENSMUST00000194581.2 Ighv1-62-2 (from geneSymbol) A0A0A6YXZ4 A0A0A6YXZ4_MOUSE BC018322 ENSMUST00000194581.1 Ighv1-62-2 uc288kbe.1 uc288kbe.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kbe.1 uc288kbe.2 
ENSMUST00000194583.3 Gm37280 ENSMUST00000194583.3 Gm37280 (from geneSymbol) ENSMUST00000194583.1 ENSMUST00000194583.2 uc287ogl.1 uc287ogl.2 uc287ogl.3 uc287ogl.1 uc287ogl.2 uc287ogl.3 
ENSMUST00000194586.2 Gm38036 ENSMUST00000194586.2 Gm38036 (from geneSymbol) AK051065 ENSMUST00000194586.1 uc287pdx.1 uc287pdx.2 uc287pdx.1 uc287pdx.2 
ENSMUST00000194588.2 Gm37342 ENSMUST00000194588.2 Gm37342 (from geneSymbol) ENSMUST00000194588.1 uc290fdu.1 uc290fdu.2 uc290fdu.1 uc290fdu.2 
ENSMUST00000194590.2 Gm37495 ENSMUST00000194590.2 Gm37495 (from geneSymbol) ENSMUST00000194590.1 uc288wkv.1 uc288wkv.2 uc288wkv.1 uc288wkv.2 
ENSMUST00000194594.2 Gm38110 ENSMUST00000194594.2 Gm38110 (from geneSymbol) AB346118 ENSMUST00000194594.1 uc287hus.1 uc287hus.2 uc287hus.1 uc287hus.2 
ENSMUST00000194598.6 Syngap1 ENSMUST00000194598.6 synaptic Ras GTPase activating protein 1 homolog (rat), transcript variant 2 (from RefSeq NM_001371033.1) ENSMUST00000194598.1 ENSMUST00000194598.2 ENSMUST00000194598.3 ENSMUST00000194598.4 ENSMUST00000194598.5 F6SEU4 NM_001371033 SYGP1_MOUSE uc008bfa.1 uc008bfa.2 uc008bfa.3 uc008bfa.4 This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Homozygous null mutations result in early post-embryonic lethality, while heterozygous mutant mice display a variety of phenotypes that include learning and memory defects, hyperactivity, and audiogenic seizures. [provided by RefSeq, Nov 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: MG600593.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). Interacts with KLHL17, CAMK2A and CAMK2B. Interacts with MPDZ (By similarity). F6SEU4; Q9D415: Dlgap1; NbExp=3; IntAct=EBI-5797569, EBI-400152; F6SEU4; P16056: Met; NbExp=3; IntAct=EBI-5797569, EBI-1798780; Membrane ; Peripheral membrane protein Synapse Note=Mostly in excitatory glutamatergic synapses (By similarity). receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity (By similarity). The C2 domain is required for RapGAP activity. GTPase activator activity protein binding plasma membrane signal transduction Ras protein signal transduction pattern specification process visual learning postsynaptic density membrane dendrite development SH3 domain binding protein kinase binding cell junction regulation of GTPase activity receptor clustering dendritic shaft regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of GTPase activity synapse negative regulation of Ras protein signal transduction regulation of synaptic plasticity regulation of long-term neuronal synaptic plasticity negative regulation of axonogenesis regulation of synapse structure or activity maintenance of postsynaptic specialization structure glutamatergic synapse postsynaptic density, intracellular component uc008bfa.1 uc008bfa.2 uc008bfa.3 uc008bfa.4 
ENSMUST00000194599.2 A430027C01Rik ENSMUST00000194599.2 A430027C01Rik (from geneSymbol) AK039904 ENSMUST00000194599.1 uc292ior.1 uc292ior.2 uc292ior.1 uc292ior.2 
ENSMUST00000194600.2 Gm38235 ENSMUST00000194600.2 Gm38235 (from geneSymbol) AK139025 ENSMUST00000194600.1 uc287kxc.1 uc287kxc.2 uc287kxc.1 uc287kxc.2 
ENSMUST00000194601.2 Gm38156 ENSMUST00000194601.2 Gm38156 (from geneSymbol) AK048917 ENSMUST00000194601.1 uc289tdu.1 uc289tdu.2 uc289tdu.1 uc289tdu.2 
ENSMUST00000194602.2 Gm38259 ENSMUST00000194602.2 Gm38259 (from geneSymbol) ENSMUST00000194602.1 uc287gil.1 uc287gil.2 uc287gil.1 uc287gil.2 
ENSMUST00000194607.2 Gm37664 ENSMUST00000194607.2 Gm37664 (from geneSymbol) ENSMUST00000194607.1 uc287onq.1 uc287onq.2 uc287onq.1 uc287onq.2 
ENSMUST00000194609.2 Gm37043 ENSMUST00000194609.2 Gm37043 (from geneSymbol) AK139208 ENSMUST00000194609.1 uc287lfr.1 uc287lfr.2 uc287lfr.1 uc287lfr.2 
ENSMUST00000194610.2 Gm38375 ENSMUST00000194610.2 Gm38375 (from geneSymbol) AK081047 ENSMUST00000194610.1 uc292jtq.1 uc292jtq.2 uc292jtq.1 uc292jtq.2 
ENSMUST00000194611.2 1700063I16Rik ENSMUST00000194611.2 1700063I16Rik (from geneSymbol) AK018872 ENSMUST00000194611.1 uc287nop.1 uc287nop.2 uc287nop.1 uc287nop.2 
ENSMUST00000194616.2 Gm37744 ENSMUST00000194616.2 Gm37744 (from geneSymbol) AK039545 ENSMUST00000194616.1 uc287jhe.1 uc287jhe.2 uc287jhe.1 uc287jhe.2 
ENSMUST00000194625.2 Ighv1-23 ENSMUST00000194625.2 Ighv1-23 (from geneSymbol) A0A0A6YVW3 A0A0A6YVW3_MOUSE BC003435 ENSMUST00000194625.1 Ighv1-23 uc288jyn.1 uc288jyn.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jyn.1 uc288jyn.2 
ENSMUST00000194626.2 Gm37819 ENSMUST00000194626.2 Gm37819 (from geneSymbol) AK131691 ENSMUST00000194626.1 uc290fal.1 uc290fal.2 uc290fal.1 uc290fal.2 
ENSMUST00000194629.2 Gm6209 ENSMUST00000194629.2 Gm6209 (from geneSymbol) AK138462 ENSMUST00000194629.1 uc008pdk.1 uc008pdk.2 uc008pdk.3 uc008pdk.1 uc008pdk.2 uc008pdk.3 
ENSMUST00000194630.2 Gm37279 ENSMUST00000194630.2 Gm37279 (from geneSymbol) ENSMUST00000194630.1 uc290fpr.1 uc290fpr.2 uc290fpr.1 uc290fpr.2 
ENSMUST00000194631.2 Gm37151 ENSMUST00000194631.2 Gm37151 (from geneSymbol) AK155586 ENSMUST00000194631.1 uc287hbh.1 uc287hbh.2 uc287hbh.1 uc287hbh.2 
ENSMUST00000194640.2 Gm37526 ENSMUST00000194640.2 Gm37526 (from geneSymbol) ENSMUST00000194640.1 uc290feg.1 uc290feg.2 uc290feg.1 uc290feg.2 
ENSMUST00000194641.6 Elf2 ENSMUST00000194641.6 E74-like factor 2, transcript variant 1 (from RefSeq NM_023502.2) ELF2_MOUSE ENSMUST00000194641.1 ENSMUST00000194641.2 ENSMUST00000194641.3 ENSMUST00000194641.4 ENSMUST00000194641.5 Elf2 NM_023502 Nerf Q6NST2 Q8BTX8 Q9JHC7 Q9JHC8 Q9JHC9 Q9JHD0 uc008pdr.1 uc008pdr.2 uc008pdr.3 uc008pdr.4 Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter. Interacts with LIM domains of LMO2. Interacts via its N- terminal region with RUNX1. Nucleus. Event=Alternative splicing; Named isoforms=4; Name=4; IsoId=Q9JHC9-1; Sequence=Displayed; Name=1 ; Synonyms=elf-2a ; IsoId=Q9JHC9-2; Sequence=VSP_014160; Name=2 ; Synonyms=elf-2b ; IsoId=Q9JHC9-3; Sequence=VSP_014159, VSP_014160; Name=3; IsoId=Q9JHC9-4; Sequence=VSP_014159; Expressed in all tissues examined. Highest levels in thymocytes and bone marrow. Belongs to the ETS family. RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nuclear body cell differentiation sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated uc008pdr.1 uc008pdr.2 uc008pdr.3 uc008pdr.4 
ENSMUST00000194642.4 Gm37027 ENSMUST00000194642.4 Gm37027 (from geneSymbol) AK044392 ENSMUST00000194642.1 ENSMUST00000194642.2 ENSMUST00000194642.3 uc287pej.1 uc287pej.2 uc287pej.3 uc287pej.4 uc287pej.1 uc287pej.2 uc287pej.3 uc287pej.4 
ENSMUST00000194643.2 Gm37381 ENSMUST00000194643.2 Gm37381 (from geneSymbol) AK135874 ENSMUST00000194643.1 uc287gdp.1 uc287gdp.2 uc287gdp.1 uc287gdp.2 
ENSMUST00000194644.2 Gm37628 ENSMUST00000194644.2 Gm37628 (from geneSymbol) ENSMUST00000194644.1 uc287gyf.1 uc287gyf.2 uc287gyf.1 uc287gyf.2 
ENSMUST00000194645.2 Gm37743 ENSMUST00000194645.2 Gm37743 (from geneSymbol) ENSMUST00000194645.1 uc288wvp.1 uc288wvp.2 uc288wvp.1 uc288wvp.2 
ENSMUST00000194646.2 E230020A03Rik ENSMUST00000194646.2 E230020A03Rik (from geneSymbol) AK087593 ENSMUST00000194646.1 uc291opf.1 uc291opf.2 uc291opf.1 uc291opf.2 
ENSMUST00000194647.2 Gm37936 ENSMUST00000194647.2 Gm37936 (from geneSymbol) AK039731 ENSMUST00000194647.1 uc287liw.1 uc287liw.2 uc287liw.1 uc287liw.2 
ENSMUST00000194648.2 6820402A03Rik ENSMUST00000194648.2 6820402A03Rik (from geneSymbol) ENSMUST00000194648.1 uc287ixi.1 uc287ixi.2 uc287ixi.1 uc287ixi.2 
ENSMUST00000194651.2 AY702102 ENSMUST00000194651.2 AY702102 (from geneSymbol) ENSMUST00000194651.1 uc057bpi.1 uc057bpi.2 uc057bpi.3 uc057bpi.1 uc057bpi.2 uc057bpi.3 
ENSMUST00000194653.2 Gm38117 ENSMUST00000194653.2 Gm38117 (from geneSymbol) ENSMUST00000194653.1 uc287usl.1 uc287usl.2 uc287usl.1 uc287usl.2 
ENSMUST00000194664.2 Gm37764 ENSMUST00000194664.2 Gm37764 (from geneSymbol) AK044367 ENSMUST00000194664.1 uc287mle.1 uc287mle.2 uc287mle.1 uc287mle.2 
ENSMUST00000194665.2 Gm10728 ENSMUST00000194665.2 Gm10728 (from geneSymbol) ENSMUST00000194665.1 uc290fec.1 uc290fec.2 uc290fec.1 uc290fec.2 
ENSMUST00000194667.2 A330074H02Rik ENSMUST00000194667.2 A330074H02Rik (from geneSymbol) ENSMUST00000194667.1 uc291rre.1 uc291rre.2 uc291rre.1 uc291rre.2 
ENSMUST00000194673.6 Gm37721 ENSMUST00000194673.6 Gm37721 (from geneSymbol) ENSMUST00000194673.1 ENSMUST00000194673.2 ENSMUST00000194673.3 ENSMUST00000194673.4 ENSMUST00000194673.5 uc292sod.1 uc292sod.2 uc292sod.1 uc292sod.2 
ENSMUST00000194677.6 Lamb3 ENSMUST00000194677.6 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (from UniProt Q61087) AK155769 ENSMUST00000194677.1 ENSMUST00000194677.2 ENSMUST00000194677.3 ENSMUST00000194677.4 ENSMUST00000194677.5 LAMB3_MOUSE Q61087 Q91V90 uc007eee.1 uc007eee.2 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein). Interacts with ECM1 (By similarity). Secreted, extracellular space, extracellular matrix, basement membrane. Found in the basement membranes (major component). The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. Domain VI is globular. integrin binding extracellular matrix structural constituent extracellular region basement membrane laminin-5 complex cell adhesion animal organ morphogenesis tissue development cell migration substrate adhesion-dependent cell spreading endodermal cell differentiation laminin complex macromolecular complex binding brown fat cell differentiation basement membrane assembly uc007eee.1 uc007eee.2 
ENSMUST00000194678.2 Gm37063 ENSMUST00000194678.2 Gm37063 (from geneSymbol) ENSMUST00000194678.1 uc289foy.1 uc289foy.2 uc289foy.1 uc289foy.2 
ENSMUST00000194679.2 Gm37651 ENSMUST00000194679.2 Gm37651 (from geneSymbol) AK075644 ENSMUST00000194679.1 uc289wqa.1 uc289wqa.2 uc289wqa.1 uc289wqa.2 
ENSMUST00000194680.2 Gm37341 ENSMUST00000194680.2 Gm37341 (from geneSymbol) ENSMUST00000194680.1 uc288wba.1 uc288wba.2 uc288wba.1 uc288wba.2 
ENSMUST00000194683.2 Gm37499 ENSMUST00000194683.2 Gm37499 (from geneSymbol) AK135208 ENSMUST00000194683.1 uc289tfc.1 uc289tfc.2 uc289tfc.1 uc289tfc.2 
ENSMUST00000194686.2 Gm37931 ENSMUST00000194686.2 Gm37931 (from geneSymbol) ENSMUST00000194686.1 LF192719 uc287jed.1 uc287jed.2 uc287jed.1 uc287jed.2 
ENSMUST00000194687.2 Gm20807 ENSMUST00000194687.2 Belongs to the SPIN/STSY family. (from UniProt A0A0A6YXX7) A0A0A6YXX7 A0A0A6YXX7_MOUSE ENSMUST00000194687.1 Gm20807 Gm20833 uc292sgt.1 uc292sgt.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sgt.1 uc292sgt.2 
ENSMUST00000194690.6 Ddr2 ENSMUST00000194690.6 Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up- regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. (from UniProt Q62371) B2RSD7 DDR2_MOUSE ENSMUST00000194690.1 ENSMUST00000194690.2 ENSMUST00000194690.3 ENSMUST00000194690.4 ENSMUST00000194690.5 Ntrkr3 Q62371 Tkt Tyro10 X76505 uc007dlu.1 uc007dlu.2 uc007dlu.3 uc007dlu.4 Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up- regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=; Present in an inactive state in the absence of collagen binding and phosphorylation by SRC. Tyrosine phosphorylation enhances the affinity for ATP and the catalytic activity. Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1. Cell membrane; Single-pass type I membrane protein. Widely expressed. Detected in lung, ovary, skin and in testis Leydig cells (at protein level). Widely expressed. Detected at high levels in heart, lung, skeletal muscle, central nervous system (CNS) and kidney, and at lower levels in brain and testis. Detected in chondrocytes in tibia growth plates of young mice. Up-regulated during osteoblast differentiation (in vitro). Up-regulated in cartilage from mice with osteoarthritis. N-glycosylated. Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC; this is required for activation and subsequent autophosphorylation on additional tyrosine residues (By similarity). Note=Defects in Ddr2 are the cause of the smallie (sli) phenotype. Smallie mice show distinct dwarfing, with reduced body mass and reduced bone mineral content. Mice also have mild craniofacial deformities, such as protuberant eyes and snub noses. Smallie mice have a reduced life span, with about half of them dying within 6 months. Matings between male and female smallie mice do not yield any offspring. The levels of circulating steroid hormones remain at a level corresponding to prepubertal wild-type mice. Adult testes exhibit much reduced numbers of spermatids with atrophy of spermatogonia, Sertoli and Leydig cells. Ovaries show an absence of corpora lutea. Mice are born at the expected Mendelian rate, but fail to thrive, resulting in much reduced adult body weight and dwarfing. They exhibit shortening of long bones, irregular growth of flat bones and a shortened snout. Young mice show shortened growth plates in long bones and impaired chondrocyte proliferation. Likewise, cultured fibroblasts from mutant mice show reduced proliferation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. According to PubMed:18483174 Ddr2 is required for male and female fertility, since smallie mice with a 150 kb deletion that extends into the Ddr2 gene are sterile. Smallie males have defects in spermatogenesis (PubMed:19681157). On the other hand, the fertility status of mice with a targeted disruption of the Ddr2 gene has not been mentioned (PubMed:11375938). Thus, the infertility of smallie mice may be due to some additional, not yet identified defect. Sequence=CAA54040.1; Type=Erroneous initiation; Evidence=; nucleotide binding ossification endochondral bone growth protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity collagen binding ATP binding plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation positive regulation of fibroblast migration actin cytoskeleton membrane integral component of membrane kinase activity phosphorylation apical plasma membrane transferase activity peptidyl-tyrosine phosphorylation collagen fibril organization regulation of bone mineralization biomineral tissue development regulation of tissue remodeling chondrocyte proliferation protein tyrosine kinase collagen receptor activity collagen-activated tyrosine kinase receptor signaling pathway receptor complex positive regulation of osteoblast differentiation positive regulation of protein kinase activity protein autophosphorylation positive regulation of fibroblast proliferation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of extracellular matrix disassembly uc007dlu.1 uc007dlu.2 uc007dlu.3 uc007dlu.4 
ENSMUST00000194697.2 Gm2065 ENSMUST00000194697.2 Gm2065 (from geneSymbol) ENSMUST00000194697.1 uc292jfh.1 uc292jfh.2 uc292jfh.1 uc292jfh.2 
ENSMUST00000194699.2 Gm37174 ENSMUST00000194699.2 Gm37174 (from geneSymbol) AK036292 ENSMUST00000194699.1 uc287lgh.1 uc287lgh.2 uc287lgh.1 uc287lgh.2 
ENSMUST00000194702.2 Gm37003 ENSMUST00000194702.2 Gm37003 (from geneSymbol) AK081654 ENSMUST00000194702.1 uc291dsq.1 uc291dsq.2 uc291dsq.1 uc291dsq.2 
ENSMUST00000194704.2 Gm36987 ENSMUST00000194704.2 Gm36987 (from geneSymbol) ENSMUST00000194704.1 uc292sin.1 uc292sin.2 uc292sin.1 uc292sin.2 
ENSMUST00000194706.3 Gm7292 ENSMUST00000194706.3 Gm7292 (from geneSymbol) AK016198 ENSMUST00000194706.1 ENSMUST00000194706.2 uc291iep.1 uc291iep.2 uc291iep.3 uc291iep.1 uc291iep.2 uc291iep.3 
ENSMUST00000194707.4 Flg2 ENSMUST00000194707.4 filaggrin family member 2 (from RefSeq NM_001013804.2) ENSMUST00000194707.1 ENSMUST00000194707.2 ENSMUST00000194707.3 NM_001013804 uc290hfj.1 uc290hfj.2 uc290hfj.3 uc290hfj.1 uc290hfj.2 uc290hfj.3 
ENSMUST00000194708.2 Gm36948 ENSMUST00000194708.2 Gm36948 (from geneSymbol) ENSMUST00000194708.1 uc292iqg.1 uc292iqg.2 uc292iqg.1 uc292iqg.2 
ENSMUST00000194709.2 Gm36947 ENSMUST00000194709.2 Gm36947 (from geneSymbol) AK153594 ENSMUST00000194709.1 uc287gou.1 uc287gou.2 uc287gou.1 uc287gou.2 
ENSMUST00000194710.2 Gm37536 ENSMUST00000194710.2 Gm37536 (from geneSymbol) ENSMUST00000194710.1 uc287hsf.1 uc287hsf.2 uc287hsf.1 uc287hsf.2 
ENSMUST00000194711.2 Gm37917 ENSMUST00000194711.2 Gm37917 (from geneSymbol) AK189919 ENSMUST00000194711.1 uc292jxj.1 uc292jxj.2 uc292jxj.1 uc292jxj.2 
ENSMUST00000194712.2 Gm37577 ENSMUST00000194712.2 Gm37577 (from geneSymbol) ENSMUST00000194712.1 uc292sjj.1 uc292sjj.2 uc292sjj.1 uc292sjj.2 
ENSMUST00000194715.2 Gm38278 ENSMUST00000194715.2 Gm38278 (from geneSymbol) ENSMUST00000194715.1 uc287iqi.1 uc287iqi.2 uc287iqi.1 uc287iqi.2 
ENSMUST00000194716.2 Gm37621 ENSMUST00000194716.2 Gm37621 (from geneSymbol) AK141832 ENSMUST00000194716.1 uc292kbc.1 uc292kbc.2 uc292kbc.1 uc292kbc.2 
ENSMUST00000194718.2 Gm37451 ENSMUST00000194718.2 Gm37451 (from geneSymbol) ENSMUST00000194718.1 uc292src.1 uc292src.2 uc292src.1 uc292src.2 
ENSMUST00000194722.2 Gm37849 ENSMUST00000194722.2 Gm37849 (from geneSymbol) ENSMUST00000194722.1 LF193084 uc287ouj.1 uc287ouj.2 uc287ouj.1 uc287ouj.2 
ENSMUST00000194723.2 Gm37014 ENSMUST00000194723.2 Gm37014 (from geneSymbol) AK029190 ENSMUST00000194723.1 uc287mbn.1 uc287mbn.2 uc287mbn.1 uc287mbn.2 
ENSMUST00000194726.2 Gm37760 ENSMUST00000194726.2 Gm37760 (from geneSymbol) AK040326 ENSMUST00000194726.1 uc287ikj.1 uc287ikj.2 uc287ikj.1 uc287ikj.2 
ENSMUST00000194727.6 Cep170 ENSMUST00000194727.6 centrosomal protein 170, transcript variant 3 (from RefSeq NM_001368873.1) CE170_MOUSE ENSMUST00000194727.1 ENSMUST00000194727.2 ENSMUST00000194727.3 ENSMUST00000194727.4 ENSMUST00000194727.5 Kiaa0470 NM_001368873 Q6A065 Q7TQD9 Q8BJW2 Q9D3Z0 uc287oer.1 uc287oer.2 Plays a role in microtubule organization. Required for centriole subdistal appendage assembly. Interacts with CCDC68 and CCDC120; leading to recruitment to centrosomes (By similarity). Interacts with PLK1 (By similarity). Interacts with NIN (PubMed:27565344). Interacts with FHDC1 (PubMed:29742020). Interacts with CCDC61 (By similarity). Interacts with TBK1; efficient complex formation may be dependent on the presence of CCDC61 (By similarity). Q6A065; Q9NRI5: DISC1; Xeno; NbExp=2; IntAct=EBI-2554140, EBI-529989; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle Note=Associated with the mature mother centriole. Associated with spindle microtubules during mitosis (By similarity). Localizes to the distal appendage region of the centriole (By similarity). Localizes at the centriole proximal ends (By similarity). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6A065-1; Sequence=Displayed; Name=2; IsoId=Q6A065-2; Sequence=VSP_024244, VSP_024245; Name=3; IsoId=Q6A065-3; Sequence=VSP_024243, VSP_024246; Phosphorylated; probably by PLK1. Belongs to the CEP170 family. protein binding cytoplasm centrosome centriole spindle cytosol cytoskeleton microtubule plasma membrane biological_process uc287oer.1 uc287oer.2 
ENSMUST00000194728.2 Gm37985 ENSMUST00000194728.2 Gm37985 (from geneSymbol) AB351420 ENSMUST00000194728.1 uc290lgg.1 uc290lgg.2 uc290lgg.1 uc290lgg.2 
ENSMUST00000194736.2 Gm37978 ENSMUST00000194736.2 Gm37978 (from geneSymbol) ENSMUST00000194736.1 LF195361 uc291czl.1 uc291czl.2 uc291czl.1 uc291czl.2 
ENSMUST00000194737.2 Gm38243 ENSMUST00000194737.2 Gm38243 (from geneSymbol) AK049918 ENSMUST00000194737.1 uc287guy.1 uc287guy.2 uc287guy.1 uc287guy.2 
ENSMUST00000194742.2 Gm37714 ENSMUST00000194742.2 Gm37714 (from geneSymbol) ENSMUST00000194742.1 uc292ljf.1 uc292ljf.2 uc292ljf.1 uc292ljf.2 
ENSMUST00000194744.2 Gm19552 ENSMUST00000194744.2 Gm19552 (from geneSymbol) AY512928 ENSMUST00000194744.1 uc287jrt.1 uc287jrt.2 uc287jrt.1 uc287jrt.2 
ENSMUST00000194752.2 1700045I11Rik ENSMUST00000194752.2 1700045I11Rik (from geneSymbol) AK006699 ENSMUST00000194752.1 uc290mam.1 uc290mam.2 uc290mam.1 uc290mam.2 
ENSMUST00000194755.2 Gm37386 ENSMUST00000194755.2 Gm37386 (from geneSymbol) ENSMUST00000194755.1 uc290lbt.1 uc290lbt.2 uc290lbt.1 uc290lbt.2 
ENSMUST00000194757.2 Gm37740 ENSMUST00000194757.2 Gm37740 (from geneSymbol) ENSMUST00000194757.1 uc292sma.1 uc292sma.2 uc292sma.1 uc292sma.2 
ENSMUST00000194758.2 Gm38083 ENSMUST00000194758.2 Gm38083 (from geneSymbol) ENSMUST00000194758.1 uc292ixe.1 uc292ixe.2 uc292ixe.1 uc292ixe.2 
ENSMUST00000194760.2 Gm38262 ENSMUST00000194760.2 Gm38262 (from geneSymbol) AK143459 ENSMUST00000194760.1 uc287loz.1 uc287loz.2 uc287loz.1 uc287loz.2 
ENSMUST00000194761.2 Gm37729 ENSMUST00000194761.2 Gm37729 (from geneSymbol) ENSMUST00000194761.1 LF226792 uc287nbd.1 uc287nbd.2 uc287nbd.1 uc287nbd.2 
ENSMUST00000194762.2 Gm37196 ENSMUST00000194762.2 Gm37196 (from geneSymbol) ENSMUST00000194762.1 uc287hxf.1 uc287hxf.2 uc287hxf.1 uc287hxf.2 
ENSMUST00000194763.2 Gm37562 ENSMUST00000194763.2 Gm37562 (from geneSymbol) AK139228 ENSMUST00000194763.1 uc292kcf.1 uc292kcf.2 uc292kcf.1 uc292kcf.2 
ENSMUST00000194765.2 C630004M23Rik ENSMUST00000194765.2 C630004M23Rik (from geneSymbol) AK049866 ENSMUST00000194765.1 uc289swx.1 uc289swx.2 uc289swx.1 uc289swx.2 
ENSMUST00000194767.2 Gm37468 ENSMUST00000194767.2 Gm37468 (from geneSymbol) AK089558 ENSMUST00000194767.1 uc290dyf.1 uc290dyf.2 uc290dyf.1 uc290dyf.2 
ENSMUST00000194770.2 Gm37910 ENSMUST00000194770.2 Gm37910 (from geneSymbol) ENSMUST00000194770.1 uc288whk.1 uc288whk.2 uc288whk.1 uc288whk.2 
ENSMUST00000194773.2 Gm37781 ENSMUST00000194773.2 Gm37781 (from geneSymbol) ENSMUST00000194773.1 uc287lhn.1 uc287lhn.2 uc287lhn.1 uc287lhn.2 
ENSMUST00000194775.2 Gm38136 ENSMUST00000194775.2 Gm38136 (from geneSymbol) ENSMUST00000194775.1 uc292sry.1 uc292sry.2 uc292sry.1 uc292sry.2 
ENSMUST00000194780.2 Gm6934 ENSMUST00000194780.2 Gm6934 (from geneSymbol) AK153670 ENSMUST00000194780.1 uc289lwf.1 uc289lwf.2 uc289lwf.1 uc289lwf.2 
ENSMUST00000194790.2 4921511E07Rik ENSMUST00000194790.2 4921511E07Rik (from geneSymbol) AK014867 ENSMUST00000194790.1 uc287grs.1 uc287grs.2 uc287grs.1 uc287grs.2 
ENSMUST00000194793.2 Gm37407 ENSMUST00000194793.2 Gm37407 (from geneSymbol) AK140819 ENSMUST00000194793.1 uc287lky.1 uc287lky.2 uc287lky.1 uc287lky.2 
ENSMUST00000194795.2 Gm37480 ENSMUST00000194795.2 Gm37480 (from geneSymbol) ENSMUST00000194795.1 uc290ecc.1 uc290ecc.2 uc290ecc.1 uc290ecc.2 
ENSMUST00000194799.6 Gm36941 ENSMUST00000194799.6 Gm36941 (from geneSymbol) ENSMUST00000194799.1 ENSMUST00000194799.2 ENSMUST00000194799.3 ENSMUST00000194799.4 ENSMUST00000194799.5 uc292skh.1 uc292skh.2 uc292skh.1 uc292skh.2 
ENSMUST00000194803.2 Gm38284 ENSMUST00000194803.2 Gm38284 (from geneSymbol) ENSMUST00000194803.1 uc287mjx.1 uc287mjx.2 uc287mjx.1 uc287mjx.2 
ENSMUST00000194804.2 Gm37080 ENSMUST00000194804.2 Gm37080 (from geneSymbol) ENSMUST00000194804.1 uc287mfa.1 uc287mfa.2 uc287mfa.1 uc287mfa.2 
ENSMUST00000194805.6 Gm37840 ENSMUST00000194805.6 Gm37840 (from geneSymbol) ENSMUST00000194805.1 ENSMUST00000194805.2 ENSMUST00000194805.3 ENSMUST00000194805.4 ENSMUST00000194805.5 uc292spe.1 uc292spe.2 uc292spe.1 uc292spe.2 
ENSMUST00000194811.3 5330439B14Rik ENSMUST00000194811.3 RIKEN cDNA 5330439B14 gene (from RefSeq NR_037679.1) ENSMUST00000194811.1 ENSMUST00000194811.2 NR_037679 uc009epq.1 uc009epq.2 uc009epq.3 uc009epq.1 uc009epq.2 uc009epq.3 
ENSMUST00000194812.2 Gm37474 ENSMUST00000194812.2 Gm37474 (from geneSymbol) ENSMUST00000194812.1 uc292fny.1 uc292fny.2 uc292fny.1 uc292fny.2 
ENSMUST00000194817.2 Gm38111 ENSMUST00000194817.2 Gm38111 (from geneSymbol) ENSMUST00000194817.1 uc292iol.1 uc292iol.2 uc292iol.1 uc292iol.2 
ENSMUST00000194820.2 Gm37205 ENSMUST00000194820.2 Gm37205 (from geneSymbol) ENSMUST00000194820.1 uc287iqg.1 uc287iqg.2 uc287iqg.1 uc287iqg.2 
ENSMUST00000194822.2 Gm38060 ENSMUST00000194822.2 Gm38060 (from geneSymbol) ENSMUST00000194822.1 uc287naq.1 uc287naq.2 uc287naq.1 uc287naq.2 
ENSMUST00000194826.3 Paupar ENSMUST00000194826.3 Pax6 upstream antisense RNA (from RefSeq NR_117095.1) ENSMUST00000194826.1 ENSMUST00000194826.2 NR_117095 uc056zoc.1 uc056zoc.2 uc056zoc.3 uc056zoc.1 uc056zoc.2 uc056zoc.3 
ENSMUST00000194827.2 Gm37048 ENSMUST00000194827.2 Gm37048 (from geneSymbol) AK149971 ENSMUST00000194827.1 uc287klf.1 uc287klf.2 uc287klf.1 uc287klf.2 
ENSMUST00000194830.2 Gm37513 ENSMUST00000194830.2 Gm37513 (from geneSymbol) AK076311 ENSMUST00000194830.1 uc288vkl.1 uc288vkl.2 uc288vkl.1 uc288vkl.2 
ENSMUST00000194837.2 Gm37371 ENSMUST00000194837.2 Gm37371 (from geneSymbol) AK197646 ENSMUST00000194837.1 uc287mhg.1 uc287mhg.2 uc287mhg.1 uc287mhg.2 
ENSMUST00000194838.2 Gm38316 ENSMUST00000194838.2 Gm38316 (from geneSymbol) ENSMUST00000194838.1 uc288toc.1 uc288toc.2 uc288toc.1 uc288toc.2 
ENSMUST00000194841.3 Gm2464 ENSMUST00000194841.3 Gm2464 (from geneSymbol) AK140446 ENSMUST00000194841.1 ENSMUST00000194841.2 uc008oqa.1 uc008oqa.2 uc008oqa.3 uc008oqa.4 uc008oqa.5 uc008oqa.6 uc008oqa.1 uc008oqa.2 uc008oqa.3 uc008oqa.4 uc008oqa.5 uc008oqa.6 
ENSMUST00000194845.2 Gm38005 ENSMUST00000194845.2 Gm38005 (from geneSymbol) AK150151 ENSMUST00000194845.1 uc287gmh.1 uc287gmh.2 uc287gmh.1 uc287gmh.2 
ENSMUST00000194850.2 Gm38264 ENSMUST00000194850.2 Gm38264 (from geneSymbol) ENSMUST00000194850.1 uc287gfr.1 uc287gfr.2 uc287gfr.1 uc287gfr.2 
ENSMUST00000194854.2 Gm38372 ENSMUST00000194854.2 Gm38372 (from geneSymbol) AK041094 ENSMUST00000194854.1 uc287gho.1 uc287gho.2 uc287gho.1 uc287gho.2 
ENSMUST00000194858.2 Gm19918 ENSMUST00000194858.2 Gm19918 (from geneSymbol) ENSMUST00000194858.1 uc287mvw.1 uc287mvw.2 uc287mvw.1 uc287mvw.2 
ENSMUST00000194859.2 Gm38390 ENSMUST00000194859.2 Gm38390 (from geneSymbol) ENSMUST00000194859.1 EU315690 uc292qkn.1 uc292qkn.2 uc292qkn.1 uc292qkn.2 
ENSMUST00000194862.3 Gm37179 ENSMUST00000194862.3 Gm37179 (from geneSymbol) AK050857 ENSMUST00000194862.1 ENSMUST00000194862.2 uc288bqd.1 uc288bqd.2 uc288bqd.3 uc288bqd.1 uc288bqd.2 uc288bqd.3 
ENSMUST00000194865.2 Ighv1-47 ENSMUST00000194865.2 Ighv1-47 (from geneSymbol) A0A0A6YY41 A0A0A6YY41_MOUSE ENSMUST00000194865.1 Ighv1-47 X14623 uc288jzs.1 uc288jzs.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jzs.1 uc288jzs.2 
ENSMUST00000194866.2 Gm37412 ENSMUST00000194866.2 Gm37412 (from geneSymbol) ENSMUST00000194866.1 uc287gpj.1 uc287gpj.2 uc287gpj.1 uc287gpj.2 
ENSMUST00000194867.2 Gm37509 ENSMUST00000194867.2 Gm37509 (from geneSymbol) ENSMUST00000194867.1 LF192573 uc287gpx.1 uc287gpx.2 uc287gpx.1 uc287gpx.2 
ENSMUST00000194871.2 Gm37257 ENSMUST00000194871.2 Gm37257 (from geneSymbol) ENSMUST00000194871.1 uc288tax.1 uc288tax.2 uc288tax.1 uc288tax.2 
ENSMUST00000194879.2 Gm37782 ENSMUST00000194879.2 Gm37782 (from geneSymbol) ENSMUST00000194879.1 uc287skd.1 uc287skd.2 uc287skd.1 uc287skd.2 
ENSMUST00000194880.2 Gm37673 ENSMUST00000194880.2 Gm37673 (from geneSymbol) ENSMUST00000194880.1 LF195429 uc291dsn.1 uc291dsn.2 uc291dsn.1 uc291dsn.2 
ENSMUST00000194882.2 Gm37032 ENSMUST00000194882.2 Gm37032 (from geneSymbol) ENSMUST00000194882.1 uc292tfl.1 uc292tfl.2 uc292tfl.1 uc292tfl.2 
ENSMUST00000194883.2 Gm37520 ENSMUST00000194883.2 Gm37520 (from geneSymbol) ENSMUST00000194883.1 uc289szr.1 uc289szr.2 uc289szr.1 uc289szr.2 
ENSMUST00000194884.2 Gm38009 ENSMUST00000194884.2 Gm38009 (from geneSymbol) ENSMUST00000194884.1 LF192922 uc287mpz.1 uc287mpz.2 uc287mpz.1 uc287mpz.2 
ENSMUST00000194885.2 Gm37389 ENSMUST00000194885.2 Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (from UniProt A0A0A6YW05) A0A0A6YW05 A0A0A6YW05_MOUSE AK030155 ENSMUST00000194885.1 Gm37389 uc290dvf.1 uc290dvf.2 Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. lipid binding uc290dvf.1 uc290dvf.2 
ENSMUST00000194886.2 Gm30414 ENSMUST00000194886.2 Gm30414 (from geneSymbol) AK036865 ENSMUST00000194886.1 uc287ghz.1 uc287ghz.2 uc287ghz.1 uc287ghz.2 
ENSMUST00000194889.2 Gm36939 ENSMUST00000194889.2 Gm36939 (from geneSymbol) ENSMUST00000194889.1 uc289ern.1 uc289ern.2 uc289ern.1 uc289ern.2 
ENSMUST00000194891.2 Gm37391 ENSMUST00000194891.2 Gm37391 (from geneSymbol) ENSMUST00000194891.1 uc288ayq.1 uc288ayq.2 uc288ayq.1 uc288ayq.2 
ENSMUST00000194892.2 Gm5099 ENSMUST00000194892.2 predicted gene 5099 (from RefSeq NR_151587.1) ENSMUST00000194892.1 NR_151587 uc287hmu.1 uc287hmu.2 uc287hmu.1 uc287hmu.2 
ENSMUST00000194893.2 C230085N15Rik ENSMUST00000194893.2 C230085N15Rik (from geneSymbol) ENSMUST00000194893.1 uc289lvv.1 uc289lvv.2 uc289lvv.1 uc289lvv.2 
ENSMUST00000194899.2 Gm37482 ENSMUST00000194899.2 Gm37482 (from geneSymbol) ENSMUST00000194899.1 uc290kue.1 uc290kue.2 uc290kue.1 uc290kue.2 
ENSMUST00000194907.2 Gm37711 ENSMUST00000194907.2 Gm37711 (from geneSymbol) ENSMUST00000194907.1 uc290qjr.1 uc290qjr.2 uc290qjr.1 uc290qjr.2 
ENSMUST00000194910.2 Gm38255 ENSMUST00000194910.2 Gm38255 (from geneSymbol) ENSMUST00000194910.1 uc287kzl.1 uc287kzl.2 uc287kzl.1 uc287kzl.2 
ENSMUST00000194911.2 Gm37863 ENSMUST00000194911.2 Gm37863 (from geneSymbol) AK157502 ENSMUST00000194911.1 uc287idb.1 uc287idb.2 uc287idb.1 uc287idb.2 
ENSMUST00000194916.2 Gm37264 ENSMUST00000194916.2 Gm37264 (from geneSymbol) ENSMUST00000194916.1 LF192733 uc287jmb.1 uc287jmb.2 uc287jmb.1 uc287jmb.2 
ENSMUST00000194918.6 Olah ENSMUST00000194918.6 Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16). (from UniProt Q8R197) AK136031 ENSMUST00000194918.1 ENSMUST00000194918.2 ENSMUST00000194918.3 ENSMUST00000194918.4 ENSMUST00000194918.5 Olah Q3UWY0 Q8R197 SAST_MOUSE Thedc1 uc008idu.1 uc008idu.2 uc008idu.3 uc008idu.4 Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16). Reaction=(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP]; Xref=Rhea:RHEA:15057, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:9924, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:64479, ChEBI:CHEBI:78783; EC=3.1.2.14; Evidence=; Reaction=decanoyl-CoA + H2O = CoA + decanoate + H(+); Xref=Rhea:RHEA:40059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40060; Evidence=; Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence=; Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=; Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence=; Interacts (via C-terminus) with FASN. Cytoplasm, cytosol Belongs to the thioesterase family. oleoyl-[acyl-carrier-protein] hydrolase activity cellular_component cytoplasm cytosol lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process lipid biosynthetic process biosynthetic process myristoyl-[acyl-carrier-protein] hydrolase activity palmitoyl-[acyl-carrier-protein] hydrolase activity acyl-[acyl-carrier-protein] hydrolase activity hydrolase activity hydrolase activity, acting on ester bonds dodecanoyl-[acyl-carrier-protein] hydrolase activity medium-chain fatty acid biosynthetic process uc008idu.1 uc008idu.2 uc008idu.3 uc008idu.4 
ENSMUST00000194919.2 Gm37250 ENSMUST00000194919.2 Gm37250 (from geneSymbol) ENSMUST00000194919.1 uc287kpr.1 uc287kpr.2 uc287kpr.1 uc287kpr.2 
ENSMUST00000194920.2 A930005N03Rik ENSMUST00000194920.2 A930005N03Rik (from geneSymbol) ENSMUST00000194920.1 uc287hdj.1 uc287hdj.2 uc287hdj.1 uc287hdj.2 
ENSMUST00000194923.2 Gm36952 ENSMUST00000194923.2 Gm36952 (from geneSymbol) ENSMUST00000194923.1 uc287gyk.1 uc287gyk.2 uc287gyk.1 uc287gyk.2 
ENSMUST00000194925.2 Gm37607 ENSMUST00000194925.2 Gm37607 (from geneSymbol) AK142453 ENSMUST00000194925.1 uc287iie.1 uc287iie.2 uc287iie.1 uc287iie.2 
ENSMUST00000194927.2 Gm37215 ENSMUST00000194927.2 Gm37215 (from geneSymbol) AK081812 ENSMUST00000194927.1 uc287nah.1 uc287nah.2 uc287nah.1 uc287nah.2 
ENSMUST00000194928.2 Pcdhgb7 ENSMUST00000194928.2 protocadherin gamma subfamily B, 7 (from RefSeq NM_033579.2) ENSMUST00000194928.1 NM_033579 Pcdhgb7 Q91XX3 Q91XX3_MOUSE uc008era.1 uc008era.2 uc008era.3 uc008era.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane metal ion binding uc008era.1 uc008era.2 uc008era.3 uc008era.4 
ENSMUST00000194929.2 Gm37052 ENSMUST00000194929.2 Gm37052 (from geneSymbol) AK033103 ENSMUST00000194929.1 uc287nat.1 uc287nat.2 uc287nat.1 uc287nat.2 
ENSMUST00000194930.2 Gm37518 ENSMUST00000194930.2 Gm37518 (from geneSymbol) AK157072 ENSMUST00000194930.1 uc291uxc.1 uc291uxc.2 uc291uxc.1 uc291uxc.2 
ENSMUST00000194934.2 Gm38308 ENSMUST00000194934.2 Gm38308 (from geneSymbol) ENSMUST00000194934.1 uc287lsr.1 uc287lsr.2 uc287lsr.1 uc287lsr.2 
ENSMUST00000194937.2 9430092D12Rik ENSMUST00000194937.2 9430092D12Rik (from geneSymbol) ENSMUST00000194937.1 uc289fou.1 uc289fou.2 uc289fou.1 uc289fou.2 
ENSMUST00000194938.2 Gm31748 ENSMUST00000194938.2 Gm31748 (from geneSymbol) AK146199 ENSMUST00000194938.1 uc288vji.1 uc288vji.2 uc288vji.1 uc288vji.2 
ENSMUST00000194945.2 Gm36933 ENSMUST00000194945.2 Gm36933 (from geneSymbol) AK037326 ENSMUST00000194945.1 uc287okm.1 uc287okm.2 uc287okm.1 uc287okm.2 
ENSMUST00000194946.2 Gm37167 ENSMUST00000194946.2 Gm37167 (from geneSymbol) AK197646 ENSMUST00000194946.1 uc292foh.1 uc292foh.2 uc292foh.1 uc292foh.2 
ENSMUST00000194949.6 Gm36345 ENSMUST00000194949.6 Gm36345 (from geneSymbol) ENSMUST00000194949.1 ENSMUST00000194949.2 ENSMUST00000194949.3 ENSMUST00000194949.4 ENSMUST00000194949.5 uc292spu.1 uc292spu.2 uc292spu.1 uc292spu.2 
ENSMUST00000194951.3 Serpinb10 ENSMUST00000194951.3 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10, transcript variant 1 (from RefSeq NM_198028.3) ENSMUST00000194951.1 ENSMUST00000194951.2 NM_198028 uc287kyh.1 uc287kyh.2 uc287kyh.3 uc287kyh.1 uc287kyh.2 uc287kyh.3 
ENSMUST00000194952.2 Gm37818 ENSMUST00000194952.2 Gm37818 (from geneSymbol) AK052491 ENSMUST00000194952.1 uc287wue.1 uc287wue.2 uc287wue.1 uc287wue.2 
ENSMUST00000194954.3 Gm37374 ENSMUST00000194954.3 Gm37374 (from geneSymbol) ENSMUST00000194954.1 ENSMUST00000194954.2 uc292jkc.1 uc292jkc.2 uc292jkc.3 uc292jkc.1 uc292jkc.2 uc292jkc.3 
ENSMUST00000194955.2 5730408A14Rik ENSMUST00000194955.2 5730408A14Rik (from geneSymbol) ENSMUST00000194955.1 uc287odb.1 uc287odb.2 uc287odb.1 uc287odb.2 
ENSMUST00000194956.2 5430420F09Rik ENSMUST00000194956.2 5430420F09Rik (from geneSymbol) ENSMUST00000194956.1 uc290fej.1 uc290fej.2 uc290fej.1 uc290fej.2 
ENSMUST00000194957.2 Gm9874 ENSMUST00000194957.2 Gm9874 (from geneSymbol) ENSMUST00000194957.1 uc289jnf.1 uc289jnf.2 uc289jnf.1 uc289jnf.2 
ENSMUST00000194958.2 Gm37995 ENSMUST00000194958.2 Gm37995 (from geneSymbol) AK048071 ENSMUST00000194958.1 uc291dsm.1 uc291dsm.2 uc291dsm.1 uc291dsm.2 
ENSMUST00000194959.6 Usp4 ENSMUST00000194959.6 ubiquitin specific peptidase 4 (proto-oncogene), transcript variant 2 (from RefSeq NM_001311157.1) A0A0A6YW28 A0A0A6YW28_MOUSE ENSMUST00000194959.1 ENSMUST00000194959.2 ENSMUST00000194959.3 ENSMUST00000194959.4 ENSMUST00000194959.5 NM_001311157 Usp4 uc009rpi.1 uc009rpi.2 uc009rpi.3 uc009rpi.4 uc009rpi.5 Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence= Cytoplasm Belongs to the peptidase C19 family. USP4 subfamily. thiol-dependent ubiquitin-specific protease activity proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity uc009rpi.1 uc009rpi.2 uc009rpi.3 uc009rpi.4 uc009rpi.5 
ENSMUST00000194962.2 Gm37178 ENSMUST00000194962.2 Gm37178 (from geneSymbol) AK080518 ENSMUST00000194962.1 uc287owc.1 uc287owc.2 uc287owc.1 uc287owc.2 
ENSMUST00000194966.2 2900035J10Rik ENSMUST00000194966.2 2900035J10Rik (from geneSymbol) ENSMUST00000194966.1 uc287pdy.1 uc287pdy.2 uc287pdy.1 uc287pdy.2 
ENSMUST00000194968.6 Ighv1-20 ENSMUST00000194968.6 Ighv1-20 (from geneSymbol) A0A0A6YX66 A0A0A6YX66_MOUSE ENSMUST00000194968.1 ENSMUST00000194968.2 ENSMUST00000194968.3 ENSMUST00000194968.4 ENSMUST00000194968.5 Ighv1-20 uc288jyj.1 uc288jyj.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jyj.1 uc288jyj.2 
ENSMUST00000194969.2 Gm37625 ENSMUST00000194969.2 Gm37625 (from geneSymbol) DQ710151 ENSMUST00000194969.1 uc287lkm.1 uc287lkm.2 uc287lkm.1 uc287lkm.2 
ENSMUST00000194970.3 Gm37883 ENSMUST00000194970.3 Gm37883 (from geneSymbol) AK052574 ENSMUST00000194970.1 ENSMUST00000194970.2 uc291chs.1 uc291chs.2 uc291chs.1 uc291chs.2 
ENSMUST00000194973.2 Gm37871 ENSMUST00000194973.2 Gm37871 (from geneSymbol) ENSMUST00000194973.1 uc292iwm.1 uc292iwm.2 uc292iwm.1 uc292iwm.2 
ENSMUST00000194987.2 Gm38273 ENSMUST00000194987.2 Gm38273 (from geneSymbol) ENSMUST00000194987.1 uc289tfv.1 uc289tfv.2 uc289tfv.1 uc289tfv.2 
ENSMUST00000194988.2 4930500M09Rik ENSMUST00000194988.2 4930500M09Rik (from geneSymbol) AK015669 ENSMUST00000194988.1 uc287npr.1 uc287npr.2 uc287npr.1 uc287npr.2 
ENSMUST00000194989.2 Gm37761 ENSMUST00000194989.2 Gm37761 (from geneSymbol) ENSMUST00000194989.1 uc287krp.1 uc287krp.2 uc287krp.1 uc287krp.2 
ENSMUST00000194990.2 Gm38123 ENSMUST00000194990.2 Gm38123 (from geneSymbol) ENSMUST00000194990.1 uc288jnd.1 uc288jnd.2 uc288jnd.1 uc288jnd.2 
ENSMUST00000194991.2 Gm37012 ENSMUST00000194991.2 Gm37012 (from geneSymbol) ENSMUST00000194991.1 uc292jjt.1 uc292jjt.2 uc292jjt.1 uc292jjt.2 
ENSMUST00000194994.2 Gm37309 ENSMUST00000194994.2 Gm37309 (from geneSymbol) AK052113 ENSMUST00000194994.1 uc287hnt.1 uc287hnt.2 uc287hnt.1 uc287hnt.2 
ENSMUST00000194996.2 Gm37865 ENSMUST00000194996.2 Gm37865 (from geneSymbol) ENSMUST00000194996.1 uc292skf.1 uc292skf.2 uc292skf.1 uc292skf.2 
ENSMUST00000194997.2 Gm37060 ENSMUST00000194997.2 Gm37060 (from geneSymbol) ENSMUST00000194997.1 uc287mwz.1 uc287mwz.2 uc287mwz.1 uc287mwz.2 
ENSMUST00000194998.2 Gm37802 ENSMUST00000194998.2 Gm37802 (from geneSymbol) AK143363 ENSMUST00000194998.1 uc287mwg.1 uc287mwg.2 uc287mwg.1 uc287mwg.2 
ENSMUST00000194999.2 Gm37987 ENSMUST00000194999.2 Gm37987 (from geneSymbol) AK080552 ENSMUST00000194999.1 uc292jqe.1 uc292jqe.2 uc292jqe.1 uc292jqe.2 
ENSMUST00000195000.2 Gm37564 ENSMUST00000195000.2 Gm37564 (from geneSymbol) ENSMUST00000195000.1 uc292nxy.1 uc292nxy.2 uc292nxy.1 uc292nxy.2 
ENSMUST00000195003.2 Gm37813 ENSMUST00000195003.2 Gm37813 (from geneSymbol) ENSMUST00000195003.1 uc290dwo.1 uc290dwo.2 uc290dwo.1 uc290dwo.2 
ENSMUST00000195012.2 A730013G03Rik ENSMUST00000195012.2 RIKEN cDNA A730013G03 gene (from RefSeq NR_155503.1) ENSMUST00000195012.1 NR_155503 uc287pbn.1 uc287pbn.2 uc287pbn.1 uc287pbn.2 
ENSMUST00000195013.2 Gm37737 ENSMUST00000195013.2 Gm37737 (from geneSymbol) AK148345 ENSMUST00000195013.1 uc287ilr.1 uc287ilr.2 uc287ilr.1 uc287ilr.2 
ENSMUST00000195014.6 Ssr2 ENSMUST00000195014.6 signal sequence receptor, beta, transcript variant 4 (from RefSeq NM_001356318.1) ENSMUST00000195014.1 ENSMUST00000195014.2 ENSMUST00000195014.3 ENSMUST00000195014.4 ENSMUST00000195014.5 NM_001356318 Q91Z43 Q9CPW5 Q9CR94 Q9CX54 SSRB_MOUSE uc008pvs.1 uc008pvs.2 uc008pvs.3 TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP- gamma. Interacts with STING1 (By similarity). Endoplasmic reticulum membrane ; Single-pass type I membrane protein Belongs to the TRAP-beta family. in utero embryonic development molecular_function endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane uc008pvs.1 uc008pvs.2 uc008pvs.3 
ENSMUST00000195015.6 Tmco1 ENSMUST00000195015.6 transmembrane and coiled-coil domains 1 (from RefSeq NM_001039483.1) ENSMUST00000195015.1 ENSMUST00000195015.2 ENSMUST00000195015.3 ENSMUST00000195015.4 ENSMUST00000195015.5 NM_001039483 Q3TS11 Q921L3 TMCO1_MOUSE Tmco1 uc007dkv.1 uc007dkv.2 uc007dkv.3 Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum (ER) overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (PubMed:27212239). Component of the multi- pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (By similarity). Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload. Component of the GET- and EMC-like (GEL) complex, composed of RAB5IF/OPTI and TMCO1. The GEL complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Note=The first transmembrane region is required for localization to the endoplasmic reticulum. Mice are born at a much lower rate than predicted by the Mendelian ratio. Surviving mice show a reduced body size, low survival rate and delayed osteogenesis. Adult mice display craniofacial dysmorphism such as open cranial sutures, flattened faces with shorten nasal bones and skull anomalies. Moreover, magnetic resonance imaging (MRI) of brain shows significantly enlarged brain ventricles. Adult mice show defects in spatial recognition memory in a Y-maze task assay and a significant deficiency in motor coordination in rotarod assessments. Defects are probably due to calcium overload, calcium imaging results revealing a significant overload of endoplasmic reticulum calcium in osteoblasts. Belongs to the TMCO1 family. Golgi membrane calcium channel activity endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus ion transport calcium ion transport ER overload response membrane integral component of membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum calcium ion homeostasis calcium ion transmembrane transport uc007dkv.1 uc007dkv.2 uc007dkv.3 
ENSMUST00000195020.6 Gm37687 ENSMUST00000195020.6 Gm37687 (from geneSymbol) ENSMUST00000195020.1 ENSMUST00000195020.2 ENSMUST00000195020.3 ENSMUST00000195020.4 ENSMUST00000195020.5 uc292spn.1 uc292spn.2 uc292spn.1 uc292spn.2 
ENSMUST00000195024.2 Gm37588 ENSMUST00000195024.2 Gm37588 (from geneSymbol) ENSMUST00000195024.1 LF192845 uc287lkt.1 uc287lkt.2 uc287lkt.1 uc287lkt.2 
ENSMUST00000195025.2 Gm37728 ENSMUST00000195025.2 Gm37728 (from geneSymbol) AK053950 ENSMUST00000195025.1 uc291dhb.1 uc291dhb.2 uc291dhb.1 uc291dhb.2 
ENSMUST00000195028.2 Gm37062 ENSMUST00000195028.2 Gm37062 (from geneSymbol) ENSMUST00000195028.1 uc287hmp.1 uc287hmp.2 uc287hmp.1 uc287hmp.2 
ENSMUST00000195029.6 Gm38363 ENSMUST00000195029.6 Gm38363 (from geneSymbol) ENSMUST00000195029.1 ENSMUST00000195029.2 ENSMUST00000195029.3 ENSMUST00000195029.4 ENSMUST00000195029.5 uc292sif.1 uc292sif.2 uc292sif.1 uc292sif.2 
ENSMUST00000195037.2 Ighv8-2 ENSMUST00000195037.2 Ighv8-2 (from geneSymbol) A0A0A6YW58 A0A0A6YW58_MOUSE ENSMUST00000195037.1 Ighv8-2 uc288jxa.1 uc288jxa.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jxa.1 uc288jxa.2 
ENSMUST00000195039.2 Gm38340 ENSMUST00000195039.2 Gm38340 (from geneSymbol) ENSMUST00000195039.1 uc291ope.1 uc291ope.2 uc291ope.1 uc291ope.2 
ENSMUST00000195048.2 Gm37571 ENSMUST00000195048.2 Gm37571 (from geneSymbol) ENSMUST00000195048.1 uc287mtr.1 uc287mtr.2 uc287mtr.1 uc287mtr.2 
ENSMUST00000195050.2 Gm37809 ENSMUST00000195050.2 Gm37809 (from geneSymbol) AK148684 ENSMUST00000195050.1 uc287nau.1 uc287nau.2 uc287nau.1 uc287nau.2 
ENSMUST00000195052.2 Gm38032 ENSMUST00000195052.2 Gm38032 (from geneSymbol) ENSMUST00000195052.1 uc292kft.1 uc292kft.2 uc292kft.1 uc292kft.2 
ENSMUST00000195053.2 Gm38321 ENSMUST00000195053.2 Gm38321 (from geneSymbol) ENSMUST00000195053.1 LF192526 uc291xma.1 uc291xma.2 uc291xma.1 uc291xma.2 
ENSMUST00000195063.2 Gm37252 ENSMUST00000195063.2 Gm37252 (from geneSymbol) ENSMUST00000195063.1 uc292sha.1 uc292sha.2 uc292sha.1 uc292sha.2 
ENSMUST00000195064.2 4930518J20Rik ENSMUST00000195064.2 4930518J20Rik (from geneSymbol) AK015829 ENSMUST00000195064.1 uc057avq.1 uc057avq.2 uc057avq.3 uc057avq.1 uc057avq.2 uc057avq.3 
ENSMUST00000195065.2 Gm37114 ENSMUST00000195065.2 Gm37114 (from geneSymbol) ENSMUST00000195065.1 uc287jrq.1 uc287jrq.2 uc287jrq.1 uc287jrq.2 
ENSMUST00000195066.2 Gm37061 ENSMUST00000195066.2 Gm37061 (from geneSymbol) AK052349 ENSMUST00000195066.1 uc287iys.1 uc287iys.2 uc287iys.1 uc287iys.2 
ENSMUST00000195074.2 Gm37709 ENSMUST00000195074.2 Gm37709 (from geneSymbol) ENSMUST00000195074.1 uc289fqv.1 uc289fqv.2 uc289fqv.1 uc289fqv.2 
ENSMUST00000195079.2 Gm37473 ENSMUST00000195079.2 Gm37473 (from geneSymbol) ENSMUST00000195079.1 uc292skt.1 uc292skt.2 uc292skt.1 uc292skt.2 
ENSMUST00000195087.2 Trbv21 ENSMUST00000195087.2 Trbv21 (from geneSymbol) A0A0A6YX06 A0A0A6YX06_MOUSE ENSMUST00000195087.1 Trbv21 uc291dup.1 uc291dup.2 uc291dup.1 uc291dup.2 
ENSMUST00000195090.2 Gm36997 ENSMUST00000195090.2 Gm36997 (from geneSymbol) ENSMUST00000195090.1 uc287uqv.1 uc287uqv.2 uc287uqv.1 uc287uqv.2 
ENSMUST00000195097.2 Gm37148 ENSMUST00000195097.2 Gm37148 (from geneSymbol) ENSMUST00000195097.1 uc289nvr.1 uc289nvr.2 uc289nvr.1 uc289nvr.2 
ENSMUST00000195098.2 Gm37955 ENSMUST00000195098.2 Gm37955 (from geneSymbol) ENSMUST00000195098.1 LF204658 uc292irq.1 uc292irq.2 uc292irq.1 uc292irq.2 
ENSMUST00000195109.2 Gm38133 ENSMUST00000195109.2 Gm38133 (from geneSymbol) ENSMUST00000195109.1 uc288ppz.1 uc288ppz.2 uc288ppz.1 uc288ppz.2 
ENSMUST00000195110.2 Gm38240 ENSMUST00000195110.2 Gm38240 (from geneSymbol) ENSMUST00000195110.1 uc287lly.1 uc287lly.2 uc287lly.1 uc287lly.2 
ENSMUST00000195112.2 Pcdhgb2 ENSMUST00000195112.2 protocadherin gamma subfamily B, 2 (from RefSeq NM_033575.4) ENSMUST00000195112.1 NM_033575 Pcdhgb2 Q91XX7 Q91XX7_MOUSE uc008eqq.1 uc008eqq.2 uc008eqq.3 uc008eqq.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding protein binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane metal ion binding uc008eqq.1 uc008eqq.2 uc008eqq.3 uc008eqq.4 
ENSMUST00000195116.2 Gm37929 ENSMUST00000195116.2 Gm37929 (from geneSymbol) AK138475 ENSMUST00000195116.1 uc287ovl.1 uc287ovl.2 uc287ovl.1 uc287ovl.2 
ENSMUST00000195117.2 Atf3 ENSMUST00000195117.2 This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters (PubMed:11916968). Represses transcription from promoters with ATF sites (PubMed:11916968). It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity). (from UniProt Q60765) AB291912 ATF3_MOUSE Atf3 ENSMUST00000195117.1 Q60765 uc011wyt.1 uc011wyt.2 uc011wyt.3 This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters (PubMed:11916968). Represses transcription from promoters with ATF sites (PubMed:11916968). It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity). Binds DNA as a homodimer or a heterodimer. Interacts with KAT5; promoting KAT5 autoacetylation and KAT5 deubiquitination by USP7. Nucleus By stress. Belongs to the bZIP family. ATF subfamily. negative regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleolus gluconeogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of cell proliferation positive regulation of gene expression endoplasmic reticulum unfolded protein response cellular response to amino acid starvation skeletal muscle cell differentiation identical protein binding protein homodimerization activity transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity negative regulation of ERK1 and ERK2 cascade positive regulation of TRAIL-activated apoptotic signaling pathway positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress CHOP-ATF3 complex uc011wyt.1 uc011wyt.2 uc011wyt.3 
ENSMUST00000195118.2 Gm37393 ENSMUST00000195118.2 Gm37393 (from geneSymbol) ENSMUST00000195118.1 uc287hwy.1 uc287hwy.2 uc287hwy.1 uc287hwy.2 
ENSMUST00000195121.2 Gm38104 ENSMUST00000195121.2 Gm38104 (from geneSymbol) ENSMUST00000195121.1 LF193032 uc287oez.1 uc287oez.2 uc287oez.1 uc287oez.2 
ENSMUST00000195122.2 Gm38297 ENSMUST00000195122.2 Gm38297 (from geneSymbol) ENSMUST00000195122.1 uc292kal.1 uc292kal.2 uc292kal.1 uc292kal.2 
ENSMUST00000195124.6 Ighv3-6 ENSMUST00000195124.6 Ighv3-6 (from geneSymbol) ENSMUST00000195124.1 ENSMUST00000195124.2 ENSMUST00000195124.3 ENSMUST00000195124.4 ENSMUST00000195124.5 Gm16932 HVM60_MOUSE M19895 P18531 uc288jwh.1 uc288jwh.2 adaptive immune response immune system process antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin complex immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jwh.1 uc288jwh.2 
ENSMUST00000195128.2 Gm38286 ENSMUST00000195128.2 Gm38286 (from geneSymbol) AK048426 ENSMUST00000195128.1 uc287gxx.1 uc287gxx.2 uc287gxx.1 uc287gxx.2 
ENSMUST00000195131.2 Gm37968 ENSMUST00000195131.2 Gm37968 (from geneSymbol) ENSMUST00000195131.1 uc290fcz.1 uc290fcz.2 uc290fcz.1 uc290fcz.2 
ENSMUST00000195132.2 Gm37273 ENSMUST00000195132.2 Gm37273 (from geneSymbol) ENSMUST00000195132.1 uc287ngw.1 uc287ngw.2 uc287ngw.1 uc287ngw.2 
ENSMUST00000195134.2 Gm37915 ENSMUST00000195134.2 Gm37915 (from geneSymbol) AK036610 ENSMUST00000195134.1 uc287hqh.1 uc287hqh.2 uc287hqh.1 uc287hqh.2 
ENSMUST00000195137.2 Gm37245 ENSMUST00000195137.2 Gm37245 (from geneSymbol) AK144002 ENSMUST00000195137.1 uc290hfy.1 uc290hfy.2 uc290hfy.1 uc290hfy.2 
ENSMUST00000195138.2 Gm37137 ENSMUST00000195138.2 Gm37137 (from geneSymbol) ENSMUST00000195138.1 uc292iot.1 uc292iot.2 uc292iot.1 uc292iot.2 
ENSMUST00000195141.2 Gm38073 ENSMUST00000195141.2 Gm38073 (from geneSymbol) ENSMUST00000195141.1 uc287lhv.1 uc287lhv.2 uc287lhv.1 uc287lhv.2 
ENSMUST00000195145.2 1700040K01Rik ENSMUST00000195145.2 1700040K01Rik (from geneSymbol) AK006660 ENSMUST00000195145.1 uc287mpj.1 uc287mpj.2 uc287mpj.1 uc287mpj.2 
ENSMUST00000195146.2 Gm38221 ENSMUST00000195146.2 Gm38221 (from geneSymbol) ENSMUST00000195146.1 uc290beh.1 uc290beh.2 uc290beh.1 uc290beh.2 
ENSMUST00000195147.2 Gm32444 ENSMUST00000195147.2 Gm32444 (from geneSymbol) AK051587 ENSMUST00000195147.1 uc290jcg.1 uc290jcg.2 uc290jcg.1 uc290jcg.2 
ENSMUST00000195148.3 Gm33973 ENSMUST00000195148.3 Gm33973 (from geneSymbol) ENSMUST00000195148.1 ENSMUST00000195148.2 uc287orn.1 uc287orn.2 uc287orn.3 uc287orn.1 uc287orn.2 uc287orn.3 
ENSMUST00000195152.2 Gm36929 ENSMUST00000195152.2 Gm36929 (from geneSymbol) ENSMUST00000195152.1 uc292smk.1 uc292smk.2 uc292smk.1 uc292smk.2 
ENSMUST00000195153.2 Gm38378 ENSMUST00000195153.2 Gm38378 (from geneSymbol) AK076311 ENSMUST00000195153.1 uc288vjx.1 uc288vjx.2 uc288vjx.1 uc288vjx.2 
ENSMUST00000195166.2 Gm38148 ENSMUST00000195166.2 Gm38148 (from geneSymbol) AK140620 ENSMUST00000195166.1 uc287gdl.1 uc287gdl.2 uc287gdl.1 uc287gdl.2 
ENSMUST00000195171.2 Gm37235 ENSMUST00000195171.2 Gm37235 (from geneSymbol) AJ002202 ENSMUST00000195171.1 uc291xmb.1 uc291xmb.2 uc291xmb.1 uc291xmb.2 
ENSMUST00000195172.2 Gm38277 ENSMUST00000195172.2 Gm38277 (from geneSymbol) ENSMUST00000195172.1 uc287khr.1 uc287khr.2 uc287khr.1 uc287khr.2 
ENSMUST00000195173.2 4930566N20Rik ENSMUST00000195173.2 4930566N20Rik (from geneSymbol) ENSMUST00000195173.1 uc290kvb.1 uc290kvb.2 uc290kvb.1 uc290kvb.2 
ENSMUST00000195178.2 Gm37999 ENSMUST00000195178.2 Gm37999 (from geneSymbol) AK046227 ENSMUST00000195178.1 uc287hba.1 uc287hba.2 uc287hba.1 uc287hba.2 
ENSMUST00000195179.2 Gm37220 ENSMUST00000195179.2 Gm37220 (from geneSymbol) ENSMUST00000195179.1 uc289yvk.1 uc289yvk.2 uc289yvk.1 uc289yvk.2 
ENSMUST00000195180.2 Gm37143 ENSMUST00000195180.2 Gm37143 (from geneSymbol) ENSMUST00000195180.1 uc287giz.1 uc287giz.2 uc287giz.1 uc287giz.2 
ENSMUST00000195185.2 Gm37249 ENSMUST00000195185.2 Gm37249 (from geneSymbol) ENSMUST00000195185.1 uc292jyg.1 uc292jyg.2 uc292jyg.1 uc292jyg.2 
ENSMUST00000195186.2 Gm34550 ENSMUST00000195186.2 Gm34550 (from geneSymbol) ENSMUST00000195186.1 uc292slj.1 uc292slj.2 uc292slj.1 uc292slj.2 
ENSMUST00000195187.2 Gm37602 ENSMUST00000195187.2 Gm37602 (from geneSymbol) ENSMUST00000195187.1 uc287gyl.1 uc287gyl.2 uc287gyl.1 uc287gyl.2 
ENSMUST00000195188.6 Gm33954 ENSMUST00000195188.6 Gm33954 (from geneSymbol) ENSMUST00000195188.1 ENSMUST00000195188.2 ENSMUST00000195188.3 ENSMUST00000195188.4 ENSMUST00000195188.5 uc292soj.1 uc292soj.2 uc292soj.1 uc292soj.2 
ENSMUST00000195198.6 Gm31422 ENSMUST00000195198.6 Gm31422 (from geneSymbol) ENSMUST00000195198.1 ENSMUST00000195198.2 ENSMUST00000195198.3 ENSMUST00000195198.4 ENSMUST00000195198.5 uc292srn.1 uc292srn.2 uc292srn.1 uc292srn.2 
ENSMUST00000195202.2 Gm37989 ENSMUST00000195202.2 Gm37989 (from geneSymbol) AK156496 ENSMUST00000195202.1 uc287jub.1 uc287jub.2 uc287jub.1 uc287jub.2 
ENSMUST00000195204.2 Gm38234 ENSMUST00000195204.2 Gm38234 (from geneSymbol) ENSMUST00000195204.1 uc288xek.1 uc288xek.2 uc288xek.1 uc288xek.2 
ENSMUST00000195205.2 Gm38296 ENSMUST00000195205.2 Gm38296 (from geneSymbol) ENSMUST00000195205.1 uc292spq.1 uc292spq.2 uc292spq.1 uc292spq.2 
ENSMUST00000195208.2 Gm37956 ENSMUST00000195208.2 Gm37956 (from geneSymbol) ENSMUST00000195208.1 uc292pxv.1 uc292pxv.2 uc292pxv.1 uc292pxv.2 
ENSMUST00000195210.2 Gm38093 ENSMUST00000195210.2 Gm38093 (from geneSymbol) ENSMUST00000195210.1 uc287otv.1 uc287otv.2 uc287otv.1 uc287otv.2 
ENSMUST00000195213.2 Gm37843 ENSMUST00000195213.2 Gm37843 (from geneSymbol) ENSMUST00000195213.1 uc290fbp.1 uc290fbp.2 uc290fbp.1 uc290fbp.2 
ENSMUST00000195215.2 Gm37477 ENSMUST00000195215.2 Gm37477 (from geneSymbol) ENSMUST00000195215.1 uc292jqb.1 uc292jqb.2 uc292jqb.1 uc292jqb.2 
ENSMUST00000195216.2 Gm37812 ENSMUST00000195216.2 Gm37812 (from geneSymbol) AK047028 ENSMUST00000195216.1 uc292jpn.1 uc292jpn.2 uc292jpn.1 uc292jpn.2 
ENSMUST00000195221.2 Gm37561 ENSMUST00000195221.2 Gm37561 (from geneSymbol) ENSMUST00000195221.1 uc292shs.1 uc292shs.2 uc292shs.1 uc292shs.2 
ENSMUST00000195223.2 Gm37385 ENSMUST00000195223.2 Gm37385 (from geneSymbol) AK197646 ENSMUST00000195223.1 uc287hdo.1 uc287hdo.2 uc287hdo.1 uc287hdo.2 
ENSMUST00000195224.2 Gm37399 ENSMUST00000195224.2 Gm37399 (from geneSymbol) AK085860 ENSMUST00000195224.1 uc290fce.1 uc290fce.2 uc290fce.1 uc290fce.2 
ENSMUST00000195226.2 Gm36932 ENSMUST00000195226.2 Gm36932 (from geneSymbol) AK079677 ENSMUST00000195226.1 uc289szq.1 uc289szq.2 uc289szq.1 uc289szq.2 
ENSMUST00000195234.2 Tcstv7a ENSMUST00000195234.2 Tcstv family member 7A (from RefSeq NM_001001449.3) AF067063 ENSMUST00000195234.1 NM_001001449 O70618 O70618_MOUSE uc029sdn.1 uc029sdn.2 uc029sdn.3 uc029sdn.1 uc029sdn.2 uc029sdn.3 
ENSMUST00000195237.2 Gm37310 ENSMUST00000195237.2 Gm37310 (from geneSymbol) AK080909 ENSMUST00000195237.1 uc288wwn.1 uc288wwn.2 uc288wwn.1 uc288wwn.2 
ENSMUST00000195240.2 Gm37724 ENSMUST00000195240.2 Gm37724 (from geneSymbol) ENSMUST00000195240.1 LF244356 uc287hbj.1 uc287hbj.2 uc287hbj.1 uc287hbj.2 
ENSMUST00000195241.2 Gm37426 ENSMUST00000195241.2 Gm37426 (from geneSymbol) AK033926 ENSMUST00000195241.1 uc287hbf.1 uc287hbf.2 uc287hbf.1 uc287hbf.2 
ENSMUST00000195243.2 Gm37359 ENSMUST00000195243.2 Gm37359 (from geneSymbol) AK144610 ENSMUST00000195243.1 uc008pkt.1 uc008pkt.2 uc008pkt.1 uc008pkt.2 
ENSMUST00000195244.2 Gm36971 ENSMUST00000195244.2 Gm36971 (from geneSymbol) ENSMUST00000195244.1 uc288gfm.1 uc288gfm.2 uc288gfm.1 uc288gfm.2 
ENSMUST00000195250.2 Gm37611 ENSMUST00000195250.2 Gm37611 (from geneSymbol) AK036163 ENSMUST00000195250.1 uc292ith.1 uc292ith.2 uc292ith.1 uc292ith.2 
ENSMUST00000195252.2 Gm9839 ENSMUST00000195252.2 Gm9839 (from geneSymbol) ENSMUST00000195252.1 uc011wiv.1 uc011wiv.2 uc011wiv.3 uc011wiv.1 uc011wiv.2 uc011wiv.3 
ENSMUST00000195253.2 Gm37006 ENSMUST00000195253.2 Gm37006 (from geneSymbol) AK034833 ENSMUST00000195253.1 uc289tfu.1 uc289tfu.2 uc289tfu.1 uc289tfu.2 
ENSMUST00000195266.2 Gm37017 ENSMUST00000195266.2 Gm37017 (from geneSymbol) ENSMUST00000195266.1 uc287kbq.1 uc287kbq.2 uc287kbq.1 uc287kbq.2 
ENSMUST00000195272.6 Cnga3 ENSMUST00000195272.6 cyclic nucleotide gated channel alpha 3, transcript variant 1 (from RefSeq NM_001282010.2) A0A0A6YXW9 A0A0A6YXW9_MOUSE Cnga3 ENSMUST00000195272.1 ENSMUST00000195272.2 ENSMUST00000195272.3 ENSMUST00000195272.4 ENSMUST00000195272.5 NM_001282010 uc287hkd.1 uc287hkd.2 Membrane ; Multi- pass membrane protein ion channel activity intracellular cGMP activated cation channel activity cytoplasm plasma membrane ion transport cation transport protein C-terminus binding membrane integral component of membrane dendrite cGMP binding response to corticosteroid response to magnesium ion ion transmembrane transport neuronal cell body axon initial segment perikaryon response to cAMP transmembrane transport glial cell projection inorganic cation import into cell transmembrane transporter complex uc287hkd.1 uc287hkd.2 
ENSMUST00000195276.2 Gm37817 ENSMUST00000195276.2 Gm37817 (from geneSymbol) ENSMUST00000195276.1 LF194587 uc290pkt.1 uc290pkt.2 uc290pkt.1 uc290pkt.2 
ENSMUST00000195278.2 2210017I01Rik ENSMUST00000195278.2 Belongs to the LCE family. (from UniProt A0A0A6YVV1) 2210017I01Rik A0A0A6YVV1 A0A0A6YVV1_MOUSE AK131883 ENSMUST00000195278.1 uc290het.1 uc290het.2 Belongs to the LCE family. molecular_function cellular_component biological_process epidermis development uc290het.1 uc290het.2 
ENSMUST00000195279.3 4930562F17Rik ENSMUST00000195279.3 4930562F17Rik (from geneSymbol) AK016192 ENSMUST00000195279.1 ENSMUST00000195279.2 uc007ddy.1 uc007ddy.2 uc007ddy.3 uc007ddy.4 uc007ddy.1 uc007ddy.2 uc007ddy.3 uc007ddy.4 
ENSMUST00000195280.3 Kantr ENSMUST00000195280.3 Kdm5c adjacent non-coding transcript, transcript variant 2 (from RefSeq NR_040270.2) A0A1W2P7I0 ENSMUST00000195280.1 ENSMUST00000195280.2 KANTR_MOUSE Kantr NR_040270 Spasm uc292rgk.1 uc292rgk.2 This gene is thought to produce a functional long non-coding RNA. Mutation of this locus causes tremors and spastic movements, suggesting a role for this gene in neurological development or function. [provided by RefSeq, Feb 2015]. Membrane ; Single-pass type I membrane protein Homozygous mice have tremors and a propensity to develop spastic movements upon handling. membrane integral component of membrane uc292rgk.1 uc292rgk.2 
ENSMUST00000195282.2 Gm37830 ENSMUST00000195282.2 Gm37830 (from geneSymbol) ENSMUST00000195282.1 uc288ppc.1 uc288ppc.2 uc288ppc.1 uc288ppc.2 
ENSMUST00000195284.2 Gm19721 ENSMUST00000195284.2 Gm19721 (from geneSymbol) AK149799 ENSMUST00000195284.1 uc292kwl.1 uc292kwl.2 uc292kwl.1 uc292kwl.2 
ENSMUST00000195287.2 Gm4081 ENSMUST00000195287.2 Gm4081 (from geneSymbol) AK044004 ENSMUST00000195287.1 uc287iga.1 uc287iga.2 uc287iga.1 uc287iga.2 
ENSMUST00000195288.2 Gm37848 ENSMUST00000195288.2 Gm37848 (from geneSymbol) ENSMUST00000195288.1 uc287mxu.1 uc287mxu.2 uc287mxu.1 uc287mxu.2 
ENSMUST00000195289.2 Gm37126 ENSMUST00000195289.2 Gm37126 (from geneSymbol) AK005721 ENSMUST00000195289.1 uc289ter.1 uc289ter.2 uc289ter.1 uc289ter.2 
ENSMUST00000195290.2 Gm37652 ENSMUST00000195290.2 Gm37652 (from geneSymbol) AK084499 ENSMUST00000195290.1 uc290ehf.1 uc290ehf.2 uc290ehf.1 uc290ehf.2 
ENSMUST00000195293.2 Gm37953 ENSMUST00000195293.2 Gm37953 (from geneSymbol) AK139467 ENSMUST00000195293.1 uc292kbe.1 uc292kbe.2 uc292kbe.1 uc292kbe.2 
ENSMUST00000195297.2 Gm38126 ENSMUST00000195297.2 Gm38126 (from geneSymbol) ENSMUST00000195297.1 uc287nao.1 uc287nao.2 uc287nao.1 uc287nao.2 
ENSMUST00000195301.2 Gm37993 ENSMUST00000195301.2 Gm37993 (from geneSymbol) ENSMUST00000195301.1 uc292jmq.1 uc292jmq.2 uc292jmq.1 uc292jmq.2 
ENSMUST00000195303.3 Gm37020 ENSMUST00000195303.3 Gm37020 (from geneSymbol) ENSMUST00000195303.1 ENSMUST00000195303.2 uc287hjx.1 uc287hjx.2 uc287hjx.3 uc287hjx.1 uc287hjx.2 uc287hjx.3 
ENSMUST00000195304.2 Gm37965 ENSMUST00000195304.2 Gm37965 (from geneSymbol) ENSMUST00000195304.1 uc290egg.1 uc290egg.2 uc290egg.1 uc290egg.2 
ENSMUST00000195306.2 Gm38344 ENSMUST00000195306.2 Gm38344 (from geneSymbol) ENSMUST00000195306.1 uc292kbf.1 uc292kbf.2 uc292kbf.1 uc292kbf.2 
ENSMUST00000195308.2 Gm37864 ENSMUST00000195308.2 Gm37864 (from geneSymbol) AK029708 ENSMUST00000195308.1 uc287nkb.1 uc287nkb.2 uc287nkb.1 uc287nkb.2 
ENSMUST00000195309.2 Gm37707 ENSMUST00000195309.2 Gm37707 (from geneSymbol) ENSMUST00000195309.1 uc287hnm.1 uc287hnm.2 uc287hnm.1 uc287hnm.2 
ENSMUST00000195310.2 Gm37905 ENSMUST00000195310.2 Gm37905 (from geneSymbol) BC119469 ENSMUST00000195310.1 uc287hcg.1 uc287hcg.2 uc287hcg.1 uc287hcg.2 
ENSMUST00000195313.2 Gm37122 ENSMUST00000195313.2 Gm37122 (from geneSymbol) AK043481 ENSMUST00000195313.1 uc288oia.1 uc288oia.2 uc288oia.1 uc288oia.2 
ENSMUST00000195317.2 Gm37914 ENSMUST00000195317.2 Gm37914 (from geneSymbol) ENSMUST00000195317.1 LF228749 uc287jzg.1 uc287jzg.2 uc287jzg.1 uc287jzg.2 
ENSMUST00000195320.2 Gm36986 ENSMUST00000195320.2 Gm36986 (from geneSymbol) ENSMUST00000195320.1 uc287ift.1 uc287ift.2 uc287ift.1 uc287ift.2 
ENSMUST00000195321.2 Gm38172 ENSMUST00000195321.2 Gm38172 (from geneSymbol) ENSMUST00000195321.1 uc288gqj.1 uc288gqj.2 uc288gqj.1 uc288gqj.2 
ENSMUST00000195326.2 Gm37107 ENSMUST00000195326.2 Gm37107 (from geneSymbol) ENSMUST00000195326.1 uc289srn.1 uc289srn.2 uc289srn.1 uc289srn.2 
ENSMUST00000195327.2 Gm37796 ENSMUST00000195327.2 Gm37796 (from geneSymbol) DQ703304 ENSMUST00000195327.1 uc287mhq.1 uc287mhq.2 uc287mhq.1 uc287mhq.2 
ENSMUST00000195328.2 Gm38039 ENSMUST00000195328.2 Gm38039 (from geneSymbol) ENSMUST00000195328.1 uc287mzf.1 uc287mzf.2 uc287mzf.1 uc287mzf.2 
ENSMUST00000195331.2 Gm10305 ENSMUST00000195331.2 Gm10305 (from geneSymbol) ENSMUST00000195331.1 uc290nzu.1 uc290nzu.2 uc290nzu.1 uc290nzu.2 
ENSMUST00000195332.2 Gm37420 ENSMUST00000195332.2 Gm37420 (from geneSymbol) ENSMUST00000195332.1 LF200008 uc288vbe.1 uc288vbe.2 uc288vbe.1 uc288vbe.2 
ENSMUST00000195335.2 Gm37180 ENSMUST00000195335.2 Gm37180 (from geneSymbol) ENSMUST00000195335.1 uc287gdf.1 uc287gdf.2 uc287gdf.1 uc287gdf.2 
ENSMUST00000195337.2 Ighv15-2 ENSMUST00000195337.2 Ighv15-2 (from geneSymbol) A0A0A6YX72 A0A0A6YX72_MOUSE ENSMUST00000195337.1 Ighv15-2 uc288jxo.1 uc288jxo.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jxo.1 uc288jxo.2 
ENSMUST00000195338.2 A530064N14Rik ENSMUST00000195338.2 A530064N14Rik (from geneSymbol) AK080119 ENSMUST00000195338.1 uc292iro.1 uc292iro.2 uc292iro.1 uc292iro.2 
ENSMUST00000195343.2 Gm10857 ENSMUST00000195343.2 predicted gene 10857, transcript variant 2 (from RefSeq NR_033471.1) ENSMUST00000195343.1 NR_033471 uc012boz.1 uc012boz.2 uc012boz.3 uc012boz.1 uc012boz.2 uc012boz.3 
ENSMUST00000195348.2 A430050A11Rik ENSMUST00000195348.2 A430050A11Rik (from geneSymbol) ENSMUST00000195348.1 uc287mur.1 uc287mur.2 uc287mur.1 uc287mur.2 
ENSMUST00000195349.2 Gm37886 ENSMUST00000195349.2 Gm37886 (from geneSymbol) ENSMUST00000195349.1 uc287jph.1 uc287jph.2 uc287jph.1 uc287jph.2 
ENSMUST00000195351.2 Gm37963 ENSMUST00000195351.2 Gm37963 (from geneSymbol) ENSMUST00000195351.1 uc292ldn.1 uc292ldn.2 uc292ldn.1 uc292ldn.2 
ENSMUST00000195352.2 Gm37925 ENSMUST00000195352.2 Gm37925 (from geneSymbol) AK048198 ENSMUST00000195352.1 uc287jur.1 uc287jur.2 uc287jur.1 uc287jur.2 
ENSMUST00000195353.2 Gm38055 ENSMUST00000195353.2 Gm38055 (from geneSymbol) ENSMUST00000195353.1 LF193913 uc290fef.1 uc290fef.2 uc290fef.1 uc290fef.2 
ENSMUST00000195354.6 Syt14 ENSMUST00000195354.6 synaptotagmin XIV, transcript variant 2 (from RefSeq NM_181546.3) ENSMUST00000195354.1 ENSMUST00000195354.2 ENSMUST00000195354.3 ENSMUST00000195354.4 ENSMUST00000195354.5 NM_181546 Q7TN84 SYT14_MOUSE uc007edu.1 uc007edu.2 uc007edu.3 uc007edu.4 This gene encodes a member of the synaptotagmin family. The encoded protein may be involved in membrane trafficking. Disruption of a similar gene in human has been associated with autosomal recessive spinocerebellar ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent. Homodimer. Can also form heterodimers (By similarity). Membrane ; Single-pass type III membrane protein Expressed in heart and testis. Expressed in brain (especially in the cerebellum). Belongs to the synaptotagmin family. phospholipid binding membrane integral component of membrane protein homodimerization activity protein heterodimerization activity calcium-dependent phospholipid binding uc007edu.1 uc007edu.2 uc007edu.3 uc007edu.4 
ENSMUST00000195357.2 Gm38341 ENSMUST00000195357.2 Gm38341 (from geneSymbol) ENSMUST00000195357.1 uc288xfr.1 uc288xfr.2 uc288xfr.1 uc288xfr.2 
ENSMUST00000195359.6 Ighv1-59 ENSMUST00000195359.6 Ighv1-59 (from geneSymbol) A0A0A6YXE0 A0A0A6YXE0_MOUSE AF045500 ENSMUST00000195359.1 ENSMUST00000195359.2 ENSMUST00000195359.3 ENSMUST00000195359.4 ENSMUST00000195359.5 Ighv1-59 uc288kau.1 uc288kau.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kau.1 uc288kau.2 
ENSMUST00000195360.2 Gm38069 ENSMUST00000195360.2 Gm38069 (from geneSymbol) AK048073 ENSMUST00000195360.1 uc287gng.1 uc287gng.2 uc287gng.1 uc287gng.2 
ENSMUST00000195362.2 Gm36954 ENSMUST00000195362.2 Gm36954 (from geneSymbol) ENSMUST00000195362.1 uc287wqa.1 uc287wqa.2 uc287wqa.1 uc287wqa.2 
ENSMUST00000195363.2 Pcdhgb4 ENSMUST00000195363.2 protocadherin gamma subfamily B, 4 (from RefSeq NM_033576.2) ENSMUST00000195363.1 NM_033576 Pcdhgb4 Q91XX6 Q91XX6_MOUSE uc008equ.1 uc008equ.2 uc008equ.3 uc008equ.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding protein binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008equ.1 uc008equ.2 uc008equ.3 uc008equ.4 
ENSMUST00000195366.2 Gm10723 ENSMUST00000195366.2 predicted gene 10723 (from RefSeq NR_189030.1) ENSMUST00000195366.1 NR_189030 uc290fux.1 uc290fux.2 uc290fux.1 uc290fux.2 
ENSMUST00000195368.2 2810405F15Rik ENSMUST00000195368.2 2810405F15Rik (from geneSymbol) AK012992 ENSMUST00000195368.1 uc012cbg.1 uc012cbg.2 uc012cbg.3 uc012cbg.1 uc012cbg.2 uc012cbg.3 
ENSMUST00000195369.2 Gm37643 ENSMUST00000195369.2 Gm37643 (from geneSymbol) AK089389 ENSMUST00000195369.1 uc289pka.1 uc289pka.2 uc289pka.1 uc289pka.2 
ENSMUST00000195371.6 Gm30686 ENSMUST00000195371.6 Gm30686 (from geneSymbol) ENSMUST00000195371.1 ENSMUST00000195371.2 ENSMUST00000195371.3 ENSMUST00000195371.4 ENSMUST00000195371.5 uc292sil.1 uc292sil.2 uc292sil.1 uc292sil.2 
ENSMUST00000195372.2 Disp1 ENSMUST00000195372.2 dispatched RND transporter family member 1, transcript variant 2 (from RefSeq NM_001278218.1) DISP1_MOUSE Disp Dispa ENSMUST00000195372.1 Icb Icbins NM_001278218 Q3TDN0 Q3UUL8 Q80ZZ8 Q8CGS3 Q8CIP6 Q8CIQ9 Q9CT62 uc008icm.1 uc008icm.2 uc008icm.3 Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404). Interacts with SHH; via the cholesterol anchor of the dually lipid-modified SHH (ShhNp) (PubMed:22902404). Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TDN0-1; Sequence=Displayed; Name=2; IsoId=Q3TDN0-2; Sequence=VSP_029322, VSP_029323; Expression overlaps with the one of SHH and IHH being restricted to tissues that require Hh signaling. PubMed:12372301, reported a more ubiquitous expression which is detected throughout the embryo at 7.5 dpc and is maintained during embryonic development. Death at or soon after 9.5 dpc probably due to abnormal embryonic turning and looping of the heart. Embryos also display defects in development of the forebrain and branchial arches. Belongs to the dispatched family. patched ligand maturation multicellular organism development determination of left/right symmetry embryonic pattern specification dorsal/ventral pattern formation peptide transport membrane integral component of membrane diaphragm development peptide transmembrane transporter activity uc008icm.1 uc008icm.2 uc008icm.3 
ENSMUST00000195375.2 Gm31942 ENSMUST00000195375.2 Gm31942 (from geneSymbol) ENSMUST00000195375.1 uc292sjc.1 uc292sjc.2 uc292sjc.1 uc292sjc.2 
ENSMUST00000195378.2 Gm37484 ENSMUST00000195378.2 Gm37484 (from geneSymbol) AK038581 ENSMUST00000195378.1 uc292jjc.1 uc292jjc.2 uc292jjc.1 uc292jjc.2 
ENSMUST00000195379.2 Gm37706 ENSMUST00000195379.2 Gm37706 (from geneSymbol) ENSMUST00000195379.1 LF204561 uc287ofv.1 uc287ofv.2 uc287ofv.1 uc287ofv.2 
ENSMUST00000195380.2 Gm37860 ENSMUST00000195380.2 Gm37860 (from geneSymbol) AK041561 ENSMUST00000195380.1 uc287nke.1 uc287nke.2 uc287nke.1 uc287nke.2 
ENSMUST00000195381.2 Ighv5-12-4 ENSMUST00000195381.2 Ighv5-12-4 (from geneSymbol) A0A0A6YWG4 A0A0A6YWG4_MOUSE ENSMUST00000195381.1 Ighv5-12-4 uc288jue.1 uc288jue.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jue.1 uc288jue.2 
ENSMUST00000195382.2 Gm38357 ENSMUST00000195382.2 Gm38357 (from geneSymbol) DQ550443 ENSMUST00000195382.1 uc290fbt.1 uc290fbt.2 uc290fbt.1 uc290fbt.2 
ENSMUST00000195385.2 Gm9910 ENSMUST00000195385.2 predicted gene 9910 (from RefSeq NR_188984.1) ENSMUST00000195385.1 NR_188984 uc288cye.1 uc288cye.2 uc288cye.1 uc288cye.2 
ENSMUST00000195386.2 Gm38109 ENSMUST00000195386.2 Gm38109 (from geneSymbol) AJ290944 ENSMUST00000195386.1 uc289nkp.1 uc289nkp.2 uc289nkp.1 uc289nkp.2 
ENSMUST00000195389.2 Gm38152 ENSMUST00000195389.2 Gm38152 (from geneSymbol) ENSMUST00000195389.1 uc287oem.1 uc287oem.2 uc287oem.1 uc287oem.2 
ENSMUST00000195395.7 ENSMUSG00000121419 ENSMUST00000195395.7 ENSMUSG00000121419 (from geneSymbol) ENSMUST00000195395.1 ENSMUST00000195395.2 ENSMUST00000195395.3 ENSMUST00000195395.4 ENSMUST00000195395.5 ENSMUST00000195395.6 uc290eiu.1 uc290eiu.2 uc290eiu.3 uc290eiu.1 uc290eiu.2 uc290eiu.3 
ENSMUST00000195397.2 9330162B11Rik ENSMUST00000195397.2 RIKEN cDNA 9330162B11 gene (from RefSeq NR_038007.1) ENSMUST00000195397.1 NR_038007 uc007eac.1 uc007eac.2 uc007eac.1 uc007eac.2 
ENSMUST00000195400.2 Gm37954 ENSMUST00000195400.2 Gm37954 (from geneSymbol) AK140805 ENSMUST00000195400.1 uc287lpb.1 uc287lpb.2 uc287lpb.1 uc287lpb.2 
ENSMUST00000195401.2 Gm37653 ENSMUST00000195401.2 Gm37653 (from geneSymbol) AK138050 ENSMUST00000195401.1 uc287nav.1 uc287nav.2 uc287nav.1 uc287nav.2 
ENSMUST00000195404.2 Gm38170 ENSMUST00000195404.2 Gm38170 (from geneSymbol) AK087391 ENSMUST00000195404.1 uc288hdr.1 uc288hdr.2 uc288hdr.1 uc288hdr.2 
ENSMUST00000195406.2 Gm1647 ENSMUST00000195406.2 predicted gene 1647 (from RefSeq NR_126533.1) ENSMUST00000195406.1 NR_126533 uc008pmf.1 uc008pmf.2 uc008pmf.3 uc008pmf.1 uc008pmf.2 uc008pmf.3 
ENSMUST00000195407.2 Gm37640 ENSMUST00000195407.2 Gm37640 (from geneSymbol) ENSMUST00000195407.1 uc290ekf.1 uc290ekf.2 uc290ekf.1 uc290ekf.2 
ENSMUST00000195409.2 Gm37289 ENSMUST00000195409.2 Gm37289 (from geneSymbol) AK044724 ENSMUST00000195409.1 uc289tcv.1 uc289tcv.2 uc289tcv.1 uc289tcv.2 
ENSMUST00000195411.2 Gm37570 ENSMUST00000195411.2 Gm37570 (from geneSymbol) AK039429 ENSMUST00000195411.1 uc287ixe.1 uc287ixe.2 uc287ixe.1 uc287ixe.2 
ENSMUST00000195413.2 Gm38384 ENSMUST00000195413.2 Gm38384 (from geneSymbol) ENSMUST00000195413.1 uc292cvt.1 uc292cvt.2 uc292cvt.1 uc292cvt.2 
ENSMUST00000195414.2 9430087J23Rik ENSMUST00000195414.2 9430087J23Rik (from geneSymbol) AK020511 ENSMUST00000195414.1 uc287nad.1 uc287nad.2 uc287nad.1 uc287nad.2 
ENSMUST00000195416.2 Gm37894 ENSMUST00000195416.2 Gm37894 (from geneSymbol) AK157621 ENSMUST00000195416.1 uc289teu.1 uc289teu.2 uc289teu.1 uc289teu.2 
ENSMUST00000195417.2 Ighv1-43 ENSMUST00000195417.2 Ighv1-43 (from geneSymbol) A0A0A6YXN5 A0A0A6YXN5_MOUSE AJ251890 ENSMUST00000195417.1 Ighv1-43 uc288jzn.1 uc288jzn.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jzn.1 uc288jzn.2 
ENSMUST00000195425.2 Gm37657 ENSMUST00000195425.2 Gm37657 (from geneSymbol) ENSMUST00000195425.1 uc292sny.1 uc292sny.2 uc292sny.1 uc292sny.2 
ENSMUST00000195426.2 Gm38312 ENSMUST00000195426.2 Gm38312 (from geneSymbol) AK142592 ENSMUST00000195426.1 uc287kgs.1 uc287kgs.2 uc287kgs.1 uc287kgs.2 
ENSMUST00000195431.2 Gm36930 ENSMUST00000195431.2 Gm36930 (from geneSymbol) ENSMUST00000195431.1 uc289tgl.1 uc289tgl.2 uc289tgl.1 uc289tgl.2 
ENSMUST00000195434.2 Gm37488 ENSMUST00000195434.2 Gm37488 (from geneSymbol) AK041681 ENSMUST00000195434.1 uc290foi.1 uc290foi.2 uc290foi.1 uc290foi.2 
ENSMUST00000195437.2 Gm37522 ENSMUST00000195437.2 Gm37522 (from geneSymbol) ENSMUST00000195437.1 LF192602 uc287gzu.1 uc287gzu.2 uc287gzu.1 uc287gzu.2 
ENSMUST00000195439.2 Gm37163 ENSMUST00000195439.2 Gm37163 (from geneSymbol) AK132997 ENSMUST00000195439.1 uc057avk.1 uc057avk.2 uc057avk.1 uc057avk.2 
ENSMUST00000195445.2 Gm37144 ENSMUST00000195445.2 Gm37144 (from geneSymbol) AK043653 ENSMUST00000195445.1 uc287gen.1 uc287gen.2 uc287gen.1 uc287gen.2 
ENSMUST00000195446.3 A830092H15Rik ENSMUST00000195446.3 A830092H15Rik (from geneSymbol) AK165771 ENSMUST00000195446.1 ENSMUST00000195446.2 uc290edt.1 uc290edt.2 uc290edt.3 uc290edt.1 uc290edt.2 uc290edt.3 
ENSMUST00000195448.2 Gm33354 ENSMUST00000195448.2 Gm33354 (from geneSymbol) ENSMUST00000195448.1 uc287nne.1 uc287nne.2 uc287nne.1 uc287nne.2 
ENSMUST00000195451.2 1700051O22Rik ENSMUST00000195451.2 1700051O22Rik (from geneSymbol) AK006764 ENSMUST00000195451.1 uc292btg.1 uc292btg.2 uc292btg.1 uc292btg.2 
ENSMUST00000195453.6 Gm38013 ENSMUST00000195453.6 Gm38013 (from geneSymbol) ENSMUST00000195453.1 ENSMUST00000195453.2 ENSMUST00000195453.3 ENSMUST00000195453.4 ENSMUST00000195453.5 uc292sld.1 uc292sld.2 uc292sld.1 uc292sld.2 
ENSMUST00000195455.2 Gm37091 ENSMUST00000195455.2 Gm37091 (from geneSymbol) DQ689458 ENSMUST00000195455.1 uc287hnw.1 uc287hnw.2 uc287hnw.1 uc287hnw.2 
ENSMUST00000195460.2 Gm37583 ENSMUST00000195460.2 Gm37583 (from geneSymbol) ENSMUST00000195460.1 uc290qzk.1 uc290qzk.2 uc290qzk.1 uc290qzk.2 
ENSMUST00000195466.2 Gm38351 ENSMUST00000195466.2 Gm38351 (from geneSymbol) ENSMUST00000195466.1 uc287iqo.1 uc287iqo.2 uc287iqo.1 uc287iqo.2 
ENSMUST00000195468.6 Ighv5-2 ENSMUST00000195468.6 Ighv5-2 (from geneSymbol) A0A0A6YVX8 A0A0A6YVX8_MOUSE ENSMUST00000195468.1 ENSMUST00000195468.2 ENSMUST00000195468.3 ENSMUST00000195468.4 ENSMUST00000195468.5 Ighv5-2 uc288jte.1 uc288jte.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jte.1 uc288jte.2 
ENSMUST00000195469.6 Ighv1-12 ENSMUST00000195469.6 Ighv1-12 (from geneSymbol) A0A0A6YXJ9 A0A0A6YXJ9_MOUSE ENSMUST00000195469.1 ENSMUST00000195469.2 ENSMUST00000195469.3 ENSMUST00000195469.4 ENSMUST00000195469.5 Ighv1-12 M17953 uc288jxv.1 uc288jxv.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jxv.1 uc288jxv.2 
ENSMUST00000195470.2 Gm37924 ENSMUST00000195470.2 Gm37924 (from geneSymbol) AB350507 ENSMUST00000195470.1 uc290egc.1 uc290egc.2 uc290egc.1 uc290egc.2 
ENSMUST00000195473.2 Gm37166 ENSMUST00000195473.2 Gm37166 (from geneSymbol) AK082320 ENSMUST00000195473.1 uc292keg.1 uc292keg.2 uc292keg.1 uc292keg.2 
ENSMUST00000195475.2 Gm37109 ENSMUST00000195475.2 Gm37109 (from geneSymbol) AK033885 ENSMUST00000195475.1 uc287lmt.1 uc287lmt.2 uc287lmt.1 uc287lmt.2 
ENSMUST00000195476.2 Gm37821 ENSMUST00000195476.2 Gm37821 (from geneSymbol) AK029680 ENSMUST00000195476.1 uc287hnv.1 uc287hnv.2 uc287hnv.1 uc287hnv.2 
ENSMUST00000195478.2 Gm37733 ENSMUST00000195478.2 Gm37733 (from geneSymbol) ENSMUST00000195478.1 LF249210 uc287jfa.1 uc287jfa.2 uc287jfa.1 uc287jfa.2 
ENSMUST00000195479.2 Gm38339 ENSMUST00000195479.2 Gm38339 (from geneSymbol) AK149606 ENSMUST00000195479.1 uc287jqd.1 uc287jqd.2 uc287jqd.1 uc287jqd.2 
ENSMUST00000195486.6 Gm30353 ENSMUST00000195486.6 Gm30353 (from geneSymbol) ENSMUST00000195486.1 ENSMUST00000195486.2 ENSMUST00000195486.3 ENSMUST00000195486.4 ENSMUST00000195486.5 uc292sij.1 uc292sij.2 uc292sij.1 uc292sij.2 
ENSMUST00000195487.2 Gm37031 ENSMUST00000195487.2 Gm37031 (from geneSymbol) ENSMUST00000195487.1 uc290elj.1 uc290elj.2 uc290elj.1 uc290elj.2 
ENSMUST00000195490.6 Gm37344 ENSMUST00000195490.6 Gm37344 (from geneSymbol) ENSMUST00000195490.1 ENSMUST00000195490.2 ENSMUST00000195490.3 ENSMUST00000195490.4 ENSMUST00000195490.5 uc292six.1 uc292six.2 uc292six.1 uc292six.2 
ENSMUST00000195491.2 Gm36960 ENSMUST00000195491.2 Gm36960 (from geneSymbol) ENSMUST00000195491.1 uc292jpl.1 uc292jpl.2 uc292jpl.1 uc292jpl.2 
ENSMUST00000195493.2 Gm38376 ENSMUST00000195493.2 Gm38376 (from geneSymbol) AK034603 ENSMUST00000195493.1 uc287goe.1 uc287goe.2 uc287goe.1 uc287goe.2 
ENSMUST00000195494.2 Gm37975 ENSMUST00000195494.2 Gm37975 (from geneSymbol) ENSMUST00000195494.1 uc289taq.1 uc289taq.2 uc289taq.1 uc289taq.2 
ENSMUST00000195496.2 Gm37676 ENSMUST00000195496.2 Gm37676 (from geneSymbol) ENSMUST00000195496.1 uc287lqc.1 uc287lqc.2 uc287lqc.1 uc287lqc.2 
ENSMUST00000195497.3 Gm37720 ENSMUST00000195497.3 Gm37720 (from geneSymbol) AK041128 ENSMUST00000195497.1 ENSMUST00000195497.2 uc290vqs.1 uc290vqs.2 uc290vqs.1 uc290vqs.2 
ENSMUST00000195500.2 Gm36527 ENSMUST00000195500.2 Gm36527 (from geneSymbol) AK051329 ENSMUST00000195500.1 uc287mnt.1 uc287mnt.2 uc287mnt.1 uc287mnt.2 
ENSMUST00000195501.2 Gm38043 ENSMUST00000195501.2 Gm38043 (from geneSymbol) ENSMUST00000195501.1 uc287mvo.1 uc287mvo.2 uc287mvo.1 uc287mvo.2 
ENSMUST00000195506.2 Gm38120 ENSMUST00000195506.2 Gm38120 (from geneSymbol) ENSMUST00000195506.1 uc007ais.1 uc007ais.2 uc007ais.3 uc007ais.1 uc007ais.2 uc007ais.3 
ENSMUST00000195507.2 Gm37016 ENSMUST00000195507.2 Gm37016 (from geneSymbol) ENSMUST00000195507.1 uc289fzp.1 uc289fzp.2 uc289fzp.1 uc289fzp.2 
ENSMUST00000195509.2 4833412K13Rik ENSMUST00000195509.2 4833412K13Rik (from geneSymbol) AK014687 ENSMUST00000195509.1 uc287joi.1 uc287joi.2 uc287joi.1 uc287joi.2 
ENSMUST00000195510.2 Gm37900 ENSMUST00000195510.2 Gm37900 (from geneSymbol) ENSMUST00000195510.1 uc290llk.1 uc290llk.2 uc290llk.1 uc290llk.2 
ENSMUST00000195512.2 Gm37206 ENSMUST00000195512.2 Gm37206 (from geneSymbol) ENSMUST00000195512.1 LF201550 uc008gat.1 uc008gat.2 uc008gat.3 uc008gat.1 uc008gat.2 uc008gat.3 
ENSMUST00000195515.2 Crnn ENSMUST00000195515.2 cornulin (from RefSeq NM_001081200.2) Crnn D3YUU6 D3YUU6_MOUSE ENSMUST00000195515.1 NM_001081200 uc290hfg.1 uc290hfg.2 molecular_function calcium ion binding response to heat membrane metal ion binding transition metal ion binding cell-cell adhesion uc290hfg.1 uc290hfg.2 
ENSMUST00000195518.3 Gm15853 ENSMUST00000195518.3 Gm15853 (from geneSymbol) ENSMUST00000195518.1 ENSMUST00000195518.2 KY467519 uc057khg.1 uc057khg.2 uc057khg.3 uc057khg.1 uc057khg.2 uc057khg.3 
ENSMUST00000195528.2 Gm30238 ENSMUST00000195528.2 Gm30238 (from geneSymbol) ENSMUST00000195528.1 LF199355 uc288jnz.1 uc288jnz.2 uc288jnz.1 uc288jnz.2 
ENSMUST00000195529.2 Gm37859 ENSMUST00000195529.2 Gm37859 (from geneSymbol) AK083142 ENSMUST00000195529.1 uc290itc.1 uc290itc.2 uc290itc.1 uc290itc.2 
ENSMUST00000195532.2 Pisrt1 ENSMUST00000195532.2 Pisrt1 (from geneSymbol) AY572459 ENSMUST00000195532.1 uc292jxh.1 uc292jxh.2 uc292jxh.1 uc292jxh.2 
ENSMUST00000195535.2 Gm37962 ENSMUST00000195535.2 Gm37962 (from geneSymbol) AK047528 ENSMUST00000195535.1 uc292kbb.1 uc292kbb.2 uc292kbb.1 uc292kbb.2 
ENSMUST00000195540.2 Gm37637 ENSMUST00000195540.2 Gm37637 (from geneSymbol) ENSMUST00000195540.1 uc292jxe.1 uc292jxe.2 uc292jxe.1 uc292jxe.2 
ENSMUST00000195541.2 Gm37311 ENSMUST00000195541.2 Gm37311 (from geneSymbol) AK039359 ENSMUST00000195541.1 uc289fph.1 uc289fph.2 uc289fph.1 uc289fph.2 
ENSMUST00000195543.2 Gm37011 ENSMUST00000195543.2 Gm37011 (from geneSymbol) ENSMUST00000195543.1 uc287gyb.1 uc287gyb.2 uc287gyb.1 uc287gyb.2 
ENSMUST00000195546.2 Gm37777 ENSMUST00000195546.2 Gm37777 (from geneSymbol) ENSMUST00000195546.1 uc287mhc.1 uc287mhc.2 uc287mhc.1 uc287mhc.2 
ENSMUST00000195551.2 Gm38057 ENSMUST00000195551.2 Gm38057 (from geneSymbol) ENSMUST00000195551.1 uc292ioa.1 uc292ioa.2 uc292ioa.1 uc292ioa.2 
ENSMUST00000195552.2 Gm37238 ENSMUST00000195552.2 Gm37238 (from geneSymbol) ENSMUST00000195552.1 uc288mqm.1 uc288mqm.2 uc288mqm.1 uc288mqm.2 
ENSMUST00000195553.2 Gm37132 ENSMUST00000195553.2 Gm37132 (from geneSymbol) ENSMUST00000195553.1 uc287pep.1 uc287pep.2 uc287pep.1 uc287pep.2 
ENSMUST00000195556.2 Gm37551 ENSMUST00000195556.2 Gm37551 (from geneSymbol) ENSMUST00000195556.1 uc287lhu.1 uc287lhu.2 uc287lhu.1 uc287lhu.2 
ENSMUST00000195562.2 Gm38162 ENSMUST00000195562.2 Gm38162 (from geneSymbol) AK137498 ENSMUST00000195562.1 uc287ixg.1 uc287ixg.2 uc287ixg.1 uc287ixg.2 
ENSMUST00000195566.2 Gm37490 ENSMUST00000195566.2 Gm37490 (from geneSymbol) AK045815 ENSMUST00000195566.1 uc287ofl.1 uc287ofl.2 uc287ofl.1 uc287ofl.2 
ENSMUST00000195569.2 Gm38388 ENSMUST00000195569.2 Gm38388 (from geneSymbol) ENSMUST00000195569.1 uc287ipd.1 uc287ipd.2 uc287ipd.1 uc287ipd.2 
ENSMUST00000195572.2 Gm37440 ENSMUST00000195572.2 Gm37440 (from geneSymbol) ENSMUST00000195572.1 uc292sjd.1 uc292sjd.2 uc292sjd.1 uc292sjd.2 
ENSMUST00000195573.2 Gm38301 ENSMUST00000195573.2 Gm38301 (from geneSymbol) BC128294 ENSMUST00000195573.1 uc287ljn.1 uc287ljn.2 uc287ljn.1 uc287ljn.2 
ENSMUST00000195578.2 Gm37868 ENSMUST00000195578.2 Gm37868 (from geneSymbol) ENSMUST00000195578.1 LF192845 uc287lkw.1 uc287lkw.2 uc287lkw.1 uc287lkw.2 
ENSMUST00000195583.2 Gm33366 ENSMUST00000195583.2 Gm33366 (from geneSymbol) ENSMUST00000195583.1 uc288oxo.1 uc288oxo.2 uc288oxo.1 uc288oxo.2 
ENSMUST00000195585.2 Gm37891 ENSMUST00000195585.2 Gm37891 (from geneSymbol) AK047744 ENSMUST00000195585.1 uc289tgi.1 uc289tgi.2 uc289tgi.1 uc289tgi.2 
ENSMUST00000195587.2 1700018A14Rik ENSMUST00000195587.2 1700018A14Rik (from geneSymbol) AK006077 ENSMUST00000195587.1 uc289pac.1 uc289pac.2 uc289pac.1 uc289pac.2 
ENSMUST00000195593.2 Gm37198 ENSMUST00000195593.2 Gm37198 (from geneSymbol) AK037422 ENSMUST00000195593.1 uc287ipi.1 uc287ipi.2 uc287ipi.1 uc287ipi.2 
ENSMUST00000195599.2 Gm37169 ENSMUST00000195599.2 Gm37169 (from geneSymbol) DQ696484 ENSMUST00000195599.1 uc289vcx.1 uc289vcx.2 uc289vcx.1 uc289vcx.2 
ENSMUST00000195600.2 Gm38092 ENSMUST00000195600.2 Gm38092 (from geneSymbol) ENSMUST00000195600.1 uc292dxy.1 uc292dxy.2 uc292dxy.1 uc292dxy.2 
ENSMUST00000195606.2 Gm36467 ENSMUST00000195606.2 Gm36467 (from geneSymbol) ENSMUST00000195606.1 uc292smh.1 uc292smh.2 uc292smh.1 uc292smh.2 
ENSMUST00000195609.2 Gm38187 ENSMUST00000195609.2 Gm38187 (from geneSymbol) ENSMUST00000195609.1 uc287mjn.1 uc287mjn.2 uc287mjn.1 uc287mjn.2 
ENSMUST00000195610.2 Gm37890 ENSMUST00000195610.2 Gm37890 (from geneSymbol) ENSMUST00000195610.1 uc290ktv.1 uc290ktv.2 uc290ktv.1 uc290ktv.2 
ENSMUST00000195612.2 Zbtb18 ENSMUST00000195612.2 zinc finger and BTB domain containing 18, transcript variant 7 (from RefSeq NM_001355102.2) ENSMUST00000195612.1 NM_001355102 Q3UHU9 Q7TMA6 Q80YQ4 Q9WUK6 Rp58 ZBT18_MOUSE Zfp238 Znf238 uc287ogi.1 uc287ogi.2 Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus. Interacts with DNMT3A. Nucleus. Note=Associates with condensed chromatin. In the developing brain, expression is detected at embryonic day (E) 10 in the neuroepithelium, and subsequently in the ventricular zones of the cerebral cortex in the 12 dpc embryo. Strong expression is observed in the preplate in the cerebral cortex from this stage onward. High levels of expression continue to be detected in the cortical plate and subventricular zone of the neocortex, hippocampus, and parts of the amygdala, but not in the thalamus or striatum. In the developing cerebral cortex, it is expressed both in postmitotic glutamatergic projection neurons and in their progenitor cells, but not in GABAergic interneurons. Also expressed in the adult neocortex, hippocampus, parts of the amygdala and granule cells in the cerebellum. Death shortly after birth. Brain of mutant mice display dysplasia of the neocortex and of the hippocampus, reduction of the number of mature cortical neurons and defects of laminar organization. In the cortex, an impaired cell-division patterning during the late embryonic stage and an enhancement of apoptosis of the postmitotic neurons are observed. Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily. Sequence=AAH50909.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter in utero embryonic development nucleic acid binding DNA binding transcription coactivator activity nucleus cellular response to DNA damage stimulus multicellular organism development skeletal muscle tissue development cerebellum development hippocampus development cerebral cortex development sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding neuron development homeostasis of number of cells regulation of cell division uc287ogi.1 uc287ogi.2 
ENSMUST00000195618.2 Gm37529 ENSMUST00000195618.2 Gm37529 (from geneSymbol) AK042168 ENSMUST00000195618.1 uc287nae.1 uc287nae.2 uc287nae.1 uc287nae.2 
ENSMUST00000195619.2 Ighv3-5 ENSMUST00000195619.2 Ighv3-5 (from geneSymbol) A0A0A6YWB6 A0A0A6YWB6_MOUSE ENSMUST00000195619.1 Ighv3-5 uc288jwe.1 uc288jwe.2 uc288jwe.1 uc288jwe.2 
ENSMUST00000195625.2 Gm37447 ENSMUST00000195625.2 Gm37447 (from geneSymbol) ENSMUST00000195625.1 uc287kbr.1 uc287kbr.2 uc287kbr.1 uc287kbr.2 
ENSMUST00000195626.2 Gm21425 ENSMUST00000195626.2 Belongs to the SPIN/STSY family. (from UniProt Q3TTD8) ENSMUST00000195626.1 Gm20737 Gm20772 Gm20777 Gm20793 Gm20831 Gm21425 Gm21440 Q3TTD8 Q3TTD8_MOUSE uc292sgy.1 uc292sgy.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation methylated histone binding uc292sgy.1 uc292sgy.2 
ENSMUST00000195629.2 Gm37186 ENSMUST00000195629.2 Gm37186 (from geneSymbol) ENSMUST00000195629.1 uc289cca.1 uc289cca.2 uc289cca.1 uc289cca.2 
ENSMUST00000195630.2 Gm38307 ENSMUST00000195630.2 Gm38307 (from geneSymbol) ENSMUST00000195630.1 uc288ofe.1 uc288ofe.2 uc288ofe.1 uc288ofe.2 
ENSMUST00000195634.2 Gm37967 ENSMUST00000195634.2 Gm37967 (from geneSymbol) ENSMUST00000195634.1 uc287kbo.1 uc287kbo.2 uc287kbo.1 uc287kbo.2 
ENSMUST00000195637.2 Gm37291 ENSMUST00000195637.2 Gm37291 (from geneSymbol) ENSMUST00000195637.1 uc288gnm.1 uc288gnm.2 uc288gnm.1 uc288gnm.2 
ENSMUST00000195639.3 Gm42568 ENSMUST00000195639.3 Gm42568 (from geneSymbol) AK085855 ENSMUST00000195639.1 ENSMUST00000195639.2 uc290fun.1 uc290fun.2 uc290fun.1 uc290fun.2 
ENSMUST00000195641.2 Ighv16-1 ENSMUST00000195641.2 Ighv16-1 (from geneSymbol) A0A0A6YW39 A0A0A6YW39_MOUSE ENSMUST00000195641.1 Ighv16-1 uc288jvl.1 uc288jvl.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jvl.1 uc288jvl.2 
ENSMUST00000195644.2 Gm37907 ENSMUST00000195644.2 Gm37907 (from geneSymbol) ENSMUST00000195644.1 uc288qbd.1 uc288qbd.2 uc288qbd.1 uc288qbd.2 
ENSMUST00000195645.2 Gm37614 ENSMUST00000195645.2 Gm37614 (from geneSymbol) DQ691080 ENSMUST00000195645.1 uc292jmf.1 uc292jmf.2 uc292jmf.1 uc292jmf.2 
ENSMUST00000195657.6 Slc25a44 ENSMUST00000195657.6 solute carrier family 25, member 44, transcript variant 2 (from RefSeq NM_001145876.2) ENSMUST00000195657.1 ENSMUST00000195657.2 ENSMUST00000195657.3 ENSMUST00000195657.4 ENSMUST00000195657.5 NM_001145876 Q7TSU9 Q8BGF9 S2544_MOUSE Slc25a44 uc008pvd.1 uc008pvd.2 uc008pvd.3 uc008pvd.4 uc008pvd.5 Mitochondrial solute transporter which transports branched- chain amino acid (BCAA; valine, leucine and isoleucine) into mitochondria in brown adipose tissue (BAT) (PubMed:31435015). BAT is involved in BCAA catabolism and actively utilizes BCAA in the mitochondria for thermogenesis (PubMed:31435015). Reaction=L-valine(in) = L-valine(out); Xref=Rhea:RHEA:29703, ChEBI:CHEBI:57762; Evidence=; Reaction=L-leucine(in) = L-leucine(out); Xref=Rhea:RHEA:73011, ChEBI:CHEBI:57427; Evidence=; Mitochondrion membrane ; Multi-pass membrane protein Highly expressed in brown adipose tissues compared with other metabolic organs. Expression increases during adipogenesis. Induction by cold exposure in brown adipose tissues. Belongs to the mitochondrial carrier (TC 2.A.29) family. mitochondrion mitochondrial inner membrane membrane integral component of membrane transmembrane transporter activity transmembrane transport uc008pvd.1 uc008pvd.2 uc008pvd.3 uc008pvd.4 uc008pvd.5 
ENSMUST00000195660.6 Gm30705 ENSMUST00000195660.6 Gm30705 (from geneSymbol) ENSMUST00000195660.1 ENSMUST00000195660.2 ENSMUST00000195660.3 ENSMUST00000195660.4 ENSMUST00000195660.5 uc292sqy.1 uc292sqy.2 uc292sqy.1 uc292sqy.2 
ENSMUST00000195665.2 Gm37815 ENSMUST00000195665.2 Gm37815 (from geneSymbol) ENSMUST00000195665.1 uc288xdy.1 uc288xdy.2 uc288xdy.1 uc288xdy.2 
ENSMUST00000195666.2 A430110C17Rik ENSMUST00000195666.2 A430110C17Rik (from geneSymbol) ENSMUST00000195666.1 uc291ass.1 uc291ass.2 uc291ass.1 uc291ass.2 
ENSMUST00000195670.2 Gm37505 ENSMUST00000195670.2 Gm37505 (from geneSymbol) ENSMUST00000195670.1 uc287vfj.1 uc287vfj.2 uc287vfj.1 uc287vfj.2 
ENSMUST00000195672.2 5330406M23Rik ENSMUST00000195672.2 5330406M23Rik (from geneSymbol) ENSMUST00000195672.1 LF195383 uc291dgy.1 uc291dgy.2 uc291dgy.1 uc291dgy.2 
ENSMUST00000195675.2 Gm37113 ENSMUST00000195675.2 Gm37113 (from geneSymbol) AK137707 ENSMUST00000195675.1 uc292jww.1 uc292jww.2 uc292jww.1 uc292jww.2 
ENSMUST00000195676.2 Gm26616 ENSMUST00000195676.2 Gm26616 (from geneSymbol) AK084736 ENSMUST00000195676.1 uc287ltg.1 uc287ltg.2 uc287ltg.1 uc287ltg.2 
ENSMUST00000195677.2 Gm37613 ENSMUST00000195677.2 Gm37613 (from geneSymbol) AK143080 ENSMUST00000195677.1 uc291qgf.1 uc291qgf.2 uc291qgf.1 uc291qgf.2 
ENSMUST00000195679.2 Gm37253 ENSMUST00000195679.2 Gm37253 (from geneSymbol) ENSMUST00000195679.1 uc290oga.1 uc290oga.2 uc290oga.1 uc290oga.2 
ENSMUST00000195680.2 Gm37697 ENSMUST00000195680.2 Gm37697 (from geneSymbol) AB351616 ENSMUST00000195680.1 uc289tff.1 uc289tff.2 uc289tff.1 uc289tff.2 
ENSMUST00000195683.2 Gm30948 ENSMUST00000195683.2 predicted gene, 30948 (from RefSeq NR_166891.1) ENSMUST00000195683.1 NR_166891 uc288kap.1 uc288kap.2 uc288kap.1 uc288kap.2 
ENSMUST00000195685.2 A330015K06Rik ENSMUST00000195685.2 RIKEN cDNA A330015K06 gene (from RefSeq NR_126080.1) ENSMUST00000195685.1 NR_126080 uc008pkk.1 uc008pkk.2 uc008pkk.3 uc008pkk.4 uc008pkk.1 uc008pkk.2 uc008pkk.3 uc008pkk.4 
ENSMUST00000195687.2 Gm38021 ENSMUST00000195687.2 Gm38021 (from geneSymbol) AK142934 ENSMUST00000195687.1 uc287kbm.1 uc287kbm.2 uc287kbm.1 uc287kbm.2 
ENSMUST00000195692.2 Gm37466 ENSMUST00000195692.2 Gm37466 (from geneSymbol) AK144351 ENSMUST00000195692.1 uc289for.1 uc289for.2 uc289for.1 uc289for.2 
ENSMUST00000195694.2 Gm37090 ENSMUST00000195694.2 Gm37090 (from geneSymbol) AK132218 ENSMUST00000195694.1 uc290spq.1 uc290spq.2 uc290spq.1 uc290spq.2 
ENSMUST00000195696.2 Gm37608 ENSMUST00000195696.2 Gm37608 (from geneSymbol) ENSMUST00000195696.1 uc291rrg.1 uc291rrg.2 uc291rrg.1 uc291rrg.2 
ENSMUST00000195698.2 Gm38049 ENSMUST00000195698.2 Gm38049 (from geneSymbol) AK033755 ENSMUST00000195698.1 uc287hfy.1 uc287hfy.2 uc287hfy.1 uc287hfy.2 
ENSMUST00000195699.2 Gm37998 ENSMUST00000195699.2 Gm37998 (from geneSymbol) ENSMUST00000195699.1 uc292slr.1 uc292slr.2 uc292slr.1 uc292slr.2 
ENSMUST00000195700.2 Gm37634 ENSMUST00000195700.2 Gm37634 (from geneSymbol) ENSMUST00000195700.1 uc287nco.1 uc287nco.2 uc287nco.1 uc287nco.2 
ENSMUST00000195704.2 Gm38167 ENSMUST00000195704.2 Gm38167 (from geneSymbol) AK039389 ENSMUST00000195704.1 uc291hpt.1 uc291hpt.2 uc291hpt.1 uc291hpt.2 
ENSMUST00000195706.2 Ighv14-4 ENSMUST00000195706.2 Ighv14-4 (from geneSymbol) A0A0A6YVR1 A0A0A6YVR1_MOUSE ENSMUST00000195706.1 Ighv14-4 X14624 uc288jvv.1 uc288jvv.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jvv.1 uc288jvv.2 
ENSMUST00000195707.3 Ighv2-5 ENSMUST00000195707.3 Ighv2-5 (from geneSymbol) A0A0A6YY69 A0A0A6YY69_MOUSE AK144480 ENSMUST00000195707.1 ENSMUST00000195707.2 Ighv2-5 uc288jtv.1 uc288jtv.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jtv.1 uc288jtv.2 
ENSMUST00000195709.2 Gm38314 ENSMUST00000195709.2 Gm38314 (from geneSymbol) BC139733 ENSMUST00000195709.1 uc292kmb.1 uc292kmb.2 uc292kmb.1 uc292kmb.2 
ENSMUST00000195710.2 Gm38342 ENSMUST00000195710.2 Gm38342 (from geneSymbol) ENSMUST00000195710.1 uc287grc.1 uc287grc.2 uc287grc.1 uc287grc.2 
ENSMUST00000195711.2 Gm37555 ENSMUST00000195711.2 Gm37555 (from geneSymbol) ENSMUST00000195711.1 uc289nat.1 uc289nat.2 uc289nat.1 uc289nat.2 
ENSMUST00000195712.3 Gm37008 ENSMUST00000195712.3 Gm37008 (from geneSymbol) AK131858 ENSMUST00000195712.1 ENSMUST00000195712.2 uc291srf.1 uc291srf.2 uc291srf.3 uc291srf.1 uc291srf.2 uc291srf.3 
ENSMUST00000195714.2 Gm37305 ENSMUST00000195714.2 Gm37305 (from geneSymbol) AK044348 ENSMUST00000195714.1 uc056zsr.1 uc056zsr.2 uc056zsr.3 uc056zsr.4 uc056zsr.1 uc056zsr.2 uc056zsr.3 uc056zsr.4 
ENSMUST00000195718.2 Gm38380 ENSMUST00000195718.2 Gm38380 (from geneSymbol) ENSMUST00000195718.1 uc287gom.1 uc287gom.2 uc287gom.1 uc287gom.2 
ENSMUST00000195719.2 Gm38331 ENSMUST00000195719.2 Gm38331 (from geneSymbol) AK143701 ENSMUST00000195719.1 uc287ojg.1 uc287ojg.2 uc287ojg.1 uc287ojg.2 
ENSMUST00000195720.2 Gm38365 ENSMUST00000195720.2 Gm38365 (from geneSymbol) DQ543612 ENSMUST00000195720.1 uc287kek.1 uc287kek.2 uc287kek.1 uc287kek.2 
ENSMUST00000195723.2 Gm37077 ENSMUST00000195723.2 Gm37077 (from geneSymbol) ENSMUST00000195723.1 uc287gyi.1 uc287gyi.2 uc287gyi.1 uc287gyi.2 
ENSMUST00000195726.2 Gm37404 ENSMUST00000195726.2 Gm37404 (from geneSymbol) ENSMUST00000195726.1 uc290fow.1 uc290fow.2 uc290fow.1 uc290fow.2 
ENSMUST00000195730.2 Gm37067 ENSMUST00000195730.2 Gm37067 (from geneSymbol) ENSMUST00000195730.1 uc287hcs.1 uc287hcs.2 uc287hcs.1 uc287hcs.2 
ENSMUST00000195732.2 Gm38349 ENSMUST00000195732.2 Gm38349 (from geneSymbol) ENSMUST00000195732.1 uc288oub.1 uc288oub.2 uc288oub.1 uc288oub.2 
ENSMUST00000195733.2 Gm38090 ENSMUST00000195733.2 Gm38090 (from geneSymbol) ENSMUST00000195733.1 uc287hxd.1 uc287hxd.2 uc287hxd.1 uc287hxd.2 
ENSMUST00000195735.2 Ighv1-31 ENSMUST00000195735.2 Ighv1-31 (from geneSymbol) A0A0A6YWK5 A0A0A6YWK5_MOUSE BC029188 ENSMUST00000195735.1 Ighv1-31 uc288jyx.1 uc288jyx.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jyx.1 uc288jyx.2 
ENSMUST00000195736.2 Gm34073 ENSMUST00000195736.2 Gm34073 (from geneSymbol) ENSMUST00000195736.1 uc289pds.1 uc289pds.2 uc289pds.1 uc289pds.2 
ENSMUST00000195742.2 Gm37321 ENSMUST00000195742.2 Gm37321 (from geneSymbol) AK089454 ENSMUST00000195742.1 uc291czk.1 uc291czk.2 uc291czk.1 uc291czk.2 
ENSMUST00000195748.2 Gm37853 ENSMUST00000195748.2 Gm37853 (from geneSymbol) ENSMUST00000195748.1 uc287niz.1 uc287niz.2 uc287niz.1 uc287niz.2 
ENSMUST00000195749.6 Nsun6 ENSMUST00000195749.6 S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA). In vitro also methylates tRNA(Thr)(AGT). Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates. (from UniProt Q7TS68) BC053751 ENSMUST00000195749.1 ENSMUST00000195749.2 ENSMUST00000195749.3 ENSMUST00000195749.4 ENSMUST00000195749.5 NSUN6_MOUSE Nsun6 Q7TS68 Q8R3C4 Q9D445 uc289tgk.1 uc289tgk.2 S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA). In vitro also methylates tRNA(Thr)(AGT). Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates. Reaction=cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine = 5- methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:21124, Rhea:RHEA-COMP:15877, Rhea:RHEA-COMP:15878, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21125; Evidence=; Reaction=cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine = 5- methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61584, Rhea:RHEA-COMP:15875, Rhea:RHEA-COMP:15876, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61585; Evidence=; Cytoplasm The PUA domain plays a role in tRNA recognition through precisely recognizing the CCA end and the D-stem region of tRNA. Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. Sequence=AAH25622.1; Type=Erroneous initiation; Evidence=; tRNA binding RNA binding cytoplasm methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity transferase activity tRNA methylation methylation uc289tgk.1 uc289tgk.2 
ENSMUST00000195752.6 Hyal2 ENSMUST00000195752.6 hyaluronoglucosaminidase 2, transcript variant 2 (from RefSeq NM_001409671.1) ENSMUST00000195752.1 ENSMUST00000195752.2 ENSMUST00000195752.3 ENSMUST00000195752.4 ENSMUST00000195752.5 Hyal2 NM_001409671 Q3UZE4 Q3UZE4_MOUSE uc009rlu.1 uc009rlu.2 uc009rlu.3 Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D- glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35; Evidence= Cell membrane ; Lipid-anchor, GPI-anchor Membrane ; Lipid-anchor, GPI-anchor Belongs to the glycosyl hydrolase 56 family. response to reactive oxygen species virus receptor activity catalytic activity hyalurononglucosaminidase activity hyaluronic acid binding cytoplasm lysosome cytosol microvillus carbohydrate metabolic process glycosaminoglycan catabolic process metabolic process response to virus cell surface negative regulation of fibroblast migration apical plasma membrane hydrolase activity hydrolase activity, acting on glycosyl bonds fusion of virus membrane with host plasma membrane transformation of host cell by virus enzyme binding endocytic vesicle hyaluronan catabolic process receptor signaling protein tyrosine kinase inhibitor activity negative regulation of cell growth receptor tyrosine kinase binding anchored component of external side of plasma membrane cytoplasmic vesicle hyaluronoglucuronidase activity monocyte activation negative regulation of MAP kinase activity cellular response to fibroblast growth factor stimulus membrane raft anchored component of plasma membrane response to antibiotic perinuclear region of cytoplasm positive regulation of inflammatory response cartilage development negative regulation of protein kinase B signaling negative regulation of protein tyrosine kinase activity cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to UV-B cellular response to transforming growth factor beta stimulus positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion uc009rlu.1 uc009rlu.2 uc009rlu.3 
ENSMUST00000195753.2 Gm37312 ENSMUST00000195753.2 Gm37312 (from geneSymbol) ENSMUST00000195753.1 uc287xov.1 uc287xov.2 uc287xov.1 uc287xov.2 
ENSMUST00000195754.2 2900002M20Rik ENSMUST00000195754.2 2900002M20Rik (from geneSymbol) AK019302 ENSMUST00000195754.1 uc287gyn.1 uc287gyn.2 uc287gyn.1 uc287gyn.2 
ENSMUST00000195759.6 Gm32114 ENSMUST00000195759.6 Gm32114 (from geneSymbol) ENSMUST00000195759.1 ENSMUST00000195759.2 ENSMUST00000195759.3 ENSMUST00000195759.4 ENSMUST00000195759.5 uc292snq.1 uc292snq.2 uc292snq.1 uc292snq.2 
ENSMUST00000195761.2 Gm37792 ENSMUST00000195761.2 Gm37792 (from geneSymbol) ENSMUST00000195761.1 uc287hbd.1 uc287hbd.2 uc287hbd.1 uc287hbd.2 
ENSMUST00000195764.2 Pcdhgb8 ENSMUST00000195764.2 protocadherin gamma subfamily B, 8, transcript variant 1, non-coding (from RefSeq NR_160734.1) ENSMUST00000195764.1 NR_160734 uc289ous.1 uc289ous.2 uc289ous.1 uc289ous.2 
ENSMUST00000195767.2 Gm37973 ENSMUST00000195767.2 Gm37973 (from geneSymbol) AK034921 ENSMUST00000195767.1 uc290gbq.1 uc290gbq.2 uc290gbq.1 uc290gbq.2 
ENSMUST00000195769.2 Gm38318 ENSMUST00000195769.2 Gm38318 (from geneSymbol) ENSMUST00000195769.1 uc292dcf.1 uc292dcf.2 uc292dcf.1 uc292dcf.2 
ENSMUST00000195772.2 Gm10463 ENSMUST00000195772.2 Gm10463 (from geneSymbol) AK136299 ENSMUST00000195772.1 uc290ujj.1 uc290ujj.2 uc290ujj.1 uc290ujj.2 
ENSMUST00000195774.2 Gm38220 ENSMUST00000195774.2 Gm38220 (from geneSymbol) ENSMUST00000195774.1 uc289mqr.1 uc289mqr.2 uc289mqr.1 uc289mqr.2 
ENSMUST00000195777.2 Gm37969 ENSMUST00000195777.2 Gm37969 (from geneSymbol) AK140105 ENSMUST00000195777.1 uc291fvw.1 uc291fvw.2 uc291fvw.1 uc291fvw.2 
ENSMUST00000195780.3 Gm42492 ENSMUST00000195780.3 Gm42492 (from geneSymbol) ENSMUST00000195780.1 ENSMUST00000195780.2 uc287ghc.1 uc287ghc.2 uc287ghc.1 uc287ghc.2 
ENSMUST00000195781.3 C230057A21Rik ENSMUST00000195781.3 C230057A21Rik (from geneSymbol) ENSMUST00000195781.1 ENSMUST00000195781.2 uc290duf.1 uc290duf.2 uc290duf.3 uc290duf.1 uc290duf.2 uc290duf.3 
ENSMUST00000195783.2 Gm37785 ENSMUST00000195783.2 Gm37785 (from geneSymbol) AK043627 ENSMUST00000195783.1 uc287oth.1 uc287oth.2 uc287oth.1 uc287oth.2 
ENSMUST00000195785.2 Gm38085 ENSMUST00000195785.2 Gm38085 (from geneSymbol) DQ560184 ENSMUST00000195785.1 uc289sri.1 uc289sri.2 uc289sri.1 uc289sri.2 
ENSMUST00000195786.2 Gm38343 ENSMUST00000195786.2 Gm38343 (from geneSymbol) ENSMUST00000195786.1 uc290mpo.1 uc290mpo.2 uc290mpo.1 uc290mpo.2 
ENSMUST00000195792.2 Gm38071 ENSMUST00000195792.2 Gm38071 (from geneSymbol) ENSMUST00000195792.1 uc289fov.1 uc289fov.2 uc289fov.1 uc289fov.2 
ENSMUST00000195795.6 Gm37378 ENSMUST00000195795.6 Gm37378 (from geneSymbol) ENSMUST00000195795.1 ENSMUST00000195795.2 ENSMUST00000195795.3 ENSMUST00000195795.4 ENSMUST00000195795.5 uc292shm.1 uc292shm.2 uc292shm.1 uc292shm.2 
ENSMUST00000195797.2 Tcstv6 ENSMUST00000195797.2 Tcstv family member 6 (from RefSeq NM_001424715.1) D13Ertd608e ENSMUST00000195797.1 Gm21762 NM_001424715 Q3UPR8 Q3UPR8_MOUSE uc029sdo.1 uc029sdo.2 uc029sdo.3 uc029sdo.1 uc029sdo.2 uc029sdo.3 
ENSMUST00000195799.2 4933431K14Rik ENSMUST00000195799.2 4933431K14Rik (from geneSymbol) AK017009 ENSMUST00000195799.1 uc292jhr.1 uc292jhr.2 uc292jhr.1 uc292jhr.2 
ENSMUST00000195805.2 2900018N21Rik ENSMUST00000195805.2 2900018N21Rik (from geneSymbol) ENSMUST00000195805.1 uc287wuf.1 uc287wuf.2 uc287wuf.1 uc287wuf.2 
ENSMUST00000195806.2 Gm38139 ENSMUST00000195806.2 Gm38139 (from geneSymbol) ENSMUST00000195806.1 uc290ktq.1 uc290ktq.2 uc290ktq.1 uc290ktq.2 
ENSMUST00000195807.2 1700016D08Rik ENSMUST00000195807.2 1700016D08Rik (from geneSymbol) AK018837 ENSMUST00000195807.1 uc289cal.1 uc289cal.2 uc289cal.1 uc289cal.2 
ENSMUST00000195810.2 Gm37134 ENSMUST00000195810.2 Gm37134 (from geneSymbol) ENSMUST00000195810.1 uc287oua.1 uc287oua.2 uc287oua.1 uc287oua.2 
ENSMUST00000195811.2 Gm37409 ENSMUST00000195811.2 Gm37409 (from geneSymbol) AK032781 ENSMUST00000195811.1 uc287goh.1 uc287goh.2 uc287goh.1 uc287goh.2 
ENSMUST00000195813.2 Gm38268 ENSMUST00000195813.2 Gm38268 (from geneSymbol) ENSMUST00000195813.1 LF193081 uc287oty.1 uc287oty.2 uc287oty.1 uc287oty.2 
ENSMUST00000195814.6 Gm37071 ENSMUST00000195814.6 Gm37071 (from geneSymbol) ENSMUST00000195814.1 ENSMUST00000195814.2 ENSMUST00000195814.3 ENSMUST00000195814.4 ENSMUST00000195814.5 uc292sqr.1 uc292sqr.2 uc292sqr.1 uc292sqr.2 
ENSMUST00000195815.3 Traf5 ENSMUST00000195815.3 TNF receptor-associated factor 5 (from RefSeq NM_011633.2) ENSMUST00000195815.1 ENSMUST00000195815.2 NM_011633 Q3UMS9 Q3UMS9_MOUSE Traf5 uc287paq.1 uc287paq.2 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Cytoplasm Belongs to the TNF receptor-associated factor family. A subfamily. tumor necrosis factor receptor binding cytoplasm signal transduction zinc ion binding regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling metal ion binding uc287paq.1 uc287paq.2 
ENSMUST00000195819.3 Gm36888 ENSMUST00000195819.3 Gm36888 (from geneSymbol) AK085270 ENSMUST00000195819.1 ENSMUST00000195819.2 uc290klq.1 uc290klq.2 uc290klq.3 uc290klq.1 uc290klq.2 uc290klq.3 
ENSMUST00000195820.2 Gm37814 ENSMUST00000195820.2 Gm37814 (from geneSymbol) AK140085 ENSMUST00000195820.1 uc289srm.1 uc289srm.2 uc289srm.1 uc289srm.2 
ENSMUST00000195823.2 Pcdhga6 ENSMUST00000195823.2 protocadherin gamma subfamily A, 6 (from RefSeq NM_033589.2) ENSMUST00000195823.1 NM_033589 Pcdhga6 Q91XY2 Q91XY2_MOUSE uc008eqs.1 uc008eqs.2 uc008eqs.3 uc008eqs.4 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein molecular_function calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane uc008eqs.1 uc008eqs.2 uc008eqs.3 uc008eqs.4 
ENSMUST00000195828.2 Gm37908 ENSMUST00000195828.2 Gm37908 (from geneSymbol) ENSMUST00000195828.1 uc287tqu.1 uc287tqu.2 uc287tqu.1 uc287tqu.2 
ENSMUST00000195830.2 Gm37497 ENSMUST00000195830.2 Gm37497 (from geneSymbol) ENSMUST00000195830.1 uc292drj.1 uc292drj.2 uc292drj.1 uc292drj.2 
ENSMUST00000195831.2 Gm36307 ENSMUST00000195831.2 predicted gene, 36307 (from RefSeq NR_188982.1) ENSMUST00000195831.1 NR_188982 uc007dtm.1 uc007dtm.2 uc007dtm.3 uc007dtm.1 uc007dtm.2 uc007dtm.3 
ENSMUST00000195835.2 Gm37021 ENSMUST00000195835.2 Gm37021 (from geneSymbol) ENSMUST00000195835.1 uc290edb.1 uc290edb.2 uc290edb.1 uc290edb.2 
ENSMUST00000195836.2 Gm19335 ENSMUST00000195836.2 Gm19335 (from geneSymbol) AK051247 ENSMUST00000195836.1 uc287iyp.1 uc287iyp.2 uc287iyp.1 uc287iyp.2 
ENSMUST00000195837.2 Gm37263 ENSMUST00000195837.2 Gm37263 (from geneSymbol) ENSMUST00000195837.1 uc292shw.1 uc292shw.2 uc292shw.1 uc292shw.2 
ENSMUST00000195842.2 A630081D01Rik ENSMUST00000195842.2 A630081D01Rik (from geneSymbol) AK042310 ENSMUST00000195842.1 uc287jrf.1 uc287jrf.2 uc287jrf.1 uc287jrf.2 
ENSMUST00000195845.2 A930032L01Rik ENSMUST00000195845.2 A930032L01Rik (from geneSymbol) AK020918 ENSMUST00000195845.1 uc288ntq.1 uc288ntq.2 uc288ntq.1 uc288ntq.2 
ENSMUST00000195847.2 Tdpoz8 ENSMUST00000195847.2 TD and POZ domain containing 8, transcript variant 1 (from RefSeq NM_001177694.1) A0A0A6YWS7 A0A0A6YWS7_MOUSE ENSMUST00000195847.1 Gm4858 NM_001177694 Tdpoz8 uc290hfd.1 uc290hfd.2 Belongs to the Tdpoz family. nucleus cytoplasm ubiquitin-dependent protein catabolic process regulation of proteolysis ubiquitin protein ligase binding proteasome-mediated ubiquitin-dependent protein catabolic process uc290hfd.1 uc290hfd.2 
ENSMUST00000195852.2 Gm38327 ENSMUST00000195852.2 Gm38327 (from geneSymbol) AK133151 ENSMUST00000195852.1 uc292jxx.1 uc292jxx.2 uc292jxx.1 uc292jxx.2 
ENSMUST00000195853.2 Gm37332 ENSMUST00000195853.2 Gm37332 (from geneSymbol) ENSMUST00000195853.1 uc289gyy.1 uc289gyy.2 uc289gyy.1 uc289gyy.2 
ENSMUST00000195858.2 Ighd5-6 ENSMUST00000195858.2 Ighd5-6 (from geneSymbol) ENSMUST00000195858.1 uc288jsg.1 uc288jsg.2 uc288jsg.1 uc288jsg.2 
ENSMUST00000195864.2 Gm38094 ENSMUST00000195864.2 Gm38094 (from geneSymbol) ENSMUST00000195864.1 uc292sls.1 uc292sls.2 uc292sls.1 uc292sls.2 
ENSMUST00000195870.3 Mgam2-ps ENSMUST00000195870.3 Belongs to the glycosyl hydrolase 31 family. (from UniProt A0A571BDS5) A0A571BDS5 A0A571BDS5_MOUSE ENSMUST00000195870.1 ENSMUST00000195870.2 Mgam2-ps uc291dtt.1 uc291dtt.2 uc291dtt.3 Belongs to the glycosyl hydrolase 31 family. Lacks conserved residue(s) required for the propagation of feature annotation. uc291dtt.1 uc291dtt.2 uc291dtt.3 
ENSMUST00000195874.6 Gm37130 ENSMUST00000195874.6 Gm37130 (from geneSymbol) ENSMUST00000195874.1 ENSMUST00000195874.2 ENSMUST00000195874.3 ENSMUST00000195874.4 ENSMUST00000195874.5 uc292shz.1 uc292shz.2 uc292shz.1 uc292shz.2 
ENSMUST00000195877.3 Gm37125 ENSMUST00000195877.3 Gm37125 (from geneSymbol) ENSMUST00000195877.1 ENSMUST00000195877.2 LF193027 uc287nyx.1 uc287nyx.2 uc287nyx.3 uc287nyx.1 uc287nyx.2 uc287nyx.3 
ENSMUST00000195879.2 Gm38263 ENSMUST00000195879.2 Gm38263 (from geneSymbol) ENSMUST00000195879.1 uc287lhp.1 uc287lhp.2 uc287lhp.1 uc287lhp.2 
ENSMUST00000195880.2 Gm37755 ENSMUST00000195880.2 Gm37755 (from geneSymbol) ENSMUST00000195880.1 LF192696 uc287ixl.1 uc287ixl.2 uc287ixl.1 uc287ixl.2 
ENSMUST00000195881.2 Gm38257 ENSMUST00000195881.2 Gm38257 (from geneSymbol) AK143145 ENSMUST00000195881.1 uc289tgr.1 uc289tgr.2 uc289tgr.1 uc289tgr.2 
ENSMUST00000195884.2 Ighv9-1 ENSMUST00000195884.2 Ighv9-1 (from geneSymbol) A0A0B4J1P3 A0A0B4J1P3_MOUSE E06646 ENSMUST00000195884.1 Ighv9-1 uc288jvo.1 uc288jvo.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jvo.1 uc288jvo.2 
ENSMUST00000195885.2 Gm37286 ENSMUST00000195885.2 Gm37286 (from geneSymbol) ENSMUST00000195885.1 uc292skl.1 uc292skl.2 uc292skl.1 uc292skl.2 
ENSMUST00000195887.2 Gm42922 ENSMUST00000195887.2 Gm42922 (from geneSymbol) AK134839 ENSMUST00000195887.1 uc290etm.1 uc290etm.2 uc290etm.1 uc290etm.2 
ENSMUST00000195888.3 Mir6920 ENSMUST00000195888.3 microRNA 6920 (from RefSeq NR_105885.1) ENSMUST00000195888.1 ENSMUST00000195888.2 NR_105885 uc033fvm.1 uc033fvm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fvm.1 uc033fvm.2 
ENSMUST00000195890.2 Gm43127 ENSMUST00000195890.2 Gm43127 (from geneSymbol) ENSMUST00000195890.1 uc292lsw.1 uc292lsw.2 uc292lsw.1 uc292lsw.2 
ENSMUST00000195892.2 Gm9484 ENSMUST00000195892.2 predicted gene 9484 (from RefSeq NR_188767.1) ENSMUST00000195892.1 NR_188767 uc290xig.1 uc290xig.2 uc290xig.1 uc290xig.2 
ENSMUST00000195895.2 4933415J04Rik ENSMUST00000195895.2 4933415J04Rik (from geneSymbol) AK016822 ENSMUST00000195895.1 uc290ykc.1 uc290ykc.2 uc290ykc.1 uc290ykc.2 
ENSMUST00000195908.2 Gm42630 ENSMUST00000195908.2 Gm42630 (from geneSymbol) ENSMUST00000195908.1 uc290jps.1 uc290jps.2 uc290jps.1 uc290jps.2 
ENSMUST00000195914.2 Gm43174 ENSMUST00000195914.2 Gm43174 (from geneSymbol) AK032968 ENSMUST00000195914.1 uc290vlx.1 uc290vlx.2 uc290vlx.1 uc290vlx.2 
ENSMUST00000195915.2 Gm42759 ENSMUST00000195915.2 Gm42759 (from geneSymbol) ENSMUST00000195915.1 uc290xir.1 uc290xir.2 uc290xir.1 uc290xir.2 
ENSMUST00000195919.2 Gm42866 ENSMUST00000195919.2 Gm42866 (from geneSymbol) ENSMUST00000195919.1 uc290zgy.1 uc290zgy.2 uc290zgy.1 uc290zgy.2 
ENSMUST00000195921.2 Gm43409 ENSMUST00000195921.2 Gm43409 (from geneSymbol) ENSMUST00000195921.1 uc290zom.1 uc290zom.2 uc290zom.1 uc290zom.2 
ENSMUST00000195925.2 Gm43201 ENSMUST00000195925.2 Gm43201 (from geneSymbol) ENSMUST00000195925.1 uc290vhu.1 uc290vhu.2 uc290vhu.1 uc290vhu.2 
ENSMUST00000195930.3 Mir376b ENSMUST00000195930.3 microRNA 376b (from RefSeq NR_029915.1) ENSMUST00000195930.1 ENSMUST00000195930.2 NR_029915 uc011ytp.1 uc011ytp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608804.1 [ECO:0000345] ##Evidence-Data-END## uc011ytp.1 uc011ytp.2 
ENSMUST00000195931.2 Gm42439 ENSMUST00000195931.2 Gm42439 (from geneSymbol) ENSMUST00000195931.1 uc291aho.1 uc291aho.2 uc291aho.1 uc291aho.2 
ENSMUST00000195932.2 Gm43835 ENSMUST00000195932.2 Gm43835 (from geneSymbol) AK199184 ENSMUST00000195932.1 uc290vtp.1 uc290vtp.2 uc290vtp.1 uc290vtp.2 
ENSMUST00000195936.2 4930408K08Rik ENSMUST00000195936.2 4930408K08Rik (from geneSymbol) AK015112 ENSMUST00000195936.1 uc290ivb.1 uc290ivb.2 uc290ivb.1 uc290ivb.2 
ENSMUST00000195938.2 Gm43606 ENSMUST00000195938.2 Gm43606 (from geneSymbol) ENSMUST00000195938.1 uc290vlt.1 uc290vlt.2 uc290vlt.1 uc290vlt.2 
ENSMUST00000195945.2 Igkv8-16 ENSMUST00000195945.2 Igkv8-16 (from geneSymbol) A0A0G2JDG9 A0A0G2JDG9_MOUSE BC082779 ENSMUST00000195945.1 Igkv8-16 uc291foc.1 uc291foc.2 immunoglobulin production extracellular space immune response uc291foc.1 uc291foc.2 
ENSMUST00000195951.4 Gm43689 ENSMUST00000195951.4 Gm43689 (from geneSymbol) ENSMUST00000195951.1 ENSMUST00000195951.2 ENSMUST00000195951.3 uc290kan.1 uc290kan.2 uc290kan.3 uc290kan.4 uc290kan.1 uc290kan.2 uc290kan.3 uc290kan.4 
ENSMUST00000195956.3 Mir7116 ENSMUST00000195956.3 microRNA 7116 (from RefSeq NR_130343.1) ENSMUST00000195956.1 ENSMUST00000195956.2 NR_130343 uc056yol.1 uc056yol.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yol.1 uc056yol.2 
ENSMUST00000195958.2 Gm43705 ENSMUST00000195958.2 Gm43705 (from geneSymbol) AK036287 ENSMUST00000195958.1 uc290vpp.1 uc290vpp.2 uc290vpp.1 uc290vpp.2 
ENSMUST00000195964.2 Gm42994 ENSMUST00000195964.2 Gm42994 (from geneSymbol) ENSMUST00000195964.1 LF194191 uc290jhj.1 uc290jhj.2 uc290jhj.1 uc290jhj.2 
ENSMUST00000195967.2 Gm43463 ENSMUST00000195967.2 Gm43463 (from geneSymbol) AK148920 ENSMUST00000195967.1 uc290ibd.1 uc290ibd.2 uc290ibd.1 uc290ibd.2 
ENSMUST00000195977.3 Mir7230 ENSMUST00000195977.3 microRNA 7230 (from RefSeq NR_106089.1) ENSMUST00000195977.1 ENSMUST00000195977.2 NR_106089 uc008yvp.1 uc008yvp.2 uc008yvp.3 uc008yvp.4 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc008yvp.1 uc008yvp.2 uc008yvp.3 uc008yvp.4 
ENSMUST00000195987.2 Gm43590 ENSMUST00000195987.2 Gm43590 (from geneSymbol) DQ557916 ENSMUST00000195987.1 uc290jjh.1 uc290jjh.2 uc290jjh.1 uc290jjh.2 
ENSMUST00000195989.2 Mir101c ENSMUST00000195989.2 microRNA 101c (from RefSeq NR_039546.1) ENSMUST00000195989.1 NR_039546 uc029wxb.1 uc029wxb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611361.1 [ECO:0000345] ##Evidence-Data-END## uc029wxb.1 uc029wxb.2 
ENSMUST00000195990.3 Gm42984 ENSMUST00000195990.3 Gm42984 (from geneSymbol) AK149205 ENSMUST00000195990.1 ENSMUST00000195990.2 uc008xiq.1 uc008xiq.2 uc008xiq.3 uc008xiq.4 uc008xiq.1 uc008xiq.2 uc008xiq.3 uc008xiq.4 
ENSMUST00000195991.2 4933425M03Rik ENSMUST00000195991.2 4933425M03Rik (from geneSymbol) AK016922 ENSMUST00000195991.1 uc290ghb.1 uc290ghb.2 uc290ghb.1 uc290ghb.2 
ENSMUST00000195992.4 Gm38102 ENSMUST00000195992.4 Gm38102 (from geneSymbol) ENSMUST00000195992.1 ENSMUST00000195992.2 ENSMUST00000195992.3 LF195162 uc290zod.1 uc290zod.2 uc290zod.3 uc290zod.4 uc290zod.1 uc290zod.2 uc290zod.3 uc290zod.4 
ENSMUST00000195993.2 Gm43010 ENSMUST00000195993.2 Gm43010 (from geneSymbol) AK035308 ENSMUST00000195993.1 uc290jlf.1 uc290jlf.2 uc290jlf.1 uc290jlf.2 
ENSMUST00000195997.2 C820005J03Rik ENSMUST00000195997.2 C820005J03Rik (from geneSymbol) AK050480 ENSMUST00000195997.1 uc008pez.1 uc008pez.2 uc008pez.1 uc008pez.2 
ENSMUST00000196003.2 Gm42716 ENSMUST00000196003.2 Gm42716 (from geneSymbol) ENSMUST00000196003.1 uc290vev.1 uc290vev.2 uc290vev.1 uc290vev.2 
ENSMUST00000196005.3 4921527H02Rik ENSMUST00000196005.3 4921527H02Rik (from geneSymbol) ENSMUST00000196005.1 ENSMUST00000196005.2 uc290jjx.1 uc290jjx.2 uc290jjx.1 uc290jjx.2 
ENSMUST00000196006.5 Igkv14-130 ENSMUST00000196006.5 Igkv14-130 (from geneSymbol) A0A0G2JF45 A0A0G2JF45_MOUSE ENSMUST00000196006.1 ENSMUST00000196006.2 ENSMUST00000196006.3 ENSMUST00000196006.4 Igkv14-130 uc291fgg.1 uc291fgg.2 immunoglobulin production extracellular space immune response uc291fgg.1 uc291fgg.2 
ENSMUST00000196013.2 Gm42564 ENSMUST00000196013.2 Gm42564 (from geneSymbol) ENSMUST00000196013.1 uc290vts.1 uc290vts.2 uc290vts.1 uc290vts.2 
ENSMUST00000196016.2 Gm3364 ENSMUST00000196016.2 Gm3364 (from geneSymbol) AK090251 ENSMUST00000196016.1 uc290vgc.1 uc290vgc.2 uc290vgc.1 uc290vgc.2 
ENSMUST00000196018.2 A930036I15Rik ENSMUST00000196018.2 A930036I15Rik (from geneSymbol) AK020934 ENSMUST00000196018.1 uc290jmj.1 uc290jmj.2 uc290jmj.1 uc290jmj.2 
ENSMUST00000196019.2 Gm42833 ENSMUST00000196019.2 Gm42833 (from geneSymbol) AK132908 ENSMUST00000196019.1 uc290tco.1 uc290tco.2 uc290tco.1 uc290tco.2 
ENSMUST00000196023.2 Trav3d-3 ENSMUST00000196023.2 Trav3d-3 (from geneSymbol) A0A0G2JEM0 A0A0G2JEM0_MOUSE ENSMUST00000196023.1 Trav3d-3 Trav3n-3 uc288txu.1 uc288txu.2 uc288txu.1 uc288txu.2 
ENSMUST00000196025.5 Mllt11 ENSMUST00000196025.5 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11, transcript variant 4 (from RefSeq NM_001411092.1) ENSMUST00000196025.1 ENSMUST00000196025.2 ENSMUST00000196025.3 ENSMUST00000196025.4 Mllt11 NM_001411092 Q543U0 Q543U0_MOUSE uc033hxa.1 uc033hxa.2 uc033hxa.3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Belongs to the MLLT11 family. nucleoplasm cytosol positive regulation of apoptotic process positive regulation of transcription, DNA-templated positive regulation of mitochondrial depolarization positive regulation of release of cytochrome c from mitochondria apoptotic signaling pathway extrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway uc033hxa.1 uc033hxa.2 uc033hxa.3 
ENSMUST00000196026.2 Gm42777 ENSMUST00000196026.2 Gm42777 (from geneSymbol) ENSMUST00000196026.1 uc290jez.1 uc290jez.2 uc290jez.1 uc290jez.2 
ENSMUST00000196033.2 9330178D15Rik ENSMUST00000196033.2 RIKEN cDNA 9330178D15 gene (from RefSeq NR_040553.1) ENSMUST00000196033.1 NR_040553 uc029uph.1 uc029uph.2 uc029uph.1 uc029uph.2 
ENSMUST00000196040.2 Gm43189 ENSMUST00000196040.2 Gm43189 (from geneSymbol) ENSMUST00000196040.1 uc290hye.1 uc290hye.2 uc290hye.1 uc290hye.2 
ENSMUST00000196044.2 C230071H17Rik ENSMUST00000196044.2 C230071H17Rik (from geneSymbol) AK084279 ENSMUST00000196044.1 uc291ahl.1 uc291ahl.2 uc291ahl.1 uc291ahl.2 
ENSMUST00000196046.2 Gm43364 ENSMUST00000196046.2 Gm43364 (from geneSymbol) ENSMUST00000196046.1 uc290xyy.1 uc290xyy.2 uc290xyy.1 uc290xyy.2 
ENSMUST00000196047.2 Gm43320 ENSMUST00000196047.2 Gm43320 (from geneSymbol) ENSMUST00000196047.1 uc290vjy.1 uc290vjy.2 uc290vjy.1 uc290vjy.2 
ENSMUST00000196051.3 Mir7657 ENSMUST00000196051.3 microRNA 7657 (from RefSeq NR_106117.1) ENSMUST00000196051.1 ENSMUST00000196051.2 NR_106117 uc033hzk.1 uc033hzk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hzk.1 uc033hzk.2 
ENSMUST00000196056.2 Gm43504 ENSMUST00000196056.2 Gm43504 (from geneSymbol) ENSMUST00000196056.1 uc290vga.1 uc290vga.2 uc290vga.1 uc290vga.2 
ENSMUST00000196063.2 Gm42534 ENSMUST00000196063.2 Gm42534 (from geneSymbol) AK028006 ENSMUST00000196063.1 uc290vjd.1 uc290vjd.2 uc290vjd.1 uc290vjd.2 
ENSMUST00000196065.2 Gm42638 ENSMUST00000196065.2 Gm42638 (from geneSymbol) AK054523 ENSMUST00000196065.1 uc292lqb.1 uc292lqb.2 uc292lqb.1 uc292lqb.2 
ENSMUST00000196072.2 Gm43693 ENSMUST00000196072.2 Gm43693 (from geneSymbol) ENSMUST00000196072.1 uc290umb.1 uc290umb.2 uc290umb.1 uc290umb.2 
ENSMUST00000196073.3 Mir30f ENSMUST00000196073.3 microRNA 30f (from RefSeq NR_105851.1) ENSMUST00000196073.1 ENSMUST00000196073.2 NR_105851 uc033iee.1 uc033iee.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM608335.1 [ECO:0000345] ##Evidence-Data-END## uc033iee.1 uc033iee.2 
ENSMUST00000196075.2 Gm42484 ENSMUST00000196075.2 Gm42484 (from geneSymbol) AK053939 ENSMUST00000196075.1 uc290vqr.1 uc290vqr.2 uc290vqr.1 uc290vqr.2 
ENSMUST00000196079.2 Trav13d-4 ENSMUST00000196079.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A0G2JFX3) A0A0G2JFX3 A0A0G2JFX3_MOUSE ENSMUST00000196079.1 Trav13d-4 U23509 uc288tyf.1 uc288tyf.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc288tyf.1 uc288tyf.2 
ENSMUST00000196080.2 Gm43389 ENSMUST00000196080.2 Gm43389 (from geneSymbol) ENSMUST00000196080.1 uc290tpn.1 uc290tpn.2 uc290tpn.1 uc290tpn.2 
ENSMUST00000196081.5 P2ry14 ENSMUST00000196081.5 purinergic receptor P2Y, G-protein coupled, 14, transcript variant 3 (from RefSeq NM_001287119.1) ENSMUST00000196081.1 ENSMUST00000196081.2 ENSMUST00000196081.3 ENSMUST00000196081.4 Gpr105 NM_001287119 P2Y14_MOUSE Q9ESG6 uc008pin.1 uc008pin.2 uc008pin.3 uc008pin.4 Receptor for UDP-glucose coupled to G-proteins. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane immune response signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane G-protein coupled purinergic nucleotide receptor signaling pathway G-protein coupled purinergic nucleotide receptor activity uc008pin.1 uc008pin.2 uc008pin.3 uc008pin.4 
ENSMUST00000196083.2 Gm43143 ENSMUST00000196083.2 Gm43143 (from geneSymbol) ENSMUST00000196083.1 LF194875 uc290tun.1 uc290tun.2 uc290tun.1 uc290tun.2 
ENSMUST00000196084.2 Gm43469 ENSMUST00000196084.2 Gm43469 (from geneSymbol) ENSMUST00000196084.1 uc290knd.1 uc290knd.2 uc290knd.1 uc290knd.2 
ENSMUST00000196086.2 Gm42942 ENSMUST00000196086.2 Gm42942 (from geneSymbol) ENSMUST00000196086.1 uc290kuu.1 uc290kuu.2 uc290kuu.1 uc290kuu.2 
ENSMUST00000196087.2 Gm43612 ENSMUST00000196087.2 Gm43612 (from geneSymbol) DQ542432 ENSMUST00000196087.1 uc290kgc.1 uc290kgc.2 uc290kgc.1 uc290kgc.2 
ENSMUST00000196088.2 4930509H03Rik ENSMUST00000196088.2 4930509H03Rik (from geneSymbol) ENSMUST00000196088.1 uc290iiw.1 uc290iiw.2 uc290iiw.1 uc290iiw.2 
ENSMUST00000196089.3 Mir509 ENSMUST00000196089.3 microRNA 509 (from RefSeq NR_030575.1) ENSMUST00000196089.1 ENSMUST00000196089.2 NR_030575 uc012hje.1 uc012hje.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012hje.1 uc012hje.2 
ENSMUST00000196091.2 Gm40055 ENSMUST00000196091.2 Gm40055 (from geneSymbol) AK047642 ENSMUST00000196091.1 uc290fla.1 uc290fla.2 uc290fla.1 uc290fla.2 
ENSMUST00000196101.2 Gm43048 ENSMUST00000196101.2 Gm43048 (from geneSymbol) AK080530 ENSMUST00000196101.1 uc290vkn.1 uc290vkn.2 uc290vkn.1 uc290vkn.2 
ENSMUST00000196102.2 4930554G22Rik ENSMUST00000196102.2 4930554G22Rik (from geneSymbol) AK016118 ENSMUST00000196102.1 uc290ipj.1 uc290ipj.2 uc290ipj.1 uc290ipj.2 
ENSMUST00000196105.2 Trav13n-4 ENSMUST00000196105.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A0G2JG01) A0A0G2JG01 A0A0G2JG01_MOUSE ENSMUST00000196105.1 M20876 Trav13n-4 uc288tzt.1 uc288tzt.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc288tzt.1 uc288tzt.2 
ENSMUST00000196108.2 Gm42946 ENSMUST00000196108.2 Gm42946 (from geneSymbol) AB352568 ENSMUST00000196108.1 uc290kut.1 uc290kut.2 uc290kut.1 uc290kut.2 
ENSMUST00000196110.2 Gm42873 ENSMUST00000196110.2 Gm42873 (from geneSymbol) ENSMUST00000196110.1 uc290jus.1 uc290jus.2 uc290jus.1 uc290jus.2 
ENSMUST00000196116.2 Gm42996 ENSMUST00000196116.2 Gm42996 (from geneSymbol) AK042685 ENSMUST00000196116.1 uc291ahy.1 uc291ahy.2 uc291ahy.1 uc291ahy.2 
ENSMUST00000196117.2 Gm42701 ENSMUST00000196117.2 Gm42701 (from geneSymbol) AK142739 ENSMUST00000196117.1 uc290iif.1 uc290iif.2 uc290iif.1 uc290iif.2 
ENSMUST00000196121.2 Gm43552 ENSMUST00000196121.2 Gm43552 (from geneSymbol) A0A0G2JGR2 A0A0G2JGR2_MOUSE AK018994 ENSMUST00000196121.1 Gm43552 uc290vwf.1 uc290vwf.2 uc290vwf.1 uc290vwf.2 
ENSMUST00000196136.2 Gm42683 ENSMUST00000196136.2 Gm42683 (from geneSymbol) ENSMUST00000196136.1 uc288lcl.1 uc288lcl.2 uc288lcl.1 uc288lcl.2 
ENSMUST00000196145.5 Gm43391 ENSMUST00000196145.5 Gm43391 (from geneSymbol) AK016255 ENSMUST00000196145.1 ENSMUST00000196145.2 ENSMUST00000196145.3 ENSMUST00000196145.4 uc290tgl.1 uc290tgl.2 uc290tgl.1 uc290tgl.2 
ENSMUST00000196150.2 Gm43731 ENSMUST00000196150.2 Gm43731 (from geneSymbol) ENSMUST00000196150.1 uc290jjt.1 uc290jjt.2 uc290jjt.1 uc290jjt.2 
ENSMUST00000196157.3 Mir451b ENSMUST00000196157.3 microRNA 451b (from RefSeq NR_105850.1) ENSMUST00000196157.1 ENSMUST00000196157.2 NR_105850 uc033fyl.1 uc033fyl.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609032.1 [ECO:0000345] ##Evidence-Data-END## uc033fyl.1 uc033fyl.2 
ENSMUST00000196183.2 Gm43839 ENSMUST00000196183.2 Gm43839 (from geneSymbol) AK157149 ENSMUST00000196183.1 uc290gck.1 uc290gck.2 uc290gck.1 uc290gck.2 
ENSMUST00000196186.2 Gm43556 ENSMUST00000196186.2 Gm43556 (from geneSymbol) AK157613 ENSMUST00000196186.1 uc291bje.1 uc291bje.2 uc291bje.1 uc291bje.2 
ENSMUST00000196190.3 Gm43539 ENSMUST00000196190.3 Gm43539 (from geneSymbol) ENSMUST00000196190.1 ENSMUST00000196190.2 uc290euq.1 uc290euq.2 uc290euq.3 uc290euq.1 uc290euq.2 uc290euq.3 
ENSMUST00000196191.2 Gm43829 ENSMUST00000196191.2 Gm43829 (from geneSymbol) ENSMUST00000196191.1 uc290vjt.1 uc290vjt.2 uc290vjt.1 uc290vjt.2 
ENSMUST00000196193.2 Gm42499 ENSMUST00000196193.2 Gm42499 (from geneSymbol) ENSMUST00000196193.1 uc291abd.1 uc291abd.2 uc291abd.1 uc291abd.2 
ENSMUST00000196199.3 Mir292b ENSMUST00000196199.3 microRNA 292b (from RefSeq NR_106140.1) ENSMUST00000196199.1 ENSMUST00000196199.2 NR_106140 uc033ivy.1 uc033ivy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ivy.1 uc033ivy.2 
ENSMUST00000196201.2 Igkv4-71 ENSMUST00000196201.2 Igkv4-71 (from geneSymbol) A0A0G2JEH0 A0A0G2JEH0_MOUSE DQ372800 ENSMUST00000196201.1 Igkv4-71 uc291fkl.1 uc291fkl.2 immunoglobulin production molecular_function extracellular space immune response uc291fkl.1 uc291fkl.2 
ENSMUST00000196210.3 Mir191 ENSMUST00000196210.3 microRNA 191 (from RefSeq NR_029577.1) ENSMUST00000196210.1 ENSMUST00000196210.2 NR_029577 uc292lhd.1 uc292lhd.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608313.1 [ECO:0000345] ##Evidence-Data-END## uc292lhd.1 uc292lhd.2 
ENSMUST00000196214.2 Gm21663 ENSMUST00000196214.2 predicted gene, 21663 (from RefSeq NM_001378637.1) A0A0G2JE01 A0A0G2JE01_MOUSE ENSMUST00000196214.1 Gm21663 NM_001378637 uc290tuu.1 uc290tuu.2 uc290tuu.1 uc290tuu.2 
ENSMUST00000196216.2 Gm42413 ENSMUST00000196216.2 Gm42413 (from geneSymbol) ENSMUST00000196216.1 uc290vgs.1 uc290vgs.2 uc290vgs.1 uc290vgs.2 
ENSMUST00000196219.2 Gm43652 ENSMUST00000196219.2 Gm43652 (from geneSymbol) ENSMUST00000196219.1 uc290joq.1 uc290joq.2 uc290joq.1 uc290joq.2 
ENSMUST00000196221.2 Trdd1 ENSMUST00000196221.2 Trdd1 (from geneSymbol) ENSMUST00000196221.1 uc288ubu.1 uc288ubu.2 uc288ubu.1 uc288ubu.2 
ENSMUST00000196227.2 Gm42892 ENSMUST00000196227.2 Gm42892 (from geneSymbol) ENSMUST00000196227.1 uc290jbg.1 uc290jbg.2 uc290jbg.1 uc290jbg.2 
ENSMUST00000196228.2 Gm43120 ENSMUST00000196228.2 Gm43120 (from geneSymbol) ENSMUST00000196228.1 uc290hzv.1 uc290hzv.2 uc290hzv.1 uc290hzv.2 
ENSMUST00000196232.2 Gm43322 ENSMUST00000196232.2 Gm43322 (from geneSymbol) ENSMUST00000196232.1 uc290jmk.1 uc290jmk.2 uc290jmk.1 uc290jmk.2 
ENSMUST00000196235.2 Gm43411 ENSMUST00000196235.2 Gm43411 (from geneSymbol) ENSMUST00000196235.1 uc290zmt.1 uc290zmt.2 uc290zmt.1 uc290zmt.2 
ENSMUST00000196236.3 Mir6516 ENSMUST00000196236.3 microRNA 6516 (from RefSeq NR_105853.1) ENSMUST00000196236.1 ENSMUST00000196236.2 NR_105853 uc033gbn.1 uc033gbn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gbn.1 uc033gbn.2 
ENSMUST00000196237.2 Gm42905 ENSMUST00000196237.2 Gm42905 (from geneSymbol) ENSMUST00000196237.1 uc290iwh.1 uc290iwh.2 uc290iwh.1 uc290iwh.2 
ENSMUST00000196238.2 Gm42680 ENSMUST00000196238.2 Gm42680 (from geneSymbol) ENSMUST00000196238.1 uc290tfb.1 uc290tfb.2 uc290tfb.1 uc290tfb.2 
ENSMUST00000196239.2 Ctxnd2 ENSMUST00000196239.2 cortexin domain containing 2 (from RefSeq NM_001384190.1) A0A1B0GQX3 CTXD2_MOUSE Ctxnd2 ENSMUST00000196239.1 NM_001384190 uc290hpb.1 uc290hpb.2 Membrane ; Single-pass membrane protein membrane integral component of membrane uc290hpb.1 uc290hpb.2 
ENSMUST00000196242.2 1600023N17Rik ENSMUST00000196242.2 RIKEN cDNA 1600023N17 gene (from RefSeq NR_073433.1) ENSMUST00000196242.1 NR_073433 uc033ijm.1 uc033ijm.2 uc033ijm.3 uc033ijm.1 uc033ijm.2 uc033ijm.3 
ENSMUST00000196252.3 Mir7231 ENSMUST00000196252.3 microRNA 7231 (from RefSeq NR_106090.1) ENSMUST00000196252.1 ENSMUST00000196252.2 NR_106090 uc033iun.1 uc033iun.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033iun.1 uc033iun.2 
ENSMUST00000196253.2 Gm43379 ENSMUST00000196253.2 Gm43379 (from geneSymbol) AK038493 ENSMUST00000196253.1 uc290jxh.1 uc290jxh.2 uc290jxh.1 uc290jxh.2 
ENSMUST00000196275.2 Gm43218 ENSMUST00000196275.2 Gm43218 (from geneSymbol) A0A0G2JGT0 A0A0G2JGT0_MOUSE ENSMUST00000196275.1 Gm43218 uc291fno.1 uc291fno.2 immunoglobulin production extracellular space immune response uc291fno.1 uc291fno.2 
ENSMUST00000196277.2 Gm42518 ENSMUST00000196277.2 Gm42518 (from geneSymbol) AK078201 ENSMUST00000196277.1 uc290xym.1 uc290xym.2 uc290xym.1 uc290xym.2 
ENSMUST00000196278.3 Gm42161 ENSMUST00000196278.3 Gm42161 (from geneSymbol) ENSMUST00000196278.1 ENSMUST00000196278.2 uc290ylf.1 uc290ylf.2 uc290ylf.3 uc290ylf.1 uc290ylf.2 uc290ylf.3 
ENSMUST00000196282.5 Zcchc8 ENSMUST00000196282.5 zinc finger, CCHC domain containing 8 (from RefSeq NM_027494.3) ENSMUST00000196282.1 ENSMUST00000196282.2 ENSMUST00000196282.3 ENSMUST00000196282.4 NM_027494 Q3TK71 Q8CCB7 Q91WQ1 Q9CYA6 ZCHC8_MOUSE uc057lnz.1 uc057lnz.2 uc057lnz.3 Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing. It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function. Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Identified in the spliceosome C complex. Component of the nuclear exosome targeting (NEXT) complex composed of MTREX, ZCCHC8, and RBM7 that directs a subset of non-coding short-lived RNAs for exosomal degradation. Interacts with proteins involved in RNA processing and degradation such as MTREX and RBM7; interaction with MTREX enhances MTREX RNA helicase activity and bridges between RBM7 and MTREX. Interacts with TERC, the telomerase RNA component. Nucleus, nucleoplasm Note=Excluded from nucleolus. The C-terminal part (659-707) contributes to MTREX RNA helicase activity, in part, by enhancing its RNA-dependent ATPase activity. Phosphorylation at Thr-495 by GSK3 is triggered in cells entering mitosis. ZCCHC8-null mice have a small brain volume, cranial deformities with domed-shaped heads, and severe hydrocephalus with ventriculomegaly. Defective turnover of low abundance RNA polymerase II transcripts is detected in developing brain of knockout animals. Belongs to the ZCCHC8 family. nucleic acid binding nucleus nucleoplasm spliceosomal complex mRNA processing biological_process zinc ion binding RNA splicing nuclear body TRAMP complex metal ion binding catalytic step 2 spliceosome uc057lnz.1 uc057lnz.2 uc057lnz.3 
ENSMUST00000196286.2 4930597L12Rik ENSMUST00000196286.2 4930597L12Rik (from geneSymbol) ENSMUST00000196286.1 uc290krm.1 uc290krm.2 uc290krm.1 uc290krm.2 
ENSMUST00000196287.2 Gm42979 ENSMUST00000196287.2 Gm42979 (from geneSymbol) ENSMUST00000196287.1 uc291acl.1 uc291acl.2 uc291acl.1 uc291acl.2 
ENSMUST00000196294.2 Gm43601 ENSMUST00000196294.2 Gm43601 (from geneSymbol) AK139721 ENSMUST00000196294.1 uc290vie.1 uc290vie.2 uc290vie.1 uc290vie.2 
ENSMUST00000196295.2 Gm43216 ENSMUST00000196295.2 Gm43216 (from geneSymbol) ENSMUST00000196295.1 uc290tjr.1 uc290tjr.2 uc290tjr.1 uc290tjr.2 
ENSMUST00000196296.2 Asic3 ENSMUST00000196296.2 acid-sensing ion channel 3, transcript variant 1 (from RefSeq NM_183000.2) ASIC3_MOUSE Accn3 Drasic ENSMUST00000196296.1 NM_183000 Q6X1Y6 Q7TQH4 uc008wrj.1 uc008wrj.2 uc008wrj.3 Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with DLG4 and ASIC2 (By similarity). Interacts with LIN7B, MAGI1/BAIAP1 and GOPC. Interacts with STOM; this regulates channel activity. Cell membrane ; Multi-pass membrane protein Cytoplasm Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4 (By similarity). In part cytoplasmic in cochlea cells. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6X1Y6-1; Sequence=Displayed; Name=2; IsoId=Q6X1Y6-2; Sequence=VSP_015606, VSP_015607; Expressed in liver, lung, kidney, testis, brain, eye and cochlea. Expressed in spiral ganglion and sensory hair cells of the organ of Corti in the cochlea (at protein level). Expressed in dorsal root ganglion innervating muscles and spinal chord. Expressed in peripheral sensory nerve termimals like nerves of the Meissner corpuscle, palisades of lanceolate nerve endings, site of mechanoreception in guard hair follicles, and Merkel cell-neurite complexes. Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ASIC3/ACCN3-ASIC2/ASIC2b channel, but does not activate a homomeric ASIC3/ACCN3 channel (By similarity). Mice display altered responses to mechanical and acid stimuli. They do not develop chronic hyperalgesia induced by repeated acid injection. Sensitized and potentiated by NPFF and NPSF. Inhibited by anti-inflammatory drugs, like salicylic acid (By similarity). Potentiated by FMRFamide-related neuropeptides. Regulated by lactate and Ca(2+). Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. cation channel activity sodium channel activity cytoplasm plasma membrane integral component of plasma membrane ion transport cation transport sodium ion transport response to heat response to mechanical stimulus response to acidic pH ligand-gated sodium channel activity membrane integral component of membrane ion transmembrane transport sodium ion transmembrane transport enterobactin transport enterobactin transporter activity perinuclear region of cytoplasm detection of chemical stimulus involved in sensory perception sensory perception of sour taste detection of temperature stimulus involved in sensory perception detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain detection of chemical stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception cation transmembrane transport uc008wrj.1 uc008wrj.2 uc008wrj.3 
ENSMUST00000196302.2 Gm43062 ENSMUST00000196302.2 Gm43062 (from geneSymbol) AK136378 ENSMUST00000196302.1 uc290ifb.1 uc290ifb.2 uc290ifb.1 uc290ifb.2 
ENSMUST00000196303.2 Gm43765 ENSMUST00000196303.2 Gm43765 (from geneSymbol) AK141518 ENSMUST00000196303.1 uc290jml.1 uc290jml.2 uc290jml.1 uc290jml.2 
ENSMUST00000196305.3 Gm42596 ENSMUST00000196305.3 Gm42596 (from geneSymbol) AK038433 ENSMUST00000196305.1 ENSMUST00000196305.2 uc290yfl.1 uc290yfl.2 uc290yfl.3 uc290yfl.1 uc290yfl.2 uc290yfl.3 
ENSMUST00000196307.2 Gm43715 ENSMUST00000196307.2 Gm43715 (from geneSymbol) ENSMUST00000196307.1 uc290vqm.1 uc290vqm.2 uc290vqm.1 uc290vqm.2 
ENSMUST00000196308.6 Gm3143 ENSMUST00000196308.6 predicted gene 3143, transcript variant 2 (from RefSeq NR_038347.1) ENSMUST00000196308.1 ENSMUST00000196308.2 ENSMUST00000196308.3 ENSMUST00000196308.4 ENSMUST00000196308.5 NR_038347 uc029ula.1 uc029ula.2 uc029ula.3 uc029ula.4 uc029ula.1 uc029ula.2 uc029ula.3 uc029ula.4 
ENSMUST00000196313.3 Gm43672 ENSMUST00000196313.3 Gm43672 (from geneSymbol) ENSMUST00000196313.1 ENSMUST00000196313.2 uc290eck.1 uc290eck.2 uc290eck.3 uc290eck.1 uc290eck.2 uc290eck.3 
ENSMUST00000196314.3 Mir465d ENSMUST00000196314.3 microRNA 465d (from RefSeq NR_106148.1) ENSMUST00000196314.1 ENSMUST00000196314.2 NR_106148 uc033jqi.1 uc033jqi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jqi.1 uc033jqi.2 
ENSMUST00000196323.2 Trdc ENSMUST00000196323.2 Trdc (from geneSymbol) A0A0G2JEU3 A0A0G2JEU3_MOUSE AK040154 ENSMUST00000196323.1 Trdc uc288ucb.1 uc288ucb.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288ucb.1 uc288ucb.2 
ENSMUST00000196326.3 Gm26265 ENSMUST00000196326.3 Gm26265 (from geneSymbol) ENSMUST00000196326.1 ENSMUST00000196326.2 uc292clz.1 uc292clz.2 uc292clz.1 uc292clz.2 
ENSMUST00000196327.2 Gm43774 ENSMUST00000196327.2 Gm43774 (from geneSymbol) AK039353 ENSMUST00000196327.1 uc290hjj.1 uc290hjj.2 uc290hjj.1 uc290hjj.2 
ENSMUST00000196328.2 Gm42843 ENSMUST00000196328.2 Gm42843 (from geneSymbol) ENSMUST00000196328.1 uc290fjq.1 uc290fjq.2 uc290fjq.1 uc290fjq.2 
ENSMUST00000196332.2 Gm42708 ENSMUST00000196332.2 Gm42708 (from geneSymbol) AK053324 ENSMUST00000196332.1 uc290kgp.1 uc290kgp.2 uc290kgp.1 uc290kgp.2 
ENSMUST00000196334.3 Mir216c ENSMUST00000196334.3 microRNA 216c (from RefSeq NR_106152.1) ENSMUST00000196334.1 ENSMUST00000196334.2 NR_106152 uc033fue.1 uc033fue.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fue.1 uc033fue.2 
ENSMUST00000196359.3 Mir1839 ENSMUST00000196359.3 microRNA 1839 (from RefSeq NR_035501.1) ENSMUST00000196359.1 ENSMUST00000196359.2 NR_035501 uc012fnx.1 uc012fnx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610503.1 [ECO:0000345] ##Evidence-Data-END## uc012fnx.1 uc012fnx.2 
ENSMUST00000196372.2 Gm10484 ENSMUST00000196372.2 Gm10484 (from geneSymbol) ENSMUST00000196372.1 uc290svx.1 uc290svx.2 uc290svx.1 uc290svx.2 
ENSMUST00000196377.2 Gm43736 ENSMUST00000196377.2 Gm43736 (from geneSymbol) ENSMUST00000196377.1 uc290hed.1 uc290hed.2 uc290hed.1 uc290hed.2 
ENSMUST00000196382.2 Gm43350 ENSMUST00000196382.2 Gm43350 (from geneSymbol) AK080213 ENSMUST00000196382.1 uc290jsq.1 uc290jsq.2 uc290jsq.1 uc290jsq.2 
ENSMUST00000196383.3 Mir290b ENSMUST00000196383.3 microRNA 290b (from RefSeq NR_106158.1) ENSMUST00000196383.1 ENSMUST00000196383.2 NR_106158 uc033ivx.1 uc033ivx.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ivx.1 uc033ivx.2 
ENSMUST00000196384.2 Gm21190 ENSMUST00000196384.2 predicted gene, 21190 (from RefSeq NM_001310449.1) A0A0G2JGJ6 A0A0G2JGJ6_MOUSE ENSMUST00000196384.1 Gm21190 NM_001310449 uc029vfz.1 uc029vfz.2 uc029vfz.3 uc029vfz.1 uc029vfz.2 uc029vfz.3 
ENSMUST00000196390.2 Gm42553 ENSMUST00000196390.2 Gm42553 (from geneSymbol) AB349574 ENSMUST00000196390.1 uc290vcy.1 uc290vcy.2 uc290vcy.1 uc290vcy.2 
ENSMUST00000196396.2 Gm42423 ENSMUST00000196396.2 Gm42423 (from geneSymbol) ENSMUST00000196396.1 uc291bgv.1 uc291bgv.2 uc291bgv.1 uc291bgv.2 
ENSMUST00000196407.2 Gm42970 ENSMUST00000196407.2 Gm42970 (from geneSymbol) AK149016 ENSMUST00000196407.1 uc290jnc.1 uc290jnc.2 uc290jnc.1 uc290jnc.2 
ENSMUST00000196415.2 Gm43474 ENSMUST00000196415.2 Gm43474 (from geneSymbol) ENSMUST00000196415.1 uc291aaq.1 uc291aaq.2 uc291aaq.1 uc291aaq.2 
ENSMUST00000196422.2 Gm43397 ENSMUST00000196422.2 Gm43397 (from geneSymbol) ENSMUST00000196422.1 uc291bmz.1 uc291bmz.2 uc291bmz.1 uc291bmz.2 
ENSMUST00000196427.2 C030032O16Rik ENSMUST00000196427.2 C030032O16Rik (from geneSymbol) AK021115 ENSMUST00000196427.1 uc290iih.1 uc290iih.2 uc290iih.1 uc290iih.2 
ENSMUST00000196431.2 Gm43486 ENSMUST00000196431.2 Gm43486 (from geneSymbol) ENSMUST00000196431.1 uc290kxk.1 uc290kxk.2 uc290kxk.1 uc290kxk.2 
ENSMUST00000196434.2 Gm35394 ENSMUST00000196434.2 Gm35394 (from geneSymbol) ENSMUST00000196434.1 uc290xju.1 uc290xju.2 uc290xju.1 uc290xju.2 
ENSMUST00000196438.3 2010110G14Rik ENSMUST00000196438.3 2010110G14Rik (from geneSymbol) AK008379 ENSMUST00000196438.1 ENSMUST00000196438.2 uc290jsl.1 uc290jsl.2 uc290jsl.1 uc290jsl.2 
ENSMUST00000196439.2 Gm43562 ENSMUST00000196439.2 Gm43562 (from geneSymbol) ENSMUST00000196439.1 uc291bqu.1 uc291bqu.2 uc291bqu.1 uc291bqu.2 
ENSMUST00000196442.2 Gm43135 ENSMUST00000196442.2 Gm43135 (from geneSymbol) AK029132 ENSMUST00000196442.1 uc290ici.1 uc290ici.2 uc290ici.1 uc290ici.2 
ENSMUST00000196451.2 Gm43707 ENSMUST00000196451.2 Gm43707 (from geneSymbol) ENSMUST00000196451.1 uc290khc.1 uc290khc.2 uc290khc.1 uc290khc.2 
ENSMUST00000196456.5 Rbm8a ENSMUST00000196456.5 RNA binding motif protein 8a, transcript variant 1 (from RefSeq NM_001102407.1) A0A023T672 ENSMUST00000196456.1 ENSMUST00000196456.2 ENSMUST00000196456.3 ENSMUST00000196456.4 NM_001102407 Q3UT38 Q6GTD4 Q9CWZ3 Q9D6U5 RBM8A_MOUSE Rbm8 uc008qnl.1 uc008qnl.2 uc008qnl.3 uc008qnl.4 Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity). Heterodimer with either MAGOH or MAGOHB. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A. Interacts with PYM1; the interaction is direct and dissociates the EJC from spliced mRNAs. Part of a complex that contains the EJC core components CASC3, EIF4A3, MAGOH and RBM8A plus proteins involved in nonsense- mediated mRNA decay, such as UPF1, UPF2, UPF3A and UPF3B. Found in a post-splicing complex with NXF1, MAGOH, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Interacts with DDX39B, MAGOH, DPH1, UPF3B, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with IPO13; the interaction mediates the nuclear import of the MAGOH-RBM8A heterodimer. Identified in the spliceosome C complex. Associates with polysomes. Nucleus Nucleus speckle Cytoplasm Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CWZ3-1; Sequence=Displayed; Name=2; IsoId=Q9CWZ3-2; Sequence=VSP_010251; Belongs to the RBM8A family. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding nucleus spliceosomal complex cytoplasm RNA processing mRNA processing regulation of translation RNA splicing nuclear speck dendrite exon-exon junction complex neuronal cell body mRNA transport U2-type catalytic step 1 spliceosome catalytic step 2 spliceosome uc008qnl.1 uc008qnl.2 uc008qnl.3 uc008qnl.4 
ENSMUST00000196459.2 Gm43817 ENSMUST00000196459.2 Gm43817 (from geneSymbol) AK135412 ENSMUST00000196459.1 uc290xtg.1 uc290xtg.2 uc290xtg.1 uc290xtg.2 
ENSMUST00000196460.2 Gm43525 ENSMUST00000196460.2 Gm43525 (from geneSymbol) ENSMUST00000196460.1 uc290ebv.1 uc290ebv.2 uc290ebv.1 uc290ebv.2 
ENSMUST00000196463.2 Gm43238 ENSMUST00000196463.2 Gm43238 (from geneSymbol) ENSMUST00000196463.1 uc290vry.1 uc290vry.2 uc290vry.1 uc290vry.2 
ENSMUST00000196466.4 Snhg8 ENSMUST00000196466.4 Snhg8 (from geneSymbol) BC096391 ENSMUST00000196466.1 ENSMUST00000196466.2 ENSMUST00000196466.3 uc008rfm.1 uc008rfm.2 uc008rfm.3 uc008rfm.4 uc008rfm.5 uc008rfm.1 uc008rfm.2 uc008rfm.3 uc008rfm.4 uc008rfm.5 
ENSMUST00000196468.2 Gm42991 ENSMUST00000196468.2 Gm42991 (from geneSymbol) ENSMUST00000196468.1 uc291ahq.1 uc291ahq.2 uc291ahq.1 uc291ahq.2 
ENSMUST00000196470.2 Gm42510 ENSMUST00000196470.2 Gm42510 (from geneSymbol) ENSMUST00000196470.1 uc290jjp.1 uc290jjp.2 uc290jjp.1 uc290jjp.2 
ENSMUST00000196474.2 Gm43544 ENSMUST00000196474.2 Gm43544 (from geneSymbol) ENSMUST00000196474.1 LF192901 uc287mft.1 uc287mft.2 uc287mft.1 uc287mft.2 
ENSMUST00000196478.6 Dmrt1i ENSMUST00000196478.6 Dmrt1 interacting ncRNA, transcript variant a (from RefSeq NR_102372.1) ENSMUST00000196478.1 ENSMUST00000196478.2 ENSMUST00000196478.3 ENSMUST00000196478.4 ENSMUST00000196478.5 NR_102372 uc033int.1 uc033int.2 uc033int.3 This gene is involved in trans-splicing (PMID 20816665) with a functional gene on chromosome 19, Dmrt1 (Dsx- and Mab3-related transcription factor-1), which plays a role in male sexual development. Dmr mainly forms the 3' UTR in the resulting transcript and provides a stop codon, resulting in a truncated Dmrt1 protein. Trans-splicing involving this gene is suggested to serve as a mechanism of negative regulation of Dmrt1 function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2013]. uc033int.1 uc033int.2 uc033int.3 
ENSMUST00000196483.5 Fbxl5 ENSMUST00000196483.5 F-box and leucine-rich repeat protein 5, transcript variant 22 (from RefSeq NR_188803.1) ENSMUST00000196483.1 ENSMUST00000196483.2 ENSMUST00000196483.3 ENSMUST00000196483.4 FBXL5_MOUSE NR_188803 Q14CG1 Q3TAK6 Q3TWC9 Q3UC66 Q80XI5 Q8BGF5 Q8BNL3 Q8C2S5 Q8C3Q8 uc008xhv.1 uc008xhv.2 uc008xhv.3 uc008xhv.4 Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2 (PubMed:21907140, PubMed:23135277). The C-terminal domain of FBXL5 contains a redox-sensitive [2Fe-2S] cluster that, upon oxidation, promotes binding to IRP2 to effect its oxygen-dependent degradation. Under iron deficiency conditions, the N-terminal hemerythrin-like (Hr) region, which contains a diiron metal center, cannot bind iron and undergoes conformational changes that destabilize the FBXL5 protein and cause its ubiquitination and degradation. When intracellular iron levels start rising, the Hr region is stabilized. Additional increases in iron levels facilitate the assembly and incorporation of a redox active [2Fe-2S] cluster in the C-terminal domain. Only when oxygen level is high enough to maintain the cluster in its oxidized state can FBXL5 recruit IRP2 as a substrate for polyubiquination and degradation. Promotes ubiquitination and subsequent degradation of the dynactin complex component DCTN1. Within the nucleus, promotes the ubiquitination of SNAI1; preventing its interaction with DNA and promoting its degradation. Negatively regulates DNA damage response by mediating the ubiquitin-proteasome degradation of the DNA repair protein NABP2 (By similarity). Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; An iron-sulfur cluster promotes IRP2 polyubiquitination and degradation in response to both iron and oxygen concentrations. Protein modification; protein ubiquitination. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with ACO1/IRP1, IREB2/IRP2; the interaction depends on the [2Fe-2S] cluster. Interacts with DCTN1/p150-glued. Cytoplasm, perinuclear region Nucleus Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8C2S5-1; Sequence=Displayed; Name=2; IsoId=Q8C2S5-2; Sequence=VSP_008418; Name=3; IsoId=Q8C2S5-3; Sequence=VSP_008419, VSP_008420; Name=4; IsoId=Q8C2S5-4; Sequence=VSP_038530; Name=5; IsoId=Q8C2S5-5; Sequence=VSP_038529, VSP_008419, VSP_008420; Ubiquitously expressed. Highly expressed in early embryogenesis with expression decreasing as the embryo progresses through development (E11 and E15). The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded (By similarity). Polybiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor. Undergoes constitutive ubiquitin-dependent degradation at the steady state by HERC2. FBXL5-deletion mice die during early embryogenesis (PubMed:23135277, PubMed:21907140). FBXL5-null embryos accumulate excess ferrous iron and are exposed to damaging levels of oxidative stress (PubMed:21907140). Simultaneous inactivation of both the FBXL5 and IRP2 genes is sufficient to rescue embryonic lethality (PubMed:21907140). iron ion binding cytoplasm ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process metal ion binding perinuclear region of cytoplasm iron ion homeostasis positive regulation of cellular protein catabolic process ubiquitin-protein transferase activity uc008xhv.1 uc008xhv.2 uc008xhv.3 uc008xhv.4 
ENSMUST00000196484.2 4930477O15Rik ENSMUST00000196484.2 4930477O15Rik (from geneSymbol) AK015582 ENSMUST00000196484.1 uc290zfl.1 uc290zfl.2 uc290zfl.1 uc290zfl.2 
ENSMUST00000196486.2 Gm34086 ENSMUST00000196486.2 Gm34086 (from geneSymbol) ENSMUST00000196486.1 uc290zsv.1 uc290zsv.2 uc290zsv.1 uc290zsv.2 
ENSMUST00000196492.3 Gm42860 ENSMUST00000196492.3 Gm42860 (from geneSymbol) AK215715 ENSMUST00000196492.1 ENSMUST00000196492.2 uc290vrq.1 uc290vrq.2 uc290vrq.1 uc290vrq.2 
ENSMUST00000196502.3 Mir7646 ENSMUST00000196502.3 microRNA 7646 (from RefSeq NR_106104.1) ENSMUST00000196502.1 ENSMUST00000196502.2 NR_106104 uc292qpi.1 uc292qpi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc292qpi.1 uc292qpi.2 
ENSMUST00000196503.2 Gm42838 ENSMUST00000196503.2 Gm42838 (from geneSymbol) ENSMUST00000196503.1 uc290zya.1 uc290zya.2 uc290zya.1 uc290zya.2 
ENSMUST00000196510.2 Gm43780 ENSMUST00000196510.2 Gm43780 (from geneSymbol) AB351293 ENSMUST00000196510.1 uc290vpj.1 uc290vpj.2 uc290vpj.1 uc290vpj.2 
ENSMUST00000196511.2 Irs3 ENSMUST00000196511.2 Irs3 (from geneSymbol) BC098235 ENSMUST00000196511.1 Irs3 Q4QQK2 Q4QQK2_MOUSE uc009adi.1 uc009adi.2 uc009adi.3 insulin receptor binding cytosol plasma membrane insulin receptor signaling pathway intracellular membrane-bounded organelle phosphatidylinositol 3-kinase binding uc009adi.1 uc009adi.2 uc009adi.3 
ENSMUST00000196513.2 Gm43430 ENSMUST00000196513.2 Gm43430 (from geneSymbol) ENSMUST00000196513.1 LF204581 uc290jyo.1 uc290jyo.2 uc290jyo.1 uc290jyo.2 
ENSMUST00000196515.2 Gm42494 ENSMUST00000196515.2 Gm42494 (from geneSymbol) ENSMUST00000196515.1 uc292lmo.1 uc292lmo.2 uc292lmo.1 uc292lmo.2 
ENSMUST00000196517.2 Gm42744 ENSMUST00000196517.2 Gm42744 (from geneSymbol) AK053423 ENSMUST00000196517.1 uc290svf.1 uc290svf.2 uc290svf.1 uc290svf.2 
ENSMUST00000196520.2 Gbp6 ENSMUST00000196520.2 guanylate binding protein 6 (from RefSeq NM_194336.2) A0A8Q0QEH4 A0A8Q0QEH4_MOUSE ENSMUST00000196520.1 Gbp6 NM_194336 uc012eag.1 uc012eag.2 uc012eag.3 Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. uc012eag.1 uc012eag.2 uc012eag.3 
ENSMUST00000196522.2 Gm43365 ENSMUST00000196522.2 Gm43365 (from geneSymbol) ENSMUST00000196522.1 uc290xzi.1 uc290xzi.2 uc290xzi.1 uc290xzi.2 
ENSMUST00000196532.2 Gm43836 ENSMUST00000196532.2 Gm43836 (from geneSymbol) AK198190 ENSMUST00000196532.1 uc290vto.1 uc290vto.2 uc290vto.1 uc290vto.2 
ENSMUST00000196534.3 Gm42141 ENSMUST00000196534.3 Gm42141 (from geneSymbol) AK144133 ENSMUST00000196534.1 ENSMUST00000196534.2 uc290xsl.1 uc290xsl.2 uc290xsl.3 uc290xsl.1 uc290xsl.2 uc290xsl.3 
ENSMUST00000196538.2 Gm32693 ENSMUST00000196538.2 predicted gene, 32693 (from RefSeq NR_153353.1) ENSMUST00000196538.1 NR_153353 uc290kdn.1 uc290kdn.2 uc290kdn.1 uc290kdn.2 
ENSMUST00000196539.2 Gm43753 ENSMUST00000196539.2 Gm43753 (from geneSymbol) AK040499 ENSMUST00000196539.1 uc290vsd.1 uc290vsd.2 uc290vsd.1 uc290vsd.2 
ENSMUST00000196543.2 Gm42462 ENSMUST00000196543.2 Gm42462 (from geneSymbol) ENSMUST00000196543.1 LF194939 uc290vdv.1 uc290vdv.2 uc290vdv.1 uc290vdv.2 
ENSMUST00000196545.2 Gm43695 ENSMUST00000196545.2 Gm43695 (from geneSymbol) ENSMUST00000196545.1 uc290ulc.1 uc290ulc.2 uc290ulc.1 uc290ulc.2 
ENSMUST00000196548.2 9430087B13Rik ENSMUST00000196548.2 9430087B13Rik (from geneSymbol) ENSMUST00000196548.1 uc291aad.1 uc291aad.2 uc291aad.1 uc291aad.2 
ENSMUST00000196549.2 Gm43094 ENSMUST00000196549.2 Gm43094 (from geneSymbol) ENSMUST00000196549.1 uc290ylg.1 uc290ylg.2 uc290ylg.1 uc290ylg.2 
ENSMUST00000196551.2 Gm43509 ENSMUST00000196551.2 Gm43509 (from geneSymbol) ENSMUST00000196551.1 uc290vge.1 uc290vge.2 uc290vge.1 uc290vge.2 
ENSMUST00000196557.2 Gm42610 ENSMUST00000196557.2 Gm42610 (from geneSymbol) ENSMUST00000196557.1 uc290jzw.1 uc290jzw.2 uc290jzw.1 uc290jzw.2 
ENSMUST00000196562.2 Gm43361 ENSMUST00000196562.2 Gm43361 (from geneSymbol) ENSMUST00000196562.1 uc290zkw.1 uc290zkw.2 uc290zkw.1 uc290zkw.2 
ENSMUST00000196563.2 Gm43285 ENSMUST00000196563.2 Gm43285 (from geneSymbol) AB351978 ENSMUST00000196563.1 uc290jif.1 uc290jif.2 uc290jif.1 uc290jif.2 
ENSMUST00000196567.2 2900064K03Rik ENSMUST00000196567.2 2900064K03Rik (from geneSymbol) ENSMUST00000196567.1 uc290vks.1 uc290vks.2 uc290vks.1 uc290vks.2 
ENSMUST00000196581.2 Gm10650 ENSMUST00000196581.2 Gm10650 (from geneSymbol) AK156352 ENSMUST00000196581.1 uc290jot.1 uc290jot.2 uc290jot.1 uc290jot.2 
ENSMUST00000196584.2 Gm43398 ENSMUST00000196584.2 Gm43398 (from geneSymbol) AK035765 ENSMUST00000196584.1 uc291bnd.1 uc291bnd.2 uc291bnd.1 uc291bnd.2 
ENSMUST00000196587.5 Ighv1-74 ENSMUST00000196587.5 Ighv1-74 (from geneSymbol) A0A0G2JGK2 A0A0G2JGK2_MOUSE ENSMUST00000196587.1 ENSMUST00000196587.2 ENSMUST00000196587.3 ENSMUST00000196587.4 Ighv1-74 uc288kcn.1 uc288kcn.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kcn.1 uc288kcn.2 
ENSMUST00000196595.2 Igkv4-63 ENSMUST00000196595.2 Igkv4-63 (from geneSymbol) A0A0G2JFU6 A0A0G2JFU6_MOUSE ENSMUST00000196595.1 Igkv4-63 M64623 uc291fkv.1 uc291fkv.2 immunoglobulin production extracellular space immune response uc291fkv.1 uc291fkv.2 
ENSMUST00000196599.2 Igkv8-19 ENSMUST00000196599.2 Igkv8-19 (from geneSymbol) A0A0G2JFN8 A0A0G2JFN8_MOUSE ENSMUST00000196599.1 Igkv8-19 LC522515 uc291fnx.1 uc291fnx.2 immunoglobulin production extracellular space immune response uc291fnx.1 uc291fnx.2 
ENSMUST00000196601.2 Gm42756 ENSMUST00000196601.2 Gm42756 (from geneSymbol) AK034386 ENSMUST00000196601.1 uc292lmt.1 uc292lmt.2 uc292lmt.1 uc292lmt.2 
ENSMUST00000196615.2 Gm43434 ENSMUST00000196615.2 Gm43434 (from geneSymbol) ENSMUST00000196615.1 uc288ubz.1 uc288ubz.2 uc288ubz.1 uc288ubz.2 
ENSMUST00000196621.5 A730020M07Rik ENSMUST00000196621.5 RIKEN cDNA A730020M07 gene, transcript variant 1 (from RefSeq NR_036456.1) ENSMUST00000196621.1 ENSMUST00000196621.2 ENSMUST00000196621.3 ENSMUST00000196621.4 NR_036456 uc008reb.1 uc008reb.2 uc008reb.3 uc008reb.4 uc008reb.5 uc008reb.1 uc008reb.2 uc008reb.3 uc008reb.4 uc008reb.5 
ENSMUST00000196622.3 Mir684-1 ENSMUST00000196622.3 microRNA 684-1 (from RefSeq NR_030454.1) ENSMUST00000196622.1 ENSMUST00000196622.2 NR_030454 uc012byc.1 uc012byc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012byc.1 uc012byc.2 
ENSMUST00000196630.2 Gm42435 ENSMUST00000196630.2 Gm42435 (from geneSymbol) AK090109 ENSMUST00000196630.1 uc290ssl.1 uc290ssl.2 uc290ssl.1 uc290ssl.2 
ENSMUST00000196636.2 Gm42514 ENSMUST00000196636.2 Gm42514 (from geneSymbol) ENSMUST00000196636.1 uc290jlk.1 uc290jlk.2 uc290jlk.1 uc290jlk.2 
ENSMUST00000196639.2 Trav14n-1 ENSMUST00000196639.2 Trav14n-1 (from geneSymbol) A0A075B6B1 A0A075B6B1_MOUSE AK039793 ENSMUST00000196639.1 Trav14d-1 Trav14n-1 uc029sjk.1 uc029sjk.2 uc029sjk.3 uc029sjk.1 uc029sjk.2 uc029sjk.3 
ENSMUST00000196642.2 Gm42830 ENSMUST00000196642.2 Gm42830 (from geneSymbol) ENSMUST00000196642.1 LF195158 uc290zka.1 uc290zka.2 uc290zka.1 uc290zka.2 
ENSMUST00000196645.2 Hgf ENSMUST00000196645.2 hepatocyte growth factor, transcript variant 5 (from RefSeq NM_001289461.1) ENSMUST00000196645.1 HGF_MOUSE NM_001289461 O55027 Q08048 Q53WS5 Q61662 Q64007 Q6LBE6 uc008wnj.1 uc008wnj.2 uc008wnj.3 This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the hepatocyte growth factor alpha and beta chains, which heterodimerize to form the mature active protein. Although this protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Homozygous knockout mice for this gene exhibit embryonic lethality due to impaired development of the placenta and liver. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). Activates MAPK signaling following TMPRSS13 cleavage and activation (By similarity). Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity. Q08048; P08581: MET; Xeno; NbExp=3; IntAct=EBI-15655650, EBI-1039152; Event=Alternative splicing; Named isoforms=3; Name=Long; IsoId=Q08048-1; Sequence=Displayed; Name=Short; IsoId=Q08048-2; Sequence=VSP_005408; Name=NK1; IsoId=Q08048-3; Sequence=VSP_044345, VSP_044346; The single-chain precursor undergoes proteolytic processing by TMPRSS13 resulting in an active two-chain form. Belongs to the peptidase S1 family. Plasminogen subfamily. Has lost two of the three essential catalytic residues and so probably has no enzymatic activity. Sequence=CAA51054.1; Type=Erroneous initiation; Evidence=; activation of MAPK activity cell morphogenesis liver development positive regulation of protein phosphorylation serine-type endopeptidase activity protein binding extracellular region extracellular space proteolysis growth factor activity positive regulation of phosphatidylinositol 3-kinase signaling hyaluronan metabolic process positive regulation of cell migration animal organ regeneration positive regulation of myelination negative regulation of interleukin-6 production positive regulation of interleukin-10 production negative regulation of peptidyl-serine phosphorylation cellular response to hepatocyte growth factor stimulus chemoattractant activity identical protein binding negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of angiogenesis protein heterodimerization activity hepatocyte growth factor receptor signaling pathway epithelial cell proliferation negative regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation positive chemotaxis myoblast proliferation cell chemotaxis regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling positive regulation of neuron projection regeneration negative regulation of release of cytochrome c from mitochondria regulation of p38MAPK cascade negative regulation of hydrogen peroxide-mediated programmed cell death negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of tau-protein kinase activity positive regulation of DNA biosynthetic process uc008wnj.1 uc008wnj.2 uc008wnj.3 
ENSMUST00000196656.2 Gm43611 ENSMUST00000196656.2 Gm43611 (from geneSymbol) ENSMUST00000196656.1 uc290twc.1 uc290twc.2 uc290twc.1 uc290twc.2 
ENSMUST00000196660.2 Gm36266 ENSMUST00000196660.2 predicted gene, 36266 (from RefSeq NR_165817.1) ENSMUST00000196660.1 NR_165817 uc009add.1 uc009add.2 uc009add.1 uc009add.2 
ENSMUST00000196663.2 Gm42597 ENSMUST00000196663.2 Gm42597 (from geneSymbol) AK081825 ENSMUST00000196663.1 uc290sxy.1 uc290sxy.2 uc290sxy.1 uc290sxy.2 
ENSMUST00000196665.2 Gm43112 ENSMUST00000196665.2 Gm43112 (from geneSymbol) ENSMUST00000196665.1 uc290svj.1 uc290svj.2 uc290svj.1 uc290svj.2 
ENSMUST00000196666.2 Gm43526 ENSMUST00000196666.2 Gm43526 (from geneSymbol) AK159030 ENSMUST00000196666.1 uc290kva.1 uc290kva.2 uc290kva.1 uc290kva.2 
ENSMUST00000196669.2 Gm29151 ENSMUST00000196669.2 Gm29151 (from geneSymbol) ENSMUST00000196669.1 uc290iyz.1 uc290iyz.2 uc290iyz.1 uc290iyz.2 
ENSMUST00000196673.2 Gm43475 ENSMUST00000196673.2 Gm43475 (from geneSymbol) ENSMUST00000196673.1 uc290zzz.1 uc290zzz.2 uc290zzz.1 uc290zzz.2 
ENSMUST00000196674.2 Trav12n-2 ENSMUST00000196674.2 Trav12n-2 (from geneSymbol) A0A0G2JF09 A0A0G2JF09_MOUSE AK077765 ENSMUST00000196674.1 Trav12d-2 Trav12n-2 uc288tzb.1 uc288tzb.2 immunoglobulin production extracellular space immune response uc288tzb.1 uc288tzb.2 
ENSMUST00000196684.2 Atp1a3 ENSMUST00000196684.2 ATPase, Na+/K+ transporting, alpha 3 polypeptide, transcript variant 1 (from RefSeq NM_001374627.1) A0A0G2JGX4 A0A0G2JGX4_MOUSE Atp1a3 ENSMUST00000196684.1 NM_001374627 uc291mxg.1 uc291mxg.2 This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Reaction=ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate; Xref=Rhea:RHEA:18353, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.13; Evidence=; Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. nucleotide binding ATP binding ion transport potassium ion transport potassium-transporting ATPase activity membrane integral component of membrane metal ion binding potassium ion transmembrane transport uc291mxg.1 uc291mxg.2 
ENSMUST00000196689.2 Gm30043 ENSMUST00000196689.2 Gm30043 (from geneSymbol) ENSMUST00000196689.1 uc290gej.1 uc290gej.2 uc290gej.1 uc290gej.2 
ENSMUST00000196690.2 Ighv1-71 ENSMUST00000196690.2 Ighv1-71 (from geneSymbol) A0A0G2JFL3 A0A0G2JFL3_MOUSE AB453396 ENSMUST00000196690.1 Ighv1-71 uc288kcg.1 uc288kcg.2 uc288kcg.1 uc288kcg.2 
ENSMUST00000196697.2 Gm43522 ENSMUST00000196697.2 Gm43522 (from geneSymbol) ENSMUST00000196697.1 LF272834 uc290jsk.1 uc290jsk.2 uc290jsk.1 uc290jsk.2 
ENSMUST00000196705.2 Gm43375 ENSMUST00000196705.2 Gm43375 (from geneSymbol) AK050934 ENSMUST00000196705.1 uc290hsg.1 uc290hsg.2 uc290hsg.1 uc290hsg.2 
ENSMUST00000196710.3 Snord3a ENSMUST00000196710.3 small nucleolar RNA, C/D box 3A (from RefSeq NR_002842.2) ENSMUST00000196710.1 ENSMUST00000196710.2 NR_002842 uc057kin.1 uc057kin.2 uc057kin.3 uc057kin.1 uc057kin.2 uc057kin.3 
ENSMUST00000196713.3 4930572K03Rik ENSMUST00000196713.3 4930572K03Rik (from geneSymbol) AK016281 ENSMUST00000196713.1 ENSMUST00000196713.2 uc008zrx.1 uc008zrx.2 uc008zrx.3 uc008zrx.1 uc008zrx.2 uc008zrx.3 
ENSMUST00000196714.2 5330425B07Rik ENSMUST00000196714.2 5330425B07Rik (from geneSymbol) AK019908 ENSMUST00000196714.1 uc290iyt.1 uc290iyt.2 uc290iyt.1 uc290iyt.2 
ENSMUST00000196718.2 Gm42753 ENSMUST00000196718.2 Gm42753 (from geneSymbol) ENSMUST00000196718.1 uc290etv.1 uc290etv.2 uc290etv.1 uc290etv.2 
ENSMUST00000196720.5 A230001M10Rik ENSMUST00000196720.5 A230001M10Rik (from geneSymbol) AK038386 ENSMUST00000196720.1 ENSMUST00000196720.2 ENSMUST00000196720.3 ENSMUST00000196720.4 uc008qru.1 uc008qru.2 uc008qru.1 uc008qru.2 
ENSMUST00000196721.2 Gm43546 ENSMUST00000196721.2 Gm43546 (from geneSymbol) AK156160 ENSMUST00000196721.1 uc290xpz.1 uc290xpz.2 uc290xpz.1 uc290xpz.2 
ENSMUST00000196722.2 4930553I04Rik ENSMUST00000196722.2 4930553I04Rik (from geneSymbol) AK016105 ENSMUST00000196722.1 uc291abi.1 uc291abi.2 uc291abi.1 uc291abi.2 
ENSMUST00000196724.2 Gm43483 ENSMUST00000196724.2 Gm43483 (from geneSymbol) AK048467 ENSMUST00000196724.1 uc291ahi.1 uc291ahi.2 uc291ahi.1 uc291ahi.2 
ENSMUST00000196733.5 Tuft1 ENSMUST00000196733.5 tuftelin 1, transcript variant 2 (from RefSeq NM_001293728.1) ENSMUST00000196733.1 ENSMUST00000196733.2 ENSMUST00000196733.3 ENSMUST00000196733.4 NM_001293728 Q3TAP8 Q3TAP8_MOUSE Tuft1 uc008qgu.1 uc008qgu.2 uc008qgu.3 uc008qgu.4 Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. [provided by RefSeq, Aug 2014]. uc008qgu.1 uc008qgu.2 uc008qgu.3 uc008qgu.4 
ENSMUST00000196737.3 Mirlet7e ENSMUST00000196737.3 microRNA let7e (from RefSeq NR_029730.1) ENSMUST00000196737.1 ENSMUST00000196737.2 NR_029730 uc012alb.1 uc012alb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608559.1 [ECO:0000345] ##Evidence-Data-END## uc012alb.1 uc012alb.2 
ENSMUST00000196743.2 Gm43210 ENSMUST00000196743.2 Gm43210 (from geneSymbol) AK164659 ENSMUST00000196743.1 uc290jrq.1 uc290jrq.2 uc290jrq.1 uc290jrq.2 
ENSMUST00000196744.2 Gm43314 ENSMUST00000196744.2 Gm43314 (from geneSymbol) AK085611 ENSMUST00000196744.1 uc290kvt.1 uc290kvt.2 uc290kvt.1 uc290kvt.2 
ENSMUST00000196745.5 Dclk1 ENSMUST00000196745.5 doublecortin-like kinase 1, transcript variant 12 (from RefSeq NM_001357475.1) A0A0G2JGQ6 A0A0G2JGQ6_MOUSE Dclk1 ENSMUST00000196745.1 ENSMUST00000196745.2 ENSMUST00000196745.3 ENSMUST00000196745.4 NM_001357475 uc012cpp.1 uc012cpp.2 uc012cpp.3 This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. [provided by RefSeq, Sep 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB093234.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; protein kinase activity ATP binding protein phosphorylation intracellular signal transduction uc012cpp.1 uc012cpp.2 uc012cpp.3 
ENSMUST00000196748.2 Gm53046 ENSMUST00000196748.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A0G2JGS1) A0A0G2JGS1 A0A0G2JGS1_MOUSE AK154312 ENSMUST00000196748.1 Gm53046 uc290ilg.1 uc290ilg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane uc290ilg.1 uc290ilg.2 
ENSMUST00000196754.2 Gm42552 ENSMUST00000196754.2 Gm42552 (from geneSymbol) AK089643 ENSMUST00000196754.1 uc290vcz.1 uc290vcz.2 uc290vcz.1 uc290vcz.2 
ENSMUST00000196756.2 Trav7d-6 ENSMUST00000196756.2 Trav7d-6 (from geneSymbol) A0A0B4J1N1 A0A0B4J1N1_MOUSE AK050592 C920008G01Rik ENSMUST00000196756.1 Trav7d-6 Trav7n-6 uc288tya.1 uc288tya.2 molecular_function cellular_component biological_process uc288tya.1 uc288tya.2 
ENSMUST00000196765.2 Gm43545 ENSMUST00000196765.2 Gm43545 (from geneSymbol) ENSMUST00000196765.1 uc290xqq.1 uc290xqq.2 uc290xqq.1 uc290xqq.2 
ENSMUST00000196766.2 Gm43581 ENSMUST00000196766.2 Gm43581 (from geneSymbol) AK153795 ENSMUST00000196766.1 uc290iiz.1 uc290iiz.2 uc290iiz.1 uc290iiz.2 
ENSMUST00000196768.2 Igkv9-124 ENSMUST00000196768.2 Igkv9-124 (from geneSymbol) A0A0G2JDR3 A0A0G2JDR3_MOUSE ENSMUST00000196768.1 Igkv9-124 X02178 uc291fgv.1 uc291fgv.2 immunoglobulin production extracellular space immune response uc291fgv.1 uc291fgv.2 
ENSMUST00000196770.2 Gm43024 ENSMUST00000196770.2 Gm43024 (from geneSymbol) ENSMUST00000196770.1 uc290hzr.1 uc290hzr.2 uc290hzr.1 uc290hzr.2 
ENSMUST00000196771.2 Gm42595 ENSMUST00000196771.2 Gm42595 (from geneSymbol) AK043115 ENSMUST00000196771.1 uc290yga.1 uc290yga.2 uc290yga.1 uc290yga.2 
ENSMUST00000196776.3 Mir6948 ENSMUST00000196776.3 microRNA 6948 (from RefSeq NR_105913.1) ENSMUST00000196776.1 ENSMUST00000196776.2 NR_105913 uc033gqu.1 uc033gqu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gqu.1 uc033gqu.2 
ENSMUST00000196779.2 Gm42693 ENSMUST00000196779.2 Gm42693 (from geneSymbol) AK083619 ENSMUST00000196779.1 uc290eno.1 uc290eno.2 uc290eno.1 uc290eno.2 
ENSMUST00000196796.3 Mir664 ENSMUST00000196796.3 microRNA 664 (from RefSeq NR_035529.1) ENSMUST00000196796.1 ENSMUST00000196796.2 NR_035529 uc287ota.1 uc287ota.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc287ota.1 uc287ota.2 
ENSMUST00000196802.2 Trav14d-2 ENSMUST00000196802.2 Trav14d-2 (from geneSymbol) A0A0G2JDF5 A0A0G2JDF5_MOUSE BC147840 ENSMUST00000196802.1 Trav14d-2 Trav14n-2 uc288txq.1 uc288txq.2 uc288txq.1 uc288txq.2 
ENSMUST00000196805.2 Gm42454 ENSMUST00000196805.2 Gm42454 (from geneSymbol) AK089588 ENSMUST00000196805.1 uc290tgv.1 uc290tgv.2 uc290tgv.1 uc290tgv.2 
ENSMUST00000196806.2 Gm42433 ENSMUST00000196806.2 Gm42433 (from geneSymbol) AK135078 ENSMUST00000196806.1 uc292lof.1 uc292lof.2 uc292lof.1 uc292lof.2 
ENSMUST00000196810.2 Gm43489 ENSMUST00000196810.2 Gm43489 (from geneSymbol) ENSMUST00000196810.1 uc290thm.1 uc290thm.2 uc290thm.1 uc290thm.2 
ENSMUST00000196812.3 Mir7228 ENSMUST00000196812.3 microRNA 7228 (from RefSeq NR_106087.1) ENSMUST00000196812.1 ENSMUST00000196812.2 NR_106087 uc033imp.1 uc033imp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033imp.1 uc033imp.2 
ENSMUST00000196817.5 Rhoc ENSMUST00000196817.5 Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. (from UniProt Q62159) Arhc BC004627 ENSMUST00000196817.1 ENSMUST00000196817.2 ENSMUST00000196817.3 ENSMUST00000196817.4 Q3TUN0 Q62159 RHOC_MOUSE uc290ijj.1 uc290ijj.2 Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. Interacts with RTKN (PubMed:8662891). Interacts with AKAP13. Interacts with DIAPH1 (By similarity). Interacts with PKN2 (PubMed:20974804). Interacts with ROCK1 and ROCK2. Interacts with ARHGDIA. Interacts with RIPOR1 (By similarity). Cell membrane ; Lipid-anchor ; Cytoplasmic side Cleavage furrow Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Up-regulated in silica-treated macrophages. Belongs to the small GTPase superfamily. Rho family. nucleotide binding mitotic cytokinesis GTPase activity protein binding GTP binding nucleus cytoplasm cytosol plasma membrane cell cortex actin filament organization small GTPase mediated signal transduction Rho protein signal transduction regulation of cell shape membrane cell migration protein kinase binding regulation of cell migration positive regulation of cell migration establishment or maintenance of actin cytoskeleton polarity cell division site cleavage furrow stereocilium positive regulation of protein homooligomerization regulation of actin cytoskeleton organization intracellular membrane-bounded organelle apical junction assembly wound healing, spreading of cells actin filament bundle assembly positive regulation of stress fiber assembly positive regulation of lipase activity skeletal muscle satellite cell migration uc290ijj.1 uc290ijj.2 
ENSMUST00000196822.2 Gm42481 ENSMUST00000196822.2 Gm42481 (from geneSymbol) ENSMUST00000196822.1 uc290vqi.1 uc290vqi.2 uc290vqi.1 uc290vqi.2 
ENSMUST00000196828.3 Gm23377 ENSMUST00000196828.3 Gm23377 (from geneSymbol) ENSMUST00000196828.1 ENSMUST00000196828.2 uc292lpq.1 uc292lpq.2 uc292lpq.1 uc292lpq.2 
ENSMUST00000196833.3 Mir6384 ENSMUST00000196833.3 microRNA 6384 (from RefSeq NR_105805.1) ENSMUST00000196833.1 ENSMUST00000196833.2 NR_105805 uc033jpt.1 uc033jpt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jpt.1 uc033jpt.2 
ENSMUST00000196835.2 Gm43237 ENSMUST00000196835.2 Gm43237 (from geneSymbol) AK156570 ENSMUST00000196835.1 uc290vsa.1 uc290vsa.2 uc290vsa.1 uc290vsa.2 
ENSMUST00000196839.5 Igkv12-98 ENSMUST00000196839.5 Igkv12-98 (from geneSymbol) A0A0G2JGF9 A0A0G2JGF9_MOUSE ENSMUST00000196839.1 ENSMUST00000196839.2 ENSMUST00000196839.3 ENSMUST00000196839.4 Igkv12-98 uc291fio.1 uc291fio.2 immunoglobulin production extracellular space immune response uc291fio.1 uc291fio.2 
ENSMUST00000196843.5 Ubap2l ENSMUST00000196843.5 ubiquitin-associated protein 2-like, transcript variant 9 (from RefSeq NM_001357307.1) ENSMUST00000196843.1 ENSMUST00000196843.2 ENSMUST00000196843.3 ENSMUST00000196843.4 NM_001357307 Q80X50 Q8BIT6 Q8BIW4 Q8BJ01 Q8CIG7 Q8K102 Q9CRT6 UBP2L_MOUSE Ubap2l uc008qao.1 uc008qao.2 uc008qao.3 uc008qao.4 Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (By similarity). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT- HSCs) (PubMed:25185265). Required for efficient formation of stress granules (By similarity). Interacts with BMI1. Part of a complex consisting of UBAP2L, BMI1 and RNF2. Interacts with G3BP1 (via NTF2 domain); promoting stress granule formation. Nucleus Chromosome Cytoplasm Cytoplasm, Stress granule Note=Associates with nuclear chromatin. Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q80X50-1; Sequence=Displayed; Name=2; IsoId=Q80X50-2; Sequence=VSP_019418, VSP_019421; Name=3; IsoId=Q80X50-3; Sequence=VSP_019419, VSP_019422; Name=4; IsoId=Q80X50-4; Sequence=VSP_019423; Name=5; IsoId=Q80X50-5; Sequence=VSP_019420; Sequence=BAC37777.1; Type=Frameshift; Evidence=; molecular_function Ada2/Gcn5/Ada3 transcription activator complex cytoplasm binding of sperm to zona pellucida PcG protein complex hematopoietic stem cell homeostasis uc008qao.1 uc008qao.2 uc008qao.3 uc008qao.4 
ENSMUST00000196847.2 Gm43813 ENSMUST00000196847.2 Gm43813 (from geneSymbol) ENSMUST00000196847.1 uc290zpm.1 uc290zpm.2 uc290zpm.1 uc290zpm.2 
ENSMUST00000196851.2 Gm43566 ENSMUST00000196851.2 Gm43566 (from geneSymbol) ENSMUST00000196851.1 LF194859 uc290tog.1 uc290tog.2 uc290tog.1 uc290tog.2 
ENSMUST00000196856.2 Gm42993 ENSMUST00000196856.2 Gm42993 (from geneSymbol) AK048448 ENSMUST00000196856.1 uc291ahs.1 uc291ahs.2 uc291ahs.1 uc291ahs.2 
ENSMUST00000196861.2 Hsd3b4 ENSMUST00000196861.2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4, transcript variant 2 (from RefSeq NM_008294.2) 3BHS4_MOUSE ENSMUST00000196861.1 Hsd3b4 NM_008294 Q61767 uc008qpx.1 uc008qpx.2 uc008qpx.3 uc008qpx.4 uc008qpx.5 uc008qpx.6 Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase. Reaction=a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH; Xref=Rhea:RHEA:34787, ChEBI:CHEBI:15378, ChEBI:CHEBI:36836, ChEBI:CHEBI:47788, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.270; Evidence=; Reaction=5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta- hydroxy-5alpha-androstan-3-one + H(+) + NADPH; Xref=Rhea:RHEA:16297, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:18329, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.210; Evidence=; Kinetic parameters: KM=2.2 uM for dihydrotestosterone ; Steroid metabolism. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Kidney (at protein level); found only in the cortex, appears to be associated with the proximal tubules; and a minor expression in testis. Expression between 15-20 days post-implantation occurs only in the kidney of the male fetus and not in the female, whereas a similar expression is found in adult male and female kidneys. Belongs to the 3-beta-HSD family. 3-keto sterol reductase activity 3-beta-hydroxy-delta5-steroid dehydrogenase activity steroid binding mitochondrion mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process steroid metabolic process C21-steroid hormone metabolic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor hippocampus development mitochondrial membrane response to stilbenoid intracellular membrane-bounded organelle 5alpha-androstane-3beta,17beta-diol dehydrogenase activity response to corticosterone oxidation-reduction process uc008qpx.1 uc008qpx.2 uc008qpx.3 uc008qpx.4 uc008qpx.5 uc008qpx.6 
ENSMUST00000196863.2 Igkv19-93 ENSMUST00000196863.2 Igkv19-93 (from geneSymbol) A0A0G2JFZ3 A0A0G2JFZ3_MOUSE ENSMUST00000196863.1 Igkv19-93 S78347 uc291fiz.1 uc291fiz.2 immunoglobulin production extracellular space immune response uc291fiz.1 uc291fiz.2 
ENSMUST00000196866.2 Gm42626 ENSMUST00000196866.2 Gm42626 (from geneSymbol) AK142671 ENSMUST00000196866.1 uc291aih.1 uc291aih.2 uc291aih.1 uc291aih.2 
ENSMUST00000196875.2 Gm42704 ENSMUST00000196875.2 Gm42704 (from geneSymbol) AK034713 ENSMUST00000196875.1 uc290kgi.1 uc290kgi.2 uc290kgi.1 uc290kgi.2 
ENSMUST00000196877.3 Gm9831 ENSMUST00000196877.3 predicted gene 9831, transcript variant 2 (from RefSeq NR_165825.1) ENSMUST00000196877.1 ENSMUST00000196877.2 NR_165825 uc290fis.1 uc290fis.2 uc290fis.3 uc290fis.1 uc290fis.2 uc290fis.3 
ENSMUST00000196893.2 Gm20755 ENSMUST00000196893.2 predicted gene, 20755 (from RefSeq NR_040559.1) ENSMUST00000196893.1 NR_040559 uc029uln.1 uc029uln.2 uc029uln.1 uc029uln.2 
ENSMUST00000196896.2 Gm43387 ENSMUST00000196896.2 Gm43387 (from geneSymbol) AK043928 ENSMUST00000196896.1 uc290igu.1 uc290igu.2 uc290igu.1 uc290igu.2 
ENSMUST00000196899.5 4930432M17Rik ENSMUST00000196899.5 RIKEN cDNA 4930432M17 gene (from RefSeq NR_177942.1) ENSMUST00000196899.1 ENSMUST00000196899.2 ENSMUST00000196899.3 ENSMUST00000196899.4 NR_177942 uc008red.1 uc008red.2 uc008red.3 uc008red.1 uc008red.2 uc008red.3 
ENSMUST00000196901.2 Gm43211 ENSMUST00000196901.2 Gm43211 (from geneSymbol) AK044138 ENSMUST00000196901.1 uc290jrr.1 uc290jrr.2 uc290jrr.1 uc290jrr.2 
ENSMUST00000196910.2 Cdk2ap1 ENSMUST00000196910.2 Nucleus (from UniProt F2Z4B3) BC147052 Cdk2ap1 ENSMUST00000196910.1 F2Z4B3 F2Z4B3_MOUSE uc290zun.1 uc290zun.2 Nucleus Belongs to the CDK2AP family. uc290zun.1 uc290zun.2 
ENSMUST00000196920.2 Gm42934 ENSMUST00000196920.2 Gm42934 (from geneSymbol) ENSMUST00000196920.1 uc290xou.1 uc290xou.2 uc290xou.1 uc290xou.2 
ENSMUST00000196922.2 Gm43592 ENSMUST00000196922.2 Gm43592 (from geneSymbol) ENSMUST00000196922.1 uc290xwx.1 uc290xwx.2 uc290xwx.1 uc290xwx.2 
ENSMUST00000196925.2 Gm43759 ENSMUST00000196925.2 Gm43759 (from geneSymbol) AK016815 ENSMUST00000196925.1 uc290yjn.1 uc290yjn.2 uc290yjn.1 uc290yjn.2 
ENSMUST00000196937.2 Gm42972 ENSMUST00000196937.2 Gm42972 (from geneSymbol) AK162831 ENSMUST00000196937.1 uc290jna.1 uc290jna.2 uc290jna.1 uc290jna.2 
ENSMUST00000196939.2 Trav2 ENSMUST00000196939.2 Trav2 (from geneSymbol) ENSMUST00000196939.1 Q5R1I9 Q5R1I9_MOUSE TRAV2 Trav2 X03760 uc007tpo.1 uc007tpo.2 uc007tpo.3 uc007tpo.4 uc007tpo.1 uc007tpo.2 uc007tpo.3 uc007tpo.4 
ENSMUST00000196940.2 Igkv3-10 ENSMUST00000196940.2 Igkv3-10 (from geneSymbol) A0A0G2JGN0 A0A0G2JGN0_MOUSE AY081862 ENSMUST00000196940.1 Igkv3-10 uc291fot.1 uc291fot.2 immunoglobulin production extracellular space immune response uc291fot.1 uc291fot.2 
ENSMUST00000196941.2 Trav13n-2 ENSMUST00000196941.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A0G2JF93) A0A0G2JF93 A0A0G2JF93_MOUSE ENSMUST00000196941.1 Trav13d-2 Trav13n-2 U07879 uc288tzg.1 uc288tzg.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc288tzg.1 uc288tzg.2 
ENSMUST00000196944.2 Gm43147 ENSMUST00000196944.2 Gm43147 (from geneSymbol) ENSMUST00000196944.1 uc290xid.1 uc290xid.2 uc290xid.1 uc290xid.2 
ENSMUST00000196947.3 4930520M14Rik ENSMUST00000196947.3 4930520M14Rik (from geneSymbol) AK019689 ENSMUST00000196947.1 ENSMUST00000196947.2 uc291bet.1 uc291bet.2 uc291bet.3 uc291bet.1 uc291bet.2 uc291bet.3 
ENSMUST00000196948.2 Gm43019 ENSMUST00000196948.2 Gm43019 (from geneSymbol) ENSMUST00000196948.1 uc291aia.1 uc291aia.2 uc291aia.1 uc291aia.2 
ENSMUST00000196949.2 Gm43729 ENSMUST00000196949.2 Gm43729 (from geneSymbol) ENSMUST00000196949.1 uc290jns.1 uc290jns.2 uc290jns.1 uc290jns.2 
ENSMUST00000196950.5 5730480H06Rik ENSMUST00000196950.5 5730480H06Rik (from geneSymbol) AK032498 ENSMUST00000196950.1 ENSMUST00000196950.2 ENSMUST00000196950.3 ENSMUST00000196950.4 PACRL_MOUSE Pacrgl Q9D3X5 uc008xjs.1 uc008xjs.2 uc008xjs.3 molecular_function cellular_component biological_process uc008xjs.1 uc008xjs.2 uc008xjs.3 
ENSMUST00000196955.2 Gm42659 ENSMUST00000196955.2 Gm42659 (from geneSymbol) ENSMUST00000196955.1 uc290ijw.1 uc290ijw.2 uc290ijw.1 uc290ijw.2 
ENSMUST00000196957.2 Gm43119 ENSMUST00000196957.2 Gm43119 (from geneSymbol) AK077999 ENSMUST00000196957.1 uc290yhx.1 uc290yhx.2 uc290yhx.1 uc290yhx.2 
ENSMUST00000196959.2 Igkv8-34 ENSMUST00000196959.2 Igkv8-34 (from geneSymbol) A0A0G2JDU0 A0A0G2JDU0_MOUSE ENSMUST00000196959.1 Igkv8-34 uc291fmw.1 uc291fmw.2 immunoglobulin production extracellular space immune response uc291fmw.1 uc291fmw.2 
ENSMUST00000196971.2 1810013D15Rik ENSMUST00000196971.2 1810013D15Rik (from geneSymbol) AK007475 ENSMUST00000196971.1 uc290kvz.1 uc290kvz.2 uc290kvz.1 uc290kvz.2 
ENSMUST00000196977.2 Traj57 ENSMUST00000196977.2 Traj57 (from geneSymbol) A0A0G2JH10 A0A0G2JH10_MOUSE ENSMUST00000196977.1 Traj57 U89742 uc288uci.1 uc288uci.2 uc288uci.1 uc288uci.2 
ENSMUST00000196979.5 Tm4sf1 ENSMUST00000196979.5 transmembrane 4 superfamily member 1, transcript variant 1 (from RefSeq NM_008536.5) ENSMUST00000196979.1 ENSMUST00000196979.2 ENSMUST00000196979.3 ENSMUST00000196979.4 M3s1 NM_008536 Q3TP49 Q64302 T4S1_MOUSE uc008pgy.1 uc008pgy.2 uc008pgy.3 Present in high molecular weight complexes in tumor cells. Interacts with SDCBP2 (By similarity). Membrane; Multi-pass membrane protein. Note=Colocalizes with SDCBP2 in the apical region of the cell. Highly expressed in skin and lung. Moderately expressed in lymph nodes and kidneys. Also present in thymic stroma and fibroblasts. Belongs to the L6 tetraspanin family. blastocyst formation integral component of plasma membrane membrane integral component of membrane uc008pgy.1 uc008pgy.2 uc008pgy.3 
ENSMUST00000196982.2 Gm42909 ENSMUST00000196982.2 Gm42909 (from geneSymbol) AK141480 ENSMUST00000196982.1 uc290tes.1 uc290tes.2 uc290tes.1 uc290tes.2 
ENSMUST00000196989.2 Gm42876 ENSMUST00000196989.2 Gm42876 (from geneSymbol) AK033102 ENSMUST00000196989.1 uc290juj.1 uc290juj.2 uc290juj.1 uc290juj.2 
ENSMUST00000196991.2 Ighv1-82 ENSMUST00000196991.2 Ighv1-82 (from geneSymbol) A0A0G2JEU7 A0A0G2JEU7_MOUSE AF045497 ENSMUST00000196991.1 Ighv1-82 uc288kdj.1 uc288kdj.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kdj.1 uc288kdj.2 
ENSMUST00000196993.3 BC037156 ENSMUST00000196993.3 cDNA sequence BC037156 (from RefSeq NM_001305431.1) BC037156 ENSMUST00000196993.1 ENSMUST00000196993.2 FDC-SP H9CWD5 H9CWD5_MOUSE NM_001305431 uc008xzf.1 uc008xzf.2 uc008xzf.3 uc008xzf.4 uc008xzf.1 uc008xzf.2 uc008xzf.3 uc008xzf.4 
ENSMUST00000196994.2 Gm43244 ENSMUST00000196994.2 Gm43244 (from geneSymbol) AK048509 ENSMUST00000196994.1 uc290ics.1 uc290ics.2 uc290ics.1 uc290ics.2 
ENSMUST00000196996.2 Gm42445 ENSMUST00000196996.2 Gm42445 (from geneSymbol) ENSMUST00000196996.1 uc290tgd.1 uc290tgd.2 uc290tgd.1 uc290tgd.2 
ENSMUST00000196999.5 Rpe65 ENSMUST00000196999.5 retinal pigment epithelium 65 (from RefSeq NM_029987.2) A1L3D1 E9QNS6 ENSMUST00000196999.1 ENSMUST00000196999.2 ENSMUST00000196999.3 ENSMUST00000196999.4 H9KUX9 NM_029987 Q8VHP2 Q91ZQ5 RPE65_MOUSE uc008rwb.1 uc008rwb.2 uc008rwb.3 Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:15765048, PubMed:9843205, PubMed:23407971, PubMed:28500718). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17251447). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity). Reaction=an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+); Xref=Rhea:RHEA:31771, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16302, ChEBI:CHEBI:28868, ChEBI:CHEBI:63410; EC=3.1.1.64; Evidence=; Reaction=lutein = (3R,3'S)-zeaxanthin; Xref=Rhea:RHEA:12729, ChEBI:CHEBI:28838, ChEBI:CHEBI:138919; EC=5.3.3.22; Evidence=; Reaction=all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate; Xref=Rhea:RHEA:31775, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16302, ChEBI:CHEBI:17616; EC=3.1.1.64; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Interacts with MYO7A; this mediates light-dependent intracellular transport of RPE65. Q91ZQ5; P97479: Myo7a; NbExp=3; IntAct=EBI-11682496, EBI-1149557; Cytoplasm Cell membrane ; Lipid-anchor Microsome membrane Note=Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated. Undergoes light-dependent intracellular transport to become more concentrated in the central region of the retina pigment epithelium cells (By similarity). Retinal pigment epithelium specific. Palmitoylation by LRAT regulates ligand binding specificity; the palmitoylated form (membrane form) specifically binds all-trans- retinyl-palmitate, while the soluble unpalmitoylated form binds all- trans-retinol (vitamin A). Note=Defects in Rpe65 are the cause of light damage susceptibility (LDS) of the retina. Mice exhibit changes in retinal physiology and biochemistry. Outer segment disks of rod photoreceptors are disorganized, rod function is abolished although cone function remains. Mice lack rhodopsin, but not opsin apoprotein. Furthermore, all-trans- retinyl esters over-accumulate in the retinal pigment epithelium, whereas 11-cis-retinyl esters are absent. Belongs to the carotenoid oxygenase family. retinoid metabolic process phosphatidylserine binding retina homeostasis neural retina development retinal isomerase activity protein binding cytoplasm endoplasmic reticulum endoplasmic reticulum membrane plasma membrane regulation of rhodopsin gene expression visual perception circadian rhythm insulin receptor signaling pathway response to light stimulus membrane oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen hydrolase activity isomerase activity organelle membrane phosphatidylcholine binding retinol metabolic process retinal metabolic process camera-type eye development intracellular membrane-bounded organelle cell body metal ion binding retinol isomerase activity response to stimulus detection of light stimulus involved in visual perception all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity oxidation-reduction process retina development in camera-type eye retina morphogenesis in camera-type eye cellular response to electrical stimulus cardiolipin binding zeaxanthin biosynthetic process uc008rwb.1 uc008rwb.2 uc008rwb.3 
ENSMUST00000197000.2 4930512P04Rik ENSMUST00000197000.2 4930512P04Rik (from geneSymbol) AK019678 ENSMUST00000197000.1 uc290jal.1 uc290jal.2 uc290jal.1 uc290jal.2 
ENSMUST00000197001.2 Gm43181 ENSMUST00000197001.2 Gm43181 (from geneSymbol) ENSMUST00000197001.1 LF194939 uc290veb.1 uc290veb.2 uc290veb.1 uc290veb.2 
ENSMUST00000197004.2 Gm43856 ENSMUST00000197004.2 Gm43856 (from geneSymbol) ENSMUST00000197004.1 uc290xrq.1 uc290xrq.2 uc290xrq.1 uc290xrq.2 
ENSMUST00000197007.2 Trav12d-2 ENSMUST00000197007.2 Trav12d-2 (from geneSymbol) A0A0G2JF09 A0A0G2JF09_MOUSE ENSMUST00000197007.1 M15063 Trav12d-2 Trav12n-2 uc288txj.1 uc288txj.2 immunoglobulin production extracellular space immune response uc288txj.1 uc288txj.2 
ENSMUST00000197014.2 Gm43668 ENSMUST00000197014.2 Gm43668 (from geneSymbol) ENSMUST00000197014.1 LF193886 uc012coq.1 uc012coq.2 uc012coq.3 uc012coq.1 uc012coq.2 uc012coq.3 
ENSMUST00000197016.5 D5Ertd615e ENSMUST00000197016.5 DNA segment, Chr 5, ERATO Doi 615, expressed (from RefSeq NR_131933.1) ENSMUST00000197016.1 ENSMUST00000197016.2 ENSMUST00000197016.3 ENSMUST00000197016.4 NR_131933 uc057buf.1 uc057buf.2 uc057buf.3 uc057buf.1 uc057buf.2 uc057buf.3 
ENSMUST00000197020.2 Gm43161 ENSMUST00000197020.2 Gm43161 (from geneSymbol) ENSMUST00000197020.1 uc290twn.1 uc290twn.2 uc290twn.1 uc290twn.2 
ENSMUST00000197021.2 Ankrd17 ENSMUST00000197021.2 ankyrin repeat domain 17, transcript variant 3 (from RefSeq NM_001401341.1) A0A0G2JDZ9 A0A0G2JDZ9_MOUSE Ankrd17 ENSMUST00000197021.1 NM_001401341 uc290wyc.1 uc290wyc.2 nucleic acid binding RNA binding uc290wyc.1 uc290wyc.2 
ENSMUST00000197023.3 Mir7661 ENSMUST00000197023.3 microRNA 7661 (from RefSeq NR_106121.1) ENSMUST00000197023.1 ENSMUST00000197023.2 NR_106121 uc033itv.1 uc033itv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033itv.1 uc033itv.2 
ENSMUST00000197026.3 Mir7021 ENSMUST00000197026.3 microRNA 7021 (from RefSeq NR_105988.1) ENSMUST00000197026.1 ENSMUST00000197026.2 NR_105988 uc033igk.1 uc033igk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033igk.1 uc033igk.2 
ENSMUST00000197034.2 Gm42899 ENSMUST00000197034.2 Gm42899 (from geneSymbol) ENSMUST00000197034.1 uc290ffd.1 uc290ffd.2 uc290ffd.1 uc290ffd.2 
ENSMUST00000197043.2 Gm42992 ENSMUST00000197043.2 Gm42992 (from geneSymbol) AK140583 ENSMUST00000197043.1 uc008zux.1 uc008zux.2 uc008zux.3 uc008zux.1 uc008zux.2 uc008zux.3 
ENSMUST00000197046.2 Iglc4 ENSMUST00000197046.2 Iglc4 (from geneSymbol) A0A0G2JEK5 A0A0G2JEK5_MOUSE ENSMUST00000197046.1 Iglc4 uc289dgs.1 uc289dgs.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc289dgs.1 uc289dgs.2 
ENSMUST00000197047.2 Gm42995 ENSMUST00000197047.2 Gm42995 (from geneSymbol) ENSMUST00000197047.1 uc291ahx.1 uc291ahx.2 uc291ahx.1 uc291ahx.2 
ENSMUST00000197051.2 Gm43679 ENSMUST00000197051.2 Gm43679 (from geneSymbol) AB351918 ENSMUST00000197051.1 uc290sua.1 uc290sua.2 uc290sua.1 uc290sua.2 
ENSMUST00000197053.2 Gm42998 ENSMUST00000197053.2 Gm42998 (from geneSymbol) ENSMUST00000197053.1 LF194211 uc290jry.1 uc290jry.2 uc290jry.1 uc290jry.2 
ENSMUST00000197054.2 Gm42949 ENSMUST00000197054.2 Gm42949 (from geneSymbol) AK139135 ENSMUST00000197054.1 uc290knh.1 uc290knh.2 uc290knh.1 uc290knh.2 
ENSMUST00000197060.2 Gm42711 ENSMUST00000197060.2 Gm42711 (from geneSymbol) AK076377 ENSMUST00000197060.1 uc290vcx.1 uc290vcx.2 uc290vcx.1 uc290vcx.2 
ENSMUST00000197061.2 Gm42639 ENSMUST00000197061.2 Gm42639 (from geneSymbol) ENSMUST00000197061.1 uc290vqp.1 uc290vqp.2 uc290vqp.1 uc290vqp.2 
ENSMUST00000197062.3 Mir7229 ENSMUST00000197062.3 microRNA 7229 (from RefSeq NR_106088.1) ENSMUST00000197062.1 ENSMUST00000197062.2 NR_106088 uc008yup.1 uc008yup.2 uc008yup.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc008yup.1 uc008yup.2 uc008yup.3 
ENSMUST00000197067.2 Gm43022 ENSMUST00000197067.2 Gm43022 (from geneSymbol) AK053059 ENSMUST00000197067.1 uc290vdn.1 uc290vdn.2 uc290vdn.1 uc290vdn.2 
ENSMUST00000197071.2 Gm42837 ENSMUST00000197071.2 Gm42837 (from geneSymbol) ENSMUST00000197071.1 uc290jrs.1 uc290jrs.2 uc290jrs.1 uc290jrs.2 
ENSMUST00000197075.2 Gm42783 ENSMUST00000197075.2 Gm42783 (from geneSymbol) AK046157 ENSMUST00000197075.1 uc290hvt.1 uc290hvt.2 uc290hvt.1 uc290hvt.2 
ENSMUST00000197076.3 Mir677 ENSMUST00000197076.3 microRNA 677 (from RefSeq NR_030442.2) ENSMUST00000197076.1 ENSMUST00000197076.2 NR_030442 uc011xpy.1 uc011xpy.2 uc011xpy.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609678.1 [ECO:0000345] ##Evidence-Data-END## uc011xpy.1 uc011xpy.2 uc011xpy.3 
ENSMUST00000197083.2 Gm42780 ENSMUST00000197083.2 Gm42780 (from geneSymbol) ENSMUST00000197083.1 uc290yhl.1 uc290yhl.2 uc290yhl.1 uc290yhl.2 
ENSMUST00000197084.2 Gm43511 ENSMUST00000197084.2 Gm43511 (from geneSymbol) AK139193 ENSMUST00000197084.1 uc290xnp.1 uc290xnp.2 uc290xnp.1 uc290xnp.2 
ENSMUST00000197086.2 Gm42679 ENSMUST00000197086.2 Gm42679 (from geneSymbol) AK087613 ENSMUST00000197086.1 uc290idh.1 uc290idh.2 uc290idh.1 uc290idh.2 
ENSMUST00000197090.2 Gm43577 ENSMUST00000197090.2 Gm43577 (from geneSymbol) AB344912 ENSMUST00000197090.1 uc290svw.1 uc290svw.2 uc290svw.1 uc290svw.2 
ENSMUST00000197097.2 Gm43834 ENSMUST00000197097.2 Gm43834 (from geneSymbol) ENSMUST00000197097.1 uc290dzg.1 uc290dzg.2 uc290dzg.1 uc290dzg.2 
ENSMUST00000197100.2 Gm43557 ENSMUST00000197100.2 Gm43557 (from geneSymbol) ENSMUST00000197100.1 uc291bjf.1 uc291bjf.2 uc291bjf.1 uc291bjf.2 
ENSMUST00000197105.3 Mir703 ENSMUST00000197105.3 microRNA 703 (from RefSeq NR_030484.1) ENSMUST00000197105.1 ENSMUST00000197105.2 NR_030484 uc012dzn.1 uc012dzn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609703.1 [ECO:0000345] ##Evidence-Data-END## uc012dzn.1 uc012dzn.2 
ENSMUST00000197106.3 Mir3969 ENSMUST00000197106.3 microRNA 3969 (from RefSeq NR_039550.1) ENSMUST00000197106.1 ENSMUST00000197106.2 NR_039550 uc029viv.1 uc029viv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611362.1 [ECO:0000345] ##Evidence-Data-END## uc029viv.1 uc029viv.2 
ENSMUST00000197113.2 Trgj2 ENSMUST00000197113.2 Trgj2 (from geneSymbol) A0A0G2JGW7 A0A0G2JGW7_MOUSE ENSMUST00000197113.1 Trgj1 Trgj2 uc288lbz.1 uc288lbz.2 uc288lbz.1 uc288lbz.2 
ENSMUST00000197115.2 Gm42987 ENSMUST00000197115.2 Gm42987 (from geneSymbol) AK166914 ENSMUST00000197115.1 uc290xoc.1 uc290xoc.2 uc290xoc.1 uc290xoc.2 
ENSMUST00000197119.2 Gm43627 ENSMUST00000197119.2 Gm43627 (from geneSymbol) AK078020 ENSMUST00000197119.1 uc290vun.1 uc290vun.2 uc290vun.1 uc290vun.2 
ENSMUST00000197120.2 Gm42566 ENSMUST00000197120.2 Gm42566 (from geneSymbol) AB351189 ENSMUST00000197120.1 uc290vtq.1 uc290vtq.2 uc290vtq.1 uc290vtq.2 
ENSMUST00000197122.2 Gm42448 ENSMUST00000197122.2 Gm42448 (from geneSymbol) ENSMUST00000197122.1 uc290tgb.1 uc290tgb.2 uc290tgb.1 uc290tgb.2 
ENSMUST00000197128.2 Trav7d-5 ENSMUST00000197128.2 Trav7d-5 (from geneSymbol) A0A075B604 A0A075B604_MOUSE ENSMUST00000197128.1 Trav7d-5 Trav7n-5 uc288tww.1 uc288tww.2 uc288tww.1 uc288tww.2 
ENSMUST00000197130.5 Trdv2-1 ENSMUST00000197130.5 Trdv2-1 (from geneSymbol) A0A0G2JGB9 A0A0G2JGB9_MOUSE ENSMUST00000197130.1 ENSMUST00000197130.2 ENSMUST00000197130.3 ENSMUST00000197130.4 Trdv2-1 uc288ubo.1 uc288ubo.2 immunoglobulin production extracellular space immune response uc288ubo.1 uc288ubo.2 
ENSMUST00000197139.2 Gm43548 ENSMUST00000197139.2 Gm43548 (from geneSymbol) AK082122 ENSMUST00000197139.1 uc290fja.1 uc290fja.2 uc290fja.1 uc290fja.2 
ENSMUST00000197163.2 Gm42678 ENSMUST00000197163.2 Gm42678 (from geneSymbol) AK146850 ENSMUST00000197163.1 uc290idi.1 uc290idi.2 uc290idi.1 uc290idi.2 
ENSMUST00000197165.2 Gm42721 ENSMUST00000197165.2 Gm42721 (from geneSymbol) ENSMUST00000197165.1 uc290imb.1 uc290imb.2 uc290imb.1 uc290imb.2 
ENSMUST00000197171.2 C130083M11Rik ENSMUST00000197171.2 RIKEN cDNA C130083M11 gene (from RefSeq NR_040717.1) ENSMUST00000197171.1 NR_040717 uc029vhj.1 uc029vhj.2 uc029vhj.3 uc029vhj.1 uc029vhj.2 uc029vhj.3 
ENSMUST00000197174.2 Gm42636 ENSMUST00000197174.2 Gm42636 (from geneSymbol) ENSMUST00000197174.1 LF195294 uc291bsl.1 uc291bsl.2 uc291bsl.1 uc291bsl.2 
ENSMUST00000197178.3 Gm43020 ENSMUST00000197178.3 Gm43020 (from geneSymbol) ENSMUST00000197178.1 ENSMUST00000197178.2 uc290vdj.1 uc290vdj.2 uc290vdj.3 uc290vdj.1 uc290vdj.2 uc290vdj.3 
ENSMUST00000197180.6 Cfap47 ENSMUST00000197180.6 cilia and flagella associated protein 47 (from RefSeq NM_001368718.2) A0A0G2JEB6 CFA47_MOUSE Cfap47 ENSMUST00000197180.1 ENSMUST00000197180.2 ENSMUST00000197180.3 ENSMUST00000197180.4 ENSMUST00000197180.5 NM_001368718 uc292pfn.1 uc292pfn.2 uc292pfn.3 Plays a role in flagellar formation and sperm motility. Interacts with CFAP65. Cytoplasm, cytoskeleton, flagellum basal body Highly expressed in spermatzoa (at protein level). molecular_function cellular_component biological_process uc292pfn.1 uc292pfn.2 uc292pfn.3 
ENSMUST00000197184.2 Gm42900 ENSMUST00000197184.2 Gm42900 (from geneSymbol) AK040244 ENSMUST00000197184.1 uc290xvg.1 uc290xvg.2 uc290xvg.1 uc290xvg.2 
ENSMUST00000197188.5 Ankle2 ENSMUST00000197188.5 ankyrin repeat and LEM domain containing 2, transcript variant 1 (from RefSeq NM_001253814.1) ANKL2_MOUSE D5Ertd585e ENSMUST00000197188.1 ENSMUST00000197188.2 ENSMUST00000197188.3 ENSMUST00000197188.4 Kiaa0692 Lem4 NM_001253814 Q3UQF6 Q3UY52 Q3V1X7 Q6P1H6 Q6ZQ67 Q8BRM7 Q9CTK6 uc008yqg.1 uc008yqg.2 uc008yqg.3 uc008yqg.4 Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development. Interacts with BAF/BANF1. Interacts with protein phosphatase 2A (PP2A) components PPP2C (PPP2CA or PPP2CB) and PPP2R1A (By similarity). Endoplasmic reticulum membrane ; Single-pass type III membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6P1H6-1; Sequence=Displayed; Name=2; IsoId=Q6P1H6-2; Sequence=VSP_023576; Name=3; IsoId=Q6P1H6-3; Sequence=VSP_023579; Name=4; IsoId=Q6P1H6-4; Sequence=VSP_023577, VSP_023578; Belongs to the ANKLE2 family. endoplasmic reticulum endoplasmic reticulum membrane cell cycle mitotic nuclear envelope reassembly central nervous system development membrane integral component of membrane integral component of endoplasmic reticulum membrane positive regulation of protein dephosphorylation negative regulation of phosphorylation negative regulation of apoptotic process cell division protein phosphatase 2A binding uc008yqg.1 uc008yqg.2 uc008yqg.3 uc008yqg.4 
ENSMUST00000197195.3 Gm42912 ENSMUST00000197195.3 Gm42912 (from geneSymbol) AK042933 ENSMUST00000197195.1 ENSMUST00000197195.2 uc008yai.1 uc008yai.2 uc008yai.3 uc008yai.1 uc008yai.2 uc008yai.3 
ENSMUST00000197198.2 Gm42836 ENSMUST00000197198.2 Gm42836 (from geneSymbol) ENSMUST00000197198.1 uc290jgx.1 uc290jgx.2 uc290jgx.1 uc290jgx.2 
ENSMUST00000197199.2 Gm42658 ENSMUST00000197199.2 Gm42658 (from geneSymbol) ENSMUST00000197199.1 uc290iju.1 uc290iju.2 uc290iju.1 uc290iju.2 
ENSMUST00000197200.3 4921539H07Rik ENSMUST00000197200.3 4921539H07Rik (from geneSymbol) AK158543 ENSMUST00000197200.1 ENSMUST00000197200.2 uc290fle.1 uc290fle.2 uc290fle.3 uc290fle.1 uc290fle.2 uc290fle.3 
ENSMUST00000197208.2 Gm43541 ENSMUST00000197208.2 Gm43541 (from geneSymbol) ENSMUST00000197208.1 uc290zky.1 uc290zky.2 uc290zky.1 uc290zky.2 
ENSMUST00000197216.3 Tmem217rt ENSMUST00000197216.3 transmembrane 217, retrotransposed (from RefSeq NM_001374743.1) A0A1Y7VLQ2 A0A1Y7VLQ2_MOUSE ENSMUST00000197216.1 ENSMUST00000197216.2 Gm42517 NM_001374743 Tmem217rt uc290xyn.1 uc290xyn.2 membrane integral component of membrane uc290xyn.1 uc290xyn.2 
ENSMUST00000197219.2 A930028O11Rik ENSMUST00000197219.2 A930028O11Rik (from geneSymbol) ENSMUST00000197219.1 uc290flv.1 uc290flv.2 uc290flv.1 uc290flv.2 
ENSMUST00000197222.2 Gm43078 ENSMUST00000197222.2 Gm43078 (from geneSymbol) ENSMUST00000197222.1 X75261 uc290ent.1 uc290ent.2 uc290ent.1 uc290ent.2 
ENSMUST00000197233.2 Gm43071 ENSMUST00000197233.2 Gm43071 (from geneSymbol) AK037048 ENSMUST00000197233.1 uc290ink.1 uc290ink.2 uc290ink.1 uc290ink.2 
ENSMUST00000197237.2 Tex13d ENSMUST00000197237.2 Belongs to the TEX13 family. (from UniProt A0A0G2JGA3) A0A0G2JGA3 A0A0G2JGA3_MOUSE ENSMUST00000197237.1 Tex13d uc292nyg.1 uc292nyg.2 Belongs to the TEX13 family. molecular_function cellular_component biological_process metal ion binding uc292nyg.1 uc292nyg.2 
ENSMUST00000197238.5 Ccna1 ENSMUST00000197238.5 May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. (from UniProt Q61456) AK077114 CCNA1_MOUSE ENSMUST00000197238.1 ENSMUST00000197238.2 ENSMUST00000197238.3 ENSMUST00000197238.4 Q61456 Q8C5U1 uc290fhz.1 uc290fhz.2 May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. Interacts with INCA1 and KLHDC9 (By similarity). Interacts with the CDK2 and CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNE1. Nucleus Cytoplasm, cytoskeleton, spindle. Note=In oocytes at least, it associates with the spindle during metaphase. Testis and ovaries. In male germ cells just prior to or during the first, but not the second meiotic division. Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase- promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity). CCNA1 -/- males are sterile due to a block of spermatogenesis before the first meiotic division, whereas females are normal. Belongs to the cyclin family. Cyclin AB subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein kinase holoenzyme complex protein binding nucleus cytoplasm spindle cytoskeleton protein phosphorylation cell cycle multicellular organism development spermatogenesis microtubule cytoskeleton cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding cell differentiation mitotic cell cycle phase transition cell division meiotic cell cycle cyclin A1-CDK2 complex cyclin A2-CDK2 complex protein kinase activity uc290fhz.1 uc290fhz.2 
ENSMUST00000197239.2 Gm43519 ENSMUST00000197239.2 Gm43519 (from geneSymbol) ENSMUST00000197239.1 uc290tfu.1 uc290tfu.2 uc290tfu.1 uc290tfu.2 
ENSMUST00000197247.2 Gm43184 ENSMUST00000197247.2 Gm43184 (from geneSymbol) ENSMUST00000197247.1 uc290ven.1 uc290ven.2 uc290ven.1 uc290ven.2 
ENSMUST00000197249.2 Gm42591 ENSMUST00000197249.2 Gm42591 (from geneSymbol) ENSMUST00000197249.1 uc291ahh.1 uc291ahh.2 uc291ahh.1 uc291ahh.2 
ENSMUST00000197251.2 Gm43508 ENSMUST00000197251.2 Gm43508 (from geneSymbol) AK040238 ENSMUST00000197251.1 uc290vfx.1 uc290vfx.2 uc290vfx.1 uc290vfx.2 
ENSMUST00000197252.2 Gm43316 ENSMUST00000197252.2 Gm43316 (from geneSymbol) AK083109 ENSMUST00000197252.1 uc290vkg.1 uc290vkg.2 uc290vkg.1 uc290vkg.2 
ENSMUST00000197257.2 Gm43178 ENSMUST00000197257.2 Gm43178 (from geneSymbol) ENSMUST00000197257.1 LF194957 uc290vmd.1 uc290vmd.2 uc290vmd.1 uc290vmd.2 
ENSMUST00000197262.2 Gm15860 ENSMUST00000197262.2 Gm15860 (from geneSymbol) ENSMUST00000197262.1 uc290zpc.1 uc290zpc.2 uc290zpc.1 uc290zpc.2 
ENSMUST00000197263.2 Gm42437 ENSMUST00000197263.2 Gm42437 (from geneSymbol) AK135832 ENSMUST00000197263.1 uc290ewt.1 uc290ewt.2 uc290ewt.1 uc290ewt.2 
ENSMUST00000197269.2 Gm43777 ENSMUST00000197269.2 Gm43777 (from geneSymbol) ENSMUST00000197269.1 uc290zxj.1 uc290zxj.2 uc290zxj.1 uc290zxj.2 
ENSMUST00000197272.2 Igkv8-27 ENSMUST00000197272.2 Igkv8-27 (from geneSymbol) A0A0G2JF28 A0A0G2JF28_MOUSE DQ781318 ENSMUST00000197272.1 Igkv8-27 uc291fnj.1 uc291fnj.2 immunoglobulin production extracellular space immune response uc291fnj.1 uc291fnj.2 
ENSMUST00000197277.2 Gm30613 ENSMUST00000197277.2 Gm30613 (from geneSymbol) ENSMUST00000197277.1 uc290tgr.1 uc290tgr.2 uc290tgr.1 uc290tgr.2 
ENSMUST00000197283.2 Mir873b ENSMUST00000197283.2 microRNA 873b (from RefSeq NR_105849.1) ENSMUST00000197283.1 NR_105849 uc033ibc.1 uc033ibc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609956.1 [ECO:0000345] ##Evidence-Data-END## uc033ibc.1 uc033ibc.2 
ENSMUST00000197284.5 Gabra2 ENSMUST00000197284.5 gamma-aminobutyric acid type A receptor subunit alpha 2 (from RefSeq NM_008066.4) ENSMUST00000197284.1 ENSMUST00000197284.2 ENSMUST00000197284.3 ENSMUST00000197284.4 Gabra2 NM_008066 Q544G1 Q544G1_MOUSE uc008xqw.1 uc008xqw.2 uc008xqw.3 Cell membrane ; Multi-pass membrane protein Cell projection, dendrite Cytoplasmic vesicle membrane Membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub- subfamily. transmembrane signaling receptor activity GABA-A receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane ion transport chloride transport gamma-aminobutyric acid signaling pathway membrane integral component of membrane ion transmembrane transport uc008xqw.1 uc008xqw.2 uc008xqw.3 
ENSMUST00000197286.2 Gm42782 ENSMUST00000197286.2 Gm42782 (from geneSymbol) ENSMUST00000197286.1 uc290hvw.1 uc290hvw.2 uc290hvw.1 uc290hvw.2 
ENSMUST00000197287.2 Gm43426 ENSMUST00000197287.2 Gm43426 (from geneSymbol) ENSMUST00000197287.1 uc290viq.1 uc290viq.2 uc290viq.1 uc290viq.2 
ENSMUST00000197290.2 Igkv5-39 ENSMUST00000197290.2 Igkv5-39 (from geneSymbol) A0A0G2JDV4 A0A0G2JDV4_MOUSE ENSMUST00000197290.1 Igkv5-39 uc291fml.1 uc291fml.2 immunoglobulin production extracellular space immune response uc291fml.1 uc291fml.2 
ENSMUST00000197294.2 Gm43400 ENSMUST00000197294.2 Gm43400 (from geneSymbol) ENSMUST00000197294.1 uc290ksm.1 uc290ksm.2 uc290ksm.1 uc290ksm.2 
ENSMUST00000197297.2 1700015C17Rik ENSMUST00000197297.2 1700015C17Rik (from geneSymbol) AK005987 ENSMUST00000197297.1 uc290krl.1 uc290krl.2 uc290krl.1 uc290krl.2 
ENSMUST00000197305.2 4930526M16Rik ENSMUST00000197305.2 4930526M16Rik (from geneSymbol) ENSMUST00000197305.1 uc290vtn.1 uc290vtn.2 uc290vtn.1 uc290vtn.2 
ENSMUST00000197309.2 Gm42717 ENSMUST00000197309.2 Gm42717 (from geneSymbol) AK143493 ENSMUST00000197309.1 uc290hzt.1 uc290hzt.2 uc290hzt.1 uc290hzt.2 
ENSMUST00000197312.3 Gm42535 ENSMUST00000197312.3 Gm42535 (from geneSymbol) ENSMUST00000197312.1 ENSMUST00000197312.2 uc290vjf.1 uc290vjf.2 uc290vjf.1 uc290vjf.2 
ENSMUST00000197315.5 Tlr1 ENSMUST00000197315.5 toll-like receptor 1, transcript variant 2 (from RefSeq NM_001276445.1) ENSMUST00000197315.1 ENSMUST00000197315.2 ENSMUST00000197315.3 ENSMUST00000197315.4 NM_001276445 Q9EPQ1 Q9EPW5 TLR1_MOUSE uc008xmw.1 uc008xmw.2 uc008xmw.3 uc008xmw.4 Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Acts as a coreceptor for M.tuberculosis lipoproteins LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR2 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Interacts (via extracellular domain) with TLR2. TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (By similarity). Binds MYD88 (via TIR domain). Interacts with CNPY3 (PubMed:17998391). Cell membrane ingle-pass type I membrane protein Cytoplasmic vesicle, phagosome membrane ; Single-pass type I membrane protein Membrane raft Golgi apparatus Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. Belongs to the Toll-like receptor family. In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity. microglial cell activation cell activation toll-like receptor signaling pathway immune system process MyD88-dependent toll-like receptor signaling pathway transmembrane signaling receptor activity Golgi apparatus plasma membrane integral component of plasma membrane defense response inflammatory response signal transduction activation of NF-kappaB-inducing kinase activity membrane integral component of membrane phagocytic vesicle membrane cytoplasmic vesicle response to bacterial lipoprotein toll-like receptor 1 signaling pathway positive regulation of toll-like receptor 2 signaling pathway Toll-like receptor 1-Toll-like receptor 2 protein complex Toll-like receptor 2 binding macrophage activation detection of triacyl bacterial lipopeptide triacyl lipopeptide binding positive regulation of tumor necrosis factor biosynthetic process identical protein binding innate immune response membrane raft phagocytic vesicle positive regulation of interleukin-6 biosynthetic process protein heterodimerization activity regulation of cytokine secretion lipopeptide binding cellular response to triacyl bacterial lipopeptide positive regulation of interleukin-8 secretion uc008xmw.1 uc008xmw.2 uc008xmw.3 uc008xmw.4 
ENSMUST00000197317.2 Gm43140 ENSMUST00000197317.2 Gm43140 (from geneSymbol) ENSMUST00000197317.1 uc290elx.1 uc290elx.2 uc290elx.1 uc290elx.2 
ENSMUST00000197326.2 4632404M16Rik ENSMUST00000197326.2 4632404M16Rik (from geneSymbol) ENSMUST00000197326.1 LF192502 uc290ict.1 uc290ict.2 uc290ict.1 uc290ict.2 
ENSMUST00000197332.3 Mir468 ENSMUST00000197332.3 microRNA 468 (from RefSeq NR_030151.1) ENSMUST00000197332.1 ENSMUST00000197332.2 NR_030151 uc012enr.1 uc012enr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609392.1 [ECO:0000345] ##Evidence-Data-END## uc012enr.1 uc012enr.2 
ENSMUST00000197337.2 Gm43650 ENSMUST00000197337.2 Gm43650 (from geneSymbol) ENSMUST00000197337.1 uc288tzq.1 uc288tzq.2 uc288tzq.1 uc288tzq.2 
ENSMUST00000197338.2 Gm42928 ENSMUST00000197338.2 Gm42928 (from geneSymbol) ENSMUST00000197338.1 uc290jee.1 uc290jee.2 uc290jee.1 uc290jee.2 
ENSMUST00000197341.2 Gm20752 ENSMUST00000197341.2 predicted gene, 20752 (from RefSeq NR_040750.1) ENSMUST00000197341.1 NR_040750 uc029upi.1 uc029upi.2 uc029upi.3 uc029upi.1 uc029upi.2 uc029upi.3 
ENSMUST00000197351.2 Gm43686 ENSMUST00000197351.2 Gm43686 (from geneSymbol) ENSMUST00000197351.1 uc290vmo.1 uc290vmo.2 uc290vmo.1 uc290vmo.2 
ENSMUST00000197355.2 Gm42955 ENSMUST00000197355.2 Gm42955 (from geneSymbol) ENSMUST00000197355.1 uc290zzw.1 uc290zzw.2 uc290zzw.1 uc290zzw.2 
ENSMUST00000197360.2 Gm42937 ENSMUST00000197360.2 Gm42937 (from geneSymbol) AK078983 ENSMUST00000197360.1 uc290icf.1 uc290icf.2 uc290icf.1 uc290icf.2 
ENSMUST00000197362.2 Gm42634 ENSMUST00000197362.2 Gm42634 (from geneSymbol) AK198190 ENSMUST00000197362.1 uc290vqc.1 uc290vqc.2 uc290vqc.1 uc290vqc.2 
ENSMUST00000197363.2 Gm42497 ENSMUST00000197363.2 Gm42497 (from geneSymbol) ENSMUST00000197363.1 uc291aav.1 uc291aav.2 uc291aav.1 uc291aav.2 
ENSMUST00000197371.2 Igkv6-29 ENSMUST00000197371.2 Igkv6-29 (from geneSymbol) A0A0G2JEI6 A0A0G2JEI6_MOUSE ENSMUST00000197371.1 Igkv6-29 uc291fne.1 uc291fne.2 immunoglobulin production extracellular space immune response uc291fne.1 uc291fne.2 
ENSMUST00000197378.2 Gm43260 ENSMUST00000197378.2 Gm43260 (from geneSymbol) AK050434 ENSMUST00000197378.1 uc290iij.1 uc290iij.2 uc290iij.1 uc290iij.2 
ENSMUST00000197379.2 Gm10416 ENSMUST00000197379.2 predicted pseudogene 10416 (from RefSeq NR_027964.1) ENSMUST00000197379.1 NR_027964 uc012eaw.1 uc012eaw.2 uc012eaw.3 uc012eaw.1 uc012eaw.2 uc012eaw.3 
ENSMUST00000197386.3 Gm29811 ENSMUST00000197386.3 predicted gene, 29811, transcript variant 2 (from RefSeq NR_102298.1) ENSMUST00000197386.1 ENSMUST00000197386.2 NR_102298 uc008rkb.1 uc008rkb.2 uc008rkb.3 uc008rkb.1 uc008rkb.2 uc008rkb.3 
ENSMUST00000197390.2 Gm42509 ENSMUST00000197390.2 Gm42509 (from geneSymbol) ENSMUST00000197390.1 uc290tnl.1 uc290tnl.2 uc290tnl.1 uc290tnl.2 
ENSMUST00000197391.3 Gm43823 ENSMUST00000197391.3 Gm43823 (from geneSymbol) AK080587 ENSMUST00000197391.1 ENSMUST00000197391.2 uc290jev.1 uc290jev.2 uc290jev.3 uc290jev.1 uc290jev.2 uc290jev.3 
ENSMUST00000197392.2 Gm43618 ENSMUST00000197392.2 Gm43618 (from geneSymbol) AK136902 ENSMUST00000197392.1 uc290knt.1 uc290knt.2 uc290knt.1 uc290knt.2 
ENSMUST00000197397.2 Gm43523 ENSMUST00000197397.2 Gm43523 (from geneSymbol) AK053610 ENSMUST00000197397.1 uc290tfw.1 uc290tfw.2 uc290tfw.1 uc290tfw.2 
ENSMUST00000197406.5 Igkv11-125 ENSMUST00000197406.5 Igkv11-125 (from geneSymbol) A0A0G2JEK4 A0A0G2JEK4_MOUSE ENSMUST00000197406.1 ENSMUST00000197406.2 ENSMUST00000197406.3 ENSMUST00000197406.4 Igkv11-125 uc291fgt.1 uc291fgt.2 uc291fgt.1 uc291fgt.2 
ENSMUST00000197413.5 D030025E07Rik ENSMUST00000197413.5 RIKEN cDNA D030025E07 gene (from RefSeq NR_045704.1) ENSMUST00000197413.1 ENSMUST00000197413.2 ENSMUST00000197413.3 ENSMUST00000197413.4 NR_045704 uc008rht.1 uc008rht.2 uc008rht.3 uc008rht.4 uc008rht.1 uc008rht.2 uc008rht.3 uc008rht.4 
ENSMUST00000197414.2 Gm43236 ENSMUST00000197414.2 Gm43236 (from geneSymbol) ENSMUST00000197414.1 uc292lvd.1 uc292lvd.2 uc292lvd.1 uc292lvd.2 
ENSMUST00000197417.2 ENSMUSG00000121702 ENSMUST00000197417.2 predicted gene 2287 (from RefSeq NR_188786.1) ENSMUST00000197417.1 NR_188786 uc290wsw.1 uc290wsw.2 uc290wsw.1 uc290wsw.2 
ENSMUST00000197421.2 Gm35715 ENSMUST00000197421.2 Gm35715 (from geneSymbol) BC039782 ENSMUST00000197421.1 uc292lrz.1 uc292lrz.2 uc292lrz.1 uc292lrz.2 
ENSMUST00000197422.5 Csn2 ENSMUST00000197422.5 casein beta, transcript variant 1 (from RefSeq NM_009972.2) CASB_MOUSE Csnb ENSMUST00000197422.1 ENSMUST00000197422.2 ENSMUST00000197422.3 ENSMUST00000197422.4 NM_009972 P10598 Q543D9 Q8VCT6 Q8VCU8 Q91VI5 Q922Y5 Q9D1U6 Q9D1U7 uc008xyu.1 uc008xyu.2 uc008xyu.3 uc008xyu.4 Important role in determination of the surface properties of the casein micelles. Secreted. Mammary gland specific. Secreted in milk. Belongs to the beta-casein family. cysteine-type endopeptidase inhibitor activity extracellular region extracellular space lactation negative regulation of lactation negative regulation of cysteine-type endopeptidase activity uc008xyu.1 uc008xyu.2 uc008xyu.3 uc008xyu.4 
ENSMUST00000197423.3 Mir7055 ENSMUST00000197423.3 microRNA 7055 (from RefSeq NR_106022.1) ENSMUST00000197423.1 ENSMUST00000197423.2 NR_106022 uc033izg.1 uc033izg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033izg.1 uc033izg.2 
ENSMUST00000197429.5 Igkv7-33 ENSMUST00000197429.5 Igkv7-33 (from geneSymbol) A0A0G2JDJ8 A0A0G2JDJ8_MOUSE ENSMUST00000197429.1 ENSMUST00000197429.2 ENSMUST00000197429.3 ENSMUST00000197429.4 Igkv7-33 uc291fmy.1 uc291fmy.2 uc291fmy.1 uc291fmy.2 
ENSMUST00000197433.5 Trav15n-1 ENSMUST00000197433.5 Trav15n-1 (from geneSymbol) A0A0G2JGU6 A0A0G2JGU6_MOUSE ENSMUST00000197433.1 ENSMUST00000197433.2 ENSMUST00000197433.3 ENSMUST00000197433.4 Trav15n-1 X02935 uc288tyv.1 uc288tyv.2 uc288tyv.1 uc288tyv.2 
ENSMUST00000197440.5 Slc7a7 ENSMUST00000197440.5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 7, transcript variant 1 (from RefSeq NM_011405.4) ENSMUST00000197440.1 ENSMUST00000197440.2 ENSMUST00000197440.3 ENSMUST00000197440.4 NM_011405 Q9QWS1 Q9Z1K8 Slc7a7 YLAT1_MOUSE uc007tvw.1 uc007tvw.2 uc007tvw.3 uc007tvw.4 Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:9878049). Also mediates L-arginine transport in non- polarized cells, such as monocytes, and is essential for the correct function of these cells (By similarity). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity). Reaction=L-arginine(in) + L-leucine(out) + Na(+)(out) = L-arginine(out) + L-leucine(in) + Na(+)(in); Xref=Rhea:RHEA:70831, ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:57427; Evidence=; Reaction=L-leucine(out) + L-lysine(in) + Na(+)(out) = L-leucine(in) + L-lysine(out) + Na(+)(in); Xref=Rhea:RHEA:74971, ChEBI:CHEBI:29101, ChEBI:CHEBI:32551, ChEBI:CHEBI:57427; Evidence=; Reaction=L-leucine(out) + L-ornithine(in) + Na(+)(out) = L-leucine(in) + L-ornithine(out) + Na(+)(in); Xref=Rhea:RHEA:74963, ChEBI:CHEBI:29101, ChEBI:CHEBI:46911, ChEBI:CHEBI:57427; Evidence=; Kinetic parameters: KM=91.5 uM for L-arginine (in the absence of NaCl) ; KM=340.8 uM for L-arginine (in the presence of 0.1 M NaCl) ; KM=21.7 uM for L-leucine (in the presence of 0.1 M NaCl) ; KM=1.36 mM for L-alanine (in the presence of 0.1 M NaCl) ; KM=47.9 uM for L-leucine (in the presence of 0.1 M LiCl) ; Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc. Basolateral cell membrane ; Multi-pass membrane protein Strongly expressed in kidney and intestine. Weaker expression observed in epididymis, testis, ovary, thyroid pancreas, sub-gland and liver. A mouse model for human lysinuric protein intolerance (LPI), where homozygous knockout mice for Slc7a7 gene are born at a frequency lower than the expected Mendelian ratio (PubMed:17376816). Only two homozygous mice survived, whereas 16 of them died within 24 hours of birth (PubMed:17376816). Growth retardation is an ongoing feature of the two surviving mice kept on a low-protein diet with citrulline supplementation. After a planned withdrawal of the special diet both mice show an acute metabolic derangement, identical to that found in human LPI, leading to death of both animals after severe hyperammonemic neurological symptoms (PubMed:17376816). Tamoxifen-inducible Slc7a7 homozygous knockout mice model resembles the human LPI phenotype, including malabsorption and impaired reabsorption of cationic amino acid (CAA), hypoargininemia and hyperammonemia. Mice also develops pulmonar alveolar proteinosis (PAP) and neurological impairment (PubMed:31653080). Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. regulation of arginine metabolic process plasma membrane amino acid transport basic amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity membrane integral component of membrane basolateral plasma membrane transmembrane transporter activity transmembrane transport L-alpha-amino acid transmembrane transport basic amino acid transmembrane transport uc007tvw.1 uc007tvw.2 uc007tvw.3 uc007tvw.4 
ENSMUST00000197445.2 Gm43111 ENSMUST00000197445.2 Gm43111 (from geneSymbol) ENSMUST00000197445.1 uc290svm.1 uc290svm.2 uc290svm.1 uc290svm.2 
ENSMUST00000197448.2 Igkv4-58 ENSMUST00000197448.2 Igkv4-58 (from geneSymbol) A0A0G2JGI6 A0A0G2JGI6_MOUSE DQ372769 ENSMUST00000197448.1 Igkv4-58 uc291flf.1 uc291flf.2 immunoglobulin production extracellular space immune response uc291flf.1 uc291flf.2 
ENSMUST00000197455.2 Gm43412 ENSMUST00000197455.2 Gm43412 (from geneSymbol) ENSMUST00000197455.1 uc290znh.1 uc290znh.2 uc290znh.1 uc290znh.2 
ENSMUST00000197457.5 Gm36814 ENSMUST00000197457.5 Gm36814 (from geneSymbol) AK030154 ENSMUST00000197457.1 ENSMUST00000197457.2 ENSMUST00000197457.3 ENSMUST00000197457.4 uc008xka.1 uc008xka.2 uc008xka.3 uc008xka.1 uc008xka.2 uc008xka.3 
ENSMUST00000197461.3 Mir129b ENSMUST00000197461.3 microRNA 129b (from RefSeq NR_106139.1) ENSMUST00000197461.1 ENSMUST00000197461.2 NR_106139 uc033hos.1 uc033hos.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hos.1 uc033hos.2 
ENSMUST00000197472.2 Gm43133 ENSMUST00000197472.2 Gm43133 (from geneSymbol) AK086785 ENSMUST00000197472.1 uc290zqg.1 uc290zqg.2 uc290zqg.1 uc290zqg.2 
ENSMUST00000197479.3 Gm25820 ENSMUST00000197479.3 Gm25820 (from geneSymbol) ENSMUST00000197479.1 ENSMUST00000197479.2 uc290gqm.1 uc290gqm.2 uc290gqm.1 uc290gqm.2 
ENSMUST00000197492.3 Gm38509 ENSMUST00000197492.3 predicted gene, 38509 (from RefSeq NR_110488.1) ENSMUST00000197492.1 ENSMUST00000197492.2 NR_110488 uc033hsx.1 uc033hsx.2 uc033hsx.3 uc033hsx.1 uc033hsx.2 uc033hsx.3 
ENSMUST00000197494.2 Gm42862 ENSMUST00000197494.2 Gm42862 (from geneSymbol) ENSMUST00000197494.1 uc290vrh.1 uc290vrh.2 uc290vrh.1 uc290vrh.2 
ENSMUST00000197499.2 7330423F06Rik ENSMUST00000197499.2 7330423F06Rik (from geneSymbol) ENSMUST00000197499.1 LF194841 uc290tae.1 uc290tae.2 uc290tae.1 uc290tae.2 
ENSMUST00000197507.2 Gm43185 ENSMUST00000197507.2 Gm43185 (from geneSymbol) ENSMUST00000197507.1 uc290kpq.1 uc290kpq.2 uc290kpq.1 uc290kpq.2 
ENSMUST00000197508.2 Gm42908 ENSMUST00000197508.2 Gm42908 (from geneSymbol) AK079021 ENSMUST00000197508.1 uc290zpl.1 uc290zpl.2 uc290zpl.1 uc290zpl.2 
ENSMUST00000197510.2 Gm43410 ENSMUST00000197510.2 Gm43410 (from geneSymbol) AK042868 ENSMUST00000197510.1 uc290jck.1 uc290jck.2 uc290jck.1 uc290jck.2 
ENSMUST00000197514.2 Gm42939 ENSMUST00000197514.2 Gm42939 (from geneSymbol) ENSMUST00000197514.1 uc290ica.1 uc290ica.2 uc290ica.1 uc290ica.2 
ENSMUST00000197515.2 Igkv17-121 ENSMUST00000197515.2 Igkv17-121 (from geneSymbol) A0A0G2JFA8 A0A0G2JFA8_MOUSE ENSMUST00000197515.1 Igkv17-121 uc291fgy.1 uc291fgy.2 immunoglobulin production extracellular space immune response uc291fgy.1 uc291fgy.2 
ENSMUST00000197518.2 Iglv2 ENSMUST00000197518.2 Iglv2 (from geneSymbol) BC106995 ENSMUST00000197518.1 LV2A_MOUSE P01728 uc289dhc.1 uc289dhc.2 adaptive immune response immune system process immunoglobulin production extracellular space immune response immunoglobulin complex uc289dhc.1 uc289dhc.2 
ENSMUST00000197523.3 Gm42945 ENSMUST00000197523.3 Gm42945 (from geneSymbol) ENSMUST00000197523.1 ENSMUST00000197523.2 uc290zzf.1 uc290zzf.2 uc290zzf.3 uc290zzf.1 uc290zzf.2 uc290zzf.3 
ENSMUST00000197524.2 Gm43718 ENSMUST00000197524.2 Gm43718 (from geneSymbol) ENSMUST00000197524.1 uc290tfk.1 uc290tfk.2 uc290tfk.1 uc290tfk.2 
ENSMUST00000197525.2 Igkv8-28 ENSMUST00000197525.2 Igkv8-28 (from geneSymbol) A0A0G2JE47 A0A0G2JE47_MOUSE ENSMUST00000197525.1 Igkv8-28 X59816 uc291fng.1 uc291fng.2 immunoglobulin production extracellular space immune response uc291fng.1 uc291fng.2 
ENSMUST00000197530.2 Gm43088 ENSMUST00000197530.2 Gm43088 (from geneSymbol) ENSMUST00000197530.1 LF194228 uc290kaj.1 uc290kaj.2 uc290kaj.1 uc290kaj.2 
ENSMUST00000197532.2 Gm43676 ENSMUST00000197532.2 Gm43676 (from geneSymbol) ENSMUST00000197532.1 uc290yhn.1 uc290yhn.2 uc290yhn.1 uc290yhn.2 
ENSMUST00000197537.2 Ighv1-76 ENSMUST00000197537.2 Ighv1-76 (from geneSymbol) A0A0G2JFE9 A0A0G2JFE9_MOUSE ENSMUST00000197537.1 Ighv1-76 uc288kcu.1 uc288kcu.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kcu.1 uc288kcu.2 
ENSMUST00000197541.2 Gm43180 ENSMUST00000197541.2 Gm43180 (from geneSymbol) AK049094 ENSMUST00000197541.1 uc290vmh.1 uc290vmh.2 uc290vmh.1 uc290vmh.2 
ENSMUST00000197543.3 1700081B01Rik ENSMUST00000197543.3 1700081B01Rik (from geneSymbol) AK006961 ENSMUST00000197543.1 ENSMUST00000197543.2 uc290zzs.1 uc290zzs.2 uc290zzs.3 uc290zzs.1 uc290zzs.2 uc290zzs.3 
ENSMUST00000197548.2 Gm42826 ENSMUST00000197548.2 Gm42826 (from geneSymbol) AB352621 ENSMUST00000197548.1 uc290jkj.1 uc290jkj.2 uc290jkj.1 uc290jkj.2 
ENSMUST00000197549.3 Kif19b ENSMUST00000197549.3 kinesin family member 19B (from RefSeq NM_001378679.1) A0A1B0GSG7 A0A1B0GSG7_MOUSE ENSMUST00000197549.1 ENSMUST00000197549.2 Gm4869 Kif19b NM_001378679 uc291bht.1 uc291bht.2 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding motor activity microtubule motor activity ATP binding kinesin complex microtubule microtubule-based movement microtubule binding ATP-dependent microtubule motor activity, plus-end-directed ATPase activity uc291bht.1 uc291bht.2 
ENSMUST00000197552.2 Gm42675 ENSMUST00000197552.2 Gm42675 (from geneSymbol) AK158880 ENSMUST00000197552.1 uc290tfi.1 uc290tfi.2 uc290tfi.1 uc290tfi.2 
ENSMUST00000197556.2 Gm42483 ENSMUST00000197556.2 Gm42483 (from geneSymbol) AK148960 ENSMUST00000197556.1 uc290vqt.1 uc290vqt.2 uc290vqt.1 uc290vqt.2 
ENSMUST00000197557.2 Trav3n-3 ENSMUST00000197557.2 Trav3n-3 (from geneSymbol) A0A0G2JEM0 A0A0G2JEM0_MOUSE AK042313 ENSMUST00000197557.1 Trav3d-3 Trav3n-3 uc288tzm.1 uc288tzm.2 uc288tzm.1 uc288tzm.2 
ENSMUST00000197559.2 Gm42493 ENSMUST00000197559.2 Gm42493 (from geneSymbol) AK135862 ENSMUST00000197559.1 uc292lmp.1 uc292lmp.2 uc292lmp.1 uc292lmp.2 
ENSMUST00000197560.2 Igkv3-7 ENSMUST00000197560.2 Igkv3-7 (from geneSymbol) A0A0G2JE31 A0A0G2JE31_MOUSE AY648686 ENSMUST00000197560.1 Igkv3-7 uc291fow.1 uc291fow.2 immunoglobulin production extracellular space immune response uc291fow.1 uc291fow.2 
ENSMUST00000197562.2 Gm42536 ENSMUST00000197562.2 Gm42536 (from geneSymbol) ENSMUST00000197562.1 uc290vir.1 uc290vir.2 uc290vir.1 uc290vir.2 
ENSMUST00000197563.2 Gm42608 ENSMUST00000197563.2 Gm42608 (from geneSymbol) AK086226 ENSMUST00000197563.1 uc290fix.1 uc290fix.2 uc290fix.1 uc290fix.2 
ENSMUST00000197564.2 Gm42619 ENSMUST00000197564.2 Gm42619 (from geneSymbol) ENSMUST00000197564.1 uc290xpr.1 uc290xpr.2 uc290xpr.1 uc290xpr.2 
ENSMUST00000197567.5 Adgrl2 ENSMUST00000197567.5 adhesion G protein-coupled receptor L2, transcript variant 22 (from RefSeq NM_001406006.1) A0A0G2JGM8 A0A0G2JGM8_MOUSE Adgrl2 ENSMUST00000197567.1 ENSMUST00000197567.2 ENSMUST00000197567.3 ENSMUST00000197567.4 NM_001406006 uc008rsb.1 uc008rsb.2 uc008rsb.3 Membrane ; Multi- pass membrane protein transmembrane signaling receptor activity G-protein coupled receptor activity signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway membrane integral component of membrane carbohydrate binding uc008rsb.1 uc008rsb.2 uc008rsb.3 
ENSMUST00000197572.2 Gm42457 ENSMUST00000197572.2 Gm42457 (from geneSymbol) ENSMUST00000197572.1 uc290jaf.1 uc290jaf.2 uc290jaf.1 uc290jaf.2 
ENSMUST00000197576.3 1700021F02Rik ENSMUST00000197576.3 1700021F02Rik (from geneSymbol) AK006198 ENSMUST00000197576.1 ENSMUST00000197576.2 uc290xps.1 uc290xps.2 uc290xps.3 uc290xps.1 uc290xps.2 uc290xps.3 
ENSMUST00000197578.3 4921521D15Rik ENSMUST00000197578.3 4921521D15Rik (from geneSymbol) AK014936 ENSMUST00000197578.1 ENSMUST00000197578.2 uc290jbw.1 uc290jbw.2 uc290jbw.3 uc290jbw.1 uc290jbw.2 uc290jbw.3 
ENSMUST00000197581.2 Gm43567 ENSMUST00000197581.2 Gm43567 (from geneSymbol) ENSMUST00000197581.1 uc290wsp.1 uc290wsp.2 uc290wsp.1 uc290wsp.2 
ENSMUST00000197583.2 Gm43023 ENSMUST00000197583.2 Gm43023 (from geneSymbol) ENSMUST00000197583.1 uc290vdp.1 uc290vdp.2 uc290vdp.1 uc290vdp.2 
ENSMUST00000197584.3 Mir376a ENSMUST00000197584.3 microRNA 376a (from RefSeq NR_029877.1) ENSMUST00000197584.1 ENSMUST00000197584.2 NR_029877 uc011ytq.1 uc011ytq.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608711.1 [ECO:0000345] ##Evidence-Data-END## uc011ytq.1 uc011ytq.2 
ENSMUST00000197589.2 Traj59 ENSMUST00000197589.2 Traj59 (from geneSymbol) A0A0G2JF27 A0A0G2JF27_MOUSE ENSMUST00000197589.1 Traj59 uc288uce.1 uc288uce.2 uc288uce.1 uc288uce.2 
ENSMUST00000197593.2 Gm43490 ENSMUST00000197593.2 Gm43490 (from geneSymbol) ENSMUST00000197593.1 uc290thd.1 uc290thd.2 uc290thd.1 uc290thd.2 
ENSMUST00000197594.2 Gm43288 ENSMUST00000197594.2 Gm43288 (from geneSymbol) ENSMUST00000197594.1 uc290jiu.1 uc290jiu.2 uc290jiu.1 uc290jiu.2 
ENSMUST00000197597.2 Gm43246 ENSMUST00000197597.2 Gm43246 (from geneSymbol) ENSMUST00000197597.1 uc290ylc.1 uc290ylc.2 uc290ylc.1 uc290ylc.2 
ENSMUST00000197598.2 Mir684-2 ENSMUST00000197598.2 microRNA 684-2 (from RefSeq NR_030455.1) ENSMUST00000197598.1 NR_030455 uc012dan.1 uc012dan.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012dan.1 uc012dan.2 
ENSMUST00000197609.3 Gm42676 ENSMUST00000197609.3 Gm42676 (from geneSymbol) ENSMUST00000197609.1 ENSMUST00000197609.2 uc290tfh.1 uc290tfh.2 uc290tfh.1 uc290tfh.2 
ENSMUST00000197614.2 Trav14n-2 ENSMUST00000197614.2 Trav14n-2 (from geneSymbol) A0A0G2JDF5 A0A0G2JDF5_MOUSE BC147840 ENSMUST00000197614.1 Trav14d-2 Trav14n-2 uc288tzi.1 uc288tzi.2 uc288tzi.1 uc288tzi.2 
ENSMUST00000197634.2 Gm43781 ENSMUST00000197634.2 Gm43781 (from geneSymbol) ENSMUST00000197634.1 uc290vpf.1 uc290vpf.2 uc290vpf.1 uc290vpf.2 
ENSMUST00000197638.2 F830115B05Rik ENSMUST00000197638.2 F830115B05Rik (from geneSymbol) ENSMUST00000197638.1 uc290yld.1 uc290yld.2 uc290yld.1 uc290yld.2 
ENSMUST00000197639.2 Gm10636 ENSMUST00000197639.2 predicted gene 10636 (from RefSeq NR_033542.1) ENSMUST00000197639.1 NR_033542 uc012czf.1 uc012czf.2 uc012czf.1 uc012czf.2 
ENSMUST00000197640.2 Gm42617 ENSMUST00000197640.2 Gm42617 (from geneSymbol) ENSMUST00000197640.1 LF194956 uc290vlv.1 uc290vlv.2 uc290vlv.1 uc290vlv.2 
ENSMUST00000197641.3 Cldn25 ENSMUST00000197641.3 claudin 25 (from RefSeq NM_001384265.1) ENSMUST00000197641.1 ENSMUST00000197641.2 NM_001384265 uc292hbv.1 uc292hbv.2 uc292hbv.3 uc292hbv.1 uc292hbv.2 uc292hbv.3 
ENSMUST00000197651.3 Mir3535 ENSMUST00000197651.3 microRNA 3535 (from RefSeq NR_106184.1) ENSMUST00000197651.1 ENSMUST00000197651.2 NR_106184 uc033fke.1 uc033fke.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611824.1 [ECO:0000345] ##Evidence-Data-END## uc033fke.1 uc033fke.2 
ENSMUST00000197653.5 Zfp267 ENSMUST00000197653.5 zinc finger protein 267 (from RefSeq NM_001101478.2) A0A0G2JEM5 A0A0G2JEM5_MOUSE D3Ertd254e ENSMUST00000197653.1 ENSMUST00000197653.2 ENSMUST00000197653.3 ENSMUST00000197653.4 NM_001101478 Zfp267 uc008ozg.1 uc008ozg.2 uc008ozg.3 uc008ozg.4 nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc008ozg.1 uc008ozg.2 uc008ozg.3 uc008ozg.4 
ENSMUST00000197656.2 Gm43360 ENSMUST00000197656.2 Gm43360 (from geneSymbol) ENSMUST00000197656.1 uc290zkv.1 uc290zkv.2 uc290zkv.1 uc290zkv.2 
ENSMUST00000197658.2 5430434I15Rik ENSMUST00000197658.2 RIKEN cDNA 5430434I15 gene (from RefSeq NR_040541.1) ENSMUST00000197658.1 NR_040541 uc029ulo.1 uc029ulo.2 uc029ulo.1 uc029ulo.2 
ENSMUST00000197661.2 Gm31887 ENSMUST00000197661.2 Gm31887 (from geneSymbol) AK040028 ENSMUST00000197661.1 uc007pop.1 uc007pop.2 uc007pop.3 uc007pop.1 uc007pop.2 uc007pop.3 
ENSMUST00000197663.2 Gm42684 ENSMUST00000197663.2 Gm42684 (from geneSymbol) AK035214 ENSMUST00000197663.1 uc290szy.1 uc290szy.2 uc290szy.1 uc290szy.2 
ENSMUST00000197669.3 Gm43446 ENSMUST00000197669.3 Gm43446 (from geneSymbol) AK029891 ENSMUST00000197669.1 ENSMUST00000197669.2 uc290kgy.1 uc290kgy.2 uc290kgy.3 uc290kgy.1 uc290kgy.2 uc290kgy.3 
ENSMUST00000197676.2 Gm43815 ENSMUST00000197676.2 Gm43815 (from geneSymbol) AK151407 ENSMUST00000197676.1 uc290wgd.1 uc290wgd.2 uc290wgd.1 uc290wgd.2 
ENSMUST00000197682.6 Gm49027 ENSMUST00000197682.6 Gm49027 (from geneSymbol) A0A0G2JFF0 A0A0G2JFF0_MOUSE A0A286YCG9 BC054109 ENSMUST00000197682.1 ENSMUST00000197682.2 ENSMUST00000197682.3 ENSMUST00000197682.4 ENSMUST00000197682.5 Gm49027 uc290zpx.1 uc290zpx.2 membrane integral component of membrane uc290zpx.1 uc290zpx.2 
ENSMUST00000197685.2 Gm43534 ENSMUST00000197685.2 Gm43534 (from geneSymbol) ENSMUST00000197685.1 uc290huh.1 uc290huh.2 uc290huh.1 uc290huh.2 
ENSMUST00000197696.3 4930573H18Rik ENSMUST00000197696.3 RIKEN cDNA 4930573H18 gene (from RefSeq NR_152120.1) ENSMUST00000197696.1 ENSMUST00000197696.2 NR_152120 uc290hwj.1 uc290hwj.2 uc290hwj.3 uc290hwj.1 uc290hwj.2 uc290hwj.3 
ENSMUST00000197701.2 Gm42551 ENSMUST00000197701.2 Gm42551 (from geneSymbol) AK142970 ENSMUST00000197701.1 uc290vdh.1 uc290vdh.2 uc290vdh.1 uc290vdh.2 
ENSMUST00000197702.2 Gm43006 ENSMUST00000197702.2 Gm43006 (from geneSymbol) ENSMUST00000197702.1 uc290jlh.1 uc290jlh.2 uc290jlh.1 uc290jlh.2 
ENSMUST00000197703.2 Gm43608 ENSMUST00000197703.2 Gm43608 (from geneSymbol) ENSMUST00000197703.1 uc290jet.1 uc290jet.2 uc290jet.1 uc290jet.2 
ENSMUST00000197704.2 Gm42615 ENSMUST00000197704.2 Gm42615 (from geneSymbol) ENSMUST00000197704.1 uc290vlq.1 uc290vlq.2 uc290vlq.1 uc290vlq.2 
ENSMUST00000197710.2 Gm43414 ENSMUST00000197710.2 Gm43414 (from geneSymbol) AK144658 ENSMUST00000197710.1 uc290eto.1 uc290eto.2 uc290eto.1 uc290eto.2 
ENSMUST00000197715.2 Gm42620 ENSMUST00000197715.2 Gm42620 (from geneSymbol) AK085402 ENSMUST00000197715.1 uc290xpw.1 uc290xpw.2 uc290xpw.1 uc290xpw.2 
ENSMUST00000197721.2 Gm43130 ENSMUST00000197721.2 Gm43130 (from geneSymbol) ENSMUST00000197721.1 uc290tfg.1 uc290tfg.2 uc290tfg.1 uc290tfg.2 
ENSMUST00000197729.2 Gm43547 ENSMUST00000197729.2 Gm43547 (from geneSymbol) ENSMUST00000197729.1 uc290xqm.1 uc290xqm.2 uc290xqm.1 uc290xqm.2 
ENSMUST00000197733.2 Gm42660 ENSMUST00000197733.2 Gm42660 (from geneSymbol) ENSMUST00000197733.1 uc290tjv.1 uc290tjv.2 uc290tjv.1 uc290tjv.2 
ENSMUST00000197734.2 Gm42768 ENSMUST00000197734.2 Gm42768 (from geneSymbol) AK142091 ENSMUST00000197734.1 uc290vkl.1 uc290vkl.2 uc290vkl.1 uc290vkl.2 
ENSMUST00000197736.2 Gm42842 ENSMUST00000197736.2 Gm42842 (from geneSymbol) ENSMUST00000197736.1 uc290fjo.1 uc290fjo.2 uc290fjo.1 uc290fjo.2 
ENSMUST00000197740.2 Gm43334 ENSMUST00000197740.2 Gm43334 (from geneSymbol) ENSMUST00000197740.1 LF194245 uc290kjw.1 uc290kjw.2 uc290kjw.1 uc290kjw.2 
ENSMUST00000197747.2 Gm43287 ENSMUST00000197747.2 Gm43287 (from geneSymbol) AK042421 ENSMUST00000197747.1 uc290jis.1 uc290jis.2 uc290jis.1 uc290jis.2 
ENSMUST00000197748.5 Usp33 ENSMUST00000197748.5 ubiquitin specific peptidase 33, transcript variant 1 (from RefSeq NM_133247.3) ENSMUST00000197748.1 ENSMUST00000197748.2 ENSMUST00000197748.3 ENSMUST00000197748.4 NM_133247 Q3UP32 Q5FWK0 Q8K0I3 Q8R5K2 Q99K22 UBP33_MOUSE Vdu1 uc008rti.1 uc008rti.2 uc008rti.3 uc008rti.4 uc008rti.5 Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G- protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Interacts with VHL, leading to its ubiquitination and subsequent degradation (By similarity). Interacts with ARRB1 and ARRB2 (By similarity). Interacts with ADRB2 (By similarity). Interacts with DIO2 (By similarity). Interacts with SELENBP1; in a selenium-dependent manner (By similarity). Interacts with CCP110 (By similarity). Interacts with ROBO1 (PubMed:19684588, PubMed:19706539). Cytoplasm, perinuclear region Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Associates with centrosomes predominantly in S and G2 phases but less in G1 phase (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R5K2-1; Sequence=Displayed; Name=2; IsoId=Q8R5K2-2; Sequence=VSP_038531; Present in 9.5 and 11.5 dpc commissural neurons (at protein level). The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue (By similarity). Ubiquitinated via a VHL-dependent pathway for proteasomal degradation. Belongs to the peptidase C19 family. USP20/USP33 subfamily. Sequence=AAH05506.1; Type=Erroneous initiation; Evidence=; Sequence=AAH89315.1; Type=Erroneous initiation; Evidence=; G-protein coupled receptor binding cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding nucleoplasm cytoplasm Golgi apparatus centrosome microtubule organizing center cytoskeleton focal adhesion proteolysis ubiquitin-dependent protein catabolic process endocytosis axon guidance peptidase activity cysteine-type peptidase activity zinc ion binding regulation of G-protein coupled receptor protein signaling pathway cellular response to starvation regulation of autophagy cell migration protein deubiquitination hydrolase activity Ral GTPase binding negative regulation of protein binding positive regulation of protein binding thiol-dependent ubiquitinyl hydrolase activity cell body metal ion binding perinuclear region of cytoplasm protein stabilization centrosome duplication protein K63-linked deubiquitination protein K48-linked deubiquitination uc008rti.1 uc008rti.2 uc008rti.3 uc008rti.4 uc008rti.5 
ENSMUST00000197752.3 Mir1892 ENSMUST00000197752.3 microRNA 1892 (from RefSeq NR_035439.1) ENSMUST00000197752.1 ENSMUST00000197752.2 NR_035439 uc011ylw.1 uc011ylw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610374.1 [ECO:0000345] ##Evidence-Data-END## uc011ylw.1 uc011ylw.2 
ENSMUST00000197753.2 Gm42919 ENSMUST00000197753.2 Gm42919 (from geneSymbol) ENSMUST00000197753.1 uc290vjw.1 uc290vjw.2 uc290vjw.1 uc290vjw.2 
ENSMUST00000197754.2 Trav6d-6 ENSMUST00000197754.2 Trav6d-6 (from geneSymbol) A0A075B603 A0A075B603_MOUSE ENSMUST00000197754.1 M38678 Trav6-6 Trav6d-6 uc029sje.1 uc029sje.2 uc029sje.3 immunoglobulin production extracellular space immune response uc029sje.1 uc029sje.2 uc029sje.3 
ENSMUST00000197755.3 Mir3068 ENSMUST00000197755.3 microRNA 3068 (from RefSeq NR_037228.1) ENSMUST00000197755.1 ENSMUST00000197755.2 NR_037228 uc011ypm.1 uc011ypm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610878.1 [ECO:0000345] ##Evidence-Data-END## uc011ypm.1 uc011ypm.2 
ENSMUST00000197756.2 Gm42425 ENSMUST00000197756.2 Gm42425 (from geneSymbol) ENSMUST00000197756.1 uc290ztz.1 uc290ztz.2 uc290ztz.1 uc290ztz.2 
ENSMUST00000197760.3 Mir7118 ENSMUST00000197760.3 microRNA 7118 (from RefSeq NR_106066.1) ENSMUST00000197760.1 ENSMUST00000197760.2 NR_106066 uc033gvz.1 uc033gvz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gvz.1 uc033gvz.2 
ENSMUST00000197761.3 4930425O10Rik ENSMUST00000197761.3 RIKEN cDNA 4930425O10 gene (from RefSeq NR_040545.1) ENSMUST00000197761.1 ENSMUST00000197761.2 NR_040545 uc008rno.1 uc008rno.2 uc008rno.3 uc008rno.1 uc008rno.2 uc008rno.3 
ENSMUST00000197762.2 Gm8066 ENSMUST00000197762.2 Gm8066 (from geneSymbol) ENSMUST00000197762.1 uc291avx.1 uc291avx.2 uc291avx.1 uc291avx.2 
ENSMUST00000197774.2 Gm43678 ENSMUST00000197774.2 Gm43678 (from geneSymbol) ENSMUST00000197774.1 uc290kdo.1 uc290kdo.2 uc290kdo.1 uc290kdo.2 
ENSMUST00000197775.2 Gm43648 ENSMUST00000197775.2 Gm43648 (from geneSymbol) ENSMUST00000197775.1 uc290vjr.1 uc290vjr.2 uc290vjr.1 uc290vjr.2 
ENSMUST00000197784.5 Gm42952 ENSMUST00000197784.5 Gm42952 (from geneSymbol) ENSMUST00000197784.1 ENSMUST00000197784.2 ENSMUST00000197784.3 ENSMUST00000197784.4 uc290zzj.1 uc290zzj.2 uc290zzj.1 uc290zzj.2 
ENSMUST00000197792.2 Gm43787 ENSMUST00000197792.2 Gm43787 (from geneSymbol) AK087039 ENSMUST00000197792.1 uc290xov.1 uc290xov.2 uc290xov.1 uc290xov.2 
ENSMUST00000197803.2 Ighv8-9 ENSMUST00000197803.2 Ighv8-9 (from geneSymbol) A0A0G2JET1 A0A0G2JET1_MOUSE ENSMUST00000197803.1 Ighv8-9 uc288kbh.1 uc288kbh.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kbh.1 uc288kbh.2 
ENSMUST00000197810.4 4930555A03Rik ENSMUST00000197810.4 4930555A03Rik (from geneSymbol) ENSMUST00000197810.1 ENSMUST00000197810.2 ENSMUST00000197810.3 KY467956 uc057lgv.1 uc057lgv.2 uc057lgv.3 uc057lgv.4 uc057lgv.5 uc057lgv.1 uc057lgv.2 uc057lgv.3 uc057lgv.4 uc057lgv.5 
ENSMUST00000197811.2 4930511M18Rik ENSMUST00000197811.2 4930511M18Rik (from geneSymbol) AK015762 ENSMUST00000197811.1 uc290hee.1 uc290hee.2 uc290hee.1 uc290hee.2 
ENSMUST00000197815.3 Mir7073 ENSMUST00000197815.3 microRNA 7073 (from RefSeq NR_106041.1) ENSMUST00000197815.1 ENSMUST00000197815.2 NR_106041 uc033jgz.1 uc033jgz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jgz.1 uc033jgz.2 
ENSMUST00000197818.3 Gm43388 ENSMUST00000197818.3 Gm43388 (from geneSymbol) AK079984 ENSMUST00000197818.1 ENSMUST00000197818.2 uc289dgx.1 uc289dgx.2 uc289dgx.3 uc289dgx.1 uc289dgx.2 uc289dgx.3 
ENSMUST00000197819.2 9530097N15Rik ENSMUST00000197819.2 9530097N15Rik (from geneSymbol) ENSMUST00000197819.1 uc290ihz.1 uc290ihz.2 uc290ihz.1 uc290ihz.2 
ENSMUST00000197820.5 Igkv1-35 ENSMUST00000197820.5 Igkv1-35 (from geneSymbol) A0A0G2JDE5 A0A0G2JDE5_MOUSE ENSMUST00000197820.1 ENSMUST00000197820.2 ENSMUST00000197820.3 ENSMUST00000197820.4 Igkv1-35 uc291fmt.1 uc291fmt.2 immunoglobulin production extracellular space immune response uc291fmt.1 uc291fmt.2 
ENSMUST00000197831.2 Gm42513 ENSMUST00000197831.2 Gm42513 (from geneSymbol) ENSMUST00000197831.1 LF224434 uc290flc.1 uc290flc.2 uc290flc.1 uc290flc.2 
ENSMUST00000197832.2 Gm42438 ENSMUST00000197832.2 Gm42438 (from geneSymbol) ENSMUST00000197832.1 uc291ahp.1 uc291ahp.2 uc291ahp.1 uc291ahp.2 
ENSMUST00000197835.2 Gm42764 ENSMUST00000197835.2 Gm42764 (from geneSymbol) ENSMUST00000197835.1 uc290uao.1 uc290uao.2 uc290uao.1 uc290uao.2 
ENSMUST00000197836.2 Gm43466 ENSMUST00000197836.2 Gm43466 (from geneSymbol) ENSMUST00000197836.1 LF194105 uc290iaw.1 uc290iaw.2 uc290iaw.1 uc290iaw.2 
ENSMUST00000197838.2 Gm43521 ENSMUST00000197838.2 Gm43521 (from geneSymbol) AK195010 ENSMUST00000197838.1 uc290jax.1 uc290jax.2 uc290jax.1 uc290jax.2 
ENSMUST00000197839.2 Gm42565 ENSMUST00000197839.2 Gm42565 (from geneSymbol) ENSMUST00000197839.1 uc290vtt.1 uc290vtt.2 uc290vtt.1 uc290vtt.2 
ENSMUST00000197846.2 Gm43535 ENSMUST00000197846.2 Gm43535 (from geneSymbol) ENSMUST00000197846.1 uc292ltd.1 uc292ltd.2 uc292ltd.1 uc292ltd.2 
ENSMUST00000197848.2 A430072C10Rik ENSMUST00000197848.2 A430072C10Rik (from geneSymbol) ENSMUST00000197848.1 uc290jsu.1 uc290jsu.2 uc290jsu.1 uc290jsu.2 
ENSMUST00000197851.2 Gm43814 ENSMUST00000197851.2 Gm43814 (from geneSymbol) ENSMUST00000197851.1 uc292ltv.1 uc292ltv.2 uc292ltv.1 uc292ltv.2 
ENSMUST00000197852.3 Gm38413 ENSMUST00000197852.3 Gm38413 (from geneSymbol) AK044041 ENSMUST00000197852.1 ENSMUST00000197852.2 uc290xkg.1 uc290xkg.2 uc290xkg.3 uc290xkg.1 uc290xkg.2 uc290xkg.3 
ENSMUST00000197856.2 C230031I18Rik ENSMUST00000197856.2 C230031I18Rik (from geneSymbol) ENSMUST00000197856.1 uc290jmy.1 uc290jmy.2 uc290jmy.1 uc290jmy.2 
ENSMUST00000197857.3 Mir6925 ENSMUST00000197857.3 microRNA 6925 (from RefSeq NR_105890.1) ENSMUST00000197857.1 ENSMUST00000197857.2 NR_105890 uc033fxp.1 uc033fxp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fxp.1 uc033fxp.2 
ENSMUST00000197859.5 Ube2d3 ENSMUST00000197859.5 ubiquitin-conjugating enzyme E2D 3, transcript variant 1 (from RefSeq NM_025356.5) ENSMUST00000197859.1 ENSMUST00000197859.2 ENSMUST00000197859.3 ENSMUST00000197859.4 NM_025356 Q4QQL2 Q4QQL2_MOUSE Ube2d3 uc008rlp.1 uc008rlp.2 uc008rlp.3 Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence=; Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L- cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.24; Evidence=; Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding ubiquitin-protein transferase activity ATP binding ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity cellular response to cadmium ion cellular response to mercury ion uc008rlp.1 uc008rlp.2 uc008rlp.3 
ENSMUST00000197860.3 Gm22897 ENSMUST00000197860.3 Gm22897 (from geneSymbol) ENSMUST00000197860.1 ENSMUST00000197860.2 uc290svr.1 uc290svr.2 uc290svr.1 uc290svr.2 
ENSMUST00000197862.3 Mir374c ENSMUST00000197862.3 microRNA 374c (from RefSeq NR_037298.1) ENSMUST00000197862.1 ENSMUST00000197862.2 NR_037298 uc012hnh.1 uc012hnh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012hnh.1 uc012hnh.2 
ENSMUST00000197865.2 Gm43056 ENSMUST00000197865.2 Gm43056 (from geneSymbol) AK030034 ENSMUST00000197865.1 uc290wtk.1 uc290wtk.2 uc290wtk.1 uc290wtk.2 
ENSMUST00000197867.2 Gm43348 ENSMUST00000197867.2 Gm43348 (from geneSymbol) ENSMUST00000197867.1 uc290gel.1 uc290gel.2 uc290gel.1 uc290gel.2 
ENSMUST00000197868.2 Gm42544 ENSMUST00000197868.2 Gm42544 (from geneSymbol) ENSMUST00000197868.1 uc290jfr.1 uc290jfr.2 uc290jfr.1 uc290jfr.2 
ENSMUST00000197871.2 Gm43628 ENSMUST00000197871.2 Gm43628 (from geneSymbol) AK149540 ENSMUST00000197871.1 uc290vvi.1 uc290vvi.2 uc290vvi.1 uc290vvi.2 
ENSMUST00000197875.2 Gm42863 ENSMUST00000197875.2 Gm42863 (from geneSymbol) DQ553993 ENSMUST00000197875.1 uc291bsp.1 uc291bsp.2 uc291bsp.1 uc291bsp.2 
ENSMUST00000197881.3 Gm17590 ENSMUST00000197881.3 Gm17590 (from geneSymbol) AK017915 ENSMUST00000197881.1 ENSMUST00000197881.2 uc290ssj.1 uc290ssj.2 uc290ssj.3 uc290ssj.1 uc290ssj.2 uc290ssj.3 
ENSMUST00000197883.2 Gm42966 ENSMUST00000197883.2 Gm42966 (from geneSymbol) AK149232 ENSMUST00000197883.1 uc290vfb.1 uc290vfb.2 uc290vfb.1 uc290vfb.2 
ENSMUST00000197884.3 Gm9857 ENSMUST00000197884.3 Gm9857 (from geneSymbol) AK005845 ENSMUST00000197884.1 ENSMUST00000197884.2 uc290iut.1 uc290iut.2 uc290iut.3 uc290iut.1 uc290iut.2 uc290iut.3 
ENSMUST00000197889.2 Gm43429 ENSMUST00000197889.2 Gm43429 (from geneSymbol) AK085697 ENSMUST00000197889.1 uc290jyq.1 uc290jyq.2 uc290jyq.1 uc290jyq.2 
ENSMUST00000197897.2 Gm43011 ENSMUST00000197897.2 Gm43011 (from geneSymbol) ENSMUST00000197897.1 uc290jle.1 uc290jle.2 uc290jle.1 uc290jle.2 
ENSMUST00000197898.2 ENSMUSG00000121774 ENSMUST00000197898.2 ENSMUSG00000121774 (from geneSymbol) ENSMUST00000197898.1 uc290hhu.1 uc290hhu.2 uc290hhu.1 uc290hhu.2 
ENSMUST00000197902.2 Gm42432 ENSMUST00000197902.2 Gm42432 (from geneSymbol) ENSMUST00000197902.1 uc292loi.1 uc292loi.2 uc292loi.1 uc292loi.2 
ENSMUST00000197906.2 Gm42440 ENSMUST00000197906.2 Gm42440 (from geneSymbol) ENSMUST00000197906.1 uc291ahn.1 uc291ahn.2 uc291ahn.1 uc291ahn.2 
ENSMUST00000197910.2 4933437G19Rik ENSMUST00000197910.2 4933437G19Rik (from geneSymbol) AK017099 ENSMUST00000197910.1 uc290zhu.1 uc290zhu.2 uc290zhu.1 uc290zhu.2 
ENSMUST00000197913.2 Gm42973 ENSMUST00000197913.2 Gm42973 (from geneSymbol) ENSMUST00000197913.1 uc290jmz.1 uc290jmz.2 uc290jmz.1 uc290jmz.2 
ENSMUST00000197919.2 9530034A14Rik ENSMUST00000197919.2 9530034A14Rik (from geneSymbol) AK020584 ENSMUST00000197919.1 uc290kip.1 uc290kip.2 uc290kip.1 uc290kip.2 
ENSMUST00000197921.3 Gm42690 ENSMUST00000197921.3 Gm42690 (from geneSymbol) AK164221 ENSMUST00000197921.1 ENSMUST00000197921.2 uc290xme.1 uc290xme.2 uc290xme.3 uc290xme.1 uc290xme.2 uc290xme.3 
ENSMUST00000197924.2 Gm43317 ENSMUST00000197924.2 Gm43317 (from geneSymbol) AK089840 ENSMUST00000197924.1 uc290vkf.1 uc290vkf.2 uc290vkf.1 uc290vkf.2 
ENSMUST00000197928.5 Dhx30 ENSMUST00000197928.5 DExH-box helicase 30, transcript variant 1 (from RefSeq NM_001252682.1) DHX30_MOUSE ENSMUST00000197928.1 ENSMUST00000197928.2 ENSMUST00000197928.3 ENSMUST00000197928.4 Helg NM_001252682 Q3U4Z4 Q3UFA0 Q3UJS4 Q91WA7 Q99KN7 Q99PU8 uc009rtk.1 uc009rtk.2 uc009rtk.3 uc009rtk.4 RNA-dependent helicase (PubMed:25219788). Plays an important role in the assembly of the mitochondrial large ribosomal subunit (By similarity). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA (By similarity). Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD (PubMed:25219788). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; Identified in a complex with TFAM and SSBP1. Interacts (via N- terminus) with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner. Found in a complex with GRSF1, DDX28, FASTKD2 and FASTKD5. Cytoplasm Mitochondrion Mitochondrion matrix, mitochondrion nucleoid Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. Relocalizes to stress granules upon heat stress. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99PU8-1; Sequence=Displayed; Name=2; IsoId=Q99PU8-2; Sequence=VSP_019747; Name=3; IsoId=Q99PU8-3; Sequence=VSP_019746; Expressed in the heart, brain, spleen, lung, liver, skeletal muscle, kidney, and testis. Expression is strongest in the testis and brain, while the lowest levels of expression are found in the spleen and lung. Detected at low levels of expression at 3.5 and 6.5 days post coitum (dpc). At 7.5 dpc, it is detected in the ectoderm, mesoderm, and ectoplacental cone. By 8.5 dpc, expression is increased, specifically in the central nervous system, neural plate, and neural tube, which remains constant until 10.5 dpc where it decreases. By 11.5 to 15.5 dpc, expression is reduced further in the central nervous system. [Isoform 3]: Phosphorylated on Ser-15. Belongs to the DEAD box helicase family. DEAH subfamily. nucleotide binding nucleic acid binding chromatin binding RNA binding RNA helicase activity double-stranded RNA binding helicase activity ATP binding cytoplasm mitochondrion cytosol central nervous system development hydrolase activity ribonucleoprotein granule ribosome biogenesis mitochondrial nucleoid mitochondrial large ribosomal subunit assembly uc009rtk.1 uc009rtk.2 uc009rtk.3 uc009rtk.4 
ENSMUST00000197929.3 Mir7232 ENSMUST00000197929.3 microRNA 7232 (from RefSeq NR_106091.1) ENSMUST00000197929.1 ENSMUST00000197929.2 NR_106091 uc009cki.1 uc009cki.2 uc009cki.3 uc009cki.4 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc009cki.1 uc009cki.2 uc009cki.3 uc009cki.4 
ENSMUST00000197930.2 Gm43515 ENSMUST00000197930.2 Gm43515 (from geneSymbol) ENSMUST00000197930.1 uc290wxq.1 uc290wxq.2 uc290wxq.1 uc290wxq.2 
ENSMUST00000197932.2 Gm35507 ENSMUST00000197932.2 Gm35507 (from geneSymbol) AK143271 ENSMUST00000197932.1 uc290iny.1 uc290iny.2 uc290iny.1 uc290iny.2 
ENSMUST00000197936.2 Gm42913 ENSMUST00000197936.2 Gm42913 (from geneSymbol) ENSMUST00000197936.1 LF195107 uc290ynu.1 uc290ynu.2 uc290ynu.1 uc290ynu.2 
ENSMUST00000197937.2 Gm43576 ENSMUST00000197937.2 Gm43576 (from geneSymbol) ENSMUST00000197937.1 uc290klt.1 uc290klt.2 uc290klt.1 uc290klt.2 
ENSMUST00000197943.4 Gm47279 ENSMUST00000197943.4 Gm47279 (from geneSymbol) ENSMUST00000197943.1 ENSMUST00000197943.2 ENSMUST00000197943.3 uc287wzn.1 uc287wzn.2 uc287wzn.1 uc287wzn.2 
ENSMUST00000197944.2 Gm43359 ENSMUST00000197944.2 Gm43359 (from geneSymbol) AK142696 ENSMUST00000197944.1 uc290zks.1 uc290zks.2 uc290zks.1 uc290zks.2 
ENSMUST00000197949.2 Traj47 ENSMUST00000197949.2 Traj47 (from geneSymbol) A0A0G2JDH7 A0A0G2JDH7_MOUSE ENSMUST00000197949.1 S72914 Traj47 uc288ucs.1 uc288ucs.2 uc288ucs.1 uc288ucs.2 
ENSMUST00000197951.2 Gm42442 ENSMUST00000197951.2 Gm42442 (from geneSymbol) ENSMUST00000197951.1 uc291ahk.1 uc291ahk.2 uc291ahk.1 uc291ahk.2 
ENSMUST00000197954.2 Trav13d-2 ENSMUST00000197954.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A0G2JF93) A0A0G2JF93 A0A0G2JF93_MOUSE ENSMUST00000197954.1 Trav13d-2 Trav13n-2 uc288txo.1 uc288txo.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc288txo.1 uc288txo.2 
ENSMUST00000197965.2 9130604C24Rik ENSMUST00000197965.2 RIKEN cDNA 9130604C24 gene (from RefSeq NR_190047.1) ENSMUST00000197965.1 NR_190047 uc291avw.1 uc291avw.2 uc291avw.1 uc291avw.2 
ENSMUST00000197966.2 Igkv4-81 ENSMUST00000197966.2 Igkv4-81 (from geneSymbol) A0A0G2JEY5 A0A0G2JEY5_MOUSE D14630 ENSMUST00000197966.1 Igkv4-81 uc291fjt.1 uc291fjt.2 immunoglobulin production extracellular space immune response uc291fjt.1 uc291fjt.2 
ENSMUST00000197967.2 Gm43032 ENSMUST00000197967.2 Gm43032 (from geneSymbol) ENSMUST00000197967.1 uc290tif.1 uc290tif.2 uc290tif.1 uc290tif.2 
ENSMUST00000197969.2 Iglj2 ENSMUST00000197969.2 Iglj2 (from geneSymbol) A0A0G2JDZ1 A0A0G2JDZ1_MOUSE ENSMUST00000197969.1 Iglj2 uc289dgw.1 uc289dgw.2 uc289dgw.1 uc289dgw.2 
ENSMUST00000197971.3 Gm38411 ENSMUST00000197971.3 Gm38411 (from geneSymbol) AK040387 ENSMUST00000197971.1 ENSMUST00000197971.2 uc008qfx.1 uc008qfx.2 uc008qfx.3 uc008qfx.1 uc008qfx.2 uc008qfx.3 
ENSMUST00000197972.2 Gm43219 ENSMUST00000197972.2 Gm43219 (from geneSymbol) ENSMUST00000197972.1 uc290sxi.1 uc290sxi.2 uc290sxi.1 uc290sxi.2 
ENSMUST00000197975.3 Gm42823 ENSMUST00000197975.3 Gm42823 (from geneSymbol) ENSMUST00000197975.1 ENSMUST00000197975.2 uc290jka.1 uc290jka.2 uc290jka.3 uc290jka.1 uc290jka.2 uc290jka.3 
ENSMUST00000197976.2 Gm42496 ENSMUST00000197976.2 Gm42496 (from geneSymbol) ENSMUST00000197976.1 uc291aay.1 uc291aay.2 uc291aay.1 uc291aay.2 
ENSMUST00000197991.2 Gm43331 ENSMUST00000197991.2 Gm43331 (from geneSymbol) ENSMUST00000197991.1 uc290ila.1 uc290ila.2 uc290ila.1 uc290ila.2 
ENSMUST00000197992.2 Lhfpl3 ENSMUST00000197992.2 lipoma HMGIC fusion partner-like 3, transcript variant 3 (from RefSeq NM_001359998.2) A0A0G2JGI3 A0A0G2JGI3_MOUSE ENSMUST00000197992.1 Lhfpl3 NM_001359998 uc012dst.1 uc012dst.2 uc012dst.3 Membrane ; Multi- pass membrane protein membrane integral component of membrane uc012dst.1 uc012dst.2 uc012dst.3 
ENSMUST00000197995.2 Gm21149 ENSMUST00000197995.2 predicted gene, 21149 (from RefSeq NM_001374725.1) A0A0G2JFY7 A0A0G2JFY7_MOUSE ENSMUST00000197995.1 Gm21149 NM_001374725 uc290tgn.1 uc290tgn.2 uc290tgn.1 uc290tgn.2 
ENSMUST00000197996.2 Gm43520 ENSMUST00000197996.2 Gm43520 (from geneSymbol) AB350634 ENSMUST00000197996.1 uc290jaw.1 uc290jaw.2 uc290jaw.1 uc290jaw.2 
ENSMUST00000197999.2 Gm42681 ENSMUST00000197999.2 Gm42681 (from geneSymbol) AK030618 ENSMUST00000197999.1 uc290idr.1 uc290idr.2 uc290idr.1 uc290idr.2 
ENSMUST00000198002.2 Gm43192 ENSMUST00000198002.2 Gm43192 (from geneSymbol) ENSMUST00000198002.1 uc290jvw.1 uc290jvw.2 uc290jvw.1 uc290jvw.2 
ENSMUST00000198006.3 Mir1897 ENSMUST00000198006.3 microRNA 1897 (from RefSeq NR_035433.1) ENSMUST00000198006.1 ENSMUST00000198006.2 NR_035433 uc012cos.1 uc012cos.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012cos.1 uc012cos.2 
ENSMUST00000198011.3 Gm43403 ENSMUST00000198011.3 Gm43403 (from geneSymbol) ENSMUST00000198011.1 ENSMUST00000198011.2 LF194227 uc290jzz.1 uc290jzz.2 uc290jzz.3 uc290jzz.1 uc290jzz.2 uc290jzz.3 
ENSMUST00000198012.2 Gm43420 ENSMUST00000198012.2 Gm43420 (from geneSymbol) ENSMUST00000198012.1 uc290zfa.1 uc290zfa.2 uc290zfa.1 uc290zfa.2 
ENSMUST00000198013.2 Gm42671 ENSMUST00000198013.2 Gm42671 (from geneSymbol) ENSMUST00000198013.1 uc290hpp.1 uc290hpp.2 uc290hpp.1 uc290hpp.2 
ENSMUST00000198015.2 ENSMUSG00000121396 ENSMUST00000198015.2 ENSMUSG00000121396 (from geneSymbol) ENSMUST00000198015.1 uc292lms.1 uc292lms.2 uc292lms.1 uc292lms.2 
ENSMUST00000198019.2 Trav7-1 ENSMUST00000198019.2 Trav7-1 (from geneSymbol) A0A0G2JEV5 A0A0G2JEV5_MOUSE ENSMUST00000198019.1 Trav7-1 uc288twh.1 uc288twh.2 uc288twh.1 uc288twh.2 
ENSMUST00000198021.2 Gm43727 ENSMUST00000198021.2 Gm43727 (from geneSymbol) ENSMUST00000198021.1 uc290swd.1 uc290swd.2 uc290swd.1 uc290swd.2 
ENSMUST00000198028.2 Gm42880 ENSMUST00000198028.2 Gm42880 (from geneSymbol) ENSMUST00000198028.1 uc290jtq.1 uc290jtq.2 uc290jtq.1 uc290jtq.2 
ENSMUST00000198033.3 Mir6896 ENSMUST00000198033.3 microRNA 6896 (from RefSeq NR_105861.1) ENSMUST00000198033.1 ENSMUST00000198033.2 NR_105861 uc033fij.1 uc033fij.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fij.1 uc033fij.2 
ENSMUST00000198035.2 Gm42893 ENSMUST00000198035.2 Gm42893 (from geneSymbol) ENSMUST00000198035.1 uc290jae.1 uc290jae.2 uc290jae.1 uc290jae.2 
ENSMUST00000198036.2 Gm43319 ENSMUST00000198036.2 Gm43319 (from geneSymbol) ENSMUST00000198036.1 uc290vjv.1 uc290vjv.2 uc290vjv.1 uc290vjv.2 
ENSMUST00000198041.2 Gm42463 ENSMUST00000198041.2 Gm42463 (from geneSymbol) ENSMUST00000198041.1 uc290hic.1 uc290hic.2 uc290hic.1 uc290hic.2 
ENSMUST00000198058.2 Trav6-2 ENSMUST00000198058.2 Trav6-2 (from geneSymbol) ENSMUST00000198058.1 Q5R1I4 Q5R1I4_MOUSE TRAV6-2 Trav6-2 uc288twj.1 uc288twj.2 immunoglobulin production extracellular space immune response uc288twj.1 uc288twj.2 
ENSMUST00000198060.2 Gm43848 ENSMUST00000198060.2 Gm43848 (from geneSymbol) ENSMUST00000198060.1 LF194142 uc290ikt.1 uc290ikt.2 uc290ikt.1 uc290ikt.2 
ENSMUST00000198065.2 Gm42751 ENSMUST00000198065.2 Gm42751 (from geneSymbol) AK080007 ENSMUST00000198065.1 uc290etx.1 uc290etx.2 uc290etx.1 uc290etx.2 
ENSMUST00000198074.2 C230096K16Rik ENSMUST00000198074.2 C230096K16Rik (from geneSymbol) AK049070 ENSMUST00000198074.1 uc290vue.1 uc290vue.2 uc290vue.1 uc290vue.2 
ENSMUST00000198075.2 Gm43018 ENSMUST00000198075.2 Gm43018 (from geneSymbol) AK142142 ENSMUST00000198075.1 uc291aib.1 uc291aib.2 uc291aib.1 uc291aib.2 
ENSMUST00000198076.5 Fbxw21 ENSMUST00000198076.5 F-box and WD-40 domain protein 21, transcript variant 2 (from RefSeq NM_001382229.1) ENSMUST00000198076.1 ENSMUST00000198076.2 ENSMUST00000198076.3 ENSMUST00000198076.4 Fbxw21 NM_001382229 Q3UWS5 Q3UWS5_MOUSE uc009rsb.1 uc009rsb.2 uc009rsb.3 molecular_function cellular_component biological_process uc009rsb.1 uc009rsb.2 uc009rsb.3 
ENSMUST00000198082.3 Mir7061 ENSMUST00000198082.3 microRNA 7061 (from RefSeq NR_106028.1) ENSMUST00000198082.1 ENSMUST00000198082.2 NR_106028 uc033jco.1 uc033jco.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jco.1 uc033jco.2 
ENSMUST00000198084.2 Gm42443 ENSMUST00000198084.2 Gm42443 (from geneSymbol) AK134337 ENSMUST00000198084.1 uc291ahj.1 uc291ahj.2 uc291ahj.1 uc291ahj.2 
ENSMUST00000198085.2 Gm43745 ENSMUST00000198085.2 Gm43745 (from geneSymbol) ENSMUST00000198085.1 uc290ipm.1 uc290ipm.2 uc290ipm.1 uc290ipm.2 
ENSMUST00000198086.2 Gm42470 ENSMUST00000198086.2 Gm42470 (from geneSymbol) ENSMUST00000198086.1 uc292lrs.1 uc292lrs.2 uc292lrs.1 uc292lrs.2 
ENSMUST00000198092.3 Mir142 ENSMUST00000198092.3 microRNA 142 (from RefSeq NR_029555.1) ENSMUST00000198092.1 ENSMUST00000198092.2 NR_029555 uc011yca.1 uc011yca.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608249.1 [ECO:0000345] ##Evidence-Data-END## uc011yca.1 uc011yca.2 
ENSMUST00000198098.2 Gm43677 ENSMUST00000198098.2 Gm43677 (from geneSymbol) ENSMUST00000198098.1 uc290yhm.1 uc290yhm.2 uc290yhm.1 uc290yhm.2 
ENSMUST00000198100.2 Gm43560 ENSMUST00000198100.2 Gm43560 (from geneSymbol) AK087677 ENSMUST00000198100.1 uc290khd.1 uc290khd.2 uc290khd.1 uc290khd.2 
ENSMUST00000198104.2 Gm42699 ENSMUST00000198104.2 Gm42699 (from geneSymbol) ENSMUST00000198104.1 uc290iic.1 uc290iic.2 uc290iic.1 uc290iic.2 
ENSMUST00000198111.2 ENSMUSG00000121775 ENSMUST00000198111.2 ENSMUSG00000121775 (from geneSymbol) ENSMUST00000198111.1 uc290hid.1 uc290hid.2 uc290hid.1 uc290hid.2 
ENSMUST00000198115.3 Mir1843b ENSMUST00000198115.3 microRNA 1843b (from RefSeq NR_039543.1) ENSMUST00000198115.1 ENSMUST00000198115.2 NR_039543 uc287myu.1 uc287myu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc287myu.1 uc287myu.2 
ENSMUST00000198123.2 Gm43444 ENSMUST00000198123.2 Gm43444 (from geneSymbol) ENSMUST00000198123.1 uc290jdj.1 uc290jdj.2 uc290jdj.1 uc290jdj.2 
ENSMUST00000198124.5 Gm30275 ENSMUST00000198124.5 Gm30275 (from geneSymbol) ENSMUST00000198124.1 ENSMUST00000198124.2 ENSMUST00000198124.3 ENSMUST00000198124.4 uc288ubr.1 uc288ubr.2 uc288ubr.1 uc288ubr.2 
ENSMUST00000198130.2 Gm43186 ENSMUST00000198130.2 Gm43186 (from geneSymbol) AK048075 ENSMUST00000198130.1 uc291aie.1 uc291aie.2 uc291aie.1 uc291aie.2 
ENSMUST00000198132.3 Gm33050 ENSMUST00000198132.3 Gm33050 (from geneSymbol) AK045907 ENSMUST00000198132.1 ENSMUST00000198132.2 uc290xhk.1 uc290xhk.2 uc290xhk.3 uc290xhk.1 uc290xhk.2 uc290xhk.3 
ENSMUST00000198140.5 Pfkfb4 ENSMUST00000198140.5 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, transcript variant 3 (from RefSeq NR_153430.1) ENSMUST00000198140.1 ENSMUST00000198140.2 ENSMUST00000198140.3 ENSMUST00000198140.4 F264_MOUSE NR_153430 Q5UD55 Q5UD56 Q5UD57 Q5Y296 Q6DTY7 Q6PFE8 uc009rri.1 uc009rri.2 uc009rri.3 Synthesis and degradation of fructose 2,6-bisphosphate. Reaction=beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate; Xref=Rhea:RHEA:17289, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634, ChEBI:CHEBI:58579; EC=3.1.3.46; Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6- bisphosphate + H(+); Xref=Rhea:RHEA:15653, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57634, ChEBI:CHEBI:58579, ChEBI:CHEBI:456216; EC=2.7.1.105; The most important regulatory mechanism of these opposing activities is by phosphorylation and dephosphorylation of the enzyme. Homodimer. Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q6DTY7-1; Sequence=Displayed; Name=2; IsoId=Q6DTY7-2; Sequence=VSP_021959; Name=3; IsoId=Q6DTY7-3; Sequence=VSP_021964; Name=4; IsoId=Q6DTY7-4; Sequence=VSP_021962, VSP_021963; Name=5; IsoId=Q6DTY7-5; Sequence=VSP_021961; Name=6; IsoId=Q6DTY7-6; Sequence=VSP_021960; In the C-terminal section; belongs to the phosphoglycerate mutase family. nucleotide binding catalytic activity 6-phosphofructo-2-kinase activity fructose-2,6-bisphosphate 2-phosphatase activity ATP binding cytosol fructose metabolic process fructose 2,6-bisphosphate metabolic process metabolic process kinase activity phosphorylation dephosphorylation transferase activity hydrolase activity carbohydrate phosphorylation uc009rri.1 uc009rri.2 uc009rri.3 
ENSMUST00000198145.3 1700008B11Rik ENSMUST00000198145.3 1700008B11Rik (from geneSymbol) AK005752 ENSMUST00000198145.1 ENSMUST00000198145.2 uc290zht.1 uc290zht.2 uc290zht.3 uc290zht.1 uc290zht.2 uc290zht.3 
ENSMUST00000198148.2 C030015E24Rik ENSMUST00000198148.2 C030015E24Rik (from geneSymbol) AK021085 ENSMUST00000198148.1 uc290vke.1 uc290vke.2 uc290vke.1 uc290vke.2 
ENSMUST00000198153.3 Mir409 ENSMUST00000198153.3 microRNA 409 (from RefSeq NR_029913.1) ENSMUST00000198153.1 ENSMUST00000198153.2 NR_029913 uc011yuh.1 uc011yuh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608802.1 [ECO:0000345] ##Evidence-Data-END## uc011yuh.1 uc011yuh.2 
ENSMUST00000198159.3 1700016F12Rik ENSMUST00000198159.3 1700016F12Rik (from geneSymbol) AK006025 ENSMUST00000198159.1 ENSMUST00000198159.2 uc290xhy.1 uc290xhy.2 uc290xhy.3 uc290xhy.1 uc290xhy.2 uc290xhy.3 
ENSMUST00000198162.2 Gm43149 ENSMUST00000198162.2 Gm43149 (from geneSymbol) ENSMUST00000198162.1 uc290igq.1 uc290igq.2 uc290igq.1 uc290igq.2 
ENSMUST00000198163.2 Trgc3 ENSMUST00000198163.2 Trgc3 (from geneSymbol) A0A0G2JG12 A0A0G2JG12_MOUSE ENSMUST00000198163.1 Tcrg-C3 Trgc3 uc288lbx.1 uc288lbx.2 uc288lbx.1 uc288lbx.2 
ENSMUST00000198169.2 4633401B06Rik ENSMUST00000198169.2 4633401B06Rik (from geneSymbol) ENSMUST00000198169.1 uc290jff.1 uc290jff.2 uc290jff.1 uc290jff.2 
ENSMUST00000198171.2 Gm36211 ENSMUST00000198171.2 Gm36211 (from geneSymbol) AK052120 ENSMUST00000198171.1 uc290iph.1 uc290iph.2 uc290iph.1 uc290iph.2 
ENSMUST00000198173.2 Gm42527 ENSMUST00000198173.2 Gm42527 (from geneSymbol) ENSMUST00000198173.1 uc292lvb.1 uc292lvb.2 uc292lvb.1 uc292lvb.2 
ENSMUST00000198176.2 Gm19666 ENSMUST00000198176.2 Gm19666 (from geneSymbol) AK134947 ENSMUST00000198176.1 uc057bti.1 uc057bti.2 uc057bti.1 uc057bti.2 
ENSMUST00000198178.2 C130075A20Rik ENSMUST00000198178.2 C130075A20Rik (from geneSymbol) AK081767 ENSMUST00000198178.1 uc290ffe.1 uc290ffe.2 uc290ffe.1 uc290ffe.2 
ENSMUST00000198182.2 Iglc2 ENSMUST00000198182.2 Iglc2 (from geneSymbol) ENSMUST00000198182.1 Iglc2 Q99JC1 Q99JC1_MOUSE uc289dgu.1 uc289dgu.2 uc289dgu.1 uc289dgu.2 
ENSMUST00000198184.2 Igkv6-13 ENSMUST00000198184.2 Igkv6-13 (from geneSymbol) A0A0G2JGY3 A0A0G2JGY3_MOUSE AY081860 ENSMUST00000198184.1 Igkv6-13 uc291fol.1 uc291fol.2 immunoglobulin production extracellular space immune response uc291fol.1 uc291fol.2 
ENSMUST00000198187.3 Mir7090 ENSMUST00000198187.3 microRNA 7090 (from RefSeq NR_106058.1) ENSMUST00000198187.1 ENSMUST00000198187.2 NR_106058 uc033jnt.1 uc033jnt.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jnt.1 uc033jnt.2 
ENSMUST00000198191.2 4930449I04Rik ENSMUST00000198191.2 4930449I04Rik (from geneSymbol) ENSMUST00000198191.1 uc290via.1 uc290via.2 uc290via.1 uc290via.2 
ENSMUST00000198192.2 Gm43362 ENSMUST00000198192.2 Gm43362 (from geneSymbol) AK042830 ENSMUST00000198192.1 uc290kwz.1 uc290kwz.2 uc290kwz.1 uc290kwz.2 
ENSMUST00000198193.2 4930429D17Rik ENSMUST00000198193.2 RIKEN cDNA 4930429D17 gene (from RefSeq NR_040699.1) ENSMUST00000198193.1 NR_040699 uc029vjy.1 uc029vjy.2 uc029vjy.1 uc029vjy.2 
ENSMUST00000198195.3 Gm19439 ENSMUST00000198195.3 Gm19439 (from geneSymbol) ENSMUST00000198195.1 ENSMUST00000198195.2 LF193978 uc290gle.1 uc290gle.2 uc290gle.3 uc290gle.1 uc290gle.2 uc290gle.3 
ENSMUST00000198198.2 Gm43063 ENSMUST00000198198.2 Gm43063 (from geneSymbol) ENSMUST00000198198.1 LF270978 uc290ifg.1 uc290ifg.2 uc290ifg.1 uc290ifg.2 
ENSMUST00000198199.5 Mef2c ENSMUST00000198199.5 myocyte enhancer factor 2C, transcript variant 2 (from RefSeq NM_025282.4) ENSMUST00000198199.1 ENSMUST00000198199.2 ENSMUST00000198199.3 ENSMUST00000198199.4 MEF2C_MOUSE Mef2c NM_025282 Q8CFN5 Q8R0H1 Q9D7L0 Q9QW20 uc007rie.1 uc007rie.2 uc007rie.3 uc007rie.4 Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18 (PubMed:11554755). May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1 (By similarity). Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation (By similarity). Interacts with HDAC7 and CARM1 (PubMed:11279209, PubMed:11713257). Interacts with HDAC4, HDAC7 AND HDAC9; the interaction with HDACs represses transcriptional activity (By similarity). Interacts with LPIN1 (PubMed:19753306). Interacts with MYOCD (PubMed:16818234). Interacts with AKAP13 (PubMed:20139090). Interacts with FOXK1; the interaction inhibits MEF2C transactivation activity (PubMed:22956541). Interacts (via N-terminus) with HABP4; this interaction decreases DNA-binding activity of MEF2C in myocardial cells in response to mechanical stress (By similarity). Interacts with JPH2; interaction specifically takes place with the Junctophilin-2 N-terminal fragment cleavage product of JPH2 (PubMed:30409805). Interacts (via MADS box) with SOX18 (PubMed:11554755). Q8CFN5; Q9QZR5: Hipk2; NbExp=5; IntAct=EBI-643797, EBI-366905; Q8CFN5; Q8WUI4: HDAC7; Xeno; NbExp=2; IntAct=EBI-643797, EBI-1048378; Q8CFN5-4; Q91V92: Acly; NbExp=3; IntAct=EBI-643822, EBI-644049; Nucleus Cytoplasm, sarcoplasm Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q8CFN5-1; Sequence=Displayed; Name=2; IsoId=Q8CFN5-2; Sequence=VSP_012504; Name=3; IsoId=Q8CFN5-3; Sequence=VSP_012505; Name=4; IsoId=Q8CFN5-4; Sequence=VSP_012501, VSP_012502, VSP_012503, VSP_012504, VSP_012505; Name=5; IsoId=Q8CFN5-5; Sequence=VSP_012501, VSP_012502, VSP_012503; Widely expressed though mainly restricted to skeletal and cardiac muscle, brain, neurons and lymphocytes. Beta domain-lacking isoforms are the most predominantly expressed in all tissues including skeletal and cardiac muscle and brain. Only brain expresses all isoforms. Expression occurs primarily in the internal granule cell layer of the olfactory bulb, cortex, thalamus, hippocampus and cerebellum. Low levels in the cerebellum and hindbrain. Expressed throughout the cortex, including the frontal and entorhinal cortex, dentate gyrus, and basolateral amygdala. Selectively expressed in B- cells but not in T-cells, and its expression increases as B-cells mature. Expressed in developing endothelial cells and smooth muscle cells, as well as in surrounding mesenchyme, during embryogenesis. Up-regulated during myogenesis. The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity. Phosphorylation on Ser-59 enhances DNA binding activity (By similarity). Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity. Acetylated by p300 on several sites in diffentiating myocytes (By similarity). Acetylation on Lys-4 increases DNA binding and transactivation. Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity. Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5- mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation (By similarity). Mice show impairment in hippocampal-dependent learning and also increase in the number of excitatory synapses and potentiation of basal and evoked synaptic transmission. Mice surviving to adulthood manifest smaller, apparently less mature neurons and smaller whole brain size, with resultant aberrant electrophysiology and behavior. Mice exhibit thrombocytopenia and a defect in B- lymphopoiesis. Belongs to the MEF2 family. negative regulation of transcription from RNA polymerase II promoter MAPK cascade nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding blood vessel development osteoblast differentiation neuron migration B cell homeostasis heart looping endochondral ossification blood vessel remodeling chondrocyte differentiation germinal center formation regulation of germinal center formation primary heart field specification secondary heart field specification outflow tract morphogenesis sinoatrial valve morphogenesis cardiac ventricle formation DNA binding AT DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated apoptotic process humoral immune response multicellular organism development nervous system development heart development skeletal muscle tissue development muscle cell fate determination learning or memory transcription factor binding positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression positive regulation of alkaline phosphatase activity neural crest cell differentiation cardiac muscle hypertrophy in response to stress myotube differentiation sarcoplasm nuclear speck sarcomere cell differentiation neuron differentiation platelet formation monocyte differentiation negative regulation of ossification melanocyte differentiation positive regulation of bone mineralization positive regulation of B cell proliferation macromolecular complex activating transcription factor binding cellular response to drug skeletal muscle cell differentiation cellular response to trichostatin A B cell proliferation histone deacetylase binding intracellular membrane-bounded organelle regulation of neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration sequence-specific DNA binding transcription regulatory region DNA binding cell fate commitment regulation of megakaryocyte differentiation positive regulation of myoblast differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of neurotransmitter secretion protein heterodimerization activity protein dimerization activity regulation of synaptic plasticity positive regulation of skeletal muscle tissue development neuron development cell morphogenesis involved in neuron differentiation embryonic viscerocranium morphogenesis embryonic skeletal system morphogenesis negative regulation of epithelial cell proliferation B cell receptor signaling pathway smooth muscle cell differentiation regulation of synapse assembly regulation of synaptic transmission, glutamatergic cardiac muscle cell differentiation ventricular cardiac muscle cell differentiation palate development regulation of synaptic activity positive regulation of cardiac muscle cell proliferation excitatory postsynaptic potential transdifferentiation regulation of sarcomere organization cartilage morphogenesis regulation of dendritic spine development renal tubule morphogenesis cellular response to lipopolysaccharide cellular response to calcium ion cellular response to retinoic acid cellular response to growth factor stimulus cellular response to parathyroid hormone stimulus cellular response to fluid shear stress cellular response to transforming growth factor beta stimulus HMG box domain binding positive regulation of cell proliferation in bone marrow glomerulus morphogenesis nephron tubule epithelial cell differentiation postsynapse negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration negative regulation of vascular endothelial cell proliferation positive regulation of macrophage apoptotic process regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity positive regulation of cardiac muscle cell differentiation positive regulation of behavioral fear response epithelial cell proliferation involved in renal tubule morphogenesis positive regulation of skeletal muscle cell differentiation uc007rie.1 uc007rie.2 uc007rie.3 uc007rie.4 
ENSMUST00000198200.2 Gm43073 ENSMUST00000198200.2 Gm43073 (from geneSymbol) ENSMUST00000198200.1 uc290hxc.1 uc290hxc.2 uc290hxc.1 uc290hxc.2 
ENSMUST00000198203.3 Mir3084-2 ENSMUST00000198203.3 microRNA 3084-2 (from RefSeq NR_105743.1) ENSMUST00000198203.1 ENSMUST00000198203.2 NR_105743 uc012bjt.1 uc012bjt.2 uc012bjt.3 uc012bjt.4 uc012bjt.5 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012bjt.1 uc012bjt.2 uc012bjt.3 uc012bjt.4 uc012bjt.5 
ENSMUST00000198213.3 Mir3960 ENSMUST00000198213.3 microRNA 3960 (from RefSeq NR_039536.1) ENSMUST00000198213.1 ENSMUST00000198213.2 NR_039536 uc029twr.1 uc029twr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029twr.1 uc029twr.2 
ENSMUST00000198221.2 Gm43797 ENSMUST00000198221.2 Gm43797 (from geneSymbol) ENSMUST00000198221.1 uc290zqv.1 uc290zqv.2 uc290zqv.1 uc290zqv.2 
ENSMUST00000198230.2 Gm42947 ENSMUST00000198230.2 Gm42947 (from geneSymbol) ENSMUST00000198230.1 uc290kum.1 uc290kum.2 uc290kum.1 uc290kum.2 
ENSMUST00000198231.3 4930539C22Rik ENSMUST00000198231.3 RIKEN cDNA 4930539C22 gene (from RefSeq NR_040600.1) ENSMUST00000198231.1 ENSMUST00000198231.2 NR_040600 uc029uot.1 uc029uot.2 uc029uot.3 uc029uot.1 uc029uot.2 uc029uot.3 
ENSMUST00000198234.2 Igkj2 ENSMUST00000198234.2 Igkj2 (from geneSymbol) A0A0G2JDG2 A0A0G2JDG2_MOUSE ENSMUST00000198234.1 Igkj2 uc291fpf.1 uc291fpf.2 uc291fpf.1 uc291fpf.2 
ENSMUST00000198236.2 Gm43692 ENSMUST00000198236.2 Gm43692 (from geneSymbol) AK141646 ENSMUST00000198236.1 uc290ulh.1 uc290ulh.2 uc290ulh.1 uc290ulh.2 
ENSMUST00000198237.2 Gm43148 ENSMUST00000198237.2 Gm43148 (from geneSymbol) ENSMUST00000198237.1 uc290xie.1 uc290xie.2 uc290xie.1 uc290xie.2 
ENSMUST00000198240.2 9830132P13Rik ENSMUST00000198240.2 RIKEN cDNA 9830132P13 gene (from RefSeq NR_040552.1) ENSMUST00000198240.1 NR_040552 uc008rhs.1 uc008rhs.2 uc008rhs.3 uc008rhs.1 uc008rhs.2 uc008rhs.3 
ENSMUST00000198244.2 Gm19409 ENSMUST00000198244.2 Gm19409 (from geneSymbol) ENSMUST00000198244.1 uc290uaw.1 uc290uaw.2 uc290uaw.1 uc290uaw.2 
ENSMUST00000198251.2 Gm43713 ENSMUST00000198251.2 Gm43713 (from geneSymbol) ENSMUST00000198251.1 uc290grj.1 uc290grj.2 uc290grj.1 uc290grj.2 
ENSMUST00000198256.2 Gm43144 ENSMUST00000198256.2 Gm43144 (from geneSymbol) AK087020 ENSMUST00000198256.1 uc290xif.1 uc290xif.2 uc290xif.1 uc290xif.2 
ENSMUST00000198260.2 Gm42537 ENSMUST00000198260.2 Gm42537 (from geneSymbol) ENSMUST00000198260.1 uc290viw.1 uc290viw.2 uc290viw.1 uc290viw.2 
ENSMUST00000198265.5 Ambn ENSMUST00000198265.5 ameloblastin, transcript variant 1 (from RefSeq NM_001303431.1) Ambn ENSMUST00000198265.1 ENSMUST00000198265.2 ENSMUST00000198265.3 ENSMUST00000198265.4 NM_001303431 Q5M8P3 Q5M8P3_MOUSE uc008xzs.1 uc008xzs.2 uc008xzs.3 uc008xzs.4 uc008xzs.5 This gene encodes an extracellular matrix glycoprotein that is involved in the formation of dental enamel. Mice lacking the encoded protein fail to undergo normal ameloblast differentiation and develop enamel. Mice overproducing the product of this gene develop thinner and more porous enamel, with disrupted rod patterns and abnormal crystallites. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]. Involved in the mineralization and structural organization of enamel. Secreted, extracellular space, extracellular matrix Belongs to the ameloblastin family. structural constituent of tooth enamel odontogenesis of dentin-containing tooth uc008xzs.1 uc008xzs.2 uc008xzs.3 uc008xzs.4 uc008xzs.5 
ENSMUST00000198271.5 Pheta1 ENSMUST00000198271.5 PH domain containing endocytic trafficking adaptor 1, transcript variant 3 (from RefSeq NM_001359950.1) ENSMUST00000198271.1 ENSMUST00000198271.2 ENSMUST00000198271.3 ENSMUST00000198271.4 Fam109a NM_001359950 Pheta1 Q8BH49 SESQ1_MOUSE uc008zkk.1 uc008zkk.2 uc008zkk.3 Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. Forms homodimers and heterodimers with PHETA2. Interacts with OCRL and INPP5B (By similarity). Interaction with OCRL may be important for endosomal morphology and function (By similarity). Early endosome Recycling endosome Golgi apparatus, trans-Golgi network Cytoplasmic vesicle, clathrin-coated vesicle Note=Interaction with OCRL may be crucial for targeting to endosome and to the trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes. The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B. Was named after 'sesquipedalian', an unnecessarily long description of a simple thing. Belongs to the sesquipedalian family. receptor recycling endosome early endosome Golgi apparatus trans-Golgi network cytosol endosome organization clathrin-coated vesicle cytoplasmic vesicle retrograde transport, endosome to Golgi protein homodimerization activity recycling endosome uc008zkk.1 uc008zkk.2 uc008zkk.3 
ENSMUST00000198276.2 2310074N15Rik ENSMUST00000198276.2 2310074N15Rik (from geneSymbol) AK010155 ENSMUST00000198276.1 uc290tru.1 uc290tru.2 uc290tru.1 uc290tru.2 
ENSMUST00000198280.2 Gm43804 ENSMUST00000198280.2 Gm43804 (from geneSymbol) ENSMUST00000198280.1 uc290fff.1 uc290fff.2 uc290fff.1 uc290fff.2 
ENSMUST00000198286.2 6430500D05Rik ENSMUST00000198286.2 6430500D05Rik (from geneSymbol) AK018278 ENSMUST00000198286.1 uc290fft.1 uc290fft.2 uc290fft.1 uc290fft.2 
ENSMUST00000198290.2 Gm43346 ENSMUST00000198290.2 Gm43346 (from geneSymbol) ENSMUST00000198290.1 uc290gdh.1 uc290gdh.2 uc290gdh.1 uc290gdh.2 
ENSMUST00000198292.2 Gm43162 ENSMUST00000198292.2 Gm43162 (from geneSymbol) AK084543 ENSMUST00000198292.1 uc290kde.1 uc290kde.2 uc290kde.1 uc290kde.2 
ENSMUST00000198296.2 Gm43017 ENSMUST00000198296.2 Gm43017 (from geneSymbol) ENSMUST00000198296.1 uc290ssq.1 uc290ssq.2 uc290ssq.1 uc290ssq.2 
ENSMUST00000198297.2 Trav14-1 ENSMUST00000198297.2 Trav14-1 (from geneSymbol) A0A0G2JF94 A0A0G2JF94_MOUSE BC147823 ENSMUST00000198297.1 Trav14-1 uc288uaj.1 uc288uaj.2 uc288uaj.1 uc288uaj.2 
ENSMUST00000198298.2 Gm43114 ENSMUST00000198298.2 Gm43114 (from geneSymbol) AF059259 ENSMUST00000198298.1 uc290vfo.1 uc290vfo.2 uc290vfo.1 uc290vfo.2 
ENSMUST00000198299.2 Gm43335 ENSMUST00000198299.2 Gm43335 (from geneSymbol) ENSMUST00000198299.1 uc290ymy.1 uc290ymy.2 uc290ymy.1 uc290ymy.2 
ENSMUST00000198300.3 Mir378a ENSMUST00000198300.3 microRNA 378a (from RefSeq NR_029879.1) ENSMUST00000198300.1 ENSMUST00000198300.2 NR_029879 uc033hhn.1 uc033hhn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc033hhn.1 uc033hhn.2 
ENSMUST00000198310.2 Gm43662 ENSMUST00000198310.2 Gm43662 (from geneSymbol) ENSMUST00000198310.1 uc290tgi.1 uc290tgi.2 uc290tgi.1 uc290tgi.2 
ENSMUST00000198311.5 Sass6 ENSMUST00000198311.5 SAS-6 centriolar assembly protein, transcript variant 1 (from RefSeq NM_028349.3) ENSMUST00000198311.1 ENSMUST00000198311.2 ENSMUST00000198311.3 ENSMUST00000198311.4 NM_028349 Q80UK7 Q9CYT4 SAS6_MOUSE Sas6 Sass6 uc008rcn.1 uc008rcn.2 uc008rcn.3 uc008rcn.4 uc008rcn.5 Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (PubMed:24240477). Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (By similarity). Nine homodimers form a cartwheel structure with an internal diameter of 23 nM and radial spokes connecting to the microtubule triplets. Interacts with FBXW5. Forms a complex with CENPJ and STIL. Interacts with NUP62 and TUBG1 at the centrosome. Interacts with CENATAC; the interaction increases with CENATAC acetylation. Interacts with FZR1; the interaction is regulated by CENATAC and leads to SASS6 proteasomal degradation (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis (By similarity). Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (PubMed:24240477). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80UK7-1; Sequence=Displayed; Name=2; IsoId=Q80UK7-2; Sequence=VSP_013318, VSP_013319; The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring. Ubiquitinated by the SCF(FBXW5) E3 ubiquitin-protein ligase complex during S phase, leading to its degradation and preventing centriole reduplication. Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex, leading to its degradation and preventing centriole reduplication. molecular_function cytoplasm centrosome centriole microtubule organizing center cytosol cytoskeleton cell cycle centriole replication centrosome duplication deuterosome uc008rcn.1 uc008rcn.2 uc008rcn.3 uc008rcn.4 uc008rcn.5 
ENSMUST00000198313.2 Iglj4 ENSMUST00000198313.2 Iglj4 (from geneSymbol) A0A0G2JEG4 A0A0G2JEG4_MOUSE ENSMUST00000198313.1 Iglj4 uc289dgt.1 uc289dgt.2 uc289dgt.1 uc289dgt.2 
ENSMUST00000198317.3 Mir219b ENSMUST00000198317.3 microRNA 219b (from RefSeq NR_106110.1) ENSMUST00000198317.1 ENSMUST00000198317.2 NR_106110 uc033hmg.1 uc033hmg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hmg.1 uc033hmg.2 
ENSMUST00000198328.2 Igkv4-53 ENSMUST00000198328.2 Igkv4-53 (from geneSymbol) A0A0G2JFC6 A0A0G2JFC6_MOUSE ENSMUST00000198328.1 Igkv4-53 JF339152 uc291flu.1 uc291flu.2 immunoglobulin production extracellular space immune response uc291flu.1 uc291flu.2 
ENSMUST00000198330.2 Trgv6 ENSMUST00000198330.2 Trgv6 (from geneSymbol) A0A0G2JEL0 A0A0G2JEL0_MOUSE AK133996 ENSMUST00000198330.1 Tcrg-V6 Trgv6 uc288lbn.1 uc288lbn.2 external side of plasma membrane uc288lbn.1 uc288lbn.2 
ENSMUST00000198333.2 Gm43484 ENSMUST00000198333.2 Gm43484 (from geneSymbol) ENSMUST00000198333.1 uc290eth.1 uc290eth.2 uc290eth.1 uc290eth.2 
ENSMUST00000198336.2 2810428J06Rik ENSMUST00000198336.2 2810428J06Rik (from geneSymbol) AK013182 ENSMUST00000198336.1 uc290jxg.1 uc290jxg.2 uc290jxg.1 uc290jxg.2 
ENSMUST00000198339.3 Gm43251 ENSMUST00000198339.3 Gm43251 (from geneSymbol) AK079755 ENSMUST00000198339.1 ENSMUST00000198339.2 uc290xjq.1 uc290xjq.2 uc290xjq.1 uc290xjq.2 
ENSMUST00000198340.2 Gm43333 ENSMUST00000198340.2 Gm43333 (from geneSymbol) ENSMUST00000198340.1 uc290xqw.1 uc290xqw.2 uc290xqw.1 uc290xqw.2 
ENSMUST00000198342.2 Gm42771 ENSMUST00000198342.2 Gm42771 (from geneSymbol) AK144382 ENSMUST00000198342.1 uc290vko.1 uc290vko.2 uc290vko.1 uc290vko.2 
ENSMUST00000198345.2 Igkv4-62 ENSMUST00000198345.2 Igkv4-62 (from geneSymbol) A0A0G2JDW9 A0A0G2JDW9_MOUSE DQ372804 ENSMUST00000198345.1 Igkv4-62 uc291fky.1 uc291fky.2 immunoglobulin production extracellular space immune response uc291fky.1 uc291fky.2 
ENSMUST00000198349.2 Gm42682 ENSMUST00000198349.2 Gm42682 (from geneSymbol) ENSMUST00000198349.1 uc290idl.1 uc290idl.2 uc290idl.1 uc290idl.2 
ENSMUST00000198351.3 Gm43714 ENSMUST00000198351.3 Gm43714 (from geneSymbol) AK078352 ENSMUST00000198351.1 ENSMUST00000198351.2 uc008pwd.1 uc008pwd.2 uc008pwd.3 uc008pwd.1 uc008pwd.2 uc008pwd.3 
ENSMUST00000198354.2 Gm31243 ENSMUST00000198354.2 Gm31243 (from geneSymbol) ENSMUST00000198354.1 uc290jyu.1 uc290jyu.2 uc290jyu.1 uc290jyu.2 
ENSMUST00000198359.2 Trav13n-1 ENSMUST00000198359.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt A0A0G2JEU8) A0A0G2JEU8 A0A0G2JEU8_MOUSE ENSMUST00000198359.1 Trav13n-1 uc288tyr.1 uc288tyr.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. uc288tyr.1 uc288tyr.2 
ENSMUST00000198374.2 Gm42929 ENSMUST00000198374.2 Gm42929 (from geneSymbol) AK137072 ENSMUST00000198374.1 uc290jei.1 uc290jei.2 uc290jei.1 uc290jei.2 
ENSMUST00000198375.3 Gm43241 ENSMUST00000198375.3 Gm43241 (from geneSymbol) ENSMUST00000198375.1 ENSMUST00000198375.2 uc290idc.1 uc290idc.2 uc290idc.3 uc290idc.1 uc290idc.2 uc290idc.3 
ENSMUST00000198377.3 Mir7238 ENSMUST00000198377.3 microRNA 7238 (from RefSeq NR_106097.1) ENSMUST00000198377.1 ENSMUST00000198377.2 NR_106097 uc033jej.1 uc033jej.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jej.1 uc033jej.2 
ENSMUST00000198380.2 Gm43768 ENSMUST00000198380.2 Gm43768 (from geneSymbol) ENSMUST00000198380.1 uc290hjk.1 uc290hjk.2 uc290hjk.1 uc290hjk.2 
ENSMUST00000198383.2 Gm42944 ENSMUST00000198383.2 Gm42944 (from geneSymbol) ENSMUST00000198383.1 uc290dzk.1 uc290dzk.2 uc290dzk.1 uc290dzk.2 
ENSMUST00000198390.2 Gm43423 ENSMUST00000198390.2 Gm43423 (from geneSymbol) AK037345 ENSMUST00000198390.1 uc290xve.1 uc290xve.2 uc290xve.1 uc290xve.2 
ENSMUST00000198394.2 Gm42752 ENSMUST00000198394.2 Gm42752 (from geneSymbol) ENSMUST00000198394.1 uc290etu.1 uc290etu.2 uc290etu.1 uc290etu.2 
ENSMUST00000198396.3 Mir7214 ENSMUST00000198396.3 microRNA 7214 (from RefSeq NR_106073.1) ENSMUST00000198396.1 ENSMUST00000198396.2 NR_106073 uc008biu.1 uc008biu.2 uc008biu.3 uc008biu.4 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc008biu.1 uc008biu.2 uc008biu.3 uc008biu.4 
ENSMUST00000198397.5 Fbxw15 ENSMUST00000198397.5 Substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes KAT7 ubiquitination and subsequent degradation in collaboration with MAP2K1 kinase, leading to reduced histone H3K14 acetylation and increased cell proliferation. (from UniProt L7N1X6) BC099378 ENSMUST00000198397.1 ENSMUST00000198397.2 ENSMUST00000198397.3 ENSMUST00000198397.4 FBW15_MOUSE Fbxo12J Fbxw15 L7N1X6 Q4FZL6 Q4PLJ2 Q8BI39 uc012hbe.1 uc012hbe.2 uc012hbe.3 Substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes KAT7 ubiquitination and subsequent degradation in collaboration with MAP2K1 kinase, leading to reduced histone H3K14 acetylation and increased cell proliferation. Protein modification; protein ubiquitination. Part of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Interacts with KAT7 and SKP1. Cytoplasm, cytosol doplasmic reticulum Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=L7N1X6-1; Sequence=Displayed; Name=2; IsoId=L7N1X6-2; Sequence=VSP_059276; Specifically expressed in oocytes from follicles of the medullary region of the ovary. Detected at 18 dpc, and then decreases thereafter to a very low level at the day of birth. Detected again at 48 hours postpartum, and then increases at 96 hours until 6 days after birth. Up-regulated in response to bacterial lipopolysaccharides (LPS). molecular_function nucleus cytoplasm endoplasmic reticulum cytosol biological_process protein ubiquitination uc012hbe.1 uc012hbe.2 uc012hbe.3 
ENSMUST00000198398.5 Trac ENSMUST00000198398.5 Trac (from geneSymbol) A0A991BQX6 A0A991BQX6_MOUSE AK131826 ENSMUST00000198398.1 ENSMUST00000198398.2 ENSMUST00000198398.3 ENSMUST00000198398.4 Trac uc288uen.1 uc288uen.2 uc288uen.1 uc288uen.2 
ENSMUST00000198407.2 Gm42775 ENSMUST00000198407.2 Gm42775 (from geneSymbol) ENSMUST00000198407.1 uc292lpx.1 uc292lpx.2 uc292lpx.1 uc292lpx.2 
ENSMUST00000198411.3 Mir299a ENSMUST00000198411.3 microRNA 299a (from RefSeq NR_029650.1) ENSMUST00000198411.1 ENSMUST00000198411.2 NR_029650 uc011yta.1 uc011yta.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM608441.1 [ECO:0000345] ##Evidence-Data-END## uc011yta.1 uc011yta.2 
ENSMUST00000198414.2 Gm42938 ENSMUST00000198414.2 Gm42938 (from geneSymbol) ENSMUST00000198414.1 uc290icb.1 uc290icb.2 uc290icb.1 uc290icb.2 
ENSMUST00000198417.2 Gm42829 ENSMUST00000198417.2 Gm42829 (from geneSymbol) AK049964 ENSMUST00000198417.1 uc290zkk.1 uc290zkk.2 uc290zkk.1 uc290zkk.2 
ENSMUST00000198429.2 Gm42809 ENSMUST00000198429.2 Gm42809 (from geneSymbol) AK054125 ENSMUST00000198429.1 uc290gyb.1 uc290gyb.2 uc290gyb.1 uc290gyb.2 
ENSMUST00000198434.2 Gm42480 ENSMUST00000198434.2 Gm42480 (from geneSymbol) ENSMUST00000198434.1 uc290vqj.1 uc290vqj.2 uc290vqj.1 uc290vqj.2 
ENSMUST00000198435.5 Stap1 ENSMUST00000198435.5 signal transducing adaptor family member 1, transcript variant 1 (from RefSeq NM_019992.4) A6H6C6 ENSMUST00000198435.1 ENSMUST00000198435.2 ENSMUST00000198435.3 ENSMUST00000198435.4 NM_019992 Q3TRM1 Q6PES6 Q9JM90 STAP1_MOUSE uc008xxh.1 uc008xxh.2 uc008xxh.3 uc008xxh.4 May function as an adapter molecule downstream of KIT in the proliferation or differentiation of hematopoietic stem cells. Interacts with URI1; the interaction is phosphorylation- dependent occurs in a growth-dependent manner (By similarity). Interacts with KIT and CSF1R. Nucleus Cytoplasm Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JM90-1; Sequence=Displayed; Name=2; IsoId=Q9JM90-2; Sequence=VSP_013399, VSP_013400; Expression restricted to the bone marrow. Phosphorylated on tyrosine by TEC. Phosphorylated on tyrosine by KIT. phosphotyrosine binding transmembrane receptor protein tyrosine kinase adaptor activity SH3/SH2 adaptor activity macrophage colony-stimulating factor receptor binding protein binding nucleus nucleoplasm cytoplasm mitochondrion transmembrane receptor protein tyrosine kinase signaling pathway response to bacterium positive regulation of gene expression negative regulation of macrophage chemotaxis protein kinase binding myeloid cell differentiation receptor tyrosine kinase binding macromolecular complex signaling adaptor activity negative regulation of phosphorylation intracellular membrane-bounded organelle positive regulation of B cell receptor signaling pathway positive regulation of phagocytosis, engulfment cellular response to lipopolysaccharide negative regulation of ruffle assembly negative regulation of macrophage colony-stimulating factor signaling pathway positive regulation of microglial cell activation positive regulation of non-membrane spanning protein tyrosine kinase activity negative regulation of microglial cell migration positive regulation of microglial cell mediated cytotoxicity positive regulation of actin cytoskeleton reorganization uc008xxh.1 uc008xxh.2 uc008xxh.3 uc008xxh.4 
ENSMUST00000198438.2 Gm42923 ENSMUST00000198438.2 Gm42923 (from geneSymbol) DQ553993 ENSMUST00000198438.1 uc290est.1 uc290est.2 uc290est.1 uc290est.2 
ENSMUST00000198439.5 Trav8d-2 ENSMUST00000198439.5 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. (from UniProt Q5R1B6) ENSMUST00000198439.1 ENSMUST00000198439.2 ENSMUST00000198439.3 ENSMUST00000198439.4 Q5R1B6 Q5R1B6_MOUSE TRAV8-2 Trav8d-2 uc288tye.1 uc288tye.2 Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface. Membrane uc288tye.1 uc288tye.2 
ENSMUST00000198446.2 Gm43259 ENSMUST00000198446.2 Gm43259 (from geneSymbol) AK037700 ENSMUST00000198446.1 uc290iii.1 uc290iii.2 uc290iii.1 uc290iii.2 
ENSMUST00000198450.2 Gm43175 ENSMUST00000198450.2 Gm43175 (from geneSymbol) ENSMUST00000198450.1 uc290vlw.1 uc290vlw.2 uc290vlw.1 uc290vlw.2 
ENSMUST00000198459.2 Gm43326 ENSMUST00000198459.2 Gm43326 (from geneSymbol) AK035921 ENSMUST00000198459.1 uc290gaj.1 uc290gaj.2 uc290gaj.1 uc290gaj.2 
ENSMUST00000198462.2 Gm42587 ENSMUST00000198462.2 Gm42587 (from geneSymbol) AK140939 ENSMUST00000198462.1 uc290joa.1 uc290joa.2 uc290joa.1 uc290joa.2 
ENSMUST00000198467.3 Mir7682 ENSMUST00000198467.3 microRNA 7682 (from RefSeq NR_106150.1) ENSMUST00000198467.1 ENSMUST00000198467.2 NR_106150 uc033fmi.1 uc033fmi.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fmi.1 uc033fmi.2 
ENSMUST00000198471.2 Gm43447 ENSMUST00000198471.2 Gm43447 (from geneSymbol) AK035087 ENSMUST00000198471.1 uc290kgz.1 uc290kgz.2 uc290kgz.1 uc290kgz.2 
ENSMUST00000198473.3 Mir3966 ENSMUST00000198473.3 microRNA 3966 (from RefSeq NR_039547.1) ENSMUST00000198473.1 ENSMUST00000198473.2 NR_039547 uc029ret.1 uc029ret.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029ret.1 uc029ret.2 
ENSMUST00000198476.2 Rprl1 ENSMUST00000198476.2 ribonuclease P RNA-like 1 (from RefSeq NR_004434.3) ENSMUST00000198476.1 NR_004434 uc012end.1 uc012end.2 uc012end.3 uc012end.1 uc012end.2 uc012end.3 
ENSMUST00000198479.3 Mir24-1 ENSMUST00000198479.3 microRNA 24-1 (from RefSeq NR_029575.1) ENSMUST00000198479.1 ENSMUST00000198479.2 NR_029575 uc007qxo.1 uc007qxo.2 uc007qxo.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608311.1 [ECO:0000345] ##Evidence-Data-END## uc007qxo.1 uc007qxo.2 uc007qxo.3 
ENSMUST00000198482.2 Gm43000 ENSMUST00000198482.2 Gm43000 (from geneSymbol) AK036311 ENSMUST00000198482.1 uc290thc.1 uc290thc.2 uc290thc.1 uc290thc.2 
ENSMUST00000198488.2 Gm43805 ENSMUST00000198488.2 Gm43805 (from geneSymbol) ENSMUST00000198488.1 uc290ffi.1 uc290ffi.2 uc290ffi.1 uc290ffi.2 
ENSMUST00000198490.4 Gm44391 ENSMUST00000198490.4 Gm44391 (from geneSymbol) ENSMUST00000198490.1 ENSMUST00000198490.2 ENSMUST00000198490.3 uc292aic.1 uc292aic.2 uc292aic.1 uc292aic.2 
ENSMUST00000198497.2 Gm8953 ENSMUST00000198497.2 Gm8953 (from geneSymbol) ENSMUST00000198497.1 uc290teo.1 uc290teo.2 uc290teo.1 uc290teo.2 
ENSMUST00000198500.2 Gm43031 ENSMUST00000198500.2 Gm43031 (from geneSymbol) ENSMUST00000198500.1 uc290sva.1 uc290sva.2 uc290sva.1 uc290sva.2 
ENSMUST00000198518.5 Lgi1 ENSMUST00000198518.5 leucine-rich repeat LGI family, member 1, transcript variant 1 (from RefSeq NM_020278.3) A0A0G2JFT0 ENSMUST00000198518.1 ENSMUST00000198518.2 ENSMUST00000198518.3 ENSMUST00000198518.4 LGI1_MOUSE Lgi1 NM_020278 Q9JIA1 uc008hji.1 uc008hji.2 uc008hji.3 Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). Oligomer (By similarity). Interacts with KCNA1 within a complex containing KCNA1, KCNA4 and KCNAB1 (By similarity). Part of a complex containing ADAM22, DLG4/PSD95 and CACNG2 (stargazin) (By similarity). Can bind to ADAM11 and ADAM23. Secreted Synapse Cytoplasm [Isoform 1]: Cytoplasm Golgi apparatus Secreted [Isoform 2]: Cytoplasm Endoplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JIA1-1; Sequence=Displayed; Name=2; IsoId=Q9JIA1-3; Sequence=VSP_061731, VSP_061732; Expressed in the brain (at protein level) (PubMed:16787412). Expressed in cerebellar cortex basket cell terminals (at protein level) (PubMed:26269648). Highly expressed in the dentate gyrus and CA3 field of the hippocampus. Glycosylated. receptor binding protein binding extracellular region extracellular space axon guidance cell junction positive regulation of cell growth neuron projection development synaptic cleft synapse positive regulation of synaptic transmission protein homooligomerization glutamatergic synapse neurotransmitter receptor localization to postsynaptic specialization membrane uc008hji.1 uc008hji.2 uc008hji.3 
ENSMUST00000198520.2 Mir1a-2 ENSMUST00000198520.2 microRNA 1a-2 (from RefSeq NR_029781.1) ENSMUST00000198520.1 NR_029781 uc008ebe.1 uc008ebe.2 uc008ebe.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608610.1 [ECO:0000345] ##Evidence-Data-END## uc008ebe.1 uc008ebe.2 uc008ebe.3 
ENSMUST00000198527.5 ENSMUSG00000121477 ENSMUST00000198527.5 ENSMUSG00000121477 (from geneSymbol) BC037267 ENSMUST00000198527.1 ENSMUST00000198527.2 ENSMUST00000198527.3 ENSMUST00000198527.4 uc290eam.1 uc290eam.2 uc290eam.3 uc290eam.4 uc290eam.5 uc290eam.1 uc290eam.2 uc290eam.3 uc290eam.4 uc290eam.5 
ENSMUST00000198528.3 Mir5121 ENSMUST00000198528.3 microRNA 5121 (from RefSeq NR_039581.1) ENSMUST00000198528.1 ENSMUST00000198528.2 NR_039581 uc291ppe.1 uc291ppe.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: JF446421.1, LM611525.1 [ECO:0000345] ##Evidence-Data-END## uc291ppe.1 uc291ppe.2 
ENSMUST00000198533.2 Gm42755 ENSMUST00000198533.2 Gm42755 (from geneSymbol) AK140845 ENSMUST00000198533.1 uc292lmw.1 uc292lmw.2 uc292lmw.1 uc292lmw.2 
ENSMUST00000198535.2 Gm43437 ENSMUST00000198535.2 Gm43437 (from geneSymbol) ENSMUST00000198535.1 uc290fkg.1 uc290fkg.2 uc290fkg.1 uc290fkg.2 
ENSMUST00000198537.2 4930428O21Rik ENSMUST00000198537.2 RIKEN cDNA 4930428O21 gene (from RefSeq NR_045871.1) ENSMUST00000198537.1 NR_045871 uc008ymt.1 uc008ymt.2 uc008ymt.1 uc008ymt.2 
ENSMUST00000198540.2 Gm43300 ENSMUST00000198540.2 Gm43300 (from geneSymbol) AK141125 ENSMUST00000198540.1 uc290jcs.1 uc290jcs.2 uc290jcs.1 uc290jcs.2 
ENSMUST00000198543.2 Gm43240 ENSMUST00000198543.2 Gm43240 (from geneSymbol) ENSMUST00000198543.1 uc290khr.1 uc290khr.2 uc290khr.1 uc290khr.2 
ENSMUST00000198544.2 Gm43328 ENSMUST00000198544.2 Gm43328 (from geneSymbol) AK153605 ENSMUST00000198544.1 uc290ikw.1 uc290ikw.2 uc290ikw.1 uc290ikw.2 
ENSMUST00000198548.2 Gm43773 ENSMUST00000198548.2 Gm43773 (from geneSymbol) ENSMUST00000198548.1 uc290hji.1 uc290hji.2 uc290hji.1 uc290hji.2 
ENSMUST00000198550.2 Gm42502 ENSMUST00000198550.2 Gm42502 (from geneSymbol) ENSMUST00000198550.1 uc291bnn.1 uc291bnn.2 uc291bnn.1 uc291bnn.2 
ENSMUST00000198557.2 Gm31305 ENSMUST00000198557.2 Gm31305 (from geneSymbol) AK080051 ENSMUST00000198557.1 uc290hxp.1 uc290hxp.2 uc290hxp.1 uc290hxp.2 
ENSMUST00000198564.2 Gm43445 ENSMUST00000198564.2 Gm43445 (from geneSymbol) ENSMUST00000198564.1 uc290kgv.1 uc290kgv.2 uc290kgv.1 uc290kgv.2 
ENSMUST00000198568.2 Gm43014 ENSMUST00000198568.2 Gm43014 (from geneSymbol) AK029547 ENSMUST00000198568.1 uc290vli.1 uc290vli.2 uc290vli.1 uc290vli.2 
ENSMUST00000198569.2 Gm43012 ENSMUST00000198569.2 Gm43012 (from geneSymbol) ENSMUST00000198569.1 uc291avo.1 uc291avo.2 uc291avo.1 uc291avo.2 
ENSMUST00000198574.2 Gm42982 ENSMUST00000198574.2 Gm42982 (from geneSymbol) AK039827 ENSMUST00000198574.1 uc008xip.1 uc008xip.2 uc008xip.3 uc008xip.1 uc008xip.2 uc008xip.3 
ENSMUST00000198576.2 Gm42769 ENSMUST00000198576.2 Gm42769 (from geneSymbol) ENSMUST00000198576.1 uc290vkm.1 uc290vkm.2 uc290vkm.1 uc290vkm.2 
ENSMUST00000198578.2 Gm42968 ENSMUST00000198578.2 Gm42968 (from geneSymbol) ENSMUST00000198578.1 uc290kxi.1 uc290kxi.2 uc290kxi.1 uc290kxi.2 
ENSMUST00000198579.2 Gm42429 ENSMUST00000198579.2 Gm42429 (from geneSymbol) ENSMUST00000198579.1 FJ654076 uc290vfc.1 uc290vfc.2 uc290vfc.1 uc290vfc.2 
ENSMUST00000198582.6 Gm3716 ENSMUST00000198582.6 predicted gene 3716 (from RefSeq NR_045078.1) ENSMUST00000198582.1 ENSMUST00000198582.2 ENSMUST00000198582.3 ENSMUST00000198582.4 ENSMUST00000198582.5 NR_045078 uc008xmq.1 uc008xmq.2 uc008xmq.3 uc008xmq.4 uc008xmq.5 uc008xmq.1 uc008xmq.2 uc008xmq.3 uc008xmq.4 uc008xmq.5 
ENSMUST00000198583.2 Gm42767 ENSMUST00000198583.2 Gm42767 (from geneSymbol) ENSMUST00000198583.1 uc290vkk.1 uc290vkk.2 uc290vkk.1 uc290vkk.2 
ENSMUST00000198595.2 Gm42490 ENSMUST00000198595.2 Gm42490 (from geneSymbol) AK052105 ENSMUST00000198595.1 uc290szi.1 uc290szi.2 uc290szi.1 uc290szi.2 
ENSMUST00000198600.2 5830487J09Rik ENSMUST00000198600.2 5830487J09Rik (from geneSymbol) ENSMUST00000198600.1 uc290zph.1 uc290zph.2 uc290zph.1 uc290zph.2 
ENSMUST00000198605.2 Gm43593 ENSMUST00000198605.2 Gm43593 (from geneSymbol) AK033949 ENSMUST00000198605.1 uc290xwn.1 uc290xwn.2 uc290xwn.1 uc290xwn.2 
ENSMUST00000198609.3 Mir7233 ENSMUST00000198609.3 microRNA 7233 (from RefSeq NR_106092.1) ENSMUST00000198609.1 ENSMUST00000198609.2 NR_106092 uc009dwq.1 uc009dwq.2 uc009dwq.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc009dwq.1 uc009dwq.2 uc009dwq.3 
ENSMUST00000198611.2 Gm42625 ENSMUST00000198611.2 Gm42625 (from geneSymbol) AK157115 ENSMUST00000198611.1 uc291aik.1 uc291aik.2 uc291aik.1 uc291aik.2 
ENSMUST00000198613.2 Gm43075 ENSMUST00000198613.2 Gm43075 (from geneSymbol) ENSMUST00000198613.1 uc290hxg.1 uc290hxg.2 uc290hxg.1 uc290hxg.2 
ENSMUST00000198616.2 Gm43667 ENSMUST00000198616.2 Gm43667 (from geneSymbol) ENSMUST00000198616.1 uc290emo.1 uc290emo.2 uc290emo.1 uc290emo.2 
ENSMUST00000198617.2 Gm43338 ENSMUST00000198617.2 Gm43338 (from geneSymbol) ENSMUST00000198617.1 LF195265 uc291bhh.1 uc291bhh.2 uc291bhh.1 uc291bhh.2 
ENSMUST00000198619.2 BB187690 ENSMUST00000198619.2 BB187690 (from geneSymbol) AK138502 ENSMUST00000198619.1 uc290fkj.1 uc290fkj.2 uc290fkj.1 uc290fkj.2 
ENSMUST00000198622.2 Gm43205 ENSMUST00000198622.2 Gm43205 (from geneSymbol) ENSMUST00000198622.1 uc290ept.1 uc290ept.2 uc290ept.1 uc290ept.2 
ENSMUST00000198627.2 Gm42461 ENSMUST00000198627.2 Gm42461 (from geneSymbol) AK075639 ENSMUST00000198627.1 uc290vkv.1 uc290vkv.2 uc290vkv.1 uc290vkv.2 
ENSMUST00000198629.5 Gm4861 ENSMUST00000198629.5 Gm4861 (from geneSymbol) AK079008 ENSMUST00000198629.1 ENSMUST00000198629.2 ENSMUST00000198629.3 ENSMUST00000198629.4 uc008rmm.1 uc008rmm.2 uc008rmm.3 uc008rmm.1 uc008rmm.2 uc008rmm.3 
ENSMUST00000198632.2 2810432F15Rik ENSMUST00000198632.2 2810432F15Rik (from geneSymbol) ENSMUST00000198632.1 uc291ahg.1 uc291ahg.2 uc291ahg.1 uc291ahg.2 
ENSMUST00000198636.2 Gm42881 ENSMUST00000198636.2 Gm42881 (from geneSymbol) ENSMUST00000198636.1 uc290jtm.1 uc290jtm.2 uc290jtm.1 uc290jtm.2 
ENSMUST00000198643.2 Gm43663 ENSMUST00000198643.2 Gm43663 (from geneSymbol) AK138665 ENSMUST00000198643.1 uc290tge.1 uc290tge.2 uc290tge.1 uc290tge.2 
ENSMUST00000198646.2 Ighv1-67 ENSMUST00000198646.2 Ighv1-67 (from geneSymbol) A0A0G2JFN9 A0A0G2JFN9_MOUSE AY648645 ENSMUST00000198646.1 Ighv1-67 uc288kbu.1 uc288kbu.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kbu.1 uc288kbu.2 
ENSMUST00000198647.2 Gm42967 ENSMUST00000198647.2 Gm42967 (from geneSymbol) ENSMUST00000198647.1 uc290kqe.1 uc290kqe.2 uc290kqe.1 uc290kqe.2 
ENSMUST00000198652.3 Mirlet7f-1 ENSMUST00000198652.3 microRNA let7f-1 (from RefSeq NR_029731.1) ENSMUST00000198652.1 ENSMUST00000198652.2 NR_029731 uc011yzc.1 uc011yzc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608560.1 [ECO:0000345] ##Evidence-Data-END## uc011yzc.1 uc011yzc.2 
ENSMUST00000198654.2 Gm42479 ENSMUST00000198654.2 Gm42479 (from geneSymbol) ENSMUST00000198654.1 uc290vqn.1 uc290vqn.2 uc290vqn.1 uc290vqn.2 
ENSMUST00000198656.2 Gm42879 ENSMUST00000198656.2 Gm42879 (from geneSymbol) ENSMUST00000198656.1 LF307725 uc290zge.1 uc290zge.2 uc290zge.1 uc290zge.2 
ENSMUST00000198663.5 Trgv3 ENSMUST00000198663.5 Trgv3 (from geneSymbol) A0A0G2JEW2 A0A0G2JEW2_MOUSE ENSMUST00000198663.1 ENSMUST00000198663.2 ENSMUST00000198663.3 ENSMUST00000198663.4 Tcrg-V3 Trgv3 uc288lbu.1 uc288lbu.2 external side of plasma membrane uc288lbu.1 uc288lbu.2 
ENSMUST00000198665.3 Mir669a-12 ENSMUST00000198665.3 microRNA 669a-12 (from RefSeq NR_037268.1) ENSMUST00000198665.1 ENSMUST00000198665.2 NR_037268 uc056zjw.1 uc056zjw.2 uc056zjw.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zjw.1 uc056zjw.2 uc056zjw.3 
ENSMUST00000198672.2 Gm43665 ENSMUST00000198672.2 Gm43665 (from geneSymbol) ENSMUST00000198672.1 uc290tgj.1 uc290tgj.2 uc290tgj.1 uc290tgj.2 
ENSMUST00000198674.3 Mir3065 ENSMUST00000198674.3 microRNA 3065 (from RefSeq NR_037225.1) ENSMUST00000198674.1 ENSMUST00000198674.2 NR_037225 uc011yiv.1 uc011yiv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610875.1 [ECO:0000345] ##Evidence-Data-END## uc011yiv.1 uc011yiv.2 
ENSMUST00000198676.2 Gm43042 ENSMUST00000198676.2 Gm43042 (from geneSymbol) ENSMUST00000198676.1 uc290vre.1 uc290vre.2 uc290vre.1 uc290vre.2 
ENSMUST00000198677.2 Gm42428 ENSMUST00000198677.2 Gm42428 (from geneSymbol) ENSMUST00000198677.1 uc290vfd.1 uc290vfd.2 uc290vfd.1 uc290vfd.2 
ENSMUST00000198678.2 Gm43034 ENSMUST00000198678.2 Gm43034 (from geneSymbol) ENSMUST00000198678.1 LF195175 uc290zvx.1 uc290zvx.2 uc290zvx.1 uc290zvx.2 
ENSMUST00000198682.2 Trav12n-1 ENSMUST00000198682.2 Trav12n-1 (from geneSymbol) A0N8R0 A0N8R0_MOUSE AK041819 ENSMUST00000198682.1 Trav12d-1 Trav12n-1 uc288typ.1 uc288typ.2 immunoglobulin production molecular_function extracellular space immune response uc288typ.1 uc288typ.2 
ENSMUST00000198686.2 Nwd2os ENSMUST00000198686.2 Nwd2os (from geneSymbol) BC079612 ENSMUST00000198686.1 uc008xmc.1 uc008xmc.2 uc008xmc.3 uc008xmc.1 uc008xmc.2 uc008xmc.3 
ENSMUST00000198691.2 Gm42516 ENSMUST00000198691.2 Gm42516 (from geneSymbol) ENSMUST00000198691.1 uc290ivw.1 uc290ivw.2 uc290ivw.1 uc290ivw.2 
ENSMUST00000198692.3 Gm43021 ENSMUST00000198692.3 Gm43021 (from geneSymbol) ENSMUST00000198692.1 ENSMUST00000198692.2 uc290vdl.1 uc290vdl.2 uc290vdl.3 uc290vdl.1 uc290vdl.2 uc290vdl.3 
ENSMUST00000198696.2 Gm29681 ENSMUST00000198696.2 predicted gene, 29681 (from RefSeq NR_152164.1) ENSMUST00000198696.1 NR_152164 uc291agq.1 uc291agq.2 uc291agq.1 uc291agq.2 
ENSMUST00000198710.3 Mir3967 ENSMUST00000198710.3 microRNA 3967 (from RefSeq NR_039548.1) ENSMUST00000198710.1 ENSMUST00000198710.2 NR_039548 uc029tvy.1 uc029tvy.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029tvy.1 uc029tvy.2 
ENSMUST00000198717.2 Gm43395 ENSMUST00000198717.2 Gm43395 (from geneSymbol) ENSMUST00000198717.1 uc290vrb.1 uc290vrb.2 uc290vrb.1 uc290vrb.2 
ENSMUST00000198718.2 2510017J16Rik ENSMUST00000198718.2 2510017J16Rik (from geneSymbol) AK010976 ENSMUST00000198718.1 uc290ssy.1 uc290ssy.2 uc290ssy.1 uc290ssy.2 
ENSMUST00000198723.2 Gm43344 ENSMUST00000198723.2 Gm43344 (from geneSymbol) ENSMUST00000198723.1 uc290eeq.1 uc290eeq.2 uc290eeq.1 uc290eeq.2 
ENSMUST00000198724.2 Gm42614 ENSMUST00000198724.2 Gm42614 (from geneSymbol) AK140183 ENSMUST00000198724.1 uc290vlp.1 uc290vlp.2 uc290vlp.1 uc290vlp.2 
ENSMUST00000198725.2 Gm43045 ENSMUST00000198725.2 Gm43045 (from geneSymbol) ENSMUST00000198725.1 uc290vqw.1 uc290vqw.2 uc290vqw.1 uc290vqw.2 
ENSMUST00000198729.2 Gm43107 ENSMUST00000198729.2 Gm43107 (from geneSymbol) AK195010 ENSMUST00000198729.1 uc290iyf.1 uc290iyf.2 uc290iyf.1 uc290iyf.2 
ENSMUST00000198731.2 Gm42585 ENSMUST00000198731.2 Gm42585 (from geneSymbol) ENSMUST00000198731.1 uc290tuc.1 uc290tuc.2 uc290tuc.1 uc290tuc.2 
ENSMUST00000198735.2 Igkv10-95 ENSMUST00000198735.2 Igkv10-95 (from geneSymbol) A0A0G2JFY3 A0A0G2JFY3_MOUSE ENSMUST00000198735.1 Igkv10-95 uc291fit.1 uc291fit.2 immunoglobulin production extracellular space immune response uc291fit.1 uc291fit.2 
ENSMUST00000198737.3 Gm43351 ENSMUST00000198737.3 Gm43351 (from geneSymbol) ENSMUST00000198737.1 ENSMUST00000198737.2 uc290jsp.1 uc290jsp.2 uc290jsp.3 uc290jsp.1 uc290jsp.2 uc290jsp.3 
ENSMUST00000198749.2 Gm43527 ENSMUST00000198749.2 Gm43527 (from geneSymbol) ENSMUST00000198749.1 uc290kuz.1 uc290kuz.2 uc290kuz.1 uc290kuz.2 
ENSMUST00000198751.5 Gm6639 ENSMUST00000198751.5 predicted gene 6639 (from RefSeq NR_040748.1) ENSMUST00000198751.1 ENSMUST00000198751.2 ENSMUST00000198751.3 ENSMUST00000198751.4 NR_040748 uc008oyr.1 uc008oyr.2 uc008oyr.1 uc008oyr.2 
ENSMUST00000198756.2 Gm42543 ENSMUST00000198756.2 Gm42543 (from geneSymbol) A0A0G2JET4 A0A0G2JET4_MOUSE ENSMUST00000198756.1 Gm42543 uc291fjj.1 uc291fjj.2 immunoglobulin production extracellular space immune response uc291fjj.1 uc291fjj.2 
ENSMUST00000198760.2 Gm43830 ENSMUST00000198760.2 Gm43830 (from geneSymbol) AB352277 ENSMUST00000198760.1 uc290vju.1 uc290vju.2 uc290vju.1 uc290vju.2 
ENSMUST00000198762.2 Gm31026 ENSMUST00000198762.2 predicted gene, 31026 (from RefSeq NR_166395.1) ENSMUST00000198762.1 NR_166395 uc008pfb.1 uc008pfb.2 uc008pfb.1 uc008pfb.2 
ENSMUST00000198767.2 Gm43706 ENSMUST00000198767.2 Gm43706 (from geneSymbol) ENSMUST00000198767.1 uc290vpy.1 uc290vpy.2 uc290vpy.1 uc290vpy.2 
ENSMUST00000198771.2 Gm43046 ENSMUST00000198771.2 Gm43046 (from geneSymbol) ENSMUST00000198771.1 uc290vki.1 uc290vki.2 uc290vki.1 uc290vki.2 
ENSMUST00000198772.2 Gm43702 ENSMUST00000198772.2 Gm43702 (from geneSymbol) ENSMUST00000198772.1 LF204603 uc291bha.1 uc291bha.2 uc291bha.1 uc291bha.2 
ENSMUST00000198777.2 Ighv1-77 ENSMUST00000198777.2 Ighv1-77 (from geneSymbol) A0A0G2JGS9 A0A0G2JGS9_MOUSE AF045501 ENSMUST00000198777.1 Ighv1-77 uc288kcx.1 uc288kcx.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kcx.1 uc288kcx.2 
ENSMUST00000198787.2 Gm42815 ENSMUST00000198787.2 Gm42815 (from geneSymbol) ENSMUST00000198787.1 LF195257 uc291bdh.1 uc291bdh.2 uc291bdh.1 uc291bdh.2 
ENSMUST00000198795.3 Mir3961 ENSMUST00000198795.3 microRNA 3961 (from RefSeq NR_039537.1) ENSMUST00000198795.1 ENSMUST00000198795.2 NR_039537 uc056yul.1 uc056yul.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yul.1 uc056yul.2 
ENSMUST00000198797.2 Gm43179 ENSMUST00000198797.2 Gm43179 (from geneSymbol) BC127069 ENSMUST00000198797.1 uc290vmi.1 uc290vmi.2 uc290vmi.1 uc290vmi.2 
ENSMUST00000198802.3 Mir3069 ENSMUST00000198802.3 microRNA 3069 (from RefSeq NR_037229.1) ENSMUST00000198802.1 ENSMUST00000198802.2 NR_037229 uc288iye.1 uc288iye.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610879.1 [ECO:0000345] ##Evidence-Data-END## uc288iye.1 uc288iye.2 
ENSMUST00000198804.2 Gm42436 ENSMUST00000198804.2 Gm42436 (from geneSymbol) ENSMUST00000198804.1 uc290ews.1 uc290ews.2 uc290ews.1 uc290ews.2 
ENSMUST00000198813.2 E030032P16Rik ENSMUST00000198813.2 E030032P16Rik (from geneSymbol) DQ543612 ENSMUST00000198813.1 uc290xje.1 uc290xje.2 uc290xje.1 uc290xje.2 
ENSMUST00000198817.2 Gm43728 ENSMUST00000198817.2 Gm43728 (from geneSymbol) ENSMUST00000198817.1 uc290swe.1 uc290swe.2 uc290swe.1 uc290swe.2 
ENSMUST00000198822.2 4930599N24Rik ENSMUST00000198822.2 4930599N24Rik (from geneSymbol) AK016418 ENSMUST00000198822.1 uc290jze.1 uc290jze.2 uc290jze.1 uc290jze.2 
ENSMUST00000198825.2 Gm30835 ENSMUST00000198825.2 Gm30835 (from geneSymbol) ENSMUST00000198825.1 uc290syc.1 uc290syc.2 uc290syc.1 uc290syc.2 
ENSMUST00000198837.3 Vamp9 ENSMUST00000198837.3 vesicle-associated membrane protein 9 (from RefSeq NM_001378420.1) A0A1D5RLS7 A0A1D5RLS7_MOUSE ENSMUST00000198837.1 ENSMUST00000198837.2 Gm35911 NM_001378420 Vamp9 uc290xkm.1 uc290xkm.2 Belongs to the synaptobrevin family. SNARE binding SNAP receptor activity exocytosis vesicle fusion membrane integral component of membrane vesicle-mediated transport SNARE complex uc290xkm.1 uc290xkm.2 
ENSMUST00000198839.3 Mir6915 ENSMUST00000198839.3 microRNA 6915 (from RefSeq NR_105880.1) ENSMUST00000198839.1 ENSMUST00000198839.2 NR_105880 uc033fte.1 uc033fte.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fte.1 uc033fte.2 
ENSMUST00000198844.5 Fbxw14 ENSMUST00000198844.5 F-box and WD-40 domain protein 14, transcript variant 1 (from RefSeq NM_015793.2) ENSMUST00000198844.1 ENSMUST00000198844.2 ENSMUST00000198844.3 ENSMUST00000198844.4 Fbxw14 NM_015793 Q8C2Y5 Q8C2Y5_MOUSE uc009rse.1 uc009rse.2 uc009rse.3 uc009rse.4 molecular_function cellular_component biological_process uc009rse.1 uc009rse.2 uc009rse.3 uc009rse.4 
ENSMUST00000198850.2 Gm43061 ENSMUST00000198850.2 Gm43061 (from geneSymbol) ENSMUST00000198850.1 uc290ify.1 uc290ify.2 uc290ify.1 uc290ify.2 
ENSMUST00000198852.2 Gm43514 ENSMUST00000198852.2 Gm43514 (from geneSymbol) AK083211 ENSMUST00000198852.1 uc290xny.1 uc290xny.2 uc290xny.1 uc290xny.2 
ENSMUST00000198853.2 Gm42633 ENSMUST00000198853.2 Gm42633 (from geneSymbol) AK054374 ENSMUST00000198853.1 uc290zyl.1 uc290zyl.2 uc290zyl.1 uc290zyl.2 
ENSMUST00000198855.2 Gm42722 ENSMUST00000198855.2 Gm42722 (from geneSymbol) ENSMUST00000198855.1 uc290ima.1 uc290ima.2 uc290ima.1 uc290ima.2 
ENSMUST00000198856.2 Gm43549 ENSMUST00000198856.2 Gm43549 (from geneSymbol) ENSMUST00000198856.1 uc290fjb.1 uc290fjb.2 uc290fjb.1 uc290fjb.2 
ENSMUST00000198857.2 Gm43708 ENSMUST00000198857.2 Gm43708 (from geneSymbol) ENSMUST00000198857.1 uc291bjd.1 uc291bjd.2 uc291bjd.1 uc291bjd.2 
ENSMUST00000198859.2 Gm43055 ENSMUST00000198859.2 Gm43055 (from geneSymbol) AK135309 ENSMUST00000198859.1 uc290wtm.1 uc290wtm.2 uc290wtm.1 uc290wtm.2 
ENSMUST00000198860.2 Gm42476 ENSMUST00000198860.2 Gm42476 (from geneSymbol) ENSMUST00000198860.1 uc290gdb.1 uc290gdb.2 uc290gdb.1 uc290gdb.2 
ENSMUST00000198862.3 Mir466e ENSMUST00000198862.3 microRNA 466e (from RefSeq NR_130321.1) ENSMUST00000198862.1 ENSMUST00000198862.2 NR_130321 uc056zjv.1 uc056zjv.2 uc056zjv.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zjv.1 uc056zjv.2 uc056zjv.3 
ENSMUST00000198863.2 Gm42460 ENSMUST00000198863.2 Gm42460 (from geneSymbol) AK139189 ENSMUST00000198863.1 uc056zzs.1 uc056zzs.2 uc056zzs.1 uc056zzs.2 
ENSMUST00000198865.5 Pth1r ENSMUST00000198865.5 parathyroid hormone 1 receptor, transcript variant 1 (from RefSeq NM_011199.2) ENSMUST00000198865.1 ENSMUST00000198865.2 ENSMUST00000198865.3 ENSMUST00000198865.4 NM_011199 P41593 PTH1R_MOUSE Pthr Pthr1 Q62119 Q80WU8 uc009ruq.1 uc009ruq.2 uc009ruq.3 Receptor for parathyroid hormone and for parathyroid hormone- related peptide (PubMed:8197183). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:8197183). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer. Cell membrane ; Multi-pass membrane protein Detected in kidney. N-glycosylated. Belongs to the G-protein coupled receptor 2 family. skeletal system development ossification in utero embryonic development chondrocyte differentiation osteoblast development transmembrane signaling receptor activity G-protein coupled receptor activity parathyroid hormone receptor activity nucleus cytoplasm plasma membrane integral component of plasma membrane cellular calcium ion homeostasis signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration aging positive regulation of cell proliferation negative regulation of cell proliferation G-protein coupled peptide receptor activity membrane integral component of membrane basolateral plasma membrane apical plasma membrane peptide hormone binding bone mineralization brush border membrane protein homodimerization activity receptor complex protein self-association bone resorption cell maturation positive regulation of inositol phosphate biosynthetic process uc009ruq.1 uc009ruq.2 uc009ruq.3 
ENSMUST00000198866.5 Tfr2 ENSMUST00000198866.5 transferrin receptor 2, transcript variant 8 (from RefSeq NM_001425507.1) ENSMUST00000198866.1 ENSMUST00000198866.2 ENSMUST00000198866.3 ENSMUST00000198866.4 NM_001425507 Q920I6 Q99MQ9 Q9CPT2 Q9JKX3 TFR2_MOUSE Trfr2 uc009acv.1 uc009acv.2 uc009acv.3 uc009acv.4 Mediates cellular uptake of transferrin-bound iron in a non- iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Cell membrane; Single-pass type II membrane protein. [Isoform 3]: Cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9JKX3-1; Sequence=Displayed; Name=2; IsoId=Q9JKX3-2; Sequence=VSP_005357, VSP_005358; Name=3; IsoId=Q9JKX3-3; Sequence=VSP_005356; Predominantly expressed in liver. Also expressed in kidney, spleen, brain, lung, heart and muscle with very low expression in kidney, muscle and heart. First expressed between embryo days 8 and 11. In the liver, expression increases during development from embryo day 13 to adulthood while, in the spleen, levels remain constant throughout development. Down-regulated during erythrocyte differentiation. Expression unchanged by cellular iron status. [Isoform 2]: Lacks most of the extracellular domain. Belongs to the peptidase M28 family. M28B subfamily. transferrin receptor activity protein binding cytoplasm plasma membrane integral component of plasma membrane cellular iron ion homeostasis receptor-mediated endocytosis acute-phase response external side of plasma membrane response to iron ion membrane integral component of membrane cytoplasmic vesicle transferrin transport co-receptor binding positive regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter iron ion homeostasis cellular response to iron ion positive regulation of peptide hormone secretion positive regulation of protein maturation HFE-transferrin receptor complex uc009acv.1 uc009acv.2 uc009acv.3 uc009acv.4 
ENSMUST00000198874.2 Gm43488 ENSMUST00000198874.2 Gm43488 (from geneSymbol) ENSMUST00000198874.1 uc290esm.1 uc290esm.2 uc290esm.1 uc290esm.2 
ENSMUST00000198875.2 E430021H15Rik ENSMUST00000198875.2 E430021H15Rik (from geneSymbol) AK040452 ENSMUST00000198875.1 uc008xio.1 uc008xio.2 uc008xio.3 uc008xio.1 uc008xio.2 uc008xio.3 
ENSMUST00000198876.2 Gm43685 ENSMUST00000198876.2 Gm43685 (from geneSymbol) ENSMUST00000198876.1 uc290vmn.1 uc290vmn.2 uc290vmn.1 uc290vmn.2 
ENSMUST00000198878.2 Wls ENSMUST00000198878.2 wntless WNT ligand secretion mediator, transcript variant 3 (from RefSeq NM_001356350.1) ENSMUST00000198878.1 Gpr177 NM_001356350 Q6DID7 Q8CE42 Q9D2B7 WLS_MOUSE uc029upj.1 uc029upj.2 uc029upj.3 Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Also plays an important role in establishment of the anterior-posterior body axis formation during development. Interacts with WNT3A (By similarity). Interacts with WNT1, WNT3 and WNT5. Q6DID7-1; P04426: Wnt1; NbExp=2; IntAct=EBI-15811068, EBI-1570911; Golgi apparatus membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6DID7-1; Sequence=Displayed; Name=2; IsoId=Q6DID7-2; Sequence=VSP_022348; Expressed in the brain, skeletal muscle, heart muscle, lung, gut, liver, and kidney (at protein level) (PubMed:20652957). In the brain, expressed in the cortex, striatum, hippocampus and to a lesser extent in the cerebellum (at protein level) (PubMed:20652957). Expressed in kidney, lung, skin, intestine, brain, spinal cord, skeleton, eyes, excretion glands, tooth and palatal shelves (PubMed:19841259). In the cerebellum, expressed in Purkinje cells (PubMed:19841259). Detected at 6.25 dpc in the proximal epiblast at the junction between the embryonic and extraembryonic tissue. Later expression is more restricted to the primitive streak and mesoderm extending to the distal tip of the embryo. Strong expression is found in both posterior visceral endoderm and epiblast at the prestreak, but switched to the mesoderm at late-streak. Up-regulated by WNT1. Transcriptionally activated by beta- catenin and by LEF/TCF-dependent transcription. N-glycosylated. Mice display embryonic lethality before 10.5 dpc. Embryos show defects in the establishment of the body axis and in the primitive streak and mesoderm formation. Belongs to the wntless family. Sequence=AAH18381.1; Type=Erroneous initiation; Evidence=; Sequence=BAC26266.1; Type=Erroneous initiation; Evidence=; Sequence=BAC26300.1; Type=Erroneous initiation; Evidence=; Sequence=BAC32102.1; Type=Erroneous initiation; Evidence=; Sequence=BAC33950.1; Type=Erroneous initiation; Evidence=; Golgi membrane mesoderm formation protein binding endosome early endosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus trans-Golgi network plasma membrane intracellular protein transport multicellular organism development anterior/posterior axis specification membrane integral component of membrane Wnt signaling pathway Wnt-protein binding positive regulation of Wnt signaling pathway cytoplasmic vesicle membrane midbrain development hindbrain development exocrine pancreas development cytoplasmic vesicle mu-type opioid receptor binding early endosome membrane dendrite membrane dendrite cytoplasm Wnt protein secretion positive regulation of Wnt protein secretion positive regulation of canonical Wnt signaling pathway uc029upj.1 uc029upj.2 uc029upj.3 
ENSMUST00000198880.5 Igkv12-38 ENSMUST00000198880.5 Igkv12-38 (from geneSymbol) A0A0G2JEI7 A0A0G2JEI7_MOUSE ENSMUST00000198880.1 ENSMUST00000198880.2 ENSMUST00000198880.3 ENSMUST00000198880.4 Igkv12-38 uc291fmo.1 uc291fmo.2 immunoglobulin production extracellular space immune response uc291fmo.1 uc291fmo.2 
ENSMUST00000198883.2 Gm42825 ENSMUST00000198883.2 Gm42825 (from geneSymbol) ENSMUST00000198883.1 uc290jkg.1 uc290jkg.2 uc290jkg.1 uc290jkg.2 
ENSMUST00000198885.2 Gm43255 ENSMUST00000198885.2 Gm43255 (from geneSymbol) AK040516 ENSMUST00000198885.1 uc290epy.1 uc290epy.2 uc290epy.1 uc290epy.2 
ENSMUST00000198888.2 Gm42874 ENSMUST00000198888.2 Gm42874 (from geneSymbol) AK033080 ENSMUST00000198888.1 uc290jur.1 uc290jur.2 uc290jur.1 uc290jur.2 
ENSMUST00000198896.3 Mir5615-1 ENSMUST00000198896.3 microRNA 5615-1 (from RefSeq NR_049186.1) ENSMUST00000198896.1 ENSMUST00000198896.2 NR_049186 uc033frj.1 uc033frj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611583.1 [ECO:0000345] ##Evidence-Data-END## uc033frj.1 uc033frj.2 
ENSMUST00000198897.2 Gm43321 ENSMUST00000198897.2 Gm43321 (from geneSymbol) AK135039 ENSMUST00000198897.1 uc290vjx.1 uc290vjx.2 uc290vjx.1 uc290vjx.2 
ENSMUST00000198898.2 Gm35066 ENSMUST00000198898.2 Gm35066 (from geneSymbol) AK035404 ENSMUST00000198898.1 uc290khw.1 uc290khw.2 uc290khw.1 uc290khw.2 
ENSMUST00000198904.2 Gm42482 ENSMUST00000198904.2 Gm42482 (from geneSymbol) ENSMUST00000198904.1 uc290vqk.1 uc290vqk.2 uc290vqk.1 uc290vqk.2 
ENSMUST00000198907.5 4930519H02Rik ENSMUST00000198907.5 RIKEN cDNA 4930519H02 gene (from RefSeq NR_045974.1) ENSMUST00000198907.1 ENSMUST00000198907.2 ENSMUST00000198907.3 ENSMUST00000198907.4 NR_045974 uc008wmu.1 uc008wmu.2 uc008wmu.3 uc008wmu.1 uc008wmu.2 uc008wmu.3 
ENSMUST00000198910.2 Gm6602 ENSMUST00000198910.2 predicted gene 6602 (from RefSeq NR_045362.1) ENSMUST00000198910.1 NR_045362 uc029uof.1 uc029uof.2 uc029uof.1 uc029uof.2 
ENSMUST00000198912.2 Gm6370 ENSMUST00000198912.2 predicted gene 6370, transcript variant 3 (from RefSeq NM_001374732.1) A0A0G2JGX9 A0A0G2JGX9_MOUSE ENSMUST00000198912.1 Gm6370 NM_001374732 uc291btx.1 uc291btx.2 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc291btx.1 uc291btx.2 
ENSMUST00000198913.5 Trav9n-2 ENSMUST00000198913.5 Trav9n-2 (from geneSymbol) A0A0G2JDP3 A0A0G2JDP3_MOUSE BC106771 ENSMUST00000198913.1 ENSMUST00000198913.2 ENSMUST00000198913.3 ENSMUST00000198913.4 Trav9d-2 Trav9n-2 uc288tyy.1 uc288tyy.2 uc288tyy.1 uc288tyy.2 
ENSMUST00000198917.2 Gm42910 ENSMUST00000198917.2 Gm42910 (from geneSymbol) DQ699580 ENSMUST00000198917.1 uc290ten.1 uc290ten.2 uc290ten.1 uc290ten.2 
ENSMUST00000198918.2 Gm43301 ENSMUST00000198918.2 Gm43301 (from geneSymbol) AK136666 ENSMUST00000198918.1 uc290zla.1 uc290zla.2 uc290zla.1 uc290zla.2 
ENSMUST00000198919.3 Mir6924 ENSMUST00000198919.3 microRNA 6924 (from RefSeq NR_105889.1) ENSMUST00000198919.1 ENSMUST00000198919.2 NR_105889 uc033fxk.1 uc033fxk.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fxk.1 uc033fxk.2 
ENSMUST00000198931.2 Cdkl5 ENSMUST00000198931.2 cyclin dependent kinase like 5, transcript variant 2 (from RefSeq NM_001421523.1) A0A0G2JGW6 A0A0G2JGW6_MOUSE Cdkl5 ENSMUST00000198931.1 NM_001421523 uc292roc.1 uc292roc.2 Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. protein kinase activity ATP binding protein phosphorylation uc292roc.1 uc292roc.2 
ENSMUST00000198942.2 Gm43049 ENSMUST00000198942.2 Gm43049 (from geneSymbol) ENSMUST00000198942.1 uc290kdt.1 uc290kdt.2 uc290kdt.1 uc290kdt.2 
ENSMUST00000198943.2 Gm43099 ENSMUST00000198943.2 Gm43099 (from geneSymbol) ENSMUST00000198943.1 uc290irz.1 uc290irz.2 uc290irz.1 uc290irz.2 
ENSMUST00000198949.2 Gm43209 ENSMUST00000198949.2 Gm43209 (from geneSymbol) ENSMUST00000198949.1 uc292lmx.1 uc292lmx.2 uc292lmx.1 uc292lmx.2 
ENSMUST00000198962.2 Gm42817 ENSMUST00000198962.2 Gm42817 (from geneSymbol) ENSMUST00000198962.1 uc291aaz.1 uc291aaz.2 uc291aaz.1 uc291aaz.2 
ENSMUST00000198963.2 Gm43145 ENSMUST00000198963.2 Gm43145 (from geneSymbol) ENSMUST00000198963.1 uc290xih.1 uc290xih.2 uc290xih.1 uc290xih.2 
ENSMUST00000198964.2 Gm42489 ENSMUST00000198964.2 Gm42489 (from geneSymbol) ENSMUST00000198964.1 uc290yia.1 uc290yia.2 uc290yia.1 uc290yia.2 
ENSMUST00000198965.5 Rufy3 ENSMUST00000198965.5 RUN and FYVE domain containing 3, transcript variant 7 (from RefSeq NM_001359209.2) A0A0G2JFT8 A0A0G2JFT8_MOUSE ENSMUST00000198965.1 ENSMUST00000198965.2 ENSMUST00000198965.3 ENSMUST00000198965.4 NM_001359209 Rufy3 uc008xzx.1 uc008xzx.2 uc008xzx.3 uc008xzx.4 cytoplasm cytosol positive regulation of cell migration metal ion binding invadopodium uc008xzx.1 uc008xzx.2 uc008xzx.3 uc008xzx.4 
ENSMUST00000198971.2 Gm43065 ENSMUST00000198971.2 Gm43065 (from geneSymbol) AK041775 ENSMUST00000198971.1 uc290ihj.1 uc290ihj.2 uc290ihj.1 uc290ihj.2 
ENSMUST00000198972.3 Gm26413 ENSMUST00000198972.3 Gm26413 (from geneSymbol) ENSMUST00000198972.1 ENSMUST00000198972.2 uc288drg.1 uc288drg.2 uc288drg.1 uc288drg.2 
ENSMUST00000198978.2 Gm42839 ENSMUST00000198978.2 Gm42839 (from geneSymbol) ENSMUST00000198978.1 uc290zyb.1 uc290zyb.2 uc290zyb.1 uc290zyb.2 
ENSMUST00000198980.3 Mir6902 ENSMUST00000198980.3 microRNA 6902 (from RefSeq NR_105867.1) ENSMUST00000198980.1 ENSMUST00000198980.2 NR_105867 uc033fks.1 uc033fks.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fks.1 uc033fks.2 
ENSMUST00000198985.3 Mir6994 ENSMUST00000198985.3 microRNA 6994 (from RefSeq NR_105960.1) ENSMUST00000198985.1 ENSMUST00000198985.2 NR_105960 uc033hjm.1 uc033hjm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hjm.1 uc033hjm.2 
ENSMUST00000198988.5 Spink8 ENSMUST00000198988.5 serine peptidase inhibitor, Kazal type 8 (from RefSeq NM_183136.2) ENSMUST00000198988.1 ENSMUST00000198988.2 ENSMUST00000198988.3 ENSMUST00000198988.4 ISK8_MOUSE NM_183136 Q09TK9 uc009rsr.1 uc009rsr.2 uc009rsr.3 uc009rsr.4 Probable serine protease inhibitor. Secreted Expressed in epydiymis, in the cauda, corpus and caput. serine-type endopeptidase inhibitor activity extracellular region negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc009rsr.1 uc009rsr.2 uc009rsr.3 uc009rsr.4 
ENSMUST00000198989.2 Gm42616 ENSMUST00000198989.2 Gm42616 (from geneSymbol) ENSMUST00000198989.1 uc290vlu.1 uc290vlu.2 uc290vlu.1 uc290vlu.2 
ENSMUST00000198991.3 Mir6947 ENSMUST00000198991.3 microRNA 6947 (from RefSeq NR_105912.1) ENSMUST00000198991.1 ENSMUST00000198991.2 NR_105912 uc033gox.1 uc033gox.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gox.1 uc033gox.2 
ENSMUST00000198992.2 Gm42697 ENSMUST00000198992.2 Gm42697 (from geneSymbol) AK044569 ENSMUST00000198992.1 uc290jqf.1 uc290jqf.2 uc290jqf.1 uc290jqf.2 
ENSMUST00000198998.3 Mir6906 ENSMUST00000198998.3 microRNA 6906 (from RefSeq NR_105871.1) ENSMUST00000198998.1 ENSMUST00000198998.2 NR_105871 uc033fph.1 uc033fph.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fph.1 uc033fph.2 
ENSMUST00000199006.2 Gm43080 ENSMUST00000199006.2 Gm43080 (from geneSymbol) AK136903 ENSMUST00000199006.1 uc057bpq.1 uc057bpq.2 uc057bpq.1 uc057bpq.2 
ENSMUST00000199015.2 Gm43005 ENSMUST00000199015.2 Gm43005 (from geneSymbol) AK085977 ENSMUST00000199015.1 uc290jli.1 uc290jli.2 uc290jli.1 uc290jli.2 
ENSMUST00000199017.2 Trgv5 ENSMUST00000199017.2 Trgv5 (from geneSymbol) A0A0G2JGV5 A0A0G2JGV5_MOUSE ENSMUST00000199017.1 Tcrg-V5 Trgv5 uc288lbp.1 uc288lbp.2 external side of plasma membrane cell periphery uc288lbp.1 uc288lbp.2 
ENSMUST00000199027.2 Gm43750 ENSMUST00000199027.2 Gm43750 (from geneSymbol) ENSMUST00000199027.1 uc290jmn.1 uc290jmn.2 uc290jmn.1 uc290jmn.2 
ENSMUST00000199042.3 Gm43824 ENSMUST00000199042.3 Gm43824 (from geneSymbol) AK039527 ENSMUST00000199042.1 ENSMUST00000199042.2 uc290jpb.1 uc290jpb.2 uc290jpb.3 uc290jpb.1 uc290jpb.2 uc290jpb.3 
ENSMUST00000199047.2 Gm43670 ENSMUST00000199047.2 Gm43670 (from geneSymbol) ENSMUST00000199047.1 uc290vkr.1 uc290vkr.2 uc290vkr.1 uc290vkr.2 
ENSMUST00000199056.2 A930003O13Rik ENSMUST00000199056.2 RIKEN cDNA A930003O13 gene (from RefSeq NR_027362.1) ENSMUST00000199056.1 NR_027362 uc012dss.1 uc012dss.2 uc012dss.3 uc012dss.4 uc012dss.1 uc012dss.2 uc012dss.3 uc012dss.4 
ENSMUST00000199058.3 4933401H06Rik ENSMUST00000199058.3 RIKEN cDNA 4933401H06 gene (from RefSeq NR_040540.1) ENSMUST00000199058.1 ENSMUST00000199058.2 NR_040540 uc029uou.1 uc029uou.2 uc029uou.3 uc029uou.4 uc029uou.1 uc029uou.2 uc029uou.3 uc029uou.4 
ENSMUST00000199063.2 Gm42629 ENSMUST00000199063.2 Gm42629 (from geneSymbol) AB351567 ENSMUST00000199063.1 uc290jpr.1 uc290jpr.2 uc290jpr.1 uc290jpr.2 
ENSMUST00000199071.2 Gm42700 ENSMUST00000199071.2 Gm42700 (from geneSymbol) ENSMUST00000199071.1 uc290iib.1 uc290iib.2 uc290iib.1 uc290iib.2 
ENSMUST00000199075.2 Gm42687 ENSMUST00000199075.2 Gm42687 (from geneSymbol) AB350634 ENSMUST00000199075.1 uc290iye.1 uc290iye.2 uc290iye.1 uc290iye.2 
ENSMUST00000199077.3 Mir126b ENSMUST00000199077.3 microRNA 126b (from RefSeq NR_106155.1) ENSMUST00000199077.1 ENSMUST00000199077.2 NR_106155 uc033hmb.1 uc033hmb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hmb.1 uc033hmb.2 
ENSMUST00000199080.2 Gm42503 ENSMUST00000199080.2 Gm42503 (from geneSymbol) DQ569474 ENSMUST00000199080.1 uc291boc.1 uc291boc.2 uc291boc.1 uc291boc.2 
ENSMUST00000199082.2 Gm43081 ENSMUST00000199082.2 Gm43081 (from geneSymbol) AK038214 ENSMUST00000199082.1 uc290xyj.1 uc290xyj.2 uc290xyj.1 uc290xyj.2 
ENSMUST00000199084.2 Gm43609 ENSMUST00000199084.2 Gm43609 (from geneSymbol) AK032785 ENSMUST00000199084.1 uc290jfc.1 uc290jfc.2 uc290jfc.1 uc290jfc.2 
ENSMUST00000199085.2 Gm42948 ENSMUST00000199085.2 Gm42948 (from geneSymbol) ENSMUST00000199085.1 uc290tne.1 uc290tne.2 uc290tne.1 uc290tne.2 
ENSMUST00000199094.3 Mir7210 ENSMUST00000199094.3 microRNA 7210 (from RefSeq NR_106069.1) ENSMUST00000199094.1 ENSMUST00000199094.2 NR_106069 uc033gop.1 uc033gop.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611812.1 [ECO:0000345] ##Evidence-Data-END## uc033gop.1 uc033gop.2 
ENSMUST00000199097.2 Gm42589 ENSMUST00000199097.2 Gm42589 (from geneSymbol) ENSMUST00000199097.1 uc291ahe.1 uc291ahe.2 uc291ahe.1 uc291ahe.2 
ENSMUST00000199099.2 Gm43661 ENSMUST00000199099.2 Gm43661 (from geneSymbol) ENSMUST00000199099.1 uc290zsw.1 uc290zsw.2 uc290zsw.1 uc290zsw.2 
ENSMUST00000199104.5 Enam ENSMUST00000199104.5 Enam (from geneSymbol) A0A0G2JEP7 A0A0G2JEP7_MOUSE ENSMUST00000199104.1 ENSMUST00000199104.2 ENSMUST00000199104.3 ENSMUST00000199104.4 Enam U82698 uc290wws.1 uc290wws.2 uc290wws.1 uc290wws.2 
ENSMUST00000199112.2 Trav15n-2 ENSMUST00000199112.2 Trav15n-2 (from geneSymbol) A0A0G2JGQ7 A0A0G2JGQ7_MOUSE ENSMUST00000199112.1 M37285 Trav15d-2-dv6d-2 Trav15n-2 uc288tzk.1 uc288tzk.2 immunoglobulin production extracellular space immune response uc288tzk.1 uc288tzk.2 
ENSMUST00000199117.2 Gm43610 ENSMUST00000199117.2 Gm43610 (from geneSymbol) ENSMUST00000199117.1 uc290twe.1 uc290twe.2 uc290twe.1 uc290twe.2 
ENSMUST00000199119.2 B230303O12Rik ENSMUST00000199119.2 B230303O12Rik (from geneSymbol) AK045684 ENSMUST00000199119.1 uc291bti.1 uc291bti.2 uc291bti.1 uc291bti.2 
ENSMUST00000199122.3 Gm35667 ENSMUST00000199122.3 Gm35667 (from geneSymbol) ENSMUST00000199122.1 ENSMUST00000199122.2 uc290jos.1 uc290jos.2 uc290jos.3 uc290jos.1 uc290jos.2 uc290jos.3 
ENSMUST00000199123.2 Gm43138 ENSMUST00000199123.2 Gm43138 (from geneSymbol) ENSMUST00000199123.1 uc290yef.1 uc290yef.2 uc290yef.1 uc290yef.2 
ENSMUST00000199137.2 Trav23 ENSMUST00000199137.2 Trav23 (from geneSymbol) A0A0G2JG17 A0A0G2JG17_MOUSE ENSMUST00000199137.1 Trav23 uc288ubp.1 uc288ubp.2 uc288ubp.1 uc288ubp.2 
ENSMUST00000199138.2 Gm43283 ENSMUST00000199138.2 Gm43283 (from geneSymbol) AK041063 ENSMUST00000199138.1 uc290jiv.1 uc290jiv.2 uc290jiv.1 uc290jiv.2 
ENSMUST00000199139.2 Gm42793 ENSMUST00000199139.2 Gm42793 (from geneSymbol) AK155231 ENSMUST00000199139.1 uc290xrc.1 uc290xrc.2 uc290xrc.1 uc290xrc.2 
ENSMUST00000199140.3 Mir5046 ENSMUST00000199140.3 microRNA 5046 (from RefSeq NR_039555.1) ENSMUST00000199140.1 ENSMUST00000199140.2 NR_039555 uc029tqw.1 uc029tqw.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029tqw.1 uc029tqw.2 
ENSMUST00000199142.5 Gm3409 ENSMUST00000199142.5 Gm3409 (from geneSymbol) A0A0G2JE67 A0A0G2JE67_MOUSE ENSMUST00000199142.1 ENSMUST00000199142.2 ENSMUST00000199142.3 ENSMUST00000199142.4 Gm3409 uc291bua.1 uc291bua.2 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc291bua.1 uc291bua.2 
ENSMUST00000199143.5 Igkv12-89 ENSMUST00000199143.5 Igkv12-89 (from geneSymbol) A0A0G2JGW8 A0A0G2JGW8_MOUSE ENSMUST00000199143.1 ENSMUST00000199143.2 ENSMUST00000199143.3 ENSMUST00000199143.4 Igkv12-89 uc291fjg.1 uc291fjg.2 immunoglobulin production extracellular space immune response uc291fjg.1 uc291fjg.2 
ENSMUST00000199149.2 Gm43118 ENSMUST00000199149.2 Gm43118 (from geneSymbol) ENSMUST00000199149.1 uc290yhv.1 uc290yhv.2 uc290yhv.1 uc290yhv.2 
ENSMUST00000199151.3 Mir7234 ENSMUST00000199151.3 microRNA 7234 (from RefSeq NR_106093.1) ENSMUST00000199151.1 ENSMUST00000199151.2 NR_106093 uc009hvl.1 uc009hvl.2 uc009hvl.3 uc009hvl.4 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc009hvl.1 uc009hvl.2 uc009hvl.3 uc009hvl.4 
ENSMUST00000199160.2 Igkv4-61 ENSMUST00000199160.2 Igkv4-61 (from geneSymbol) A0A0G2JH00 A0A0G2JH00_MOUSE BC038698 ENSMUST00000199160.1 Igkv4-61 uc291fla.1 uc291fla.2 immunoglobulin production extracellular space immune response uc291fla.1 uc291fla.2 
ENSMUST00000199164.2 Tsc22d2 ENSMUST00000199164.2 TSC22 domain family, member 2, transcript variant 2 (from RefSeq NM_001347233.1) A0A0G2JFZ4 A7LCN1 E9Q7M2 ENSMUST00000199164.1 NM_001347233 Q3V1I7 Q6PE86 T22D2_MOUSE Tsc22d2 uc008phq.1 uc008phq.2 uc008phq.3 uc008phq.4 Reduces the level of nuclear PKM isoform M2 which results in repression of cyclin CCND1 transcription and reduced cell growth. [Isoform TSC22D2-4]: May protect kidney cells from hyperosmotic stress. Interacts with NRBP1 (By similarity). Interacts with PKM isoform M2; the interaction results in reduced nuclear levels of PKM isoform M2, leading to repression of cyclin CCND1 transcription and reduced cell growth (By similarity). Interacts with WDR77 (By similarity). Event=Alternative splicing; Named isoforms=3; Comment=An additional isoform is suggested but there is no evidence of a translated protein that has an extended N-terminus and a truncated C-terminus. ; Name=TSC22D2-3 ; IsoId=E9Q7M2-1; Sequence=Displayed; Name=TSC22D2-1 ; IsoId=E9Q7M2-2; Sequence=VSP_061913; Name=TSC22D2-4 ; IsoId=E9Q7M2-3; Sequence=VSP_061912; Expressed in the cortex, medulla and papilla of the kidney. [Isoform TSC22D2-3]: Expressed in the kidney. [Isoform TSC22D2-4]: Expressed in the kidney. [Isoform TSC22D2-1]: Induced by renal hypertonic stress, via mRNA stabilization. [Isoform TSC22D2-3]: Induced by renal hypertonic stress, via mRNA stabilization. [Isoform TSC22D2-4]: Induced by renal hypertonic stress, via mRNA stabilization. Belongs to the TSC-22/Dip/Bun family. Sequence=BAE21164.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; transcription factor activity, sequence-specific DNA binding regulation of transcription, DNA-templated response to osmotic stress uc008phq.1 uc008phq.2 uc008phq.3 uc008phq.4 
ENSMUST00000199172.2 Gm42686 ENSMUST00000199172.2 Gm42686 (from geneSymbol) ENSMUST00000199172.1 uc290taa.1 uc290taa.2 uc290taa.1 uc290taa.2 
ENSMUST00000199177.2 Gm43625 ENSMUST00000199177.2 Gm43625 (from geneSymbol) ENSMUST00000199177.1 LF195296 uc291btk.1 uc291btk.2 uc291btk.1 uc291btk.2 
ENSMUST00000199187.2 Gm43254 ENSMUST00000199187.2 Gm43254 (from geneSymbol) ENSMUST00000199187.1 uc290juy.1 uc290juy.2 uc290juy.1 uc290juy.2 
ENSMUST00000199190.2 Gm42521 ENSMUST00000199190.2 Gm42521 (from geneSymbol) ENSMUST00000199190.1 LF194951 uc290vhg.1 uc290vhg.2 uc290vhg.1 uc290vhg.2 
ENSMUST00000199205.2 Gm38412 ENSMUST00000199205.2 predicted gene, 38412 (from RefSeq NR_177245.1) ENSMUST00000199205.1 NR_177245 uc290iio.1 uc290iio.2 uc290iio.1 uc290iio.2 
ENSMUST00000199219.2 5830437K03Rik ENSMUST00000199219.2 5830437K03Rik (from geneSymbol) AK017976 ENSMUST00000199219.1 uc290jsr.1 uc290jsr.2 uc290jsr.1 uc290jsr.2 
ENSMUST00000199221.2 Gm27680 ENSMUST00000199221.2 Gm27680 (from geneSymbol) AK039279 ENSMUST00000199221.1 uc012ebe.1 uc012ebe.2 uc012ebe.1 uc012ebe.2 
ENSMUST00000199224.4 Gm43353 ENSMUST00000199224.4 Gm43353 (from geneSymbol) AK149112 ENSMUST00000199224.1 ENSMUST00000199224.2 ENSMUST00000199224.3 uc290ylm.1 uc290ylm.2 uc290ylm.3 uc290ylm.4 uc290ylm.1 uc290ylm.2 uc290ylm.3 uc290ylm.4 
ENSMUST00000199228.2 Gm42971 ENSMUST00000199228.2 Gm42971 (from geneSymbol) ENSMUST00000199228.1 uc290jnb.1 uc290jnb.2 uc290jnb.1 uc290jnb.2 
ENSMUST00000199243.5 Srrt ENSMUST00000199243.5 serrate RNA effector molecule homolog (Arabidopsis), transcript variant 1 (from RefSeq NM_031405.2) Ars2 Asr2 ENSMUST00000199243.1 ENSMUST00000199243.2 ENSMUST00000199243.3 ENSMUST00000199243.4 NM_031405 Q3UD04 Q5D042 Q8VEE6 Q99MR4 Q99MR5 Q99MR6 Q99MR7 SRRT_MOUSE uc012eew.1 uc012eew.2 uc012eew.3 Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self- renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. Interacts with CASP8AP2 and ERBB4 (By similarity). Interacts with NCBP1/CBP80 and DROSHA (PubMed:19632182). Interacts with LUZP4 (By similarity). Interacts with NCBP2/CBP20 and NCBP3 (By similarity). Interacts with MTREX (By similarity). Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way. Event=Alternative splicing; Named isoforms=4; Name=A; IsoId=Q99MR6-1; Sequence=Displayed; Name=B; IsoId=Q99MR6-2; Sequence=VSP_000325; Name=C; IsoId=Q99MR6-3; Sequence=VSP_000325, VSP_000326; Name=D; IsoId=Q99MR6-4; Sequence=VSP_000326; Widely expressed, with a preference for proliferating cells. Highly expressed in hematopoietic tissues and reduced or absent expression in parenchymal organs like liver and kidney. In the brain, expressed in the subventricular zone by niche astrocytes, ependymal cells and neural stem cells. In this cerebral context, expressed in slowly dividing cells. Upon cell proliferation. Death around the time of implantation. Deletion in adults leads to proliferative arrest and bone marrow hypoplasia whereas parenchymal organs composed of nonproliferating cells are unaffected. Belongs to the ARS2 family. Sequence=AAH19117.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE29458.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleic acid binding DNA binding protein binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated mRNA processing cell proliferation gene silencing by RNA primary miRNA processing macromolecular complex positive regulation of neurogenesis neuronal stem cell population maintenance uc012eew.1 uc012eew.2 uc012eew.3 
ENSMUST00000199248.3 Mir9769 ENSMUST00000199248.3 microRNA 9769 (from RefSeq NR_128568.1) ENSMUST00000199248.1 ENSMUST00000199248.2 NR_128568 uc057agv.1 uc057agv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057agv.1 uc057agv.2 
ENSMUST00000199249.4 Gm42918 ENSMUST00000199249.4 Gm42918 (from geneSymbol) AK028074 ENSMUST00000199249.1 ENSMUST00000199249.2 ENSMUST00000199249.3 uc290zex.1 uc290zex.2 uc290zex.3 uc290zex.4 uc290zex.1 uc290zex.2 uc290zex.3 uc290zex.4 
ENSMUST00000199252.2 Gm42478 ENSMUST00000199252.2 Gm42478 (from geneSymbol) AK159047 ENSMUST00000199252.1 uc290vqo.1 uc290vqo.2 uc290vqo.1 uc290vqo.2 
ENSMUST00000199255.2 D530037P16Rik ENSMUST00000199255.2 D530037P16Rik (from geneSymbol) ENSMUST00000199255.1 uc290kiq.1 uc290kiq.2 uc290kiq.1 uc290kiq.2 
ENSMUST00000199259.3 Mir1949 ENSMUST00000199259.3 microRNA 1949 (from RefSeq NR_035472.1) ENSMUST00000199259.1 ENSMUST00000199259.2 NR_035472 uc012bbg.1 uc012bbg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610473.1 [ECO:0000345] ##Evidence-Data-END## uc012bbg.1 uc012bbg.2 
ENSMUST00000199266.2 Ighv8-12 ENSMUST00000199266.2 Ighv8-12 (from geneSymbol) A0A0G2JDE1 A0A0G2JDE1_MOUSE ENSMUST00000199266.1 Ighv8-12 MG386909 uc288kca.1 uc288kca.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kca.1 uc288kca.2 
ENSMUST00000199271.2 Gm30214 ENSMUST00000199271.2 predicted gene, 30214 (from RefSeq NR_155501.1) ENSMUST00000199271.1 NR_155501 uc288tyb.1 uc288tyb.2 uc288tyb.1 uc288tyb.2 
ENSMUST00000199273.2 Fam241a ENSMUST00000199273.2 family with sequence similarity 241, member A (from RefSeq NM_027482.3) ENSMUST00000199273.1 F241A_MOUSE NM_027482 Q9CZL2 uc008rhr.1 uc008rhr.2 uc008rhr.3 uc008rhr.4 Membrane ; Single-pass membrane protein Belongs to the FAM241 family. molecular_function Golgi apparatus biological_process membrane integral component of membrane intracellular membrane-bounded organelle uc008rhr.1 uc008rhr.2 uc008rhr.3 uc008rhr.4 
ENSMUST00000199275.2 Gm43789 ENSMUST00000199275.2 Gm43789 (from geneSymbol) AK081742 ENSMUST00000199275.1 uc290xpl.1 uc290xpl.2 uc290xpl.1 uc290xpl.2 
ENSMUST00000199279.2 Gm43684 ENSMUST00000199279.2 Gm43684 (from geneSymbol) ENSMUST00000199279.1 uc290zlx.1 uc290zlx.2 uc290zlx.1 uc290zlx.2 
ENSMUST00000199282.2 Gm42519 ENSMUST00000199282.2 Gm42519 (from geneSymbol) ENSMUST00000199282.1 M19114 uc290vgl.1 uc290vgl.2 uc290vgl.1 uc290vgl.2 
ENSMUST00000199285.2 Gm43327 ENSMUST00000199285.2 Gm43327 (from geneSymbol) ENSMUST00000199285.1 uc290jkr.1 uc290jkr.2 uc290jkr.1 uc290jkr.2 
ENSMUST00000199287.3 Mir3970 ENSMUST00000199287.3 microRNA 3970 (from RefSeq NR_039552.1) ENSMUST00000199287.1 ENSMUST00000199287.2 NR_039552 uc056zie.1 uc056zie.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zie.1 uc056zie.2 
ENSMUST00000199289.2 Gm43623 ENSMUST00000199289.2 Gm43623 (from geneSymbol) AK135176 ENSMUST00000199289.1 uc290svv.1 uc290svv.2 uc290svv.1 uc290svv.2 
ENSMUST00000199292.2 Gm43485 ENSMUST00000199292.2 Gm43485 (from geneSymbol) ENSMUST00000199292.1 uc290kxj.1 uc290kxj.2 uc290kxj.1 uc290kxj.2 
ENSMUST00000199295.5 Gm21655 ENSMUST00000199295.5 Gm21655 (from geneSymbol) ENSMUST00000199295.1 ENSMUST00000199295.2 ENSMUST00000199295.3 ENSMUST00000199295.4 uc290tus.1 uc290tus.2 uc290tus.1 uc290tus.2 
ENSMUST00000199296.2 Gm42725 ENSMUST00000199296.2 Gm42725 (from geneSymbol) ENSMUST00000199296.1 uc290vwp.1 uc290vwp.2 uc290vwp.1 uc290vwp.2 
ENSMUST00000199297.4 Or13l2 ENSMUST00000199297.4 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VET1) ENSMUST00000199297.1 ENSMUST00000199297.2 ENSMUST00000199297.3 Olfr1402 Or13l2 Q8VET1 Q8VET1_MOUSE uc290hxd.1 uc290hxd.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc290hxd.1 uc290hxd.2 
ENSMUST00000199304.2 Gm42555 ENSMUST00000199304.2 Gm42555 (from geneSymbol) BC043931 ENSMUST00000199304.1 uc290vec.1 uc290vec.2 uc290vec.1 uc290vec.2 
ENSMUST00000199309.5 4930431F12Rik ENSMUST00000199309.5 RIKEN cDNA 4930431F12 gene (from RefSeq NR_073013.1) ENSMUST00000199309.1 ENSMUST00000199309.2 ENSMUST00000199309.3 ENSMUST00000199309.4 NR_073013 uc033ijk.1 uc033ijk.2 uc033ijk.3 uc033ijk.1 uc033ijk.2 uc033ijk.3 
ENSMUST00000199317.2 Lamtor5 ENSMUST00000199317.2 As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. (from UniProt Q9D1L9) AK146289 ENSMUST00000199317.1 Hbxip LTOR5_MOUSE Q3UJV9 Q9D1L9 Xip uc290iof.1 uc290iof.2 As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Homodimer. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and RagD/RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator. Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1. Lysosome Cytoplasm, cytosol Belongs to the LAMTOR5 family. cytoplasm lysosome cytosol regulation of cell size viral genome replication positive regulation of TOR signaling negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein localization to lysosome cellular response to amino acid stimulus Ragulator complex positive regulation of TORC1 signaling guanyl-nucleotide exchange factor activity binding, bridging uc290iof.1 uc290iof.2 
ENSMUST00000199326.2 Gm9899 ENSMUST00000199326.2 predicted gene 9899 (from RefSeq NR_040427.1) ENSMUST00000199326.1 NR_040427 uc008wvq.1 uc008wvq.2 uc008wvq.3 uc008wvq.1 uc008wvq.2 uc008wvq.3 
ENSMUST00000199328.3 Mir327 ENSMUST00000199328.3 microRNA 327 (from RefSeq NR_030556.1) ENSMUST00000199328.1 ENSMUST00000199328.2 NR_030556 uc056ywg.1 uc056ywg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056ywg.1 uc056ywg.2 
ENSMUST00000199333.2 Gm42871 ENSMUST00000199333.2 Gm42871 (from geneSymbol) ENSMUST00000199333.1 uc291abl.1 uc291abl.2 uc291abl.1 uc291abl.2 
ENSMUST00000199336.2 Gm43378 ENSMUST00000199336.2 Gm43378 (from geneSymbol) BC062261 ENSMUST00000199336.1 uc291blg.1 uc291blg.2 uc291blg.1 uc291blg.2 
ENSMUST00000199347.3 Gm6260 ENSMUST00000199347.3 Gm6260 (from geneSymbol) AK043613 ENSMUST00000199347.1 ENSMUST00000199347.2 uc290kge.1 uc290kge.2 uc290kge.3 uc290kge.1 uc290kge.2 uc290kge.3 
ENSMUST00000199348.5 Platr30 ENSMUST00000199348.5 pluripotency associated transcript 30 (from RefSeq NR_152105.1) ENSMUST00000199348.1 ENSMUST00000199348.2 ENSMUST00000199348.3 ENSMUST00000199348.4 NR_152105 uc008qms.1 uc008qms.2 uc008qms.3 uc008qms.1 uc008qms.2 uc008qms.3 
ENSMUST00000199351.3 Mir3107 ENSMUST00000199351.3 microRNA 3107 (from RefSeq NR_037293.1) ENSMUST00000199351.1 ENSMUST00000199351.2 NR_037293 uc012gbj.1 uc012gbj.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610949.1 [ECO:0000345] ##Evidence-Data-END## uc012gbj.1 uc012gbj.2 
ENSMUST00000199354.2 Gm42748 ENSMUST00000199354.2 Gm42748 (from geneSymbol) ENSMUST00000199354.1 LF195155 uc290zja.1 uc290zja.2 uc290zja.1 uc290zja.2 
ENSMUST00000199355.2 Gm42870 ENSMUST00000199355.2 Gm42870 (from geneSymbol) ENSMUST00000199355.1 uc289dgy.1 uc289dgy.2 uc289dgy.1 uc289dgy.2 
ENSMUST00000199356.3 4930404A12Rik ENSMUST00000199356.3 4930404A12Rik (from geneSymbol) AK132795 ENSMUST00000199356.1 ENSMUST00000199356.2 uc029voq.1 uc029voq.2 uc029voq.3 uc029voq.1 uc029voq.2 uc029voq.3 
ENSMUST00000199363.2 Gm42953 ENSMUST00000199363.2 Gm42953 (from geneSymbol) ENSMUST00000199363.1 uc290zzu.1 uc290zzu.2 uc290zzu.1 uc290zzu.2 
ENSMUST00000199366.2 Gm42444 ENSMUST00000199366.2 Gm42444 (from geneSymbol) ENSMUST00000199366.1 uc290tgc.1 uc290tgc.2 uc290tgc.1 uc290tgc.2 
ENSMUST00000199373.2 Ighv1-78 ENSMUST00000199373.2 Ighv1-78 (from geneSymbol) A0A0G2JGN3 A0A0G2JGN3_MOUSE ENSMUST00000199373.1 Ighv1-78 S44583 uc288kcz.1 uc288kcz.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kcz.1 uc288kcz.2 
ENSMUST00000199375.2 Gm43585 ENSMUST00000199375.2 Gm43585 (from geneSymbol) ENSMUST00000199375.1 uc290ija.1 uc290ija.2 uc290ija.1 uc290ija.2 
ENSMUST00000199378.2 Gm42523 ENSMUST00000199378.2 Gm42523 (from geneSymbol) AK084079 ENSMUST00000199378.1 uc292lvc.1 uc292lvc.2 uc292lvc.1 uc292lvc.2 
ENSMUST00000199380.2 1700001N15Rik ENSMUST00000199380.2 1700001N15Rik (from geneSymbol) AK005614 ENSMUST00000199380.1 uc290kgd.1 uc290kgd.2 uc290kgd.1 uc290kgd.2 
ENSMUST00000199383.3 Mir3073b ENSMUST00000199383.3 microRNA 3073b (from RefSeq NR_049197.1) ENSMUST00000199383.1 ENSMUST00000199383.2 NR_049197 uc033gfr.1 uc033gfr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611593.1 [ECO:0000345] ##Evidence-Data-END## uc033gfr.1 uc033gfr.2 
ENSMUST00000199385.2 Gm43696 ENSMUST00000199385.2 Gm43696 (from geneSymbol) AK045034 ENSMUST00000199385.1 uc290iis.1 uc290iis.2 uc290iis.1 uc290iis.2 
ENSMUST00000199386.4 Gm19708 ENSMUST00000199386.4 Gm19708 (from geneSymbol) ENSMUST00000199386.1 ENSMUST00000199386.2 ENSMUST00000199386.3 uc290kba.1 uc290kba.2 uc290kba.3 uc290kba.4 uc290kba.1 uc290kba.2 uc290kba.3 uc290kba.4 
ENSMUST00000199389.2 Gm43532 ENSMUST00000199389.2 Gm43532 (from geneSymbol) ENSMUST00000199389.1 uc290wsm.1 uc290wsm.2 uc290wsm.1 uc290wsm.2 
ENSMUST00000199400.2 Gm43589 ENSMUST00000199400.2 Gm43589 (from geneSymbol) AK138390 ENSMUST00000199400.1 uc290fmp.1 uc290fmp.2 uc290fmp.1 uc290fmp.2 
ENSMUST00000199405.3 Mir3087 ENSMUST00000199405.3 microRNA 3087 (from RefSeq NR_037270.1) ENSMUST00000199405.1 ENSMUST00000199405.2 NR_037270 uc012bsb.1 uc012bsb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610928.1 [ECO:0000345] ##Evidence-Data-END## uc012bsb.1 uc012bsb.2 
ENSMUST00000199409.2 Gm43613 ENSMUST00000199409.2 Gm43613 (from geneSymbol) ENSMUST00000199409.1 LF194236 uc290kgb.1 uc290kgb.2 uc290kgb.1 uc290kgb.2 
ENSMUST00000199414.2 Gm43820 ENSMUST00000199414.2 Gm43820 (from geneSymbol) ENSMUST00000199414.1 uc290etn.1 uc290etn.2 uc290etn.1 uc290etn.2 
ENSMUST00000199417.2 Gm42664 ENSMUST00000199417.2 Gm42664 (from geneSymbol) ENSMUST00000199417.1 uc290jcu.1 uc290jcu.2 uc290jcu.1 uc290jcu.2 
ENSMUST00000199418.2 Gm43858 ENSMUST00000199418.2 Gm43858 (from geneSymbol) AK084100 ENSMUST00000199418.1 uc290kqi.1 uc290kqi.2 uc290kqi.1 uc290kqi.2 
ENSMUST00000199437.2 Igkv4-54 ENSMUST00000199437.2 Igkv4-54 (from geneSymbol) A0A0G2JES9 A0A0G2JES9_MOUSE DQ372760 ENSMUST00000199437.1 Igkv4-54 uc291fls.1 uc291fls.2 immunoglobulin production extracellular space immune response uc291fls.1 uc291fls.2 
ENSMUST00000199438.2 Gm43778 ENSMUST00000199438.2 Gm43778 (from geneSymbol) AK028014 ENSMUST00000199438.1 uc290vpn.1 uc290vpn.2 uc290vpn.1 uc290vpn.2 
ENSMUST00000199441.2 1110003F10Rik ENSMUST00000199441.2 1110003F10Rik (from geneSymbol) AK003351 ENSMUST00000199441.1 uc290vwa.1 uc290vwa.2 uc290vwa.1 uc290vwa.2 
ENSMUST00000199446.2 Gm42611 ENSMUST00000199446.2 Gm42611 (from geneSymbol) AB347917 ENSMUST00000199446.1 uc290kwc.1 uc290kwc.2 uc290kwc.1 uc290kwc.2 
ENSMUST00000199452.2 Traj49 ENSMUST00000199452.2 Traj49 (from geneSymbol) A0A0G2JEY2 A0A0G2JEY2_MOUSE ENSMUST00000199452.1 Traj49 uc288ucp.1 uc288ucp.2 uc288ucp.1 uc288ucp.2 
ENSMUST00000199459.2 Igkj5 ENSMUST00000199459.2 Igkj5 (from geneSymbol) A0A0G2JDI1 A0A0G2JDI1_MOUSE ENSMUST00000199459.1 Igkj5 M13413 uc291fpk.1 uc291fpk.2 uc291fpk.1 uc291fpk.2 
ENSMUST00000199463.2 Gm5565 ENSMUST00000199463.2 predicted gene 5565 (from RefSeq NM_001374726.1) A0A0G2JGB2 A0A0G2JGB2_MOUSE ENSMUST00000199463.1 Gm5565 NM_001374726 uc291btf.1 uc291btf.2 molecular_function guanyl-nucleotide exchange factor activity cellular_component biological_process uc291btf.1 uc291btf.2 
ENSMUST00000199465.2 Gm43307 ENSMUST00000199465.2 Gm43307 (from geneSymbol) ENSMUST00000199465.1 uc290kxx.1 uc290kxx.2 uc290kxx.1 uc290kxx.2 
ENSMUST00000199476.2 Gm43182 ENSMUST00000199476.2 Gm43182 (from geneSymbol) AK171588 ENSMUST00000199476.1 uc290vea.1 uc290vea.2 uc290vea.1 uc290vea.2 
ENSMUST00000199477.2 BC051076 ENSMUST00000199477.2 BC051076 (from geneSymbol) ENSMUST00000199477.1 uc290wwd.1 uc290wwd.2 uc290wwd.1 uc290wwd.2 
ENSMUST00000199480.2 Gm42889 ENSMUST00000199480.2 Gm42889 (from geneSymbol) ENSMUST00000199480.1 X57856 uc291ffq.1 uc291ffq.2 uc291ffq.1 uc291ffq.2 
ENSMUST00000199482.2 Gm42692 ENSMUST00000199482.2 Gm42692 (from geneSymbol) AK043872 ENSMUST00000199482.1 uc290enl.1 uc290enl.2 uc290enl.1 uc290enl.2 
ENSMUST00000199487.2 Igkj3 ENSMUST00000199487.2 Igkj3 (from geneSymbol) A0A0G2JGJ9 A0A0G2JGJ9_MOUSE ENSMUST00000199487.1 Igkj3 uc291fpi.1 uc291fpi.2 uc291fpi.1 uc291fpi.2 
ENSMUST00000199490.2 Iglj1 ENSMUST00000199490.2 Iglj1 (from geneSymbol) A0A0G2JE61 A0A0G2JE61_MOUSE ENSMUST00000199490.1 Iglj1 uc289dgm.1 uc289dgm.2 uc289dgm.1 uc289dgm.2 
ENSMUST00000199492.2 Gm43528 ENSMUST00000199492.2 Gm43528 (from geneSymbol) ENSMUST00000199492.1 uc290kuw.1 uc290kuw.2 uc290kuw.1 uc290kuw.2 
ENSMUST00000199494.3 Mir136 ENSMUST00000199494.3 microRNA 136 (from RefSeq NR_029550.1) ENSMUST00000199494.1 ENSMUST00000199494.2 NR_029550 uc011yso.1 uc011yso.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608244.1 [ECO:0000345] ##Evidence-Data-END## uc011yso.1 uc011yso.2 
ENSMUST00000199495.2 Gm43054 ENSMUST00000199495.2 Gm43054 (from geneSymbol) AK084942 ENSMUST00000199495.1 uc290toy.1 uc290toy.2 uc290toy.1 uc290toy.2 
ENSMUST00000199500.2 Gm43758 ENSMUST00000199500.2 Gm43758 (from geneSymbol) ENSMUST00000199500.1 uc290yjp.1 uc290yjp.2 uc290yjp.1 uc290yjp.2 
ENSMUST00000199504.2 Gm32754 ENSMUST00000199504.2 Gm32754 (from geneSymbol) AK076796 ENSMUST00000199504.1 uc008rnz.1 uc008rnz.2 uc008rnz.3 uc008rnz.1 uc008rnz.2 uc008rnz.3 
ENSMUST00000199507.3 Gm43242 ENSMUST00000199507.3 Gm43242 (from geneSymbol) ENSMUST00000199507.1 ENSMUST00000199507.2 uc290ide.1 uc290ide.2 uc290ide.3 uc290ide.1 uc290ide.2 uc290ide.3 
ENSMUST00000199510.5 Igkv14-100 ENSMUST00000199510.5 Igkv14-100 (from geneSymbol) A0A0G2JG36 A0A0G2JG36_MOUSE ENSMUST00000199510.1 ENSMUST00000199510.2 ENSMUST00000199510.3 ENSMUST00000199510.4 Igkv14-100 S72847 uc291fij.1 uc291fij.2 immunoglobulin production extracellular space immune response uc291fij.1 uc291fij.2 
ENSMUST00000199511.2 Gm42594 ENSMUST00000199511.2 Gm42594 (from geneSymbol) ENSMUST00000199511.1 uc290ebx.1 uc290ebx.2 uc290ebx.1 uc290ebx.2 
ENSMUST00000199512.3 Mir6962 ENSMUST00000199512.3 microRNA 6962 (from RefSeq NR_105927.1) ENSMUST00000199512.1 ENSMUST00000199512.2 NR_105927 uc033gww.1 uc033gww.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033gww.1 uc033gww.2 
ENSMUST00000199515.2 Gm42702 ENSMUST00000199515.2 Gm42702 (from geneSymbol) AK047159 ENSMUST00000199515.1 uc290iie.1 uc290iie.2 uc290iie.1 uc290iie.2 
ENSMUST00000199516.4 Gm44468 ENSMUST00000199516.4 Gm44468 (from geneSymbol) ENSMUST00000199516.1 ENSMUST00000199516.2 ENSMUST00000199516.3 uc287iqx.1 uc287iqx.2 uc287iqx.1 uc287iqx.2 
ENSMUST00000199517.2 C430019N01Rik ENSMUST00000199517.2 C430019N01Rik (from geneSymbol) AK049529 ENSMUST00000199517.1 uc290xiq.1 uc290xiq.2 uc290xiq.1 uc290xiq.2 
ENSMUST00000199524.3 Gm43607 ENSMUST00000199524.3 Gm43607 (from geneSymbol) ENSMUST00000199524.1 ENSMUST00000199524.2 uc290jeu.1 uc290jeu.2 uc290jeu.3 uc290jeu.1 uc290jeu.2 uc290jeu.3 
ENSMUST00000199525.3 Mir7015 ENSMUST00000199525.3 microRNA 7015 (from RefSeq NR_105982.1) ENSMUST00000199525.1 ENSMUST00000199525.2 NR_105982 uc033ieg.1 uc033ieg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ieg.1 uc033ieg.2 
ENSMUST00000199544.2 Gm43169 ENSMUST00000199544.2 Gm43169 (from geneSymbol) ENSMUST00000199544.1 uc290tnb.1 uc290tnb.2 uc290tnb.1 uc290tnb.2 
ENSMUST00000199545.3 Gm23370 ENSMUST00000199545.3 Gm23370 (from geneSymbol) ENSMUST00000199545.1 ENSMUST00000199545.2 uc287ljk.1 uc287ljk.2 uc287ljk.1 uc287ljk.2 
ENSMUST00000199549.4 Snord43 ENSMUST00000199549.4 Snord43 (from geneSymbol) AF357368 ENSMUST00000199549.1 ENSMUST00000199549.2 ENSMUST00000199549.3 uc011zwg.1 uc011zwg.2 uc011zwg.3 uc011zwg.4 uc011zwg.1 uc011zwg.2 uc011zwg.3 uc011zwg.4 
ENSMUST00000199551.2 A530030E21Rik ENSMUST00000199551.2 A530030E21Rik (from geneSymbol) AK080099 ENSMUST00000199551.1 uc289dha.1 uc289dha.2 uc289dha.1 uc289dha.2 
ENSMUST00000199552.2 6720482G16Rik ENSMUST00000199552.2 6720482G16Rik (from geneSymbol) ENSMUST00000199552.1 uc290flp.1 uc290flp.2 uc290flp.1 uc290flp.2 
ENSMUST00000199556.2 Gm42974 ENSMUST00000199556.2 Gm42974 (from geneSymbol) AK148613 ENSMUST00000199556.1 uc290jmw.1 uc290jmw.2 uc290jmw.1 uc290jmw.2 
ENSMUST00000199565.2 Gm42605 ENSMUST00000199565.2 Gm42605 (from geneSymbol) AK198190 ENSMUST00000199565.1 uc290xhl.1 uc290xhl.2 uc290xhl.1 uc290xhl.2 
ENSMUST00000199580.2 Gm43292 ENSMUST00000199580.2 Gm43292 (from geneSymbol) ENSMUST00000199580.1 uc291fpr.1 uc291fpr.2 uc291fpr.1 uc291fpr.2 
ENSMUST00000199589.2 Gm43066 ENSMUST00000199589.2 Gm43066 (from geneSymbol) AK029468 ENSMUST00000199589.1 uc290igh.1 uc290igh.2 uc290igh.1 uc290igh.2 
ENSMUST00000199592.5 Elp6 ENSMUST00000199592.5 elongator acetyltransferase complex subunit 6 (from RefSeq NM_001081381.1) ELP6_MOUSE ENSMUST00000199592.1 ENSMUST00000199592.2 ENSMUST00000199592.3 ENSMUST00000199592.4 NM_001081381 Q8BK75 Q9D0M9 Tmem103 uc009rtv.1 uc009rtv.2 uc009rtv.3 Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in cell migration (PubMed:22854966). tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Component of the elongator complex which consists of ELP1, ELP2, ELP3, ELP4, ELP5 and ELP6. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BK75-1; Sequence=Displayed; Name=2; IsoId=Q8BK75-2; Sequence=VSP_022723; Expressed throughout the cerebellum. Early embryonic lethality. Belongs to the ELP6 family. The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification. tRNA wobble uridine modification molecular_function nucleus cytosol positive regulation of cell migration Elongator holoenzyme complex uc009rtv.1 uc009rtv.2 uc009rtv.3 
ENSMUST00000199595.2 Gm42763 ENSMUST00000199595.2 Gm42763 (from geneSymbol) ENSMUST00000199595.1 uc292lqv.1 uc292lqv.2 uc292lqv.1 uc292lqv.2 
ENSMUST00000199604.2 Gm43826 ENSMUST00000199604.2 Gm43826 (from geneSymbol) ENSMUST00000199604.1 uc290ked.1 uc290ked.2 uc290ked.1 uc290ked.2 
ENSMUST00000199606.4 BC030343 ENSMUST00000199606.4 cDNA sequence BC030343 (from RefSeq NR_188747.1) ENSMUST00000199606.1 ENSMUST00000199606.2 ENSMUST00000199606.3 NR_188747 uc291bme.1 uc291bme.2 uc291bme.3 uc291bme.4 uc291bme.1 uc291bme.2 uc291bme.3 uc291bme.4 
ENSMUST00000199608.2 8430422M14Rik ENSMUST00000199608.2 8430422M14Rik (from geneSymbol) AK078814 ENSMUST00000199608.1 uc290eoy.1 uc290eoy.2 uc290eoy.1 uc290eoy.2 
ENSMUST00000199609.2 P2ry12 ENSMUST00000199609.2 purinergic receptor P2Y, G-protein coupled 12, transcript variant 2 (from RefSeq NM_001357007.1) ENSMUST00000199609.1 NM_001357007 P2Y12_MOUSE Q9CPV9 uc290fmm.1 uc290fmm.2 Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation. Cell membrane; Multi-pass membrane protein. The transmembrane domain is composed of seven transmembrane helices; most of these are not strictly perpendicular to the plane of the membrane, but are tilted and/or kinked. Agonist binding promotes a conformation change in the extracellular loops that leads to an inward movement of the transmembrane helices. Antagonists can bind to an overlapping site, but block the inward movement of the transmembrane helices (By similarity). Mice are viable and fertile, but display impaired blood coagulation, due to defects in platelet aggregation and thrombus formation. Belongs to the G-protein coupled receptor 1 family. G-protein coupled adenosine receptor activity ADP receptor activity adenosine receptor signaling pathway G-protein coupled receptor activity mitochondrion plasma membrane integral component of plasma membrane caveola substrate-dependent cell migration, cell extension signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway blood coagulation hemostasis glial cell migration external side of plasma membrane basal plasma membrane negative regulation of norepinephrine secretion membrane integral component of membrane calcium-mediated signaling cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration cell projection organization lamellipodium assembly platelet activation intrinsic component of membrane cell projection membrane positive regulation of integrin activation by cell surface receptor linked signal transduction positive regulation of cell adhesion mediated by integrin calcium-mediated signaling using extracellular calcium source G-protein coupled purinergic nucleotide receptor signaling pathway positive regulation of ion transport protein kinase B signaling cell body membrane G-protein coupled purinergic nucleotide receptor activity negative regulation of cell differentiation response to axon injury regulation of chemotaxis positive regulation of chemotaxis positive regulation of protein kinase B signaling regulation of calcium ion transport platelet aggregation calcium ion transmembrane transport cellular response to ATP cellular response to organic cyclic compound potassium ion transmembrane transport positive regulation of ruffle assembly regulation of microglial cell migration positive regulation of microglial cell migration uc290fmm.1 uc290fmm.2 
ENSMUST00000199610.2 Lmbr1 ENSMUST00000199610.2 Lmbr1 (from geneSymbol) ENSMUST00000199610.1 LF194880 uc290txd.1 uc290txd.2 uc290txd.1 uc290txd.2 
ENSMUST00000199616.2 4933428P19Rik ENSMUST00000199616.2 4933428P19Rik (from geneSymbol) AK196836 ENSMUST00000199616.1 uc287rqm.1 uc287rqm.2 uc287rqm.1 uc287rqm.2 
ENSMUST00000199618.3 Mir3084-1 ENSMUST00000199618.3 microRNA 3084-1 (from RefSeq NR_037245.1) ENSMUST00000199618.1 ENSMUST00000199618.2 NR_037245 uc012bog.1 uc012bog.2 uc012bog.3 uc012bog.4 uc012bog.5 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611659.1, LM610895.1 [ECO:0000345] ##Evidence-Data-END## uc012bog.1 uc012bog.2 uc012bog.3 uc012bog.4 uc012bog.5 
ENSMUST00000199621.3 Mir3074-2 ENSMUST00000199621.3 microRNA 3074-2 (from RefSeq NR_037294.1) ENSMUST00000199621.1 ENSMUST00000199621.2 NR_037294 uc012ghg.1 uc012ghg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610950.1 [ECO:0000345] ##Evidence-Data-END## uc012ghg.1 uc012ghg.2 
ENSMUST00000199630.2 Gm42819 ENSMUST00000199630.2 Gm42819 (from geneSymbol) ENSMUST00000199630.1 uc290hxy.1 uc290hxy.2 uc290hxy.1 uc290hxy.2 
ENSMUST00000199631.2 Gm15903 ENSMUST00000199631.2 Gm15903 (from geneSymbol) ENSMUST00000199631.1 uc291ade.1 uc291ade.2 uc291ade.1 uc291ade.2 
ENSMUST00000199632.2 4833413G10Rik ENSMUST00000199632.2 4833413G10Rik (from geneSymbol) ENSMUST00000199632.1 LF194831 uc290stk.1 uc290stk.2 uc290stk.1 uc290stk.2 
ENSMUST00000199637.2 Gm43697 ENSMUST00000199637.2 Gm43697 (from geneSymbol) ENSMUST00000199637.1 LF194205 uc290jpl.1 uc290jpl.2 uc290jpl.1 uc290jpl.2 
ENSMUST00000199642.2 Gm42520 ENSMUST00000199642.2 Gm42520 (from geneSymbol) ENSMUST00000199642.1 LF194952 uc290vhh.1 uc290vhh.2 uc290vhh.1 uc290vhh.2 
ENSMUST00000199644.2 Gm42778 ENSMUST00000199644.2 Gm42778 (from geneSymbol) ENSMUST00000199644.1 uc290yhj.1 uc290yhj.2 uc290yhj.1 uc290yhj.2 
ENSMUST00000199649.2 Gm43273 ENSMUST00000199649.2 Gm43273 (from geneSymbol) AK046915 ENSMUST00000199649.1 uc290xoh.1 uc290xoh.2 uc290xoh.1 uc290xoh.2 
ENSMUST00000199650.2 Gm43825 ENSMUST00000199650.2 Gm43825 (from geneSymbol) ENSMUST00000199650.1 uc290sti.1 uc290sti.2 uc290sti.1 uc290sti.2 
ENSMUST00000199653.2 Gm43176 ENSMUST00000199653.2 Gm43176 (from geneSymbol) ENSMUST00000199653.1 uc290vly.1 uc290vly.2 uc290vly.1 uc290vly.2 
ENSMUST00000199654.2 Gm43386 ENSMUST00000199654.2 Gm43386 (from geneSymbol) ENSMUST00000199654.1 uc290tyb.1 uc290tyb.2 uc290tyb.1 uc290tyb.2 
ENSMUST00000199657.2 Gm42770 ENSMUST00000199657.2 Gm42770 (from geneSymbol) ENSMUST00000199657.1 uc056zzr.1 uc056zzr.2 uc056zzr.1 uc056zzr.2 
ENSMUST00000199663.2 Gm43605 ENSMUST00000199663.2 Gm43605 (from geneSymbol) ENSMUST00000199663.1 uc290vls.1 uc290vls.2 uc290vls.1 uc290vls.2 
ENSMUST00000199664.3 Gm43267 ENSMUST00000199664.3 Gm43267 (from geneSymbol) ENSMUST00000199664.1 ENSMUST00000199664.2 uc291bpq.1 uc291bpq.2 uc291bpq.3 uc291bpq.1 uc291bpq.2 uc291bpq.3 
ENSMUST00000199671.3 Mir7094-1 ENSMUST00000199671.3 microRNA 7094-1 (from RefSeq NR_106062.1) ENSMUST00000199671.1 ENSMUST00000199671.2 NR_106062 uc033ggh.1 uc033ggh.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ggh.1 uc033ggh.2 
ENSMUST00000199673.6 Adh6b ENSMUST00000199673.6 alcohol dehydrogenase 6B (class V), transcript variant 4 (from RefSeq NM_001411493.1) A0A1D5RMB0 A0A1D5RMB0_MOUSE Adh6b ENSMUST00000199673.1 ENSMUST00000199673.2 ENSMUST00000199673.3 ENSMUST00000199673.4 ENSMUST00000199673.5 NM_001411493 uc290kbs.1 uc290kbs.2 Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Cytoplasm Belongs to the zinc-containing alcohol dehydrogenase family. alcohol dehydrogenase activity, zinc-dependent retinol dehydrogenase activity cytosol ethanol oxidation zinc ion binding oxidoreductase activity retinol metabolic process retinoic acid metabolic process metal ion binding oxidation-reduction process uc290kbs.1 uc290kbs.2 
ENSMUST00000199676.2 Gm42943 ENSMUST00000199676.2 Gm42943 (from geneSymbol) AK035799 ENSMUST00000199676.1 uc290kuv.1 uc290kuv.2 uc290kuv.1 uc290kuv.2 
ENSMUST00000199677.2 Gm43721 ENSMUST00000199677.2 Gm43721 (from geneSymbol) AK137787 ENSMUST00000199677.1 uc290vtf.1 uc290vtf.2 uc290vtf.1 uc290vtf.2 
ENSMUST00000199681.2 ENSMUSG00000121704 ENSMUST00000199681.2 ENSMUSG00000121704 (from geneSymbol) AK016844 ENSMUST00000199681.1 uc290fjg.1 uc290fjg.2 uc290fjg.1 uc290fjg.2 
ENSMUST00000199688.2 Gm42951 ENSMUST00000199688.2 Gm42951 (from geneSymbol) ENSMUST00000199688.1 uc290tng.1 uc290tng.2 uc290tng.1 uc290tng.2 
ENSMUST00000199697.3 Mir7092 ENSMUST00000199697.3 microRNA 7092 (from RefSeq NR_106060.1) ENSMUST00000199697.1 ENSMUST00000199697.2 NR_106060 uc033jqs.1 uc033jqs.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jqs.1 uc033jqs.2 
ENSMUST00000199706.2 Gm43330 ENSMUST00000199706.2 Gm43330 (from geneSymbol) ENSMUST00000199706.1 uc290ikz.1 uc290ikz.2 uc290ikz.1 uc290ikz.2 
ENSMUST00000199708.5 Grin2a ENSMUST00000199708.5 glutamate receptor, ionotropic, NMDA2A (epsilon 1) (from RefSeq NM_008170.4) ENSMUST00000199708.1 ENSMUST00000199708.2 ENSMUST00000199708.3 ENSMUST00000199708.4 NMDE1_MOUSE NM_008170 P35436 uc007ydc.1 uc007ydc.2 uc007ydc.3 Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium (PubMed:1374164). Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (By similarity). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:7816096, PubMed:8987814). Heterotetramer (By similarity). Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro) (PubMed:1374164). Can also form heterotetrameric channels that contain at least one zeta subunit (GRIN1), at least one epsilon subunit, plus GRIN3A or GRIN3B (PubMed:12008020). In vivo, the subunit composition may depend on the expression levels of the different subunits. Found in a complex with GRIN1, GRIN3A and PPP2CB (By similarity). Found in a complex with GRIN1 and GRIN3B (PubMed:12008020). Interacts with AIP1 (By similarity). Interacts with HIP1 and NETO1 (PubMed:17329427, PubMed:19243221). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (PubMed:23524343). Interacts with PDZ domains of PATJ and DLG4. Interacts with LRFN2 (By similarity). Interacts with RPH3A and DLG4; this ternary complex regulates NMDA receptor composition at postsynaptic membranes (By similarity). Interacts with SORCS2 (PubMed:28469074). Interacts with ARC; preventing ARC oligomerization (By similarity). P35436; Q62108: Dlg4; NbExp=15; IntAct=EBI-400115, EBI-300895; P35436; Q9D415: Dlgap1; NbExp=2; IntAct=EBI-400115, EBI-400152; P35436; Q63ZW7: Patj; NbExp=4; IntAct=EBI-400115, EBI-8366894; Cell projection, dendritic spine Cell membrane ; Multi-pass membrane protein Synapse Postsynaptic cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle membrane Note=Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex. Detected in striatum (PubMed:28469074). Detected in forbrain (PubMed:7816096). Detected in cerebellum (at protein level) (PubMed:8987814). Detected in brain cortex, piriform cortex, hippocampus, caudate-putamen, dentate gyrus and granule cell layer (PubMed:1374164, PubMed:7816096). Contains an N-terminal domain, a ligand-binding domain and a transmembrane domain. Agonist binding to the extracellular ligand- binding domains triggers channel gating. A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter. Mutant mice appear grossly normal and are fertile (PubMed:7816096, PubMed:8987814). NMDA channel currents are decreased in mutant brain slices. Contrary to wild-type, where tetanic stimulation leads to a strong long-term increase in synaptic strength, only modest long-term synaptic potentiation is seen in mutant mice (PubMed:7816096). Mossy fiber granule cells from mutant mice present a decrease of the slow component of the excitatory postsynaptic current (PubMed:8987814). The slow component of the excitatory postsynaptic current is nearly abolished in mossy fiber cells from mice lacking both Grin2a and Grin2c (PubMed:8987814). Mutant mice present subtle deficits in spatial learning (PubMed:7816096). Mice lacking both Grin2a and Grin2c display subtle motor deficits; they have no visible phenotype when performing simple tasks, but have decreased ability to walk across a narrow wooden bar, and are unable to stay on a rapidly rotating rod (PubMed:8987814). Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2A/GRIN2A subfamily. action potential startle response response to amphetamine ionotropic glutamate receptor activity NMDA glutamate receptor activity receptor binding ion channel activity cation channel activity calcium channel activity protein binding endoplasmic reticulum plasma membrane integral component of plasma membrane ion transport calcium ion transport chemical synaptic transmission learning or memory learning memory locomotory behavior synaptic vesicle glutamate receptor activity zinc ion binding visual learning response to wounding cell surface positive regulation of cell death postsynaptic density ligand-gated ion channel activity membrane integral component of membrane glutamate binding NMDA selective glutamate receptor complex sensory perception of pain calcium-mediated signaling protein kinase binding neurogenesis voltage-gated cation channel activity glutamate-gated calcium ion channel activity cell junction sleep cytoplasmic vesicle membrane cytoplasmic vesicle directional locomotion ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic glutamate receptor binding signaling receptor activity locomotion neurotransmitter binding negative regulation of protein catabolic process regulation of membrane potential dopamine metabolic process serotonin metabolic process response to drug presynaptic membrane cell projection neuron projection positive regulation of apoptotic process terminal bouton dendritic spine macromolecular complex binding synapse postsynaptic membrane response to ethanol metal ion binding protein heterodimerization activity protein dimerization activity regulation of synaptic plasticity regulation of long-term neuronal synaptic plasticity rhythmic process modulation of synaptic transmission cell adhesion molecule binding ATPase binding protein tetramerization regulation of postsynaptic membrane potential excitatory postsynaptic potential long-term synaptic potentiation cellular response to amino acid stimulus cellular response to zinc ion synaptic membrane dendritic spine organization scaffold protein binding calcium ion transmembrane import into cytosol postsynaptic density membrane glutamatergic synapse integral component of presynaptic membrane integral component of postsynaptic density membrane regulation of presynaptic membrane potential ligand-gated ion channel activity involved in regulation of presynaptic membrane potential protein localization to postsynaptic membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential extracellular-glutamate-gated ion channel activity detection of mechanical stimulus involved in sensory perception of pain uc007ydc.1 uc007ydc.2 uc007ydc.3 
ENSMUST00000199710.2 Gm43064 ENSMUST00000199710.2 Belongs to the adaptor complexes large subunit family. (from UniProt B0V3P3) Ap4b1 B0V3P3 B0V3P3_MOUSE BC031477 ENSMUST00000199710.1 Gm43064 uc290igz.1 uc290igz.2 Belongs to the adaptor complexes large subunit family. intracellular protein transport protein transport membrane vesicle-mediated transport membrane coat clathrin adaptor complex clathrin binding uc290igz.1 uc290igz.2 
ENSMUST00000199713.2 Gm43113 ENSMUST00000199713.2 Gm43113 (from geneSymbol) AK149151 ENSMUST00000199713.1 uc290svk.1 uc290svk.2 uc290svk.1 uc290svk.2 
ENSMUST00000199719.3 Mir691 ENSMUST00000199719.3 microRNA 691 (from RefSeq NR_030464.1) ENSMUST00000199719.1 ENSMUST00000199719.2 NR_030464 uc012ahc.1 uc012ahc.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012ahc.1 uc012ahc.2 
ENSMUST00000199729.2 Gm43776 ENSMUST00000199729.2 Gm43776 (from geneSymbol) ENSMUST00000199729.1 uc290tvl.1 uc290tvl.2 uc290tvl.1 uc290tvl.2 
ENSMUST00000199731.2 Gm25053 ENSMUST00000199731.2 Gm25053 (from geneSymbol) ENSMUST00000199731.1 uc290mwk.1 uc290mwk.2 uc290mwk.1 uc290mwk.2 
ENSMUST00000199733.2 Gm42706 ENSMUST00000199733.2 Gm42706 (from geneSymbol) BC032178 ENSMUST00000199733.1 uc290kgm.1 uc290kgm.2 uc290kgm.1 uc290kgm.2 
ENSMUST00000199734.2 6030400A10Rik ENSMUST00000199734.2 6030400A10Rik (from geneSymbol) AK020045 ENSMUST00000199734.1 uc290vdi.1 uc290vdi.2 uc290vdi.1 uc290vdi.2 
ENSMUST00000199745.3 Gm42750 ENSMUST00000199745.3 Gm42750 (from geneSymbol) ENSMUST00000199745.1 ENSMUST00000199745.2 uc290vgf.1 uc290vgf.2 uc290vgf.3 uc290vgf.1 uc290vgf.2 uc290vgf.3 
ENSMUST00000199746.5 Trav9d-2 ENSMUST00000199746.5 Trav9d-2 (from geneSymbol) A0A0G2JDP3 A0A0G2JDP3_MOUSE BC106771 ENSMUST00000199746.1 ENSMUST00000199746.2 ENSMUST00000199746.3 ENSMUST00000199746.4 Trav9d-2 Trav9n-2 uc288txg.1 uc288txg.2 uc288txg.1 uc288txg.2 
ENSMUST00000199747.2 Gm43376 ENSMUST00000199747.2 Gm43376 (from geneSymbol) AK084369 ENSMUST00000199747.1 uc290fjh.1 uc290fjh.2 uc290fjh.1 uc290fjh.2 
ENSMUST00000199751.2 4930459L07Rik ENSMUST00000199751.2 RIKEN cDNA 4930459L07 gene (from RefSeq NR_046190.1) ENSMUST00000199751.1 NR_046190 uc029vhs.1 uc029vhs.2 uc029vhs.3 uc029vhs.4 uc029vhs.1 uc029vhs.2 uc029vhs.3 uc029vhs.4 
ENSMUST00000199753.2 Trav7n-5 ENSMUST00000199753.2 Trav7n-5 (from geneSymbol) A0A075B604 A0A075B604_MOUSE ENSMUST00000199753.1 Trav7d-5 Trav7n-5 uc288tyo.1 uc288tyo.2 uc288tyo.1 uc288tyo.2 
ENSMUST00000199754.5 Gatad2b ENSMUST00000199754.5 GATA zinc finger domain containing 2B, transcript variant 2 (from RefSeq NM_139304.3) ENSMUST00000199754.1 ENSMUST00000199754.2 ENSMUST00000199754.3 ENSMUST00000199754.4 NM_139304 P66B_MOUSE Q8C9Q3 Q8VHR5 uc008qcb.1 uc008qcb.2 uc008qcb.3 Transcriptional repressor. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development. Homooligomer. Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5. The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes. Interacts with MBD2; this is required for the enhancement of MBD2-mediated repression and for targeting to the chromatin. Interacts with MBD3. Component of the MeCP1 histone deacetylase complex. Interacts with histone tails, including that of histones H2A, H2B, H3 and H4. Interacts with ERCC6. Q8VHR5; P12813: Nr4a1; NbExp=2; IntAct=EBI-3043880, EBI-10896863; Nucleus speckle Nucleus Chromosome Note=Speckled nuclear localization requires both CR1 and CR2 regions. Localizes to sites of DNA damage. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VHR5-1; Sequence=Displayed; Name=2; IsoId=Q8VHR5-2; Sequence=VSP_010930, VSP_010931; Both CR1 and CR2 regions are required for speckled nuclear localization. [Isoform 2]: May be due to intron retention. negative regulation of transcription from RNA polymerase II promoter protein binding nucleus nucleoplasm regulation of transcription, DNA-templated zinc ion binding NuRD complex nuclear speck sequence-specific DNA binding metal ion binding uc008qcb.1 uc008qcb.2 uc008qcb.3 
ENSMUST00000199761.2 Gm42455 ENSMUST00000199761.2 Gm42455 (from geneSymbol) ENSMUST00000199761.1 uc290tbx.1 uc290tbx.2 uc290tbx.1 uc290tbx.2 
ENSMUST00000199762.2 Gm43584 ENSMUST00000199762.2 Gm43584 (from geneSymbol) AY325122 ENSMUST00000199762.1 uc290ijg.1 uc290ijg.2 uc290ijg.1 uc290ijg.2 
ENSMUST00000199764.2 Gm19817 ENSMUST00000199764.2 Gm19817 (from geneSymbol) AK138075 ENSMUST00000199764.1 uc290fip.1 uc290fip.2 uc290fip.1 uc290fip.2 
ENSMUST00000199778.2 Gm42441 ENSMUST00000199778.2 Gm42441 (from geneSymbol) AK080643 ENSMUST00000199778.1 uc291ahm.1 uc291ahm.2 uc291ahm.1 uc291ahm.2 
ENSMUST00000199779.2 Gm43513 ENSMUST00000199779.2 Gm43513 (from geneSymbol) AK017468 ENSMUST00000199779.1 uc290xnv.1 uc290xnv.2 uc290xnv.1 uc290xnv.2 
ENSMUST00000199780.2 Gm43422 ENSMUST00000199780.2 Gm43422 (from geneSymbol) ENSMUST00000199780.1 uc290xvd.1 uc290xvd.2 uc290xvd.1 uc290xvd.2 
ENSMUST00000199783.2 Gm42446 ENSMUST00000199783.2 Gm42446 (from geneSymbol) AK133648 ENSMUST00000199783.1 uc290tfz.1 uc290tfz.2 uc290tfz.1 uc290tfz.2 
ENSMUST00000199788.2 Gm43756 ENSMUST00000199788.2 Gm43756 (from geneSymbol) AK046921 ENSMUST00000199788.1 uc290zyv.1 uc290zyv.2 uc290zyv.1 uc290zyv.2 
ENSMUST00000199790.2 Gm10652 ENSMUST00000199790.2 predicted gene 10652 (from RefSeq NR_189034.1) ENSMUST00000199790.1 NR_189034 uc290jdq.1 uc290jdq.2 uc290jdq.1 uc290jdq.2 
ENSMUST00000199792.2 Gm42640 ENSMUST00000199792.2 Gm42640 (from geneSymbol) ENSMUST00000199792.1 uc290vqq.1 uc290vqq.2 uc290vqq.1 uc290vqq.2 
ENSMUST00000199793.2 Gm42907 ENSMUST00000199793.2 Gm42907 (from geneSymbol) AK141756 ENSMUST00000199793.1 uc290zpk.1 uc290zpk.2 uc290zpk.1 uc290zpk.2 
ENSMUST00000199794.2 Gm43079 ENSMUST00000199794.2 Gm43079 (from geneSymbol) AK012773 ENSMUST00000199794.1 uc290epq.1 uc290epq.2 uc290epq.1 uc290epq.2 
ENSMUST00000199796.2 Gm43651 ENSMUST00000199796.2 Gm43651 (from geneSymbol) ENSMUST00000199796.1 uc290izm.1 uc290izm.2 uc290izm.1 uc290izm.2 
ENSMUST00000199799.2 Gm43604 ENSMUST00000199799.2 Gm43604 (from geneSymbol) BC053936 ENSMUST00000199799.1 uc291arq.1 uc291arq.2 uc291arq.1 uc291arq.2 
ENSMUST00000199800.2 Trav15d-2-dv6d-2 ENSMUST00000199800.2 Trav15d-2-dv6d-2 (from geneSymbol) A0A0G2JGQ7 A0A0G2JGQ7_MOUSE ENSMUST00000199800.1 M37285 Trav15d-2-dv6d-2 Trav15n-2 uc288txs.1 uc288txs.2 immunoglobulin production extracellular space immune response uc288txs.1 uc288txs.2 
ENSMUST00000199804.3 4930579F01Rik ENSMUST00000199804.3 4930579F01Rik (from geneSymbol) 4930579F01Rik A0A5F8MPV9 A0A5F8MPV9_MOUSE AK016318 ENSMUST00000199804.1 ENSMUST00000199804.2 uc290kbi.1 uc290kbi.2 uc290kbi.3 uc290kbi.1 uc290kbi.2 uc290kbi.3 
ENSMUST00000199806.2 Gm42841 ENSMUST00000199806.2 Gm42841 (from geneSymbol) AK136985 ENSMUST00000199806.1 uc290fjp.1 uc290fjp.2 uc290fjp.1 uc290fjp.2 
ENSMUST00000199820.2 Gm45354 ENSMUST00000199820.2 Gm45354 (from geneSymbol) ENSMUST00000199820.1 uc290hbu.1 uc290hbu.2 uc290hbu.1 uc290hbu.2 
ENSMUST00000199829.2 Gm43366 ENSMUST00000199829.2 Gm43366 (from geneSymbol) ENSMUST00000199829.1 uc290vhj.1 uc290vhj.2 uc290vhj.1 uc290vhj.2 
ENSMUST00000199842.3 Mir1291 ENSMUST00000199842.3 microRNA 1291 (from RefSeq NR_106171.1) ENSMUST00000199842.1 ENSMUST00000199842.2 NR_106171 uc289bbb.1 uc289bbb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc289bbb.1 uc289bbb.2 
ENSMUST00000199844.2 Gm42812 ENSMUST00000199844.2 Gm42812 (from geneSymbol) AK086005 ENSMUST00000199844.1 uc008pqp.1 uc008pqp.2 uc008pqp.3 uc008pqp.1 uc008pqp.2 uc008pqp.3 
ENSMUST00000199846.2 Gm42650 ENSMUST00000199846.2 RIKEN cDNA 6330410L21 gene (from RefSeq NR_040589.1) ENSMUST00000199846.1 NR_040589 uc008rik.1 uc008rik.2 uc008rik.3 uc008rik.1 uc008rik.2 uc008rik.3 
ENSMUST00000199847.2 Gm40332 ENSMUST00000199847.2 Gm40332 (from geneSymbol) AK042192 ENSMUST00000199847.1 uc291aca.1 uc291aca.2 uc291aca.1 uc291aca.2 
ENSMUST00000199851.2 Gm42651 ENSMUST00000199851.2 Gm42651 (from geneSymbol) ENSMUST00000199851.1 uc290zqu.1 uc290zqu.2 uc290zqu.1 uc290zqu.2 
ENSMUST00000199858.2 Gm42969 ENSMUST00000199858.2 Gm42969 (from geneSymbol) ENSMUST00000199858.1 uc290jnf.1 uc290jnf.2 uc290jnf.1 uc290jnf.2 
ENSMUST00000199859.2 Gm42696 ENSMUST00000199859.2 Gm42696 (from geneSymbol) ENSMUST00000199859.1 uc290ihx.1 uc290ihx.2 uc290ihx.1 uc290ihx.2 
ENSMUST00000199860.3 Mir219c ENSMUST00000199860.3 microRNA 219c (from RefSeq NR_106154.1) ENSMUST00000199860.1 ENSMUST00000199860.2 NR_106154 uc033hcu.1 uc033hcu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hcu.1 uc033hcu.2 
ENSMUST00000199867.2 1500005C15Rik ENSMUST00000199867.2 1500005C15Rik (from geneSymbol) AK005156 ENSMUST00000199867.1 uc290jnz.1 uc290jnz.2 uc290jnz.1 uc290jnz.2 
ENSMUST00000199871.2 Gm42541 ENSMUST00000199871.2 Gm42541 (from geneSymbol) AK135826 ENSMUST00000199871.1 uc290ksx.1 uc290ksx.2 uc290ksx.1 uc290ksx.2 
ENSMUST00000199877.2 A530083M17Rik ENSMUST00000199877.2 A530083M17Rik (from geneSymbol) AK041114 ENSMUST00000199877.1 uc290krj.1 uc290krj.2 uc290krj.1 uc290krj.2 
ENSMUST00000199879.2 Gm42983 ENSMUST00000199879.2 Gm42983 (from geneSymbol) AK079988 ENSMUST00000199879.1 uc290vfm.1 uc290vfm.2 uc290vfm.1 uc290vfm.2 
ENSMUST00000199891.2 Rtp3 ENSMUST00000199891.2 receptor transporter protein 3 (from RefSeq NM_153100.2) E9QP29 ENSMUST00000199891.1 NM_153100 Q2KHT1 Q5QGU6 Q8VDC2 RTP3_MOUSE Tmem7 uc057man.1 uc057man.2 uc057man.3 Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43. Interacts with TAS2R16. Membrane ; Single-pass type III membrane protein Expressed predominantly in the liver. Not detected in the olfactory epithelium. Belongs to the TMEM7 family. detection of chemical stimulus involved in sensory perception of bitter taste cytoplasm protein targeting to membrane membrane integral component of membrane olfactory receptor binding protein insertion into membrane uc057man.1 uc057man.2 uc057man.3 
ENSMUST00000199893.2 Gm42603 ENSMUST00000199893.2 Gm42603 (from geneSymbol) AK076467 ENSMUST00000199893.1 uc290xhs.1 uc290xhs.2 uc290xhs.1 uc290xhs.2 
ENSMUST00000199894.2 Fgfbp1 ENSMUST00000199894.2 fibroblast growth factor binding protein 1, transcript variant 4 (from RefSeq NM_001421577.1) ENSMUST00000199894.1 FGFP1_MOUSE NM_001421577 O70514 Q62399 uc033iji.1 uc033iji.2 uc033iji.3 Acts as a carrier protein that releases fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhances the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth (By similarity). Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF7, FGF10, FGF22 and HSPG2 (By similarity). Interacts with FGF2. Secreted, extracellular space Cell membrane ; Peripheral membrane protein Note=Extracellular and plasma membrane- associated. Expressed in intestine, ovary, lung, placenta and normal and wounded skin. Expressed in digestive system, skin, hair follicles, the dental germ, respiratory tract, various glandular tissues, kidney, liver and certain areas of the central nervous system between 8 and 16 dpc (at protein level). Expressed. in embryo between 9 to 18 dpc. Expressed at 14 dpc in the epithelial cells and 18 dpc in basal epithelial cells of intestinal crypts. Expressed in mesenchymal and epidermal structures of the body wall at 9 dpc. Expressed in basal cells of the subepidermal layer of the skin at 12 dpc. Expressed in hair follicles at 14 dpc. Expression is significantly up-regulated in skin papillomas and carcinomas. Belongs to the fibroblast growth factor-binding protein family. extracellular region extracellular space plasma membrane cell-cell signaling positive regulation of cell proliferation cell surface membrane fibroblast growth factor binding growth factor binding positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of cell migration involved in sprouting angiogenesis positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis uc033iji.1 uc033iji.2 uc033iji.3 
ENSMUST00000199896.2 Smarcc1 ENSMUST00000199896.2 Smarcc1 (from geneSymbol) ENSMUST00000199896.1 Q3UNN4 Q3UNN4_MOUSE Smarcc1 U85614 uc012hbg.1 uc012hbg.2 uc012hbg.3 DNA binding nucleus SWI/SNF complex ATP-dependent chromatin remodeling uc012hbg.1 uc012hbg.2 uc012hbg.3 
ENSMUST00000199897.3 Mir6976 ENSMUST00000199897.3 microRNA 6976 (from RefSeq NR_105942.1) ENSMUST00000199897.1 ENSMUST00000199897.2 NR_105942 uc033hef.1 uc033hef.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hef.1 uc033hef.2 
ENSMUST00000199898.3 Gm42500 ENSMUST00000199898.3 Gm42500 (from geneSymbol) ENSMUST00000199898.1 ENSMUST00000199898.2 uc291abb.1 uc291abb.2 uc291abb.3 uc291abb.1 uc291abb.2 uc291abb.3 
ENSMUST00000199907.3 Mir9-1 ENSMUST00000199907.3 microRNA 9-1 (from RefSeq NR_029817.1) ENSMUST00000199907.1 ENSMUST00000199907.2 NR_029817 uc012cro.1 uc012cro.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608647.1 [ECO:0000345] ##Evidence-Data-END## uc012cro.1 uc012cro.2 
ENSMUST00000199913.2 Gm42796 ENSMUST00000199913.2 Gm42796 (from geneSymbol) AK156990 ENSMUST00000199913.1 uc290wuk.1 uc290wuk.2 uc290wuk.1 uc290wuk.2 
ENSMUST00000199915.2 Gm43737 ENSMUST00000199915.2 Gm43737 (from geneSymbol) ENSMUST00000199915.1 LF193998 uc290guo.1 uc290guo.2 uc290guo.1 uc290guo.2 
ENSMUST00000199928.3 Snord3b-ps1 ENSMUST00000199928.3 Snord3b-ps1 (from geneSymbol) ENSMUST00000199928.1 ENSMUST00000199928.2 uc289pzv.1 uc289pzv.2 uc289pzv.1 uc289pzv.2 
ENSMUST00000199933.5 Ighv1-69 ENSMUST00000199933.5 Ighv1-69 (from geneSymbol) A0A0G2JFS5 A0A0G2JFS5_MOUSE ENSMUST00000199933.1 ENSMUST00000199933.2 ENSMUST00000199933.3 ENSMUST00000199933.4 EU885275 Ighv1-69 uc288kbz.1 uc288kbz.2 antigen binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288kbz.1 uc288kbz.2 
ENSMUST00000199936.2 Gm42515 ENSMUST00000199936.2 Gm42515 (from geneSymbol) ENSMUST00000199936.1 uc290jlj.1 uc290jlj.2 uc290jlj.1 uc290jlj.2 
ENSMUST00000199939.2 Gm43318 ENSMUST00000199939.2 Gm43318 (from geneSymbol) ENSMUST00000199939.1 uc290vkc.1 uc290vkc.2 uc290vkc.1 uc290vkc.2 
ENSMUST00000199942.5 Lgi2 ENSMUST00000199942.5 leucine-rich repeat LGI family, member 2, transcript variant 2 (from RefSeq NM_001310604.1) ENSMUST00000199942.1 ENSMUST00000199942.2 ENSMUST00000199942.3 ENSMUST00000199942.4 Kiaa1916 LGI2_MOUSE NM_001310604 Q80T76 Q8K4Z0 uc008xkn.1 uc008xkn.2 uc008xkn.3 uc008xkn.4 Required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K4Z0-1; Sequence=Displayed; Name=2; IsoId=Q8K4Z0-2; Sequence=VSP_007680, VSP_007681; Brain. Expressed in developing parvalbumin-positive basket cells. Sequence=BAC65852.1; Type=Erroneous initiation; Evidence=; molecular_function extracellular region extracellular space biological_process uc008xkn.1 uc008xkn.2 uc008xkn.3 uc008xkn.4 
ENSMUST00000199945.2 Gm42772 ENSMUST00000199945.2 Gm42772 (from geneSymbol) ENSMUST00000199945.1 uc290vkp.1 uc290vkp.2 uc290vkp.1 uc290vkp.2 
ENSMUST00000199951.2 Gm43570 ENSMUST00000199951.2 Gm43570 (from geneSymbol) AK051302 ENSMUST00000199951.1 uc056zso.1 uc056zso.2 uc056zso.3 uc056zso.1 uc056zso.2 uc056zso.3 
ENSMUST00000199953.2 Gm42869 ENSMUST00000199953.2 Gm42869 (from geneSymbol) ENSMUST00000199953.1 LF194105 uc290iaz.1 uc290iaz.2 uc290iaz.1 uc290iaz.2 
ENSMUST00000199972.2 Gm42508 ENSMUST00000199972.2 Gm42508 (from geneSymbol) ENSMUST00000199972.1 LF282939 uc290hxb.1 uc290hxb.2 uc290hxb.1 uc290hxb.2 
ENSMUST00000199973.3 Mir1191b ENSMUST00000199973.3 microRNA 1191b (from RefSeq NR_106141.1) ENSMUST00000199973.1 ENSMUST00000199973.2 NR_106141 uc033frn.1 uc033frn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033frn.1 uc033frn.2 
ENSMUST00000199975.2 Gm42613 ENSMUST00000199975.2 Gm42613 (from geneSymbol) ENSMUST00000199975.1 uc056zzu.1 uc056zzu.2 uc056zzu.3 uc056zzu.1 uc056zzu.2 uc056zzu.3 
ENSMUST00000199979.2 Gm43009 ENSMUST00000199979.2 Gm43009 (from geneSymbol) ENSMUST00000199979.1 uc290jlg.1 uc290jlg.2 uc290jlg.1 uc290jlg.2 
ENSMUST00000199981.2 Gm42498 ENSMUST00000199981.2 Gm42498 (from geneSymbol) AK042298 ENSMUST00000199981.1 uc291abg.1 uc291abg.2 uc291abg.1 uc291abg.2 
ENSMUST00000199984.3 Mir380 ENSMUST00000199984.3 microRNA 380 (from RefSeq NR_029881.1) ENSMUST00000199984.1 ENSMUST00000199984.2 NR_029881 uc011ytb.1 uc011ytb.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608715.1 [ECO:0000345] ##Evidence-Data-END## uc011ytb.1 uc011ytb.2 
ENSMUST00000199989.2 Gm43098 ENSMUST00000199989.2 Gm43098 (from geneSymbol) AK132995 ENSMUST00000199989.1 uc290fkm.1 uc290fkm.2 uc290fkm.1 uc290fkm.2 
ENSMUST00000199995.2 Gm43256 ENSMUST00000199995.2 Gm43256 (from geneSymbol) AK045322 ENSMUST00000199995.1 uc290iik.1 uc290iik.2 uc290iik.1 uc290iik.2 
ENSMUST00000199996.2 Gm43435 ENSMUST00000199996.2 Gm43435 (from geneSymbol) ENSMUST00000199996.1 uc290itf.1 uc290itf.2 uc290itf.1 uc290itf.2 
ENSMUST00000200000.2 5830411K02Rik ENSMUST00000200000.2 5830411K02Rik (from geneSymbol) ENSMUST00000200000.1 uc290xwi.1 uc290xwi.2 uc290xwi.1 uc290xwi.2 
ENSMUST00000200001.2 Gm43755 ENSMUST00000200001.2 Gm43755 (from geneSymbol) ENSMUST00000200001.1 uc290tzo.1 uc290tzo.2 uc290tzo.1 uc290tzo.2 
ENSMUST00000200006.3 1700113A16Rik ENSMUST00000200006.3 1700113A16Rik (from geneSymbol) AK008852 ENSMUST00000200006.1 ENSMUST00000200006.2 uc008pue.1 uc008pue.2 uc008pue.3 uc008pue.4 uc008pue.5 uc008pue.1 uc008pue.2 uc008pue.3 uc008pue.4 uc008pue.5 
ENSMUST00000200007.2 5430427N15Rik ENSMUST00000200007.2 5430427N15Rik (from geneSymbol) AK030680 ENSMUST00000200007.1 uc290xpt.1 uc290xpt.2 uc290xpt.1 uc290xpt.2 
ENSMUST00000200008.2 5330426L24Rik ENSMUST00000200008.2 5330426L24Rik (from geneSymbol) ENSMUST00000200008.1 uc288uez.1 uc288uez.2 uc288uez.1 uc288uez.2 
ENSMUST00000200016.2 Gm43311 ENSMUST00000200016.2 Gm43311 (from geneSymbol) AK136555 ENSMUST00000200016.1 uc290vwb.1 uc290vwb.2 uc290vwb.1 uc290vwb.2 
ENSMUST00000200017.2 Gm42765 ENSMUST00000200017.2 Gm42765 (from geneSymbol) AK035444 ENSMUST00000200017.1 uc008wvp.1 uc008wvp.2 uc008wvp.1 uc008wvp.2 
ENSMUST00000200022.2 Gm43041 ENSMUST00000200022.2 Gm43041 (from geneSymbol) ENSMUST00000200022.1 LF264241 uc290vrg.1 uc290vrg.2 uc290vrg.1 uc290vrg.2 
ENSMUST00000200026.2 Gm42872 ENSMUST00000200026.2 Gm42872 (from geneSymbol) ENSMUST00000200026.1 LF194215 uc290jug.1 uc290jug.2 uc290jug.1 uc290jug.2 
ENSMUST00000200030.3 Mir3544 ENSMUST00000200030.3 microRNA 3544 (from RefSeq NR_049184.1) ENSMUST00000200030.1 ENSMUST00000200030.2 NR_049184 uc033gfg.1 uc033gfg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611582.1 [ECO:0000345] ##Evidence-Data-END## uc033gfg.1 uc033gfg.2 
ENSMUST00000200032.2 Gm43339 ENSMUST00000200032.2 Gm43339 (from geneSymbol) AK036326 ENSMUST00000200032.1 uc290zuf.1 uc290zuf.2 uc290zuf.1 uc290zuf.2 
ENSMUST00000200033.2 Gm43503 ENSMUST00000200033.2 Gm43503 (from geneSymbol) AK142534 ENSMUST00000200033.1 uc290vgb.1 uc290vgb.2 uc290vgb.1 uc290vgb.2 
ENSMUST00000200044.2 Gm43421 ENSMUST00000200044.2 Gm43421 (from geneSymbol) AK035254 ENSMUST00000200044.1 uc290xuh.1 uc290xuh.2 uc290xuh.1 uc290xuh.2 
ENSMUST00000200046.2 Traj48 ENSMUST00000200046.2 Traj48 (from geneSymbol) A0A0G2JG88 A0A0G2JG88_MOUSE ENSMUST00000200046.1 S53013 Traj48 uc288ucq.1 uc288ucq.2 uc288ucq.1 uc288ucq.2 
ENSMUST00000200050.3 Mir7218 ENSMUST00000200050.3 microRNA 7218 (from RefSeq NR_106077.1) ENSMUST00000200050.1 ENSMUST00000200050.2 NR_106077 uc033hci.1 uc033hci.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hci.1 uc033hci.2 
ENSMUST00000200057.2 Gm42813 ENSMUST00000200057.2 Gm42813 (from geneSymbol) AK052782 ENSMUST00000200057.1 uc290ggt.1 uc290ggt.2 uc290ggt.1 uc290ggt.2 
ENSMUST00000200060.2 Gm43495 ENSMUST00000200060.2 Gm43495 (from geneSymbol) ENSMUST00000200060.1 uc291azr.1 uc291azr.2 uc291azr.1 uc291azr.2 
ENSMUST00000200067.2 Gm43571 ENSMUST00000200067.2 Gm43571 (from geneSymbol) ENSMUST00000200067.1 uc290zgw.1 uc290zgw.2 uc290zgw.1 uc290zgw.2 
ENSMUST00000200070.2 Gm43847 ENSMUST00000200070.2 Gm43847 (from geneSymbol) AK085231 ENSMUST00000200070.1 uc290ikp.1 uc290ikp.2 uc290ikp.1 uc290ikp.2 
ENSMUST00000200074.2 Iglj3p ENSMUST00000200074.2 Iglj3p (from geneSymbol) A0A0G2JFS3 A0A0G2JFS3_MOUSE ENSMUST00000200074.1 Iglj3p uc289dgo.1 uc289dgo.2 uc289dgo.1 uc289dgo.2 
ENSMUST00000200075.2 Gm43859 ENSMUST00000200075.2 Gm43859 (from geneSymbol) ENSMUST00000200075.1 LF194260 uc290kqh.1 uc290kqh.2 uc290kqh.1 uc290kqh.2 
ENSMUST00000200077.3 Gm42604 ENSMUST00000200077.3 Gm42604 (from geneSymbol) ENSMUST00000200077.1 ENSMUST00000200077.2 uc290xhp.1 uc290xhp.2 uc290xhp.3 uc290xhp.1 uc290xhp.2 uc290xhp.3 
ENSMUST00000200082.5 Mknk2 ENSMUST00000200082.5 MAP kinase-interacting serine/threonine kinase 2 (from RefSeq NM_021462.4) ENSMUST00000200082.1 ENSMUST00000200082.2 ENSMUST00000200082.3 ENSMUST00000200082.4 MKNK2_MOUSE Mnk2 NM_021462 O08606 Q75PY0 Q8CDB0 Q9D893 uc007gef.1 uc007gef.2 uc007gef.3 uc007gef.4 uc007gef.5 uc007gef.6 The protein encoded by this gene is a serine/threonine-protein kinase, which is targeted by both the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. This enzyme targets several substrates including eukaryotic translation initiation factor 4E and mammalian target of rapamycin, which are negatively regulated by its phosphorylation. Null mutant mice do not exhibit developmental or reproductive defects. However, mice null for both this protein and mitogen-activated protein kinase-interacting serine/threonine protein kinase 1 have delayed tumor development in phosphatase and tensin homolog mutant mice, indicating an oncogenic function for this gene in tumor development. [provided by RefSeq, Oct 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.64689.1, AK154235.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A- inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during spermatogenesis. Displays a high basal kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per monomer. ; Inhibited by CGP57380 and staurosporine. Interacts with ESR2 and EIF4E in the nucleus (By similarity). Monomer. Interacts with the C-terminal regions of EIF4G1 and EIF4G2; this interaction is promoted when MAPK pathways are repressed but repressed upon ERK proteins activation. Also binds to dephosphorylated MAPK3/ERK1 and MAPK1/ERK2. Interaction with phosphorylated MAPK3/ERK1 and MAPK1/ERK2 protects it from dephosphorylation and inactivation. Q8CDB0; P63085: Mapk1; NbExp=23; IntAct=EBI-646209, EBI-397697; Q8CDB0; P39429: Traf2; NbExp=3; IntAct=EBI-646209, EBI-520016; Cytoplasm Nucleus, PML body Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8CDB0-1; Sequence=Displayed; Name=2; IsoId=Q8CDB0-2; Sequence=VSP_007355; Ubiquitously expressed in all tissues examined, with high levels in skeletal muscle and low levels in brain. Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. Phosphorylated upon arsenic trioxide As(2)O(3) treatment. Phosphorylated by MAPK1/ERK2, MAPK11 and MAPK14 (By similarity). Dephosphorylated by PP2A. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Sequence=AAH10256.1; Type=Erroneous initiation; Evidence=; Sequence=BAB25570.2; Type=Frameshift; Evidence=; Sequence=CAA71966.1; Type=Frameshift; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity protein binding calmodulin binding ATP binding nucleus nucleoplasm cytoplasm regulation of translation protein phosphorylation apoptotic process calcium-dependent protein serine/threonine kinase activity kinase activity phosphorylation nuclear body PML body transferase activity peptidyl-serine phosphorylation hemopoiesis intracellular signal transduction protein autophosphorylation metal ion binding cellular response to arsenic-containing substance extrinsic apoptotic signaling pathway in absence of ligand uc007gef.1 uc007gef.2 uc007gef.3 uc007gef.4 uc007gef.5 uc007gef.6 
ENSMUST00000200084.2 Gm42820 ENSMUST00000200084.2 Gm42820 (from geneSymbol) AK037135 ENSMUST00000200084.1 uc290hxz.1 uc290hxz.2 uc290hxz.1 uc290hxz.2 
ENSMUST00000200085.3 Mir7650 ENSMUST00000200085.3 microRNA 7650 (from RefSeq NR_106108.1) ENSMUST00000200085.1 ENSMUST00000200085.2 NR_106108 uc033jiu.1 uc033jiu.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jiu.1 uc033jiu.2 
ENSMUST00000200088.2 Gm43719 ENSMUST00000200088.2 Gm43719 (from geneSymbol) AK137040 ENSMUST00000200088.1 uc290tfj.1 uc290tfj.2 uc290tfj.1 uc290tfj.2 
ENSMUST00000200089.2 Gm43047 ENSMUST00000200089.2 Gm43047 (from geneSymbol) ENSMUST00000200089.1 uc290vkj.1 uc290vkj.2 uc290vkj.1 uc290vkj.2 
ENSMUST00000200095.2 Gpr87 ENSMUST00000200095.2 G protein-coupled receptor 87 (from RefSeq NM_001302203.1) ENSMUST00000200095.1 GPR87_MOUSE NM_001302203 Q8C4Y7 Q99MT7 uc008pip.1 uc008pip.2 uc008pip.3 uc008pip.4 Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage (By similarity). Cell membrane ; Multi-pass membrane protein Expressed at high levels in testis and brain and to a lesser extent placenta, ovary, prostate, and skeletal muscle but not in heart, lung, kidney, liver or intestine. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity membrane integral component of membrane G-protein coupled purinergic nucleotide receptor signaling pathway G-protein coupled purinergic nucleotide receptor activity uc008pip.1 uc008pip.2 uc008pip.3 uc008pip.4 
ENSMUST00000200096.3 Mir28c ENSMUST00000200096.3 microRNA 28c (from RefSeq NR_039538.1) ENSMUST00000200096.1 ENSMUST00000200096.2 NR_039538 uc056yyr.1 uc056yyr.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056yyr.1 uc056yyr.2 
ENSMUST00000200101.2 Trav15-1-dv6-1 ENSMUST00000200101.2 Trav15-1-dv6-1 (from geneSymbol) ENSMUST00000200101.1 M38679 Q5R1D2 Q5R1D2_MOUSE TRADV15-1 Trav15-1-dv6-1 uc288uak.1 uc288uak.2 immunoglobulin production extracellular space immune response uc288uak.1 uc288uak.2 
ENSMUST00000200102.2 Gm42447 ENSMUST00000200102.2 Gm42447 (from geneSymbol) ENSMUST00000200102.1 uc290tga.1 uc290tga.2 uc290tga.1 uc290tga.2 
ENSMUST00000200104.2 Gm43341 ENSMUST00000200104.2 Gm43341 (from geneSymbol) AK138288 ENSMUST00000200104.1 uc290vkd.1 uc290vkd.2 uc290vkd.1 uc290vkd.2 
ENSMUST00000200108.2 Gm43428 ENSMUST00000200108.2 Gm43428 (from geneSymbol) AK142665 ENSMUST00000200108.1 uc290jyr.1 uc290jyr.2 uc290jyr.1 uc290jyr.2 
ENSMUST00000200110.2 Gm42598 ENSMUST00000200110.2 Gm42598 (from geneSymbol) AK039539 ENSMUST00000200110.1 uc290sxx.1 uc290sxx.2 uc290sxx.1 uc290sxx.2 
ENSMUST00000200115.2 Trav12-1 ENSMUST00000200115.2 Trav12-1 (from geneSymbol) A0N8R1 A0N8R1_MOUSE AK137945 ENSMUST00000200115.1 Trav12-1 uc288uah.1 uc288uah.2 immunoglobulin production extracellular space immune response uc288uah.1 uc288uah.2 
ENSMUST00000200120.2 Gm43329 ENSMUST00000200120.2 Gm43329 (from geneSymbol) ENSMUST00000200120.1 uc290iky.1 uc290iky.2 uc290iky.1 uc290iky.2 
ENSMUST00000200127.2 Trav7d-2 ENSMUST00000200127.2 Trav7d-2 (from geneSymbol) ENSMUST00000200127.1 Q5R1I3 Q5R1I3_MOUSE TRAV7D-2 Trav7-2 Trav7d-2 uc288twk.1 uc288twk.2 molecular_function cellular_component biological_process uc288twk.1 uc288twk.2 
ENSMUST00000200128.2 2610011E03Rik ENSMUST00000200128.2 2610011E03Rik (from geneSymbol) ENSMUST00000200128.1 uc291ahr.1 uc291ahr.2 uc291ahr.1 uc291ahr.2 
ENSMUST00000200129.3 Gm43645 ENSMUST00000200129.3 Gm43645 (from geneSymbol) ENSMUST00000200129.1 ENSMUST00000200129.2 uc291bbk.1 uc291bbk.2 uc291bbk.3 uc291bbk.1 uc291bbk.2 uc291bbk.3 
ENSMUST00000200130.2 Gm43203 ENSMUST00000200130.2 Gm43203 (from geneSymbol) ENSMUST00000200130.1 uc290eoi.1 uc290eoi.2 uc290eoi.1 uc290eoi.2 
ENSMUST00000200140.2 Gm43622 ENSMUST00000200140.2 Gm43622 (from geneSymbol) DQ564810 ENSMUST00000200140.1 uc029xgg.1 uc029xgg.2 uc029xgg.3 uc029xgg.1 uc029xgg.2 uc029xgg.3 
ENSMUST00000200146.2 Chil5 ENSMUST00000200146.2 chitinase-like 5 (from RefSeq NM_001080816.2) A0A0G2JDS2 A0A0G2JDS2_MOUSE Chil5 ENSMUST00000200146.1 NM_001080816 uc057bqo.1 uc057bqo.2 uc057bqo.3 chitinase activity extracellular region carbohydrate metabolic process chitin catabolic process chitin binding uc057bqo.1 uc057bqo.2 uc057bqo.3 
ENSMUST00000200155.2 Gm43558 ENSMUST00000200155.2 Gm43558 (from geneSymbol) AB033516 ENSMUST00000200155.1 uc290jwe.1 uc290jwe.2 uc290jwe.1 uc290jwe.2 
ENSMUST00000200156.5 Fbxw28 ENSMUST00000200156.5 Fbxw28 (from geneSymbol) A0A0G2JFZ2 A0A0G2JFZ2_MOUSE BC084592 ENSMUST00000200156.1 ENSMUST00000200156.2 ENSMUST00000200156.3 ENSMUST00000200156.4 Fbxw28 uc292lmi.1 uc292lmi.2 molecular_function cellular_component biological_process uc292lmi.1 uc292lmi.2 
ENSMUST00000200157.5 Ift22 ENSMUST00000200157.5 intraflagellar transport 22 (from RefSeq NM_026073.3) ENSMUST00000200157.1 ENSMUST00000200157.2 ENSMUST00000200157.3 ENSMUST00000200157.4 IFT22_MOUSE NM_026073 Q9DAI2 Rabl5 uc009abc.1 uc009abc.2 uc009abc.3 Small GTPase-like component of the intraflagellar transport (IFT) complex B. Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88. Cell projection, cilium Belongs to the small GTPase superfamily. Rab family. nucleotide binding GTPase activity GTP binding centrosome cilium intracellular protein transport intraciliary transport particle B Rab protein signal transduction intraciliary transport cell projection uc009abc.1 uc009abc.2 uc009abc.3 
ENSMUST00000200160.5 Igkv18-36 ENSMUST00000200160.5 Igkv18-36 (from geneSymbol) A0A0G2JEE1 A0A0G2JEE1_MOUSE ENSMUST00000200160.1 ENSMUST00000200160.2 ENSMUST00000200160.3 ENSMUST00000200160.4 Igkv18-36 uc291fmr.1 uc291fmr.2 immunoglobulin production extracellular space immune response uc291fmr.1 uc291fmr.2 
ENSMUST00000200169.6 Chd8 ENSMUST00000200169.6 chromodomain helicase DNA binding protein 8 (from RefSeq NM_201637.3) CHD8_MOUSE Chd8 ENSMUST00000200169.1 ENSMUST00000200169.2 ENSMUST00000200169.3 ENSMUST00000200169.4 ENSMUST00000200169.5 Kiaa1564 NM_201637 Q09XV5 Q3TV89 Q5I1Z2 Q6ZPM8 uc288ttq.1 uc288ttq.2 This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which is common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. In mammals, this gene has been shown to function in several processes including transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Knockout of this gene causes early embryonic lethality due to widespread apoptosis. Heterozygous loss of function mutations result in autism spectrum disorder-like behaviors that include increased anxiety, repetitive behavior, and altered social behavior. [provided by RefSeq, Dec 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: DQ190419.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co- transcriptional RNA processing likely via interaction with HNRNPL. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Interacts with CTNNB1 and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B (By similarity). Interacts with p53/TP53 and histone H1 (PubMed:19151705). Interacts with CTCF (PubMed:16949368). Interacts with TLK2 (By similarity). Interacts with HNRNPL in an RNA- dependent manner. Q09XV5; P28033: Cebpb; NbExp=2; IntAct=EBI-1169080, EBI-1029979; Q09XV5; Q61164: Ctcf; NbExp=3; IntAct=EBI-1169080, EBI-932785; Nucleus Note=Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q09XV5-1; Sequence=Displayed; Name=2; IsoId=Q09XV5-2; Sequence=VSP_036676, VSP_036677; Expressed predominantly from early- to mid-stage mouse embryogenesis. Detected throughout embryos from 7.5 to 9.5 dpc but localizes predominantly in the brain, faces, branchial arches, limb buds, and tail buds of embryos at 10.5 dpc. Sumoylated. Death during early embryogenesis due to widespread apoptosis. Embryos manifest growth retardation from 5.5 dpc and developmental arrest accompanied by massive apoptosis at 7.5 dpc. They develop into an egg cylinder but do not form a primitive streak or mesoderm. Mice lacking both Tp53 and Chd8 ameliorate this developmental arrest. Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily. Sequence=BAC98203.2; Type=Miscellaneous discrepancy; Note=Partially unspliced pre-RNA.; Evidence=; negative regulation of transcription from RNA polymerase II promoter nucleotide binding in utero embryonic development startle response p53 binding DNA binding DNA helicase activity chromatin binding helicase activity protein binding ATP binding nucleus nucleoplasm chromatin organization brain development long-term memory beta-catenin binding DNA-dependent ATPase activity regulation of gene expression Wnt signaling pathway hydrolase activity hydrolase activity, acting on acid anhydrides negative regulation of Wnt signaling pathway DNA duplex unwinding macromolecular complex methylated histone binding social behavior histone binding ATP-dependent chromatin remodeling negative regulation of apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase III promoter digestive tract development prepulse inhibition armadillo repeat domain binding MLL1 complex negative regulation of canonical Wnt signaling pathway negative regulation of fibroblast apoptotic process uc288ttq.1 uc288ttq.2 
ENSMUST00000200176.2 Gm42705 ENSMUST00000200176.2 Gm42705 (from geneSymbol) AK134227 ENSMUST00000200176.1 uc290kgl.1 uc290kgl.2 uc290kgl.1 uc290kgl.2 
ENSMUST00000200180.2 Gm43188 ENSMUST00000200180.2 Gm43188 (from geneSymbol) AK047834 ENSMUST00000200180.1 uc291aid.1 uc291aid.2 uc291aid.1 uc291aid.2 
ENSMUST00000200181.3 Gm23786 ENSMUST00000200181.3 Gm23786 (from geneSymbol) ENSMUST00000200181.1 ENSMUST00000200181.2 uc292rpj.1 uc292rpj.2 uc292rpj.1 uc292rpj.2 
ENSMUST00000200184.2 Gm42981 ENSMUST00000200184.2 Gm42981 (from geneSymbol) ENSMUST00000200184.1 uc290vfr.1 uc290vfr.2 uc290vfr.1 uc290vfr.2 
ENSMUST00000200187.3 Mir7042 ENSMUST00000200187.3 microRNA 7042 (from RefSeq NR_106009.1) ENSMUST00000200187.1 ENSMUST00000200187.2 NR_106009 uc033itz.1 uc033itz.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033itz.1 uc033itz.2 
ENSMUST00000200193.2 4930557B06Rik ENSMUST00000200193.2 4930557B06Rik (from geneSymbol) AK016157 ENSMUST00000200193.1 uc290yle.1 uc290yle.2 uc290yle.1 uc290yle.2 
ENSMUST00000200199.2 3830422I06Rik ENSMUST00000200199.2 3830422I06Rik (from geneSymbol) ENSMUST00000200199.1 LF193899 uc290eue.1 uc290eue.2 uc290eue.1 uc290eue.2 
ENSMUST00000200211.2 Iglj3 ENSMUST00000200211.2 Iglj3 (from geneSymbol) A0A0G2JDG5 A0A0G2JDG5_MOUSE ENSMUST00000200211.1 Iglj3 uc289dgp.1 uc289dgp.2 uc289dgp.1 uc289dgp.2 
ENSMUST00000200213.2 Gm45477 ENSMUST00000200213.2 Gm45477 (from geneSymbol) ENSMUST00000200213.1 LF251187 uc290hbt.1 uc290hbt.2 uc290hbt.1 uc290hbt.2 
ENSMUST00000200215.3 Mir7004 ENSMUST00000200215.3 microRNA 7004 (from RefSeq NR_105971.1) ENSMUST00000200215.1 ENSMUST00000200215.2 NR_105971 uc033hrn.1 uc033hrn.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hrn.1 uc033hrn.2 
ENSMUST00000200220.2 Gm42501 ENSMUST00000200220.2 Gm42501 (from geneSymbol) ENSMUST00000200220.1 uc291bml.1 uc291bml.2 uc291bml.1 uc291bml.2 
ENSMUST00000200221.2 Gm42607 ENSMUST00000200221.2 Gm42607 (from geneSymbol) AK047591 ENSMUST00000200221.1 uc290fiw.1 uc290fiw.2 uc290fiw.1 uc290fiw.2 
ENSMUST00000200225.3 Gm26379 ENSMUST00000200225.3 Gm26379 (from geneSymbol) ENSMUST00000200225.1 ENSMUST00000200225.2 uc290nim.1 uc290nim.2 uc290nim.1 uc290nim.2 
ENSMUST00000200230.3 Mir721 ENSMUST00000200230.3 microRNA 721 (from RefSeq NR_030500.1) ENSMUST00000200230.1 ENSMUST00000200230.2 NR_030500 uc012ees.1 uc012ees.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc012ees.1 uc012ees.2 
ENSMUST00000200233.2 Gm42766 ENSMUST00000200233.2 Gm42766 (from geneSymbol) AK043572 ENSMUST00000200233.1 uc290vkh.1 uc290vkh.2 uc290vkh.1 uc290vkh.2 
ENSMUST00000200234.3 Mir1843a ENSMUST00000200234.3 microRNA 1843a (from RefSeq NR_037207.1) ENSMUST00000200234.1 ENSMUST00000200234.2 NR_037207 uc011yoh.1 uc011yoh.2 uc011yoh.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc011yoh.1 uc011yoh.2 uc011yoh.3 
ENSMUST00000200235.2 Iglc3 ENSMUST00000200235.2 Iglc3 (from geneSymbol) A0A0G2JGQ8 A0A0G2JGQ8_MOUSE ENSMUST00000200235.1 Iglc3 uc289dgn.1 uc289dgn.2 uc289dgn.1 uc289dgn.2 
ENSMUST00000200244.2 8030487O14Rik ENSMUST00000200244.2 8030487O14Rik (from geneSymbol) AK020220 ENSMUST00000200244.1 uc290vfs.1 uc290vfs.2 uc290vfs.1 uc290vfs.2 
ENSMUST00000200252.3 Mir6964 ENSMUST00000200252.3 microRNA 6964 (from RefSeq NR_105929.1) ENSMUST00000200252.1 ENSMUST00000200252.2 NR_105929 uc033hah.1 uc033hah.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033hah.1 uc033hah.2 
ENSMUST00000200253.3 4930431L21Rik ENSMUST00000200253.3 4930431L21Rik (from geneSymbol) AK015276 ENSMUST00000200253.1 ENSMUST00000200253.2 uc290emc.1 uc290emc.2 uc290emc.3 uc290emc.1 uc290emc.2 uc290emc.3 
ENSMUST00000200255.2 B230334C09Rik ENSMUST00000200255.2 B230334C09Rik (from geneSymbol) ENSMUST00000200255.1 uc056zuy.1 uc056zuy.2 uc056zuy.3 uc056zuy.1 uc056zuy.2 uc056zuy.3 
ENSMUST00000200260.2 Gm43732 ENSMUST00000200260.2 Gm43732 (from geneSymbol) AK087734 ENSMUST00000200260.1 uc292loe.1 uc292loe.2 uc292loe.1 uc292loe.2 
ENSMUST00000200263.2 Gm43502 ENSMUST00000200263.2 Gm43502 (from geneSymbol) AK045426 ENSMUST00000200263.1 uc290tvm.1 uc290tvm.2 uc290tvm.1 uc290tvm.2 
ENSMUST00000200265.2 Gm43462 ENSMUST00000200265.2 Gm43462 (from geneSymbol) ENSMUST00000200265.1 LF194105 uc290iba.1 uc290iba.2 uc290iba.1 uc290iba.2 
ENSMUST00000200266.2 Gm42635 ENSMUST00000200266.2 Gm42635 (from geneSymbol) ENSMUST00000200266.1 uc290vqh.1 uc290vqh.2 uc290vqh.1 uc290vqh.2 
ENSMUST00000200267.2 Fam220a ENSMUST00000200267.2 family with sequence similarity 220, member A, transcript variant 2 (from RefSeq NM_133703.5) Acpin1 B2RVG9 ENSMUST00000200267.1 F220A_MOUSE NM_133703 Q3ZN08 Q8BPE1 Q99JV7 Q9D5Z1 Sipar uc291bno.1 uc291bno.2 May negatively regulate STAT3. Interacts with STAT3. Nucleus Sequence=AAH05638.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; negative regulation of transcription from RNA polymerase II promoter protein binding nucleus protein dephosphorylation positive regulation of protein binding STAT family protein binding uc291bno.1 uc291bno.2 
ENSMUST00000200275.2 Gm43751 ENSMUST00000200275.2 Gm43751 (from geneSymbol) ENSMUST00000200275.1 uc290jms.1 uc290jms.2 uc290jms.1 uc290jms.2 
ENSMUST00000200282.2 4930502C17Rik ENSMUST00000200282.2 4930502C17Rik (from geneSymbol) ENSMUST00000200282.1 uc290eme.1 uc290eme.2 uc290eme.1 uc290eme.2 
ENSMUST00000200283.2 Gm43072 ENSMUST00000200283.2 Gm43072 (from geneSymbol) AK142776 ENSMUST00000200283.1 uc290jpz.1 uc290jpz.2 uc290jpz.1 uc290jpz.2 
ENSMUST00000200285.2 Gm43822 ENSMUST00000200285.2 Gm43822 (from geneSymbol) ENSMUST00000200285.1 uc290esd.1 uc290esd.2 uc290esd.1 uc290esd.2 
ENSMUST00000200288.2 Gm42602 ENSMUST00000200288.2 Gm42602 (from geneSymbol) ENSMUST00000200288.1 uc290xia.1 uc290xia.2 uc290xia.1 uc290xia.2 
ENSMUST00000200298.2 Pitpnb ENSMUST00000200298.2 phosphatidylinositol transfer protein, beta, transcript variant 7 (from RefSeq NM_001359217.1) ENSMUST00000200298.1 NM_001359217 Pitpnb Q8JZZ5 Q8JZZ5_MOUSE uc008ysc.1 uc008ysc.2 uc008ysc.3 uc008ysc.4 This gene encodes a member of the phosphatidylinositol transfer protein family. The encoded protein catalyzes the transfer of phospholipids (phosphatidylinositol and phosphatidylcholine) between membranes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out); Xref=Rhea:RHEA:38691, ChEBI:CHEBI:57880; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38692; Evidence=; Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38572; Evidence=; Reaction=an N-(acyl)-sphingosylphosphocholine(in) = an N-(acyl)- sphingosylphosphocholine(out); Xref=Rhea:RHEA:43776, ChEBI:CHEBI:64583; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43777; Evidence=; Endoplasmic reticulum membrane Golgi apparatus membrane Belongs to the PtdIns transfer protein family. PI transfer class I subfamily. phospholipid transporter activity phosphatidylcholine transporter activity phosphatidylinositol transporter activity phospholipid transport phosphatidylcholine binding phosphatidylinositol binding uc008ysc.1 uc008ysc.2 uc008ysc.3 uc008ysc.4 
ENSMUST00000200303.2 Gm42840 ENSMUST00000200303.2 Gm42840 (from geneSymbol) AK140291 ENSMUST00000200303.1 uc290fjm.1 uc290fjm.2 uc290fjm.1 uc290fjm.2 
ENSMUST00000200304.3 Mir7217 ENSMUST00000200304.3 microRNA 7217 (from RefSeq NR_106076.1) ENSMUST00000200304.1 ENSMUST00000200304.2 NR_106076 uc029tft.1 uc029tft.2 uc029tft.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc029tft.1 uc029tft.2 uc029tft.3 
ENSMUST00000200310.2 Gm43002 ENSMUST00000200310.2 Gm43002 (from geneSymbol) ENSMUST00000200310.1 uc290vqb.1 uc290vqb.2 uc290vqb.1 uc290vqb.2 
ENSMUST00000200312.2 Gm43258 ENSMUST00000200312.2 Gm43258 (from geneSymbol) AK042078 ENSMUST00000200312.1 uc290iig.1 uc290iig.2 uc290iig.1 uc290iig.2 
ENSMUST00000200317.5 Zfp804b ENSMUST00000200317.5 zinc finger protein 804B (from RefSeq NM_001163223.1) A0A0G2JGH6 A0A0G2JGH6_MOUSE ENSMUST00000200317.1 ENSMUST00000200317.2 ENSMUST00000200317.3 ENSMUST00000200317.4 NM_001163223 Zfp804b uc012dry.1 uc012dry.2 uc012dry.3 molecular_function nucleic acid binding biological_process metal ion binding uc012dry.1 uc012dry.2 uc012dry.3 
ENSMUST00000200319.2 Gm42540 ENSMUST00000200319.2 Gm42540 (from geneSymbol) AK157165 ENSMUST00000200319.1 uc290ksz.1 uc290ksz.2 uc290ksz.1 uc290ksz.2 
ENSMUST00000200320.2 Gm19710 ENSMUST00000200320.2 Gm19710 (from geneSymbol) ENSMUST00000200320.1 uc290gze.1 uc290gze.2 uc290gze.1 uc290gze.2 
ENSMUST00000200327.2 Gm30484 ENSMUST00000200327.2 Gm30484 (from geneSymbol) ENSMUST00000200327.1 uc290jvt.1 uc290jvt.2 uc290jvt.1 uc290jvt.2 
ENSMUST00000200329.2 Asb17os ENSMUST00000200329.2 Asb17os (from geneSymbol) ENSMUST00000200329.1 uc290kru.1 uc290kru.2 uc290kru.1 uc290kru.2 
ENSMUST00000200331.2 Gm43487 ENSMUST00000200331.2 Gm43487 (from geneSymbol) ENSMUST00000200331.1 uc290kxn.1 uc290kxn.2 uc290kxn.1 uc290kxn.2 
ENSMUST00000200336.2 Gm43657 ENSMUST00000200336.2 Gm43657 (from geneSymbol) ENSMUST00000200336.1 LF194856 uc290tmg.1 uc290tmg.2 uc290tmg.1 uc290tmg.2 
ENSMUST00000200343.2 Gm43857 ENSMUST00000200343.2 Gm43857 (from geneSymbol) AK042458 ENSMUST00000200343.1 uc290kqj.1 uc290kqj.2 uc290kqj.1 uc290kqj.2 
ENSMUST00000200346.3 Gm22813 ENSMUST00000200346.3 Gm22813 (from geneSymbol) ENSMUST00000200346.1 ENSMUST00000200346.2 uc289zbr.1 uc289zbr.2 uc289zbr.1 uc289zbr.2 
ENSMUST00000200347.2 Gm42941 ENSMUST00000200347.2 Gm42941 (from geneSymbol) ENSMUST00000200347.1 LF194110 uc290ich.1 uc290ich.2 uc290ich.1 uc290ich.2 
ENSMUST00000200349.2 Gm42449 ENSMUST00000200349.2 Gm42449 (from geneSymbol) AK037608 ENSMUST00000200349.1 uc290jta.1 uc290jta.2 uc290jta.1 uc290jta.2 
ENSMUST00000200359.2 Gm43290 ENSMUST00000200359.2 Gm43290 (from geneSymbol) ENSMUST00000200359.1 uc290vwn.1 uc290vwn.2 uc290vwn.1 uc290vwn.2 
ENSMUST00000200361.2 Gm42940 ENSMUST00000200361.2 Gm42940 (from geneSymbol) ENSMUST00000200361.1 uc290izo.1 uc290izo.2 uc290izo.1 uc290izo.2 
ENSMUST00000200367.2 Gm43465 ENSMUST00000200367.2 Gm43465 (from geneSymbol) AK076375 ENSMUST00000200367.1 uc290ibq.1 uc290ibq.2 uc290ibq.1 uc290ibq.2 
ENSMUST00000200369.2 Gm42486 ENSMUST00000200369.2 Gm42486 (from geneSymbol) ENSMUST00000200369.1 uc290vqu.1 uc290vqu.2 uc290vqu.1 uc290vqu.2 
ENSMUST00000200370.2 Gm42898 ENSMUST00000200370.2 Gm42898 (from geneSymbol) ENSMUST00000200370.1 uc290ffc.1 uc290ffc.2 uc290ffc.1 uc290ffc.2 
ENSMUST00000200372.2 1110060G06Rik ENSMUST00000200372.2 1110060G06Rik (from geneSymbol) AK004326 ENSMUST00000200372.1 uc290tja.1 uc290tja.2 uc290tja.1 uc290tja.2 
ENSMUST00000200375.2 9230114J08Rik ENSMUST00000200375.2 9230114J08Rik (from geneSymbol) AK020347 ENSMUST00000200375.1 uc290hwh.1 uc290hwh.2 uc290hwh.1 uc290hwh.2 
ENSMUST00000200378.2 Gm42685 ENSMUST00000200378.2 Gm42685 (from geneSymbol) AK139217 ENSMUST00000200378.1 uc290szx.1 uc290szx.2 uc290szx.1 uc290szx.2 
ENSMUST00000200383.3 Mir7215 ENSMUST00000200383.3 microRNA 7215 (from RefSeq NR_106074.1) ENSMUST00000200383.1 ENSMUST00000200383.2 NR_106074 uc033fpv.1 uc033fpv.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033fpv.1 uc033fpv.2 
ENSMUST00000200385.2 Gm43200 ENSMUST00000200385.2 Gm43200 (from geneSymbol) ENSMUST00000200385.1 uc290vhw.1 uc290vhw.2 uc290vhw.1 uc290vhw.2 
ENSMUST00000200389.2 Pde5a ENSMUST00000200389.2 phosphodiesterase 5A, cGMP-specific, transcript variant 2 (from RefSeq NM_001409793.1) A0A0G2JF67 A0A0G2JF67_MOUSE ENSMUST00000200389.1 NM_001409793 Pde5a uc290jho.1 uc290jho.2 Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, ChEBI:CHEBI:58115; EC=3.1.4.35; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16958; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1. Belongs to the cyclic nucleotide phosphodiesterase family. 3',5'-cyclic-nucleotide phosphodiesterase activity signal transduction phosphoric diester hydrolase activity hydrolase activity metal ion binding uc290jho.1 uc290jho.2 
ENSMUST00000200393.5 Ints1 ENSMUST00000200393.5 integrator complex subunit 1 (from RefSeq NM_026748.3) ENSMUST00000200393.1 ENSMUST00000200393.2 ENSMUST00000200393.3 ENSMUST00000200393.4 INT1_MOUSE NM_026748 Q0KK58 Q6P4S8 Q80UQ7 Q91Z01 Q9CTF7 uc033ini.1 uc033ini.2 uc033ini.3 Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (By similarity). Interacts with ESRRB, ESRRB is probably not a core component of the multiprotein complex Integrator and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (PubMed:26206133). Nucleus membrane ; Single-pass membrane protein Sequence=AAH63266.1; Type=Miscellaneous discrepancy; Note=Could be due to alternative splicing but with non canonical splice junction.; Evidence=; Sequence=BAF03197.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; blastocyst growth inner cell mass cell proliferation molecular_function nucleus membrane integral component of membrane snRNA processing nuclear membrane integrator complex U2 snRNA 3'-end processing negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process uc033ini.1 uc033ini.2 uc033ini.3 
ENSMUST00000200395.2 E030026E10Rik ENSMUST00000200395.2 E030026E10Rik (from geneSymbol) AK043829 ENSMUST00000200395.1 uc290vgd.1 uc290vgd.2 uc290vgd.1 uc290vgd.2 
ENSMUST00000200397.5 St6galnac3 ENSMUST00000200397.5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, transcript variant 4 (from RefSeq NR_184541.1) ENSMUST00000200397.1 ENSMUST00000200397.2 ENSMUST00000200397.3 ENSMUST00000200397.4 NR_184541 Q9JHP5 Q9WUV2 SIA7C_MOUSE Siat7c uc008rtw.1 uc008rtw.2 uc008rtw.3 Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal- beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:10207017, PubMed:10601645). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (By similarity). Reaction=an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal- (1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+); Xref=Rhea:RHEA:53896, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:146021, ChEBI:CHEBI:149714; EC=2.4.3.7; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53897; Evidence=; Reaction=a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41968, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568, ChEBI:CHEBI:78569; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41969; Evidence=; Reaction=a globoside MSGG + CMP-N-acetyl-beta-neuraminate = a globoside DSGG + CMP + H(+); Xref=Rhea:RHEA:56088, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:140623, ChEBI:CHEBI:140624; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56089; Evidence=; Reaction=3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L- Ser-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac- (2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser- [protein] + CMP + H(+); Xref=Rhea:RHEA:65280, Rhea:RHEA-COMP:16760, Rhea:RHEA-COMP:16761, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:156395, ChEBI:CHEBI:156397; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65281; Evidence=; Reaction=3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L- Thr-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac- (2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr- [protein] + CMP + H(+); Xref=Rhea:RHEA:65284, Rhea:RHEA-COMP:16762, Rhea:RHEA-COMP:16763, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:156396, ChEBI:CHEBI:156398; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65285; Evidence=; Protein modification; protein glycosylation. Glycolipid biosynthesis. Golgi apparatus membrane ; Single- pass type II membrane protein In adult tissues, high expression in brain, lung and heart and to a lesser extent in kidney, mammary gland, spleen, testis and thymus. In brain, expression reaches maximum levels at day 12 of the embryonic stage. Keeps almost similar levels during mouse development. Belongs to the glycosyltransferase 29 family. Name=Functional Glycomics Gateway - GTase; Note=ST6GalNAc III; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_652"; Golgi membrane ganglioside biosynthetic process alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity nucleoplasm Golgi apparatus protein glycosylation glycosylceramide metabolic process glycosphingolipid metabolic process sialyltransferase activity glycoprotein metabolic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity sialylation uc008rtw.1 uc008rtw.2 uc008rtw.3 
ENSMUST00000200401.2 Crybg1 ENSMUST00000200401.2 crystallin beta-gamma domain containing 1, transcript variant 1 (from RefSeq NM_001368305.1) A0A0G2JG52 A0A0G2JG52_MOUSE Aim1 Crybg1 ENSMUST00000200401.1 NM_001368305 uc287qxl.1 uc287qxl.2 Belongs to the beta/gamma-crystallin family. molecular_function cellular_component biological_process uc287qxl.1 uc287qxl.2 
ENSMUST00000200406.2 Igkv20-101-2 ENSMUST00000200406.2 Igkv20-101-2 (from geneSymbol) A0A0G2JDU3 A0A0G2JDU3_MOUSE ENSMUST00000200406.1 Igkv20-101-2 uc291fif.1 uc291fif.2 immunoglobulin production extracellular space immune response uc291fif.1 uc291fif.2 
ENSMUST00000200408.3 Mir7227 ENSMUST00000200408.3 microRNA 7227 (from RefSeq NR_106086.1) ENSMUST00000200408.1 ENSMUST00000200408.2 NR_106086 uc033ifg.1 uc033ifg.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033ifg.1 uc033ifg.2 
ENSMUST00000200411.2 Gm43413 ENSMUST00000200411.2 Gm43413 (from geneSymbol) AK037671 ENSMUST00000200411.1 uc290znt.1 uc290znt.2 uc290znt.1 uc290znt.2 
ENSMUST00000200412.2 4921511C10Rik ENSMUST00000200412.2 RIKEN cDNA 4921511C10 gene (from RefSeq NR_045502.1) ENSMUST00000200412.1 NR_045502 uc029umu.1 uc029umu.2 uc029umu.1 uc029umu.2 
ENSMUST00000200424.2 Gm43404 ENSMUST00000200424.2 Gm43404 (from geneSymbol) ENSMUST00000200424.1 uc290iwe.1 uc290iwe.2 uc290iwe.1 uc290iwe.2 
ENSMUST00000200442.2 Gm43473 ENSMUST00000200442.2 Gm43473 (from geneSymbol) ENSMUST00000200442.1 uc290kne.1 uc290kne.2 uc290kne.1 uc290kne.2 
ENSMUST00000200447.2 Gm21680 ENSMUST00000200447.2 predicted gene, 21680 (from RefSeq NM_001378644.1) A0A0G2JGR8 A0A0G2JGR8_MOUSE ENSMUST00000200447.1 Gm21680 NM_001378644 uc290tuw.1 uc290tuw.2 uc290tuw.1 uc290tuw.2 
ENSMUST00000200448.2 Gm43340 ENSMUST00000200448.2 Gm43340 (from geneSymbol) ENSMUST00000200448.1 LF195171 uc290zui.1 uc290zui.2 uc290zui.1 uc290zui.2 
ENSMUST00000200454.2 Igkv4-86 ENSMUST00000200454.2 Igkv4-86 (from geneSymbol) A0A0G2JGE7 A0A0G2JGE7_MOUSE ENSMUST00000200454.1 Igkv4-86 MG386926 uc291fjo.1 uc291fjo.2 immunoglobulin production extracellular space immune response uc291fjo.1 uc291fjo.2 
ENSMUST00000200458.3 Gm25203 ENSMUST00000200458.3 Gm25203 (from geneSymbol) ENSMUST00000200458.1 ENSMUST00000200458.2 uc288itl.1 uc288itl.2 uc288itl.1 uc288itl.2 
ENSMUST00000200461.2 Gm43831 ENSMUST00000200461.2 Gm43831 (from geneSymbol) ENSMUST00000200461.1 uc290vjp.1 uc290vjp.2 uc290vjp.1 uc290vjp.2 
ENSMUST00000200465.2 Gm10048 ENSMUST00000200465.2 Gm10048 (from geneSymbol) DQ699580 ENSMUST00000200465.1 uc290vka.1 uc290vka.2 uc290vka.1 uc290vka.2 
ENSMUST00000200466.5 Amph ENSMUST00000200466.5 amphiphysin, transcript variant 11 (from RefSeq NM_001426505.1) A0A0G2JEG8 A0A0G2JEG8_MOUSE Amph ENSMUST00000200466.1 ENSMUST00000200466.2 ENSMUST00000200466.3 ENSMUST00000200466.4 NM_001426505 uc007pon.1 uc007pon.2 uc007pon.3 uc007pon.4 phospholipid binding cytoplasm leading edge membrane uc007pon.1 uc007pon.2 uc007pon.3 uc007pon.4 
ENSMUST00000200467.2 Gm36070 ENSMUST00000200467.2 Gm36070 (from geneSymbol) AK080727 ENSMUST00000200467.1 uc290hhw.1 uc290hhw.2 uc290hhw.1 uc290hhw.2 
ENSMUST00000200469.5 Gm57858 ENSMUST00000200469.5 gene model 57858, transcript variant 2 (from RefSeq NM_178418.5) Ccdc144b E9PVZ3 E9PVZ3_MOUSE ENSMUST00000200469.1 ENSMUST00000200469.2 ENSMUST00000200469.3 ENSMUST00000200469.4 NM_178418 uc008ozd.1 uc008ozd.2 uc008ozd.3 molecular_function cellular_component biological_process uc008ozd.1 uc008ozd.2 uc008ozd.3 
ENSMUST00000200473.2 Gm42427 ENSMUST00000200473.2 Gm42427 (from geneSymbol) ENSMUST00000200473.1 FJ654076 uc290vfe.1 uc290vfe.2 uc290vfe.1 uc290vfe.2 
ENSMUST00000200487.2 Gm43336 ENSMUST00000200487.2 Gm43336 (from geneSymbol) AK161202 ENSMUST00000200487.1 uc290ync.1 uc290ync.2 uc290ync.1 uc290ync.2 
ENSMUST00000200494.3 4930596I21Rik ENSMUST00000200494.3 RIKEN cDNA 4930596I21 gene (from RefSeq NR_108103.1) ENSMUST00000200494.1 ENSMUST00000200494.2 NR_108103 uc007cwa.1 uc007cwa.2 uc007cwa.3 uc007cwa.4 uc007cwa.1 uc007cwa.2 uc007cwa.3 uc007cwa.4 
ENSMUST00000200495.2 Trgj1 ENSMUST00000200495.2 Trgj1 (from geneSymbol) A0A0G2JGW7 A0A0G2JGW7_MOUSE ENSMUST00000200495.1 Trgj1 Trgj2 uc288lbr.1 uc288lbr.2 uc288lbr.1 uc288lbr.2 
ENSMUST00000200496.2 Gm42926 ENSMUST00000200496.2 Gm42926 (from geneSymbol) AK076843 ENSMUST00000200496.1 uc290jdk.1 uc290jdk.2 uc290jdk.1 uc290jdk.2 
ENSMUST00000200502.2 Gm43846 ENSMUST00000200502.2 Gm43846 (from geneSymbol) ENSMUST00000200502.1 LF194137 uc290iki.1 uc290iki.2 uc290iki.1 uc290iki.2 
ENSMUST00000200507.2 Gm42822 ENSMUST00000200507.2 Gm42822 (from geneSymbol) AK141653 ENSMUST00000200507.1 uc290jzd.1 uc290jzd.2 uc290jzd.1 uc290jzd.2 
ENSMUST00000200508.5 S100a3 ENSMUST00000200508.5 S100 calcium binding protein A3, transcript variant 1 (from RefSeq NM_001355597.2) ENSMUST00000200508.1 ENSMUST00000200508.2 ENSMUST00000200508.3 ENSMUST00000200508.4 NM_001355597 Q496W1 Q496W1_MOUSE S100a3 uc290hdg.1 uc290hdg.2 Belongs to the S-100 family. calcium ion binding zinc ion binding metal ion binding transition metal ion binding uc290hdg.1 uc290hdg.2 
ENSMUST00000200523.2 Gm43703 ENSMUST00000200523.2 Gm43703 (from geneSymbol) BC043941 ENSMUST00000200523.1 uc291bhy.1 uc291bhy.2 uc291bhy.1 uc291bhy.2 
ENSMUST00000200525.2 Gm43108 ENSMUST00000200525.2 Gm43108 (from geneSymbol) AK206573 ENSMUST00000200525.1 uc290iyg.1 uc290iyg.2 uc290iyg.1 uc290iyg.2 
ENSMUST00000200535.6 Usp29 ENSMUST00000200535.6 ubiquitin specific peptidase 29, transcript variant 2 (from RefSeq NM_021323.4) C6EQG1 ENSMUST00000200535.1 ENSMUST00000200535.2 ENSMUST00000200535.3 ENSMUST00000200535.4 ENSMUST00000200535.5 NM_021323 Q9ES63 UBP29_MOUSE Usp29 uc291ldi.1 uc291ldi.2 Deubiquitinase involved in innate antiviral immunity by mediating 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Cytoplasm, perinuclear region Note=Localizes to perinuclear region in response to herpes simplex virus-1 (HSV-1) infection. Predominantly expressed in brain and testis (PubMed:30919279). Highest expression levels in adult brain, especially in the cerebral cortex and hippocampus, and in the forebrain, face, and limb buds of midgestation mouse embryos (PubMed:10958632). No visible phenotype in normal conditions. Belongs to the peptidase C19 family. G1/S transition of mitotic cell cycle cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity nucleus proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity uc291ldi.1 uc291ldi.2 
ENSMUST00000200537.2 Gm43289 ENSMUST00000200537.2 Gm43289 (from geneSymbol) ENSMUST00000200537.1 uc290vwg.1 uc290vwg.2 uc290vwg.1 uc290vwg.2 
ENSMUST00000200538.2 Gm42588 ENSMUST00000200538.2 Gm42588 (from geneSymbol) AK090353 ENSMUST00000200538.1 uc291ahf.1 uc291ahf.2 uc291ahf.1 uc291ahf.2 
ENSMUST00000200546.2 Syde2 ENSMUST00000200546.2 Syde2 (from geneSymbol) A0A0G2JEY9 A0A0G2JEY9_MOUSE AK049496 ENSMUST00000200546.1 Syde2 uc290kjl.1 uc290kjl.2 molecular_function signal transduction uc290kjl.1 uc290kjl.2 
ENSMUST00000200548.2 Trav9d-4 ENSMUST00000200548.2 Trav9d-4 (from geneSymbol) A0A0G2JG37 A0A0G2JG37_MOUSE AK138453 ENSMUST00000200548.1 Trav9d-4 uc288txw.1 uc288txw.2 uc288txw.1 uc288txw.2 
ENSMUST00000200557.3 Mir497 ENSMUST00000200557.3 microRNA 497 (from RefSeq NR_030444.1) ENSMUST00000200557.1 ENSMUST00000200557.2 NR_030444 uc011xxp.1 uc011xxp.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM609679.1 [ECO:0000345] ##Evidence-Data-END## uc011xxp.1 uc011xxp.2 
ENSMUST00000200561.2 Gm42723 ENSMUST00000200561.2 Gm42723 (from geneSymbol) AK038608 ENSMUST00000200561.1 uc289rvy.1 uc289rvy.2 uc289rvy.1 uc289rvy.2 
ENSMUST00000200568.2 Iglc1 ENSMUST00000200568.2 Iglc1 (from geneSymbol) A0A0G2JE99 A0A0G2JE99_MOUSE ENSMUST00000200568.1 Iglc1 uc289dgl.1 uc289dgl.2 antigen binding protein binding phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane B cell receptor complex immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc289dgl.1 uc289dgl.2 
ENSMUST00000200573.3 Mir9768 ENSMUST00000200573.3 microRNA 9768 (from RefSeq NR_128567.1) ENSMUST00000200573.1 ENSMUST00000200573.2 NR_128567 uc057akm.1 uc057akm.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc057akm.1 uc057akm.2 
ENSMUST00000200578.5 Igkv9-129 ENSMUST00000200578.5 Igkv9-129 (from geneSymbol) ENSMUST00000200578.1 ENSMUST00000200578.2 ENSMUST00000200578.3 ENSMUST00000200578.4 KV5A8_MOUSE M12191 P01641 uc291fgk.1 uc291fgk.2 adaptive immune response immune system process immunoglobulin production extracellular space immune response immunoglobulin complex uc291fgk.1 uc291fgk.2 
ENSMUST00000200579.2 Gm43505 ENSMUST00000200579.2 Gm43505 (from geneSymbol) ENSMUST00000200579.1 uc290vfw.1 uc290vfw.2 uc290vfw.1 uc290vfw.2 
ENSMUST00000200585.5 Fgf2 ENSMUST00000200585.5 fibroblast growth factor 2 (from RefSeq NM_008006.2) ENSMUST00000200585.1 ENSMUST00000200585.2 ENSMUST00000200585.3 ENSMUST00000200585.4 Fgf2 Fgf2a NM_008006 Q541T2 Q541T2_MOUSE uc008pap.1 uc008pap.2 uc008pap.3 uc008pap.4 Nucleus Secreted Belongs to the heparin-binding growth factors family. fibroblast growth factor receptor binding extracellular region nucleus cytoplasm aging growth factor activity positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway embryo development ending in birth or egg hatching paracrine signaling wound healing positive regulation of smooth muscle cell proliferation positive regulation of cardiac muscle cell proliferation angiogenesis involved in coronary vascular morphogenesis positive regulation of ERK1 and ERK2 cascade uc008pap.1 uc008pap.2 uc008pap.3 uc008pap.4 
ENSMUST00000200586.2 Igkv17-127 ENSMUST00000200586.2 Igkv17-127 (from geneSymbol) A0A0G2JDN5 A0A0G2JDN5_MOUSE ENSMUST00000200586.1 Igkv17-127 uc291fgm.1 uc291fgm.2 immunoglobulin production extracellular space immune response uc291fgm.1 uc291fgm.2 
ENSMUST00000200590.2 Gm43766 ENSMUST00000200590.2 Gm43766 (from geneSymbol) ENSMUST00000200590.1 LF273798 uc288tug.1 uc288tug.2 uc288tug.1 uc288tug.2 
ENSMUST00000200592.3 Gm32921 ENSMUST00000200592.3 Gm32921 (from geneSymbol) BC100515 ENSMUST00000200592.1 ENSMUST00000200592.2 uc057lmy.1 uc057lmy.2 uc057lmy.3 uc057lmy.4 uc057lmy.1 uc057lmy.2 uc057lmy.3 uc057lmy.4 
ENSMUST00000200599.2 Gm43272 ENSMUST00000200599.2 Gm43272 (from geneSymbol) AK138190 ENSMUST00000200599.1 uc290xoj.1 uc290xoj.2 uc290xoj.1 uc290xoj.2 
ENSMUST00000200604.3 Mir7686 ENSMUST00000200604.3 microRNA 7686 (from RefSeq NR_106157.1) ENSMUST00000200604.1 ENSMUST00000200604.2 NR_106157 uc033jct.1 uc033jct.2 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc033jct.1 uc033jct.2 
ENSMUST00000200607.5 Rnf216 ENSMUST00000200607.5 ring finger protein 216, transcript variant B (from RefSeq NM_207110.1) ENSMUST00000200607.1 ENSMUST00000200607.2 ENSMUST00000200607.3 ENSMUST00000200607.4 NM_207110 P58283 Q3U493 Q3UE56 Q3UGM3 Q68FN0 Q6P1H8 Q6PWY5 Q8BN27 Q8C1U3 RN216_MOUSE Triad3 Ubce7ip1 Uip83 Zin uc009ajn.1 uc009ajn.2 uc009ajn.3 uc009ajn.4 E3 ubiquitin ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their ubiquitination. Plays a role in the regulation of antiviral responses by promoting the degradation of TRAF3, TLR4 and TLR9. In turn, down-regulates NF-kappa-B and IRF3 activation as well as beta interferon production. Participates also in the regulation of autophagy by ubiquitinating BECN1 leading to its degradation and autophagy inhibition. Plays a role in ARC-dependent synaptic plasticity by mediating ARC ubiquitination resulting in its rapid proteasomal degradation (By similarity). Plays aso an essential role in spermatogenesis and male fertility (PubMed:30649198). Mechanistically, regulates meiosis by promoting the degradation of PRKACB through the ubiquitin-mediated lysosome pathway (PubMed:33724554). Modulates the gonadotropin-releasing hormone signal pathway by affecting the stability of STAU2 that is required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite (PubMed:37439148). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Allosterically activated by 'Lys-63'-linked di- ubiquitin. Protein modification; protein ubiquitination. Interacts with UBE2L3 and to some extent with UBE2L6. Interacts with TRAF3, TLR3, TLR4, TLR5 and TLR9. Isoform 3/ZIN binds RIPK1. Cytoplasm Cytoplasmic vesicle, clathrin-coated vesicle Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=TRIAD3A, a; IsoId=P58283-1; Sequence=Displayed; Name=2; Synonyms=TRIAD3B, b; IsoId=P58283-2; Sequence=VSP_007408; Name=3; IsoId=P58283-3; Sequence=VSP_019293, VSP_019294; The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. Auto-ubiquitinated. Phosphorylation at Ser-719 enhances acceptor ubiquitin binding and chain-type specificity towards 'Lys-63' di-ubiquitin but not di- ubiquitin with other linkage types. Deletion mutant mice are viable and grossly indistinguishable from heterozygous littermates (PubMed:30649198). However, knockout leads to infertility in male but not female mice (PubMed:30649198, PubMed:33724554). In addition, RNF216-deficiency leads to down-regulation of the gonadotropin-releasing hormone signal pathway (PubMed:37439148). nucleus nucleoplasm cytoplasm cytosol apoptotic process protein ubiquitination transferase activity regulation of interferon-beta production proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding regulation of defense response to virus by host ubiquitin protein ligase activity protein K48-linked ubiquitination postsynaptic endocytic zone glutamatergic synapse protein catabolic process, modulating synaptic transmission uc009ajn.1 uc009ajn.2 uc009ajn.3 uc009ajn.4 
ENSMUST00000200608.2 Gm42710 ENSMUST00000200608.2 Gm42710 (from geneSymbol) ENSMUST00000200608.1 uc290krd.1 uc290krd.2 uc290krd.1 uc290krd.2 
ENSMUST00000200609.2 Trav7-5 ENSMUST00000200609.2 Trav7-5 (from geneSymbol) A0A0G2JFX6 A0A0G2JFX6_MOUSE AY056585 ENSMUST00000200609.1 Trav7-5 uc288uag.1 uc288uag.2 uc288uag.1 uc288uag.2 
ENSMUST00000200612.2 Gm42975 ENSMUST00000200612.2 Gm42975 (from geneSymbol) AK050929 ENSMUST00000200612.1 uc290thn.1 uc290thn.2 uc290thn.1 uc290thn.2 
ENSMUST00000200614.2 Gm43195 ENSMUST00000200614.2 Gm43195 (from geneSymbol) ENSMUST00000200614.1 LF204603 uc291bhf.1 uc291bhf.2 uc291bhf.1 uc291bhf.2 
ENSMUST00000200632.2 Gm43183 ENSMUST00000200632.2 Gm43183 (from geneSymbol) BC115471 ENSMUST00000200632.1 uc290vem.1 uc290vem.2 uc290vem.1 uc290vem.2 
ENSMUST00000200633.2 Dnase2b ENSMUST00000200633.2 deoxyribonuclease II beta, transcript variant 1 (from RefSeq NM_019957.5) DNS2B_MOUSE Dlad ENSMUST00000200633.1 NM_019957 Q8C589 Q9QY48 uc008rro.1 uc008rro.2 uc008rro.3 uc008rro.4 Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation. Reaction=Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'- phosphooligonucleotide end-products.; EC=3.1.22.1; Lysosome Highly expressed in the eye lens. Detected in liver, but not in the other tissues tested. Inhibited by aurintricarboxylic acid and Zn(2+). Belongs to the DNase II family. nuclease activity endonuclease activity endodeoxyribonuclease activity deoxyribonuclease II activity extracellular region cytoplasm lysosome DNA metabolic process apoptotic DNA fragmentation hydrolase activity uc008rro.1 uc008rro.2 uc008rro.3 uc008rro.4 
ENSMUST00000200640.2 E330034L11Rik ENSMUST00000200640.2 E330034L11Rik (from geneSymbol) ENSMUST00000200640.1 LF194071 uc290hpw.1 uc290hpw.2 uc290hpw.1 uc290hpw.2 
ENSMUST00000200644.2 Gm42653 ENSMUST00000200644.2 Gm42653 (from geneSymbol) DQ714125 ENSMUST00000200644.1 uc290wep.1 uc290wep.2 uc290wep.1 uc290wep.2 
ENSMUST00000200646.2 Gm42989 ENSMUST00000200646.2 Gm42989 (from geneSymbol) AK145476 ENSMUST00000200646.1 uc291ahz.1 uc291ahz.2 uc291ahz.1 uc291ahz.2 
ENSMUST00000200652.2 Gm43187 ENSMUST00000200652.2 Gm43187 (from geneSymbol) ENSMUST00000200652.1 LF305587 uc291aic.1 uc291aic.2 uc291aic.1 uc291aic.2 
ENSMUST00000200654.3 Mir466c-1 ENSMUST00000200654.3 microRNA 466c-1 (from RefSeq NR_130320.1) ENSMUST00000200654.1 ENSMUST00000200654.2 NR_130320 uc056zjx.1 uc056zjx.2 uc056zjx.3 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc056zjx.1 uc056zjx.2 uc056zjx.3 
ENSMUST00000200664.2 Gm43654 ENSMUST00000200664.2 Gm43654 (from geneSymbol) AK157539 ENSMUST00000200664.1 uc290jon.1 uc290jon.2 uc290jon.1 uc290jon.2 
ENSMUST00000200668.2 Gm42917 ENSMUST00000200668.2 Gm42917 (from geneSymbol) ENSMUST00000200668.1 uc290zev.1 uc290zev.2 uc290zev.1 uc290zev.2 
ENSMUST00000200675.2 Gm43506 ENSMUST00000200675.2 Gm43506 (from geneSymbol) AK148944 ENSMUST00000200675.1 uc290vft.1 uc290vft.2 uc290vft.1 uc290vft.2 
ENSMUST00000200678.2 Gm43807 ENSMUST00000200678.2 Gm43807 (from geneSymbol) AK136680 ENSMUST00000200678.1 uc291cdi.1 uc291cdi.2 uc291cdi.1 uc291cdi.2 
ENSMUST00000200680.4 Tprkb ENSMUST00000200680.4 Tp53rk binding protein, transcript variant 3 (from RefSeq NM_001362064.1) ENSMUST00000200680.1 ENSMUST00000200680.2 ENSMUST00000200680.3 NM_001362064 Q8QZZ7 TPRKB_MOUSE Tprkb uc291glt.1 uc291glt.2 Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification. Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes. Interacts with TP53RK/PRPK. Cytoplasm, cytosol Nucleus Mouse embryos display primary microcephaly characterized by significantly shorter cortex lengths, cortex-midbrain midline lengths and cortex widths. Mice do not show a renal phenotype. Belongs to the CGI121/TPRKB family. EKC/KEOPS complex tRNA threonylcarbamoyladenosine modification nucleus cytoplasm cytosol tRNA processing protein kinase binding uc291glt.1 uc291glt.2 
ENSMUST00000200681.4 Cxcl2 ENSMUST00000200681.4 Secreted (from UniProt Q3U1L9) AK155874 Cxcl2 ENSMUST00000200681.1 ENSMUST00000200681.2 ENSMUST00000200681.3 Q3U1L9 Q3U1L9_MOUSE uc008ybn.1 uc008ybn.2 uc008ybn.3 Secreted Belongs to the intercrine alpha (chemokine CxC) family. cytokine activity extracellular region extracellular space chemotaxis defense response immune response signal transduction chemokine activity cell chemotaxis uc008ybn.1 uc008ybn.2 uc008ybn.3 
ENSMUST00000200689.5 Or10j27 ENSMUST00000200689.5 olfactory receptor family 10 subfamily J member 27 (from RefSeq NM_146764.2) ENSMUST00000200689.1 ENSMUST00000200689.2 ENSMUST00000200689.3 ENSMUST00000200689.4 NM_146764 Olfr1408 Or10j27 Q8VG32 Q8VG32_MOUSE uc007dra.1 uc007dra.2 uc007dra.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB173242.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007dra.1 uc007dra.2 uc007dra.3 
ENSMUST00000200696.2 Gm43084 ENSMUST00000200696.2 Gm43084 (from geneSymbol) AK051408 ENSMUST00000200696.1 uc290wrf.1 uc290wrf.2 uc290wrf.1 uc290wrf.2 
ENSMUST00000200697.2 Gm42528 ENSMUST00000200697.2 Gm42528 (from geneSymbol) ENSMUST00000200697.1 uc290vce.1 uc290vce.2 uc290vce.1 uc290vce.2 
ENSMUST00000200700.2 Gm30003 ENSMUST00000200700.2 Gm30003 (from geneSymbol) AK045677 ENSMUST00000200700.1 uc291ama.1 uc291ama.2 uc291ama.1 uc291ama.2 
ENSMUST00000200723.2 Gm42736 ENSMUST00000200723.2 Gm42736 (from geneSymbol) ENSMUST00000200723.1 uc290wcy.1 uc290wcy.2 uc290wcy.1 uc290wcy.2 
ENSMUST00000200726.2 Gm43851 ENSMUST00000200726.2 Gm43851 (from geneSymbol) ENSMUST00000200726.1 uc290unf.1 uc290unf.2 uc290unf.1 uc290unf.2 
ENSMUST00000200745.2 Pramel33 ENSMUST00000200745.2 Belongs to the PRAME family. (from UniProt A0A0J9YU00) A0A0J9YU00 A0A0J9YU00_MOUSE ENSMUST00000200745.1 Pramel33 uc290xem.1 uc290xem.2 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xem.1 uc290xem.2 
ENSMUST00000200747.2 Gm42668 ENSMUST00000200747.2 Gm42668 (from geneSymbol) AK156978 ENSMUST00000200747.1 uc290whg.1 uc290whg.2 uc290whg.1 uc290whg.2 
ENSMUST00000200749.2 4933424N20Rik ENSMUST00000200749.2 RIKEN cDNA 4933424N20 gene (from RefSeq NR_190004.1) ENSMUST00000200749.1 NR_190004 uc290yww.1 uc290yww.2 uc290yww.1 uc290yww.2 
ENSMUST00000200753.2 1700025A08Rik ENSMUST00000200753.2 1700025A08Rik (from geneSymbol) AK006317 ENSMUST00000200753.1 uc290wcg.1 uc290wcg.2 uc290wcg.1 uc290wcg.2 
ENSMUST00000200755.2 4930524B17Rik ENSMUST00000200755.2 RIKEN cDNA 4930524B17 gene (from RefSeq NR_126084.1) ENSMUST00000200755.1 NR_126084 uc057acj.1 uc057acj.2 uc057acj.1 uc057acj.2 
ENSMUST00000200757.2 A330058E17Rik ENSMUST00000200757.2 A330058E17Rik (from geneSymbol) AK039541 ENSMUST00000200757.1 uc290wjz.1 uc290wjz.2 uc290wjz.1 uc290wjz.2 
ENSMUST00000200758.4 Ube3a ENSMUST00000200758.4 ubiquitin protein ligase E3A, transcript variant 2 (from RefSeq NM_011668.3) E9QKT1 ENSMUST00000200758.1 ENSMUST00000200758.2 ENSMUST00000200758.3 NM_011668 O08759 P97482 Q8CE29 UBE3A_MOUSE Ube3a uc009hei.1 uc009hei.2 uc009hei.3 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:20211139, PubMed:24728990, PubMed:30020076). Several substrates have been identified including the BMAL1, ARC, LAMTOR1, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:20211139, PubMed:24728990, PubMed:30020076). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo (By similarity). Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (PubMed:20211139). Required for synaptic remodeling in neurons by mediating ubiquitination and degradation of LAMTOR1, thereby limiting mTORC1 signaling and activity-dependent synaptic remodeling (PubMed:30020076). Synergizes with WBP2 in enhancing PGR activity (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence= Protein modification; protein ubiquitination. The active form is probably a homotrimer. Binds UBQLN1 and UBQLN2. Interacts with the 26S proteasome. Interacts with BPY2. Interacts with HIF1AN, MAPK6 and NEURL4; interaction with MAPK6 may be mediated by NEURL4. Interacts with the proteasomal subunit PSMD4. Interacts with BMAL1 (PubMed:24728990). Interacts with ARC (PubMed:20211139). Interacts with ESR1 and WBP2 (By similarity). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O08759-1; Sequence=Displayed; Name=2; IsoId=O08759-2; Sequence=VSP_057563; Name=3; IsoId=O08759-3; Sequence=VSP_057563, VSP_057564; Widely expressed. Most abundant in brain, heart and thymus. Up-regulated in response to neuronal activity. Phosphorylation at Tyr-654 by ABL1 impairs E3 ligase activity. Mice with maternal deficiency display autism spectrum disorders, characterized by motor dysfunction, inducible seizures and a context-dependent learning deficit (PubMed:9808466, PubMed:11895368). Long-term potentiation (LTP) is severely impaired despite normal baseline synaptic transmission and neuroanatomy (PubMed:9808466). The cytoplasmic abundance of p53/TP53 is increased in postmitotic neurons (PubMed:9808466). Accumulation of ARC protein in neurons, resulting in the excessive internalization of AMPA receptors (AMPARs) at synapses and impaired synaptic function (PubMed:20211139). The Ube3a locus is imprinted with silencing of the paternal allele in hippocampus and cerebellum in mice. A cysteine residue is required for ubiquitin-thioester formation. Sequence=AAB47756.1; Type=Frameshift; Evidence=; proteasome complex ovarian follicle development transcription coactivator activity ubiquitin-protein transferase activity protein binding nucleus cytoplasm cytosol ubiquitin-dependent protein catabolic process positive regulation of phosphatidylinositol 3-kinase signaling protein ubiquitination transferase activity androgen receptor signaling pathway positive regulation of protein ubiquitination response to progesterone sperm entry response to cocaine response to hydrogen peroxide regulation of circadian rhythm positive regulation of transcription from RNA polymerase II promoter metal ion binding rhythmic process progesterone receptor signaling pathway protein autoubiquitination prostate gland growth negative regulation of dendritic spine morphogenesis ubiquitin protein ligase activity protein K48-linked ubiquitination cellular response to brain-derived neurotrophic factor stimulus regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process uc009hei.1 uc009hei.2 uc009hei.3 
ENSMUST00000200761.2 Gm42895 ENSMUST00000200761.2 Gm42895 (from geneSymbol) ENSMUST00000200761.1 uc291djq.1 uc291djq.2 uc291djq.1 uc291djq.2 
ENSMUST00000200763.2 Gm42885 ENSMUST00000200763.2 Gm42885 (from geneSymbol) DQ699077 ENSMUST00000200763.1 uc291akx.1 uc291akx.2 uc291akx.1 uc291akx.2 
ENSMUST00000200768.2 4930589O11Rik ENSMUST00000200768.2 4930589O11Rik (from geneSymbol) ENSMUST00000200768.1 uc290vwo.1 uc290vwo.2 uc290vwo.1 uc290vwo.2 
ENSMUST00000200773.2 Gm43694 ENSMUST00000200773.2 Gm43694 (from geneSymbol) AK139779 ENSMUST00000200773.1 uc290ukk.1 uc290ukk.2 uc290ukk.1 uc290ukk.2 
ENSMUST00000200774.2 Gm42648 ENSMUST00000200774.2 Gm42648 (from geneSymbol) AK037187 ENSMUST00000200774.1 uc290vxu.1 uc290vxu.2 uc290vxu.1 uc290vxu.2 
ENSMUST00000200788.2 Gm42894 ENSMUST00000200788.2 Gm42894 (from geneSymbol) AB350759 ENSMUST00000200788.1 uc291agi.1 uc291agi.2 uc291agi.1 uc291agi.2 
ENSMUST00000200791.2 Gm43458 ENSMUST00000200791.2 Gm43458 (from geneSymbol) ENSMUST00000200791.1 uc290uqk.1 uc290uqk.2 uc290uqk.1 uc290uqk.2 
ENSMUST00000200801.2 Gm43479 ENSMUST00000200801.2 Gm43479 (from geneSymbol) ENSMUST00000200801.1 uc291dqr.1 uc291dqr.2 uc291dqr.1 uc291dqr.2 
ENSMUST00000200814.2 4930421C12Rik ENSMUST00000200814.2 4930421C12Rik (from geneSymbol) ENSMUST00000200814.1 uc290vca.1 uc290vca.2 uc290vca.1 uc290vca.2 
ENSMUST00000200819.2 Gm3289 ENSMUST00000200819.2 Gm3289 (from geneSymbol) AK040992 ENSMUST00000200819.1 uc009bas.1 uc009bas.2 uc009bas.1 uc009bas.2 
ENSMUST00000200820.3 Gm36186 ENSMUST00000200820.3 Gm36186 (from geneSymbol) AK054439 ENSMUST00000200820.1 ENSMUST00000200820.2 uc291bxw.1 uc291bxw.2 uc291bxw.3 uc291bxw.1 uc291bxw.2 uc291bxw.3 
ENSMUST00000200829.4 Scn2a ENSMUST00000200829.4 sodium channel, voltage-gated, type II, alpha, transcript variant 3 (from RefSeq NM_001346680.1) A0A5H1ZRM8 A0A5H1ZRM8_MOUSE ENSMUST00000200829.1 ENSMUST00000200829.2 ENSMUST00000200829.3 NM_001346680 Scn2a uc289wmw.1 uc289wmw.2 Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. In humans, variants of this gene are associated with seizure disorders and autism spectrum disorder. Mice homozygous for a knockout mutation die with severe hypoxia and extensive neuronal cell death, while gain of function mutations result in progressive seizure disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.129288.1, SRR1660811.225923.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the sodium channel (TC 1.A.1.10) family. Lacks conserved residue(s) required for the propagation of feature annotation. uc289wmw.1 uc289wmw.2 
ENSMUST00000200842.2 Gm43165 ENSMUST00000200842.2 Gm43165 (from geneSymbol) ENSMUST00000200842.1 uc291agm.1 uc291agm.2 uc291agm.1 uc291agm.2 
ENSMUST00000200846.2 Potefam3c ENSMUST00000200846.2 Potefam3c (from geneSymbol) A0A0J9YUZ3 A0A0J9YUZ3_MOUSE ENSMUST00000200846.1 Gm9495 Potefam3c uc292akl.1 uc292akl.2 molecular_function cellular_component biological_process uc292akl.1 uc292akl.2 
ENSMUST00000200848.2 Gm42856 ENSMUST00000200848.2 Gm42856 (from geneSymbol) AK137822 ENSMUST00000200848.1 uc291cxo.1 uc291cxo.2 uc291cxo.1 uc291cxo.2 
ENSMUST00000200853.2 Gm42798 ENSMUST00000200853.2 Gm42798 (from geneSymbol) ENSMUST00000200853.1 uc290ufq.1 uc290ufq.2 uc290ufq.1 uc290ufq.2 
ENSMUST00000200867.2 Gm43457 ENSMUST00000200867.2 Gm43457 (from geneSymbol) ENSMUST00000200867.1 LF194916 uc290ura.1 uc290ura.2 uc290ura.1 uc290ura.2 
ENSMUST00000200872.2 Gm42930 ENSMUST00000200872.2 Gm42930 (from geneSymbol) AK084807 ENSMUST00000200872.1 uc290zdz.1 uc290zdz.2 uc290zdz.1 uc290zdz.2 
ENSMUST00000200879.2 Gm42787 ENSMUST00000200879.2 Gm42787 (from geneSymbol) AK039907 ENSMUST00000200879.1 uc291bza.1 uc291bza.2 uc291bza.1 uc291bza.2 
ENSMUST00000200880.4 Cxcl17 ENSMUST00000200880.4 C-X-C motif chemokine ligand 17 (from RefSeq NM_153576.2) CXL17_MOUSE ENSMUST00000200880.1 ENSMUST00000200880.2 ENSMUST00000200880.3 NM_153576 Q5UW37 Vcc1 uc009fst.1 uc009fst.2 Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells (PubMed:24973458). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774). Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C- X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions. Secreted Detected in lung, trachea, lung, tongue thyroid, submaxillary gland, epididymis, and uterus tissues and at a lower level in ovary, prostate and in intestinal tissues. Likely to undergo an endoproteolytic process to form a four- cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion. Mice show no defects in breeding or gross anatomy development, and they gained weight normally but exhibit a paucity of macrophages in the lungs (PubMed:24973458). All the mice injected with NIH3T3 cells over-expressing Cxcl17 develop rapidly progressing tumors within 21 days. Belongs to the intercrine alpha (chemokine CxC) family. activation of MAPK activity angiogenesis extracellular region extracellular space cell chemotaxis positive regulation of cytosolic calcium ion concentration multicellular organism development chemokine activity positive regulation of vascular endothelial growth factor production positive regulation of macrophage chemotaxis cell differentiation macrophage chemotaxis negative regulation of inflammatory response chemokine-mediated signaling pathway positive regulation of monocyte chemotaxis uc009fst.1 uc009fst.2 
ENSMUST00000200886.3 A330070K13Rik ENSMUST00000200886.3 A330070K13Rik (from geneSymbol) AK039605 ENSMUST00000200886.1 ENSMUST00000200886.2 uc291agd.1 uc291agd.2 uc291agd.3 uc291agd.1 uc291agd.2 uc291agd.3 
ENSMUST00000200887.2 Gm43298 ENSMUST00000200887.2 Gm43298 (from geneSymbol) ENSMUST00000200887.1 uc291cdn.1 uc291cdn.2 uc291cdn.1 uc291cdn.2 
ENSMUST00000200889.4 Zfp433 ENSMUST00000200889.4 zinc finger protein 433, transcript variant 1 (from RefSeq NM_001243067.1) A0A0J9YUD4 A0A0J9YUD4_MOUSE ENSMUST00000200889.1 ENSMUST00000200889.2 ENSMUST00000200889.3 NM_001243067 Zfp433 uc007gjf.1 uc007gjf.2 uc007gjf.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc007gjf.1 uc007gjf.2 uc007gjf.3 
ENSMUST00000200893.4 Gm42109 ENSMUST00000200893.4 Gm42109 (from geneSymbol) ENSMUST00000200893.1 ENSMUST00000200893.2 ENSMUST00000200893.3 uc290wyu.1 uc290wyu.2 uc290wyu.1 uc290wyu.2 
ENSMUST00000200900.2 Gm43553 ENSMUST00000200900.2 Gm43553 (from geneSymbol) ENSMUST00000200900.1 uc291bxf.1 uc291bxf.2 uc291bxf.1 uc291bxf.2 
ENSMUST00000200907.2 4930519E07Rik ENSMUST00000200907.2 4930519E07Rik (from geneSymbol) AK015840 ENSMUST00000200907.1 uc290vcl.1 uc290vcl.2 uc290vcl.1 uc290vcl.2 
ENSMUST00000200910.4 Eno4 ENSMUST00000200910.4 enolase 4 (from RefSeq NM_178689.5) A0A0J9YUP0 A0A0J9YUP0_MOUSE ENSMUST00000200910.1 ENSMUST00000200910.2 ENSMUST00000200910.3 Eno4 NM_178689 uc012bob.1 uc012bob.2 Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 4/5. Belongs to the enolase family. phosphopyruvate hydratase complex magnesium ion binding phosphopyruvate hydratase activity glycolytic process uc012bob.1 uc012bob.2 
ENSMUST00000200913.2 4930480C01Rik ENSMUST00000200913.2 4930480C01Rik (from geneSymbol) ENSMUST00000200913.1 uc290vyj.1 uc290vyj.2 uc290vyj.1 uc290vyj.2 
ENSMUST00000200914.5 Zfp811 ENSMUST00000200914.5 zinc finger protein 811, transcript variant 1 (from RefSeq NM_183177.3) A0A0J9YU71 A0A0J9YU71_MOUSE ENSMUST00000200914.1 ENSMUST00000200914.2 ENSMUST00000200914.3 ENSMUST00000200914.4 NM_183177 Zfp811 uc008bxn.1 uc008bxn.2 uc008bxn.3 uc008bxn.4 May be involved in transcriptional regulation. molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008bxn.1 uc008bxn.2 uc008bxn.3 uc008bxn.4 
ENSMUST00000200918.2 Gm7538 ENSMUST00000200918.2 predicted gene 7538 (from RefSeq NR_046033.1) ENSMUST00000200918.1 NR_046033 uc008zgq.1 uc008zgq.2 uc008zgq.3 uc008zgq.1 uc008zgq.2 uc008zgq.3 
ENSMUST00000200924.2 4933430H06Rik ENSMUST00000200924.2 4933430H06Rik (from geneSymbol) AK016992 ENSMUST00000200924.1 uc290yxd.1 uc290yxd.2 uc290yxd.1 uc290yxd.2 
ENSMUST00000200925.2 Gm35191 ENSMUST00000200925.2 predicted gene, 35191 (from RefSeq NR_168085.1) ENSMUST00000200925.1 NR_168085 uc290vci.1 uc290vci.2 uc290vci.1 uc290vci.2 
ENSMUST00000200927.2 Gm43198 ENSMUST00000200927.2 Gm43198 (from geneSymbol) ENSMUST00000200927.1 uc291cgi.1 uc291cgi.2 uc291cgi.1 uc291cgi.2 
ENSMUST00000200931.2 Gm43150 ENSMUST00000200931.2 Gm43150 (from geneSymbol) ENSMUST00000200931.1 uc291cab.1 uc291cab.2 uc291cab.1 uc291cab.2 
ENSMUST00000200934.2 Gm19719 ENSMUST00000200934.2 Gm19719 (from geneSymbol) AK036547 ENSMUST00000200934.1 uc009apq.1 uc009apq.2 uc009apq.1 uc009apq.2 
ENSMUST00000200940.2 Gm45495 ENSMUST00000200940.2 Gm45495 (from geneSymbol) ENSMUST00000200940.1 uc290voa.1 uc290voa.2 uc290voa.1 uc290voa.2 
ENSMUST00000200948.2 Pagr1a ENSMUST00000200948.2 Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (PubMed:26744420). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (PubMed:26744420). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (By similarity). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (By similarity). May be involved in the regulation of the BMP pathway in extraembryonic development (PubMed:24633704). (from UniProt Q99L02) BC003932 ENSMUST00000200948.1 PGR1A_MOUSE Pa1 Pagr Pagr1a Q99L02 uc291vrh.1 uc291vrh.2 Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (PubMed:26744420). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (PubMed:26744420). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (By similarity). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (By similarity). May be involved in the regulation of the BMP pathway in extraembryonic development (PubMed:24633704). Component of the KMT2 family MLL2/MLL3 complex, at least composed of the histone methyltransferases KMT2D and/or KMT2C, the common subunits ASH2L, RBBP5, WDR5 and DPY30, and the complex type- specific subunits PAXIP1/PTIP, PAGR1, NCOA6 and KDM6A; PAXIP1 is required for the association with the MLL2/MLL3 complex (By similarity). Forms a constitutive complex with PAXIP1/PTIP independently of the MLL2/MLL3 complex (PubMed:19124460, PubMed:26744420). Interacts with NCOA1, ESR1, NR3C1, AR (By similarity). Q99L02; Q6NZQ4: Paxip1; NbExp=11; IntAct=EBI-11667455, EBI-1395317; Nucleus Expression first detected at 5.0-6.0 dpc in the extraembryonic region, at 7.5 dpc detected within the chorion; later the expression is expanding to the entire embryo. Normal germ layer specification and developmental patterning but limited anterior development and arrest by 8.5 dpc, likely due at least in part to defects in extraembryonic tissue. The terminology of MLL proteins in mammalia is not consistent also concerning the terminology of MLL protein-containing complexes. The decribed MLL2/MLL3 complex is commonly described as MLL3/MLL4 complex in literature. protein binding nucleus nucleoplasm DNA repair DNA recombination cellular response to DNA damage stimulus estrogen receptor binding positive regulation of intracellular estrogen receptor signaling pathway histone methyltransferase complex MLL3/4 complex positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgG isotypes histone H3-K4 methylation chorion development histone H3-K27 demethylation regulation of cell cycle G2/M phase transition positive regulation of cell cycle G1/S phase transition positive regulation of response to DNA damage stimulus uc291vrh.1 uc291vrh.2 
ENSMUST00000200950.2 Gm10441 ENSMUST00000200950.2 predicted gene 10441 (from RefSeq NR_188773.1) ENSMUST00000200950.1 NR_188773 uc290vof.1 uc290vof.2 uc290vof.1 uc290vof.2 
ENSMUST00000200968.4 Hyal5 ENSMUST00000200968.4 hyaluronoglucosaminidase 5, transcript variant 1 (from RefSeq NM_028957.3) ENSMUST00000200968.1 ENSMUST00000200968.2 ENSMUST00000200968.3 HYAL5_MOUSE Hyal5 NM_028957 Q812F3 uc009bcb.1 uc009bcb.2 Catalyzes the hydrolysis of hyaluronan into smaller oligosaccharide fragments (PubMed:16330764, PubMed:16925524, PubMed:19605784). Does not appear to be essential for fertilization (PubMed:19605784). Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D- glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35; Evidence= pH dependence: Optimum pH is 5-7. Cell membrane ipid-anchor, GPI-anchor Cytoplasmic vesicle, secretory vesicle, acrosome membrane Secreted Note=Located on the plasma and acrosomal membranes of acrosome-intact (AI) sperm and released during the acrosome reaction. Expressed in testis, epididymal sperm and epididymides (at protein level) (PubMed:16330764, PubMed:19605784). Expressed at highest levels in testis with lesser amounts in epididymal sperm (PubMed:16925524, PubMed:16330764, PubMed:19605784). Detected in the developing testis at postnatal day 20, with increasing levels through development. No visible phenotype. Viable and fertile. Belongs to the glycosyl hydrolase 56 family. acrosomal vesicle acrosomal membrane catalytic activity hyalurononglucosaminidase activity extracellular region plasma membrane carbohydrate metabolic process penetration of zona pellucida fusion of sperm to egg plasma membrane metabolic process external side of plasma membrane membrane hydrolase activity hydrolase activity, acting on glycosyl bonds anchored component of membrane cytoplasmic vesicle uc009bcb.1 uc009bcb.2 
ENSMUST00000200971.2 Gm43794 ENSMUST00000200971.2 Gm43794 (from geneSymbol) AK080505 ENSMUST00000200971.1 uc290vzv.1 uc290vzv.2 uc290vzv.1 uc290vzv.2 
ENSMUST00000200976.4 ENSMUSG00000121439 ENSMUST00000200976.4 ENSMUSG00000121439 (from geneSymbol) ENSMUST00000200976.1 ENSMUST00000200976.2 ENSMUST00000200976.3 uc290ukh.1 uc290ukh.2 uc290ukh.1 uc290ukh.2 
ENSMUST00000200980.2 Gm43230 ENSMUST00000200980.2 Gm43230 (from geneSymbol) ENSMUST00000200980.1 uc290wdn.1 uc290wdn.2 uc290wdn.1 uc290wdn.2 
ENSMUST00000200982.2 Gm42558 ENSMUST00000200982.2 Gm42558 (from geneSymbol) ENSMUST00000200982.1 uc291cbf.1 uc291cbf.2 uc291cbf.1 uc291cbf.2 
ENSMUST00000201004.2 Gm43102 ENSMUST00000201004.2 Gm43102 (from geneSymbol) ENSMUST00000201004.1 uc290wmd.1 uc290wmd.2 uc290wmd.1 uc290wmd.2 
ENSMUST00000201006.2 Gm43069 ENSMUST00000201006.2 Gm43069 (from geneSymbol) ENSMUST00000201006.1 uc290zdk.1 uc290zdk.2 uc290zdk.1 uc290zdk.2 
ENSMUST00000201009.2 Gm42931 ENSMUST00000201009.2 Gm42931 (from geneSymbol) ENSMUST00000201009.1 uc291dnl.1 uc291dnl.2 uc291dnl.1 uc291dnl.2 
ENSMUST00000201010.2 Med13l ENSMUST00000201010.2 mediator complex subunit 13-like, transcript variant 1 (from RefSeq NM_001347445.2) A0A0J9YUA8 A0A0J9YUA8_MOUSE ENSMUST00000201010.1 Med13l NM_001347445 uc008zgn.1 uc008zgn.2 uc008zgn.3 uc008zgn.4 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Nucleus Belongs to the Mediator complex subunit 13 family. transcription cofactor activity nucleus regulation of transcription from RNA polymerase II promoter mediator complex uc008zgn.1 uc008zgn.2 uc008zgn.3 uc008zgn.4 
ENSMUST00000201018.2 Gm43810 ENSMUST00000201018.2 Gm43810 (from geneSymbol) ENSMUST00000201018.1 uc290ujb.1 uc290ujb.2 uc290ujb.1 uc290ujb.2 
ENSMUST00000201019.3 Gm43775 ENSMUST00000201019.3 Gm43775 (from geneSymbol) ENSMUST00000201019.1 ENSMUST00000201019.2 uc290vzb.1 uc290vzb.2 uc290vzb.3 uc290vzb.1 uc290vzb.2 uc290vzb.3 
ENSMUST00000201027.2 Gm43342 ENSMUST00000201027.2 Gm43342 (from geneSymbol) ENSMUST00000201027.1 uc290zan.1 uc290zan.2 uc290zan.1 uc290zan.2 
ENSMUST00000201031.4 Pramel46 ENSMUST00000201031.4 Belongs to the PRAME family. (from UniProt A0A0J9YVD0) A0A0J9YVD0 A0A0J9YVD0_MOUSE ENSMUST00000201031.1 ENSMUST00000201031.2 ENSMUST00000201031.3 Pramel46 uc290xgc.1 uc290xgc.2 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xgc.1 uc290xgc.2 
ENSMUST00000201035.3 4933425D22Rik ENSMUST00000201035.3 RIKEN cDNA 4933425D22 gene (from RefSeq NR_190003.1) ENSMUST00000201035.1 ENSMUST00000201035.2 NR_190003 uc291cag.1 uc291cag.2 uc291cag.3 uc291cag.1 uc291cag.2 uc291cag.3 
ENSMUST00000201036.2 Gm43785 ENSMUST00000201036.2 Gm43785 (from geneSymbol) ENSMUST00000201036.1 uc290zae.1 uc290zae.2 uc290zae.1 uc290zae.2 
ENSMUST00000201039.2 Gm43168 ENSMUST00000201039.2 Gm43168 (from geneSymbol) ENSMUST00000201039.1 LF195395 uc291djy.1 uc291djy.2 uc291djy.1 uc291djy.2 
ENSMUST00000201047.4 Gm5141 ENSMUST00000201047.4 predicted gene 5141 (from RefSeq NM_001256065.1) A0A0J9YUW3 A0A0J9YUW3_MOUSE ENSMUST00000201047.1 ENSMUST00000201047.2 ENSMUST00000201047.3 Gm5141 NM_001256065 uc007qxe.1 uc007qxe.2 Nucleus transcription regulatory region sequence-specific DNA binding nucleic acid binding cellular_component nucleus regulation of transcription, DNA-templated metal ion binding uc007qxe.1 uc007qxe.2 
ENSMUST00000201049.2 Gm43266 ENSMUST00000201049.2 Gm43266 (from geneSymbol) ENSMUST00000201049.1 uc290vox.1 uc290vox.2 uc290vox.1 uc290vox.2 
ENSMUST00000201051.2 Gm42803 ENSMUST00000201051.2 Gm42803 (from geneSymbol) ENSMUST00000201051.1 LF194997 uc290wln.1 uc290wln.2 uc290wln.1 uc290wln.2 
ENSMUST00000201056.2 Gm42473 ENSMUST00000201056.2 Gm42473 (from geneSymbol) AK137591 ENSMUST00000201056.1 uc290yvy.1 uc290yvy.2 uc290yvy.1 uc290yvy.2 
ENSMUST00000201067.2 Gm43500 ENSMUST00000201067.2 Gm43500 (from geneSymbol) ENSMUST00000201067.1 uc291ann.1 uc291ann.2 uc291ann.1 uc291ann.2 
ENSMUST00000201071.4 Pramel43 ENSMUST00000201071.4 Belongs to the PRAME family. (from UniProt A0A0J9YU88) A0A0J9YU88 A0A0J9YU88_MOUSE BC147369 ENSMUST00000201071.1 ENSMUST00000201071.2 ENSMUST00000201071.3 Pramel43 uc290xfl.1 uc290xfl.2 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xfl.1 uc290xfl.2 
ENSMUST00000201074.2 Gm42737 ENSMUST00000201074.2 Gm42737 (from geneSymbol) AK047532 ENSMUST00000201074.1 uc290wcn.1 uc290wcn.2 uc290wcn.1 uc290wcn.2 
ENSMUST00000201093.2 Gm43151 ENSMUST00000201093.2 Gm43151 (from geneSymbol) ENSMUST00000201093.1 uc291caa.1 uc291caa.2 uc291caa.1 uc291caa.2 
ENSMUST00000201095.2 Gm43068 ENSMUST00000201095.2 Gm43068 (from geneSymbol) AK089649 ENSMUST00000201095.1 uc290zdg.1 uc290zdg.2 uc290zdg.1 uc290zdg.2 
ENSMUST00000201096.2 Gm43051 ENSMUST00000201096.2 Gm43051 (from geneSymbol) ENSMUST00000201096.1 uc290zaj.1 uc290zaj.2 uc290zaj.1 uc290zaj.2 
ENSMUST00000201100.4 Nsun7 ENSMUST00000201100.4 NOL1/NOP2/Sun domain family, member 7, transcript variant 3 (from RefSeq NM_027602.3) A0A0J9YV71 A0A0J9YV71_MOUSE ENSMUST00000201100.1 ENSMUST00000201100.2 ENSMUST00000201100.3 NM_027602 Nsun7 uc290vzg.1 uc290vzg.2 This gene encodes a member of the NOL1/NOP2/sun domain RNA methyltransferase family. Mice with a mutation in this gene exhibit male sterility due to impaired sperm motility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]. Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. Lacks conserved residue(s) required for the propagation of feature annotation. RNA binding methyltransferase activity transferase activity methylation uc290vzg.1 uc290vzg.2 
ENSMUST00000201101.3 Gm36447 ENSMUST00000201101.3 Gm36447 (from geneSymbol) AK136043 ENSMUST00000201101.1 ENSMUST00000201101.2 uc291cdm.1 uc291cdm.2 uc291cdm.3 uc291cdm.1 uc291cdm.2 uc291cdm.3 
ENSMUST00000201115.2 3110031N09Rik ENSMUST00000201115.2 3110031N09Rik (from geneSymbol) AK014107 ENSMUST00000201115.1 uc290wdw.1 uc290wdw.2 uc290wdw.1 uc290wdw.2 
ENSMUST00000201125.4 Abhd1 ENSMUST00000201125.4 abhydrolase domain containing 1, transcript variant 1, noncoding (from RefSeq NR_003522.1) ENSMUST00000201125.1 ENSMUST00000201125.2 ENSMUST00000201125.3 NR_003522 uc057llu.1 uc057llu.2 uc057llu.3 uc057llu.1 uc057llu.2 uc057llu.3 
ENSMUST00000201126.2 Gm19649 ENSMUST00000201126.2 Gm19649 (from geneSymbol) AK080346 ENSMUST00000201126.1 uc290xaa.1 uc290xaa.2 uc290xaa.1 uc290xaa.2 
ENSMUST00000201128.4 D5Ertd605e ENSMUST00000201128.4 DNA segment, Chr 5, ERATO Doi 605, expressed (from RefSeq NR_033625.2) ENSMUST00000201128.1 ENSMUST00000201128.2 ENSMUST00000201128.3 NR_033625 uc009aoc.1 uc009aoc.2 uc009aoc.3 uc009aoc.4 uc009aoc.5 uc009aoc.1 uc009aoc.2 uc009aoc.3 uc009aoc.4 uc009aoc.5 
ENSMUST00000201129.4 Pramel50 ENSMUST00000201129.4 PRAME like 50 (from RefSeq NM_001270457.1) BC061212 ENSMUST00000201129.1 ENSMUST00000201129.2 ENSMUST00000201129.3 Gm7978 NM_001270457 Pramel37 Pramel50 Q6P8K3 Q6P8K3_MOUSE uc008yez.1 uc008yez.2 uc008yez.3 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc008yez.1 uc008yez.2 uc008yez.3 
ENSMUST00000201130.4 Ppef2 ENSMUST00000201130.4 protein phosphatase, EF hand calcium-binding domain 2 (from RefSeq NM_011148.5) ENSMUST00000201130.1 ENSMUST00000201130.2 ENSMUST00000201130.3 NM_011148 O35385 PPE2_MOUSE uc008yco.1 uc008yco.2 uc008yco.3 uc008yco.4 May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission. Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; Activated by calcium. Detected in retina, more specifically in photoreceptors. Belongs to the PPP phosphatase family. phosphoprotein phosphatase activity protein serine/threonine phosphatase activity iron ion binding calcium ion binding nucleus cytosol protein dephosphorylation visual perception negative regulation of peptidyl-threonine phosphorylation hydrolase activity manganese ion binding Hsp70 protein binding mitogen-activated protein kinase kinase kinase binding negative regulation of MAPK cascade metal ion binding response to stimulus detection of stimulus involved in sensory perception Hsp90 protein binding uc008yco.1 uc008yco.2 uc008yco.3 uc008yco.4 
ENSMUST00000201132.3 Or10j7 ENSMUST00000201132.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q8X1) A0A0J9YV77 E9Q8X1 E9Q8X1_MOUSE ENSMUST00000201132.1 ENSMUST00000201132.2 Olfr1406 Or10j7 uc287nzv.1 uc287nzv.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287nzv.1 uc287nzv.2 
ENSMUST00000201136.2 Atraid ENSMUST00000201136.2 Lacks conserved residue(s) required for the propagation of feature annotation. (from UniProt D3Z6U7) AK002276 Atraid D3Z6U7 D3Z6U7_MOUSE ENSMUST00000201136.1 uc290ucx.1 uc290ucx.2 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc290ucx.1 uc290ucx.2 
ENSMUST00000201137.2 Gm43497 ENSMUST00000201137.2 Gm43497 (from geneSymbol) AK053972 ENSMUST00000201137.1 uc287ous.1 uc287ous.2 uc287ous.1 uc287ous.2 
ENSMUST00000201153.2 Gm43594 ENSMUST00000201153.2 Gm43594 (from geneSymbol) ENSMUST00000201153.1 uc290wqs.1 uc290wqs.2 uc290wqs.1 uc290wqs.2 
ENSMUST00000201159.2 Gm42547 ENSMUST00000201159.2 Gm42547 (from geneSymbol) AK034112 ENSMUST00000201159.1 uc291cyo.1 uc291cyo.2 uc291cyo.1 uc291cyo.2 
ENSMUST00000201161.2 Gm9870 ENSMUST00000201161.2 Gm9870 (from geneSymbol) ENSMUST00000201161.1 uc290wgx.1 uc290wgx.2 uc290wgx.1 uc290wgx.2 
ENSMUST00000201166.4 Gckr ENSMUST00000201166.4 glucokinase regulatory protein, transcript variant 1 (from RefSeq NM_001374741.1) A0A0J9YUI8 ENSMUST00000201166.1 ENSMUST00000201166.2 ENSMUST00000201166.3 GCKR_MOUSE Gckr NM_001374741 Q91X44 uc290ugx.1 uc290ugx.2 Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:10713097). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10713097). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (By similarity). Interacts (fructose 6-phosphate bound form) with GCK. Cytoplasm Nucleus Mitochondrion Note=Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus. Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q91X44-2; Sequence=Displayed; Name=1; IsoId=Q91X44-1; Sequence=VSP_061733; Fructose 1-phosphate and fructose 6-phosphate compete for the same binding site. Mice appear normal and are fertile (PubMed:10713097). Their body weights do not differ significantly from the body weights of wild-type animals up to 60 weeks of age (PubMed:10713097). Mice however show a substantial decrease in hepatic glucokinase (Gck) expression and enzymatic activity, with no change in basal blood glucose levels (PubMed:10713097). However, following a glucose tolerance test, mice show impaired glucose clearance, possibly because they cannot recruit sufficient glucokinase due to the absence of a nuclear reserve (PubMed:10713097). Belongs to the GCKR family. cellular glucose homeostasis enzyme inhibitor activity nucleus nucleoplasm cytoplasm mitochondrion cytosol carbohydrate metabolic process protein import into nucleus response to fructose enzyme binding protein domain specific binding carbohydrate binding negative regulation of glucokinase activity positive regulation of glucokinase activity protein localization to nucleus glucose homeostasis urate metabolic process fructose-6-phosphate binding triglyceride homeostasis carbohydrate derivative binding carbohydrate derivative metabolic process negative regulation of hexokinase activity uc290ugx.1 uc290ugx.2 
ENSMUST00000201168.4 Agbl5 ENSMUST00000201168.4 Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins (PubMed:21074048, PubMed:20519502, PubMed:24022482, PubMed:26829768). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:21074048, PubMed:20519502, PubMed:24022482). Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate (PubMed:21074048, PubMed:24022482). Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin (PubMed:24022482). Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (PubMed:26829768). (from UniProt Q09M02) Agbl5 BC057349 CBPC5_MOUSE Ccp5 D3Z6S8 ENSMUST00000201168.1 ENSMUST00000201168.2 ENSMUST00000201168.3 Q09M01 Q09M02 Q09M03 Q09M04 Q6PFZ3 Q8BLL9 Q8BM52 Q8BZD8 Q8C0W4 uc290ubk.1 uc290ubk.2 Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins (PubMed:21074048, PubMed:20519502, PubMed:24022482, PubMed:26829768). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:21074048, PubMed:20519502, PubMed:24022482). Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate (PubMed:21074048, PubMed:24022482). Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin (PubMed:24022482). Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (PubMed:26829768). Reaction=gamma-L-glutamyl-L-glutamyl-[protein] + H2O = L-glutamate + L- glutamyl-[protein]; Xref=Rhea:RHEA:60152, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15517, ChEBI:CHEBI:15377, ChEBI:CHEBI:29973, ChEBI:CHEBI:29985, ChEBI:CHEBI:143622; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60153; Evidence=; Reaction=(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L- glutamate; Xref=Rhea:RHEA:60004, Rhea:RHEA-COMP:15519, Rhea:RHEA- COMP:15675, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:143623; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60005; Evidence=; Reaction=C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O = C- terminal L-alpha-aminoacyl-[tubulin] + L-glutamate; Xref=Rhea:RHEA:63796, Rhea:RHEA-COMP:16436, Rhea:RHEA-COMP:16437, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:90782, ChEBI:CHEBI:149556; EC=3.4.17.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63797; Evidence=; Reaction=C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L- glutamate; Xref=Rhea:RHEA:63792, Rhea:RHEA-COMP:16435, Rhea:RHEA- COMP:16436, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:149555, ChEBI:CHEBI:149556; EC=3.4.17.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63793; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Cytoplasm, cytosol cleus Cytoplasm, cytoskeleton, spindle Midbody Note=Colocalizes with alpha- tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis (By similarity). Mainly cytoplasmic. Slight accumulation in the nucleus is observed (PubMed:17244818). Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q09M02-1; Sequence=Displayed; Name=2; IsoId=Q09M02-2; Sequence=VSP_040433; Name=3; IsoId=Q09M02-3; Sequence=VSP_040432; Name=4; IsoId=Q09M02-4; Sequence=VSP_040434; Name=5; IsoId=Q09M02-5; Sequence=VSP_040427, VSP_040428, VSP_040429, VSP_040430; Name=6; IsoId=Q09M02-6; Sequence=VSP_040431; Name=7; IsoId=Q09M02-7; Sequence=VSP_040428, VSP_040433; Widely expressed. Highly expressed in testis, and moderately in pituitary, brain, eye and kidney. Mice are more vulnerable to DNA virus infection due to impaired immune response. Belongs to the peptidase M14 family. Sequence=AAH57349.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; carboxypeptidase activity metallocarboxypeptidase activity nucleus cytoplasm spindle cytosol cytoskeleton proteolysis peptidase activity metallopeptidase activity zinc ion binding microtubule cytoskeleton tubulin binding hydrolase activity midbody protein deglutamylation protein side chain deglutamylation protein branching point deglutamylation intercellular bridge metal ion binding defense response to virus mitotic spindle uc290ubk.1 uc290ubk.2 
ENSMUST00000201184.2 Ucn ENSMUST00000201184.2 urocortin, transcript variant 2 (from RefSeq NM_001346010.1) ENSMUST00000201184.1 NM_001346010 O88390 P81615 Q14A76 UCN1_MOUSE uc290udv.1 uc290udv.2 This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit a heightened anxiety-like behaviors and a significantly reduced acoustic startle response. [provided by RefSeq, Sep 2016]. Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (By similarity). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (By similarity). Plays a role in the establishment of normal hearing thresholds (PubMed:12091910). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity). Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain). Secreted. In the organ of Corti, detected in the inner hair cell region (at protein level) (PubMed:12091910). Expressed in skin (at protein level) (PubMed:10690896). In skin, levels decrease gradually from the telogen (resting) phase of the hair follicle with lowest levels observed in late anagen IV phase of active growth (at protein level). Increased anxiety-like behavior, reduced Crhr2 mRNA levels in the lateral septum, normal basal feeding behavior, and hearing impairment at the level of the inner ear with shorter outer hair cells, higher threshold for auditory stimuli and higher distortion product otoacoustic emissions. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. G-protein coupled receptor binding positive regulation of protein phosphorylation startle response hormone activity extracellular region inflammatory response response to oxidative stress neuropeptide signaling pathway female pregnancy sensory perception of sound learning or memory feeding behavior associative learning aerobic respiration positive regulation of gene expression negative regulation of gene expression response to auditory stimulus pancreatic juice secretion positive regulation of cell growth axon dendrite negative regulation of histone deacetylation neuron projection development negative regulation of appetite response to estradiol positive regulation of interleukin-6 production positive regulation of collagen biosynthetic process positive regulation of peptidyl-serine phosphorylation activation of protein kinase A activity social behavior gastric emptying drinking behavior neuronal cell body negative regulation of apoptotic process positive regulation of vascular permeability varicosity perikaryon axon terminus positive regulation of cAMP-mediated signaling positive regulation of translation positive regulation of DNA replication negative regulation of blood pressure negative regulation of cell size positive regulation of transcription from RNA polymerase II promoter histone deacetylase inhibitor activity negative regulation of hormone secretion response to pain response to glucocorticoid corticotropin-releasing hormone receptor 1 binding corticotropin-releasing hormone receptor 2 binding positive regulation of corticotropin secretion regulation of synaptic transmission, glutamatergic positive regulation of cardiac muscle contraction negative regulation of gastric acid secretion negative regulation of necrotic cell death negative regulation of cell death positive regulation of calcium ion import negative regulation of neuron death negative regulation of feeding behavior positive regulation of behavioral fear response response to immobilization stress response to starvation prepulse inhibition uc290udv.1 uc290udv.2 
ENSMUST00000201185.4 Gsn ENSMUST00000201185.4 gelsolin, transcript variant 7 (from RefSeq NM_001362948.1) ENSMUST00000201185.1 ENSMUST00000201185.2 ENSMUST00000201185.3 Gsn NM_001362948 Q6PAC1 Q6PAC1_MOUSE uc008jkc.1 uc008jkc.2 uc008jkc.3 uc008jkc.4 Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X. Interacts with the inactive form of EIF2AK2/PKR. Cytoplasm, cytoskeleton Belongs to the villin/gelsolin family. calcium ion binding extracellular region cytosol actin filament polymerization actin nucleation actin filament severing actin filament binding barbed-end actin filament capping uc008jkc.1 uc008jkc.2 uc008jkc.3 uc008jkc.4 
ENSMUST00000201187.2 Gm42507 ENSMUST00000201187.2 Gm42507 (from geneSymbol) ENSMUST00000201187.1 uc290uww.1 uc290uww.2 uc290uww.1 uc290uww.2 
ENSMUST00000201197.2 Gm42571 ENSMUST00000201197.2 Gm42571 (from geneSymbol) ENSMUST00000201197.1 uc290whz.1 uc290whz.2 uc290whz.1 uc290whz.2 
ENSMUST00000201201.2 Gm43480 ENSMUST00000201201.2 Gm43480 (from geneSymbol) ENSMUST00000201201.1 uc291ajy.1 uc291ajy.2 uc291ajy.1 uc291ajy.2 
ENSMUST00000201203.4 Tmem214 ENSMUST00000201203.4 transmembrane protein 214 (from RefSeq NM_144525.4) ENSMUST00000201203.1 ENSMUST00000201203.2 ENSMUST00000201203.3 NM_144525 Q3TLH3 Q3UPX9 Q78HK3 Q8BM55 Q8R0D5 Q8R237 Q8VC05 TM214_MOUSE uc008wwa.1 uc008wwa.2 uc008wwa.3 Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress (By similarity). Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BM55-1; Sequence=Displayed; Name=2; IsoId=Q8BM55-2; Sequence=VSP_031817; Name=3; IsoId=Q8BM55-3; Sequence=VSP_031816; Belongs to the TMEM214 family. Sequence=AAH22142.1; Type=Erroneous initiation; Evidence=; Sequence=AAH26651.1; Type=Erroneous initiation; Evidence=; molecular_function endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol cytoplasmic microtubule apoptotic process biological_process membrane integral component of membrane uc008wwa.1 uc008wwa.2 uc008wwa.3 
ENSMUST00000201213.2 Gm43690 ENSMUST00000201213.2 Gm43690 (from geneSymbol) AK204618 ENSMUST00000201213.1 uc291cco.1 uc291cco.2 uc291cco.1 uc291cco.2 
ENSMUST00000201216.2 Gm42560 ENSMUST00000201216.2 Gm42560 (from geneSymbol) AK145330 ENSMUST00000201216.1 uc290usr.1 uc290usr.2 uc290usr.1 uc290usr.2 
ENSMUST00000201220.2 1700008H02Rik ENSMUST00000201220.2 1700008H02Rik (from geneSymbol) AK005767 ENSMUST00000201220.1 uc290wrp.1 uc290wrp.2 uc290wrp.1 uc290wrp.2 
ENSMUST00000201237.2 Gm43129 ENSMUST00000201237.2 Gm43129 (from geneSymbol) ENSMUST00000201237.1 uc291ces.1 uc291ces.2 uc291ces.1 uc291ces.2 
ENSMUST00000201249.2 Gm42896 ENSMUST00000201249.2 Gm42896 (from geneSymbol) ENSMUST00000201249.1 uc291agk.1 uc291agk.2 uc291agk.1 uc291agk.2 
ENSMUST00000201257.3 Gm17768 ENSMUST00000201257.3 Gm17768 (from geneSymbol) ENSMUST00000201257.1 ENSMUST00000201257.2 uc291oyk.1 uc291oyk.2 uc291oyk.3 uc291oyk.1 uc291oyk.2 uc291oyk.3 
ENSMUST00000201262.2 Gm42854 ENSMUST00000201262.2 Gm42854 (from geneSymbol) AK050700 ENSMUST00000201262.1 uc008zfe.1 uc008zfe.2 uc008zfe.1 uc008zfe.2 
ENSMUST00000201268.2 Gm42790 ENSMUST00000201268.2 Gm42790 (from geneSymbol) AK134653 ENSMUST00000201268.1 uc291aef.1 uc291aef.2 uc291aef.1 uc291aef.2 
ENSMUST00000201272.2 Gm42733 ENSMUST00000201272.2 Gm42733 (from geneSymbol) BC114385 ENSMUST00000201272.1 uc290wij.1 uc290wij.2 uc290wij.1 uc290wij.2 
ENSMUST00000201273.2 Gm42853 ENSMUST00000201273.2 Gm42853 (from geneSymbol) AK148908 ENSMUST00000201273.1 uc290yxc.1 uc290yxc.2 uc290yxc.1 uc290yxc.2 
ENSMUST00000201281.2 2210412B16Rik ENSMUST00000201281.2 2210412B16Rik (from geneSymbol) AK008905 ENSMUST00000201281.1 uc291afe.1 uc291afe.2 uc291afe.1 uc291afe.2 
ENSMUST00000201286.4 AU041133 ENSMUST00000201286.4 expressed sequence AU041133 (from RefSeq NM_001163064.2) A0A0J9YVH3 A0A0J9YVH3_MOUSE AU041133 ENSMUST00000201286.1 ENSMUST00000201286.2 ENSMUST00000201286.3 NM_001163064 uc007gjk.1 uc007gjk.2 uc007gjk.3 May be involved in transcriptional regulation. nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated biological_process sequence-specific DNA binding metal ion binding uc007gjk.1 uc007gjk.2 uc007gjk.3 
ENSMUST00000201293.2 A930005G22Rik ENSMUST00000201293.2 A930005G22Rik (from geneSymbol) ENSMUST00000201293.1 LF195122 uc290ytr.1 uc290ytr.2 uc290ytr.1 uc290ytr.2 
ENSMUST00000201297.2 Becn2 ENSMUST00000201297.2 beclin 2 (from RefSeq NM_001290692.1) BECN2_MOUSE Becn2 ENSMUST00000201297.1 NM_001290692 P0DM65 S5WDD2 uc033fof.1 uc033fof.2 uc033fof.3 Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1. Homodimer (via coiled-coil domain) (By similarity). Interacts (via coiled-coil domain) with ATG14 (via coiled-coil domain); this interaction is tighter than BECN2 self-association (PubMed:23954414). Interacts with AMBRA1, UVRAG and PIK3C3/VPS34; these interactions are not disrupted by starvation (PubMed:23954414). Does not interact with RUBCN. Interacts (via N-terminus) with GPRASP1/GASP1; the interaction is direct (PubMed:23954414). Cytoplasm Expressed in brain, skeletal muscle, placenta, thymus and uterus. Expressed at a lower level in liver, testis, stomach, and 17-day-old embryos. Decreased embryonic viability: embryonic and postnatal survival rates of homozygous mutant mice are markedly lower. Heterozygous knockout mice show defects in autophagy, increased levels of Cnr1 receptor, elevated food intake, and obesity and insulin resistance. Belongs to the beclin family. autophagosome assembly pre-autophagosomal structure protein binding cytoplasm autophagy cellular response to nitrogen starvation endosome to lysosome transport extrinsic component of membrane CVT pathway phosphatidylinositol 3-kinase complex, class III, type I phosphatidylinositol 3-kinase complex, class III, type II glucose homeostasis macromolecular complex binding late endosome to vacuole transport G-protein coupled receptor catabolic process uc033fof.1 uc033fof.2 uc033fof.3 
ENSMUST00000201308.2 Gm42599 ENSMUST00000201308.2 Gm42599 (from geneSymbol) ENSMUST00000201308.1 uc290wke.1 uc290wke.2 uc290wke.1 uc290wke.2 
ENSMUST00000201312.2 Gm43699 ENSMUST00000201312.2 Gm43699 (from geneSymbol) ENSMUST00000201312.1 uc290vdk.1 uc290vdk.2 uc290vdk.1 uc290vdk.2 
ENSMUST00000201316.4 Tmem270 ENSMUST00000201316.4 transmembrane protein 270, transcript variant 1 (from RefSeq NM_194065.3) ENSMUST00000201316.1 ENSMUST00000201316.2 ENSMUST00000201316.3 NM_194065 Q6UJB9 Q9D9B5 TM270_MOUSE Tmem270 Wbscr28 uc008zww.1 uc008zww.2 uc008zww.3 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A; IsoId=Q6UJB9-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q6UJB9-2; Sequence=VSP_028980; Testis. molecular_function cellular_component biological_process membrane integral component of membrane uc008zww.1 uc008zww.2 uc008zww.3 
ENSMUST00000201317.2 Gm42781 ENSMUST00000201317.2 Gm42781 (from geneSymbol) ENSMUST00000201317.1 uc290euv.1 uc290euv.2 uc290euv.1 uc290euv.2 
ENSMUST00000201318.2 5330437M03Rik ENSMUST00000201318.2 5330437M03Rik (from geneSymbol) AK030605 ENSMUST00000201318.1 uc291cva.1 uc291cva.2 uc291cva.1 uc291cva.2 
ENSMUST00000201324.2 Gm20756 ENSMUST00000201324.2 predicted gene, 20756 (from RefSeq NR_040771.1) ENSMUST00000201324.1 NR_040771 uc009bch.1 uc009bch.2 uc009bch.1 uc009bch.2 
ENSMUST00000201325.3 Gm42851 ENSMUST00000201325.3 Gm42851 (from geneSymbol) ENSMUST00000201325.1 ENSMUST00000201325.2 uc290upk.1 uc290upk.2 uc290upk.3 uc290upk.1 uc290upk.2 uc290upk.3 
ENSMUST00000201332.5 U90926 ENSMUST00000201332.5 cDNA sequence U90926 (from RefSeq NM_001416553.1) ENSMUST00000201332.1 ENSMUST00000201332.2 ENSMUST00000201332.3 ENSMUST00000201332.4 NM_001416553 O08546 U90926 U9ORF_MOUSE uc012dyn.1 uc012dyn.2 uc012dyn.3 uc012dyn.4 Plays a protective role during endotoxic shock. Secreted Expressed at highest levels in lipopolysaccharide (LPS)-stimulated bone marrow-derived macrophages and thioglycolate- elicited peritoneal macrophages with minimal expression in other tissues at steady state. Induced in macrophages and dendritic cells by TLR activation in a Myd88- and Mapk14-dependent manner. Glycosylated. Following high LPS dosage to induce severe endotoxemia, knockout mice display significantly sustained sickness responses and reduced survival of 33% in contrast to wild-type mice which show acute clinical signs that peak at 12 hours followed by recovery and survival in 86% of cases (PubMed:36705532). IL6 levels remain elevated at a significantly higher level in knockout mice at 24 hours compared to wild-type mice where levels peak at 4 hours (PubMed:36705532). Minimal intrinsic effects on macrophage function (PubMed:36705532). Sequence=AAB81542.1; Type=Frameshift; Evidence=; uc012dyn.1 uc012dyn.2 uc012dyn.3 uc012dyn.4 
ENSMUST00000201334.2 Gm43418 ENSMUST00000201334.2 Gm43418 (from geneSymbol) BC116285 ENSMUST00000201334.1 uc291agg.1 uc291agg.2 uc291agg.1 uc291agg.2 
ENSMUST00000201340.2 Gm42741 ENSMUST00000201340.2 Gm42741 (from geneSymbol) AK076314 ENSMUST00000201340.1 uc291jef.1 uc291jef.2 uc291jef.1 uc291jef.2 
ENSMUST00000201350.3 1700018A23Rik ENSMUST00000201350.3 1700018A23Rik (from geneSymbol) AK006078 ENSMUST00000201350.1 ENSMUST00000201350.2 uc291jch.1 uc291jch.2 uc291jch.3 uc291jch.1 uc291jch.2 uc291jch.3 
ENSMUST00000201351.4 9130230L23Rik ENSMUST00000201351.4 RIKEN cDNA 9130230L23 gene (from RefSeq NR_027961.1) ENSMUST00000201351.1 ENSMUST00000201351.2 ENSMUST00000201351.3 NR_027961 uc008xoi.1 uc008xoi.2 uc008xoi.3 uc008xoi.4 uc008xoi.1 uc008xoi.2 uc008xoi.3 uc008xoi.4 
ENSMUST00000201352.4 Babam2 ENSMUST00000201352.4 BRISC and BRCA1 A complex member 2, transcript variant 5 (from RefSeq NM_144541.1) BABA2_MOUSE Bre ENSMUST00000201352.1 ENSMUST00000201352.2 ENSMUST00000201352.3 NM_144541 Q497G6 Q6P8Z2 Q8BKU1 Q8CJ13 Q8JZP0 Q8K3V9 Q8K3W0 Q8VHN1 uc008wzf.1 uc008wzf.2 uc008wzf.3 Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1- BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys- 63'-linked ubiquitin (By similarity). May regulate TNF-alpha signaling through its interactions with TNFRSF1A. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1- BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins (By similarity). May also act as a death receptor- associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:9737713). Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1, BRCC3/BRCC36 and BABAM1/NBA1. Binds polyubiquitin. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BRCC3/BRCC36 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. May interact with FAS and TNFRSF1A (PubMed:9737713). Cytoplasm Nucleus Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms may exist. ; Name=2 ; IsoId=Q8K3W0-2; Sequence=Displayed; Name=1 ; Synonyms=I ; IsoId=Q8K3W0-1; Sequence=VSP_051953; Name=3; Synonyms=II, II3+; IsoId=Q8K3W0-4; Sequence=VSP_051952; Name=4; Synonyms=IV; IsoId=Q8K3W0-5; Sequence=VSP_037263; Name=5; Synonyms=III; IsoId=Q8K3W0-6; Sequence=VSP_037262; Expressed in brain, heart, kidney, liver, lung, testis, germinal center B-cells and various mouse cell lines. Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin (By similarity). Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin. Belongs to the BABAM2 family. Sequence=BAC34385.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; nuclear ubiquitin ligase complex tumor necrosis factor receptor binding nucleus cytoplasm cytosol DNA repair double-strand break repair chromatin organization apoptotic process cellular response to DNA damage stimulus cell cycle response to ionizing radiation polyubiquitin binding negative regulation of apoptotic process positive regulation of DNA repair cell division BRCA1-A complex BRISC complex signal transduction involved in G2 DNA damage checkpoint uc008wzf.1 uc008wzf.2 uc008wzf.3 
ENSMUST00000201355.4 Slc23a4 ENSMUST00000201355.4 Membrane ; Multi- pass membrane protein (from UniProt A0A0J9YUX7) 2010107G12Rik A0A0J9YUX7 A0A0J9YUX7_MOUSE BC075651 ENSMUST00000201355.1 ENSMUST00000201355.2 ENSMUST00000201355.3 Slc23a4 uc291dmw.1 uc291dmw.2 Membrane ; Multi- pass membrane protein Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. cellular_component biological_process membrane integral component of membrane transmembrane transporter activity transmembrane transport uc291dmw.1 uc291dmw.2 
ENSMUST00000201364.4 Specc1 ENSMUST00000201364.4 sperm antigen with calponin homology and coiled-coil domains 1, transcript variant 1 (from RefSeq NM_001281818.1) A0A0J9YTU3 A0A0J9YTU3_MOUSE ENSMUST00000201364.1 ENSMUST00000201364.2 ENSMUST00000201364.3 NM_001281818 Specc1 uc287yvg.1 uc287yvg.2 uc287yvg.1 uc287yvg.2 
ENSMUST00000201366.2 4930478M09Rik ENSMUST00000201366.2 4930478M09Rik (from geneSymbol) AK015588 ENSMUST00000201366.1 uc290uhf.1 uc290uhf.2 uc290uhf.1 uc290uhf.2 
ENSMUST00000201367.2 Gm42577 ENSMUST00000201367.2 Gm42577 (from geneSymbol) BC052095 ENSMUST00000201367.1 uc290wlf.1 uc290wlf.2 uc290wlf.1 uc290wlf.2 
ENSMUST00000201397.2 Gm42556 ENSMUST00000201397.2 Gm42556 (from geneSymbol) ENSMUST00000201397.1 uc291cbm.1 uc291cbm.2 uc291cbm.1 uc291cbm.2 
ENSMUST00000201398.2 Gm43313 ENSMUST00000201398.2 Gm43313 (from geneSymbol) ENSMUST00000201398.1 uc290ukb.1 uc290ukb.2 uc290ukb.1 uc290ukb.2 
ENSMUST00000201400.4 Pramel36 ENSMUST00000201400.4 Belongs to the PRAME family. (from UniProt J3QMM8) ENSMUST00000201400.1 ENSMUST00000201400.2 ENSMUST00000201400.3 Gm16429 Gm7971 J3QMM8 J3QMM8_MOUSE L7N204 Pramel36 Pramel49 uc290xex.1 uc290xex.2 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xex.1 uc290xex.2 
ENSMUST00000201403.2 4921513H07Rik ENSMUST00000201403.2 4921513H07Rik (from geneSymbol) AK014881 ENSMUST00000201403.1 uc291jeg.1 uc291jeg.2 uc291jeg.1 uc291jeg.2 
ENSMUST00000201412.2 Gm43747 ENSMUST00000201412.2 Gm43747 (from geneSymbol) AK035635 ENSMUST00000201412.1 uc290wkr.1 uc290wkr.2 uc290wkr.1 uc290wkr.2 
ENSMUST00000201414.5 Cct6a ENSMUST00000201414.5 chaperonin containing TCP1 subunit 6A (from RefSeq NM_009838.3) Cct6a ENSMUST00000201414.1 ENSMUST00000201414.2 ENSMUST00000201414.3 ENSMUST00000201414.4 NM_009838 Q52KG9 Q52KG9_MOUSE uc291ado.1 uc291ado.2 Cytoplasm Belongs to the TCP-1 chaperonin family. nucleotide binding ATP binding cytoplasm protein folding unfolded protein binding uc291ado.1 uc291ado.2 
ENSMUST00000201433.4 Dnm1 ENSMUST00000201433.4 dynamin 1, transcript variant 4 (from RefSeq NM_001368679.1) A0A0J9YUN4 A0A0J9YUN4_MOUSE Dnm1 ENSMUST00000201433.1 ENSMUST00000201433.2 ENSMUST00000201433.3 NM_001368679 uc289vbb.1 uc289vbb.2 This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5; Evidence=; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. nucleotide binding GTPase activity GTP binding uc289vbb.1 uc289vbb.2 
ENSMUST00000201443.3 Gm29926 ENSMUST00000201443.3 Gm29926 (from geneSymbol) ENSMUST00000201443.1 ENSMUST00000201443.2 uc290yxg.1 uc290yxg.2 uc290yxg.3 uc290yxg.1 uc290yxg.2 uc290yxg.3 
ENSMUST00000201451.2 Gm43052 ENSMUST00000201451.2 Gm43052 (from geneSymbol) ENSMUST00000201451.1 uc290zai.1 uc290zai.2 uc290zai.1 uc290zai.2 
ENSMUST00000201452.4 Hsph1 ENSMUST00000201452.4 Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (PubMed:14644449, PubMed:15292236). (from UniProt Q61699) AK083179 ENSMUST00000201452.1 ENSMUST00000201452.2 ENSMUST00000201452.3 HS105_MOUSE Hsp105 Hsp110 Kiaa0201 Q3TNS2 Q3UIY8 Q61699 Q62578 Q62579 Q6A0A5 Q8C430 Q8VCW6 uc291can.1 uc291can.2 Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (PubMed:14644449, PubMed:15292236). Interacts with HSPA8/HSC70 (PubMed:15292236, PubMed:9675148). Interacts with HSPA1A (via NBD) and HSPA1B (via NBD) (By similarity). Cytoplasm Nucleus Note=Strictly cytoplasmic in neurons. Event=Alternative splicing; Named isoforms=2; Name=HSP105-alpha; IsoId=Q61699-1; Sequence=Displayed; Name=HSP105-beta; IsoId=Q61699-2; Sequence=VSP_002429; Expressed in neurons in the cerebrum and Purkinje cells in the cerebellum (at protein level) (PubMed:16232202, PubMed:10865058). Expressed in testis and no expression or only low- level expression in liver, spleen, lung, and kidney (at protein level) (PubMed:16232202). Highly expressed in the brain and moderately expressed in lung, heart, thymus, spleen, liver, and small intestine (PubMed:8530361). By heat shock. [Isoform HSP105-alpha]: Up-regulated by stresses such as treatment with arsenite or amino acid analogs. Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. There is sufficient sequence similarity to other members of the heat shock protein 70 family that some polyclonal antibodies raised against the HSPH1 protein may recognize other epitopes and so expression studies should be interpreted with caution (Probable). Some papers report high level expression in testis (at protein level) (PubMed:16232202). However, others do not detect expression in testis (at transcript level) (PubMed:8530361). Belongs to the heat shock protein 70 family. nucleotide binding adenyl-nucleotide exchange factor activity protein binding ATP binding extracellular region nucleus nucleoplasm cytoplasm cytosol response to unfolded protein macromolecular complex alpha-tubulin binding negative regulation of neuron apoptotic process positive regulation of MHC class I biosynthetic process positive regulation of transcription from RNA polymerase II promoter regulation of catalytic activity chaperone mediated protein folding requiring cofactor positive regulation of NK T cell activation positive regulation of protein tyrosine kinase activity regulation of microtubule cytoskeleton organization negative regulation of establishment of protein localization to mitochondrion negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of p38MAPK cascade negative regulation of apoptotic signaling pathway microtubule uc291can.1 uc291can.2 
ENSMUST00000201457.2 Gm42471 ENSMUST00000201457.2 Gm42471 (from geneSymbol) ENSMUST00000201457.1 uc290ywa.1 uc290ywa.2 uc290ywa.1 uc290ywa.2 
ENSMUST00000201477.2 Gm42848 ENSMUST00000201477.2 Gm42848 (from geneSymbol) AK054367 ENSMUST00000201477.1 uc290uqf.1 uc290uqf.2 uc290uqf.1 uc290uqf.2 
ENSMUST00000201486.2 Gm42897 ENSMUST00000201486.2 Gm42897 (from geneSymbol) ENSMUST00000201486.1 uc291agj.1 uc291agj.2 uc291agj.1 uc291agj.2 
ENSMUST00000201489.4 N4bp2 ENSMUST00000201489.4 NEDD4 binding protein 2 (from RefSeq NM_001024917.1) ENSMUST00000201489.1 ENSMUST00000201489.2 ENSMUST00000201489.3 F8VQG7 F8VQG7_MOUSE N4bp2 NM_001024917 uc008xoa.1 uc008xoa.2 uc008xoa.3 endonuclease activity protein binding ATP binding cytosol phosphorylation ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity nucleic acid phosphodiester bond hydrolysis uc008xoa.1 uc008xoa.2 uc008xoa.3 
ENSMUST00000201492.2 D130004A15Rik ENSMUST00000201492.2 D130004A15Rik (from geneSymbol) AK051136 ENSMUST00000201492.1 uc290wdj.1 uc290wdj.2 uc290wdj.1 uc290wdj.2 
ENSMUST00000201493.2 Gm43197 ENSMUST00000201493.2 Gm43197 (from geneSymbol) AK041020 ENSMUST00000201493.1 uc291cgj.1 uc291cgj.2 uc291cgj.1 uc291cgj.2 
ENSMUST00000201500.2 Potefam3d ENSMUST00000201500.2 Potefam3d (from geneSymbol) A0A0J9YUH2 A0A0J9YUH2_MOUSE ENSMUST00000201500.1 Gm7697 Potefam3d uc292ako.1 uc292ako.2 molecular_function cellular_component biological_process uc292ako.1 uc292ako.2 
ENSMUST00000201501.2 Gm43636 ENSMUST00000201501.2 Gm43636 (from geneSymbol) ENSMUST00000201501.1 uc291jdo.1 uc291jdo.2 uc291jdo.1 uc291jdo.2 
ENSMUST00000201506.2 Gm42656 ENSMUST00000201506.2 Gm42656 (from geneSymbol) ENSMUST00000201506.1 uc290zdv.1 uc290zdv.2 uc290zdv.1 uc290zdv.2 
ENSMUST00000201510.2 1700017L05Rik ENSMUST00000201510.2 1700017L05Rik (from geneSymbol) ENSMUST00000201510.1 uc290wpt.1 uc290wpt.2 uc290wpt.1 uc290wpt.2 
ENSMUST00000201511.2 Sh3tc1 ENSMUST00000201511.2 SH3 domain and tetratricopeptide repeats 1, transcript variant 2 (from RefSeq NM_001359895.1) ENSMUST00000201511.1 G3X9F6 G3X9F6_MOUSE NM_001359895 Sh3tc1 uc290uva.1 uc290uva.2 molecular_function cellular_component biological_process uc290uva.1 uc290uva.2 
ENSMUST00000201517.4 Gm2762 ENSMUST00000201517.4 predicted gene 2762 (from RefSeq NR_037991.1) ENSMUST00000201517.1 ENSMUST00000201517.2 ENSMUST00000201517.3 NR_037991 uc007qnm.1 uc007qnm.2 uc007qnm.3 uc007qnm.1 uc007qnm.2 uc007qnm.3 
ENSMUST00000201519.2 Gm43638 ENSMUST00000201519.2 Belongs to the UDP-glycosyltransferase family. (from UniProt A0A0J9YU36) A0A0J9YU36 A0A0J9YU36_MOUSE BC048926 ENSMUST00000201519.1 Gm43638 uc290wuo.1 uc290wuo.2 Belongs to the UDP-glycosyltransferase family. UDP-glycosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring hexosyl groups intracellular membrane-bounded organelle uc290wuo.1 uc290wuo.2 
ENSMUST00000201521.2 Gm43762 ENSMUST00000201521.2 Gm43762 (from geneSymbol) ENSMUST00000201521.1 uc290uzi.1 uc290uzi.2 uc290uzi.1 uc290uzi.2 
ENSMUST00000201536.2 Gm43268 ENSMUST00000201536.2 Gm43268 (from geneSymbol) ENSMUST00000201536.1 uc290vow.1 uc290vow.2 uc290vow.1 uc290vow.2 
ENSMUST00000201539.2 Gm43788 ENSMUST00000201539.2 Gm43788 (from geneSymbol) ENSMUST00000201539.1 uc290zaf.1 uc290zaf.2 uc290zaf.1 uc290zaf.2 
ENSMUST00000201542.2 Gm17130 ENSMUST00000201542.2 Gm17130 (from geneSymbol) AK037207 ENSMUST00000201542.1 uc290ujf.1 uc290ujf.2 uc290ujf.1 uc290ujf.2 
ENSMUST00000201544.4 Rbm47 ENSMUST00000201544.4 Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing. Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules (PubMed:24916387, PubMed:30844405, PubMed:30309881). Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10 (PubMed:29844590). Also involved in the alternative splicing of several genes including TJP1. Binds the pre- mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons, regulating their exclusion and inclusion into mRNAs (By similarity). Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (By similarity). (from UniProt Q91WT8) AK170082 ENSMUST00000201544.1 ENSMUST00000201544.2 ENSMUST00000201544.3 Q3UQC7 Q8BZE8 Q91WT8 RBM47_MOUSE Rbm47 uc008xoo.1 uc008xoo.2 uc008xoo.3 uc008xoo.4 uc008xoo.5 Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing. Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules (PubMed:24916387, PubMed:30844405, PubMed:30309881). Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10 (PubMed:29844590). Also involved in the alternative splicing of several genes including TJP1. Binds the pre- mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons, regulating their exclusion and inclusion into mRNAs (By similarity). Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (By similarity). Homodimer. Interacts with A1CF (PubMed:24916387). Interacts with APOBEC1; form an mRNA editing complex (By similarity). Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91WT8-1; Sequence=Displayed; Name=2; IsoId=Q91WT8-2; Sequence=VSP_028840, VSP_028841; Homozygous knockout mice die before birth. Belongs to the RRM RBM47 family. hematopoietic progenitor cell differentiation nucleic acid binding RNA binding mRNA binding protein binding nucleus cytidine to uridine editing uc008xoo.1 uc008xoo.2 uc008xoo.3 uc008xoo.4 uc008xoo.5 
ENSMUST00000201546.2 Gm43126 ENSMUST00000201546.2 Gm43126 (from geneSymbol) ENSMUST00000201546.1 uc291jdd.1 uc291jdd.2 uc291jdd.1 uc291jdd.2 
ENSMUST00000201548.4 ENSMUSG00000121792 ENSMUST00000201548.4 ENSMUSG00000121792 (from geneSymbol) ENSMUST00000201548.1 ENSMUST00000201548.2 ENSMUST00000201548.3 uc290wiq.1 uc290wiq.2 uc290wiq.3 uc290wiq.4 uc290wiq.1 uc290wiq.2 uc290wiq.3 uc290wiq.4 
ENSMUST00000201552.3 Pramel44 ENSMUST00000201552.3 PRAME like 44 (from RefSeq NM_001378724.1) A0A0J9YUV1 A0A0J9YUV1_MOUSE ENSMUST00000201552.1 ENSMUST00000201552.2 NM_001378724 Pramel44 uc290xfn.1 uc290xfn.2 uc290xfn.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xfn.1 uc290xfn.2 uc290xfn.3 
ENSMUST00000201553.2 Gm42550 ENSMUST00000201553.2 Gm42550 (from geneSymbol) ENSMUST00000201553.1 uc290yyu.1 uc290yyu.2 uc290yyu.1 uc290yyu.2 
ENSMUST00000201555.2 Pramel35 ENSMUST00000201555.2 Belongs to the PRAME family. (from UniProt A0A0J9YU01) A0A0J9YU01 A0A0J9YU01_MOUSE ENSMUST00000201555.1 Pramel35 uc290xew.1 uc290xew.2 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xew.1 uc290xew.2 
ENSMUST00000201573.2 Gm42645 ENSMUST00000201573.2 Gm42645 (from geneSymbol) ENSMUST00000201573.1 uc290vxz.1 uc290vxz.2 uc290vxz.1 uc290vxz.2 
ENSMUST00000201581.2 Gm43681 ENSMUST00000201581.2 Gm43681 (from geneSymbol) AK034915 ENSMUST00000201581.1 uc290xdy.1 uc290xdy.2 uc290xdy.1 uc290xdy.2 
ENSMUST00000201584.2 Gm42546 ENSMUST00000201584.2 Gm42546 (from geneSymbol) DQ540391 ENSMUST00000201584.1 uc290yya.1 uc290yya.2 uc290yya.1 uc290yya.2 
ENSMUST00000201586.2 Gm43417 ENSMUST00000201586.2 Gm43417 (from geneSymbol) ENSMUST00000201586.1 uc290wju.1 uc290wju.2 uc290wju.1 uc290wju.2 
ENSMUST00000201590.2 Gm43363 ENSMUST00000201590.2 Gm43363 (from geneSymbol) ENSMUST00000201590.1 uc290wym.1 uc290wym.2 uc290wym.1 uc290wym.2 
ENSMUST00000201604.2 Gm42788 ENSMUST00000201604.2 predicted gene 42788 (from RefSeq NR_137278.1) ENSMUST00000201604.1 NR_137278 uc009apf.1 uc009apf.2 uc009apf.1 uc009apf.2 
ENSMUST00000201618.2 Gm42986 ENSMUST00000201618.2 Gm42986 (from geneSymbol) ENSMUST00000201618.1 uc291aen.1 uc291aen.2 uc291aen.1 uc291aen.2 
ENSMUST00000201619.3 Gm43263 ENSMUST00000201619.3 Gm43263 (from geneSymbol) ENSMUST00000201619.1 ENSMUST00000201619.2 uc292akn.1 uc292akn.2 uc292akn.3 uc292akn.1 uc292akn.2 uc292akn.3 
ENSMUST00000201629.5 Pramel57 ENSMUST00000201629.5 PRAME like 57, transcript variant 1 (from RefSeq NM_001167793.1) ENSMUST00000201629.1 ENSMUST00000201629.2 ENSMUST00000201629.3 ENSMUST00000201629.4 NM_001167793 Pramel55 Pramel57 Q3UL33 Q3UL33_MOUSE uc012dzg.1 uc012dzg.2 uc012dzg.3 uc012dzg.4 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc012dzg.1 uc012dzg.2 uc012dzg.3 uc012dzg.4 
ENSMUST00000201640.2 Gm43377 ENSMUST00000201640.2 Gm43377 (from geneSymbol) ENSMUST00000201640.1 uc290uug.1 uc290uug.2 uc290uug.1 uc290uug.2 
ENSMUST00000201641.2 Gm20488 ENSMUST00000201641.2 Gm20488 (from geneSymbol) AK030804 ENSMUST00000201641.1 uc291bzs.1 uc291bzs.2 uc291bzs.1 uc291bzs.2 
ENSMUST00000201645.2 Gm43793 ENSMUST00000201645.2 Gm43793 (from geneSymbol) AK087223 ENSMUST00000201645.1 uc290vzq.1 uc290vzq.2 uc290vzq.1 uc290vzq.2 
ENSMUST00000201648.2 Gm42531 ENSMUST00000201648.2 Gm42531 (from geneSymbol) ENSMUST00000201648.1 LF195316 uc291cck.1 uc291cck.2 uc291cck.1 uc291cck.2 
ENSMUST00000201655.2 Gm43312 ENSMUST00000201655.2 Gm43312 (from geneSymbol) ENSMUST00000201655.1 uc290uka.1 uc290uka.2 uc290uka.1 uc290uka.2 
ENSMUST00000201656.2 Gm42734 ENSMUST00000201656.2 Gm42734 (from geneSymbol) BC114985 ENSMUST00000201656.1 uc290wic.1 uc290wic.2 uc290wic.1 uc290wic.2 
ENSMUST00000201663.5 Pramel60 ENSMUST00000201663.5 PRAME like 60 (from RefSeq NM_001200055.1) D3YUJ6 D3YUJ6_MOUSE ENSMUST00000201663.1 ENSMUST00000201663.2 ENSMUST00000201663.3 ENSMUST00000201663.4 NM_001200055 Pramel56 Pramel60 uc290xga.1 uc290xga.2 uc290xga.3 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xga.1 uc290xga.2 uc290xga.3 
ENSMUST00000201682.2 Gm43496 ENSMUST00000201682.2 Gm43496 (from geneSymbol) ENSMUST00000201682.1 uc287out.1 uc287out.2 uc287out.1 uc287out.2 
ENSMUST00000201683.4 Tex26 ENSMUST00000201683.4 testis expressed 26, transcript variant 1 (from RefSeq NM_029464.3) ENSMUST00000201683.1 ENSMUST00000201683.2 ENSMUST00000201683.3 NM_029464 Q0VB26 TEX26_MOUSE uc009apu.1 uc009apu.2 uc009apu.3 uc009apu.4 molecular_function cytoplasm biological_process uc009apu.1 uc009apu.2 uc009apu.3 uc009apu.4 
ENSMUST00000201684.4 Sds ENSMUST00000201684.4 Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169, ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17; (from UniProt Q8VBT2) AK149438 ENSMUST00000201684.1 ENSMUST00000201684.2 ENSMUST00000201684.3 Q8VBT2 SDHL_MOUSE uc290zbx.1 uc290zbx.2 Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169, ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17; Reaction=L-threonine = 2-oxobutanoate + NH4(+); Xref=Rhea:RHEA:22108, ChEBI:CHEBI:16763, ChEBI:CHEBI:28938, ChEBI:CHEBI:57926; EC=4.3.1.19; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Carbohydrate biosynthesis; gluconeogenesis. Homodimer. Cytoplasm Belongs to the serine/threonine dehydratase family. L-serine ammonia-lyase activity L-threonine ammonia-lyase activity cytoplasm mitochondrion cytosol gluconeogenesis cellular amino acid metabolic process L-serine catabolic process threonine catabolic process lyase activity pyridoxal phosphate binding protein homodimerization activity pyruvate biosynthetic process protein dimerization activity uc290zbx.1 uc290zbx.2 
ENSMUST00000201689.2 4930528J11Rik ENSMUST00000201689.2 4930528J11Rik (from geneSymbol) ENSMUST00000201689.1 uc291dcy.1 uc291dcy.2 uc291dcy.1 uc291dcy.2 
ENSMUST00000201703.4 Pramel56 ENSMUST00000201703.4 Belongs to the PRAME family. (from UniProt D3YUJ6) AK145705 D3YUJ6 D3YUJ6_MOUSE ENSMUST00000201703.1 ENSMUST00000201703.2 ENSMUST00000201703.3 Pramel56 Pramel60 uc012dyy.1 uc012dyy.2 uc012dyy.3 Belongs to the PRAME family. molecular_function cellular_component cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc012dyy.1 uc012dyy.2 uc012dyy.3 
ENSMUST00000201707.2 Gm42632 ENSMUST00000201707.2 Gm42632 (from geneSymbol) ENSMUST00000201707.1 LF194982 uc290wcd.1 uc290wcd.2 uc290wcd.1 uc290wcd.2 
ENSMUST00000201715.2 Gm43481 ENSMUST00000201715.2 Gm43481 (from geneSymbol) ENSMUST00000201715.1 uc291ajr.1 uc291ajr.2 uc291ajr.1 uc291ajr.2 
ENSMUST00000201718.2 Gm42735 ENSMUST00000201718.2 Gm42735 (from geneSymbol) AK038003 ENSMUST00000201718.1 uc290wcl.1 uc290wcl.2 uc290wcl.1 uc290wcl.2 
ENSMUST00000201722.2 Litafd ENSMUST00000201722.2 LITAF domain containing (from RefSeq NM_001324517.2) A0A0J9YTU8 A0A0J9YTU8_MOUSE ENSMUST00000201722.1 Gm5767 Litafd NM_001324517 uc007ycu.1 uc007ycu.2 uc007ycu.3 Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the CDIP1/LITAF family. molecular_function cellular_component biological_process membrane integral component of membrane uc007ycu.1 uc007ycu.2 uc007ycu.3 
ENSMUST00000201728.4 1110006O24Rik ENSMUST00000201728.4 RIKEN cDNA 1110006O24 gene (from RefSeq NR_027810.1) ENSMUST00000201728.1 ENSMUST00000201728.2 ENSMUST00000201728.3 NR_027810 uc008zeh.1 uc008zeh.2 uc008zeh.3 uc008zeh.4 uc008zeh.5 uc008zeh.1 uc008zeh.2 uc008zeh.3 uc008zeh.4 uc008zeh.5 
ENSMUST00000201732.2 Gm42847 ENSMUST00000201732.2 Gm42847 (from geneSymbol) AK049635 ENSMUST00000201732.1 uc290upm.1 uc290upm.2 uc290upm.1 uc290upm.2 
ENSMUST00000201734.4 Grep1 ENSMUST00000201734.4 Grep1 (from geneSymbol) 1520401A03Rik A0A0J9YVH6 A0A0J9YVH6_MOUSE AK047830 ENSMUST00000201734.1 ENSMUST00000201734.2 ENSMUST00000201734.3 Grep1 uc289huc.1 uc289huc.2 molecular_function cellular_component biological_process uc289huc.1 uc289huc.2 
ENSMUST00000201742.2 Gm43860 ENSMUST00000201742.2 Gm43860 (from geneSymbol) AK028508 ENSMUST00000201742.1 uc290uui.1 uc290uui.2 uc290uui.1 uc290uui.2 
ENSMUST00000201755.2 6720475M21Rik ENSMUST00000201755.2 6720475M21Rik (from geneSymbol) ENSMUST00000201755.1 uc290wkh.1 uc290wkh.2 uc290wkh.1 uc290wkh.2 
ENSMUST00000201757.2 Gm36669 ENSMUST00000201757.2 predicted gene, 36669 (from RefSeq NR_157239.1) ENSMUST00000201757.1 NR_157239 uc291cqs.1 uc291cqs.2 uc291cqs.1 uc291cqs.2 
ENSMUST00000201761.3 Gm43763 ENSMUST00000201761.3 Gm43763 (from geneSymbol) ENSMUST00000201761.1 ENSMUST00000201761.2 uc290uza.1 uc290uza.2 uc290uza.3 uc290uza.1 uc290uza.2 uc290uza.3 
ENSMUST00000201762.2 Gm43196 ENSMUST00000201762.2 Gm43196 (from geneSymbol) AK138008 ENSMUST00000201762.1 uc291cgg.1 uc291cgg.2 uc291cgg.1 uc291cgg.2 
ENSMUST00000201764.2 Gm43025 ENSMUST00000201764.2 Gm43025 (from geneSymbol) ENSMUST00000201764.1 uc290wde.1 uc290wde.2 uc290wde.1 uc290wde.2 
ENSMUST00000201770.2 Gm42729 ENSMUST00000201770.2 Gm42729 (from geneSymbol) ENSMUST00000201770.1 LF194973 uc290vxg.1 uc290vxg.2 uc290vxg.1 uc290vxg.2 
ENSMUST00000201771.2 Mxd4os1 ENSMUST00000201771.2 Mxd4os1 (from geneSymbol) ENSMUST00000201771.1 uc290uqb.1 uc290uqb.2 uc290uqb.1 uc290uqb.2 
ENSMUST00000201779.2 Mageb2 ENSMUST00000201779.2 MAGE family member B2 (from RefSeq NM_031171.1) ENSMUST00000201779.1 Mageb1 Mageb2 NM_031171 Q4U221 Q4U221_MOUSE uc009tsi.1 uc009tsi.2 uc009tsi.3 molecular_function cellular_component biological_process uc009tsi.1 uc009tsi.2 uc009tsi.3 
ENSMUST00000201784.4 Fkbp6 ENSMUST00000201784.4 FK506 binding protein 6, transcript variant 3 (from RefSeq NM_001277892.2) ENSMUST00000201784.1 ENSMUST00000201784.2 ENSMUST00000201784.3 FKBP6_MOUSE Fkbp36 NM_001277892 Q8C1Y1 Q91VB7 Q91XW8 Q91Y30 uc008zyd.1 uc008zyd.2 uc008zyd.3 This gene is a member of the FK506-binding protein (Fkbp) family. The encoded protein plays a role in male-specific fertility and homologous pairing of chromosomes during meiosis. The protein may also be involved in LINE1 transposon silencing and binding to Hsp90 as a co-chaperone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]. Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by- products from Piwi complexes, possibly facilitating turnover of Piwi complexes. Interacts with HSP72/HSPA2 and CLTC. Interacts with GAPDH; leading to inhibit GAPDH catalytic activity (By similarity). Interacts (via TPR repeats) with HSP90. Cytoplasm, cytosol cleus Chromosome Note=Does not localize to pi- bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (synaptonemal complex). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q91XW8-1; Sequence=Displayed; Name=2; IsoId=Q91XW8-2; Sequence=VSP_005185, VSP_005186; Name=3; IsoId=Q91XW8-3; Sequence=VSP_005185; Testis-specific. Present in spermatocytes. Expression is lost as cells exit prophase I. Not detected in spermatids (at protein level). Males mice are sterile and aspermic due to abnormal pachytene spermatocytes, characterized by the appearance of unusual inclusion bodies and dense compacted nuclei. Spermatocytes fail to proceed beyond the pachytene stage due to abnormal pairing and misalignments between homologous chromosomes, non-homologous partner switches and autosynapsis of X chromosome cores in meiotic spermatocytes. No other abnormalities are detected in any tissues of males. Females mice are fertile (PubMed:12764197). Spermatocytes show derepressed LINE-1 retrotransposon and reduced DNA methylation due to deficient nuclear accumulation of Miwi2 (PubMed:22902560). Belongs to the FKBP6 family. Although it contains a PPIase FKBP-type domain, does not show peptidyl-prolyl cis-trans isomerase activity. protein peptidyl-prolyl isomerization synaptonemal complex nucleus nucleoplasm chromosome cytoplasm cytosol protein folding spermatogenesis cell differentiation gene silencing by RNA piRNA metabolic process identical protein binding DNA methylation involved in gamete generation positive regulation of viral genome replication meiotic cell cycle Hsp90 protein binding peptidyl-prolyl cis-trans isomerase activity uc008zyd.1 uc008zyd.2 uc008zyd.3 
ENSMUST00000201786.4 B3galt9 ENSMUST00000201786.4 beta-1,3-galactosyltransferase 9, transcript variant 2 (from RefSeq NM_001399765.1) A0A1L1SR01 A0A1L1SR01_MOUSE B3galt9 ENSMUST00000201786.1 ENSMUST00000201786.2 ENSMUST00000201786.3 Gm34653 NM_001399765 uc289vkk.1 uc289vkk.2 Golgi apparatus membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 31 family. Golgi membrane endoplasmic reticulum Golgi apparatus protein glycosylation protein O-linked glycosylation acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups poly-N-acetyllactosamine biosynthetic process uc289vkk.1 uc289vkk.2 
ENSMUST00000201793.2 Gm43425 ENSMUST00000201793.2 Gm43425 (from geneSymbol) ENSMUST00000201793.1 uc289ozm.1 uc289ozm.2 uc289ozm.1 uc289ozm.2 
ENSMUST00000201811.2 Gm42559 ENSMUST00000201811.2 Gm42559 (from geneSymbol) AK034578 ENSMUST00000201811.1 uc290uqy.1 uc290uqy.2 uc290uqy.1 uc290uqy.2 
ENSMUST00000201812.2 Gm43229 ENSMUST00000201812.2 Gm43229 (from geneSymbol) ENSMUST00000201812.1 uc290wdo.1 uc290wdo.2 uc290wdo.1 uc290wdo.2 
ENSMUST00000201813.3 Gm42738 ENSMUST00000201813.3 Gm42738 (from geneSymbol) ENSMUST00000201813.1 ENSMUST00000201813.2 uc291jee.1 uc291jee.2 uc291jee.3 uc291jee.1 uc291jee.2 uc291jee.3 
ENSMUST00000201829.2 Gm43029 ENSMUST00000201829.2 Gm43029 (from geneSymbol) ENSMUST00000201829.1 uc291dca.1 uc291dca.2 uc291dca.1 uc291dca.2 
ENSMUST00000201831.4 Gm20559 ENSMUST00000201831.4 Gm20559 (from geneSymbol) AK035387 ENSMUST00000201831.1 ENSMUST00000201831.2 ENSMUST00000201831.3 uc009aux.1 uc009aux.2 uc009aux.3 uc009aux.1 uc009aux.2 uc009aux.3 
ENSMUST00000201839.2 Gm42731 ENSMUST00000201839.2 Gm42731 (from geneSymbol) AK053283 ENSMUST00000201839.1 uc291aos.1 uc291aos.2 uc291aos.1 uc291aos.2 
ENSMUST00000201845.2 Gm43799 ENSMUST00000201845.2 Gm43799 (from geneSymbol) AK080336 ENSMUST00000201845.1 uc290wjg.1 uc290wjg.2 uc290wjg.1 uc290wjg.2 
ENSMUST00000201848.2 Gm43282 ENSMUST00000201848.2 Gm43282 (from geneSymbol) AK143041 ENSMUST00000201848.1 uc290waz.1 uc290waz.2 uc290waz.1 uc290waz.2 
ENSMUST00000201862.2 Gm43588 ENSMUST00000201862.2 Gm43588 (from geneSymbol) ENSMUST00000201862.1 LF195648 uc291gle.1 uc291gle.2 uc291gle.1 uc291gle.2 
ENSMUST00000201865.2 C530043K16Rik ENSMUST00000201865.2 C530043K16Rik (from geneSymbol) ENSMUST00000201865.1 uc290waf.1 uc290waf.2 uc290waf.1 uc290waf.2 
ENSMUST00000201868.2 Gm43800 ENSMUST00000201868.2 Gm43800 (from geneSymbol) AK078276 ENSMUST00000201868.1 uc291dho.1 uc291dho.2 uc291dho.1 uc291dho.2 
ENSMUST00000201871.2 Gm43769 ENSMUST00000201871.2 Gm43769 (from geneSymbol) AB352773 ENSMUST00000201871.1 uc290vye.1 uc290vye.2 uc290vye.1 uc290vye.2 
ENSMUST00000201872.2 Gm43004 ENSMUST00000201872.2 Gm43004 (from geneSymbol) ENSMUST00000201872.1 uc290vyb.1 uc290vyb.2 uc290vyb.1 uc290vyb.2 
ENSMUST00000201873.2 Gm43452 ENSMUST00000201873.2 Gm43452 (from geneSymbol) ENSMUST00000201873.1 uc057bwe.1 uc057bwe.2 uc057bwe.1 uc057bwe.2 
ENSMUST00000201886.3 4930428D20Rik ENSMUST00000201886.3 RIKEN cDNA 4930428D20 gene (from RefSeq NR_130991.1) ENSMUST00000201886.1 ENSMUST00000201886.2 NR_130991 uc056zcq.1 uc056zcq.2 uc056zcq.3 uc056zcq.4 uc056zcq.1 uc056zcq.2 uc056zcq.3 uc056zcq.4 
ENSMUST00000201893.2 Gm43123 ENSMUST00000201893.2 Gm43123 (from geneSymbol) ENSMUST00000201893.1 LF246332 uc291aou.1 uc291aou.2 uc291aou.1 uc291aou.2 
ENSMUST00000201899.2 Gm42761 ENSMUST00000201899.2 Gm42761 (from geneSymbol) ENSMUST00000201899.1 uc290wpu.1 uc290wpu.2 uc290wpu.1 uc290wpu.2 
ENSMUST00000201903.2 1700126H18Rik ENSMUST00000201903.2 RIKEN cDNA 1700126H18 gene (from RefSeq NR_040695.1) ENSMUST00000201903.1 NR_040695 uc008xoq.1 uc008xoq.2 uc008xoq.3 uc008xoq.1 uc008xoq.2 uc008xoq.3 
ENSMUST00000201914.2 Gm42458 ENSMUST00000201914.2 Gm42458 (from geneSymbol) ENSMUST00000201914.1 uc291jdp.1 uc291jdp.2 uc291jdp.1 uc291jdp.2 
ENSMUST00000201916.2 Gm43416 ENSMUST00000201916.2 Gm43416 (from geneSymbol) AK076891 ENSMUST00000201916.1 uc290wjw.1 uc290wjw.2 uc290wjw.1 uc290wjw.2 
ENSMUST00000201933.2 Gm33167 ENSMUST00000201933.2 Gm33167 (from geneSymbol) AK141106 ENSMUST00000201933.1 uc290wbk.1 uc290wbk.2 uc290wbk.1 uc290wbk.2 
ENSMUST00000201934.2 Gm43415 ENSMUST00000201934.2 Gm43415 (from geneSymbol) AK042899 ENSMUST00000201934.1 uc290wjv.1 uc290wjv.2 uc290wjv.1 uc290wjv.2 
ENSMUST00000201941.2 Gm3822 ENSMUST00000201941.2 Gm3822 (from geneSymbol) AK133319 ENSMUST00000201941.1 uc057buk.1 uc057buk.2 uc057buk.1 uc057buk.2 
ENSMUST00000201944.2 C730045M19Rik ENSMUST00000201944.2 C730045M19Rik (from geneSymbol) AK050406 ENSMUST00000201944.1 uc290yrs.1 uc290yrs.2 uc290yrs.1 uc290yrs.2 
ENSMUST00000201946.2 ENSMUSG00000121673 ENSMUST00000201946.2 ENSMUSG00000121673 (from geneSymbol) ENSMUST00000201946.1 uc291bzc.1 uc291bzc.2 uc291bzc.1 uc291bzc.2 
ENSMUST00000201947.2 9430007M09Rik ENSMUST00000201947.2 9430007M09Rik (from geneSymbol) AK020407 ENSMUST00000201947.1 uc291aoc.1 uc291aoc.2 uc291aoc.1 uc291aoc.2 
ENSMUST00000201948.4 Pds5a ENSMUST00000201948.4 PDS5 cohesin associated factor A (from RefSeq NM_001081321.3) E9QPI5 E9QPI5_MOUSE ENSMUST00000201948.1 ENSMUST00000201948.2 ENSMUST00000201948.3 NM_001081321 Pds5a uc290vwy.1 uc290vwy.2 Belongs to the PDS5 family. chromatin nucleoplasm plasma membrane mitotic sister chromatid cohesion negative regulation of DNA replication uc290vwy.1 uc290vwy.2 
ENSMUST00000201951.2 Gm42811 ENSMUST00000201951.2 Gm42811 (from geneSymbol) AK133259 ENSMUST00000201951.1 uc291jeh.1 uc291jeh.2 uc291jeh.1 uc291jeh.2 
ENSMUST00000201966.2 Gm42962 ENSMUST00000201966.2 Gm42962 (from geneSymbol) AK085647 ENSMUST00000201966.1 uc291dqh.1 uc291dqh.2 uc291dqh.1 uc291dqh.2 
ENSMUST00000201971.2 2510016D11Rik ENSMUST00000201971.2 2510016D11Rik (from geneSymbol) ENSMUST00000201971.1 uc290zci.1 uc290zci.2 uc290zci.1 uc290zci.2 
ENSMUST00000201972.2 Bend4 ENSMUST00000201972.2 Bend4 (from geneSymbol) BEND4_MOUSE Bend4 ENSMUST00000201972.1 P86174 uc290wcb.1 uc290wcb.2 molecular_function cellular_component biological_process uc290wcb.1 uc290wcb.2 
ENSMUST00000201992.2 Gm43597 ENSMUST00000201992.2 Gm43597 (from geneSymbol) BC062895 ENSMUST00000201992.1 uc009auf.1 uc009auf.2 uc009auf.1 uc009auf.2 
ENSMUST00000202001.2 Gm43167 ENSMUST00000202001.2 Gm43167 (from geneSymbol) AK041003 ENSMUST00000202001.1 uc290wkj.1 uc290wkj.2 uc290wkj.1 uc290wkj.2 
ENSMUST00000202005.2 Gm38404 ENSMUST00000202005.2 predicted gene, 38404 (from RefSeq NR_073373.1) ENSMUST00000202005.1 NR_073373 uc033ivc.1 uc033ivc.2 uc033ivc.1 uc033ivc.2 
ENSMUST00000202006.4 Myo1h ENSMUST00000202006.4 myosin 1H, transcript variant 1 (from RefSeq NM_001164573.2) A0A0J9YUC4 A0A0J9YUC4_MOUSE ENSMUST00000202006.1 ENSMUST00000202006.2 ENSMUST00000202006.3 Myo1h NM_001164573 uc012ebt.1 uc012ebt.2 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. nucleotide binding motor activity actin binding ATP binding myosin complex uc012ebt.1 uc012ebt.2 
ENSMUST00000202009.2 Gm42506 ENSMUST00000202009.2 Gm42506 (from geneSymbol) ENSMUST00000202009.1 uc290uxg.1 uc290uxg.2 uc290uxg.1 uc290uxg.2 
ENSMUST00000202029.2 Gm13821 ENSMUST00000202029.2 Gm13821 (from geneSymbol) DQ722098 ENSMUST00000202029.1 uc029vmu.1 uc029vmu.2 uc029vmu.3 uc029vmu.1 uc029vmu.2 uc029vmu.3 
ENSMUST00000202033.2 Gm43809 ENSMUST00000202033.2 Gm43809 (from geneSymbol) AK002421 ENSMUST00000202033.1 uc290uio.1 uc290uio.2 uc290uio.1 uc290uio.2 
ENSMUST00000202051.2 Gm43795 ENSMUST00000202051.2 Gm43795 (from geneSymbol) AK049757 ENSMUST00000202051.1 uc290wad.1 uc290wad.2 uc290wad.1 uc290wad.2 
ENSMUST00000202053.2 Gm43275 ENSMUST00000202053.2 Gm43275 (from geneSymbol) AK050595 ENSMUST00000202053.1 uc290zag.1 uc290zag.2 uc290zag.1 uc290zag.2 
ENSMUST00000202056.2 Gm43798 ENSMUST00000202056.2 Gm43798 (from geneSymbol) AK197646 ENSMUST00000202056.1 uc290wiu.1 uc290wiu.2 uc290wiu.1 uc290wiu.2 
ENSMUST00000202066.3 Gm5 ENSMUST00000202066.3 predicted gene 5 (from RefSeq NR_024513.1) ENSMUST00000202066.1 ENSMUST00000202066.2 NR_024513 uc012ehl.1 uc012ehl.2 uc012ehl.3 uc012ehl.4 uc012ehl.1 uc012ehl.2 uc012ehl.3 uc012ehl.4 
ENSMUST00000202073.2 Gm10461 ENSMUST00000202073.2 Gm10461 (from geneSymbol) AK141859 ENSMUST00000202073.1 uc056zzf.1 uc056zzf.2 uc056zzf.3 uc056zzf.4 uc056zzf.5 uc056zzf.1 uc056zzf.2 uc056zzf.3 uc056zzf.4 uc056zzf.5 
ENSMUST00000202075.3 Gm43269 ENSMUST00000202075.3 Gm43269 (from geneSymbol) ENSMUST00000202075.1 ENSMUST00000202075.2 uc290zbf.1 uc290zbf.2 uc290zbf.3 uc290zbf.1 uc290zbf.2 uc290zbf.3 
ENSMUST00000202081.2 Gm42600 ENSMUST00000202081.2 Gm42600 (from geneSymbol) ENSMUST00000202081.1 LF195648 uc291gli.1 uc291gli.2 uc291gli.1 uc291gli.2 
ENSMUST00000202084.2 Gm10829 ENSMUST00000202084.2 Gm10829 (from geneSymbol) ENSMUST00000202084.1 uc289vno.1 uc289vno.2 uc289vno.1 uc289vno.2 
ENSMUST00000202091.2 Gm43499 ENSMUST00000202091.2 Gm43499 (from geneSymbol) AK088873 ENSMUST00000202091.1 uc290wgu.1 uc290wgu.2 uc290wgu.1 uc290wgu.2 
ENSMUST00000202098.2 Gm43852 ENSMUST00000202098.2 Gm43852 (from geneSymbol) AK078320 ENSMUST00000202098.1 uc290ukm.1 uc290ukm.2 uc290ukm.1 uc290ukm.2 
ENSMUST00000202099.2 Gm42466 ENSMUST00000202099.2 Gm42466 (from geneSymbol) ENSMUST00000202099.1 uc290wcw.1 uc290wcw.2 uc290wcw.1 uc290wcw.2 
ENSMUST00000202102.2 Ptprz1 ENSMUST00000202102.2 protein tyrosine phosphatase receptor type Z, polypeptide 1, transcript variant 8 (from RefSeq NM_001403054.1) B2RXS8 B2RXS8_MOUSE ENSMUST00000202102.1 NM_001403054 Ptprz1 uc012eim.1 uc012eim.2 uc012eim.3 Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Membrane ; Single- pass type I membrane protein Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein dephosphorylation membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity peptidyl-tyrosine dephosphorylation uc012eim.1 uc012eim.2 uc012eim.3 
ENSMUST00000202120.2 Gm43760 ENSMUST00000202120.2 Gm43760 (from geneSymbol) AB350508 ENSMUST00000202120.1 uc289vnm.1 uc289vnm.2 uc289vnm.1 uc289vnm.2 
ENSMUST00000202132.2 Gm43761 ENSMUST00000202132.2 Gm43761 (from geneSymbol) AK029406 ENSMUST00000202132.1 uc289vmw.1 uc289vmw.2 uc289vmw.1 uc289vmw.2 
ENSMUST00000202139.2 Gm43172 ENSMUST00000202139.2 Gm43172 (from geneSymbol) ENSMUST00000202139.1 uc290xdp.1 uc290xdp.2 uc290xdp.1 uc290xdp.2 
ENSMUST00000202150.2 Gm43682 ENSMUST00000202150.2 Gm43682 (from geneSymbol) AK043049 ENSMUST00000202150.1 uc290xdw.1 uc290xdw.2 uc290xdw.1 uc290xdw.2 
ENSMUST00000202154.3 Gm40304 ENSMUST00000202154.3 Gm40304 (from geneSymbol) ENSMUST00000202154.1 ENSMUST00000202154.2 uc290vog.1 uc290vog.2 uc290vog.3 uc290vog.1 uc290vog.2 uc290vog.3 
ENSMUST00000202166.2 2900064F13Rik ENSMUST00000202166.2 2900064F13Rik (from geneSymbol) ENSMUST00000202166.1 uc290wro.1 uc290wro.2 uc290wro.1 uc290wro.2 
ENSMUST00000202170.4 Pds5b ENSMUST00000202170.4 PDS5 cohesin associated factor B, transcript variant 2 (from RefSeq NM_001346503.2) Aprin As3 ENSMUST00000202170.1 ENSMUST00000202170.2 ENSMUST00000202170.3 Kiaa0979 NM_001346503 PDS5B_MOUSE Q3TNZ4 Q4VA53 Q7TSS4 Q80TM8 Q8BJ18 Q8BLH6 Q8BX77 uc291cdd.1 uc291cdd.2 Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells (By similarity). Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q4VA53-1; Sequence=Displayed; Name=2 ; IsoId=Q4VA53-2; Sequence=VSP_052403, VSP_052405, VSP_052406; Name=3 ; IsoId=Q4VA53-3; Sequence=VSP_052404; Expressed in prostate. Belongs to the PDS5 family. chromatin lens development in camera-type eye molecular_function DNA binding nucleus nucleoplasm DNA repair cell cycle mitotic sister chromatid cohesion negative regulation of cell proliferation regulation of cell proliferation cell division neuroblast migration uc291cdd.1 uc291cdd.2 
ENSMUST00000202184.2 Gm42959 ENSMUST00000202184.2 Gm42959 (from geneSymbol) AK183415 ENSMUST00000202184.1 uc291cgb.1 uc291cgb.2 uc291cgb.1 uc291cgb.2 
ENSMUST00000202206.2 Gm43637 ENSMUST00000202206.2 Gm43637 (from geneSymbol) ENSMUST00000202206.1 uc290yxp.1 uc290yxp.2 uc290yxp.1 uc290yxp.2 
ENSMUST00000202212.2 Gm43128 ENSMUST00000202212.2 Gm43128 (from geneSymbol) AK143278 ENSMUST00000202212.1 uc289vmm.1 uc289vmm.2 uc289vmm.1 uc289vmm.2 
ENSMUST00000202220.4 Plb1 ENSMUST00000202220.4 Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn- 1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (By similarity). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (By similarity). May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (By similarity). (from UniProt Q3TTY0) AK030142 ENSMUST00000202220.1 ENSMUST00000202220.2 ENSMUST00000202220.3 PLB1_MOUSE Plb Q0VEX7 Q3TTY0 Q9D4Y6 uc290ujp.1 uc290ujp.2 Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn- 1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (By similarity). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (By similarity). May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (By similarity). Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15178; Evidence=; Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12045; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40923, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40924; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn- glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40812; Evidence=; Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40971, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73002, ChEBI:CHEBI:76084; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40972; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn- glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40911, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:73004, ChEBI:CHEBI:73007; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40912; Evidence=; Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'- sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero- 3-phospho-(1'-sn-glycerol) + H(+); Xref=Rhea:RHEA:40919, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72841, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40920; Evidence=; Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40975, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40976; Evidence=; Reaction=1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3- phosphocholine + H(+); Xref=Rhea:RHEA:40915, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:34112, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40916; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence=; Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + di-(9Z)-octadecenoylglycerol + H(+); Xref=Rhea:RHEA:38575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38576; Evidence=; Reaction=1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate; Xref=Rhea:RHEA:41111, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:75466, ChEBI:CHEBI:77623; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41112; Evidence=; Reaction=1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = (9Z)- octadecenoate + 1,3-dihexadecanoylglycerol + H(+); Xref=Rhea:RHEA:40983, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75688, ChEBI:CHEBI:77619; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40984; Evidence=; Reaction=1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1- hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:40979, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:75585, ChEBI:CHEBI:75688; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40980; Evidence=; Reaction=1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn- glycerol + H(+); Xref=Rhea:RHEA:41103, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:77623, ChEBI:CHEBI:77624; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41104; Evidence=; Reaction=1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:41107, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:75558, ChEBI:CHEBI:77623; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41108; Evidence=; Reaction=1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:40927, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:75550, ChEBI:CHEBI:77097; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40928; Evidence=; Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)- octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+); Xref=Rhea:RHEA:41219, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52333, ChEBI:CHEBI:75757; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41220; Evidence=; Reaction=2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)- octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+); Xref=Rhea:RHEA:42604, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75824, ChEBI:CHEBI:75938; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42605; Evidence=; Reaction=1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:39939, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75735, ChEBI:CHEBI:75937; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39940; Evidence=; Reaction=1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38488; Evidence=; Reaction=2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38491, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:73990; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38492; Evidence=; Apical cell membrane ; Single-pass type I membrane protein Note=Present in the intestinal brush border membranes. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3TTY0-1; Sequence=Displayed; Name=2; IsoId=Q3TTY0-2; Sequence=VSP_032235, VSP_032236; Name=3; IsoId=Q3TTY0-3; Sequence=VSP_032237, VSP_032238; Name=4; IsoId=Q3TTY0-4; Sequence=VSP_032233, VSP_032234; Repeat 2 contains the catalytic domain. Undergoes proteolytic cleavage in the ileum. Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily. Sequence=AAI19078.1; Type=Erroneous initiation; Evidence=; phospholipase activity lysophospholipase activity phospholipase A2 activity plasma membrane lipid metabolic process phospholipid metabolic process membrane integral component of membrane lipid catabolic process lipase activity apical plasma membrane hydrolase activity hydrolase activity, acting on ester bonds brush border membrane retinol metabolic process retinyl-palmitate esterase activity positive regulation of acrosome reaction uc290ujp.1 uc290ujp.2 
ENSMUST00000202228.2 9030607J07Rik ENSMUST00000202228.2 9030607J07Rik (from geneSymbol) AK018539 ENSMUST00000202228.1 uc291amc.1 uc291amc.2 uc291amc.1 uc291amc.2 
ENSMUST00000202229.2 Gm15406 ENSMUST00000202229.2 Gm15406 (from geneSymbol) AK079377 ENSMUST00000202229.1 uc291byh.1 uc291byh.2 uc291byh.1 uc291byh.2 
ENSMUST00000202233.2 Gm42646 ENSMUST00000202233.2 Gm42646 (from geneSymbol) ENSMUST00000202233.1 uc290vya.1 uc290vya.2 uc290vya.1 uc290vya.2 
ENSMUST00000202246.3 Gm43173 ENSMUST00000202246.3 Gm43173 (from geneSymbol) ENSMUST00000202246.1 ENSMUST00000202246.2 LF195032 uc290xdq.1 uc290xdq.2 uc290xdq.3 uc290xdq.1 uc290xdq.2 uc290xdq.3 
ENSMUST00000202253.2 Pramel52-ps ENSMUST00000202253.2 PRAME like 52, pseudogene, transcript variant 1 (from RefSeq NR_178070.1) ENSMUST00000202253.1 NR_178070 uc008yel.1 uc008yel.2 uc008yel.3 uc008yel.1 uc008yel.2 uc008yel.3 
ENSMUST00000202259.3 Gm43122 ENSMUST00000202259.3 Gm43122 (from geneSymbol) ENSMUST00000202259.1 ENSMUST00000202259.2 uc290yxf.1 uc290yxf.2 uc290yxf.3 uc290yxf.1 uc290yxf.2 uc290yxf.3 
ENSMUST00000202261.5 Morc3 ENSMUST00000202261.5 microrchidia 3 (from RefSeq NM_001045529.3) A6H605 ENSMUST00000202261.1 ENSMUST00000202261.2 ENSMUST00000202261.3 ENSMUST00000202261.4 F7BJB9 MORC3_MOUSE Morc3 NM_001045529 Nxp2 Q4QQR6 Q6A0C2 Q8R0R0 Zcwcc3 uc008aaa.1 uc008aaa.2 uc008aaa.3 Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0. Dimerization of the ATPase domain is strictly required for the catalytic activity and binding to double-stranded DNA. Disrupting the interface between ATPase and the CW domains releases autoinhibition since the CW domain sterically impedes binding of the ATPase domain to DNA. Homodimer. The sumoylated form interacts with PML (via SUMO- interacting motif). Interacts with TP53. Nucleus, nucleoplasm Nucleus matrix Nucleus, PML body Chromosome Note=Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent. The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3. Sumoylation is involved in interaction with PML and localization to PML nuclear bodies. Lethality occurs at birth or within a day thereafter, for unknown reasons. Embryos at 14.5 dpc are morphologically indistinguishable from wild type (PubMed:17332504). MORC3 deletion leads to increased osteoblast differentiation and altered osteoblastic gene expression through up-regulation of IFN- beta/STAT1 signaling pathway (PubMed:27188231). Sequence=BAD32174.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function RNA binding nucleus nucleoplasm protein phosphorylation cell aging zinc ion binding post-embryonic development nuclear matrix PML body peptidyl-serine phosphorylation metal ion binding negative regulation of fibroblast proliferation protein stabilization maintenance of protein location in nucleus uc008aaa.1 uc008aaa.2 uc008aaa.3 
ENSMUST00000202274.2 Gm42726 ENSMUST00000202274.2 Gm42726 (from geneSymbol) ENSMUST00000202274.1 uc290vww.1 uc290vww.2 uc290vww.1 uc290vww.2 
ENSMUST00000202276.2 Gm42789 ENSMUST00000202276.2 Gm42789 (from geneSymbol) BC134377 ENSMUST00000202276.1 uc290ypo.1 uc290ypo.2 uc290ypo.1 uc290ypo.2 
ENSMUST00000202281.4 Rogdi ENSMUST00000202281.4 rogdi homolog (from RefSeq NM_133185.2) ENSMUST00000202281.1 ENSMUST00000202281.2 ENSMUST00000202281.3 Lzf NM_133185 Q3TDK6 Q8BL37 Q922N4 Q923H8 ROGDI_MOUSE uc007ybk.1 uc007ybk.2 uc007ybk.3 Monomer. Nucleus envelope Presynapse Cell projection, axon Perikaryon Cell projection, dendrite Cytoplasmic vesicle, secretory vesicle, synaptic vesicle Note=Detected primarily at presynaptic sites on axons, and to a lesser degree in soma and dendrites. Not detected at post-synaptic sites. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TDK6-1; Sequence=Displayed; Name=2; IsoId=Q3TDK6-2; Sequence=VSP_030600; Name=3; IsoId=Q3TDK6-3; Sequence=VSP_030601; Detected in brain, kidney and testis. Belongs to the rogdi family. Sequence=AAK71345.1; Type=Frameshift; Evidence=; molecular_function nucleus nuclear envelope plasma membrane vacuolar acidification brain development synaptic vesicle positive regulation of cell proliferation membrane neurogenesis cell junction hemopoiesis axon dendrite cytoplasmic vesicle developmental process odontogenesis of dentin-containing tooth presynaptic membrane cell projection perikaryon RAVE complex synapse presynapse uc007ybk.1 uc007ybk.2 uc007ybk.3 
ENSMUST00000202292.2 Gm42572 ENSMUST00000202292.2 Gm42572 (from geneSymbol) ENSMUST00000202292.1 uc290whn.1 uc290whn.2 uc290whn.1 uc290whn.2 
ENSMUST00000202297.2 2900076G11Rik ENSMUST00000202297.2 2900076G11Rik (from geneSymbol) ENSMUST00000202297.1 uc290uii.1 uc290uii.2 uc290uii.1 uc290uii.2 
ENSMUST00000202328.2 Gm43323 ENSMUST00000202328.2 Gm43323 (from geneSymbol) AK143473 ENSMUST00000202328.1 uc057aaa.1 uc057aaa.2 uc057aaa.3 uc057aaa.1 uc057aaa.2 uc057aaa.3 
ENSMUST00000202329.2 Gm43748 ENSMUST00000202329.2 Gm43748 (from geneSymbol) AK015278 ENSMUST00000202329.1 uc291dmg.1 uc291dmg.2 uc291dmg.1 uc291dmg.2 
ENSMUST00000202336.2 Gm42576 ENSMUST00000202336.2 Gm42576 (from geneSymbol) ENSMUST00000202336.1 uc290wlh.1 uc290wlh.2 uc290wlh.1 uc290wlh.2 
ENSMUST00000202337.2 Gm43443 ENSMUST00000202337.2 Gm43443 (from geneSymbol) ENSMUST00000202337.1 uc291dno.1 uc291dno.2 uc291dno.1 uc291dno.2 
ENSMUST00000202338.2 Gm43156 ENSMUST00000202338.2 Gm43156 (from geneSymbol) AK133111 ENSMUST00000202338.1 uc291bws.1 uc291bws.2 uc291bws.1 uc291bws.2 
ENSMUST00000202348.2 Gm43658 ENSMUST00000202348.2 Gm43658 (from geneSymbol) ENSMUST00000202348.1 uc290wnb.1 uc290wnb.2 uc290wnb.1 uc290wnb.2 
ENSMUST00000202351.2 Gm43461 ENSMUST00000202351.2 Gm43461 (from geneSymbol) ENSMUST00000202351.1 uc291bvp.1 uc291bvp.2 uc291bvp.1 uc291bvp.2 
ENSMUST00000202355.2 Vmn1r261 ENSMUST00000202355.2 Vmn1r261 (from geneSymbol) ENSMUST00000202355.1 NR_190750 uc291cfz.1 uc291cfz.2 uc291cfz.1 uc291cfz.2 
ENSMUST00000202365.2 Gm42906 ENSMUST00000202365.2 Gm42906 (from geneSymbol) A0A0J9YTR8 A0A0J9YTR8_MOUSE AK050259 ENSMUST00000202365.1 Gm42906 uc291cdu.1 uc291cdu.2 uc291cdu.1 uc291cdu.2 
ENSMUST00000202376.2 Gm43279 ENSMUST00000202376.2 Gm43279 (from geneSymbol) ENSMUST00000202376.1 LF194977 uc290wak.1 uc290wak.2 uc290wak.1 uc290wak.2 
ENSMUST00000202387.2 Gm43579 ENSMUST00000202387.2 Gm43579 (from geneSymbol) AK028021 ENSMUST00000202387.1 uc290zct.1 uc290zct.2 uc290zct.1 uc290zct.2 
ENSMUST00000202390.4 Gm43698 ENSMUST00000202390.4 Gm43698 (from geneSymbol) ENSMUST00000202390.1 ENSMUST00000202390.2 ENSMUST00000202390.3 uc290wbw.1 uc290wbw.2 uc290wbw.3 uc290wbw.4 uc290wbw.1 uc290wbw.2 uc290wbw.3 uc290wbw.4 
ENSMUST00000202392.2 Gm42549 ENSMUST00000202392.2 Gm42549 (from geneSymbol) ENSMUST00000202392.1 LF195357 uc291cyr.1 uc291cyr.2 uc291cyr.1 uc291cyr.2 
ENSMUST00000202396.2 Gm43843 ENSMUST00000202396.2 Gm43843 (from geneSymbol) AK018644 ENSMUST00000202396.1 uc291ctw.1 uc291ctw.2 uc291ctw.1 uc291ctw.2 
ENSMUST00000202399.2 Gm43040 ENSMUST00000202399.2 Gm43040 (from geneSymbol) AK079041 ENSMUST00000202399.1 uc290xaz.1 uc290xaz.2 uc290xaz.1 uc290xaz.2 
ENSMUST00000202406.4 Rph3a ENSMUST00000202406.4 rabphilin 3A, transcript variant 2 (from RefSeq NM_001302344.1) ENSMUST00000202406.1 ENSMUST00000202406.2 ENSMUST00000202406.3 NM_001302344 P47708 RP3A_MOUSE uc008zim.1 uc008zim.2 uc008zim.3 uc008zim.4 uc008zim.5 Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP- dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Interacts with RAB3B, RAB3C, RAB3D, RAB8A, RAB27A and RAB27B (PubMed:12578829). Interacts with RAB3A; this interaction recruits RPH3A to synaptic vesicules (By similarity). Interacts (via C2B domain) with SNAP25 (By similarity). Interacts with deubiquitinating enzyme CAND1; this interaction results in the deubiquitination of RPH3A (By similarity). Interacts with GRIN2A and DLG4; this ternary complex regulates NMDA receptor composition at postsynaptic membranes (By similarity). Interacts with SNCA (By similarity). P47708; Q9ERI2: Rab27a; NbExp=2; IntAct=EBI-398376, EBI-398172; P47708; P63011: Rab3a; NbExp=2; IntAct=EBI-398376, EBI-398393; P47708; P55258: Rab8a; NbExp=2; IntAct=EBI-398376, EBI-398411; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Cell projection, dendritic spine Postsynaptic cell membrane Membrane ; Peripheral membrane protein Specifically expressed in brain. Binds calcium via the C2 domains. The calcium-bound C2 domains mediate interactions with phospholipid bilayers. Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation. No visible phenotype. Mice are viable and fertile and do not display any physiological impairment. Additionally, synaptic properties seem unaffected. calcium ion binding protein binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding cytosol plasma membrane intracellular protein transport synaptic vesicle zinc ion binding lipid binding selenium binding protein transport membrane Rab GTPase binding extrinsic component of membrane cell junction secretory granule synaptic vesicle membrane cytoplasmic vesicle neuromuscular junction macromolecular complex phosphate ion binding cell projection neuron projection dendritic spine macromolecular complex binding synapse postsynaptic membrane metal ion binding spontaneous neurotransmitter secretion inositol 1,4,5 trisphosphate binding dendritic spine organization extrinsic component of synaptic vesicle membrane cholinergic synapse regulation of N-methyl-D-aspartate selective glutamate receptor activity Golgi apparatus uc008zim.1 uc008zim.2 uc008zim.3 uc008zim.4 uc008zim.5 
ENSMUST00000202425.2 Gm42888 ENSMUST00000202425.2 Gm42888 (from geneSymbol) ENSMUST00000202425.1 uc290wdq.1 uc290wdq.2 uc290wdq.1 uc290wdq.2 
ENSMUST00000202427.2 Gm42477 ENSMUST00000202427.2 Gm42477 (from geneSymbol) ENSMUST00000202427.1 uc289cfa.1 uc289cfa.2 uc289cfa.1 uc289cfa.2 
ENSMUST00000202437.2 Gm43059 ENSMUST00000202437.2 Gm43059 (from geneSymbol) AK085868 ENSMUST00000202437.1 uc290uhl.1 uc290uhl.2 uc290uhl.1 uc290uhl.2 
ENSMUST00000202439.2 Gm43093 ENSMUST00000202439.2 Gm43093 (from geneSymbol) ENSMUST00000202439.1 uc290vic.1 uc290vic.2 uc290vic.1 uc290vic.2 
ENSMUST00000202446.2 Gm42727 ENSMUST00000202446.2 Gm42727 (from geneSymbol) ENSMUST00000202446.1 LF194973 uc290vxc.1 uc290vxc.2 uc290vxc.1 uc290vxc.2 
ENSMUST00000202447.4 Fbxo21 ENSMUST00000202447.4 F-box protein 21, transcript variant 1 (from RefSeq NM_145564.4) ENSMUST00000202447.1 ENSMUST00000202447.2 ENSMUST00000202447.3 FBX21_MOUSE Fbx21 Kiaa0875 NM_145564 Q8BHA5 Q8CHC6 Q8VDH1 uc008zga.1 uc008zga.2 uc008zga.3 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Directly interacts with SKP1 and CUL1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VDH1-1; Sequence=Displayed; Name=2; IsoId=Q8VDH1-2; Sequence=VSP_011350; Sequence=BAC41454.1; Type=Erroneous initiation; Evidence=; DNA binding cellular_component biological_process uc008zga.1 uc008zga.2 uc008zga.3 
ENSMUST00000202454.2 Gm43343 ENSMUST00000202454.2 Gm43343 (from geneSymbol) ENSMUST00000202454.1 uc290wac.1 uc290wac.2 uc290wac.1 uc290wac.2 
ENSMUST00000202455.2 Gm43633 ENSMUST00000202455.2 Gm43633 (from geneSymbol) AK138754 ENSMUST00000202455.1 uc291jdz.1 uc291jdz.2 uc291jdz.1 uc291jdz.2 
ENSMUST00000202462.2 Gm43845 ENSMUST00000202462.2 Gm43845 (from geneSymbol) AK050631 ENSMUST00000202462.1 uc291cti.1 uc291cti.2 uc291cti.1 uc291cti.2 
ENSMUST00000202469.2 Gm42887 ENSMUST00000202469.2 Gm42887 (from geneSymbol) AK139779 ENSMUST00000202469.1 uc290wdu.1 uc290wdu.2 uc290wdu.1 uc290wdu.2 
ENSMUST00000202475.2 Gm42802 ENSMUST00000202475.2 Gm42802 (from geneSymbol) ENSMUST00000202475.1 uc290wll.1 uc290wll.2 uc290wll.1 uc290wll.2 
ENSMUST00000202482.2 Gm43598 ENSMUST00000202482.2 Gm43598 (from geneSymbol) AK035593 ENSMUST00000202482.1 uc291cct.1 uc291cct.2 uc291cct.1 uc291cct.2 
ENSMUST00000202489.2 C130093G08Rik ENSMUST00000202489.2 RIKEN cDNA C130093G08 gene (from RefSeq NR_187947.1) ENSMUST00000202489.1 NR_187947 uc291cws.1 uc291cws.2 uc291cws.1 uc291cws.2 
ENSMUST00000202491.2 Gm43460 ENSMUST00000202491.2 Gm43460 (from geneSymbol) ENSMUST00000202491.1 uc291bvq.1 uc291bvq.2 uc291bvq.1 uc291bvq.2 
ENSMUST00000202492.2 Gm43792 ENSMUST00000202492.2 Gm43792 (from geneSymbol) ENSMUST00000202492.1 uc290vzu.1 uc290vzu.2 uc290vzu.1 uc290vzu.2 
ENSMUST00000202495.2 Gm43152 ENSMUST00000202495.2 Gm43152 (from geneSymbol) ENSMUST00000202495.1 uc291bzy.1 uc291bzy.2 uc291bzy.1 uc291bzy.2 
ENSMUST00000202497.2 1700030N18Rik ENSMUST00000202497.2 1700030N18Rik (from geneSymbol) ENSMUST00000202497.1 uc291aip.1 uc291aip.2 uc291aip.1 uc291aip.2 
ENSMUST00000202498.2 Gm43374 ENSMUST00000202498.2 Gm43374 (from geneSymbol) ENSMUST00000202498.1 uc290wdm.1 uc290wdm.2 uc290wdm.1 uc290wdm.2 
ENSMUST00000202511.2 Gm43332 ENSMUST00000202511.2 Gm43332 (from geneSymbol) ENSMUST00000202511.1 uc291bze.1 uc291bze.2 uc291bze.1 uc291bze.2 
ENSMUST00000202512.2 Gm42858 ENSMUST00000202512.2 Gm42858 (from geneSymbol) AK081141 ENSMUST00000202512.1 uc290uzo.1 uc290uzo.2 uc290uzo.1 uc290uzo.2 
ENSMUST00000202522.2 Gm43281 ENSMUST00000202522.2 Gm43281 (from geneSymbol) AK149195 ENSMUST00000202522.1 uc290wat.1 uc290wat.2 uc290wat.1 uc290wat.2 
ENSMUST00000202523.3 Gm42884 ENSMUST00000202523.3 Gm42884 (from geneSymbol) ENSMUST00000202523.1 ENSMUST00000202523.2 uc291ala.1 uc291ala.2 uc291ala.3 uc291ala.1 uc291ala.2 uc291ala.3 
ENSMUST00000202526.2 ENSMUSG00000121805 ENSMUST00000202526.2 ENSMUSG00000121805 (from geneSymbol) ENSMUST00000202526.1 uc291cfy.1 uc291cfy.2 uc291cfy.1 uc291cfy.2 
ENSMUST00000202529.2 Gm43164 ENSMUST00000202529.2 Gm43164 (from geneSymbol) ENSMUST00000202529.1 uc291djz.1 uc291djz.2 uc291djz.1 uc291djz.2 
ENSMUST00000202533.2 Gm43635 ENSMUST00000202533.2 Gm43635 (from geneSymbol) ENSMUST00000202533.1 uc291jdm.1 uc291jdm.2 uc291jdm.1 uc291jdm.2 
ENSMUST00000202534.2 Gm43808 ENSMUST00000202534.2 Gm43808 (from geneSymbol) ENSMUST00000202534.1 uc290uba.1 uc290uba.2 uc290uba.1 uc290uba.2 
ENSMUST00000202535.4 Zfp936 ENSMUST00000202535.4 zinc finger protein 936 (from RefSeq NM_001034893.2) EG435970 ENSMUST00000202535.1 ENSMUST00000202535.2 ENSMUST00000202535.3 Gm9272 NM_001034893 Q3ULA8 Q3ULA8_MOUSE Zfp936 uc009gmh.1 uc009gmh.2 May be involved in transcriptional regulation. RNA polymerase II regulatory region sequence-specific DNA binding nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated chromatin DNA binding sequence-specific DNA binding positive regulation of transcription, DNA-templated metal ion binding uc009gmh.1 uc009gmh.2 
ENSMUST00000202536.2 Gm43086 ENSMUST00000202536.2 Gm43086 (from geneSymbol) AK143337 ENSMUST00000202536.1 uc290wzk.1 uc290wzk.2 uc290wzk.1 uc290wzk.2 
ENSMUST00000202545.2 Gm43274 ENSMUST00000202545.2 Gm43274 (from geneSymbol) ENSMUST00000202545.1 uc290zah.1 uc290zah.2 uc290zah.1 uc290zah.2 
ENSMUST00000202548.2 4930430O22Rik ENSMUST00000202548.2 4930430O22Rik (from geneSymbol) AK019590 ENSMUST00000202548.1 uc290yub.1 uc290yub.2 uc290yub.1 uc290yub.2 
ENSMUST00000202552.2 Gm43373 ENSMUST00000202552.2 Gm43373 (from geneSymbol) ENSMUST00000202552.1 uc290wdl.1 uc290wdl.2 uc290wdl.1 uc290wdl.2 
ENSMUST00000202553.2 Gm43764 ENSMUST00000202553.2 Gm43764 (from geneSymbol) AK143415 ENSMUST00000202553.1 uc289vnt.1 uc289vnt.2 uc289vnt.1 uc289vnt.2 
ENSMUST00000202562.2 Gm42801 ENSMUST00000202562.2 Gm42801 (from geneSymbol) AK138139 ENSMUST00000202562.1 uc291cyj.1 uc291cyj.2 uc291cyj.1 uc291cyj.2 
ENSMUST00000202569.4 Spam1 ENSMUST00000202569.4 sperm adhesion molecule 1, transcript variant 2 (from RefSeq NM_009241.3) ENSMUST00000202569.1 ENSMUST00000202569.2 ENSMUST00000202569.3 HYALP_MOUSE NM_009241 P48794 Ph20 Q7TSD6 Q812F4 Q9DAQ1 Spam uc009bca.1 uc009bca.2 uc009bca.3 Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D- glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35; Cell membrane; Lipid-anchor, GPI-anchor. Belongs to the glycosyl hydrolase 56 family. acrosomal vesicle catalytic activity hyalurononglucosaminidase activity plasma membrane carbohydrate metabolic process cell adhesion single fertilization fusion of sperm to egg plasma membrane metabolic process external side of plasma membrane membrane hydrolase activity hydrolase activity, acting on glycosyl bonds anchored component of membrane membrane raft uc009bca.1 uc009bca.2 uc009bca.3 
ENSMUST00000202576.4 Nrbp1 ENSMUST00000202576.4 nuclear receptor binding protein 1, transcript variant 1 (from RefSeq NM_001347326.1) D3YUV1 D3YUV1_MOUSE ENSMUST00000202576.1 ENSMUST00000202576.2 ENSMUST00000202576.3 NM_001347326 Nrbp1 uc008wxu.1 uc008wxu.2 uc008wxu.3 uc008wxu.4 protein kinase activity ATP binding protein phosphorylation uc008wxu.1 uc008wxu.2 uc008wxu.3 uc008wxu.4 
ENSMUST00000202583.4 Gm20005 ENSMUST00000202583.4 Gm20005 (from geneSymbol) AK146146 ENSMUST00000202583.1 ENSMUST00000202583.2 ENSMUST00000202583.3 uc009aqb.1 uc009aqb.2 uc009aqb.3 uc009aqb.4 uc009aqb.1 uc009aqb.2 uc009aqb.3 uc009aqb.4 
ENSMUST00000202592.2 1810017P11Rik ENSMUST00000202592.2 1810017P11Rik (from geneSymbol) AK007529 ENSMUST00000202592.1 uc290yrp.1 uc290yrp.2 uc290yrp.1 uc290yrp.2 
ENSMUST00000202607.3 A430102K17Rik ENSMUST00000202607.3 A430102K17Rik (from geneSymbol) AK020756 ENSMUST00000202607.1 ENSMUST00000202607.2 uc290ytn.1 uc290ytn.2 uc290ytn.3 uc290ytn.1 uc290ytn.2 uc290ytn.3 
ENSMUST00000202626.3 BC049739 ENSMUST00000202626.3 BC049739 (from geneSymbol) ENSMUST00000202626.1 ENSMUST00000202626.2 uc291djg.1 uc291djg.2 uc291djg.3 uc291djg.1 uc291djg.2 uc291djg.3 
ENSMUST00000202642.5 Pramel42 ENSMUST00000202642.5 PRAME like 42, transcript variant 2 (from RefSeq NM_001243938.1) ENSMUST00000202642.1 ENSMUST00000202642.2 ENSMUST00000202642.3 ENSMUST00000202642.4 J3QK78 J3QK78_MOUSE NM_001243938 Pramel42 uc029vjp.1 uc029vjp.2 uc029vjp.3 uc029vjp.4 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc029vjp.1 uc029vjp.2 uc029vjp.3 uc029vjp.4 
ENSMUST00000202644.2 Gm42728 ENSMUST00000202644.2 Gm42728 (from geneSymbol) ENSMUST00000202644.1 uc290vxn.1 uc290vxn.2 uc290vxn.1 uc290vxn.2 
ENSMUST00000202645.4 Zfp825 ENSMUST00000202645.4 zinc finger protein 825, transcript variant 2 (from RefSeq NM_146231.2) BC012278 ENSMUST00000202645.1 ENSMUST00000202645.2 ENSMUST00000202645.3 NM_146231 Q91VL6 Q91VL6_MOUSE Zfp825 uc007rfg.1 uc007rfg.2 uc007rfg.3 Belongs to the krueppel C2H2-type zinc-finger protein family. molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc007rfg.1 uc007rfg.2 uc007rfg.3 
ENSMUST00000202649.2 Gm42852 ENSMUST00000202649.2 Gm42852 (from geneSymbol) AK089374 ENSMUST00000202649.1 uc291csr.1 uc291csr.2 uc291csr.1 uc291csr.2 
ENSMUST00000202651.4 Clock ENSMUST00000202651.4 clock circadian regulator, transcript variant 2 (from RefSeq NM_001289826.1) CLOCK_MOUSE ENSMUST00000202651.1 ENSMUST00000202651.2 ENSMUST00000202651.3 NM_001289826 O08785 uc008xus.1 uc008xus.2 uc008xus.3 The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with Arntl (Bmal1) that binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Polymorphisms in this gene may be associated with behavioral changes, obesity, and metabolic syndrome. Two transcripts encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]. Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post- translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. May play a role in spermatogenesis; contributes to the chromatoid body assembly and physiology. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6- nucleotide E-box sequence (By similarity). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (By similarity). The CLOCK-BMAL1 heterodimer also recognizes the non- canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3'. CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR- induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region. The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner (By similarity). Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (PubMed:30012868). Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=; Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (PubMed:11779462). Forms a heterodimer with BMAL1 (PubMed:9616112, PubMed:12897057, PubMed:16717091, PubMed:16980631, PubMed:18662546, PubMed:19946213, PubMed:22653727). The CLOCK-BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and for phosphorylation of both CLOCK and BMAL1 (PubMed:12897057). Interacts with NR3C1 in a ligand-dependent fashion (PubMed:19141540). Interacts with ESR1 and estrogen stimulates this interaction (By similarity). Interacts with the complex p35/CDK5 (PubMed:24235147). Interacts with RELA/p65 (PubMed:22895791). Interacts with KAT2B, CREBBP and EP300 (By similarity). Interacts with ID1 and ID3 (PubMed:20861012). Interacts with ID2 (PubMed:20861012). Interacts with MTA1 (PubMed:24089055). Interacts with OGA (PubMed:23395175). Interacts with SIRT1 (PubMed:18662546, PubMed:18662547). Interacts with CIPC (PubMed:17310242). Interacts with EZH2 (PubMed:16717091). Interacts with EIF4E, PIWIL1 and DDX4 (PubMed:22900038). Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus (PubMed:16717091, PubMed:18430226, PubMed:18662546). Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation. Interaction of the CLOCK-BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA (By similarity). The CLOCK- BMAL1 heterodimer interacts with GSK3B (PubMed:19946213). Interacts with KDM5A (PubMed:21960634). Interacts with KMT2A; in a circadian manner (PubMed:21113167). Interacts with MYBBP1A (PubMed:19129230). Interacts with THRAP3 (PubMed:24043798). Interacts with MED1; this interaction requires the presence of THRAP3 (PubMed:24043798). Interacts with NCOA2 (PubMed:24529706). The CLOCK-BMAL1 heterodimer interacts with PASD1. Interacts with NDUFA9. Interacts with IMPDH2; in a circadian manner (By similarity). Interacts with ASS1; in a circadian manner (PubMed:28985504). Interacts with PIWIL2 (via PIWI domain) (PubMed:28903391). Interacts with HNF4A (By similarity). O08785; Q9WTL8: Bmal1; NbExp=39; IntAct=EBI-79859, EBI-644534; O08785; Q9WTL8-2: Bmal1; NbExp=2; IntAct=EBI-79859, EBI-644559; O08785; Q9WTL8-4: Bmal1; NbExp=10; IntAct=EBI-79859, EBI-644568; O08785; P97784: Cry1; NbExp=10; IntAct=EBI-79859, EBI-1266607; O08785; Q9JMK2: Csnk1e; NbExp=2; IntAct=EBI-79859, EBI-771709; O08785; Q3U1J4: Ddb1; NbExp=4; IntAct=EBI-79859, EBI-2552275; O08785; O54943: Per2; NbExp=10; IntAct=EBI-79859, EBI-1266779; O08785; P20444: Prkca; NbExp=3; IntAct=EBI-79859, EBI-6976815; O08785; Q923E4: Sirt1; NbExp=11; IntAct=EBI-79859, EBI-1802585; O08785; P67870: CSNK2B; Xeno; NbExp=2; IntAct=EBI-79859, EBI-348169; O08785; Q03164: KMT2A; Xeno; NbExp=3; IntAct=EBI-79859, EBI-591370; O08785; Q14995: NR1D2; Xeno; NbExp=2; IntAct=EBI-79859, EBI-6144053; O08785; P62136: PPP1CA; Xeno; NbExp=2; IntAct=EBI-79859, EBI-357253; O08785; P62140: PPP1CB; Xeno; NbExp=2; IntAct=EBI-79859, EBI-352350; O08785; P36873: PPP1CC; Xeno; NbExp=2; IntAct=EBI-79859, EBI-356283; O08785; P30154: PPP2R1B; Xeno; NbExp=2; IntAct=EBI-79859, EBI-357094; O08785; Q14738: PPP2R5D; Xeno; NbExp=2; IntAct=EBI-79859, EBI-396563; O08785; Q92753: RORB; Xeno; NbExp=2; IntAct=EBI-79859, EBI-6144615; O08785; P51449: RORC; Xeno; NbExp=2; IntAct=EBI-79859, EBI-3908771; Nucleus toplasm toplasm, cytosol Note=Localizes to sites of DNA damage in a H2AX-independent manner (By similarity). Shuttling between the cytoplasm and the nucleus is under circadian regulation and is BMAL1- dependent. Phosphorylated form located in the nucleus predominantly between CT12 and CT21. Nonphosphorylated form found only in the cytoplasm. Sequestered to the cytoplasm in the presence of ID2. Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=O08785-1; Sequence=Displayed; Name=Short; IsoId=O08785-2; Sequence=VSP_002103; Expressed equally in brain, eye, testes, ovaries, liver, heart, lung, kidney. In the brain, expression is abundant in the suprachiasmatic nuclei (SCN), in the pyriform cortex, and in the hippocampus. Low expression throughout the rest of the brain. Expression does not appear to undergo circadian oscillations. In the SCN, nuclear expression is lowest between CT7 and CT13. Cytoplasmic expression is highest at these times. In liver, peak levels from CT21 to CT3. Expression of both phosphorylated and unphosphorylated forms of BMAL1 with other circadian clock proteins occurs between CT15 and CT18. Expression in the heart oscillates in a circadian manner. Contains a Gln-rich C-terminal domain which could correspond to the transactivation domain. Ubiquitinated, leading to its proteasomal degradation. O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-BMAL1 heterodimer thereby increasing CLOCK-BMAL1-mediated transcriptional activation of PER1/2/3 and CRY1/2. Phosphorylation is dependent on the CLOCK-BMAL1 heterodimer formation. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver: the hyperphosphorylated form peaks at midnight (CT18), while the hypophosphorylated form is abundant throughout the day. May be phosphorylated by CSNK1D and CKSN1E. Sumoylation enhances its transcriptional activity and interaction with ESR1, resulting in up-regulation of ESR1 activity. Estrogen stimulates sumoylation. Desumoylation by SENP1 negatively regulates its transcriptional activity. Undergoes lysosome-mediated degradation in a time-dependent manner in the liver. The naturally-occurring CLOCK variant, missing exon 19 (deletion of AA 514-564) due to an A-->T nucleotide transversion in a splice donor site, forms a heterodimer with DNA, but fails to activate transcription. Homozygous CLOCK mutants have a circadian rhythm that is increased from 3 to 4 hours and usually the circadian rhythmicity is lost at constant darkness. Expression of CLOCK is also reduced. There also exists an alternative spliced CLOCK variant missing both exon 18 and exon 19 (AA 484-564). DNA damage checkpoint RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding histone acetyltransferase activity protein binding nucleus nucleoplasm transcription factor complex chromosome perichromatin fibrils nucleolus cytoplasm rough endoplasmic reticulum cytosol regulation of transcription, DNA-templated protein acetylation cellular response to DNA damage stimulus spermatogenesis circadian rhythm transcription factor binding histone acetylation transferase activity transferase activity, transferring acyl groups chromatin DNA binding circadian regulation of gene expression chromatoid body regulation of hair cycle regulation of circadian rhythm proteasome-mediated ubiquitin-dependent protein catabolic process intracellular membrane-bounded organelle sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein dimerization activity rhythmic process positive regulation of inflammatory response regulation of insulin secretion positive regulation of NF-kappaB transcription factor activity response to redox state E-box binding cellular response to ionizing radiation regulation of type B pancreatic cell development negative regulation of glucocorticoid receptor signaling pathway uc008xus.1 uc008xus.2 uc008xus.3 
ENSMUST00000202662.2 Gm43372 ENSMUST00000202662.2 Gm43372 (from geneSymbol) AK041432 ENSMUST00000202662.1 uc291amj.1 uc291amj.2 uc291amj.1 uc291amj.2 
ENSMUST00000202669.2 Gm42548 ENSMUST00000202669.2 Gm42548 (from geneSymbol) ENSMUST00000202669.1 LF195358 uc291cys.1 uc291cys.2 uc291cys.1 uc291cys.2 
ENSMUST00000202671.2 Gm43634 ENSMUST00000202671.2 Gm43634 (from geneSymbol) ENSMUST00000202671.1 uc291jec.1 uc291jec.2 uc291jec.1 uc291jec.2 
ENSMUST00000202673.3 N4bp2os ENSMUST00000202673.3 N4bp2os (from geneSymbol) ENSMUST00000202673.1 ENSMUST00000202673.2 KY468045 uc057lmf.1 uc057lmf.2 uc057lmf.3 uc057lmf.1 uc057lmf.2 uc057lmf.3 
ENSMUST00000202678.2 Gm42583 ENSMUST00000202678.2 Gm42583 (from geneSymbol) AK043453 ENSMUST00000202678.1 uc291cuy.1 uc291cuy.2 uc291cuy.1 uc291cuy.2 
ENSMUST00000202680.2 Gm43599 ENSMUST00000202680.2 Gm43599 (from geneSymbol) ENSMUST00000202680.1 uc290xbi.1 uc290xbi.2 uc290xbi.1 uc290xbi.2 
ENSMUST00000202683.3 Gm42530 ENSMUST00000202683.3 Gm42530 (from geneSymbol) AK136607 ENSMUST00000202683.1 ENSMUST00000202683.2 uc290wzp.1 uc290wzp.2 uc290wzp.3 uc290wzp.1 uc290wzp.2 uc290wzp.3 
ENSMUST00000202688.2 Gm36840 ENSMUST00000202688.2 Gm36840 (from geneSymbol) ENSMUST00000202688.1 uc290ujt.1 uc290ujt.2 uc290ujt.1 uc290ujt.2 
ENSMUST00000202692.5 Zfp958 ENSMUST00000202692.5 zinc finger protein 958, transcript variant 2 (from RefSeq NM_145591.5) BC003267 ENSMUST00000202692.1 ENSMUST00000202692.2 ENSMUST00000202692.3 ENSMUST00000202692.4 NM_145591 Q99LG7 Q99LG7_MOUSE Zfp958 uc009ktz.1 uc009ktz.2 uc009ktz.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc009ktz.1 uc009ktz.2 uc009ktz.3 
ENSMUST00000202694.2 Gm43790 ENSMUST00000202694.2 Gm43790 (from geneSymbol) AK051566 ENSMUST00000202694.1 uc290vzo.1 uc290vzo.2 uc290vzo.1 uc290vzo.2 
ENSMUST00000202699.2 Gm40309 ENSMUST00000202699.2 Gm40309 (from geneSymbol) ENSMUST00000202699.1 uc290vwv.1 uc290vwv.2 uc290vwv.1 uc290vwv.2 
ENSMUST00000202706.2 Or10a3n ENSMUST00000202706.2 olfactory receptor family 10 subfamily A member 3N (from RefSeq NM_207160.1) ENSMUST00000202706.1 NM_207160 Olfr519 Or10a3n Q7TRU3 Q7TRU3_MOUSE uc009jda.1 uc009jda.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jda.1 uc009jda.2 
ENSMUST00000202708.2 Gm10459 ENSMUST00000202708.2 predicted gene 10459 (from RefSeq NR_188775.1) ENSMUST00000202708.1 NR_188775 uc056zzh.1 uc056zzh.2 uc056zzh.3 uc056zzh.4 uc056zzh.5 uc056zzh.1 uc056zzh.2 uc056zzh.3 uc056zzh.4 uc056zzh.5 
ENSMUST00000202709.2 Gm42713 ENSMUST00000202709.2 Gm42713 (from geneSymbol) AK156160 ENSMUST00000202709.1 uc290wbf.1 uc290wbf.2 uc290wbf.1 uc290wbf.2 
ENSMUST00000202719.2 Gm6598 ENSMUST00000202719.2 Gm6598 (from geneSymbol) ENSMUST00000202719.1 uc291afu.1 uc291afu.2 uc291afu.1 uc291afu.2 
ENSMUST00000202722.2 Ncbp2as2 ENSMUST00000202722.2 Ncbp2 antisense 2 (head to head) (from RefSeq NM_134107.1) 0610012G03Rik A0A0J9YTR2 A0A0J9YTR2_MOUSE ENSMUST00000202722.1 NM_134107 Ncbp2as2 uc007yxy.1 uc007yxy.2 uc007yxy.3 uc007yxy.4 uc007yxy.1 uc007yxy.2 uc007yxy.3 uc007yxy.4 
ENSMUST00000202733.2 Gm43621 ENSMUST00000202733.2 Gm43621 (from geneSymbol) ENSMUST00000202733.1 uc289voq.1 uc289voq.2 uc289voq.1 uc289voq.2 
ENSMUST00000202748.4 ENSMUSG00000121281 ENSMUST00000202748.4 ENSMUSG00000121281 (from geneSymbol) ENSMUST00000202748.1 ENSMUST00000202748.2 ENSMUST00000202748.3 uc290ukn.1 uc290ukn.2 uc290ukn.1 uc290ukn.2 
ENSMUST00000202755.2 Gm42545 ENSMUST00000202755.2 Gm42545 (from geneSymbol) AK081247 ENSMUST00000202755.1 uc290yzi.1 uc290yzi.2 uc290yzi.1 uc290yzi.2 
ENSMUST00000202768.2 Gm10399 ENSMUST00000202768.2 predicted gene 10399 (from RefSeq NR_188785.1) ENSMUST00000202768.1 NR_188785 uc290yyb.1 uc290yyb.2 uc290yyb.1 uc290yyb.2 
ENSMUST00000202782.2 Gm42655 ENSMUST00000202782.2 Gm42655 (from geneSymbol) AK082811 ENSMUST00000202782.1 uc290zbs.1 uc290zbs.2 uc290zbs.1 uc290zbs.2 
ENSMUST00000202790.3 Gm43782 ENSMUST00000202790.3 Gm43782 (from geneSymbol) ENSMUST00000202790.1 ENSMUST00000202790.2 uc290zam.1 uc290zam.2 uc290zam.3 uc290zam.1 uc290zam.2 uc290zam.3 
ENSMUST00000202797.2 Gm43482 ENSMUST00000202797.2 Gm43482 (from geneSymbol) AK048351 ENSMUST00000202797.1 uc291aeo.1 uc291aeo.2 uc291aeo.1 uc291aeo.2 
ENSMUST00000202798.2 Gm42742 ENSMUST00000202798.2 PAXIP1 associated glutamate rich protein 1A (from RefSeq NM_030240.1) ENSMUST00000202798.1 NM_030240 PGR1A_MOUSE Pa1 Pagr Pagr1a Q99L02 uc009jtx.1 uc009jtx.2 Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (PubMed:26744420). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (PubMed:26744420). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (By similarity). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (By similarity). May be involved in the regulation of the BMP pathway in extraembryonic development (PubMed:24633704). Component of the KMT2 family MLL2/MLL3 complex, at least composed of the histone methyltransferases KMT2D and/or KMT2C, the common subunits ASH2L, RBBP5, WDR5 and DPY30, and the complex type- specific subunits PAXIP1/PTIP, PAGR1, NCOA6 and KDM6A; PAXIP1 is required for the association with the MLL2/MLL3 complex (By similarity). Forms a constitutive complex with PAXIP1/PTIP independently of the MLL2/MLL3 complex (PubMed:19124460, PubMed:26744420). Interacts with NCOA1, ESR1, NR3C1, AR (By similarity). Q99L02; Q6NZQ4: Paxip1; NbExp=11; IntAct=EBI-11667455, EBI-1395317; Nucleus Expression first detected at 5.0-6.0 dpc in the extraembryonic region, at 7.5 dpc detected within the chorion; later the expression is expanding to the entire embryo. Normal germ layer specification and developmental patterning but limited anterior development and arrest by 8.5 dpc, likely due at least in part to defects in extraembryonic tissue. The terminology of MLL proteins in mammalia is not consistent also concerning the terminology of MLL protein-containing complexes. The decribed MLL2/MLL3 complex is commonly described as MLL3/MLL4 complex in literature. protein binding nucleus nucleoplasm DNA repair DNA recombination cellular response to DNA damage stimulus estrogen receptor binding positive regulation of intracellular estrogen receptor signaling pathway histone methyltransferase complex MLL3/4 complex positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgG isotypes histone H3-K4 methylation chorion development histone H3-K27 demethylation regulation of cell cycle G2/M phase transition positive regulation of cell cycle G1/S phase transition positive regulation of response to DNA damage stimulus uc009jtx.1 uc009jtx.2 
ENSMUST00000202802.2 ENSMUSG00000121826 ENSMUST00000202802.2 ENSMUSG00000121826 (from geneSymbol) AK017188 ENSMUST00000202802.1 uc290umi.1 uc290umi.2 uc290umi.1 uc290umi.2 
ENSMUST00000202826.2 Peg13 ENSMUST00000202826.2 paternally expressed 13 (from RefSeq NR_002864.2) ENSMUST00000202826.1 NR_002864 uc007wbo.1 uc007wbo.2 uc007wbo.3 uc007wbo.4 uc007wbo.1 uc007wbo.2 uc007wbo.3 uc007wbo.4 
ENSMUST00000202834.2 Gm42849 ENSMUST00000202834.2 Gm42849 (from geneSymbol) ENSMUST00000202834.1 uc290upj.1 uc290upj.2 uc290upj.1 uc290upj.2 
ENSMUST00000202838.2 Gm43371 ENSMUST00000202838.2 Gm43371 (from geneSymbol) AK039273 ENSMUST00000202838.1 uc290wdk.1 uc290wdk.2 uc290wdk.1 uc290wdk.2 
ENSMUST00000202850.2 Gm43294 ENSMUST00000202850.2 Gm43294 (from geneSymbol) AK041019 ENSMUST00000202850.1 uc291cgx.1 uc291cgx.2 uc291cgx.1 uc291cgx.2 
ENSMUST00000202859.2 Gm43085 ENSMUST00000202859.2 Gm43085 (from geneSymbol) AK085668 ENSMUST00000202859.1 uc290wzj.1 uc290wzj.2 uc290wzj.1 uc290wzj.2 
ENSMUST00000202862.2 Gm43811 ENSMUST00000202862.2 Gm43811 (from geneSymbol) ENSMUST00000202862.1 uc290uje.1 uc290uje.2 uc290uje.1 uc290uje.2 
ENSMUST00000202868.4 Ctbp1 ENSMUST00000202868.4 C-terminal binding protein 1, transcript variant 4 (from RefSeq NM_001198861.1) A0A0J9YU62 A0A0J9YU62_MOUSE Ctbp1 ENSMUST00000202868.1 ENSMUST00000202868.2 ENSMUST00000202868.3 NM_001198861 uc008xam.1 uc008xam.2 uc008xam.3 uc008xam.4 Nucleus Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor NAD binding oxidation-reduction process uc008xam.1 uc008xam.2 uc008xam.3 uc008xam.4 
ENSMUST00000202871.2 Gm43166 ENSMUST00000202871.2 Gm43166 (from geneSymbol) ENSMUST00000202871.1 uc291ago.1 uc291ago.2 uc291ago.1 uc291ago.2 
ENSMUST00000202881.2 Gm42524 ENSMUST00000202881.2 Gm42524 (from geneSymbol) AK047282 ENSMUST00000202881.1 uc057lma.1 uc057lma.2 uc057lma.1 uc057lma.2 
ENSMUST00000202883.2 Gm43039 ENSMUST00000202883.2 Gm43039 (from geneSymbol) AB346088 ENSMUST00000202883.1 uc290xae.1 uc290xae.2 uc290xae.1 uc290xae.2 
ENSMUST00000202887.2 Gm42732 ENSMUST00000202887.2 Gm42732 (from geneSymbol) ENSMUST00000202887.1 uc290wik.1 uc290wik.2 uc290wik.1 uc290wik.2 
ENSMUST00000202890.2 Gm43842 ENSMUST00000202890.2 Gm43842 (from geneSymbol) ENSMUST00000202890.1 uc290wdi.1 uc290wdi.2 uc290wdi.1 uc290wdi.2 
ENSMUST00000202891.2 ENSMUSG00000121741 ENSMUST00000202891.2 ENSMUSG00000121741 (from geneSymbol) BC127053 ENSMUST00000202891.1 uc291doe.1 uc291doe.2 uc291doe.1 uc291doe.2 
ENSMUST00000202893.2 5930420M18Rik ENSMUST00000202893.2 5930420M18Rik (from geneSymbol) ENSMUST00000202893.1 uc290ubs.1 uc290ubs.2 uc290ubs.1 uc290ubs.2 
ENSMUST00000202895.2 2700029L08Rik ENSMUST00000202895.2 2700029L08Rik (from geneSymbol) ENSMUST00000202895.1 uc291akz.1 uc291akz.2 uc291akz.1 uc291akz.2 
ENSMUST00000202902.2 Wdr95 ENSMUST00000202902.2 Wdr95 (from geneSymbol) AK087389 D3Z7A8 D3Z7A8_MOUSE ENSMUST00000202902.1 Wdr95 uc291cak.1 uc291cak.2 molecular_function cellular_component biological_process uc291cak.1 uc291cak.2 
ENSMUST00000202906.2 Gm43027 ENSMUST00000202906.2 Gm43027 (from geneSymbol) ENSMUST00000202906.1 uc290wdc.1 uc290wdc.2 uc290wdc.1 uc290wdc.2 
ENSMUST00000202914.2 Gm43791 ENSMUST00000202914.2 Gm43791 (from geneSymbol) ENSMUST00000202914.1 uc290utq.1 uc290utq.2 uc290utq.1 uc290utq.2 
ENSMUST00000202916.3 Pramel41 ENSMUST00000202916.3 Belongs to the PRAME family. (from UniProt A0A0J9YUM1) A0A0J9YUM1 A0A0J9YUM1_MOUSE ENSMUST00000202916.1 ENSMUST00000202916.2 Pramel41 uc290xfh.1 uc290xfh.2 uc290xfh.3 Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc290xfh.1 uc290xfh.2 uc290xfh.3 
ENSMUST00000202922.2 Gm43784 ENSMUST00000202922.2 Gm43784 (from geneSymbol) ENSMUST00000202922.1 uc290zao.1 uc290zao.2 uc290zao.1 uc290zao.2 
ENSMUST00000202923.2 G630022F23Rik ENSMUST00000202923.2 G630022F23Rik (from geneSymbol) ENSMUST00000202923.1 uc290uoc.1 uc290uoc.2 uc290uoc.1 uc290uoc.2 
ENSMUST00000202926.2 Gm43844 ENSMUST00000202926.2 Gm43844 (from geneSymbol) ENSMUST00000202926.1 uc291ctd.1 uc291ctd.2 uc291ctd.1 uc291ctd.2 
ENSMUST00000202931.2 Gm43771 ENSMUST00000202931.2 Gm43771 (from geneSymbol) AK017927 ENSMUST00000202931.1 uc290vyk.1 uc290vyk.2 uc290vyk.1 uc290vyk.2 
ENSMUST00000202933.2 Gm43533 ENSMUST00000202933.2 Gm43533 (from geneSymbol) AK054388 ENSMUST00000202933.1 uc291csq.1 uc291csq.2 uc291csq.1 uc291csq.2 
ENSMUST00000202942.2 Gm42575 ENSMUST00000202942.2 Gm42575 (from geneSymbol) AK087845 ENSMUST00000202942.1 uc290wld.1 uc290wld.2 uc290wld.1 uc290wld.2 
ENSMUST00000202943.2 Gm42963 ENSMUST00000202943.2 Gm42963 (from geneSymbol) AK089639 ENSMUST00000202943.1 uc291dqo.1 uc291dqo.2 uc291dqo.1 uc291dqo.2 
ENSMUST00000202950.4 Slc4a1ap ENSMUST00000202950.4 solute carrier family 4 (anion exchanger), member 1, adaptor protein, transcript variant 3 (from RefSeq NM_001359154.1) E9PX68 E9PX68_MOUSE ENSMUST00000202950.1 ENSMUST00000202950.2 ENSMUST00000202950.3 NM_001359154 Slc4a1ap uc057llx.1 uc057llx.2 uc057llx.3 mRNA binding protein binding nucleoplasm plasma membrane biological_process intracellular membrane-bounded organelle uc057llx.1 uc057llx.2 uc057llx.3 
ENSMUST00000202954.2 Gm42467 ENSMUST00000202954.2 Gm42467 (from geneSymbol) ENSMUST00000202954.1 LF195199 uc291afv.1 uc291afv.2 uc291afv.1 uc291afv.2 
ENSMUST00000202958.2 Gm43280 ENSMUST00000202958.2 Gm43280 (from geneSymbol) ENSMUST00000202958.1 uc290wal.1 uc290wal.2 uc290wal.1 uc290wal.2 
ENSMUST00000202959.2 C030017G13Rik ENSMUST00000202959.2 C030017G13Rik (from geneSymbol) AK081233 ENSMUST00000202959.1 uc290vxo.1 uc290vxo.2 uc290vxo.1 uc290vxo.2 
ENSMUST00000202960.2 Gm43231 ENSMUST00000202960.2 Gm43231 (from geneSymbol) ENSMUST00000202960.1 uc290yts.1 uc290yts.2 uc290yts.1 uc290yts.2 
ENSMUST00000202969.2 1700013A02Rik ENSMUST00000202969.2 1700013A02Rik (from geneSymbol) ENSMUST00000202969.1 uc291bxu.1 uc291bxu.2 uc291bxu.1 uc291bxu.2 
ENSMUST00000202970.3 Gm43262 ENSMUST00000202970.3 Gm43262 (from geneSymbol) AK006834 ENSMUST00000202970.1 ENSMUST00000202970.2 uc288mwm.1 uc288mwm.2 uc288mwm.3 uc288mwm.1 uc288mwm.2 uc288mwm.3 
ENSMUST00000202983.2 D630030B08Rik ENSMUST00000202983.2 D630030B08Rik (from geneSymbol) ENSMUST00000202983.1 uc290wcv.1 uc290wcv.2 uc290wcv.1 uc290wcv.2 
ENSMUST00000202985.2 Gm43100 ENSMUST00000202985.2 Gm43100 (from geneSymbol) ENSMUST00000202985.1 uc290wme.1 uc290wme.2 uc290wme.1 uc290wme.2 
ENSMUST00000202986.2 Gm43092 ENSMUST00000202986.2 Gm43092 (from geneSymbol) AK157652 ENSMUST00000202986.1 uc290vid.1 uc290vid.2 uc290vid.1 uc290vid.2 
ENSMUST00000202988.4 Zfp799 ENSMUST00000202988.4 zinc finger protein 799, transcript variant 1 (from RefSeq NM_177359.5) ENSMUST00000202988.1 ENSMUST00000202988.2 ENSMUST00000202988.3 NM_177359 Q8BHK4 Q8BHK4_MOUSE Zfp799 uc008bxo.1 uc008bxo.2 uc008bxo.3 uc008bxo.4 Nucleus molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process metal ion binding uc008bxo.1 uc008bxo.2 uc008bxo.3 uc008bxo.4 
ENSMUST00000202995.2 Gm42867 ENSMUST00000202995.2 Gm42867 (from geneSymbol) BC107408 ENSMUST00000202995.1 uc290urn.1 uc290urn.2 uc290urn.1 uc290urn.2 
ENSMUST00000203013.2 Gm43915 ENSMUST00000203013.2 predicted gene, 43915 (from RefSeq NR_138099.1) ENSMUST00000203013.1 NR_138099 uc291ils.1 uc291ils.2 uc291ils.1 uc291ils.2 
ENSMUST00000203019.2 Gm43947 ENSMUST00000203019.2 Gm43947 (from geneSymbol) ENSMUST00000203019.1 uc291hml.1 uc291hml.2 uc291hml.1 uc291hml.2 
ENSMUST00000203020.3 Tarm1 ENSMUST00000203020.3 T cell-interacting, activating receptor on myeloid cells 1, transcript variant 2 (from RefSeq NM_001362148.1) A0A0N4SVP3 A0A0N4SVP3_MOUSE ENSMUST00000203020.1 ENSMUST00000203020.2 NM_001362148 Tarm1 uc291kod.1 uc291kod.2 uc291kod.1 uc291kod.2 
ENSMUST00000203022.2 Gm44120 ENSMUST00000203022.2 Gm44120 (from geneSymbol) DQ704301 ENSMUST00000203022.1 uc291jju.1 uc291jju.2 uc291jju.1 uc291jju.2 
ENSMUST00000203027.2 9930120I10Rik ENSMUST00000203027.2 9930120I10Rik (from geneSymbol) AK020689 ENSMUST00000203027.1 uc291gru.1 uc291gru.2 uc291gru.1 uc291gru.2 
ENSMUST00000203032.2 Gm44230 ENSMUST00000203032.2 Gm44230 (from geneSymbol) AK079101 ENSMUST00000203032.1 uc291fzg.1 uc291fzg.2 uc291fzg.1 uc291fzg.2 
ENSMUST00000203044.3 Gm44206 ENSMUST00000203044.3 Gm44206 (from geneSymbol) ENSMUST00000203044.1 ENSMUST00000203044.2 uc291iab.1 uc291iab.2 uc291iab.1 uc291iab.2 
ENSMUST00000203047.3 4921529L05Rik ENSMUST00000203047.3 4921529L05Rik (from geneSymbol) AK085171 ENSMUST00000203047.1 ENSMUST00000203047.2 uc033iry.1 uc033iry.2 uc033iry.3 uc033iry.4 uc033iry.1 uc033iry.2 uc033iry.3 uc033iry.4 
ENSMUST00000203049.2 Gm44264 ENSMUST00000203049.2 Gm44264 (from geneSymbol) ENSMUST00000203049.1 uc291gtw.1 uc291gtw.2 uc291gtw.1 uc291gtw.2 
ENSMUST00000203051.2 Gm43881 ENSMUST00000203051.2 Gm43881 (from geneSymbol) AK034917 ENSMUST00000203051.1 uc291ebx.1 uc291ebx.2 uc291ebx.1 uc291ebx.2 
ENSMUST00000203055.2 Gm44021 ENSMUST00000203055.2 Gm44021 (from geneSymbol) ENSMUST00000203055.1 uc291kjn.1 uc291kjn.2 uc291kjn.1 uc291kjn.2 
ENSMUST00000203057.3 ENSMUSG00000121354 ENSMUST00000203057.3 ENSMUSG00000121354 (from geneSymbol) DQ237930 ENSMUST00000203057.1 ENSMUST00000203057.2 uc291jit.1 uc291jit.2 uc291jit.1 uc291jit.2 
ENSMUST00000203062.2 4933439N06Rik ENSMUST00000203062.2 4933439N06Rik (from geneSymbol) ENSMUST00000203062.1 uc291fxh.1 uc291fxh.2 uc291fxh.1 uc291fxh.2 
ENSMUST00000203063.2 Gm44198 ENSMUST00000203063.2 Gm44198 (from geneSymbol) AK155683 ENSMUST00000203063.1 uc291grb.1 uc291grb.2 uc291grb.1 uc291grb.2 
ENSMUST00000203064.2 ENSMUSG00000121364 ENSMUST00000203064.2 ENSMUSG00000121364 (from geneSymbol) ENSMUST00000203064.1 uc291jmt.1 uc291jmt.2 uc291jmt.1 uc291jmt.2 
ENSMUST00000203069.2 Gm44287 ENSMUST00000203069.2 Gm44287 (from geneSymbol) ENSMUST00000203069.1 uc291gdp.1 uc291gdp.2 uc291gdp.1 uc291gdp.2 
ENSMUST00000203074.3 Vwde ENSMUST00000203074.3 von Willebrand factor D and EGF domains, transcript variant 1 (from RefSeq NM_001368871.1) A0A0N4SVZ4 A0A0N4SVZ4_MOUSE ENSMUST00000203074.1 ENSMUST00000203074.2 NM_001368871 Vwde uc291cos.1 uc291cos.2 Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding uc291cos.1 uc291cos.2 
ENSMUST00000203082.3 Fxyd4 ENSMUST00000203082.3 Membrane ; Single-pass type I membrane protein (from UniProt Q9D2W0) BC086918 ENSMUST00000203082.1 ENSMUST00000203082.2 FXYD4_MOUSE Q9D2W0 uc009dlh.1 uc009dlh.2 uc009dlh.3 Membrane ; Single-pass type I membrane protein Belongs to the FXYD family. potassium channel activity sodium:potassium-exchanging ATPase complex ion transport monovalent inorganic cation transport membrane integral component of membrane sodium channel regulator activity regulation of ion transport ATPase binding potassium ion transmembrane transport ion channel regulator activity regulation of sodium ion transmembrane transporter activity uc009dlh.1 uc009dlh.2 uc009dlh.3 
ENSMUST00000203084.2 Gm44270 ENSMUST00000203084.2 Gm44270 (from geneSymbol) AK086979 ENSMUST00000203084.1 uc291kgy.1 uc291kgy.2 uc291kgy.1 uc291kgy.2 
ENSMUST00000203087.2 6330419E04Rik ENSMUST00000203087.2 6330419E04Rik (from geneSymbol) ENSMUST00000203087.1 uc291ebj.1 uc291ebj.2 uc291ebj.1 uc291ebj.2 
ENSMUST00000203092.2 Gm44250 ENSMUST00000203092.2 Gm44250 (from geneSymbol) ENSMUST00000203092.1 LF195329 uc291cjm.1 uc291cjm.2 uc291cjm.1 uc291cjm.2 
ENSMUST00000203093.2 Gm44165 ENSMUST00000203093.2 Gm44165 (from geneSymbol) AK155796 ENSMUST00000203093.1 uc291koe.1 uc291koe.2 uc291koe.1 uc291koe.2 
ENSMUST00000203102.2 Gm44291 ENSMUST00000203102.2 Gm44291 (from geneSymbol) ENSMUST00000203102.1 uc289vsm.1 uc289vsm.2 uc289vsm.1 uc289vsm.2 
ENSMUST00000203106.2 Gm44181 ENSMUST00000203106.2 Gm44181 (from geneSymbol) AK155785 ENSMUST00000203106.1 uc291hga.1 uc291hga.2 uc291hga.1 uc291hga.2 
ENSMUST00000203115.2 4930402H05Rik ENSMUST00000203115.2 4930402H05Rik (from geneSymbol) ENSMUST00000203115.1 uc291hcn.1 uc291hcn.2 uc291hcn.1 uc291hcn.2 
ENSMUST00000203121.3 D830050J10Rik ENSMUST00000203121.3 D830050J10Rik (from geneSymbol) ENSMUST00000203121.1 ENSMUST00000203121.2 uc291hzr.1 uc291hzr.2 uc291hzr.3 uc291hzr.1 uc291hzr.2 uc291hzr.3 
ENSMUST00000203125.2 Gm44380 ENSMUST00000203125.2 Gm44380 (from geneSymbol) AK206573 ENSMUST00000203125.1 uc291chp.1 uc291chp.2 uc291chp.1 uc291chp.2 
ENSMUST00000203139.2 Gm44440 ENSMUST00000203139.2 Gm44440 (from geneSymbol) AK148639 ENSMUST00000203139.1 uc291hnk.1 uc291hnk.2 uc291hnk.1 uc291hnk.2 
ENSMUST00000203141.2 Gm5111 ENSMUST00000203141.2 Gm5111 (from geneSymbol) AK041789 ENSMUST00000203141.1 uc009buu.1 uc009buu.2 uc009buu.3 uc009buu.1 uc009buu.2 uc009buu.3 
ENSMUST00000203145.2 Gm44046 ENSMUST00000203145.2 Gm44046 (from geneSymbol) ENSMUST00000203145.1 uc291clh.1 uc291clh.2 uc291clh.1 uc291clh.2 
ENSMUST00000203149.3 Or2v1 ENSMUST00000203149.3 Odorant receptor. Activated by (+) and (-)-limonene. (from UniProt Q8VGD6) BC147437 ENSMUST00000203149.1 ENSMUST00000203149.2 Mor276-1 OR2V1_MOUSE Olfr56 Or2v1 Q8BKF2 Q8VGD6 Q9QUL1 Q9Z1U2 uc011xua.1 uc011xua.2 uc011xua.3 Odorant receptor. Activated by (+) and (-)-limonene. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 IsoId=Q8VGD6-1; Sequence=Displayed; Name=2 ; IsoId=Q8VGD6-2; Sequence=VSP_046444; Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc011xua.1 uc011xua.2 uc011xua.3 
ENSMUST00000203151.2 Gm44410 ENSMUST00000203151.2 Gm44410 (from geneSymbol) ENSMUST00000203151.1 uc291eyq.1 uc291eyq.2 uc291eyq.1 uc291eyq.2 
ENSMUST00000203153.2 Gm44106 ENSMUST00000203153.2 Gm44106 (from geneSymbol) ENSMUST00000203153.1 LF195955 uc291jvu.1 uc291jvu.2 uc291jvu.1 uc291jvu.2 
ENSMUST00000203158.2 Gm44001 ENSMUST00000203158.2 Gm44001 (from geneSymbol) ENSMUST00000203158.1 uc291gux.1 uc291gux.2 uc291gux.1 uc291gux.2 
ENSMUST00000203175.2 Gm30055 ENSMUST00000203175.2 Gm30055 (from geneSymbol) ENSMUST00000203175.1 uc291jvb.1 uc291jvb.2 uc291jvb.1 uc291jvb.2 
ENSMUST00000203181.2 Gm44170 ENSMUST00000203181.2 Gm44170 (from geneSymbol) ENSMUST00000203181.1 uc291gty.1 uc291gty.2 uc291gty.1 uc291gty.2 
ENSMUST00000203184.2 Gm44065 ENSMUST00000203184.2 Gm44065 (from geneSymbol) ENSMUST00000203184.1 uc291hif.1 uc291hif.2 uc291hif.1 uc291hif.2 
ENSMUST00000203186.2 Gm44005 ENSMUST00000203186.2 Gm44005 (from geneSymbol) AK048727 ENSMUST00000203186.1 uc291guu.1 uc291guu.2 uc291guu.1 uc291guu.2 
ENSMUST00000203187.3 C2cd5 ENSMUST00000203187.3 C2 calcium-dependent domain containing 5, transcript variant 1 (from RefSeq NM_029081.3) C2CD5_MOUSE Cdp138 ENSMUST00000203187.1 ENSMUST00000203187.2 Kiaa0528 NM_029081 Q3TQY6 Q6A052 Q7TPS5 Q80VA1 Q8C0U3 Q8CID5 Q9CS85 uc009epz.1 uc009epz.2 uc009epz.3 uc009epz.4 uc009epz.5 Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per C2 domain. Cytoplasmic vesicle membrane Cytoplasm, cell cortex Cell membrane Cell projection, ruffle Note=Dynamically associated with GLUT4-containing glucose storage vesicles (GSV) and plasma membrane in response to insulin stimulation. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7TPS5-1; Sequence=Displayed; Name=2; IsoId=Q7TPS5-2; Sequence=VSP_019992, VSP_019993; Name=3; IsoId=Q7TPS5-3; Sequence=VSP_019991; Expressed in liver, muscle and fat. The C2 domain binds to calcium and membrane lipids. Phosphorylated on Ser-197 by active myristoylated kinase AKT2; insulin-stimulated phosphorylation by AKT2 regulates SLC2A4/GLUT4 translocation into the plasma membrane. Sequence=BAD32244.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; ruffle calcium ion binding calcium-dependent phospholipid binding cytoplasm microtubule organizing center cytosol plasma membrane cell cortex vesicle fusion lipid binding positive regulation of glucose transport protein transport membrane cytoplasmic vesicle membrane positive regulation of vesicle fusion cytoplasmic vesicle ruffle membrane cellular response to insulin stimulus insulin receptor signaling pathway via phosphatidylinositol 3-kinase cell projection positive regulation of glucose import intracellular protein transmembrane transport protein localization to plasma membrane positive regulation of protein targeting to membrane uc009epz.1 uc009epz.2 uc009epz.3 uc009epz.4 uc009epz.5 
ENSMUST00000203191.3 2900060B14Rik ENSMUST00000203191.3 RIKEN cDNA 2900060B14 gene (from RefSeq NR_027901.1) ENSMUST00000203191.1 ENSMUST00000203191.2 NR_027901 uc007cih.1 uc007cih.2 uc007cih.3 uc007cih.4 uc007cih.5 uc007cih.1 uc007cih.2 uc007cih.3 uc007cih.4 uc007cih.5 
ENSMUST00000203194.2 Gm43906 ENSMUST00000203194.2 Gm43906 (from geneSymbol) ENSMUST00000203194.1 uc291fpv.1 uc291fpv.2 uc291fpv.1 uc291fpv.2 
ENSMUST00000203211.2 Gm44229 ENSMUST00000203211.2 Gm44229 (from geneSymbol) AK045739 ENSMUST00000203211.1 uc291fzj.1 uc291fzj.2 uc291fzj.1 uc291fzj.2 
ENSMUST00000203218.2 Gm43872 ENSMUST00000203218.2 Gm43872 (from geneSymbol) ENSMUST00000203218.1 uc291ebe.1 uc291ebe.2 uc291ebe.1 uc291ebe.2 
ENSMUST00000203230.2 Gm44241 ENSMUST00000203230.2 Gm44241 (from geneSymbol) ENSMUST00000203230.1 uc291fzi.1 uc291fzi.2 uc291fzi.1 uc291fzi.2 
ENSMUST00000203231.2 Gm44017 ENSMUST00000203231.2 Gm44017 (from geneSymbol) ENSMUST00000203231.1 uc291jqx.1 uc291jqx.2 uc291jqx.1 uc291jqx.2 
ENSMUST00000203236.3 Or6c65 ENSMUST00000203236.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGI8) ENSMUST00000203236.1 ENSMUST00000203236.2 Olfr808 Or6c65 Q8VGI8 Q8VGI8_MOUSE uc287vzf.1 uc287vzf.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vzf.1 uc287vzf.2 
ENSMUST00000203242.2 Gm44107 ENSMUST00000203242.2 Gm44107 (from geneSymbol) ENSMUST00000203242.1 uc291hlm.1 uc291hlm.2 uc291hlm.1 uc291hlm.2 
ENSMUST00000203245.2 Gm34933 ENSMUST00000203245.2 Gm34933 (from geneSymbol) ENSMUST00000203245.1 uc291hoq.1 uc291hoq.2 uc291hoq.1 uc291hoq.2 
ENSMUST00000203246.3 4930404I20Rik ENSMUST00000203246.3 4930404I20Rik (from geneSymbol) AK015082 ENSMUST00000203246.1 ENSMUST00000203246.2 uc291jxh.1 uc291jxh.2 uc291jxh.3 uc291jxh.1 uc291jxh.2 uc291jxh.3 
ENSMUST00000203248.3 Or6c5 ENSMUST00000203248.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRI5) ENSMUST00000203248.1 ENSMUST00000203248.2 Olfr774 Or6c5 Q7TRI5 Q7TRI5_MOUSE uc287vxg.1 uc287vxg.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vxg.1 uc287vxg.2 
ENSMUST00000203251.2 Gm44086 ENSMUST00000203251.2 Gm44086 (from geneSymbol) AK089609 ENSMUST00000203251.1 uc291kfq.1 uc291kfq.2 uc291kfq.1 uc291kfq.2 
ENSMUST00000203256.4 Or2t45 ENSMUST00000203256.4 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFG7) A0A0N4SV42 ENSMUST00000203256.1 ENSMUST00000203256.2 ENSMUST00000203256.3 Olfr315 Or2t45 Q8VFG7 Q8VFG7_MOUSE uc287ylc.1 uc287ylc.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ylc.1 uc287ylc.2 
ENSMUST00000203260.2 9430018G01Rik ENSMUST00000203260.2 RIKEN cDNA 9430018G01 gene (from RefSeq NR_045988.1) ENSMUST00000203260.1 NR_045988 uc291ear.1 uc291ear.2 uc291ear.1 uc291ear.2 
ENSMUST00000203270.2 Gm44114 ENSMUST00000203270.2 Gm44114 (from geneSymbol) AK032235 ENSMUST00000203270.1 uc291evf.1 uc291evf.2 uc291evf.1 uc291evf.2 
ENSMUST00000203274.2 Gm43894 ENSMUST00000203274.2 Gm43894 (from geneSymbol) ENSMUST00000203274.1 uc291eza.1 uc291eza.2 uc291eza.1 uc291eza.2 
ENSMUST00000203285.2 Gm43981 ENSMUST00000203285.2 Gm43981 (from geneSymbol) AK150147 ENSMUST00000203285.1 uc291gbi.1 uc291gbi.2 uc291gbi.1 uc291gbi.2 
ENSMUST00000203287.3 Gm44597 ENSMUST00000203287.3 Gm44597 (from geneSymbol) AK141896 ENSMUST00000203287.1 ENSMUST00000203287.2 uc291iya.1 uc291iya.2 uc291iya.1 uc291iya.2 
ENSMUST00000203289.2 Gm43961 ENSMUST00000203289.2 Gm43961 (from geneSymbol) ENSMUST00000203289.1 LF195339 uc291clv.1 uc291clv.2 uc291clv.1 uc291clv.2 
ENSMUST00000203298.2 Gm44417 ENSMUST00000203298.2 Gm44417 (from geneSymbol) AK033877 ENSMUST00000203298.1 uc291gqv.1 uc291gqv.2 uc291gqv.1 uc291gqv.2 
ENSMUST00000203301.2 Gm43966 ENSMUST00000203301.2 Gm43966 (from geneSymbol) ENSMUST00000203301.1 LF195502 uc291eny.1 uc291eny.2 uc291eny.1 uc291eny.2 
ENSMUST00000203304.2 2700052C19Rik ENSMUST00000203304.2 2700052C19Rik (from geneSymbol) AK012412 ENSMUST00000203304.1 uc291knv.1 uc291knv.2 uc291knv.1 uc291knv.2 
ENSMUST00000203306.2 Gm31579 ENSMUST00000203306.2 Gm31579 (from geneSymbol) AK132130 ENSMUST00000203306.1 uc291ekm.1 uc291ekm.2 uc291ekm.1 uc291ekm.2 
ENSMUST00000203312.2 Gm44062 ENSMUST00000203312.2 Gm44062 (from geneSymbol) AK034041 ENSMUST00000203312.1 uc289vtc.1 uc289vtc.2 uc289vtc.1 uc289vtc.2 
ENSMUST00000203319.2 Gm43875 ENSMUST00000203319.2 Gm43875 (from geneSymbol) AK043714 ENSMUST00000203319.1 uc291ebz.1 uc291ebz.2 uc291ebz.1 uc291ebz.2 
ENSMUST00000203342.2 Gm44432 ENSMUST00000203342.2 Gm44432 (from geneSymbol) ENSMUST00000203342.1 uc291cif.1 uc291cif.2 uc291cif.1 uc291cif.2 
ENSMUST00000203350.2 Gm44067 ENSMUST00000203350.2 Gm44067 (from geneSymbol) ENSMUST00000203350.1 uc291jhz.1 uc291jhz.2 uc291jhz.1 uc291jhz.2 
ENSMUST00000203352.2 4933406J09Rik ENSMUST00000203352.2 RIKEN cDNA 4933406J09 gene (from RefSeq NR_153848.1) ENSMUST00000203352.1 NR_153848 uc009ekg.1 uc009ekg.2 uc009ekg.1 uc009ekg.2 
ENSMUST00000203354.2 Gm20371 ENSMUST00000203354.2 Gm20371 (from geneSymbol) AK138350 ENSMUST00000203354.1 uc291fzh.1 uc291fzh.2 uc291fzh.1 uc291fzh.2 
ENSMUST00000203358.2 Gm44142 ENSMUST00000203358.2 Gm44142 (from geneSymbol) ENSMUST00000203358.1 uc291joz.1 uc291joz.2 uc291joz.1 uc291joz.2 
ENSMUST00000203360.2 Gm44040 ENSMUST00000203360.2 Gm44040 (from geneSymbol) ENSMUST00000203360.1 uc291hpr.1 uc291hpr.2 uc291hpr.1 uc291hpr.2 
ENSMUST00000203362.2 Gm43893 ENSMUST00000203362.2 Gm43893 (from geneSymbol) ENSMUST00000203362.1 uc291eyz.1 uc291eyz.2 uc291eyz.1 uc291eyz.2 
ENSMUST00000203364.2 Gm44053 ENSMUST00000203364.2 Gm44053 (from geneSymbol) ENSMUST00000203364.1 uc291hwp.1 uc291hwp.2 uc291hwp.1 uc291hwp.2 
ENSMUST00000203365.3 Zim3 ENSMUST00000203365.3 zinc finger, imprinted 3 (from RefSeq NR_036631.2) ENSMUST00000203365.1 ENSMUST00000203365.2 NR_036631 uc009fcc.1 uc009fcc.2 uc009fcc.3 uc009fcc.4 uc009fcc.1 uc009fcc.2 uc009fcc.3 uc009fcc.4 
ENSMUST00000203368.2 C030015A19Rik ENSMUST00000203368.2 C030015A19Rik (from geneSymbol) AK028820 ENSMUST00000203368.1 uc291haq.1 uc291haq.2 uc291haq.1 uc291haq.2 
ENSMUST00000203372.3 Pde1c ENSMUST00000203372.3 phosphodiesterase 1C, transcript variant 18 (from RefSeq NR_176967.1) A0A0N4SWG4 A0A0N4SWG4_MOUSE ENSMUST00000203372.1 ENSMUST00000203372.2 NR_176967 Pde1c uc291erv.1 uc291erv.2 Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278; Evidence=; Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, ChEBI:CHEBI:58115; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16958; Evidence=; Reaction=a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'- phosphate + H(+); Xref=Rhea:RHEA:14653, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57867, ChEBI:CHEBI:58464; EC=3.1.4.17; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14654; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 3',5'-cyclic-nucleotide phosphodiesterase activity signal transduction phosphoric diester hydrolase activity hydrolase activity metal ion binding uc291erv.1 uc291erv.2 
ENSMUST00000203376.2 Gm44430 ENSMUST00000203376.2 Gm44430 (from geneSymbol) AK043240 ENSMUST00000203376.1 uc291guj.1 uc291guj.2 uc291guj.1 uc291guj.2 
ENSMUST00000203379.2 Gm44439 ENSMUST00000203379.2 Gm44439 (from geneSymbol) AK034158 ENSMUST00000203379.1 uc291hng.1 uc291hng.2 uc291hng.1 uc291hng.2 
ENSMUST00000203386.2 Gm5878 ENSMUST00000203386.2 predicted gene 5878 (from RefSeq NR_168059.1) ENSMUST00000203386.1 NR_168059 uc009cpe.1 uc009cpe.2 uc009cpe.3 uc009cpe.1 uc009cpe.2 uc009cpe.3 
ENSMUST00000203387.2 Gm44253 ENSMUST00000203387.2 Gm44253 (from geneSymbol) ENSMUST00000203387.1 LF204607 uc291eah.1 uc291eah.2 uc291eah.1 uc291eah.2 
ENSMUST00000203389.2 Gm44070 ENSMUST00000203389.2 Gm44070 (from geneSymbol) AB349218 ENSMUST00000203389.1 uc291jon.1 uc291jon.2 uc291jon.1 uc291jon.2 
ENSMUST00000203390.2 9330118I20Rik ENSMUST00000203390.2 9330118I20Rik (from geneSymbol) AK020366 ENSMUST00000203390.1 uc291faa.1 uc291faa.2 uc291faa.1 uc291faa.2 
ENSMUST00000203393.2 9530013L04Rik ENSMUST00000203393.2 9530013L04Rik (from geneSymbol) AK020555 ENSMUST00000203393.1 uc291gqy.1 uc291gqy.2 uc291gqy.1 uc291gqy.2 
ENSMUST00000203396.3 Or2r3 ENSMUST00000203396.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGP5) A0A0N4SV18 ENSMUST00000203396.1 ENSMUST00000203396.2 Olfr457 Or2r3 Q8VGP5 Q8VGP5_MOUSE uc291dyf.1 uc291dyf.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dyf.1 uc291dyf.2 
ENSMUST00000203397.2 Gm10209 ENSMUST00000203397.2 Gm10209 (from geneSymbol) ENSMUST00000203397.1 LF195520 uc291eso.1 uc291eso.2 uc291eso.1 uc291eso.2 
ENSMUST00000203403.3 ENSMUSG00000121382 ENSMUST00000203403.3 ENSMUSG00000121382 (from geneSymbol) AK137189 ENSMUST00000203403.1 ENSMUST00000203403.2 uc011xuo.1 uc011xuo.2 uc011xuo.3 uc011xuo.1 uc011xuo.2 uc011xuo.3 
ENSMUST00000203414.2 Naaladl2 ENSMUST00000203414.2 N-acetylated alpha-linked acidic dipeptidase-like 2 (from RefSeq NM_001326288.1) A0A0N4SUJ3 A0A0N4SUJ3_MOUSE ENSMUST00000203414.1 NM_001326288 Naaladl2 uc057lfn.1 uc057lfn.2 uc057lfn.3 molecular_function nucleoplasm response to bacterium membrane integral component of membrane uc057lfn.1 uc057lfn.2 uc057lfn.3 
ENSMUST00000203417.2 Gm44274 ENSMUST00000203417.2 Gm44274 (from geneSymbol) ENSMUST00000203417.1 uc291jsu.1 uc291jsu.2 uc291jsu.1 uc291jsu.2 
ENSMUST00000203418.4 Or2t46 ENSMUST00000203418.4 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5NCD2) A0A0N4SW60 ENSMUST00000203418.1 ENSMUST00000203418.2 ENSMUST00000203418.3 F8VPQ3 Olfr325 Or2t46 Q5NCD2 Q5NCD2_MOUSE uc007jbu.1 uc007jbu.2 uc007jbu.3 uc007jbu.4 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007jbu.1 uc007jbu.2 uc007jbu.3 uc007jbu.4 
ENSMUST00000203419.2 Gm44027 ENSMUST00000203419.2 Gm44027 (from geneSymbol) ENSMUST00000203419.1 uc289vvf.1 uc289vvf.2 uc289vvf.1 uc289vvf.2 
ENSMUST00000203420.5 Gm5886 ENSMUST00000203420.5 predicted gene 5886, transcript variant non-coding allele (from RefSeq NR_111985.1) ENSMUST00000203420.1 ENSMUST00000203420.2 ENSMUST00000203420.3 ENSMUST00000203420.4 NR_111985 uc057aev.1 uc057aev.2 uc057aev.3 uc057aev.4 uc057aev.5 uc057aev.1 uc057aev.2 uc057aev.3 uc057aev.4 uc057aev.5 
ENSMUST00000203426.2 Gm44043 ENSMUST00000203426.2 Gm44043 (from geneSymbol) ENSMUST00000203426.1 LF285341 uc291kmx.1 uc291kmx.2 uc291kmx.1 uc291kmx.2 
ENSMUST00000203437.2 Gm43890 ENSMUST00000203437.2 Gm43890 (from geneSymbol) ENSMUST00000203437.1 uc291gey.1 uc291gey.2 uc291gey.1 uc291gey.2 
ENSMUST00000203438.2 Gm44424 ENSMUST00000203438.2 Gm44424 (from geneSymbol) AK048495 ENSMUST00000203438.1 uc291cjt.1 uc291cjt.2 uc291cjt.1 uc291cjt.2 
ENSMUST00000203440.2 Gm43896 ENSMUST00000203440.2 Gm43896 (from geneSymbol) AK140927 ENSMUST00000203440.1 uc291ezo.1 uc291ezo.2 uc291ezo.1 uc291ezo.2 
ENSMUST00000203442.2 Gm36582 ENSMUST00000203442.2 predicted gene, 36582 (from RefSeq NR_157238.1) ENSMUST00000203442.1 NR_157238 uc009eln.1 uc009eln.2 uc009eln.3 uc009eln.1 uc009eln.2 uc009eln.3 
ENSMUST00000203443.2 Gm43909 ENSMUST00000203443.2 Gm43909 (from geneSymbol) ENSMUST00000203443.1 LF202684 uc291kfg.1 uc291kfg.2 uc291kfg.1 uc291kfg.2 
ENSMUST00000203449.3 2610300M13Rik ENSMUST00000203449.3 2610300M13Rik (from geneSymbol) AK011946 ENSMUST00000203449.1 ENSMUST00000203449.2 uc291fcq.1 uc291fcq.2 uc291fcq.3 uc291fcq.1 uc291fcq.2 uc291fcq.3 
ENSMUST00000203456.2 Gm44255 ENSMUST00000203456.2 Gm44255 (from geneSymbol) ENSMUST00000203456.1 uc291fyg.1 uc291fyg.2 uc291fyg.1 uc291fyg.2 
ENSMUST00000203464.2 Gm19131 ENSMUST00000203464.2 Gm19131 (from geneSymbol) ENSMUST00000203464.1 uc291ezw.1 uc291ezw.2 uc291ezw.1 uc291ezw.2 
ENSMUST00000203466.2 Gm43963 ENSMUST00000203466.2 Gm43963 (from geneSymbol) AK156975 ENSMUST00000203466.1 uc291hwg.1 uc291hwg.2 uc291hwg.1 uc291hwg.2 
ENSMUST00000203474.2 Gm43948 ENSMUST00000203474.2 Gm43948 (from geneSymbol) AK034226 ENSMUST00000203474.1 uc291hmb.1 uc291hmb.2 uc291hmb.1 uc291hmb.2 
ENSMUST00000203475.2 4930443G03Rik ENSMUST00000203475.2 4930443G03Rik (from geneSymbol) AK015370 ENSMUST00000203475.1 uc291jxi.1 uc291jxi.2 uc291jxi.1 uc291jxi.2 
ENSMUST00000203488.3 Vmn1r21 ENSMUST00000203488.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2C6) A0A0N4SV70 A0A0N4SW70 ENSMUST00000203488.1 ENSMUST00000203488.2 Q8R2C6 Q8R2C6_MOUSE V1rc28 Vmn1r21 uc291eve.1 uc291eve.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291eve.1 uc291eve.2 
ENSMUST00000203495.4 AA545190 ENSMUST00000203495.4 AA545190 (from geneSymbol) ENSMUST00000203495.1 ENSMUST00000203495.2 ENSMUST00000203495.3 uc291cnl.1 uc291cnl.2 uc291cnl.3 uc291cnl.1 uc291cnl.2 uc291cnl.3 
ENSMUST00000203503.2 9530086O07Rik ENSMUST00000203503.2 9530086O07Rik (from geneSymbol) AK083892 ENSMUST00000203503.1 uc291hmj.1 uc291hmj.2 uc291hmj.1 uc291hmj.2 
ENSMUST00000203508.2 Gm44146 ENSMUST00000203508.2 Gm44146 (from geneSymbol) ENSMUST00000203508.1 uc289vtv.1 uc289vtv.2 uc289vtv.1 uc289vtv.2 
ENSMUST00000203509.2 Gimap8 ENSMUST00000203509.2 GTPase, IMAP family member 8, transcript variant 1 (from RefSeq NM_212486.2) ENSMUST00000203509.1 GIMA8_MOUSE Ian9 Imap8 NM_212486 Q3UZ12 Q75N62 uc009bvg.1 uc009bvg.2 uc009bvg.3 This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein is larger than the other gene family members and includes three AIG1 domains (corresponding to the AIG1 protein from Arabidopsis thaliana) whereas other family members have one AIG1 domain. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]. Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. Endoplasmic reticulum Golgi apparatus Mitochondrion Cytoplasm, cytosol Abundantly expressed in the thymus (in thymocytes), spleen (in splenocytes), lymph node, followed by bone marrow and lung. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. nucleotide binding GTP binding cytoplasm mitochondrion endoplasmic reticulum Golgi apparatus cytosol regulation of T cell apoptotic process uc009bvg.1 uc009bvg.2 uc009bvg.3 
ENSMUST00000203510.2 Gm44113 ENSMUST00000203510.2 Gm44113 (from geneSymbol) AK139520 ENSMUST00000203510.1 uc291fxj.1 uc291fxj.2 uc291fxj.1 uc291fxj.2 
ENSMUST00000203511.2 Gm44129 ENSMUST00000203511.2 Gm44129 (from geneSymbol) ENSMUST00000203511.1 uc291coh.1 uc291coh.2 uc291coh.1 uc291coh.2 
ENSMUST00000203521.2 Gm10445 ENSMUST00000203521.2 predicted gene 10445 (from RefSeq NR_046063.1) ENSMUST00000203521.1 NR_046063 uc009cox.1 uc009cox.2 uc009cox.1 uc009cox.2 
ENSMUST00000203528.3 Creb5 ENSMUST00000203528.3 cAMP responsive element binding protein 5, transcript variant 1 (from RefSeq NM_001327821.1) A0A0N4SV71 A0A0N4SV71_MOUSE Creb5 ENSMUST00000203528.1 ENSMUST00000203528.2 NM_001327821 uc057lqj.1 uc057lqj.2 uc057lqj.3 Binds to the cAMP response element and activates transcription. Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1. Nucleus Belongs to the bZIP family. nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated uc057lqj.1 uc057lqj.2 uc057lqj.3 
ENSMUST00000203540.2 Gm44433 ENSMUST00000203540.2 Gm44433 (from geneSymbol) ENSMUST00000203540.1 uc291fxy.1 uc291fxy.2 uc291fxy.1 uc291fxy.2 
ENSMUST00000203566.3 Myadm ENSMUST00000203566.3 myeloid-associated differentiation marker, transcript variant 2 (from RefSeq NM_001093765.1) ENSMUST00000203566.1 ENSMUST00000203566.2 Myadm NM_001093765 Q0VE46 Q0VE46_MOUSE uc009eur.1 uc009eur.2 uc009eur.3 Membrane ; Multi- pass membrane protein Belongs to the MAL family. ruffle negative regulation of protein phosphorylation plasma membrane cell-cell junction negative regulation of gene expression membrane integral component of membrane positive regulation of cell migration negative regulation of actin filament polymerization cortical actin cytoskeleton membrane raft organization negative regulation of heterotypic cell-cell adhesion membrane raft establishment of endothelial barrier protein localization to plasma membrane negative regulation of protein kinase C signaling positive regulation of substrate adhesion-dependent cell spreading uc009eur.1 uc009eur.2 uc009eur.3 
ENSMUST00000203567.2 4933406L23Rik ENSMUST00000203567.2 4933406L23Rik (from geneSymbol) AK016703 ENSMUST00000203567.1 uc291kin.1 uc291kin.2 uc291kin.1 uc291kin.2 
ENSMUST00000203569.2 Gm43935 ENSMUST00000203569.2 Gm43935 (from geneSymbol) AK047583 ENSMUST00000203569.1 uc291hti.1 uc291hti.2 uc291hti.1 uc291hti.2 
ENSMUST00000203570.3 Gm43964 ENSMUST00000203570.3 Gm43964 (from geneSymbol) ENSMUST00000203570.1 ENSMUST00000203570.2 uc291hwd.1 uc291hwd.2 uc291hwd.3 uc291hwd.1 uc291hwd.2 uc291hwd.3 
ENSMUST00000203572.4 Zim2 ENSMUST00000203572.4 zinc finger, imprinted 2 (from RefSeq NR_131759.1) ENSMUST00000203572.1 ENSMUST00000203572.2 ENSMUST00000203572.3 NR_131759 uc009fbu.1 uc009fbu.2 uc009fbu.3 uc009fbu.1 uc009fbu.2 uc009fbu.3 
ENSMUST00000203581.3 Rfc1 ENSMUST00000203581.3 replication factor C (activator 1) 1, transcript variant 5 (from RefSeq NM_001421209.1) ENSMUST00000203581.1 ENSMUST00000203581.2 G3UWX1 G3UWX1_MOUSE NM_001421209 Rfc1 uc008xnk.1 uc008xnk.2 uc008xnk.3 uc008xnk.4 uc008xnk.5 Nucleus Belongs to the activator 1 large subunit family. nucleotide binding DNA binding DNA clamp loader activity ATP binding nucleus DNA replication factor C complex DNA replication DNA repair uc008xnk.1 uc008xnk.2 uc008xnk.3 uc008xnk.4 uc008xnk.5 
ENSMUST00000203586.2 Spin2g ENSMUST00000203586.2 Belongs to the SPIN/STSY family. (from UniProt A0A0N4SW15) A0A0N4SW15 A0A0N4SW15_MOUSE ENSMUST00000203586.1 Spin2g uc292nra.1 uc292nra.2 Belongs to the SPIN/STSY family. nucleoplasm cytosol gamete generation biological_process methylated histone binding uc292nra.1 uc292nra.2 
ENSMUST00000203592.2 Gm43914 ENSMUST00000203592.2 Gm43914 (from geneSymbol) ENSMUST00000203592.1 uc291jjj.1 uc291jjj.2 uc291jjj.1 uc291jjj.2 
ENSMUST00000203601.4 ENSMUSG00000121359 ENSMUST00000203601.4 ENSMUSG00000121359 (from geneSymbol) BC116400 ENSMUST00000203601.1 ENSMUST00000203601.2 ENSMUST00000203601.3 uc291jlj.1 uc291jlj.2 uc291jlj.3 uc291jlj.1 uc291jlj.2 uc291jlj.3 
ENSMUST00000203605.2 Gm44164 ENSMUST00000203605.2 Gm44164 (from geneSymbol) AK037291 ENSMUST00000203605.1 uc291keo.1 uc291keo.2 uc291keo.1 uc291keo.2 
ENSMUST00000203619.3 Cntn3 ENSMUST00000203619.3 Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity). (from UniProt Q07409) AK140747 CNTN3_MOUSE ENSMUST00000203619.1 ENSMUST00000203619.2 G5E878 Pang Pcs Q07409 uc291hmw.1 uc291hmw.2 Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity). Interacts with PTPRG. Cell membrane ; Lipid-anchor, GPI- anchor Specifically expressed in brain. Ectopically expressed in tumors expressing endogenous intracisternal A-type particles (IAPs). Belongs to the immunoglobulin superfamily. Contactin family. plasma membrane cell adhesion nervous system development membrane anchored component of membrane uc291hmw.1 uc291hmw.2 
ENSMUST00000203624.2 Gm44089 ENSMUST00000203624.2 Gm44089 (from geneSymbol) AK138207 ENSMUST00000203624.1 uc291gmv.1 uc291gmv.2 uc291gmv.1 uc291gmv.2 
ENSMUST00000203631.2 Gm44265 ENSMUST00000203631.2 Gm44265 (from geneSymbol) ENSMUST00000203631.1 LF195687 uc291gtu.1 uc291gtu.2 uc291gtu.1 uc291gtu.2 
ENSMUST00000203633.3 Etfbl ENSMUST00000203633.3 The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). (from UniProt A0A0N4SVE0) A0A0N4SVE0 A0A0N4SVE0_MOUSE BC069877 ENSMUST00000203633.1 ENSMUST00000203633.2 Etfbl Gm45233 uc291ozn.1 uc291ozn.2 The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Heterodimer of an alpha and a beta subunit. Mitochondrion matrix Belongs to the ETF beta-subunit/FixA family. electron carrier activity electron transport chain uc291ozn.1 uc291ozn.2 
ENSMUST00000203635.2 Gm43880 ENSMUST00000203635.2 Gm43880 (from geneSymbol) AK140649 ENSMUST00000203635.1 uc291ebm.1 uc291ebm.2 uc291ebm.1 uc291ebm.2 
ENSMUST00000203640.2 Gm16523 ENSMUST00000203640.2 predicted gene, 16523 (from RefSeq NR_033526.1) ENSMUST00000203640.1 NR_033526 uc012bvb.1 uc012bvb.2 uc012bvb.1 uc012bvb.2 
ENSMUST00000203642.2 Gm44441 ENSMUST00000203642.2 Gm44441 (from geneSymbol) ENSMUST00000203642.1 uc291hni.1 uc291hni.2 uc291hni.1 uc291hni.2 
ENSMUST00000203645.2 Gm45738 ENSMUST00000203645.2 Gm45738 (from geneSymbol) ENSMUST00000203645.1 uc291eee.1 uc291eee.2 uc291eee.1 uc291eee.2 
ENSMUST00000203660.2 Gm44414 ENSMUST00000203660.2 Gm44414 (from geneSymbol) AK047950 ENSMUST00000203660.1 uc291gqz.1 uc291gqz.2 uc291gqz.1 uc291gqz.2 
ENSMUST00000203666.2 Gm44072 ENSMUST00000203666.2 Gm44072 (from geneSymbol) ENSMUST00000203666.1 uc291faf.1 uc291faf.2 uc291faf.1 uc291faf.2 
ENSMUST00000203679.2 4930480K02Rik ENSMUST00000203679.2 4930480K02Rik (from geneSymbol) AK015601 ENSMUST00000203679.1 uc291jve.1 uc291jve.2 uc291jve.1 uc291jve.2 
ENSMUST00000203683.2 Gm44144 ENSMUST00000203683.2 Gm44144 (from geneSymbol) ENSMUST00000203683.1 uc289vtz.1 uc289vtz.2 uc289vtz.1 uc289vtz.2 
ENSMUST00000203699.2 Gm44033 ENSMUST00000203699.2 Gm44033 (from geneSymbol) AB347189 ENSMUST00000203699.1 uc291hwo.1 uc291hwo.2 uc291hwo.1 uc291hwo.2 
ENSMUST00000203700.3 Or13a1 ENSMUST00000203700.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGH2) ENSMUST00000203700.1 ENSMUST00000203700.2 Olfr211 Or13a1 Q8VGH2 Q8VGH2_MOUSE uc291idj.1 uc291idj.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291idj.1 uc291idj.2 
ENSMUST00000203701.2 Gm44171 ENSMUST00000203701.2 Gm44171 (from geneSymbol) AK050931 ENSMUST00000203701.1 uc291hmo.1 uc291hmo.2 uc291hmo.1 uc291hmo.2 
ENSMUST00000203702.2 4933412L11Rik ENSMUST00000203702.2 4933412L11Rik (from geneSymbol) ENSMUST00000203702.1 LF195683 uc291gtb.1 uc291gtb.2 uc291gtb.1 uc291gtb.2 
ENSMUST00000203708.2 Gm44022 ENSMUST00000203708.2 Gm44022 (from geneSymbol) ENSMUST00000203708.1 uc291kjo.1 uc291kjo.2 uc291kjo.1 uc291kjo.2 
ENSMUST00000203709.2 Gm43953 ENSMUST00000203709.2 Gm43953 (from geneSymbol) ENSMUST00000203709.1 uc291hmk.1 uc291hmk.2 uc291hmk.1 uc291hmk.2 
ENSMUST00000203718.4 Gm44148 ENSMUST00000203718.4 Gm44148 (from geneSymbol) ENSMUST00000203718.1 ENSMUST00000203718.2 ENSMUST00000203718.3 uc291imo.1 uc291imo.2 uc291imo.3 uc291imo.4 uc291imo.1 uc291imo.2 uc291imo.3 uc291imo.4 
ENSMUST00000203746.2 Gm44423 ENSMUST00000203746.2 Gm44423 (from geneSymbol) ENSMUST00000203746.1 uc291grt.1 uc291grt.2 uc291grt.1 uc291grt.2 
ENSMUST00000203764.2 Gm30557 ENSMUST00000203764.2 Gm30557 (from geneSymbol) ENSMUST00000203764.1 uc291ify.1 uc291ify.2 uc291ify.1 uc291ify.2 
ENSMUST00000203765.2 Gm43952 ENSMUST00000203765.2 Gm43952 (from geneSymbol) AK158701 ENSMUST00000203765.1 uc291jqu.1 uc291jqu.2 uc291jqu.1 uc291jqu.2 
ENSMUST00000203769.2 Vsig10l ENSMUST00000203769.2 V-set and immunoglobulin domain containing 10 like, transcript variant 2 (from RefSeq NM_001290316.2) A0A0N4SUI1 A0A0N4SUI1_MOUSE ENSMUST00000203769.1 NM_001290316 Vsig10l uc009gmu.1 uc009gmu.2 uc009gmu.3 uc009gmu.4 nucleus nucleoplasm membrane integral component of membrane uc009gmu.1 uc009gmu.2 uc009gmu.3 uc009gmu.4 
ENSMUST00000203779.2 Gm43965 ENSMUST00000203779.2 Gm43965 (from geneSymbol) ENSMUST00000203779.1 uc291jgc.1 uc291jgc.2 uc291jgc.1 uc291jgc.2 
ENSMUST00000203781.2 Gm38811 ENSMUST00000203781.2 Gm38811 (from geneSymbol) AK031323 ENSMUST00000203781.1 uc291elo.1 uc291elo.2 uc291elo.1 uc291elo.2 
ENSMUST00000203784.2 Gm44220 ENSMUST00000203784.2 Gm44220 (from geneSymbol) ENSMUST00000203784.1 uc291hfy.1 uc291hfy.2 uc291hfy.1 uc291hfy.2 
ENSMUST00000203790.2 Gm43990 ENSMUST00000203790.2 Gm43990 (from geneSymbol) ENSMUST00000203790.1 uc291cql.1 uc291cql.2 uc291cql.1 uc291cql.2 
ENSMUST00000203798.2 ENSMUSG00000121686 ENSMUST00000203798.2 ENSMUSG00000121686 (from geneSymbol) ENSMUST00000203798.1 uc291hli.1 uc291hli.2 uc291hli.1 uc291hli.2 
ENSMUST00000203807.2 Gm45901 ENSMUST00000203807.2 Gm45901 (from geneSymbol) ENSMUST00000203807.1 uc291hba.1 uc291hba.2 uc291hba.1 uc291hba.2 
ENSMUST00000203809.2 Gm43994 ENSMUST00000203809.2 Gm43994 (from geneSymbol) ENSMUST00000203809.1 uc291ewa.1 uc291ewa.2 uc291ewa.1 uc291ewa.2 
ENSMUST00000203811.2 Gm43879 ENSMUST00000203811.2 Gm43879 (from geneSymbol) ENSMUST00000203811.1 uc291ebd.1 uc291ebd.2 uc291ebd.1 uc291ebd.2 
ENSMUST00000203815.2 Gm32914 ENSMUST00000203815.2 Gm32914 (from geneSymbol) BC023705 ENSMUST00000203815.1 uc291kfl.1 uc291kfl.2 uc291kfl.1 uc291kfl.2 
ENSMUST00000203817.3 1700013D24Rik ENSMUST00000203817.3 1700013D24Rik (from geneSymbol) BC120816 ENSMUST00000203817.1 ENSMUST00000203817.2 uc291ism.1 uc291ism.2 uc291ism.3 uc291ism.1 uc291ism.2 uc291ism.3 
ENSMUST00000203819.2 Gm44136 ENSMUST00000203819.2 Gm44136 (from geneSymbol) AK084353 ENSMUST00000203819.1 uc290ewd.1 uc290ewd.2 uc290ewd.1 uc290ewd.2 
ENSMUST00000203822.2 Gm43863 ENSMUST00000203822.2 Gm43863 (from geneSymbol) AK132802 ENSMUST00000203822.1 uc291ifj.1 uc291ifj.2 uc291ifj.1 uc291ifj.2 
ENSMUST00000203823.2 Gm57774 ENSMUST00000203823.2 Gm57774 (from geneSymbol) ENSMUST00000203823.1 uc291jmr.1 uc291jmr.2 uc291jmr.1 uc291jmr.2 
ENSMUST00000203831.2 Gm43876 ENSMUST00000203831.2 Gm43876 (from geneSymbol) ENSMUST00000203831.1 uc291ebn.1 uc291ebn.2 uc291ebn.1 uc291ebn.2 
ENSMUST00000203832.2 Gm44437 ENSMUST00000203832.2 Gm44437 (from geneSymbol) AK047037 ENSMUST00000203832.1 uc291fye.1 uc291fye.2 uc291fye.1 uc291fye.2 
ENSMUST00000203836.2 Gm44284 ENSMUST00000203836.2 Gm44284 (from geneSymbol) AK081414 ENSMUST00000203836.1 uc009bqx.1 uc009bqx.2 uc009bqx.1 uc009bqx.2 
ENSMUST00000203839.3 ENSMUSG00000121366 ENSMUST00000203839.3 ENSMUSG00000121366 (from geneSymbol) ENSMUST00000203839.1 ENSMUST00000203839.2 uc291jns.1 uc291jns.2 uc291jns.1 uc291jns.2 
ENSMUST00000203845.2 Gm44007 ENSMUST00000203845.2 Gm44007 (from geneSymbol) AK052218 ENSMUST00000203845.1 uc291iso.1 uc291iso.2 uc291iso.1 uc291iso.2 
ENSMUST00000203856.2 Gm19692 ENSMUST00000203856.2 Gm19692 (from geneSymbol) ENSMUST00000203856.1 uc291hlt.1 uc291hlt.2 uc291hlt.1 uc291hlt.2 
ENSMUST00000203859.2 1700102F20Rik ENSMUST00000203859.2 1700102F20Rik (from geneSymbol) AK007111 ENSMUST00000203859.1 uc291jyi.1 uc291jyi.2 uc291jyi.1 uc291jyi.2 
ENSMUST00000203868.2 Gm43930 ENSMUST00000203868.2 Gm43930 (from geneSymbol) ENSMUST00000203868.1 uc291iee.1 uc291iee.2 uc291iee.1 uc291iee.2 
ENSMUST00000203871.3 Gm44110 ENSMUST00000203871.3 Gm44110 (from geneSymbol) ENSMUST00000203871.1 ENSMUST00000203871.2 uc291fqf.1 uc291fqf.2 uc291fqf.3 uc291fqf.1 uc291fqf.2 uc291fqf.3 
ENSMUST00000203875.2 Gm44247 ENSMUST00000203875.2 Gm44247 (from geneSymbol) ENSMUST00000203875.1 uc291jpv.1 uc291jpv.2 uc291jpv.1 uc291jpv.2 
ENSMUST00000203883.3 Oaz3 ENSMUST00000203883.3 Belongs to the ODC antizyme family. (from UniProt A0A0N4SWE3) A0A0N4SWE3 A0A0N4SWE3_MOUSE AB045835 ENSMUST00000203883.1 ENSMUST00000203883.2 Oaz3 uc290hik.1 uc290hik.2 Belongs to the ODC antizyme family. spermatogenesis ornithine decarboxylase inhibitor activity negative regulation of catalytic activity uc290hik.1 uc290hik.2 
ENSMUST00000203887.3 Or6c201 ENSMUST00000203887.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGC2) A0A0N4SV47 A0A0N4SV56 ENSMUST00000203887.1 ENSMUST00000203887.2 Olfr770 Or6c201 Q8VGC2 Q8VGC2_MOUSE uc287vxa.1 uc287vxa.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vxa.1 uc287vxa.2 
ENSMUST00000203894.2 Gm43866 ENSMUST00000203894.2 Gm43866 (from geneSymbol) ENSMUST00000203894.1 uc291iaw.1 uc291iaw.2 uc291iaw.1 uc291iaw.2 
ENSMUST00000203902.2 4930518I17Rik ENSMUST00000203902.2 4930518I17Rik (from geneSymbol) AK015828 ENSMUST00000203902.1 uc288xkr.1 uc288xkr.2 uc288xkr.1 uc288xkr.2 
ENSMUST00000203903.2 Gm44172 ENSMUST00000203903.2 Gm44172 (from geneSymbol) AK145794 ENSMUST00000203903.1 uc291fqn.1 uc291fqn.2 uc291fqn.1 uc291fqn.2 
ENSMUST00000203905.2 4933431M02Rik ENSMUST00000203905.2 4933431M02Rik (from geneSymbol) AK017013 ENSMUST00000203905.1 uc291hou.1 uc291hou.2 uc291hou.1 uc291hou.2 
ENSMUST00000203906.3 Or7a41 ENSMUST00000203906.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGU7) ENSMUST00000203906.1 ENSMUST00000203906.2 Olfr1351 Olfr57 Or7a41 Q8VGU7 Q8VGU7_MOUSE uc287src.1 uc287src.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287src.1 uc287src.2 
ENSMUST00000203909.3 Gm30731 ENSMUST00000203909.3 predicted gene, 30731 (from RefSeq NR_131335.1) ENSMUST00000203909.1 ENSMUST00000203909.2 NR_131335 uc057brm.1 uc057brm.2 uc057brm.3 uc057brm.1 uc057brm.2 uc057brm.3 
ENSMUST00000203918.2 Gm44434 ENSMUST00000203918.2 Gm44434 (from geneSymbol) AK034279 ENSMUST00000203918.1 uc291env.1 uc291env.2 uc291env.1 uc291env.2 
ENSMUST00000203919.3 Gm2011 ENSMUST00000203919.3 predicted gene 2011 (from RefSeq NR_160689.1) ENSMUST00000203919.1 ENSMUST00000203919.2 NR_160689 uc290evz.1 uc290evz.2 uc290evz.1 uc290evz.2 
ENSMUST00000203920.2 Gm10400 ENSMUST00000203920.2 predicted gene 10400 (from RefSeq NR_033555.1) ENSMUST00000203920.1 NR_033555 uc012evf.1 uc012evf.2 uc012evf.1 uc012evf.2 
ENSMUST00000203924.2 Gm43913 ENSMUST00000203924.2 Gm43913 (from geneSymbol) AK082007 ENSMUST00000203924.1 uc291kkq.1 uc291kkq.2 uc291kkq.1 uc291kkq.2 
ENSMUST00000203927.2 Gm4640 ENSMUST00000203927.2 Gm4640 (from geneSymbol) AK012749 ENSMUST00000203927.1 uc291iei.1 uc291iei.2 uc291iei.1 uc291iei.2 
ENSMUST00000203932.3 4732416N19Rik ENSMUST00000203932.3 4732416N19Rik (from geneSymbol) AK028613 ENSMUST00000203932.1 ENSMUST00000203932.2 uc057byv.1 uc057byv.2 uc057byv.3 uc057byv.4 uc057byv.1 uc057byv.2 uc057byv.3 uc057byv.4 
ENSMUST00000203945.3 Kcnj8 ENSMUST00000203945.3 potassium inwardly-rectifying channel, subfamily J, member 8, transcript variant 1 (from RefSeq NM_008428.5) ENSMUST00000203945.1 ENSMUST00000203945.2 Kcnj8 NM_008428 Q3U118 Q3U118_MOUSE uc009epk.1 uc009epk.2 uc009epk.3 Membrane ulti-pass membrane protein Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. kidney development inward rectifier potassium channel activity voltage-gated ion channel activity ATP binding mitochondrion ion transport potassium ion transport ATP-sensitive potassium channel complex ATP-activated inward rectifier potassium channel activity membrane integral component of membrane sulfonylurea receptor binding regulation of ion transmembrane transport sarcolemma intracellular membrane-bounded organelle potassium ion import across plasma membrane uc009epk.1 uc009epk.2 uc009epk.3 
ENSMUST00000203950.2 Gm43889 ENSMUST00000203950.2 Gm43889 (from geneSymbol) ENSMUST00000203950.1 uc291ebg.1 uc291ebg.2 uc291ebg.1 uc291ebg.2 
ENSMUST00000203951.2 Gm44101 ENSMUST00000203951.2 Gm44101 (from geneSymbol) ENSMUST00000203951.1 LF195770 uc291hpn.1 uc291hpn.2 uc291hpn.1 uc291hpn.2 
ENSMUST00000203953.2 B230112I24Rik ENSMUST00000203953.2 B230112I24Rik (from geneSymbol) AK020969 ENSMUST00000203953.1 uc291ebc.1 uc291ebc.2 uc291ebc.1 uc291ebc.2 
ENSMUST00000203956.2 2010008C14Rik ENSMUST00000203956.2 2010008C14Rik (from geneSymbol) AK008157 ENSMUST00000203956.1 uc291iyp.1 uc291iyp.2 uc291iyp.1 uc291iyp.2 
ENSMUST00000203963.2 9530085L11Rik ENSMUST00000203963.2 9530085L11Rik (from geneSymbol) AK035677 ENSMUST00000203963.1 uc291yix.1 uc291yix.2 uc291yix.1 uc291yix.2 
ENSMUST00000203964.2 Gm44183 ENSMUST00000203964.2 Gm44183 (from geneSymbol) AK135872 ENSMUST00000203964.1 uc289vth.1 uc289vth.2 uc289vth.1 uc289vth.2 
ENSMUST00000203966.3 Or6c75 ENSMUST00000203966.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRI0) ENSMUST00000203966.1 ENSMUST00000203966.2 Olfr790 Or6c75 Q7TRI0 Q7TRI0_MOUSE uc007hqa.1 uc007hqa.2 uc007hqa.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hqa.1 uc007hqa.2 uc007hqa.3 
ENSMUST00000203968.3 Prss47 ENSMUST00000203968.3 Prss47 (from geneSymbol) A0A0N4SVQ0 A0A0N4SVQ0_MOUSE ENSMUST00000203968.1 ENSMUST00000203968.2 Prss47 uc288nxi.1 uc288nxi.2 serine-type endopeptidase activity proteolysis uc288nxi.1 uc288nxi.2 
ENSMUST00000203985.2 Gm44026 ENSMUST00000203985.2 Gm44026 (from geneSymbol) AK052497 ENSMUST00000203985.1 uc291epy.1 uc291epy.2 uc291epy.1 uc291epy.2 
ENSMUST00000203986.2 Gm43997 ENSMUST00000203986.2 Gm43997 (from geneSymbol) ENSMUST00000203986.1 uc291hha.1 uc291hha.2 uc291hha.1 uc291hha.2 
ENSMUST00000203992.2 Gm43923 ENSMUST00000203992.2 Gm43923 (from geneSymbol) ENSMUST00000203992.1 uc291hfx.1 uc291hfx.2 uc291hfx.1 uc291hfx.2 
ENSMUST00000203998.2 Gm38804 ENSMUST00000203998.2 Gm38804 (from geneSymbol) ENSMUST00000203998.1 uc291egc.1 uc291egc.2 uc291egc.1 uc291egc.2 
ENSMUST00000204002.2 Gm43883 ENSMUST00000204002.2 Gm43883 (from geneSymbol) ENSMUST00000204002.1 uc291ecd.1 uc291ecd.2 uc291ecd.1 uc291ecd.2 
ENSMUST00000204003.2 Duxf1 ENSMUST00000204003.2 Nucleus (from UniProt A0A0N4SUK1) A0A0N4SUK1 A0A0N4SUK1_MOUSE AW822073 ENSMUST00000204003.1 LF197999 uc287rix.1 uc287rix.2 Nucleus DNA binding nucleus uc287rix.1 uc287rix.2 
ENSMUST00000204006.3 Jkampl ENSMUST00000204006.3 JNK1/MAPK8 associated membrane protein like (from RefSeq NM_025737.4) 4931417E11Rik ENSMUST00000204006.1 ENSMUST00000204006.2 Jkampl NM_025737 Q9CR05 Q9CR05_MOUSE uc291fwx.1 uc291fwx.2 uc291fwx.3 molecular_function cellular_component response to unfolded protein biological_process membrane integral component of membrane uc291fwx.1 uc291fwx.2 uc291fwx.3 
ENSMUST00000204009.3 Or6b2b ENSMUST00000204009.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQS4) ENSMUST00000204009.1 ENSMUST00000204009.2 Olfr1415 Or6b2b Q7TQS4 Q7TQS4_MOUSE uc287klz.1 uc287klz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287klz.1 uc287klz.2 
ENSMUST00000204015.2 Gm44240 ENSMUST00000204015.2 Gm44240 (from geneSymbol) AK045381 ENSMUST00000204015.1 uc291fze.1 uc291fze.2 uc291fze.1 uc291fze.2 
ENSMUST00000204031.2 Gm44102 ENSMUST00000204031.2 Gm44102 (from geneSymbol) ENSMUST00000204031.1 uc291hja.1 uc291hja.2 uc291hja.1 uc291hja.2 
ENSMUST00000204036.2 Gimap3 ENSMUST00000204036.2 GTPase, IMAP family member 3 (from RefSeq NM_031247.3) ENSMUST00000204036.1 GIMA3_MOUSE Ian4 NM_031247 Q4VBX0 Q549W4 Q8CF04 Q99MI6 uc009bvt.1 uc009bvt.2 This gene encodes a mitochondrial membrane protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The expression of this gene is induced in BCR/ABL-expressing cells. The encoded protein lacks an N-terminal mitochondrial signal sequence. Experimental studies showed that mitochondrial localization relies on the C-terminal transmembrane domain. In humans, the IAN subfamily genes are located in a cluster at 7q36.1 [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AF337052.1, AB164418.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## During thymocyte development, may support the positive selection of CD4 and CD8 T cells (PubMed:16509771). May play a role in mitochondrial DNA segregation in hematopoietic tissues (PubMed:25808953). Binds GTP (PubMed:11238997). Interacts with BAD, BAK1, BAX, BCL2, BCL2L1/Bcl-xL and BCL2L11/BimEL (PubMed:16509771). The interaction with BAX is increased, when cells initiate apoptosis upon IL2 withdrawal (PubMed:16509771). Q99MI6; P10417: Bcl2; NbExp=4; IntAct=EBI-15572304, EBI-526314; Q99MI6; Q07812: BAX; Xeno; NbExp=2; IntAct=EBI-15572304, EBI-516580; Q99MI6; Q07817-1: BCL2L1; Xeno; NbExp=3; IntAct=EBI-15572304, EBI-287195; Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Note=The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications. Expressed in thymus (in thymocytes), spleen (in splenocytes), lymph node and, at lower levels, in lung (PubMed:16509771, PubMed:25808953). Highly expressed in T lymphocytes (PubMed:16509771). Up-regulated upon the maturation of CD4/CD8 double-positive to CD4 single-positive thymocytes. By BCR-ABL oncogene. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. Sequence=AAK31138.1; Type=Frameshift; Evidence=; nucleotide binding protein binding GTP binding mitochondrion mitochondrial outer membrane endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane mitochondrial DNA inheritance uc009bvt.1 uc009bvt.2 
ENSMUST00000204049.2 Gm44068 ENSMUST00000204049.2 Gm44068 (from geneSymbol) ENSMUST00000204049.1 uc291kcv.1 uc291kcv.2 uc291kcv.1 uc291kcv.2 
ENSMUST00000204055.2 Gm44416 ENSMUST00000204055.2 Gm44416 (from geneSymbol) ENSMUST00000204055.1 uc291gqt.1 uc291gqt.2 uc291gqt.1 uc291gqt.2 
ENSMUST00000204058.2 Gm43946 ENSMUST00000204058.2 Gm43946 (from geneSymbol) AK086960 ENSMUST00000204058.1 uc291hmm.1 uc291hmm.2 uc291hmm.1 uc291hmm.2 
ENSMUST00000204059.3 Add2 ENSMUST00000204059.3 adducin 2, transcript variant 2 (from RefSeq NM_001271858.1) ADDB_MOUSE ENSMUST00000204059.1 ENSMUST00000204059.2 NM_001271858 Q3U0E1 Q80VH9 Q8C1C4 Q9CXE3 Q9JLE4 Q9JLE5 Q9QYB7 Q9QYB8 uc009crf.1 uc009crf.2 uc009crf.3 uc009crf.4 This gene encodes the beta subunit of the adducin family. Adducins, encoded by alpha, beta and gamma genes, are heteromeric proteins that crosslink actin filaments with spectrin at the cytoskeletal membrane. This protein, primarily found in the brain and hematopoietic cells, is regulated by phosphorylation and calmodulin interactions as it promotes spectrin assembly onto actin filaments, bundles actin and caps barbed ends of actin filaments. In mouse, deficiency of this gene can lead to mild hemolytic anemia and impaired synaptic plasticity. Mutations of this gene in mouse serve as a pathophysiological model for hereditary spherocytosis and hereditary elliptocytosis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]. Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). Found in a complex with ADD2, DMTN and SLC2A1. Interacts with SLC2A1 (By similarity). Heterodimer of an alpha and a beta subunit. Cytoplasm, cytoskeleton Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9QYB8-1; Sequence=Displayed; Name=2; IsoId=Q9QYB8-2; Sequence=VSP_000184, VSP_000185; Name=3; Synonyms=Delta; IsoId=Q9QYB8-3; Sequence=VSP_022596; Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region. Belongs to the aldolase class II family. Adducin subfamily. actin binding structural constituent of cytoskeleton calmodulin binding cytoplasm cytoskeleton plasma membrane ion transport synapse assembly F-actin capping protein complex postsynaptic density membrane protein kinase binding hemopoiesis spectrin binding cytoplasmic vesicle positive regulation of protein binding protein homodimerization activity plasma membrane raft protein heterodimerization activity leukocyte migration leukocyte tethering or rolling actin filament binding barbed-end actin filament capping actin filament bundle assembly macromolecular complex assembly postsynapse glutamatergic synapse uc009crf.1 uc009crf.2 uc009crf.3 uc009crf.4 
ENSMUST00000204063.3 Gm32591 ENSMUST00000204063.3 Gm32591 (from geneSymbol) ENSMUST00000204063.1 ENSMUST00000204063.2 uc291gav.1 uc291gav.2 uc291gav.1 uc291gav.2 
ENSMUST00000204070.2 Gm44166 ENSMUST00000204070.2 Gm44166 (from geneSymbol) ENSMUST00000204070.1 uc291fxq.1 uc291fxq.2 uc291fxq.1 uc291fxq.2 
ENSMUST00000204075.2 Gm44445 ENSMUST00000204075.2 Gm44445 (from geneSymbol) AK089651 ENSMUST00000204075.1 uc291enu.1 uc291enu.2 uc291enu.1 uc291enu.2 
ENSMUST00000204079.2 1700097M23Rik ENSMUST00000204079.2 1700097M23Rik (from geneSymbol) AK076915 ENSMUST00000204079.1 uc009ckg.1 uc009ckg.2 uc009ckg.3 uc009ckg.1 uc009ckg.2 uc009ckg.3 
ENSMUST00000204082.3 Gm44278 ENSMUST00000204082.3 Gm44278 (from geneSymbol) ENSMUST00000204082.1 ENSMUST00000204082.2 uc291hce.1 uc291hce.2 uc291hce.3 uc291hce.1 uc291hce.2 uc291hce.3 
ENSMUST00000204092.3 Or2a56 ENSMUST00000204092.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFS6) ENSMUST00000204092.1 ENSMUST00000204092.2 Olfr441 Olfr444 Or2a56 Q8VFS6 Q8VFS6_MOUSE uc009bsd.1 uc009bsd.2 uc009bsd.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009bsd.1 uc009bsd.2 uc009bsd.3 
ENSMUST00000204095.3 Zfp775 ENSMUST00000204095.3 zinc finger protein 775 (from RefSeq NM_173429.3) ENSMUST00000204095.1 ENSMUST00000204095.2 NM_173429 Q8BI73 ZN775_MOUSE Znf775 uc009bvc.1 uc009bvc.2 uc009bvc.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus biological_process metal ion binding uc009bvc.1 uc009bvc.2 uc009bvc.3 
ENSMUST00000204098.2 Gm44286 ENSMUST00000204098.2 Gm44286 (from geneSymbol) AK142910 ENSMUST00000204098.1 uc291fyb.1 uc291fyb.2 uc291fyb.1 uc291fyb.2 
ENSMUST00000204101.2 Gm31108 ENSMUST00000204101.2 predicted gene, 31108 (from RefSeq NR_153819.1) ENSMUST00000204101.1 NR_153819 uc009eqd.1 uc009eqd.2 uc009eqd.1 uc009eqd.2 
ENSMUST00000204105.2 Dnai7 ENSMUST00000204105.2 Belongs to the DNAI7 family. (from UniProt A0A0N4SUQ9) A0A0N4SUQ9 A0A0N4SUQ9_MOUSE BC144801 Casc1 Dnai7 ENSMUST00000204105.1 uc012evo.1 uc012evo.2 uc012evo.3 Belongs to the DNAI7 family. uc012evo.1 uc012evo.2 uc012evo.3 
ENSMUST00000204106.2 Gm44231 ENSMUST00000204106.2 Gm44231 (from geneSymbol) ENSMUST00000204106.1 LF227613 uc291fzl.1 uc291fzl.2 uc291fzl.1 uc291fzl.2 
ENSMUST00000204108.3 Or6c35 ENSMUST00000204108.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFZ8) ENSMUST00000204108.1 ENSMUST00000204108.2 Olfr781 Or6c35 Q8VFZ8 Q8VFZ8_MOUSE uc287vxp.1 uc287vxp.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vxp.1 uc287vxp.2 
ENSMUST00000204118.2 Gm44186 ENSMUST00000204118.2 Gm44186 (from geneSymbol) AK035567 ENSMUST00000204118.1 uc291fqo.1 uc291fqo.2 uc291fqo.1 uc291fqo.2 
ENSMUST00000204121.2 Gm44965 ENSMUST00000204121.2 Gm44965 (from geneSymbol) A0A0N4SVR3 A0A0N4SVR3_MOUSE BC092301 ENSMUST00000204121.1 Gm44965 uc291efy.1 uc291efy.2 uc291efy.1 uc291efy.2 
ENSMUST00000204123.3 Gm44427 ENSMUST00000204123.3 Gm44427 (from geneSymbol) ENSMUST00000204123.1 ENSMUST00000204123.2 uc291fpz.1 uc291fpz.2 uc291fpz.3 uc291fpz.1 uc291fpz.2 uc291fpz.3 
ENSMUST00000204124.2 Gm7298 ENSMUST00000204124.2 Monomer. (from UniProt A0A0N4SVU1) A0A0N4SVU1 A0A0N4SVU1_MOUSE ENSMUST00000204124.1 Gm7298 uc291ink.1 uc291ink.2 Monomer. Secreted Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. protease binding endopeptidase inhibitor activity extracellular region extracellular space negative regulation of endopeptidase activity uc291ink.1 uc291ink.2 
ENSMUST00000204128.3 Galntl6 ENSMUST00000204128.3 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6 (from RefSeq NM_175032.4) E5D8G1 E5D8G1_MOUSE ENSMUST00000204128.1 ENSMUST00000204128.2 Galntl6 NM_175032 uc012gea.1 uc012gea.2 uc012gea.3 uc012gea.4 Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= Protein modification; protein glycosylation. Golgi apparatus membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Golgi membrane polypeptide N-acetylgalactosaminyltransferase activity Golgi apparatus protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via threonine carbohydrate binding uc012gea.1 uc012gea.2 uc012gea.3 uc012gea.4 
ENSMUST00000204131.2 Gm44224 ENSMUST00000204131.2 Gm44224 (from geneSymbol) ENSMUST00000204131.1 uc291hfv.1 uc291hfv.2 uc291hfv.1 uc291hfv.2 
ENSMUST00000204132.2 Gm44267 ENSMUST00000204132.2 Gm44267 (from geneSymbol) AK198190 ENSMUST00000204132.1 uc291jxe.1 uc291jxe.2 uc291jxe.1 uc291jxe.2 
ENSMUST00000204137.3 Gm44790 ENSMUST00000204137.3 Gm44790 (from geneSymbol) A0A0N4SV91 A0A0N4SV91_MOUSE BC025632 ENSMUST00000204137.1 ENSMUST00000204137.2 Gm44790 uc291gom.1 uc291gom.2 uc291gom.3 uc291gom.1 uc291gom.2 uc291gom.3 
ENSMUST00000204148.2 Gm44371 ENSMUST00000204148.2 Gm44371 (from geneSymbol) ENSMUST00000204148.1 uc291jfr.1 uc291jfr.2 uc291jfr.1 uc291jfr.2 
ENSMUST00000204151.2 Gm44415 ENSMUST00000204151.2 Gm44415 (from geneSymbol) AK143842 ENSMUST00000204151.1 uc291gqr.1 uc291gqr.2 uc291gqr.1 uc291gqr.2 
ENSMUST00000204153.2 Gm44214 ENSMUST00000204153.2 Gm44214 (from geneSymbol) ENSMUST00000204153.1 uc291gpi.1 uc291gpi.2 uc291gpi.1 uc291gpi.2 
ENSMUST00000204154.2 Gm44012 ENSMUST00000204154.2 Gm44012 (from geneSymbol) ENSMUST00000204154.1 uc291gjk.1 uc291gjk.2 uc291gjk.1 uc291gjk.2 
ENSMUST00000204155.2 Gm49058 ENSMUST00000204155.2 Gm49058 (from geneSymbol) ENSMUST00000204155.1 uc291kli.1 uc291kli.2 uc291kli.1 uc291kli.2 
ENSMUST00000204159.2 Gm44124 ENSMUST00000204159.2 Gm44124 (from geneSymbol) AF307450 ENSMUST00000204159.1 uc291iko.1 uc291iko.2 uc291iko.1 uc291iko.2 
ENSMUST00000204162.2 Gm44153 ENSMUST00000204162.2 Gm44153 (from geneSymbol) ENSMUST00000204162.1 uc291gpv.1 uc291gpv.2 uc291gpv.1 uc291gpv.2 
ENSMUST00000204173.2 Gm44073 ENSMUST00000204173.2 Gm44073 (from geneSymbol) ENSMUST00000204173.1 uc291erk.1 uc291erk.2 uc291erk.1 uc291erk.2 
ENSMUST00000204181.2 Gm10415 ENSMUST00000204181.2 predicted gene 10415 (from RefSeq NR_045480.1) ENSMUST00000204181.1 NR_045480 uc029vyq.1 uc029vyq.2 uc029vyq.1 uc029vyq.2 
ENSMUST00000204186.2 Gm44196 ENSMUST00000204186.2 Gm44196 (from geneSymbol) AK020861 ENSMUST00000204186.1 uc291hjl.1 uc291hjl.2 uc291hjl.1 uc291hjl.2 
ENSMUST00000204189.3 Tra2a ENSMUST00000204189.3 transformer 2 alpha, transcript variant 47 (from RefSeq NM_001406161.1) A0A0N4SVC2 A0A0N4SVC2_MOUSE ENSMUST00000204189.1 ENSMUST00000204189.2 NM_001406161 Tra2a uc009bwm.1 uc009bwm.2 uc009bwm.3 nucleic acid binding RNA binding uc009bwm.1 uc009bwm.2 uc009bwm.3 
ENSMUST00000204192.2 Gm44039 ENSMUST00000204192.2 Gm44039 (from geneSymbol) ENSMUST00000204192.1 uc291cqf.1 uc291cqf.2 uc291cqf.1 uc291cqf.2 
ENSMUST00000204195.2 Gm44192 ENSMUST00000204195.2 Gm44192 (from geneSymbol) AK029577 ENSMUST00000204195.1 uc291hqu.1 uc291hqu.2 uc291hqu.1 uc291hqu.2 
ENSMUST00000204197.2 Pthlh ENSMUST00000204197.2 Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath. (from UniProt Q924X4) BC058187 ENSMUST00000204197.1 Pthlh Q924X4 Q924X4_MOUSE uc291kig.1 uc291kig.2 Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath. Osteostatin is a potent inhibitor of osteoclastic bone resorption. PTHrP interacts with PTH1R (via N-terminal extracellular domain). Cytoplasm Nucleus Secreted There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. Belongs to the parathyroid hormone family. skeletal system development hormone activity extracellular region nucleoplasm Golgi apparatus cytosol adenylate cyclase-activating G-protein coupled receptor signaling pathway regulation of gene expression bone mineralization negative regulation of chondrocyte differentiation peptide hormone receptor binding negative regulation of chondrocyte development uc291kig.1 uc291kig.2 
ENSMUST00000204200.2 Gm44436 ENSMUST00000204200.2 Gm44436 (from geneSymbol) AK148711 ENSMUST00000204200.1 uc291hnl.1 uc291hnl.2 uc291hnl.1 uc291hnl.2 
ENSMUST00000204212.2 Gm44242 ENSMUST00000204212.2 Gm44242 (from geneSymbol) ENSMUST00000204212.1 uc291fzk.1 uc291fzk.2 uc291fzk.1 uc291fzk.2 
ENSMUST00000204213.2 ENSMUSG00000121626 ENSMUST00000204213.2 ENSMUSG00000121626 (from geneSymbol) AK136670 ENSMUST00000204213.1 uc291dwu.1 uc291dwu.2 uc291dwu.1 uc291dwu.2 
ENSMUST00000204215.2 6330415B21Rik ENSMUST00000204215.2 RIKEN cDNA 6330415B21 gene (from RefSeq NR_045141.1) ENSMUST00000204215.1 NR_045141 uc291fxw.1 uc291fxw.2 uc291fxw.1 uc291fxw.2 
ENSMUST00000204216.2 Gm44941 ENSMUST00000204216.2 Gm44941 (from geneSymbol) ENSMUST00000204216.1 uc291gnh.1 uc291gnh.2 uc291gnh.1 uc291gnh.2 
ENSMUST00000204219.2 Gm44418 ENSMUST00000204219.2 Gm44418 (from geneSymbol) ENSMUST00000204219.1 uc291gqw.1 uc291gqw.2 uc291gqw.1 uc291gqw.2 
ENSMUST00000204220.2 D030044L04Rik ENSMUST00000204220.2 D030044L04Rik (from geneSymbol) AK083557 ENSMUST00000204220.1 uc291ief.1 uc291ief.2 uc291ief.1 uc291ief.2 
ENSMUST00000204221.2 Gm30332 ENSMUST00000204221.2 predicted gene, 30332 (from RefSeq NR_126082.1) ENSMUST00000204221.1 NR_126082 uc009eno.1 uc009eno.2 uc009eno.1 uc009eno.2 
ENSMUST00000204222.2 Gm44194 ENSMUST00000204222.2 Gm44194 (from geneSymbol) ENSMUST00000204222.1 uc291fqr.1 uc291fqr.2 uc291fqr.1 uc291fqr.2 
ENSMUST00000204223.2 Gm44596 ENSMUST00000204223.2 Gm44596 (from geneSymbol) A0A0N4SVA0 A0A0N4SVA0_MOUSE BC115523 ENSMUST00000204223.1 Gm44596 uc291jgb.1 uc291jgb.2 uc291jgb.1 uc291jgb.2 
ENSMUST00000204224.3 Suclg2 ENSMUST00000204224.3 succinate-Coenzyme A ligase, GDP-forming, beta subunit, transcript variant 6 (from RefSeq NR_177069.1) ENSMUST00000204224.1 ENSMUST00000204224.2 NR_177069 Q3T9B8 Q3TJQ5 Q3TK63 Q66JT3 Q7TMY3 Q80VV1 Q8K2K9 Q9Z2I8 SUCB2_MOUSE Suclg2 uc009daa.1 uc009daa.2 uc009daa.3 uc009daa.4 uc009daa.5 GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Reaction=CoA + GTP + succinate = GDP + phosphate + succinyl-CoA; Xref=Rhea:RHEA:22120, ChEBI:CHEBI:30031, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:58189; EC=6.2.1.4; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP. Mitochondrion Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z2I8-1; Sequence=Displayed; Name=2; IsoId=Q9Z2I8-2; Sequence=VSP_016905; Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily. nucleotide binding magnesium ion binding catalytic activity succinate-CoA ligase activity succinate-CoA ligase (ADP-forming) activity succinate-CoA ligase (GDP-forming) activity succinate-semialdehyde dehydrogenase (NAD+) activity ATP binding GTP binding mitochondrion plasma membrane tricarboxylic acid cycle succinyl-CoA metabolic process succinate metabolic process ligase activity GDP binding macromolecular complex succinate-CoA ligase complex succinate-CoA ligase complex (GDP-forming) metal ion binding protein heterodimerization activity uc009daa.1 uc009daa.2 uc009daa.3 uc009daa.4 uc009daa.5 
ENSMUST00000204231.2 Gm44141 ENSMUST00000204231.2 Gm44141 (from geneSymbol) ENSMUST00000204231.1 uc291ede.1 uc291ede.2 uc291ede.1 uc291ede.2 
ENSMUST00000204240.3 1700069P05Rik ENSMUST00000204240.3 RIKEN cDNA 1700069P05 gene (from RefSeq NR_040527.1) ENSMUST00000204240.1 ENSMUST00000204240.2 NR_040527 uc029vyg.1 uc029vyg.2 uc029vyg.3 uc029vyg.4 uc029vyg.1 uc029vyg.2 uc029vyg.3 uc029vyg.4 
ENSMUST00000204242.3 Rps4l ENSMUST00000204242.3 ribosomal protein S4-like (from RefSeq NR_003634.2) ENSMUST00000204242.1 ENSMUST00000204242.2 NR_003634 Q3V1Z5 Q3V1Z5_MOUSE Rps4l Rps4y2 uc291kjl.1 uc291kjl.2 uc291kjl.3 Belongs to the eukaryotic ribosomal protein eS4 family. RNA binding structural constituent of ribosome ribosome translation rRNA binding uc291kjl.1 uc291kjl.2 uc291kjl.3 
ENSMUST00000204244.2 Gm26911 ENSMUST00000204244.2 Gm26911 (from geneSymbol) AK081199 ENSMUST00000204244.1 uc291hmh.1 uc291hmh.2 uc291hmh.1 uc291hmh.2 
ENSMUST00000204246.2 Gm44234 ENSMUST00000204246.2 Gm44234 (from geneSymbol) ENSMUST00000204246.1 uc291fxv.1 uc291fxv.2 uc291fxv.1 uc291fxv.2 
ENSMUST00000204247.2 Gm44087 ENSMUST00000204247.2 Gm44087 (from geneSymbol) AB349884 ENSMUST00000204247.1 uc291kfu.1 uc291kfu.2 uc291kfu.1 uc291kfu.2 
ENSMUST00000204251.2 Gm43884 ENSMUST00000204251.2 Gm43884 (from geneSymbol) AK081777 ENSMUST00000204251.1 uc291ebl.1 uc291ebl.2 uc291ebl.1 uc291ebl.2 
ENSMUST00000204260.2 Gpnmb ENSMUST00000204260.2 Belongs to the PMEL/NMB family. (from UniProt Q8BVA0) AK079220 ENSMUST00000204260.1 Gpnmb Q8BVA0 Q8BVA0_MOUSE uc291eie.1 uc291eie.2 Belongs to the PMEL/NMB family. membrane integral component of membrane uc291eie.1 uc291eie.2 
ENSMUST00000204262.2 Gm44321 ENSMUST00000204262.2 Gm44321 (from geneSymbol) ENSMUST00000204262.1 uc291fqd.1 uc291fqd.2 uc291fqd.1 uc291fqd.2 
ENSMUST00000204269.2 Gm44116 ENSMUST00000204269.2 Gm44116 (from geneSymbol) ENSMUST00000204269.1 LF195757 uc291hlp.1 uc291hlp.2 uc291hlp.1 uc291hlp.2 
ENSMUST00000204274.2 6820426E19Rik ENSMUST00000204274.2 RIKEN cDNA 6820426E19 gene (from RefSeq NR_152214.1) ENSMUST00000204274.1 NR_152214 uc009dkv.1 uc009dkv.2 uc009dkv.1 uc009dkv.2 
ENSMUST00000204284.2 Gm36503 ENSMUST00000204284.2 Gm36503 (from geneSymbol) AK144227 ENSMUST00000204284.1 uc291cqr.1 uc291cqr.2 uc291cqr.1 uc291cqr.2 
ENSMUST00000204285.3 Zfp964 ENSMUST00000204285.3 zinc finger protein 964 (from RefSeq NM_001177527.1) B2RR88 B2RR88_MOUSE EG636741 ENSMUST00000204285.1 ENSMUST00000204285.2 Gm7187 NM_001177527 Zfp964 uc012gem.1 uc012gem.2 uc012gem.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc012gem.1 uc012gem.2 uc012gem.3 
ENSMUST00000204286.2 Gm43999 ENSMUST00000204286.2 Gm43999 (from geneSymbol) ENSMUST00000204286.1 uc291guv.1 uc291guv.2 uc291guv.1 uc291guv.2 
ENSMUST00000204295.2 E330037G11Rik ENSMUST00000204295.2 E330037G11Rik (from geneSymbol) ENSMUST00000204295.1 uc291yiu.1 uc291yiu.2 uc291yiu.1 uc291yiu.2 
ENSMUST00000204296.2 Gm43921 ENSMUST00000204296.2 Gm43921 (from geneSymbol) ENSMUST00000204296.1 LF195324 uc291chw.1 uc291chw.2 uc291chw.1 uc291chw.2 
ENSMUST00000204297.2 5730507A11Rik ENSMUST00000204297.2 5730507A11Rik (from geneSymbol) AK020490 ENSMUST00000204297.1 uc289vua.1 uc289vua.2 uc289vua.1 uc289vua.2 
ENSMUST00000204312.2 Gm44235 ENSMUST00000204312.2 Gm44235 (from geneSymbol) ENSMUST00000204312.1 uc291fxz.1 uc291fxz.2 uc291fxz.1 uc291fxz.2 
ENSMUST00000204314.3 Gm44317 ENSMUST00000204314.3 Gm44317 (from geneSymbol) AK029583 ENSMUST00000204314.1 ENSMUST00000204314.2 uc291ihv.1 uc291ihv.2 uc291ihv.3 uc291ihv.1 uc291ihv.2 uc291ihv.3 
ENSMUST00000204323.2 Gm44243 ENSMUST00000204323.2 Gm44243 (from geneSymbol) ENSMUST00000204323.1 LF195924 uc291jjz.1 uc291jjz.2 uc291jjz.1 uc291jjz.2 
ENSMUST00000204330.2 Gm19434 ENSMUST00000204330.2 predicted gene, 19434 (from RefSeq NR_040296.1) ENSMUST00000204330.1 NR_040296 uc029wcf.1 uc029wcf.2 uc029wcf.3 uc029wcf.1 uc029wcf.2 uc029wcf.3 
ENSMUST00000204333.2 Mmrn1 ENSMUST00000204333.2 multimerin 1, transcript variant 2 (from RefSeq NM_001163507.1) A0A0N4SVL8 A0A0N4SVL8_MOUSE ENSMUST00000204333.1 Mmrn1 NM_001163507 uc012emu.1 uc012emu.2 uc012emu.3 Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding blood coagulation uc012emu.1 uc012emu.2 uc012emu.3 
ENSMUST00000204338.2 Gm44177 ENSMUST00000204338.2 Gm44177 (from geneSymbol) ENSMUST00000204338.1 uc291hmt.1 uc291hmt.2 uc291hmt.1 uc291hmt.2 
ENSMUST00000204345.2 Gm44008 ENSMUST00000204345.2 Gm44008 (from geneSymbol) BC116194 ENSMUST00000204345.1 uc291eqm.1 uc291eqm.2 uc291eqm.1 uc291eqm.2 
ENSMUST00000204346.2 Gm43970 ENSMUST00000204346.2 Gm43970 (from geneSymbol) ENSMUST00000204346.1 uc289vvs.1 uc289vvs.2 uc289vvs.1 uc289vvs.2 
ENSMUST00000204347.3 Magi1 ENSMUST00000204347.3 membrane associated guanylate kinase, WW and PDZ domain containing 1, transcript variant 6 (from RefSeq NM_001286785.2) A0A0N4SUZ0 A0A0N4SUZ0_MOUSE ENSMUST00000204347.1 ENSMUST00000204347.2 Magi1 NM_001286785 uc009czl.1 uc009czl.2 uc009czl.3 uc009czl.4 Membrane ; Peripheral membrane protein bicellular tight junction binding, bridging uc009czl.1 uc009czl.2 uc009czl.3 uc009czl.4 
ENSMUST00000204350.2 Gm44388 ENSMUST00000204350.2 Gm44388 (from geneSymbol) AK028085 ENSMUST00000204350.1 uc291gtn.1 uc291gtn.2 uc291gtn.1 uc291gtn.2 
ENSMUST00000204352.2 Gm43912 ENSMUST00000204352.2 Gm43912 (from geneSymbol) ENSMUST00000204352.1 LF195802 uc291hwh.1 uc291hwh.2 uc291hwh.1 uc291hwh.2 
ENSMUST00000204358.2 Gm43992 ENSMUST00000204358.2 Gm43992 (from geneSymbol) AK138351 ENSMUST00000204358.1 uc291jiq.1 uc291jiq.2 uc291jiq.1 uc291jiq.2 
ENSMUST00000204360.2 Gm43958 ENSMUST00000204360.2 Gm43958 (from geneSymbol) AK083858 ENSMUST00000204360.1 uc291jzh.1 uc291jzh.2 uc291jzh.1 uc291jzh.2 
ENSMUST00000204364.2 Gm44103 ENSMUST00000204364.2 Gm44103 (from geneSymbol) AK133346 ENSMUST00000204364.1 uc291icb.1 uc291icb.2 uc291icb.1 uc291icb.2 
ENSMUST00000204366.2 ENSMUSG00000121699 ENSMUST00000204366.2 ENSMUSG00000121699 (from geneSymbol) AF037047 ENSMUST00000204366.1 uc291fbl.1 uc291fbl.2 uc291fbl.1 uc291fbl.2 
ENSMUST00000204379.2 Gm44435 ENSMUST00000204379.2 Gm44435 (from geneSymbol) ENSMUST00000204379.1 uc291fxx.1 uc291fxx.2 uc291fxx.1 uc291fxx.2 
ENSMUST00000204381.2 Gm44093 ENSMUST00000204381.2 Gm44093 (from geneSymbol) ENSMUST00000204381.1 uc291gpy.1 uc291gpy.2 uc291gpy.1 uc291gpy.2 
ENSMUST00000204387.2 Gm44189 ENSMUST00000204387.2 Gm44189 (from geneSymbol) ENSMUST00000204387.1 uc291hmx.1 uc291hmx.2 uc291hmx.1 uc291hmx.2 
ENSMUST00000204388.2 Gm44438 ENSMUST00000204388.2 Gm44438 (from geneSymbol) AK142100 ENSMUST00000204388.1 uc291fya.1 uc291fya.2 uc291fya.1 uc291fya.2 
ENSMUST00000204392.2 Gm44013 ENSMUST00000204392.2 Gm44013 (from geneSymbol) AK032933 ENSMUST00000204392.1 uc291jyu.1 uc291jyu.2 uc291jyu.1 uc291jyu.2 
ENSMUST00000204395.2 Gm45061 ENSMUST00000204395.2 Gm45061 (from geneSymbol) ENSMUST00000204395.1 uc291eya.1 uc291eya.2 uc291eya.1 uc291eya.2 
ENSMUST00000204396.2 Gm44443 ENSMUST00000204396.2 Gm44443 (from geneSymbol) ENSMUST00000204396.1 EU234051 uc289vsk.1 uc289vsk.2 uc289vsk.1 uc289vsk.2 
ENSMUST00000204401.2 Gm44105 ENSMUST00000204401.2 Gm44105 (from geneSymbol) ENSMUST00000204401.1 uc291hbq.1 uc291hbq.2 uc291hbq.1 uc291hbq.2 
ENSMUST00000204402.3 Or6c5b ENSMUST00000204402.3 olfactory receptor family 6 subfamily C member 5B (from RefSeq NM_001305430.1) A0A0N4SVC3 A0A0N4SVC3_MOUSE ENSMUST00000204402.1 ENSMUST00000204402.2 NM_001305430 Olfr785 Or6c5b uc056yjb.1 uc056yjb.2 uc056yjb.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Apr 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on orthologous data. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc056yjb.1 uc056yjb.2 uc056yjb.3 
ENSMUST00000204405.2 Gm43888 ENSMUST00000204405.2 Gm43888 (from geneSymbol) AK084002 ENSMUST00000204405.1 uc291ebt.1 uc291ebt.2 uc291ebt.1 uc291ebt.2 
ENSMUST00000204406.3 Gm44081 ENSMUST00000204406.3 Gm44081 (from geneSymbol) ENSMUST00000204406.1 ENSMUST00000204406.2 uc291hrn.1 uc291hrn.2 uc291hrn.3 uc291hrn.1 uc291hrn.2 uc291hrn.3 
ENSMUST00000204407.2 Gm5112 ENSMUST00000204407.2 Gm5112 (from geneSymbol) ENSMUST00000204407.1 uc291iqa.1 uc291iqa.2 uc291iqa.1 uc291iqa.2 
ENSMUST00000204412.3 6430584L05Rik ENSMUST00000204412.3 RIKEN cDNA 6430584L05 gene (from RefSeq NR_046179.1) ENSMUST00000204412.1 ENSMUST00000204412.2 NR_046179 uc029vvn.1 uc029vvn.2 uc029vvn.3 uc029vvn.1 uc029vvn.2 uc029vvn.3 
ENSMUST00000204419.2 Gm45140 ENSMUST00000204419.2 Nucleus (from UniProt A0A0N4SUM8) A0A0N4SUM8 A0A0N4SUM8_MOUSE AK158283 ENSMUST00000204419.1 Gm45140 uc291grp.1 uc291grp.2 Nucleus Belongs to the ISY1 family. generation of catalytic spliceosome for second transesterification step mRNA 3'-splice site recognition Prp19 complex catalytic step 2 spliceosome post-mRNA release spliceosomal complex post-spliceosomal complex first spliceosomal transesterification activity uc291grp.1 uc291grp.2 
ENSMUST00000204422.2 ENSMUSG00000121299 ENSMUST00000204422.2 ENSMUSG00000121299 (from geneSymbol) BC087904 ENSMUST00000204422.1 uc012ekx.1 uc012ekx.2 uc012ekx.3 uc012ekx.1 uc012ekx.2 uc012ekx.3 
ENSMUST00000204423.3 Gm44511 ENSMUST00000204423.3 Membrane ; Single- pass type II membrane protein (from UniProt A0A0N4SW10) A0A0N4SW10 A0A0N4SW10_MOUSE AF354260 ENSMUST00000204423.1 ENSMUST00000204423.2 Gm44511 uc291jhs.1 uc291jhs.2 Membrane ; Single- pass type II membrane protein membrane integral component of membrane carbohydrate binding uc291jhs.1 uc291jhs.2 
ENSMUST00000204425.2 Gm3961 ENSMUST00000204425.2 Gm3961 (from geneSymbol) AK038723 ENSMUST00000204425.1 uc291jyh.1 uc291jyh.2 uc291jyh.1 uc291jyh.2 
ENSMUST00000204426.2 1700051K13Rik ENSMUST00000204426.2 1700051K13Rik (from geneSymbol) AK006761 ENSMUST00000204426.1 uc291jqi.1 uc291jqi.2 uc291jqi.1 uc291jqi.2 
ENSMUST00000204436.3 Krcc1 ENSMUST00000204436.3 lysine-rich coiled-coil 1, transcript variant 2 (from RefSeq NM_001354706.1) ENSMUST00000204436.1 ENSMUST00000204436.2 KRCC1_MOUSE NM_001354706 Q99JT5 uc009cgm.1 uc009cgm.2 uc009cgm.3 uc009cgm.1 uc009cgm.2 uc009cgm.3 
ENSMUST00000204442.2 Gm44117 ENSMUST00000204442.2 Gm44117 (from geneSymbol) AK039685 ENSMUST00000204442.1 uc291hav.1 uc291hav.2 uc291hav.1 uc291hav.2 
ENSMUST00000204444.2 4933440N22Rik ENSMUST00000204444.2 4933440N22Rik (from geneSymbol) AK017138 ENSMUST00000204444.1 uc291iff.1 uc291iff.2 uc291iff.1 uc291iff.2 
ENSMUST00000204451.2 Gm44080 ENSMUST00000204451.2 Gm44080 (from geneSymbol) ENSMUST00000204451.1 uc291eoy.1 uc291eoy.2 uc291eoy.1 uc291eoy.2 
ENSMUST00000204452.2 Gm43864 ENSMUST00000204452.2 Gm43864 (from geneSymbol) ENSMUST00000204452.1 uc291eyt.1 uc291eyt.2 uc291eyt.1 uc291eyt.2 
ENSMUST00000204461.2 Gm44283 ENSMUST00000204461.2 Gm44283 (from geneSymbol) AK088595 ENSMUST00000204461.1 uc008jnj.1 uc008jnj.2 uc008jnj.3 uc008jnj.1 uc008jnj.2 uc008jnj.3 
ENSMUST00000204462.2 Gm44401 ENSMUST00000204462.2 Gm44401 (from geneSymbol) AK028669 ENSMUST00000204462.1 uc291juf.1 uc291juf.2 uc291juf.1 uc291juf.2 
ENSMUST00000204474.2 Gm44428 ENSMUST00000204474.2 Gm44428 (from geneSymbol) AK084624 ENSMUST00000204474.1 uc291keu.1 uc291keu.2 uc291keu.1 uc291keu.2 
ENSMUST00000204477.5 Or10b1 ENSMUST00000204477.5 olfactory receptor family 10 subfamily B member 1 (from RefSeq NM_001370810.1) A0A2I3BRV4 A0A2I3BRV4_MOUSE ENSMUST00000204477.1 ENSMUST00000204477.2 ENSMUST00000204477.3 ENSMUST00000204477.4 NM_001370810 Olfr1358 Or10b1 uc287spw.1 uc287spw.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB172978.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287spw.1 uc287spw.2 
ENSMUST00000204484.3 Zfp862-ps ENSMUST00000204484.3 zinc finger protein 862, pseudogene, transcript variant 1 (from RefSeq NR_027808.1) ENSMUST00000204484.1 ENSMUST00000204484.2 NR_027808 uc009bun.1 uc009bun.2 uc009bun.3 uc009bun.4 uc009bun.1 uc009bun.2 uc009bun.3 uc009bun.4 
ENSMUST00000204490.2 4833403J16Rik ENSMUST00000204490.2 4833403J16Rik (from geneSymbol) AK014653 ENSMUST00000204490.1 uc291egz.1 uc291egz.2 uc291egz.1 uc291egz.2 
ENSMUST00000204491.4 Gm30784 ENSMUST00000204491.4 Gm30784 (from geneSymbol) ENSMUST00000204491.1 ENSMUST00000204491.2 ENSMUST00000204491.3 uc291jzv.1 uc291jzv.2 uc291jzv.3 uc291jzv.4 uc291jzv.1 uc291jzv.2 uc291jzv.3 uc291jzv.4 
ENSMUST00000204492.2 Gm44236 ENSMUST00000204492.2 Gm44236 (from geneSymbol) ENSMUST00000204492.1 uc291hbc.1 uc291hbc.2 uc291hbc.1 uc291hbc.2 
ENSMUST00000204498.2 Gm44280 ENSMUST00000204498.2 Gm44280 (from geneSymbol) AK030059 ENSMUST00000204498.1 uc291hun.1 uc291hun.2 uc291hun.1 uc291hun.2 
ENSMUST00000204501.2 Gm44379 ENSMUST00000204501.2 Gm44379 (from geneSymbol) AK180294 ENSMUST00000204501.1 uc291cho.1 uc291cho.2 uc291cho.1 uc291cho.2 
ENSMUST00000204503.2 4930447C11Rik ENSMUST00000204503.2 4930447C11Rik (from geneSymbol) AK015398 ENSMUST00000204503.1 uc291khg.1 uc291khg.2 uc291khg.1 uc291khg.2 
ENSMUST00000204505.2 Gm43873 ENSMUST00000204505.2 Gm43873 (from geneSymbol) ENSMUST00000204505.1 uc291ebr.1 uc291ebr.2 uc291ebr.1 uc291ebr.2 
ENSMUST00000204515.3 Or6c63-ps1 ENSMUST00000204515.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BQH9) A0A2I3BQH9 A0A2I3BQH9_MOUSE ENSMUST00000204515.1 ENSMUST00000204515.2 Or6c63-ps1 uc287vwu.1 uc287vwu.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vwu.1 uc287vwu.2 
ENSMUST00000204518.3 Or2y1c ENSMUST00000204518.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQT0) ENSMUST00000204518.1 ENSMUST00000204518.2 Olfr1386 Or2y1c Q7TQT0 Q7TQT0_MOUSE uc287xty.1 uc287xty.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xty.1 uc287xty.2 
ENSMUST00000204521.2 Gm45021 ENSMUST00000204521.2 Gm45021 (from geneSymbol) A0A1Y7VHP7 A0A1Y7VHP7_MOUSE AK041789 ENSMUST00000204521.1 Gm45021 uc291efu.1 uc291efu.2 uc291efu.1 uc291efu.2 
ENSMUST00000204522.2 Gm43942 ENSMUST00000204522.2 Gm43942 (from geneSymbol) ENSMUST00000204522.1 uc291hmc.1 uc291hmc.2 uc291hmc.1 uc291hmc.2 
ENSMUST00000204525.2 Gm44271 ENSMUST00000204525.2 Gm44271 (from geneSymbol) AK132683 ENSMUST00000204525.1 uc291fyx.1 uc291fyx.2 uc291fyx.1 uc291fyx.2 
ENSMUST00000204529.3 Or6c1b ENSMUST00000204529.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFH8) ENSMUST00000204529.1 ENSMUST00000204529.2 Olfr786 Or6c1b Q8VFH8 Q8VFH8_MOUSE uc287vxt.1 uc287vxt.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vxt.1 uc287vxt.2 
ENSMUST00000204530.2 Eif4a3l1 ENSMUST00000204530.2 eukaryotic translation initiation factor 4A3 like 1 (from RefSeq NM_001142734.1) E9PV04 E9PV04_MOUSE ENSMUST00000204530.1 Eif4a3l1 Gm5576 Gm8994 NM_001142734 uc012euv.1 uc012euv.2 Nucleus speckle Belongs to the DEAD box helicase family. eIF4A subfamily. nucleotide binding nucleic acid binding RNA binding mRNA binding helicase activity ATP binding nucleolus hydrolase activity catalytic step 2 spliceosome uc012euv.1 uc012euv.2 
ENSMUST00000204538.2 Gm44249 ENSMUST00000204538.2 Gm44249 (from geneSymbol) AB346088 ENSMUST00000204538.1 uc291hfa.1 uc291hfa.2 uc291hfa.1 uc291hfa.2 
ENSMUST00000204539.2 Gm44185 ENSMUST00000204539.2 Gm44185 (from geneSymbol) AK040700 ENSMUST00000204539.1 uc291eqp.1 uc291eqp.2 uc291eqp.1 uc291eqp.2 
ENSMUST00000204543.2 Gm44369 ENSMUST00000204543.2 Gm44369 (from geneSymbol) ENSMUST00000204543.1 uc291gpb.1 uc291gpb.2 uc291gpb.1 uc291gpb.2 
ENSMUST00000204545.3 Pals2 ENSMUST00000204545.3 protein associated with LIN7 2, MAGUK family member, transcript variant 14 (from RefSeq NM_001411367.1) Dlgh4 ENSMUST00000204545.1 ENSMUST00000204545.2 Mpp6 NM_001411367 PALS2_MOUSE Pals2 Q9JLB0 Q9JLB1 Q9WV37 uc291eji.1 uc291eji.2 Interacts with CADM1. Interacts with the LIN7 proteins. Q9JLB0; O70318: Epb41l2; NbExp=3; IntAct=EBI-771456, EBI-643339; Membrane; Peripheral membrane protein. Event=Alternative splicing; Named isoforms=2; Name=Beta; IsoId=Q9JLB0-1; Sequence=Displayed; Name=Alpha; IsoId=Q9JLB0-2; Sequence=VSP_003161; Belongs to the MAGUK family. guanylate kinase activity protein binding plasma membrane membrane integral component of membrane GMP metabolic process GDP metabolic process uc291eji.1 uc291eji.2 
ENSMUST00000204549.2 Gm43940 ENSMUST00000204549.2 Gm43940 (from geneSymbol) AK215704 ENSMUST00000204549.1 uc291jxt.1 uc291jxt.2 uc291jxt.1 uc291jxt.2 
ENSMUST00000204556.2 Gm44209 ENSMUST00000204556.2 Gm44209 (from geneSymbol) ENSMUST00000204556.1 uc291gak.1 uc291gak.2 uc291gak.1 uc291gak.2 
ENSMUST00000204559.2 Gm44154 ENSMUST00000204559.2 Gm44154 (from geneSymbol) ENSMUST00000204559.1 uc291idt.1 uc291idt.2 uc291idt.1 uc291idt.2 
ENSMUST00000204561.2 Gm43910 ENSMUST00000204561.2 Gm43910 (from geneSymbol) ENSMUST00000204561.1 uc291kdu.1 uc291kdu.2 uc291kdu.1 uc291kdu.2 
ENSMUST00000204568.2 Gm44207 ENSMUST00000204568.2 Gm44207 (from geneSymbol) AK082065 ENSMUST00000204568.1 uc291gxl.1 uc291gxl.2 uc291gxl.1 uc291gxl.2 
ENSMUST00000204572.2 Gm43984 ENSMUST00000204572.2 Gm43984 (from geneSymbol) ENSMUST00000204572.1 uc291jqf.1 uc291jqf.2 uc291jqf.1 uc291jqf.2 
ENSMUST00000204573.3 Or6c207 ENSMUST00000204573.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFH3) ENSMUST00000204573.1 ENSMUST00000204573.2 Olfr777 Olfr800 Or6c207 Q8VFH3 Q8VFH3_MOUSE uc287vxj.1 uc287vxj.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vxj.1 uc287vxj.2 
ENSMUST00000204587.4 Or7a38 ENSMUST00000204587.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q5G9) A0A0N4SUS1 E9Q5G9 E9Q5G9_MOUSE ENSMUST00000204587.1 ENSMUST00000204587.2 ENSMUST00000204587.3 Olfr1354 Or7a38 uc287sqt.1 uc287sqt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287sqt.1 uc287sqt.2 
ENSMUST00000204588.2 Gm45769 ENSMUST00000204588.2 Gm45769 (from geneSymbol) AK078025 ENSMUST00000204588.1 uc291jpl.1 uc291jpl.2 uc291jpl.1 uc291jpl.2 
ENSMUST00000204604.2 Gm40377 ENSMUST00000204604.2 Gm40377 (from geneSymbol) ENSMUST00000204604.1 uc291fwn.1 uc291fwn.2 uc291fwn.1 uc291fwn.2 
ENSMUST00000204605.2 2010109P13Rik ENSMUST00000204605.2 2010109P13Rik (from geneSymbol) AK008372 ENSMUST00000204605.1 uc291hle.1 uc291hle.2 uc291hle.1 uc291hle.2 
ENSMUST00000204619.2 Gm35549 ENSMUST00000204619.2 Gm35549 (from geneSymbol) A0A0N4SUS7 A0A0N4SUS7_MOUSE ENSMUST00000204619.1 Gm35549 uc292mnc.1 uc292mnc.2 uc292mnc.1 uc292mnc.2 
ENSMUST00000204622.3 Or6c76b ENSMUST00000204622.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRH5) ENSMUST00000204622.1 ENSMUST00000204622.2 Olfr808 Olfr809 Olfr813 Or6c76b Q7TRH5 Q7TRH5_MOUSE uc287vzq.1 uc287vzq.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vzq.1 uc287vzq.2 
ENSMUST00000204623.2 Gm44056 ENSMUST00000204623.2 Gm44056 (from geneSymbol) ENSMUST00000204623.1 uc291jev.1 uc291jev.2 uc291jev.1 uc291jev.2 
ENSMUST00000204630.2 Gm38910 ENSMUST00000204630.2 Gm38910 (from geneSymbol) ENSMUST00000204630.1 uc291jqt.1 uc291jqt.2 uc291jqt.1 uc291jqt.2 
ENSMUST00000204631.2 Gm44095 ENSMUST00000204631.2 Gm44095 (from geneSymbol) AK035487 ENSMUST00000204631.1 uc291hes.1 uc291hes.2 uc291hes.1 uc291hes.2 
ENSMUST00000204633.2 Gm16499 ENSMUST00000204633.2 Gm16499 (from geneSymbol) BC006619 ENSMUST00000204633.1 uc291epa.1 uc291epa.2 uc291epa.1 uc291epa.2 
ENSMUST00000204638.2 Gm31747 ENSMUST00000204638.2 predicted gene, 31747 (from RefSeq NR_157242.1) ENSMUST00000204638.1 NR_157242 uc291fwz.1 uc291fwz.2 uc291fwz.1 uc291fwz.2 
ENSMUST00000204640.2 Gm43937 ENSMUST00000204640.2 Gm43937 (from geneSymbol) AK143254 ENSMUST00000204640.1 uc291guw.1 uc291guw.2 uc291guw.1 uc291guw.2 
ENSMUST00000204641.3 Or6c3b ENSMUST00000204641.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFI3) A0A0N4SW72 ENSMUST00000204641.1 ENSMUST00000204641.2 Olfr803 Or6c3b Q8VFI3 Q8VFI3_MOUSE uc287vyt.1 uc287vyt.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vyt.1 uc287vyt.2 
ENSMUST00000204652.2 Gm44078 ENSMUST00000204652.2 Gm44078 (from geneSymbol) ENSMUST00000204652.1 uc291jia.1 uc291jia.2 uc291jia.1 uc291jia.2 
ENSMUST00000204659.3 Il5ra ENSMUST00000204659.3 interleukin 5 receptor, alpha (from RefSeq NM_008370.2) ENSMUST00000204659.1 ENSMUST00000204659.2 Il5ra NM_008370 Q05A81 Q05A81_MOUSE uc009dcx.1 uc009dcx.2 uc009dcx.3 uc009dcx.4 Membrane ; Single- pass type I membrane protein cytokine receptor activity membrane integral component of membrane cytokine-mediated signaling pathway uc009dcx.1 uc009dcx.2 uc009dcx.3 uc009dcx.4 
ENSMUST00000204662.2 Gm44123 ENSMUST00000204662.2 Gm44123 (from geneSymbol) ENSMUST00000204662.1 uc291hbl.1 uc291hbl.2 uc291hbl.1 uc291hbl.2 
ENSMUST00000204667.2 Gpr162 ENSMUST00000204667.2 G protein-coupled receptor 162, transcript variant 7 (from RefSeq NM_001409843.1) ENSMUST00000204667.1 GP162_MOUSE NM_001409843 O88835 Q3UN16 uc009dsh.1 uc009dsh.2 uc009dsh.3 uc009dsh.4 Orphan receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane uc009dsh.1 uc009dsh.2 uc009dsh.3 uc009dsh.4 
ENSMUST00000204669.2 Gm44090 ENSMUST00000204669.2 Gm44090 (from geneSymbol) AK048984 ENSMUST00000204669.1 uc291gmr.1 uc291gmr.2 uc291gmr.1 uc291gmr.2 
ENSMUST00000204670.3 2610017A05Rik ENSMUST00000204670.3 2610017A05Rik (from geneSymbol) AK160206 ENSMUST00000204670.1 ENSMUST00000204670.2 uc291kkd.1 uc291kkd.2 uc291kkd.3 uc291kkd.1 uc291kkd.2 uc291kkd.3 
ENSMUST00000204674.3 Cpvl ENSMUST00000204674.3 carboxypeptidase, vitellogenic-like, transcript variant 2 (from RefSeq NM_001289713.1) B2RQB1 CPVL_MOUSE ENSMUST00000204674.1 ENSMUST00000204674.2 NM_001289713 Q9D3S9 uc012emd.1 uc012emd.2 uc012emd.3 uc012emd.4 This gene encodes a member of the serine carboxypeptidase family of proteases that cleave amino acids from the C-terminus of a protein substrate. The human ortholog of this gene, where it was first characterized, was found to be upregulated during the maturation of monocytes to macrophages. The encoded protein may be involved in antigen processing, digestion of phagocytosed proteins in the lysosome and lamellipodium formation. Disruption of this gene in mice was found to cause embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]. May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D3S9-1; Sequence=Displayed; Name=2; IsoId=Q9D3S9-2; Sequence=VSP_033260; Belongs to the peptidase S10 family. carboxypeptidase activity serine-type carboxypeptidase activity proteolysis peptidase activity hydrolase activity proteolysis involved in cellular protein catabolic process uc012emd.1 uc012emd.2 uc012emd.3 uc012emd.4 
ENSMUST00000204678.3 Gm6559 ENSMUST00000204678.3 predicted gene 6559 (from RefSeq NR_110455.1) ENSMUST00000204678.1 ENSMUST00000204678.2 NR_110455 uc033irt.1 uc033irt.2 uc033irt.3 uc033irt.1 uc033irt.2 uc033irt.3 
ENSMUST00000204682.3 Prokr1 ENSMUST00000204682.3 prokineticin receptor 1, transcript variant 2 (from RefSeq NM_001355655.1) ENSMUST00000204682.1 ENSMUST00000204682.2 Gpr73 NM_001355655 PKR1_MOUSE Pkr1 Q3U0M4 Q6PD11 Q9JKL1 uc009ctp.1 uc009ctp.2 uc009ctp.3 Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity). Cell membrane; Multi-pass membrane protein. Expressed at high levels in the heart, skeletal muscle and pancreas. Expressed at lower levels in the brain, lung, liver and kidney. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity neuropeptide Y receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway circadian rhythm membrane integral component of membrane cellular response to hormone stimulus negative regulation of apoptotic process coronary vasculature development uc009ctp.1 uc009ctp.2 uc009ctp.3 
ENSMUST00000204686.2 Gm45193 ENSMUST00000204686.2 Gm45193 (from geneSymbol) AK015214 ENSMUST00000204686.1 uc009ccg.1 uc009ccg.2 uc009ccg.3 uc009ccg.1 uc009ccg.2 uc009ccg.3 
ENSMUST00000204687.3 Reg1 ENSMUST00000204687.3 Reg1 (from geneSymbol) AK133506 ENSMUST00000204687.1 ENSMUST00000204687.2 Q3TV26 Q3TV26_MOUSE Reg1 uc291fyo.1 uc291fyo.2 response to hypoxia receptor binding extracellular space cytosol signal transduction midgut development growth factor activity negative regulation of cell proliferation positive regulation of gene expression response to organic cyclic compound phosphatase binding protein phosphatase binding carbohydrate binding growth cone response to nutrient levels dendrite membrane neuronal cell body membrane macromolecular complex wound healing zymogen granule identical protein binding protein homodimerization activity basal part of cell perinuclear region of cytoplasm protein homooligomerization protein homotetramerization calcium ion homeostasis liver regeneration response to acetylsalicylate positive regulation of dendrite extension positive regulation of type B pancreatic cell proliferation positive regulation of acinar cell proliferation response to water-immersion restraint stress pancreas regeneration response to growth hormone-releasing hormone response to gastrin cellular response to chemokine cellular response to gastrin uc291fyo.1 uc291fyo.2 
ENSMUST00000204689.2 Gm44296 ENSMUST00000204689.2 Gm44296 (from geneSymbol) ENSMUST00000204689.1 uc291dfz.1 uc291dfz.2 uc291dfz.1 uc291dfz.2 
ENSMUST00000204702.3 Hspa4l ENSMUST00000204702.3 heat shock protein 4 like, transcript variant 1 (from RefSeq NM_011020.4) Apg1 ENSMUST00000204702.1 ENSMUST00000204702.2 HS74L_MOUSE Hsp4l NM_011020 Osp94 P48722 P97854 Q3TQN2 Q3UNG4 Q8BQD0 Q8CC45 Q91X29 uc008pbk.1 uc008pbk.2 uc008pbk.3 Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. Homodimer. P48722; Q99P72: Rtn4; NbExp=4; IntAct=EBI-8314699, EBI-3869532; P48722; Q9JK11-1: Rtn4; Xeno; NbExp=6; IntAct=EBI-8314699, EBI-919989; Cytoplasm Nucleus Note=May translocate to the nucleus after heat shock. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48722-1; Sequence=Displayed; Name=2; Synonyms=Apg-1b; IsoId=P48722-2; Sequence=VSP_007500; Highly expressed in testis. Also expressed in renal medulla of water-restricted animals. By hyperosmolar salt stress and heat shock. Belongs to the heat shock protein 70 family. nucleotide binding protein binding ATP binding nucleus cytoplasm cytosol protein folding response to unfolded protein uc008pbk.1 uc008pbk.2 uc008pbk.3 
ENSMUST00000204703.2 Gm44094 ENSMUST00000204703.2 Gm44094 (from geneSymbol) ENSMUST00000204703.1 uc291ckv.1 uc291ckv.2 uc291ckv.1 uc291ckv.2 
ENSMUST00000204704.2 Gm44151 ENSMUST00000204704.2 Gm44151 (from geneSymbol) ENSMUST00000204704.1 uc291kny.1 uc291kny.2 uc291kny.1 uc291kny.2 
ENSMUST00000204706.3 Or2y13 ENSMUST00000204706.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQT2) ENSMUST00000204706.1 ENSMUST00000204706.2 Olfr1383 Or2y13 Q7TQT2 Q7TQT2_MOUSE uc007iqq.1 uc007iqq.2 uc007iqq.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007iqq.1 uc007iqq.2 uc007iqq.3 
ENSMUST00000204720.2 Gm44157 ENSMUST00000204720.2 Gm44157 (from geneSymbol) ENSMUST00000204720.1 uc291hzf.1 uc291hzf.2 uc291hzf.1 uc291hzf.2 
ENSMUST00000204722.2 Gm44204 ENSMUST00000204722.2 Gm44204 (from geneSymbol) AK155541 ENSMUST00000204722.1 uc291gxc.1 uc291gxc.2 uc291gxc.1 uc291gxc.2 
ENSMUST00000204727.2 Gm43887 ENSMUST00000204727.2 Gm43887 (from geneSymbol) ENSMUST00000204727.1 uc291ebu.1 uc291ebu.2 uc291ebu.1 uc291ebu.2 
ENSMUST00000204735.2 Gm44187 ENSMUST00000204735.2 Gm44187 (from geneSymbol) AK050786 ENSMUST00000204735.1 uc291gte.1 uc291gte.2 uc291gte.1 uc291gte.2 
ENSMUST00000204736.2 Gm44104 ENSMUST00000204736.2 Gm44104 (from geneSymbol) ENSMUST00000204736.1 uc291hku.1 uc291hku.2 uc291hku.1 uc291hku.2 
ENSMUST00000204738.3 1600020E01Rik ENSMUST00000204738.3 1600020E01Rik (from geneSymbol) AK036497 ENSMUST00000204738.1 ENSMUST00000204738.2 uc291gox.1 uc291gox.2 uc291gox.1 uc291gox.2 
ENSMUST00000204742.2 Gm43869 ENSMUST00000204742.2 Gm43869 (from geneSymbol) AK149130 ENSMUST00000204742.1 uc291ebi.1 uc291ebi.2 uc291ebi.1 uc291ebi.2 
ENSMUST00000204751.3 Zfp638 ENSMUST00000204751.3 zinc finger protein 638, transcript variant 1 (from RefSeq NM_008717.4) A0A0N4SV80 A0A0N4SV80_MOUSE ENSMUST00000204751.1 ENSMUST00000204751.2 NM_008717 Zfp638 uc009con.1 uc009con.2 uc009con.3 uc009con.4 nucleic acid binding RNA binding nucleus nucleoplasm zinc ion binding RNA splicing intracellular membrane-bounded organelle metal ion binding uc009con.1 uc009con.2 uc009con.3 uc009con.4 
ENSMUST00000204763.3 Or6c200-ps1 ENSMUST00000204763.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BQ22) A0A2I3BQ22 A0A2I3BQ22_MOUSE ENSMUST00000204763.1 ENSMUST00000204763.2 Or6c200-ps1 uc287vws.1 uc287vws.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vws.1 uc287vws.2 
ENSMUST00000204767.2 Gm43950 ENSMUST00000204767.2 Gm43950 (from geneSymbol) ENSMUST00000204767.1 uc291hma.1 uc291hma.2 uc291hma.1 uc291hma.2 
ENSMUST00000204769.2 Gm35808 ENSMUST00000204769.2 Gm35808 (from geneSymbol) ENSMUST00000204769.1 uc289vtg.1 uc289vtg.2 uc289vtg.1 uc289vtg.2 
ENSMUST00000204773.2 Zfp813-ps ENSMUST00000204773.2 Zfp813-ps (from geneSymbol) ENSMUST00000204773.1 uc287lar.1 uc287lar.2 uc287lar.1 uc287lar.2 
ENSMUST00000204774.3 Il17re ENSMUST00000204774.3 interleukin 17 receptor E, transcript variant 5 (from RefSeq NM_001362205.1) ENSMUST00000204774.1 ENSMUST00000204774.2 I17RE_MOUSE NM_001362205 Q3I5F0 Q6NSU9 Q8BH06 Q8C5D0 Q8K4C1 Q8R335 uc291hva.1 uc291hva.2 Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors. Forms heterodimers with IL17RA; the heterodimer binds IL17C. [Isoform 1]: Cell membrane; Single-pass type I membrane protein. [Isoform 2]: Secreted [Isoform 3]: Secreted [Isoform 4]: Cytoplasm [Isoform 5]: Cytoplasm Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=IL-17RE1, IL17RE-S; IsoId=Q8BH06-1; Sequence=Displayed; Name=2; Synonyms=IL-17RE2; IsoId=Q8BH06-2; Sequence=VSP_029200; Name=3; Synonyms=IL-17RE3; IsoId=Q8BH06-3; Sequence=VSP_029199; Name=4; Synonyms=IL-17RE4, IL-17RE5, IL17RE-S; IsoId=Q8BH06-4; Sequence=VSP_029198; Name=5; Synonyms=IL-17RE6; IsoId=Q8BH06-5; Sequence=VSP_029197; Predominantly expressed in mucosal tissues, including trachea, lung, kidney and stomach. Highly expressed in colon epithelial cells. Also expressed in testis. Low expression, if any, in heart, liver, spleen, or brain. Among CD4 T-helper cells, expressed at high levels in Th17 cells. Expression starts at 10.5 dpc and reaches a plateau of expression at 12.5 dpc. Up-regulated by its own ligand IL17C. Also up-regulated by IL6 and TNF acting synergically. This induction can be further increased by IL23. Mutant animals are born normally at the expected Mendelian frequency. They exhibit much lower expression of genes encoding antibacterial molecules, much greater bacterial burdens and total mortality after infection with Citrobacter rodentium. Sequence=BAC37436.1; Type=Frameshift; Evidence=; extracellular region cytoplasm plasma membrane inflammatory response membrane integral component of membrane cytokine-mediated signaling pathway interleukin-17 receptor activity uc291hva.1 uc291hva.2 
ENSMUST00000204778.3 Skap2 ENSMUST00000204778.3 src family associated phosphoprotein 2 (from RefSeq NM_018773.2) ENSMUST00000204778.1 ENSMUST00000204778.2 NM_018773 Prap Q3UND0 Q8BK74 Q9Z2K4 Ra70 SKAP2_MOUSE Saps Scap2 Skap55r uc009bxv.1 uc009bxv.2 uc009bxv.3 May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. Interacts with LAT, GRB2, PTK2B and PRAM1 (By similarity). Homodimer. Interacts with FYB1, which is required for SKAP2 protein stability. Interacts with PTPNS1. Part of a complex consisting of SKAP2, FYB1 and PTPNS1. Part of a complex consisting of SKAP2, FYB1 and LILRB3. May interact with actin. May interact with FYN, HCK and LYN. Interacts with FASLG (By similarity). Q3UND0; Q9Y2R2: PTPN22; Xeno; NbExp=2; IntAct=EBI-642769, EBI-1211241; Cytoplasm Note=Membrane ruffles of macrophages. Perikarya and dendrites from neurons. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UND0-1; Sequence=Displayed; Name=2; IsoId=Q3UND0-2; Sequence=VSP_022184; Expressed in kidney, lung, liver, spleen, bone marrow and testis. Present in T-cells, B-cells, and all cells of the myelomonocytic lineage. Present in all brain regions, with highest levels in neurons from the Purkinje cell layer, hippocampal gyrus, cortex and substantia nigra (at protein level). By IL-6 in myeloid cells. The SH3 domain interacts with FYB1 and PTK2B. Dephosphorylated on Tyr-75 by PTPN22 (By similarity). Phosphorylated by FYN on Tyr-260. In case of infection with Y.pseudotuberculosis, dephosphorylated by bacterial phosphatase yopH. Mice are healthy and do not display any obvious abnormality. They have normal T-cell, platelet and macrophage function, but show reduced levels of spontaneous immunoglobulins in the serum, and defects in B-cell proliferation. Belongs to the SKAP family. protein binding nucleoplasm cytoplasm cytosol plasma membrane negative regulation of cell proliferation B cell activation uc009bxv.1 uc009bxv.2 uc009bxv.3 
ENSMUST00000204799.3 4930504D19Rik ENSMUST00000204799.3 4930504D19Rik (from geneSymbol) AK019668 ENSMUST00000204799.1 ENSMUST00000204799.2 uc291gjd.1 uc291gjd.2 uc291gjd.3 uc291gjd.1 uc291gjd.2 uc291gjd.3 
ENSMUST00000204808.2 Gm20362 ENSMUST00000204808.2 predicted gene, 20362, transcript variant 2 (from RefSeq NR_040302.1) ENSMUST00000204808.1 NR_040302 uc009ckd.1 uc009ckd.2 uc009ckd.3 uc009ckd.1 uc009ckd.2 uc009ckd.3 
ENSMUST00000204812.2 Gm3455 ENSMUST00000204812.2 Gm3455 (from geneSymbol) AK032368 ENSMUST00000204812.1 uc291ejh.1 uc291ejh.2 uc291ejh.1 uc291ejh.2 
ENSMUST00000204814.2 Gm44268 ENSMUST00000204814.2 Gm44268 (from geneSymbol) AK180294 ENSMUST00000204814.1 uc291jxf.1 uc291jxf.2 uc291jxf.1 uc291jxf.2 
ENSMUST00000204816.2 Gm44037 ENSMUST00000204816.2 Gm44037 (from geneSymbol) ENSMUST00000204816.1 uc290oeq.1 uc290oeq.2 uc290oeq.1 uc290oeq.2 
ENSMUST00000204817.2 Gm43931 ENSMUST00000204817.2 Gm43931 (from geneSymbol) ENSMUST00000204817.1 uc291kfj.1 uc291kfj.2 uc291kfj.1 uc291kfj.2 
ENSMUST00000204820.3 Or6c88 ENSMUST00000204820.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF26) ENSMUST00000204820.1 ENSMUST00000204820.2 Olfr794 Or6c88 Q8VF26 Q8VF26_MOUSE uc287vyd.1 uc287vyd.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vyd.1 uc287vyd.2 
ENSMUST00000204822.2 Gm44193 ENSMUST00000204822.2 Gm44193 (from geneSymbol) ENSMUST00000204822.1 uc291hqy.1 uc291hqy.2 uc291hqy.1 uc291hqy.2 
ENSMUST00000204830.2 Ube2q2l ENSMUST00000204830.2 ubiquitin conjugating enzyme E2 Q2 like (from RefSeq NM_001201390.1) E330021D16Rik ENSMUST00000204830.1 NM_001201390 Q8BW45 Q8BW45_MOUSE Ube2q2l uc009elt.1 uc009elt.2 uc009elt.3 uc009elt.4 uc009elt.5 cellular_component ubiquitin conjugating enzyme activity protein K48-linked ubiquitination uc009elt.1 uc009elt.2 uc009elt.3 uc009elt.4 uc009elt.5 
ENSMUST00000204833.2 Gm43969 ENSMUST00000204833.2 Gm43969 (from geneSymbol) ENSMUST00000204833.1 uc291juh.1 uc291juh.2 uc291juh.1 uc291juh.2 
ENSMUST00000204835.2 Gm44168 ENSMUST00000204835.2 Gm44168 (from geneSymbol) ENSMUST00000204835.1 uc291gta.1 uc291gta.2 uc291gta.1 uc291gta.2 
ENSMUST00000204851.2 Gm43924 ENSMUST00000204851.2 Gm43924 (from geneSymbol) ENSMUST00000204851.1 uc291cqk.1 uc291cqk.2 uc291cqk.1 uc291cqk.2 
ENSMUST00000204853.2 Gm43874 ENSMUST00000204853.2 Gm43874 (from geneSymbol) AK036001 ENSMUST00000204853.1 uc291ebh.1 uc291ebh.2 uc291ebh.1 uc291ebh.2 
ENSMUST00000204863.3 Gm44175 ENSMUST00000204863.3 Gm44175 (from geneSymbol) AK042210 ENSMUST00000204863.1 ENSMUST00000204863.2 uc009cgq.1 uc009cgq.2 uc009cgq.3 uc009cgq.4 uc009cgq.1 uc009cgq.2 uc009cgq.3 uc009cgq.4 
ENSMUST00000204868.2 Gm43900 ENSMUST00000204868.2 Gm43900 (from geneSymbol) AK038675 ENSMUST00000204868.1 uc291fzm.1 uc291fzm.2 uc291fzm.1 uc291fzm.2 
ENSMUST00000204871.2 Gm43882 ENSMUST00000204871.2 Gm43882 (from geneSymbol) ENSMUST00000204871.1 uc291ebk.1 uc291ebk.2 uc291ebk.1 uc291ebk.2 
ENSMUST00000204883.2 Gm44200 ENSMUST00000204883.2 Gm44200 (from geneSymbol) ENSMUST00000204883.1 uc291hvv.1 uc291hvv.2 uc291hvv.1 uc291hvv.2 
ENSMUST00000204888.2 Gm44228 ENSMUST00000204888.2 Gm44228 (from geneSymbol) ENSMUST00000204888.1 uc291fzf.1 uc291fzf.2 uc291fzf.1 uc291fzf.2 
ENSMUST00000204889.2 Gm44079 ENSMUST00000204889.2 Gm44079 (from geneSymbol) ENSMUST00000204889.1 uc291hyx.1 uc291hyx.2 uc291hyx.1 uc291hyx.2 
ENSMUST00000204890.3 Cnbp ENSMUST00000204890.3 cellular nucleic acid binding protein, transcript variant 5 (from RefSeq NM_001355195.1) A0A0N4SVS6 A0A0N4SVS6_MOUSE Cnbp ENSMUST00000204890.1 ENSMUST00000204890.2 NM_001355195 uc009cue.1 uc009cue.2 uc009cue.3 uc009cue.4 nucleic acid binding zinc ion binding uc009cue.1 uc009cue.2 uc009cue.3 uc009cue.4 
ENSMUST00000204898.2 Gm44069 ENSMUST00000204898.2 Gm44069 (from geneSymbol) ENSMUST00000204898.1 uc291jut.1 uc291jut.2 uc291jut.1 uc291jut.2 
ENSMUST00000204899.2 Gm43980 ENSMUST00000204899.2 Gm43980 (from geneSymbol) ENSMUST00000204899.1 LF195486 uc291eit.1 uc291eit.2 uc291eit.1 uc291eit.2 
ENSMUST00000204905.2 Gm44049 ENSMUST00000204905.2 Gm44049 (from geneSymbol) ENSMUST00000204905.1 uc291esz.1 uc291esz.2 uc291esz.1 uc291esz.2 
ENSMUST00000204906.2 Gm44045 ENSMUST00000204906.2 Gm44045 (from geneSymbol) AK141746 ENSMUST00000204906.1 uc291hlj.1 uc291hlj.2 uc291hlj.1 uc291hlj.2 
ENSMUST00000204910.2 Gm44215 ENSMUST00000204910.2 Gm44215 (from geneSymbol) ENSMUST00000204910.1 LF300522 uc291jhp.1 uc291jhp.2 uc291jhp.1 uc291jhp.2 
ENSMUST00000204911.3 4930417O13Rik ENSMUST00000204911.3 4930417O13Rik (from geneSymbol) AK030803 ENSMUST00000204911.1 ENSMUST00000204911.2 uc009dug.1 uc009dug.2 uc009dug.1 uc009dug.2 
ENSMUST00000204922.2 Gm44472 ENSMUST00000204922.2 Gm44472 (from geneSymbol) ENSMUST00000204922.1 uc291cok.1 uc291cok.2 uc291cok.1 uc291cok.2 
ENSMUST00000204925.2 Gm44258 ENSMUST00000204925.2 Gm44258 (from geneSymbol) AK039690 ENSMUST00000204925.1 uc291jvh.1 uc291jvh.2 uc291jvh.1 uc291jvh.2 
ENSMUST00000204927.2 D6Ertd527e ENSMUST00000204927.2 DNA segment, Chr 6, ERATO Doi 527, expressed, transcript variant 2 (from RefSeq NR_176827.1) ENSMUST00000204927.1 NR_176827 uc009ctc.1 uc009ctc.2 uc009ctc.3 uc009ctc.4 uc009ctc.1 uc009ctc.2 uc009ctc.3 uc009ctc.4 
ENSMUST00000204928.2 Gm43885 ENSMUST00000204928.2 Gm43885 (from geneSymbol) ENSMUST00000204928.1 uc291ebf.1 uc291ebf.2 uc291ebf.1 uc291ebf.2 
ENSMUST00000204930.3 Rarres2 ENSMUST00000204930.3 retinoic acid receptor responder (tazarotene induced) 2, transcript variant 3 (from RefSeq NM_001347168.1) ENSMUST00000204930.1 ENSMUST00000204930.2 NM_001347168 Q8CHU8 Q9DD06 RARR2_MOUSE uc291efr.1 uc291efr.2 Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Acts also as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2. Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Exhibits an antimicrobial function in the skin. Secreted Expressed in the differentiated adipocytes (at protein level). Abundantly expressed in the liver, adipose tissue including visceral, epididymal, and brown adipose tissue. Strongly induced during adipocyte differentiation. Secreted in an inactive precursor form, prochemerin, which is proteolytically processed by a variety of extracellular proteases to generate forms with differing levels of bioactivity. For example, the removal of six amino acids results in chemerin-156, which exhibits the highest activity, while removal of seven amino acids results in chemerin-155 which has slightly less activity. Some proteases are able to cleave at more than one site and chemerin forms may be sequentially processed by different enzymes to modulate activity levels. The coordinated expression and activity of chemerin-modifying enzymes is essential for regulating its bioactivation, inactivation and, consequently, biological function. Cathepsin G cleaves seven C-terminal amino acids from prochemerin (chemerin-155), elastase is able to cleave six (chemerin-156), eight (chemerin-154) or eleven (chemerin-151), plasmin cleaves five amino acids (chemerin-157), and tryptase cleaves five (chemerin-157) or eight (chemerin-154). Multiple cleavages might be required to fully activate chemerin, with an initial tryptase cleavage resulting in chemerin with low activity (chemerin-157), and a second cleavage by carboxypeptidase N or B producing highly active chemerin (chemerin-156) (By similarity). retinoid metabolic process positive regulation of protein phosphorylation receptor binding protein binding extracellular region extracellular space chemotaxis inflammatory response insulin receptor signaling pathway positive regulation of macrophage chemotaxis antifungal humoral response cell differentiation innate immune response positive regulation of fat cell differentiation regulation of insulin receptor signaling pathway embryonic digestive tract development defense response to Gram-negative bacterium defense response to Gram-positive bacterium brown fat cell differentiation positive regulation of chemotaxis regulation of lipid catabolic process antifungal innate immune response uc291efr.1 uc291efr.2 
ENSMUST00000204931.2 Gm43871 ENSMUST00000204931.2 Gm43871 (from geneSymbol) AK047803 ENSMUST00000204931.1 uc291ebq.1 uc291ebq.2 uc291ebq.1 uc291ebq.2 
ENSMUST00000204933.2 Gm44366 ENSMUST00000204933.2 Gm44366 (from geneSymbol) ENSMUST00000204933.1 uc291jrq.1 uc291jrq.2 uc291jrq.1 uc291jrq.2 
ENSMUST00000204945.3 Gm43904 ENSMUST00000204945.3 Gm43904 (from geneSymbol) ENSMUST00000204945.1 ENSMUST00000204945.2 uc291gro.1 uc291gro.2 uc291gro.3 uc291gro.1 uc291gro.2 uc291gro.3 
ENSMUST00000204946.2 Gm44260 ENSMUST00000204946.2 Gm44260 (from geneSymbol) ENSMUST00000204946.1 LF195840 uc291ilj.1 uc291ilj.2 uc291ilj.1 uc291ilj.2 
ENSMUST00000204953.2 Gm43920 ENSMUST00000204953.2 Gm43920 (from geneSymbol) AK050975 ENSMUST00000204953.1 uc291gii.1 uc291gii.2 uc291gii.1 uc291gii.2 
ENSMUST00000204957.2 Gm44167 ENSMUST00000204957.2 Gm44167 (from geneSymbol) ENSMUST00000204957.1 uc291hwu.1 uc291hwu.2 uc291hwu.1 uc291hwu.2 
ENSMUST00000204964.3 Gm44064 ENSMUST00000204964.3 Gm44064 (from geneSymbol) ENSMUST00000204964.1 ENSMUST00000204964.2 uc291gsi.1 uc291gsi.2 uc291gsi.3 uc291gsi.1 uc291gsi.2 uc291gsi.3 
ENSMUST00000204973.2 Gm3793 ENSMUST00000204973.2 Gm3793 (from geneSymbol) AK040267 ENSMUST00000204973.1 uc291esx.1 uc291esx.2 uc291esx.1 uc291esx.2 
ENSMUST00000204978.3 Ndufa4 ENSMUST00000204978.3 Ndufa4, mitochondrial complex associated (from RefSeq NM_010886.3) ENSMUST00000204978.1 ENSMUST00000204978.2 NDUA4_MOUSE NM_010886 Q62425 Q9CQP6 uc009ayd.1 uc009ayd.2 uc009ayd.3 Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. NDUFA4 is required for complex IV maintenance. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding. Mitochondrion inner membrane ; Single-pass membrane protein Belongs to the complex IV NDUFA4 subunit family. cytochrome-c oxidase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex IV membrane electron transport chain macromolecular complex binding oxidation-reduction process respiratory chain hydrogen ion transmembrane transport mitochondrial respiratory chain complex I uc009ayd.1 uc009ayd.2 uc009ayd.3 
ENSMUST00000204979.3 Or6c66 ENSMUST00000204979.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRH8) ENSMUST00000204979.1 ENSMUST00000204979.2 Olfr798 Or6c66 Q7TRH8 Q7TRH8_MOUSE uc287vyi.1 uc287vyi.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vyi.1 uc287vyi.2 
ENSMUST00000204981.2 Clec2f ENSMUST00000204981.2 C-type lectin domain family 2, member f (from RefSeq NM_001277202.1) Clec2f Clrz ENSMUST00000204981.1 F5CSM8 F5CSM8_MOUSE NM_001277202 uc029wbn.1 uc029wbn.2 uc029wbn.3 Cell membrane ; Single-pass type II membrane protein membrane integral component of membrane carbohydrate binding uc029wbn.1 uc029wbn.2 uc029wbn.3 
ENSMUST00000204992.2 Gm57775 ENSMUST00000204992.2 Gm57775 (from geneSymbol) ENSMUST00000204992.1 uc291jmy.1 uc291jmy.2 uc291jmy.1 uc291jmy.2 
ENSMUST00000204995.2 Gm43982 ENSMUST00000204995.2 Gm43982 (from geneSymbol) ENSMUST00000204995.1 uc291jqe.1 uc291jqe.2 uc291jqe.1 uc291jqe.2 
ENSMUST00000205001.2 Gm10388 ENSMUST00000205001.2 Gm10388 (from geneSymbol) ENSMUST00000205001.1 LF273798 uc291kmc.1 uc291kmc.2 uc291kmc.1 uc291kmc.2 
ENSMUST00000205002.3 Ndufa9 ENSMUST00000205002.3 NADH:ubiquinone oxidoreductase subunit A9 (from RefSeq NM_025358.3) ENSMUST00000205002.1 ENSMUST00000205002.2 NDUA9_MOUSE NM_025358 Q6GTD3 Q99JP9 Q9DC69 uc009dve.1 uc009dve.2 uc009dve.3 uc009dve.4 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit. ; Complex I is composed of 45 different subunits (By similarity). This a component of the hydrophobic protein fraction (By similarity). Interacts with BLOC1S1 (By similarity). Interacts with SLC2A4 (By similarity). Interacts with CLOCK (By similarity). Interacts with RAB5IF (PubMed:31536960). Mitochondrion matrix Acetylated on lysine residues. BLOC1S1 is required for acetylation. Acetylated by CLOCK in a circadian manner. Belongs to the complex I NDUFA9 subunit family. NADH dehydrogenase activity nucleoplasm mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial matrix circadian rhythm response to glucose mitochondrial membrane mitochondrial respiratory chain complex I assembly macromolecular complex binding oxidation-reduction process respiratory chain ubiquinone-6 biosynthetic process uc009dve.1 uc009dve.2 uc009dve.3 uc009dve.4 
ENSMUST00000205007.2 Gm44152 ENSMUST00000205007.2 Gm44152 (from geneSymbol) AK035337 ENSMUST00000205007.1 uc291gpw.1 uc291gpw.2 uc291gpw.1 uc291gpw.2 
ENSMUST00000205011.2 1700040L08Rik ENSMUST00000205011.2 1700040L08Rik (from geneSymbol) AK006662 ENSMUST00000205011.1 uc291fqs.1 uc291fqs.2 uc291fqs.1 uc291fqs.2 
ENSMUST00000205013.3 Or6c216 ENSMUST00000205013.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG64) ENSMUST00000205013.1 ENSMUST00000205013.2 Olfr812 Olfr815 Or6c216 Q8VG64 Q8VG64_MOUSE uc007hqt.1 uc007hqt.2 uc007hqt.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hqt.1 uc007hqt.2 uc007hqt.3 
ENSMUST00000205022.2 Gm44174 ENSMUST00000205022.2 Gm44174 (from geneSymbol) ENSMUST00000205022.1 uc291fqh.1 uc291fqh.2 uc291fqh.1 uc291fqh.2 
ENSMUST00000205029.2 Gm43877 ENSMUST00000205029.2 Gm43877 (from geneSymbol) ENSMUST00000205029.1 uc291ebs.1 uc291ebs.2 uc291ebs.1 uc291ebs.2 
ENSMUST00000205038.3 Gm44000 ENSMUST00000205038.3 Gm44000 (from geneSymbol) AK041447 ENSMUST00000205038.1 ENSMUST00000205038.2 uc291jir.1 uc291jir.2 uc291jir.3 uc291jir.1 uc291jir.2 uc291jir.3 
ENSMUST00000205039.2 Gm43886 ENSMUST00000205039.2 Gm43886 (from geneSymbol) ENSMUST00000205039.1 uc291ebo.1 uc291ebo.2 uc291ebo.1 uc291ebo.2 
ENSMUST00000205047.4 Gm7932 ENSMUST00000205047.4 Gm7932 (from geneSymbol) AK139445 ENSMUST00000205047.1 ENSMUST00000205047.2 ENSMUST00000205047.3 uc009bvz.1 uc009bvz.2 uc009bvz.3 uc009bvz.4 uc009bvz.5 uc009bvz.6 uc009bvz.7 uc009bvz.1 uc009bvz.2 uc009bvz.3 uc009bvz.4 uc009bvz.5 uc009bvz.6 uc009bvz.7 
ENSMUST00000205056.2 Gm44085 ENSMUST00000205056.2 Gm44085 (from geneSymbol) ENSMUST00000205056.1 uc291khm.1 uc291khm.2 uc291khm.1 uc291khm.2 
ENSMUST00000205061.2 Gm44288 ENSMUST00000205061.2 Gm44288 (from geneSymbol) AK047933 ENSMUST00000205061.1 uc291fyd.1 uc291fyd.2 uc291fyd.1 uc291fyd.2 
ENSMUST00000205062.2 Gm43916 ENSMUST00000205062.2 Gm43916 (from geneSymbol) BC065416 ENSMUST00000205062.1 uc291ilq.1 uc291ilq.2 uc291ilq.1 uc291ilq.2 
ENSMUST00000205064.2 Gm44421 ENSMUST00000205064.2 Gm44421 (from geneSymbol) ENSMUST00000205064.1 uc291haz.1 uc291haz.2 uc291haz.1 uc291haz.2 
ENSMUST00000205074.2 Gm43908 ENSMUST00000205074.2 Gm43908 (from geneSymbol) ENSMUST00000205074.1 uc291kko.1 uc291kko.2 uc291kko.1 uc291kko.2 
ENSMUST00000205080.2 Gm43974 ENSMUST00000205080.2 Gm43974 (from geneSymbol) ENSMUST00000205080.1 uc291jnx.1 uc291jnx.2 uc291jnx.1 uc291jnx.2 
ENSMUST00000205083.2 Gm44190 ENSMUST00000205083.2 Gm44190 (from geneSymbol) ENSMUST00000205083.1 uc291jfm.1 uc291jfm.2 uc291jfm.1 uc291jfm.2 
ENSMUST00000205090.2 Gm44294 ENSMUST00000205090.2 Gm44294 (from geneSymbol) BC134399 ENSMUST00000205090.1 uc291enm.1 uc291enm.2 uc291enm.1 uc291enm.2 
ENSMUST00000205099.2 4930595O18Rik ENSMUST00000205099.2 4930595O18Rik (from geneSymbol) AK016395 ENSMUST00000205099.1 uc291hly.1 uc291hly.2 uc291hly.1 uc291hly.2 
ENSMUST00000205100.3 Or7c70 ENSMUST00000205100.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQU8) ENSMUST00000205100.1 ENSMUST00000205100.2 Olfr1356 Or7c70 Q7TQU8 Q7TQU8_MOUSE uc287sqs.1 uc287sqs.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287sqs.1 uc287sqs.2 
ENSMUST00000205102.2 Gm43870 ENSMUST00000205102.2 Gm43870 (from geneSymbol) ENSMUST00000205102.1 uc291ebv.1 uc291ebv.2 uc291ebv.1 uc291ebv.2 
ENSMUST00000205104.2 Gm44448 ENSMUST00000205104.2 Gm44448 (from geneSymbol) ENSMUST00000205104.1 uc291jqn.1 uc291jqn.2 uc291jqn.1 uc291jqn.2 
ENSMUST00000205107.2 D530018E20Rik ENSMUST00000205107.2 D530018E20Rik (from geneSymbol) ENSMUST00000205107.1 uc291fwf.1 uc291fwf.2 uc291fwf.1 uc291fwf.2 
ENSMUST00000205113.3 Gm19757 ENSMUST00000205113.3 predicted gene, 19757 (from RefSeq NR_040297.1) ENSMUST00000205113.1 ENSMUST00000205113.2 NR_040297 uc009dcp.1 uc009dcp.2 uc009dcp.3 uc009dcp.4 uc009dcp.1 uc009dcp.2 uc009dcp.3 uc009dcp.4 
ENSMUST00000205115.2 A930014E10Rik ENSMUST00000205115.2 A930014E10Rik (from geneSymbol) AK020857 ENSMUST00000205115.1 uc291kbq.1 uc291kbq.2 uc291kbq.1 uc291kbq.2 
ENSMUST00000205126.2 Gm43903 ENSMUST00000205126.2 Gm43903 (from geneSymbol) ENSMUST00000205126.1 uc291gxn.1 uc291gxn.2 uc291gxn.1 uc291gxn.2 
ENSMUST00000205127.2 Or13m2-ps1 ENSMUST00000205127.2 Or13m2-ps1 (from geneSymbol) ENSMUST00000205127.1 uc291dza.1 uc291dza.2 uc291dza.1 uc291dza.2 
ENSMUST00000205132.2 Gm43891 ENSMUST00000205132.2 Gm43891 (from geneSymbol) ENSMUST00000205132.1 uc291ham.1 uc291ham.2 uc291ham.1 uc291ham.2 
ENSMUST00000205134.2 Gm44002 ENSMUST00000205134.2 Gm44002 (from geneSymbol) AK185364 ENSMUST00000205134.1 uc291hcm.1 uc291hcm.2 uc291hcm.1 uc291hcm.2 
ENSMUST00000205137.3 Gm44957 ENSMUST00000205137.3 Gm44957 (from geneSymbol) ENSMUST00000205137.1 ENSMUST00000205137.2 uc291icm.1 uc291icm.2 uc291icm.3 uc291icm.1 uc291icm.2 uc291icm.3 
ENSMUST00000205146.2 Gm32592 ENSMUST00000205146.2 Gm32592 (from geneSymbol) AK160945 ENSMUST00000205146.1 uc291hjj.1 uc291hjj.2 uc291hjj.1 uc291hjj.2 
ENSMUST00000205150.2 Gm44014 ENSMUST00000205150.2 Gm44014 (from geneSymbol) AK149894 ENSMUST00000205150.1 uc291iml.1 uc291iml.2 uc291iml.1 uc291iml.2 
ENSMUST00000205153.3 A530053G22Rik ENSMUST00000205153.3 A530053G22Rik (from geneSymbol) AK080087 ENSMUST00000205153.1 ENSMUST00000205153.2 uc012emt.1 uc012emt.2 uc012emt.3 uc012emt.1 uc012emt.2 uc012emt.3 
ENSMUST00000205156.3 Emp1 ENSMUST00000205156.3 Membrane ulti-pass membrane protein (from UniProt Q4FK43) BC046299 ENSMUST00000205156.1 ENSMUST00000205156.2 Emp1 Q4FK43 Q4FK43_MOUSE uc291jsw.1 uc291jsw.2 Membrane ulti-pass membrane protein Belongs to the PMP-22/EMP/MP20 family. Lacks conserved residue(s) required for the propagation of feature annotation. plasma membrane cell death membrane integral component of membrane bleb assembly uc291jsw.1 uc291jsw.2 
ENSMUST00000205157.2 Gm44130 ENSMUST00000205157.2 Gm44130 (from geneSymbol) ENSMUST00000205157.1 uc291fqm.1 uc291fqm.2 uc291fqm.1 uc291fqm.2 
ENSMUST00000205169.2 Gm44121 ENSMUST00000205169.2 Gm44121 (from geneSymbol) ENSMUST00000205169.1 uc291cir.1 uc291cir.2 uc291cir.1 uc291cir.2 
ENSMUST00000205175.3 Or2a52 ENSMUST00000205175.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEV1) ENSMUST00000205175.1 ENSMUST00000205175.2 Olfr437 Or2a52 Q8VEV1 Q8VEV1_MOUSE uc009bsh.1 uc009bsh.2 uc009bsh.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009bsh.1 uc009bsh.2 uc009bsh.3 
ENSMUST00000205178.2 Gm44044 ENSMUST00000205178.2 Gm44044 (from geneSymbol) ENSMUST00000205178.1 LF273953 uc291hlk.1 uc291hlk.2 uc291hlk.1 uc291hlk.2 
ENSMUST00000205183.2 Gm44237 ENSMUST00000205183.2 Gm44237 (from geneSymbol) ENSMUST00000205183.1 uc291icx.1 uc291icx.2 uc291icx.1 uc291icx.2 
ENSMUST00000205187.2 Gm43868 ENSMUST00000205187.2 predicted gene, 43868 (from RefSeq NR_164179.1) ENSMUST00000205187.1 NR_164179 uc291hrs.1 uc291hrs.2 uc291hrs.1 uc291hrs.2 
ENSMUST00000205189.4 Or2t44 ENSMUST00000205189.4 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRZ7) A0A0N4SW61 ENSMUST00000205189.1 ENSMUST00000205189.2 ENSMUST00000205189.3 Olfr314 Or2t44 Q7TRZ7 Q7TRZ7_MOUSE uc287yld.1 uc287yld.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287yld.1 uc287yld.2 
ENSMUST00000205193.3 Or7a37 ENSMUST00000205193.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGU8) A0A0N4SVE8 ENSMUST00000205193.1 ENSMUST00000205193.2 Olfr1353 Or7a37 Q8VGU8 Q8VGU8_MOUSE uc033fqt.1 uc033fqt.2 uc033fqt.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033fqt.1 uc033fqt.2 uc033fqt.3 
ENSMUST00000205194.2 Gm44292 ENSMUST00000205194.2 Gm44292 (from geneSymbol) ENSMUST00000205194.1 uc291gpe.1 uc291gpe.2 uc291gpe.1 uc291gpe.2 
ENSMUST00000205195.2 Gm21940 ENSMUST00000205195.2 Gm21940 (from geneSymbol) ENSMUST00000205195.1 uc291jml.1 uc291jml.2 uc291jml.1 uc291jml.2 
ENSMUST00000205198.2 1700003I16Rik ENSMUST00000205198.2 1700003I16Rik (from geneSymbol) AK005642 ENSMUST00000205198.1 uc291kmb.1 uc291kmb.2 uc291kmb.1 uc291kmb.2 
ENSMUST00000205203.2 Gm44226 ENSMUST00000205203.2 Gm44226 (from geneSymbol) ENSMUST00000205203.1 uc291egy.1 uc291egy.2 uc291egy.1 uc291egy.2 
ENSMUST00000205210.3 Gm4872 ENSMUST00000205210.3 predicted gene 4872, transcript variant 1 (from RefSeq NR_073371.1) ENSMUST00000205210.1 ENSMUST00000205210.2 NR_073371 uc033irx.1 uc033irx.2 uc033irx.3 uc033irx.1 uc033irx.2 uc033irx.3 
ENSMUST00000205212.2 Gm44091 ENSMUST00000205212.2 Gm44091 (from geneSymbol) ENSMUST00000205212.1 uc291gqa.1 uc291gqa.2 uc291gqa.1 uc291gqa.2 
ENSMUST00000205219.2 Gm44199 ENSMUST00000205219.2 Gm44199 (from geneSymbol) ENSMUST00000205219.1 uc291hvw.1 uc291hvw.2 uc291hvw.1 uc291hvw.2 
ENSMUST00000205221.2 Gm44135 ENSMUST00000205221.2 Gm44135 (from geneSymbol) ENSMUST00000205221.1 uc291jku.1 uc291jku.2 uc291jku.1 uc291jku.2 
ENSMUST00000205226.2 B130021K23Rik ENSMUST00000205226.2 B130021K23Rik (from geneSymbol) AK038942 ENSMUST00000205226.1 uc291gsb.1 uc291gsb.2 uc291gsb.1 uc291gsb.2 
ENSMUST00000205229.2 Gm44178 ENSMUST00000205229.2 Gm44178 (from geneSymbol) ENSMUST00000205229.1 LF195699 uc291gwu.1 uc291gwu.2 uc291gwu.1 uc291gwu.2 
ENSMUST00000205235.2 Gm44266 ENSMUST00000205235.2 Gm44266 (from geneSymbol) ENSMUST00000205235.1 uc291jxc.1 uc291jxc.2 uc291jxc.1 uc291jxc.2 
ENSMUST00000205251.3 Lhx8 ENSMUST00000205251.3 LIM homeobox protein 8, transcript variant 4 (from RefSeq NM_001410062.1) ENSMUST00000205251.1 ENSMUST00000205251.2 H3BJ54 H3BJ54_MOUSE Lhx8 NM_001410062 uc290kta.1 uc290kta.2 Nucleus DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc290kta.1 uc290kta.2 
ENSMUST00000205259.2 Chst8 ENSMUST00000205259.2 Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin. (from UniProt Q8BQ86) AK051290 CHST8_MOUSE ENSMUST00000205259.1 Q76EC6 Q80XD4 Q8BQ86 uc291oli.1 uc291oli.2 Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin. Golgi apparatus membrane ; Single- pass type II membrane protein Strongly expressed in brain. Weakly expressed in lung and kidney. Weakly expressed in pituitary. Belongs to the sulfotransferase 2 family. Golgi membrane N-acetylgalactosamine 4-O-sulfotransferase activity Golgi apparatus carbohydrate metabolic process sulfur compound metabolic process sulfotransferase activity membrane integral component of membrane carbohydrate biosynthetic process peptide hormone processing transferase activity proteoglycan biosynthetic process hormone biosynthetic process uc291oli.1 uc291oli.2 
ENSMUST00000205262.2 Arhgap17 ENSMUST00000205262.2 Rho GTPase activating protein 17, transcript variant 6 (from RefSeq NM_001316713.1) ENSMUST00000205262.1 NM_001316713 Q3UDP7 Q3UIA2 Q8BGD1 Q99LH3 Q99N39 Q99N40 RHG17_MOUSE uc009jpk.1 uc009jpk.2 uc009jpk.3 uc009jpk.4 Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1 (By similarity). Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3. Interacts with NHERF1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP and SH3KBP1/CIN85 (By similarity). Membrane ; Peripheral membrane protein Cytoplasm Cell junction, tight junction Note=Associates with membranes and concentrates at sites of cell-cell contact. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Nadrin-1; IsoId=Q3UIA2-1; Sequence=Displayed; Name=2; Synonyms=Nadrin-2; IsoId=Q3UIA2-2; Sequence=VSP_023690; Name=3; IsoId=Q3UIA2-3; Sequence=VSP_023690, VSP_023691; Name=4; IsoId=Q3UIA2-4; Sequence=VSP_023690, VSP_023692; The BAR domain mediates the interaction with the coiled coil domain of AMOT, leading to its recruitment to tight junctions. GTPase activator activity nucleus cytoplasm cytosol plasma membrane bicellular tight junction actin filament organization signal transduction membrane SH3 domain binding calcium ion regulated exocytosis cell junction regulation of actin cytoskeleton organization positive regulation of GTPase activity Rac GTPase binding uc009jpk.1 uc009jpk.2 uc009jpk.3 uc009jpk.4 
ENSMUST00000205271.2 Dedd2 ENSMUST00000205271.2 May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. (from UniProt Q8QZV0) BC092250 DEDD2_MOUSE ENSMUST00000205271.1 Flame3 Q569Y9 Q8JZV1 Q8QZV0 uc291mxv.1 uc291mxv.2 May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Interacts with CASP8, CASP10 and GTF3C3. Homodimerizes and heterodimerizes with DEDD (By similarity). Nucleus, nucleolus Note=Nuclear, accumulated in subnuclear structures resembling nucleoli. Expression is high in liver, heart, kidney, and testis but low in brain, spleen, lung, and skeleton muscle. Interactions with CASP8 and CASP10 are mediated by the DED domain. DNA binding nucleus nucleolus apoptotic process extrinsic apoptotic signaling pathway via death domain receptors apoptotic nuclear changes regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway uc291mxv.1 uc291mxv.2 
ENSMUST00000205276.2 Emsy ENSMUST00000205276.2 EMSY, BRCA2-interacting transcriptional repressor, transcript variant 4 (from RefSeq NM_172280.2) EMSY_MOUSE ENSMUST00000205276.1 Emsy NM_172280 Q5FWK5 Q80XU1 Q8BMB0 Q8VDW9 uc009iko.1 uc009iko.2 uc009iko.3 uc009iko.4 Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (By similarity). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (By similarity). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). Homodimer (By similarity). Interacts with the transactivation domain of BRCA2 (PubMed:14651845). Interacts with CBX1 (via chromoshadow domain) (By similarity). Interacts with ZMYND11 (By similarity). Does not interact with CBX3 or CBX5 (By similarity). Component of a nuclear receptor-mediated transcription complex composed of at least ZNF335, CCAR2 and EMSY; the complex stimulates the transcription of nuclear receptor target genes such as SOX9 and HOXA1 (By similarity). Within the complex interacts with CCAR2 and ZNF335 (By similarity). Components of this complex may associate with components of a histone methylation complex to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5 (By similarity). Within this complex, interacts with ASH2L and RBBP5 (By similarity). Nucleus Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BMB0-1; Sequence=Displayed; Name=2; IsoId=Q8BMB0-2; Sequence=VSP_010433, VSP_010434; Name=3; IsoId=Q8BMB0-3; Sequence=VSP_010432; Sequence=AAH20109.1; Type=Erroneous initiation; Evidence=; Sequence=BC039956; Type=Frameshift; Evidence=; protein binding nucleus nucleoplasm DNA repair chromatin organization regulation of transcription, DNA-templated cellular response to DNA damage stimulus protein homodimerization activity uc009iko.1 uc009iko.2 uc009iko.3 uc009iko.4 
ENSMUST00000205280.2 Gm44894 ENSMUST00000205280.2 Gm44894 (from geneSymbol) ENSMUST00000205280.1 uc291qjb.1 uc291qjb.2 uc291qjb.1 uc291qjb.2 
ENSMUST00000205285.2 Gm10616 ENSMUST00000205285.2 Gm10616 (from geneSymbol) ENSMUST00000205285.1 LF196385 uc033jac.1 uc033jac.2 uc033jac.3 uc033jac.1 uc033jac.2 uc033jac.3 
ENSMUST00000205294.2 Gm44739 ENSMUST00000205294.2 Gm44739 (from geneSymbol) DQ719215 ENSMUST00000205294.1 uc291rlf.1 uc291rlf.2 uc291rlf.1 uc291rlf.2 
ENSMUST00000205302.3 Gm45004 ENSMUST00000205302.3 Gm45004 (from geneSymbol) ENSMUST00000205302.1 ENSMUST00000205302.2 uc291rlr.1 uc291rlr.2 uc291rlr.3 uc291rlr.1 uc291rlr.2 uc291rlr.3 
ENSMUST00000205307.2 Gm44725 ENSMUST00000205307.2 Gm44725 (from geneSymbol) ENSMUST00000205307.1 uc291rjm.1 uc291rjm.2 uc291rjm.1 uc291rjm.2 
ENSMUST00000205314.2 2700080J24Rik ENSMUST00000205314.2 2700080J24Rik (from geneSymbol) AK012542 ENSMUST00000205314.1 uc291mcx.1 uc291mcx.2 uc291mcx.1 uc291mcx.2 
ENSMUST00000205317.2 Gm44694 ENSMUST00000205317.2 Gm44694 (from geneSymbol) ENSMUST00000205317.1 uc291rng.1 uc291rng.2 uc291rng.1 uc291rng.2 
ENSMUST00000205319.3 Gm40457 ENSMUST00000205319.3 Gm40457 (from geneSymbol) ENSMUST00000205319.1 ENSMUST00000205319.2 uc291wcu.1 uc291wcu.2 uc291wcu.3 uc291wcu.1 uc291wcu.2 uc291wcu.3 
ENSMUST00000205356.2 Gm45020 ENSMUST00000205356.2 Gm45020 (from geneSymbol) ENSMUST00000205356.1 uc291urh.1 uc291urh.2 uc291urh.1 uc291urh.2 
ENSMUST00000205370.2 Particl ENSMUST00000205370.2 promoter of Mat2a antisense radiation induced circulating long non-coding RNA (from RefSeq NR_046011.1) ENSMUST00000205370.1 NR_046011 uc291fur.1 uc291fur.2 uc291fur.1 uc291fur.2 
ENSMUST00000205373.3 Or11h4b ENSMUST00000205373.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PXH6) E9PXH6 E9PXH6_MOUSE ENSMUST00000205373.1 ENSMUST00000205373.2 Olfr747 Or11h4b uc288tmd.1 uc288tmd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tmd.1 uc288tmd.2 
ENSMUST00000205380.2 ENSMUSG00000121337 ENSMUST00000205380.2 CEA cell adhesion molecule, pseudogene 1 (from RefSeq NR_003247.2) ENSMUST00000205380.1 NR_003247 uc012fai.1 uc012fai.2 uc012fai.3 uc012fai.1 uc012fai.2 uc012fai.3 
ENSMUST00000205388.2 Gm44684 ENSMUST00000205388.2 Gm44684 (from geneSymbol) ENSMUST00000205388.1 uc291nhb.1 uc291nhb.2 uc291nhb.1 uc291nhb.2 
ENSMUST00000205394.2 Gm44876 ENSMUST00000205394.2 Gm44876 (from geneSymbol) ENSMUST00000205394.1 uc291vhm.1 uc291vhm.2 uc291vhm.1 uc291vhm.2 
ENSMUST00000205395.2 Gm44770 ENSMUST00000205395.2 Gm44770 (from geneSymbol) ENSMUST00000205395.1 LF195555 uc291frq.1 uc291frq.2 uc291frq.1 uc291frq.2 
ENSMUST00000205396.2 Gm45121 ENSMUST00000205396.2 Gm45121 (from geneSymbol) ENSMUST00000205396.1 uc291wcw.1 uc291wcw.2 uc291wcw.1 uc291wcw.2 
ENSMUST00000205400.2 Gm44509 ENSMUST00000205400.2 Gm44509 (from geneSymbol) ENSMUST00000205400.1 uc291qkm.1 uc291qkm.2 uc291qkm.1 uc291qkm.2 
ENSMUST00000205403.2 2310043P16Rik ENSMUST00000205403.2 2310043P16Rik (from geneSymbol) AK044863 ENSMUST00000205403.1 uc291okv.1 uc291okv.2 uc291okv.1 uc291okv.2 
ENSMUST00000205409.2 Gm44780 ENSMUST00000205409.2 Gm44780 (from geneSymbol) ENSMUST00000205409.1 uc291pei.1 uc291pei.2 uc291pei.1 uc291pei.2 
ENSMUST00000205412.2 D530033B14Rik ENSMUST00000205412.2 D530033B14Rik (from geneSymbol) ENSMUST00000205412.1 uc291oql.1 uc291oql.2 uc291oql.1 uc291oql.2 
ENSMUST00000205414.2 Gm44711 ENSMUST00000205414.2 Gm44711 (from geneSymbol) ENSMUST00000205414.1 uc291hep.1 uc291hep.2 uc291hep.1 uc291hep.2 
ENSMUST00000205416.2 Gm44817 ENSMUST00000205416.2 Gm44817 (from geneSymbol) ENSMUST00000205416.1 uc291paw.1 uc291paw.2 uc291paw.1 uc291paw.2 
ENSMUST00000205418.2 Gm36696 ENSMUST00000205418.2 Gm36696 (from geneSymbol) ENSMUST00000205418.1 uc291rjb.1 uc291rjb.2 uc291rjb.1 uc291rjb.2 
ENSMUST00000205424.2 Zg16 ENSMUST00000205424.2 zymogen granule protein 16 (from RefSeq NM_026918.3) ENSMUST00000205424.1 NM_026918 Q8K0C5 ZG16_MOUSE uc291vsf.1 uc291vsf.2 May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN (By similarity). Secreted, extracellular space, extracellular matrix Zymogen granule lumen Golgi apparatus lumen Belongs to the jacalin lectin family. molecular_function extracellular region extracellular space Golgi apparatus Golgi lumen biological_process protein transport carbohydrate binding cytoplasmic vesicle zymogen granule membrane cytoplasmic vesicle lumen uc291vsf.1 uc291vsf.2 
ENSMUST00000205428.2 Kcnn4 ENSMUST00000205428.2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, transcript variant 10 (from RefSeq NR_182007.1) ENSMUST00000205428.1 KCNN4_MOUSE NR_182007 O89109 Q3U1J8 Q9CY39 uc009fpl.1 uc009fpl.2 uc009fpl.3 uc009fpl.4 Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:9705284). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:20884616). Plays a role in the late stages of EGF-induced macropinocytosis (By similarity). The channel is inhibited by clotrimazole and charybdotoxin but is insensitive to apamin. Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6 (By similarity). Cell membrane ; Multi-pass membrane protein Phosphorylation at His-356 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel. Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily. immune system process potassium channel activity calmodulin binding plasma membrane integral component of plasma membrane ion transport potassium ion transport calcium ion transport anion transport cell volume homeostasis calcium-activated potassium channel activity membrane integral component of membrane small conductance calcium-activated potassium channel activity basolateral plasma membrane apical plasma membrane protein phosphatase binding Intermediate conductance calcium-activated potassium channel activity stabilization of membrane potential vesicle neuron projection neuronal cell body membrane raft phospholipid translocation saliva secretion positive regulation of protein secretion positive regulation of T cell receptor signaling pathway potassium ion transmembrane transport potassium ion export across plasma membrane uc009fpl.1 uc009fpl.2 uc009fpl.3 uc009fpl.4 
ENSMUST00000205432.3 Fbrs ENSMUST00000205432.3 fibrosin (from RefSeq NM_010183.2) A0A1N9PTV1 A0A1N9PTV1_MOUSE ENSMUST00000205432.1 ENSMUST00000205432.2 Fbrs NM_010183 uc291vva.1 uc291vva.2 uc291vva.1 uc291vva.2 
ENSMUST00000205437.3 Cdiptos ENSMUST00000205437.3 CDIP transferase, opposite strand, transcript variant 5 (from RefSeq NM_001419608.1) A0A1D5RM53 A0A1D5RM53_MOUSE Cdiptos D830044I16Rik ENSMUST00000205437.1 ENSMUST00000205437.2 NM_001419608 uc291vqt.1 uc291vqt.2 molecular_function cellular_component biological_process uc291vqt.1 uc291vqt.2 
ENSMUST00000205445.2 Gm45151 ENSMUST00000205445.2 Gm45151 (from geneSymbol) ENSMUST00000205445.1 uc291utt.1 uc291utt.2 uc291utt.1 uc291utt.2 
ENSMUST00000205458.2 Gm44552 ENSMUST00000205458.2 Gm44552 (from geneSymbol) AK079885 ENSMUST00000205458.1 uc291rkg.1 uc291rkg.2 uc291rkg.1 uc291rkg.2 
ENSMUST00000205471.3 Or5h26 ENSMUST00000205471.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PYP4) E9PVC0 E9PYP4 E9PYP4_MOUSE E9Q6D1 ENSMUST00000205471.1 ENSMUST00000205471.2 Olfr190 Olfr191 Olfr196 Or5h26 uc289fgk.1 uc289fgk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289fgk.1 uc289fgk.2 
ENSMUST00000205476.2 Gm38569 ENSMUST00000205476.2 Gm38569 (from geneSymbol) AK042846 ENSMUST00000205476.1 uc291mzp.1 uc291mzp.2 uc291mzp.1 uc291mzp.2 
ENSMUST00000205492.2 Gm44645 ENSMUST00000205492.2 Gm44645 (from geneSymbol) ENSMUST00000205492.1 LF196370 uc291rjv.1 uc291rjv.2 uc291rjv.1 uc291rjv.2 
ENSMUST00000205493.2 Gm44854 ENSMUST00000205493.2 Gm44854 (from geneSymbol) AK085649 ENSMUST00000205493.1 uc291voy.1 uc291voy.2 uc291voy.1 uc291voy.2 
ENSMUST00000205501.2 Gm30191 ENSMUST00000205501.2 predicted gene, 30191, transcript variant 3 (from RefSeq NM_001372230.1) A0A0U1RNT7 A0A0U1RNT7_MOUSE ENSMUST00000205501.1 Gm30191 NM_001372230 uc290qss.1 uc290qss.2 uc290qss.1 uc290qss.2 
ENSMUST00000205529.2 Gm6567 ENSMUST00000205529.2 predicted gene 6567 (from RefSeq NR_046024.1) ENSMUST00000205529.1 NR_046024 uc029wil.1 uc029wil.2 uc029wil.3 uc029wil.1 uc029wil.2 uc029wil.3 
ENSMUST00000205532.2 Gm21284 ENSMUST00000205532.2 predicted gene, 21284 (from RefSeq NR_078345.1) ENSMUST00000205532.1 NR_078345 uc009cnu.1 uc009cnu.2 uc009cnu.3 uc009cnu.4 uc009cnu.1 uc009cnu.2 uc009cnu.3 uc009cnu.4 
ENSMUST00000205533.3 Gm45218 ENSMUST00000205533.3 Gm45218 (from geneSymbol) AK148329 ENSMUST00000205533.1 ENSMUST00000205533.2 uc009cyf.1 uc009cyf.2 uc009cyf.3 uc009cyf.4 uc009cyf.1 uc009cyf.2 uc009cyf.3 uc009cyf.4 
ENSMUST00000205544.2 Gm44835 ENSMUST00000205544.2 Gm44835 (from geneSymbol) ENSMUST00000205544.1 uc291rmt.1 uc291rmt.2 uc291rmt.1 uc291rmt.2 
ENSMUST00000205547.2 Gm45216 ENSMUST00000205547.2 Gm45216 (from geneSymbol) ENSMUST00000205547.1 uc291hdm.1 uc291hdm.2 uc291hdm.1 uc291hdm.2 
ENSMUST00000205549.2 Gm44981 ENSMUST00000205549.2 Gm44981 (from geneSymbol) ENSMUST00000205549.1 LF195729 uc291hdx.1 uc291hdx.2 uc291hdx.1 uc291hdx.2 
ENSMUST00000205557.2 Gm39041 ENSMUST00000205557.2 Gm39041 (from geneSymbol) AK051494 ENSMUST00000205557.1 uc291rpy.1 uc291rpy.2 uc291rpy.1 uc291rpy.2 
ENSMUST00000205558.2 Gm45059 ENSMUST00000205558.2 Gm45059 (from geneSymbol) ENSMUST00000205558.1 LF196379 uc291roq.1 uc291roq.2 uc291roq.1 uc291roq.2 
ENSMUST00000205565.2 Gm44746 ENSMUST00000205565.2 Gm44746 (from geneSymbol) AK042390 ENSMUST00000205565.1 uc291veq.1 uc291veq.2 uc291veq.1 uc291veq.2 
ENSMUST00000205567.2 Gm44695 ENSMUST00000205567.2 Gm44695 (from geneSymbol) ENSMUST00000205567.1 uc291rms.1 uc291rms.2 uc291rms.1 uc291rms.2 
ENSMUST00000205568.2 Maz ENSMUST00000205568.2 MYC-associated zinc finger protein (purine-binding transcription factor), transcript variant 9 (from RefSeq NM_001412681.1) A0A0U1RNL9 A0A0U1RNL9_MOUSE ENSMUST00000205568.1 Maz NM_001412681 uc291vrt.1 uc291vrt.2 nucleic acid binding uc291vrt.1 uc291vrt.2 
ENSMUST00000205573.2 Xrcc1 ENSMUST00000205573.2 X-ray repair complementing defective repair in Chinese hamster cells 1, transcript variant 1 (from RefSeq NM_009532.5) ENSMUST00000205573.1 NM_009532 Q3THC5 Q5U435 Q60596 Q7TNQ5 XRCC1_MOUSE Xrcc-1 uc009fpx.1 uc009fpx.2 uc009fpx.3 uc009fpx.4 Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (By similarity). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (By similarity). Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1. Interacts with (poly-ADP- ribosylated) PARP1. Nucleus Chromosome Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage. Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains. Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF (By similarity). Sumoylated. Embryonic lethal. Conditional knockout in brain causes cerebellar histopathology including increased apoptosis of cerebellar granule neurons, reduced numbers of cerebellar interneurons and decreased electrophysiological spike activity in Purkinje cells. Mutant mice exhibit cerebellar ataxia and elevated levels of ADP-ribose in cerebellum. Double knockout with PARP1 restores the normal interneuron density and ADP-ribose levels, reducing cerebellar ataxia in comparison to the single XRCC1 knockout mice. single strand break repair nuclear chromosome, telomeric region nuclear chromatin response to hypoxia damaged DNA binding nucleus nucleolus DNA repair base-excision repair double-strand break repair via nonhomologous end joining cellular response to DNA damage stimulus response to organic substance negative regulation of protein ADP-ribosylation enzyme binding cerebellum morphogenesis hippocampus development oxidized DNA binding response to hydroperoxide response to drug voluntary musculoskeletal movement telomeric DNA-containing double minutes formation ERCC4-ERCC1 complex positive regulation of single strand break repair positive regulation of DNA ligase activity negative regulation of protection from non-homologous end joining at telomere replication-born double-strand break repair via sister chromatid exchange 3' overhang single-stranded DNA endodeoxyribonuclease activity uc009fpx.1 uc009fpx.2 uc009fpx.3 uc009fpx.4 
ENSMUST00000205574.2 Gm44806 ENSMUST00000205574.2 Gm44806 (from geneSymbol) AK053401 ENSMUST00000205574.1 uc291opo.1 uc291opo.2 uc291opo.1 uc291opo.2 
ENSMUST00000205577.2 Kctd14 ENSMUST00000205577.2 potassium channel tetramerisation domain containing 14, transcript variant 3 (from RefSeq NM_001010826.3) ENSMUST00000205577.1 Kctd14 NM_001010826 Q5EER8 Q5EER8_MOUSE uc012fpi.1 uc012fpi.2 uc012fpi.3 molecular_function cellular_component biological_process protein homooligomerization uc012fpi.1 uc012fpi.2 uc012fpi.3 
ENSMUST00000205580.2 Gm44708 ENSMUST00000205580.2 Gm44708 (from geneSymbol) AK051340 ENSMUST00000205580.1 uc291qls.1 uc291qls.2 uc291qls.1 uc291qls.2 
ENSMUST00000205591.3 Gm45168 ENSMUST00000205591.3 Gm45168 (from geneSymbol) ENSMUST00000205591.1 ENSMUST00000205591.2 uc291rrk.1 uc291rrk.2 uc291rrk.3 uc291rrk.1 uc291rrk.2 uc291rrk.3 
ENSMUST00000205603.2 Gm44740 ENSMUST00000205603.2 Gm44740 (from geneSymbol) AK157608 ENSMUST00000205603.1 uc291vcq.1 uc291vcq.2 uc291vcq.1 uc291vcq.2 
ENSMUST00000205611.2 Gm44607 ENSMUST00000205611.2 Gm44607 (from geneSymbol) AK041126 ENSMUST00000205611.1 uc291rnz.1 uc291rnz.2 uc291rnz.1 uc291rnz.2 
ENSMUST00000205621.2 Gm44850 ENSMUST00000205621.2 Gm44850 (from geneSymbol) AK135679 ENSMUST00000205621.1 uc291waw.1 uc291waw.2 uc291waw.1 uc291waw.2 
ENSMUST00000205631.3 Or2b6 ENSMUST00000205631.3 Odorant receptor. (from UniProt Q60890) ENSMUST00000205631.1 ENSMUST00000205631.2 Mor256-11 OR2B6_MOUSE Olfr11 Or2b6 Q60890 Q7TQU3 Q8VFH1 uc288lfj.1 uc288lfj.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288lfj.1 uc288lfj.2 
ENSMUST00000205637.2 Gm44613 ENSMUST00000205637.2 Gm44613 (from geneSymbol) ENSMUST00000205637.1 uc291meo.1 uc291meo.2 uc291meo.1 uc291meo.2 
ENSMUST00000205645.2 Gm44567 ENSMUST00000205645.2 Gm44567 (from geneSymbol) AK051745 ENSMUST00000205645.1 uc291okr.1 uc291okr.2 uc291okr.1 uc291okr.2 
ENSMUST00000205646.3 4931431B13Rik ENSMUST00000205646.3 RIKEN cDNA 4931431B13 gene (from RefSeq NR_045183.1) ENSMUST00000205646.1 ENSMUST00000205646.2 NR_045183 uc009jyh.1 uc009jyh.2 uc009jyh.3 uc009jyh.1 uc009jyh.2 uc009jyh.3 
ENSMUST00000205658.2 B9d2 ENSMUST00000205658.2 B9 protein domain 2, transcript variant 1 (from RefSeq NM_001362154.1) B9D2_MOUSE ENSMUST00000205658.1 NM_001362154 Q3UK10 Q8R045 uc009fto.1 uc009fto.2 Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Part of the tectonic-like complex (also named B9 complex). Interacts with TUBG1. Q3UK10; Q9R1S0: B9d1; NbExp=5; IntAct=EBI-5652008, EBI-5652050; Q3UK10; Q5SW45: Mks1; NbExp=3; IntAct=EBI-5652008, EBI-4281059; Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, cilium axoneme Nucleus Highest expression in thymus and skeletal muscle. Also expressed in spleen, kidney, lung, heart, microglia and liver. Detected in brain (at protein level). Mice expressing reduced levels of the protein in the central nervous system and kidney develop perinatal triventricular hydrocephaly, polycystic kidney disease, lack functional intact cilia and die at the time of weaning. Belongs to the B9D family. protein binding nucleus cytoplasm centrosome cytoskeleton cilium membrane cell projection organization MKS complex ciliary basal body cell projection gamma-tubulin binding cilium assembly uc009fto.1 uc009fto.2 
ENSMUST00000205662.3 Gm15873 ENSMUST00000205662.3 Gm15873 (from geneSymbol) AK131696 ENSMUST00000205662.1 ENSMUST00000205662.2 uc009exx.1 uc009exx.2 uc009exx.3 uc009exx.1 uc009exx.2 uc009exx.3 
ENSMUST00000205671.2 Zfp626 ENSMUST00000205671.2 zinc finger protein 626, transcript variant 2 (from RefSeq NM_027703.2) A0A0U1RQ84 A0A0U1RQ84_MOUSE ENSMUST00000205671.1 NM_027703 Zfp626 uc009fxd.1 uc009fxd.2 uc009fxd.3 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc009fxd.1 uc009fxd.2 uc009fxd.3 
ENSMUST00000205686.2 4930590J08Rik ENSMUST00000205686.2 RIKEN cDNA 4930590J08 gene (from RefSeq NM_198668.2) CC020_MOUSE ENSMUST00000205686.1 NM_198668 Q8CDN1 uc009cyl.1 uc009cyl.2 Membrane ; Single-pass membrane protein molecular_function cytoplasm biological_process membrane integral component of membrane uc009cyl.1 uc009cyl.2 
ENSMUST00000205692.2 Gm44673 ENSMUST00000205692.2 Gm44673 (from geneSymbol) AK038032 ENSMUST00000205692.1 uc291wdj.1 uc291wdj.2 uc291wdj.1 uc291wdj.2 
ENSMUST00000205693.2 A830073O21Rik ENSMUST00000205693.2 A830073O21Rik (from geneSymbol) AK080460 ENSMUST00000205693.1 uc291rli.1 uc291rli.2 uc291rli.1 uc291rli.2 
ENSMUST00000205694.2 Rnf40 ENSMUST00000205694.2 ring finger protein 40, transcript variant 1 (from RefSeq NM_172281.3) BRE1B_MOUSE Bre1b ENSMUST00000205694.1 Kiaa0661 NM_172281 Q3U319 Q6ZQ75 Q8BJA1 Q8BY03 Q8CHX4 uc009jwe.1 uc009jwe.2 uc009jwe.3 uc009jwe.4 Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with RB1 and WAC. Nucleus Belongs to the BRE1 family. Sequence=BAC97994.1; Type=Erroneous initiation; Evidence=; ubiquitin ligase complex mRNA 3'-UTR binding ubiquitin-protein transferase activity protein binding nucleus nucleoplasm cytosol chromatin organization ubiquitin-dependent protein catabolic process histone monoubiquitination protein ubiquitination transferase activity syntaxin-1 binding extrinsic component of membrane ubiquitin conjugating enzyme binding ubiquitin protein ligase binding macromolecular complex HULC complex histone H2B ubiquitination protein homodimerization activity neuron projection response to peptide hormone axon terminus macromolecular complex binding metal ion binding negative regulation of mRNA polyadenylation positive regulation of proteasomal protein catabolic process positive regulation of protein polyubiquitination positive regulation of histone H2B ubiquitination uc009jwe.1 uc009jwe.2 uc009jwe.3 uc009jwe.4 
ENSMUST00000205701.2 Zfp59 ENSMUST00000205701.2 zinc finger protein 59 (from RefSeq NM_011762.4) ENSMUST00000205701.1 F8VPX4 Mfg2 NM_011762 P16373 Q61849 ZFP59_MOUSE uc009fxf.1 uc009fxf.2 uc009fxf.3 The Krueppel-associated box (KRAB) is a domain of around 75 amino acids found in the N-terminal portion of about one third of eukaryotic Krueppel-type C2H2 zinc finger proteins (ZFPs). The KRAB domain functions as a transcriptional repressor when tethered to the template DNA by a DNA-binding domain. Although the function of KRAB-ZFPs is largely unknown, they appear to play important roles during cell differentiation and development. This gene encodes a protein belonging to the Krueppel family of C2H2-type zinc finger proteins and has been shown to accumulate in the nuclei of mature sperm in association with the nuclear matrix. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CK391660.1, SRR1660817.33513.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## May have a role during differentiation processes. Nucleus Expressed predominantly in the testis (at protein level). Expression is positively regulated upon differentiation. Is specifically synthesized during postmeiotic phase of male germline differentiation. Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAA39532.1; Type=Frameshift; Evidence=; Sequence=AAA39532.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence=; Sequence=AAA92741.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAA92741.1; Type=Frameshift; Evidence=; Sequence=AAA92741.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence=; nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009fxf.1 uc009fxf.2 uc009fxf.3 
ENSMUST00000205702.2 Gm44882 ENSMUST00000205702.2 Gm44882 (from geneSymbol) ENSMUST00000205702.1 uc291opr.1 uc291opr.2 uc291opr.1 uc291opr.2 
ENSMUST00000205704.2 Gm45110 ENSMUST00000205704.2 Gm45110 (from geneSymbol) ENSMUST00000205704.1 uc291vuq.1 uc291vuq.2 uc291vuq.1 uc291vuq.2 
ENSMUST00000205707.2 C130083A15Rik ENSMUST00000205707.2 C130083A15Rik (from geneSymbol) AK149566 ENSMUST00000205707.1 uc291rkm.1 uc291rkm.2 uc291rkm.1 uc291rkm.2 
ENSMUST00000205715.2 Zfp607a ENSMUST00000205715.2 Belongs to the krueppel C2H2-type zinc-finger protein family. (from UniProt Q3TQG9) BC042662 ENSMUST00000205715.1 Q3TQG9 Q3TQG9_MOUSE Zfp607 Zfp607a uc291nho.1 uc291nho.2 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc291nho.1 uc291nho.2 
ENSMUST00000205727.3 Or5h24 ENSMUST00000205727.3 olfactory receptor 192, transcript variant 2 (from RefSeq NR_157091.1) ENSMUST00000205727.1 ENSMUST00000205727.2 NR_157091 uc289fgd.1 uc289fgd.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. uc289fgd.1 uc289fgd.2 
ENSMUST00000205735.2 Gm44851 ENSMUST00000205735.2 predicted gene 44851 (from RefSeq NR_169037.1) ENSMUST00000205735.1 NR_169037 uc291rwg.1 uc291rwg.2 uc291rwg.1 uc291rwg.2 
ENSMUST00000205745.2 Gm45205 ENSMUST00000205745.2 Gm45205 (from geneSymbol) ENSMUST00000205745.1 LF196627 uc291wab.1 uc291wab.2 uc291wab.1 uc291wab.2 
ENSMUST00000205759.2 5330411O13Rik ENSMUST00000205759.2 5330411O13Rik (from geneSymbol) AK017240 ENSMUST00000205759.1 uc291row.1 uc291row.2 uc291row.1 uc291row.2 
ENSMUST00000205762.2 1700011D18Rik ENSMUST00000205762.2 1700011D18Rik (from geneSymbol) AK005859 ENSMUST00000205762.1 uc291roz.1 uc291roz.2 uc291roz.1 uc291roz.2 
ENSMUST00000205766.3 Or5h20-ps1 ENSMUST00000205766.3 Or5h20-ps1 (from geneSymbol) ENSMUST00000205766.1 ENSMUST00000205766.2 uc289ffx.1 uc289ffx.2 uc289ffx.1 uc289ffx.2 
ENSMUST00000205776.2 Irgc ENSMUST00000205776.2 immunity related GTPase cinema, transcript variant 3 (from RefSeq NM_199013.2) D3Z720 D3Z720_MOUSE ENSMUST00000205776.1 Ifgge Irgc Irgc1 NM_199013 uc009fpp.1 uc009fpp.2 uc009fpp.3 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. GTP binding membrane uc009fpp.1 uc009fpp.2 uc009fpp.3 
ENSMUST00000205793.2 Gm45136 ENSMUST00000205793.2 Gm45136 (from geneSymbol) AK156160 ENSMUST00000205793.1 uc291pcm.1 uc291pcm.2 uc291pcm.1 uc291pcm.2 
ENSMUST00000205810.2 Gm45058 ENSMUST00000205810.2 Gm45058 (from geneSymbol) BC126915 ENSMUST00000205810.1 uc291mgp.1 uc291mgp.2 uc291mgp.1 uc291mgp.2 
ENSMUST00000205812.3 Gm44878 ENSMUST00000205812.3 Gm44878 (from geneSymbol) AK051120 ENSMUST00000205812.1 ENSMUST00000205812.2 uc291kvq.1 uc291kvq.2 uc291kvq.3 uc291kvq.1 uc291kvq.2 uc291kvq.3 
ENSMUST00000205831.2 Gm45212 ENSMUST00000205831.2 Gm45212 (from geneSymbol) DQ685504 ENSMUST00000205831.1 uc057ahq.1 uc057ahq.2 uc057ahq.3 uc057ahq.1 uc057ahq.2 uc057ahq.3 
ENSMUST00000205836.2 Gm33248 ENSMUST00000205836.2 Gm33248 (from geneSymbol) ENSMUST00000205836.1 uc291wej.1 uc291wej.2 uc291wej.1 uc291wej.2 
ENSMUST00000205844.3 Gm39094 ENSMUST00000205844.3 Gm39094 (from geneSymbol) ENSMUST00000205844.1 ENSMUST00000205844.2 uc291weh.1 uc291weh.2 uc291weh.3 uc291weh.1 uc291weh.2 uc291weh.3 
ENSMUST00000205846.2 Gm45191 ENSMUST00000205846.2 Gm45191 (from geneSymbol) AK141094 ENSMUST00000205846.1 uc291vei.1 uc291vei.2 uc291vei.1 uc291vei.2 
ENSMUST00000205847.2 Gm44646 ENSMUST00000205847.2 Gm44646 (from geneSymbol) ENSMUST00000205847.1 uc291pfw.1 uc291pfw.2 uc291pfw.1 uc291pfw.2 
ENSMUST00000205855.2 Gm36694 ENSMUST00000205855.2 Gm36694 (from geneSymbol) AK135913 ENSMUST00000205855.1 uc291mso.1 uc291mso.2 uc291mso.1 uc291mso.2 
ENSMUST00000205859.2 Gm44639 ENSMUST00000205859.2 Gm44639 (from geneSymbol) ENSMUST00000205859.1 LF300260 uc291rpx.1 uc291rpx.2 uc291rpx.1 uc291rpx.2 
ENSMUST00000205869.2 Gm44836 ENSMUST00000205869.2 Gm44836 (from geneSymbol) ENSMUST00000205869.1 uc291olv.1 uc291olv.2 uc291olv.1 uc291olv.2 
ENSMUST00000205873.2 Gm36633 ENSMUST00000205873.2 predicted gene, 36633 (from RefSeq NR_126483.1) ENSMUST00000205873.1 NR_126483 uc009hno.1 uc009hno.2 uc009hno.3 uc009hno.1 uc009hno.2 uc009hno.3 
ENSMUST00000205875.2 Gm45003 ENSMUST00000205875.2 Gm45003 (from geneSymbol) AK083068 ENSMUST00000205875.1 uc291rlo.1 uc291rlo.2 uc291rlo.1 uc291rlo.2 
ENSMUST00000205892.2 4933435G04Rik ENSMUST00000205892.2 4933435G04Rik (from geneSymbol) DQ694891 ENSMUST00000205892.1 uc291rjn.1 uc291rjn.2 uc291rjn.1 uc291rjn.2 
ENSMUST00000205900.3 Or4e2 ENSMUST00000205900.3 Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanethiol (MTMT) and bis(methylthiomethyl) disulfide (PubMed:22328155, PubMed:25185561, PubMed:25901328, PubMed:29659735). Also binds odorants cis-cyclooctene and tert-butyl mercaptan (PubMed:27019154). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Potential). (from UniProt Q7TQQ0) A0A0U1RP41 ENSMUST00000205900.1 ENSMUST00000205900.2 MOR244-3 MOR83 OR4E2_MOUSE Olfr1509 Or4e2 Q7TQQ0 Q9R0K3 uc288tvp.1 uc288tvp.2 Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanethiol (MTMT) and bis(methylthiomethyl) disulfide (PubMed:22328155, PubMed:25185561, PubMed:25901328, PubMed:29659735). Also binds odorants cis-cyclooctene and tert-butyl mercaptan (PubMed:27019154). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Potential). Copper binding enhances receptor activity in response to odorant binding. Cell membrane ulti-pass membrane protein Expressed in olfactory epithelium, specifically in the olfactory sensory neurons of the septal organ. Detected at very low levels at 18 dpc and increased to its maximum level of expression by 7 days after birth in olfactory sensory neurons of the septal organ. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity copper ion binding odorant binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane metal ion binding response to stimulus detection of chemical stimulus involved in sensory perception detection of chemical stimulus involved in sensory perception of smell uc288tvp.1 uc288tvp.2 
ENSMUST00000205902.2 Gm44730 ENSMUST00000205902.2 Gm44730 (from geneSymbol) ENSMUST00000205902.1 uc291rpa.1 uc291rpa.2 uc291rpa.1 uc291rpa.2 
ENSMUST00000205913.2 A730082K24Rik ENSMUST00000205913.2 RIKEN cDNA A730082K24 gene, transcript variant 1 (from RefSeq NR_040317.1) ENSMUST00000205913.1 NR_040317 uc009jim.1 uc009jim.2 uc009jim.3 uc009jim.4 uc009jim.1 uc009jim.2 uc009jim.3 uc009jim.4 
ENSMUST00000205915.2 Plin1 ENSMUST00000205915.2 Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. (from UniProt Q8CGN5) BC096685 ENSMUST00000205915.1 PLIN1_MOUSE Peri Plin Q4V9U2 Q8C0F5 Q8CGN5 uc009hyv.1 uc009hyv.2 uc009hyv.3 uc009hyv.4 Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. Interacts with ABHD5 (PubMed:15292255). Interacts with CIDEC (PubMed:23481402). Interacts with AQP7 (By similarity). Endoplasmic reticulum Lipid droplet Note=Lipid droplet surface-associated. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Peri A; IsoId=Q8CGN5-1; Sequence=Displayed; Name=2; Synonyms=Peri B; IsoId=Q8CGN5-2; Sequence=VSP_038208, VSP_038209; Name=3; Synonyms=Peri C; IsoId=Q8CGN5-3; Sequence=VSP_038206, VSP_038207; Name=4; Synonyms=Peri D; IsoId=Q8CGN5-4; Sequence=VSP_038204, VSP_038205; Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity). Belongs to the perilipin family. Name=Protein Spotlight; Note=Fat, wonderful fat - Issue 10 of May 2001; URL="https://web.expasy.org/spotlight/back_issues/010"; protein binding endoplasmic reticulum lipid particle cytosol lipid metabolic process lipid catabolic process uc009hyv.1 uc009hyv.2 uc009hyv.3 uc009hyv.4 
ENSMUST00000205924.2 Gm31897 ENSMUST00000205924.2 Gm31897 (from geneSymbol) ENSMUST00000205924.1 uc291vtu.1 uc291vtu.2 uc291vtu.1 uc291vtu.2 
ENSMUST00000205931.2 Btnl12 ENSMUST00000205931.2 butyrophilin-like 12 (from RefSeq NM_001370898.1) A0A0U1RPM1 A0A0U1RPM1_MOUSE Btnl12 ENSMUST00000205931.1 Gm36028 NM_001370898 uc289eos.1 uc289eos.2 receptor binding external side of plasma membrane regulation of immune response T cell receptor signaling pathway uc289eos.1 uc289eos.2 
ENSMUST00000205934.2 Gm44898 ENSMUST00000205934.2 Gm44898 (from geneSymbol) AK140678 ENSMUST00000205934.1 uc291qjf.1 uc291qjf.2 uc291qjf.1 uc291qjf.2 
ENSMUST00000205943.2 Gm44736 ENSMUST00000205943.2 Gm44736 (from geneSymbol) ENSMUST00000205943.1 uc291rle.1 uc291rle.2 uc291rle.1 uc291rle.2 
ENSMUST00000205955.2 Gm45202 ENSMUST00000205955.2 Gm45202 (from geneSymbol) ENSMUST00000205955.1 uc291rta.1 uc291rta.2 uc291rta.1 uc291rta.2 
ENSMUST00000205956.2 Lrrc32 ENSMUST00000205956.2 leucine rich repeat containing 32 (from RefSeq NM_001113379.2) A0A0U1RQ93 ENSMUST00000205956.1 G3XA59 LRC32_MOUSE Lrrc32 NM_001113379 uc291swu.1 uc291swu.2 Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:25127859). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:25127859, PubMed:28912269). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (By similarity). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:25127859). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (PubMed:28912269). Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1 (By similarity). Interacts with TGFB2 (By similarity). Interacts with TGFB3; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB3, leading to regulate activation of TGF-beta-3 (PubMed:28912269). Interacts with LAPTM4B; decreases TGFB1 production in regulatory T-cells (By similarity). Cell membrane ; Single-pass type I membrane protein Cell surface Present in medial edge epithelial cells at 14.5 dpc (at protein level). Lethality within 24 hours after birth (PubMed:28912269). Mice display defective palatogenesis without apparent abnormalities in other major organs (PubMed:28912269). Belongs to the LRRC32/LRRC33 family. extracellular space nucleoplasm plasma membrane transforming growth factor beta receptor signaling pathway cell surface positive regulation of gene expression membrane integral component of membrane growth factor binding extracellular matrix negative regulation of activated T cell proliferation transforming growth factor beta binding negative regulation of cytokine secretion regulation of transforming growth factor beta activation regulation of transforming growth factor beta3 activation uc291swu.1 uc291swu.2 
ENSMUST00000205957.2 Gm45153 ENSMUST00000205957.2 Gm45153 (from geneSymbol) AK089517 ENSMUST00000205957.1 uc291uub.1 uc291uub.2 uc291uub.1 uc291uub.2 
ENSMUST00000205970.2 Gm44997 ENSMUST00000205970.2 Gm44997 (from geneSymbol) ENSMUST00000205970.1 uc291oxp.1 uc291oxp.2 uc291oxp.1 uc291oxp.2 
ENSMUST00000205973.2 C430039J01Rik ENSMUST00000205973.2 C430039J01Rik (from geneSymbol) ENSMUST00000205973.1 uc291uto.1 uc291uto.2 uc291uto.1 uc291uto.2 
ENSMUST00000205986.4 Or5k17 ENSMUST00000205986.4 Potential odorant receptor. (from UniProt Q8VGQ7) E9QKY8 ENSMUST00000205986.1 ENSMUST00000205986.2 ENSMUST00000205986.3 Mor184-4 O5K17_MOUSE Olfr181 Or5k17 Q05A60 Q7TS47 Q8VGQ7 uc029sxv.1 uc029sxv.2 uc029sxv.3 uc029sxv.4 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Sequence=AAP70774.1; Type=Erroneous initiation; Evidence=; G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc029sxv.1 uc029sxv.2 uc029sxv.3 uc029sxv.4 
ENSMUST00000205998.2 4930413G21Rik ENSMUST00000205998.2 RIKEN cDNA 4930413G21 gene (from RefSeq NR_045614.1) ENSMUST00000205998.1 NR_045614 uc029wof.1 uc029wof.2 uc029wof.3 uc029wof.1 uc029wof.2 uc029wof.3 
ENSMUST00000206001.2 Gm12784 ENSMUST00000206001.2 Gm12784 (from geneSymbol) AK144615 ENSMUST00000206001.1 uc291okz.1 uc291okz.2 uc291okz.1 uc291okz.2 
ENSMUST00000206007.2 Gm9768 ENSMUST00000206007.2 Gm9768 (from geneSymbol) AK192888 ENSMUST00000206007.1 uc057bsz.1 uc057bsz.2 uc057bsz.3 uc057bsz.1 uc057bsz.2 uc057bsz.3 
ENSMUST00000206009.3 Or2t1 ENSMUST00000206009.3 olfactory receptor family 2 subfamily T member 1 (from RefSeq NM_147027.2) E9Q3K2 E9Q3K2_MOUSE ENSMUST00000206009.1 ENSMUST00000206009.2 NM_147027 Olfr31 Or2t1 uc288qxa.1 uc288qxa.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript is intronless :: BC106819.1, BC106818.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288qxa.1 uc288qxa.2 
ENSMUST00000206013.4 4930571K23Rik ENSMUST00000206013.4 RIKEN cDNA 4930571K23 gene (from RefSeq NM_001145759.1) ENSMUST00000206013.1 ENSMUST00000206013.2 ENSMUST00000206013.3 NM_001145759 uc291vhd.1 uc291vhd.2 uc291vhd.3 uc291vhd.4 uc291vhd.1 uc291vhd.2 uc291vhd.3 uc291vhd.4 
ENSMUST00000206025.4 Gm44734 ENSMUST00000206025.4 Gm44734 (from geneSymbol) ENSMUST00000206025.1 ENSMUST00000206025.2 ENSMUST00000206025.3 uc291rkz.1 uc291rkz.2 uc291rkz.3 uc291rkz.4 uc291rkz.1 uc291rkz.2 uc291rkz.3 uc291rkz.4 
ENSMUST00000206031.2 Gm39075 ENSMUST00000206031.2 Gm39075 (from geneSymbol) ENSMUST00000206031.1 uc291uua.1 uc291uua.2 uc291uua.1 uc291uua.2 
ENSMUST00000206036.2 Gm29918 ENSMUST00000206036.2 Gm29918 (from geneSymbol) ENSMUST00000206036.1 uc291mzn.1 uc291mzn.2 uc291mzn.1 uc291mzn.2 
ENSMUST00000206043.2 Gm45025 ENSMUST00000206043.2 Gm45025 (from geneSymbol) AK030226 ENSMUST00000206043.1 uc291urz.1 uc291urz.2 uc291urz.1 uc291urz.2 
ENSMUST00000206054.2 Gm45172 ENSMUST00000206054.2 Gm45172 (from geneSymbol) ENSMUST00000206054.1 uc291ouo.1 uc291ouo.2 uc291ouo.1 uc291ouo.2 
ENSMUST00000206056.2 Gm44931 ENSMUST00000206056.2 Gm44931 (from geneSymbol) ENSMUST00000206056.1 LF196401 uc291rwu.1 uc291rwu.2 uc291rwu.1 uc291rwu.2 
ENSMUST00000206057.2 Gm44759 ENSMUST00000206057.2 Gm44759 (from geneSymbol) ENSMUST00000206057.1 uc291vwl.1 uc291vwl.2 uc291vwl.1 uc291vwl.2 
ENSMUST00000206058.2 Or4l1 ENSMUST00000206058.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PZU2) E9PZU2 E9PZU2_MOUSE E9Q322 ENSMUST00000206058.1 Olfr723 Or4l1 uc288tka.1 uc288tka.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tka.1 uc288tka.2 
ENSMUST00000206060.3 Gm36736 ENSMUST00000206060.3 Gm36736 (from geneSymbol) ENSMUST00000206060.1 ENSMUST00000206060.2 uc291vcj.1 uc291vcj.2 uc291vcj.3 uc291vcj.1 uc291vcj.2 uc291vcj.3 
ENSMUST00000206062.4 Or4e5 ENSMUST00000206062.4 olfactory receptor family 4 subfamily E member 5, transcript variant 1 (from RefSeq NM_001170918.1) A0A0U1RPW5 ENSMUST00000206062.1 ENSMUST00000206062.2 ENSMUST00000206062.3 F7C854 NM_001170918 Olfr1507 Or4e5 Q0VEP0 Q0VEP0_MOUSE uc011zko.1 uc011zko.2 uc011zko.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc011zko.1 uc011zko.2 uc011zko.3 
ENSMUST00000206063.2 Gm44883 ENSMUST00000206063.2 Gm44883 (from geneSymbol) AK051810 ENSMUST00000206063.1 uc291opu.1 uc291opu.2 uc291opu.1 uc291opu.2 
ENSMUST00000206065.2 Gm45213 ENSMUST00000206065.2 Belongs to the U2 small nuclear ribonucleoprotein A family. (from UniProt A0A0U1RNZ6) A0A0U1RNZ6 A0A0U1RNZ6_MOUSE AH005807 ENSMUST00000206065.1 Gm45213 uc291rau.1 uc291rau.2 Belongs to the U2 small nuclear ribonucleoprotein A family. mRNA splicing, via spliceosome U2 snRNP U2 snRNA binding uc291rau.1 uc291rau.2 
ENSMUST00000206078.2 Gm45006 ENSMUST00000206078.2 Gm45006 (from geneSymbol) AK076957 ENSMUST00000206078.1 uc291rln.1 uc291rln.2 uc291rln.1 uc291rln.2 
ENSMUST00000206080.2 5430434F05Rik ENSMUST00000206080.2 5430434F05Rik (from geneSymbol) ENSMUST00000206080.1 uc291gfm.1 uc291gfm.2 uc291gfm.1 uc291gfm.2 
ENSMUST00000206082.2 Gm45082 ENSMUST00000206082.2 Gm45082 (from geneSymbol) ENSMUST00000206082.1 uc291qzg.1 uc291qzg.2 uc291qzg.1 uc291qzg.2 
ENSMUST00000206086.2 Gm30437 ENSMUST00000206086.2 Gm30437 (from geneSymbol) ENSMUST00000206086.1 uc291hcw.1 uc291hcw.2 uc291hcw.1 uc291hcw.2 
ENSMUST00000206092.2 Hapln3 ENSMUST00000206092.2 hyaluronan and proteoglycan link protein 3 (from RefSeq NM_178255.3) ENSMUST00000206092.1 HPLN3_MOUSE Lpr3 NM_178255 Q3UVT2 Q80WM5 Q80XX3 uc009hxy.1 uc009hxy.2 uc009hxy.3 May function in hyaluronic acid binding. Secreted, extracellular space, extracellular matrix Belongs to the HAPLN family. skeletal system development hyaluronic acid binding extracellular region cell adhesion central nervous system development extracellular matrix uc009hxy.1 uc009hxy.2 uc009hxy.3 
ENSMUST00000206096.2 Gm44758 ENSMUST00000206096.2 Gm44758 (from geneSymbol) ENSMUST00000206096.1 uc291rju.1 uc291rju.2 uc291rju.1 uc291rju.2 
ENSMUST00000206103.2 Il21r ENSMUST00000206103.2 Membrane ; Single- pass type I membrane protein (from UniProt Q6PEU8) AF279436 ENSMUST00000206103.1 Il21r Q6PEU8 Q6PEU8_MOUSE uc009jqf.1 uc009jqf.2 uc009jqf.3 uc009jqf.4 Membrane ; Single- pass type I membrane protein cytokine receptor activity membrane cytokine-mediated signaling pathway uc009jqf.1 uc009jqf.2 uc009jqf.3 uc009jqf.4 
ENSMUST00000206112.2 Gm45053 ENSMUST00000206112.2 Gm45053 (from geneSymbol) AK045661 ENSMUST00000206112.1 uc291fvo.1 uc291fvo.2 uc291fvo.1 uc291fvo.2 
ENSMUST00000206114.3 Or1a1 ENSMUST00000206114.3 Membrane ; Multi- pass membrane protein (from UniProt Q7TRX2) ENSMUST00000206114.1 ENSMUST00000206114.2 Olfr403 Olfr43 Or1a1 Q7TRX2 Q7TRX2_MOUSE uc288abh.1 uc288abh.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288abh.1 uc288abh.2 
ENSMUST00000206120.2 Gm44769 ENSMUST00000206120.2 Gm44769 (from geneSymbol) ENSMUST00000206120.1 LF195555 uc291frp.1 uc291frp.2 uc291frp.1 uc291frp.2 
ENSMUST00000206124.2 Prss8 ENSMUST00000206124.2 serine protease 8 (prostasin), transcript variant 2 (from RefSeq NM_001407961.1) ENSMUST00000206124.1 NM_001407961 Prss8 Q99L44 Q99L44_MOUSE uc291vzh.1 uc291vzh.2 serine-type endopeptidase activity plasma membrane proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc291vzh.1 uc291vzh.2 
ENSMUST00000206129.3 Pnma8c ENSMUST00000206129.3 PNMA family member 8C (from RefSeq NM_001370851.1) A0A1B0GT27 A0A1B0GT27_MOUSE ENSMUST00000206129.1 ENSMUST00000206129.2 Gm42372 NM_001370851 Pnma8c uc291mdh.1 uc291mdh.2 Belongs to the PNMA family. uc291mdh.1 uc291mdh.2 
ENSMUST00000206130.2 Gm44636 ENSMUST00000206130.2 Gm44636 (from geneSymbol) ENSMUST00000206130.1 uc291omm.1 uc291omm.2 uc291omm.1 uc291omm.2 
ENSMUST00000206146.2 4833421K07Rik ENSMUST00000206146.2 4833421K07Rik (from geneSymbol) AK014746 ENSMUST00000206146.1 uc291qjc.1 uc291qjc.2 uc291qjc.1 uc291qjc.2 
ENSMUST00000206152.2 4930517G19Rik ENSMUST00000206152.2 4930517G19Rik (from geneSymbol) AK015812 ENSMUST00000206152.1 uc291hdu.1 uc291hdu.2 uc291hdu.1 uc291hdu.2 
ENSMUST00000206155.4 Snhg1 ENSMUST00000206155.4 Snhg1 (from geneSymbol) AK036616 ENSMUST00000206155.1 ENSMUST00000206155.2 ENSMUST00000206155.3 uc008gmj.1 uc008gmj.2 uc008gmj.3 uc008gmj.4 uc008gmj.5 uc008gmj.6 uc008gmj.1 uc008gmj.2 uc008gmj.3 uc008gmj.4 uc008gmj.5 uc008gmj.6 
ENSMUST00000206158.3 Siglecl1 ENSMUST00000206158.3 Siglecl1 (from geneSymbol) BC100510 ENSMUST00000206158.1 ENSMUST00000206158.2 uc009gmx.1 uc009gmx.2 uc009gmx.3 uc009gmx.4 uc009gmx.1 uc009gmx.2 uc009gmx.3 uc009gmx.4 
ENSMUST00000206159.2 Gm44674 ENSMUST00000206159.2 Gm44674 (from geneSymbol) ENSMUST00000206159.1 uc291wdk.1 uc291wdk.2 uc291wdk.1 uc291wdk.2 
ENSMUST00000206172.2 Gm44756 ENSMUST00000206172.2 Gm44756 (from geneSymbol) AK089445 ENSMUST00000206172.1 uc291pbq.1 uc291pbq.2 uc291pbq.1 uc291pbq.2 
ENSMUST00000206181.2 Psg-ps1 ENSMUST00000206181.2 pregnancy specific beta-1-glycoprotein, pseudogene 1 (from RefSeq NR_002857.1) ENSMUST00000206181.1 NR_002857 uc009fiy.1 uc009fiy.2 uc009fiy.3 uc009fiy.1 uc009fiy.2 uc009fiy.3 
ENSMUST00000206185.2 Gm44750 ENSMUST00000206185.2 Gm44750 (from geneSymbol) AK053347 ENSMUST00000206185.1 uc291ght.1 uc291ght.2 uc291ght.1 uc291ght.2 
ENSMUST00000206187.2 Gm44897 ENSMUST00000206187.2 Gm44897 (from geneSymbol) AK052970 ENSMUST00000206187.1 uc291qiz.1 uc291qiz.2 uc291qiz.1 uc291qiz.2 
ENSMUST00000206188.2 Gm34121 ENSMUST00000206188.2 predicted gene, 34121, transcript variant 2 (from RefSeq NR_166588.1) ENSMUST00000206188.1 NR_166588 uc291qkr.1 uc291qkr.2 uc291qkr.1 uc291qkr.2 
ENSMUST00000206189.2 Gm39091 ENSMUST00000206189.2 Gm39091 (from geneSymbol) AK080247 ENSMUST00000206189.1 uc009jyg.1 uc009jyg.2 uc009jyg.3 uc009jyg.1 uc009jyg.2 uc009jyg.3 
ENSMUST00000206190.2 Gm44896 ENSMUST00000206190.2 Gm44896 (from geneSymbol) ENSMUST00000206190.1 uc291qja.1 uc291qja.2 uc291qja.1 uc291qja.2 
ENSMUST00000206197.2 Gm44735 ENSMUST00000206197.2 Gm44735 (from geneSymbol) ENSMUST00000206197.1 uc291vqm.1 uc291vqm.2 uc291vqm.1 uc291vqm.2 
ENSMUST00000206202.2 Gm44985 ENSMUST00000206202.2 Gm44985 (from geneSymbol) AK038907 ENSMUST00000206202.1 uc291veb.1 uc291veb.2 uc291veb.1 uc291veb.2 
ENSMUST00000206205.3 Or5k1 ENSMUST00000206205.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9QAT7) A0A0U1RPE3 E9QAT7 E9QAT7_MOUSE ENSMUST00000206205.1 ENSMUST00000206205.2 Olfr173 Or5k1 uc289fff.1 uc289fff.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289fff.1 uc289fff.2 
ENSMUST00000206208.2 Gm45211 ENSMUST00000206208.2 Gm45211 (from geneSymbol) ENSMUST00000206208.1 uc291rno.1 uc291rno.2 uc291rno.1 uc291rno.2 
ENSMUST00000206215.2 ENSMUSG00000121675 ENSMUST00000206215.2 ENSMUSG00000121675 (from geneSymbol) ENSMUST00000206215.1 uc291ggd.1 uc291ggd.2 uc291ggd.1 uc291ggd.2 
ENSMUST00000206216.2 Gm15533 ENSMUST00000206216.2 Gm15533 (from geneSymbol) ENSMUST00000206216.1 uc291wac.1 uc291wac.2 uc291wac.1 uc291wac.2 
ENSMUST00000206225.2 Gm44940 ENSMUST00000206225.2 Gm44940 (from geneSymbol) AK138912 ENSMUST00000206225.1 uc291vso.1 uc291vso.2 uc291vso.1 uc291vso.2 
ENSMUST00000206244.3 4933432K03Rik ENSMUST00000206244.3 4933432K03Rik (from geneSymbol) AK017025 ENSMUST00000206244.1 ENSMUST00000206244.2 uc291vcm.1 uc291vcm.2 uc291vcm.3 uc291vcm.1 uc291vcm.2 uc291vcm.3 
ENSMUST00000206250.2 Gm44712 ENSMUST00000206250.2 Gm44712 (from geneSymbol) ENSMUST00000206250.1 uc291heh.1 uc291heh.2 uc291heh.1 uc291heh.2 
ENSMUST00000206277.2 Trpm1 ENSMUST00000206277.2 Membrane ; Multi- pass membrane protein (from UniProt A0A0U1RQ32) A0A0U1RQ32 A0A0U1RQ32_MOUSE AY180104 ENSMUST00000206277.1 Trpm1 uc291qyf.1 uc291qyf.2 Membrane ; Multi- pass membrane protein ion channel activity cation channel activity ion transport G-protein coupled glutamate receptor signaling pathway membrane integral component of membrane ion transmembrane transport protein tetramerization transmembrane transport cellular response to light stimulus cation transmembrane transport uc291qyf.1 uc291qyf.2 
ENSMUST00000206278.2 Gm44506 ENSMUST00000206278.2 Gm44506 (from geneSymbol) AF061531 ENSMUST00000206278.1 uc057cab.1 uc057cab.2 uc057cab.3 uc057cab.4 uc057cab.1 uc057cab.2 uc057cab.3 uc057cab.4 
ENSMUST00000206280.2 Or3a10 ENSMUST00000206280.2 Odorant receptor. (from UniProt Q60891) ENSMUST00000206280.1 Mor255-2 O3A10_MOUSE Olfr1 Olfr139 Or3a10 Q60891 Q8VGR1 Q9EPY8 uc288aaw.1 uc288aaw.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288aaw.1 uc288aaw.2 
ENSMUST00000206281.2 Gm45081 ENSMUST00000206281.2 Gm45081 (from geneSymbol) AK080637 ENSMUST00000206281.1 uc291rbd.1 uc291rbd.2 uc291rbd.1 uc291rbd.2 
ENSMUST00000206285.2 Gm44749 ENSMUST00000206285.2 Gm44749 (from geneSymbol) AK157295 ENSMUST00000206285.1 uc291vew.1 uc291vew.2 uc291vew.1 uc291vew.2 
ENSMUST00000206288.2 Gm44510 ENSMUST00000206288.2 Gm44510 (from geneSymbol) ENSMUST00000206288.1 uc291qkp.1 uc291qkp.2 uc291qkp.1 uc291qkp.2 
ENSMUST00000206290.2 4833404L02Rik ENSMUST00000206290.2 4833404L02Rik (from geneSymbol) AK014654 ENSMUST00000206290.1 uc057bzc.1 uc057bzc.2 uc057bzc.3 uc057bzc.1 uc057bzc.2 uc057bzc.3 
ENSMUST00000206292.2 Gm44986 ENSMUST00000206292.2 Gm44986 (from geneSymbol) AK140617 ENSMUST00000206292.1 uc291vdo.1 uc291vdo.2 uc291vdo.1 uc291vdo.2 
ENSMUST00000206293.2 Gm44707 ENSMUST00000206293.2 Gm44707 (from geneSymbol) ENSMUST00000206293.1 uc291pbl.1 uc291pbl.2 uc291pbl.1 uc291pbl.2 
ENSMUST00000206297.2 Gm45204 ENSMUST00000206297.2 Gm45204 (from geneSymbol) AK044159 ENSMUST00000206297.1 uc291vyg.1 uc291vyg.2 uc291vyg.1 uc291vyg.2 
ENSMUST00000206304.3 Mypopos ENSMUST00000206304.3 Mypopos (from geneSymbol) ENSMUST00000206304.1 ENSMUST00000206304.2 uc291mgs.1 uc291mgs.2 uc291mgs.3 uc291mgs.1 uc291mgs.2 uc291mgs.3 
ENSMUST00000206305.2 Fxyd1 ENSMUST00000206305.2 FXYD domain-containing ion transport regulator 1, transcript variant 1 (from RefSeq NM_019503.4) ENSMUST00000206305.1 Fxyd1 NM_019503 PLM_MOUSE Plm Q9Z239 uc291ocw.1 uc291ocw.2 This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]. Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:15563542, PubMed:18065526). Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (By similarity). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation- mediated inhibition of ATP1B1 (PubMed:21454534). Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone (PubMed:19187398). Homotetramer (By similarity). Monomer (By similarity). Regulatory subunit of the sodium/potassium-transporting ATPase (NKA) which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and an additional regulatory subunit (By similarity). The monomeric form associates with NKA while the oligomeric form does not (PubMed:23532852). Interacts with the catalytic alpha-1 subunit ATP1A1 (PubMed:17283221). Also interacts with the catalytic alpha-2 and alpha- 3 subunits ATP1A2 and ATP1A3 (By similarity). Very little interaction with the catalytic alpha subunits ATP1A1, ATP1A2 or ATP1A3 when phosphorylated at Ser-83 (By similarity). Interacts with the non- catalytic beta-1 subunit ATP1B1 (By similarity). Oxidative stress decreases interaction with ATP1A1 but increases interaction with ATP1B1 (By similarity). Cell membrane, sarcolemma ; Single-pass type I membrane protein Apical cell membrane ; Single-pass type I membrane protein Membrane, caveola Cell membrane, sarcolemma, T-tubule Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks. The cytoplasmic domain is sufficient to regulate sodium/potassium-transporting ATPase activity. Major plasma membrane substrate for cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation. Phosphorylation at Ser-88 stimulates sodium/potassium-transporting ATPase activity while the unphosphorylated form inhibits sodium/potassium-transporting ATPase activity. Phosphorylation increases tetramerization, decreases binding to ATP1A1 and reduces inhibition of ATP1A1 activity. Phosphorylation at Ser-83 leads to greatly reduced interaction with ATP1A1, ATP1A2 and ATP1A3. May be phosphorylated by DMPK. Palmitoylation increases half-life and stability and is enhanced upon phosphorylation at Ser-88 by PKA. Adults exhibit increased cardiac mass, larger cardiomyocytes, higher ejection fractions (the amount of blood pumped out of the ventricles with each contraction) and reduced sodium/potassium-transporting ATPase (NKA) activity in a mixed strain background of C57BL/6 and 129/SvJ (PubMed:15563542). Decreased cardiac contractile function and increased NKA activity in a congenic C57BL/6 background (PubMed:18065526). Increased glutathionylation of the NKA beta subunit ATP1B1 (PubMed:21454534). Decreased excitability of neurons which secrete gonadotropin-releasing hormone and delayed female puberty (PubMed:19187398). Belongs to the FXYD family. plasma membrane sodium:potassium-exchanging ATPase complex caveola ion transport potassium ion transport sodium ion transport negative regulation of protein glutathionylation intercalated disc membrane integral component of membrane apical plasma membrane myosin binding sodium channel regulator activity T-tubule positive regulation of organic acid transport sarcolemma regulation of ion transport ion channel binding ATPase binding regulation of cytosolic calcium ion concentration regulation of cardiac muscle cell contraction regulation of cardiac muscle cell membrane potential ion channel regulator activity positive regulation of sodium ion export from cell positive regulation of inorganic anion transmembrane transport regulation of sodium ion transmembrane transporter activity uc291ocw.1 uc291ocw.2 
ENSMUST00000206316.2 Gm44553 ENSMUST00000206316.2 Gm44553 (from geneSymbol) ENSMUST00000206316.1 LF196371 uc291rkb.1 uc291rkb.2 uc291rkb.1 uc291rkb.2 
ENSMUST00000206318.3 Gm44970 ENSMUST00000206318.3 Gm44970 (from geneSymbol) ENSMUST00000206318.1 ENSMUST00000206318.2 uc291mxa.1 uc291mxa.2 uc291mxa.3 uc291mxa.1 uc291mxa.2 uc291mxa.3 
ENSMUST00000206324.3 Or14p1 ENSMUST00000206324.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A0U1RPZ4) A0A0U1RPZ4 A0A0U1RPZ4_MOUSE ENSMUST00000206324.1 ENSMUST00000206324.2 Olfr465 Or14p1 uc288nxn.1 uc288nxn.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288nxn.1 uc288nxn.2 
ENSMUST00000206325.2 Cd19 ENSMUST00000206325.2 CD19 antigen, transcript variant 1 (from RefSeq NM_009844.3) CD19_MOUSE ENSMUST00000206325.1 NM_009844 P25918 Q542B2 uc009jrc.1 uc009jrc.2 uc009jrc.3 Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:9382888, PubMed:12387743, PubMed:20101619). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:7542548, PubMed:7543183, PubMed:9317126). Required for normal differentiation of B-1 cells (PubMed:7542548, PubMed:7543183, PubMed:12387743). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:7542548, PubMed:9317126, PubMed:12387743). Required for normal levels of serum immunoglobulins, and for production of high- affinity antibodies in response to antigen challenge (PubMed:7542548, PubMed:7543183, PubMed:12387743). Interacts with CR2/CD21. Part of a complex composed of CD19, CR2/CD21, CD81 and IFITM1/CD225 in the membrane of mature B-cells. Interacts directly with CD81 (via the second extracellular domain); this interaction is initiated early during biosynthesis in the ER/pre- Golgi compartments and is essential for trafficking and compartmentalization of CD19 receptor on the cell surface of when phosphorylated on Tyr-346 and/or Tyr-376. Interacts with PLCG2 when phosphorylated on Tyr-402. Interacts with LYN. Interacts (when tyrosine phosphorylated) with the regulatory p85 subunit of phosphatidylinositol 3-kinase (PIK3R1 or PIK3R2). Cell membrane ingle-pass type I membrane protein Membrane raft ; Single-pass type I membrane protein Detected on B cells in spleen, bone marrow, thymus and lymph nodes (PubMed:12387743, PubMed:7542548, PubMed:20101619). Detected on peripheral blood lymphocytes (at protein level) (PubMed:7543183). Phosphorylated on tyrosine following B-cell activation (PubMed:20101619). Phosphorylated on tyrosine residues by LYN (By similarity). Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-522 is extremely rapid, followed by phosphorylation at Tyr-402. In contrast, phosphorylation of Tyr-493 appears more slowly and is more transient, returning rapidly to basal levels (PubMed:20101619). Mutant mice are born at the expected Mendelian ratio, thrive and are fertile (PubMed:7542548). Mutant mice display normal differentiation and expansion of pro-B cells, pre-B cells, immature B cells and resting mature B cells in bone marrow (PubMed:7542548, PubMed:7543183, PubMed:9317126). Number and surface phenotype of conventional B cells in spleen, Peyer's patch and lymph nodes appear normal (PubMed:7543183). In contrast, the numbers of B-1 cells are decreased to 10-20% of the normal values in the peritoneal cavity, together with a severe reduction of serum IgM levels (PubMed:7542548, PubMed:7543183, PubMed:12387743). Likewise, mutant mice display severely reduced serum IgG1 and IgE levels (PubMed:7543183). Mutant mice display severely reduced B cell responses to antigens, with a strong decrease in the production of serum antibodies after an antigenic challenge, and defective production of high-affinity antibodies (PubMed:7543183). B-1 B cell differentiation adaptive immune response B cell proliferation involved in immune response immune system process protein binding plasma membrane integral component of plasma membrane external side of plasma membrane membrane integral component of membrane immunoglobulin mediated immune response B cell mediated immunity macromolecular complex positive regulation of phosphatidylinositol 3-kinase activity membrane raft antigen receptor-mediated signaling pathway B cell receptor signaling pathway regulation of B cell receptor signaling pathway regulation of B cell activation positive regulation of release of sequestered calcium ion into cytosol uc009jrc.1 uc009jrc.2 uc009jrc.3 
ENSMUST00000206341.2 Fxyd7 ENSMUST00000206341.2 Belongs to the FXYD family. (from UniProt A0A0U1RPY2) A0A0U1RPY2 A0A0U1RPY2_MOUSE BC061101 ENSMUST00000206341.1 Fxyd7 uc291ocr.1 uc291ocr.2 Belongs to the FXYD family. ion transport membrane integral component of membrane regulation of ion transport ion channel regulator activity uc291ocr.1 uc291ocr.2 
ENSMUST00000206354.2 Gm45184 ENSMUST00000206354.2 Gm45184 (from geneSymbol) ENSMUST00000206354.1 uc291vuo.1 uc291vuo.2 uc291vuo.1 uc291vuo.2 
ENSMUST00000206365.3 Or7a40 ENSMUST00000206365.3 Odorant receptor. (from UniProt Q9JHB2) ENSMUST00000206365.1 ENSMUST00000206365.2 Mor140-1 O7A40_MOUSE Olfr19 Or7a40 Q9JHB2 Q9JM32 uc007yiz.1 uc007yiz.2 uc007yiz.3 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007yiz.1 uc007yiz.2 uc007yiz.3 
ENSMUST00000206367.2 2200007N16Rik ENSMUST00000206367.2 2200007N16Rik (from geneSymbol) AK019048 ENSMUST00000206367.1 uc291mvl.1 uc291mvl.2 uc291mvl.1 uc291mvl.2 
ENSMUST00000206372.2 Gm36546 ENSMUST00000206372.2 Gm36546 (from geneSymbol) ENSMUST00000206372.1 uc291pav.1 uc291pav.2 uc291pav.1 uc291pav.2 
ENSMUST00000206373.2 Gm44757 ENSMUST00000206373.2 Gm44757 (from geneSymbol) ENSMUST00000206373.1 uc291pec.1 uc291pec.2 uc291pec.1 uc291pec.2 
ENSMUST00000206375.2 Gm44760 ENSMUST00000206375.2 Gm44760 (from geneSymbol) AK084819 ENSMUST00000206375.1 uc291vwv.1 uc291vwv.2 uc291vwv.1 uc291vwv.2 
ENSMUST00000206384.2 Gm45203 ENSMUST00000206384.2 Gm45203 (from geneSymbol) AK030590 ENSMUST00000206384.1 uc291rsz.1 uc291rsz.2 uc291rsz.1 uc291rsz.2 
ENSMUST00000206387.2 Gm44974 ENSMUST00000206387.2 Gm44974 (from geneSymbol) ENSMUST00000206387.1 uc291rsh.1 uc291rsh.2 uc291rsh.1 uc291rsh.2 
ENSMUST00000206389.2 Aqp11 ENSMUST00000206389.2 aquaporin 11 (from RefSeq NM_175105.3) AQP11_MOUSE Aqp11 ENSMUST00000206389.1 NM_175105 Q8BHH1 Q8JZU1 uc009ijs.1 uc009ijs.2 uc009ijs.3 Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:21118806, PubMed:21251984). In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:23275615, PubMed:30656220). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (PubMed:24854278, PubMed:18606867). Plays a role in the proximal tubule function by regulating its endosomal acidification (PubMed:16107722). May play a role in postnatal kidney development (PubMed:18701606, PubMed:23486012, PubMed:27582095). Homodimer; disulfide-linked (PubMed:16107722, PubMed:21118806). Can also form homomultimer (PubMed:21118806). Cytoplasmic vesicle membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ulti-pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasm Cytoplasm, perinuclear region Note=Localizes mainly to the periphery of lipid droplets. it accumulates partly in mitochondrial-associated endoplasmic reticulum membranes. Highly expressed in the S1 proximal tubule segment, (PubMed:23486012). Expressed in the testis, kidney, and liver. Weakly expressed in the heart, brain, and muscle. Highly expressed in the testis. Expressed in the proximal tubule of the cortex of 8-day-old mouse kidney (PubMed:16107722). Expressed in retina specifically at retinal Mueller glial cells (PubMed:27107718). Expressed in brain. Expressed abundantly at the choroid plexus but also expressed weakly in the parenchyma. Expressed at the capillary endothelium in the cerebral white matter (PubMed:27258268). Expressed in adult testis, in the elongated spermatids (ES) and in residual bodies inside Sertoli cells (PubMed:19812234). Mainly expressed at the brain surface with a slight expression in the brain parenchyma at postnatal day 1, 7, and 14. At the stage of postnatal day 28, mainly expressed in the parenchyma. Increased by glucose (PubMed:23486012). Decreased by phlorizin (PubMed:23486012). The NPC motif is essential for oligomerization and water permeability function. Not glycosylated. Homozygous Aqp11 knockout mice are born normally at the expected Mendelian frequency and are normal. However, after 15 days mice begin dying, and only 15% survive until day 60. Mice exhibit severe renal dysfunction with a significant increase of blood urea nitrogen (BUN) level. The kidneys are large and pale with rough texture occupying the whole abdominal cavity. The kidneys are anemic and polycystic following swelling and vacuolization of the proximal tubule (PubMed:18701606, PubMed:16107722). Mice with conditional knockout of Aqp11 in liver appear to have a normal life span of more than 1 year, are fertile (both females and males), show a normal growth rate, and do not show any behavioral abnormalities. Unchallenged mice have normal longevity, their livers appear normal, and reveal only a minor defect in lipid handling. In contrast, rough endoplasmic reticulum (RER)- derived vacuoles develop rapidly in the periportal hepatocytes of liver-specific following 24 hours of fasting and refeeding (PubMed:23275615). Mice with temporal conditional knockout of Aqp11 between post natal days (P) P2 and P12 exhibit apparently normal kidneys at birth and within the first two postnatal weeks of life exhibit tubular dilations. When conditional knockout of Aqp11 is induced until P8, proximal tubule (PT) cell vacuolization and apparent tubular cysts are formed, whereas no deficient renal development are observed if conditional knockout of Aqp11 starts at P12 (PubMed:27582095). Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily. Sequence=AAH37088.1; Type=Erroneous initiation; Evidence=; kidney development cytoplasm endoplasmic reticulum cytosol water transport cell surface water channel activity channel activity membrane integral component of membrane dendrite endosomal lumen acidification protein homooligomerization transmembrane transport proximal tubule development plasma membrane uc009ijs.1 uc009ijs.2 uc009ijs.3 
ENSMUST00000206393.2 Gm44738 ENSMUST00000206393.2 Gm44738 (from geneSymbol) ENSMUST00000206393.1 uc291rla.1 uc291rla.2 uc291rla.1 uc291rla.2 
ENSMUST00000206401.2 Gm45210 ENSMUST00000206401.2 Gm45210 (from geneSymbol) ENSMUST00000206401.1 uc291rnr.1 uc291rnr.2 uc291rnr.1 uc291rnr.2 
ENSMUST00000206403.2 Gm44950 ENSMUST00000206403.2 Gm44950 (from geneSymbol) ENSMUST00000206403.1 LF196392 uc291rsn.1 uc291rsn.2 uc291rsn.1 uc291rsn.2 
ENSMUST00000206404.2 Gm44719 ENSMUST00000206404.2 Gm44719 (from geneSymbol) ENSMUST00000206404.1 uc291qyp.1 uc291qyp.2 uc291qyp.1 uc291qyp.2 
ENSMUST00000206410.3 Or2m13 ENSMUST00000206410.3 olfactory receptor family 2 subfamily M member 13 (from RefSeq NM_146466.1) A0A0U1RPS5 ENSMUST00000206410.1 ENSMUST00000206410.2 NM_146466 Olfr165 Or2m13 Q8VFA2 Q8VFA2_MOUSE uc289dhh.1 uc289dhh.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289dhh.1 uc289dhh.2 
ENSMUST00000206417.2 Gm44616 ENSMUST00000206417.2 Gm44616 (from geneSymbol) AK054536 ENSMUST00000206417.1 uc291qkc.1 uc291qkc.2 uc291qkc.1 uc291qkc.2 
ENSMUST00000206420.2 Gm45008 ENSMUST00000206420.2 Gm45008 (from geneSymbol) ENSMUST00000206420.1 uc291oub.1 uc291oub.2 uc291oub.1 uc291oub.2 
ENSMUST00000206422.2 Phldb3 ENSMUST00000206422.2 Phldb3 (from geneSymbol) BC052555 E9QAF4 E9QAF4_MOUSE ENSMUST00000206422.1 Phldb3 uc009fqc.1 uc009fqc.2 uc009fqc.3 cellular_component biological_process enzyme binding uc009fqc.1 uc009fqc.2 uc009fqc.3 
ENSMUST00000206423.2 Gm44949 ENSMUST00000206423.2 Gm44949 (from geneSymbol) AK140515 ENSMUST00000206423.1 uc291rss.1 uc291rss.2 uc291rss.1 uc291rss.2 
ENSMUST00000206435.2 Gucy2d ENSMUST00000206435.2 guanylate cyclase 2d (from RefSeq NM_001130693.3) A0A0U1RPR8 ENSMUST00000206435.1 GUC2D_MOUSE Gucy2d NM_001130693 uc033jal.1 uc033jal.2 uc033jal.3 Functions as an olfactory receptor activated by urine odorants, uroguanylin and guanylin and as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2) (PubMed:17724338, PubMed:17702944, PubMed:20637621). Has guanylate cyclase activity upon binding of the ligand (By similarity). Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency (PubMed:17724338, PubMed:20637621). Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference (PubMed:20637621). Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2; Evidence=; Activated by Ca(2+). Interacts (via the catalytic domain) with NCALD. Cell projection, cilium membrane ; Single-pass type I membrane protein. Found in a subset of olfactory neurons in the main olfactory epithelium. The protein kinase domain is predicted to be catalytically inactive. Deficient mice lack olfactory response to uroguanylin and guanylin. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. The gene names for receptor guanylyl cyclases are inconsistent between mouse and human. The ortholog of the mouse Gucy2d gene is a pseudogene in humans. The mouse Gucy2d is not an ortholog of the human GUCY2D gene, the latter of which encodes a retinal receptor guanylyl cyclase involved in phototransduction. nucleotide binding peptide receptor activity guanylate cyclase activity protein kinase activity ATP binding plasma membrane cGMP biosynthetic process protein phosphorylation signal transduction receptor guanylyl cyclase signaling pathway cyclic nucleotide biosynthetic process membrane integral component of membrane lyase activity phosphorus-oxygen lyase activity natriuretic peptide receptor activity peptide hormone binding intracellular signal transduction uc033jal.1 uc033jal.2 uc033jal.3 
ENSMUST00000206447.2 Gm44778 ENSMUST00000206447.2 Gm44778 (from geneSymbol) ENSMUST00000206447.1 uc291wek.1 uc291wek.2 uc291wek.1 uc291wek.2 
ENSMUST00000206449.2 Gm44951 ENSMUST00000206449.2 Gm44951 (from geneSymbol) ENSMUST00000206449.1 uc291rsq.1 uc291rsq.2 uc291rsq.1 uc291rsq.2 
ENSMUST00000206455.2 Chrna2 ENSMUST00000206455.2 cholinergic receptor nicotinic alpha 2 subunit, transcript variant 2 (from RefSeq NM_001425568.1) ACHA2_MOUSE ENSMUST00000206455.1 NM_001425568 Q91X60 uc288vgj.1 uc288vgj.2 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. The alpha- 2:beta-2 nAChR complex is proposed to be a heteropentamer with two subtypes: LS (low agonist sensitivity) with a (alpha-2)3:(beta-2)2 and HS (high agonist sensitivity) with a (alpha-2)2:(beta-2)3 stoichiometry; the subtypes differ in their subunit binding interfaces which are involved in ligand binding (By similarity). Postsynaptic cell membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub- subfamily. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane integral component of plasma membrane acetylcholine-gated channel complex ion transport signal transduction chemical synaptic transmission synaptic transmission, cholinergic neuromuscular synaptic transmission drug binding acetylcholine receptor activity membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction ion transmembrane transport response to nicotine acetylcholine binding regulation of membrane potential neuron projection synapse postsynaptic membrane neurological system process protein heterooligomerization regulation of postsynaptic membrane potential excitatory postsynaptic potential cell periphery uc288vgj.1 uc288vgj.2 
ENSMUST00000206459.2 Gm45149 ENSMUST00000206459.2 Gm45149 (from geneSymbol) AK089683 ENSMUST00000206459.1 uc291mek.1 uc291mek.2 uc291mek.1 uc291mek.2 
ENSMUST00000206463.3 Or5h18 ENSMUST00000206463.3 Potential odorant receptor. (from UniProt Q8VEX5) ENSMUST00000206463.1 ENSMUST00000206463.2 Mor183-9 O5H18_MOUSE Olfr186 Or5h18 Q8VEX5 uc289ffv.1 uc289ffv.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ffv.1 uc289ffv.2 
ENSMUST00000206473.2 Gm44722 ENSMUST00000206473.2 Gm44722 (from geneSymbol) ENSMUST00000206473.1 uc291qyl.1 uc291qyl.2 uc291qyl.1 uc291qyl.2 
ENSMUST00000206485.2 Gm44877 ENSMUST00000206485.2 Gm44877 (from geneSymbol) ENSMUST00000206485.1 uc291kvg.1 uc291kvg.2 uc291kvg.1 uc291kvg.2 
ENSMUST00000206490.2 Gm5592 ENSMUST00000206490.2 Gm5592 (from geneSymbol) B2RW58 BC147594 CB078_MOUSE ENSMUST00000206490.1 Q3V0A6 uc291ouv.1 uc291ouv.2 molecular_function cellular_component biological_process uc291ouv.1 uc291ouv.2 
ENSMUST00000206502.2 Gm45141 ENSMUST00000206502.2 Gm45141 (from geneSymbol) AK077216 ENSMUST00000206502.1 uc291vjs.1 uc291vjs.2 uc291vjs.1 uc291vjs.2 
ENSMUST00000206503.2 Gm44920 ENSMUST00000206503.2 Gm44920 (from geneSymbol) ENSMUST00000206503.1 uc291koh.1 uc291koh.2 uc291koh.1 uc291koh.2 
ENSMUST00000206512.2 2610306O10Rik ENSMUST00000206512.2 2610306O10Rik (from geneSymbol) AK012000 ENSMUST00000206512.1 uc291wcv.1 uc291wcv.2 uc291wcv.1 uc291wcv.2 
ENSMUST00000206516.2 9430064I24Rik ENSMUST00000206516.2 9430064I24Rik (from geneSymbol) ENSMUST00000206516.1 S82156 uc291vxs.1 uc291vxs.2 uc291vxs.1 uc291vxs.2 
ENSMUST00000206517.2 Tm2d3 ENSMUST00000206517.2 TM2 domain containing 3, transcript variant 5 (from RefSeq NM_001403394.1) A0A0U1RNE7 A0A0U1RNE7_MOUSE ENSMUST00000206517.1 NM_001403394 Tm2d3 uc291raj.1 uc291raj.2 Membrane ; Multi- pass membrane protein Belongs to the TM2 family. membrane integral component of membrane uc291raj.1 uc291raj.2 
ENSMUST00000206520.3 Or4e1 ENSMUST00000206520.3 olfactory receptor family 4 subfamily E member 1 (from RefSeq NM_020513.3) ENSMUST00000206520.1 ENSMUST00000206520.2 MOR10 NM_020513 Olfr1508 Or4e1 Q9R0K4 Q9R0K4_MOUSE uc033gqk.1 uc033gqk.2 uc033gqk.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB174090.1, CB174538.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033gqk.1 uc033gqk.2 uc033gqk.3 
ENSMUST00000206521.3 Gm21269 ENSMUST00000206521.3 Gm21269 (from geneSymbol) ENSMUST00000206521.1 ENSMUST00000206521.2 uc009hwb.1 uc009hwb.2 uc009hwb.3 uc009hwb.4 uc009hwb.5 uc009hwb.1 uc009hwb.2 uc009hwb.3 uc009hwb.4 uc009hwb.5 
ENSMUST00000206525.2 Gm45054 ENSMUST00000206525.2 Gm45054 (from geneSymbol) ENSMUST00000206525.1 uc291qyc.1 uc291qyc.2 uc291qyc.1 uc291qyc.2 
ENSMUST00000206533.2 4732496C06Rik ENSMUST00000206533.2 RIKEN cDNA 4732496C06 gene (from RefSeq NR_190053.1) ENSMUST00000206533.1 NR_190053 uc291utu.1 uc291utu.2 uc291utu.1 uc291utu.2 
ENSMUST00000206543.2 Gm45139 ENSMUST00000206543.2 Gm45139 (from geneSymbol) AK081795 ENSMUST00000206543.1 uc291rnn.1 uc291rnn.2 uc291rnn.1 uc291rnn.2 
ENSMUST00000206547.2 Zfp114 ENSMUST00000206547.2 zinc finger protein 114, transcript variant 2 (from RefSeq NM_001404000.1) ENSMUST00000206547.1 NM_001404000 Q3UTF4 Q3UTF4_MOUSE Zfp114 uc009foy.1 uc009foy.2 uc009foy.3 Nucleus nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc009foy.1 uc009foy.2 uc009foy.3 
ENSMUST00000206550.2 Gm44794 ENSMUST00000206550.2 Gm44794 (from geneSymbol) ENSMUST00000206550.1 uc291qzy.1 uc291qzy.2 uc291qzy.1 uc291qzy.2 
ENSMUST00000206555.2 BC026762 ENSMUST00000206555.2 BC026762 (from geneSymbol) ENSMUST00000206555.1 uc291nbq.1 uc291nbq.2 uc291nbq.1 uc291nbq.2 
ENSMUST00000206557.3 Gm32633 ENSMUST00000206557.3 predicted gene, 32633, transcript variant 1 (from RefSeq NR_169109.1) ENSMUST00000206557.1 ENSMUST00000206557.2 NR_169109 uc291qyb.1 uc291qyb.2 uc291qyb.3 uc291qyb.1 uc291qyb.2 uc291qyb.3 
ENSMUST00000206561.2 Exosc5 ENSMUST00000206561.2 Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity). In vitro, EXOSC5 does not bind or digest single-stranded RNA and binds to double-stranded DNA without detectable DNase activity (By similarity). (from UniProt Q9CRA8) AK137780 D7Wsu180e ENSMUST00000206561.1 EXOS5_MOUSE Q8K1J2 Q9CRA8 Rrp46 uc291mzz.1 uc291mzz.2 Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity). In vitro, EXOSC5 does not bind or digest single-stranded RNA and binds to double-stranded DNA without detectable DNase activity (By similarity). Homodimer. Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain- containing subunits specifically containing the heterodimers EXOSC4- EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain- containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with EXOSC1. Interacts with GTPBP1. Interacts with ZC3HAV1. Interacts with DDX17 only in the presence of ZC3HAV1 in an RNA-independent manner. Nucleus, nucleolus Cytoplasm Nucleus Belongs to the RNase PH family. nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) molecular_function RNA binding nucleus nucleolus cytoplasm rRNA processing RNA catabolic process rRNA catabolic process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U4 snRNA 3'-end processing transcriptionally active chromatin exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay DNA deamination defense response to virus nuclear mRNA surveillance polyadenylation-dependent snoRNA 3'-end processing uc291mzz.1 uc291mzz.2 
ENSMUST00000206563.2 Gm44745 ENSMUST00000206563.2 Gm44745 (from geneSymbol) ENSMUST00000206563.1 uc291veo.1 uc291veo.2 uc291veo.1 uc291veo.2 
ENSMUST00000206564.2 Gm30146 ENSMUST00000206564.2 Gm30146 (from geneSymbol) AK082843 ENSMUST00000206564.1 uc291nbi.1 uc291nbi.2 uc291nbi.1 uc291nbi.2 
ENSMUST00000206576.2 Gm45217 ENSMUST00000206576.2 Gm45217 (from geneSymbol) AK040789 ENSMUST00000206576.1 uc291hdo.1 uc291hdo.2 uc291hdo.1 uc291hdo.2 
ENSMUST00000206579.2 Gm32647 ENSMUST00000206579.2 Gm32647 (from geneSymbol) AK077481 ENSMUST00000206579.1 uc009iin.1 uc009iin.2 uc009iin.3 uc009iin.1 uc009iin.2 uc009iin.3 
ENSMUST00000206586.2 Gm44874 ENSMUST00000206586.2 Gm44874 (from geneSymbol) AK084155 ENSMUST00000206586.1 uc291vhy.1 uc291vhy.2 uc291vhy.1 uc291vhy.2 
ENSMUST00000206590.2 Gm44839 ENSMUST00000206590.2 Gm44839 (from geneSymbol) ENSMUST00000206590.1 uc291ouq.1 uc291ouq.2 uc291ouq.1 uc291ouq.2 
ENSMUST00000206600.2 2310001K20Rik ENSMUST00000206600.2 2310001K20Rik (from geneSymbol) AK009069 ENSMUST00000206600.1 uc291rnq.1 uc291rnq.2 uc291rnq.1 uc291rnq.2 
ENSMUST00000206608.2 Gm44818 ENSMUST00000206608.2 Gm44818 (from geneSymbol) ENSMUST00000206608.1 uc291pao.1 uc291pao.2 uc291pao.1 uc291pao.2 
ENSMUST00000206633.2 2200002A13Rik ENSMUST00000206633.2 2200002A13Rik (from geneSymbol) AK008616 ENSMUST00000206633.1 uc291vyy.1 uc291vyy.2 uc291vyy.1 uc291vyy.2 
ENSMUST00000206640.2 Gm45005 ENSMUST00000206640.2 Gm45005 (from geneSymbol) AJ409462 ENSMUST00000206640.1 uc291rlk.1 uc291rlk.2 uc291rlk.1 uc291rlk.2 
ENSMUST00000206653.2 ENSMUSG00000121284 ENSMUST00000206653.2 ENSMUSG00000121284 (from geneSymbol) ENSMUST00000206653.1 uc291ovb.1 uc291ovb.2 uc291ovb.1 uc291ovb.2 
ENSMUST00000206666.2 Gm44816 ENSMUST00000206666.2 Gm44816 (from geneSymbol) ENSMUST00000206666.1 uc291ozr.1 uc291ozr.2 uc291ozr.1 uc291ozr.2 
ENSMUST00000206668.2 4930486N12Rik ENSMUST00000206668.2 4930486N12Rik (from geneSymbol) AK015636 ENSMUST00000206668.1 uc291vci.1 uc291vci.2 uc291vci.1 uc291vci.2 
ENSMUST00000206670.2 Gm44895 ENSMUST00000206670.2 Gm44895 (from geneSymbol) AK047570 ENSMUST00000206670.1 uc291qiy.1 uc291qiy.2 uc291qiy.1 uc291qiy.2 
ENSMUST00000206671.2 Gm44834 ENSMUST00000206671.2 Gm44834 (from geneSymbol) AK053367 ENSMUST00000206671.1 uc291rmr.1 uc291rmr.2 uc291rmr.1 uc291rmr.2 
ENSMUST00000206676.2 Ceacam1 ENSMUST00000206676.2 Belongs to the immunoglobulin superfamily. CEA family. (from UniProt Q3LFS5) AB236332 CEACAM1a-4C1 Ceacam1 ENSMUST00000206676.1 Q3LFS5 Q3LFS5_MOUSE uc009fsy.1 uc009fsy.2 uc009fsy.3 Belongs to the immunoglobulin superfamily. CEA family. uc009fsy.1 uc009fsy.2 uc009fsy.3 
ENSMUST00000206678.2 Gm44601 ENSMUST00000206678.2 Gm44601 (from geneSymbol) AK034106 ENSMUST00000206678.1 uc291sss.1 uc291sss.2 uc291sss.1 uc291sss.2 
ENSMUST00000206684.2 4930533N22Rik ENSMUST00000206684.2 RIKEN cDNA 4930533N22 gene (from RefSeq NR_131122.1) ENSMUST00000206684.1 NR_131122 uc009hwi.1 uc009hwi.2 uc009hwi.3 uc009hwi.4 uc009hwi.1 uc009hwi.2 uc009hwi.3 uc009hwi.4 
ENSMUST00000206685.2 Zfp780b ENSMUST00000206685.2 zinc finger protein 780B, transcript variant 6 (from RefSeq NM_001419349.1) E9Q2S6 E9Q2S6_MOUSE ENSMUST00000206685.1 NM_001419349 Zfp780b uc009fxm.1 uc009fxm.2 uc009fxm.3 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009fxm.1 uc009fxm.2 uc009fxm.3 
ENSMUST00000206696.3 4933431G14Rik ENSMUST00000206696.3 RIKEN cDNA 4933431G14 gene, transcript variant 2 (from RefSeq NR_045163.1) ENSMUST00000206696.1 ENSMUST00000206696.2 NR_045163 uc009cia.1 uc009cia.2 uc009cia.3 uc009cia.4 uc009cia.1 uc009cia.2 uc009cia.3 uc009cia.4 
ENSMUST00000206705.3 Erfl ENSMUST00000206705.3 ETS repressor factor like, transcript variant 2 (from RefSeq NM_001395981.1) A0A140LIR9 A0A140LIR9_MOUSE ENSMUST00000206705.1 ENSMUST00000206705.2 Erfl Gm4881 NM_001395981 uc291mwz.1 uc291mwz.2 Nucleus Belongs to the ETS family. RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell differentiation sequence-specific DNA binding uc291mwz.1 uc291mwz.2 
ENSMUST00000206710.2 Gm45033 ENSMUST00000206710.2 Gm45033 (from geneSymbol) AK142505 ENSMUST00000206710.1 uc291utn.1 uc291utn.2 uc291utn.1 uc291utn.2 
ENSMUST00000206720.2 Cbl ENSMUST00000206720.2 Casitas B-lineage lymphoma (from RefSeq NM_007619.2) CBL_MOUSE ENSMUST00000206720.1 NM_007619 P22682 Q3U527 Q8CEA1 uc009pce.1 uc009pce.2 uc009pce.3 Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Ubiquitinates SPRY2 (By similarity). Ubiquitinates EGFR (By similarity). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-737' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3 (PubMed:10393178, PubMed:12649282, PubMed:19265199, PubMed:20100865, PubMed:9653117). In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (PubMed:29237719). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence= Protein modification; protein ubiquitination. Forms homodimers; IFT20 promotes the formation of stable homodimers (By similarity). Interacts (phosphorylated) with PIK3R1. Interacts with phosphorylated LAT2 (By similarity). Associates with NCK via its SH3 domain. The phosphorylated C-terminus interacts with CD2AP via its second SH3 domain. Binds to UBE2L3. Interacts with adapters SLA, SLA2 and with the phosphorylated C-terminus of SH2B2. Interacts with EGFR, SYK and ZAP70 via the highly conserved Cbl-N region. Interacts with FGR. Also interacts with BLK, SORBS1 and INPPL1/SHIP2. Interacts with CBLB. Interacts with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with ALK, AXL and FGFR2. Interacts with CSF1R, EPHB1, FLT1, KDR, PDGFRA and PDGFRB; regulates receptor degradation through ubiquitination. Interacts with HCK and LYN. Interacts with ATX2 (PubMed:18602463). Interacts with SH3KBP1 and this interaction is inhibited in the presence of SHKBP1 (PubMed:21830225). Interacts with SIGLEC10 (PubMed:23374343). Interacts with IFT20 (By similarity). Interacts with SPRY2; the interaction inhibits CBL- mediated ubiquitination of EGFR (By similarity). Interacts (phosphorylated at Tyr-780) with tensin TNS4 (via SH2 domain); the interaction is enhanced in the presence of EGF and reduces interaction of CBL with EGFR (By similarity). Interacts with EGFR; the interaction is reduced in the presence of TNS4 (By similarity). P22682; Q9JLQ0: Cd2ap; NbExp=5; IntAct=EBI-640919, EBI-644807; P22682; P13379: Cd5; NbExp=5; IntAct=EBI-640919, EBI-12600513; P22682; Q01279: Egfr; NbExp=2; IntAct=EBI-640919, EBI-6296235; P22682; P39688: Fyn; NbExp=5; IntAct=EBI-640919, EBI-524514; P22682; P16056: Met; NbExp=2; IntAct=EBI-640919, EBI-1798780; P22682; Q6Q899: Rigi; NbExp=3; IntAct=EBI-640919, EBI-6841237; P22682; P00533: EGFR; Xeno; NbExp=2; IntAct=EBI-640919, EBI-297353; Cytoplasm. Cell membrane Cell projection, cilium Golgi apparatus Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane. The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. Phosphorylated on tyrosine residues by ALK, EGFR, FGR, INSR, SYK, FYN and ZAP70. Phosphorylated on several tyrosine residues by constitutively activated FGFR3. Phosphorylated on tyrosine residues by activated PDGFRA and PDGFRB (By similarity). Phosphorylated on tyrosine residues in response to CSF1R, FLT1 and KIT signaling. Phosphorylated on tyrosine residues by HCK. Ubiquitinated, leading to its degradation via the proteasome. Ubiquitination is negatively regulated by IFT20. Note=Can be converted to an oncogenic protein by deletions or mutations that disturb its ability to down-regulate RTKs. This protein has one functional calcium-binding site. protein polyubiquitination phosphotyrosine binding ubiquitin-protein transferase activity epidermal growth factor receptor binding calcium ion binding protein binding cytoplasm Golgi apparatus cytosol plasma membrane focal adhesion cilium protein phosphorylation ubiquitin-dependent protein catabolic process protein monoubiquitination cellular response to DNA damage stimulus signal transduction cell surface receptor signaling pathway negative regulation of epidermal growth factor-activated receptor activity male gonad development response to gamma radiation positive regulation of phosphatidylinositol 3-kinase signaling response to activity membrane protein ubiquitination transferase activity SH3 domain binding protein kinase binding regulation of signaling axon growth cone receptor tyrosine kinase binding regulation of Rap protein signal transduction response to testosterone cellular response to platelet-derived growth factor stimulus phosphatidylinositol 3-kinase regulatory subunit binding negative regulation of epidermal growth factor receptor signaling pathway response to starvation mast cell granule cell projection negative regulation of apoptotic process mast cell degranulation membrane raft bone resorption response to ethanol response to antibiotic metal ion binding ephrin receptor binding positive regulation of receptor-mediated endocytosis perinuclear region of cytoplasm ubiquitin protein ligase activity neuron death cellular response to epidermal growth factor stimulus cellular response to oxygen-glucose deprivation negative regulation of neuron death cellular response to nerve growth factor stimulus protein tyrosine kinase binding regulation of platelet-derived growth factor receptor-alpha signaling pathway flotillin complex uc009pce.1 uc009pce.2 uc009pce.3 
ENSMUST00000206723.2 Gm45124 ENSMUST00000206723.2 Gm45124 (from geneSymbol) ENSMUST00000206723.1 uc291peo.1 uc291peo.2 uc291peo.1 uc291peo.2 
ENSMUST00000206736.2 Gm45095 ENSMUST00000206736.2 Gm45095 (from geneSymbol) ENSMUST00000206736.1 uc291olx.1 uc291olx.2 uc291olx.1 uc291olx.2 
ENSMUST00000206739.2 Gm44627 ENSMUST00000206739.2 Gm44627 (from geneSymbol) ENSMUST00000206739.1 uc291qxy.1 uc291qxy.2 uc291qxy.1 uc291qxy.2 
ENSMUST00000206742.3 Gm35665 ENSMUST00000206742.3 Gm35665 (from geneSymbol) AK080020 ENSMUST00000206742.1 ENSMUST00000206742.2 uc291ome.1 uc291ome.2 uc291ome.3 uc291ome.1 uc291ome.2 uc291ome.3 
ENSMUST00000206746.2 Gm45170 ENSMUST00000206746.2 Gm45170 (from geneSymbol) AK143774 ENSMUST00000206746.1 uc291rrm.1 uc291rrm.2 uc291rrm.1 uc291rrm.2 
ENSMUST00000206759.2 Gm44729 ENSMUST00000206759.2 Gm44729 (from geneSymbol) AK045638 ENSMUST00000206759.1 uc291vts.1 uc291vts.2 uc291vts.1 uc291vts.2 
ENSMUST00000206776.3 Gm44686 ENSMUST00000206776.3 Gm44686 (from geneSymbol) ENSMUST00000206776.1 ENSMUST00000206776.2 uc291rkn.1 uc291rkn.2 uc291rkn.3 uc291rkn.1 uc291rkn.2 uc291rkn.3 
ENSMUST00000206777.2 Zfp108 ENSMUST00000206777.2 zinc finger protein 108 (from RefSeq NM_018791.2) ENSMUST00000206777.1 NM_018791 Q8CCP6 Q8CCP6_MOUSE Zfp108 uc009fpc.1 uc009fpc.2 uc009fpc.3 uc009fpc.4 uc009fpc.5 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc009fpc.1 uc009fpc.2 uc009fpc.3 uc009fpc.4 uc009fpc.5 
ENSMUST00000206785.2 6720469O03Rik ENSMUST00000206785.2 6720469O03Rik (from geneSymbol) AK020153 ENSMUST00000206785.1 uc291opn.1 uc291opn.2 uc291opn.1 uc291opn.2 
ENSMUST00000206788.2 4933430L12Rik ENSMUST00000206788.2 4933430L12Rik (from geneSymbol) AK016998 ENSMUST00000206788.1 uc291mxw.1 uc291mxw.2 uc291mxw.1 uc291mxw.2 
ENSMUST00000206810.3 Gm38973 ENSMUST00000206810.3 Gm38973 (from geneSymbol) AK146287 ENSMUST00000206810.1 ENSMUST00000206810.2 uc057ltk.1 uc057ltk.2 uc057ltk.3 uc057ltk.4 uc057ltk.1 uc057ltk.2 uc057ltk.3 uc057ltk.4 
ENSMUST00000206812.2 Gm44815 ENSMUST00000206812.2 Gm44815 (from geneSymbol) AK052791 ENSMUST00000206812.1 uc291rpj.1 uc291rpj.2 uc291rpj.1 uc291rpj.2 
ENSMUST00000206822.2 Gm44706 ENSMUST00000206822.2 Gm44706 (from geneSymbol) ENSMUST00000206822.1 uc291rsd.1 uc291rsd.2 uc291rsd.1 uc291rsd.2 
ENSMUST00000206827.2 Gm44608 ENSMUST00000206827.2 Gm44608 (from geneSymbol) ENSMUST00000206827.1 uc291rnt.1 uc291rnt.2 uc291rnt.1 uc291rnt.2 
ENSMUST00000206829.3 Gm35040 ENSMUST00000206829.3 Gm35040 (from geneSymbol) ENSMUST00000206829.1 ENSMUST00000206829.2 uc291rri.1 uc291rri.2 uc291rri.3 uc291rri.1 uc291rri.2 uc291rri.3 
ENSMUST00000206832.2 Hnrnpul1 ENSMUST00000206832.2 heterogeneous nuclear ribonucleoprotein U-like 1, transcript variant 1 (from RefSeq NM_144922.3) ENSMUST00000206832.1 HNRL1_MOUSE Hnrpul1 NM_144922 Q3U201 Q3UPB0 Q6AZA7 Q8BY45 Q8K365 Q8VDM6 uc009ftu.1 uc009ftu.2 uc009ftu.3 uc009ftu.4 Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid- responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro (By similarity). Interacts with BRD7, PRMT2, TP53 and NXF1. Associates with histones and BRD7 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VDM6-1; Sequence=Displayed; Name=2; IsoId=Q8VDM6-2; Sequence=VSP_017553; Name=3; IsoId=Q8VDM6-3; Sequence=VSP_017554, VSP_017555; The RGG-box domain is methylated. Methylated. Sequence=AAH27844.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA binding nucleus nucleoplasm RNA processing response to virus enzyme binding uc009ftu.1 uc009ftu.2 uc009ftu.3 uc009ftu.4 
ENSMUST00000206838.2 Gm45051 ENSMUST00000206838.2 Gm45051 (from geneSymbol) BC054353 ENSMUST00000206838.1 uc012enj.1 uc012enj.2 uc012enj.1 uc012enj.2 
ENSMUST00000206841.2 Gm44664 ENSMUST00000206841.2 Gm44664 (from geneSymbol) AK137970 ENSMUST00000206841.1 uc291vej.1 uc291vej.2 uc291vej.1 uc291vej.2 
ENSMUST00000206842.2 Gm45017 ENSMUST00000206842.2 Gm45017 (from geneSymbol) AK054338 ENSMUST00000206842.1 uc291ure.1 uc291ure.2 uc291ure.1 uc291ure.2 
ENSMUST00000206856.2 Gm19514 ENSMUST00000206856.2 Gm19514 (from geneSymbol) ENSMUST00000206856.1 uc291wmv.1 uc291wmv.2 uc291wmv.1 uc291wmv.2 
ENSMUST00000206859.2 Gm45093 ENSMUST00000206859.2 Gm45093 (from geneSymbol) AK089818 ENSMUST00000206859.1 uc291vgy.1 uc291vgy.2 uc291vgy.1 uc291vgy.2 
ENSMUST00000206863.2 Gm44837 ENSMUST00000206863.2 Gm44837 (from geneSymbol) AK039003 ENSMUST00000206863.1 uc291ola.1 uc291ola.2 uc291ola.1 uc291ola.2 
ENSMUST00000206865.2 Klk2-ps ENSMUST00000206865.2 Klk2-ps (from geneSymbol) ENSMUST00000206865.1 uc291pbo.1 uc291pbo.2 uc291pbo.1 uc291pbo.2 
ENSMUST00000206867.2 9130221F21Rik ENSMUST00000206867.2 RIKEN cDNA 9130221F21 gene (from RefSeq NR_046180.1) ENSMUST00000206867.1 NR_046180 uc029vwc.1 uc029vwc.2 uc029vwc.1 uc029vwc.2 
ENSMUST00000206885.2 Gm45206 ENSMUST00000206885.2 Gm45206 (from geneSymbol) ENSMUST00000206885.1 uc291rtd.1 uc291rtd.2 uc291rtd.1 uc291rtd.2 
ENSMUST00000206886.2 Gm44718 ENSMUST00000206886.2 Gm44718 (from geneSymbol) ENSMUST00000206886.1 uc291qxq.1 uc291qxq.2 uc291qxq.1 uc291qxq.2 
ENSMUST00000206898.2 Gm44663 ENSMUST00000206898.2 Gm44663 (from geneSymbol) ENSMUST00000206898.1 uc291vek.1 uc291vek.2 uc291vek.1 uc291vek.2 
ENSMUST00000206905.2 Gm45691 ENSMUST00000206905.2 Gm45691 (from geneSymbol) ENSMUST00000206905.1 uc291ovd.1 uc291ovd.2 uc291ovd.1 uc291ovd.2 
ENSMUST00000206920.3 Or4k15b ENSMUST00000206920.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q05A45) A0A0U1RP48 ENSMUST00000206920.1 ENSMUST00000206920.2 Olfr725 Or4k15b Q05A45 Q05A45_MOUSE uc288tkd.1 uc288tkd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tkd.1 uc288tkd.2 
ENSMUST00000206927.2 Gm44765 ENSMUST00000206927.2 Gm44765 (from geneSymbol) ENSMUST00000206927.1 uc291qyu.1 uc291qyu.2 uc291qyu.1 uc291qyu.2 
ENSMUST00000206928.2 Gp6 ENSMUST00000206928.2 glycoprotein 6 platelet (from RefSeq NM_001163014.1) E9QPN2 ENSMUST00000206928.1 GPVI_MOUSE Gp6 NM_001163014 P0C191 uc009exk.1 uc009exk.2 uc009exk.3 uc009exk.4 Collagen receptor involved in collagen-induced platelet adhesion and activation (PubMed:16139873, PubMed:24368846). Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. Associated with Fc receptor gamma chain. The GPVI:FcRgamma complex is associated with the Src kinase family FYN and LYN. Interacts with TRAF4 (By similarity). Interacts with COL1A1, but not with COL4A4 (PubMed:24368846). Cell membrane ; Single-pass membrane protein Megakaryocytes and platelets. Expressed at embryonic day 13.5, 14.5 and 16.5. Expression decreases in intensity at day 18.5 and in 1.5 day-old newborn. Mice deficient in Gp6 show a complete protection against arterial thrombosis and induced pulmonary thromboembolism, without significant prolongation of bleeding time (PubMed:16139873). Mutant mice deficient in Gp6 and P3h2 are born at the expected Mendelian rate and have no visible phenotype (PubMed:24368846). collagen binding plasma membrane integral component of plasma membrane blood coagulation hemostasis membrane integral component of membrane collagen-activated tyrosine kinase receptor signaling pathway collagen receptor activity collagen-activated signaling pathway tetraspanin-enriched microdomain uc009exk.1 uc009exk.2 uc009exk.3 uc009exk.4 
ENSMUST00000206938.2 Gm45828 ENSMUST00000206938.2 Gm45828 (from geneSymbol) ENSMUST00000206938.1 LF195728 uc291hdw.1 uc291hdw.2 uc291hdw.1 uc291hdw.2 
ENSMUST00000206939.2 Gm44939 ENSMUST00000206939.2 Gm44939 (from geneSymbol) ENSMUST00000206939.1 uc291vsi.1 uc291vsi.2 uc291vsi.1 uc291vsi.2 
ENSMUST00000206943.2 Gm44508 ENSMUST00000206943.2 Gm44508 (from geneSymbol) AK038901 ENSMUST00000206943.1 uc291qko.1 uc291qko.2 uc291qko.1 uc291qko.2 
ENSMUST00000206944.2 Gm44672 ENSMUST00000206944.2 Gm44672 (from geneSymbol) BC021948 ENSMUST00000206944.1 uc291wdm.1 uc291wdm.2 uc291wdm.1 uc291wdm.2 
ENSMUST00000206950.2 Gm44737 ENSMUST00000206950.2 Gm44737 (from geneSymbol) ENSMUST00000206950.1 uc291rlb.1 uc291rlb.2 uc291rlb.1 uc291rlb.2 
ENSMUST00000206960.2 Zfp109 ENSMUST00000206960.2 Zfp109 (from geneSymbol) A0A0U1RPC5 A0A0U1RPC5_MOUSE BC119619 ENSMUST00000206960.1 Zfp109 uc291mth.1 uc291mth.2 nucleic acid binding regulation of transcription, DNA-templated biological_process metal ion binding uc291mth.1 uc291mth.2 
ENSMUST00000206967.2 Gm20274 ENSMUST00000206967.2 Gm20274 (from geneSymbol) BC016578 ENSMUST00000206967.1 uc291vfe.1 uc291vfe.2 uc291vfe.1 uc291vfe.2 
ENSMUST00000206975.2 Gm44771 ENSMUST00000206975.2 Gm44771 (from geneSymbol) ENSMUST00000206975.1 LF195559 uc291frt.1 uc291frt.2 uc291frt.1 uc291frt.2 
ENSMUST00000206978.2 Gm44721 ENSMUST00000206978.2 Gm44721 (from geneSymbol) ENSMUST00000206978.1 uc291qzh.1 uc291qzh.2 uc291qzh.1 uc291qzh.2 
ENSMUST00000206984.2 Pak1 ENSMUST00000206984.2 p21 (RAC1) activated kinase 1, transcript variant 5 (from RefSeq NM_001357365.2) ENSMUST00000206984.1 G5E884 G5E884_MOUSE NM_001357365 Pak1 uc291svp.1 uc291svp.2 Cytoplasm nucleotide binding response to hypoxia ruffle positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity collagen binding ATP binding nucleoplasm cytoplasm cytosol actin filament plasma membrane cell-cell junction chromatin remodeling protein phosphorylation cellular response to DNA damage stimulus positive regulation of cell proliferation response to organic substance positive regulation of fibroblast migration intercalated disc membrane kinase activity phosphorylation transferase activity protein kinase binding cerebellum development establishment of cell polarity Z disc lamellipodium positive regulation of cell migration axon dendrite positive regulation of microtubule polymerization actin cytoskeleton reorganization nuclear membrane cellular response to insulin stimulus regulation of actin cytoskeleton organization macromolecular complex positive regulation of peptidyl-serine phosphorylation positive regulation of intracellular estrogen receptor signaling pathway wound healing positive regulation of JUN kinase activity positive regulation of axon extension positive regulation of insulin receptor signaling pathway protein autophosphorylation hepatocyte growth factor receptor signaling pathway Rac GTPase binding branching morphogenesis of an epithelial tube neuron projection morphogenesis positive regulation of stress fiber assembly negative regulation of cell proliferation involved in contact inhibition negative regulation of cell growth involved in cardiac muscle cell development invadopodium positive regulation of protein targeting to membrane positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration uc291svp.1 uc291svp.2 
ENSMUST00000206991.2 Gm45715 ENSMUST00000206991.2 Gm45715 (from geneSymbol) ENSMUST00000206991.1 uc291rjd.1 uc291rjd.2 uc291rjd.1 uc291rjd.2 
ENSMUST00000206993.3 4921513I08Rik ENSMUST00000206993.3 4921513I08Rik (from geneSymbol) AK014883 ENSMUST00000206993.1 ENSMUST00000206993.2 uc291rob.1 uc291rob.2 uc291rob.3 uc291rob.1 uc291rob.2 uc291rob.3 
ENSMUST00000207005.2 BC060293 ENSMUST00000207005.2 BC060293 (from geneSymbol) ENSMUST00000207005.1 LF196213 uc291okh.1 uc291okh.2 uc291okh.1 uc291okh.2 
ENSMUST00000207008.2 Gm44792 ENSMUST00000207008.2 Gm44792 (from geneSymbol) DQ726971 ENSMUST00000207008.1 uc291raa.1 uc291raa.2 uc291raa.1 uc291raa.2 
ENSMUST00000207013.2 Gm45094 ENSMUST00000207013.2 Gm45094 (from geneSymbol) ENSMUST00000207013.1 uc291olw.1 uc291olw.2 uc291olw.1 uc291olw.2 
ENSMUST00000207018.2 Gm44814 ENSMUST00000207018.2 Gm44814 (from geneSymbol) ENSMUST00000207018.1 uc291paz.1 uc291paz.2 uc291paz.1 uc291paz.2 
ENSMUST00000207023.2 Kdm3a ENSMUST00000207023.2 lysine (K)-specific demethylase 3A, transcript variant 3 (from RefSeq NM_001362200.1) ENSMUST00000207023.1 Jhdm2a Jmjd1a KDM3A_MOUSE Kiaa0742 NM_001362200 Q2MJQ6 Q3TKW8 Q3UML3 Q6PCM1 Q6ZQ57 Q8K2J6 Q8K2K4 Q8R350 uc291fqz.1 uc291fqz.2 Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation (By similarity). Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin (PubMed:17943087). Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. Reaction=2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60188, Rhea:RHEA-COMP:15541, Rhea:RHEA- COMP:15546, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61976; EC=1.14.11.65; Evidence=; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Cytoplasm Nucleus Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PCM1-1; Sequence=Displayed; Name=2; IsoId=Q6PCM1-2; Sequence=VSP_018296, VSP_018297; Highly expressed in testis (at protein level). Also expressed at high levels in tissues responsive to sympathetic nerve activity such as brown adipose tissue and skeletal muscle. Expression increases significantly during spermatogenesis with a 70-fold increase from day 7 testis to day 30 testis. First detected in the late pachytene stage, increases in diplotene and secondary spermatocytes and reaches its highest levels in round spermatids. By beta-adrenergic stimulation (at protein level). The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors. Spermatogenesis defects and adult obesity. Belongs to the JHDM2 histone demethylase family. Sequence=BAC98014.1; Type=Erroneous initiation; Evidence=; chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding iron ion binding protein binding nucleus nucleoplasm cytoplasm chromatin organization spermatogenesis spermatid nucleus elongation hormone-mediated signaling pathway regulation of gene expression positive regulation of gene expression oxidoreductase activity cell differentiation androgen receptor signaling pathway chromatin DNA binding histone demethylase activity (H3-K9 specific) histone H3-K9 demethylation histone H3-K9 dimethylation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter formaldehyde biosynthetic process metal ion binding androgen receptor binding dioxygenase activity negative regulation of histone H3-K9 methylation oxidation-reduction process cellular response to leukemia inhibitory factor regulation of stem cell population maintenance regulation of stem cell differentiation uc291fqz.1 uc291fqz.2 
ENSMUST00000207029.2 Gm45222 ENSMUST00000207029.2 Gm45222 (from geneSymbol) ENSMUST00000207029.1 uc291sns.1 uc291sns.2 uc291sns.1 uc291sns.2 
ENSMUST00000207035.2 Gm44622 ENSMUST00000207035.2 Gm44622 (from geneSymbol) AK136672 ENSMUST00000207035.1 uc291yav.1 uc291yav.2 uc291yav.1 uc291yav.2 
ENSMUST00000207036.2 Gm10584 ENSMUST00000207036.2 predicted gene 10584 (from RefSeq NR_028578.1) ENSMUST00000207036.1 NR_028578 uc012fvc.1 uc012fvc.2 uc012fvc.3 uc012fvc.1 uc012fvc.2 uc012fvc.3 
ENSMUST00000207037.2 Gm45223 ENSMUST00000207037.2 Gm45223 (from geneSymbol) ENSMUST00000207037.1 uc291snr.1 uc291snr.2 uc291snr.1 uc291snr.2 
ENSMUST00000207038.2 Nhsl1 ENSMUST00000207038.2 NHS like 1, transcript variant 3 (from RefSeq NM_001405956.1) A0A140LIZ7 A0A140LIZ7_MOUSE ENSMUST00000207038.1 NM_001405956 Nhsl1 uc287puo.1 uc287puo.2 uc287puo.1 uc287puo.2 
ENSMUST00000207045.2 Gm14377 ENSMUST00000207045.2 Gm14377 (from geneSymbol) AK034312 ENSMUST00000207045.1 uc291qds.1 uc291qds.2 uc291qds.1 uc291qds.2 
ENSMUST00000207047.2 Gm44967 ENSMUST00000207047.2 Gm44967 (from geneSymbol) AK038234 ENSMUST00000207047.1 uc057cai.1 uc057cai.2 uc057cai.1 uc057cai.2 
ENSMUST00000207050.2 Gm44973 ENSMUST00000207050.2 Gm44973 (from geneSymbol) A0A140LJJ1 A0A140LJJ1_MOUSE AK154328 ENSMUST00000207050.1 Gm44973 uc291kxy.1 uc291kxy.2 nucleic acid binding uc291kxy.1 uc291kxy.2 
ENSMUST00000207051.2 4930560O18Rik ENSMUST00000207051.2 4930560O18Rik (from geneSymbol) ENSMUST00000207051.1 uc291uzi.1 uc291uzi.2 uc291uzi.1 uc291uzi.2 
ENSMUST00000207056.2 Gm44995 ENSMUST00000207056.2 Gm44995 (from geneSymbol) ENSMUST00000207056.1 uc291slt.1 uc291slt.2 uc291slt.1 uc291slt.2 
ENSMUST00000207066.2 Gm45088 ENSMUST00000207066.2 Gm45088 (from geneSymbol) ENSMUST00000207066.1 uc291saw.1 uc291saw.2 uc291saw.1 uc291saw.2 
ENSMUST00000207091.2 Gm44998 ENSMUST00000207091.2 Gm44998 (from geneSymbol) AK041517 ENSMUST00000207091.1 uc291xnz.1 uc291xnz.2 uc291xnz.1 uc291xnz.2 
ENSMUST00000207093.3 Or5b121 ENSMUST00000207093.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQQ6) ENSMUST00000207093.1 ENSMUST00000207093.2 Olfr1480 Olfr1484 Or5b121 Q7TQQ6 Q7TQQ6_MOUSE uc289rfm.1 uc289rfm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rfm.1 uc289rfm.2 
ENSMUST00000207096.2 Gm45084 ENSMUST00000207096.2 Gm45084 (from geneSymbol) ENSMUST00000207096.1 LF245404 uc291uuw.1 uc291uuw.2 uc291uuw.1 uc291uuw.2 
ENSMUST00000207104.2 Gm44847 ENSMUST00000207104.2 Gm44847 (from geneSymbol) AK140525 ENSMUST00000207104.1 uc291skt.1 uc291skt.2 uc291skt.1 uc291skt.2 
ENSMUST00000207107.2 Zzef1 ENSMUST00000207107.2 zinc finger, ZZ-type with EF hand domain 1, transcript variant 1 (from RefSeq NM_001427298.1) A0A140LJ04 A0A140LJ04_MOUSE ENSMUST00000207107.1 NM_001427298 Zzef1 uc287zxq.1 uc287zxq.2 calcium ion binding zinc ion binding metal ion binding uc287zxq.1 uc287zxq.2 
ENSMUST00000207112.2 Gm45160 ENSMUST00000207112.2 Gm45160 (from geneSymbol) ENSMUST00000207112.1 uc291yab.1 uc291yab.2 uc291yab.1 uc291yab.2 
ENSMUST00000207113.3 Or5b107 ENSMUST00000207113.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEV7) ENSMUST00000207113.1 ENSMUST00000207113.2 Olfr1461 Or5b107 Q8VEV7 Q8VEV7_MOUSE uc289rel.1 uc289rel.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rel.1 uc289rel.2 
ENSMUST00000207119.3 Gm44724 ENSMUST00000207119.3 Gm44724 (from geneSymbol) ENSMUST00000207119.1 ENSMUST00000207119.2 uc291scp.1 uc291scp.2 uc291scp.3 uc291scp.1 uc291scp.2 uc291scp.3 
ENSMUST00000207124.3 Or5b112 ENSMUST00000207124.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFW4) ENSMUST00000207124.1 ENSMUST00000207124.2 Olfr1466 Or5b112 Q8VFW4 Q8VFW4_MOUSE uc289res.1 uc289res.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289res.1 uc289res.2 
ENSMUST00000207127.2 Gm44846 ENSMUST00000207127.2 Gm44846 (from geneSymbol) AK046851 ENSMUST00000207127.1 uc291skv.1 uc291skv.2 uc291skv.1 uc291skv.2 
ENSMUST00000207133.2 A930037H05Rik ENSMUST00000207133.2 A930037H05Rik (from geneSymbol) AK041735 ENSMUST00000207133.1 uc288ebj.1 uc288ebj.2 uc288ebj.1 uc288ebj.2 
ENSMUST00000207134.2 Gm44660 ENSMUST00000207134.2 Gm44660 (from geneSymbol) DQ719215 ENSMUST00000207134.1 uc291mnh.1 uc291mnh.2 uc291mnh.1 uc291mnh.2 
ENSMUST00000207140.2 Gm44752 ENSMUST00000207140.2 Gm44752 (from geneSymbol) ENSMUST00000207140.1 LF196361 uc291rbq.1 uc291rbq.2 uc291rbq.1 uc291rbq.2 
ENSMUST00000207150.2 Gm44585 ENSMUST00000207150.2 Gm44585 (from geneSymbol) AK047507 ENSMUST00000207150.1 uc291ldo.1 uc291ldo.2 uc291ldo.1 uc291ldo.2 
ENSMUST00000207156.2 Cpeb1os1 ENSMUST00000207156.2 Cpeb1os1 (from geneSymbol) AK017413 ENSMUST00000207156.1 uc291rze.1 uc291rze.2 uc291rze.1 uc291rze.2 
ENSMUST00000207166.2 Gm44586 ENSMUST00000207166.2 Gm44586 (from geneSymbol) ENSMUST00000207166.1 uc291ldr.1 uc291ldr.2 uc291ldr.1 uc291ldr.2 
ENSMUST00000207173.3 Zfp582 ENSMUST00000207173.3 zinc finger protein 582 (from RefSeq NM_001402539.1) A0A1B0GSS6 A0A1B0GSS6_MOUSE ENSMUST00000207173.1 ENSMUST00000207173.2 Gm3854 NM_001402539 Zfp582 uc291lbk.1 uc291lbk.2 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc291lbk.1 uc291lbk.2 
ENSMUST00000207177.2 Gm44559 ENSMUST00000207177.2 Gm44559 (from geneSymbol) AK038761 ENSMUST00000207177.1 uc291qmx.1 uc291qmx.2 uc291qmx.1 uc291qmx.2 
ENSMUST00000207179.2 Gm45098 ENSMUST00000207179.2 Gm45098 (from geneSymbol) ENSMUST00000207179.1 uc291rcs.1 uc291rcs.2 uc291rcs.1 uc291rcs.2 
ENSMUST00000207184.3 Gm10610 ENSMUST00000207184.3 Gm10610 (from geneSymbol) AK082155 ENSMUST00000207184.1 ENSMUST00000207184.2 uc291scu.1 uc291scu.2 uc291scu.3 uc291scu.1 uc291scu.2 uc291scu.3 
ENSMUST00000207186.4 Or5an1 ENSMUST00000207186.4 olfactory receptor family 5 subfamily AN member 1 (from RefSeq NM_146685.3) A0A140LIR4 ENSMUST00000207186.1 ENSMUST00000207186.2 ENSMUST00000207186.3 F7CP35 NM_146685 Olfr1433 Olfr1434 Or5an1 Q7TQR9 Q7TQR9_MOUSE uc008gtv.1 uc008gtv.2 uc008gtv.3 uc008gtv.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB174462.1, CB174466.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception detection of chemical stimulus involved in sensory perception of smell uc008gtv.1 uc008gtv.2 uc008gtv.3 uc008gtv.4 
ENSMUST00000207187.2 Gm45201 ENSMUST00000207187.2 Gm45201 (from geneSymbol) AK036244 ENSMUST00000207187.1 uc291sqx.1 uc291sqx.2 uc291sqx.1 uc291sqx.2 
ENSMUST00000207189.2 E230032D23Rik ENSMUST00000207189.2 RIKEN cDNA E230032D23 gene, transcript variant 2 (from RefSeq NR_153818.2) ENSMUST00000207189.1 NR_153818 uc009kpr.1 uc009kpr.2 uc009kpr.3 uc009kpr.4 uc009kpr.1 uc009kpr.2 uc009kpr.3 uc009kpr.4 
ENSMUST00000207190.2 Gm44742 ENSMUST00000207190.2 Gm44742 (from geneSymbol) AK037653 ENSMUST00000207190.1 uc291qmm.1 uc291qmm.2 uc291qmm.1 uc291qmm.2 
ENSMUST00000207191.2 Gm44914 ENSMUST00000207191.2 Gm44914 (from geneSymbol) AK082246 ENSMUST00000207191.1 uc291szn.1 uc291szn.2 uc291szn.1 uc291szn.2 
ENSMUST00000207192.2 Gm6882 ENSMUST00000207192.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; (from UniProt J3KMT3) ENSMUST00000207192.1 Gm6882 J3KMT3 J3KMT3_MOUSE uc291mor.1 uc291mor.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. nucleotide binding microtubule cytoskeleton organization protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm protein phosphorylation intracellular signal transduction tau-protein kinase activity uc291mor.1 uc291mor.2 
ENSMUST00000207194.2 Gm44562 ENSMUST00000207194.2 Gm44562 (from geneSymbol) ENSMUST00000207194.1 LF204625 uc291qmw.1 uc291qmw.2 uc291qmw.1 uc291qmw.2 
ENSMUST00000207195.2 Gm44789 ENSMUST00000207195.2 Gm44789 (from geneSymbol) ENSMUST00000207195.1 uc291ybx.1 uc291ybx.2 uc291ybx.1 uc291ybx.2 
ENSMUST00000207198.2 A230103L15Rik ENSMUST00000207198.2 A230103L15Rik (from geneSymbol) ENSMUST00000207198.1 LF196348 uc291qnh.1 uc291qnh.2 uc291qnh.1 uc291qnh.2 
ENSMUST00000207202.2 Gm44679 ENSMUST00000207202.2 Gm44679 (from geneSymbol) ENSMUST00000207202.1 uc291sqc.1 uc291sqc.2 uc291sqc.1 uc291sqc.2 
ENSMUST00000207222.3 Gm34908 ENSMUST00000207222.3 Gm34908 (from geneSymbol) AK080057 ENSMUST00000207222.1 ENSMUST00000207222.2 uc009kbz.1 uc009kbz.2 uc009kbz.3 uc009kbz.1 uc009kbz.2 uc009kbz.3 
ENSMUST00000207232.2 Gm32061 ENSMUST00000207232.2 predicted gene, 32061 (from RefSeq NR_166566.1) ENSMUST00000207232.1 NR_166566 uc291qxb.1 uc291qxb.2 uc291qxb.1 uc291qxb.2 
ENSMUST00000207234.2 Gm45132 ENSMUST00000207234.2 Gm45132 (from geneSymbol) AK044350 ENSMUST00000207234.1 uc291sxg.1 uc291sxg.2 uc291sxg.1 uc291sxg.2 
ENSMUST00000207241.3 Or5an1b ENSMUST00000207241.3 olfactory receptor family 5 subfamily AN member 1B (from RefSeq NM_001011839.2) A0A140LHA1 ENSMUST00000207241.1 ENSMUST00000207241.2 NM_001011839 Olfr1437 Or5an1b Q7TQR7 Q7TQR7_MOUSE uc008gtx.1 uc008gtx.2 uc008gtx.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB173567.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gtx.1 uc008gtx.2 uc008gtx.3 
ENSMUST00000207245.3 Gm44632 ENSMUST00000207245.3 Gm44632 (from geneSymbol) ENSMUST00000207245.1 ENSMUST00000207245.2 uc291nqm.1 uc291nqm.2 uc291nqm.3 uc291nqm.1 uc291nqm.2 uc291nqm.3 
ENSMUST00000207246.4 Or5b109 ENSMUST00000207246.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQR3) ENSMUST00000207246.1 ENSMUST00000207246.2 ENSMUST00000207246.3 Olfr1457 Olfr1463 Or5b109 Q7TQR3 Q7TQR3_MOUSE uc289reo.1 uc289reo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289reo.1 uc289reo.2 
ENSMUST00000207250.2 Gm45117 ENSMUST00000207250.2 Gm45117 (from geneSymbol) ENSMUST00000207250.1 uc291xxx.1 uc291xxx.2 uc291xxx.1 uc291xxx.2 
ENSMUST00000207259.2 Gm44893 ENSMUST00000207259.2 Gm44893 (from geneSymbol) AK086971 ENSMUST00000207259.1 uc009kca.1 uc009kca.2 uc009kca.1 uc009kca.2 
ENSMUST00000207266.2 Gm44775 ENSMUST00000207266.2 Gm44775 (from geneSymbol) AK054228 ENSMUST00000207266.1 uc291xsj.1 uc291xsj.2 uc291xsj.1 uc291xsj.2 
ENSMUST00000207270.2 Lyrm1 ENSMUST00000207270.2 May promote cell proliferation and inhibition of apoptosis of preadipocytes. (from UniProt Q9CQB7) AK157931 ENSMUST00000207270.1 LYRM1_MOUSE Q3TZE0 Q9CQB7 uc009jmb.1 uc009jmb.2 May promote cell proliferation and inhibition of apoptosis of preadipocytes. Belongs to the complex I LYR family. molecular_function nucleoplasm mitochondrion biological_process midbody uc009jmb.1 uc009jmb.2 
ENSMUST00000207282.2 Tacc2 ENSMUST00000207282.2 transforming, acidic coiled-coil containing protein 2, transcript variant 4 (from RefSeq NM_001347637.2) ENSMUST00000207282.1 MNCb-3527 NM_001347637 Q3TN02 Q811U0 Q8BQD4 Q99KQ6 Q9JJG0 TACC2_MOUSE uc009kam.1 uc009kam.2 uc009kam.3 This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK165603.1, SRR7345562.4972152.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules (By similarity). Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF (By similarity). Interacts with CCDC100/CEP120. Cytoplasm Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9JJG0-1; Sequence=Displayed; Name=2; IsoId=Q9JJG0-2; Sequence=VSP_022160, VSP_022161; Name=3; IsoId=Q9JJG0-3; Sequence=VSP_022160, VSP_022161, VSP_022162, VSP_022164, VSP_022165; Name=4; IsoId=Q9JJG0-4; Sequence=VSP_022159, VSP_022162, VSP_022163, VSP_022164, VSP_022165; Expressed in brain, kidney, lung, thymus and ovary. Not detectable in normal tissues at protein level. Phosphorylated; which is required for localization in centrosome. Mice develop normally, are fertile, and do not present elevated tumorization rates. Cells deficient in TACC2 divide normally and do not show any change in the frequency of apoptosis induction. Belongs to the TACC family. microtubule cytoskeleton organization nucleus nucleoplasm cytoplasm microtubule organizing center cytosol cytoskeleton plasma membrane mitotic spindle organization cell proliferation protein domain specific binding cerebral cortex development neurogenesis interkinetic nuclear migration astral microtubule organization regulation of microtubule-based process nuclear hormone receptor binding uc009kam.1 uc009kam.2 uc009kam.3 
ENSMUST00000207287.3 Or5b114-ps1 ENSMUST00000207287.3 Or5b114-ps1 (from geneSymbol) ENSMUST00000207287.1 ENSMUST00000207287.2 NR_190787 uc289reu.1 uc289reu.2 uc289reu.1 uc289reu.2 
ENSMUST00000207292.2 Gm44864 ENSMUST00000207292.2 Gm44864 (from geneSymbol) ENSMUST00000207292.1 uc291ujh.1 uc291ujh.2 uc291ujh.1 uc291ujh.2 
ENSMUST00000207311.2 Gm44550 ENSMUST00000207311.2 Gm44550 (from geneSymbol) AK087364 ENSMUST00000207311.1 uc291uwe.1 uc291uwe.2 uc291uwe.1 uc291uwe.2 
ENSMUST00000207316.2 Gm45161 ENSMUST00000207316.2 Gm45161 (from geneSymbol) ENSMUST00000207316.1 uc291spn.1 uc291spn.2 uc291spn.1 uc291spn.2 
ENSMUST00000207320.2 Bend2 ENSMUST00000207320.2 Bend2 (from geneSymbol) A0A140LIQ5 A0A140LIQ5_MOUSE Bend2 ENSMUST00000207320.1 uc292roo.1 uc292roo.2 molecular_function cellular_component biological_process uc292roo.1 uc292roo.2 
ENSMUST00000207324.2 Gm44936 ENSMUST00000207324.2 Gm44936 (from geneSymbol) ENSMUST00000207324.1 uc291qmc.1 uc291qmc.2 uc291qmc.1 uc291qmc.2 
ENSMUST00000207326.2 Gm45845 ENSMUST00000207326.2 Gm45845 (from geneSymbol) ENSMUST00000207326.1 uc291saj.1 uc291saj.2 uc291saj.1 uc291saj.2 
ENSMUST00000207339.4 Or6z6 ENSMUST00000207339.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQV2) A0A140LJA7 ENSMUST00000207339.1 ENSMUST00000207339.2 ENSMUST00000207339.3 Olfr1347 Or6z6 Q7TQV2 Q7TQV2_MOUSE uc291lcf.1 uc291lcf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291lcf.1 uc291lcf.2 
ENSMUST00000207340.3 Or5b111 ENSMUST00000207340.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQR2) A0A140LI26 ENSMUST00000207340.1 ENSMUST00000207340.2 Olfr1453 Olfr1465 Or5b111 Q7TQR2 Q7TQR2_MOUSE uc289rer.1 uc289rer.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rer.1 uc289rer.2 
ENSMUST00000207347.2 Zfp78 ENSMUST00000207347.2 zinc finger protein 78, transcript variant 1 (from RefSeq NM_001025163.1) ENSMUST00000207347.1 NM_001025163 Q5U406 Q5U406_MOUSE Zfp78 uc009fbf.1 uc009fbf.2 uc009fbf.3 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc009fbf.1 uc009fbf.2 uc009fbf.3 
ENSMUST00000207352.2 Gm31401 ENSMUST00000207352.2 Gm31401 (from geneSymbol) ENSMUST00000207352.1 uc291yac.1 uc291yac.2 uc291yac.1 uc291yac.2 
ENSMUST00000207355.2 Gm45838 ENSMUST00000207355.2 Gm45838 (from geneSymbol) ENSMUST00000207355.1 uc291sde.1 uc291sde.2 uc291sde.1 uc291sde.2 
ENSMUST00000207366.2 Gm45041 ENSMUST00000207366.2 Gm45041 (from geneSymbol) AK141290 ENSMUST00000207366.1 uc291qfp.1 uc291qfp.2 uc291qfp.1 uc291qfp.2 
ENSMUST00000207368.2 Gm45045 ENSMUST00000207368.2 Gm45045 (from geneSymbol) ENSMUST00000207368.1 uc291ych.1 uc291ych.2 uc291ych.1 uc291ych.2 
ENSMUST00000207369.2 Gm44723 ENSMUST00000207369.2 Gm44723 (from geneSymbol) ENSMUST00000207369.1 uc291scr.1 uc291scr.2 uc291scr.1 uc291scr.2 
ENSMUST00000207374.2 Gm44773 ENSMUST00000207374.2 Gm44773 (from geneSymbol) ENSMUST00000207374.1 uc291uex.1 uc291uex.2 uc291uex.1 uc291uex.2 
ENSMUST00000207379.3 Gm44785 ENSMUST00000207379.3 Gm44785 (from geneSymbol) AK136601 ENSMUST00000207379.1 ENSMUST00000207379.2 uc291ycf.1 uc291ycf.2 uc291ycf.3 uc291ycf.1 uc291ycf.2 uc291ycf.3 
ENSMUST00000207396.2 Gm44784 ENSMUST00000207396.2 Gm44784 (from geneSymbol) ENSMUST00000207396.1 uc291ycg.1 uc291ycg.2 uc291ycg.1 uc291ycg.2 
ENSMUST00000207398.3 Gm34964 ENSMUST00000207398.3 Gm34964 (from geneSymbol) ENSMUST00000207398.1 ENSMUST00000207398.2 KY468174 uc291xqq.1 uc291xqq.2 uc291xqq.3 uc291xqq.1 uc291xqq.2 uc291xqq.3 
ENSMUST00000207399.2 Gm44587 ENSMUST00000207399.2 Gm44587 (from geneSymbol) AK148719 ENSMUST00000207399.1 uc291lds.1 uc291lds.2 uc291lds.1 uc291lds.2 
ENSMUST00000207402.2 Gm44647 ENSMUST00000207402.2 Gm44647 (from geneSymbol) ENSMUST00000207402.1 uc291wfp.1 uc291wfp.2 uc291wfp.1 uc291wfp.2 
ENSMUST00000207405.2 Dnajb13 ENSMUST00000207405.2 DnaJ heat shock protein family (Hsp40) member B13, transcript variant 1 (from RefSeq NM_153527.3) DJB13_MOUSE ENSMUST00000207405.1 NM_153527 Q80Y75 Q8CJA2 Tsarg Tsarg3 Tsarg6 uc009inc.1 uc009inc.2 uc009inc.3 Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. Homodimer (By similarity). Component of the axonemal radial spoke complex 1 (RS1), at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB (PubMed:36417862). Interacts with SUN5 (PubMed:29298896). Interacts with IQUB (PubMed:36417862). Cell projection, cilium, flagellum Cell projection, cilium Note=Localizes both to epithelial motile cilium and the sperm flagellum (By similarity). In spermatids, rapidly enriched in the coupling apparatus with the elongation of the spermatid. Tightly attached to the implantation fossa during the maturation of the spermatid. In mature spermatzoa evenly distributed along the flagellum at the radial spoke of the axoneme (PubMed:29298896, PubMed:19919626). Expressed in ciliated cell-containing tissues such as testis, brain, lung, ovary and oviduct. Expressed during spermiogenesis. protein binding cytoplasm cytosol cilium axoneme protein folding cell projection organization motile cilium sperm flagellum cell projection unfolded protein binding chaperone mediated protein folding requiring cofactor chaperone binding sperm connecting piece axonemal central apparatus assembly uc009inc.1 uc009inc.2 uc009inc.3 
ENSMUST00000207411.2 2900027M19Rik ENSMUST00000207411.2 2900027M19Rik (from geneSymbol) AK013604 ENSMUST00000207411.1 uc291ybn.1 uc291ybn.2 uc291ybn.1 uc291ybn.2 
ENSMUST00000207413.3 Gm44577 ENSMUST00000207413.3 Gm44577 (from geneSymbol) AK133058 ENSMUST00000207413.1 ENSMUST00000207413.2 uc289oop.1 uc289oop.2 uc289oop.3 uc289oop.1 uc289oop.2 uc289oop.3 
ENSMUST00000207417.3 Nrg1 ENSMUST00000207417.3 Membrane ; Single- pass type I membrane protein (from UniProt A0A140LIP8) A0A140LIP8 A0A140LIP8_MOUSE AY648976 ENSMUST00000207417.1 ENSMUST00000207417.2 Nrg1 uc291zep.1 uc291zep.2 uc291zep.3 Membrane ; Single- pass type I membrane protein Belongs to the neuregulin family. Lacks conserved residue(s) required for the propagation of feature annotation. MAPK cascade cell morphogenesis cardiac conduction system development transcription cofactor activity receptor binding ErbB-2 class receptor binding extracellular space cytoplasm plasma membrane integral component of plasma membrane activation of transmembrane receptor protein tyrosine kinase activity nervous system development synapse assembly peripheral nervous system development heart development muscle organ development locomotory behavior glial cell differentiation positive regulation of gene expression membrane integral component of membrane cell migration glial cell fate commitment chemorepulsion involved in interneuron migration from the subpallium to the cortex myelination in peripheral nervous system protein tyrosine kinase activator activity axon receptor tyrosine kinase binding neuromuscular junction intracellular signal transduction negative regulation of protein catabolic process cellular protein complex disassembly synapse neurotransmitter receptor metabolic process chemorepellent activity regulation of cell differentiation positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of Ras protein signal transduction neuron fate commitment oligodendrocyte differentiation cardiac muscle tissue development positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein kinase B signaling positive regulation of protein tyrosine kinase activity positive regulation of calcineurin-NFAT signaling cascade glutamatergic synapse GABA-ergic synapse postsynapse to nucleus signaling pathway negative regulation of neuron migration uc291zep.1 uc291zep.2 uc291zep.3 
ENSMUST00000207423.2 Gm44907 ENSMUST00000207423.2 Gm44907 (from geneSymbol) AK045119 ENSMUST00000207423.1 uc291spg.1 uc291spg.2 uc291spg.1 uc291spg.2 
ENSMUST00000207427.2 Gm45102 ENSMUST00000207427.2 Gm45102 (from geneSymbol) AK015121 ENSMUST00000207427.1 uc291rew.1 uc291rew.2 uc291rew.1 uc291rew.2 
ENSMUST00000207434.2 Gm45200 ENSMUST00000207434.2 Gm45200 (from geneSymbol) AK042810 ENSMUST00000207434.1 uc291srr.1 uc291srr.2 uc291srr.1 uc291srr.2 
ENSMUST00000207435.2 Gm44975 ENSMUST00000207435.2 Gm44975 (from geneSymbol) ENSMUST00000207435.1 uc291syb.1 uc291syb.2 uc291syb.1 uc291syb.2 
ENSMUST00000207438.3 Gm45164 ENSMUST00000207438.3 Gm45164 (from geneSymbol) ENSMUST00000207438.1 ENSMUST00000207438.2 uc291ytu.1 uc291ytu.2 uc291ytu.3 uc291ytu.1 uc291ytu.2 uc291ytu.3 
ENSMUST00000207439.2 Fam24a ENSMUST00000207439.2 Secreted (from UniProt Q8CF27) AK006815 ENSMUST00000207439.1 FA24A_MOUSE Q8CF27 uc291whm.1 uc291whm.2 Secreted Belongs to the FAM24 family. molecular_function cellular_component extracellular region biological_process uc291whm.1 uc291whm.2 
ENSMUST00000207441.2 Gm44692 ENSMUST00000207441.2 Gm44692 (from geneSymbol) ENSMUST00000207441.1 uc291rgf.1 uc291rgf.2 uc291rgf.1 uc291rgf.2 
ENSMUST00000207456.2 Gm44999 ENSMUST00000207456.2 Gm44999 (from geneSymbol) ENSMUST00000207456.1 uc291xpj.1 uc291xpj.2 uc291xpj.1 uc291xpj.2 
ENSMUST00000207466.2 4930513N20Rik ENSMUST00000207466.2 4930513N20Rik (from geneSymbol) ENSMUST00000207466.1 LF196639 uc291wgj.1 uc291wgj.2 uc291wgj.1 uc291wgj.2 
ENSMUST00000207473.3 Gm45144 ENSMUST00000207473.3 Gm45144 (from geneSymbol) ENSMUST00000207473.1 ENSMUST00000207473.2 uc291slh.1 uc291slh.2 uc291slh.3 uc291slh.1 uc291slh.2 uc291slh.3 
ENSMUST00000207477.2 Myo16 ENSMUST00000207477.2 myosin XVI (from RefSeq NM_001319151.1) B2RX94 E1CB68 ENSMUST00000207477.1 Kiaa0865 MYO16_MOUSE Myo16 NM_001319151 Nyap3 Q5DU14 Q6GQW7 Q8BUV4 uc009kus.1 uc009kus.2 uc009kus.3 uc009kus.4 uc009kus.5 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development (By similarity). Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. Binds PPP1CA and/or PPP1CC. Binds F-actin in an ATP-sensitive manner (By similarity). Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (PubMed:21946561). Interacts with KIRREL3 (By similarity). Q5DU14; P28660: Nckap1; NbExp=2; IntAct=EBI-7448308, EBI-771576; Cytoplasm Note=Found in puncta in soma and processes of astrocytes and dissociated cerebellar cells with the morphology of migrating granule cells. Event=Alternative splicing; Named isoforms=3; Name=1 ; IsoId=Q5DU14-1; Sequence=Displayed; Name=2 ; IsoId=Q5DU14-2; Sequence=VSP_052446; Name=3; IsoId=Q5DU14-3; Sequence=VSP_042365, VSP_042366; Expressed predominantly in brain where it is present in the neurons, but not in astrocytes or oligodendrites. At postnatal day 1, highly expressed in upper neocortex and also detected in the olfactory bulb, but not in the striatum. Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5. Phosphorylation begins at 14 dpc, reaches a peak during perinatal days in brain, then gradually decreases. Triple knockout mice NYAP1/NYAP2/MYO16 are fertile and appear healthy. However, compared to wild-type mice they show a clear reduction in brain size, exhibiting a reduction in the size of the cortex and striatum, but not the olfactory bulb or corpus callosum. The total neurite length of neurons in these mice is also significantly shorter. In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. In the C-terminal section; belongs to the NYAP family. nucleotide binding motor activity actin binding protein binding ATP binding nucleoplasm cytoplasm cytosol plasma membrane negative regulation of cell proliferation phosphatidylinositol 3-kinase signaling membrane myosin complex cerebellum development macromolecular complex binding perinuclear region of cytoplasm neuron projection morphogenesis actin filament binding negative regulation of G1/S transition of mitotic cell cycle uc009kus.1 uc009kus.2 uc009kus.3 uc009kus.4 uc009kus.5 
ENSMUST00000207479.2 B230206I08Rik ENSMUST00000207479.2 B230206I08Rik (from geneSymbol) AK049623 ENSMUST00000207479.1 uc291sqv.1 uc291sqv.2 uc291sqv.1 uc291sqv.2 
ENSMUST00000207503.2 Gm44741 ENSMUST00000207503.2 Gm44741 (from geneSymbol) AK078620 ENSMUST00000207503.1 uc291qxi.1 uc291qxi.2 uc291qxi.1 uc291qxi.2 
ENSMUST00000207505.2 Gm19410 ENSMUST00000207505.2 predicted gene, 19410 (from RefSeq NM_001370844.1) A0A140LJC7 A0A140LJC7_MOUSE ENSMUST00000207505.1 Gm19410 NM_001370844 uc291zit.1 uc291zit.2 Membrane ; Single- pass type I membrane protein Belongs to the LDLR family. Lacks conserved residue(s) required for the propagation of feature annotation. calcium ion binding membrane integral component of membrane uc291zit.1 uc291zit.2 
ENSMUST00000207510.2 Gm44800 ENSMUST00000207510.2 Gm44800 (from geneSymbol) AK048233 ENSMUST00000207510.1 uc291ybj.1 uc291ybj.2 uc291ybj.1 uc291ybj.2 
ENSMUST00000207515.2 6530437J22Rik ENSMUST00000207515.2 6530437J22Rik (from geneSymbol) AK020101 ENSMUST00000207515.1 uc009gse.1 uc009gse.2 uc009gse.1 uc009gse.2 
ENSMUST00000207517.2 Gm45076 ENSMUST00000207517.2 Gm45076 (from geneSymbol) ENSMUST00000207517.1 uc291yad.1 uc291yad.2 uc291yad.1 uc291yad.2 
ENSMUST00000207526.3 Gm44570 ENSMUST00000207526.3 Gm44570 (from geneSymbol) AK133275 ENSMUST00000207526.1 ENSMUST00000207526.2 uc291rzv.1 uc291rzv.2 uc291rzv.3 uc291rzv.1 uc291rzv.2 uc291rzv.3 
ENSMUST00000207528.2 Gm45066 ENSMUST00000207528.2 Gm45066 (from geneSymbol) ENSMUST00000207528.1 uc291rik.1 uc291rik.2 uc291rik.1 uc291rik.2 
ENSMUST00000207534.3 Gm57854 ENSMUST00000207534.3 predicted gene, 57854 (from RefSeq NM_001419052.1) A0A140LJ28 A0A140LJ28_MOUSE Aldoa ENSMUST00000207534.1 ENSMUST00000207534.2 NM_001419052 uc291vos.1 uc291vos.2 membrane integral component of membrane uc291vos.1 uc291vos.2 
ENSMUST00000207542.3 Or4f14c ENSMUST00000207542.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A140LHX2) A0A140LHX2 A0A140LHX2_MOUSE ENSMUST00000207542.1 ENSMUST00000207542.2 Olfr1315 Or4f14c uc289zgw.1 uc289zgw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zgw.1 uc289zgw.2 
ENSMUST00000207548.3 Gm45133 ENSMUST00000207548.3 Gm45133 (from geneSymbol) ENSMUST00000207548.1 ENSMUST00000207548.2 LF196031 uc291kyk.1 uc291kyk.2 uc291kyk.3 uc291kyk.1 uc291kyk.2 uc291kyk.3 
ENSMUST00000207552.2 Gm10648 ENSMUST00000207552.2 Gm10648 (from geneSymbol) AK158028 ENSMUST00000207552.1 uc291nmy.1 uc291nmy.2 uc291nmy.1 uc291nmy.2 
ENSMUST00000207553.3 Gm39129 ENSMUST00000207553.3 Gm39129 (from geneSymbol) ENSMUST00000207553.1 ENSMUST00000207553.2 uc291yci.1 uc291yci.2 uc291yci.3 uc291yci.1 uc291yci.2 uc291yci.3 
ENSMUST00000207556.2 Gm45185 ENSMUST00000207556.2 Gm45185 (from geneSymbol) AK076744 ENSMUST00000207556.1 uc291syc.1 uc291syc.2 uc291syc.1 uc291syc.2 
ENSMUST00000207560.3 Or4f57 ENSMUST00000207560.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQX0) ENSMUST00000207560.1 ENSMUST00000207560.2 Olfr1308 Olfr1312 Or4f57 Q7TQX0 Q7TQX0_MOUSE uc289zgf.1 uc289zgf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zgf.1 uc289zgf.2 
ENSMUST00000207562.3 Gm44691 ENSMUST00000207562.3 Gm44691 (from geneSymbol) ENSMUST00000207562.1 ENSMUST00000207562.2 uc291rgl.1 uc291rgl.2 uc291rgl.3 uc291rgl.1 uc291rgl.2 uc291rgl.3 
ENSMUST00000207565.2 2200002J24Rik ENSMUST00000207565.2 RIKEN cDNA 2200002J24 gene (from RefSeq NM_026961.2) 2200002J24Rik ENSMUST00000207565.1 NM_026961 Q9D807 Q9D807_MOUSE uc009gfw.1 uc009gfw.2 uc009gfw.3 Belongs to the CD225/Dispanin family. membrane integral component of membrane uc009gfw.1 uc009gfw.2 uc009gfw.3 
ENSMUST00000207573.2 Gm44927 ENSMUST00000207573.2 Gm44927 (from geneSymbol) AK138557 ENSMUST00000207573.1 uc291skr.1 uc291skr.2 uc291skr.1 uc291skr.2 
ENSMUST00000207574.2 Gm45130 ENSMUST00000207574.2 Gm45130 (from geneSymbol) AK043626 ENSMUST00000207574.1 uc291sqm.1 uc291sqm.2 uc291sqm.1 uc291sqm.2 
ENSMUST00000207575.3 Gm45030 ENSMUST00000207575.3 Gm45030 (from geneSymbol) AK044680 ENSMUST00000207575.1 ENSMUST00000207575.2 uc289foa.1 uc289foa.2 uc289foa.1 uc289foa.2 
ENSMUST00000207576.2 Nkpd1 ENSMUST00000207576.2 NTPase, KAP family P-loop domain containing 1, transcript variant 1 (from RefSeq NM_027116.2) ENSMUST00000207576.1 H7BX48 H7BX48_MOUSE NM_027116 Nkpd1 uc291mkj.1 uc291mkj.2 membrane integral component of membrane uc291mkj.1 uc291mkj.2 
ENSMUST00000207577.2 Gm45718 ENSMUST00000207577.2 Gm45718 (from geneSymbol) AK047563 ENSMUST00000207577.1 uc291rxx.1 uc291rxx.2 uc291rxx.1 uc291rxx.2 
ENSMUST00000207579.2 Gm45182 ENSMUST00000207579.2 Gm45182 (from geneSymbol) AK078252 ENSMUST00000207579.1 uc291spx.1 uc291spx.2 uc291spx.1 uc291spx.2 
ENSMUST00000207590.4 Or4k51 ENSMUST00000207590.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGE7) ENSMUST00000207590.1 ENSMUST00000207590.2 ENSMUST00000207590.3 Olfr1301 Or4k51 Q8VGE7 Q8VGE7_MOUSE uc289zfs.1 uc289zfs.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zfs.1 uc289zfs.2 
ENSMUST00000207592.2 Gm45188 ENSMUST00000207592.2 Gm45188 (from geneSymbol) AK085632 ENSMUST00000207592.1 uc009ila.1 uc009ila.2 uc009ila.1 uc009ila.2 
ENSMUST00000207593.2 4930567K12Rik ENSMUST00000207593.2 RIKEN cDNA 4930567K12 gene (from RefSeq NR_131016.1) ENSMUST00000207593.1 NR_131016 uc057aii.1 uc057aii.2 uc057aii.1 uc057aii.2 
ENSMUST00000207600.2 Gm31024 ENSMUST00000207600.2 Gm31024 (from geneSymbol) ENSMUST00000207600.1 uc291nir.1 uc291nir.2 uc291nir.1 uc291nir.2 
ENSMUST00000207605.3 Gm44788 ENSMUST00000207605.3 Gm44788 (from geneSymbol) ENSMUST00000207605.1 ENSMUST00000207605.2 uc291ybz.1 uc291ybz.2 uc291ybz.3 uc291ybz.1 uc291ybz.2 uc291ybz.3 
ENSMUST00000207606.2 Gm45163 ENSMUST00000207606.2 Gm45163 (from geneSymbol) ENSMUST00000207606.1 uc291ytt.1 uc291ytt.2 uc291ytt.1 uc291ytt.2 
ENSMUST00000207613.2 Gm44863 ENSMUST00000207613.2 Gm44863 (from geneSymbol) AK032165 ENSMUST00000207613.1 uc291ldn.1 uc291ldn.2 uc291ldn.1 uc291ldn.2 
ENSMUST00000207620.2 Gm45011 ENSMUST00000207620.2 Gm45011 (from geneSymbol) AK143747 ENSMUST00000207620.1 uc291nix.1 uc291nix.2 uc291nix.1 uc291nix.2 
ENSMUST00000207625.2 A930030B08Rik ENSMUST00000207625.2 A930030B08Rik (from geneSymbol) ENSMUST00000207625.1 uc291taz.1 uc291taz.2 uc291taz.1 uc291taz.2 
ENSMUST00000207632.2 Gm44667 ENSMUST00000207632.2 Gm44667 (from geneSymbol) ENSMUST00000207632.1 uc291rdp.1 uc291rdp.2 uc291rdp.1 uc291rdp.2 
ENSMUST00000207633.2 Gm6176 ENSMUST00000207633.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; (from UniProt J3QK59) BC147388 ENSMUST00000207633.1 Gm6176 J3QK59 J3QK59_MOUSE uc012fdp.1 uc012fdp.2 uc012fdp.3 uc012fdp.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. nucleotide binding microtubule cytoskeleton organization protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm protein phosphorylation intracellular signal transduction tau-protein kinase activity uc012fdp.1 uc012fdp.2 uc012fdp.3 uc012fdp.4 
ENSMUST00000207639.2 Gm44799 ENSMUST00000207639.2 Gm44799 (from geneSymbol) ENSMUST00000207639.1 uc291ybm.1 uc291ybm.2 uc291ybm.1 uc291ybm.2 
ENSMUST00000207640.2 Gm45199 ENSMUST00000207640.2 Gm45199 (from geneSymbol) AK158524 ENSMUST00000207640.1 uc291srl.1 uc291srl.2 uc291srl.1 uc291srl.2 
ENSMUST00000207644.2 Gm44801 ENSMUST00000207644.2 Gm44801 (from geneSymbol) AK140025 ENSMUST00000207644.1 uc291ybk.1 uc291ybk.2 uc291ybk.1 uc291ybk.2 
ENSMUST00000207648.2 Gm44826 ENSMUST00000207648.2 Gm44826 (from geneSymbol) AK029739 ENSMUST00000207648.1 uc291seg.1 uc291seg.2 uc291seg.1 uc291seg.2 
ENSMUST00000207649.2 Gm44709 ENSMUST00000207649.2 Gm44709 (from geneSymbol) ENSMUST00000207649.1 uc291njh.1 uc291njh.2 uc291njh.1 uc291njh.2 
ENSMUST00000207651.2 Gm45047 ENSMUST00000207651.2 Gm45047 (from geneSymbol) AK200592 ENSMUST00000207651.1 uc291vbi.1 uc291vbi.2 uc291vbi.1 uc291vbi.2 
ENSMUST00000207652.3 Gm44968 ENSMUST00000207652.3 Gm44968 (from geneSymbol) ENSMUST00000207652.1 ENSMUST00000207652.2 uc291ryo.1 uc291ryo.2 uc291ryo.3 uc291ryo.1 uc291ryo.2 uc291ryo.3 
ENSMUST00000207657.2 Gm45014 ENSMUST00000207657.2 Gm45014 (from geneSymbol) ENSMUST00000207657.1 uc291sar.1 uc291sar.2 uc291sar.1 uc291sar.2 
ENSMUST00000207661.2 Gm34664 ENSMUST00000207661.2 Gm34664 (from geneSymbol) ENSMUST00000207661.1 uc291rgg.1 uc291rgg.2 uc291rgg.1 uc291rgg.2 
ENSMUST00000207667.2 Gm44830 ENSMUST00000207667.2 Gm44830 (from geneSymbol) ENSMUST00000207667.1 LF204624 uc291qnc.1 uc291qnc.2 uc291qnc.1 uc291qnc.2 
ENSMUST00000207669.2 Tex51 ENSMUST00000207669.2 testis expressed 51 (from RefSeq NM_001370869.1) A0A140LIV7 A0A140LIV7_MOUSE ENSMUST00000207669.1 Gm35060 NM_001370869 Tex51 uc289oon.1 uc289oon.2 membrane integral component of membrane uc289oon.1 uc289oon.2 
ENSMUST00000207673.4 Or5h19 ENSMUST00000207673.4 olfactory receptor family 5 subfamily H member 19 (from RefSeq NM_146322.2) E9QNM5 E9QNM5_MOUSE ENSMUST00000207673.1 ENSMUST00000207673.2 ENSMUST00000207673.3 NM_146322 Olfr187 Olfr196 Or5h19 uc007zon.1 uc007zon.2 uc007zon.3 uc007zon.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB174227.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007zon.1 uc007zon.2 uc007zon.3 uc007zon.4 
ENSMUST00000207674.3 Gm44889 ENSMUST00000207674.3 Gm44889 (from geneSymbol) ENSMUST00000207674.1 ENSMUST00000207674.2 uc291rft.1 uc291rft.2 uc291rft.3 uc291rft.1 uc291rft.2 uc291rft.3 
ENSMUST00000207681.4 Or4d10b ENSMUST00000207681.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFV1) ENSMUST00000207681.1 ENSMUST00000207681.2 ENSMUST00000207681.3 F7CNV2 Olfr1424 Olfr1425 Or4d10b Q8VFV1 Q8VFV1_MOUSE uc289ran.1 uc289ran.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ran.1 uc289ran.2 
ENSMUST00000207684.2 Gdf1 ENSMUST00000207684.2 growth differentiation factor 1, transcript variant 2 (from RefSeq NM_008107.4) ENSMUST00000207684.1 GDF1_MOUSE Gdf-1 NM_008107 P20863 Q6AXH1 uc292aoh.1 uc292aoh.2 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is translated from a monocistronic mRNA early in development, and from a bicistronic mRNA in later stages that also encodes ceramide synthase 1. [provided by RefSeq, Jul 2016]. May mediate cell differentiation events during embryonic development. Homodimer; disulfide-linked. Secreted. Expressed almost exclusively in the nervous system. This protein is produced by a bicistronic gene which also produces the CERS1 protein from a non-overlapping reading frame. Belongs to the TGF-beta family. in utero embryonic development cytokine activity transforming growth factor beta receptor binding extracellular region extracellular space signal transduction endoderm development mesoderm development growth factor activity positive regulation of pathway-restricted SMAD protein phosphorylation BMP signaling pathway regulation of apoptotic process regulation of MAPK cascade cell development SMAD protein signal transduction uc292aoh.1 uc292aoh.2 
ENSMUST00000207688.2 Gm45073 ENSMUST00000207688.2 Gm45073 (from geneSymbol) ENSMUST00000207688.1 uc291yan.1 uc291yan.2 uc291yan.1 uc291yan.2 
ENSMUST00000207692.2 Gm39117 ENSMUST00000207692.2 Gm39117 (from geneSymbol) ENSMUST00000207692.1 uc291xkt.1 uc291xkt.2 uc291xkt.1 uc291xkt.2 
ENSMUST00000207696.2 Gm45176 ENSMUST00000207696.2 Gm45176 (from geneSymbol) ENSMUST00000207696.1 uc291spv.1 uc291spv.2 uc291spv.1 uc291spv.2 
ENSMUST00000207697.2 Gm45187 ENSMUST00000207697.2 Gm45187 (from geneSymbol) AK031221 ENSMUST00000207697.1 uc009ilc.1 uc009ilc.2 uc009ilc.1 uc009ilc.2 
ENSMUST00000207700.2 Gm45841 ENSMUST00000207700.2 Gm45841 (from geneSymbol) AK179630 ENSMUST00000207700.1 uc291lal.1 uc291lal.2 uc291lal.1 uc291lal.2 
ENSMUST00000207705.2 Gm44937 ENSMUST00000207705.2 Gm44937 (from geneSymbol) ENSMUST00000207705.1 uc291qmd.1 uc291qmd.2 uc291qmd.1 uc291qmd.2 
ENSMUST00000207710.3 Or5bb10 ENSMUST00000207710.3 olfactory receptor family 5 subfamily BB member 10 (from RefSeq NM_001011788.1) A0A140LHS7 A0A140LHS7_MOUSE ENSMUST00000207710.1 ENSMUST00000207710.2 NM_001011788 Olfr1432 Or5bb10 uc056zhr.1 uc056zhr.2 uc056zhr.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc056zhr.1 uc056zhr.2 uc056zhr.3 
ENSMUST00000207720.2 Gm20125 ENSMUST00000207720.2 Gm20125 (from geneSymbol) AK029503 ENSMUST00000207720.1 uc287psp.1 uc287psp.2 uc287psp.1 uc287psp.2 
ENSMUST00000207723.2 Gm44532 ENSMUST00000207723.2 Gm44532 (from geneSymbol) BC044747 ENSMUST00000207723.1 uc291rho.1 uc291rho.2 uc291rho.1 uc291rho.2 
ENSMUST00000207742.2 Gm45040 ENSMUST00000207742.2 Gm45040 (from geneSymbol) ENSMUST00000207742.1 uc291ufe.1 uc291ufe.2 uc291ufe.1 uc291ufe.2 
ENSMUST00000207744.2 Gm45178 ENSMUST00000207744.2 Gm45178 (from geneSymbol) ENSMUST00000207744.1 LF196435 uc291spp.1 uc291spp.2 uc291spp.1 uc291spp.2 
ENSMUST00000207750.2 Akap13 ENSMUST00000207750.2 Akap13 (from geneSymbol) A0A140LJJ5 A0A140LJJ5_MOUSE AY033771 Akap13 ENSMUST00000207750.1 uc009hwr.1 uc009hwr.2 uc009hwr.3 cAMP-dependent protein kinase activity Rho guanyl-nucleotide exchange factor activity protein phosphorylation regulation of Rho protein signal transduction intracellular signal transduction metal ion binding uc009hwr.1 uc009hwr.2 uc009hwr.3 
ENSMUST00000207754.2 Cfap99 ENSMUST00000207754.2 cilia and flagella associated protein 99 (from RefSeq NM_001370805.1) A0A140LIX9 A0A140LIX9_MOUSE Cfap99 ENSMUST00000207754.1 NM_001370805 uc290uqi.1 uc290uqi.2 uc290uqi.1 uc290uqi.2 
ENSMUST00000207756.2 Gm44697 ENSMUST00000207756.2 Gm44697 (from geneSymbol) ENSMUST00000207756.1 uc291lec.1 uc291lec.2 uc291lec.1 uc291lec.2 
ENSMUST00000207760.3 Gm38405 ENSMUST00000207760.3 Gm38405 (from geneSymbol) AK040058 ENSMUST00000207760.1 ENSMUST00000207760.2 uc009imf.1 uc009imf.2 uc009imf.3 uc009imf.1 uc009imf.2 uc009imf.3 
ENSMUST00000207761.4 4930431P19Rik ENSMUST00000207761.4 RIKEN cDNA 4930431P19 gene (from RefSeq NR_183171.1) ENSMUST00000207761.1 ENSMUST00000207761.2 ENSMUST00000207761.3 NR_183171 uc009jee.1 uc009jee.2 uc009jee.3 uc009jee.4 uc009jee.5 uc009jee.1 uc009jee.2 uc009jee.3 uc009jee.4 uc009jee.5 
ENSMUST00000207763.2 Gm45165 ENSMUST00000207763.2 Gm45165 (from geneSymbol) AK078377 ENSMUST00000207763.1 uc291yto.1 uc291yto.2 uc291yto.1 uc291yto.2 
ENSMUST00000207771.3 Or10al4 ENSMUST00000207771.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRJ4) ENSMUST00000207771.1 ENSMUST00000207771.2 Olfr120 Or10al4 Q7TRJ4 Q7TRJ4_MOUSE uc289lan.1 uc289lan.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lan.1 uc289lan.2 
ENSMUST00000207772.3 Or5h27 ENSMUST00000207772.3 Or5h27 (from geneSymbol) ENSMUST00000207772.1 ENSMUST00000207772.2 uc057kvp.1 uc057kvp.2 uc057kvp.3 uc057kvp.1 uc057kvp.2 uc057kvp.3 
ENSMUST00000207774.2 Gm44669 ENSMUST00000207774.2 Gm44669 (from geneSymbol) AK033287 ENSMUST00000207774.1 uc291res.1 uc291res.2 uc291res.1 uc291res.2 
ENSMUST00000207792.3 Tnfsf13b ENSMUST00000207792.3 tumor necrosis factor (ligand) superfamily, member 13b, transcript variant 1 (from RefSeq NM_033622.3) Baff ENSMUST00000207792.1 ENSMUST00000207792.2 NM_033622 Q7TQ58 Q9WU72 TN13B_MOUSE uc009kup.1 uc009kup.2 uc009kup.3 uc009kup.4 Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T- cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B- cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Homotrimer. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. Cell membrane; Single-pass type II membrane protein. [Tumor necrosis factor ligand superfamily member 13b, soluble form]: Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WU72-1; Sequence=Displayed; Name=2; Synonyms=DeltaBAFF; IsoId=Q9WU72-2; Sequence=VSP_041184; Isoform 2 is expressed in many myeloid cell lines. The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. Belongs to the tumor necrosis factor family. B cell homeostasis positive regulation of germinal center formation cytokine activity tumor necrosis factor receptor binding extracellular region extracellular space cytoplasm plasma membrane immune response signal transduction membrane integral component of membrane positive regulation of B cell proliferation T cell costimulation B cell costimulation positive regulation of T cell proliferation immunoglobulin secretion perinuclear region of cytoplasm regulation of immune response uc009kup.1 uc009kup.2 uc009kup.3 uc009kup.4 
ENSMUST00000207793.2 Gm44547 ENSMUST00000207793.2 Gm44547 (from geneSymbol) ENSMUST00000207793.1 uc291wiz.1 uc291wiz.2 uc291wiz.1 uc291wiz.2 
ENSMUST00000207795.2 Gm45792 ENSMUST00000207795.2 Gm45792 (from geneSymbol) AK143883 ENSMUST00000207795.1 uc291uxv.1 uc291uxv.2 uc291uxv.1 uc291uxv.2 
ENSMUST00000207806.2 2210406H18Rik ENSMUST00000207806.2 2210406H18Rik (from geneSymbol) AK008836 ENSMUST00000207806.1 uc291vca.1 uc291vca.2 uc291vca.1 uc291vca.2 
ENSMUST00000207808.2 Gm44848 ENSMUST00000207808.2 Gm44848 (from geneSymbol) AK033883 ENSMUST00000207808.1 uc291sks.1 uc291sks.2 uc291sks.1 uc291sks.2 
ENSMUST00000207816.2 Gm44560 ENSMUST00000207816.2 Gm44560 (from geneSymbol) AK038900 ENSMUST00000207816.1 uc009hel.1 uc009hel.2 uc009hel.3 uc009hel.4 uc009hel.5 uc009hel.1 uc009hel.2 uc009hel.3 uc009hel.4 uc009hel.5 
ENSMUST00000207818.2 4933436H12Rik ENSMUST00000207818.2 4933436H12Rik (from geneSymbol) AK017082 ENSMUST00000207818.1 uc291rfw.1 uc291rfw.2 uc291rfw.1 uc291rfw.2 
ENSMUST00000207822.2 Gm45221 ENSMUST00000207822.2 Gm45221 (from geneSymbol) ENSMUST00000207822.1 uc291snv.1 uc291snv.2 uc291snv.1 uc291snv.2 
ENSMUST00000207826.2 Zfp654 ENSMUST00000207826.2 zinc finger protein 654 (from RefSeq NM_001347245.1) A0A140LI34 ENSMUST00000207826.1 NM_001347245 Q8K390 Q9DAU9 ZN654_MOUSE Znf654 uc057kvs.1 uc057kvs.2 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAH27760.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH68018.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAB24088.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function nucleic acid binding DNA binding cellular_component nucleus biological_process metal ion binding uc057kvs.1 uc057kvs.2 
ENSMUST00000207828.2 Gm44678 ENSMUST00000207828.2 Gm44678 (from geneSymbol) AK032478 ENSMUST00000207828.1 uc291sqa.1 uc291sqa.2 uc291sqa.1 uc291sqa.2 
ENSMUST00000207829.2 Gm44969 ENSMUST00000207829.2 Gm44969 (from geneSymbol) AK033058 ENSMUST00000207829.1 uc009had.1 uc009had.2 uc009had.1 uc009had.2 
ENSMUST00000207830.2 Gm44755 ENSMUST00000207830.2 Gm44755 (from geneSymbol) AK156918 ENSMUST00000207830.1 uc291rda.1 uc291rda.2 uc291rda.1 uc291rda.2 
ENSMUST00000207836.3 Or10q1 ENSMUST00000207836.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGP8) ENSMUST00000207836.1 ENSMUST00000207836.2 Olfr1491 Olfr1494 Or10q1 Q8VGP8 Q8VGP8_MOUSE uc289rgr.1 uc289rgr.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rgr.1 uc289rgr.2 
ENSMUST00000207837.2 Gm44541 ENSMUST00000207837.2 Gm44541 (from geneSymbol) ENSMUST00000207837.1 uc291ybd.1 uc291ybd.2 uc291ybd.1 uc291ybd.2 
ENSMUST00000207838.2 Gm44625 ENSMUST00000207838.2 Gm44625 (from geneSymbol) ENSMUST00000207838.1 uc057ajt.1 uc057ajt.2 uc057ajt.1 uc057ajt.2 
ENSMUST00000207840.2 C030038I04Rik ENSMUST00000207840.2 C030038I04Rik (from geneSymbol) AK021131 ENSMUST00000207840.1 uc291sqj.1 uc291sqj.2 uc291sqj.1 uc291sqj.2 
ENSMUST00000207844.2 4931412I15Rik ENSMUST00000207844.2 4931412I15Rik (from geneSymbol) AK016451 ENSMUST00000207844.1 uc291sqp.1 uc291sqp.2 uc291sqp.1 uc291sqp.2 
ENSMUST00000207847.2 Gm45220 ENSMUST00000207847.2 Gm45220 (from geneSymbol) ENSMUST00000207847.1 uc291snz.1 uc291snz.2 uc291snz.1 uc291snz.2 
ENSMUST00000207854.2 Ttc34 ENSMUST00000207854.2 tetratricopeptide repeat domain 34 (from RefSeq NM_172878.4) A0A140LHH0 A0A140LHH0_MOUSE ENSMUST00000207854.1 NM_172878 Ttc34 uc290siq.1 uc290siq.2 uc290siq.1 uc290siq.2 
ENSMUST00000207856.2 Gm29797 ENSMUST00000207856.2 predicted gene, 29797 (from RefSeq NM_001377050.1) A0A140LIA7 CT204_MOUSE ENSMUST00000207856.1 Gm29797 NM_001377050 uc290dpw.1 uc290dpw.2 uc290dpw.1 uc290dpw.2 
ENSMUST00000207859.2 Gm35842 ENSMUST00000207859.2 Gm35842 (from geneSymbol) ENSMUST00000207859.1 uc291rhr.1 uc291rhr.2 uc291rhr.1 uc291rhr.2 
ENSMUST00000207871.2 BC048679 ENSMUST00000207871.2 cDNA sequence BC048679, transcript variant 3 (from RefSeq NM_001358040.1) A0A140LJ97 A0A140LJ97_MOUSE BC048679 ENSMUST00000207871.1 NM_001358040 uc012fnw.1 uc012fnw.2 uc012fnw.3 molecular_function cellular_component biological_process uc012fnw.1 uc012fnw.2 uc012fnw.3 
ENSMUST00000207873.2 Zfp14 ENSMUST00000207873.2 zinc finger protein 14, transcript variant 2 (from RefSeq NM_178733.5) ENSMUST00000207873.1 Kiaa1559 Krox-9 NM_178733 P10755 Q5DTW6 Q8BFZ5 ZFP14_MOUSE Zfp-14 uc009gcx.1 uc009gcx.2 uc009gcx.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAD90454.1; Type=Erroneous initiation; Evidence=; blastocyst hatching nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009gcx.1 uc009gcx.2 uc009gcx.3 
ENSMUST00000207874.2 Pgpep1l ENSMUST00000207874.2 Belongs to the peptidase C15 family. (from UniProt A0A140LIX6) A0A140LIX6 A0A140LIX6_MOUSE AK021221 ENSMUST00000207874.1 Pgpep1l uc291rfi.1 uc291rfi.2 Belongs to the peptidase C15 family. cytosol proteolysis pyroglutamyl-peptidase activity uc291rfi.1 uc291rfi.2 
ENSMUST00000207878.2 Gm45181 ENSMUST00000207878.2 Gm45181 (from geneSymbol) ENSMUST00000207878.1 uc291xrg.1 uc291xrg.2 uc291xrg.1 uc291xrg.2 
ENSMUST00000207881.2 Gm4513 ENSMUST00000207881.2 predicted gene 4513 (from RefSeq NM_001324551.1) A0A140LJ87 A0A140LJ87_MOUSE ENSMUST00000207881.1 Gm4513 Gm4565 NM_001324551 uc057ltd.1 uc057ltd.2 uc057ltd.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. nucleotide binding microtubule cytoskeleton organization protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm protein phosphorylation intracellular signal transduction tau-protein kinase activity uc057ltd.1 uc057ltd.2 uc057ltd.3 
ENSMUST00000207898.2 Gm44926 ENSMUST00000207898.2 Gm44926 (from geneSymbol) AK048001 ENSMUST00000207898.1 uc291skq.1 uc291skq.2 uc291skq.1 uc291skq.2 
ENSMUST00000207900.2 Gm45793 ENSMUST00000207900.2 Gm45793 (from geneSymbol) AK046072 ENSMUST00000207900.1 uc291smn.1 uc291smn.2 uc291smn.1 uc291smn.2 
ENSMUST00000207901.2 Zfp524 ENSMUST00000207901.2 zinc finger protein 524, transcript variant 4 (from RefSeq NM_001418683.1) ENSMUST00000207901.1 NM_001418683 Q9D0B1 Q9DCQ0 ZN524_MOUSE Znf524 uc033iwg.1 uc033iwg.2 uc033iwg.3 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=BAB22215.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding nucleus metal ion binding uc033iwg.1 uc033iwg.2 uc033iwg.3 
ENSMUST00000207911.2 Gm44668 ENSMUST00000207911.2 Gm44668 (from geneSymbol) ENSMUST00000207911.1 uc291rds.1 uc291rds.2 uc291rds.1 uc291rds.2 
ENSMUST00000207912.2 4930405G09Rik ENSMUST00000207912.2 4930405G09Rik (from geneSymbol) AK015097 ENSMUST00000207912.1 uc291rfn.1 uc291rfn.2 uc291rfn.1 uc291rfn.2 
ENSMUST00000207913.2 Ccdc194 ENSMUST00000207913.2 coiled-coil domain containing 194 (from RefSeq NM_001370849.1) A0A140LIT1 CC194_MOUSE Ccdc194 ENSMUST00000207913.1 NM_001370849 uc009mdq.1 uc009mdq.2 uc009mdq.3 uc009mdq.1 uc009mdq.2 uc009mdq.3 
ENSMUST00000207917.2 Kcnb1 ENSMUST00000207917.2 potassium voltage gated channel, Shab-related subfamily, member 1 (from RefSeq NM_008420.4) ENSMUST00000207917.1 KCNB1_MOUSE Kcnb1 NM_008420 Q03717 Q8K0D1 uc008nzh.1 uc008nzh.2 uc008nzh.3 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:14684365, PubMed:19383458, PubMed:24494598). Also plays a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:22056818). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (By similarity). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits, such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (PubMed:22056818). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle (PubMed:10506487, PubMed:12270920, PubMed:17767909, PubMed:23161216, PubMed:24494598). Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation (By similarity). Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (PubMed:24494598). Contributes to the regulation of the glucose-induced amplitude and duration of action potentials in pancreatic beta-cells, hence limiting calcium influx and insulin secretion (PubMed:12270920, PubMed:17767909, PubMed:19383458, PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells (By similarity). May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval (PubMed:10506487, PubMed:14684365). Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury (By similarity). May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (By similarity). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity). Inhibited by 42 nM hanatoxin 1 (HaTx1), a spider venom toxin of the tarantula G.spatulata. Inhibited by 100 nM stromatoxin 1 (ScTx1), a spider venom toxin of the tarantula S.calceata (By similarity). Modestly sensitive to millimolar levels of tetraethylammonium (TEA) and 4-aminopyridine (4-AP) (PubMed:2002364, PubMed:10414301, PubMed:15858231). Completely insensitive to toxins such as dendrotoxin (DTX) and charybdotoxin (CTX) (By similarity). Kinetic parameters: Note=Homotetrameric channels expressed in xenopus oocytes or in mammalian non-neuronal cells display delayed-rectifier voltage- dependent potassium currents which are activated during membrane depolarization, i.e within a risetime of more than 20 msec (PubMed:2002364). After that, inactivate very slowly, i.e within more than 5 sec (PubMed:2002364). Their activation requires low threshold potentials at about -20 to -30 mV with a midpoint activation at about 10 mV. For inactivation, the voltage at half-maximal amplitude is about -20 mV. The time constant for recovery after inactivation is about 1.6 sec. Channels have an unitary conductance of about 8 pS. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system, the presence or absence of ancillary subunits and post-translational modifications. Homotetramer or heterotetramer with KCNB2. Heterotetramer with non-conducting channel-forming alpha subunits such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1 (By similarity). Channel activity is regulated by association with ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3 (PubMed:22056818). Interacts with KCNV2 (By similarity). Self- associates (via N-terminus and C-terminus); self-association is required to regulate trafficking, gating and C-terminal phosphorylation-dependent modulation of the channel. Interacts (via C- terminus) with STX1A (via C-terminus); this decreases the rate of channel activation and increases the rate of channel inactivation in pancreatic beta cells, induces also neuronal apoptosis in response to oxidative injury as well as pore-independent enhancement of exocytosis in neuroendocrine cells, chromaffin cells, pancreatic beta cells and from the soma of dorsal root ganglia (DRG) neurons. Interacts (via N- terminus) with SNAP25; this decreases the rate of channel inactivation in pancreatic beta cells and also increases interaction during neuronal apoptosis in a N-methyl-D-aspartate receptor (NMDAR)-dependent manner. Interacts (via N-terminus and C-terminus) with VAMP2 (via N-terminus); stimulates channel inactivation rate. Interacts with CREB1; this promotes channel acetylation in response to stimulation by incretin hormones. Interacts (via N-terminus and C-terminus) with MYL12B. Interacts (via N-terminus) with PIAS3; this increases the number of functional channels at the cell surface. Interacts with SUMO1 (By similarity). Interacts (via phosphorylated form) with PTPRE isoform 2; this reduces phosphorylation and channel activity in heterologous cells (PubMed:10921884). Interacts (via phosphorylated FFAT motif) with VAPA and VAPB (By similarity). Q03717; Q80ZD8: Amigo1; NbExp=4; IntAct=EBI-7511364, EBI-7511393; Cell membrane rikaryon Cell projection, axon Cell projection, dendrite Membrane; Multi-pass membrane protein. Postsynaptic cell membrane Synapse Synapse, synaptosome Lateral cell membrane Cell membrane, sarcolemma Note=Localizes to high-density somatodendritic clusters and non-clustered sites on the surface of neocortical and hippocampal pyramidal neurons in a cortical actin cytoskeleton-dependent manner (PubMed:24477962). Localizes also to high-density clusters in the axon initial segment (AIS), at ankyrin-G- deficient sites, on the surface of neocortical and hippocampal pyramidal neurons (PubMed:24477962). KCNB1-containing AIS clusters localize either in close apposition to smooth endoplasmic reticulum cisternal organelles or with GABA-A receptor-containing synapses of hippocampal and cortical pyramidal neurons, respectively (PubMed:24477962). Localizes to high-density clusters on the cell surface of atrial and ventricular myocytes and at the lateral plasma membrane in epithelial cells. Localizes both to the axial and transverse tubules (T tubule) and sarcolemma in ventricular myocytes. Associated with lipid raft domains. In cortical neurons, apoptotic injuries induce de novo plasma membrane insertion in a SNARE-dependent manner causing an apoptotic potassium current surge (By similarity). Expressed in the brain (PubMed:17767909, PubMed:22056818). Expressed in the heart (PubMed:14684365). Expressed in pyramidal neurons and interneurons of the hippocampus (PubMed:22056818, PubMed:24494598). Expressed in neocortical pyramidal neurons (PubMed:22056818, PubMed:24477962). Expressed in dorsal root ganglia (DRG) neurons (PubMed:19357235). Expressed in pancreatic beta cells (PubMed:12270920, PubMed:17767909). Expressed in Schwann cells (PubMed:10921884). Expressed in ventricular myocytes (at protein level) (PubMed:14684365, PubMed:10506487). The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. The N-terminal and C-terminal cytoplasmic regions mediate homooligomerization; self-association is required to regulate trafficking, gating and C-terminal phosphorylation-dependent modulation of the channel (By similarity). The N-terminal cytoplasmic region is important for interaction with other channel-forming alpha subunits and with ancillary beta subunits (PubMed:22056818). The C-terminus is necessary and sufficient for the restricted localization to, and clustering within, both in soma and proximal portions of dendrite of neurons and in lateral membrane of non-neuronal polarized cells. The C- terminus is both necessary and sufficient as a mediator of cholinergic and calcium-stimulated modulation of channel cell membrane clustering localization and activity in hippocampal neurons (By similarity). The FFAT motif is involved in the interaction with VAPA and VAPB and its phosphorylation regulates these interactions. Phosphorylated. Differential C-terminal phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating in hippocampal neurons. Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/dephosphorylation activities. Tyr-128 can be phosphorylated by Src and dephosphorylated by cytoplasmic form of the phosphatase PTPRE. CDK5-induced Ser-607 phosphorylation increases in response to acute blockade of neuronal activity. Phosphorylated on Tyr- 128 by Src and on Ser-804 by MAPK14/P38MAPK; phosphorylations are necessary and sufficient for an increase in plasma membrane insertion, apoptotic potassium current surge and completion of the neuronal cell death program. Phosphorylated on Ser-520, Ser-655, Ser-607 and Ser-804 by CDK5; phosphorylation is necessary for KCNB1 channel clustering formation. The Ser-607 phosphorylation state differs between KCNB1- containing clusters on the proximal and distal portions of the axon initial segment (AIS). Highly phosphorylated on serine residues in the C-terminal cytoplasmic tail in resting neurons. Phosphorylated in pancreatic beta cells in response to incretin hormones stimulation in a PKA- and RPS6KA5/MSK1-dependent signaling pathway, promoting beta cell survival. Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5; levels then increase to reach adult levels by P14. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser- 607, Ser-655 and Ser-719 as well as the N-terminal Ser-15 are sensitive to calcineurin-mediated dephosphorylation contributing to the modulation of the voltage-dependent gating properties. Dephosphorylation by phosphatase PTPRE confers neuroprotection by its inhibitory influence on the neuronal apoptotic potassium current surge in a Zn(2+)-dependent manner. Dephosphorylated at Ser-607 by protein phosphatase PPP1CA. Hypoxia-, seizure- or glutamate-induced neuronal activities promote calcium/calcineurin-dependent dephosphorylation resulting in a loss of KCNB1-containing clustering and enhanced channel activity. In response to brain ischemia, Ser-567 and Ser-607 are strongly dephosphorylated while Ser-457 and Ser-719 are less dephosphorylated. In response to brain seizures, phosphorylation levels on Ser-567 and Ser-607 are greatly reduced (By similarity). Phosphorylated/dephosphorylated by Src or FYN tyrosine-protein kinases and tyrosine phosphatase PTPRE in primary Schwann cells and sciatic nerve tissue (PubMed:10921884). Phosphorylation at Ser-593 of the FFAT motif activates interaction with MOSPD2, VAPA and VAPB (By similarity). Acetylated. Acetylation occurs in pancreatic beta cells in response to stimulation by incretin hormones in a histone acetyltransferase (HAT)/histone deacetylase (HDAC)-dependent signaling pathway, promoting beta cell survival. Sumoylated on Lys-474, preferentially with SUMO1; sumoylation induces a positive shift in the voltage-dependence of activation and inhibits channel activity. Sumoylation increases the frequency of repetitive action potential firing at the cell surface of hippocampal neurons and decreases its frequency in pancreatic beta cells. Desumoylated by SENP1. Mice show normal motor coordination and visual acuity, but are hyperactive, exhibit defects in spatial learning ability and show reduced anxiety-like behavior (PubMed:24494598). Show a higher incidence and a shorter latency to seizure progression compared to wild-type mice (PubMed:24494598). Display reduced fasting blood glucose levels and elevated serum insulin levels (PubMed:17767909, PubMed:19383458). Glucose tolerance and insulin secretion is enhanced compared to control animals (PubMed:17767909, PubMed:19383458). Show impaired long-term potentiation in hippocampal neurons (PubMed:24494598). Display a reduction in the slowly deactivating delayed rectifier potassium current in hippocampal pyramidal neurons (PubMed:24494598). Glucose-induced action potential (AP) duration and amplitude is increased while the firing frequency is reduced in pancreatic beta cells (PubMed:17767909, PubMed:19383458). Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily. SNARE binding action potential ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity protein binding endoplasmic reticulum plasma membrane ion transport potassium ion transport exocytosis vesicle docking involved in exocytosis glutamate receptor signaling pathway voltage-gated potassium channel complex cell surface positive regulation of norepinephrine secretion outward rectifier potassium channel activity membrane integral component of membrane lateral plasma membrane cell junction axon dendrite cellular response to nutrient levels dendrite membrane neuronal cell body membrane positive regulation of catecholamine secretion regulation of ion transmembrane transport sarcolemma glucose homeostasis cell projection neuron projection neuronal cell body perikaryon ion channel binding synapse postsynaptic membrane positive regulation of calcium ion-dependent exocytosis negative regulation of insulin secretion protein heterodimerization activity protein N-terminus binding protein oligomerization protein homooligomerization transmembrane transport cellular response to glucose stimulus potassium ion transmembrane transport protein localization to plasma membrane positive regulation of protein targeting to membrane regulation of action potential positive regulation of long term synaptic depression regulation of motor neuron apoptotic process uc008nzh.1 uc008nzh.2 uc008nzh.3 
ENSMUST00000207920.2 Gm44530 ENSMUST00000207920.2 Gm44530 (from geneSymbol) ENSMUST00000207920.1 LF196418 uc291sds.1 uc291sds.2 uc291sds.1 uc291sds.2 
ENSMUST00000207921.2 Gm44813 ENSMUST00000207921.2 Gm44813 (from geneSymbol) ENSMUST00000207921.1 uc291rhs.1 uc291rhs.2 uc291rhs.1 uc291rhs.2 
ENSMUST00000207927.3 Or5ac24 ENSMUST00000207927.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGP9) ENSMUST00000207927.1 ENSMUST00000207927.2 Olfr204 Olfr206 Or5ac24 Q8VGP9 Q8VGP9_MOUSE uc007zpd.1 uc007zpd.2 uc007zpd.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007zpd.1 uc007zpd.2 uc007zpd.3 
ENSMUST00000207932.2 Prss23 ENSMUST00000207932.2 serine protease 23, transcript variant 1 (from RefSeq NM_001360752.2) ENSMUST00000207932.1 NM_001360752 PRS23_MOUSE Q544M8 Q8VEG1 Q9D6X6 uc033jaf.1 uc033jaf.2 uc033jaf.3 Secreted Belongs to the peptidase S1 family. serine-type endopeptidase activity extracellular region extracellular space nucleus proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc033jaf.1 uc033jaf.2 uc033jaf.3 
ENSMUST00000207934.2 Gm44623 ENSMUST00000207934.2 Gm44623 (from geneSymbol) ENSMUST00000207934.1 uc291wia.1 uc291wia.2 uc291wia.1 uc291wia.2 
ENSMUST00000207936.2 5930435M05Rik ENSMUST00000207936.2 5930435M05Rik (from geneSymbol) AK020043 ENSMUST00000207936.1 uc009idl.1 uc009idl.2 uc009idl.1 uc009idl.2 
ENSMUST00000207937.2 Gm45183 ENSMUST00000207937.2 Gm45183 (from geneSymbol) AK043660 ENSMUST00000207937.1 uc291spz.1 uc291spz.2 uc291spz.1 uc291spz.2 
ENSMUST00000207943.2 Gm45015 ENSMUST00000207943.2 Belongs to the PNMA family. (from UniProt A0A140LII9) A0A140LII9 A0A140LII9_MOUSE ENSMUST00000207943.1 Gm45015 uc292oqx.1 uc292oqx.2 Belongs to the PNMA family. uc292oqx.1 uc292oqx.2 
ENSMUST00000207954.2 Gm45719 ENSMUST00000207954.2 Gm45719 (from geneSymbol) AK048503 ENSMUST00000207954.1 uc291wfn.1 uc291wfn.2 uc291wfn.1 uc291wfn.2 
ENSMUST00000207962.3 Gm45194 ENSMUST00000207962.3 testis expressed gene 16, transcript variant 5 (from RefSeq NM_001417277.1) A0A140LJG2 A0A140LJG2_MOUSE ENSMUST00000207962.1 ENSMUST00000207962.2 Gm45194 NM_001417277 uc292qeb.1 uc292qeb.2 uc292qeb.3 uc292qeb.1 uc292qeb.2 uc292qeb.3 
ENSMUST00000207963.2 Gm44827 ENSMUST00000207963.2 predicted gene 44827 (from RefSeq NR_171895.1) ENSMUST00000207963.1 NR_171895 uc291seh.1 uc291seh.2 uc291seh.1 uc291seh.2 
ENSMUST00000207967.2 Gm31343 ENSMUST00000207967.2 Gm31343 (from geneSymbol) AK042586 ENSMUST00000207967.1 uc291yae.1 uc291yae.2 uc291yae.1 uc291yae.2 
ENSMUST00000207969.4 Or5an11 ENSMUST00000207969.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q9Z6) A0A140LHT0 E9Q9Z6 E9Q9Z6_MOUSE ENSMUST00000207969.1 ENSMUST00000207969.2 ENSMUST00000207969.3 Olfr235 Or5an11 uc008gtu.1 uc008gtu.2 uc008gtu.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gtu.1 uc008gtu.2 uc008gtu.3 
ENSMUST00000207973.2 Gm39078 ENSMUST00000207973.2 Gm39078 (from geneSymbol) ENSMUST00000207973.1 uc291uxp.1 uc291uxp.2 uc291uxp.1 uc291uxp.2 
ENSMUST00000207976.4 Or4f61 ENSMUST00000207976.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AVL6) A2AVL6 A2AVL6_MOUSE ENSMUST00000207976.1 ENSMUST00000207976.2 ENSMUST00000207976.3 Olfr1314 Olfr1316 Or4f61 uc289zgv.1 uc289zgv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zgv.1 uc289zgv.2 
ENSMUST00000207981.2 Gm44862 ENSMUST00000207981.2 Gm44862 (from geneSymbol) ENSMUST00000207981.1 uc291ldm.1 uc291ldm.2 uc291ldm.1 uc291ldm.2 
ENSMUST00000207983.2 Homer2 ENSMUST00000207983.2 homer scaffolding protein 2, transcript variant 1 (from RefSeq NM_011983.2) ENSMUST00000207983.1 HOME2_MOUSE Homer2 NM_011983 O89025 Q9QWW1 Q9Z0E4 Vesl2 uc009ich.1 uc009ich.2 uc009ich.3 uc009ich.4 Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity) Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity). Forms coiled-coil structures coiled-coil structures that mediate homo- and heteromultimerization. Interacts with NFATC2; interaction is reduced by AKT activation. Interacts with NFATC1 and NFATC4 (By similarity). Interacts with DAGLA (via PPXXF motif); this interaction is required for the cell membrane localization of DAGLA (By similarity). Cytoplasm Cell membrane Postsynaptic density. Synapse. Cell projection, stereocilium Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=2b; IsoId=Q9QWW1-1; Sequence=Displayed; Name=2; Synonyms=2a; IsoId=Q9QWW1-2; Sequence=VSP_009071; Expressed in olfactory bulb, hippocampus, thalamus and heart (PubMed:9808459). Expressed in the cochlea, organ of Corti. Expression is particularly enriched in the tips of stereocilia of both inner and outer hair cells (PubMed:25816005). Homozygous knockout mice exhibit early onset progressive hearing loss. Belongs to the Homer family. actin binding protein binding cytoplasm plasma membrane G-protein coupled glutamate receptor signaling pathway sensory perception of sound regulation of G-protein coupled receptor protein signaling pathway positive regulation of signal transduction postsynaptic density membrane protein domain specific binding cell junction GKAP/Homer scaffold activity dendrite stereocilium stereocilium tip negative regulation of interleukin-2 production glutamate receptor binding G-protein coupled glutamate receptor binding calcium-mediated signaling using intracellular calcium source protein homodimerization activity cell projection neuron projection neuronal cell body apical part of cell synapse postsynaptic membrane protein heterodimerization activity behavioral response to cocaine chemical homeostasis within a tissue negative regulation of calcineurin-NFAT signaling cascade glutamatergic synapse regulation of store-operated calcium entry uc009ich.1 uc009ich.2 uc009ich.3 uc009ich.4 
ENSMUST00000207997.3 Or5b99 ENSMUST00000207997.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFX5) ENSMUST00000207997.1 ENSMUST00000207997.2 Olfr1451 Or5b99 Q8VFX5 Q8VFX5_MOUSE uc289rdw.1 uc289rdw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rdw.1 uc289rdw.2 
ENSMUST00000208008.2 Gm44829 ENSMUST00000208008.2 Gm44829 (from geneSymbol) ENSMUST00000208008.1 uc291qng.1 uc291qng.2 uc291qng.1 uc291qng.2 
ENSMUST00000208016.2 Gm45235 ENSMUST00000208016.2 Gm45235 (from geneSymbol) ENSMUST00000208016.1 uc291qia.1 uc291qia.2 uc291qia.1 uc291qia.2 
ENSMUST00000208026.2 Gm44802 ENSMUST00000208026.2 Gm44802 (from geneSymbol) AK045452 ENSMUST00000208026.1 uc291ybo.1 uc291ybo.2 uc291ybo.1 uc291ybo.2 
ENSMUST00000208033.3 Gm32916 ENSMUST00000208033.3 predicted gene, 32916 (from RefSeq NM_001395053.1) ENSMUST00000208033.1 ENSMUST00000208033.2 NM_001395053 uc291vac.1 uc291vac.2 uc291vac.3 uc291vac.1 uc291vac.2 uc291vac.3 
ENSMUST00000208039.2 Dhrs7l ENSMUST00000208039.2 Belongs to the short-chain dehydrogenases/reductases (SDR) family. (from UniProt A0A140LIS8) A0A140LIS8 A0A140LIS8_MOUSE Dhrs7l ENSMUST00000208039.1 Gm4756 uc288hcq.1 uc288hcq.2 Belongs to the short-chain dehydrogenases/reductases (SDR) family. uc288hcq.1 uc288hcq.2 
ENSMUST00000208043.2 Pigq ENSMUST00000208043.2 phosphatidylinositol glycan anchor biosynthesis, class Q, transcript variant 5 (from RefSeq NM_001413275.1) ENSMUST00000208043.1 Gpi1h Mgpi1 NM_001413275 O35120 O35456 PIGQ_MOUSE Pigq Q99L11 Q9QYT7 uc289imx.1 uc289imx.2 Part of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Component of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts with PIGA, PIGH and PIGC. Membrane ; Multi-pass membrane protein Belongs to the PIGQ family. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex GPI anchor biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups phosphatidylinositol N-acetylglucosaminyltransferase activity uc289imx.1 uc289imx.2 
ENSMUST00000208049.2 Aurkc ENSMUST00000208049.2 Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. (from UniProt O88445) AF054620 AURKC_MOUSE Aie1 Aik3 Airk3 Ark3 ENSMUST00000208049.1 O88445 Q6P209 Q9JLC2 Stk13 uc009fcf.1 uc009fcf.2 uc009fcf.3 Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Okadaic acid, an inhibitor of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein phosphatase 5 (PP5), increases AURKC activity. AURKC is also stabilized through its interaction with INCENP, which acts also as an activator (By similarity). Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist; in the complex interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1. Nucleus Chromosome Chromosome, centromere Cytoplasm, cytoskeleton, spindle Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis (By similarity). Expressed only in testis. Expressed on day 14 dpc in prepubertal testis, expression reached its plateau on day 21 dpc and remained at a high level in adult. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. nucleotide binding chromosome, centromeric region condensed nuclear chromosome, centromeric region condensed chromosome protein kinase activity protein serine/threonine kinase activity ATP binding nucleus chromosome cytoplasm spindle cytoskeleton spindle microtubule protein phosphorylation cell cycle mitotic spindle organization spermatogenesis kinase activity phosphorylation transferase activity midbody spindle pole centrosome chromosome passenger complex regulation of cytokinesis histone serine kinase activity histone-serine phosphorylation protein autophosphorylation oocyte development spindle midzone spindle midzone assembly cell division meiotic cell cycle meiotic spindle midzone uc009fcf.1 uc009fcf.2 uc009fcf.3 
ENSMUST00000208051.2 Gm45131 ENSMUST00000208051.2 Gm45131 (from geneSymbol) ENSMUST00000208051.1 uc291sqo.1 uc291sqo.2 uc291sqo.1 uc291sqo.2 
ENSMUST00000208055.2 Gm44732 ENSMUST00000208055.2 Gm44732 (from geneSymbol) ENSMUST00000208055.1 uc291xmp.1 uc291xmp.2 uc291xmp.1 uc291xmp.2 
ENSMUST00000208060.2 Gm44913 ENSMUST00000208060.2 Gm44913 (from geneSymbol) ENSMUST00000208060.1 uc291qgm.1 uc291qgm.2 uc291qgm.1 uc291qgm.2 
ENSMUST00000208065.2 4930435N07Rik ENSMUST00000208065.2 4930435N07Rik (from geneSymbol) AK015328 ENSMUST00000208065.1 uc291ybg.1 uc291ybg.2 uc291ybg.1 uc291ybg.2 
ENSMUST00000208080.2 Gm44518 ENSMUST00000208080.2 Gm44518 (from geneSymbol) AK140600 ENSMUST00000208080.1 uc291ybe.1 uc291ybe.2 uc291ybe.1 uc291ybe.2 
ENSMUST00000208082.2 Gm45089 ENSMUST00000208082.2 Gm45089 (from geneSymbol) ENSMUST00000208082.1 uc291sbd.1 uc291sbd.2 uc291sbd.1 uc291sbd.2 
ENSMUST00000208097.2 E230020D15Rik ENSMUST00000208097.2 E230020D15Rik (from geneSymbol) AK085614 ENSMUST00000208097.1 uc291yal.1 uc291yal.2 uc291yal.1 uc291yal.2 
ENSMUST00000208098.2 Gm44928 ENSMUST00000208098.2 Gm44928 (from geneSymbol) ENSMUST00000208098.1 uc291sez.1 uc291sez.2 uc291sez.1 uc291sez.2 
ENSMUST00000208105.2 1700041M19Rik ENSMUST00000208105.2 RIKEN cDNA 1700063K16 gene (from RefSeq NR_170997.1) ENSMUST00000208105.1 NR_170997 uc289foe.1 uc289foe.2 uc289foe.1 uc289foe.2 
ENSMUST00000208123.2 Gm44798 ENSMUST00000208123.2 Gm44798 (from geneSymbol) ENSMUST00000208123.1 uc291ybl.1 uc291ybl.2 uc291ybl.1 uc291ybl.2 
ENSMUST00000208130.2 Frmpd3 ENSMUST00000208130.2 FERM and PDZ domain containing 3, transcript variant 6 (from RefSeq NM_001388458.1) A0A140LIW3 A0A140LIW3_MOUSE ENSMUST00000208130.1 Frmpd3 NM_001388458 uc057cfw.1 uc057cfw.2 molecular_function cellular_component cytoskeleton biological_process uc057cfw.1 uc057cfw.2 
ENSMUST00000208134.2 Gm4565 ENSMUST00000208134.2 predicted gene 4565 (from RefSeq NM_001324552.1) A0A140LJ87 A0A140LJ87_MOUSE ENSMUST00000208134.1 Gm4513 Gm4565 NM_001324552 uc057ltg.1 uc057ltg.2 uc057ltg.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. nucleotide binding microtubule cytoskeleton organization protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm protein phosphorylation intracellular signal transduction tau-protein kinase activity uc057ltg.1 uc057ltg.2 uc057ltg.3 
ENSMUST00000208141.2 Gm44693 ENSMUST00000208141.2 Gm44693 (from geneSymbol) ENSMUST00000208141.1 uc291xzf.1 uc291xzf.2 uc291xzf.1 uc291xzf.2 
ENSMUST00000208147.3 Or6a2 ENSMUST00000208147.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9QWU6) A0A1B0GSD4 ENSMUST00000208147.1 ENSMUST00000208147.2 Olfr2 Or6a2 Q9QWU6 Q9QWU6_MOUSE S73844 uc291udz.1 uc291udz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291udz.1 uc291udz.2 
ENSMUST00000208156.2 Gm45208 ENSMUST00000208156.2 Membrane ulti-pass membrane protein (from UniProt A0A140LJ36) A0A140LJ36 A0A140LJ36_MOUSE AK018409 ENSMUST00000208156.1 Gm45208 uc292myt.1 uc292myt.2 Membrane ulti-pass membrane protein Belongs to the PRA1 family. Belongs to the WD repeat PROPPIN family. autophagosome assembly mitophagy cytosol protein lipidation autophagy membrane integral component of membrane extrinsic component of membrane phosphatidylinositol-3-phosphate binding pre-autophagosomal structure membrane protein localization to pre-autophagosomal structure phosphatidylinositol-3,5-bisphosphate binding uc292myt.1 uc292myt.2 
ENSMUST00000208157.2 Gm44901 ENSMUST00000208157.2 Gm44901 (from geneSymbol) AK028672 ENSMUST00000208157.1 uc291vbz.1 uc291vbz.2 uc291vbz.1 uc291vbz.2 
ENSMUST00000208165.2 Gm44786 ENSMUST00000208165.2 Gm44786 (from geneSymbol) ENSMUST00000208165.1 uc291yce.1 uc291yce.2 uc291yce.1 uc291yce.2 
ENSMUST00000208167.2 Gm39079 ENSMUST00000208167.2 predicted gene, 39079, transcript variant 1 (from RefSeq NR_188160.1) ENSMUST00000208167.1 NR_188160 uc291uxr.1 uc291uxr.2 uc291uxr.1 uc291uxr.2 
ENSMUST00000208175.2 Or4k50-ps1 ENSMUST00000208175.2 Or4k50-ps1 (from geneSymbol) ENSMUST00000208175.1 NR_190789 uc008lnx.1 uc008lnx.2 uc008lnx.3 uc008lnx.4 uc008lnx.5 uc008lnx.6 uc008lnx.1 uc008lnx.2 uc008lnx.3 uc008lnx.4 uc008lnx.5 uc008lnx.6 
ENSMUST00000208176.3 Or4k37 ENSMUST00000208176.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQY6) ENSMUST00000208176.1 ENSMUST00000208176.2 Olfr1281 Or4k37 Q7TQY6 Q7TQY6_MOUSE uc289zep.1 uc289zep.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zep.1 uc289zep.2 
ENSMUST00000208183.3 Map3k19 ENSMUST00000208183.3 mitogen-activated protein kinase kinase kinase 19 (from RefSeq NM_011737.2) A0A140LHL6 A0A140LHL6_MOUSE ENSMUST00000208183.1 ENSMUST00000208183.2 Map3k19 NM_011737 uc287ljy.1 uc287ljy.2 uc287ljy.3 protein kinase activity ATP binding protein phosphorylation uc287ljy.1 uc287ljy.2 uc287ljy.3 
ENSMUST00000208188.2 Gm44675 ENSMUST00000208188.2 Gm44675 (from geneSymbol) ENSMUST00000208188.1 uc291sqd.1 uc291sqd.2 uc291sqd.1 uc291sqd.2 
ENSMUST00000208189.3 4933402C05Rik ENSMUST00000208189.3 4933402C05Rik (from geneSymbol) AK016609 ENSMUST00000208189.1 ENSMUST00000208189.2 uc291kzz.1 uc291kzz.2 uc291kzz.3 uc291kzz.1 uc291kzz.2 uc291kzz.3 
ENSMUST00000208190.2 Nap1l4 ENSMUST00000208190.2 nucleosome assembly protein 1-like 4, transcript variant 1 (from RefSeq NM_001285489.1) B7ZNL2 B7ZNL2_MOUSE ENSMUST00000208190.1 NM_001285489 Nap1l4 uc009kpm.1 uc009kpm.2 uc009kpm.3 uc009kpm.4 Belongs to the nucleosome assembly protein (NAP) family. nucleus cytoplasm nucleosome assembly nucleosome binding uc009kpm.1 uc009kpm.2 uc009kpm.3 uc009kpm.4 
ENSMUST00000208199.2 Samd4b ENSMUST00000208199.2 sterile alpha motif domain containing 4B (from RefSeq NM_175021.3) ENSMUST00000208199.1 G5E8A7 G5E8A7_MOUSE NM_175021 Samd4b uc009fyw.1 uc009fyw.2 uc009fyw.3 Cytoplasm Belongs to the SMAUG family. RNA binding cytosol negative regulation of translation translation repressor activity regulation of mRNA stability uc009fyw.1 uc009fyw.2 uc009fyw.3 
ENSMUST00000208201.2 Gm45867 ENSMUST00000208201.2 Gm45867 (from geneSymbol) ENSMUST00000208201.1 LF222189 uc291sau.1 uc291sau.2 uc291sau.1 uc291sau.2 
ENSMUST00000208216.2 Dcst2 ENSMUST00000208216.2 DC-STAMP domain containing 2 (from RefSeq NM_001370853.1) A0A140LIJ0 DCST2_MOUSE Dcst2 ENSMUST00000208216.1 NM_001370853 uc290gwo.1 uc290gwo.2 Essential sperm cell-surface protein required for sperm-egg fusion and fertilization. Interacts with DCST1. Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Multi-pass membrane protein Note=Localizes in the anterior acrosome before the acrosome reaction and then translocates to the equatorial segment in acrosome-reacted sperm. Expressed in testis. In testis, not detected before 3 weeks after birth. Knockout males are completely sterile despite normal mating behavior with ejaculation and vaginal plug formation (PubMed:33871360, PubMed:35393517). DCST1 and DCST2 double knockout males, but not females, are completely infertile. Mutants have no disturbances in sperm migration into the oviduct, acrosome reaction and zona penetration. Mutant spermatozoa are capable of binding to the plasma membranes of oocytes but fail to proceed to membrane fusion with oocytes (PubMed:33871360, PubMed:35393517). molecular_function cellular_component biological_process membrane integral component of membrane uc290gwo.1 uc290gwo.2 
ENSMUST00000208217.2 Cyb5r2 ENSMUST00000208217.2 cytochrome b5 reductase 2, transcript variant 2 (from RefSeq NM_177216.4) ENSMUST00000208217.1 NB5R2_MOUSE NM_177216 Q3KNK3 Q3UGG1 Q8BUG7 uc009jbi.1 uc009jbi.2 uc009jbi.3 uc009jbi.4 NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4- disulfophenyl]-2H tetrazolium monosodium salt (WST-1) (By similarity). Reaction=2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+); Xref=Rhea:RHEA:46680, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.2.2; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3KNK3-1; Sequence=Displayed; Name=2; IsoId=Q3KNK3-2; Sequence=VSP_025560; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. cytochrome-b5 reductase activity, acting on NAD(P)H mitochondrion lipid metabolic process steroid biosynthetic process steroid metabolic process membrane sterol biosynthetic process oxidoreductase activity oxidation-reduction process FAD binding uc009jbi.1 uc009jbi.2 uc009jbi.3 uc009jbi.4 
ENSMUST00000208218.3 Gm38944 ENSMUST00000208218.3 Gm38944 (from geneSymbol) ENSMUST00000208218.1 ENSMUST00000208218.2 uc291lbj.1 uc291lbj.2 uc291lbj.3 uc291lbj.1 uc291lbj.2 uc291lbj.3 
ENSMUST00000208222.2 Sesn3 ENSMUST00000208222.2 sestrin 3 (from RefSeq NM_030261.4) ENSMUST00000208222.1 NM_030261 Q3U2A0 Q9CYP7 SESN3_MOUSE Sesn3 uc009oej.1 uc009oej.2 uc009oej.3 May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25259925). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (PubMed:25377878). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N- terminal domain of the protein (By similarity). Reaction=a hydroperoxide + L-cysteinyl-[protein] = an alcohol + S- hydroxy-L-cysteinyl-[protein]; Xref=Rhea:RHEA:67124, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:17193, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:61973; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67125; Evidence=; Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is not regulated by leucine (By similarity). Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them (PubMed:25259925). Interacts with the TORC2 complex; through RICTOR (PubMed:25377878). Cytoplasm Detected in liver and skeletal muscles. The N-terminal domain may have an alkylhydroperoxide reductase activity. The C-terminal domain mediates interaction with GATOR2 through which it regulates TORC1 signaling. Liver-specific Sesn3 knockout mice display insulin resistance and glucose intolerance (PubMed:25377878). Sesn2 and Sesn3 double knockout mice display insulin resistance and glucose intolerance (PubMed:22958918). Triple knockout mice lacking Sesn1, Sesn2 and Sesn3 do not display an embryonic lethal phenotype since they are born at an expected Mendelian ratio. Moreover, they are not distinguishable from their wild-type littermate. However, their survival at 10 days is dramatically affected. This is associated with a constitutive activation of TORC1 signaling in the liver, heart and skeletal muscle during postnatal fasting, that occurs between birth and suckling (PubMed:25259925). Belongs to the sestrin family. protein binding nucleus cytoplasm positive regulation of macroautophagy oxidoreductase activity oxidoreductase activity, acting on peroxide as acceptor response to insulin cellular response to amino acid starvation TORC2 signaling cellular response to glucose starvation glucose homeostasis regulation of insulin receptor signaling pathway regulation of protein kinase B signaling oxidation-reduction process GATOR2 complex leucine binding cellular response to amino acid stimulus cellular response to leucine regulation of response to reactive oxygen species negative regulation of TORC1 signaling cellular response to leucine starvation TORC2 complex uc009oej.1 uc009oej.2 uc009oej.3 
ENSMUST00000208228.2 Gm44700 ENSMUST00000208228.2 Gm44700 (from geneSymbol) ENSMUST00000208228.1 uc291nnb.1 uc291nnb.2 uc291nnb.1 uc291nnb.2 
ENSMUST00000208229.2 Gm44699 ENSMUST00000208229.2 Gm44699 (from geneSymbol) ENSMUST00000208229.1 uc291nno.1 uc291nno.2 uc291nno.1 uc291nno.2 
ENSMUST00000208235.2 Nbdy ENSMUST00000208235.2 negative regulator of P-body association (from RefSeq NM_027327.1) 2210013O21Rik A0A140LJI0 A0A140LJI0_MOUSE ENSMUST00000208235.1 NM_027327 Nbdy uc292rid.1 uc292rid.2 The protein encoded by this gene is a 43 aa peptide produced by early activated CD4+ T cells. The encoded protein helps regulate the differentiation of these cells into T helper 2 (Th2) cells. The solution structure of this protein is similar to that of vasoactive intestinal peptide, which plays a role in the differentiation of Th2 cells and Treg cells. [provided by RefSeq, Jun 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BI109108.1, AK008724.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## uc292rid.1 uc292rid.2 
ENSMUST00000208237.2 Gm39128 ENSMUST00000208237.2 Gm39128 (from geneSymbol) ENSMUST00000208237.1 uc291yba.1 uc291yba.2 uc291yba.1 uc291yba.2 
ENSMUST00000208244.3 Or5ac16 ENSMUST00000208244.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TS40) A0A140LIG6 ENSMUST00000208244.1 ENSMUST00000208244.2 Olfr198 Or5ac16 Q7TS40 Q7TS40_MOUSE uc007zow.1 uc007zow.2 uc007zow.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007zow.1 uc007zow.2 uc007zow.3 
ENSMUST00000208247.3 Adam9 ENSMUST00000208247.3 ADAM metallopeptidase domain 9, transcript variant 2 (from RefSeq NM_007404.2) A0A140LHU0 A0A140LHU0_MOUSE Adam9 ENSMUST00000208247.1 ENSMUST00000208247.2 NM_007404 uc009lfl.1 uc009lfl.2 uc009lfl.3 uc009lfl.4 Membrane ; Single- pass type I membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. activation of MAPKK activity metalloendopeptidase activity integrin binding collagen binding proteolysis membrane protein ectodomain proteolysis cell adhesion cell-matrix adhesion transforming growth factor beta receptor signaling pathway metallopeptidase activity cell surface response to manganese ion membrane integral component of membrane basolateral plasma membrane SH3 domain binding keratinocyte differentiation cell adhesion mediated by integrin positive regulation of cell adhesion mediated by integrin cell-cell adhesion mediated by integrin positive regulation of macrophage fusion response to tumor necrosis factor response to laminar fluid shear stress monocyte activation response to hydrogen peroxide laminin binding positive regulation of protein secretion positive regulation of keratinocyte migration response to calcium ion cellular response to lipopolysaccharide response to antineoplastic agent uc009lfl.1 uc009lfl.2 uc009lfl.3 uc009lfl.4 
ENSMUST00000208250.2 Gm34280 ENSMUST00000208250.2 Gm34280 (from geneSymbol) ENSMUST00000208250.1 uc291tag.1 uc291tag.2 uc291tag.1 uc291tag.2 
ENSMUST00000208253.2 Med25 ENSMUST00000208253.2 mediator complex subunit 25, transcript variant 3 (from RefSeq NM_001331207.2) A0A140LHG7 A0A140LHG7_MOUSE ENSMUST00000208253.1 Med25 NM_001331207 uc009grn.1 uc009grn.2 uc009grn.3 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Component of the Mediator complex. Nucleus Belongs to the Mediator complex subunit 25 family. uc009grn.1 uc009grn.2 uc009grn.3 
ENSMUST00000208257.3 4833412C05Rik ENSMUST00000208257.3 4833412C05Rik (from geneSymbol) AK014683 ENSMUST00000208257.1 ENSMUST00000208257.2 uc291rez.1 uc291rez.2 uc291rez.3 uc291rez.1 uc291rez.2 uc291rez.3 
ENSMUST00000208262.2 Gm44545 ENSMUST00000208262.2 Gm44545 (from geneSymbol) AK033028 ENSMUST00000208262.1 uc291tfa.1 uc291tfa.2 uc291tfa.1 uc291tfa.2 
ENSMUST00000208277.2 Gm44956 ENSMUST00000208277.2 Gm44956 (from geneSymbol) ENSMUST00000208277.1 uc291ycp.1 uc291ycp.2 uc291ycp.1 uc291ycp.2 
ENSMUST00000208279.2 Gm45001 ENSMUST00000208279.2 Gm45001 (from geneSymbol) ENSMUST00000208279.1 uc291qhz.1 uc291qhz.2 uc291qhz.1 uc291qhz.2 
ENSMUST00000208280.2 Gm45114 ENSMUST00000208280.2 Gm45114 (from geneSymbol) ENSMUST00000208280.1 uc291mmn.1 uc291mmn.2 uc291mmn.1 uc291mmn.2 
ENSMUST00000208284.3 Or4k48 ENSMUST00000208284.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGE6) ENSMUST00000208284.1 ENSMUST00000208284.2 Olfr1298 Olfr1302 Or4k48 Q8VGE6 Q8VGE6_MOUSE uc289zfo.1 uc289zfo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zfo.1 uc289zfo.2 
ENSMUST00000208287.2 Gm44763 ENSMUST00000208287.2 Gm44763 (from geneSymbol) ENSMUST00000208287.1 LF196559 uc291uwq.1 uc291uwq.2 uc291uwq.1 uc291uwq.2 
ENSMUST00000208290.2 Ryr3 ENSMUST00000208290.2 ryanodine receptor 3 (from RefSeq NM_001319156.1) A0A140LJK7 A0A140LJK7_MOUSE ENSMUST00000208290.1 NM_001319156 Ryr3 uc057boa.1 uc057boa.2 uc057boa.3 uc057boa.4 Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671, ChEBI:CHEBI:29108; Evidence=; Membrane ; Multi- pass membrane protein Sarcoplasmic reticulum membrane ; Multi-pass membrane protein ion channel activity ryanodine-sensitive calcium-release channel activity calcium channel activity calcium ion binding endoplasmic reticulum ion transport calcium ion transport cellular calcium ion homeostasis calcium-release channel activity membrane integral component of membrane perinuclear region of cytoplasm calcium-induced calcium release activity release of sequestered calcium ion into cytosol negative regulation of cytosolic calcium ion concentration transmembrane transport calcium ion transmembrane transport uc057boa.1 uc057boa.2 uc057boa.3 uc057boa.4 
ENSMUST00000208295.3 Gm45175 ENSMUST00000208295.3 Gm45175 (from geneSymbol) ENSMUST00000208295.1 ENSMUST00000208295.2 uc291sew.1 uc291sew.2 uc291sew.3 uc291sew.1 uc291sew.2 uc291sew.3 
ENSMUST00000208296.2 Or5p61 ENSMUST00000208296.2 olfactory receptor family 5 subfamily P member 61 (from RefSeq NM_001011810.2) A0A140LJF5 A0A140LJF5_MOUSE ENSMUST00000208296.1 NM_001011810 Olfr485 Or5p61 uc009jca.1 uc009jca.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jca.1 uc009jca.2 
ENSMUST00000208300.2 Gm34549 ENSMUST00000208300.2 Gm34549 (from geneSymbol) ENSMUST00000208300.1 uc291rfy.1 uc291rfy.2 uc291rfy.1 uc291rfy.2 
ENSMUST00000208302.2 Gm44751 ENSMUST00000208302.2 Gm44751 (from geneSymbol) AK142945 ENSMUST00000208302.1 uc291sla.1 uc291sla.2 uc291sla.1 uc291sla.2 
ENSMUST00000208305.2 Gm44809 ENSMUST00000208305.2 Gm44809 (from geneSymbol) ENSMUST00000208305.1 uc291rhv.1 uc291rhv.2 uc291rhv.1 uc291rhv.2 
ENSMUST00000208311.4 Dmbt1 ENSMUST00000208311.4 deleted in malignant brain tumors 1, transcript variant 1 (from RefSeq NM_001347632.2) A0A140LI59 A0A140LI59_MOUSE Dmbt1 ENSMUST00000208311.1 ENSMUST00000208311.2 ENSMUST00000208311.3 NM_001347632 mCG_1606 uc009kax.1 uc009kax.2 uc009kax.3 uc009kax.4 Belongs to the DMBT1 family. Lacks conserved residue(s) required for the propagation of feature annotation. scavenger receptor activity extracellular region endocytosis membrane integral component of membrane uc009kax.1 uc009kax.2 uc009kax.3 uc009kax.4 
ENSMUST00000208320.2 Gm44843 ENSMUST00000208320.2 Gm44843 (from geneSymbol) AK157505 ENSMUST00000208320.1 uc291xzk.1 uc291xzk.2 uc291xzk.1 uc291xzk.2 
ENSMUST00000208325.2 Gm44861 ENSMUST00000208325.2 Gm44861 (from geneSymbol) AK138951 ENSMUST00000208325.1 uc291snl.1 uc291snl.2 uc291snl.1 uc291snl.2 
ENSMUST00000208329.2 Gm38451 ENSMUST00000208329.2 Gm38451 (from geneSymbol) AK034336 ENSMUST00000208329.1 uc291qwi.1 uc291qwi.2 uc291qwi.1 uc291qwi.2 
ENSMUST00000208332.3 Gm45022 ENSMUST00000208332.3 Gm45022 (from geneSymbol) ENSMUST00000208332.1 ENSMUST00000208332.2 uc292rhx.1 uc292rhx.2 uc292rhx.3 uc292rhx.1 uc292rhx.2 uc292rhx.3 
ENSMUST00000208333.2 B830042I05Rik ENSMUST00000208333.2 B830042I05Rik (from geneSymbol) ENSMUST00000208333.1 uc291ycr.1 uc291ycr.2 uc291ycr.1 uc291ycr.2 
ENSMUST00000208339.3 Gm44787 ENSMUST00000208339.3 Gm44787 (from geneSymbol) ENSMUST00000208339.1 ENSMUST00000208339.2 uc288aqj.1 uc288aqj.2 uc288aqj.3 uc288aqj.1 uc288aqj.2 uc288aqj.3 
ENSMUST00000208344.2 Gm45737 ENSMUST00000208344.2 Gm45737 (from geneSymbol) ENSMUST00000208344.1 LF196321 uc291qcv.1 uc291qcv.2 uc291qcv.1 uc291qcv.2 
ENSMUST00000208351.2 Gm44549 ENSMUST00000208351.2 Gm44549 (from geneSymbol) AK042894 ENSMUST00000208351.1 uc291uwd.1 uc291uwd.2 uc291uwd.1 uc291uwd.2 
ENSMUST00000208353.2 Gm44546 ENSMUST00000208353.2 Gm44546 (from geneSymbol) ENSMUST00000208353.1 uc291wja.1 uc291wja.2 uc291wja.1 uc291wja.2 
ENSMUST00000208364.2 Gm44531 ENSMUST00000208364.2 Gm44531 (from geneSymbol) ENSMUST00000208364.1 uc291sdr.1 uc291sdr.2 uc291sdr.1 uc291sdr.2 
ENSMUST00000208376.2 Gm10067 ENSMUST00000208376.2 Gm10067 (from geneSymbol) AK147851 ENSMUST00000208376.1 uc291ybs.1 uc291ybs.2 uc291ybs.1 uc291ybs.2 
ENSMUST00000208383.2 Gm35147 ENSMUST00000208383.2 Gm35147 (from geneSymbol) AK035726 ENSMUST00000208383.1 uc057lvm.1 uc057lvm.2 uc057lvm.1 uc057lvm.2 
ENSMUST00000208395.2 Gm44584 ENSMUST00000208395.2 Gm44584 (from geneSymbol) ENSMUST00000208395.1 uc291ldp.1 uc291ldp.2 uc291ldp.1 uc291ldp.2 
ENSMUST00000208396.2 Or5b100-ps1 ENSMUST00000208396.2 Or5b100-ps1 (from geneSymbol) ENSMUST00000208396.1 uc289rdx.1 uc289rdx.2 uc289rdx.1 uc289rdx.2 
ENSMUST00000208398.3 Or5a21 ENSMUST00000208398.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A140LHS9) A0A140LHS9 A0A140LHS9_MOUSE ENSMUST00000208398.1 ENSMUST00000208398.2 Olfr1438 Or5a21 uc289rbt.1 uc289rbt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rbt.1 uc289rbt.2 
ENSMUST00000208401.2 Gm44588 ENSMUST00000208401.2 Gm44588 (from geneSymbol) ENSMUST00000208401.1 uc291uww.1 uc291uww.2 uc291uww.1 uc291uww.2 
ENSMUST00000208403.2 Gm49493 ENSMUST00000208403.2 Gm49493 (from geneSymbol) DQ726868 ENSMUST00000208403.1 uc291sdv.1 uc291sdv.2 uc291sdv.1 uc291sdv.2 
ENSMUST00000208414.2 Gm44680 ENSMUST00000208414.2 Gm44680 (from geneSymbol) ENSMUST00000208414.1 uc291sqg.1 uc291sqg.2 uc291sqg.1 uc291sqg.2 
ENSMUST00000208416.2 D530014G21Rik ENSMUST00000208416.2 D530014G21Rik (from geneSymbol) AK021287 ENSMUST00000208416.1 uc291yah.1 uc291yah.2 uc291yah.1 uc291yah.2 
ENSMUST00000208417.3 Gvin-ps7 ENSMUST00000208417.3 Gvin-ps7 (from geneSymbol) AK134184 ENSMUST00000208417.1 ENSMUST00000208417.2 uc291uce.1 uc291uce.2 uc291uce.3 uc291uce.1 uc291uce.2 uc291uce.3 
ENSMUST00000208418.2 Fam81b ENSMUST00000208418.2 family with sequence similarity 81, member B (from RefSeq NM_001370926.1) A0A140LI28 A0A140LI28_MOUSE ENSMUST00000208418.1 Fam81b NM_001370926 uc288orv.1 uc288orv.2 molecular_function biological_process uc288orv.1 uc288orv.2 
ENSMUST00000208431.2 Gm44618 ENSMUST00000208431.2 Gm44618 (from geneSymbol) ENSMUST00000208431.1 uc291nkx.1 uc291nkx.2 uc291nkx.1 uc291nkx.2 
ENSMUST00000208432.2 4933423L19Rik ENSMUST00000208432.2 4933423L19Rik (from geneSymbol) DQ710922 ENSMUST00000208432.1 uc291rgx.1 uc291rgx.2 uc291rgx.1 uc291rgx.2 
ENSMUST00000208435.2 Gm44993 ENSMUST00000208435.2 Gm44993 (from geneSymbol) ENSMUST00000208435.1 uc291sdo.1 uc291sdo.2 uc291sdo.1 uc291sdo.2 
ENSMUST00000208444.2 Gm45129 ENSMUST00000208444.2 Gm45129 (from geneSymbol) ENSMUST00000208444.1 uc291sqn.1 uc291sqn.2 uc291sqn.1 uc291sqn.2 
ENSMUST00000208447.2 Gm44681 ENSMUST00000208447.2 Gm44681 (from geneSymbol) AK080439 ENSMUST00000208447.1 uc291sqh.1 uc291sqh.2 uc291sqh.1 uc291sqh.2 
ENSMUST00000208452.2 Gm45179 ENSMUST00000208452.2 Gm45179 (from geneSymbol) AK139352 ENSMUST00000208452.1 uc291spq.1 uc291spq.2 uc291spq.1 uc291spq.2 
ENSMUST00000208455.3 Or5h25 ENSMUST00000208455.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TS43) A0A140LHF5 ENSMUST00000208455.1 ENSMUST00000208455.2 Olfr193 Or5h25 Q7TS43 Q7TS43_MOUSE uc007zor.1 uc007zor.2 uc007zor.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007zor.1 uc007zor.2 uc007zor.3 
ENSMUST00000208462.2 Gm44947 ENSMUST00000208462.2 Gm44947 (from geneSymbol) ENSMUST00000208462.1 uc291ssk.1 uc291ssk.2 uc291ssk.1 uc291ssk.2 
ENSMUST00000208466.3 Gm39119 ENSMUST00000208466.3 Gm39119 (from geneSymbol) ENSMUST00000208466.1 ENSMUST00000208466.2 uc291xqz.1 uc291xqz.2 uc291xqz.3 uc291xqz.1 uc291xqz.2 uc291xqz.3 
ENSMUST00000208469.2 Gm44831 ENSMUST00000208469.2 Gm44831 (from geneSymbol) AK045462 ENSMUST00000208469.1 uc291qss.1 uc291qss.2 uc291qss.1 uc291qss.2 
ENSMUST00000208471.3 Bc1-ps1 ENSMUST00000208471.3 Bc1-ps1 (from geneSymbol) ENSMUST00000208471.1 ENSMUST00000208471.2 uc291ssp.1 uc291ssp.2 uc291ssp.1 uc291ssp.2 
ENSMUST00000208473.2 Gm44860 ENSMUST00000208473.2 Gm44860 (from geneSymbol) ENSMUST00000208473.1 uc291snk.1 uc291snk.2 uc291snk.1 uc291snk.2 
ENSMUST00000208484.2 D7Bwg0826e ENSMUST00000208484.2 D7Bwg0826e (from geneSymbol) ENSMUST00000208484.1 LF300218 uc291pks.1 uc291pks.2 uc291pks.1 uc291pks.2 
ENSMUST00000208490.2 Gm44873 ENSMUST00000208490.2 Gm44873 (from geneSymbol) AK146676 ENSMUST00000208490.1 uc291nsc.1 uc291nsc.2 uc291nsc.1 uc291nsc.2 
ENSMUST00000208493.3 Or9i2 ENSMUST00000208493.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFQ3) ENSMUST00000208493.1 ENSMUST00000208493.2 Olfr1501 Or9i2 Q8VFQ3 Q8VFQ3_MOUSE uc289rhi.1 uc289rhi.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rhi.1 uc289rhi.2 
ENSMUST00000208494.3 Or5b94 ENSMUST00000208494.3 Membrane ; Multi- pass membrane protein (from UniProt Q0VEV7) A0A140LI29 A0A140LJ26 ENSMUST00000208494.1 ENSMUST00000208494.2 Olfr1442 Or5b94 Q0VEV7 Q0VEV7_MOUSE uc289rcr.1 uc289rcr.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rcr.1 uc289rcr.2 
ENSMUST00000208498.2 9330162G02Rik ENSMUST00000208498.2 9330162G02Rik (from geneSymbol) ENSMUST00000208498.1 LF192513 uc009hek.1 uc009hek.2 uc009hek.3 uc009hek.1 uc009hek.2 uc009hek.3 
ENSMUST00000208501.2 Gm44682 ENSMUST00000208501.2 Gm44682 (from geneSymbol) ENSMUST00000208501.1 uc291qis.1 uc291qis.2 uc291qis.1 uc291qis.2 
ENSMUST00000208508.3 Gm16675 ENSMUST00000208508.3 Gm16675 (from geneSymbol) AK144632 ENSMUST00000208508.1 ENSMUST00000208508.2 uc291zsy.1 uc291zsy.2 uc291zsy.1 uc291zsy.2 
ENSMUST00000208510.3 Ankrd40cl ENSMUST00000208510.3 ANKRD40 C-terminal like (from RefSeq NM_001378258.1) A0A286YDN8 A0A286YDN8_MOUSE Ankrd40cl ENSMUST00000208510.1 ENSMUST00000208510.2 Gm21885 NM_001378258 uc288bkw.1 uc288bkw.2 uc288bkw.1 uc288bkw.2 
ENSMUST00000208511.2 Gm29683 ENSMUST00000208511.2 predicted gene, 29683, transcript variant 2 (from RefSeq NR_131145.1) ENSMUST00000208511.1 NR_131145 uc057ahu.1 uc057ahu.2 uc057ahu.3 uc057ahu.1 uc057ahu.2 uc057ahu.3 
ENSMUST00000208520.2 Gm44676 ENSMUST00000208520.2 Gm44676 (from geneSymbol) AK047139 ENSMUST00000208520.1 uc291sqe.1 uc291sqe.2 uc291sqe.1 uc291sqe.2 
ENSMUST00000208521.2 Cers3 ENSMUST00000208521.2 Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22) (PubMed:16753040, PubMed:18541923, PubMed:22038835). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:16753040, PubMed:18541923, PubMed:22038835). It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:22038835). (from UniProt Q1A3B0) CERS3_MOUSE Cers3 DQ358087 E9PVY9 ENSMUST00000208521.1 Lass3 Q195J4 Q1A3B0 uc291rcu.1 uc291rcu.2 Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22) (PubMed:16753040, PubMed:18541923, PubMed:22038835). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:16753040, PubMed:18541923, PubMed:22038835). It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:22038835). Reaction=a sphingoid base + a very long-chain fatty acyl-CoA = an N- (very-long-chain fatty acyl)-sphingoid base + CoA + H(+); Xref=Rhea:RHEA:61480, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:84410, ChEBI:CHEBI:138261, ChEBI:CHEBI:144712; EC=2.3.1.297; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61481; Evidence= Reaction=docosanoyl-CoA + sphinganine = CoA + H(+) + N- docosanoylsphinganine; Xref=Rhea:RHEA:36535, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:65059, ChEBI:CHEBI:67021; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36536; Evidence=; Reaction=sphinganine + tetracosanoyl-CoA = CoA + H(+) + N- tetracosanoylsphinganine; Xref=Rhea:RHEA:33591, ChEBI:CHEBI:15378, ChEBI:CHEBI:52961, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:65052; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33592; Evidence=; Reaction=hexacosanoyl-CoA + sphinganine = CoA + H(+) + N- hexacosanoylsphinganine; Xref=Rhea:RHEA:33351, ChEBI:CHEBI:15378, ChEBI:CHEBI:52962, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:64868; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33352; Evidence=; Reaction=2-hydroxydocosanoyl-CoA + sphinganine = CoA + H(+) + N-(2- hydroxydocosanoyl)-sphinganine; Xref=Rhea:RHEA:36619, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:67023, ChEBI:CHEBI:74117; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36620; Evidence=; Reaction=2-hydroxytetracosanoyl-CoA + sphinganine = CoA + H(+) + N-(2- hydroxytetracosanoyl)-sphinganine; Xref=Rhea:RHEA:36627, ChEBI:CHEBI:15378, ChEBI:CHEBI:52371, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:74118; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36628; Evidence=; Reaction=a sphingoid base + an ultra-long-chain fatty acyl-CoA = an N- (ultra-long-chain-acyl)-sphingoid base + CoA + H(+); Xref=Rhea:RHEA:61492, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:84410, ChEBI:CHEBI:143018, ChEBI:CHEBI:144713; EC=2.3.1.298; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61493; Evidence=; Reaction=octacosanoyl-CoA + sphinganine = CoA + H(+) + N- (octacosanoyl)-sphinganine; Xref=Rhea:RHEA:36675, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:72019, ChEBI:CHEBI:74141; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36676; Evidence=; Reaction=a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+); Xref=Rhea:RHEA:23768, ChEBI:CHEBI:15378, ChEBI:CHEBI:52639, ChEBI:CHEBI:57287, ChEBI:CHEBI:57756, ChEBI:CHEBI:77636; EC=2.3.1.24; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23769; Evidence=; Reaction=octadecanoyl-CoA + sphinganine = CoA + H(+) + N- (octadecanoyl)-sphinganine; Xref=Rhea:RHEA:36547, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57817, ChEBI:CHEBI:67033; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36548; Evidence=; Reaction=2-hydroxyoctadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2- hydroxyoctadecanoyl)-sphinganine; Xref=Rhea:RHEA:36615, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:67034, ChEBI:CHEBI:74116; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36616; Evidence=; Lipid metabolism; sphingolipid metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative promoter usage; Named isoforms=2; Name=1; IsoId=Q1A3B0-1; Sequence=Displayed; Name=2; Synonyms=LASS3-long ; IsoId=Q1A3B0-2; Sequence=VSP_047870; Predominantly expressed in testis (PubMed:16753040). In skin, present in the upper stratum spinosum and stratum granulosum (at protein level) (PubMed:22038835). Newborn mice die shortly after birth from transepidermal water loss (PubMed:22038835). Defects are due to a complete loss of ultra long chain (more than C26:0) ceramides (PubMed:22038835). Newborn skin appears unwrinkled, erythematous and sticky (PubMed:22038835). Skin is also prone to C.albicans infection (PubMed:22038835). Contains a predicted homeobox domain which is degenerated, lacking residues important for DNA-binding. Moreover, the protein localizes in the endoplasmic reticulum and not in the nucleus, which also argues against homeobox function (PubMed:22038835). DNA binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process sphingolipid metabolic process epidermis development membrane integral component of membrane transferase activity sphingolipid biosynthetic process keratinocyte differentiation ceramide biosynthetic process sphingosine N-acyltransferase activity cornification uc291rcu.1 uc291rcu.2 
ENSMUST00000208530.2 Clhc1 ENSMUST00000208530.2 clathrin heavy chain linker domain containing 1, transcript variant 2 (from RefSeq NM_001163521.1) 1700034F02Rik B7ZMV8 B7ZMV8_MOUSE Clhc1 ENSMUST00000208530.1 NM_001163521 uc011xsr.1 uc011xsr.2 uc011xsr.3 uc011xsr.1 uc011xsr.2 uc011xsr.3 
ENSMUST00000208533.3 Or5b108 ENSMUST00000208533.3 Membrane ; Multi- pass membrane protein (from UniProt Q8VFW3) ENSMUST00000208533.1 ENSMUST00000208533.2 Olfr1462 Or5b108 Q8VFW3 Q8VFW3_MOUSE uc289ren.1 uc289ren.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ren.1 uc289ren.2 
ENSMUST00000208537.2 Gm45698 ENSMUST00000208537.2 Gm45698 (from geneSymbol) AK080200 ENSMUST00000208537.1 uc291rzt.1 uc291rzt.2 uc291rzt.1 uc291rzt.2 
ENSMUST00000208538.2 Arhgap33 ENSMUST00000208538.2 Rho GTPase activating protein 33, transcript variant 2 (from RefSeq NM_001289682.1) ENSMUST00000208538.1 NM_001289682 Q6P7W6 Q80YF9 RHG33_MOUSE Snx26 Tcgap uc009ger.1 uc009ger.2 uc009ger.3 uc009ger.4 May be involved in several stages of intracellular trafficking (By similarity). Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport. Specifically interacts with CDC42 and RHOQ/TC10 through its Rho-GAP domain. Interacts with NEK6 (By similarity). Cell membrane Note=Translocates to the plasma membrane in response to insulin in adipocytes. Highly expressed in brain and testis. Also expressed in white adipose tissue (WAT) and muscle at a low level. Dramatically induced during adipocyte differentiation. The N-terminal PX domain interacts specifically with phosphatidylinositol 4,5-bisphosphate. Belongs to the PX domain-containing GAP family. Sequence=AAH61471.1; Type=Erroneous initiation; Evidence=; GTPase activator activity protein binding cytoplasm plasma membrane signal transduction small GTPase mediated signal transduction response to toxic substance protein transport membrane protein kinase binding macromolecular complex phosphatidylinositol binding dendritic spine positive regulation of GTPase activity regulation of dendritic spine morphogenesis uc009ger.1 uc009ger.2 uc009ger.3 uc009ger.4 
ENSMUST00000208539.3 Or2n1d ENSMUST00000208539.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG72) A0A140LJD0 ENSMUST00000208539.1 ENSMUST00000208539.2 Olfr136 Olfr138 Or2n1d Q8VG72 Q8VG72_MOUSE uc289lcb.1 uc289lcb.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lcb.1 uc289lcb.2 
ENSMUST00000208543.2 Gm19656 ENSMUST00000208543.2 Gm19656 (from geneSymbol) AK155017 ENSMUST00000208543.1 uc009iku.1 uc009iku.2 uc009iku.3 uc009iku.1 uc009iku.2 uc009iku.3 
ENSMUST00000208559.2 Gm44822 ENSMUST00000208559.2 Gm44822 (from geneSymbol) ENSMUST00000208559.1 uc057ahl.1 uc057ahl.2 uc057ahl.3 uc057ahl.1 uc057ahl.2 uc057ahl.3 
ENSMUST00000208576.2 Gm45112 ENSMUST00000208576.2 Gm45112 (from geneSymbol) ENSMUST00000208576.1 uc291vag.1 uc291vag.2 uc291vag.1 uc291vag.2 
ENSMUST00000208577.2 Frmpd2 ENSMUST00000208577.2 Frmpd2 (from geneSymbol) A0A140LI67 A0A140LI67_MOUSE AK136780 ENSMUST00000208577.1 Frmpd2 Gm626 uc288sig.1 uc288sig.2 1-phosphatidylinositol binding cytoskeleton bicellular tight junction basolateral plasma membrane bicellular tight junction assembly uc288sig.1 uc288sig.2 
ENSMUST00000208578.2 Gm45148 ENSMUST00000208578.2 Gm45148 (from geneSymbol) ENSMUST00000208578.1 uc291lat.1 uc291lat.2 uc291lat.1 uc291lat.2 
ENSMUST00000208587.2 Gm44919 ENSMUST00000208587.2 Gm44919 (from geneSymbol) ENSMUST00000208587.1 uc291sbp.1 uc291sbp.2 uc291sbp.1 uc291sbp.2 
ENSMUST00000208593.2 Btbd16 ENSMUST00000208593.2 BTB domain containing 16, transcript variant 2 (from RefSeq NM_001374628.1) A0A140LIJ9 A0A140LIJ9_MOUSE Btbd16 ENSMUST00000208593.1 NM_001374628 uc291wgs.1 uc291wgs.2 uc291wgs.1 uc291wgs.2 
ENSMUST00000208595.2 Gm44892 ENSMUST00000208595.2 Gm44892 (from geneSymbol) ENSMUST00000208595.1 uc291wjk.1 uc291wjk.2 uc291wjk.1 uc291wjk.2 
ENSMUST00000208604.3 Gm45069 ENSMUST00000208604.3 Gm45069 (from geneSymbol) ENSMUST00000208604.1 ENSMUST00000208604.2 uc291lbb.1 uc291lbb.2 uc291lbb.3 uc291lbb.1 uc291lbb.2 uc291lbb.3 
ENSMUST00000208621.2 9130015G15Rik ENSMUST00000208621.2 RIKEN cDNA 9130015G15 gene (from RefSeq NR_154465.1) ENSMUST00000208621.1 NR_154465 uc009hbf.1 uc009hbf.2 uc009hbf.1 uc009hbf.2 
ENSMUST00000208629.2 Gm45231 ENSMUST00000208629.2 Gm45231 (from geneSymbol) AK029472 ENSMUST00000208629.1 uc291xux.1 uc291xux.2 uc291xux.1 uc291xux.2 
ENSMUST00000208630.2 Gm45159 ENSMUST00000208630.2 Gm45159 (from geneSymbol) ENSMUST00000208630.1 uc291spo.1 uc291spo.2 uc291spo.1 uc291spo.2 
ENSMUST00000208632.2 Gm45236 ENSMUST00000208632.2 Gm45236 (from geneSymbol) AK205233 ENSMUST00000208632.1 uc291uvm.1 uc291uvm.2 uc291uvm.1 uc291uvm.2 
ENSMUST00000208637.2 Gm44933 ENSMUST00000208637.2 Gm44933 (from geneSymbol) ENSMUST00000208637.1 uc291sev.1 uc291sev.2 uc291sev.1 uc291sev.2 
ENSMUST00000208648.2 Gm44652 ENSMUST00000208648.2 Gm44652 (from geneSymbol) ENSMUST00000208648.1 uc291uvc.1 uc291uvc.2 uc291uvc.1 uc291uvc.2 
ENSMUST00000208652.2 Gm45137 ENSMUST00000208652.2 Gm45137 (from geneSymbol) ENSMUST00000208652.1 uc291vbx.1 uc291vbx.2 uc291vbx.1 uc291vbx.2 
ENSMUST00000208660.2 Rp1 ENSMUST00000208660.2 retinitis pigmentosa 1 (human), transcript variant 3 (from RefSeq NM_001370921.1) A0A140LHJ6 A0A140LHJ6_MOUSE ENSMUST00000208660.1 NM_001370921 Rp1 uc287gdr.1 uc287gdr.2 This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jun 2019]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were inferred and based on orthologous transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## Lacks conserved residue(s) required for the propagation of feature annotation. catalase activity heme binding intracellular signal transduction oxidation-reduction process cellular oxidant detoxification uc287gdr.1 uc287gdr.2 
ENSMUST00000208663.2 Muc16 ENSMUST00000208663.2 Muc16 (from geneSymbol) A0A140LJ72 A0A140LJ72_MOUSE AK003577 ENSMUST00000208663.1 Muc16 uc292esq.1 uc292esq.2 molecular_function extracellular space external side of plasma membrane membrane integral component of membrane negative regulation of interleukin-6 biosynthetic process negative regulation of epithelial cell proliferation negative regulation of wound healing uc292esq.1 uc292esq.2 
ENSMUST00000208664.2 Gm44916 ENSMUST00000208664.2 Gm44916 (from geneSymbol) BC078450 ENSMUST00000208664.1 uc291sbz.1 uc291sbz.2 uc291sbz.1 uc291sbz.2 
ENSMUST00000208667.3 Or10w3 ENSMUST00000208667.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A140LHU2) A0A140LHU2 A0A140LHU2_MOUSE A0A140LHV4 ENSMUST00000208667.1 ENSMUST00000208667.2 Olfr1490 Olfr1493 Or10w3 uc289rgq.1 uc289rgq.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rgq.1 uc289rgq.2 
ENSMUST00000208668.2 Sdr42e2 ENSMUST00000208668.2 short chain dehydrogenase/reductase family 42E, member 2 (from RefSeq NM_001370881.1) A0A140LI11 A0A140LI11_MOUSE ENSMUST00000208668.1 Gm5737 NM_001370881 Sdr42e2 uc291vbd.1 uc291vbd.2 Belongs to the 3-beta-HSD family. 3-beta-hydroxy-delta5-steroid dehydrogenase activity steroid biosynthetic process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidation-reduction process uc291vbd.1 uc291vbd.2 
ENSMUST00000208669.2 Gm44991 ENSMUST00000208669.2 Gm44991 (from geneSymbol) ENSMUST00000208669.1 uc291sct.1 uc291sct.2 uc291sct.1 uc291sct.2 
ENSMUST00000208672.2 A930002H02Rik ENSMUST00000208672.2 A930002H02Rik (from geneSymbol) ENSMUST00000208672.1 uc291spm.1 uc291spm.2 uc291spm.1 uc291spm.2 
ENSMUST00000208673.2 Gm45072 ENSMUST00000208673.2 Gm45072 (from geneSymbol) ENSMUST00000208673.1 uc291qhw.1 uc291qhw.2 uc291qhw.1 uc291qhw.2 
ENSMUST00000208675.3 Or4k44 ENSMUST00000208675.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGE5) ENSMUST00000208675.1 ENSMUST00000208675.2 Olfr1294 Or4k44 Q8VGE5 Q8VGE5_MOUSE uc008lnr.1 uc008lnr.2 uc008lnr.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008lnr.1 uc008lnr.2 uc008lnr.3 
ENSMUST00000208677.2 Gm44542 ENSMUST00000208677.2 Gm44542 (from geneSymbol) AK033930 ENSMUST00000208677.1 uc057cbn.1 uc057cbn.2 uc057cbn.1 uc057cbn.2 
ENSMUST00000208688.2 Gm26810 ENSMUST00000208688.2 Gm26810 (from geneSymbol) AK043528 ENSMUST00000208688.1 uc291nto.1 uc291nto.2 uc291nto.1 uc291nto.2 
ENSMUST00000208694.2 Zfp317 ENSMUST00000208694.2 zinc finger protein 317, transcript variant 2 (from RefSeq NR_153375.1) ENSMUST00000208694.1 NR_153375 Q8C0Q5 Q8C0Q5_MOUSE Zfp317 Zfp75 uc009ohp.1 uc009ohp.2 uc009ohp.3 uc009ohp.4 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009ohp.1 uc009ohp.2 uc009ohp.3 uc009ohp.4 
ENSMUST00000208696.3 Gm32849 ENSMUST00000208696.3 Gm32849 (from geneSymbol) AK045483 ENSMUST00000208696.1 ENSMUST00000208696.2 uc009hbe.1 uc009hbe.2 uc009hbe.3 uc009hbe.4 uc009hbe.1 uc009hbe.2 uc009hbe.3 uc009hbe.4 
ENSMUST00000208699.2 A530021J07Rik ENSMUST00000208699.2 A530021J07Rik (from geneSymbol) AK040731 ENSMUST00000208699.1 uc291sci.1 uc291sci.2 uc291sci.1 uc291sci.2 
ENSMUST00000208700.2 Gm44624 ENSMUST00000208700.2 Gm44624 (from geneSymbol) ENSMUST00000208700.1 uc291wig.1 uc291wig.2 uc291wig.1 uc291wig.2 
ENSMUST00000208702.2 Gm45029 ENSMUST00000208702.2 Gm45029 (from geneSymbol) ENSMUST00000208702.1 uc289foc.1 uc289foc.2 uc289foc.1 uc289foc.2 
ENSMUST00000208709.2 Gm30692 ENSMUST00000208709.2 Gm30692 (from geneSymbol) ENSMUST00000208709.1 uc291ytv.1 uc291ytv.2 uc291ytv.1 uc291ytv.2 
ENSMUST00000208710.2 Ckm ENSMUST00000208710.2 creatine kinase, muscle (from RefSeq NM_007710.2) Ckmm ENSMUST00000208710.1 KCRM_MOUSE NM_007710 P07310 uc009flu.1 uc009flu.2 uc009flu.3 Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Reaction=ATP + creatine = ADP + H(+) + N-phosphocreatine; Xref=Rhea:RHEA:17157, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57947, ChEBI:CHEBI:58092, ChEBI:CHEBI:456216; EC=2.7.3.2; Evidence= Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain. Cytoplasm. Belongs to the ATP:guanido phosphotransferase family. nucleotide binding catalytic activity creatine kinase activity ATP binding extracellular space cytoplasm phosphocreatine metabolic process response to heat kinase activity phosphorylation transferase activity transferase activity, transferring phosphorus-containing groups phosphocreatine biosynthetic process uc009flu.1 uc009flu.2 uc009flu.3 
ENSMUST00000208727.2 9130214F15Rik ENSMUST00000208727.2 9130214F15Rik (from geneSymbol) ENSMUST00000208727.1 uc291yty.1 uc291yty.2 uc291yty.1 uc291yty.2 
ENSMUST00000208742.2 Picalm ENSMUST00000208742.2 phosphatidylinositol binding clathrin assembly protein, transcript variant 11 (from RefSeq NM_001420466.1) Calm ENSMUST00000208742.1 Fit1 NM_001420466 PICAL_MOUSE Q3TS04 Q7M6Y3 Q811P1 Q8BUF6 Q8CIH8 Q8R0A9 Q8R3E1 Q8VDN5 Q921L0 uc009igs.1 uc009igs.2 uc009igs.3 uc009igs.4 Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R- SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF). Binds to clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol 4,5- bisphosphate. Interacts with PIMREG; this interaction may change the subcellular location into the nucleus. Interacts with AP2A1 (via its alpha-appendage domain). Interacts (via N-terminus) with VAMP2; VAMP3; VAMP7 and VAMP8 (Via N- terminus). Interacts with LC3/MAP1LC3A. Cell membrane Membrane, clathrin-coated pit Golgi apparatus Cytoplasmic vesicle, clathrin-coated vesicle Nucleus Note=Colocalized with clathrin in the Golgi area. Interaction with PIMREG may target PICALM to the nucleus in some cells. Event=Alternative splicing; Named isoforms=6; Name=1 ; IsoId=Q7M6Y3-1; Sequence=Displayed; Name=2 ; IsoId=Q7M6Y3-2; Sequence=VSP_050684, VSP_050685, VSP_050686; Name=3 ; IsoId=Q7M6Y3-3; Sequence=VSP_050684, VSP_050685; Name=4 ; IsoId=Q7M6Y3-4; Sequence=VSP_050684; Name=5 ; IsoId=Q7M6Y3-5; Sequence=VSP_050685; Name=6 ; IsoId=Q7M6Y3-6; Sequence=VSP_050686; Skins and livers of 1-week-old mice. PICALM-deficient mice suffer from severe anemia due to ineffective erythropoiesis in the bone marrow. In addition, they exhibit impaired clathrin-mediated internalization of transferrin leading to iron metabolism abnormalities. Belongs to the PICALM/SNAP91 family. Sequence=BAC39454.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; SNARE binding phospholipid binding 1-phosphatidylinositol binding phosphatidylinositol-4,5-bisphosphate binding nucleus endosome early endosome Golgi apparatus plasma membrane clathrin-coated pit endocytosis receptor-mediated endocytosis membrane budding multicellular organism development axonogenesis learning or memory synaptic vesicle cell surface negative regulation of gene expression postsynaptic density membrane synaptic vesicle budding from presynaptic endocytic zone membrane synaptic vesicle maturation vesicle-mediated transport endosomal transport SH3 domain binding Rab GTPase binding hemopoiesis regulation of endocytosis AP-2 adaptor complex clathrin coat of coated pit clathrin-coated vesicle clathrin binding intrinsic component of membrane cytoplasmic vesicle receptor internalization vesicle clathrin heavy chain binding regulation of protein localization cargo loading into vesicle presynaptic membrane identical protein binding neuron projection neuronal cell body intracellular membrane-bounded organelle positive regulation of GTPase activity synapse postsynaptic membrane positive regulation of transcription, DNA-templated tau protein binding negative regulation of receptor-mediated endocytosis clathrin coat assembly synaptic vesicle endocytosis dendrite morphogenesis low-density lipoprotein particle receptor binding positive regulation of axonogenesis regulation of protein transport iron ion homeostasis endosome to plasma membrane transport vesicle clathrin-dependent endocytosis modulation of age-related behavioral decline neurofibrillary tangle regulation of vesicle size postsynapse extrinsic component of presynaptic endocytic zone membrane regulation of synaptic vesicle endocytosis positive regulation of synaptic vesicle endocytosis positive regulation of neuron death positive regulation of beta-amyloid formation regulation of synaptic vesicle transport regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of protein localization to plasma membrane positive regulation of dendrite extension clathrin-coated pit assembly negative regulation of protein localization to cell surface regulation of terminal button organization positive regulation of synaptic vesicle clustering perinuclear region of cytoplasm regulation of beta-amyloid formation uc009igs.1 uc009igs.2 uc009igs.3 uc009igs.4 
ENSMUST00000208745.2 Gm44953 ENSMUST00000208745.2 Gm44953 (from geneSymbol) ENSMUST00000208745.1 uc291teq.1 uc291teq.2 uc291teq.1 uc291teq.2 
ENSMUST00000208748.2 Gm45104 ENSMUST00000208748.2 Gm45104 (from geneSymbol) ENSMUST00000208748.1 uc291mev.1 uc291mev.2 uc291mev.1 uc291mev.2 
ENSMUST00000208757.2 Gm29328 ENSMUST00000208757.2 Gm29328 (from geneSymbol) ENSMUST00000208757.1 uc291rij.1 uc291rij.2 uc291rij.1 uc291rij.2 
ENSMUST00000208758.2 Ankrd31 ENSMUST00000208758.2 ankyrin repeat domain 31 (from RefSeq NM_001370928.1) A0A4W7PWM5 A0A4W7PWM5_MOUSE Ankrd31 ENSMUST00000208758.1 NM_001370928 uc288pii.1 uc288pii.2 uc288pii.1 uc288pii.2 
ENSMUST00000208760.2 Or5b110-ps1 ENSMUST00000208760.2 Or5b110-ps1 (from geneSymbol) ENSMUST00000208760.1 NR_190747 uc289rep.1 uc289rep.2 uc289rep.1 uc289rep.2 
ENSMUST00000208774.2 Gm44866 ENSMUST00000208774.2 Gm44866 (from geneSymbol) ENSMUST00000208774.1 uc291uxy.1 uc291uxy.2 uc291uxy.1 uc291uxy.2 
ENSMUST00000208775.2 Gm45090 ENSMUST00000208775.2 Gm45090 (from geneSymbol) DQ702709 ENSMUST00000208775.1 uc291sbc.1 uc291sbc.2 uc291sbc.1 uc291sbc.2 
ENSMUST00000208780.2 Gm44797 ENSMUST00000208780.2 Gm44797 (from geneSymbol) AK051335 ENSMUST00000208780.1 uc291ybi.1 uc291ybi.2 uc291ybi.1 uc291ybi.2 
ENSMUST00000208781.3 Zfp264 ENSMUST00000208781.3 zinc finger protein 264, transcript variant 1 (from RefSeq NR_183224.1) ENSMUST00000208781.1 ENSMUST00000208781.2 NR_183224 uc009fce.1 uc009fce.2 uc009fce.3 uc009fce.4 uc009fce.1 uc009fce.2 uc009fce.3 uc009fce.4 
ENSMUST00000208787.2 Gm44996 ENSMUST00000208787.2 Gm44996 (from geneSymbol) ENSMUST00000208787.1 uc291slu.1 uc291slu.2 uc291slu.1 uc291slu.2 
ENSMUST00000208788.2 Smim38 ENSMUST00000208788.2 small integral membrane protein 38 (from RefSeq NM_001369202.1) 1810010D01Rik A0A1L1SR87 A0A1L1SR87_MOUSE ENSMUST00000208788.1 NM_001369202 Smim38 uc291xri.1 uc291xri.2 membrane integral component of membrane uc291xri.1 uc291xri.2 
ENSMUST00000208795.2 Gm44982 ENSMUST00000208795.2 Gm44982 (from geneSymbol) ENSMUST00000208795.1 uc291win.1 uc291win.2 uc291win.1 uc291win.2 
ENSMUST00000208799.2 Gm31463 ENSMUST00000208799.2 Gm31463 (from geneSymbol) AK053231 ENSMUST00000208799.1 uc291yai.1 uc291yai.2 uc291yai.1 uc291yai.2 
ENSMUST00000208816.2 Isoc2b ENSMUST00000208816.2 Interacts with CDKN2A. (from UniProt Q9DCC7) AK007698 ENSMUST00000208816.1 ISC2B_MOUSE Isoc2 Q80V19 Q9DCC7 uc291kxc.1 uc291kxc.2 Interacts with CDKN2A. Cytoplasm Nucleus Note=Localizes to the nucleus in the presence of CDKN2A. Ubiquitous. Expressed predominantly in uterus, stomach and urinary tract. Belongs to the isochorismatase family. molecular_function catalytic activity nucleus cytoplasm mitochondrion biological_process uc291kxc.1 uc291kxc.2 
ENSMUST00000208817.2 Gm44891 ENSMUST00000208817.2 Gm44891 (from geneSymbol) ENSMUST00000208817.1 uc291wji.1 uc291wji.2 uc291wji.1 uc291wji.2 
ENSMUST00000208822.2 A330076H08Rik ENSMUST00000208822.2 A330076H08Rik (from geneSymbol) AK080655 ENSMUST00000208822.1 uc009hfb.1 uc009hfb.2 uc009hfb.3 uc009hfb.4 uc009hfb.1 uc009hfb.2 uc009hfb.3 uc009hfb.4 
ENSMUST00000208830.2 Gm44661 ENSMUST00000208830.2 Gm44661 (from geneSymbol) AK030063 ENSMUST00000208830.1 uc057ajh.1 uc057ajh.2 uc057ajh.3 uc057ajh.4 uc057ajh.5 uc057ajh.1 uc057ajh.2 uc057ajh.3 uc057ajh.4 uc057ajh.5 
ENSMUST00000208832.2 Or14j9 ENSMUST00000208832.2 olfactory receptor family 14 subfamily J member 9 (from RefSeq NM_001013575.5) ENSMUST00000208832.1 NM_001013575 Olfr112 Or14j9 Q8C0S2 Q8C0S2_MOUSE uc289kzz.1 uc289kzz.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK016338.1, BY715980.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kzz.1 uc289kzz.2 
ENSMUST00000208833.3 Wdr97 ENSMUST00000208833.3 WD repeat domain 97 (from RefSeq NM_001378250.1) A0A140LHH9 A0A140LHH9_MOUSE ENSMUST00000208833.1 ENSMUST00000208833.2 Gm35339 NM_001378250 Wdr97 uc288zao.1 uc288zao.2 uc288zao.1 uc288zao.2 
ENSMUST00000208842.2 1700019A23Rik ENSMUST00000208842.2 1700019A23Rik (from geneSymbol) AK018838 ENSMUST00000208842.1 uc291nwy.1 uc291nwy.2 uc291nwy.1 uc291nwy.2 
ENSMUST00000208849.2 Gm44832 ENSMUST00000208849.2 Gm44832 (from geneSymbol) ENSMUST00000208849.1 uc291phf.1 uc291phf.2 uc291phf.1 uc291phf.2 
ENSMUST00000208872.3 Gm45145 ENSMUST00000208872.3 Gm45145 (from geneSymbol) ENSMUST00000208872.1 ENSMUST00000208872.2 uc291gbc.1 uc291gbc.2 uc291gbc.3 uc291gbc.1 uc291gbc.2 uc291gbc.3 
ENSMUST00000208874.2 Zp2 ENSMUST00000208874.2 zona pellucida glycoprotein 2, transcript variant 2 (from RefSeq NM_001374631.1) ENSMUST00000208874.1 NM_001374631 Q3UX44 Q3UX44_MOUSE Zp2 uc291uzm.1 uc291uzm.2 This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature polypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK135903.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849377 [ECO:0000350] ##Evidence-Data-END## Cell membrane ; Single-pass type I membrane protein Membrane ; Single-pass type I membrane protein Zona pellucida Belongs to the ZP domain family. ZPA subfamily. extracellular region uc291uzm.1 uc291uzm.2 
ENSMUST00000208875.3 Or5ac25 ENSMUST00000208875.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N1X3) ENSMUST00000208875.1 ENSMUST00000208875.2 L7N1X3 L7N1X3_MOUSE Olfr209 Or5ac25 uc289fgw.1 uc289fgw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289fgw.1 uc289fgw.2 
ENSMUST00000208879.2 Gm44925 ENSMUST00000208879.2 Gm44925 (from geneSymbol) ENSMUST00000208879.1 uc291skd.1 uc291skd.2 uc291skd.1 uc291skd.2 
ENSMUST00000208880.2 Gm45120 ENSMUST00000208880.2 Gm45120 (from geneSymbol) ENSMUST00000208880.1 uc291snc.1 uc291snc.2 uc291snc.1 uc291snc.2 
ENSMUST00000208883.2 9530078K11Rik ENSMUST00000208883.2 9530078K11Rik (from geneSymbol) AK020651 ENSMUST00000208883.1 uc291srz.1 uc291srz.2 uc291srz.1 uc291srz.2 
ENSMUST00000208884.2 Gm45174 ENSMUST00000208884.2 Gm45174 (from geneSymbol) ENSMUST00000208884.1 uc291sey.1 uc291sey.2 uc291sey.1 uc291sey.2 
ENSMUST00000208885.2 Gm44710 ENSMUST00000208885.2 Gm44710 (from geneSymbol) ENSMUST00000208885.1 uc291njv.1 uc291njv.2 uc291njv.1 uc291njv.2 
ENSMUST00000208887.3 Gm44808 ENSMUST00000208887.3 Gm44808 (from geneSymbol) ENSMUST00000208887.1 ENSMUST00000208887.2 uc291rhw.1 uc291rhw.2 uc291rhw.3 uc291rhw.1 uc291rhw.2 uc291rhw.3 
ENSMUST00000208889.2 Gm44535 ENSMUST00000208889.2 Gm44535 (from geneSymbol) AK030150 ENSMUST00000208889.1 uc291rgu.1 uc291rgu.2 uc291rgu.1 uc291rgu.2 
ENSMUST00000208921.4 Cdcp3 ENSMUST00000208921.4 CUB domain containing protein 3, transcript variant 2 (from RefSeq NM_001370825.1) 5430419D17Rik A0A1L1SUH6 A0A1L1SUH6_MOUSE Cdcp3 ENSMUST00000208921.1 ENSMUST00000208921.2 ENSMUST00000208921.3 NM_001370825 uc291whk.1 uc291whk.2 uc291whk.3 Belongs to the DMBT1 family. Lacks conserved residue(s) required for the propagation of feature annotation. scavenger receptor activity endocytosis membrane uc291whk.1 uc291whk.2 uc291whk.3 
ENSMUST00000208924.2 Map6 ENSMUST00000208924.2 Cytoplasm, cytoskeleton (from UniProt A0A140LIT9) A0A140LIT9 A0A140LIT9_MOUSE AK018193 ENSMUST00000208924.1 Map6 uc291syo.1 uc291syo.2 Cytoplasm, cytoskeleton Belongs to the STOP family. microtubule cytoskeleton organization calmodulin binding microtubule microtubule binding uc291syo.1 uc291syo.2 
ENSMUST00000208925.2 Gm39526 ENSMUST00000208925.2 Gm39526 (from geneSymbol) AK085715 ENSMUST00000208925.1 uc292pmc.1 uc292pmc.2 uc292pmc.1 uc292pmc.2 
ENSMUST00000208941.2 Gm44934 ENSMUST00000208941.2 Gm44934 (from geneSymbol) ENSMUST00000208941.1 uc291sxl.1 uc291sxl.2 uc291sxl.1 uc291sxl.2 
ENSMUST00000208946.2 Gm31135 ENSMUST00000208946.2 Gm31135 (from geneSymbol) AK082314 ENSMUST00000208946.1 uc009kuc.1 uc009kuc.2 uc009kuc.1 uc009kuc.2 
ENSMUST00000208948.2 Ect2l ENSMUST00000208948.2 epithelial cell transforming sequence 2 oncogene-like, transcript variant 1 (from RefSeq NM_001370991.1) A0A140LIP2 A0A140LIP2_MOUSE ENSMUST00000208948.1 Ect2l NM_001370991 uc287pud.1 uc287pud.2 molecular_function Rho guanyl-nucleotide exchange factor activity cellular_component biological_process regulation of Rho protein signal transduction uc287pud.1 uc287pud.2 
ENSMUST00000208955.2 Gm9195 ENSMUST00000208955.2 Gm9195 (from geneSymbol) A0A140LHT4 A0A140LHT4_MOUSE ENSMUST00000208955.1 Gm9195 uc288voj.1 uc288voj.2 molecular_function cellular_component extracellular region chitin metabolic process chitin binding biological_process uc288voj.1 uc288voj.2 
ENSMUST00000208963.2 Gm44704 ENSMUST00000208963.2 Gm44704 (from geneSymbol) ENSMUST00000208963.1 uc291slo.1 uc291slo.2 uc291slo.1 uc291slo.2 
ENSMUST00000208965.3 Gm9801 ENSMUST00000208965.3 Gm9801 (from geneSymbol) AK086712 ENSMUST00000208965.1 ENSMUST00000208965.2 uc009hfe.1 uc009hfe.2 uc009hfe.3 uc009hfe.4 uc009hfe.1 uc009hfe.2 uc009hfe.3 uc009hfe.4 
ENSMUST00000208972.2 Gm20744 ENSMUST00000208972.2 predicted gene, 20744 (from RefSeq NR_045744.1) ENSMUST00000208972.1 NR_045744 uc029wmk.1 uc029wmk.2 uc029wmk.1 uc029wmk.2 
ENSMUST00000208973.2 4933431C10Rik ENSMUST00000208973.2 4933431C10Rik (from geneSymbol) AK017001 ENSMUST00000208973.1 uc291lag.1 uc291lag.2 uc291lag.1 uc291lag.2 
ENSMUST00000208974.2 Igsf23 ENSMUST00000208974.2 immunoglobulin superfamily, member 23, transcript variant 3 (from RefSeq NM_001364025.1) A0A140LJ51 A0A140LJ51_MOUSE ENSMUST00000208974.1 Igsf23 NM_001364025 uc012fbk.1 uc012fbk.2 uc012fbk.3 molecular_function cellular_component biological_process membrane integral component of membrane uc012fbk.1 uc012fbk.2 uc012fbk.3 
ENSMUST00000208979.2 Gm35325 ENSMUST00000208979.2 Gm35325 (from geneSymbol) ENSMUST00000208979.1 uc291rgz.1 uc291rgz.2 uc291rgz.1 uc291rgz.2 
ENSMUST00000208983.2 Gm44840 ENSMUST00000208983.2 Gm44840 (from geneSymbol) AK048911 ENSMUST00000208983.1 uc008lnw.1 uc008lnw.2 uc008lnw.3 uc008lnw.1 uc008lnw.2 uc008lnw.3 
ENSMUST00000208993.3 Gm32031 ENSMUST00000208993.3 Gm32031 (from geneSymbol) ENSMUST00000208993.1 ENSMUST00000208993.2 KY468134 uc291qdi.1 uc291qdi.2 uc291qdi.3 uc291qdi.1 uc291qdi.2 uc291qdi.3 
ENSMUST00000208994.2 4933424G06Rik ENSMUST00000208994.2 RIKEN cDNA 4933424G06 gene (from RefSeq NM_001374322.1) 4933424G06Rik A0A140LIP3 A0A140LIP3_MOUSE ENSMUST00000208994.1 NM_001374322 uc287hiy.1 uc287hiy.2 membrane integral component of membrane uc287hiy.1 uc287hiy.2 
ENSMUST00000209007.2 Gm44716 ENSMUST00000209007.2 Gm44716 (from geneSymbol) ENSMUST00000209007.1 LF196786 uc291ydc.1 uc291ydc.2 uc291ydc.1 uc291ydc.2 
ENSMUST00000209009.2 Gm44886 ENSMUST00000209009.2 Gm44886 (from geneSymbol) ENSMUST00000209009.1 uc291rgc.1 uc291rgc.2 uc291rgc.1 uc291rgc.2 
ENSMUST00000209012.2 Gm44610 ENSMUST00000209012.2 Gm44610 (from geneSymbol) DQ565409 ENSMUST00000209012.1 uc291rcc.1 uc291rcc.2 uc291rcc.1 uc291rcc.2 
ENSMUST00000209019.2 Ggn ENSMUST00000209019.2 gametogenetin, transcript variant 4 (from RefSeq NM_001358852.1) ENSMUST00000209019.1 GGN_MOUSE NM_001358852 Q5EBP4 Q80WI9 Q80WJ0 Q80WJ1 uc291npa.1 uc291npa.2 May be involved in spermatogenesis. Isoform 1 and isoform 3 interact with FANCL. Isoform 1 interacts with GGNBP1, ZNF403/GGNBP2 and OAZ3. Isoform 2 interacts with GGNBP1. Q80WJ1; Q5SV77: Ggnbp2; NbExp=3; IntAct=EBI-3890505, EBI-4370069; [Isoform 1]: Cytoplasm, perinuclear region. Note=Localizes along the nuclear membrane. [Isoform 2]: Cytoplasmic vesicle. [Isoform 3]: Nucleus, nucleolus. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=GGN1; IsoId=Q80WJ1-1; Sequence=Displayed; Name=2; Synonyms=GGN2; IsoId=Q80WJ1-2; Sequence=VSP_019172, VSP_019173; Name=3; Synonyms=GGN3; IsoId=Q80WJ1-3; Sequence=VSP_019171; Testis-specific. Specifically expressed in the germ cells and not in the somatic, Sertoli, or Leydig cells. In adult testis, expression starts in stage VIII pachytene spermatocytes, increases in stage IX and X pachytene spermatocytes, and culminates in stage XI diplotene spermatocytes and the meiotic cells in stage XII. Expression decreases slightly in step 1-3 spermatids, further decreases in step 4-11 spermatids, and is no longer detectable in step 12 spermatids and beyond. Isoform 2 is mainly expressed in testis. Isoform 2 is detected at high level in adult testis and at lower level in 19-day testis. Not detected in 14-day testis (at protein level). In the developing postnatal gonad, it is not expressed in 6-day-old testes in which the germ cells are almost exclusively spermatogonia or 14-day testis in which the most advanced germ cells are early pachytene spermatocytes. However, it is expressed in 21-day testis tubules containing late pachytene spermatocytes or spermatids. In the postnatal male testis, it is strictly confined to late pachytene spermatocytes through spermatids, a time during which meiosis takes place. protein binding nucleus nuclear envelope nucleolus cytoplasm double-strand break repair multicellular organism development gamete generation spermatogenesis embryo implantation protein localization integral component of membrane cell differentiation cytoplasmic vesicle ubiquitin protein ligase binding identical protein binding perinuclear region of cytoplasm macromolecular complex assembly uc291npa.1 uc291npa.2 
ENSMUST00000209027.2 1700016B15Rik ENSMUST00000209027.2 1700016B15Rik (from geneSymbol) AK006012 ENSMUST00000209027.1 uc291uvu.1 uc291uvu.2 uc291uvu.1 uc291uvu.2 
ENSMUST00000209028.3 Gm5113 ENSMUST00000209028.3 predicted gene 5113 (from RefSeq NR_157376.1) ENSMUST00000209028.1 ENSMUST00000209028.2 NR_157376 uc009gdo.1 uc009gdo.2 uc009gdo.3 uc009gdo.4 uc009gdo.1 uc009gdo.2 uc009gdo.3 uc009gdo.4 
ENSMUST00000209043.2 Gm36371 ENSMUST00000209043.2 Gm36371 (from geneSymbol) ENSMUST00000209043.1 LF196036 uc291lam.1 uc291lam.2 uc291lam.1 uc291lam.2 
ENSMUST00000209050.2 Gm44948 ENSMUST00000209050.2 Gm44948 (from geneSymbol) ENSMUST00000209050.1 uc291rhd.1 uc291rhd.2 uc291rhd.1 uc291rhd.2 
ENSMUST00000209052.3 Gm45086 ENSMUST00000209052.3 Gm45086 (from geneSymbol) AK139009 ENSMUST00000209052.1 ENSMUST00000209052.2 uc291qfm.1 uc291qfm.2 uc291qfm.3 uc291qfm.1 uc291qfm.2 uc291qfm.3 
ENSMUST00000209063.2 Gm44733 ENSMUST00000209063.2 Gm44733 (from geneSymbol) ENSMUST00000209063.1 uc291laa.1 uc291laa.2 uc291laa.1 uc291laa.2 
ENSMUST00000209064.3 Prss23os ENSMUST00000209064.3 Prss23os (from geneSymbol) AK006119 ENSMUST00000209064.1 ENSMUST00000209064.2 uc009igb.1 uc009igb.2 uc009igb.3 uc009igb.4 uc009igb.1 uc009igb.2 uc009igb.3 uc009igb.4 
ENSMUST00000209073.2 Gm45166 ENSMUST00000209073.2 Gm45166 (from geneSymbol) AK157229 ENSMUST00000209073.1 uc291ytq.1 uc291ytq.2 uc291ytq.1 uc291ytq.2 
ENSMUST00000209080.3 Gm44761 ENSMUST00000209080.3 Gm44761 (from geneSymbol) ENSMUST00000209080.1 ENSMUST00000209080.2 uc291ybq.1 uc291ybq.2 uc291ybq.3 uc291ybq.1 uc291ybq.2 uc291ybq.3 
ENSMUST00000209081.2 Gm10623 ENSMUST00000209081.2 Gm10623 (from geneSymbol) ENSMUST00000209081.1 uc291rct.1 uc291rct.2 uc291rct.1 uc291rct.2 
ENSMUST00000209083.2 Gm44688 ENSMUST00000209083.2 Gm44688 (from geneSymbol) ENSMUST00000209083.1 uc291riy.1 uc291riy.2 uc291riy.1 uc291riy.2 
ENSMUST00000209091.2 Gm45074 ENSMUST00000209091.2 Gm45074 (from geneSymbol) AK032889 ENSMUST00000209091.1 uc291yam.1 uc291yam.2 uc291yam.1 uc291yam.2 
ENSMUST00000209095.2 Umod ENSMUST00000209095.2 uromodulin, transcript variant 2 (from RefSeq NM_001278605.1) ENSMUST00000209095.1 NM_001278605 Q3TN64 Q3TP60 Q62285 Q91X17 UROM_MOUSE uc009jlc.1 uc009jlc.2 uc009jlc.3 uc009jlc.4 This gene encodes a glycoprotein that is the most abundant protein in mammalian urine under physiological conditions. It is synthesized in the kidney as a glycosyl-phosphatidylinositol anchored protein and released into urine as a soluble form by proteolytic cleavage. It is thought to regulate water and salt balance in the thick ascending limb of Henle and to protect against urinary tract infection and calcium oxalate crystal formation. In mouse deficiency of this gene is associated with increased susceptibility to bacterial infections and formation of calcium crystals in kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. [Uromodulin, secreted form]: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals (PubMed:14871399, PubMed:15327412). Protects against urinary tract infections by binding to type 1 fimbriated E.coli (PubMed:11134021). Binds to the bacterial adhesin fimH which mediates the stable formation of bacterial aggregates, prevents the binding of E.coli to uroplakins UPK1A and UPK1B which act as urothelial receptors for type I fimbriae, and allows for pathogen clearance through micturation (By similarity). Also promotes aggregation of other bacteria including K.pneumoniae, P.aeruginosa and S.mitis and so may also protect against other uropathogens (By similarity). [Uromodulin, secreted form]: Homodimer that then polymerizes into long filaments (PubMed:26673890). The filaments can additionally assemble laterally to form a sheet (By similarity). The filaments consist of a zigzag-shaped backbone with laterally protruding arms which interact with bacterial adhesin fimH (By similarity). Two fimH molecules can bind to a single UMOD monomer (By similarity). [Uromodulin, secreted form]: Secreted Note=Detected in urine. Apical cell membrane ; Lipid-anchor, GPI-anchor Basolateral cell membrane ; Lipid-anchor, GPI-anchor Cell projection, cilium membrane Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization. Secreted into urine after cleavage. Colocalizes with NPHP1 and KIF3A. Detected in urine (secreted form). Detected in kidney thick ascending limb epithelial cells (at protein level). The ZP domain mediates polymerization, leading to the formation of long filaments (PubMed:12021773, PubMed:26673890). The core of the filament consists of interlocked ZP domains which assemble into a helical structure. Each ZP domain consists of an N-terminal (ZP-N) and C-terminal (ZP-C) region connected by a flexible linker; the linker allows the ZP domain to wrap around the ZP-C subdomain of the preceding subunit. The heavily glycosylated N-terminal part of the protein (containing several EGF-like domains) forms branches which protrude from the core and are be involved in pathogen capture (By similarity). N-glycosylated. Proteolytically cleaved at a conserved C-terminal proteolytic cleavage site to generate the secreted form found in urine (PubMed:18375198). This cleavage is catalyzed by HPN (PubMed:26673890). Mice suffer significantly more frequently from urinary tract infections. They shown also spontaneous formation of calcium crystals in adult kidneys, and excessive intake of calcium and oxalate dramatically increases both the frequency and the severity of renal calcium crystal formation in mutant mice, but not in wild-type mice. spindle pole calcium ion binding extracellular region extracellular space Golgi apparatus plasma membrane cilium heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion excretion membrane basolateral plasma membrane apical plasma membrane IgG binding anchored component of membrane cytoplasmic vesicle cell projection membrane raft apical part of cell chemical homeostasis ion homeostasis ciliary membrane metanephric ascending thin limb development metanephric distal convoluted tubule development metanephric thick ascending limb development neutrophil migration uc009jlc.1 uc009jlc.2 uc009jlc.3 uc009jlc.4 
ENSMUST00000209099.2 U2af2 ENSMUST00000209099.2 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2, transcript variant 10 (from RefSeq NM_001403153.1) ENSMUST00000209099.1 NM_001403153 P26369 U2AF2_MOUSE U2af65 uc009ezu.1 uc009ezu.2 uc009ezu.3 uc009ezu.4 uc009ezu.5 Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals. Interacts with U2AF1L4 (PubMed:16819553). Heterodimer with U2AF1. Binds unphosphorylated SF1. Interacts with SCAF11 and SNW1. Interacts with ZRSR2/U2AF1-RS2. Interacts with RBM17. Interacts with PRPF19; the interaction is direct. Interacts with POLR2A (via the C- terminal domain); Interacts with PRPF19; the interaction is direct. Interacts with POLR2A (via the C-terminal domain); recruits PRPF19 and the Prp19 complex to the pre-mRNA. Interacts with KHDC4 (Isoform 2). Interacts with ZRSR2. Interacts with the SF3B complex composed of SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6 and PHF5A (By similarity). Interacts (via N-terminus) with CPSF7 (via C-terminus); this interaction stimulates pre-mRNA 3'-end processing by promoting the recruitment of the CFIm complex to cleavage and polyadenylation signals (By similarity). P26369; Q15637: SF1; Xeno; NbExp=3; IntAct=EBI-8321355, EBI-744603; Nucleus. Lysyl-hydroxylation at Lys-15 and Lys-276 affects the mRNA splicing activity of the protein, leading to regulate some, but not all, alternative splicing events. Belongs to the splicing factor SR family. Sequence=CAA45875.1; Type=Erroneous initiation; Evidence=; commitment complex mRNA splicing, via spliceosome Prp19 complex nucleic acid binding RNA binding protein binding nucleus spliceosomal complex mRNA processing poly-pyrimidine tract binding RNA splicing nuclear speck enzyme binding pre-mRNA 3'-splice site binding negative regulation of protein ubiquitination positive regulation of RNA splicing negative regulation of mRNA splicing, via spliceosome C2H2 zinc finger domain binding U2-type prespliceosome U2AF uc009ezu.1 uc009ezu.2 uc009ezu.3 uc009ezu.4 uc009ezu.5 
ENSMUST00000209101.3 Gm15396 ENSMUST00000209101.3 Gm15396 (from geneSymbol) AK131623 ENSMUST00000209101.1 ENSMUST00000209101.2 uc291pgy.1 uc291pgy.2 uc291pgy.3 uc291pgy.1 uc291pgy.2 uc291pgy.3 
ENSMUST00000209104.2 Gm45177 ENSMUST00000209104.2 Gm45177 (from geneSymbol) ENSMUST00000209104.1 uc291spw.1 uc291spw.2 uc291spw.1 uc291spw.2 
ENSMUST00000209111.4 2310016G11Rik ENSMUST00000209111.4 RIKEN cDNA 2310016G11 gene (from RefSeq NR_152106.1) ENSMUST00000209111.1 ENSMUST00000209111.2 ENSMUST00000209111.3 NR_152106 uc291phq.1 uc291phq.2 uc291phq.3 uc291phq.4 uc291phq.1 uc291phq.2 uc291phq.3 uc291phq.4 
ENSMUST00000209114.2 Gm34821 ENSMUST00000209114.2 Gm34821 (from geneSymbol) ENSMUST00000209114.1 uc291tbs.1 uc291tbs.2 uc291tbs.1 uc291tbs.2 
ENSMUST00000209117.2 Zfand6 ENSMUST00000209117.2 zinc finger, AN1-type domain 6, transcript variant 7 (from RefSeq NM_001360582.1) Awp1 ENSMUST00000209117.1 NM_001360582 Q9DCH6 Q9ER79 ZFAN6_MOUSE Za20d3 uc009iem.1 uc009iem.2 uc009iem.3 Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1 (By similarity). Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes. Interacts with PKN1. Interacts with TRAF2 (By similarity). Interacts with mono- and polyubiquitin. Interacts with PEX6. Interacts with PEX5 (Cys-linked ubiquitinated). Cytoplasm The A20-type zinc finger domain mediates regulation of NF- kappa-B activity. The AN1-type zinc finger domain mediates association with TRAF2. DNA binding protein binding cytoplasm protein targeting to peroxisome apoptotic process zinc ion binding protein transport polyubiquitin binding negative regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling metal ion binding cellular response to tumor necrosis factor uc009iem.1 uc009iem.2 uc009iem.3 
ENSMUST00000209119.2 Gm44888 ENSMUST00000209119.2 Gm44888 (from geneSymbol) ENSMUST00000209119.1 uc291rfp.1 uc291rfp.2 uc291rfp.1 uc291rfp.2 
ENSMUST00000209120.2 Gm44811 ENSMUST00000209120.2 Gm44811 (from geneSymbol) ENSMUST00000209120.1 uc291rhq.1 uc291rhq.2 uc291rhq.1 uc291rhq.2 
ENSMUST00000209122.2 Gm44617 ENSMUST00000209122.2 Gm44617 (from geneSymbol) AK028547 ENSMUST00000209122.1 uc291nlb.1 uc291nlb.2 uc291nlb.1 uc291nlb.2 
ENSMUST00000209142.2 Gm45807 ENSMUST00000209142.2 Gm45807 (from geneSymbol) AK088442 ENSMUST00000209142.1 uc009idh.1 uc009idh.2 uc009idh.1 uc009idh.2 
ENSMUST00000209149.3 Gm32850 ENSMUST00000209149.3 Gm32850 (from geneSymbol) ENSMUST00000209149.1 ENSMUST00000209149.2 uc291sbb.1 uc291sbb.2 uc291sbb.3 uc291sbb.1 uc291sbb.2 uc291sbb.3 
ENSMUST00000209151.2 Gm44677 ENSMUST00000209151.2 Gm44677 (from geneSymbol) ENSMUST00000209151.1 uc291sqf.1 uc291sqf.2 uc291sqf.1 uc291sqf.2 
ENSMUST00000209154.3 Dnah3 ENSMUST00000209154.3 dynein, axonemal, heavy chain 3 (from RefSeq NM_001370806.1) A0A140LIN9 A0A140LIN9_MOUSE Dnah3 ENSMUST00000209154.1 ENSMUST00000209154.2 NM_001370806 uc291uzd.1 uc291uzd.2 Belongs to the dynein heavy chain family. microtubule motor activity ATP binding microtubule-based movement dynein complex uc291uzd.1 uc291uzd.2 
ENSMUST00000209160.2 Gm39059 ENSMUST00000209160.2 Gm39059 (from geneSymbol) ENSMUST00000209160.1 uc291tdo.1 uc291tdo.2 uc291tdo.1 uc291tdo.2 
ENSMUST00000209173.2 Gm44842 ENSMUST00000209173.2 Gm44842 (from geneSymbol) AK032428 ENSMUST00000209173.1 uc291xzl.1 uc291xzl.2 uc291xzl.1 uc291xzl.2 
ENSMUST00000209181.2 Gm45039 ENSMUST00000209181.2 Gm45039 (from geneSymbol) ENSMUST00000209181.1 uc291sso.1 uc291sso.2 uc291sso.1 uc291sso.2 
ENSMUST00000209183.2 Gm44620 ENSMUST00000209183.2 Gm44620 (from geneSymbol) ENSMUST00000209183.1 LF196849 uc291ytx.1 uc291ytx.2 uc291ytx.1 uc291ytx.2 
ENSMUST00000209192.3 Or9i16 ENSMUST00000209192.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFQ4) A0A140LHZ3 ENSMUST00000209192.1 ENSMUST00000209192.2 Olfr1504 Or9i16 Q8VFQ4 Q8VFQ4_MOUSE uc008gwh.1 uc008gwh.2 uc008gwh.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gwh.1 uc008gwh.2 uc008gwh.3 
ENSMUST00000209194.3 Gm57249 ENSMUST00000209194.3 Gm57249 (from geneSymbol) ENSMUST00000209194.1 ENSMUST00000209194.2 uc291nmc.1 uc291nmc.2 uc291nmc.3 uc291nmc.1 uc291nmc.2 uc291nmc.3 
ENSMUST00000209208.2 Gm19935 ENSMUST00000209208.2 predicted gene, 19935 (from RefSeq NR_157160.1) A0A1B0GSF9 A0A1B0GSF9_MOUSE ENSMUST00000209208.1 Gm19935 NR_157160 uc009msd.1 uc009msd.2 uc009msd.3 uc009msd.1 uc009msd.2 uc009msd.3 
ENSMUST00000209210.3 Gm6329 ENSMUST00000209210.3 predicted gene 6329 (from RefSeq NR_040690.1) ENSMUST00000209210.1 ENSMUST00000209210.2 NR_040690 uc009lor.1 uc009lor.2 uc009lor.3 uc009lor.4 uc009lor.1 uc009lor.2 uc009lor.3 uc009lor.4 
ENSMUST00000209217.2 Gm45259 ENSMUST00000209217.2 Gm45259 (from geneSymbol) ENSMUST00000209217.1 uc291zwc.1 uc291zwc.2 uc291zwc.1 uc291zwc.2 
ENSMUST00000209234.2 Gm45326 ENSMUST00000209234.2 Gm45326 (from geneSymbol) ENSMUST00000209234.1 uc292bfq.1 uc292bfq.2 uc292bfq.1 uc292bfq.2 
ENSMUST00000209240.2 Gm45394 ENSMUST00000209240.2 Gm45394 (from geneSymbol) ENSMUST00000209240.1 uc291ynf.1 uc291ynf.2 uc291ynf.1 uc291ynf.2 
ENSMUST00000209244.2 Pkhd1l1 ENSMUST00000209244.2 polycystic kidney and hepatic disease 1-like 1 (from RefSeq NM_138674.3) ENSMUST00000209244.1 NM_138674 PKHL1_MOUSE Q80ZA4 Q99PS9 uc007vpy.1 uc007vpy.2 uc007vpy.3 uc007vpy.4 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80ZA4-1; Sequence=Displayed; Name=2; IsoId=Q80ZA4-2; Sequence=VSP_031226, VSP_031227; molecular_function protein binding cilium biological_process membrane integral component of membrane uc007vpy.1 uc007vpy.2 uc007vpy.3 uc007vpy.4 
ENSMUST00000209248.2 Rnf223 ENSMUST00000209248.2 ring finger 223 (from RefSeq NM_001220499.3) A0A1B0GR81 A0A1B0GR81_MOUSE ENSMUST00000209248.1 NM_001220499 Rnf223 uc057llf.1 uc057llf.2 uc057llf.3 membrane integral component of membrane metal ion binding uc057llf.1 uc057llf.2 uc057llf.3 
ENSMUST00000209267.2 Gm45286 ENSMUST00000209267.2 Gm45286 (from geneSymbol) AK034530 ENSMUST00000209267.1 uc292bej.1 uc292bej.2 uc292bej.1 uc292bej.2 
ENSMUST00000209271.3 Gm45540 ENSMUST00000209271.3 Gm45540 (from geneSymbol) ENSMUST00000209271.1 ENSMUST00000209271.2 uc291zyl.1 uc291zyl.2 uc291zyl.1 uc291zyl.2 
ENSMUST00000209295.2 Gm45659 ENSMUST00000209295.2 Gm45659 (from geneSymbol) ENSMUST00000209295.1 uc291znr.1 uc291znr.2 uc291znr.1 uc291znr.2 
ENSMUST00000209296.3 Or5p78 ENSMUST00000209296.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRU6) ENSMUST00000209296.1 ENSMUST00000209296.2 Olfr506 Or5p78 Q7TRU6 Q7TRU6_MOUSE uc009jcp.1 uc009jcp.2 uc009jcp.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jcp.1 uc009jcp.2 uc009jcp.3 
ENSMUST00000209298.2 Gm45508 ENSMUST00000209298.2 Gm45508 (from geneSymbol) ENSMUST00000209298.1 uc291max.1 uc291max.2 uc291max.1 uc291max.2 
ENSMUST00000209302.2 4933421D24Rik ENSMUST00000209302.2 4933421D24Rik (from geneSymbol) AK016858 ENSMUST00000209302.1 uc292beb.1 uc292beb.2 uc292beb.1 uc292beb.2 
ENSMUST00000209303.2 Gm36843 ENSMUST00000209303.2 Gm36843 (from geneSymbol) ENSMUST00000209303.1 uc292car.1 uc292car.2 uc292car.1 uc292car.2 
ENSMUST00000209312.3 Gm32389 ENSMUST00000209312.3 Gm32389 (from geneSymbol) ENSMUST00000209312.1 ENSMUST00000209312.2 uc291zba.1 uc291zba.2 uc291zba.3 uc291zba.1 uc291zba.2 uc291zba.3 
ENSMUST00000209325.2 Gm45844 ENSMUST00000209325.2 Cell membrane ; Multi-pass membrane protein (from UniProt A0A1B0GRA1) A0A1B0GRA1 A0A1B0GRA1_MOUSE AK046541 ENSMUST00000209325.1 Gm45844 uc291leh.1 uc291leh.2 Cell membrane ; Multi-pass membrane protein G-protein coupled receptor activity G-protein coupled receptor signaling pathway integral component of membrane uc291leh.1 uc291leh.2 
ENSMUST00000209328.2 Ifitm6 ENSMUST00000209328.2 Belongs to the CD225/Dispanin family. (from UniProt Q3SXF0) AK039626 ENSMUST00000209328.1 Ifitm6 Q3SXF0 Q3SXF0_MOUSE uc291wyf.1 uc291wyf.2 Belongs to the CD225/Dispanin family. molecular_function plasma membrane membrane integral component of membrane response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication negative regulation of viral entry into host cell defense response to virus type I interferon signaling pathway uc291wyf.1 uc291wyf.2 
ENSMUST00000209330.3 Gm35363 ENSMUST00000209330.3 Gm35363 (from geneSymbol) AK158044 ENSMUST00000209330.1 ENSMUST00000209330.2 uc291ths.1 uc291ths.2 uc291ths.3 uc291ths.1 uc291ths.2 uc291ths.3 
ENSMUST00000209340.2 Gm45552 ENSMUST00000209340.2 Gm45552 (from geneSymbol) ENSMUST00000209340.1 uc291poj.1 uc291poj.2 uc291poj.1 uc291poj.2 
ENSMUST00000209359.3 Gm50169 ENSMUST00000209359.3 Gm50169 (from geneSymbol) AK029127 ENSMUST00000209359.1 ENSMUST00000209359.2 uc289pkz.1 uc289pkz.2 uc289pkz.3 uc289pkz.1 uc289pkz.2 uc289pkz.3 
ENSMUST00000209360.2 Gm44992 ENSMUST00000209360.2 Gm44992 (from geneSymbol) ENSMUST00000209360.1 uc291ota.1 uc291ota.2 uc291ota.1 uc291ota.2 
ENSMUST00000209367.2 Gm45579 ENSMUST00000209367.2 Gm45579 (from geneSymbol) ENSMUST00000209367.1 uc290pmw.1 uc290pmw.2 uc290pmw.1 uc290pmw.2 
ENSMUST00000209370.2 Svet1 ENSMUST00000209370.2 Svet1 (from geneSymbol) ENSMUST00000209370.1 uc291zdl.1 uc291zdl.2 uc291zdl.1 uc291zdl.2 
ENSMUST00000209382.3 Csnka2ip ENSMUST00000209382.3 casein kinase 2, alpha prime interacting protein, transcript variant 1 (from RefSeq NM_173861.3) A0A1B0GSC5 CKT2 CS2IP_MOUSE Csnka2ip ENSMUST00000209382.1 ENSMUST00000209382.2 NM_173861 Q8CH19 uc012aha.1 uc012aha.2 uc012aha.3 uc012aha.4 May play a role in chromatin regulation of male germ cells. Interacts (via C-terminus) with CSNK2A2. Nucleus Note=Present in nuclei of spermatids during chromatin condensation. Expressed exclusively in testis (at protein level). Within testis, expressed mainly in the intermediate compartment of the seminiferous tubules with weaker expression in the basal and adluminal compartments. Phosphorylated by CK2 (casein kinase II), specifically by complexes containing catalytic subunit CSNK2A2. Sequence=AAI37819.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAO15676.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=EDK98240.1; Type=Erroneous gene model prediction; Evidence=; protein binding nucleus biological_process uc012aha.1 uc012aha.2 uc012aha.3 uc012aha.4 
ENSMUST00000209384.2 Gm45558 ENSMUST00000209384.2 Gm45558 (from geneSymbol) ENSMUST00000209384.1 EU234043 uc291twn.1 uc291twn.2 uc291twn.1 uc291twn.2 
ENSMUST00000209385.2 Gm34370 ENSMUST00000209385.2 Gm34370 (from geneSymbol) ENSMUST00000209385.1 uc292acg.1 uc292acg.2 uc292acg.1 uc292acg.2 
ENSMUST00000209393.2 Gm45426 ENSMUST00000209393.2 Gm45426 (from geneSymbol) AK140065 ENSMUST00000209393.1 uc291woi.1 uc291woi.2 uc291woi.1 uc291woi.2 
ENSMUST00000209402.3 Gm45847 ENSMUST00000209402.3 Gm45847 (from geneSymbol) AK140221 ENSMUST00000209402.1 ENSMUST00000209402.2 uc291vfi.1 uc291vfi.2 uc291vfi.3 uc291vfi.1 uc291vfi.2 uc291vfi.3 
ENSMUST00000209408.4 Or10k2 ENSMUST00000209408.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q848) E9Q848 E9Q848_MOUSE ENSMUST00000209408.1 ENSMUST00000209408.2 ENSMUST00000209408.3 Olfr370 Or10k2 uc292bkd.1 uc292bkd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292bkd.1 uc292bkd.2 
ENSMUST00000209414.2 Gm45250 ENSMUST00000209414.2 Gm45250 (from geneSymbol) ENSMUST00000209414.1 uc291yzx.1 uc291yzx.2 uc291yzx.1 uc291yzx.2 
ENSMUST00000209418.2 Gm20100 ENSMUST00000209418.2 Gm20100 (from geneSymbol) ENSMUST00000209418.1 LF204636 uc291ydg.1 uc291ydg.2 uc291ydg.1 uc291ydg.2 
ENSMUST00000209421.2 Best2 ENSMUST00000209421.2 bestrophin 2, transcript variant 2 (from RefSeq NR_052011.1) A0A0R4J0P0 A0A0R4J0P0_MOUSE Best2 ENSMUST00000209421.1 NR_052011 uc009mow.1 uc009mow.2 uc009mow.3 uc009mow.4 uc009mow.5 Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily. chloride channel activity plasma membrane ion transport chloride transport membrane integral component of membrane chloride channel complex chloride transmembrane transport uc009mow.1 uc009mow.2 uc009mow.3 uc009mow.4 uc009mow.5 
ENSMUST00000209422.2 Rtp4 ENSMUST00000209422.2 Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (By similarity). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (PubMed:18836069). (from UniProt Q9ER80) AK018021 ENSMUST00000209422.1 Ifrg28 Q9D3D6 Q9ER80 RTP4_MOUSE uc289duh.1 uc289duh.2 Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (By similarity). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (PubMed:18836069). Interacts with TASR16 (By similarity). Interacts with OPRD1 and OPRM1; the interaction promotes cell surface localization of the OPDR1-OPRM1 heterodimer (PubMed:18836069). Q9ER80; P32300: Oprd1; NbExp=2; IntAct=EBI-15731539, EBI-2615936; Membrane ; Single-pass type III membrane protein Expressed at low levels in olfactory neurons. By interferons. Belongs to the TMEM7 family. detection of chemical stimulus involved in sensory perception of bitter taste protein binding cytoplasm protein targeting to membrane membrane integral component of membrane olfactory receptor binding protein insertion into membrane defense response to virus uc289duh.1 uc289duh.2 
ENSMUST00000209427.2 5430430B14Rik ENSMUST00000209427.2 5430430B14Rik (from geneSymbol) AK017364 ENSMUST00000209427.1 uc291zct.1 uc291zct.2 uc291zct.1 uc291zct.2 
ENSMUST00000209434.3 Gm45682 ENSMUST00000209434.3 Gm45682 (from geneSymbol) ENSMUST00000209434.1 ENSMUST00000209434.2 uc291wpf.1 uc291wpf.2 uc291wpf.3 uc291wpf.1 uc291wpf.2 uc291wpf.3 
ENSMUST00000209455.3 E330018M18Rik ENSMUST00000209455.3 E330018M18Rik (from geneSymbol) AK141748 ENSMUST00000209455.1 ENSMUST00000209455.2 uc009lqu.1 uc009lqu.2 uc009lqu.3 uc009lqu.1 uc009lqu.2 uc009lqu.3 
ENSMUST00000209467.2 Gm45713 ENSMUST00000209467.2 Belongs to the universal ribosomal protein uL13 family. (from UniProt A0A1B0GS68) A0A1B0GS68 A0A1B0GS68_MOUSE ENSMUST00000209467.1 Gm45713 KY499699 uc057lty.1 uc057lty.2 uc057lty.3 Belongs to the universal ribosomal protein uL13 family. mRNA binding structural constituent of ribosome cytokine activity ribosome translation signal transduction large ribosomal subunit membrane integral component of membrane negative regulation of translation cytosolic large ribosomal subunit uc057lty.1 uc057lty.2 uc057lty.3 
ENSMUST00000209469.2 Cfl1 ENSMUST00000209469.2 cofilin 1, non-muscle (from RefSeq NM_007687.5) Cfl1 ENSMUST00000209469.1 NM_007687 Q544Y7 Q544Y7_MOUSE uc008gdq.1 uc008gdq.2 uc008gdq.3 uc008gdq.4 Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side Belongs to the actin-binding proteins ADF family. actin binding cytoplasm focal adhesion cytoskeleton organization response to virus actin cytoskeleton regulation of cell morphogenesis actin filament depolymerization positive regulation by host of viral process actin filament binding regulation of dendritic spine morphogenesis uc008gdq.1 uc008gdq.2 uc008gdq.3 uc008gdq.4 
ENSMUST00000209473.4 Or51q1 ENSMUST00000209473.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRQ3) ENSMUST00000209473.1 ENSMUST00000209473.2 ENSMUST00000209473.3 Olfr635 Or51q1 Q7TRQ3 Q7TRQ3_MOUSE uc291tsj.1 uc291tsj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tsj.1 uc291tsj.2 
ENSMUST00000209485.2 Gm18190 ENSMUST00000209485.2 Gm18190 (from geneSymbol) AK084962 ENSMUST00000209485.1 uc291leo.1 uc291leo.2 uc291leo.1 uc291leo.2 
ENSMUST00000209486.2 Gm45251 ENSMUST00000209486.2 Gm45251 (from geneSymbol) AK037384 ENSMUST00000209486.1 uc291yzw.1 uc291yzw.2 uc291yzw.1 uc291yzw.2 
ENSMUST00000209492.2 Gm45358 ENSMUST00000209492.2 Gm45358 (from geneSymbol) ENSMUST00000209492.1 uc292abi.1 uc292abi.2 uc292abi.1 uc292abi.2 
ENSMUST00000209493.2 Gm6658 ENSMUST00000209493.2 predicted gene 6658 (from RefSeq NR_188717.1) ENSMUST00000209493.1 NR_188717 uc292byg.1 uc292byg.2 uc292byg.1 uc292byg.2 
ENSMUST00000209494.2 Gm45493 ENSMUST00000209494.2 Gm45493 (from geneSymbol) ENSMUST00000209494.1 LF196815 uc291ynt.1 uc291ynt.2 uc291ynt.1 uc291ynt.2 
ENSMUST00000209497.3 Misfadt ENSMUST00000209497.3 Misfadt (from geneSymbol) AK135845 ENSMUST00000209497.1 ENSMUST00000209497.2 uc009gzt.1 uc009gzt.2 uc009gzt.3 uc009gzt.4 uc009gzt.1 uc009gzt.2 uc009gzt.3 uc009gzt.4 
ENSMUST00000209499.2 Gm45407 ENSMUST00000209499.2 Gm45407 (from geneSymbol) ENSMUST00000209499.1 uc292bed.1 uc292bed.2 uc292bed.1 uc292bed.2 
ENSMUST00000209502.2 Gm33594 ENSMUST00000209502.2 Gm33594 (from geneSymbol) ENSMUST00000209502.1 uc289wfe.1 uc289wfe.2 uc289wfe.1 uc289wfe.2 
ENSMUST00000209505.2 Zfp143 ENSMUST00000209505.2 Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity). (from UniProt O70230) AK029926 ENSMUST00000209505.1 O70230 Q8BGB0 Q8CEI6 Q8CI27 Staf ZN143_MOUSE Znf143 uc291ukn.1 uc291ukn.2 Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity). Interacts with CHD8. O70230; Q8BX22: Sall4; NbExp=2; IntAct=EBI-5691478, EBI-2312582; Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O70230-1; Sequence=Displayed; Name=2; IsoId=O70230-2; Sequence=VSP_036980; Name=3; IsoId=O70230-3; Sequence=VSP_036979; Belongs to the GLI C2H2-type zinc-finger protein family. Sequence=AAC16899.1; Type=Erroneous initiation; Evidence=; Sequence=AAH37658.1; Type=Erroneous initiation; Evidence=; Sequence=BAC25726.1; Type=Frameshift; Evidence=; Sequence=BAC26281.1; Type=Erroneous initiation; Evidence=; Sequence=CAC17144.1; Type=Erroneous initiation; Evidence=; nuclear chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding chromatin binding protein binding nucleus transcription factor complex PcG protein complex sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding positive regulation of smooth muscle cell proliferation uc291ukn.1 uc291ukn.2 
ENSMUST00000209524.2 7420700N18Rik ENSMUST00000209524.2 RIKEN cDNA 7420700N18 gene (from RefSeq NR_046272.1) ENSMUST00000209524.1 NR_046272 uc291zeh.1 uc291zeh.2 uc291zeh.1 uc291zeh.2 
ENSMUST00000209528.3 Or51b6 ENSMUST00000209528.3 olfactory receptor family 51 subfamily B member 6 (from RefSeq NM_013616.4) A0A1B0GSF4 A0A1B0GSF4_MOUSE ENSMUST00000209528.1 ENSMUST00000209528.2 NM_013616 Olfr65 Or51b6 uc012fre.1 uc012fre.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC137766.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc012fre.1 uc012fre.2 
ENSMUST00000209529.2 B930086L07Rik ENSMUST00000209529.2 B930086L07Rik (from geneSymbol) ENSMUST00000209529.1 uc291wli.1 uc291wli.2 uc291wli.1 uc291wli.2 
ENSMUST00000209541.2 Gm10252 ENSMUST00000209541.2 Gm10252 (from geneSymbol) AK158602 ENSMUST00000209541.1 uc291ptv.1 uc291ptv.2 uc291ptv.1 uc291ptv.2 
ENSMUST00000209549.2 Gm45276 ENSMUST00000209549.2 Gm45276 (from geneSymbol) ENSMUST00000209549.1 uc291ymc.1 uc291ymc.2 uc291ymc.1 uc291ymc.2 
ENSMUST00000209552.2 Gm32507 ENSMUST00000209552.2 Gm32507 (from geneSymbol) ENSMUST00000209552.1 uc292agc.1 uc292agc.2 uc292agc.1 uc292agc.2 
ENSMUST00000209554.3 Gm35368 ENSMUST00000209554.3 Gm35368 (from geneSymbol) ENSMUST00000209554.1 ENSMUST00000209554.2 uc292aez.1 uc292aez.2 uc292aez.3 uc292aez.1 uc292aez.2 uc292aez.3 
ENSMUST00000209558.2 A730009L09Rik ENSMUST00000209558.2 A730009L09Rik (from geneSymbol) AK042603 ENSMUST00000209558.1 uc289fry.1 uc289fry.2 uc289fry.1 uc289fry.2 
ENSMUST00000209560.2 C230079O03Rik ENSMUST00000209560.2 RIKEN cDNA C230079O03 gene (from RefSeq NR_040459.1) ENSMUST00000209560.1 NR_040459 uc029wpc.1 uc029wpc.2 uc029wpc.1 uc029wpc.2 
ENSMUST00000209561.3 Gm45502 ENSMUST00000209561.3 Gm45502 (from geneSymbol) ENSMUST00000209561.1 ENSMUST00000209561.2 uc291wkm.1 uc291wkm.2 uc291wkm.3 uc291wkm.1 uc291wkm.2 uc291wkm.3 
ENSMUST00000209572.2 Gm45427 ENSMUST00000209572.2 Gm45427 (from geneSymbol) ENSMUST00000209572.1 uc292bzw.1 uc292bzw.2 uc292bzw.1 uc292bzw.2 
ENSMUST00000209585.2 1700015I17Rik ENSMUST00000209585.2 1700015I17Rik (from geneSymbol) ENSMUST00000209585.1 uc291zim.1 uc291zim.2 uc291zim.1 uc291zim.2 
ENSMUST00000209595.2 Gm15802 ENSMUST00000209595.2 Gm15802 (from geneSymbol) ENSMUST00000209595.1 uc289eqx.1 uc289eqx.2 uc289eqx.1 uc289eqx.2 
ENSMUST00000209599.2 Krtap5-22 ENSMUST00000209599.2 Krtap5-22 (from geneSymbol) A0A1B0GT06 A0A1B0GT06_MOUSE ENSMUST00000209599.1 Gm29735 uc291xhk.1 uc291xhk.2 intermediate filament keratin filament uc291xhk.1 uc291xhk.2 
ENSMUST00000209605.2 Gm45592 ENSMUST00000209605.2 Gm45592 (from geneSymbol) AK085930 ENSMUST00000209605.1 uc291yeh.1 uc291yeh.2 uc291yeh.1 uc291yeh.2 
ENSMUST00000209617.2 Lmtk3 ENSMUST00000209617.2 Lmtk3 (from geneSymbol) A0A1B0GSR5 A0A1B0GSR5_MOUSE BC059845 ENSMUST00000209617.1 Lmtk3 uc009gxd.1 uc009gxd.2 uc009gxd.3 uc009gxd.4 uc009gxd.5 protein kinase activity ATP binding protein phosphorylation membrane integral component of membrane uc009gxd.1 uc009gxd.2 uc009gxd.3 uc009gxd.4 uc009gxd.5 
ENSMUST00000209619.2 Gm45428 ENSMUST00000209619.2 Gm45428 (from geneSymbol) ENSMUST00000209619.1 uc057amm.1 uc057amm.2 uc057amm.1 uc057amm.2 
ENSMUST00000209620.4 Or10a3m ENSMUST00000209620.4 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRU5) BC116968 ENSMUST00000209620.1 ENSMUST00000209620.2 ENSMUST00000209620.3 Olfr512 Or10a3m Q7TRU5 Q7TRU5_MOUSE uc291uhq.1 uc291uhq.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uhq.1 uc291uhq.2 
ENSMUST00000209624.2 Gm45509 ENSMUST00000209624.2 Gm45509 (from geneSymbol) ENSMUST00000209624.1 uc291may.1 uc291may.2 uc291may.1 uc291may.2 
ENSMUST00000209629.2 Gm45629 ENSMUST00000209629.2 Gm45629 (from geneSymbol) AK083645 ENSMUST00000209629.1 uc291qau.1 uc291qau.2 uc291qau.1 uc291qau.2 
ENSMUST00000209642.3 Gm42067 ENSMUST00000209642.3 Gm42067 (from geneSymbol) ENSMUST00000209642.1 ENSMUST00000209642.2 uc289qix.1 uc289qix.2 uc289qix.3 uc289qix.1 uc289qix.2 uc289qix.3 
ENSMUST00000209644.2 Gm45415 ENSMUST00000209644.2 Gm45415 (from geneSymbol) ENSMUST00000209644.1 uc291lfa.1 uc291lfa.2 uc291lfa.1 uc291lfa.2 
ENSMUST00000209647.2 Gm45411 ENSMUST00000209647.2 Gm45411 (from geneSymbol) ENSMUST00000209647.1 uc291yzd.1 uc291yzd.2 uc291yzd.1 uc291yzd.2 
ENSMUST00000209648.2 Gm38416 ENSMUST00000209648.2 predicted gene, 38416 (from RefSeq NR_131057.1) ENSMUST00000209648.1 NR_131057 uc057ane.1 uc057ane.2 uc057ane.1 uc057ane.2 
ENSMUST00000209650.2 Gm45278 ENSMUST00000209650.2 Gm45278 (from geneSymbol) AK047118 ENSMUST00000209650.1 uc291wos.1 uc291wos.2 uc291wos.1 uc291wos.2 
ENSMUST00000209663.3 Gm39244 ENSMUST00000209663.3 predicted gene, 39244, transcript variant 3 (from RefSeq NR_166532.1) ENSMUST00000209663.1 ENSMUST00000209663.2 NR_166532 uc009nib.1 uc009nib.2 uc009nib.3 uc009nib.1 uc009nib.2 uc009nib.3 
ENSMUST00000209665.3 Gm45604 ENSMUST00000209665.3 Gm45604 (from geneSymbol) AK076845 ENSMUST00000209665.1 ENSMUST00000209665.2 uc007hha.1 uc007hha.2 uc007hha.3 uc007hha.1 uc007hha.2 uc007hha.3 
ENSMUST00000209669.2 Gm45861 ENSMUST00000209669.2 POTE ankyrin domain family, member G, transcript variant 3 (from RefSeq NM_001401513.1) A0A1B0GRY3 A0A1B0GRY3_MOUSE ENSMUST00000209669.1 Gm45861 NM_001401513 uc291zcv.1 uc291zcv.2 uc291zcv.1 uc291zcv.2 
ENSMUST00000209671.3 Gm45571 ENSMUST00000209671.3 Gm45571 (from geneSymbol) ENSMUST00000209671.1 ENSMUST00000209671.2 uc291zdg.1 uc291zdg.2 uc291zdg.3 uc291zdg.1 uc291zdg.2 uc291zdg.3 
ENSMUST00000209685.2 Gm45470 ENSMUST00000209685.2 Gm45470 (from geneSymbol) ENSMUST00000209685.1 uc057aku.1 uc057aku.2 uc057aku.3 uc057aku.1 uc057aku.2 uc057aku.3 
ENSMUST00000209690.2 Gm45785 ENSMUST00000209690.2 Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex. (from UniProt A0A1B0GT05) A0A1B0GT05 A0A1B0GT05_MOUSE AK158871 ENSMUST00000209690.1 Gm45785 uc291wwd.1 uc291wwd.2 Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex. Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L. Golgi apparatus, trans-Golgi network membrane Membrane ; Single-pass type IV membrane protein Golgi trans cisterna SNAP receptor activity cytosol protein transport integral component of Golgi membrane SNARE complex retrograde transport, endosome to Golgi membrane fusion regulation of retrograde vesicle-mediated transport, Golgi to ER uc291wwd.1 uc291wwd.2 
ENSMUST00000209697.3 4930465I24Rik ENSMUST00000209697.3 4930465I24Rik (from geneSymbol) AK019638 ENSMUST00000209697.1 ENSMUST00000209697.2 uc291yem.1 uc291yem.2 uc291yem.3 uc291yem.1 uc291yem.2 uc291yem.3 
ENSMUST00000209700.2 Gm45672 ENSMUST00000209700.2 Gm45672 (from geneSymbol) ENSMUST00000209700.1 uc291wlj.1 uc291wlj.2 uc291wlj.1 uc291wlj.2 
ENSMUST00000209713.2 Gm45416 ENSMUST00000209713.2 Gm45416 (from geneSymbol) ENSMUST00000209713.1 LF196696 uc291xfo.1 uc291xfo.2 uc291xfo.1 uc291xfo.2 
ENSMUST00000209717.2 Gm45481 ENSMUST00000209717.2 Gm45481 (from geneSymbol) AK082031 ENSMUST00000209717.1 uc291ztk.1 uc291ztk.2 uc291ztk.1 uc291ztk.2 
ENSMUST00000209731.2 B430319F04Rik ENSMUST00000209731.2 B430319F04Rik (from geneSymbol) AK046704 ENSMUST00000209731.1 uc291ull.1 uc291ull.2 uc291ull.1 uc291ull.2 
ENSMUST00000209736.2 Gm45634 ENSMUST00000209736.2 Gm45634 (from geneSymbol) ENSMUST00000209736.1 uc292aca.1 uc292aca.2 uc292aca.1 uc292aca.2 
ENSMUST00000209738.2 1700047O18Rik ENSMUST00000209738.2 1700047O18Rik (from geneSymbol) ENSMUST00000209738.1 uc291lpp.1 uc291lpp.2 uc291lpp.1 uc291lpp.2 
ENSMUST00000209743.2 Or5p69 ENSMUST00000209743.2 Potential odorant receptor. (from UniProt Q8VG07) ENSMUST00000209743.1 Mor204-10 O5P69_MOUSE Olfr494 Or5p69 Q8VG07 uc009jci.1 uc009jci.2 uc009jci.3 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jci.1 uc009jci.2 uc009jci.3 
ENSMUST00000209750.2 Hdac9 ENSMUST00000209750.2 histone deacetylase 9, transcript variant 1 (from RefSeq NM_001271386.1) A0A1B0GSQ5 A0A1B0GSQ5_MOUSE ENSMUST00000209750.1 Hdac9 NM_001271386 uc288fwv.1 uc288fwv.2 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA- COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; Evidence= Nucleus Belongs to the histone deacetylase family. HD type 2 subfamily. histone deacetylase complex histone deacetylase activity nucleus chromatin organization histone deacetylation hydrolase activity NAD-dependent histone deacetylase activity (H3-K14 specific) metal ion binding histone H3 deacetylation uc288fwv.1 uc288fwv.2 
ENSMUST00000209754.2 Gm45293 ENSMUST00000209754.2 Gm45293 (from geneSymbol) AK131762 ENSMUST00000209754.1 uc292cae.1 uc292cae.2 uc292cae.1 uc292cae.2 
ENSMUST00000209758.2 Gm45321 ENSMUST00000209758.2 Gm45321 (from geneSymbol) ENSMUST00000209758.1 uc291zvv.1 uc291zvv.2 uc291zvv.1 uc291zvv.2 
ENSMUST00000209765.2 Brd3os ENSMUST00000209765.2 bromodomain containing 3, opposite strand, transcript variant 3 (from RefSeq NM_001360792.2) A0A1B0GRB6 A0A1B0GRB6_MOUSE Brd3os D2Bwg1423e ENSMUST00000209765.1 NM_001360792 uc289uix.1 uc289uix.2 molecular_function cellular_component biological_process uc289uix.1 uc289uix.2 
ENSMUST00000209767.3 1500002F19Rik ENSMUST00000209767.3 1500002F19Rik (from geneSymbol) AK005115 ENSMUST00000209767.1 ENSMUST00000209767.2 uc291wkj.1 uc291wkj.2 uc291wkj.3 uc291wkj.1 uc291wkj.2 uc291wkj.3 
ENSMUST00000209775.3 Gm45641 ENSMUST00000209775.3 Gm45641 (from geneSymbol) ENSMUST00000209775.1 ENSMUST00000209775.2 uc292byc.1 uc292byc.2 uc292byc.3 uc292byc.1 uc292byc.2 uc292byc.3 
ENSMUST00000209778.3 Or51a8 ENSMUST00000209778.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VH12) ENSMUST00000209778.1 ENSMUST00000209778.2 Olfr570 Olfr575 Or51a8 Q8VH12 Q8VH12_MOUSE uc009iss.1 uc009iss.2 uc009iss.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009iss.1 uc009iss.2 uc009iss.3 
ENSMUST00000209781.2 A230085B16Rik ENSMUST00000209781.2 A230085B16Rik (from geneSymbol) AK039012 ENSMUST00000209781.1 uc291zyc.1 uc291zyc.2 uc291zyc.1 uc291zyc.2 
ENSMUST00000209793.2 Gm32050 ENSMUST00000209793.2 Gm32050 (from geneSymbol) ENSMUST00000209793.1 uc291zam.1 uc291zam.2 uc291zam.1 uc291zam.2 
ENSMUST00000209804.2 Gm45872 ENSMUST00000209804.2 Gm45872 (from geneSymbol) AK050936 ENSMUST00000209804.1 uc292bhj.1 uc292bhj.2 uc292bhj.1 uc292bhj.2 
ENSMUST00000209808.3 Gm45669 ENSMUST00000209808.3 Gm45669 (from geneSymbol) AK021299 ENSMUST00000209808.1 ENSMUST00000209808.2 uc291poe.1 uc291poe.2 uc291poe.3 uc291poe.1 uc291poe.2 uc291poe.3 
ENSMUST00000209813.2 Gm39231 ENSMUST00000209813.2 Gm39231 (from geneSymbol) ENSMUST00000209813.1 uc292cnh.1 uc292cnh.2 uc292cnh.1 uc292cnh.2 
ENSMUST00000209814.2 G630064G18Rik ENSMUST00000209814.2 RIKEN cDNA G630064G18 gene (from RefSeq NR_126063.1) ENSMUST00000209814.1 NR_126063 uc009llw.1 uc009llw.2 uc009llw.1 uc009llw.2 
ENSMUST00000209816.2 Gm45397 ENSMUST00000209816.2 Gm45397 (from geneSymbol) BC042867 ENSMUST00000209816.1 uc291wpd.1 uc291wpd.2 uc291wpd.1 uc291wpd.2 
ENSMUST00000209823.2 Gm42031 ENSMUST00000209823.2 predicted gene, 42031 (from RefSeq NR_168954.1) ENSMUST00000209823.1 NR_168954 uc292bsl.1 uc292bsl.2 uc292bsl.1 uc292bsl.2 
ENSMUST00000209826.2 Gm45440 ENSMUST00000209826.2 Gm45440 (from geneSymbol) ENSMUST00000209826.1 uc291wod.1 uc291wod.2 uc291wod.1 uc291wod.2 
ENSMUST00000209836.4 Gm45606 ENSMUST00000209836.4 Gm45606 (from geneSymbol) ENSMUST00000209836.1 ENSMUST00000209836.2 ENSMUST00000209836.3 LF198679 uc288afh.1 uc288afh.2 uc288afh.3 uc288afh.4 uc288afh.1 uc288afh.2 uc288afh.3 uc288afh.4 
ENSMUST00000209837.2 Gm45609 ENSMUST00000209837.2 Gm45609 (from geneSymbol) ENSMUST00000209837.1 uc290bqd.1 uc290bqd.2 uc290bqd.1 uc290bqd.2 
ENSMUST00000209844.2 Il18bp ENSMUST00000209844.2 Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response (By similarity). (from UniProt Q9Z0M9) AF122907 ENSMUST00000209844.1 I18BP_MOUSE Igifbp Q4FJR8 Q4FK87 Q9CV30 Q9QUH2 Q9Z0M9 Q9Z0N0 uc009iqd.1 uc009iqd.2 uc009iqd.3 Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response (By similarity). Secreted Sequence=AAD17193.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=AAD17194.1; Type=Erroneous initiation; Evidence=; extracellular region extracellular space response to lipopolysaccharide interleukin-18 binding T-helper 1 type immune response cellular response to hydrogen peroxide cellular response to tumor necrosis factor uc009iqd.1 uc009iqd.2 uc009iqd.3 
ENSMUST00000209845.2 Gm45483 ENSMUST00000209845.2 Gm45483 (from geneSymbol) AK148624 ENSMUST00000209845.1 uc292adl.1 uc292adl.2 uc292adl.1 uc292adl.2 
ENSMUST00000209846.2 Hrh2 ENSMUST00000209846.2 histamine receptor H2, transcript variant 4 (from RefSeq NM_001413010.1) A0A1B0GSX9 A0A1B0GSX9_MOUSE ENSMUST00000209846.1 Hrh2 NM_001413010 uc288mwz.1 uc288mwz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. gastric acid secretion G-protein coupled receptor activity histamine receptor activity signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane positive regulation of vasoconstriction uc288mwz.1 uc288mwz.2 
ENSMUST00000209848.3 1700008N11Rik ENSMUST00000209848.3 1700008N11Rik (from geneSymbol) AK005782 ENSMUST00000209848.1 ENSMUST00000209848.2 uc291zdc.1 uc291zdc.2 uc291zdc.3 uc291zdc.1 uc291zdc.2 uc291zdc.3 
ENSMUST00000209850.3 4930483O08Rik ENSMUST00000209850.3 RIKEN cDNA 4930483O08 gene (from RefSeq NR_046279.1) ENSMUST00000209850.1 ENSMUST00000209850.2 NR_046279 uc029wpa.1 uc029wpa.2 uc029wpa.3 uc029wpa.1 uc029wpa.2 uc029wpa.3 
ENSMUST00000209854.2 Gm45528 ENSMUST00000209854.2 Gm45528 (from geneSymbol) ENSMUST00000209854.1 uc291yuh.1 uc291yuh.2 uc291yuh.1 uc291yuh.2 
ENSMUST00000209859.2 Tmem241 ENSMUST00000209859.2 transmembrane protein 241, transcript variant 1 (from RefSeq NM_001289666.1) ENSMUST00000209859.1 NM_001289666 Q3UME2 Q8BQ16 Q8CAM4 Q8CAM9 Q8CD42 TM241_MOUSE uc008ebv.1 uc008ebv.2 uc008ebv.3 uc008ebv.4 uc008ebv.5 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3UME2-1; Sequence=Displayed; Name=2; IsoId=Q3UME2-2; Sequence=VSP_028714; Name=3; IsoId=Q3UME2-3; Sequence=VSP_028710, VSP_028713; Name=4; IsoId=Q3UME2-4; Sequence=VSP_028709, VSP_028711, VSP_028712; Belongs to the TMEM241 family. Sequence=BAC30011.1; Type=Frameshift; Evidence=; nucleotide-sugar transmembrane transporter activity GDP-fucose transmembrane transporter activity Golgi apparatus antiporter activity GDP-fucose transport nucleobase-containing compound transport membrane integral component of membrane transmembrane transporter activity transmembrane transport carbohydrate derivative transport uc008ebv.1 uc008ebv.2 uc008ebv.3 uc008ebv.4 uc008ebv.5 
ENSMUST00000209862.2 Ccdc200 ENSMUST00000209862.2 coiled coil domain containing 200, transcript variant 1 (from RefSeq NM_001372545.1) A0A1B0GSX1 A0A1B0GSX1_MOUSE Ccdc200 ENSMUST00000209862.1 Gm11634 NM_001372545 uc288ckz.1 uc288ckz.2 uc288ckz.1 uc288ckz.2 
ENSMUST00000209866.4 Or6z7 ENSMUST00000209866.4 Odorant receptor. (from UniProt Q60889) ENSMUST00000209866.1 ENSMUST00000209866.2 ENSMUST00000209866.3 Mor103-8 OR6Z7_MOUSE Olfr5 Or6z7 Q3MI75 Q60889 Q8VGH4 uc291lcd.1 uc291lcd.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291lcd.1 uc291lcd.2 
ENSMUST00000209871.3 Or13a23-ps1 ENSMUST00000209871.3 Or13a23-ps1 (from geneSymbol) ENSMUST00000209871.1 ENSMUST00000209871.2 uc291wve.1 uc291wve.2 uc291wve.1 uc291wve.2 
ENSMUST00000209874.3 Gm45447 ENSMUST00000209874.3 Gm45447 (from geneSymbol) ENSMUST00000209874.1 ENSMUST00000209874.2 uc290cgj.1 uc290cgj.2 uc290cgj.3 uc290cgj.1 uc290cgj.2 uc290cgj.3 
ENSMUST00000209879.3 Or56a5 ENSMUST00000209879.3 Membrane ; Multi- pass membrane protein (from UniProt Q7TRN9) ENSMUST00000209879.1 ENSMUST00000209879.2 Olfr683 Or56a5 Q7TRN9 Q7TRN9_MOUSE uc291twu.1 uc291twu.2 Membrane ; Multi- pass membrane protein dopamine neurotransmitter receptor activity, coupled via Gi/Go synaptic transmission, dopaminergic G-protein coupled receptor activity adrenergic receptor activity olfactory receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway sensory perception of smell response to toxic substance regulation of dopamine secretion membrane integral component of membrane synaptic vesicle membrane dopamine binding response to drug regulation of potassium ion transport behavioral response to cocaine behavioral response to ethanol response to stimulus detection of chemical stimulus involved in sensory perception of smell negative regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway negative regulation of synaptic transmission, glutamatergic phospholipase C-activating dopamine receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway negative regulation of voltage-gated calcium channel activity uc291twu.1 uc291twu.2 
ENSMUST00000209882.2 Gm45459 ENSMUST00000209882.2 Gm45459 (from geneSymbol) ENSMUST00000209882.1 uc292aen.1 uc292aen.2 uc292aen.1 uc292aen.2 
ENSMUST00000209885.2 Tfdp1 ENSMUST00000209885.2 transcription factor Dp 1, transcript variant 33 (from RefSeq NR_182219.1) ENSMUST00000209885.1 NR_182219 Q3V3X3 Q3V3X3_MOUSE Tfdp1 uc009kxp.1 uc009kxp.2 uc009kxp.3 Nucleus Belongs to the E2F/DP family. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor complex cytosol regulation of transcription, DNA-templated transcription factor binding protein domain specific binding positive regulation of transcription from RNA polymerase II promoter regulation of cell cycle RNA polymerase II transcription factor complex uc009kxp.1 uc009kxp.2 uc009kxp.3 
ENSMUST00000209890.2 Krtap5-26 ENSMUST00000209890.2 predicted gene 45618 (from RefSeq NM_001347558.1) A0A1B0GSA0 A0A1B0GSA0_MOUSE ENSMUST00000209890.1 Gm45618 NM_001347558 uc057lvx.1 uc057lvx.2 keratin filament uc057lvx.1 uc057lvx.2 
ENSMUST00000209893.2 Gm45297 ENSMUST00000209893.2 Gm45297 (from geneSymbol) ENSMUST00000209893.1 uc292cnp.1 uc292cnp.2 uc292cnp.1 uc292cnp.2 
ENSMUST00000209897.2 AU023762 ENSMUST00000209897.2 expressed sequence AU023762 (from RefSeq NR_040760.1) ENSMUST00000209897.1 NR_040760 uc009rwk.1 uc009rwk.2 uc009rwk.1 uc009rwk.2 
ENSMUST00000209900.2 Gm45458 ENSMUST00000209900.2 Gm45458 (from geneSymbol) AK039659 ENSMUST00000209900.1 uc291zoz.1 uc291zoz.2 uc291zoz.1 uc291zoz.2 
ENSMUST00000209909.2 Grk1 ENSMUST00000209909.2 Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (from UniProt G3X905) BC096611 ENSMUST00000209909.1 G3X905 G3X905_MOUSE Grk1 uc291yjp.1 uc291yjp.2 Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity G-protein coupled receptor kinase activity ATP binding protein phosphorylation signal transduction visual perception kinase activity phosphorylation transferase activity regulation of rhodopsin mediated signaling pathway protein autophosphorylation rhodopsin kinase activity uc291yjp.1 uc291yjp.2 
ENSMUST00000209913.2 Fbxo25 ENSMUST00000209913.2 F-box protein 25, transcript variant 3 (from RefSeq NM_001359061.1) A0A1B0GRC8 A0A1B0GRC8_MOUSE ENSMUST00000209913.1 Fbxo25 NM_001359061 uc009kyt.1 uc009kyt.2 uc009kyt.3 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT). Protein modification; protein ubiquitination. Nucleus nucleus uc009kyt.1 uc009kyt.2 uc009kyt.3 
ENSMUST00000209914.2 Or56b2j ENSMUST00000209914.2 olfactory receptor family 56 subfamily B member 2J (from RefSeq NM_001011757.1) A0A1B0GSI9 A0A1B0GSI9_MOUSE ENSMUST00000209914.1 NM_001011757 Or56b2j uc291tuy.1 uc291tuy.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tuy.1 uc291tuy.2 
ENSMUST00000209917.2 Gm45262 ENSMUST00000209917.2 Gm45262 (from geneSymbol) AK086396 ENSMUST00000209917.1 uc291zyb.1 uc291zyb.2 uc291zyb.1 uc291zyb.2 
ENSMUST00000209918.2 Gm45496 ENSMUST00000209918.2 Gm45496 (from geneSymbol) AK047535 ENSMUST00000209918.1 uc292bww.1 uc292bww.2 uc292bww.1 uc292bww.2 
ENSMUST00000209929.2 Gm45553 ENSMUST00000209929.2 Gm45553 (from geneSymbol) AB350463 ENSMUST00000209929.1 uc291zxk.1 uc291zxk.2 uc291zxk.1 uc291zxk.2 
ENSMUST00000209931.2 Gm45457 ENSMUST00000209931.2 Gm45457 (from geneSymbol) AK084776 ENSMUST00000209931.1 uc291zpy.1 uc291zpy.2 uc291zpy.1 uc291zpy.2 
ENSMUST00000209934.2 Gm35392 ENSMUST00000209934.2 Gm35392 (from geneSymbol) AK047874 ENSMUST00000209934.1 uc291ymm.1 uc291ymm.2 uc291ymm.1 uc291ymm.2 
ENSMUST00000209936.2 Gm31479 ENSMUST00000209936.2 Gm31479 (from geneSymbol) ENSMUST00000209936.1 uc291pvv.1 uc291pvv.2 uc291pvv.1 uc291pvv.2 
ENSMUST00000209943.2 Gm45255 ENSMUST00000209943.2 Gm45255 (from geneSymbol) AK043058 ENSMUST00000209943.1 uc291zru.1 uc291zru.2 uc291zru.1 uc291zru.2 
ENSMUST00000209951.4 Gm36445 ENSMUST00000209951.4 Gm36445 (from geneSymbol) ENSMUST00000209951.1 ENSMUST00000209951.2 ENSMUST00000209951.3 uc288nxy.1 uc288nxy.2 uc288nxy.3 uc288nxy.4 uc288nxy.1 uc288nxy.2 uc288nxy.3 uc288nxy.4 
ENSMUST00000209955.2 Gm45399 ENSMUST00000209955.2 Gm45399 (from geneSymbol) ENSMUST00000209955.1 LF204890 uc291tml.1 uc291tml.2 uc291tml.1 uc291tml.2 
ENSMUST00000209956.2 Gm36431 ENSMUST00000209956.2 Gm36431 (from geneSymbol) ENSMUST00000209956.1 uc291woa.1 uc291woa.2 uc291woa.1 uc291woa.2 
ENSMUST00000209960.4 Gm42303 ENSMUST00000209960.4 predicted gene, 42303 (from RefSeq NR_168523.1) ENSMUST00000209960.1 ENSMUST00000209960.2 ENSMUST00000209960.3 NR_168523 uc290njl.1 uc290njl.2 uc290njl.3 uc290njl.4 uc290njl.1 uc290njl.2 uc290njl.3 uc290njl.4 
ENSMUST00000209963.2 Aldh16a1 ENSMUST00000209963.2 aldehyde dehydrogenase 16 family, member A1 (from RefSeq NM_145954.2) A0A1B0GSU0 A0A1B0GSU0_MOUSE Aldh16a1 ENSMUST00000209963.1 NM_145954 uc009gtr.1 uc009gtr.2 uc009gtr.3 Interacts with SPG21. Belongs to the aldehyde dehydrogenase family. oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor oxidation-reduction process uc009gtr.1 uc009gtr.2 uc009gtr.3 
ENSMUST00000209971.2 Gm40193 ENSMUST00000209971.2 predicted gene, 40193, transcript variant 1 (from RefSeq NM_001384255.1) A0A1B0GT39 A0A1B0GT39_MOUSE ENSMUST00000209971.1 Gm40193 NM_001384255 uc287zqs.1 uc287zqs.2 uc287zqs.1 uc287zqs.2 
ENSMUST00000209973.2 Gm45517 ENSMUST00000209973.2 Gm45517 (from geneSymbol) ENSMUST00000209973.1 uc292aew.1 uc292aew.2 uc292aew.1 uc292aew.2 
ENSMUST00000209975.2 Gm45677 ENSMUST00000209975.2 Gm45677 (from geneSymbol) ENSMUST00000209975.1 uc291ymr.1 uc291ymr.2 uc291ymr.1 uc291ymr.2 
ENSMUST00000209977.2 B020031H02Rik ENSMUST00000209977.2 B020031H02Rik (from geneSymbol) AK139872 ENSMUST00000209977.1 uc291yfk.1 uc291yfk.2 uc291yfk.1 uc291yfk.2 
ENSMUST00000209979.2 Ptpre ENSMUST00000209979.2 protein tyrosine phosphatase receptor type E, transcript variant 5 (from RefSeq NM_001316681.1) ENSMUST00000209979.1 NM_001316681 P49446 PTPRE_MOUSE Ptpe Q3U369 Q60986 Q61042 Q62134 Q62444 Q64496 uc009kek.1 uc009kek.2 uc009kek.3 uc009kek.4 [Isoform 1]: Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver (By similarity). Plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function. [Isoform 2]: Acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake. Isoform 1 and isoform 2 act as a negative regulator of FceRI- mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence= [Isoform 1]: Inhibited by alendronate (ALN), orthovanadate, and phenylarsine oxide (PAO). Kinetic parameters: KM=70 uM for fluorescein diphosphate (isoform 1) ; Vmax=6 umol/min/mg enzyme for fluorescein diphosphate (isoform 1) ; Monomer (By similarity). Isoform 2: Homodimer. Can form oligomers. Dimerization is increased by oxidative stress and decreased by EGFR. Isoform 2 interacts with GRB2 (By similarity). [Isoform 1]: Cell membrane; Single-pass type I membrane protein. [Isoform 2]: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin can induce translocation to the membrane. [Isoform 3]: Cytoplasm. Event=Alternative promoter usage, Alternative initiation; Named isoforms=3; Name=1; Synonyms=PTPeM, RPTPe, tm-PTPe; IsoId=P49446-1; Sequence=Displayed; Name=2; Synonyms=PTPeC, cyt-PTPe; IsoId=P49446-2; Sequence=VSP_038492; Name=3; Synonyms=p67; IsoId=P49446-3; Sequence=VSP_038491; Isoform 2 is expressed in the spleen and thymus (at protein level). Detected in fibroblasts, myeloid cells, macrophages, and T-cells but not in B-cell lines. Isoform 1 and isoform 2 are expressed predominantly in the brain, testes, and lungs, with lower levels present in lymph nodes, thymus, spleen, heart and mammary glands. Isoform 1 is expressed in osteoclasts and not in osteoblasts and its expression is related to osteoclast differentiation. It is also expressed in the erythrocytes. Isoform 2 is strongly expressed in skeletal muscle and L6 skeletal muscle cell line. [Isoform 2]: Induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and its induction is dependent upon PKC activity. The tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the D2 domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme activity. A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3. [Isoform 1]: Phosphorylated on tyrosine residues by tyrosine kinase Neu. [Isoform 2]: Phosphorylated on tyrosine residues by tyrosine kinase Neu. [Isoform 1]: Glycosylated. Mice show greater insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1) in the skeletal muscle. Antigen- and IgE-mediated passive systemic anaphylactic reactions are enhanced. Erythrocytes exhibit abnormal morphology, increased Ca(2+)-activated-K(+) channel activity and marked perturbation of the erythrocyte membrane tyrosine phosphoproteome. [Isoform 1]: Produced by alternative promoter usage. [Isoform 2]: Produced by alternative promoter usage. [Isoform 3]: Produced by alternative initiation at Met- 85 of isoform 1. Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleus cytoplasm plasma membrane protein dephosphorylation transmembrane receptor protein tyrosine phosphatase signaling pathway membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity regulation of mast cell activation peptidyl-tyrosine dephosphorylation protein homodimerization activity negative regulation of insulin receptor signaling pathway uc009kek.1 uc009kek.2 uc009kek.3 uc009kek.4 
ENSMUST00000210004.2 Gm45557 ENSMUST00000210004.2 Gm45557 (from geneSymbol) ENSMUST00000210004.1 uc291twh.1 uc291twh.2 uc291twh.1 uc291twh.2 
ENSMUST00000210005.2 Isyna1 ENSMUST00000210005.2 Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). (from UniProt Q9JHU9) AF288525 ENSMUST00000210005.1 INO1_MOUSE Ino1 Q9JHU9 uc292aqd.1 uc292aqd.2 Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate; Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548; EC=5.5.1.4; Evidence=; Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence=; Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2. Cytoplasm In testis, it is expressed in Sertoli cells. Highly expressed in 2 types of germ cells, pachytene spermatocytes and round spermatids. Belongs to the myo-inositol 1-phosphate synthase family. inositol-3-phosphate synthase activity cytoplasm inositol biosynthetic process lipid metabolic process phospholipid biosynthetic process isomerase activity uc292aqd.1 uc292aqd.2 
ENSMUST00000210010.2 Gm45336 ENSMUST00000210010.2 Gm45336 (from geneSymbol) ENSMUST00000210010.1 uc292cbd.1 uc292cbd.2 uc292cbd.1 uc292cbd.2 
ENSMUST00000210011.2 Gm2516 ENSMUST00000210011.2 predicted gene 2516 (from RefSeq NR_046067.1) ENSMUST00000210011.1 NR_046067 uc029wsx.1 uc029wsx.2 uc029wsx.3 uc029wsx.1 uc029wsx.2 uc029wsx.3 
ENSMUST00000210028.2 Gm45555 ENSMUST00000210028.2 Gm45555 (from geneSymbol) AK081157 ENSMUST00000210028.1 uc291yso.1 uc291yso.2 uc291yso.1 uc291yso.2 
ENSMUST00000210032.2 Lingo1 ENSMUST00000210032.2 leucine rich repeat and Ig domain containing 1, transcript variant 2 (from RefSeq NM_181074.5) ENSMUST00000210032.1 LIGO1_MOUSE Lern1 Lrrn6a NM_181074 Q3TQJ4 Q6VVF9 Q7TT38 Q9D1T0 uc033jkt.1 uc033jkt.2 uc033jkt.3 Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. Homotetramer. Forms a ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19 (By similarity). Interacts with NGRF and MYT1L (PubMed:18186492). Interacts with RTN4R (PubMed:18186492, PubMed:22923615). Q9D1T0; P12023: App; NbExp=2; IntAct=EBI-2012981, EBI-78814; Cell membrane ; Single-pass type I membrane protein Highly specific expression in the central nervous system. Predominant expression in neocortex, amygdala, hippocampus, thalamus and entorhinal cortex, with lower levels in cerebellum and basal nuclei. Expressed broadly at high levels in the whole embryo and becomes progressively restricted to the central nervous system by 14.5 dpc. Extensively expressed across the central nervous system through late embryogenesis and during postnatal development, with a peak of expression around the first week after birth. Up-regulated in brain from MPTP-intoxicated mice, a model for Parkinson disease. The intracellular domain of LINGO1 interacts with MYT1L. N-glycosylated. Contains predominantly high-mannose glycans (By similarity). In mice lacking Lingo1 and MPTP-intoxicated, a model for Parkinson disease, the dopaminergic neurons survival is increased and behavioral abnormalities reduced. epidermal growth factor receptor binding protein binding extracellular space plasma membrane membrane integral component of membrane central nervous system neuron development extracellular matrix neuron projection development protein kinase B signaling negative regulation of oligodendrocyte differentiation uc033jkt.1 uc033jkt.2 uc033jkt.3 
ENSMUST00000210035.2 Gm38948 ENSMUST00000210035.2 Gm38948 (from geneSymbol) ENSMUST00000210035.1 uc291lzb.1 uc291lzb.2 uc291lzb.1 uc291lzb.2 
ENSMUST00000210042.2 Gm45258 ENSMUST00000210042.2 Gm45258 (from geneSymbol) AK043207 ENSMUST00000210042.1 uc292coj.1 uc292coj.2 uc292coj.1 uc292coj.2 
ENSMUST00000210045.2 Gm39204 ENSMUST00000210045.2 Gm39204 (from geneSymbol) ENSMUST00000210045.1 uc292bfr.1 uc292bfr.2 uc292bfr.1 uc292bfr.2 
ENSMUST00000210052.3 Gm35315 ENSMUST00000210052.3 May be involved in transcriptional regulation. (from UniProt A0A1B0GRI2) A0A1B0GRI2 A0A1B0GRI2_MOUSE ENSMUST00000210052.1 ENSMUST00000210052.2 Gm35315 uc290yct.1 uc290yct.2 uc290yct.3 May be involved in transcriptional regulation. transcription regulatory region sequence-specific DNA binding nucleic acid binding nucleus regulation of transcription, DNA-templated metal ion binding uc290yct.1 uc290yct.2 uc290yct.3 
ENSMUST00000210054.2 Gm45662 ENSMUST00000210054.2 Gm45662 (from geneSymbol) AK031406 ENSMUST00000210054.1 uc292bzq.1 uc292bzq.2 uc292bzq.1 uc292bzq.2 
ENSMUST00000210059.2 Gm45510 ENSMUST00000210059.2 Gm45510 (from geneSymbol) ENSMUST00000210059.1 uc291maz.1 uc291maz.2 uc291maz.1 uc291maz.2 
ENSMUST00000210064.4 Or52b4i ENSMUST00000210064.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1B0GSG0) A0A1B0GSG0 A0A1B0GSG0_MOUSE ENSMUST00000210064.1 ENSMUST00000210064.2 ENSMUST00000210064.3 Olfr548 Or52b4i uc291tmu.1 uc291tmu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tmu.1 uc291tmu.2 
ENSMUST00000210076.3 Gm45548 ENSMUST00000210076.3 Gm45548 (from geneSymbol) ENSMUST00000210076.1 ENSMUST00000210076.2 uc291tgr.1 uc291tgr.2 uc291tgr.3 uc291tgr.1 uc291tgr.2 uc291tgr.3 
ENSMUST00000210090.2 Gm45264 ENSMUST00000210090.2 Gm45264 (from geneSymbol) ENSMUST00000210090.1 uc291zya.1 uc291zya.2 uc291zya.1 uc291zya.2 
ENSMUST00000210105.2 Gm35021 ENSMUST00000210105.2 Gm35021 (from geneSymbol) ENSMUST00000210105.1 uc291ziq.1 uc291ziq.2 uc291ziq.1 uc291ziq.2 
ENSMUST00000210109.2 Gm45520 ENSMUST00000210109.2 Gm45520 (from geneSymbol) AK039423 ENSMUST00000210109.1 uc291ylb.1 uc291ylb.2 uc291ylb.1 uc291ylb.2 
ENSMUST00000210111.2 Gm45266 ENSMUST00000210111.2 Gm45266 (from geneSymbol) AK042782 ENSMUST00000210111.1 uc291zck.1 uc291zck.2 uc291zck.1 uc291zck.2 
ENSMUST00000210130.2 Gm45627 ENSMUST00000210130.2 Gm45627 (from geneSymbol) ENSMUST00000210130.1 uc291zhk.1 uc291zhk.2 uc291zhk.1 uc291zhk.2 
ENSMUST00000210131.2 Gm45883 ENSMUST00000210131.2 Gm45883 (from geneSymbol) BC034117 ENSMUST00000210131.1 uc288bin.1 uc288bin.2 uc288bin.1 uc288bin.2 
ENSMUST00000210136.2 Triml2 ENSMUST00000210136.2 tripartite motif family-like 2, transcript variant 2 (from RefSeq NM_001160412.2) E9PW10 E9PW10_MOUSE ENSMUST00000210136.1 NM_001160412 Triml2 uc012gcu.1 uc012gcu.2 uc012gcu.3 molecular_function cellular_component response to organic substance response to retinoic acid uc012gcu.1 uc012gcu.2 uc012gcu.3 
ENSMUST00000210139.2 Pih1d1 ENSMUST00000210139.2 PIH1 domain containing 1, transcript variant 2 (from RefSeq NM_001278207.1) ENSMUST00000210139.1 NM_001278207 Nop17 PIHD1_MOUSE Q6NV90 Q9CQJ2 uc009gtv.1 uc009gtv.2 uc009gtv.3 Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity). Component of the R2TP complex composed at least of RUVBL1, RUVBL2, RPAP3 and PIHD1 (By similarity). Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92 (By similarity). Interacts with phosphorylated TELO2 (PubMed:24794838). Mediates interaction of TELO2 with the R2TP complex (By similarity). Interacts with phosphorylated ECD, EFTUD2/SNRP116, RPB1 and UBR5 and with RPB1 in a phosphorylation-independent manner (By similarity). Interacts with the core C/D box snoRNP particle components NOP58 and FBL and with RUVBL1/TIP49 (By similarity). Interacts with RPAP3 and DNAAF10 (By similarity). Interacts with histone H4 and with SWI/SNF complex member SMARCB1/SNF5 (By similarity). Interacts with the mTORC1 complex member RPTOR (By similarity). Interacts with isoform 1 of MSL1 (PubMed:17335777). Q9CQJ2; Q9DC40: Telo2; NbExp=3; IntAct=EBI-11658528, EBI-1571482; Nucleus The N-terminal region is required for binding to phosphorylated substrates while the C-terminal region binds to the other R2TP complex components. Belongs to the PIH1 family. box C/D snoRNP assembly RNA polymerase I CORE element sequence-specific DNA binding RNA polymerase I transcriptional preinitiation complex assembly protein binding nucleus nucleolus cytoplasm chromatin remodeling rRNA processing protein kinase binding epithelial cell differentiation positive regulation of protein complex assembly histone binding snoRNA localization ATPase binding phosphoprotein binding regulation of histone H3-K4 methylation pre-snoRNP complex establishment of protein localization to chromatin positive regulation of protein serine/threonine kinase activity positive regulation of histone H4 acetylation R2TP complex negative regulation of histone H3-K9 dimethylation negative regulation of histone H3-K9 trimethylation positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter positive regulation of glucose mediated signaling pathway positive regulation of TORC1 signaling positive regulation of histone H3-K9 acetylation negative regulation of histone H4-K16 acetylation negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway uc009gtv.1 uc009gtv.2 uc009gtv.3 
ENSMUST00000210143.2 Gm45431 ENSMUST00000210143.2 Gm45431 (from geneSymbol) ENSMUST00000210143.1 uc292bhb.1 uc292bhb.2 uc292bhb.1 uc292bhb.2 
ENSMUST00000210156.2 Gm34066 ENSMUST00000210156.2 predicted gene, 34066 (from RefSeq NM_001378419.1) A0A5F8MPB3 A0A5F8MPB3_MOUSE ENSMUST00000210156.1 Gm34066 NM_001378419 uc287idn.1 uc287idn.2 uc287idn.1 uc287idn.2 
ENSMUST00000210161.2 Gm45406 ENSMUST00000210161.2 Gm45406 (from geneSymbol) AK041817 ENSMUST00000210161.1 uc292bea.1 uc292bea.2 uc292bea.1 uc292bea.2 
ENSMUST00000210173.3 Or5p6 ENSMUST00000210173.3 olfactory receptor family 5 subfamily P member 6 (from RefSeq NM_146734.2) ENSMUST00000210173.1 ENSMUST00000210173.2 Mor204-13 NM_146734 OR5P6_MOUSE Olfr478 Or5p6 Q8VG04 uc291ufx.1 uc291ufx.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DR065530.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ufx.1 uc291ufx.2 
ENSMUST00000210178.3 Gm39158 ENSMUST00000210178.3 Gm39158 (from geneSymbol) ENSMUST00000210178.1 ENSMUST00000210178.2 uc291zgv.1 uc291zgv.2 uc291zgv.3 uc291zgv.1 uc291zgv.2 uc291zgv.3 
ENSMUST00000210185.2 Gm45751 ENSMUST00000210185.2 Gm45751 (from geneSymbol) AK015074 ENSMUST00000210185.1 uc291zda.1 uc291zda.2 uc291zda.1 uc291zda.2 
ENSMUST00000210196.2 Gm45363 ENSMUST00000210196.2 Gm45363 (from geneSymbol) AK134706 ENSMUST00000210196.1 uc292byp.1 uc292byp.2 uc292byp.1 uc292byp.2 
ENSMUST00000210202.2 Nanos3 ENSMUST00000210202.2 nanos C2HC-type zinc finger 3, transcript variant 2 (from RefSeq NM_001357361.1) ENSMUST00000210202.1 NM_001357361 Nanos3 Q0VDU5 Q0VDU5_MOUSE uc009mmf.1 uc009mmf.2 uc009mmf.3 Belongs to the nanos family. RNA binding regulation of translation zinc ion binding uc009mmf.1 uc009mmf.2 uc009mmf.3 
ENSMUST00000210205.2 Gm31323 ENSMUST00000210205.2 Gm31323 (from geneSymbol) ENSMUST00000210205.1 uc289gjp.1 uc289gjp.2 uc289gjp.1 uc289gjp.2 
ENSMUST00000210206.2 Gm45577 ENSMUST00000210206.2 Gm45577 (from geneSymbol) ENSMUST00000210206.1 uc291zvp.1 uc291zvp.2 uc291zvp.1 uc291zvp.2 
ENSMUST00000210214.2 ENSMUSG00000121858 ENSMUST00000210214.2 ENSMUSG00000121858 (from geneSymbol) ENSMUST00000210214.1 uc291wfq.1 uc291wfq.2 uc291wfq.1 uc291wfq.2 
ENSMUST00000210217.2 Gm45412 ENSMUST00000210217.2 Gm45412 (from geneSymbol) ENSMUST00000210217.1 LF196847 uc291ytj.1 uc291ytj.2 uc291ytj.1 uc291ytj.2 
ENSMUST00000210219.2 Cr2 ENSMUST00000210219.2 complement receptor 2, transcript variant 1 (from RefSeq NM_001368765.1) A0A1B0GS59 A0A1B0GS59_MOUSE Cr2 ENSMUST00000210219.1 NM_001368765 uc287pfd.1 uc287pfd.2 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc287pfd.1 uc287pfd.2 
ENSMUST00000210223.3 Gm40493 ENSMUST00000210223.3 Gm40493 (from geneSymbol) ENSMUST00000210223.1 ENSMUST00000210223.2 uc291zkf.1 uc291zkf.2 uc291zkf.3 uc291zkf.1 uc291zkf.2 uc291zkf.3 
ENSMUST00000210229.2 Gm35625 ENSMUST00000210229.2 Gm35625 (from geneSymbol) AK034435 ENSMUST00000210229.1 uc291wlm.1 uc291wlm.2 uc291wlm.1 uc291wlm.2 
ENSMUST00000210241.4 Or13a28 ENSMUST00000210241.4 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGM2) ENSMUST00000210241.1 ENSMUST00000210241.2 ENSMUST00000210241.3 F7CKX1 Olfr45 Olfr61 Or13a28 Q8VGM2 Q8VGM2_MOUSE uc291wvk.1 uc291wvk.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291wvk.1 uc291wvk.2 
ENSMUST00000210243.2 Gm45630 ENSMUST00000210243.2 Gm45630 (from geneSymbol) AK037319 ENSMUST00000210243.1 uc291xhd.1 uc291xhd.2 uc291xhd.1 uc291xhd.2 
ENSMUST00000210244.2 Gm45684 ENSMUST00000210244.2 Gm45684 (from geneSymbol) AK046587 ENSMUST00000210244.1 uc291ubq.1 uc291ubq.2 uc291ubq.1 uc291ubq.2 
ENSMUST00000210247.2 Gm45868 ENSMUST00000210247.2 Gm45868 (from geneSymbol) ENSMUST00000210247.1 uc291ueh.1 uc291ueh.2 uc291ueh.1 uc291ueh.2 
ENSMUST00000210253.2 Gm5608 ENSMUST00000210253.2 Gm5608 (from geneSymbol) AK089977 ENSMUST00000210253.1 uc291yju.1 uc291yju.2 uc291yju.1 uc291yju.2 
ENSMUST00000210254.2 Spef1l ENSMUST00000210254.2 sperm flagellar 1 like, transcript variant 2 (from RefSeq NM_001347613.2) 6430531B16Rik A0A1B0GR09 A0A1B0GR09_MOUSE ENSMUST00000210254.1 NM_001347613 Spef1l uc012fwa.1 uc012fwa.2 uc012fwa.3 axoneme microtubule binding regulation of cytoskeleton organization uc012fwa.1 uc012fwa.2 uc012fwa.3 
ENSMUST00000210255.2 Gm45644 ENSMUST00000210255.2 Gm45644 (from geneSymbol) ENSMUST00000210255.1 uc292abn.1 uc292abn.2 uc292abn.1 uc292abn.2 
ENSMUST00000210258.3 Gm39149 ENSMUST00000210258.3 Gm39149 (from geneSymbol) ENSMUST00000210258.1 ENSMUST00000210258.2 uc291zal.1 uc291zal.2 uc291zal.3 uc291zal.1 uc291zal.2 uc291zal.3 
ENSMUST00000210263.3 2310008N11Rik ENSMUST00000210263.3 2310008N11Rik (from geneSymbol) ENSMUST00000210263.1 ENSMUST00000210263.2 uc291zau.1 uc291zau.2 uc291zau.3 uc291zau.1 uc291zau.2 uc291zau.3 
ENSMUST00000210265.2 Gm45605 ENSMUST00000210265.2 Gm45605 (from geneSymbol) ENSMUST00000210265.1 uc287yte.1 uc287yte.2 uc287yte.1 uc287yte.2 
ENSMUST00000210268.2 5430421F17Rik ENSMUST00000210268.2 RIKEN cDNA 5430421F17 gene (from RefSeq NR_040352.1) ENSMUST00000210268.1 NR_040352 uc009lfw.1 uc009lfw.2 uc009lfw.1 uc009lfw.2 
ENSMUST00000210274.2 Glb1l3 ENSMUST00000210274.2 galactosidase, beta 1 like 3 (from RefSeq NM_001113323.1) A0A1B0GSK9 A0A1B0GSK9_MOUSE ENSMUST00000210274.1 Glb1l3 NM_001113323 uc009opw.1 uc009opw.2 uc009opw.3 uc009opw.4 Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.; EC=3.2.1.23; Evidence=; Belongs to the glycosyl hydrolase 35 family. hydrolase activity, hydrolyzing O-glycosyl compounds beta-galactosidase activity carbohydrate metabolic process metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds uc009opw.1 uc009opw.2 uc009opw.3 uc009opw.4 
ENSMUST00000210275.2 Gm17655 ENSMUST00000210275.2 Nucleus (from UniProt A0A1B0GT13) A0A1B0GT13 A0A1B0GT13_MOUSE ENSMUST00000210275.1 Gm17655 uc290ycq.1 uc290ycq.2 Nucleus nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc290ycq.1 uc290ycq.2 
ENSMUST00000210279.2 Dcaf15 ENSMUST00000210279.2 DDB1 and CUL4 associated factor 15, transcript variant 2 (from RefSeq NM_001357322.1) DCA15_MOUSE Dcaf15 ENSMUST00000210279.1 NM_001357322 Q3U305 Q6PFH3 Q8BMB2 uc009mlx.1 uc009mlx.2 uc009mlx.3 Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins. The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3. May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells. Protein modification; protein ubiquitination. Component of the DCX(DCAF15) complex, also named CLR4(DCAF15) complex, composed of DCAF15, DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PFH3-1; Sequence=Displayed; Name=2; IsoId=Q6PFH3-2; Sequence=VSP_030290; molecular_function protein ubiquitination macromolecular complex Cul4-RING E3 ubiquitin ligase complex uc009mlx.1 uc009mlx.2 uc009mlx.3 
ENSMUST00000210282.2 Zbtb45 ENSMUST00000210282.2 May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (PubMed:21131782). (from UniProt Q52KG4) AK166382 ENSMUST00000210282.1 Gm157 Q3TLP9 Q52KG4 ZBT45_MOUSE Zbtb45 Zfp499 uc009fez.1 uc009fez.2 uc009fez.3 May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (PubMed:21131782). Nucleus Detected in embryonic forebrain at stages 12.5 dpc and 14.5 dpc where it is ubiquitously expressed. Belongs to the krueppel C2H2-type zinc-finger protein family. RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus nervous system development biological_process metal ion binding uc009fez.1 uc009fez.2 uc009fez.3 
ENSMUST00000210288.2 Ins2 ENSMUST00000210288.2 Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (from UniProt Q5EEX1) AK007612 ENSMUST00000210288.1 Ins2 Q5EEX1 Q5EEX1_MOUSE uc291xkm.1 uc291xkm.2 Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds. Secreted Belongs to the insulin family. protease binding hormone activity extracellular region extracellular space carbohydrate metabolic process glucose metabolic process signal transduction secretory granule macromolecular complex binding uc291xkm.1 uc291xkm.2 
ENSMUST00000210290.2 Gm10153 ENSMUST00000210290.2 Gm10153 (from geneSymbol) A0A1B0GRL1 A0A1B0GRL1_MOUSE ENSMUST00000210290.1 Gm10153 uc291xho.1 uc291xho.2 molecular_function cellular_component biological_process keratin filament uc291xho.1 uc291xho.2 
ENSMUST00000210294.2 Gm10997 ENSMUST00000210294.2 Gm10997 (from geneSymbol) ENSMUST00000210294.1 uc292afx.1 uc292afx.2 uc292afx.1 uc292afx.2 
ENSMUST00000210295.2 Gm45533 ENSMUST00000210295.2 Gm45533 (from geneSymbol) ENSMUST00000210295.1 uc290rdu.1 uc290rdu.2 uc290rdu.1 uc290rdu.2 
ENSMUST00000210301.2 Gm45257 ENSMUST00000210301.2 Gm45257 (from geneSymbol) AK084207 ENSMUST00000210301.1 uc292cog.1 uc292cog.2 uc292cog.1 uc292cog.2 
ENSMUST00000210303.2 Gm38572 ENSMUST00000210303.2 Gm38572 (from geneSymbol) AK054526 ENSMUST00000210303.1 uc009ljm.1 uc009ljm.2 uc009ljm.1 uc009ljm.2 
ENSMUST00000210309.2 Usp47 ENSMUST00000210309.2 ubiquitin specific peptidase 47, transcript variant 1 (from RefSeq NM_177249.4) ENSMUST00000210309.1 NM_177249 Q32NY0 Q5EBP2 Q6KAR9 Q80V06 Q8BHU1 Q8BI15 Q8BI16 Q8BUW4 Q8BY87 Q91X25 UBP47_MOUSE uc009jgh.1 uc009jgh.2 uc009jgh.3 uc009jgh.4 Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER) (By similarity). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Interacts with BTRC and FBXW11. Interacts with POLB (By similarity). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BY87-1; Sequence=Displayed; Name=2; IsoId=Q8BY87-2; Sequence=VSP_014416; Belongs to the peptidase C19 family. USP47 subfamily. Sequence=BAC27179.1; Type=Erroneous initiation; Evidence=; Sequence=BAC27195.1; Type=Erroneous initiation; Evidence=; Sequence=BAC38411.1; Type=Frameshift; Evidence=; cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity cytoplasm DNA repair base-excision repair proteolysis ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus peptidase activity cysteine-type peptidase activity negative regulation of G2/M transition of mitotic cell cycle protein deubiquitination hydrolase activity SCF ubiquitin ligase complex positive regulation of cell growth cellular response to UV monoubiquitinated protein deubiquitination thiol-dependent ubiquitinyl hydrolase activity response to drug negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of transcription, DNA-templated WD40-repeat domain binding positive regulation of canonical Wnt signaling pathway ubiquitinyl hydrolase activity negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage uc009jgh.1 uc009jgh.2 uc009jgh.3 uc009jgh.4 
ENSMUST00000210310.2 Gm45484 ENSMUST00000210310.2 Gm45484 (from geneSymbol) ENSMUST00000210310.1 LF196947 uc292adi.1 uc292adi.2 uc292adi.1 uc292adi.2 
ENSMUST00000210317.2 Grtp1 ENSMUST00000210317.2 GH regulated TBC protein 1, transcript variant 1 (from RefSeq NM_025768.2) ENSMUST00000210317.1 GRTP1_MOUSE NM_025768 Q8BUR0 Q8VI03 Q9D3N8 Q9D3Q5 Q9D8L8 Tbc1d6 uc009kxd.1 uc009kxd.2 uc009kxd.3 May act as a GTPase-activating protein for Rab family protein(s). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9D3N8-1; Sequence=Displayed; Name=2; IsoId=Q9D3N8-2; Sequence=VSP_025757; Name=3; IsoId=Q9D3N8-3; Sequence=VSP_025756, VSP_025757; Name=4; IsoId=Q9D3N8-4; Sequence=VSP_025757, VSP_025758; Highly expressed in testes, expression greatly increased at postnatal day 20 and remained high up to day 90. Moderately expressed in kidney and liver, weakly expressed in intestine, lung, ovaries and stomach. Expression of Growth hormone increased the expression in testis but decreased expression in liver and kidney. Weakly expressed in the testis of the embryo and neonate. GTPase activator activity cell intracellular protein transport Rab GTPase binding activation of GTPase activity uc009kxd.1 uc009kxd.2 uc009kxd.3 
ENSMUST00000210325.2 Zfp873 ENSMUST00000210325.2 zinc finger protein 873, transcript variant 1 (from RefSeq NM_001319203.1) A0A1B0GT64 A0A1B0GT64_MOUSE ENSMUST00000210325.1 NM_001319203 Zfp873 uc057axd.1 uc057axd.2 uc057axd.3 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc057axd.1 uc057axd.2 uc057axd.3 
ENSMUST00000210331.2 Pfn5 ENSMUST00000210331.2 Belongs to the profilin family. (from UniProt A0A1B0GT24) A0A1B0GT24 A0A1B0GT24_MOUSE ENSMUST00000210331.1 Gm45800 Pfn5 uc292pne.1 uc292pne.2 Belongs to the profilin family. actin binding cytoplasm actin cytoskeleton organization regulation of actin filament polymerization positive regulation of actin filament bundle assembly uc292pne.1 uc292pne.2 
ENSMUST00000210335.2 Gm45869 ENSMUST00000210335.2 Gm45869 (from geneSymbol) ENSMUST00000210335.1 uc291jca.1 uc291jca.2 uc291jca.1 uc291jca.2 
ENSMUST00000210339.2 Gm36380 ENSMUST00000210339.2 Gm36380 (from geneSymbol) ENSMUST00000210339.1 uc292caj.1 uc292caj.2 uc292caj.1 uc292caj.2 
ENSMUST00000210342.2 Gm45532 ENSMUST00000210342.2 Gm45532 (from geneSymbol) AK141293 ENSMUST00000210342.1 uc291wnk.1 uc291wnk.2 uc291wnk.1 uc291wnk.2 
ENSMUST00000210357.4 Or13a26 ENSMUST00000210357.4 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGM0) ENSMUST00000210357.1 ENSMUST00000210357.2 ENSMUST00000210357.3 Olfr541 Or13a26 Q8VGM0 Q8VGM0_MOUSE uc009kib.1 uc009kib.2 uc009kib.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009kib.1 uc009kib.2 uc009kib.3 
ENSMUST00000210360.2 Gm45619 ENSMUST00000210360.2 Gm45619 (from geneSymbol) ENSMUST00000210360.1 uc291psi.1 uc291psi.2 uc291psi.1 uc291psi.2 
ENSMUST00000210377.2 Gm45263 ENSMUST00000210377.2 Gm45263 (from geneSymbol) AK043441 ENSMUST00000210377.1 uc291zxy.1 uc291zxy.2 uc291zxy.1 uc291zxy.2 
ENSMUST00000210380.2 Gm45667 ENSMUST00000210380.2 Gm45667 (from geneSymbol) ENSMUST00000210380.1 LF196496 uc291tyc.1 uc291tyc.2 uc291tyc.1 uc291tyc.2 
ENSMUST00000210381.2 Gm4924 ENSMUST00000210381.2 predicted gene 4924, transcript variant 4 (from RefSeq NM_001407609.1) A0A1B0GR71 A0A1B0GR71_MOUSE ENSMUST00000210381.1 Gm4924 NM_001407609 uc287tnt.1 uc287tnt.2 negative regulation of transcription from RNA polymerase II promoter nucleic acid binding transcription factor activity, sequence-specific DNA binding protein binding nucleus cytoplasm regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc287tnt.1 uc287tnt.2 
ENSMUST00000210384.2 4932411K12Rik ENSMUST00000210384.2 4932411K12Rik (from geneSymbol) AK029970 ENSMUST00000210384.1 uc288pph.1 uc288pph.2 uc288pph.1 uc288pph.2 
ENSMUST00000210389.2 Gm45413 ENSMUST00000210389.2 Gm45413 (from geneSymbol) AK137862 ENSMUST00000210389.1 uc291yzi.1 uc291yzi.2 uc291yzi.1 uc291yzi.2 
ENSMUST00000210390.2 Exosc6 ENSMUST00000210390.2 exosome component 6 (from RefSeq NM_028274.4) ENSMUST00000210390.1 EXOS6_MOUSE Mtr3 NM_028274 Q8BTW3 Q9CSR7 uc009nlp.1 uc009nlp.2 uc009nlp.3 Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity). Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure (By similarity). Cytoplasm Nucleus, nucleolus Nucleus Belongs to the RNase PH family. Sequence=BAB28033.1; Type=Frameshift; Evidence=; nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) RNA binding nucleus nucleolus cytoplasm rRNA processing rRNA catabolic process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U4 snRNA 3'-end processing DNA deamination isotype switching positive regulation of isotype switching nuclear mRNA surveillance polyadenylation-dependent snoRNA 3'-end processing uc009nlp.1 uc009nlp.2 uc009nlp.3 
ENSMUST00000210393.2 Gm45295 ENSMUST00000210393.2 Gm45295 (from geneSymbol) AK081498 ENSMUST00000210393.1 uc292caf.1 uc292caf.2 uc292caf.1 uc292caf.2 
ENSMUST00000210408.2 4930543E12Rik ENSMUST00000210408.2 RIKEN cDNA 4930543E12 gene (from RefSeq NR_045978.1) ENSMUST00000210408.1 NR_045978 uc009jhd.1 uc009jhd.2 uc009jhd.3 uc009jhd.4 uc009jhd.1 uc009jhd.2 uc009jhd.3 uc009jhd.4 
ENSMUST00000210409.2 9430099M06Rik ENSMUST00000210409.2 9430099M06Rik (from geneSymbol) AK020530 ENSMUST00000210409.1 uc292coh.1 uc292coh.2 uc292coh.1 uc292coh.2 
ENSMUST00000210412.2 Fbxl9 ENSMUST00000210412.2 F-box and leucine-rich repeat protein 9, transcript variant 2 (from RefSeq NM_001368409.1) A0A1B0GQY9 A0A1B0GQY9_MOUSE ENSMUST00000210412.1 Fbxl9 Lrrc29 NM_001368409 uc292cun.1 uc292cun.2 ubiquitin-dependent protein catabolic process protein ubiquitination SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein transferase activity uc292cun.1 uc292cun.2 
ENSMUST00000210417.2 Gm45615 ENSMUST00000210417.2 Gm45615 (from geneSymbol) ENSMUST00000210417.1 uc291upw.1 uc291upw.2 uc291upw.1 uc291upw.2 
ENSMUST00000210418.2 Gm45285 ENSMUST00000210418.2 Gm45285 (from geneSymbol) ENSMUST00000210418.1 uc292bec.1 uc292bec.2 uc292bec.1 uc292bec.2 
ENSMUST00000210429.2 Gm45663 ENSMUST00000210429.2 Gm45663 (from geneSymbol) AK135722 ENSMUST00000210429.1 uc292cor.1 uc292cor.2 uc292cor.1 uc292cor.2 
ENSMUST00000210431.3 Or52s19 ENSMUST00000210431.3 Membrane ; Multi- pass membrane protein (from UniProt A2RS33) A2RS33 A2RS33_MOUSE ENSMUST00000210431.1 ENSMUST00000210431.2 Olfr601 Or52s19 uc291tqc.1 uc291tqc.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tqc.1 uc291tqc.2 
ENSMUST00000210432.2 Gm45512 ENSMUST00000210432.2 Gm45512 (from geneSymbol) AK085976 ENSMUST00000210432.1 uc291zqe.1 uc291zqe.2 uc291zqe.1 uc291zqe.2 
ENSMUST00000210433.2 Gm32742 ENSMUST00000210433.2 Gm32742 (from geneSymbol) A0A1B0GT42 A0A1B0GT42_MOUSE ENSMUST00000210433.1 Gm32742 uc292hfp.1 uc292hfp.2 uc292hfp.1 uc292hfp.2 
ENSMUST00000210435.4 Or1ab2 ENSMUST00000210435.4 olfactory receptor family 1 subfamily AB member 2 (from RefSeq NM_146338.2) A0A1B0GRP2 ENSMUST00000210435.1 ENSMUST00000210435.2 ENSMUST00000210435.3 NM_146338 Olfr374 Or1ab2 Q7TRY0 Q7TRY0_MOUSE uc009mfh.1 uc009mfh.2 uc009mfh.3 uc009mfh.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DR065548.1, DR065957.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009mfh.1 uc009mfh.2 uc009mfh.3 uc009mfh.4 
ENSMUST00000210436.2 Gm45310 ENSMUST00000210436.2 Gm45310 (from geneSymbol) ENSMUST00000210436.1 LF196316 uc291qal.1 uc291qal.2 uc291qal.1 uc291qal.2 
ENSMUST00000210446.3 Gm39132 ENSMUST00000210446.3 Gm39132 (from geneSymbol) ENSMUST00000210446.1 ENSMUST00000210446.2 uc291yfi.1 uc291yfi.2 uc291yfi.3 uc291yfi.1 uc291yfi.2 uc291yfi.3 
ENSMUST00000210452.2 Gm45343 ENSMUST00000210452.2 Gm45343 (from geneSymbol) ENSMUST00000210452.1 uc291yxk.1 uc291yxk.2 uc291yxk.1 uc291yxk.2 
ENSMUST00000210456.2 Gm45542 ENSMUST00000210456.2 Gm45542 (from geneSymbol) ENSMUST00000210456.1 uc291zot.1 uc291zot.2 uc291zot.1 uc291zot.2 
ENSMUST00000210463.2 Gm2788 ENSMUST00000210463.2 Gm2788 (from geneSymbol) BC079901 ENSMUST00000210463.1 uc291qfu.1 uc291qfu.2 uc291qfu.1 uc291qfu.2 
ENSMUST00000210473.3 ENSMUSG00000121391 ENSMUST00000210473.3 ENSMUSG00000121391 (from geneSymbol) ENSMUST00000210473.1 ENSMUST00000210473.2 uc291ljw.1 uc291ljw.2 uc291ljw.3 uc291ljw.1 uc291ljw.2 uc291ljw.3 
ENSMUST00000210477.2 Prdm8 ENSMUST00000210477.2 PR domain containing 8, transcript variant 3 (from RefSeq NM_001407995.1) B2RU90 ENSMUST00000210477.1 NM_001407995 PRDM8_MOUSE Q8BZ97 uc290xiv.1 uc290xiv.2 Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (PubMed:19646955). Histone methyltransferase activity has not been confirmed in other species. Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (PubMed:19646955). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (PubMed:22284184). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (PubMed:26023183). Interacts with BHLHE22 (PubMed:22284184). Interacts with EPM2A and NHLRC1. This interaction sequesters EPM2A and NHLRC1 to the nucleus (By similarity). Nucleus Expressed in brain, heart, liver, testes, retina (PubMed:19646955, PubMed:22284184). Highest expression is observed in the retina and hippocampus; moderately expressed in the cortex and cerebellum. In the retina, it is expressed in bipolar and amacrine cells (PubMed:26023183). Knockout mice lacking PRDM8 shows absence of the corticospinal tract, agenesis of the corpus callosum and hippocampal commissure; they have an abnormal itching behavior that results in the formation of skin lesions, and occasionally display an unusual movement in which they walk on their forepaws (PubMed:22284184). PRDM8-null mice also have a non-progressive defect in retinal responses, and loss of rod bipolar and type 2 OFF-cone bipolar cells (PubMed:26023183). Belongs to the class V-like SAM-binding methyltransferase superfamily. Sequence=BAC29345.1; Type=Frameshift; Evidence=; nucleic acid binding DNA binding chromatin binding transcription corepressor activity protein binding nucleus nervous system development methyltransferase activity oligodendrocyte development histone methylation transferase activity corpus callosum morphogenesis central nervous system projection neuron axonogenesis corticospinal tract morphogenesis neurogenesis methylation histone methyltransferase complex histone methyltransferase activity negative regulation of transcription, DNA-templated metal ion binding histone methyltransferase activity (H3-K9 specific) histone H3-K9 methylation uc290xiv.1 uc290xiv.2 
ENSMUST00000210482.2 Gm5535 ENSMUST00000210482.2 Gm5535 (from geneSymbol) AK144672 ENSMUST00000210482.1 uc290ayt.1 uc290ayt.2 uc290ayt.1 uc290ayt.2 
ENSMUST00000210484.2 Gm45280 ENSMUST00000210484.2 Gm45280 (from geneSymbol) ENSMUST00000210484.1 LF196655 uc291won.1 uc291won.2 uc291won.1 uc291won.2 
ENSMUST00000210487.3 Gm36325 ENSMUST00000210487.3 Gm36325 (from geneSymbol) ENSMUST00000210487.1 ENSMUST00000210487.2 uc292cai.1 uc292cai.2 uc292cai.3 uc292cai.1 uc292cai.2 uc292cai.3 
ENSMUST00000210490.3 Igip ENSMUST00000210490.3 IgA inducing protein (from RefSeq NM_001267796.1) A0A1B0GR74 A0A1B0GR74_MOUSE ENSMUST00000210490.1 ENSMUST00000210490.2 Igip NM_001267796 uc033hge.1 uc033hge.2 uc033hge.3 uc033hge.4 molecular_function cellular_component biological_process uc033hge.1 uc033hge.2 uc033hge.3 uc033hge.4 
ENSMUST00000210497.2 Gm45636 ENSMUST00000210497.2 Gm45636 (from geneSymbol) ENSMUST00000210497.1 uc292acb.1 uc292acb.2 uc292acb.1 uc292acb.2 
ENSMUST00000210502.2 Gm7562 ENSMUST00000210502.2 Gm7562 (from geneSymbol) ENSMUST00000210502.1 uc291yel.1 uc291yel.2 uc291yel.1 uc291yel.2 
ENSMUST00000210508.2 Gm45332 ENSMUST00000210508.2 Gm45332 (from geneSymbol) ENSMUST00000210508.1 uc292cat.1 uc292cat.2 uc292cat.1 uc292cat.2 
ENSMUST00000210529.2 Tex53 ENSMUST00000210529.2 testis expressed 53, transcript variant 1 (from RefSeq NM_001354647.1) A0A1B0GR83 A0A1B0GR83_MOUSE ENSMUST00000210529.1 Gm11213 NM_001354647 Tex53 uc008tgx.1 uc008tgx.2 uc008tgx.1 uc008tgx.2 
ENSMUST00000210537.2 Krtap5-25 ENSMUST00000210537.2 predicted gene 45337 (from RefSeq NM_001378699.1) A0A1B0GS71 A0A1B0GS71_MOUSE ENSMUST00000210537.1 Gm45337 NM_001378699 uc291xhi.1 uc291xhi.2 intermediate filament keratin filament uc291xhi.1 uc291xhi.2 
ENSMUST00000210548.2 Gm17949 ENSMUST00000210548.2 Belongs to the adenylate kinase family. (from UniProt A0A1B0GRV7) A0A1B0GRV7 A0A1B0GRV7_MOUSE ENSMUST00000210548.1 Gm17949 uc289med.1 uc289med.2 Belongs to the adenylate kinase family. ATP binding nucleobase-containing compound metabolic process kinase activity phosphorylation transferase activity nucleobase-containing compound kinase activity uc289med.1 uc289med.2 
ENSMUST00000210549.2 Gm45277 ENSMUST00000210549.2 Gm45277 (from geneSymbol) AK135993 ENSMUST00000210549.1 uc292con.1 uc292con.2 uc292con.1 uc292con.2 
ENSMUST00000210553.2 Gm31983 ENSMUST00000210553.2 Gm31983 (from geneSymbol) ENSMUST00000210553.1 uc291zaj.1 uc291zaj.2 uc291zaj.1 uc291zaj.2 
ENSMUST00000210559.2 Zscan4-ps3 ENSMUST00000210559.2 Chromosome, telomere Nucleus (from UniProt A0A1B0GRH6) A0A1B0GRH6 A0A1B0GRH6_MOUSE ENSMUST00000210559.1 Zscan4-ps3 uc291lln.1 uc291lln.2 Chromosome, telomere Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc291lln.1 uc291lln.2 
ENSMUST00000210560.2 Gm45350 ENSMUST00000210560.2 Gm45350 (from geneSymbol) ENSMUST00000210560.1 uc291zhf.1 uc291zhf.2 uc291zhf.1 uc291zhf.2 
ENSMUST00000210564.3 Chmp1b ENSMUST00000210564.3 charged multivesicular body protein 1B (from RefSeq NM_024190.2) CH1B1_MOUSE Chmp1b1 ENSMUST00000210564.1 ENSMUST00000210564.2 NM_024190 Q3UB77 Q99LU0 Q9CXR5 uc008flu.1 uc008flu.2 uc008flu.3 uc008flu.4 uc008flu.5 Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells (By similarity). Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with CHMP1A. Interacts with VTA1; the interaction probably involves the open conformation of CHMP1B. Interacts with CHMP2A. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with SPAST (via MIT domain); the interaction is direct. Interacts with IST1. Interacts with MITD1. Interacts with STAMBP (By similarity). Cytoplasm, cytosol Endosome Late endosome membrane ; Peripheral membrane protein Note=Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body (By similarity). Belongs to the SNF7 family. ESCRT III complex nucleus cytoplasm endosome multivesicular body cytosol nucleus organization vacuolar transport cell cycle mitotic metaphase plate congression endosome membrane regulation of centrosome duplication protein transport membrane protein domain specific binding membrane coat midbody late endosome membrane endosome transport via multivesicular body sorting pathway viral budding via host ESCRT complex identical protein binding establishment of protein localization late endosome to vacuole transport cell division regulation of mitotic spindle assembly uc008flu.1 uc008flu.2 uc008flu.3 uc008flu.4 uc008flu.5 
ENSMUST00000210568.4 Or10a4 ENSMUST00000210568.4 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRM9) E9PVA4 ENSMUST00000210568.1 ENSMUST00000210568.2 ENSMUST00000210568.3 Olfr17 Olfr713 Or10a4 Q7TRM9 Q7TRM9_MOUSE uc291uef.1 uc291uef.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway axon guidance sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uef.1 uc291uef.2 
ENSMUST00000210575.2 Gm45424 ENSMUST00000210575.2 Gm45424 (from geneSymbol) AK132572 ENSMUST00000210575.1 uc292btl.1 uc292btl.2 uc292btl.1 uc292btl.2 
ENSMUST00000210579.2 Lnp1 ENSMUST00000210579.2 leukemia NUP98 fusion partner 1 (from RefSeq NM_001347042.1) A0A1B0GSK3 A0A1B0GSK3_MOUSE ENSMUST00000210579.1 Lnp1 NM_001347042 uc057kvn.1 uc057kvn.2 uc057kvn.3 uc057kvn.1 uc057kvn.2 uc057kvn.3 
ENSMUST00000210581.2 Gm45353 ENSMUST00000210581.2 Gm45353 (from geneSymbol) ENSMUST00000210581.1 uc292dse.1 uc292dse.2 uc292dse.1 uc292dse.2 
ENSMUST00000210582.2 D830025C05Rik ENSMUST00000210582.2 D830025C05Rik (from geneSymbol) AK085892 ENSMUST00000210582.1 uc291yxe.1 uc291yxe.2 uc291yxe.1 uc291yxe.2 
ENSMUST00000210594.2 Clcn4 ENSMUST00000210594.2 chloride channel, voltage-sensitive 4, transcript variant 16 (from RefSeq NM_001412266.1) Clcn4 Clcn4-2 ENSMUST00000210594.1 NM_001412266 Q3LRV6 Q3LRV6_MOUSE uc291les.1 uc291les.2 Endosome membrane ; Multi-pass membrane protein Membrane ; Multi- pass membrane protein Belongs to the chloride channel (TC 2.A.49) family. Lacks conserved residue(s) required for the propagation of feature annotation. voltage-gated chloride channel activity ion transport chloride transport membrane integral component of membrane transmembrane transport chloride transmembrane transport uc291les.1 uc291les.2 
ENSMUST00000210597.2 ENSMUSG00000121385 ENSMUST00000210597.2 ENSMUSG00000121385 (from geneSymbol) ENSMUST00000210597.1 uc291lga.1 uc291lga.2 uc291lga.1 uc291lga.2 
ENSMUST00000210598.2 Folr2 ENSMUST00000210598.2 folate receptor beta, transcript variant 1 (from RefSeq NM_001303239.1) ENSMUST00000210598.1 FOLR2_MOUSE Fbp2 Folbp2 NM_001303239 Q05685 uc057ait.1 uc057ait.2 uc057ait.3 This gene encodes a receptor protein located on the plasma membrane that mediates folate uptake by cells. Mice lacking the product of this gene show no defects in embryonic development and grow normally into fertile adults. However, such mice were found to be highly susceptible to the teratogenic effects of arsenic. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity). Cell membrane ; Lipid-anchor, GPI- anchor No visible phenotype. Belongs to the folate receptor family. folic acid binding plasma membrane posttranslational protein targeting to membrane drug binding positive regulation of cell proliferation cell surface folic acid transport membrane anchored component of membrane anchored component of external side of plasma membrane signaling receptor activity methotrexate binding folic acid receptor activity cellular response to folic acid folic acid import into cell uc057ait.1 uc057ait.2 uc057ait.3 
ENSMUST00000210611.2 Gm45507 ENSMUST00000210611.2 Gm45507 (from geneSymbol) ENSMUST00000210611.1 uc291wpu.1 uc291wpu.2 uc291wpu.1 uc291wpu.2 
ENSMUST00000210640.2 Rpl18 ENSMUST00000210640.2 Rough endoplasmic reticulum (from UniProt Q58EW0) BC072558 ENSMUST00000210640.1 Q58EW0 Q58EW0_MOUSE Rpl18 uc009gww.1 uc009gww.2 uc009gww.3 Rough endoplasmic reticulum Belongs to the eukaryotic ribosomal protein eL18 family. cytoplasmic translation structural constituent of ribosome nucleolus endoplasmic reticulum cytosol ribosome translation cytosolic large ribosomal subunit polysomal ribosome uc009gww.1 uc009gww.2 uc009gww.3 
ENSMUST00000210646.2 Gvin-ps1 ENSMUST00000210646.2 Gvin-ps1 (from geneSymbol) AK020274 ENSMUST00000210646.1 uc291ubn.1 uc291ubn.2 uc291ubn.1 uc291ubn.2 
ENSMUST00000210650.2 Zscan18 ENSMUST00000210650.2 zinc finger and SCAN domain containing 18, transcript variant 2 (from RefSeq NM_001382523.1) E9PUD6 E9PUD6_MOUSE ENSMUST00000210650.1 NM_001382523 Zscan18 uc291lpm.1 uc291lpm.2 Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc291lpm.1 uc291lpm.2 
ENSMUST00000210654.2 Gm38590 ENSMUST00000210654.2 Gm38590 (from geneSymbol) ENSMUST00000210654.1 uc292bio.1 uc292bio.2 uc292bio.1 uc292bio.2 
ENSMUST00000210656.2 Ap3m2 ENSMUST00000210656.2 adaptor-related protein complex 3, mu 2 subunit, transcript variant 2 (from RefSeq NM_029505.3) AP3M2_MOUSE ENSMUST00000210656.1 NM_029505 Q3UYJ3 Q8R2R9 Q923G7 uc009ldz.1 uc009ldz.2 uc009ldz.3 uc009ldz.4 Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Ap47 is a subunit of the plasma membrane adaptor (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). AP- 3 associates with the BLOC-1 complex. Golgi apparatus. Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Belongs to the adaptor complexes medium subunit family. Golgi apparatus intracellular protein transport anterograde axonal transport protein transport membrane vesicle-mediated transport clathrin adaptor complex cytoplasmic vesicle membrane cytoplasmic vesicle anterograde synaptic vesicle transport axon cytoplasm uc009ldz.1 uc009ldz.2 uc009ldz.3 uc009ldz.4 
ENSMUST00000210663.2 Gm36210 ENSMUST00000210663.2 predicted gene, 36210 (from RefSeq NM_001370858.1) A0A1B0GS00 A0A1B0GS00_MOUSE ENSMUST00000210663.1 Gm36210 NM_001370858 uc291kxf.1 uc291kxf.2 uc291kxf.1 uc291kxf.2 
ENSMUST00000210665.2 Gm45640 ENSMUST00000210665.2 Gm45640 (from geneSymbol) ENSMUST00000210665.1 uc292bye.1 uc292bye.2 uc292bye.1 uc292bye.2 
ENSMUST00000210666.2 Gm45242 ENSMUST00000210666.2 Gm45242 (from geneSymbol) ENSMUST00000210666.1 uc292agd.1 uc292agd.2 uc292agd.1 uc292agd.2 
ENSMUST00000210669.2 Gm45633 ENSMUST00000210669.2 Gm45633 (from geneSymbol) ENSMUST00000210669.1 uc292abs.1 uc292abs.2 uc292abs.1 uc292abs.2 
ENSMUST00000210674.2 Gm34730 ENSMUST00000210674.2 Gm34730 (from geneSymbol) ENSMUST00000210674.1 uc292acn.1 uc292acn.2 uc292acn.1 uc292acn.2 
ENSMUST00000210676.2 Gab1 ENSMUST00000210676.2 growth factor receptor bound protein 2-associated protein 1, transcript variant 1 (from RefSeq NM_001301298.2) A0A1B0GS41 A0A1B0GS41_MOUSE ENSMUST00000210676.1 Gab1 NM_001301298 uc009mjc.1 uc009mjc.2 uc009mjc.3 uc009mjc.4 Belongs to the GAB family. angiogenesis cell-cell junction actin cytoskeleton reorganization response to hepatocyte growth factor vascular endothelial growth factor signaling pathway positive regulation of angiogenesis endothelial cell chemotaxis to vascular endothelial growth factor uc009mjc.1 uc009mjc.2 uc009mjc.3 uc009mjc.4 
ENSMUST00000210682.2 Nup98 ENSMUST00000210682.2 nucleoporin 98, transcript variant 8 (from RefSeq NM_001404136.1) A0A1B0GSX7 A0A1B0GSX7_MOUSE ENSMUST00000210682.1 NM_001404136 Nup98 uc009iqx.1 uc009iqx.2 uc009iqx.3 uc009iqx.4 Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side Nucleus, nuclear pore complex Belongs to the nucleoporin GLFG family. kinetochore transcription coactivator activity mRNA binding nuclear envelope nuclear pore nucleoplasm protein import into nucleus nucleocytoplasmic transport nuclear localization sequence binding nuclear body structural constituent of nuclear pore nuclear pore outer ring nuclear membrane nuclear periphery peptide binding nuclear inclusion body intracellular membrane-bounded organelle nuclear pore nuclear basket positive regulation of mRNA splicing, via spliceosome nuclear pore complex assembly positive regulation of nucleic acid-templated transcription promoter-specific chromatin binding ribonucleoprotein complex uc009iqx.1 uc009iqx.2 uc009iqx.3 uc009iqx.4 
ENSMUST00000210685.2 Gm45294 ENSMUST00000210685.2 Gm45294 (from geneSymbol) AK052213 ENSMUST00000210685.1 uc292cac.1 uc292cac.2 uc292cac.1 uc292cac.2 
ENSMUST00000210686.2 Or52s1 ENSMUST00000210686.2 Membrane ; Multi- pass membrane protein (from UniProt Q7TRR5) ENSMUST00000210686.1 Olfr593 Or52s1 Q7TRR5 Q7TRR5_MOUSE uc291tpp.1 uc291tpp.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tpp.1 uc291tpp.2 
ENSMUST00000210689.2 Gm45556 ENSMUST00000210689.2 Gm45556 (from geneSymbol) ENSMUST00000210689.1 uc291tvd.1 uc291tvd.2 uc291tvd.1 uc291tvd.2 
ENSMUST00000210690.2 Prrg2 ENSMUST00000210690.2 proline-rich Gla (G-carboxyglutamic acid) polypeptide 2, transcript variant 7 (from RefSeq NR_185003.1) ENSMUST00000210690.1 N4wbp1 NR_185003 Q8R182 Q9EQI2 TMG2_MOUSE uc009gsw.1 uc009gsw.2 uc009gsw.3 uc009gsw.4 Interacts with NEDD4 (PubMed:11042109). Interacts with transcriptional coactivator YAP1 (By similarity). Q8R182; P46935: Nedd4; NbExp=5; IntAct=EBI-6304055, EBI-773516; Cell membrane ; Single-pass type I membrane protein Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. calcium ion binding protein binding extracellular region extracellular space biological_process membrane integral component of membrane uc009gsw.1 uc009gsw.2 uc009gsw.3 uc009gsw.4 
ENSMUST00000210693.2 Gm45418 ENSMUST00000210693.2 Gm45418 (from geneSymbol) ENSMUST00000210693.1 uc292aea.1 uc292aea.2 uc292aea.1 uc292aea.2 
ENSMUST00000210694.2 Gm45253 ENSMUST00000210694.2 Gm45253 (from geneSymbol) ENSMUST00000210694.1 uc291zrx.1 uc291zrx.2 uc291zrx.1 uc291zrx.2 
ENSMUST00000210698.2 Gm45360 ENSMUST00000210698.2 Gm45360 (from geneSymbol) AK033280 ENSMUST00000210698.1 uc292abg.1 uc292abg.2 uc292abg.1 uc292abg.2 
ENSMUST00000210701.2 Gm45808 ENSMUST00000210701.2 Belongs to the Gfo/Idh/MocA family. (from UniProt A0A1B0GSH8) A0A1B0GSH8 A0A1B0GSH8_MOUSE BC116414 ENSMUST00000210701.1 Gm45808 uc291pub.1 uc291pub.2 Belongs to the Gfo/Idh/MocA family. D-xylose catabolic process regulation of apoptotic process D-xylose 1-dehydrogenase (NADP+) activity oxidation-reduction process uc291pub.1 uc291pub.2 
ENSMUST00000210714.2 Spem3 ENSMUST00000210714.2 SPEM family member 3 (from RefSeq NM_001378260.1) A0A1B0GT45 A0A1B0GT45_MOUSE ENSMUST00000210714.1 Gm39566 NM_001378260 Spem3 uc287zka.1 uc287zka.2 Membrane ; Single- pass membrane protein membrane integral component of membrane uc287zka.1 uc287zka.2 
ENSMUST00000210717.3 5430403N17Rik ENSMUST00000210717.3 RIKEN cDNA 5430403N17 gene (from RefSeq NR_046181.1) ENSMUST00000210717.1 ENSMUST00000210717.2 NR_046181 uc029wsi.1 uc029wsi.2 uc029wsi.3 uc029wsi.1 uc029wsi.2 uc029wsi.3 
ENSMUST00000210718.3 Gm45613 ENSMUST00000210718.3 Gm45613 (from geneSymbol) ENSMUST00000210718.1 ENSMUST00000210718.2 uc291wqe.1 uc291wqe.2 uc291wqe.3 uc291wqe.1 uc291wqe.2 uc291wqe.3 
ENSMUST00000210720.3 Cylc1 ENSMUST00000210720.3 cylicin, basic protein of sperm head cytoskeleton 1 (from RefSeq NM_026134.3) A0A1B0GR13 A0A1B0GR13_MOUSE Cylc1 ENSMUST00000210720.1 ENSMUST00000210720.2 NM_026134 uc292qdk.1 uc292qdk.2 molecular_function structural constituent of cytoskeleton cytoskeleton organization biological_process acrosomal matrix uc292qdk.1 uc292qdk.2 
ENSMUST00000210722.3 Tmem274 ENSMUST00000210722.3 transmembrame protein 274 (from RefSeq NM_001366402.1) A0A2R8VH94 A0A2R8VH94_MOUSE ENSMUST00000210722.1 ENSMUST00000210722.2 NM_001366402 Tm274 Tmem274 uc290ryi.1 uc290ryi.2 membrane integral component of membrane uc290ryi.1 uc290ryi.2 
ENSMUST00000210723.2 Gm45371 ENSMUST00000210723.2 Gm45371 (from geneSymbol) ENSMUST00000210723.1 uc291zax.1 uc291zax.2 uc291zax.1 uc291zax.2 
ENSMUST00000210728.2 Gm45464 ENSMUST00000210728.2 Gm45464 (from geneSymbol) ENSMUST00000210728.1 uc292byy.1 uc292byy.2 uc292byy.1 uc292byy.2 
ENSMUST00000210729.2 Gm45436 ENSMUST00000210729.2 Gm45436 (from geneSymbol) ENSMUST00000210729.1 uc291lrt.1 uc291lrt.2 uc291lrt.1 uc291lrt.2 
ENSMUST00000210735.3 Gm45463 ENSMUST00000210735.3 Gm45463 (from geneSymbol) ENSMUST00000210735.1 ENSMUST00000210735.2 uc292cbq.1 uc292cbq.2 uc292cbq.3 uc292cbq.1 uc292cbq.2 uc292cbq.3 
ENSMUST00000210736.2 3110080E11Rik ENSMUST00000210736.2 3110080E11Rik (from geneSymbol) AK140833 ENSMUST00000210736.1 uc291ynh.1 uc291ynh.2 uc291ynh.1 uc291ynh.2 
ENSMUST00000210738.3 Gm53058 ENSMUST00000210738.3 Gm53058 (from geneSymbol) ENSMUST00000210738.1 ENSMUST00000210738.2 uc289cnc.1 uc289cnc.2 uc289cnc.3 uc289cnc.1 uc289cnc.2 uc289cnc.3 
ENSMUST00000210744.2 Smim32 ENSMUST00000210744.2 small integral membrane protein 32 (from RefSeq NM_001378296.1) A0A1B0GSF6 A0A1B0GSF6_MOUSE ENSMUST00000210744.1 Gm45623 NM_001378296 Smim32 uc288neq.1 uc288neq.2 membrane integral component of membrane uc288neq.1 uc288neq.2 
ENSMUST00000210760.2 Gm39232 ENSMUST00000210760.2 Gm39232 (from geneSymbol) ENSMUST00000210760.1 uc292cob.1 uc292cob.2 uc292cob.1 uc292cob.2 
ENSMUST00000210769.2 Saa2 ENSMUST00000210769.2 Major acute phase reactant. (from UniProt P05367) ENSMUST00000210769.1 M11130 P05367 SAA2_MOUSE Saa2 uc009gzb.1 uc009gzb.2 uc009gzb.3 uc009gzb.4 Major acute phase reactant. Apolipoprotein of the HDL complex. Secreted Expressed by the liver; secreted in plasma. Belongs to the SAA family. G-protein coupled receptor binding protein binding extracellular region extracellular space cytoplasmic microtubule acute-phase response high-density lipoprotein particle response to stilbenoid chemoattractant activity positive chemotaxis cell chemotaxis uc009gzb.1 uc009gzb.2 uc009gzb.3 uc009gzb.4 
ENSMUST00000210774.2 Ebf3 ENSMUST00000210774.2 early B cell factor 3, transcript variant 1 (from RefSeq NM_001113415.2) COE3_MOUSE Coe3 ENSMUST00000210774.1 NM_001113415 O08791 O08793 uc012fvm.1 uc012fvm.2 uc012fvm.3 Transcriptional activator (PubMed:9151732). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). Forms either a homodimer or a heterodimer with a related family member. Nucleus Event=Alternative splicing; Named isoforms=2; Name=Long; Synonyms=9L; IsoId=O08791-1; Sequence=Displayed; Name=Short; Synonyms=0S; IsoId=O08791-2; Sequence=VSP_001115, VSP_001116; Highly expressed in adult olfactory epithelium. In embryo, expressed in epithalamus, hypothalamus, throughout the brainstem and near the ventricular zones of mesencephalon, in rostral rhombencephalon, in vomeronasal organ, at high level in developing retina, developing spinal cord, at low level in dorsal root ganglia, trigeminal ganglia, glossopharyngeal nerve ganglia. Not expressed in developing inner eat. First detected at 9.5 dpc. Belongs to the COE family. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated multicellular organism development positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding protein dimerization activity uc012fvm.1 uc012fvm.2 uc012fvm.3 
ENSMUST00000210776.2 Gm45518 ENSMUST00000210776.2 Gm45518 (from geneSymbol) AK145573 ENSMUST00000210776.1 uc292afo.1 uc292afo.2 uc292afo.1 uc292afo.2 
ENSMUST00000210779.2 Or51f23c-ps1 ENSMUST00000210779.2 Or51f23c-ps1 (from geneSymbol) ENSMUST00000210779.1 NR_190795 uc291tnx.1 uc291tnx.2 uc291tnx.1 uc291tnx.2 
ENSMUST00000210780.2 Slc16a7 ENSMUST00000210780.2 Reaction=(R)-3-hydroxybutanoate(out) + H(+)(out) = (R)-3- hydroxybutanoate(in) + H(+)(in); Xref=Rhea:RHEA:71795, ChEBI:CHEBI:10983, ChEBI:CHEBI:15378; Evidence=; (from UniProt Q149G3) AF058054 ENSMUST00000210780.1 Q149G3 Q149G3_MOUSE Slc16a7 uc287vjp.1 uc287vjp.2 Reaction=(R)-3-hydroxybutanoate(out) + H(+)(out) = (R)-3- hydroxybutanoate(in) + H(+)(in); Xref=Rhea:RHEA:71795, ChEBI:CHEBI:10983, ChEBI:CHEBI:15378; Evidence=; Reaction=(S)-3-hydroxybutanoate(out) + H(+)(out) = (S)-3- hydroxybutanoate(in) + H(+)(in); Xref=Rhea:RHEA:71871, ChEBI:CHEBI:11047, ChEBI:CHEBI:15378; Evidence=; Reaction=(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out); Xref=Rhea:RHEA:29415, ChEBI:CHEBI:15378, ChEBI:CHEBI:16651; Evidence=; Reaction=3-methyl-2-oxobutanoate(out) + H(+)(out) = 3-methyl-2- oxobutanoate(in) + H(+)(in); Xref=Rhea:RHEA:71783, ChEBI:CHEBI:11851, ChEBI:CHEBI:15378; Evidence=; Reaction=4-methyl-2-oxopentanoate(out) + H(+)(out) = 4-methyl-2- oxopentanoate(in) + H(+)(in); Xref=Rhea:RHEA:71779, ChEBI:CHEBI:15378, ChEBI:CHEBI:17865; Evidence=; Reaction=H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in); Xref=Rhea:RHEA:64720, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64721; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64722; Evidence=; Reaction=acetoacetate(out) + H(+)(out) = acetoacetate(in) + H(+)(in); Xref=Rhea:RHEA:71775, ChEBI:CHEBI:13705, ChEBI:CHEBI:15378; Evidence=; Basolateral cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Cytoplasm Lateral cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein integral component of plasma membrane monocarboxylic acid transmembrane transporter activity lactate transmembrane transporter activity monocarboxylic acid transport membrane integral component of membrane lactate transmembrane transport pyruvate transmembrane transporter activity transmembrane transport pyruvate transmembrane transport uc287vjp.1 uc287vjp.2 
ENSMUST00000210781.2 Bicra ENSMUST00000210781.2 Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP- dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (By similarity). (from UniProt F8VPZ9) BC167213 BICRA_MOUSE Bicra ENSMUST00000210781.1 F8VPZ9 Gltscr1 uc291lza.1 uc291lza.2 Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP- dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (By similarity). Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). Interacts with BRD4; the interaction bridges BRD4 to the GBAF complex (By similarity). Nucleus transcription coactivator activity nucleus SWI/SNF complex positive regulation of transcription, DNA-templated uc291lza.1 uc291lza.2 
ENSMUST00000210789.3 Prpf40a ENSMUST00000210789.3 pre-mRNA processing factor 40A, transcript variant 7 (from RefSeq NM_001371020.1) A0A1B0GRU8 A0A1B0GRU8_MOUSE ENSMUST00000210789.1 ENSMUST00000210789.2 NM_001371020 Prpf40a uc008jrl.1 uc008jrl.2 uc008jrl.3 mRNA cis splicing, via spliceosome uc008jrl.1 uc008jrl.2 uc008jrl.3 
ENSMUST00000210796.2 Gm45515 ENSMUST00000210796.2 Gm45515 (from geneSymbol) AK041454 ENSMUST00000210796.1 uc291uks.1 uc291uks.2 uc291uks.1 uc291uks.2 
ENSMUST00000210802.2 D630033O11Rik ENSMUST00000210802.2 D630033O11Rik (from geneSymbol) AK143856 ENSMUST00000210802.1 uc292gjn.1 uc292gjn.2 uc292gjn.1 uc292gjn.2 
ENSMUST00000210805.2 Zfp541 ENSMUST00000210805.2 zinc finger protein 541, transcript variant 1 (from RefSeq NM_001347559.1) B2RXS6 ENSMUST00000210805.1 NM_001347559 Q0GGX2 Ship1 ZN541_MOUSE Znf541 uc012fab.1 uc012fab.2 uc012fab.3 Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes (PubMed:18849567, PubMed:35341968, PubMed:34075040, PubMed:33961623, PubMed:35320728). Regulates progression of the pachytene stage of meiotic prophase by activating the expression of genes involved in meiosis and post-meiosis during spermatogenesis (PubMed:35341968). Maintains the repression of pre-pachytene transcriptional programs, including meiotic double-strand breaks (DSB) formation genes in pachytene spermatocytes and suppresses aberrant DSB formation after mid-pachytene, thus ensuring meiosis progression (PubMed:35320728). Interacts with DNTTIP1 (PubMed:18849567). Identified in a complex with KCTD19, HDAC1 and HSPA2 (PubMed:18849567). Identified in a complex with HDAC1, HDAC2, DNTTIP1 and KCTD19 (PubMed:33961623, PubMed:35341968). Identified in a complex with KCTD19 and HDAC1 (PubMed:33961623). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0GGX2-1; Sequence=Displayed; Name=2; IsoId=Q0GGX2-2; Sequence=VSP_036221; Germ-cell-specific. Specifically present in testicular spermatogenic cells, but not in testicular and mature sperm. During spermatogenesis, it is present in spermatocytes and round spermatids only (at protein level). Females exhibit normal fertility with no apparent defects in ovaries while males are infertile with a small testis and an absence of spermatids and spermatozoa (PubMed:33961623, PubMed:34075040, PubMed:35320728, PubMed:35341968). Spermatocytes fail to complete meiotic prophase (PubMed:34075040). An aberrant recruitment of DNA double-strand breaks (DSBs) machinery and generation of massive DSBs seen in spermatocytes after mid-pachytene (PubMed:35320728, PubMed:35341968). histone deacetylase complex nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated multicellular organism development spermatogenesis transcription factor binding cell differentiation transcription regulatory region DNA binding metal ion binding uc012fab.1 uc012fab.2 uc012fab.3 
ENSMUST00000210812.2 Anapc10 ENSMUST00000210812.2 anaphase promoting complex subunit 10, transcript variant 4 (from RefSeq NM_001357236.1) APC10_MOUSE Apc10 ENSMUST00000210812.1 NM_001357236 Q8K2H6 Q9CW24 uc009miw.1 uc009miw.2 uc009miw.3 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Protein modification; protein ubiquitination. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. The C-terminus of APC10 binds to CDC27/APC3 (By similarity). Interacts with PIWIL1; interaction only takes place when PIWIL1 binds piRNA (PubMed:23328397). Interacts with FBXO43; the interaction is direct. Belongs to the APC10 family. protein binding anaphase-promoting complex cytoplasm cell cycle protein ubiquitination anaphase-promoting complex-dependent catabolic process cell division protein K11-linked ubiquitination uc009miw.1 uc009miw.2 uc009miw.3 
ENSMUST00000210823.2 Gm45339 ENSMUST00000210823.2 Gm45339 (from geneSymbol) ENSMUST00000210823.1 uc291wnr.1 uc291wnr.2 uc291wnr.1 uc291wnr.2 
ENSMUST00000210825.2 Gm45683 ENSMUST00000210825.2 Gm45683 (from geneSymbol) ENSMUST00000210825.1 uc291wpe.1 uc291wpe.2 uc291wpe.1 uc291wpe.2 
ENSMUST00000210843.2 6430710M23Rik ENSMUST00000210843.2 6430710M23Rik (from geneSymbol) AK018303 ENSMUST00000210843.1 uc291yyd.1 uc291yyd.2 uc291yyd.1 uc291yyd.2 
ENSMUST00000210850.2 Gm45341 ENSMUST00000210850.2 Gm45341 (from geneSymbol) AK006131 ENSMUST00000210850.1 uc291zwa.1 uc291zwa.2 uc291zwa.1 uc291zwa.2 
ENSMUST00000210852.2 Gm45265 ENSMUST00000210852.2 Gm45265 (from geneSymbol) ENSMUST00000210852.1 uc291zxz.1 uc291zxz.2 uc291zxz.1 uc291zxz.2 
ENSMUST00000210861.2 Slc6a21 ENSMUST00000210861.2 solute carrier family 6 member 21 (from RefSeq NM_001033176.2) A0A1B0GSD2 A0A1B0GSD2_MOUSE ENSMUST00000210861.1 NM_001033176 Slc6a21 uc009gum.1 uc009gum.2 uc009gum.3 Membrane ; Multi- pass membrane protein Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. neurotransmitter:sodium symporter activity plasma membrane neurotransmitter transport symporter activity membrane integral component of membrane transmembrane transport uc009gum.1 uc009gum.2 uc009gum.3 
ENSMUST00000210877.3 Gm3912 ENSMUST00000210877.3 Gm3912 (from geneSymbol) AF011425 ENSMUST00000210877.1 ENSMUST00000210877.2 uc291lfb.1 uc291lfb.2 uc291lfb.3 uc291lfb.1 uc291lfb.2 uc291lfb.3 
ENSMUST00000210896.2 Gm29682 ENSMUST00000210896.2 predicted gene, 29682 (from RefSeq NR_131138.1) ENSMUST00000210896.1 NR_131138 uc057amq.1 uc057amq.2 uc057amq.1 uc057amq.2 
ENSMUST00000210903.2 Gm45342 ENSMUST00000210903.2 Gm45342 (from geneSymbol) ENSMUST00000210903.1 LF298557 uc291yxl.1 uc291yxl.2 uc291yxl.1 uc291yxl.2 
ENSMUST00000210925.2 Gm4553 ENSMUST00000210925.2 predicted gene 4553 (from RefSeq NM_001378683.1) A0A1B0GSA9 A0A1B0GSA9_MOUSE ENSMUST00000210925.1 Gm4553 NM_001378683 uc291xhl.1 uc291xhl.2 molecular_function cellular_component biological_process keratin filament uc291xhl.1 uc291xhl.2 
ENSMUST00000210926.2 Gm45652 ENSMUST00000210926.2 Gm45652 (from geneSymbol) ENSMUST00000210926.1 uc291zdk.1 uc291zdk.2 uc291zdk.1 uc291zdk.2 
ENSMUST00000210935.2 Gm19872 ENSMUST00000210935.2 Gm19872 (from geneSymbol) AK137304 ENSMUST00000210935.1 uc292bvi.1 uc292bvi.2 uc292bvi.1 uc292bvi.2 
ENSMUST00000210940.2 Gm45819 ENSMUST00000210940.2 Gm45819 (from geneSymbol) ENSMUST00000210940.1 uc291ukp.1 uc291ukp.2 uc291ukp.1 uc291ukp.2 
ENSMUST00000210942.2 Gm45328 ENSMUST00000210942.2 Gm45328 (from geneSymbol) AK029634 ENSMUST00000210942.1 uc291wql.1 uc291wql.2 uc291wql.1 uc291wql.2 
ENSMUST00000210943.2 4933430A20Rik ENSMUST00000210943.2 4933430A20Rik (from geneSymbol) AK016987 ENSMUST00000210943.1 uc291zjb.1 uc291zjb.2 uc291zjb.1 uc291zjb.2 
ENSMUST00000210952.2 ENSMUSG00000121773 ENSMUST00000210952.2 ENSMUSG00000121773 (from geneSymbol) AJ279846 ENSMUST00000210952.1 uc291lpr.1 uc291lpr.2 uc291lpr.1 uc291lpr.2 
ENSMUST00000210964.2 Gm45554 ENSMUST00000210964.2 Gm45554 (from geneSymbol) ENSMUST00000210964.1 uc291zww.1 uc291zww.2 uc291zww.1 uc291zww.2 
ENSMUST00000210973.3 Or13a24 ENSMUST00000210973.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRT5) ENSMUST00000210973.1 ENSMUST00000210973.2 Olfr538 Or13a24 Q7TRT5 Q7TRT5_MOUSE uc291wvg.1 uc291wvg.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291wvg.1 uc291wvg.2 
ENSMUST00000210977.2 1190028D05Rik ENSMUST00000210977.2 RIKEN cDNA 1190028D05 gene (from RefSeq NR_151738.1) ENSMUST00000210977.1 NR_151738 uc009lry.1 uc009lry.2 uc009lry.1 uc009lry.2 
ENSMUST00000210981.2 Gm45576 ENSMUST00000210981.2 Gm45576 (from geneSymbol) ENSMUST00000210981.1 uc291zuf.1 uc291zuf.2 uc291zuf.1 uc291zuf.2 
ENSMUST00000210999.2 Sae1 ENSMUST00000210999.2 SUMO1 activating enzyme subunit 1, transcript variant 2 (from RefSeq NM_001285891.1) Aos1 ENSMUST00000210999.1 NM_001285891 Q3TRG9 Q3TWJ0 Q9CSW9 Q9R1T2 SAE1_MOUSE Sua1 Ubl1a1 Uble1a uc009fhp.1 uc009fhp.2 uc009fhp.3 uc009fhp.4 The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity). Protein modification; protein sumoylation. Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I (By similarity). Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9R1T2-1; Sequence=Displayed; Name=2; IsoId=Q9R1T2-2; Sequence=VSP_022004; Broadly expressed, with highest levels in testis. Belongs to the ubiquitin-activating E1 family. nucleus cytoplasm cellular protein modification process protein C-terminus binding small protein activating enzyme activity ligase activity protein sumoylation SUMO activating enzyme activity SUMO activating enzyme complex protein modification by small protein conjugation ATP-dependent protein binding small protein activating enzyme binding protein heterodimerization activity uc009fhp.1 uc009fhp.2 uc009fhp.3 uc009fhp.4 
ENSMUST00000211017.3 Gm45271 ENSMUST00000211017.3 Gm45271 (from geneSymbol) ENSMUST00000211017.1 ENSMUST00000211017.2 uc291ymk.1 uc291ymk.2 uc291ymk.3 uc291ymk.1 uc291ymk.2 uc291ymk.3 
ENSMUST00000211023.2 Gm45261 ENSMUST00000211023.2 Gm45261 (from geneSymbol) A0A1B0GSP6 A0A1B0GSP6_MOUSE ENSMUST00000211023.1 Gm45261 uc287jqu.1 uc287jqu.2 uc287jqu.1 uc287jqu.2 
ENSMUST00000211028.2 Gm45267 ENSMUST00000211028.2 Gm45267 (from geneSymbol) AK040272 ENSMUST00000211028.1 uc009lib.1 uc009lib.2 uc009lib.1 uc009lib.2 
ENSMUST00000211031.3 Or13a27 ENSMUST00000211031.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGL4) A0A1B0GRK3 ENSMUST00000211031.1 ENSMUST00000211031.2 Olfr60 Or13a27 Q8VGL4 Q8VGL4_MOUSE uc291wud.1 uc291wud.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291wud.1 uc291wud.2 
ENSMUST00000211035.2 ENSMUSG00000121393 ENSMUST00000211035.2 ENSMUSG00000121393 (from geneSymbol) ENSMUST00000211035.1 uc289qqz.1 uc289qqz.2 uc289qqz.1 uc289qqz.2 
ENSMUST00000211039.2 Gm45487 ENSMUST00000211039.2 Gm45487 (from geneSymbol) ENSMUST00000211039.1 uc291pzr.1 uc291pzr.2 uc291pzr.1 uc291pzr.2 
ENSMUST00000211048.2 Gm45289 ENSMUST00000211048.2 Gm45289 (from geneSymbol) ENSMUST00000211048.1 uc292caa.1 uc292caa.2 uc292caa.1 uc292caa.2 
ENSMUST00000211052.2 Gm45527 ENSMUST00000211052.2 Gm45527 (from geneSymbol) ENSMUST00000211052.1 uc291tno.1 uc291tno.2 uc291tno.1 uc291tno.2 
ENSMUST00000211053.2 Gm45546 ENSMUST00000211053.2 Gm45546 (from geneSymbol) AK029445 ENSMUST00000211053.1 uc292aqv.1 uc292aqv.2 uc292aqv.1 uc292aqv.2 
ENSMUST00000211054.2 Gm45799 ENSMUST00000211054.2 Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. (from UniProt Q9WV96) AK166190 ENSMUST00000211054.1 Fxc1 Q545D2 Q9DCB5 Q9WV96 T10B_MOUSE Tim9b Timm10b Timm9b uc291tzy.1 uc291tzy.2 Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. Component of the TIM22 complex, which core is composed of TIMM22, associated with TIMM10 (TIMM10A and/or TIMM10B), TIMM9, AGK and TIMM29. Mitochondrion inner membrane ; Peripheral membrane protein The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane. Belongs to the small Tim family. mitochondrion mitochondrial inner membrane protein transport membrane mitochondrial intermembrane space protein transporter complex mitochondrial inner membrane protein insertion complex metal ion binding uc291tzy.1 uc291tzy.2 
ENSMUST00000211062.3 4933439N14Rik ENSMUST00000211062.3 4933439N14Rik (from geneSymbol) AK019859 ENSMUST00000211062.1 ENSMUST00000211062.2 uc291yfu.1 uc291yfu.2 uc291yfu.3 uc291yfu.1 uc291yfu.2 uc291yfu.3 
ENSMUST00000211063.2 Gm45378 ENSMUST00000211063.2 Gm45378 (from geneSymbol) AK042148 ENSMUST00000211063.1 uc291une.1 uc291une.2 uc291une.1 uc291une.2 
ENSMUST00000211070.3 Gm10578 ENSMUST00000211070.3 predicted gene 10578 (from RefSeq NR_045885.1) ENSMUST00000211070.1 ENSMUST00000211070.2 NR_045885 uc029wpe.1 uc029wpe.2 uc029wpe.3 uc029wpe.1 uc029wpe.2 uc029wpe.3 
ENSMUST00000211073.2 Smim39 ENSMUST00000211073.2 small integral membrane protein 39 (from RefSeq NM_001395420.1) A0A1B0GST8 A0A1B0GST8_MOUSE ENSMUST00000211073.1 Gm55978 NM_001395420 Smim39 uc287hfb.1 uc287hfb.2 membrane integral component of membrane uc287hfb.1 uc287hfb.2 
ENSMUST00000211080.2 Gm45408 ENSMUST00000211080.2 Gm45408 (from geneSymbol) ENSMUST00000211080.1 uc291ymu.1 uc291ymu.2 uc291ymu.1 uc291ymu.2 
ENSMUST00000211086.2 Gm45311 ENSMUST00000211086.2 Gm45311 (from geneSymbol) ENSMUST00000211086.1 uc291qaj.1 uc291qaj.2 uc291qaj.1 uc291qaj.2 
ENSMUST00000211088.2 Pvrig ENSMUST00000211088.2 poliovirus receptor related immunoglobulin domain containing (from RefSeq NM_001378438.1) A0A1B0GS01 A0A1B0GS01_MOUSE ENSMUST00000211088.1 NM_001378438 Pvrig uc291bcm.1 uc291bcm.2 protein binding plasma membrane membrane integral component of membrane phosphatase binding signaling receptor activity negative regulation of T cell receptor signaling pathway uc291bcm.1 uc291bcm.2 
ENSMUST00000211093.3 Or12j4 ENSMUST00000211093.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRT7) ENSMUST00000211093.1 ENSMUST00000211093.2 Olfr533 Or12j4 Q7TRT7 Q7TRT7_MOUSE uc009khs.1 uc009khs.2 uc009khs.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009khs.1 uc009khs.2 uc009khs.3 
ENSMUST00000211096.2 Gm33543 ENSMUST00000211096.2 predicted gene, 33543, transcript variant 1 (from RefSeq NR_169124.1) ENSMUST00000211096.1 NR_169124 uc287uir.1 uc287uir.2 uc287uir.1 uc287uir.2 
ENSMUST00000211101.3 Gm45388 ENSMUST00000211101.3 Gm45388 (from geneSymbol) ENSMUST00000211101.1 ENSMUST00000211101.2 uc291zwo.1 uc291zwo.2 uc291zwo.3 uc291zwo.1 uc291zwo.2 uc291zwo.3 
ENSMUST00000211109.2 Zfp791 ENSMUST00000211109.2 zinc finger protein 791, transcript variant 1 (from RefSeq NM_001037745.2) EG244556 ENSMUST00000211109.1 NM_001037745 Q497V9 Q497V9_MOUSE Zfp791 uc009mpl.1 uc009mpl.2 uc009mpl.3 molecular_function nucleic acid binding nucleus regulation of transcription, DNA-templated cellular response to DNA damage stimulus metal ion binding uc009mpl.1 uc009mpl.2 uc009mpl.3 
ENSMUST00000211111.2 Gm45272 ENSMUST00000211111.2 Gm45272 (from geneSymbol) AK135830 ENSMUST00000211111.1 uc009ixc.1 uc009ixc.2 uc009ixc.3 uc009ixc.1 uc009ixc.2 uc009ixc.3 
ENSMUST00000211115.2 Casp3 ENSMUST00000211115.2 caspase 3, transcript variant 2 (from RefSeq NM_009810.3) CASP3_MOUSE Cpp32 ENSMUST00000211115.1 NM_009810 O08668 P70677 Q8CHV5 Q9QWI4 uc009lql.1 uc009lql.2 uc009lql.3 uc009lql.4 This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this gene belongs to a subgroup of cysteinyl aspartate-specific proteases that are activated by initiator caspases and that perform the proteolytic cleavage of apoptotic target proteins. Mice defective for this gene exhibit a variety of phenotypes including reduced neuronal apoptosis resulting in hyperplasias, hearing loss, attenuated osteogenic differentiation of bone marrow stromal stem cells, and pre- and post-natal lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:8934524, PubMed:16469926). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:8934524, PubMed:16469926). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:12124386). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:25231987, PubMed:33725486). Reaction=Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.; EC=3.4.22.56; Evidence= Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce. P70677; P42859: Htt; NbExp=2; IntAct=EBI-1790419, EBI-5327353; P70677; P11103: Parp1; NbExp=3; IntAct=EBI-1790419, EBI-642213; P70677; P62270: Rps18; NbExp=5; IntAct=EBI-1790419, EBI-352460; P70677; Q96EK4: THAP11; Xeno; NbExp=2; IntAct=EBI-1790419, EBI-1790529; Cytoplasm Highest expression in spleen, lung, liver, kidney and heart (PubMed:9038361). Lower expression in brain, skeletal muscle and testis (PubMed:9038361). Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa. S-nitrosylated on its catalytic site cysteine in unstimulated cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol. Lethality; the majority of mice on the 129/Svj background die in utero or within weeks of birth because of many extra cells within the brains of these animals (PubMed:8934524). Defects are caused by impaired apoptosis (PubMed:8934524). Mice lacking Casp3 on the C57BL/6J background are viable (PubMed:16469926). Mice lacking Casp3 and Casp7 on the C57BL/6J background die immediately after birth because of defective heart development (PubMed:16469926). This suggests that Casp7 can partially rescue Casp3 in certain conditions (PubMed:16469926). Belongs to the peptidase C14A family. luteolysis response to hypoxia B cell homeostasis protease binding aspartic-type endopeptidase activity cysteine-type endopeptidase activity cyclin-dependent protein serine/threonine kinase inhibitor activity death receptor binding protein binding nucleus cytoplasm cytosol proteolysis apoptotic process cellular response to DNA damage stimulus axonal fasciculation heart development sensory perception of sound learning or memory peptidase activity cysteine-type peptidase activity intrinsic apoptotic signaling pathway in response to osmotic stress response to UV response to wounding response to glucose response to organic substance response to metal ion response to X-ray response to organic cyclic compound phospholipase A2 activator activity protein processing hydrolase activity hippocampus development neuron differentiation keratinocyte differentiation erythrocyte differentiation negative regulation of B cell proliferation death-inducing signaling complex regulation of protein stability response to cobalt ion response to estradiol response to lipopolysaccharide glial cell apoptotic process response to nicotine intracellular signal transduction wound healing response to drug response to hydrogen peroxide neuronal cell body T cell homeostasis positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of catalytic activity response to amino acid positive regulation of neuron apoptotic process macromolecular complex binding membrane raft cell fate commitment negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell cycle negative regulation of activated T cell proliferation response to antibiotic neurotrophin TRK receptor signaling pathway striated muscle cell differentiation response to glucocorticoid neuron apoptotic process anterior neural tube closure intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to organic substance cellular response to organic cyclic compound leukocyte apoptotic process cellular response to staurosporine cysteine-type endopeptidase activity involved in apoptotic process execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic signaling pathway cysteine-type endopeptidase activity involved in execution phase of apoptosis positive regulation of beta-amyloid formation uc009lql.1 uc009lql.2 uc009lql.3 uc009lql.4 
ENSMUST00000211116.2 Fam236c ENSMUST00000211116.2 family with sequence similarity 236, member C (from RefSeq NR_045422.1) 1700018G05Rik A0A1B0GSI2 A0A1B0GSI2_MOUSE ENSMUST00000211116.1 Fam236c NR_045422 uc292pvm.1 uc292pvm.2 uc292pvm.1 uc292pvm.2 
ENSMUST00000211118.2 Gm45334 ENSMUST00000211118.2 Gm45334 (from geneSymbol) ENSMUST00000211118.1 uc292cav.1 uc292cav.2 uc292cav.1 uc292cav.2 
ENSMUST00000211122.2 Gm45307 ENSMUST00000211122.2 Gm45307 (from geneSymbol) ENSMUST00000211122.1 uc291zag.1 uc291zag.2 uc291zag.1 uc291zag.2 
ENSMUST00000211129.2 Gm45717 ENSMUST00000211129.2 Belongs to the CD225/Dispanin family. (from UniProt A0A1B0GT68) A0A1B0GT68 A0A1B0GT68_MOUSE BC002102 ENSMUST00000211129.1 Gm45717 uc291wyc.1 uc291wyc.2 Belongs to the CD225/Dispanin family. plasma membrane membrane integral component of membrane response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication negative regulation of viral entry into host cell defense response to virus type I interferon signaling pathway uc291wyc.1 uc291wyc.2 
ENSMUST00000211137.2 Gm45570 ENSMUST00000211137.2 Gm45570 (from geneSymbol) ENSMUST00000211137.1 uc291yxb.1 uc291yxb.2 uc291yxb.1 uc291yxb.2 
ENSMUST00000211142.2 Gm6249 ENSMUST00000211142.2 predicted gene 6249 (from RefSeq NR_046021.1) ENSMUST00000211142.1 NR_046021 uc029wpd.1 uc029wpd.2 uc029wpd.1 uc029wpd.2 
ENSMUST00000211143.2 Gm45607 ENSMUST00000211143.2 Gm45607 (from geneSymbol) ENSMUST00000211143.1 uc291zss.1 uc291zss.2 uc291zss.1 uc291zss.2 
ENSMUST00000211145.2 Erc2 ENSMUST00000211145.2 ELKS/RAB6-interacting/CAST family member 2, transcript variant 5 (from RefSeq NM_001404937.1) Cast1 D14Ertd171e ENSMUST00000211145.1 ERC2_MOUSE Kiaa0378 NM_001404937 Q6PH08 Q80U20 Q8CCP1 uc288rtk.1 uc288rtk.2 Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. Interacts with BSN, ERC1, PPFIA1, PPFIA2, PPFIA3 and PPFIA4. Interacts through its C-terminus with the PDZ domain of RIMS1. Part of a complex consisting of ERC2, RIMS1 and UNC13A. Cytoplasm Synapse Presynaptic active zone Cytoplasm, cytoskeleton Note=Localized to the active zone of presynaptic density. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6PH08-1; Sequence=Displayed; Name=2; IsoId=Q6PH08-2; Sequence=VSP_012306, VSP_011467; Name=3; IsoId=Q6PH08-3; Sequence=VSP_011469, VSP_011470; Name=4; IsoId=Q6PH08-4; Sequence=VSP_011466, VSP_011468, VSP_011471; Expressed throughout the central nervous system, including hippocampus, cortex, cerebellum and olfactory bulb. [Isoform 4]: Due to intron retention. Sequence=BAC65547.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein binding cytoplasm Golgi-associated vesicle cytoskeleton postsynaptic density membrane synaptic vesicle priming cell junction PDZ domain binding growth cone macromolecular complex presynaptic membrane neuron projection neuronal cell body terminal bouton macromolecular complex binding synapse presynaptic active zone maintenance of presynaptic active zone structure presynaptic active zone cytoplasmic component structural constituent of presynaptic active zone glutamatergic synapse GABA-ergic synapse uc288rtk.1 uc288rtk.2 
ENSMUST00000211147.2 Gm45435 ENSMUST00000211147.2 Gm45435 (from geneSymbol) ENSMUST00000211147.1 uc292bgs.1 uc292bgs.2 uc292bgs.1 uc292bgs.2 
ENSMUST00000211157.2 Gm45237 ENSMUST00000211157.2 Gm45237 (from geneSymbol) AK145052 ENSMUST00000211157.1 uc291ywc.1 uc291ywc.2 uc291ywc.1 uc291ywc.2 
ENSMUST00000211162.2 Gm45650 ENSMUST00000211162.2 Gm45650 (from geneSymbol) ENSMUST00000211162.1 NR_190376 uc292aco.1 uc292aco.2 uc292aco.1 uc292aco.2 
ENSMUST00000211163.2 Gm45389 ENSMUST00000211163.2 Gm45389 (from geneSymbol) AK043520 ENSMUST00000211163.1 uc291zwl.1 uc291zwl.2 uc291zwl.1 uc291zwl.2 
ENSMUST00000211170.2 Gm45846 ENSMUST00000211170.2 Gm45846 (from geneSymbol) AK140221 ENSMUST00000211170.1 uc291vfh.1 uc291vfh.2 uc291vfh.1 uc291vfh.2 
ENSMUST00000211177.2 Gm45290 ENSMUST00000211177.2 Gm45290 (from geneSymbol) ENSMUST00000211177.1 uc292cab.1 uc292cab.2 uc292cab.1 uc292cab.2 
ENSMUST00000211181.2 4930544L04Rik ENSMUST00000211181.2 4930544L04Rik (from geneSymbol) AK133210 ENSMUST00000211181.1 uc009keb.1 uc009keb.2 uc009keb.3 uc009keb.1 uc009keb.2 uc009keb.3 
ENSMUST00000211193.2 Gm45324 ENSMUST00000211193.2 Gm45324 (from geneSymbol) ENSMUST00000211193.1 uc291zvz.1 uc291zvz.2 uc291zvz.1 uc291zvz.2 
ENSMUST00000211202.2 Gm45675 ENSMUST00000211202.2 Gm45675 (from geneSymbol) ENSMUST00000211202.1 uc291ymv.1 uc291ymv.2 uc291ymv.1 uc291ymv.2 
ENSMUST00000211209.3 0610005C13Rik ENSMUST00000211209.3 0610005C13Rik (from geneSymbol) AK002217 ENSMUST00000211209.1 ENSMUST00000211209.2 uc291pvi.1 uc291pvi.2 uc291pvi.3 uc291pvi.1 uc291pvi.2 uc291pvi.3 
ENSMUST00000211214.2 Ruvbl2 ENSMUST00000211214.2 Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (By similarity). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (By similarity). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP- dependent nucleosome sliding (By similarity). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (By similarity). May also inhibit the transcriptional activity of ATF2 (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (By similarity). May play a role in regulating the composition of the U5 snRNP complex (By similarity). (from UniProt Q9WTM5) BC072585 ENSMUST00000211214.1 Q9WTM5 RUVB2_MOUSE uc291ptd.1 uc291ptd.2 Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (By similarity). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (By similarity). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP- dependent nucleosome sliding (By similarity). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (By similarity). May also inhibit the transcriptional activity of ATF2 (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (By similarity). May play a role in regulating the composition of the U5 snRNP complex (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Forms homohexameric rings (Probable). Can form a dodecamer with RUVBL1 made of two stacked hexameric rings; however, even though RUVBL1 and RUVBL2 are present in equimolar ratio, the oligomeric status of each hexamer is not known. Oligomerization may regulate binding to nucleic acids and conversely, binding to nucleic acids may affect the dodecameric assembly. Interaction of the complex with DHX34 results in conformational changes of the N-terminus of the RUVBL2 subunits, resulting in loss of nucleotide binding ability and ATP hydrolysis of the complex (By similarity). Interacts with the transcriptional activation domain of MYC. Interacts with ATF2. Component of the RNA polymerase II holoenzyme complex. May also act to bridge the LEF1/TCF1- CTNNB1 complex and TBP. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. RUVBL2 interacts with EP400. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Interacts with NPAT. Component of the chromatin-remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with IGHMBP2. Interacts with TELO2. Interacts with HINT1. Component of a SWR1-like complex. Component of the R2TP complex composed at least of RUVBL1, RUVBL2, RPAP3 and PIHD1. Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92. Interacts with ITFG1. Interacts with ZMYND10. Interacts with WAC; WAC positively regulates MTOR activity by promoting the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex which leads to the dimerization of the mTORC1 complex and its subsequent activation. Forms a complex with APPL1 and APPL2 (By similarity). Interacts with ZNHIT2 (via HIT-type zinc finger) in the presence of ATP or ADP; shows a stronger interaction in the presence of ADP (By similarity). The RUVBL1/RUVBL2 complex interacts with ZNHIT1 (via HIT-type zinc finger), ZNHIT3 (via HIT-type zinc finger), ZNHIT6 (via HIT-type zinc finger) and DDX59/ZNHIT5 (via HIT-type zinc finger) in the presence of ADP (By similarity). Interacts with NOPCHAP1; the interaction is direct and disrupted upon ATP binding (By similarity). Interacts with SMG1 (By similarity). Q9WTM5; P60122: Ruvbl1; NbExp=3; IntAct=EBI-2549911, EBI-1634999; Nucleus matrix Nucleus, nucleoplasm Cytoplasm Membrane Dynein axonemal particle Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol. Although it is also present in the cytoplasm and associated with the cell membranes. Belongs to the RuvB family. nucleotide binding box C/D snoRNP assembly Swr1 complex RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding TFIID-class transcription factor binding DNA helicase activity transcription corepressor activity helicase activity protein binding ATP binding nucleus nucleoplasm nuclear euchromatin cytoplasm centrosome cytosol DNA repair DNA recombination chromatin organization chromatin remodeling regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus beta-catenin binding histone acetylation hydrolase activity ATPase activity TBP-class protein binding Ino80 complex chromatin DNA binding DNA duplex unwinding cellular response to UV positive regulation of histone acetylation NuA4 histone acetyltransferase complex identical protein binding protein homodimerization activity 5'-3' DNA helicase activity ADP binding histone H4 acetylation histone H2A acetylation positive regulation of transcription from RNA polymerase II promoter ATPase binding establishment of protein localization to chromatin MLL1 complex cellular response to estradiol stimulus transcriptional activation by promoter-enhancer looping negative regulation of estrogen receptor binding negative regulation of canonical Wnt signaling pathway R2TP complex negative regulation of nucleic acid-templated transcription ribonucleoprotein complex uc291ptd.1 uc291ptd.2 
ENSMUST00000211219.2 Gm15839 ENSMUST00000211219.2 Gm15839 (from geneSymbol) ENSMUST00000211219.1 uc289fco.1 uc289fco.2 uc289fco.1 uc289fco.2 
ENSMUST00000211227.2 Plekha4 ENSMUST00000211227.2 Plekha4 (from geneSymbol) A0A1B0GSM9 A0A1B0GSM9_MOUSE BC021387 ENSMUST00000211227.1 Plekha4 uc009gvv.1 uc009gvv.2 uc009gvv.1 uc009gvv.2 
ENSMUST00000211232.2 Gm45292 ENSMUST00000211232.2 Gm45292 (from geneSymbol) ENSMUST00000211232.1 uc292bzy.1 uc292bzy.2 uc292bzy.1 uc292bzy.2 
ENSMUST00000211237.3 Gm45241 ENSMUST00000211237.3 Gm45241 (from geneSymbol) ENSMUST00000211237.1 ENSMUST00000211237.2 uc291woc.1 uc291woc.2 uc291woc.3 uc291woc.1 uc291woc.2 uc291woc.3 
ENSMUST00000211239.2 Gm45303 ENSMUST00000211239.2 Gm45303 (from geneSymbol) ENSMUST00000211239.1 uc291zej.1 uc291zej.2 uc291zej.1 uc291zej.2 
ENSMUST00000211245.2 Gm13539 ENSMUST00000211245.2 Secreted (from UniProt A0A1B0GSM6) A0A1B0GSM6 A0A1B0GSM6_MOUSE AK076911 ENSMUST00000211245.1 Gm13539 uc289uap.1 uc289uap.2 Secreted Belongs to the calycin superfamily. Lipocalin family. small molecule binding uc289uap.1 uc289uap.2 
ENSMUST00000211251.3 Gm6145 ENSMUST00000211251.3 Gm6145 (from geneSymbol) AK045385 ENSMUST00000211251.1 ENSMUST00000211251.2 uc288wim.1 uc288wim.2 uc288wim.3 uc288wim.1 uc288wim.2 uc288wim.3 
ENSMUST00000211255.2 Gm45889 ENSMUST00000211255.2 Gm45889 (from geneSymbol) ENSMUST00000211255.1 uc291xhx.1 uc291xhx.2 uc291xhx.1 uc291xhx.2 
ENSMUST00000211257.2 ENSMUSG00000121386 ENSMUST00000211257.2 ENSMUSG00000121386 (from geneSymbol) ENSMUST00000211257.1 uc291lgm.1 uc291lgm.2 uc291lgm.1 uc291lgm.2 
ENSMUST00000211264.2 1700020G03Rik ENSMUST00000211264.2 1700020G03Rik (from geneSymbol) AK006158 ENSMUST00000211264.1 uc292aos.1 uc292aos.2 uc292aos.1 uc292aos.2 
ENSMUST00000211267.3 Gm45462 ENSMUST00000211267.3 Gm45462 (from geneSymbol) ENSMUST00000211267.1 ENSMUST00000211267.2 uc292aeo.1 uc292aeo.2 uc292aeo.3 uc292aeo.1 uc292aeo.2 uc292aeo.3 
ENSMUST00000211274.3 Gm45370 ENSMUST00000211274.3 Gm45370 (from geneSymbol) ENSMUST00000211274.1 ENSMUST00000211274.2 uc291zaz.1 uc291zaz.2 uc291zaz.3 uc291zaz.1 uc291zaz.2 uc291zaz.3 
ENSMUST00000211278.2 Gm7706 ENSMUST00000211278.2 Gm7706 (from geneSymbol) ENSMUST00000211278.1 uc291ymi.1 uc291ymi.2 uc291ymi.1 uc291ymi.2 
ENSMUST00000211283.2 Caly ENSMUST00000211283.2 calcyon neuron-specific vesicular protein, transcript variant A (from RefSeq NM_026769.5) CALY_MOUSE Drd1ip ENSMUST00000211283.1 NM_026769 Q9D1K9 Q9DCA7 uc009kgs.1 uc009kgs.2 uc009kgs.3 uc009kgs.4 Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. Interacts with CLTA. Cytoplasmic vesicle membrane ; Single-pass membrane protein Cell membrane ; Single-pass membrane protein Most abundant in brain. Also expressed in testis and ovary and, at much lower levels, in kidney and heart. Mice display impaired clathrin assembly and clathrin-mediated endocytosis. Transgenic mice with up-regulated forebrain expression of Caly display a range of abnormal behaviors including spontaneous hyperactivity, reduced anxiety and/or impaired harm avoidance. Belongs to the NSG family. The human ortholog was originally thought to interact with the D1 dopamine receptor (DRD1) and to play a role in potentiating calcium ion-dependent signaling but this work was later retracted. endosome plasma membrane integral component of plasma membrane endocytosis dopamine receptor signaling pathway membrane integral component of membrane endosomal transport cytoplasmic vesicle membrane cytoplasmic vesicle clathrin light chain binding macromolecular complex binding positive regulation of endocytosis clathrin coat assembly postsynaptic endocytic zone postsynaptic neurotransmitter receptor internalization glutamatergic synapse uc009kgs.1 uc009kgs.2 uc009kgs.3 uc009kgs.4 
ENSMUST00000211285.2 Gm35521 ENSMUST00000211285.2 Gm35521 (from geneSymbol) AK145215 ENSMUST00000211285.1 uc009luv.1 uc009luv.2 uc009luv.1 uc009luv.2 
ENSMUST00000211288.3 Ccdc196 ENSMUST00000211288.3 coiled-coil domain containing 196, transcript variant 1 (from RefSeq NM_001374218.1) A0A1B0GRJ3 A0A1B0GRJ3_MOUSE Ccdc196 ENSMUST00000211288.1 ENSMUST00000211288.2 Gm6657 NM_001374218 uc288hjj.1 uc288hjj.2 molecular_function cellular_component biological_process uc288hjj.1 uc288hjj.2 
ENSMUST00000211295.4 Gm45472 ENSMUST00000211295.4 Gm45472 (from geneSymbol) ENSMUST00000211295.1 ENSMUST00000211295.2 ENSMUST00000211295.3 uc292cbj.1 uc292cbj.2 uc292cbj.3 uc292cbj.4 uc292cbj.1 uc292cbj.2 uc292cbj.3 uc292cbj.4 
ENSMUST00000211297.3 Gm8110 ENSMUST00000211297.3 Gm8110 (from geneSymbol) ENSMUST00000211297.1 ENSMUST00000211297.2 uc291zdf.1 uc291zdf.2 uc291zdf.3 uc291zdf.1 uc291zdf.2 uc291zdf.3 
ENSMUST00000211300.2 Tmem238l ENSMUST00000211300.2 transmembrane protein 238 like, transcript variant 1 (from RefSeq NM_001388430.1) 9130409J20Rik A0A1B0GS74 A0A1B0GS74_MOUSE ENSMUST00000211300.1 NM_001388430 Tmem238l uc287zah.1 uc287zah.2 molecular_function cellular_component biological_process membrane integral component of membrane uc287zah.1 uc287zah.2 
ENSMUST00000211306.2 Gm45676 ENSMUST00000211306.2 Gm45676 (from geneSymbol) ENSMUST00000211306.1 uc291ymt.1 uc291ymt.2 uc291ymt.1 uc291ymt.2 
ENSMUST00000211328.2 Gm45244 ENSMUST00000211328.2 Gm45244 (from geneSymbol) BC052545 ENSMUST00000211328.1 uc057cbx.1 uc057cbx.2 uc057cbx.1 uc057cbx.2 
ENSMUST00000211329.2 Or51t4 ENSMUST00000211329.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1B0GRW7) A0A1B0GRW7 A0A1B0GRW7_MOUSE BC127050 ENSMUST00000211329.1 Olfr574 Or51t4 uc291tom.1 uc291tom.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tom.1 uc291tom.2 
ENSMUST00000211331.2 Gm45410 ENSMUST00000211331.2 Gm45410 (from geneSymbol) DQ707088 ENSMUST00000211331.1 uc291yjo.1 uc291yjo.2 uc291yjo.1 uc291yjo.2 
ENSMUST00000211339.2 Gm45521 ENSMUST00000211339.2 predicted gene 45521 (from RefSeq NM_001371278.1) A0A1B0GRK0 A0A1B0GRK0_MOUSE ENSMUST00000211339.1 Gm45521 NM_001371278 uc288qrc.1 uc288qrc.2 uc288qrc.1 uc288qrc.2 
ENSMUST00000211342.2 Gm45355 ENSMUST00000211342.2 Gm45355 (from geneSymbol) ENSMUST00000211342.1 uc291uox.1 uc291uox.2 uc291uox.1 uc291uox.2 
ENSMUST00000211345.3 Or5p66 ENSMUST00000211345.3 Potential odorant receptor. (from UniProt Q8VFD2) ENSMUST00000211345.1 ENSMUST00000211345.2 Mor204-17 O5P66_MOUSE Olfr490 Or5p66 Q8VFD2 uc291ugo.1 uc291ugo.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ugo.1 uc291ugo.2 
ENSMUST00000211350.2 Krtap5-23 ENSMUST00000211350.2 predicted gene, 39115 (from RefSeq NM_001347556.1) A0A1B0GSH7 A0A1B0GSH7_MOUSE ENSMUST00000211350.1 Gm39115 NM_001347556 uc057lvy.1 uc057lvy.2 keratin filament uc057lvy.1 uc057lvy.2 
ENSMUST00000211351.3 Gm32786 ENSMUST00000211351.3 Gm32786 (from geneSymbol) ENSMUST00000211351.1 ENSMUST00000211351.2 uc291xhg.1 uc291xhg.2 uc291xhg.3 uc291xhg.1 uc291xhg.2 uc291xhg.3 
ENSMUST00000211352.2 Rcn3 ENSMUST00000211352.2 reticulocalbin 3, EF-hand calcium binding domain, transcript variant 2 (from RefSeq NM_001355045.1) D7Ertd671e ENSMUST00000211352.1 NM_001355045 Q58E50 Q8BH97 Q8R137 Q99K35 Q9CTD4 RCN3_MOUSE Rcn3 uc009gta.1 uc009gta.2 uc009gta.3 uc009gta.4 uc009gta.5 Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:26252542). Required for the proper biosynthesis and transport of pulmonary surfactant- associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (PubMed:26252542). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (PubMed:26252542). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (By similarity). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (By similarity). Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6. Endoplasmic reticulum lumen Highly expressed in lung and heart. Also detected in liver, spleen, kidney, skeletal muscle, intestine, stomach, and brain. During lung development the expression is detected from 15.5 dpc to P1 with a maximum at 17.5 dpc which corresponds to the stage of development of alveolar saccules. Degraded by PCSK6 and other endoproteases including FURIN and PCSK5. N-glycosylated. Homozygous knockout mice show neonatal lethality (PubMed:26252542). Normally delivered newborn mice exhibit normal gross morphology, early motor activity, and response to painful stimuli (PubMed:26252542). They quickly develop severe respiratory distress with gasping and cyanosis, and die within 20 to 60 minutes after birth (PubMed:26252542). Normally developed trachea and diaphragm structure as well as no obvious gross morphological or histological abnormalities in the heart, brain, or liver suggest that abnormal lung development is the primary cause for the neonatal lethality (PubMed:26252542). Mutant mice exhibit morphological abnormalities of the lungs, including atelectasis with collapse of the alveolar space and unexpanded intra- alveolar septae (PubMed:26252542). This is associated with an impaired maturation of type 2 alveolar epithelial cells which is probably due to their failure to properly produce pulmonary surfactant (PubMed:26252542). Belongs to the CREC family. calcium ion binding endoplasmic reticulum endoplasmic reticulum lumen protein secretion positive regulation of peptidase activity protein transport collagen biosynthetic process ERAD pathway surfactant homeostasis metal ion binding regulation of protein kinase B signaling phospholipid homeostasis lung epithelium development uc009gta.1 uc009gta.2 uc009gta.3 uc009gta.4 uc009gta.5 
ENSMUST00000211360.3 Gm6853 ENSMUST00000211360.3 Gm6853 (from geneSymbol) ENSMUST00000211360.1 ENSMUST00000211360.2 uc291zdq.1 uc291zdq.2 uc291zdq.3 uc291zdq.1 uc291zdq.2 uc291zdq.3 
ENSMUST00000211364.2 Gm45643 ENSMUST00000211364.2 Gm45643 (from geneSymbol) ENSMUST00000211364.1 uc292byf.1 uc292byf.2 uc292byf.1 uc292byf.2 
ENSMUST00000211368.2 Pde2a ENSMUST00000211368.2 phosphodiesterase 2A, cGMP-stimulated, transcript variant 2 (from RefSeq NM_001008548.5) ENSMUST00000211368.1 NM_001008548 Pde2a Q5PR72 Q5PR72_MOUSE uc009iop.1 uc009iop.2 uc009iop.3 uc009iop.4 uc009iop.5 Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ; Belongs to the cyclic nucleotide phosphodiesterase family. 3',5'-cyclic-nucleotide phosphodiesterase activity signal transduction phosphoric diester hydrolase activity hydrolase activity metal ion binding uc009iop.1 uc009iop.2 uc009iop.3 uc009iop.4 uc009iop.5 
ENSMUST00000211372.2 Urah ENSMUST00000211372.2 urate (5-hydroxyiso-) hydrolase, transcript variant 3 (from RefSeq NM_001359805.1) ENSMUST00000211372.1 HIUH_MOUSE NM_001359805 Q9CRB3 uc291wwe.1 uc291wwe.2 Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). Reaction=5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5- dihydro-1H-imidazole-5-carboxylate + H(+); Xref=Rhea:RHEA:23736, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18072, ChEBI:CHEBI:58639; EC=3.5.2.17; Evidence=; Purine metabolism; urate degradation; (S)-allantoin from urate: step 2/3. Homotetramer. Peroxisome HIU hydrolysis also occurs spontaneously, but more slowly. Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. mitochondrion peroxisome purine nucleobase metabolic process hydrolase activity urate catabolic process hydroxyisourate hydrolase activity uc291wwe.1 uc291wwe.2 
ENSMUST00000211374.2 Gm45524 ENSMUST00000211374.2 Gm45524 (from geneSymbol) AK131773 ENSMUST00000211374.1 uc291zjs.1 uc291zjs.2 uc291zjs.1 uc291zjs.2 
ENSMUST00000211381.2 B930018H19Rik ENSMUST00000211381.2 RIKEN cDNA B930018H19 gene (from RefSeq NR_040706.1) ENSMUST00000211381.1 NR_040706 uc029wsg.1 uc029wsg.2 uc029wsg.1 uc029wsg.2 
ENSMUST00000211382.4 Gm45670 ENSMUST00000211382.4 Gm45670 (from geneSymbol) AK041267 ENSMUST00000211382.1 ENSMUST00000211382.2 ENSMUST00000211382.3 uc009kdm.1 uc009kdm.2 uc009kdm.3 uc009kdm.4 uc009kdm.5 uc009kdm.1 uc009kdm.2 uc009kdm.3 uc009kdm.4 uc009kdm.5 
ENSMUST00000211384.2 Usp17le ENSMUST00000211384.2 ubiquitin specific peptidase 17-like E (from RefSeq NM_001256973.1) A0A1B0GS33 A0A1B0GS33_MOUSE ENSMUST00000211384.1 NM_001256973 Usp17le uc029wnn.1 uc029wnn.2 Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence= Belongs to the peptidase C19 family. proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity uc029wnn.1 uc029wnn.2 
ENSMUST00000211385.2 Gm45460 ENSMUST00000211385.2 Gm45460 (from geneSymbol) ENSMUST00000211385.1 uc292aem.1 uc292aem.2 uc292aem.1 uc292aem.2 
ENSMUST00000211391.2 Gm45693 ENSMUST00000211391.2 Gm45693 (from geneSymbol) ENSMUST00000211391.1 uc291zrj.1 uc291zrj.2 uc291zrj.1 uc291zrj.2 
ENSMUST00000211394.2 Gm45444 ENSMUST00000211394.2 Gm45444 (from geneSymbol) AK131672 ENSMUST00000211394.1 uc291pxv.1 uc291pxv.2 uc291pxv.1 uc291pxv.2 
ENSMUST00000211401.2 Gm19269 ENSMUST00000211401.2 Gm19269 (from geneSymbol) AK155491 ENSMUST00000211401.1 uc292abh.1 uc292abh.2 uc292abh.1 uc292abh.2 
ENSMUST00000211407.2 Gm45504 ENSMUST00000211407.2 Gm45504 (from geneSymbol) AK143776 ENSMUST00000211407.1 uc292bxm.1 uc292bxm.2 uc292bxm.1 uc292bxm.2 
ENSMUST00000211415.2 Gm45593 ENSMUST00000211415.2 Gm45593 (from geneSymbol) AK139792 ENSMUST00000211415.1 uc291lpw.1 uc291lpw.2 uc291lpw.1 uc291lpw.2 
ENSMUST00000211418.2 Gm45437 ENSMUST00000211418.2 Gm45437 (from geneSymbol) ENSMUST00000211418.1 uc291pvy.1 uc291pvy.2 uc291pvy.1 uc291pvy.2 
ENSMUST00000211421.3 Gm31105 ENSMUST00000211421.3 Gm31105 (from geneSymbol) ENSMUST00000211421.1 ENSMUST00000211421.2 uc292bhm.1 uc292bhm.2 uc292bhm.3 uc292bhm.1 uc292bhm.2 uc292bhm.3 
ENSMUST00000211426.2 Gm9860 ENSMUST00000211426.2 Gm9860 (from geneSymbol) ENSMUST00000211426.1 uc291qaa.1 uc291qaa.2 uc291qaa.1 uc291qaa.2 
ENSMUST00000211427.2 Gm45345 ENSMUST00000211427.2 Gm45345 (from geneSymbol) ENSMUST00000211427.1 uc292afz.1 uc292afz.2 uc292afz.1 uc292afz.2 
ENSMUST00000211429.2 Flt3l ENSMUST00000211429.2 Flt3l (from geneSymbol) A0A1B0GRC9 A0A1B0GRC9_MOUSE ENSMUST00000211429.1 Flt3l U04807 uc009gtp.1 uc009gtp.2 uc009gtp.3 uc009gtp.4 cytokine activity signal transduction membrane integral component of membrane uc009gtp.1 uc009gtp.2 uc009gtp.3 uc009gtp.4 
ENSMUST00000211430.3 Mir670hg ENSMUST00000211430.3 Mir670hg (from geneSymbol) AK089118 ENSMUST00000211430.1 ENSMUST00000211430.2 uc289yrh.1 uc289yrh.2 uc289yrh.3 uc289yrh.1 uc289yrh.2 uc289yrh.3 
ENSMUST00000211437.2 Gm45240 ENSMUST00000211437.2 Gm45240 (from geneSymbol) ENSMUST00000211437.1 uc291wnz.1 uc291wnz.2 uc291wnz.1 uc291wnz.2 
ENSMUST00000211443.2 1300002E11Rik ENSMUST00000211443.2 1300002E11Rik (from geneSymbol) ENSMUST00000211443.1 KY467471 uc289dpj.1 uc289dpj.2 uc289dpj.1 uc289dpj.2 
ENSMUST00000211447.3 Gm45745 ENSMUST00000211447.3 Gm45745 (from geneSymbol) AK040681 ENSMUST00000211447.1 ENSMUST00000211447.2 uc291yvk.1 uc291yvk.2 uc291yvk.3 uc291yvk.1 uc291yvk.2 uc291yvk.3 
ENSMUST00000211449.2 Gm45534 ENSMUST00000211449.2 Gm45534 (from geneSymbol) ENSMUST00000211449.1 uc292abf.1 uc292abf.2 uc292abf.1 uc292abf.2 
ENSMUST00000211460.2 Gm45338 ENSMUST00000211460.2 Gm45338 (from geneSymbol) AK144897 ENSMUST00000211460.1 uc007ytv.1 uc007ytv.2 uc007ytv.3 uc007ytv.1 uc007ytv.2 uc007ytv.3 
ENSMUST00000211463.3 Mtag2 ENSMUST00000211463.3 metastasis associated gene 2, transcript variant 2 (from RefSeq NR_015480.2) ENSMUST00000211463.1 ENSMUST00000211463.2 NR_015480 uc012fkj.1 uc012fkj.2 uc012fkj.3 uc012fkj.4 uc012fkj.1 uc012fkj.2 uc012fkj.3 uc012fkj.4 
ENSMUST00000211464.2 9330121K16Rik ENSMUST00000211464.2 9330121K16Rik (from geneSymbol) ENSMUST00000211464.1 uc291zyd.1 uc291zyd.2 uc291zyd.1 uc291zyd.2 
ENSMUST00000211466.2 Gm45714 ENSMUST00000211466.2 Gm45714 (from geneSymbol) DQ702122 ENSMUST00000211466.1 uc292bem.1 uc292bem.2 uc292bem.1 uc292bem.2 
ENSMUST00000211467.2 Gm9911 ENSMUST00000211467.2 Gm9911 (from geneSymbol) ENSMUST00000211467.1 uc291zdj.1 uc291zdj.2 uc291zdj.1 uc291zdj.2 
ENSMUST00000211468.2 Gm45501 ENSMUST00000211468.2 Gm45501 (from geneSymbol) ENSMUST00000211468.1 uc291wkd.1 uc291wkd.2 uc291wkd.1 uc291wkd.2 
ENSMUST00000211470.2 Gm45645 ENSMUST00000211470.2 Gm45645 (from geneSymbol) AK047806 ENSMUST00000211470.1 uc288rto.1 uc288rto.2 uc288rto.1 uc288rto.2 
ENSMUST00000211474.2 Gm45666 ENSMUST00000211474.2 Gm45666 (from geneSymbol) ENSMUST00000211474.1 uc292bzj.1 uc292bzj.2 uc292bzj.1 uc292bzj.2 
ENSMUST00000211481.2 AA386476 ENSMUST00000211481.2 AA386476 (from geneSymbol) AK083994 ENSMUST00000211481.1 uc009lrg.1 uc009lrg.2 uc009lrg.1 uc009lrg.2 
ENSMUST00000211483.2 Gm45601 ENSMUST00000211483.2 Gm45601 (from geneSymbol) ENSMUST00000211483.1 uc292bgd.1 uc292bgd.2 uc292bgd.1 uc292bgd.2 
ENSMUST00000211485.2 Gm45449 ENSMUST00000211485.2 Gm45449 (from geneSymbol) AK140365 ENSMUST00000211485.1 uc292bjk.1 uc292bjk.2 uc292bjk.1 uc292bjk.2 
ENSMUST00000211492.2 Gm45560 ENSMUST00000211492.2 Gm45560 (from geneSymbol) ENSMUST00000211492.1 uc291yfr.1 uc291yfr.2 uc291yfr.1 uc291yfr.2 
ENSMUST00000211507.2 Gm45638 ENSMUST00000211507.2 Gm45638 (from geneSymbol) ENSMUST00000211507.1 uc292bxu.1 uc292bxu.2 uc292bxu.1 uc292bxu.2 
ENSMUST00000211516.2 Gm45635 ENSMUST00000211516.2 Gm45635 (from geneSymbol) ENSMUST00000211516.1 uc292abu.1 uc292abu.2 uc292abu.1 uc292abu.2 
ENSMUST00000211520.2 Gm45885 ENSMUST00000211520.2 Gm45885 (from geneSymbol) AK053312 ENSMUST00000211520.1 uc291txz.1 uc291txz.2 uc291txz.1 uc291txz.2 
ENSMUST00000211524.2 Gm45597 ENSMUST00000211524.2 Gm45597 (from geneSymbol) AK077083 ENSMUST00000211524.1 uc291wnl.1 uc291wnl.2 uc291wnl.1 uc291wnl.2 
ENSMUST00000211528.2 Gm45309 ENSMUST00000211528.2 Gm45309 (from geneSymbol) ENSMUST00000211528.1 uc291qbn.1 uc291qbn.2 uc291qbn.1 uc291qbn.2 
ENSMUST00000211529.3 Gm15328 ENSMUST00000211529.3 Gm15328 (from geneSymbol) AK085921 ENSMUST00000211529.1 ENSMUST00000211529.2 uc289ofv.1 uc289ofv.2 uc289ofv.3 uc289ofv.1 uc289ofv.2 uc289ofv.3 
ENSMUST00000211532.2 Gm45632 ENSMUST00000211532.2 Gm45632 (from geneSymbol) AK051491 ENSMUST00000211532.1 uc291tzb.1 uc291tzb.2 uc291tzb.1 uc291tzb.2 
ENSMUST00000211533.3 A030001D20Rik ENSMUST00000211533.3 RIKEN cDNA A030001D20 gene (from RefSeq NR_152217.1) ENSMUST00000211533.1 ENSMUST00000211533.2 NR_152217 uc009gwj.1 uc009gwj.2 uc009gwj.3 uc009gwj.4 uc009gwj.1 uc009gwj.2 uc009gwj.3 uc009gwj.4 
ENSMUST00000211539.2 Gm45537 ENSMUST00000211539.2 Gm45537 (from geneSymbol) ENSMUST00000211539.1 uc291ztu.1 uc291ztu.2 uc291ztu.1 uc291ztu.2 
ENSMUST00000211548.2 Gm45587 ENSMUST00000211548.2 Gm45587 (from geneSymbol) ENSMUST00000211548.1 uc291zfe.1 uc291zfe.2 uc291zfe.1 uc291zfe.2 
ENSMUST00000211554.2 Cyld ENSMUST00000211554.2 CYLD lysine 63 deubiquitinase, transcript variant 4 (from RefSeq NM_001128171.2) CYLD_MOUSE Cyld1 ENSMUST00000211554.1 Kiaa0849 NM_001128171 Q80TQ2 Q80VB3 Q8BXZ3 Q8BYL9 Q8CGB0 uc009mru.1 uc009mru.2 uc009mru.3 uc009mru.4 uc009mru.5 This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]. Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:17548520, PubMed:28701375, PubMed:29291351, PubMed:32185393, PubMed:32424362). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:16713561). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF- kappa-B activation (PubMed:16713561). Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha- tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:16713561, PubMed:20194890, PubMed:19893491). Required for normal cell cycle progress and normal cytokinesis (PubMed:19893491). Inhibits nuclear translocation of NF- kappa-B (By similarity). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (By similarity). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (PubMed:16501569, PubMed:18643924). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (PubMed:18382763). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (PubMed:25134987). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:28701375). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (By similarity). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (PubMed:28701375). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (PubMed:32424362). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:17548520, PubMed:29291351). Removes also 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts (via CAP-Gly domain) with IKBKG/NEMO (via proline- rich C-terminal region) (By similarity). Interacts with TRAF2 and TRIP (By similarity). Interacts with PLK1, DVL1, DVL3, MAVS, TBK1, IKKE and RIGI (By similarity). Interacts (via CAP-Gly domain) with microtubules (PubMed:19893491). Interacts with HDAC6 and BCL3 (PubMed:16713561, PubMed:19893491). Interacts with MAP3K7 (PubMed:17548520). Identified in a complex with TRAF6 and SQSTM1 (PubMed:18382763). Interacts with OPTN and SQSTM1 (By similarity). Interacts with CEP350 (By similarity). Interacts with RNF31; the interaction is indirect and is mediated via SPATA2 (By similarity). Interacts with SPATA2 (via the PUB domain); the interaction is direct and recruits CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (By similarity). Q80TQ2; Q9Z2F6: Bcl3; NbExp=5; IntAct=EBI-943859, EBI-943884; Q80TQ2; Q9Z2V5: Hdac6; NbExp=3; IntAct=EBI-943859, EBI-1009256; Q80TQ2; Q8C863: Itch; NbExp=2; IntAct=EBI-943859, EBI-851782; Q80TQ2; P68369: Tuba1a; NbExp=5; IntAct=EBI-943859, EBI-400542; Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, cilium basal body Note=Detected at the microtubule cytoskeleton during interphase (By similarity). Detected at the midbody during telophase (By similarity). During metaphase, it remains localized to the centrosome but is also present along the spindle (By similarity). Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=Q80TQ2-1; Sequence=Displayed; Name=1; IsoId=Q80TQ2-2; Sequence=VSP_011278; Name=3; IsoId=Q80TQ2-3; Sequence=VSP_011279, VSP_011280; Up-regulated by TNFRSF11A. Phosphorylated on several serine residues by IKKA and/or IKKB in response to immune stimuli. Phosphorylation requires IKBKG. Phosphorylation abolishes TRAF2 deubiquitination, interferes with the activation of Jun kinases, and strongly reduces CD40-dependent gene activation by NF-kappa-B (By similarity). Ubiquitinated. Polyubiquitinated in hepatocytes treated with palmitic acid. Ubiquitination is mediated by E3 ligase TRIM47 and leads to proteasomal degradation. No obvious phenotype, but mice are highly susceptible to carcinogens and are prone to chemically induced skin tumors (PubMed:16501569, PubMed:16713561, PubMed:17548520, PubMed:18382763, PubMed:18643924). The number of natural killer T-cells is much reduced (PubMed:16501569, PubMed:16713561, PubMed:17548520, PubMed:18382763, PubMed:18643924). Animals are highly susceptible to bacteria-induced pneumonia, due to an over active innate immune response (PubMed:16501569, PubMed:16713561, PubMed:17548520, PubMed:18382763, PubMed:18643924). Mice are more susceptible to C.rodentium infection, leading to severe inflammation in the intestine (PubMed:32424362). Animals spontaneously develop colonic inflammation, due to constitutive expression of several pro-inflammatory genes in the colon (PubMed:16501569, PubMed:16713561, PubMed:17548520, PubMed:18382763, PubMed:18643924). Animals exhibit abnormal osteoclast differentiation, leading to osteoporosis (PubMed:16501569, PubMed:16713561, PubMed:17548520, PubMed:18382763, PubMed:18643924). Hepatocyte-specific knockout mice do not exhibit any liver-related pathological phenotype under unstressed conditions (PubMed:29291351). In response to a 24-week high fat dier, they exhibit higher body and liver weight as well as reduced glucose tolerance and insulin resistance compared to controls (PubMed:29291351). They also show a considerable inflammatory response, including elevation of cytokine and chemokine concentrations in serum and mRNA expression in liver (PubMed:29291351). Belongs to the peptidase C19 family. Sequence=BAC65671.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; immune system process thiol-dependent ubiquitin-specific protease activity protein binding cytoplasm centrosome microtubule organizing center spindle cytosol cytoskeleton microtubule cytoplasmic microtubule plasma membrane proteolysis ubiquitin-dependent protein catabolic process regulation of mitotic cell cycle peptidase activity cysteine-type peptidase activity zinc ion binding regulation of tumor necrosis factor-mediated signaling pathway membrane Wnt signaling pathway protein deubiquitination hydrolase activity protein kinase binding midbody extrinsic component of cytoplasmic side of plasma membrane negative regulation of NF-kappaB transcription factor activity ciliary basal body thiol-dependent ubiquitinyl hydrolase activity cell projection CD4-positive or CD8-positive, alpha-beta T cell lineage commitment regulation of protein binding innate immune response regulation of B cell differentiation positive regulation of T cell differentiation negative regulation of JNK cascade metal ion binding perinuclear region of cytoplasm homeostasis of number of cells regulation of inflammatory response regulation of T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway regulation of necroptotic process Lys63-specific deubiquitinase activity proline-rich region binding necroptotic process regulation of microtubule cytoskeleton organization protein K63-linked deubiquitination protein K48-linked deubiquitination negative regulation of canonical Wnt signaling pathway ciliary tip ripoptosome assembly involved in necroptotic process negative regulation of NIK/NF-kappaB signaling regulation of cilium assembly negative regulation of p38MAPK cascade positive regulation of cellular protein localization protein linear deubiquitination Lys48-specific deubiquitinase activity positive regulation of extrinsic apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway uc009mru.1 uc009mru.2 uc009mru.3 uc009mru.4 uc009mru.5 
ENSMUST00000211556.2 Gm10683 ENSMUST00000211556.2 predicted gene 10683 (from RefSeq NR_188712.1) ENSMUST00000211556.1 NR_188712 uc291zjq.1 uc291zjq.2 uc291zjq.1 uc291zjq.2 
ENSMUST00000211557.2 Gm4224 ENSMUST00000211557.2 predicted gene 4224 (from RefSeq NR_046074.1) ENSMUST00000211557.1 NR_046074 uc029wdp.1 uc029wdp.2 uc029wdp.1 uc029wdp.2 
ENSMUST00000211562.3 Gm33175 ENSMUST00000211562.3 Gm33175 (from geneSymbol) ENSMUST00000211562.1 ENSMUST00000211562.2 uc291yfn.1 uc291yfn.2 uc291yfn.3 uc291yfn.1 uc291yfn.2 uc291yfn.3 
ENSMUST00000211572.2 Gm30329 ENSMUST00000211572.2 predicted gene, 30329 (from RefSeq NR_188779.1) ENSMUST00000211572.1 NR_188779 uc292bfy.1 uc292bfy.2 uc292bfy.1 uc292bfy.2 
ENSMUST00000211580.2 Gm45686 ENSMUST00000211580.2 Gm45686 (from geneSymbol) ENSMUST00000211580.1 uc291wpk.1 uc291wpk.2 uc291wpk.1 uc291wpk.2 
ENSMUST00000211582.2 Or5ae2 ENSMUST00000211582.2 olfactory receptor family 5 subfamily AE member 2 (from RefSeq NM_146415.2) ENSMUST00000211582.1 NM_146415 Olfr291 Or5ae2 Q8VF60 Q8VF60_MOUSE uc009iep.1 uc009iep.2 uc009iep.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB173249.1, DR065668.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009iep.1 uc009iep.2 uc009iep.3 
ENSMUST00000211586.2 Gm45584 ENSMUST00000211586.2 Gm45584 (from geneSymbol) ENSMUST00000211586.1 uc291zan.1 uc291zan.2 uc291zan.1 uc291zan.2 
ENSMUST00000211588.2 Gm45516 ENSMUST00000211588.2 Gm45516 (from geneSymbol) ENSMUST00000211588.1 uc292aeu.1 uc292aeu.2 uc292aeu.1 uc292aeu.2 
ENSMUST00000211591.2 Krtap5-24 ENSMUST00000211591.2 Krtap5-24 (from geneSymbol) A0A1B0GR10 A0A1B0GR10_MOUSE ENSMUST00000211591.1 Gm40460 uc291xhs.1 uc291xhs.2 intermediate filament keratin filament uc291xhs.1 uc291xhs.2 
ENSMUST00000211601.2 Tnpo2 ENSMUST00000211601.2 transportin 2 (importin 3, karyopherin beta 2b), transcript variant 6 (from RefSeq NM_001364034.1) ENSMUST00000211601.1 NM_001364034 Q8C0U9 Q99LG2 TNPO2_MOUSE uc009mpa.1 uc009mpa.2 uc009mpa.3 uc009mpa.4 uc009mpa.5 Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Cytoplasm Nucleus Belongs to the importin beta family. Importin beta-2 subfamily. protein binding nucleus cytoplasm protein import into nucleus intracellular protein transport nuclear localization sequence binding Ran GTPase binding protein transport negative regulation of muscle cell differentiation nuclear import signal receptor activity uc009mpa.1 uc009mpa.2 uc009mpa.3 uc009mpa.4 uc009mpa.5 
ENSMUST00000211613.2 Gm45479 ENSMUST00000211613.2 Gm45479 (from geneSymbol) ENSMUST00000211613.1 uc291zte.1 uc291zte.2 uc291zte.1 uc291zte.2 
ENSMUST00000211617.2 Cks1brt ENSMUST00000211617.2 CDC28 protein kinase 1b, retrogene (from RefSeq NM_001037922.3) Cks1brt EG624855 ENSMUST00000211617.1 Gm6531 NM_001037922 Q3UNC9 Q3UNC9_MOUSE uc009mpm.1 uc009mpm.2 Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. Forms a homohexamer that can probably bind six kinase subunits. Belongs to the CKS family. regulation of cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein kinase holoenzyme complex cell cycle regulation of mitotic cell cycle cyclin-dependent protein serine/threonine kinase regulator activity SCF ubiquitin ligase complex protein kinase binding histone binding ubiquitin binding positive regulation of cyclin-dependent protein serine/threonine kinase activity cell division cyclin-dependent protein serine/threonine kinase activator activity uc009mpm.1 uc009mpm.2 
ENSMUST00000211623.2 Eid3 ENSMUST00000211623.2 EP300 interacting inhibitor of differentiation 3 (from RefSeq NM_025499.2) EID3_MOUSE ENSMUST00000211623.1 Eid3 NM_025499 Q3TTL4 Q3V124 Q4KL03 Q8CF34 Q9CVN8 uc007gkc.1 uc007gkc.2 uc007gkc.3 Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double- strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300- dependent transcription factors (By similarity). Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3; EID3 seems to be a testis-specific subunit. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Homodimer, and heterodimer with EID2. Interacts with the C-terminal region of CREBBP (By similarity). Nucleus Cytoplasm Chromosome, telomere Note=May shuttle between nucleus and cytoplasm. Belongs to the NSE4 family. Sequence=AAH99545.1; Type=Erroneous initiation; Evidence=; Sequence=BAC25142.1; Type=Erroneous initiation; Evidence=; chromosome, telomeric region nucleus chromosome nucleolus cytoplasm DNA repair DNA recombination cellular response to DNA damage stimulus Smc5-Smc6 complex positive regulation of response to DNA damage stimulus uc007gkc.1 uc007gkc.2 uc007gkc.3 
ENSMUST00000211634.2 Gm45393 ENSMUST00000211634.2 Gm45393 (from geneSymbol) ENSMUST00000211634.1 uc291yne.1 uc291yne.2 uc291yne.1 uc291yne.2 
ENSMUST00000211642.2 Gm45322 ENSMUST00000211642.2 Gm45322 (from geneSymbol) AB349435 ENSMUST00000211642.1 uc291zvw.1 uc291zvw.2 uc291zvw.1 uc291zvw.2 
ENSMUST00000211649.2 Slc8a2 ENSMUST00000211649.2 solute carrier family 8 (sodium/calcium exchanger), member 2, transcript variant 1 (from RefSeq NM_148946.3) ENSMUST00000211649.1 NAC2_MOUSE NM_148946 Ncx2 Q68EG0 Q8K596 Q8R504 Slc8a2 uc009fgz.1 uc009fgz.2 uc009fgz.3 Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:12818181). Contributes to cellular Ca(2+) homeostasis in excitable cells (PubMed:12818181). Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (PubMed:12818181). Plays a role in regulating urinary Ca(2+) and Na(+) excretion (PubMed:25498502). Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in); Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108; Evidence=; Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+). Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K596-1; Sequence=Displayed; Name=2; IsoId=Q8K596-2; Sequence=VSP_057980; Detected in kidney cortex, in distal convoluted tubules and connecting segments (PubMed:25498502). Detected in brain and spinal cord (at protein level) (PubMed:12818181). Detected in brain, especially in hippocampus CA1, CA2 and CA3 fiels, dentate gyrus, cerebellum and brain cortex (PubMed:12818181). The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium- regulated ion exchange. No obvious phenotype. In hippocampus pyramidal neurons, calcium exchange activity is reduced by about half, suggesting that other, additional calcium exchangers are active in these neurons. In these neurons, the neurotransmitter glutamate triggers a sharp increase in cellular Ca(2+) that does not depend on calcium exchanger activity. In contrast, the decrease to basal levels is mediated by calcium exchangers, and is considerably slower in mutant mice than in wild-type. Basal synaptic function is not impaired in mutant mice, but they display enhanced short-term plasticity and facilitated long-term potentiation, probably due to the slower decrease of Ca(2+) after an initial impulse. Mutant mice display an increased capacity for spatial learning and memory (PubMed:12818181). Heterozygous mutants show increased basal urine volume and increased urinary secretion of Ca(2+) and Na(+) (PubMed:25498502). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. calcium:sodium antiporter activity calmodulin binding mitochondrion microtubule plasma membrane integral component of plasma membrane ion transport sodium ion transport calcium ion transport cellular calcium ion homeostasis cell communication learning memory antiporter activity membrane integral component of membrane basolateral plasma membrane integral component of mitochondrial membrane sodium ion transmembrane transport cell projection neuronal cell body dendritic spine metal ion binding regulation of short-term neuronal synaptic plasticity transmembrane transport long-term synaptic potentiation calcium ion transport into cytosol calcium ion transmembrane transport calcium ion import across plasma membrane postsynapse integral component of postsynaptic membrane regulation of postsynaptic cytosolic calcium ion concentration calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration calcium ion export from cell uc009fgz.1 uc009fgz.2 uc009fgz.3 
ENSMUST00000211651.3 Gm32975 ENSMUST00000211651.3 predicted gene, 32975 (from RefSeq NR_188754.1) ENSMUST00000211651.1 ENSMUST00000211651.2 NR_188754 uc291zwh.1 uc291zwh.2 uc291zwh.3 uc291zwh.1 uc291zwh.2 uc291zwh.3 
ENSMUST00000211653.4 5830408C22Rik ENSMUST00000211653.4 5830408C22Rik (from geneSymbol) ENSMUST00000211653.1 ENSMUST00000211653.2 ENSMUST00000211653.3 uc291yvi.1 uc291yvi.2 uc291yvi.3 uc291yvi.4 uc291yvi.1 uc291yvi.2 uc291yvi.3 uc291yvi.4 
ENSMUST00000211661.3 Gm45809 ENSMUST00000211661.3 Gm45809 (from geneSymbol) ENSMUST00000211661.1 ENSMUST00000211661.2 LF196947 uc292adk.1 uc292adk.2 uc292adk.1 uc292adk.2 
ENSMUST00000211663.3 Gm13848 ENSMUST00000211663.3 Gm13848 (from geneSymbol) AK085570 ENSMUST00000211663.1 ENSMUST00000211663.2 uc291dim.1 uc291dim.2 uc291dim.3 uc291dim.1 uc291dim.2 uc291dim.3 
ENSMUST00000211674.2 Kcnj11 ENSMUST00000211674.2 potassium inwardly rectifying channel, subfamily J, member 11, transcript variant 1 (from RefSeq NM_010602.4) ENSMUST00000211674.1 KCJ11_MOUSE NM_010602 Q61743 Q9QX21 uc009gyc.1 uc009gyc.2 uc009gyc.3 uc009gyc.4 This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity). Interacts with ABCC9/SUR2 (By similarity). Interacts with ABCC8/SUR. Q61743; Q8C8R3: Ank2; NbExp=2; IntAct=EBI-8603527, EBI-774322; Q61743; O94973: AP2A2; Xeno; NbExp=2; IntAct=EBI-8603527, EBI-1642835; Q61743; G3I1T3: I79_017352; Xeno; NbExp=3; IntAct=EBI-8603527, EBI-10953250; Membrane; Multi-pass membrane protein. Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily. acrosomal vesicle response to ischemia inward rectifier potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity protein binding ATP binding nuclear envelope mitochondrion endosome endoplasmic reticulum cytosol plasma membrane glucose metabolic process ion transport potassium ion transport protein C-terminus binding ATP-sensitive potassium channel complex intercalated disc ATP-activated inward rectifier potassium channel activity membrane integral component of membrane T-tubule ankyrin binding axolemma potassium ion binding heat shock protein binding response to estradiol response to ATP response to testosterone regulation of ion transmembrane transport sarcolemma regulation of membrane potential response to drug neuronal cell body myelin sheath intracellular membrane-bounded organelle ion channel binding negative regulation of insulin secretion regulation of insulin secretion neurological system process cell body fiber cellular response to nicotine cellular response to glucose stimulus cellular response to tumor necrosis factor potassium ion transmembrane transport positive regulation of protein localization to plasma membrane potassium ion import across plasma membrane positive regulation of cation channel activity uc009gyc.1 uc009gyc.2 uc009gyc.3 uc009gyc.4 
ENSMUST00000211687.2 Sorcs1 ENSMUST00000211687.2 sortilin-related VPS10 domain containing receptor 1, transcript variant 1 (from RefSeq NM_021377.4) A0A1B0GRN1 A0A1B0GRN1_MOUSE ENSMUST00000211687.1 NM_021377 Sorcs1 uc008hwa.1 uc008hwa.2 uc008hwa.3 uc008hwa.4 uc008hwa.5 uc008hwa.6 Belongs to the VPS10-related sortilin family. SORCS subfamily. membrane integral component of membrane uc008hwa.1 uc008hwa.2 uc008hwa.3 uc008hwa.4 uc008hwa.5 uc008hwa.6 
ENSMUST00000211700.2 4930412F12Rik ENSMUST00000211700.2 4930412F12Rik (from geneSymbol) ENSMUST00000211700.1 uc292abj.1 uc292abj.2 uc292abj.1 uc292abj.2 
ENSMUST00000211703.2 Gm45602 ENSMUST00000211703.2 Gm45602 (from geneSymbol) ENSMUST00000211703.1 uc292bgf.1 uc292bgf.2 uc292bgf.1 uc292bgf.2 
ENSMUST00000211710.2 Gm45871 ENSMUST00000211710.2 predicted gene 45871 (from RefSeq NM_001362365.1) A0A1B0GRI9 A0A1B0GRI9_MOUSE ENSMUST00000211710.1 Gm45871 NM_001362365 uc289pwu.1 uc289pwu.2 May be involved in transcriptional regulation. transcription regulatory region sequence-specific DNA binding nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated sequence-specific DNA binding metal ion binding uc289pwu.1 uc289pwu.2 
ENSMUST00000211713.2 Grin2d ENSMUST00000211713.2 glutamate receptor, ionotropic, NMDA2D (epsilon 4) (from RefSeq NM_008172.3) C9K0Z5 ENSMUST00000211713.1 GluN2D NMDE4_MOUSE NM_008172 Q03391 uc291pya.1 uc291pya.2 Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1385220). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro) (PubMed:1385220). In vivo, the subunit composition may depend on the expression levels of the different subunits (Probable). Interacts with PDZ domains of PATJ and DLG4 (By similarity). Cell membrane ; Multi-pass membrane protein Postsynaptic cell membrane ; Multi-pass membrane protein Detected in neonate brain synaptosomes (at protein level). A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter. Mice are born at the expected Mendelian rate, are viable and fertile. Their brains appear grossly normal. Mutant mice show reduced spontaneous locomotion activity, but have no visible impairment of motor skills. They have normal exploratory behavior, but their behavior in a new situation suggests increased novelty preference. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily. startle response ionotropic glutamate receptor activity NMDA glutamate receptor activity ion channel activity cation channel activity plasma membrane integral component of plasma membrane ion transport glutamate receptor activity adult locomotory behavior ligand-gated ion channel activity membrane integral component of membrane glutamate binding NMDA selective glutamate receptor complex calcium-mediated signaling voltage-gated cation channel activity glutamate-gated calcium ion channel activity cell junction ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic signaling receptor activity neurotransmitter binding synapse postsynaptic membrane modulation of synaptic transmission regulation of sensory perception of pain excitatory postsynaptic potential long-term synaptic potentiation calcium ion transmembrane import into cytosol postsynaptic density membrane glutamatergic synapse integral component of postsynaptic density membrane transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential detection of mechanical stimulus involved in sensory perception of pain uc291pya.1 uc291pya.2 
ENSMUST00000211726.2 Gm45461 ENSMUST00000211726.2 Gm45461 (from geneSymbol) ENSMUST00000211726.1 uc292aet.1 uc292aet.2 uc292aet.1 uc292aet.2 
ENSMUST00000211738.2 Cdhr17 ENSMUST00000211738.2 cadherin related family member 17 (from RefSeq NM_001378608.1) A0A1B0GR31 A0A1B0GR31_MOUSE Cdhr17 ENSMUST00000211738.1 Gm28710 NM_001378608 uc290thp.1 uc290thp.2 calcium ion binding plasma membrane integral component of plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules sensory perception of sound membrane integral component of membrane stereocilium inner ear development uc290thp.1 uc290thp.2 
ENSMUST00000211740.2 Sult2a7 ENSMUST00000211740.2 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 7 (from RefSeq NM_001184981.2) A0A1B0GRF0 A0A1B0GRF0_MOUSE ENSMUST00000211740.1 NM_001184981 Sult2a7 uc291luq.1 uc291luq.2 This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Belongs to the sulfotransferase 1 family. molecular_function cellular_component sulfotransferase activity biological_process transferase activity uc291luq.1 uc291luq.2 
ENSMUST00000211753.2 Gm45489 ENSMUST00000211753.2 Gm45489 (from geneSymbol) ENSMUST00000211753.1 uc291zdt.1 uc291zdt.2 uc291zdt.1 uc291zdt.2 
ENSMUST00000211758.2 Gm45453 ENSMUST00000211758.2 Gm45453 (from geneSymbol) ENSMUST00000211758.1 uc291yrl.1 uc291yrl.2 uc291yrl.1 uc291yrl.2 
ENSMUST00000211765.2 Nucb1 ENSMUST00000211765.2 nucleobindin 1, transcript variant 1 (from RefSeq NM_001163662.2) ENSMUST00000211765.1 NM_001163662 NUCB1_MOUSE Nuc Nucb Q02819 Q3TU42 Q9CWA1 Q9D8J4 Q9DBL3 uc009gvn.1 uc009gvn.2 uc009gvn.3 uc009gvn.4 Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunits GNAI1, GNAI2 and GNAI3 with higher affinity for GNAI1 and GNAI3 than for GNAI2. Preferentially interacts with inactive rather than active GNAI3. Interaction with GNAI3 is inhibited when NUCB1 binds calcium, probably due to a conformational change which renders the GBA motif inaccessible. Golgi apparatus, cis-Golgi network membrane ; Peripheral membrane protein ; Lumenal side Cytoplasm Secreted Note=A small fraction of the protein may be cytoplasmic. In bone at least part of it is found in the extracellular matrix and in the culture medium of calvaria explants (By similarity). In lupus prone, but not in normal mice, at least part of it is in the serum where it induces the formation of autoantibodies including anti-DNA antibodies. Lymphoid cells as well as other somatic cells, such as liver and kidney cells. The EF-hand domains are unfolded in the absence of Ca(2+) and fold upon Ca(2+) addition. The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins). Discovered as DNA-binding protein in the serum of lupus- prone mice. Belongs to the nucleobindin family. G-protein alpha-subunit binding DNA binding calcium ion binding extracellular region extracellular space nucleus cytoplasm early endosome rough endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus Golgi-associated vesicle cis-Golgi network trans-Golgi network membrane Golgi cisterna membrane metal ion binding response to cisplatin extrinsic component of Golgi membrane lumenal side of Golgi membrane regulation of protein targeting uc009gvn.1 uc009gvn.2 uc009gvn.3 uc009gvn.4 
ENSMUST00000211767.2 Gm45486 ENSMUST00000211767.2 Gm45486 (from geneSymbol) AK087377 ENSMUST00000211767.1 uc291pzs.1 uc291pzs.2 uc291pzs.1 uc291pzs.2 
ENSMUST00000211772.2 Gm45379 ENSMUST00000211772.2 Gm45379 (from geneSymbol) ENSMUST00000211772.1 uc291liz.1 uc291liz.2 uc291liz.1 uc291liz.2 
ENSMUST00000211774.3 Gm45572 ENSMUST00000211774.3 Gm45572 (from geneSymbol) ENSMUST00000211774.1 ENSMUST00000211774.2 uc291zav.1 uc291zav.2 uc291zav.3 uc291zav.1 uc291zav.2 uc291zav.3 
ENSMUST00000211799.2 5430402P08Rik ENSMUST00000211799.2 5430402P08Rik (from geneSymbol) AK017263 ENSMUST00000211799.1 uc291ung.1 uc291ung.2 uc291ung.1 uc291ung.2 
ENSMUST00000211815.2 Gm45865 ENSMUST00000211815.2 Gm45865 (from geneSymbol) ENSMUST00000211815.1 uc292dzm.1 uc292dzm.2 uc292dzm.1 uc292dzm.2 
ENSMUST00000211816.2 Nlrc5 ENSMUST00000211816.2 Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. (from UniProt C3VPR6) C3VPR6 ENSMUST00000211816.1 FJ889356 NLRC5_MOUSE Q571H9 uc292cew.1 uc292cew.2 Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity. Interacts with RIGI and IFIH1; blocks the interaction of MAVS to RIGI. Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=C3VPR6-1; Sequence=Displayed; Name=2; IsoId=C3VPR6-2; Sequence=VSP_039702, VSP_039703; Expressed in spleen, thymus and lung. By interferon gamma. By LPS and viruses (at protein level). [Isoform 2]: Due to intron retention. Belongs to the NLRP family. Supposed to contain a CARD domain at the N-terminus. However, this domain is not detected by Pfam, PROSITE or SMART. Has a weak similarity with a DAPIN domain. nucleotide binding RNA polymerase II core promoter proximal region sequence-specific DNA binding immune system process ATP binding nucleus cytoplasm centrosome cytosol response to bacterium negative regulation of NF-kappaB transcription factor activity intracellular signal transduction regulation of kinase activity innate immune response positive regulation of MHC class I biosynthetic process positive regulation of transcription from RNA polymerase II promoter defense response to virus positive regulation of interferon-gamma-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway positive regulation of type I interferon-mediated signaling pathway uc292cew.1 uc292cew.2 
ENSMUST00000211831.2 Gm45705 ENSMUST00000211831.2 Gm45705 (from geneSymbol) ENSMUST00000211831.1 uc292bbl.1 uc292bbl.2 uc292bbl.1 uc292bbl.2 
ENSMUST00000211835.2 Gm45757 ENSMUST00000211835.2 Gm45757 (from geneSymbol) AK077285 ENSMUST00000211835.1 uc292cil.1 uc292cil.2 uc292cil.1 uc292cil.2 
ENSMUST00000211837.2 Ankar ENSMUST00000211837.2 ankyrin and armadillo repeat containing, transcript variant 2 (from RefSeq NM_001347063.1) Ankar B7ZNI2 B7ZNI2_MOUSE ENSMUST00000211837.1 NM_001347063 uc011wmv.1 uc011wmv.2 uc011wmv.3 uc011wmv.1 uc011wmv.2 uc011wmv.3 
ENSMUST00000211844.2 Gm45911 ENSMUST00000211844.2 Gm45911 (from geneSymbol) ENSMUST00000211844.1 uc292aho.1 uc292aho.2 uc292aho.1 uc292aho.2 
ENSMUST00000211848.2 Potefam3f ENSMUST00000211848.2 Potefam3f (from geneSymbol) A0A1D5RM70 A0A1D5RM70_MOUSE AK076593 ENSMUST00000211848.1 Gm31371 Potefam3f uc291you.1 uc291you.2 uc291you.1 uc291you.2 
ENSMUST00000211851.3 Or8b101 ENSMUST00000211851.3 Membrane ; Multi- pass membrane protein (from UniProt A0A1D5RLR5) A0A1D5RLR5 A0A1D5RLR5_MOUSE ENSMUST00000211851.1 ENSMUST00000211851.2 Olfr888 Or8b101 uc292fxe.1 uc292fxe.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fxe.1 uc292fxe.2 
ENSMUST00000211852.2 4933405L10Rik ENSMUST00000211852.2 RIKEN cDNA 4933405L10 gene, transcript variant 2 (from RefSeq NM_001357256.1) B7ZN89 CP086_MOUSE ENSMUST00000211852.1 NM_001357256 Q9D4A5 uc012gjo.1 uc012gjo.2 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D4A5-1; Sequence=Displayed; Name=2; IsoId=Q9D4A5-2; Sequence=VSP_040246; molecular_function cellular_component biological_process uc012gjo.1 uc012gjo.2 
ENSMUST00000211856.3 Gm45702 ENSMUST00000211856.3 Gm45702 (from geneSymbol) ENSMUST00000211856.1 ENSMUST00000211856.2 uc292ckx.1 uc292ckx.2 uc292ckx.3 uc292ckx.1 uc292ckx.2 uc292ckx.3 
ENSMUST00000211857.2 Gm45854 ENSMUST00000211857.2 Gm45854 (from geneSymbol) AK045868 ENSMUST00000211857.1 uc292ckk.1 uc292ckk.2 uc292ckk.1 uc292ckk.2 
ENSMUST00000211864.2 ENSMUSG00000121425 ENSMUST00000211864.2 ENSMUSG00000121425 (from geneSymbol) ENSMUST00000211864.1 uc292csu.1 uc292csu.2 uc292csu.1 uc292csu.2 
ENSMUST00000211865.2 Gm45873 ENSMUST00000211865.2 Gm45873 (from geneSymbol) AK157776 ENSMUST00000211865.1 uc292cdp.1 uc292cdp.2 uc292cdp.1 uc292cdp.2 
ENSMUST00000211875.2 Mup22 ENSMUST00000211875.2 major urinary protein 22 (from RefSeq NM_001347154.1) ENSMUST00000211875.1 Mup1 Mup22 NM_001347154 Q4FZE8 Q4FZE8_MOUSE uc029uut.1 uc029uut.2 uc029uut.3 uc029uut.4 Secreted Belongs to the calycin superfamily. Lipocalin family. small molecule binding uc029uut.1 uc029uut.2 uc029uut.3 uc029uut.4 
ENSMUST00000211876.2 Gm45842 ENSMUST00000211876.2 Gm45842 (from geneSymbol) AK016841 ENSMUST00000211876.1 uc292dwp.1 uc292dwp.2 uc292dwp.1 uc292dwp.2 
ENSMUST00000211881.2 Gm45720 ENSMUST00000211881.2 Gm45720 (from geneSymbol) ENSMUST00000211881.1 uc292dko.1 uc292dko.2 uc292dko.1 uc292dko.2 
ENSMUST00000211887.2 Cnot1 ENSMUST00000211887.2 CCR4-NOT transcription complex, subunit 1, transcript variant 2 (from RefSeq NM_178078.3) A0A1D5RMJ8 A0A1D5RMJ8_MOUSE Cnot1 ENSMUST00000211887.1 NM_178078 uc009mzd.1 uc009mzd.2 uc009mzd.3 uc009mzd.4 uc009mzd.5 Nucleus Belongs to the CNOT1 family. negative regulation of transcription from RNA polymerase II promoter P-body poly(A)-specific ribonuclease activity cytosol regulation of translation positive regulation of cytoplasmic mRNA processing body assembly negative regulation of translation protein domain specific binding CCR4-NOT complex CCR4-NOT core complex estrogen receptor binding negative regulation of intracellular estrogen receptor signaling pathway gene silencing by miRNA retinoic acid receptor binding negative regulation of retinoic acid receptor signaling pathway binding, bridging positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of mRNA catabolic process armadillo repeat domain binding RNA phosphodiester bond hydrolysis, exonucleolytic positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of stem cell population maintenance uc009mzd.1 uc009mzd.2 uc009mzd.3 uc009mzd.4 uc009mzd.5 
ENSMUST00000211893.2 Or8a1 ENSMUST00000211893.2 olfactory receptor family 8 subfamily A member 1, transcript variant 1, non-coding (from RefSeq NR_160653.1) ENSMUST00000211893.1 NR_160653 uc057lzg.1 uc057lzg.2 uc057lzg.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene appears to represent a strain-specific polymorphic pseudogene in mouse, where some strains, including the C57BL/6 reference genome strain, have a non-functional allele, while other strains have a protein-coding allele. [provided by RefSeq, Jan 2019]. uc057lzg.1 uc057lzg.2 uc057lzg.3 
ENSMUST00000211896.2 Btbd8 ENSMUST00000211896.2 BTB domain containing 8, transcript variant 1 (from RefSeq NM_001378266.2) A0A1D5RL96 BTBD8_MOUSE Btbd8 D3YUB6 E9PUC9 E9QLA8 ENSMUST00000211896.1 Gm16115 Kiaa1107 NM_001378266 Q3TPG8 Q80TK0 Q8BRQ7 Q8BRS6 uc290xvs.1 uc290xvs.2 Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission. Interacts (via N-terminus) with adapter protein complex AP-2 subunits alpha (AP2A1) and beta (AP2B1). Cell projection, axon Presynapse Cytoplasmic vesicle, clathrin-coated vesicle Nucleus Note=In primary cultures, mainly present at axonal and presynaptic terminal levels of mature neurons. In immature neurons, localizes to the cell body and growing processes, including axons (PubMed:29262337). Localized to nucleus in fetal cells (By similarity). Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=D3YUB6-2; Sequence=Displayed; Name=3; IsoId=D3YUB6-3; Sequence=VSP_061631; Neuron-specific protein. Primarily expressed in brain, with the highest levels in the cerebral cortex, hippocampus, and striatum (at protein level). Not detected in glial cells. In the developing brain cortex, expressed at 18 dpc. Expression increases during postnatal development to reach a plateau at 1 month of age. Sequence=BAC31589.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC31628.1; Type=Frameshift; Evidence=; Sequence=BAC65726.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAE37768.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleus nucleoplasm uc290xvs.1 uc290xvs.2 
ENSMUST00000211900.2 Gm45766 ENSMUST00000211900.2 Gm45766 (from geneSymbol) ENSMUST00000211900.1 uc292ccm.1 uc292ccm.2 uc292ccm.1 uc292ccm.2 
ENSMUST00000211903.2 Cdh16 ENSMUST00000211903.2 cadherin 16, transcript variant 1 (from RefSeq NM_007663.3) Cdh16 ENSMUST00000211903.1 NM_007663 Q546A8 Q546A8_MOUSE uc009nax.1 uc009nax.2 uc009nax.3 uc009nax.4 calcium ion binding plasma membrane homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules uc009nax.1 uc009nax.2 uc009nax.3 uc009nax.4 
ENSMUST00000211921.3 Gm31805 ENSMUST00000211921.3 Gm31805 (from geneSymbol) ENSMUST00000211921.1 ENSMUST00000211921.2 uc292cmj.1 uc292cmj.2 uc292cmj.3 uc292cmj.1 uc292cmj.2 uc292cmj.3 
ENSMUST00000211925.2 Gm31518 ENSMUST00000211925.2 Gm31518 (from geneSymbol) ENSMUST00000211925.1 uc292ckt.1 uc292ckt.2 uc292ckt.1 uc292ckt.2 
ENSMUST00000211931.2 Gm45833 ENSMUST00000211931.2 Gm45833 (from geneSymbol) ENSMUST00000211931.1 uc292dqm.1 uc292dqm.2 uc292dqm.1 uc292dqm.2 
ENSMUST00000211933.2 Alkbh8 ENSMUST00000211933.2 alkB homolog 8, tRNA methyltransferase, transcript variant 4 (from RefSeq NM_001405038.1) ALKB8_MOUSE ENSMUST00000211933.1 NM_001405038 Q3TUG4 Q80Y20 Q8BV08 Q9CX44 uc292egh.1 uc292egh.2 Catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys) (By similarity). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)- methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:20583019). Required for normal survival after DNA damage (By similarity). May inhibit apoptosis and promote cell survival and angiogenesis (By similarity). Reaction=5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:43208, Rhea:RHEA-COMP:10407, Rhea:RHEA- COMP:10408, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74851, ChEBI:CHEBI:74882; EC=2.1.1.229; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence=; Note=Binds 1 Fe(2+) ion per subunit. ; Interacts with TRMT112. Cytoplasm Nucleus Note=Predominantly cytoplasmic. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q80Y20-1; Sequence=Displayed; Name=2; IsoId=Q80Y20-2; Sequence=VSP_033931; Name=3; IsoId=Q80Y20-3; Sequence=VSP_033929, VSP_033930; The Fe2OG dioxygenase domain does not have demethylase activity with methylated nucleotides. No visible phenotype. Belongs to the alkB family. Sequence=BAC38223.1; Type=Frameshift; Evidence=; tRNA binding tRNA wobble uridine modification nucleic acid binding RNA binding catalytic activity iron ion binding nucleus nucleoplasm cytoplasm cytosol cellular response to DNA damage stimulus metabolic process methyltransferase activity zinc ion binding tRNA (uracil) methyltransferase activity oxidoreductase activity nuclear body oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors transferase activity tRNA methylation methylation metal ion binding oxidation-reduction process uc292egh.1 uc292egh.2 
ENSMUST00000211948.2 Mast3 ENSMUST00000211948.2 microtubule associated serine/threonine kinase 3, transcript variant 5 (from RefSeq NM_199308.3) A0A1D5RM97 A0A1D5RM97_MOUSE ENSMUST00000211948.1 Mast3 NM_199308 uc009mbp.1 uc009mbp.2 uc009mbp.3 uc009mbp.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation kinase activity phosphorylation transferase activity uc009mbp.1 uc009mbp.2 uc009mbp.3 uc009mbp.4 
ENSMUST00000211951.2 Gm30052 ENSMUST00000211951.2 predicted gene, 30052 (from RefSeq NR_136914.1) ENSMUST00000211951.1 NR_136914 uc057lxx.1 uc057lxx.2 uc057lxx.1 uc057lxx.2 
ENSMUST00000211952.3 Or8a1b ENSMUST00000211952.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGE3) ENSMUST00000211952.1 ENSMUST00000211952.2 Olfr160 Or8a1b Q8VGE3 Q8VGE3_MOUSE uc292fwf.1 uc292fwf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway axon guidance sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fwf.1 uc292fwf.2 
ENSMUST00000211955.2 Gm45827 ENSMUST00000211955.2 Gm45827 (from geneSymbol) ENSMUST00000211955.1 uc292ahu.1 uc292ahu.2 uc292ahu.1 uc292ahu.2 
ENSMUST00000211965.2 Gm45864 ENSMUST00000211965.2 Gm45864 (from geneSymbol) ENSMUST00000211965.1 uc291zuq.1 uc291zuq.2 uc291zuq.1 uc291zuq.2 
ENSMUST00000211967.2 Gm45821 ENSMUST00000211967.2 Gm45821 (from geneSymbol) ENSMUST00000211967.1 uc292bbw.1 uc292bbw.2 uc292bbw.1 uc292bbw.2 
ENSMUST00000211969.2 K230015D01Rik ENSMUST00000211969.2 K230015D01Rik (from geneSymbol) AK158572 ENSMUST00000211969.1 uc292cqj.1 uc292cqj.2 uc292cqj.1 uc292cqj.2 
ENSMUST00000211986.2 Gm45790 ENSMUST00000211986.2 Gm45790 (from geneSymbol) ENSMUST00000211986.1 uc290ggu.1 uc290ggu.2 uc290ggu.1 uc290ggu.2 
ENSMUST00000211988.2 Gm45731 ENSMUST00000211988.2 Gm45731 (from geneSymbol) AK157527 ENSMUST00000211988.1 uc292cqg.1 uc292cqg.2 uc292cqg.1 uc292cqg.2 
ENSMUST00000211989.4 Gm31659 ENSMUST00000211989.4 Gm31659 (from geneSymbol) ENSMUST00000211989.1 ENSMUST00000211989.2 ENSMUST00000211989.3 uc292cmg.1 uc292cmg.2 uc292cmg.3 uc292cmg.4 uc292cmg.1 uc292cmg.2 uc292cmg.3 uc292cmg.4 
ENSMUST00000211998.2 Or8c14-ps1 ENSMUST00000211998.2 Or8c14-ps1 (from geneSymbol) ENSMUST00000211998.1 uc292fxi.1 uc292fxi.2 uc292fxi.1 uc292fxi.2 
ENSMUST00000212007.2 A530010L16Rik ENSMUST00000212007.2 A530010L16Rik (from geneSymbol) BC032935 ENSMUST00000212007.1 uc292dud.1 uc292dud.2 uc292dud.1 uc292dud.2 
ENSMUST00000212009.2 Ces5a ENSMUST00000212009.2 carboxylesterase 5A, transcript variant 1 (from RefSeq NM_001381850.1) Ces7 ENSMUST00000212009.1 EST5A_MOUSE NM_001381850 Q6AW46 uc033jgu.1 uc033jgu.2 uc033jgu.3 Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence=; Secreted N-glycosylated. Belongs to the type-B carboxylesterase/lipase family. sterol esterase activity triglyceride lipase activity extracellular region extracellular space lipid catabolic process hydrolase activity carboxylic ester hydrolase activity methyl indole-3-acetate esterase activity uc033jgu.1 uc033jgu.2 uc033jgu.3 
ENSMUST00000212013.4 Or7e166 ENSMUST00000212013.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRF7) ENSMUST00000212013.1 ENSMUST00000212013.2 ENSMUST00000212013.3 Olfr857 Olfr859 Or7e166 Q7TRF7 Q7TRF7_MOUSE uc292eui.1 uc292eui.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292eui.1 uc292eui.2 
ENSMUST00000212022.2 Gm45694 ENSMUST00000212022.2 Gm45694 (from geneSymbol) AK149297 ENSMUST00000212022.1 uc292ayu.1 uc292ayu.2 uc292ayu.1 uc292ayu.2 
ENSMUST00000212026.3 Gm36368 ENSMUST00000212026.3 Gm36368 (from geneSymbol) A0A1D5RLK8 A0A1D5RLK8_MOUSE ENSMUST00000212026.1 ENSMUST00000212026.2 Gm36368 uc289phs.1 uc289phs.2 uc289phs.3 uc289phs.1 uc289phs.2 uc289phs.3 
ENSMUST00000212027.2 Gm45765 ENSMUST00000212027.2 Gm45765 (from geneSymbol) AK135339 ENSMUST00000212027.1 uc292cci.1 uc292cci.2 uc292cci.1 uc292cci.2 
ENSMUST00000212031.2 Scoc ENSMUST00000212031.2 short coiled-coil protein, transcript variant 2 (from RefSeq NM_019708.4) B2RV68 ENSMUST00000212031.1 NM_019708 Q32NY7 Q3TJC8 Q58E48 Q5U450 Q78YZ6 Q9WU55 SCOC_MOUSE Scoco uc009mkf.1 uc009mkf.2 uc009mkf.3 uc009mkf.4 Positive regulator of amino acid starvation-induced autophagy. Homodimer. Interacts with ARL1, ARL2 and ARL3. Directly interacts with FEZ1 and UVRAG. The interaction with UVRAG is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. Interacts with NRBF2. Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Golgi apparatus, trans-Golgi network Cytoplasm, cytosol Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q78YZ6-1; Sequence=Displayed; Name=2; IsoId=Q78YZ6-2; Sequence=VSP_033646; Name=3; IsoId=Q78YZ6-3; Sequence=VSP_033646, VSP_033647; Belongs to the SCOC family. Golgi membrane molecular_function nucleoplasm cytoplasm endosome Golgi apparatus trans-Golgi network cytosol membrane positive regulation of macroautophagy regulation of protein complex stability uc009mkf.1 uc009mkf.2 uc009mkf.3 uc009mkf.4 
ENSMUST00000212051.2 Cracr2a ENSMUST00000212051.2 calcium release activated channel regulator 2A, transcript variant 1 (from RefSeq NM_001368877.1) A0A1D5RLZ8 B9EKF2 EFC4B_MOUSE ENSMUST00000212051.1 Efcab4b Gm1073 NM_001368877 Q3UP38 Rab46 uc291jea.1 uc291jea.2 [Isoform 1]: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex (By similarity). [Isoform 2]: Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli (By similarity). During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)- independent manner and its GTPase activity is essential for this function (By similarity). Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47 (By similarity). Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation (PubMed:27016526). In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways (By similarity). Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function (PubMed:29987160). Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation (By similarity). [Isoform 1]: Interacts with ORAI1 and STIM1; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with ORAI1 and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with ORAI2 and ORAI3. [Isoform 2]: Interacts with DYNC1H1 and VAV1 (By similarity). Interacts with the dynein-dynactin complex in a Ca(2+)-dependent manner (By similarity). [Isoform 1]: Cytoplasm [Isoform 2]: Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center Cell membrane Golgi apparatus membrane Golgi apparatus, trans-Golgi network membrane Vesicle Note=T-cell activation-induced elevation of intracellular of Ca(2+) stimulates its transport toward the microtubule organizing center (MTOC). Histamine stimulation induces a trafficking to the MTOC in a GTP-binding-dependent but Ca(2+)- binding-independent manner. Localizes to Golgi membrane in resting T- cells and upon its interaction with VAV1, is translocated from the Golgi membrane to the immunological synapse via subsynaptic vesicles. Its localization in the Golgi membrane requires isoprenylation and GTP- binding. Event=Alternative splicing; Named isoforms=2; Name=2; Synonyms=CRACR2A-A ; IsoId=Q3UP38-2; Sequence=Displayed; Name=1; IsoId=Q3UP38-1; Sequence=VSP_060979, VSP_060980; [Isoform 1]: Abundantly expressed in T helper 1 and T helper 17 cells. [Isoform 2]: Expressed in lymphoid organs including spleen and lymph nodes (PubMed:27016526). Abundantly expressed in T helper 1 and T helper 17 cells (PubMed:29987160). Belongs to the EFCAB4 family. store-operated calcium entry adaptive immune response immune system process calcium ion binding cytoplasm ion transport calcium ion transport activation of store-operated calcium channel activity metal ion binding positive regulation of calcium ion transport uc291jea.1 uc291jea.2 
ENSMUST00000212054.2 Tmem269 ENSMUST00000212054.2 transmembrane protein 269 (from RefSeq NM_029198.3) ENSMUST00000212054.1 NM_029198 Q9D4Y8 TM269_MOUSE Tmem269 uc008ulm.1 uc008ulm.2 Membrane ; Multi-pass membrane protein membrane integral component of membrane uc008ulm.1 uc008ulm.2 
ENSMUST00000212058.2 Nmur1 ENSMUST00000212058.2 neuromedin U receptor 1, transcript variant 1 (from RefSeq NM_001319227.1) ENSMUST00000212058.1 G5E871 Gpr66 NMUR1_MOUSE NM_001319227 O55040 Q0VB23 uc287kaj.1 uc287kaj.2 Receptor for the neuromedin-U and neuromedin-S neuropeptides. Cell membrane; Multi-pass membrane protein. Ubiquitously expressed. Belongs to the G-protein coupled receptor 1 family. Sequence=AAI20823.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAI37776.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=EDL40217.1; Type=Erroneous gene model prediction; Evidence=; neuromedin U receptor activity G-protein coupled receptor activity plasma membrane integral component of plasma membrane calcium ion transport chloride transport smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway activation of phospholipase C activity neuropeptide signaling pathway neuropeptide receptor activity membrane integral component of membrane calcium-mediated signaling neuromedin U binding inositol phosphate-mediated signaling uc287kaj.1 uc287kaj.2 
ENSMUST00000212067.2 1700112L15Rik ENSMUST00000212067.2 1700112L15Rik (from geneSymbol) AK007183 ENSMUST00000212067.1 uc292cko.1 uc292cko.2 uc292cko.1 uc292cko.2 
ENSMUST00000212068.2 Gm45820 ENSMUST00000212068.2 Gm45820 (from geneSymbol) ENSMUST00000212068.1 uc292bcn.1 uc292bcn.2 uc292bcn.1 uc292bcn.2 
ENSMUST00000212073.3 Gm32052 ENSMUST00000212073.3 Gm32052 (from geneSymbol) ENSMUST00000212073.1 ENSMUST00000212073.2 uc291zus.1 uc291zus.2 uc291zus.3 uc291zus.1 uc291zus.2 uc291zus.3 
ENSMUST00000212075.2 Msantd4 ENSMUST00000212075.2 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils (from RefSeq NM_145609.2) ENSMUST00000212075.1 MSD4_MOUSE NM_145609 Q91YU3 uc009obm.1 uc009obm.2 uc009obm.3 molecular_function nucleus biological_process uc009obm.1 uc009obm.2 uc009obm.3 
ENSMUST00000212088.2 Gm45696 ENSMUST00000212088.2 Gm45696 (from geneSymbol) AK134272 ENSMUST00000212088.1 uc291zvt.1 uc291zvt.2 uc291zvt.1 uc291zvt.2 
ENSMUST00000212103.3 Gm45740 ENSMUST00000212103.3 Gm45740 (from geneSymbol) EF591873 ENSMUST00000212103.1 ENSMUST00000212103.2 uc292bdf.1 uc292bdf.2 uc292bdf.3 uc292bdf.1 uc292bdf.2 uc292bdf.3 
ENSMUST00000212108.2 4930542C16Rik ENSMUST00000212108.2 4930542C16Rik (from geneSymbol) AK005833 ENSMUST00000212108.1 uc288roo.1 uc288roo.2 uc288roo.1 uc288roo.2 
ENSMUST00000212110.2 Gm45877 ENSMUST00000212110.2 Gm45877 (from geneSymbol) ENSMUST00000212110.1 uc292cqa.1 uc292cqa.2 uc292cqa.1 uc292cqa.2 
ENSMUST00000212114.2 Marcol ENSMUST00000212114.2 Marcol (from geneSymbol) A0A1D5RLC8 A0A1D5RLC8_MOUSE ENSMUST00000212114.1 Gm37797 Marcol uc289ozc.1 uc289ozc.2 uc289ozc.1 uc289ozc.2 
ENSMUST00000212119.2 Gm32122 ENSMUST00000212119.2 Gm32122 (from geneSymbol) AK134720 ENSMUST00000212119.1 uc292cmv.1 uc292cmv.2 uc292cmv.1 uc292cmv.2 
ENSMUST00000212127.3 Or7g23 ENSMUST00000212127.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1D5RMH6) A0A1D5RMH6 A0A1D5RMH6_MOUSE ENSMUST00000212127.1 ENSMUST00000212127.2 Olfr839 Or7g23 uc292eti.1 uc292eti.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292eti.1 uc292eti.2 
ENSMUST00000212135.2 Gm45723 ENSMUST00000212135.2 Gm45723 (from geneSymbol) ENSMUST00000212135.1 uc292dkv.1 uc292dkv.2 uc292dkv.1 uc292dkv.2 
ENSMUST00000212137.2 Gm45804 ENSMUST00000212137.2 Gm45804 (from geneSymbol) ENSMUST00000212137.1 uc292cee.1 uc292cee.2 uc292cee.1 uc292cee.2 
ENSMUST00000212156.3 Or8c17 ENSMUST00000212156.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1D5RM29) A0A1D5RM29 A0A1D5RM29_MOUSE ENSMUST00000212156.1 ENSMUST00000212156.2 Olfr895 Or8c17 uc292fxn.1 uc292fxn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fxn.1 uc292fxn.2 
ENSMUST00000212178.2 Gm45875 ENSMUST00000212178.2 Gm45875 (from geneSymbol) ENSMUST00000212178.1 uc292ecm.1 uc292ecm.2 uc292ecm.1 uc292ecm.2 
ENSMUST00000212181.2 Dock9 ENSMUST00000212181.2 dedicator of cytokinesis 9, transcript variant 5 (from RefSeq NM_001347596.1) A0A1D5RMM1 A0A1D5RMM1_MOUSE Dock9 ENSMUST00000212181.1 NM_001347596 uc007vah.1 uc007vah.2 uc007vah.3 uc007vah.4 Belongs to the DOCK family. guanyl-nucleotide exchange factor activity small GTPase mediated signal transduction uc007vah.1 uc007vah.2 uc007vah.3 uc007vah.4 
ENSMUST00000212188.2 Gm45890 ENSMUST00000212188.2 Gm45890 (from geneSymbol) AK013187 ENSMUST00000212188.1 uc009nwu.1 uc009nwu.2 uc009nwu.3 uc009nwu.1 uc009nwu.2 uc009nwu.3 
ENSMUST00000212189.2 Gm45779 ENSMUST00000212189.2 Gm45779 (from geneSymbol) AK154462 ENSMUST00000212189.1 uc292bad.1 uc292bad.2 uc292bad.1 uc292bad.2 
ENSMUST00000212190.2 Gm45760 ENSMUST00000212190.2 Gm45760 (from geneSymbol) AK015358 ENSMUST00000212190.1 uc292cmp.1 uc292cmp.2 uc292cmp.1 uc292cmp.2 
ENSMUST00000212196.2 Gm45899 ENSMUST00000212196.2 Gm45899 (from geneSymbol) AK139772 ENSMUST00000212196.1 uc292bcu.1 uc292bcu.2 uc292bcu.1 uc292bcu.2 
ENSMUST00000212197.2 Gm5485 ENSMUST00000212197.2 predicted gene 5485 (from RefSeq NR_015373.1) A0A1D5RM98 A0A1D5RM98_MOUSE ENSMUST00000212197.1 Gm5485 NR_015373 uc007zjo.1 uc007zjo.2 uc007zjo.1 uc007zjo.2 
ENSMUST00000212199.2 Gm45812 ENSMUST00000212199.2 Gm45812 (from geneSymbol) ENSMUST00000212199.1 uc292ciz.1 uc292ciz.2 uc292ciz.1 uc292ciz.2 
ENSMUST00000212203.2 Gm45747 ENSMUST00000212203.2 Gm45747 (from geneSymbol) ENSMUST00000212203.1 uc292dlz.1 uc292dlz.2 uc292dlz.1 uc292dlz.2 
ENSMUST00000212210.3 Gm45788 ENSMUST00000212210.3 Gm45788 (from geneSymbol) ENSMUST00000212210.1 ENSMUST00000212210.2 uc292cna.1 uc292cna.2 uc292cna.3 uc292cna.1 uc292cna.2 uc292cna.3 
ENSMUST00000212212.2 Rnf212 ENSMUST00000212212.2 ring finger protein 212 (from RefSeq NM_001362887.1) ENSMUST00000212212.1 F6TQD1 NM_001362887 Q8BN46 RN212_MOUSE uc290yak.1 uc290yak.2 SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination. Protein modification; protein sumoylation. Nucleus. Chromosome. Note=Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=F6TQD1-1; Sequence=Displayed; Name=2; IsoId=F6TQD1-2; Sequence=VSP_046302, VSP_046303; Specifically expressed in meiocytes of the gonads. In spermatocytes, first detected at the transition from leptonema to zygonema, localizing specifically to initial sites of homolog synapsis. The number of synaptonemal complex-associated Rnf212 increases as synapsis proceeds. Excluded from unsynapsed homolog. In early pachynema, as cells complete synapsis, detected as a punctate pattern of irregular foci along the synaptonemal complexes. Also localizes to the synapsed pseudoautosomal regions of the X-Y chromosomes. After early pachynema, protein levels strongly drop. By midpachynema, Rnf212 foci only remain at sites where crossovers form. Remaining foci disappear in late pachynema before the disassembly of synaptonemal complexes at diplonema and are not detected in early diplotene-stage cells in which homologs begin to desynapse. Pattern in fetal oocytes is very similar, except that the late-stage Rnf212 foci are still detected in nuclei in both the late-pachytene and early diplotene stages (at protein level). Both male and female mice are sterile. Males do not make sperm and have much smaller testes, a characteristic of mutants with meiotic defects. Testes show an absence of post-anaphase I cells, indicating loss of spermatocytes at this stage (stage XII seminiferous tubules). In females, ovary size is similar to that of wild-type animals, and high numbers of oocytes are present in mature animals. Complete synapsis is achieved but crossover complexes are absent. Rnf212 is haploinsufficient: although herozygous males are fertile and have wild-type sperm counts, they show significantly fewer Mlh1 foci and fewer chiasmata. Haploinsufficiency suggests that Rnf212 is a limiting factor for crossover designation and/or reinforcement. synaptonemal complex nucleus chromosome meiotic gene conversion synapsis reciprocal meiotic recombination transferase activity protein sumoylation SUMO transferase activity metal ion binding chiasma assembly meiotic cell cycle uc290yak.1 uc290yak.2 
ENSMUST00000212226.2 Gm45826 ENSMUST00000212226.2 Has antimicrobial activity against E.coli (By similarity). Plays a role in the defense response in the male reproductive tract, contributing to sperm maturation, storage and protection (By similarity). (from UniProt Q8K4N2) AY552529 Bin1b ENSMUST00000212226.1 Ep2 Ep2e Q2HPE4 Q30KM3 Q8K4N2 SG11A_MOUSE Spag11 Spag11a uc291yoa.1 uc291yoa.2 Has antimicrobial activity against E.coli (By similarity). Plays a role in the defense response in the male reproductive tract, contributing to sperm maturation, storage and protection (By similarity). Secreted Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Ep2q; IsoId=Q8K4N2-1; Sequence=Displayed; Name=2; IsoId=Q8K4N2-2; Sequence=VSP_020138; Belongs to the beta-defensin family. acrosomal vesicle molecular_function extracellular region defense response defense response to bacterium uc291yoa.1 uc291yoa.2 
ENSMUST00000212229.3 Or7g17 ENSMUST00000212229.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRH1) ENSMUST00000212229.1 ENSMUST00000212229.2 Olfr829 Or7g17 Q7TRH1 Q7TRH1_MOUSE uc292esx.1 uc292esx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292esx.1 uc292esx.2 
ENSMUST00000212236.2 Gm45824 ENSMUST00000212236.2 Gm45824 (from geneSymbol) BC039769 ENSMUST00000212236.1 uc291zup.1 uc291zup.2 uc291zup.1 uc291zup.2 
ENSMUST00000212238.2 Gm10280 ENSMUST00000212238.2 predicted gene 10280 (from RefSeq NR_033584.1) ENSMUST00000212238.1 NR_033584 uc009nnm.1 uc009nnm.2 uc009nnm.3 uc009nnm.1 uc009nnm.2 uc009nnm.3 
ENSMUST00000212248.2 Gm45895 ENSMUST00000212248.2 Gm45895 (from geneSymbol) ENSMUST00000212248.1 uc292cmr.1 uc292cmr.2 uc292cmr.1 uc292cmr.2 
ENSMUST00000212253.3 Gm39822 ENSMUST00000212253.3 Gm39822 (from geneSymbol) ENSMUST00000212253.1 ENSMUST00000212253.2 uc287xzx.1 uc287xzx.2 uc287xzx.3 uc287xzx.1 uc287xzx.2 uc287xzx.3 
ENSMUST00000212267.2 Gm45721 ENSMUST00000212267.2 Gm45721 (from geneSymbol) ENSMUST00000212267.1 uc292dkn.1 uc292dkn.2 uc292dkn.1 uc292dkn.2 
ENSMUST00000212286.3 Gm33460 ENSMUST00000212286.3 Gm33460 (from geneSymbol) ENSMUST00000212286.1 ENSMUST00000212286.2 uc292man.1 uc292man.2 uc292man.3 uc292man.1 uc292man.2 uc292man.3 
ENSMUST00000212287.3 Efcab3 ENSMUST00000212287.3 EF-hand calcium binding domain 3, transcript variant 1 (from RefSeq NM_001271338.1) A0A1D5RLM8 A0A1D5RLM8_MOUSE ENSMUST00000212287.1 ENSMUST00000212287.2 Gm11639 NM_001271338 uc288cwi.1 uc288cwi.2 uc288cwi.3 molecular_function calcium ion binding biological_process uc288cwi.1 uc288cwi.2 uc288cwi.3 
ENSMUST00000212293.3 Gm45703 ENSMUST00000212293.3 Gm45703 (from geneSymbol) ENSMUST00000212293.1 ENSMUST00000212293.2 uc292cmy.1 uc292cmy.2 uc292cmy.3 uc292cmy.1 uc292cmy.2 uc292cmy.3 
ENSMUST00000212303.2 Zdhhc1 ENSMUST00000212303.2 zinc finger, DHHC domain containing 1, transcript variant 11 (from RefSeq NR_166409.1) ENSMUST00000212303.1 NR_166409 Q0VE36 Q8BJ24 Q8R0N9 ZDHC1_MOUSE Zdhhc1 uc009ndd.1 uc009ndd.2 uc009ndd.3 Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:23687301). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (PubMed:23687301). Has also a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response (PubMed:25299331). Functions as an activator of STING1 by promoting its cGAMP-induced oligomerization and the recruitment of downstream signaling components (PubMed:25299331). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Interacts with STING1; ZDHHC1 constitutively interacts with STING1 and in presence of DNA viruses activates it by promoting its cGAMP-induced oligomerization and the recruitment of downstream signaling components. Endosome membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus Expressed at high levels in fetal lung and heart. Expressed at lower levels in fetal liver and brain. Also detected in adult islet cells of pancreas, Leydig cells of testis, retina and molecular layer of cerebellum. The DHHC domain is required for palmitoyltransferase activity. Homozygous knockout mice are viable, fertile and do not display overt phenotype (PubMed:25299331). Composition and number of major immune cells is normal but mice are more susceptible to DNA-virus infection and death than their wild-type counterpart (PubMed:25299331). Belongs to the DHHC palmitoyltransferase family. endoplasmic reticulum Golgi apparatus protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity uc009ndd.1 uc009ndd.2 uc009ndd.3 
ENSMUST00000212310.2 Gm45853 ENSMUST00000212310.2 Gm45853 (from geneSymbol) AK084674 ENSMUST00000212310.1 uc292ckl.1 uc292ckl.2 uc292ckl.1 uc292ckl.2 
ENSMUST00000212313.2 Gm36879 ENSMUST00000212313.2 predicted gene, 36879 (from RefSeq NR_188749.1) ENSMUST00000212313.1 NR_188749 uc291yqw.1 uc291yqw.2 uc291yqw.1 uc291yqw.2 
ENSMUST00000212317.2 Gm45843 ENSMUST00000212317.2 Gm45843 (from geneSymbol) ENSMUST00000212317.1 uc292crb.1 uc292crb.2 uc292crb.1 uc292crb.2 
ENSMUST00000212339.2 6030466F02Rik ENSMUST00000212339.2 RIKEN cDNA 6030466F02 gene (from RefSeq NR_040702.1) ENSMUST00000212339.1 NR_040702 uc029wwv.1 uc029wwv.2 uc029wwv.1 uc029wwv.2 
ENSMUST00000212355.2 Zfp853 ENSMUST00000212355.2 zinc finger protein 853 (from RefSeq NM_001370826.1) A0A1D5RM95 A0A1D5RM95_MOUSE ENSMUST00000212355.1 NM_001370826 Zfp853 uc291bmf.1 uc291bmf.2 negative regulation of transcription from RNA polymerase II promoter nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleoplasm transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter uc291bmf.1 uc291bmf.2 
ENSMUST00000212360.2 ENSMUSG00000121660 ENSMUST00000212360.2 ENSMUSG00000121660 (from geneSymbol) ENSMUST00000212360.1 uc291yog.1 uc291yog.2 uc291yog.1 uc291yog.2 
ENSMUST00000212362.2 Msantd1 ENSMUST00000212362.2 Msantd1 (from geneSymbol) A0A1D5RLV8 A0A1D5RLV8_MOUSE BC116928 ENSMUST00000212362.1 Msantd1 uc290utb.1 uc290utb.2 uc290utb.1 uc290utb.2 
ENSMUST00000212366.2 Gm45776 ENSMUST00000212366.2 Gm45776 (from geneSymbol) AK033700 ENSMUST00000212366.1 uc292dka.1 uc292dka.2 uc292dka.1 uc292dka.2 
ENSMUST00000212384.3 6330537M06Rik ENSMUST00000212384.3 6330537M06Rik (from geneSymbol) ENSMUST00000212384.1 ENSMUST00000212384.2 uc292arz.1 uc292arz.2 uc292arz.3 uc292arz.1 uc292arz.2 uc292arz.3 
ENSMUST00000212387.3 Gm20735 ENSMUST00000212387.3 Gm20735 (from geneSymbol) AK042436 ENSMUST00000212387.1 ENSMUST00000212387.2 uc029wwq.1 uc029wwq.2 uc029wwq.3 uc029wwq.4 uc029wwq.1 uc029wwq.2 uc029wwq.3 uc029wwq.4 
ENSMUST00000212394.2 Iqca1 ENSMUST00000212394.2 Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. (from UniProt Q9CUL5) AK139726 DRC11_MOUSE Drc11 ENSMUST00000212394.1 Iqca Q3UT65 Q9CUL5 Q9D4P1 uc287khk.1 uc287khk.2 Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Component of the nexin-dynein regulatory complex (N-DRC). Cytoplasm, cytoskeleton, flagellum axoneme Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9CUL5-1; Sequence=Displayed; Name=2; IsoId=Q9CUL5-2; Sequence=VSP_024334, VSP_024335; Name=3; IsoId=Q9CUL5-3; Sequence=VSP_024333, VSP_024336, VSP_024337; Belongs to the AAA ATPase family. DRC11 subfamily. nucleotide binding molecular_function ATP binding cytoplasm cytoskeleton cilium biological_process motile cilium cell projection uc287khk.1 uc287khk.2 
ENSMUST00000212396.2 Dnmbp ENSMUST00000212396.2 dynamin binding protein, transcript variant 1 (from RefSeq NM_028029.5) A0A0R4J055 A0A0R4J055_MOUSE Dnmbp ENSMUST00000212396.1 NM_028029 uc033hkq.1 uc033hkq.2 uc033hkq.3 uc033hkq.4 This gene encodes a member of the DBL family of guanine nucleotide exchange factors. The encoded protein has been proposed to regulate the actin cytoskeleton by specifically activating the Rho-family GTPase Cdc42. An interaction between the encoded protein and a Listeria protein has been shown to mediate Listeria infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Cell junction Cytoplasm, cytoskeleton Golgi apparatus, Golgi stack Synapse guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cytoplasm Golgi apparatus cell-cell junction aging regulation of cell shape regulation of Rho protein signal transduction intracellular signal transduction synapse presynapse uc033hkq.1 uc033hkq.2 uc033hkq.3 uc033hkq.4 
ENSMUST00000212411.2 Gm4316 ENSMUST00000212411.2 Gm4316 (from geneSymbol) ENSMUST00000212411.1 uc292dvp.1 uc292dvp.2 uc292dvp.1 uc292dvp.2 
ENSMUST00000212413.2 Gm45909 ENSMUST00000212413.2 Gm45909 (from geneSymbol) AK053235 ENSMUST00000212413.1 uc292cbx.1 uc292cbx.2 uc292cbx.1 uc292cbx.2 
ENSMUST00000212419.2 4930422C21Rik ENSMUST00000212419.2 4930422C21Rik (from geneSymbol) AK015175 ENSMUST00000212419.1 uc292djb.1 uc292djb.2 uc292djb.1 uc292djb.2 
ENSMUST00000212425.3 Gm45866 ENSMUST00000212425.3 Gm45866 (from geneSymbol) ENSMUST00000212425.1 ENSMUST00000212425.2 uc292dzl.1 uc292dzl.2 uc292dzl.3 uc292dzl.1 uc292dzl.2 uc292dzl.3 
ENSMUST00000212427.2 Gm35572 ENSMUST00000212427.2 Gm35572 (from geneSymbol) AK142664 ENSMUST00000212427.1 uc009mew.1 uc009mew.2 uc009mew.1 uc009mew.2 
ENSMUST00000212436.2 Iqcn ENSMUST00000212436.2 IQ motif containing N, transcript variant 2 (from RefSeq NM_001370847.1) A0A9L6JPS2 A0A9L6JPS2_MOUSE ENSMUST00000212436.1 Iqcn NM_001370847 uc292arl.1 uc292arl.2 uc292arl.1 uc292arl.2 
ENSMUST00000212448.2 Gm45758 ENSMUST00000212448.2 Gm45758 (from geneSymbol) AK144425 ENSMUST00000212448.1 uc292ciq.1 uc292ciq.2 uc292ciq.1 uc292ciq.2 
ENSMUST00000212459.2 Large1 ENSMUST00000212459.2 LARGE xylosyl- and glucuronyltransferase 1, transcript variant 1 (from RefSeq NM_001317391.2) ENSMUST00000212459.1 Kiaa0609 LARG1_MOUSE Large Large1 NM_001317391 Q497S9 Q6P7U2 Q80TW0 Q9Z1M7 uc012gga.1 uc012gga.2 uc012gga.3 uc012gga.4 Bifunctional glycosyltransferase with both alpha-1,3- xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain- containing extracellular proteins with high affinity (PubMed:23125099, PubMed:23135544, PubMed:25138275, PubMed:32975514). Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity). Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer (PubMed:32975514). Plays a key role in skeletal muscle function and regeneration (PubMed:15184894, PubMed:24132234). Reaction=3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3- beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr- [protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA- (1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)- beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP; Xref=Rhea:RHEA:57336, Rhea:RHEA-COMP:17482, Rhea:RHEA-COMP:17483, ChEBI:CHEBI:15378, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:177336, ChEBI:CHEBI:177352; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57337; Evidence=; Reaction=3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta- D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc- (1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)- beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D- GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP; Xref=Rhea:RHEA:67924, Rhea:RHEA-COMP:17484, Rhea:RHEA-COMP:17486, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:177354, ChEBI:CHEBI:177355; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67925; Evidence=; Reaction=3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA- (1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc- (1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP- alpha-D-xylose = 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA- (1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc- (1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP; Xref=Rhea:RHEA:68368, Rhea:RHEA-COMP:17485, Rhea:RHEA- COMP:17486, ChEBI:CHEBI:15378, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:177354, ChEBI:CHEBI:177355; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68369; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 Mn(2+) ions per subunit. The xylosyltransferase part binds one Mn(2+) and the beta-1,3-glucuronyltransferase part binds one Mn(2+). ; Protein modification; protein glycosylation. Interacts with DAG1 (via the N-terminal domain of alpha-DAG1); the interaction increases binding of DAG1 to laminin (PubMed:15210115). Interacts with B4GAT1. Golgi apparatus membrane ; Single-pass type II membrane protein Ubiquitous. Highest expression in heart, diaphragm and brain, where it is especially found in cerebral cortex, hippocampus, and trigeminal ganglion. Ubiquitously found at 14.5 dpc with strong expression in heart, central nervous system structures such as cerebral cortex, hippocampus, olfactory lobe, trigeminal ganglion and spinal cord. Also expressed in diaphragm and duodenum. Note=Defects in Large are the cause of myodystrophy (myd), an autosomal recessive neuromuscular phenotype, probably due to abnormal post-translational modification of alpha-dystroglycan. In the C-terminal section; belongs to the glycosyltransferase 49 family. In the N-terminal section; belongs to the glycosyltransferase 8 family. Sequence=AAH61506.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC65610.1; Type=Frameshift; Evidence=; Name=Functional Glycomics Gateway - GTase; Note=Large like-glycosyltransferase; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_589"; Golgi membrane catalytic activity protein binding Golgi apparatus protein glycosylation metabolic process glycoprotein biosynthetic process glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups manganese ion binding protein O-linked mannosylation xylosyltransferase activity intracellular membrane-bounded organelle skeletal muscle tissue regeneration muscle cell cellular homeostasis metal ion binding skeletal muscle organ development uc012gga.1 uc012gga.2 uc012gga.3 uc012gga.4 
ENSMUST00000212460.2 Gm45732 ENSMUST00000212460.2 Gm45732 (from geneSymbol) ENSMUST00000212460.1 uc292eab.1 uc292eab.2 uc292eab.1 uc292eab.2 
ENSMUST00000212465.3 Gm32352 ENSMUST00000212465.3 Gm32352 (from geneSymbol) AK085792 ENSMUST00000212465.1 ENSMUST00000212465.2 uc009nqc.1 uc009nqc.2 uc009nqc.3 uc009nqc.1 uc009nqc.2 uc009nqc.3 
ENSMUST00000212466.2 Gm45829 ENSMUST00000212466.2 Gm45829 (from geneSymbol) ENSMUST00000212466.1 uc291zvl.1 uc291zvl.2 uc291zvl.1 uc291zvl.2 
ENSMUST00000212489.3 Or8b35 ENSMUST00000212489.3 Membrane ; Multi- pass membrane protein (from UniProt Q7TRE2) ENSMUST00000212489.1 ENSMUST00000212489.2 Olfr881 Or8b35 Q7TRE2 Q7TRE2_MOUSE uc292fwx.1 uc292fwx.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fwx.1 uc292fwx.2 
ENSMUST00000212495.2 4932416K20Rik ENSMUST00000212495.2 4932416K20Rik (from geneSymbol) ENSMUST00000212495.1 uc292csh.1 uc292csh.2 uc292csh.1 uc292csh.2 
ENSMUST00000212502.4 Or8b39 ENSMUST00000212502.4 Membrane ; Multi- pass membrane protein (from UniProt Q9EQA6) ENSMUST00000212502.1 ENSMUST00000212502.2 ENSMUST00000212502.3 Olfr887 Or8b39 Q9EQA6 Q9EQA6_MOUSE uc292fxc.1 uc292fxc.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fxc.1 uc292fxc.2 
ENSMUST00000212520.2 Capn15 ENSMUST00000212520.2 calpain 15, transcript variant 9 (from RefSeq NR_182226.1) A0A1D5RLS3 A0A1D5RLS3_MOUSE Capn15 ENSMUST00000212520.1 NR_182226 uc008bda.1 uc008bda.2 uc008bda.3 Belongs to the peptidase C2 family. calcium-dependent cysteine-type endopeptidase activity proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity metal ion binding uc008bda.1 uc008bda.2 uc008bda.3 
ENSMUST00000212524.2 Sntb2 ENSMUST00000212524.2 syntrophin, basic 2, transcript variant 2 (from RefSeq NM_009229.5) ENSMUST00000212524.1 NM_009229 Q61235 SNTB2_MOUSE Snt2b2 uc009ngt.1 uc009ngt.2 uc009ngt.3 Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN (By similarity). Monomer and homodimer (Probable). Interacts with the dystrophin protein DMD and related protein DTNA; and with the other members of the syntrophin family: SNTA1 and SNTB1. Interacts with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN (By similarity). Interacts with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins. Interacts with the dystrophin related protein UTRN. Interacts with DTNB (PubMed:10893187). Membrane Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein Cell junction Cytoplasm, cytoskeleton Note=Membrane-associated. In insulinoma cell line, it is enriched in secretory granules (By similarity). In muscle, it is exclusively localized at the neuromuscular junction. Ubiquitous. Expressed at high levels in the testis. The PH 1 domain mediates the oligomerization in a calcium dependent manner. The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity). The SU domain binds calmodulin in a calcium-dependent manner. Phosphorylated. Partially dephosphorylated upon insulin stimulation (By similarity). Belongs to the syntrophin family. actin binding structural molecule activity protein binding calmodulin binding cytoplasm cytoskeleton microtubule dystrophin-associated glycoprotein complex membrane cell junction transport vesicle membrane cytoplasmic vesicle macromolecular complex synapse uc009ngt.1 uc009ngt.2 uc009ngt.3 
ENSMUST00000212540.3 Or7e168 ENSMUST00000212540.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRF5) ENSMUST00000212540.1 ENSMUST00000212540.2 Olfr859 Or7e168 Q7TRF5 Q7TRF5_MOUSE uc292eum.1 uc292eum.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292eum.1 uc292eum.2 
ENSMUST00000212549.2 Zfp781a ENSMUST00000212549.2 RIKEN cDNA D130040H23 gene, transcript variant 1 (from RefSeq NM_001384124.1) A0A1D5RLK0 A0A1D5RLK0_MOUSE D130040H23Rik ENSMUST00000212549.1 NM_001384124 uc009lxd.1 uc009lxd.2 uc009lxd.3 molecular_function nucleic acid binding cellular_component biological_process uc009lxd.1 uc009lxd.2 uc009lxd.3 
ENSMUST00000212599.3 Gm26953 ENSMUST00000212599.3 Gm26953 (from geneSymbol) ENSMUST00000212599.1 ENSMUST00000212599.2 uc290yih.1 uc290yih.2 uc290yih.3 uc290yih.1 uc290yih.2 uc290yih.3 
ENSMUST00000212602.3 4933406B17Rik ENSMUST00000212602.3 4933406B17Rik (from geneSymbol) AK016680 ENSMUST00000212602.1 ENSMUST00000212602.2 uc292ckm.1 uc292ckm.2 uc292ckm.3 uc292ckm.1 uc292ckm.2 uc292ckm.3 
ENSMUST00000212611.2 Kcnn1 ENSMUST00000212611.2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1, transcript variant 1 (from RefSeq NM_001363407.2) A0A140T8Q8 A0A140T8Q8_MOUSE ENSMUST00000212611.1 Kcnn1 NM_001363407 uc009mbx.1 uc009mbx.2 uc009mbx.3 uc009mbx.4 Membrane ; Multi- pass membrane protein calmodulin binding potassium ion transport calcium-activated potassium channel activity membrane integral component of membrane small conductance calcium-activated potassium channel activity neuronal cell body protein heterodimerization activity potassium ion transmembrane transport uc009mbx.1 uc009mbx.2 uc009mbx.3 uc009mbx.4 
ENSMUST00000212621.2 Gm39139 ENSMUST00000212621.2 Gm39139 (from geneSymbol) AK133159 ENSMUST00000212621.1 uc291yod.1 uc291yod.2 uc291yod.1 uc291yod.2 
ENSMUST00000212623.2 Gm45746 ENSMUST00000212623.2 Gm45746 (from geneSymbol) ENSMUST00000212623.1 uc292eec.1 uc292eec.2 uc292eec.1 uc292eec.2 
ENSMUST00000212627.2 Gm45892 ENSMUST00000212627.2 Gm45892 (from geneSymbol) ENSMUST00000212627.1 uc292cow.1 uc292cow.2 uc292cow.1 uc292cow.2 
ENSMUST00000212635.3 5033426O07Rik ENSMUST00000212635.3 5033426O07Rik (from geneSymbol) AK017196 ENSMUST00000212635.1 ENSMUST00000212635.2 uc292dpp.1 uc292dpp.2 uc292dpp.3 uc292dpp.1 uc292dpp.2 uc292dpp.3 
ENSMUST00000212657.2 Il12rb1 ENSMUST00000212657.2 Il12rb1 (from geneSymbol) A0A1D5RL98 A0A1D5RL98_MOUSE AK137577 ENSMUST00000212657.1 Il12rb1 uc292asp.1 uc292asp.2 uc292asp.1 uc292asp.2 
ENSMUST00000212661.2 1700093P08Rik ENSMUST00000212661.2 1700093P08Rik (from geneSymbol) AK007055 ENSMUST00000212661.1 uc292bdg.1 uc292bdg.2 uc292bdg.1 uc292bdg.2 
ENSMUST00000212672.2 Gm45887 ENSMUST00000212672.2 Gm45887 (from geneSymbol) AK141781 ENSMUST00000212672.1 uc292cox.1 uc292cox.2 uc292cox.1 uc292cox.2 
ENSMUST00000212679.3 Gm45897 ENSMUST00000212679.3 Gm45897 (from geneSymbol) ENSMUST00000212679.1 ENSMUST00000212679.2 uc292maz.1 uc292maz.2 uc292maz.3 uc292maz.1 uc292maz.2 uc292maz.3 
ENSMUST00000212681.2 Zfp930 ENSMUST00000212681.2 zinc finger protein 930, transcript variant 1 (from RefSeq NM_001013379.3) A0A1D5RM15 A0A1D5RM15_MOUSE ENSMUST00000212681.1 NM_001013379 Zfp930 uc009lxc.1 uc009lxc.2 uc009lxc.3 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc009lxc.1 uc009lxc.2 uc009lxc.3 
ENSMUST00000212698.2 Gm45876 ENSMUST00000212698.2 Gm45876 (from geneSymbol) ENSMUST00000212698.1 uc292ecn.1 uc292ecn.2 uc292ecn.1 uc292ecn.2 
ENSMUST00000212701.2 Gm45743 ENSMUST00000212701.2 Gm45743 (from geneSymbol) AK158676 ENSMUST00000212701.1 uc292dug.1 uc292dug.2 uc292dug.1 uc292dug.2 
ENSMUST00000212714.2 Gm45823 ENSMUST00000212714.2 Gm45823 (from geneSymbol) ENSMUST00000212714.1 uc292bkr.1 uc292bkr.2 uc292bkr.1 uc292bkr.2 
ENSMUST00000212725.2 Fbxw27 ENSMUST00000212725.2 F-box and WD-40 domain protein 27, transcript variant 1 (from RefSeq NM_001303003.1) A0A1D5RLF0 A0A1D5RLF0_MOUSE ENSMUST00000212725.1 Fbxw27 NM_001303003 uc292lnc.1 uc292lnc.2 molecular_function cellular_component biological_process uc292lnc.1 uc292lnc.2 
ENSMUST00000212728.3 Gm45894 ENSMUST00000212728.3 Gm45894 (from geneSymbol) AK040202 ENSMUST00000212728.1 ENSMUST00000212728.2 uc009ntw.1 uc009ntw.2 uc009ntw.3 uc009ntw.4 uc009ntw.1 uc009ntw.2 uc009ntw.3 uc009ntw.4 
ENSMUST00000212738.2 Gm45817 ENSMUST00000212738.2 Gm45817 (from geneSymbol) ENSMUST00000212738.1 uc291zgi.1 uc291zgi.2 uc291zgi.1 uc291zgi.2 
ENSMUST00000212751.2 Gm29773 ENSMUST00000212751.2 Gm29773 (from geneSymbol) AK140795 ENSMUST00000212751.1 uc292dzs.1 uc292dzs.2 uc292dzs.1 uc292dzs.2 
ENSMUST00000212754.2 Zfp612 ENSMUST00000212754.2 zinc finger protein 612 (from RefSeq NM_175480.4) A0A1D5RMC2 A0A1D5RMC2_MOUSE ENSMUST00000212754.1 NM_175480 Zfp612 uc009njv.1 uc009njv.2 uc009njv.3 uc009njv.4 nucleic acid binding cellular_component regulation of transcription, DNA-templated metal ion binding uc009njv.1 uc009njv.2 uc009njv.3 uc009njv.4 
ENSMUST00000212759.2 Gm45797 ENSMUST00000212759.2 Gm45797 (from geneSymbol) AK039542 ENSMUST00000212759.1 uc292cfx.1 uc292cfx.2 uc292cfx.1 uc292cfx.2 
ENSMUST00000212762.2 Gm45832 ENSMUST00000212762.2 Gm45832 (from geneSymbol) AK032925 ENSMUST00000212762.1 uc291zvm.1 uc291zvm.2 uc291zvm.1 uc291zvm.2 
ENSMUST00000212774.2 ENSMUSG00000121421 ENSMUST00000212774.2 ENSMUSG00000121421 (from geneSymbol) ENSMUST00000212774.1 uc292cry.1 uc292cry.2 uc292cry.1 uc292cry.2 
ENSMUST00000212778.2 Gm45767 ENSMUST00000212778.2 Gm45767 (from geneSymbol) ENSMUST00000212778.1 LF197157 uc292cge.1 uc292cge.2 uc292cge.1 uc292cge.2 
ENSMUST00000212780.2 Gm35256 ENSMUST00000212780.2 Gm35256 (from geneSymbol) AK029875 ENSMUST00000212780.1 uc009mcf.1 uc009mcf.2 uc009mcf.3 uc009mcf.1 uc009mcf.2 uc009mcf.3 
ENSMUST00000212782.2 Gm32568 ENSMUST00000212782.2 predicted gene, 32568 (from RefSeq NR_188774.1) ENSMUST00000212782.1 NR_188774 uc292ahl.1 uc292ahl.2 uc292ahl.1 uc292ahl.2 
ENSMUST00000212785.2 Gm45708 ENSMUST00000212785.2 Gm45708 (from geneSymbol) AK080595 ENSMUST00000212785.1 uc292ccr.1 uc292ccr.2 uc292ccr.1 uc292ccr.2 
ENSMUST00000212798.2 Mroh3 ENSMUST00000212798.2 maestro heat-like repeat family member 3 (from RefSeq NM_001329610.2) A0A1D5RM54 A0A1D5RM54_MOUSE ENSMUST00000212798.1 Mroh3 NM_001329610 uc287mca.1 uc287mca.2 molecular_function cellular_component biological_process uc287mca.1 uc287mca.2 
ENSMUST00000212800.2 C78859 ENSMUST00000212800.2 C78859 (from geneSymbol) ENSMUST00000212800.1 LF197149 uc292ceg.1 uc292ceg.2 uc292ceg.1 uc292ceg.2 
ENSMUST00000212804.2 Gimd1 ENSMUST00000212804.2 GIMAP family P-loop NTPase domain containing 1, transcript variant 1 (from RefSeq NM_001372140.1) E9PW74 ENSMUST00000212804.1 GIMD1_MOUSE Gm5549 NM_001372140 uc290jts.1 uc290jts.2 Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. nucleotide binding GTP binding cellular_component biological_process uc290jts.1 uc290jts.2 
ENSMUST00000212816.2 Gm30132 ENSMUST00000212816.2 Gm30132 (from geneSymbol) ENSMUST00000212816.1 uc009mvc.1 uc009mvc.2 uc009mvc.3 uc009mvc.4 uc009mvc.1 uc009mvc.2 uc009mvc.3 uc009mvc.4 
ENSMUST00000212824.2 Nup93 ENSMUST00000212824.2 nucleoporin 93, transcript variant 1 (from RefSeq NM_172410.4) Cip4 ENSMUST00000212824.1 Kiaa0095 NM_172410 NUP93_MOUSE Q3TED9 Q8BIK7 Q8BJ71 Q8K1R4 Q8R592 uc009mvz.1 uc009mvz.2 Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC (By similarity). During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (By similarity) (PubMed:26878725). Part of the nuclear pore complex (NPC). Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP35, NUP155, NUP205 and lamin B; the interaction with NUP35 is direct. Does not interact with TPR. Interacts with SMAD4 and IPO7; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling. Nucleus membrane ; Peripheral membrane protein Nucleus, nuclear pore complex Nucleus envelope Note=Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BJ71-1; Sequence=Displayed; Name=2; IsoId=Q8BJ71-2; Sequence=VSP_010089; Belongs to the nucleoporin interacting component (NIC) family. Sequence=BAC97865.2; Type=Frameshift; Evidence=; nucleus nuclear envelope nuclear pore protein import into nucleus nuclear envelope organization protein transport membrane poly(A)+ mRNA export from nucleus structural constituent of nuclear pore nuclear membrane nuclear periphery mRNA transport nuclear pore complex assembly positive regulation of SMAD protein import into nucleus SMAD protein signal transduction renal system development uc009mvz.1 uc009mvz.2 
ENSMUST00000212838.3 Gm45699 ENSMUST00000212838.3 Gm45699 (from geneSymbol) AK132735 ENSMUST00000212838.1 ENSMUST00000212838.2 uc292euo.1 uc292euo.2 uc292euo.3 uc292euo.1 uc292euo.2 uc292euo.3 
ENSMUST00000212860.2 Gm45781 ENSMUST00000212860.2 Gm45781 (from geneSymbol) ENSMUST00000212860.1 uc292dzk.1 uc292dzk.2 uc292dzk.1 uc292dzk.2 
ENSMUST00000212863.2 Gm45762 ENSMUST00000212863.2 Gm45762 (from geneSymbol) ENSMUST00000212863.1 uc292cmd.1 uc292cmd.2 uc292cmd.1 uc292cmd.2 
ENSMUST00000212864.2 Gapdhrt2 ENSMUST00000212864.2 Reaction=D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3- phospho-glyceroyl phosphate + H(+) + NADH; Xref=Rhea:RHEA:10300, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57540, ChEBI:CHEBI:57604, ChEBI:CHEBI:57945, ChEBI:CHEBI:59776; EC=1.2.1.12; Evidence= (from UniProt A0A1D5RLD8) A0A1D5RLD8 A0A1D5RLD8_MOUSE ENSMUST00000212864.1 Gapdhrt2 Gm10358 LF197043 uc292bdc.1 uc292bdc.2 Reaction=D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3- phospho-glyceroyl phosphate + H(+) + NADH; Xref=Rhea:RHEA:10300, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57540, ChEBI:CHEBI:57604, ChEBI:CHEBI:57945, ChEBI:CHEBI:59776; EC=1.2.1.12; Evidence= Reaction=L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] = L- cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]; Xref=Rhea:RHEA:66684, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:17089, Rhea:RHEA-COMP:17090, Rhea:RHEA-COMP:17091, ChEBI:CHEBI:29950, ChEBI:CHEBI:149494; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66685; Evidence=; Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 1/5. Homotetramer. Cytoplasm, cytoskeleton Cytoplasm, cytosol Nucleus Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. nucleotide binding glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity cytosol glucose metabolic process glycolytic process oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor NADP binding NAD binding oxidation-reduction process uc292bdc.1 uc292bdc.2 
ENSMUST00000212865.2 Gm10286 ENSMUST00000212865.2 Gm10286 (from geneSymbol) ENSMUST00000212865.1 LF197163 uc292chr.1 uc292chr.2 uc292chr.1 uc292chr.2 
ENSMUST00000212885.3 ENSMUSG00000121369 ENSMUST00000212885.3 ENSMUSG00000121369 (from geneSymbol) ENSMUST00000212885.1 ENSMUST00000212885.2 uc287ndp.1 uc287ndp.2 uc287ndp.3 uc287ndp.1 uc287ndp.2 uc287ndp.3 
ENSMUST00000212889.2 Slc27a1 ENSMUST00000212889.2 solute carrier family 27 (fatty acid transporter), member 1, transcript variant 4 (from RefSeq NM_001357182.1) ENSMUST00000212889.1 Fatp Fatp1 NM_001357182 Q60714 S27A1_MOUSE Slc27a1 uc009mdx.1 uc009mdx.2 uc009mdx.3 Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:7954810, PubMed:9786857, PubMed:9671728, PubMed:10471110, PubMed:12235169, PubMed:11970897, PubMed:15699031, PubMed:28178239, PubMed:24858472, PubMed:19527715) (Probable). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl- CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:10593920, PubMed:12235169, PubMed:12937175). May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation (PubMed:14991074, PubMed:15897321). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:12235169). May be involved in regulation of cholesterol metabolism (PubMed:12235169). Probably involved in fatty acid transport across the blood barrier (By similarity). Reaction=a fatty acid(in) = a fatty acid(out); Xref=Rhea:RHEA:38879, ChEBI:CHEBI:28868; Evidence= Reaction=(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in); Xref=Rhea:RHEA:33655, ChEBI:CHEBI:30823; Evidence=; Reaction=hexadecanoate(out) = hexadecanoate(in); Xref=Rhea:RHEA:45256, ChEBI:CHEBI:7896; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) = (5Z,8Z,11Z,14Z)- eicosatetraenoate(in); Xref=Rhea:RHEA:71395, ChEBI:CHEBI:32395; Evidence=; Reaction=(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)- octadecadienoate(in); Xref=Rhea:RHEA:45264, ChEBI:CHEBI:30245; Evidence=; Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl- CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:456215; EC=6.2.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19714; Evidence=; Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537; Evidence=; Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616, ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:456215; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640; Evidence=; Inhibited by Triacsin C (PubMed:12235169). Both insulin and muscle contraction stimulate translocation to the plasma membrane in muscle, increasing fatty acid transport activity (PubMed:19527715). Kinetic parameters: KM=0.2 uM for (9Z)-octadecenoate (oleate) ; Self-associates. May function as a homodimer (PubMed:12533547). Interacts with EPRS1; mediates the translocation of SLC27A1 from the cytoplasm to the plasma membrane thereby increasing the uptake of long-chain fatty acids (PubMed:28178239). Interacts with DGAT2 and this interaction is enhanced in the presence of ZFYVE1 (By similarity). Cell membrane ingle-pass membrane protein Mitochondrion outer membrane Endomembrane system ingle-pass membrane protein Cytoplasm Note=Plasma membrane and intracellular membranes, at least in adipocytes (PubMed:10593920, PubMed:11970897, PubMed:28178239). In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake (PubMed:11970897, PubMed:28178239). Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1 (PubMed:11970897, PubMed:28178239). Predominantly cytoplasmic in myocytes (PubMed:15897321). Higher expression in white adipose tissue than in heart (PubMed:12556534). Highest expression in skeletal muscle, heart and fat. Lower levels in brain, kidney, lung, liver and testis. No expression in spleen or intestine. Higher expression in differentiated adipocytes compared to preadipocytes. Expression is down-regulated by insulin. Mice deficient for Slc27a1 are viable and do not display overt developmental phenotype or alteration in whole-body adiposity. However, they are protected from fat-induced accumulation of intramuscular fatty acyl-CoA and insulin resistance in skeletal muscle. Belongs to the ATP-dependent AMP-binding enzyme family. nucleotide binding medium-chain fatty acid transport long-chain fatty acid metabolic process catalytic activity long-chain fatty acid-CoA ligase activity long-chain fatty acid transporter activity protein binding cytoplasm mitochondrion endoplasmic reticulum cytosol plasma membrane integral component of plasma membrane caveola lipid metabolic process fatty acid metabolic process phosphatidylethanolamine biosynthetic process phosphatidic acid biosynthetic process phosphatidylglycerol biosynthetic process phosphatidylcholine biosynthetic process phosphatidylserine biosynthetic process phosphatidylinositol biosynthetic process lipid transport response to cold positive regulation of triglyceride biosynthetic process endomembrane system fatty acid transporter activity fatty acid transport long-chain fatty acid transport membrane integral component of membrane ligase activity cytoplasmic vesicle positive regulation of heat generation very long-chain fatty acid-CoA ligase activity cardiolipin biosynthetic process response to insulin adiponectin-activated signaling pathway protein homodimerization activity intracellular membrane-bounded organelle long-chain fatty acid import negative regulation of phospholipid biosynthetic process positive regulation of protein serine/threonine kinase activity mitochondrial inner membrane uc009mdx.1 uc009mdx.2 uc009mdx.3 
ENSMUST00000212891.2 Gm45903 ENSMUST00000212891.2 Gm45903 (from geneSymbol) ENSMUST00000212891.1 uc292bcv.1 uc292bcv.2 uc292bcv.1 uc292bcv.2 
ENSMUST00000212893.2 Gm45697 ENSMUST00000212893.2 Gm45697 (from geneSymbol) ENSMUST00000212893.1 uc291zvs.1 uc291zvs.2 uc291zvs.1 uc291zvs.2 
ENSMUST00000212899.2 Gm42047 ENSMUST00000212899.2 Gm42047 (from geneSymbol) BC062922 ENSMUST00000212899.1 uc292drc.1 uc292drc.2 uc292drc.1 uc292drc.2 
ENSMUST00000212902.2 Cfap54 ENSMUST00000212902.2 cilia and flagella associated protein 54 (from RefSeq NM_001347060.2) A0A0K0NTX9 CFA54_MOUSE Cfap54 D3Z3Q2 E9PUV7 ENSMUST00000212902.1 NM_001347060 Q8C6S9 uc007guh.1 uc007guh.2 uc007guh.3 uc007guh.4 Required for assembly and function of cilia and flagella (PubMed:26224312). Cytoplasm, cytoskeleton, cilium axoneme Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8C6S9-1; Sequence=Displayed; Name=2; IsoId=Q8C6S9-2; Sequence=VSP_058120; Expressed at high level in the testis and at a low level in the lung and brain. Deficient mice shown hydrocephalus, male infertility, and accumulation of mucus in the sinus cavity. The male infertility is due to severe defects in spermatid flagellar formation. Belongs to the CFAP54 family. molecular_function cytoplasm cytoskeleton cilium axoneme spermatogenesis cell projection organization cell differentiation cell projection cilium assembly cilium movement involved in cell motility uc007guh.1 uc007guh.2 uc007guh.3 uc007guh.4 
ENSMUST00000212907.2 9230110F11Rik ENSMUST00000212907.2 9230110F11Rik (from geneSymbol) ENSMUST00000212907.1 uc292csb.1 uc292csb.2 uc292csb.1 uc292csb.2 
ENSMUST00000212917.3 Gm45752 ENSMUST00000212917.3 predicted gene 45752 (from RefSeq NR_188753.1) ENSMUST00000212917.1 ENSMUST00000212917.2 NR_188753 uc009neu.1 uc009neu.2 uc009neu.3 uc009neu.4 uc009neu.1 uc009neu.2 uc009neu.3 uc009neu.4 
ENSMUST00000212932.2 Gm45848 ENSMUST00000212932.2 Gm45848 (from geneSymbol) ENSMUST00000212932.1 uc292akk.1 uc292akk.2 uc292akk.1 uc292akk.2 
ENSMUST00000212941.2 Gm39185 ENSMUST00000212941.2 Gm39185 (from geneSymbol) ENSMUST00000212941.1 uc292ahr.1 uc292ahr.2 uc292ahr.1 uc292ahr.2 
ENSMUST00000212943.4 Or7e178 ENSMUST00000212943.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BPL2) A0A2I3BPL2 A0A2I3BPL2_MOUSE BC120866 ENSMUST00000212943.1 ENSMUST00000212943.2 ENSMUST00000212943.3 Olfr18 Or7e178 uc292evn.1 uc292evn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292evn.1 uc292evn.2 
ENSMUST00000212945.2 Gm45830 ENSMUST00000212945.2 Gm45830 (from geneSymbol) ENSMUST00000212945.1 uc291zvk.1 uc291zvk.2 uc291zvk.1 uc291zvk.2 
ENSMUST00000212946.3 4930578M07Rik ENSMUST00000212946.3 4930578M07Rik (from geneSymbol) AK016308 ENSMUST00000212946.1 ENSMUST00000212946.2 uc292cxa.1 uc292cxa.2 uc292cxa.3 uc292cxa.1 uc292cxa.2 uc292cxa.3 
ENSMUST00000212975.2 ENSMUSG00000121420 ENSMUST00000212975.2 ENSMUSG00000121420 (from geneSymbol) ENSMUST00000212975.1 uc292crw.1 uc292crw.2 uc292crw.1 uc292crw.2 
ENSMUST00000212983.3 Or7d9 ENSMUST00000212983.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG88) ENSMUST00000212983.1 ENSMUST00000212983.2 Olfr39 Or7d9 Q8VG88 Q8VG88_MOUSE uc292evg.1 uc292evg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292evg.1 uc292evg.2 
ENSMUST00000212987.2 Sipa1l2 ENSMUST00000212987.2 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80TE4-1; Sequence=Displayed; Name=2; IsoId=Q80TE4-2; Sequence=VSP_016999; (from UniProt Q80TE4) BC072593 E9QPK7 ENSMUST00000212987.1 Kiaa0545 Q6PDY1 Q80TE4 SI1L2_MOUSE uc292eby.1 uc292eby.2 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80TE4-1; Sequence=Displayed; Name=2; IsoId=Q80TE4-2; Sequence=VSP_016999; molecular_function GTPase activator activity cellular_component biological_process positive regulation of GTPase activity regulation of small GTPase mediated signal transduction uc292eby.1 uc292eby.2 
ENSMUST00000212988.2 Gm45733 ENSMUST00000212988.2 Gm45733 (from geneSymbol) ENSMUST00000212988.1 LF225447 uc292dja.1 uc292dja.2 uc292dja.1 uc292dja.2 
ENSMUST00000212991.2 Cherp ENSMUST00000212991.2 calcium homeostasis endoplasmic reticulum protein, transcript variant 1 (from RefSeq NM_138585.3) A0A1D5RL92 A0A1D5RL92_MOUSE Cherp ENSMUST00000212991.1 NM_138585 uc009mga.1 uc009mga.2 uc009mga.3 nucleic acid binding RNA binding cytoplasm RNA processing cellular calcium ion homeostasis negative regulation of cell proliferation sarcoplasmic reticulum membrane ion channel binding perinuclear region of cytoplasm release of sequestered calcium ion into cytosol positive regulation of calcineurin-NFAT signaling cascade uc009mga.1 uc009mga.2 uc009mga.3 
ENSMUST00000212997.2 Gm55746 ENSMUST00000212997.2 Gm55746 (from geneSymbol) A0A1D5RM44 A0A1D5RM44_MOUSE BC138646 ENSMUST00000212997.1 Gm55746 uc290uxz.1 uc290uxz.2 membrane integral component of membrane uc290uxz.1 uc290uxz.2 
ENSMUST00000212999.4 Or7e174 ENSMUST00000212999.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFI8) A0A1D5RM56 ENSMUST00000212999.1 ENSMUST00000212999.2 ENSMUST00000212999.3 Olfr868 Or7e174 Q8VFI8 Q8VFI8_MOUSE uc292eva.1 uc292eva.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292eva.1 uc292eva.2 
ENSMUST00000213002.2 Gm35934 ENSMUST00000213002.2 predicted gene, 35934 (from RefSeq NR_176336.1) ENSMUST00000213002.1 NR_176336 uc291ynu.1 uc291ynu.2 uc291ynu.1 uc291ynu.2 
ENSMUST00000213014.2 8030455M16Rik ENSMUST00000213014.2 RIKEN cDNA 8030455M16 gene (from RefSeq NR_131069.1) ENSMUST00000213014.1 NR_131069 uc057ana.1 uc057ana.2 uc057ana.1 uc057ana.2 
ENSMUST00000213018.3 Or7g20 ENSMUST00000213018.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRG7) ENSMUST00000213018.1 ENSMUST00000213018.2 Olfr835 Or7g20 Q7TRG7 Q7TRG7_MOUSE uc292etd.1 uc292etd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292etd.1 uc292etd.2 
ENSMUST00000213019.2 Carmil2 ENSMUST00000213019.2 capping protein regulator and myosin 1 linker 2 (from RefSeq NM_001357333.1) Carmil2 ENSMUST00000213019.1 NM_001357333 Rltpr S0DHL8 S0DHL8_MOUSE uc033jhi.1 uc033jhi.2 uc033jhi.3 Belongs to the CARMIL family. ruffle phospholipid binding cytoplasm plasma membrane establishment or maintenance of cell polarity positive regulation of lamellipodium assembly actin cytoskeleton cell migration maintenance of cell polarity lamellipodium positive regulation of cell migration cell leading edge wound healing, spreading of cells macropinosome macromolecular complex binding intermediate filament cytoskeleton actin filament network formation establishment or maintenance of monopolar cell polarity positive regulation of extracellular matrix disassembly positive regulation of ruffle assembly positive regulation of lamellipodium organization negative regulation of barbed-end actin filament capping uc033jhi.1 uc033jhi.2 uc033jhi.3 
ENSMUST00000213021.2 Gm45786 ENSMUST00000213021.2 Gm45786 (from geneSymbol) ENSMUST00000213021.1 uc292ccu.1 uc292ccu.2 uc292ccu.1 uc292ccu.2 
ENSMUST00000213024.3 Or7e175 ENSMUST00000213024.3 olfactory receptor family 7 subfamily E member 175 (from RefSeq NM_146557.2) A0A2I3BRV7 A0A2I3BRV7_MOUSE ENSMUST00000213024.1 ENSMUST00000213024.2 NM_146557 Olfr869 Or7e175 uc009oic.1 uc009oic.2 uc009oic.3 uc009oic.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. CCDS Note: The coding region has been updated to extend the N-terminus to one that is supported by available conservation data. ##Evidence-Data-START## Transcript exon combination :: CB173035.1, DR065661.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oic.1 uc009oic.2 uc009oic.3 uc009oic.4 
ENSMUST00000213026.2 Crhr2 ENSMUST00000213026.2 corticotropin releasing hormone receptor 2, transcript variant 3 (from RefSeq NM_001288619.1) B9EHB5 CRFR2_MOUSE Crf2r ENSMUST00000213026.1 NM_001288619 Q5GL24 Q60748 Q60783 Q60808 uc009caj.1 uc009caj.2 uc009caj.3 uc009caj.4 uc009caj.5 G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Monomer. Interacts with CRF, UCN, UCN2 and UCN3 (By similarity). Cell membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=CRF2-alpha; IsoId=Q60748-1; Sequence=Displayed; Name=CRF2-beta; IsoId=Q60748-2; Sequence=VSP_053568; Highly expressed in the heart. Also expressed in lungs, skeletal muscle, gastrointestinal tract, epididymis, and brain. The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity). The uncleaved pseudo signal peptide prevents receptor's oligomerization and coupling to G(i) subunits. It is also responsible for the rather low receptor localization at the plasma membrane (By similarity). A N-glycosylation site within the signal peptide impedes its proper cleavage and function. [Isoform CRF2-beta]: Contains a disulfide bond in positions 45-70. Belongs to the G-protein coupled receptor 2 family. transmembrane signaling receptor activity G-protein coupled receptor activity hormone activity protein binding rough endoplasmic reticulum Golgi apparatus plasma membrane actin filament organization signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway protein kinase C-activating G-protein coupled receptor signaling pathway hormone-mediated signaling pathway cell surface positive regulation of heart rate positive regulation of gene expression negative regulation of gene expression negative regulation of norepinephrine secretion positive regulation of serotonin secretion corticotrophin-releasing factor receptor activity membrane integral component of membrane negative regulation of angiogenesis peptide hormone binding sensory perception of pain axon dendrite epithelial cell differentiation positive regulation of interleukin-6 production negative regulation of epinephrine secretion positive regulation of stress-activated MAPK cascade negative regulation of luteinizing hormone secretion gastric motility catecholamine biosynthetic process neuronal cell body varicosity perikaryon corticotropin-releasing hormone receptor activity axon terminus positive regulation of cAMP-mediated signaling positive regulation of blood pressure negative regulation of follicle-stimulating hormone secretion skeletal muscle tissue growth positive regulation of NF-kappaB transcription factor activity long-term synaptic potentiation negative regulation of insulin secretion involved in cellular response to glucose stimulus regulation of ERK1 and ERK2 cascade cell body fiber cellular response to corticotropin-releasing hormone stimulus negative regulation of calcium ion import negative regulation of feeding behavior negative regulation of defecation positive regulation of DNA biosynthetic process uc009caj.1 uc009caj.2 uc009caj.3 uc009caj.4 uc009caj.5 
ENSMUST00000213031.2 Gm45724 ENSMUST00000213031.2 Gm45724 (from geneSymbol) ENSMUST00000213031.1 uc292csy.1 uc292csy.2 uc292csy.1 uc292csy.2 
ENSMUST00000213048.3 ENSMUSG00000121424 ENSMUST00000213048.3 ENSMUSG00000121424 (from geneSymbol) ENSMUST00000213048.1 ENSMUST00000213048.2 uc292csq.1 uc292csq.2 uc292csq.3 uc292csq.1 uc292csq.2 uc292csq.3 
ENSMUST00000213052.3 Gm45709 ENSMUST00000213052.3 Gm45709 (from geneSymbol) ENSMUST00000213052.1 ENSMUST00000213052.2 uc292ebn.1 uc292ebn.2 uc292ebn.3 uc292ebn.1 uc292ebn.2 uc292ebn.3 
ENSMUST00000213063.2 Gm45706 ENSMUST00000213063.2 Gm45706 (from geneSymbol) ENSMUST00000213063.1 uc292bbm.1 uc292bbm.2 uc292bbm.1 uc292bbm.2 
ENSMUST00000213065.2 Gm3336 ENSMUST00000213065.2 Gm3336 (from geneSymbol) A0A1D5RMG6 A0A1D5RMG6_MOUSE AK010542 ENSMUST00000213065.1 Gm3336 uc009mbf.1 uc009mbf.2 uc009mbf.3 uc009mbf.4 molecular_function cellular_component biological_process membrane integral component of membrane uc009mbf.1 uc009mbf.2 uc009mbf.3 uc009mbf.4 
ENSMUST00000213073.2 Or7e171-ps1 ENSMUST00000213073.2 Or7e171-ps1 (from geneSymbol) ENSMUST00000213073.1 uc292eut.1 uc292eut.2 uc292eut.1 uc292eut.2 
ENSMUST00000213082.2 Gm45904 ENSMUST00000213082.2 Gm45904 (from geneSymbol) AK034258 ENSMUST00000213082.1 uc292dhy.1 uc292dhy.2 uc292dhy.1 uc292dhy.2 
ENSMUST00000213087.4 Or8b57 ENSMUST00000213087.4 Membrane ; Multi- pass membrane protein (from UniProt Q7TRA3) A0A1D5RLX5 ENSMUST00000213087.1 ENSMUST00000213087.2 ENSMUST00000213087.3 Olfr890 Olfr983 Or8b57 Q7TRA3 Q7TRA3_MOUSE uc033jjy.1 uc033jjy.2 uc033jjy.3 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033jjy.1 uc033jjy.2 uc033jjy.3 
ENSMUST00000213101.2 Or11h23 ENSMUST00000213101.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q9Z0) E9Q9Z0 E9Q9Z0_MOUSE ENSMUST00000213101.1 Olfr748 Or11h23 uc288tmf.1 uc288tmf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tmf.1 uc288tmf.2 
ENSMUST00000213103.3 Or10ag60 ENSMUST00000213103.3 olfactory receptor family 10 subfamily AG member 60 (from RefSeq NM_146838.2) A0A1L1SQT2 A0A1L1SQT2_MOUSE ENSMUST00000213103.1 ENSMUST00000213103.2 NM_146838 Olfr1130 Or10ag60 uc008kof.1 uc008kof.2 uc008kof.3 uc008kof.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB174039.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kof.1 uc008kof.2 uc008kof.3 uc008kof.4 
ENSMUST00000213105.2 Or8b43 ENSMUST00000213105.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q6Z7) E9Q6Z7 E9Q6Z7_MOUSE ENSMUST00000213105.1 Olfr902 Or8b43 uc292fyb.1 uc292fyb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fyb.1 uc292fyb.2 
ENSMUST00000213107.2 Gm48710 ENSMUST00000213107.2 Gm48710 (from geneSymbol) ENSMUST00000213107.1 uc292gfr.1 uc292gfr.2 uc292gfr.1 uc292gfr.2 
ENSMUST00000213112.3 4930442G15Rik ENSMUST00000213112.3 4930442G15Rik (from geneSymbol) AK019609 ENSMUST00000213112.1 ENSMUST00000213112.2 uc292hme.1 uc292hme.2 uc292hme.3 uc292hme.1 uc292hme.2 uc292hme.3 
ENSMUST00000213117.2 Btg4 ENSMUST00000213117.2 Belongs to the BTG family. (from UniProt A0A1L1SVH3) A0A1L1SVH3 A0A1L1SVH3_MOUSE AK162122 Btg4 ENSMUST00000213117.1 uc009ple.1 uc009ple.2 uc009ple.3 Belongs to the BTG family. negative regulation of cell proliferation uc009ple.1 uc009ple.2 uc009ple.3 
ENSMUST00000213118.2 Or4a27 ENSMUST00000213118.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR13) ENSMUST00000213118.1 Olfr1197 Or4a27 Q7TR13 Q7TR13_MOUSE uc289xzg.1 uc289xzg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xzg.1 uc289xzg.2 
ENSMUST00000213122.3 4930431F10Rik ENSMUST00000213122.3 RIKEN cDNA 4930431F10 gene (from RefSeq NR_166081.1) ENSMUST00000213122.1 ENSMUST00000213122.2 NR_166081 uc287qye.1 uc287qye.2 uc287qye.3 uc287qye.1 uc287qye.2 uc287qye.3 
ENSMUST00000213132.2 Gm26797 ENSMUST00000213132.2 predicted gene, 26797, transcript variant 1 (from RefSeq NR_168547.1) ENSMUST00000213132.1 NR_168547 uc292mly.1 uc292mly.2 uc292mly.1 uc292mly.2 
ENSMUST00000213136.2 Or4c29 ENSMUST00000213136.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q3SXJ3) ENSMUST00000213136.1 Olfr1209 Or4c29 Q3SXJ3 Q3SXJ3_MOUSE uc289xzx.1 uc289xzx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xzx.1 uc289xzx.2 
ENSMUST00000213137.2 5330432J10Rik ENSMUST00000213137.2 5330432J10Rik (from geneSymbol) AK030568 ENSMUST00000213137.1 uc292elf.1 uc292elf.2 uc292elf.1 uc292elf.2 
ENSMUST00000213140.2 Gm47542 ENSMUST00000213140.2 Gm47542 (from geneSymbol) ENSMUST00000213140.1 LF197539 uc292gkl.1 uc292gkl.2 uc292gkl.1 uc292gkl.2 
ENSMUST00000213142.2 Gm47106 ENSMUST00000213142.2 Gm47106 (from geneSymbol) ENSMUST00000213142.1 uc292kke.1 uc292kke.2 uc292kke.1 uc292kke.2 
ENSMUST00000213145.2 Or9r3 ENSMUST00000213145.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRH2) ENSMUST00000213145.1 Olfr823 Or9r3 Q7TRH2 Q7TRH2_MOUSE uc287wak.1 uc287wak.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287wak.1 uc287wak.2 
ENSMUST00000213154.2 Cep164 ENSMUST00000213154.2 Cep164 (from geneSymbol) A0A1L1SSA4 A0A1L1SSA4_MOUSE BC076567 Cep164 ENSMUST00000213154.1 uc012gsf.1 uc012gsf.2 uc012gsf.3 uc012gsf.1 uc012gsf.2 uc012gsf.3 
ENSMUST00000213157.2 Or4p18 ENSMUST00000213157.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AUS6) A2AUS6 A2AUS6_MOUSE ENSMUST00000213157.1 Olfr1179 Or4p18 uc289xye.1 uc289xye.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xye.1 uc289xye.2 
ENSMUST00000213164.2 Or8b55 ENSMUST00000213164.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG50) ENSMUST00000213164.1 Olfr922 Or8b55 Q8VG50 Q8VG50_MOUSE uc292fzf.1 uc292fzf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fzf.1 uc292fzf.2 
ENSMUST00000213169.2 Or2w25 ENSMUST00000213169.2 olfactory receptor family 2 subfamily W member 25 (from RefSeq NM_001011740.2) A0A1L1SQW2 A0A1L1SQW2_MOUSE ENSMUST00000213169.1 NM_001011740 Or2w25 uc287ynm.1 uc287ynm.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. There may be a polymorphism in the C-terminus of the encoded protein due to a single nucleotide insertion (rs228650303) found in some mouse strains. The GRCm38 reference genome encodes a protein with a poorly conserved C-terminus that is longer than other olfactory receptor proteins and may not function as an olfactory receptor. [provided by RefSeq, Jun 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on protein homology data. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ynm.1 uc287ynm.2 
ENSMUST00000213171.2 Or10d5j ENSMUST00000213171.2 olfactory receptor family 10 subfamily D member 5J, transcript variant 1 (from RefSeq NM_001360353.1) ENSMUST00000213171.1 NM_001360353 Olfr976 Or10d5j Q3UX31 Q3UX31_MOUSE uc009oyv.1 uc009oyv.2 uc009oyv.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK135940.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oyv.1 uc009oyv.2 uc009oyv.3 
ENSMUST00000213173.2 Gm47828 ENSMUST00000213173.2 Gm47828 (from geneSymbol) ENSMUST00000213173.1 uc292hfq.1 uc292hfq.2 uc292hfq.1 uc292hfq.2 
ENSMUST00000213180.3 Gm39326 ENSMUST00000213180.3 Gm39326 (from geneSymbol) ENSMUST00000213180.1 ENSMUST00000213180.2 uc292gsx.1 uc292gsx.2 uc292gsx.3 uc292gsx.1 uc292gsx.2 uc292gsx.3 
ENSMUST00000213185.2 Or8k33 ENSMUST00000213185.2 olfactory receptor family 8 subfamily K member 33 (from RefSeq NM_146409.2) ENSMUST00000213185.1 NM_146409 Olfr1080 Or8k33 Q7TR67 Q7TR67_MOUSE uc008kmo.1 uc008kmo.2 uc008kmo.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB174209.1, DR065603.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kmo.1 uc008kmo.2 uc008kmo.3 
ENSMUST00000213188.3 Or2t48 ENSMUST00000213188.3 olfactory receptor family 2 subfamily T member 48 (from RefSeq NM_146879.2) ENSMUST00000213188.1 ENSMUST00000213188.2 NM_146879 Olfr330 Or2t48 Q8VGD9 Q8VGD9_MOUSE uc007jbr.1 uc007jbr.2 uc007jbr.3 uc007jbr.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB173080.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007jbr.1 uc007jbr.2 uc007jbr.3 uc007jbr.4 
ENSMUST00000213189.3 Or13p10 ENSMUST00000213189.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7MU75) ENSMUST00000213189.1 ENSMUST00000213189.2 L7MU75 L7MU75_MOUSE Olfr62 Or13p10 uc008ukp.1 uc008ukp.2 uc008ukp.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008ukp.1 uc008ukp.2 uc008ukp.3 
ENSMUST00000213190.2 Or4p20 ENSMUST00000213190.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR18) ENSMUST00000213190.1 Olfr1181 Olfr1182 Or4p20 Q7TR18 Q7TR18_MOUSE uc289xyh.1 uc289xyh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xyh.1 uc289xyh.2 
ENSMUST00000213195.2 Gm47237 ENSMUST00000213195.2 Gm47237 (from geneSymbol) AK089723 ENSMUST00000213195.1 uc292hmd.1 uc292hmd.2 uc292hmd.1 uc292hmd.2 
ENSMUST00000213198.2 Or5t7 ENSMUST00000213198.2 Potential odorant receptor. (from UniProt Q8VFL9) ENSMUST00000213198.1 Mor179-2 OR5T7_MOUSE Olfr1086 Or5t7 Q8VFL9 uc289xsw.1 uc289xsw.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xsw.1 uc289xsw.2 
ENSMUST00000213204.2 Or52e4 ENSMUST00000213204.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF06) ENSMUST00000213204.1 Olfr677 Or52e4 Q8VF06 Q8VF06_MOUSE uc291twd.1 uc291twd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291twd.1 uc291twd.2 
ENSMUST00000213205.2 Or8k22 ENSMUST00000213205.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGS7) ENSMUST00000213205.1 Olfr1054 Or8k22 Q8VGS7 Q8VGS7_MOUSE uc289xrq.1 uc289xrq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xrq.1 uc289xrq.2 
ENSMUST00000213210.2 Or4k40 ENSMUST00000213210.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQY2) A0A0N4SUW6 ENSMUST00000213210.1 Olfr1285 Olfr1286 Or4k40 Q7TQY2 Q7TQY2_MOUSE uc289zev.1 uc289zev.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zev.1 uc289zev.2 
ENSMUST00000213214.2 Or51i2 ENSMUST00000213214.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGX6) ENSMUST00000213214.1 Olfr641 Or51i2 Q8VGX6 Q8VGX6_MOUSE uc291tsr.1 uc291tsr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tsr.1 uc291tsr.2 
ENSMUST00000213217.2 Or2n1c ENSMUST00000213217.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEY4) ENSMUST00000213217.1 Olfr135 Or2n1c Q8VEY4 Q8VEY4_MOUSE uc008cob.1 uc008cob.2 uc008cob.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008cob.1 uc008cob.2 uc008cob.3 
ENSMUST00000213218.2 Or1q1 ENSMUST00000213218.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFP4) ENSMUST00000213218.1 Olfr357 Or1q1 Q8VFP4 Q8VFP4_MOUSE uc008jmg.1 uc008jmg.2 uc008jmg.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008jmg.1 uc008jmg.2 uc008jmg.3 
ENSMUST00000213219.2 Gm48462 ENSMUST00000213219.2 Gm48462 (from geneSymbol) ENSMUST00000213219.1 uc288avp.1 uc288avp.2 uc288avp.1 uc288avp.2 
ENSMUST00000213221.2 Or4a73 ENSMUST00000213221.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQZ6) ENSMUST00000213221.1 Olfr1246 Olfr1252 Or4a73 Q7TQZ6 Q7TQZ6_MOUSE uc289ycy.1 uc289ycy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ycy.1 uc289ycy.2 
ENSMUST00000213222.2 Or6c3 ENSMUST00000213222.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFI0) ENSMUST00000213222.1 Olfr788 Or6c3 Q8VFI0 Q8VFI0_MOUSE uc287vxv.1 uc287vxv.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vxv.1 uc287vxv.2 
ENSMUST00000213224.2 Gm48902 ENSMUST00000213224.2 Gm48902 (from geneSymbol) ENSMUST00000213224.1 uc292fke.1 uc292fke.2 uc292fke.1 uc292fke.2 
ENSMUST00000213225.3 Or8k31-ps1 ENSMUST00000213225.3 olfactory receptor family 8 subfamily K member 31, pseudogene 1 (from RefSeq NR_033507.2) ENSMUST00000213225.1 ENSMUST00000213225.2 NR_033507 uc012byt.1 uc012byt.2 uc012byt.3 uc012byt.4 uc012byt.5 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Apr 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DR065539.1 [ECO:0000332] ##Evidence-Data-END## uc012byt.1 uc012byt.2 uc012byt.3 uc012byt.4 uc012byt.5 
ENSMUST00000213236.2 Or6c7 ENSMUST00000213236.2 olfactory receptor family 6 subfamily C member 7 (from RefSeq NM_001305433.1) A0A1L1SV77 A0A1L1SV77_MOUSE ENSMUST00000213236.1 NM_001305433 Olfr789 Or6c7 uc056yjc.1 uc056yjc.2 uc056yjc.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on orthologous data. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc056yjc.1 uc056yjc.2 uc056yjc.3 
ENSMUST00000213239.2 Or6c213 ENSMUST00000213239.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFI2) ENSMUST00000213239.1 Olfr806 Or6c213 Q8VFI2 Q8VFI2_MOUSE uc287vzb.1 uc287vzb.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vzb.1 uc287vzb.2 
ENSMUST00000213244.2 Gm48129 ENSMUST00000213244.2 Gm48129 (from geneSymbol) ENSMUST00000213244.1 uc292gdz.1 uc292gdz.2 uc292gdz.1 uc292gdz.2 
ENSMUST00000213246.3 Or8d6 ENSMUST00000213246.3 Membrane ; Multi- pass membrane protein (from UniProt Q8VH09) ENSMUST00000213246.1 ENSMUST00000213246.2 Olfr974 Or8d6 Q8VH09 Q8VH09_MOUSE uc009oyt.1 uc009oyt.2 uc009oyt.3 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oyt.1 uc009oyt.2 uc009oyt.3 
ENSMUST00000213247.2 Or9s13 ENSMUST00000213247.2 Odorant receptor. (from UniProt Q60894) ENSMUST00000213247.1 O9S13_MOUSE Olfr12 Or9s13 Q60894 Q7TQS5 uc287kml.1 uc287kml.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287kml.1 uc287kml.2 
ENSMUST00000213251.2 Or2d3 ENSMUST00000213251.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N662) A0A1B0GRA8 ENSMUST00000213251.1 K7N662 K7N662_MOUSE Olfr707 Or2d3 uc291udj.1 uc291udj.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291udj.1 uc291udj.2 
ENSMUST00000213252.2 Or5p50 ENSMUST00000213252.2 Potential odorant receptor. (from UniProt Q8VF66) ENSMUST00000213252.1 Mor204-21 O5P50_MOUSE Olfr469 Or5p50 Q8VF66 uc291ufj.1 uc291ufj.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ufj.1 uc291ufj.2 
ENSMUST00000213256.2 Or2y11 ENSMUST00000213256.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQT4) ENSMUST00000213256.1 Olfr1381 Or2y11 Q7TQT4 Q7TQT4_MOUSE uc287xuh.1 uc287xuh.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xuh.1 uc287xuh.2 
ENSMUST00000213258.2 Or1j17 ENSMUST00000213258.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGJ7) ENSMUST00000213258.1 Olfr346 Or1j17 Q8VGJ7 Q8VGJ7_MOUSE uc289vpf.1 uc289vpf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vpf.1 uc289vpf.2 
ENSMUST00000213259.2 Or1ad6 ENSMUST00000213259.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGH0) ENSMUST00000213259.1 Olfr1378 Or1ad6 Q8VGH0 Q8VGH0_MOUSE uc287xyb.1 uc287xyb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xyb.1 uc287xyb.2 
ENSMUST00000213260.2 Gm48821 ENSMUST00000213260.2 Gm48821 (from geneSymbol) ENSMUST00000213260.1 uc292jgz.1 uc292jgz.2 uc292jgz.1 uc292jgz.2 
ENSMUST00000213266.2 Or8g54 ENSMUST00000213266.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG89) ENSMUST00000213266.1 Olfr969 Or8g54 Q8VG89 Q8VG89_MOUSE uc292gce.1 uc292gce.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gce.1 uc292gce.2 
ENSMUST00000213281.2 Or51a5 ENSMUST00000213281.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRR8) ENSMUST00000213281.1 Olfr586 Or51a5 Q7TRR8 Q7TRR8_MOUSE uc291tpc.1 uc291tpc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tpc.1 uc291tpc.2 
ENSMUST00000213283.2 Or4c106 ENSMUST00000213283.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR10) ENSMUST00000213283.1 Olfr1204 Or4c106 Q7TR10 Q7TR10_MOUSE uc289xzs.1 uc289xzs.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xzs.1 uc289xzs.2 
ENSMUST00000213288.2 Or4c115 ENSMUST00000213288.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt F7BL62) ENSMUST00000213288.1 F7BL62 F7BL62_MOUSE Olfr1220 Or4c115 uc289yat.1 uc289yat.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yat.1 uc289yat.2 
ENSMUST00000213290.2 Or52b2 ENSMUST00000213290.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGW5) ENSMUST00000213290.1 Olfr691 Or52b2 Q8VGW5 Q8VGW5_MOUSE uc291txl.1 uc291txl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291txl.1 uc291txl.2 
ENSMUST00000213300.2 Or1j13 ENSMUST00000213300.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGK9) ENSMUST00000213300.1 Olfr340 Olfr341 Or1j13 Q8VGK9 Q8VGK9_MOUSE uc289vpa.1 uc289vpa.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vpa.1 uc289vpa.2 
ENSMUST00000213302.3 Or5w11 ENSMUST00000213302.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR45) A0A1L1SUI2 ENSMUST00000213302.1 ENSMUST00000213302.2 Olfr1131 Or5w11 Q7TR45 Q7TR45_MOUSE uc289xvx.1 uc289xvx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xvx.1 uc289xvx.2 
ENSMUST00000213308.3 Or5w19 ENSMUST00000213308.3 Odorant receptor. (from UniProt Q7TR34) ENSMUST00000213308.1 ENSMUST00000213308.2 Olfr1152 Or5w19 Q7TR34 Q7TR34_MOUSE uc289xwv.1 uc289xwv.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xwv.1 uc289xwv.2 
ENSMUST00000213311.3 4933407I05Rik ENSMUST00000213311.3 4933407I05Rik (from geneSymbol) AK076937 ENSMUST00000213311.1 ENSMUST00000213311.2 uc292hgg.1 uc292hgg.2 uc292hgg.3 uc292hgg.1 uc292hgg.2 uc292hgg.3 
ENSMUST00000213315.2 Or10ag59 ENSMUST00000213315.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AV41) A2AV41 A2AV41_MOUSE ENSMUST00000213315.1 Olfr1121 Olfr1129 Or10ag59 uc289xvt.1 uc289xvt.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xvt.1 uc289xvt.2 
ENSMUST00000213319.2 Gm48094 ENSMUST00000213319.2 Gm48094 (from geneSymbol) AK139621 ENSMUST00000213319.1 uc287qjo.1 uc287qjo.2 uc287qjo.1 uc287qjo.2 
ENSMUST00000213323.2 Or2y1g ENSMUST00000213323.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFA7) ENSMUST00000213323.1 Olfr1393 Or2y1g Q8VFA7 Q8VFA7_MOUSE uc287xth.1 uc287xth.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xth.1 uc287xth.2 
ENSMUST00000213326.2 Or2w1b ENSMUST00000213326.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A140T8K7) A0A140T8K7 A0A140T8K7_MOUSE ENSMUST00000213326.1 Olfr1369 Or2w1b uc288ldv.1 uc288ldv.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288ldv.1 uc288ldv.2 
ENSMUST00000213329.2 Or6c5c ENSMUST00000213329.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRI1) ENSMUST00000213329.1 Olfr787 Or6c5c Q7TRI1 Q7TRI1_MOUSE uc287vxu.1 uc287vxu.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vxu.1 uc287vxu.2 
ENSMUST00000213331.2 Or6c6c ENSMUST00000213331.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRH7) ENSMUST00000213331.1 Olfr804 Or6c6c Q7TRH7 Q7TRH7_MOUSE uc287vyv.1 uc287vyv.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vyv.1 uc287vyv.2 
ENSMUST00000213334.2 Gm47156 ENSMUST00000213334.2 Gm47156 (from geneSymbol) ENSMUST00000213334.1 uc287uet.1 uc287uet.2 uc287uet.1 uc287uet.2 
ENSMUST00000213336.2 Gm48677 ENSMUST00000213336.2 Gm48677 (from geneSymbol) ENSMUST00000213336.1 uc292ivk.1 uc292ivk.2 uc292ivk.1 uc292ivk.2 
ENSMUST00000213340.2 Gm47063 ENSMUST00000213340.2 Gm47063 (from geneSymbol) AK185597 ENSMUST00000213340.1 uc292mgb.1 uc292mgb.2 uc292mgb.1 uc292mgb.2 
ENSMUST00000213342.2 F930017D23Rik ENSMUST00000213342.2 F930017D23Rik (from geneSymbol) AK162643 ENSMUST00000213342.1 uc287qwq.1 uc287qwq.2 uc287qwq.1 uc287qwq.2 
ENSMUST00000213347.2 Slc6a16 ENSMUST00000213347.2 solute carrier family 6, member 16 (from RefSeq NM_001324535.1) A0A1L1SR47 A0A1L1SR47_MOUSE ENSMUST00000213347.1 NM_001324535 Slc6a16 uc057ltz.1 uc057ltz.2 uc057ltz.3 Membrane ; Multi- pass membrane protein neurotransmitter:sodium symporter activity plasma membrane neurotransmitter transport symporter activity membrane integral component of membrane transmembrane transport uc057ltz.1 uc057ltz.2 uc057ltz.3 
ENSMUST00000213348.2 Or5d44 ENSMUST00000213348.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BPQ2) A0A2I3BPQ2 A0A2I3BPQ2_MOUSE ENSMUST00000213348.1 Olfr1174 Olfr1174-ps Or5d44 uc289xxw.1 uc289xxw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxw.1 uc289xxw.2 
ENSMUST00000213353.2 Gm47857 ENSMUST00000213353.2 Gm47857 (from geneSymbol) ENSMUST00000213353.1 uc287qwa.1 uc287qwa.2 uc287qwa.1 uc287qwa.2 
ENSMUST00000213358.2 Or8g4 ENSMUST00000213358.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRA6) ENSMUST00000213358.1 Olfr967 Or8g4 Q7TRA6 Q7TRA6_MOUSE uc292gcc.1 uc292gcc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gcc.1 uc292gcc.2 
ENSMUST00000213359.3 Gm35024 ENSMUST00000213359.3 Gm35024 (from geneSymbol) ENSMUST00000213359.1 ENSMUST00000213359.2 uc292jbo.1 uc292jbo.2 uc292jbo.3 uc292jbo.1 uc292jbo.2 uc292jbo.3 
ENSMUST00000213364.2 ENSMUSG00000121435 ENSMUST00000213364.2 ENSMUSG00000121435 (from geneSymbol) ENSMUST00000213364.1 uc289xqk.1 uc289xqk.2 uc289xqk.1 uc289xqk.2 
ENSMUST00000213365.2 Or1e33 ENSMUST00000213365.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGR6) ENSMUST00000213365.1 Olfr393 Or1e33 Q8VGR6 Q8VGR6_MOUSE uc288aag.1 uc288aag.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288aag.1 uc288aag.2 
ENSMUST00000213366.3 Or12e7 ENSMUST00000213366.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR49) ENSMUST00000213366.1 ENSMUST00000213366.2 Olfr1126 Or12e7 Q7TR49 Q7TR49_MOUSE uc289xve.1 uc289xve.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xve.1 uc289xve.2 
ENSMUST00000213375.2 ENSMUSG00000121440 ENSMUST00000213375.2 ENSMUSG00000121440 (from geneSymbol) ENSMUST00000213375.1 uc289vou.1 uc289vou.2 uc289vou.1 uc289vou.2 
ENSMUST00000213377.2 B930092H01Rik ENSMUST00000213377.2 RIKEN cDNA B930092H01 gene (from RefSeq NR_045334.1) ENSMUST00000213377.1 NR_045334 uc029xbn.1 uc029xbn.2 uc029xbn.1 uc029xbn.2 
ENSMUST00000213381.2 Or10aa3 ENSMUST00000213381.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q8M2) E9Q8M2 E9Q8M2_MOUSE ENSMUST00000213381.1 Olfr432 Or10aa3 uc287obw.1 uc287obw.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287obw.1 uc287obw.2 
ENSMUST00000213385.2 Gm47162 ENSMUST00000213385.2 Gm47162 (from geneSymbol) ENSMUST00000213385.1 uc292mps.1 uc292mps.2 uc292mps.1 uc292mps.2 
ENSMUST00000213390.2 Or4l15 ENSMUST00000213390.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N5X7) ENSMUST00000213390.1 K7N5X7 K7N5X7_MOUSE Olfr724 Or4l15 uc288tkb.1 uc288tkb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tkb.1 uc288tkb.2 
ENSMUST00000213398.2 Or4k47 ENSMUST00000213398.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGE8) ENSMUST00000213398.1 Olfr1297 Or4k47 Q8VGE8 Q8VGE8_MOUSE uc289zfn.1 uc289zfn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zfn.1 uc289zfn.2 
ENSMUST00000213406.2 Gm47059 ENSMUST00000213406.2 Gm47059 (from geneSymbol) ENSMUST00000213406.1 uc292mfg.1 uc292mfg.2 uc292mfg.1 uc292mfg.2 
ENSMUST00000213412.2 Or4c15 ENSMUST00000213412.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR09) ENSMUST00000213412.1 Olfr1211 Or4c15 Q7TR09 Q7TR09_MOUSE uc289xzz.1 uc289xzz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xzz.1 uc289xzz.2 
ENSMUST00000213415.2 Or1ad8 ENSMUST00000213415.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGG9) ENSMUST00000213415.1 Olfr51 Or1ad8 Q8VGG9 Q8VGG9_MOUSE uc287xyg.1 uc287xyg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xyg.1 uc287xyg.2 
ENSMUST00000213420.2 Or10j2 ENSMUST00000213420.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A140T8J6) A0A140T8J6 A0A140T8J6_MOUSE ENSMUST00000213420.1 Olfr418 Or10j2 uc287oaa.1 uc287oaa.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287oaa.1 uc287oaa.2 
ENSMUST00000213425.2 Or6n2 ENSMUST00000213425.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q5F1) E9Q5F1 E9Q5F1_MOUSE ENSMUST00000213425.1 Olfr430 Or6n2 uc287oby.1 uc287oby.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287oby.1 uc287oby.2 
ENSMUST00000213432.2 Or51f5 ENSMUST00000213432.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGZ6) ENSMUST00000213432.1 Olfr561 Or51f5 Q8VGZ6 Q8VGZ6_MOUSE uc009isn.1 uc009isn.2 uc009isn.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009isn.1 uc009isn.2 uc009isn.3 
ENSMUST00000213434.2 Gm47575 ENSMUST00000213434.2 Gm47575 (from geneSymbol) ENSMUST00000213434.1 uc292kmh.1 uc292kmh.2 uc292kmh.1 uc292kmh.2 
ENSMUST00000213438.2 Or6c69 ENSMUST00000213438.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFU2) ENSMUST00000213438.1 Olfr816 Olfr822 Or6c69 Q8VFU2 Q8VFU2_MOUSE uc287vzv.1 uc287vzv.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vzv.1 uc287vzv.2 
ENSMUST00000213441.3 Or5m10 ENSMUST00000213441.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2ASU6) A2ASU6 A2ASU6_MOUSE ENSMUST00000213441.1 ENSMUST00000213441.2 Olfr1022 Olfr1023 Or5m10 uc289xpw.1 uc289xpw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xpw.1 uc289xpw.2 
ENSMUST00000213443.2 Gm47931 ENSMUST00000213443.2 Gm47931 (from geneSymbol) ENSMUST00000213443.1 uc292giy.1 uc292giy.2 uc292giy.1 uc292giy.2 
ENSMUST00000213446.3 4921528I07Rik ENSMUST00000213446.3 4921528I07Rik (from geneSymbol) AK077029 ENSMUST00000213446.1 ENSMUST00000213446.2 uc009rxc.1 uc009rxc.2 uc009rxc.3 uc009rxc.1 uc009rxc.2 uc009rxc.3 
ENSMUST00000213453.3 Or9g8 ENSMUST00000213453.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR95) ENSMUST00000213453.1 ENSMUST00000213453.2 Olfr1014 Or9g8 Q7TR95 Q7TR95_MOUSE uc289xpj.1 uc289xpj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xpj.1 uc289xpj.2 
ENSMUST00000213455.2 Gm36745 ENSMUST00000213455.2 Gm36745 (from geneSymbol) AK139415 ENSMUST00000213455.1 uc292lwt.1 uc292lwt.2 uc292lwt.1 uc292lwt.2 
ENSMUST00000213456.2 Or8h9 ENSMUST00000213456.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG37) ENSMUST00000213456.1 Olfr1099 Or8h9 Q8VG37 Q8VG37_MOUSE uc008knd.1 uc008knd.2 uc008knd.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008knd.1 uc008knd.2 uc008knd.3 
ENSMUST00000213462.2 Gm47508 ENSMUST00000213462.2 Gm47508 (from geneSymbol) AK029495 ENSMUST00000213462.1 uc287qmg.1 uc287qmg.2 uc287qmg.1 uc287qmg.2 
ENSMUST00000213474.3 Or5m13 ENSMUST00000213474.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A140T8K3) A0A140T8K3 A0A140T8K3_MOUSE ENSMUST00000213474.1 ENSMUST00000213474.2 Olfr1025 Or5m13 uc289xpy.1 uc289xpy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xpy.1 uc289xpy.2 
ENSMUST00000213480.2 Or2l13b ENSMUST00000213480.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF05) ENSMUST00000213480.1 Olfr168 Or2l13b Q8VF05 Q8VF05_MOUSE uc289dhn.1 uc289dhn.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289dhn.1 uc289dhn.2 
ENSMUST00000213481.2 Or51f1 ENSMUST00000213481.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1B0GST0) A0A1B0GST0 A0A1B0GST0_MOUSE ENSMUST00000213481.1 Olfr566 Or51f1 uc291toa.1 uc291toa.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291toa.1 uc291toa.2 
ENSMUST00000213493.2 Or5b106 ENSMUST00000213493.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFV9) ENSMUST00000213493.1 Olfr1459 Or5b106 Q8VFV9 Q8VFV9_MOUSE uc008gve.1 uc008gve.2 uc008gve.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gve.1 uc008gve.2 uc008gve.3 
ENSMUST00000213494.2 Gm47186 ENSMUST00000213494.2 Gm47186 (from geneSymbol) ENSMUST00000213494.1 uc292gpx.1 uc292gpx.2 uc292gpx.1 uc292gpx.2 
ENSMUST00000213496.2 Or5m9 ENSMUST00000213496.2 olfactory receptor family 5 subfamily M member 9 (from RefSeq NM_001011872.2) A0A1L1ST14 A0A1L1ST14_MOUSE ENSMUST00000213496.1 NM_001011872 Olfr1034 Or5m9 uc008kll.1 uc008kll.2 uc008kll.3 uc008kll.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC147677.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kll.1 uc008kll.2 uc008kll.3 uc008kll.4 
ENSMUST00000213505.2 Or2j3 ENSMUST00000213505.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFC2) ENSMUST00000213505.1 Olfr137 Or2j3 Q8VFC2 Q8VFC2_MOUSE uc008cod.1 uc008cod.2 uc008cod.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008cod.1 uc008cod.2 uc008cod.3 
ENSMUST00000213509.2 Gm47777 ENSMUST00000213509.2 Gm47777 (from geneSymbol) ENSMUST00000213509.1 uc292fon.1 uc292fon.2 uc292fon.1 uc292fon.2 
ENSMUST00000213510.2 Gm48651 ENSMUST00000213510.2 Gm48651 (from geneSymbol) ENSMUST00000213510.1 uc287pxj.1 uc287pxj.2 uc287pxj.1 uc287pxj.2 
ENSMUST00000213511.2 Or4k49 ENSMUST00000213511.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQX5) AK048911 ENSMUST00000213511.1 Olfr1299 Or4k49 Q7TQX5 Q7TQX5_MOUSE uc289zfp.1 uc289zfp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zfp.1 uc289zfp.2 
ENSMUST00000213512.2 Or6c206 ENSMUST00000213512.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRI3) ENSMUST00000213512.1 Olfr776 Or6c206 Q7TRI3 Q7TRI3_MOUSE uc287vxi.1 uc287vxi.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vxi.1 uc287vxi.2 
ENSMUST00000213515.2 Or5ar1 ENSMUST00000213515.2 Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanethiol (MTMT). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Probable). (from UniProt Q8VGS3) ENSMUST00000213515.1 Mor180-1 O5AR1_MOUSE Olfr1019 Or5ar1 Q8VGS3 uc289xps.1 uc289xps.2 Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanethiol (MTMT). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Probable). Copper binding enhances receptor activity in response to odorant binding. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity copper ion binding odorant binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane metal ion binding response to stimulus detection of chemical stimulus involved in sensory perception detection of chemical stimulus involved in sensory perception of smell uc289xps.1 uc289xps.2 
ENSMUST00000213521.3 Or5p72 ENSMUST00000213521.3 Potential odorant receptor. (from UniProt Q8VG08) ENSMUST00000213521.1 ENSMUST00000213521.2 Mor204-9 O5P72_MOUSE Olfr497 Or5p72 Q8VG08 uc291ugw.1 uc291ugw.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ugw.1 uc291ugw.2 
ENSMUST00000213522.2 Gm47815 ENSMUST00000213522.2 Gm47815 (from geneSymbol) ENSMUST00000213522.1 uc287qvr.1 uc287qvr.2 uc287qvr.1 uc287qvr.2 
ENSMUST00000213524.3 Celsr3 ENSMUST00000213524.3 cadherin, EGF LAG seven-pass G-type receptor 3, transcript variant 2 (from RefSeq NM_001359573.1) A0A1L1SUG9 A0A1L1SUG9_MOUSE Celsr3 ENSMUST00000213524.1 ENSMUST00000213524.2 NM_001359573 uc009rrc.1 uc009rrc.2 uc009rrc.3 Receptor that may have an important role in cell/cell signaling during nervous system formation. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. transmembrane signaling receptor activity G-protein coupled receptor activity calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway membrane integral component of membrane uc009rrc.1 uc009rrc.2 uc009rrc.3 
ENSMUST00000213538.3 Gm31378 ENSMUST00000213538.3 Gm31378 (from geneSymbol) ENSMUST00000213538.1 ENSMUST00000213538.2 uc287qno.1 uc287qno.2 uc287qno.3 uc287qno.1 uc287qno.2 uc287qno.3 
ENSMUST00000213540.3 Or52p2 ENSMUST00000213540.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG23) ENSMUST00000213540.1 ENSMUST00000213540.2 Olfr551 Or52p2 Q8VG23 Q8VG23_MOUSE uc291tnc.1 uc291tnc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tnc.1 uc291tnc.2 
ENSMUST00000213541.2 Gm48314 ENSMUST00000213541.2 Gm48314 (from geneSymbol) ENSMUST00000213541.1 uc292gsw.1 uc292gsw.2 uc292gsw.1 uc292gsw.2 
ENSMUST00000213545.2 Or4c103 ENSMUST00000213545.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG21) ENSMUST00000213545.1 Olfr1195 Or4c103 Q8VG21 Q8VG21_MOUSE uc289xzd.1 uc289xzd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xzd.1 uc289xzd.2 
ENSMUST00000213546.3 Or52ae7 ENSMUST00000213546.3 olfactory receptor family 52 subfamily AE member 7 (from RefSeq NM_146756.2) E9Q564 E9Q564_MOUSE ENSMUST00000213546.1 ENSMUST00000213546.2 NM_146756 Olfr608 Or52ae7 uc009itu.1 uc009itu.2 uc009itu.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This sequence is assembled by in silico methods with additional support of similarity to mouse olfactory receptors. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009itu.1 uc009itu.2 uc009itu.3 
ENSMUST00000213549.2 Or6z1 ENSMUST00000213549.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGH3) A0A140LIF5 ENSMUST00000213549.1 Olfr1348 Or6z1 Q8VGH3 Q8VGH3_MOUSE uc291lcj.1 uc291lcj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291lcj.1 uc291lcj.2 
ENSMUST00000213553.2 Gm30570 ENSMUST00000213553.2 predicted gene, 30570 (from RefSeq NR_152620.1) ENSMUST00000213553.1 NR_152620 uc287pgl.1 uc287pgl.2 uc287pgl.1 uc287pgl.2 
ENSMUST00000213556.3 Or5bh3 ENSMUST00000213556.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF35) ENSMUST00000213556.1 ENSMUST00000213556.2 Olfr1323 Or5bh3 Q8VF35 Q8VF35_MOUSE uc292obx.1 uc292obx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292obx.1 uc292obx.2 
ENSMUST00000213559.3 Or4f6 ENSMUST00000213559.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF85) ENSMUST00000213559.1 ENSMUST00000213559.2 Olfr1310 Or4f6 Q8VF85 Q8VF85_MOUSE uc008log.1 uc008log.2 uc008log.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008log.1 uc008log.2 uc008log.3 
ENSMUST00000213564.3 Or8k53 ENSMUST00000213564.3 olfactory receptor family 8 subfamily K member 53, transcript variant 1 (from RefSeq NM_001310551.1) A2AVX9 A2AVX9_MOUSE ENSMUST00000213564.1 ENSMUST00000213564.2 NM_001310551 Olfr1055 Or8k53 uc289xrs.1 uc289xrs.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xrs.1 uc289xrs.2 
ENSMUST00000213568.2 Or9k7 ENSMUST00000213568.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEV5) ENSMUST00000213568.1 Olfr827 Or9k7 Q8VEV5 Q8VEV5_MOUSE uc007hrh.1 uc007hrh.2 uc007hrh.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hrh.1 uc007hrh.2 uc007hrh.3 
ENSMUST00000213573.2 Gm47140 ENSMUST00000213573.2 Gm47140 (from geneSymbol) ENSMUST00000213573.1 LF197884 uc292mne.1 uc292mne.2 uc292mne.1 uc292mne.2 
ENSMUST00000213574.2 Or1l8 ENSMUST00000213574.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFP6) ENSMUST00000213574.1 Olfr355 Or1l8 Q8VFP6 Q8VFP6_MOUSE uc289vqa.1 uc289vqa.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vqa.1 uc289vqa.2 
ENSMUST00000213579.2 Or6c8 ENSMUST00000213579.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG33) ENSMUST00000213579.1 Olfr767 Or6c8 Q8VG33 Q8VG33_MOUSE uc007hpi.1 uc007hpi.2 uc007hpi.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hpi.1 uc007hpi.2 uc007hpi.3 
ENSMUST00000213586.2 Gm39312 ENSMUST00000213586.2 Gm39312 (from geneSymbol) ENSMUST00000213586.1 uc292fid.1 uc292fid.2 uc292fid.1 uc292fid.2 
ENSMUST00000213589.2 Or8c19-ps1 ENSMUST00000213589.2 Or8c19-ps1 (from geneSymbol) ENSMUST00000213589.1 uc292fxr.1 uc292fxr.2 uc292fxr.1 uc292fxr.2 
ENSMUST00000213590.2 Gm48814 ENSMUST00000213590.2 Gm48814 (from geneSymbol) ENSMUST00000213590.1 uc292gia.1 uc292gia.2 uc292gia.1 uc292gia.2 
ENSMUST00000213592.2 Gm48478 ENSMUST00000213592.2 Gm48478 (from geneSymbol) ENSMUST00000213592.1 uc292ffa.1 uc292ffa.2 uc292ffa.1 uc292ffa.2 
ENSMUST00000213594.2 Gm39327 ENSMUST00000213594.2 Gm39327 (from geneSymbol) ENSMUST00000213594.1 uc292gum.1 uc292gum.2 uc292gum.1 uc292gum.2 
ENSMUST00000213601.2 Or5p4 ENSMUST00000213601.2 Potential odorant receptor. (from UniProt Q8VGI5) ENSMUST00000213601.1 Mor204-2 OR5P4_MOUSE Olfr481 Or5p4 Q8VGI5 uc291ugb.1 uc291ugb.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ugb.1 uc291ugb.2 
ENSMUST00000213606.2 Or5b21 ENSMUST00000213606.2 Odorant receptor. (from UniProt Q8VFX2) ENSMUST00000213606.1 Mor202-4 O5B21_MOUSE Olfr1444 Or5b21 Q8VFX2 uc008gur.1 uc008gur.2 uc008gur.3 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gur.1 uc008gur.2 uc008gur.3 
ENSMUST00000213610.2 Fignl2 ENSMUST00000213610.2 fidgetin-like 2 (from RefSeq NM_001214911.3) ENSMUST00000213610.1 Fignl2 J3QK54 J3QK54_MOUSE NM_001214911 uc289bmw.1 uc289bmw.2 ATP binding nucleus microtubule-severing ATPase activity regulation of double-strand break repair via homologous recombination ATPase activity cytoplasmic microtubule organization microtubule severing uc289bmw.1 uc289bmw.2 
ENSMUST00000213613.3 Gm48831 ENSMUST00000213613.3 Gm48831 (from geneSymbol) ENSMUST00000213613.1 ENSMUST00000213613.2 uc292jhd.1 uc292jhd.2 uc292jhd.3 uc292jhd.1 uc292jhd.2 uc292jhd.3 
ENSMUST00000213616.3 Or11i1 ENSMUST00000213616.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFC3) ENSMUST00000213616.1 ENSMUST00000213616.2 Olfr266 Or11i1 Q8VFC3 Q8VFC3_MOUSE uc008qwn.1 uc008qwn.2 uc008qwn.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008qwn.1 uc008qwn.2 uc008qwn.3 
ENSMUST00000213617.2 Gm47445 ENSMUST00000213617.2 Gm47445 (from geneSymbol) AK134429 ENSMUST00000213617.1 uc287qma.1 uc287qma.2 uc287qma.1 uc287qma.2 
ENSMUST00000213619.2 Or8b56 ENSMUST00000213619.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt F6WBH4) ENSMUST00000213619.1 F6WBH4 F6WBH4_MOUSE Olfr923 Or8b56 uc292fzh.1 uc292fzh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fzh.1 uc292fzh.2 
ENSMUST00000213622.2 Or52e5 ENSMUST00000213622.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG26) ENSMUST00000213622.1 Olfr678 Or52e5 Q8VG26 Q8VG26_MOUSE uc291twf.1 uc291twf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291twf.1 uc291twf.2 
ENSMUST00000213623.2 Or10a5 ENSMUST00000213623.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EPG3) ENSMUST00000213623.1 Olfr713 Or10a5 Q9EPG3 Q9EPG3_MOUSE uc291uea.1 uc291uea.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uea.1 uc291uea.2 
ENSMUST00000213625.2 Mbd3l1 ENSMUST00000213625.2 methyl-CpG binding domain protein 3-like 1, transcript variant 2 (from RefSeq NM_001357418.1) ENSMUST00000213625.1 MB3L1_MOUSE Mbd3l NM_001357418 Q6P8W5 Q9D2S3 Q9D9H3 uc033jiz.1 uc033jiz.2 uc033jiz.3 Transcriptional repressor. Nucleus Note=Nuclear, in large foci. Highly expressed in testis. Not detected in the other tissues tested. The N-terminal half of the protein mediates transcription repression. Does not bind methylated DNA. Belongs to the MBD3L family. negative regulation of transcription from RNA polymerase II promoter nucleus methylation-dependent chromatin silencing methyl-CpG binding uc033jiz.1 uc033jiz.2 uc033jiz.3 
ENSMUST00000213631.2 Or10ah1-ps1 ENSMUST00000213631.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BPT7) A0A2I3BPT7 A0A2I3BPT7_MOUSE ENSMUST00000213631.1 Or10ah1-ps1 uc291bln.1 uc291bln.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291bln.1 uc291bln.2 
ENSMUST00000213638.3 Or2g25 ENSMUST00000213638.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N1Z1) ENSMUST00000213638.1 ENSMUST00000213638.2 L7N1Z1 L7N1Z1_MOUSE Olfr117 Or2g25 uc289lai.1 uc289lai.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lai.1 uc289lai.2 
ENSMUST00000213645.2 Zc3h12c ENSMUST00000213645.2 zinc finger CCCH type containing 12C, transcript variant 2 (from RefSeq NM_001368810.1) ENSMUST00000213645.1 Kiaa1726 NM_001368810 Q5DTV4 ZC12C_MOUSE uc009plw.1 uc009plw.2 uc009plw.3 May function as RNase and regulate the levels of target RNA species. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; By bacterial lipopolysaccharides (LPS) in macrophage cell line RAW 264.7. Belongs to the ZC3H12 family. molecular_function nuclease activity endonuclease activity cellular_component biological_process hydrolase activity metal ion binding nucleic acid phosphodiester bond hydrolysis uc009plw.1 uc009plw.2 uc009plw.3 
ENSMUST00000213646.3 Gm26737 ENSMUST00000213646.3 Gm26737 (from geneSymbol) AK134203 ENSMUST00000213646.1 ENSMUST00000213646.2 uc292gmd.1 uc292gmd.2 uc292gmd.3 uc292gmd.1 uc292gmd.2 uc292gmd.3 
ENSMUST00000213649.2 Or2a54 ENSMUST00000213649.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFS5) ENSMUST00000213649.1 Olfr441 Or2a54 Q8VFS5 Q8VFS5_MOUSE uc291dzr.1 uc291dzr.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dzr.1 uc291dzr.2 
ENSMUST00000213651.2 Or6b9 ENSMUST00000213651.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A0R4J0M0) A0A0R4J0M0 A0A0R4J0M0_MOUSE ENSMUST00000213651.1 Olfr6 Or6b9 uc291uds.1 uc291uds.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uds.1 uc291uds.2 
ENSMUST00000213656.2 Or10am5 ENSMUST00000213656.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQV1) A0A140LJ94 ENSMUST00000213656.1 Olfr1349 Or10am5 Q7TQV1 Q7TQV1_MOUSE uc291lct.1 uc291lct.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291lct.1 uc291lct.2 
ENSMUST00000213667.3 Gm10310 ENSMUST00000213667.3 predicted pseudogene 10310 (from RefSeq NM_001370880.1) ENSMUST00000213667.1 ENSMUST00000213667.2 Gm10310 NM_001370880 Olfr247 Or10u3 Q7TS26 Q7TS26_MOUSE uc287wab.1 uc287wab.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287wab.1 uc287wab.2 
ENSMUST00000213668.2 Or11g2 ENSMUST00000213668.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRM0) ENSMUST00000213668.1 Olfr744 Or11g2 Q7TRM0 Q7TRM0_MOUSE uc007tlg.1 uc007tlg.2 uc007tlg.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007tlg.1 uc007tlg.2 uc007tlg.3 
ENSMUST00000213675.2 4933432G23Rik ENSMUST00000213675.2 RIKEN cDNA 4933432G23 gene (from RefSeq NR_040716.1) ENSMUST00000213675.1 NR_040716 uc029xgn.1 uc029xgn.2 uc029xgn.3 uc029xgn.1 uc029xgn.2 uc029xgn.3 
ENSMUST00000213677.3 D830035M03Rik ENSMUST00000213677.3 RIKEN cDNA D830035M03 gene (from RefSeq NR_166642.1) ENSMUST00000213677.1 ENSMUST00000213677.2 NR_166642 uc009sco.1 uc009sco.2 uc009sco.3 uc009sco.1 uc009sco.2 uc009sco.3 
ENSMUST00000213679.2 Or4c102 ENSMUST00000213679.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AV11) A2AV11 A2AV11_MOUSE ENSMUST00000213679.1 Olfr1189 Olfr1230 Or4c102 uc289xys.1 uc289xys.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xys.1 uc289xys.2 
ENSMUST00000213681.2 Gm1715 ENSMUST00000213681.2 predicted gene 1715 (from RefSeq NR_045333.1) ENSMUST00000213681.1 NR_045333 uc029wyw.1 uc029wyw.2 uc029wyw.3 uc029wyw.1 uc029wyw.2 uc029wyw.3 
ENSMUST00000213683.2 Thyn1 ENSMUST00000213683.2 Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. (from UniProt Q91YJ3) BC016594 ENSMUST00000213683.1 Q91YJ3 THYN1_MOUSE Thy28 uc292fjd.1 uc292fjd.2 Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Nucleus Expressed in the medulla containing mature thymocytes, but not the cortex having immature thymocytes (at protein level). Abundant expression seen in testis, liver, brain and kidney with lower levels of the expression in thymus, spleen, heart and stomach. Down-regulated upon induction of apoptosis. Phosphorylated. molecular_function nucleus biological_process uc292fjd.1 uc292fjd.2 
ENSMUST00000213685.2 Or4k1 ENSMUST00000213685.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRM6) ENSMUST00000213685.1 Olfr728 Or4k1 Q7TRM6 Q7TRM6_MOUSE uc288tkp.1 uc288tkp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tkp.1 uc288tkp.2 
ENSMUST00000213688.2 Or8b8 ENSMUST00000213688.2 Odorant receptor. (from UniProt Q60882) ENSMUST00000213688.1 Mor161-6 OR8B8_MOUSE Olfr145 Olfr7 Or8b8 Q60882 Q9EQB0 uc292fwp.1 uc292fwp.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fwp.1 uc292fwp.2 
ENSMUST00000213692.2 Gm40608 ENSMUST00000213692.2 Gm40608 (from geneSymbol) ENSMUST00000213692.1 uc287pxy.1 uc287pxy.2 uc287pxy.1 uc287pxy.2 
ENSMUST00000213701.2 Or4n4 ENSMUST00000213701.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFT5) ENSMUST00000213701.1 Olfr732 Or4n4 Q8VFT5 Q8VFT5_MOUSE uc288tkz.1 uc288tkz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tkz.1 uc288tkz.2 
ENSMUST00000213703.3 Gm39384 ENSMUST00000213703.3 Gm39384 (from geneSymbol) ENSMUST00000213703.1 ENSMUST00000213703.2 uc292jfy.1 uc292jfy.2 uc292jfy.3 uc292jfy.1 uc292jfy.2 uc292jfy.3 
ENSMUST00000213707.2 Or2y12 ENSMUST00000213707.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQT3) ENSMUST00000213707.1 Olfr1382 Or2y12 Q7TQT3 Q7TQT3_MOUSE uc287xue.1 uc287xue.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xue.1 uc287xue.2 
ENSMUST00000213709.3 Gm48853 ENSMUST00000213709.3 Gm48853 (from geneSymbol) ENSMUST00000213709.1 ENSMUST00000213709.2 uc292god.1 uc292god.2 uc292god.3 uc292god.1 uc292god.2 uc292god.3 
ENSMUST00000213713.2 Or5b12 ENSMUST00000213713.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFX1) ENSMUST00000213713.1 Olfr1448 Or5b12 Q8VFX1 Q8VFX1_MOUSE uc289rdo.1 uc289rdo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rdo.1 uc289rdo.2 
ENSMUST00000213720.3 Or4c10 ENSMUST00000213720.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGN6) ENSMUST00000213720.1 ENSMUST00000213720.2 Olfr1258 Or4c10 Q8VGN6 Q8VGN6_MOUSE uc289ydu.1 uc289ydu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ydu.1 uc289ydu.2 
ENSMUST00000213732.2 Or10al3 ENSMUST00000213732.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRJ5) ENSMUST00000213732.1 Olfr119 Or10al3 Q7TRJ5 Q7TRJ5_MOUSE uc289lal.1 uc289lal.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lal.1 uc289lal.2 
ENSMUST00000213737.2 Or4f56 ENSMUST00000213737.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AVW3) A2AVW3 A2AVW3_MOUSE ENSMUST00000213737.1 Olfr1305 Or4f56 uc289zgb.1 uc289zgb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zgb.1 uc289zgb.2 
ENSMUST00000213738.2 Gm49318 ENSMUST00000213738.2 Gm49318 (from geneSymbol) A0A1L1SR50 A0A1L1SR50_MOUSE AY072705 ENSMUST00000213738.1 Gm49318 uc292fea.1 uc292fea.2 uc292fea.1 uc292fea.2 
ENSMUST00000213741.2 Gm47089 ENSMUST00000213741.2 Gm47089 (from geneSymbol) ENSMUST00000213741.1 uc292eli.1 uc292eli.2 uc292eli.1 uc292eli.2 
ENSMUST00000213748.2 Or6k2 ENSMUST00000213748.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q4G0) E9Q4G0 E9Q4G0_MOUSE ENSMUST00000213748.1 Olfr420 Or6k2 uc287oci.1 uc287oci.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287oci.1 uc287oci.2 
ENSMUST00000213749.2 Or5ak22 ENSMUST00000213749.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGC6) ENSMUST00000213749.1 Olfr992 Or5ak22 Q8VGC6 Q8VGC6_MOUSE uc289xol.1 uc289xol.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xol.1 uc289xol.2 
ENSMUST00000213754.2 Or3a1b ENSMUST00000213754.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFX6) ENSMUST00000213754.1 Olfr401 Or3a1b Q8VFX6 Q8VFX6_MOUSE uc288abf.1 uc288abf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288abf.1 uc288abf.2 
ENSMUST00000213759.2 Or5an9 ENSMUST00000213759.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF59) ENSMUST00000213759.1 Olfr1431 Or5an9 Q8VF59 Q8VF59_MOUSE uc289rbf.1 uc289rbf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rbf.1 uc289rbf.2 
ENSMUST00000213776.2 Or2y14 ENSMUST00000213776.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFA8) ENSMUST00000213776.1 Olfr1384 Or2y14 Q8VFA8 Q8VFA8_MOUSE uc287xub.1 uc287xub.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xub.1 uc287xub.2 
ENSMUST00000213777.2 Mbd3l2 ENSMUST00000213777.2 methyl-CpG binding domain protein 3-like 2 (from RefSeq NM_144934.3) ENSMUST00000213777.1 Mbd3l2 NM_144934 Q3UXB0 Q3UXB0_MOUSE uc009ogr.1 uc009ogr.2 uc009ogr.3 uc009ogr.4 negative regulation of transcription from RNA polymerase II promoter nucleus methylation-dependent chromatin silencing methyl-CpG binding uc009ogr.1 uc009ogr.2 uc009ogr.3 uc009ogr.4 
ENSMUST00000213778.2 Or5d46 ENSMUST00000213778.2 Membrane ; Multi- pass membrane protein (from UniProt Q8VG40) ENSMUST00000213778.1 Olfr1176 Or5d46 Q8VG40 Q8VG40_MOUSE uc008kpp.1 uc008kpp.2 uc008kpp.3 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kpp.1 uc008kpp.2 uc008kpp.3 
ENSMUST00000213792.2 Or12e9 ENSMUST00000213792.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7MTT1) ENSMUST00000213792.1 L7MTT1 L7MTT1_MOUSE Olfr1121 Or12e9 uc289xuy.1 uc289xuy.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xuy.1 uc289xuy.2 
ENSMUST00000213796.3 Gm34113 ENSMUST00000213796.3 Gm34113 (from geneSymbol) ENSMUST00000213796.1 ENSMUST00000213796.2 uc287tqv.1 uc287tqv.2 uc287tqv.3 uc287tqv.1 uc287tqv.2 uc287tqv.3 
ENSMUST00000213800.2 Gm48197 ENSMUST00000213800.2 Gm48197 (from geneSymbol) AK081794 ENSMUST00000213800.1 uc007evk.1 uc007evk.2 uc007evk.1 uc007evk.2 
ENSMUST00000213801.2 Or13a21 ENSMUST00000213801.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGT4) ENSMUST00000213801.1 Olfr532 Or13a21 Q8VGT4 Q8VGT4_MOUSE uc291wun.1 uc291wun.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291wun.1 uc291wun.2 
ENSMUST00000213802.2 Gm48842 ENSMUST00000213802.2 Gm48842 (from geneSymbol) ENSMUST00000213802.1 uc292jhl.1 uc292jhl.2 uc292jhl.1 uc292jhl.2 
ENSMUST00000213806.2 Or5b102 ENSMUST00000213806.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFW2) ENSMUST00000213806.1 Olfr1454 Or5b102 Q8VFW2 Q8VFW2_MOUSE uc289rdy.1 uc289rdy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rdy.1 uc289rdy.2 
ENSMUST00000213810.2 Gm39465 ENSMUST00000213810.2 Gm39465 (from geneSymbol) ENSMUST00000213810.1 uc292mla.1 uc292mla.2 uc292mla.1 uc292mla.2 
ENSMUST00000213811.2 Gm48275 ENSMUST00000213811.2 Gm48275 (from geneSymbol) ENSMUST00000213811.1 uc287rbq.1 uc287rbq.2 uc287rbq.1 uc287rbq.2 
ENSMUST00000213817.2 Or1b1 ENSMUST00000213817.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGV7) ENSMUST00000213817.1 Olfr362 Or1b1 Q8VGV7 Q8VGV7_MOUSE uc289vqj.1 uc289vqj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vqj.1 uc289vqj.2 
ENSMUST00000213819.2 Or7c74 ENSMUST00000213819.2 Or7c74 (from geneSymbol) ENSMUST00000213819.1 uc289vqt.1 uc289vqt.2 uc289vqt.1 uc289vqt.2 
ENSMUST00000213826.2 Gm49373 ENSMUST00000213826.2 Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; (from UniProt A0A1L1SV24) A0A1L1SV24 A0A1L1SV24_MOUSE AK052443 ENSMUST00000213826.1 Gm49373 uc292eza.1 uc292eza.2 Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence=; Mitochondrion matrix Belongs to the adrenodoxin/putidaredoxin family. electron carrier activity electron transport chain iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding uc292eza.1 uc292eza.2 
ENSMUST00000213828.2 Gm47002 ENSMUST00000213828.2 Gm47002 (from geneSymbol) ENSMUST00000213828.1 uc292ekn.1 uc292ekn.2 uc292ekn.1 uc292ekn.2 
ENSMUST00000213832.2 Or6k14 ENSMUST00000213832.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q7E7) E9Q7E7 E9Q7E7_MOUSE ENSMUST00000213832.1 Olfr427 Or6k14 uc007dsr.1 uc007dsr.2 uc007dsr.3 uc007dsr.4 uc007dsr.5 uc007dsr.6 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007dsr.1 uc007dsr.2 uc007dsr.3 uc007dsr.4 uc007dsr.5 uc007dsr.6 
ENSMUST00000213833.2 Or4a47 ENSMUST00000213833.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGP1) ENSMUST00000213833.1 Olfr1256 Or4a47 Q8VGP1 Q8VGP1_MOUSE uc289ydp.1 uc289ydp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ydp.1 uc289ydp.2 
ENSMUST00000213834.2 Or7g33 ENSMUST00000213834.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGG6) ENSMUST00000213834.1 Olfr853 Or7g33 Q8VGG6 Q8VGG6_MOUSE uc292eua.1 uc292eua.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292eua.1 uc292eua.2 
ENSMUST00000213835.2 Or5w12 ENSMUST00000213835.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR42) ENSMUST00000213835.1 Olfr1132 Olfr1135 Or5w12 Q7TR42 Q7TR42_MOUSE uc289xwc.1 uc289xwc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xwc.1 uc289xwc.2 
ENSMUST00000213837.2 Or5g23 ENSMUST00000213837.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR99) ENSMUST00000213837.1 Olfr1000 Or5g23 Q7TR99 Q7TR99_MOUSE uc289xow.1 uc289xow.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xow.1 uc289xow.2 
ENSMUST00000213839.2 Gm4657 ENSMUST00000213839.2 Gm4657 (from geneSymbol) ENSMUST00000213839.1 uc292lwj.1 uc292lwj.2 uc292lwj.1 uc292lwj.2 
ENSMUST00000213840.2 Or51b6b ENSMUST00000213840.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q382) E9Q382 E9Q382_MOUSE ENSMUST00000213840.1 Olfr623 Or51b6b uc291trk.1 uc291trk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291trk.1 uc291trk.2 
ENSMUST00000213841.3 Gm48728 ENSMUST00000213841.3 Gm48728 (from geneSymbol) ENSMUST00000213841.1 ENSMUST00000213841.2 uc287plb.1 uc287plb.2 uc287plb.3 uc287plb.1 uc287plb.2 uc287plb.3 
ENSMUST00000213844.2 Or14j5 ENSMUST00000213844.2 Odorant receptor. (from UniProt Q8VGF0) ENSMUST00000213844.1 Olfr126 Or14j5 Q8VGF0 Q8VGF0_MOUSE uc289laz.1 uc289laz.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289laz.1 uc289laz.2 
ENSMUST00000213846.2 Gm40623 ENSMUST00000213846.2 Gm40623 (from geneSymbol) ENSMUST00000213846.1 uc287qmx.1 uc287qmx.2 uc287qmx.1 uc287qmx.2 
ENSMUST00000213851.2 ENSMUSG00000121445 ENSMUST00000213851.2 ENSMUSG00000121445 (from geneSymbol) ENSMUST00000213851.1 uc292mpt.1 uc292mpt.2 uc292mpt.1 uc292mpt.2 
ENSMUST00000213857.2 Or14j1 ENSMUST00000213857.2 Odorant receptor. (from UniProt Q14AJ9) ENSMUST00000213857.1 Olfr125 Or14j1 Q14AJ9 Q14AJ9_MOUSE uc289lax.1 uc289lax.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lax.1 uc289lax.2 
ENSMUST00000213869.2 Or14a259 ENSMUST00000213869.2 Odorant receptor. (from UniProt Q7TS02) ENSMUST00000213869.1 Olfr305 Or14a259 Q7TS02 Q7TS02_MOUSE uc291siy.1 uc291siy.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291siy.1 uc291siy.2 
ENSMUST00000213877.2 Or1i2 ENSMUST00000213877.2 Membrane ; Multi- pass membrane protein (from UniProt Q7TQU7) A0A0N4SVB6 ENSMUST00000213877.1 Olfr1357 Or1i2 Q7TQU7 Q7TQU7_MOUSE uc287sqj.1 uc287sqj.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287sqj.1 uc287sqj.2 
ENSMUST00000213883.2 Or4c15b ENSMUST00000213883.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQZ9) A3KGY9 ENSMUST00000213883.1 Olfr1229 Or4c15b Q7TQZ9 Q7TQZ9_MOUSE uc289ybw.1 uc289ybw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ybw.1 uc289ybw.2 
ENSMUST00000213885.2 Gm31374 ENSMUST00000213885.2 Gm31374 (from geneSymbol) ENSMUST00000213885.1 uc292gzb.1 uc292gzb.2 uc292gzb.1 uc292gzb.2 
ENSMUST00000213901.2 Gm49783 ENSMUST00000213901.2 Gm49783 (from geneSymbol) AK084348 ENSMUST00000213901.1 uc287udm.1 uc287udm.2 uc287udm.1 uc287udm.2 
ENSMUST00000213903.2 Or11g25 ENSMUST00000213903.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N1Y5) ENSMUST00000213903.1 L7N1Y5 L7N1Y5_MOUSE Olfr741 Or11g25 uc288tlp.1 uc288tlp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tlp.1 uc288tlp.2 
ENSMUST00000213905.2 Gm47121 ENSMUST00000213905.2 Gm47121 (from geneSymbol) ENSMUST00000213905.1 uc292mlm.1 uc292mlm.2 uc292mlm.1 uc292mlm.2 
ENSMUST00000213906.2 Or52ae9 ENSMUST00000213906.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q0VBH3) ENSMUST00000213906.1 Olfr629 Or52ae9 Q0VBH3 Q0VBH3_MOUSE uc291trs.1 uc291trs.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291trs.1 uc291trs.2 
ENSMUST00000213907.2 Gm48293 ENSMUST00000213907.2 Gm48293 (from geneSymbol) ENSMUST00000213907.1 uc292geo.1 uc292geo.2 uc292geo.1 uc292geo.2 
ENSMUST00000213909.3 Or4c126 ENSMUST00000213909.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFB0) A0A1L1STI7 ENSMUST00000213909.1 ENSMUST00000213909.2 GO3 Olfr1261 Or4c126 Q8VFB0 Q8VFB0_MOUSE uc289yeg.1 uc289yeg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yeg.1 uc289yeg.2 
ENSMUST00000213910.2 Or5ac23 ENSMUST00000213910.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TS37) ENSMUST00000213910.1 F6WLI2 Olfr203 Olfr205 Or5ac23 Q7TS37 Q7TS37_MOUSE uc007zpc.1 uc007zpc.2 uc007zpc.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007zpc.1 uc007zpc.2 uc007zpc.3 
ENSMUST00000213911.2 Gm47176 ENSMUST00000213911.2 Gm47176 (from geneSymbol) ENSMUST00000213911.1 uc292hlt.1 uc292hlt.2 uc292hlt.1 uc292hlt.2 
ENSMUST00000213912.2 Or2w2 ENSMUST00000213912.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5SZS9) ENSMUST00000213912.1 Olfr1364 Or2w2 Q5SZS9 Q5SZS9_MOUSE uc288lfh.1 uc288lfh.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288lfh.1 uc288lfh.2 
ENSMUST00000213918.2 Or2ag2 ENSMUST00000213918.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EPF8) ENSMUST00000213918.1 Olfr706 Or2ag2 Q9EPF8 Q9EPF8_MOUSE uc009jak.1 uc009jak.2 uc009jak.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jak.1 uc009jak.2 uc009jak.3 
ENSMUST00000213920.2 Gm47141 ENSMUST00000213920.2 Gm47141 (from geneSymbol) ENSMUST00000213920.1 uc292gze.1 uc292gze.2 uc292gze.1 uc292gze.2 
ENSMUST00000213921.2 Gm47604 ENSMUST00000213921.2 Gm47604 (from geneSymbol) ENSMUST00000213921.1 uc292jhz.1 uc292jhz.2 uc292jhz.1 uc292jhz.2 
ENSMUST00000213925.2 Or5b98 ENSMUST00000213925.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF19) ENSMUST00000213925.1 Olfr1450 Or5b98 Q8VF19 Q8VF19_MOUSE uc289rdu.1 uc289rdu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rdu.1 uc289rdu.2 
ENSMUST00000213928.2 Or4d2b ENSMUST00000213928.2 Membrane ; Multi- pass membrane protein (from UniProt Q5SW50) ENSMUST00000213928.1 Olfr462 Or4d2b Q5SW50 Q5SW50_MOUSE uc288bfw.1 uc288bfw.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288bfw.1 uc288bfw.2 
ENSMUST00000213934.2 Gm48654 ENSMUST00000213934.2 Gm48654 (from geneSymbol) ENSMUST00000213934.1 uc287pkt.1 uc287pkt.2 uc287pkt.1 uc287pkt.2 
ENSMUST00000213937.2 AI593442 ENSMUST00000213937.2 expressed sequence AI593442, transcript variant 1 (from RefSeq NM_001286641.1) CK087_MOUSE ENSMUST00000213937.1 NM_001286641 Q32M26 Q8CC42 uc033jkl.1 uc033jkl.2 uc033jkl.3 Membrane ; Single-pass type I membrane protein Sequence=BAC28535.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process membrane integral component of membrane uc033jkl.1 uc033jkl.2 uc033jkl.3 
ENSMUST00000213940.2 Or2z9 ENSMUST00000213940.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q4J3) E9Q4J3 E9Q4J3_MOUSE ENSMUST00000213940.1 Olfr373 Or2z9 uc292azd.1 uc292azd.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292azd.1 uc292azd.2 
ENSMUST00000213941.2 Gm47983 ENSMUST00000213941.2 Gm47983 (from geneSymbol) ENSMUST00000213941.1 uc292kcm.1 uc292kcm.2 uc292kcm.1 uc292kcm.2 
ENSMUST00000213942.3 Or52e15 ENSMUST00000213942.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG28) ENSMUST00000213942.1 ENSMUST00000213942.2 Olfr672 Or52e15 Q8VG28 Q8VG28_MOUSE uc291tvu.1 uc291tvu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tvu.1 uc291tvu.2 
ENSMUST00000213948.2 5033425B01Rik ENSMUST00000213948.2 5033425B01Rik (from geneSymbol) AK017191 ENSMUST00000213948.1 uc292fmu.1 uc292fmu.2 uc292fmu.1 uc292fmu.2 
ENSMUST00000213953.2 Or6f2 ENSMUST00000213953.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRU1) ENSMUST00000213953.1 Olfr523 Or6f2 Q7TRU1 Q7TRU1_MOUSE uc291wtk.1 uc291wtk.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291wtk.1 uc291wtk.2 
ENSMUST00000213956.2 Or8b9 ENSMUST00000213956.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF62) ENSMUST00000213956.1 Olfr877 Or8b9 Q8VF62 Q8VF62_MOUSE uc292fwo.1 uc292fwo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fwo.1 uc292fwo.2 
ENSMUST00000213960.2 Chrna5 ENSMUST00000213960.2 cholinergic receptor, nicotinic, alpha polypeptide 5, transcript variant 1 (from RefSeq NM_001373901.1) ACHA5_MOUSE ENSMUST00000213960.1 NM_001373901 Q2MKA5 Q6PW45 uc009prw.1 uc009prw.2 uc009prw.3 uc009prw.4 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Interacts with LYPD6. Postsynaptic cell membrane ; Multi- pass membrane protein Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2MKA5-1; Sequence=Displayed; Name=2; IsoId=Q2MKA5-2; Sequence=VSP_028132; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub- subfamily. transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity plasma membrane integral component of plasma membrane acetylcholine-gated channel complex ion transport signal transduction chemical synaptic transmission synaptic transmission, cholinergic neuromuscular synaptic transmission acetylcholine receptor activity membrane integral component of membrane acetylcholine-gated cation-selective channel activity cell junction dendrite ion transmembrane transport response to nicotine behavioral response to nicotine acetylcholine binding regulation of membrane potential neuron projection neuronal cell body synapse postsynaptic membrane protein heterodimerization activity neurological system process regulation of postsynaptic membrane potential excitatory postsynaptic potential regulation of synaptic vesicle exocytosis uc009prw.1 uc009prw.2 uc009prw.3 uc009prw.4 
ENSMUST00000213961.3 Or4f59 ENSMUST00000213961.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF10) ENSMUST00000213961.1 ENSMUST00000213961.2 Olfr1312 Or4f59 Q8VF10 Q8VF10_MOUSE uc289zgq.1 uc289zgq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zgq.1 uc289zgq.2 
ENSMUST00000213965.3 Gm48061 ENSMUST00000213965.3 Gm48061 (from geneSymbol) ENSMUST00000213965.1 ENSMUST00000213965.2 uc287qxu.1 uc287qxu.2 uc287qxu.3 uc287qxu.1 uc287qxu.2 uc287qxu.3 
ENSMUST00000213968.2 Or4b13 ENSMUST00000213968.2 Odorant receptor. (from UniProt Q60881) ENSMUST00000213968.1 Mor227-2 O4B13_MOUSE Olfr142 Olfr4 Or4b13 Q60881 Q8VGP2 uc289yfk.1 uc289yfk.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yfk.1 uc289yfk.2 
ENSMUST00000213969.2 Or1l4 ENSMUST00000213969.2 Membrane ; Multi- pass membrane protein (from UniProt Q8VFT2) ENSMUST00000213969.1 Olfr365 Or1l4 Q8VFT2 Q8VFT2_MOUSE uc289vqp.1 uc289vqp.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vqp.1 uc289vqp.2 
ENSMUST00000213970.2 Or6c6 ENSMUST00000213970.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRI2) ENSMUST00000213970.1 Olfr782 Olfr804 Or6c6 Q7TRI2 Q7TRI2_MOUSE uc287vxq.1 uc287vxq.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vxq.1 uc287vxq.2 
ENSMUST00000213973.2 Gm31562 ENSMUST00000213973.2 Gm31562 (from geneSymbol) ENSMUST00000213973.1 uc287qoq.1 uc287qoq.2 uc287qoq.1 uc287qoq.2 
ENSMUST00000213974.2 5830454E08Rik ENSMUST00000213974.2 RIKEN cDNA 5830454E08 gene (from RefSeq NR_073359.1) ENSMUST00000213974.1 NR_073359 uc033jns.1 uc033jns.2 uc033jns.3 uc033jns.1 uc033jns.2 uc033jns.3 
ENSMUST00000213976.2 4921534A09Rik ENSMUST00000213976.2 4921534A09Rik (from geneSymbol) AK084767 ENSMUST00000213976.1 uc292evs.1 uc292evs.2 uc292evs.1 uc292evs.2 
ENSMUST00000213979.3 Or5p81 ENSMUST00000213979.3 olfactory receptor family 5 subfamily P member 81 (from RefSeq NM_146311.2) ENSMUST00000213979.1 ENSMUST00000213979.2 Mor204-34 NM_146311 O5P81_MOUSE Olfr510 Or5p81 Q8VEW6 uc291uhm.1 uc291uhm.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DR065926.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uhm.1 uc291uhm.2 
ENSMUST00000213982.2 Gm47633 ENSMUST00000213982.2 Gm47633 (from geneSymbol) AK086525 ENSMUST00000213982.1 uc292ful.1 uc292ful.2 uc292ful.1 uc292ful.2 
ENSMUST00000213984.2 Or52u1 ENSMUST00000213984.2 Membrane ; Multi- pass membrane protein (from UniProt Q7TRP9) ENSMUST00000213984.1 Olfr654 Or52u1 Q7TRP9 Q7TRP9_MOUSE uc291tuk.1 uc291tuk.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tuk.1 uc291tuk.2 
ENSMUST00000213987.3 Or8k1 ENSMUST00000213987.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR79) ENSMUST00000213987.1 ENSMUST00000213987.2 Olfr1046 Or8k1 Q7TR79 Q7TR79_MOUSE uc289xrf.1 uc289xrf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xrf.1 uc289xrf.2 
ENSMUST00000213988.2 Or1j1 ENSMUST00000213988.2 Odorant receptor. (from UniProt Q60879) ENSMUST00000213988.1 Mor136-14 OR1J1_MOUSE Olfr3 Or1j1 Q60879 Q8VFP7 uc289vpo.1 uc289vpo.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vpo.1 uc289vpo.2 
ENSMUST00000213989.2 Or13c25 ENSMUST00000213989.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGA0) B1AWZ7 ENSMUST00000213989.1 Olfr272 Or13c25 Q8VGA0 Q8VGA0_MOUSE uc290mst.1 uc290mst.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc290mst.1 uc290mst.2 
ENSMUST00000213990.2 Gnb5 ENSMUST00000213990.2 guanine nucleotide binding protein (G protein), beta 5, transcript variant 1 (from RefSeq NM_010313.2) ENSMUST00000213990.1 GNB5_MOUSE NM_010313 O35354 P54314 P62881 Q91WB3 uc009qry.1 uc009qry.2 uc009qry.3 uc009qry.4 Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (By similarity). Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). Component of a complex composed of RGS9 (isoform RGS9-1), GNB5 and RGS9BP; within this complex, the presence of GNB5 stabilizes both itself and RGS9 and increases RGS9 GTPase-activating protein (GAP) activity (PubMed:12119397, PubMed:16908407, PubMed:18204463). Interacts with RGS7, forming the RGS7-GNB5 complex; within this complex, the presence of GNB5 increases RGS7 GTPase-activating protein (GAP) activity (PubMed:31311860, PubMed:34793198). Interacts with GPR158; promotes the GTPase activator activity of the RGS7-GNB5 complex in absence of glycine, in contrast GTPase activator activity of the RGS7- GNB5 complex is inhibited in presence of glycine (PubMed:31311860, PubMed:34793198). Interacts with RGS6 (By similarity). Membrane Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long, Beta-5L, Gbeta5L; IsoId=P62881-1, P54314-1; Sequence=Displayed; Name=2; IsoId=P62881-2, P54314-2; Sequence=VSP_008766; Isoform 1 is only detected in retina (PubMed:8910430). Isoform 2 is detected in brain (at protein level) (PubMed:8071339). Isoform 2 is detected in brain (PubMed:8071339). Belongs to the WD repeat G protein beta family. photoreceptor outer segment photoreceptor inner segment GTPase activator activity protein binding nucleus cytosol plasma membrane signal transduction G-protein coupled receptor signaling pathway dopamine receptor signaling pathway membrane G-protein gamma-subunit binding GTPase activating protein binding macromolecular complex myelin sheath positive regulation of GTPase activity cell body chaperone binding presynapse negative regulation of voltage-gated calcium channel activity uc009qry.1 uc009qry.2 uc009qry.3 uc009qry.4 
ENSMUST00000213991.2 Or51a43 ENSMUST00000213991.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VH21) ENSMUST00000213991.1 Olfr644 Or51a43 Q8VH21 Q8VH21_MOUSE uc291tsv.1 uc291tsv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tsv.1 uc291tsv.2 
ENSMUST00000213994.3 Or4x15 ENSMUST00000213994.3 olfactory receptor family 4 subfamily X member 15 (from RefSeq NM_146265.2) A2ATW2 A2ATW2_MOUSE D3Z4B7 ENSMUST00000213994.1 ENSMUST00000213994.2 Gm13769 NM_146265 Olfr1506 Olfr1565 Or4x15 Or4x18 uc012byw.1 uc012byw.2 uc012byw.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc012byw.1 uc012byw.2 uc012byw.3 
ENSMUST00000213997.2 Or2f1 ENSMUST00000213997.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRV7) ENSMUST00000213997.1 Olfr453 Or2f1 Q7TRV7 Q7TRV7_MOUSE uc291dyt.1 uc291dyt.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dyt.1 uc291dyt.2 
ENSMUST00000213998.2 Or8k24 ENSMUST00000213998.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR74) ENSMUST00000213998.1 Olfr1058 Or8k24 Q7TR74 Q7TR74_MOUSE uc289xrw.1 uc289xrw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xrw.1 uc289xrw.2 
ENSMUST00000214002.2 Or5t17 ENSMUST00000214002.2 Potential odorant receptor. (from UniProt Q8VES2) A2AVB4 ENSMUST00000214002.1 Mor179-4 O5T17_MOUSE Olfr1102 Or5t17 Q8VES2 uc289xtm.1 uc289xtm.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xtm.1 uc289xtm.2 
ENSMUST00000214014.2 Gm47557 ENSMUST00000214014.2 Gm47557 (from geneSymbol) ENSMUST00000214014.1 uc292emi.1 uc292emi.2 uc292emi.1 uc292emi.2 
ENSMUST00000214016.2 4930553I21Rik ENSMUST00000214016.2 4930553I21Rik (from geneSymbol) AK016106 ENSMUST00000214016.1 uc287pky.1 uc287pky.2 uc287pky.1 uc287pky.2 
ENSMUST00000214021.3 Or52r1b ENSMUST00000214021.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRS2) ENSMUST00000214021.1 ENSMUST00000214021.2 Olfr582 Olfr584 Or52r1b Q7TRS2 Q7TRS2_MOUSE uc291toy.1 uc291toy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291toy.1 uc291toy.2 
ENSMUST00000214022.3 Or4c112 ENSMUST00000214022.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGG1) ENSMUST00000214022.1 ENSMUST00000214022.2 Olfr1217 Or4c112 Q8VGG1 Q8VGG1_MOUSE uc289yak.1 uc289yak.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yak.1 uc289yak.2 
ENSMUST00000214033.3 Gm47568 ENSMUST00000214033.3 Gm47568 (from geneSymbol) ENSMUST00000214033.1 ENSMUST00000214033.2 uc287qzw.1 uc287qzw.2 uc287qzw.3 uc287qzw.1 uc287qzw.2 uc287qzw.3 
ENSMUST00000214034.2 Gm47598 ENSMUST00000214034.2 Gm47598 (from geneSymbol) ENSMUST00000214034.1 LF270978 uc287qqm.1 uc287qqm.2 uc287qqm.1 uc287qqm.2 
ENSMUST00000214037.2 Gm49759 ENSMUST00000214037.2 Gm49759 (from geneSymbol) ENSMUST00000214037.1 uc292hvm.1 uc292hvm.2 uc292hvm.1 uc292hvm.2 
ENSMUST00000214040.3 Or4p7 ENSMUST00000214040.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR20) ENSMUST00000214040.1 ENSMUST00000214040.2 Olfr1178 Or4p7 Q7TR20 Q7TR20_MOUSE uc289xyb.1 uc289xyb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xyb.1 uc289xyb.2 
ENSMUST00000214041.2 Slfn3 ENSMUST00000214041.2 Slfn3 (from geneSymbol) A0A1L1STQ7 A0A1L1STQ7_MOUSE BC145134 ENSMUST00000214041.1 Slfn3 uc011ybe.1 uc011ybe.2 uc011ybe.3 negative regulation of cell proliferation uc011ybe.1 uc011ybe.2 uc011ybe.3 
ENSMUST00000214047.2 Gm48865 ENSMUST00000214047.2 Gm48865 (from geneSymbol) AK083708 ENSMUST00000214047.1 uc287qjl.1 uc287qjl.2 uc287qjl.1 uc287qjl.2 
ENSMUST00000214048.3 Or1p1 ENSMUST00000214048.3 olfactory receptor family 1 subfamily P member 1, transcript variant 1 (from RefSeq NM_011002.3) B1ARL2 B1ARL3 B1ARL3_MOUSE ENSMUST00000214048.1 ENSMUST00000214048.2 NM_011002 Olfr59 Or1p1 uc007kbr.1 uc007kbr.2 uc007kbr.3 uc007kbr.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DR065551.1, DR065639.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007kbr.1 uc007kbr.2 uc007kbr.3 uc007kbr.4 
ENSMUST00000214049.2 Or5aq1b ENSMUST00000214049.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AVB8) A2AVB8 A2AVB8_MOUSE ENSMUST00000214049.1 Olfr1107 Or5aq1b uc289xtt.1 uc289xtt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xtt.1 uc289xtt.2 
ENSMUST00000214051.2 Or52e3 ENSMUST00000214051.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRR4) ENSMUST00000214051.1 Olfr594 Or52e3 Q7TRR4 Q7TRR4_MOUSE uc009itj.1 uc009itj.2 uc009itj.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009itj.1 uc009itj.2 uc009itj.3 
ENSMUST00000214052.2 Or8g19 ENSMUST00000214052.2 olfactory receptor family 8 subfamily G member 19 (from RefSeq NM_146829.2) ENSMUST00000214052.1 NM_146829 Olfr27 Or8g19 Q9EQ90 Q9EQ90_MOUSE uc009oxq.1 uc009oxq.2 uc009oxq.3 uc009oxq.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB174475.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oxq.1 uc009oxq.2 uc009oxq.3 uc009oxq.4 
ENSMUST00000214055.2 Gm48092 ENSMUST00000214055.2 Gm48092 (from geneSymbol) ENSMUST00000214055.1 LF197953 uc287qjq.1 uc287qjq.2 uc287qjq.1 uc287qjq.2 
ENSMUST00000214056.2 Plekhg4 ENSMUST00000214056.2 pleckstrin homology domain containing, family G (with RhoGef domain) member 4, transcript variant 2 (from RefSeq NM_001364406.1) A0A1L1SU27 A0A1L1SU27_MOUSE ENSMUST00000214056.1 NM_001364406 Plekhg4 uc292cuy.1 uc292cuy.2 molecular_function Rho guanyl-nucleotide exchange factor activity cellular_component regulation of Rho protein signal transduction uc292cuy.1 uc292cuy.2 
ENSMUST00000214060.2 Gm34069 ENSMUST00000214060.2 Gm34069 (from geneSymbol) ENSMUST00000214060.1 uc292emq.1 uc292emq.2 uc292emq.1 uc292emq.2 
ENSMUST00000214063.2 Or4f62 ENSMUST00000214063.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQW6) ENSMUST00000214063.1 Olfr1318 Or4f62 Q7TQW6 Q7TQW6_MOUSE uc289zhf.1 uc289zhf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zhf.1 uc289zhf.2 
ENSMUST00000214064.2 Or6c208 ENSMUST00000214064.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFZ9) ENSMUST00000214064.1 Olfr784 Or6c208 Q8VFZ9 Q8VFZ9_MOUSE uc287vxs.1 uc287vxs.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vxs.1 uc287vxs.2 
ENSMUST00000214070.3 Gm48671 ENSMUST00000214070.3 Gm48671 (from geneSymbol) ENSMUST00000214070.1 ENSMUST00000214070.2 uc287qvl.1 uc287qvl.2 uc287qvl.3 uc287qvl.1 uc287qvl.2 uc287qvl.3 
ENSMUST00000214073.2 Gm48832 ENSMUST00000214073.2 Gm48832 (from geneSymbol) ENSMUST00000214073.1 uc292jhg.1 uc292jhg.2 uc292jhg.1 uc292jhg.2 
ENSMUST00000214076.2 Gm47427 ENSMUST00000214076.2 Gm47427 (from geneSymbol) ENSMUST00000214076.1 uc292kdv.1 uc292kdv.2 uc292kdv.1 uc292kdv.2 
ENSMUST00000214079.2 Or5b24 ENSMUST00000214079.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEV8) ENSMUST00000214079.1 Olfr1449 Or5b24 Q8VEV8 Q8VEV8_MOUSE uc008guy.1 uc008guy.2 uc008guy.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008guy.1 uc008guy.2 uc008guy.3 
ENSMUST00000214083.3 Gm47070 ENSMUST00000214083.3 Gm47070 (from geneSymbol) ENSMUST00000214083.1 ENSMUST00000214083.2 uc292mgn.1 uc292mgn.2 uc292mgn.3 uc292mgn.1 uc292mgn.2 uc292mgn.3 
ENSMUST00000214085.2 Gm47144 ENSMUST00000214085.2 Gm47144 (from geneSymbol) ENSMUST00000214085.1 uc292gzf.1 uc292gzf.2 uc292gzf.1 uc292gzf.2 
ENSMUST00000214088.2 Gm47674 ENSMUST00000214088.2 Gm47674 (from geneSymbol) AK156140 ENSMUST00000214088.1 uc292fgo.1 uc292fgo.2 uc292fgo.1 uc292fgo.2 
ENSMUST00000214091.3 Gm39464 ENSMUST00000214091.3 Gm39464 (from geneSymbol) ENSMUST00000214091.1 ENSMUST00000214091.2 uc292mlc.1 uc292mlc.2 uc292mlc.3 uc292mlc.1 uc292mlc.2 uc292mlc.3 
ENSMUST00000214092.2 Gm48233 ENSMUST00000214092.2 Gm48233 (from geneSymbol) AK145502 ENSMUST00000214092.1 uc287qie.1 uc287qie.2 uc287qie.1 uc287qie.2 
ENSMUST00000214093.3 Or8b51 ENSMUST00000214093.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG53) E9PWU3 E9Q2U3 E9Q338 ENSMUST00000214093.1 ENSMUST00000214093.2 Olfr904 Olfr916 Or8b51 Q8VG53 Q8VG53_MOUSE uc292fyo.1 uc292fyo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fyo.1 uc292fyo.2 
ENSMUST00000214098.2 Gramd1c ENSMUST00000214098.2 GRAM domain containing 1C, transcript variant 4 (from RefSeq NM_001408334.1) A0A1L1SSU1 ASTRC_MOUSE ENSMUST00000214098.1 NM_001408334 Q8BI24 Q8CI52 uc289ett.1 uc289ett.2 Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461). Endoplasmic reticulum membrane ; Single-pass membrane protein Cell membrane ; Single-pass membrane protein Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS). Highly expressed in the liver. Also found in the testis. GRAM domain binds phosphatidylserine in the PM and mediates protein recruitment to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM. VASt (VAD1 Analog of StAR-related lipid transfer) domain, also known as ASTER (Greek for star) domain is a sterol-binding domain. Sequence=AAH37472.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC26506.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; endoplasmic reticulum endoplasmic reticulum membrane plasma membrane lipid transport lipid binding cholesterol binding sterol transport membrane integral component of membrane cellular response to cholesterol uc289ett.1 uc289ett.2 
ENSMUST00000214099.2 Or52d1 ENSMUST00000214099.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGW2) ENSMUST00000214099.1 Olfr646 Or52d1 Q8VGW2 Q8VGW2_MOUSE uc291tsx.1 uc291tsx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tsx.1 uc291tsx.2 
ENSMUST00000214103.2 Or4d6 ENSMUST00000214103.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q0VDY1) ENSMUST00000214103.1 Olfr1428 Or4d6 Q0VDY1 Q0VDY1_MOUSE uc289ray.1 uc289ray.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ray.1 uc289ray.2 
ENSMUST00000214104.2 Gm34424 ENSMUST00000214104.2 predicted gene, 34424 (from RefSeq NR_175873.1) ENSMUST00000214104.1 NR_175873 uc292hyi.1 uc292hyi.2 uc292hyi.1 uc292hyi.2 
ENSMUST00000214107.3 1700054O05Rik ENSMUST00000214107.3 1700054O05Rik (from geneSymbol) AK006787 ENSMUST00000214107.1 ENSMUST00000214107.2 uc287qmw.1 uc287qmw.2 uc287qmw.3 uc287qmw.1 uc287qmw.2 uc287qmw.3 
ENSMUST00000214108.2 Gm33914 ENSMUST00000214108.2 Gm33914 (from geneSymbol) ENSMUST00000214108.1 uc292hxo.1 uc292hxo.2 uc292hxo.1 uc292hxo.2 
ENSMUST00000214109.2 Or6c205 ENSMUST00000214109.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRI4) ENSMUST00000214109.1 Olfr775 Olfr776 Or6c205 Q7TRI4 Q7TRI4_MOUSE uc287vxh.1 uc287vxh.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vxh.1 uc287vxh.2 
ENSMUST00000214113.2 Gm36799 ENSMUST00000214113.2 Gm36799 (from geneSymbol) AK039939 ENSMUST00000214113.1 uc292gjv.1 uc292gjv.2 uc292gjv.1 uc292gjv.2 
ENSMUST00000214117.2 Il18 ENSMUST00000214117.2 interleukin 18, transcript variant 1 (from RefSeq NM_008360.2) ENSMUST00000214117.1 Il18 NM_008360 Q2PMY2 Q2PMY2_MOUSE uc009pju.1 uc009pju.2 uc009pju.3 Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin- 12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. Secreted Belongs to the IL-1 family. MAPK cascade angiogenesis cytokine activity extracellular region extracellular space inflammatory response immune response positive regulation of phosphatidylinositol 3-kinase signaling regulation of cell adhesion lipopolysaccharide-mediated signaling pathway activation of protein kinase B activity positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-17 production positive regulation of natural killer cell proliferation interleukin-18-mediated signaling pathway T-helper 1 type immune response positive regulation of activated T cell proliferation positive regulation of tyrosine phosphorylation of STAT protein interleukin-18 receptor binding positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle cell proliferation positive regulation of NF-kappaB transcription factor activity positive regulation of NK T cell proliferation positive regulation of protein kinase B signaling cellular response to organic cyclic compound positive regulation of T-helper 1 cell cytokine production uc009pju.1 uc009pju.2 uc009pju.3 
ENSMUST00000214119.2 Or10ag53 ENSMUST00000214119.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR53) ENSMUST00000214119.1 Olfr1115 Or10ag53 Q7TR53 Q7TR53_MOUSE uc289xuk.1 uc289xuk.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xuk.1 uc289xuk.2 
ENSMUST00000214120.2 Gm48822 ENSMUST00000214120.2 Gm48822 (from geneSymbol) AK034865 ENSMUST00000214120.1 uc292iwg.1 uc292iwg.2 uc292iwg.1 uc292iwg.2 
ENSMUST00000214121.2 Or4p8 ENSMUST00000214121.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG47) ENSMUST00000214121.1 Olfr1208 Or4p8 Q8VG47 Q8VG47_MOUSE uc289xzu.1 uc289xzu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xzu.1 uc289xzu.2 
ENSMUST00000214129.2 Gm40634 ENSMUST00000214129.2 Gm40634 (from geneSymbol) ENSMUST00000214129.1 uc287qwz.1 uc287qwz.2 uc287qwz.1 uc287qwz.2 
ENSMUST00000214130.2 Or7g32 ENSMUST00000214130.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRG0) ENSMUST00000214130.1 Olfr851 Or7g32 Q7TRG0 Q7TRG0_MOUSE uc292ety.1 uc292ety.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292ety.1 uc292ety.2 
ENSMUST00000214132.2 Or11l3 ENSMUST00000214132.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5NCD0) ENSMUST00000214132.1 Olfr323 Or11l3 Q5NCD0 Q5NCD0_MOUSE uc287ykk.1 uc287ykk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ykk.1 uc287ykk.2 
ENSMUST00000214133.2 Gm49661 ENSMUST00000214133.2 Gm49661 (from geneSymbol) A0A1L1STL9 A0A1L1STL9_MOUSE ENSMUST00000214133.1 Gm49661 uc292bqm.1 uc292bqm.2 uc292bqm.1 uc292bqm.2 
ENSMUST00000214139.2 Or5k1b ENSMUST00000214139.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q8F6) E9Q8F6 E9Q8F6_MOUSE ENSMUST00000214139.1 Olfr172 Or5k1b uc289ffe.1 uc289ffe.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ffe.1 uc289ffe.2 
ENSMUST00000214141.2 Or8k3b ENSMUST00000214141.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR63) ENSMUST00000214141.1 Olfr1087 Or8k3b Q7TR63 Q7TR63_MOUSE uc289xsx.1 uc289xsx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xsx.1 uc289xsx.2 
ENSMUST00000214152.2 Or4k6 ENSMUST00000214152.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt F8VQB9) ENSMUST00000214152.1 F8VQB9 F8VQB9_MOUSE Olfr731 Or4k6 uc288tky.1 uc288tky.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tky.1 uc288tky.2 
ENSMUST00000214157.2 Or8g21 ENSMUST00000214157.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG16) ENSMUST00000214157.1 Olfr919 Olfr935 Or8g21 Q8VG16 Q8VG16_MOUSE uc292fzv.1 uc292fzv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fzv.1 uc292fzv.2 
ENSMUST00000214163.2 Gm47049 ENSMUST00000214163.2 Gm47049 (from geneSymbol) ENSMUST00000214163.1 uc287qna.1 uc287qna.2 uc287qna.1 uc287qna.2 
ENSMUST00000214168.2 Or10g1b ENSMUST00000214168.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PWU0) E9PWU0 E9PWU0_MOUSE ENSMUST00000214168.1 Olfr1511 Or10g1b uc288tvl.1 uc288tvl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tvl.1 uc288tvl.2 
ENSMUST00000214173.2 Or51ab3 ENSMUST00000214173.2 Membrane ; Multi- pass membrane protein (from UniProt E9PYB4) E9PYB4 E9PYB4_MOUSE ENSMUST00000214173.1 Olfr613 Or51ab3 uc291tqu.1 uc291tqu.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tqu.1 uc291tqu.2 
ENSMUST00000214177.2 Or6c74 ENSMUST00000214177.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG45) ENSMUST00000214177.1 Olfr821 Or6c74 Q8VG45 Q8VG45_MOUSE uc287wah.1 uc287wah.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287wah.1 uc287wah.2 
ENSMUST00000214180.2 Or13a18 ENSMUST00000214180.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRT4) ENSMUST00000214180.1 Olfr46 Or13a18 Q7TRT4 Q7TRT4_MOUSE uc291wvh.1 uc291wvh.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291wvh.1 uc291wvh.2 
ENSMUST00000214186.2 Or5ac17 ENSMUST00000214186.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt F6ZUS0) ENSMUST00000214186.1 F6ZUS0 F6ZUS0_MOUSE Olfr199 Olfr202 Or5ac17 uc007zox.1 uc007zox.2 uc007zox.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007zox.1 uc007zox.2 uc007zox.3 
ENSMUST00000214192.2 Or9r7 ENSMUST00000214192.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFU4) ENSMUST00000214192.1 Olfr824 Or9r7 Q8VFU4 Q8VFU4_MOUSE uc287wan.1 uc287wan.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287wan.1 uc287wan.2 
ENSMUST00000214195.3 Or2t26 ENSMUST00000214195.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGD7) A0A0N4SW38 ENSMUST00000214195.1 ENSMUST00000214195.2 Olfr1395 Or2t26 Q8VGD7 Q8VGD7_MOUSE uc287xsk.1 uc287xsk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xsk.1 uc287xsk.2 
ENSMUST00000214196.2 Gm32743 ENSMUST00000214196.2 Gm32743 (from geneSymbol) ENSMUST00000214196.1 uc292kfr.1 uc292kfr.2 uc292kfr.1 uc292kfr.2 
ENSMUST00000214199.4 Gm32468 ENSMUST00000214199.4 Gm32468 (from geneSymbol) ENSMUST00000214199.1 ENSMUST00000214199.2 ENSMUST00000214199.3 uc287udx.1 uc287udx.2 uc287udx.3 uc287udx.4 uc287udx.1 uc287udx.2 uc287udx.3 uc287udx.4 
ENSMUST00000214203.2 Gm49628 ENSMUST00000214203.2 Gm49628 (from geneSymbol) AK080677 ENSMUST00000214203.1 uc287ufx.1 uc287ufx.2 uc287ufx.1 uc287ufx.2 
ENSMUST00000214207.2 Or5d45 ENSMUST00000214207.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BRN4) A0A2I3BRN4 A0A2I3BRN4_MOUSE ENSMUST00000214207.1 Olfr1175 Olfr1175-ps Or5d45 uc289xxx.1 uc289xxx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxx.1 uc289xxx.2 
ENSMUST00000214209.2 Or5w14 ENSMUST00000214209.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR40) ENSMUST00000214209.1 Olfr1137 Or5w14 Q7TR40 Q7TR40_MOUSE uc289xwd.1 uc289xwd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xwd.1 uc289xwd.2 
ENSMUST00000214210.2 Or1e17 ENSMUST00000214210.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRX4) ENSMUST00000214210.1 Olfr23 Or1e17 Q7TRX4 Q7TRX4_MOUSE uc288aao.1 uc288aao.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288aao.1 uc288aao.2 
ENSMUST00000214214.2 Or9s18 ENSMUST00000214214.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q2B9) E9Q2B9 E9Q2B9_MOUSE ENSMUST00000214214.1 Olfr466 Or9s18 uc288nxo.1 uc288nxo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288nxo.1 uc288nxo.2 
ENSMUST00000214215.2 Or52r1c ENSMUST00000214215.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRS0) ENSMUST00000214215.1 Olfr584 Or52r1c Q7TRS0 Q7TRS0_MOUSE uc009itc.1 uc009itc.2 uc009itc.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009itc.1 uc009itc.2 uc009itc.3 
ENSMUST00000214216.2 Or52e18 ENSMUST00000214216.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRP3) ENSMUST00000214216.1 Olfr670 Or52e18 Q7TRP3 Q7TRP3_MOUSE uc291tvr.1 uc291tvr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tvr.1 uc291tvr.2 
ENSMUST00000214228.2 Or1e25 ENSMUST00000214228.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRX8) ENSMUST00000214228.1 Olfr23 Olfr384 Olfr386 Or1e25 Q7TRX8 Q7TRX8_MOUSE uc287zzs.1 uc287zzs.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287zzs.1 uc287zzs.2 
ENSMUST00000214235.3 2010001M07Rik ENSMUST00000214235.3 2010001M07Rik (from geneSymbol) AK008015 ENSMUST00000214235.1 ENSMUST00000214235.2 uc292hwo.1 uc292hwo.2 uc292hwo.3 uc292hwo.1 uc292hwo.2 uc292hwo.3 
ENSMUST00000214237.2 Gm29825 ENSMUST00000214237.2 Gm29825 (from geneSymbol) ENSMUST00000214237.1 uc292lxp.1 uc292lxp.2 uc292lxp.1 uc292lxp.2 
ENSMUST00000214238.2 Or2c1 ENSMUST00000214238.2 Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanetiol (MTMT) (PubMed:29659735). Also binds odorants acetophenone and benzaldehyde (PubMed:25901328). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Probable). May be involved in the molecular processes underlying fasciculation and targeting of olfactory axons (PubMed:15342743). (from UniProt P23275) ENSMUST00000214238.1 Mor256-17 OR2C1_MOUSE Olfr15 Or2c1 P23275 Q496W6 Q8VFF0 uc289bzm.1 uc289bzm.2 Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanetiol (MTMT) (PubMed:29659735). Also binds odorants acetophenone and benzaldehyde (PubMed:25901328). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Probable). May be involved in the molecular processes underlying fasciculation and targeting of olfactory axons (PubMed:15342743). Cell membrane ulti-pass membrane protein Olfactory epithelium. Present in various subcellular compartments of the olfactory sensory neurons, particularly in the axonal processes and neve terminals. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane cell cortex signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception detection of chemical stimulus involved in sensory perception of smell uc289bzm.1 uc289bzm.2 
ENSMUST00000214239.2 Or9s23 ENSMUST00000214239.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGU3) ENSMUST00000214239.1 Olfr1413 Or9s23 Q8VGU3 Q8VGU3_MOUSE uc287kmb.1 uc287kmb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287kmb.1 uc287kmb.2 
ENSMUST00000214242.2 Or8g2b ENSMUST00000214242.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EQ96) ENSMUST00000214242.1 Olfr971 Or8g2b Q9EQ96 Q9EQ96_MOUSE uc292gci.1 uc292gci.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gci.1 uc292gci.2 
ENSMUST00000214251.3 Gm39363 ENSMUST00000214251.3 Gm39363 (from geneSymbol) ENSMUST00000214251.1 ENSMUST00000214251.2 uc292ies.1 uc292ies.2 uc292ies.3 uc292ies.1 uc292ies.2 uc292ies.3 
ENSMUST00000214253.2 Or5p5 ENSMUST00000214253.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRV2) ENSMUST00000214253.1 Olfr467 Or5p5 Q7TRV2 Q7TRV2_MOUSE uc291ufg.1 uc291ufg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ufg.1 uc291ufg.2 
ENSMUST00000214258.2 Gm47643 ENSMUST00000214258.2 Gm47643 (from geneSymbol) ENSMUST00000214258.1 uc292fuo.1 uc292fuo.2 uc292fuo.1 uc292fuo.2 
ENSMUST00000214259.2 Or5v1b ENSMUST00000214259.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRK1) ENSMUST00000214259.1 Olfr111 Or5v1b Q7TRK1 Q7TRK1_MOUSE uc289kzv.1 uc289kzv.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kzv.1 uc289kzv.2 
ENSMUST00000214260.2 Or52n5 ENSMUST00000214260.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGU9) ENSMUST00000214260.1 Olfr669 Or52n5 Q8VGU9 Q8VGU9_MOUSE uc291tvo.1 uc291tvo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tvo.1 uc291tvo.2 
ENSMUST00000214263.2 Or8b4 ENSMUST00000214263.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRE3) ENSMUST00000214263.1 Olfr878 Or8b4 Q7TRE3 Q7TRE3_MOUSE uc292fws.1 uc292fws.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fws.1 uc292fws.2 
ENSMUST00000214264.3 Or8b44 ENSMUST00000214264.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRC7) ENSMUST00000214264.1 ENSMUST00000214264.2 Olfr907 Or8b44 Q7TRC7 Q7TRC7_MOUSE uc292fyh.1 uc292fyh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fyh.1 uc292fyh.2 
ENSMUST00000214267.2 Or7g25 ENSMUST00000214267.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRG4) ENSMUST00000214267.1 Olfr843 Or7g25 Q7TRG4 Q7TRG4_MOUSE uc292etm.1 uc292etm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292etm.1 uc292etm.2 
ENSMUST00000214269.3 Or51aa2 ENSMUST00000214269.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N462) ENSMUST00000214269.1 ENSMUST00000214269.2 L7N462 L7N462_MOUSE Olfr612 Or51aa2 uc291tqt.1 uc291tqt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tqt.1 uc291tqt.2 
ENSMUST00000214271.2 Or6c202 ENSMUST00000214271.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFH6) ENSMUST00000214271.1 Olfr771 Or6c202 Q8VFH6 Q8VFH6_MOUSE uc287vxd.1 uc287vxd.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vxd.1 uc287vxd.2 
ENSMUST00000214281.2 Or13c7c ENSMUST00000214281.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9QZ20) ENSMUST00000214281.1 OR37C Olfr157 Or13c7c Q9QZ20 Q9QZ20_MOUSE or37c uc290mia.1 uc290mia.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc290mia.1 uc290mia.2 
ENSMUST00000214290.2 Or11h4 ENSMUST00000214290.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q438) E9Q438 E9Q438_MOUSE ENSMUST00000214290.1 Olfr749 Or11h4 uc033gpt.1 uc033gpt.2 uc033gpt.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033gpt.1 uc033gpt.2 uc033gpt.3 
ENSMUST00000214296.2 Or13a22 ENSMUST00000214296.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGL3) ENSMUST00000214296.1 Olfr535 Or13a22 Q8VGL3 Q8VGL3_MOUSE uc009kht.1 uc009kht.2 uc009kht.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009kht.1 uc009kht.2 uc009kht.3 
ENSMUST00000214299.2 Or51a10 ENSMUST00000214299.2 olfactory receptor family 51 subfamily A member 10 (from RefSeq NM_146329.1) ENSMUST00000214299.1 NM_146329 Olfr642 Or51a10 Q924X8 Q924X8_MOUSE uc291tst.1 uc291tst.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC126862.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tst.1 uc291tst.2 
ENSMUST00000214301.3 Or6z3 ENSMUST00000214301.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGH5) ENSMUST00000214301.1 ENSMUST00000214301.2 Olfr1336 Or6z3 Q8VGH5 Q8VGH5_MOUSE uc291lca.1 uc291lca.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291lca.1 uc291lca.2 
ENSMUST00000214304.2 Or4a78 ENSMUST00000214304.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQZ3) ENSMUST00000214304.1 Olfr1251 Or4a78 Q7TQZ3 Q7TQZ3_MOUSE uc289yde.1 uc289yde.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yde.1 uc289yde.2 
ENSMUST00000214307.3 Gm2449 ENSMUST00000214307.3 predicted gene 2449, transcript variant 2 (from RefSeq NR_190119.1) ENSMUST00000214307.1 ENSMUST00000214307.2 NR_190119 uc009sbl.1 uc009sbl.2 uc009sbl.3 uc009sbl.4 uc009sbl.1 uc009sbl.2 uc009sbl.3 uc009sbl.4 
ENSMUST00000214308.2 Gm47270 ENSMUST00000214308.2 Gm47270 (from geneSymbol) ENSMUST00000214308.1 uc292iff.1 uc292iff.2 uc292iff.1 uc292iff.2 
ENSMUST00000214315.2 Or2l5 ENSMUST00000214315.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGJ5) ENSMUST00000214315.1 Olfr167 Or2l5 Q8VGJ5 Q8VGJ5_MOUSE uc289dhm.1 uc289dhm.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289dhm.1 uc289dhm.2 
ENSMUST00000214317.2 Or8k39 ENSMUST00000214317.2 olfactory receptor family 8 subfamily K member 39 (from RefSeq NM_001011771.2) A0A1L1SRK6 A0A1L1SRK6_MOUSE ENSMUST00000214317.1 NM_001011771 Olfr1089 Or8k39 uc008kmv.1 uc008kmv.2 uc008kmv.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kmv.1 uc008kmv.2 uc008kmv.3 
ENSMUST00000214321.2 Or2w6 ENSMUST00000214321.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFH0) ENSMUST00000214321.1 Olfr1361 Or2w6 Q8VFH0 Q8VFH0_MOUSE uc288lfk.1 uc288lfk.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288lfk.1 uc288lfk.2 
ENSMUST00000214324.3 Or10d1c ENSMUST00000214324.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EQ87) ENSMUST00000214324.1 ENSMUST00000214324.2 Olfr934 Or10d1c Q9EQ87 Q9EQ87_MOUSE uc292fzu.1 uc292fzu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fzu.1 uc292fzu.2 
ENSMUST00000214329.3 Or52ab4 ENSMUST00000214329.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG01) ENSMUST00000214329.1 ENSMUST00000214329.2 Olfr599 Or52ab4 Q8VG01 Q8VG01_MOUSE uc009itn.1 uc009itn.2 uc009itn.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009itn.1 uc009itn.2 uc009itn.3 
ENSMUST00000214334.2 Or1r1 ENSMUST00000214334.2 Membrane ; Multi- pass membrane protein (from UniProt Q8VFY0) ENSMUST00000214334.1 Olfr398 Or1r1 Q8VFY0 Q8VFY0_MOUSE uc288aau.1 uc288aau.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288aau.1 uc288aau.2 
ENSMUST00000214337.2 Cfap97d2 ENSMUST00000214337.2 Belongs to the CFAP97 family. (from UniProt A0A286YE38) A0A286YE38 A0A286YE38_MOUSE AK038767 Cfap97d2 ENSMUST00000214337.1 uc291yke.1 uc291yke.2 Belongs to the CFAP97 family. uc291yke.1 uc291yke.2 
ENSMUST00000214340.2 Ackr2 ENSMUST00000214340.2 atypical chemokine receptor 2, transcript variant 1 (from RefSeq NM_001276719.1) ACKR2_MOUSE Ccbp2 D6 ENSMUST00000214340.1 NM_001276719 O08707 Q8CEG1 uc009see.1 uc009see.2 uc009see.3 uc009see.4 Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta- arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs. Early endosome Recycling endosome Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity). Expressed on apoptotic neutrophils (at protein level). The C-terminal cytoplasmic tail controls its phosphorylation, stability, intracellular trafficking itinerary, and chemokine scavenging properties. Phosphorylated on serine residues in the C-terminal cytoplasmic tail. Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily. G-protein coupled receptor activity chemokine receptor activity scavenger receptor activity protein binding nucleoplasm endosome early endosome cytosol actin filament plasma membrane integral component of plasma membrane endocytosis chemotaxis inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration external side of plasma membrane membrane integral component of membrane C-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding nuclear membrane intracellular membrane-bounded organelle recycling endosome cell chemotaxis chemokine-mediated signaling pathway uc009see.1 uc009see.2 uc009see.3 uc009see.4 
ENSMUST00000214343.2 Gm47160 ENSMUST00000214343.2 Gm47160 (from geneSymbol) AK044251 ENSMUST00000214343.1 uc292hab.1 uc292hab.2 uc292hab.1 uc292hab.2 
ENSMUST00000214344.3 Or8b1 ENSMUST00000214344.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N5P3) ENSMUST00000214344.1 ENSMUST00000214344.2 K7N5P3 K7N5P3_MOUSE Olfr906 Or8b1 uc292fyf.1 uc292fyf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fyf.1 uc292fyf.2 
ENSMUST00000214347.2 Or52d13 ENSMUST00000214347.2 olfactory receptor family 52 subfamily D member 13 (from RefSeq NM_001370895.1) A0A2I3BR67 A0A2I3BR67_MOUSE ENSMUST00000214347.1 NM_001370895 Olfr607 Or52d13 uc291tql.1 uc291tql.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tql.1 uc291tql.2 
ENSMUST00000214351.2 Or2b11 ENSMUST00000214351.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TS30) ENSMUST00000214351.1 Olfr222 Or2b11 Q5SXI8 Q7TS30 Q7TS30_MOUSE uc287ynh.1 uc287ynh.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ynh.1 uc287ynh.2 
ENSMUST00000214352.2 Gm32338 ENSMUST00000214352.2 Gm32338 (from geneSymbol) ENSMUST00000214352.1 uc287qrw.1 uc287qrw.2 uc287qrw.1 uc287qrw.2 
ENSMUST00000214356.3 Or4b1c ENSMUST00000214356.3 Or4b1c (from geneSymbol) ENSMUST00000214356.1 ENSMUST00000214356.2 uc289yfo.1 uc289yfo.2 uc289yfo.1 uc289yfo.2 
ENSMUST00000214357.2 Igsf9b ENSMUST00000214357.2 immunoglobulin superfamily, member 9B, transcript variant 2 (from RefSeq NM_001326702.1) A0A1L1SR84 A0A1L1SR84_MOUSE ENSMUST00000214357.1 Igsf9b NM_001326702 uc012gps.1 uc012gps.2 uc012gps.3 uc012gps.4 membrane integral component of membrane uc012gps.1 uc012gps.2 uc012gps.3 uc012gps.4 
ENSMUST00000214374.2 Ryr1 ENSMUST00000214374.2 Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671, ChEBI:CHEBI:29108; Evidence=; (from UniProt A0A1L1SQG7) A0A1L1SQG7 A0A1L1SQG7_MOUSE AY268935 ENSMUST00000214374.1 Ryr1 uc291nnu.1 uc291nnu.2 Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671, ChEBI:CHEBI:29108; Evidence=; Membrane ; Multi- pass membrane protein Sarcoplasmic reticulum membrane ; Multi-pass membrane protein ion channel activity ryanodine-sensitive calcium-release channel activity calcium channel activity calcium ion binding cell ion transport calcium ion transport cellular calcium ion homeostasis calcium-release channel activity membrane integral component of membrane release of sequestered calcium ion into cytosol transmembrane transport calcium ion transmembrane transport uc291nnu.1 uc291nnu.2 
ENSMUST00000214375.2 Or11q2 ENSMUST00000214375.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AHM8) A2AHM8 A2AHM8_MOUSE ENSMUST00000214375.1 Olfr1320 Or11q2 uc292obo.1 uc292obo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292obo.1 uc292obo.2 
ENSMUST00000214376.2 Or12d12 ENSMUST00000214376.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q920Z0) ENSMUST00000214376.1 Olfr101 Or12d12 Q920Z0 Q920Z0_MOUSE uc289kyx.1 uc289kyx.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kyx.1 uc289kyx.2 
ENSMUST00000214377.2 Or8b1c ENSMUST00000214377.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N1X5) ENSMUST00000214377.1 L7N1X5 L7N1X5_MOUSE Olfr905 Or8b1c uc009owm.1 uc009owm.2 uc009owm.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009owm.1 uc009owm.2 uc009owm.3 
ENSMUST00000214381.3 4930434F21Rik ENSMUST00000214381.3 4930434F21Rik (from geneSymbol) AK015310 ENSMUST00000214381.1 ENSMUST00000214381.2 uc292fmx.1 uc292fmx.2 uc292fmx.3 uc292fmx.1 uc292fmx.2 uc292fmx.3 
ENSMUST00000214382.2 Or4c52 ENSMUST00000214382.2 Membrane ; Multi- pass membrane protein (from UniProt Q8VG63) ENSMUST00000214382.1 Olfr1261 Olfr1263 Or4c52 Q8VG63 Q8VG63_MOUSE uc008ksi.1 uc008ksi.2 uc008ksi.3 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008ksi.1 uc008ksi.2 uc008ksi.3 
ENSMUST00000214386.2 Or5d41 ENSMUST00000214386.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFG1) ENSMUST00000214386.1 Olfr1170 Olfr1173 Or5d41 Q8VFG1 Q8VFG1_MOUSE uc289xxq.1 uc289xxq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxq.1 uc289xxq.2 
ENSMUST00000214389.2 Gm48081 ENSMUST00000214389.2 Gm48081 (from geneSymbol) AK195602 ENSMUST00000214389.1 uc292fuk.1 uc292fuk.2 uc292fuk.1 uc292fuk.2 
ENSMUST00000214392.2 Or2w3 ENSMUST00000214392.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5NCC8) ENSMUST00000214392.1 Olfr179 Olfr322 Or2w3 Q5NCC8 Q5NCC8_MOUSE uc287ykp.1 uc287ykp.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ykp.1 uc287ykp.2 
ENSMUST00000214393.2 Gm36120 ENSMUST00000214393.2 Gm36120 (from geneSymbol) ENSMUST00000214393.1 uc292jga.1 uc292jga.2 uc292jga.1 uc292jga.2 
ENSMUST00000214403.3 1700019L13Rik ENSMUST00000214403.3 1700019L13Rik (from geneSymbol) ENSMUST00000214403.1 ENSMUST00000214403.2 uc292mef.1 uc292mef.2 uc292mef.3 uc292mef.1 uc292mef.2 uc292mef.3 
ENSMUST00000214404.2 Or4x6 ENSMUST00000214404.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEZ2) ENSMUST00000214404.1 Olfr1269 Or4x6 Q8VEZ2 Q8VEZ2_MOUSE uc289yev.1 uc289yev.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yev.1 uc289yev.2 
ENSMUST00000214406.2 Or10h1 ENSMUST00000214406.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0PK55) A0PK55 A0PK55_MOUSE E9Q3X1 E9Q443 ENSMUST00000214406.1 Olfr239 Olfr55 Or10h1 uc289jtw.1 uc289jtw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289jtw.1 uc289jtw.2 
ENSMUST00000214407.2 Gm48114 ENSMUST00000214407.2 Gm48114 (from geneSymbol) ENSMUST00000214407.1 uc292geb.1 uc292geb.2 uc292geb.1 uc292geb.2 
ENSMUST00000214410.2 Or8g17 ENSMUST00000214410.2 Odorant receptor. (from UniProt Q60884) A3KMK0 ENSMUST00000214410.1 Mor171-10 O8G17_MOUSE Olfr146 Olfr7 Or8g17 Q60884 Q9EQ89 uc009oxn.1 uc009oxn.2 uc009oxn.3 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oxn.1 uc009oxn.2 uc009oxn.3 
ENSMUST00000214411.3 Or5t16 ENSMUST00000214411.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR59) ENSMUST00000214411.1 ENSMUST00000214411.2 Olfr1101 Or5t16 Q7TR59 Q7TR59_MOUSE uc289xtl.1 uc289xtl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. dopamine neurotransmitter receptor activity, coupled via Gi/Go synaptic transmission, dopaminergic G-protein coupled receptor activity adrenergic receptor activity olfactory receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway sensory perception of smell response to toxic substance regulation of dopamine secretion membrane integral component of membrane synaptic vesicle membrane dopamine binding response to drug regulation of potassium ion transport behavioral response to cocaine behavioral response to ethanol response to stimulus detection of chemical stimulus involved in sensory perception of smell negative regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway negative regulation of synaptic transmission, glutamatergic phospholipase C-activating dopamine receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway negative regulation of voltage-gated calcium channel activity uc289xtl.1 uc289xtl.2 
ENSMUST00000214412.2 Gm47126 ENSMUST00000214412.2 Gm47126 (from geneSymbol) ENSMUST00000214412.1 uc292mlx.1 uc292mlx.2 uc292mlx.1 uc292mlx.2 
ENSMUST00000214413.2 Gm17021 ENSMUST00000214413.2 Gm17021 (from geneSymbol) AK162485 ENSMUST00000214413.1 uc292mri.1 uc292mri.2 uc292mri.1 uc292mri.2 
ENSMUST00000214415.2 Gm48387 ENSMUST00000214415.2 Gm48387 (from geneSymbol) ENSMUST00000214415.1 uc292jdr.1 uc292jdr.2 uc292jdr.1 uc292jdr.2 
ENSMUST00000214416.2 Or2ah1 ENSMUST00000214416.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2ASV3) A2ASV3 A2ASV3_MOUSE ENSMUST00000214416.1 Olfr1018 Or2ah1 uc289xpr.1 uc289xpr.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xpr.1 uc289xpr.2 
ENSMUST00000214421.2 Gm48131 ENSMUST00000214421.2 Gm48131 (from geneSymbol) ENSMUST00000214421.1 uc287rbi.1 uc287rbi.2 uc287rbi.1 uc287rbi.2 
ENSMUST00000214428.3 Or4c58 ENSMUST00000214428.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGN4) ENSMUST00000214428.1 ENSMUST00000214428.2 Olfr48 Or4c58 Q8VGN4 Q8VGN4_MOUSE uc289ydr.1 uc289ydr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ydr.1 uc289ydr.2 
ENSMUST00000214429.2 Or10a2 ENSMUST00000214429.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRN0) ENSMUST00000214429.1 Olfr714 Or10a2 Q7TRN0 Q7TRN0_MOUSE uc291uec.1 uc291uec.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uec.1 uc291uec.2 
ENSMUST00000214435.2 Or2b2 ENSMUST00000214435.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQU5) ENSMUST00000214435.1 Olfr1359 Olfr1360 Or2b2 Q5SZZ5 Q7TQU5 Q7TQU5_MOUSE uc007pqz.1 uc007pqz.2 uc007pqz.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007pqz.1 uc007pqz.2 uc007pqz.3 
ENSMUST00000214438.2 Or5d35 ENSMUST00000214438.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR29) ENSMUST00000214438.1 Olfr1161 Or5d35 Q7TR29 Q7TR29_MOUSE uc289xxg.1 uc289xxg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxg.1 uc289xxg.2 
ENSMUST00000214440.2 E230034D01Rik ENSMUST00000214440.2 E230034D01Rik (from geneSymbol) AK087650 ENSMUST00000214440.1 uc292gkx.1 uc292gkx.2 uc292gkx.1 uc292gkx.2 
ENSMUST00000214446.2 Or6k6 ENSMUST00000214446.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q0M4) E9Q0M4 E9Q0M4_MOUSE ENSMUST00000214446.1 Olfr231 Or6k6 uc287oce.1 uc287oce.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287oce.1 uc287oce.2 
ENSMUST00000214451.2 C230053D17Rik ENSMUST00000214451.2 C230053D17Rik (from geneSymbol) AK082466 ENSMUST00000214451.1 uc292mhr.1 uc292mhr.2 uc292mhr.1 uc292mhr.2 
ENSMUST00000214454.2 Tyk2 ENSMUST00000214454.2 tyrosine kinase 2, transcript variant 2 (from RefSeq NM_018793.3) ENSMUST00000214454.1 NM_018793 O88431 Q3TXE3 Q52KQ2 Q8VE41 Q9R117 TYK2_MOUSE Tyk2 uc009oke.1 uc009oke.2 uc009oke.3 Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:11070174). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (By similarity). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:22859374). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (By similarity). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (By similarity). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (By similarity). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; The protein kinase 1 domain (also termed pseudokinase domain) mediates autoinhibition of the TYK2 kinase domain. Interacts (via FERM domain) with JAKMIP1. Interacts with PIK3R1; this interaction is important for cell migration. Phosphorylation by JAK1 at Tyr-1051 and Tyr-1052 induces kinase activation. Deficient mice are viable and fertile but display multiple immunological defects, most prominently high sensitivity to infections and defective tumor surveillance. Absence of TYK2 results in increased resistance against allergic, autoimmune and inflammatory disease. Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Sequence=AAD49423.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH94240.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=EDL25160.1; Type=Erroneous gene model prediction; Evidence=; nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity growth hormone receptor binding ATP binding nucleus cytoplasm cytosol cytoskeleton protein phosphorylation membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation type 1 angiotensin receptor binding intracellular signal transduction uc009oke.1 uc009oke.2 uc009oke.3 
ENSMUST00000214468.2 Gm48646 ENSMUST00000214468.2 Gm48646 (from geneSymbol) ENSMUST00000214468.1 LF197471 uc292ffm.1 uc292ffm.2 uc292ffm.1 uc292ffm.2 
ENSMUST00000214469.2 E130101E03Rik ENSMUST00000214469.2 RIKEN cDNA E130101E03 gene (from RefSeq NR_153861.1) ENSMUST00000214469.1 NR_153861 uc292fhe.1 uc292fhe.2 uc292fhe.1 uc292fhe.2 
ENSMUST00000214470.2 Plcd1 ENSMUST00000214470.2 phospholipase C, delta 1, transcript variant 1 (from RefSeq NM_001293648.1) ENSMUST00000214470.1 G5DDB7 G5DDB7_MOUSE NM_001293648 Plcd1 uc029xgo.1 uc029xgo.2 uc029xgo.3 Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33180; Evidence=; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. ; phosphatidylserine binding phosphatidylinositol phospholipase C activity phospholipase C activity calcium ion binding cytoplasm lipid metabolic process signal transduction phosphoric diester hydrolase activity lipid catabolic process hydrolase activity intracellular signal transduction phosphatidic acid binding phosphatidylinositol phosphate binding uc029xgo.1 uc029xgo.2 uc029xgo.3 
ENSMUST00000214472.2 Or4d11 ENSMUST00000214472.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFV0) ENSMUST00000214472.1 Olfr1423 Olfr1427 Or4d11 Q8VFV0 Q8VFV0_MOUSE uc289ral.1 uc289ral.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ral.1 uc289ral.2 
ENSMUST00000214477.2 Or10ak11 ENSMUST00000214477.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BRV8) A0A2I3BRV8 A0A2I3BRV8_MOUSE ENSMUST00000214477.1 Olfr1333 Or10ak11 uc290pit.1 uc290pit.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc290pit.1 uc290pit.2 
ENSMUST00000214482.2 Or11a4 ENSMUST00000214482.2 Membrane ; Multi- pass membrane protein (from UniProt Q8VFE3) ENSMUST00000214482.1 Olfr96 Or11a4 Q8VFE3 Q8VFE3_MOUSE uc289kyi.1 uc289kyi.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kyi.1 uc289kyi.2 
ENSMUST00000214485.3 Or1e31 ENSMUST00000214485.3 olfactory receptor family 1 subfamily E member 31 (from RefSeq NM_001159775.1) A0A0U1RNJ4 A0A0U1RNJ4_MOUSE ENSMUST00000214485.1 ENSMUST00000214485.2 NM_001159775 Olfr391 Olfr391-ps Or1e31 uc011xyw.1 uc011xyw.2 uc011xyw.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: DR065667.1, DR065549.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc011xyw.1 uc011xyw.2 uc011xyw.3 
ENSMUST00000214488.3 Gm3428 ENSMUST00000214488.3 Gm3428 (from geneSymbol) AK136639 ENSMUST00000214488.1 ENSMUST00000214488.2 uc292frr.1 uc292frr.2 uc292frr.3 uc292frr.1 uc292frr.2 uc292frr.3 
ENSMUST00000214490.2 Or3a1 ENSMUST00000214490.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFX7) ENSMUST00000214490.1 Olfr410 Olfr411 Or3a1 Q8VFX7 Q8VFX7_MOUSE uc288abz.1 uc288abz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288abz.1 uc288abz.2 
ENSMUST00000214497.2 Gm48855 ENSMUST00000214497.2 Gm48855 (from geneSymbol) ENSMUST00000214497.1 uc292icm.1 uc292icm.2 uc292icm.1 uc292icm.2 
ENSMUST00000214500.2 Gm29909 ENSMUST00000214500.2 Gm29909 (from geneSymbol) ENSMUST00000214500.1 uc292gke.1 uc292gke.2 uc292gke.1 uc292gke.2 
ENSMUST00000214502.2 Gm39388 ENSMUST00000214502.2 Gm39388 (from geneSymbol) ENSMUST00000214502.1 uc292jgr.1 uc292jgr.2 uc292jgr.1 uc292jgr.2 
ENSMUST00000214508.2 Or4c12b ENSMUST00000214508.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQZ1) ENSMUST00000214508.1 Olfr1255 Or4c12b Q7TQZ1 Q7TQZ1_MOUSE uc289ydn.1 uc289ydn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ydn.1 uc289ydn.2 
ENSMUST00000214529.2 Or2a5 ENSMUST00000214529.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VES9) ENSMUST00000214529.1 Olfr448 Or2a5 Q8VES9 Q8VES9_MOUSE uc291dzg.1 uc291dzg.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dzg.1 uc291dzg.2 
ENSMUST00000214538.2 Gm40518 ENSMUST00000214538.2 Gm40518 (from geneSymbol) ENSMUST00000214538.1 uc292haq.1 uc292haq.2 uc292haq.1 uc292haq.2 
ENSMUST00000214541.2 Or2y15 ENSMUST00000214541.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFA9) ENSMUST00000214541.1 Olfr1387 Or2y15 Q8VFA9 Q8VFA9_MOUSE uc287xtw.1 uc287xtw.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xtw.1 uc287xtw.2 
ENSMUST00000214553.2 Gm48334 ENSMUST00000214553.2 Gm48334 (from geneSymbol) AK020096 ENSMUST00000214553.1 uc287qiu.1 uc287qiu.2 uc287qiu.1 uc287qiu.2 
ENSMUST00000214559.2 Gm47350 ENSMUST00000214559.2 Gm47350 (from geneSymbol) ENSMUST00000214559.1 uc292idz.1 uc292idz.2 uc292idz.1 uc292idz.2 
ENSMUST00000214560.2 Gm57190 ENSMUST00000214560.2 Gm57190 (from geneSymbol) BC004794 ENSMUST00000214560.1 uc291tly.1 uc291tly.2 uc291tly.1 uc291tly.2 
ENSMUST00000214563.2 9630041A04Rik ENSMUST00000214563.2 9630041A04Rik (from geneSymbol) AK079355 ENSMUST00000214563.1 uc292kby.1 uc292kby.2 uc292kby.1 uc292kby.2 
ENSMUST00000214566.3 Or8k38 ENSMUST00000214566.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR64) ENSMUST00000214566.1 ENSMUST00000214566.2 Olfr1085 Or8k38 Q7TR64 Q7TR64_MOUSE uc289xsv.1 uc289xsv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xsv.1 uc289xsv.2 
ENSMUST00000214568.3 1700063D05Rik ENSMUST00000214568.3 1700063D05Rik (from geneSymbol) BC048584 ENSMUST00000214568.1 ENSMUST00000214568.2 uc292gfo.1 uc292gfo.2 uc292gfo.3 uc292gfo.1 uc292gfo.2 uc292gfo.3 
ENSMUST00000214573.2 Or5w15 ENSMUST00000214573.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFQ9) ENSMUST00000214573.1 Olfr1138 Or5w15 Q8VFQ9 Q8VFQ9_MOUSE uc289xwe.1 uc289xwe.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xwe.1 uc289xwe.2 
ENSMUST00000214575.3 Gm39463 ENSMUST00000214575.3 predicted gene, 39463 (from RefSeq NR_175878.1) ENSMUST00000214575.1 ENSMUST00000214575.2 NR_175878 uc292mky.1 uc292mky.2 uc292mky.3 uc292mky.1 uc292mky.2 uc292mky.3 
ENSMUST00000214577.2 Or52e19 ENSMUST00000214577.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt F8VQ26) ENSMUST00000214577.1 F8VQ26 F8VQ26_MOUSE Olfr596 Olfr603 Or52e19 uc291tpv.1 uc291tpv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tpv.1 uc291tpv.2 
ENSMUST00000214584.3 Or10p1 ENSMUST00000214584.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGJ1) ENSMUST00000214584.1 ENSMUST00000214584.2 Olfr796 Or10p1 Q8VGJ1 Q8VGJ1_MOUSE uc287vyg.1 uc287vyg.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vyg.1 uc287vyg.2 
ENSMUST00000214586.2 Gm47430 ENSMUST00000214586.2 Gm47430 (from geneSymbol) ENSMUST00000214586.1 uc292jbf.1 uc292jbf.2 uc292jbf.1 uc292jbf.2 
ENSMUST00000214587.2 Gm39377 ENSMUST00000214587.2 Gm39377 (from geneSymbol) ENSMUST00000214587.1 uc292jbw.1 uc292jbw.2 uc292jbw.1 uc292jbw.2 
ENSMUST00000214594.2 Or13a19 ENSMUST00000214594.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGL5) ENSMUST00000214594.1 Olfr525 Or13a19 Q8VGL5 Q8VGL5_MOUSE uc009khm.1 uc009khm.2 uc009khm.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009khm.1 uc009khm.2 uc009khm.3 
ENSMUST00000214599.2 Or10ab4 ENSMUST00000214599.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRV1) ENSMUST00000214599.1 Olfr479 Or10ab4 Q7TRV1 Q7TRV1_MOUSE uc291ufy.1 uc291ufy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ufy.1 uc291ufy.2 
ENSMUST00000214603.2 5830462O15Rik ENSMUST00000214603.2 5830462O15Rik (from geneSymbol) ENSMUST00000214603.1 uc292gmq.1 uc292gmq.2 uc292gmq.1 uc292gmq.2 
ENSMUST00000214605.2 Or5p1 ENSMUST00000214605.2 Potential odorant receptor. (from UniProt Q8VG06) ENSMUST00000214605.1 Mor204-11 OR5P1_MOUSE Olfr491 Or5p1 Q8VG06 uc291ugq.1 uc291ugq.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ugq.1 uc291ugq.2 
ENSMUST00000214606.2 Gm39318 ENSMUST00000214606.2 Gm39318 (from geneSymbol) ENSMUST00000214606.1 MK071708 uc292fpv.1 uc292fpv.2 uc292fpv.1 uc292fpv.2 
ENSMUST00000214616.2 Gm48277 ENSMUST00000214616.2 Gm48277 (from geneSymbol) ENSMUST00000214616.1 uc292gef.1 uc292gef.2 uc292gef.1 uc292gef.2 
ENSMUST00000214623.2 Or1e22 ENSMUST00000214623.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5SSP0) ENSMUST00000214623.1 Olfr381 Or1e22 Q5SSP0 Q5SSP0_MOUSE uc287zzo.1 uc287zzo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287zzo.1 uc287zzo.2 
ENSMUST00000214628.2 Gm47034 ENSMUST00000214628.2 Gm47034 (from geneSymbol) ENSMUST00000214628.1 uc292ekq.1 uc292ekq.2 uc292ekq.1 uc292ekq.2 
ENSMUST00000214634.2 Gm20300 ENSMUST00000214634.2 predicted gene, 20300 (from RefSeq NR_045008.1) ENSMUST00000214634.1 NR_045008 uc029qwt.1 uc029qwt.2 uc029qwt.1 uc029qwt.2 
ENSMUST00000214637.3 Or13a17 ENSMUST00000214637.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGM1) ENSMUST00000214637.1 ENSMUST00000214637.2 Olfr45 Or13a17 Q8VGM1 Q8VGM1_MOUSE uc009kia.1 uc009kia.2 uc009kia.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009kia.1 uc009kia.2 uc009kia.3 
ENSMUST00000214658.2 Gm47663 ENSMUST00000214658.2 Gm47663 (from geneSymbol) ENSMUST00000214658.1 uc292fgj.1 uc292fgj.2 uc292fgj.1 uc292fgj.2 
ENSMUST00000214661.2 Gm47000 ENSMUST00000214661.2 Gm47000 (from geneSymbol) ENSMUST00000214661.1 uc292kiu.1 uc292kiu.2 uc292kiu.1 uc292kiu.2 
ENSMUST00000214662.2 Or2ak7 ENSMUST00000214662.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRZ4) ENSMUST00000214662.1 Olfr320 Or2ak7 Q7TRZ4 Q7TRZ4_MOUSE uc007jca.1 uc007jca.2 uc007jca.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007jca.1 uc007jca.2 uc007jca.3 
ENSMUST00000214665.2 Gm47054 ENSMUST00000214665.2 Gm47054 (from geneSymbol) AK157044 ENSMUST00000214665.1 uc287qnd.1 uc287qnd.2 uc287qnd.1 uc287qnd.2 
ENSMUST00000214666.3 Gm48901 ENSMUST00000214666.3 Gm48901 (from geneSymbol) ENSMUST00000214666.1 ENSMUST00000214666.2 uc292fkb.1 uc292fkb.2 uc292fkb.3 uc292fkb.1 uc292fkb.2 uc292fkb.3 
ENSMUST00000214668.2 Or12d17 ENSMUST00000214668.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG96) ENSMUST00000214668.1 Olfr109 Or12d17 Q8VG96 Q8VG96_MOUSE uc289kzs.1 uc289kzs.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kzs.1 uc289kzs.2 
ENSMUST00000214670.2 Or5e1 ENSMUST00000214670.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFZ3) ENSMUST00000214670.1 Olfr513 Or5e1 Q8VFZ3 Q8VFZ3_MOUSE uc291uhr.1 uc291uhr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uhr.1 uc291uhr.2 
ENSMUST00000214672.2 Or6c203 ENSMUST00000214672.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGC5) ENSMUST00000214672.1 Olfr772 Or6c203 Q8VGC5 Q8VGC5_MOUSE uc287vxf.1 uc287vxf.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vxf.1 uc287vxf.2 
ENSMUST00000214676.2 Or5a1 ENSMUST00000214676.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFV2) ENSMUST00000214676.1 Olfr76 Or5a1 Q8VFV2 Q8VFV2_MOUSE uc008gtr.1 uc008gtr.2 uc008gtr.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gtr.1 uc008gtr.2 uc008gtr.3 
ENSMUST00000214677.2 Or5p56 ENSMUST00000214677.2 Potential odorant receptor. (from UniProt Q8VGI6) ENSMUST00000214677.1 Mor204-1 O5P56_MOUSE Olfr477 Or5p56 Q8VGI6 uc291ufv.1 uc291ufv.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ufv.1 uc291ufv.2 
ENSMUST00000214683.2 Gm47173 ENSMUST00000214683.2 Gm47173 (from geneSymbol) ENSMUST00000214683.1 uc292mqr.1 uc292mqr.2 uc292mqr.1 uc292mqr.2 
ENSMUST00000214685.2 Sparc ENSMUST00000214685.2 Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. (from UniProt Q5NCU5) AK014286 ENSMUST00000214685.1 Q5NCU5 Q5NCU5_MOUSE Sparc uc287yhc.1 uc287yhc.2 Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. Membrane Secreted, extracellular space, extracellular matrix, basement membrane Belongs to the SPARC family. ossification negative regulation of endothelial cell proliferation calcium ion binding collagen binding extracellular space nucleus cytoplasm heart development response to gravity cell surface response to lead ion positive regulation of endothelial cell migration nuclear matrix negative regulation of angiogenesis regulation of cell morphogenesis lung development platelet alpha granule platelet alpha granule membrane vesicle response to lipopolysaccharide response to L-ascorbic acid response to cytokine wound healing response to peptide hormone synapse response to ethanol response to cadmium ion inner ear development regulation of synapse organization response to glucocorticoid response to cAMP response to calcium ion glutamatergic synapse uc287yhc.1 uc287yhc.2 
ENSMUST00000214687.3 Or6b1 ENSMUST00000214687.3 olfactory receptor family 6 subfamily B member 1 (from RefSeq NM_001356410.1) ENSMUST00000214687.1 ENSMUST00000214687.2 NM_001356410 Olfr449 Or6b1 Q8VGW8 Q8VGW8_MOUSE uc009brz.1 uc009brz.2 uc009brz.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: DR065768.1, DR065577.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009brz.1 uc009brz.2 uc009brz.3 
ENSMUST00000214688.2 Gm29724 ENSMUST00000214688.2 Gm29724 (from geneSymbol) AK046026 ENSMUST00000214688.1 uc009orb.1 uc009orb.2 uc009orb.1 uc009orb.2 
ENSMUST00000214690.2 Or10aa1 ENSMUST00000214690.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRV9) ENSMUST00000214690.1 Olfr433 Or10aa1 Q7TRV9 Q7TRV9_MOUSE uc007dsn.1 uc007dsn.2 uc007dsn.3 uc007dsn.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007dsn.1 uc007dsn.2 uc007dsn.3 uc007dsn.4 
ENSMUST00000214691.2 Gm20149 ENSMUST00000214691.2 Gm20149 (from geneSymbol) AK037270 ENSMUST00000214691.1 uc287pxp.1 uc287pxp.2 uc287pxp.1 uc287pxp.2 
ENSMUST00000214703.2 Or4c105 ENSMUST00000214703.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF98) ENSMUST00000214703.1 Olfr1202 Or4c105 Q8VF98 Q8VF98_MOUSE uc289xzp.1 uc289xzp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xzp.1 uc289xzp.2 
ENSMUST00000214704.2 Or12d16-ps1 ENSMUST00000214704.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BQG5) A0A2I3BQG5 A0A2I3BQG5_MOUSE BC160364 ENSMUST00000214704.1 Or12d16-ps1 uc289kzi.1 uc289kzi.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kzi.1 uc289kzi.2 
ENSMUST00000214710.2 Gm39380 ENSMUST00000214710.2 Gm39380 (from geneSymbol) ENSMUST00000214710.1 uc292jds.1 uc292jds.2 uc292jds.1 uc292jds.2 
ENSMUST00000214711.2 Or51ai2 ENSMUST00000214711.2 Membrane ; Multi- pass membrane protein (from UniProt Q9EPN9) ENSMUST00000214711.1 Olfr632 Or51ai2 Q9EPN9 Q9EPN9_MOUSE uc291tsf.1 uc291tsf.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tsf.1 uc291tsf.2 
ENSMUST00000214714.3 Gm19385 ENSMUST00000214714.3 predicted gene, 19385, transcript variant 2 (from RefSeq NR_166626.1) ENSMUST00000214714.1 ENSMUST00000214714.2 NR_166626 uc292mgk.1 uc292mgk.2 uc292mgk.3 uc292mgk.1 uc292mgk.2 uc292mgk.3 
ENSMUST00000214717.2 Gm47239 ENSMUST00000214717.2 Gm47239 (from geneSymbol) AK157168 ENSMUST00000214717.1 uc292grm.1 uc292grm.2 uc292grm.1 uc292grm.2 
ENSMUST00000214721.2 Gm48372 ENSMUST00000214721.2 Gm48372 (from geneSymbol) AK083694 ENSMUST00000214721.1 uc287uga.1 uc287uga.2 uc287uga.1 uc287uga.2 
ENSMUST00000214722.2 Or5p60 ENSMUST00000214722.2 Potential odorant receptor. (from UniProt Q8VFD3) ENSMUST00000214722.1 Mor204-16 O5P60_MOUSE Olfr484 Or5p60 Q8VFD3 uc009jbz.1 uc009jbz.2 uc009jbz.3 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jbz.1 uc009jbz.2 uc009jbz.3 
ENSMUST00000214723.2 Or5w16 ENSMUST00000214723.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR39) ENSMUST00000214723.1 Olfr1140 Or5w16 Q7TR39 Q7TR39_MOUSE uc289xwg.1 uc289xwg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xwg.1 uc289xwg.2 
ENSMUST00000214725.2 Or10z1 ENSMUST00000214725.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q0Y7) E9Q0Y7 E9Q0Y7_MOUSE ENSMUST00000214725.1 Olfr419 Or10z1 uc287ocl.1 uc287ocl.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ocl.1 uc287ocl.2 
ENSMUST00000214727.3 Gm31432 ENSMUST00000214727.3 Gm31432 (from geneSymbol) ENSMUST00000214727.1 ENSMUST00000214727.2 uc292gzh.1 uc292gzh.2 uc292gzh.3 uc292gzh.1 uc292gzh.2 uc292gzh.3 
ENSMUST00000214728.2 Or2ak5 ENSMUST00000214728.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5NCD7) A0A087WP04 ENSMUST00000214728.1 Olfr316 Olfr318 Or2ak5 Q5NCD7 Q5NCD7_MOUSE uc287yky.1 uc287yky.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287yky.1 uc287yky.2 
ENSMUST00000214736.2 Gm47198 ENSMUST00000214736.2 Gm47198 (from geneSymbol) AK157591 ENSMUST00000214736.1 uc292haj.1 uc292haj.2 uc292haj.1 uc292haj.2 
ENSMUST00000214737.2 Gm47818 ENSMUST00000214737.2 Gm47818 (from geneSymbol) AK085886 ENSMUST00000214737.1 uc292iyx.1 uc292iyx.2 uc292iyx.1 uc292iyx.2 
ENSMUST00000214743.2 Or4a69 ENSMUST00000214743.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF91) ENSMUST00000214743.1 Olfr1241 Olfr1254 Or4a69 Q8VF91 Q8VF91_MOUSE uc289yco.1 uc289yco.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yco.1 uc289yco.2 
ENSMUST00000214747.2 Scaper ENSMUST00000214747.2 S phase cyclin A-associated protein in the ER, transcript variant 2 (from RefSeq NM_001357652.1) B2RXS3 B2RXS3_MOUSE ENSMUST00000214747.1 NM_001357652 Scaper uc009psn.1 uc009psn.2 uc009psn.3 molecular_function nucleic acid binding nucleus cytosol biological_process zinc ion binding metal ion binding uc009psn.1 uc009psn.2 uc009psn.3 
ENSMUST00000214751.2 Or6k4 ENSMUST00000214751.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q0Q2) E9Q0Q2 E9Q0Q2_MOUSE ENSMUST00000214751.1 Olfr424 Or6k4 uc287ocf.1 uc287ocf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ocf.1 uc287ocf.2 
ENSMUST00000214757.2 Or52n2 ENSMUST00000214757.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VH00) ENSMUST00000214757.1 Olfr666 Or52n2 Q8VH00 Q8VH00_MOUSE uc291tvh.1 uc291tvh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tvh.1 uc291tvh.2 
ENSMUST00000214759.3 Gm39456 ENSMUST00000214759.3 Gm39456 (from geneSymbol) ENSMUST00000214759.1 ENSMUST00000214759.2 uc292mfx.1 uc292mfx.2 uc292mfx.3 uc292mfx.1 uc292mfx.2 uc292mfx.3 
ENSMUST00000214760.2 Or4k35 ENSMUST00000214760.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF41) ENSMUST00000214760.1 Olfr1277 Or4k35 Q8VF41 Q8VF41_MOUSE uc008lne.1 uc008lne.2 uc008lne.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008lne.1 uc008lne.2 uc008lne.3 
ENSMUST00000214762.2 Gm48719 ENSMUST00000214762.2 Gm48719 (from geneSymbol) ENSMUST00000214762.1 uc292gtr.1 uc292gtr.2 uc292gtr.1 uc292gtr.2 
ENSMUST00000214765.3 Or52ab7 ENSMUST00000214765.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRR2) E9Q563 ENSMUST00000214765.1 ENSMUST00000214765.2 Olfr597 Olfr598 Or52ab7 Q7TRR2 Q7TRR2_MOUSE uc291tpx.1 uc291tpx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tpx.1 uc291tpx.2 
ENSMUST00000214766.2 1700092E16Rik ENSMUST00000214766.2 1700092E16Rik (from geneSymbol) AK007040 ENSMUST00000214766.1 uc287trb.1 uc287trb.2 uc287trb.1 uc287trb.2 
ENSMUST00000214769.2 Or3a1d ENSMUST00000214769.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRW8) ENSMUST00000214769.1 Olfr410 Olfr411 Or3a1d Q7TRW8 Q7TRW8_MOUSE uc288aca.1 uc288aca.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288aca.1 uc288aca.2 
ENSMUST00000214777.3 1700048O20Rik ENSMUST00000214777.3 1700048O20Rik (from geneSymbol) BC048726 ENSMUST00000214777.1 ENSMUST00000214777.2 uc009seh.1 uc009seh.2 uc009seh.3 uc009seh.4 uc009seh.5 uc009seh.1 uc009seh.2 uc009seh.3 uc009seh.4 uc009seh.5 
ENSMUST00000214783.2 Gm47963 ENSMUST00000214783.2 Gm47963 (from geneSymbol) AK089254 ENSMUST00000214783.1 uc292fvh.1 uc292fvh.2 uc292fvh.1 uc292fvh.2 
ENSMUST00000214789.2 Gm30698 ENSMUST00000214789.2 Gm30698 (from geneSymbol) ENSMUST00000214789.1 uc057awm.1 uc057awm.2 uc057awm.1 uc057awm.2 
ENSMUST00000214791.2 Gm47345 ENSMUST00000214791.2 Gm47345 (from geneSymbol) AK040294 ENSMUST00000214791.1 uc292gkz.1 uc292gkz.2 uc292gkz.1 uc292gkz.2 
ENSMUST00000214792.2 Or11g7 ENSMUST00000214792.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PV79) E9PV79 E9PV79_MOUSE E9PY57 E9Q2R0 ENSMUST00000214792.1 Olfr740 Olfr741 Or11g7 uc288tlo.1 uc288tlo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tlo.1 uc288tlo.2 
ENSMUST00000214795.2 4930517E14Rik ENSMUST00000214795.2 4930517E14Rik (from geneSymbol) ENSMUST00000214795.1 uc292fme.1 uc292fme.2 uc292fme.1 uc292fme.2 
ENSMUST00000214796.2 Or10v9 ENSMUST00000214796.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQS3) ENSMUST00000214796.1 Olfr1418 Or10v9 Q7TQS3 Q7TQS3_MOUSE uc008gte.1 uc008gte.2 uc008gte.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gte.1 uc008gte.2 uc008gte.3 
ENSMUST00000214797.3 Or4x18 ENSMUST00000214797.3 olfactory receptor family 4 subfamily X member 18 (from RefSeq NM_001270423.1) A2ATW2 A2ATW2_MOUSE D3Z4B7 ENSMUST00000214797.1 ENSMUST00000214797.2 Gm13769 NM_001270423 Olfr1506 Olfr1565 Or4x15 Or4x18 uc012byx.1 uc012byx.2 uc012byx.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: CB173711.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc012byx.1 uc012byx.2 uc012byx.3 
ENSMUST00000214801.3 Or4f47 ENSMUST00000214801.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF84) ENSMUST00000214801.1 ENSMUST00000214801.2 Olfr1317 Or4f47 Q8VF84 Q8VF84_MOUSE uc289zha.1 uc289zha.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zha.1 uc289zha.2 
ENSMUST00000214803.2 Gm48840 ENSMUST00000214803.2 Gm48840 (from geneSymbol) ENSMUST00000214803.1 LF197562 uc292gua.1 uc292gua.2 uc292gua.1 uc292gua.2 
ENSMUST00000214808.2 Gm49343 ENSMUST00000214808.2 Gm49343 (from geneSymbol) BC113767 ENSMUST00000214808.1 uc292mkp.1 uc292mkp.2 uc292mkp.1 uc292mkp.2 
ENSMUST00000214810.2 Or7g28 ENSMUST00000214810.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VET8) ENSMUST00000214810.1 Olfr846 Olfr847 Or7g28 Q8VET8 Q8VET8_MOUSE uc292etr.1 uc292etr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292etr.1 uc292etr.2 
ENSMUST00000214812.2 Gm34105 ENSMUST00000214812.2 Gm34105 (from geneSymbol) ENSMUST00000214812.1 uc292hxq.1 uc292hxq.2 uc292hxq.1 uc292hxq.2 
ENSMUST00000214815.2 Gm47092 ENSMUST00000214815.2 Gm47092 (from geneSymbol) AK035323 ENSMUST00000214815.1 uc292mhs.1 uc292mhs.2 uc292mhs.1 uc292mhs.2 
ENSMUST00000214816.2 Or4g7 ENSMUST00000214816.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQY0) ENSMUST00000214816.1 Olfr1288 Or4g7 Q7TQY0 Q7TQY0_MOUSE uc289zex.1 uc289zex.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zex.1 uc289zex.2 
ENSMUST00000214817.3 Gm35454 ENSMUST00000214817.3 Gm35454 (from geneSymbol) ENSMUST00000214817.1 ENSMUST00000214817.2 uc292mmg.1 uc292mmg.2 uc292mmg.3 uc292mmg.1 uc292mmg.2 uc292mmg.3 
ENSMUST00000214828.2 Ttc13 ENSMUST00000214828.2 tetratricopeptide repeat domain 13, transcript variant 5 (from RefSeq NM_001373943.1) A0A1L1SSC7 A0A1L1SSC7_MOUSE ENSMUST00000214828.1 NM_001373943 Ttc13 uc292eat.1 uc292eat.2 molecular_function cellular_component biological_process uc292eat.1 uc292eat.2 
ENSMUST00000214838.2 Gm47097 ENSMUST00000214838.2 Gm47097 (from geneSymbol) ENSMUST00000214838.1 uc292mik.1 uc292mik.2 uc292mik.1 uc292mik.2 
ENSMUST00000214840.2 Or2ag18 ENSMUST00000214840.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFM5) ENSMUST00000214840.1 Olfr700 Olfr705 Or2ag18 Q8VFM5 Q8VFM5_MOUSE uc291uct.1 uc291uct.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uct.1 uc291uct.2 
ENSMUST00000214843.2 Or13c7b ENSMUST00000214843.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGA9) ENSMUST00000214843.1 Olfr156 Olfr157 Or13c7b Q8VGA9 Q8VGA9_MOUSE uc290mhz.1 uc290mhz.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc290mhz.1 uc290mhz.2 
ENSMUST00000214844.2 Or4f14 ENSMUST00000214844.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2BFL7) A2BFL7 A2BFL7_MOUSE ENSMUST00000214844.1 Olfr1306 Olfr1309 Or4f14 uc289zgc.1 uc289zgc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zgc.1 uc289zgc.2 
ENSMUST00000214846.2 Or4c12 ENSMUST00000214846.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEZ1) ENSMUST00000214846.1 Olfr1259 Or4c12 Q8VEZ1 Q8VEZ1_MOUSE uc289ydw.1 uc289ydw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ydw.1 uc289ydw.2 
ENSMUST00000214853.2 Or11g1 ENSMUST00000214853.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N1X7) ENSMUST00000214853.1 L7N1X7 L7N1X7_MOUSE Olfr738 Or11g1 uc288tll.1 uc288tll.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tll.1 uc288tll.2 
ENSMUST00000214855.2 Or4x11 ENSMUST00000214855.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEZ3) ENSMUST00000214855.1 Olfr1265 Or4x11 Q8VEZ3 Q8VEZ3_MOUSE uc289yep.1 uc289yep.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yep.1 uc289yep.2 
ENSMUST00000214858.2 Or12j2 ENSMUST00000214858.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRT9) ENSMUST00000214858.1 F7AB21 Olfr527 Or12j2 Q7TRT9 Q7TRT9_MOUSE uc009khn.1 uc009khn.2 uc009khn.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009khn.1 uc009khn.2 uc009khn.3 
ENSMUST00000214865.2 Or8c11 ENSMUST00000214865.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1SRQ8) A0A1L1SRQ8 A0A1L1SRQ8_MOUSE ENSMUST00000214865.1 Olfr251 Or8c11 uc292fxx.1 uc292fxx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fxx.1 uc292fxx.2 
ENSMUST00000214876.2 Or56b2 ENSMUST00000214876.2 Membrane ; Multi- pass membrane protein (from UniProt Q99NH4) ENSMUST00000214876.1 Olfr661 Or56b2 Q99NH4 Q99NH4_MOUSE uc009iww.1 uc009iww.2 uc009iww.3 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009iww.1 uc009iww.2 uc009iww.3 
ENSMUST00000214878.2 Or6c69b ENSMUST00000214878.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFH9) ENSMUST00000214878.1 Olfr810 Or6c69b Q8VFH9 Q8VFH9_MOUSE uc287vzj.1 uc287vzj.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vzj.1 uc287vzj.2 
ENSMUST00000214883.2 Or52z13 ENSMUST00000214883.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N6B3) ENSMUST00000214883.1 K7N6B3 K7N6B3_MOUSE Olfr618 Or52z13 uc291trc.1 uc291trc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291trc.1 uc291trc.2 
ENSMUST00000214886.2 ENSMUSG00000121645 ENSMUST00000214886.2 ENSMUSG00000121645 (from geneSymbol) ENSMUST00000214886.1 uc287qmq.1 uc287qmq.2 uc287qmq.1 uc287qmq.2 
ENSMUST00000214887.2 Or10v5 ENSMUST00000214887.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGJ6) ENSMUST00000214887.1 Olfr1417 Or10v5 Q8VGJ6 Q8VGJ6_MOUSE uc289qzy.1 uc289qzy.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289qzy.1 uc289qzy.2 
ENSMUST00000214890.2 Gm47535 ENSMUST00000214890.2 Gm47535 (from geneSymbol) AK079788 ENSMUST00000214890.1 uc292emh.1 uc292emh.2 uc292emh.1 uc292emh.2 
ENSMUST00000214897.2 Or1af1 ENSMUST00000214897.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRY4) ENSMUST00000214897.1 Olfr366 Or1af1 Q7TRY4 Q7TRY4_MOUSE uc289vqs.1 uc289vqs.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vqs.1 uc289vqs.2 
ENSMUST00000214902.2 9930024M15Rik ENSMUST00000214902.2 9930024M15Rik (from geneSymbol) ENSMUST00000214902.1 uc287qua.1 uc287qua.2 uc287qua.1 uc287qua.2 
ENSMUST00000214904.2 Or8g2 ENSMUST00000214904.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFN5) ENSMUST00000214904.1 Olfr229 Olfr973 Or8g2 Q8VFN5 Q8VFN5_MOUSE uc292gcl.1 uc292gcl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gcl.1 uc292gcl.2 
ENSMUST00000214909.3 Or1j19 ENSMUST00000214909.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGK3) ENSMUST00000214909.1 ENSMUST00000214909.2 Olfr348 Or1j19 Q8VGK3 Q8VGK3_MOUSE uc289vpj.1 uc289vpj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vpj.1 uc289vpj.2 
ENSMUST00000214916.2 Or5h17 ENSMUST00000214916.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9QKE8) A0A0U1RNJ0 E9QKE8 E9QKE8_MOUSE ENSMUST00000214916.1 Olfr183 Or5h17 uc289ffr.1 uc289ffr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ffr.1 uc289ffr.2 
ENSMUST00000214917.2 Or6c33 ENSMUST00000214917.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFU5) ENSMUST00000214917.1 Olfr820 Or6c33 Q8VFU5 Q8VFU5_MOUSE uc007hra.1 uc007hra.2 uc007hra.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hra.1 uc007hra.2 uc007hra.3 
ENSMUST00000214918.2 Or4d10 ENSMUST00000214918.2 olfactory receptor family 4 subfamily D member 10 (from RefSeq NM_001011853.1) ENSMUST00000214918.1 NM_001011853 Olfr1425 Or4d10 Q7TQS1 Q7TQS1_MOUSE uc008gtn.1 uc008gtn.2 uc008gtn.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gtn.1 uc008gtn.2 uc008gtn.3 
ENSMUST00000214919.2 Or2d2 ENSMUST00000214919.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG49) D3Z4S1 ENSMUST00000214919.1 Olfr715 Or2d2 Q8VG49 Q8VG49_MOUSE uc291uei.1 uc291uei.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uei.1 uc291uei.2 
ENSMUST00000214920.3 Gm7607 ENSMUST00000214920.3 predicted gene 7607 (from RefSeq NR_152172.1) ENSMUST00000214920.1 ENSMUST00000214920.2 NR_152172 uc009oer.1 uc009oer.2 uc009oer.3 uc009oer.1 uc009oer.2 uc009oer.3 
ENSMUST00000214928.3 Or6b2 ENSMUST00000214928.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGU4) ENSMUST00000214928.1 ENSMUST00000214928.2 Olfr1415 Olfr1416 Or6b2 Q8VGU4 Q8VGU4_MOUSE uc287kly.1 uc287kly.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287kly.1 uc287kly.2 
ENSMUST00000214931.3 Gm48702 ENSMUST00000214931.3 Gm48702 (from geneSymbol) ENSMUST00000214931.1 ENSMUST00000214931.2 uc292gsp.1 uc292gsp.2 uc292gsp.3 uc292gsp.1 uc292gsp.2 uc292gsp.3 
ENSMUST00000214936.2 Or8g29-ps1 ENSMUST00000214936.2 Or8g29-ps1 (from geneSymbol) ENSMUST00000214936.1 NR_190756 uc292gat.1 uc292gat.2 uc292gat.1 uc292gat.2 
ENSMUST00000214948.2 Or2y1 ENSMUST00000214948.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQT1) ENSMUST00000214948.1 Olfr1385 Or2y1 Q7TQT1 Q7TQT1_MOUSE uc287xua.1 uc287xua.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xua.1 uc287xua.2 
ENSMUST00000214952.2 Or7a42 ENSMUST00000214952.2 Odorant receptor. (from UniProt Q60892) ENSMUST00000214952.1 O7A42_MOUSE Olfr8 Or7a42 Q60892 Q7TQV0 Q9ERY5 Q9JM18 uc287sqv.1 uc287sqv.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287sqv.1 uc287sqv.2 
ENSMUST00000214957.3 Zfp660 ENSMUST00000214957.3 Zfp660 (from geneSymbol) ENSMUST00000214957.1 ENSMUST00000214957.2 uc292mno.1 uc292mno.2 uc292mno.3 uc292mno.1 uc292mno.2 uc292mno.3 
ENSMUST00000214958.2 Or9g3 ENSMUST00000214958.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFJ7) ENSMUST00000214958.1 Olfr1012 Olfr1016 Or9g3 Q8VFJ7 Q8VFJ7_MOUSE uc289xph.1 uc289xph.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xph.1 uc289xph.2 
ENSMUST00000214959.2 Gm48232 ENSMUST00000214959.2 Gm48232 (from geneSymbol) ENSMUST00000214959.1 LF197951 uc287qid.1 uc287qid.2 uc287qid.1 uc287qid.2 
ENSMUST00000214969.2 Or12k8 ENSMUST00000214969.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF16) ENSMUST00000214969.1 Olfr361 Or12k8 Q8VF16 Q8VF16_MOUSE uc289vqi.1 uc289vqi.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vqi.1 uc289vqi.2 
ENSMUST00000214976.3 Or9a2 ENSMUST00000214976.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q924H8) ENSMUST00000214976.1 ENSMUST00000214976.2 Olfr459 Or9a2 Orz6 Q924H8 Q924H8_MOUSE uc291dwm.1 uc291dwm.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dwm.1 uc291dwm.2 
ENSMUST00000214977.2 Or6f1 ENSMUST00000214977.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFP2) ENSMUST00000214977.1 Olfr308 Or6f1 Q8VFP2 Q8VFP2_MOUSE uc009ieu.1 uc009ieu.2 uc009ieu.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ieu.1 uc009ieu.2 uc009ieu.3 
ENSMUST00000214980.2 Or10g3 ENSMUST00000214980.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF72) ENSMUST00000214980.1 Olfr1512 Or10g3 Q8VF72 Q8VF72_MOUSE uc288tvj.1 uc288tvj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tvj.1 uc288tvj.2 
ENSMUST00000214981.3 Or8d4 ENSMUST00000214981.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGB4) ENSMUST00000214981.1 ENSMUST00000214981.2 Olfr985 Or8d4 Q8VGB4 Q8VGB4_MOUSE uc292gde.1 uc292gde.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gde.1 uc292gde.2 
ENSMUST00000214985.2 Gm10688 ENSMUST00000214985.2 Gm10688 (from geneSymbol) ENSMUST00000214985.1 uc292gkv.1 uc292gkv.2 uc292gkv.1 uc292gkv.2 
ENSMUST00000214986.2 Or52n20 ENSMUST00000214986.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGV6) ENSMUST00000214986.1 Olfr659 Or52n20 Q8VGV6 Q8VGV6_MOUSE uc291tus.1 uc291tus.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tus.1 uc291tus.2 
ENSMUST00000214999.2 Gm9869 ENSMUST00000214999.2 Gm9869 (from geneSymbol) ENSMUST00000214999.1 uc292hxe.1 uc292hxe.2 uc292hxe.1 uc292hxe.2 
ENSMUST00000215009.3 Or9a7 ENSMUST00000215009.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF30) ENSMUST00000215009.1 ENSMUST00000215009.2 Olfr461 Or9a7 Q8VF30 Q8VF30_MOUSE uc291dti.1 uc291dti.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dti.1 uc291dti.2 
ENSMUST00000215014.2 Or2y17 ENSMUST00000215014.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGW9) ENSMUST00000215014.1 Olfr1390 Or2y17 Q8VGW9 Q8VGW9_MOUSE uc287xtr.1 uc287xtr.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xtr.1 uc287xtr.2 
ENSMUST00000215016.2 Cx3cr1 ENSMUST00000215016.2 Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:9918795, PubMed:10187784). CX3CR1-CX3CL1 signaling mediates cell migratory functions (PubMed:11544273, PubMed:12871640, PubMed:16675847, PubMed:18322241). Responsible for the recruitment of natural killer (NK) cells to inflamed tissues (PubMed:11544273, PubMed:16675847). Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival (PubMed:12569158, PubMed:18971423). Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung (PubMed:21037587). Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells (PubMed:12871640). Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis (PubMed:18322241). Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation (PubMed:16732273, PubMed:21778362, PubMed:24487234). Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli (PubMed:16732273). Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development (PubMed:21778362). Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development (PubMed:24487234). Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi (PubMed:15653504, PubMed:29326275). Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria (PubMed:15653504). Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection (PubMed:29326275, PubMed:33548172). Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity). (from UniProt Q9Z0D9) AK045634 CX3C1_MOUSE Cx3cr1 ENSMUST00000215016.1 Q9Z0D9 uc292mej.1 uc292mej.2 Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:9918795, PubMed:10187784). CX3CR1-CX3CL1 signaling mediates cell migratory functions (PubMed:11544273, PubMed:12871640, PubMed:16675847, PubMed:18322241). Responsible for the recruitment of natural killer (NK) cells to inflamed tissues (PubMed:11544273, PubMed:16675847). Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival (PubMed:12569158, PubMed:18971423). Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung (PubMed:21037587). Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells (PubMed:12871640). Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis (PubMed:18322241). Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation (PubMed:16732273, PubMed:21778362, PubMed:24487234). Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli (PubMed:16732273). Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development (PubMed:21778362). Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development (PubMed:24487234). Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi (PubMed:15653504, PubMed:29326275). Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria (PubMed:15653504). Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection (PubMed:29326275, PubMed:33548172). Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity). Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1. Cell membrane ; Multi-pass membrane protein Specifically expressed in subsets of leukocytes: expressed in monocytes, subsets of T-cells and natural killer (NK) cells in the circulation, dendritic cells, as well as in microglia in the central nervous system (CNS) (PubMed:10805752, PubMed:12871640, PubMed:16732273). Expression level subdivides blood monocytes into two major functional subsets; CD14(+)CD16(-)-CX3CR1(low) inflammatory monocytes and CD14(low)CD16(+)CX3CR1(high) homeostatic monocytes (PubMed:12871640). Expressed in myeloid-derived mucosal dendritic cells, which populate the entire lamina propria of the small intestine (PubMed:15653504). This protein is not N-glycosylated which is unusual for G-protein- coupled receptors. No visible phenotype in normal conditions; mice develop normally and are fertile (PubMed:10805752). Mice lacking both Cx3cr1 and Apoe show decreased atherogenesis (PubMed:12569158). In experimental autoimmune encephalomyelitis (EAE) model mice, recruitment of natural killer (NK) cells in the inflamed central nervous system (CNS) is impaired, leading to increased EAE-related mortality, nonremitting spastic paraplegia and hemorrhagic inflammatory lesions (PubMed:16675847). Mice show an increased microglial inflammatory response and neuronal death in several models of CNS insult (PubMed:16732273). Mice display reduced airway inflammation in lung after allergen sensitization (PubMed:21037587). Mice display a transient decrease in microglia density, leading to synaptic deficits characterized by an excess of weak excitatory synapses: defects are caused by a failure to eliminate immature synaptic connections during the second and third postnatal weeks (PubMed:21778362). Deficient synaptic pruning is associated with weak synaptic transmission, decreased functional brain connectivity, deficits in social interaction and increased repetitive-behavior phenotypes (PubMed:24487234). Defects of lamina propria dendritic cells are observed, leading to impair the sampling of bacteria from the intestinal lumen and affect their ability to take up invasive pathogens (PubMed:15653504). Mice are more susceptible to severe colitis that is rescued by antifungal treatment and display changes in gut fungal communities (PubMed:29326275). Belongs to the G-protein coupled receptor 1 family. microglial cell activation positive regulation of neuroblast proliferation microglial cell activation involved in immune response negative regulation of chronic inflammatory response to non-antigenic stimulus response to ischemia cytokine receptor activity G-protein coupled receptor activity nucleus nucleoplasm plasma membrane chemotaxis immune response cell adhesion signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration memory external side of plasma membrane cell surface membrane integral component of membrane C-C chemokine receptor activity C-X3-C chemokine receptor activity negative regulation of angiogenesis cytokine-mediated signaling pathway calcium-mediated signaling chemokine binding C-C chemokine binding C-X3-C chemokine binding central nervous system maturation cerebral cortex cell migration negative regulation of cell migration negative regulation of interleukin-1 beta production neuronal cell body membrane social behavior autocrine signaling regulation of tumor necrosis factor biosynthetic process neuron projection innate immune response regulation of nitric oxide biosynthetic process positive regulation of angiogenesis macrophage chemotaxis perinuclear region of cytoplasm positive regulation of neurogenesis modulation of synaptic transmission leukocyte tethering or rolling positive regulation of NF-kappaB transcription factor activity positive regulation of protein kinase B signaling synapse maturation cell chemotaxis chemokine-mediated signaling pathway cellular response to lipopolysaccharide cellular response to transforming growth factor beta stimulus dendritic tree negative regulation of long-term synaptic potentiation positive regulation of I-kappaB phosphorylation negative regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand uc292mej.1 uc292mej.2 
ENSMUST00000215017.2 Or9m1 ENSMUST00000215017.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7MU57) ENSMUST00000215017.1 L7MU57 L7MU57_MOUSE Olfr1154 Or9m1 uc289xwz.1 uc289xwz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xwz.1 uc289xwz.2 
ENSMUST00000215028.2 Gm48271 ENSMUST00000215028.2 Gm48271 (from geneSymbol) DQ559569 ENSMUST00000215028.1 uc287rbm.1 uc287rbm.2 uc287rbm.1 uc287rbm.2 
ENSMUST00000215032.2 Or5k15 ENSMUST00000215032.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q9T3) E9Q9T3 E9Q9T3_MOUSE ENSMUST00000215032.1 Olfr178 Or5k15 uc289ffi.1 uc289ffi.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ffi.1 uc289ffi.2 
ENSMUST00000215042.2 Or52ad1 ENSMUST00000215042.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PUN7) E9PUN7 E9PUN7_MOUSE ENSMUST00000215042.1 Olfr600 Or52ad1 uc009ito.1 uc009ito.2 uc009ito.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ito.1 uc009ito.2 uc009ito.3 
ENSMUST00000215045.2 Or4f15 ENSMUST00000215045.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQW9) ENSMUST00000215045.1 Olfr1309 Or4f15 Q7TQW9 Q7TQW9_MOUSE uc289zgi.1 uc289zgi.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zgi.1 uc289zgi.2 
ENSMUST00000215049.2 Or8g23 ENSMUST00000215049.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EQB4) ENSMUST00000215049.1 Olfr937 Or8g23 Q9EQB4 Q9EQB4_MOUSE uc292gab.1 uc292gab.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gab.1 uc292gab.2 
ENSMUST00000215054.2 Or4c113 ENSMUST00000215054.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7MU54) ENSMUST00000215054.1 L7MU54 L7MU54_MOUSE Olfr1218 Or4c113 uc289yao.1 uc289yao.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yao.1 uc289yao.2 
ENSMUST00000215057.2 Gm47785 ENSMUST00000215057.2 Gm47785 (from geneSymbol) ENSMUST00000215057.1 uc292for.1 uc292for.2 uc292for.1 uc292for.2 
ENSMUST00000215070.2 Gm11149 ENSMUST00000215070.2 Gm11149 (from geneSymbol) AK036529 ENSMUST00000215070.1 uc292hcg.1 uc292hcg.2 uc292hcg.1 uc292hcg.2 
ENSMUST00000215071.2 Or2ak4 ENSMUST00000215071.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A0N4SVP2) A0A0N4SVP2 A0A0N4SVP2_MOUSE ENSMUST00000215071.1 Olfr316 Or2ak4 uc007jce.1 uc007jce.2 uc007jce.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007jce.1 uc007jce.2 uc007jce.3 
ENSMUST00000215075.2 Or10ab5 ENSMUST00000215075.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF20) ENSMUST00000215075.1 Olfr509 Or10ab5 Q8VF20 Q8VF20_MOUSE uc291uhk.1 uc291uhk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uhk.1 uc291uhk.2 
ENSMUST00000215078.3 Or2n1b ENSMUST00000215078.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG94) ENSMUST00000215078.1 ENSMUST00000215078.2 Olfr133 Or2n1b Q8VG94 Q8VG94_MOUSE uc008cnz.1 uc008cnz.2 uc008cnz.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008cnz.1 uc008cnz.2 uc008cnz.3 
ENSMUST00000215083.3 Or5g29 ENSMUST00000215083.3 Potential odorant receptor. (from UniProt Q8VF76) A2ALC8 ENSMUST00000215083.1 ENSMUST00000215083.2 Mor175-5 O5G29_MOUSE Olfr998 Or5g29 Q8VF76 uc289xot.1 uc289xot.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xot.1 uc289xot.2 
ENSMUST00000215092.2 Gm47174 ENSMUST00000215092.2 Gm47174 (from geneSymbol) ENSMUST00000215092.1 uc292hry.1 uc292hry.2 uc292hry.1 uc292hry.2 
ENSMUST00000215094.2 Gm47543 ENSMUST00000215094.2 Gm47543 (from geneSymbol) AK044673 ENSMUST00000215094.1 uc009pjn.1 uc009pjn.2 uc009pjn.1 uc009pjn.2 
ENSMUST00000215096.2 Or5b113 ENSMUST00000215096.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFW1) ENSMUST00000215096.1 Olfr1467 Or5b113 Q8VFW1 Q8VFW1_MOUSE uc289ret.1 uc289ret.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ret.1 uc289ret.2 
ENSMUST00000215097.2 Gm48335 ENSMUST00000215097.2 Gm48335 (from geneSymbol) ENSMUST00000215097.1 LF197952 uc287qit.1 uc287qit.2 uc287qit.1 uc287qit.2 
ENSMUST00000215100.2 Or1j4 ENSMUST00000215100.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFP8) ENSMUST00000215100.1 Olfr350 Or1j4 Q8VFP8 Q8VFP8_MOUSE uc289vpr.1 uc289vpr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vpr.1 uc289vpr.2 
ENSMUST00000215107.2 Gm38642 ENSMUST00000215107.2 Gm38642 (from geneSymbol) ENSMUST00000215107.1 uc292mfe.1 uc292mfe.2 uc292mfe.1 uc292mfe.2 
ENSMUST00000215112.3 Or7e165 ENSMUST00000215112.3 olfactory receptor family 7 subfamily E member 165 (from RefSeq NM_011001.2) ENSMUST00000215112.1 ENSMUST00000215112.2 NM_011001 Olfr58 Or7e165 Q7TRF6 Q7TRF6_MOUSE uc009ohu.1 uc009ohu.2 uc009ohu.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB173365.1, CB173063.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ohu.1 uc009ohu.2 uc009ohu.3 
ENSMUST00000215117.3 Or13p3 ENSMUST00000215117.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQV4) ENSMUST00000215117.1 ENSMUST00000215117.2 Olfr1341 Or13p3 Q7TQV4 Q7TQV4_MOUSE uc290pik.1 uc290pik.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc290pik.1 uc290pik.2 
ENSMUST00000215122.2 Or8b46 ENSMUST00000215122.2 olfactory receptor family 8 subfamily B member 46 (from RefSeq NM_146811.2) ENSMUST00000215122.1 NM_146811 Olfr910 Or8b46 Q8VG76 Q8VG76_MOUSE uc009owr.1 uc009owr.2 uc009owr.3 uc009owr.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB173763.1, CB173250.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009owr.1 uc009owr.2 uc009owr.3 uc009owr.4 
ENSMUST00000215128.2 Or8b12b ENSMUST00000215128.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRE5) ENSMUST00000215128.1 Olfr875 Or8b12b Q7TRE5 Q7TRE5_MOUSE uc292fwj.1 uc292fwj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fwj.1 uc292fwj.2 
ENSMUST00000215131.2 E030022I16Rik ENSMUST00000215131.2 E030022I16Rik (from geneSymbol) ENSMUST00000215131.1 LF197555 uc009pea.1 uc009pea.2 uc009pea.3 uc009pea.1 uc009pea.2 uc009pea.3 
ENSMUST00000215134.2 Or5b95 ENSMUST00000215134.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFW8) BC065104 ENSMUST00000215134.1 Olfr1443 Or5b95 Q8VFW8 Q8VFW8_MOUSE uc289rct.1 uc289rct.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rct.1 uc289rct.2 
ENSMUST00000215135.2 Gm48189 ENSMUST00000215135.2 Gm48189 (from geneSymbol) ENSMUST00000215135.1 uc287pxs.1 uc287pxs.2 uc287pxs.1 uc287pxs.2 
ENSMUST00000215137.2 Or1n1 ENSMUST00000215137.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGK1) ENSMUST00000215137.1 Olfr351 Or1n1 Q8VGK1 Q8VGK1_MOUSE uc289vpt.1 uc289vpt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vpt.1 uc289vpt.2 
ENSMUST00000215138.3 Or8u8 ENSMUST00000215138.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFL0) ENSMUST00000215138.1 ENSMUST00000215138.2 Olfr52 Or8u8 Q8VFL0 Q8VFL0_MOUSE uc289xrc.1 uc289xrc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xrc.1 uc289xrc.2 
ENSMUST00000215139.2 Olfr908 ENSMUST00000215139.2 olfactory receptor 908, transcript variant 1, noncoding (from RefSeq NR_160700.1) ENSMUST00000215139.1 NR_160700 uc292fyj.1 uc292fyj.2 This olfactory receptor gene represents a polymorphic pseudogene, with both coding and noncoding alleles of this gene found in different mouse strains. The reference genome sequence encodes the noncoding allele. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jan 2019]. uc292fyj.1 uc292fyj.2 
ENSMUST00000215147.2 Or10g3b ENSMUST00000215147.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N457) ENSMUST00000215147.1 L7N457 L7N457_MOUSE Olfr1513 Or10g3b uc288tvh.1 uc288tvh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tvh.1 uc288tvh.2 
ENSMUST00000215148.2 Gm47596 ENSMUST00000215148.2 Gm47596 (from geneSymbol) AK089280 ENSMUST00000215148.1 uc292guk.1 uc292guk.2 uc292guk.1 uc292guk.2 
ENSMUST00000215150.2 Or4d2 ENSMUST00000215150.2 Membrane ; Multi- pass membrane protein (from UniProt Q5SW49) ENSMUST00000215150.1 Olfr462 Olfr463 Or4d2 Q5SW49 Q5SW49_MOUSE uc288bfy.1 uc288bfy.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288bfy.1 uc288bfy.2 
ENSMUST00000215153.3 Or4b1d ENSMUST00000215153.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQZ0) E9Q9R1 ENSMUST00000215153.1 ENSMUST00000215153.2 Olfr32 Or4b1d Q7TQZ0 Q7TQZ0_MOUSE uc289yex.1 uc289yex.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yex.1 uc289yex.2 
ENSMUST00000215159.3 Or5p59 ENSMUST00000215159.3 Potential odorant receptor. (from UniProt Q8VG05) ENSMUST00000215159.1 ENSMUST00000215159.2 Mor204-12 O5P59_MOUSE Olfr483 Or5p59 Q8VG05 uc009jby.1 uc009jby.2 uc009jby.3 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jby.1 uc009jby.2 uc009jby.3 
ENSMUST00000215160.2 Or5b105 ENSMUST00000215160.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1SSD5) A0A1L1SSD5 A0A1L1SSD5_MOUSE ENSMUST00000215160.1 Olfr1458 Or5b105 uc289reg.1 uc289reg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289reg.1 uc289reg.2 
ENSMUST00000215163.3 Or12e8 ENSMUST00000215163.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGT7) A0A1L1SSH7 ENSMUST00000215163.1 ENSMUST00000215163.2 Olfr1120 Or12e8 Q8VGT7 Q8VGT7_MOUSE uc008knu.1 uc008knu.2 uc008knu.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008knu.1 uc008knu.2 uc008knu.3 
ENSMUST00000215164.3 Or8g52 ENSMUST00000215164.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRA7) ENSMUST00000215164.1 ENSMUST00000215164.2 Olfr965 Or8g52 Q7TRA7 Q7TRA7_MOUSE uc292gby.1 uc292gby.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gby.1 uc292gby.2 
ENSMUST00000215166.2 Gm48093 ENSMUST00000215166.2 Gm48093 (from geneSymbol) ENSMUST00000215166.1 uc287qjr.1 uc287qjr.2 uc287qjr.1 uc287qjr.2 
ENSMUST00000215168.2 Or2b4 ENSMUST00000215168.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGW6) ENSMUST00000215168.1 Olfr124 Or2b4 Q8VGW6 Q8VGW6_MOUSE uc289lau.1 uc289lau.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lau.1 uc289lau.2 
ENSMUST00000215171.2 Or8u9 ENSMUST00000215171.2 Potential odorant receptor. (from UniProt Q8VGR9) ENSMUST00000215171.1 Mor185-4 OR8U9_MOUSE Olfr1044 Or8u9 Q8VGR9 uc289xqz.1 uc289xqz.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xqz.1 uc289xqz.2 
ENSMUST00000215173.2 Or5p64 ENSMUST00000215173.2 Potential odorant receptor. (from UniProt Q8VG02) ENSMUST00000215173.1 Mor204-15 O5P64_MOUSE Olfr488 Or5p64 Q8VG02 uc291ugl.1 uc291ugl.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ugl.1 uc291ugl.2 
ENSMUST00000215184.4 Gm39302 ENSMUST00000215184.4 Gm39302 (from geneSymbol) AK041135 ENSMUST00000215184.1 ENSMUST00000215184.2 ENSMUST00000215184.3 uc292fah.1 uc292fah.2 uc292fah.3 uc292fah.4 uc292fah.1 uc292fah.2 uc292fah.3 uc292fah.4 
ENSMUST00000215185.2 Or4a80 ENSMUST00000215185.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AUA2) A2AUA2 A2AUA2_MOUSE ENSMUST00000215185.1 Olfr1253 Or4a80 uc289ydk.1 uc289ydk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ydk.1 uc289ydk.2 
ENSMUST00000215190.2 Gm32017 ENSMUST00000215190.2 Gm32017 (from geneSymbol) AK137328 ENSMUST00000215190.1 uc292imw.1 uc292imw.2 uc292imw.1 uc292imw.2 
ENSMUST00000215191.2 Or8b1d ENSMUST00000215191.2 olfactory receptor family 8 subfamily B member 1D, transcript variant 1, non-coding (from RefSeq NR_160723.1) ENSMUST00000215191.1 NR_160723 uc292fym.1 uc292fym.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene appears to represent a strain-specific polymorphic pseudogene in mouse, where some strains, including the C57BL/6 reference genome strain, have a non-functional allele, while other strains have a protein-coding allele. [provided by RefSeq, Jan 2019]. uc292fym.1 uc292fym.2 
ENSMUST00000215192.2 Or10d1b ENSMUST00000215192.2 Odorant receptor. (from UniProt Q60888) 10D1B_MOUSE B9EJ08 ENSMUST00000215192.1 Mor224-8 Olfr149 Olfr7 Or10d1b Q60888 Q7TRA8 Q8VEP7 uc009oyk.1 uc009oyk.2 uc009oyk.3 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oyk.1 uc009oyk.2 uc009oyk.3 
ENSMUST00000215194.2 Or10d1 ENSMUST00000215194.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EQ86) ENSMUST00000215194.1 Olfr959 Or10d1 Q9EQ86 Q9EQ86_MOUSE uc292gbj.1 uc292gbj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gbj.1 uc292gbj.2 
ENSMUST00000215200.2 ENSMUSG00000121631 ENSMUST00000215200.2 ENSMUSG00000121631 (from geneSymbol) AK136056 ENSMUST00000215200.1 uc287qia.1 uc287qia.2 uc287qia.1 uc287qia.2 
ENSMUST00000215210.2 Or4f54 ENSMUST00000215210.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF39) ENSMUST00000215210.1 Olfr1278 Or4f54 Q8VF39 Q8VF39_MOUSE uc289zeh.1 uc289zeh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zeh.1 uc289zeh.2 
ENSMUST00000215213.2 Gm47629 ENSMUST00000215213.2 Gm47629 (from geneSymbol) ENSMUST00000215213.1 uc292gio.1 uc292gio.2 uc292gio.1 uc292gio.2 
ENSMUST00000215215.2 Or5p70 ENSMUST00000215215.2 Potential odorant receptor. (from UniProt Q8VF12) ENSMUST00000215215.1 Mor204-37 O5P70_MOUSE Olfr495 Or5p70 Q8VF12 uc009jcj.1 uc009jcj.2 uc009jcj.3 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jcj.1 uc009jcj.2 uc009jcj.3 
ENSMUST00000215216.2 2610028D06Rik ENSMUST00000215216.2 2610028D06Rik (from geneSymbol) AK011582 ENSMUST00000215216.1 uc292gvz.1 uc292gvz.2 uc292gvz.1 uc292gvz.2 
ENSMUST00000215220.2 Gm48726 ENSMUST00000215220.2 Gm48726 (from geneSymbol) AK053300 ENSMUST00000215220.1 uc292erg.1 uc292erg.2 uc292erg.1 uc292erg.2 
ENSMUST00000215225.3 Or4c114 ENSMUST00000215225.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR04) ENSMUST00000215225.1 ENSMUST00000215225.2 Olfr1219 Or4c114 Q7TR04 Q7TR04_MOUSE uc289yas.1 uc289yas.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yas.1 uc289yas.2 
ENSMUST00000215226.2 Or2y16 ENSMUST00000215226.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFA3) ENSMUST00000215226.1 Olfr1388 Or2y16 Q8VFA3 Q8VFA3_MOUSE uc287xtv.1 uc287xtv.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xtv.1 uc287xtv.2 
ENSMUST00000215229.2 Or5b104 ENSMUST00000215229.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFK3) ENSMUST00000215229.1 Olfr1457 Or5b104 Q8VFK3 Q8VFK3_MOUSE uc289ree.1 uc289ree.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ree.1 uc289ree.2 
ENSMUST00000215230.2 Or12e13 ENSMUST00000215230.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR35) ENSMUST00000215230.1 Olfr1148 Or12e13 Q7TR35 Q7TR35_MOUSE uc289xwr.1 uc289xwr.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xwr.1 uc289xwr.2 
ENSMUST00000215237.2 Or51g2 ENSMUST00000215237.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VH11) ENSMUST00000215237.1 Olfr577 Or51g2 Q8VH11 Q8VH11_MOUSE uc291tor.1 uc291tor.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tor.1 uc291tor.2 
ENSMUST00000215242.2 4930448E22Rik ENSMUST00000215242.2 4930448E22Rik (from geneSymbol) AK165035 ENSMUST00000215242.1 uc292gyy.1 uc292gyy.2 uc292gyy.1 uc292gyy.2 
ENSMUST00000215254.2 Or10j5 ENSMUST00000215254.2 Olfactory receptor. Activated by the synthetic floral odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of cedarwood oil (PubMed:25791473, PubMed:28842679, PubMed:10097159). Its activation increases intracellular Ca(2+) (PubMed:25791473, PubMed:28842679, PubMed:10097159, PubMed:15522887). Acts as a key regulator of myogenesis through its actions on cell migration and adhesion by activating the Ca(2+)-dependent AKT signal transduction pathway (PubMed:19922870). Acts also as a regulator of angiogenesis (PubMed:25791473). Moreover, plays a role in the regulation of lipid accumulation in hepatocytes via the cAMP-PKA pathway (PubMed:28842679). Involved in sperm chemotaxis and motility (PubMed:15522887). (from UniProt Q62007) ENSMUST00000215254.1 Mor23 O10J5_MOUSE Olfr16 Or10j5 Q62007 uc287nzo.1 uc287nzo.2 Olfactory receptor. Activated by the synthetic floral odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of cedarwood oil (PubMed:25791473, PubMed:28842679, PubMed:10097159). Its activation increases intracellular Ca(2+) (PubMed:25791473, PubMed:28842679, PubMed:10097159, PubMed:15522887). Acts as a key regulator of myogenesis through its actions on cell migration and adhesion by activating the Ca(2+)-dependent AKT signal transduction pathway (PubMed:19922870). Acts also as a regulator of angiogenesis (PubMed:25791473). Moreover, plays a role in the regulation of lipid accumulation in hepatocytes via the cAMP-PKA pathway (PubMed:28842679). Involved in sperm chemotaxis and motility (PubMed:15522887). Cell membrane ; Multi-pass membrane protein Expressed in the olfactory epithelium as well as in the testis (PubMed:8619840). Expressed in round spermatids during stages VI-VIII of spermatogenesis (PubMed:15522887). Up-regulated during myogenesis in vitro and muscle regeneration in vivo. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287nzo.1 uc287nzo.2 
ENSMUST00000215257.2 Gm47108 ENSMUST00000215257.2 Gm47108 (from geneSymbol) AK158480 ENSMUST00000215257.1 uc292mju.1 uc292mju.2 uc292mju.1 uc292mju.2 
ENSMUST00000215263.2 Or11j4 ENSMUST00000215263.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFT6) ENSMUST00000215263.1 Olfr736 Or11j4 Q8VFT6 Q8VFT6_MOUSE uc288tlj.1 uc288tlj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tlj.1 uc288tlj.2 
ENSMUST00000215268.2 Or5d36 ENSMUST00000215268.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFR4) ENSMUST00000215268.1 Olfr1163 Or5d36 Q8VFR4 Q8VFR4_MOUSE uc289xxk.1 uc289xxk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxk.1 uc289xxk.2 
ENSMUST00000215270.2 Or1aa2 ENSMUST00000215270.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQW2) ENSMUST00000215270.1 Olfr1324 Or1aa2 Q7TQW2 Q7TQW2_MOUSE uc292ocd.1 uc292ocd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292ocd.1 uc292ocd.2 
ENSMUST00000215280.2 Or14c40 ENSMUST00000215280.2 Odorant receptor. (from UniProt Q7TS10) ENSMUST00000215280.1 Olfr293 Or14c40 Q7TS10 Q7TS10_MOUSE uc291sjo.1 uc291sjo.2 Odorant receptor. Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291sjo.1 uc291sjo.2 
ENSMUST00000215287.2 Or8b12c ENSMUST00000215287.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRE4) ENSMUST00000215287.1 Olfr876 Or8b12c Q7TRE4 Q7TRE4_MOUSE uc292fwl.1 uc292fwl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fwl.1 uc292fwl.2 
ENSMUST00000215291.2 Gm49385 ENSMUST00000215291.2 Gm49385 (from geneSymbol) A0A1L1SR13 A0A1L1SR13_MOUSE ENSMUST00000215291.1 Gm49385 uc292fyn.1 uc292fyn.2 uc292fyn.1 uc292fyn.2 
ENSMUST00000215293.2 Cxcr5 ENSMUST00000215293.2 Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. (from UniProt Q04683) AK133064 Blr1 CXCR5_MOUSE ENSMUST00000215293.1 Gpcr6 Q04683 Q6P3C2 uc009pdx.1 uc009pdx.2 uc009pdx.3 Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. Cell membrane; Multi-pass membrane protein. Mainly in spleen, in resting B-cells. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane chemotaxis immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration external side of plasma membrane membrane integral component of membrane C-C chemokine receptor activity C-X-C chemokine receptor activity calcium-mediated signaling chemokine binding C-C chemokine binding leukocyte chemotaxis positive regulation of cytokinesis B cell activation lymph node development cell chemotaxis chemokine-mediated signaling pathway uc009pdx.1 uc009pdx.2 uc009pdx.3 
ENSMUST00000215295.2 Syne1 ENSMUST00000215295.2 spectrin repeat containing, nuclear envelope 1, transcript variant 5 (from RefSeq NM_001347732.2) A0A1L1STC6 A0A1L1STC6_MOUSE ENSMUST00000215295.1 NM_001347732 Syne1 uc007egp.1 uc007egp.2 uc007egp.3 Belongs to the nesprin family. actin binding nuclear envelope membrane integral component of membrane LINC complex actin filament binding cytoskeletal anchoring at nuclear membrane uc007egp.1 uc007egp.2 uc007egp.3 
ENSMUST00000215302.3 Or6z5 ENSMUST00000215302.3 Membrane ; Multi- pass membrane protein (from UniProt Q8VGH6) A0A140LHR7 ENSMUST00000215302.1 ENSMUST00000215302.2 Olfr1346 Or6z5 Q8VGH6 Q8VGH6_MOUSE uc291lcb.1 uc291lcb.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291lcb.1 uc291lcb.2 
ENSMUST00000215303.3 Or8g55 ENSMUST00000215303.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EQA2) ENSMUST00000215303.1 ENSMUST00000215303.2 Olfr972 Or8g55 Q9EQA2 Q9EQA2_MOUSE uc292gcj.1 uc292gcj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gcj.1 uc292gcj.2 
ENSMUST00000215306.3 Or8g27 ENSMUST00000215306.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EQ91) ENSMUST00000215306.1 ENSMUST00000215306.2 Olfr944 Or8g27 Q9EQ91 Q9EQ91_MOUSE uc292gan.1 uc292gan.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gan.1 uc292gan.2 
ENSMUST00000215311.2 Atr ENSMUST00000215311.2 ataxia telangiectasia and Rad3 related (from RefSeq NM_019864.2) A0A1L1SSL9 A0A1L1SSL9_MOUSE Atr ENSMUST00000215311.1 NM_019864 uc012gyn.1 uc012gyn.2 uc012gyn.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the PI3/PI4-kinase family. ATM subfamily. DNA damage checkpoint nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleoplasm Golgi apparatus cellular response to DNA damage stimulus negative regulation of DNA replication kinase activity phosphorylation PML body transferase activity peptidyl-serine phosphorylation MutLalpha complex binding MutSalpha complex binding cellular response to UV response to drug positive regulation of DNA damage response, signal transduction by p53 class mediator protein autophosphorylation protein localization to chromosome, telomeric region cellular response to gamma radiation replicative senescence establishment of RNA localization to telomere positive regulation of telomerase catalytic core complex assembly uc012gyn.1 uc012gyn.2 uc012gyn.3 
ENSMUST00000215316.3 2210414F02Rik ENSMUST00000215316.3 2210414F02Rik (from geneSymbol) AK008923 ENSMUST00000215316.1 ENSMUST00000215316.2 uc292ilr.1 uc292ilr.2 uc292ilr.3 uc292ilr.1 uc292ilr.2 uc292ilr.3 
ENSMUST00000215317.2 Or4k15 ENSMUST00000215317.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2RTN7) A2RTN7 A2RTN7_MOUSE ENSMUST00000215317.1 Olfr727 Or4k15 uc288tkm.1 uc288tkm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tkm.1 uc288tkm.2 
ENSMUST00000215320.3 Or8s10 ENSMUST00000215320.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A1L1B4) A1L1B4 A1L1B4_MOUSE ENSMUST00000215320.1 ENSMUST00000215320.2 Olfr282 Or8s10 uc289baq.1 uc289baq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289baq.1 uc289baq.2 
ENSMUST00000215321.2 Or4f58 ENSMUST00000215321.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VET0) ENSMUST00000215321.1 Olfr1311 Or4f58 Q8VET0 Q8VET0_MOUSE uc289zgo.1 uc289zgo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zgo.1 uc289zgo.2 
ENSMUST00000215324.2 Or2z8 ENSMUST00000215324.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRY2) ENSMUST00000215324.1 Olfr372 Or2z8 Q7TRY2 Q7TRY2_MOUSE uc292aza.1 uc292aza.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292aza.1 uc292aza.2 
ENSMUST00000215327.2 Or4k5 ENSMUST00000215327.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VET4) ENSMUST00000215327.1 Olfr729 Or4k5 Q8VET4 Q8VET4_MOUSE uc288tkt.1 uc288tkt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tkt.1 uc288tkt.2 
ENSMUST00000215330.2 Gm47266 ENSMUST00000215330.2 Gm47266 (from geneSymbol) BC126941 ENSMUST00000215330.1 uc292gdl.1 uc292gdl.2 uc292gdl.1 uc292gdl.2 
ENSMUST00000215332.2 Inpp4b ENSMUST00000215332.2 inositol polyphosphate-4-phosphatase, type II, transcript variant 4 (from RefSeq NM_001297596.1) E9PVM1 E9PVM1_MOUSE ENSMUST00000215332.1 Inpp4b NM_001297596 uc009mjg.1 uc009mjg.2 uc009mjg.3 uc009mjg.4 Reaction=1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3- phosphate + phosphate; Xref=Rhea:RHEA:43388, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58401, ChEBI:CHEBI:83241; Evidence=; Signal transduction; phosphatidylinositol signaling pathway. Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity phosphatidylinositol-3-phosphate biosynthetic process uc009mjg.1 uc009mjg.2 uc009mjg.3 uc009mjg.4 
ENSMUST00000215342.2 Gm48742 ENSMUST00000215342.2 Gm48742 (from geneSymbol) ENSMUST00000215342.1 uc292ggg.1 uc292ggg.2 uc292ggg.1 uc292ggg.2 
ENSMUST00000215347.3 Or5ap2 ENSMUST00000215347.3 Odorant receptor. (from UniProt Q8VFK7) A0A1L1STE7 ENSMUST00000215347.1 ENSMUST00000215347.2 Mor201-2 O5AP2_MOUSE Olfr1020 Or5ap2 Q0VEQ7 Q8VFK7 uc289xpt.1 uc289xpt.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xpt.1 uc289xpt.2 
ENSMUST00000215359.2 Or52n2c ENSMUST00000215359.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGW3) E9Q928 ENSMUST00000215359.1 Olfr667 Olfr668 Or52n2c Q8VGW3 Q8VGW3_MOUSE uc291tvm.1 uc291tvm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tvm.1 uc291tvm.2 
ENSMUST00000215360.2 Or2y10 ENSMUST00000215360.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQT5) ENSMUST00000215360.1 Olfr1380 Or2y10 Q7TQT5 Q7TQT5_MOUSE uc007iqt.1 uc007iqt.2 uc007iqt.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007iqt.1 uc007iqt.2 uc007iqt.3 
ENSMUST00000215363.2 Gm47334 ENSMUST00000215363.2 Gm47334 (from geneSymbol) ENSMUST00000215363.1 uc292ekb.1 uc292ekb.2 uc292ekb.1 uc292ekb.2 
ENSMUST00000215365.2 Or14c41 ENSMUST00000215365.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TS08) ENSMUST00000215365.1 Olfr295 Olfr297 Or14c41 Q7TS08 Q7TS08_MOUSE uc291sjm.1 uc291sjm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291sjm.1 uc291sjm.2 
ENSMUST00000215366.2 Gm10826 ENSMUST00000215366.2 Gm10826 (from geneSymbol) ENSMUST00000215366.1 uc287pxo.1 uc287pxo.2 uc287pxo.1 uc287pxo.2 
ENSMUST00000215369.2 Or2a12 ENSMUST00000215369.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEV0) ENSMUST00000215369.1 Olfr446 Or2a12 Q8VEV0 Q8VEV0_MOUSE uc291dzj.1 uc291dzj.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dzj.1 uc291dzj.2 
ENSMUST00000215371.2 Or10ag57 ENSMUST00000215371.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGT9) ENSMUST00000215371.1 Olfr1122 Or10ag57 Q8VGT9 Q8VGT9_MOUSE uc008knw.1 uc008knw.2 uc008knw.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008knw.1 uc008knw.2 uc008knw.3 
ENSMUST00000215373.3 Or5o1 ENSMUST00000215373.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQW4) ENSMUST00000215373.1 ENSMUST00000215373.2 Olfr1321 Or5o1 Q7TQW4 Q7TQW4_MOUSE uc009tdf.1 uc009tdf.2 uc009tdf.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009tdf.1 uc009tdf.2 uc009tdf.3 
ENSMUST00000215380.3 Or7g16 ENSMUST00000215380.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFM8) ENSMUST00000215380.1 ENSMUST00000215380.2 Olfr828 Or7g16 Q8VFM8 Q8VFM8_MOUSE uc292esw.1 uc292esw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292esw.1 uc292esw.2 
ENSMUST00000215385.3 Gm47064 ENSMUST00000215385.3 Gm47064 (from geneSymbol) ENSMUST00000215385.1 ENSMUST00000215385.2 uc292mgc.1 uc292mgc.2 uc292mgc.3 uc292mgc.1 uc292mgc.2 uc292mgc.3 
ENSMUST00000215389.2 Gm10686 ENSMUST00000215389.2 Gm10686 (from geneSymbol) AK149266 ENSMUST00000215389.1 uc292gna.1 uc292gna.2 uc292gna.1 uc292gna.2 
ENSMUST00000215396.2 Csk ENSMUST00000215396.2 c-src tyrosine kinase, transcript variant 6 (from RefSeq NM_001411644.1) CSK_MOUSE ENSMUST00000215396.1 NM_001411644 P41241 Q03143 Q80WU4 Q8VCW1 uc009pvl.1 uc009pvl.2 uc009pvl.3 Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity). Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Homodimer (via SH3-domain) (By similarity). Interacts with PTPN22 (PubMed:8890164). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and inhibit Src-family kinases (PubMed:9858471, PubMed:12218089, PubMed:12612075, PubMed:16166631). Interacts with SRCIN1 (By similarity). Interacts with RHOH (By similarity). Interacts (via SH2 domain) with SCIMP; this interaction is dependent on phosphorylation of SCIMP 'Tyr-96' (PubMed:28290451). Interacts (via SH2 domain) with PRAG1 (when phosphorylated at 'Tyr- 391'); this interaction prevents translocation of CSK from the cytoplasm to the membrane leading to increased activity of CSK (By similarity). Interacts with LRRK1 (PubMed:23526378). P41241; Q3U1F9: Pag1; NbExp=9; IntAct=EBI-2553183, EBI-8468834; P41241; P42337: Pik3ca; NbExp=2; IntAct=EBI-2553183, EBI-641748; Cytoplasm Cell membrane Note=Mainly cytoplasmic, also present in lipid rafts. Ubiquitous, but most abundant in thymus and spleen, as well as in neonatal brain. The architecture of this protein is similar to that of Src- family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain. Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated (By similarity). Mice die between day 9 and day 10 of gestation with several defects including a non-functional neural tube. SRC and FYN kinases show increased activity when CSK is missing. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. nucleotide binding adaptive immune response immune system process protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding cytoplasm plasma membrane cell-cell junction protein phosphorylation brain development negative regulation of cell proliferation negative regulation of low-density lipoprotein particle clearance membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation protein phosphatase binding negative regulation of interleukin-6 production negative regulation of kinase activity protein kinase A catalytic subunit binding adherens junction organization intracellular signal transduction identical protein binding negative regulation of Golgi to plasma membrane protein transport positive regulation of MAP kinase activity membrane raft negative regulation of bone resorption protein autophosphorylation metal ion binding oligodendrocyte differentiation negative regulation of phagocytosis regulation of T cell activation regulation of Fc receptor mediated stimulatory signaling pathway proline-rich region binding negative regulation of ERK1 and ERK2 cascade cellular response to peptide hormone stimulus uc009pvl.1 uc009pvl.2 uc009pvl.3 
ENSMUST00000215398.3 Or12d14-ps1 ENSMUST00000215398.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BRX0) A0A2I3BRX0 A0A2I3BRX0_MOUSE ENSMUST00000215398.1 ENSMUST00000215398.2 Or12d14-ps1 uc289kzc.1 uc289kzc.2 uc289kzc.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kzc.1 uc289kzc.2 uc289kzc.3 
ENSMUST00000215413.2 Or56b35 ENSMUST00000215413.2 Membrane ; Multi- pass membrane protein (from UniProt Q8VG18) ENSMUST00000215413.1 Olfr689 Or56b35 Q8VG18 Q8VG18_MOUSE uc009ixu.1 uc009ixu.2 uc009ixu.3 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ixu.1 uc009ixu.2 uc009ixu.3 
ENSMUST00000215417.2 Or52s6 ENSMUST00000215417.2 Membrane ; Multi- pass membrane protein (from UniProt E9Q838) E9Q838 E9Q838_MOUSE ENSMUST00000215417.1 Olfr605 Or52s6 uc291tqi.1 uc291tqi.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tqi.1 uc291tqi.2 
ENSMUST00000215420.2 Slc37a4 ENSMUST00000215420.2 solute carrier family 37 (glucose-6-phosphate transporter), member 4, transcript variant 11 (from RefSeq NM_001378834.1) ENSMUST00000215420.1 NM_001378834 Q9D1F9 Q9D1F9_MOUSE Slc37a4 uc009pdh.1 uc009pdh.2 uc009pdh.3 uc009pdh.4 Membrane ; Multi- pass membrane protein Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. neutrophil homeostasis cytokine production myeloid progenitor cell differentiation integral component of plasma membrane glycogen metabolic process lactate metabolic process triglyceride metabolic process cellular calcium ion homeostasis response to nutrient steroid metabolic process response to glucose response to organic cyclic compound glucose-6-phosphate transmembrane transporter activity glucose-6-phosphate transport membrane integral component of membrane transmembrane transporter activity integral component of endoplasmic reticulum membrane neutrophil chemotaxis negative regulation of chemokine production post-embryonic hemopoiesis phosphate ion transmembrane transport glucose homeostasis cholesterol homeostasis positive regulation of catalytic activity intracellular membrane-bounded organelle respiratory burst transmembrane transport glucose 6-phosphate:inorganic phosphate antiporter activity uc009pdh.1 uc009pdh.2 uc009pdh.3 uc009pdh.4 
ENSMUST00000215423.2 Or51d1 ENSMUST00000215423.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q550) E9Q550 E9Q550_MOUSE ENSMUST00000215423.1 Olfr557 Or51d1 uc291tnp.1 uc291tnp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tnp.1 uc291tnp.2 
ENSMUST00000215429.3 4930444F02Rik ENSMUST00000215429.3 RIKEN cDNA 4930444F02 gene, transcript variant 2 (from RefSeq NR_038035.1) ENSMUST00000215429.1 ENSMUST00000215429.2 NR_038035 uc007emw.1 uc007emw.2 uc007emw.3 uc007emw.4 uc007emw.5 uc007emw.6 uc007emw.1 uc007emw.2 uc007emw.3 uc007emw.4 uc007emw.5 uc007emw.6 
ENSMUST00000215431.3 Gm30015 ENSMUST00000215431.3 Gm30015 (from geneSymbol) ENSMUST00000215431.1 ENSMUST00000215431.2 uc292gkf.1 uc292gkf.2 uc292gkf.3 uc292gkf.1 uc292gkf.2 uc292gkf.3 
ENSMUST00000215436.2 Or6c66b ENSMUST00000215436.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRH9) ENSMUST00000215436.1 Olfr792 Olfr798 Or6c66b Q7TRH9 Q7TRH9_MOUSE uc287vyb.1 uc287vyb.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vyb.1 uc287vyb.2 
ENSMUST00000215440.2 Wdr72 ENSMUST00000215440.2 WD repeat domain 72, transcript variant 2 (from RefSeq NM_001411342.1) A0A1L1SR77 A0A1L1SR77_MOUSE ENSMUST00000215440.1 NM_001411342 Wdr72 uc292itn.1 uc292itn.2 uc292itn.1 uc292itn.2 
ENSMUST00000215445.2 Gm47528 ENSMUST00000215445.2 Gm47528 (from geneSymbol) ENSMUST00000215445.1 uc292gye.1 uc292gye.2 uc292gye.1 uc292gye.2 
ENSMUST00000215447.2 Or4c122 ENSMUST00000215447.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR00) ENSMUST00000215447.1 Olfr1228 Or4c122 Q7TR00 Q7TR00_MOUSE uc289ybu.1 uc289ybu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ybu.1 uc289ybu.2 
ENSMUST00000215454.3 Or56b1 ENSMUST00000215454.3 Membrane ; Multi- pass membrane protein (from UniProt Q7TRP7) ENSMUST00000215454.1 ENSMUST00000215454.2 Olfr657 Or56b1 Q7TRP7 Q7TRP7_MOUSE uc291tur.1 uc291tur.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tur.1 uc291tur.2 
ENSMUST00000215457.2 Or9m1b ENSMUST00000215457.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1W5DU97) A0A1W5DU97 A0A1W5DU97_MOUSE ENSMUST00000215457.1 Olfr1160 Or9m1b uc289xxf.1 uc289xxf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxf.1 uc289xxf.2 
ENSMUST00000215461.3 Or8b3b ENSMUST00000215461.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRC2) ENSMUST00000215461.1 ENSMUST00000215461.2 Olfr918 Or8b3b Q7TRC2 Q7TRC2_MOUSE uc292fys.1 uc292fys.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fys.1 uc292fys.2 
ENSMUST00000215468.2 Or2d3c ENSMUST00000215468.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A140T8J9) A0A140T8J9 A0A140T8J9_MOUSE ENSMUST00000215468.1 Olfr709 Or2d3c uc291udn.1 uc291udn.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291udn.1 uc291udn.2 
ENSMUST00000215474.2 Siae ENSMUST00000215474.2 sialic acid acetylesterase (from RefSeq NM_011734.4) ENSMUST00000215474.1 NM_011734 P70665 Q3TNZ5 Q544V7 Q61044 Q8C902 Q8CBM6 Q8CC41 Q8CEB7 Q922L0 SIAE_MOUSE Ysg2 uc009ovf.1 uc009ovf.2 uc009ovf.3 Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid. Reaction=H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N- acetylneuraminate; Xref=Rhea:RHEA:22600, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28999, ChEBI:CHEBI:30089, ChEBI:CHEBI:35418; EC=3.1.1.53; Reaction=H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N- acetylneuraminate; Xref=Rhea:RHEA:25564, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29006, ChEBI:CHEBI:30089, ChEBI:CHEBI:35418; EC=3.1.1.53; Inhibited by diisopropyl fluorophosphate and diethyl-P-nitrophenyl phosphate. Disulfide-linked heterodimer of a small subunit and a large subunit. [Isoform 1]: Lysosome. [Isoform 2]: Cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Lse; IsoId=P70665-1; Sequence=Displayed; Name=2; Synonyms=Cse; IsoId=P70665-2; Sequence=VSP_004077; Name=3; IsoId=P70665-3; Sequence=VSP_018996, VSP_018997; Isoform 1 is widely expressed. Isoform 2 shows a more restricted distribution with highest expression in brain and ovary and lower levels in liver and thymus. The two subunits are derived from a single precursor by proteolytic cleavage. The lysosomal isoform is glycosylated. Sequence=BAC29164.1; Type=Erroneous initiation; Evidence=; sialate O-acetylesterase activity regulation of immune system process cytoplasm lysosome carbohydrate metabolic process hydrolase activity carboxylic ester hydrolase activity uc009ovf.1 uc009ovf.2 uc009ovf.3 
ENSMUST00000215476.2 Or2aj4 ENSMUST00000215476.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TS53) ENSMUST00000215476.1 Olfr169 Or2aj4 Q7TS53 Q7TS53_MOUSE uc289dhq.1 uc289dhq.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289dhq.1 uc289dhq.2 
ENSMUST00000215479.2 Or2t35 ENSMUST00000215479.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A0U1RQ01) A0A0U1RQ01 A0A0U1RQ01_MOUSE ENSMUST00000215479.1 Olfr721 Or2t35 uc288qxj.1 uc288qxj.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288qxj.1 uc288qxj.2 
ENSMUST00000215481.2 Gm49427 ENSMUST00000215481.2 Gm49427 (from geneSymbol) ENSMUST00000215481.1 uc292meh.1 uc292meh.2 uc292meh.1 uc292meh.2 
ENSMUST00000215483.2 Gm48091 ENSMUST00000215483.2 Gm48091 (from geneSymbol) AK139724 ENSMUST00000215483.1 uc292fkp.1 uc292fkp.2 uc292fkp.1 uc292fkp.2 
ENSMUST00000215484.2 Gm47544 ENSMUST00000215484.2 Gm47544 (from geneSymbol) ENSMUST00000215484.1 uc292gyk.1 uc292gyk.2 uc292gyk.1 uc292gyk.2 
ENSMUST00000215491.2 Gm48303 ENSMUST00000215491.2 Gm48303 (from geneSymbol) BC152546 ENSMUST00000215491.1 uc292ezr.1 uc292ezr.2 uc292ezr.1 uc292ezr.2 
ENSMUST00000215499.2 Prdm10 ENSMUST00000215499.2 May be involved in transcriptional regulation. (from UniProt A0A1L1SRM4) A0A1L1SRM4 A0A1L1SRM4_MOUSE BC064128 ENSMUST00000215499.1 Prdm10 uc292fmf.1 uc292fmf.2 May be involved in transcriptional regulation. nucleic acid binding metal ion binding uc292fmf.1 uc292fmf.2 
ENSMUST00000215503.2 Or6c68 ENSMUST00000215503.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEU0) ENSMUST00000215503.1 Olfr780 Or6c68 Q8VEU0 Q8VEU0_MOUSE uc007hpt.1 uc007hpt.2 uc007hpt.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hpt.1 uc007hpt.2 uc007hpt.3 
ENSMUST00000215507.2 Gm47235 ENSMUST00000215507.2 Gm47235 (from geneSymbol) AK155716 ENSMUST00000215507.1 uc292hma.1 uc292hma.2 uc292hma.1 uc292hma.2 
ENSMUST00000215508.2 Gm47501 ENSMUST00000215508.2 Gm47501 (from geneSymbol) ENSMUST00000215508.1 uc292jbq.1 uc292jbq.2 uc292jbq.1 uc292jbq.2 
ENSMUST00000215511.2 Or5ak20 ENSMUST00000215511.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRA1) ENSMUST00000215511.1 Olfr988 Or5ak20 Q7TRA1 Q7TRA1_MOUSE uc289xof.1 uc289xof.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xof.1 uc289xof.2 
ENSMUST00000215518.2 Or12d15 ENSMUST00000215518.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BRW3) A0A2I3BRW3 A0A2I3BRW3_MOUSE ENSMUST00000215518.1 Olfr105 Or12d15 uc289kzg.1 uc289kzg.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kzg.1 uc289kzg.2 
ENSMUST00000215523.2 Or10g9 ENSMUST00000215523.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VH10) ENSMUST00000215523.1 Olfr979 Or10g9 Q8VH10 Q8VH10_MOUSE uc292gct.1 uc292gct.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gct.1 uc292gct.2 
ENSMUST00000215527.2 Or6c219 ENSMUST00000215527.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG46) ENSMUST00000215527.1 Olfr818 Or6c219 Q8VG46 Q8VG46_MOUSE uc287vzx.1 uc287vzx.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vzx.1 uc287vzx.2 
ENSMUST00000215529.3 Or4p23 ENSMUST00000215529.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR12) ENSMUST00000215529.1 ENSMUST00000215529.2 Olfr1198 Or4p23 Q7TR12 Q7TR12_MOUSE uc289xzi.1 uc289xzi.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xzi.1 uc289xzi.2 
ENSMUST00000215530.3 Gm48486 ENSMUST00000215530.3 Gm48486 (from geneSymbol) ENSMUST00000215530.1 ENSMUST00000215530.2 uc287qor.1 uc287qor.2 uc287qor.3 uc287qor.1 uc287qor.2 uc287qor.3 
ENSMUST00000215538.2 Or52ac1 ENSMUST00000215538.2 Membrane ; Multi- pass membrane protein (from UniProt E9Q252) E9Q252 E9Q252_MOUSE ENSMUST00000215538.1 Olfr655 Or52ac1 uc291tuo.1 uc291tuo.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tuo.1 uc291tuo.2 
ENSMUST00000215539.2 Gm47795 ENSMUST00000215539.2 Gm47795 (from geneSymbol) ENSMUST00000215539.1 uc292iyt.1 uc292iyt.2 uc292iyt.1 uc292iyt.2 
ENSMUST00000215541.2 Or2ag12 ENSMUST00000215541.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF89) ENSMUST00000215541.1 Olfr693 Or2ag12 Q8VF89 Q8VF89_MOUSE uc291uch.1 uc291uch.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uch.1 uc291uch.2 
ENSMUST00000215546.2 Or8g31-ps1 ENSMUST00000215546.2 Or8g31-ps1 (from geneSymbol) ENSMUST00000215546.1 uc292gaw.1 uc292gaw.2 uc292gaw.1 uc292gaw.2 
ENSMUST00000215548.3 Or5g25 ENSMUST00000215548.3 Potential odorant receptor. (from UniProt Q8VFK2) A2ALD0 ENSMUST00000215548.1 ENSMUST00000215548.2 Mor175-2 O5G25_MOUSE Olfr1002 Or5g25 Q8VFK2 uc289xoy.1 uc289xoy.2 Potential odorant receptor. Cell membrane; Multi-pass membrane protein. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xoy.1 uc289xoy.2 
ENSMUST00000215550.3 Or1a1b ENSMUST00000215550.3 Membrane ; Multi- pass membrane protein (from UniProt Q7TRX1) A0A0U1RP44 ENSMUST00000215550.1 ENSMUST00000215550.2 Olfr43 Or1a1b Q7TRX1 Q7TRX1_MOUSE uc288abk.1 uc288abk.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288abk.1 uc288abk.2 
ENSMUST00000215551.2 Gm47205 ENSMUST00000215551.2 Gm47205 (from geneSymbol) ENSMUST00000215551.1 LF197554 uc292gqg.1 uc292gqg.2 uc292gqg.1 uc292gqg.2 
ENSMUST00000215553.2 Or2v2 ENSMUST00000215553.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQS8) ENSMUST00000215553.1 Olfr1396 Or2v2 Q2NLE6 Q7TQS8 Q7TQS8_MOUSE uc287xsh.1 uc287xsh.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xsh.1 uc287xsh.2 
ENSMUST00000215560.2 Gm48159 ENSMUST00000215560.2 Gm48159 (from geneSymbol) ENSMUST00000215560.1 uc287qhp.1 uc287qhp.2 uc287qhp.1 uc287qhp.2 
ENSMUST00000215565.3 Or2a51 ENSMUST00000215565.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFS3) ENSMUST00000215565.1 ENSMUST00000215565.2 Olfr435 Or2a51 Q8VFS3 Q8VFS3_MOUSE uc291dzz.1 uc291dzz.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dzz.1 uc291dzz.2 
ENSMUST00000215569.2 Or2a57 ENSMUST00000215569.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF18) ENSMUST00000215569.1 Olfr13 Olfr47 Or2a57 Q8VF18 Q8VF18_MOUSE uc009bsl.1 uc009bsl.2 uc009bsl.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009bsl.1 uc009bsl.2 uc009bsl.3 
ENSMUST00000215572.3 Or7g27 ENSMUST00000215572.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRG2) ENSMUST00000215572.1 ENSMUST00000215572.2 Olfr845 Or7g27 Q7TRG2 Q7TRG2_MOUSE uc292etp.1 uc292etp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292etp.1 uc292etp.2 
ENSMUST00000215575.3 Or52p1 ENSMUST00000215575.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRP8) ENSMUST00000215575.1 ENSMUST00000215575.2 Olfr656 Or52p1 Q2NLE5 Q7TRP8 Q7TRP8_MOUSE uc009iwr.1 uc009iwr.2 uc009iwr.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009iwr.1 uc009iwr.2 uc009iwr.3 
ENSMUST00000215587.2 Or7g35 ENSMUST00000215587.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRF8) ENSMUST00000215587.1 F6TKI1 Olfr855 Or7g35 Q7TRF8 Q7TRF8_MOUSE uc292euc.1 uc292euc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292euc.1 uc292euc.2 
ENSMUST00000215598.2 Gm48673 ENSMUST00000215598.2 Gm48673 (from geneSymbol) ENSMUST00000215598.1 LF197481 uc292fjj.1 uc292fjj.2 uc292fjj.1 uc292fjj.2 
ENSMUST00000215600.2 Or8k35 ENSMUST00000215600.2 olfactory receptor family 8 subfamily K member 35 (from RefSeq NM_207674.2) A0A1L1SUC9 A0A1L1SUC9_MOUSE ENSMUST00000215600.1 NM_207674 Olfr1082 Or8k35 uc008kmp.1 uc008kmp.2 uc008kmp.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB173611.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kmp.1 uc008kmp.2 uc008kmp.3 
ENSMUST00000215601.2 Gm48294 ENSMUST00000215601.2 Gm48294 (from geneSymbol) ENSMUST00000215601.1 uc292gem.1 uc292gem.2 uc292gem.1 uc292gem.2 
ENSMUST00000215602.2 Nlrp4g ENSMUST00000215602.2 Nlrp4g (from geneSymbol) AK136247 ENSMUST00000215602.1 uc292msh.1 uc292msh.2 uc292msh.1 uc292msh.2 
ENSMUST00000215606.2 Or51g1 ENSMUST00000215606.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VH17) ENSMUST00000215606.1 Olfr578 Or51g1 Q8VH17 Q8VH17_MOUSE uc291tos.1 uc291tos.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tos.1 uc291tos.2 
ENSMUST00000215607.3 Or8k17 ENSMUST00000215607.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR78) ENSMUST00000215607.1 ENSMUST00000215607.2 Olfr1048 Or8k17 Q7TR78 Q7TR78_MOUSE uc289xrh.1 uc289xrh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xrh.1 uc289xrh.2 
ENSMUST00000215611.2 Or10ag52 ENSMUST00000215611.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR54) ENSMUST00000215611.1 Olfr1113 Olfr1115 Or10ag52 Q7TR54 Q7TR54_MOUSE uc289xuh.1 uc289xuh.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xuh.1 uc289xuh.2 
ENSMUST00000215612.2 Or8g51 ENSMUST00000215612.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRC1) ENSMUST00000215612.1 Olfr919 Or8g51 Q7TRC1 Q7TRC1_MOUSE uc292fyw.1 uc292fyw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. dopamine neurotransmitter receptor activity, coupled via Gi/Go synaptic transmission, dopaminergic G-protein coupled receptor activity adrenergic receptor activity olfactory receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway sensory perception of smell response to toxic substance regulation of dopamine secretion membrane integral component of membrane synaptic vesicle membrane dopamine binding response to drug regulation of potassium ion transport behavioral response to cocaine behavioral response to ethanol response to stimulus detection of chemical stimulus involved in sensory perception of smell negative regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway negative regulation of synaptic transmission, glutamatergic phospholipase C-activating dopamine receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway negative regulation of voltage-gated calcium channel activity uc292fyw.1 uc292fyw.2 
ENSMUST00000215619.2 Cdkn2d ENSMUST00000215619.2 cyclin dependent kinase inhibitor 2D, transcript variant 1 (from RefSeq NM_009878.4) CDN2D_MOUSE ENSMUST00000215619.1 NM_009878 Q60773 Q60794 Q91YV3 uc009okw.1 uc009okw.2 uc009okw.3 uc009okw.4 Interacts strongly with CDK4 and CDK6 and inhibits them. Interacts with CDK6. Nucleus Cytoplasm Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. regulation of cyclin-dependent protein serine/threonine kinase activity G1/S transition of mitotic cell cycle DNA synthesis involved in DNA repair cyclin-dependent protein serine/threonine kinase inhibitor activity nucleus nucleoplasm cytoplasm cytosol cell cycle cell cycle arrest sensory perception of sound negative regulation of cell proliferation response to UV protein kinase binding negative regulation of cell growth response to retinoic acid response to vitamin D negative regulation of phosphorylation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cyclin-dependent protein serine/threonine kinase activity autophagic cell death cyclin D2-CDK4 complex negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of cell cycle G1/S phase transition uc009okw.1 uc009okw.2 uc009okw.3 uc009okw.4 
ENSMUST00000215624.2 Or5al1 ENSMUST00000215624.2 olfactory receptor family 5 subfamily AL member 1 (from RefSeq NM_001011777.2) ENSMUST00000215624.1 NM_001011777 Olfr1042 Or5al1 Q7TR81 Q7TR81_MOUSE uc289xqv.1 uc289xqv.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC150927.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xqv.1 uc289xqv.2 
ENSMUST00000215626.2 Or2aa1 ENSMUST00000215626.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF69) ENSMUST00000215626.1 Olfr223 Or2aa1 Q8VF69 Q8VF69_MOUSE uc007jek.1 uc007jek.2 uc007jek.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007jek.1 uc007jek.2 uc007jek.3 
ENSMUST00000215630.2 Gm47095 ENSMUST00000215630.2 Gm47095 (from geneSymbol) BC052519 ENSMUST00000215630.1 uc292mid.1 uc292mid.2 uc292mid.1 uc292mid.2 
ENSMUST00000215635.3 Gm47117 ENSMUST00000215635.3 Gm47117 (from geneSymbol) AK158514 ENSMUST00000215635.1 ENSMUST00000215635.2 uc292mkz.1 uc292mkz.2 uc292mkz.3 uc292mkz.1 uc292mkz.2 uc292mkz.3 
ENSMUST00000215636.2 Gm47503 ENSMUST00000215636.2 Gm47503 (from geneSymbol) AK141143 ENSMUST00000215636.1 uc287qza.1 uc287qza.2 uc287qza.1 uc287qza.2 
ENSMUST00000215643.3 4930591E09Rik ENSMUST00000215643.3 RIKEN cDNA 4930591E09 gene (from RefSeq NR_131035.1) ENSMUST00000215643.1 ENSMUST00000215643.2 NR_131035 uc007evj.1 uc007evj.2 uc007evj.3 uc007evj.4 uc007evj.5 uc007evj.1 uc007evj.2 uc007evj.3 uc007evj.4 uc007evj.5 
ENSMUST00000215647.2 Or5h23 ENSMUST00000215647.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N1Z8) ENSMUST00000215647.1 L7N1Z8 L7N1Z8_MOUSE Olfr191 Or5h23 uc289fgc.1 uc289fgc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289fgc.1 uc289fgc.2 
ENSMUST00000215649.2 Or10d4 ENSMUST00000215649.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRA9) ENSMUST00000215649.1 Olfr963 Or10d4 Q7TRA9 Q7TRA9_MOUSE uc292gbv.1 uc292gbv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gbv.1 uc292gbv.2 
ENSMUST00000215653.2 Or51k1 ENSMUST00000215653.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGY8) AK015805 ENSMUST00000215653.1 Olfr639 Or51k1 Q8VGY8 Q8VGY8_MOUSE uc009ivc.1 uc009ivc.2 uc009ivc.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ivc.1 uc009ivc.2 uc009ivc.3 
ENSMUST00000215655.3 2310003N18Rik ENSMUST00000215655.3 2310003N18Rik (from geneSymbol) AK009126 ENSMUST00000215655.1 ENSMUST00000215655.2 uc057aom.1 uc057aom.2 uc057aom.3 uc057aom.1 uc057aom.2 uc057aom.3 
ENSMUST00000215657.2 Or51a25 ENSMUST00000215657.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VH14) ENSMUST00000215657.1 Olfr559 Or51a25 Q8VH14 Q8VH14_MOUSE uc009isk.1 uc009isk.2 uc009isk.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009isk.1 uc009isk.2 uc009isk.3 
ENSMUST00000215662.2 Gm39459 ENSMUST00000215662.2 Gm39459 (from geneSymbol) ENSMUST00000215662.1 uc292mgh.1 uc292mgh.2 uc292mgh.1 uc292mgh.2 
ENSMUST00000215667.2 BC048559 ENSMUST00000215667.2 BC048559 (from geneSymbol) AK133171 ENSMUST00000215667.1 uc007eyd.1 uc007eyd.2 uc007eyd.1 uc007eyd.2 
ENSMUST00000215671.2 Or2y1e ENSMUST00000215671.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFA4) ENSMUST00000215671.1 Olfr1391 Or2y1e Q8VFA4 Q8VFA4_MOUSE uc007iqi.1 uc007iqi.2 uc007iqi.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007iqi.1 uc007iqi.2 uc007iqi.3 
ENSMUST00000215673.2 Or51ah3 ENSMUST00000215673.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGY4) ENSMUST00000215673.1 Olfr615 Or51ah3 Q8VGY4 Q8VGY4_MOUSE uc291tqw.1 uc291tqw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tqw.1 uc291tqw.2 
ENSMUST00000215679.2 Or4c124 ENSMUST00000215679.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEX7) ENSMUST00000215679.1 Olfr1232 Or4c124 Q8VEX7 Q8VEX7_MOUSE uc289yca.1 uc289yca.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yca.1 uc289yca.2 
ENSMUST00000215680.2 Gm47723 ENSMUST00000215680.2 Gm47723 (from geneSymbol) ENSMUST00000215680.1 uc292iwt.1 uc292iwt.2 uc292iwt.1 uc292iwt.2 
ENSMUST00000215682.2 Or5m3b ENSMUST00000215682.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFK5) AK035445 ENSMUST00000215682.1 Olfr1033 Or5m3b Q8VFK5 Q8VFK5_MOUSE uc012byr.1 uc012byr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc012byr.1 uc012byr.2 
ENSMUST00000215683.2 Dcun1d5 ENSMUST00000215683.2 defective in cullin neddylation 1 domain containing 5, transcript variant 2 (from RefSeq NM_029775.3) DCNL5_MOUSE Dcun1d5 ENSMUST00000215683.1 NM_029775 Q5XKI2 Q9CUS4 Q9CXV9 SCCRO5 uc009ocf.1 uc009ocf.2 uc009ocf.3 Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) (PubMed:26792857). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth (By similarity). Part of a complex that contains DCUN1D5, CUL1 and RBX1; this interaction is bridged by CUL1. Interacts (via the DCUN1 domain) with the unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5; these interactions promote the cullin neddylation and the identity of the cullin dictates the affinity of the interaction. Interacts (via DCUN1 domain) with UBE2M (N-terminally acetylated form) and probably with UBE2F (N-terminally acetylated form). May also interact with regulators or subunits of cullin-RING ligases such as RBX1, RNF7, ELOB and DDB1; these interactions are bridged by cullins. Interacts with CAND1; this interaction is bridged by cullins and strongly inhibits the neddylation of cullins. These CAND-cullin-DCNL complexes can only be neddylated in the presence of a substrate adapter. Nucleus Cytoplasm, cytoskeleton, spindle Note=Subcellular localization is independent of the interaction with cullins. Highly expressed in testis (PubMed:26906416, PubMed:26792857). Lower levels of expression in skin, thymus, spleen, lymph nodes, lung, brain, heart, skeletal muscles, kidney, liver an ovary (PubMed:26906416, PubMed:26792857). The DCUN1 domain, also known as PONY domain, mediates the interaction with different cullins. The DCUN1 domain mediates the interaction with the N-terminally acetylated NEDD8-conjugating E2s enzyme leading to the NEDD8 transfer from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes; the neddylation efficiency correlates with the DCUN1D5- cullin and DCUN1D5-E2 interaction affinities. Phosphorylation at Ser-41 is independent of cullin's interaction (PubMed:29958295). Phosphorylated in response to both TICAM1 and MYD88 dependent Toll-like receptor (TLR) pathway activation (PubMed:29958295). Phosphorylated in response to IL1B stimulation (By similarity). Sequence=BC020048; Type=Frameshift; Evidence=; ubiquitin ligase complex molecular_function cellular_component biological_process ubiquitin conjugating enzyme binding ubiquitin-like protein binding protein neddylation positive regulation of ubiquitin-protein transferase activity cullin family protein binding uc009ocf.1 uc009ocf.2 uc009ocf.3 
ENSMUST00000215688.3 4930545L08Rik ENSMUST00000215688.3 4930545L08Rik (from geneSymbol) AK019741 ENSMUST00000215688.1 ENSMUST00000215688.2 uc292lvh.1 uc292lvh.2 uc292lvh.3 uc292lvh.1 uc292lvh.2 uc292lvh.3 
ENSMUST00000215689.2 Or1e26 ENSMUST00000215689.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGT1) ENSMUST00000215689.1 Olfr385 Or1e26 Q8VGT1 Q8VGT1_MOUSE uc287zzr.1 uc287zzr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287zzr.1 uc287zzr.2 
ENSMUST00000215690.2 Or1e35 ENSMUST00000215690.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGR3) ENSMUST00000215690.1 Olfr395 Or1e35 Q8VGR3 Q8VGR3_MOUSE uc288aal.1 uc288aal.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288aal.1 uc288aal.2 
ENSMUST00000215691.2 Or2z2 ENSMUST00000215691.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGD8) ENSMUST00000215691.1 Olfr30 Or2z2 Q8VGD8 Q8VGD8_MOUSE uc287yjp.1 uc287yjp.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287yjp.1 uc287yjp.2 
ENSMUST00000215699.2 Or7g22 ENSMUST00000215699.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFJ4) ENSMUST00000215699.1 Olfr837 Or7g22 Q8VFJ4 Q8VFJ4_MOUSE uc292etg.1 uc292etg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292etg.1 uc292etg.2 
ENSMUST00000215700.2 Gm48563 ENSMUST00000215700.2 Gm48563 (from geneSymbol) ENSMUST00000215700.1 uc287pvk.1 uc287pvk.2 uc287pvk.1 uc287pvk.2 
ENSMUST00000215702.2 Gm47784 ENSMUST00000215702.2 Gm47784 (from geneSymbol) ENSMUST00000215702.1 uc292foq.1 uc292foq.2 uc292foq.1 uc292foq.2 
ENSMUST00000215704.2 Or56a3 ENSMUST00000215704.2 Membrane ; Multi- pass membrane protein (from UniProt Q8VGV0) ENSMUST00000215704.1 Olfr679 Or56a3 Q8VGV0 Q8VGV0_MOUSE uc291twi.1 uc291twi.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291twi.1 uc291twi.2 
ENSMUST00000215712.2 Or52k2 ENSMUST00000215712.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q545) E9Q545 E9Q545_MOUSE ENSMUST00000215712.1 Olfr552 Or52k2 uc291tnd.1 uc291tnd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tnd.1 uc291tnd.2 
ENSMUST00000215713.2 Or2d2b ENSMUST00000215713.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q725) E9Q725 E9Q725_MOUSE ENSMUST00000215713.1 Olfr715b Or2d2b uc291ueg.1 uc291ueg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ueg.1 uc291ueg.2 
ENSMUST00000215723.2 Or52a20 ENSMUST00000215723.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PV96) E9PV96 E9PV96_MOUSE E9PV97 ENSMUST00000215723.1 Olfr243 Or52a20 uc291trp.1 uc291trp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291trp.1 uc291trp.2 
ENSMUST00000215724.2 Gm19299 ENSMUST00000215724.2 predicted gene, 19299 (from RefSeq NR_045748.1) ENSMUST00000215724.1 NR_045748 uc009qft.1 uc009qft.2 uc009qft.1 uc009qft.2 
ENSMUST00000215726.2 Or2g7 ENSMUST00000215726.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFC1) E9Q9I8 ENSMUST00000215726.1 Olfr117 Olfr130 Or2g7 Q8VFC1 Q8VFC1_MOUSE uc289lbk.1 uc289lbk.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lbk.1 uc289lbk.2 
ENSMUST00000215728.3 Gm39460 ENSMUST00000215728.3 Gm39460 (from geneSymbol) ENSMUST00000215728.1 ENSMUST00000215728.2 uc292mgo.1 uc292mgo.2 uc292mgo.3 uc292mgo.1 uc292mgo.2 uc292mgo.3 
ENSMUST00000215730.3 Or4a77 ENSMUST00000215730.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGM3) ENSMUST00000215730.1 ENSMUST00000215730.2 Olfr1250 Or4a77 Q8VGM3 Q8VGM3_MOUSE uc289ydc.1 uc289ydc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ydc.1 uc289ydc.2 
ENSMUST00000215732.3 Or52z14 ENSMUST00000215732.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PV95) E9PV95 E9PV95_MOUSE ENSMUST00000215732.1 ENSMUST00000215732.2 Olfr619 Or52z14 uc291trd.1 uc291trd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291trd.1 uc291trd.2 
ENSMUST00000215737.2 ENSMUSG00000121444 ENSMUST00000215737.2 ENSMUSG00000121444 (from geneSymbol) ENSMUST00000215737.1 uc292mmo.1 uc292mmo.2 uc292mmo.1 uc292mmo.2 
ENSMUST00000215746.2 Acvr2b ENSMUST00000215746.2 activin receptor IIB, transcript variant 2 (from RefSeq NM_001313757.1) AVR2B_MOUSE ENSMUST00000215746.1 NM_001313757 P27040 Q3KQI1 uc009say.1 uc009say.2 uc009say.3 uc009say.4 Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin- A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity). Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA- COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Forms an activin receptor complex with activin type II receptors such as ACVR1B. Interacts with VPS39. Interacts with DYNLT1. Interacts with BMP3 (PubMed:22074949). Interacts with BMP2 (By similarity). Interacts with BMP6 (By similarity). P27040; P36896: ACVR1B; Xeno; NbExp=4; IntAct=EBI-8571194, EBI-1384128; Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=4; Comment=ActR-IIB1 and ActR-IIB2 have similar but higher affinities for activin A than ActR-II, ActR-IIB3 and ActR-IIB4.; Name=ActR-IIB1; IsoId=P27040-1; Sequence=Displayed; Name=ActR-IIB2; IsoId=P27040-2; Sequence=VSP_004952; Name=ActR-IIB3; IsoId=P27040-3; Sequence=VSP_004951; Name=ActR-IIB4; IsoId=P27040-4; Sequence=VSP_004951, VSP_004952; Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity (By similarity). Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. negative regulation of transcription from RNA polymerase II promoter nucleotide binding skeletal system development gastrulation with mouth forming second kidney development lymphangiogenesis blood vessel remodeling protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type II protein binding ATP binding cytoplasm plasma membrane integral component of plasma membrane regulation of transcription, DNA-templated protein phosphorylation signal transduction transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway determination of left/right symmetry pattern specification process mesoderm development heart development response to glucose post-embryonic development anterior/posterior pattern specification regulation of signal transduction membrane integral component of membrane kinase activity phosphorylation transferase activity growth factor binding insulin secretion lung development positive regulation of bone mineralization BMP signaling pathway pancreas development activation of protein kinase activity activin receptor signaling pathway positive regulation of activin receptor signaling pathway macromolecular complex inhibin binding type I transforming growth factor beta receptor binding organ growth odontogenesis of dentin-containing tooth receptor complex positive regulation of osteoblast differentiation SMAD binding metal ion binding activin receptor complex activin binding embryonic foregut morphogenesis skeletal system morphogenesis palate development lymphatic endothelial cell differentiation artery development venous blood vessel development retina vasculature development in camera-type eye transforming growth factor beta binding uc009say.1 uc009say.2 uc009say.3 uc009say.4 
ENSMUST00000215753.2 Gm47215 ENSMUST00000215753.2 Gm47215 (from geneSymbol) ENSMUST00000215753.1 uc292ham.1 uc292ham.2 uc292ham.1 uc292ham.2 
ENSMUST00000215760.2 Or9q1 ENSMUST00000215760.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQQ3) ENSMUST00000215760.1 Olfr1500 Or9q1 Q7TQQ3 Q7TQQ3_MOUSE uc289rhe.1 uc289rhe.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rhe.1 uc289rhe.2 
ENSMUST00000215763.2 Or8j3 ENSMUST00000215763.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR80) ENSMUST00000215763.1 Olfr1045 Or8j3 Q7TR80 Q7TR80_MOUSE uc289xrd.1 uc289xrd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xrd.1 uc289xrd.2 
ENSMUST00000215768.2 Or12j5 ENSMUST00000215768.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFE9) BC051116 ENSMUST00000215768.1 Olfr536 Or12j5 Q80XD6 Q8VFE9 Q8VFE9_MOUSE uc291wvb.1 uc291wvb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291wvb.1 uc291wvb.2 
ENSMUST00000215772.2 C230099D08Rik ENSMUST00000215772.2 C230099D08Rik (from geneSymbol) AK082738 ENSMUST00000215772.1 uc007gkn.1 uc007gkn.2 uc007gkn.1 uc007gkn.2 
ENSMUST00000215773.2 Or51s1 ENSMUST00000215773.2 Membrane ; Multi- pass membrane protein (from UniProt E9Q407) E9Q407 E9Q407_MOUSE ENSMUST00000215773.1 Olfr571 Or51s1 uc291tog.1 uc291tog.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tog.1 uc291tog.2 
ENSMUST00000215780.2 Nxpe4 ENSMUST00000215780.2 Secreted (from UniProt Q52KP5) BC094249 ENSMUST00000215780.1 Fam55d NXPE4_MOUSE Q0VGS9 Q52KP5 Q8BKY4 uc009phu.1 uc009phu.2 uc009phu.3 uc009phu.4 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q52KP5-1; Sequence=Displayed; Name=2; IsoId=Q52KP5-2; Sequence=VSP_014702; Belongs to the NXPE family. molecular_function extracellular region biological_process uc009phu.1 uc009phu.2 uc009phu.3 uc009phu.4 
ENSMUST00000215781.2 Or4c107 ENSMUST00000215781.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR08) ENSMUST00000215781.1 Olfr1212 Or4c107 Q7TR08 Q7TR08_MOUSE uc289yab.1 uc289yab.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yab.1 uc289yab.2 
ENSMUST00000215782.3 Or51h5 ENSMUST00000215782.3 Membrane ; Multi- pass membrane protein (from UniProt Q8VGZ3) ENSMUST00000215782.1 ENSMUST00000215782.2 Olfr572 Or51h5 Q8VGZ3 Q8VGZ3_MOUSE uc291toi.1 uc291toi.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291toi.1 uc291toi.2 
ENSMUST00000215793.2 Or11g27 ENSMUST00000215793.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N1Y2) ENSMUST00000215793.1 L7N1Y2 L7N1Y2_MOUSE Olfr743 Or11g27 uc288tlt.1 uc288tlt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tlt.1 uc288tlt.2 
ENSMUST00000215796.2 Or2f1b ENSMUST00000215796.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGP4) ENSMUST00000215796.1 Olfr38 Olfr453 Or2f1b Q8VGP4 Q8VGP4_MOUSE uc291dyv.1 uc291dyv.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dyv.1 uc291dyv.2 
ENSMUST00000215798.2 Gm48125 ENSMUST00000215798.2 Gm48125 (from geneSymbol) ENSMUST00000215798.1 uc287rbf.1 uc287rbf.2 uc287rbf.1 uc287rbf.2 
ENSMUST00000215804.2 Or2w1 ENSMUST00000215804.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQT8) ENSMUST00000215804.1 Olfr263 Olfr263-ps1 Olfr42 Or2w1 Q7TQT8 Q7TQT8_MOUSE uc007ppw.1 uc007ppw.2 uc007ppw.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007ppw.1 uc007ppw.2 uc007ppw.3 
ENSMUST00000215806.2 Or2p2 ENSMUST00000215806.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFG4) ENSMUST00000215806.1 Olfr1370 Or2p2 Q8VFG4 Q8VFG4_MOUSE uc288ldu.1 uc288ldu.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288ldu.1 uc288ldu.2 
ENSMUST00000215810.2 Gm47319 ENSMUST00000215810.2 Gm47319 (from geneSymbol) ENSMUST00000215810.1 uc292enb.1 uc292enb.2 uc292enb.1 uc292enb.2 
ENSMUST00000215811.2 Or10al2 ENSMUST00000215811.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRJ6) ENSMUST00000215811.1 G5E8U0 Olfr118 Olfr120 Or10al2 Q7TRJ6 Q7TRJ6_MOUSE uc289laj.1 uc289laj.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289laj.1 uc289laj.2 
ENSMUST00000215815.2 Or6b13 ENSMUST00000215815.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRU0) ENSMUST00000215815.1 Olfr524 Or6b13 Q7TRU0 Q7TRU0_MOUSE uc009khh.1 uc009khh.2 uc009khh.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009khh.1 uc009khh.2 uc009khh.3 
ENSMUST00000215816.3 Or4c117 ENSMUST00000215816.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR02) ENSMUST00000215816.1 ENSMUST00000215816.2 Olfr1222 Or4c117 Q7TR02 Q7TR02_MOUSE uc289yay.1 uc289yay.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yay.1 uc289yay.2 
ENSMUST00000215817.2 Upf1 ENSMUST00000215817.2 UPF1 RNA helicase and ATPase, transcript variant 2 (from RefSeq NM_030680.4) ENSMUST00000215817.1 NM_030680 Q3UG00 Q6GYP5 Q6PHQ5 Q8K0N4 Q99PR4 Q9EPU0 RENT1_MOUSE Rent1 Upf1 uc012gfa.1 uc012gfa.2 uc012gfa.3 RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (By similarity). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (By similarity). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (By similarity). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (By similarity). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (By similarity). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (By similarity). Plays a role in replication- dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (By similarity). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (By similarity). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (By similarity). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (PubMed:27149095). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence=; Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Associates with the SGM1C complex; is phosphorylated by the complex kinase component SGM1. Part of a complex composed of SMG1, DHX34 and UPF1; within the complex DHX34 acts as a scaffolding protein to facilitate SMG1 phosphorylation of UPF1 (By similarity). Interacts with UPF2. Interacts with UPF3A and UPF3B. Interacts with EST1A. Interacts with SLBP. Interacts (when hyperphosphorylated) with PNRC2. Interacts with AGO1 and AGO2. Interacts with GSPT2. Interacts with isoform 1 and isoform 5 of ADAR/ADAR1. Interacts with SMG7. Interacts with ZC3H12A; this interaction occurs in a mRNA translationally active- and termination-dependent manner and is essential for ZC3H12A-mediated degradation of target mRNAs. Interacts with CPSF6. Interacts with MOV10; the interaction is direct and RNA-dependent. Interacts with SHFL; the interaction increases in the presence of RNA. Interacts with UPF2 and DDX4; interactions are mediated by TDRD6 (PubMed:27149095). Interacts with DHX34 and PABPC1/PABP1; the interactions are RNA- independent (By similarity). Interacts with RBM46 (PubMed:36001654). Q9EPU0; Q7TMF2: Eri1; NbExp=2; IntAct=EBI-6876715, EBI-16026214; Cytoplasm Cytoplasm, P-body Nucleus Cytoplasm, perinuclear region Note=Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm (By similarity). Localized in the chromatoid bodies of round spermatids (PubMed:27149095). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EPU0-1; Sequence=Displayed; Name=2; IsoId=Q9EPU0-2; Sequence=VSP_025764; Localizes in male germ cells. Weakly expressed in neonatal testes and expression increases during the development of spermatocytes and spermatids, in the late meiotic and postmeiotic stages of spermatogenesis. The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family. Phosphorylated by SMG1; required for formation of mRNA surveillance complexes. Embryos are viable in pre-implantation period, show complete loss of NMD but are resorbed shortly after implantation. Belongs to the DNA2/NAM7 helicase family. nucleotide binding nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay nuclear chromosome, telomeric region chromatin P-body nuclear-transcribed mRNA catabolic process DNA binding chromatin binding RNA binding RNA helicase activity helicase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol DNA replication DNA repair regulation of translational termination zinc ion binding dosage compensation by inactivation of X chromosome hydrolase activity telomere maintenance via semi-conservative replication regulation of telomere maintenance exon-exon junction complex telomeric DNA binding supraspliceosomal complex cell cycle phase transition metal ion binding positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization histone mRNA catabolic process cellular response to lipopolysaccharide cellular response to interleukin-1 uc012gfa.1 uc012gfa.2 uc012gfa.3 
ENSMUST00000215830.2 Or8s2 ENSMUST00000215830.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGU2) ENSMUST00000215830.1 Olfr283 Or8s2 Q8VGU2 Q8VGU2_MOUSE uc007xmi.1 uc007xmi.2 uc007xmi.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007xmi.1 uc007xmi.2 uc007xmi.3 
ENSMUST00000215835.2 D030034A15Rik ENSMUST00000215835.2 D030034A15Rik (from geneSymbol) AK083501 ENSMUST00000215835.1 uc287qoo.1 uc287qoo.2 uc287qoo.1 uc287qoo.2 
ENSMUST00000215836.2 Arfgef3 ENSMUST00000215836.2 ARFGEF family member 3 (from RefSeq NM_001033258.4) Arfgef3 BIG3_MOUSE Big3 D10Bwg1379e ENSMUST00000215836.1 Kiaa1244 NM_001033258 Q3UGY8 Q80TH0 uc007emn.1 uc007emn.2 uc007emn.3 Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (PubMed:24711543). Also regulates glucagon granule production in pancreatic alpha cells (PubMed:25737957). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (By similarity). Interacts with PHB2 (By similarity). Cytoplasmic vesicle, secretory vesicle Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein Expressed in pancreatic islet (insulin granules of islet alpha and beta cells) and brain (at protein level). Viable and fertile with normal body weight gain. Mice exhibit postprandial hyperinsulinemia and hyperglycemia, and impaired glucose tolerance. Three month old animals show severe insulin resistance in liver and muscle tissue, probably due to chronic insulin exposure. guanyl-nucleotide exchange factor activity ARF guanyl-nucleotide exchange factor activity negative regulation of phosphatase activity membrane integral component of membrane actin cytoskeleton organization transport vesicle transport vesicle membrane cytoplasmic vesicle regulation of ARF protein signal transduction uc007emn.1 uc007emn.2 uc007emn.3 
ENSMUST00000215840.2 Gm47483 ENSMUST00000215840.2 Gm47483 (from geneSymbol) ENSMUST00000215840.1 uc287qhi.1 uc287qhi.2 uc287qhi.1 uc287qhi.2 
ENSMUST00000215867.2 Gm47778 ENSMUST00000215867.2 Gm47778 (from geneSymbol) ENSMUST00000215867.1 uc292foo.1 uc292foo.2 uc292foo.1 uc292foo.2 
ENSMUST00000215871.3 Or10u3 ENSMUST00000215871.3 olfactory receptor family 10 subfamily U member 3 (from RefSeq NM_146269.2) ENSMUST00000215871.1 ENSMUST00000215871.2 Gm10310 NM_146269 Olfr247 Or10u3 Q7TS26 Q7TS26_MOUSE uc057kkd.1 uc057kkd.2 uc057kkd.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc057kkd.1 uc057kkd.2 uc057kkd.3 
ENSMUST00000215873.2 Gm48727 ENSMUST00000215873.2 Gm48727 (from geneSymbol) ENSMUST00000215873.1 uc287pla.1 uc287pla.2 uc287pla.1 uc287pla.2 
ENSMUST00000215876.2 Gm48256 ENSMUST00000215876.2 Gm48256 (from geneSymbol) ENSMUST00000215876.1 uc292fhf.1 uc292fhf.2 uc292fhf.1 uc292fhf.2 
ENSMUST00000215879.2 Or1j15 ENSMUST00000215879.2 Membrane ; Multi- pass membrane protein (from UniProt Q8VFP9) ENSMUST00000215879.1 Olfr344 Or1j15 Q8VFP9 Q8VFP9_MOUSE uc289vpe.1 uc289vpe.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vpe.1 uc289vpe.2 
ENSMUST00000215882.2 Gm47179 ENSMUST00000215882.2 Gm47179 (from geneSymbol) ENSMUST00000215882.1 uc292msd.1 uc292msd.2 uc292msd.1 uc292msd.2 
ENSMUST00000215885.2 Gm35940 ENSMUST00000215885.2 Gm35940 (from geneSymbol) ENSMUST00000215885.1 uc292ghx.1 uc292ghx.2 uc292ghx.1 uc292ghx.2 
ENSMUST00000215893.2 Or5ac21 ENSMUST00000215893.2 olfactory receptor family 5 subfamily AC member 21 (from RefSeq NM_146486.2) A0A1L1SSG9 A0A1L1SSG9_MOUSE ENSMUST00000215893.1 NM_146486 Olfr203 Or5ac21 uc007zpa.1 uc007zpa.2 uc007zpa.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC128025.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007zpa.1 uc007zpa.2 uc007zpa.3 
ENSMUST00000215895.2 Gm48565 ENSMUST00000215895.2 Gm48565 (from geneSymbol) AK038159 ENSMUST00000215895.1 uc292gfa.1 uc292gfa.2 uc292gfa.1 uc292gfa.2 
ENSMUST00000215900.2 Or2n1 ENSMUST00000215900.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG95) ENSMUST00000215900.1 Olfr134 Or2n1 Q8VG95 Q8VG95_MOUSE uc289lbv.1 uc289lbv.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lbv.1 uc289lbv.2 
ENSMUST00000215903.2 Or5d16 ENSMUST00000215903.2 Membrane ; Multi- pass membrane protein (from UniProt Q8VFR3) ENSMUST00000215903.1 Olfr1155 Or5d16 Q8VFR3 Q8VFR3_MOUSE uc289xxb.1 uc289xxb.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxb.1 uc289xxb.2 
ENSMUST00000215907.2 Smco4 ENSMUST00000215907.2 single-pass membrane protein with coiled-coil domains 4, transcript variant 1 (from RefSeq NM_001359604.1) ENSMUST00000215907.1 Fn5 NM_001359604 Q8VD32 Q9JIS3 SMCO4_MOUSE uc033jiv.1 uc033jiv.2 uc033jiv.3 Membrane ; Single-pass membrane protein Belongs to the SMCO4 family. molecular_function cellular_component biological_process membrane integral component of membrane uc033jiv.1 uc033jiv.2 uc033jiv.3 
ENSMUST00000215909.2 Or10ag58 ENSMUST00000215909.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AT86) A2AT86 A2AT86_MOUSE ENSMUST00000215909.1 Olfr1124 Or10ag58 uc289xvd.1 uc289xvd.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xvd.1 uc289xvd.2 
ENSMUST00000215914.2 Gm47378 ENSMUST00000215914.2 Gm47378 (from geneSymbol) ENSMUST00000215914.1 uc287ran.1 uc287ran.2 uc287ran.1 uc287ran.2 
ENSMUST00000215915.2 Or3a4 ENSMUST00000215915.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRX3) ENSMUST00000215915.1 Olfr399 Or3a4 Q7TRX3 Q7TRX3_MOUSE uc288aay.1 uc288aay.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288aay.1 uc288aay.2 
ENSMUST00000215920.3 E230014E18Rik ENSMUST00000215920.3 E230014E18Rik (from geneSymbol) AK054042 ENSMUST00000215920.1 ENSMUST00000215920.2 uc007gkp.1 uc007gkp.2 uc007gkp.3 uc007gkp.1 uc007gkp.2 uc007gkp.3 
ENSMUST00000215922.2 Or8g37 ENSMUST00000215922.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFN3) ENSMUST00000215922.1 Olfr970 Or8g37 Q8VFN3 Q8VFN3_MOUSE uc292gcf.1 uc292gcf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gcf.1 uc292gcf.2 
ENSMUST00000215928.3 Or10g1 ENSMUST00000215928.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PZZ6) E9PZZ6 E9PZZ6_MOUSE ENSMUST00000215928.1 ENSMUST00000215928.2 Olfr1510 Or10g1 uc288tvm.1 uc288tvm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tvm.1 uc288tvm.2 
ENSMUST00000215929.2 Or4c11c ENSMUST00000215929.2 olfactory receptor family 4 subfamily C member 11C (from RefSeq NM_146896.3) A2ATJ7 A2ATJ7_MOUSE ENSMUST00000215929.1 NM_146896 Olfr1205 Or4c11c uc008kqj.1 uc008kqj.2 uc008kqj.3 uc008kqj.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: CB173441.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kqj.1 uc008kqj.2 uc008kqj.3 uc008kqj.4 
ENSMUST00000215937.2 1190001M18Rik ENSMUST00000215937.2 1190001M18Rik (from geneSymbol) BC023846 ENSMUST00000215937.1 uc288ave.1 uc288ave.2 uc288ave.1 uc288ave.2 
ENSMUST00000215945.2 Or9g4b ENSMUST00000215945.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR94) ENSMUST00000215945.1 Olfr1015 Or9g4b Q7TR94 Q7TR94_MOUSE uc289xpm.1 uc289xpm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xpm.1 uc289xpm.2 
ENSMUST00000215946.2 Gm47230 ENSMUST00000215946.2 Gm47230 (from geneSymbol) ENSMUST00000215946.1 uc292gqp.1 uc292gqp.2 uc292gqp.1 uc292gqp.2 
ENSMUST00000215947.2 Or1o1 ENSMUST00000215947.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRK4) ENSMUST00000215947.1 Olfr107 Or1o1 Q7TRK4 Q7TRK4_MOUSE uc289kzk.1 uc289kzk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kzk.1 uc289kzk.2 
ENSMUST00000215949.2 Or2d3b ENSMUST00000215949.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A0R4J8U2) A0A0R4J8U2 A0A0R4J8U2_MOUSE ENSMUST00000215949.1 Olfr1532 Olfr1532-ps1 Olfr709-ps1 Or2d3b uc291udm.1 uc291udm.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291udm.1 uc291udm.2 
ENSMUST00000215956.3 Or10g6 ENSMUST00000215956.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEU2) ENSMUST00000215956.1 ENSMUST00000215956.2 Olfr981 Or10g6 Q8VEU2 Q8VEU2_MOUSE uc009oyz.1 uc009oyz.2 uc009oyz.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oyz.1 uc009oyz.2 uc009oyz.3 
ENSMUST00000215962.2 Or2ak6 ENSMUST00000215962.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7MTY4) ENSMUST00000215962.1 L7MTY4 L7MTY4_MOUSE Olfr319 Or2ak6 uc287ykv.1 uc287ykv.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ykv.1 uc287ykv.2 
ENSMUST00000215971.2 Gm47468 ENSMUST00000215971.2 Gm47468 (from geneSymbol) ENSMUST00000215971.1 uc292ked.1 uc292ked.2 uc292ked.1 uc292ked.2 
ENSMUST00000215972.2 Or8i2 ENSMUST00000215972.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AVB5) A2AVB5 A2AVB5_MOUSE ENSMUST00000215972.1 Olfr1104 Or8i2 uc289xtp.1 uc289xtp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xtp.1 uc289xtp.2 
ENSMUST00000215975.3 Or4b1 ENSMUST00000215975.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGP3) ENSMUST00000215975.1 ENSMUST00000215975.2 Olfr1270 Or4b1 Q8VGP3 Q8VGP3_MOUSE uc289yff.1 uc289yff.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yff.1 uc289yff.2 
ENSMUST00000215978.3 Or5be3 ENSMUST00000215978.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR58) ENSMUST00000215978.1 ENSMUST00000215978.2 Olfr1105 Or5be3 Q7TR58 Q7TR58_MOUSE uc289xtq.1 uc289xtq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xtq.1 uc289xtq.2 
ENSMUST00000215984.3 Or8b12i ENSMUST00000215984.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGG4) ENSMUST00000215984.1 ENSMUST00000215984.2 Olfr870 Or8b12i Q8VGG4 Q8VGG4_MOUSE uc292evc.1 uc292evc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292evc.1 uc292evc.2 
ENSMUST00000215990.3 Gask1a ENSMUST00000215990.3 golgi associated kinase 1A, transcript variant 5 (from RefSeq NM_001408675.1) ENSMUST00000215990.1 ENSMUST00000215990.2 Fam198a GAK1A_MOUSE NM_001408675 Q3TYS0 Q3UTV8 Q3UY90 Q8C7H6 uc292mks.1 uc292mks.2 Secreted Endoplasmic reticulum Golgi apparatus Membrane, caveola Note=Requires caveolae biogenesis to be secreted from the endoplasmic reticulum going through the Golgi apparatus where is post-translationally processed to the mature form. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UY90-1; Sequence=Displayed; Name=2; IsoId=Q3UY90-2; Sequence=VSP_027885; Name=3; IsoId=Q3UY90-3; Sequence=VSP_027886; Expressed in tracheal serous gland, heart, muscle, fat, lung, ovary, liver, kidney, adrenal gland and brain (at protein level). Proteolytically cleaved. Cleaved at Arg-112 and Arg-424 leading to a processed mature product of 35 kDa. The cleavage takes place in the Golgi apparatus. Belongs to the GASK family. molecular_function extracellular region endoplasmic reticulum Golgi apparatus caveola biological_process membrane intracellular membrane-bounded organelle uc292mks.1 uc292mks.2 
ENSMUST00000215995.2 Or52m1 ENSMUST00000215995.2 Membrane ; Multi- pass membrane protein (from UniProt E9Q546) E9Q546 E9Q546_MOUSE ENSMUST00000215995.1 Olfr554 Or52m1 uc291tng.1 uc291tng.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tng.1 uc291tng.2 
ENSMUST00000215996.2 Or5d40 ENSMUST00000215996.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR25) ENSMUST00000215996.1 Olfr1168 Or5d40 Q7TR25 Q7TR25_MOUSE uc289xxo.1 uc289xxo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxo.1 uc289xxo.2 
ENSMUST00000216004.2 Gm38642 ENSMUST00000216004.2 Gm38642 (from geneSymbol) AK013799 ENSMUST00000216004.1 uc292mfc.1 uc292mfc.2 uc292mfc.1 uc292mfc.2 
ENSMUST00000216006.2 Or51k2 ENSMUST00000216006.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF02) ENSMUST00000216006.1 Olfr633 Or51k2 Q8VF02 Q8VF02_MOUSE uc291tsh.1 uc291tsh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tsh.1 uc291tsh.2 
ENSMUST00000216009.2 Or2ag1 ENSMUST00000216009.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EPF7) ENSMUST00000216009.1 Olfr705 Or2ag1 Q9EPF7 Q9EPF7_MOUSE uc291udc.1 uc291udc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291udc.1 uc291udc.2 
ENSMUST00000216017.3 Gm34829 ENSMUST00000216017.3 Gm34829 (from geneSymbol) ENSMUST00000216017.1 ENSMUST00000216017.2 uc292ize.1 uc292ize.2 uc292ize.3 uc292ize.1 uc292ize.2 uc292ize.3 
ENSMUST00000216020.2 Or8u10 ENSMUST00000216020.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR84) ENSMUST00000216020.1 Olfr1037 Or8u10 Q7TR84 Q7TR84_MOUSE uc289xqo.1 uc289xqo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xqo.1 uc289xqo.2 
ENSMUST00000216028.2 Or5al7 ENSMUST00000216028.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFK4) ENSMUST00000216028.1 Olfr1043 Or5al7 Q8VFK4 Q8VFK4_MOUSE uc289xqy.1 uc289xqy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xqy.1 uc289xqy.2 
ENSMUST00000216030.2 Or7a35 ENSMUST00000216030.2 Membrane ; Multi- pass membrane protein (from UniProt Q8VGU6) ENSMUST00000216030.1 Olfr1351 Or7a35 Q8VGU6 Q8VGU6_MOUSE uc287srb.1 uc287srb.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287srb.1 uc287srb.2 
ENSMUST00000216039.3 Or2ad1 ENSMUST00000216039.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFG3) ENSMUST00000216039.1 ENSMUST00000216039.2 Olfr1368 Or2ad1 Q8VFG3 Q8VFG3_MOUSE uc007ppx.1 uc007ppx.2 uc007ppx.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007ppx.1 uc007ppx.2 uc007ppx.3 
ENSMUST00000216051.3 Or2g1 ENSMUST00000216051.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFQ1) ENSMUST00000216051.1 ENSMUST00000216051.2 Olfr123 Or2g1 Q8VFQ1 Q8VFQ1_MOUSE uc289las.1 uc289las.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289las.1 uc289las.2 
ENSMUST00000216052.2 Gm47171 ENSMUST00000216052.2 Gm47171 (from geneSymbol) ENSMUST00000216052.1 LF197892 uc292mqs.1 uc292mqs.2 uc292mqs.1 uc292mqs.2 
ENSMUST00000216055.2 Gm48362 ENSMUST00000216055.2 Gm48362 (from geneSymbol) BC005512 ENSMUST00000216055.1 uc292fic.1 uc292fic.2 uc292fic.1 uc292fic.2 
ENSMUST00000216056.2 Or8k3 ENSMUST00000216056.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGS0) ENSMUST00000216056.1 Olfr1047 Olfr1082 Or8k3 Q8VGS0 Q8VGS0_MOUSE uc289xrg.1 uc289xrg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xrg.1 uc289xrg.2 
ENSMUST00000216063.2 Zfp445 ENSMUST00000216063.2 zinc finger protein 445, transcript variant 1 (from RefSeq NM_173364.6) A4FTX7 ENSMUST00000216063.1 NM_173364 Q8K216 Q8R2V3 ZN445_MOUSE Znf445 uc009sfe.1 uc009sfe.2 uc009sfe.3 Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but ZFP57 plays the predominant role in imprinting maintenance. In contrast, ZNF445 seems to be the major factor in human early embryonic imprinting maintenance (PubMed:30602440). Nucleus Note=Binds various differentially methylated regions (DMR). About one-third of zygotic mutants survived to adulthood. They do not exhibit any loss of methylation imprints at ICRs in the brain and liver at 12.5 dpc (PubMed:30602440). Double zygotic mutations of ZFP57 and ZNF445 are embryonically lethal and embryos show no gross morphological abnormalities but significant reduction in size and weight at 11.5 dpc, a phenotype more pronounced than in ZFP57 mutant mice with a more severe loss of impinting (PubMed:30602440). Belongs to the krueppel C2H2-type zinc-finger protein family. Sequence=AAH34572.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc009sfe.1 uc009sfe.2 uc009sfe.3 
ENSMUST00000216064.2 Gm47565 ENSMUST00000216064.2 Gm47565 (from geneSymbol) ENSMUST00000216064.1 uc292emp.1 uc292emp.2 uc292emp.1 uc292emp.2 
ENSMUST00000216067.3 Or6c211 ENSMUST00000216067.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEU1) ENSMUST00000216067.1 ENSMUST00000216067.2 Olfr801 Or6c211 Q8VEU1 Q8VEU1_MOUSE uc287vyp.1 uc287vyp.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vyp.1 uc287vyp.2 
ENSMUST00000216068.2 Gm47001 ENSMUST00000216068.2 Gm47001 (from geneSymbol) ENSMUST00000216068.1 uc292ekm.1 uc292ekm.2 uc292ekm.1 uc292ekm.2 
ENSMUST00000216069.2 Or4z4 ENSMUST00000216069.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFU9) ENSMUST00000216069.1 Olfr1427 Or4z4 Q8VFU9 Q8VFU9_MOUSE uc289rau.1 uc289rau.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rau.1 uc289rau.2 
ENSMUST00000216071.2 Or4f60 ENSMUST00000216071.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQW8) ENSMUST00000216071.1 Olfr1313 Or4f60 Q7TQW8 Q7TQW8_MOUSE uc289zgt.1 uc289zgt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zgt.1 uc289zgt.2 
ENSMUST00000216072.2 Cxcr6 ENSMUST00000216072.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1SVJ3) A0A1L1SVJ3 A0A1L1SVJ3_MOUSE BC096491 Cxcr6 ENSMUST00000216072.1 uc033joa.1 uc033joa.2 uc033joa.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity chemokine receptor activity chemotaxis inflammatory response signal transduction G-protein coupled receptor signaling pathway coreceptor activity membrane integral component of membrane C-X-C chemokine receptor activity chemokine-mediated signaling pathway uc033joa.1 uc033joa.2 uc033joa.3 
ENSMUST00000216074.2 Or51aa5 ENSMUST00000216074.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N609) ENSMUST00000216074.1 K7N609 K7N609_MOUSE Olfr611 Or51aa5 uc291tqr.1 uc291tqr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tqr.1 uc291tqr.2 
ENSMUST00000216075.2 Or51af1 ENSMUST00000216075.2 Membrane ; Multi- pass membrane protein (from UniProt E9Q4X7) E9Q4X7 E9Q4X7_MOUSE ENSMUST00000216075.1 Olfr609 Or51af1 uc291tqn.1 uc291tqn.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tqn.1 uc291tqn.2 
ENSMUST00000216082.2 Or8w1 ENSMUST00000216082.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG97) ENSMUST00000216082.1 Olfr1132 Or8w1 Q8VG97 Q8VG97_MOUSE uc289xvy.1 uc289xvy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xvy.1 uc289xvy.2 
ENSMUST00000216083.2 Or2b2b ENSMUST00000216083.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K9J6X0) ENSMUST00000216083.1 K9J6X0 K9J6X0_MOUSE Olfr1359 Olfr1360 Or2b2b uc288lfm.1 uc288lfm.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288lfm.1 uc288lfm.2 
ENSMUST00000216088.3 Or5aq7 ENSMUST00000216088.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TS20) ENSMUST00000216088.1 ENSMUST00000216088.2 Olfr259 Or5aq7 Q7TS20 Q7TS20_MOUSE uc289xtz.1 uc289xtz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xtz.1 uc289xtz.2 
ENSMUST00000216096.2 Gm31822 ENSMUST00000216096.2 Gm31822 (from geneSymbol) AK041693 ENSMUST00000216096.1 uc287udg.1 uc287udg.2 uc287udg.1 uc287udg.2 
ENSMUST00000216101.3 Or1ad1 ENSMUST00000216101.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGH1) ENSMUST00000216101.1 ENSMUST00000216101.2 Olfr1377 Or1ad1 Q8VGH1 Q8VGH1_MOUSE uc007iti.1 uc007iti.2 uc007iti.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007iti.1 uc007iti.2 uc007iti.3 
ENSMUST00000216111.3 Or4x13 ENSMUST00000216111.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1SQ02) A0A1L1SQ02 A0A1L1SQ02_MOUSE ENSMUST00000216111.1 ENSMUST00000216111.2 Olfr1274 Olfr1274-ps Or4x13 uc289yfs.1 uc289yfs.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yfs.1 uc289yfs.2 
ENSMUST00000216113.2 Gm47159 ENSMUST00000216113.2 Gm47159 (from geneSymbol) AK157506 ENSMUST00000216113.1 uc292mpo.1 uc292mpo.2 uc292mpo.1 uc292mpo.2 
ENSMUST00000216114.3 Or4f7 ENSMUST00000216114.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AVW1) A2AVW1 A2AVW1_MOUSE ENSMUST00000216114.1 ENSMUST00000216114.2 Olfr1303 Or4f7 uc289zfv.1 uc289zfv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zfv.1 uc289zfv.2 
ENSMUST00000216116.4 Or55b10 ENSMUST00000216116.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9WU94) ENSMUST00000216116.1 ENSMUST00000216116.2 ENSMUST00000216116.3 Olfr545 Or55b10 Q9WU94 Q9WU94_MOUSE uc291tmr.1 uc291tmr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tmr.1 uc291tmr.2 
ENSMUST00000216117.2 Or5t18 ENSMUST00000216117.2 olfactory receptor family 5 subfamily T member 18 (from RefSeq NM_181818.2) A0A1L1STV1 A0A1L1STV1_MOUSE ENSMUST00000216117.1 NM_181818 Olfr141 Or5t18 uc008kmy.1 uc008kmy.2 uc008kmy.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kmy.1 uc008kmy.2 uc008kmy.3 
ENSMUST00000216118.3 Or2ag1b ENSMUST00000216118.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N641) ENSMUST00000216118.1 ENSMUST00000216118.2 F6VBP6 K7N641 K7N641_MOUSE Olfr694 Olfr698 Olfr706 Or2ag1b uc291ucj.1 uc291ucj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ucj.1 uc291ucj.2 
ENSMUST00000216121.3 Or4p19 ENSMUST00000216121.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q0VB29) ENSMUST00000216121.1 ENSMUST00000216121.2 Olfr1180 Or4p19 Q0VB29 Q0VB29_MOUSE uc289xyg.1 uc289xyg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xyg.1 uc289xyg.2 
ENSMUST00000216122.2 Gm20276 ENSMUST00000216122.2 Gm20276 (from geneSymbol) ENSMUST00000216122.1 uc287qho.1 uc287qho.2 uc287qho.1 uc287qho.2 
ENSMUST00000216123.2 Or4a68 ENSMUST00000216123.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG73) ENSMUST00000216123.1 Olfr1240 Or4a68 Q8VG73 Q8VG73_MOUSE uc289ycm.1 uc289ycm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ycm.1 uc289ycm.2 
ENSMUST00000216124.3 Or4a76 ENSMUST00000216124.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7MU51) ENSMUST00000216124.1 ENSMUST00000216124.2 L7MU51 L7MU51_MOUSE Olfr1249 Or4a76 uc289ydb.1 uc289ydb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ydb.1 uc289ydb.2 
ENSMUST00000216128.2 Or14j10 ENSMUST00000216128.2 Odorant receptor. (from UniProt Q923Q6) ENSMUST00000216128.1 Olfr116 Or14j10 Q923Q6 Q923Q6_MOUSE uc289lag.1 uc289lag.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lag.1 uc289lag.2 
ENSMUST00000216129.2 Or4a75 ENSMUST00000216129.2 olfactory receptor family 4 subfamily A member 75 (from RefSeq NM_146791.2) A0A1L1SSZ5 A0A1L1SSZ5_MOUSE ENSMUST00000216129.1 NM_146791 Olfr1248 Or4a75 uc008krt.1 uc008krt.2 uc008krt.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC150718.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008krt.1 uc008krt.2 uc008krt.3 
ENSMUST00000216130.2 Abhd14b ENSMUST00000216130.2 Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:45950; Evidence=; (from UniProt E9QN99) A0A087WQN8 Abhd14b BC019410 E9QN99 E9QN99_MOUSE ENSMUST00000216130.1 uc292kpg.1 uc292kpg.2 Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:45950; Evidence=; May interact with TAF1. Cytoplasm Nucleus Belongs to the AB hydrolase superfamily. ABHD14 family. nucleus nucleolus cytosol hydrolase activity positive regulation of transcription from RNA polymerase II promoter uc292kpg.1 uc292kpg.2 
ENSMUST00000216132.2 Or8g30 ENSMUST00000216132.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EQ95) ENSMUST00000216132.1 Olfr948 Or8g30 Q9EQ95 Q9EQ95_MOUSE uc292gau.1 uc292gau.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gau.1 uc292gau.2 
ENSMUST00000216139.3 Akap12 ENSMUST00000216139.3 Akap12 (from geneSymbol) A0A668KLD3 A0A668KLD3_MOUSE AB070853 Akap12 ENSMUST00000216139.1 ENSMUST00000216139.2 mCG_140773 uc287pgm.1 uc287pgm.2 uc287pgm.1 uc287pgm.2 
ENSMUST00000216143.2 Or52x1 ENSMUST00000216143.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGX3) ENSMUST00000216143.1 Olfr686 Or52x1 Q8VGX3 Q8VGX3_MOUSE uc291txd.1 uc291txd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291txd.1 uc291txd.2 
ENSMUST00000216144.3 Or4c1 ENSMUST00000216144.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQZ8) ENSMUST00000216144.1 ENSMUST00000216144.2 Olfr1231 Or4c1 Q7TQZ8 Q7TQZ8_MOUSE uc289yby.1 uc289yby.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yby.1 uc289yby.2 
ENSMUST00000216147.3 A830035O19Rik ENSMUST00000216147.3 RIKEN cDNA A830035O19 gene (from RefSeq NR_152206.1) ENSMUST00000216147.1 ENSMUST00000216147.2 NR_152206 uc292gxn.1 uc292gxn.2 uc292gxn.3 uc292gxn.1 uc292gxn.2 uc292gxn.3 
ENSMUST00000216157.2 Or2m12 ENSMUST00000216157.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF87) ENSMUST00000216157.1 Olfr164 Or2m12 Q8VF87 Q8VF87_MOUSE uc007yot.1 uc007yot.2 uc007yot.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007yot.1 uc007yot.2 uc007yot.3 
ENSMUST00000216158.2 Gm48830 ENSMUST00000216158.2 Gm48830 (from geneSymbol) ENSMUST00000216158.1 uc292jhc.1 uc292jhc.2 uc292jhc.1 uc292jhc.2 
ENSMUST00000216159.2 Gm48720 ENSMUST00000216159.2 Gm48720 (from geneSymbol) AK039797 ENSMUST00000216159.1 uc292gtv.1 uc292gtv.2 uc292gtv.1 uc292gtv.2 
ENSMUST00000216161.2 ENSMUSG00000121634 ENSMUST00000216161.2 ENSMUSG00000121634 (from geneSymbol) ENSMUST00000216161.1 uc287qje.1 uc287qje.2 uc287qje.1 uc287qje.2 
ENSMUST00000216168.2 Or8c10 ENSMUST00000216168.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1STR2) A0A1L1STR2 A0A1L1STR2_MOUSE ENSMUST00000216168.1 Olfr250 Or8c10 uc292fxw.1 uc292fxw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fxw.1 uc292fxw.2 
ENSMUST00000216170.2 Gm33699 ENSMUST00000216170.2 Gm33699 (from geneSymbol) ENSMUST00000216170.1 uc292hxk.1 uc292hxk.2 uc292hxk.1 uc292hxk.2 
ENSMUST00000216172.2 Ncoa7 ENSMUST00000216172.2 nuclear receptor coactivator 7, transcript variant 2 (from RefSeq NM_001111267.2) ENSMUST00000216172.1 NCOA7_MOUSE NM_001111267 Q3TAR1 Q3UNB3 Q66K05 Q6DFV7 Q6ZQM4 Q8BJ15 Q8BJ39 uc007eti.1 uc007eti.2 uc007eti.3 uc007eti.4 Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA (By similarity). Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the heterodimer AHR-ARNT (By similarity). Nucleus Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q6DFV7-1; Sequence=Displayed; Name=2; IsoId=Q6DFV7-2; Sequence=VSP_019641, VSP_019642; Name=3; IsoId=Q6DFV7-3; Sequence=VSP_019640, VSP_019643; Name=4; IsoId=Q6DFV7-4; Sequence=VSP_019640, VSP_019643, VSP_019648; Name=5; IsoId=Q6DFV7-5; Sequence=VSP_019640, VSP_019643, VSP_019644, VSP_019647; Name=6; IsoId=Q6DFV7-6; Sequence=VSP_019640, VSP_019643, VSP_019645, VSP_019646; Highly expressed in brain and kidney. Weakly expressed in mammary gland, lung and testis. In brain, expression is found in neurons of cerebral cortex, thalamus, hypothalamus, hippocampus, cerebellum, striatum and choroid plexus. Belongs to the OXR1 family. Sequence=BAC87660.1; Type=Frameshift; Evidence=; nucleus ligand-dependent nuclear receptor transcription coactivator activity nuclear hormone receptor binding positive regulation of transcription from RNA polymerase II promoter negative regulation of cellular response to oxidative stress negative regulation of peptidyl-cysteine S-nitrosylation negative regulation of oxidative stress-induced neuron death uc007eti.1 uc007eti.2 uc007eti.3 uc007eti.4 
ENSMUST00000216177.2 Or8g36 ENSMUST00000216177.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EQB7) ENSMUST00000216177.1 Olfr957 Or8g36 Q9EQB7 Q9EQB7_MOUSE uc292gbf.1 uc292gbf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gbf.1 uc292gbf.2 
ENSMUST00000216179.2 Or2a7 ENSMUST00000216179.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q0VAZ7) ENSMUST00000216179.1 Olfr13 Or2a7 Q0VAZ7 Q0VAZ7_MOUSE uc009bsi.1 uc009bsi.2 uc009bsi.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009bsi.1 uc009bsi.2 uc009bsi.3 
ENSMUST00000216180.2 Or5bs2 ENSMUST00000216180.2 olfactory receptor family 5 subfamily BS member 2 (from RefSeq NM_001424195.1) A0A286YDM5 A0A286YDM5_MOUSE ENSMUST00000216180.1 NM_001424195 uc289bav.1 uc289bav.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289bav.1 uc289bav.2 
ENSMUST00000216181.2 Or14j2 ENSMUST00000216181.2 olfactory receptor family 14 subfamily J member 2 (from RefSeq NM_146289.1) ENSMUST00000216181.1 NM_146289 Olfr113 Or14j2 Q8VEU4 Q8VEU4_MOUSE uc008cne.1 uc008cne.2 uc008cne.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC132178.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008cne.1 uc008cne.2 uc008cne.3 
ENSMUST00000216182.2 Or6c217 ENSMUST00000216182.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRH3) ENSMUST00000216182.1 Olfr815 Or6c217 Q7TRH3 Q7TRH3_MOUSE uc287vzt.1 uc287vzt.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vzt.1 uc287vzt.2 
ENSMUST00000216185.3 Or8k18 ENSMUST00000216185.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2ARZ0) A2ARZ0 A2ARZ0_MOUSE ENSMUST00000216185.1 ENSMUST00000216185.2 Olfr1049 Olfr1051 Or8k18 uc008klz.1 uc008klz.2 uc008klz.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008klz.1 uc008klz.2 uc008klz.3 
ENSMUST00000216191.2 Or5l13 ENSMUST00000216191.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AVC3) A2AVC3 A2AVC3_MOUSE ENSMUST00000216191.1 Olfr1156 Or5l13 uc289xxd.1 uc289xxd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxd.1 uc289xxd.2 
ENSMUST00000216193.2 Gm47232 ENSMUST00000216193.2 Gm47232 (from geneSymbol) ENSMUST00000216193.1 uc292gqr.1 uc292gqr.2 uc292gqr.1 uc292gqr.2 
ENSMUST00000216195.2 Or4n4b ENSMUST00000216195.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q14AK5) ENSMUST00000216195.1 Olfr733 Or4n4b Q14AK5 Q14AK5_MOUSE uc288tlc.1 uc288tlc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tlc.1 uc288tlc.2 
ENSMUST00000216196.2 Or2w3b ENSMUST00000216196.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5NCD6) ENSMUST00000216196.1 Olfr179 Olfr317 Or2w3b Q5NCD6 Q5NCD6_MOUSE uc287yla.1 uc287yla.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287yla.1 uc287yla.2 
ENSMUST00000216202.2 Or6s1 ENSMUST00000216202.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q0Z1) E9Q0Z1 E9Q0Z1_MOUSE ENSMUST00000216202.1 Olfr750 Or6s1 uc288toh.1 uc288toh.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288toh.1 uc288toh.2 
ENSMUST00000216203.2 Or4a79 ENSMUST00000216203.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQZ2) A0A087WQ53 ENSMUST00000216203.1 Olfr1252 Or4a79 Q7TQZ2 Q7TQZ2_MOUSE uc289ydg.1 uc289ydg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ydg.1 uc289ydg.2 
ENSMUST00000216204.2 Gm35371 ENSMUST00000216204.2 Gm35371 (from geneSymbol) ENSMUST00000216204.1 uc292geh.1 uc292geh.2 uc292geh.1 uc292geh.2 
ENSMUST00000216206.2 Gm48717 ENSMUST00000216206.2 Gm48717 (from geneSymbol) AK042533 ENSMUST00000216206.1 uc292fue.1 uc292fue.2 uc292fue.1 uc292fue.2 
ENSMUST00000216211.2 H60c ENSMUST00000216211.2 H60c (from geneSymbol) A0A1L1SRI2 A0A1L1SRI2_MOUSE AB284506 ENSMUST00000216211.1 H60c uc287pft.1 uc287pft.2 membrane integral component of membrane uc287pft.1 uc287pft.2 
ENSMUST00000216213.2 Or4c11b ENSMUST00000216213.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGF5) ENSMUST00000216213.1 Olfr1201 Or4c11b Q8VGF5 Q8VGF5_MOUSE uc289xzo.1 uc289xzo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xzo.1 uc289xzo.2 
ENSMUST00000216214.2 Or6e1 ENSMUST00000216214.2 Odorant receptor. Activated by (-)-citronellal and to a lesser extent by (+)-citronellal. Not activated by carvone or limonene. (from UniProt Q9Z1V0) ENSMUST00000216214.1 Mor118-1 OR6E1_MOUSE Olfr49 Or6e1 Q8VFB7 Q9Z1V0 uc288ueu.1 uc288ueu.2 Odorant receptor. Activated by (-)-citronellal and to a lesser extent by (+)-citronellal. Not activated by carvone or limonene. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane isoprenoid binding response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288ueu.1 uc288ueu.2 
ENSMUST00000216217.2 Gm47887 ENSMUST00000216217.2 Gm47887 (from geneSymbol) AK078683 ENSMUST00000216217.1 uc292hjn.1 uc292hjn.2 uc292hjn.1 uc292hjn.2 
ENSMUST00000216221.2 Gm47380 ENSMUST00000216221.2 Gm47380 (from geneSymbol) ENSMUST00000216221.1 uc287rao.1 uc287rao.2 uc287rao.1 uc287rao.2 
ENSMUST00000216224.2 Usp44 ENSMUST00000216224.2 ubiquitin specific peptidase 44, transcript variant 3 (from RefSeq NM_001400981.1) ENSMUST00000216224.1 NM_001400981 Q8C2S0 UBP44_MOUSE uc287uey.1 uc287uey.2 Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset (PubMed:23187126). Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Promotes also the deubiquitination of histone H2A and H2B. Recruited to RNF8/RNF168-ubiquitinated chromatin surrounding double stranded breaks (DSBs), promotes hydrolysis of such ubiquitin conjugates, thus negatively regulating protein recruitment to damaged chromatin (By similarity). Participates in nucleotide excision repair (NER) pathway by deubiquitinating DDB2 to prevent its premature degradation so it can remain on damaged chromatin (PubMed:23187126). Promotes FOXP3 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability and increased regulatory T-cell lineage stability. Plays also a positive role in innate immune response to DNA viruses by deubiquitinating STING1, selectively removing its 'Lys-48'- linked polyubiquitin chains and stabilizing it (By similarity). Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence= Interacts with the N-CoR components TBL1X and TBL1XR1. Q8C2S0; Q99JB6: Foxp3; NbExp=3; IntAct=EBI-26303241, EBI-10956246; Nucleus Cytoplasm Note=Peaks in interphase, with relatively low levels maintained throughout mitosis. Widely expressed. Highly expressed in lung, pancreas, skin, liver, stomach and intestine. Dephosphorylated by CTDP1. Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination and is degraded by the proteasome. USP44-deficient mice show a significant increase in skin tumors when compared to wild-type mice (PubMed:33937266). In addition, they are prone to development of spontaneous tumors, particularly in the lungs (PubMed:23187126). USP44 loss causes also chromosome mis-segregation and aneuploidy (PubMed:23187126). Belongs to the peptidase C19 family. USP44 subfamily. Sequence=AAI11887.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAC40148.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; thiol-dependent ubiquitin-specific protease activity nucleus proteolysis ubiquitin-dependent protein catabolic process cell cycle chromosome segregation peptidase activity cysteine-type peptidase activity zinc ion binding protein deubiquitination hydrolase activity thiol-dependent ubiquitinyl hydrolase activity proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding cell division regulation of mitotic cell cycle spindle assembly checkpoint negative regulation of ubiquitin protein ligase activity uc287uey.1 uc287uey.2 
ENSMUST00000216226.2 Or13p4 ENSMUST00000216226.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFY3) ENSMUST00000216226.1 Olfr1342 Or13p4 Q8VFY3 Q8VFY3_MOUSE uc008ukq.1 uc008ukq.2 uc008ukq.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008ukq.1 uc008ukq.2 uc008ukq.3 
ENSMUST00000216230.2 Or52b1 ENSMUST00000216230.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VH18) A0A1B0GR80 ENSMUST00000216230.1 Olfr690 Or52b1 Q8VH18 Q8VH18_MOUSE uc291txk.1 uc291txk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291txk.1 uc291txk.2 
ENSMUST00000216235.2 Gm48833 ENSMUST00000216235.2 Gm48833 (from geneSymbol) ENSMUST00000216235.1 uc292jhi.1 uc292jhi.2 uc292jhi.1 uc292jhi.2 
ENSMUST00000216236.2 Gm47772 ENSMUST00000216236.2 Gm47772 (from geneSymbol) ENSMUST00000216236.1 uc292fgv.1 uc292fgv.2 uc292fgv.1 uc292fgv.2 
ENSMUST00000216237.2 Gm47068 ENSMUST00000216237.2 Gm47068 (from geneSymbol) ENSMUST00000216237.1 uc292mgi.1 uc292mgi.2 uc292mgi.1 uc292mgi.2 
ENSMUST00000216238.3 Or8d1b ENSMUST00000216238.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EQA0) A0A1L1SR30 ENSMUST00000216238.1 ENSMUST00000216238.2 Olfr933 Or8d1b Q9EQA0 Q9EQA0_MOUSE uc009oxk.1 uc009oxk.2 uc009oxk.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oxk.1 uc009oxk.2 uc009oxk.3 
ENSMUST00000216242.3 Or13p8 ENSMUST00000216242.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q3KPC7) A0A1L1STT8 ENSMUST00000216242.1 ENSMUST00000216242.2 Olfr1340 Or13p8 Q3KPC7 Q3KPC7_MOUSE uc290pim.1 uc290pim.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc290pim.1 uc290pim.2 
ENSMUST00000216247.2 Or56a3b ENSMUST00000216247.2 Membrane ; Multi- pass membrane protein (from UniProt Q3SXH8) ENSMUST00000216247.1 Olfr681 Or56a3b Q3SXH8 Q3SXH8_MOUSE uc291two.1 uc291two.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291two.1 uc291two.2 
ENSMUST00000216249.2 Or14j3 ENSMUST00000216249.2 Odorant receptor. (from UniProt Q923Q8) ENSMUST00000216249.1 Olfr114 Or14j3 Q923Q8 Q923Q8_MOUSE uc289lab.1 uc289lab.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lab.1 uc289lab.2 
ENSMUST00000216254.2 Or2ag19 ENSMUST00000216254.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EPF5) ENSMUST00000216254.1 Olfr703 Or2ag19 Q9EPF5 Q9EPF5_MOUSE uc291ucx.1 uc291ucx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ucx.1 uc291ucx.2 
ENSMUST00000216255.2 Or2ag16 ENSMUST00000216255.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRN4) ENSMUST00000216255.1 Olfr698 Or2ag16 Q7TRN4 Q7TRN4_MOUSE uc291ucq.1 uc291ucq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ucq.1 uc291ucq.2 
ENSMUST00000216257.2 Or52n3 ENSMUST00000216257.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG79) ENSMUST00000216257.1 Olfr665 Or52n3 Q8VG79 Q8VG79_MOUSE uc291tvf.1 uc291tvf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tvf.1 uc291tvf.2 
ENSMUST00000216259.2 Or1f19 ENSMUST00000216259.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGB9) ENSMUST00000216259.1 Olfr161 Or1f19 Q8VGB9 Q8VGB9_MOUSE uc289bzf.1 uc289bzf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289bzf.1 uc289bzf.2 
ENSMUST00000216261.2 Or5ac22 ENSMUST00000216261.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q8M0) E9Q8M0 E9Q8M0_MOUSE ENSMUST00000216261.1 Olfr204 Or5ac22 uc289fgt.1 uc289fgt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289fgt.1 uc289fgt.2 
ENSMUST00000216269.2 Gm34425 ENSMUST00000216269.2 Gm34425 (from geneSymbol) ENSMUST00000216269.1 uc292mgl.1 uc292mgl.2 uc292mgl.1 uc292mgl.2 
ENSMUST00000216270.3 Gm16845 ENSMUST00000216270.3 predicted gene, 16845, transcript variant 1 (from RefSeq NR_040406.1) ENSMUST00000216270.1 ENSMUST00000216270.2 NR_040406 uc029wxz.1 uc029wxz.2 uc029wxz.3 uc029wxz.4 uc029wxz.1 uc029wxz.2 uc029wxz.3 uc029wxz.4 
ENSMUST00000216271.3 Or4c110 ENSMUST00000216271.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A3KGY3) A0A087WSP6 A3KGY3 A3KGY3_MOUSE ENSMUST00000216271.1 ENSMUST00000216271.2 Olfr1215 Olfr1222 Or4c110 uc289yaf.1 uc289yaf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yaf.1 uc289yaf.2 
ENSMUST00000216273.2 Or2o1 ENSMUST00000216273.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VET2) ENSMUST00000216273.1 Olfr1394 Or2o1 Q8VET2 Q8VET2_MOUSE uc287xsl.1 uc287xsl.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xsl.1 uc287xsl.2 
ENSMUST00000216275.2 Or1j14 ENSMUST00000216275.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGK7) ENSMUST00000216275.1 Olfr342 Or1j14 Q8VGK7 Q8VGK7_MOUSE uc008jlr.1 uc008jlr.2 uc008jlr.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008jlr.1 uc008jlr.2 uc008jlr.3 
ENSMUST00000216276.2 Or8c18 ENSMUST00000216276.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1SRZ8) A0A1L1SRZ8 A0A1L1SRZ8_MOUSE ENSMUST00000216276.1 Olfr896 Or8c18 uc292fxo.1 uc292fxo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fxo.1 uc292fxo.2 
ENSMUST00000216279.2 Gm47161 ENSMUST00000216279.2 Gm47161 (from geneSymbol) ENSMUST00000216279.1 uc292hac.1 uc292hac.2 uc292hac.1 uc292hac.2 
ENSMUST00000216286.2 Neto2 ENSMUST00000216286.2 neuropilin (NRP) and tolloid (TLL)-like 2, transcript variant 2 (from RefSeq NM_001357288.1) B2RX93 Btcl2 ENSMUST00000216286.1 NETO2_MOUSE NM_001357288 Q5VM49 Q8BNJ6 Q8C4Q8 uc009mqe.1 uc009mqe.2 uc009mqe.3 uc009mqe.4 Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity). Interacts with GRIK2 and GRIK3, but neither with AMPA-nor with NMDA-sensitive glutamate receptors. [Isoform 1]: Cell membrane ; Single- pass type I membrane protein [Isoform 2]: Cell membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BNJ6-1; Sequence=Displayed; Name=2; IsoId=Q8BNJ6-2; Sequence=VSP_012858, VSP_012859; Expressed in brain tissues, including cerebellar granule cells (at protein level). Observed restrictively in brain throughout embryonic (E) and postnatal stages (P). Expression pattern in brain slightly changes from 13 dpc to P21. N-glycosylated. Sequence=BAC38225.1; Type=Erroneous initiation; Evidence=; plasma membrane postsynaptic density membrane integral component of membrane ionotropic glutamate receptor binding synapse regulation of kainate selective glutamate receptor activity uc009mqe.1 uc009mqe.2 uc009mqe.3 uc009mqe.4 
ENSMUST00000216291.2 Or1e1f ENSMUST00000216291.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEZ6) B2FDE2 ENSMUST00000216291.1 Olfr23 Olfr397 Or1e1f Q8VEZ6 Q8VEZ6_MOUSE uc288aaq.1 uc288aaq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288aaq.1 uc288aaq.2 
ENSMUST00000216303.2 Or51b4 ENSMUST00000216303.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt F8VQ01) ENSMUST00000216303.1 F8VQ01 F8VQ01_MOUSE Olfr66 Or51b4 uc291tsa.1 uc291tsa.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tsa.1 uc291tsa.2 
ENSMUST00000216305.2 Gm46999 ENSMUST00000216305.2 Gm46999 (from geneSymbol) ENSMUST00000216305.1 uc292kiv.1 uc292kiv.2 uc292kiv.1 uc292kiv.2 
ENSMUST00000216307.2 Or2ag17 ENSMUST00000216307.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRN3) ENSMUST00000216307.1 Olfr699 Or2ag17 Q7TRN3 Q7TRN3_MOUSE uc291ucs.1 uc291ucs.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ucs.1 uc291ucs.2 
ENSMUST00000216311.2 4930534H03Rik ENSMUST00000216311.2 4930534H03Rik (from geneSymbol) AK015963 ENSMUST00000216311.1 uc287ubv.1 uc287ubv.2 uc287ubv.1 uc287ubv.2 
ENSMUST00000216312.2 Or51a39 ENSMUST00000216312.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGX7) ENSMUST00000216312.1 Olfr33 Or51a39 Q8VGX7 Q8VGX7_MOUSE uc291tnr.1 uc291tnr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tnr.1 uc291tnr.2 
ENSMUST00000216318.2 Or10c1 ENSMUST00000216318.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFE2) ENSMUST00000216318.1 Olfr95 Or10c1 Q8VFE2 Q8VFE2_MOUSE uc289kyh.1 uc289kyh.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kyh.1 uc289kyh.2 
ENSMUST00000216321.3 Gm47204 ENSMUST00000216321.3 Gm47204 (from geneSymbol) AK034734 ENSMUST00000216321.1 ENSMUST00000216321.2 uc292gqf.1 uc292gqf.2 uc292gqf.3 uc292gqf.1 uc292gqf.2 uc292gqf.3 
ENSMUST00000216328.2 Or1o4 ENSMUST00000216328.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFE4) ENSMUST00000216328.1 Olfr99 Or1o4 Q8VFE4 Q8VFE4_MOUSE uc289kyu.1 uc289kyu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kyu.1 uc289kyu.2 
ENSMUST00000216335.2 Or6b6 ENSMUST00000216335.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EPG2) A0A140LHW1 ENSMUST00000216335.1 Olfr711 Or6b6 Q9EPG2 Q9EPG2_MOUSE uc291udt.1 uc291udt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291udt.1 uc291udt.2 
ENSMUST00000216341.2 Or2h2c ENSMUST00000216341.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N475) ENSMUST00000216341.1 L7N475 L7N475_MOUSE Olfr92 Or2h2c uc289kxu.1 uc289kxu.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kxu.1 uc289kxu.2 
ENSMUST00000216344.2 Prkcsh ENSMUST00000216344.2 Prkcsh (from geneSymbol) AK153931 ENSMUST00000216344.1 Prkcsh Q3U518 Q3U518_MOUSE uc009oni.1 uc009oni.2 uc009oni.3 uc009oni.4 calcium ion binding N-glycan processing kinase activity phosphorylation uc009oni.1 uc009oni.2 uc009oni.3 uc009oni.4 
ENSMUST00000216346.3 Or6n1 ENSMUST00000216346.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRW1) ENSMUST00000216346.1 ENSMUST00000216346.2 Olfr429 Or6n1 Q7TRW1 Q7TRW1_MOUSE uc287oca.1 uc287oca.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287oca.1 uc287oca.2 
ENSMUST00000216347.2 Or5ak4 ENSMUST00000216347.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRA2) ENSMUST00000216347.1 Olfr987 Or5ak4 Q7TRA2 Q7TRA2_MOUSE uc008kkd.1 uc008kkd.2 uc008kkd.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kkd.1 uc008kkd.2 uc008kkd.3 
ENSMUST00000216362.2 Or1d2 ENSMUST00000216362.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRW7) ENSMUST00000216362.1 Olfr412 Or1d2 Q7TRW7 Q7TRW7_MOUSE uc288acc.1 uc288acc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane identical protein binding response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288acc.1 uc288acc.2 
ENSMUST00000216364.4 Or10ag54 ENSMUST00000216364.4 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1SRZ5) A0A1L1SRZ5 A0A1L1SRZ5_MOUSE ENSMUST00000216364.1 ENSMUST00000216364.2 ENSMUST00000216364.3 Olfr1116 Or10ag54 uc289xup.1 uc289xup.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xup.1 uc289xup.2 
ENSMUST00000216367.2 Or5ae1 ENSMUST00000216367.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TS13) ENSMUST00000216367.1 Olfr290 Or5ae1 Q7TS13 Q7TS13_MOUSE uc291sft.1 uc291sft.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291sft.1 uc291sft.2 
ENSMUST00000216372.2 Ankrd49 ENSMUST00000216372.2 ankyrin repeat domain 49, transcript variant 1 (from RefSeq NM_019683.4) ANR49_MOUSE ENSMUST00000216372.1 Fgif Gbif NM_019683 Q8VE42 Q9Z2S1 uc009ofb.1 uc009ofb.2 uc009ofb.3 May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway. Nucleus Expressed in spermatogonia, spermatocytes and round spermatids. Expressed in liver at embryonic stage 13 dpc, and in liver, brain and lung at 16 dpc (PubMed:11162141). In testis, expression levels steadily increase from 1 week after birth and plateau by 8 weeks after birth (PubMed:26043108). molecular_function cellular_component nucleus spermatogenesis cell differentiation positive regulation of transcription, DNA-templated uc009ofb.1 uc009ofb.2 uc009ofb.3 
ENSMUST00000216374.2 Gm47923 ENSMUST00000216374.2 Gm47923 (from geneSymbol) ENSMUST00000216374.1 uc292hxi.1 uc292hxi.2 uc292hxi.1 uc292hxi.2 
ENSMUST00000216377.2 Or10q1b ENSMUST00000216377.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEZ5) ENSMUST00000216377.1 Olfr1491 Or10q1b Q8VEZ5 Q8VEZ5_MOUSE uc289rgm.1 uc289rgm.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rgm.1 uc289rgm.2 
ENSMUST00000216378.2 Or5as1 ENSMUST00000216378.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR55) ENSMUST00000216378.1 Olfr1111 Or5as1 Q7TR55 Q7TR55_MOUSE uc289xud.1 uc289xud.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xud.1 uc289xud.2 
ENSMUST00000216383.2 Or4b12 ENSMUST00000216383.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG62) ENSMUST00000216383.1 Olfr1271 Or4b12 Q8VG62 Q8VG62_MOUSE uc289yfl.1 uc289yfl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yfl.1 uc289yfl.2 
ENSMUST00000216389.2 Gm47875 ENSMUST00000216389.2 Gm47875 (from geneSymbol) AK076649 ENSMUST00000216389.1 uc292lwo.1 uc292lwo.2 uc292lwo.1 uc292lwo.2 
ENSMUST00000216396.3 Or10ag56 ENSMUST00000216396.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1STN9) A0A1L1STN9 A0A1L1STN9_MOUSE ENSMUST00000216396.1 ENSMUST00000216396.2 Olfr1118 Or10ag56 uc289xut.1 uc289xut.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xut.1 uc289xut.2 
ENSMUST00000216397.3 Or9g19 ENSMUST00000216397.3 Odorant receptor. (from UniProt Q7TR96) ENSMUST00000216397.1 ENSMUST00000216397.2 Mor213-2 O9G19_MOUSE Olfr1013 Or9g19 Q7TR96 Q8VG30 uc289xpi.1 uc289xpi.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xpi.1 uc289xpi.2 
ENSMUST00000216407.2 Or5af1 ENSMUST00000216407.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRZ9) ENSMUST00000216407.1 Olfr312 Or5af1 Q7TRZ9 Q7TRZ9_MOUSE uc287ylf.1 uc287ylf.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ylf.1 uc287ylf.2 
ENSMUST00000216408.2 Or2a25 ENSMUST00000216408.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGP6) ENSMUST00000216408.1 Olfr447 Or2a25 Q8VGP6 Q8VGP6_MOUSE uc291dzi.1 uc291dzi.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dzi.1 uc291dzi.2 
ENSMUST00000216409.2 Or6aa1 ENSMUST00000216409.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFP0) ENSMUST00000216409.1 Olfr303 Or6aa1 Q8VFP0 Q8VFP0_MOUSE uc291sjb.1 uc291sjb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291sjb.1 uc291sjb.2 
ENSMUST00000216411.2 Or2a14 ENSMUST00000216411.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K9J725) ENSMUST00000216411.1 K9J725 K9J725_MOUSE Olfr237 Olfr237-ps1 Or2a14 uc291dzu.1 uc291dzu.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dzu.1 uc291dzu.2 
ENSMUST00000216419.2 Gm47066 ENSMUST00000216419.2 Gm47066 (from geneSymbol) AK135884 ENSMUST00000216419.1 uc292mgf.1 uc292mgf.2 uc292mgf.1 uc292mgf.2 
ENSMUST00000216420.2 Or51a6 ENSMUST00000216420.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRS3) ENSMUST00000216420.1 Olfr575 Or51a6 Q7TRS3 Q7TRS3_MOUSE uc291too.1 uc291too.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291too.1 uc291too.2 
ENSMUST00000216421.2 Or4f52 ENSMUST00000216421.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQY8) ENSMUST00000216421.1 Olfr1275 Or4f52 Q7TQY8 Q7TQY8_MOUSE uc289zea.1 uc289zea.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zea.1 uc289zea.2 
ENSMUST00000216422.3 Gm40638 ENSMUST00000216422.3 Gm40638 (from geneSymbol) ENSMUST00000216422.1 ENSMUST00000216422.2 uc287qyk.1 uc287qyk.2 uc287qyk.3 uc287qyk.1 uc287qyk.2 uc287qyk.3 
ENSMUST00000216432.2 Or8k20 ENSMUST00000216432.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR76) ENSMUST00000216432.1 Olfr1051 Or8k20 Q7TR76 Q7TR76_MOUSE uc289xrm.1 uc289xrm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xrm.1 uc289xrm.2 
ENSMUST00000216433.2 Cyp1a1 ENSMUST00000216433.2 cytochrome P450, family 1, subfamily a, polypeptide 1, transcript variant 1 (from RefSeq NM_009992.4) Cyp1a1 ENSMUST00000216433.1 NM_009992 Q05A20 Q05A20_MOUSE uc009pvn.1 uc009pvn.2 uc009pvn.3 uc009pvn.4 uc009pvn.5 Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo- (5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37947, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37948; Evidence=; Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)- octadecadienoate + H2O; Xref=Rhea:RHEA:48716, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:90781; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48717; Evidence=; Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo- (5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48637; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)- docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52120, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136410; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52121; Evidence=; Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo- (6E,8Z,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48632, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:65342; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48633; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)- eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49860, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131965; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49861; Evidence=; Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)- eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39759, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76627; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39760; Evidence=; Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)- eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39779, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76634; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39780; Evidence=; Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47212, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:28744, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47213; Evidence=; Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47280, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62845; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47281; Evidence=; Reaction=all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42088, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42089; Evidence=; Reaction=all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42092, Rhea:RHEA- COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42093; Evidence=; Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2- hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47208, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:1156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47209; Evidence=; Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4- hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47292, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87602; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47293; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Cofactor metabolism; retinol metabolism. Lipid metabolism. Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. response to hypoxia liver development lipid hydroxylation catalytic activity monooxygenase activity iron ion binding cytoplasm mitochondrion mitochondrial inner membrane fatty acid metabolic process porphyrin-containing compound metabolic process aging steroid metabolic process estrogen metabolic process cell proliferation arachidonic acid monooxygenase activity steroid hydroxylase activity response to wounding response to virus response to nematode response to herbicide coumarin metabolic process flavonoid metabolic process response to organic substance response to iron(III) ion response to organic cyclic compound oxidoreductase activity oxidoreductase activity, acting on diphenols and related substances as donors oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen flavonoid 3'-monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen insecticide metabolic process drug metabolic process dibenzo-p-dioxin metabolic process dibenzo-p-dioxin catabolic process enzyme binding heme binding Hsp70 protein binding response to food demethylase activity response to lipopolysaccharide developmental process response to vitamin A response to immobilization stress response to drug retinol metabolic process 9-cis-retinoic acid biosynthetic process camera-type eye development intracellular membrane-bounded organelle response to antibiotic response to arsenic-containing substance metal ion binding digestive tract development Hsp90 protein binding response to hyperoxia oxidation-reduction process maternal process involved in parturition hepatocyte differentiation vitamin D 24-hydroxylase activity demethylation cellular response to copper ion cellular response to organic cyclic compound estrogen 16-alpha-hydroxylase activity estrogen 2-hydroxylase activity positive regulation of G1/S transition of mitotic cell cycle uc009pvn.1 uc009pvn.2 uc009pvn.3 uc009pvn.4 uc009pvn.5 
ENSMUST00000216437.2 Or12k5 ENSMUST00000216437.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRY5) ENSMUST00000216437.1 Olfr358 Or12k5 Q7TRY5 Q7TRY5_MOUSE uc008jmh.1 uc008jmh.2 uc008jmh.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008jmh.1 uc008jmh.2 uc008jmh.3 
ENSMUST00000216440.2 Or14j7 ENSMUST00000216440.2 Odorant receptor. (from UniProt Q7TRJ1) ENSMUST00000216440.1 Olfr128 Or14j7 Q7TRJ1 Q7TRJ1_MOUSE uc008cnt.1 uc008cnt.2 uc008cnt.3 Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008cnt.1 uc008cnt.2 uc008cnt.3 
ENSMUST00000216441.2 Gm48743 ENSMUST00000216441.2 Gm48743 (from geneSymbol) ENSMUST00000216441.1 uc287plc.1 uc287plc.2 uc287plc.1 uc287plc.2 
ENSMUST00000216443.3 Or5g9 ENSMUST00000216443.3 Potential odorant receptor. (from UniProt Q8VFK1) ENSMUST00000216443.1 ENSMUST00000216443.2 Mor175-3 OR5G9_MOUSE Olfr1009 Or5g9 Q8VFK1 uc289xpd.1 uc289xpd.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xpd.1 uc289xpd.2 
ENSMUST00000216444.2 Or9s15 ENSMUST00000216444.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFC4) ENSMUST00000216444.1 Olfr1410 Olfr1411 Or9s15 Q8VFC4 Q8VFC4_MOUSE uc287kmh.1 uc287kmh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287kmh.1 uc287kmh.2 
ENSMUST00000216445.2 Or4c121 ENSMUST00000216445.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGM5) ENSMUST00000216445.1 Olfr1226 Or4c121 Q8VGM5 Q8VGM5_MOUSE uc289ybj.1 uc289ybj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ybj.1 uc289ybj.2 
ENSMUST00000216448.3 Gm39325 ENSMUST00000216448.3 Gm39325 (from geneSymbol) AK085078 ENSMUST00000216448.1 ENSMUST00000216448.2 uc292gli.1 uc292gli.2 uc292gli.3 uc292gli.1 uc292gli.2 uc292gli.3 
ENSMUST00000216456.2 Or52ab2 ENSMUST00000216456.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N224) ENSMUST00000216456.1 L7N224 L7N224_MOUSE Olfr597 Or52ab2 uc291tpw.1 uc291tpw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tpw.1 uc291tpw.2 
ENSMUST00000216458.3 Or8g53 ENSMUST00000216458.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFN4) ENSMUST00000216458.1 ENSMUST00000216458.2 Olfr968 Or8g53 Q8VFN4 Q8VFN4_MOUSE uc292gcd.1 uc292gcd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gcd.1 uc292gcd.2 
ENSMUST00000216460.2 Or6c8b ENSMUST00000216460.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRI6) ENSMUST00000216460.1 Olfr765 Or6c8b Q7TRI6 Q7TRI6_MOUSE uc287vwt.1 uc287vwt.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vwt.1 uc287vwt.2 
ENSMUST00000216463.3 Or10g9b ENSMUST00000216463.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VH08) ENSMUST00000216463.1 ENSMUST00000216463.2 Olfr980 Or10g9b Q8VH08 Q8VH08_MOUSE uc009oyy.1 uc009oyy.2 uc009oyy.3 uc009oyy.4 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oyy.1 uc009oyy.2 uc009oyy.3 uc009oyy.4 
ENSMUST00000216465.2 Or2l13 ENSMUST00000216465.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGX2) ENSMUST00000216465.1 Olfr166 Or2l13 Q8VGX2 Q8VGX2_MOUSE uc289dhj.1 uc289dhj.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289dhj.1 uc289dhj.2 
ENSMUST00000216467.2 Gm34006 ENSMUST00000216467.2 Gm34006 (from geneSymbol) AK145144 ENSMUST00000216467.1 uc287qvj.1 uc287qvj.2 uc287qvj.1 uc287qvj.2 
ENSMUST00000216473.2 Or9e1 ENSMUST00000216473.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5NC59) ENSMUST00000216473.1 Olfr311 Olfr312 Or9e1 Q5NC59 Q5NC59_MOUSE uc287ylh.1 uc287ylh.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ylh.1 uc287ylh.2 
ENSMUST00000216475.2 Or4c3d ENSMUST00000216475.2 Odorant receptor. (from UniProt Q60878) ENSMUST00000216475.1 Mor235-1 O4C3D_MOUSE Olfr140 Olfr4 Or4c3d Q60878 Q9R0K1 uc289yer.1 uc289yer.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yer.1 uc289yer.2 
ENSMUST00000216476.2 Or10al7 ENSMUST00000216476.2 olfactory receptor family 10 subfamily AL member 7 (from RefSeq NM_146327.2) ENSMUST00000216476.1 G3UXX8 NM_146327 Olfr129 Or10al7 Q7TRI9 Q7TRI9_MOUSE uc029thr.1 uc029thr.2 uc029thr.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB173020.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849383, SAMN01164131 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: experimental evidence (PMID:11802173) RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc029thr.1 uc029thr.2 uc029thr.3 
ENSMUST00000216477.2 Gm34184 ENSMUST00000216477.2 predicted gene, 34184 (from RefSeq NR_152790.1) ENSMUST00000216477.1 NR_152790 uc287tqt.1 uc287tqt.2 uc287tqt.1 uc287tqt.2 
ENSMUST00000216487.2 Gm49367 ENSMUST00000216487.2 Gm49367 (from geneSymbol) AK144443 ENSMUST00000216487.1 uc292fsh.1 uc292fsh.2 uc292fsh.1 uc292fsh.2 
ENSMUST00000216488.2 Or2h2 ENSMUST00000216488.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q0VEL5) ENSMUST00000216488.1 Olfr90 Or2h2 Q0VEL5 Q0VEL5_MOUSE uc289kxp.1 uc289kxp.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kxp.1 uc289kxp.2 
ENSMUST00000216489.2 Or5p63 ENSMUST00000216489.2 Membrane ; Multi- pass membrane protein (from UniProt Q7TRU9) ENSMUST00000216489.1 Olfr487 Or5p63 Q7TRU9 Q7TRU9_MOUSE uc291ugj.1 uc291ugj.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ugj.1 uc291ugj.2 
ENSMUST00000216490.2 Gm48135 ENSMUST00000216490.2 Gm48135 (from geneSymbol) ENSMUST00000216490.1 uc292gvi.1 uc292gvi.2 uc292gvi.1 uc292gvi.2 
ENSMUST00000216495.3 Or5h22 ENSMUST00000216495.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N5T5) ENSMUST00000216495.1 ENSMUST00000216495.2 K7N5T5 K7N5T5_MOUSE Olfr190 Or5h22 uc289fgb.1 uc289fgb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289fgb.1 uc289fgb.2 
ENSMUST00000216496.2 Or8b47 ENSMUST00000216496.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A140T8K0) A0A140T8K0 A0A140T8K0_MOUSE ENSMUST00000216496.1 Olfr911 Or8b47 uc292fyk.1 uc292fyk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fyk.1 uc292fyk.2 
ENSMUST00000216500.2 Or10a49 ENSMUST00000216500.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRU4) ENSMUST00000216500.1 Olfr517 Or10a49 Q7TRU4 Q7TRU4_MOUSE uc009jcy.1 uc009jcy.2 uc009jcy.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jcy.1 uc009jcy.2 uc009jcy.3 
ENSMUST00000216502.3 Or8b42 ENSMUST00000216502.3 Membrane ; Multi- pass membrane protein (from UniProt Q7TRD1) ENSMUST00000216502.1 ENSMUST00000216502.2 Olfr901 Or8b42 Q7TRD1 Q7TRD1_MOUSE uc292fxz.1 uc292fxz.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fxz.1 uc292fxz.2 
ENSMUST00000216503.2 Gm47858 ENSMUST00000216503.2 Gm47858 (from geneSymbol) ENSMUST00000216503.1 uc292fow.1 uc292fow.2 uc292fow.1 uc292fow.2 
ENSMUST00000216506.2 Or5a3 ENSMUST00000216506.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFV3) ENSMUST00000216506.1 Olfr1441 Or5a3 Q8VFV3 Q8VFV3_MOUSE uc008gtz.1 uc008gtz.2 uc008gtz.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gtz.1 uc008gtz.2 uc008gtz.3 
ENSMUST00000216508.2 Hinfp ENSMUST00000216508.2 histone H4 transcription factor, transcript variant 1 (from RefSeq NM_172162.4) E9QPQ4 ENSMUST00000216508.1 HINFP_MOUSE Mizf NM_172162 Q8BWY0 Q8K1K9 uc009pcr.1 uc009pcr.2 uc009pcr.3 uc009pcr.4 Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. Binds MBD2 and a histone deacetylase complex. Interacts with NPAT (By similarity). Nucleus Note=Associated with discrete nuclear foci. Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation (By similarity). DNA damage checkpoint G1/S transition of mitotic cell cycle regulation of transcription involved in G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity nucleus nucleoplasm DNA repair transcription, DNA-templated regulation of transcription, DNA-templated regulation of gene expression positive regulation of gene expression negative regulation of gene expression Cajal body enzyme binding histone binding transcription regulatory region DNA binding establishment of protein localization myoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated metal ion binding nucleolus uc009pcr.1 uc009pcr.2 uc009pcr.3 uc009pcr.4 
ENSMUST00000216516.2 Or52z12 ENSMUST00000216516.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGA1) ENSMUST00000216516.1 Olfr617 Or52z12 Q8VGA1 Q8VGA1_MOUSE uc291tqz.1 uc291tqz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tqz.1 uc291tqz.2 
ENSMUST00000216518.2 Gm47856 ENSMUST00000216518.2 Gm47856 (from geneSymbol) AK037139 ENSMUST00000216518.1 uc056ygr.1 uc056ygr.2 uc056ygr.1 uc056ygr.2 
ENSMUST00000216519.2 Or5ac15 ENSMUST00000216519.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N1Y8) ENSMUST00000216519.1 L7N1Y8 L7N1Y8_MOUSE Olfr194 Or5ac15 uc289fgi.1 uc289fgi.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289fgi.1 uc289fgi.2 
ENSMUST00000216522.2 Gm47197 ENSMUST00000216522.2 Gm47197 (from geneSymbol) ENSMUST00000216522.1 uc292hak.1 uc292hak.2 uc292hak.1 uc292hak.2 
ENSMUST00000216523.2 Or2y3 ENSMUST00000216523.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGC8) ENSMUST00000216523.1 Olfr131 Or2y3 Q8VGC8 Q8VGC8_MOUSE uc289lbn.1 uc289lbn.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lbn.1 uc289lbn.2 
ENSMUST00000216524.2 Or51r1 ENSMUST00000216524.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q544) E9Q544 E9Q544_MOUSE ENSMUST00000216524.1 Olfr550 Or51r1 uc291tnb.1 uc291tnb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tnb.1 uc291tnb.2 
ENSMUST00000216525.3 Gm35177 ENSMUST00000216525.3 Gm35177 (from geneSymbol) ENSMUST00000216525.1 ENSMUST00000216525.2 uc292ged.1 uc292ged.2 uc292ged.3 uc292ged.1 uc292ged.2 uc292ged.3 
ENSMUST00000216530.2 Or9k2 ENSMUST00000216530.2 Odorant receptor. (from UniProt Q8VFU7) ENSMUST00000216530.1 Olfr825 Or9k2 Q8VFU7 Q8VFU7_MOUSE uc007hrf.1 uc007hrf.2 uc007hrf.3 Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hrf.1 uc007hrf.2 uc007hrf.3 
ENSMUST00000216531.2 1700019J19Rik ENSMUST00000216531.2 1700019J19Rik (from geneSymbol) AK006126 ENSMUST00000216531.1 uc292emj.1 uc292emj.2 uc292emj.1 uc292emj.2 
ENSMUST00000216533.2 Gm47475 ENSMUST00000216533.2 Gm47475 (from geneSymbol) ENSMUST00000216533.1 uc292gjy.1 uc292gjy.2 uc292gjy.1 uc292gjy.2 
ENSMUST00000216538.2 Or7d11 ENSMUST00000216538.2 Possible olfactory or taste receptor. (from UniProt Q7TRF3) ENSMUST00000216538.1 O7D11_MOUSE Olfr867 Or7d11 Q7TRF3 uc292euz.1 uc292euz.2 Possible olfactory or taste receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292euz.1 uc292euz.2 
ENSMUST00000216547.2 Or8k23 ENSMUST00000216547.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AVY0) A2AVY0 A2AVY0_MOUSE ENSMUST00000216547.1 Olfr1056 Or8k23 uc289xru.1 uc289xru.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xru.1 uc289xru.2 
ENSMUST00000216555.2 Gm38661 ENSMUST00000216555.2 Gm38661 (from geneSymbol) ENSMUST00000216555.1 uc292mie.1 uc292mie.2 uc292mie.1 uc292mie.2 
ENSMUST00000216561.2 Or4c125 ENSMUST00000216561.2 olfactory receptor family 4 subfamily C member 125 (from RefSeq NM_146972.2) ENSMUST00000216561.1 NM_146972 Olfr1233 Or4c125 Q8VGN0 Q8VGN0_MOUSE uc289ycc.1 uc289ycc.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB173194.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ycc.1 uc289ycc.2 
ENSMUST00000216562.3 Or2a20 ENSMUST00000216562.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF17) ENSMUST00000216562.1 ENSMUST00000216562.2 Olfr434 Or2a20 Q8VF17 Q8VF17_MOUSE uc009bsk.1 uc009bsk.2 uc009bsk.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009bsk.1 uc009bsk.2 uc009bsk.3 
ENSMUST00000216565.2 Gm35288 ENSMUST00000216565.2 predicted gene, 35288 (from RefSeq NR_188924.1) ENSMUST00000216565.1 NR_188924 uc292hzb.1 uc292hzb.2 uc292hzb.1 uc292hzb.2 
ENSMUST00000216566.3 Or5al5 ENSMUST00000216566.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2ARY0) A2ARY0 A2ARY0_MOUSE ENSMUST00000216566.1 ENSMUST00000216566.2 Olfr1039 Olfr1040 Or5al5 uc289xqt.1 uc289xqt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xqt.1 uc289xqt.2 
ENSMUST00000216569.3 Gm47564 ENSMUST00000216569.3 Gm47564 (from geneSymbol) ENSMUST00000216569.1 ENSMUST00000216569.2 uc292emo.1 uc292emo.2 uc292emo.3 uc292emo.1 uc292emo.2 uc292emo.3 
ENSMUST00000216570.2 Or52a33 ENSMUST00000216570.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGY7) ENSMUST00000216570.1 Olfr622 Or52a33 Q8VGY7 Q8VGY7_MOUSE uc291tri.1 uc291tri.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tri.1 uc291tri.2 
ENSMUST00000216581.2 Or52s1b ENSMUST00000216581.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRR7) ENSMUST00000216581.1 Olfr591 Or52s1b Q7TRR7 Q7TRR7_MOUSE uc291tpm.1 uc291tpm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tpm.1 uc291tpm.2 
ENSMUST00000216587.2 Or4a81 ENSMUST00000216587.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFB1) ENSMUST00000216587.1 Olfr1254 Or4a81 Q8VFB1 Q8VFB1_MOUSE uc289ydm.1 uc289ydm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ydm.1 uc289ydm.2 
ENSMUST00000216589.2 Or10ak9 ENSMUST00000216589.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BRQ0) A0A2I3BRQ0 A0A2I3BRQ0_MOUSE ENSMUST00000216589.1 Olfr1331 Or10ak9 uc290piw.1 uc290piw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc290piw.1 uc290piw.2 
ENSMUST00000216590.2 Phxr4 ENSMUST00000216590.2 per-hexamer repeat gene 4 (from RefSeq NR_028271.1) ENSMUST00000216590.1 NR_028271 uc009odu.1 uc009odu.2 uc009odu.3 uc009odu.4 uc009odu.1 uc009odu.2 uc009odu.3 uc009odu.4 
ENSMUST00000216594.2 Tipin ENSMUST00000216594.2 timeless interacting protein, transcript variant 5 (from RefSeq NR_136926.1) ENSMUST00000216594.1 NR_136926 Q91WA1 Q9CQM3 Q9D1J4 TIPIN_MOUSE uc009qbt.1 uc009qbt.2 uc009qbt.3 uc009qbt.4 The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. [provided by RefSeq, Feb 2014]. Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Interacts with MCM6 and MCM7 (By similarity). Interacts with TIMELESS (via N-terminus), which impairs TIMELESS self-association. Interacts with RPA2 and PRDX2. Cytoplasm Nucleus Expressed in brain. Expression peaks between 11 dpc and 15 dpc. At 7.5 dpc, expressed in germ cell layers. At 14.5 dpc, expressed at highest levels in thymus, liver, gastrointestinal tract, lung and the rapidly proliferating ventricular zone of the brain. Belongs to the CSM3 family. DNA replication checkpoint DNA damage checkpoint nuclear chromatin DNA binding protein binding nucleus cytoplasm cellular response to DNA damage stimulus cell cycle positive regulation of cell proliferation response to UV replication fork protection complex intra-S DNA damage checkpoint replication fork arrest intracellular membrane-bounded organelle cell cycle phase transition replication fork protection cell division uc009qbt.1 uc009qbt.2 uc009qbt.3 uc009qbt.4 
ENSMUST00000216603.2 Or10j3 ENSMUST00000216603.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PWV2) E9PWV2 E9PWV2_MOUSE ENSMUST00000216603.1 Olfr218 Or10j3 uc287nzw.1 uc287nzw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287nzw.1 uc287nzw.2 
ENSMUST00000216608.2 Or1e34 ENSMUST00000216608.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGR5) ENSMUST00000216608.1 Olfr394 Or1e34 Q8VGR5 Q8VGR5_MOUSE uc288aaj.1 uc288aaj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288aaj.1 uc288aaj.2 
ENSMUST00000216609.2 Gm49338 ENSMUST00000216609.2 Gm49338 (from geneSymbol) AK077428 ENSMUST00000216609.1 uc292gwg.1 uc292gwg.2 uc292gwg.1 uc292gwg.2 
ENSMUST00000216612.3 Or52h1 ENSMUST00000216612.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG19) ENSMUST00000216612.1 ENSMUST00000216612.2 F6VL06 Olfr648 Or52h1 Q8VG19 Q8VG19_MOUSE uc291ttb.1 uc291ttb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ttb.1 uc291ttb.2 
ENSMUST00000216615.2 Gm48627 ENSMUST00000216615.2 Gm48627 (from geneSymbol) AK140297 ENSMUST00000216615.1 uc292ffe.1 uc292ffe.2 uc292ffe.1 uc292ffe.2 
ENSMUST00000216616.3 Or4c3 ENSMUST00000216616.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9R0K2) ENSMUST00000216616.1 ENSMUST00000216616.2 MOR18 Olfr1264 Or4c3 Q9R0K2 Q9R0K2_MOUSE uc289yeo.1 uc289yeo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yeo.1 uc289yeo.2 
ENSMUST00000216633.2 Or10h1b ENSMUST00000216633.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N6Q1) ENSMUST00000216633.1 K7N6Q1 K7N6Q1_MOUSE Olfr55 Or10h1b uc289jtu.1 uc289jtu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289jtu.1 uc289jtu.2 
ENSMUST00000216634.2 Or4q3 ENSMUST00000216634.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A286YCU8) A0A286YCU8 A0A286YCU8_MOUSE ENSMUST00000216634.1 Olfr735 Or4q3 uc288tlf.1 uc288tlf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tlf.1 uc288tlf.2 
ENSMUST00000216637.2 Or4k77 ENSMUST00000216637.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQY4) ENSMUST00000216637.1 Olfr1280 Olfr1283 Olfr1285 Or4k77 Q7TQY4 Q7TQY4_MOUSE uc289zeq.1 uc289zeq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zeq.1 uc289zeq.2 
ENSMUST00000216641.2 Or2y1d ENSMUST00000216641.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGX0) ENSMUST00000216641.1 Olfr1389 Or2y1d Q8VGX0 Q8VGX0_MOUSE uc287xtt.1 uc287xtt.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xtt.1 uc287xtt.2 
ENSMUST00000216645.2 Or1j11 ENSMUST00000216645.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGK8) ENSMUST00000216645.1 Olfr339 Olfr350 Or1j11 Q8VGK8 Q8VGK8_MOUSE uc289voz.1 uc289voz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289voz.1 uc289voz.2 
ENSMUST00000216646.2 4930584E12Rik ENSMUST00000216646.2 4930584E12Rik (from geneSymbol) AK016348 ENSMUST00000216646.1 uc292enp.1 uc292enp.2 uc292enp.1 uc292enp.2 
ENSMUST00000216647.2 Or10d5 ENSMUST00000216647.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG91) ENSMUST00000216647.1 Olfr975 Or10d5 Q8VG91 Q8VG91_MOUSE uc292gco.1 uc292gco.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gco.1 uc292gco.2 
ENSMUST00000216650.2 Or2r11 ENSMUST00000216650.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF80) ENSMUST00000216650.1 Olfr458 Or2r11 Q8VF80 Q8VF80_MOUSE uc291dye.1 uc291dye.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dye.1 uc291dye.2 
ENSMUST00000216654.2 Gm4922 ENSMUST00000216654.2 predicted gene 4922 (from RefSeq NM_177706.4) ENSMUST00000216654.1 NM_177706 Q8C0N0 SMKZ_MOUSE uc007emq.1 uc007emq.2 uc007emq.3 May play a role in sperm motility, especially in the regulation of flagellar function. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity intracellular signal transduction uc007emq.1 uc007emq.2 uc007emq.3 
ENSMUST00000216659.2 Or9i14 ENSMUST00000216659.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG65) ENSMUST00000216659.1 Olfr1499 Or9i14 Q8VG65 Q8VG65_MOUSE uc008gwb.1 uc008gwb.2 uc008gwb.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gwb.1 uc008gwb.2 uc008gwb.3 
ENSMUST00000216661.2 Or9k2b ENSMUST00000216661.2 Odorant receptor. (from UniProt Q8VFU6) ENSMUST00000216661.1 Olfr825 Olfr826 Or9k2b Q8VFU6 Q8VFU6_MOUSE uc287was.1 uc287was.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287was.1 uc287was.2 
ENSMUST00000216665.3 Or8u3-ps ENSMUST00000216665.3 Or8u3-ps (from geneSymbol) ENSMUST00000216665.1 ENSMUST00000216665.2 uc289xqq.1 uc289xqq.2 uc289xqq.1 uc289xqq.2 
ENSMUST00000216675.2 Or4p22 ENSMUST00000216675.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG86) ENSMUST00000216675.1 Olfr1184 Or4p22 Q8VG86 Q8VG86_MOUSE uc289xyl.1 uc289xyl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xyl.1 uc289xyl.2 
ENSMUST00000216687.3 Gm47328 ENSMUST00000216687.3 Gm47328 (from geneSymbol) ENSMUST00000216687.1 ENSMUST00000216687.2 uc292kfi.1 uc292kfi.2 uc292kfi.3 uc292kfi.1 uc292kfi.2 uc292kfi.3 
ENSMUST00000216692.2 Gm49337 ENSMUST00000216692.2 Belongs to the PI3K p85 subunit family. (from UniProt A0A1L1ST33) A0A1L1ST33 A0A1L1ST33_MOUSE AK163413 ENSMUST00000216692.1 Gm49337 uc290oxy.1 uc290oxy.2 Belongs to the PI3K p85 subunit family. phosphatidylinositol 3-kinase complex insulin receptor signaling pathway regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity uc290oxy.1 uc290oxy.2 
ENSMUST00000216695.3 Gm31408 ENSMUST00000216695.3 Gm31408 (from geneSymbol) ENSMUST00000216695.1 ENSMUST00000216695.2 uc292fmy.1 uc292fmy.2 uc292fmy.3 uc292fmy.1 uc292fmy.2 uc292fmy.3 
ENSMUST00000216696.3 Gm47960 ENSMUST00000216696.3 Gm47960 (from geneSymbol) ENSMUST00000216696.1 ENSMUST00000216696.2 uc292hgm.1 uc292hgm.2 uc292hgm.3 uc292hgm.1 uc292hgm.2 uc292hgm.3 
ENSMUST00000216701.3 Gm47512 ENSMUST00000216701.3 Gm47512 (from geneSymbol) AK038624 ENSMUST00000216701.1 ENSMUST00000216701.2 uc287qmd.1 uc287qmd.2 uc287qmd.3 uc287qmd.1 uc287qmd.2 uc287qmd.3 
ENSMUST00000216702.2 Parp16 ENSMUST00000216702.2 Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes. Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading. Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2. Involved in the unfolded protein response (UPR) by ADP- ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases. (from UniProt Q7TMM8) AK033791 Artd15 ENSMUST00000216702.1 PAR16_MOUSE Parp16 Q3V031 Q7TMM8 Q8CC71 uc292iek.1 uc292iek.2 Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes. Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading. Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2. Involved in the unfolded protein response (UPR) by ADP- ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases. Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA- COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=; Reaction=L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L- lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58220, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:15088, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:142515; Evidence=; Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA- COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence=; In absence of activation signal, PARP16 is autoinhibited by the PARP alpha-helical domain (also named HD region), which prevents effective NAD(+)-binding. Activity is highly stimulated by signals, which unfold the PARP alpha-helical domain, relieving autoinhibition. Interacts with KPNB1. Endoplasmic reticulum membrane ; Single-pass type IV membrane protein The PARP alpha-helical domain (also named HD region) is regulatory, it packs against the catalytic domain. Auto-mono-ADP-ribosylated. Belongs to the ARTD/PARP family. NAD+ ADP-ribosyltransferase activity nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane protein ADP-ribosylation response to unfolded protein membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups kinase binding endoplasmic reticulum unfolded protein response IRE1-mediated unfolded protein response protein serine/threonine kinase activator activity negative regulation of cell death protein auto-ADP-ribosylation endoplasmic reticulum tubular network positive regulation of protein serine/threonine kinase activity protein ADP-ribosylase activity cellular response to leukemia inhibitory factor uc292iek.1 uc292iek.2 
ENSMUST00000216704.2 Gm47640 ENSMUST00000216704.2 Gm47640 (from geneSymbol) ENSMUST00000216704.1 uc292fum.1 uc292fum.2 uc292fum.1 uc292fum.2 
ENSMUST00000216706.3 Or12k7 ENSMUST00000216706.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFP3) ENSMUST00000216706.1 ENSMUST00000216706.2 Olfr360 Or12k7 Q8VFP3 Q8VFP3_MOUSE uc289vqf.1 uc289vqf.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vqf.1 uc289vqf.2 
ENSMUST00000216713.2 Or5d3 ENSMUST00000216713.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BPX0) A0A2I3BPX0 A0A2I3BPX0_MOUSE ENSMUST00000216713.1 Olfr1177 Olfr1177-ps Or5d3 uc289xxz.1 uc289xxz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxz.1 uc289xxz.2 
ENSMUST00000216719.2 Or2k2 ENSMUST00000216719.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AM35) A2AM35 A2AM35_MOUSE ENSMUST00000216719.1 Olfr267 Or2k2 uc008szd.1 uc008szd.2 uc008szd.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008szd.1 uc008szd.2 uc008szd.3 
ENSMUST00000216722.2 Or3a1c ENSMUST00000216722.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFX8) ENSMUST00000216722.1 Olfr402 Or3a1c Q8VFX8 Q8VFX8_MOUSE uc007kbn.1 uc007kbn.2 uc007kbn.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007kbn.1 uc007kbn.2 uc007kbn.3 
ENSMUST00000216724.3 Or8b1b ENSMUST00000216724.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRC9) ENSMUST00000216724.1 ENSMUST00000216724.2 Olfr904 Or8b1b Q7TRC9 Q7TRC9_MOUSE uc292fyd.1 uc292fyd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fyd.1 uc292fyd.2 
ENSMUST00000216725.2 Or2t47 ENSMUST00000216725.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5NCD3) ENSMUST00000216725.1 Olfr328 Or2t47 Q5NCD3 Q5NCD3_MOUSE uc287yjz.1 uc287yjz.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287yjz.1 uc287yjz.2 
ENSMUST00000216727.2 Or12j3 ENSMUST00000216727.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFE8) ENSMUST00000216727.1 Olfr530 Or12j3 Q8VFE8 Q8VFE8_MOUSE uc009khp.1 uc009khp.2 uc009khp.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009khp.1 uc009khp.2 uc009khp.3 
ENSMUST00000216728.2 Gm47326 ENSMUST00000216728.2 Gm47326 (from geneSymbol) ENSMUST00000216728.1 uc292emx.1 uc292emx.2 uc292emx.1 uc292emx.2 
ENSMUST00000216737.3 Gm19531 ENSMUST00000216737.3 Gm19531 (from geneSymbol) AK134928 ENSMUST00000216737.1 ENSMUST00000216737.2 uc009qrz.1 uc009qrz.2 uc009qrz.3 uc009qrz.1 uc009qrz.2 uc009qrz.3 
ENSMUST00000216742.2 ENSMUSG00000121677 ENSMUST00000216742.2 ENSMUSG00000121677 (from geneSymbol) ENSMUST00000216742.1 LF204953 uc287qzf.1 uc287qzf.2 uc287qzf.1 uc287qzf.2 
ENSMUST00000216752.3 Gm48215 ENSMUST00000216752.3 Gm48215 (from geneSymbol) ENSMUST00000216752.1 ENSMUST00000216752.2 uc287qhv.1 uc287qhv.2 uc287qhv.3 uc287qhv.1 uc287qhv.2 uc287qhv.3 
ENSMUST00000216753.3 Or1j21 ENSMUST00000216753.3 Odorant receptor. Activated by (+) and (-)-carvone. (from UniProt Q8VGK5) ENSMUST00000216753.1 ENSMUST00000216753.2 Mor136-6 O1J21_MOUSE Olfr50 Or1j21 Q8VGK5 Q9Z1U9 uc289vpl.1 uc289vpl.2 Odorant receptor. Activated by (+) and (-)-carvone. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane isoprenoid binding response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vpl.1 uc289vpl.2 
ENSMUST00000216754.3 Or1m1 ENSMUST00000216754.3 Odorant receptor. (from UniProt Q8VFM9) ENSMUST00000216754.1 ENSMUST00000216754.2 Mor132-1 OR1M1_MOUSE Olfr24 Or1m1 Q62340 Q8VFM9 uc009ogw.1 uc009ogw.2 uc009ogw.3 Odorant receptor. Cell membrane ; Multi-pass membrane protein Expressed in testis. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ogw.1 uc009ogw.2 uc009ogw.3 
ENSMUST00000216758.2 Or2t43 ENSMUST00000216758.2 olfactory receptor family 2 subfamily T member 43 (from RefSeq NM_207695.2) ENSMUST00000216758.1 M9MMJ7 M9MMJ7_MOUSE NM_207695 Olfr224 Or2t43 uc287ykd.1 uc287ykd.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ykd.1 uc287ykd.2 
ENSMUST00000216762.2 Or4a2 ENSMUST00000216762.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGM8) ENSMUST00000216762.1 Olfr1239 Or4a2 Q8VGM8 Q8VGM8_MOUSE uc289ycl.1 uc289ycl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ycl.1 uc289ycl.2 
ENSMUST00000216767.2 Or4s2b ENSMUST00000216767.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1SQ65) A0A1L1SQ65 A0A1L1SQ65_MOUSE ENSMUST00000216767.1 Olfr1193 Or4s2b uc289xza.1 uc289xza.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xza.1 uc289xza.2 
ENSMUST00000216772.2 Or12e1 ENSMUST00000216772.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2ATA0) A2ATA0 A2ATA0_MOUSE ENSMUST00000216772.1 Olfr1112 Or12e1 uc289xuf.1 uc289xuf.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xuf.1 uc289xuf.2 
ENSMUST00000216776.2 Or52m2 ENSMUST00000216776.2 Membrane ; Multi- pass membrane protein (from UniProt Q7TRS6) ENSMUST00000216776.1 Olfr553 Or52m2 Q7TRS6 Q7TRS6_MOUSE uc291tne.1 uc291tne.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tne.1 uc291tne.2 
ENSMUST00000216779.3 4933411E02Rik ENSMUST00000216779.3 4933411E02Rik (from geneSymbol) AK016767 ENSMUST00000216779.1 ENSMUST00000216779.2 uc292lwe.1 uc292lwe.2 uc292lwe.3 uc292lwe.1 uc292lwe.2 uc292lwe.3 
ENSMUST00000216780.2 Gm39307 ENSMUST00000216780.2 predicted gene, 39307 (from RefSeq NR_166680.1) ENSMUST00000216780.1 NR_166680 uc009ooi.1 uc009ooi.2 uc009ooi.3 uc009ooi.1 uc009ooi.2 uc009ooi.3 
ENSMUST00000216787.2 Gm47389 ENSMUST00000216787.2 Gm47389 (from geneSymbol) AK136081 ENSMUST00000216787.1 uc287qyd.1 uc287qyd.2 uc287qyd.1 uc287qyd.2 
ENSMUST00000216801.3 Or10n1 ENSMUST00000216801.3 Odorant receptor. (from UniProt Q60887) ENSMUST00000216801.1 ENSMUST00000216801.2 Mor224-4 O10N1_MOUSE Olfr148 Olfr7 Or10n1 Q60887 Q9EQ88 uc009oyg.1 uc009oyg.2 uc009oyg.3 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oyg.1 uc009oyg.2 uc009oyg.3 
ENSMUST00000216804.2 Or2h15 ENSMUST00000216804.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRI8) ENSMUST00000216804.1 Olfr132 Or2h15 Q7TRI8 Q7TRI8_MOUSE uc289lbq.1 uc289lbq.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lbq.1 uc289lbq.2 
ENSMUST00000216805.3 Or5b96 ENSMUST00000216805.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFX4) ENSMUST00000216805.1 ENSMUST00000216805.2 Olfr1446 Or5b96 Q8VFX4 Q8VFX4_MOUSE uc008gut.1 uc008gut.2 uc008gut.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gut.1 uc008gut.2 uc008gut.3 
ENSMUST00000216807.2 Or5m8 ENSMUST00000216807.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR87) ENSMUST00000216807.1 Olfr1031 Or5m8 Q7TR87 Q7TR87_MOUSE uc289xqe.1 uc289xqe.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xqe.1 uc289xqe.2 
ENSMUST00000216811.2 Or52a5 ENSMUST00000216811.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PYY2) E9PYY2 E9PYY2_MOUSE ENSMUST00000216811.1 Olfr68 Olfr69 Or52a5 uc291tru.1 uc291tru.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tru.1 uc291tru.2 
ENSMUST00000216822.2 Or11m3 ENSMUST00000216822.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFD8) ENSMUST00000216822.1 Olfr234 Olfr279 Or11m3 Q8VFD8 Q8VFD8_MOUSE uc289bax.1 uc289bax.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289bax.1 uc289bax.2 
ENSMUST00000216827.2 Gm20745 ENSMUST00000216827.2 predicted gene, 20745 (from RefSeq NR_045745.1) ENSMUST00000216827.1 NR_045745 uc029xeh.1 uc029xeh.2 uc029xeh.1 uc029xeh.2 
ENSMUST00000216831.3 Or9g10 ENSMUST00000216831.3 olfactory receptor family 9 subfamily G member 10, transcript variant 1, non-coding (from RefSeq NR_160648.1) ENSMUST00000216831.1 ENSMUST00000216831.2 NR_160648 uc289xpf.1 uc289xpf.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. uc289xpf.1 uc289xpf.2 
ENSMUST00000216834.2 Or5ac19 ENSMUST00000216834.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TS38) ENSMUST00000216834.1 Olfr201 Or5ac19 Q7TS38 Q7TS38_MOUSE uc289fgp.1 uc289fgp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289fgp.1 uc289fgp.2 
ENSMUST00000216835.2 Or9i1b ENSMUST00000216835.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQQ2) ENSMUST00000216835.1 Olfr1505 Or9i1b Q7TQQ2 Q7TQQ2_MOUSE uc289rhk.1 uc289rhk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rhk.1 uc289rhk.2 
ENSMUST00000216839.3 Or7g29 ENSMUST00000216839.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFF4) ENSMUST00000216839.1 ENSMUST00000216839.2 Olfr847 Or7g29 Q8VFF4 Q8VFF4_MOUSE uc292ett.1 uc292ett.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292ett.1 uc292ett.2 
ENSMUST00000216851.2 Or8k37 ENSMUST00000216851.2 olfactory receptor family 8 subfamily K member 37 (from RefSeq NM_207135.2) A0A1L1STZ9 A0A1L1STZ9_MOUSE ENSMUST00000216851.1 NM_207135 Olfr1084 Or8k37 uc008kmr.1 uc008kmr.2 uc008kmr.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kmr.1 uc008kmr.2 uc008kmr.3 
ENSMUST00000216860.2 Gm57856 ENSMUST00000216860.2 Gm57856 (from geneSymbol) AK020119 ENSMUST00000216860.1 uc292ghv.1 uc292ghv.2 uc292ghv.1 uc292ghv.2 
ENSMUST00000216868.2 Or2ag13 ENSMUST00000216868.2 olfactory receptor family 2 subfamily AG member 13 (from RefSeq NM_146598.2) ENSMUST00000216868.1 NM_146598 Olfr695 Or2ag13 Q8VFM3 Q8VFM3_MOUSE uc009izy.1 uc009izy.2 uc009izy.3 uc009izy.4 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## CDS exon combination :: BC104092.1, CB173337.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMN01164131 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009izy.1 uc009izy.2 uc009izy.3 uc009izy.4 
ENSMUST00000216871.3 Or2d36 ENSMUST00000216871.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EPG6) ENSMUST00000216871.1 ENSMUST00000216871.2 Olfr716 Or2d36 Q9EPG6 Q9EPG6_MOUSE uc291uel.1 uc291uel.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uel.1 uc291uel.2 
ENSMUST00000216879.2 Or6c69c ENSMUST00000216879.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFU1) ENSMUST00000216879.1 Olfr822 Or6c69c Q8VFU1 Q8VFU1_MOUSE uc007hrc.1 uc007hrc.2 uc007hrc.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hrc.1 uc007hrc.2 uc007hrc.3 
ENSMUST00000216882.2 Or1j18 ENSMUST00000216882.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGK2) ENSMUST00000216882.1 Olfr347 Or1j18 Q8VGK2 Q8VGK2_MOUSE uc008jlv.1 uc008jlv.2 uc008jlv.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008jlv.1 uc008jlv.2 uc008jlv.3 
ENSMUST00000216890.2 Gm47253 ENSMUST00000216890.2 Gm47253 (from geneSymbol) ENSMUST00000216890.1 uc287tqw.1 uc287tqw.2 uc287tqw.1 uc287tqw.2 
ENSMUST00000216894.2 Gm39383 ENSMUST00000216894.2 Gm39383 (from geneSymbol) ENSMUST00000216894.1 uc292jey.1 uc292jey.2 uc292jey.1 uc292jey.2 
ENSMUST00000216896.2 Gm32335 ENSMUST00000216896.2 Gm32335 (from geneSymbol) AK141974 ENSMUST00000216896.1 uc292hbm.1 uc292hbm.2 uc292hbm.1 uc292hbm.2 
ENSMUST00000216899.2 Gm47676 ENSMUST00000216899.2 Gm47676 (from geneSymbol) ENSMUST00000216899.1 uc292hwp.1 uc292hwp.2 uc292hwp.1 uc292hwp.2 
ENSMUST00000216901.2 Or8s16 ENSMUST00000216901.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TS17) ENSMUST00000216901.1 Olfr285 Or8s16 Q7TS17 Q7TS17_MOUSE uc289bag.1 uc289bag.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289bag.1 uc289bag.2 
ENSMUST00000216902.2 Gm48714 ENSMUST00000216902.2 Gm48714 (from geneSymbol) ENSMUST00000216902.1 uc287pvv.1 uc287pvv.2 uc287pvv.1 uc287pvv.2 
ENSMUST00000216904.2 Or52h9 ENSMUST00000216904.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG78) ENSMUST00000216904.1 Olfr651 Or52h9 Q8VG78 Q8VG78_MOUSE uc291tue.1 uc291tue.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tue.1 uc291tue.2 
ENSMUST00000216906.2 Or6c2b ENSMUST00000216906.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8K501) ENSMUST00000216906.1 Olfr769 Or6c2b Q8K501 Q8K501_MOUSE uc287vwy.1 uc287vwy.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vwy.1 uc287vwy.2 
ENSMUST00000216910.3 Or5b3 ENSMUST00000216910.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFW5) ENSMUST00000216910.1 ENSMUST00000216910.2 Olfr1469 Or5b3 Q8VFW5 Q8VFW5_MOUSE uc289rew.1 uc289rew.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rew.1 uc289rew.2 
ENSMUST00000216912.2 Or8g22 ENSMUST00000216912.2 olfactory receptor 936 (from RefSeq NM_207139.1) ENSMUST00000216912.1 NM_207139 uc292fzz.1 uc292fzz.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Feb 2010]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## uc292fzz.1 uc292fzz.2 
ENSMUST00000216917.2 Gm47079 ENSMUST00000216917.2 Gm47079 (from geneSymbol) AK140086 ENSMUST00000216917.1 uc292eyx.1 uc292eyx.2 uc292eyx.1 uc292eyx.2 
ENSMUST00000216918.2 Gm33858 ENSMUST00000216918.2 Gm33858 (from geneSymbol) ENSMUST00000216918.1 uc292mek.1 uc292mek.2 uc292mek.1 uc292mek.2 
ENSMUST00000216919.2 Or5p76 ENSMUST00000216919.2 Potential odorant receptor. (from UniProt Q8VG09) ENSMUST00000216919.1 Mor204-8 O5P76_MOUSE Olfr502 Or5p76 Q0VBE2 Q8VG09 uc009jcm.1 uc009jcm.2 uc009jcm.3 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jcm.1 uc009jcm.2 uc009jcm.3 
ENSMUST00000216922.2 9230106D20Rik ENSMUST00000216922.2 9230106D20Rik (from geneSymbol) AK033775 ENSMUST00000216922.1 uc287pvr.1 uc287pvr.2 uc287pvr.1 uc287pvr.2 
ENSMUST00000216925.2 Ubl7 ENSMUST00000216925.2 ubiquitin-like 7 (bone marrow stromal cell-derived), transcript variant 2 (from RefSeq NM_027086.4) E9Q1S0 ENSMUST00000216925.1 NM_027086 Q91W67 Q9D7P5 UBL7_MOUSE uc009pvx.1 uc009pvx.2 uc009pvx.3 uc009pvx.4 Interferon-stimulated protein that positively regulates RNA virus-triggered innate immune signaling. Mechanistically, promotes 'Lys-27'-linked polyubiquitination of MAVS through TRIM21 leading to enhanced the IFN signaling pathway. Binds ubiquitin. Interacts with MAVS; this interaction enhances TRIM21-dependent 'Lys-27'-linked polyubiquitination of MAVS. Deubiquitinated by OTUD4 which stabilizes UBL7 expression. cytosol ubiquitin-dependent protein catabolic process polyubiquitin binding uc009pvx.1 uc009pvx.2 uc009pvx.3 uc009pvx.4 
ENSMUST00000216933.2 Or5ak25 ENSMUST00000216933.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF74) ENSMUST00000216933.1 Olfr995 Or5ak25 Q8VF74 Q8VF74_MOUSE uc008kki.1 uc008kki.2 uc008kki.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kki.1 uc008kki.2 uc008kki.3 
ENSMUST00000216937.3 Or5p52 ENSMUST00000216937.3 Potential odorant receptor. (from UniProt Q8VG43) ENSMUST00000216937.1 ENSMUST00000216937.2 Mor204-5 O5P52_MOUSE Olfr472 Or5p52 Q8VG43 uc291ufq.1 uc291ufq.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ufq.1 uc291ufq.2 
ENSMUST00000216940.2 Gm47175 ENSMUST00000216940.2 Gm47175 (from geneSymbol) ENSMUST00000216940.1 uc292hls.1 uc292hls.2 uc292hls.1 uc292hls.2 
ENSMUST00000216941.2 Gm47271 ENSMUST00000216941.2 Gm47271 (from geneSymbol) ENSMUST00000216941.1 uc292htw.1 uc292htw.2 uc292htw.1 uc292htw.2 
ENSMUST00000216942.2 Or9a4 ENSMUST00000216942.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF31) ENSMUST00000216942.1 Olfr460 Or9a4 Q8VF31 Q8VF31_MOUSE uc009bmz.1 uc009bmz.2 uc009bmz.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009bmz.1 uc009bmz.2 uc009bmz.3 
ENSMUST00000216943.3 Gm47043 ENSMUST00000216943.3 Gm47043 (from geneSymbol) ENSMUST00000216943.1 ENSMUST00000216943.2 uc292meg.1 uc292meg.2 uc292meg.3 uc292meg.1 uc292meg.2 uc292meg.3 
ENSMUST00000216949.2 Or11g24 ENSMUST00000216949.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q1P0) E9Q1P0 E9Q1P0_MOUSE ENSMUST00000216949.1 Olfr739 Or11g24 uc288tln.1 uc288tln.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tln.1 uc288tln.2 
ENSMUST00000216950.2 Or4c11 ENSMUST00000216950.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2ATJ9) A2ATJ9 A2ATJ9_MOUSE ENSMUST00000216950.1 Olfr1206 Or4c11 uc289xzt.1 uc289xzt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xzt.1 uc289xzt.2 
ENSMUST00000216951.2 Or5d39 ENSMUST00000216951.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR26) ENSMUST00000216951.1 Olfr1167 Or5d39 Q7TR26 Q7TR26_MOUSE uc289xxn.1 uc289xxn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xxn.1 uc289xxn.2 
ENSMUST00000216957.3 Or5k3 ENSMUST00000216957.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGQ6) ENSMUST00000216957.1 ENSMUST00000216957.2 Olfr195 Or5k3 Q8VGQ6 Q8VGQ6_MOUSE uc007zot.1 uc007zot.2 uc007zot.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007zot.1 uc007zot.2 uc007zot.3 
ENSMUST00000216959.2 Gm48274 ENSMUST00000216959.2 Gm48274 (from geneSymbol) ENSMUST00000216959.1 uc287rbp.1 uc287rbp.2 uc287rbp.1 uc287rbp.2 
ENSMUST00000216960.2 Gm47327 ENSMUST00000216960.2 Gm47327 (from geneSymbol) ENSMUST00000216960.1 uc292gmc.1 uc292gmc.2 uc292gmc.1 uc292gmc.2 
ENSMUST00000216961.2 Or4c120 ENSMUST00000216961.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR01) ENSMUST00000216961.1 Olfr1225 Or4c120 Q7TR01 Q7TR01_MOUSE uc289ybg.1 uc289ybg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ybg.1 uc289ybg.2 
ENSMUST00000216965.2 Or2ab1 ENSMUST00000216965.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BQD6) A0A2I3BQD6 A0A2I3BQD6_MOUSE ENSMUST00000216965.1 Olfr324 Or2ab1 uc287ykh.1 uc287ykh.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ykh.1 uc287ykh.2 
ENSMUST00000216966.2 Or6c70 ENSMUST00000216966.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRH4) ENSMUST00000216966.1 Olfr814 Or6c70 Q7TRH4 Q7TRH4_MOUSE uc287vzs.1 uc287vzs.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vzs.1 uc287vzs.2 
ENSMUST00000216968.2 Or14a257 ENSMUST00000216968.2 Odorant receptor. (from UniProt Q7TS06) ENSMUST00000216968.1 Olfr298 Or14a257 Q7TS06 Q7TS06_MOUSE uc291sji.1 uc291sji.2 Odorant receptor. Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291sji.1 uc291sji.2 
ENSMUST00000216972.2 Gm47047 ENSMUST00000216972.2 Gm47047 (from geneSymbol) AK133060 ENSMUST00000216972.1 uc292ijq.1 uc292ijq.2 uc292ijq.1 uc292ijq.2 
ENSMUST00000216975.2 Gm48737 ENSMUST00000216975.2 Gm48737 (from geneSymbol) AK076168 ENSMUST00000216975.1 uc292ghp.1 uc292ghp.2 uc292ghp.1 uc292ghp.2 
ENSMUST00000216977.2 Or4a66 ENSMUST00000216977.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR14) A2AV15 ENSMUST00000216977.1 Olfr1196 Or4a66 Q7TR14 Q7TR14_MOUSE uc289xzf.1 uc289xzf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xzf.1 uc289xzf.2 
ENSMUST00000216978.2 Or4c100 ENSMUST00000216978.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR16) ENSMUST00000216978.1 Olfr1186 Or4c100 Q7TR16 Q7TR16_MOUSE uc289xyn.1 uc289xyn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xyn.1 uc289xyn.2 
ENSMUST00000216980.2 Or10q12 ENSMUST00000216980.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEZ4) ENSMUST00000216980.1 Olfr1495 Or10q12 Q8VEZ4 Q8VEZ4_MOUSE uc008gvy.1 uc008gvy.2 uc008gvy.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gvy.1 uc008gvy.2 uc008gvy.3 
ENSMUST00000216982.2 Or8b12 ENSMUST00000216982.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRE6) ENSMUST00000216982.1 Olfr874 Or8b12 Q7TRE6 Q7TRE6_MOUSE uc292fwi.1 uc292fwi.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fwi.1 uc292fwi.2 
ENSMUST00000216989.2 Or5b97 ENSMUST00000216989.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFX3) ENSMUST00000216989.1 Olfr1447 Or5b97 Q8VFX3 Q8VFX3_MOUSE uc008guu.1 uc008guu.2 uc008guu.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008guu.1 uc008guu.2 uc008guu.3 
ENSMUST00000217000.2 Or4c111 ENSMUST00000217000.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR05) ENSMUST00000217000.1 Olfr1216 Or4c111 Q7TR05 Q7TR05_MOUSE uc289yai.1 uc289yai.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yai.1 uc289yai.2 
ENSMUST00000217001.2 Or5b120 ENSMUST00000217001.2 olfactory receptor family 5 subfamily B member 120 (from RefSeq NM_146696.2) ENSMUST00000217001.1 NM_146696 Olfr1477 Or5b120 Q7TQQ7 Q7TQQ7_MOUSE uc008gvq.1 uc008gvq.2 uc008gvq.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB173171.1, CB174113.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gvq.1 uc008gvq.2 uc008gvq.3 
ENSMUST00000217005.2 Gm46102 ENSMUST00000217005.2 Gm46102 (from geneSymbol) ENSMUST00000217005.1 uc292ejz.1 uc292ejz.2 uc292ejz.1 uc292ejz.2 
ENSMUST00000217011.2 Gm49353 ENSMUST00000217011.2 Gm49353 (from geneSymbol) A0A1Y7VMI7 A0A1Y7VMI7_MOUSE BC138279 ENSMUST00000217011.1 Gm49353 uc287qgz.1 uc287qgz.2 membrane integral component of membrane uc287qgz.1 uc287qgz.2 
ENSMUST00000217012.3 Gm34654 ENSMUST00000217012.3 Gm34654 (from geneSymbol) ENSMUST00000217012.1 ENSMUST00000217012.2 uc292iyw.1 uc292iyw.2 uc292iyw.3 uc292iyw.1 uc292iyw.2 uc292iyw.3 
ENSMUST00000217016.2 Or1p1c ENSMUST00000217016.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRX0) ENSMUST00000217016.1 Olfr406 Olfr406-ps Or1p1c Q7TRX0 Q7TRX0_MOUSE uc007kbq.1 uc007kbq.2 uc007kbq.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007kbq.1 uc007kbq.2 uc007kbq.3 
ENSMUST00000217020.2 Gm29154 ENSMUST00000217020.2 Gm29154 (from geneSymbol) AK131742 ENSMUST00000217020.1 uc292kfw.1 uc292kfw.2 uc292kfw.1 uc292kfw.2 
ENSMUST00000217021.2 Gm32511 ENSMUST00000217021.2 predicted gene, 32511 (from RefSeq NR_110517.1) ENSMUST00000217021.1 NR_110517 uc033jlg.1 uc033jlg.2 uc033jlg.3 uc033jlg.1 uc033jlg.2 uc033jlg.3 
ENSMUST00000217023.3 Or10h28 ENSMUST00000217023.3 Odorant receptor. (from UniProt Q8VBW9) 10H28_MOUSE ENSMUST00000217023.1 ENSMUST00000217023.2 Mor267-1 Olfr63 Or10h28 Q8VBW9 uc008byg.1 uc008byg.2 uc008byg.3 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008byg.1 uc008byg.2 uc008byg.3 
ENSMUST00000217024.2 Or52r1 ENSMUST00000217024.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGZ2) ENSMUST00000217024.1 Olfr569 Or52r1 Q8VGZ2 Q8VGZ2_MOUSE uc291toe.1 uc291toe.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291toe.1 uc291toe.2 
ENSMUST00000217025.2 Or4k15c ENSMUST00000217025.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q8X3) A0A0U1RP52 E9Q8X3 E9Q8X3_MOUSE ENSMUST00000217025.1 Olfr726 Or4k15c uc288tkl.1 uc288tkl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tkl.1 uc288tkl.2 
ENSMUST00000217028.2 Gm47320 ENSMUST00000217028.2 Gm47320 (from geneSymbol) ENSMUST00000217028.1 uc292mda.1 uc292mda.2 uc292mda.1 uc292mda.2 
ENSMUST00000217036.2 Gm49323 ENSMUST00000217036.2 Gm49323 (from geneSymbol) BC141297 ENSMUST00000217036.1 uc292mor.1 uc292mor.2 uc292mor.1 uc292mor.2 
ENSMUST00000217043.3 Or8k40 ENSMUST00000217043.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGA6) ENSMUST00000217043.1 ENSMUST00000217043.2 Olfr1090 Or8k40 Q8VGA6 Q8VGA6_MOUSE uc289xta.1 uc289xta.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xta.1 uc289xta.2 
ENSMUST00000217044.2 4930543K20Rik ENSMUST00000217044.2 4930543K20Rik (from geneSymbol) AK019733 ENSMUST00000217044.1 uc287qnl.1 uc287qnl.2 uc287qnl.1 uc287qnl.2 
ENSMUST00000217053.2 ENSMUSG00000121452 ENSMUST00000217053.2 ENSMUSG00000121452 (from geneSymbol) ENSMUST00000217053.1 uc292mns.1 uc292mns.2 uc292mns.1 uc292mns.2 
ENSMUST00000217057.2 Or8b50 ENSMUST00000217057.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PW59) E9PW59 E9PW59_MOUSE ENSMUST00000217057.1 Olfr914 Or8b50 uc292fyl.1 uc292fyl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fyl.1 uc292fyl.2 
ENSMUST00000217061.3 Or5b123 ENSMUST00000217061.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFQ6) ENSMUST00000217061.1 ENSMUST00000217061.2 Olfr1487 Or5b123 Q8VFQ6 Q8VFQ6_MOUSE uc289rga.1 uc289rga.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rga.1 uc289rga.2 
ENSMUST00000217062.3 Or5an6 ENSMUST00000217062.3 Odorant receptor involved in the detection of muscone. (from UniProt Q8VFV4) ENSMUST00000217062.1 ENSMUST00000217062.2 Mor215-1 O5AN6_MOUSE Olfr1440 Or5an6 Q8VFV4 uc289rbv.1 uc289rbv.2 Odorant receptor involved in the detection of muscone. Cell membrane ; Multi-pass membrane protein Localized in the dorsomedial and ventral region of the olfactory bulb. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rbv.1 uc289rbv.2 
ENSMUST00000217063.2 Or8c20 ENSMUST00000217063.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1SRP1) A0A1L1SRP1 A0A1L1SRP1_MOUSE ENSMUST00000217063.1 Olfr898 Or8c20 uc292fxu.1 uc292fxu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fxu.1 uc292fxu.2 
ENSMUST00000217066.3 Or5aq6 ENSMUST00000217066.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AT96) A2AT96 A2AT96_MOUSE ENSMUST00000217066.1 ENSMUST00000217066.2 Olfr1109 Olfr1110 Or5aq6 uc289xtw.1 uc289xtw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xtw.1 uc289xtw.2 
ENSMUST00000217068.2 Gm39375 ENSMUST00000217068.2 Gm39375 (from geneSymbol) ENSMUST00000217068.1 uc292izg.1 uc292izg.2 uc292izg.1 uc292izg.2 
ENSMUST00000217069.2 Gm47388 ENSMUST00000217069.2 Gm47388 (from geneSymbol) AK028854 ENSMUST00000217069.1 uc287qyc.1 uc287qyc.2 uc287qyc.1 uc287qyc.2 
ENSMUST00000217071.2 Gm47354 ENSMUST00000217071.2 Gm47354 (from geneSymbol) ENSMUST00000217071.1 uc287raf.1 uc287raf.2 uc287raf.1 uc287raf.2 
ENSMUST00000217077.2 Gm9856 ENSMUST00000217077.2 predicted gene 9856 (from RefSeq NR_188868.1) ENSMUST00000217077.1 NR_188868 uc292moo.1 uc292moo.2 uc292moo.1 uc292moo.2 
ENSMUST00000217080.3 Gm48803 ENSMUST00000217080.3 Gm48803 (from geneSymbol) ENSMUST00000217080.1 ENSMUST00000217080.2 uc292fju.1 uc292fju.2 uc292fju.3 uc292fju.1 uc292fju.2 uc292fju.3 
ENSMUST00000217082.2 A730065G17Rik ENSMUST00000217082.2 A730065G17Rik (from geneSymbol) AK139201 ENSMUST00000217082.1 uc292hao.1 uc292hao.2 uc292hao.1 uc292hao.2 
ENSMUST00000217087.2 Gm34973 ENSMUST00000217087.2 Gm34973 (from geneSymbol) ENSMUST00000217087.1 uc292eqq.1 uc292eqq.2 uc292eqq.1 uc292eqq.2 
ENSMUST00000217092.2 Zbtb44 ENSMUST00000217092.2 Nucleus (from UniProt A0A1L1SSL7) A0A1L1SSL7 A0A1L1SSL7_MOUSE AK036895 ENSMUST00000217092.1 Zbtb44 uc292flm.1 uc292flm.2 Nucleus nucleic acid binding uc292flm.1 uc292flm.2 
ENSMUST00000217094.2 Or6c210 ENSMUST00000217094.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFH7) D3YWR4 ENSMUST00000217094.1 Olfr800 Or6c210 Q8VFH7 Q8VFH7_MOUSE uc007hqh.1 uc007hqh.2 uc007hqh.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007hqh.1 uc007hqh.2 uc007hqh.3 
ENSMUST00000217099.2 Gm47824 ENSMUST00000217099.2 Gm47824 (from geneSymbol) AK157460 ENSMUST00000217099.1 uc292iyz.1 uc292iyz.2 uc292iyz.1 uc292iyz.2 
ENSMUST00000217106.2 Or6c214 ENSMUST00000217106.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGI9) ENSMUST00000217106.1 Olfr807 Or6c214 Q8VGI9 Q8VGI9_MOUSE uc287vzd.1 uc287vzd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vzd.1 uc287vzd.2 
ENSMUST00000217109.2 Gm33180 ENSMUST00000217109.2 Gm33180 (from geneSymbol) AK139643 ENSMUST00000217109.1 uc292hul.1 uc292hul.2 uc292hul.1 uc292hul.2 
ENSMUST00000217112.2 Or4d1 ENSMUST00000217112.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5SW48) ENSMUST00000217112.1 Olfr464 Or4d1 Q5SW48 Q5SW48_MOUSE uc288bga.1 uc288bga.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288bga.1 uc288bga.2 
ENSMUST00000217113.2 Or5w22 ENSMUST00000217113.2 olfactory receptor family 5 subfamily W member 22 (from RefSeq NM_206823.1) ENSMUST00000217113.1 NM_206823 Olfr153 Or5w22 Q7TR48 Q7TR48_MOUSE uc008koc.1 uc008koc.2 uc008koc.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008koc.1 uc008koc.2 uc008koc.3 
ENSMUST00000217114.3 Or8b54 ENSMUST00000217114.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRC0) A0A1L1SUQ3 ENSMUST00000217114.1 ENSMUST00000217114.2 F8VQ31 Olfr921 Or8b54 Q7TRC0 Q7TRC0_MOUSE uc033jjv.1 uc033jjv.2 uc033jjv.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033jjv.1 uc033jjv.2 uc033jjv.3 
ENSMUST00000217125.3 4933404K13Rik ENSMUST00000217125.3 4933404K13Rik (from geneSymbol) AK016653 ENSMUST00000217125.1 ENSMUST00000217125.2 uc287qxe.1 uc287qxe.2 uc287qxe.3 uc287qxe.1 uc287qxe.2 uc287qxe.3 
ENSMUST00000217127.2 Gm47403 ENSMUST00000217127.2 Gm47403 (from geneSymbol) ENSMUST00000217127.1 uc292jnj.1 uc292jnj.2 uc292jnj.1 uc292jnj.2 
ENSMUST00000217131.2 Or4c101 ENSMUST00000217131.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR15) ENSMUST00000217131.1 Olfr1188 Or4c101 Q7TR15 Q7TR15_MOUSE uc289xyq.1 uc289xyq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xyq.1 uc289xyq.2 
ENSMUST00000217136.2 Or56a4 ENSMUST00000217136.2 Membrane ; Multi- pass membrane protein (from UniProt Q7TRN8) ENSMUST00000217136.1 Olfr684 Or56a4 Q7TRN8 Q7TRN8_MOUSE uc291twy.1 uc291twy.2 Membrane ; Multi- pass membrane protein dopamine neurotransmitter receptor activity, coupled via Gi/Go synaptic transmission, dopaminergic G-protein coupled receptor activity adrenergic receptor activity olfactory receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway sensory perception of smell response to toxic substance regulation of dopamine secretion membrane integral component of membrane synaptic vesicle membrane dopamine binding response to drug regulation of potassium ion transport behavioral response to cocaine behavioral response to ethanol response to stimulus detection of chemical stimulus involved in sensory perception of smell negative regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway negative regulation of synaptic transmission, glutamatergic phospholipase C-activating dopamine receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway negative regulation of voltage-gated calcium channel activity uc291twy.1 uc291twy.2 
ENSMUST00000217152.2 Or4m1 ENSMUST00000217152.2 Olfactory receptor that acts as a receptor of Asprosin hormone at the surface of hepatocytes to promote hepatocyte glucose release (PubMed:31230984). Also binds Asprosin in the arcuate nucleus of the hypothalamus, thereby stimulating appetite by promoting orexigenic AgRP neuronal activity (PubMed:32337066). In testis, Asprosin-binding promotes sperm progressive motility and enhances male fertility (PubMed:31798959). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase, resulting in an elevation of intracellular cAMP (PubMed:31230984). (from UniProt Q8VFT4) ENSMUST00000217152.1 OR4M1_MOUSE Olfr734 Or4m1 Q8VFT4 uc007tkx.1 uc007tkx.2 uc007tkx.3 Olfactory receptor that acts as a receptor of Asprosin hormone at the surface of hepatocytes to promote hepatocyte glucose release (PubMed:31230984). Also binds Asprosin in the arcuate nucleus of the hypothalamus, thereby stimulating appetite by promoting orexigenic AgRP neuronal activity (PubMed:32337066). In testis, Asprosin-binding promotes sperm progressive motility and enhances male fertility (PubMed:31798959). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase, resulting in an elevation of intracellular cAMP (PubMed:31230984). Cell membrane ; Multi-pass membrane protein Highly expressed in liver but not in adipose tissue (PubMed:31230984). Also expressed at high level in testis (PubMed:31798959). Compared to wild-type mice, mutant mice fed on a regular diet show a remarkable decrease in body weight, food intake, fat mass and plasma lipids (PubMed:31230984). Blunted response to Asprosin, including attenuated cAMP levels and hepatic glucose production, as well as improved insulin sensitivity (PubMed:31230984). Mutant mice show significantly reduced food intake in overnight-fasted mice compared with wild-type mice (PubMed:32337066). Male mice display decreased fertility caused by impaired sperm motility (PubMed:31798959). The mouse olfactory receptor 4M1 (Q8VFT4) is not the one to one ortholog of human OR4M1 (Q8NGD0). Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007tkx.1 uc007tkx.2 uc007tkx.3 
ENSMUST00000217153.2 Gm47122 ENSMUST00000217153.2 Gm47122 (from geneSymbol) ENSMUST00000217153.1 LF197883 uc292mlk.1 uc292mlk.2 uc292mlk.1 uc292mlk.2 
ENSMUST00000217156.2 Gm47248 ENSMUST00000217156.2 Gm47248 (from geneSymbol) ENSMUST00000217156.1 uc291ttj.1 uc291ttj.2 uc291ttj.1 uc291ttj.2 
ENSMUST00000217157.2 Actn4 ENSMUST00000217157.2 actinin alpha 4, transcript variant 9 (from RefSeq NM_001420187.1) A0A1L1SV25 A0A1L1SV25_MOUSE Actn4 ENSMUST00000217157.1 NM_001420187 uc291nnf.1 uc291nnf.2 Cell junction Cytoplasm, cytoskeleton, stress fiber Cytoplasm, perinuclear region Belongs to the alpha-actinin family. actin binding calcium ion binding uc291nnf.1 uc291nnf.2 
ENSMUST00000217160.3 Or8b48 ENSMUST00000217160.3 olfactory receptor family 8 subfamily B member 48 (from RefSeq NM_146810.2) A0A1L1SSS5 A0A1L1SSS5_MOUSE ENSMUST00000217160.1 ENSMUST00000217160.2 NM_146810 Olfr912 Or8b48 uc009ows.1 uc009ows.2 uc009ows.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB174120.1, CB174208.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ows.1 uc009ows.2 uc009ows.3 
ENSMUST00000217162.2 Gm47111 ENSMUST00000217162.2 Gm47111 (from geneSymbol) ENSMUST00000217162.1 LF197878 uc292mke.1 uc292mke.2 uc292mke.1 uc292mke.2 
ENSMUST00000217166.2 Or5j3 ENSMUST00000217166.2 Potential odorant receptor. (from UniProt Q8VGR8) A0PK46 A2AVX6 ENSMUST00000217166.1 Mor172-1 OR5J3_MOUSE Olfr1052 Or5j3 Q8VGR8 uc008kmb.1 uc008kmb.2 uc008kmb.3 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kmb.1 uc008kmb.2 uc008kmb.3 
ENSMUST00000217167.2 Or2j6 ENSMUST00000217167.2 olfactory receptor family 2 subfamily J member 6 (from RefSeq NM_146953.1) ENSMUST00000217167.1 NM_146953 Olfr531 Or2j6 Q8VGL2 Q8VGL2_MOUSE uc291wul.1 uc291wul.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC104052.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291wul.1 uc291wul.2 
ENSMUST00000217173.2 Or5p55 ENSMUST00000217173.2 Potential odorant receptor. (from UniProt Q8VGI4) ENSMUST00000217173.1 Mor204-3 O5P55_MOUSE Olfr476 Or5p55 Q8VGI4 uc291ufu.1 uc291ufu.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ufu.1 uc291ufu.2 
ENSMUST00000217177.2 Or52n2b ENSMUST00000217177.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRP4) ENSMUST00000217177.1 Olfr667 Or52n2b Q7TRP4 Q7TRP4_MOUSE uc291tvl.1 uc291tvl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tvl.1 uc291tvl.2 
ENSMUST00000217178.2 Nlrp4g ENSMUST00000217178.2 Nlrp4g (from geneSymbol) AK136247 ENSMUST00000217178.1 uc292msc.1 uc292msc.2 uc292msc.1 uc292msc.2 
ENSMUST00000217182.3 Or5b124 ENSMUST00000217182.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFQ5) ENSMUST00000217182.1 ENSMUST00000217182.2 Olfr1489 Or5b124 Q8VFQ5 Q8VFQ5_MOUSE uc008gvu.1 uc008gvu.2 uc008gvu.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gvu.1 uc008gvu.2 uc008gvu.3 
ENSMUST00000217183.2 Gm47181 ENSMUST00000217183.2 Gm47181 (from geneSymbol) ENSMUST00000217183.1 uc292mse.1 uc292mse.2 uc292mse.1 uc292mse.2 
ENSMUST00000217198.2 Olfm2 ENSMUST00000217198.2 olfactomedin 2, transcript variant 1 (from RefSeq NM_001357635.1) A0A1L1SV46 A0A1L1SV46_MOUSE ENSMUST00000217198.1 NM_001357635 Olfm2 uc292exq.1 uc292exq.2 Secreted Synapse uc292exq.1 uc292exq.2 
ENSMUST00000217203.2 Gsta13 ENSMUST00000217203.2 glutathione S-transferase alpha 13 (from RefSeq NM_001243092.1) ENSMUST00000217203.1 Gm3776 Gsta1 NM_001243092 Q6P8Q0 Q6P8Q0_MOUSE uc009qub.1 uc009qub.2 uc009qub.3 Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16438; Evidence=; Belongs to the GST superfamily. Alpha family. molecular_function glutathione transferase activity cellular_component cytosol glutathione metabolic process xenobiotic metabolic process biological_process transferase activity uc009qub.1 uc009qub.2 uc009qub.3 
ENSMUST00000217206.2 A930033M14Rik ENSMUST00000217206.2 A930033M14Rik (from geneSymbol) AK020925 ENSMUST00000217206.1 uc287qqx.1 uc287qqx.2 uc287qqx.1 uc287qqx.2 
ENSMUST00000217207.2 Gm47436 ENSMUST00000217207.2 Gm47436 (from geneSymbol) ENSMUST00000217207.1 uc292fnb.1 uc292fnb.2 uc292fnb.1 uc292fnb.2 
ENSMUST00000217208.3 Or8d23 ENSMUST00000217208.3 Membrane ; Multi- pass membrane protein (from UniProt Q9EQ99) ENSMUST00000217208.1 ENSMUST00000217208.2 Olfr930 Or8d23 Q9EQ99 Q9EQ99_MOUSE uc009oxj.1 uc009oxj.2 uc009oxj.3 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oxj.1 uc009oxj.2 uc009oxj.3 
ENSMUST00000217210.2 Gm47214 ENSMUST00000217210.2 Gm47214 (from geneSymbol) ENSMUST00000217210.1 uc292eoq.1 uc292eoq.2 uc292eoq.1 uc292eoq.2 
ENSMUST00000217211.3 Gm38398 ENSMUST00000217211.3 Gm38398 (from geneSymbol) ENSMUST00000217211.1 ENSMUST00000217211.2 uc292jfa.1 uc292jfa.2 uc292jfa.3 uc292jfa.1 uc292jfa.2 uc292jfa.3 
ENSMUST00000217215.3 Or1n1b ENSMUST00000217215.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGK0) ENSMUST00000217215.1 ENSMUST00000217215.2 Olfr351 Olfr353 Or1n1b Q8VGK0 Q8VGK0_MOUSE uc289vpv.1 uc289vpv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vpv.1 uc289vpv.2 
ENSMUST00000217218.3 Or5ak24 ENSMUST00000217218.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF73) ENSMUST00000217218.1 ENSMUST00000217218.2 Olfr994 Or5ak24 Q8VF73 Q8VF73_MOUSE uc289xoq.1 uc289xoq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xoq.1 uc289xoq.2 
ENSMUST00000217219.2 Or6c212 ENSMUST00000217219.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFI4) ENSMUST00000217219.1 Olfr805 Olfr811 Or6c212 Q8VFI4 Q8VFI4_MOUSE uc287vyy.1 uc287vyy.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vyy.1 uc287vyy.2 
ENSMUST00000217222.2 Gm47183 ENSMUST00000217222.2 Gm47183 (from geneSymbol) ENSMUST00000217222.1 uc292mso.1 uc292mso.2 uc292mso.1 uc292mso.2 
ENSMUST00000217223.2 Or14j6 ENSMUST00000217223.2 Odorant receptor. (from UniProt Q8VF25) ENSMUST00000217223.1 Olfr127 Or14j6 Q7TRJ2 Q8VF25 Q8VF25_MOUSE uc008cns.1 uc008cns.2 uc008cns.3 Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008cns.1 uc008cns.2 uc008cns.3 
ENSMUST00000217227.2 Or10d3 ENSMUST00000217227.2 Potential odorant receptor. (from UniProt Q8VEY3) ENSMUST00000217227.1 Mor224-9 O10D3_MOUSE Olfr958 Or10d3 Q8VEY3 uc292gbh.1 uc292gbh.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gbh.1 uc292gbh.2 
ENSMUST00000217228.2 Or6c2 ENSMUST00000217228.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGJ0) ENSMUST00000217228.1 Olfr791 Or6c2 Q8VGJ0 Q8VGJ0_MOUSE uc287vya.1 uc287vya.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vya.1 uc287vya.2 
ENSMUST00000217236.2 Tex12 ENSMUST00000217236.2 Component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:16968740). Requires SYCP1 in order to be incorporated into the central element (PubMed:16968740). (from UniProt Q9CR81) AK014896 ENSMUST00000217236.1 Q9CR81 TEX12_MOUSE uc009pjs.1 uc009pjs.2 uc009pjs.3 Component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:16968740). Requires SYCP1 in order to be incorporated into the central element (PubMed:16968740). Interacts with SYCE2. Chromosome te=In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Testis (at protein level) (PubMed:11279525, PubMed:16968740). Detected in ovary (PubMed:16968740). Expressed in both male and female germ cells (PubMed:16968740). meiotic DNA repair synthesis synaptonemal complex central element protein binding nucleoplasm synaptonemal complex assembly uc009pjs.1 uc009pjs.2 uc009pjs.3 
ENSMUST00000217237.2 Or4a39 ENSMUST00000217237.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG59) ENSMUST00000217237.1 Olfr1238 Or4a39 Q8VG59 Q8VG59_MOUSE uc289yci.1 uc289yci.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yci.1 uc289yci.2 
ENSMUST00000217239.2 Gm39348 ENSMUST00000217239.2 Gm39348 (from geneSymbol) AK041708 ENSMUST00000217239.1 uc292hxl.1 uc292hxl.2 uc292hxl.1 uc292hxl.2 
ENSMUST00000217243.2 Gm47148 ENSMUST00000217243.2 Gm47148 (from geneSymbol) AK084221 ENSMUST00000217243.1 uc292moi.1 uc292moi.2 uc292moi.1 uc292moi.2 
ENSMUST00000217244.2 Or5m11b ENSMUST00000217244.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2ATE0) A2ATE0 A2ATE0_MOUSE ENSMUST00000217244.1 Olfr1029 Or5m11b uc289xqd.1 uc289xqd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xqd.1 uc289xqd.2 
ENSMUST00000217250.2 Or51l14 ENSMUST00000217250.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGZ8) ENSMUST00000217250.1 Olfr606 Or51l14 Q8VGZ8 Q8VGZ8_MOUSE uc291tqj.1 uc291tqj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tqj.1 uc291tqj.2 
ENSMUST00000217253.2 Or14c43 ENSMUST00000217253.2 Odorant receptor. (from UniProt Q7TS05) ENSMUST00000217253.1 Olfr299 Or14c43 Q7TS05 Q7TS05_MOUSE uc291sjf.1 uc291sjf.2 Odorant receptor. Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291sjf.1 uc291sjf.2 
ENSMUST00000217257.2 Or8g50 ENSMUST00000217257.2 Odorant receptor. (from UniProt Q60895) E9QLS5 ENSMUST00000217257.1 Mor171-18 O8G50_MOUSE Olfr150 Olfr7 Or8g50 Q60895 Q8VFN2 uc292gcb.1 uc292gcb.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. dopamine neurotransmitter receptor activity, coupled via Gi/Go synaptic transmission, dopaminergic G-protein coupled receptor activity adrenergic receptor activity olfactory receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway sensory perception of smell response to toxic substance regulation of dopamine secretion membrane integral component of membrane synaptic vesicle membrane dopamine binding response to drug regulation of potassium ion transport behavioral response to cocaine behavioral response to ethanol response to stimulus detection of chemical stimulus involved in sensory perception of smell negative regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway negative regulation of synaptic transmission, glutamatergic phospholipase C-activating dopamine receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway negative regulation of voltage-gated calcium channel activity uc292gcb.1 uc292gcb.2 
ENSMUST00000217273.2 Or7g30 ENSMUST00000217273.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFF6) ENSMUST00000217273.1 Olfr849 Or7g30 Q8VFF6 Q8VFF6_MOUSE uc292etw.1 uc292etw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292etw.1 uc292etw.2 
ENSMUST00000217275.2 Or2y1f ENSMUST00000217275.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFA6) ENSMUST00000217275.1 Olfr1392 Or2y1f Q8VFA6 Q8VFA6_MOUSE uc287xtj.1 uc287xtj.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xtj.1 uc287xtj.2 
ENSMUST00000217279.2 Or10a3b ENSMUST00000217279.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFZ5) ENSMUST00000217279.1 F7B163 Olfr516 Olfr519 Or10a3b Q8VFZ5 Q8VFZ5_MOUSE uc291uhv.1 uc291uhv.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uhv.1 uc291uhv.2 
ENSMUST00000217281.2 Or10v1 ENSMUST00000217281.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF55) ENSMUST00000217281.1 Olfr1420 Or10v1 Q8VF55 Q8VF55_MOUSE uc008gtg.1 uc008gtg.2 uc008gtg.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gtg.1 uc008gtg.2 uc008gtg.3 
ENSMUST00000217286.2 Or8b40 ENSMUST00000217286.2 olfactory receptor family 8 subfamily B member 40 (from RefSeq NM_146482.1) ENSMUST00000217286.1 NM_146482 Olfr889 Or8b40 Q9EQA4 Q9EQA4_MOUSE uc009ovx.1 uc009ovx.2 uc009ovx.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009ovx.1 uc009ovx.2 uc009ovx.3 
ENSMUST00000217287.2 4632418H02Rik ENSMUST00000217287.2 4632418H02Rik (from geneSymbol) ENSMUST00000217287.1 LF197883 uc292mll.1 uc292mll.2 uc292mll.1 uc292mll.2 
ENSMUST00000217288.2 Gm48611 ENSMUST00000217288.2 Gm48611 (from geneSymbol) ENSMUST00000217288.1 uc292gfj.1 uc292gfj.2 uc292gfj.1 uc292gfj.2 
ENSMUST00000217290.2 Or2y1b ENSMUST00000217290.2 Odorant receptor. (from UniProt Q60883) A7E1Z7 ENSMUST00000217290.1 O2Y1B_MOUSE Olfr10 Or2y1b Q60883 Q7TQS9 uc007iqh.1 uc007iqh.2 uc007iqh.3 Odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007iqh.1 uc007iqh.2 uc007iqh.3 
ENSMUST00000217292.3 Or8k41 ENSMUST00000217292.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1SR98) A0A1L1SR98 A0A1L1SR98_MOUSE ENSMUST00000217292.1 ENSMUST00000217292.2 Olfr228 Or8k41 uc289xsk.1 uc289xsk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xsk.1 uc289xsk.2 
ENSMUST00000217293.2 Or51ac3 ENSMUST00000217293.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q3KPB0) ENSMUST00000217293.1 Olfr616 Or51ac3 Q3KPB0 Q3KPB0_MOUSE uc291tqy.1 uc291tqy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tqy.1 uc291tqy.2 
ENSMUST00000217298.2 Or1l4b ENSMUST00000217298.2 Membrane ; Multi- pass membrane protein (from UniProt A0A140T8Q2) A0A140T8Q2 A0A140T8Q2_MOUSE ENSMUST00000217298.1 Olfr364 Or1l4b uc289vqn.1 uc289vqn.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vqn.1 uc289vqn.2 
ENSMUST00000217299.3 Or5c1 ENSMUST00000217299.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF22) ENSMUST00000217299.1 ENSMUST00000217299.2 Olfr368 Or5c1 Q8VF22 Q8VF22_MOUSE uc008jmo.1 uc008jmo.2 uc008jmo.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008jmo.1 uc008jmo.2 uc008jmo.3 
ENSMUST00000217304.2 Or5p58 ENSMUST00000217304.2 Potential odorant receptor. (from UniProt Q8VG03) ENSMUST00000217304.1 Mor204-14 O5P58_MOUSE Olfr482 Or5p58 Q8VG03 uc291ugd.1 uc291ugd.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ugd.1 uc291ugd.2 
ENSMUST00000217308.3 Fat3 ENSMUST00000217308.3 FAT atypical cadherin 3, transcript variant 1 (from RefSeq NM_001413471.1) ENSMUST00000217308.1 ENSMUST00000217308.2 FAT3_MOUSE Gm1132 Gm510 NM_001413471 Q08ED4 Q8BNA6 uc009ogj.1 uc009ogj.2 uc009ogj.3 uc009ogj.4 May play a role in the interactions between neurites derived from specific subsets of neurons during development. Membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BNA6-1; Sequence=Displayed; Name=2; IsoId=Q8BNA6-2; Sequence=VSP_032330, VSP_032331; Name=3; IsoId=Q8BNA6-3; Sequence=VSP_032329, VSP_032332, VSP_032333; Restricted to the nervous system, mainly in brain. In brain, it is highly expressed in the olfactory bulb and retina. In the developing olfactory bulb, it localizes along the dendrites of these cells as well as in their axons to some extent. In retina, it cocentrates in the inner plexiform layer throughout development (at protein level). cell morphogenesis involved in differentiation neuron migration calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules multicellular organism development retina layer formation membrane integral component of membrane dendrite cell-cell adhesion negative regulation of dendrite development uc009ogj.1 uc009ogj.2 uc009ogj.3 uc009ogj.4 
ENSMUST00000217313.2 Or6d14 ENSMUST00000217313.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG27) ENSMUST00000217313.1 Olfr214 Or6d14 Q8VG27 Q8VG27_MOUSE uc291idn.1 uc291idn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291idn.1 uc291idn.2 
ENSMUST00000217315.2 Gm47392 ENSMUST00000217315.2 Gm47392 (from geneSymbol) AK139514 ENSMUST00000217315.1 uc287qyf.1 uc287qyf.2 uc287qyf.1 uc287qyf.2 
ENSMUST00000217316.2 Or9s14 ENSMUST00000217316.2 olfactory receptor family 9 subfamily S member 14 (from RefSeq NM_146491.1) ENSMUST00000217316.1 NM_146491 Olfr1410 Or9s14 Q8VFC5 Q8VFC5_MOUSE uc007cbo.1 uc007cbo.2 uc007cbo.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC106991.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007cbo.1 uc007cbo.2 uc007cbo.3 
ENSMUST00000217325.2 Or1j20 ENSMUST00000217325.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGJ9) ENSMUST00000217325.1 Olfr352 Or1j20 Q8VGJ9 Q8VGJ9_MOUSE uc289vpu.1 uc289vpu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vpu.1 uc289vpu.2 
ENSMUST00000217329.2 Gm47231 ENSMUST00000217329.2 Gm47231 (from geneSymbol) ENSMUST00000217329.1 uc292gqq.1 uc292gqq.2 uc292gqq.1 uc292gqq.2 
ENSMUST00000217333.2 B020014A21Rik ENSMUST00000217333.2 RIKEN cDNA B020014A21 gene (from RefSeq NR_045946.1) ENSMUST00000217333.1 NR_045946 uc029qvj.1 uc029qvj.2 uc029qvj.1 uc029qvj.2 
ENSMUST00000217336.2 Dock6 ENSMUST00000217336.2 dedicator of cytokinesis 6, transcript variant 1 (from RefSeq NM_177030.4) A0A1L1SQR4 A0A1L1SQR4_MOUSE Dock6 ENSMUST00000217336.1 NM_177030 uc033jjl.1 uc033jjl.2 uc033jjl.3 Belongs to the DOCK family. guanyl-nucleotide exchange factor activity cytosol small GTPase mediated signal transduction uc033jjl.1 uc033jjl.2 uc033jjl.3 
ENSMUST00000217342.2 Or4c118 ENSMUST00000217342.2 olfactory receptor family 4 subfamily C member 118 (from RefSeq NM_146892.2) A0A1L1SU13 A0A1L1SU13_MOUSE ENSMUST00000217342.1 NM_146892 Olfr1223 Or4c118 uc008kra.1 uc008kra.2 uc008kra.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: CB174130.1, CB174244.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kra.1 uc008kra.2 uc008kra.3 
ENSMUST00000217344.3 ENSMUSG00000121783 ENSMUST00000217344.3 ENSMUSG00000121783 (from geneSymbol) AK160389 ENSMUST00000217344.1 ENSMUST00000217344.2 uc287qzl.1 uc287qzl.2 uc287qzl.3 uc287qzl.1 uc287qzl.2 uc287qzl.3 
ENSMUST00000217345.2 Gm47652 ENSMUST00000217345.2 Gm47652 (from geneSymbol) AK191567 ENSMUST00000217345.1 uc292fus.1 uc292fus.2 uc292fus.1 uc292fus.2 
ENSMUST00000217350.2 Or8d2 ENSMUST00000217350.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRB8) ENSMUST00000217350.1 Olfr924 Or8d2 Q7TRB8 Q7TRB8_MOUSE uc292fzj.1 uc292fzj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292fzj.1 uc292fzj.2 
ENSMUST00000217355.3 Or11n2 ENSMUST00000217355.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQW3) ENSMUST00000217355.1 ENSMUST00000217355.2 Olfr1322 Or11n2 Q7TQW3 Q7TQW3_MOUSE uc292obv.1 uc292obv.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292obv.1 uc292obv.2 
ENSMUST00000217359.2 Gm38431 ENSMUST00000217359.2 predicted gene, 38431 (from RefSeq NR_038081.2) ENSMUST00000217359.1 Kiaa1978 NR_038081 Q5DTT6 Q811K0 Q8C3Z1 Q8CA14 Q9CW46 RAVR1_MOUSE Raver1 uc292ezb.1 uc292ezb.2 This gene represents a read-through transcript composed of Raver1 and Fdx1l sequence. This transcript is thought to be non-coding because it would be subject to nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Apr 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK004919.1, AY275472.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 68165, 71766 ##RefSeq-Attributes-END## Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Interacts with PTBP1, RAVER2, VCL and ACTN1. Part of a complex containing RAVER1, VCL and ACTN1. Nucleus Cytoplasm Note=Nuclear, in perinucleolar structures. Shuttles between nucleus and cytoplasm. Cytoplasm, at focal contacts and cell-cell contacts. Associated with myotubes during muscle differentiation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CW46-1; Sequence=Displayed; Name=2; IsoId=Q9CW46-2; Sequence=VSP_017037, VSP_017038; Ubiquitous. Sequence=BAB23670.1; Type=Erroneous initiation; Evidence=; nucleic acid binding RNA binding nucleus cytoplasm uc292ezb.1 uc292ezb.2 
ENSMUST00000217363.2 Gm48545 ENSMUST00000217363.2 Gm48545 (from geneSymbol) AK133225 ENSMUST00000217363.1 uc287pvd.1 uc287pvd.2 uc287pvd.1 uc287pvd.2 
ENSMUST00000217364.2 Or6c209 ENSMUST00000217364.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGI7) ENSMUST00000217364.1 Olfr799 Or6c209 Q8VGI7 Q8VGI7_MOUSE uc287vym.1 uc287vym.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vym.1 uc287vym.2 
ENSMUST00000217368.2 Or5w1b ENSMUST00000217368.2 Membrane ; Multi- pass membrane protein (from UniProt Q7TR44) ENSMUST00000217368.1 Olfr1133 Or5w1b Q7TR44 Q7TR44_MOUSE uc289xwa.1 uc289xwa.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xwa.1 uc289xwa.2 
ENSMUST00000217369.2 Gm47559 ENSMUST00000217369.2 Gm47559 (from geneSymbol) ENSMUST00000217369.1 uc292emn.1 uc292emn.2 uc292emn.1 uc292emn.2 
ENSMUST00000217371.2 Igdcc3 ENSMUST00000217371.2 immunoglobulin superfamily, DCC subclass, member 3, transcript variant 1 (from RefSeq NM_001357257.1) ENSMUST00000217371.1 IGDC3_MOUSE NM_001357257 O70246 Punc Q792T2 Q8BQC3 Q9Z2S6 uc009qcw.1 uc009qcw.2 uc009qcw.3 uc009qcw.4 Membrane ; Single-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BQC3-1; Sequence=Displayed; Name=2; IsoId=Q8BQC3-2; Sequence=VSP_012321; Detected in cerebellum, kidney, heart, lung, skeletal muscle and spleen. Strongly expressed in embryos from 9.5 dpc to 10.5 dpc. Expression is much lower at 11.5 dpc and virtually extinct at 15.5 dpc. Detected in neural tube and lateral mesoderm at 9.5 dpc. At 10.5 dpc detected in fore and hind limb buds and lateral plate mesoderm, throughout the neural tube, in mesencephalon and dorsal diencephalon. Belongs to the immunoglobulin superfamily. DCC family. molecular_function cellular_component integral component of plasma membrane membrane integral component of membrane neuromuscular process controlling balance uc009qcw.1 uc009qcw.2 uc009qcw.3 uc009qcw.4 
ENSMUST00000217372.2 Or2h1 ENSMUST00000217372.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRL3) ENSMUST00000217372.1 Olfr91 Or2h1 Q7TRL3 Q7TRL3_MOUSE uc289kxs.1 uc289kxs.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kxs.1 uc289kxs.2 
ENSMUST00000217374.2 Or10j3b ENSMUST00000217374.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGE1) ENSMUST00000217374.1 Olfr1404 Or10j3b Q8VGE1 Q8VGE1_MOUSE uc287nzz.1 uc287nzz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287nzz.1 uc287nzz.2 
ENSMUST00000217376.2 Or5w8 ENSMUST00000217376.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFQ8) ENSMUST00000217376.1 Olfr1151 Or5w8 Q8VFQ8 Q8VFQ8_MOUSE uc289xwu.1 uc289xwu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xwu.1 uc289xwu.2 
ENSMUST00000217377.2 Or5k14 ENSMUST00000217377.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q7W1) E9Q7W1 E9Q7W1_MOUSE ENSMUST00000217377.1 Olfr177 Or5k14 uc289ffg.1 uc289ffg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ffg.1 uc289ffg.2 
ENSMUST00000217379.2 Or4s2 ENSMUST00000217379.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1STD5) A0A1L1STD5 A0A1L1STD5_MOUSE ENSMUST00000217379.1 Olfr1191 Or4s2 uc289xyv.1 uc289xyv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xyv.1 uc289xyv.2 
ENSMUST00000217384.2 Or9q2 ENSMUST00000217384.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VG11) ENSMUST00000217384.1 Olfr1497 Or9q2 Q8VG11 Q8VG11_MOUSE uc289rgy.1 uc289rgy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rgy.1 uc289rgy.2 
ENSMUST00000217391.2 Gm47037 ENSMUST00000217391.2 Gm47037 (from geneSymbol) AK042802 ENSMUST00000217391.1 uc292ekt.1 uc292ekt.2 uc292ekt.1 uc292ekt.2 
ENSMUST00000217402.2 Or4a72 ENSMUST00000217402.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1SQJ6) A0A1L1SQJ6 A0A1L1SQJ6_MOUSE ENSMUST00000217402.1 Olfr1245 Or4a72 uc289ycv.1 uc289ycv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289ycv.1 uc289ycv.2 
ENSMUST00000217403.2 Or8h7 ENSMUST00000217403.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AVA9) A2AVA9 A2AVA9_MOUSE ENSMUST00000217403.1 Olfr1097 Olfr1098 Or8h7 uc033hnw.1 uc033hnw.2 uc033hnw.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033hnw.1 uc033hnw.2 uc033hnw.3 
ENSMUST00000217410.3 Or9g20 ENSMUST00000217410.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2ASV2) A2ASV2 A2ASV2_MOUSE ENSMUST00000217410.1 ENSMUST00000217410.2 Olfr1016 Or9g20 uc289xpo.1 uc289xpo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xpo.1 uc289xpo.2 
ENSMUST00000217413.2 Gm48604 ENSMUST00000217413.2 Gm48604 (from geneSymbol) ENSMUST00000217413.1 LF197545 uc292gnk.1 uc292gnk.2 uc292gnk.1 uc292gnk.2 
ENSMUST00000217414.2 Gm48127 ENSMUST00000217414.2 Gm48127 (from geneSymbol) ENSMUST00000217414.1 uc292gea.1 uc292gea.2 uc292gea.1 uc292gea.2 
ENSMUST00000217419.2 Gm32171 ENSMUST00000217419.2 Gm32171 (from geneSymbol) ENSMUST00000217419.1 uc292fok.1 uc292fok.2 uc292fok.1 uc292fok.2 
ENSMUST00000217423.2 Gm47485 ENSMUST00000217423.2 Gm47485 (from geneSymbol) ENSMUST00000217423.1 uc287qme.1 uc287qme.2 uc287qme.1 uc287qme.2 
ENSMUST00000217425.2 Gm48562 ENSMUST00000217425.2 Gm48562 (from geneSymbol) AK078994 ENSMUST00000217425.1 uc292grs.1 uc292grs.2 uc292grs.1 uc292grs.2 
ENSMUST00000217435.2 Or8j3b ENSMUST00000217435.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR75) ENSMUST00000217435.1 Olfr1057 Or8j3b Q7TR75 Q7TR75_MOUSE uc289xrv.1 uc289xrv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xrv.1 uc289xrv.2 
ENSMUST00000217436.2 Or5w20 ENSMUST00000217436.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1SUW4) A0A1L1SUW4 A0A1L1SUW4_MOUSE ENSMUST00000217436.1 Olfr1153 Or5w20 uc289xwx.1 uc289xwx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xwx.1 uc289xwx.2 
ENSMUST00000217437.2 Or11g26 ENSMUST00000217437.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2RTP5) A2RTP5 A2RTP5_MOUSE AK015132 ENSMUST00000217437.1 Olfr742 Or11g26 uc288tlr.1 uc288tlr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tlr.1 uc288tlr.2 
ENSMUST00000217438.2 Or10d5b ENSMUST00000217438.2 Or10d5b (from geneSymbol) ENSMUST00000217438.1 uc292gcr.1 uc292gcr.2 uc292gcr.1 uc292gcr.2 
ENSMUST00000217440.3 Gm34885 ENSMUST00000217440.3 Gm34885 (from geneSymbol) AK133341 ENSMUST00000217440.1 ENSMUST00000217440.2 uc292fup.1 uc292fup.2 uc292fup.3 uc292fup.1 uc292fup.2 uc292fup.3 
ENSMUST00000217444.4 Ccdc82 ENSMUST00000217444.4 Ccdc82 (from geneSymbol) BC098496 CCD82_MOUSE ENSMUST00000217444.1 ENSMUST00000217444.2 ENSMUST00000217444.3 Q3V462 Q6PG04 uc009shs.1 uc009shs.2 uc009shs.3 uc009shs.4 molecular_function cellular_component biological_process uc009shs.1 uc009shs.2 uc009shs.3 uc009shs.4 
ENSMUST00000217446.2 Gm47416 ENSMUST00000217446.2 Gm47416 (from geneSymbol) ENSMUST00000217446.1 uc292kdr.1 uc292kdr.2 uc292kdr.1 uc292kdr.2 
ENSMUST00000217451.3 Or5b122 ENSMUST00000217451.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEU6) ENSMUST00000217451.1 ENSMUST00000217451.2 Olfr1484 Or5b122 Q8VEU6 Q8VEU6_MOUSE uc289rfv.1 uc289rfv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rfv.1 uc289rfv.2 
ENSMUST00000217460.3 9430081H08Rik ENSMUST00000217460.3 9430081H08Rik (from geneSymbol) AK020500 ENSMUST00000217460.1 ENSMUST00000217460.2 uc292gor.1 uc292gor.2 uc292gor.3 uc292gor.1 uc292gor.2 uc292gor.3 
ENSMUST00000217461.2 Slc44a2 ENSMUST00000217461.2 solute carrier family 44, member 2, transcript variant 3 (from RefSeq NM_001359227.1) CTL2_MOUSE Ctl2 ENSMUST00000217461.1 NM_001359227 Q8BY89 Q8K2F1 uc009okz.1 uc009okz.2 uc009okz.3 uc009okz.4 Choline/H+ antiporter, mainly in mitochodria. Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway. Reaction=choline(out) + n H(+)(in) = choline(in) + n H(+)(out); Xref=Rhea:RHEA:75463, ChEBI:CHEBI:15354, ChEBI:CHEBI:15378; Evidence=; Reaction=ethanolamine(out) + n H(+)(in) = ethanolamine(in) + n H(+)(out); Xref=Rhea:RHEA:75467, ChEBI:CHEBI:15378, ChEBI:CHEBI:57603; Evidence=; Interacts with COCH. Cell membrane ; Multi-pass membrane protein Mitochondrion outer membrane ; Multi-pass membrane protein Note=Mainly expressed in mitochondria. Event=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=CTL2a, CTL2P2; IsoId=Q8BY89-1; Sequence=Displayed; Name=2; Synonyms=CTL2b, CTL2P1; IsoId=Q8BY89-2; Sequence=VSP_015432; Expressed at high levels in lung, colon, inner ear and spleen (at protein level). Progressively lower levels in brain, tongue, liver and kidney (at protein level). In the kidney, prominent expression in glomeruli in the lining of Bowman's capsule and on the mesangial cells adjacent to the vessels within the glomerulus (at protein level). Strongly expressed on the membranes of splenocytes and in lung parenchyme (at protein level). [Isoform 1]: Expressed at higher levels than isoform 2 in colon, heart, kidney, lung, cochlea, tongue and muscle, as well as in the inner ear. [Isoform 2]: Predominantly expressed in brain, liver and spleen. Glycosylated, glycosylation differs from tissue to tissue. The molecular mass of the mature glycosylated protein is highest in kidney, followed by lung, colon and spleen, then brain and tongue. [Isoform 2]: Produced by alternative promoter usage. Belongs to the CTL (choline transporter-like) family. protein binding membrane integral component of membrane uc009okz.1 uc009okz.2 uc009okz.3 uc009okz.4 
ENSMUST00000217466.2 Or52d3 ENSMUST00000217466.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PVA0) E9PVA0 E9PVA0_MOUSE ENSMUST00000217466.1 Olfr653 Or52d3 uc291tuj.1 uc291tuj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tuj.1 uc291tuj.2 
ENSMUST00000217469.2 Or4c109 ENSMUST00000217469.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2ATG3) A2ATG3 A2ATG3_MOUSE ENSMUST00000217469.1 Olfr1214 Or4c109 uc289yad.1 uc289yad.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yad.1 uc289yad.2 
ENSMUST00000217475.2 Cryab ENSMUST00000217475.2 crystallin, alpha B, transcript variant 1 (from RefSeq NM_001289782.1) Cryab ENSMUST00000217475.1 NM_001289782 Q52L78 Q52L78_MOUSE uc009pkl.1 uc009pkl.2 uc009pkl.3 uc009pkl.4 This gene encodes a member of the small heat-shock protein (HSP20) family. The encoded protein is a molecular chaperone that protects proteins against thermal denaturation and other stresses. This protein is a component of the eye lens, regulates lens differentiation and functions as a refractive element in the lens. This protein is a negative regulator of inflammation, has anti-apoptotic properties and also plays a role in the formation of muscular tissue. Mice lacking this gene exhibit worse experimental autoimmune encephalomyelitis and inflammation of the central nervous system compared to the wild type. In mouse models, this gene has a critical role in alleviating the pathology of the neurodegenerative Alexander disease. Mutations in the human gene are associated with myofibrillar myopathy 2, fatal infantile hypertonic myofibrillar myopathy, multiple types of cataract and dilated cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Nucleus Belongs to the small heat shock protein (HSP20) family. beta-amyloid binding structural constituent of eye lens nucleus cytoplasm Golgi apparatus protein folding aging microtubule binding cytoskeletal protein binding cell surface multicellular organism aging regulation of cell death postsynaptic density microtubule cytoskeleton negative regulation of cell growth axon microtubule polymerization or depolymerization negative regulation of protein complex assembly M band I band response to estradiol negative regulation of intracellular transport actin filament bundle macromolecular complex response to hydrogen peroxide identical protein binding protein homodimerization activity negative regulation of apoptotic process dendritic spine perikaryon macromolecular complex binding synapse negative regulation of transcription, DNA-templated metal ion binding protein stabilization unfolded protein binding protein homooligomerization stress-activated MAPK cascade cellular response to gamma radiation synaptic membrane cardiac myofibril negative regulation of reactive oxygen species metabolic process uc009pkl.1 uc009pkl.2 uc009pkl.3 uc009pkl.4 
ENSMUST00000217478.2 Or52b3 ENSMUST00000217478.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q542) E9Q542 E9Q542_MOUSE ENSMUST00000217478.1 Olfr549 Or52b3 uc291tmw.1 uc291tmw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tmw.1 uc291tmw.2 
ENSMUST00000217479.2 Or1n2 ENSMUST00000217479.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGJ8) ENSMUST00000217479.1 Olfr354 Or1n2 Q8VGJ8 Q8VGJ8_MOUSE uc008jmd.1 uc008jmd.2 uc008jmd.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008jmd.1 uc008jmd.2 uc008jmd.3 
ENSMUST00000217480.2 Or1x2 ENSMUST00000217480.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFE6) ENSMUST00000217480.1 Olfr54 Or1x2 Q8VFE6 Q8VFE6_MOUSE uc287xyh.1 uc287xyh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287xyh.1 uc287xyh.2 
ENSMUST00000217481.2 Or8j3c ENSMUST00000217481.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR71) ENSMUST00000217481.1 Olfr1057 Olfr1062 Or8j3c Q7TR71 Q7TR71_MOUSE uc289xsb.1 uc289xsb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xsb.1 uc289xsb.2 
ENSMUST00000217482.2 Or5b116 ENSMUST00000217482.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt F6QVZ8) ENSMUST00000217482.1 F6QVZ8 F6QVZ8_MOUSE Olfr1471 Olfr1480 Or5b116 uc289rey.1 uc289rey.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rey.1 uc289rey.2 
ENSMUST00000217485.2 Or5ac20 ENSMUST00000217485.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGQ3) A0A0J9YVE4 ENSMUST00000217485.1 Olfr202 Or5ac20 Q8VGQ3 Q8VGQ3_MOUSE uc289fgr.1 uc289fgr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289fgr.1 uc289fgr.2 
ENSMUST00000217494.2 Or14a260 ENSMUST00000217494.2 Odorant receptor. (from UniProt Q8VFN8) ENSMUST00000217494.1 Olfr307 Or14a260 Q8VFN8 Q8VFN8_MOUSE uc291sit.1 uc291sit.2 Odorant receptor. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291sit.1 uc291sit.2 
ENSMUST00000217495.2 Gm47050 ENSMUST00000217495.2 Gm47050 (from geneSymbol) AK042214 ENSMUST00000217495.1 uc292mel.1 uc292mel.2 uc292mel.1 uc292mel.2 
ENSMUST00000217506.2 Or5af2 ENSMUST00000217506.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5NC55) ENSMUST00000217506.1 Olfr313 Or5af2 Q5NC55 Q5NC55_MOUSE uc287yle.1 uc287yle.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287yle.1 uc287yle.2 
ENSMUST00000217509.2 Or5t9 ENSMUST00000217509.2 Potential odorant receptor. (from UniProt Q8VF13) ENSMUST00000217509.1 Mor179-7 OR5T9_MOUSE Olfr1094 Or5t9 Q8VF13 uc289xtf.1 uc289xtf.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xtf.1 uc289xtf.2 
ENSMUST00000217517.2 Or8s8 ENSMUST00000217517.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VET6) ENSMUST00000217517.1 Olfr281 Or8s8 Q8VET6 Q8VET6_MOUSE uc007xmn.1 uc007xmn.2 uc007xmn.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc007xmn.1 uc007xmn.2 uc007xmn.3 
ENSMUST00000217519.2 Or2b7 ENSMUST00000217519.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQU0) ENSMUST00000217519.1 Olfr1365 Olfr1535 Or2b7 Q7TQU0 Q7TQU0_MOUSE uc288lff.1 uc288lff.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288lff.1 uc288lff.2 
ENSMUST00000217520.2 Gm48069 ENSMUST00000217520.2 Gm48069 (from geneSymbol) AK080390 ENSMUST00000217520.1 uc292ewu.1 uc292ewu.2 uc292ewu.1 uc292ewu.2 
ENSMUST00000217522.3 Or13p5 ENSMUST00000217522.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGB1) ENSMUST00000217522.1 ENSMUST00000217522.2 Olfr1339 Olfr62 Or13p5 Q8VGB1 Q8VGB1_MOUSE uc290pio.1 uc290pio.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc290pio.1 uc290pio.2 
ENSMUST00000217526.2 Or52i2 ENSMUST00000217526.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q549) E9Q549 E9Q549_MOUSE ENSMUST00000217526.1 Olfr556 Or52i2 uc291tnj.1 uc291tnj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tnj.1 uc291tnj.2 
ENSMUST00000217527.2 Gm47677 ENSMUST00000217527.2 Gm47677 (from geneSymbol) ENSMUST00000217527.1 uc292fkz.1 uc292fkz.2 uc292fkz.1 uc292fkz.2 
ENSMUST00000217535.3 Gm48249 ENSMUST00000217535.3 Gm48249 (from geneSymbol) AK043723 ENSMUST00000217535.1 ENSMUST00000217535.2 uc007ens.1 uc007ens.2 uc007ens.3 uc007ens.4 uc007ens.1 uc007ens.2 uc007ens.3 uc007ens.4 
ENSMUST00000217536.3 Or4d5 ENSMUST00000217536.3 Membrane ; Multi- pass membrane protein (from UniProt Q8VFN1) ENSMUST00000217536.1 ENSMUST00000217536.2 Olfr984 Or4d5 Q8VFN1 Q8VFN1_MOUSE uc292gdd.1 uc292gdd.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gdd.1 uc292gdd.2 
ENSMUST00000217540.2 Gm47234 ENSMUST00000217540.2 Gm47234 (from geneSymbol) ENSMUST00000217540.1 LF197555 uc292gqu.1 uc292gqu.2 uc292gqu.1 uc292gqu.2 
ENSMUST00000217557.3 Gm47262 ENSMUST00000217557.3 Gm47262 (from geneSymbol) ENSMUST00000217557.1 ENSMUST00000217557.2 uc292hyz.1 uc292hyz.2 uc292hyz.3 uc292hyz.1 uc292hyz.2 uc292hyz.3 
ENSMUST00000217559.3 Gm47927 ENSMUST00000217559.3 Gm47927 (from geneSymbol) ENSMUST00000217559.1 ENSMUST00000217559.2 uc287qww.1 uc287qww.2 uc287qww.3 uc287qww.1 uc287qww.2 uc287qww.3 
ENSMUST00000217561.2 Gm47233 ENSMUST00000217561.2 Gm47233 (from geneSymbol) AB345282 ENSMUST00000217561.1 uc292ilq.1 uc292ilq.2 uc292ilq.1 uc292ilq.2 
ENSMUST00000217570.2 Adpgk ENSMUST00000217570.2 ADP-dependent glucokinase, transcript variant 1 (from RefSeq NM_028121.2) A0A1L1SSF2 A0A1L1SSF2_MOUSE Adpgk ENSMUST00000217570.1 NM_028121 uc009pxp.1 uc009pxp.2 uc009pxp.3 endoplasmic reticulum carbohydrate metabolic process glucose metabolic process phosphorylation phosphotransferase activity, alcohol group as acceptor ADP-specific glucokinase activity uc009pxp.1 uc009pxp.2 uc009pxp.3 
ENSMUST00000217571.2 Or6c215 ENSMUST00000217571.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFI1) ENSMUST00000217571.1 Olfr811 Or6c215 Q8VFI1 Q8VFI1_MOUSE uc287vzn.1 uc287vzn.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vzn.1 uc287vzn.2 
ENSMUST00000217574.2 Gm48346 ENSMUST00000217574.2 Gm48346 (from geneSymbol) AK048883 ENSMUST00000217574.1 uc292hhv.1 uc292hhv.2 uc292hhv.1 uc292hhv.2 
ENSMUST00000217575.3 Or5d38 ENSMUST00000217575.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR27) ENSMUST00000217575.1 ENSMUST00000217575.2 Olfr1166 Or5d38 Q7TR27 Q7TR27_MOUSE uc008kpk.1 uc008kpk.2 uc008kpk.3 uc008kpk.4 uc008kpk.5 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kpk.1 uc008kpk.2 uc008kpk.3 uc008kpk.4 uc008kpk.5 
ENSMUST00000217576.2 Or6c1 ENSMUST00000217576.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGJ2) ENSMUST00000217576.1 Olfr786 Olfr802 Or6c1 Q8VGJ2 Q8VGJ2_MOUSE uc287vys.1 uc287vys.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287vys.1 uc287vys.2 
ENSMUST00000217577.2 Or10n7-ps1 ENSMUST00000217577.2 Or10n7-ps1 (from geneSymbol) ENSMUST00000217577.1 NR_190801 uc292gbw.1 uc292gbw.2 uc292gbw.1 uc292gbw.2 
ENSMUST00000217582.2 Gm47687 ENSMUST00000217582.2 Gm47687 (from geneSymbol) ENSMUST00000217582.1 uc287qjs.1 uc287qjs.2 uc287qjs.1 uc287qjs.2 
ENSMUST00000217586.3 Or8k27 ENSMUST00000217586.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR70) ENSMUST00000217586.1 ENSMUST00000217586.2 Olfr1065 Or8k27 Q7TR70 Q7TR70_MOUSE uc289xsg.1 uc289xsg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xsg.1 uc289xsg.2 
ENSMUST00000217588.3 Or4a67 ENSMUST00000217588.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2ATJ4) A2ATJ4 A2ATJ4_MOUSE ENSMUST00000217588.1 ENSMUST00000217588.2 Olfr1200 Or4a67 uc289xzm.1 uc289xzm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xzm.1 uc289xzm.2 
ENSMUST00000217590.2 Or12d2 ENSMUST00000217590.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt B2RT33) B2RT33 B2RT33_MOUSE ENSMUST00000217590.1 Olfr102 Or12d2 uc289kyz.1 uc289kyz.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kyz.1 uc289kyz.2 
ENSMUST00000217600.2 Or10g7 ENSMUST00000217600.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q985) E9Q985 E9Q985_MOUSE ENSMUST00000217600.1 Olfr978 Or10g7 uc292gcs.1 uc292gcs.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gcs.1 uc292gcs.2 
ENSMUST00000217609.2 Gm47877 ENSMUST00000217609.2 Gm47877 (from geneSymbol) ENSMUST00000217609.1 uc292hjl.1 uc292hjl.2 uc292hjl.1 uc292hjl.2 
ENSMUST00000217611.2 Or4k42 ENSMUST00000217611.2 olfactory receptor family 4 subfamily K member 42, transcript variant 1 (from RefSeq NM_146262.3) ENSMUST00000217611.1 NM_146262 Olfr1290 Or4k42 Q7TQX8 Q7TQX8_MOUSE uc033hpc.1 uc033hpc.2 uc033hpc.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033hpc.1 uc033hpc.2 uc033hpc.3 
ENSMUST00000217616.3 Or5p73 ENSMUST00000217616.3 olfactory receptor family 5 subfamily P member 73 (from RefSeq NM_146307.2) A0A0R4J0X9 ENSMUST00000217616.1 ENSMUST00000217616.2 Mor204-36 NM_146307 O5P73_MOUSE Olfr498 Or5p73 Q8VEW2 uc009jcl.1 uc009jcl.2 uc009jcl.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009jcl.1 uc009jcl.2 uc009jcl.3 
ENSMUST00000217617.2 Or10q3 ENSMUST00000217617.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQS2) ENSMUST00000217617.1 Olfr1419 Or10q3 Q7TQS2 Q7TQS2_MOUSE uc008gtf.1 uc008gtf.2 uc008gtf.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gtf.1 uc008gtf.2 uc008gtf.3 
ENSMUST00000217618.3 Or5p53 ENSMUST00000217618.3 Potential odorant receptor. (from UniProt Q8VG44) ENSMUST00000217618.1 ENSMUST00000217618.2 Mor204-4 O5P53_MOUSE Olfr473 Or5p53 Q8VG44 uc291ufs.1 uc291ufs.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ufs.1 uc291ufs.2 
ENSMUST00000217619.2 Gm48183 ENSMUST00000217619.2 Gm48183 (from geneSymbol) ENSMUST00000217619.1 uc290fvv.1 uc290fvv.2 uc290fvv.1 uc290fvv.2 
ENSMUST00000217623.2 Gm36367 ENSMUST00000217623.2 Gm36367 (from geneSymbol) AK043602 ENSMUST00000217623.1 uc292lwk.1 uc292lwk.2 uc292lwk.1 uc292lwk.2 
ENSMUST00000217627.2 Or51ag1 ENSMUST00000217627.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q598) E9Q598 E9Q598_MOUSE ENSMUST00000217627.1 Olfr610 Or51ag1 uc291tqq.1 uc291tqq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tqq.1 uc291tqq.2 
ENSMUST00000217629.2 Gm48273 ENSMUST00000217629.2 Gm48273 (from geneSymbol) ENSMUST00000217629.1 LF307311 uc287rbn.1 uc287rbn.2 uc287rbn.1 uc287rbn.2 
ENSMUST00000217635.2 Or4c116 ENSMUST00000217635.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7MU53) ENSMUST00000217635.1 L7MU53 L7MU53_MOUSE Olfr1221 Or4c116 uc289yav.1 uc289yav.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289yav.1 uc289yav.2 
ENSMUST00000217642.2 Or2t6 ENSMUST00000217642.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF37) A0A0U1RPU9 ENSMUST00000217642.1 Olfr720 Or2t6 Q8VF37 Q8VF37_MOUSE uc288qws.1 uc288qws.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288qws.1 uc288qws.2 
ENSMUST00000217646.2 Ankdd1a ENSMUST00000217646.2 ankyrin repeat and death domain containing 1A (from RefSeq NM_001370871.1) A0A1L1ST07 A0A1L1ST07_MOUSE Ankdd1a ENSMUST00000217646.1 NM_001370871 uc292ifk.1 uc292ifk.2 molecular_function cellular_component signal transduction biological_process uc292ifk.1 uc292ifk.2 
ENSMUST00000217650.2 Or5j1 ENSMUST00000217650.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR57) ENSMUST00000217650.1 Olfr1106 Or5j1 Q7TR57 Q7TR57_MOUSE uc289xts.1 uc289xts.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xts.1 uc289xts.2 
ENSMUST00000217651.3 Mmp1a ENSMUST00000217651.3 matrix metallopeptidase 1a (interstitial collagenase) (from RefSeq NM_032006.3) ENSMUST00000217651.1 ENSMUST00000217651.2 MMP1A_MOUSE McolA NM_032006 Q149J4 Q9EPL5 uc292eij.1 uc292eij.2 This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens. Mice lacking the encoded protein exhibit decreased susceptibility to chemical carcinogen-induced lung tumor development and angiogenesis. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC117756.2, AK049552.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (By similarity). Able to degrade synthetic peptides and type I and II fibrillar collagen. Reaction=Cleavage of the triple helix of collagen at about three- quarters of the length of the molecule from the N-terminus, at 775- Gly-|-Ile-776 in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.; EC=3.4.24.7; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence=; Note=Binds 4 Ca(2+) ions per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Can be activated without removal of the activation peptide. Secreted, extracellular space, extracellular matrix The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. Belongs to the peptidase M10A family. metalloendopeptidase activity extracellular region proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix metal ion binding uc292eij.1 uc292eij.2 
ENSMUST00000217653.3 Or5p57 ENSMUST00000217653.3 olfactory receptor family 5 subfamily P member 57 (from RefSeq NM_020291.2) ENSMUST00000217653.1 ENSMUST00000217653.2 Mor204-32 NM_020291 O5P87_MOUSE Olfr480 Or5p57 Q8VEZ0 Q9WU91 uc291uga.1 uc291uga.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Probable odorant receptor, which recognizes only aliphatic alcohols, suggesting that it may convey a 'woody' or 'sweet' sour. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Sequence=AAD27597.1; Type=Erroneous initiation; Evidence=; G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uga.1 uc291uga.2 
ENSMUST00000217654.2 Gm48796 ENSMUST00000217654.2 Gm48796 (from geneSymbol) AK039971 ENSMUST00000217654.1 uc292fjo.1 uc292fjo.2 uc292fjo.1 uc292fjo.2 
ENSMUST00000217661.2 Spata31h1 ENSMUST00000217661.2 Spata31h1 (from geneSymbol) 4932415D10Rik A0A1W2P6U8 A0A1W2P6U8_MOUSE ENSMUST00000217661.1 uc287tnq.1 uc287tnq.2 molecular_function biological_process membrane integral component of membrane uc287tnq.1 uc287tnq.2 
ENSMUST00000217666.2 Gm10165 ENSMUST00000217666.2 Gm10165 (from geneSymbol) AY512922 ENSMUST00000217666.1 uc288gdd.1 uc288gdd.2 uc288gdd.1 uc288gdd.2 
ENSMUST00000217680.2 Gm5427 ENSMUST00000217680.2 Gm5427 (from geneSymbol) AK076335 ENSMUST00000217680.1 uc287ukj.1 uc287ukj.2 uc287ukj.1 uc287ukj.2 
ENSMUST00000217695.3 Gm47710 ENSMUST00000217695.3 Gm47710 (from geneSymbol) AK035829 ENSMUST00000217695.1 ENSMUST00000217695.2 uc007elq.1 uc007elq.2 uc007elq.3 uc007elq.4 uc007elq.1 uc007elq.2 uc007elq.3 uc007elq.4 
ENSMUST00000217696.3 Gm47614 ENSMUST00000217696.3 Gm47614 (from geneSymbol) ENSMUST00000217696.1 ENSMUST00000217696.2 uc287rds.1 uc287rds.2 uc287rds.3 uc287rds.1 uc287rds.2 uc287rds.3 
ENSMUST00000217701.2 Or2f2 ENSMUST00000217701.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRV8) ENSMUST00000217701.1 Olfr452 Or2f2 Q7TRV8 Q7TRV8_MOUSE uc291dyx.1 uc291dyx.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dyx.1 uc291dyx.2 
ENSMUST00000217704.2 Gm47911 ENSMUST00000217704.2 Gm47911 (from geneSymbol) ENSMUST00000217704.1 uc287qkx.1 uc287qkx.2 uc287qkx.1 uc287qkx.2 
ENSMUST00000217707.2 Gm48281 ENSMUST00000217707.2 Gm48281 (from geneSymbol) ENSMUST00000217707.1 uc287pmg.1 uc287pmg.2 uc287pmg.1 uc287pmg.2 
ENSMUST00000217709.2 Gm35274 ENSMUST00000217709.2 Gm35274 (from geneSymbol) ENSMUST00000217709.1 uc288ilk.1 uc288ilk.2 uc288ilk.1 uc288ilk.2 
ENSMUST00000217715.2 Gm47571 ENSMUST00000217715.2 Gm47571 (from geneSymbol) ENSMUST00000217715.1 uc287raa.1 uc287raa.2 uc287raa.1 uc287raa.2 
ENSMUST00000217724.2 Or14c46 ENSMUST00000217724.2 Odorant receptor. (from UniProt B2RVZ1) B2RVZ1 B2RVZ1_MOUSE ENSMUST00000217724.1 Olfr310 Or14c46 uc291sin.1 uc291sin.2 Odorant receptor. Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291sin.1 uc291sin.2 
ENSMUST00000217731.3 Gm31181 ENSMUST00000217731.3 predicted gene, 31181 (from RefSeq NR_188948.1) ENSMUST00000217731.1 ENSMUST00000217731.2 NR_188948 uc287rup.1 uc287rup.2 uc287rup.3 uc287rup.1 uc287rup.2 uc287rup.3 
ENSMUST00000217732.2 Gm47030 ENSMUST00000217732.2 Gm47030 (from geneSymbol) ENSMUST00000217732.1 uc288gda.1 uc288gda.2 uc288gda.1 uc288gda.2 
ENSMUST00000217734.2 Or2ag15 ENSMUST00000217734.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFM4) ENSMUST00000217734.1 Olfr697 Or2ag15 Q8VFM4 Q8VFM4_MOUSE uc291ucn.1 uc291ucn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ucn.1 uc291ucn.2 
ENSMUST00000217736.2 4933436P19Rik ENSMUST00000217736.2 4933436P19Rik (from geneSymbol) AK017091 ENSMUST00000217736.1 uc287spq.1 uc287spq.2 uc287spq.1 uc287spq.2 
ENSMUST00000217739.2 Or2ag2b ENSMUST00000217739.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9D3U9) AK016560 ENSMUST00000217739.1 Olfr701 Or2ag2b Q9D3U9 Q9D3U9_MOUSE uc291ucu.1 uc291ucu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ucu.1 uc291ucu.2 
ENSMUST00000217740.2 D830039M14Rik ENSMUST00000217740.2 D830039M14Rik (from geneSymbol) ENSMUST00000217740.1 uc007fgb.1 uc007fgb.2 uc007fgb.3 uc007fgb.1 uc007fgb.2 uc007fgb.3 
ENSMUST00000217743.2 Gm48752 ENSMUST00000217743.2 Gm48752 (from geneSymbol) ENSMUST00000217743.1 uc287txp.1 uc287txp.2 uc287txp.1 uc287txp.2 
ENSMUST00000217744.2 Gm48518 ENSMUST00000217744.2 Gm48518 (from geneSymbol) ENSMUST00000217744.1 LF199142 uc288gew.1 uc288gew.2 uc288gew.1 uc288gew.2 
ENSMUST00000217752.2 Gm47865 ENSMUST00000217752.2 Gm47865 (from geneSymbol) ENSMUST00000217752.1 uc287uvq.1 uc287uvq.2 uc287uvq.1 uc287uvq.2 
ENSMUST00000217761.2 Gm48053 ENSMUST00000217761.2 Gm48053 (from geneSymbol) AK145256 ENSMUST00000217761.1 uc287rhw.1 uc287rhw.2 uc287rhw.1 uc287rhw.2 
ENSMUST00000217762.2 Gm48655 ENSMUST00000217762.2 Gm48655 (from geneSymbol) ENSMUST00000217762.1 uc288glt.1 uc288glt.2 uc288glt.1 uc288glt.2 
ENSMUST00000217771.2 Gm48697 ENSMUST00000217771.2 Gm48697 (from geneSymbol) ENSMUST00000217771.1 uc287pob.1 uc287pob.2 uc287pob.1 uc287pob.2 
ENSMUST00000217772.2 Or4k45 ENSMUST00000217772.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF48) ENSMUST00000217772.1 Olfr1295 Olfr1297 Or4k45 Q8VF48 Q8VF48_MOUSE uc008lns.1 uc008lns.2 uc008lns.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008lns.1 uc008lns.2 uc008lns.3 
ENSMUST00000217778.2 A830082N09Rik ENSMUST00000217778.2 A830082N09Rik (from geneSymbol) ENSMUST00000217778.1 uc287qlq.1 uc287qlq.2 uc287qlq.1 uc287qlq.2 
ENSMUST00000217783.2 Gm47897 ENSMUST00000217783.2 Gm47897 (from geneSymbol) ENSMUST00000217783.1 uc287rut.1 uc287rut.2 uc287rut.1 uc287rut.2 
ENSMUST00000217786.2 Gm47397 ENSMUST00000217786.2 Gm47397 (from geneSymbol) ENSMUST00000217786.1 uc288ile.1 uc288ile.2 uc288ile.1 uc288ile.2 
ENSMUST00000217790.2 Gm47840 ENSMUST00000217790.2 Gm47840 (from geneSymbol) ENSMUST00000217790.1 uc287vjn.1 uc287vjn.2 uc287vjn.1 uc287vjn.2 
ENSMUST00000217799.3 Gm10747 ENSMUST00000217799.3 Gm10747 (from geneSymbol) AK145303 ENSMUST00000217799.1 ENSMUST00000217799.2 uc007hcq.1 uc007hcq.2 uc007hcq.3 uc007hcq.1 uc007hcq.2 uc007hcq.3 
ENSMUST00000217800.2 Gm47252 ENSMUST00000217800.2 Gm47252 (from geneSymbol) ENSMUST00000217800.1 uc290squ.1 uc290squ.2 uc290squ.1 uc290squ.2 
ENSMUST00000217803.2 Or10a3 ENSMUST00000217803.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VEW1) ENSMUST00000217803.1 Olfr518 Or10a3 Q8VEW1 Q8VEW1_MOUSE uc291uhy.1 uc291uhy.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291uhy.1 uc291uhy.2 
ENSMUST00000217812.2 Hamp2 ENSMUST00000217812.2 Secreted (from UniProt Q5M9M1) BC086895 ENSMUST00000217812.1 Hamp2 Q5M9M1 Q5M9M1_MOUSE uc009ghd.1 uc009ghd.2 uc009ghd.3 Secreted Belongs to the hepcidin family. extracellular region cell cellular iron ion homeostasis uc009ghd.1 uc009ghd.2 uc009ghd.3 
ENSMUST00000217814.3 Gm47671 ENSMUST00000217814.3 Gm47671 (from geneSymbol) AK133077 ENSMUST00000217814.1 ENSMUST00000217814.2 uc287uil.1 uc287uil.2 uc287uil.3 uc287uil.1 uc287uil.2 uc287uil.3 
ENSMUST00000217818.2 Gm48332 ENSMUST00000217818.2 Gm48332 (from geneSymbol) ENSMUST00000217818.1 uc287rby.1 uc287rby.2 uc287rby.1 uc287rby.2 
ENSMUST00000217821.2 Gm48181 ENSMUST00000217821.2 Gm48181 (from geneSymbol) ENSMUST00000217821.1 uc288gdu.1 uc288gdu.2 uc288gdu.1 uc288gdu.2 
ENSMUST00000217825.2 Gm40778 ENSMUST00000217825.2 Gm40778 (from geneSymbol) AK047960 ENSMUST00000217825.1 uc287vdr.1 uc287vdr.2 uc287vdr.1 uc287vdr.2 
ENSMUST00000217837.2 Cfd ENSMUST00000217837.2 complement factor D, transcript variant 2 (from RefSeq NM_001291915.2) Adn CFAD_MOUSE Df ENSMUST00000217837.1 NM_001291915 P03953 Q61280 uc011xif.1 uc011xif.2 uc011xif.3 uc011xif.4 This gene encodes a serine protease that plays an important role in the alternative pathway of complement activation for pathogen recognition and elimination. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that in turn cleaves factor B in the complement pathway. This gene is expressed in adipocytes and the mature enzyme is secreted into the bloodstream. Mice lacking the encoded product cannot initiate alternative pathway of complement activation. [provided by RefSeq, Jul 2016]. Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Reaction=Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.; EC=3.4.21.46; Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P03953-1; Sequence=Displayed; Name=2; IsoId=P03953-2; Sequence=VSP_005382; N-glycosylated. Belongs to the peptidase S1 family. immune system process endopeptidase activity serine-type endopeptidase activity extracellular region extracellular space proteolysis complement activation, alternative pathway Notch signaling pathway peptidase activity serine-type peptidase activity response to bacterium hydrolase activity innate immune response uc011xif.1 uc011xif.2 uc011xif.3 uc011xif.4 
ENSMUST00000217838.2 Pcnt ENSMUST00000217838.2 pericentrin (kendrin), transcript variant 2 (from RefSeq NM_001282992.2) A0A1W2P737 A0A1W2P737_MOUSE ENSMUST00000217838.1 NM_001282992 Pcnt uc007ful.1 uc007ful.2 uc007ful.3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome signal transduction binding, bridging uc007ful.1 uc007ful.2 uc007ful.3 
ENSMUST00000217845.3 Or4f17-ps1 ENSMUST00000217845.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1L1SVB5) A0A1L1SVB5 A0A1L1SVB5_MOUSE ENSMUST00000217845.1 ENSMUST00000217845.2 Or4f17-ps1 uc289zff.1 uc289zff.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zff.1 uc289zff.2 
ENSMUST00000217854.2 Ppfia2 ENSMUST00000217854.2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2, transcript variant 28 (from RefSeq NM_001359697.1) B8QI34 B8QI34_MOUSE ENSMUST00000217854.1 NM_001359697 Ppfia2 ppfia2 uc007gys.1 uc007gys.2 uc007gys.3 uc007gys.4 Belongs to the liprin family. Liprin-alpha subfamily. synapse glutamatergic synapse regulation of synaptic vesicle exocytosis uc007gys.1 uc007gys.2 uc007gys.3 uc007gys.4 
ENSMUST00000217855.2 Gm48207 ENSMUST00000217855.2 Gm48207 (from geneSymbol) AK047019 ENSMUST00000217855.1 uc287uri.1 uc287uri.2 uc287uri.1 uc287uri.2 
ENSMUST00000217867.2 Gm48036 ENSMUST00000217867.2 Gm48036 (from geneSymbol) ENSMUST00000217867.1 uc287sap.1 uc287sap.2 uc287sap.1 uc287sap.2 
ENSMUST00000217880.3 Gm32443 ENSMUST00000217880.3 Gm32443 (from geneSymbol) ENSMUST00000217880.1 ENSMUST00000217880.2 uc288fst.1 uc288fst.2 uc288fst.3 uc288fst.1 uc288fst.2 uc288fst.3 
ENSMUST00000217882.3 Gm48678 ENSMUST00000217882.3 Gm48678 (from geneSymbol) AK038753 ENSMUST00000217882.1 ENSMUST00000217882.2 uc288era.1 uc288era.2 uc288era.3 uc288era.1 uc288era.2 uc288era.3 
ENSMUST00000217888.2 Gm48015 ENSMUST00000217888.2 Gm48015 (from geneSymbol) AK046938 ENSMUST00000217888.1 uc288iky.1 uc288iky.2 uc288iky.1 uc288iky.2 
ENSMUST00000217893.3 Gm48089 ENSMUST00000217893.3 Gm48089 (from geneSymbol) ENSMUST00000217893.1 ENSMUST00000217893.2 uc287ulm.1 uc287ulm.2 uc287ulm.3 uc287ulm.1 uc287ulm.2 uc287ulm.3 
ENSMUST00000217904.2 Gm47018 ENSMUST00000217904.2 Gm47018 (from geneSymbol) AK043795 ENSMUST00000217904.1 uc287raz.1 uc287raz.2 uc287raz.1 uc287raz.2 
ENSMUST00000217909.2 Gm47839 ENSMUST00000217909.2 Gm47839 (from geneSymbol) ENSMUST00000217909.1 uc287vjm.1 uc287vjm.2 uc287vjm.1 uc287vjm.2 
ENSMUST00000217920.2 Gm47761 ENSMUST00000217920.2 Gm47761 (from geneSymbol) ENSMUST00000217920.1 uc287pta.1 uc287pta.2 uc287pta.1 uc287pta.2 
ENSMUST00000217935.2 Gm48410 ENSMUST00000217935.2 Gm48410 (from geneSymbol) AK136356 ENSMUST00000217935.1 uc287vfv.1 uc287vfv.2 uc287vfv.1 uc287vfv.2 
ENSMUST00000217945.2 Gm35206 ENSMUST00000217945.2 predicted gene, 35206 (from RefSeq NR_155868.1) ENSMUST00000217945.1 NR_155868 uc287ulz.1 uc287ulz.2 uc287ulz.1 uc287ulz.2 
ENSMUST00000217947.2 Gm47015 ENSMUST00000217947.2 Gm47015 (from geneSymbol) ENSMUST00000217947.1 uc287srn.1 uc287srn.2 uc287srn.1 uc287srn.2 
ENSMUST00000217950.2 4933411E08Rik ENSMUST00000217950.2 RIKEN cDNA 4933411E08 gene (from RefSeq NR_045342.1) ENSMUST00000217950.1 NR_045342 uc029rfv.1 uc029rfv.2 uc029rfv.3 uc029rfv.1 uc029rfv.2 uc029rfv.3 
ENSMUST00000217951.2 Gm48535 ENSMUST00000217951.2 Gm48535 (from geneSymbol) ENSMUST00000217951.1 uc288gfc.1 uc288gfc.2 uc288gfc.1 uc288gfc.2 
ENSMUST00000217953.2 Gm47903 ENSMUST00000217953.2 Gm47903 (from geneSymbol) ENSMUST00000217953.1 uc287ruv.1 uc287ruv.2 uc287ruv.1 uc287ruv.2 
ENSMUST00000217955.2 Gm47615 ENSMUST00000217955.2 Gm47615 (from geneSymbol) AK084313 ENSMUST00000217955.1 uc287rtd.1 uc287rtd.2 uc287rtd.1 uc287rtd.2 
ENSMUST00000217956.2 A730063M14Rik ENSMUST00000217956.2 A730063M14Rik (from geneSymbol) AK080508 ENSMUST00000217956.1 uc287vll.1 uc287vll.2 uc287vll.1 uc287vll.2 
ENSMUST00000217963.3 Gm48759 ENSMUST00000217963.3 Gm48759 (from geneSymbol) ENSMUST00000217963.1 ENSMUST00000217963.2 uc287plm.1 uc287plm.2 uc287plm.3 uc287plm.1 uc287plm.2 uc287plm.3 
ENSMUST00000217965.2 Gm48512 ENSMUST00000217965.2 Gm48512 (from geneSymbol) ENSMUST00000217965.1 uc288enm.1 uc288enm.2 uc288enm.1 uc288enm.2 
ENSMUST00000217967.2 Gm48898 ENSMUST00000217967.2 Gm48898 (from geneSymbol) AK050947 ENSMUST00000217967.1 uc288eub.1 uc288eub.2 uc288eub.1 uc288eub.2 
ENSMUST00000217974.2 Kcns3 ENSMUST00000217974.2 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3, transcript variant 5 (from RefSeq NM_001413256.1) ENSMUST00000217974.1 KCNS3_MOUSE NM_001413256 Q8BQZ8 uc033gcr.1 uc033gcr.2 uc033gcr.3 Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells. Heterotetramer with KCNB1. Does not form homomultimers. Cell membrane ; Multi-pass membrane protein Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1. The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily. ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity potassium channel activity Golgi apparatus cytosol plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex membrane integral component of membrane regulation of ion transmembrane transport protein homooligomerization transmembrane transport potassium ion transmembrane transport uc033gcr.1 uc033gcr.2 uc033gcr.3 
ENSMUST00000217978.2 Or10ac1 ENSMUST00000217978.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A0B4J1M2) A0A0B4J1M2 A0A0B4J1M2_MOUSE ENSMUST00000217978.1 Olfr455 Or10ac1 uc291dyi.1 uc291dyi.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dyi.1 uc291dyi.2 
ENSMUST00000217986.2 Gm48225 ENSMUST00000217986.2 Gm48225 (from geneSymbol) ENSMUST00000217986.1 uc288hjo.1 uc288hjo.2 uc288hjo.1 uc288hjo.2 
ENSMUST00000218004.2 Xpot ENSMUST00000218004.2 exportin, tRNA (nuclear export receptor for tRNAs), transcript variant 4 (from RefSeq NM_001401045.1) A0A1W2P7Q6 A0A1W2P7Q6_MOUSE ENSMUST00000218004.1 NM_001401045 Xpot uc007hfv.1 uc007hfv.2 uc007hfv.3 tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Cytoplasm cleus Note=Shuttles between the nucleus and the cytoplasm. Belongs to the exportin family. tRNA binding RNA binding nucleus cytoplasm tRNA export from nucleus intracellular protein transport Ran GTPase binding tRNA re-export from nucleus uc007hfv.1 uc007hfv.2 uc007hfv.3 
ENSMUST00000218006.2 Gm40689 ENSMUST00000218006.2 Gm40689 (from geneSymbol) ENSMUST00000218006.1 uc287saj.1 uc287saj.2 uc287saj.1 uc287saj.2 
ENSMUST00000218020.2 C1s2 ENSMUST00000218020.2 complement component 1, s subcomponent 2 (from RefSeq NM_173864.2) A0A1W2P7F1 A0A1W2P7F1_MOUSE C1s2 ENSMUST00000218020.1 NM_173864 uc009dre.1 uc009dre.2 The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase activity calcium ion binding proteolysis complement activation, classical pathway peptidase activity hydrolase activity uc009dre.1 uc009dre.2 
ENSMUST00000218023.2 Brcc3dc ENSMUST00000218023.2 BRCA1/BRCA2-containing complex, subunit 3, domain containing (from RefSeq NM_203660.2) BRC3L_MOUSE C6.1al ENSMUST00000218023.1 Gm5136 NM_203660 Q3UY45 Q7M757 uc007gzj.1 uc007gzj.2 uc007gzj.3 uc007gzj.4 Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Belongs to the peptidase M67A family. BRCC36 subfamily. thiol-dependent ubiquitin-specific protease activity nucleus DNA repair double-strand break repair proteolysis peptidase activity metallopeptidase activity response to ionizing radiation hydrolase activity polyubiquitin binding thiol-dependent ubiquitinyl hydrolase activity positive regulation of DNA repair metal ion binding BRCA1-A complex protein K63-linked deubiquitination histone H2A K63-linked deubiquitination BRISC complex signal transduction involved in G2 DNA damage checkpoint uc007gzj.1 uc007gzj.2 uc007gzj.3 uc007gzj.4 
ENSMUST00000218027.2 Gm48772 ENSMUST00000218027.2 Gm48772 (from geneSymbol) AK050907 ENSMUST00000218027.1 uc287vay.1 uc287vay.2 uc287vay.1 uc287vay.2 
ENSMUST00000218033.2 Gm47690 ENSMUST00000218033.2 Gm47690 (from geneSymbol) AK141868 ENSMUST00000218033.1 uc288hfs.1 uc288hfs.2 uc288hfs.1 uc288hfs.2 
ENSMUST00000218037.2 Gm48307 ENSMUST00000218037.2 Gm48307 (from geneSymbol) ENSMUST00000218037.1 uc287twc.1 uc287twc.2 uc287twc.1 uc287twc.2 
ENSMUST00000218041.2 Gm48230 ENSMUST00000218041.2 Gm48230 (from geneSymbol) ENSMUST00000218041.1 uc288hjr.1 uc288hjr.2 uc288hjr.1 uc288hjr.2 
ENSMUST00000218046.2 ENSMUSG00000121296 ENSMUST00000218046.2 ENSMUSG00000121296 (from geneSymbol) ENSMUST00000218046.1 uc291txf.1 uc291txf.2 uc291txf.1 uc291txf.2 
ENSMUST00000218053.2 Gm47339 ENSMUST00000218053.2 Gm47339 (from geneSymbol) ENSMUST00000218053.1 uc287utt.1 uc287utt.2 uc287utt.1 uc287utt.2 
ENSMUST00000218054.3 Eif1ad15 ENSMUST00000218054.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. (from UniProt J3QNT6) A0A1W2P883 ENSMUST00000218054.1 ENSMUST00000218054.2 Eif1ad15 J3QNT6 J3QNT6_MOUSE uc007ojt.1 uc007ojt.2 uc007ojt.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. RNA binding translation initiation factor activity translation translational initiation uc007ojt.1 uc007ojt.2 uc007ojt.3 
ENSMUST00000218055.2 Zup1 ENSMUST00000218055.2 zinc finger containing ubiquitin peptidase 1, transcript variant 4 (from RefSeq NR_153113.1) ENSMUST00000218055.1 NR_153113 Q3T9Z9 Q5FWB1 Q6NXI1 Q8BJZ1 Q8BK40 Q8BKH3 Q8BL75 Q9CSP5 ZUP1_MOUSE Zufsp Zup1 uc007euk.1 uc007euk.2 uc007euk.3 Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; Interacts with RPA1 and RPA2. Cytoplasm Nucleus Note=Mostly present in the nuclear fraction. Localizes to DNA lesions. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3T9Z9-1; Sequence=Displayed; Name=2; IsoId=Q3T9Z9-2; Sequence=VSP_019537; Name=3; IsoId=Q3T9Z9-3; Sequence=VSP_019536; Name=4; IsoId=Q3T9Z9-4; Sequence=VSP_019534, VSP_019535; The motif interacting with ubiquitin (MIU) and ZUFSP ubiquitin- binding domain (zUBD, also called ZUFSP helical arm ZHA) are responsible for binding the distal (outgoing) ubiquitin units S1 and S2 respectively. C2H2-type zinc finger 4 is a ubiquitin-binding zinc finger (UBZ) and required for polyubiquitin binding, possibly binding the proximal ubiqutin, and for catalytic activity. C2H2-type zinc fingers 1-3 are required for localization to sites of DNA damage. Belongs to the peptidase C78 family. ZUFSP subfamily. Sequence=BAC36984.1; Type=Frameshift; Evidence=; nucleic acid binding nucleus cytoplasm proteolysis biological_process hydrolase activity thiol-dependent ubiquitinyl hydrolase activity metal ion binding uc007euk.1 uc007euk.2 uc007euk.3 
ENSMUST00000218063.2 Gm6653 ENSMUST00000218063.2 Gm6653 (from geneSymbol) AK132809 ENSMUST00000218063.1 uc287twh.1 uc287twh.2 uc287twh.1 uc287twh.2 
ENSMUST00000218065.2 Or4f53 ENSMUST00000218065.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF40) ENSMUST00000218065.1 Olfr1276 Or4f53 Q8VF40 Q8VF40_MOUSE uc289zee.1 uc289zee.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289zee.1 uc289zee.2 
ENSMUST00000218068.2 Gm47026 ENSMUST00000218068.2 Gm47026 (from geneSymbol) AK035630 ENSMUST00000218068.1 uc287vdz.1 uc287vdz.2 uc287vdz.1 uc287vdz.2 
ENSMUST00000218069.2 Gm48792 ENSMUST00000218069.2 Gm48792 (from geneSymbol) ENSMUST00000218069.1 uc288evw.1 uc288evw.2 uc288evw.1 uc288evw.2 
ENSMUST00000218071.2 Gm10773 ENSMUST00000218071.2 Gm10773 (from geneSymbol) AK149870 ENSMUST00000218071.1 uc287tpj.1 uc287tpj.2 uc287tpj.1 uc287tpj.2 
ENSMUST00000218077.3 4930486F22Rik ENSMUST00000218077.3 4930486F22Rik (from geneSymbol) AK019657 ENSMUST00000218077.1 ENSMUST00000218077.2 uc007gnq.1 uc007gnq.2 uc007gnq.3 uc007gnq.4 uc007gnq.5 uc007gnq.6 uc007gnq.1 uc007gnq.2 uc007gnq.3 uc007gnq.4 uc007gnq.5 uc007gnq.6 
ENSMUST00000218080.3 Gm36908 ENSMUST00000218080.3 predicted gene, 36908 (from RefSeq NR_156009.1) ENSMUST00000218080.1 ENSMUST00000218080.2 NR_156009 uc287qdw.1 uc287qdw.2 uc287qdw.3 uc287qdw.1 uc287qdw.2 uc287qdw.3 
ENSMUST00000218097.2 Gm47431 ENSMUST00000218097.2 Gm47431 (from geneSymbol) AK147018 ENSMUST00000218097.1 uc288ghr.1 uc288ghr.2 uc288ghr.1 uc288ghr.2 
ENSMUST00000218099.2 Gm47718 ENSMUST00000218099.2 Gm47718 (from geneSymbol) ENSMUST00000218099.1 uc287uio.1 uc287uio.2 uc287uio.1 uc287uio.2 
ENSMUST00000218100.2 Gm19337 ENSMUST00000218100.2 Gm19337 (from geneSymbol) ENSMUST00000218100.1 LF198040 uc287rtc.1 uc287rtc.2 uc287rtc.1 uc287rtc.2 
ENSMUST00000218103.4 2310002D06Rik ENSMUST00000218103.4 2310002D06Rik (from geneSymbol) AK009088 ENSMUST00000218103.1 ENSMUST00000218103.2 ENSMUST00000218103.3 uc029rty.1 uc029rty.2 uc029rty.3 uc029rty.4 uc029rty.1 uc029rty.2 uc029rty.3 uc029rty.4 
ENSMUST00000218107.2 Rps12 ENSMUST00000218107.2 ribosomal protein S12, transcript variant 1 (from RefSeq NM_011295.7) ENSMUST00000218107.1 NM_011295 P09388 P12728 P63323 Q6ZWZ6 RS12_MOUSE uc007epx.1 uc007epx.2 uc007epx.3 uc007epx.4 Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome (By similarity). Subunit of the 40S ribosomal complex (By similarity). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Subunit of the 40S ribosomal complex (By similarity). Nucleus, nucleolus Belongs to the eukaryotic ribosomal protein eS12 family. structural constituent of ribosome cytoplasm Golgi apparatus cytosol ribosome translation cytosolic large ribosomal subunit cytosolic small ribosomal subunit intracellular membrane-bounded organelle uc007epx.1 uc007epx.2 uc007epx.3 uc007epx.4 
ENSMUST00000218113.2 Gm40773 ENSMUST00000218113.2 Gm40773 (from geneSymbol) ENSMUST00000218113.1 uc287vcl.1 uc287vcl.2 uc287vcl.1 uc287vcl.2 
ENSMUST00000218114.2 C630031E19Rik ENSMUST00000218114.2 RIKEN cDNA C630031E19 gene (from RefSeq NR_046080.1) ENSMUST00000218114.1 NR_046080 uc029rrr.1 uc029rrr.2 uc029rrr.3 uc029rrr.1 uc029rrr.2 uc029rrr.3 
ENSMUST00000218132.3 Gm48882 ENSMUST00000218132.3 Gm48882 (from geneSymbol) AK087886 ENSMUST00000218132.1 ENSMUST00000218132.2 uc007gwe.1 uc007gwe.2 uc007gwe.3 uc007gwe.1 uc007gwe.2 uc007gwe.3 
ENSMUST00000218133.2 Krtap10-32 ENSMUST00000218133.2 Krtap10-32 (from geneSymbol) A0A1W2P860 A0A1W2P860_MOUSE ENSMUST00000218133.1 Gm18596 uc287smi.1 uc287smi.2 intermediate filament keratin filament uc287smi.1 uc287smi.2 
ENSMUST00000218134.2 Or6x1 ENSMUST00000218134.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFN6) ENSMUST00000218134.1 Olfr986 Or6x1 Q8VFN6 Q8VFN6_MOUSE uc292gdg.1 uc292gdg.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gdg.1 uc292gdg.2 
ENSMUST00000218151.2 Gm10741 ENSMUST00000218151.2 Gm10741 (from geneSymbol) ENSMUST00000218151.1 uc287vfw.1 uc287vfw.2 uc287vfw.1 uc287vfw.2 
ENSMUST00000218155.2 Gm48231 ENSMUST00000218155.2 Gm48231 (from geneSymbol) AK081989 ENSMUST00000218155.1 uc288hjq.1 uc288hjq.2 uc288hjq.1 uc288hjq.2 
ENSMUST00000218156.2 Gm47956 ENSMUST00000218156.2 Gm47956 (from geneSymbol) ENSMUST00000218156.1 uc287unn.1 uc287unn.2 uc287unn.1 uc287unn.2 
ENSMUST00000218177.2 Gm3137 ENSMUST00000218177.2 predicted gene, 3137 (from RefSeq NR_152191.1) ENSMUST00000218177.1 NR_152191 uc287ske.1 uc287ske.2 uc287ske.1 uc287ske.2 
ENSMUST00000218180.2 Gm19972 ENSMUST00000218180.2 Gm19972 (from geneSymbol) AK155426 ENSMUST00000218180.1 uc287rme.1 uc287rme.2 uc287rme.1 uc287rme.2 
ENSMUST00000218181.2 Gm47224 ENSMUST00000218181.2 Gm47224 (from geneSymbol) ENSMUST00000218181.1 uc287uqa.1 uc287uqa.2 uc287uqa.1 uc287uqa.2 
ENSMUST00000218183.2 Bcl9l ENSMUST00000218183.2 B cell CLL/lymphoma 9-like, transcript variant 3 (from RefSeq NM_001421307.1) B9l BCL9L_MOUSE ENSMUST00000218183.1 NM_001421307 Q641L9 Q67FY2 Q6GQY0 Q6I7B5 uc009pdv.1 uc009pdv.2 uc009pdv.3 Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1. Found in a complex with CDC73; CTNNB1 and PYGO1 (By similarity). Interacts with CTNNB1. Q67FY2; P35222: CTNNB1; Xeno; NbExp=2; IntAct=EBI-5234367, EBI-491549; Q67FY2; Q9NZC7: WWOX; Xeno; NbExp=3; IntAct=EBI-5234367, EBI-4320739; Nucleus Note=localized also in punctate nuclear bodies as well in the cytoplasm. Colocalizes with CTNNB1. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q67FY2-1; Sequence=Displayed; Name=2; IsoId=Q67FY2-2; Sequence=VSP_030209; Expressed in kidney, liver, lung, testis, brain, spleen, heart and skeletal muscle. Highly expressed in numerous colorectal tumors compared to corresponding non-cancerous tissues. Expressed in embryo. Tne C-terminal domain is important for its transactivation activity. Belongs to the BCL9 family. transcription coactivator activity protein binding nucleus nucleoplasm nucleolus beta-catenin binding positive regulation of epithelial to mesenchymal transition regulation of cell morphogenesis negative regulation of transforming growth factor beta receptor signaling pathway somatic stem cell population maintenance skeletal muscle cell differentiation positive regulation of transcription from RNA polymerase II promoter canonical Wnt signaling pathway beta-catenin-TCF complex uc009pdv.1 uc009pdv.2 uc009pdv.3 
ENSMUST00000218184.2 Izumo4 ENSMUST00000218184.2 IZUMO family member 4 (from RefSeq NM_027829.3) D3Z690 ENSMUST00000218184.1 IZUM4_MOUSE NM_027829 Q6PEP3 uc007gej.1 uc007gej.2 uc007gej.3 Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=D3Z690-1; Sequence=Displayed; Name=2; IsoId=D3Z690-2; Sequence=VSP_042504, VSP_042505; Izumo is the name of a Japanese shrine to marriage. Belongs to the Izumo family. molecular_function extracellular region biological_process uc007gej.1 uc007gej.2 uc007gej.3 
ENSMUST00000218192.2 Gm48867 ENSMUST00000218192.2 Gm48867 (from geneSymbol) ENSMUST00000218192.1 uc287uhb.1 uc287uhb.2 uc287uhb.1 uc287uhb.2 
ENSMUST00000218197.2 Gm48104 ENSMUST00000218197.2 Gm48104 (from geneSymbol) AK156832 ENSMUST00000218197.1 uc287uxd.1 uc287uxd.2 uc287uxd.1 uc287uxd.2 
ENSMUST00000218201.2 Gm48689 ENSMUST00000218201.2 Gm48689 (from geneSymbol) ENSMUST00000218201.1 uc287ugt.1 uc287ugt.2 uc287ugt.1 uc287ugt.2 
ENSMUST00000218204.2 Sult3a1 ENSMUST00000218204.2 sulfotransferase family 3A, member 1 (from RefSeq NM_020565.2) ENSMUST00000218204.1 NM_020565 Q059N0 Q059N0_MOUSE Sult3a1 uc011xcn.1 uc011xcn.2 uc011xcn.3 Belongs to the sulfotransferase 1 family. sulfotransferase activity transferase activity uc011xcn.1 uc011xcn.2 uc011xcn.3 
ENSMUST00000218206.2 Gm47580 ENSMUST00000218206.2 Gm47580 (from geneSymbol) AK031292 ENSMUST00000218206.1 uc287rel.1 uc287rel.2 uc287rel.1 uc287rel.2 
ENSMUST00000218207.2 Gm47976 ENSMUST00000218207.2 Gm47976 (from geneSymbol) AK039043 ENSMUST00000218207.1 uc287sop.1 uc287sop.2 uc287sop.1 uc287sop.2 
ENSMUST00000218213.2 ENSMUSG00000121427 ENSMUST00000218213.2 ENSMUSG00000121427 (from geneSymbol) ENSMUST00000218213.1 uc291tqe.1 uc291tqe.2 uc291tqe.1 uc291tqe.2 
ENSMUST00000218233.2 Gm40552 ENSMUST00000218233.2 Gm40552 (from geneSymbol) ENSMUST00000218233.1 uc288ilf.1 uc288ilf.2 uc288ilf.1 uc288ilf.2 
ENSMUST00000218235.3 Gm47767 ENSMUST00000218235.3 Gm47767 (from geneSymbol) ENSMUST00000218235.1 ENSMUST00000218235.2 uc288hmh.1 uc288hmh.2 uc288hmh.3 uc288hmh.1 uc288hmh.2 uc288hmh.3 
ENSMUST00000218244.2 ENSMUSG00000121708 ENSMUST00000218244.2 ENSMUSG00000121708 (from geneSymbol) ENSMUST00000218244.1 LF198229 uc011xng.1 uc011xng.2 uc011xng.3 uc011xng.1 uc011xng.2 uc011xng.3 
ENSMUST00000218246.2 Or52e19b ENSMUST00000218246.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N1Y4) ENSMUST00000218246.1 L7N1Y4 L7N1Y4_MOUSE Olfr603 Or52e19b uc291tqf.1 uc291tqf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tqf.1 uc291tqf.2 
ENSMUST00000218248.2 Gm48182 ENSMUST00000218248.2 Gm48182 (from geneSymbol) AK134565 ENSMUST00000218248.1 uc288gdw.1 uc288gdw.2 uc288gdw.1 uc288gdw.2 
ENSMUST00000218252.2 Gm48536 ENSMUST00000218252.2 Gm48536 (from geneSymbol) ENSMUST00000218252.1 uc288gfe.1 uc288gfe.2 uc288gfe.1 uc288gfe.2 
ENSMUST00000218256.2 Gm47218 ENSMUST00000218256.2 Gm47218 (from geneSymbol) AK053390 ENSMUST00000218256.1 uc288hio.1 uc288hio.2 uc288hio.1 uc288hio.2 
ENSMUST00000218261.2 Gm47590 ENSMUST00000218261.2 Gm47590 (from geneSymbol) AK082355 ENSMUST00000218261.1 uc287uau.1 uc287uau.2 uc287uau.1 uc287uau.2 
ENSMUST00000218282.2 Alx1 ENSMUST00000218282.2 Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:12929931). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:8673125). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity). (from UniProt Q8C8B0) AK047846 ALX1_MOUSE Alx1 Cart1 ENSMUST00000218282.1 Q8C370 Q8C8B0 uc287upk.1 uc287upk.2 Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:12929931). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:8673125). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity). Binds DNA as a homodimer; required for transcriptional activation (By similarity). Interacts (via homeobox domain) with EP300; acetylates ALX1 and stimulates its transcriptional activity (PubMed:12929931). Nucleus At 8.5 dpc and 9.5 dpc expression is restricted to forebrain mesenchymal cells. The OAR motif may negatively regulate DNA-binding and therefore transcriptional activity. It is found in the C-terminal transactivation domain that stimulates transcription. Acetylated at Lys-131 by EP300; increases interaction with EP300 and stimulates ALX1 transcriptional activity. Mice lacking Alx1 die within 24 hours of birth. The overt phenotype is acrania and degeneration of unprotected brain tissues. This is most probably the cause of the death since no other abnormality in limbs and visceral tissues is observed. The defect in cranial bone formation may be a consequence of extensive loss of forebrain head mesenchyme due to cell death and neural tube closure defects earlier during development. The penetrance of the acrania/meroanencephaly phenotype is variable between mice strains. Heterozygous mice appear normal and fertile. Belongs to the paired homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding neural crest cell migration neural tube closure DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm transcription factor complex Golgi apparatus regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification positive regulation of epithelial to mesenchymal transition mesenchymal cell development nuclear body embryonic limb morphogenesis protein homodimerization activity sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity embryonic skeletal system morphogenesis palate development uc287upk.1 uc287upk.2 
ENSMUST00000218285.2 Gm48877 ENSMUST00000218285.2 Gm48877 (from geneSymbol) ENSMUST00000218285.1 uc287via.1 uc287via.2 uc287via.1 uc287via.2 
ENSMUST00000218311.2 Rnf212b ENSMUST00000218311.2 ring finger protein 212B (from RefSeq NM_001370899.1) D3Z2T6 D3Z423 ENSMUST00000218311.1 Gm10332 NM_001370899 R212B_MOUSE uc288uhx.1 uc288uhx.2 synaptonemal complex synapsis protein sumoylation SUMO transferase activity metal ion binding uc288uhx.1 uc288uhx.2 
ENSMUST00000218315.2 Pan2 ENSMUST00000218315.2 PAN2 poly(A) specific ribonuclease subunit, transcript variant 2 (from RefSeq NM_001252326.1) ENSMUST00000218315.1 Kiaa0710 NM_001252326 PAN2_MOUSE Pan2 Q3TZK5 Q68FH6 Q6ZQ63 Q8BGF7 Usp52 uc007hmf.1 uc007hmf.2 uc007hmf.3 uc007hmf.4 Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1 (PubMed:16284618). Also acts as an important regulator of the HIF1A- mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation (By similarity). Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence=; Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 metal cations per subunit in the catalytic exonuclease domain. ; Positively regulated by the regulatory subunit PAN3. Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex (By similarity). Interacts with PAN3 isoform 1/Pan3L and isoform 3/Pan3S (By similarity). Interacts with ZFP36 (PubMed:21078877). Cytoplasm, P-body cleus Note=Shuttles between nucleus and cytoplasm. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8BGF7-1; Sequence=Displayed; Name=2; IsoId=Q8BGF7-2; Sequence=VSP_023752; Name=3; IsoId=Q8BGF7-3; Sequence=VSP_023750, VSP_023752; Name=4; IsoId=Q8BGF7-4; Sequence=VSP_023751; Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex. The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3. Belongs to the peptidase C19 family. PAN2 subfamily. Sequence=BAC98006.2; Type=Erroneous initiation; Evidence=; 3'-5'-exoribonuclease activity nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA poly(A) tail shortening nuclear-transcribed mRNA catabolic process, exonucleolytic P-body nucleic acid binding nuclease activity exonuclease activity poly(A)-specific ribonuclease activity protein binding nucleus cytoplasm mRNA processing positive regulation of cytoplasmic mRNA processing body assembly hydrolase activity PAN complex metal ion binding nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic uc007hmf.1 uc007hmf.2 uc007hmf.3 uc007hmf.4 
ENSMUST00000218320.2 Gm47023 ENSMUST00000218320.2 Gm47023 (from geneSymbol) ENSMUST00000218320.1 uc287rbb.1 uc287rbb.2 uc287rbb.1 uc287rbb.2 
ENSMUST00000218323.2 Gm36660 ENSMUST00000218323.2 Gm36660 (from geneSymbol) AK028654 ENSMUST00000218323.1 uc288hls.1 uc288hls.2 uc288hls.1 uc288hls.2 
ENSMUST00000218324.3 Gm48578 ENSMUST00000218324.3 Gm48578 (from geneSymbol) ENSMUST00000218324.1 ENSMUST00000218324.2 uc288gfo.1 uc288gfo.2 uc288gfo.3 uc288gfo.1 uc288gfo.2 uc288gfo.3 
ENSMUST00000218325.2 Or51q1c ENSMUST00000218325.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRQ2) A1L1B3 ENSMUST00000218325.1 Olfr638 Or51q1c Q7TRQ2 Q7TRQ2_MOUSE uc291tsn.1 uc291tsn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tsn.1 uc291tsn.2 
ENSMUST00000218326.2 A230081H15Rik ENSMUST00000218326.2 A230081H15Rik (from geneSymbol) AK038984 ENSMUST00000218326.1 uc287qjy.1 uc287qjy.2 uc287qjy.1 uc287qjy.2 
ENSMUST00000218329.2 Cdc5lrt8 ENSMUST00000218329.2 Belongs to the CEF1 family. (from UniProt A0A1W2P855) A0A1W2P855 A0A1W2P855_MOUSE Cdc5lrt8 ENSMUST00000218329.1 Gm9046 LF224722 uc029rir.1 uc029rir.2 uc029rir.3 Belongs to the CEF1 family. DNA binding uc029rir.1 uc029rir.2 uc029rir.3 
ENSMUST00000218333.3 Gm47078 ENSMUST00000218333.3 Gm47078 (from geneSymbol) AK030229 ENSMUST00000218333.1 ENSMUST00000218333.2 uc287rwv.1 uc287rwv.2 uc287rwv.3 uc287rwv.1 uc287rwv.2 uc287rwv.3 
ENSMUST00000218342.2 Slc10a1 ENSMUST00000218342.2 solute carrier family 10 (sodium/bile acid cotransporter family), member 1, transcript variant 2 (from RefSeq NM_011387.2) A0A8V5KH54 A0A8V5KH54_MOUSE ENSMUST00000218342.1 NM_011387 Slc10a1 uc007obs.1 uc007obs.2 uc007obs.3 uc007obs.4 Membrane ; Multi- pass membrane protein Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. uc007obs.1 uc007obs.2 uc007obs.3 uc007obs.4 
ENSMUST00000218344.2 BC042761 ENSMUST00000218344.2 cDNA sequence BC042761 (from RefSeq NR_131112.1) ENSMUST00000218344.1 NR_131112 uc056yqq.1 uc056yqq.2 uc056yqq.3 uc056yqq.1 uc056yqq.2 uc056yqq.3 
ENSMUST00000218348.3 Gm10752 ENSMUST00000218348.3 Gm10752 (from geneSymbol) AK145269 ENSMUST00000218348.1 ENSMUST00000218348.2 uc287uxs.1 uc287uxs.2 uc287uxs.3 uc287uxs.1 uc287uxs.2 uc287uxs.3 
ENSMUST00000218349.2 B230217J21Rik ENSMUST00000218349.2 B230217J21Rik (from geneSymbol) AK080583 ENSMUST00000218349.1 uc288gfd.1 uc288gfd.2 uc288gfd.1 uc288gfd.2 
ENSMUST00000218351.2 Gm47644 ENSMUST00000218351.2 Gm47644 (from geneSymbol) ENSMUST00000218351.1 uc287rfm.1 uc287rfm.2 uc287rfm.1 uc287rfm.2 
ENSMUST00000218354.2 Gm47831 ENSMUST00000218354.2 Gm47831 (from geneSymbol) AK089524 ENSMUST00000218354.1 uc287qkj.1 uc287qkj.2 uc287qkj.1 uc287qkj.2 
ENSMUST00000218355.2 Gm48146 ENSMUST00000218355.2 Gm48146 (from geneSymbol) ENSMUST00000218355.1 LF308253 uc287rrk.1 uc287rrk.2 uc287rrk.1 uc287rrk.2 
ENSMUST00000218358.2 Gm48072 ENSMUST00000218358.2 Gm48072 (from geneSymbol) ENSMUST00000218358.1 uc287rsw.1 uc287rsw.2 uc287rsw.1 uc287rsw.2 
ENSMUST00000218362.2 Ttc9 ENSMUST00000218362.2 tetratricopeptide repeat domain 9 (from RefSeq NM_001033149.3) B2RTC7 ENSMUST00000218362.1 Kiaa0227 NM_001033149 Q3TTA0 Q3V038 Q6A0A0 Q8K336 TTC9A_MOUSE Ttc9a uc007ocn.1 uc007ocn.2 uc007ocn.3 uc007ocn.4 This gene encodes a protein that contains three tetratricopeptide repeats. The human gene has been shown to be hormonally regulated in breast cancer cells and may play a role in cancer cell invasion and metastasis. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK172918.1, SRR1660817.197822.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Belongs to the TTC9 family. Sequence=AAH28891.1; Type=Erroneous initiation; Evidence=; Sequence=BAD32196.1; Type=Erroneous initiation; Evidence=; bone development uc007ocn.1 uc007ocn.2 uc007ocn.3 uc007ocn.4 
ENSMUST00000218378.2 Gm48835 ENSMUST00000218378.2 Gm48835 (from geneSymbol) AK090201 ENSMUST00000218378.1 uc288gmu.1 uc288gmu.2 uc288gmu.1 uc288gmu.2 
ENSMUST00000218381.2 C730027H18Rik ENSMUST00000218381.2 RIKEN cDNA C730027H18 gene (from RefSeq NR_038040.1) ENSMUST00000218381.1 NR_038040 uc007foj.1 uc007foj.2 uc007foj.3 uc007foj.1 uc007foj.2 uc007foj.3 
ENSMUST00000218385.2 Or7g19 ENSMUST00000218385.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRG9) ENSMUST00000218385.1 Olfr832 Olfr834 Or7g19 Q7TRG9 Q7TRG9_MOUSE uc292eta.1 uc292eta.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292eta.1 uc292eta.2 
ENSMUST00000218388.3 Gm48428 ENSMUST00000218388.3 Gm48428 (from geneSymbol) ENSMUST00000218388.1 ENSMUST00000218388.2 uc287ujh.1 uc287ujh.2 uc287ujh.3 uc287ujh.1 uc287ujh.2 uc287ujh.3 
ENSMUST00000218404.3 Gm47566 ENSMUST00000218404.3 Gm47566 (from geneSymbol) ENSMUST00000218404.1 ENSMUST00000218404.2 uc288ilx.1 uc288ilx.2 uc288ilx.3 uc288ilx.1 uc288ilx.2 uc288ilx.3 
ENSMUST00000218411.2 Scarna3b ENSMUST00000218411.2 small Cajal body-specific RNA 3B (from RefSeq NR_028544.1) ENSMUST00000218411.1 NR_028544 uc288hml.1 uc288hml.2 uc288hml.1 uc288hml.2 
ENSMUST00000218415.2 Gm47822 ENSMUST00000218415.2 Gm47822 (from geneSymbol) ENSMUST00000218415.1 uc288exx.1 uc288exx.2 uc288exx.1 uc288exx.2 
ENSMUST00000218426.2 Tex21 ENSMUST00000218426.2 testis expressed gene 21, transcript variant 2 (from RefSeq NM_001159532.1) ENSMUST00000218426.1 NM_001159532 Q497Q3 Q497Q3_MOUSE Tex21 uc007nxy.1 uc007nxy.2 uc007nxy.3 uc007nxy.4 molecular_function cellular_component biological_process uc007nxy.1 uc007nxy.2 uc007nxy.3 uc007nxy.4 
ENSMUST00000218430.2 Gm48021 ENSMUST00000218430.2 Gm48021 (from geneSymbol) ENSMUST00000218430.1 uc287sah.1 uc287sah.2 uc287sah.1 uc287sah.2 
ENSMUST00000218443.2 Krtap10-24 ENSMUST00000218443.2 predicted gene 3285 (from RefSeq NM_001101631.1) A0A1W2P7U0 A0A1W2P7U0_MOUSE ENSMUST00000218443.1 Gm3285 NM_001101631 uc011xhn.1 uc011xhn.2 uc011xhn.3 molecular_function cellular_component intermediate filament biological_process keratin filament uc011xhn.1 uc011xhn.2 uc011xhn.3 
ENSMUST00000218446.2 Gm48521 ENSMUST00000218446.2 Gm48521 (from geneSymbol) AK035940 ENSMUST00000218446.1 uc287ujq.1 uc287ujq.2 uc287ujq.1 uc287ujq.2 
ENSMUST00000218448.2 Gm48123 ENSMUST00000218448.2 Gm48123 (from geneSymbol) ENSMUST00000218448.1 LF197990 uc287rbe.1 uc287rbe.2 uc287rbe.1 uc287rbe.2 
ENSMUST00000218457.2 Gm8633 ENSMUST00000218457.2 predicted gene 8633 (from RefSeq NR_045179.1) ENSMUST00000218457.1 NR_045179 uc029rev.1 uc029rev.2 uc029rev.3 uc029rev.1 uc029rev.2 uc029rev.3 
ENSMUST00000218458.2 ENSMUSG00000121695 ENSMUST00000218458.2 ENSMUSG00000121695 (from geneSymbol) ENSMUST00000218458.1 uc287upd.1 uc287upd.2 uc287upd.1 uc287upd.2 
ENSMUST00000218459.2 ENSMUSG00000121417 ENSMUST00000218459.2 ENSMUSG00000121417 (from geneSymbol) ENSMUST00000218459.1 uc287yjq.1 uc287yjq.2 uc287yjq.1 uc287yjq.2 
ENSMUST00000218463.2 4930532I03Rik ENSMUST00000218463.2 RIKEN cDNA 4930532I03 gene, transcript variant 1 (from RefSeq NR_131026.1) ENSMUST00000218463.1 NR_131026 uc007gyt.1 uc007gyt.2 uc007gyt.1 uc007gyt.2 
ENSMUST00000218472.2 Gm35608 ENSMUST00000218472.2 Gm35608 (from geneSymbol) BC099974 ENSMUST00000218472.1 uc287sjt.1 uc287sjt.2 uc287sjt.1 uc287sjt.2 
ENSMUST00000218476.2 Gm47737 ENSMUST00000218476.2 Gm47737 (from geneSymbol) AK076913 ENSMUST00000218476.1 uc287rfy.1 uc287rfy.2 uc287rfy.1 uc287rfy.2 
ENSMUST00000218483.2 Or52e2 ENSMUST00000218483.2 Membrane ; Multi- pass membrane protein (from UniProt Q8VGV8) ENSMUST00000218483.1 Olfr589 Or52e2 Q8VGV8 Q8VGV8_MOUSE uc291tpj.1 uc291tpj.2 Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tpj.1 uc291tpj.2 
ENSMUST00000218493.2 Gm48757 ENSMUST00000218493.2 Gm48757 (from geneSymbol) ENSMUST00000218493.1 uc287plk.1 uc287plk.2 uc287plk.1 uc287plk.2 
ENSMUST00000218501.3 Gm30228 ENSMUST00000218501.3 Gm30228 (from geneSymbol) ENSMUST00000218501.1 ENSMUST00000218501.2 uc287qfo.1 uc287qfo.2 uc287qfo.3 uc287qfo.1 uc287qfo.2 uc287qfo.3 
ENSMUST00000218509.2 Gm47623 ENSMUST00000218509.2 Gm47623 (from geneSymbol) ENSMUST00000218509.1 uc287rez.1 uc287rez.2 uc287rez.1 uc287rez.2 
ENSMUST00000218512.3 Gm32105 ENSMUST00000218512.3 Gm32105 (from geneSymbol) ENSMUST00000218512.1 ENSMUST00000218512.2 uc287pqn.1 uc287pqn.2 uc287pqn.3 uc287pqn.1 uc287pqn.2 uc287pqn.3 
ENSMUST00000218514.2 Gm34544 ENSMUST00000218514.2 Gm34544 (from geneSymbol) ENSMUST00000218514.1 uc287sbm.1 uc287sbm.2 uc287sbm.1 uc287sbm.2 
ENSMUST00000218525.2 Or13s1-ps1 ENSMUST00000218525.2 Or13s1-ps1 (from geneSymbol) ENSMUST00000218525.1 uc291wvv.1 uc291wvv.2 uc291wvv.1 uc291wvv.2 
ENSMUST00000218527.2 Gm48854 ENSMUST00000218527.2 Gm48854 (from geneSymbol) ENSMUST00000218527.1 uc287prd.1 uc287prd.2 uc287prd.1 uc287prd.2 
ENSMUST00000218529.2 Gm34376 ENSMUST00000218529.2 Gm34376 (from geneSymbol) ENSMUST00000218529.1 uc287sbe.1 uc287sbe.2 uc287sbe.1 uc287sbe.2 
ENSMUST00000218530.2 Gm48045 ENSMUST00000218530.2 Gm48045 (from geneSymbol) ENSMUST00000218530.1 uc287qlu.1 uc287qlu.2 uc287qlu.1 uc287qlu.2 
ENSMUST00000218535.2 Or51i1 ENSMUST00000218535.2 olfactory receptor family 51 subfamily I member 1D (from RefSeq NM_146822.2) E9Q7P5 E9Q7P5_MOUSE ENSMUST00000218535.1 NM_146822 Olfr640 Or51i1 uc291tsq.1 uc291tsq.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC106802.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tsq.1 uc291tsq.2 
ENSMUST00000218544.2 4921516A02Rik ENSMUST00000218544.2 4921516A02Rik (from geneSymbol) AK132664 ENSMUST00000218544.1 uc287spo.1 uc287spo.2 uc287spo.1 uc287spo.2 
ENSMUST00000218546.2 Or11h7 ENSMUST00000218546.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q840) E9Q840 E9Q840_MOUSE ENSMUST00000218546.1 Olfr746 Or11h7 uc288tma.1 uc288tma.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc288tma.1 uc288tma.2 
ENSMUST00000218555.4 Gm30025 ENSMUST00000218555.4 Gm30025 (from geneSymbol) ENSMUST00000218555.1 ENSMUST00000218555.2 ENSMUST00000218555.3 uc288hmn.1 uc288hmn.2 uc288hmn.3 uc288hmn.4 uc288hmn.1 uc288hmn.2 uc288hmn.3 uc288hmn.4 
ENSMUST00000218558.2 Gm47032 ENSMUST00000218558.2 Gm47032 (from geneSymbol) ENSMUST00000218558.1 uc287uol.1 uc287uol.2 uc287uol.1 uc287uol.2 
ENSMUST00000218567.2 Gm48075 ENSMUST00000218567.2 Gm48075 (from geneSymbol) ENSMUST00000218567.1 uc288euf.1 uc288euf.2 uc288euf.1 uc288euf.2 
ENSMUST00000218569.2 Gm34297 ENSMUST00000218569.2 Gm34297 (from geneSymbol) AK132976 ENSMUST00000218569.1 uc287ukg.1 uc287ukg.2 uc287ukg.1 uc287ukg.2 
ENSMUST00000218583.2 Myt1l ENSMUST00000218583.2 myelin transcription factor 1-like, transcript variant 2 (from RefSeq NM_008666.3) A2RRK5 D3Z1P7 ENSMUST00000218583.1 Kiaa1106 MYT1L_MOUSE Myt1l NM_008666 Nzf1 O08996 P97500 Png1 Q33DP0 Q8C643 Q8C7L4 Q8CHB4 uc007nge.1 uc007nge.2 uc007nge.3 Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation (PubMed:28379941). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (PubMed:28379941). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (PubMed:28379941). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (PubMed:28379941). The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (PubMed:28379941). Interacts with SIN3B. Nucleus romosome Note=Preferentially binds to DNA binding sites that are in an open chromatin configuration (PubMed:28379941). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P97500-1; Sequence=Displayed; Name=2; IsoId=P97500-2; Sequence=VSP_015728; Name=3; IsoId=P97500-3; Sequence=VSP_015726, VSP_015729, VSP_015730, VSP_015731; Name=4; IsoId=P97500-4; Sequence=VSP_015727, VSP_015728, VSP_015730, VSP_015731; Brain. Expression is restricted to and present throughout the embryonic CNS and developing peripheral neural structures. In the embryonic CNS, expression is restricted to postmitotic neuronal regions. During the neurogenetic period (11 dpc-17 dpc) expression is associated temporally and spatially with the known generation of the first cortical neurons with known gradients of neuron production. Expression continues in developing postmitotic cortical neurons throughout embryonic development and is expressed within 2 days of neuronal induction in P19 cells. Up-regulated by retinoic acid. Belongs to the MYT1 family. Sequence=AAC53457.1; Type=Frameshift; Evidence=; Sequence=BAC41467.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding nucleus chromosome regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development nervous system development zinc ion binding cell differentiation neuron differentiation retinoic acid-responsive element binding positive regulation of transcription from RNA polymerase II promoter metal ion binding neuron fate commitment neuron fate specification neuron development cobalt ion binding uc007nge.1 uc007nge.2 uc007nge.3 
ENSMUST00000218588.2 Gm48744 ENSMUST00000218588.2 Gm48744 (from geneSymbol) ENSMUST00000218588.1 uc287pld.1 uc287pld.2 uc287pld.1 uc287pld.2 
ENSMUST00000218594.3 Gm47257 ENSMUST00000218594.3 Gm47257 (from geneSymbol) ENSMUST00000218594.1 ENSMUST00000218594.2 LF198032 uc287rqp.1 uc287rqp.2 uc287rqp.3 uc287rqp.1 uc287rqp.2 uc287rqp.3 
ENSMUST00000218599.2 Gm47027 ENSMUST00000218599.2 Gm47027 (from geneSymbol) AK136139 ENSMUST00000218599.1 uc287vdy.1 uc287vdy.2 uc287vdy.1 uc287vdy.2 
ENSMUST00000218612.2 Gm40765 ENSMUST00000218612.2 Gm40765 (from geneSymbol) ENSMUST00000218612.1 uc287uwz.1 uc287uwz.2 uc287uwz.1 uc287uwz.2 
ENSMUST00000218616.2 Gm47922 ENSMUST00000218616.2 Gm47922 (from geneSymbol) ENSMUST00000218616.1 uc287soe.1 uc287soe.2 uc287soe.1 uc287soe.2 
ENSMUST00000218625.2 ENSMUSG00000121436 ENSMUST00000218625.2 ENSMUSG00000121436 (from geneSymbol) ENSMUST00000218625.1 uc287ocg.1 uc287ocg.2 uc287ocg.1 uc287ocg.2 
ENSMUST00000218629.2 Gm47033 ENSMUST00000218629.2 Gm47033 (from geneSymbol) AK049037 ENSMUST00000218629.1 uc287uot.1 uc287uot.2 uc287uot.1 uc287uot.2 
ENSMUST00000218635.2 Utrn ENSMUST00000218635.2 Cytoplasm, cytoskeleton (from UniProt E9Q6R7) E9Q6R7 E9Q6R7_MOUSE ENSMUST00000218635.1 Utrn Y12229 uc007eke.1 uc007eke.2 uc007eke.3 Cytoplasm, cytoskeleton positive regulation of cell-matrix adhesion actin binding integrin binding protein binding nucleoplasm cytoplasm cytoskeleton plasma membrane adult somatic muscle development neuromuscular junction development zinc ion binding response to denervation involved in regulation of muscle adaptation dystrophin-associated glycoprotein complex membrane vinculin binding protein kinase binding cell junction filopodium growth cone cortical actin cytoskeleton filopodium membrane neuromuscular junction macromolecular complex sarcolemma synapse postsynaptic membrane metal ion binding actin filament binding contractile ring uc007eke.1 uc007eke.2 uc007eke.3 
ENSMUST00000218639.2 Gm48543 ENSMUST00000218639.2 Gm48543 (from geneSymbol) ENSMUST00000218639.1 uc288gfj.1 uc288gfj.2 uc288gfj.1 uc288gfj.2 
ENSMUST00000218641.2 Gm30346 ENSMUST00000218641.2 Gm30346 (from geneSymbol) ENSMUST00000218641.1 LF198096 uc287sqh.1 uc287sqh.2 uc287sqh.1 uc287sqh.2 
ENSMUST00000218661.2 Gm47608 ENSMUST00000218661.2 Gm47608 (from geneSymbol) ENSMUST00000218661.1 uc287rep.1 uc287rep.2 uc287rep.1 uc287rep.2 
ENSMUST00000218662.2 Gm30122 ENSMUST00000218662.2 Gm30122 (from geneSymbol) ENSMUST00000218662.1 uc287soo.1 uc287soo.2 uc287soo.1 uc287soo.2 
ENSMUST00000218663.2 Or7c19 ENSMUST00000218663.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGB8) ENSMUST00000218663.1 Olfr371 Or7c19 Q8VGB8 Q8VGB8_MOUSE uc292bsn.1 uc292bsn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292bsn.1 uc292bsn.2 
ENSMUST00000218664.2 Gm48804 ENSMUST00000218664.2 Gm48804 (from geneSymbol) ENSMUST00000218664.1 uc287vho.1 uc287vho.2 uc287vho.1 uc287vho.2 
ENSMUST00000218667.3 5330439M10Rik ENSMUST00000218667.3 5330439M10Rik (from geneSymbol) AK019940 ENSMUST00000218667.1 ENSMUST00000218667.2 uc287vcn.1 uc287vcn.2 uc287vcn.3 uc287vcn.1 uc287vcn.2 uc287vcn.3 
ENSMUST00000218673.2 Gm47591 ENSMUST00000218673.2 Gm47591 (from geneSymbol) AK138336 ENSMUST00000218673.1 uc287uaj.1 uc287uaj.2 uc287uaj.1 uc287uaj.2 
ENSMUST00000218674.2 A130012E19Rik ENSMUST00000218674.2 A130012E19Rik (from geneSymbol) ENSMUST00000218674.1 uc287uyd.1 uc287uyd.2 uc287uyd.1 uc287uyd.2 
ENSMUST00000218699.2 Plekhn1 ENSMUST00000218699.2 Controls the stability of the leptin mRNA harboring an AU- rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (PubMed:27616329). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4- phosphate (PtdIns(4)P) and phosphatidylserine (PS) (By similarity). (from UniProt Q8C886) A0A1W2P6Q7 A0A1W2P7X5 BC031374 Clpabp ENSMUST00000218699.1 PKHN1_MOUSE Q8C886 Q8R3H1 uc008wgp.1 uc008wgp.2 uc008wgp.3 uc008wgp.4 Controls the stability of the leptin mRNA harboring an AU- rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (PubMed:27616329). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4- phosphate (PtdIns(4)P) and phosphatidylserine (PS) (By similarity). Found in a complex with cytochrome c mRNA and various ribosomal proteins. Interacts with C1QBP, ELAVL1 and BID. Q8C886; P39428: Traf1; NbExp=6; IntAct=EBI-646708, EBI-520123; Cell membrane ; Lipid-anchor Mitochondrion membrane Mitochondrion Note=Interaction with C1QBP and phosphorylation is essential for its mitochondrial localization. Localizes on the microtubule in the form of small granules. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C886-1; Sequence=Displayed; Name=2; IsoId=Q8C886-2; Sequence=VSP_059841, VSP_059842, VSP_059843; Name=3; IsoId=Q8C886-3; Sequence=VSP_059844, VSP_059845; Testis and adipose tissue (at protein level). Ubiquitous. Both PH domains are essential for its mitochondrial localization. Phosphorylation is essential for its mitochondrial localization and regulates its interaction with C1QBP. Male knockout mice (KO) gradually become fat after 20 weeks of age compared to the wild-type (WT) mice. At 36 weeks, weight differences in whole body, epididymal fat pad, and liver between the KO and WT mice is significant. KO mice exhibit a hyperphagia phenotype with the plasma concentration of leptin higher in the KO mice than in the WT mice. response to hypoxia phosphatidylserine binding protein binding mitochondrion cytoskeleton plasma membrane membrane mitochondrial membrane positive regulation of apoptotic process 3'-UTR-mediated mRNA destabilization phosphatidic acid binding cardiolipin binding phosphatidylinositol phosphate binding uc008wgp.1 uc008wgp.2 uc008wgp.3 uc008wgp.4 
ENSMUST00000218700.3 Gm47715 ENSMUST00000218700.3 Gm47715 (from geneSymbol) ENSMUST00000218700.1 ENSMUST00000218700.2 uc287qcs.1 uc287qcs.2 uc287qcs.3 uc287qcs.1 uc287qcs.2 uc287qcs.3 
ENSMUST00000218706.2 Gm48205 ENSMUST00000218706.2 Gm48205 (from geneSymbol) AK047333 ENSMUST00000218706.1 uc287urb.1 uc287urb.2 uc287urb.1 uc287urb.2 
ENSMUST00000218722.2 Apon ENSMUST00000218722.2 apolipoprotein N (from RefSeq NM_133996.3) Apon ENSMUST00000218722.1 G3X9D6 G3X9D6_MOUSE NM_133996 uc029rjt.1 uc029rjt.2 uc029rjt.3 uc029rjt.4 molecular_function extracellular space cytoplasm biological_process uc029rjt.1 uc029rjt.2 uc029rjt.3 uc029rjt.4 
ENSMUST00000218746.2 Gm48435 ENSMUST00000218746.2 Gm48435 (from geneSymbol) AK020554 ENSMUST00000218746.1 uc287vgg.1 uc287vgg.2 uc287vgg.1 uc287vgg.2 
ENSMUST00000218749.2 Krtap10-35 ENSMUST00000218749.2 predicted gene, 36176 (from RefSeq NM_001370835.1) A0A1W2P8D5 A0A1W2P8D5_MOUSE ENSMUST00000218749.1 Gm36176 NM_001370835 uc287smt.1 uc287smt.2 intermediate filament keratin filament uc287smt.1 uc287smt.2 
ENSMUST00000218757.3 4930533K18Rik ENSMUST00000218757.3 4930533K18Rik (from geneSymbol) AK015956 ENSMUST00000218757.1 ENSMUST00000218757.2 uc287sao.1 uc287sao.2 uc287sao.3 uc287sao.1 uc287sao.2 uc287sao.3 
ENSMUST00000218762.3 4930477N07Rik ENSMUST00000218762.3 4930477N07Rik (from geneSymbol) AK015581 ENSMUST00000218762.1 ENSMUST00000218762.2 uc056yim.1 uc056yim.2 uc056yim.3 uc056yim.1 uc056yim.2 uc056yim.3 
ENSMUST00000218766.2 Specc1l ENSMUST00000218766.2 sperm antigen with calponin homology and coiled-coil domains 1-like, transcript variant 2 (from RefSeq NM_153406.3) CYTSA_MOUSE Cytsa ENSMUST00000218766.1 Kiaa0376 NM_153406 Q2KN98 Q8CHF9 uc007fqe.1 uc007fqe.2 uc007fqe.3 uc007fqe.4 Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity). May interact with both microtubules and actin cytoskeleton. Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, spindle Cell junction, gap junction Note=Colocalizes with beta-tubulin, acetylated alpha-tubulin and F- actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center (By similarity). At 9.5-10.5 dpc, expressed in the developing maxillary prominence and the lateral nasal process, as well as in the limbs and eye. Belongs to the cytospin-A family. Sequence=BAC41420.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cytoplasm microtubule organizing center spindle cytosol cytoskeleton gap junction negative regulation of microtubule depolymerization cell cycle cell adhesion actin cytoskeleton microtubule cytoskeleton cell migration actin cytoskeleton organization cell junction negative regulation of actin filament depolymerization filamentous actin cell division face morphogenesis uc007fqe.1 uc007fqe.2 uc007fqe.3 uc007fqe.4 
ENSMUST00000218768.2 Gm49167 ENSMUST00000218768.2 Gm49167 (from geneSymbol) ENSMUST00000218768.1 uc287ugq.1 uc287ugq.2 uc287ugq.1 uc287ugq.2 
ENSMUST00000218769.2 Gm30165 ENSMUST00000218769.2 Gm30165 (from geneSymbol) ENSMUST00000218769.1 uc287qfn.1 uc287qfn.2 uc287qfn.1 uc287qfn.2 
ENSMUST00000218771.2 Anapc15-ps ENSMUST00000218771.2 Belongs to the APC15 family. (from UniProt A0A1W2P6Q9) A0A1W2P6Q9 A0A1W2P6Q9_MOUSE Anapc15-ps ENSMUST00000218771.1 uc287uii.1 uc287uii.2 Belongs to the APC15 family. anaphase-promoting complex regulation of mitotic cell cycle spindle assembly checkpoint uc287uii.1 uc287uii.2 
ENSMUST00000218774.2 Gm20597 ENSMUST00000218774.2 predicted gene, 20597 (from RefSeq NR_037973.2) ENSMUST00000218774.1 NR_037973 uc029qxf.1 uc029qxf.2 uc029qxf.1 uc029qxf.2 
ENSMUST00000218778.2 Gm47226 ENSMUST00000218778.2 Gm47226 (from geneSymbol) ENSMUST00000218778.1 uc287uqd.1 uc287uqd.2 uc287uqd.1 uc287uqd.2 
ENSMUST00000218783.2 Gm47622 ENSMUST00000218783.2 Gm47622 (from geneSymbol) ENSMUST00000218783.1 uc287rfb.1 uc287rfb.2 uc287rfb.1 uc287rfb.2 
ENSMUST00000218784.2 Gm47221 ENSMUST00000218784.2 Gm47221 (from geneSymbol) ENSMUST00000218784.1 uc287upw.1 uc287upw.2 uc287upw.1 uc287upw.2 
ENSMUST00000218788.2 Samd11 ENSMUST00000218788.2 sterile alpha motif domain containing 11, transcript variant 2 (from RefSeq NM_001355709.1) ENSMUST00000218788.1 NM_001355709 Q1RNF8 Q3TU11 SAM11_MOUSE uc029vbl.1 uc029vbl.2 uc029vbl.3 May play a role in photoreceptor development. Homodimer. Nucleus Predominantly expressed in retinal photoreceptors and pineal gland. Expressed from 18 dpc in the outer aspect of neuroblastic layer (NBL). negative regulation of transcription from RNA polymerase II promoter nucleus SAM domain binding PH domain binding protein self-association uc029vbl.1 uc029vbl.2 uc029vbl.3 
ENSMUST00000218791.3 Gm29674 ENSMUST00000218791.3 Gm29674 (from geneSymbol) AK043688 ENSMUST00000218791.1 ENSMUST00000218791.2 uc287usj.1 uc287usj.2 uc287usj.3 uc287usj.1 uc287usj.2 uc287usj.3 
ENSMUST00000218795.2 Gm47738 ENSMUST00000218795.2 Gm47738 (from geneSymbol) ENSMUST00000218795.1 uc287rfw.1 uc287rfw.2 uc287rfw.1 uc287rfw.2 
ENSMUST00000218800.3 Gm46210 ENSMUST00000218800.3 Gm46210 (from geneSymbol) ENSMUST00000218800.1 ENSMUST00000218800.2 uc287pmb.1 uc287pmb.2 uc287pmb.3 uc287pmb.1 uc287pmb.2 uc287pmb.3 
ENSMUST00000218802.2 Gm49358 ENSMUST00000218802.2 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; (from UniProt A0A1W2P799) A0A1W2P799 A0A1W2P799_MOUSE AY651022 ENSMUST00000218802.1 Gm49358 uc287tvb.1 uc287tvb.2 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Belongs to the 5'(3')-deoxyribonucleotidase family. 5'-nucleotidase activity dephosphorylation metal ion binding uc287tvb.1 uc287tvb.2 
ENSMUST00000218808.2 Gm47621 ENSMUST00000218808.2 Gm47621 (from geneSymbol) AB343833 ENSMUST00000218808.1 uc287rfa.1 uc287rfa.2 uc287rfa.1 uc287rfa.2 
ENSMUST00000218811.2 Gm48791 ENSMUST00000218811.2 Gm48791 (from geneSymbol) ENSMUST00000218811.1 uc288evv.1 uc288evv.2 uc288evv.1 uc288evv.2 
ENSMUST00000218823.2 Grik2 ENSMUST00000218823.2 glutamate receptor, ionotropic, kainate 2 (beta 2), transcript variant 3 (from RefSeq NM_001358866.2) ENSMUST00000218823.1 GRIK2_MOUSE Glur6 NM_001358866 P39087 Q60933 uc007fah.1 uc007fah.2 uc007fah.3 uc007fah.4 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been found for this gene. [provided by RefSeq, Jul 2008]. Ionotropic glutamate receptor (PubMed:19217376, PubMed:31474366). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Modulates cell surface expression of NETO2 (PubMed:19217376). Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (PubMed:31474366). Cold receptor activity activated by temperatures between 10-19 degrees Celsius. Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). Assembles into a kainate-gated homomeric channel that does not bind AMPA. GRIK2 associated to GRIK5 forms functional channels that can be gated by AMPA. Interacts with DLG4 (By similarity). Interacts (via C-terminus) with KLHL17 (via kelch repeats); the interaction targets GRIK2 for degradation via ubiquitin- proteasome pathway (By similarity). Interacts with NETO2. Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Event=Alternative splicing; Named isoforms=2; Name=GluR6 Beta2; IsoId=P39087-1; Sequence=Displayed; Name=GluR6-2; IsoId=P39087-2; Sequence=VSP_000133; Most abundant in the cerebellum and the hypothalamus. Expressed in a proportion of dorsal root ganglion (DRG) neurons (13.6%); predominantly small diameter DRG neurons (75%) with the remainder expressed in medium diameter DRG neurons (PubMed:31474366). Expressed during brain development. Expression drops in the adult. Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1 (By similarity). Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome (By similarity). Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation. Modified_positions=567 , 571 , 621 ote=Partially edited. The presence of Gln at position 621 (non-edited) determines channels with low calcium permeability, whereas Arg (edited) determines a higher calcium permeability especially if the preceding sites are fully edited (By similarity). ; The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > quisqualate > 6- cyano-7-nitroquinoxaline-2,3-dione > L-glutamate = 6,7- dinitroquinoxaline-2,3-dione > dihydrokainate (By similarity). Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily. behavioral fear response ionotropic glutamate receptor activity ion channel activity extracellular-glutamate-gated ion channel activity protein binding cell plasma membrane integral component of plasma membrane ion transport cellular calcium ion homeostasis intracellular protein transport chemical synaptic transmission glutamate receptor activity ionotropic glutamate receptor complex postsynaptic density ligand-gated ion channel activity kainate selective glutamate receptor activity membrane integral component of membrane neuronal action potential cell junction PDZ domain binding axon dendrite ubiquitin conjugating enzyme binding ubiquitin protein ligase binding dendrite cytoplasm kainate selective glutamate receptor complex ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic signaling receptor activity regulation of membrane potential presynaptic membrane identical protein binding protein homodimerization activity neuronal cell body receptor clustering terminal bouton perikaryon negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process synapse postsynaptic membrane regulation of JNK cascade regulation of long-term neuronal synaptic plasticity regulation of short-term neuronal synaptic plasticity modulation of synaptic transmission positive regulation of synaptic transmission neuron apoptotic process negative regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential inhibitory postsynaptic potential postsynapse postsynaptic density membrane glutamatergic synapse regulation of presynaptic membrane potential ligand-gated ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential uc007fah.1 uc007fah.2 uc007fah.3 uc007fah.4 
ENSMUST00000218830.2 Gm36595 ENSMUST00000218830.2 predicted gene, 36595, transcript variant 1 (from RefSeq NR_152768.1) ENSMUST00000218830.1 NR_152768 uc007fcj.1 uc007fcj.2 uc007fcj.3 uc007fcj.1 uc007fcj.2 uc007fcj.3 
ENSMUST00000218832.2 Or2q1 ENSMUST00000218832.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF81) ENSMUST00000218832.1 Olfr450 Or2q1 Q8VF81 Q8VF81_MOUSE uc291dzb.1 uc291dzb.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291dzb.1 uc291dzb.2 
ENSMUST00000218833.2 C330004P14Rik ENSMUST00000218833.2 RIKEN cDNA C330004P14 gene (from RefSeq NR_131087.1) ENSMUST00000218833.1 NR_131087 uc007elr.1 uc007elr.2 uc007elr.1 uc007elr.2 
ENSMUST00000218837.2 Or2aj5 ENSMUST00000218837.2 olfactory receptor family 2 subfamily AJ member 5 (from RefSeq NM_146957.1) ENSMUST00000218837.1 NM_146957 Olfr170 Or2aj5 Q8VGL6 Q8VGL6_MOUSE uc289dhr.1 uc289dhr.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC132585.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289dhr.1 uc289dhr.2 
ENSMUST00000218840.2 Gm40617 ENSMUST00000218840.2 predicted gene, 40617 (from RefSeq NR_166644.1) ENSMUST00000218840.1 NR_166644 uc287qdd.1 uc287qdd.2 uc287qdd.1 uc287qdd.2 
ENSMUST00000218842.2 Thap2 ENSMUST00000218842.2 THAP domain containing, apoptosis associated protein 2 (from RefSeq NM_025780.4) ENSMUST00000218842.1 NM_025780 Q9D305 THAP2_MOUSE uc007hbe.1 uc007hbe.2 uc007hbe.3 molecular_function nucleic acid binding DNA binding nucleolus biological_process metal ion binding uc007hbe.1 uc007hbe.2 uc007hbe.3 
ENSMUST00000218843.2 Krtap10-10 ENSMUST00000218843.2 keratin associated protein 10-10 (from RefSeq NM_001024709.3) A0A1W2P7T6 A0A1W2P7T6_MOUSE ENSMUST00000218843.1 Krtap10-10 NM_001024709 uc007fwf.1 uc007fwf.2 uc007fwf.3 uc007fwf.4 cellular_component intermediate filament biological_process identical protein binding keratin filament uc007fwf.1 uc007fwf.2 uc007fwf.3 uc007fwf.4 
ENSMUST00000218845.2 Gm48542 ENSMUST00000218845.2 Gm48542 (from geneSymbol) ENSMUST00000218845.1 uc288gfk.1 uc288gfk.2 uc288gfk.1 uc288gfk.2 
ENSMUST00000218865.2 Or13a25 ENSMUST00000218865.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRT1) ENSMUST00000218865.1 Olfr539 Or13a25 Q7TRT1 Q7TRT1_MOUSE uc291wvq.1 uc291wvq.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291wvq.1 uc291wvq.2 
ENSMUST00000218869.3 Gm35188 ENSMUST00000218869.3 Gm35188 (from geneSymbol) ENSMUST00000218869.1 ENSMUST00000218869.2 uc288ghs.1 uc288ghs.2 uc288ghs.3 uc288ghs.1 uc288ghs.2 uc288ghs.3 
ENSMUST00000218879.2 Srp54c ENSMUST00000218879.2 signal recognition particle 54C, transcript variant 2 (from RefSeq NM_001377038.1) E9PXC0 E9PXC0_MOUSE ENSMUST00000218879.1 NM_001377038 Srp54c uc007nok.1 uc007nok.2 uc007nok.3 uc007nok.4 uc007nok.5 Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA. Cytoplasm cleus speckle Endoplasmic reticulum The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins. The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. Belongs to the GTP-binding SRP family. SRP54 subfamily. nucleotide binding molecular_function RNA binding GTPase activity GTP binding cellular_component cytoplasm signal recognition particle, endoplasmic reticulum targeting SRP-dependent cotranslational protein targeting to membrane biological_process 7S RNA binding protein targeting to ER signal recognition particle uc007nok.1 uc007nok.2 uc007nok.3 uc007nok.4 uc007nok.5 
ENSMUST00000218882.2 ENSMUSG00000121726 ENSMUST00000218882.2 ENSMUSG00000121726 (from geneSymbol) ENSMUST00000218882.1 uc288enh.1 uc288enh.2 uc288enh.1 uc288enh.2 
ENSMUST00000218893.2 Mrpl42 ENSMUST00000218893.2 mitochondrial ribosomal protein L42, transcript variant 2 (from RefSeq NM_001359476.1) D10Ertd322e ENSMUST00000218893.1 Mrps32 NM_001359476 Q9CPV3 RM42_MOUSE uc007gwj.1 uc007gwj.2 uc007gwj.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Mitochondrion Belongs to the mitochondrion-specific ribosomal protein mL42 family. Has been found in the mitochondrial ribosome large and small subunits. mitochondrion mitochondrial large ribosomal subunit mitochondrial small ribosomal subunit ribosome plasma membrane biological_process uc007gwj.1 uc007gwj.2 uc007gwj.3 
ENSMUST00000218902.3 Gm35533 ENSMUST00000218902.3 Gm35533 (from geneSymbol) ENSMUST00000218902.1 ENSMUST00000218902.2 uc287umg.1 uc287umg.2 uc287umg.3 uc287umg.1 uc287umg.2 uc287umg.3 
ENSMUST00000218906.2 Or2bd2 ENSMUST00000218906.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQV3) AK029628 ENSMUST00000218906.1 Olfr1344 Or2bd2 Q7TQV3 Q7TQV3_MOUSE uc291lbx.1 uc291lbx.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291lbx.1 uc291lbx.2 
ENSMUST00000218912.2 Gm47637 ENSMUST00000218912.2 Gm47637 (from geneSymbol) AK053553 ENSMUST00000218912.1 uc287rfd.1 uc287rfd.2 uc287rfd.1 uc287rfd.2 
ENSMUST00000218916.2 Gm47532 ENSMUST00000218916.2 Gm47532 (from geneSymbol) ENSMUST00000218916.1 uc287uwx.1 uc287uwx.2 uc287uwx.1 uc287uwx.2 
ENSMUST00000218917.2 Gm48780 ENSMUST00000218917.2 Gm48780 (from geneSymbol) AK134023 ENSMUST00000218917.1 uc288hku.1 uc288hku.2 uc288hku.1 uc288hku.2 
ENSMUST00000218922.2 Alyreffm6 ENSMUST00000218922.2 predicted gene 4303 (from RefSeq NM_001166638.1) B2RY44 E9PZY4 E9PZY4_MOUSE EG667568 ENSMUST00000218922.1 Gm4303 Gm4305 Gm4307 NM_001166638 uc057kjl.1 uc057kjl.2 molecular_function nucleic acid binding RNA binding cellular_component biological_process uc057kjl.1 uc057kjl.2 
ENSMUST00000218925.3 Gm40650 ENSMUST00000218925.3 predicted gene, 40650 (from RefSeq NR_169148.1) ENSMUST00000218925.1 ENSMUST00000218925.2 NR_169148 uc287rfs.1 uc287rfs.2 uc287rfs.3 uc287rfs.1 uc287rfs.2 uc287rfs.3 
ENSMUST00000218937.2 Gm47434 ENSMUST00000218937.2 Gm47434 (from geneSymbol) ENSMUST00000218937.1 uc287vdc.1 uc287vdc.2 uc287vdc.1 uc287vdc.2 
ENSMUST00000218939.2 Gm3055 ENSMUST00000218939.2 predicted gene 3055, transcript variant 1 (from RefSeq NM_001346707.1) BC062127 ENSMUST00000218939.1 Gm3055 NM_001346707 Q0P5U5 Q0P5U5_MOUSE Zfp781 uc287tml.1 uc287tml.2 Nucleus molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process uc287tml.1 uc287tml.2 
ENSMUST00000218941.3 Gm31267 ENSMUST00000218941.3 Gm31267 (from geneSymbol) ENSMUST00000218941.1 ENSMUST00000218941.2 uc287uxj.1 uc287uxj.2 uc287uxj.3 uc287uxj.1 uc287uxj.2 uc287uxj.3 
ENSMUST00000218944.3 Gm40652 ENSMUST00000218944.3 Gm40652 (from geneSymbol) ENSMUST00000218944.1 ENSMUST00000218944.2 uc287rhy.1 uc287rhy.2 uc287rhy.3 uc287rhy.1 uc287rhy.2 uc287rhy.3 
ENSMUST00000218957.2 Gm48751 ENSMUST00000218957.2 Gm48751 (from geneSymbol) AK028286 ENSMUST00000218957.1 uc287plh.1 uc287plh.2 uc287plh.1 uc287plh.2 
ENSMUST00000218959.3 Gm47823 ENSMUST00000218959.3 Gm47823 (from geneSymbol) ENSMUST00000218959.1 ENSMUST00000218959.2 uc287qkg.1 uc287qkg.2 uc287qkg.3 uc287qkg.1 uc287qkg.2 uc287qkg.3 
ENSMUST00000218960.2 Gm48022 ENSMUST00000218960.2 Gm48022 (from geneSymbol) ENSMUST00000218960.1 uc287sai.1 uc287sai.2 uc287sai.1 uc287sai.2 
ENSMUST00000218961.3 Gm47900 ENSMUST00000218961.3 Gm47900 (from geneSymbol) ENSMUST00000218961.1 ENSMUST00000218961.2 uc287ruu.1 uc287ruu.2 uc287ruu.3 uc287ruu.1 uc287ruu.2 uc287ruu.3 
ENSMUST00000218963.2 Gm48276 ENSMUST00000218963.2 Gm48276 (from geneSymbol) AK036766 ENSMUST00000218963.1 uc287sjv.1 uc287sjv.2 uc287sjv.1 uc287sjv.2 
ENSMUST00000218979.2 Gm48680 ENSMUST00000218979.2 Gm48680 (from geneSymbol) ENSMUST00000218979.1 uc287pnx.1 uc287pnx.2 uc287pnx.1 uc287pnx.2 
ENSMUST00000218986.2 Gm48298 ENSMUST00000218986.2 Gm48298 (from geneSymbol) AB335563 ENSMUST00000218986.1 uc287urm.1 uc287urm.2 uc287urm.1 uc287urm.2 
ENSMUST00000218987.2 Gm47582 ENSMUST00000218987.2 Gm47582 (from geneSymbol) AK050590 ENSMUST00000218987.1 uc287vie.1 uc287vie.2 uc287vie.1 uc287vie.2 
ENSMUST00000218993.2 4921515L22Rik ENSMUST00000218993.2 4921515L22Rik (from geneSymbol) AK014901 ENSMUST00000218993.1 uc287twi.1 uc287twi.2 uc287twi.1 uc287twi.2 
ENSMUST00000218999.2 Gm47573 ENSMUST00000218999.2 Gm47573 (from geneSymbol) ENSMUST00000218999.1 uc287tnl.1 uc287tnl.2 uc287tnl.1 uc287tnl.2 
ENSMUST00000219006.2 4930543I11Rik ENSMUST00000219006.2 4930543I11Rik (from geneSymbol) AK016030 ENSMUST00000219006.1 uc287rwg.1 uc287rwg.2 uc287rwg.1 uc287rwg.2 
ENSMUST00000219008.2 Gm47992 ENSMUST00000219008.2 Gm47992 (from geneSymbol) AK040658 ENSMUST00000219008.1 uc287soz.1 uc287soz.2 uc287soz.1 uc287soz.2 
ENSMUST00000219013.2 Gm47572 ENSMUST00000219013.2 Gm47572 (from geneSymbol) ENSMUST00000219013.1 uc287tnk.1 uc287tnk.2 uc287tnk.1 uc287tnk.2 
ENSMUST00000219017.3 1700042O05Rik ENSMUST00000219017.3 1700042O05Rik (from geneSymbol) AK006689 ENSMUST00000219017.1 ENSMUST00000219017.2 uc287rdo.1 uc287rdo.2 uc287rdo.3 uc287rdo.1 uc287rdo.2 uc287rdo.3 
ENSMUST00000219020.2 Gm48278 ENSMUST00000219020.2 Gm48278 (from geneSymbol) ENSMUST00000219020.1 uc287pmf.1 uc287pmf.2 uc287pmf.1 uc287pmf.2 
ENSMUST00000219025.2 Gm48077 ENSMUST00000219025.2 Gm48077 (from geneSymbol) AK139348 ENSMUST00000219025.1 uc287rmz.1 uc287rmz.2 uc287rmz.1 uc287rmz.2 
ENSMUST00000219031.2 Gm48532 ENSMUST00000219031.2 Gm48532 (from geneSymbol) AK047307 ENSMUST00000219031.1 uc288est.1 uc288est.2 uc288est.1 uc288est.2 
ENSMUST00000219032.2 Gm38403 ENSMUST00000219032.2 predicted gene, 38403 (from RefSeq NR_110482.1) ENSMUST00000219032.1 NR_110482 uc033fsu.1 uc033fsu.2 uc033fsu.1 uc033fsu.2 
ENSMUST00000219034.2 Gm48226 ENSMUST00000219034.2 Gm48226 (from geneSymbol) AK017831 ENSMUST00000219034.1 uc057bbs.1 uc057bbs.2 uc057bbs.1 uc057bbs.2 
ENSMUST00000219037.2 Cnpy2 ENSMUST00000219037.2 canopy FGF signaling regulator 2 (from RefSeq NM_019953.1) CNPY2_MOUSE ENSMUST00000219037.1 Msap NM_019953 Q3UBH8 Q9QXT0 Tmem4 Zsig9 uc007hmi.1 uc007hmi.2 uc007hmi.3 Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity). Interacts with MYLIP/MIR. Q9QXT0; Q9Z2B5: Eif2ak3; NbExp=7; IntAct=EBI-8321111, EBI-1226344; Q9QXT0; P11021: HSPA5; Xeno; NbExp=2; IntAct=EBI-8321111, EBI-354921; Endoplasmic reticulum Belongs to the canopy family. molecular_function protein binding endoplasmic reticulum negative regulation of gene expression regulation of low-density lipoprotein particle clearance positive regulation of low-density lipoprotein particle receptor biosynthetic process uc007hmi.1 uc007hmi.2 uc007hmi.3 
ENSMUST00000219040.2 Gm47353 ENSMUST00000219040.2 Gm47353 (from geneSymbol) ENSMUST00000219040.1 uc287rad.1 uc287rad.2 uc287rad.1 uc287rad.2 
ENSMUST00000219046.2 Gm47958 ENSMUST00000219046.2 Gm47958 (from geneSymbol) ENSMUST00000219046.1 uc287vcu.1 uc287vcu.2 uc287vcu.1 uc287vcu.2 
ENSMUST00000219056.2 Gm47531 ENSMUST00000219056.2 Gm47531 (from geneSymbol) ENSMUST00000219056.1 uc287rvs.1 uc287rvs.2 uc287rvs.1 uc287rvs.2 
ENSMUST00000219061.2 Gm31182 ENSMUST00000219061.2 Gm31182 (from geneSymbol) ENSMUST00000219061.1 uc287uxh.1 uc287uxh.2 uc287uxh.1 uc287uxh.2 
ENSMUST00000219062.4 Gm20337 ENSMUST00000219062.4 predicted gene, 20337 (from RefSeq NR_045057.1) ENSMUST00000219062.1 ENSMUST00000219062.2 ENSMUST00000219062.3 NR_045057 uc007obl.1 uc007obl.2 uc007obl.3 uc007obl.4 uc007obl.5 uc007obl.6 uc007obl.1 uc007obl.2 uc007obl.3 uc007obl.4 uc007obl.5 uc007obl.6 
ENSMUST00000219067.2 Gm48206 ENSMUST00000219067.2 Gm48206 (from geneSymbol) ENSMUST00000219067.1 uc287ura.1 uc287ura.2 uc287ura.1 uc287ura.2 
ENSMUST00000219077.2 C030006N10Rik ENSMUST00000219077.2 C030006N10Rik (from geneSymbol) AK021051 ENSMUST00000219077.1 uc287qjz.1 uc287qjz.2 uc287qjz.1 uc287qjz.2 
ENSMUST00000219078.2 Gm48285 ENSMUST00000219078.2 Gm48285 (from geneSymbol) ENSMUST00000219078.1 uc288gqa.1 uc288gqa.2 uc288gqa.1 uc288gqa.2 
ENSMUST00000219081.2 Gm47634 ENSMUST00000219081.2 Gm47634 (from geneSymbol) AK145326 ENSMUST00000219081.1 uc287qae.1 uc287qae.2 uc287qae.1 uc287qae.2 
ENSMUST00000219088.3 Gm47808 ENSMUST00000219088.3 Gm47808 (from geneSymbol) ENSMUST00000219088.1 ENSMUST00000219088.2 uc288exs.1 uc288exs.2 uc288exs.1 uc288exs.2 
ENSMUST00000219095.2 A430028G04Rik ENSMUST00000219095.2 A430028G04Rik (from geneSymbol) AK040114 ENSMUST00000219095.1 uc287vic.1 uc287vic.2 uc287vic.1 uc287vic.2 
ENSMUST00000219103.2 Gm48115 ENSMUST00000219103.2 Gm48115 (from geneSymbol) ENSMUST00000219103.1 uc287vez.1 uc287vez.2 uc287vez.1 uc287vez.2 
ENSMUST00000219108.2 Ttc41 ENSMUST00000219108.2 tetratricopeptide repeat domain 41, transcript variant 2 (from RefSeq NM_153595.3) A0A1W2P894 A0A1W2P894_MOUSE ENSMUST00000219108.1 NM_153595 Ttc41 uc007gql.1 uc007gql.2 uc007gql.3 uc007gql.4 uc007gql.1 uc007gql.2 uc007gql.3 uc007gql.4 
ENSMUST00000219109.2 Rab3ip ENSMUST00000219109.2 RAB3A interacting protein, transcript variant 1 (from RefSeq NM_001359645.1) A0A1W2P7K6 A0A1W2P7K6_MOUSE ENSMUST00000219109.1 NM_001359645 Rab3ip uc007hck.1 uc007hck.2 uc007hck.3 Belongs to the SEC2 family. guanyl-nucleotide exchange factor activity uc007hck.1 uc007hck.2 uc007hck.3 
ENSMUST00000219110.2 Gm6993 ENSMUST00000219110.2 Lipid metabolism; sphingolipid metabolism. (from UniProt A0A1W2P738) A0A1W2P738 A0A1W2P738_MOUSE ENSMUST00000219110.1 Gm6993 uc288fta.1 uc288fta.2 Lipid metabolism; sphingolipid metabolism. Sphingolipid metabolism. Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the SPTSS family. SPTSSA subfamily. molecular_function cellular_component biological_process membrane integral component of membrane uc288fta.1 uc288fta.2 
ENSMUST00000219111.2 Or52h7 ENSMUST00000219111.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt B9EHE6) B9EHE6 B9EHE6_MOUSE ENSMUST00000219111.1 Olfr652 Or52h7 uc291tuh.1 uc291tuh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tuh.1 uc291tuh.2 
ENSMUST00000219113.2 Gm47101 ENSMUST00000219113.2 Gm47101 (from geneSymbol) ENSMUST00000219113.1 uc287uov.1 uc287uov.2 uc287uov.1 uc287uov.2 
ENSMUST00000219114.2 Gm47594 ENSMUST00000219114.2 Gm47594 (from geneSymbol) ENSMUST00000219114.1 uc287rnj.1 uc287rnj.2 uc287rnj.1 uc287rnj.2 
ENSMUST00000219124.2 Gm48203 ENSMUST00000219124.2 Gm48203 (from geneSymbol) ENSMUST00000219124.1 uc287urc.1 uc287urc.2 uc287urc.1 uc287urc.2 
ENSMUST00000219127.2 Gm47096 ENSMUST00000219127.2 Gm47096 (from geneSymbol) ENSMUST00000219127.1 uc288gdi.1 uc288gdi.2 uc288gdi.1 uc288gdi.2 
ENSMUST00000219140.3 Mia2 ENSMUST00000219140.3 MIA SH3 domain ER export factor 2, transcript variant 6 (from RefSeq NM_001368839.1) A0A1W2P711 A0A1W2P711_MOUSE ENSMUST00000219140.1 ENSMUST00000219140.2 Mia2 NM_001368839 uc288gou.1 uc288gou.2 This gene encodes a protein that is involved in endoplasmic reticulum-to-Golgi trafficking and regulation of cholesterol metabolism. Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species. Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding diverse isoforms. A mutation in this gene (couch-potato or cpto) may result in low levels of plasma cholesterol and triglycerides. [provided by RefSeq, Sep 2016]. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849380, SAMN00849381 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## Endoplasmic reticulum membrane ; Single-pass membrane protein Membrane ; Single-pass membrane protein membrane integral component of membrane uc288gou.1 uc288gou.2 
ENSMUST00000219142.3 1700022H01Rik ENSMUST00000219142.3 RIKEN cDNA 1700022H01 gene (from RefSeq NR_126477.1) ENSMUST00000219142.1 ENSMUST00000219142.2 NR_126477 uc007fgf.1 uc007fgf.2 uc007fgf.3 uc007fgf.4 uc007fgf.5 uc007fgf.1 uc007fgf.2 uc007fgf.3 uc007fgf.4 uc007fgf.5 
ENSMUST00000219144.2 Zfp781b ENSMUST00000219144.2 zinc finger protein 781, transcript variant 2 (from RefSeq NM_199062.2) BC062127 ENSMUST00000219144.1 Gm3055 NM_199062 Q0P5U5 Q0P5U5_MOUSE Zfp781 uc011xjn.1 uc011xjn.2 Nucleus molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process uc011xjn.1 uc011xjn.2 
ENSMUST00000219147.2 Cdc5lrt1 ENSMUST00000219147.2 Belongs to the CEF1 family. (from UniProt A0A1W2P7S8) A0A1W2P7S8 A0A1W2P7S8_MOUSE Cdc5lrt1 Cdc5lrt4 ENSMUST00000219147.1 Gm32717 Gm32802 LF198247 uc029rgi.1 uc029rgi.2 uc029rgi.3 Belongs to the CEF1 family. DNA binding uc029rgi.1 uc029rgi.2 uc029rgi.3 
ENSMUST00000219148.2 Gm47917 ENSMUST00000219148.2 Gm47917 (from geneSymbol) ENSMUST00000219148.1 uc287rgz.1 uc287rgz.2 uc287rgz.1 uc287rgz.2 
ENSMUST00000219153.2 3110043J17Rik ENSMUST00000219153.2 3110043J17Rik (from geneSymbol) AK014172 ENSMUST00000219153.1 uc287utl.1 uc287utl.2 uc287utl.1 uc287utl.2 
ENSMUST00000219154.2 Gm47459 ENSMUST00000219154.2 Gm47459 (from geneSymbol) ENSMUST00000219154.1 uc287sqm.1 uc287sqm.2 uc287sqm.1 uc287sqm.2 
ENSMUST00000219159.2 Alyreffm7 ENSMUST00000219159.2 predicted gene 4305 (from RefSeq NM_001166639.1) B2RY44 E9PZY4 E9PZY4_MOUSE EG667568 ENSMUST00000219159.1 Gm4303 Gm4305 Gm4307 NM_001166639 uc057kjm.1 uc057kjm.2 molecular_function nucleic acid binding RNA binding cellular_component biological_process uc057kjm.1 uc057kjm.2 
ENSMUST00000219161.2 Gm47022 ENSMUST00000219161.2 Gm47022 (from geneSymbol) AK153756 ENSMUST00000219161.1 uc287rbd.1 uc287rbd.2 uc287rbd.1 uc287rbd.2 
ENSMUST00000219164.2 Gm47472 ENSMUST00000219164.2 Gm47472 (from geneSymbol) ENSMUST00000219164.1 uc287utd.1 uc287utd.2 uc287utd.1 uc287utd.2 
ENSMUST00000219167.2 4930503E24Rik ENSMUST00000219167.2 RIKEN cDNA 4930503E24 gene (from RefSeq NR_028310.1) ENSMUST00000219167.1 NR_028310 uc011xpg.1 uc011xpg.2 uc011xpg.1 uc011xpg.2 
ENSMUST00000219168.2 Gm48341 ENSMUST00000219168.2 Gm48341 (from geneSymbol) ENSMUST00000219168.1 uc287vfs.1 uc287vfs.2 uc287vfs.1 uc287vfs.2 
ENSMUST00000219183.2 Hsd17b6 ENSMUST00000219183.2 hydroxysteroid (17-beta) dehydrogenase 6, transcript variant 2 (from RefSeq NM_001359377.1) ENSMUST00000219183.1 Gm182 H17B6_MOUSE Hsd17b9 NM_001359377 Q9R092 Rdh8 uc007hkz.1 uc007hkz.2 uc007hkz.3 NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17- beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Reaction=all-trans-retinol--[retinol-binding protein] + NAD(+) = all- trans-retinal--[retinol-binding protein] + H(+) + NADH; Xref=Rhea:RHEA:48488, Rhea:RHEA-COMP:14428, Rhea:RHEA-COMP:14430, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83228; EC=1.1.1.105; Evidence=; Reaction=all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH; Xref=Rhea:RHEA:21284, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.105; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21285; Evidence=; Reaction=androsterone + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:20381, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:16032, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.209; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20382; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:20383; Evidence=; Reaction=NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:14929, ChEBI:CHEBI:15378, ChEBI:CHEBI:16422, ChEBI:CHEBI:17347, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.239; Evidence=; Reaction=5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta- hydroxy-5alpha-androstan-3-one + H(+) + NADH; Xref=Rhea:RHEA:42004, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:36713, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.53; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42006; Evidence=; Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence=; Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH; Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62; Evidence=; Reaction=3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) = 5alpha- pregnane-3,20-dione + H(+) + NADH; Xref=Rhea:RHEA:41980, ChEBI:CHEBI:15378, ChEBI:CHEBI:28952, ChEBI:CHEBI:50169, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41981; Evidence=; Reaction=5alpha-androstane-3beta,17beta-diol + NAD(+) = 17beta-hydroxy- 5alpha-androstan-3-one + H(+) + NADH; Xref=Rhea:RHEA:42184, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:18329, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42186; Evidence=; Reaction=3beta-hydroxy-5alpha-androstan-17-one + NAD(+) = 5alpha- androstan-3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:42188, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:541975; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42190; Evidence=; Inhibited by carbenoxolone and phenyl arsenoxide. Kinetic parameters: KM=1.4 uM for 5-alpha-androstan-3-alpha,17-beta-diol ; KM=1.3 uM for androsterone ; KM=3.2 uM for all-trans-retinol ; KM=1.5 uM for estradiol ; Vmax=2.8 nmol/min/mg enzyme for 5-alpha-androstan-3-alpha,17-beta- diol ; Vmax=1.1 nmol/min/mg enzyme for androsterone ; Vmax=0.4 nmol/min/mg enzyme for all-trans-retinol ; Vmax=2.3 nmol/min/mg enzyme for estradiol ; pH dependence: Optimum pH is 8.5-9.5. ; Microsome membrane ; Peripheral membrane protein ; Lumenal side Early endosome membrane ; Peripheral membrane protein ; Lumenal side Detected in liver. Belongs to the short-chain dehydrogenases/reductases (SDR) family. estradiol 17-beta-dehydrogenase activity retinol dehydrogenase activity endosome endoplasmic reticulum lipid metabolic process steroid metabolic process membrane oxidoreductase activity organelle membrane early endosome membrane intracellular membrane-bounded organelle testosterone dehydrogenase (NAD+) activity oxidation-reduction process uc007hkz.1 uc007hkz.2 uc007hkz.3 
ENSMUST00000219186.3 Gm35404 ENSMUST00000219186.3 Gm35404 (from geneSymbol) ENSMUST00000219186.1 ENSMUST00000219186.2 uc287vfz.1 uc287vfz.2 uc287vfz.3 uc287vfz.1 uc287vfz.2 uc287vfz.3 
ENSMUST00000219190.2 Gm48426 ENSMUST00000219190.2 Gm48426 (from geneSymbol) AK131769 ENSMUST00000219190.1 uc287vfx.1 uc287vfx.2 uc287vfx.1 uc287vfx.2 
ENSMUST00000219196.2 Gm48074 ENSMUST00000219196.2 Gm48074 (from geneSymbol) AK052793 ENSMUST00000219196.1 uc287rna.1 uc287rna.2 uc287rna.1 uc287rna.2 
ENSMUST00000219198.2 Gm32828 ENSMUST00000219198.2 Gm32828 (from geneSymbol) AK043922 ENSMUST00000219198.1 uc007mzb.1 uc007mzb.2 uc007mzb.1 uc007mzb.2 
ENSMUST00000219218.3 Gm35101 ENSMUST00000219218.3 Gm35101 (from geneSymbol) AK039362 ENSMUST00000219218.1 ENSMUST00000219218.2 uc287ulx.1 uc287ulx.2 uc287ulx.3 uc287ulx.1 uc287ulx.2 uc287ulx.3 
ENSMUST00000219221.2 Gm38407 ENSMUST00000219221.2 predicted gene, 38407 (from RefSeq NR_110487.1) ENSMUST00000219221.1 NR_110487 uc033gcq.1 uc033gcq.2 uc033gcq.1 uc033gcq.2 
ENSMUST00000219228.2 Fgf22 ENSMUST00000219228.2 fibroblast growth factor 22, transcript variant 1 (from RefSeq NM_023304.2) ENSMUST00000219228.1 FGF22_MOUSE NM_023304 Q9ESS2 uc007fzp.1 uc007fzp.2 uc007fzp.3 Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development. Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 (By similarity). Secreted Preferentially expressed in skin; low expression in brain. Expressed in the inner root sheath of the hair follicle. Belongs to the heparin-binding growth factors family. fibroblast growth factor receptor binding protein binding nucleolus Golgi apparatus growth factor activity fibroblast growth factor receptor signaling pathway cell surface extracellular region uc007fzp.1 uc007fzp.2 uc007fzp.3 
ENSMUST00000219233.2 Gm47163 ENSMUST00000219233.2 Gm47163 (from geneSymbol) ENSMUST00000219233.1 uc287ssh.1 uc287ssh.2 uc287ssh.1 uc287ssh.2 
ENSMUST00000219235.3 Or2h1b ENSMUST00000219235.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q6UAH1) ENSMUST00000219235.1 ENSMUST00000219235.2 Olfr93 Or2h1b Q6UAH1 Q6UAH1_MOUSE uc008cmh.1 uc008cmh.2 uc008cmh.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008cmh.1 uc008cmh.2 uc008cmh.3 
ENSMUST00000219238.2 Arid5b ENSMUST00000219238.2 AT-rich interaction domain 5B (from RefSeq NM_023598.2) ARI5B_MOUSE Desrt E9Q523 ENSMUST00000219238.1 Mrf2 NM_023598 Q8BM75 Q8C0E0 Q8K4G8 Q8K4L9 Q9CU78 Q9JIX4 uc029qyp.1 uc029qyp.2 uc029qyp.3 Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver (By similarity). Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Mrf2alpha, Alpha; IsoId=Q8BM75-1; Sequence=Displayed; Name=2; Synonyms=Mrf2beta, Beta; IsoId=Q8BM75-2; Sequence=VSP_009357, VSP_009358; Name=3; IsoId=Q8BM75-3; Sequence=VSP_009359, VSP_009360; Widely expressed. Expressed in lung, heart, small intestine, kidney, muscle and brain. Also expressed in spleen, thymus, endocrine organs and in uterus and testis. First detected in the intermediate plate mesoderm, and subsequently in the nephrogenic cords of the urogenital ridges. Expressed in the developing limb. Also expressed in the myotome of the somites from 9.5 dpc, the oro-nasopharyngeal ectoderm and underlying mesenchyme, otic vesicles, the gut and its derivatives, and transiently in the liver at 11.5 dpc. During smooth muscle cell differentiation in vitro. Upon adipogenesis. The ARID domain mediates the interaction with DNA. Methylation at Lys-337 prevents DNA-binding. Demethylation by PHF2 promotes recruitment of the PHF2-ARID5B complex to promoters (By similarity). High rate of neonatal mortality. Embryonic growth or birth weight are not effected, while lipid accumulation is severely reduced in brown adipose neonates at 24 hours of age. Mice weigh significantly less than controls from postnatal day 5 onward. Adult mice are lean, with significant reductions in brown and white adipose tissues, and in the percentage of body fat. Mice are also resistant to weight gains and obesity when maintained on high-fat diets. Belongs to the ARID5B family. Sequence=AAF89682.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=AAF89682.1; Type=Frameshift; Evidence=; Sequence=BAC28778.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding kidney development DNA binding transcription coactivator activity nucleus regulation of transcription from RNA polymerase II promoter nitrogen compound metabolic process male gonad development female gonad development post-embryonic development fibroblast migration adrenal gland development multicellular organism growth transcription regulatory region DNA binding fat cell differentiation platelet-derived growth factor receptor signaling pathway cell development muscle organ morphogenesis skeletal system morphogenesis positive regulation of sequence-specific DNA binding transcription factor activity palate development face morphogenesis adipose tissue development fat pad development positive regulation of nucleic acid-templated transcription cellular response to leukemia inhibitory factor uc029qyp.1 uc029qyp.2 uc029qyp.3 
ENSMUST00000219248.2 ENSMUSG00000121448 ENSMUST00000219248.2 ENSMUSG00000121448 (from geneSymbol) ENSMUST00000219248.1 uc287spt.1 uc287spt.2 uc287spt.1 uc287spt.2 
ENSMUST00000219260.2 Sbno2 ENSMUST00000219260.2 Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions (PubMed:18025162, PubMed:23980096). Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC- STAMP promoter in osteoclast (PubMed:23980096). Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL- mediated osteoclast fusion via a DCSTAMP-dependent pathway (PubMed:23980096). May also be required in the regulation of osteoblast differentiation (PubMed:23980096). Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the pro-inflammatory cascade (By similarity). (from UniProt Q7TNB8) AJ512611 ENSMUST00000219260.1 Q3UE14 Q6P3A3 Q70X02 Q7TNB8 SBNO2_MOUSE Sno Stno uc007gbn.1 uc007gbn.2 uc007gbn.3 Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions (PubMed:18025162, PubMed:23980096). Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC- STAMP promoter in osteoclast (PubMed:23980096). Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL- mediated osteoclast fusion via a DCSTAMP-dependent pathway (PubMed:23980096). May also be required in the regulation of osteoblast differentiation (PubMed:23980096). Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the pro-inflammatory cascade (By similarity). Interacts with TAL1; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF (PubMed:23980096). Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7TNB8-1; Sequence=Displayed; Name=2; IsoId=Q7TNB8-2; Sequence=VSP_030309; Name=3; IsoId=Q7TNB8-3; Sequence=VSP_030305, VSP_030306, VSP_030307, VSP_030308; Expressed in the spleen and bone marrow, and to a lesser extent in the kidney, liver, brain, skin, heart and muscle (PubMed:23980096). Expressed predominantly in osteoclasts, and to a lesser extent in T-cells, B-cells and osteoblasts (PubMed:23980096). Expressed in macrophages (PubMed:18025162). Up-regulated by interleukin IL6 together with soluble interleukin receptor IL6R in astrocytes (PubMed:25903009). Up-regulated by interleukins such as IL1B or tumor necrosis factor TNF in astrocytes (at protein level) (PubMed:25903009). Up-regulated also by other cytokines such as interleukin IL11, oncostatin M (OSM) and leukemia inhibitory factor (LIF) (PubMed:25903009). Up-regulated by lipopolysaccharide (LPS) (PubMed:25903009, PubMed:23980096). Up- regulated by interleukin IL10 in a STAT3-dependent manner in bone marrow derived macrophages (PubMed:18025162). Up-regulated by TNFSF11//RANKL in a c-Fos/FOS-dependent manner (PubMed:23980096). Mice display a severe osteopetrotic phenotype characterized with an increased bone mass (PubMed:23980096). Show a reduction in the osteoclast surface/bone surface and eroded surface/bone surface ratio, but the osteoclast number/bone surface ratio is normal (PubMed:23980096). Show also a reduction in nuclei/osteoclast ratio (PubMed:23980096). Exhibit an impairment in TNFSF11//RANKL-mediated osteoclast fusion (PubMed:23980096). Show a slight inhibition of osteoblast differentiation (PubMed:23980096). Belongs to the SBNO family. ossification macrophage activation involved in immune response protein binding cellular_component nucleus regulation of transcription, DNA-templated cell differentiation bone mineralization osteoclast differentiation chromatin DNA binding histone binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of inflammatory response bone trabecula morphogenesis cellular response to lipopolysaccharide cellular response to interleukin-11 cellular response to interleukin-6 multinuclear osteoclast differentiation osteoclast fusion cellular response to leukemia inhibitory factor uc007gbn.1 uc007gbn.2 uc007gbn.3 
ENSMUST00000219261.2 Or5bb12 ENSMUST00000219261.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A140LHT7) A0A140LHT7 A0A140LHT7_MOUSE ENSMUST00000219261.1 Olfr1555 Or5bb12 uc289rbc.1 uc289rbc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rbc.1 uc289rbc.2 
ENSMUST00000219263.2 Ppp1r12a ENSMUST00000219263.2 protein phosphatase 1, regulatory subunit 12A, transcript variant 3 (from RefSeq NM_001368737.1) ENSMUST00000219263.1 MYPT1_MOUSE Mypt1 NM_001368737 Ppp1r12a Q05A74 Q8CBV2 Q99NB6 Q9DBR7 uc287uso.1 uc287uso.2 Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity (By similarity). PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12A mediates binding to myosin. Interacts with ARHA and CIT (By similarity). Binds PPP1R12B, ROCK1 and IL16. Interacts directly with PRKG1. Non-covalent dimer of 2 dimers; PRKG1-PRKG1 and PPP1R12A-PPP1R12A. Interacts with SMTNL1 (By similarity). Interacts with PPP1CB; the interaction is direct. Interacts (when phosphorylated at Ser-445, Ser-472 and Ser-910) with 14-3-3. Interacts with ROCK1 and ROCK2. Interacts with isoform 1 and isoform 2 of ZIPK/DAPK3. Interacts with RAF1. Interacts with HIF1AN (By similarity). Interacts with NCKAP1L (By similarity). Q9DBR7; P0C605-1: Prkg1; NbExp=2; IntAct=EBI-1014335, EBI-15699851; Cytoplasm Cytoplasm, cytoskeleton, stress fiber Note=Also along actomyosin filaments. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DBR7-1; Sequence=Displayed; Name=2; IsoId=Q9DBR7-2; Sequence=VSP_038478; Expressed in striated and vascular smooth muscle, specificcally in type 2a fibers (at protein level). Expression levels are 20-30% higher in developed males than females (at protein level). In neonates, expressed at low levels in striated and smooth muscles. As the animals mature sexually, expression increases 10-20-fold. Pregnancy promotes a 2-3-fold increase in expression in striated, vascular and uterine muscle (at protein level). Expressed in the prosencephalic neural folds at 8.5 dpc. Expressed in the lower urinary tract, specifically in epitheliumof the bladder, urethra, and genital tubercle at 13.5 dpc (PubMed:31883643). Heterotetramerization is mediated by the interaction between a coiled-coil of PRKG1 and the leucine/isoleucine zipper of PPP1R12A/MBS, the myosin-binding subunit of the myosin phosphatase. The KVKF motif mediates interaction with PPP1CB. Phosphorylated by CIT (Rho-associated kinase) (By similarity). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-694 (By similarity). Phosphorylated on upon DNA damage, probably by ATM or ATR. In vitro, phosphorylation of Ser-693 by PKA and PKG appears to prevent phosphorylation of the inhibitory site Thr-694, probably mediated by PRKG1. Phosphorylation at Ser-445, Ser-472 and Ser-909 by NUAK1 promotes interaction with 14-3-3, leading to inhibit interaction with myosin light chain MLC2, preventing dephosphorylation of MLC2. May be phosphorylated at Thr-694 by DMPK; may inhibit the myosin phosphatase activity (By similarity). Phosphorylated at Ser-473 by CDK1 during mitosis, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates PPP1R12A (By similarity). mitotic cell cycle kinetochore enzyme inhibitor activity protein binding cytoplasm centrosome cytosol cytoskeleton protein dephosphorylation centrosome cycle signal transduction actin cytoskeleton phosphatase regulator activity protein kinase binding Z disc regulation of cell adhesion A band regulation of myosin-light-chain-phosphatase activity positive regulation of myosin-light-chain-phosphatase activity cellular response to drug negative regulation of catalytic activity contractile fiber positive regulation of transcription from RNA polymerase II promoter regulation of nucleocytoplasmic transport 14-3-3 protein binding PTW/PP1 phosphatase complex uc287uso.1 uc287uso.2 
ENSMUST00000219265.2 Gm47522 ENSMUST00000219265.2 Gm47522 (from geneSymbol) ENSMUST00000219265.1 uc287uwv.1 uc287uwv.2 uc287uwv.1 uc287uwv.2 
ENSMUST00000219269.2 Gm48076 ENSMUST00000219269.2 Gm48076 (from geneSymbol) ENSMUST00000219269.1 uc288eug.1 uc288eug.2 uc288eug.1 uc288eug.2 
ENSMUST00000219276.2 Gm48363 ENSMUST00000219276.2 Gm48363 (from geneSymbol) ENSMUST00000219276.1 uc287uru.1 uc287uru.2 uc287uru.1 uc287uru.2 
ENSMUST00000219278.2 Or5bw2 ENSMUST00000219278.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VF34) ENSMUST00000219278.1 Olfr1350 Or5bw2 Q8VF34 Q8VF34_MOUSE uc291lda.1 uc291lda.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291lda.1 uc291lda.2 
ENSMUST00000219283.2 Gm47939 ENSMUST00000219283.2 Gm47939 (from geneSymbol) BC005512 ENSMUST00000219283.1 uc287qed.1 uc287qed.2 uc287qed.1 uc287qed.2 
ENSMUST00000219287.2 Gm48657 ENSMUST00000219287.2 Gm48657 (from geneSymbol) ENSMUST00000219287.1 uc287ugo.1 uc287ugo.2 uc287ugo.1 uc287ugo.2 
ENSMUST00000219291.2 Or4k36 ENSMUST00000219291.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGG8) A0A0N4SWF1 ENSMUST00000219291.1 Olfr1280 Olfr1283 Or4k36 Q8VGG8 Q8VGG8_MOUSE uc008lnh.1 uc008lnh.2 uc008lnh.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008lnh.1 uc008lnh.2 uc008lnh.3 
ENSMUST00000219293.3 Gm48024 ENSMUST00000219293.3 Gm48024 (from geneSymbol) ENSMUST00000219293.1 ENSMUST00000219293.2 uc287sal.1 uc287sal.2 uc287sal.3 uc287sal.1 uc287sal.2 uc287sal.3 
ENSMUST00000219295.2 Or10d4c ENSMUST00000219295.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EQ84) ENSMUST00000219295.1 Olfr961 Or10d4c Q9EQ84 Q9EQ84_MOUSE uc009oyi.1 uc009oyi.2 uc009oyi.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc009oyi.1 uc009oyi.2 uc009oyi.3 
ENSMUST00000219298.2 Gm48761 ENSMUST00000219298.2 Gm48761 (from geneSymbol) AK089850 ENSMUST00000219298.1 uc287uku.1 uc287uku.2 uc287uku.1 uc287uku.2 
ENSMUST00000219313.2 Gm33843 ENSMUST00000219313.2 Gm33843 (from geneSymbol) ENSMUST00000219313.1 uc287ujl.1 uc287ujl.2 uc287ujl.1 uc287ujl.2 
ENSMUST00000219317.2 Cd63 ENSMUST00000219317.2 Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. (from UniProt Q549D0) BC083161 Cd63 ENSMUST00000219317.1 Q549D0 Q549D0_MOUSE uc007hou.1 uc007hou.2 uc007hou.3 uc007hou.4 Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. Cell membrane ; Multi-pass membrane protein Cell surface Endosome membrane ; Multi-pass membrane protein Endosome, multivesicular body Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Melanosome Membrane ; Multi- pass membrane protein Belongs to the tetraspanin (TM4SF) family. positive regulation of receptor internalization extracellular space lysosomal membrane cell-matrix adhesion cell surface endosome membrane membrane integral component of membrane cell migration intrinsic component of plasma membrane late endosome membrane endosome lumen multivesicular body membrane cellular protein localization endosome to melanosome transport pigment granule maturation extracellular exosome multivesicular body, internal vesicle regulation of vascular endothelial growth factor signaling pathway regulation of potassium ion transmembrane transport positive regulation of integrin-mediated signaling pathway uc007hou.1 uc007hou.2 uc007hou.3 uc007hou.4 
ENSMUST00000219319.2 Gm35189 ENSMUST00000219319.2 Gm35189 (from geneSymbol) ENSMUST00000219319.1 uc288his.1 uc288his.2 uc288his.1 uc288his.2 
ENSMUST00000219320.2 Gm47567 ENSMUST00000219320.2 Gm47567 (from geneSymbol) ENSMUST00000219320.1 uc288ily.1 uc288ily.2 uc288ily.1 uc288ily.2 
ENSMUST00000219321.2 Gm48025 ENSMUST00000219321.2 Gm48025 (from geneSymbol) ENSMUST00000219321.1 uc287sar.1 uc287sar.2 uc287sar.1 uc287sar.2 
ENSMUST00000219324.2 Gm47593 ENSMUST00000219324.2 Gm47593 (from geneSymbol) ENSMUST00000219324.1 uc287rng.1 uc287rng.2 uc287rng.1 uc287rng.2 
ENSMUST00000219325.2 Gm47631 ENSMUST00000219325.2 Gm47631 (from geneSymbol) ENSMUST00000219325.1 uc287umu.1 uc287umu.2 uc287umu.1 uc287umu.2 
ENSMUST00000219328.2 Gm28905 ENSMUST00000219328.2 Gm28905 (from geneSymbol) ENSMUST00000219328.1 uc287pmd.1 uc287pmd.2 uc287pmd.1 uc287pmd.2 
ENSMUST00000219333.2 Gm47704 ENSMUST00000219333.2 Gm47704 (from geneSymbol) ENSMUST00000219333.1 uc287qjw.1 uc287qjw.2 uc287qjw.1 uc287qjw.2 
ENSMUST00000219339.2 4930521O17Rik ENSMUST00000219339.2 RIKEN cDNA 4930521O17 gene (from RefSeq NR_152797.1) ENSMUST00000219339.1 NR_152797 uc287rwm.1 uc287rwm.2 uc287rwm.1 uc287rwm.2 
ENSMUST00000219353.4 AI463170 ENSMUST00000219353.4 expressed sequence AI463170 (from RefSeq NR_046044.1) ENSMUST00000219353.1 ENSMUST00000219353.2 ENSMUST00000219353.3 NR_046044 uc007nyl.1 uc007nyl.2 uc007nyl.3 uc007nyl.4 uc007nyl.5 uc007nyl.6 uc007nyl.1 uc007nyl.2 uc007nyl.3 uc007nyl.4 uc007nyl.5 uc007nyl.6 
ENSMUST00000219371.2 9530020I12Rik ENSMUST00000219371.2 RIKEN cDNA 9530020I12 gene, transcript variant 2 (from RefSeq NR_131084.1) ENSMUST00000219371.1 NR_131084 uc056ypp.1 uc056ypp.2 uc056ypp.3 uc056ypp.1 uc056ypp.2 uc056ypp.3 
ENSMUST00000219375.2 Prf1 ENSMUST00000219375.2 perforin 1 (pore forming protein) (from RefSeq NM_011073.3) ENSMUST00000219375.1 NM_011073 P10820 PERF_MOUSE Pfp uc007ffv.1 uc007ffv.2 uc007ffv.3 uc007ffv.4 Pore-forming protein that plays a key role in granzyme- mediated programmed cell death, and in defense against virus-infected or neoplastic cells (PubMed:2783478, PubMed:7520535, PubMed:7972104, PubMed:19446473, PubMed:21037563, PubMed:3261391, PubMed:7526382, PubMed:8164737, PubMed:26306037, PubMed:35148176, PubMed:35705808). Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores (PubMed:19446473, PubMed:21037563, PubMed:3261391, PubMed:7526382, PubMed:8164737, PubMed:26306037, PubMed:35148176, PubMed:35705808). Promotes cytolysis and apoptosis of target cells by mediating the passage and uptake of cytotoxic granzymes (PubMed:19446473, PubMed:21037563, PubMed:3261391, PubMed:7526382, PubMed:8164737, PubMed:26306037, PubMed:35148176). Facilitates the delivery of cationic cargo protein, while anionic or neural proteins are not delivered efficiently (By similarity). Perforin pores allow the release of mature caspase-7 (CASP7) into the extracellular milieu (PubMed:35705808). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= Monomer, as soluble protein (PubMed:19446473, PubMed:21037563). Homooligomer; homooligomerizes to form a pore-forming ring (PubMed:19446473, PubMed:21037563, PubMed:35148176). Cytolytic granule creted ll membrane ulti-pass membrane protein dosome lumen Note=Released from cytotoxic lymphocytes, together with proapoptotic granzymes: stored in cytolytic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell (PubMed:2040805, PubMed:8164737). May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes (By similarity). Inserts into the cell membrane of target cells and forms pores (PubMed:19446473, PubMed:21037563). Membrane insertion and pore formation requires a major conformation change (PubMed:19446473, PubMed:21037563). Detected in cytotoxic T-lymphocytes and natural killer cells. Perforin consists of three domains: (1) the MACPF domain, which includes the central machinery of pore formation, (2) the EGF-like domain, which forms a 'shelf-like' assembly connecting the MACPF and C2 domains, and (3) the C2 domain, which mediates calcium-dependent binding to lipid membranes (PubMed:21037563, PubMed:35148176). The C2 domain is critical for initial calcium-dependent interaction with lipid membranes of the target cell: calcium-binding causes a significant structural rearrangement, leading to oligomerization and deployment of the two transmembrane beta-strands (named CH1/TMH1 and CH2/TMH2) that enter the membrane as amphipathic beta-hairpins (PubMed:21037563, PubMed:26306037, PubMed:35148176). The third calcium-binding site (Ca(2+) 3), which constitutes the weakest affinity site, triggers structural rearrangements in the C2 domain that facilitate its interaction with lipid membranes (PubMed:26306037). N-glycosylated. The glycosylation sites are facing the interior of the pore. Mice are viable and fertile, but die of virus infections that are normally efficiently dealt with by the immune system (PubMed:7526382, PubMed:8164737, PubMed:7972104, PubMed:7520535). They cannot eliminate lymphocytic choriomeningitis virus, but die of the infection (PubMed:7526382, PubMed:8164737, PubMed:7972104, PubMed:7520535). Young mice are abnormally susceptible to mouse hepatitis virus (PubMed:7526382, PubMed:8164737, PubMed:7972104, PubMed:7520535). Cytolytic activity towards tumor cells and transplants is also severely reduced (PubMed:7526382, PubMed:8164737, PubMed:7972104, PubMed:7520535). Belongs to the complement C6/C7/C8/C9 family. Name=Protein Spotlight; Note=Our hollow architecture - Issue 126 of February 2011; URL="https://web.expasy.org/spotlight/back_issues/126"; immunological synapse formation T cell mediated cytotoxicity defense response to tumor cell immune response to tumor cell calcium ion binding extracellular region extracellular space endosome cytosol plasma membrane apoptotic process circadian rhythm membrane integral component of membrane cytolysis wide pore channel activity cytoplasmic vesicle endosome lumen identical protein binding cytolytic granule metal ion binding protein homooligomerization defense response to virus positive regulation of killing of cells of other organism transmembrane transport uc007ffv.1 uc007ffv.2 uc007ffv.3 uc007ffv.4 
ENSMUST00000219379.2 Gm47599 ENSMUST00000219379.2 Gm47599 (from geneSymbol) ENSMUST00000219379.1 uc287uhu.1 uc287uhu.2 uc287uhu.1 uc287uhu.2 
ENSMUST00000219395.2 Gm46189 ENSMUST00000219395.2 Gm46189 (from geneSymbol) ENSMUST00000219395.1 uc287rci.1 uc287rci.2 uc287rci.1 uc287rci.2 
ENSMUST00000219397.2 Gm47024 ENSMUST00000219397.2 Gm47024 (from geneSymbol) ENSMUST00000219397.1 uc287vdw.1 uc287vdw.2 uc287vdw.1 uc287vdw.2 
ENSMUST00000219407.3 Gm40723 ENSMUST00000219407.3 Gm40723 (from geneSymbol) ENSMUST00000219407.1 ENSMUST00000219407.2 uc287tpr.1 uc287tpr.2 uc287tpr.3 uc287tpr.1 uc287tpr.2 uc287tpr.3 
ENSMUST00000219412.2 Or1s2 ENSMUST00000219412.2 olfactory receptor family 1 subfamily S member 1 (from RefSeq NM_146989.2) B9EHG2 B9EHG2_MOUSE ENSMUST00000219412.1 NM_146989 Olfr1496 Or1s2 uc008gvz.1 uc008gvz.2 uc008gvz.3 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: BC137878.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008gvz.1 uc008gvz.2 uc008gvz.3 
ENSMUST00000219415.3 Gm34776 ENSMUST00000219415.3 Gm34776 (from geneSymbol) ENSMUST00000219415.1 ENSMUST00000219415.2 uc287scg.1 uc287scg.2 uc287scg.3 uc287scg.1 uc287scg.2 uc287scg.3 
ENSMUST00000219416.2 Gm47712 ENSMUST00000219416.2 Gm47712 (from geneSymbol) ENSMUST00000219416.1 uc287psd.1 uc287psd.2 uc287psd.1 uc287psd.2 
ENSMUST00000219418.2 Gm48306 ENSMUST00000219418.2 Gm48306 (from geneSymbol) AK139875 ENSMUST00000219418.1 uc287twb.1 uc287twb.2 uc287twb.1 uc287twb.2 
ENSMUST00000219429.2 Sros1 ENSMUST00000219429.2 non-coding RNA suppressor of Stat1 (from RefSeq NR_040616.1) ENSMUST00000219429.1 NR_040616 uc029rjn.1 uc029rjn.2 uc029rjn.1 uc029rjn.2 
ENSMUST00000219437.2 Gm47946 ENSMUST00000219437.2 Gm47946 (from geneSymbol) ENSMUST00000219437.1 uc287rzu.1 uc287rzu.2 uc287rzu.1 uc287rzu.2 
ENSMUST00000219443.2 Arhgap5 ENSMUST00000219443.2 Rho GTPase activating protein 5, transcript variant 4 (from RefSeq NM_001408723.1) E9PYT0 E9Q0L8 ENSMUST00000219443.1 NM_001408723 P97393 RHG05_MOUSE Rhogap5 uc288ght.1 uc288ght.2 GTPase-activating protein for Rho family members. May interact with RASA1/p120GAP. Cytoplasm Cell membrane ; Peripheral membrane protein Note=Also membrane-associated in a fibrillar pattern that colocalizes with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin. Expressed in spinal cord, cerebellum, kidney, testis and lung. The pG1 pseudoGTPase domain does not bind GTP. positive regulation of mesenchymal cell proliferation GTPase activity GTPase activator activity GTP binding cytoplasm endoplasmic reticulum cytosol plasma membrane signal transduction regulation of cell size membrane positive regulation of cell migration SH2 domain binding positive regulation of GTPase activity uc288ght.1 uc288ght.2 
ENSMUST00000219445.2 Rassf9 ENSMUST00000219445.2 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 (from RefSeq NM_146240.4) ENSMUST00000219445.1 NM_146240 Pamci Pcip1 Q8BZV4 Q8K342 RASF9_MOUSE uc007gyf.1 uc007gyf.2 uc007gyf.3 May play a role in regulating vesicuar trafficking in cells. Interacts with PAM. Endosome. Note=Accumulates on perinuclear endosomes. endosome cytosol signal transduction trans-Golgi network transport vesicle membrane endosomal transport enzyme binding protein domain specific binding intracellular transport recycling endosome uc007gyf.1 uc007gyf.2 uc007gyf.3 
ENSMUST00000219448.2 Or2t29 ENSMUST00000219448.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt M9MMK5) ENSMUST00000219448.1 M9MMK5 M9MMK5_MOUSE Olfr224 Olfr329 Olfr329-ps Or2t29 uc057ayk.1 uc057ayk.2 uc057ayk.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc057ayk.1 uc057ayk.2 uc057ayk.3 
ENSMUST00000219454.2 Tle7 ENSMUST00000219454.2 Belongs to the WD repeat Groucho/TLE family. (from UniProt A0A1W2P7S4) A0A1W2P7S4 A0A1W2P7S4_MOUSE ENSMUST00000219454.1 Gm21964 Tle7 uc292ddy.1 uc292ddy.2 Belongs to the WD repeat Groucho/TLE family. transcription corepressor activity nucleus transcription factor complex regulation of transcription, DNA-templated repressing transcription factor binding negative regulation of canonical Wnt signaling pathway negative regulation of nucleic acid-templated transcription uc292ddy.1 uc292ddy.2 
ENSMUST00000219458.2 4930466K18Rik ENSMUST00000219458.2 4930466K18Rik (from geneSymbol) ENSMUST00000219458.1 LF197995 uc287rgg.1 uc287rgg.2 uc287rgg.1 uc287rgg.2 
ENSMUST00000219459.3 9230102K24Rik ENSMUST00000219459.3 RIKEN cDNA 9230102K24 gene (from RefSeq NR_028438.1) ENSMUST00000219459.1 ENSMUST00000219459.2 NR_028438 uc007gzm.1 uc007gzm.2 uc007gzm.3 uc007gzm.1 uc007gzm.2 uc007gzm.3 
ENSMUST00000219461.2 Gm48880 ENSMUST00000219461.2 Gm48880 (from geneSymbol) AK138033 ENSMUST00000219461.1 uc287uhh.1 uc287uhh.2 uc287uhh.1 uc287uhh.2 
ENSMUST00000219465.2 Gm47519 ENSMUST00000219465.2 Gm47519 (from geneSymbol) AK157326 ENSMUST00000219465.1 uc287uwu.1 uc287uwu.2 uc287uwu.1 uc287uwu.2 
ENSMUST00000219469.2 Gm47540 ENSMUST00000219469.2 Gm47540 (from geneSymbol) AK037511 ENSMUST00000219469.1 uc287vus.1 uc287vus.2 uc287vus.1 uc287vus.2 
ENSMUST00000219479.2 Tjp3 ENSMUST00000219479.2 tight junction protein 3, transcript variant 2 (from RefSeq NM_001282095.1) ENSMUST00000219479.1 NM_001282095 Q921G9 Q921G9_MOUSE Tjp3 uc007ghb.1 uc007ghb.2 uc007ghb.3 uc007ghb.4 Cell junction, tight junction Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Membrane ; Peripheral membrane protein ; Cytoplasmic side nucleus bicellular tight junction uc007ghb.1 uc007ghb.2 uc007ghb.3 uc007ghb.4 
ENSMUST00000219484.3 Gm34983 ENSMUST00000219484.3 Gm34983 (from geneSymbol) ENSMUST00000219484.1 ENSMUST00000219484.2 uc287ulu.1 uc287ulu.2 uc287ulu.3 uc287ulu.1 uc287ulu.2 uc287ulu.3 
ENSMUST00000219485.2 Gm6729 ENSMUST00000219485.2 Gm6729 (from geneSymbol) ENSMUST00000219485.1 uc287ttu.1 uc287ttu.2 uc287ttu.1 uc287ttu.2 
ENSMUST00000219486.3 Gm33979 ENSMUST00000219486.3 Gm33979 (from geneSymbol) ENSMUST00000219486.1 ENSMUST00000219486.2 uc287sag.1 uc287sag.2 uc287sag.3 uc287sag.1 uc287sag.2 uc287sag.3 
ENSMUST00000219490.2 ENSMUSG00000121697 ENSMUST00000219490.2 ENSMUSG00000121697 (from geneSymbol) ENSMUST00000219490.1 uc287ure.1 uc287ure.2 uc287ure.1 uc287ure.2 
ENSMUST00000219494.2 Gm47693 ENSMUST00000219494.2 Gm47693 (from geneSymbol) AK141171 ENSMUST00000219494.1 uc287qjt.1 uc287qjt.2 uc287qjt.1 uc287qjt.2 
ENSMUST00000219501.2 Gm33869 ENSMUST00000219501.2 Gm33869 (from geneSymbol) ENSMUST00000219501.1 uc288gff.1 uc288gff.2 uc288gff.1 uc288gff.2 
ENSMUST00000219511.2 Arhgap9 ENSMUST00000219511.2 Rho GTPase activating protein 9, transcript variant 1 (from RefSeq NM_001285785.2) Arhgap9 ENSMUST00000219511.1 NM_001285785 Q1HDU4 Q1HDU4_MOUSE uc007hja.1 uc007hja.2 uc007hja.3 uc007hja.4 GTPase activator activity phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm signal transduction regulation of GTPase activity positive regulation of GTPase activity uc007hja.1 uc007hja.2 uc007hja.3 uc007hja.4 
ENSMUST00000219513.2 9530018F02Rik ENSMUST00000219513.2 9530018F02Rik (from geneSymbol) AK083182 ENSMUST00000219513.1 uc288hiu.1 uc288hiu.2 uc288hiu.1 uc288hiu.2 
ENSMUST00000219521.2 Gm47031 ENSMUST00000219521.2 Gm47031 (from geneSymbol) ENSMUST00000219521.1 LF222339 uc287uor.1 uc287uor.2 uc287uor.1 uc287uor.2 
ENSMUST00000219528.3 Gm34921 ENSMUST00000219528.3 Gm34921 (from geneSymbol) ENSMUST00000219528.1 ENSMUST00000219528.2 uc287ull.1 uc287ull.2 uc287ull.3 uc287ull.1 uc287ull.2 uc287ull.3 
ENSMUST00000219535.2 Gm47093 ENSMUST00000219535.2 Gm47093 (from geneSymbol) AK090354 ENSMUST00000219535.1 uc287vvo.1 uc287vvo.2 uc287vvo.1 uc287vvo.2 
ENSMUST00000219546.2 Gm48204 ENSMUST00000219546.2 Gm48204 (from geneSymbol) ENSMUST00000219546.1 uc287urg.1 uc287urg.2 uc287urg.1 uc287urg.2 
ENSMUST00000219551.2 Garin2 ENSMUST00000219551.2 golgi associated RAB2 interactor 2, transcript variant 16 (from RefSeq NR_175789.1) ENSMUST00000219551.1 Fam71d GARI-L2 Garin2 NR_175789 Q80W24 Q80W24_MOUSE uc007nze.1 uc007nze.2 uc007nze.3 uc007nze.4 Belongs to the GARIN family. molecular_function biological_process uc007nze.1 uc007nze.2 uc007nze.3 uc007nze.4 
ENSMUST00000219552.2 Gm48495 ENSMUST00000219552.2 Gm48495 (from geneSymbol) AK080912 ENSMUST00000219552.1 uc287sts.1 uc287sts.2 uc287sts.1 uc287sts.2 
ENSMUST00000219561.2 Or5t5 ENSMUST00000219561.2 olfactory receptor family 5 subfamily T member 5, transcript variant 2 (from RefSeq NM_001368206.1) ENSMUST00000219561.1 NM_001368206 Olfr1093 Or5t5 Q8VF14 Q8VF14_MOUSE uc289xte.1 uc289xte.2 Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB174098.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity G-protein coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception of smell membrane integral component of membrane dendrite neurotransmitter receptor activity response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xte.1 uc289xte.2 
ENSMUST00000219564.2 ENSMUSG00000121753 ENSMUST00000219564.2 ENSMUSG00000121753 (from geneSymbol) BC082775 ENSMUST00000219564.1 uc029qyu.1 uc029qyu.2 uc029qyu.1 uc029qyu.2 
ENSMUST00000219565.2 Cdc5lrt4 ENSMUST00000219565.2 Belongs to the CEF1 family. (from UniProt A0A1W2P7S8) A0A1W2P7S8 A0A1W2P7S8_MOUSE Cdc5lrt1 Cdc5lrt4 ENSMUST00000219565.1 Gm32717 Gm32802 LF198247 uc029rha.1 uc029rha.2 uc029rha.3 Belongs to the CEF1 family. DNA binding uc029rha.1 uc029rha.2 uc029rha.3 
ENSMUST00000219578.3 Gm30906 ENSMUST00000219578.3 Gm30906 (from geneSymbol) ENSMUST00000219578.1 ENSMUST00000219578.2 uc287pkr.1 uc287pkr.2 uc287pkr.3 uc287pkr.1 uc287pkr.2 uc287pkr.3 
ENSMUST00000219594.3 Gm33337 ENSMUST00000219594.3 Gm33337 (from geneSymbol) ENSMUST00000219594.1 ENSMUST00000219594.2 uc287vcz.1 uc287vcz.2 uc287vcz.3 uc287vcz.1 uc287vcz.2 uc287vcz.3 
ENSMUST00000219595.3 5033421B08Rik ENSMUST00000219595.3 5033421B08Rik (from geneSymbol) AK050516 ENSMUST00000219595.1 ENSMUST00000219595.2 uc007mzr.1 uc007mzr.2 uc007mzr.3 uc007mzr.1 uc007mzr.2 uc007mzr.3 
ENSMUST00000219596.2 Gm1559 ENSMUST00000219596.2 predicted gene 1559 (from RefSeq NR_188936.1) ENSMUST00000219596.1 NR_188936 uc287tss.1 uc287tss.2 uc287tss.1 uc287tss.2 
ENSMUST00000219602.2 Or52e7 ENSMUST00000219602.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VGZ9) ENSMUST00000219602.1 Olfr676 Or52e7 Q8VGZ9 Q8VGZ9_MOUSE uc291twc.1 uc291twc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291twc.1 uc291twc.2 
ENSMUST00000219608.2 Gm48485 ENSMUST00000219608.2 predicted gene 5174, transcript variant 2 (from RefSeq NR_169112.1) ENSMUST00000219608.1 NR_169112 uc287tup.1 uc287tup.2 uc287tup.1 uc287tup.2 
ENSMUST00000219611.2 Gm10743 ENSMUST00000219611.2 Gm10743 (from geneSymbol) ENSMUST00000219611.1 uc287vfk.1 uc287vfk.2 uc287vfk.1 uc287vfk.2 
ENSMUST00000219615.2 Or5m13b ENSMUST00000219615.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TR90) ENSMUST00000219615.1 Olfr1026 Or5m13b Q7TR90 Q7TR90_MOUSE uc008kle.1 uc008kle.2 uc008kle.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc008kle.1 uc008kle.2 uc008kle.3 
ENSMUST00000219620.2 Gm47223 ENSMUST00000219620.2 Gm47223 (from geneSymbol) AK144104 ENSMUST00000219620.1 uc007gyl.1 uc007gyl.2 uc007gyl.3 uc007gyl.1 uc007gyl.2 uc007gyl.3 
ENSMUST00000219628.2 Gm48878 ENSMUST00000219628.2 Gm48878 (from geneSymbol) ENSMUST00000219628.1 uc287vib.1 uc287vib.2 uc287vib.1 uc287vib.2 
ENSMUST00000219636.3 Gm47948 ENSMUST00000219636.3 Gm47948 (from geneSymbol) ENSMUST00000219636.1 ENSMUST00000219636.2 uc288fvj.1 uc288fvj.2 uc288fvj.3 uc288fvj.1 uc288fvj.2 uc288fvj.3 
ENSMUST00000219640.2 Gm47200 ENSMUST00000219640.2 Gm47200 (from geneSymbol) ENSMUST00000219640.1 uc287vng.1 uc287vng.2 uc287vng.1 uc287vng.2 
ENSMUST00000219644.2 Gja10 ENSMUST00000219644.2 gap junction protein, alpha 10 (from RefSeq NM_001411853.1) A2ANV0 CXA10_MOUSE ENSMUST00000219644.1 NM_001411853 Q9WUS4 uc290lpn.1 uc290lpn.2 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning. A connexon is composed of a hexamer of connexins. Cell membrane ; Multi-pass membrane protein Cell junction, gap junction Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WUS4-1; Sequence=Displayed; Name=2; IsoId=Q9WUS4-2; Sequence=VSP_035809; Low levels were detected in skin, heart, kidney, testis, ovary, intestine. Expression not detected in brain, sciatic nerve or liver. According to PubMed:15147297 expression is detected only in horizontal cells in the inner nuclear layer of the retina and not in other neurons of the central nervous system or tissues. Detected in the outer plexiform layer of the retina (at protein level). Expressed in the retina from 16.5 dpc to P1, in the thymus from 18.5 dpc to P1, and in kidney from 16.5 dpc to 18.5 dpc. Mice are fertile and show no obvious anatomical or behavioral abnormalities. In horizontal cells of the retina tracer coupling is abolished but the spatial tuning of ganglion cells is unchanged. Belongs to the connexin family. Alpha-type (group II) subfamily. gap junction channel activity plasma membrane gap junction connexin complex cell communication gamete generation synapse assembly response to light stimulus membrane integral component of membrane cell junction detection of light stimulus involved in visual perception transmembrane transport uc290lpn.1 uc290lpn.2 
ENSMUST00000219647.2 Or55b3 ENSMUST00000219647.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PWI5) E9PWI5 E9PWI5_MOUSE ENSMUST00000219647.1 Olfr543 Or55b3 uc291tmp.1 uc291tmp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tmp.1 uc291tmp.2 
ENSMUST00000219656.2 Gm33336 ENSMUST00000219656.2 Gm33336 (from geneSymbol) ENSMUST00000219656.1 uc287uig.1 uc287uig.2 uc287uig.1 uc287uig.2 
ENSMUST00000219670.2 Gm29685 ENSMUST00000219670.2 predicted gene, 29685 (from RefSeq NR_131147.1) ENSMUST00000219670.1 NR_131147 uc056yid.1 uc056yid.2 uc056yid.3 uc056yid.1 uc056yid.2 uc056yid.3 
ENSMUST00000219677.2 Gm47910 ENSMUST00000219677.2 Gm47910 (from geneSymbol) ENSMUST00000219677.1 uc287qkv.1 uc287qkv.2 uc287qkv.1 uc287qkv.2 
ENSMUST00000219678.2 Gm46349 ENSMUST00000219678.2 Gm46349 (from geneSymbol) ENSMUST00000219678.1 uc288gde.1 uc288gde.2 uc288gde.1 uc288gde.2 
ENSMUST00000219684.2 Gm48773 ENSMUST00000219684.2 Gm48773 (from geneSymbol) ENSMUST00000219684.1 uc287pqj.1 uc287pqj.2 uc287pqj.1 uc287pqj.2 
ENSMUST00000219688.4 Gm34777 ENSMUST00000219688.4 Gm34777 (from geneSymbol) ENSMUST00000219688.1 ENSMUST00000219688.2 ENSMUST00000219688.3 KY467551 uc287ulh.1 uc287ulh.2 uc287ulh.3 uc287ulh.4 uc287ulh.1 uc287ulh.2 uc287ulh.3 uc287ulh.4 
ENSMUST00000219696.2 Gm49339 ENSMUST00000219696.2 Inhibitory receptor involved in the down-regulation of the immune response (PubMed:10026201, PubMed:24935931). Receptor for FN1 (PubMed:34089617). Receptor for integrin ITGAV/ITGB3 (PubMed:11323698). Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3 (PubMed:8855262, PubMed:10026201, PubMed:11457897, PubMed:11323698). Also inhibits KITLG/SCF-mediated mast cell activation (PubMed:12884301). Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells (PubMed:24935931). Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells (PubMed:12682239). Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation (PubMed:18792399). Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury (PubMed:14557414). Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation (PubMed:17761953). Inhibits lysis by natural killer cells (PubMed:8977169). (from UniProt Q64281) AK170368 ENSMUST00000219696.1 Gp49b LRB4A_MOUSE Lilrb4a Q64281 Q64312 uc287rck.1 uc287rck.2 Inhibitory receptor involved in the down-regulation of the immune response (PubMed:10026201, PubMed:24935931). Receptor for FN1 (PubMed:34089617). Receptor for integrin ITGAV/ITGB3 (PubMed:11323698). Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3 (PubMed:8855262, PubMed:10026201, PubMed:11457897, PubMed:11323698). Also inhibits KITLG/SCF-mediated mast cell activation (PubMed:12884301). Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells (PubMed:24935931). Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells (PubMed:12682239). Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation (PubMed:18792399). Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury (PubMed:14557414). Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation (PubMed:17761953). Inhibits lysis by natural killer cells (PubMed:8977169). Interacts (when tyrosine phosphorylated) with SH2 domain- containing phosphatases PTPN6/SHP-1 and PTPN11/SHP-2; interaction with PTPN6 enhances inhibition of mast cell activation. Cell membrane ingle-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=GP49B1 ; IsoId=Q64281-1; Sequence=Displayed; Name=2; Synonyms=GP49B2 ; IsoId=Q64281-2; Sequence=VSP_002510, VSP_002511; Expressed on mast cells and natural killer cells (at protein level) (PubMed:8977169, PubMed:8977170, PubMed:11457897). Expressed on neutrophils (at protein level) (PubMed:14557414). Expressed on eosinophils (at protein level) (PubMed:17761953). Expressed on dendritic cells (at protein level) (PubMed:18792399). Expressed on memory and marginal zone B cells (at protein level) (PubMed:24935931). Expressed on CD8 T cells (at protein level) (PubMed:12682239). Expressed in the uterus of pregnant mice where it is detected at day 4.0 of pregnancy with levels dropping at day 4.5 (PubMed:9338594). Highly expressed in the luminal epithelium of uterine endometrium with lower levels in the glandular epithelium (PubMed:9338594). Induced by lipopolysaccharide on neutrophils (at protein level) (PubMed:14557414). Induced by IL6 and LIF (PubMed:9338594). Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Tyrosine phosphorylated. No effect on fertility or litter size (PubMed:10982834, PubMed:11457897). Normal development of mast cells and natural killer cells (PubMed:10982834). Increased severity of local and systemic anaphylactic reactions (PubMed:11457897). Significantly increased sensitivity to IgE-dependent passive cutaneous anaphylaxis with greater tissue swelling and mast cell degranulation, and significantly greater and faster death rate in active systemic anaphylaxis (PubMed:11457897). However, another study found no effect on mast cell activity with no increase in mast cell degranulation (PubMed:10982834). Macroscopic hemorrhages following intradermal injection of E.coli lipopolysaccharide with increased neutrophil numbers around the site of injection (PubMed:14557414). Normal B cell development and memory B cell formation but increased production by marginal zone and memory B cells of IgM after a primary immunization and of IgM, IgG1 and IgE after a secondary immunization (PubMed:24935931). Reduced ERK activation and reduced Prdm1/Blimp1 expression, indicative of suppression of plasma cell differentiation (PubMed:24935931). No effect on antigen uptake or cytokine production by dendritic cells but dendritic cells show enhanced antigen presentation to T cells and induce increased T cell stimulation (PubMed:18792399). Increased neutrophilia, eosinophilia and mast cell degranulation following ocular ragweed (RW) sensitization and challenge, and increased lung inflammation following RW sensitization and challenge (PubMed:17761953). Increased Kitlg/SCF-induced mast cell degranulation and tissue swelling (PubMed:12884301). Enhanced IFNG production by CD8 T cells, CD4 T cells and NK cells following viral infection (PubMed:12682239). neutrophil homeostasis adaptive immune response immune system process inflammatory response to antigenic stimulus plasma membrane inflammatory response blood coagulation response to wounding response to nematode external side of plasma membrane response to extracellular stimulus membrane integral component of membrane response to lipopolysaccharide CD4-positive, alpha-beta T cell proliferation CD8-positive, alpha-beta T cell proliferation type 2 immune response cytokine metabolic process chemokine metabolic process response to other organism cellular response to lipopolysaccharide uc287rck.1 uc287rck.2 
ENSMUST00000219700.2 4930551I15Rik ENSMUST00000219700.2 4930551I15Rik (from geneSymbol) ENSMUST00000219700.1 uc287sbj.1 uc287sbj.2 uc287sbj.1 uc287sbj.2 
ENSMUST00000219716.2 Gm47341 ENSMUST00000219716.2 Gm47341 (from geneSymbol) ENSMUST00000219716.1 uc287vdv.1 uc287vdv.2 uc287vdv.1 uc287vdv.2 
ENSMUST00000219725.2 Gm47821 ENSMUST00000219725.2 Gm47821 (from geneSymbol) ENSMUST00000219725.1 uc288exw.1 uc288exw.2 uc288exw.1 uc288exw.2 
ENSMUST00000219731.2 Gm47739 ENSMUST00000219731.2 Gm47739 (from geneSymbol) ENSMUST00000219731.1 uc287rfx.1 uc287rfx.2 uc287rfx.1 uc287rfx.2 
ENSMUST00000219740.3 Gm47752 ENSMUST00000219740.3 Gm47752 (from geneSymbol) ENSMUST00000219740.1 ENSMUST00000219740.2 uc288hlt.1 uc288hlt.2 uc288hlt.3 uc288hlt.1 uc288hlt.2 uc288hlt.3 
ENSMUST00000219743.2 Gm47574 ENSMUST00000219743.2 Gm47574 (from geneSymbol) ENSMUST00000219743.1 uc287rwe.1 uc287rwe.2 uc287rwe.1 uc287rwe.2 
ENSMUST00000219760.2 Cdc5lrt7 ENSMUST00000219760.2 Belongs to the CEF1 family. (from UniProt A0A1W2P7Z8) A0A1W2P7Z8 A0A1W2P7Z8_MOUSE Cdc5lrt10 Cdc5lrt7 ENSMUST00000219760.1 Gm9045 Gm9049 LF224720 uc029rik.1 uc029rik.2 uc029rik.3 Belongs to the CEF1 family. DNA binding uc029rik.1 uc029rik.2 uc029rik.3 
ENSMUST00000219775.2 Gm49751 ENSMUST00000219775.2 Gm49751 (from geneSymbol) ENSMUST00000219775.1 uc287vcy.1 uc287vcy.2 uc287vcy.1 uc287vcy.2 
ENSMUST00000219777.2 Gm47700 ENSMUST00000219777.2 Gm47700 (from geneSymbol) AK135469 ENSMUST00000219777.1 uc287qkc.1 uc287qkc.2 uc287qkc.1 uc287qkc.2 
ENSMUST00000219794.2 Gm47419 ENSMUST00000219794.2 Gm47419 (from geneSymbol) ENSMUST00000219794.1 uc287uwl.1 uc287uwl.2 uc287uwl.1 uc287uwl.2 
ENSMUST00000219803.2 Or13n4 ENSMUST00000219803.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q920Z2) ENSMUST00000219803.1 Olfr702 Or13n4 Q920Z2 Q920Z2_MOUSE uc033jbo.1 uc033jbo.2 uc033jbo.3 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc033jbo.1 uc033jbo.2 uc033jbo.3 
ENSMUST00000219810.2 Gm48014 ENSMUST00000219810.2 Gm48014 (from geneSymbol) ENSMUST00000219810.1 uc288ikx.1 uc288ikx.2 uc288ikx.1 uc288ikx.2 
ENSMUST00000219817.2 Tmprss9 ENSMUST00000219817.2 Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed. (from UniProt D3YTR8) BC158102 D3YTR8 D3YTR8_MOUSE ENSMUST00000219817.1 Tmprss9 uc287teh.1 uc287teh.2 Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed. Cell membrane Membrane ; Single-pass type II membrane protein Belongs to the peptidase S1 family. Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase activity integral component of plasma membrane proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc287teh.1 uc287teh.2 
ENSMUST00000219831.2 Gm10777 ENSMUST00000219831.2 Gm10777 (from geneSymbol) ENSMUST00000219831.1 uc287tnb.1 uc287tnb.2 uc287tnb.1 uc287tnb.2 
ENSMUST00000219839.2 Chchd10 ENSMUST00000219839.2 coiled-coil-helix-coiled-coil-helix domain containing 10 (from RefSeq NM_175329.4) Chchd10 ENSMUST00000219839.1 NM_175329 Ndg2 Q7TNL9 Q7TNL9_MOUSE uc007ftq.1 uc007ftq.2 uc007ftq.3 protein binding nucleus mitochondrion mitochondrial intermembrane space oxidative phosphorylation mitochondrion organization stabilization of membrane potential mitochondria-nucleus signaling pathway macromolecular complex disassembly protein localization to nucleus MICOS complex mitochondrial nucleoid organization positive regulation of release of cytochrome c from mitochondria maintenance of synapse structure positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway positive regulation of transcription from mitochondrial promoter positive regulation of cristae formation positive regulation of cytochrome-c oxidase activity uc007ftq.1 uc007ftq.2 uc007ftq.3 
ENSMUST00000219852.4 Gm36172 ENSMUST00000219852.4 Gm36172 (from geneSymbol) ENSMUST00000219852.1 ENSMUST00000219852.2 ENSMUST00000219852.3 uc287qcq.1 uc287qcq.2 uc287qcq.3 uc287qcq.4 uc287qcq.1 uc287qcq.2 uc287qcq.3 uc287qcq.4 
ENSMUST00000219871.2 Or4c31 ENSMUST00000219871.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VFF8) ENSMUST00000219871.1 Olfr1183 Olfr1206 Or4c31 Q8VFF8 Q8VFF8_MOUSE uc289xyk.1 uc289xyk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289xyk.1 uc289xyk.2 
ENSMUST00000219875.2 Gm47017 ENSMUST00000219875.2 Gm47017 (from geneSymbol) AK082263 ENSMUST00000219875.1 uc287raw.1 uc287raw.2 uc287raw.1 uc287raw.2 
ENSMUST00000219876.2 Gm47338 ENSMUST00000219876.2 Gm47338 (from geneSymbol) ENSMUST00000219876.1 uc287utv.1 uc287utv.2 uc287utv.1 uc287utv.2 
ENSMUST00000219877.2 Faxdc2 ENSMUST00000219877.2 fatty acid hydroxylase domain containing 2 (from RefSeq NM_001378239.1) A0A1W2P8B8 A0A1W2P8B8_MOUSE ENSMUST00000219877.1 Faxdc2 NM_001378239 uc287yin.1 uc287yin.2 Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; C-4 methylsterol oxidase activity iron ion binding endoplasmic reticulum membrane lipid biosynthetic process membrane integral component of membrane sterol biosynthetic process oxidoreductase activity oxidation-reduction process uc287yin.1 uc287yin.2 
ENSMUST00000219888.2 Gm6150 ENSMUST00000219888.2 predicted gene 6150 (from RefSeq NR_038036.1) ENSMUST00000219888.1 NR_038036 uc007eix.1 uc007eix.2 uc007eix.3 uc007eix.4 uc007eix.1 uc007eix.2 uc007eix.3 uc007eix.4 
ENSMUST00000219909.2 Gm47689 ENSMUST00000219909.2 Gm47689 (from geneSymbol) ENSMUST00000219909.1 uc288hft.1 uc288hft.2 uc288hft.1 uc288hft.2 
ENSMUST00000219913.2 Gm48868 ENSMUST00000219913.2 Gm48868 (from geneSymbol) ENSMUST00000219913.1 uc287uhc.1 uc287uhc.2 uc287uhc.1 uc287uhc.2 
ENSMUST00000219915.2 Hbs1l ENSMUST00000219915.2 Hbs1-like (S. cerevisiae), transcript variant 1 (from RefSeq NM_019702.2) ENSMUST00000219915.1 HBS1L_MOUSE Hbs1 Hbs1l Kiaa1038 NM_019702 Q69ZS7 Q91Z32 Q9CVT2 Q9CZ95 Q9WTY5 uc007eoo.1 uc007eoo.2 uc007eoo.3 GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Component of the Pelota-HBS1L complex, also named Dom34-Hbs1 complex, composed of PELO and HBS1L. Interacts with the SKI complex. Q69ZS7; Q80X73: Pelo; NbExp=2; IntAct=EBI-16114976, EBI-16114899; Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q69ZS7-1; Sequence=Displayed; Name=2; IsoId=Q69ZS7-2; Sequence=VSP_013626; Name=3; IsoId=Q69ZS7-3; Sequence=VSP_013627, VSP_013628; Detected in embryos. Embryonic lethality; embryos fail to develop after 8.5 dpc (PubMed:33899734). Conditional deletion in the in the developing cerebellum and midbrain leads to severe development defects in the cerebellum characterized by the absence of multiple cell types (PubMed:33899734). In contrast, conditional deletion in the adult cerebellum and midbrain does not cause defects in neuron survival (PubMed:33899734). Defects are probably caused by ribosome pausing, due to inability to rescue stalled ribosomes (PubMed:33899734). Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. Sequence=BAD32369.1; Type=Erroneous initiation; Evidence=; nucleotide binding translation elongation factor activity GTPase activity protein binding GTP binding translation translational elongation uc007eoo.1 uc007eoo.2 uc007eoo.3 
ENSMUST00000219931.2 Trdn ENSMUST00000219931.2 Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength (PubMed:19843516). Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (from UniProt E9Q9K5) AF223417 E9Q9K5 ENSMUST00000219931.1 Q8VIN7 Q8VIN8 Q8VIN9 Q9CV36 TRDN_MOUSE Trdn uc007eub.1 uc007eub.2 uc007eub.3 uc007eub.4 Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength (PubMed:19843516). Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. Homooligomer of variable subunit number; disulfide-linked. Interacts with CASQ1 and RYR1 in skeletal muscle. Interacts with CASQ2. Sarcoplasmic reticulum membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=E9Q9K5-1; Sequence=Displayed; Name=2; Synonyms=Cardiac triadin 1; IsoId=E9Q9K5-2; Sequence=VSP_056796, VSP_056797; Name=3; Synonyms=Cardiac triadin 2; IsoId=E9Q9K5-3; Sequence=VSP_056798, VSP_056799; Name=4; Synonyms=Cardiac triadin 3, Trisk 32; IsoId=E9Q9K5-4; Sequence=VSP_056795, VSP_056800, VSP_056801; Detected in heart (at protein level). Detected in heart. Phosphorylated by CaMK2. N-glycosylated. Mice appear normal; they are viable and fertile but have reduced muscular strength, due to defects in the structure of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. In mutant mice, about 25% of the triads are in oblique or longitudinal orientation, instead of the normal transversal orientation (PubMed:19843516). Similar structural defects are seen in the heart, leading to impaired excitation- contraction coupling. Mutant mice are subject to stress-induced ventricular tachycardia (PubMed:19383796). receptor binding protein binding endoplasmic reticulum cytosol plasma membrane cellular calcium ion homeostasis response to bacterium regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum junctional sarcoplasmic reticulum membrane release of sequestered calcium ion into cytosol by sarcoplasmic reticulum membrane integral component of membrane sarcoplasmic reticulum junctional membrane complex cytoplasmic microtubule organization sarcoplasmic reticulum membrane calcium channel complex intracellular membrane-bounded organelle ion channel binding negative regulation of release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol heart contraction positive regulation of ryanodine-sensitive calcium-release channel activity regulation of cardiac muscle cell membrane potential endoplasmic reticulum membrane organization uc007eub.1 uc007eub.2 uc007eub.3 uc007eub.4 
ENSMUST00000219933.2 Gm47625 ENSMUST00000219933.2 Gm47625 (from geneSymbol) AK149647 ENSMUST00000219933.1 uc287uyw.1 uc287uyw.2 uc287uyw.1 uc287uyw.2 
ENSMUST00000219938.2 Gm47592 ENSMUST00000219938.2 Gm47592 (from geneSymbol) AK081216 ENSMUST00000219938.1 uc287uam.1 uc287uam.2 uc287uam.1 uc287uam.2 
ENSMUST00000219940.2 Gm47477 ENSMUST00000219940.2 Gm47477 (from geneSymbol) ENSMUST00000219940.1 uc287utg.1 uc287utg.2 uc287utg.1 uc287utg.2 
ENSMUST00000219957.2 Gm47720 ENSMUST00000219957.2 Gm47720 (from geneSymbol) AK162284 ENSMUST00000219957.1 uc288gmn.1 uc288gmn.2 uc288gmn.1 uc288gmn.2 
ENSMUST00000219965.2 Gm47691 ENSMUST00000219965.2 Gm47691 (from geneSymbol) ENSMUST00000219965.1 uc287ppa.1 uc287ppa.2 uc287ppa.1 uc287ppa.2 
ENSMUST00000219966.2 Gm47769 ENSMUST00000219966.2 Gm47769 (from geneSymbol) ENSMUST00000219966.1 uc287ptf.1 uc287ptf.2 uc287ptf.1 uc287ptf.2 
ENSMUST00000219969.2 Krtap10-30 ENSMUST00000219969.2 predicted gene 9736 (from RefSeq NM_001370808.1) A0A1W2P7N1 A0A1W2P7N1_MOUSE ENSMUST00000219969.1 Gm9736 NM_001370808 uc287smk.1 uc287smk.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc287smk.1 uc287smk.2 
ENSMUST00000219979.2 Gm867 ENSMUST00000219979.2 predicted gene 867, transcript variant 1 (from RefSeq NM_001277132.1) A0A1W2P7T4 A0A1W2P7T4_MOUSE ENSMUST00000219979.1 Gm867 NM_001277132 uc033fqi.1 uc033fqi.2 uc033fqi.3 molecular_function cellular_component biological_process uc033fqi.1 uc033fqi.2 uc033fqi.3 
ENSMUST00000219993.2 Galnt16 ENSMUST00000219993.2 polypeptide N-acetylgalactosaminyltransferase 16, transcript variant 2 (from RefSeq NM_001361700.1) ENSMUST00000219993.1 GLT16_MOUSE Galntl1 NM_001361700 Q60GT0 Q9JJ61 uc007oaw.1 uc007oaw.2 uc007oaw.3 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3- O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Golgi apparatus membrane ; Single- pass type II membrane protein In the CNS, it is predominantly expressed in several distinct hypothalamic, thalamic and amygdaloid nuclei. The most abundant level of expression is in the paraventricular, ventromedial and arcuate nuclei of the hypothalamus, the anterodorsal and parafascicular nuclei of the thalamus and the central, basomedial and medial nuclei of the amygdala. Also expressed in cerebral cortex, lateral septum, habenula and hippocampus. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Was originally termed Galnt10/pp-GaNTase 10. Name=Functional Glycomics Gateway - GTase; Note=Putative polypeptide N-acetylgalactosaminyltransferase-like protein 1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_524"; Golgi membrane polypeptide N-acetylgalactosaminyltransferase activity Golgi apparatus protein glycosylation membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via serine protein O-linked glycosylation via threonine carbohydrate binding metal ion binding uc007oaw.1 uc007oaw.2 uc007oaw.3 
ENSMUST00000220001.2 Or2at1 ENSMUST00000220001.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q519) E9Q519 E9Q519_MOUSE ENSMUST00000220001.1 Olfr521 Or2at1 uc291tak.1 uc291tak.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291tak.1 uc291tak.2 
ENSMUST00000220004.2 ENSMUSG00000121641 ENSMUST00000220004.2 ENSMUSG00000121641 (from geneSymbol) ENSMUST00000220004.1 uc288gnx.1 uc288gnx.2 uc288gnx.1 uc288gnx.2 
ENSMUST00000220008.2 Or6d13 ENSMUST00000220008.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TS32) ENSMUST00000220008.1 Olfr213 Or6d13 Q7TS32 Q7TS32_MOUSE uc291idl.1 uc291idl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291idl.1 uc291idl.2 
ENSMUST00000220015.3 Gm48722 ENSMUST00000220015.3 Gm48722 (from geneSymbol) ENSMUST00000220015.1 ENSMUST00000220015.2 uc287pog.1 uc287pog.2 uc287pog.3 uc287pog.1 uc287pog.2 uc287pog.3 
ENSMUST00000220016.3 Gm47524 ENSMUST00000220016.3 Gm47524 (from geneSymbol) ENSMUST00000220016.1 ENSMUST00000220016.2 uc287uww.1 uc287uww.2 uc287uww.3 uc287uww.1 uc287uww.2 uc287uww.3 
ENSMUST00000220021.2 Gm47862 ENSMUST00000220021.2 Gm47862 (from geneSymbol) AK046692 ENSMUST00000220021.1 uc287vjs.1 uc287vjs.2 uc287vjs.1 uc287vjs.2 
ENSMUST00000220023.2 Gm48591 ENSMUST00000220023.2 Gm48591 (from geneSymbol) ENSMUST00000220023.1 uc287vgr.1 uc287vgr.2 uc287vgr.1 uc287vgr.2 
ENSMUST00000220029.2 Gm32172 ENSMUST00000220029.2 predicted gene, 32172 (from RefSeq NR_152745.1) ENSMUST00000220029.1 NR_152745 uc007elf.1 uc007elf.2 uc007elf.1 uc007elf.2 
ENSMUST00000220031.2 9230116L04Rik ENSMUST00000220031.2 RIKEN cDNA 9230116L04 gene (from RefSeq NR_110486.1) ENSMUST00000220031.1 NR_110486 uc007nzu.1 uc007nzu.2 uc007nzu.3 uc007nzu.1 uc007nzu.2 uc007nzu.3 
ENSMUST00000220041.2 Stx7 ENSMUST00000220041.2 syntaxin 7, transcript variant 2 (from RefSeq NM_001358563.1) ENSMUST00000220041.1 NM_001358563 Q8BH40 Q8BH40_MOUSE Stx-7 Stx7 uc007eqt.1 uc007eqt.2 uc007eqt.3 May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. Early endosome membrane ; Single-pass type IV membrane protein Endosome membrane ; Single-pass type IV membrane protein Membrane ; Single-pass type IV membrane protein Belongs to the syntaxin family. SNARE binding immunological synapse positive regulation of T cell mediated cytotoxicity SNAP receptor activity lysosome endosome early endosome late endosome plasma membrane intracellular protein transport membrane integral component of membrane vesicle-mediated transport chloride channel inhibitor activity syntaxin binding endocytic vesicle vesicle azurophil granule perinuclear region of cytoplasm organelle localization recycling endosome membrane fusion tertiary granule organelle assembly positive regulation of receptor localization to synapse regulation of protein localization to plasma membrane uc007eqt.1 uc007eqt.2 uc007eqt.3 
ENSMUST00000220049.2 Baz2a ENSMUST00000220049.2 Belongs to the WAL family. (from UniProt F8VPM0) BC148495 Baz2a ENSMUST00000220049.1 F8VPM0 F8VPM0_MOUSE uc287vqr.1 uc287vqr.2 Belongs to the WAL family. RNA polymerase I CORE element sequence-specific DNA binding RNA polymerase I transcriptional preinitiation complex assembly DNA binding nucleus cytosol nuclear speck histone binding metal ion binding uc287vqr.1 uc287vqr.2 
ENSMUST00000220050.2 Gm47624 ENSMUST00000220050.2 Gm47624 (from geneSymbol) ENSMUST00000220050.1 uc287rey.1 uc287rey.2 uc287rey.1 uc287rey.2 
ENSMUST00000220053.2 Gm32365 ENSMUST00000220053.2 Gm32365 (from geneSymbol) ENSMUST00000220053.1 uc287vbm.1 uc287vbm.2 uc287vbm.1 uc287vbm.2 
ENSMUST00000220056.2 Gm49344 ENSMUST00000220056.2 Gm49344 (from geneSymbol) ENSMUST00000220056.1 uc287uzx.1 uc287uzx.2 uc287uzx.1 uc287uzx.2 
ENSMUST00000220057.2 Gm47627 ENSMUST00000220057.2 Gm47627 (from geneSymbol) ENSMUST00000220057.1 uc287umj.1 uc287umj.2 uc287umj.1 uc287umj.2 
ENSMUST00000220062.2 Gm49918 ENSMUST00000220062.2 predicted gene 2696 (from RefSeq NM_001205009.2) A0A1W2P709 A0A1W2P709_MOUSE ENSMUST00000220062.1 Gm2696 Gm49918 NM_001205009 uc029qzr.1 uc029qzr.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc029qzr.1 uc029qzr.2 
ENSMUST00000220073.2 Gdf7 ENSMUST00000220073.2 growth differentiation factor 7, transcript variant 2 (from RefSeq NM_013527.1) ENSMUST00000220073.1 GDF7_MOUSE Gdf-7 NM_013527 P43029 Q7TNX4 Q99MY1 uc007mzl.1 uc007mzl.2 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. Mice lacking a functional copy of this gene exhibit absence of some spinal dopaminergic neurons and brain defects, male sterility, and premature death. [provided by RefSeq, Sep 2016]. Homodimer; disulfide-linked. Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P43029-1; Sequence=Displayed; Name=2; IsoId=P43029-2; Sequence=VSP_010764; Belongs to the TGF-beta family. cytokine activity transforming growth factor beta receptor binding protein binding extracellular region extracellular space axon guidance growth factor activity positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation roof plate formation spinal cord association neuron differentiation neural tube development gland morphogenesis BMP signaling pathway epithelial cell differentiation midbrain development activin receptor signaling pathway protein homodimerization activity regulation of apoptotic process regulation of MAPK cascade cell fate commitment positive regulation of neuron differentiation positive regulation of transcription, DNA-templated cell development reproductive structure development branching morphogenesis of an epithelial tube forebrain morphogenesis pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction morphogenesis of an epithelial fold positive regulation of tendon cell differentiation uc007mzl.1 uc007mzl.2 
ENSMUST00000220077.2 A430103D13Rik ENSMUST00000220077.2 A430103D13Rik (from geneSymbol) AK020759 ENSMUST00000220077.1 uc288hgx.1 uc288hgx.2 uc288hgx.1 uc288hgx.2 
ENSMUST00000220083.3 Gm4129 ENSMUST00000220083.3 predicted gene 4129 (from RefSeq NR_188960.1) ENSMUST00000220083.1 ENSMUST00000220083.2 NR_188960 uc287vjc.1 uc287vjc.2 uc287vjc.3 uc287vjc.1 uc287vjc.2 uc287vjc.3 
ENSMUST00000220084.2 Krtap10-28 ENSMUST00000220084.2 predicted gene 9508 (from RefSeq NM_001370817.1) A0A1W2P7W0 A0A1W2P7W0_MOUSE ENSMUST00000220084.1 Gm9508 NM_001370817 uc287smf.1 uc287smf.2 molecular_function cellular_component intermediate filament biological_process keratin filament uc287smf.1 uc287smf.2 
ENSMUST00000220085.2 Glipr1l3 ENSMUST00000220085.2 GLI pathogenesis-related 1 like 3, transcript variant 2 (from RefSeq NR_164318.1) A0A1W2P7V2 A0A1W2P7V2_MOUSE ENSMUST00000220085.1 Glipr1l3 NR_164318 uc287uwj.1 uc287uwj.2 Belongs to the CRISP family. molecular_function extracellular region extracellular space biological_process uc287uwj.1 uc287uwj.2 
ENSMUST00000220086.2 Gm48377 ENSMUST00000220086.2 Gm48377 (from geneSymbol) ENSMUST00000220086.1 LF198223 uc287urw.1 uc287urw.2 uc287urw.1 uc287urw.2 
ENSMUST00000220089.2 Gm47908 ENSMUST00000220089.2 Gm47908 (from geneSymbol) AJ250694 ENSMUST00000220089.1 uc287qkt.1 uc287qkt.2 uc287qkt.1 uc287qkt.2 
ENSMUST00000220113.2 Or5b118 ENSMUST00000220113.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TQQ8) ENSMUST00000220113.1 Olfr1474 Or5b118 Q7TQQ8 Q7TQQ8_MOUSE uc289rfe.1 uc289rfe.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289rfe.1 uc289rfe.2 
ENSMUST00000220118.2 Gm47073 ENSMUST00000220118.2 Gm47073 (from geneSymbol) AK153802 ENSMUST00000220118.1 uc287tpd.1 uc287tpd.2 uc287tpd.1 uc287tpd.2 
ENSMUST00000220128.2 Gas2l3 ENSMUST00000220128.2 growth arrest-specific 2 like 3, transcript variant 3 (from RefSeq NM_001284344.1) ENSMUST00000220128.1 Gas2l3 NM_001284344 Q3TPC3 Q3TPC3_MOUSE uc033fru.1 uc033fru.2 uc033fru.3 Belongs to the GAS2 family. microtubule cytoskeleton organization actin binding cytoskeleton microtubule binding actin cytoskeleton organization uc033fru.1 uc033fru.2 uc033fru.3 
ENSMUST00000220132.3 1700104L18Rik ENSMUST00000220132.3 RIKEN cDNA 1700104L18 gene (from RefSeq NR_108033.1) ENSMUST00000220132.1 ENSMUST00000220132.2 NR_108033 uc033gdo.1 uc033gdo.2 uc033gdo.3 uc033gdo.1 uc033gdo.2 uc033gdo.3 
ENSMUST00000220135.2 Gm47919 ENSMUST00000220135.2 Gm47919 (from geneSymbol) ENSMUST00000220135.1 uc287roh.1 uc287roh.2 uc287roh.1 uc287roh.2 
ENSMUST00000220137.2 Gm48809 ENSMUST00000220137.2 Gm48809 (from geneSymbol) AK033546 ENSMUST00000220137.1 uc288fue.1 uc288fue.2 uc288fue.1 uc288fue.2 
ENSMUST00000220141.2 Gm48619 ENSMUST00000220141.2 Gm48619 (from geneSymbol) AK144725 ENSMUST00000220141.1 uc288etf.1 uc288etf.2 uc288etf.1 uc288etf.2 
ENSMUST00000220145.2 Gm47607 ENSMUST00000220145.2 Gm47607 (from geneSymbol) ENSMUST00000220145.1 uc287req.1 uc287req.2 uc287req.1 uc287req.2 
ENSMUST00000220149.2 Gm48874 ENSMUST00000220149.2 Gm48874 (from geneSymbol) AB349905 ENSMUST00000220149.1 uc287uhe.1 uc287uhe.2 uc287uhe.1 uc287uhe.2 
ENSMUST00000220151.3 Gm47480 ENSMUST00000220151.3 Gm47480 (from geneSymbol) ENSMUST00000220151.1 ENSMUST00000220151.2 uc287vdl.1 uc287vdl.2 uc287vdl.3 uc287vdl.1 uc287vdl.2 uc287vdl.3 
ENSMUST00000220153.2 ENSMUSG00000121432 ENSMUST00000220153.2 ENSMUSG00000121432 (from geneSymbol) ENSMUST00000220153.1 uc289zet.1 uc289zet.2 uc289zet.1 uc289zet.2 
ENSMUST00000220154.2 Gm47879 ENSMUST00000220154.2 Gm47879 (from geneSymbol) ENSMUST00000220154.1 uc288hnc.1 uc288hnc.2 uc288hnc.1 uc288hnc.2 
ENSMUST00000220158.3 4930452L12Rik ENSMUST00000220158.3 4930452L12Rik (from geneSymbol) AK015449 ENSMUST00000220158.1 ENSMUST00000220158.2 uc287rhs.1 uc287rhs.2 uc287rhs.3 uc287rhs.1 uc287rhs.2 uc287rhs.3 
ENSMUST00000220160.2 Gm47801 ENSMUST00000220160.2 Gm47801 (from geneSymbol) ENSMUST00000220160.1 uc287vjg.1 uc287vjg.2 uc287vjg.1 uc287vjg.2 
ENSMUST00000220165.2 Taf7l2 ENSMUST00000220165.2 Taf7l2 (from geneSymbol) BC147630 ENSMUST00000220165.1 uc287uyr.1 uc287uyr.2 uc287uyr.1 uc287uyr.2 
ENSMUST00000220168.2 Gm32023 ENSMUST00000220168.2 Gm32023 (from geneSymbol) ENSMUST00000220168.1 uc287rvr.1 uc287rvr.2 uc287rvr.1 uc287rvr.2 
ENSMUST00000220176.2 Or8g35 ENSMUST00000220176.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EQ97) ENSMUST00000220176.1 Olfr955 Or8g35 Q9EQ97 Q9EQ97_MOUSE uc292gbc.1 uc292gbc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292gbc.1 uc292gbc.2 
ENSMUST00000220177.3 Gm47645 ENSMUST00000220177.3 Gm47645 (from geneSymbol) ENSMUST00000220177.1 ENSMUST00000220177.2 uc288gnv.1 uc288gnv.2 uc288gnv.3 uc288gnv.1 uc288gnv.2 uc288gnv.3 
ENSMUST00000220181.2 Gm48001 ENSMUST00000220181.2 Gm48001 (from geneSymbol) ENSMUST00000220181.1 uc288epq.1 uc288epq.2 uc288epq.1 uc288epq.2 
ENSMUST00000220182.2 Lilrb4a ENSMUST00000220182.2 Inhibitory receptor involved in the down-regulation of the immune response (PubMed:10026201, PubMed:24935931). Receptor for FN1 (PubMed:34089617). Receptor for integrin ITGAV/ITGB3 (PubMed:11323698). Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3 (PubMed:8855262, PubMed:10026201, PubMed:11457897, PubMed:11323698). Also inhibits KITLG/SCF-mediated mast cell activation (PubMed:12884301). Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells (PubMed:24935931). Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells (PubMed:12682239). Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation (PubMed:18792399). Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury (PubMed:14557414). Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation (PubMed:17761953). Inhibits lysis by natural killer cells (PubMed:8977169). (from UniProt Q64281) ENSMUST00000220182.1 Gp49b LRB4A_MOUSE Lilrb4a Q64281 Q64312 U05266 uc011xdq.1 uc011xdq.2 uc011xdq.3 uc011xdq.4 uc011xdq.5 Inhibitory receptor involved in the down-regulation of the immune response (PubMed:10026201, PubMed:24935931). Receptor for FN1 (PubMed:34089617). Receptor for integrin ITGAV/ITGB3 (PubMed:11323698). Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3 (PubMed:8855262, PubMed:10026201, PubMed:11457897, PubMed:11323698). Also inhibits KITLG/SCF-mediated mast cell activation (PubMed:12884301). Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells (PubMed:24935931). Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells (PubMed:12682239). Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation (PubMed:18792399). Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury (PubMed:14557414). Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation (PubMed:17761953). Inhibits lysis by natural killer cells (PubMed:8977169). Interacts (when tyrosine phosphorylated) with SH2 domain- containing phosphatases PTPN6/SHP-1 and PTPN11/SHP-2; interaction with PTPN6 enhances inhibition of mast cell activation. Cell membrane ingle-pass type I membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=GP49B1 ; IsoId=Q64281-1; Sequence=Displayed; Name=2; Synonyms=GP49B2 ; IsoId=Q64281-2; Sequence=VSP_002510, VSP_002511; Expressed on mast cells and natural killer cells (at protein level) (PubMed:8977169, PubMed:8977170, PubMed:11457897). Expressed on neutrophils (at protein level) (PubMed:14557414). Expressed on eosinophils (at protein level) (PubMed:17761953). Expressed on dendritic cells (at protein level) (PubMed:18792399). Expressed on memory and marginal zone B cells (at protein level) (PubMed:24935931). Expressed on CD8 T cells (at protein level) (PubMed:12682239). Expressed in the uterus of pregnant mice where it is detected at day 4.0 of pregnancy with levels dropping at day 4.5 (PubMed:9338594). Highly expressed in the luminal epithelium of uterine endometrium with lower levels in the glandular epithelium (PubMed:9338594). Induced by lipopolysaccharide on neutrophils (at protein level) (PubMed:14557414). Induced by IL6 and LIF (PubMed:9338594). Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Tyrosine phosphorylated. No effect on fertility or litter size (PubMed:10982834, PubMed:11457897). Normal development of mast cells and natural killer cells (PubMed:10982834). Increased severity of local and systemic anaphylactic reactions (PubMed:11457897). Significantly increased sensitivity to IgE-dependent passive cutaneous anaphylaxis with greater tissue swelling and mast cell degranulation, and significantly greater and faster death rate in active systemic anaphylaxis (PubMed:11457897). However, another study found no effect on mast cell activity with no increase in mast cell degranulation (PubMed:10982834). Macroscopic hemorrhages following intradermal injection of E.coli lipopolysaccharide with increased neutrophil numbers around the site of injection (PubMed:14557414). Normal B cell development and memory B cell formation but increased production by marginal zone and memory B cells of IgM after a primary immunization and of IgM, IgG1 and IgE after a secondary immunization (PubMed:24935931). Reduced ERK activation and reduced Prdm1/Blimp1 expression, indicative of suppression of plasma cell differentiation (PubMed:24935931). No effect on antigen uptake or cytokine production by dendritic cells but dendritic cells show enhanced antigen presentation to T cells and induce increased T cell stimulation (PubMed:18792399). Increased neutrophilia, eosinophilia and mast cell degranulation following ocular ragweed (RW) sensitization and challenge, and increased lung inflammation following RW sensitization and challenge (PubMed:17761953). Increased Kitlg/SCF-induced mast cell degranulation and tissue swelling (PubMed:12884301). Enhanced IFNG production by CD8 T cells, CD4 T cells and NK cells following viral infection (PubMed:12682239). neutrophil homeostasis adaptive immune response immune system process inflammatory response to antigenic stimulus plasma membrane inflammatory response blood coagulation response to wounding response to nematode external side of plasma membrane response to extracellular stimulus membrane integral component of membrane response to lipopolysaccharide CD4-positive, alpha-beta T cell proliferation CD8-positive, alpha-beta T cell proliferation type 2 immune response cytokine metabolic process chemokine metabolic process response to other organism cellular response to lipopolysaccharide uc011xdq.1 uc011xdq.2 uc011xdq.3 uc011xdq.4 uc011xdq.5 
ENSMUST00000220184.2 Gm10744 ENSMUST00000220184.2 Gm10744 (from geneSymbol) AK133293 ENSMUST00000220184.1 uc287vdg.1 uc287vdg.2 uc287vdg.1 uc287vdg.2 
ENSMUST00000220185.2 Or2at4 ENSMUST00000220185.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q518) E9Q518 E9Q518_MOUSE ENSMUST00000220185.1 Olfr520 Or2at4 uc291tai.1 uc291tai.2 Cell membrane ulti-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell positive regulation of ERK1 and ERK2 cascade uc291tai.1 uc291tai.2 
ENSMUST00000220193.2 Or5p51 ENSMUST00000220193.2 Potential odorant receptor. (from UniProt Q8VF65) ENSMUST00000220193.1 Mor204-22 O5P51_MOUSE Olfr470 Or5p51 Q8VF65 uc291ufn.1 uc291ufn.2 Potential odorant receptor. Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc291ufn.1 uc291ufn.2 
ENSMUST00000220196.2 Gm47702 ENSMUST00000220196.2 Gm47702 (from geneSymbol) ENSMUST00000220196.1 uc287qkd.1 uc287qkd.2 uc287qkd.1 uc287qkd.2 
ENSMUST00000220205.4 Gm47525 ENSMUST00000220205.4 Gm47525 (from geneSymbol) ENSMUST00000220205.1 ENSMUST00000220205.2 ENSMUST00000220205.3 LF199197 uc288hgo.1 uc288hgo.2 uc288hgo.3 uc288hgo.4 uc288hgo.1 uc288hgo.2 uc288hgo.3 uc288hgo.4 
ENSMUST00000220206.3 Gm47698 ENSMUST00000220206.3 Gm47698 (from geneSymbol) ENSMUST00000220206.1 ENSMUST00000220206.2 uc287prw.1 uc287prw.2 uc287prw.3 uc287prw.1 uc287prw.2 uc287prw.3 
ENSMUST00000220211.2 Gm36283 ENSMUST00000220211.2 Gm36283 (from geneSymbol) AK043717 ENSMUST00000220211.1 uc287usz.1 uc287usz.2 uc287usz.1 uc287usz.2 
ENSMUST00000220217.2 Gm48755 ENSMUST00000220217.2 Gm48755 (from geneSymbol) AK039629 ENSMUST00000220217.1 uc287plj.1 uc287plj.2 uc287plj.1 uc287plj.2 
ENSMUST00000220221.2 Gm46224 ENSMUST00000220221.2 Gm46224 (from geneSymbol) AK157440 ENSMUST00000220221.1 uc287rdk.1 uc287rdk.2 uc287rdk.1 uc287rdk.2 
ENSMUST00000220222.2 ENSMUSG00000121418 ENSMUST00000220222.2 predicted gene 5512 (from RefSeq NR_002891.1) ENSMUST00000220222.1 NR_002891 uc289rdm.1 uc289rdm.2 uc289rdm.1 uc289rdm.2 
ENSMUST00000220224.2 Gm47337 ENSMUST00000220224.2 Gm47337 (from geneSymbol) ENSMUST00000220224.1 uc287uts.1 uc287uts.2 uc287uts.1 uc287uts.2 
ENSMUST00000220227.2 Coq10a ENSMUST00000220227.2 coenzyme Q10A, transcript variant 2 (from RefSeq NM_001374700.2) A0A1W2P7J1 A0A1W2P7J1_MOUSE Coq10a ENSMUST00000220227.1 NM_001374700 uc287vsn.1 uc287vsn.2 Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. Interacts with coenzyme Q. Belongs to the COQ10 family. mitochondrion ubiquinone biosynthetic process cellular respiration ubiquinone binding uc287vsn.1 uc287vsn.2 
ENSMUST00000220233.3 Gm10754 ENSMUST00000220233.3 predicted gene 10754 (from RefSeq NR_033537.1) ENSMUST00000220233.1 ENSMUST00000220233.2 NR_033537 uc011xmh.1 uc011xmh.2 uc011xmh.3 uc011xmh.1 uc011xmh.2 uc011xmh.3 
ENSMUST00000220238.2 Susd6 ENSMUST00000220238.2 sushi domain containing 6, transcript variant 1 (from RefSeq NM_001242419.1) 4933426M11Rik ENSMUST00000220238.1 NM_001242419 Q8C0M5 Q8C0M5_MOUSE Susd6 uc007obj.1 uc007obj.2 uc007obj.3 uc007obj.4 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc007obj.1 uc007obj.2 uc007obj.3 uc007obj.4 
ENSMUST00000220240.2 Gm48779 ENSMUST00000220240.2 Gm48779 (from geneSymbol) ENSMUST00000220240.1 uc288ggi.1 uc288ggi.2 uc288ggi.1 uc288ggi.2 
ENSMUST00000220243.2 Gm48353 ENSMUST00000220243.2 Gm48353 (from geneSymbol) ENSMUST00000220243.1 uc287rrq.1 uc287rrq.2 uc287rrq.1 uc287rrq.2 
ENSMUST00000220244.2 Gm48718 ENSMUST00000220244.2 Gm48718 (from geneSymbol) ENSMUST00000220244.1 uc287ugz.1 uc287ugz.2 uc287ugz.1 uc287ugz.2 
ENSMUST00000220248.2 Gm33091 ENSMUST00000220248.2 predicted gene, 29684 (from RefSeq NR_131146.1) ENSMUST00000220248.1 NR_131146 uc056yhz.1 uc056yhz.2 uc056yhz.1 uc056yhz.2 
ENSMUST00000220254.2 Gm47342 ENSMUST00000220254.2 Gm47342 (from geneSymbol) AK086934 ENSMUST00000220254.1 uc287vdx.1 uc287vdx.2 uc287vdx.1 uc287vdx.2 
ENSMUST00000220255.2 Gm48511 ENSMUST00000220255.2 Gm48511 (from geneSymbol) AK047039 ENSMUST00000220255.1 uc288enn.1 uc288enn.2 uc288enn.1 uc288enn.2 
ENSMUST00000220256.3 Gm46212 ENSMUST00000220256.3 Gm46212 (from geneSymbol) ENSMUST00000220256.1 ENSMUST00000220256.2 uc287pri.1 uc287pri.2 uc287pri.3 uc287pri.1 uc287pri.2 uc287pri.3 
ENSMUST00000220264.2 Gm47415 ENSMUST00000220264.2 Gm47415 (from geneSymbol) AK046728 ENSMUST00000220264.1 uc288ilo.1 uc288ilo.2 uc288ilo.1 uc288ilo.2 
ENSMUST00000220268.2 Or7g26 ENSMUST00000220268.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BPT4) A0A2I3BPT4 A0A2I3BPT4_MOUSE ENSMUST00000220268.1 Olfr844 Or7g26 uc292etn.1 uc292etn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc292etn.1 uc292etn.2 
ENSMUST00000220278.2 Gm47016 ENSMUST00000220278.2 Gm47016 (from geneSymbol) DQ684736 ENSMUST00000220278.1 uc287rbc.1 uc287rbc.2 uc287rbc.1 uc287rbc.2 
ENSMUST00000220281.2 Gm48086 ENSMUST00000220281.2 Gm48086 (from geneSymbol) AK149535 ENSMUST00000220281.1 uc287rnc.1 uc287rnc.2 uc287rnc.1 uc287rnc.2 
ENSMUST00000220287.2 BC024063 ENSMUST00000220287.2 cDNA sequence BC024063, transcript variant 2 (from RefSeq NM_001374035.1) A0A1W2P7G7 A0A1W2P7G7_MOUSE BC024063 ENSMUST00000220287.1 NM_001374035 uc287tni.1 uc287tni.2 May be involved in transcriptional regulation. molecular_function nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc287tni.1 uc287tni.2 
ENSMUST00000220294.2 Gm35721 ENSMUST00000220294.2 predicted gene, 35721, transcript variant 2 (from RefSeq NR_168652.1) ENSMUST00000220294.1 NR_168652 uc287skc.1 uc287skc.2 uc287skc.1 uc287skc.2 
ENSMUST00000220296.2 Gm47760 ENSMUST00000220296.2 Gm47760 (from geneSymbol) ENSMUST00000220296.1 uc287psz.1 uc287psz.2 uc287psz.1 uc287psz.2 
ENSMUST00000220297.2 Apba3 ENSMUST00000220297.2 May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity). (from UniProt O88888) AK045965 APBA3_MOUSE ENSMUST00000220297.1 Mint3 O88888 Q3TDI1 Q8BR09 uc287thb.1 uc287thb.2 May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity). Binds to the cytoplasmic domain of amyloid protein (APP). Interacts with HIF1AN (via N-terminus) (By similarity). Interacts with NECAB3; seems to mediate the interaction between NECAB3 and HIF1AN (By similarity). Cytoplasm, perinuclear region Ubiquitous. Composed of an N-terminal domain, a middle phosphotyrosine- binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane. beta-amyloid binding in utero embryonic development enzyme inhibitor activity cytoplasm plasma membrane chemical synaptic transmission regulation of gene expression protein transport enzyme binding negative regulation of catalytic activity dendritic spine synapse perinuclear region of cytoplasm regulation of catalytic activity uc287thb.1 uc287thb.2 
ENSMUST00000220302.2 Nova2 ENSMUST00000220302.2 NOVA alternative splicing regulator 2 (from RefSeq NM_001029877.3) A0A1W2P872 D3YVV7 ENSMUST00000220302.1 NM_001029877 NOVA2_MOUSE Nova2 uc012fau.1 uc012fau.2 Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion. It binds specifically to the sequences 5'-YCAY- 3' and regulates splicing in only a subset of regulated exons (PubMed:14615540). Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion (PubMed:16041372). With NOVA1, they perform unique biological functions in different brain areas and cell types. Uniquely regulates alternative splicing events of a series of axon guidance related genes during cortical development, being essential for central nervous system development by regulating neural networks wiring (PubMed:27223325, PubMed:16041372). Regulates differentially alternative splicing on the same transcripts expressed in different neurons. This includes functional differences in transcripts expressed in cortical and cerebellar excitatory versus inhibitory neurons where is required for, respectively, development of laminar structure and motor coordination and synapse formation. Also the regulation the regulation of intron retention can sequester the trans-acting splicing factor PTBP2, acting as a variable cis-acting scaffolding platform for PTBP2 across various natural conditions (PubMed:30638744). Interacts with PTBP2; the interaction is direct. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=NOVA2 ; IsoId=A0A1W2P872-1; Sequence=Displayed; Name=2; Synonyms=SuperNOVA2 ; IsoId=A0A1W2P872-2; Sequence=VSP_061137; Expressed in brain cortex (PubMed:27223325). Expression is enriched in excitatory neuronal-linage (PubMed:30638744). Expression level is progressively up-regulated during neural differentiation from neural progenitor cells at 12.5 dpc to 18.5 dpc. The third KH domain (KH3) recognizes specifically 5'-YCAY-3'. Knockouts are born indistinguishable from littermates but failed to thrive, demonstrating progressive motor dysfunction and overt motor weakness, and they die an average of 14-18 days after birth. They have agenesis of the corpus callosum, and axonal outgrowth defects specific to ventral motoneuron axons and efferent innervation of the cochlea (PubMed:27223325). Conditional knockouts in excitatory neurons die between three and four weeks old and show disorganized cortical and hippocampal CA1 and CA3 laminar structure. Conditional knockouts in inhibitory neurons show no neuronal migration or position abnormality. They display reduced thickness of CA1 stratum lacunosum-moleculare (SLM) and dentate gyrus molecular layer (PubMed:30638744). Conditional knockouts in Purkinje cells have progressive motor discoordination and cerebellar atrophy. They show a marked defect in dendritic morphology, Purkinje cells degeneration, loss of synaptic layer thickness accompanied by neuritic swelling and reduced spine density (PubMed:30638744). mRNA splicing, via spliceosome nucleic acid binding RNA binding regulation of RNA metabolic process uc012fau.1 uc012fau.2 
ENSMUST00000220312.2 Tbxa2r ENSMUST00000220312.2 thromboxane A2 receptor, transcript variant 1 (from RefSeq NM_009325.4) ENSMUST00000220312.1 NM_009325 Q5FW61 Q5FW61_MOUSE Tbxa2r tp uc007ghg.1 uc007ghg.2 uc007ghg.3 uc007ghg.4 This gene encodes a multi-pass membrane protein that functions as a G-protein coupled receptor. The encoded protein binds thromboxane A2, resulting in the aggregation of platelets and constriction of blood vessels. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Mar 2013]. Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein acrosomal vesicle G-protein coupled receptor activity thromboxane receptor activity plasma membrane G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration response to nutrient membrane integral component of membrane nuclear speck positive regulation of blood coagulation response to testosterone response to drug response to ethanol positive regulation of angiogenesis positive regulation of blood pressure positive regulation of vasoconstriction cellular response to lipopolysaccharide negative regulation of cell migration involved in sprouting angiogenesis uc007ghg.1 uc007ghg.2 uc007ghg.3 uc007ghg.4 
ENSMUST00000220313.2 Gm47595 ENSMUST00000220313.2 Gm47595 (from geneSymbol) ENSMUST00000220313.1 uc287rne.1 uc287rne.2 uc287rne.1 uc287rne.2 
ENSMUST00000220314.2 Gm32687 ENSMUST00000220314.2 predicted gene, 32687, transcript variant 2 (from RefSeq NM_001374223.1) A0A1W2P6H7 A0A1W2P6H7_MOUSE ENSMUST00000220314.1 Gm32687 NM_001374223 uc287tms.1 uc287tms.2 nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc287tms.1 uc287tms.2 
ENSMUST00000220315.2 Gm48210 ENSMUST00000220315.2 Gm48210 (from geneSymbol) ENSMUST00000220315.1 uc288eqg.1 uc288eqg.2 uc288eqg.1 uc288eqg.2 
ENSMUST00000220316.2 Gm47765 ENSMUST00000220316.2 Gm47765 (from geneSymbol) ENSMUST00000220316.1 uc288hmf.1 uc288hmf.2 uc288hmf.1 uc288hmf.2 
ENSMUST00000220339.2 Gm20758 ENSMUST00000220339.2 predicted gene, 20758 (from RefSeq NR_046029.1) ENSMUST00000220339.1 NR_046029 uc029rfo.1 uc029rfo.2 uc029rfo.1 uc029rfo.2 
ENSMUST00000220346.2 Cep290 ENSMUST00000220346.2 centrosomal protein 290, transcript variant 2 (from RefSeq NM_146009.4) Cep290 E9Q9M0 E9Q9M0_MOUSE ENSMUST00000220346.1 NM_146009 uc287unb.1 uc287unb.2 Cytoplasm, cytoskeleton, cilium basal body gamma-tubulin complex nucleus cytoplasm centrosome centriole cytosol macromolecular complex centriolar satellite ciliary transition zone ciliary basal body identical protein binding positive regulation of transcription, DNA-templated cilium assembly regulation of establishment of protein localization positive regulation of intracellular protein transport uc287unb.1 uc287unb.2 
ENSMUST00000220360.2 Gm48790 ENSMUST00000220360.2 Gm48790 (from geneSymbol) ENSMUST00000220360.1 uc288evs.1 uc288evs.2 uc288evs.1 uc288evs.2 
ENSMUST00000220361.2 Gm48798 ENSMUST00000220361.2 Gm48798 (from geneSymbol) AK138776 ENSMUST00000220361.1 uc287poo.1 uc287poo.2 uc287poo.1 uc287poo.2 
ENSMUST00000220363.3 Gm47895 ENSMUST00000220363.3 Gm47895 (from geneSymbol) ENSMUST00000220363.1 ENSMUST00000220363.2 uc287rur.1 uc287rur.2 uc287rur.3 uc287rur.1 uc287rur.2 uc287rur.3 
ENSMUST00000220364.3 Gm46204 ENSMUST00000220364.3 Gm46204 (from geneSymbol) ENSMUST00000220364.1 ENSMUST00000220364.2 KY467558 uc287vgu.1 uc287vgu.2 uc287vgu.3 uc287vgu.1 uc287vgu.2 uc287vgu.3 
ENSMUST00000220377.2 Usp15 ENSMUST00000220377.2 ubiquitin specific peptidase 15, transcript variant 1 (from RefSeq NM_027604.4) ENSMUST00000220377.1 Kiaa0529 NM_027604 Q3TGF5 Q3TTB2 Q3UL25 Q3UZH0 Q80TY6 Q80UK9 Q8R5H1 UBP15_MOUSE uc007hgn.1 uc007hgn.2 uc007hgn.3 uc007hgn.4 The protein encoded by this gene is a member of the large ubiquitin specific protease (Usp) family of proteins. These proteins are known to cleave ubiquitin, and contain a conserved cysteine residue (Cys box) and two conserved histidine residues (His box) that are thought to form part of the active site of the protease. This protein has been shown to cleave both the ubiquitin-proline and the ubiquitin-methionine bonds in vitro. This protein is thought to regulate many cellular processes through its deubiquitination activity, including the transforming growth factor beta (TGF-beta) pathway. Cardiac-specific overexpression of the human ortholog of this gene in mice causes enlargement of the heart that is more pronounced in the atrium than in the ventricle. This gene has two pseudogenes on chromosome 14. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms.[provided by RefSeq, Aug 2014]. Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B. Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys- 48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery. Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9. Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in vivo. Identified in a complex with the COP9 signalosome complex (CSN). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct. Forms a complex with SMURF2 and SMAD7. Interacts with TGFBR1. Interacts with SART3; the interaction is direct. May interact with RNF20 and RNF40. May interact with PRKN. Interacts with INCA1. Cytoplasm Nucleus Mitochondrion Event=Alternative splicing; Named isoforms=5; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q8R5H1-1; Sequence=Displayed; Name=2; IsoId=Q8R5H1-2; Sequence=VSP_005262, VSP_005263; Name=3; IsoId=Q8R5H1-3; Sequence=VSP_005264; Name=4; IsoId=Q8R5H1-4; Sequence=VSP_005265, VSP_005266; Name=5; IsoId=Q8R5H1-5; Sequence=VSP_005263; Widely expressed with highest levels in the brain and spleen, and lowest levels in the muscles (at protein level) (PubMed:24852371). In the midbrain, strong expression in neurons including the dopaminergic neurons (at protein level) (PubMed:24852371). Widely expressed with highest levels in testis, heart and liver (PubMed:12532266). Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome. Ubiquitinated, leading to degradation by the proteasome. Belongs to the peptidase C19 family. Sequence=BAC65583.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=EDL24441.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; catalytic activity cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity transforming growth factor beta receptor binding nucleus cytoplasm mitochondrion cytosol proteolysis ubiquitin-dependent protein catabolic process transforming growth factor beta receptor signaling pathway peptidase activity cysteine-type peptidase activity protein deubiquitination hydrolase activity BMP signaling pathway monoubiquitinated protein deubiquitination histone H2B conserved C-terminal lysine deubiquitination thiol-dependent ubiquitinyl hydrolase activity identical protein binding SMAD binding pathway-restricted SMAD protein phosphorylation ubiquitinated histone binding uc007hgn.1 uc007hgn.2 uc007hgn.3 uc007hgn.4 
ENSMUST00000220378.2 ENSMUSG00000121658 ENSMUST00000220378.2 ENSMUSG00000121658 (from geneSymbol) AK052706 ENSMUST00000220378.1 uc287vik.1 uc287vik.2 uc287vik.1 uc287vik.2 
ENSMUST00000220380.2 Gm47164 ENSMUST00000220380.2 Gm47164 (from geneSymbol) AK045941 ENSMUST00000220380.1 uc287upq.1 uc287upq.2 uc287upq.1 uc287upq.2 
ENSMUST00000220385.3 Gm47944 ENSMUST00000220385.3 Gm47944 (from geneSymbol) ENSMUST00000220385.1 ENSMUST00000220385.2 uc287spv.1 uc287spv.2 uc287spv.3 uc287spv.1 uc287spv.2 uc287spv.3 
ENSMUST00000220387.2 Gm47673 ENSMUST00000220387.2 Gm47673 (from geneSymbol) ENSMUST00000220387.1 LF222339 uc287umx.1 uc287umx.2 uc287umx.1 uc287umx.2 
ENSMUST00000220394.2 Or10x1 ENSMUST00000220394.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt F8VQB1) ENSMUST00000220394.1 F8VQB1 F8VQB1_MOUSE Olfr417 Or10x1 uc287ocn.1 uc287ocn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc287ocn.1 uc287ocn.2 
ENSMUST00000220397.2 Gm10764 ENSMUST00000220397.2 Gm10764 (from geneSymbol) ENSMUST00000220397.1 uc287tvq.1 uc287tvq.2 uc287tvq.1 uc287tvq.2 
ENSMUST00000220398.2 Gm49454 ENSMUST00000220398.2 Gm49454 (from geneSymbol) ENSMUST00000220398.1 uc287rvp.1 uc287rvp.2 uc287rvp.1 uc287rvp.2 
ENSMUST00000220420.2 Gm47025 ENSMUST00000220420.2 Gm47025 (from geneSymbol) AK045941 ENSMUST00000220420.1 uc287uou.1 uc287uou.2 uc287uou.1 uc287uou.2 
ENSMUST00000220423.2 Gm47941 ENSMUST00000220423.2 Gm47941 (from geneSymbol) ENSMUST00000220423.1 uc288hnp.1 uc288hnp.2 uc288hnp.1 uc288hnp.2 
ENSMUST00000220425.2 Gm47009 ENSMUST00000220425.2 Gm47009 (from geneSymbol) ENSMUST00000220425.1 uc287vep.1 uc287vep.2 uc287vep.1 uc287vep.2 
ENSMUST00000220426.2 Gm47896 ENSMUST00000220426.2 Gm47896 (from geneSymbol) ENSMUST00000220426.1 uc287rus.1 uc287rus.2 uc287rus.1 uc287rus.2 
ENSMUST00000220435.3 Gm48748 ENSMUST00000220435.3 Gm48748 (from geneSymbol) ENSMUST00000220435.1 ENSMUST00000220435.2 uc287ple.1 uc287ple.2 uc287ple.3 uc287ple.1 uc287ple.2 uc287ple.3 
ENSMUST00000220436.2 Gm47641 ENSMUST00000220436.2 Gm47641 (from geneSymbol) ENSMUST00000220436.1 uc287rfp.1 uc287rfp.2 uc287rfp.1 uc287rfp.2 
ENSMUST00000220438.2 4930444K16Rik ENSMUST00000220438.2 4930444K16Rik (from geneSymbol) AK015382 ENSMUST00000220438.1 uc287pqq.1 uc287pqq.2 uc287pqq.1 uc287pqq.2 
ENSMUST00000220440.2 Gstt2 ENSMUST00000220440.2 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (from UniProt Q61133) AK158939 ENSMUST00000220440.1 GSTT2_MOUSE Gstt2 Q61133 Q61134 Q64472 Q91VB0 uc287shd.1 uc287shd.2 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=; Homodimer. Cytoplasm, cytosol Nucleus In liver, highest expression found in central vein limiting plate hepatocytes. Also expressed in interlobular bile duct epithelial cells. In lung, expressed in club cells and ciliated cells of the bronchiolar epithelium and in type II alveolar cells of the lung parenchyma. Belongs to the GST superfamily. Theta family. glutathione transferase activity glutathione peroxidase activity nucleus nucleoplasm cytoplasm cytosol glutathione metabolic process transferase activity cellular oxidant detoxification cellular response to leukemia inhibitory factor uc287shd.1 uc287shd.2 
ENSMUST00000220443.2 Cep85l ENSMUST00000220443.2 centrosomal protein 85-like (from RefSeq NM_001204983.2) A0A1W2P884 CE85L_MOUSE Cep85l ENSMUST00000220443.1 NM_001204983 uc007fbn.1 uc007fbn.2 uc007fbn.3 uc007fbn.4 Plays an essential role in neuronal cell migration. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localized specifically to the pericentriolar region. Knockdown of the expression into neural stem cells of the mouse neocortex causes a neuronal migration defect. Belongs to the CEP85 family. molecular_function centrosome biological_process uc007fbn.1 uc007fbn.2 uc007fbn.3 uc007fbn.4 
ENSMUST00000220444.2 Gm48308 ENSMUST00000220444.2 Gm48308 (from geneSymbol) ENSMUST00000220444.1 uc287twd.1 uc287twd.2 uc287twd.1 uc287twd.2 
ENSMUST00000220447.2 Ippk ENSMUST00000220447.2 inositol 1,3,4,5,6-pentakisphosphate 2-kinase, transcript variant 4 (from RefSeq NR_165080.1) ENSMUST00000220447.1 IPPK_MOUSE NR_165080 Q3V3Z0 Q6P1C1 uc007qjj.1 uc007qjj.2 uc007qjj.3 uc007qjj.4 Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. Reaction=1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo- inositol hexakisphosphate + ADP + H(+); Xref=Rhea:RHEA:20313, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57733, ChEBI:CHEBI:58130, ChEBI:CHEBI:456216; EC=2.7.1.158; Cytoplasm Nucleus In brain, it is expressed throughout the hippocampus (CA1, CA2, CA3 and dentate gyrus), inner layers of the cerebral cortex, and Purkinje cells of the cerebellum. In heart, it is expressed in cardiomyocytes but not in interstitial cells, blood vessels, or valves. Also expressed in testis. In 9 dpc embryos it is expressed in regions corresponding to the neural tube, notochord and somites. Through the neural tube, it is expressed in the ventricular zone and in migrating neuroblasts. Also expressed in the notochord and specific regions of the somite. Strongly expressed in the myotome (future skeletal muscle) of the somite. In addition to the neural tube, it is also expressed in the ventricular zone and migrating neuroblasts throughout the embryonic brain. Prominent expression is detected in the yolk sac and embryonic heart. Within the yolk sac, it is expressed in both the epithelial and endothelial layers (blood vessels) but absent from the blood islands. In the heart, it is detected in both the atrial and ventricular chambers. In the ventricular myocardium it is present in both the endocardium and myocardium. Also expressed in the cardinal vein, aorta, digestive tract, and pharyngeal arches. The EXKPK motif is conserved in inositol-pentakisphosphate 2- kinases of both family 1 and 2. Death during ermbryogenesis before 8.5 dpc, suggesting that InsP6 is required for yolk sac function and development. Belongs to the IPK1 type 2 family. nucleotide binding ATP binding nucleus nucleolus cytoplasm kinase activity phosphorylation transferase activity inositol phosphate biosynthetic process inositol pentakisphosphate 2-kinase activity inositol phosphorylation binding, bridging positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter uc007qjj.1 uc007qjj.2 uc007qjj.3 uc007qjj.4 
ENSMUST00000220449.2 Btf3l4b ENSMUST00000220449.2 Belongs to the NAC-beta family. (from UniProt Q9CQH7) BC138215 BT3L4_MOUSE Btf3l4 ENSMUST00000220449.1 Q9CQH7 uc288pgv.1 uc288pgv.2 Belongs to the NAC-beta family. cellular_component biological_process uc288pgv.1 uc288pgv.2 
ENSMUST00000220472.2 Gm47859 ENSMUST00000220472.2 Gm47859 (from geneSymbol) ENSMUST00000220472.1 uc288gaw.1 uc288gaw.2 uc288gaw.1 uc288gaw.2 
ENSMUST00000220476.2 Gm47588 ENSMUST00000220476.2 Gm47588 (from geneSymbol) AK048384 ENSMUST00000220476.1 uc288nth.1 uc288nth.2 uc288nth.1 uc288nth.2 
ENSMUST00000220477.2 D430020J02Rik ENSMUST00000220477.2 RIKEN cDNA D430020J02 gene (from RefSeq NR_028421.1) ENSMUST00000220477.1 NR_028421 uc007phs.1 uc007phs.2 uc007phs.3 uc007phs.4 uc007phs.1 uc007phs.2 uc007phs.3 uc007phs.4 
ENSMUST00000220499.3 Eif1ad12 ENSMUST00000220499.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. (from UniProt A0A1Y7VK80) A0A1Y7VK80 A0A1Y7VK80_MOUSE ENSMUST00000220499.1 ENSMUST00000220499.2 Eif1ad12 uc288idt.1 uc288idt.2 uc288idt.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. RNA binding translation initiation factor activity translation translational initiation uc288idt.1 uc288idt.2 uc288idt.3 
ENSMUST00000220507.2 Gm40893 ENSMUST00000220507.2 predicted gene, 40893 (from RefSeq NR_136759.1) ENSMUST00000220507.1 NR_136759 uc007oqy.1 uc007oqy.2 uc007oqy.1 uc007oqy.2 
ENSMUST00000220518.2 Zfhx3 ENSMUST00000220518.2 Nucleus (from UniProt E9QMD3) D26046 E9QMD3 E9QMD3_MOUSE ENSMUST00000220518.1 Zfhx3 uc292dbw.1 uc292dbw.2 Nucleus negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleic acid binding DNA binding nucleus transcription factor complex cytoplasm regulation of transcription, DNA-templated cell cycle arrest brain development zinc ion binding nuclear body enzyme binding sequence-specific DNA binding regulation of neuron differentiation positive regulation of transcription, DNA-templated metal ion binding response to transforming growth factor beta uc292dbw.1 uc292dbw.2 
ENSMUST00000220520.2 Gm49732 ENSMUST00000220520.2 Gm49732 (from geneSymbol) ENSMUST00000220520.1 uc288ixl.1 uc288ixl.2 uc288ixl.1 uc288ixl.2 
ENSMUST00000220524.2 Gm47606 ENSMUST00000220524.2 Gm47606 (from geneSymbol) AK157450 ENSMUST00000220524.1 uc288lcx.1 uc288lcx.2 uc288lcx.1 uc288lcx.2 
ENSMUST00000220527.2 Gm36752 ENSMUST00000220527.2 Gm36752 (from geneSymbol) ENSMUST00000220527.1 uc288fdi.1 uc288fdi.2 uc288fdi.1 uc288fdi.2 
ENSMUST00000220528.3 Ubl5b ENSMUST00000220528.3 ubiquitin-like 5B (from RefSeq NM_001166062.2) A0A1Y7VKT9 A0A1Y7VKT9_MOUSE ENSMUST00000220528.1 ENSMUST00000220528.2 Gm16381 Gm2001 NM_001166062 Ubl5b Ubl5c uc033gel.1 uc033gel.2 uc033gel.3 uc033gel.4 mRNA splicing, via spliceosome molecular_function cellular_component nucleus cytoplasm cellular protein modification process biological_process protein tag uc033gel.1 uc033gel.2 uc033gel.3 uc033gel.4 
ENSMUST00000220540.2 ENSMUSG00000121676 ENSMUST00000220540.2 ENSMUSG00000121676 (from geneSymbol) ENSMUST00000220540.1 uc288kkh.1 uc288kkh.2 uc288kkh.1 uc288kkh.2 
ENSMUST00000220545.2 4921511I17Rik ENSMUST00000220545.2 RIKEN cDNA 4921511I17 gene (from RefSeq NR_045829.1) ENSMUST00000220545.1 NR_045829 uc288eyh.1 uc288eyh.2 uc288eyh.1 uc288eyh.2 
ENSMUST00000220564.2 Gm47155 ENSMUST00000220564.2 Gm47155 (from geneSymbol) AK047247 ENSMUST00000220564.1 uc288pea.1 uc288pea.2 uc288pea.1 uc288pea.2 
ENSMUST00000220575.2 Gm34237 ENSMUST00000220575.2 Gm34237 (from geneSymbol) ENSMUST00000220575.1 uc288eya.1 uc288eya.2 uc288eya.1 uc288eya.2 
ENSMUST00000220578.2 Srp54a ENSMUST00000220578.2 signal recognition particle 54A, transcript variant 9 (from RefSeq NR_182180.1) ENSMUST00000220578.1 NR_182180 P14576 Q3UWX8 Q9CWH7 Q9D008 SRP54_MOUSE Srp54 uc007nof.1 uc007nof.2 uc007nof.3 Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity). Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=; Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). Interacts with RNPS1 (By similarity). Interacts with the SRP receptor subunit SRPRA (By similarity). Nucleus speckle Cytoplasm Endoplasmic reticulum Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14576-1; Sequence=Displayed; Name=2; IsoId=P14576-2; Sequence=VSP_014953, VSP_014954; The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity). The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins. Belongs to the GTP-binding SRP family. SRP54 subfamily. nucleotide binding RNA binding GTPase activity GTP binding nucleus cytoplasm signal recognition particle, endoplasmic reticulum targeting cytosol SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane, translocation drug binding 7S RNA binding nuclear speck GDP binding endoplasmic reticulum signal peptide binding ribonucleoprotein complex binding signal recognition particle nucleolus uc007nof.1 uc007nof.2 uc007nof.3 
ENSMUST00000220585.3 Eif1ad4 ENSMUST00000220585.3 eukaryotic translation initiation factor 1A domain containing 4 (from RefSeq NM_001177574.1) A0A1Y7VLT7 A0A1Y7VLT7_MOUSE ENSMUST00000220585.1 ENSMUST00000220585.2 Eif1ad4 NM_001177574 uc288ier.1 uc288ier.2 uc288ier.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. RNA binding translation initiation factor activity translation translational initiation uc288ier.1 uc288ier.2 uc288ier.3 
ENSMUST00000220599.2 Gm47493 ENSMUST00000220599.2 Gm47493 (from geneSymbol) DQ712541 ENSMUST00000220599.1 uc288krx.1 uc288krx.2 uc288krx.1 uc288krx.2 
ENSMUST00000220600.2 Gm47259 ENSMUST00000220600.2 Gm47259 (from geneSymbol) ENSMUST00000220600.1 uc288lsj.1 uc288lsj.2 uc288lsj.1 uc288lsj.2 
ENSMUST00000220604.2 Gm48262 ENSMUST00000220604.2 Gm48262 (from geneSymbol) AK140294 ENSMUST00000220604.1 uc288knd.1 uc288knd.2 uc288knd.1 uc288knd.2 
ENSMUST00000220610.2 Gm40538 ENSMUST00000220610.2 Gm40538 (from geneSymbol) ENSMUST00000220610.1 uc288iie.1 uc288iie.2 uc288iie.1 uc288iie.2 
ENSMUST00000220613.2 Gm17611 ENSMUST00000220613.2 Gm17611 (from geneSymbol) AB045716 ENSMUST00000220613.1 uc288msz.1 uc288msz.2 uc288msz.1 uc288msz.2 
ENSMUST00000220621.2 Mrpl32 ENSMUST00000220621.2 mitochondrial ribosomal protein L32 (from RefSeq NM_029271.2) ENSMUST00000220621.1 Heg1 NM_029271 Q91XR6 Q9DCI9 RM32_MOUSE uc007pnk.1 uc007pnk.2 uc007pnk.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the bacterial ribosomal protein bL32 family. Sequence=AAK69482.1; Type=Erroneous initiation; Evidence=; structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation large ribosomal subunit uc007pnk.1 uc007pnk.2 uc007pnk.3 
ENSMUST00000220644.2 Gm5953 ENSMUST00000220644.2 Gm5953 (from geneSymbol) AK135500 ENSMUST00000220644.1 uc288ffw.1 uc288ffw.2 uc288ffw.1 uc288ffw.2 
ENSMUST00000220651.2 Gm19327 ENSMUST00000220651.2 Gm19327 (from geneSymbol) ENSMUST00000220651.1 uc288htv.1 uc288htv.2 uc288htv.1 uc288htv.2 
ENSMUST00000220661.2 Gm47585 ENSMUST00000220661.2 Gm47585 (from geneSymbol) ENSMUST00000220661.1 uc288nsh.1 uc288nsh.2 uc288nsh.1 uc288nsh.2 
ENSMUST00000220664.2 Gm48301 ENSMUST00000220664.2 Gm48301 (from geneSymbol) ENSMUST00000220664.1 uc288gqk.1 uc288gqk.2 uc288gqk.1 uc288gqk.2 
ENSMUST00000220666.3 Gm48190 ENSMUST00000220666.3 Gm48190 (from geneSymbol) AK029587 ENSMUST00000220666.1 ENSMUST00000220666.2 uc007qmr.1 uc007qmr.2 uc007qmr.3 uc007qmr.1 uc007qmr.2 uc007qmr.3 
ENSMUST00000220671.2 Gm49602 ENSMUST00000220671.2 Gm49602 (from geneSymbol) ENSMUST00000220671.1 LF199363 uc288kfs.1 uc288kfs.2 uc288kfs.1 uc288kfs.2 
ENSMUST00000220673.2 Gm48662 ENSMUST00000220673.2 Gm48662 (from geneSymbol) ENSMUST00000220673.1 uc288lth.1 uc288lth.2 uc288lth.1 uc288lth.2 
ENSMUST00000220675.3 Gm47116 ENSMUST00000220675.3 Gm47116 (from geneSymbol) ENSMUST00000220675.1 ENSMUST00000220675.2 uc288inv.1 uc288inv.2 uc288inv.3 uc288inv.1 uc288inv.2 uc288inv.3 
ENSMUST00000220689.2 Nin ENSMUST00000220689.2 ninein, transcript variant 8 (from RefSeq NR_175597.1) A0A1Y7VJL5 B2RQ73 B7ZMZ9 E9Q488 E9Q4S3 ENSMUST00000220689.1 Kiaa1565 NIN_MOUSE NR_175597 Nin Q61043 Q674R4 Q6ZPM7 uc288gyt.1 uc288gyt.2 Centrosomal protein required for the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15784680, PubMed:10934040). May also act as a centrosome maturation factor (By similarity). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15784680). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (By similarity). Required for centriole organization and microtubule anchoring at the mother centriole (By similarity). Homooligomer (By similarity). Interacts with GSK3B/GSK3-beta via its C-terminal domain (By similarity). Interacts with C14ORF166, such interaction may prevent its phosphorylation by GSK3B (By similarity). Interacts with AUNIP (via N-terminus) (By similarity). Identified in a complex with AUNIP and AURKA (By similarity). Interacts with CCDC120 (By similarity). Interacts (via C-terminus) with CEP250 (PubMed:27565344). Interacts with CEP170 (PubMed:27565344). Interacts (via N-terminus) with the gamma-tubulin ring complex component TUBGCP3 (PubMed:15784680). Interacts with gamma-tubulin (PubMed:15784680). Isoform 4 does not interact with CEP170 or CEP250 (PubMed:27565344). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome toplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Component of the core centrosome. Arranged in a tubular conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present only at the closed end. Requires PCM1 for centrosome localization. Localizes to the subdistal appendage region of the centriole in a DCTN1-dependent manner. [Isoform 4]: Cytoplasm Note=Seems to have a dominant-negative effect on localization of other isoforms, promoting their dissociation from the centrosome. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=NPC-CT ; IsoId=Q61043-3; Sequence=Displayed; Name=2; IsoId=Q61043-2; Sequence=VSP_059555, VSP_059556; Name=3; IsoId=Q61043-1; Sequence=VSP_059552, VSP_059555, VSP_059556; Name=4; Synonyms=Neuron ; IsoId=Q61043-4; Sequence=VSP_059551, VSP_059553, VSP_059554; Widely expressed. Highly expressed in spleen, bone marrow and skin. Weakly expressed in liver and small intestine. Expressed in brain. Associated with the centrosome throughout the cell cycle (PubMed:8834802). During mitosis, it is associated with the centrosome and the mitotic spindle (PubMed:8834802). At anaphase, it is only localized to centrosomes (PubMed:8834802). Isoform 4 is highly expressed in postmitotic cortical neurons during neurogenesis (PubMed:27565344). There is conflicting information regarding the regions required for centrosomal localization (PubMed:15784680). One study shows that the region 1591-1671 is necessary and sufficient for targeting to the centrosome (By similarity). Another study shows that a separate region within the coiled-coil domain, 1279-1565, is important for centrosomal localization (By similarity). However, a third study shows that the coiled-coil region (373-1874) is not sufficient for centrosomal localization and instead localizes to cytoplasmic speckles (PubMed:15784680). The observed differences might be due to oligomerization of the longer coiled-coil domain-containing sequence, which would mask the shorter centrosomal targeting sequences (PubMed:15784680). The N-terminal domain is important for targeting to the mother centriole, although it is not sufficient by itself for centrosomal localization. Phosphorylated by AURKA/Aurora kinase A and PKA kinases but not CK2 or AURKB/Aurora kinase B. Sequence=AAA83234.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAC98204.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; [Isoform 2]: Sequence=AAA83234.1; Type=Frameshift; Evidence=; nucleotide binding pericentriolar material spindle pole calcium ion binding protein binding GTP binding nucleus nucleolus cytoplasm centrosome centriole microtubule organizing center cytoskeleton microtubule plasma membrane protein localization centriole-centriole cohesion kinase binding corpus callosum morphogenesis corticospinal tract morphogenesis axon dendrite positive regulation of microtubule polymerization microtubule anchoring at centrosome microtubule minus-end axonal growth cone apical part of cell collateral sprouting positive regulation of axonogenesis centrosome localization mitotic spindle centrosome-templated microtubule nucleation mitotic spindle pole ciliary transition fiber uc288gyt.1 uc288gyt.2 
ENSMUST00000220690.2 Gm47806 ENSMUST00000220690.2 Gm47806 (from geneSymbol) ENSMUST00000220690.1 uc288lec.1 uc288lec.2 uc288lec.1 uc288lec.2 
ENSMUST00000220696.2 Gm48624 ENSMUST00000220696.2 Gm48624 (from geneSymbol) ENSMUST00000220696.1 LF199406 uc288kzy.1 uc288kzy.2 uc288kzy.1 uc288kzy.2 
ENSMUST00000220700.2 2900024D18Rik ENSMUST00000220700.2 2900024D18Rik (from geneSymbol) AK013581 ENSMUST00000220700.1 uc288kmh.1 uc288kmh.2 uc288kmh.1 uc288kmh.2 
ENSMUST00000220709.2 ENSMUSG00000121633 ENSMUST00000220709.2 ENSMUSG00000121633 (from geneSymbol) ENSMUST00000220709.1 LF241690 uc288fet.1 uc288fet.2 uc288fet.1 uc288fet.2 
ENSMUST00000220732.2 Gm48699 ENSMUST00000220732.2 Gm48699 (from geneSymbol) ENSMUST00000220732.1 uc288npr.1 uc288npr.2 uc288npr.1 uc288npr.2 
ENSMUST00000220739.2 Gm48799 ENSMUST00000220739.2 Gm48799 (from geneSymbol) ENSMUST00000220739.1 uc288lan.1 uc288lan.2 uc288lan.1 uc288lan.2 
ENSMUST00000220741.2 Gm47249 ENSMUST00000220741.2 Gm47249 (from geneSymbol) ENSMUST00000220741.1 uc288nxv.1 uc288nxv.2 uc288nxv.1 uc288nxv.2 
ENSMUST00000220745.2 Gm47545 ENSMUST00000220745.2 Gm47545 (from geneSymbol) ENSMUST00000220745.1 uc288gwg.1 uc288gwg.2 uc288gwg.1 uc288gwg.2 
ENSMUST00000220747.2 Gm47701 ENSMUST00000220747.2 Gm47701 (from geneSymbol) ENSMUST00000220747.1 LF220572 uc288fnz.1 uc288fnz.2 uc288fnz.1 uc288fnz.2 
ENSMUST00000220753.3 Gm34662 ENSMUST00000220753.3 Gm34662 (from geneSymbol) ENSMUST00000220753.1 ENSMUST00000220753.2 uc288gam.1 uc288gam.2 uc288gam.3 uc288gam.1 uc288gam.2 uc288gam.3 
ENSMUST00000220757.3 Gm20063 ENSMUST00000220757.3 predicted gene, 20063 (from RefSeq NR_045049.1) ENSMUST00000220757.1 ENSMUST00000220757.2 NR_045049 uc007nql.1 uc007nql.2 uc007nql.3 uc007nql.1 uc007nql.2 uc007nql.3 
ENSMUST00000220762.2 Gm47208 ENSMUST00000220762.2 Gm47208 (from geneSymbol) ENSMUST00000220762.1 uc288iou.1 uc288iou.2 uc288iou.1 uc288iou.2 
ENSMUST00000220764.2 Gm48621 ENSMUST00000220764.2 Gm48621 (from geneSymbol) AK038297 ENSMUST00000220764.1 uc288kzt.1 uc288kzt.2 uc288kzt.1 uc288kzt.2 
ENSMUST00000220768.2 A030005L19Rik ENSMUST00000220768.2 A030005L19Rik (from geneSymbol) A030005L19Rik A0A1Y7VIU2 A0A1Y7VIU2_MOUSE AK020696 ENSMUST00000220768.1 uc287jta.1 uc287jta.2 molecular_function cellular_component biological_process uc287jta.1 uc287jta.2 
ENSMUST00000220772.2 ENSMUSG00000121338 ENSMUST00000220772.2 ENSMUSG00000121338 (from geneSymbol) ENSMUST00000220772.1 uc288flu.1 uc288flu.2 uc288flu.1 uc288flu.2 
ENSMUST00000220773.2 Spata31e1 ENSMUST00000220773.2 Membrane ; Single- pass membrane protein (from UniProt A0A1Y7VN40) A0A1Y7VN40 A0A1Y7VN40_MOUSE ENSMUST00000220773.1 Gm30302 Spata31e1 uc288msl.1 uc288msl.2 Membrane ; Single- pass membrane protein Belongs to the SPATA31 family. membrane integral component of membrane uc288msl.1 uc288msl.2 
ENSMUST00000220775.2 Gm48890 ENSMUST00000220775.2 Gm48890 (from geneSymbol) ENSMUST00000220775.1 uc288koz.1 uc288koz.2 uc288koz.1 uc288koz.2 
ENSMUST00000220779.3 Gm28465 ENSMUST00000220779.3 Gm28465 (from geneSymbol) ENSMUST00000220779.1 ENSMUST00000220779.2 uc288kln.1 uc288kln.2 uc288kln.3 uc288kln.1 uc288kln.2 uc288kln.3 
ENSMUST00000220780.3 Gm36236 ENSMUST00000220780.3 Gm36236 (from geneSymbol) ENSMUST00000220780.1 ENSMUST00000220780.2 uc288fnr.1 uc288fnr.2 uc288fnr.3 uc288fnr.1 uc288fnr.2 uc288fnr.3 
ENSMUST00000220782.2 Gm40557 ENSMUST00000220782.2 Gm40557 (from geneSymbol) ENSMUST00000220782.1 uc288ipy.1 uc288ipy.2 uc288ipy.1 uc288ipy.2 
ENSMUST00000220785.2 Gm48133 ENSMUST00000220785.2 Gm48133 (from geneSymbol) ENSMUST00000220785.1 uc288phs.1 uc288phs.2 uc288phs.1 uc288phs.2 
ENSMUST00000220789.2 Gm47898 ENSMUST00000220789.2 Gm47898 (from geneSymbol) AK044542 ENSMUST00000220789.1 uc289oih.1 uc289oih.2 uc289oih.1 uc289oih.2 
ENSMUST00000220796.3 Gm16596 ENSMUST00000220796.3 Gm16596 (from geneSymbol) AK140072 ENSMUST00000220796.1 ENSMUST00000220796.2 uc007ozu.1 uc007ozu.2 uc007ozu.3 uc007ozu.4 uc007ozu.5 uc007ozu.1 uc007ozu.2 uc007ozu.3 uc007ozu.4 uc007ozu.5 
ENSMUST00000220802.2 Gm40655 ENSMUST00000220802.2 Gm40655 (from geneSymbol) ENSMUST00000220802.1 uc288kiu.1 uc288kiu.2 uc288kiu.1 uc288kiu.2 
ENSMUST00000220806.2 Gm47586 ENSMUST00000220806.2 Gm47586 (from geneSymbol) AK134949 ENSMUST00000220806.1 uc288nsa.1 uc288nsa.2 uc288nsa.1 uc288nsa.2 
ENSMUST00000220812.2 Gm48382 ENSMUST00000220812.2 Gm48382 (from geneSymbol) ENSMUST00000220812.1 uc288iqf.1 uc288iqf.2 uc288iqf.1 uc288iqf.2 
ENSMUST00000220813.2 Gm48682 ENSMUST00000220813.2 Gm48682 (from geneSymbol) AK148250 ENSMUST00000220813.1 uc288kvd.1 uc288kvd.2 uc288kvd.1 uc288kvd.2 
ENSMUST00000220816.2 Esyt2 ENSMUST00000220816.2 Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP- 2 complex (By similarity). Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (By similarity). (from UniProt Q3TZZ7) AK044360 B2RSN5 D12Ertd551e ENSMUST00000220816.1 ESYT2_MOUSE Fam62b Q3TZZ7 Q9D5Y7 uc288keg.1 uc288keg.2 Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP- 2 complex (By similarity). Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (By similarity). Homodimer. Interacts with ESYT1 and ESYT3. Interacts with FGFR1 that has been activated by FGF1 binding. Interacts with the AP-2 complex; identified in a complex with the AP-2 complex and FGFR1 (By similarity). Cell membrane ; Peripheral membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Recruited to the cell membrane via the third C2 domain (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TZZ7-1; Sequence=Displayed; Name=2; IsoId=Q3TZZ7-2; Sequence=VSP_023243; Anchored to the endoplasmic reticulum membrane by a transmembrane hairpin structure; both N-terminus and C-terminus are cytoplasmic. The C2 domains mediate lipid and calcium binding. The N- terminal C2 domain binds calcium ions and is important for calcium- dependent lipid binding and interaction with membranes. Two calcium ions are bound at a high-affinity site and a third calcium ion is bound with lower affinity. May bind up to four calcium ions. In contrast, the second C2 domain apparently does not bind calcium. The third C2 domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate and is required for location at the cell membrane (By similarity). The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior; can bind two lipid molecules simultaneously. Binds a variety of lipids, including phosphatidylethanolamine, phosphatidylcholine and phosphatidylinositol (By similarity). Belongs to the extended synaptotagmin family. calcium ion binding calcium-dependent phospholipid binding endoplasmic reticulum endoplasmic reticulum membrane plasma membrane integral component of plasma membrane lipid transport endocytosis lipid binding phosphatidylethanolamine binding membrane integral component of membrane phosphatidylcholine binding intrinsic component of endoplasmic reticulum membrane extrinsic component of cytoplasmic side of plasma membrane phosphatidylinositol binding identical protein binding organelle membrane contact site metal ion binding endoplasmic reticulum-plasma membrane tethering uc288keg.1 uc288keg.2 
ENSMUST00000220829.2 Gm48309 ENSMUST00000220829.2 Gm48309 (from geneSymbol) AB350766 ENSMUST00000220829.1 uc288ezc.1 uc288ezc.2 uc288ezc.1 uc288ezc.2 
ENSMUST00000220833.3 Gm36377 ENSMUST00000220833.3 Gm36377 (from geneSymbol) ENSMUST00000220833.1 ENSMUST00000220833.2 uc288ojv.1 uc288ojv.2 uc288ojv.3 uc288ojv.1 uc288ojv.2 uc288ojv.3 
ENSMUST00000220843.2 Gm47453 ENSMUST00000220843.2 Gm47453 (from geneSymbol) ENSMUST00000220843.1 uc288gvf.1 uc288gvf.2 uc288gvf.1 uc288gvf.2 
ENSMUST00000220851.2 Gm47447 ENSMUST00000220851.2 Gm47447 (from geneSymbol) AK078718 ENSMUST00000220851.1 uc288htx.1 uc288htx.2 uc288htx.1 uc288htx.2 
ENSMUST00000220862.2 Gm48713 ENSMUST00000220862.2 Gm48713 (from geneSymbol) AK140662 ENSMUST00000220862.1 uc288fzq.1 uc288fzq.2 uc288fzq.1 uc288fzq.2 
ENSMUST00000220865.2 D230049E03Rik ENSMUST00000220865.2 D230049E03Rik (from geneSymbol) ENSMUST00000220865.1 uc288imv.1 uc288imv.2 uc288imv.1 uc288imv.2 
ENSMUST00000220866.2 Gm48296 ENSMUST00000220866.2 Gm48296 (from geneSymbol) ENSMUST00000220866.1 uc288ips.1 uc288ips.2 uc288ips.1 uc288ips.2 
ENSMUST00000220867.2 Gm47456 ENSMUST00000220867.2 Gm47456 (from geneSymbol) ENSMUST00000220867.1 uc288gvi.1 uc288gvi.2 uc288gvi.1 uc288gvi.2 
ENSMUST00000220869.2 Gm47868 ENSMUST00000220869.2 Gm47868 (from geneSymbol) ENSMUST00000220869.1 uc288gbb.1 uc288gbb.2 uc288gbb.1 uc288gbb.2 
ENSMUST00000220871.2 ENSMUSG00000121730 ENSMUST00000220871.2 ENSMUSG00000121730 (from geneSymbol) ENSMUST00000220871.1 uc288non.1 uc288non.2 uc288non.1 uc288non.2 
ENSMUST00000220872.3 Gm48626 ENSMUST00000220872.3 Gm48626 (from geneSymbol) ENSMUST00000220872.1 ENSMUST00000220872.2 uc288lyq.1 uc288lyq.2 uc288lyq.3 uc288lyq.1 uc288lyq.2 uc288lyq.3 
ENSMUST00000220876.3 Gm48819 ENSMUST00000220876.3 Gm48819 (from geneSymbol) AK132978 ENSMUST00000220876.1 ENSMUST00000220876.2 uc288oiv.1 uc288oiv.2 uc288oiv.3 uc288oiv.1 uc288oiv.2 uc288oiv.3 
ENSMUST00000220880.2 Gm48904 ENSMUST00000220880.2 Gm48904 (from geneSymbol) ENSMUST00000220880.1 uc288fqu.1 uc288fqu.2 uc288fqu.1 uc288fqu.2 
ENSMUST00000220881.2 Gm48419 ENSMUST00000220881.2 Gm48419 (from geneSymbol) AK139503 ENSMUST00000220881.1 uc007rbv.1 uc007rbv.2 uc007rbv.3 uc007rbv.1 uc007rbv.2 uc007rbv.3 
ENSMUST00000220886.2 Gm48228 ENSMUST00000220886.2 Gm48228 (from geneSymbol) ENSMUST00000220886.1 uc288nok.1 uc288nok.2 uc288nok.1 uc288nok.2 
ENSMUST00000220893.3 Gm4166 ENSMUST00000220893.3 Gm4166 (from geneSymbol) AK086628 ENSMUST00000220893.1 ENSMUST00000220893.2 uc288fpm.1 uc288fpm.2 uc288fpm.3 uc288fpm.1 uc288fpm.2 uc288fpm.3 
ENSMUST00000220896.2 Gm5784 ENSMUST00000220896.2 Gm5784 (from geneSymbol) AK149188 ENSMUST00000220896.1 uc007ndc.1 uc007ndc.2 uc007ndc.1 uc007ndc.2 
ENSMUST00000220899.2 Cdca4 ENSMUST00000220899.2 cell division cycle associated 4, transcript variant 2 (from RefSeq NM_001359234.1) CDCA4_MOUSE ENSMUST00000220899.1 Hepp NM_001359234 Q3U1C0 Q921E8 Q99MP6 Q9CWM2 uc007pfj.1 uc007pfj.2 uc007pfj.3 uc007pfj.4 May participate in the regulation of cell proliferation through the E2F/RB pathway (By similarity). May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation. Nucleus Expressed preferentially in hematopoietic progenitors and mature blood cells. Expressed at low levels in the heart, lung, spleen, and thymus and at a higher level in muscle. Developmentally regulated. Preferential expression in both fetal and adult hematopoietic progenitors and mature blood cells during embryonic and adult hematopoiesis. Sequence=AAH12953.1; Type=Erroneous initiation; Evidence=; molecular_function nucleus nucleoplasm cytosol plasma membrane biological_process uc007pfj.1 uc007pfj.2 uc007pfj.3 uc007pfj.4 
ENSMUST00000220902.2 Gm47188 ENSMUST00000220902.2 Gm47188 (from geneSymbol) ENSMUST00000220902.1 uc288jfy.1 uc288jfy.2 uc288jfy.1 uc288jfy.2 
ENSMUST00000220905.2 Gm48237 ENSMUST00000220905.2 Gm48237 (from geneSymbol) BC027087 ENSMUST00000220905.1 uc288fxr.1 uc288fxr.2 uc288fxr.1 uc288fxr.2 
ENSMUST00000220908.2 8430406P12Rik ENSMUST00000220908.2 8430406P12Rik (from geneSymbol) ENSMUST00000220908.1 LF199406 uc288kzx.1 uc288kzx.2 uc288kzx.1 uc288kzx.2 
ENSMUST00000220915.2 Gm47905 ENSMUST00000220915.2 Gm47905 (from geneSymbol) ENSMUST00000220915.1 uc288kjj.1 uc288kjj.2 uc288kjj.1 uc288kjj.2 
ENSMUST00000220916.2 Dmac2l ENSMUST00000220916.2 distal membrane arm assembly component 2 like, transcript variant 3 (from RefSeq NM_001361691.1) ATP5S_MOUSE Atp5s Atpw ENSMUST00000220916.1 NM_001361691 Q8R2M3 Q9CRA7 uc007nss.1 uc007nss.2 uc007nss.3 Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway. Homotetramer. Associates with ATP synthase. Mitochondrion Mitochondrion inner membrane Belongs to the ATP synthase subunit s family. mitochondrion mitochondrial inner membrane ATP biosynthetic process ion transport membrane proton-transporting ATP synthase complex, coupling factor F(o) metal ion binding uc007nss.1 uc007nss.2 uc007nss.3 
ENSMUST00000220923.2 Gm48420 ENSMUST00000220923.2 Gm48420 (from geneSymbol) ENSMUST00000220923.1 uc288pfz.1 uc288pfz.2 uc288pfz.1 uc288pfz.2 
ENSMUST00000220930.2 Gm48375 ENSMUST00000220930.2 Gm48375 (from geneSymbol) ENSMUST00000220930.1 LF199374 uc288knj.1 uc288knj.2 uc288knj.1 uc288knj.2 
ENSMUST00000220943.2 Gm48328 ENSMUST00000220943.2 Gm48328 (from geneSymbol) AK142845 ENSMUST00000220943.1 uc288gqt.1 uc288gqt.2 uc288gqt.1 uc288gqt.2 
ENSMUST00000220950.2 Gm47457 ENSMUST00000220950.2 Gm47457 (from geneSymbol) AB352034 ENSMUST00000220950.1 uc288gvj.1 uc288gvj.2 uc288gvj.1 uc288gvj.2 
ENSMUST00000220956.2 Gm47375 ENSMUST00000220956.2 Gm47375 (from geneSymbol) ENSMUST00000220956.1 uc288gci.1 uc288gci.2 uc288gci.1 uc288gci.2 
ENSMUST00000220958.2 Gm47584 ENSMUST00000220958.2 Gm47584 (from geneSymbol) AK148734 ENSMUST00000220958.1 uc288nri.1 uc288nri.2 uc288nri.1 uc288nri.2 
ENSMUST00000220969.2 Gm48209 ENSMUST00000220969.2 Gm48209 (from geneSymbol) ENSMUST00000220969.1 uc288eyu.1 uc288eyu.2 uc288eyu.1 uc288eyu.2 
ENSMUST00000220971.2 Gm48286 ENSMUST00000220971.2 Gm48286 (from geneSymbol) ENSMUST00000220971.1 uc288jkt.1 uc288jkt.2 uc288jkt.1 uc288jkt.2 
ENSMUST00000220987.2 Gm47167 ENSMUST00000220987.2 Gm47167 (from geneSymbol) ENSMUST00000220987.1 uc288iui.1 uc288iui.2 uc288iui.1 uc288iui.2 
ENSMUST00000220999.2 Gm47657 ENSMUST00000220999.2 Gm47657 (from geneSymbol) AK137910 ENSMUST00000220999.1 uc288ldl.1 uc288ldl.2 uc288ldl.1 uc288ldl.2 
ENSMUST00000221020.2 Gm47371 ENSMUST00000221020.2 Gm47371 (from geneSymbol) ENSMUST00000221020.1 uc288gcq.1 uc288gcq.2 uc288gcq.1 uc288gcq.2 
ENSMUST00000221025.2 Crhbp ENSMUST00000221025.2 corticotropin releasing hormone binding protein (from RefSeq NM_198408.3) CRHBP_MOUSE ENSMUST00000221025.1 NM_198408 Q60571 uc007rmk.1 uc007rmk.2 uc007rmk.3 uc007rmk.4 Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Secreted Belongs to the CRF-binding protein family. synaptic transmission, dopaminergic maternal aggressive behavior extracellular region extracellular space nucleus secondary lysosome multivesicular body microtubule inflammatory response female pregnancy hormone-mediated signaling pathway secretory granule dendrite dense core granule cellular response to drug cellular response to potassium ion cellular response to immobilization stress peptide binding hormone metabolic process varicosity perikaryon axon terminus regulated exocytosis behavioral response to ethanol corticotropin-releasing hormone binding regulation of corticotropin secretion negative regulation of corticotropin secretion cellular response to calcium ion cellular response to cocaine cellular response to cAMP cellular response to tumor necrosis factor cellular response to estrogen stimulus cellular response to estradiol stimulus regulation of cellular response to stress cellular response to gonadotropin-releasing hormone negative regulation of corticotropin-releasing hormone receptor activity regulation of N-methyl-D-aspartate selective glutamate receptor activity endoplasmic reticulum Golgi apparatus uc007rmk.1 uc007rmk.2 uc007rmk.3 uc007rmk.4 
ENSMUST00000221027.2 Gm48889 ENSMUST00000221027.2 Gm48889 (from geneSymbol) AK158502 ENSMUST00000221027.1 uc288kpd.1 uc288kpd.2 uc288kpd.1 uc288kpd.2 
ENSMUST00000221031.2 Gm48825 ENSMUST00000221031.2 Gm48825 (from geneSymbol) ENSMUST00000221031.1 uc288kov.1 uc288kov.2 uc288kov.1 uc288kov.2 
ENSMUST00000221038.2 Gm48615 ENSMUST00000221038.2 Gm48615 (from geneSymbol) ENSMUST00000221038.1 uc288mxc.1 uc288mxc.2 uc288mxc.1 uc288mxc.2 
ENSMUST00000221040.2 Gm48795 ENSMUST00000221040.2 Gm48795 (from geneSymbol) ENSMUST00000221040.1 uc288nrc.1 uc288nrc.2 uc288nrc.1 uc288nrc.2 
ENSMUST00000221043.2 Gm48764 ENSMUST00000221043.2 Gm48764 (from geneSymbol) ENSMUST00000221043.1 uc288evn.1 uc288evn.2 uc288evn.1 uc288evn.2 
ENSMUST00000221052.2 Gm48259 ENSMUST00000221052.2 Gm48259 (from geneSymbol) AK046105 ENSMUST00000221052.1 uc288kmz.1 uc288kmz.2 uc288kmz.1 uc288kmz.2 
ENSMUST00000221064.3 Gm48607 ENSMUST00000221064.3 Gm48607 (from geneSymbol) AK086030 ENSMUST00000221064.1 ENSMUST00000221064.2 uc288fbe.1 uc288fbe.2 uc288fbe.3 uc288fbe.1 uc288fbe.2 uc288fbe.3 
ENSMUST00000221068.3 Gm48287 ENSMUST00000221068.3 Gm48287 (from geneSymbol) AK079595 ENSMUST00000221068.1 ENSMUST00000221068.2 uc007rlw.1 uc007rlw.2 uc007rlw.3 uc007rlw.1 uc007rlw.2 uc007rlw.3 
ENSMUST00000221075.2 Gm47486 ENSMUST00000221075.2 Gm47486 (from geneSymbol) ENSMUST00000221075.1 uc288krf.1 uc288krf.2 uc288krf.1 uc288krf.2 
ENSMUST00000221105.2 Gm48632 ENSMUST00000221105.2 Gm48632 (from geneSymbol) ENSMUST00000221105.1 LF234987 uc288jis.1 uc288jis.2 uc288jis.1 uc288jis.2 
ENSMUST00000221111.2 Gm48027 ENSMUST00000221111.2 Gm48027 (from geneSymbol) ENSMUST00000221111.1 uc056ysy.1 uc056ysy.2 uc056ysy.1 uc056ysy.2 
ENSMUST00000221117.2 Gm48573 ENSMUST00000221117.2 Gm48573 (from geneSymbol) ENSMUST00000221117.1 uc288hwc.1 uc288hwc.2 uc288hwc.1 uc288hwc.2 
ENSMUST00000221123.2 Gm47684 ENSMUST00000221123.2 Gm47684 (from geneSymbol) ENSMUST00000221123.1 uc288iid.1 uc288iid.2 uc288iid.1 uc288iid.2 
ENSMUST00000221126.2 Gm47460 ENSMUST00000221126.2 Gm47460 (from geneSymbol) ENSMUST00000221126.1 uc288mnl.1 uc288mnl.2 uc288mnl.1 uc288mnl.2 
ENSMUST00000221127.2 Gm48715 ENSMUST00000221127.2 Gm48715 (from geneSymbol) ENSMUST00000221127.1 uc288fzt.1 uc288fzt.2 uc288fzt.1 uc288fzt.2 
ENSMUST00000221128.2 9630002D21Rik ENSMUST00000221128.2 9630002D21Rik (from geneSymbol) AK082302 ENSMUST00000221128.1 uc288hbp.1 uc288hbp.2 uc288hbp.1 uc288hbp.2 
ENSMUST00000221129.2 Atp6v1c2 ENSMUST00000221129.2 Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). (from UniProt Q99L60) AB088357 Atp6c2 ENSMUST00000221129.1 Q6PHA4 Q99L60 VATC2_MOUSE uc288fdc.1 uc288fdc.2 Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=C2-a; IsoId=Q99L60-1; Sequence=Displayed; Name=2; IsoId=Q99L60-2; Sequence=VSP_024884; Name=3; Synonyms=C2-b; IsoId=Q99L60-3; Sequence=VSP_024885; Predominantly expressed in the lung and kidney. Isoform 1 is lung-specific while isoform 3 is a kidney-specific isoform. Isoform 1 is localized in the lamellar bodies of type II alveolar cells. Isoform 2 is strongly expressed in the cortical and medulla collecting ducts and is found in the plasma membranes of renal alpha and beta intercalated cells. Significant expression seen at 17 dpc and not earlier. Belongs to the V-ATPase C subunit family. vacuolar proton-transporting V-type ATPase, V1 domain ion transport hydrogen-exporting ATPase activity, phosphorylative mechanism hydrogen ion transmembrane transporter activity positive regulation of Wnt signaling pathway proton-transporting V-type ATPase, V1 domain proton-transporting ATPase activity, rotational mechanism protein dimerization activity hydrogen ion transmembrane transport uc288fdc.1 uc288fdc.2 
ENSMUST00000221136.2 Kif28 ENSMUST00000221136.2 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (from UniProt A0A1Y7VM29) A0A1Y7VM29 A0A1Y7VM29_MOUSE ENSMUST00000221136.1 Kif28 uc287oig.1 uc287oig.2 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding motor activity microtubule motor activity ATP binding mitochondrion organization microtubule-based movement microtubule binding mitochondrial membrane organelle transport along microtubule uc287oig.1 uc287oig.2 
ENSMUST00000221143.3 B930059L03Rik ENSMUST00000221143.3 B930059L03Rik (from geneSymbol) AK047421 ENSMUST00000221143.1 ENSMUST00000221143.2 uc011yut.1 uc011yut.2 uc011yut.3 uc011yut.4 uc011yut.1 uc011yut.2 uc011yut.3 uc011yut.4 
ENSMUST00000221152.2 Gm36635 ENSMUST00000221152.2 Gm36635 (from geneSymbol) ENSMUST00000221152.1 uc288jld.1 uc288jld.2 uc288jld.1 uc288jld.2 
ENSMUST00000221155.2 Lrrc72 ENSMUST00000221155.2 leucine rich repeat containing 72, transcript variant 3 (from RefSeq NM_001361098.1) A0A1Y7VMI0 A0A1Y7VMI0_MOUSE ENSMUST00000221155.1 Lrrc72 NM_001361098 uc288fyp.1 uc288fyp.2 molecular_function cellular_component biological_process uc288fyp.1 uc288fyp.2 
ENSMUST00000221163.2 Gm48073 ENSMUST00000221163.2 Gm48073 (from geneSymbol) AK144576 ENSMUST00000221163.1 uc288luc.1 uc288luc.2 uc288luc.1 uc288luc.2 
ENSMUST00000221167.2 Ccnk ENSMUST00000221167.2 cyclin K, transcript variant 4 (from RefSeq NM_009832.3) Ccnk ENSMUST00000221167.1 NM_009832 Q3U3M5 Q3U3M5_MOUSE uc011yrr.1 uc011yrr.2 uc011yrr.3 Belongs to the cyclin family. cyclin K-CDK12 complex cyclin K-CDK13 complex cyclin-dependent protein serine/threonine kinase activity nucleus nucleoplasm protein phosphorylation cellular response to DNA damage stimulus RNA polymerase II carboxy-terminal domain kinase activity protein kinase binding negative regulation by host of viral genome replication negative regulation of cell cycle arrest positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues uc011yrr.1 uc011yrr.2 uc011yrr.3 
ENSMUST00000221170.2 Omd ENSMUST00000221170.2 osteomodulin, transcript variant 1 (from RefSeq NM_012050.3) ENSMUST00000221170.1 NM_012050 O35103 OMD_MOUSE uc007qjp.1 uc007qjp.2 uc007qjp.3 May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin. Binds the alpha(V)beta(3)-integrin. Secreted, extracellular space, extracellular matrix Bone specific. Glycosylated; contains keratan sulfate. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. extracellular region cell adhesion regulation of bone mineralization extracellular matrix uc007qjp.1 uc007qjp.2 uc007qjp.3 
ENSMUST00000221183.2 Gm48829 ENSMUST00000221183.2 Gm48829 (from geneSymbol) ENSMUST00000221183.1 uc288lay.1 uc288lay.2 uc288lay.1 uc288lay.2 
ENSMUST00000221186.3 Gm48479 ENSMUST00000221186.3 Gm48479 (from geneSymbol) ENSMUST00000221186.1 ENSMUST00000221186.2 uc288ezr.1 uc288ezr.2 uc288ezr.3 uc288ezr.1 uc288ezr.2 uc288ezr.3 
ENSMUST00000221188.2 Gm48700 ENSMUST00000221188.2 Gm48700 (from geneSymbol) ENSMUST00000221188.1 uc288iib.1 uc288iib.2 uc288iib.1 uc288iib.2 
ENSMUST00000221195.2 Gm35890 ENSMUST00000221195.2 Gm35890 (from geneSymbol) ENSMUST00000221195.1 uc288ezl.1 uc288ezl.2 uc288ezl.1 uc288ezl.2 
ENSMUST00000221204.2 Gm47494 ENSMUST00000221204.2 Gm47494 (from geneSymbol) AK085808 ENSMUST00000221204.1 uc288kru.1 uc288kru.2 uc288kru.1 uc288kru.2 
ENSMUST00000221214.3 1700030L22Rik ENSMUST00000221214.3 1700030L22Rik (from geneSymbol) AK006560 ENSMUST00000221214.1 ENSMUST00000221214.2 uc288gif.1 uc288gif.2 uc288gif.3 uc288gif.1 uc288gif.2 uc288gif.3 
ENSMUST00000221222.3 Gm32089 ENSMUST00000221222.3 predicted gene, 32089, transcript variant 1 (from RefSeq NR_188762.1) ENSMUST00000221222.1 ENSMUST00000221222.2 NR_188762 uc007rlu.1 uc007rlu.2 uc007rlu.3 uc007rlu.1 uc007rlu.2 uc007rlu.3 
ENSMUST00000221224.3 Gm33016 ENSMUST00000221224.3 Gm33016 (from geneSymbol) ENSMUST00000221224.1 ENSMUST00000221224.2 uc288hbn.1 uc288hbn.2 uc288hbn.3 uc288hbn.1 uc288hbn.2 uc288hbn.3 
ENSMUST00000221227.2 Ndufb1 ENSMUST00000221227.2 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (from UniProt P0DN34) ENSMUST00000221227.1 KY467417 NDUB1_MOUSE P0DN34 uc288itf.1 uc288itf.2 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I is composed of 45 different subunits. Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side Belongs to the complex I NDUFB1 subunit family. NADH dehydrogenase activity mitochondrion mitochondrial inner membrane mitochondrial respiratory chain complex I membrane integral component of membrane mitochondrial respiratory chain complex I assembly oxidation-reduction process respiratory chain uc288itf.1 uc288itf.2 
ENSMUST00000221229.3 Gm49366 ENSMUST00000221229.3 Belongs to the C/M/P thioester hydrolase family. (from UniProt A0A1Y7VML8) A0A1Y7VML8 A0A1Y7VML8_MOUSE BC138741 ENSMUST00000221229.1 ENSMUST00000221229.2 Gm49366 uc288htj.1 uc288htj.2 uc288htj.3 Belongs to the C/M/P thioester hydrolase family. fatty acid metabolic process acyl-CoA metabolic process acyl-CoA hydrolase activity uc288htj.1 uc288htj.2 uc288htj.3 
ENSMUST00000221233.2 Gm47123 ENSMUST00000221233.2 Gm47123 (from geneSymbol) ENSMUST00000221233.1 uc288nvx.1 uc288nvx.2 uc288nvx.1 uc288nvx.2 
ENSMUST00000221235.3 4930549C15Rik ENSMUST00000221235.3 RIKEN cDNA 4930549C15 gene (from RefSeq NR_130981.1) ENSMUST00000221235.1 ENSMUST00000221235.2 NR_130981 uc056ypx.1 uc056ypx.2 uc056ypx.3 uc056ypx.4 uc056ypx.1 uc056ypx.2 uc056ypx.3 uc056ypx.4 
ENSMUST00000221240.2 Kcnk10 ENSMUST00000221240.2 potassium channel, subfamily K, member 10, transcript variant 1 (from RefSeq NM_029911.5) ENSMUST00000221240.1 Kcnk10 NM_029911 Q8BUW1 Q8BUW1_MOUSE uc007oqi.1 uc007oqi.2 uc007oqi.3 uc007oqi.4 Membrane ; Multi- pass membrane protein Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. potassium channel activity plasma membrane integral component of plasma membrane ion transport memory membrane integral component of membrane potassium ion leak channel activity stabilization of membrane potential potassium ion transmembrane transport uc007oqi.1 uc007oqi.2 uc007oqi.3 uc007oqi.4 
ENSMUST00000221249.2 Gm48783 ENSMUST00000221249.2 Gm48783 (from geneSymbol) AK135638 ENSMUST00000221249.1 uc288kvf.1 uc288kvf.2 uc288kvf.1 uc288kvf.2 
ENSMUST00000221260.2 Gm48701 ENSMUST00000221260.2 Gm48701 (from geneSymbol) ENSMUST00000221260.1 uc288nps.1 uc288nps.2 uc288nps.1 uc288nps.2 
ENSMUST00000221266.2 Krbox5 ENSMUST00000221266.2 KRAB box domain containing 5, transcript variant 2 (from RefSeq NM_001309374.1) A0A1Y7VMN9 A0A1Y7VMN9_MOUSE ENSMUST00000221266.1 Gm10037 Krbox5 NM_001309374 uc007rbs.1 uc007rbs.2 uc007rbs.3 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process uc007rbs.1 uc007rbs.2 uc007rbs.3 
ENSMUST00000221276.2 ENSMUSG00000121453 ENSMUST00000221276.2 ENSMUSG00000121453 (from geneSymbol) ENSMUST00000221276.1 uc288nzw.1 uc288nzw.2 uc288nzw.1 uc288nzw.2 
ENSMUST00000221281.3 4930518P08Rik ENSMUST00000221281.3 RIKEN cDNA 4930518P08 gene (from RefSeq NR_045364.1) ENSMUST00000221281.1 ENSMUST00000221281.2 NR_045364 uc029sax.1 uc029sax.2 uc029sax.3 uc029sax.4 uc029sax.1 uc029sax.2 uc029sax.3 uc029sax.4 
ENSMUST00000221298.2 A930027P06Rik ENSMUST00000221298.2 A930027P06Rik (from geneSymbol) AK044624 ENSMUST00000221298.1 uc288lai.1 uc288lai.2 uc288lai.1 uc288lai.2 
ENSMUST00000221302.2 Gm47346 ENSMUST00000221302.2 Gm47346 (from geneSymbol) ENSMUST00000221302.1 uc288ima.1 uc288ima.2 uc288ima.1 uc288ima.2 
ENSMUST00000221310.2 Gm47904 ENSMUST00000221310.2 Gm47904 (from geneSymbol) ENSMUST00000221310.1 uc288kji.1 uc288kji.2 uc288kji.1 uc288kji.2 
ENSMUST00000221311.2 Dbpht2 ENSMUST00000221311.2 Dbpht2 (from geneSymbol) AK158661 ENSMUST00000221311.1 uc007nwy.1 uc007nwy.2 uc007nwy.3 uc007nwy.1 uc007nwy.2 uc007nwy.3 
ENSMUST00000221315.2 Gm40932 ENSMUST00000221315.2 Gm40932 (from geneSymbol) AK033041 ENSMUST00000221315.1 uc007qgy.1 uc007qgy.2 uc007qgy.3 uc007qgy.1 uc007qgy.2 uc007qgy.3 
ENSMUST00000221321.3 Gm40394 ENSMUST00000221321.3 Gm40394 (from geneSymbol) ENSMUST00000221321.1 ENSMUST00000221321.2 uc288fyy.1 uc288fyy.2 uc288fyy.3 uc288fyy.1 uc288fyy.2 uc288fyy.3 
ENSMUST00000221347.2 Gm7969 ENSMUST00000221347.2 Gm7969 (from geneSymbol) AK139503 ENSMUST00000221347.1 uc007rbu.1 uc007rbu.2 uc007rbu.3 uc007rbu.1 uc007rbu.2 uc007rbu.3 
ENSMUST00000221358.2 Gm47260 ENSMUST00000221358.2 Gm47260 (from geneSymbol) AK048792 ENSMUST00000221358.1 uc288ivk.1 uc288ivk.2 uc288ivk.1 uc288ivk.2 
ENSMUST00000221361.2 Gm48264 ENSMUST00000221361.2 Gm48264 (from geneSymbol) ENSMUST00000221361.1 uc288fxt.1 uc288fxt.2 uc288fxt.1 uc288fxt.2 
ENSMUST00000221365.2 Gm47258 ENSMUST00000221365.2 Gm47258 (from geneSymbol) ENSMUST00000221365.1 uc288nyi.1 uc288nyi.2 uc288nyi.1 uc288nyi.2 
ENSMUST00000221366.2 Gm47076 ENSMUST00000221366.2 Gm47076 (from geneSymbol) AK153785 ENSMUST00000221366.1 uc288lwu.1 uc288lwu.2 uc288lwu.1 uc288lwu.2 
ENSMUST00000221371.2 Gm47109 ENSMUST00000221371.2 Gm47109 (from geneSymbol) ENSMUST00000221371.1 uc288ins.1 uc288ins.2 uc288ins.1 uc288ins.2 
ENSMUST00000221385.2 Gm48492 ENSMUST00000221385.2 Gm48492 (from geneSymbol) ENSMUST00000221385.1 uc288kzb.1 uc288kzb.2 uc288kzb.1 uc288kzb.2 
ENSMUST00000221389.2 Gm46430 ENSMUST00000221389.2 Gm46430 (from geneSymbol) ENSMUST00000221389.1 uc288opj.1 uc288opj.2 uc288opj.1 uc288opj.2 
ENSMUST00000221392.2 ENSMUSG00000121692 ENSMUST00000221392.2 ENSMUSG00000121692 (from geneSymbol) ENSMUST00000221392.1 uc288gba.1 uc288gba.2 uc288gba.1 uc288gba.2 
ENSMUST00000221397.2 Nudt14 ENSMUST00000221397.2 nudix hydrolase 14, transcript variant 1 (from RefSeq NM_025399.4) ENSMUST00000221397.1 NM_025399 NUD14_MOUSE Q9CSD2 Q9D142 uc007pfm.1 uc007pfm.2 uc007pfm.3 uc007pfm.4 Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP- glucose, CDP-glucose, GDP-glucose and GDP-mannose (By similarity). Reaction=UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.; EC=3.6.1.45; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Homodimer. Cytoplasm Belongs to the Nudix hydrolase family. cytoplasm nucleoside phosphate metabolic process UDP-sugar diphosphatase activity hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ribose phosphate metabolic process identical protein binding metal ion binding ADP-ribose diphosphatase activity uc007pfm.1 uc007pfm.2 uc007pfm.3 uc007pfm.4 
ENSMUST00000221403.2 Gm47487 ENSMUST00000221403.2 Gm47487 (from geneSymbol) ENSMUST00000221403.1 uc288kri.1 uc288kri.2 uc288kri.1 uc288kri.2 
ENSMUST00000221404.2 Gm3772 ENSMUST00000221404.2 predicted gene 3772 (from RefSeq NR_131156.1) ENSMUST00000221404.1 NR_131156 uc056yud.1 uc056yud.2 uc056yud.1 uc056yud.2 
ENSMUST00000221416.2 Gm48883 ENSMUST00000221416.2 Gm48883 (from geneSymbol) AK081739 ENSMUST00000221416.1 uc288ltu.1 uc288ltu.2 uc288ltu.1 uc288ltu.2 
ENSMUST00000221418.2 Gm48257 ENSMUST00000221418.2 Gm48257 (from geneSymbol) ENSMUST00000221418.1 uc288kmv.1 uc288kmv.2 uc288kmv.1 uc288kmv.2 
ENSMUST00000221433.2 Gm47118 ENSMUST00000221433.2 Gm47118 (from geneSymbol) ENSMUST00000221433.1 uc288miw.1 uc288miw.2 uc288miw.1 uc288miw.2 
ENSMUST00000221438.2 Gm49654 ENSMUST00000221438.2 Gm49654 (from geneSymbol) BC036387 ENSMUST00000221438.1 uc288hoz.1 uc288hoz.2 uc288hoz.1 uc288hoz.2 
ENSMUST00000221440.2 Gm47216 ENSMUST00000221440.2 Gm47216 (from geneSymbol) ENSMUST00000221440.1 uc288peo.1 uc288peo.2 uc288peo.1 uc288peo.2 
ENSMUST00000221441.2 Gm48187 ENSMUST00000221441.2 Gm48187 (from geneSymbol) ENSMUST00000221441.1 uc288eym.1 uc288eym.2 uc288eym.1 uc288eym.2 
ENSMUST00000221442.3 Eif1ad13 ENSMUST00000221442.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. (from UniProt A0A1Y7VJE9) A0A1Y7VJE9 A0A1Y7VJE9_MOUSE ENSMUST00000221442.1 ENSMUST00000221442.2 Eif1ad13 uc288iei.1 uc288iei.2 uc288iei.3 Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. Belongs to the eIF-1A family. RNA binding translation initiation factor activity translation translational initiation uc288iei.1 uc288iei.2 uc288iei.3 
ENSMUST00000221450.2 Gm47513 ENSMUST00000221450.2 Gm47513 (from geneSymbol) ENSMUST00000221450.1 LF199594 uc288nuy.1 uc288nuy.2 uc288nuy.1 uc288nuy.2 
ENSMUST00000221455.2 Gm47370 ENSMUST00000221455.2 Gm47370 (from geneSymbol) AK046391 ENSMUST00000221455.1 uc288imh.1 uc288imh.2 uc288imh.1 uc288imh.2 
ENSMUST00000221460.2 Gm36723 ENSMUST00000221460.2 Gm36723 (from geneSymbol) AK162998 ENSMUST00000221460.1 uc288foh.1 uc288foh.2 uc288foh.1 uc288foh.2 
ENSMUST00000221474.2 Gm47925 ENSMUST00000221474.2 Gm47925 (from geneSymbol) ENSMUST00000221474.1 uc288kjk.1 uc288kjk.2 uc288kjk.1 uc288kjk.2 
ENSMUST00000221477.2 Gm47656 ENSMUST00000221477.2 Gm47656 (from geneSymbol) AK045448 ENSMUST00000221477.1 uc288ojj.1 uc288ojj.2 uc288ojj.1 uc288ojj.2 
ENSMUST00000221484.2 Gm32036 ENSMUST00000221484.2 Gm32036 (from geneSymbol) AK047083 ENSMUST00000221484.1 uc288ldj.1 uc288ldj.2 uc288ldj.1 uc288ldj.2 
ENSMUST00000221493.3 Gm32635 ENSMUST00000221493.3 predicted gene, 32635 (from RefSeq NR_168018.1) ENSMUST00000221493.1 ENSMUST00000221493.2 NR_168018 uc288izy.1 uc288izy.2 uc288izy.3 uc288izy.1 uc288izy.2 uc288izy.3 
ENSMUST00000221495.2 Gm47373 ENSMUST00000221495.2 Gm47373 (from geneSymbol) ENSMUST00000221495.1 uc288gcm.1 uc288gcm.2 uc288gcm.1 uc288gcm.2 
ENSMUST00000221508.3 Gm48538 ENSMUST00000221508.3 Gm48538 (from geneSymbol) ENSMUST00000221508.1 ENSMUST00000221508.2 uc288fcx.1 uc288fcx.2 uc288fcx.3 uc288fcx.1 uc288fcx.2 uc288fcx.3 
ENSMUST00000221514.2 Gm19605 ENSMUST00000221514.2 Gm19605 (from geneSymbol) ENSMUST00000221514.1 KY467656 uc288jgk.1 uc288jgk.2 uc288jgk.1 uc288jgk.2 
ENSMUST00000221520.2 Gm47603 ENSMUST00000221520.2 Gm47603 (from geneSymbol) ENSMUST00000221520.1 uc288nsb.1 uc288nsb.2 uc288nsb.1 uc288nsb.2 
ENSMUST00000221530.2 9330159N22Rik ENSMUST00000221530.2 9330159N22Rik (from geneSymbol) ENSMUST00000221530.1 uc288kqr.1 uc288kqr.2 uc288kqr.1 uc288kqr.2 
ENSMUST00000221536.2 E2f3 ENSMUST00000221536.2 E2F transcription factor 3, transcript variant 3 (from RefSeq NM_001359994.1) A0A1Y7VML1 A0A1Y7VML1_MOUSE E2f3 ENSMUST00000221536.1 NM_001359994 uc007pyr.1 uc007pyr.2 uc007pyr.3 uc007pyr.4 Nucleus Belongs to the E2F/DP family. DNA binding transcription factor activity, sequence-specific DNA binding nucleus transcription factor complex regulation of transcription, DNA-templated protein dimerization activity uc007pyr.1 uc007pyr.2 uc007pyr.3 uc007pyr.4 
ENSMUST00000221538.2 Gm48358 ENSMUST00000221538.2 Gm48358 (from geneSymbol) ENSMUST00000221538.1 uc288gqy.1 uc288gqy.2 uc288gqy.1 uc288gqy.2 
ENSMUST00000221551.2 Gm48574 ENSMUST00000221551.2 Gm48574 (from geneSymbol) ENSMUST00000221551.1 LF199376 uc288knv.1 uc288knv.2 uc288knv.1 uc288knv.2 
ENSMUST00000221553.2 Gm48327 ENSMUST00000221553.2 Gm48327 (from geneSymbol) ENSMUST00000221553.1 uc288knf.1 uc288knf.2 uc288knf.1 uc288knf.2 
ENSMUST00000221562.2 Gm47979 ENSMUST00000221562.2 Gm47979 (from geneSymbol) ENSMUST00000221562.1 uc288gue.1 uc288gue.2 uc288gue.1 uc288gue.2 
ENSMUST00000221565.2 Gm47322 ENSMUST00000221565.2 Gm47322 (from geneSymbol) AK048816 ENSMUST00000221565.1 uc288ksa.1 uc288ksa.2 uc288ksa.1 uc288ksa.2 
ENSMUST00000221569.3 ENSMUSG00000121353 ENSMUST00000221569.3 ENSMUSG00000121353 (from geneSymbol) ENSMUST00000221569.1 ENSMUST00000221569.2 uc288kjq.1 uc288kjq.2 uc288kjq.3 uc288kjq.1 uc288kjq.2 uc288kjq.3 
ENSMUST00000221571.2 AA414992 ENSMUST00000221571.2 AA414992 (from geneSymbol) AK139612 ENSMUST00000221571.1 uc288ohc.1 uc288ohc.2 uc288ohc.1 uc288ohc.2 
ENSMUST00000221580.2 Gm47004 ENSMUST00000221580.2 Gm47004 (from geneSymbol) ENSMUST00000221580.1 uc288nvo.1 uc288nvo.2 uc288nvo.1 uc288nvo.2 
ENSMUST00000221592.3 Gm48558 ENSMUST00000221592.3 Gm48558 (from geneSymbol) AK144895 ENSMUST00000221592.1 ENSMUST00000221592.2 uc288fav.1 uc288fav.2 uc288fav.3 uc288fav.1 uc288fav.2 uc288fav.3 
ENSMUST00000221602.2 Gm48383 ENSMUST00000221602.2 Gm48383 (from geneSymbol) ENSMUST00000221602.1 uc288iqm.1 uc288iqm.2 uc288iqm.1 uc288iqm.2 
ENSMUST00000221603.2 3200001D21Rik ENSMUST00000221603.2 RIKEN cDNA 3200001D21 gene (from RefSeq NR_045888.2) ENSMUST00000221603.1 NR_045888 uc029rul.1 uc029rul.2 uc029rul.1 uc029rul.2 
ENSMUST00000221626.2 ENSMUSG00000121656 ENSMUST00000221626.2 ENSMUSG00000121656 (from geneSymbol) ENSMUST00000221626.1 LF279729 uc288fpk.1 uc288fpk.2 uc288fpk.1 uc288fpk.2 
ENSMUST00000221638.2 Gm48887 ENSMUST00000221638.2 Gm48887 (from geneSymbol) AK136827 ENSMUST00000221638.1 uc288koy.1 uc288koy.2 uc288koy.1 uc288koy.2 
ENSMUST00000221641.2 Gm48695 ENSMUST00000221641.2 Gm48695 (from geneSymbol) ENSMUST00000221641.1 uc288gzd.1 uc288gzd.2 uc288gzd.1 uc288gzd.2 
ENSMUST00000221643.2 Gm31508 ENSMUST00000221643.2 predicted gene, 31508 (from RefSeq NR_154989.1) ENSMUST00000221643.1 NR_154989 uc288fra.1 uc288fra.2 uc288fra.1 uc288fra.2 
ENSMUST00000221653.2 Gm48585 ENSMUST00000221653.2 Gm48585 (from geneSymbol) AK037395 ENSMUST00000221653.1 uc288iqx.1 uc288iqx.2 uc288iqx.1 uc288iqx.2 
ENSMUST00000221659.2 Nlrp4f ENSMUST00000221659.2 Belongs to the NLRP family. (from UniProt L7N1W9) AY596201 ENSMUST00000221659.1 L7N1W9 L7N1W9_MOUSE Nlrp4f uc007qzh.1 uc007qzh.2 uc007qzh.3 Belongs to the NLRP family. nucleotide binding ATP binding uc007qzh.1 uc007qzh.2 uc007qzh.3 
ENSMUST00000221662.2 A930040O22Rik ENSMUST00000221662.2 A930040O22Rik (from geneSymbol) AK020947 ENSMUST00000221662.1 uc288ink.1 uc288ink.2 uc288ink.1 uc288ink.2 
ENSMUST00000221667.2 Gm48745 ENSMUST00000221667.2 Gm48745 (from geneSymbol) AK155143 ENSMUST00000221667.1 uc288pgr.1 uc288pgr.2 uc288pgr.1 uc288pgr.2 
ENSMUST00000221673.2 Gm47987 ENSMUST00000221673.2 Gm47987 (from geneSymbol) AK042710 ENSMUST00000221673.1 uc288guv.1 uc288guv.2 uc288guv.1 uc288guv.2 
ENSMUST00000221683.2 Gm48754 ENSMUST00000221683.2 Gm48754 (from geneSymbol) ENSMUST00000221683.1 uc288laf.1 uc288laf.2 uc288laf.1 uc288laf.2 
ENSMUST00000221687.2 Gm48422 ENSMUST00000221687.2 Gm48422 (from geneSymbol) ENSMUST00000221687.1 uc288grv.1 uc288grv.2 uc288grv.1 uc288grv.2 
ENSMUST00000221692.2 Gm47210 ENSMUST00000221692.2 Gm47210 (from geneSymbol) AK037155 ENSMUST00000221692.1 uc007rln.1 uc007rln.2 uc007rln.3 uc007rln.1 uc007rln.2 uc007rln.3 
ENSMUST00000221700.2 A730091E23Rik ENSMUST00000221700.2 A730091E23Rik (from geneSymbol) AK043390 ENSMUST00000221700.1 uc288lua.1 uc288lua.2 uc288lua.1 uc288lua.2 
ENSMUST00000221702.2 Gm47454 ENSMUST00000221702.2 Gm47454 (from geneSymbol) AK132903 ENSMUST00000221702.1 uc288gvh.1 uc288gvh.2 uc288gvh.1 uc288gvh.2 
ENSMUST00000221703.2 Slc9a3 ENSMUST00000221703.2 Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:9662405). (from UniProt G3X939) AK033564 ENSMUST00000221703.1 G3X939 Q8BZU0 SL9A3_MOUSE Slc9a3 uc007ret.1 uc007ret.2 uc007ret.3 Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:9662405). Reaction=H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out); Xref=Rhea:RHEA:29419, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101; Evidence=; Seems to switch between active and inactive modes in response to various stimuli (By similarity). Activated directly or indirectly by membrane phosphatidylinositol (PIs) (By similarity). Regulated by a variety of auxiliary proteins, which facilitate the maturation, cell surface expression and function of the transporter. Inhibited specifically by the drug tenapanor (By similarity). Homodimer (By similarity). Found in the forms of complex and dynamic macromolecular complexes (By similarity). Binds NHERF1 and NHERF2 (By similarity). Interacts with CHP1; this interaction increases trafficking and activity of SLC9A3 at the plasma membrane (By similarity). Interacts with CHP2 and SHANK2. Interacts with PDZK1 (via C-terminal PDZ domain) (By similarity). Interacts with NHERF4 and interactions decrease in response to elevated calcium ion levels (By similarity). Interacts with AHCYL1; the interaction is required for SLC9A3 activity (By similarity). Interacts with EZR; interaction targets SLC9A3 to the apical membrane (By similarity). Interacts with SNX27 (via PDZ domains); directs SLC9A3 membrane insertion from early endosomes to the plasma membrane (By similarity). Apical cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Early endosome membrane ; Multi-pass membrane protein Note=In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity). The C-terminal intracellular domain is subject to extensive post-translational modifications and binding partner interactions which regulate transporter activity, scaffolding functions, downstream events and localization. Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-659 by SGK1 is associated with increased abundance at the cell membrane. Phosphorylation at Ser-714 by CSNK2A1 regulates SLC9A3 activity through the formation of multiple signaling complexes (By similarity). Deficient mice have diarrhea associated with proximal tubular acidosis and hypotension. Males are infertile. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. regulation of sodium ion transport plasma membrane brush border ion transport cation transport sodium ion transport regulation of pH receptor-mediated endocytosis antiporter activity solute:proton antiporter activity sodium:proton antiporter activity potassium:proton antiporter activity membrane integral component of membrane apical plasma membrane PDZ domain binding brush border membrane vesicle regulation of intracellular pH transmembrane transport extracellular exosome potassium ion transmembrane transport anion transmembrane transport sodium ion import across plasma membrane hydrogen ion transmembrane transport uc007ret.1 uc007ret.2 uc007ret.3 
ENSMUST00000221705.2 Gm47407 ENSMUST00000221705.2 Gm47407 (from geneSymbol) ENSMUST00000221705.1 uc288kqv.1 uc288kqv.2 uc288kqv.1 uc288kqv.2 
ENSMUST00000221723.3 Gm48812 ENSMUST00000221723.3 Gm48812 (from geneSymbol) ENSMUST00000221723.1 ENSMUST00000221723.2 uc288nrg.1 uc288nrg.2 uc288nrg.3 uc288nrg.1 uc288nrg.2 uc288nrg.3 
ENSMUST00000221728.3 Gm32699 ENSMUST00000221728.3 Gm32699 (from geneSymbol) AK082045 ENSMUST00000221728.1 ENSMUST00000221728.2 uc288lag.1 uc288lag.2 uc288lag.3 uc288lag.1 uc288lag.2 uc288lag.3 
ENSMUST00000221729.2 Gm48872 ENSMUST00000221729.2 Gm48872 (from geneSymbol) ENSMUST00000221729.1 uc288kpf.1 uc288kpf.2 uc288kpf.1 uc288kpf.2 
ENSMUST00000221730.2 Mrpl36 ENSMUST00000221730.2 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. (from UniProt Q99N90) AK160778 ENSMUST00000221730.1 Q3V2T6 Q99N90 RM36_MOUSE uc033gml.1 uc033gml.2 uc033gml.3 Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Mitochondrion Belongs to the bacterial ribosomal protein bL36 family. structural constituent of ribosome mitochondrion mitochondrial large ribosomal subunit ribosome translation nuclear body ribosome biogenesis uc033gml.1 uc033gml.2 uc033gml.3 
ENSMUST00000221736.2 Gm47196 ENSMUST00000221736.2 Gm47196 (from geneSymbol) AK040797 ENSMUST00000221736.1 uc288iop.1 uc288iop.2 uc288iop.1 uc288iop.2 
ENSMUST00000221737.2 Gm35732 ENSMUST00000221737.2 Gm35732 (from geneSymbol) ENSMUST00000221737.1 uc288ltw.1 uc288ltw.2 uc288ltw.1 uc288ltw.2 
ENSMUST00000221738.2 Gm47661 ENSMUST00000221738.2 Gm47661 (from geneSymbol) ENSMUST00000221738.1 uc288lbi.1 uc288lbi.2 uc288lbi.1 uc288lbi.2 
ENSMUST00000221740.2 Cdcp2 ENSMUST00000221740.2 Lacks conserved residue(s) required for the propagation of feature annotation. (from UniProt A0A1Y7VJ18) A0A1Y7VJ18 A0A1Y7VJ18_MOUSE BC146400 Cdcp2 ENSMUST00000221740.1 uc290oij.1 uc290oij.2 Lacks conserved residue(s) required for the propagation of feature annotation. membrane integral component of membrane uc290oij.1 uc290oij.2 
ENSMUST00000221747.2 Zfp935 ENSMUST00000221747.2 zinc finger protein 935, transcript variant 1 (from RefSeq NM_178875.4) 8430426H19Rik ENSMUST00000221747.1 Gm49359 NM_178875 Q14DI0 Q14DI0_MOUSE Zfp935 uc007qwv.1 uc007qwv.2 uc007qwv.3 uc007qwv.4 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc007qwv.1 uc007qwv.2 uc007qwv.3 uc007qwv.4 
ENSMUST00000221759.2 Gm47826 ENSMUST00000221759.2 Gm47826 (from geneSymbol) ENSMUST00000221759.1 uc288kqk.1 uc288kqk.2 uc288kqk.1 uc288kqk.2 
ENSMUST00000221760.2 1700011B04Rik ENSMUST00000221760.2 1700011B04Rik (from geneSymbol) AK005856 ENSMUST00000221760.1 uc288lyw.1 uc288lyw.2 uc288lyw.1 uc288lyw.2 
ENSMUST00000221761.2 Id2 ENSMUST00000221761.2 Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. (from UniProt Q545T4) AK146606 ENSMUST00000221761.1 Id2 Q545T4 Q545T4_MOUSE uc007nfe.1 uc007nfe.2 uc007nfe.3 uc007nfe.4 Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. Cytoplasm Nucleus nucleus cytoplasm cytosol negative regulation of sequence-specific DNA binding transcription factor activity ion channel binding negative regulation of transcription, DNA-templated protein dimerization activity regulation of G1/S transition of mitotic cell cycle uc007nfe.1 uc007nfe.2 uc007nfe.3 uc007nfe.4 
ENSMUST00000221765.2 Gm35161 ENSMUST00000221765.2 Gm35161 (from geneSymbol) ENSMUST00000221765.1 uc288ohy.1 uc288ohy.2 uc288ohy.1 uc288ohy.2 
ENSMUST00000221766.2 Gm47802 ENSMUST00000221766.2 Gm47802 (from geneSymbol) ENSMUST00000221766.1 uc288kqj.1 uc288kqj.2 uc288kqj.1 uc288kqj.2 
ENSMUST00000221767.2 Gm47781 ENSMUST00000221767.2 Gm47781 (from geneSymbol) ENSMUST00000221767.1 uc288mll.1 uc288mll.2 uc288mll.1 uc288mll.2 
ENSMUST00000221776.2 2900042G08Rik ENSMUST00000221776.2 2900042G08Rik (from geneSymbol) AK019333 ENSMUST00000221776.1 uc288klo.1 uc288klo.2 uc288klo.1 uc288klo.2 
ENSMUST00000221778.2 A530046M15Rik ENSMUST00000221778.2 RIKEN cDNA A530046M15 gene (from RefSeq NR_046131.1) ENSMUST00000221778.1 NR_046131 uc007pnt.1 uc007pnt.2 uc007pnt.1 uc007pnt.2 
ENSMUST00000221779.2 5033424D13Rik ENSMUST00000221779.2 5033424D13Rik (from geneSymbol) AK017190 ENSMUST00000221779.1 uc288jch.1 uc288jch.2 uc288jch.1 uc288jch.2 
ENSMUST00000221790.2 Gm48709 ENSMUST00000221790.2 Gm48709 (from geneSymbol) AK145102 ENSMUST00000221790.1 uc288hwv.1 uc288hwv.2 uc288hwv.1 uc288hwv.2 
ENSMUST00000221799.2 Gm47080 ENSMUST00000221799.2 Gm47080 (from geneSymbol) ENSMUST00000221799.1 uc288hpd.1 uc288hpd.2 uc288hpd.1 uc288hpd.2 
ENSMUST00000221802.2 Gm48771 ENSMUST00000221802.2 Gm48771 (from geneSymbol) AK133798 ENSMUST00000221802.1 uc288ire.1 uc288ire.2 uc288ire.1 uc288ire.2 
ENSMUST00000221804.2 Gm47405 ENSMUST00000221804.2 Gm47405 (from geneSymbol) ENSMUST00000221804.1 uc288kqp.1 uc288kqp.2 uc288kqp.1 uc288kqp.2 
ENSMUST00000221807.2 Zbed3 ENSMUST00000221807.2 zinc finger, BED type containing 3, transcript variant 3 (from RefSeq NM_001302539.1) ENSMUST00000221807.1 NM_001302539 Q9D0L1 ZBED3_MOUSE uc007rmg.1 uc007rmg.2 uc007rmg.3 uc007rmg.4 This gene encodes a member of the zinc finger protein superfamily. This protein may regulate the Wnt/beta-catenin signaling pathway. This protein may be involved in insulin resistance and type 2 diabetes in humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin (PubMed:19141611). Involved in transcription activation of Wnt target gene expression (PubMed:19141611). Plays a role in symmetric division of blastomeres in the early stages of embryogenesis via regulation of mitotic spindle central positioning and organization of the F-actin filament network (PubMed:28992324). Plays a role in regulating the distribution of cellular organelles, via modulation of cytoskeletal dynamics and cytoplasmic lattice formation (PubMed:28992324). Associates with the subcortical maternal complex (SCMC) composed of at least NLRP5, KHDC3, OOEP, and TLE6 via interaction with NLRP5 and TLE6 (PubMed:28992324, PubMed:31575650). Interacts (via PPPSP motif) with AXIN1; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B- induced beta-catenin serine and threonine phosphorylations (PubMed:19141611). Cytoplasm mbrane Secreted Note=Colocalizes with AXIN1 in the cytoplasm (PubMed:19141611). Colocalizes with NLRP5 in the oocyte subcortex (PubMed:28992324). Expressed in the liver (at protein level) (PubMed:24283382). Abundantly expressed in muscle, with lower expression in brain, fat, and heart (PubMed:24283382). Expressed in the spleen, lungs and kidney (PubMed:24283382, PubMed:28992324). Abundantly expressed in ovaries and testis, with lower expression in the uterus (PubMed:28992324). Expressed in the cytoplasm of germinal vesicle oocytes before becoming concentrated in the subcortex of metaphase 2 oocytes (PubMed:28992324). Expressed in ovaries at birth, expression peaks at postnatal day 10 (P10), expression is then decreased at P17 and further decreased at P21 (PubMed:31575650). Dual phosphorylation on serine and tyrosine residues of the cytoplasmic PPPSP motif by GSK3 and CK1 may be required for AXIN1- binding. Males show normal fertility however females produce smaller litters (PubMed:28992324). Increase in the number of 2- cell embryos with asymmetric blastomeres as a result of impaired central mitotic spindle position and therefore an increase in the distance between the cellular center and the chromosomes (PubMed:28992324). Disorganization of the F-actin filament network around the mitotic spindle and loss of FMN2-expressing endoplasmic reticulum localization to the mitotic spindle periphery in zygotes and oocytes (PubMed:28992324). Mitochondria are mislocalized to the plus- ends of elongated microtubules in the subcortical cytoplasm in oocytes prior to nuclear envelope breakdown (PubMed:28992324). Loss of cytoplasmic lattices and extension of the alpha-tubulin pool into the subcortical region following microtubule-organizing center congression in oocytes (PubMed:28992324). negative regulation of protein phosphorylation DNA binding protein binding cytoplasm cytosol membrane Wnt signaling pathway positive regulation of transcription from RNA polymerase II promoter metal ion binding protein stabilization positive regulation of canonical Wnt signaling pathway uc007rmg.1 uc007rmg.2 uc007rmg.3 uc007rmg.4 
ENSMUST00000221809.2 Gm47988 ENSMUST00000221809.2 Gm47988 (from geneSymbol) ENSMUST00000221809.1 uc288guo.1 uc288guo.2 uc288guo.1 uc288guo.2 
ENSMUST00000221819.2 Gm35558 ENSMUST00000221819.2 Gm35558 (from geneSymbol) ENSMUST00000221819.1 uc288jgt.1 uc288jgt.2 uc288jgt.1 uc288jgt.2 
ENSMUST00000221830.2 Gm8016 ENSMUST00000221830.2 predicted gene 8016 (from RefSeq NR_152173.1) ENSMUST00000221830.1 NR_152173 uc007rbx.1 uc007rbx.2 uc007rbx.3 uc007rbx.1 uc007rbx.2 uc007rbx.3 
ENSMUST00000221832.2 Gm48221 ENSMUST00000221832.2 Gm48221 (from geneSymbol) ENSMUST00000221832.1 uc288oag.1 uc288oag.2 uc288oag.1 uc288oag.2 
ENSMUST00000221835.2 Gm48374 ENSMUST00000221835.2 Gm48374 (from geneSymbol) AK016837 ENSMUST00000221835.1 uc288knu.1 uc288knu.2 uc288knu.1 uc288knu.2 
ENSMUST00000221845.2 Gm47372 ENSMUST00000221845.2 Gm47372 (from geneSymbol) AK053097 ENSMUST00000221845.1 uc288imi.1 uc288imi.2 uc288imi.1 uc288imi.2 
ENSMUST00000221848.2 A730018C14Rik ENSMUST00000221848.2 RIKEN cDNA A730018C14 gene (from RefSeq NR_036459.1) ENSMUST00000221848.1 NR_036459 uc011yve.1 uc011yve.2 uc011yve.1 uc011yve.2 
ENSMUST00000221849.2 6030440G07Rik ENSMUST00000221849.2 RIKEN cDNA 6030440G07 gene (from RefSeq NR_036598.1) ENSMUST00000221849.1 NR_036598 uc029ryd.1 uc029ryd.2 uc029ryd.3 uc029ryd.1 uc029ryd.2 uc029ryd.3 
ENSMUST00000221851.2 Gm46436 ENSMUST00000221851.2 Gm46436 (from geneSymbol) AK081610 ENSMUST00000221851.1 uc288phu.1 uc288phu.2 uc288phu.1 uc288phu.2 
ENSMUST00000221855.2 Gm47408 ENSMUST00000221855.2 Gm47408 (from geneSymbol) ENSMUST00000221855.1 uc288krd.1 uc288krd.2 uc288krd.1 uc288krd.2 
ENSMUST00000221858.2 Gm47583 ENSMUST00000221858.2 Gm47583 (from geneSymbol) AK137771 ENSMUST00000221858.1 uc288nrr.1 uc288nrr.2 uc288nrr.1 uc288nrr.2 
ENSMUST00000221862.2 Gm35725 ENSMUST00000221862.2 predicted gene, 35725 (from RefSeq NR_136761.1) ENSMUST00000221862.1 NR_136761 uc057kns.1 uc057kns.2 uc057kns.1 uc057kns.2 
ENSMUST00000221877.2 Eipr1 ENSMUST00000221877.2 EARP complex and GARP complex interacting protein 1, transcript variant 1 (from RefSeq NM_201357.3) E9QN80 EIPR1_MOUSE ENSMUST00000221877.1 Eipr1 NM_201357 Q8K0G5 Tssc1 uc007ngb.1 uc007ngb.2 uc007ngb.3 uc007ngb.4 Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (By similarity). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein (By similarity). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (By similarity). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity). Interacts with two multisubunit tethering complexes: EARP composed of VPS50, VPS51, VPS52 and VPS53 subunits and GARP complex composed of VPS51, VPS52, VPS53 and VPS54 subunits. Interacts with SNAP29. Golgi apparatus, trans-Golgi network Belongs to the WD repeat EIPR1 family. molecular_function Golgi apparatus trans-Golgi network protein ubiquitination positive regulation of dense core granule transport positive regulation of retrograde transport, endosome to Golgi positive regulation of endocytic recycling GARP complex EARP complex uc007ngb.1 uc007ngb.2 uc007ngb.3 uc007ngb.4 
ENSMUST00000221882.3 9530014B07Rik ENSMUST00000221882.3 RIKEN cDNA 9530014B07 gene (from RefSeq NR_131079.1) ENSMUST00000221882.1 ENSMUST00000221882.2 NR_131079 uc007qnx.1 uc007qnx.2 uc007qnx.3 uc007qnx.4 uc007qnx.5 uc007qnx.1 uc007qnx.2 uc007qnx.3 uc007qnx.4 uc007qnx.5 
ENSMUST00000221885.3 Gm33467 ENSMUST00000221885.3 Gm33467 (from geneSymbol) ENSMUST00000221885.1 ENSMUST00000221885.2 uc288jbt.1 uc288jbt.2 uc288jbt.3 uc288jbt.1 uc288jbt.2 uc288jbt.3 
ENSMUST00000221886.2 Gm48436 ENSMUST00000221886.2 Gm48436 (from geneSymbol) ENSMUST00000221886.1 uc288ohe.1 uc288ohe.2 uc288ohe.1 uc288ohe.2 
ENSMUST00000221888.2 Gm47139 ENSMUST00000221888.2 Gm47139 (from geneSymbol) AK012244 ENSMUST00000221888.1 uc288iog.1 uc288iog.2 uc288iog.1 uc288iog.2 
ENSMUST00000221891.2 Gm10933 ENSMUST00000221891.2 Gm10933 (from geneSymbol) AK148176 ENSMUST00000221891.1 uc057bba.1 uc057bba.2 uc057bba.3 uc057bba.1 uc057bba.2 uc057bba.3 
ENSMUST00000221900.2 Gm40658 ENSMUST00000221900.2 Gm40658 (from geneSymbol) ENSMUST00000221900.1 uc288kkj.1 uc288kkj.2 uc288kkj.1 uc288kkj.2 
ENSMUST00000221902.2 Gm48062 ENSMUST00000221902.2 Gm48062 (from geneSymbol) AK039385 ENSMUST00000221902.1 uc288ine.1 uc288ine.2 uc288ine.1 uc288ine.2 
ENSMUST00000221909.2 4930423D22Rik ENSMUST00000221909.2 4930423D22Rik (from geneSymbol) AK015187 ENSMUST00000221909.1 uc288hpc.1 uc288hpc.2 uc288hpc.1 uc288hpc.2 
ENSMUST00000221918.3 Gm47548 ENSMUST00000221918.3 Gm47548 (from geneSymbol) ENSMUST00000221918.1 ENSMUST00000221918.2 uc288klj.1 uc288klj.2 uc288klj.3 uc288klj.1 uc288klj.2 uc288klj.3 
ENSMUST00000221919.2 Zfyve1 ENSMUST00000221919.2 zinc finger, FYVE domain containing 1, transcript variant 3 (from RefSeq NM_001359167.1) ENSMUST00000221919.1 NM_001359167 Q3TC20 Q810J8 ZFYV1_MOUSE uc288hrj.1 uc288hrj.2 Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contact sites by forming a complex with RAB18 and ZW10 (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (By similarity). Interacts with RAB18 (in GTP-bound form) (By similarity). Interacts with BSCL2 in a RAB18-dependent manner (By similarity). Interacts with ZW10 (By similarity). Golgi apparatus Golgi apparatus, Golgi stack Endoplasmic reticulum Preautophagosomal structure Lipid droplet Mitochondrion Note=Resides predominantly in the cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum. During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localizes to lipid droplets in the presence of oleic acid (By similarity). Ubiquitous. pre-autophagosomal structure 1-phosphatidylinositol binding phosphatidylinositol-3,4,5-trisphosphate binding autophagosome endoplasmic reticulum Golgi apparatus Golgi stack cellular response to starvation negative regulation of phosphatase activity membrane macroautophagy phosphatidylinositol-3,4-bisphosphate binding ER-mitochondrion membrane contact site metal ion binding perinuclear region of cytoplasm extrinsic component of omegasome membrane omegasome uc288hrj.1 uc288hrj.2 
ENSMUST00000221920.2 Gm5082 ENSMUST00000221920.2 predicted gene 5082 (from RefSeq NR_188112.1) ENSMUST00000221920.1 NR_188112 uc007qfg.1 uc007qfg.2 uc007qfg.3 uc007qfg.4 uc007qfg.5 uc007qfg.1 uc007qfg.2 uc007qfg.3 uc007qfg.4 uc007qfg.5 
ENSMUST00000221927.2 Gm47127 ENSMUST00000221927.2 Gm47127 (from geneSymbol) ENSMUST00000221927.1 uc288lxh.1 uc288lxh.2 uc288lxh.1 uc288lxh.2 
ENSMUST00000221928.2 Gm47989 ENSMUST00000221928.2 Gm47989 (from geneSymbol) ENSMUST00000221928.1 uc288guu.1 uc288guu.2 uc288guu.1 uc288guu.2 
ENSMUST00000221931.3 Gm48548 ENSMUST00000221931.3 Gm48548 (from geneSymbol) AK039269 ENSMUST00000221931.1 ENSMUST00000221931.2 uc007qny.1 uc007qny.2 uc007qny.3 uc007qny.1 uc007qny.2 uc007qny.3 
ENSMUST00000221940.3 Gm47194 ENSMUST00000221940.3 Gm47194 (from geneSymbol) ENSMUST00000221940.1 ENSMUST00000221940.2 uc288nwz.1 uc288nwz.2 uc288nwz.3 uc288nwz.1 uc288nwz.2 uc288nwz.3 
ENSMUST00000221942.2 Gm26512 ENSMUST00000221942.2 Gm26512 (from geneSymbol) AK029834 ENSMUST00000221942.1 uc288iih.1 uc288iih.2 uc288iih.1 uc288iih.2 
ENSMUST00000221947.3 Gm36550 ENSMUST00000221947.3 Gm36550 (from geneSymbol) ENSMUST00000221947.1 ENSMUST00000221947.2 uc288mqr.1 uc288mqr.2 uc288mqr.3 uc288mqr.1 uc288mqr.2 uc288mqr.3 
ENSMUST00000221964.2 Gm47424 ENSMUST00000221964.2 Gm47424 (from geneSymbol) ENSMUST00000221964.1 uc288nui.1 uc288nui.2 uc288nui.1 uc288nui.2 
ENSMUST00000221972.2 Rps6kl1 ENSMUST00000221972.2 ribosomal protein S6 kinase-like 1, transcript variant 2 (from RefSeq NM_146244.4) ENSMUST00000221972.1 NM_146244 Q8R1D4 Q8R2S1 RPKL1_MOUSE uc007ogn.1 uc007ogn.2 uc007ogn.3 uc007ogn.4 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R2S1-1; Sequence=Displayed; Name=2; IsoId=Q8R2S1-2; Sequence=VSP_017935, VSP_017936, VSP_017937, VSP_017938; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding ribosome protein phosphorylation kinase activity phosphorylation transferase activity uc007ogn.1 uc007ogn.2 uc007ogn.3 uc007ogn.4 
ENSMUST00000221978.2 Gm47166 ENSMUST00000221978.2 Gm47166 (from geneSymbol) ENSMUST00000221978.1 uc288iuj.1 uc288iuj.2 uc288iuj.1 uc288iuj.2 
ENSMUST00000221985.2 Gm10811 ENSMUST00000221985.2 Gm10811 (from geneSymbol) AK150079 ENSMUST00000221985.1 uc288kuf.1 uc288kuf.2 uc288kuf.1 uc288kuf.2 
ENSMUST00000221989.2 Gm36264 ENSMUST00000221989.2 Gm36264 (from geneSymbol) ENSMUST00000221989.1 uc288koo.1 uc288koo.2 uc288koo.1 uc288koo.2 
ENSMUST00000221996.2 Platr25 ENSMUST00000221996.2 Belongs to the krueppel C2H2-type zinc-finger protein family. (from UniProt A0A1Y7VIS4) A0A1Y7VIS4 A0A1Y7VIS4_MOUSE ENSMUST00000221996.1 Platr25 uc288nql.1 uc288nql.2 Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding nucleus regulation of transcription, DNA-templated metal ion binding uc288nql.1 uc288nql.2 
ENSMUST00000222001.2 Gm48421 ENSMUST00000222001.2 Gm48421 (from geneSymbol) ENSMUST00000222001.1 uc288gru.1 uc288gru.2 uc288gru.1 uc288gru.2 
ENSMUST00000222007.2 ENSMUSG00000121348 ENSMUST00000222007.2 ENSMUSG00000121348 (from geneSymbol) ENSMUST00000222007.1 uc288kgv.1 uc288kgv.2 uc288kgv.1 uc288kgv.2 
ENSMUST00000222015.2 ENSMUSG00000121707 ENSMUST00000222015.2 ENSMUSG00000121707 (from geneSymbol) ENSMUST00000222015.1 uc288kvz.1 uc288kvz.2 uc288kvz.1 uc288kvz.2 
ENSMUST00000222016.2 Gm48686 ENSMUST00000222016.2 Gm48686 (from geneSymbol) AK089877 ENSMUST00000222016.1 uc288kgm.1 uc288kgm.2 uc288kgm.1 uc288kgm.2 
ENSMUST00000222028.2 Ptpdc1 ENSMUST00000222028.2 protein tyrosine phosphatase domain containing 1, transcript variant 1 (from RefSeq NM_001301781.1) ENSMUST00000222028.1 NM_001301781 PTPC1_MOUSE Q3V0Z6 Q3V3K9 Q3V3Y0 Q6NV81 Q6NZK8 Q8BKD9 uc007qij.1 uc007qij.2 uc007qij.3 uc007qij.4 The protein encoded by this gene is a centrosomal mitotic phosphatase. This protein has been implicated in centrosomal duplication and cytokinesis. In addition, knockdown of expression levels in non-cycling cells results in extra long cilia, suggesting that this protein may function in regulating cilia length independent of a function in cell cycle control. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]. May play roles in cilia formation and/or maintenance. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6NZK8-1; Sequence=Displayed; Name=2; IsoId=Q6NZK8-2; Sequence=VSP_029737, VSP_029739; Name=3; IsoId=Q6NZK8-3; Sequence=VSP_029738; Elongated cilia. Belongs to the protein-tyrosine phosphatase family. Non- receptor class PTPDC1 subfamily. Sequence=BAE20451.1; Type=Erroneous initiation; Evidence=; Sequence=BAE21357.1; Type=Erroneous initiation; Evidence=; phosphoprotein phosphatase activity protein tyrosine phosphatase activity nucleoplasm cytoplasm protein dephosphorylation smoothened signaling pathway protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity cell projection organization peptidyl-tyrosine dephosphorylation cilium assembly uc007qij.1 uc007qij.2 uc007qij.3 uc007qij.4 
ENSMUST00000222029.2 Slc6a18 ENSMUST00000222029.2 solute carrier family 6 (neurotransmitter transporter), member 18, transcript variant 1 (from RefSeq NM_001040692.3) B0at3 ENSMUST00000222029.1 NM_001040692 O88576 O88577 O88578 O88579 O88580 O88581 Q91XG6 S6A18_MOUSE Slc6a18 Xt2 Xtrp2 uc007rds.1 uc007rds.2 uc007rds.3 uc007rds.4 Symporter that transports one amino acid molecule together with two sodium and one chloride ions in kidneys and plays a role in the neutral amino acids reabsorption (PubMed:19478081, PubMed:26240152, PubMed:20377526). Preferentially transports neutral amino acids such as L-glycine and L-alanine but also other neutral amino acids (PubMed:19478081, PubMed:26240152, PubMed:20377526). Required CLTRN for cell surface expression and for its amino acid transporter activity (PubMed:26240152, PubMed:20377526). The transport mechanism is pH- independent (PubMed:19478081). Reaction=chloride(out) + L-alanine(out) + 2 Na(+)(out) = chloride(in) + L-alanine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71311, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57972; Evidence= Reaction=chloride(out) + glycine(out) + 2 Na(+)(out) = chloride(in) + glycine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70691, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57305; Evidence=; Reaction=chloride(out) + L-methionine(out) + 2 Na(+)(out) = chloride(in) + L-methionine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71303, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57844; Evidence=; Reaction=chloride(out) + L-valine(out) + 2 Na(+)(out) = chloride(in) + L-valine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71307, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57762; Evidence=; Reaction=chloride(out) + L-isoleucine(out) + 2 Na(+)(out) = chloride(in) + L-isoleucine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71299, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:58045; Evidence=; Reaction=chloride(out) + L-serine(out) + 2 Na(+)(out) = chloride(in) + L-serine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71315, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384; Evidence=; Reaction=chloride(out) + L-leucine(out) + 2 Na(+)(out) = chloride(in) + L-leucine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71279, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57427; Evidence=; Kinetic parameters: KM=0.79 mM for L-alanine (in the presence of CLTRN) ; KM=0.14 mM for L-alanine (in the presence of ACE2) ; KM=0.99 mM for L-glycine (in the presence of CLTRN) ; KM=0.27 mM for L-glycine (in the presence of ACE2) ; KM=0.9 mM for L-alanine (in the presence of CLTRN) ; KM=2.3 mM for L-glycine (in the presence of CLTRN) ; Interacts with CLTRN; this interaction regulates the trafficking of SLC6A18 to the cell membrane and its activity. Apical cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Note=In kidneys localizes to the apical membrane in distal segments of the proximal tubule (PubMed:19478081, PubMed:20377526). Cell membrane expression is CLTRN-dependent (PubMed:20377526). Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=A12; IsoId=O88576-1; Sequence=Displayed; Name=2; Synonyms=A11; IsoId=O88576-2; Sequence=VSP_050365; Name=3; Synonyms=B11; IsoId=O88576-3; Sequence=VSP_050364; Name=4; Synonyms=A10; IsoId=O88576-4; Sequence=VSP_050366, VSP_050367; Name=5; Synonyms=B9; IsoId=O88576-5; Sequence=VSP_050364, VSP_050366, VSP_050367; Name=6; Synonyms=A8; IsoId=O88576-6; Sequence=VSP_050363, VSP_050697; Expressed predominantly in kidney. Barely detectable at post natal day 0, reaching maximum expression after the third week of life. Animals lacking this protein exhibit no gross abnormalities and grow to adulthood, although they do exhibit hypertension. The elevated blood pressure appears to be attributable to a decreased level of renal glycine. High-affinity renal reabsorption of glycine is eliminated and intrarenal glycine concentration is reduced. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily. Human SLC6A18 has been shown to be an inactive protein. amino acid transmembrane transport neurotransmitter:sodium symporter activity protein binding plasma membrane integral component of plasma membrane neurotransmitter transport amino acid transport neutral amino acid transmembrane transporter activity symporter activity neutral amino acid transport membrane integral component of membrane apical plasma membrane brush border membrane uc007rds.1 uc007rds.2 uc007rds.3 uc007rds.4 
ENSMUST00000222050.2 Zfp37 ENSMUST00000222050.2 zinc finger protein 37, transcript variant 2 (from RefSeq NM_009554.5) ENSMUST00000222050.1 NM_009554 Q6P3Z4 Q6P3Z4_MOUSE Zfp37 uc008tbx.1 uc008tbx.2 uc008tbx.3 uc008tbx.4 Nucleus nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc008tbx.1 uc008tbx.2 uc008tbx.3 uc008tbx.4 
ENSMUST00000222054.2 4930425K24Rik ENSMUST00000222054.2 4930425K24Rik (from geneSymbol) AK019584 ENSMUST00000222054.1 uc288jgb.1 uc288jgb.2 uc288jgb.1 uc288jgb.2 
ENSMUST00000222059.2 A530058O07Rik ENSMUST00000222059.2 A530058O07Rik (from geneSymbol) ENSMUST00000222059.1 uc288kys.1 uc288kys.2 uc288kys.1 uc288kys.2 
ENSMUST00000222069.2 5330409N07Rik ENSMUST00000222069.2 5330409N07Rik (from geneSymbol) AK030416 ENSMUST00000222069.1 uc288ilz.1 uc288ilz.2 uc288ilz.1 uc288ilz.2 
ENSMUST00000222087.4 Ifi30 ENSMUST00000222087.4 interferon gamma inducible protein 30 (from RefSeq NM_023065.3) ENSMUST00000222087.1 ENSMUST00000222087.2 ENSMUST00000222087.3 G3X911 GILT_MOUSE Gilt Ip30 NM_023065 Q3U0F9 Q9EP56 Q9ESY9 uc292ary.1 uc292ary.2 Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation. Dimer; disulfide-linked. Secreted Lysosome N-glycosylated. Sugar chains contain mannose-6-phosphate (By similarity). Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases (By similarity). Mice lacking GILT are deficient in generating major histocompatibility complex class-II-restricted CD4(+) T-cell responses to protein antigens that contain disulfide bonds. Mice are partially protected from Listeria monocytogenes infection, they exhibit reduced bacterial replication in spleen and liver. Bacterial escape from the phagosome is impaired in the macrophages of these mice. Both precursor form and mature form have thiol reductase activity. Belongs to the GILT family. Sequence=AAG00598.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; immune system process extracellular region lysosome cytosol disulfide oxidoreductase activity oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors antigen processing and presentation of exogenous peptide antigen via MHC class II cell junction antigen processing and presentation of exogenous peptide antigen via MHC class I intracellular membrane-bounded organelle negative regulation of fibroblast proliferation protein stabilization oxidation-reduction process uc292ary.1 uc292ary.2 
ENSMUST00000222088.3 Gm36839 ENSMUST00000222088.3 Gm36839 (from geneSymbol) ENSMUST00000222088.1 ENSMUST00000222088.2 uc288lxp.1 uc288lxp.2 uc288lxp.3 uc288lxp.1 uc288lxp.2 uc288lxp.3 
ENSMUST00000222094.2 Gm48597 ENSMUST00000222094.2 Gm48597 (from geneSymbol) ENSMUST00000222094.1 uc288pio.1 uc288pio.2 uc288pio.1 uc288pio.2 
ENSMUST00000222098.2 Gtpbp4 ENSMUST00000222098.2 GTP binding protein 4, transcript variant 1 (from RefSeq NM_027000.5) Crfg ENSMUST00000222098.1 GTPB4_MOUSE NM_027000 Nog1 Q99K16 Q99ME9 Q99P78 Q9CT02 uc007pkp.1 uc007pkp.2 uc007pkp.3 uc007pkp.4 Involved in the biogenesis of the 60S ribosomal subunit. Acts as TP53 repressor, preventing TP53 stabilization and cell cycle arrest. Associates with pre-60S ribosomal particles. Interacts with MINAS-60 (product of an alternative open reading frame of RBM10). Nucleus, nucleolus Ubiquitous. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. regulation of cyclin-dependent protein serine/threonine kinase activity nucleotide binding maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GTPase activity GTP binding nucleus nucleolus cytoplasm Golgi apparatus cytosol negative regulation of DNA replication negative regulation of cell proliferation negative regulation of cell-cell adhesion negative regulation of cell migration negative regulation of protein ubiquitination nuclear membrane negative regulation of collagen binding ribosome biogenesis perinuclear region of cytoplasm protein stabilization uc007pkp.1 uc007pkp.2 uc007pkp.3 uc007pkp.4 
ENSMUST00000222111.2 Gm47206 ENSMUST00000222111.2 Gm47206 (from geneSymbol) AK036753 ENSMUST00000222111.1 uc288iox.1 uc288iox.2 uc288iox.1 uc288iox.2 
ENSMUST00000222117.2 Gm47541 ENSMUST00000222117.2 Gm47541 (from geneSymbol) ENSMUST00000222117.1 LF204994 uc288jpn.1 uc288jpn.2 uc288jpn.1 uc288jpn.2 
ENSMUST00000222118.2 Gm47518 ENSMUST00000222118.2 Gm47518 (from geneSymbol) ENSMUST00000222118.1 uc288gvs.1 uc288gvs.2 uc288gvs.1 uc288gvs.2 
ENSMUST00000222121.2 Gm47357 ENSMUST00000222121.2 Gm47357 (from geneSymbol) ENSMUST00000222121.1 uc288fxb.1 uc288fxb.2 uc288fxb.1 uc288fxb.2 
ENSMUST00000222124.3 4930473H19Rik ENSMUST00000222124.3 RIKEN cDNA 4930473H19 gene, transcript variant 1 (from RefSeq NR_166711.1) ENSMUST00000222124.1 ENSMUST00000222124.2 NR_166711 uc007ojx.1 uc007ojx.2 uc007ojx.3 uc007ojx.4 uc007ojx.1 uc007ojx.2 uc007ojx.3 uc007ojx.4 
ENSMUST00000222131.3 Gm47450 ENSMUST00000222131.3 Gm47450 (from geneSymbol) ENSMUST00000222131.1 ENSMUST00000222131.2 uc288kkn.1 uc288kkn.2 uc288kkn.3 uc288kkn.1 uc288kkn.2 uc288kkn.3 
ENSMUST00000222132.2 4930428E07Rik ENSMUST00000222132.2 RIKEN cDNA 4930428E07 gene (from RefSeq NR_045943.1) ENSMUST00000222132.1 NR_045943 uc007nko.1 uc007nko.2 uc007nko.3 uc007nko.4 uc007nko.1 uc007nko.2 uc007nko.3 uc007nko.4 
ENSMUST00000222138.2 Gm48870 ENSMUST00000222138.2 Gm48870 (from geneSymbol) ENSMUST00000222138.1 LF248336 uc288kpa.1 uc288kpa.2 uc288kpa.1 uc288kpa.2 
ENSMUST00000222153.3 9130015A21Rik ENSMUST00000222153.3 RIKEN cDNA 9130015A21 gene, transcript variant 1 (from RefSeq NR_045050.1) ENSMUST00000222153.1 ENSMUST00000222153.2 NR_045050 uc007njk.1 uc007njk.2 uc007njk.3 uc007njk.4 uc007njk.5 uc007njk.6 uc007njk.1 uc007njk.2 uc007njk.3 uc007njk.4 uc007njk.5 uc007njk.6 
ENSMUST00000222155.2 Naip1 ENSMUST00000222155.2 NLR family, apoptosis inhibitory protein 1 (from RefSeq NM_008670.2) A2RT89 BIR1A_MOUSE Birc1a ENSMUST00000222155.1 NM_008670 Naip Q9JIB5 Q9QWK5 Q9R017 uc007rqs.1 uc007rqs.2 Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals (By similarity). Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains). Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 and APAF1 (By similarity). nucleotide binding cysteine-type endopeptidase inhibitor activity ATP binding cytoplasm apoptotic process negative regulation of peptidase activity basolateral plasma membrane peptidase inhibitor activity neuron projection neuronal cell body cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process perikaryon metal ion binding cellular response to estrogen stimulus uc007rqs.1 uc007rqs.2 
ENSMUST00000222157.2 7420701I03Rik ENSMUST00000222157.2 RIKEN cDNA 7420701I03 gene (from RefSeq NR_045860.1) ENSMUST00000222157.1 NR_045860 uc029rqv.1 uc029rqv.2 uc029rqv.3 uc029rqv.1 uc029rqv.2 uc029rqv.3 
ENSMUST00000222170.2 Gm47549 ENSMUST00000222170.2 Gm47549 (from geneSymbol) ENSMUST00000222170.1 uc288klk.1 uc288klk.2 uc288klk.1 uc288klk.2 
ENSMUST00000222173.2 Gm48747 ENSMUST00000222173.2 Gm48747 (from geneSymbol) ENSMUST00000222173.1 uc288gzo.1 uc288gzo.2 uc288gzo.1 uc288gzo.2 
ENSMUST00000222182.2 Gm6217 ENSMUST00000222182.2 Gm6217 (from geneSymbol) A0A1Y7VJK9 A0A1Y7VJK9_MOUSE ENSMUST00000222182.1 Gm6217 uc287jtc.1 uc287jtc.2 molecular_function cellular_component biological_process uc287jtc.1 uc287jtc.2 
ENSMUST00000222188.3 Gm48630 ENSMUST00000222188.3 Gm48630 (from geneSymbol) AK079974 ENSMUST00000222188.1 ENSMUST00000222188.2 uc288jio.1 uc288jio.2 uc288jio.3 uc288jio.1 uc288jio.2 uc288jio.3 
ENSMUST00000222190.2 Or2i1 ENSMUST00000222190.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A286YD85) A0A286YD85 A0A286YD85_MOUSE ENSMUST00000222190.1 Olfr94 Or2i1 uc289kyf.1 uc289kyf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289kyf.1 uc289kyf.2 
ENSMUST00000222214.2 ENSMUSG00000121737 ENSMUST00000222214.2 ENSMUSG00000121737 (from geneSymbol) ENSMUST00000222214.1 uc288nwq.1 uc288nwq.2 uc288nwq.1 uc288nwq.2 
ENSMUST00000222218.3 Gm34466 ENSMUST00000222218.3 Gm34466 (from geneSymbol) ENSMUST00000222218.1 ENSMUST00000222218.2 uc288mnd.1 uc288mnd.2 uc288mnd.3 uc288mnd.1 uc288mnd.2 uc288mnd.3 
ENSMUST00000222224.2 Gm47075 ENSMUST00000222224.2 Gm47075 (from geneSymbol) ENSMUST00000222224.1 uc288pdy.1 uc288pdy.2 uc288pdy.1 uc288pdy.2 
ENSMUST00000222230.2 Gm48166 ENSMUST00000222230.2 Gm48166 (from geneSymbol) ENSMUST00000222230.1 uc288nzc.1 uc288nzc.2 uc288nzc.1 uc288nzc.2 
ENSMUST00000222257.2 Gm47980 ENSMUST00000222257.2 Gm47980 (from geneSymbol) AK136011 ENSMUST00000222257.1 uc288jco.1 uc288jco.2 uc288jco.1 uc288jco.2 
ENSMUST00000222263.3 Gm40662 ENSMUST00000222263.3 Gm40662 (from geneSymbol) ENSMUST00000222263.1 ENSMUST00000222263.2 uc288kmi.1 uc288kmi.2 uc288kmi.3 uc288kmi.1 uc288kmi.2 uc288kmi.3 
ENSMUST00000222267.2 Gm20043 ENSMUST00000222267.2 Gm20043 (from geneSymbol) AK135998 ENSMUST00000222267.1 uc288kyj.1 uc288kyj.2 uc288kyj.1 uc288kyj.2 
ENSMUST00000222271.2 Gm47648 ENSMUST00000222271.2 Gm47648 (from geneSymbol) ENSMUST00000222271.1 uc288iyb.1 uc288iyb.2 uc288iyb.1 uc288iyb.2 
ENSMUST00000222281.3 4930547H16Rik ENSMUST00000222281.3 RIKEN cDNA 4930547H16 gene (from RefSeq NR_167672.1) ENSMUST00000222281.1 ENSMUST00000222281.2 NR_167672 uc288oiw.1 uc288oiw.2 uc288oiw.3 uc288oiw.1 uc288oiw.2 uc288oiw.3 
ENSMUST00000222288.2 Gm36128 ENSMUST00000222288.2 Gm36128 (from geneSymbol) ENSMUST00000222288.1 uc288fai.1 uc288fai.2 uc288fai.1 uc288fai.2 
ENSMUST00000222289.2 Gm47871 ENSMUST00000222289.2 Gm47871 (from geneSymbol) ENSMUST00000222289.1 uc288fpu.1 uc288fpu.2 uc288fpu.1 uc288fpu.2 
ENSMUST00000222293.2 Zp4-ps ENSMUST00000222293.2 zona pellucida glycoprotein 4, pseudogene (from RefSeq NR_027813.1) ENSMUST00000222293.1 NR_027813 uc007plc.1 uc007plc.2 uc007plc.3 uc007plc.1 uc007plc.2 uc007plc.3 
ENSMUST00000222297.2 Gm48491 ENSMUST00000222297.2 Gm48491 (from geneSymbol) ENSMUST00000222297.1 uc288kza.1 uc288kza.2 uc288kza.1 uc288kza.2 
ENSMUST00000222301.2 Or6c6b ENSMUST00000222301.2 Or6c6b (from geneSymbol) ENSMUST00000222301.1 NR_190759 uc287vxm.1 uc287vxm.2 uc287vxm.1 uc287vxm.2 
ENSMUST00000222304.2 Gm47804 ENSMUST00000222304.2 Gm47804 (from geneSymbol) ENSMUST00000222304.1 uc288ijk.1 uc288ijk.2 uc288ijk.1 uc288ijk.2 
ENSMUST00000222310.2 Ccdc85c ENSMUST00000222310.2 coiled-coil domain containing 85C (from RefSeq NM_001159910.2) CC85C_MOUSE E9Q6B2 ENSMUST00000222310.1 NM_001159910 uc011yrs.1 uc011yrs.2 uc011yrs.3 May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). May play an important role in cortical development, especially in the maintenance of radial glia (PubMed:22056358). May interact with ARVCF, CTNND1, CTNND2 and PKP4. Cell junction, tight junction Cell junction, adherens junction Note=Localizes to the apical junction of radial glia in the wall of lateral ventricles of the developing brain. Colocalizes with TJP1 on the meshwork-like structure of adherens junctions on the lateral ventricles wall. Predominantly expressed on the surface of the lateral ventricular walls of the developing cerebral cortex. Disrupted in the hemorrhagic hydrocephalus (hhy) mutant. The mutant animals shown sucortical heterotopia and non- obstructive hydrocephalus with frequent brain hemorrhage. Belongs to the CCDC85 family. molecular_function bicellular tight junction multicellular organism development cerebral cortex development cell junction apical junction complex uc011yrs.1 uc011yrs.2 uc011yrs.3 
ENSMUST00000222314.2 Sp4 ENSMUST00000222314.2 trans-acting transcription factor 4, transcript variant 1 (from RefSeq NM_009239.4) A0A1Y7VJR5 A0A1Y7VJR5_MOUSE ENSMUST00000222314.1 NM_009239 Sp4 uc007pif.1 uc007pif.2 uc007pif.3 uc007pif.4 uc007pif.5 Nucleus nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity nucleus nucleoplasm cytosol regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding positive regulation of nucleic acid-templated transcription uc007pif.1 uc007pif.2 uc007pif.3 uc007pif.4 uc007pif.5 
ENSMUST00000222328.2 Gm48847 ENSMUST00000222328.2 Gm48847 (from geneSymbol) ENSMUST00000222328.1 uc288gzx.1 uc288gzx.2 uc288gzx.1 uc288gzx.2 
ENSMUST00000222330.2 Gm40849 ENSMUST00000222330.2 Gm40849 (from geneSymbol) ENSMUST00000222330.1 uc288ffr.1 uc288ffr.2 uc288ffr.1 uc288ffr.2 
ENSMUST00000222336.3 Gm32939 ENSMUST00000222336.3 Gm32939 (from geneSymbol) ENSMUST00000222336.1 ENSMUST00000222336.2 uc288mky.1 uc288mky.2 uc288mky.3 uc288mky.1 uc288mky.2 uc288mky.3 
ENSMUST00000222338.2 Gm40437 ENSMUST00000222338.2 Gm40437 (from geneSymbol) ENSMUST00000222338.1 uc288had.1 uc288had.2 uc288had.1 uc288had.2 
ENSMUST00000222340.3 Eif1ad18 ENSMUST00000222340.3 Belongs to the eIF-1A family. (from UniProt A0A1Y7VNG9) A0A1Y7VNG9 A0A1Y7VNG9_MOUSE ENSMUST00000222340.1 ENSMUST00000222340.2 Eif1ad18 uc288ifv.1 uc288ifv.2 uc288ifv.3 Belongs to the eIF-1A family. RNA binding translation initiation factor activity translation translational initiation uc288ifv.1 uc288ifv.2 uc288ifv.3 
ENSMUST00000222341.2 Gm48408 ENSMUST00000222341.2 Gm48408 (from geneSymbol) AK079561 ENSMUST00000222341.1 uc288kyq.1 uc288kyq.2 uc288kyq.1 uc288kyq.2 
ENSMUST00000222349.2 Gm47728 ENSMUST00000222349.2 Gm47728 (from geneSymbol) ENSMUST00000222349.1 uc288mlb.1 uc288mlb.2 uc288mlb.1 uc288mlb.2 
ENSMUST00000222367.2 Gm47665 ENSMUST00000222367.2 Gm47665 (from geneSymbol) AK085732 ENSMUST00000222367.1 uc288ldh.1 uc288ldh.2 uc288ldh.1 uc288ldh.2 
ENSMUST00000222372.3 1700024I08Rik ENSMUST00000222372.3 RIKEN cDNA 1700024I08 gene (from RefSeq NR_126476.1) ENSMUST00000222372.1 ENSMUST00000222372.2 NR_126476 uc007qxz.1 uc007qxz.2 uc007qxz.3 uc007qxz.4 uc007qxz.5 uc007qxz.1 uc007qxz.2 uc007qxz.3 uc007qxz.4 uc007qxz.5 
ENSMUST00000222376.3 4930453C13Rik ENSMUST00000222376.3 4930453C13Rik (from geneSymbol) AK015450 ENSMUST00000222376.1 ENSMUST00000222376.2 uc288mnp.1 uc288mnp.2 uc288mnp.3 uc288mnp.1 uc288mnp.2 uc288mnp.3 
ENSMUST00000222380.3 Gm2721 ENSMUST00000222380.3 Gm2721 (from geneSymbol) AK039118 ENSMUST00000222380.1 ENSMUST00000222380.2 uc007oyi.1 uc007oyi.2 uc007oyi.3 uc007oyi.4 uc007oyi.5 uc007oyi.1 uc007oyi.2 uc007oyi.3 uc007oyi.4 uc007oyi.5 
ENSMUST00000222397.2 Gm49357 ENSMUST00000222397.2 Gm49357 (from geneSymbol) ENSMUST00000222397.1 uc288nnx.1 uc288nnx.2 uc288nnx.1 uc288nnx.2 
ENSMUST00000222398.2 Gm48692 ENSMUST00000222398.2 Gm48692 (from geneSymbol) AB350811 ENSMUST00000222398.1 uc288ihz.1 uc288ihz.2 uc288ihz.1 uc288ihz.2 
ENSMUST00000222401.4 Dio3os ENSMUST00000222401.4 deiodinase, iodothyronine type III, opposite strand (from RefSeq NR_002866.2) ENSMUST00000222401.1 ENSMUST00000222401.2 ENSMUST00000222401.3 NR_002866 uc007pbh.1 uc007pbh.2 uc007pbh.3 uc007pbh.4 uc007pbh.5 uc007pbh.6 uc007pbh.1 uc007pbh.2 uc007pbh.3 uc007pbh.4 uc007pbh.5 uc007pbh.6 
ENSMUST00000222404.2 Tes3-ps ENSMUST00000222404.2 Tes3-ps (from geneSymbol) A0A1Y7VP24 A0A1Y7VP24_MOUSE ENSMUST00000222404.1 LF199526 Tes3-ps uc288mrp.1 uc288mrp.2 ubiquitin ligase complex ubiquitin conjugating enzyme binding ubiquitin-like protein binding protein neddylation positive regulation of ubiquitin-protein transferase activity cullin family protein binding uc288mrp.1 uc288mrp.2 
ENSMUST00000222414.2 Rasef ENSMUST00000222414.2 RAS and EF hand domain containing, transcript variant 2 (from RefSeq NM_001404961.1) A0A1Y7VIT3 A0A1Y7VIT3_MOUSE ENSMUST00000222414.1 NM_001404961 Rasef uc290nhu.1 uc290nhu.2 GTPase activity calcium ion binding GTP binding uc290nhu.1 uc290nhu.2 
ENSMUST00000222417.3 Gm32834 ENSMUST00000222417.3 Gm32834 (from geneSymbol) ENSMUST00000222417.1 ENSMUST00000222417.2 uc288mun.1 uc288mun.2 uc288mun.3 uc288mun.1 uc288mun.2 uc288mun.3 
ENSMUST00000222426.2 Gm7544 ENSMUST00000222426.2 Gm7544 (from geneSymbol) A0A1Y7VJ58 A0A1Y7VJ58_MOUSE ENSMUST00000222426.1 Gm7544 uc287jte.1 uc287jte.2 uc287jte.1 uc287jte.2 
ENSMUST00000222435.2 Ftl1-ps1 ENSMUST00000222435.2 Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. (from UniProt Q9CPX4) AK002547 ENSMUST00000222435.1 Ftl1 Ftl1-ps1 Q9CPX4 Q9CPX4_MOUSE uc288oop.1 uc288oop.2 Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Belongs to the ferritin family. cell iron ion transport cellular iron ion homeostasis ferric iron binding metal ion binding uc288oop.1 uc288oop.2 
ENSMUST00000222438.2 Gm48885 ENSMUST00000222438.2 Gm48885 (from geneSymbol) ENSMUST00000222438.1 uc288ltx.1 uc288ltx.2 uc288ltx.1 uc288ltx.2 
ENSMUST00000222451.2 4930556H04Rik ENSMUST00000222451.2 4930556H04Rik (from geneSymbol) AK016144 ENSMUST00000222451.1 uc288ioo.1 uc288ioo.2 uc288ioo.1 uc288ioo.2 
ENSMUST00000222463.2 Gm40663 ENSMUST00000222463.2 Gm40663 (from geneSymbol) ENSMUST00000222463.1 uc288kml.1 uc288kml.2 uc288kml.1 uc288kml.2 
ENSMUST00000222465.2 Gm48613 ENSMUST00000222465.2 Gm48613 (from geneSymbol) ENSMUST00000222465.1 uc288fyz.1 uc288fyz.2 uc288fyz.1 uc288fyz.2 
ENSMUST00000222476.2 Gm30709 ENSMUST00000222476.2 Gm30709 (from geneSymbol) ENSMUST00000222476.1 uc288ntv.1 uc288ntv.2 uc288ntv.1 uc288ntv.2 
ENSMUST00000222480.2 Noxred1 ENSMUST00000222480.2 NADP+ dependent oxidoreductase domain containing 1 (from RefSeq NM_027744.1) ENSMUST00000222480.1 NM_027744 NXRD1_MOUSE Q9D3S5 uc007oio.1 uc007oio.2 uc007oio.3 Probable oxidoreductase. Belongs to the pyrroline-5-carboxylate reductase family. pyrroline-5-carboxylate reductase activity cellular_component oxidoreductase activity oxidation-reduction process L-proline biosynthetic process uc007oio.1 uc007oio.2 uc007oio.3 
ENSMUST00000222485.2 Pitrm1 ENSMUST00000222485.2 pitrilysin metallepetidase 1, transcript variant 1 (from RefSeq NM_145131.1) ENSMUST00000222485.1 Kiaa1104 NM_145131 Ntup1 PREP_MOUSE Pitrm1 Q3THC4 Q3TJI1 Q3TPP0 Q3URQ8 Q4KUG2 Q4KUG3 Q6ZPX6 Q8K411 Q922N1 Q9CV63 uc007pjx.1 uc007pjx.2 uc007pjx.3 uc007pjx.4 Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently. It is also able to degrade amyloid-beta protein 42. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Mainly exists in a closed and catalytically competent conformation but a closed-to-open switch allows substrate entry into the catalytic chamber. Substrate binding induces closure and dimerization. A disulfide bond may lock the enzyme in a closed conformation preventing substrate entry into the catalytic chamber, participating in redox regulation of the enzyme. Inhibited by metal- chelating agents. Inhibited by nickel and zinc excess, and slightly activated by manganese. Monomer and homodimer; homodimerization is induced by binding of the substrate. Mitochondrion matrix Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K411-1; Sequence=Displayed; Name=2; IsoId=Q8K411-2; Sequence=VSP_020598; Name=3; IsoId=Q8K411-3; Sequence=VSP_020598, VSP_020599; Up-regulated transplantes nuclei derived from embryonic stem (ES) cells. A disulfide bond locks the enzyme in the closed conformation preventing substrate entry into the catalytic chamber. Belongs to the peptidase M16 family. PreP subfamily. Sequence=AAH06917.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; catalytic activity metalloendopeptidase activity mitochondrion mitochondrial matrix proteolysis peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding uc007pjx.1 uc007pjx.2 uc007pjx.3 uc007pjx.4 
ENSMUST00000222490.2 2210039B01Rik ENSMUST00000222490.2 RIKEN cDNA 2210039B01 gene (from RefSeq NR_044985.1) ENSMUST00000222490.1 NR_044985 uc029rtj.1 uc029rtj.2 uc029rtj.3 uc029rtj.1 uc029rtj.2 uc029rtj.3 
ENSMUST00000222492.3 Gm47796 ENSMUST00000222492.3 Gm47796 (from geneSymbol) ENSMUST00000222492.1 ENSMUST00000222492.2 uc288iys.1 uc288iys.2 uc288iys.3 uc288iys.1 uc288iys.2 uc288iys.3 
ENSMUST00000222493.3 Gm47792 ENSMUST00000222493.3 Gm47792 (from geneSymbol) ENSMUST00000222493.1 ENSMUST00000222493.2 uc288mlu.1 uc288mlu.2 uc288mlu.3 uc288mlu.1 uc288mlu.2 uc288mlu.3 
ENSMUST00000222495.3 Gm36529 ENSMUST00000222495.3 predicted gene, 36529, transcript variant 1 (from RefSeq NR_167928.1) ENSMUST00000222495.1 ENSMUST00000222495.2 NR_167928 uc007rdb.1 uc007rdb.2 uc007rdb.3 uc007rdb.1 uc007rdb.2 uc007rdb.3 
ENSMUST00000222508.2 Klhl28 ENSMUST00000222508.2 kelch-like 28 (from RefSeq NM_025707.3) Btbd5 ENSMUST00000222508.1 KLH28_MOUSE NM_025707 Q9CR40 Q9CYV0 uc007nqp.1 uc007nqp.2 uc007nqp.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CR40-1; Sequence=Displayed; Name=2; IsoId=Q9CR40-2; Sequence=VSP_009801; uc007nqp.1 uc007nqp.2 uc007nqp.3 
ENSMUST00000222511.2 Gm48138 ENSMUST00000222511.2 Gm48138 (from geneSymbol) ENSMUST00000222511.1 uc288pht.1 uc288pht.2 uc288pht.1 uc288pht.2 
ENSMUST00000222512.2 Gm48586 ENSMUST00000222512.2 Gm48586 (from geneSymbol) ENSMUST00000222512.1 uc288iqw.1 uc288iqw.2 uc288iqw.1 uc288iqw.2 
ENSMUST00000222517.2 Ctsl ENSMUST00000222517.2 Reaction=Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl- dipeptidase activity.; EC=3.4.22.15; Evidence=; (from UniProt Q543M3) AK159511 Ctsl ENSMUST00000222517.1 Q543M3 Q543M3_MOUSE uc007qyw.1 uc007qyw.2 uc007qyw.3 uc007qyw.4 Reaction=Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl- dipeptidase activity.; EC=3.4.22.15; Evidence=; Cytoplasmic vesicle, secretory vesicle, chromaffin granule Lysosome Belongs to the peptidase C1 family. proteolysis peptidase activity cysteine-type peptidase activity hydrolase activity uc007qyw.1 uc007qyw.2 uc007qyw.3 uc007qyw.4 
ENSMUST00000222522.2 Gm19792 ENSMUST00000222522.2 Gm19792 (from geneSymbol) ENSMUST00000222522.1 uc288nph.1 uc288nph.2 uc288nph.1 uc288nph.2 
ENSMUST00000222531.2 Gm48896 ENSMUST00000222531.2 Gm48896 (from geneSymbol) AK042602 ENSMUST00000222531.1 uc007nes.1 uc007nes.2 uc007nes.3 uc007nes.1 uc007nes.2 uc007nes.3 
ENSMUST00000222537.2 Gm48606 ENSMUST00000222537.2 Gm48606 (from geneSymbol) ENSMUST00000222537.1 uc288fbg.1 uc288fbg.2 uc288fbg.1 uc288fbg.2 
ENSMUST00000222542.3 Gm40287 ENSMUST00000222542.3 Gm40287 (from geneSymbol) ENSMUST00000222542.1 ENSMUST00000222542.2 uc288fao.1 uc288fao.2 uc288fao.3 uc288fao.1 uc288fao.2 uc288fao.3 
ENSMUST00000222543.2 Zdhhc22 ENSMUST00000222543.2 zinc finger, DHHC-type containing 22, transcript variant 2 (from RefSeq NM_001377025.1) A0PK84 ENSMUST00000222543.1 Gm262 NM_001377025 ZDH22_MOUSE Zdhhc22 uc288ibu.1 uc288ibu.2 Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (By similarity). Catalyzes the palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (By similarity). Might also mediate palmitoylation of CNN3 (Probable). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Interacts with CNN3. Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane ; Multi-pass membrane protein The DHHC domain is required for palmitoyltransferase activity. Belongs to the DHHC palmitoyltransferase family. endoplasmic reticulum Golgi apparatus plasma membrane protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity protein localization to plasma membrane uc288ibu.1 uc288ibu.2 
ENSMUST00000222544.2 Trim27 ENSMUST00000222544.2 E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:24144979). Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation (By similarity). Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys- 220' of WASHC1, leading to promote endosomal F-actin assembly (By similarity). Has a transcriptional repressor activity by cooperating with EPC1 (By similarity). Induces apoptosis by activating Jun N- terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events (By similarity). May function in male germ cell development (By similarity). Has DNA-binding activity and preferentially bound to double-stranded DNA (By similarity). Forms a complex with and ubiquitinates the ubiquitin- specific protease USP7, which in turn deubiquitinates RIPK1 resulting in the positive regulation of TNF-alpha-induced apoptosis (PubMed:24144979). In addition, acts with USP7 or PTPN11 as an inhibitor of the antiviral signaling pathway by promoting kinase TBK1 ubiquitination and degradation (By similarity). Acts as a negative regulator of NOD2 signaling by mediating ubiquitination of NOD2, promoting its degradation by the proteasome (By similarity). Alternatively, facilitates mitophagy via TBK1 activation (By similarity). Negatively regulates autophagy flux under basal conditions by directly polyubiquitinating ULK1 (By similarity). During starvation- induced autophagy, catalyzes non-degradative ubiquitination of the kinase STK38L promoting its activation and phosphorylation of ULK1 leading to its ubiquitination and degradation to restrain the amplitude and duration of autophagy (By similarity). (from UniProt Q62158) AK031744 ENSMUST00000222544.1 Q62157 Q62158 Q8C2Q5 Q99LK1 Rfp TRI27_MOUSE uc288led.1 uc288led.2 E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:24144979). Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation (By similarity). Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys- 220' of WASHC1, leading to promote endosomal F-actin assembly (By similarity). Has a transcriptional repressor activity by cooperating with EPC1 (By similarity). Induces apoptosis by activating Jun N- terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events (By similarity). May function in male germ cell development (By similarity). Has DNA-binding activity and preferentially bound to double-stranded DNA (By similarity). Forms a complex with and ubiquitinates the ubiquitin- specific protease USP7, which in turn deubiquitinates RIPK1 resulting in the positive regulation of TNF-alpha-induced apoptosis (PubMed:24144979). In addition, acts with USP7 or PTPN11 as an inhibitor of the antiviral signaling pathway by promoting kinase TBK1 ubiquitination and degradation (By similarity). Acts as a negative regulator of NOD2 signaling by mediating ubiquitination of NOD2, promoting its degradation by the proteasome (By similarity). Alternatively, facilitates mitophagy via TBK1 activation (By similarity). Negatively regulates autophagy flux under basal conditions by directly polyubiquitinating ULK1 (By similarity). During starvation- induced autophagy, catalyzes non-degradative ubiquitination of the kinase STK38L promoting its activation and phosphorylation of ULK1 leading to its ubiquitination and degradation to restrain the amplitude and duration of autophagy (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Homomultimerizes. Part of a complex consisting of TRIM27, USP7 and MAGEL2; directly interacts with USP7. Interacts with PML, EIF3S6, EPC1, CHD4 and EID1. Interacts with MAGED4, MAGEF1 and MAGEL2. Interacts with PTPN11. Interacts with autophagy receptor p62/SQSTM1. Q62158; Q8CIH5: Plcg2; NbExp=4; IntAct=EBI-642025, EBI-617954; Nucleus Cytoplasm Nucleus, PML body Early endosome Mitochondrion Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2. Co-localizes with p62/SQSTM1 and TBK1 in cytoplasmic structures that are closely associated with the mitochondria (By similarity). Widely expressed. High expression is detected in testis. Low levels were detected in spleen, thymus, cerebrum and cerebellum. The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6. TRIM27-deficient mice are resistant to TNF-alpha- induced apoptosis. Belongs to the TRIM/RBCC family. Sequence=AAA85354.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter fibrillar center negative regulation of adaptive immune response DNA binding ubiquitin-protein transferase activity protein binding nucleus nucleoplasm nucleolus cytoplasm endosome cytosol negative regulation of protein kinase activity zinc ion binding PML body transferase activity retromer complex nuclear membrane negative regulation of tumor necrosis factor production negative regulation of viral transcription Arp2/3 complex-mediated actin nucleation retrograde transport, endosome to Golgi identical protein binding innate immune response negative regulation of gene expression, epigenetic metal ion binding positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of actin nucleation ubiquitin protein ligase activity protein trimerization protein K63-linked ubiquitination interferon-gamma secretion negative regulation of calcium ion import negative regulation of interleukin-2 secretion negative regulation of viral release from host cell uc288led.1 uc288led.2 
ENSMUST00000222553.2 Gm31025 ENSMUST00000222553.2 Gm31025 (from geneSymbol) ENSMUST00000222553.1 uc288fpq.1 uc288fpq.2 uc288fpq.1 uc288fpq.2 
ENSMUST00000222557.2 Gm48762 ENSMUST00000222557.2 Gm48762 (from geneSymbol) ENSMUST00000222557.1 uc288evm.1 uc288evm.2 uc288evm.1 uc288evm.2 
ENSMUST00000222566.2 Gm2233 ENSMUST00000222566.2 predicted gene 2233 (from RefSeq NR_175313.1) ENSMUST00000222566.1 NR_175313 uc288mlh.1 uc288mlh.2 uc288mlh.1 uc288mlh.2 
ENSMUST00000222567.2 Gm47969 ENSMUST00000222567.2 Gm47969 (from geneSymbol) A0A1Y7VJH8 A0A1Y7VJH8_MOUSE ENSMUST00000222567.1 Gm47969 uc287jtl.1 uc287jtl.2 uc287jtl.1 uc287jtl.2 
ENSMUST00000222570.2 Prxl2c ENSMUST00000222570.2 peroxiredoxin like 2C (from RefSeq NM_025370.3) Aaed1 ENSMUST00000222570.1 NM_025370 PXL2C_MOUSE Q3UFP2 Q9CVT8 Q9D1A0 uc007qyt.1 uc007qyt.2 uc007qyt.3 May positively regulate ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis. Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C subfamily. cellular_component antioxidant activity positive regulation of glycolytic process oxidation-reduction process positive regulation of ERK1 and ERK2 cascade cellular oxidant detoxification uc007qyt.1 uc007qyt.2 uc007qyt.3 
ENSMUST00000222571.2 Gm34785 ENSMUST00000222571.2 Gm34785 (from geneSymbol) BC058654 ENSMUST00000222571.1 uc288jfz.1 uc288jfz.2 uc288jfz.1 uc288jfz.2 
ENSMUST00000222573.2 Gm47884 ENSMUST00000222573.2 Gm47884 (from geneSymbol) ENSMUST00000222573.1 uc288kvs.1 uc288kvs.2 uc288kvs.1 uc288kvs.2 
ENSMUST00000222575.2 Gm48161 ENSMUST00000222575.2 Gm48161 (from geneSymbol) ENSMUST00000222575.1 uc288lsw.1 uc288lsw.2 uc288lsw.1 uc288lsw.2 
ENSMUST00000222578.2 Gm47011 ENSMUST00000222578.2 Gm47011 (from geneSymbol) AK034074 ENSMUST00000222578.1 uc288kxu.1 uc288kxu.2 uc288kxu.1 uc288kxu.2 
ENSMUST00000222580.3 BB123696 ENSMUST00000222580.3 BB123696 (from geneSymbol) AK035586 ENSMUST00000222580.1 ENSMUST00000222580.2 uc007qnb.1 uc007qnb.2 uc007qnb.3 uc007qnb.4 uc007qnb.5 uc007qnb.1 uc007qnb.2 uc007qnb.3 uc007qnb.4 uc007qnb.5 
ENSMUST00000222586.2 Gm40999 ENSMUST00000222586.2 Gm40999 (from geneSymbol) AK034233 ENSMUST00000222586.1 uc288okc.1 uc288okc.2 uc288okc.1 uc288okc.2 
ENSMUST00000222596.2 Gm47374 ENSMUST00000222596.2 Gm47374 (from geneSymbol) ENSMUST00000222596.1 uc288gco.1 uc288gco.2 uc288gco.1 uc288gco.2 
ENSMUST00000222600.2 A030003K21Rik ENSMUST00000222600.2 A030003K21Rik (from geneSymbol) A030003K21Rik A0A1Y7VIM3 A0A1Y7VIM3_MOUSE ENSMUST00000222600.1 uc287jtd.1 uc287jtd.2 molecular_function cellular_component biological_process uc287jtd.1 uc287jtd.2 
ENSMUST00000222605.2 ENSMUSG00000121454 ENSMUST00000222605.2 ENSMUSG00000121454 (from geneSymbol) ENSMUST00000222605.1 uc288oap.1 uc288oap.2 uc288oap.1 uc288oap.2 
ENSMUST00000222611.2 Tmdd1 ENSMUST00000222611.2 Tmdd1 (from geneSymbol) A0A1Y7VIT9 A0A1Y7VIT9_MOUSE ENSMUST00000222611.1 Gm47841 Tmdd1 uc289bmv.1 uc289bmv.2 signal transduction membrane integral component of membrane uc289bmv.1 uc289bmv.2 
ENSMUST00000222614.2 Gm48735 ENSMUST00000222614.2 Gm48735 (from geneSymbol) ENSMUST00000222614.1 LF270978 uc288nqr.1 uc288nqr.2 uc288nqr.1 uc288nqr.2 
ENSMUST00000222616.3 Gm19951 ENSMUST00000222616.3 predicted gene, 19951 (from RefSeq NR_166738.1) ENSMUST00000222616.1 ENSMUST00000222616.2 NR_166738 uc288ioq.1 uc288ioq.2 uc288ioq.3 uc288ioq.1 uc288ioq.2 uc288ioq.3 
ENSMUST00000222619.2 Gm10457 ENSMUST00000222619.2 Gm10457 (from geneSymbol) AK132884 ENSMUST00000222619.1 uc288hah.1 uc288hah.2 uc288hah.1 uc288hah.2 
ENSMUST00000222625.2 Gm47404 ENSMUST00000222625.2 Gm47404 (from geneSymbol) ENSMUST00000222625.1 uc288kqs.1 uc288kqs.2 uc288kqs.1 uc288kqs.2 
ENSMUST00000222639.2 4833405L11Rik ENSMUST00000222639.2 4833405L11Rik (from geneSymbol) AK014656 ENSMUST00000222639.1 uc288frc.1 uc288frc.2 uc288frc.1 uc288frc.2 
ENSMUST00000222648.2 Gm34639 ENSMUST00000222648.2 Gm34639 (from geneSymbol) AK136628 ENSMUST00000222648.1 uc288lrq.1 uc288lrq.2 uc288lrq.1 uc288lrq.2 
ENSMUST00000222655.2 Gm47975 ENSMUST00000222655.2 Gm47975 (from geneSymbol) ENSMUST00000222655.1 uc288guc.1 uc288guc.2 uc288guc.1 uc288guc.2 
ENSMUST00000222662.2 Gm47872 ENSMUST00000222662.2 Gm47872 (from geneSymbol) ENSMUST00000222662.1 uc288fps.1 uc288fps.2 uc288fps.1 uc288fps.2 
ENSMUST00000222665.2 Gm48617 ENSMUST00000222665.2 Gm48617 (from geneSymbol) AK138732 ENSMUST00000222665.1 uc288fze.1 uc288fze.2 uc288fze.1 uc288fze.2 
ENSMUST00000222666.2 Gm48405 ENSMUST00000222666.2 Gm48405 (from geneSymbol) AK042673 ENSMUST00000222666.1 uc288jif.1 uc288jif.2 uc288jif.1 uc288jif.2 
ENSMUST00000222671.2 Gm48653 ENSMUST00000222671.2 Gm48653 (from geneSymbol) AK141055 ENSMUST00000222671.1 uc288heg.1 uc288heg.2 uc288heg.1 uc288heg.2 
ENSMUST00000222672.4 Snhg10 ENSMUST00000222672.4 Snhg10 (from geneSymbol) ENSMUST00000222672.1 ENSMUST00000222672.2 ENSMUST00000222672.3 KY467652 uc288iyd.1 uc288iyd.2 uc288iyd.3 uc288iyd.4 uc288iyd.1 uc288iyd.2 uc288iyd.3 uc288iyd.4 
ENSMUST00000222673.3 Gm34923 ENSMUST00000222673.3 Gm34923 (from geneSymbol) ENSMUST00000222673.1 ENSMUST00000222673.2 uc288gav.1 uc288gav.2 uc288gav.1 uc288gav.2 
ENSMUST00000222675.2 Gm35558 ENSMUST00000222675.2 Gm35558 (from geneSymbol) ENSMUST00000222675.1 uc288jgv.1 uc288jgv.2 uc288jgv.1 uc288jgv.2 
ENSMUST00000222678.2 Gm34016 ENSMUST00000222678.2 predicted gene, 34016 (from RefSeq NR_175331.1) ENSMUST00000222678.1 NR_175331 uc288hek.1 uc288hek.2 uc288hek.1 uc288hek.2 
ENSMUST00000222693.2 Gm48008 ENSMUST00000222693.2 Gm48008 (from geneSymbol) ENSMUST00000222693.1 uc288iaj.1 uc288iaj.2 uc288iaj.1 uc288iaj.2 
ENSMUST00000222699.2 Gm49384 ENSMUST00000222699.2 Nucleus (from UniProt A0A1Y7VLU2) A0A1Y7VLU2 A0A1Y7VLU2_MOUSE BC058344 ENSMUST00000222699.1 Gm49384 uc288gwd.1 uc288gwd.2 Nucleus Belongs to the DNA polymerase epsilon subunit B family. DNA binding DNA-directed DNA polymerase activity DNA replication DNA-dependent DNA replication epsilon DNA polymerase complex error-prone translesion synthesis uc288gwd.1 uc288gwd.2 
ENSMUST00000222709.2 Gm47833 ENSMUST00000222709.2 Gm47833 (from geneSymbol) ENSMUST00000222709.1 uc288exz.1 uc288exz.2 uc288exz.1 uc288exz.2 
ENSMUST00000222720.2 Gm46339 ENSMUST00000222720.2 Gm46339 (from geneSymbol) ENSMUST00000222720.1 LF232435 uc288ffz.1 uc288ffz.2 uc288ffz.1 uc288ffz.2 
ENSMUST00000222731.2 Rps6ka5 ENSMUST00000222731.2 ribosomal protein S6 kinase, polypeptide 5, transcript variant 2 (from RefSeq NM_001330702.1) ENSMUST00000222731.1 KS6A5_MOUSE Msk1 NM_001330702 Q8C050 Q8CI92 uc007osu.1 uc007osu.2 uc007osu.3 Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (By similarity)(PubMed:11553624, PubMed:11909979, PubMed:16806820). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:16806820). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:11553624). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (By similarity). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (By similarity). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:15870105, PubMed:16517600). May also phosphorylate 'Ser-28' of histone H3 (PubMed:11441012, PubMed:15870105). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (By similarity). In lipopolysaccharide- stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (PubMed:18690222). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (PubMed:18690222). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (PubMed:12807421). Phosphorylates TRIM7 at 'Ser-106' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation at Ser-359, Thr-645 and Thr-764 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha, and by further autophosphorylation of Ser-211, Ser-375 and Ser-380 by the activated C-terminal kinase domain. The active N-terminal kinase domain finally phosphorylates downstream substrates, as well as Ser-814, Ser- 816 and Ser-822 in its own C-terminal region. Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA. Interacts with CREBBP and EP300 (By similarity). Q8C050; P11416: Rara; NbExp=2; IntAct=EBI-8391218, EBI-346736; Nucleus Event=Alternative splicing; Named isoforms=2; Name=2 ; IsoId=Q8C050-1; Sequence=Displayed; Name=1 ; Synonyms=5 ; IsoId=Q8C050-2; Sequence=VSP_050613; Ser-375 and Thr-645 phosphorylation is required for kinase activity. Ser-375 and Ser-211 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain. Phosphorylated at Ser-359, Thr-645 and Thr-764 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha. Autophosphorylated at Ser-814, Ser-816 and Ser-822 by the N-terminal kinase domain (By similarity). Ubiquitinated. Enzyme activity requires the presence of both kinase domains. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated protein phosphorylation inflammatory response kinase activity phosphorylation histone phosphorylation transferase activity positive regulation of histone phosphorylation positive regulation of histone acetylation intracellular signal transduction histone H3-S10 phosphorylation histone H3-S28 phosphorylation histone H2A-S1 phosphorylation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway uc007osu.1 uc007osu.2 uc007osu.3 
ENSMUST00000222732.2 Gm30655 ENSMUST00000222732.2 Gm30655 (from geneSymbol) ENSMUST00000222732.1 uc288nts.1 uc288nts.2 uc288nts.1 uc288nts.2 
ENSMUST00000222750.2 Gm36607 ENSMUST00000222750.2 Gm36607 (from geneSymbol) AK039809 ENSMUST00000222750.1 uc007rcy.1 uc007rcy.2 uc007rcy.1 uc007rcy.2 
ENSMUST00000222753.2 Gm48502 ENSMUST00000222753.2 Gm48502 (from geneSymbol) ENSMUST00000222753.1 uc288kzm.1 uc288kzm.2 uc288kzm.1 uc288kzm.2 
ENSMUST00000222760.2 Gm47836 ENSMUST00000222760.2 Gm47836 (from geneSymbol) AK052152 ENSMUST00000222760.1 uc288okh.1 uc288okh.2 uc288okh.1 uc288okh.2 
ENSMUST00000222762.2 Gm48227 ENSMUST00000222762.2 Gm48227 (from geneSymbol) ENSMUST00000222762.1 uc288fcd.1 uc288fcd.2 uc288fcd.1 uc288fcd.2 
ENSMUST00000222770.2 3732407C23Rik ENSMUST00000222770.2 3732407C23Rik (from geneSymbol) AK014404 ENSMUST00000222770.1 uc288eyk.1 uc288eyk.2 uc288eyk.1 uc288eyk.2 
ENSMUST00000222780.2 Gm48550 ENSMUST00000222780.2 Gm48550 (from geneSymbol) AK144582 ENSMUST00000222780.1 uc288mwu.1 uc288mwu.2 uc288mwu.1 uc288mwu.2 
ENSMUST00000222783.2 Hsd17b3 ENSMUST00000222783.2 Catalyzes the conversion of 17-oxosteroids to 17beta- hydroxysteroids (PubMed:32557858). Favors the reduction of androstenedione to testosterone (PubMed:32557858). Testosterone is the key androgen driving male development and function (PubMed:32190925, PubMed:32557858). Uses NADPH while the two other EDH17B enzymes use NADH (By similarity). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (By similarity). Plays a role in the rate-limiting- step for the maximum level of testosterone production by the testis but does not affect basal testosterone production (PubMed:32190925, PubMed:32557858). (from UniProt P70385) DHB3_MOUSE ENSMUST00000222783.1 Edh17b3 G3UWF9 Hsd17b3 P70385 U66827 uc288num.1 uc288num.2 Catalyzes the conversion of 17-oxosteroids to 17beta- hydroxysteroids (PubMed:32557858). Favors the reduction of androstenedione to testosterone (PubMed:32557858). Testosterone is the key androgen driving male development and function (PubMed:32190925, PubMed:32557858). Uses NADPH while the two other EDH17B enzymes use NADH (By similarity). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (By similarity). Plays a role in the rate-limiting- step for the maximum level of testosterone production by the testis but does not affect basal testosterone production (PubMed:32190925, PubMed:32557858). Reaction=a 17beta-hydroxy steroid + NADP(+) = a 17-oxo steroid + H(+) + NADPH; Xref=Rhea:RHEA:69284, ChEBI:CHEBI:15378, ChEBI:CHEBI:19168, ChEBI:CHEBI:35343, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:69286; Evidence=; Reaction=NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH; Xref=Rhea:RHEA:14981, ChEBI:CHEBI:15378, ChEBI:CHEBI:16422, ChEBI:CHEBI:17347, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.64; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:14983; Evidence=; Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH; Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:24618; Evidence=; Reaction=3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH = androst-5- en-3beta,17beta-diol + NADP(+); Xref=Rhea:RHEA:46628, ChEBI:CHEBI:2710, ChEBI:CHEBI:15378, ChEBI:CHEBI:28689, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46629; Evidence=; Reaction=17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha- androstan-3,17-dione + H(+) + NADPH; Xref=Rhea:RHEA:42120, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:16330, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42122; Evidence=; Reaction=androsterone + H(+) + NADPH = 5alpha-androstane-3alpha,17beta- diol + NADP(+); Xref=Rhea:RHEA:42156, ChEBI:CHEBI:15378, ChEBI:CHEBI:16032, ChEBI:CHEBI:36713, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42157; Evidence=; Reaction=3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH = 5alpha- androstane-3beta,17beta-diol + NADP(+); Xref=Rhea:RHEA:53480, ChEBI:CHEBI:15378, ChEBI:CHEBI:18329, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:541975; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53481; Evidence=; Reaction=androst-4-ene-3,11,17-trione + H(+) + NADPH = 17beta- hydroxyandrost-4-ene-3,11-dione + NADP(+); Xref=Rhea:RHEA:53484, ChEBI:CHEBI:2495, ChEBI:CHEBI:15378, ChEBI:CHEBI:34133, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53485; Evidence=; Reaction=11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH = 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+); Xref=Rhea:RHEA:53488, ChEBI:CHEBI:15378, ChEBI:CHEBI:27967, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:81481; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53489; Evidence=; Hormone biosynthesis; testosterone biosynthesis. Steroid metabolism. Endoplasmic reticulum Expressed in the testes. Expression is restricted to Sertoli cells in fetal life, peaks in neonatal mice, declines thereafter until the age of 21 days, and appears in Leydig cells in adulthood. Null males have increased circulating luteinizing hormone (LH) levels (PubMed:32557858). Null males present mild hypogonadism at adulthood represented by lowered weight of testes and several other androgen-sensitive tissues, a shortened anogenital distance, delayed puberty, and subfertility (fewer litters) (PubMed:32190925). No phenotypic alterations in the null female (PubMed:32190925, PubMed:32557858). Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. estradiol 17-beta-dehydrogenase activity endoplasmic reticulum lipid metabolic process steroid biosynthetic process oxidoreductase activity male genitalia development intracellular membrane-bounded organelle testosterone dehydrogenase (NAD+) activity testosterone 17-beta-dehydrogenase (NADP+) activity oxidation-reduction process testosterone biosynthetic process uc288num.1 uc288num.2 
ENSMUST00000222784.2 Macc1 ENSMUST00000222784.2 Nucleus (from UniProt E9PXX8) AK028965 E9PXX8 E9PXX8_MOUSE ENSMUST00000222784.1 Macc1 uc288kgd.1 uc288kgd.2 Nucleus RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding cytoplasm mitochondrion positive regulation of transcription from RNA polymerase II promoter uc288kgd.1 uc288kgd.2 
ENSMUST00000222801.2 Gm47587 ENSMUST00000222801.2 Gm47587 (from geneSymbol) ENSMUST00000222801.1 uc288nro.1 uc288nro.2 uc288nro.1 uc288nro.2 
ENSMUST00000222804.2 Gm47705 ENSMUST00000222804.2 Gm47705 (from geneSymbol) ENSMUST00000222804.1 uc288fod.1 uc288fod.2 uc288fod.1 uc288fod.2 
ENSMUST00000222807.2 Gm48423 ENSMUST00000222807.2 Gm48423 (from geneSymbol) AK139503 ENSMUST00000222807.1 uc007rbw.1 uc007rbw.2 uc007rbw.3 uc007rbw.1 uc007rbw.2 uc007rbw.3 
ENSMUST00000222815.2 Gm29968 ENSMUST00000222815.2 predicted gene, 29968 (from RefSeq NR_136895.1) ENSMUST00000222815.1 NR_136895 uc057knt.1 uc057knt.2 uc057knt.1 uc057knt.2 
ENSMUST00000222820.2 ENSMUSG00000121693 ENSMUST00000222820.2 ENSMUSG00000121693 (from geneSymbol) AK138386 ENSMUST00000222820.1 uc288gbd.1 uc288gbd.2 uc288gbd.1 uc288gbd.2 
ENSMUST00000222821.2 Ift43 ENSMUST00000222821.2 intraflagellar transport 43, transcript variant 1 (from RefSeq NM_001199843.1) ENSMUST00000222821.1 IFT43_MOUSE Ift43 NM_001199843 Q8CFI3 Q8K213 Q9DA69 uc007ohp.1 uc007ohp.2 uc007ohp.3 uc007ohp.4 As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base. Component of the IFT complex A (IFT-A) complex. IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B. Interacts directy with IFT122, WDR35 and TTC21B. Cytoplasm, cytoskeleton Cell projection, cilium Note=Associated with microtubules. Localized at the distal tip of the cilium. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9DA69-1; Sequence=Displayed; Name=2; IsoId=Q9DA69-2; Sequence=VSP_021171; Name=3; IsoId=Q9DA69-3; Sequence=VSP_021170; Expressed in the retina, iris-ciliary body, lens and cornea. Higher expression is observed in the retina, predominantly in the photoreceptor outer segment. Belongs to the IFT43 family. Sequence=AAH38915.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; molecular_function cytoplasm microtubule organizing center cytoskeleton cilium microtubule cytoskeleton cell projection organization intraciliary transport particle A intraciliary retrograde transport cell projection cilium assembly uc007ohp.1 uc007ohp.2 uc007ohp.3 uc007ohp.4 
ENSMUST00000222823.2 Gm40841 ENSMUST00000222823.2 Gm40841 (from geneSymbol) ENSMUST00000222823.1 uc288lrf.1 uc288lrf.2 uc288lrf.1 uc288lrf.2 
ENSMUST00000222830.2 Gm47411 ENSMUST00000222830.2 Gm47411 (from geneSymbol) ENSMUST00000222830.1 uc288kqo.1 uc288kqo.2 uc288kqo.1 uc288kqo.2 
ENSMUST00000222837.2 Gm48223 ENSMUST00000222837.2 Gm48223 (from geneSymbol) ENSMUST00000222837.1 uc288oal.1 uc288oal.2 uc288oal.1 uc288oal.2 
ENSMUST00000222844.2 Gm48369 ENSMUST00000222844.2 Gm48369 (from geneSymbol) AK157411 ENSMUST00000222844.1 uc288fyl.1 uc288fyl.2 uc288fyl.1 uc288fyl.2 
ENSMUST00000222858.3 Gm2270 ENSMUST00000222858.3 Gm2270 (from geneSymbol) AK132741 ENSMUST00000222858.1 ENSMUST00000222858.2 uc288iic.1 uc288iic.2 uc288iic.3 uc288iic.1 uc288iic.2 uc288iic.3 
ENSMUST00000222861.2 Gm49371 ENSMUST00000222861.2 Gm49371 (from geneSymbol) ENSMUST00000222861.1 uc288fgj.1 uc288fgj.2 uc288fgj.1 uc288fgj.2 
ENSMUST00000222864.2 AU017674 ENSMUST00000222864.2 AU017674 (from geneSymbol) ENSMUST00000222864.1 uc288ojk.1 uc288ojk.2 uc288ojk.1 uc288ojk.2 
ENSMUST00000222867.2 Tcl1b4 ENSMUST00000222867.2 T cell leukemia/lymphoma 1B, 4, transcript variant 1 (from RefSeq NM_001361906.1) A6H686 A6H686_MOUSE ENSMUST00000222867.1 NM_001361906 Tcl1b4 uc288iyl.1 uc288iyl.2 Belongs to the TCL1 family. protein serine/threonine kinase activator activity positive regulation of protein serine/threonine kinase activity uc288iyl.1 uc288iyl.2 
ENSMUST00000222871.2 Gm35330 ENSMUST00000222871.2 Gm35330 (from geneSymbol) ENSMUST00000222871.1 uc288kkt.1 uc288kkt.2 uc288kkt.1 uc288kkt.2 
ENSMUST00000222872.2 Gm48063 ENSMUST00000222872.2 Gm48063 (from geneSymbol) AK038565 ENSMUST00000222872.1 uc288ini.1 uc288ini.2 uc288ini.1 uc288ini.2 
ENSMUST00000222873.3 Gm30198 ENSMUST00000222873.3 Gm30198 (from geneSymbol) ENSMUST00000222873.1 ENSMUST00000222873.2 uc288its.1 uc288its.2 uc288its.3 uc288its.1 uc288its.2 uc288its.3 
ENSMUST00000222887.2 Gm47817 ENSMUST00000222887.2 Gm47817 (from geneSymbol) AK087315 ENSMUST00000222887.1 uc288hyv.1 uc288hyv.2 uc288hyv.1 uc288hyv.2 
ENSMUST00000222891.3 Gm47432 ENSMUST00000222891.3 Gm47432 (from geneSymbol) ENSMUST00000222891.1 ENSMUST00000222891.2 uc011ymk.1 uc011ymk.2 uc011ymk.3 uc011ymk.4 uc011ymk.5 uc011ymk.1 uc011ymk.2 uc011ymk.3 uc011ymk.4 uc011ymk.5 
ENSMUST00000222903.2 Gm36426 ENSMUST00000222903.2 Gm36426 (from geneSymbol) AK033777 ENSMUST00000222903.1 uc288ojw.1 uc288ojw.2 uc288ojw.1 uc288ojw.2 
ENSMUST00000222910.2 ENSMUSG00000121705 ENSMUST00000222910.2 ENSMUSG00000121705 (from geneSymbol) ENSMUST00000222910.1 uc288kum.1 uc288kum.2 uc288kum.1 uc288kum.2 
ENSMUST00000222911.3 Slc26a10 ENSMUST00000222911.3 solute carrier family 26, member 10 (from RefSeq NM_177615.4) A0A1Y7VKB5 ENSMUST00000222911.1 ENSMUST00000222911.2 NM_177615 Q5EBI0 S2610_MOUSE uc287vlu.1 uc287vlu.2 Chloride/bicarbonate exchanger. Membrane ; Multi-pass membrane protein Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Sequence=AAH89587.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence=; integral component of plasma membrane secondary active sulfate transmembrane transporter activity sulfate transport bicarbonate transmembrane transporter activity chloride transmembrane transporter activity sulfate transmembrane transporter activity antiporter activity anion:anion antiporter activity bicarbonate transport membrane integral component of membrane basolateral plasma membrane oxalate transmembrane transporter activity oxalate transport transmembrane transport anion transmembrane transport sulfate transmembrane transport chloride transmembrane transport uc287vlu.1 uc287vlu.2 
ENSMUST00000222913.2 9430031K09Rik ENSMUST00000222913.2 9430031K09Rik (from geneSymbol) AK020452 ENSMUST00000222913.1 uc288imu.1 uc288imu.2 uc288imu.1 uc288imu.2 
ENSMUST00000222916.2 Gm27528 ENSMUST00000222916.2 Gm27528 (from geneSymbol) EF648170 ENSMUST00000222916.1 uc288jdd.1 uc288jdd.2 uc288jdd.1 uc288jdd.2 
ENSMUST00000222917.2 Gm46348 ENSMUST00000222917.2 Gm46348 (from geneSymbol) ENSMUST00000222917.1 uc288gcr.1 uc288gcr.2 uc288gcr.1 uc288gcr.2 
ENSMUST00000222936.2 Gm47003 ENSMUST00000222936.2 Gm47003 (from geneSymbol) ENSMUST00000222936.1 uc288nvu.1 uc288nvu.2 uc288nvu.1 uc288nvu.2 
ENSMUST00000222938.2 Gm48079 ENSMUST00000222938.2 Gm48079 (from geneSymbol) ENSMUST00000222938.1 uc288kef.1 uc288kef.2 uc288kef.1 uc288kef.2 
ENSMUST00000222940.2 Gm48734 ENSMUST00000222940.2 Gm48734 (from geneSymbol) AK035111 ENSMUST00000222940.1 uc288nqu.1 uc288nqu.2 uc288nqu.1 uc288nqu.2 
ENSMUST00000222941.2 Kidins220 ENSMUST00000222941.2 kinase D-interacting substrate 220, transcript variant 3 (from RefSeq NM_001418116.1) A0A1Y7VME9 A0A1Y7VME9_MOUSE ENSMUST00000222941.1 Kidins220 NM_001418116 uc288fns.1 uc288fns.2 in utero embryonic development late endosome positive regulation of neuron projection development membrane integral component of membrane protein kinase regulator activity protein kinase binding PDZ domain binding macromolecular complex nerve growth factor signaling pathway regulation of protein kinase activity dendrite morphogenesis cellular response to nerve growth factor stimulus uc288fns.1 uc288fns.2 
ENSMUST00000222949.2 Gm48482 ENSMUST00000222949.2 Gm48482 (from geneSymbol) ENSMUST00000222949.1 uc288ezs.1 uc288ezs.2 uc288ezs.1 uc288ezs.2 
ENSMUST00000222952.2 Gm48381 ENSMUST00000222952.2 Gm48381 (from geneSymbol) DQ567455 ENSMUST00000222952.1 uc288iqj.1 uc288iqj.2 uc288iqj.1 uc288iqj.2 
ENSMUST00000222959.2 Gm47578 ENSMUST00000222959.2 Gm47578 (from geneSymbol) ENSMUST00000222959.1 uc287uly.1 uc287uly.2 uc287uly.1 uc287uly.2 
ENSMUST00000222961.2 Gm33785 ENSMUST00000222961.2 Gm33785 (from geneSymbol) ENSMUST00000222961.1 uc288hdh.1 uc288hdh.2 uc288hdh.1 uc288hdh.2 
ENSMUST00000222963.2 Gm6093 ENSMUST00000222963.2 predicted gene 6093, transcript variant 2 (from RefSeq NR_131141.1) ENSMUST00000222963.1 NR_131141 uc007qaj.1 uc007qaj.2 uc007qaj.1 uc007qaj.2 
ENSMUST00000222965.2 Gm48302 ENSMUST00000222965.2 Gm48302 (from geneSymbol) AK036770 ENSMUST00000222965.1 uc288oqs.1 uc288oqs.2 uc288oqs.1 uc288oqs.2 
ENSMUST00000222966.2 Gm47664 ENSMUST00000222966.2 Gm47664 (from geneSymbol) BC029724 ENSMUST00000222966.1 uc288ldk.1 uc288ldk.2 uc288ldk.1 uc288ldk.2 
ENSMUST00000222984.2 Gm47484 ENSMUST00000222984.2 Gm47484 (from geneSymbol) AK081163 ENSMUST00000222984.1 uc057bca.1 uc057bca.2 uc057bca.1 uc057bca.2 
ENSMUST00000223001.2 Gm34220 ENSMUST00000223001.2 predicted gene, 34220, transcript variant 2 (from RefSeq NR_189042.1) ENSMUST00000223001.1 NR_189042 uc056ysg.1 uc056ysg.2 uc056ysg.1 uc056ysg.2 
ENSMUST00000223012.2 Gm47882 ENSMUST00000223012.2 Gm47882 (from geneSymbol) AK148509 ENSMUST00000223012.1 uc288kvp.1 uc288kvp.2 uc288kvp.1 uc288kvp.2 
ENSMUST00000223019.2 Gm48139 ENSMUST00000223019.2 Gm48139 (from geneSymbol) ENSMUST00000223019.1 LF199672 uc288phv.1 uc288phv.2 uc288phv.1 uc288phv.2 
ENSMUST00000223022.2 Gm29687 ENSMUST00000223022.2 predicted gene, 29687 (from RefSeq NR_131149.1) ENSMUST00000223022.1 NR_131149 uc056ypw.1 uc056ypw.2 uc056ypw.1 uc056ypw.2 
ENSMUST00000223034.2 ENSMUSG00000121288 ENSMUST00000223034.2 ENSMUSG00000121288 (from geneSymbol) ENSMUST00000223034.1 uc288nyz.1 uc288nyz.2 uc288nyz.1 uc288nyz.2 
ENSMUST00000223043.2 Gm48681 ENSMUST00000223043.2 Gm48681 (from geneSymbol) ENSMUST00000223043.1 uc288kgi.1 uc288kgi.2 uc288kgi.1 uc288kgi.2 
ENSMUST00000223046.2 Gm48838 ENSMUST00000223046.2 Gm48838 (from geneSymbol) ENSMUST00000223046.1 uc288kie.1 uc288kie.2 uc288kie.1 uc288kie.2 
ENSMUST00000223047.2 Gm47997 ENSMUST00000223047.2 Gm47997 (from geneSymbol) ENSMUST00000223047.1 uc288fke.1 uc288fke.2 uc288fke.1 uc288fke.2 
ENSMUST00000223049.2 Gm26709 ENSMUST00000223049.2 Gm26709 (from geneSymbol) ENSMUST00000223049.1 uc288hdq.1 uc288hdq.2 uc288hdq.1 uc288hdq.2 
ENSMUST00000223050.2 Exoc3l4 ENSMUST00000223050.2 exocyst complex component 3-like 4, transcript variant 2 (from RefSeq NM_028807.4) A0A0R4J0W9 A0A0R4J0W9_MOUSE ENSMUST00000223050.1 Exoc3l4 NM_028807 uc007pcx.1 uc007pcx.2 uc007pcx.3 uc007pcx.4 uc007pcx.5 Belongs to the SEC6 family. exocyst exocytosis uc007pcx.1 uc007pcx.2 uc007pcx.3 uc007pcx.4 uc007pcx.5 
ENSMUST00000223052.2 Gm48888 ENSMUST00000223052.2 Gm48888 (from geneSymbol) AK045249 ENSMUST00000223052.1 uc288kpi.1 uc288kpi.2 uc288kpi.1 uc288kpi.2 
ENSMUST00000223056.2 Gm48137 ENSMUST00000223056.2 Gm48137 (from geneSymbol) AK037545 ENSMUST00000223056.1 uc288fxl.1 uc288fxl.2 uc288fxl.1 uc288fxl.2 
ENSMUST00000223060.2 Lpcat1 ENSMUST00000223060.2 lysophosphatidylcholine acyltransferase 1, transcript variant 3 (from RefSeq NM_001368682.1) Aytl2 ENSMUST00000223060.1 NM_001368682 PCAT1_MOUSE Q3TAX4 Q3TFD2 Q6NXZ6 Q8BG23 Q8BUX7 Q99JU6 uc007rdm.1 uc007rdm.2 uc007rdm.3 Exhibits both acyltransferase and acetyltransferase activities (PubMed:16704971, PubMed:18285344, PubMed:18156367). Activity is calcium-independent (PubMed:16704971, PubMed:18285344). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero- 3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn- glycero-3-phosphocholine or PC) (PubMed:16704971, PubMed:18285344, PubMed:18156367). Catalyzes the conversion 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1- palmitoyl LPC as acyl donors and acceptors, respectively (PubMed:16704971, PubMed:18285344). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O- alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:18285344). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16704971). Involved in the regulation of lipid droplet number and size (By similarity). Reaction=a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2- diacyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:12937, ChEBI:CHEBI:57287, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:58342; EC=2.3.1.23; Evidence= Reaction=1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O- alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:18461, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.67; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:10344, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:77286, ChEBI:CHEBI:77287; EC=2.3.1.25; Evidence=; Reaction=1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:33203, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64716, ChEBI:CHEBI:64840; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33204; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35983, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35984; Evidence=; Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37811, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:64496, ChEBI:CHEBI:72744; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37812; Evidence=; Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl- CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37819, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:77287, ChEBI:CHEBI:77304; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37820; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn- glycerol) + CoA; Xref=Rhea:RHEA:35851, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72829, ChEBI:CHEBI:75158; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35852; Evidence=; Reaction=1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37511, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74966, ChEBI:CHEBI:75017; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37512; Evidence=; Reaction=1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37655, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:64489, ChEBI:CHEBI:75062; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37656; Evidence=; Reaction=1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37839, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75216, ChEBI:CHEBI:75290; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37840; Evidence=; Reaction=1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37527, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:73858, ChEBI:CHEBI:75026; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37528; Evidence=; Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:37383, ChEBI:CHEBI:28610, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74667; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37384; Evidence=; Reaction=1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37843, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74968, ChEBI:CHEBI:75294; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37844; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA = 1- hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37855, ChEBI:CHEBI:57287, ChEBI:CHEBI:62620, ChEBI:CHEBI:72998, ChEBI:CHEBI:75301; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37856; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA = 1- hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37859, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:72998, ChEBI:CHEBI:75302; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37860; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA = 1- hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37863, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430, ChEBI:CHEBI:72998, ChEBI:CHEBI:75300; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37864; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37515, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:72998, ChEBI:CHEBI:75018; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37516; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37867, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:72998, ChEBI:CHEBI:75304; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37868; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3- phosphocholine + CoA; Xref=Rhea:RHEA:35991, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35992; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3- phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn- glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35995, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35996; Evidence=; Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl- sn-glycero-3-phosphocholine = 1-hexadecanoyl-2- (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37475, ChEBI:CHEBI:57287, ChEBI:CHEBI:72998, ChEBI:CHEBI:74298, ChEBI:CHEBI:74963; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37476; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1- hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37703, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:72998, ChEBI:CHEBI:75219; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37704; Evidence=; Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:43264, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:72998, ChEBI:CHEBI:82943; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43265; Evidence=; Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O- hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37719, ChEBI:CHEBI:44811, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64496; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37720; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1- acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37803, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:58168, ChEBI:CHEBI:75279; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37804; Evidence=; Reaction=a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2- hexadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:33315, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57970, ChEBI:CHEBI:64862; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33316; Evidence=; Reaction=1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl- CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:64840, ChEBI:CHEBI:75280; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37808; Evidence=; Not activated by inflammatory stimulation (PubMed:18285344). Inhibited by Cu(2+), Fe(2+), Ca(2+) and Mg(2+) (PubMed:18285344, PubMed:18156367). Activity is not affected by Co(2+) or Mn(2+) (PubMed:18285344). Kinetic parameters: KM=2.3 uM for 1-palmitoyl-LPC KM=3 uM for palmitoyl-CoA pH dependence: Optimum pH is 7.5. Lipid metabolism; phospholipid metabolism. Endoplasmic reticulum membrane ; Single-pass type II membrane protein Golgi apparatus membrane ; Single-pass type II membrane protein Cell membrane ; Single-pass type II membrane protein Lipid droplet Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3TFD2-1; Sequence=Displayed; Name=2; IsoId=Q3TFD2-2; Sequence=VSP_019914; Name=3; IsoId=Q3TFD2-3; Sequence=VSP_019913; Predominantly expressed in lung where it is enriched in alveolar type II cells. Expressed at lower levels in spleen and brain. Also detected in erythroleukemic cells and reticulocytes. Weakly or not expressed in other tissues. Expression increases steadily throughout embryogenesis and decreases slightly in the adult. Constitutively expressed. Not induced by inflammatory stimulation. The di-lysine motif may confer endoplasmic reticulum localization. The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. Sequence=AAH05662.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC32594.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BAC32760.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Golgi membrane calcium ion binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus lipid particle lipid metabolic process phospholipid metabolic process phospholipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups phosphatidylcholine acyl-chain remodeling surfactant homeostasis positive regulation of protein catabolic process metal ion binding 1-alkenylglycerophosphocholine O-acyltransferase activity 1-acylglycerophosphocholine O-acyltransferase activity 1-alkylglycerophosphocholine O-acyltransferase activity 1-alkylglycerophosphocholine O-acetyltransferase activity retina development in camera-type eye negative regulation of phosphatidylcholine biosynthetic process uc007rdm.1 uc007rdm.2 uc007rdm.3 
ENSMUST00000223066.2 Gm48504 ENSMUST00000223066.2 Gm48504 (from geneSymbol) AK154560 ENSMUST00000223066.1 uc288ezy.1 uc288ezy.2 uc288ezy.1 uc288ezy.2 
ENSMUST00000223069.2 Gm47890 ENSMUST00000223069.2 Gm47890 (from geneSymbol) AK081597 ENSMUST00000223069.1 uc288okp.1 uc288okp.2 uc288okp.1 uc288okp.2 
ENSMUST00000223070.2 Gm36864 ENSMUST00000223070.2 predicted gene, 36864, transcript variant 3 (from RefSeq NM_001378659.1) A0A1Y7VJE6 A0A1Y7VJE6_MOUSE ENSMUST00000223070.1 Gm36864 NM_001378659 uc291pcy.1 uc291pcy.2 membrane integral component of membrane uc291pcy.1 uc291pcy.2 
ENSMUST00000223084.3 Gm48544 ENSMUST00000223084.3 Gm48544 (from geneSymbol) AK030271 ENSMUST00000223084.1 ENSMUST00000223084.2 uc288ktz.1 uc288ktz.2 uc288ktz.3 uc288ktz.1 uc288ktz.2 uc288ktz.3 
ENSMUST00000223085.2 B020018J22Rik ENSMUST00000223085.2 Riken cDNA B020018J22 gene (from RefSeq NR_045950.1) ENSMUST00000223085.1 NR_045950 uc029ryg.1 uc029ryg.2 uc029ryg.1 uc029ryg.2 
ENSMUST00000223113.2 Gm48140 ENSMUST00000223113.2 Gm48140 (from geneSymbol) ENSMUST00000223113.1 uc288fbs.1 uc288fbs.2 uc288fbs.1 uc288fbs.2 
ENSMUST00000223115.2 Gm34557 ENSMUST00000223115.2 Gm34557 (from geneSymbol) ENSMUST00000223115.1 uc288mwt.1 uc288mwt.2 uc288mwt.1 uc288mwt.2 
ENSMUST00000223117.2 Gm47251 ENSMUST00000223117.2 Gm47251 (from geneSymbol) ENSMUST00000223117.1 uc288nyc.1 uc288nyc.2 uc288nyc.1 uc288nyc.2 
ENSMUST00000223126.2 Cast ENSMUST00000223126.2 calpastatin, transcript variant 5 (from RefSeq NM_001301157.1) Cast ENSMUST00000223126.1 NM_001301157 Q921U7 Q921U7_MOUSE uc011zbx.1 uc011zbx.2 uc011zbx.3 uc011zbx.4 This gene encodes an inhibitor of the calcium-dependent cysteine protease, calpain. This protein plays roles in multiple processes, including apoptosis, cell cycle regulation, and membrane fusion. Multiple protein isoforms exist which contain unique N-terminal domains, and multiple inhibitory domains that share homology with each other. Some isoforms may be tissue-specific. Two different pseudogenes of this gene are found on chromosome 19. [provided by RefSeq, Jul 2014]. Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. Belongs to the protease inhibitor I27 (calpastatin) family. uc011zbx.1 uc011zbx.2 uc011zbx.3 uc011zbx.4 
ENSMUST00000223127.2 Zyg11a ENSMUST00000223127.2 Belongs to the zyg-11 family. (from UniProt A0A1Y7VNL1) A0A1Y7VNL1 A0A1Y7VNL1_MOUSE BC022150 ENSMUST00000223127.1 Zyg11a uc290omz.1 uc290omz.2 Belongs to the zyg-11 family. uc290omz.1 uc290omz.2 
ENSMUST00000223133.2 Gm10465 ENSMUST00000223133.2 Gm10465 (from geneSymbol) AK142489 ENSMUST00000223133.1 uc288gin.1 uc288gin.2 uc288gin.1 uc288gin.2 
ENSMUST00000223136.3 Gm46323 ENSMUST00000223136.3 Gm46323 (from geneSymbol) ENSMUST00000223136.1 ENSMUST00000223136.2 uc288evj.1 uc288evj.2 uc288evj.3 uc288evj.1 uc288evj.2 uc288evj.3 
ENSMUST00000223141.2 Mdga2 ENSMUST00000223141.2 MAM domain containing glycosylphosphatidylinositol anchor 2, transcript variant B (from RefSeq NM_207010.2) ENSMUST00000223141.1 MDGA2_MOUSE Mamdc1 NM_207010 P60755 uc007nrl.1 uc007nrl.2 uc007nrl.3 uc007nrl.4 uc007nrl.5 May be involved in cell-cell interactions. Interacts (through the Ig-like domains) with NLGN2. Cell membrane ; Lipid-anchor, GPI- anchor molecular_function plasma membrane pattern specification process membrane anchored component of membrane glutamatergic synapse GABA-ergic synapse regulation of presynapse assembly uc007nrl.1 uc007nrl.2 uc007nrl.3 uc007nrl.4 uc007nrl.5 
ENSMUST00000223157.3 Gm47695 ENSMUST00000223157.3 Gm47695 (from geneSymbol) ENSMUST00000223157.1 ENSMUST00000223157.2 uc288kiq.1 uc288kiq.2 uc288kiq.3 uc288kiq.1 uc288kiq.2 uc288kiq.3 
ENSMUST00000223160.2 Trim9 ENSMUST00000223160.2 tripartite motif-containing 9, transcript variant 33 (from RefSeq NM_001405387.1) A0A1Y7VP88 A0A1Y7VP88_MOUSE ENSMUST00000223160.1 NM_001405387 Trim9 uc007ntt.1 uc007ntt.2 uc007ntt.3 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Cytoplasm, cytoskeleton zinc ion binding metal ion binding uc007ntt.1 uc007ntt.2 uc007ntt.3 
ENSMUST00000223163.3 Zfp72 ENSMUST00000223163.3 zinc finger protein 72, transcript variant 4 (from RefSeq NM_001426446.1) A0A1Y7VM41 ENSMUST00000223163.1 ENSMUST00000223163.2 NM_001426446 Q0VFY0 Q0VFY0_MOUSE Zfp72 uc288ool.1 uc288ool.2 nucleic acid binding nucleus regulation of transcription, DNA-templated positive regulation by host of viral release from host cell positive regulation by host of viral process metal ion binding uc288ool.1 uc288ool.2 
ENSMUST00000223164.2 Gm35618 ENSMUST00000223164.2 Gm35618 (from geneSymbol) AK133439 ENSMUST00000223164.1 uc288oiu.1 uc288oiu.2 uc288oiu.1 uc288oiu.2 
ENSMUST00000223165.2 Gm48631 ENSMUST00000223165.2 Gm48631 (from geneSymbol) ENSMUST00000223165.1 uc288jip.1 uc288jip.2 uc288jip.1 uc288jip.2 
ENSMUST00000223166.2 Togaram1 ENSMUST00000223166.2 TOG array regulator of axonemal microtubules 1, transcript variant 1 (from RefSeq NM_001364325.1) A0A1Y7VLS3 A0A1Y7VLS3_MOUSE ENSMUST00000223166.1 NM_001364325 Togaram1 uc007nqu.1 uc007nqu.2 uc007nqu.3 uc007nqu.4 uc007nqu.1 uc007nqu.2 uc007nqu.3 uc007nqu.4 
ENSMUST00000223169.2 Dynlt5 ENSMUST00000223169.2 dynein light chain Tctex-type 5, transcript variant 4 (from RefSeq NM_001374706.2) A0A1Y7VP18 A0A1Y7VP18_MOUSE Dynlt5 ENSMUST00000223169.1 NM_001374706 Tctex1d1 uc290odq.1 uc290odq.2 Belongs to the dynein light chain Tctex-type family. uc290odq.1 uc290odq.2 
ENSMUST00000223179.2 Ighg3 ENSMUST00000223179.2 Ighg3 (from geneSymbol) A0A1Y7VJN6 A0A1Y7VJN6_MOUSE AK037822 ENSMUST00000223179.1 Ighg3 uc288jrn.1 uc288jrn.2 antigen binding extracellular space phagocytosis, recognition phagocytosis, engulfment complement activation, classical pathway external side of plasma membrane membrane integral component of membrane immunoglobulin receptor binding immunoglobulin complex, circulating defense response to bacterium innate immune response B cell receptor signaling pathway positive regulation of B cell activation uc288jrn.1 uc288jrn.2 
ENSMUST00000223190.2 Gm48000 ENSMUST00000223190.2 Gm48000 (from geneSymbol) BC134390 ENSMUST00000223190.1 uc288okt.1 uc288okt.2 uc288okt.1 uc288okt.2 
ENSMUST00000223192.2 Gm49383 ENSMUST00000223192.2 Gm49383 (from geneSymbol) A0A1Y7VIU7 A0A1Y7VIU7_MOUSE ENSMUST00000223192.1 EU599049 Gm49383 uc288gwc.1 uc288gwc.2 uc288gwc.1 uc288gwc.2 
ENSMUST00000223194.2 Sirt5 ENSMUST00000223194.2 sirtuin 5 (from RefSeq NM_178848.3) ENSMUST00000223194.1 NM_178848 Q8K2C6 SIR5_MOUSE Sir2l5 uc007qga.1 uc007qga.2 uc007qga.3 uc007qga.4 NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:23806337, PubMed:21908771, PubMed:22076378, PubMed:24315375, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:19410549, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (By similarity). Activates SHMT2 by mediating its desuccinylation (By similarity). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (PubMed:24315375). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox (PubMed:23085393). Reaction=H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) = 2''-O-malonyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:47672, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11878, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:87831, ChEBI:CHEBI:87833; Evidence=; Reaction=H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O- succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:47668, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11877, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:87830, ChEBI:CHEBI:87832; Evidence=; Reaction=H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O- glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:47664, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11875, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:87828, ChEBI:CHEBI:87829; Evidence= Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Monomer. Homodimer (By similarity). Interacts with CPS1 (PubMed:19410549). Interacts with PCCA (PubMed:23438705). Q8K2C6; Q8C196: Cps1; NbExp=2; IntAct=EBI-2348809, EBI-2348828; Mitochondrion. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus. Detected in brain, liver, heart, kidney, lung, thymus, spleen, skeletal muscle, intestine, pancreas and testis (at protein level). In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity. Mice are born at an abnormal Mendelian ratio with the number of live-born pups reduced by 40% (PubMed:24076663). Surviving mice display a global protein hypersuccinylation and hyperglutarylation in both liver and skeletal muscle, while global lysine acetylation is not significantly impacted (PubMed:22076378, PubMed:24315375, PubMed:23806337, PubMed:24703693). Mice display elevated levels of blood ammonia during fasting, but otherwise are metabolically similar to wild-type (PubMed:24076663). No overt phenotype observed in mice on chow or high fat diet, suggesting that Sirt5 may be dispensable for basal homeostasis under these conditions (PubMed:24076663). After 48 hours of fasting, the absence of Cps1 activation leads to elevated blood ammonia levels, possibly due to the presence of succinylation at 'Lys-1291' in Cps1 (PubMed:22076378). Animals show a decrease of fatty acid oxidation and increase of acylcarnitines accumulation (PubMed:24315375). Belongs to the sirtuin family. Class III subfamily. The ability to deacetylate Uox in vivo is unclear. The anti- acetylated lysine antibody used in the assay is not fully specific and cross-reacts with some acylated lysines. It is therefore possible that it also recognizes N6-malonyllysine and N6-succinyllysine residues (PubMed:23085393). protein binding nucleus cytoplasm mitochondrion mitochondrial inner membrane mitochondrial intermembrane space mitochondrial matrix cytosol protein deacetylation zinc ion binding regulation of ketone biosynthetic process negative regulation of cardiac muscle cell apoptotic process hydrolase activity response to nutrient levels protein demalonylation peptidyl-lysine demalonylation protein desuccinylation peptidyl-lysine desuccinylation protein-malonyllysine demalonylase activity protein-succinyllysine desuccinylase activity metal ion binding protein-glutaryllysine deglutarylase activity protein deglutarylation peptidyl-lysine deglutarylation NAD+ binding negative regulation of reactive oxygen species metabolic process uc007qga.1 uc007qga.2 uc007qga.3 uc007qga.4 
ENSMUST00000223208.2 Gm48261 ENSMUST00000223208.2 Gm48261 (from geneSymbol) ENSMUST00000223208.1 uc288kna.1 uc288kna.2 uc288kna.1 uc288kna.2 
ENSMUST00000223212.2 Gm49749 ENSMUST00000223212.2 Gm49749 (from geneSymbol) AK086840 ENSMUST00000223212.1 uc288hpl.1 uc288hpl.2 uc288hpl.1 uc288hpl.2 
ENSMUST00000223213.2 Gm47138 ENSMUST00000223213.2 Gm47138 (from geneSymbol) ENSMUST00000223213.1 uc288ioh.1 uc288ioh.2 uc288ioh.1 uc288ioh.2 
ENSMUST00000223217.2 3110009F21Rik ENSMUST00000223217.2 RIKEN cDNA 3110009F21 gene (from RefSeq NR_045466.1) ENSMUST00000223217.1 NR_045466 uc007pbg.1 uc007pbg.2 uc007pbg.3 uc007pbg.4 uc007pbg.1 uc007pbg.2 uc007pbg.3 uc007pbg.4 
ENSMUST00000223220.2 Pgf ENSMUST00000223220.2 Secreted (from UniProt A0A1Y7VIW3) A0A1Y7VIW3 A0A1Y7VIW3_MOUSE AK042891 ENSMUST00000223220.1 Pgf uc007ogq.1 uc007ogq.2 uc007ogq.3 uc007ogq.4 Secreted Belongs to the PDGF/VEGF growth factor family. signal transduction growth factor activity membrane uc007ogq.1 uc007ogq.2 uc007ogq.3 uc007ogq.4 
ENSMUST00000223229.2 Gm48253 ENSMUST00000223229.2 Gm48253 (from geneSymbol) ENSMUST00000223229.1 uc288kmr.1 uc288kmr.2 uc288kmr.1 uc288kmr.2 
ENSMUST00000223236.3 Ubl5c ENSMUST00000223236.3 Ubl5c (from geneSymbol) A0A1Y7VKT9 A0A1Y7VKT9_MOUSE ENSMUST00000223236.1 ENSMUST00000223236.2 Gm16381 Gm2001 Ubl5b Ubl5c uc288ien.1 uc288ien.2 uc288ien.3 mRNA splicing, via spliceosome molecular_function cellular_component nucleus cytoplasm cellular protein modification process biological_process protein tag uc288ien.1 uc288ien.2 uc288ien.3 
ENSMUST00000223245.2 Gm47982 ENSMUST00000223245.2 Gm47982 (from geneSymbol) ENSMUST00000223245.1 uc288guf.1 uc288guf.2 uc288guf.1 uc288guf.2 
ENSMUST00000223248.2 Gm48593 ENSMUST00000223248.2 Gm48593 (from geneSymbol) ENSMUST00000223248.1 uc288ohx.1 uc288ohx.2 uc288ohx.1 uc288ohx.2 
ENSMUST00000223268.2 Nnt ENSMUST00000223268.2 Reaction=H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+); Xref=Rhea:RHEA:47992, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349; EC=7.1.1.1; Evidence=; (from UniProt Q8BGK0) AK033282 ENSMUST00000223268.1 Nnt Q8BGK0 Q8BGK0_MOUSE uc288qep.1 uc288qep.2 Reaction=H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+); Xref=Rhea:RHEA:47992, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349; EC=7.1.1.1; Evidence=; In the N-terminal section; belongs to the AlaDH/PNT family. membrane integral component of membrane oxidoreductase activity oxidation-reduction process uc288qep.1 uc288qep.2 
ENSMUST00000223270.2 A930023M06Rik ENSMUST00000223270.2 A930023M06Rik (from geneSymbol) AK020886 ENSMUST00000223270.1 uc288kff.1 uc288kff.2 uc288kff.1 uc288kff.2 
ENSMUST00000223272.2 Daam1 ENSMUST00000223272.2 dishevelled associated activator of morphogenesis 1, transcript variant 2 (from RefSeq NM_172464.3) DAAM1_MOUSE ENSMUST00000223272.1 NM_172464 Q3UHB4 Q6DFY0 Q6TAB8 Q80Y68 Q8BPM0 Q9CQQ2 uc007nux.1 uc007nux.2 uc007nux.3 uc007nux.4 Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments (By similarity). Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (PubMed:26526197). Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA. Interacts with INTU; INTU mediates the indirect interaction between DAAM1 and NPHP4 (By similarity). Q8BPM0; O15085-2: ARHGEF11; Xeno; NbExp=3; IntAct=EBI-772938, EBI-6169263; Cytoplasm Cytoplasm, cytoskeleton, cilium basal body Note=Perinuclear. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BPM0-1; Sequence=Displayed; Name=2; IsoId=Q8BPM0-2; Sequence=VSP_027771; Name=3; IsoId=Q8BPM0-3; Sequence=VSP_027772, VSP_027773; In early embryogenesis, expressed in embryonic and extraembryonic ectoderm. In later stages of gastrulation, expressed also in somites and ribs and posterior vertebrae of developing skeletal system. During organogenesis, expressed in CNS, PNS, stomach, liver and limb bud. Detected throughout the myocardial layer of the heart tube. Not expressed in the myocardium at 9.5 dpc but is present in epicardial cells and the pro-epicardial organ. At 10.5 dpc, expressed in the atrial and ventricular myocardia as well as the inter- ventricular septum. Continues to localize to the atrial and ventricular myocardia at 12.5 dpc as well as the ventricular trabeculae. The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus. The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity). Conditional knockout mice lacking Daam1 in myocardial cells show cardiomyopathy. Conditional knockout mice lacking Daam1 and Daam2 in myocardial cells show stronger cardiomyopathy. Belongs to the formin homology family. Sequence=AAH48856.1; Type=Erroneous initiation; Evidence=; stress fiber actin binding protein binding cytoplasm cytosol cytoskeleton plasma membrane cellular component organization Wnt signaling pathway Rho GTPase binding actin cytoskeleton organization motile cilium ciliary basal body identical protein binding cell projection uc007nux.1 uc007nux.2 uc007nux.3 uc007nux.4 
ENSMUST00000223275.3 Gm40909 ENSMUST00000223275.3 Gm40909 (from geneSymbol) ENSMUST00000223275.1 ENSMUST00000223275.2 uc288lxf.1 uc288lxf.2 uc288lxf.3 uc288lxf.1 uc288lxf.2 uc288lxf.3 
ENSMUST00000223278.2 Gm47838 ENSMUST00000223278.2 Gm47838 (from geneSymbol) ENSMUST00000223278.1 uc288okj.1 uc288okj.2 uc288okj.1 uc288okj.2 
ENSMUST00000223282.2 Eml5 ENSMUST00000223282.2 echinoderm microtubule associated protein like 5 (from RefSeq NM_001081191.1) EMAL5_MOUSE ENSMUST00000223282.1 NM_001081191 Q8BQM8 Q8BRL0 Q8R2W0 uc007orn.1 uc007orn.2 uc007orn.3 May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. Cytoplasm, cytoskeleton Belongs to the WD repeat EMAP family. Sequence=BAC31743.1; Type=Erroneous initiation; Evidence=; Sequence=BAC33148.1; Type=Erroneous initiation; Evidence=; cytoplasm cytoskeleton microtubule microtubule binding biological_process uc007orn.1 uc007orn.2 uc007orn.3 
ENSMUST00000223291.2 Dcaf4 ENSMUST00000223291.2 DDB1 and CUL4 associated factor 4, transcript variant 1 (from RefSeq NM_001165256.1) A0A1Y7VNZ0 A0A1Y7VNZ0_MOUSE Dcaf4 ENSMUST00000223291.1 NM_001165256 uc007odf.1 uc007odf.2 uc007odf.3 uc007odf.4 uc007odf.5 Cul4-RING E3 ubiquitin ligase complex uc007odf.1 uc007odf.2 uc007odf.3 uc007odf.4 uc007odf.5 
ENSMUST00000223295.2 Sult3a2 ENSMUST00000223295.2 Belongs to the sulfotransferase 1 family. (from UniProt G5E904) ENSMUST00000223295.1 G5E904 G5E904_MOUSE Sult3a2 uc287qla.1 uc287qla.2 Belongs to the sulfotransferase 1 family. molecular_function cellular_component sulfotransferase activity biological_process transferase activity uc287qla.1 uc287qla.2 
ENSMUST00000223298.2 Gm47207 ENSMUST00000223298.2 Gm47207 (from geneSymbol) ENSMUST00000223298.1 uc288iow.1 uc288iow.2 uc288iow.1 uc288iow.2 
ENSMUST00000223300.2 Gm10432 ENSMUST00000223300.2 predicted gene 10432 (from RefSeq NR_045741.1) ENSMUST00000223300.1 NR_045741 uc029rxj.1 uc029rxj.2 uc029rxj.1 uc029rxj.2 
ENSMUST00000223301.2 Gm3234 ENSMUST00000223301.2 Gm3234 (from geneSymbol) AK028473 ENSMUST00000223301.1 uc288jaq.1 uc288jaq.2 uc288jaq.1 uc288jaq.2 
ENSMUST00000223308.2 Lrrc74a ENSMUST00000223308.2 Lrrc74a (from geneSymbol) A0A1Y7VMD6 A0A1Y7VMD6_MOUSE ENSMUST00000223308.1 Lrrc74a uc288ibf.1 uc288ibf.2 molecular_function cellular_component biological_process uc288ibf.1 uc288ibf.2 
ENSMUST00000223310.2 ENSMUSG00000121806 ENSMUST00000223310.2 ENSMUSG00000121806 (from geneSymbol) AK137674 ENSMUST00000223310.1 uc288iff.1 uc288iff.2 uc288iff.1 uc288iff.2 
ENSMUST00000223323.2 E330035G20Rik ENSMUST00000223323.2 RIKEN cDNA E330035G20 gene (from RefSeq NR_166919.1) ENSMUST00000223323.1 NR_166919 uc007peo.1 uc007peo.2 uc007peo.3 uc007peo.1 uc007peo.2 uc007peo.3 
ENSMUST00000223326.2 Gm47088 ENSMUST00000223326.2 Gm47088 (from geneSymbol) AK085781 ENSMUST00000223326.1 uc288pdz.1 uc288pdz.2 uc288pdz.1 uc288pdz.2 
ENSMUST00000223334.3 Gm7550 ENSMUST00000223334.3 predicted gene 7550 (from RefSeq NR_033689.1) ENSMUST00000223334.1 ENSMUST00000223334.2 NR_033689 uc011ylv.1 uc011ylv.2 uc011ylv.3 uc011ylv.4 uc011ylv.1 uc011ylv.2 uc011ylv.3 uc011ylv.4 
ENSMUST00000223338.2 Zfp1008 ENSMUST00000223338.2 Zfp1008 (from geneSymbol) 6720489N17Rik A0A1Y7VJW0 A0A1Y7VJW0_MOUSE AK033001 ENSMUST00000223338.1 Zfp1008 uc288nqg.1 uc288nqg.2 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process uc288nqg.1 uc288nqg.2 
ENSMUST00000223343.2 Gm40660 ENSMUST00000223343.2 Gm40660 (from geneSymbol) ENSMUST00000223343.1 uc288kks.1 uc288kks.2 uc288kks.1 uc288kks.2 
ENSMUST00000223344.3 Tent4a ENSMUST00000223344.3 Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (By similarity). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication- dependent histone mRNA degradation via uridylation (By similarity). (from UniProt Q6PB75) BC059846 ENSMUST00000223344.1 ENSMUST00000223344.2 G3X948 PAPD7_MOUSE Papd7 Pols Q6PB75 Tent4a uc288oif.1 uc288oif.2 Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (By similarity). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication- dependent histone mRNA degradation via uridylation (By similarity). Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, ChEBI:CHEBI:173115; EC=2.7.7.19; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Cytoplasm Nucleus, nucleoplasm Note=Excluded from nucleolus, weak staining detected in the cytoplasm. Belongs to the DNA polymerase type-B-like family. Was originally thought to have DNA polymerase activity. nucleotide binding polynucleotide adenylyltransferase activity ATP binding nucleus nucleoplasm nucleolus cytoplasm Golgi apparatus mRNA processing transferase activity nucleotidyltransferase activity TRAMP complex nuclear membrane response to drug RNA polyadenylation metal ion binding negative regulation of nuclear-transcribed mRNA poly(A) tail shortening guanylyltransferase activity histone mRNA catabolic process snoRNA polyadenylation RNA 3' uridylation uc288oif.1 uc288oif.2 
ENSMUST00000223366.2 Or14j4 ENSMUST00000223366.2 Odorant receptor. (from UniProt Q7TRJ8) ENSMUST00000223366.1 Olfr115 Or14j4 Q7TRJ8 Q7TRJ8_MOUSE uc289lae.1 uc289lae.2 Odorant receptor. Membrane ; Multi- pass membrane protein G-protein coupled receptor activity olfactory receptor activity odorant binding plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289lae.1 uc289lae.2 
ENSMUST00000223367.2 Gm47602 ENSMUST00000223367.2 Gm47602 (from geneSymbol) ENSMUST00000223367.1 uc288nsi.1 uc288nsi.2 uc288nsi.1 uc288nsi.2 
ENSMUST00000223370.2 Gm47813 ENSMUST00000223370.2 Gm47813 (from geneSymbol) ENSMUST00000223370.1 uc288kja.1 uc288kja.2 uc288kja.1 uc288kja.2 
ENSMUST00000223396.2 Gdi2 ENSMUST00000223396.2 GDP dissociation inhibitor 2 (from RefSeq NM_008112.4) ENSMUST00000223396.1 GDIB_MOUSE Gdi3 NM_008112 Q541Z9 Q61598 Q8C530 Q9D8M9 uc007piu.1 uc007piu.2 uc007piu.3 GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A. Interacts with RHOH (By similarity). Interacts with the non- phosphorylated forms of RAB3A, RAB3B, RAB3C, RAB5A, RAB5B, RAB5C, RAB8B, RAB10, RAB12, RAB35, and RAB43; binds RAB3D to a lesser extent (By similarity). Interacts with RAB8A (GDP-bound inactive form); prevents RAB8A activation (PubMed:25860027). Interacts with DZIP1; negatively regulates the interaction of GDI2 with GDP-bound RAB8A (PubMed:25860027). Q61598; Q8BMD2: Dzip1; NbExp=2; IntAct=EBI-6665490, EBI-7089968; Cytoplasm Membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61598-1; Sequence=Displayed; Name=2; IsoId=Q61598-2; Sequence=VSP_010579; Belongs to the Rab GDI family. GDP-dissociation inhibitor activity Rab GDP-dissociation inhibitor activity GTPase activator activity protein binding cytoplasm Golgi apparatus small GTPase mediated signal transduction protein transport membrane vesicle-mediated transport Rab GTPase binding small GTPase binding myelin sheath positive regulation of GTPase activity synapse regulation of catalytic activity uc007piu.1 uc007piu.2 uc007piu.3 
ENSMUST00000223400.2 A030014E15Rik ENSMUST00000223400.2 A030014E15Rik (from geneSymbol) A030014E15Rik A0A1Y7VJV2 A0A1Y7VJV2_MOUSE ENSMUST00000223400.1 uc287jtb.1 uc287jtb.2 molecular_function cellular_component biological_process uc287jtb.1 uc287jtb.2 
ENSMUST00000223403.2 Gm40864 ENSMUST00000223403.2 Gm40864 (from geneSymbol) ENSMUST00000223403.1 uc288fki.1 uc288fki.2 uc288fki.1 uc288fki.2 
ENSMUST00000223429.3 Gm17746 ENSMUST00000223429.3 Gm17746 (from geneSymbol) AK031661 ENSMUST00000223429.1 ENSMUST00000223429.2 uc029rrm.1 uc029rrm.2 uc029rrm.3 uc029rrm.4 uc029rrm.1 uc029rrm.2 uc029rrm.3 uc029rrm.4 
ENSMUST00000223439.2 Gm47959 ENSMUST00000223439.2 Gm47959 (from geneSymbol) A0A1Y7VJ07 A0A1Y7VJ07_MOUSE ENSMUST00000223439.1 Gm47959 uc287jtg.1 uc287jtg.2 uc287jtg.1 uc287jtg.2 
ENSMUST00000223462.2 Gm47646 ENSMUST00000223462.2 Gm47646 (from geneSymbol) AK082991 ENSMUST00000223462.1 uc288izz.1 uc288izz.2 uc288izz.1 uc288izz.2 
ENSMUST00000223465.3 Gm48503 ENSMUST00000223465.3 Gm48503 (from geneSymbol) ENSMUST00000223465.1 ENSMUST00000223465.2 uc288kzi.1 uc288kzi.2 uc288kzi.3 uc288kzi.1 uc288kzi.2 uc288kzi.3 
ENSMUST00000223467.2 Nol8 ENSMUST00000223467.2 nucleolar protein 8, transcript variant 3 (from RefSeq NR_073168.1) ENSMUST00000223467.1 NOL8_MOUSE NR_073168 Nol8 Q059P5 Q3UHX0 Q504M4 Q8CDJ7 Q9CUR0 uc288mrt.1 uc288mrt.2 Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post- transcriptional level or in ribosome biogenesis in cancer cells (By similarity). Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7. Interacts with DDX18; the interaction is RNA- dependent. Interacts with DDX47; the interaction is RNA-dependent (By similarity). Nucleus, nucleolus Note=Localizes in the nucleolar-organizing region during ribosome biogenesis. Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q3UHX0-1; Sequence=Displayed; Name=2 ; IsoId=Q3UHX0-2; Sequence=VSP_052057; Phosphorylated. Sequence=BAB29660.1; Type=Erroneous initiation; Evidence=; Sequence=BAC26701.1; Type=Erroneous initiation; Evidence=; nucleic acid binding RNA binding nucleus nucleolus rRNA processing protein localization to nucleolus cellular response to leukemia inhibitory factor ribonucleoprotein complex uc288mrt.1 uc288mrt.2 
ENSMUST00000223468.2 Gm48871 ENSMUST00000223468.2 Gm48871 (from geneSymbol) ENSMUST00000223468.1 uc288kpe.1 uc288kpe.2 uc288kpe.1 uc288kpe.2 
ENSMUST00000223470.5 Eprn ENSMUST00000223470.5 Eprn (from geneSymbol) AK131952 ENSMUST00000223470.1 ENSMUST00000223470.2 ENSMUST00000223470.3 ENSMUST00000223470.4 uc007rdj.1 uc007rdj.2 uc007rdj.3 uc007rdj.4 uc007rdj.1 uc007rdj.2 uc007rdj.3 uc007rdj.4 
ENSMUST00000223472.2 Gm2912 ENSMUST00000223472.2 predicted gene 2912 (from RefSeq NR_188994.1) ENSMUST00000223472.1 NR_188994 uc288gvr.1 uc288gvr.2 uc288gvr.1 uc288gvr.2 
ENSMUST00000223477.2 Gm48444 ENSMUST00000223477.2 Gm48444 (from geneSymbol) ENSMUST00000223477.1 uc288kyw.1 uc288kyw.2 uc288kyw.1 uc288kyw.2 
ENSMUST00000223482.2 Speer6-ps1 ENSMUST00000223482.2 spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1 (from RefSeq NR_001581.3) ENSMUST00000223482.1 NR_001581 uc007pio.1 uc007pio.2 uc007pio.3 uc007pio.1 uc007pio.2 uc007pio.3 
ENSMUST00000223485.3 2900060N12Rik ENSMUST00000223485.3 RIKEN cDNA 2900060N12 gene, transcript variant 2 (from RefSeq NR_166876.1) ENSMUST00000223485.1 ENSMUST00000223485.2 NR_166876 uc288fnl.1 uc288fnl.2 uc288fnl.3 uc288fnl.1 uc288fnl.2 uc288fnl.3 
ENSMUST00000223486.2 Gm48350 ENSMUST00000223486.2 Gm48350 (from geneSymbol) ENSMUST00000223486.1 uc288pfx.1 uc288pfx.2 uc288pfx.1 uc288pfx.2 
ENSMUST00000223488.2 Gm47132 ENSMUST00000223488.2 Gm47132 (from geneSymbol) AK078354 ENSMUST00000223488.1 uc288ioi.1 uc288ioi.2 uc288ioi.1 uc288ioi.2 
ENSMUST00000223489.2 Gm48778 ENSMUST00000223489.2 Gm48778 (from geneSymbol) AK005425 ENSMUST00000223489.1 uc288lak.1 uc288lak.2 uc288lak.1 uc288lak.2 
ENSMUST00000223505.3 Gm40884 ENSMUST00000223505.3 Gm40884 (from geneSymbol) ENSMUST00000223505.1 ENSMUST00000223505.2 uc288gir.1 uc288gir.2 uc288gir.3 uc288gir.1 uc288gir.2 uc288gir.3 
ENSMUST00000223519.2 Gm47870 ENSMUST00000223519.2 Gm47870 (from geneSymbol) AK079370 ENSMUST00000223519.1 uc288gtg.1 uc288gtg.2 uc288gtg.1 uc288gtg.2 
ENSMUST00000223523.2 Gm47977 ENSMUST00000223523.2 Gm47977 (from geneSymbol) ENSMUST00000223523.1 uc288msm.1 uc288msm.2 uc288msm.1 uc288msm.2 
ENSMUST00000223531.2 Gm49703 ENSMUST00000223531.2 Gm49703 (from geneSymbol) ENSMUST00000223531.1 uc288iqt.1 uc288iqt.2 uc288iqt.1 uc288iqt.2 
ENSMUST00000223536.2 Gm47955 ENSMUST00000223536.2 Gm47955 (from geneSymbol) A0A1Y7VLE6 A0A1Y7VLE6_MOUSE ENSMUST00000223536.1 Gm47955 uc287jtf.1 uc287jtf.2 uc287jtf.1 uc287jtf.2 
ENSMUST00000223541.3 4930511J24Rik ENSMUST00000223541.3 4930511J24Rik (from geneSymbol) AK015759 ENSMUST00000223541.1 ENSMUST00000223541.2 uc288jfu.1 uc288jfu.2 uc288jfu.3 uc288jfu.1 uc288jfu.2 uc288jfu.3 
ENSMUST00000223545.2 Or1j8 ENSMUST00000223545.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q7TRY6) ENSMUST00000223545.1 NR_190753 Olfr335 Olfr335-ps Or1j8 Q7TRY6 Q7TRY6_MOUSE uc289vos.1 uc289vos.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc289vos.1 uc289vos.2 
ENSMUST00000223551.2 Wdcp ENSMUST00000223551.2 WD repeat and coiled coil containing, transcript variant 3 (from RefSeq NM_001422811.1) A0A1Y7VJP4 A0A1Y7VJP4_MOUSE ENSMUST00000223551.1 NM_001422811 Wdcp uc288esc.1 uc288esc.2 uc288esc.1 uc288esc.2 
ENSMUST00000223554.2 Btbd7 ENSMUST00000223554.2 BTB domain containing 7, transcript variant 3 (from RefSeq NR_165048.1) BTBD7_MOUSE ENSMUST00000223554.1 Fup1 Kiaa1525 NR_165048 Q80TC3 Q8BZY9 Q8CFE5 uc007ouq.1 uc007ouq.2 uc007ouq.3 Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell- scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CFE5-1; Sequence=Displayed; Name=2; IsoId=Q8CFE5-2; Sequence=VSP_013828, VSP_013829; Name=3; IsoId=Q8CFE5-3; Sequence=VSP_013830, VSP_013831; Specifically expressed in embryonic epithelia. Highly expressed in developing salivary glands at 13 dpc, a stage of particularly active salivary gland branching. Concentrated around the bottom and lower sides of forming clefts, while it is weakly or not expressed in other salivary epithelial regions. Also expressed in mesenchyme containing high levels of fibronectin. By fibronectin. Sequence=BAC65804.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function nucleus multicellular organism development regulation of branching involved in salivary gland morphogenesis morphogenesis of a branching epithelium uc007ouq.1 uc007ouq.2 uc007ouq.3 
ENSMUST00000223563.2 Dok3 ENSMUST00000223563.2 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function. (from UniProt Q9QZK7) AK155180 DOK3_MOUSE Dokl ENSMUST00000223563.1 Q9QZK7 uc288nck.1 uc288nck.2 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function. On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-325 and Tyr-343 are required for interaction with INPP5D. Only Tyr-325 is required for interaction with CSK. Binds ABL1 through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP. Q9QZK7; P03332: gag; Xeno; NbExp=3; IntAct=EBI-2906753, EBI-935477; Cytoplasm Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced.; Name=1; IsoId=Q9QZK7-1; Sequence=Displayed; Predominantly expressed in bone marrow, spleen and lung. Low levels in heart, brain, liver, muscle, thymus, kidney and testis. Highly expressed in B-cells and macrophages. PTB domain mediates receptor interaction. Constitutively tyrosine-phosphorylated. On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase. Overexpression of DOK3 inhibits the transforming activity of v-ABL, the ABL oncogene. [Isoform 1]: Major, and shortest isoform. Belongs to the DOK family. Type A subfamily. protein binding cytoplasm plasma membrane Ras protein signal transduction membrane uc288nck.1 uc288nck.2 
ENSMUST00000223586.2 Syt7 ENSMUST00000223586.2 synaptotagmin VII, transcript variant 2 (from RefSeq NM_173067.3) A4QPF1 E9PZA8 ENSMUST00000223586.1 NM_173067 Q0D2K7 Q8CF95 Q8CF96 Q9R0N7 SYT7_MOUSE Syt7 uc008gpp.1 uc008gpp.2 uc008gpp.3 uc008gpp.4 Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis. SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (PubMed:26738595). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (By similarity). Ca(2+)- regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (PubMed:16982801, PubMed:21041449). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (PubMed:18539119). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (PubMed:25860611). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (PubMed:24569478, PubMed:26738595). Probably mediates synaptic facilitation by directly increasing the probability of release (PubMed:26738595). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (PubMed:24569478). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (PubMed:18308938, PubMed:19171650). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (PubMed:20956309). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= Note=Binds 3 Ca(2+) ions per C2 domain. Homodimer (PubMed:10871604). Can also form heterodimers with SYT6, SYT9 and SYT10 (PubMed:10871604). Interacts with calmodulin (CALM1, CALM2 or CALM3) (PubMed:24569478). Interacts with CD63; required for localization to lysosomes (PubMed:21041449). Interacts with APP (PubMed:30429473). Cell membrane ; Single-pass membrane protein Presynaptic cell membrane ; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein Lysosome membrane ingle-pass membrane protein Cytoplasmic vesicle, phagosome membrane ; Single-pass membrane protein Peroxisome membrane ; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein Note=Localization to lysosomes is dependent on N-terminal palmitoylation and interaction with CD63. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Synaptotagmin VIIalpha , Syt7alpha ; IsoId=Q9R0N7-1; Sequence=Displayed; Name=2; Synonyms=Synaptotagmin VIIgamma , Syt7gamma ; IsoId=Q9R0N7-2; Sequence=VSP_058236; Name=3; Synonyms=Synaptotagmin VIIbeta , Syt7beta ; IsoId=Q9R0N7-3; Sequence=VSP_058235; Name=4; IsoId=Q9R0N7-4; Sequence=VSP_058237; Widely expressed. Expressed in insulin-secreting cells (PubMed:18308938). Present in glucagon-secreting cells (at protein level) (PubMed:19171650). The C2 domains bind Ca(2+) and membranes. Binding to membranes involves Ca(2+)-dependent phospholipid binding. Compared to other members of the family, the C2 domains of SYT7 dock and insert into cellular membranes in response to intracellular Ca(2+) concentrations that are lower than those required for other synaptotagmins. The two C2 domains bind independently to planar membranes, without interdomain cooperativity. Moreover, SYT7 C2 domains insert more deeply into membranes compared to other synaptotagmins. Palmitoylated at its vesicular N-terminus; palmitoylation is required for localization to lysosome and phagocytosis in macrophages. No visible phenotype. Mice were born at the expected Mendelian ratio and do not show gross abnormalities and/or obvious neurological defects. Mice have a normal life span and are fertile, although reproductive capacity is declining faster with age (PubMed:12925704). Embryonic fibroblasts from Syt7 deficient mice are less susceptible to Trypanosoma cruzi invasion, and display impaired lysosomal exocytosis and resealing after wounding (PubMed:12925704). Mutant mice display impaired insulin secretion: they exhibit normal insulin sensitivity and normal metabolic and Ca(2+) responses but impaired insulin release, due to Ca(2+)-sensing defects (PubMed:18308938). Impaired glucagon secretion (PubMed:19171650). Neurons show enhanced synaptic depression: spontaneous synaptic vesicle release is unaffected, while replenishment is impaired (PubMed:24569478). Abolished synaptic facilitation at all synapses except for mossy fiber synapses, where the remaining enhancement is consistent with use-dependent spike broadening that occurs at this synapse (PubMed:26738595). The loss of facilitation is not due to slowed recovery from depression. The initial probability of release and the presynaptic residual Ca(2+) signals are not affected (PubMed:26738595). [Isoform 1]: Major isoform. Belongs to the synaptotagmin family. SNARE binding plasma membrane repair phosphatidylserine binding calcium ion binding protein binding calmodulin binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding lysosome lysosomal membrane peroxisome peroxisomal membrane cytosol plasma membrane exocytosis phagocytosis synaptic vesicle regulation of dopamine secretion membrane integral component of membrane vesicle-mediated transport calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis cell junction clathrin binding dendrite transport vesicle membrane phagocytic vesicle membrane synaptic vesicle membrane cytoplasmic vesicle early phagosome synaptic vesicle recycling presynaptic membrane neuronal cell body axon terminus synapse regulation of bone remodeling metal ion binding calcium ion-regulated exocytosis of neurotransmitter regulation of phagocytosis regulation of insulin secretion regulation of glucagon secretion exocytic vesicle cellular response to calcium ion vesicle-mediated cholesterol transport phagosome-lysosome fusion glutamatergic synapse GABA-ergic synapse calcium-dependent activation of synaptic vesicle fusion regulation of synaptic vesicle endocytosis short-term synaptic potentiation calcium ion regulated lysosome exocytosis uc008gpp.1 uc008gpp.2 uc008gpp.3 uc008gpp.4 
ENSMUST00000223588.2 Gm47530 ENSMUST00000223588.2 Gm47530 (from geneSymbol) AK155369 ENSMUST00000223588.1 uc288mez.1 uc288mez.2 uc288mez.1 uc288mez.2 
ENSMUST00000223592.2 Gm30127 ENSMUST00000223592.2 Gm30127 (from geneSymbol) AK131720 ENSMUST00000223592.1 uc288lzy.1 uc288lzy.2 uc288lzy.1 uc288lzy.2 
ENSMUST00000223594.2 Gm48442 ENSMUST00000223594.2 Gm48442 (from geneSymbol) AK038094 ENSMUST00000223594.1 uc288qsq.1 uc288qsq.2 uc288qsq.1 uc288qsq.2 
ENSMUST00000223597.2 Gm48239 ENSMUST00000223597.2 Gm48239 (from geneSymbol) AK076564 ENSMUST00000223597.1 uc288quo.1 uc288quo.2 uc288quo.1 uc288quo.2 
ENSMUST00000223601.2 Gm47971 ENSMUST00000223601.2 Gm47971 (from geneSymbol) ENSMUST00000223601.1 uc288slt.1 uc288slt.2 uc288slt.1 uc288slt.2 
ENSMUST00000223605.2 Gm48732 ENSMUST00000223605.2 Gm48732 (from geneSymbol) ENSMUST00000223605.1 uc288odr.1 uc288odr.2 uc288odr.1 uc288odr.2 
ENSMUST00000223609.2 4930519K11Rik ENSMUST00000223609.2 4930519K11Rik (from geneSymbol) AK019684 ENSMUST00000223609.1 uc288rnl.1 uc288rnl.2 uc288rnl.1 uc288rnl.2 
ENSMUST00000223614.2 Gm4022 ENSMUST00000223614.2 Gm4022 (from geneSymbol) AK015147 ENSMUST00000223614.1 uc288usw.1 uc288usw.2 uc288usw.1 uc288usw.2 
ENSMUST00000223618.2 Gm47039 ENSMUST00000223618.2 Gm47039 (from geneSymbol) ENSMUST00000223618.1 uc288mgg.1 uc288mgg.2 uc288mgg.1 uc288mgg.2 
ENSMUST00000223629.2 Shd ENSMUST00000223629.2 src homology 2 domain-containing transforming protein D, transcript variant 5 (from RefSeq NM_001410667.1) ENSMUST00000223629.1 NM_001410667 O88834 Q3SYI7 SHD_MOUSE uc008dam.1 uc008dam.2 uc008dam.3 uc008dam.4 uc008dam.5 May function as an adapter protein. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88834-1; Sequence=Displayed; Name=2; IsoId=O88834-2; Sequence=VSP_019860; Specifically expressed in brain. Tyrosine phosphorylated by ABL. phosphotyrosine binding cellular_component uc008dam.1 uc008dam.2 uc008dam.3 uc008dam.4 uc008dam.5 
ENSMUST00000223651.2 Gm47212 ENSMUST00000223651.2 Gm47212 (from geneSymbol) ENSMUST00000223651.1 uc288vir.1 uc288vir.2 uc288vir.1 uc288vir.2 
ENSMUST00000223668.2 F830002E08Rik ENSMUST00000223668.2 F830002E08Rik (from geneSymbol) AK089566 ENSMUST00000223668.1 uc288lpr.1 uc288lpr.2 uc288lpr.1 uc288lpr.2 
ENSMUST00000223670.2 Gm40968 ENSMUST00000223670.2 Gm40968 (from geneSymbol) ENSMUST00000223670.1 uc288nhj.1 uc288nhj.2 uc288nhj.1 uc288nhj.2 
ENSMUST00000223679.2 Ndst2 ENSMUST00000223679.2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 (from RefSeq NM_010811.2) ENSMUST00000223679.1 Hsst2 NDST2_MOUSE NM_010811 P52850 Q3UDF4 Q549P5 uc007sks.1 uc007sks.2 Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha- D-glucosaminyl-[heparan sulfate](n); Xref=Rhea:RHEA:21980, Rhea:RHEA- COMP:9830, Rhea:RHEA-COMP:14602, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:140572; EC=2.8.2.8; Glycan metabolism; heparan sulfate biosynthesis. Glycan metabolism; heparin biosynthesis. Monomer. Golgi apparatus membrane ; Single- pass type II membrane protein Widely expressed in adult and throughout development. Mice are viable and fertile but have fewer connective-tissue-type mast cells; mast cells that remain having an altered morphology and severely reduced amounts of stored histamine and mast cell proteases. The presence of 4 different heparan sulfate N- deacetylase/N-sulfotransferase enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences. Belongs to the sulfotransferase 1 family. NDST subfamily. Golgi membrane regulation of angiotensin levels in blood catalytic activity Golgi apparatus glycosaminoglycan biosynthetic process sulfotransferase activity metabolic process cellular process heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [heparan sulfate]-glucosamine N-sulfotransferase activity membrane integral component of membrane transferase activity hydrolase activity deacetylase activity heparin biosynthetic process heparan sulfate N-acetylglucosaminyltransferase activity uc007sks.1 uc007sks.2 
ENSMUST00000223686.2 Gm47888 ENSMUST00000223686.2 Gm47888 (from geneSymbol) AK133732 ENSMUST00000223686.1 uc288lqe.1 uc288lqe.2 uc288lqe.1 uc288lqe.2 
ENSMUST00000223696.2 Gm48412 ENSMUST00000223696.2 Gm48412 (from geneSymbol) ENSMUST00000223696.1 uc288oca.1 uc288oca.2 uc288oca.1 uc288oca.2 
ENSMUST00000223707.2 4930455J16Rik ENSMUST00000223707.2 4930455J16Rik (from geneSymbol) AK015470 ENSMUST00000223707.1 uc288nhd.1 uc288nhd.2 uc288nhd.1 uc288nhd.2 
ENSMUST00000223708.2 ENSMUSG00000121672 ENSMUST00000223708.2 ENSMUSG00000121672 (from geneSymbol) BC040765 ENSMUST00000223708.1 uc288ovb.1 uc288ovb.2 uc288ovb.1 uc288ovb.2 
ENSMUST00000223710.2 5330431K02Rik ENSMUST00000223710.2 5330431K02Rik (from geneSymbol) AK019926 ENSMUST00000223710.1 uc288pmc.1 uc288pmc.2 uc288pmc.1 uc288pmc.2 
ENSMUST00000223716.3 ENSMUSG00000121681 ENSMUST00000223716.3 ENSMUSG00000121681 (from geneSymbol) ENSMUST00000223716.1 ENSMUST00000223716.2 uc288qsu.1 uc288qsu.2 uc288qsu.3 uc288qsu.1 uc288qsu.2 uc288qsu.3 
ENSMUST00000223722.2 Zfp131 ENSMUST00000223722.2 zinc finger protein 131, transcript variant 4 (from RefSeq NM_001302550.1) ENSMUST00000223722.1 NM_001302550 Q3UYZ4 Q80UU7 Q8C8D0 Q8K3J5 Q9D042 ZN131_MOUSE Znf131 uc007rzn.1 uc007rzn.2 uc007rzn.3 uc007rzn.4 This gene encodes a member of the BTB/POZ family of transcription factors. This protein has been found to act as a transcriptional activator and may regulate estrogen receptor signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling (By similarity). Plays a role during development and organogenesis as well as in the function of the adult central nervous system. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K3J5-1; Sequence=Displayed; Name=2; IsoId=Q8K3J5-2; Sequence=VSP_016924; Name=3; IsoId=Q8K3J5-3; Sequence=VSP_016925, VSP_016926; Ubiquitously expressed. Predominant expression is found in the developing central nervous system with strongest signals in the forebrain, midbrain, and hindbrain areas and in the neural tube. Expression found as early as 8.5 dpc. High expression is found in the developing limb buds of embryos. Monosumoylated at Lys-598 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling. Sumoylation does not interfere with ubiquitination (By similarity). Ubiquitinated. Belongs to the krueppel C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding nucleus nucleoplasm regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding intermediate filament cytoskeleton positive regulation of transcription from RNA polymerase II promoter metal ion binding uc007rzn.1 uc007rzn.2 uc007rzn.3 uc007rzn.4 
ENSMUST00000223733.2 Gm35215 ENSMUST00000223733.2 Gm35215 (from geneSymbol) AK054100 ENSMUST00000223733.1 uc288plo.1 uc288plo.2 uc288plo.1 uc288plo.2 
ENSMUST00000223735.2 Gm47906 ENSMUST00000223735.2 Gm47906 (from geneSymbol) AK034319 ENSMUST00000223735.1 uc288rot.1 uc288rot.2 uc288rot.1 uc288rot.2 
ENSMUST00000223736.2 Ddx46 ENSMUST00000223736.2 DEAD box helicase 46 (from RefSeq NM_001282055.1) DDX46_MOUSE ENSMUST00000223736.1 Kiaa0801 NM_001282055 Q569Z5 Q6ZQ42 Q8R0R6 uc288ndh.1 uc288ndh.2 Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre- mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Within the 17S U2 SnRNP complex, DDX46 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre- mRNA. Recruited to the 17S U2 SnRNP complex following release of DDX42; DDX42 and DDX46 bind the SF3B subcomplex in a competitive manner. Nucleus speckle Nucleus, Cajal body Note=Present in Cajal bodies (CBs) and nuclear speckles. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q569Z5-1; Sequence=Displayed; Name=2; IsoId=Q569Z5-2; Sequence=VSP_016859; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. Sequence=AAH26492.1; Type=Erroneous initiation; Evidence=; Sequence=AAH92240.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; Sequence=BAC98030.2; Type=Erroneous initiation; Evidence=; nucleotide binding mRNA splicing, via spliceosome fibrillar center nucleic acid binding RNA binding RNA helicase activity helicase activity ATP binding nucleus mRNA processing RNA splicing Cajal body membrane nuclear speck hydrolase activity uc288ndh.1 uc288ndh.2 
ENSMUST00000223738.2 Gm47202 ENSMUST00000223738.2 Gm47202 (from geneSymbol) AK045835 ENSMUST00000223738.1 uc288veg.1 uc288veg.2 uc288veg.1 uc288veg.2 
ENSMUST00000223745.2 Gm49146 ENSMUST00000223745.2 Gm49146 (from geneSymbol) ENSMUST00000223745.1 uc288sri.1 uc288sri.2 uc288sri.1 uc288sri.2 
ENSMUST00000223748.3 1700016H03Rik ENSMUST00000223748.3 1700016H03Rik (from geneSymbol) ENSMUST00000223748.1 ENSMUST00000223748.2 uc289sdz.1 uc289sdz.2 uc289sdz.3 uc289sdz.1 uc289sdz.2 uc289sdz.3 
ENSMUST00000223760.2 Gm4241 ENSMUST00000223760.2 Gm4241 (from geneSymbol) AK139204 ENSMUST00000223760.1 uc288oxs.1 uc288oxs.2 uc288oxs.1 uc288oxs.2 
ENSMUST00000223763.2 D130062J10Rik ENSMUST00000223763.2 D130062J10Rik (from geneSymbol) BC028466 ENSMUST00000223763.1 uc288plg.1 uc288plg.2 uc288plg.1 uc288plg.2 
ENSMUST00000223770.2 Tcstv7b ENSMUST00000223770.2 Tcstv7b (from geneSymbol) A0A286YDE9 A0A286YDE9_MOUSE AF067063 ENSMUST00000223770.1 Gm21731 uc029sdx.1 uc029sdx.2 uc029sdx.1 uc029sdx.2 
ENSMUST00000223772.2 Gm47007 ENSMUST00000223772.2 Gm47007 (from geneSymbol) AK043460 ENSMUST00000223772.1 uc007rrw.1 uc007rrw.2 uc007rrw.1 uc007rrw.2 
ENSMUST00000223773.2 Gm48430 ENSMUST00000223773.2 Gm48430 (from geneSymbol) AK156837 ENSMUST00000223773.1 uc288qso.1 uc288qso.2 uc288qso.1 uc288qso.2 
ENSMUST00000223774.2 Gm47414 ENSMUST00000223774.2 Gm47414 (from geneSymbol) ENSMUST00000223774.1 uc288rvf.1 uc288rvf.2 uc288rvf.1 uc288rvf.2 
ENSMUST00000223778.2 Ctsm ENSMUST00000223778.2 cathepsin M, transcript variant 1 (from RefSeq NM_022326.4) A0A0R4J182 A0A0R4J182_MOUSE Ctsm ENSMUST00000223778.1 NM_022326 uc007qwj.1 uc007qwj.2 uc007qwj.3 Belongs to the peptidase C1 family. proteolysis cysteine-type peptidase activity uc007qwj.1 uc007qwj.2 uc007qwj.3 
ENSMUST00000223781.2 A930014D07Rik ENSMUST00000223781.2 A930014D07Rik (from geneSymbol) AK020854 ENSMUST00000223781.1 uc007rpj.1 uc007rpj.2 uc007rpj.1 uc007rpj.2 
ENSMUST00000223784.2 Gm48802 ENSMUST00000223784.2 Gm48802 (from geneSymbol) AK053126 ENSMUST00000223784.1 uc288pyo.1 uc288pyo.2 uc288pyo.1 uc288pyo.2 
ENSMUST00000223791.2 Gm48342 ENSMUST00000223791.2 Gm48342 (from geneSymbol) AK037188 ENSMUST00000223791.1 uc288qfm.1 uc288qfm.2 uc288qfm.1 uc288qfm.2 
ENSMUST00000223800.2 Gm48453 ENSMUST00000223800.2 Gm48453 (from geneSymbol) AK054384 ENSMUST00000223800.1 uc288uxc.1 uc288uxc.2 uc288uxc.1 uc288uxc.2 
ENSMUST00000223815.2 Cts3 ENSMUST00000223815.2 cathepsin 3, transcript variant 2 (from RefSeq NM_054092.2) Cts3 ENSMUST00000223815.1 NM_054092 Q91ZD5 Q91ZD5_MOUSE uc007qwm.1 uc007qwm.2 uc007qwm.3 Belongs to the peptidase C1 family. cysteine-type endopeptidase activity extracellular space lysosome proteolysis cysteine-type peptidase activity proteolysis involved in cellular protein catabolic process uc007qwm.1 uc007qwm.2 uc007qwm.3 
ENSMUST00000223835.2 4921509O07Rik ENSMUST00000223835.2 RIKEN cDNA 4921509O07 gene (from RefSeq NR_045501.1) ENSMUST00000223835.1 NR_045501 uc029sdg.1 uc029sdg.2 uc029sdg.1 uc029sdg.2 
ENSMUST00000223836.2 Gm47649 ENSMUST00000223836.2 Gm47649 (from geneSymbol) AK157501 ENSMUST00000223836.1 uc288ozq.1 uc288ozq.2 uc288ozq.1 uc288ozq.2 
ENSMUST00000223838.2 Gm47791 ENSMUST00000223838.2 Gm47791 (from geneSymbol) A0A286YCP9 A0A286YCP9_MOUSE ENSMUST00000223838.1 Gm47791 LF192743 uc287jsq.1 uc287jsq.2 uc287jsq.1 uc287jsq.2 
ENSMUST00000223878.2 Arhgef33 ENSMUST00000223878.2 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BW86-1; Sequence=Displayed; Name=2; IsoId=Q8BW86-2; Sequence=VSP_039455; (from UniProt Q8BW86) AK053944 ARG33_MOUSE ENSMUST00000223878.1 Gm941 Q8BW86 uc289nbz.1 uc289nbz.2 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BW86-1; Sequence=Displayed; Name=2; IsoId=Q8BW86-2; Sequence=VSP_039455; molecular_function guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cellular_component biological_process regulation of Rho protein signal transduction uc289nbz.1 uc289nbz.2 
ENSMUST00000223880.2 Atxn7 ENSMUST00000223880.2 Involved in neurodegeneration. Acts as a component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation (By similarity). Necessary for microtubule cytoskeleton stabilization (By similarity). (from UniProt Q8R4I1) AF455111 ATX7_MOUSE E9QPX9 ENSMUST00000223880.1 Q8BL17 Q8R4I1 Sca7 uc288qwd.1 uc288qwd.2 Involved in neurodegeneration. Acts as a component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation (By similarity). Necessary for microtubule cytoskeleton stabilization (By similarity). Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP, TAF9 and ATXN7. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Interacts with SORBS1, PSMC1 and CRX. Interacts with TRRAP, GCN5L2 and TAF10 (By similarity). Interacts with alpha tubulin (By similarity). Q8R4I1; Q80YV3: Trrap; NbExp=3; IntAct=EBI-7990748, EBI-2942477; Nucleus Nucleus, nucleolus Nucleus matrix Cytoplasm, cytoskeleton Note=In addition to a diffuse distribution throughout the nucleus, it is associated with the nuclear matrix and the nucleolus. It is able to shuttle between the nucleus and cytoplasm (By similarity). Widely expressed in adult tissues, with the highest expression in heart, brain, liver and kidney. Proteolytically cleaved by caspase-7 (CASP7). Sumoylation has no effect on subcellular location or interaction with components of the STAGA complex. Belongs to the ataxin-7 family. microtubule cytoskeleton organization chromatin binding protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol cytoskeleton microtubule cytoskeleton nuclear matrix histone deubiquitination negative regulation of phosphorylation negative regulation of insulin-like growth factor receptor signaling pathway positive regulation of transcription from RNA polymerase II promoter uc288qwd.1 uc288qwd.2 
ENSMUST00000223888.2 Gm48765 ENSMUST00000223888.2 Gm48765 (from geneSymbol) ENSMUST00000223888.1 uc288mad.1 uc288mad.2 uc288mad.1 uc288mad.2 
ENSMUST00000223891.2 5530402G07Rik ENSMUST00000223891.2 5530402G07Rik (from geneSymbol) ENSMUST00000223891.1 uc288mha.1 uc288mha.2 uc288mha.1 uc288mha.2 
ENSMUST00000223900.2 Gm10739 ENSMUST00000223900.2 Gm10739 (from geneSymbol) AK138295 ENSMUST00000223900.1 uc288pte.1 uc288pte.2 uc288pte.1 uc288pte.2 
ENSMUST00000223901.3 Gm48433 ENSMUST00000223901.3 Gm48433 (from geneSymbol) AK028094 ENSMUST00000223901.1 ENSMUST00000223901.2 uc007ujf.1 uc007ujf.2 uc007ujf.3 uc007ujf.1 uc007ujf.2 uc007ujf.3 
ENSMUST00000223904.2 Gm46440 ENSMUST00000223904.2 Gm46440 (from geneSymbol) ENSMUST00000223904.1 uc288odh.1 uc288odh.2 uc288odh.1 uc288odh.2 
ENSMUST00000223906.2 Gm48569 ENSMUST00000223906.2 Gm48569 (from geneSymbol) AK153596 ENSMUST00000223906.1 uc288mhz.1 uc288mhz.2 uc288mhz.1 uc288mhz.2 
ENSMUST00000223907.2 Kif20b ENSMUST00000223907.2 kinesin family member 20B, transcript variant 2 (from RefSeq NM_001362434.1) E9QPW5 ENSMUST00000223907.1 KI20B_MOUSE Kif20b Mphosph1 NM_001362434 Q3V347 Q80VC0 Q80WE4 Q8BLI2 Q99PT5 uc008hgx.1 uc008hgx.2 uc008hgx.3 uc008hgx.4 Plus-end-directed motor enzyme that is required for completion of cytokinesis (By similarity). Required for proper midbody organization and abscission in polarized cortical stem cells (PubMed:24173802). Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner (PubMed:23864681). In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex (PubMed:23864681). Involved in cerebral cortex growth (PubMed:24173802). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (By similarity). Oligomerizes (via kinesin motor domain). Associates with microtubules. Interacts (via C-terminal globular tail region) with PIN1 (via WW domain). Interacts with PRC1 (By similarity). Interacts with SHTN1 (via N-terminus); the interaction is direct and promotes the association of SHTN1 to microtubules in primary neurons (PubMed:23864681). Associates with microtubules (PubMed:23864681). Nucleus Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus, nucleolus Nucleus, nucleoplasm Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Midbody ll projection, axon Cell projection, growth cone Note=Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules (By similarity). Localized to the central spindle during cytokinetic furrowing and with the midbody during abscission (PubMed:24173802). A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase. During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone. At anaphase it is concentrated in the midbody (By similarity). Colocalized partially along microtubules in primary neurons (PubMed:23864681). Colocalized with SHTN1 along microtubules to the tip of the growing cone in primary hippocampal neurons (PubMed:23864681). Localized in midbodies between dividing radial progenitors in the ventricular zone (PubMed:23864681). Colocalized with PRC1 in the nucleus of bladder carcinoma cells at the interphase. Colocalized with PRC1 in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (By similarity). Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q80WE4-1; Sequence=Displayed; Name=2; IsoId=Q80WE4-2; Sequence=VSP_022623, VSP_022626; Name=3; IsoId=Q80WE4-3; Sequence=VSP_022626; Name=4; IsoId=Q80WE4-4; Sequence=VSP_022624, VSP_022625; Expressed in the brain (at protein level) (PubMed:24173802). Expressed in the developing brain (PubMed:23864681). Expressed in the apical aspect of the ventricular zone, in the marginal zone, in a narrow stripe between the intermediate zone and the cortical plate at 14.5 dpc (PubMed:23864681). Expressed in multipolar cells at 14 dpc (at protein level) (PubMed:23864681). Expressed in neuronal stem/progenitor cells at 14.5 dpc (PubMed:24173802). Phosphorylated during mitosis by CDK1. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Sequence=AAH48954.1; Type=Frameshift; Evidence=; Sequence=AAP14646.1; Type=Frameshift; Evidence=; nucleotide binding spindle pole neural tube closure microtubule motor activity protein binding ATP binding nucleus nucleoplasm nucleolus cytoplasm centrosome microtubule organizing center spindle cytoskeleton kinesin complex microtubule microtubule-based movement cell cycle regulation of mitotic nuclear division microtubule binding positive regulation of cell proliferation ATP-dependent microtubule motor activity, plus-end-directed microtubule cytoskeleton ATPase activity axon growth cone midbody positive regulation of cytokinesis protein localization to microtubule protein homodimerization activity cell projection perinuclear region of cytoplasm neuron projection morphogenesis WW domain binding spindle midzone cell division regulation of establishment of protein localization contractile ring positive regulation of intracellular protein transport mitotic spindle pole positive regulation of mitotic cytokinetic process mitotic spindle midzone regulation of establishment of cell polarity regulation of neuron migration positive regulation of neuron migration uc008hgx.1 uc008hgx.2 uc008hgx.3 uc008hgx.4 
ENSMUST00000223912.2 Tmem267 ENSMUST00000223912.2 transmembrane protein 267, transcript variant 1 (from RefSeq NM_001039244.4) ENSMUST00000223912.1 H3BJ86 H3BJ86_MOUSE NM_001039244 Tmem267 uc288qfe.1 uc288qfe.2 Membrane ; Multi- pass membrane protein membrane integral component of membrane uc288qfe.1 uc288qfe.2 
ENSMUST00000223914.2 Gm47881 ENSMUST00000223914.2 Gm47881 (from geneSymbol) ENSMUST00000223914.1 uc288lpy.1 uc288lpy.2 uc288lpy.1 uc288lpy.2 
ENSMUST00000223923.3 1700062C10Rik ENSMUST00000223923.3 1700062C10Rik (from geneSymbol) AK006860 ENSMUST00000223923.1 ENSMUST00000223923.2 uc288qzt.1 uc288qzt.2 uc288qzt.3 uc288qzt.1 uc288qzt.2 uc288qzt.3 
ENSMUST00000223925.2 Gm48899 ENSMUST00000223925.2 Gm48899 (from geneSymbol) ENSMUST00000223925.1 uc288ofg.1 uc288ofg.2 uc288ofg.1 uc288ofg.2 
ENSMUST00000223940.2 Gm48006 ENSMUST00000223940.2 Gm48006 (from geneSymbol) ENSMUST00000223940.1 uc288rur.1 uc288rur.2 uc288rur.1 uc288rur.2 
ENSMUST00000223949.2 Parp8 ENSMUST00000223949.2 poly (ADP-ribose) polymerase family, member 8, transcript variant 4 (from RefSeq NM_001427067.1) D13Ertd275e ENSMUST00000223949.1 NM_001427067 PARP8_MOUSE Parp8 Q3UD82 Q3UDE4 Q3UDU5 Q8VCB5 Q9CYY3 uc007ryj.1 uc007ryj.2 uc007ryj.3 Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins. Reaction=L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP- D-ribosyl)-L-cysteinyl-[protein]; Xref=Rhea:RHEA:56612, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:14624, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29950, ChEBI:CHEBI:57540, ChEBI:CHEBI:140607; Evidence=; Auto-mono-ADP-ribosylated. Belongs to the ARTD/PARP family. Sequence=AAH21315.1; Type=Erroneous initiation; Evidence=; Sequence=AAH21881.1; Type=Erroneous initiation; Evidence=; NAD+ ADP-ribosyltransferase activity nuclear envelope endoplasmic reticulum protein ADP-ribosylation transferase activity transferase activity, transferring glycosyl groups kinase binding endoplasmic reticulum unfolded protein response protein serine/threonine kinase activator activity protein auto-ADP-ribosylation endoplasmic reticulum tubular network positive regulation of protein serine/threonine kinase activity protein ADP-ribosylase activity uc007ryj.1 uc007ryj.2 uc007ryj.3 
ENSMUST00000223962.2 Gm47471 ENSMUST00000223962.2 Gm47471 (from geneSymbol) AK144957 ENSMUST00000223962.1 uc289mlw.1 uc289mlw.2 uc289mlw.1 uc289mlw.2 
ENSMUST00000223966.2 Gm35387 ENSMUST00000223966.2 Gm35387 (from geneSymbol) BC066010 ENSMUST00000223966.1 uc288rve.1 uc288rve.2 uc288rve.1 uc288rve.2 
ENSMUST00000223967.2 Tcstv3 ENSMUST00000223967.2 2 cell stage variable group member 3 (from RefSeq NM_153523.3) ENSMUST00000223967.1 NM_153523 O70518 O70518_MOUSE Tcstv3 uc009shu.1 uc009shu.2 uc009shu.3 molecular_function cellular_component biological_process uc009shu.1 uc009shu.2 uc009shu.3 
ENSMUST00000223977.2 Gm48683 ENSMUST00000223977.2 Gm48683 (from geneSymbol) ENSMUST00000223977.1 uc289pxs.1 uc289pxs.2 uc289pxs.1 uc289pxs.2 
ENSMUST00000223982.2 Ptprm ENSMUST00000223982.2 protein tyrosine phosphatase receptor type M (from RefSeq NM_008984.2) E9QKU4 ENSMUST00000223982.1 Kiaa4044 NM_008984 P28828 PTPRM_MOUSE Q571L8 uc008dka.1 uc008dka.2 uc008dka.3 uc008dka.4 Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation. Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function. Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Homodimer. P28828; Q62470: Itga3; NbExp=3; IntAct=EBI-8539266, EBI-8398907; Cell membrane ; Single-pass type I membrane protein Note=Localizes in regions of cell-cell contact. Most abundant in lung, less in brain and heart. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. negative regulation of endothelial cell proliferation phosphoprotein phosphatase activity protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding cytoplasm plasma membrane cell-cell junction cell-cell adherens junction protein dephosphorylation cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules signal transduction negative regulation of endothelial cell migration retina layer formation membrane integral component of membrane dephosphorylation negative regulation of angiogenesis hydrolase activity phosphatase activity lamellipodium neuron projection development retinal ganglion cell axon guidance peptidyl-tyrosine dephosphorylation response to drug identical protein binding cadherin binding perinuclear region of cytoplasm uc008dka.1 uc008dka.2 uc008dka.3 uc008dka.4 
ENSMUST00000223988.3 Gm49398 ENSMUST00000223988.3 Gm49398 (from geneSymbol) BC099927 ENSMUST00000223988.1 ENSMUST00000223988.2 uc288nnf.1 uc288nnf.2 uc288nnf.3 uc288nnf.1 uc288nnf.2 uc288nnf.3 
ENSMUST00000223991.2 Gm38409 ENSMUST00000223991.2 predicted gene, 38409 (from RefSeq NR_153767.1) ENSMUST00000223991.1 NR_153767 uc288vhz.1 uc288vhz.2 uc288vhz.1 uc288vhz.2 
ENSMUST00000223994.2 Gm3227 ENSMUST00000223994.2 Gm3227 (from geneSymbol) AK133651 ENSMUST00000223994.1 uc008ehp.1 uc008ehp.2 uc008ehp.1 uc008ehp.2 
ENSMUST00000223995.2 Gm36101 ENSMUST00000223995.2 Gm36101 (from geneSymbol) AK076387 ENSMUST00000223995.1 uc288mqb.1 uc288mqb.2 uc288mqb.1 uc288mqb.2 
ENSMUST00000223997.2 Gm47479 ENSMUST00000223997.2 Gm47479 (from geneSymbol) ENSMUST00000223997.1 uc288qbc.1 uc288qbc.2 uc288qbc.1 uc288qbc.2 
ENSMUST00000224000.2 Gm35733 ENSMUST00000224000.2 Gm35733 (from geneSymbol) ENSMUST00000224000.1 uc288mpz.1 uc288mpz.2 uc288mpz.1 uc288mpz.2 
ENSMUST00000224001.2 Treml1 ENSMUST00000224001.2 triggering receptor expressed on myeloid cells-like 1, transcript variant 1 (from RefSeq NM_027763.2) B2RRH0 ENSMUST00000224001.1 NM_027763 Q8K558 Q9D3N6 TRML1_MOUSE Tlt1 uc008cxm.1 uc008cxm.2 uc008cxm.3 uc008cxm.4 Cell surface receptor that may play a role in the innate and adaptive immune response. When phosphorylated, interacts with PTPN11 (By similarity). When phosphorylated, interacts with PTPN6. Cell membrane ; Single-pass type I membrane protein Cytoplasm Note=Sequestered in cytoplasmic vesicles in resting platelets. Transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K558-1; Sequence=Displayed; Name=2; IsoId=Q8K558-2; Sequence=VSP_021127; Highly expressed in bone marrow leukocytes, splenic megakaryocytes and platelets. Detected in brain, liver and in peritoneal monocytes. Phosphorylated on tyrosine residues. cytoplasm plasma membrane negative regulation of signal transduction cell surface membrane integral component of membrane calcium-mediated signaling platelet activation platelet alpha granule signaling receptor activity wound healing uc008cxm.1 uc008cxm.2 uc008cxm.3 uc008cxm.4 
ENSMUST00000224003.2 Gm47558 ENSMUST00000224003.2 Gm47558 (from geneSymbol) AK036621 ENSMUST00000224003.1 uc288qbf.1 uc288qbf.2 uc288qbf.1 uc288qbf.2 
ENSMUST00000224009.2 A630019I02Rik ENSMUST00000224009.2 RIKEN cDNA A630019I02 gene (from RefSeq NR_046182.1) ENSMUST00000224009.1 NR_046182 uc029scp.1 uc029scp.2 uc029scp.1 uc029scp.2 
ENSMUST00000224012.3 3110040M04Rik ENSMUST00000224012.3 RIKEN cDNA 3110040M04 gene (from RefSeq NM_001372355.1) 3110040M04Rik A0A286YDK0 A0A286YDK0_MOUSE ENSMUST00000224012.1 ENSMUST00000224012.2 NM_001372355 uc287mmt.1 uc287mmt.2 uc287mmt.3 molecular_function cellular_component biological_process uc287mmt.1 uc287mmt.2 uc287mmt.3 
ENSMUST00000224018.2 Gm48099 ENSMUST00000224018.2 Gm48099 (from geneSymbol) ENSMUST00000224018.1 uc288rdk.1 uc288rdk.2 uc288rdk.1 uc288rdk.2 
ENSMUST00000224024.2 4921520N01Rik ENSMUST00000224024.2 4921520N01Rik (from geneSymbol) AK014933 ENSMUST00000224024.1 uc288lqb.1 uc288lqb.2 uc288lqb.1 uc288lqb.2 
ENSMUST00000224038.2 Gm47061 ENSMUST00000224038.2 Gm47061 (from geneSymbol) ENSMUST00000224038.1 LF199496 uc288mgo.1 uc288mgo.2 uc288mgo.1 uc288mgo.2 
ENSMUST00000224044.2 5430414B19Rik ENSMUST00000224044.2 5430414B19Rik (from geneSymbol) ENSMUST00000224044.1 uc288rag.1 uc288rag.2 uc288rag.1 uc288rag.2 
ENSMUST00000224047.2 Mbd1 ENSMUST00000224047.2 methyl-CpG binding domain protein 1, transcript variant 9 (from RefSeq NM_001402894.1) A0A286YDI1 A0A286YDI1_MOUSE ENSMUST00000224047.1 Mbd1 NM_001402894 uc012bex.1 uc012bex.2 uc012bex.3 Nucleus DNA binding nucleus zinc ion binding uc012bex.1 uc012bex.2 uc012bex.3 
ENSMUST00000224051.2 Gm48601 ENSMUST00000224051.2 Gm48601 (from geneSymbol) AK136545 ENSMUST00000224051.1 uc288qth.1 uc288qth.2 uc288qth.1 uc288qth.2 
ENSMUST00000224060.2 ENSMUSG00000121632 ENSMUST00000224060.2 ENSMUSG00000121632 (from geneSymbol) ENSMUST00000224060.1 uc288uyh.1 uc288uyh.2 uc288uyh.1 uc288uyh.2 
ENSMUST00000224064.2 Gm5084 ENSMUST00000224064.2 predicted gene 5084 (from RefSeq NR_036449.1) ENSMUST00000224064.1 NR_036449 uc007qvj.1 uc007qvj.2 uc007qvj.3 uc007qvj.1 uc007qvj.2 uc007qvj.3 
ENSMUST00000224071.2 Gm48438 ENSMUST00000224071.2 Gm48438 (from geneSymbol) ENSMUST00000224071.1 uc288qsn.1 uc288qsn.2 uc288qsn.1 uc288qsn.2 
ENSMUST00000224080.2 Gm48596 ENSMUST00000224080.2 Gm48596 (from geneSymbol) ENSMUST00000224080.1 uc288pnz.1 uc288pnz.2 uc288pnz.1 uc288pnz.2 
ENSMUST00000224082.2 2810403G07Rik ENSMUST00000224082.2 2810403G07Rik (from geneSymbol) AK012974 ENSMUST00000224082.1 uc288pyt.1 uc288pyt.2 uc288pyt.1 uc288pyt.2 
ENSMUST00000224095.3 Gm47547 ENSMUST00000224095.3 Gm47547 (from geneSymbol) BC019681 ENSMUST00000224095.1 ENSMUST00000224095.2 uc288sna.1 uc288sna.2 uc288sna.3 uc288sna.1 uc288sna.2 uc288sna.3 
ENSMUST00000224112.2 Prss51 ENSMUST00000224112.2 Prss51 (from geneSymbol) A0A286YDY8 A0A286YDY8_MOUSE BC048657 ENSMUST00000224112.1 Prss51 uc288vea.1 uc288vea.2 serine-type endopeptidase activity proteolysis secretory granule uc288vea.1 uc288vea.2 
ENSMUST00000224118.2 Grk6 ENSMUST00000224118.2 G protein-coupled receptor kinase 6, transcript variant 3 (from RefSeq NM_001112711.2) ENSMUST00000224118.1 GRK6_MOUSE Gprk6 NM_001112711 O70293 O70294 O70295 Q6DI67 uc011yzt.1 uc011yzt.2 uc011yzt.3 uc011yzt.4 Specifically phosphorylates the activated forms of G protein- coupled receptors. Such receptor phosphorylation initiates beta- arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro) (By similarity). Reaction=[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+); Xref=Rhea:RHEA:12008, Rhea:RHEA- COMP:11260, Rhea:RHEA-COMP:11261, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.16; Interacts with GIT1. O70293-1; Q28619: NHERF1; Xeno; NbExp=5; IntAct=EBI-7073604, EBI-7073613; Membrane; Lipid-anchor. Event=Alternative splicing; Named isoforms=2; Name=GRK6A; IsoId=O70293-1; Sequence=Displayed; Name=GRK6B; IsoId=O70293-2; Sequence=VSP_004939; Expressed in the brain in striatal neurons. Deficient mice show significant altered central dopamine receptors regulation, deficient lymphocyte chemotaxis and increased acute inflammation and neutrophil chemotaxis. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. nucleotide binding desensitization of G-protein coupled receptor protein signaling pathway protein kinase activity protein serine/threonine kinase activity G-protein coupled receptor kinase activity protein binding ATP binding cytosol plasma membrane protein phosphorylation signal transduction negative regulation of anion channel activity membrane Wnt signaling pathway kinase activity phosphorylation transferase activity beta-adrenergic receptor kinase activity uc011yzt.1 uc011yzt.2 uc011yzt.3 uc011yzt.4 
ENSMUST00000224137.3 Ppifos ENSMUST00000224137.3 peptidylprolyl isomerase F, opposite strand (from RefSeq NR_028021.1) ENSMUST00000224137.1 ENSMUST00000224137.2 NR_028021 uc007srs.1 uc007srs.2 uc007srs.3 uc007srs.4 uc007srs.5 uc007srs.1 uc007srs.2 uc007srs.3 uc007srs.4 uc007srs.5 
ENSMUST00000224142.2 Cartpt ENSMUST00000224142.2 CART prepropeptide, transcript variant 2 (from RefSeq NM_001081493.2) Cart Cartpt ENSMUST00000224142.1 NM_001081493 Q3UYI4 Q3UYI4_MOUSE uc007rpx.1 uc007rpx.2 uc007rpx.3 uc007rpx.4 This gene encodes preproprotein isoforms that are processed into multiple biologically active peptides. Expression of this gene is regulated by cocaine and other drugs, and is associated with feeding/appetite and stress response. Mice lacking the encoded protein are predisposed to obesity. Deficiency of the encoded protein in mice results in pancreatic islet dysfunction, impaired insulin secretion and glucose intolerance. Alternative splicing results in multiple transcript variants encoding different isoforms, which are subsequently processed into mature peptides. [provided by RefSeq, Jul 2015]. Secreted Belongs to the CART family. activation of MAPKK activity neuropeptide hormone activity extracellular space G-protein coupled receptor signaling pathway adult feeding behavior cellular response to starvation negative regulation of appetite uc007rpx.1 uc007rpx.2 uc007rpx.3 uc007rpx.4 
ENSMUST00000224146.2 Gm4814 ENSMUST00000224146.2 predicted gene 4814 (from RefSeq NR_036451.1) ENSMUST00000224146.1 NR_036451 uc011zcu.1 uc011zcu.2 uc011zcu.3 uc011zcu.4 uc011zcu.5 uc011zcu.1 uc011zcu.2 uc011zcu.3 uc011zcu.4 uc011zcu.5 
ENSMUST00000224163.2 Il3ra ENSMUST00000224163.2 Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (By similarity). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation (PubMed:10477686, PubMed:31990690). Activation of JAK2 leads to STAT5-mediated transcriptional program (PubMed:10376805). (from UniProt P26952) B9VI80 BC049889 ENSMUST00000224163.1 IL3RA_MOUSE P26952 Sut-1 uc288qxg.1 uc288qxg.2 Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (By similarity). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation (PubMed:10477686, PubMed:31990690). Activation of JAK2 leads to STAT5-mediated transcriptional program (PubMed:10376805). Interacts with IL3. Heterodimer of an alpha and a beta subunit (PubMed:10477686). The beta subunit is common to the IL3, IL5 and GM- CSF receptors. [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=Expressed on the cell surface. [Isoform 2]: Endomembrane system; Single-pass type I membrane protein. Note=Mostly distributed inside the cells, except in the nuclei and is not transported to the cell surface. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=B, SP1; IsoId=P26952-1; Sequence=Displayed; Name=2; Synonyms=SP2; IsoId=P26952-3; Sequence=VSP_040623; Name=3; Synonyms=A; IsoId=P26952-2; Sequence=VSP_011265; The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Ubiquitinated at Lys-357 by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome. Belongs to the type I cytokine receptor family. Type 5 subfamily. regulation of cell growth cytokine receptor activity interleukin-3 receptor activity plasma membrane external side of plasma membrane endomembrane system membrane integral component of membrane cytokine-mediated signaling pathway cytokine binding interleukin-3 binding monocyte differentiation cellular response to interleukin-3 interleukin-3-mediated signaling pathway receptor complex uc288qxg.1 uc288qxg.2 
ENSMUST00000224181.2 Gm47797 ENSMUST00000224181.2 Gm47797 (from geneSymbol) ENSMUST00000224181.1 uc288rah.1 uc288rah.2 uc288rah.1 uc288rah.2 
ENSMUST00000224212.2 Gm47913 ENSMUST00000224212.2 Gm47913 (from geneSymbol) ENSMUST00000224212.1 uc288qdg.1 uc288qdg.2 uc288qdg.1 uc288qdg.2 
ENSMUST00000224213.2 Gm48763 ENSMUST00000224213.2 Gm48763 (from geneSymbol) BC120876 ENSMUST00000224213.1 uc288map.1 uc288map.2 uc288map.1 uc288map.2 
ENSMUST00000224216.2 Gm32243 ENSMUST00000224216.2 Gm32243 (from geneSymbol) ENSMUST00000224216.1 uc288mfp.1 uc288mfp.2 uc288mfp.1 uc288mfp.2 
ENSMUST00000224226.3 4930469K13Rik ENSMUST00000224226.3 4930469K13Rik (from geneSymbol) 4930469K13Rik A0A286YDX3 A0A286YDX3_MOUSE AK015529 ENSMUST00000224226.1 ENSMUST00000224226.2 uc287xjh.1 uc287xjh.2 uc287xjh.3 uc287xjh.1 uc287xjh.2 uc287xjh.3 
ENSMUST00000224246.2 Gm49350 ENSMUST00000224246.2 Gm49350 (from geneSymbol) ENSMUST00000224246.1 uc288mcn.1 uc288mcn.2 uc288mcn.1 uc288mcn.2 
ENSMUST00000224264.2 Gm48370 ENSMUST00000224264.2 Gm48370 (from geneSymbol) ENSMUST00000224264.1 uc288qse.1 uc288qse.2 uc288qse.1 uc288qse.2 
ENSMUST00000224270.2 Gm48090 ENSMUST00000224270.2 Gm48090 (from geneSymbol) AK077132 ENSMUST00000224270.1 uc288pjh.1 uc288pjh.2 uc288pjh.1 uc288pjh.2 
ENSMUST00000224272.2 Eml3 ENSMUST00000224272.2 echinoderm microtubule associated protein like 3, transcript variant 2 (from RefSeq NM_001374671.1) A0A286YDN1 A0A286YDN1_MOUSE ENSMUST00000224272.1 Eml3 NM_001374671 uc008goe.1 uc008goe.2 uc008goe.3 Cytoplasm, cytoskeleton uc008goe.1 uc008goe.2 uc008goe.3 
ENSMUST00000224277.2 Percc1 ENSMUST00000224277.2 proline and glutamate rich with coiled coil 1, transcript variant 2 (from RefSeq NM_001370860.1) A0A286YDK6 ENSMUST00000224277.1 Gm38655 NM_001370860 PERC1_MOUSE Percc1 uc289ihm.1 uc289ihm.2 Plays a critical role in intestinal function by promoting the development of enteroendocrine cells (EECs) of the gastrointestinal tract and pancreas (PubMed:31217582). It is thereby required for normal enteroendocrine peptide hormone secretion (PubMed:31217582). Specifically expressed in the stomach, pancreas and intestine (PubMed:31217582). In gastrointestinal tissue, expression is primarily restricted to gastric G cells and duodenal enteroendocrine cells (EECs) (PubMed:31217582). Mice were born at the expected Mendelian frequency and do not show gross phenotypes at birth (PubMed:31217582). within the first days of life, mice however display reduced size, low body weight and substantially decreased survival (PubMed:31217582). Examination of fecal pellets and internal organs reveal abnormal digestive-tract function, as well as changes in the composition of the intestinal microbiome (PubMed:31217582). Defects are caused by impaired expression of gastrointestinal peptide hormones and development of enteroendocrine cells (EECs) (PubMed:31217582). uc289ihm.1 uc289ihm.2 
ENSMUST00000224300.2 Lysmd3 ENSMUST00000224300.2 LysM, putative peptidoglycan-binding, domain containing 3 (from RefSeq NM_030257.1) ENSMUST00000224300.1 LYSM3_MOUSE NM_030257 Q99LE3 uc007rhw.1 uc007rhw.2 uc007rhw.3 uc007rhw.4 Essential for Golgi structural integrity. Cell membrane ; Single-pass membrane protein Golgi apparatus molecular_function cellular_component biological_process membrane integral component of membrane uc007rhw.1 uc007rhw.2 uc007rhw.3 uc007rhw.4 
ENSMUST00000224316.2 Gm48857 ENSMUST00000224316.2 Gm48857 (from geneSymbol) ENSMUST00000224316.1 uc288qwy.1 uc288qwy.2 uc288qwy.1 uc288qwy.2 
ENSMUST00000224330.2 Gm8947 ENSMUST00000224330.2 Gm8947 (from geneSymbol) A0A286YD13 A0A286YD13_MOUSE ENSMUST00000224330.1 Gm8947 uc287mmr.1 uc287mmr.2 molecular_function cellular_component biological_process uc287mmr.1 uc287mmr.2 
ENSMUST00000224331.2 Hesx1 ENSMUST00000224331.2 homeobox gene expressed in ES cells, transcript variant 2 (from RefSeq NM_001424469.1) ENSMUST00000224331.1 HESX1_MOUSE Hes-1 NM_001424469 Q61047 Q61658 Q8C477 Rpx uc288rsu.1 uc288rsu.2 Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation. Can form heterodimers with PROP1 in binding to DNA Interacts with TLE1. Nucleus High levels found in the embryonic liver, lower level expression seen in the viscera, amnion and yolk sac. Early expression seen in the anterior midline endoderm and prechordal plate precursor, subsequently activated in the overlying ectoderm of the cephalic neural plate. Later disappears in the mesendoderm while remaining in the prospective prosencephalic region of the neural plate ectoderm, ultimately expression is restricted to Rathke pouch, the primordium of the pituitary. Expressed in embryonic stem cells. Down-regulated during embryonic stem (ES) cell differentiation. Belongs to the ANF homeobox family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding protein binding nucleus regulation of transcription, DNA-templated multicellular organism development brain development protein C-terminus binding transcription factor binding pituitary gland development otic vesicle formation sequence-specific DNA binding nose development negative regulation of transcription, DNA-templated protein N-terminus binding forebrain morphogenesis uc288rsu.1 uc288rsu.2 
ENSMUST00000224352.3 Gm48003 ENSMUST00000224352.3 Gm48003 (from geneSymbol) ENSMUST00000224352.1 ENSMUST00000224352.2 uc288ruv.1 uc288ruv.2 uc288ruv.3 uc288ruv.1 uc288ruv.2 uc288ruv.3 
ENSMUST00000224359.2 H2bc9 ENSMUST00000224359.2 H2B clustered histone 9 (from RefSeq NM_178197.2) A2RTP6 ENSMUST00000224359.1 H2B1H_MOUSE H2bc9 Hist1h2bh NM_178197 Q3TYR6 Q64478 uc007pty.1 uc007pty.2 uc007pty.3 uc007pty.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome DNA binding nucleus nucleoplasm chromosome nucleosome assembly protein heterodimerization activity uc007pty.1 uc007pty.2 uc007pty.3 uc007pty.4 
ENSMUST00000224384.2 Gm34245 ENSMUST00000224384.2 predicted gene, 34245 (from RefSeq NR_169307.1) ENSMUST00000224384.1 NR_169307 uc288nht.1 uc288nht.2 uc288nht.1 uc288nht.2 
ENSMUST00000224386.2 Skic3 ENSMUST00000224386.2 SKI3 subunit of superkiller complex, transcript variant 4 (from RefSeq NM_001426642.1) ENSMUST00000224386.1 F8VPK0 NM_001426642 SKI3_MOUSE Skic3 uc007rgl.1 uc007rgl.2 uc007rgl.3 Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality- control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). Component of the SKI complex which consists of SKIC2, SKIC3 and SKIC8. Interacts with PAF1. Cytoplasm Nucleus Belongs to the SKI3 family. molecular_function nucleus nucleoplasm cytoplasm cytosol RNA catabolic process biological_process transcriptionally active chromatin Ski complex uc007rgl.1 uc007rgl.2 uc007rgl.3 
ENSMUST00000224393.2 Gm48837 ENSMUST00000224393.2 Gm48837 (from geneSymbol) AK076561 ENSMUST00000224393.1 uc288pys.1 uc288pys.2 uc288pys.1 uc288pys.2 
ENSMUST00000224401.2 5430425E15Rik ENSMUST00000224401.2 5430425E15Rik (from geneSymbol) AK017335 ENSMUST00000224401.1 uc288rnf.1 uc288rnf.2 uc288rnf.1 uc288rnf.2 
ENSMUST00000224413.3 Gm3509 ENSMUST00000224413.3 predicted gene 3509 (from RefSeq NR_188836.1) ENSMUST00000224413.1 ENSMUST00000224413.2 NR_188836 uc288mfl.1 uc288mfl.2 uc288mfl.3 uc288mfl.1 uc288mfl.2 uc288mfl.3 
ENSMUST00000224417.2 Gm32063 ENSMUST00000224417.2 Gm32063 (from geneSymbol) ENSMUST00000224417.1 uc288mhr.1 uc288mhr.2 uc288mhr.1 uc288mhr.2 
ENSMUST00000224418.2 Gm48162 ENSMUST00000224418.2 Gm48162 (from geneSymbol) ENSMUST00000224418.1 uc288rax.1 uc288rax.2 uc288rax.1 uc288rax.2 
ENSMUST00000224419.2 Gm48696 ENSMUST00000224419.2 Gm48696 (from geneSymbol) ENSMUST00000224419.1 uc289pxo.1 uc289pxo.2 uc289pxo.1 uc289pxo.2 
ENSMUST00000224432.2 Dsc1 ENSMUST00000224432.2 desmocollin 1, transcript variant 1 (from RefSeq NM_001291804.1) DSC1_MOUSE E9QJX2 ENSMUST00000224432.1 NM_001291804 P55849 uc008eeh.1 uc008eeh.2 uc008eeh.3 uc008eeh.4 uc008eeh.5 This gene encodes a member of the cadherin family of proteins that mediates adhesion in desmosomes. The encoded preproprotein undergoes proteolytic processing to generate the mature, functional protein. Mice lacking the encoded protein exhibit epidermal fragility together with defects of epidermal barrier and differentiation. The neonatal mice lacking the encoded protein exhibit epidermal lesions and older mice develop chronic dermatitis. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]. Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. Binds to JUP/plakoglobin. Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. Event=Alternative splicing; Named isoforms=2; Name=1A; IsoId=P55849-1; Sequence=Displayed; Name=1B; IsoId=P55849-2; Sequence=VSP_000653, VSP_000654; Calcium may be bound by the cadherin-like repeats. calcium ion binding protein binding plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane cell junction desmosome cell-cell adhesion uc008eeh.1 uc008eeh.2 uc008eeh.3 uc008eeh.4 uc008eeh.5 
ENSMUST00000224435.2 Mnd1-ps ENSMUST00000224435.2 Mnd1 retrotransposed pseudogene (from RefSeq NR_030680.1) ENSMUST00000224435.1 NR_030680 uc011zfy.1 uc011zfy.2 uc011zfy.3 uc011zfy.1 uc011zfy.2 uc011zfy.3 
ENSMUST00000224437.3 ENSMUSG00000121771 ENSMUST00000224437.3 ENSMUSG00000121771 (from geneSymbol) AK132930 ENSMUST00000224437.1 ENSMUST00000224437.2 uc288ley.1 uc288ley.2 uc288ley.3 uc288ley.1 uc288ley.2 uc288ley.3 
ENSMUST00000224440.2 Gm32401 ENSMUST00000224440.2 Gm32401 (from geneSymbol) AK080039 ENSMUST00000224440.1 uc288mia.1 uc288mia.2 uc288mia.1 uc288mia.2 
ENSMUST00000224451.2 2010001K21Rik ENSMUST00000224451.2 2010001K21Rik (from geneSymbol) AK053225 ENSMUST00000224451.1 uc288mpc.1 uc288mpc.2 uc288mpc.1 uc288mpc.2 
ENSMUST00000224459.2 Gm48767 ENSMUST00000224459.2 Gm48767 (from geneSymbol) ENSMUST00000224459.1 uc288mas.1 uc288mas.2 uc288mas.1 uc288mas.2 
ENSMUST00000224467.3 Fbxo15 ENSMUST00000224467.3 F-box protein 15, transcript variant 1 (from RefSeq NM_015798.5) A0A286YDM4 A0A286YDM4_MOUSE ENSMUST00000224467.1 ENSMUST00000224467.2 Fbxo15 NM_015798 uc008fux.1 uc008fux.2 uc008fux.3 uc008fux.4 uc008fux.1 uc008fux.2 uc008fux.3 uc008fux.4 
ENSMUST00000224471.2 Gm31834 ENSMUST00000224471.2 Gm31834 (from geneSymbol) ENSMUST00000224471.1 uc288mej.1 uc288mej.2 uc288mej.1 uc288mej.2 
ENSMUST00000224473.2 Gm47675 ENSMUST00000224473.2 Gm47675 (from geneSymbol) ENSMUST00000224473.1 uc288mbf.1 uc288mbf.2 uc288mbf.1 uc288mbf.2 
ENSMUST00000224482.2 Gm47511 ENSMUST00000224482.2 Gm47511 (from geneSymbol) ENSMUST00000224482.1 uc288met.1 uc288met.2 uc288met.1 uc288met.2 
ENSMUST00000224491.2 Nek10 ENSMUST00000224491.2 NIMA (never in mitosis gene a)- related kinase 10, transcript variant 2 (from RefSeq NM_001394992.1) ENSMUST00000224491.1 K3W4R8 K3W4R8_MOUSE NM_001394992 Nek10 uc288qyp.1 uc288qyp.2 Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. protein kinase activity ATP binding protein phosphorylation uc288qyp.1 uc288qyp.2 
ENSMUST00000224494.3 Gm47798 ENSMUST00000224494.3 Gm47798 (from geneSymbol) ENSMUST00000224494.1 ENSMUST00000224494.2 uc288raj.1 uc288raj.2 uc288raj.1 uc288raj.2 
ENSMUST00000224497.2 Ddx11 ENSMUST00000224497.2 DEAD/H box helicase 11, transcript variant 2 (from RefSeq NM_001348292.1) A0A286YDJ5 DDX11_MOUSE Ddx11 ENSMUST00000224497.1 NM_001348292 Q6AXC6 uc008dhb.1 uc008dhb.2 uc008dhb.3 DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis. Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities. Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G- quadruplex and three-stranded D-loop DNA molecules. Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage. Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (By similarity). Cooperates also with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17611414). Stimulates 5'-single- stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis. Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non- coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (By similarity). Plays also a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (By similarity). Plays a role in embryonic development and prevention of aneuploidy (PubMed:17611414). Involved in melanoma cell proliferation and survival. Associates with chromatin at DNA replication fork regions. Binds to single- and double- stranded DNAs (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. ; Associates with the CTF18-RFC complex. Associates with a cohesin complex composed of RAD21, SMC1 proteins and SMC3. Interacts with CHTF18. Interacts with DSCC1. Interacts with FEN1; this interaction is direct and increases flap endonuclease activity of FEN1. Interacts with PCNA. Interacts with POLR1A and UBTF. Interacts with RAD21, SMC1 proteins and SMC3. Interacts with RFC2. Interacts with TIMELESS; this interaction increases recruitment of both proteins onto chromatin in response to replication stress induction by hydroxyurea. Nucleus Nucleus, nucleolus Cytoplasm, cytoskeleton, spindle pole Midbody Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=During the early stages of mitosis, localizes to condensed chromatin and is released from the chromatin with progression to metaphase. Also localizes to the spindle poles throughout mitosis and at the midbody at later stages of mitosis (metaphase to telophase). In interphase, colocalizes with nucleolin in the nucleolus. Embryonic death at 10.5 dpc (PubMed:17611414). Embryos are smaller in size, malformed and exhibit sparse cellularity in comparison to normal or heterozygous litter mates (PubMed:17611414). Show inability to form a proper embryonic placenta. Display high incidence of cell aneuploidy due to abnormal chromosomal segregation (PubMed:17611414). Show abnormal formation and localization of heterochromatin (PubMed:21854770). Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily. Sequence=AAH79656.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; nucleotide binding nuclear chromatin spindle pole fibrillar center nucleic acid binding DNA binding DNA helicase activity chromatin binding DNA replication origin binding double-stranded DNA binding single-stranded DNA binding RNA binding single-stranded RNA binding helicase activity ATP binding nucleus nucleolus cytoplasm centrosome microtubule organizing center cytoskeleton nucleobase-containing compound metabolic process DNA replication DNA repair cellular response to DNA damage stimulus sister chromatid cohesion multicellular organism development DNA-dependent ATPase activity RNA-dependent ATPase activity hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides midbody replication fork processing positive regulation of endodeoxyribonuclease activity negative regulation of protein binding DNA duplex unwinding establishment of sister chromatid cohesion positive regulation of chromatin binding G-quadruplex DNA unwinding triplex DNA binding positive regulation of sister chromatid cohesion metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding G-quadruplex DNA binding extracellular exosome cellular response to hydroxyurea cellular response to cisplatin positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter cellular response to bleomycin nucleolar chromatin organization positive regulation of double-strand break repair Ctf18 RFC-like complex mitotic cohesin complex uc008dhb.1 uc008dhb.2 uc008dhb.3 
ENSMUST00000224503.2 Kif13b ENSMUST00000224503.2 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (from UniProt A0A286YCV9) A0A286YCV9 A0A286YCV9_MOUSE AK172989 ENSMUST00000224503.1 Kif13b uc007uin.1 uc007uin.2 uc007uin.3 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding motor activity microtubule motor activity ATP binding cytoplasm cytosol kinesin complex microtubule microvillus microtubule-based movement microtubule binding ATPase activity protein kinase binding axon paranode region of axon regulation of axonogenesis 14-3-3 protein binding uc007uin.1 uc007uin.2 uc007uin.3 
ENSMUST00000224519.2 A930002C04Rik ENSMUST00000224519.2 RIKEN cDNA A930002C04 gene (from RefSeq NR_126083.1) ENSMUST00000224519.1 NR_126083 uc007qhy.1 uc007qhy.2 uc007qhy.3 uc007qhy.4 uc007qhy.1 uc007qhy.2 uc007qhy.3 uc007qhy.4 
ENSMUST00000224527.2 Gm30489 ENSMUST00000224527.2 Gm30489 (from geneSymbol) AK039288 ENSMUST00000224527.1 uc288mbh.1 uc288mbh.2 uc288mbh.1 uc288mbh.2 
ENSMUST00000224534.2 Gapt ENSMUST00000224534.2 Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells. (from UniProt Q8CB93) AK155882 ENSMUST00000224534.1 GAPT_MOUSE Q8CB93 uc033gnf.1 uc033gnf.2 uc033gnf.3 Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells. Interacts with GRB2. Cell membrane ; Single-pass membrane protein Expressed primarily in B220+ splenocytes and total bone marrow cells. Expressed at lower levels in mast cells and dendritic cells. Not detected in T-cells and macrophages (at protein level). Mice are normal in appearance, size and fertility. In aged mice, the number of MZ B-cells is increased, and serum concentrations of IgM, IgG2b, and IgG3 are elevated. Belongs to the GAPT family. B cell homeostasis B cell proliferation involved in immune response immunoglobulin production involved in immunoglobulin mediated immune response plasma membrane membrane integral component of membrane B cell activation uc033gnf.1 uc033gnf.2 uc033gnf.3 
ENSMUST00000224536.3 Gm9465 ENSMUST00000224536.3 Gm9465 (from geneSymbol) ENSMUST00000224536.1 ENSMUST00000224536.2 uc288pku.1 uc288pku.2 uc288pku.3 uc288pku.1 uc288pku.2 uc288pku.3 
ENSMUST00000224543.2 Gm48595 ENSMUST00000224543.2 Gm48595 (from geneSymbol) ENSMUST00000224543.1 uc288qtd.1 uc288qtd.2 uc288qtd.1 uc288qtd.2 
ENSMUST00000224546.2 Gm48283 ENSMUST00000224546.2 Gm48283 (from geneSymbol) AK033311 ENSMUST00000224546.1 uc288rek.1 uc288rek.2 uc288rek.1 uc288rek.2 
ENSMUST00000224552.2 4930435F18Rik ENSMUST00000224552.2 RIKEN cDNA 4930435F18 gene (from RefSeq NR_153406.1) ENSMUST00000224552.1 NR_153406 uc288qdj.1 uc288qdj.2 uc288qdj.1 uc288qdj.2 
ENSMUST00000224567.2 Gm48050 ENSMUST00000224567.2 Gm48050 (from geneSymbol) ENSMUST00000224567.1 uc288pkr.1 uc288pkr.2 uc288pkr.1 uc288pkr.2 
ENSMUST00000224579.3 Gm47711 ENSMUST00000224579.3 Gm47711 (from geneSymbol) ENSMUST00000224579.1 ENSMUST00000224579.2 uc288mbm.1 uc288mbm.2 uc288mbm.3 uc288mbm.1 uc288mbm.2 uc288mbm.3 
ENSMUST00000224584.2 Gm47827 ENSMUST00000224584.2 Gm47827 (from geneSymbol) ENSMUST00000224584.1 uc288pzn.1 uc288pzn.2 uc288pzn.1 uc288pzn.2 
ENSMUST00000224589.3 4921522A10Rik ENSMUST00000224589.3 4921522A10Rik (from geneSymbol) AK014941 ENSMUST00000224589.1 ENSMUST00000224589.2 uc288qyy.1 uc288qyy.2 uc288qyy.3 uc288qyy.1 uc288qyy.2 uc288qyy.3 
ENSMUST00000224596.2 Cc2d2b ENSMUST00000224596.2 coiled-coil and C2 domain containing 2B (from RefSeq NM_001376940.1) A0A286YDU8 A0A286YDU8_MOUSE Cc2d2b ENSMUST00000224596.1 NM_001376940 uc289ryt.1 uc289ryt.2 molecular_function cellular_component biological_process uc289ryt.1 uc289ryt.2 
ENSMUST00000224604.2 Gm31219 ENSMUST00000224604.2 Gm31219 (from geneSymbol) AK136039 ENSMUST00000224604.1 uc007rgm.1 uc007rgm.2 uc007rgm.1 uc007rgm.2 
ENSMUST00000224606.2 Gm31577 ENSMUST00000224606.2 Gm31577 (from geneSymbol) ENSMUST00000224606.1 uc288qzh.1 uc288qzh.2 uc288qzh.1 uc288qzh.2 
ENSMUST00000224614.2 Gm47067 ENSMUST00000224614.2 Gm47067 (from geneSymbol) ENSMUST00000224614.1 uc288mgq.1 uc288mgq.2 uc288mgq.1 uc288mgq.2 
ENSMUST00000224624.2 Gm46411 ENSMUST00000224624.2 Gm46411 (from geneSymbol) ENSMUST00000224624.1 uc288mct.1 uc288mct.2 uc288mct.1 uc288mct.2 
ENSMUST00000224625.2 Fdft1 ENSMUST00000224625.2 farnesyl diphosphate farnesyl transferase 1, transcript variant 2 (from RefSeq NM_010191.3) ENSMUST00000224625.1 Erg9 FDFT_MOUSE NM_010191 P53798 Q8BPF5 uc007uhj.1 uc007uhj.2 uc007uhj.3 uc007uhj.4 uc007uhj.5 Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene (PubMed:10521476). Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway (By similarity). Reaction=2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH = 2 diphosphate + NADP(+) + squalene; Xref=Rhea:RHEA:32295, ChEBI:CHEBI:15378, ChEBI:CHEBI:15440, ChEBI:CHEBI:33019, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:175763; EC=2.5.1.21; Evidence=; Reaction=2 (2E,6E)-farnesyl diphosphate + H(+) + NADH = 2 diphosphate + NAD(+) + squalene; Xref=Rhea:RHEA:32299, ChEBI:CHEBI:15378, ChEBI:CHEBI:15440, ChEBI:CHEBI:33019, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:175763; EC=2.5.1.21; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32300; Evidence=; Reaction=H(+) + NADH + presqualene diphosphate = diphosphate + NAD(+) + squalene; Xref=Rhea:RHEA:22228, ChEBI:CHEBI:15378, ChEBI:CHEBI:15440, ChEBI:CHEBI:33019, ChEBI:CHEBI:57310, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22229; Evidence=; Reaction=H(+) + NADPH + presqualene diphosphate = diphosphate + NADP(+) + squalene; Xref=Rhea:RHEA:22232, ChEBI:CHEBI:15378, ChEBI:CHEBI:15440, ChEBI:CHEBI:33019, ChEBI:CHEBI:57310, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22233; Evidence=; Reaction=2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate; Xref=Rhea:RHEA:22672, ChEBI:CHEBI:33019, ChEBI:CHEBI:57310, ChEBI:CHEBI:175763; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22673; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3. Endoplasmic reticulum membrane ; Multi-pass membrane protein Deficient mice are embryonic lethal around midgestation (9.5-10.5 dpc). Embryos exhibit severe growth retardation and defective neural tube closure. Belongs to the phytoene/squalene synthase family. catalytic activity farnesyl-diphosphate farnesyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process ergosterol biosynthetic process metabolic process steroid metabolic process cholesterol metabolic process isoprenoid biosynthetic process lipid biosynthetic process biosynthetic process membrane integral component of membrane sterol biosynthetic process transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups intracellular membrane-bounded organelle farnesyl diphosphate metabolic process squalene synthase activity uc007uhj.1 uc007uhj.2 uc007uhj.3 uc007uhj.4 uc007uhj.5 
ENSMUST00000224629.2 Fbxo16 ENSMUST00000224629.2 F-box protein 16, transcript variant 1 (from RefSeq NM_015795.2) ENSMUST00000224629.1 FBX16_MOUSE Fbx16 NM_015795 Q3TP74 Q8C5V6 Q9QZM9 uc007ujd.1 uc007ujd.2 uc007ujd.3 Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. molecular_function cellular_component biological_process uc007ujd.1 uc007ujd.2 uc007ujd.3 
ENSMUST00000224637.2 Gm10403 ENSMUST00000224637.2 Gm10403 (from geneSymbol) AK134775 ENSMUST00000224637.1 uc288qzk.1 uc288qzk.2 uc288qzk.1 uc288qzk.2 
ENSMUST00000224644.2 Gm47400 ENSMUST00000224644.2 Gm47400 (from geneSymbol) ENSMUST00000224644.1 uc288men.1 uc288men.2 uc288men.1 uc288men.2 
ENSMUST00000224647.2 F830210D05Rik ENSMUST00000224647.2 F830210D05Rik (from geneSymbol) ENSMUST00000224647.1 uc288owg.1 uc288owg.2 uc288owg.1 uc288owg.2 
ENSMUST00000224651.2 H2bc14 ENSMUST00000224651.2 H2B clustered histone 14 (from RefSeq NM_178200.2) ENSMUST00000224651.1 H2B1M_MOUSE H2bc14 Hist1h2bm NM_178200 P10854 Q5T008 uc007prd.1 uc007prd.2 uc007prd.3 uc007prd.4 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC139381.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Nucleus. Chromosome. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:15197225, PubMed:16039583). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination (PubMed:15197225). Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (PubMed:20647423, PubMed:32822587). GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Hydroxybutyrylation of histones is induced by starvation. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Belongs to the histone H2B family. nucleosome DNA binding nucleus nucleoplasm chromosome cytosol nucleosome assembly protein heterodimerization activity uc007prd.1 uc007prd.2 uc007prd.3 uc007prd.4 
ENSMUST00000224654.2 Gm38397 ENSMUST00000224654.2 predicted gene, 38397 (from RefSeq NR_131193.1) ENSMUST00000224654.1 NR_131193 uc056yve.1 uc056yve.2 uc056yve.1 uc056yve.2 
ENSMUST00000224662.2 Rnf180 ENSMUST00000224662.2 ring finger protein 180, transcript variant 3 (from RefSeq NM_001360891.1) ENSMUST00000224662.1 NM_001360891 Q3U827 Q3UW39 Q80ZX1 Q8CCR1 Q9CXV6 RN180_MOUSE Rines uc007rtr.1 uc007rtr.2 uc007rtr.3 E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Protein modification; protein ubiquitination. Interacts with ZIC2. Endoplasmic reticulum membrane ; Single-pass membrane protein Nucleus envelope Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3U827-1; Sequence=Displayed; Name=2; IsoId=Q3U827-2; Sequence=VSP_021741; Name=3; IsoId=Q3U827-3; Sequence=VSP_021743; Name=4; IsoId=Q3U827-4; Sequence=VSP_021741, VSP_021742; brain, kidney, testis and uterus. membrane protein. Nucleus envelope. Detected in the ventricular zone of the lateral ventricle in brain from 13.5 dpc and 17.5 dpc embryos. The RING-type zinc finger domain mediates polyubiquitination of the interacting protein. protein polyubiquitination protein binding nucleus nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane protein ubiquitination transferase activity adult behavior intrinsic component of endoplasmic reticulum membrane positive regulation of protein ubiquitination ubiquitin conjugating enzyme binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process norepinephrine metabolic process serotonin metabolic process metal ion binding regulation of catalytic activity ubiquitin protein ligase activity organic cyclic compound metabolic process uc007rtr.1 uc007rtr.2 uc007rtr.3 
ENSMUST00000224664.3 9430065F17Rik ENSMUST00000224664.3 9430065F17Rik (from geneSymbol) AK021377 ENSMUST00000224664.1 ENSMUST00000224664.2 uc288ofu.1 uc288ofu.2 uc288ofu.3 uc288ofu.1 uc288ofu.2 uc288ofu.3 
ENSMUST00000224666.2 Gm47921 ENSMUST00000224666.2 Gm47921 (from geneSymbol) ENSMUST00000224666.1 uc288rpf.1 uc288rpf.2 uc288rpf.1 uc288rpf.2 
ENSMUST00000224691.3 Cirop ENSMUST00000224691.3 ciliated left-right organizer metallopeptidase (from RefSeq NM_001370892.2) A0A286YEC0 CIROP_MOUSE Cirop ENSMUST00000224691.1 ENSMUST00000224691.2 Gm29776 NM_001370892 uc288uhu.1 uc288uhu.2 Putative metalloproteinase that plays a role in left-right patterning process. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Membrane ; Single-pass type I membrane protein Specifically expressed in ciliated left-right organizer. Strong levels in the ventral node from the early bud to the four-somite stage. Expression is enriched in the perinodal crown cells and become asymmetric at the three-somite stage. Belongs to the peptidase M8 family. metalloendopeptidase activity cytoplasm proteolysis cell adhesion peptidase activity membrane integral component of membrane uc288uhu.1 uc288uhu.2 
ENSMUST00000224713.2 Anxa2r1 ENSMUST00000224713.2 annexin A2 receptor 1 (from RefSeq NM_001302966.1) Anxa2r1 Anxa2r2 ENSMUST00000224713.1 NM_001302966 Q3T9V6 Q3T9V6_MOUSE uc029sds.1 uc029sds.2 uc029sds.3 uc029sds.4 signaling receptor activity uc029sds.1 uc029sds.2 uc029sds.3 uc029sds.4 
ENSMUST00000224716.2 F530104D19Rik ENSMUST00000224716.2 F530104D19Rik (from geneSymbol) AK144011 ENSMUST00000224716.1 uc008hhl.1 uc008hhl.2 uc008hhl.1 uc008hhl.2 
ENSMUST00000224720.3 Gm48570 ENSMUST00000224720.3 Gm48570 (from geneSymbol) ENSMUST00000224720.1 ENSMUST00000224720.2 uc288mhw.1 uc288mhw.2 uc288mhw.3 uc288mhw.1 uc288mhw.2 uc288mhw.3 
ENSMUST00000224731.5 A330084C13Rik ENSMUST00000224731.5 A330084C13Rik (from geneSymbol) AK039675 ENSMUST00000224731.1 ENSMUST00000224731.2 ENSMUST00000224731.3 ENSMUST00000224731.4 uc289pjc.1 uc289pjc.2 uc289pjc.3 uc289pjc.4 uc289pjc.5 uc289pjc.1 uc289pjc.2 uc289pjc.3 uc289pjc.4 uc289pjc.5 
ENSMUST00000224744.2 Gm49223 ENSMUST00000224744.2 Gm49223 (from geneSymbol) ENSMUST00000224744.1 uc288oye.1 uc288oye.2 uc288oye.1 uc288oye.2 
ENSMUST00000224745.2 Gm48708 ENSMUST00000224745.2 Gm48708 (from geneSymbol) AK132718 ENSMUST00000224745.1 uc288lzr.1 uc288lzr.2 uc288lzr.1 uc288lzr.2 
ENSMUST00000224746.2 Gm48612 ENSMUST00000224746.2 Gm48612 (from geneSymbol) ENSMUST00000224746.1 uc288mpy.1 uc288mpy.2 uc288mpy.1 uc288mpy.2 
ENSMUST00000224753.2 Gm48155 ENSMUST00000224753.2 Gm48155 (from geneSymbol) ENSMUST00000224753.1 uc288owi.1 uc288owi.2 uc288owi.1 uc288owi.2 
ENSMUST00000224757.3 Gm47996 ENSMUST00000224757.3 Gm47996 (from geneSymbol) A0A286YE43 A0A286YE43_MOUSE ENSMUST00000224757.1 ENSMUST00000224757.2 Gm47996 uc287mmu.1 uc287mmu.2 uc287mmu.3 uc287mmu.1 uc287mmu.2 uc287mmu.3 
ENSMUST00000224761.2 Gm40975 ENSMUST00000224761.2 Gm40975 (from geneSymbol) ENSMUST00000224761.1 uc288nna.1 uc288nna.2 uc288nna.1 uc288nna.2 
ENSMUST00000224763.2 Cts8-ps ENSMUST00000224763.2 cathepsin 8, pseudogene (from RefSeq NR_027871.2) ENSMUST00000224763.1 NR_027871 uc007qwh.1 uc007qwh.2 uc007qwh.1 uc007qwh.2 
ENSMUST00000224766.2 0710001A04Rik ENSMUST00000224766.2 0710001A04Rik (from geneSymbol) AK002931 ENSMUST00000224766.1 uc289okr.1 uc289okr.2 uc289okr.1 uc289okr.2 
ENSMUST00000224767.3 Gm31393 ENSMUST00000224767.3 Gm31393 (from geneSymbol) ENSMUST00000224767.1 ENSMUST00000224767.2 uc288slu.1 uc288slu.2 uc288slu.3 uc288slu.1 uc288slu.2 uc288slu.3 
ENSMUST00000224797.2 Actr8 ENSMUST00000224797.2 Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity). (from UniProt Q8R2S9) AK017815 ARP8_MOUSE Arp8 ENSMUST00000224797.1 Q8R2S9 Q9CYC4 uc288rvk.1 uc288rvk.2 Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity). Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core (By similarity). Nucleus Chromosome Note=Specifically localizes to mitotic chromosomes. Belongs to the actin family. ARP8 subfamily. nucleotide binding ATP binding nucleus chromosome centrosome DNA repair double-strand break repair DNA recombination chromatin remodeling regulation of transcription, DNA-templated cellular response to DNA damage stimulus cell cycle Ino80 complex ATP-dependent chromatin remodeling cell division uc288rvk.1 uc288rvk.2 
ENSMUST00000224800.2 B230220B15Rik ENSMUST00000224800.2 B230220B15Rik (from geneSymbol) BC061633 ENSMUST00000224800.1 uc288puw.1 uc288puw.2 uc288puw.1 uc288puw.2 
ENSMUST00000224802.2 4930579J19Rik ENSMUST00000224802.2 4930579J19Rik (from geneSymbol) AK016326 ENSMUST00000224802.1 uc288mef.1 uc288mef.2 uc288mef.1 uc288mef.2 
ENSMUST00000224808.2 4930469B13Rik ENSMUST00000224808.2 4930469B13Rik (from geneSymbol) AK019641 ENSMUST00000224808.1 uc288rdz.1 uc288rdz.2 uc288rdz.1 uc288rdz.2 
ENSMUST00000224822.2 Gm48775 ENSMUST00000224822.2 Gm48775 (from geneSymbol) ENSMUST00000224822.1 uc289rlz.1 uc289rlz.2 uc289rlz.1 uc289rlz.2 
ENSMUST00000224831.2 Gm47907 ENSMUST00000224831.2 Gm47907 (from geneSymbol) ENSMUST00000224831.1 uc288rov.1 uc288rov.2 uc288rov.1 uc288rov.2 
ENSMUST00000224844.2 F630042J09Rik ENSMUST00000224844.2 F630042J09Rik (from geneSymbol) AK154519 ENSMUST00000224844.1 uc288oea.1 uc288oea.2 uc288oea.1 uc288oea.2 
ENSMUST00000224849.3 Gm48107 ENSMUST00000224849.3 Gm48107 (from geneSymbol) ENSMUST00000224849.1 ENSMUST00000224849.2 uc288mgs.1 uc288mgs.2 uc288mgs.3 uc288mgs.1 uc288mgs.2 uc288mgs.3 
ENSMUST00000224850.2 Gm30363 ENSMUST00000224850.2 Gm30363 (from geneSymbol) AK041475 ENSMUST00000224850.1 uc288rjw.1 uc288rjw.2 uc288rjw.1 uc288rjw.2 
ENSMUST00000224851.2 Gm48357 ENSMUST00000224851.2 Gm48357 (from geneSymbol) ENSMUST00000224851.1 uc288nfi.1 uc288nfi.2 uc288nfi.1 uc288nfi.2 
ENSMUST00000224870.2 Gm47119 ENSMUST00000224870.2 Gm47119 (from geneSymbol) ENSMUST00000224870.1 uc289lmz.1 uc289lmz.2 uc289lmz.1 uc289lmz.2 
ENSMUST00000224879.2 Gm11342 ENSMUST00000224879.2 Gm11342 (from geneSymbol) AK172386 ENSMUST00000224879.1 uc007pvs.1 uc007pvs.2 uc007pvs.3 uc007pvs.1 uc007pvs.2 uc007pvs.3 
ENSMUST00000224895.3 Gm47351 ENSMUST00000224895.3 Gm47351 (from geneSymbol) ENSMUST00000224895.1 ENSMUST00000224895.2 uc288mfn.1 uc288mfn.2 uc288mfn.3 uc288mfn.1 uc288mfn.2 uc288mfn.3 
ENSMUST00000224897.2 Zdhhc6 ENSMUST00000224897.2 zinc finger, DHHC domain containing 6, transcript variant 2 (from RefSeq NM_025883.4) ENSMUST00000224897.1 NM_025883 Q3U3I8 Q3UT70 Q544H1 Q9CPV7 ZDHC6_MOUSE Zdhhc6 uc008hxt.1 uc008hxt.2 uc008hxt.3 uc008hxt.4 Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (PubMed:25368151). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (By similarity). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (By similarity). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation (By similarity). Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Reaction=L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S- octadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59740, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:15434, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:143200; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59741; Evidence=; Homooligomerizes (By similarity). Interacts with SELENOK (PubMed:25368151). Endoplasmic reticulum membrane ; Multi-pass membrane protein Note=When not palmitoylated, accumulates to dot-like structures in the endoplasmic reticulum. Event=Alternative splicing; Named isoforms=4; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9CPV7-1; Sequence=Displayed; Name=2; IsoId=Q9CPV7-2; Sequence=VSP_006939, VSP_006940; Name=3; IsoId=Q9CPV7-3; Sequence=VSP_006941; Name=4; IsoId=Q9CPV7-4; Sequence=VSP_016270; The DHHC domain is required for palmitoyltransferase activity. The C-terminal di-lysine motif confers endoplasmic reticulum localization. Palmitoylated at 3 different sites by ZDHHC16. The combination of the different palmitoylation events strongly affects the quaternary assembly of ZDHHC6, its localization, stability and function. Palmitoylation at Cys-328 accelerates the turnover of ZDHHC6. Depalmitoylated by LYPLA2. Belongs to the DHHC palmitoyltransferase family. protein binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity uc008hxt.1 uc008hxt.2 uc008hxt.3 uc008hxt.4 
ENSMUST00000224905.2 Slc35b2 ENSMUST00000224905.2 solute carrier family 35, member B2 (from RefSeq NM_001357105.1) ENSMUST00000224905.1 J207 NM_001357105 Q3U221 Q8BTH2 Q91ZN5 S35B2_MOUSE Slc35b2 uc008cqx.1 uc008cqx.2 uc008cqx.3 Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'- phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment. Reaction=3'-phosphoadenylyl sulfate(in) + adenosine 3',5'- bisphosphate(out) = 3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in); Xref=Rhea:RHEA:76063, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343; Evidence=; Golgi apparatus membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91ZN5-1; Sequence=Displayed; Name=2; IsoId=Q91ZN5-2; Sequence=VSP_014085; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. Sequence=BAC41173.1; Type=Frameshift; Evidence=; Golgi membrane Golgi apparatus membrane integral component of membrane transmembrane transporter activity integral component of Golgi membrane integral component of endoplasmic reticulum membrane 3'-phosphoadenosine 5'-phosphosulfate transport 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity transmembrane transport 3'-phospho-5'-adenylyl sulfate transmembrane transport uc008cqx.1 uc008cqx.2 uc008cqx.3 
ENSMUST00000224910.3 Gm34585 ENSMUST00000224910.3 predicted gene, 34585 (from RefSeq NR_166903.1) ENSMUST00000224910.1 ENSMUST00000224910.2 NR_166903 uc288ozw.1 uc288ozw.2 uc288ozw.3 uc288ozw.1 uc288ozw.2 uc288ozw.3 
ENSMUST00000224911.2 Gm41192 ENSMUST00000224911.2 Gm41192 (from geneSymbol) ENSMUST00000224911.1 uc288vja.1 uc288vja.2 uc288vja.1 uc288vja.2 
ENSMUST00000224917.3 ENSMUSG00000121625 ENSMUST00000224917.3 ENSMUSG00000121625 (from geneSymbol) BC049692 ENSMUST00000224917.1 ENSMUST00000224917.2 uc288occ.1 uc288occ.2 uc288occ.3 uc288occ.1 uc288occ.2 uc288occ.3 
ENSMUST00000224920.2 Gm49098 ENSMUST00000224920.2 Gm49098 (from geneSymbol) BC115731 ENSMUST00000224920.1 uc288rnt.1 uc288rnt.2 uc288rnt.1 uc288rnt.2 
ENSMUST00000224935.2 Gm31683 ENSMUST00000224935.2 Gm31683 (from geneSymbol) ENSMUST00000224935.1 uc288mgx.1 uc288mgx.2 uc288mgx.1 uc288mgx.2 
ENSMUST00000224937.2 Gm47316 ENSMUST00000224937.2 Gm47316 (from geneSymbol) ENSMUST00000224937.1 uc288mgc.1 uc288mgc.2 uc288mgc.1 uc288mgc.2 
ENSMUST00000224942.2 Gm48441 ENSMUST00000224942.2 Gm48441 (from geneSymbol) ENSMUST00000224942.1 uc288nfk.1 uc288nfk.2 uc288nfk.1 uc288nfk.2 
ENSMUST00000224947.2 Trip10 ENSMUST00000224947.2 thyroid hormone receptor interactor 10, transcript variant 3 (from RefSeq NM_134125.5) CIP4_MOUSE Cip4 ENSMUST00000224947.1 NM_134125 Q8BTR8 Q8CJ53 Q8R433 Q99LI0 uc008dej.1 uc008dej.2 uc008dej.3 uc008dej.4 Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL (By similarity). Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures (By similarity). Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, PDE6G, SRC and WAS/WASP. Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. May interact with CTNNB1 and HD/HTT (By similarity). Interacts specifically with GTP-bound CDC42 and RHOQ. Interacts with DNM2 and WASL. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus Cell membrane. Cell projection, phagocytic cup Note=Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9 (By similarity). Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Cip4/2; IsoId=Q8CJ53-1; Sequence=Displayed; Name=2; Synonyms=H; IsoId=Q8CJ53-2; Sequence=VSP_021723; Name=3; IsoId=Q8CJ53-3; Sequence=VSP_021722; Name=4; IsoId=Q8CJ53-4; Sequence=VSP_021722, VSP_021723; The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity). Tyrosine phosphorylated. Also phosphorylated by PKA (By similarity). Belongs to the FNBP1 family. epithelial to mesenchymal transition phagocytic cup protein binding nucleoplasm cytoplasm lysosome Golgi apparatus cytoskeleton microtubule plasma membrane cell cortex endocytosis lipid binding negative regulation of cardiac muscle cell apoptotic process membrane actin cytoskeleton organization hyperosmotic salinity response identical protein binding cell projection intracellular membrane-bounded organelle positive regulation of cell growth involved in cardiac muscle cell development uc008dej.1 uc008dej.2 uc008dej.3 uc008dej.4 
ENSMUST00000224981.2 Arhgef3 ENSMUST00000224981.2 Rho guanine nucleotide exchange factor 3, transcript variant 4 (from RefSeq NM_001289688.1) ARHG3_MOUSE ENSMUST00000224981.1 NM_001289688 Q8CDM0 Q91VY4 Q91X46 Q99K14 Q9DC31 uc007str.1 uc007str.2 uc007str.3 uc007str.4 Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. Interacts with RHOA and RHOB. Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q91X46-1; Sequence=Displayed; Name=2; IsoId=Q91X46-2; Sequence=VSP_011613; Name=3; IsoId=Q91X46-3; Sequence=VSP_011614; Sequence=AAH07153.1; Type=Erroneous initiation; Evidence=; guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity cytoplasm regulation of Rho protein signal transduction intracellular signal transduction uc007str.1 uc007str.2 uc007str.3 uc007str.4 
ENSMUST00000224982.2 Spata31d1a ENSMUST00000224982.2 Membrane ; Single- pass membrane protein (from UniProt E9QA35) AK029673 E9QA35 E9QA35_MOUSE ENSMUST00000224982.1 Fam75d1a Spata31d1a uc007quz.1 uc007quz.2 uc007quz.3 Membrane ; Single- pass membrane protein Belongs to the SPATA31 family. molecular_function cellular_component biological_process membrane integral component of membrane uc007quz.1 uc007quz.2 uc007quz.3 
ENSMUST00000224986.2 Cts7 ENSMUST00000224986.2 cathepsin 7, transcript variant 2 (from RefSeq NM_001359387.1) CAT7_MOUSE Cts1 Cts7 ENSMUST00000224986.1 Epcs24 NM_001359387 Q91ZF2 Q9JI84 uc288nnk.1 uc288nnk.2 Involved in trophoblast cell proliferation and differentiation probably by affecting mitotic cell cycle progression. Proteolytic activity and nuclear localization are essential for its role in cell cycle progression. Endosome sosome Cytoplasm, perinuclear region Golgi apparatus Nucleus Secreted, extracellular space Expressed in placenta. Expressed in parietal and spiral artery-associated trophoblast giant cells, most abundantly during the phase of trophoblast invasion. From 14.5 dpc onwards, expressed at lower levels in labyrinth trophoblast cells. Expressed in trophoblast stem cells. Expressed in heart, liver and testis. Expressed in adult but not in embryo. Expressed in the placenta from early post-implantation (5.5 dpc) onwards. After 9.5 dpc expression declines. Belongs to the peptidase C1 family. cysteine-type endopeptidase activity extracellular region extracellular space nucleus cytoplasm lysosome endosome Golgi apparatus proteolysis cell cycle peptidase activity cysteine-type peptidase activity hydrolase activity negative regulation of mitotic cell cycle perinuclear region of cytoplasm cell division proteolysis involved in cellular protein catabolic process trophoblast giant cell differentiation uc288nnk.1 uc288nnk.2 
ENSMUST00000224988.2 Gm48706 ENSMUST00000224988.2 Gm48706 (from geneSymbol) ENSMUST00000224988.1 uc288lzs.1 uc288lzs.2 uc288lzs.1 uc288lzs.2 
ENSMUST00000224991.2 Gm48860 ENSMUST00000224991.2 Gm48860 (from geneSymbol) ENSMUST00000224991.1 uc288qxc.1 uc288qxc.2 uc288qxc.1 uc288qxc.2 
ENSMUST00000224997.2 Gm49395 ENSMUST00000224997.2 Gm49395 (from geneSymbol) A0A286YCN5 A0A286YCN5_MOUSE AK077286 ENSMUST00000224997.1 Gm49395 uc288qco.1 uc288qco.2 uc288qco.1 uc288qco.2 
ENSMUST00000225017.2 Gm48250 ENSMUST00000225017.2 Gm48250 (from geneSymbol) ENSMUST00000225017.1 uc288mox.1 uc288mox.2 uc288mox.1 uc288mox.2 
ENSMUST00000225020.2 Gm46392 ENSMUST00000225020.2 Gm46392 (from geneSymbol) AK133313 ENSMUST00000225020.1 uc288mex.1 uc288mex.2 uc288mex.1 uc288mex.2 
ENSMUST00000225023.2 Rps24 ENSMUST00000225023.2 ribosomal protein S24, transcript variant 2 (from RefSeq NM_207634.3) ENSMUST00000225023.1 NM_207634 Q5M9M7 Q5M9M7_MOUSE Rps24 uc007sre.1 uc007sre.2 uc007sre.3 Belongs to the eukaryotic ribosomal protein eS24 family. structural constituent of ribosome ribosome translation small ribosomal subunit uc007sre.1 uc007sre.2 uc007sre.3 
ENSMUST00000225029.2 Tcstv4 ENSMUST00000225029.2 Tcstv family member 4, transcript variant 4 (from RefSeq NM_001424722.1) BC147527 ENSMUST00000225029.1 Gm8953 LOC625360 NM_001424722 Q3V185 Q3V185_MOUSE uc009shv.1 uc009shv.2 uc009shv.3 uc009shv.4 uc009shv.5 uc009shv.6 uc009shv.1 uc009shv.2 uc009shv.3 uc009shv.4 uc009shv.5 uc009shv.6 
ENSMUST00000225040.3 Gm47523 ENSMUST00000225040.3 Gm47523 (from geneSymbol) ENSMUST00000225040.1 ENSMUST00000225040.2 uc288mod.1 uc288mod.2 uc288mod.3 uc288mod.1 uc288mod.2 uc288mod.3 
ENSMUST00000225044.2 A430090L17Rik ENSMUST00000225044.2 RIKEN cDNA A430090L17 gene (from RefSeq NR_045836.1) ENSMUST00000225044.1 NR_045836 uc029sdh.1 uc029sdh.2 uc029sdh.1 uc029sdh.2 
ENSMUST00000225045.2 B020004C17Rik ENSMUST00000225045.2 B020004C17Rik (from geneSymbol) AK139551 ENSMUST00000225045.1 uc007ucu.1 uc007ucu.2 uc007ucu.3 uc007ucu.1 uc007ucu.2 uc007ucu.3 
ENSMUST00000225049.2 Gm47520 ENSMUST00000225049.2 Gm47520 (from geneSymbol) ENSMUST00000225049.1 uc288pau.1 uc288pau.2 uc288pau.1 uc288pau.2 
ENSMUST00000225058.2 Gm47920 ENSMUST00000225058.2 Gm47920 (from geneSymbol) ENSMUST00000225058.1 uc288rpe.1 uc288rpe.2 uc288rpe.1 uc288rpe.2 
ENSMUST00000225060.2 4631422I05Rik ENSMUST00000225060.2 4631422I05Rik (from geneSymbol) ENSMUST00000225060.1 uc288qbe.1 uc288qbe.2 uc288qbe.1 uc288qbe.2 
ENSMUST00000225083.3 Gm43305 ENSMUST00000225083.3 predicted gene 43305 (from RefSeq NR_169007.1) ENSMUST00000225083.1 ENSMUST00000225083.2 NR_169007 uc288uew.1 uc288uew.2 uc288uew.3 uc288uew.1 uc288uew.2 uc288uew.3 
ENSMUST00000225097.2 Gm48500 ENSMUST00000225097.2 Gm48500 (from geneSymbol) ENSMUST00000225097.1 uc288nls.1 uc288nls.2 uc288nls.1 uc288nls.2 
ENSMUST00000225099.2 Gm48265 ENSMUST00000225099.2 Gm48265 (from geneSymbol) ENSMUST00000225099.1 uc288qfh.1 uc288qfh.2 uc288qfh.1 uc288qfh.2 
ENSMUST00000225101.2 Gm47359 ENSMUST00000225101.2 Gm47359 (from geneSymbol) AK038606 ENSMUST00000225101.1 uc288nhz.1 uc288nhz.2 uc288nhz.1 uc288nhz.2 
ENSMUST00000225110.2 Dsc3 ENSMUST00000225110.2 desmocollin 3, transcript variant 1 (from RefSeq NM_007882.3) DSC3_MOUSE ENSMUST00000225110.1 G5E8S6 NM_007882 O55110 O55122 P55850 uc008eeb.1 uc008eeb.2 uc008eeb.3 This gene encodes a member of the cadherin family of proteins that mediates adhesion in desmosomes. Together with desmogleins, the encoded protein forms the transmembrane core of desmosomes, a multiprotein complex involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. Mice lacking the encoded protein exhibit a pre-implantation lethal phenotype. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2016]. Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Cell membrane ; Single-pass type I membrane protein Cell junction, desmosome Event=Alternative splicing; Named isoforms=2; Name=3A; IsoId=P55850-1; Sequence=Displayed; Name=3B; IsoId=P55850-2; Sequence=VSP_000665, VSP_000666; First expressed at 13.0 dpc in epithelium of whisker pads and external nares, and in most mature vibrissa follicles. 12 hours later, prominently expressed in whiskers and tactile follicles above the eye. At 14.5 dpc, also expressed in developing nails and teeth and, at low levels, in ventral and lateral skin. At 15.5 dpc, highly expressed in general body epidermis and at 16.5 dpc, detected over entire embryo. In the adult, highly expressed in basal layers of stratified cells. Calcium may be bound by the cadherin-like repeats. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Sequence=CAA72045.1; Type=Frameshift; Evidence=; in utero embryonic development calcium ion binding extracellular region cytoplasm plasma membrane cell-cell junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules membrane integral component of membrane cell junction desmosome gamma-catenin binding metal ion binding protein stabilization cell-cell adhesion uc008eeb.1 uc008eeb.2 uc008eeb.3 
ENSMUST00000225122.2 9630015K15Rik ENSMUST00000225122.2 RIKEN cDNA 9630015K15 gene (from RefSeq NR_167725.1) ENSMUST00000225122.1 NR_167725 uc007uif.1 uc007uif.2 uc007uif.3 uc007uif.1 uc007uif.2 uc007uif.3 
ENSMUST00000225123.2 Gm47349 ENSMUST00000225123.2 Gm47349 (from geneSymbol) ENSMUST00000225123.1 uc288mfm.1 uc288mfm.2 uc288mfm.1 uc288mfm.2 
ENSMUST00000225136.2 Gm48437 ENSMUST00000225136.2 Gm48437 (from geneSymbol) AK143242 ENSMUST00000225136.1 uc288qst.1 uc288qst.2 uc288qst.1 uc288qst.2 
ENSMUST00000225144.2 Tcstv1b ENSMUST00000225144.2 2 cell stage variable group member 1B (from RefSeq NM_001371093.1) ENSMUST00000225144.1 Gm21818 J3KMS6 J3KMS6_MOUSE NM_001371093 uc288qgj.1 uc288qgj.2 uc288qgj.1 uc288qgj.2 
ENSMUST00000225152.2 Gm48602 ENSMUST00000225152.2 Gm48602 (from geneSymbol) ENSMUST00000225152.1 uc288qtg.1 uc288qtg.2 uc288qtg.1 uc288qtg.2 
ENSMUST00000225154.2 Gm48704 ENSMUST00000225154.2 Gm48704 (from geneSymbol) AK132605 ENSMUST00000225154.1 uc007qcd.1 uc007qcd.2 uc007qcd.3 uc007qcd.1 uc007qcd.2 uc007qcd.3 
ENSMUST00000225158.2 Gm41118 ENSMUST00000225158.2 Gm41118 (from geneSymbol) ENSMUST00000225158.1 uc288ruz.1 uc288ruz.2 uc288ruz.1 uc288ruz.2 
ENSMUST00000225160.2 Gm48004 ENSMUST00000225160.2 Gm48004 (from geneSymbol) ENSMUST00000225160.1 uc288ruo.1 uc288ruo.2 uc288ruo.1 uc288ruo.2 
ENSMUST00000225162.2 C630044B11Rik ENSMUST00000225162.2 C630044B11Rik (from geneSymbol) AK047732 ENSMUST00000225162.1 uc288nho.1 uc288nho.2 uc288nho.1 uc288nho.2 
ENSMUST00000225163.2 Gm30806 ENSMUST00000225163.2 Gm30806 (from geneSymbol) ENSMUST00000225163.1 uc288vht.1 uc288vht.2 uc288vht.1 uc288vht.2 
ENSMUST00000225172.2 Gm48488 ENSMUST00000225172.2 Gm48488 (from geneSymbol) ENSMUST00000225172.1 uc288nlj.1 uc288nlj.2 uc288nlj.1 uc288nlj.2 
ENSMUST00000225197.3 Zswim6 ENSMUST00000225197.3 zinc finger SWIM-type containing 6 (from RefSeq NM_145456.3) A0A7N9VSH7 A0A7N9VSH7_MOUSE ENSMUST00000225197.1 ENSMUST00000225197.2 NM_145456 Zswim6 uc288pus.1 uc288pus.2 uc288pus.1 uc288pus.2 
ENSMUST00000225199.2 Gm10779 ENSMUST00000225199.2 Gm10779 (from geneSymbol) ENSMUST00000225199.1 uc288nlo.1 uc288nlo.2 uc288nlo.1 uc288nlo.2 
ENSMUST00000225200.2 Egr3 ENSMUST00000225200.2 early growth response 3, transcript variant 1 (from RefSeq NM_018781.4) EGR3_MOUSE ENSMUST00000225200.1 Egr-3 NM_018781 P43300 Q9R276 uc007unb.1 uc007unb.2 uc007unb.3 uc007unb.4 Probable transcription factor involved in muscle spindle development. Nucleus Belongs to the EGR C2H2-type zinc-finger protein family. RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding positive regulation of endothelial cell proliferation cell migration involved in sprouting angiogenesis nucleic acid binding DNA binding nucleus regulation of transcription from RNA polymerase II promoter neuromuscular synaptic transmission peripheral nervous system development positive regulation of T cell differentiation in thymus endothelial cell chemotaxis cellular response to vascular endothelial growth factor stimulus negative regulation of apoptotic process sequence-specific DNA binding cellular response to fibroblast growth factor stimulus regulation of gamma-delta T cell differentiation positive regulation of transcription from RNA polymerase II promoter metal ion binding uc007unb.1 uc007unb.2 uc007unb.3 uc007unb.4 
ENSMUST00000225201.2 Gm49064 ENSMUST00000225201.2 Gm49064 (from geneSymbol) ENSMUST00000225201.1 uc288odx.1 uc288odx.2 uc288odx.1 uc288odx.2 
ENSMUST00000225204.2 Gm48603 ENSMUST00000225204.2 Gm48603 (from geneSymbol) ENSMUST00000225204.1 uc288qtm.1 uc288qtm.2 uc288qtm.1 uc288qtm.2 
ENSMUST00000225219.2 Gm48581 ENSMUST00000225219.2 Gm48581 (from geneSymbol) ENSMUST00000225219.1 uc057bdg.1 uc057bdg.2 uc057bdg.1 uc057bdg.2 
ENSMUST00000225225.2 Gm47743 ENSMUST00000225225.2 Gm47743 (from geneSymbol) AK030544 ENSMUST00000225225.1 uc288qyx.1 uc288qyx.2 uc288qyx.1 uc288qyx.2 
ENSMUST00000225228.2 Gm47849 ENSMUST00000225228.2 Gm47849 (from geneSymbol) AK040443 ENSMUST00000225228.1 uc288prq.1 uc288prq.2 uc288prq.1 uc288prq.2 
ENSMUST00000225230.2 Gm47246 ENSMUST00000225230.2 Gm47246 (from geneSymbol) AK028487 ENSMUST00000225230.1 uc288njl.1 uc288njl.2 uc288njl.1 uc288njl.2 
ENSMUST00000225244.2 4930415C11Rik ENSMUST00000225244.2 4930415C11Rik (from geneSymbol) AK015143 ENSMUST00000225244.1 uc288nhs.1 uc288nhs.2 uc288nhs.1 uc288nhs.2 
ENSMUST00000225257.3 Gm47707 ENSMUST00000225257.3 Gm47707 (from geneSymbol) ENSMUST00000225257.1 ENSMUST00000225257.2 uc288mbj.1 uc288mbj.2 uc288mbj.3 uc288mbj.1 uc288mbj.2 uc288mbj.3 
ENSMUST00000225259.2 Slc34a1 ENSMUST00000225259.2 Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in); Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71256; Evidence=; (from UniProt Q9D2V6) AB163921 ENSMUST00000225259.1 Npt2a Q9D2V6 Q9D2V6_MOUSE Slc34a1 uc288nbp.1 uc288nbp.2 Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in); Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71256; Evidence=; Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the SLC34A transporter family. ossification kidney development endosome plasma membrane phosphate ion transport response to nutrient glycoprotein metabolic process cell surface response to lead ion sodium-dependent phosphate transmembrane transporter activity membrane integral component of membrane apical plasma membrane nuclear speck PDZ domain binding intrinsic component of plasma membrane brush border membrane response to magnesium ion response to estradiol response to vitamin A phosphate ion transmembrane transport response to potassium ion indole metabolic process response to drug protein homodimerization activity response to peptide hormone sodium-dependent phosphate transport macromolecular complex binding membrane raft positive regulation of membrane potential response to cadmium ion response to mercury ion perinuclear region of cytoplasm protein homooligomerization phosphate ion homeostasis response to growth hormone response to parathyroid hormone cellular response to metal ion cellular response to parathyroid hormone stimulus tricarboxylic acid metabolic process mitotic spindle cellular response to staurosporine response to thyroid hormone dentinogenesis sodium ion import across plasma membrane gentamycin metabolic process response to peptide arsenate ion transmembrane transport positive regulation of sodium-dependent phosphate transport positive regulation of phosphate transmembrane transport uc288nbp.1 uc288nbp.2 
ENSMUST00000225263.2 Gm47551 ENSMUST00000225263.2 Gm47551 (from geneSymbol) ENSMUST00000225263.1 uc288plh.1 uc288plh.2 uc288plh.1 uc288plh.2 
ENSMUST00000225265.2 Gm48056 ENSMUST00000225265.2 Gm48056 (from geneSymbol) ENSMUST00000225265.1 uc288mek.1 uc288mek.2 uc288mek.1 uc288mek.2 
ENSMUST00000225266.2 A530065N20Rik ENSMUST00000225266.2 RIKEN cDNA A530046M15 gene (from RefSeq NR_046142.1) ENSMUST00000225266.1 NR_046142 uc029sbo.1 uc029sbo.2 uc029sbo.1 uc029sbo.2 
ENSMUST00000225272.3 Gm35217 ENSMUST00000225272.3 Gm35217 (from geneSymbol) ENSMUST00000225272.1 ENSMUST00000225272.2 uc288rue.1 uc288rue.2 uc288rue.3 uc288rue.1 uc288rue.2 uc288rue.3 
ENSMUST00000225273.3 Gm47995 ENSMUST00000225273.3 Gm47995 (from geneSymbol) A0A286YDP4 A0A286YDP4_MOUSE ENSMUST00000225273.1 ENSMUST00000225273.2 Gm47995 uc287mms.1 uc287mms.2 uc287mms.3 uc287mms.1 uc287mms.2 uc287mms.3 
ENSMUST00000225276.2 A530001N23Rik ENSMUST00000225276.2 A530001N23Rik (from geneSymbol) AK040640 ENSMUST00000225276.1 uc288nlu.1 uc288nlu.2 uc288nlu.1 uc288nlu.2 
ENSMUST00000225277.2 Gm48746 ENSMUST00000225277.2 Gm48746 (from geneSymbol) ENSMUST00000225277.1 uc288lzw.1 uc288lzw.2 uc288lzw.1 uc288lzw.2 
ENSMUST00000225278.2 Gm47985 ENSMUST00000225278.2 Gm47985 (from geneSymbol) A0A286YCH8 A0A286YCH8_MOUSE ENSMUST00000225278.1 Gm47985 uc287mmq.1 uc287mmq.2 uc287mmq.1 uc287mmq.2 
ENSMUST00000225280.2 Gm48594 ENSMUST00000225280.2 Gm48594 (from geneSymbol) ENSMUST00000225280.1 uc288qtb.1 uc288qtb.2 uc288qtb.1 uc288qtb.2 
ENSMUST00000225283.3 Gm47936 ENSMUST00000225283.3 Gm47936 (from geneSymbol) ENSMUST00000225283.1 ENSMUST00000225283.2 uc289sbn.1 uc289sbn.2 uc289sbn.3 uc289sbn.1 uc289sbn.2 uc289sbn.3 
ENSMUST00000225304.2 Gm47509 ENSMUST00000225304.2 Gm47509 (from geneSymbol) ENSMUST00000225304.1 uc288mew.1 uc288mew.2 uc288mew.1 uc288mew.2 
ENSMUST00000225307.2 4930455M05Rik ENSMUST00000225307.2 4930455M05Rik (from geneSymbol) ENSMUST00000225307.1 uc288nik.1 uc288nik.2 uc288nik.1 uc288nik.2 
ENSMUST00000225327.2 4930405A10Rik ENSMUST00000225327.2 RIKEN cDNA 4930405A10 gene (from RefSeq NR_046307.1) ENSMUST00000225327.1 NR_046307 uc007slx.1 uc007slx.2 uc007slx.3 uc007slx.1 uc007slx.2 uc007slx.3 
ENSMUST00000225330.2 Prl3d1 ENSMUST00000225330.2 prolactin family 3, subfamily d, member 1, transcript variant 1 (from RefSeq NM_001205322.1) A0A286YC78 A0A286YC78_MOUSE ENSMUST00000225330.1 Ghd4 NM_001205322 Prl3d1 uc007pxe.1 uc007pxe.2 uc007pxe.3 uc007pxe.4 Secreted Belongs to the somatotropin/prolactin family. hormone activity extracellular region signal transduction uc007pxe.1 uc007pxe.2 uc007pxe.3 uc007pxe.4 
ENSMUST00000225337.3 Aldh1a1 ENSMUST00000225337.3 aldehyde dehydrogenase family 1, subfamily A1, transcript variant 4 (from RefSeq NM_001361506.1) AL1A1_MOUSE Ahd-2 Ahd2 Aldh1 Aldh1a1 ENSMUST00000225337.1 ENSMUST00000225337.2 NM_001361506 P24549 Q7TQJ0 Q811J0 uc289rju.1 uc289rju.2 uc289rju.3 Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12851412). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (PubMed:12851412). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (Probable). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4- hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:17567582). Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (PubMed:26430123). Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16186; Evidence=; Reaction=all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:42080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.36; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42081; Evidence=; Reaction=9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:42084, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78273, ChEBI:CHEBI:78630; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42085; Evidence=; Reaction=11-cis-retinal + H2O + NAD(+) = 11-cis-retinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:47132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16066, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:87435; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47133; Evidence=; Reaction=13-cis-retinal + H2O + NAD(+) = 13-cis-retinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:67332, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:45487, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:169952; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67333; Evidence=; Reaction=4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:19105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58264, ChEBI:CHEBI:59888; EC=1.2.1.19; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19106; Evidence=; Reaction=3-deoxyglucosone + H2O + NAD(+) = 2-dehydro-3-deoxy-D- gluconate + 2 H(+) + NADH; Xref=Rhea:RHEA:67244, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57990, ChEBI:CHEBI:60777; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67245; Evidence=; Reaction=(E)-4-hydroxynon-2-enal + H2O + NAD(+) = (E)-4-hydroxynon-2- enoate + 2 H(+) + NADH; Xref=Rhea:RHEA:67248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58968, ChEBI:CHEBI:142920; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67249; Evidence=; Reaction=H2O + malonaldehyde + NAD(+) = 3-oxopropanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:67252, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33190, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:566274; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67253; Evidence=; Reaction=H2O + hexanal + NAD(+) = 2 H(+) + hexanoate + NADH; Xref=Rhea:RHEA:67276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:88528; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67277; Evidence=; Reaction=H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate; Xref=Rhea:RHEA:67256, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17153, ChEBI:CHEBI:17272, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67257; Evidence=; Reaction=acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH; Xref=Rhea:RHEA:25294, ChEBI:CHEBI:15343, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25295; Evidence=; Reaction=benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH; Xref=Rhea:RHEA:11840, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16150, ChEBI:CHEBI:17169, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.28; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11841; Evidence=; The aminobutyraldehyde dehydrogenase activity is negatively regulated by ethanol in vivo. Cofactor metabolism; retinol metabolism. Homotetramer (By similarity). Interacts with PRMT3; the interaction is direct, inhibits ALDH1A1 aldehyde dehydrogenase activity and is independent of the methyltransferase activity of PRMT3 (By similarity). Cytoplasm, cytosol Cell projection, axon Expressed in retina (PubMed:1935685). Expressed in lens and cornea (at protein level) (PubMed:17567582). Expressed by midbrain dopamine neurons (PubMed:26430123). The N-terminus is blocked most probably by acetylation. Mice lacking Aldh1a1, obtained at the expected Mendelian ratio, are viable and fertile without obvious defects in growth or survival (PubMed:12851412). However, they are more sensitive to retinol toxicity and are less efficient at metabolizing excess retinol to retinoic acid/RA (PubMed:12851412). An excess of retinol leads to the accumulation of retinaldehyde in these mice (PubMed:12851412). Enhanced alcohol consumption and preference is also observed in knockout mice (PubMed:26430123). A consistent lenticular opacification is also detected in old mice (PubMed:17567582). Belongs to the aldehyde dehydrogenase family. Sequence=AAH44729.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; retinoid metabolic process retinal dehydrogenase activity optic cup morphogenesis involved in camera-type eye development retinoic acid biosynthetic process 3-chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity nucleus cytoplasm cytosol response to oxidative stress oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor benzaldehyde dehydrogenase (NAD+) activity response to drug retinol metabolic process retinoic acid metabolic process identical protein binding 9-cis-retinoic acid biosynthetic process 9-cis-retinoic acid metabolic process positive regulation of apoptotic process response to ethanol embryonic eye morphogenesis NAD binding protein homotetramerization oxidation-reduction process uc289rju.1 uc289rju.2 uc289rju.3 
ENSMUST00000225343.2 Gm10734 ENSMUST00000225343.2 predicted gene 10734, transcript variant 2 (from RefSeq NR_188849.1) ENSMUST00000225343.1 NR_188849 uc288qcq.1 uc288qcq.2 uc288qcq.1 uc288qcq.2 
ENSMUST00000225346.2 Gm47041 ENSMUST00000225346.2 Gm47041 (from geneSymbol) ENSMUST00000225346.1 uc288mgh.1 uc288mgh.2 uc288mgh.1 uc288mgh.2 
ENSMUST00000225355.2 Elp3 ENSMUST00000225355.2 elongator acetyltransferase complex subunit 3, transcript variant 2 (from RefSeq NM_028811.3) ELP3_MOUSE ENSMUST00000225355.1 Elp3 NM_028811 Q8C2K2 Q8R369 Q9CZX0 uc007ujk.1 uc007ujk.2 uc007ujk.3 uc007ujk.4 Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5- methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (By similarity). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha- tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (PubMed:28507509). Reaction=acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine; Xref=Rhea:RHEA:61020, Rhea:RHEA-COMP:10407, Rhea:RHEA-COMP:11727, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:65315, ChEBI:CHEBI:74882; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61021; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. ; tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Component of the elongator complex which consists of ELP1, ELP2, ELP3, ELP4, ELP5 and ELP6. ELP1, ELP2 and ELP3 form the elongator core complex. Interacts with alpha-tubulin. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CZX0-1; Sequence=Displayed; Name=2; IsoId=Q9CZX0-2; Sequence=VSP_024408; Ubiquitously expressed in blastocysts and 10.5 dpc embryos (PubMed:27476491). Expression increases during embryonic stem cell maintenance differentiation (PubMed:27476491). Tyrosine-phosphorylated. Also serine/threonine-phosphorylated. Embryonic lethality by 12.5 dpc caused by severe growth retardation (PubMed:27476491, PubMed:29415125). Conditional deletion in adults is also lethal (PubMed:29415125). Belongs to the ELP3 family. The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification. The relevance of the protein lysine acetyltransferase activity is unclear (By similarity). The publication reporting acetylation of GJA1 does not provide direct evidence of lysine acetyltransferase activity of ELP3 (PubMed:28507509). neuron migration tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis. catalytic activity nucleus nucleolus cytoplasm regulation of transcription from RNA polymerase II promoter nervous system development central nervous system development transcription elongation factor complex N-acetyltransferase activity phosphorylase kinase regulator activity acetyltransferase activity transferase activity transferase activity, transferring acyl groups positive regulation of cell migration Elongator holoenzyme complex regulation of protein kinase activity metal ion binding iron-sulfur cluster binding RNA polymerase II core binding uc007ujk.1 uc007ujk.2 uc007ujk.3 uc007ujk.4 
ENSMUST00000225358.3 A930028N01Rik ENSMUST00000225358.3 A930028N01Rik (from geneSymbol) AK020900 ENSMUST00000225358.1 ENSMUST00000225358.2 uc289rxl.1 uc289rxl.2 uc289rxl.3 uc289rxl.1 uc289rxl.2 uc289rxl.3 
ENSMUST00000225363.2 Gm30054 ENSMUST00000225363.2 Gm30054 (from geneSymbol) AK041570 ENSMUST00000225363.1 uc007sjm.1 uc007sjm.2 uc007sjm.1 uc007sjm.2 
ENSMUST00000225364.2 Gm48639 ENSMUST00000225364.2 Gm48639 (from geneSymbol) ENSMUST00000225364.1 uc288oru.1 uc288oru.2 uc288oru.1 uc288oru.2 
ENSMUST00000225371.2 Gm47360 ENSMUST00000225371.2 Gm47360 (from geneSymbol) ENSMUST00000225371.1 uc288nie.1 uc288nie.2 uc288nie.1 uc288nie.2 
ENSMUST00000225372.4 Gm21388 ENSMUST00000225372.4 Gm21388 (from geneSymbol) ENSMUST00000225372.1 ENSMUST00000225372.2 ENSMUST00000225372.3 uc008oyb.1 uc008oyb.2 uc008oyb.3 uc008oyb.4 uc008oyb.5 uc008oyb.6 uc008oyb.1 uc008oyb.2 uc008oyb.3 uc008oyb.4 uc008oyb.5 uc008oyb.6 
ENSMUST00000225374.2 Gm48356 ENSMUST00000225374.2 Gm48356 (from geneSymbol) ENSMUST00000225374.1 uc288lgu.1 uc288lgu.2 uc288lgu.1 uc288lgu.2 
ENSMUST00000225376.2 Gm48582 ENSMUST00000225376.2 Gm48582 (from geneSymbol) AK139717 ENSMUST00000225376.1 uc288nma.1 uc288nma.2 uc288nma.1 uc288nma.2 
ENSMUST00000225382.2 Gm49393 ENSMUST00000225382.2 Gm49393 (from geneSymbol) A0A286YD66 A0A286YD66_MOUSE AK015635 ENSMUST00000225382.1 Gm49393 uc288nmh.1 uc288nmh.2 uc288nmh.1 uc288nmh.2 
ENSMUST00000225387.3 Gm40922 ENSMUST00000225387.3 Gm40922 (from geneSymbol) ENSMUST00000225387.1 ENSMUST00000225387.2 uc288mel.1 uc288mel.2 uc288mel.3 uc288mel.1 uc288mel.2 uc288mel.3 
ENSMUST00000225388.2 Kif27 ENSMUST00000225388.2 Plays an essential role in motile ciliogenesis. (from UniProt Q7M6Z4) BC116646 ENSMUST00000225388.1 KIF27_MOUSE Q14AX5 Q7M6Z4 Q8BMB9 uc288nfs.1 uc288nfs.2 Plays an essential role in motile ciliogenesis. Interacts with STK36. Q7M6Z4; Q69ZM6: Stk36; NbExp=2; IntAct=EBI-15765182, EBI-15765145; Cytoplasm, cytoskeleton Cell projection, cilium Note=Localizes to centrioles and basal bodies. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=KIF27A; IsoId=Q7M6Z4-1; Sequence=Displayed; Name=2; IsoId=Q7M6Z4-2; Sequence=VSP_028607, VSP_028608; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily. nucleotide binding epithelial cilium movement microtubule motor activity protein binding ATP binding extracellular region cytoplasm cytoskeleton kinesin complex microtubule cilium microtubule-based movement microtubule binding ATPase activity ventricular system development cell projection organization cell projection cilium assembly uc288nfs.1 uc288nfs.2 
ENSMUST00000225395.2 Gm34471 ENSMUST00000225395.2 Gm34471 (from geneSymbol) AK041352 ENSMUST00000225395.1 uc288qas.1 uc288qas.2 uc288qas.1 uc288qas.2 
ENSMUST00000225398.2 Gm48824 ENSMUST00000225398.2 Gm48824 (from geneSymbol) ENSMUST00000225398.1 uc288oef.1 uc288oef.2 uc288oef.1 uc288oef.2 
ENSMUST00000225399.2 ENSMUSG00000121814 ENSMUST00000225399.2 ENSMUSG00000121814 (from geneSymbol) ENSMUST00000225399.1 uc288ods.1 uc288ods.2 uc288ods.1 uc288ods.2 
ENSMUST00000225413.2 Tjap1 ENSMUST00000225413.2 Plays a role in regulating the structure of the Golgi apparatus. (from UniProt Q9DCD5) AB712252 ENSMUST00000225413.1 I7H459 Pilt Q8CFL7 Q8R5I2 Q9DCD5 TJAP1_MOUSE Tjap1 Tjp4 uc033hee.1 uc033hee.2 uc033hee.3 Plays a role in regulating the structure of the Golgi apparatus. Interacts with DLG1 (By similarity). Interacts with ARF6 (GTP- bound form) (PubMed:22841714). Q9DCD5; P62331: Arf6; NbExp=2; IntAct=EBI-775733, EBI-988682; Golgi apparatus, trans-Golgi network Cell junction, tight junction Cell membrane ; Peripheral membrane protein Note=Recruited to tight junctions (TJ) during late stages of maturation of the TJ complexes. Excluded from adherens junctions and desmosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DCD5-1; Sequence=Displayed; Name=2; IsoId=Q9DCD5-2; Sequence=VSP_060915; Widely expressed including in adult thymus, heart, lung, liver, small intestine, kidney, spleen, testis and skeletal muscle and in embryonic brain but not detected in adult brain (at protein level). protein binding cytoplasm endosome Golgi apparatus trans-Golgi network plasma membrane bicellular tight junction Golgi organization cell junction uc033hee.1 uc033hee.2 uc033hee.3 
ENSMUST00000225416.3 Gm41030 ENSMUST00000225416.3 Gm41030 (from geneSymbol) ENSMUST00000225416.1 ENSMUST00000225416.2 uc288pjg.1 uc288pjg.2 uc288pjg.3 uc288pjg.1 uc288pjg.2 uc288pjg.3 
ENSMUST00000225432.2 Slc35b3 ENSMUST00000225432.2 solute carrier family 35, member B3, transcript variant 4 (from RefSeq NM_001403012.1) ENSMUST00000225432.1 NM_001403012 Q922Q5 S35B3_MOUSE Slc35b3 uc007qdz.1 uc007qdz.2 uc007qdz.3 uc007qdz.4 Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'- phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment. Reaction=3'-phosphoadenylyl sulfate(in) + adenosine 3',5'- bisphosphate(out) = 3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in); Xref=Rhea:RHEA:76063, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343; Evidence=; Golgi apparatus membrane ; Multi-pass membrane protein Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. Golgi membrane mitochondrion Golgi apparatus membrane integral component of membrane transmembrane transporter activity integral component of Golgi membrane integral component of endoplasmic reticulum membrane 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity transmembrane transport 3'-phospho-5'-adenylyl sulfate transmembrane transport uc007qdz.1 uc007qdz.2 uc007qdz.3 uc007qdz.4 
ENSMUST00000225434.2 Gm33321 ENSMUST00000225434.2 Gm33321 (from geneSymbol) ENSMUST00000225434.1 uc288uws.1 uc288uws.2 uc288uws.1 uc288uws.2 
ENSMUST00000225436.2 Gm47601 ENSMUST00000225436.2 Gm47601 (from geneSymbol) AK042465 ENSMUST00000225436.1 uc288rma.1 uc288rma.2 uc288rma.1 uc288rma.2 
ENSMUST00000225441.2 Gm47780 ENSMUST00000225441.2 Gm47780 (from geneSymbol) ENSMUST00000225441.1 uc288qzr.1 uc288qzr.2 uc288qzr.1 uc288qzr.2 
ENSMUST00000225453.2 Gm20242 ENSMUST00000225453.2 Gm20242 (from geneSymbol) AK157069 ENSMUST00000225453.1 uc288rtt.1 uc288rtt.2 uc288rtt.1 uc288rtt.2 
ENSMUST00000225455.2 Gm48510 ENSMUST00000225455.2 Gm48510 (from geneSymbol) ENSMUST00000225455.1 uc288mhp.1 uc288mhp.2 uc288mhp.1 uc288mhp.2 
ENSMUST00000225480.2 Gm48266 ENSMUST00000225480.2 Gm48266 (from geneSymbol) AK038485 ENSMUST00000225480.1 uc288quw.1 uc288quw.2 uc288quw.1 uc288quw.2 
ENSMUST00000225485.2 Gm34788 ENSMUST00000225485.2 Gm34788 (from geneSymbol) ENSMUST00000225485.1 uc288nii.1 uc288nii.2 uc288nii.1 uc288nii.2 
ENSMUST00000225499.3 Gm47510 ENSMUST00000225499.3 Gm47510 (from geneSymbol) ENSMUST00000225499.1 ENSMUST00000225499.2 uc288mes.1 uc288mes.2 uc288mes.3 uc288mes.1 uc288mes.2 uc288mes.3 
ENSMUST00000225500.2 Gm31517 ENSMUST00000225500.2 Gm31517 (from geneSymbol) AK147724 ENSMUST00000225500.1 uc288qyt.1 uc288qyt.2 uc288qyt.1 uc288qyt.2 
ENSMUST00000225507.2 Gm48095 ENSMUST00000225507.2 Gm48095 (from geneSymbol) ENSMUST00000225507.1 uc288ogc.1 uc288ogc.2 uc288ogc.1 uc288ogc.2 
ENSMUST00000225533.3 Gm47709 ENSMUST00000225533.3 Gm47709 (from geneSymbol) ENSMUST00000225533.1 ENSMUST00000225533.2 uc288mbl.1 uc288mbl.2 uc288mbl.3 uc288mbl.1 uc288mbl.2 uc288mbl.3 
ENSMUST00000225537.2 Ppp1r3g ENSMUST00000225537.2 Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits. (from UniProt Q9CW07) AK079637 ENSMUST00000225537.1 PP13G_MOUSE Q9CW07 uc033glg.1 uc033glg.2 uc033glg.3 Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits. Up-regulated during fasting and down-regulated after feeding. Sequence=BAB24130.1; Type=Frameshift; Evidence=; cytoplasm protein phosphatase binding glucose homeostasis positive regulation of glycogen biosynthetic process positive regulation of glycogen (starch) synthase activity glycogen binding uc033glg.1 uc033glg.2 uc033glg.3 
ENSMUST00000225545.2 Zscan12 ENSMUST00000225545.2 zinc finger and SCAN domain containing 12 (from RefSeq NM_016684.2) ENSMUST00000225545.1 NM_016684 Q8R0D8 Q9Z1D7 ZSC12_MOUSE Zfp96 Znf96 uc007pqd.1 uc007pqd.2 uc007pqd.3 May be involved in transcriptional regulation. Nucleus Testis specific. Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc007pqd.1 uc007pqd.2 uc007pqd.3 
ENSMUST00000225563.2 Gm48766 ENSMUST00000225563.2 Gm48766 (from geneSymbol) AB352048 ENSMUST00000225563.1 uc288mam.1 uc288mam.2 uc288mam.1 uc288mam.2 
ENSMUST00000225565.2 Gm31804 ENSMUST00000225565.2 Gm31804 (from geneSymbol) ENSMUST00000225565.1 uc288qzp.1 uc288qzp.2 uc288qzp.1 uc288qzp.2 
ENSMUST00000225567.2 Gm10873 ENSMUST00000225567.2 Gm10873 (from geneSymbol) AK133326 ENSMUST00000225567.1 uc288utd.1 uc288utd.2 uc288utd.1 uc288utd.2 
ENSMUST00000225569.2 Gm48648 ENSMUST00000225569.2 Gm48648 (from geneSymbol) ENSMUST00000225569.1 uc288mqe.1 uc288mqe.2 uc288mqe.1 uc288mqe.2 
ENSMUST00000225570.2 Gm8104 ENSMUST00000225570.2 Gm8104 (from geneSymbol) AK138450 ENSMUST00000225570.1 uc288sqx.1 uc288sqx.2 uc288sqx.1 uc288sqx.2 
ENSMUST00000225571.2 Gm34354 ENSMUST00000225571.2 Gm34354 (from geneSymbol) ENSMUST00000225571.1 uc288nhy.1 uc288nhy.2 uc288nhy.1 uc288nhy.2 
ENSMUST00000225573.2 Gm7480 ENSMUST00000225573.2 Gm7480 (from geneSymbol) AK086481 ENSMUST00000225573.1 uc288rlu.1 uc288rlu.2 uc288rlu.1 uc288rlu.2 
ENSMUST00000225575.2 Gm34388 ENSMUST00000225575.2 Gm34388 (from geneSymbol) AK054506 ENSMUST00000225575.1 uc288pjq.1 uc288pjq.2 uc288pjq.1 uc288pjq.2 
ENSMUST00000225579.2 Gm35110 ENSMUST00000225579.2 Gm35110 (from geneSymbol) ENSMUST00000225579.1 uc288mnz.1 uc288mnz.2 uc288mnz.1 uc288mnz.2 
ENSMUST00000225581.2 Gm49354 ENSMUST00000225581.2 Gm49354 (from geneSymbol) BC038047 ENSMUST00000225581.1 uc288nkm.1 uc288nkm.2 uc288nkm.1 uc288nkm.2 
ENSMUST00000225585.2 Pphln1-ps1 ENSMUST00000225585.2 periphilin 1, pseudogene 1 (from RefSeq NR_175936.1) ENSMUST00000225585.1 NR_175936 uc033gxt.1 uc033gxt.2 uc033gxt.3 uc033gxt.1 uc033gxt.2 uc033gxt.3 
ENSMUST00000225610.2 Gm29680 ENSMUST00000225610.2 predicted gene, 29680 (from RefSeq NR_188857.1) ENSMUST00000225610.1 NR_188857 uc007rjp.1 uc007rjp.2 uc007rjp.1 uc007rjp.2 
ENSMUST00000225653.2 Pxk ENSMUST00000225653.2 PX domain containing serine/threonine kinase, transcript variant L (from RefSeq NM_145458.4) ENSMUST00000225653.1 NM_145458 PXK_MOUSE Pxk Q3TD60 Q3TEL7 Q3TZZ1 Q3U197 Q3U773 Q3UCS5 Q4FBH7 Q8BX57 Q91WB6 uc007set.1 uc007set.2 uc007set.3 uc007set.4 Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. Cytoplasm Cell membrane ; Peripheral membrane protein Note=Also associates with the plasma membrane. Event=Alternative splicing; Named isoforms=3; Name=1 ; Synonyms=Long ; IsoId=Q8BX57-1; Sequence=Displayed; Name=2 ; Synonyms=Short ; IsoId=Q8BX57-2; Sequence=VSP_051916, VSP_051917; Name=3 ; IsoId=Q8BX57-3; Sequence=VSP_051914, VSP_051915; Isoform 1 is present in all tissues examined. Isoform 2 is found in all tissues except skeletal muscle and very low levels in spleen. Both isoforms are widely expressed throughout the nervous system however levels of isoform 2 are higher in purified hippocampal and cortical neurons whereas glial cells express more isoform 1 than isoform 2. The protein kinase domain is predicted to be catalytically inactive. Belongs to the protein kinase superfamily. Sequence=BAE33603.1; Type=Frameshift; Evidence=; Sequence=BAE33603.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; Sequence=BAE34065.1; Type=Frameshift; Evidence=; actin binding protein kinase activity ATP binding nucleus cytoplasm microtubule organizing center cytosol plasma membrane protein phosphorylation inflammatory response protein C-terminus binding membrane negative regulation of ATPase activity macromolecular complex phosphatidylinositol binding regulation of membrane potential negative regulation of ion transport modulation of synaptic transmission uc007set.1 uc007set.2 uc007set.3 uc007set.4 
ENSMUST00000225654.3 4930428N03Rik ENSMUST00000225654.3 4930428N03Rik (from geneSymbol) AK016429 ENSMUST00000225654.1 ENSMUST00000225654.2 uc288roq.1 uc288roq.2 uc288roq.3 uc288roq.1 uc288roq.2 uc288roq.3 
ENSMUST00000225657.2 Gm48566 ENSMUST00000225657.2 Gm48566 (from geneSymbol) ENSMUST00000225657.1 uc288ovh.1 uc288ovh.2 uc288ovh.1 uc288ovh.2 
ENSMUST00000225661.3 Trappc8 ENSMUST00000225661.3 trafficking protein particle complex 8, transcript variant 1 (from RefSeq NM_177038.3) A0A286YCX6 A0A286YCX6_MOUSE ENSMUST00000225661.1 ENSMUST00000225661.2 NM_177038 Trappc8 uc012bad.1 uc012bad.2 uc012bad.3 autophagosome assembly pre-autophagosomal structure molecular_function ER to Golgi vesicle-mediated transport Golgi organization TRAPP complex pexophagy cytoplasmic vesicle CVT pathway protein localization to pre-autophagosomal structure TRAPPIII protein complex uc012bad.1 uc012bad.2 uc012bad.3 
ENSMUST00000225666.2 Klhdc7b ENSMUST00000225666.2 kelch domain containing 7B (from RefSeq NM_001160178.2) A0A286YD60 A0A286YD60_MOUSE ENSMUST00000225666.1 Klhdc7b NM_001160178 uc289aqs.1 uc289aqs.2 uc289aqs.1 uc289aqs.2 
ENSMUST00000225669.2 Gm33172 ENSMUST00000225669.2 Gm33172 (from geneSymbol) AK142521 ENSMUST00000225669.1 uc288pww.1 uc288pww.2 uc288pww.1 uc288pww.2 
ENSMUST00000225671.3 Spin2-ps10 ENSMUST00000225671.3 Spin2-ps10 (from geneSymbol) ENSMUST00000225671.1 ENSMUST00000225671.2 uc292nqg.1 uc292nqg.2 uc292nqg.3 uc292nqg.1 uc292nqg.2 uc292nqg.3 
ENSMUST00000225672.2 8030423J24Rik ENSMUST00000225672.2 RIKEN cDNA 8030423J24 gene (from RefSeq NR_157373.1) ENSMUST00000225672.1 NR_157373 uc029scc.1 uc029scc.2 uc029scc.3 uc029scc.1 uc029scc.2 uc029scc.3 
ENSMUST00000225679.2 Gm47735 ENSMUST00000225679.2 Gm47735 (from geneSymbol) ENSMUST00000225679.1 uc289rtg.1 uc289rtg.2 uc289rtg.1 uc289rtg.2 
ENSMUST00000225683.2 Tcstv2c ENSMUST00000225683.2 two cell stage variable group member 2C (from RefSeq NM_001039648.3) ENSMUST00000225683.1 Gm20767 NM_001039648 O70517 O70517_MOUSE uc029sdt.1 uc029sdt.2 uc029sdt.3 uc029sdt.1 uc029sdt.2 uc029sdt.3 
ENSMUST00000225686.2 Gm47550 ENSMUST00000225686.2 Gm47550 (from geneSymbol) ENSMUST00000225686.1 LF199692 uc288pky.1 uc288pky.2 uc288pky.1 uc288pky.2 
ENSMUST00000225690.2 Gm49392 ENSMUST00000225690.2 Gm49392 (from geneSymbol) A0A286YDU1 A0A286YDU1_MOUSE BC061218 ENSMUST00000225690.1 Gm49392 uc288nmg.1 uc288nmg.2 uc288nmg.1 uc288nmg.2 
ENSMUST00000225691.3 Gm48449 ENSMUST00000225691.3 Gm48449 (from geneSymbol) ENSMUST00000225691.1 ENSMUST00000225691.2 uc288vfi.1 uc288vfi.2 uc288vfi.3 uc288vfi.1 uc288vfi.2 uc288vfi.3 
ENSMUST00000225696.2 Gm9984 ENSMUST00000225696.2 Gm9984 (from geneSymbol) AK043876 ENSMUST00000225696.1 uc289mme.1 uc289mme.2 uc289mme.1 uc289mme.2 
ENSMUST00000225706.2 Gm47040 ENSMUST00000225706.2 Gm47040 (from geneSymbol) ENSMUST00000225706.1 uc288qbq.1 uc288qbq.2 uc288qbq.1 uc288qbq.2 
ENSMUST00000225711.2 Gm48439 ENSMUST00000225711.2 Gm48439 (from geneSymbol) ENSMUST00000225711.1 uc288qsp.1 uc288qsp.2 uc288qsp.1 uc288qsp.2 
ENSMUST00000225718.2 Gm49616 ENSMUST00000225718.2 Gm49616 (from geneSymbol) ENSMUST00000225718.1 uc007stq.1 uc007stq.2 uc007stq.1 uc007stq.2 
ENSMUST00000225720.2 Mat1a ENSMUST00000225720.2 methionine adenosyltransferase 1A (from RefSeq NM_133653.3) ENSMUST00000225720.1 METK1_MOUSE NM_133653 Q91X83 uc007tcm.1 uc007tcm.2 uc007tcm.3 uc007tcm.4 This gene encodes a member of the AdoMet synthase family. Methionine adenosyltransferase is a product of this gene (the alpha form) and the beta form and catalyzes the formation of S-adenosylmethionine from methionine and ATP.[provided by RefSeq, Jan 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: L13622.1, BC011211.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. Reaction=ATP + H2O + L-methionine = diphosphate + phosphate + S- adenosyl-L-methionine; Xref=Rhea:RHEA:21080, ChEBI:CHEBI:15377, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789; EC=2.5.1.6; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate. ; Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence=; Note=Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate. ; Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. Homotetramer (MAT-I); dimer of dimers. Homodimer (MAT-III). S-nitrosylation of Cys-121 inactivates the enzyme. An intrachain disulfide bond can be formed. The protein structure shows that the relevant Cys residues are in a position that would permit formation of a disulfide bond. Belongs to the AdoMet synthase family. nucleotide binding magnesium ion binding methionine adenosyltransferase activity ATP binding cytosol S-adenosylmethionine biosynthetic process one-carbon metabolic process methionine catabolic process nuclear matrix amino acid binding transferase activity identical protein binding protein homodimerization activity ADP binding metal ion binding protein dimerization activity protein homooligomerization protein tetramerization protein homotetramerization uc007tcm.1 uc007tcm.2 uc007tcm.3 uc007tcm.4 
ENSMUST00000225729.3 ENSMUSG00000121807 ENSMUST00000225729.3 ENSMUSG00000121807 (from geneSymbol) AK007159 ENSMUST00000225729.1 ENSMUST00000225729.2 uc288rdr.1 uc288rdr.2 uc288rdr.3 uc288rdr.1 uc288rdr.2 uc288rdr.3 
ENSMUST00000225736.2 D14Ertd670e ENSMUST00000225736.2 DNA segment, Chr 14, ERATO Doi 670, expressed (from RefSeq NR_105025.1) ENSMUST00000225736.1 NR_105025 uc033goj.1 uc033goj.2 uc033goj.1 uc033goj.2 
ENSMUST00000225757.2 Gm47577 ENSMUST00000225757.2 Gm47577 (from geneSymbol) ENSMUST00000225757.1 LF199684 uc288pjo.1 uc288pjo.2 uc288pjo.1 uc288pjo.2 
ENSMUST00000225768.2 4933436N17Rik ENSMUST00000225768.2 4933436N17Rik (from geneSymbol) AK017089 ENSMUST00000225768.1 uc288mat.1 uc288mat.2 uc288mat.1 uc288mat.2 
ENSMUST00000225771.2 Gm48600 ENSMUST00000225771.2 Gm48600 (from geneSymbol) ENSMUST00000225771.1 uc288qti.1 uc288qti.2 uc288qti.1 uc288qti.2 
ENSMUST00000225772.2 Zfp458 ENSMUST00000225772.2 Zfp458 (from geneSymbol) BC062958 ENSMUST00000225772.1 Q7M6X6 Q7M6X6_MOUSE Zfp458 uc007ram.1 uc007ram.2 uc007ram.3 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc007ram.1 uc007ram.2 uc007ram.3 
ENSMUST00000225777.2 Gm48399 ENSMUST00000225777.2 Gm48399 (from geneSymbol) ENSMUST00000225777.1 uc288otu.1 uc288otu.2 uc288otu.1 uc288otu.2 
ENSMUST00000225792.2 Mbl1 ENSMUST00000225792.2 mannose-binding lectin (protein A) 1 (from RefSeq NM_010775.2) ENSMUST00000225792.1 MBL1_MOUSE NM_010775 P39039 Q0P6H1 uc007tcp.1 uc007tcp.2 uc007tcp.3 Calcium-dependent lectin. Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway (By similarity). Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). Homotrimer (By similarity). Forms higher oligomeric complexes formed by the association of two, three or more homotrimers (PubMed:25419660). Oligomerization occurs in the endoplasmic reticulum (By similarity). Interacts with MASP1 and MASP2 (By similarity). Secreted Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P39039-1; Sequence=Displayed; Name=2; IsoId=P39039-2; Sequence=VSP_038477; Detected in liver and blood serum (at protein level) (PubMed:1637828, PubMed:25419660). Detected in liver (PubMed:1712818). The helical collagen-like domains from three protein chains assemble into a coiled coil and mediate trimerization. Hydroxylated on lysine and proline residues within the collagen- like domain. O-glycosylated. O-linked glycans on hydroxylysine residues consist of Glc-Gal disaccharides bound to the oxygen atom of post- translationally added hydroxyl groups. [Isoform 2]: May be due to competing donor splice site. Name=Functional Glycomics Gateway - Glycan Binding; Note=Mannose-binding protein A; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_168"; lipopolysaccharide binding complement activation, lectin pathway protease binding immune system process calcium ion binding mannose binding extracellular region collagen trimer extracellular space multivesicular body rough endoplasmic reticulum complement activation, classical pathway carbohydrate binding polysaccharide binding developmental process protein homodimerization activity surfactant homeostasis innate immune response metal ion binding monosaccharide binding calcium-dependent protein binding positive regulation of phagocytosis defense response to Gram-positive bacterium protein homotetramerization killing by host of symbiont cells protein homotrimerization phosphatidylinositol-4-phosphate binding oligosaccharide binding uc007tcp.1 uc007tcp.2 uc007tcp.3 
ENSMUST00000225805.2 Nup58 ENSMUST00000225805.2 Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. (from UniProt Q8R332) AK029688 ENSMUST00000225805.1 NUP58_MOUSE Nup58 Nupl1 Q3UJF4 Q8BUA7 Q8BVG7 Q8C0W3 Q8R332 uc288uyq.1 uc288uyq.2 Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58. Interacts with NUTF2. Interacts with SRP1- alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone (By similarity). Q8R332-1; P63085: Mapk1; NbExp=3; IntAct=EBI-646962, EBI-397697; Nucleus, nuclear pore complex Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=p58; IsoId=Q8R332-1; Sequence=Displayed; Name=2; IsoId=Q8R332-2; Sequence=VSP_008573; Name=3; IsoId=Q8R332-3; Sequence=VSP_008574; Name=4; IsoId=Q8R332-4; Sequence=VSP_008575; Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. O-glycosylated. In rat, the p62 complex contains two different isoforms of NUP58. Isoform p45 has however not been isolated in mouse so far. Belongs to the NUP58 family. protein binding nucleus nuclear envelope nuclear pore nucleocytoplasmic transport nuclear localization sequence binding protein transport membrane structural constituent of nuclear pore nuclear membrane macromolecular complex regulation of protein import into nucleus mRNA transport protein homooligomerization protein heterotetramerization protein heterooligomerization protein heterotrimerization uc288uyq.1 uc288uyq.2 
ENSMUST00000225810.2 Gm48900 ENSMUST00000225810.2 Gm48900 (from geneSymbol) ENSMUST00000225810.1 uc288oer.1 uc288oer.2 uc288oer.1 uc288oer.2 
ENSMUST00000225812.3 Spin2-ps7 ENSMUST00000225812.3 Spin2-ps7 (from geneSymbol) ENSMUST00000225812.1 ENSMUST00000225812.2 uc292nqo.1 uc292nqo.2 uc292nqo.3 uc292nqo.1 uc292nqo.2 uc292nqo.3 
ENSMUST00000225817.2 Gm5464 ENSMUST00000225817.2 Gm5464 (from geneSymbol) AK078241 ENSMUST00000225817.1 uc288vhe.1 uc288vhe.2 uc288vhe.1 uc288vhe.2 
ENSMUST00000225819.3 Gm48163 ENSMUST00000225819.3 Gm48163 (from geneSymbol) ENSMUST00000225819.1 ENSMUST00000225819.2 uc288rak.1 uc288rak.2 uc288rak.3 uc288rak.1 uc288rak.2 uc288rak.3 
ENSMUST00000225828.2 Rmi1 ENSMUST00000225828.2 RecQ mediated genome instability 1, transcript variant 3 (from RefSeq NR_031761.1) ENSMUST00000225828.1 NR_031761 Q8C560 Q8CI20 Q9D4G9 RMI1_MOUSE uc007qua.1 uc007qua.2 uc007qua.3 uc007qua.4 Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A- mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity). Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM. Directly interacts with RMI2 and TOP3A. May bind DHJ. Interacts (via N-terminal region) with BLM; the interaction is direct (By similarity). Nucleus Note=Forms foci in response to DNA damage. Belongs to the RMI1 family. nucleotide binding resolution of meiotic recombination intermediates double-strand break repair via homologous recombination response to dietary excess reduction of food intake in response to dietary excess molecular_function nucleus nucleoplasm DNA replication response to glucose nuclear body RecQ helicase-Topo III complex multicellular organism growth glucose homeostasis uc007qua.1 uc007qua.2 uc007qua.3 uc007qua.4 
ENSMUST00000225832.3 Gm47850 ENSMUST00000225832.3 Gm47850 (from geneSymbol) AK085800 ENSMUST00000225832.1 ENSMUST00000225832.2 uc288pzq.1 uc288pzq.2 uc288pzq.3 uc288pzq.1 uc288pzq.2 uc288pzq.3 
ENSMUST00000225844.2 C130051F05Rik ENSMUST00000225844.2 C130051F05Rik (from geneSymbol) ENSMUST00000225844.1 LF199633 uc288otd.1 uc288otd.2 uc288otd.1 uc288otd.2 
ENSMUST00000225846.2 Gm49144 ENSMUST00000225846.2 Gm49144 (from geneSymbol) ENSMUST00000225846.1 uc288mbe.1 uc288mbe.2 uc288mbe.1 uc288mbe.2 
ENSMUST00000225848.2 Gm47918 ENSMUST00000225848.2 Gm47918 (from geneSymbol) ENSMUST00000225848.1 uc288ngw.1 uc288ngw.2 uc288ngw.1 uc288ngw.2 
ENSMUST00000225859.2 Gm49391 ENSMUST00000225859.2 Gm49391 (from geneSymbol) A0A286YD17 A0A286YD17_MOUSE AK150917 ENSMUST00000225859.1 Gm49391 uc288nmk.1 uc288nmk.2 uc288nmk.1 uc288nmk.2 
ENSMUST00000225867.2 Gm47423 ENSMUST00000225867.2 Gm47423 (from geneSymbol) ENSMUST00000225867.1 uc288nhp.1 uc288nhp.2 uc288nhp.1 uc288nhp.2 
ENSMUST00000225871.2 Gm49355 ENSMUST00000225871.2 Gm49355 (from geneSymbol) A0A286YCQ6 A0A286YCQ6_MOUSE AK076182 ENSMUST00000225871.1 Gm49355 uc288qtq.1 uc288qtq.2 uc288qtq.1 uc288qtq.2 
ENSMUST00000225876.3 Gm48321 ENSMUST00000225876.3 Gm48321 (from geneSymbol) AK041706 ENSMUST00000225876.1 ENSMUST00000225876.2 uc007shm.1 uc007shm.2 uc007shm.3 uc007shm.4 uc007shm.1 uc007shm.2 uc007shm.3 uc007shm.4 
ENSMUST00000225881.2 Gm21762 ENSMUST00000225881.2 Gm21762 (from geneSymbol) AK143258 D13Ertd608e ENSMUST00000225881.1 Gm21762 Q3UPR8 Q3UPR8_MOUSE uc029sdw.1 uc029sdw.2 uc029sdw.3 uc029sdw.1 uc029sdw.2 uc029sdw.3 
ENSMUST00000225886.2 Gm48707 ENSMUST00000225886.2 Gm48707 (from geneSymbol) ENSMUST00000225886.1 uc288lzn.1 uc288lzn.2 uc288lzn.1 uc288lzn.2 
ENSMUST00000225889.2 Gm47794 ENSMUST00000225889.2 Gm47794 (from geneSymbol) AK044606 ENSMUST00000225889.1 uc288raa.1 uc288raa.2 uc288raa.1 uc288raa.2 
ENSMUST00000225896.2 Top6bl ENSMUST00000225896.2 TOP6B like initiator of meiotic double strand breaks (from RefSeq NM_001033447.4) ENSMUST00000225896.1 Gm960 J3QMY9 NM_001033447 Q3UY62 TO6BL_MOUSE Top6bl uc289qdm.1 uc289qdm.2 Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Heterotetramer of SPO11 and 2 TOP6BL chains (Probable). Interacts with SPO11 (PubMed:26917764). J3QMY9; Q9WTK8-1: Spo11; NbExp=6; IntAct=EBI-16200997, EBI-16201014; Chromosome Note=Localizes to meiotic chromosomes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=J3QMY9-1; Sequence=Displayed; Name=2; IsoId=J3QMY9-2; Sequence=VSP_058336, VSP_058337; In males, expressed in testis but not in other tissues. Expressed in testis from 8 days postpartum (dpp) onward, with a peak of expression around 12 to 14 dpp, at the beginning of meiotic prophase. In females, expressed in embryonic ovaries when oocytes proceed through meiotic prophase (PubMed:26917764). Despite a weak sequence similarity, retains most of the structural features of the ancestral archaeal Top6B subunit (AC O05207), including the transducer domain that interacts with the SPO11 subunit and the ATP-binding fold, also named GHKL fold. Male mice develop normally and reach adulthood but have smaller testes. Spermatogonia are present at the periphery of tubules but are strongly depleted and spermatids are absent, due to defects during meiotic prophase. Belongs to the TOP6B-like family. DNA topoisomerase type II (ATP-hydrolyzing) activity protein binding cellular_component chromosome reciprocal meiotic recombination meiotic DNA double-strand break formation meiotic cell cycle uc289qdm.1 uc289qdm.2 
ENSMUST00000225900.2 Gm47272 ENSMUST00000225900.2 Gm47272 (from geneSymbol) ENSMUST00000225900.1 uc289pub.1 uc289pub.2 uc289pub.1 uc289pub.2 
ENSMUST00000225902.2 Gm49352 ENSMUST00000225902.2 Belongs to the peptidase C1 family. (from UniProt A0A286YCD0) A0A286YCD0 A0A286YCD0_MOUSE AF456463 ENSMUST00000225902.1 Gm49352 uc288nns.1 uc288nns.2 Belongs to the peptidase C1 family. cysteine-type endopeptidase activity extracellular space lysosome proteolysis cysteine-type peptidase activity proteolysis involved in cellular protein catabolic process uc288nns.1 uc288nns.2 
ENSMUST00000225905.2 Gm47429 ENSMUST00000225905.2 Gm47429 (from geneSymbol) A0A286YCQ8 A0A286YCQ8_MOUSE ENSMUST00000225905.1 Gm47429 uc288mtz.1 uc288mtz.2 uc288mtz.1 uc288mtz.2 
ENSMUST00000225907.2 Gm48267 ENSMUST00000225907.2 Gm48267 (from geneSymbol) ENSMUST00000225907.1 uc288quq.1 uc288quq.2 uc288quq.1 uc288quq.2 
ENSMUST00000225913.2 Gm41109 ENSMUST00000225913.2 Gm41109 (from geneSymbol) AK133148 ENSMUST00000225913.1 uc288roa.1 uc288roa.2 uc288roa.1 uc288roa.2 
ENSMUST00000225919.2 D030051J21Rik ENSMUST00000225919.2 D030051J21Rik (from geneSymbol) ENSMUST00000225919.1 uc288quf.1 uc288quf.2 uc288quf.1 uc288quf.2 
ENSMUST00000225920.2 Pcgf5 ENSMUST00000225920.2 polycomb group ring finger 5, transcript variant 3 (from RefSeq NM_001368692.1) B2RTD3 B7ZP23 ENSMUST00000225920.1 NM_001368692 PCGF5_MOUSE Q3UK78 Q9D3E5 Q9DCW8 Rnf159 uc008hhi.1 uc008hhi.2 uc008hhi.3 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:27136092, PubMed:28596365). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365). Component of a PRC1-like complex that contains PCGF5, RNF2 and UBE2D3 (PubMed:28596365). Interacts with RNF2; the interaction is direct (PubMed:27136092, PubMed:28596365). Interacts with CBX6, CBX7 and CBX8. Interacts with AUTS2; the interaction is direct. Identified in a complex that contains AUTS2, PCGF5, CSNK2B and RNF2 (By similarity). Nucleus Nucleus, nucleoplasm Note=Recruited by the non- coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UK78-1; Sequence=Displayed; Name=2; IsoId=Q3UK78-2; Sequence=VSP_023120; Detected in hematopoietic stem cells and multipotent progenitor cells. Combined disruption of both Pcgf3 and Pcgf5 causes embryonic lethality; there are no live progeny. Male embryos are detected at 9.5 and 10.5 dpc, but are smaller than normal. Female embryos are already extensively degraded at 9.5 dpc. Placentas from male embryos have some parietal trophoblast giant cells, but fail to form a labyrinth. Placentas from female embryos lack trophoblasts altogether and fail to form a labyrinth. Defects can be attributed to the observed lack of monoubiquitination of histone H2A 'Lys-119' and lack of Xist-mediated silencing of one copy of the X chromosome. Selective knockout in hematopoietic stem cells has only minor effects on gene expression and hematopoiesis, probably due to functional compensation by Pcgf1. Sequence=BAB22061.1; Type=Frameshift; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm nucleolus centrosome PcG protein complex PRC1 complex histone H2A-K119 monoubiquitination positive regulation of transcription from RNA polymerase II promoter metal ion binding inactivation of X chromosome by genetic imprinting X chromosome uc008hhi.1 uc008hhi.2 uc008hhi.3 
ENSMUST00000225930.3 2210404E10Rik ENSMUST00000225930.3 RIKEN cDNA 2210404E10 gene (from RefSeq NR_131163.1) ENSMUST00000225930.1 ENSMUST00000225930.2 NR_131163 uc008gqq.1 uc008gqq.2 uc008gqq.3 uc008gqq.4 uc008gqq.5 uc008gqq.1 uc008gqq.2 uc008gqq.3 uc008gqq.4 uc008gqq.5 
ENSMUST00000225931.2 Gm47694 ENSMUST00000225931.2 Gm47694 (from geneSymbol) AK132191 ENSMUST00000225931.1 uc288uys.1 uc288uys.2 uc288uys.1 uc288uys.2 
ENSMUST00000225935.3 Gm47734 ENSMUST00000225935.3 Gm47734 (from geneSymbol) ENSMUST00000225935.1 ENSMUST00000225935.2 uc288mbv.1 uc288mbv.2 uc288mbv.3 uc288mbv.1 uc288mbv.2 uc288mbv.3 
ENSMUST00000225951.2 Cenpj ENSMUST00000225951.2 centromere protein J, transcript variant 2 (from RefSeq NM_001403533.1) CENPJ_MOUSE E9QLP3 ENSMUST00000225951.1 NM_001403533 Q569L8 uc288utj.1 uc288utj.2 Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (By similarity). Forms homodimers. Associates with microtubules plus ends; binds to beta-tubulin subunits exposed on microtubule outer surface at its distal tip; also associates with microtubule lattice. Associated with the gamma-tubulin complex. Interacts with the head domain of EPB41. Interacts with LYST. Interacts with CEP152 (via C-terminus). Interacts with STIL. Forms a complex with STIL and SASS6 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localized within the center of microtubule asters. During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles (By similarity). Phosphorylation at Ser-577 and Ser-583 by PLK2 is required for procentriole formation and centriole elongation. Phosphorylation by PLK2 oscillates during the cell cycle: it increases at G1/S transition and decreases during the exit from mitosis. Phosphorylation at Ser-583 is also mediated by PLK4 but is not a critical step in PLK4 function in procentriole assembly. Belongs to the TCP10 family. transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm cytoplasm centrosome centriole microtubule organizing center cytoskeleton microtubule plasma membrane centriole replication smoothened signaling pathway tubulin binding protein kinase binding protein domain specific binding astral microtubule nucleation ciliary basal body identical protein binding gamma-tubulin binding motile cilium assembly positive regulation of JAK-STAT cascade regulation of centriole replication microtubule polymerization centrosome duplication cell division centriole elongation centriole assembly positive regulation of non-motile cilium assembly mitotic spindle pole body duplication negative regulation of nucleic acid-templated transcription positive regulation of nucleic acid-templated transcription positive regulation of centriole elongation positive regulation of establishment of protein localization non-motile cilium assembly uc288utj.1 uc288utj.2 
ENSMUST00000225967.2 Gm48571 ENSMUST00000225967.2 Gm48571 (from geneSymbol) ENSMUST00000225967.1 uc288mhv.1 uc288mhv.2 uc288mhv.1 uc288mhv.2 
ENSMUST00000225970.2 2310067P03Rik ENSMUST00000225970.2 2310067P03Rik (from geneSymbol) AK010100 ENSMUST00000225970.1 uc288owk.1 uc288owk.2 uc288owk.1 uc288owk.2 
ENSMUST00000225976.3 Gm48058 ENSMUST00000225976.3 Gm48058 (from geneSymbol) ENSMUST00000225976.1 ENSMUST00000225976.2 uc288rux.1 uc288rux.2 uc288rux.3 uc288rux.1 uc288rux.2 uc288rux.3 
ENSMUST00000225980.2 Atp9b ENSMUST00000225980.2 ATPase, class II, type 9B, transcript variant 2 (from RefSeq NM_015805.3) A0A286YCV0 A0A286YCV0_MOUSE Atp9b ENSMUST00000225980.1 NM_015805 uc008fth.1 uc008fth.2 uc008fth.3 uc008fth.4 Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Membrane ulti-pass membrane protein Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. nucleotide binding magnesium ion binding ATP binding trans-Golgi network phospholipid transport membrane integral component of membrane perinuclear region of cytoplasm uc008fth.1 uc008fth.2 uc008fth.3 uc008fth.4 
ENSMUST00000225983.2 Gm47758 ENSMUST00000225983.2 Gm47758 (from geneSymbol) ENSMUST00000225983.1 uc288qza.1 uc288qza.2 uc288qza.1 uc288qza.2 
ENSMUST00000225984.2 A930015P04Rik ENSMUST00000225984.2 A930015P04Rik (from geneSymbol) AK020865 ENSMUST00000225984.1 uc288nje.1 uc288nje.2 uc288nje.1 uc288nje.2 
ENSMUST00000225988.2 Gm48192 ENSMUST00000225988.2 Gm48192 (from geneSymbol) AK087646 ENSMUST00000225988.1 uc288mgw.1 uc288mgw.2 uc288mgw.1 uc288mgw.2 
ENSMUST00000226034.2 Gm40828 ENSMUST00000226034.2 Gm40828 (from geneSymbol) ENSMUST00000226034.1 uc288let.1 uc288let.2 uc288let.1 uc288let.2 
ENSMUST00000226039.2 Trim38 ENSMUST00000226039.2 E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:22539786, PubMed:26392463, PubMed:27637147). Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (PubMed:22539786). Mediates 'Lys- 48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:26392463). Acts as a positive regulator of the cGAS- STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (PubMed:27637147). Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (By similarity). (from UniProt Q5SZ99) B9EKD3 BC150836 ENSMUST00000226039.1 Q5SZ99 TRI38_MOUSE Trim38 uc288lml.1 uc288lml.2 E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:22539786, PubMed:26392463, PubMed:27637147). Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (PubMed:22539786). Mediates 'Lys- 48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:26392463). Acts as a positive regulator of the cGAS- STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (PubMed:27637147). Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (By similarity). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence= Protein modification; protein ubiquitination. Protein modification; protein sumoylation. Interacts (via B30.2/SPRY domain) with TAB2 and TAB3. Cytoplasm Mice are more susceptible to death triggered by polyinosinic:polycytidylic acid, LPS and S.typhimurium (PubMed:26392463). Increased TLR3/4-mediated cytokine induction (PubMed:26392463). protein binding cellular_component zinc ion binding regulation of interferon-beta production positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of viral genome replication positive regulation of viral entry into host cell metal ion binding negative regulation of defense response to virus positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein K48-linked ubiquitination uc288lml.1 uc288lml.2 
ENSMUST00000226065.2 Gm47348 ENSMUST00000226065.2 Gm47348 (from geneSymbol) ENSMUST00000226065.1 uc288mfk.1 uc288mfk.2 uc288mfk.1 uc288mfk.2 
ENSMUST00000226068.2 Myof ENSMUST00000226068.2 myoferlin, transcript variant 1 (from RefSeq NM_001302140.1) A0A286YDF5 A0A286YDF5_MOUSE ENSMUST00000226068.1 Myof NM_001302140 uc012blf.1 uc012blf.2 uc012blf.3 The protein encoded by this gene is a member of the ferlin family of proteins, which have been implicated in fusion events in muscle tissue. Members of this family have a carboxy-terminal single pass transmembrane domain and multiple C2 domains, which bind negatively charged phospholipids in the presence of calcium ions. This gene is expressed at high levels in myoblasts and upregulated in damaged skeletal muscle. Mice deficient in this protein display defects in myoblast fusion, muscle regeneration, and angiogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. Cytoplasmic vesicle membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Belongs to the ferlin family. myoblast fusion membrane integral component of membrane uc012blf.1 uc012blf.2 uc012blf.3 
ENSMUST00000226075.2 Hand2os1 ENSMUST00000226075.2 Hand2os1 (from geneSymbol) ENSMUST00000226075.1 uc291zzf.1 uc291zzf.2 uc291zzf.1 uc291zzf.2 
ENSMUST00000226077.2 Gm47756 ENSMUST00000226077.2 Gm47756 (from geneSymbol) AK156049 ENSMUST00000226077.1 uc288qyz.1 uc288qyz.2 uc288qyz.1 uc288qyz.2 
ENSMUST00000226078.2 Gm47189 ENSMUST00000226078.2 predicted gene, 47189 (from RefSeq NM_001384240.1) A0A286YDG0 A0A286YDG0_MOUSE ENSMUST00000226078.1 Gm47189 NM_001384240 uc288soj.1 uc288soj.2 uc288soj.1 uc288soj.2 
ENSMUST00000226087.2 Adgrf5 ENSMUST00000226087.2 adhesion G protein-coupled receptor F5, transcript variant 7 (from RefSeq NM_001404546.1) AGRF5_MOUSE ENSMUST00000226087.1 G5E8Q8 Gpr116 NM_001404546 uc289lfr.1 uc289lfr.2 Receptor that plays a critical role in lung surfactant homeostasis (PubMed:23590306, PubMed:23922714, PubMed:23684610). May play a role in controlling adipocyte function (PubMed:22971422). Homodimer; disulfide-linked. Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Fragment generates by the processing enzyme furin remains attached to the extracellular N- terminal fragment. Interacts (via N-terminal extracellular domain) with SFTPD (PubMed:23922714). Cell membrane ; Multi-pass membrane protein Widely expressed and highly expressed in the lung. In the lung predominantly expressed in the alveolar type II epithelial cells. Proteolytically cleaved at multiple sites: one in the GPS domain (S1 site) and the other in the SEA domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven- transmembrane subunit. The proteolytic cleavage at S2 site generates a fragment that undergoes proteolytic cleavage by the processing enzyme furin. Highly glycosylated. Deficient mice exhibit premature death, decreased body weight and respiratory distress associated with pulmonary alveolar proteinosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. glomerular filtration molecular_function transmembrane signaling receptor activity G-protein coupled receptor activity plasma membrane energy reserve metabolic process cell surface receptor signaling pathway G-protein coupled receptor signaling pathway cell surface membrane integral component of membrane regulation of lipid metabolic process cytoplasmic vesicle glucose homeostasis negative regulation of macrophage activation surfactant homeostasis apical part of cell fat cell differentiation erythrocyte development pharyngeal arch artery morphogenesis positive regulation of phospholipid biosynthetic process uc289lfr.1 uc289lfr.2 
ENSMUST00000226101.2 Gm48703 ENSMUST00000226101.2 Gm48703 (from geneSymbol) ENSMUST00000226101.1 uc288lzk.1 uc288lzk.2 uc288lzk.1 uc288lzk.2 
ENSMUST00000226102.2 Gm48194 ENSMUST00000226102.2 Gm48194 (from geneSymbol) ENSMUST00000226102.1 uc288nku.1 uc288nku.2 uc288nku.1 uc288nku.2 
ENSMUST00000226104.3 Gm47730 ENSMUST00000226104.3 Gm47730 (from geneSymbol) ENSMUST00000226104.1 ENSMUST00000226104.2 uc288mbr.1 uc288mbr.2 uc288mbr.3 uc288mbr.1 uc288mbr.2 uc288mbr.3 
ENSMUST00000226106.2 Gm47243 ENSMUST00000226106.2 Gm47243 (from geneSymbol) ENSMUST00000226106.1 uc289rcf.1 uc289rcf.2 uc289rcf.1 uc289rcf.2 
ENSMUST00000226118.3 Gm49113 ENSMUST00000226118.3 Gm49113 (from geneSymbol) ENSMUST00000226118.1 ENSMUST00000226118.2 uc288xcd.1 uc288xcd.2 uc288xcd.3 uc288xcd.1 uc288xcd.2 uc288xcd.3 
ENSMUST00000226119.2 Ctnnd2 ENSMUST00000226119.2 catenin delta 2, transcript variant 4 (from RefSeq NM_001411453.1) B7ZNF6 B7ZNF6_MOUSE Ctnnd2 ENSMUST00000226119.1 NM_001411453 uc011zrs.1 uc011zrs.2 uc011zrs.3 uc011zrs.4 Belongs to the beta-catenin family. cell-cell adhesion uc011zrs.1 uc011zrs.2 uc011zrs.3 uc011zrs.4 
ENSMUST00000226121.2 4930524C18Rik ENSMUST00000226121.2 RIKEN cDNA 4930524C18 gene (from RefSeq NR_045661.1) ENSMUST00000226121.1 NR_045661 uc029smy.1 uc029smy.2 uc029smy.1 uc029smy.2 
ENSMUST00000226135.2 5830426I08Rik ENSMUST00000226135.2 5830426I08Rik (from geneSymbol) AK020019 ENSMUST00000226135.1 uc288xfq.1 uc288xfq.2 uc288xfq.1 uc288xfq.2 
ENSMUST00000226138.2 5430430K15Rik ENSMUST00000226138.2 5430430K15Rik (from geneSymbol) AK017366 ENSMUST00000226138.1 uc288ufw.1 uc288ufw.2 uc288ufw.1 uc288ufw.2 
ENSMUST00000226140.2 Gm49199 ENSMUST00000226140.2 Gm49199 (from geneSymbol) AK155837 ENSMUST00000226140.1 uc288vzo.1 uc288vzo.2 uc288vzo.1 uc288vzo.2 
ENSMUST00000226145.2 Otulinl ENSMUST00000226145.2 OTU deubiquitinase with linear linkage specificity like, transcript variant 6 (from RefSeq NR_183254.1) ENSMUST00000226145.1 Fam105a NR_183254 OTULL_MOUSE Otulinl Q3TVP5 Q3U8Q4 Q80WP7 uc007vju.1 uc007vju.2 uc007vju.3 uc007vju.4 Lacks deubiquitinase activity. Does not bind ubiquitin or ubiquitin-like proteins. Cytoplasm Endoplasmic reticulum membrane ; Peripheral membrane protein Nucleus envelope Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TVP5-1; Sequence=Displayed; Name=2; IsoId=Q3TVP5-2; Sequence=VSP_022738; The N-terminal region that precedes the OTU domain mediates interaction with cellular membranes. Belongs to the peptidase C65 family. Otulin subfamily. Although highly similar to the deubiquitinase OTULIN, lacks the conserved active site Cys at position 136 which is replaced by an Asp residue, and does not show deubiquitinase activity. molecular_function nucleus nuclear envelope cytoplasm endoplasmic reticulum endoplasmic reticulum membrane proteolysis biological_process membrane extrinsic component of endoplasmic reticulum membrane protein deubiquitination ubiquitin-like protein-specific protease activity ubiquitin binding uc007vju.1 uc007vju.2 uc007vju.3 uc007vju.4 
ENSMUST00000226148.3 Gm49217 ENSMUST00000226148.3 Gm49217 (from geneSymbol) ENSMUST00000226148.1 ENSMUST00000226148.2 uc288sck.1 uc288sck.2 uc288sck.3 uc288sck.1 uc288sck.2 uc288sck.3 
ENSMUST00000226159.2 Gm49010 ENSMUST00000226159.2 Gm49010 (from geneSymbol) ENSMUST00000226159.1 uc288wkw.1 uc288wkw.2 uc288wkw.1 uc288wkw.2 
ENSMUST00000226173.2 Gm48910 ENSMUST00000226173.2 Gm48910 (from geneSymbol) ENSMUST00000226173.1 uc288tbh.1 uc288tbh.2 uc288tbh.1 uc288tbh.2 
ENSMUST00000226187.2 Gm32913 ENSMUST00000226187.2 Gm32913 (from geneSymbol) ENSMUST00000226187.1 uc288vyy.1 uc288vyy.2 uc288vyy.1 uc288vyy.2 
ENSMUST00000226194.2 Rnase6 ENSMUST00000226194.2 ribonuclease, RNase A family, 6, transcript variant 2 (from RefSeq NM_001360117.1) ENSMUST00000226194.1 NM_001360117 Q3V3L3 Q3V3L3_MOUSE Rnase6 uc007tmr.1 uc007tmr.2 uc007tmr.3 uc007tmr.4 uc007tmr.5 Interacts (via N-terminus) with bacterial lipopolysaccharide (LPS). Cytoplasmic granule Lysosome Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity ribonuclease activity extracellular space hydrolase activity antibacterial humoral response cytoplasmic vesicle innate immune response defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to virus RNA phosphodiester bond hydrolysis uc007tmr.1 uc007tmr.2 uc007tmr.3 uc007tmr.4 uc007tmr.5 
ENSMUST00000226195.3 4930434J06Rik ENSMUST00000226195.3 4930434J06Rik (from geneSymbol) AK015316 ENSMUST00000226195.1 ENSMUST00000226195.2 uc288vof.1 uc288vof.2 uc288vof.3 uc288vof.1 uc288vof.2 uc288vof.3 
ENSMUST00000226198.2 Vmn1r2 ENSMUST00000226198.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2AMT6) A2AMT6 A2AMT6_MOUSE ENSMUST00000226198.1 Vmn1r2 uc290kyc.1 uc290kyc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc290kyc.1 uc290kyc.2 
ENSMUST00000226208.3 Zfand3 ENSMUST00000226208.3 zinc finger, AN1-type domain 3, transcript variant 2 (from RefSeq NM_001356265.1) ENSMUST00000226208.1 ENSMUST00000226208.2 NM_001356265 Q497H0 Q8K230 Q8R2V7 Q8R3V1 Tex27 ZFAN3_MOUSE uc008btq.1 uc008btq.2 uc008btq.3 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q497H0-1; Sequence=Displayed; Name=2; IsoId=Q497H0-2; Sequence=VSP_017154; Expressed in testis. Preferentially expressed during the haploid stages of spermatogenesis. Sequence=AAH27161.1; Type=Erroneous initiation; Evidence=; DNA binding cellular_component biological_process zinc ion binding metal ion binding uc008btq.1 uc008btq.2 uc008btq.3 
ENSMUST00000226212.2 ENSMUSG00000121466 ENSMUST00000226212.2 ENSMUSG00000121466 (from geneSymbol) ENSMUST00000226212.1 uc288tov.1 uc288tov.2 uc288tov.1 uc288tov.2 
ENSMUST00000226216.2 4930544F09Rik ENSMUST00000226216.2 4930544F09Rik (from geneSymbol) AK016034 ENSMUST00000226216.1 uc288yfm.1 uc288yfm.2 uc288yfm.1 uc288yfm.2 
ENSMUST00000226218.2 Gm49188 ENSMUST00000226218.2 Gm49188 (from geneSymbol) ENSMUST00000226218.1 uc288xmk.1 uc288xmk.2 uc288xmk.1 uc288xmk.2 
ENSMUST00000226227.2 Gm4681 ENSMUST00000226227.2 Gm4681 (from geneSymbol) AK038711 ENSMUST00000226227.1 uc007uzp.1 uc007uzp.2 uc007uzp.1 uc007uzp.2 
ENSMUST00000226228.2 Vmn1r69 ENSMUST00000226228.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VIC1) ENSMUST00000226228.1 H3BJH9 Q8VIC1 Q8VIC1_MOUSE V1RE6 V1re2 V1re9 Vmn1r69 uc291lil.1 uc291lil.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lil.1 uc291lil.2 
ENSMUST00000226230.2 Gm49166 ENSMUST00000226230.2 Gm49166 (from geneSymbol) ENSMUST00000226230.1 uc288xdt.1 uc288xdt.2 uc288xdt.1 uc288xdt.2 
ENSMUST00000226232.2 App ENSMUST00000226232.2 amyloid beta precursor protein, transcript variant 3 (from RefSeq NM_001198824.1) A0A2I3BQZ9 A0A2I3BQZ9_MOUSE App ENSMUST00000226232.1 NM_001198824 uc007ztp.1 uc007ztp.2 uc007ztp.3 uc007ztp.4 Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. Cell membrane ; Single-pass type I membrane protein Cell projection, growth cone Cell surface Cytoplasmic vesicle Early endosome Endosome Golgi apparatus Membrane, clathrin-coated pit Membrane ; Single-pass type I membrane protein Perikaryon Vesicle Belongs to the APP family. Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase inhibitor activity nervous system development heparin binding negative regulation of endopeptidase activity membrane integral component of membrane transition metal ion binding uc007ztp.1 uc007ztp.2 uc007ztp.3 uc007ztp.4 
ENSMUST00000226251.2 1810028F09Rik ENSMUST00000226251.2 1810028F09Rik (from geneSymbol) AK007949 ENSMUST00000226251.1 uc288tok.1 uc288tok.2 uc288tok.1 uc288tok.2 
ENSMUST00000226255.2 Vmn1r70 ENSMUST00000226255.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R254) ENSMUST00000226255.1 Q8R254 Q8R254_MOUSE V1rl1 Vmn1r70 uc291lit.1 uc291lit.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lit.1 uc291lit.2 
ENSMUST00000226263.2 Gm49283 ENSMUST00000226263.2 Gm49283 (from geneSymbol) ENSMUST00000226263.1 uc288xiz.1 uc288xiz.2 uc288xiz.1 uc288xiz.2 
ENSMUST00000226280.2 Cma1 ENSMUST00000226280.2 chymase 1, mast cell (from RefSeq NM_010780.3) CMA1_MOUSE ENSMUST00000226280.1 Mcpt5 NM_010780 P21844 Q9R1F0 uc007ubf.1 uc007ubf.2 uc007ubf.3 uc007ubf.4 This gene encodes a serine protease that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. The encoded preproprotein undergoes proteolytic processing to generate a functional enzyme with elastase-like activity. Mice lacking the encoded protein exhibit significant attenuation of ischemia-reperfusion injury of the skeletal muscle. This gene is located in a cluster of related mast cell protease genes on chromosome 14. [provided by RefSeq, Nov 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X68805.1, M73759.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Reaction=Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.; EC=3.4.21.39; Secreted Cytoplasmic granule Note=Secretory granules. Mast cells. Belongs to the peptidase S1 family. Granzyme subfamily. Sequence=CAA48705.1; Type=Erroneous initiation; Evidence=; serine-type endopeptidase activity extracellular region extracellular space cytoplasm proteolysis peptidase activity serine-type peptidase activity hydrolase activity extracellular matrix disassembly secretory granule basement membrane disassembly peptide binding positive regulation of angiogenesis interleukin-1 beta biosynthetic process uc007ubf.1 uc007ubf.2 uc007ubf.3 uc007ubf.4 
ENSMUST00000226284.2 Tsc2 ENSMUST00000226284.2 TSC complex subunit 2, transcript variant 1 (from RefSeq NM_011647.4) A0A2I3BPP1 A0A2I3BPP1_MOUSE ENSMUST00000226284.1 NM_011647 Tsc2 uc008awz.1 uc008awz.2 uc008awz.3 GTPase activator activity nucleus negative regulation of TOR signaling TSC1-TSC2 complex positive regulation of GTPase activity regulation of small GTPase mediated signal transduction uc008awz.1 uc008awz.2 uc008awz.3 
ENSMUST00000226288.2 Fam237a ENSMUST00000226288.2 family with sequence similarity 237, member A (from RefSeq NM_001370842.1) A0A1Z4VJI9 A0A1Z4VJI9_MOUSE ENSMUST00000226288.1 Fam237a Gm39653 NM_001370842 uc057kfs.1 uc057kfs.2 uc057kfs.3 uc057kfs.1 uc057kfs.2 uc057kfs.3 
ENSMUST00000226294.2 Vmn1r210 ENSMUST00000226294.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R274) ENSMUST00000226294.1 Q8R274 Q8R274_MOUSE V1rh10 Vmn1r210 uc288ljm.1 uc288ljm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288ljm.1 uc288ljm.2 
ENSMUST00000226296.3 Gm33246 ENSMUST00000226296.3 Gm33246 (from geneSymbol) ENSMUST00000226296.1 ENSMUST00000226296.2 uc288was.1 uc288was.2 uc288was.3 uc288was.1 uc288was.2 uc288was.3 
ENSMUST00000226299.2 Atg14 ENSMUST00000226299.2 Required for both basal and inducible autophagy (PubMed:19270696, PubMed:19270693). Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (By similarity). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:19270693). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (By similarity). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (By similarity). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation of PIK3C3 by AMPK (PubMed:23332761). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (By similarity). Modulates the hepatic lipid metabolism (PubMed:22992773). (from UniProt Q8CDJ3) Atg14 Atg14L BAKOR_MOUSE BC090995 D14Ertd436e ENSMUST00000226299.1 Kiaa0831 Q69ZY1 Q6PFY6 Q8C6N0 Q8CDJ3 Q8R3M3 uc007tik.1 uc007tik.2 uc007tik.3 uc007tik.4 Required for both basal and inducible autophagy (PubMed:19270696, PubMed:19270693). Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (By similarity). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:19270693). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (By similarity). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (By similarity). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation of PIK3C3 by AMPK (PubMed:23332761). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (By similarity). Modulates the hepatic lipid metabolism (PubMed:22992773). Forms homooligomers; homo-oligomerization is essential for the roles in membrane tethering and enhancement of SNARE-mediated fusion (By similarity). Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex I (PI3KC3-C1) in which the core composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 is associated with ATG14 (PubMed:19270693, PubMed:22745922, PubMed:23332761). PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex (By similarity). PI3KC3-C1 can associate with further regulatory subunits (PubMed:24849286). Interacts with PIK3CB (PubMed:21059846). Interacts (via coiled-coil domain) with BECN2 (via coiled-coil domain); this interaction is tighter than BECN2 self- association (By similarity). Interacts with the STX17-SNAP29 binary t- SNARE complex (By similarity). Interacts with NRBF2 (PubMed:24849286) Interacts with PIK3C3 and BECN1; this interaction is increased in the absence of TMEM39A (By similarity). Interacts with STEEP1; the interaction is required for trafficking of STING1 from the endoplasmic reticulum (By similarity). Interacts with ARMC3 (via ARM domains) (PubMed:34428398). Q8CDJ3; P23242: Gja1; NbExp=2; IntAct=EBI-3506699, EBI-298630; Q8CDJ3; Q8VCQ3: Nrbf2; NbExp=7; IntAct=EBI-3506699, EBI-2365563; Cytoplasm Endoplasmic reticulum membrane ; Peripheral membrane protein Preautophagosomal structure membrane eripheral membrane protein Cytoplasmic vesicle, autophagosome membrane ; Peripheral membrane protein Note=Cytosolic under nutrient-rich conditions (PubMed:20639694). Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes (PubMed:20639694). Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (PubMed:21518905). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (PubMed:24089209). Widely expressed. Expression is controlled by forkhead box O FoxO1 transcription factor and circadian rhythms. The coiled-coil domain is required for BECN1- and PIK3C3- binding and for autophagy. The final 80 residues in the C-terminus define a minimum required region for autophagosome binding called BATS. The N-terminal cysteine repeats are required for proper localization to the endoplasmic reticulum. Ubiquitinated via 'Lys-6', 'Lys-11' and 'Lys-63'-linked polyubiquitin chains on multiple lysines by MARCHF7, leading to ATG14 aggregation and loss of interaction with STX17. Belongs to the ATG14 family. autophagosome assembly autophagosome membrane macromitophagy regulation of protein phosphorylation negative regulation of protein phosphorylation positive regulation of protein phosphorylation protein binding cytoplasm autophagosome endoplasmic reticulum endoplasmic reticulum membrane axoneme autophagy endosome to lysosome transport cellular response to starvation posttranscriptional regulation of gene expression membrane macroautophagy autophagosome docking cytoplasmic vesicle pre-autophagosomal structure membrane phosphatidylinositol 3-kinase complex, class III cellular response to glucose starvation positive regulation of phosphatidylinositol 3-kinase activity ER-mitochondrion membrane contact site phagocytic vesicle GTPase binding regulation of triglyceride metabolic process extrinsic component of omegasome membrane extrinsic component of pre-autophagosomal structure membrane response to mitochondrial depolarisation uc007tik.1 uc007tik.2 uc007tik.3 uc007tik.4 
ENSMUST00000226305.2 4930474N05Rik ENSMUST00000226305.2 RIKEN cDNA 4930474N05 gene (from RefSeq NM_175008.3) 4930474N05Rik ENSMUST00000226305.1 NM_175008 Q8BVR5 Q8BVR5_MOUSE uc007tbl.1 uc007tbl.2 uc007tbl.3 hematopoietic progenitor cell differentiation molecular_function guanyl-nucleotide exchange factor activity cellular_component uc007tbl.1 uc007tbl.2 uc007tbl.3 
ENSMUST00000226306.2 ENSMUSG00000121701 ENSMUST00000226306.2 ENSMUSG00000121701 (from geneSymbol) ENSMUST00000226306.1 uc288vuj.1 uc288vuj.2 uc288vuj.1 uc288vuj.2 
ENSMUST00000226322.2 Gm48932 ENSMUST00000226322.2 Gm48932 (from geneSymbol) AK158951 ENSMUST00000226322.1 uc288xmy.1 uc288xmy.2 uc288xmy.1 uc288xmy.2 
ENSMUST00000226326.3 Gm49191 ENSMUST00000226326.3 Gm49191 (from geneSymbol) ENSMUST00000226326.1 ENSMUST00000226326.2 uc288xev.1 uc288xev.2 uc288xev.3 uc288xev.1 uc288xev.2 uc288xev.3 
ENSMUST00000226327.2 ENSMUSG00000121713 ENSMUST00000226327.2 ENSMUSG00000121713 (from geneSymbol) ENSMUST00000226327.1 uc288wag.1 uc288wag.2 uc288wag.1 uc288wag.2 
ENSMUST00000226330.2 Vmn1r201 ENSMUST00000226330.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R262) ENSMUST00000226330.1 Q8R262 Q8R262_MOUSE V1ri4 Vmn1r201 uc288lio.1 uc288lio.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lio.1 uc288lio.2 
ENSMUST00000226343.3 Gm35496 ENSMUST00000226343.3 predicted gene, 35496 (from RefSeq NR_155419.1) ENSMUST00000226343.1 ENSMUST00000226343.2 NR_155419 uc029sob.1 uc029sob.2 uc029sob.3 uc029sob.4 uc029sob.1 uc029sob.2 uc029sob.3 uc029sob.4 
ENSMUST00000226346.2 Gm10366 ENSMUST00000226346.2 Gm10366 (from geneSymbol) ENSMUST00000226346.1 LF199954 uc288ufy.1 uc288ufy.2 uc288ufy.1 uc288ufy.2 
ENSMUST00000226350.2 Gm35909 ENSMUST00000226350.2 Gm35909 (from geneSymbol) AK141462 ENSMUST00000226350.1 uc288wij.1 uc288wij.2 uc288wij.1 uc288wij.2 
ENSMUST00000226359.2 Gm49192 ENSMUST00000226359.2 Gm49192 (from geneSymbol) ENSMUST00000226359.1 uc288tav.1 uc288tav.2 uc288tav.1 uc288tav.2 
ENSMUST00000226360.3 Gm41148 ENSMUST00000226360.3 Gm41148 (from geneSymbol) ENSMUST00000226360.1 ENSMUST00000226360.2 uc288tfp.1 uc288tfp.2 uc288tfp.3 uc288tfp.1 uc288tfp.2 uc288tfp.3 
ENSMUST00000226368.2 Vmn1r49 ENSMUST00000226368.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (from UniProt Q9WUF1) ENSMUST00000226368.1 Q9WUF1 V1R49_MOUSE V1rb2 uc291gzl.1 uc291gzl.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Cell membrane ; Multi-pass membrane protein Expressed in a subset of sensory neurons located in the apical layer of the vomeronasal organ. Mice show a disrupted pattern of axonal projections to the accessory olfactory bulb. Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291gzl.1 uc291gzl.2 
ENSMUST00000226372.2 Gm48965 ENSMUST00000226372.2 Gm48965 (from geneSymbol) AK143601 ENSMUST00000226372.1 uc288xnu.1 uc288xnu.2 uc288xnu.1 uc288xnu.2 
ENSMUST00000226380.3 Gm33203 ENSMUST00000226380.3 Gm33203 (from geneSymbol) ENSMUST00000226380.1 ENSMUST00000226380.2 uc288wac.1 uc288wac.2 uc288wac.3 uc288wac.1 uc288wac.2 uc288wac.3 
ENSMUST00000226391.2 Gm49165 ENSMUST00000226391.2 Gm49165 (from geneSymbol) AK158291 ENSMUST00000226391.1 uc007upz.1 uc007upz.2 uc007upz.1 uc007upz.2 
ENSMUST00000226414.2 Ubr5 ENSMUST00000226414.2 ubiquitin protein ligase E3 component n-recognin 5, transcript variant 1 (from RefSeq NM_001081359.3) A0A2I3BQS6 A0A2I3BQS6_MOUSE ENSMUST00000226414.1 NM_001081359 Ubr5 uc007vno.1 uc007vno.2 uc007vno.3 uc007vno.4 Protein modification; protein ubiquitination. protein polyubiquitination RNA binding ubiquitin-protein transferase activity nucleus nucleoplasm cytosol cellular response to DNA damage stimulus zinc ion binding positive regulation of gene expression transferase activity macromolecular complex ubiquitin-ubiquitin ligase activity positive regulation of protein import into nucleus ubiquitin binding perinuclear region of cytoplasm progesterone receptor signaling pathway ubiquitin protein ligase activity protein K48-linked ubiquitination positive regulation of canonical Wnt signaling pathway negative regulation of histone H2A K63-linked ubiquitination negative regulation of double-strand break repair uc007vno.1 uc007vno.2 uc007vno.3 uc007vno.4 
ENSMUST00000226420.2 Rmrp ENSMUST00000226420.2 Rmrp (from geneSymbol) DM176433 ENSMUST00000226420.1 uc008spx.1 uc008spx.2 uc008spx.3 uc008spx.1 uc008spx.2 uc008spx.3 
ENSMUST00000226429.2 ENSMUSG00000121734 ENSMUST00000226429.2 ENSMUSG00000121734 (from geneSymbol) ENSMUST00000226429.1 uc288taa.1 uc288taa.2 uc288taa.1 uc288taa.2 
ENSMUST00000226440.3 Baalc ENSMUST00000226440.3 brain and acute leukemia, cytoplasmic (from RefSeq NM_080640.6) A9JR49 BAALC_MOUSE ENSMUST00000226440.1 ENSMUST00000226440.2 NM_080640 Q8VBS8 Q8VHV1 Q9CYS9 uc288xtv.1 uc288xtv.2 May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A. Interacts with CAMK2A. Cytoplasm Synapse, synaptosome Membrane raft Postsynaptic density Note=In neurons, localizes to postsynaptic lipid rafts (By similarity). In myocardial and skeletal muscle cells, localizes to the cytoplasm adjacent to the inner cell membrane, polarized to one end of the myocyte (PubMed:15749074). Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=1-6-8; IsoId=Q8VHV1-1; Sequence=Displayed; Name=2; Synonyms=1-8; IsoId=Q8VHV1-2; Sequence=VSP_020206; Name=3; IsoId=Q8VHV1-3; Sequence=VSP_020205; At the mRNA level, predominantly expressed in the brain (PubMed:11707601). At the protein level, mainly expressed in muscle tissues. In skeletal muscles, expressed in cranial and facial muscles, muscles of the neck, back, thoracic wall, and thigh. Also found in the contractile myoepithelial cell layer of salivary glands. In smooth muscles, expressed in the gastric wall, uterus, urinary bladder, as well as in the muscular lining around seminiferous tubules, prostatic ducts, epididymis, vas deferens, walls of small blood vessels in the dermis, and fascial layers between muscle fibers, brain, and around the spinal cord. Strongly expressed in myocardium. High expression levels are observed in placental spongiotrophoblast and adjacent myometrium. Also expressed in bone marrow hematopoietic cells. In the mature thymus, expressed in rare scattered cells. Weakly expressed in the brain neuropil, particularly near the hippocampus, and spinal cord white matter. Not detected in skin keratinocytes or lung (at protein level) (PubMed:15749074). During embryonic development, prominently expressed in muscle tissues, including myocardium, skeletal and smooth muscles, and weakly in the developing central nervous system (only in the neuropil). At 9 dpc, expressed in the wall and trabeculae of the developing heart tube, in the caudal end of the midline dorsal aorta, and a focal area of the mesenchyme around the developing brain. Weakly expressed in marginal and ependymal layers of the early neural tube. At 11-12.5 dpc, expression persists in the myocardium. Scattered signal in the mesoderm on either side of the developing neural tube. Also found in the region of dermatomyotomes. Appears to be associated with the early pre-muscle mesoderm and later with myoblasts and myocytes of the paravertebral, back, body wall and limb muscles. At 13-15 dpc, besides the myocardium, expression is seen in the skeletal muscles of the limbs, intercostal muscles, and the diaphragm, as well as in the developing muscle layer in the wall of the few intestinal coils present in the abdominal cavity. Also found in various components of the mesenchymal precartilage forming the framework of the cranium and the face, notably, the base of the skull, frontonasal process and parts of the primitive maxillary and mandibular processes. Around 13 dpc, detected in the brain lateral ventricles and the roof of the fourth ventricle. At 15 dpc, scattered groups of positive cells are observed in the liver, around the venous sinuses. Weakly expressed in the brain and spinal cord white matter. Prominent membrane expression in the choroid plexus and meninges. At 15-18 dpc, transiently expressed in the layers of ectodermal cells covering the embryo and in immature cells of the lung buds. From 16 dpc to postnatal day 2, no change in the basic pattern of expression (at protein level). Palmitoylation and myristoylation target the protein to the lipid rafts. molecular_function nucleus cytoplasm cytosol plasma membrane biological_process postsynaptic density membrane cell junction neuron projection membrane raft synapse postsynaptic membrane uc288xtv.1 uc288xtv.2 
ENSMUST00000226445.3 Gm55330 ENSMUST00000226445.3 Gm55330 (from geneSymbol) AK004571 ENSMUST00000226445.1 ENSMUST00000226445.2 uc288svm.1 uc288svm.2 uc288svm.3 uc288svm.1 uc288svm.2 uc288svm.3 
ENSMUST00000226452.2 Gm49236 ENSMUST00000226452.2 Gm49236 (from geneSymbol) ENSMUST00000226452.1 uc288wou.1 uc288wou.2 uc288wou.1 uc288wou.2 
ENSMUST00000226455.2 Ccdc148 ENSMUST00000226455.2 coiled-coil domain containing 148, transcript variant 4 (from RefSeq NM_001372501.1) A0A2I3BPW3 A0A2I3BPW3_MOUSE Ccdc148 ENSMUST00000226455.1 NM_001372501 uc289wgg.1 uc289wgg.2 uc289wgg.1 uc289wgg.2 
ENSMUST00000226457.2 Vmn1r38 ENSMUST00000226457.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2E1) ENSMUST00000226457.1 Q8R2E1 Q8R2E1_MOUSE V1rc13 Vmn1r38 uc291fdu.1 uc291fdu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291fdu.1 uc291fdu.2 
ENSMUST00000226459.2 Dnajc15 ENSMUST00000226459.2 DnaJ heat shock protein family (Hsp40) member C15 (from RefSeq NM_025384.3) DJC15_MOUSE Dnajd1 ENSMUST00000226459.1 NM_025384 Q78YY6 uc007usc.1 uc007usc.2 uc007usc.3 Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9 (By similarity). Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP. Interacts with the TIM23 complex. Directly interacts with PAM16/MAGMAS; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity (By similarity). Associates with complex I of the mitochondrial electron transfer chain; this interaction may interfere with the formation of supercomplexes that facilitate the transfer of electrons between complexes. Mitochondrion inner membrane ; Single-pass membrane protein Expressed at high levels in liver, heart, at moderate levels in kidney and, at very low levels, in lung (at protein level). High expression levels in testis. Highly expressed in CD8+ T- cells, but barely detectable in CD4+ T-cells (at protein level). Almost undetectable in B-cells. No visible phenotype. Mutant animals are viable. Both male and female are fertile and do not exhibit any obvious malformations or behavioral abnormalities. CD8+ T-cell mitochondria are hyperpolarized, compared to their wild-type counterparts. In fasted mutant animals, livers do not exhibit any signs of steatosis, but accumulate glycogen, possibly due to a sustained mitochondrial oxidation that leads to rapid metabolism of lipids, hence minimizing their accumulation in the liver and favoring glycogenesis. During fasting, loss of white fat is also more prominent than in wild type animals. presequence translocase-associated import motor ATPase activator activity protein binding mitochondrion mitochondrial inner membrane cellular response to starvation protein transport membrane integral component of membrane regulation of lipid metabolic process protein import into mitochondrial matrix negative regulation of protein complex assembly positive regulation of ATPase activity negative regulation of mitochondrial electron transport, NADH to ubiquinone uc007usc.1 uc007usc.2 uc007usc.3 
ENSMUST00000226484.2 Mucl1 ENSMUST00000226484.2 mucin-like 1, transcript variant 1, non-coding (from RefSeq NR_126081.1) A0A2I3BRB8 A0A2I3BRB8_MOUSE ENSMUST00000226484.1 Mucl1 NR_126081 uc056zar.1 uc056zar.2 uc056zar.3 molecular_function cellular_component biological_process uc056zar.1 uc056zar.2 uc056zar.3 
ENSMUST00000226485.2 Gm55359 ENSMUST00000226485.2 Gm55359 (from geneSymbol) A0A2I3BQS8 A0A2I3BQS8_MOUSE ENSMUST00000226485.1 Gm55359 uc288zua.1 uc288zua.2 mitochondrion mitochondrial matrix mitochondrial large ribosomal subunit positive regulation of mitochondrial translation uc288zua.1 uc288zua.2 
ENSMUST00000226491.2 Gm48992 ENSMUST00000226491.2 Gm48992 (from geneSymbol) ENSMUST00000226491.1 uc288wke.1 uc288wke.2 uc288wke.1 uc288wke.2 
ENSMUST00000226498.2 Gm49002 ENSMUST00000226498.2 Gm49002 (from geneSymbol) AK138334 ENSMUST00000226498.1 uc288vuo.1 uc288vuo.2 uc288vuo.1 uc288vuo.2 
ENSMUST00000226516.2 Vmn1r73 ENSMUST00000226516.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R293) E9Q311 ENSMUST00000226516.1 Q8R293 Q8R293_MOUSE V1rg2 Vmn1r73 Vmn1r80 uc291llv.1 uc291llv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291llv.1 uc291llv.2 
ENSMUST00000226519.2 Pck2 ENSMUST00000226519.2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) (from RefSeq NM_028994.3) ENSMUST00000226519.1 NM_028994 PCKGM_MOUSE Q8BH04 Q8BMM9 Q91Z10 uc288umc.1 uc288umc.2 Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity). Can play an active role in glyceroneogenesis and gluconeogenesis (PubMed:33147485). Reaction=GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate; Xref=Rhea:RHEA:10388, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526, ChEBI:CHEBI:37565, ChEBI:CHEBI:58189, ChEBI:CHEBI:58702; EC=4.1.1.32; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10389; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mn(2+) ion per subunit. ; Carbohydrate biosynthesis; gluconeogenesis. Monomer. Mitochondrion Homozygous deficient mice are viable with no overt phenotype (PubMed:33147485, PubMed:36845668). However fasting plasma glucose are elevated from regular chow-fed deficient mice, indicative of defective glucose homeostasis (PubMed:33147485). Deficient mice present abnormal nerve conduction studies and peripheral nerve pathology (PubMed:36845668). In eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one. Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. Sequence=BAC26991.1; Type=Erroneous initiation; Evidence=; nucleotide binding phosphoenolpyruvate carboxykinase activity phosphoenolpyruvate carboxykinase (GTP) activity GTP binding mitochondrion cytosol pyruvate metabolic process gluconeogenesis oxaloacetate metabolic process NADH oxidation lyase activity carboxy-lyase activity purine nucleotide binding propionate catabolic process manganese ion binding positive regulation of insulin secretion cellular response to insulin stimulus response to lipid response to starvation glycerol biosynthetic process from pyruvate metal ion binding hepatocyte differentiation cellular response to glucose stimulus cellular response to dexamethasone stimulus uc288umc.1 uc288umc.2 
ENSMUST00000226531.2 Gm48924 ENSMUST00000226531.2 Gm48924 (from geneSymbol) ENSMUST00000226531.1 uc288tbw.1 uc288tbw.2 uc288tbw.1 uc288tbw.2 
ENSMUST00000226532.2 ENSMUSG00000121706 ENSMUST00000226532.2 ENSMUSG00000121706 (from geneSymbol) ENSMUST00000226532.1 uc288sef.1 uc288sef.2 uc288sef.1 uc288sef.2 
ENSMUST00000226540.2 Gm49743 ENSMUST00000226540.2 Gm49743 (from geneSymbol) ENSMUST00000226540.1 uc288sgw.1 uc288sgw.2 uc288sgw.1 uc288sgw.2 
ENSMUST00000226550.2 Gm49092 ENSMUST00000226550.2 Gm49092 (from geneSymbol) ENSMUST00000226550.1 uc289hsv.1 uc289hsv.2 uc289hsv.1 uc289hsv.2 
ENSMUST00000226557.2 Gm49171 ENSMUST00000226557.2 Gm49171 (from geneSymbol) AK044155 ENSMUST00000226557.1 uc288vqy.1 uc288vqy.2 uc288vqy.1 uc288vqy.2 
ENSMUST00000226560.2 Gm55960 ENSMUST00000226560.2 Gm55960 (from geneSymbol) A0A2I3BR05 A0A2I3BR05_MOUSE AY454345 ENSMUST00000226560.1 Gm55960 uc290pme.1 uc290pme.2 uc290pme.1 uc290pme.2 
ENSMUST00000226569.2 4933425B07Rik ENSMUST00000226569.2 RIKEN cDNA 4933425B07 gene (from RefSeq NR_046460.1) ENSMUST00000226569.1 NR_046460 uc029sis.1 uc029sis.2 uc029sis.1 uc029sis.2 
ENSMUST00000226570.2 Gm49160 ENSMUST00000226570.2 Gm49160 (from geneSymbol) ENSMUST00000226570.1 uc288xdp.1 uc288xdp.2 uc288xdp.1 uc288xdp.2 
ENSMUST00000226577.2 Vmn1r50 ENSMUST00000226577.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (from UniProt Q9EP51) ENSMUST00000226577.1 Q8VIC3 Q9EP51 V1R50_MOUSE V1ra5 V1rb1 uc291gzn.1 uc291gzn.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Cell membrane ; Multi-pass membrane protein Expressed in a subset of sensory neurons located in the apical layer of the vomeronasal organ. Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291gzn.1 uc291gzn.2 
ENSMUST00000226586.2 Tbc1d23 ENSMUST00000226586.2 TBC1 domain family, member 23, transcript variant 3 (from RefSeq NM_001358434.1) A0A2I3BRD1 A0A2I3BRD1_MOUSE ENSMUST00000226586.1 NM_001358434 Tbc1d23 uc289fdb.1 uc289fdb.2 Golgi apparatus, trans-Golgi network cytosol retrograde transport, endosome to Golgi uc289fdb.1 uc289fdb.2 
ENSMUST00000226593.2 Cblb ENSMUST00000226593.2 E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (PubMed:29237719). (from UniProt Q3TTA7) AK171350 CBLB_MOUSE E9QMY2 ENSMUST00000226593.1 Q3TTA7 uc007zlf.1 uc007zlf.2 uc007zlf.3 uc007zlf.4 E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (PubMed:29237719). Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with SH3 domain-containing proteins LCK, CRK and SORBS1. Interacts with LCP2 and ZAP70. Interacts with CBL. Interacts with SH3 domain-containing proteins VAV1, FYN, FGR, PLCG1, GRB2, CRKL, PIK3R1 and SH3KBP1/CIN85. Identified in heterotrimeric complexes with SH3KBP1/CIN85, CD2AP and ARHGEF7, where one CBLB peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is required for the binding of poly-ubiquitin, but not for the binding of mono-ubiquitin. Interacts with EGFR (phosphorylated). Interacts with IFT20 (By similarity). Q3TTA7; P13379: Cd5; NbExp=4; IntAct=EBI-3649276, EBI-12600513; Q3TTA7; P22366: Myd88; NbExp=2; IntAct=EBI-3649276, EBI-525108; Q3TTA7; Q80UF7: Ticam1; NbExp=2; IntAct=EBI-3649276, EBI-3649271; Cytoplasm Note=In adipocytes, translocates to the plasma membrane upon insulin stimulation. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TTA7-1; Sequence=Displayed; Name=2; IsoId=Q3TTA7-2; Sequence=VSP_017222; By serum starvation. The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. The UBA domain interacts with poly-ubiquitinated proteins. Phosphorylated on tyrosine and serine residues upon TCR or BCR activation. Phosphorylated on Tyr-664 and Tyr-708 in adipocytes following insulin stimulation. Auto-ubiquitinated upon EGF-mediated cell activation or upon T- cell costimulation by CD28; which promotes proteasomal degradation. Mice are fertile and grossly normal. However, they show a high sensitivity to autoimmune diseases and may develop a spontaneous generalized autoimmune disorder characterized by auto- antibody production, infiltration of activated T- and B-lymphocytes into various organs and parenchymal damage. This protein has one functional calcium-binding site. phosphotyrosine binding positive regulation of T cell anergy ubiquitin-protein transferase activity calcium ion binding protein binding nucleoplasm cytoplasm cytosol plasma membrane immune response signal transduction cell surface receptor signaling pathway negative regulation of epidermal growth factor-activated receptor activity protein ubiquitination transferase activity SH3 domain binding peptidyl-amino acid modification protein kinase binding regulation of signaling regulation of cell adhesion receptor tyrosine kinase binding positive regulation of protein ubiquitination intracellular signal transduction T cell activation regulation of GTPase activity regulation of protein binding membrane raft positive regulation of protein catabolic process negative regulation of alpha-beta T cell proliferation metal ion binding T cell receptor signaling pathway regulation of T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway ubiquitin protein ligase activity regulation of platelet-derived growth factor receptor-alpha signaling pathway uc007zlf.1 uc007zlf.2 uc007zlf.3 uc007zlf.4 
ENSMUST00000226602.3 Gm49225 ENSMUST00000226602.3 Gm49225 (from geneSymbol) ENSMUST00000226602.1 ENSMUST00000226602.2 uc288web.1 uc288web.2 uc288web.3 uc288web.1 uc288web.2 uc288web.3 
ENSMUST00000226604.2 Vmn1r86 ENSMUST00000226604.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N213) ENSMUST00000226604.1 L7N213 L7N213_MOUSE Vmn1r86 uc291lrx.1 uc291lrx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lrx.1 uc291lrx.2 
ENSMUST00000226613.2 Gprin2 ENSMUST00000226613.2 G protein regulated inducer of neurite outgrowth 2 (from RefSeq NM_183209.3) A0A2I3BRN2 A0A2I3BRN2_MOUSE ENSMUST00000226613.1 Gprin2 NM_183209 uc011zit.1 uc011zit.2 uc011zit.3 May be involved in neurite outgrowth. molecular_function cellular_component biological_process uc011zit.1 uc011zit.2 uc011zit.3 
ENSMUST00000226645.2 4930404O17Rik ENSMUST00000226645.2 4930404O17Rik (from geneSymbol) AK015089 ENSMUST00000226645.1 uc288wrh.1 uc288wrh.2 uc288wrh.1 uc288wrh.2 
ENSMUST00000226647.2 Gm49204 ENSMUST00000226647.2 Gm49204 (from geneSymbol) ENSMUST00000226647.1 LF199912 uc288tir.1 uc288tir.2 uc288tir.1 uc288tir.2 
ENSMUST00000226657.2 Gm49182 ENSMUST00000226657.2 Gm49182 (from geneSymbol) ENSMUST00000226657.1 uc288xee.1 uc288xee.2 uc288xee.1 uc288xee.2 
ENSMUST00000226667.3 Ang5 ENSMUST00000226667.3 angiogenin, ribonuclease A family, member 5 (from RefSeq NM_007448.3) Ang5 ENSMUST00000226667.1 ENSMUST00000226667.2 NM_007448 Q5GAN1 Q5GAN1_MOUSE uc288stn.1 uc288stn.2 uc288stn.3 Cytoplasmic vesicle, secretory vesicle lumen Nucleus, nucleolus Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity ribonuclease activity cellular_component hydrolase activity nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis uc288stn.1 uc288stn.2 uc288stn.3 
ENSMUST00000226670.3 5430440P10Rik ENSMUST00000226670.3 RIKEN cDNA 5430440P10 gene (from RefSeq NR_045859.1) ENSMUST00000226670.1 ENSMUST00000226670.2 NR_045859 uc029smu.1 uc029smu.2 uc029smu.3 uc029smu.1 uc029smu.2 uc029smu.3 
ENSMUST00000226674.2 Gm49260 ENSMUST00000226674.2 Gm49260 (from geneSymbol) ENSMUST00000226674.1 uc288wpp.1 uc288wpp.2 uc288wpp.1 uc288wpp.2 
ENSMUST00000226696.2 Gm49164 ENSMUST00000226696.2 Gm49164 (from geneSymbol) AK135997 ENSMUST00000226696.1 uc288vqq.1 uc288vqq.2 uc288vqq.1 uc288vqq.2 
ENSMUST00000226700.2 Gm48933 ENSMUST00000226700.2 Gm48933 (from geneSymbol) ENSMUST00000226700.1 uc288tcb.1 uc288tcb.2 uc288tcb.1 uc288tcb.2 
ENSMUST00000226701.2 Vmn1r83 ENSMUST00000226701.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R287) ENSMUST00000226701.1 Q8R287 Q8R287_MOUSE V1rg8 Vmn1r83 uc009fdy.1 uc009fdy.2 uc009fdy.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009fdy.1 uc009fdy.2 uc009fdy.3 
ENSMUST00000226704.2 9630013A20Rik ENSMUST00000226704.2 9630013A20Rik (from geneSymbol) AK161845 ENSMUST00000226704.1 uc007uts.1 uc007uts.2 uc007uts.3 uc007uts.4 uc007uts.1 uc007uts.2 uc007uts.3 uc007uts.4 
ENSMUST00000226719.2 Gm49280 ENSMUST00000226719.2 Gm49280 (from geneSymbol) ENSMUST00000226719.1 uc288xip.1 uc288xip.2 uc288xip.1 uc288xip.2 
ENSMUST00000226731.2 Gm49159 ENSMUST00000226731.2 Gm49159 (from geneSymbol) ENSMUST00000226731.1 uc288vzg.1 uc288vzg.2 uc288vzg.1 uc288vzg.2 
ENSMUST00000226738.2 Gm48946 ENSMUST00000226738.2 Gm48946 (from geneSymbol) ENSMUST00000226738.1 uc288ygi.1 uc288ygi.2 uc288ygi.1 uc288ygi.2 
ENSMUST00000226752.2 Gm49179 ENSMUST00000226752.2 Gm49179 (from geneSymbol) ENSMUST00000226752.1 LF200141 uc288wmg.1 uc288wmg.2 uc288wmg.1 uc288wmg.2 
ENSMUST00000226755.2 Gm48972 ENSMUST00000226755.2 Gm48972 (from geneSymbol) AK076329 ENSMUST00000226755.1 uc288wiz.1 uc288wiz.2 uc288wiz.1 uc288wiz.2 
ENSMUST00000226763.2 Gm45924 ENSMUST00000226763.2 predicted gene, 45924 (from RefSeq NR_131206.1) ENSMUST00000226763.1 NR_131206 uc056yyn.1 uc056yyn.2 uc056yyn.1 uc056yyn.2 
ENSMUST00000226773.3 1700010G06Rik ENSMUST00000226773.3 1700010G06Rik (from geneSymbol) AK005824 ENSMUST00000226773.1 ENSMUST00000226773.2 uc288yjs.1 uc288yjs.2 uc288yjs.3 uc288yjs.1 uc288yjs.2 uc288yjs.3 
ENSMUST00000226792.3 Gm49791 ENSMUST00000226792.3 Gm49791 (from geneSymbol) ENSMUST00000226792.1 ENSMUST00000226792.2 uc288scl.1 uc288scl.2 uc288scl.3 uc288scl.1 uc288scl.2 uc288scl.3 
ENSMUST00000226795.2 Gm49197 ENSMUST00000226795.2 Gm49197 (from geneSymbol) ENSMUST00000226795.1 uc288vzs.1 uc288vzs.2 uc288vzs.1 uc288vzs.2 
ENSMUST00000226796.2 Ear-ps9 ENSMUST00000226796.2 Ear-ps9 (from geneSymbol) ENSMUST00000226796.1 uc288sth.1 uc288sth.2 uc288sth.1 uc288sth.2 
ENSMUST00000226810.2 Rspo2 ENSMUST00000226810.2 R-spondin 2, transcript variant 2 (from RefSeq NM_001357956.1) ENSMUST00000226810.1 NM_001357956 Q7TPX3 Q8BFU0 RSPO2_MOUSE uc007vph.1 uc007vph.2 uc007vph.3 Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors (PubMed:21693646). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (By similarity). Interacts with WNT1 (PubMed:16543246). Binds heparin (PubMed:16543246). Interacts with LGR4, LGR5 and LGR6 (PubMed:21693646). Secreted Detected from day 9.5 in various neural and mesodermal derivatives, mainly along diencephalon. Strongly expressed in limb buds, particularly in the morphogenetically active region such as the apical ectodermal ridge (AER). The FU repeat is required for activation and stabilization of beta-catenin. Belongs to the R-spondin family. Sequence=BC052844; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; osteoblast differentiation receptor binding extracellular region multicellular organism development heparin binding cell surface Wnt signaling pathway positive regulation of Wnt signaling pathway bone mineralization embryonic forelimb morphogenesis embryonic hindlimb morphogenesis negative regulation of odontogenesis of dentin-containing tooth response to stimulus limb development lung growth epithelial tube branching involved in lung morphogenesis trachea cartilage morphogenesis dopaminergic neuron differentiation positive regulation of canonical Wnt signaling pathway uc007vph.1 uc007vph.2 uc007vph.3 
ENSMUST00000226812.2 Gm35019 ENSMUST00000226812.2 Gm35019 (from geneSymbol) AK144463 ENSMUST00000226812.1 uc288xrr.1 uc288xrr.2 uc288xrr.1 uc288xrr.2 
ENSMUST00000226822.3 4930433E05Rik ENSMUST00000226822.3 4930433E05Rik (from geneSymbol) AK019593 ENSMUST00000226822.1 ENSMUST00000226822.2 uc007uuk.1 uc007uuk.2 uc007uuk.3 uc007uuk.1 uc007uuk.2 uc007uuk.3 
ENSMUST00000226827.2 Eny2 ENSMUST00000226827.2 ENY2 transcription and export complex 2 subunit, transcript variant 2 (from RefSeq NM_001418909.1) A0A2I3BRK6 A0A2I3BRK6_MOUSE ENSMUST00000226827.1 ENY2 Eny2 NM_001418909 uc007vpu.1 uc007vpu.2 uc007vpu.3 Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor- mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator- HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B. Nucleus, nucleoplasm Belongs to the ENY2 family. SAGA complex transcription coactivator activity nucleus nuclear pore nucleoplasm chromatin organization transcription elongation from RNA polymerase II promoter mRNA export from nucleus protein transport histone deubiquitination ligand-dependent nuclear receptor transcription coactivator activity positive regulation of transcription, DNA-templated mRNA transport transcription export complex 2 DUBm complex uc007vpu.1 uc007vpu.2 uc007vpu.3 
ENSMUST00000226829.2 Vmn1r36 ENSMUST00000226829.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2E3) ENSMUST00000226829.1 Q8R2E3 Q8R2E3_MOUSE V1rc11 Vmn1r36 uc291fdk.1 uc291fdk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291fdk.1 uc291fdk.2 
ENSMUST00000226844.2 ENSMUSG00000121689 ENSMUST00000226844.2 ENSMUSG00000121689 (from geneSymbol) AK155799 ENSMUST00000226844.1 uc288vou.1 uc288vou.2 uc288vou.1 uc288vou.2 
ENSMUST00000226853.2 Gm49015 ENSMUST00000226853.2 Gm49015 (from geneSymbol) ENSMUST00000226853.1 uc288vwa.1 uc288vwa.2 uc288vwa.1 uc288vwa.2 
ENSMUST00000226862.4 Gm26670 ENSMUST00000226862.4 Gm26670 (from geneSymbol) ENSMUST00000226862.1 ENSMUST00000226862.2 ENSMUST00000226862.3 uc287pak.1 uc287pak.2 uc287pak.3 uc287pak.4 uc287pak.1 uc287pak.2 uc287pak.3 uc287pak.4 
ENSMUST00000226863.3 Gm34678 ENSMUST00000226863.3 Gm34678 (from geneSymbol) ENSMUST00000226863.1 ENSMUST00000226863.2 uc288xzw.1 uc288xzw.2 uc288xzw.3 uc288xzw.1 uc288xzw.2 uc288xzw.3 
ENSMUST00000226866.2 Vmn1r12 ENSMUST00000226866.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt G5E8G1) ENSMUST00000226866.1 G5E8G1 G5E8G1_MOUSE Vmn1r12 uc291etq.1 uc291etq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291etq.1 uc291etq.2 
ENSMUST00000226873.2 Styx ENSMUST00000226873.2 serine/threonine/tyrosine interaction protein (from RefSeq NM_019637.3) ENSMUST00000226873.1 NM_019637 Q3TMA3 Q60969 Q60970 Q9DCF8 STYX_MOUSE Styx uc007tgo.1 uc007tgo.2 uc007tgo.3 Catalytically inactive phosphatase (PubMed:7592916). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (By similarity). Plays a role in spermatogenesis (PubMed:11842224). Interacts with MAPK1; independently of MAPK1 phosphorylation status (By similarity). Interacts with CARHSP1/Crhsp-24 (PubMed:11842224). Interacts (via FQQ motif) with FBXW7 (via F-box domain); the interaction is direct and prevents FBXW7 interaction with SKP1, a component of the SCF(FBXW7) complex (By similarity). Nucleus Cytoplasm, cytosol Note=Predominantly localizes to the nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q60969-1; Sequence=Displayed; Name=2; IsoId=Q60969-2; Sequence=VSP_005174; Widely expressed with highest levels in muscle, testis and brain (PubMed:7592916). In testis, expression starts 13-14 days after birth and is limited to the seminiferous tubule and to round and elongating spermatids (PubMed:11842224). Expression is low in condensing spermatids and pachytene spermatocytes, and absent in spermatogonia, spermatozoa and somatic Sertoli cells (PubMed:11842224). Males are infertile due to a disrupted spermatid development, resulting in a >1000-fold decrease in spermatozoa production. Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. Contains a Gly residue instead of a conserved Cys residue at position 120 in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and may protect them from phosphatases. pseudophosphatase activity protein binding nucleus nucleoplasm cytoplasm cytosol protein dephosphorylation spermatogenesis protein tyrosine/serine/threonine phosphatase activity dephosphorylation phosphatase activity negative regulation of protein binding negative regulation of catalytic activity MAPK export from nucleus regulation of ERK1 and ERK2 cascade F-box domain binding uc007tgo.1 uc007tgo.2 uc007tgo.3 
ENSMUST00000226882.2 ENSMUSG00000121710 ENSMUST00000226882.2 ENSMUSG00000121710 (from geneSymbol) ENSMUST00000226882.1 uc288vzw.1 uc288vzw.2 uc288vzw.1 uc288vzw.2 
ENSMUST00000226885.2 Smim40-ps ENSMUST00000226885.2 Smim40-ps (from geneSymbol) A0A2I3BR68 A0A2I3BR68_MOUSE ENSMUST00000226885.1 Smim40-ps uc289jxi.1 uc289jxi.2 membrane integral component of membrane uc289jxi.1 uc289jxi.2 
ENSMUST00000226888.2 Gm49231 ENSMUST00000226888.2 Gm49231 (from geneSymbol) ENSMUST00000226888.1 uc288wrk.1 uc288wrk.2 uc288wrk.1 uc288wrk.2 
ENSMUST00000226894.2 Gm48948 ENSMUST00000226894.2 Gm48948 (from geneSymbol) AK084441 ENSMUST00000226894.1 uc288tjv.1 uc288tjv.2 uc288tjv.1 uc288tjv.2 
ENSMUST00000226897.2 Gm49026 ENSMUST00000226897.2 Gm49026 (from geneSymbol) AK086867 ENSMUST00000226897.1 uc288wdq.1 uc288wdq.2 uc288wdq.1 uc288wdq.2 
ENSMUST00000226900.2 Gm8267 ENSMUST00000226900.2 Gm8267 (from geneSymbol) E9Q207 E9Q207_MOUSE ENSMUST00000226900.1 Gm8267 uc288swg.1 uc288swg.2 molecular_function cellular_component biological_process membrane integral component of membrane uc288swg.1 uc288swg.2 
ENSMUST00000226909.2 Vmn1r198 ENSMUST00000226909.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R263) ENSMUST00000226909.1 Q8R263 Q8R263_MOUSE V1ri3 Vmn1r198 uc288lia.1 uc288lia.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lia.1 uc288lia.2 
ENSMUST00000226912.2 4930557F08Rik ENSMUST00000226912.2 4930557F08Rik (from geneSymbol) AK016160 ENSMUST00000226912.1 uc288xcl.1 uc288xcl.2 uc288xcl.1 uc288xcl.2 
ENSMUST00000226916.2 Gm49152 ENSMUST00000226916.2 Gm49152 (from geneSymbol) AK053585 ENSMUST00000226916.1 uc288tif.1 uc288tif.2 uc288tif.1 uc288tif.2 
ENSMUST00000226921.2 Vmn1r54 ENSMUST00000226921.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (from UniProt Q9EPB8) ENSMUST00000226921.1 Q9EPB8 V1R54_MOUSE V1ra9 uc291hal.1 uc291hal.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Cell membrane ; Multi-pass membrane protein Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291hal.1 uc291hal.2 
ENSMUST00000226927.2 4933402J15Rik ENSMUST00000226927.2 RIKEN cDNA 4933402J15 gene (from RefSeq NR_046059.1) ENSMUST00000226927.1 NR_046059 uc029slw.1 uc029slw.2 uc029slw.1 uc029slw.2 
ENSMUST00000226930.2 Gm10370 ENSMUST00000226930.2 Gm10370 (from geneSymbol) AK157412 ENSMUST00000226930.1 uc288ycj.1 uc288ycj.2 uc288ycj.1 uc288ycj.2 
ENSMUST00000226933.2 Gm49030 ENSMUST00000226933.2 Gm49030 (from geneSymbol) ENSMUST00000226933.1 uc288shq.1 uc288shq.2 uc288shq.1 uc288shq.2 
ENSMUST00000226943.2 Gm49293 ENSMUST00000226943.2 Gm49293 (from geneSymbol) AK089323 ENSMUST00000226943.1 uc288vos.1 uc288vos.2 uc288vos.1 uc288vos.2 
ENSMUST00000226947.2 Vmn1r76 ENSMUST00000226947.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BQH4) A0A2I3BQH4 A0A2I3BQH4_MOUSE ENSMUST00000226947.1 Vmn1r76 uc291lmm.1 uc291lmm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lmm.1 uc291lmm.2 
ENSMUST00000226948.2 Gm19303 ENSMUST00000226948.2 predicted gene, 19303 (from RefSeq NR_045092.1) ENSMUST00000226948.1 NR_045092 uc029spa.1 uc029spa.2 uc029spa.1 uc029spa.2 
ENSMUST00000226949.2 D330046F09Rik ENSMUST00000226949.2 RIKEN cDNA D330046F09 gene (from RefSeq NR_131909.1) ENSMUST00000226949.1 NR_131909 uc057bew.1 uc057bew.2 uc057bew.3 uc057bew.1 uc057bew.2 uc057bew.3 
ENSMUST00000226962.3 Gm49042 ENSMUST00000226962.3 Gm49042 (from geneSymbol) ENSMUST00000226962.1 ENSMUST00000226962.2 uc288vww.1 uc288vww.2 uc288vww.3 uc288vww.1 uc288vww.2 uc288vww.3 
ENSMUST00000226968.2 Vmn1r11 ENSMUST00000226968.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q3SXA2) ENSMUST00000226968.1 Q3SXA2 Q3SXA2_MOUSE V1rc3 Vmn1r11 uc291eto.1 uc291eto.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291eto.1 uc291eto.2 
ENSMUST00000226969.2 Gm49263 ENSMUST00000226969.2 Gm49263 (from geneSymbol) ENSMUST00000226969.1 uc288xps.1 uc288xps.2 uc288xps.1 uc288xps.2 
ENSMUST00000226970.3 Gm49086 ENSMUST00000226970.3 Gm49086 (from geneSymbol) AK046725 ENSMUST00000226970.1 ENSMUST00000226970.2 uc288tsm.1 uc288tsm.2 uc288tsm.3 uc288tsm.1 uc288tsm.2 uc288tsm.3 
ENSMUST00000226974.2 Vmn1r37 ENSMUST00000226974.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2E4) ENSMUST00000226974.1 Q8R2E4 Q8R2E4_MOUSE V1rc10 Vmn1r35 Vmn1r37 uc291fdm.1 uc291fdm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291fdm.1 uc291fdm.2 
ENSMUST00000226995.2 Gm49270 ENSMUST00000226995.2 Gm49270 (from geneSymbol) ENSMUST00000226995.1 LF199843 uc288sdb.1 uc288sdb.2 uc288sdb.1 uc288sdb.2 
ENSMUST00000226999.2 Vmn1r34 ENSMUST00000226999.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt G3XA52) ENSMUST00000226999.1 G3XA52 G3XA52_MOUSE Vmn1r34 uc291fdc.1 uc291fdc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291fdc.1 uc291fdc.2 
ENSMUST00000227000.2 Gm34562 ENSMUST00000227000.2 Gm34562 (from geneSymbol) ENSMUST00000227000.1 uc288xzp.1 uc288xzp.2 uc288xzp.1 uc288xzp.2 
ENSMUST00000227010.2 Vmn1r72 ENSMUST00000227010.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8K3N7) ENSMUST00000227010.1 Q8K3N7 Q8K3N7_MOUSE V1rg1 Vmn1r72 uc291lls.1 uc291lls.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lls.1 uc291lls.2 
ENSMUST00000227014.2 Vmn1r32 ENSMUST00000227014.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2D9) AK029205 ENSMUST00000227014.1 Q8R2D9 Q8R2D9_MOUSE V1rc15 Vmn1r32 uc033ise.1 uc033ise.2 uc033ise.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc033ise.1 uc033ise.2 uc033ise.3 
ENSMUST00000227017.2 Vmn1r197 ENSMUST00000227017.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R265) ENSMUST00000227017.1 Q8R265 Q8R265_MOUSE V1rh21 Vmn1r197 uc288lhx.1 uc288lhx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lhx.1 uc288lhx.2 
ENSMUST00000227028.3 Gm49364 ENSMUST00000227028.3 Gm49364 (from geneSymbol) AK133263 ENSMUST00000227028.1 ENSMUST00000227028.2 uc288swz.1 uc288swz.2 uc288swz.3 uc288swz.1 uc288swz.2 uc288swz.3 
ENSMUST00000227033.2 Gm48952 ENSMUST00000227033.2 Gm48952 (from geneSymbol) ENSMUST00000227033.1 uc288ywy.1 uc288ywy.2 uc288ywy.1 uc288ywy.2 
ENSMUST00000227034.2 Gm49308 ENSMUST00000227034.2 Gm49308 (from geneSymbol) ENSMUST00000227034.1 LF199847 uc288sed.1 uc288sed.2 uc288sed.1 uc288sed.2 
ENSMUST00000227036.2 Gm49226 ENSMUST00000227036.2 Gm49226 (from geneSymbol) ENSMUST00000227036.1 uc289ftf.1 uc289ftf.2 uc289ftf.1 uc289ftf.2 
ENSMUST00000227040.2 Gm49271 ENSMUST00000227040.2 Gm49271 (from geneSymbol) ENSMUST00000227040.1 uc288xwu.1 uc288xwu.2 uc288xwu.1 uc288xwu.2 
ENSMUST00000227050.2 Vmn1r218 ENSMUST00000227050.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R261) ENSMUST00000227050.1 Q8R261 Q8R261_MOUSE V1ri5 Vmn1r218 uc288lks.1 uc288lks.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lks.1 uc288lks.2 
ENSMUST00000227051.2 Gm41168 ENSMUST00000227051.2 Gm41168 (from geneSymbol) ENSMUST00000227051.1 uc288uzt.1 uc288uzt.2 uc288uzt.1 uc288uzt.2 
ENSMUST00000227052.2 Gm49342 ENSMUST00000227052.2 Reaction=2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + guanine; Xref=Rhea:RHEA:27738, ChEBI:CHEBI:16235, ChEBI:CHEBI:17172, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.1; Evidence=; (from UniProt A0A2I3BQH2) A0A2I3BQH2 A0A2I3BQH2_MOUSE ENSMUST00000227052.1 Gm49342 M84563 uc288tnz.1 uc288tnz.2 Reaction=2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + guanine; Xref=Rhea:RHEA:27738, ChEBI:CHEBI:16235, ChEBI:CHEBI:17172, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.1; Evidence=; Reaction=2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + hypoxanthine; Xref=Rhea:RHEA:27750, ChEBI:CHEBI:17368, ChEBI:CHEBI:28997, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.1; Evidence=; Reaction=guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine; Xref=Rhea:RHEA:13233, ChEBI:CHEBI:16235, ChEBI:CHEBI:16750, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.1; Evidence=; Reaction=inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine; Xref=Rhea:RHEA:27646, ChEBI:CHEBI:17368, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.1; Evidence=; Purine metabolism; purine nucleoside salvage. Homotrimer. Belongs to the PNP/MTAP phosphorylase family. catalytic activity purine-nucleoside phosphorylase activity nucleobase-containing compound metabolic process nucleoside metabolic process transferase activity, transferring pentosyl groups uc288tnz.1 uc288tnz.2 
ENSMUST00000227061.2 Rabggta ENSMUST00000227061.2 Rab geranylgeranyl transferase, a subunit, transcript variant 2 (from RefSeq NM_001360388.1) ENSMUST00000227061.1 NM_001360388 PGTA_MOUSE Q9JHK4 Q9JLX2 uc007uak.1 uc007uak.2 uc007uak.3 Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537, ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533, ChEBI:CHEBI:86021; EC=2.5.1.60; The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM. Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp. Interacts with non- phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JHK4-1; Sequence=Displayed; Name=2; IsoId=Q9JHK4-2; Sequence=VSP_009113, VSP_009114; Note=Defects in Rabggta are the cause of the gunmetal (gm) phenotype. Mice homozygous for gm have prolonged bleeding, thrombocytopenia and reduced platelet alpha- and delta-granule contents. Belongs to the protein prenyltransferase subunit alpha family. prenyltransferase activity Rab geranylgeranyltransferase activity nucleoplasm cytoplasm Rab-protein geranylgeranyltransferase complex zinc ion binding protein prenyltransferase activity transferase activity Rab GTPase binding protein prenylation protein geranylgeranylation protein heterodimerization activity macromolecular complex assembly uc007uak.1 uc007uak.2 uc007uak.3 
ENSMUST00000227063.4 Bc1 ENSMUST00000227063.4 brain cytoplasmic RNA 1 (from RefSeq NR_038088.1) ENSMUST00000227063.1 ENSMUST00000227063.2 ENSMUST00000227063.3 NR_038088 uc057lwc.1 uc057lwc.2 uc057lwc.3 uc057lwc.4 uc057lwc.5 uc057lwc.1 uc057lwc.2 uc057lwc.3 uc057lwc.4 uc057lwc.5 
ENSMUST00000227068.2 Gm49265 ENSMUST00000227068.2 Gm49265 (from geneSymbol) AK135355 ENSMUST00000227068.1 uc288xgy.1 uc288xgy.2 uc288xgy.1 uc288xgy.2 
ENSMUST00000227082.2 Lincmd1 ENSMUST00000227082.2 long intergenic non-protein coding RNA of muscle differentiation 1 (from RefSeq NR_131249.1) ENSMUST00000227082.1 NR_131249 uc029qne.1 uc029qne.2 uc029qne.1 uc029qne.2 
ENSMUST00000227092.2 Gm48911 ENSMUST00000227092.2 Gm48911 (from geneSymbol) ENSMUST00000227092.1 uc288tbi.1 uc288tbi.2 uc288tbi.1 uc288tbi.2 
ENSMUST00000227096.2 Nt5dc2 ENSMUST00000227096.2 5'-nucleotidase domain containing 2, transcript variant 1 (from RefSeq NM_001374087.1) A0A2I3BR81 A0A2I3BR81_MOUSE ENSMUST00000227096.1 NM_001374087 Nt5dc2 uc007swt.1 uc007swt.2 uc007swt.3 Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Belongs to the 5'(3')-deoxyribonucleotidase family. cellular_component 5'-nucleotidase activity dephosphorylation metal ion binding uc007swt.1 uc007swt.2 uc007swt.3 
ENSMUST00000227098.2 Gm49003 ENSMUST00000227098.2 Gm49003 (from geneSymbol) ENSMUST00000227098.1 uc288vut.1 uc288vut.2 uc288vut.1 uc288vut.2 
ENSMUST00000227105.3 4933429O19Rik ENSMUST00000227105.3 4933429O19Rik (from geneSymbol) AK016985 ENSMUST00000227105.1 ENSMUST00000227105.2 uc288tik.1 uc288tik.2 uc288tik.3 uc288tik.1 uc288tik.2 uc288tik.3 
ENSMUST00000227110.2 Vmn1r217 ENSMUST00000227110.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R270) ENSMUST00000227110.1 Q8R270 Q8R270_MOUSE V1rh14 Vmn1r191 Vmn1r217 uc288lkp.1 uc288lkp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lkp.1 uc288lkp.2 
ENSMUST00000227115.2 1700047E10Rik ENSMUST00000227115.2 RIKEN cDNA 1700047E10 gene (from RefSeq NR_073363.1) ENSMUST00000227115.1 NR_073363 uc033gpn.1 uc033gpn.2 uc033gpn.1 uc033gpn.2 
ENSMUST00000227136.2 Vmn1r208 ENSMUST00000227136.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R275) ENSMUST00000227136.1 Q8R275 Q8R275_MOUSE V1rh9 Vmn1r208 Vmn1r208-ps uc288ljh.1 uc288ljh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288ljh.1 uc288ljh.2 
ENSMUST00000227141.2 Hlcs ENSMUST00000227141.2 holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase), transcript variant 1 (from RefSeq NM_001360045.2) A0A2I3BPG4 A0A2I3BPG4_MOUSE ENSMUST00000227141.1 Hlcs NM_001360045 uc008aah.1 uc008aah.2 uc008aah.3 Belongs to the biotin--protein ligase family. biotin-[acetyl-CoA-carboxylase] ligase activity cellular protein modification process uc008aah.1 uc008aah.2 uc008aah.3 
ENSMUST00000227150.2 4930478E11Rik ENSMUST00000227150.2 4930478E11Rik (from geneSymbol) BC048519 ENSMUST00000227150.1 uc288ybg.1 uc288ybg.2 uc288ybg.1 uc288ybg.2 
ENSMUST00000227154.2 Gm49187 ENSMUST00000227154.2 Gm49187 (from geneSymbol) ENSMUST00000227154.1 uc288xem.1 uc288xem.2 uc288xem.1 uc288xem.2 
ENSMUST00000227155.3 Gm35360 ENSMUST00000227155.3 Gm35360 (from geneSymbol) ENSMUST00000227155.1 ENSMUST00000227155.2 uc288tfs.1 uc288tfs.2 uc288tfs.3 uc288tfs.1 uc288tfs.2 uc288tfs.3 
ENSMUST00000227165.2 Gm49153 ENSMUST00000227165.2 Gm49153 (from geneSymbol) AK044458 ENSMUST00000227165.1 uc288tic.1 uc288tic.2 uc288tic.1 uc288tic.2 
ENSMUST00000227166.2 Gm49194 ENSMUST00000227166.2 Gm49194 (from geneSymbol) AK035137 ENSMUST00000227166.1 uc288syf.1 uc288syf.2 uc288syf.1 uc288syf.2 
ENSMUST00000227179.2 Gm48966 ENSMUST00000227179.2 Gm48966 (from geneSymbol) ENSMUST00000227179.1 uc288xnp.1 uc288xnp.2 uc288xnp.1 uc288xnp.2 
ENSMUST00000227180.3 ENSMUSG00000121409 ENSMUST00000227180.3 ENSMUSG00000121409 (from geneSymbol) ENSMUST00000227180.1 ENSMUST00000227180.2 uc288svh.1 uc288svh.2 uc288svh.3 uc288svh.1 uc288svh.2 uc288svh.3 
ENSMUST00000227182.2 Gm49198 ENSMUST00000227182.2 Gm49198 (from geneSymbol) ENSMUST00000227182.1 uc288xzk.1 uc288xzk.2 uc288xzk.1 uc288xzk.2 
ENSMUST00000227190.2 Gm9502 ENSMUST00000227190.2 Gm9502 (from geneSymbol) ENSMUST00000227190.1 LF199903 uc288tdn.1 uc288tdn.2 uc288tdn.1 uc288tdn.2 
ENSMUST00000227191.3 Ranbp3l ENSMUST00000227191.3 RAN binding protein 3-like (from RefSeq NM_198024.2) ENSMUST00000227191.1 ENSMUST00000227191.2 NM_198024 Q3V1J9 Q6PDH4 RNB3L_MOUSE uc288wwy.1 uc288wwy.2 Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner. Interacts with SMAD1, SMAD5 and SMAD8. Nucleus Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PDH4-1; Sequence=Displayed; Name=2; IsoId=Q6PDH4-2; Sequence=VSP_029895, VSP_029896; nucleus nuclear pore cytoplasm protein export from nucleus Ran GTPase binding positive regulation of GTPase activity positive regulation of myoblast differentiation negative regulation of osteoblast differentiation SMAD binding intracellular transport mesenchymal cell differentiation involved in bone development GTPase activator activity uc288wwy.1 uc288wwy.2 
ENSMUST00000227212.2 Gm49083 ENSMUST00000227212.2 Gm49083 (from geneSymbol) ENSMUST00000227212.1 uc288stc.1 uc288stc.2 uc288stc.1 uc288stc.2 
ENSMUST00000227213.3 Gm48942 ENSMUST00000227213.3 Gm48942 (from geneSymbol) ENSMUST00000227213.1 ENSMUST00000227213.2 uc288waw.1 uc288waw.2 uc288waw.3 uc288waw.1 uc288waw.2 uc288waw.3 
ENSMUST00000227218.2 Gm49768 ENSMUST00000227218.2 Gm49768 (from geneSymbol) AK043487 ENSMUST00000227218.1 uc007uzf.1 uc007uzf.2 uc007uzf.3 uc007uzf.1 uc007uzf.2 uc007uzf.3 
ENSMUST00000227224.2 B230362B09Rik ENSMUST00000227224.2 B230362B09Rik (from geneSymbol) AK046258 ENSMUST00000227224.1 uc288xhj.1 uc288xhj.2 uc288xhj.1 uc288xhj.2 
ENSMUST00000227244.2 Vmn1r206 ENSMUST00000227244.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R277) ENSMUST00000227244.1 Q8R277 Q8R277_MOUSE V1rh7 Vmn1r206 uc007psw.1 uc007psw.2 uc007psw.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc007psw.1 uc007psw.2 uc007psw.3 
ENSMUST00000227258.2 Gm49125 ENSMUST00000227258.2 Gm49125 (from geneSymbol) AK087180 ENSMUST00000227258.1 uc288taj.1 uc288taj.2 uc288taj.1 uc288taj.2 
ENSMUST00000227263.3 4930474H20Rik ENSMUST00000227263.3 RIKEN cDNA 4930474H20 gene (from RefSeq NR_045712.1) ENSMUST00000227263.1 ENSMUST00000227263.2 NR_045712 uc029smh.1 uc029smh.2 uc029smh.3 uc029smh.1 uc029smh.2 uc029smh.3 
ENSMUST00000227265.2 Vmn1r209 ENSMUST00000227265.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5NC97) ENSMUST00000227265.1 Q5NC97 Q5NC97_MOUSE Vmn1r209 Vmn1r219 uc288ljk.1 uc288ljk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288ljk.1 uc288ljk.2 
ENSMUST00000227271.2 Klhl33 ENSMUST00000227271.2 kelch-like 33, transcript variant 1 (from RefSeq NM_001370764.1) A0A2I3BRZ3 A0A2I3BRZ3_MOUSE ENSMUST00000227271.1 Klhl33 NM_001370764 uc288tne.1 uc288tne.2 uc288tne.1 uc288tne.2 
ENSMUST00000227274.3 Anxa13 ENSMUST00000227274.3 annexin A13 (from RefSeq NM_027211.2) ANX13_MOUSE ENSMUST00000227274.1 ENSMUST00000227274.2 NM_027211 Q99JG3 uc288yeh.1 uc288yeh.2 Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup. Monomer and homodimer. Apical cell membrane Cell membrane ; Lipid-anchor Cytoplasmic vesicle Note=Myristoylation anchors the protein to the membrane, but the protein also displays calcium-dependent, reversible binding to lipid membranes. Detected on the tips of microvilli in small intestine (at protein level). A pair of annexin repeats may form one binding site for calcium and phospholipid. Belongs to the annexin family. phosphatidylserine binding calcium ion binding calcium-dependent phospholipid binding nucleoplasm plasma membrane membrane apical plasma membrane extrinsic component of membrane cytoplasmic vesicle positive regulation of Golgi to plasma membrane protein transport phosphatidylglycerol binding uc288yeh.1 uc288yeh.2 
ENSMUST00000227275.2 Retreg1 ENSMUST00000227275.2 reticulophagy regulator 1, transcript variant 2 (from RefSeq NM_025459.3) E9QPM1 ENSMUST00000227275.1 Fam134b NM_025459 Q7TMY5 Q8VE91 Q9CUJ4 Q9D8Z5 RETR1_MOUSE uc007vjg.1 uc007vjg.2 uc007vjg.3 uc007vjg.4 Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720, PubMed:34338405). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720, PubMed:34338405). Active under basal conditions (By similarity). Required for collagen quality control in a LIR motif-dependent manner (PubMed:34338405). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720). Homooligomer; oligomerization is enhanced following endoplasmic reticulum stress and is mediated by the reticulon homology domain (By similarity). Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAPL1 and GABARAPL2 (PubMed:34338405). Also interacts with ATG8 family modifier protein GABARAP (By similarity). Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=4; Name=4; IsoId=Q8VE91-4; Sequence=Displayed; Name=1; IsoId=Q8VE91-1; Sequence=VSP_057838; Name=2; IsoId=Q8VE91-2; Sequence=VSP_057836; Name=3; IsoId=Q8VE91-3; Sequence=VSP_057837; Widely expressed with highest levels in brain, lung, liver, muscle and spleen (at protein level) (PubMed:34338405). Detected specifically in organelle-like intracellular structures of the small and large neurons of dorsal root ganglia (DRG) (at protein level) (PubMed:19838196, PubMed:31930741). Predominantly expressed in sensory and autonomic ganglia at embryonic day 14.5 (PubMed:19838196). The LIR motif interacts with ATG8 family proteins and is necessary to target the ER fragments to autophagosomes for lysosomal degradation. The reticulon homology domain provides capacity to bend the membrane and promotes ER scission (PubMed:26040720). It is required for homooligomerization (By similarity). This domain does not show relevant similarities with reticulon domains, preventing any domain predictions within the protein sequence. Phosphorylation at Thr-134 by CAMK2B enhances oligomerization and membrane scission and reticulophagy activity. Leads to an expanded endoplasmic reticulum. [Isoform 4]: Predicted by similarity to human,. Belongs to the RETREG family. molecular_function nucleolus endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cis-Golgi network autophagy membrane integral component of membrane nuclear body sensory perception of pain integral component of endoplasmic reticulum membrane negative regulation of neuron apoptotic process reticulophagy uc007vjg.1 uc007vjg.2 uc007vjg.3 uc007vjg.4 
ENSMUST00000227277.2 Gm48978 ENSMUST00000227277.2 Gm48978 (from geneSymbol) ENSMUST00000227277.1 uc056zde.1 uc056zde.2 uc056zde.1 uc056zde.2 
ENSMUST00000227279.2 Vmn1r42 ENSMUST00000227279.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (from UniProt Q8VBS7) ENSMUST00000227279.1 Q8VBS7 Q9EQ49 V1R42_MOUSE V1ra1 V1ra10 V1ra3 V1ra6 uc291gyc.1 uc291gyc.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Cell membrane ; Multi-pass membrane protein Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291gyc.1 uc291gyc.2 
ENSMUST00000227283.2 Vmn1r16 ENSMUST00000227283.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N775) ENSMUST00000227283.1 K7N775 K7N775_MOUSE Vmn1r16 uc291euc.1 uc291euc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291euc.1 uc291euc.2 
ENSMUST00000227291.3 1700015H07Rik ENSMUST00000227291.3 1700015H07Rik (from geneSymbol) ENSMUST00000227291.1 ENSMUST00000227291.2 uc288yar.1 uc288yar.2 uc288yar.3 uc288yar.1 uc288yar.2 uc288yar.3 
ENSMUST00000227302.2 Gm41293 ENSMUST00000227302.2 Gm41293 (from geneSymbol) ENSMUST00000227302.1 uc288xon.1 uc288xon.2 uc288xon.1 uc288xon.2 
ENSMUST00000227308.3 Gm33525 ENSMUST00000227308.3 Gm33525 (from geneSymbol) AK029885 ENSMUST00000227308.1 ENSMUST00000227308.2 uc288wck.1 uc288wck.2 uc288wck.3 uc288wck.1 uc288wck.2 uc288wck.3 
ENSMUST00000227314.2 Rbfox2 ENSMUST00000227314.2 RNA binding protein, fox-1 homolog (C. elegans) 2, transcript variant 41 (from RefSeq NM_001412027.1) ENSMUST00000227314.1 Fox2 Fxh Hrnbp2 NM_001412027 Q0R5Z7 Q0R5Z8 Q0VH84 Q537D4 Q537D5 Q8BP71 Q8BRG0 Q8R2T5 Q8VI62 Q923W8 RFOX2_MOUSE Rbm9 uc007wne.1 uc007wne.2 uc007wne.3 uc007wne.4 RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue- specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity). Interacts with ER-alpha N-terminal activation domain. Nucleus. Cytoplasm. Event=Alternative splicing; Named isoforms=9; Name=1; IsoId=Q8BP71-1; Sequence=Displayed; Name=2; Synonyms=Fox-2A; IsoId=Q8BP71-2; Sequence=VSP_030893, VSP_030897; Name=3; Synonyms=1, Fox-2F; IsoId=Q8BP71-3; Sequence=VSP_030892; Name=4; Synonyms=2, Fox-2F-S; IsoId=Q8BP71-4; Sequence=VSP_030892, VSP_030895, VSP_030896, VSP_030897, VSP_030898; Name=5; IsoId=Q8BP71-5; Sequence=VSP_030897, VSP_030899; Name=6; IsoId=Q8BP71-6; Sequence=VSP_030892, VSP_030897, VSP_030900; Name=7; Synonyms=1, F011; IsoId=Q8BP71-7; Sequence=VSP_030892, VSP_030897; Name=8; Synonyms=2, F411; IsoId=Q8BP71-8; Sequence=VSP_030892, VSP_030897, VSP_030898; Name=9; Synonyms=3, F402; IsoId=Q8BP71-9; Sequence=VSP_030892, VSP_030894; Detected in brain neurons (at protein level). Detected in heart, brain, embryo, lung, liver, kidney and ovary. Up-regulated by androgens in cultured motor neuron cells. regulation of alternative mRNA splicing, via spliceosome nucleic acid binding transcription corepressor activity RNA binding mRNA binding protein binding nucleus nucleoplasm cytoplasm cytosol mRNA processing nervous system development transcription factor binding RNA splicing regulation of definitive erythrocyte differentiation radial glia guided migration of Purkinje cell intracellular estrogen receptor signaling pathway regulation of RNA splicing negative regulation of transcription, DNA-templated dendrite morphogenesis neuromuscular process controlling balance uc007wne.1 uc007wne.2 uc007wne.3 uc007wne.4 
ENSMUST00000227320.2 Vmn1r77 ENSMUST00000227320.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PY60) E9PY60 E9PY60_MOUSE ENSMUST00000227320.1 Vmn1r77 Vmn1r78 uc291lnb.1 uc291lnb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lnb.1 uc291lnb.2 
ENSMUST00000227321.2 Gm49096 ENSMUST00000227321.2 Gm49096 (from geneSymbol) BC028264 ENSMUST00000227321.1 uc288tha.1 uc288tha.2 uc288tha.1 uc288tha.2 
ENSMUST00000227343.2 4930447J18Rik ENSMUST00000227343.2 RIKEN cDNA 4930447J18 gene (from RefSeq NR_045959.1) ENSMUST00000227343.1 NR_045959 uc029siu.1 uc029siu.2 uc029siu.3 uc029siu.1 uc029siu.2 uc029siu.3 
ENSMUST00000227345.2 BC048602 ENSMUST00000227345.2 cDNA sequence BC048602 (from RefSeq NR_045280.1) ENSMUST00000227345.1 NR_045280 uc007vmc.1 uc007vmc.2 uc007vmc.1 uc007vmc.2 
ENSMUST00000227348.2 Gm34589 ENSMUST00000227348.2 Gm34589 (from geneSymbol) AK146131 ENSMUST00000227348.1 uc288wgj.1 uc288wgj.2 uc288wgj.1 uc288wgj.2 
ENSMUST00000227351.3 Gm26782 ENSMUST00000227351.3 Gm26782 (from geneSymbol) AK015096 ENSMUST00000227351.1 ENSMUST00000227351.2 uc288tmz.1 uc288tmz.2 uc288tmz.3 uc288tmz.1 uc288tmz.2 uc288tmz.3 
ENSMUST00000227358.2 Gm49128 ENSMUST00000227358.2 Gm49128 (from geneSymbol) ENSMUST00000227358.1 uc288xcv.1 uc288xcv.2 uc288xcv.1 uc288xcv.2 
ENSMUST00000227360.2 AU022793 ENSMUST00000227360.2 predicted gene, 33251 (from RefSeq NR_155348.1) ENSMUST00000227360.1 NR_155348 uc288xvf.1 uc288xvf.2 uc288xvf.1 uc288xvf.2 
ENSMUST00000227363.2 Dpep2 ENSMUST00000227363.2 dipeptidase 2, transcript variant 3 (from RefSeq NM_176913.4) DPEP2_MOUSE ENSMUST00000227363.1 Mbd2 NM_176913 Q3TAV9 Q3TBF7 Q3TBK3 Q3TBM9 Q7TQ53 Q8C255 uc292cxz.1 uc292cxz.2 Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed:12738806). Hydrolyzes cystinyl-bis- glycine (By similarity). Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappa-B inflammatory signaling pathway. Reaction=an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid; Xref=Rhea:RHEA:48940, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869, ChEBI:CHEBI:77460; EC=3.4.13.19; Evidence= Reaction=H2O + leukotriene D4 = glycine + leukotriene E4; Xref=Rhea:RHEA:48616, ChEBI:CHEBI:15377, ChEBI:CHEBI:57305, ChEBI:CHEBI:57462, ChEBI:CHEBI:63166; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48617; Evidence=; Reaction=2 H2O + L-cystine-bis-glycine = 2 glycine + L-cystine; Xref=Rhea:RHEA:60520, ChEBI:CHEBI:15377, ChEBI:CHEBI:35491, ChEBI:CHEBI:57305, ChEBI:CHEBI:143812; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Inhibited by L-penicillamine. Kinetic parameters: KM=5 uM for LTD4 ; Homodimer; disulfide-linked. Membrane ; Lipid- anchor, GPI-anchor Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C255-1; Sequence=Displayed; Name=2; IsoId=Q8C255-2; Sequence=VSP_017853, VSP_017854, VSP_017855; Name=3; IsoId=Q8C255-3; Sequence=VSP_017852; Expressed in heart, lung, testis, spleen and skeletal muscle. Not detected in kidney and brain. Up-regulated during CVB3-induced viral myocarditis in the cardiac infiltrating macrophages. Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. According to PubMed:12738806, does not hydrolyze cystinyl-bis- glycine but data is not shown in paper. cellular_component proteolysis peptidase activity metalloexopeptidase activity metallopeptidase activity exopeptidase activity dipeptidyl-peptidase activity membrane hydrolase activity dipeptidase activity anchored component of membrane metal ion binding uc292cxz.1 uc292cxz.2 
ENSMUST00000227364.2 4921515E04Rik ENSMUST00000227364.2 RIKEN cDNA 4921515E04 gene (from RefSeq NR_045711.1) ENSMUST00000227364.1 NR_045711 uc007vih.1 uc007vih.2 uc007vih.1 uc007vih.2 
ENSMUST00000227367.2 Gm35766 ENSMUST00000227367.2 Gm35766 (from geneSymbol) ENSMUST00000227367.1 uc288thi.1 uc288thi.2 uc288thi.1 uc288thi.2 
ENSMUST00000227369.2 4930556J02Rik ENSMUST00000227369.2 4930556J02Rik (from geneSymbol) AK016147 ENSMUST00000227369.1 uc288vak.1 uc288vak.2 uc288vak.1 uc288vak.2 
ENSMUST00000227370.3 Gm49965 ENSMUST00000227370.3 Gm49965 (from geneSymbol) ENSMUST00000227370.1 ENSMUST00000227370.2 uc288sss.1 uc288sss.2 uc288sss.3 uc288sss.1 uc288sss.2 uc288sss.3 
ENSMUST00000227374.3 Gm41219 ENSMUST00000227374.3 Gm41219 (from geneSymbol) ENSMUST00000227374.1 ENSMUST00000227374.2 uc288vxr.1 uc288vxr.2 uc288vxr.3 uc288vxr.1 uc288vxr.2 uc288vxr.3 
ENSMUST00000227379.2 Mill2 ENSMUST00000227379.2 Binds to heparan sulfate proteoglycans on the surface of fibroblast (NIH-3T3) cells. (from UniProt Q8HWE5) AK137167 ENSMUST00000227379.1 MILL2_MOUSE Mill2 Q8HWE5 Q8HWE6 uc291mfz.1 uc291mfz.2 Binds to heparan sulfate proteoglycans on the surface of fibroblast (NIH-3T3) cells. Heterodimer with B2M (beta-2-microglobulin). Cell membrane ; Lipid-anchor, GPI-anchor Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long ; IsoId=Q8HWE5-1; Sequence=Displayed; Name=2; Synonyms=Short ; IsoId=Q8HWE5-2; Sequence=VSP_060927; Ubiquitously expressed in neonatal and adult tissues. N-glycosylated. Belongs to the MHC class I family. Lacks key residues involved in peptide docking and also does not require TAP (transporter involved in antigen processing) for cell surface expression, suggesting that this is a non-classical MHC class I protein which does not play a role in antigen presentation. positive regulation of T cell mediated cytotoxicity immune response-activating cell surface receptor signaling pathway antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent protein binding extracellular space plasma membrane immune response response to oxidative stress response to heat external side of plasma membrane integral component of membrane anchored component of external side of plasma membrane response to retinoic acid gamma-delta T cell activation natural killer cell lectin-like receptor binding negative regulation of defense response to virus by host uc291mfz.1 uc291mfz.2 
ENSMUST00000227382.3 Gm49304 ENSMUST00000227382.3 Gm49304 (from geneSymbol) AK030257 ENSMUST00000227382.1 ENSMUST00000227382.2 uc288tfx.1 uc288tfx.2 uc288tfx.3 uc288tfx.1 uc288tfx.2 uc288tfx.3 
ENSMUST00000227384.3 Gm36899 ENSMUST00000227384.3 Gm36899 (from geneSymbol) ENSMUST00000227384.1 ENSMUST00000227384.2 uc288xhh.1 uc288xhh.2 uc288xhh.3 uc288xhh.1 uc288xhh.2 uc288xhh.3 
ENSMUST00000227393.2 Tiaf2 ENSMUST00000227393.2 Tiaf2 (from geneSymbol) AF075717 ENSMUST00000227393.1 uc288xhi.1 uc288xhi.2 uc288xhi.1 uc288xhi.2 
ENSMUST00000227403.2 Gm49201 ENSMUST00000227403.2 Gm49201 (from geneSymbol) ENSMUST00000227403.1 LF199861 uc288sjd.1 uc288sjd.2 uc288sjd.1 uc288sjd.2 
ENSMUST00000227404.2 Otx2 ENSMUST00000227404.2 Nucleus (from UniProt Q8VD35) AK081535 ENSMUST00000227404.1 Otx2 Q8VD35 Q8VD35_MOUSE uc288thm.1 uc288thm.2 Nucleus Belongs to the paired homeobox family. Bicoid subfamily. DNA binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated multicellular organism development sequence-specific DNA binding uc288thm.1 uc288thm.2 
ENSMUST00000227415.2 Ubb-ps ENSMUST00000227415.2 Ubb-ps (from geneSymbol) ENSMUST00000227415.1 uc288tay.1 uc288tay.2 uc288tay.1 uc288tay.2 
ENSMUST00000227417.2 Gm49285 ENSMUST00000227417.2 Gm49285 (from geneSymbol) ENSMUST00000227417.1 uc288xkq.1 uc288xkq.2 uc288xkq.1 uc288xkq.2 
ENSMUST00000227418.2 Vmn1r33 ENSMUST00000227418.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2E0) E9PZF1 ENSMUST00000227418.1 G3X9L2 G5E8L4 G5E914 Q8R2E0 Q8R2E0_MOUSE V1rc14 Vmn1r10 Vmn1r33 uc009ceq.1 uc009ceq.2 uc009ceq.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009ceq.1 uc009ceq.2 uc009ceq.3 
ENSMUST00000227419.2 Gm49307 ENSMUST00000227419.2 Gm49307 (from geneSymbol) AK035812 ENSMUST00000227419.1 uc288tgj.1 uc288tgj.2 uc288tgj.1 uc288tgj.2 
ENSMUST00000227421.2 Vmn1r13 ENSMUST00000227421.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt G5E8I3) ENSMUST00000227421.1 G5E8I3 G5E8I3_MOUSE Vmn1r13 uc291etu.1 uc291etu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. hematopoietic progenitor cell differentiation G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291etu.1 uc291etu.2 
ENSMUST00000227423.2 Gm49014 ENSMUST00000227423.2 Gm49014 (from geneSymbol) AK089020 ENSMUST00000227423.1 uc288yhz.1 uc288yhz.2 uc288yhz.1 uc288yhz.2 
ENSMUST00000227438.2 Gm49156 ENSMUST00000227438.2 Gm49156 (from geneSymbol) AK044476 ENSMUST00000227438.1 uc288tid.1 uc288tid.2 uc288tid.1 uc288tid.2 
ENSMUST00000227451.3 Gm33299 ENSMUST00000227451.3 Gm33299 (from geneSymbol) ENSMUST00000227451.1 ENSMUST00000227451.2 uc288wof.1 uc288wof.2 uc288wof.3 uc288wof.1 uc288wof.2 uc288wof.3 
ENSMUST00000227452.2 Gm49233 ENSMUST00000227452.2 Gm49233 (from geneSymbol) ENSMUST00000227452.1 uc288xik.1 uc288xik.2 uc288xik.1 uc288xik.2 
ENSMUST00000227456.2 Vmn1r44 ENSMUST00000227456.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (from UniProt Q9EQ47) B9EKS6 ENSMUST00000227456.1 Q3B815 Q3B816 Q8R2E5 Q8VIC5 Q9EQ47 V1R44_MOUSE V1ra10 V1rb11 V1rb4 uc291gyk.1 uc291gyk.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Cell membrane ; Multi-pass membrane protein Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Belongs to the G-protein coupled receptor 1 family. Sequence=AAL47870.1; Type=Frameshift; Evidence=; G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291gyk.1 uc291gyk.2 
ENSMUST00000227458.2 Hnrnpc ENSMUST00000227458.2 heterogeneous nuclear ribonucleoprotein C, transcript variant 23 (from RefSeq NM_001424479.1) ENSMUST00000227458.1 HNRPC_MOUSE Hnrpc NM_001424479 Q3TLB5 Q501Q3 Q8C2G5 Q99KE2 Q9CQT3 Q9CY83 Q9Z204 uc007toc.1 uc007toc.2 uc007toc.3 uc007toc.4 Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing. Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with DHX9; this interaction is direct, enhanced probably by their concomitant binding to RNA and mediates the attachment to actin filaments (By similarity). Interacts with PPIA/CYPA (By similarity). Nucleus Note=Component of ribonucleosomes. Event=Alternative splicing; Named isoforms=5; Name=C2; IsoId=Q9Z204-1; Sequence=Displayed; Name=C1; IsoId=Q9Z204-2; Sequence=VSP_005832; Name=3; IsoId=Q9Z204-3; Sequence=VSP_005832, VSP_005833; Name=4; IsoId=Q9Z204-4; Sequence=VSP_005832, VSP_019227; Name=5; IsoId=Q9Z204-5; Sequence=VSP_005833; Phosphorylated on Ser-268 and Ser-306 in resting cells. Sumoylated. Sumoylation reduces affinity for mRNA. Ubiquitinated and degraded after nucleo-cytoplasmic transport by YWHAE. Belongs to the RRM HNRPC family. RALY subfamily. mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding enzyme inhibitor activity nucleus nucleoplasm spliceosomal complex telomerase holoenzyme complex cytosol mRNA processing poly(U) RNA binding RNA splicing actin cytoskeleton protein domain specific binding negative regulation of telomere maintenance via telomerase macromolecular complex identical protein binding ribonucleoprotein complex binding negative regulation of catalytic activity pronucleus telomerase RNA binding 3'-UTR-mediated mRNA stabilization catalytic step 2 spliceosome negative regulation of mRNA modification N6-methyladenosine-containing RNA binding nucleoplasmic periphery of the nuclear pore complex deaminase binding uc007toc.1 uc007toc.2 uc007toc.3 uc007toc.4 
ENSMUST00000227460.2 Gm49300 ENSMUST00000227460.2 Gm49300 (from geneSymbol) AK044314 ENSMUST00000227460.1 uc288xjw.1 uc288xjw.2 uc288xjw.1 uc288xjw.2 
ENSMUST00000227472.2 Gm31282 ENSMUST00000227472.2 Gm31282 (from geneSymbol) ENSMUST00000227472.1 uc288wwg.1 uc288wwg.2 uc288wwg.1 uc288wwg.2 
ENSMUST00000227474.2 Gm49089 ENSMUST00000227474.2 Gm49089 (from geneSymbol) ENSMUST00000227474.1 LF200208 uc007vle.1 uc007vle.2 uc007vle.1 uc007vle.2 
ENSMUST00000227478.2 Hsf1 ENSMUST00000227478.2 heat shock factor 1, transcript variant 3 (from RefSeq NM_001331154.1) ENSMUST00000227478.1 HSF1_MOUSE Hsf1 NM_001331154 O70462 P38532 uc056yzg.1 uc056yzg.2 Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA- binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes. Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival. Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form. Binds to inverted 5'-NGAAN-3' pentamer DNA sequences. Binds to chromatin at heat shock gene promoters. Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH- dependent reductase DHRS2 (By similarity). Binds the promoter region upstream of exon 1 of Mpv17l to activate expression of the M-LPS isoform which is involved in metabolism of reactive oxygen species (PubMed:20231359). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells. Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner. Plays a role in nuclear export of stress-induced HSP70 mRNA. Plays a role in the regulation of mitotic progression. Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner. Involved in stress- induced cancer cell proliferation in a IER5-dependent manner. Monomer; cytoplasmic latent and transcriptionally inactive monomeric form in unstressed cells. Homotrimer; in response to stress, such as heat shock, homotrimerizes and translocates into the nucleus, binds to heat shock element (HSE) sequences in promoter of heat shock protein (HSP) genes and acquires transcriptional ability. Interacts (via monomeric form) with FKBP4; this interaction occurs in unstressed cells. Associates (via monomeric form) with HSP90 proteins in a multichaperone complex in unnstressed cell; this association maintains HSF1 in a non-DNA-binding and transcriptional inactive form by preventing HSF1 homotrimerization. Homotrimeric transactivation activity is modulated by protein-protein interactions and post- translational modifications. Interacts with HSP90AA1; this interaction is decreased in a IER5-dependent manner, promoting HSF1 accumulation in the nucleus, homotrimerization and DNA-binding activities. Part (via regulatory domain in the homotrimeric form) of a large heat shock- induced HSP90-dependent multichaperone complex at least composed of FKBP4, FKBP5, HSP90 proteins, PPID, PPP5C and PTGES3; this association maintains the HSF1 homotrimeric DNA-bound form in a transcriptionally inactive form. Interacts with BAG3 (via BAG domain); this interaction occurs in normal and heat-shocked cells promoting nuclear shuttling of HSF1 in a BAG3-dependent manner. Interacts (via homotrimeric and hyperphosphorylated form) with FKBP4; this interaction occurs upon heat shock in a HSP90-dependent multichaperone complex. Interacts (via homotrimeric form preferentially) with EEF1A proteins. In heat shocked cells, stress-denatured proteins compete with HSF1 homotrimeric DNA- bound form for association of the HSP90-dependent multichaperone complex, and hence alleviating repression of HSF1-mediated transcriptional activity. Interacts (via homotrimeric form preferentially) with DAXX; this interaction relieves homotrimeric HSF1 from repression of its transcriptional activity by HSP90-dependent multichaperone complex upon heat shock. Interacts (via D domain and preferentially with hyperphosphorylated form) with JNK1; this interaction occurs under both normal growth conditions and immediately upon heat shock. Interacts (via D domain and preferentially with hyperphosphorylated form) with MAPK3; this interaction occurs upon heat shock. Interacts with IER5 (via central region); this interaction promotes PPP2CA-induced dephosphorylation on Ser-121, Ser-307, Ser-314 and Thr-323 and HSF1 transactivation activity. Found in a ribonucleoprotein complex composed of the HSF1 homotrimeric form, translation elongation factor eEF1A proteins and non-coding RNA heat shock RNA-1 (HSR1); this complex occurs upon heat shock and stimulates HSF1 DNA-binding activity. Interacts (via transactivation domain) with HSPA1A/HSP70 and DNAJB1; these interactions result in the inhibition of heat shock- and HSF1-induced transcriptional activity during the attenuation and recovery phase from heat shock. Interacts (via Ser-303 and Ser-307 phosphorylated form) with YWHAE; this interaction promotes HSF1 sequestration in the cytoplasm in an ERK-dependent manner. Found in a complex with IER5 and PPP2CA. Interacts with TPR; this interaction increases upon heat shock and stimulates export of HSP70 mRNA. Interacts with SYMPK (via N-terminus) and CSTF2; these interactions occur upon heat shock. Interacts (via transactivation domain) with HSPA8. Interacts with EEF1D; this interaction occurs at heat shock promoter element (HSE) sequences. Interacts with MAPKAPK2. Interacts with PRKACA/PKA. Interacts (via transactivation domain) with GTF2A2. Interacts (via transactivation domain) with GTF2B. Interacts (via transactivation domain) with TBP. Interacts with CDK9, CCNT1 and EP300. Interacts (via N-terminus) with XRCC5 (via N-terminus) and XRCC6 (via N-terminus); these interactions are direct and prevent XRCC5/XRCC6 heterodimeric binding and non-homologous end joining (NHEJ) repair activities induced by ionizing radiation (IR). Interacts with PLK1; this interaction occurs during the early mitotic period, increases upon heat shock but does not modulate neither HSF1 homotrimerization and DNA-binding activities. Interacts (via Ser-216 phosphorylated form) with CDC20; this interaction occurs in mitosis in a MAD2L1-dependent manner and prevents PLK1-stimulated degradation of HSF1 by blocking the recruitment of the SCF(BTRC) ubiquitin ligase complex. Interacts with MAD2L1; this interaction occurs in mitosis. Interacts with BTRC; this interaction occurs during mitosis, induces its ubiquitin-dependent degradation following stimulus-dependent phosphorylation at Ser-216, a process inhibited by CDC20. Interacts with HSP90AA1 and HSP90AB1. Forms a complex with TTC5/STRAP and p300/EP300; these interactions augment chromatin-bound HSF1 and p300/EP300 histone acetyltransferase activity (By similarity). Nucleus Cytoplasm Nucleus, nucleoplasm Cytoplasm, perinuclear region Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Chromosome, centromere, kinetochore Note=The monomeric form is cytoplasmic in unstressed cells (PubMed:26159920). Predominantly nuclear protein in both unstressed and heat shocked cells. Translocates in the nucleus upon heat shock. Nucleocytoplasmic shuttling protein. Colocalizes with IER5 in the nucleus. Colocalizes with BAG3 to the nucleus upon heat stress. Localizes in subnuclear granules called nuclear stress bodies (nSBs) upon heat shock. Colocalizes with SYMPK and SUMO1 in nSBs upon heat shock. Colocalizes with PRKACA/PKA in the nucleus and nSBs upon heat shock. Relocalizes from the nucleus to the cytoplasm during the attenuation and recovery phase period of the heat shock response. Translocates in the cytoplasm in a YWHAE- and XPO1/CRM1-dependent manner. Together with histone H2AX, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR). Colocalizes with calcium-responsive transactivator SS18L1 at kinetochore region on the mitotic chromosomes. Colocalizes with gamma tubulin at centrosome. Localizes at spindle pole in metaphase. Colocalizes with PLK1 at spindle poles during prometaphase. Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=P38532-1; Sequence=Displayed; Name=1; IsoId=P38532-2; Sequence=VSP_002416; In unstressed cells, spontaneous homotrimerization is inhibited. Intramolecular interactions between the hydrophobic repeat HR-A/B and HR-C regions are necessary to maintain HSF1 in the inactive, monomeric conformation. Furthermore, intramolecular interactions between the regulatory domain and the nonadjacent transactivation domain prevents transcriptional activation, a process that is relieved upon heat shock. The regulatory domain is necessary for full repression of the transcriptional activation domain in unstressed cells through its phosphorylation on Ser-303 and Ser-307. In heat stressed cells, HSF1 homotrimerization occurs through formation of a three-stranded coiled-coil structure generated by intermolecular interactions between HR-A/B regions allowing DNA-binding activity. The D domain is necessary for translocation to the nucleus, interaction with JNK1 and MAPK3 and efficient JNK1- and MAPK3-dependent phosphorylation. The regulatory domain confers heat shock inducibility on the transcriptional transactivation domain. The regulatory domain is necessary for transcriptional activation through its phosphorylation on Ser-230 upon heat shock. 9aaTAD is a transactivation motif present in a large number of yeast and animal transcription factors. Phosphorylated. Phosphorylated in unstressed cells; this phosphorylation is constitutive and implicated in the repression of HSF1 transcriptional activity. Phosphorylated on Ser-121 by MAPKAPK2; this phosphorylation promotes interaction with HSP90 proteins and inhibits HSF1 homotrimerization, DNA-binding and transactivation activities. Phosphorylation on Ser-303 by GSK3B/GSK3-beat and on Ser- 307 by MAPK3 within the regulatory domain is involved in the repression of HSF1 transcriptional activity and occurs in a RAF1-dependent manner. Phosphorylation on Ser-303 and Ser-307 increases HSF1 nuclear export in a YWHAE- and XPO1/CRM1-dependent manner. Phosphorylation on Ser-307 is a prerequisite for phosphorylation on Ser-303. According to, Ser-303 is not phosphorylated in unstressed cells. Phosphorylated on Ser-415 by PLK1; phosphorylation promotes nuclear translocation upon heat shock. Hyperphosphorylated upon heat shock and during the attenuation and recovery phase period of the heat shock response. Phosphorylated on Thr-142; this phosphorylation increases HSF1 transactivation activity upon heat shock. Phosphorylation on Ser-230 by CAMK2A; this phosphorylation enhances HSF1 transactivation activity upon heat shock. Phosphorylation on Ser-326 by MAPK12; this phosphorylation enhances HSF1 nuclear translocation, homotrimerization and transactivation activities upon heat shock. Phosphorylated on Ser-320 by PRKACA/PKA; this phosphorylation promotes nuclear localization and transcriptional activity upon heat shock. Phosphorylated by MAPK8; this phosphorylation occurs upon heat shock, induces HSF1 translocation into nuclear stress bodies and negatively regulates transactivation activity. Neither basal nor stress-inducible phosphorylation on Ser-230, Ser-292, Ser-303, Ser- 307, Ser-314, Ser-319, Ser-320, Thr-323, Ser-326, Ser-338, Ser-345, Ser-364 and Thr-365 within the regulatory domain is involved in the regulation of HSF1 subcellular localization or DNA-binding activity; however, it negatively regulates HSF1 transactivation activity. Phosphorylated on Ser-216 by PLK1 in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex inducing HSF1 degradation, and hence mitotic progression. Dephosphorylated on Ser- 121, Ser-307, Ser-314 and Thr-323 by phosphatase PPP2CA in an IER5- dependent manner, leading to HSF1-mediated transactivation activity. Sumoylated with SUMO1 and SUMO2 upon heat shock in a ERK2- dependent manner. Sumoylated by SUMO1 on Lys-298; sumoylation occurs upon heat shock and promotes its localization to nuclear stress bodies and DNA-binding activity. Phosphorylation on Ser-303 and Ser-307 is probably a prerequisite for sumoylation. Acetylated on Lys-118; this acetylation is decreased in a IER5- dependent manner. Acetylated on Lys-118, Lys-208 and Lys-298; these acetylations occur in a EP300-dependent manner. Acetylated on Lys-80; this acetylation inhibits DNA-binding activity upon heat shock. Deacetylated on Lys-80 by SIRT1; this deacetylation increases DNA- binding activity. Ubiquitinated by SCF(BTRC) and degraded following stimulus- dependent phosphorylation at Ser-216 by PLK1 in mitosis. Polyubiquitinated. Undergoes proteasomal degradation upon heat shock and during the attenuation and recovery phase period of the heat shock response. Belongs to the HSF family. negative regulation of transcription from RNA polymerase II promoter MAPK cascade chromosome, centromeric region kinetochore condensed chromosome kinetochore euchromatin heterochromatin spindle pole RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development embryonic placenta development DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm chromosome cytoplasm centrosome microtubule organizing center cytosol cytoskeleton DNA repair regulation of transcription, DNA-templated mRNA processing protein phosphorylation defense response cellular response to DNA damage stimulus female meiotic division spermatogenesis response to nutrient positive regulation of cell proliferation negative regulation of cell proliferation mRNA transcription response to heat response to organonitrogen compound positive regulation of gene expression negative regulation of gene expression negative regulation of cardiac muscle cell apoptotic process response to organic cyclic compound response to activity PML body protein kinase binding heat shock protein binding chromatin DNA binding response to estradiol response to lipopolysaccharide negative regulation of tumor necrosis factor production macromolecular complex response to testosterone cellular response to heat cellular response to unfolded protein cellular macromolecular complex assembly cellular response to drug cellular response to potassium ion positive regulation of multicellular organism growth positive regulation of tyrosine phosphorylation of STAT protein identical protein binding response to amino acid positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of protein heterodimerization activity sequence-specific DNA binding protein self-association pronucleus positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity perinuclear region of cytoplasm mRNA transport protein homooligomerization Hsp90 protein binding embryonic process involved in female pregnancy positive regulation of transcription from RNA polymerase II promoter in response to heat stress translation elongation factor binding protein homotrimerization cellular response to hydrogen peroxide cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to cadmium ion cellular response to copper ion cellular response to estradiol stimulus cellular response to organic cyclic compound cellular response to radiation cellular response to gamma radiation cellular response to diamide negative regulation of inclusion body assembly positive regulation of inclusion body assembly nuclear stress granule mitotic spindle pole STAT family protein binding sequence-specific single stranded DNA binding regulation of cellular response to heat positive regulation of mRNA polyadenylation negative regulation of neuron death response to peptide positive regulation of apoptotic DNA fragmentation cellular response to sodium arsenite cellular response to angiotensin positive regulation of microtubule binding cellular response to nitroglycerin cellular response to L-glutamine promoter-specific chromatin binding ribonucleoprotein complex response to hypobaric hypoxia response to psychosocial stress negative regulation of double-strand break repair via nonhomologous end joining uc056yzg.1 uc056yzg.2 
ENSMUST00000227485.2 Gm49130 ENSMUST00000227485.2 Gm49130 (from geneSymbol) ENSMUST00000227485.1 uc288ujh.1 uc288ujh.2 uc288ujh.1 uc288ujh.2 
ENSMUST00000227490.2 Gm49268 ENSMUST00000227490.2 Gm49268 (from geneSymbol) ENSMUST00000227490.1 uc288xgz.1 uc288xgz.2 uc288xgz.1 uc288xgz.2 
ENSMUST00000227495.4 9030619P08Rik ENSMUST00000227495.4 9030619P08Rik (from geneSymbol) BC087965 ENSMUST00000227495.1 ENSMUST00000227495.2 ENSMUST00000227495.3 uc288ytg.1 uc288ytg.2 uc288ytg.3 uc288ytg.4 uc288ytg.1 uc288ytg.2 uc288ytg.3 uc288ytg.4 
ENSMUST00000227496.2 Cdh12 ENSMUST00000227496.2 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). (from UniProt Q5RJH3) BC086655 CAD12_MOUSE ENSMUST00000227496.1 Q5RJH3 uc007vip.1 uc007vip.2 uc007vip.3 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). Cell membrane ; Single-pass type I membrane protein Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. cell morphogenesis calcium ion binding plasma membrane cell-cell adherens junction cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cytoskeletal protein binding cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex adherens junction organization protein homodimerization activity cell-cell adhesion mediated by cadherin cadherin binding metal ion binding cell-cell adhesion uc007vip.1 uc007vip.2 uc007vip.3 
ENSMUST00000227525.2 Gm49289 ENSMUST00000227525.2 Gm49289 (from geneSymbol) ENSMUST00000227525.1 uc288voa.1 uc288voa.2 uc288voa.1 uc288voa.2 
ENSMUST00000227527.2 Gm49175 ENSMUST00000227527.2 Gm49175 (from geneSymbol) ENSMUST00000227527.1 uc288vrb.1 uc288vrb.2 uc288vrb.1 uc288vrb.2 
ENSMUST00000227529.3 Gm41276 ENSMUST00000227529.3 Gm41276 (from geneSymbol) ENSMUST00000227529.1 ENSMUST00000227529.2 uc288xcq.1 uc288xcq.2 uc288xcq.3 uc288xcq.1 uc288xcq.2 uc288xcq.3 
ENSMUST00000227530.2 Vmn1r79 ENSMUST00000227530.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R285) ENSMUST00000227530.1 Q8R285 Q8R285_MOUSE V1rg10 Vmn1r79 uc291lnm.1 uc291lnm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lnm.1 uc291lnm.2 
ENSMUST00000227552.2 Gm49076 ENSMUST00000227552.2 Gm49076 (from geneSymbol) ENSMUST00000227552.1 uc288tre.1 uc288tre.2 uc288tre.1 uc288tre.2 
ENSMUST00000227553.3 Gm10076 ENSMUST00000227553.3 Gm10076 (from geneSymbol) ENSMUST00000227553.1 ENSMUST00000227553.2 uc288wit.1 uc288wit.2 uc288wit.3 uc288wit.1 uc288wit.2 uc288wit.3 
ENSMUST00000227555.2 Vmn1r39 ENSMUST00000227555.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt G3UWE6) ENSMUST00000227555.1 G3UWE6 G3UWE6_MOUSE G3X9L1 Vmn1r39 uc291fdz.1 uc291fdz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291fdz.1 uc291fdz.2 
ENSMUST00000227556.3 Lmbrd2 ENSMUST00000227556.3 LMBR1 domain containing 2, transcript variant 5 (from RefSeq NR_184843.1) ENSMUST00000227556.1 ENSMUST00000227556.2 LMBD2_MOUSE Lmbrd2 NR_184843 Q3U5C1 Q501M6 Q8BQ06 Q8C561 uc007vfj.1 uc007vfj.2 uc007vfj.3 Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1. Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8C561-1; Sequence=Displayed; Name=2; IsoId=Q8C561-2; Sequence=VSP_027569; Name=3; IsoId=Q8C561-3; Sequence=VSP_027568; Belongs to the LIMR family. molecular_function biological_process membrane integral component of membrane adrenergic receptor signaling pathway uc007vfj.1 uc007vfj.2 uc007vfj.3 
ENSMUST00000227557.3 Gm5144 ENSMUST00000227557.3 predicted gene 5144 (from RefSeq NR_131059.1) ENSMUST00000227557.1 ENSMUST00000227557.2 NR_131059 uc007vhh.1 uc007vhh.2 uc007vhh.3 uc007vhh.4 uc007vhh.1 uc007vhh.2 uc007vhh.3 uc007vhh.4 
ENSMUST00000227565.3 Gm41206 ENSMUST00000227565.3 Gm41206 (from geneSymbol) ENSMUST00000227565.1 ENSMUST00000227565.2 uc288vot.1 uc288vot.2 uc288vot.3 uc288vot.1 uc288vot.2 uc288vot.3 
ENSMUST00000227566.2 Vmn1r90 ENSMUST00000227566.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BR38) A0A2I3BR38 A0A2I3BR38_MOUSE AK016782 ENSMUST00000227566.1 Vmn1r90 uc291luy.1 uc291luy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291luy.1 uc291luy.2 
ENSMUST00000227597.2 Gm49087 ENSMUST00000227597.2 Gm49087 (from geneSymbol) AK079750 ENSMUST00000227597.1 uc288stp.1 uc288stp.2 uc288stp.1 uc288stp.2 
ENSMUST00000227609.2 C230086J09Rik ENSMUST00000227609.2 C230086J09Rik (from geneSymbol) ENSMUST00000227609.1 uc288wbl.1 uc288wbl.2 uc288wbl.1 uc288wbl.2 
ENSMUST00000227616.2 Gm49172 ENSMUST00000227616.2 Gm49172 (from geneSymbol) ENSMUST00000227616.1 uc289awe.1 uc289awe.2 uc289awe.1 uc289awe.2 
ENSMUST00000227624.3 Gm41322 ENSMUST00000227624.3 Gm41322 (from geneSymbol) ENSMUST00000227624.1 ENSMUST00000227624.2 uc288yae.1 uc288yae.2 uc288yae.3 uc288yae.1 uc288yae.2 uc288yae.3 
ENSMUST00000227628.2 Gm49238 ENSMUST00000227628.2 Gm49238 (from geneSymbol) ENSMUST00000227628.1 LF314521 uc288weu.1 uc288weu.2 uc288weu.1 uc288weu.2 
ENSMUST00000227629.2 Vmn1r1 ENSMUST00000227629.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PVR6) E9PVR6 E9PVR6_MOUSE ENSMUST00000227629.1 Vmn1r1 uc287opa.1 uc287opa.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc287opa.1 uc287opa.2 
ENSMUST00000227631.2 Vmn1r6 ENSMUST00000227631.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BQJ7) A0A2I3BQJ7 A0A2I3BQJ7_MOUSE ENSMUST00000227631.1 Vmn1r6 uc291etf.1 uc291etf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291etf.1 uc291etf.2 
ENSMUST00000227632.3 ENSMUSG00000121405 ENSMUST00000227632.3 ENSMUSG00000121405 (from geneSymbol) ENSMUST00000227632.1 ENSMUST00000227632.2 uc288srt.1 uc288srt.2 uc288srt.3 uc288srt.1 uc288srt.2 uc288srt.3 
ENSMUST00000227636.2 Gm49297 ENSMUST00000227636.2 Gm49297 (from geneSymbol) ENSMUST00000227636.1 uc288wqu.1 uc288wqu.2 uc288wqu.1 uc288wqu.2 
ENSMUST00000227641.3 Gm30691 ENSMUST00000227641.3 Gm30691 (from geneSymbol) ENSMUST00000227641.1 ENSMUST00000227641.2 uc288yjw.1 uc288yjw.2 uc288yjw.3 uc288yjw.1 uc288yjw.2 uc288yjw.3 
ENSMUST00000227649.2 Gm48918 ENSMUST00000227649.2 Gm48918 (from geneSymbol) ENSMUST00000227649.1 uc288xfb.1 uc288xfb.2 uc288xfb.1 uc288xfb.2 
ENSMUST00000227652.2 Vmn1r214 ENSMUST00000227652.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R279) ENSMUST00000227652.1 Q8R279 Q8R279_MOUSE V1rh5 Vmn1r214 uc288lke.1 uc288lke.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. hematopoietic progenitor cell differentiation G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lke.1 uc288lke.2 
ENSMUST00000227691.2 Ebag9 ENSMUST00000227691.2 estrogen receptor-binding fragment-associated gene 9, transcript variant 4 (from RefSeq NM_001411929.1) ENSMUST00000227691.1 NM_001411929 Q0VET4 Q3TVG2 Q3TWY4 Q9D0V7 Q9QYD0 RCAS1_MOUSE Rcas1 uc007vpz.1 uc007vpz.2 uc007vpz.3 uc007vpz.4 May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. Homodimer. Golgi apparatus membrane ; Single- pass type III membrane protein Note=Predominantly located in the Golgi. Widely expressed. Expressed in heart, brain, spleen, liver, kidney and testis. Expressed in the developing embryo. By 17-beta-estradiol (E2). The coiled coil domain is necessary for the homodimerization. Golgi membrane Golgi apparatus apoptotic process membrane integral component of membrane secretory granule uc007vpz.1 uc007vpz.2 uc007vpz.3 uc007vpz.4 
ENSMUST00000227703.3 Gm49116 ENSMUST00000227703.3 Gm49116 (from geneSymbol) ENSMUST00000227703.1 ENSMUST00000227703.2 uc288xcg.1 uc288xcg.2 uc288xcg.3 uc288xcg.1 uc288xcg.2 uc288xcg.3 
ENSMUST00000227704.3 Gm48925 ENSMUST00000227704.3 Gm48925 (from geneSymbol) AK076852 ENSMUST00000227704.1 ENSMUST00000227704.2 uc007ube.1 uc007ube.2 uc007ube.3 uc007ube.1 uc007ube.2 uc007ube.3 
ENSMUST00000227706.2 Vmn1r8 ENSMUST00000227706.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2C2) ENSMUST00000227706.1 Q8R2C2 Q8R2C2_MOUSE V1rb2 V1rc32 Vmn1r8 uc291etj.1 uc291etj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291etj.1 uc291etj.2 
ENSMUST00000227707.2 Gm49025 ENSMUST00000227707.2 Gm49025 (from geneSymbol) ENSMUST00000227707.1 uc288ska.1 uc288ska.2 uc288ska.1 uc288ska.2 
ENSMUST00000227711.2 Gm49000 ENSMUST00000227711.2 Gm49000 (from geneSymbol) ENSMUST00000227711.1 uc288wkk.1 uc288wkk.2 uc288wkk.1 uc288wkk.2 
ENSMUST00000227713.2 Vmn1r167 ENSMUST00000227713.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt G3UW71) ENSMUST00000227713.1 G3UW71 G3UW71_MOUSE Vmn1r167 uc291mqt.1 uc291mqt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291mqt.1 uc291mqt.2 
ENSMUST00000227714.2 9430068D22Rik ENSMUST00000227714.2 9430068D22Rik (from geneSymbol) AK020479 ENSMUST00000227714.1 uc288xgx.1 uc288xgx.2 uc288xgx.1 uc288xgx.2 
ENSMUST00000227716.2 Gm33450 ENSMUST00000227716.2 Gm33450 (from geneSymbol) ENSMUST00000227716.1 uc288wbt.1 uc288wbt.2 uc288wbt.1 uc288wbt.2 
ENSMUST00000227721.2 2310069G16Rik ENSMUST00000227721.2 2310069G16Rik (from geneSymbol) AK080719 ENSMUST00000227721.1 uc007vqi.1 uc007vqi.2 uc007vqi.3 uc007vqi.1 uc007vqi.2 uc007vqi.3 
ENSMUST00000227729.2 Morn2 ENSMUST00000227729.2 Morn2 (from geneSymbol) A0A2I3BRK9 A0A2I3BRK9_MOUSE AY367765 ENSMUST00000227729.1 Morn2 uc008drd.1 uc008drd.2 uc008drd.3 uc008drd.4 uc008drd.1 uc008drd.2 uc008drd.3 uc008drd.4 
ENSMUST00000227730.2 ENSMUSG00000121709 ENSMUST00000227730.2 ENSMUSG00000121709 (from geneSymbol) AK133090 ENSMUST00000227730.1 uc288vzk.1 uc288vzk.2 uc288vzk.1 uc288vzk.2 
ENSMUST00000227731.3 Gm49240 ENSMUST00000227731.3 Gm49240 (from geneSymbol) ENSMUST00000227731.1 ENSMUST00000227731.2 uc288xav.1 uc288xav.2 uc288xav.3 uc288xav.1 uc288xav.2 uc288xav.3 
ENSMUST00000227732.2 Gm49519 ENSMUST00000227732.2 Gm49519 (from geneSymbol) ENSMUST00000227732.1 KY467698 uc288tgy.1 uc288tgy.2 uc288tgy.1 uc288tgy.2 
ENSMUST00000227739.2 Gm46516 ENSMUST00000227739.2 Gm46516 (from geneSymbol) ENSMUST00000227739.1 uc288yci.1 uc288yci.2 uc288yci.1 uc288yci.2 
ENSMUST00000227749.2 Vmn1r35 ENSMUST00000227749.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2E2) ENSMUST00000227749.1 Q8R2E2 Q8R2E2_MOUSE V1rc12 Vmn1r35 uc291fdf.1 uc291fdf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291fdf.1 uc291fdf.2 
ENSMUST00000227755.2 Vmn1r80 ENSMUST00000227755.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N1Z3) ENSMUST00000227755.1 L7N1Z3 L7N1Z3_MOUSE Vmn1r80 uc291lnr.1 uc291lnr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lnr.1 uc291lnr.2 
ENSMUST00000227757.2 Gm49216 ENSMUST00000227757.2 Gm49216 (from geneSymbol) ENSMUST00000227757.1 uc288xkb.1 uc288xkb.2 uc288xkb.1 uc288xkb.2 
ENSMUST00000227758.2 Gm49041 ENSMUST00000227758.2 Gm49041 (from geneSymbol) ENSMUST00000227758.1 uc291dqq.1 uc291dqq.2 uc291dqq.1 uc291dqq.2 
ENSMUST00000227759.2 Matn2 ENSMUST00000227759.2 matrilin 2, transcript variant 1 (from RefSeq NM_001358780.1) E9QPK9 ENSMUST00000227759.1 MATN2_MOUSE NM_001358780 O08746 Q8R542 uc288xmd.1 uc288xmd.2 Involved in matrix assembly. Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O08746-1; Sequence=Displayed; Name=2; IsoId=O08746-2; Sequence=VSP_041771; Detected in a variety of organs, including calvaria, uterus, heart and brain, as well as fibroblast and osteoblast cell lines. neuron migration growth plate cartilage chondrocyte morphogenesis extracellular matrix structural constituent calcium ion binding extracellular region basement membrane extracellular space axon guidance glial cell migration extracellular matrix dendrite regeneration neuron projection development response to axon injury uc288xmd.1 uc288xmd.2 
ENSMUST00000227764.2 Rnase12 ENSMUST00000227764.2 Belongs to the pancreatic ribonuclease family. (from UniProt W0UUY1) ENSMUST00000227764.1 Rai1 Rnase12 W0UUY1 W0UUY1_MOUSE uc288tog.1 uc288tog.2 Belongs to the pancreatic ribonuclease family. nucleic acid binding uc288tog.1 uc288tog.2 
ENSMUST00000227769.2 Gm2675 ENSMUST00000227769.2 Gm2675 (from geneSymbol) AK035720 ENSMUST00000227769.1 uc288yej.1 uc288yej.2 uc288yej.1 uc288yej.2 
ENSMUST00000227771.3 4930430F21Rik ENSMUST00000227771.3 RIKEN cDNA 4930430F21 gene (from RefSeq NR_045186.1) ENSMUST00000227771.1 ENSMUST00000227771.2 NR_045186 uc029sof.1 uc029sof.2 uc029sof.3 uc029sof.4 uc029sof.1 uc029sof.2 uc029sof.3 uc029sof.4 
ENSMUST00000227772.2 9430069I07Rik ENSMUST00000227772.2 RIKEN cDNA 9430069I07 gene (from RefSeq NM_001256161.1) 9430069I07Rik ENSMUST00000227772.1 NM_001256161 Q9CX21 Q9CX21_MOUSE uc007vlp.1 uc007vlp.2 uc007vlp.3 molecular_function cellular_component biological_process uc007vlp.1 uc007vlp.2 uc007vlp.3 
ENSMUST00000227773.2 Gm10847 ENSMUST00000227773.2 Gm10847 (from geneSymbol) AK140889 ENSMUST00000227773.1 uc288vrq.1 uc288vrq.2 uc288vrq.1 uc288vrq.2 
ENSMUST00000227778.2 Dpep2nb ENSMUST00000227778.2 Dpep2nb (from geneSymbol) A0A2I3BPW5 A0A2I3BPW5_MOUSE Dpep2nb ENSMUST00000227778.1 uc292cye.1 uc292cye.2 uc292cye.1 uc292cye.2 
ENSMUST00000227782.2 Gm49022 ENSMUST00000227782.2 Gm49022 (from geneSymbol) ENSMUST00000227782.1 uc288uky.1 uc288uky.2 uc288uky.1 uc288uky.2 
ENSMUST00000227795.2 Gm30083 ENSMUST00000227795.2 predicted gene, 30083, transcript variant 2 (from RefSeq NM_001374166.1) A0A2I3BPJ2 A0A2I3BPJ2_MOUSE ENSMUST00000227795.1 Gm30083 NM_001374166 uc288sim.1 uc288sim.2 Belongs to the ATR family. transmembrane signaling receptor activity plasma membrane cell surface membrane integral component of membrane signaling receptor activity toxin transport uc288sim.1 uc288sim.2 
ENSMUST00000227799.2 Gm49266 ENSMUST00000227799.2 Gm49266 (from geneSymbol) AK148658 ENSMUST00000227799.1 uc288xhc.1 uc288xhc.2 uc288xhc.1 uc288xhc.2 
ENSMUST00000227803.2 Rubie ENSMUST00000227803.2 Rubie (from geneSymbol) ENSMUST00000227803.1 KY467695 uc288tbo.1 uc288tbo.2 uc288tbo.1 uc288tbo.2 
ENSMUST00000227805.2 Vmn1r28 ENSMUST00000227805.2 vomeronasal 1 receptor 28 (from RefSeq NM_134180.2) ENSMUST00000227805.1 NM_134180 Q8R2C9 Q8R2C9_MOUSE V1rc25 Vmn1r28 uc012emp.1 uc012emp.2 uc012emp.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc012emp.1 uc012emp.2 uc012emp.3 
ENSMUST00000227806.2 Gm56450 ENSMUST00000227806.2 Gm56450 (from geneSymbol) A0A2I3BRA8 A0A2I3BRA8_MOUSE BC058174 ENSMUST00000227806.1 Gm56450 uc290avr.1 uc290avr.2 membrane integral component of membrane uc290avr.1 uc290avr.2 
ENSMUST00000227813.2 Gm49161 ENSMUST00000227813.2 Gm49161 (from geneSymbol) ENSMUST00000227813.1 LF200190 uc288xdr.1 uc288xdr.2 uc288xdr.1 uc288xdr.2 
ENSMUST00000227835.2 Gm10791 ENSMUST00000227835.2 predicted gene 10791 (from RefSeq NR_045889.1) ENSMUST00000227835.1 NR_045889 uc007ztr.1 uc007ztr.2 uc007ztr.3 uc007ztr.4 uc007ztr.1 uc007ztr.2 uc007ztr.3 uc007ztr.4 
ENSMUST00000227840.3 Gm31072 ENSMUST00000227840.3 Gm31072 (from geneSymbol) ENSMUST00000227840.1 ENSMUST00000227840.2 uc288wkx.1 uc288wkx.2 uc288wkx.3 uc288wkx.1 uc288wkx.2 uc288wkx.3 
ENSMUST00000227843.2 Nudcd1 ENSMUST00000227843.2 NudC domain containing 1, transcript variant 1 (from RefSeq NM_026149.4) ENSMUST00000227843.1 NM_026149 NUDC1_MOUSE Nudcd1 Q3THV3 Q6PIP5 Q71EC1 Q8BJZ5 uc007vpq.1 uc007vpq.2 uc007vpq.3 uc007vpq.4 Cytoplasm Nucleus molecular_function nucleus nucleoplasm cytoplasm cytosol biological_process uc007vpq.1 uc007vpq.2 uc007vpq.3 uc007vpq.4 
ENSMUST00000227846.2 Vmn1r199 ENSMUST00000227846.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BQB1) A0A2I3BQB1 A0A2I3BQB1_MOUSE ENSMUST00000227846.1 Vmn1r199 uc288lif.1 uc288lif.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lif.1 uc288lif.2 
ENSMUST00000227861.2 Gm10389 ENSMUST00000227861.2 predicted gene 10389 (from RefSeq NR_033541.1) ENSMUST00000227861.1 NR_033541 uc011zri.1 uc011zri.2 uc011zri.1 uc011zri.2 
ENSMUST00000227882.3 Gm5624 ENSMUST00000227882.3 Gm5624 (from geneSymbol) A0A2I3BR58 A0A2I3BR58_MOUSE ENSMUST00000227882.1 ENSMUST00000227882.2 Gm5624 uc288svp.1 uc288svp.2 uc288svp.3 uc288svp.1 uc288svp.2 uc288svp.3 
ENSMUST00000227884.2 Vmn1r14 ENSMUST00000227884.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt H3BJ46) ENSMUST00000227884.1 H3BJ46 H3BJ46_MOUSE Vmn1r14 uc291etz.1 uc291etz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291etz.1 uc291etz.2 
ENSMUST00000227889.2 Gm49154 ENSMUST00000227889.2 Gm49154 (from geneSymbol) AK044621 ENSMUST00000227889.1 uc288thy.1 uc288thy.2 uc288thy.1 uc288thy.2 
ENSMUST00000227896.2 Gm49284 ENSMUST00000227896.2 Gm49284 (from geneSymbol) AK034553 ENSMUST00000227896.1 uc288xkn.1 uc288xkn.2 uc288xkn.1 uc288xkn.2 
ENSMUST00000227898.3 4933431J24Rik ENSMUST00000227898.3 4933431J24Rik (from geneSymbol) AK017006 ENSMUST00000227898.1 ENSMUST00000227898.2 uc007uys.1 uc007uys.2 uc007uys.3 uc007uys.4 uc007uys.1 uc007uys.2 uc007uys.3 uc007uys.4 
ENSMUST00000227908.2 Gm34759 ENSMUST00000227908.2 Gm34759 (from geneSymbol) ENSMUST00000227908.1 uc288xaj.1 uc288xaj.2 uc288xaj.1 uc288xaj.2 
ENSMUST00000227909.2 Vmn1r20 ENSMUST00000227909.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N778) ENSMUST00000227909.1 K7N778 K7N778_MOUSE Vmn1r20 uc291euj.1 uc291euj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291euj.1 uc291euj.2 
ENSMUST00000227918.3 Gm49227 ENSMUST00000227918.3 Gm49227 (from geneSymbol) ENSMUST00000227918.1 ENSMUST00000227918.2 uc289fte.1 uc289fte.2 uc289fte.3 uc289fte.1 uc289fte.2 uc289fte.3 
ENSMUST00000227931.2 Gm49097 ENSMUST00000227931.2 Gm49097 (from geneSymbol) AK134270 ENSMUST00000227931.1 uc007vnw.1 uc007vnw.2 uc007vnw.1 uc007vnw.2 
ENSMUST00000227953.3 Gm30556 ENSMUST00000227953.3 Gm30556 (from geneSymbol) ENSMUST00000227953.1 ENSMUST00000227953.2 uc288siw.1 uc288siw.2 uc288siw.3 uc288siw.1 uc288siw.2 uc288siw.3 
ENSMUST00000227959.3 Gm8417 ENSMUST00000227959.3 predicted gene 8417 (from RefSeq NR_164329.1) ENSMUST00000227959.1 ENSMUST00000227959.2 NR_164329 uc288tjx.1 uc288tjx.2 uc288tjx.3 uc288tjx.1 uc288tjx.2 uc288tjx.3 
ENSMUST00000227970.2 Gm30467 ENSMUST00000227970.2 Gm30467 (from geneSymbol) ENSMUST00000227970.1 uc288vuu.1 uc288vuu.2 uc288vuu.1 uc288vuu.2 
ENSMUST00000227974.2 Gm49035 ENSMUST00000227974.2 Gm49035 (from geneSymbol) AK029385 ENSMUST00000227974.1 uc288wog.1 uc288wog.2 uc288wog.1 uc288wog.2 
ENSMUST00000227975.3 Gm41279 ENSMUST00000227975.3 predicted gene, 41279 (from RefSeq NR_155439.1) ENSMUST00000227975.1 ENSMUST00000227975.2 NR_155439 uc288xgu.1 uc288xgu.2 uc288xgu.3 uc288xgu.1 uc288xgu.2 uc288xgu.3 
ENSMUST00000227980.2 Gm48912 ENSMUST00000227980.2 Gm48912 (from geneSymbol) ENSMUST00000227980.1 uc288tbk.1 uc288tbk.2 uc288tbk.1 uc288tbk.2 
ENSMUST00000227987.2 Vmn1r173 ENSMUST00000227987.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q8V7) E9Q8V7 E9Q8V7_MOUSE ENSMUST00000227987.1 Vmn1r173 uc291mrn.1 uc291mrn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291mrn.1 uc291mrn.2 
ENSMUST00000227993.2 Vmn1r178 ENSMUST00000227993.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2B6) D3Z247 ENSMUST00000227993.1 Q8R2B6 Q8R2B6_MOUSE V1rd13 Vmn1r168 Vmn1r178 uc291msd.1 uc291msd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291msd.1 uc291msd.2 
ENSMUST00000228002.2 Tmem184b ENSMUST00000228002.2 transmembrane protein 184b, transcript variant 5 (from RefSeq NM_001378998.1) A0A2I3BQI5 A0A2I3BQI5_MOUSE ENSMUST00000228002.1 NM_001378998 Tmem184b uc007wtj.1 uc007wtj.2 uc007wtj.3 Membrane ; Multi- pass membrane protein membrane integral component of membrane uc007wtj.1 uc007wtj.2 uc007wtj.3 
ENSMUST00000228011.2 9530086P17Rik ENSMUST00000228011.2 9530086P17Rik (from geneSymbol) AK020658 ENSMUST00000228011.1 uc288tgf.1 uc288tgf.2 uc288tgf.1 uc288tgf.2 
ENSMUST00000228020.2 Vmn1r202 ENSMUST00000228020.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R259) ENSMUST00000228020.1 Q8R259 Q8R259_MOUSE V1ri7 Vmn1r202 uc288lit.1 uc288lit.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lit.1 uc288lit.2 
ENSMUST00000228031.2 Vmn1r213 ENSMUST00000228031.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BPD2) A0A2I3BPD2 A0A2I3BPD2_MOUSE ENSMUST00000228031.1 Vmn1r213 uc288lkb.1 uc288lkb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lkb.1 uc288lkb.2 
ENSMUST00000228036.2 D130009I18Rik ENSMUST00000228036.2 RIKEN cDNA D130009I18 gene (from RefSeq NR_015593.3) ENSMUST00000228036.1 NR_015593 uc007uxg.1 uc007uxg.2 uc007uxg.3 uc007uxg.4 uc007uxg.1 uc007uxg.2 uc007uxg.3 uc007uxg.4 
ENSMUST00000228052.2 Ndor1 ENSMUST00000228052.2 NADPH dependent diflavin oxidoreductase 1, transcript variant 3 (from RefSeq NM_001252542.1) A0A2I3BQN1 A0A2I3BQN1_MOUSE ENSMUST00000228052.1 NM_001252542 Ndor1 uc008iqx.1 uc008iqx.2 uc008iqx.3 uc008iqx.4 Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; NADPH-hemoprotein reductase activity cytosol FMN binding membrane integral component of membrane oxidoreductase activity flavin adenine dinucleotide binding oxidation-reduction process uc008iqx.1 uc008iqx.2 uc008iqx.3 uc008iqx.4 
ENSMUST00000228062.2 Vmn1r57 ENSMUST00000228062.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N731) ENSMUST00000228062.1 K7N731 K7N731_MOUSE Vmn1r57 uc291kzc.1 uc291kzc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291kzc.1 uc291kzc.2 
ENSMUST00000228063.2 Gm49296 ENSMUST00000228063.2 Gm49296 (from geneSymbol) AK132921 ENSMUST00000228063.1 uc288xjr.1 uc288xjr.2 uc288xjr.1 uc288xjr.2 
ENSMUST00000228064.2 Ear14 ENSMUST00000228064.2 eosinophil-associated, ribonuclease A family, member 14 (from RefSeq NM_017389.2) ENSMUST00000228064.1 Ear14 NM_017389 Q5GAN2 Q5GAN2_MOUSE uc007tmv.1 uc007tmv.2 uc007tmv.3 uc007tmv.4 Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity ribonuclease activity cellular_component hydrolase activity nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis uc007tmv.1 uc007tmv.2 uc007tmv.3 uc007tmv.4 
ENSMUST00000228068.2 Vmn1r41 ENSMUST00000228068.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A0N4SVQ3) A0A0N4SVQ3 A0A0N4SVQ3_MOUSE ENSMUST00000228068.1 Vmn1r41 uc291gxy.1 uc291gxy.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291gxy.1 uc291gxy.2 
ENSMUST00000228070.2 Vmn1r26 ENSMUST00000228070.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2D7) ENSMUST00000228070.1 Q8R2D7 Q8R2D7_MOUSE V1rc17 Vmn1r26 uc291evt.1 uc291evt.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291evt.1 uc291evt.2 
ENSMUST00000228075.3 Zfp870 ENSMUST00000228075.3 zinc finger protein 870, transcript variant 2 (from RefSeq NM_207245.3) BC066107 ENSMUST00000228075.1 ENSMUST00000228075.2 NM_207245 Q6NZJ3 Q6NZJ3_MOUSE Zfp870 uc008bxp.1 uc008bxp.2 uc008bxp.3 uc008bxp.4 Nucleus nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc008bxp.1 uc008bxp.2 uc008bxp.3 uc008bxp.4 
ENSMUST00000228092.2 Vmn1r215 ENSMUST00000228092.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R264) ENSMUST00000228092.1 Q8R264 Q8R264_MOUSE V1ri2 Vmn1r215 uc007ptf.1 uc007ptf.2 uc007ptf.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc007ptf.1 uc007ptf.2 uc007ptf.3 
ENSMUST00000228095.2 D130079A08Rik ENSMUST00000228095.2 RIKEN cDNA D130079A08 gene (from RefSeq NR_168067.1) ENSMUST00000228095.1 NR_168067 uc007uxa.1 uc007uxa.2 uc007uxa.3 uc007uxa.1 uc007uxa.2 uc007uxa.3 
ENSMUST00000228097.2 Vmn1r24 ENSMUST00000228097.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2D6) ENSMUST00000228097.1 Q8R2D6 Q8R2D6_MOUSE V1rc18 Vmn1r24 uc291evo.1 uc291evo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291evo.1 uc291evo.2 
ENSMUST00000228100.2 D730044K07Rik ENSMUST00000228100.2 D730044K07Rik (from geneSymbol) AK029389 ENSMUST00000228100.1 uc056yyi.1 uc056yyi.2 uc056yyi.1 uc056yyi.2 
ENSMUST00000228104.2 Gm49292 ENSMUST00000228104.2 Gm49292 (from geneSymbol) ENSMUST00000228104.1 uc288wgh.1 uc288wgh.2 uc288wgh.1 uc288wgh.2 
ENSMUST00000228152.2 Osr2 ENSMUST00000228152.2 odd-skipped related 2, transcript variant 1 (from RefSeq NM_001368665.1) ENSMUST00000228152.1 NM_001368665 OSR2_MOUSE Osr2 Q8BPV6 Q91V54 Q91ZD1 uc007vmb.1 uc007vmb.2 uc007vmb.3 May be involved in the development of the mandibular molar tooth germ at the bud stage. Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=OSR2A; IsoId=Q91ZD1-1; Sequence=Displayed; Name=2; Synonyms=OSR2B; IsoId=Q91ZD1-2; Sequence=VSP_017122; First detected at 9.25 dpc, specifically in the mesonephric vesicles. By 10.0 dpc expression is also observed in the rostro-lateral mandibular mesenchyme immediately adjacent to the maxillary processes. In the developing limb buds it is expressed in a unique mesenchymal domain and the onset of the expression follows a distinct dorsal to ventral developmental time sequence beginning in the forelimb and then in the hindlimb. It exhibits a dynamic expression pattern during craniofacial development, in the mandibular and maxillary processes as well as the developing palate. It is also expressed at sites of epithelial-mesenchymal interactions during tooth and kidney development. Decrease in expression of the Wnt signaling genes Dkk2, Sfrp1 and Sfrp2 and an increase in Lef1 and Tcf7 in the mandibular molar tooth mesenchyme at 13.5 dpc. Belongs to the Odd C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding urogenital system development metanephros development mesonephros development chondrocyte differentiation nucleic acid binding nucleus positive regulation of cell proliferation embryo development ending in birth or egg hatching positive regulation of gene expression cell differentiation positive regulation of bone mineralization osteoblast proliferation embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic skeletal limb joint morphogenesis middle ear morphogenesis odontogenesis embryonic digit morphogenesis sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metal ion binding embryonic skeletal system morphogenesis pronephros development positive regulation of epithelial cell proliferation palate development embryonic skeletal joint morphogenesis head development bone morphogenesis eyelid development in camera-type eye embryonic skeletal joint development positive regulation of gastrulation uc007vmb.1 uc007vmb.2 uc007vmb.3 
ENSMUST00000228155.2 Gm48967 ENSMUST00000228155.2 Gm48967 (from geneSymbol) ENSMUST00000228155.1 LF304208 uc288wbk.1 uc288wbk.2 uc288wbk.1 uc288wbk.2 
ENSMUST00000228165.2 4930538L07Rik ENSMUST00000228165.2 4930538L07Rik (from geneSymbol) ENSMUST00000228165.1 uc288tfm.1 uc288tfm.2 uc288tfm.1 uc288tfm.2 
ENSMUST00000228169.2 4930431P03Rik ENSMUST00000228169.2 RIKEN cDNA 4930431P03 gene (from RefSeq NR_045059.1) ENSMUST00000228169.1 NR_045059 uc007tgb.1 uc007tgb.2 uc007tgb.3 uc007tgb.4 uc007tgb.1 uc007tgb.2 uc007tgb.3 uc007tgb.4 
ENSMUST00000228170.2 Gm48998 ENSMUST00000228170.2 Gm48998 (from geneSymbol) ENSMUST00000228170.1 LF200098 uc288vvn.1 uc288vvn.2 uc288vvn.1 uc288vvn.2 
ENSMUST00000228171.2 4930435M08Rik ENSMUST00000228171.2 4930435M08Rik (from geneSymbol) AK015326 ENSMUST00000228171.1 uc288wll.1 uc288wll.2 uc288wll.1 uc288wll.2 
ENSMUST00000228182.2 Gm41290 ENSMUST00000228182.2 Gm41290 (from geneSymbol) ENSMUST00000228182.1 uc288xlj.1 uc288xlj.2 uc288xlj.1 uc288xlj.2 
ENSMUST00000228195.2 Vmn1r204 ENSMUST00000228195.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt I7HIK1) ENSMUST00000228195.1 I7HIK1 I7HIK1_MOUSE Vmn1r204 uc288lix.1 uc288lix.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lix.1 uc288lix.2 
ENSMUST00000228200.2 Gm49189 ENSMUST00000228200.2 Gm49189 (from geneSymbol) ENSMUST00000228200.1 uc288tdq.1 uc288tdq.2 uc288tdq.1 uc288tdq.2 
ENSMUST00000228202.3 Gm49212 ENSMUST00000228202.3 Gm49212 (from geneSymbol) ENSMUST00000228202.1 ENSMUST00000228202.2 uc288ycn.1 uc288ycn.2 uc288ycn.3 uc288ycn.1 uc288ycn.2 uc288ycn.3 
ENSMUST00000228205.2 Gm49267 ENSMUST00000228205.2 Gm49267 (from geneSymbol) ENSMUST00000228205.1 uc288xgw.1 uc288xgw.2 uc288xgw.1 uc288xgw.2 
ENSMUST00000228215.2 Gm35769 ENSMUST00000228215.2 predicted gene, 35769 (from RefSeq NR_188865.1) ENSMUST00000228215.1 NR_188865 uc288xfl.1 uc288xfl.2 uc288xfl.1 uc288xfl.2 
ENSMUST00000228216.2 Klf12 ENSMUST00000228216.2 Kruppel-like transcription factor 12, transcript variant 1 (from RefSeq NM_010636.4) Ap2rep ENSMUST00000228216.1 KLF12_MOUSE NM_010636 O35738 Q6NWV9 uc007uvh.1 uc007uvh.2 uc007uvh.3 uc007uvh.4 uc007uvh.5 Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. Nucleus. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF12, the motif is inactive. Belongs to the Sp1 C2H2-type zinc-finger protein family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter metal ion binding uc007uvh.1 uc007uvh.2 uc007uvh.3 uc007uvh.4 uc007uvh.5 
ENSMUST00000228217.2 Gm10845 ENSMUST00000228217.2 predicted gene 10845 (from RefSeq NR_033535.1) ENSMUST00000228217.1 NR_033535 uc007utl.1 uc007utl.2 uc007utl.3 uc007utl.1 uc007utl.2 uc007utl.3 
ENSMUST00000228223.2 Gm49207 ENSMUST00000228223.2 Gm49207 (from geneSymbol) ENSMUST00000228223.1 uc288wvq.1 uc288wvq.2 uc288wvq.1 uc288wvq.2 
ENSMUST00000228225.2 Gm49077 ENSMUST00000228225.2 Gm49077 (from geneSymbol) ENSMUST00000228225.1 LF200230 uc288xtj.1 uc288xtj.2 uc288xtj.1 uc288xtj.2 
ENSMUST00000228243.2 Vmn1r188 ENSMUST00000228243.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8K3N2) ENSMUST00000228243.1 Q8K3N2 Q8K3N2_MOUSE V1rh17 Vmn1r188 uc288lha.1 uc288lha.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lha.1 uc288lha.2 
ENSMUST00000228245.3 Gm41318 ENSMUST00000228245.3 Gm41318 (from geneSymbol) ENSMUST00000228245.1 ENSMUST00000228245.2 uc288xzh.1 uc288xzh.2 uc288xzh.3 uc288xzh.1 uc288xzh.2 uc288xzh.3 
ENSMUST00000228250.2 Gm41325 ENSMUST00000228250.2 Gm41325 (from geneSymbol) ENSMUST00000228250.1 uc288ybn.1 uc288ybn.2 uc288ybn.1 uc288ybn.2 
ENSMUST00000228257.2 Vmn1r22 ENSMUST00000228257.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2D1) ENSMUST00000228257.1 Q8R2D1 Q8R2D1_MOUSE V1rc23 Vmn1r22 uc291evl.1 uc291evl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291evl.1 uc291evl.2 
ENSMUST00000228270.2 Vmn1r10 ENSMUST00000228270.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt W4VSP8) ENSMUST00000228270.1 Vmn1r10 W4VSP8 W4VSP8_MOUSE uc291etn.1 uc291etn.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291etn.1 uc291etn.2 
ENSMUST00000228274.2 9930017N22Rik ENSMUST00000228274.2 9930017N22Rik (from geneSymbol) ENSMUST00000228274.1 uc057bfv.1 uc057bfv.2 uc057bfv.1 uc057bfv.2 
ENSMUST00000228276.2 Vmn1r5 ENSMUST00000228276.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt B2RQT2) B2RQT2 B2RQT2_MOUSE ENSMUST00000228276.1 V1rc19 Vmn1r5 uc291etb.1 uc291etb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291etb.1 uc291etb.2 
ENSMUST00000228278.2 Gm49262 ENSMUST00000228278.2 Gm49262 (from geneSymbol) ENSMUST00000228278.1 uc288xpo.1 uc288xpo.2 uc288xpo.1 uc288xpo.2 
ENSMUST00000228297.2 Vmn1r15 ENSMUST00000228297.2 vomeronasal 1 receptor 15 (from RefSeq NM_053236.2) ENSMUST00000228297.1 NM_053236 Q14C10 Q14C10_MOUSE V1rc6 Vmn1r15 uc009ccb.1 uc009ccb.2 uc009ccb.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc009ccb.1 uc009ccb.2 uc009ccb.3 
ENSMUST00000228303.2 Vmn1r193 ENSMUST00000228303.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R258) ENSMUST00000228303.1 Q8R258 Q8R258_MOUSE V1ri9 Vmn1r193 uc288lho.1 uc288lho.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lho.1 uc288lho.2 
ENSMUST00000228307.2 Cdh9 ENSMUST00000228307.2 cadherin 9 (from RefSeq NM_009869.2) Cdh9 ENSMUST00000228307.1 F8WHU6 F8WHU6_MOUSE NM_009869 uc011zro.1 uc011zro.2 uc011zro.3 uc011zro.4 Cadherins are calcium-dependent cell adhesion proteins. Cell membrane ingle-pass type I membrane protein Membrane ; Single-pass type I membrane protein calcium ion binding plasma membrane cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly membrane integral component of membrane cell-cell adhesion integral component of postsynaptic membrane integral component of presynaptic membrane synaptic membrane adhesion uc011zro.1 uc011zro.2 uc011zro.3 uc011zro.4 
ENSMUST00000228313.2 Gm49247 ENSMUST00000228313.2 Gm49247 (from geneSymbol) ENSMUST00000228313.1 uc288wwf.1 uc288wwf.2 uc288wwf.1 uc288wwf.2 
ENSMUST00000228314.3 ENSMUSG00000121711 ENSMUST00000228314.3 ENSMUSG00000121711 (from geneSymbol) ENSMUST00000228314.1 ENSMUST00000228314.2 uc288vzx.1 uc288vzx.2 uc288vzx.3 uc288vzx.1 uc288vzx.2 uc288vzx.3 
ENSMUST00000228323.3 Gm49120 ENSMUST00000228323.3 Gm49120 (from geneSymbol) ENSMUST00000228323.1 ENSMUST00000228323.2 uc288thg.1 uc288thg.2 uc288thg.3 uc288thg.1 uc288thg.2 uc288thg.3 
ENSMUST00000228328.2 Nek4 ENSMUST00000228328.2 NIMA (never in mitosis gene a)-related expressed kinase 4, transcript variant 1 (from RefSeq NM_011849.3) ENSMUST00000228328.1 NM_011849 Nek4 Q6GTE9 Q6GTE9_MOUSE uc007swc.1 uc007swc.2 uc007swc.3 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. mitotic cell cycle protein kinase activity ATP binding cytosol protein phosphorylation cellular response to DNA damage stimulus kinase activity phosphorylation ciliary rootlet ciliary transition zone ciliary basal body positive regulation of transcription, DNA-templated ciliary plasm regulation of replicative cell aging regulation of cellular senescence regulation of response to DNA damage stimulus uc007swc.1 uc007swc.2 uc007swc.3 
ENSMUST00000228331.2 Vmn1r174 ENSMUST00000228331.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PYW5) E9PYW5 E9PYW5_MOUSE ENSMUST00000228331.1 Vmn1r174 uc291mro.1 uc291mro.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291mro.1 uc291mro.2 
ENSMUST00000228332.3 9630009A06Rik ENSMUST00000228332.3 9630009A06Rik (from geneSymbol) AK020673 ENSMUST00000228332.1 ENSMUST00000228332.2 uc288xji.1 uc288xji.2 uc288xji.3 uc288xji.1 uc288xji.2 uc288xji.3 
ENSMUST00000228336.2 Gm10926 ENSMUST00000228336.2 Gm10926 (from geneSymbol) AK156176 ENSMUST00000228336.1 uc288yjt.1 uc288yjt.2 uc288yjt.1 uc288yjt.2 
ENSMUST00000228339.4 Gm41335 ENSMUST00000228339.4 Gm41335 (from geneSymbol) AK040104 ENSMUST00000228339.1 ENSMUST00000228339.2 ENSMUST00000228339.3 uc288yhy.1 uc288yhy.2 uc288yhy.3 uc288yhy.1 uc288yhy.2 uc288yhy.3 
ENSMUST00000228342.2 Vmn1r17 ENSMUST00000228342.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2D8) ENSMUST00000228342.1 Q8R2D8 Q8R2D8_MOUSE V1rc16 Vmn1r17 uc291euh.1 uc291euh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291euh.1 uc291euh.2 
ENSMUST00000228343.2 Gm6740 ENSMUST00000228343.2 Gm6740 (from geneSymbol) ENSMUST00000228343.1 LF199944 uc288txb.1 uc288txb.2 uc288txb.1 uc288txb.2 
ENSMUST00000228344.3 4930597G03Rik ENSMUST00000228344.3 4930597G03Rik (from geneSymbol) AK016405 ENSMUST00000228344.1 ENSMUST00000228344.2 uc029sjb.1 uc029sjb.2 uc029sjb.3 uc029sjb.1 uc029sjb.2 uc029sjb.3 
ENSMUST00000228352.2 A530076I17Rik ENSMUST00000228352.2 A530076I17Rik (from geneSymbol) ENSMUST00000228352.1 uc288tao.1 uc288tao.2 uc288tao.1 uc288tao.2 
ENSMUST00000228355.2 2810457G06Rik ENSMUST00000228355.2 2810457G06Rik (from geneSymbol) ENSMUST00000228355.1 uc288tct.1 uc288tct.2 uc288tct.1 uc288tct.2 
ENSMUST00000228364.2 Gm2582 ENSMUST00000228364.2 predicted gene 2582 (from RefSeq NR_188840.1) ENSMUST00000228364.1 NR_188840 uc288ycu.1 uc288ycu.2 uc288ycu.1 uc288ycu.2 
ENSMUST00000228366.3 Nrbp2 ENSMUST00000228366.3 nuclear receptor binding protein 2 (from RefSeq NM_001358359.1) ENSMUST00000228366.1 ENSMUST00000228366.2 NM_001358359 NRBP2_MOUSE Nrbp2 Q8R3M0 Q91V36 uc288yxa.1 uc288yxa.2 May regulate apoptosis of neural progenitor cells during their differentiation. Cytoplasm Expressed in Purkinje cells of the cerebellum and neurons in the CA3 region of the hippocampus. Also detected in non- neural tissues including mesenchymal layer adjacent to epithelium in developing bronchi of the lung, the epithelium of the stomach as well as cells in the liver. Expressed in the cerebral cortex at 14 dpc (at protein level). Expressed in the walls of the third and fourth ventricles, and in the hippocampus during development. The protein kinase domain is predicted to be catalytically inactive. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Sequence=AAH11468.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=AAH12437.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function protein kinase activity protein serine/threonine kinase activity ATP binding cytoplasm protein phosphorylation ER to Golgi vesicle-mediated transport nervous system development endomembrane system neuron differentiation intracellular signal transduction negative regulation of neuron apoptotic process uc288yxa.1 uc288yxa.2 
ENSMUST00000228369.2 Vmn1r184 ENSMUST00000228369.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q2N4) E9Q2N4 E9Q2N4_MOUSE ENSMUST00000228369.1 Vmn1r184 uc291ncb.1 uc291ncb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291ncb.1 uc291ncb.2 
ENSMUST00000228376.2 Gm7968 ENSMUST00000228376.2 Gm7968 (from geneSymbol) ENSMUST00000228376.1 uc288xnq.1 uc288xnq.2 uc288xnq.1 uc288xnq.2 
ENSMUST00000228377.3 AA536875 ENSMUST00000228377.3 AA536875 (from geneSymbol) AK148280 ENSMUST00000228377.1 ENSMUST00000228377.2 uc288wqo.1 uc288wqo.2 uc288wqo.1 uc288wqo.2 
ENSMUST00000228383.2 Vmn1r175 ENSMUST00000228383.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N6T9) ENSMUST00000228383.1 K7N6T9 K7N6T9_MOUSE Vmn1r175 uc291mrs.1 uc291mrs.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291mrs.1 uc291mrs.2 
ENSMUST00000228384.2 Gm21154 ENSMUST00000228384.2 Gm21154 (from geneSymbol) ENSMUST00000228384.1 uc288ssf.1 uc288ssf.2 uc288ssf.1 uc288ssf.2 
ENSMUST00000228387.2 Gm48964 ENSMUST00000228387.2 Gm48964 (from geneSymbol) ENSMUST00000228387.1 uc288wbj.1 uc288wbj.2 uc288wbj.1 uc288wbj.2 
ENSMUST00000228389.2 Vmn1r216 ENSMUST00000228389.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R257) ENSMUST00000228389.1 Q8R257 Q8R257_MOUSE V1ri10 Vmn1r216 uc007ptg.1 uc007ptg.2 uc007ptg.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc007ptg.1 uc007ptg.2 uc007ptg.3 
ENSMUST00000228390.2 ENSMUSG00000121664 ENSMUST00000228390.2 ENSMUSG00000121664 (from geneSymbol) BC053505 ENSMUST00000228390.1 uc288xha.1 uc288xha.2 uc288xha.1 uc288xha.2 
ENSMUST00000228391.2 Gm49246 ENSMUST00000228391.2 Gm49246 (from geneSymbol) ENSMUST00000228391.1 uc057bfx.1 uc057bfx.2 uc057bfx.1 uc057bfx.2 
ENSMUST00000228395.2 Tssk4 ENSMUST00000228395.2 testis-specific serine kinase 4, transcript variant 3 (from RefSeq NM_001253888.1) A3QQQ9 A3QQR0 A3QQR1 A9P6P7 A9P6P9 ENSMUST00000228395.1 NM_001253888 Q9D411 Q9DA58 TSSK4_MOUSE Tssk4 Tssk5 uc007tzz.1 uc007tzz.2 uc007tzz.3 [Isoform 1]: Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (PubMed:17927909, PubMed:23599433, PubMed:23054012, PubMed:25361759, PubMed:26940607). May be involved in the Cre/Creb signaling pathway (PubMed:26940607). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (By similarity). Phosphorylates CREM on 'Ser-116' in vitro (PubMed:26940607). Phosphorylates ODF2 on 'Ser-95' (PubMed:26961893). [Isoform 2]: Catalytically inactive. [Isoform 3]: Catalytically inactive. [Isoform 4]: Catalytically inactive. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Mg(2+) and Mn(2+) were both present in the kinase buffer but Mg(2+) is likely to be the in vivo cofactor. ; Activated by autophosphorylation on Thr-197. Homodimer (PubMed:17927909, PubMed:23054012). Interacts with HSP90; this interaction stabilizes and activates TSSK4 (PubMed:23599433). Interacts with ODF2 (via C-terminus); this interaction promotes ODF2 phosphorylation on 'Ser-95' (PubMed:25361759, PubMed:26961893). May interact with CREM (PubMed:26940607). Interacts with CREB1; this interaction facilitates CREB1 phosphorylation on 'Ser- 133' (By similarity). Interacts with QRICH2 (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome Cell projection, cilium, flagellum te=In spermatozoa, present in the sperm head and in the flagellum. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Alpha ; IsoId=Q9D411-1; Sequence=Displayed; Name=2; Synonyms=b , Beta ; IsoId=Q9D411-2; Sequence=VSP_023561; Name=3; Synonyms=c , Gamma ; IsoId=Q9D411-3; Sequence=VSP_023561, VSP_059881, VSP_059884; Name=4; Synonyms=Delta ; IsoId=Q9D411-4; Sequence=VSP_023561, VSP_059882, VSP_059883; [Isoform 1]: Expressed in spermatocytes and mature sperm (at protein level) (PubMed:20729278, PubMed:23054012, PubMed:25361759, PubMed:26940607). Highly expressed in the spleen, heart and testis (PubMed:17927909, PubMed:20729278, PubMed:23054012). Isoform 2, isoform 3, and isoform 4: Expressed at highest level in testis and heart and at low levels in the liver, spleen, kidney, brain and thymus (PubMed:17927909). Detected throughout spermiogenesis, in round spermatids, elongated spermatids, and mature spermatozoa (PubMed:23054012, PubMed:20729278, PubMed:26940607). Detected at low levels on postnatal day 14, with significantly increased expression on postnatal day 16. Expression levels are unchanged after postnatal day 16 (PubMed:17927909, PubMed:20729278). Activated by autophosphorylation on Thr-197. ODF2 potentiates the autophosphorylation activity of TSSK4 at Thr-197. Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation. Male mice are subfertile due to reduced sperm motility. The reduced motility is due to morphological defects in the sperm flagellum at the midpiece-principal piece junction caused by the disordered arrangement of doublet microtubules and outer dense fibers. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Sequence=BAB24429.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence=; nucleotide binding magnesium ion binding acrosomal vesicle protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm cilium protein phosphorylation multicellular organism development spermatogenesis spermatid development fertilization kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation cell differentiation cytoplasmic vesicle motile cilium positive regulation of CREB transcription factor activity intracellular signal transduction sperm flagellum protein homodimerization activity cell projection macromolecular complex binding metal ion binding sperm motility peptidyl-threonine autophosphorylation uc007tzz.1 uc007tzz.2 uc007tzz.3 
ENSMUST00000228396.2 Gm48950 ENSMUST00000228396.2 Gm48950 (from geneSymbol) AK051133 ENSMUST00000228396.1 uc288tju.1 uc288tju.2 uc288tju.1 uc288tju.2 
ENSMUST00000228398.2 Gm49020 ENSMUST00000228398.2 Gm49020 (from geneSymbol) AK157039 ENSMUST00000228398.1 uc288ukt.1 uc288ukt.2 uc288ukt.1 uc288ukt.2 
ENSMUST00000228401.2 Vmn1r46 ENSMUST00000228401.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (from UniProt Q9EQ45) ENSMUST00000228401.1 Q9EQ45 V1R46_MOUSE V1ra13 V1rb8 uc291gzd.1 uc291gzd.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Cell membrane ; Multi-pass membrane protein Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291gzd.1 uc291gzd.2 
ENSMUST00000228406.2 Gm20555 ENSMUST00000228406.2 Gm20555 (from geneSymbol) AK085085 ENSMUST00000228406.1 uc288xie.1 uc288xie.2 uc288xie.1 uc288xie.2 
ENSMUST00000228409.2 Gm5089 ENSMUST00000228409.2 Gm5089 (from geneSymbol) AK047660 ENSMUST00000228409.1 uc007vaz.1 uc007vaz.2 uc007vaz.3 uc007vaz.4 uc007vaz.1 uc007vaz.2 uc007vaz.3 uc007vaz.4 
ENSMUST00000228411.2 1100001I12Rik ENSMUST00000228411.2 1100001I12Rik (from geneSymbol) AK003173 ENSMUST00000228411.1 uc288xtn.1 uc288xtn.2 uc288xtn.1 uc288xtn.2 
ENSMUST00000228418.2 Gm19276 ENSMUST00000228418.2 Gm19276 (from geneSymbol) AK078846 ENSMUST00000228418.1 uc288wzh.1 uc288wzh.2 uc288wzh.1 uc288wzh.2 
ENSMUST00000228424.2 Gm48949 ENSMUST00000228424.2 Gm48949 (from geneSymbol) ENSMUST00000228424.1 uc288tcn.1 uc288tcn.2 uc288tcn.1 uc288tcn.2 
ENSMUST00000228428.2 Vmn1r189 ENSMUST00000228428.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8K3N3) ENSMUST00000228428.1 Q8K3N3 Q8K3N3_MOUSE V1rh2 Vmn1r189 uc288lhc.1 uc288lhc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lhc.1 uc288lhc.2 
ENSMUST00000228432.2 Gm49310 ENSMUST00000228432.2 Gm49310 (from geneSymbol) AK052036 ENSMUST00000228432.1 uc288tgg.1 uc288tgg.2 uc288tgg.1 uc288tgg.2 
ENSMUST00000228438.2 Gm49729 ENSMUST00000228438.2 Gm49729 (from geneSymbol) AK019728 ENSMUST00000228438.1 uc288xfe.1 uc288xfe.2 uc288xfe.1 uc288xfe.2 
ENSMUST00000228441.2 Gm49180 ENSMUST00000228441.2 Gm49180 (from geneSymbol) ENSMUST00000228441.1 uc288sxm.1 uc288sxm.2 uc288sxm.1 uc288sxm.2 
ENSMUST00000228461.2 Gm49272 ENSMUST00000228461.2 Gm49272 (from geneSymbol) ENSMUST00000228461.1 uc289byf.1 uc289byf.2 uc289byf.1 uc289byf.2 
ENSMUST00000228463.2 Vmn1r75 ENSMUST00000228463.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R289) ENSMUST00000228463.1 Q8R289 Q8R289_MOUSE V1rg6 Vmn1r75 uc291lmg.1 uc291lmg.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lmg.1 uc291lmg.2 
ENSMUST00000228464.2 Gm49254 ENSMUST00000228464.2 Gm49254 (from geneSymbol) AK090010 ENSMUST00000228464.1 uc288xvd.1 uc288xvd.2 uc288xvd.1 uc288xvd.2 
ENSMUST00000228471.2 Vmn1r74 ENSMUST00000228471.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R290) ENSMUST00000228471.1 Q8R290 Q8R290_MOUSE V1rg5 Vmn1r74 uc291lly.1 uc291lly.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lly.1 uc291lly.2 
ENSMUST00000228495.3 Slc22a17 ENSMUST00000228495.3 Membrane ; Multi- pass membrane protein (from UniProt A0A2I3BQG7) A0A2I3BQG7 A0A2I3BQG7_MOUSE AK163116 ENSMUST00000228495.1 ENSMUST00000228495.2 Slc22a17 uc288ujb.1 uc288ujb.2 Membrane ; Multi- pass membrane protein membrane integral component of membrane transmembrane transporter activity transmembrane transport uc288ujb.1 uc288ujb.2 
ENSMUST00000228499.2 4930570B17Rik ENSMUST00000228499.2 4930570B17Rik (from geneSymbol) AK016261 ENSMUST00000228499.1 uc288xje.1 uc288xje.2 uc288xje.1 uc288xje.2 
ENSMUST00000228502.2 Gm49151 ENSMUST00000228502.2 Gm49151 (from geneSymbol) ENSMUST00000228502.1 uc288thj.1 uc288thj.2 uc288thj.1 uc288thj.2 
ENSMUST00000228505.3 Gm9732 ENSMUST00000228505.3 predicted gene 9732 (from RefSeq NR_154584.1) ENSMUST00000228505.1 ENSMUST00000228505.2 NR_154584 uc007tcy.1 uc007tcy.2 uc007tcy.3 uc007tcy.4 uc007tcy.1 uc007tcy.2 uc007tcy.3 uc007tcy.4 
ENSMUST00000228508.2 Gm49314 ENSMUST00000228508.2 Gm49314 (from geneSymbol) ENSMUST00000228508.1 uc288xst.1 uc288xst.2 uc288xst.1 uc288xst.2 
ENSMUST00000228526.2 Vmn1r71 ENSMUST00000228526.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VIC0) ENSMUST00000228526.1 Q8VIC0 Q8VIC0_MOUSE V1RE7 V1re1 V1re13 Vmn1r71 uc291ljj.1 uc291ljj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291ljj.1 uc291ljj.2 
ENSMUST00000228529.2 Ogdhl ENSMUST00000228529.2 oxoglutarate dehydrogenase-like (from RefSeq NM_001081130.2) B2RXT3 B2RXT3_MOUSE ENSMUST00000228529.1 NM_001081130 Ogdhl uc011zik.1 uc011zik.2 uc011zik.3 Reaction=2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl- [dihydrolipoyllysine-residue succinyltransferase] = CO2 + N(6)-[(R)- S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]; Xref=Rhea:RHEA:12188, Rhea:RHEA-COMP:10483, Rhea:RHEA-COMP:10484, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:83099, ChEBI:CHEBI:83120; EC=1.2.4.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12189; Evidence=; Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Belongs to the alpha-ketoglutarate dehydrogenase family. oxoglutarate dehydrogenase (succinyl-transferring) activity mitochondrion tricarboxylic acid cycle oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor thiamine pyrophosphate binding oxoglutarate dehydrogenase complex oxidation-reduction process uc011zik.1 uc011zik.2 uc011zik.3 
ENSMUST00000228530.2 Vmn1r27 ENSMUST00000228530.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N688) ENSMUST00000228530.1 K7N688 K7N688_MOUSE Vmn1r27 uc291ewd.1 uc291ewd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291ewd.1 uc291ewd.2 
ENSMUST00000228533.2 Gm49319 ENSMUST00000228533.2 Gm49319 (from geneSymbol) ENSMUST00000228533.1 uc288tbl.1 uc288tbl.2 uc288tbl.1 uc288tbl.2 
ENSMUST00000228534.2 Gm49786 ENSMUST00000228534.2 Gm49786 (from geneSymbol) BC038309 ENSMUST00000228534.1 uc288xub.1 uc288xub.2 uc288xub.1 uc288xub.2 
ENSMUST00000228538.3 Tatdn1 ENSMUST00000228538.3 TatD DNase domain containing 1, transcript variant 11 (from RefSeq NM_001368636.1) ENSMUST00000228538.1 ENSMUST00000228538.2 NM_001368636 Q6P8M1 Q8BY37 TATD1_MOUSE uc288yex.1 uc288yex.2 uc288yex.3 Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules (By similarity). Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity (By similarity). Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence=; Note=Binds 2 divalent metal cations per subunit. ; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P8M1-1; Sequence=Displayed; Name=2; IsoId=Q6P8M1-2; Sequence=VSP_030046, VSP_030047; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. nuclease activity nucleus nucleoplasm DNA metabolic process 3'-5'-exodeoxyribonuclease activity hydrolase activity hydrolase activity, acting on ester bonds endodeoxyribonuclease activity, producing 5'-phosphomonoesters metal ion binding nucleic acid phosphodiester bond hydrolysis uc288yex.1 uc288yex.2 uc288yex.3 
ENSMUST00000228539.3 Gm34060 ENSMUST00000228539.3 Gm34060 (from geneSymbol) ENSMUST00000228539.1 ENSMUST00000228539.2 uc288swi.1 uc288swi.2 uc288swi.3 uc288swi.1 uc288swi.2 uc288swi.3 
ENSMUST00000228551.2 Gm49257 ENSMUST00000228551.2 Gm49257 (from geneSymbol) ENSMUST00000228551.1 uc288yby.1 uc288yby.2 uc288yby.1 uc288yby.2 
ENSMUST00000228557.2 Vmn1r196 ENSMUST00000228557.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5SVD5) ENSMUST00000228557.1 Q5SVD5 Q5SVD5_MOUSE Vmn1r196 uc288lhu.1 uc288lhu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lhu.1 uc288lhu.2 
ENSMUST00000228568.2 Gm49004 ENSMUST00000228568.2 Gm49004 (from geneSymbol) ENSMUST00000228568.1 uc288ter.1 uc288ter.2 uc288ter.1 uc288ter.2 
ENSMUST00000228572.2 9630050E16Rik ENSMUST00000228572.2 9630050E16Rik (from geneSymbol) ENSMUST00000228572.1 LF270978 uc288szt.1 uc288szt.2 uc288szt.1 uc288szt.2 
ENSMUST00000228574.2 Vmn1r18 ENSMUST00000228574.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2C8) ENSMUST00000228574.1 Q8R2C8 Q8R2C8_MOUSE V1rc26 Vmn1r18 uc009cce.1 uc009cce.2 uc009cce.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc009cce.1 uc009cce.2 uc009cce.3 
ENSMUST00000228586.2 Vmn1r31 ENSMUST00000228586.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt H3BKW5) ENSMUST00000228586.1 H3BKW5 H3BKW5_MOUSE Vmn1r31 uc291ewx.1 uc291ewx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291ewx.1 uc291ewx.2 
ENSMUST00000228587.2 Vmn1r89 ENSMUST00000228587.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R256) ENSMUST00000228587.1 Q8R256 Q8R256_MOUSE V1rj2 Vmn1r89 uc291lsl.1 uc291lsl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lsl.1 uc291lsl.2 
ENSMUST00000228599.2 Gm4278 ENSMUST00000228599.2 predicted gene 4278 (from RefSeq NR_046078.1) ENSMUST00000228599.1 NR_046078 uc029slx.1 uc029slx.2 uc029slx.1 uc029slx.2 
ENSMUST00000228608.2 Gm49069 ENSMUST00000228608.2 Gm49069 (from geneSymbol) AK148833 ENSMUST00000228608.1 uc288wrg.1 uc288wrg.2 uc288wrg.1 uc288wrg.2 
ENSMUST00000228609.3 Gm32815 ENSMUST00000228609.3 predicted gene, 32815, transcript variant 1 (from RefSeq NR_166898.1) ENSMUST00000228609.1 ENSMUST00000228609.2 NR_166898 uc288vyt.1 uc288vyt.2 uc288vyt.3 uc288vyt.1 uc288vyt.2 uc288vyt.3 
ENSMUST00000228611.2 Gm49234 ENSMUST00000228611.2 Gm49234 (from geneSymbol) AK156471 ENSMUST00000228611.1 uc288xil.1 uc288xil.2 uc288xil.1 uc288xil.2 
ENSMUST00000228616.2 Gm48939 ENSMUST00000228616.2 Gm48939 (from geneSymbol) ENSMUST00000228616.1 LF199899 uc288tcc.1 uc288tcc.2 uc288tcc.1 uc288tcc.2 
ENSMUST00000228618.2 Gm36642 ENSMUST00000228618.2 Gm36642 (from geneSymbol) AK086666 ENSMUST00000228618.1 uc288xgb.1 uc288xgb.2 uc288xgb.1 uc288xgb.2 
ENSMUST00000228622.2 Vmn1r66 ENSMUST00000228622.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8K4I0) ENSMUST00000228622.1 Q8K4I0 Q8K4I0_MOUSE V1re11 V1re3 Vmn1r66 uc291lhw.1 uc291lhw.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lhw.1 uc291lhw.2 
ENSMUST00000228623.2 Gm49150 ENSMUST00000228623.2 Gm49150 (from geneSymbol) ENSMUST00000228623.1 uc288tdl.1 uc288tdl.2 uc288tdl.1 uc288tdl.2 
ENSMUST00000228627.3 Ndor1 ENSMUST00000228627.3 Ndor1 (from geneSymbol) A0A2I3BPW1 A0A2I3BPW1_MOUSE AK213139 ENSMUST00000228627.1 ENSMUST00000228627.2 Ndor1 uc289tuu.1 uc289tuu.2 membrane integral component of membrane uc289tuu.1 uc289tuu.2 
ENSMUST00000228635.2 Vmn1r30 ENSMUST00000228635.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2D2) ENSMUST00000228635.1 G3X9G3 Q8R2D2 Q8R2D2_MOUSE V1rc22 Vmn1r30 uc291ewo.1 uc291ewo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291ewo.1 uc291ewo.2 
ENSMUST00000228636.2 Gm49311 ENSMUST00000228636.2 Gm49311 (from geneSymbol) ENSMUST00000228636.1 uc288xrl.1 uc288xrl.2 uc288xrl.1 uc288xrl.2 
ENSMUST00000228642.2 Vmn1r40 ENSMUST00000228642.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (from UniProt Q9EQ46) ENSMUST00000228642.1 Q9EQ46 V1R40_MOUSE V1ra11 V1rb7 uc291gxt.1 uc291gxt.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Cell membrane ; Multi-pass membrane protein Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291gxt.1 uc291gxt.2 
ENSMUST00000228645.2 Vmn1r211 ENSMUST00000228645.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R266) ENSMUST00000228645.1 Q8R266 Q8R266_MOUSE V1rh20 Vmn1r211 uc007ptb.1 uc007ptb.2 uc007ptb.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc007ptb.1 uc007ptb.2 uc007ptb.3 
ENSMUST00000228650.2 G930009F23Rik ENSMUST00000228650.2 G930009F23Rik (from geneSymbol) AK145170 ENSMUST00000228650.1 uc288xtb.1 uc288xtb.2 uc288xtb.1 uc288xtb.2 
ENSMUST00000228652.2 Gm49685 ENSMUST00000228652.2 Gm49685 (from geneSymbol) AK084059 ENSMUST00000228652.1 uc007vin.1 uc007vin.2 uc007vin.1 uc007vin.2 
ENSMUST00000228653.2 Vmn1r84 ENSMUST00000228653.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BRH2) A0A2I3BRH2 A0A2I3BRH2_MOUSE ENSMUST00000228653.1 Vmn1r84 uc291lol.1 uc291lol.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lol.1 uc291lol.2 
ENSMUST00000228660.2 Gm34794 ENSMUST00000228660.2 Gm34794 (from geneSymbol) ENSMUST00000228660.1 uc288yaj.1 uc288yaj.2 uc288yaj.1 uc288yaj.2 
ENSMUST00000228662.2 Vmn1r45 ENSMUST00000228662.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (from UniProt Q8VIC7) ENSMUST00000228662.1 Pr2 Q8VIC7 Q9Z196 V1R45_MOUSE V1ra2 V1ra9 Y12724 uc291gyz.1 uc291gyz.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Cell membrane ; Multi-pass membrane protein Expressed in a subset of sensory neurons located in the apical layer of the vomeronasal organ. Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Belongs to the G-protein coupled receptor 1 family. Sequence=CAA73256.1; Type=Erroneous initiation; Evidence=; G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291gyz.1 uc291gyz.2 
ENSMUST00000228664.2 Vmn1r78 ENSMUST00000228664.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt K7N608) ENSMUST00000228664.1 K7N608 K7N608_MOUSE Vmn1r78 uc291lnj.1 uc291lnj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lnj.1 uc291lnj.2 
ENSMUST00000228665.2 Vmn1r52 ENSMUST00000228665.2 vomeronasal 1 receptor 52 (from RefSeq NM_053222.2) ENSMUST00000228665.1 NM_053222 Q9EP79 V1R52_MOUSE V1ra7 uc291hah.1 uc291hah.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Cell membrane ; Multi-pass membrane protein Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291hah.1 uc291hah.2 
ENSMUST00000228666.2 Vmn1r219 ENSMUST00000228666.2 Cell membrane ; Multi-pass membrane protein (from UniProt Q8R271) ENSMUST00000228666.1 Q8R271 Q8R271_MOUSE V1rh13 Vmn1r219 uc288lky.1 uc288lky.2 Cell membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lky.1 uc288lky.2 
ENSMUST00000228676.2 Vmn1r185 ENSMUST00000228676.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R299) ENSMUST00000228676.1 Q8R299 Q8R299_MOUSE V1re12 Vmn1r185 uc291ncv.1 uc291ncv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291ncv.1 uc291ncv.2 
ENSMUST00000228677.2 Gm48935 ENSMUST00000228677.2 Gm48935 (from geneSymbol) ENSMUST00000228677.1 uc288tjf.1 uc288tjf.2 uc288tjf.1 uc288tjf.2 
ENSMUST00000228680.2 Vmn1r47 ENSMUST00000228680.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A0R4J0Y0) A0A0R4J0Y0 A0A0R4J0Y0_MOUSE ENSMUST00000228680.1 Vmn1r47 uc291gzh.1 uc291gzh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291gzh.1 uc291gzh.2 
ENSMUST00000228681.2 Vmn1r171 ENSMUST00000228681.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A2I3BQT3) A0A2I3BQT3 A0A2I3BQT3_MOUSE ENSMUST00000228681.1 Vmn1r171 uc291mrl.1 uc291mrl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291mrl.1 uc291mrl.2 
ENSMUST00000228692.3 ENSMUSG00000121410 ENSMUST00000228692.3 ENSMUSG00000121410 (from geneSymbol) ENSMUST00000228692.1 ENSMUST00000228692.2 uc288svv.1 uc288svv.2 uc288svv.3 uc288svv.1 uc288svv.2 uc288svv.3 
ENSMUST00000228696.2 1700085D07Rik ENSMUST00000228696.2 1700085D07Rik (from geneSymbol) AK007005 ENSMUST00000228696.1 uc288ypc.1 uc288ypc.2 uc288ypc.1 uc288ypc.2 
ENSMUST00000228702.2 Gm30929 ENSMUST00000228702.2 Gm30929 (from geneSymbol) ENSMUST00000228702.1 uc288yky.1 uc288yky.2 uc288yky.1 uc288yky.2 
ENSMUST00000228705.2 Gm5088 ENSMUST00000228705.2 predicted gene 5088 (from RefSeq NR_002862.3) ENSMUST00000228705.1 NR_002862 uc288wao.1 uc288wao.2 uc288wao.1 uc288wao.2 
ENSMUST00000228706.2 Gm49162 ENSMUST00000228706.2 Gm49162 (from geneSymbol) ENSMUST00000228706.1 uc288xdq.1 uc288xdq.2 uc288xdq.1 uc288xdq.2 
ENSMUST00000228709.2 Vmn1r43 ENSMUST00000228709.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (from UniProt Q8VIC9) ENSMUST00000228709.1 Q05A91 Q8VIC9 Q9EQ50 V1R43_MOUSE V1ra2 V1ra5 uc291gyg.1 uc291gyg.2 Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Cell membrane ; Multi-pass membrane protein Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291gyg.1 uc291gyg.2 
ENSMUST00000228711.2 Vmn1r195 ENSMUST00000228711.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5SVD6) ENSMUST00000228711.1 Q5SVD6 Q5SVD6_MOUSE V1ri6 Vmn1r195 uc288lhp.1 uc288lhp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lhp.1 uc288lhp.2 
ENSMUST00000228714.2 Vmn1r9 ENSMUST00000228714.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2RST7) A2RST7 A2RST7_MOUSE ENSMUST00000228714.1 V1rc30 Vmn1r9 uc291etm.1 uc291etm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291etm.1 uc291etm.2 
ENSMUST00000228715.3 Mhrt ENSMUST00000228715.3 Mhrt (from geneSymbol) AK076663 ENSMUST00000228715.1 ENSMUST00000228715.2 uc288ujr.1 uc288ujr.2 uc288ujr.3 uc288ujr.1 uc288ujr.2 uc288ujr.3 
ENSMUST00000228716.3 Cryaa ENSMUST00000228716.3 crystallin, alpha A, transcript variant 3 (from RefSeq NM_001278570.1) Cryaa ENSMUST00000228716.1 ENSMUST00000228716.2 NM_001278570 Q569M7 Q569M7_MOUSE uc008bvq.1 uc008bvq.2 uc008bvq.3 uc008bvq.4 uc008bvq.5 This gene encodes subunit a, one of two subunits of alpha-crystallin, which is a high molecular weight, soluble aggregate and is a member of the small heat shock protein (sHSP) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. It acts as a molecular chaperone and is the major protein in the eye lens, maintaining the transparency and refractive index of the lens. In mouse, deficiency in this gene is associated with smaller lenses and eyes and with increasing lens opacity with age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Cytoplasm Nucleus Belongs to the small heat shock protein (HSP20) family. structural constituent of eye lens metal ion binding uc008bvq.1 uc008bvq.2 uc008bvq.3 uc008bvq.4 uc008bvq.5 
ENSMUST00000228721.2 Gm1587 ENSMUST00000228721.2 predicted gene 1587 (from RefSeq NR_157389.1) ENSMUST00000228721.1 NR_157389 uc007usb.1 uc007usb.2 uc007usb.3 uc007usb.1 uc007usb.2 uc007usb.3 
ENSMUST00000228726.2 Vmn1r200 ENSMUST00000228726.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R281) ENSMUST00000228726.1 Q8R281 Q8R281_MOUSE V1rh3 Vmn1r200 uc288lij.1 uc288lij.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lij.1 uc288lij.2 
ENSMUST00000228728.2 Vmn1r58 ENSMUST00000228728.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt G3X9U3) AF324869 ENSMUST00000228728.1 G3X9U3 G3X9U3_MOUSE Vmn1r58 uc033iwj.1 uc033iwj.2 uc033iwj.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc033iwj.1 uc033iwj.2 uc033iwj.3 
ENSMUST00000228734.2 Gm49132 ENSMUST00000228734.2 Gm49132 (from geneSymbol) DQ726971 ENSMUST00000228734.1 uc288tda.1 uc288tda.2 uc288tda.1 uc288tda.2 
ENSMUST00000228735.2 Gm48986 ENSMUST00000228735.2 Gm48986 (from geneSymbol) AK077956 ENSMUST00000228735.1 uc288tem.1 uc288tem.2 uc288tem.1 uc288tem.2 
ENSMUST00000228736.2 Spcs1 ENSMUST00000228736.2 signal peptidase complex subunit 1 homolog (S. cerevisiae) (from RefSeq NM_026911.4) A0A2I3BRW0 A0A2I3BRW0_MOUSE ENSMUST00000228736.1 NM_026911 Spcs1 uc288ryt.1 uc288ryt.2 Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the SPCS1 family. signal peptidase complex signal peptide processing peptidase activity membrane integral component of membrane uc288ryt.1 uc288ryt.2 
ENSMUST00000228742.2 Gm49149 ENSMUST00000228742.2 Gm49149 (from geneSymbol) AK047060 ENSMUST00000228742.1 uc288tdi.1 uc288tdi.2 uc288tdi.1 uc288tdi.2 
ENSMUST00000228749.2 Olfm4 ENSMUST00000228749.2 olfactomedin 4 (from RefSeq NM_001351947.1) ENSMUST00000228749.1 NM_001351947 OLFM4_MOUSE Q3UZZ4 uc007utn.1 uc007utn.2 uc007utn.3 May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin (By similarity). Homomultimer; disulfide-linked. Interacts with NDUFA13. Interacts with cell surface lectins (locutions ricinus communis agglutinin I, concanavalin A and wheat germ agglutinin) and cadherin (By similarity). Secreted, extracellular space Mitochondrion The olfactomedin-like domain is involved in the interaction with cadherin. N-glycosylated. protein binding extracellular region extracellular space mitochondrion plasma membrane cell adhesion specific granule protein homodimerization activity negative regulation of I-kappaB kinase/NF-kappaB signaling cadherin binding perinuclear region of cytoplasm negative regulation of immune response protein homooligomerization positive regulation of substrate adhesion-dependent cell spreading uc007utn.1 uc007utn.2 uc007utn.3 
ENSMUST00000228755.2 Gm35823 ENSMUST00000228755.2 Gm35823 (from geneSymbol) ENSMUST00000228755.1 uc288sci.1 uc288sci.2 uc288sci.1 uc288sci.2 
ENSMUST00000228762.2 Gm48984 ENSMUST00000228762.2 Gm48984 (from geneSymbol) ENSMUST00000228762.1 uc289gib.1 uc289gib.2 uc289gib.1 uc289gib.2 
ENSMUST00000228764.2 Vmn1r81 ENSMUST00000228764.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R286) ENSMUST00000228764.1 Q8R286 Q8R286_MOUSE V1rg9 Vmn1r81 uc291lod.1 uc291lod.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lod.1 uc291lod.2 
ENSMUST00000228765.2 Gm9891 ENSMUST00000228765.2 Gm9891 (from geneSymbol) ENSMUST00000228765.1 LF200198 uc288xid.1 uc288xid.2 uc288xid.1 uc288xid.2 
ENSMUST00000228770.3 4930432J09Rik ENSMUST00000228770.3 RIKEN cDNA 4930432J09 gene (from RefSeq NR_045953.1) ENSMUST00000228770.1 ENSMUST00000228770.2 NR_045953 uc029sms.1 uc029sms.2 uc029sms.3 uc029sms.1 uc029sms.2 uc029sms.3 
ENSMUST00000228780.2 9330182O14Rik ENSMUST00000228780.2 RIKEN cDNA 9330182O14 gene (from RefSeq NM_001256056.1) 9330182O14Rik ENSMUST00000228780.1 J3QNB2 J3QNB2_MOUSE NM_001256056 uc029sos.1 uc029sos.2 molecular_function cellular_component biological_process uc029sos.1 uc029sos.2 
ENSMUST00000228783.2 Atad2 ENSMUST00000228783.2 ATPase family, AAA domain containing 2, transcript variant 5 (from RefSeq NM_001404766.1) ATAD2_MOUSE ENSMUST00000228783.1 NM_001404766 Q3UYW6 Q8CDM1 uc288yds.1 uc288yds.2 May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation (By similarity). Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro) (By similarity). Q8CDM1; P62806: H4c1; NbExp=2; IntAct=EBI-2944582, EBI-299632; Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CDM1-1; Sequence=Displayed; Name=2; IsoId=Q8CDM1-2; Sequence=VSP_035804, VSP_035805, VSP_035806, VSP_035807; Belongs to the AAA ATPase family. nucleotide binding chromatin binding protein binding ATP binding nucleus nucleoplasm chromatin organization regulation of transcription, DNA-templated hydrolase activity ATPase activity negative regulation of chromatin silencing histone binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc288yds.1 uc288yds.2 
ENSMUST00000228787.2 Gm49356 ENSMUST00000228787.2 Gm49356 (from geneSymbol) A0A2I3BRG9 A0A2I3BRG9_MOUSE BC031539 ENSMUST00000228787.1 Gm49356 uc288yev.1 uc288yev.2 uc288yev.1 uc288yev.2 
ENSMUST00000228793.2 Vmn1r176 ENSMUST00000228793.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt G3UW31) E9Q118 ENSMUST00000228793.1 G3UW31 G3UW31_MOUSE G3UWG3 G5E8X9 Vmn1r170 Vmn1r176 uc291mry.1 uc291mry.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291mry.1 uc291mry.2 
ENSMUST00000228800.2 Vmn1r87 ENSMUST00000228800.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R255) ENSMUST00000228800.1 Q8R255 Q8R255_MOUSE V1rk1 Vmn1r87 uc291lsa.1 uc291lsa.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291lsa.1 uc291lsa.2 
ENSMUST00000228809.2 Gm48936 ENSMUST00000228809.2 Gm48936 (from geneSymbol) AK079710 ENSMUST00000228809.1 uc288tji.1 uc288tji.2 uc288tji.1 uc288tji.2 
ENSMUST00000228828.3 Gm41138 ENSMUST00000228828.3 Gm41138 (from geneSymbol) ENSMUST00000228828.1 ENSMUST00000228828.2 uc288stb.1 uc288stb.2 uc288stb.3 uc288stb.1 uc288stb.2 uc288stb.3 
ENSMUST00000228829.2 9130002K18Rik ENSMUST00000228829.2 9130002K18Rik (from geneSymbol) DQ701690 ENSMUST00000228829.1 uc288xns.1 uc288xns.2 uc288xns.1 uc288xns.2 
ENSMUST00000228830.2 Gm48961 ENSMUST00000228830.2 Gm48961 (from geneSymbol) AK132437 ENSMUST00000228830.1 uc288xnv.1 uc288xnv.2 uc288xnv.1 uc288xnv.2 
ENSMUST00000228832.2 Vmn1r169 ENSMUST00000228832.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt L7N275) ENSMUST00000228832.1 L7N275 L7N275_MOUSE Vmn1r169 uc291mqz.1 uc291mqz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291mqz.1 uc291mqz.2 
ENSMUST00000228835.2 Ang2 ENSMUST00000228835.2 angiogenin, ribonuclease A family, member 2 (from RefSeq NM_007449.3) Ang2 ENSMUST00000228835.1 NM_007449 Raa3 W0UV59 W0UV59_MOUSE uc288tom.1 uc288tom.2 Cytoplasmic vesicle, secretory vesicle lumen Nucleus, nucleolus Belongs to the pancreatic ribonuclease family. nucleic acid binding nuclease activity endonuclease activity hydrolase activity nucleic acid phosphodiester bond hydrolysis uc288tom.1 uc288tom.2 
ENSMUST00000228838.3 Gm32857 ENSMUST00000228838.3 Gm32857 (from geneSymbol) BC060994 ENSMUST00000228838.1 ENSMUST00000228838.2 uc288suo.1 uc288suo.2 uc288suo.3 uc288suo.1 uc288suo.2 uc288suo.3 
ENSMUST00000228842.2 Vmn1r181 ENSMUST00000228842.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q0P547) ENSMUST00000228842.1 M0QW73 Q0P547 Q0P547_MOUSE V1rd20 Vmn1r181 uc291msi.1 uc291msi.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291msi.1 uc291msi.2 
ENSMUST00000228843.2 Gm10876 ENSMUST00000228843.2 Gm10876 (from geneSymbol) AK137615 ENSMUST00000228843.1 uc288uma.1 uc288uma.2 uc288uma.1 uc288uma.2 
ENSMUST00000228844.2 Gm48958 ENSMUST00000228844.2 Gm48958 (from geneSymbol) AK158527 ENSMUST00000228844.1 uc288tcu.1 uc288tcu.2 uc288tcu.1 uc288tcu.2 
ENSMUST00000228849.2 ENSMUSG00000121298 ENSMUST00000228849.2 ENSMUSG00000121298 (from geneSymbol) ENSMUST00000228849.1 uc288ygl.1 uc288ygl.2 uc288ygl.1 uc288ygl.2 
ENSMUST00000228850.2 Gm49394 ENSMUST00000228850.2 Gm49394 (from geneSymbol) A0A2I3BPR3 A0A2I3BPR3_MOUSE BC058615 ENSMUST00000228850.1 Gm49394 uc291xkd.1 uc291xkd.2 activation of MAPK activity insulin receptor binding hormone activity extracellular region signal transduction response to organic substance regulation of gene expression glucose homeostasis positive regulation of peptidyl-tyrosine phosphorylation cytoplasm uc291xkd.1 uc291xkd.2 
ENSMUST00000228853.2 4930413F20Rik ENSMUST00000228853.2 RIKEN cDNA 4930413F20 gene (from RefSeq NR_045883.2) ENSMUST00000228853.1 NR_045883 uc029sol.1 uc029sol.2 uc029sol.1 uc029sol.2 
ENSMUST00000228854.2 Vmn1r220 ENSMUST00000228854.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R272) ENSMUST00000228854.1 Q8R272 Q8R272_MOUSE V1rh12 Vmn1r220 uc288lle.1 uc288lle.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288lle.1 uc288lle.2 
ENSMUST00000228865.2 Gm19510 ENSMUST00000228865.2 predicted gene, 19510 (from RefSeq NR_045076.1) ENSMUST00000228865.1 NR_045076 uc007vxy.1 uc007vxy.2 uc007vxy.1 uc007vxy.2 
ENSMUST00000228874.4 5830448L01Rik ENSMUST00000228874.4 5830448L01Rik (from geneSymbol) ENSMUST00000228874.1 ENSMUST00000228874.2 ENSMUST00000228874.3 LF199870 uc288skb.1 uc288skb.2 uc288skb.3 uc288skb.4 uc288skb.1 uc288skb.2 uc288skb.3 uc288skb.4 
ENSMUST00000228879.3 ENSMUSG00000121428 ENSMUST00000228879.3 ENSMUSG00000121428 (from geneSymbol) ENSMUST00000228879.1 ENSMUST00000228879.2 X78543 uc011zlw.1 uc011zlw.2 uc011zlw.3 uc011zlw.4 uc011zlw.1 uc011zlw.2 uc011zlw.3 uc011zlw.4 
ENSMUST00000228880.2 Vmn1r51 ENSMUST00000228880.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A0R4J266) A0A0R4J266 A0A0R4J266_MOUSE ENSMUST00000228880.1 Vmn1r51 Y12725 uc291gzx.1 uc291gzx.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc291gzx.1 uc291gzx.2 
ENSMUST00000228885.3 4930404K13Rik ENSMUST00000228885.3 4930404K13Rik (from geneSymbol) AK015085 ENSMUST00000228885.1 ENSMUST00000228885.2 uc288wnd.1 uc288wnd.2 uc288wnd.3 uc288wnd.1 uc288wnd.2 uc288wnd.3 
ENSMUST00000228889.2 Vmn1r203 ENSMUST00000228889.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R273) ENSMUST00000228889.1 Q8R273 Q8R273_MOUSE V1rh11 Vmn1r203 uc288liv.1 uc288liv.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc288liv.1 uc288liv.2 
ENSMUST00000228897.2 Gm32455 ENSMUST00000228897.2 predicted gene, 32455 (from RefSeq NR_153783.1) ENSMUST00000228897.1 NR_153783 uc288vyg.1 uc288vyg.2 uc288vyg.1 uc288vyg.2 
ENSMUST00000228909.2 Vmn1r29 ENSMUST00000228909.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q9EQ41) ENSMUST00000228909.1 G3X9L0 Q9EQ41 Q9EQ41_MOUSE V1rc2 Vmn1r29 uc291ewi.1 uc291ewi.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of chemical stimulus membrane integral component of membrane pheromone receptor activity response to pheromone uc291ewi.1 uc291ewi.2 
ENSMUST00000228911.2 Ppp3cc ENSMUST00000228911.2 protein phosphatase 3, catalytic subunit, gamma isoform, transcript variant 1 (from RefSeq NM_001304991.2) A0A2I3BPC5 A0A2I3BPC5_MOUSE ENSMUST00000228911.1 NM_001304991 Ppp3cc uc007unq.1 uc007unq.2 uc007unq.3 uc007unq.4 Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=; Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence= Name=Fe(3+); Xref=ChEBI:CHEBI:29034; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Belongs to the PPP phosphatase family. PP-2B subfamily. phosphoprotein phosphatase activity protein dephosphorylation hydrolase activity uc007unq.1 uc007unq.2 uc007unq.3 uc007unq.4 
ENSMUST00000228912.2 Gm48916 ENSMUST00000228912.2 Gm48916 (from geneSymbol) ENSMUST00000228912.1 LF285581 uc288xez.1 uc288xez.2 uc288xez.1 uc288xez.2 
ENSMUST00000228913.2 Ccdc202 ENSMUST00000228913.2 coiled-coil domain containing 202, transcript variant 2 (from RefSeq NM_001358241.1) 4921530L21Rik Ccdc202 ENSMUST00000228913.1 NM_001358241 Q9CQ47 Q9CQ47_MOUSE Spertl uc033gsi.1 uc033gsi.2 uc033gsi.3 molecular_function cellular_component biological_process uc033gsi.1 uc033gsi.2 uc033gsi.3 
ENSMUST00000228928.2 Gm49054 ENSMUST00000228928.2 Gm49054 (from geneSymbol) ENSMUST00000228928.1 uc288vye.1 uc288vye.2 uc288vye.1 uc288vye.2 
ENSMUST00000228929.2 4930402D18Rik ENSMUST00000228929.2 4930402D18Rik (from geneSymbol) AK015045 ENSMUST00000228929.1 uc007vyc.1 uc007vyc.2 uc007vyc.3 uc007vyc.1 uc007vyc.2 uc007vyc.3 
ENSMUST00000228931.2 Gm49016 ENSMUST00000228931.2 Gm49016 (from geneSymbol) AK133765 ENSMUST00000228931.1 uc288vvv.1 uc288vvv.2 uc288vvv.1 uc288vvv.2 
ENSMUST00000228934.2 Gm49163 ENSMUST00000228934.2 Gm49163 (from geneSymbol) ENSMUST00000228934.1 uc289hun.1 uc289hun.2 uc289hun.1 uc289hun.2 
ENSMUST00000228936.2 Ccdc198 ENSMUST00000228936.2 coiled-coil domain containing 198 (from RefSeq NM_025956.4) A9C481 C14orf105 Ccdc198 ENSMUST00000228936.1 FAME_MOUSE Fame NM_025956 Q8R0Q0 Q9CPZ1 uc007tke.1 uc007tke.2 uc007tke.3 uc007tke.4 May be involved in tuning the metabolism, energy expenditure, and excretion processes. Cell membrane ; Peripheral membrane protein Cytoplasmic vesicle Expressed in proximal tubules of the kidney. Deficient mice are viable without major developmental, morphological or behavioral defects. However, body weight and mean lean body mass are significantly altered in knockout mice. Mice display significant decrease in serum ferritin and high amount of albumin in the urine. Pregnant knockout females subjected to iron deficit diet, result in developing embryos with altered sizes of inner organs and interscapular brown adipose tissue. molecular_function cellular_component biological_process uc007tke.1 uc007tke.2 uc007tke.3 uc007tke.4 
ENSMUST00000228938.2 Gm49237 ENSMUST00000228938.2 Gm49237 (from geneSymbol) ENSMUST00000228938.1 uc288wet.1 uc288wet.2 uc288wet.1 uc288wet.2 
ENSMUST00000228949.2 Gm48996 ENSMUST00000228949.2 Gm48996 (from geneSymbol) ENSMUST00000228949.1 uc288xgd.1 uc288xgd.2 uc288xgd.1 uc288xgd.2 
ENSMUST00000228962.2 Snn ENSMUST00000228962.2 Snn (from geneSymbol) BC087932 ENSMUST00000228962.1 Q5M8P0 Q5M8P0_MOUSE Snn uc033gxo.1 uc033gxo.2 uc033gxo.3 cytoplasm mitochondrial outer membrane membrane integral component of membrane metal ion binding uc033gxo.1 uc033gxo.2 uc033gxo.3 
ENSMUST00000228977.2 Sco2 ENSMUST00000228977.2 Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2. (from UniProt Q8VCL2) AK013765 ENSMUST00000228977.1 Q8VCL2 SCO2_MOUSE uc289aqm.1 uc289aqm.2 Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2. Homodimer. Interacts with COA6. Found in a complex with TMEM177, COX20, COA6, MT-CO2/COX2, COX18 and SCO1. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20 in a MT- CO2/COX2- and COX18-dependent manner. Interacts with COX16. Mitochondrion inner membrane ; Single-pass membrane protein Expressed in retina, retinal pigment epithelium, and sclera. Belongs to the SCO1/2 family. eye development in utero embryonic development muscle system process copper ion binding mitochondrion mitochondrial inner membrane copper ion transport cellular copper ion homeostasis respiratory chain complex IV assembly response to activity protein disulfide oxidoreductase activity membrane integral component of membrane respiratory electron transport chain myofibril integral component of mitochondrial inner membrane mitochondrial respiratory chain complex IV assembly cell redox homeostasis metal ion binding copper ion homeostasis uc289aqm.1 uc289aqm.2 
ENSMUST00000228985.2 Nr4a1 ENSMUST00000228985.2 nuclear receptor subfamily 4, group A, member 1, transcript variant 3 (from RefSeq NM_001411254.1) ENSMUST00000228985.1 NM_001411254 Nr4a1 Q545Q1 Q545Q1_MOUSE uc289bnm.1 uc289bnm.2 In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Cytoplasm, cytosol Nucleus Belongs to the nuclear hormone receptor family. NR4 subfamily. transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding nucleus cytosol regulation of transcription, DNA-templated transcription factor binding zinc ion binding intracellular receptor signaling pathway nuclear membrane glucocorticoid receptor binding steroid hormone mediated signaling pathway sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter metal ion binding protein heterodimerization activity regulation of type B pancreatic cell proliferation uc289bnm.1 uc289bnm.2 
ENSMUST00000229028.2 St3gal1 ENSMUST00000229028.2 ST3 beta-galactoside alpha-2,3-sialyltransferase 1, transcript variant 1 (from RefSeq NM_009177.5) ENSMUST00000229028.1 NM_009177 Q544T4 Q544T4_MOUSE St3gal1 uc007wba.1 uc007wba.2 uc007wba.3 Reaction=a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:47560, ChEBI:CHEBI:15378, ChEBI:CHEBI:27938, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47561; Evidence=; Reaction=a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b + CMP + H(+); Xref=Rhea:RHEA:48244, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:88069, ChEBI:CHEBI:90151; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48245; Evidence=; Reaction=a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:18021, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:77709, ChEBI:CHEBI:78445; EC=2.4.3.2; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18022; Evidence=; Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) = CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+); Xref=Rhea:RHEA:48248, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:73110, ChEBI:CHEBI:90153; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48249; Evidence=; Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha- neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:21616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133470, ChEBI:CHEBI:139596; EC=2.4.3.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21617; Evidence=; Glycolipid biosynthesis. Protein modification; protein glycosylation. Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Secreted Belongs to the glycosyltransferase 29 family. beta-galactoside (CMP) alpha-2,3-sialyltransferase activity Golgi apparatus protein glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups sialylation uc007wba.1 uc007wba.2 uc007wba.3 
ENSMUST00000229053.2 Gm49484 ENSMUST00000229053.2 Gm49484 (from geneSymbol) ENSMUST00000229053.1 uc289bgg.1 uc289bgg.2 uc289bgg.1 uc289bgg.2 
ENSMUST00000229055.2 Zfp647 ENSMUST00000229055.2 zinc finger protein 647, transcript variant 2 (from RefSeq NM_172817.4) ENSMUST00000229055.1 NM_172817 Q7TNU6 Q8BJ57 ZN250_MOUSE Znf250 Znf647 uc007wmu.1 uc007wmu.2 uc007wmu.3 uc007wmu.4 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding DNA binding nucleus regulation of transcription, DNA-templated identical protein binding metal ion binding uc007wmu.1 uc007wmu.2 uc007wmu.3 uc007wmu.4 
ENSMUST00000229056.2 Gm49412 ENSMUST00000229056.2 Gm49412 (from geneSymbol) ENSMUST00000229056.1 LF200384 uc288zsh.1 uc288zsh.2 uc288zsh.1 uc288zsh.2 
ENSMUST00000229062.2 Gm49429 ENSMUST00000229062.2 Gm49429 (from geneSymbol) AK089814 ENSMUST00000229062.1 uc289aek.1 uc289aek.2 uc289aek.1 uc289aek.2 
ENSMUST00000229079.2 Gm49449 ENSMUST00000229079.2 Gm49449 (from geneSymbol) ENSMUST00000229079.1 uc289bdr.1 uc289bdr.2 uc289bdr.1 uc289bdr.2 
ENSMUST00000229080.2 Gm49475 ENSMUST00000229080.2 Gm49475 (from geneSymbol) ENSMUST00000229080.1 uc289biy.1 uc289biy.2 uc289biy.1 uc289biy.2 
ENSMUST00000229086.2 ENSMUSG00000121669 ENSMUST00000229086.2 ribosomal protein S15A, pseudogene 4 (from RefSeq NR_036572.1) ENSMUST00000229086.1 NR_036572 uc012dmd.1 uc012dmd.2 uc012dmd.3 uc012dmd.1 uc012dmd.2 uc012dmd.3 
ENSMUST00000229090.3 A930027H12Rik ENSMUST00000229090.3 RIKEN cDNA A930027H12 gene, transcript variant 1 (from RefSeq NR_167711.1) ENSMUST00000229090.1 ENSMUST00000229090.2 NR_167711 uc289ami.1 uc289ami.2 uc289ami.3 uc289ami.1 uc289ami.2 uc289ami.3 
ENSMUST00000229108.2 9530056E24Rik ENSMUST00000229108.2 9530056E24Rik (from geneSymbol) ENSMUST00000229108.1 uc290amt.1 uc290amt.2 uc290amt.1 uc290amt.2 
ENSMUST00000229110.2 Enthd1 ENSMUST00000229110.2 Enthd1 (from geneSymbol) BC158112 E9Q1Z2 E9Q1Z2_MOUSE ENSMUST00000229110.1 Enthd1 uc288zun.1 uc288zun.2 molecular_function cellular_component biological_process uc288zun.1 uc288zun.2 
ENSMUST00000229118.2 Gm49472 ENSMUST00000229118.2 Gm49472 (from geneSymbol) ENSMUST00000229118.1 uc289amk.1 uc289amk.2 uc289amk.1 uc289amk.2 
ENSMUST00000229130.2 Maff ENSMUST00000229130.2 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian), transcript variant 2 (from RefSeq NM_001304830.2) ENSMUST00000229130.1 Maff NM_001304830 Q3U0G5 Q3U0G5_MOUSE uc056yzm.1 uc056yzm.2 uc056yzm.3 DNA binding transcription factor activity, sequence-specific DNA binding nucleus mitochondrion regulation of transcription, DNA-templated sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter uc056yzm.1 uc056yzm.2 uc056yzm.3 
ENSMUST00000229162.2 AU021063 ENSMUST00000229162.2 expressed sequence AU021063 (from RefSeq NR_045996.1) ENSMUST00000229162.1 NR_045996 uc029svg.1 uc029svg.2 uc029svg.3 uc029svg.1 uc029svg.2 uc029svg.3 
ENSMUST00000229164.3 Gm49428 ENSMUST00000229164.3 Gm49428 (from geneSymbol) ENSMUST00000229164.1 ENSMUST00000229164.2 uc289boy.1 uc289boy.2 uc289boy.3 uc289boy.1 uc289boy.2 uc289boy.3 
ENSMUST00000229194.2 Gm49498 ENSMUST00000229194.2 Gm49498 (from geneSymbol) AK163289 ENSMUST00000229194.1 uc288ygx.1 uc288ygx.2 uc288ygx.1 uc288ygx.2 
ENSMUST00000229201.2 Gm30567 ENSMUST00000229201.2 Gm30567 (from geneSymbol) ENSMUST00000229201.1 uc289cih.1 uc289cih.2 uc289cih.1 uc289cih.2 
ENSMUST00000229206.2 Cd47 ENSMUST00000229206.2 CD47 antigen (Rh-related antigen, integrin-associated signal transducer), transcript variant 5 (from RefSeq NM_001368418.1) A0A2R8VK70 A0A2R8VK70_MOUSE Cd47 ENSMUST00000229206.1 NM_001368418 uc289eze.1 uc289eze.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein membrane integral component of membrane uc289eze.1 uc289eze.2 
ENSMUST00000229249.2 Gm49471 ENSMUST00000229249.2 Gm49471 (from geneSymbol) AK132860 ENSMUST00000229249.1 uc288zno.1 uc288zno.2 uc288zno.1 uc288zno.2 
ENSMUST00000229317.2 7530414M10Rik ENSMUST00000229317.2 7530414M10Rik (from geneSymbol) AK078693 ENSMUST00000229317.1 uc289agn.1 uc289agn.2 uc289agn.1 uc289agn.2 
ENSMUST00000229365.2 Gm49593 ENSMUST00000229365.2 Gm49593 (from geneSymbol) AK043585 ENSMUST00000229365.1 uc057bgp.1 uc057bgp.2 uc057bgp.1 uc057bgp.2 
ENSMUST00000229368.2 Gm49469 ENSMUST00000229368.2 RIKEN cDNA A930027H12 gene, transcript variant 2 (from RefSeq NR_167712.1) ENSMUST00000229368.1 NR_167712 uc289amf.1 uc289amf.2 uc289amf.1 uc289amf.2 
ENSMUST00000229371.2 Smug1 ENSMUST00000229371.2 Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5- formylcytosine), nor other oxidized bases. The activity is damage- specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. (from UniProt Q6P5C5) AK004735 ENSMUST00000229371.1 Q6P5C5 Q9DBV1 SMUG1_MOUSE uc289bwp.1 uc289bwp.2 Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5- formylcytosine), nor other oxidized bases. The activity is damage- specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. Nucleus Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family. oxidized base lesion DNA N-glycosylase activity oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity DNA binding single-stranded DNA binding uracil DNA N-glycosylase activity nucleus nucleolus DNA repair base-excision repair cellular response to DNA damage stimulus hydrolase activity single-strand selective uracil DNA N-glycosylase activity DNA N-glycosylase activity uc289bwp.1 uc289bwp.2 
ENSMUST00000229379.3 Gm33696 ENSMUST00000229379.3 Gm33696 (from geneSymbol) ENSMUST00000229379.1 ENSMUST00000229379.2 uc289cqm.1 uc289cqm.2 uc289cqm.3 uc289cqm.1 uc289cqm.2 uc289cqm.3 
ENSMUST00000229390.2 Gm49502 ENSMUST00000229390.2 Gm49502 (from geneSymbol) AK165135 ENSMUST00000229390.1 uc289abp.1 uc289abp.2 uc289abp.1 uc289abp.2 
ENSMUST00000229391.3 ENSMUSG00000121431 ENSMUST00000229391.3 ENSMUSG00000121431 (from geneSymbol) ENSMUST00000229391.1 ENSMUST00000229391.2 uc288ziq.1 uc288ziq.2 uc288ziq.3 uc288ziq.1 uc288ziq.2 uc288ziq.3 
ENSMUST00000229441.2 Elfn2 ENSMUST00000229441.2 leucine rich repeat and fibronectin type III, extracellular 2, transcript variant 2 (from RefSeq NM_183141.3) ENSMUST00000229441.1 Kiaa1904 Lrrc62 NM_183141 PPR29_MOUSE Ppp1r29 Q68FM6 Q69Z72 Q8CCW8 uc007wrf.1 uc007wrf.2 uc007wrf.3 uc007wrf.4 Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Interacts with PPP1CA. Membrane ; Single-pass membrane protein protein phosphatase inhibitor activity extracellular space negative regulation of phosphatase activity membrane integral component of membrane extracellular matrix negative regulation of phosphoprotein phosphatase activity uc007wrf.1 uc007wrf.2 uc007wrf.3 uc007wrf.4 
ENSMUST00000229446.2 Gm49521 ENSMUST00000229446.2 Gm49521 (from geneSymbol) ENSMUST00000229446.1 uc289crr.1 uc289crr.2 uc289crr.1 uc289crr.2 
ENSMUST00000229453.2 Gm35974 ENSMUST00000229453.2 Gm35974 (from geneSymbol) AK139879 ENSMUST00000229453.1 uc289bza.1 uc289bza.2 uc289bza.1 uc289bza.2 
ENSMUST00000229479.3 Gm49481 ENSMUST00000229479.3 Gm49481 (from geneSymbol) AK132810 ENSMUST00000229479.1 ENSMUST00000229479.2 uc288zko.1 uc288zko.2 uc288zko.1 uc288zko.2 
ENSMUST00000229538.2 D030024E09Rik ENSMUST00000229538.2 D030024E09Rik (from geneSymbol) AK163289 ENSMUST00000229538.1 uc007vye.1 uc007vye.2 uc007vye.3 uc007vye.1 uc007vye.2 uc007vye.3 
ENSMUST00000229580.2 Gm49479 ENSMUST00000229580.2 Gm49479 (from geneSymbol) AK079523 ENSMUST00000229580.1 uc289brl.1 uc289brl.2 uc289brl.1 uc289brl.2 
ENSMUST00000229584.2 Gm35853 ENSMUST00000229584.2 Gm35853 (from geneSymbol) AK138921 ENSMUST00000229584.1 uc007xsy.1 uc007xsy.2 uc007xsy.1 uc007xsy.2 
ENSMUST00000229609.2 Anks6 ENSMUST00000229609.2 ankyrin repeat and sterile alpha motif domain containing 6, transcript variant 1 (from RefSeq NM_001356426.1) ANKS6_MOUSE ENSMUST00000229609.1 Gm635 NM_001356426 Q6GQX6 Samd6 uc290moq.1 uc290moq.2 Required for renal function. Homooligomer (By similarity). Central component of a complex containing at least ANKS6, INVS, NEK8 and NPHP3 (By similarity). ANKS6 may organize complex assembly by linking INVS and NPHP3 to NEK8 and INVS may target the complex to the proximal ciliary axoneme (By similarity). Interacts (via SAM domain) with BICC1 (via KH domains) in an RNA-dependent manner (By similarity). Interacts (via SAM domain) with ANKS3 (via SAM domain) (PubMed:25671767, PubMed:26327442). Cell projection, cilium Cytoplasm Note=Localizes to the proximal region of the primary cilium in the presence of INVS. Expressed in kidney (at protein level). The ankyrin repeats are necessary and sufficient for NEK8- binding. Hydroxylated at Asn-129, most probably by HIF1AN. This hydroxylation results in decreased NEK8-binding. Sequence=AAH72562.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; in utero embryonic development protein binding cytoplasm cilium determination of left/right symmetry heart development protein homodimerization activity cell projection uc290moq.1 uc290moq.2 
ENSMUST00000229641.2 Gfus ENSMUST00000229641.2 GDP-L-fucose synthase, transcript variant 2 (from RefSeq NM_001357005.2) ENSMUST00000229641.1 Gfus NM_001357005 Q5HZI6 Q5HZI6_MOUSE Tsta3 uc007wht.1 uc007wht.2 uc007wht.3 Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2. Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. catalytic activity nucleotide-sugar biosynthetic process oxidoreductase activity GDP-mannose metabolic process 'de novo' GDP-L-fucose biosynthetic process identical protein binding GDP-mannose 3,5-epimerase activity GDP-L-fucose synthase activity coenzyme binding oxidation-reduction process uc007wht.1 uc007wht.2 uc007wht.3 
ENSMUST00000229653.3 Gm49439 ENSMUST00000229653.3 Gm49439 (from geneSymbol) ENSMUST00000229653.1 ENSMUST00000229653.2 uc288xwg.1 uc288xwg.2 uc288xwg.3 uc288xwg.1 uc288xwg.2 uc288xwg.3 
ENSMUST00000229665.2 Gm49492 ENSMUST00000229665.2 Gm49492 (from geneSymbol) AK044077 ENSMUST00000229665.1 uc289bky.1 uc289bky.2 uc289bky.1 uc289bky.2 
ENSMUST00000229679.2 Gpt ENSMUST00000229679.2 Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). (from UniProt Q8QZR5) ALAT1_MOUSE BC022625 ENSMUST00000229679.1 Gpt1 Q8QZR5 uc288zez.1 uc288zez.2 Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). Reaction=2-oxoglutarate + L-alanine = L-glutamate + pyruvate; Xref=Rhea:RHEA:19453, ChEBI:CHEBI:15361, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57972; EC=2.6.1.2; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1. Homodimer. Cytoplasm Mainly expressed in liver, intestine, colon and white adipose tissue. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. catalytic activity L-alanine:2-oxoglutarate aminotransferase activity extracellular space cytoplasm transaminase activity biosynthetic process transferase activity pyridoxal phosphate binding L-alanine catabolic process uc288zez.1 uc288zez.2 
ENSMUST00000229682.3 Gm4544 ENSMUST00000229682.3 Gm4544 (from geneSymbol) AK139359 ENSMUST00000229682.1 ENSMUST00000229682.2 uc289bvl.1 uc289bvl.2 uc289bvl.3 uc289bvl.1 uc289bvl.2 uc289bvl.3 
ENSMUST00000229685.2 A930001M01Rik ENSMUST00000229685.2 A930001M01Rik (from geneSymbol) AK044532 ENSMUST00000229685.1 uc007xeb.1 uc007xeb.2 uc007xeb.3 uc007xeb.1 uc007xeb.2 uc007xeb.3 
ENSMUST00000229686.2 Gm34939 ENSMUST00000229686.2 predicted gene, 34939 (from RefSeq NR_168656.1) ENSMUST00000229686.1 NR_168656 uc289bhk.1 uc289bhk.2 uc289bhk.1 uc289bhk.2 
ENSMUST00000229695.4 4833415N18Rik ENSMUST00000229695.4 4833415N18Rik (from geneSymbol) AK014704 ENSMUST00000229695.1 ENSMUST00000229695.2 ENSMUST00000229695.3 uc289cmf.1 uc289cmf.2 uc289cmf.3 uc289cmf.4 uc289cmf.1 uc289cmf.2 uc289cmf.3 uc289cmf.4 
ENSMUST00000229696.2 Tfcp2 ENSMUST00000229696.2 transcription factor CP2, transcript variant 1 (from RefSeq NM_033476.3) ENSMUST00000229696.1 NM_033476 Q3UGJ4 Q8VC13 Q9ERA0 TFCP2_MOUSE Tcfcp2 uc007xrl.1 uc007xrl.2 uc007xrl.3 uc007xrl.4 Binds a variety of cellular promoters including fibrinogen, alpha-globin promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter (By similarity). Binds to DNA as a dimer. Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1. Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9ERA0-1; Sequence=Displayed; Name=2; IsoId=Q9ERA0-2; Sequence=VSP_017650; Name=3; IsoId=Q9ERA0-3; Sequence=VSP_017649; Belongs to the grh/CP2 family. CP2 subfamily. RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm transcription factor complex cytosol regulation of transcription from RNA polymerase II promoter protein C-terminus binding transcription factor binding macromolecular complex mRNA transcription from RNA polymerase II promoter sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter uc007xrl.1 uc007xrl.2 uc007xrl.3 uc007xrl.4 
ENSMUST00000229702.3 Gm36738 ENSMUST00000229702.3 Gm36738 (from geneSymbol) AK085438 ENSMUST00000229702.1 ENSMUST00000229702.2 uc007wpq.1 uc007wpq.2 uc007wpq.3 uc007wpq.4 uc007wpq.1 uc007wpq.2 uc007wpq.3 uc007wpq.4 
ENSMUST00000229709.3 Gm49432 ENSMUST00000229709.3 Gm49432 (from geneSymbol) ENSMUST00000229709.1 ENSMUST00000229709.2 uc289cnw.1 uc289cnw.2 uc289cnw.3 uc289cnw.1 uc289cnw.2 uc289cnw.3 
ENSMUST00000229726.2 Gm49438 ENSMUST00000229726.2 Gm49438 (from geneSymbol) AK080476 ENSMUST00000229726.1 uc288xwf.1 uc288xwf.2 uc288xwf.1 uc288xwf.2 
ENSMUST00000229741.2 Rbfox1 ENSMUST00000229741.2 RNA binding protein, fox-1 homolog (C. elegans) 1, transcript variant 1 (from RefSeq NM_183188.3) A2bp A2bp1 ENSMUST00000229741.1 Fox1 MNCb-3035 NM_183188 Q3UYA8 Q537C9 Q537D0 Q537D1 Q537D2 Q6PD12 Q8R4Z7 Q9JJ43 Q9JJB5 RFOX1_MOUSE uc007ycf.1 uc007ycf.2 uc007ycf.3 uc007ycf.4 RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue- specific exons and of differentially spliced exons during erythropoiesis. Binds to the C-terminus of ATXN2. Nucleus. Cytoplasm. Note=Predominantly nuclear. Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=A016; IsoId=Q9JJ43-1; Sequence=Displayed; Name=2; IsoId=Q9JJ43-2; Sequence=VSP_030879; Name=3; Synonyms=A713; IsoId=Q9JJ43-3; Sequence=VSP_030880, VSP_030883; Name=4; IsoId=Q9JJ43-4; Sequence=VSP_030882; Name=5; Synonyms=2, A030; IsoId=Q9JJ43-5; Sequence=VSP_030884; Name=6; Synonyms=4, A715; IsoId=Q9JJ43-6; Sequence=VSP_030880, VSP_030883, VSP_030884; Name=7; Synonyms=5, A704; IsoId=Q9JJ43-7; Sequence=VSP_030880, VSP_030881, VSP_030883, VSP_030884; Detected in brain (at protein level). Detected in heart, brain, neurons, skeletal muscle and embryo. regulation of alternative mRNA splicing, via spliceosome nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding nucleus nucleoplasm cytoplasm trans-Golgi network mRNA processing nervous system development protein C-terminus binding RNA splicing regulation of RNA splicing neuromuscular process controlling balance regulation of skeletal muscle cell differentiation uc007ycf.1 uc007ycf.2 uc007ycf.3 uc007ycf.4 
ENSMUST00000229754.2 4930573C08Rik ENSMUST00000229754.2 4930573C08Rik (from geneSymbol) AK016287 ENSMUST00000229754.1 uc288ynn.1 uc288ynn.2 uc288ynn.1 uc288ynn.2 
ENSMUST00000229763.2 Gm46519 ENSMUST00000229763.2 Gm46519 (from geneSymbol) AK049024 ENSMUST00000229763.1 uc288ytu.1 uc288ytu.2 uc288ytu.1 uc288ytu.2 
ENSMUST00000229764.2 Gm10832 ENSMUST00000229764.2 Gm10832 (from geneSymbol) AK136598 ENSMUST00000229764.1 uc289ckj.1 uc289ckj.2 uc289ckj.1 uc289ckj.2 
ENSMUST00000229780.2 Gm36644 ENSMUST00000229780.2 Gm36644 (from geneSymbol) ENSMUST00000229780.1 uc288zks.1 uc288zks.2 uc288zks.1 uc288zks.2 
ENSMUST00000229850.2 Gm49526 ENSMUST00000229850.2 Gm49526 (from geneSymbol) AK032499 ENSMUST00000229850.1 uc288xvo.1 uc288xvo.2 uc288xvo.1 uc288xvo.2 
ENSMUST00000229866.2 Socs1 ENSMUST00000229866.2 suppressor of cytokine signaling 1, transcript variant 1 (from RefSeq NM_001271603.1) A2RT46 Cish1 ENSMUST00000229866.1 NM_001271603 O35716 O35960 Q3U3L0 SOCS1_MOUSE Socs1 Ssi1 uc033gxm.1 uc033gxm.2 uc033gxm.3 uc033gxm.4 Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:9202125, PubMed:10064597, PubMed:15169905, PubMed:15522878). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity (PubMed:9202125, PubMed:10064597, PubMed:15522878). In vitro, suppresses Tec protein-tyrosine activity (By similarity). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Protein modification; protein ubiquitination. Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domain to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV. Interacts with the Elongin BC complex (ELOB and ELOC). Component of an ECS CBC(SOCS1) E3 ubiquitin- protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1. Interacts (via SH2 domain and SOCS box) with TRIM8. Interacts with CUL2. Interacts with AXL and FGFR3 (By similarity). Interacts with INSR. Interacts with TRIM8 (By similarity). Interacts with DCUN1D1 (By similarity). Interacts with IFNGR1 (PubMed:15522878). Nucleus Cytoplasmic vesicle Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3. High expression in thymus. Lower expression in lung and spleen (PubMed:9202125). Expressed in both Th1 and Th2 cells. In the developing brain, expressed at low levels from 10 dpc stages to young adulthood (P25) with peak levels from 14 dpc to P8. In the cortex, expression first observed at 14 dpc uniformly in all cells. Also expressed in the innermost layers of the developing retina. Levels of expression remain unchanged from P8 until adulthood. In the peripheral nervous system, high levels found in virtually all neurons of the dorsal root ganglion. By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating factor families. The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC- box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box. Mice exhibit lymphocyte deficiency and degeneration of the liver parenchyma. Animals die within 3 weeks of age. Mutants show a much higher frequency of CD8 single positive thymocytes (PubMed:24880459). Belongs to the SOCS1 family. regulation of protein phosphorylation insulin-like growth factor receptor binding protein binding nucleus nucleoplasm cytoplasm cytosol phosphatidylinositol 3-kinase complex JAK-STAT cascade negative regulation of signal transduction regulation of activation of Janus kinase activity protein ubiquitination kinase inhibitor activity cytokine-mediated signaling pathway protein kinase binding cytoplasmic vesicle negative regulation of kinase activity intracellular signal transduction cytoplasmic ribonucleoprotein granule regulation of growth regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein positive regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of CD8-positive, alpha-beta T cell differentiation regulation of phosphatidylinositol 3-kinase activity fat cell differentiation positive regulation of regulatory T cell differentiation regulation of JAK-STAT cascade negative regulation of JAK-STAT cascade negative regulation of insulin receptor signaling pathway phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity regulation of cytokine secretion regulation of interferon-gamma-mediated signaling pathway cellular response to amino acid stimulus cellular response to cytokine stimulus cellular response to organic cyclic compound uc033gxm.1 uc033gxm.2 uc033gxm.3 uc033gxm.4 
ENSMUST00000229871.2 Gm49548 ENSMUST00000229871.2 Gm49548 (from geneSymbol) ENSMUST00000229871.1 uc289alb.1 uc289alb.2 uc289alb.1 uc289alb.2 
ENSMUST00000229889.3 Gm46526 ENSMUST00000229889.3 Gm46526 (from geneSymbol) ENSMUST00000229889.1 ENSMUST00000229889.2 uc289aip.1 uc289aip.2 uc289aip.3 uc289aip.1 uc289aip.2 uc289aip.3 
ENSMUST00000229899.2 Gm36480 ENSMUST00000229899.2 predicted gene, 36480 (from RefSeq NR_155426.1) ENSMUST00000229899.1 NR_155426 uc007xhl.1 uc007xhl.2 uc007xhl.3 uc007xhl.1 uc007xhl.2 uc007xhl.3 
ENSMUST00000229927.3 Gm49499 ENSMUST00000229927.3 Gm49499 (from geneSymbol) AK144023 ENSMUST00000229927.1 ENSMUST00000229927.2 uc289bnt.1 uc289bnt.2 uc289bnt.3 uc289bnt.1 uc289bnt.2 uc289bnt.3 
ENSMUST00000229929.2 Gm49420 ENSMUST00000229929.2 Gm49420 (from geneSymbol) ENSMUST00000229929.1 uc289auk.1 uc289auk.2 uc289auk.1 uc289auk.2 
ENSMUST00000229963.2 Gm5478 ENSMUST00000229963.2 Gm5478 (from geneSymbol) A0A2R8VHP3 A0A2R8VHP3_MOUSE BC046626 ENSMUST00000229963.1 Gm5478 uc289bot.1 uc289bot.2 intermediate filament keratin filament uc289bot.1 uc289bot.2 
ENSMUST00000229974.2 Gm49466 ENSMUST00000229974.2 Gm49466 (from geneSymbol) ENSMUST00000229974.1 uc289amb.1 uc289amb.2 uc289amb.1 uc289amb.2 
ENSMUST00000229980.2 Grap2 ENSMUST00000229980.2 GRB2-related adaptor protein 2, transcript variant 2 (from RefSeq NM_001289442.1) ENSMUST00000229980.1 Grap2 NM_001289442 Q3U0E8 Q3U0E8_MOUSE uc007wvo.1 uc007wvo.2 uc007wvo.3 uc007wvo.4 nucleus cytoplasm endosome uc007wvo.1 uc007wvo.2 uc007wvo.3 uc007wvo.4 
ENSMUST00000230013.2 4930578M01Rik ENSMUST00000230013.2 4930578M01Rik (from geneSymbol) AK016307 ENSMUST00000230013.1 uc289bdt.1 uc289bdt.2 uc289bdt.1 uc289bdt.2 
ENSMUST00000230029.2 Gm41333 ENSMUST00000230029.2 Gm41333 (from geneSymbol) ENSMUST00000230029.1 uc288yhp.1 uc288yhp.2 uc288yhp.1 uc288yhp.2 
ENSMUST00000230034.2 Gm49436 ENSMUST00000230034.2 Gm49436 (from geneSymbol) AK086469 ENSMUST00000230034.1 uc288zhv.1 uc288zhv.2 uc288zhv.1 uc288zhv.2 
ENSMUST00000230049.3 ENSMUSG00000121336 ENSMUST00000230049.3 ENSMUSG00000121336 (from geneSymbol) ENSMUST00000230049.1 ENSMUST00000230049.2 uc289wpk.1 uc289wpk.2 uc289wpk.3 uc289wpk.1 uc289wpk.2 uc289wpk.3 
ENSMUST00000230054.2 Troap ENSMUST00000230054.2 Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. (from UniProt B7ZNG4) B7ZNG4 BC145227 ENSMUST00000230054.1 Q497S4 Q8BWP3 TROAP_MOUSE Troap uc007xos.1 uc007xos.2 uc007xos.3 uc007xos.4 Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly binds bystin, and indirectly trophinin. Cytoplasm Sequence=AAI00406.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component cytoplasm cell adhesion biological_process uc007xos.1 uc007xos.2 uc007xos.3 uc007xos.4 
ENSMUST00000230067.3 Krt85 ENSMUST00000230067.3 keratin 85 (from RefSeq NM_016879.3) ENSMUST00000230067.1 ENSMUST00000230067.2 KRT85_MOUSE Krt2-18 Krthb5 NM_016879 Q8CE83 Q9D7M4 Q9Z2T6 uc289bok.1 uc289bok.2 Heterotetramer of two type I and two type II keratins. There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). Belongs to the intermediate filament family. intermediate filament keratin filament uc289bok.1 uc289bok.2 
ENSMUST00000230075.2 Aqp6 ENSMUST00000230075.2 Membrane ; Multi- pass membrane protein (from UniProt Q14BV5) AQP6 Aqp6 BC115586 ENSMUST00000230075.1 Q14BV5 Q14BV5_MOUSE uc007xpv.1 uc007xpv.2 Membrane ; Multi- pass membrane protein Belongs to the MIP/aquaporin (TC 1.A.8) family. channel activity porin activity membrane integral component of membrane pore complex transmembrane transport uc007xpv.1 uc007xpv.2 
ENSMUST00000230081.2 5730521K06Rik ENSMUST00000230081.2 5730521K06Rik (from geneSymbol) ENSMUST00000230081.1 uc288zcw.1 uc288zcw.2 uc288zcw.1 uc288zcw.2 
ENSMUST00000230109.2 9430014N10Rik ENSMUST00000230109.2 RIKEN cDNA 9430014N10 gene (from RefSeq NR_045737.1) ENSMUST00000230109.1 NR_045737 uc029suv.1 uc029suv.2 uc029suv.1 uc029suv.2 
ENSMUST00000230118.2 Gm31462 ENSMUST00000230118.2 predicted gene, 31462 (from RefSeq NR_188860.1) ENSMUST00000230118.1 NR_188860 uc288zvv.1 uc288zvv.2 uc288zvv.1 uc288zvv.2 
ENSMUST00000230130.2 5730414N17Rik ENSMUST00000230130.2 5730414N17Rik (from geneSymbol) ENSMUST00000230130.1 uc289bcw.1 uc289bcw.2 uc289bcw.1 uc289bcw.2 
ENSMUST00000230156.2 Gm49410 ENSMUST00000230156.2 Gm49410 (from geneSymbol) AK036962 ENSMUST00000230156.1 uc288ziy.1 uc288ziy.2 uc288ziy.1 uc288ziy.2 
ENSMUST00000230162.2 Gm49525 ENSMUST00000230162.2 Gm49525 (from geneSymbol) AK042823 ENSMUST00000230162.1 uc288xvn.1 uc288xvn.2 uc288xvn.1 uc288xvn.2 
ENSMUST00000230173.2 Gm49501 ENSMUST00000230173.2 Gm49501 (from geneSymbol) AK028881 ENSMUST00000230173.1 uc289bog.1 uc289bog.2 uc289bog.1 uc289bog.2 
ENSMUST00000230175.2 ENSMUSG00000115902 ENSMUST00000230175.2 ENSMUSG00000115902 (from geneSymbol) ENSMUST00000230175.1 uc288zsi.1 uc288zsi.2 uc288zsi.1 uc288zsi.2 
ENSMUST00000230183.2 1700041B01Rik ENSMUST00000230183.2 1700041B01Rik (from geneSymbol) AK018845 ENSMUST00000230183.1 uc007wrh.1 uc007wrh.2 uc007wrh.3 uc007wrh.1 uc007wrh.2 uc007wrh.3 
ENSMUST00000230208.3 Gm31369 ENSMUST00000230208.3 predicted gene, 31369, transcript variant 2 (from RefSeq NR_155275.1) ENSMUST00000230208.1 ENSMUST00000230208.2 NR_155275 uc288zul.1 uc288zul.2 uc288zul.3 uc288zul.1 uc288zul.2 uc288zul.3 
ENSMUST00000230209.4 Lncpint ENSMUST00000230209.4 Lncpint (from geneSymbol) ENSMUST00000230209.1 ENSMUST00000230209.2 ENSMUST00000230209.3 KC860259 uc291dhe.1 uc291dhe.2 uc291dhe.3 uc291dhe.4 uc291dhe.1 uc291dhe.2 uc291dhe.3 uc291dhe.4 
ENSMUST00000230210.2 Gm49455 ENSMUST00000230210.2 Gm49455 (from geneSymbol) ENSMUST00000230210.1 uc289cis.1 uc289cis.2 uc289cis.1 uc289cis.2 
ENSMUST00000230214.2 Gm49527 ENSMUST00000230214.2 Gm49527 (from geneSymbol) A0A2R8VHE3 A0A2R8VHE3_MOUSE BC025891 ENSMUST00000230214.1 Gm49527 uc033guw.1 uc033guw.2 uc033guw.3 nucleic acid binding regulation of transcription, DNA-templated uc033guw.1 uc033guw.2 uc033guw.3 
ENSMUST00000230226.2 Tmprss6 ENSMUST00000230226.2 transmembrane serine protease 6, transcript variant 2 (from RefSeq NM_001355601.1) A0A2R8W6T9 A0A2R8W6T9_MOUSE ENSMUST00000230226.1 NM_001355601 Tmprss6 uc007wpj.1 uc007wpj.2 uc007wpj.3 Cell membrane ; Single-pass type II membrane protein Membrane ; Single-pass type II membrane protein Lacks conserved residue(s) required for the propagation of feature annotation. serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity uc007wpj.1 uc007wpj.2 uc007wpj.3 
ENSMUST00000230236.3 Gm36329 ENSMUST00000230236.3 Gm36329 (from geneSymbol) ENSMUST00000230236.1 ENSMUST00000230236.2 uc288ziv.1 uc288ziv.2 uc288ziv.3 uc288ziv.1 uc288ziv.2 uc288ziv.3 
ENSMUST00000230264.3 Csf2rb ENSMUST00000230264.3 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage), transcript variant 1 (from RefSeq NM_001358854.1) Aic2b Csf2rb1 ENSMUST00000230264.1 ENSMUST00000230264.2 IL3RB_MOUSE Il3rb1 NM_001358854 P26955 Q3U7L5 uc007woz.1 uc007woz.2 uc007woz.3 uc007woz.4 High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. Heterodimer of an alpha and a beta subunit (PubMed:10477686). The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2 (By similarity). Interacts with FCER1G; this interaction is direct (PubMed:19098920). Interacts with LYN. P26955; P09055: Itgb1; NbExp=2; IntAct=EBI-1810026, EBI-644224; P26955; P05532: Kit; NbExp=4; IntAct=EBI-1810026, EBI-8559255; Membrane; Single-pass type I membrane protein. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. May be phosphorylated by LYN. Belongs to the type I cytokine receptor family. Type 4 subfamily. regulation of cell growth cytokine receptor activity protein binding membrane integral component of membrane cytokine-mediated signaling pathway uc007woz.1 uc007woz.2 uc007woz.3 uc007woz.4 
ENSMUST00000230271.2 Polr2f ENSMUST00000230271.2 polymerase (RNA) II (DNA directed) polypeptide F (from RefSeq NM_027231.2) ENSMUST00000230271.1 NM_027231 P61219 Polr2f RPAB2_MOUSE uc007wst.1 uc007wst.2 uc007wst.3 uc007wst.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of POLR2A/RPB1 and POLR2B/RPB2 forms a pocket to which the POLR2D/RPB4-POLR2G/RPB7 subcomplex binds (By similarity). Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. The transcriptionally active Pol III complex consists of a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4- POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Nucleus Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family. fibrillar center DNA binding DNA-directed 5'-3' RNA polymerase activity nucleus nucleoplasm DNA-directed RNA polymerase II, core complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase I complex transcription, DNA-templated transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter transcription from RNA polymerase III promoter RNA polymerase I activity RNA polymerase II activity RNA polymerase III activity uc007wst.1 uc007wst.2 uc007wst.3 uc007wst.4 
ENSMUST00000230277.2 Gm32405 ENSMUST00000230277.2 Gm32405 (from geneSymbol) ENSMUST00000230277.1 uc288yqk.1 uc288yqk.2 uc288yqk.1 uc288yqk.2 
ENSMUST00000230278.2 Gm49504 ENSMUST00000230278.2 Gm49504 (from geneSymbol) ENSMUST00000230278.1 uc289byw.1 uc289byw.2 uc289byw.1 uc289byw.2 
ENSMUST00000230284.2 Gm49441 ENSMUST00000230284.2 Gm49441 (from geneSymbol) ENSMUST00000230284.1 uc288xwi.1 uc288xwi.2 uc288xwi.1 uc288xwi.2 
ENSMUST00000230293.2 Gm49544 ENSMUST00000230293.2 Gm49544 (from geneSymbol) AK052663 ENSMUST00000230293.1 uc288znf.1 uc288znf.2 uc288znf.1 uc288znf.2 
ENSMUST00000230362.2 Septin12 ENSMUST00000230362.2 septin 12, transcript variant 3 (from RefSeq NM_001373945.1) A0A2R8VJU7 A0A2R8VJU7_MOUSE ENSMUST00000230362.1 NM_001373945 Sept12 Septin12 uc289ceu.1 uc289ceu.2 Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. nucleotide binding GTPase activity GTP binding spindle septin ring microtubule cytoskeleton midbody septin complex identical protein binding protein homodimerization activity perinuclear region of cytoplasm cytoskeleton-dependent cytokinesis sperm annulus uc289ceu.1 uc289ceu.2 
ENSMUST00000230383.2 Gm52969 ENSMUST00000230383.2 Gm52969 (from geneSymbol) AK139628 ENSMUST00000230383.1 uc289duz.1 uc289duz.2 uc289duz.1 uc289duz.2 
ENSMUST00000230387.3 4930513L16Rik ENSMUST00000230387.3 RIKEN cDNA 4930513L16 gene (from RefSeq NR_166787.1) ENSMUST00000230387.1 ENSMUST00000230387.2 NR_166787 uc007xcp.1 uc007xcp.2 uc007xcp.3 uc007xcp.4 uc007xcp.1 uc007xcp.2 uc007xcp.3 uc007xcp.4 
ENSMUST00000230389.3 Gm34643 ENSMUST00000230389.3 predicted gene, 34643 (from RefSeq NR_166851.1) ENSMUST00000230389.1 ENSMUST00000230389.2 NR_166851 uc057ktj.1 uc057ktj.2 uc057ktj.3 uc057ktj.4 uc057ktj.1 uc057ktj.2 uc057ktj.3 uc057ktj.4 
ENSMUST00000230425.2 Gm17753 ENSMUST00000230425.2 predicted gene 10865 (from RefSeq NR_045746.1) ENSMUST00000230425.1 NR_045746 uc029sti.1 uc029sti.2 uc029sti.1 uc029sti.2 
ENSMUST00000230426.2 Gm49460 ENSMUST00000230426.2 Gm49460 (from geneSymbol) ENSMUST00000230426.1 uc288yok.1 uc288yok.2 uc288yok.1 uc288yok.2 
ENSMUST00000230446.2 Ddit3 ENSMUST00000230446.2 [Isoform AltDDIT3]: Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP. (from UniProt A0A2R8VHR8) A0A2R8VHR8 BC013718 DT3UO_MOUSE Ddit3 ENSMUST00000230446.1 uc287vmz.1 uc287vmz.2 [Isoform AltDDIT3]: Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP. Interacts with DDIT3 (isoform 1). Nucleus Cytoplasm Note=Colocalizes with WDR83 in the cytoplasm. Event=Alternative initiation; Named isoforms=2; Name=AltDDIT3; IsoId=A0A2R8VHR8-1; Sequence=Displayed; Name=1; IsoId=P35639-1; Sequence=External; [Isoform AltDDIT3]: Produced in absence of stress: this uORF is translated, thereby preventing translation of downstream ORF, the stress effector DDIT3/CHOP (PubMed:21285359). This uORF is not translated in response to stress (PubMed:21285359). [Isoform AltDDIT3]: Product of the upstream open reading frame of this bicistronic gene. uc287vmz.1 uc287vmz.2 
ENSMUST00000230449.2 Gm49474 ENSMUST00000230449.2 Gm49474 (from geneSymbol) ENSMUST00000230449.1 uc289biv.1 uc289biv.2 uc289biv.1 uc289biv.2 
ENSMUST00000230490.2 Cacnb3 ENSMUST00000230490.2 calcium channel, voltage-dependent, beta 3 subunit, transcript variant 9 (from RefSeq NR_177065.1) CACB3_MOUSE Cacnlb3 ENSMUST00000230490.1 G5E821 NR_177065 P54285 uc007xnc.1 uc007xnc.2 uc007xnc.3 uc007xnc.4 Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:24751537). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Component of a calcium channel complex consisting of a pore- forming alpha subunit (CACNA1C) and the ancillary subunits CACNB3 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio. Interacts with CACNA2D4. Interacts with FASLG (By similarity). Interacts with CBARP; prevents the interaction of CACNB3 with the alpha subunit CACNA1C thereby negatively regulating the activity of the corresponding calcium channel (PubMed:24751537). Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=3A; IsoId=P54285-1; Sequence=Displayed; Name=3B; IsoId=P54285-2; Sequence=Not described; Detected in the inner plexiform layer in the retina (at protein level). Belongs to the calcium channel beta subunit family. voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel regulator activity calcium channel activity protein binding cytoplasm plasma membrane voltage-gated calcium channel complex ion transport calcium ion transport chemical synaptic transmission neuromuscular junction development high voltage-gated calcium channel activity membrane apical plasma membrane protein kinase binding regulation of ion transmembrane transport T cell receptor signaling pathway detection of mechanical stimulus involved in sensory perception of pain calcium ion transport into cytosol calcium ion transmembrane transport via high voltage-gated calcium channel calcium ion transmembrane transport protein localization to plasma membrane positive regulation of protein targeting to membrane cellular response to oxygen-glucose deprivation regulation of membrane repolarization during action potential regulation of voltage-gated calcium channel activity negative regulation of voltage-gated calcium channel activity positive regulation of voltage-gated calcium channel activity positive regulation of high voltage-gated calcium channel activity regulation of membrane hyperpolarization L-type voltage-gated calcium channel complex positive regulation of excitatory postsynaptic potential uc007xnc.1 uc007xnc.2 uc007xnc.3 uc007xnc.4 
ENSMUST00000230528.3 Gm22975 ENSMUST00000230528.3 Gm22975 (from geneSymbol) DQ558729 ENSMUST00000230528.1 ENSMUST00000230528.2 uc288unr.1 uc288unr.1 
ENSMUST00000230532.2 Sox10 ENSMUST00000230532.2 Transcription factor that plays a central role in developing and mature glia (PubMed:24204311, PubMed:27532821). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:24204311, PubMed:27532821). Once induced, MYRF cooperates with SOX10 to implement the myelination program (PubMed:24204311). Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). (from UniProt Q04888) AF017182 ENSMUST00000230532.1 O08518 O09141 O54856 P70416 Q04888 SOX10_MOUSE Sox-10 Sox21 uc007wsu.1 uc007wsu.2 uc007wsu.3 uc007wsu.4 Transcription factor that plays a central role in developing and mature glia (PubMed:24204311, PubMed:27532821). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:24204311, PubMed:27532821). Once induced, MYRF cooperates with SOX10 to implement the myelination program (PubMed:24204311). Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). Monomer (PubMed:27532821). Interacts with Armcx3 at the mitochondrial outer membrane surface (PubMed:19304657). Interacts with PAX3 (By similarity). Cytoplasm Nucleus Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side Expressed in oligodendroglia of the spinal tube (at protein level). Expressed in the motor neuron progenitor domain of the spinal tube from 11.5 dpc to postnatal day 6. The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation. Defects in Sox10 are the cause of the mouse mutant dominant megacolon (dom). While dom/+ heterozygous mice display regional deficiencies of neural crest-derived enteric ganglia in the distal colon, dom/dom homozygous animals are embryonic lethal. Sequence=AAB49282.1; Type=Frameshift; Evidence=; Sequence=AAB99738.1; Type=Erroneous initiation; Evidence=; chromatin RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development neural crest cell migration morphogenesis of an epithelium positive regulation of neuroblast proliferation DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane regulation of transcription, DNA-templated transcription elongation from RNA polymerase II promoter peripheral nervous system development transcription factor binding negative regulation of Schwann cell proliferation positive regulation of gene expression oligodendrocyte development positive regulation of gliogenesis membrane central nervous system myelination cell differentiation melanocyte differentiation extrinsic component of mitochondrial outer membrane positive regulation of myelination lacrimal gland development cellular response to drug identical protein binding negative regulation of apoptotic process transcription regulatory region DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell maturation enteric nervous system development digestive tract morphogenesis developmental growth oligodendrocyte differentiation stem cell differentiation morphogenesis of a branching epithelium cellular response to progesterone stimulus negative regulation of canonical Wnt signaling pathway promoter-specific chromatin binding uc007wsu.1 uc007wsu.2 uc007wsu.3 uc007wsu.4 
ENSMUST00000230542.2 Kansl2 ENSMUST00000230542.2 KAT8 regulatory NSL complex subunit 2, transcript variant 7 (from RefSeq NR_153345.1) ENSMUST00000230542.1 KANL2_MOUSE NR_153345 Nsl2 Q3TJH8 Q569W7 Q5XJH6 Q8BQR4 Q8C8F3 Q8C8I6 Q8CEY3 Q99LE5 uc007xmr.1 uc007xmr.2 uc007xmr.3 uc007xmr.4 As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Nucleus Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q8BQR4-1; Sequence=Displayed; Name=2; IsoId=Q8BQR4-2; Sequence=VSP_023275; Name=3; IsoId=Q8BQR4-4; Sequence=VSP_042532, VSP_042533; [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Sequence=AAH03301.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAH92275.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence=; Sequence=BAC32935.1; Type=Frameshift; Evidence=; histone acetyltransferase complex nucleus nucleoplasm cytosol plasma membrane chromatin organization actin cytoskeleton histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) NSL complex histone acetyltransferase activity (H4-K16 specific) uc007xmr.1 uc007xmr.2 uc007xmr.3 uc007xmr.4 
ENSMUST00000230568.2 Prm1 ENSMUST00000230568.2 Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. (from UniProt P02319) AK018980 ENSMUST00000230568.1 HSP1_MOUSE P02319 Prm-1 uc289cjw.1 uc289cjw.2 Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. Cross-linked by interchain disulfide bonds around the DNA- helix. Nucleus. Chromosome. Testis. Phosphorylated by SRPK1. Belongs to the protamine P1 family. nucleosome DNA binding nucleus chromosome nucleus organization multicellular organism development spermatogenesis spermatid development cell differentiation chromosome condensation cytoplasm uc289cjw.1 uc289cjw.2 
ENSMUST00000230580.2 Gm46545 ENSMUST00000230580.2 predicted gene, 46545 (from RefSeq NR_155457.1) ENSMUST00000230580.1 NR_155457 uc289dux.1 uc289dux.2 uc289dux.1 uc289dux.2 
ENSMUST00000230593.2 Gm49534 ENSMUST00000230593.2 Gm49534 (from geneSymbol) AK087425 ENSMUST00000230593.1 uc289cgq.1 uc289cgq.2 uc289cgq.1 uc289cgq.2 
ENSMUST00000230595.2 Gm49522 ENSMUST00000230595.2 Gm49522 (from geneSymbol) BC026207 ENSMUST00000230595.1 uc288zwn.1 uc288zwn.2 uc288zwn.1 uc288zwn.2 
ENSMUST00000230604.2 Tmem249 ENSMUST00000230604.2 transmembrane protein 249 (from RefSeq NM_001378247.1) A0A2R8VHF7 ENSMUST00000230604.1 NM_001378247 TM249_MOUSE Tmem249 uc288zcf.1 uc288zcf.2 Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG2, CATSPERD, CATSPERE, CATSPERZ, C2CD6/CATSPERT, SLCO6C1, TMEM249, TMEM262 and EFCAB9 (PubMed:34225353). HSPA1 may be an additional auxiliary complex member (By similarity). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (PubMed:34225353). The auxiliary CATSPERB, CATSPERG2, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively (PubMed:34225353). SLCO6C1 interacts with CATSPERE and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex (PubMed:34225353). C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane (Probable). Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein Note=Predominantly located in the principal piece of the sperm tail. molecular_function cellular_component biological_process uc288zcf.1 uc288zcf.2 
ENSMUST00000230612.2 A430088P11Rik ENSMUST00000230612.2 RIKEN cDNA A430088P11 gene, transcript variant 2 (from RefSeq NR_045310.1) ENSMUST00000230612.1 NR_045310 uc029stt.1 uc029stt.2 uc029stt.1 uc029stt.2 
ENSMUST00000230614.2 Acap2 ENSMUST00000230614.2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 (from RefSeq NM_030138.2) ACAP2_MOUSE Centb2 ENSMUST00000230614.1 Kiaa0041 NM_030138 Q3UHL4 Q6ZQK5 Q811F3 Q9CTS8 uc007yxb.1 uc007yxb.2 uc007yxb.3 GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid. Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35. Endosome membrane ; Peripheral membrane protein Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q6ZQK5-1; Sequence=Displayed; Name=2 ; IsoId=Q6ZQK5-2; Sequence=VSP_052554; Sequence=BAC97851.1; Type=Erroneous initiation; Evidence=; ruffle GTPase activator activity protein binding endosome endosome membrane membrane Rab GTPase binding actin filament-based process endocytic recycling positive regulation of GTPase activity metal ion binding phosphatidylinositol-3,5-bisphosphate binding cellular response to nerve growth factor stimulus uc007yxb.1 uc007yxb.2 uc007yxb.3 
ENSMUST00000230616.2 Sec14l5 ENSMUST00000230616.2 SEC14-like lipid binding 5, transcript variant 5 (from RefSeq NM_001417651.1) B2RXM5 B2RXM5_MOUSE ENSMUST00000230616.1 NM_001417651 Sec14l5 uc289cft.1 uc289cft.2 molecular_function cellular_component biological_process uc289cft.1 uc289cft.2 
ENSMUST00000230620.2 Gm49512 ENSMUST00000230620.2 Gm49512 (from geneSymbol) ENSMUST00000230620.1 KY467728 uc288zuu.1 uc288zuu.2 uc288zuu.1 uc288zuu.2 
ENSMUST00000230670.2 Gm36245 ENSMUST00000230670.2 Belongs to the CD225/Dispanin family. (from UniProt A0A2R8VHJ9) A0A2R8VHJ9 A0A2R8VHJ9_MOUSE ENSMUST00000230670.1 Gm36245 uc288zil.1 uc288zil.2 Belongs to the CD225/Dispanin family. membrane integral component of membrane uc288zil.1 uc288zil.2 
ENSMUST00000230671.2 D430041D05Rik ENSMUST00000230671.2 RIKEN cDNA D430041D05 gene, transcript variant 3 (from RefSeq NM_001419546.1) A0A2R8VKG2 A0A2R8VKG2_MOUSE D430041D05Rik ENSMUST00000230671.1 NM_001419546 uc289yxs.1 uc289yxs.2 molecular_function cellular_component membrane integral component of membrane uc289yxs.1 uc289yxs.2 
ENSMUST00000230674.2 Gm36618 ENSMUST00000230674.2 Gm36618 (from geneSymbol) ENSMUST00000230674.1 uc289ass.1 uc289ass.2 uc289ass.1 uc289ass.2 
ENSMUST00000230678.3 Gm29904 ENSMUST00000230678.3 predicted gene, 29904, transcript variant 1 (from RefSeq NR_183239.1) ENSMUST00000230678.1 ENSMUST00000230678.2 NR_183239 uc288ygv.1 uc288ygv.2 uc288ygv.3 uc288ygv.1 uc288ygv.2 uc288ygv.3 
ENSMUST00000230686.2 Gm49495 ENSMUST00000230686.2 Gm49495 (from geneSymbol) AK040795 ENSMUST00000230686.1 uc289bij.1 uc289bij.2 uc289bij.1 uc289bij.2 
ENSMUST00000230694.2 Gm35569 ENSMUST00000230694.2 Gm35569 (from geneSymbol) ENSMUST00000230694.1 uc289bmd.1 uc289bmd.2 uc289bmd.1 uc289bmd.2 
ENSMUST00000230697.2 4833412C15Rik ENSMUST00000230697.2 4833412C15Rik (from geneSymbol) AK014684 ENSMUST00000230697.1 uc288zhq.1 uc288zhq.2 uc288zhq.1 uc288zhq.2 
ENSMUST00000230699.2 Gm49422 ENSMUST00000230699.2 Gm49422 (from geneSymbol) ENSMUST00000230699.1 uc288ynm.1 uc288ynm.2 uc288ynm.1 uc288ynm.2 
ENSMUST00000230701.2 Gm10856 ENSMUST00000230701.2 predicted gene 10856 (from RefSeq NR_188829.1) ENSMUST00000230701.1 NR_188829 uc288zsg.1 uc288zsg.2 uc288zsg.1 uc288zsg.2 
ENSMUST00000230703.2 Ubn1 ENSMUST00000230703.2 Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly (By similarity). (from UniProt Q4G0F8) AK147571 ENSMUST00000230703.1 Q3UUZ4 Q4G0F8 Q6P9K7 Q8BNC3 Q9CRM4 Q9CS40 UBN1_MOUSE uc007ybp.1 uc007ybp.2 uc007ybp.3 Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly (By similarity). Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with HIRA (via WD repeat domain); the interaction is direct. Interacts with ASF1A, CEBPA, TJP1, TJP2 and TJP3 (By similarity). Nucleus, nucleoplasm Nucleus, PML body Cell junction, tight junction Note=Localized as a nuclear speckled- like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis (By similarity). Colocalizes with TJP1. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q4G0F8-1; Sequence=Displayed; Name=2; IsoId=Q4G0F8-2; Sequence=VSP_036972; Name=3; IsoId=Q4G0F8-3; Sequence=VSP_036973; Expressed in bile canaliculi in liver, in bronchiolar epithelium in lung and in tubular structures of gland ducts inside the olfactory epithelium and tongue epithelium. Belongs to the ubinuclein family. Sequence=EDK97277.1; Type=Erroneous gene model prediction; Evidence=; DNA binding nucleus nucleoplasm bicellular tight junction chromatin organization DNA replication-independent nucleosome assembly transcription factor binding nuclear body PML body cell junction keratinocyte differentiation uc007ybp.1 uc007ybp.2 uc007ybp.3 
ENSMUST00000230717.2 Gm49552 ENSMUST00000230717.2 Gm49552 (from geneSymbol) ENSMUST00000230717.1 uc056yzp.1 uc056yzp.2 uc056yzp.1 uc056yzp.2 
ENSMUST00000230791.2 Gm49503 ENSMUST00000230791.2 Gm49503 (from geneSymbol) ENSMUST00000230791.1 KY467730 uc289abt.1 uc289abt.2 uc289abt.1 uc289abt.2 
ENSMUST00000230796.2 Gm41341 ENSMUST00000230796.2 Gm41341 (from geneSymbol) ENSMUST00000230796.1 uc288yng.1 uc288yng.2 uc288yng.1 uc288yng.2 
ENSMUST00000230802.2 Gm19782 ENSMUST00000230802.2 predicted gene, 19782 (from RefSeq NR_045071.1) ENSMUST00000230802.1 NR_045071 uc288ynq.1 uc288ynq.2 uc288ynq.1 uc288ynq.2 
ENSMUST00000230810.2 Gm49413 ENSMUST00000230810.2 Gm49413 (from geneSymbol) ENSMUST00000230810.1 LF242707 uc288zcu.1 uc288zcu.2 uc288zcu.1 uc288zcu.2 
ENSMUST00000230828.2 Pmm2 ENSMUST00000230828.2 Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (from UniProt Q9Z2M7) AK134850 ENSMUST00000230828.1 PMM2_MOUSE Q9Z2M7 uc289chl.1 uc289chl.2 Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. Reaction=alpha-D-mannose 1-phosphate = D-mannose 6-phosphate; Xref=Rhea:RHEA:11140, ChEBI:CHEBI:58409, ChEBI:CHEBI:58735; EC=5.4.2.8; Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2. Homodimer. Cytoplasm Belongs to the eukaryotic PMM family. phosphomannomutase activity nucleus cytoplasm cytosol mannose metabolic process protein N-linked glycosylation GDP-mannose biosynthetic process isomerase activity neuronal cell body protein targeting to ER uc289chl.1 uc289chl.2 
ENSMUST00000230853.2 Gm49524 ENSMUST00000230853.2 Gm49524 (from geneSymbol) AK087067 ENSMUST00000230853.1 uc288xvp.1 uc288xvp.2 uc288xvp.1 uc288xvp.2 
ENSMUST00000230860.3 8430426J06Rik ENSMUST00000230860.3 8430426J06Rik (from geneSymbol) BC038155 ENSMUST00000230860.1 ENSMUST00000230860.2 uc007wwj.1 uc007wwj.2 uc007wwj.3 uc007wwj.4 uc007wwj.5 uc007wwj.1 uc007wwj.2 uc007wwj.3 uc007wwj.4 uc007wwj.5 
ENSMUST00000230867.2 Zfp740 ENSMUST00000230867.2 Nucleus (from UniProt A0A2R8W747) A0A2R8W747 A0A2R8W747_MOUSE AK144707 ENSMUST00000230867.1 Zfp740 uc289bqv.1 uc289bqv.2 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding uc289bqv.1 uc289bqv.2 
ENSMUST00000230879.2 ENSMUSG00000121808 ENSMUST00000230879.2 zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1 (from RefSeq NR_175920.1) ENSMUST00000230879.1 NR_175920 uc287wyd.1 uc287wyd.2 uc287wyd.1 uc287wyd.2 
ENSMUST00000230911.3 Gm31342 ENSMUST00000230911.3 Gm31342 (from geneSymbol) ENSMUST00000230911.1 ENSMUST00000230911.2 uc288ymm.1 uc288ymm.2 uc288ymm.3 uc288ymm.1 uc288ymm.2 uc288ymm.3 
ENSMUST00000230919.2 B230214G05Rik ENSMUST00000230919.2 RIKEN cDNA B230214G05 gene (from RefSeq NR_045281.2) ENSMUST00000230919.1 NR_045281 uc029sui.1 uc029sui.2 uc029sui.3 uc029sui.1 uc029sui.2 uc029sui.3 
ENSMUST00000230927.2 Gm30371 ENSMUST00000230927.2 Gm30371 (from geneSymbol) BC072646 ENSMUST00000230927.1 uc289cif.1 uc289cif.2 uc289cif.1 uc289cif.2 
ENSMUST00000230931.2 Nudt16l1 ENSMUST00000230931.2 nudix hydrolase 16 like 1, transcript variant 1 (from RefSeq NM_025839.4) ENSMUST00000230931.1 NM_025839 Nudt16l1 Q3TW47 Q8R039 Q8R3D9 Q8VHN8 Q9CR90 Q9D8M0 Sdos TIRR_MOUSE Tirr uc029svr.1 uc029svr.2 uc029svr.3 uc029svr.4 Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs). Binds U8 snoRNA. Homodimer (PubMed:26100207). Interacts with TP53BP1 (via the Tudor-like domain); interaction is abolished following DNA damage and TP53BP1 phosphorylation by ATM (By similarity). Interacts (via the cytoplasmic part) with SDC4 (PubMed:11805099). Interacts with TGFB1I1 and PXN (PubMed:11805099). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8VHN8-1; Sequence=Displayed; Name=2; IsoId=Q8VHN8-2; Sequence=VSP_014279; Name=3; IsoId=Q8VHN8-3; Sequence=VSP_014277, VSP_014278; Belongs to the Nudix hydrolase family. TIRR subfamily. Although strongly related to the nudix NUDT16 protein, lacks the Nudix box and is therefore not related to the rest of the family. Lacks a number of residues which are necessary for hydrolase activity and does not play a role in U8 snoRNA decapping activity. RNA binding nucleus dephosphorylation hydrolase activity snoRNA binding RNA phosphodiester bond hydrolysis, endonucleolytic negative regulation of double-strand break repair via nonhomologous end joining mRNA catabolic process snoRNA catabolic process protein homodimerization activity m7G(5')pppN diphosphatase activity nucleotide phosphatase activity, acting on free nucleotides phosphodiesterase decapping endonuclease activity uc029svr.1 uc029svr.2 uc029svr.3 uc029svr.4 
ENSMUST00000230936.2 Gm46563 ENSMUST00000230936.2 Gm46563 (from geneSymbol) ENSMUST00000230936.1 uc289cjx.1 uc289cjx.2 uc289cjx.1 uc289cjx.2 
ENSMUST00000230939.2 Gm49553 ENSMUST00000230939.2 Gm49553 (from geneSymbol) AK084480 ENSMUST00000230939.1 uc288zut.1 uc288zut.2 uc288zut.1 uc288zut.2 
ENSMUST00000230941.3 Gm36002 ENSMUST00000230941.3 Gm36002 (from geneSymbol) ENSMUST00000230941.1 ENSMUST00000230941.2 uc289wpl.1 uc289wpl.2 uc289wpl.3 uc289wpl.1 uc289wpl.2 uc289wpl.3 
ENSMUST00000230948.2 Phf20l1 ENSMUST00000230948.2 PHD finger protein 20-like 1, transcript variant 8 (from RefSeq NM_001418892.1) A0A2R8VHV1 A0A2R8VHV1_MOUSE ENSMUST00000230948.1 NM_001418892 Phf20l1 uc288yld.1 uc288yld.2 Nucleus nucleus regulation of transcription, DNA-templated metal ion binding uc288yld.1 uc288yld.2 
ENSMUST00000230977.2 Slc39a4 ENSMUST00000230977.2 solute carrier family 39 (zinc transporter), member 4 (from RefSeq NM_028064.3) ENSMUST00000230977.1 NM_028064 Q78IQ7 Q8CHL4 S39A4_MOUSE Zip4 uc007wlb.1 uc007wlb.2 uc007wlb.3 Selective transporter that mediates the uptake of Zn(2+) (PubMed:14709598, PubMed:14612438, PubMed:12801924). Plays an essential role for dietary zinc uptake from small intestine (PubMed:12801924). The Zn(2+) uniporter activity is regulated by zinc availability (By similarity). Exhibits also polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:12801924). Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence= Kinetic parameters: KM=1.7 uM for Zn(2+) ; KM=1.6 uM for Zn(2+) ; Vmax=8.9 pmol/min/mg enzyme with Zn(2+) as substrate ; Vmax=13.1 pmol/min/mg enzyme with Zn(2+) as substrate ; Homodimer (PubMed:30593504). Homodimerization is mediated by the transmembrane domain (By similarity). Cell membrane ulti-pass membrane protein Recycling endosome membrane ; Multi-pass membrane protein Apical cell membrane ulti-pass membrane protein Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to Zn(2+) availability. Zn(2+) deficiency promotes accumulation of SLC39A4 on the surface membrane, whereas high extracellular Zn(2+) levels induce internalization of SLC39A4, but also trigger drastic removal of cellular SLC39A4 via proteasomal and lysosomal degradation pathways (PubMed:14612438, PubMed:18020946, PubMed:30593504). Translocates to the apical membrane during zinc deficiency (PubMed:12801924, PubMed:18020946). Expressed on the apical surface of the intestinal wall (PubMed:18936158). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=Q78IQ7-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q78IQ7-2; Sequence=VSP_015913, VSP_015914; Highly expressed in the small intestine and embryonic visceral yolk sac. Weakly expressed in the stomach and liver. Up-regulated under conditions of dietary zinc deficiency. Down-regulated under conditions of dietary zinc excess. The two metal binding sites M1 and M2 that are halfway through the membrane form a binuclear metal center. M1 is essential to Zn(2+) transport, while the other, M2 appears to have an auxiliary role presumably by acting as an additional transport site that can modulate the properties of the primary transport site. The binuclear metal center plays a key role in Zn(2+) sensing. The extracellular N-terminal ectodomain is cleaved when cells are Zn(2+) deficient, N-terminally cleaved SLC39A4 is then internalized faster. Under excess Zn(2+) conditions, SLC39A4 on the cell surface is rapidly endocytosed, ubiquitinated, and degraded. N-glycosylated. Knockout mice die in utero during early development. Mice heterozygous for a null allele exhibit developmental defects similar to the teratology of zinc deficiency (PubMed:17483098). Slc39a4-intestine knockout mice reveal that total zinc is dramatically and rapidly decreased in these organs whereas iron, manganese, and copper slowly accumulated to high levels in the liver as the disease progressed. Defect in zinc uptake are followed by a switch from anabolic to catabolic metabolism in the mouse leading to dramatic weight loss, dyshomeostasis of several essential metals and ultimately lethality in the absence of excess dietary zinc (PubMed:22737083). Belongs to the ZIP transporter (TC 2.A.5) family. zinc ion transmembrane transporter activity endosome plasma membrane integral component of plasma membrane ion transport zinc II ion transport cellular zinc ion homeostasis signal transduction membrane integral component of membrane apical plasma membrane metal ion transport cytoplasmic vesicle cellular response to zinc ion starvation metal ion transmembrane transporter activity recycling endosome membrane transmembrane transport zinc II ion transmembrane transport zinc II ion transmembrane import uc007wlb.1 uc007wlb.2 uc007wlb.3 
ENSMUST00000230979.2 Apol9b ENSMUST00000230979.2 apolipoprotein L 9b, transcript variant 2 (from RefSeq NM_173743.4) Apol9b D3Z501 ENSMUST00000230979.1 NM_173743 Q8C7I4 Q8C7I4_MOUSE uc007wny.1 uc007wny.2 uc007wny.3 uc007wny.4 Belongs to the apolipoprotein L family. cellular_component extracellular region lipid transport biological_process lipid binding lipoprotein metabolic process uc007wny.1 uc007wny.2 uc007wny.3 uc007wny.4 
ENSMUST00000230986.2 Gm49437 ENSMUST00000230986.2 Gm49437 (from geneSymbol) ENSMUST00000230986.1 uc289bcv.1 uc289bcv.2 uc289bcv.1 uc289bcv.2 
ENSMUST00000230993.2 Gm49411 ENSMUST00000230993.2 Gm49411 (from geneSymbol) AK158365 ENSMUST00000230993.1 uc288zht.1 uc288zht.2 uc288zht.1 uc288zht.2 
ENSMUST00000231018.2 Gm49507 ENSMUST00000231018.2 Gm49507 (from geneSymbol) ENSMUST00000231018.1 uc289byz.1 uc289byz.2 uc289byz.1 uc289byz.2 
ENSMUST00000231019.2 Gm33432 ENSMUST00000231019.2 Gm33432 (from geneSymbol) AK142623 ENSMUST00000231019.1 uc289aiq.1 uc289aiq.2 uc289aiq.1 uc289aiq.2 
ENSMUST00000231034.2 4930588D02Rik ENSMUST00000231034.2 4930588D02Rik (from geneSymbol) AK019831 ENSMUST00000231034.1 uc288ztu.1 uc288ztu.2 uc288ztu.1 uc288ztu.2 
ENSMUST00000231051.2 Gm41409 ENSMUST00000231051.2 Gm41409 (from geneSymbol) AK163292 ENSMUST00000231051.1 uc007xyr.1 uc007xyr.2 uc007xyr.3 uc007xyr.1 uc007xyr.2 uc007xyr.3 
ENSMUST00000231068.2 Gm49482 ENSMUST00000231068.2 Gm49482 (from geneSymbol) ENSMUST00000231068.1 uc289bxh.1 uc289bxh.2 uc289bxh.1 uc289bxh.2 
ENSMUST00000231096.2 Gm49496 ENSMUST00000231096.2 Functions as a GC-rich promoter-specific transactivating transcription factor. (from UniProt A0A2R8W6M1) A0A2R8W6M1 A0A2R8W6M1_MOUSE AK136894 ENSMUST00000231096.1 Gm49496 uc288pxg.1 uc288pxg.2 Functions as a GC-rich promoter-specific transactivating transcription factor. Nucleus Belongs to the vasculin family. transcription factor activity, sequence-specific DNA binding nucleus transcription, DNA-templated positive regulation of transcription, DNA-templated uc288pxg.1 uc288pxg.2 
ENSMUST00000231106.4 Gm49463 ENSMUST00000231106.4 Gm49463 (from geneSymbol) ENSMUST00000231106.1 ENSMUST00000231106.2 ENSMUST00000231106.3 LF200407 uc289agm.1 uc289agm.2 uc289agm.3 uc289agm.4 uc289agm.1 uc289agm.2 uc289agm.3 uc289agm.4 
ENSMUST00000231124.2 Gm49513 ENSMUST00000231124.2 Gm49513 (from geneSymbol) AK003990 ENSMUST00000231124.1 uc289air.1 uc289air.2 uc289air.1 uc289air.2 
ENSMUST00000231164.2 4930504C09Rik ENSMUST00000231164.2 RIKEN cDNA 4930504C09 gene (from RefSeq NR_130983.1) ENSMUST00000231164.1 NR_130983 uc056yza.1 uc056yza.2 uc056yza.3 uc056yza.1 uc056yza.2 uc056yza.3 
ENSMUST00000231165.2 Nfam1 ENSMUST00000231165.2 Nfat activating molecule with ITAM motif 1, transcript variant 2 (from RefSeq NM_001271412.1) Cnaip ENSMUST00000231165.1 NFAM1_MOUSE NM_001271412 Q3UAX8 Q8R4V1 Q9D5Z3 uc007wzv.1 uc007wzv.2 uc007wzv.3 uc007wzv.4 May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters (By similarity). May be involved in the regulation of B-cell, but not T-cell, development. No direct interaction with the B-cell antigen receptor (BCR). Interacts with SYK; probably involved in BCR signaling. Interacts with ZAP70. Cell membrane ; Single-pass type I membrane protein Note=Partially recruited to lipid rafts upon BCR stimulation. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R4V1-1; Sequence=Displayed; Name=2; IsoId=Q8R4V1-2; Sequence=VSP_008044; Name=3; IsoId=Q8R4V1-3; Sequence=VSP_008043; Highly expressed in the spleen, expressed by both B- and CD4+ and CD8+ T-cells, as well as non-T- and non-B-cells, including macrophages and neutrophils. Expressed at low levels, if any, in non-immune tissue. Highest expression in pro-B-cells decreases with B-cell differentiation. The ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions. The phosphorylated ITAM domain binds ZAP70 and SYK. N-glycosylated. positive regulation of cytokine production transmembrane signaling receptor activity plasma membrane signal transduction cell surface membrane integral component of membrane B cell differentiation intracellular signal transduction membrane raft regulation of B cell differentiation B cell receptor signaling pathway positive regulation of B cell receptor signaling pathway positive regulation of sequence-specific DNA binding transcription factor activity uc007wzv.1 uc007wzv.2 uc007wzv.3 uc007wzv.4 
ENSMUST00000231220.2 Gm41496 ENSMUST00000231220.2 Gm41496 (from geneSymbol) AK087806 ENSMUST00000231220.1 uc007zyv.1 uc007zyv.2 uc007zyv.3 uc007zyv.1 uc007zyv.2 uc007zyv.3 
ENSMUST00000231240.2 A630036G19Rik ENSMUST00000231240.2 A630036G19Rik (from geneSymbol) AK041773 ENSMUST00000231240.1 uc289fmu.1 uc289fmu.2 uc289fmu.1 uc289fmu.2 
ENSMUST00000231252.2 Fst ENSMUST00000231252.2 follistatin, transcript variant 2 (from RefSeq NM_008046.3) A6H6P0 ENSMUST00000231252.1 FST_MOUSE Fst NM_008046 P47931 uc007rxn.1 uc007rxn.2 uc007rxn.3 uc007rxn.4 The protein encoded by this gene binds to and negatively regulates activin, as well as other members of the transforming growth factor beta family, and acts to prevent uncontrolled cellular proliferation. This protein also contains a heparin-binding sequence. It is expressed in many of the tissues in which activin is synthesized and is thought to clear activin from the circulation by attachment to the cell surface. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms, including FST315 and FST288, that differ at their C-terminus. Another isoform, FST303 is thought to be produced by proteolytic cleavage of FST315. These isoforms differ in their localization and in their ability to bind heparin. While FST315 is a circulating protein, FST288 is tissue-bound, and FST303 is gonad-specific. While deletion of all isoforms results in embryonic lethality, expression of just FST288 is sufficient for embryonic development, but the resultant mice have fertility defects. [provided by RefSeq, Aug 2014]. Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). Monomer. Secreted. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P47931-1; Sequence=Displayed; Name=2; IsoId=P47931-2; Sequence=VSP_060082; Embryonic expression first occurs in the primitive streak, followed by expression in head mesoderm, somites, and specific rhombomeres of the hindbrain, and later in midbrain and diencephalon. No expression is seen in the node or notochord. Induces muscle hypertrophy when injected into the tibialis anterior muscle with reduced response in older mice. negative regulation of transcription from RNA polymerase II promoter skeletal system development hematopoietic progenitor cell differentiation extracellular region extracellular space nucleus cytoplasm multicellular organism development gamete generation pattern specification process female gonad development cell differentiation BMP signaling pathway regulation of BMP signaling pathway hair follicle morphogenesis negative regulation of activin receptor signaling pathway activin receptor antagonist activity odontogenesis of dentin-containing tooth heparan sulfate proteoglycan binding keratinocyte proliferation negative regulation of cell differentiation activin binding positive regulation of hair follicle development uc007rxn.1 uc007rxn.2 uc007rxn.3 uc007rxn.4 
ENSMUST00000231277.3 Gm49595 ENSMUST00000231277.3 Gm49595 (from geneSymbol) ENSMUST00000231277.1 ENSMUST00000231277.2 uc289cth.1 uc289cth.2 uc289cth.3 uc289cth.1 uc289cth.2 uc289cth.3 
ENSMUST00000231309.2 Gm49696 ENSMUST00000231309.2 Gm49696 (from geneSymbol) ENSMUST00000231309.1 uc289fwe.1 uc289fwe.2 uc289fwe.1 uc289fwe.2 
ENSMUST00000231314.2 4833419O12Rik ENSMUST00000231314.2 4833419O12Rik (from geneSymbol) AK014730 ENSMUST00000231314.1 uc289dob.1 uc289dob.2 uc289dob.1 uc289dob.2 
ENSMUST00000231324.2 4930542D17Rik ENSMUST00000231324.2 RIKEN cDNA 4930542D17 gene (from RefSeq NR_040566.1) ENSMUST00000231324.1 NR_040566 uc029sxn.1 uc029sxn.2 uc029sxn.1 uc029sxn.2 
ENSMUST00000231328.2 Ahsg ENSMUST00000231328.2 Secreted (from UniProt A0A338P7H5) A0A338P7H5 A0A338P7H5_MOUSE Ahsg BC019822 ENSMUST00000231328.1 uc289drw.1 uc289drw.2 Secreted cysteine-type endopeptidase inhibitor activity extracellular space negative regulation of endopeptidase activity uc289drw.1 uc289drw.2 
ENSMUST00000231330.2 Gm35455 ENSMUST00000231330.2 Gm35455 (from geneSymbol) ENSMUST00000231330.1 uc289hfv.1 uc289hfv.2 uc289hfv.1 uc289hfv.2 
ENSMUST00000231335.2 Gm49601 ENSMUST00000231335.2 Filament-forming cytoskeletal GTPase. (from UniProt A0A338P6R8) A0A338P6R8 A0A338P6R8_MOUSE BC141073 ENSMUST00000231335.1 Gm49601 uc289dey.1 uc289dey.2 Filament-forming cytoskeletal GTPase. Septins polymerize into heterooligomeric protein complexes that form filaments. Cytoplasm, cytoskeleton Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. nucleotide binding GTP binding synaptic vesicle regulation of exocytosis uc289dey.1 uc289dey.2 
ENSMUST00000231339.2 Ccdc171 ENSMUST00000231339.2 coiled-coil domain containing 171, transcript variant 2 (from RefSeq NM_001355549.1) CC171_MOUSE E9Q1U1 ENSMUST00000231339.1 NM_001355549 Q8BLX2 uc290nng.1 uc290nng.2 Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=E9Q1U1-1; Sequence=Displayed; Name=2; IsoId=E9Q1U1-2; Sequence=VSP_043769; molecular_function cellular_component biological_process uc290nng.1 uc290nng.2 
ENSMUST00000231355.3 Gm5165 ENSMUST00000231355.3 Gm5165 (from geneSymbol) ENSMUST00000231355.1 ENSMUST00000231355.2 uc289hii.1 uc289hii.2 uc289hii.3 uc289hii.1 uc289hii.2 uc289hii.3 
ENSMUST00000231360.2 Senp5 ENSMUST00000231360.2 SUMO/sentrin specific peptidase 5, transcript variant 1 (from RefSeq NM_177103.4) ENSMUST00000231360.1 NM_177103 Q3ZTK4 Q6NXL6 Q8BXW0 SENP5_MOUSE Smt3ip3 uc007yya.1 uc007yya.2 uc007yya.3 uc007yya.4 Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Interacts with CCAR2. Nucleus, nucleolus Belongs to the peptidase C48 family. nucleus nucleolus proteolysis cell cycle peptidase activity cysteine-type peptidase activity hydrolase activity protein desumoylation ubiquitin-like protein-specific protease activity cell division uc007yya.1 uc007yya.2 uc007yya.3 uc007yya.4 
ENSMUST00000231369.2 Ccdc188 ENSMUST00000231369.2 coiled-coil domain containing 188 (from RefSeq NM_001370887.1) A0A338P6G2 A0A338P6G2_MOUSE Ccdc188 ENSMUST00000231369.1 NM_001370887 uc289dbq.1 uc289dbq.2 molecular_function cellular_component biological_process uc289dbq.1 uc289dbq.2 
ENSMUST00000231375.2 Qser1 ENSMUST00000231375.2 glutamine and serine rich 1 (from RefSeq NM_001123327.3) A0A338P6K9 A2BIE1 ENSMUST00000231375.1 NM_001123327 Q3UR75 QSER1_MOUSE Qser1 uc289yyw.1 uc289yyw.2 Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. Interacts with TET1. Chromosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A0A338P6K9-1; Sequence=Displayed; Name=2; IsoId=A0A338P6K9-2; Sequence=VSP_061204; molecular_function cellular_component biological_process uc289yyw.1 uc289yyw.2 
ENSMUST00000231384.2 Gm33255 ENSMUST00000231384.2 Gm33255 (from geneSymbol) AK135250 ENSMUST00000231384.1 uc289fvh.1 uc289fvh.2 uc289fvh.1 uc289fvh.2 
ENSMUST00000231385.2 Gm49769 ENSMUST00000231385.2 Gm49769 (from geneSymbol) AK179918 ENSMUST00000231385.1 uc288fge.1 uc288fge.2 uc288fge.1 uc288fge.2 
ENSMUST00000231393.2 2210009P08Rik ENSMUST00000231393.2 2210009P08Rik (from geneSymbol) AK008691 ENSMUST00000231393.1 uc289gny.1 uc289gny.2 uc289gny.1 uc289gny.2 
ENSMUST00000231397.2 Gm49630 ENSMUST00000231397.2 Membrane ; Multi- pass membrane protein (from UniProt A0A338P6P3) A0A338P6P3 A0A338P6P3_MOUSE AM690745 ENSMUST00000231397.1 Gm49630 uc289guy.1 uc289guy.2 Membrane ; Multi- pass membrane protein Belongs to the unc-93 family. membrane integral component of membrane uc289guy.1 uc289guy.2 
ENSMUST00000231407.4 6330408M09Rik ENSMUST00000231407.4 6330408M09Rik (from geneSymbol) ENSMUST00000231407.1 ENSMUST00000231407.2 ENSMUST00000231407.3 uc289dtt.1 uc289dtt.2 uc289dtt.3 uc289dtt.4 uc289dtt.1 uc289dtt.2 uc289dtt.3 uc289dtt.4 
ENSMUST00000231415.2 Dlg4 ENSMUST00000231415.2 discs large MAGUK scaffold protein 4, transcript variant 3 (from RefSeq NM_001370671.1) DLG4_MOUSE Dlg4 Dlgh4 ENSMUST00000231415.1 NM_001370671 Psd95 Q5NCV5 Q5NCV6 Q5NCV7 Q62108 Q91WJ1 uc007jtq.1 uc007jtq.2 uc007jtq.3 uc007jtq.4 uc007jtq.5 Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins (PubMed:15358775, PubMed:9853749). Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (Probable). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (By similarity). Interacts through its PDZ domains with ANO2 and NETO1 (PubMed:19474308, PubMed:19243221). Interacts with KCNJ4 (By similarity). Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D (By similarity). Interacts with ERBB4 (By similarity). Interacts with KCNA1, KCNA2, KCNA3 and KCNA4 (By similarity). Interacts with SYNGAP1 (By similarity). Interacts with ASIC3 (By similarity). Interacts with CXADR (By similarity). Interacts with KCND2 (By similarity). Interacts with SEMA4C (PubMed:11134026). Interacts with LRRC4 and LRRC4B (PubMed:16980967). Interacts through its first PDZ domain with GRIK2 and CRIPT (By similarity). Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C- terminus of CAPON (By similarity). Interacts through its third PDZ domain with NLGN1 and CRIPT, and probably with NLGN2 and NLGN3 (By similarity). Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A, BEGAIN, SIPA1L1 and KIF13B (By similarity). Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK (By similarity). Interacts with ADR1B (PubMed:15358775). Interacts with ANKS1B and PRR7 (By similarity). May interact with HTR2A (PubMed:14988405). Interacts with ADAM22, KLHL17 and LGI1 (PubMed:20089912) (By similarity). Interacts with FRMPD4 (via C-terminus) (By similarity). Interacts with LRFN1, LRFN2 and LRFN4 (PubMed:16828986). Interacts (via N-terminal tandem pair of PDZ domains) with GPER1 (via C-terminus tail motif); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner (By similarity). Interacts (via N-terminus tandem pair of PDZ domains) with NOS1 (via N-terminal domain) (By similarity). Interacts with SHANK3 (PubMed:24153177). Interacts with KCNJ4 (PubMed:11997254). Interacts with GPR85 (By similarity). Interacts with CACNG2 and MPP2 (via the SH3-Guanylate kinase-like sub-module) (By similarity). Interacts with ADGRB1 (By similarity). Found in a complex with PRR7 and GRIN1 (By similarity). Interacts (via PDZ3 domain and to lesser degree via PDZ2 domain) with PRR7 (By similarity). Component of the postsynaptic hippocampal AMPA-type glutamate receptor (AMPAR) complex, at least composed of pore forming AMPAR subunits GRIA1, GRIA2 and GRIA3 and AMPAR auxiliary proteins SHISA6 and SHISA7. Interacts (via its first two PDZ domains) with SHISA6 and SHISA7 (via PDZ-binding motif); the interaction is direct (PubMed:26931375, PubMed:29199957). Interacts (via PDZ domain 2) with SEMA4F (via PDZ-binding motif); this interaction may promote translocation of DLG4/SAP90 to the membrane (PubMed:11483650). Interacts with RPH3A and GRIN2A; this ternary complex regulates NMDA receptor composition at postsynaptic membranes (By similarity). Interacts with ABR and BCR (By similarity). Interacts with DGKI (via PDZ-binding motif); controls the localization of DGKI to the synapse (By similarity). Interacts with C9orf72, SMCR8 and RAB39B (PubMed:31651360). Interacts with ZDHHC5 (PubMed:20178993). Interacts with PTEN (via PDZ domain-binding motif); the interaction is induced by NMDA and is required for PTEN location at postsynaptic density (By similarity). Q62108; Q8K4G5: Ablim1; NbExp=5; IntAct=EBI-300895, EBI-2307994; Q62108; P12023: App; NbExp=4; IntAct=EBI-300895, EBI-78814; Q62108; Q9WV31: Arc; NbExp=7; IntAct=EBI-300895, EBI-397779; Q62108; Q8BKX1: Baiap2; NbExp=4; IntAct=EBI-300895, EBI-771498; Q62108; P11798: Camk2a; NbExp=4; IntAct=EBI-300895, EBI-400384; Q62108; P35347: Crhr1; NbExp=7; IntAct=EBI-300895, EBI-16879653; Q62108; Q811D0: Dlg1; NbExp=4; IntAct=EBI-300895, EBI-514290; Q62108; Q91XM9: Dlg2; NbExp=6; IntAct=EBI-300895, EBI-400138; Q62108; P70175: Dlg3; NbExp=4; IntAct=EBI-300895, EBI-396969; Q62108; Q61090: Fzd7; NbExp=4; IntAct=EBI-300895, EBI-8473104; Q62108; Q9R111: Gda; NbExp=6; IntAct=EBI-300895, EBI-2308876; Q62108; P35438: Grin1; NbExp=13; IntAct=EBI-300895, EBI-400084; Q62108; P35436: Grin2a; NbExp=15; IntAct=EBI-300895, EBI-400115; Q62108; Q01097: Grin2b; NbExp=19; IntAct=EBI-300895, EBI-400125; Q62108; Q61423: Kcna4; NbExp=3; IntAct=EBI-300895, EBI-2309633; Q62108; Q80TG9: Lrfn2; NbExp=3; IntAct=EBI-300895, EBI-877092; Q62108; Q91ZX7: Lrp1; NbExp=4; IntAct=EBI-300895, EBI-300955; Q62108; A2ARV4: Lrp2; NbExp=2; IntAct=EBI-300895, EBI-300875; Q62108; Q924X6: Lrp8; NbExp=3; IntAct=EBI-300895, EBI-432319; Q62108; P63085: Mapk1; NbExp=4; IntAct=EBI-300895, EBI-397697; Q62108; P23804: Mdm2; NbExp=3; IntAct=EBI-300895, EBI-641788; Q62108; Q8R4I7: Neto1; NbExp=7; IntAct=EBI-300895, EBI-2314926; Q62108; Q810U4: Nrcam; NbExp=2; IntAct=EBI-300895, EBI-8321816; Q62108; P46460: Nsf; NbExp=5; IntAct=EBI-300895, EBI-398006; Q62108; P15209: Ntrk2; NbExp=4; IntAct=EBI-300895, EBI-309647; Q62108; Q80TE2: Pcdh10; NbExp=4; IntAct=EBI-300895, EBI-6661550; Q62108; Q14B62: ptchd1; NbExp=8; IntAct=EBI-300895, EBI-27105784; Q62108; P63001: Rac1; NbExp=3; IntAct=EBI-300895, EBI-413646; Q62108; Q8R550: Sh3kbp1; NbExp=3; IntAct=EBI-300895, EBI-642709; Q62108; P30873: Sstr1; NbExp=3; IntAct=EBI-300895, EBI-7665262; Q62108; P49660: Sstr4; NbExp=3; IntAct=EBI-300895, EBI-7665342; Q62108; Q9WVI4: Gucy1a2; Xeno; NbExp=3; IntAct=EBI-300895, EBI-7665590; Cell membrane ; Lipid-anchor ; Cytoplasmic side Postsynaptic density napse Cytoplasm Cell projection, axon Cell projection, dendritic spine Cell projection, dendrite Presynapse Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=PSD95-alpha; IsoId=Q62108-1; Sequence=Displayed; Name=2; Synonyms=PSD95-beta; IsoId=Q62108-2; Sequence=VSP_014930; Name=3; IsoId=Q62108-3; Sequence=VSP_014931; Highly expressed in CA1 stratum oriens and stratum radiatum hippocampal neurons (PubMed:26931375). Expressed in the outer plexiform layer of the retina of the eye (at protein level) (PubMed:28334377). The PDZ domain 3 mediates interaction with ADR1B. The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density. Palmitoylated. Palmitoylation is required for targeting to postsynaptic density, plasma membrane and synapses. Palmitoylation by ZDHHC2 occurs when the synaptic activity decreases and induces DLG4 synaptic clustering. Palmitoylation by ZDHHC15 regulates trafficking to the postsynaptic density and function in synaptogenesis. Palmitoylation may play a role in glutamate receptor GRIA1 synapse clustering. Depalmitoylated by ABHD17A and ABHD17B and to a lesser extent by ABHD17C, ABHD12, ABHD13, LYPLA1 and LYPLA2. Undergoes rapid synaptic palmitoylation/depalmitoylation cycles during neuronal development which slow down in mature neurons. Ubiquitinated by MDM2 in response to NMDA receptor activation, leading to proteasome-mediated degradation of DLG4 which is required for AMPA receptor endocytosis. Mice with a stop codon in the third PDZ domain have impaired spatial learning. NMDA-mediated synaptic plasticity is lost even though receptor levels and localization are unchanged. Long- term potentiation of synaptic transmission is enhanced due to minimal long-term depression. Belongs to the MAGUK family. negative regulation of receptor internalization receptor binding frizzled binding structural molecule activity protein binding cytoplasm endoplasmic reticulum plasma membrane cell-cell junction positive regulation of cytosolic calcium ion concentration chemical synaptic transmission locomotory behavior synaptic vesicle protein C-terminus binding postsynaptic density membrane synaptic vesicle maturation immunoglobulin binding kinesin binding kinase binding protein kinase binding protein phosphatase binding cell junction PDZ domain binding axon dendrite cortical cytoskeleton extrinsic component of cytoplasmic side of plasma membrane neuromuscular junction beta-1 adrenergic receptor binding beta-2 adrenergic receptor binding D1 dopamine receptor binding P2Y1 nucleotide receptor binding AMPA glutamate receptor complex dendrite cytoplasm acetylcholine receptor binding social behavior glutamate receptor binding ionotropic glutamate receptor binding protein localization to synapse locomotory exploration behavior cellular response to potassium ion neurexin family protein binding response to cocaine cell projection neuron projection receptor clustering dendritic spine juxtaparanode region of axon cerebellar mossy fiber neuron projection terminus neuron spine macromolecular complex binding establishment of protein localization synapse postsynaptic membrane regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity positive regulation of synaptic transmission neuromuscular process controlling balance excitatory synapse dendritic spine morphogenesis positive regulation of protein tyrosine kinase activity macromolecular complex assembly vocalization behavior cell periphery synaptic membrane dendritic spine organization neuroligin family protein binding scaffold protein binding AMPA glutamate receptor clustering receptor localization to synapse cell-cell adhesion postsynapse postsynaptic density membrane structural constituent of postsynaptic density postsynaptic neurotransmitter receptor diffusion trapping glutamatergic synapse anchored component of postsynaptic density membrane maintenance of postsynaptic density structure neurotransmitter receptor localization to postsynaptic specialization membrane regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential regulation of grooming behavior voltage-gated potassium channel complex ionotropic glutamate receptor complex uc007jtq.1 uc007jtq.2 uc007jtq.3 uc007jtq.4 uc007jtq.5 
ENSMUST00000231421.2 Gm49763 ENSMUST00000231421.2 Gm49763 (from geneSymbol) ENSMUST00000231421.1 uc288opc.1 uc288opc.2 uc288opc.1 uc288opc.2 
ENSMUST00000231427.2 Gm49710 ENSMUST00000231427.2 Gm49710 (from geneSymbol) ENSMUST00000231427.1 uc289fxf.1 uc289fxf.2 uc289fxf.1 uc289fxf.2 
ENSMUST00000231428.2 Gm49764 ENSMUST00000231428.2 Gm49764 (from geneSymbol) ENSMUST00000231428.1 uc288ffn.1 uc288ffn.2 uc288ffn.1 uc288ffn.2 
ENSMUST00000231433.2 Msantd5l ENSMUST00000231433.2 Msantd5l (from geneSymbol) A0A338P6D5 A0A338P6D5_MOUSE AK154967 BC049762 ENSMUST00000231433.1 Msantd5l uc287xys.1 uc287xys.2 molecular_function cellular_component biological_process uc287xys.1 uc287xys.2 
ENSMUST00000231442.2 Gm49576 ENSMUST00000231442.2 Gm49576 (from geneSymbol) ENSMUST00000231442.1 uc289fdx.1 uc289fdx.2 uc289fdx.1 uc289fdx.2 
ENSMUST00000231449.2 Cdr1os ENSMUST00000231449.2 cerebellar degeneration related antigen 1, opposite strand, transcript variant 2 (from RefSeq NR_173099.1) ENSMUST00000231449.1 NR_173099 uc292ojr.1 uc292ojr.2 uc292ojr.1 uc292ojr.2 
ENSMUST00000231454.2 Gm49750 ENSMUST00000231454.2 Gm49750 (from geneSymbol) AK145012 ENSMUST00000231454.1 uc289doo.1 uc289doo.2 uc289doo.1 uc289doo.2 
ENSMUST00000231458.2 Gm49653 ENSMUST00000231458.2 Gm49653 (from geneSymbol) AK157549 ENSMUST00000231458.1 uc289elq.1 uc289elq.2 uc289elq.1 uc289elq.2 
ENSMUST00000231464.2 Gm49603 ENSMUST00000231464.2 Gm49603 (from geneSymbol) AK030200 ENSMUST00000231464.1 uc056zcs.1 uc056zcs.2 uc056zcs.1 uc056zcs.2 
ENSMUST00000231483.2 Gm49774 ENSMUST00000231483.2 Gm49774 (from geneSymbol) ENSMUST00000231483.1 LF200984 uc289isz.1 uc289isz.2 uc289isz.1 uc289isz.2 
ENSMUST00000231503.2 Gm30881 ENSMUST00000231503.2 Gm30881 (from geneSymbol) ENSMUST00000231503.1 uc289ggs.1 uc289ggs.2 uc289ggs.1 uc289ggs.2 
ENSMUST00000231511.2 Gm49736 ENSMUST00000231511.2 Gm49736 (from geneSymbol) ENSMUST00000231511.1 uc289dzy.1 uc289dzy.2 uc289dzy.1 uc289dzy.2 
ENSMUST00000231521.3 Mirt2 ENSMUST00000231521.3 myocardial infraction associated transcript 2 (from RefSeq NR_045747.1) ENSMUST00000231521.1 ENSMUST00000231521.2 NR_045747 uc029ssh.1 uc029ssh.2 uc029ssh.3 uc029ssh.4 uc029ssh.1 uc029ssh.2 uc029ssh.3 uc029ssh.4 
ENSMUST00000231527.2 Gm49642 ENSMUST00000231527.2 Gm49642 (from geneSymbol) AK046687 ENSMUST00000231527.1 uc289gkh.1 uc289gkh.2 uc289gkh.1 uc289gkh.2 
ENSMUST00000231532.3 Gm10823 ENSMUST00000231532.3 predicted gene 10823 (from RefSeq NR_033475.1) ENSMUST00000231532.1 ENSMUST00000231532.2 NR_033475 uc012adw.1 uc012adw.2 uc012adw.3 uc012adw.1 uc012adw.2 uc012adw.3 
ENSMUST00000231533.2 Gm49659 ENSMUST00000231533.2 Gm49659 (from geneSymbol) AK051820 ENSMUST00000231533.1 uc289fmn.1 uc289fmn.2 uc289fmn.1 uc289fmn.2 
ENSMUST00000231541.3 4930567J20Rik ENSMUST00000231541.3 4930567J20Rik (from geneSymbol) AK019789 ENSMUST00000231541.1 ENSMUST00000231541.2 uc007zqx.1 uc007zqx.2 uc007zqx.3 uc007zqx.4 uc007zqx.1 uc007zqx.2 uc007zqx.3 uc007zqx.4 
ENSMUST00000231549.3 Gm34680 ENSMUST00000231549.3 Gm34680 (from geneSymbol) ENSMUST00000231549.1 ENSMUST00000231549.2 uc289edi.1 uc289edi.2 uc289edi.3 uc289edi.1 uc289edi.2 uc289edi.3 
ENSMUST00000231550.2 Gm49721 ENSMUST00000231550.2 Lysosome lumen (from UniProt Q5FWA0) AK052649 ENSMUST00000231550.1 Q5FWA0 Q5FWA0_MOUSE Rnaset2b uc289gui.1 uc289gui.2 Lysosome lumen Belongs to the RNase T2 family. RNA binding membrane integral component of membrane ribonuclease T2 activity RNA phosphodiester bond hydrolysis, endonucleolytic uc289gui.1 uc289gui.2 
ENSMUST00000231551.2 Gm29880 ENSMUST00000231551.2 Gm29880 (from geneSymbol) ENSMUST00000231551.1 uc289geg.1 uc289geg.2 uc289geg.1 uc289geg.2 
ENSMUST00000231565.4 Gm49785 ENSMUST00000231565.4 Gm49785 (from geneSymbol) ENSMUST00000231565.1 ENSMUST00000231565.2 ENSMUST00000231565.3 uc289cxi.1 uc289cxi.2 uc289cxi.3 uc289cxi.4 uc289cxi.1 uc289cxi.2 uc289cxi.3 uc289cxi.4 
ENSMUST00000231579.2 Hspbap1 ENSMUST00000231579.2 Hspb associated protein 1, transcript variant 1 (from RefSeq NM_175111.3) E9QML8 ENSMUST00000231579.1 HBAP1_MOUSE NM_175111 Pass1 Q8BK58 uc007zbq.1 uc007zbq.2 uc007zbq.3 May play a role in cellular stress response. Interacts with CRYAB and HSPB1. Cytoplasm cellular_component cytoplasm oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors oxidation-reduction process uc007zbq.1 uc007zbq.2 uc007zbq.3 
ENSMUST00000231610.2 Gm41481 ENSMUST00000231610.2 Gm41481 (from geneSymbol) ENSMUST00000231610.1 uc289frt.1 uc289frt.2 uc289frt.1 uc289frt.2 
ENSMUST00000231619.2 Gm49714 ENSMUST00000231619.2 Gm49714 (from geneSymbol) ENSMUST00000231619.1 uc289fxl.1 uc289fxl.2 uc289fxl.1 uc289fxl.2 
ENSMUST00000231640.2 Gm49745 ENSMUST00000231640.2 Gm49745 (from geneSymbol) ENSMUST00000231640.1 uc289dky.1 uc289dky.2 uc289dky.1 uc289dky.2 
ENSMUST00000231647.3 4930470H14Rik ENSMUST00000231647.3 RIKEN cDNA 4930470H14 gene (from RefSeq NR_045764.1) ENSMUST00000231647.1 ENSMUST00000231647.2 NR_045764 uc029szf.1 uc029szf.2 uc029szf.3 uc029szf.1 uc029szf.2 uc029szf.3 
ENSMUST00000231668.2 Gm46559 ENSMUST00000231668.2 Gm46559 (from geneSymbol) ENSMUST00000231668.1 uc289eoh.1 uc289eoh.2 uc289eoh.1 uc289eoh.2 
ENSMUST00000231670.3 Smim34 ENSMUST00000231670.3 small integral membrane protein 34 (from RefSeq NM_001370888.1) ENSMUST00000231670.1 ENSMUST00000231670.2 NM_001370888 uc289gei.1 uc289gei.2 uc289gei.3 uc289gei.1 uc289gei.2 uc289gei.3 
ENSMUST00000231681.2 2610318N02Rik ENSMUST00000231681.2 RIKEN cDNA 2610318N02 gene, transcript variant 2 (from RefSeq NM_001358255.1) 2610318N02Rik ENSMUST00000231681.1 NM_001358255 Q80VT5 Q80VT5_MOUSE uc007ykb.1 uc007ykb.2 uc007ykb.3 molecular_function cellular_component biological_process uc007ykb.1 uc007ykb.2 uc007ykb.3 
ENSMUST00000231686.2 Gm49574 ENSMUST00000231686.2 Gm49574 (from geneSymbol) ENSMUST00000231686.1 uc289fdy.1 uc289fdy.2 uc289fdy.1 uc289fdy.2 
ENSMUST00000231693.2 Gm49632 ENSMUST00000231693.2 Gm49632 (from geneSymbol) ENSMUST00000231693.1 uc289gve.1 uc289gve.2 uc289gve.1 uc289gve.2 
ENSMUST00000231694.2 E130310I04Rik ENSMUST00000231694.2 RIKEN cDNA E130310I04 gene, transcript variant 2 (from RefSeq NR_045723.1) ENSMUST00000231694.1 NR_045723 uc029swx.1 uc029swx.2 uc029swx.3 uc029swx.1 uc029swx.2 uc029swx.3 
ENSMUST00000231700.2 Zdhhc23 ENSMUST00000231700.2 zinc finger, DHHC domain containing 23, transcript variant 2 (from RefSeq NM_001368703.1) A6H5Y4 ENSMUST00000231700.1 Gm779 NM_001368703 Q3UH65 Q3UVA2 Q5Y5T3 ZDH23_MOUSE Zdhhc23 uc007zgr.1 uc007zgr.2 uc007zgr.3 Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes. Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence=; Interacts with NOS1. Golgi apparatus membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Note=Neuronal soma and dendrites. Expressed in the brain. The DHHC domain is required for palmitoyltransferase activity. Belongs to the DHHC palmitoyltransferase family. Sequence=BAE27992.1; Type=Erroneous initiation; Evidence=; endoplasmic reticulum Golgi apparatus protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity protein localization to plasma membrane uc007zgr.1 uc007zgr.2 uc007zgr.3 
ENSMUST00000231701.3 Trat1 ENSMUST00000231701.3 T cell receptor associated transmembrane adaptor 1 (from RefSeq NM_198297.4) ENSMUST00000231701.1 ENSMUST00000231701.2 NM_198297 Q3SXD9 Q3SXE0 Q3UU67 TRAT1_MOUSE uc007zjr.1 uc007zjr.2 uc007zjr.3 Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. Homodimer; disulfide-linked. Interacts with CD3Z. When phosphorylated, interacts with PIK3R1 (By similarity). Cell membrane ; Single-pass type III membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UU67-1; Sequence=Displayed; Name=2; IsoId=Q3UU67-2; Sequence=VSP_016638, VSP_016640; Name=3; Synonyms=DeltaTM-TRIM; IsoId=Q3UU67-3; Sequence=VSP_016639; Present in T-cells (at protein level). Present in thymocytes from 16.5 dpc (at protein level). Phosphorylated on tyrosines upon TCR activation. [Isoform 3]: Strongly expressed at 13.5 dpc, then down- regulated. Marginal in adult. Protein may be unstable. Sequence=AAI04352.2; Type=Erroneous initiation; Evidence=; negative regulation of receptor recycling adaptive immune response immune system process molecular_function plasma membrane membrane integral component of membrane T cell receptor complex positive regulation of calcium-mediated signaling positive regulation of T cell receptor signaling pathway negative regulation of transport uc007zjr.1 uc007zjr.2 uc007zjr.3 
ENSMUST00000231709.2 Gm49614 ENSMUST00000231709.2 Gm49614 (from geneSymbol) AK043180 ENSMUST00000231709.1 uc289fzo.1 uc289fzo.2 uc289fzo.1 uc289fzo.2 
ENSMUST00000231710.2 Gm49620 ENSMUST00000231710.2 Gm49620 (from geneSymbol) ENSMUST00000231710.1 LF200841 uc289ghr.1 uc289ghr.2 uc289ghr.1 uc289ghr.2 
ENSMUST00000231716.2 Cd80 ENSMUST00000231716.2 CD80 antigen, transcript variant 1 (from RefSeq NM_001359898.1) Cd80 ENSMUST00000231716.1 NM_001359898 Q549R2 Q549R2_MOUSE Qoo609 uc007zez.1 uc007zez.2 uc007zez.3 uc007zez.4 Membrane ; Single- pass type I membrane protein coreceptor activity membrane integral component of membrane T cell costimulation uc007zez.1 uc007zez.2 uc007zez.3 uc007zez.4 
ENSMUST00000231720.2 Gm56451 ENSMUST00000231720.2 Gm56451 (from geneSymbol) A0A338P6I9 A0A338P6I9_MOUSE ENSMUST00000231720.1 Gm56451 uc290avs.1 uc290avs.2 membrane integral component of membrane uc290avs.1 uc290avs.2 
ENSMUST00000231727.2 Gm18870 ENSMUST00000231727.2 Gm18870 (from geneSymbol) ENSMUST00000231727.1 uc289fim.1 uc289fim.2 uc289fim.1 uc289fim.2 
ENSMUST00000231728.3 Gm49725 ENSMUST00000231728.3 Gm49725 (from geneSymbol) AK133433 ENSMUST00000231728.1 ENSMUST00000231728.2 uc289gfj.1 uc289gfj.2 uc289gfj.3 uc289gfj.1 uc289gfj.2 uc289gfj.3 
ENSMUST00000231729.3 Gm49762 ENSMUST00000231729.3 Gm49762 (from geneSymbol) ENSMUST00000231729.1 ENSMUST00000231729.2 uc288ooz.1 uc288ooz.2 uc288ooz.3 uc288ooz.1 uc288ooz.2 uc288ooz.3 
ENSMUST00000231734.2 Gm49701 ENSMUST00000231734.2 Gm49701 (from geneSymbol) ENSMUST00000231734.1 uc289fes.1 uc289fes.2 uc289fes.1 uc289fes.2 
ENSMUST00000231741.3 A630089N07Rik ENSMUST00000231741.3 A630089N07Rik (from geneSymbol) A0A338P6Q3 A0A338P6Q3_MOUSE A630089N07Rik AK041610 ENSMUST00000231741.1 ENSMUST00000231741.2 uc289gqa.1 uc289gqa.2 uc289gqa.3 nucleic acid binding uc289gqa.1 uc289gqa.2 uc289gqa.3 
ENSMUST00000231759.2 Gm49666 ENSMUST00000231759.2 Gm49666 (from geneSymbol) ENSMUST00000231759.1 LF200791 uc289fkz.1 uc289fkz.2 uc289fkz.1 uc289fkz.2 
ENSMUST00000231761.2 Gm36903 ENSMUST00000231761.2 Gm36903 (from geneSymbol) ENSMUST00000231761.1 uc289erf.1 uc289erf.2 uc289erf.1 uc289erf.2 
ENSMUST00000231764.2 Gm49715 ENSMUST00000231764.2 Gm49715 (from geneSymbol) ENSMUST00000231764.1 uc289fxo.1 uc289fxo.2 uc289fxo.1 uc289fxo.2 
ENSMUST00000231767.2 Gm49741 ENSMUST00000231767.2 Gm49741 (from geneSymbol) ENSMUST00000231767.1 uc289itw.1 uc289itw.2 uc289itw.1 uc289itw.2 
ENSMUST00000231768.2 Fetub ENSMUST00000231768.2 Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening. (from UniProt Q9QXC1) AK009310 ENSMUST00000231768.1 FETUB_MOUSE Q9QXC1 uc289dsc.1 uc289dsc.2 Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening. Secreted Liver, lung and tongue. Female infertility due to a block early in fertilization. Oocytes undergo premature zona pellucida hardening. Belongs to the fetuin family. enzyme inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular region extracellular space single fertilization binding of sperm to zona pellucida metalloendopeptidase inhibitor activity negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc289dsc.1 uc289dsc.2 
ENSMUST00000231772.2 Gm49648 ENSMUST00000231772.2 Gm49648 (from geneSymbol) ENSMUST00000231772.1 uc289fjy.1 uc289fjy.2 uc289fjy.1 uc289fjy.2 
ENSMUST00000231777.3 Dlg2 ENSMUST00000231777.3 Belongs to the MAGUK family. (from UniProt A0A338P6J0) A0A338P6J0 A0A338P6J0_MOUSE Dlg2 ENSMUST00000231777.1 ENSMUST00000231777.2 MF276899 uc291spk.1 uc291spk.2 uc291spk.3 Belongs to the MAGUK family. uc291spk.1 uc291spk.2 uc291spk.3 
ENSMUST00000231778.2 ENSMUSG00000121443 ENSMUST00000231778.2 predicted gene 6815 (from RefSeq NR_102685.1) ENSMUST00000231778.1 NR_102685 uc033gyy.1 uc033gyy.2 uc033gyy.3 uc033gyy.1 uc033gyy.2 uc033gyy.3 
ENSMUST00000231790.2 Gm49600 ENSMUST00000231790.2 Gm49600 (from geneSymbol) ENSMUST00000231790.1 LF200732 uc289enj.1 uc289enj.2 uc289enj.1 uc289enj.2 
ENSMUST00000231804.2 Gm49789 ENSMUST00000231804.2 Gm49789 (from geneSymbol) ENSMUST00000231804.1 uc289ist.1 uc289ist.2 uc289ist.1 uc289ist.2 
ENSMUST00000231816.2 4933426B08Rik ENSMUST00000231816.2 4933426B08Rik (from geneSymbol) AK016924 ENSMUST00000231816.1 uc289gud.1 uc289gud.2 uc289gud.1 uc289gud.2 
ENSMUST00000231817.2 Gm49622 ENSMUST00000231817.2 Gm49622 (from geneSymbol) ENSMUST00000231817.1 uc289fip.1 uc289fip.2 uc289fip.1 uc289fip.2 
ENSMUST00000231818.2 Gm49790 ENSMUST00000231818.2 Gm49790 (from geneSymbol) ENSMUST00000231818.1 uc289isw.1 uc289isw.2 uc289isw.1 uc289isw.2 
ENSMUST00000231822.2 4933401D09Rik ENSMUST00000231822.2 RIKEN cDNA 4933401D09 gene (from RefSeq NR_045431.1) ENSMUST00000231822.1 NR_045431 uc029tao.1 uc029tao.2 uc029tao.3 uc029tao.1 uc029tao.2 uc029tao.3 
ENSMUST00000231823.4 4930483P17Rik ENSMUST00000231823.4 4930483P17Rik (from geneSymbol) AK019653 ENSMUST00000231823.1 ENSMUST00000231823.2 ENSMUST00000231823.3 uc289dbo.1 uc289dbo.2 uc289dbo.3 uc289dbo.4 uc289dbo.1 uc289dbo.2 uc289dbo.3 uc289dbo.4 
ENSMUST00000231824.2 2600002D14Rik ENSMUST00000231824.2 2600002D14Rik (from geneSymbol) AK019144 ENSMUST00000231824.1 uc289ene.1 uc289ene.2 uc289ene.1 uc289ene.2 
ENSMUST00000231830.2 Gm49730 ENSMUST00000231830.2 Gm49730 (from geneSymbol) ENSMUST00000231830.1 uc289ejp.1 uc289ejp.2 uc289ejp.1 uc289ejp.2 
ENSMUST00000231846.2 4930478L05Rik ENSMUST00000231846.2 RIKEN cDNA 4930478L05 gene (from RefSeq NR_040569.1) ENSMUST00000231846.1 NR_040569 uc029sye.1 uc029sye.2 uc029sye.1 uc029sye.2 
ENSMUST00000231851.2 Gm49795 ENSMUST00000231851.2 Gm49795 (from geneSymbol) ENSMUST00000231851.1 uc289isn.1 uc289isn.2 uc289isn.1 uc289isn.2 
ENSMUST00000231893.2 Gm32431 ENSMUST00000231893.2 Gm32431 (from geneSymbol) ENSMUST00000231893.1 uc289ezs.1 uc289ezs.2 uc289ezs.1 uc289ezs.2 
ENSMUST00000231907.3 4930551I23Rik ENSMUST00000231907.3 4930551I23Rik (from geneSymbol) AK016094 ENSMUST00000231907.1 ENSMUST00000231907.2 uc289fsd.1 uc289fsd.2 uc289fsd.3 uc289fsd.1 uc289fsd.2 uc289fsd.3 
ENSMUST00000231918.3 Gm38477 ENSMUST00000231918.3 Gm38477 (from geneSymbol) AK133303 ENSMUST00000231918.1 ENSMUST00000231918.2 uc007ztz.1 uc007ztz.2 uc007ztz.3 uc007ztz.1 uc007ztz.2 uc007ztz.3 
ENSMUST00000231923.2 Gm49694 ENSMUST00000231923.2 Gm49694 (from geneSymbol) ENSMUST00000231923.1 uc288zka.1 uc288zka.2 uc288zka.1 uc288zka.2 
ENSMUST00000231925.2 Gm49773 ENSMUST00000231925.2 Gm49773 (from geneSymbol) ENSMUST00000231925.1 uc289ita.1 uc289ita.2 uc289ita.1 uc289ita.2 
ENSMUST00000231927.2 Rnaset2a ENSMUST00000231927.2 ribonuclease T2A, transcript variant 3 (from RefSeq NM_001364953.1) ENSMUST00000231927.1 NM_001364953 Q5FWA0 Q5FWA0_MOUSE Rnaset2b uc289gvv.1 uc289gvv.2 Lysosome lumen Belongs to the RNase T2 family. RNA binding membrane integral component of membrane ribonuclease T2 activity RNA phosphodiester bond hydrolysis, endonucleolytic uc289gvv.1 uc289gvv.2 
ENSMUST00000231931.2 Gm49731 ENSMUST00000231931.2 Gm49731 (from geneSymbol) ENSMUST00000231931.1 uc289eba.1 uc289eba.2 uc289eba.1 uc289eba.2 
ENSMUST00000231935.2 Gm49555 ENSMUST00000231935.2 Gm49555 (from geneSymbol) ENSMUST00000231935.1 uc289frg.1 uc289frg.2 uc289frg.1 uc289frg.2 
ENSMUST00000231941.2 Bex6 ENSMUST00000231941.2 brain expressed family member 6 (from RefSeq NM_001033539.2) A2RSJ0 BEX6_MOUSE ENSMUST00000231941.1 NM_001033539 Q3TZW7 uc007yyk.1 uc007yyk.2 uc007yyk.3 Cytoplasm Ubiquitinated (PubMed:15958283). Degraded by the proteasome (PubMed:15958283). The human orthologous protein seems not to exist. Belongs to the BEX family. molecular_function nucleus cytoplasm biological_process uc007yyk.1 uc007yyk.2 uc007yyk.3 
ENSMUST00000231944.2 Gm49660 ENSMUST00000231944.2 Gm49660 (from geneSymbol) ENSMUST00000231944.1 uc289fmm.1 uc289fmm.2 uc289fmm.1 uc289fmm.2 
ENSMUST00000231951.2 4930549P19Rik ENSMUST00000231951.2 4930549P19Rik (from geneSymbol) AK016082 ENSMUST00000231951.1 uc289hku.1 uc289hku.2 uc289hku.1 uc289hku.2 
ENSMUST00000231952.2 Gm49559 ENSMUST00000231952.2 Gm49559 (from geneSymbol) AK145320 ENSMUST00000231952.1 uc289frk.1 uc289frk.2 uc289frk.1 uc289frk.2 
ENSMUST00000231959.3 Gm49757 ENSMUST00000231959.3 Gm49757 (from geneSymbol) ENSMUST00000231959.1 ENSMUST00000231959.2 uc289dyz.1 uc289dyz.2 uc289dyz.3 uc289dyz.1 uc289dyz.2 uc289dyz.3 
ENSMUST00000231960.2 Gm49702 ENSMUST00000231960.2 Gm49702 (from geneSymbol) ENSMUST00000231960.1 uc289eiq.1 uc289eiq.2 uc289eiq.1 uc289eiq.2 
ENSMUST00000231968.2 Gm46555 ENSMUST00000231968.2 Gm46555 (from geneSymbol) ENSMUST00000231968.1 uc289geo.1 uc289geo.2 uc289geo.1 uc289geo.2 
ENSMUST00000231969.2 Gmnc ENSMUST00000231969.2 geminin coiled-coil domain containing, transcript variant 2 (from RefSeq NM_001285916.1) ENSMUST00000231969.1 GEMC1_MOUSE Gemc1 Gm606 NM_001285916 Q3TUK3 Q3URY2 Q5RJG4 uc007yvi.1 uc007yvi.2 uc007yvi.3 Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity). Nucleus Note=Associates with chromatin during pre-replication complex (pre-RC) formation. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3URY2-1; Sequence=Displayed; Name=2; IsoId=Q3URY2-2; Sequence=VSP_034993; Name=3; IsoId=Q3URY2-3; Sequence=VSP_034992; Highly phosphorylated by CDK2; stimulates initiation of DNA replication. Belongs to the GEMC1 family. molecular_function chromatin binding cellular_component nucleus DNA replication DNA replication initiation cell cycle cell proliferation cilium assembly uc007yvi.1 uc007yvi.2 uc007yvi.3 
ENSMUST00000231977.2 8030451O07Rik ENSMUST00000231977.2 RIKEN cDNA 8030451O07 gene, transcript variant 2 (from RefSeq NR_131116.1) ENSMUST00000231977.1 NR_131116 uc007zqy.1 uc007zqy.2 uc007zqy.3 uc007zqy.1 uc007zqy.2 uc007zqy.3 
ENSMUST00000231978.3 Gm15760 ENSMUST00000231978.3 predicted gene 15760 (from RefSeq NR_030670.1) ENSMUST00000231978.1 ENSMUST00000231978.2 NR_030670 uc012act.1 uc012act.2 uc012act.3 uc012act.4 uc012act.1 uc012act.2 uc012act.3 uc012act.4 
ENSMUST00000231988.2 Map3k13 ENSMUST00000231988.2 Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB- containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity). (from UniProt Q1HKZ5) AK051378 ENSMUST00000231988.1 M3K13_MOUSE Q1HKZ5 Q8BKN0 uc289dpl.1 uc289dpl.2 Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB- containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by autophosphorylation and homodimerization. Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP1 through the kinase catalytic domain. Binds PRDX3. Associates with the IKK complex through the kinase domain. Cytoplasm. Membrane ; Peripheral membrane protein Autophosphorylated on serine and threonine residues. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. nucleotide binding activation of MAPKK activity protein kinase activity protein serine/threonine kinase activity JUN kinase kinase kinase activity MAP kinase kinase kinase activity ATP binding cytoplasm protein phosphorylation JNK cascade activation of JNKK activity activation of JUN kinase activity positive regulation of neuron maturation membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation enzyme binding identical protein binding protein homodimerization activity positive regulation of axon extension protein autophosphorylation metal ion binding positive regulation of NF-kappaB transcription factor activity positive regulation of branching morphogenesis of a nerve uc289dpl.1 uc289dpl.2 
ENSMUST00000232003.2 Gm49677 ENSMUST00000232003.2 Gm49677 (from geneSymbol) AK049026 ENSMUST00000232003.1 uc289fmx.1 uc289fmx.2 uc289fmx.1 uc289fmx.2 
ENSMUST00000232004.2 Gm49761 ENSMUST00000232004.2 Gm49761 (from geneSymbol) ENSMUST00000232004.1 uc289hnr.1 uc289hnr.2 uc289hnr.1 uc289hnr.2 
ENSMUST00000232007.2 Gm49766 ENSMUST00000232007.2 Gm49766 (from geneSymbol) ENSMUST00000232007.1 uc287rwh.1 uc287rwh.2 uc287rwh.1 uc287rwh.2 
ENSMUST00000232011.2 Gm49598 ENSMUST00000232011.2 Gm49598 (from geneSymbol) ENSMUST00000232011.1 uc289dia.1 uc289dia.2 uc289dia.1 uc289dia.2 
ENSMUST00000232014.2 4930403O18Rik ENSMUST00000232014.2 4930403O18Rik (from geneSymbol) ENSMUST00000232014.1 uc289fqr.1 uc289fqr.2 uc289fqr.1 uc289fqr.2 
ENSMUST00000232028.3 4930404A05Rik ENSMUST00000232028.3 4930404A05Rik (from geneSymbol) AK015072 ENSMUST00000232028.1 ENSMUST00000232028.2 uc007zlj.1 uc007zlj.2 uc007zlj.3 uc007zlj.1 uc007zlj.2 uc007zlj.3 
ENSMUST00000232032.3 Gm49796 ENSMUST00000232032.3 Gm49796 (from geneSymbol) ENSMUST00000232032.1 ENSMUST00000232032.2 uc289iso.1 uc289iso.2 uc289iso.3 uc289iso.1 uc289iso.2 uc289iso.3 
ENSMUST00000232037.2 Gm49636 ENSMUST00000232037.2 Gm49636 (from geneSymbol) AK143771 ENSMUST00000232037.1 uc289dxm.1 uc289dxm.2 uc289dxm.1 uc289dxm.2 
ENSMUST00000232042.2 Gm49797 ENSMUST00000232042.2 Gm49797 (from geneSymbol) BC040266 ENSMUST00000232042.1 uc008aen.1 uc008aen.2 uc008aen.3 uc008aen.4 uc008aen.1 uc008aen.2 uc008aen.3 uc008aen.4 
ENSMUST00000232052.2 D16Ertd472e ENSMUST00000232052.2 DNA segment, Chr 16, ERATO Doi 472, expressed, transcript variant 2 (from RefSeq NM_025967.4) D16Ertd472e ENSMUST00000232052.1 EURL_MOUSE Eurl NM_025967 Q9D7G4 uc007zsr.1 uc007zsr.2 uc007zsr.3 uc007zsr.4 uc007zsr.5 Plays a role in cortical progenitor cell proliferation and differentiation (PubMed:27404227). Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta- catenin signaling pathway (PubMed:27404227). Interacts with CCDC85B (PubMed:27404227). Expressed in brain (at protein level) (PubMed:27404227). Expressed in neural progenitor cells and postmitotic neurons of the embryonic cerebral cortex (PubMed:27404227). Expressed in the embryonic cortex and germinal ventricular zone (PubMed:27404227). Expressed in cells of the cortical plate and in retinal pigment epithelium and lens between 12 and 14 dpc (at protein level) (PubMed:27404227). Belongs to the EURL family. protein binding cellular_component nervous system development cerebral cortex neuron differentiation cell differentiation positive regulation of dendritic spine development uc007zsr.1 uc007zsr.2 uc007zsr.3 uc007zsr.4 uc007zsr.5 
ENSMUST00000232065.2 Gm49617 ENSMUST00000232065.2 Gm49617 (from geneSymbol) ENSMUST00000232065.1 uc289ghh.1 uc289ghh.2 uc289ghh.1 uc289ghh.2 
ENSMUST00000232072.2 Itgb1bp1 ENSMUST00000232072.2 Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. (from UniProt O35671) AJ001373 ENSMUST00000232072.1 ITBP1_MOUSE O35671 Q542A8 uc288fik.1 uc288fik.2 Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (via C-terminal region) with ITGB1 (via C-terminal cytoplasmic tail); the interaction prevents talin TLN1 binding to ITGB1 and KRIT1 and ITGB1 compete for the same binding site. Interacts with KRIT1 (via N-terminal NPXY motif); the interaction induces the opening conformation of KRIT1 and KRIT1 and ITGB1 compete for the same binding site. Isoform 2 does not interact with ITGB1. Interacts with CDC42 (GTP- or GDP-bound form); the interaction is increased with the CDC42- membrane bound forms and prevents both CDC42 activation and cell spreading. Interacts (via C-terminal domain region) with NME2. Interacts with FERMT2 and RAC1 (By similarity). Interacts (via N- terminus and PTB domain) with ROCK1. Nucleus Cytoplasm Cytoplasm, cytoskeleton Cell membrane Cell projection, lamellipodium Cell projection, ruffle Note=Nucleocytoplasmic shuttling protein; shuttles between nucleus and cytoplasm in an integrin- dependent manner; probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin; cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 integrin- rich peripheral ruffles and lamellipodia during initial cell spreading on fibronectin and/or collagen (By similarity). Expressed in the brain. First expressed in the heart primordium at 8.5 dpc. Phosphorylation at Thr-38 seems to enhance integrin alpha5beta1- mediated cell adhesion. The degree of phosphorylation is regulated by integrin-dependent cell-matrix interaction (By similarity). Mice show severe defects in osteoblast mesenchymal cells to compaction, proliferation, differentiation, and mineralization and to a delay in bone nodule formation. Suffer also from an excessive microvessel growth. angiogenesis ruffle blood vessel endothelial cell proliferation involved in sprouting angiogenesis GDP-dissociation inhibitor activity integrin binding protein binding nucleus nucleoplasm cytoplasm microtubule organizing center cytosol cytoskeleton plasma membrane negative regulation of protein kinase activity negative regulation of cell adhesion involved in substrate-bound cell migration cell adhesion cell-matrix adhesion Notch signaling pathway integrin-mediated signaling pathway protein C-terminus binding positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of endothelial cell migration negative regulation of fibroblast migration membrane nuclear body kinase binding protein kinase binding lamellipodium cell differentiation regulation of cell adhesion biomineral tissue development negative regulation of protein binding activation of protein kinase B activity integrin activation regulation of cell adhesion mediated by integrin tube formation cellular response to vascular endothelial growth factor stimulus cell projection regulation of GTPase activity receptor clustering cellular response to fibroblast growth factor stimulus positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter perinuclear region of cytoplasm myoblast migration positive regulation of stress fiber assembly positive regulation of cell division positive regulation of focal adhesion assembly negative regulation of focal adhesion assembly positive regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade cell periphery protein localization to plasma membrane negative regulation of cell migration involved in sprouting angiogenesis positive regulation of protein targeting to membrane negative regulation of protein targeting to membrane regulation of blood vessel diameter negative regulation of substrate adhesion-dependent cell spreading regulation of integrin-mediated signaling pathway focal adhesion uc288fik.1 uc288fik.2 
ENSMUST00000232090.2 Vmn2r95 ENSMUST00000232090.2 vomeronasal 2, receptor 95 (from RefSeq NM_001102581.1) A0A338P6T0 A0A338P6T0_MOUSE ENSMUST00000232090.1 NM_001102581 Vmn2r95 uc009vba.1 uc009vba.2 uc009vba.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc009vba.1 uc009vba.2 uc009vba.3 
ENSMUST00000232091.2 Gm31641 ENSMUST00000232091.2 predicted gene, 31641 (from RefSeq NR_153766.1) ENSMUST00000232091.1 NR_153766 uc008abr.1 uc008abr.2 uc008abr.3 uc008abr.4 uc008abr.1 uc008abr.2 uc008abr.3 uc008abr.4 
ENSMUST00000232105.2 Gm21989 ENSMUST00000232105.2 Gm21989 (from geneSymbol) AK018309 ENSMUST00000232105.1 uc288fig.1 uc288fig.2 uc288fig.1 uc288fig.2 
ENSMUST00000232118.2 Gm49604 ENSMUST00000232118.2 Gm49604 (from geneSymbol) DQ552040 ENSMUST00000232118.1 uc289fql.1 uc289fql.2 uc289fql.1 uc289fql.2 
ENSMUST00000232122.3 Gm49586 ENSMUST00000232122.3 Gm49586 (from geneSymbol) ENSMUST00000232122.1 ENSMUST00000232122.2 uc288fji.1 uc288fji.2 uc288fji.3 uc288fji.1 uc288fji.2 uc288fji.3 
ENSMUST00000232124.2 Gm49742 ENSMUST00000232124.2 Gm49742 (from geneSymbol) ENSMUST00000232124.1 uc289doe.1 uc289doe.2 uc289doe.1 uc289doe.2 
ENSMUST00000232133.2 Gm49794 ENSMUST00000232133.2 Gm49794 (from geneSymbol) ENSMUST00000232133.1 uc008boc.1 uc008boc.2 uc008boc.3 uc008boc.4 uc008boc.1 uc008boc.2 uc008boc.3 uc008boc.4 
ENSMUST00000232135.2 Gm49625 ENSMUST00000232135.2 Gm49625 (from geneSymbol) ENSMUST00000232135.1 KY467762 uc289gai.1 uc289gai.2 uc289gai.1 uc289gai.2 
ENSMUST00000232139.2 Ube2l3 ENSMUST00000232139.2 Belongs to the ubiquitin-conjugating enzyme family. (from UniProt Q561N4) ENSMUST00000232139.1 Q561N4 Q561N4_MOUSE Ube2l3 X97042 uc289cuy.1 uc289cuy.2 Belongs to the ubiquitin-conjugating enzyme family. nucleotide binding ATP binding transferase activity uc289cuy.1 uc289cuy.2 
ENSMUST00000232144.2 Gm49776 ENSMUST00000232144.2 Gm49776 (from geneSymbol) A0A338P691 A0A338P691_MOUSE AK161410 ENSMUST00000232144.1 Gm49776 uc289dby.1 uc289dby.2 RNA binding heme binding primary miRNA processing identical protein binding microprocessor complex uc289dby.1 uc289dby.2 
ENSMUST00000232150.2 Stfa1 ENSMUST00000232150.2 stefin A1 (from RefSeq NM_001082543.1) CYT1_MOUSE ENSMUST00000232150.1 NM_001082543 P35175 Stf-1 Stf1 uc007zck.1 uc007zck.2 uc007zck.3 This is an intracellular thiol proteinase inhibitor. Cytoplasm Belongs to the cystatin family. endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity cytoplasm cytosol negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity uc007zck.1 uc007zck.2 uc007zck.3 
ENSMUST00000232154.2 Gm36169 ENSMUST00000232154.2 Gm36169 (from geneSymbol) BC024845 ENSMUST00000232154.1 uc289fxn.1 uc289fxn.2 uc289fxn.1 uc289fxn.2 
ENSMUST00000232155.2 6430553K19Rik ENSMUST00000232155.2 RIKEN cDNA 6430553K19 gene (from RefSeq NR_152166.1) ENSMUST00000232155.1 NR_152166 uc289exw.1 uc289exw.2 uc289exw.1 uc289exw.2 
ENSMUST00000232179.2 Atm ENSMUST00000232179.2 Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:19047460). Recognizes the substrate consensus sequence [ST]-Q (PubMed:19047460). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (PubMed:11571274). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes (By similarity). After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele (PubMed:19448632). Also involved in signal transduction and cell cycle control (By similarity). May function as a tumor suppressor (By similarity). Necessary for activation of ABL1 and SAPK (By similarity). Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (By similarity). May play a role in vesicle and/or protein transport (By similarity). Could play a role in T-cell development, gonad and neurological function (By similarity). Binds DNA ends (By similarity). Plays a role in replication-dependent histone mRNA degradation (By similarity). Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (By similarity). Phosphorylates ATF2 which stimulates its function in DNA damage response (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (By similarity). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (By similarity). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (By similarity). (from UniProt Q62388) ATM_MOUSE E9QNY7 ENSMUST00000232179.1 Q62388 U43678 uc009pmd.1 uc009pmd.2 uc009pmd.3 uc009pmd.4 Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:19047460). Recognizes the substrate consensus sequence [ST]-Q (PubMed:19047460). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (PubMed:11571274). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes (By similarity). After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele (PubMed:19448632). Also involved in signal transduction and cell cycle control (By similarity). May function as a tumor suppressor (By similarity). Necessary for activation of ABL1 and SAPK (By similarity). Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (By similarity). May play a role in vesicle and/or protein transport (By similarity). Could play a role in T-cell development, gonad and neurological function (By similarity). Binds DNA ends (By similarity). Plays a role in replication-dependent histone mRNA degradation (By similarity). Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (By similarity). Phosphorylates ATF2 which stimulates its function in DNA damage response (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (By similarity). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (By similarity). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Inhibited by wortmannin. Homodimer (By similarity). Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers rendering them catalytically active. Binds DNA ends, p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. DNA damage promotes association with RAD17. Interacts with EEF1E1; the interaction, induced on DNA damage, up-regulates TP53. Interacts with DCLRE1C, MYST1, KAT5, NABP2, ATMIN and CEP164 (By similarity). Interacts with AP2B1 and AP3B2; the interaction occurs in cytoplasmic vesicles (PubMed:9707615). Interacts with TELO2 and TTI1. Interacts with DDX1 (By similarity). Interacts with BRAT1 (By similarity). Interacts with CYREN (via XLF motif) (PubMed:30017584). Interacts (via microbody targeting signal) with PEX5; promoting translocation to peroxisomes in response to reactive oxygen species (ROS) (By similarity). Nucleus Cytoplasmic vesicle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Peroxisome matrix Note=Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin. Translocated to peroxisomes in response to reactive oxygen species (ROS) by PEX5. Expressed in brain, skeletal muscle, testis, followed by spleen, lung, kidney, heart, liver and thymus. Ubiquitously expressed in embryonal tissues. Highest expression in embryonic central nervous system, from 13.5 dpc day and during the whole cerebellar development. Decreased expression when maturation occurs. The FATC domain is required for interaction with KAT5. Phosphorylated by NUAK1/ARK5 (By similarity). Autophosphorylation on Ser-367, Ser-1899, Ser-1987 correlates with DNA damage-mediated activation of the kinase. Phosphorylated by NUAK1/ARK5. Autophosphorylation on Ser-367, Ser- 1899, Ser-1987 correlates with DNA damage-mediated activation of the kinase. During the late stages of DNA damage response, dephosphorylated following deacetylation by SIRT7, leading to ATM deactivation. Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and subsequent autophosphorylation on Ser-1987. Acetylated in vitro by KAT5/TIP60. Deacetylated by SIRT7 during the late stages of DNA damage response, promoting ATM dephosphorylation and subsequent deactivation. Atm-disrupted mice recapitulate the human ataxia telangiectasia phenotype. Mice homozygous for the disrupted Atm allele display growth retardation, neurologic dysfunction, male and female infertility secondary to the absence of mature gametes, defects in T lymphocyte maturation, and extreme sensitivity to gamma-irradiation. Belongs to the PI3/PI4-kinase family. ATM subfamily. DNA damage checkpoint nucleotide binding telomere maintenance double-strand break repair via homologous recombination chromosome, telomeric region ovarian follicle development response to hypoxia somitogenesis pre-B cell allelic exclusion immune system process immunoglobulin production DNA binding protein kinase activity protein serine/threonine kinase activity DNA-dependent protein kinase activity protein binding ATP binding nucleus nucleoplasm nucleolus cytoplasm spindle DNA repair protein phosphorylation apoptotic process cellular response to DNA damage stimulus DNA damage induced protein phosphorylation cell cycle cell cycle arrest mitotic spindle assembly checkpoint male meiosis female meiotic division female gamete generation brain development heart development determination of adult lifespan female gonad development intrinsic apoptotic signaling pathway in response to DNA damage post-embryonic development response to ionizing radiation regulation of autophagy positive regulation of gene expression kinase activity 1-phosphatidylinositol-3-kinase activity phosphorylation histone phosphorylation transferase activity peptidyl-serine phosphorylation positive regulation of cell migration negative regulation of B cell proliferation cytoplasmic vesicle regulation of telomere maintenance via telomerase positive regulation of telomere maintenance via telomerase positive regulation of histone phosphorylation V(D)J recombination multicellular organism growth phosphatidylinositol-3-phosphate biosynthetic process peptidyl-serine autophosphorylation lipoprotein catabolic process positive regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of neuron apoptotic process macromolecular complex binding meiotic telomere clustering positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation protein dimerization activity protein N-terminus binding thymus development oocyte development neuron apoptotic process regulation of cell cycle chromosome organization involved in meiotic cell cycle histone mRNA catabolic process cellular response to retinoic acid cellular response to gamma radiation cellular response to X-ray cellular response to nitrosative stress signal transduction involved in mitotic G2 DNA damage checkpoint replicative senescence establishment of RNA localization to telomere positive regulation of neuron death positive regulation of DNA catabolic process regulation of microglial cell activation negative regulation of TORC1 signaling negative regulation of telomere capping positive regulation of telomere maintenance via telomere lengthening positive regulation of telomerase catalytic core complex assembly DNA repair complex positive regulation of response to DNA damage stimulus uc009pmd.1 uc009pmd.2 uc009pmd.3 uc009pmd.4 
ENSMUST00000232180.2 Arid1b ENSMUST00000232180.2 Nucleus (from UniProt A0A338P6U8) A0A338P6U8 A0A338P6U8_MOUSE AK160334 Arid1b ENSMUST00000232180.1 uc289gro.1 uc289gro.2 Nucleus DNA binding nucleus chromatin remodeling SWI/SNF complex brahma complex nBAF complex uc289gro.1 uc289gro.2 
ENSMUST00000232183.2 Gm49692 ENSMUST00000232183.2 Gm49692 (from geneSymbol) ENSMUST00000232183.1 uc288fhd.1 uc288fhd.2 uc288fhd.1 uc288fhd.2 
ENSMUST00000232211.2 Gm41495 ENSMUST00000232211.2 Gm41495 (from geneSymbol) ENSMUST00000232211.1 uc289gee.1 uc289gee.2 uc289gee.1 uc289gee.2 
ENSMUST00000232216.2 Gm34256 ENSMUST00000232216.2 Gm34256 (from geneSymbol) ENSMUST00000232216.1 uc289eai.1 uc289eai.2 uc289eai.1 uc289eai.2 
ENSMUST00000232229.2 Gm49748 ENSMUST00000232229.2 Gm49748 (from geneSymbol) ENSMUST00000232229.1 uc289dlf.1 uc289dlf.2 uc289dlf.1 uc289dlf.2 
ENSMUST00000232234.2 Gm41442 ENSMUST00000232234.2 Gm41442 (from geneSymbol) ENSMUST00000232234.1 uc289dzm.1 uc289dzm.2 uc289dzm.1 uc289dzm.2 
ENSMUST00000232249.2 Gm49615 ENSMUST00000232249.2 Gm49615 (from geneSymbol) ENSMUST00000232249.1 EU234033 uc289fhy.1 uc289fhy.2 uc289fhy.1 uc289fhy.2 
ENSMUST00000232250.2 Gm41504 ENSMUST00000232250.2 Gm41504 (from geneSymbol) AK158737 ENSMUST00000232250.1 uc289gka.1 uc289gka.2 uc289gka.1 uc289gka.2 
ENSMUST00000232254.2 Gm36363 ENSMUST00000232254.2 Gm36363 (from geneSymbol) ENSMUST00000232254.1 uc289fyd.1 uc289fyd.2 uc289fyd.1 uc289fyd.2 
ENSMUST00000232257.2 Gm30124 ENSMUST00000232257.2 Gm30124 (from geneSymbol) BC024416 ENSMUST00000232257.1 uc288fif.1 uc288fif.2 uc288fif.1 uc288fif.2 
ENSMUST00000232286.2 Gm49590 ENSMUST00000232286.2 Gm49590 (from geneSymbol) AK028729 ENSMUST00000232286.1 uc289fqi.1 uc289fqi.2 uc289fqi.1 uc289fqi.2 
ENSMUST00000232288.2 Gm53028 ENSMUST00000232288.2 Gm53028 (from geneSymbol) ENSMUST00000232288.1 uc289him.1 uc289him.2 uc289him.1 uc289him.2 
ENSMUST00000232290.2 Gm49755 ENSMUST00000232290.2 Gm49755 (from geneSymbol) AK136047 ENSMUST00000232290.1 uc007ywz.1 uc007ywz.2 uc007ywz.1 uc007ywz.2 
ENSMUST00000232294.2 Pigp ENSMUST00000232294.2 Part of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. (from UniProt Q9JHG1) AF216308 Dcrc Dscr5 ENSMUST00000232294.1 PIGP_MOUSE Pigp Q9JHG1 uc289gih.1 uc289gih.2 Part of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Component of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts directly with PIGA and PIGQ. Membrane ; Multi-pass membrane protein Expressed in tongue. Belongs to the PIGP family. Name=Functional Glycomics Gateway - GTase; Note=PIG- P_DCRC-1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_593"; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex endoplasmic reticulum GPI anchor biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups phosphatidylinositol N-acetylglucosaminyltransferase activity uc289gih.1 uc289gih.2 
ENSMUST00000232307.2 Gm49673 ENSMUST00000232307.2 Lysosome lumen (from UniProt Q5FWA0) AK018722 ENSMUST00000232307.1 Q5FWA0 Q5FWA0_MOUSE Rnaset2b uc289gvt.1 uc289gvt.2 Lysosome lumen Belongs to the RNase T2 family. RNA binding membrane integral component of membrane ribonuclease T2 activity RNA phosphodiester bond hydrolysis, endonucleolytic uc289gvt.1 uc289gvt.2 
ENSMUST00000232314.2 Gata6os ENSMUST00000232314.2 Gata6os (from geneSymbol) AK018581 ENSMUST00000232314.1 uc289nzf.1 uc289nzf.2 uc289nzf.1 uc289nzf.2 
ENSMUST00000232316.2 Gm49712 ENSMUST00000232316.2 Gm49712 (from geneSymbol) AK040366 ENSMUST00000232316.1 uc289ean.1 uc289ean.2 uc289ean.1 uc289ean.2 
ENSMUST00000232317.2 Gm49569 ENSMUST00000232317.2 Gm49569 (from geneSymbol) AY968603 ENSMUST00000232317.1 uc289eod.1 uc289eod.2 uc289eod.1 uc289eod.2 
ENSMUST00000232323.2 Gm49584 ENSMUST00000232323.2 Gm49584 (from geneSymbol) ENSMUST00000232323.1 uc289cud.1 uc289cud.2 uc289cud.1 uc289cud.2 
ENSMUST00000232326.3 4930534H18Rik ENSMUST00000232326.3 4930534H18Rik (from geneSymbol) AK019718 ENSMUST00000232326.1 ENSMUST00000232326.2 uc007zwv.1 uc007zwv.2 uc007zwv.3 uc007zwv.1 uc007zwv.2 uc007zwv.3 
ENSMUST00000232332.3 Gm1043 ENSMUST00000232332.3 predicted gene 1043 (from RefSeq NM_001370827.1) A0A338P719 A0A338P719_MOUSE ENSMUST00000232332.1 ENSMUST00000232332.2 Gm1043 NM_001370827 uc290uxv.1 uc290uxv.2 molecular_function cellular_component biological_process uc290uxv.1 uc290uxv.2 
ENSMUST00000232334.2 Gm49727 ENSMUST00000232334.2 Gm49727 (from geneSymbol) ENSMUST00000232334.1 uc289fyh.1 uc289fyh.2 uc289fyh.1 uc289fyh.2 
ENSMUST00000232340.2 Gm536 ENSMUST00000232340.2 Gm536 (from geneSymbol) AK029404 ENSMUST00000232340.1 uc289eaj.1 uc289eaj.2 uc289eaj.1 uc289eaj.2 
ENSMUST00000232361.2 Gm53013 ENSMUST00000232361.2 Gm53013 (from geneSymbol) AK163488 ENSMUST00000232361.1 uc292ojn.1 uc292ojn.2 uc292ojn.1 uc292ojn.2 
ENSMUST00000232363.2 Gm10505 ENSMUST00000232363.2 predicted gene 10505, transcript variant 7 (from RefSeq NR_168740.1) ENSMUST00000232363.1 NR_168740 uc289irx.1 uc289irx.2 uc289irx.1 uc289irx.2 
ENSMUST00000232369.2 Gm49565 ENSMUST00000232369.2 Gm49565 (from geneSymbol) AK156748 ENSMUST00000232369.1 uc289drh.1 uc289drh.2 uc289drh.1 uc289drh.2 
ENSMUST00000232375.2 Gm49706 ENSMUST00000232375.2 Gm49706 (from geneSymbol) AK141639 ENSMUST00000232375.1 uc289eis.1 uc289eis.2 uc289eis.1 uc289eis.2 
ENSMUST00000232378.3 Gm41480 ENSMUST00000232378.3 Gm41480 (from geneSymbol) ENSMUST00000232378.1 ENSMUST00000232378.2 uc289frn.1 uc289frn.2 uc289frn.3 uc289frn.1 uc289frn.2 uc289frn.3 
ENSMUST00000232402.2 Gm29719 ENSMUST00000232402.2 predicted gene, 29719 (from RefSeq NR_163600.2) ENSMUST00000232402.1 NR_163600 uc289gth.1 uc289gth.2 uc289gth.1 uc289gth.2 
ENSMUST00000232426.2 Gm49573 ENSMUST00000232426.2 Gm49573 (from geneSymbol) AK016675 ENSMUST00000232426.1 uc289cvf.1 uc289cvf.2 uc289cvf.1 uc289cvf.2 
ENSMUST00000232437.2 Pacsin1 ENSMUST00000232437.2 protein kinase C and casein kinase substrate in neurons 1, transcript variant 1 (from RefSeq NM_011861.3) ENSMUST00000232437.1 NM_011861 PACN1_MOUSE Pacsin Q61644 uc008bpj.1 uc008bpj.2 uc008bpj.3 uc008bpj.4 Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission. Homodimer. May form heterooligomers with other PACSINs. Interacts with both COBL and DBNL. Identified in a complex composed of COBL, PACSIN1 and WASL. Interacts with EHD3 (By similarity). Interacts (via SH3 domain) with SYNJ1 and WASL. Interacts (via SH3 domain) with DNM1; the interaction is reduced by DNM1 phosphorylation. Interacts with DNM2 and DNM3. Interacts with MAPT. Interacts with EHD1. Interacts with TRPV4. Q61644; P10637: Mapt; NbExp=5; IntAct=EBI-2255561, EBI-774043; Q61644; Q61644: Pacsin1; NbExp=3; IntAct=EBI-2255561, EBI-2255561; Q61644; P19332-5: Mapt; Xeno; NbExp=6; IntAct=EBI-2255561, EBI-8758676; Cytoplasm. Cell projection Synapse, synaptosome Cell projection, ruffle membrane. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Synapse. Cytoplasm, cytosol. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Note=In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Colocalizes with MAPT in axons. Highly expressed in brain. Detected in hippocampus and dorsal root ganglion neurons. Detected in rod photoreceptor terminals in the outer plexiform layer of the retina (at protein level). In CNS neurons, high levels in the pyramidal cells of the hippocampus, Purkinje cells of the cerebellum and large neurons of the cortex and brain stem. Expression is seen at embryonic day 17 and is up- regulated developmentally with a correlation to neuronal differentiation. The F-BAR domain forms a coiled coil and mediates membrane- binding and membrane tubulation. In the autoinhibited conformation, interaction with the SH3 domain inhibits membrane tubulation mediated by the F-BAR domain. DNM1 binding abolishes autoinhibition. Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). Mice are born at the expected Mendelian rate, but display a slightly reduced body weight and reduced fertility. Mice display increased synaptic vesicle diameter and impaired compensatory synaptic vesicle endocytosis after high synapse activity. Rod photoreceptor ribbon synapses display an abnormally high number of endosome-like structures and tubular elements after light exposure. Mice display defects in excitatory and inhibitory synaptic transmission in the hippocampus, and display a tendency to seizures when confronted with novelty. Belongs to the PACSIN family. protein binding phospholipid binding cytoplasm cytosol cytoskeleton plasma membrane endocytosis cytoskeleton organization actin filament organization signal transduction cytoskeletal protein binding lipid binding membrane cell junction COPI-coated vesicle cytoplasmic vesicle membrane cytoplasmic vesicle ruffle membrane identical protein binding cell projection neuron projection myelin sheath axon terminus synapse negative regulation of endocytosis perinuclear region of cytoplasm synaptic vesicle endocytosis neuron development neuron projection morphogenesis protein localization to membrane protein localization to plasma membrane plasma membrane tubulation presynaptic endocytic zone postsynaptic density membrane glutamatergic synapse positive regulation of dendrite development trans-Golgi network uc008bpj.1 uc008bpj.2 uc008bpj.3 uc008bpj.4 
ENSMUST00000232439.3 Gm26744 ENSMUST00000232439.3 predicted gene, 49607 (from RefSeq NR_188891.1) ENSMUST00000232439.1 ENSMUST00000232439.2 NR_188891 uc007yrq.1 uc007yrq.2 uc007yrq.3 uc007yrq.1 uc007yrq.2 uc007yrq.3 
ENSMUST00000232440.2 4930579D07Rik ENSMUST00000232440.2 4930579D07Rik (from geneSymbol) ENSMUST00000232440.1 uc289grj.1 uc289grj.2 uc289grj.1 uc289grj.2 
ENSMUST00000232443.2 Gm49698 ENSMUST00000232443.2 Gm49698 (from geneSymbol) BC099486 ENSMUST00000232443.1 uc288fhn.1 uc288fhn.2 uc288fhn.1 uc288fhn.2 
ENSMUST00000232444.3 Gm49700 ENSMUST00000232444.3 Gm49700 (from geneSymbol) ENSMUST00000232444.1 ENSMUST00000232444.2 uc288fhv.1 uc288fhv.2 uc288fhv.3 uc288fhv.1 uc288fhv.2 uc288fhv.3 
ENSMUST00000232448.2 Dppa2 ENSMUST00000232448.2 Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes. (from UniProt Q9CWH0) AK145760 DPPA2_MOUSE ENSMUST00000232448.1 Phsecrg1 Q9CWH0 uc289eya.1 uc289eya.2 Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes. Interacts with DPPA4. Nucleus Not detected in adult tissues. Expressed in 4-cell embryo, morula and blastocyst. At 7.5 dpc, detected in the epiblast. At 10.0 dpc, expressed in the primordial germ cells. Expression decreases at 12.0 dpc in the embryonic gonads. At 14.5 dpc, expression is restricted to testis. 6 days after birth, still detected in primitive type A spermatogonia. Expressed in undifferentiated embryonic stem cells, but expression rapidly decreases upon differentiation. Mutant animals show survival rates similar to wild-type until 16.5 dpc. Then mortality increases and no animals survive beyond weaning age. At 18.5 dpc, the lungs of mutants mice show a thicker mesenchyme and smaller alveolar space than those of wild-type animals. chromatin binding nucleus stem cell population maintenance regulation of histone methylation lung-associated mesenchyme development positive regulation of stem cell proliferation uc289eya.1 uc289eya.2 
ENSMUST00000232465.3 9030404E10Rik ENSMUST00000232465.3 RIKEN cDNA 9030404E10 gene (from RefSeq NR_045878.1) ENSMUST00000232465.1 ENSMUST00000232465.2 NR_045878 uc007ywk.1 uc007ywk.2 uc007ywk.3 uc007ywk.1 uc007ywk.2 uc007ywk.3 
ENSMUST00000232467.2 4930553J12Rik ENSMUST00000232467.2 RIKEN cDNA 4930553J12 gene (from RefSeq NR_138570.1) ENSMUST00000232467.1 NR_138570 uc289fvp.1 uc289fvp.2 uc289fvp.1 uc289fvp.2 
ENSMUST00000232472.2 Gm29737 ENSMUST00000232472.2 Gm29737 (from geneSymbol) ENSMUST00000232472.1 uc288fgd.1 uc288fgd.2 uc288fgd.1 uc288fgd.2 
ENSMUST00000232478.2 7120432I05Rik ENSMUST00000232478.2 7120432I05Rik (from geneSymbol) ENSMUST00000232478.1 uc289frf.1 uc289frf.2 uc289frf.1 uc289frf.2 
ENSMUST00000232483.2 Gm10479 ENSMUST00000232483.2 Gm10479 (from geneSymbol) BC024416 ENSMUST00000232483.1 uc288fhm.1 uc288fhm.2 uc288fhm.1 uc288fhm.2 
ENSMUST00000232488.3 Gm49778 ENSMUST00000232488.3 Gm49778 (from geneSymbol) ENSMUST00000232488.1 ENSMUST00000232488.2 uc289hhw.1 uc289hhw.2 uc289hhw.3 uc289hhw.1 uc289hhw.2 uc289hhw.3 
ENSMUST00000232512.2 Gm49705 ENSMUST00000232512.2 Gm49705 (from geneSymbol) AK140977 ENSMUST00000232512.1 uc289eaq.1 uc289eaq.2 uc289eaq.1 uc289eaq.2 
ENSMUST00000232518.3 D16Ertd519e ENSMUST00000232518.3 DNA segment, Chr 16, ERATO Doi 519, expressed (from RefSeq NR_040474.1) ENSMUST00000232518.1 ENSMUST00000232518.2 NR_040474 uc007zqv.1 uc007zqv.2 uc007zqv.3 uc007zqv.1 uc007zqv.2 uc007zqv.3 
ENSMUST00000232530.2 Gm49588 ENSMUST00000232530.2 Gm49588 (from geneSymbol) ENSMUST00000232530.1 uc289dej.1 uc289dej.2 uc289dej.1 uc289dej.2 
ENSMUST00000232537.2 Gm49658 ENSMUST00000232537.2 Gm49658 (from geneSymbol) ENSMUST00000232537.1 uc289fmo.1 uc289fmo.2 uc289fmo.1 uc289fmo.2 
ENSMUST00000232549.2 4930500H12Rik ENSMUST00000232549.2 4930500H12Rik (from geneSymbol) AK133038 ENSMUST00000232549.1 uc289flo.1 uc289flo.2 uc289flo.1 uc289flo.2 
ENSMUST00000232563.2 Gm49691 ENSMUST00000232563.2 Gm49691 (from geneSymbol) ENSMUST00000232563.1 uc289how.1 uc289how.2 uc289how.1 uc289how.2 
ENSMUST00000232581.2 Top3b ENSMUST00000232581.2 topoisomerase (DNA) III beta, transcript variant 2 (from RefSeq NM_001326576.1) ENSMUST00000232581.1 NM_001326576 Q9Z321 TOP3B_MOUSE Top3b1 uc007yjj.1 uc007yjj.2 uc007yjj.3 uc007yjj.4 Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity. Reaction=ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.; EC=5.6.2.1; Evidence= Highly expressed in testis. Belongs to the type IA topoisomerase family. condensed chromosome DNA binding DNA topoisomerase activity DNA topoisomerase type I activity nucleus DNA topological change chromosome segregation isomerase activity uc007yjj.1 uc007yjj.2 uc007yjj.3 uc007yjj.4 
ENSMUST00000232586.2 Gm32312 ENSMUST00000232586.2 Gm32312 (from geneSymbol) AK041870 ENSMUST00000232586.1 uc289dwh.1 uc289dwh.2 uc289dwh.1 uc289dwh.2 
ENSMUST00000232596.3 2210020O09Rik ENSMUST00000232596.3 2210020O09Rik (from geneSymbol) AK008758 ENSMUST00000232596.1 ENSMUST00000232596.2 uc289eda.1 uc289eda.2 uc289eda.3 uc289eda.1 uc289eda.2 uc289eda.3 
ENSMUST00000232598.2 Gm4988 ENSMUST00000232598.2 Gm4988 (from geneSymbol) ENSMUST00000232598.1 uc292oju.1 uc292oju.2 uc292oju.1 uc292oju.2 
ENSMUST00000232600.2 Cd200l2 ENSMUST00000232600.2 Cd200l2 (from geneSymbol) A0A077KA19 A0A077KA19_MOUSE AB853321 Cd200l2 ENSMUST00000232600.1 Gm17783 isec2 uc056zcc.1 uc056zcc.2 membrane integral component of membrane uc056zcc.1 uc056zcc.2 
ENSMUST00000232607.3 Gm29805 ENSMUST00000232607.3 predicted gene, 29805 (from RefSeq NR_105054.1) ENSMUST00000232607.1 ENSMUST00000232607.2 NR_105054 uc007zzc.1 uc007zzc.2 uc007zzc.3 uc007zzc.1 uc007zzc.2 uc007zzc.3 
ENSMUST00000232608.2 Gm49695 ENSMUST00000232608.2 Gm49695 (from geneSymbol) ENSMUST00000232608.1 uc289eag.1 uc289eag.2 uc289eag.1 uc289eag.2 
ENSMUST00000232609.2 Gm38551 ENSMUST00000232609.2 Gm38551 (from geneSymbol) ENSMUST00000232609.1 uc289hen.1 uc289hen.2 uc289hen.1 uc289hen.2 
ENSMUST00000232626.2 Gm49784 ENSMUST00000232626.2 Gm49784 (from geneSymbol) AK138419 ENSMUST00000232626.1 uc289hit.1 uc289hit.2 uc289hit.1 uc289hit.2 
ENSMUST00000232628.2 Gm49733 ENSMUST00000232628.2 Gm49733 (from geneSymbol) ENSMUST00000232628.1 uc033gyv.1 uc033gyv.2 uc033gyv.3 uc033gyv.1 uc033gyv.2 uc033gyv.3 
ENSMUST00000232647.3 Cldn20 ENSMUST00000232647.3 claudin 20 (from RefSeq NM_001101560.1) ENSMUST00000232647.1 ENSMUST00000232647.2 NM_001101560 uc289grc.1 uc289grc.2 uc289grc.3 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is identified in retinal pigment epithelium (RPE) and analysis of the RPE transcriptome reveals that this gene expression appears late during development of chick embryo. [provided by RefSeq, Aug 2010]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## uc289grc.1 uc289grc.2 uc289grc.3 
ENSMUST00000232651.2 Gm49575 ENSMUST00000232651.2 Gm49575 (from geneSymbol) ENSMUST00000232651.1 uc289fdt.1 uc289fdt.2 uc289fdt.1 uc289fdt.2 
ENSMUST00000232652.3 Gm36001 ENSMUST00000232652.3 predicted gene, 36001 (from RefSeq NR_167897.1) ENSMUST00000232652.1 ENSMUST00000232652.2 NR_167897 uc289fxi.1 uc289fxi.2 uc289fxi.3 uc289fxi.1 uc289fxi.2 uc289fxi.3 
ENSMUST00000232657.2 Gm49580 ENSMUST00000232657.2 predicted gene, 49580 (from RefSeq NR_188876.1) ENSMUST00000232657.1 NR_188876 uc289daz.1 uc289daz.2 uc289daz.1 uc289daz.2 
ENSMUST00000232664.2 Krtap13-24 ENSMUST00000232664.2 predicted gene, 20741 (from RefSeq NR_045150.1) A0A338P708 A0A338P708_MOUSE ENSMUST00000232664.1 Gm20741 NR_045150 uc029syo.1 uc029syo.2 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the PMG family. uc029syo.1 uc029syo.2 
ENSMUST00000232677.2 Gm49711 ENSMUST00000232677.2 Belongs to the bacterial ribosomal protein bS6 family. (from UniProt A0A338P7H3) A0A338P7H3 A0A338P7H3_MOUSE AK087806 ENSMUST00000232677.1 Gm49711 uc289gdz.1 uc289gdz.2 Belongs to the bacterial ribosomal protein bS6 family. structural constituent of ribosome ribosome translation rRNA binding uc289gdz.1 uc289gdz.2 
ENSMUST00000232678.2 Gm49674 ENSMUST00000232678.2 Gm49674 (from geneSymbol) ENSMUST00000232678.1 uc289fms.1 uc289fms.2 uc289fms.1 uc289fms.2 
ENSMUST00000232692.3 A730006G06Rik ENSMUST00000232692.3 RIKEN cDNA A730006G06 gene (from RefSeq NR_110485.1) ENSMUST00000232692.1 ENSMUST00000232692.2 NR_110485 uc008cwq.1 uc008cwq.2 uc008cwq.3 uc008cwq.1 uc008cwq.2 uc008cwq.3 
ENSMUST00000232698.2 Gm34883 ENSMUST00000232698.2 Gm34883 (from geneSymbol) ENSMUST00000232698.1 uc289gxz.1 uc289gxz.2 uc289gxz.1 uc289gxz.2 
ENSMUST00000232709.2 Crisp2 ENSMUST00000232709.2 May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. (from UniProt P16563) BC049615 CRIS2_MOUSE ENSMUST00000232709.1 P16563 Tpx-1 Tpx1 uc289lep.1 uc289lep.2 May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. Interacts with NSUN4 isoform 3. Secreted Testis. Belongs to the CRISP family. extracellular region extracellular space cell-cell adhesion uc289lep.1 uc289lep.2 
ENSMUST00000232711.2 Gm49874 ENSMUST00000232711.2 Gm49874 (from geneSymbol) ENSMUST00000232711.1 uc289ixk.1 uc289ixk.2 uc289ixk.1 uc289ixk.2 
ENSMUST00000232713.2 Gm49888 ENSMUST00000232713.2 Gm49888 (from geneSymbol) ENSMUST00000232713.1 uc289meu.1 uc289meu.2 uc289meu.1 uc289meu.2 
ENSMUST00000232718.2 Gm32432 ENSMUST00000232718.2 Gm32432 (from geneSymbol) ENSMUST00000232718.1 KY467768 uc057kvz.1 uc057kvz.2 uc057kvz.3 uc057kvz.1 uc057kvz.2 uc057kvz.3 
ENSMUST00000232732.2 Mea1 ENSMUST00000232732.2 male enhanced antigen 1, transcript variant 3 (from RefSeq NM_001277310.1) ENSMUST00000232732.1 MEA1_MOUSE Mea NM_001277310 Q64327 Q793G4 uc033heg.1 uc033heg.2 uc033heg.3 May play an important role in spermatogenesis and/or testis development. Highly expressed in testis. Transcripts can be found in primary and secondary spermatocytes, and spermatids, but the protein itself is only detected in spermatids. No expression in Leydig cells, spermatogonia, or sperm. Very weak expression in the heart, kidney, spleen, thymus and ovary. Expressed as early as day 6 postpartum (dpp), with higher expression in the adult testis. Was originally thought to be the H-Y antigen. It is uncertain whether Met-1 or Met-11 is the initiator. cytoplasm multicellular organism development spermatogenesis cell differentiation uc033heg.1 uc033heg.2 uc033heg.3 
ENSMUST00000232734.2 Gm49889 ENSMUST00000232734.2 Gm49889 (from geneSymbol) ENSMUST00000232734.1 uc289iyj.1 uc289iyj.2 uc289iyj.1 uc289iyj.2 
ENSMUST00000232737.3 Gm4566 ENSMUST00000232737.3 predicted gene 4566 (from RefSeq NR_028023.1) ENSMUST00000232737.1 ENSMUST00000232737.2 NR_028023 uc012aws.1 uc012aws.2 uc012aws.3 uc012aws.4 uc012aws.1 uc012aws.2 uc012aws.3 uc012aws.4 
ENSMUST00000232739.2 Gm44501 ENSMUST00000232739.2 Gm44501 (from geneSymbol) A0A3B2WCV0 A0A3B2WCV0_MOUSE AB306983 ENSMUST00000232739.1 Gm44501 uc289lel.1 uc289lel.2 pheromone activity extracellular space membrane integral component of membrane uc289lel.1 uc289lel.2 
ENSMUST00000232741.3 Gm49870 ENSMUST00000232741.3 Gm49870 (from geneSymbol) ENSMUST00000232741.1 ENSMUST00000232741.2 uc289mjq.1 uc289mjq.2 uc289mjq.3 uc289mjq.1 uc289mjq.2 uc289mjq.3 
ENSMUST00000232743.2 Esp38 ENSMUST00000232743.2 Esp38 (from geneSymbol) A0A3B2W3Y6 A0A3B2W3Y6_MOUSE AB307019 ENSMUST00000232743.1 Esp38 uc029thv.1 uc029thv.2 uc029thv.3 pheromone activity extracellular space biological_process membrane integral component of membrane uc029thv.1 uc029thv.2 uc029thv.3 
ENSMUST00000232745.2 Gm36594 ENSMUST00000232745.2 Gm36594 (from geneSymbol) AK048835 ENSMUST00000232745.1 uc289mnw.1 uc289mnw.2 uc289mnw.1 uc289mnw.2 
ENSMUST00000232747.2 Gm49915 ENSMUST00000232747.2 Gm49915 (from geneSymbol) ENSMUST00000232747.1 uc289lxb.1 uc289lxb.2 uc289lxb.1 uc289lxb.2 
ENSMUST00000232749.2 Gm49880 ENSMUST00000232749.2 Gm49880 (from geneSymbol) AB049456 ENSMUST00000232749.1 uc289mui.1 uc289mui.2 uc289mui.1 uc289mui.2 
ENSMUST00000232754.3 Gm41600 ENSMUST00000232754.3 predicted gene, 41600 (from RefSeq NR_169078.1) ENSMUST00000232754.1 ENSMUST00000232754.2 NR_169078 uc289lwo.1 uc289lwo.2 uc289lwo.3 uc289lwo.1 uc289lwo.2 uc289lwo.3 
ENSMUST00000232756.2 Gm49807 ENSMUST00000232756.2 Gm49807 (from geneSymbol) AK136010 ENSMUST00000232756.1 uc289gxv.1 uc289gxv.2 uc289gxv.1 uc289gxv.2 
ENSMUST00000232764.2 Gm49835 ENSMUST00000232764.2 Gm49835 (from geneSymbol) A0A3B2WCP9 A0A3B2WCP9_MOUSE ENSMUST00000232764.1 Gm49835 uc289ldu.1 uc289ldu.2 pheromone activity extracellular space uc289ldu.1 uc289ldu.2 
ENSMUST00000232781.2 Pnpla1os ENSMUST00000232781.2 Pnpla1os (from geneSymbol) AK029928 ENSMUST00000232781.1 uc289jcn.1 uc289jcn.2 uc289jcn.1 uc289jcn.2 
ENSMUST00000232782.2 Gm49878 ENSMUST00000232782.2 Gm49878 (from geneSymbol) ENSMUST00000232782.1 uc289mtp.1 uc289mtp.2 uc289mtp.1 uc289mtp.2 
ENSMUST00000232793.2 ENSMUSG00000121815 ENSMUST00000232793.2 ENSMUSG00000121815 (from geneSymbol) AK014206 ENSMUST00000232793.1 uc289hpe.1 uc289hpe.2 uc289hpe.1 uc289hpe.2 
ENSMUST00000232800.2 Gm32509 ENSMUST00000232800.2 Gm32509 (from geneSymbol) AK016518 ENSMUST00000232800.1 uc289gnk.1 uc289gnk.2 uc289gnk.1 uc289gnk.2 
ENSMUST00000232806.2 Gm57191 ENSMUST00000232806.2 Gm57191 (from geneSymbol) ENSMUST00000232806.1 uc291lpc.1 uc291lpc.2 uc291lpc.1 uc291lpc.2 
ENSMUST00000232810.2 Vmn1r229 ENSMUST00000232810.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2A9) ENSMUST00000232810.1 Q8R2A9 Q8R2A9_MOUSE V1re1 Vmn1r229 uc289hnk.1 uc289hnk.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc289hnk.1 uc289hnk.2 
ENSMUST00000232827.2 Zfp983 ENSMUST00000232827.2 zinc finger protein 983, transcript variant 2 (from RefSeq NM_001357098.1) E9PUT0 E9PUT0_MOUSE ENSMUST00000232827.1 NM_001357098 Zfp983 uc008ard.1 uc008ard.2 uc008ard.3 uc008ard.4 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding cellular_component regulation of transcription, DNA-templated response to bacterium metal ion binding uc008ard.1 uc008ard.2 uc008ard.3 uc008ard.4 
ENSMUST00000232839.2 Gm49944 ENSMUST00000232839.2 Gm49944 (from geneSymbol) ENSMUST00000232839.1 uc289mmm.1 uc289mmm.2 uc289mmm.1 uc289mmm.2 
ENSMUST00000232841.2 Ptp4a1 ENSMUST00000232841.2 protein tyrosine phosphatase 4a1, transcript variant 4 (from RefSeq NM_001420788.1) ENSMUST00000232841.1 NM_001420788 O09097 O09154 Prl1 Q3UFU9 Q63739 TP4A1_MOUSE uc287gzy.1 uc287gzy.2 Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Inhibited by sodium orthovanadate and pentamidine. Homotrimer. Interacts with tubulin (By similarity). Interacts with ATF5. Cell membrane ; Lipid-anchor Early endosome Endoplasmic reticulum Cytoplasm Cytoplasm, cytoskeleton, spindle Nucleus Note=And mitotic spindle. Expressed in all tissues except heart and skeletal muscle, from 10.5 dpc to 18.5 dpc. Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus. Belongs to the protein-tyrosine phosphatase family. phosphoprotein phosphatase activity protein tyrosine phosphatase activity prenylated protein tyrosine phosphatase activity nucleus cytoplasm endosome early endosome endoplasmic reticulum spindle cytoskeleton plasma membrane protein dephosphorylation cell cycle multicellular organism development protein tyrosine/serine/threonine phosphatase activity cytoplasmic side of plasma membrane membrane dephosphorylation hydrolase activity phosphatase activity positive regulation of cell migration peptidyl-tyrosine dephosphorylation uc287gzy.1 uc287gzy.2 
ENSMUST00000232846.2 Gm49802 ENSMUST00000232846.2 Gm49802 (from geneSymbol) ENSMUST00000232846.1 uc289ivr.1 uc289ivr.2 uc289ivr.1 uc289ivr.2 
ENSMUST00000232857.3 Gm49959 ENSMUST00000232857.3 Gm49959 (from geneSymbol) ENSMUST00000232857.1 ENSMUST00000232857.2 uc289hae.1 uc289hae.2 uc289hae.3 uc289hae.1 uc289hae.2 uc289hae.3 
ENSMUST00000232873.2 Snrpc ENSMUST00000232873.2 Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (from UniProt Q62241) AK137213 ENSMUST00000232873.1 Q62241 RU1C_MOUSE Snrp1c Snrpc uc008bps.1 uc008bps.2 uc008bps.3 uc008bps.4 Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA (By similarity). Interacts (via N-terminus) with TIA1 (via C- terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites (By similarity). Nucleus Widely expressed. In the testis, expressed in somatic and germinal testicular cells but not in elongated spermatids. First detected in the testis 18 days after birth. Levels increase successively between days 21-28. On day 42, levels decrease. Belongs to the U1 small nuclear ribonucleoprotein C family. commitment complex spliceosomal snRNP assembly mRNA 5'-splice site recognition mRNA splicing, via spliceosome nucleic acid binding RNA binding single-stranded RNA binding mRNA binding nucleus nucleoplasm U1 snRNP zinc ion binding Cajal body U1 snRNA binding pre-mRNA 5'-splice site binding protein homodimerization activity metal ion binding U2-type prespliceosome U1 snRNP binding uc008bps.1 uc008bps.2 uc008bps.3 uc008bps.4 
ENSMUST00000232878.2 Gm49897 ENSMUST00000232878.2 Gm49897 (from geneSymbol) BC130031 ENSMUST00000232878.1 uc289iwo.1 uc289iwo.2 uc289iwo.1 uc289iwo.2 
ENSMUST00000232880.2 Vmn2r55 ENSMUST00000232880.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A3B2W3J6) A0A3B2W3J6 A0A3B2W3J6_MOUSE AB919108 ENSMUST00000232880.1 Vmn2r55 uc291lpd.1 uc291lpd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc291lpd.1 uc291lpd.2 
ENSMUST00000232883.3 Gm49887 ENSMUST00000232883.3 Gm49887 (from geneSymbol) ENSMUST00000232883.1 ENSMUST00000232883.2 uc289mea.1 uc289mea.2 uc289mea.3 uc289mea.1 uc289mea.2 uc289mea.3 
ENSMUST00000232887.2 ENSMUSG00000121850 ENSMUST00000232887.2 ENSMUSG00000121850 (from geneSymbol) ENSMUST00000232887.1 uc289iut.1 uc289iut.2 uc289iut.1 uc289iut.2 
ENSMUST00000232893.2 Gm49949 ENSMUST00000232893.2 Gm49949 (from geneSymbol) ENSMUST00000232893.1 uc289mmy.1 uc289mmy.2 uc289mmy.1 uc289mmy.2 
ENSMUST00000232907.3 Snhg20 ENSMUST00000232907.3 Snhg20 (from geneSymbol) BC037520 ENSMUST00000232907.1 ENSMUST00000232907.2 uc288dwa.1 uc288dwa.2 uc288dwa.3 uc288dwa.1 uc288dwa.2 uc288dwa.3 
ENSMUST00000232912.2 Vmn2r16 ENSMUST00000232912.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A3B2WCY4) A0A3B2WCY4 A0A3B2WCY4_MOUSE ENSMUST00000232912.1 Vmn2r16 uc290ybp.1 uc290ybp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc290ybp.1 uc290ybp.2 
ENSMUST00000232919.2 Gm49886 ENSMUST00000232919.2 Gm49886 (from geneSymbol) ENSMUST00000232919.1 uc289iyh.1 uc289iyh.2 uc289iyh.1 uc289iyh.2 
ENSMUST00000232926.2 A330072L02Rik ENSMUST00000232926.2 A330072L02Rik (from geneSymbol) AK039611 ENSMUST00000232926.1 uc008dex.1 uc008dex.2 uc008dex.1 uc008dex.2 
ENSMUST00000232932.2 Gscdt ENSMUST00000232932.2 Gscdt (from geneSymbol) ENSMUST00000232932.1 LF203962 uc288ixj.1 uc288ixj.2 uc288ixj.1 uc288ixj.2 
ENSMUST00000232955.2 Esp24 ENSMUST00000232955.2 exocrine gland secreted peptide 24 (from RefSeq NM_001256050.1) A8R0V6 A8R0V6_MOUSE ENSMUST00000232955.1 Esp24 Gm21947 NM_001256050 uc029ths.1 uc029ths.2 pheromone activity extracellular space biological_process uc029ths.1 uc029ths.2 
ENSMUST00000232963.2 Gm36487 ENSMUST00000232963.2 Gm36487 (from geneSymbol) AK043788 ENSMUST00000232963.1 uc289mnm.1 uc289mnm.2 uc289mnm.1 uc289mnm.2 
ENSMUST00000232967.2 A730049N16Rik ENSMUST00000232967.2 A730049N16Rik (from geneSymbol) AK043040 ENSMUST00000232967.1 uc289mnr.1 uc289mnr.2 uc289mnr.1 uc289mnr.2 
ENSMUST00000232970.2 4930553M12Rik ENSMUST00000232970.2 4930553M12Rik (from geneSymbol) AK016108 ENSMUST00000232970.1 uc290nsc.1 uc290nsc.2 uc290nsc.1 uc290nsc.2 
ENSMUST00000232974.2 Lhfpl5 ENSMUST00000232974.2 In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation. (from UniProt Q4KL25) AK020670 B2KF30 ENSMUST00000232974.1 LHPL5_MOUSE Lhfpl5 Q4KL25 Tmhs uc289jaq.1 uc289jaq.2 In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation. Found in a complex with TMIE and PCDH15 (PubMed:25467981). Interacts with PCDH15; this interaction is required for efficient localization to hair bundles (PubMed:23217710). Interacts with TOMT (PubMed:28504928). Cell membrane ; Multi-pass membrane protein Note=Efficient localization to the plasma membrane requires the presence of PCDH15. Brain, inner ear hair cells and vestibular neuroepithelia of the inner ear (PubMed:16459341, PubMed:23217710, PubMed:15905332). In inner ear, expressed in stereocilia in a punctate pattern and at the tip-link region (at protein level) (PubMed:16459341, PubMed:23217710, PubMed:15905332). Strongly expressed in brain (PubMed:26964900). Weakly expressed in heart, testis and intestine (PubMed:26964900). Expressed in inner ear hair cells at 16.5 dpc. Expressed postnatally in inner and outer hair cells of the cochlear, as well as in vestibular hair cells. At the cochlear apex, levels are low at P1 and increased thereafter. After P7, hardly detectable at the protein level, while mRNA levels remains high in adult hair cells. Note=Defects in Lhfpl5 are the cause of the hurry-scurry (hscy) phenotype which is characterized by rapid circling behavior, frequent shaking of head from side to side, deafness and vestibular dysfunction. Belongs to the LHFP family. protein binding plasma membrane ion transport sensory perception of sound membrane integral component of membrane apical plasma membrane stereocilium bundle stereocilium tip detection of mechanical stimulus involved in sensory perception of sound auditory receptor cell stereocilium organization uc289jaq.1 uc289jaq.2 
ENSMUST00000232977.2 Pxt1 ENSMUST00000232977.2 Pxt1 (from geneSymbol) A0A3B2WCX9 A0A3B2WCX9_MOUSE BC100437 ENSMUST00000232977.1 Pxt1 uc289jcu.1 uc289jcu.2 uc289jcu.1 uc289jcu.2 
ENSMUST00000232983.2 Gm22146 ENSMUST00000232983.2 Gm22146 (from geneSymbol) ENSMUST00000232983.1 uc289jab.1 uc289jab.2 uc289jab.1 uc289jab.2 
ENSMUST00000232991.3 Gm49891 ENSMUST00000232991.3 Gm49891 (from geneSymbol) ENSMUST00000232991.1 ENSMUST00000232991.2 uc290nse.1 uc290nse.2 uc290nse.3 uc290nse.1 uc290nse.2 uc290nse.3 
ENSMUST00000233003.2 Gng5c ENSMUST00000233003.2 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (from UniProt A0A3B2WD42) A0A3B2WD42 A0A3B2WD42_MOUSE ENSMUST00000233003.1 Gm4356 Gng5c LF205057 uc289jbk.1 uc289jbk.2 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units; alpha, beta and gamma. Cell membrane ipid-anchor ; Cytoplasmic side mbrane ; Lipid-anchor ; Cytoplasmic side Belongs to the G protein gamma family. molecular_function GTPase activity cellular_component heterotrimeric G-protein complex plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane uc289jbk.1 uc289jbk.2 
ENSMUST00000233005.2 Gm32358 ENSMUST00000233005.2 Gm32358 (from geneSymbol) ENSMUST00000233005.1 uc289gne.1 uc289gne.2 uc289gne.1 uc289gne.2 
ENSMUST00000233013.2 Gm49883 ENSMUST00000233013.2 Gm49883 (from geneSymbol) AK044495 ENSMUST00000233013.1 uc289mup.1 uc289mup.2 uc289mup.1 uc289mup.2 
ENSMUST00000233023.3 ENSMUSG00000121837 ENSMUST00000233023.3 ENSMUSG00000121837 (from geneSymbol) AF011421 ENSMUST00000233023.1 ENSMUST00000233023.2 uc288tpm.1 uc288tpm.2 uc288tpm.3 uc288tpm.1 uc288tpm.2 uc288tpm.3 
ENSMUST00000233025.2 Gm49806 ENSMUST00000233025.2 Gm49806 (from geneSymbol) ENSMUST00000233025.1 uc289gxq.1 uc289gxq.2 uc289gxq.1 uc289gxq.2 
ENSMUST00000233049.2 Gm10512 ENSMUST00000233049.2 predicted gene 10512 (from RefSeq NR_033458.1) ENSMUST00000233049.1 NR_033458 uc012akk.1 uc012akk.2 uc012akk.3 uc012akk.1 uc012akk.2 uc012akk.3 
ENSMUST00000233057.2 Emilin2 ENSMUST00000233057.2 elastin microfibril interfacer 2, transcript variant 1 (from RefSeq NM_145158.4) EMIL2_MOUSE ENSMUST00000233057.1 NM_145158 Q8K482 uc008dme.1 uc008dme.2 uc008dme.3 May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. Major component of the cochlear basilar membrane (BM) which may contribute to the developmental assembly or function of the BM. Homotrimer associated through a moderately stable interaction of the C-terminal globular C1q domains, allowing the nucleation of the triple helix and then a further quaternary assembly to higher-order polymers via intermolecular disulfide bonds (By similarity). Interacts with EMILIN1. Secreted, extracellular space, extracellular matrix. Note=Found mainly at the interface between amorphous elastin and microfibrils. Highest levels are present in cochlea of P8 pups, followed by modest levels in adult heart and lung, and much lower levels in forebrain, brainstem, cerebellum and hypothalamus. Very low levels detected in muscle, liver, kidney and eye. Low levels detected in cochlea in neonatal pups at P1. Levels increased 2-fold by P5 and rose further to 16-fold at P13. Expression declined somewhat in adult mice. At 9.5 dpc, as during all stages of development, it is strongly expressed in the neural fold, the limbbuds and the heart. extracellular region collagen trimer extracellular space cell adhesion extracellular matrix constituent conferring elasticity uc008dme.1 uc008dme.2 uc008dme.3 
ENSMUST00000233069.2 Dino ENSMUST00000233069.2 Dino (from geneSymbol) AK006261 ENSMUST00000233069.1 uc289jfj.1 uc289jfj.2 uc289jfj.1 uc289jfj.2 
ENSMUST00000233072.2 Gm49922 ENSMUST00000233072.2 Gm49922 (from geneSymbol) ENSMUST00000233072.1 uc289mrz.1 uc289mrz.2 uc289mrz.1 uc289mrz.2 
ENSMUST00000233076.2 6330415G19Rik ENSMUST00000233076.2 RIKEN cDNA 6330415G19 gene, transcript variant 1 (from RefSeq NR_126484.1) ENSMUST00000233076.1 NR_126484 uc056zdn.1 uc056zdn.2 uc056zdn.3 uc056zdn.1 uc056zdn.2 uc056zdn.3 
ENSMUST00000233091.2 Gm49839 ENSMUST00000233091.2 Gm49839 (from geneSymbol) AK136659 ENSMUST00000233091.1 uc289jad.1 uc289jad.2 uc289jad.1 uc289jad.2 
ENSMUST00000233094.2 1700063J08Rik ENSMUST00000233094.2 1700063J08Rik (from geneSymbol) AK006872 ENSMUST00000233094.1 uc289jcw.1 uc289jcw.2 uc289jcw.1 uc289jcw.2 
ENSMUST00000233110.2 Gm49872 ENSMUST00000233110.2 Gm49872 (from geneSymbol) AK040043 ENSMUST00000233110.1 uc289lgq.1 uc289lgq.2 uc289lgq.1 uc289lgq.2 
ENSMUST00000233116.2 1600002D24Rik ENSMUST00000233116.2 1600002D24Rik (from geneSymbol) AK037512 ENSMUST00000233116.1 uc289gky.1 uc289gky.2 uc289gky.1 uc289gky.2 
ENSMUST00000233130.2 Gm36201 ENSMUST00000233130.2 predicted gene, 36201 (from RefSeq NR_155516.1) ENSMUST00000233130.1 NR_155516 uc289mmg.1 uc289mmg.2 uc289mmg.1 uc289mmg.2 
ENSMUST00000233133.2 Esp22 ENSMUST00000233133.2 Pheromone produced by juveniles which activates a small number of vomeronasal organ sensory neurons and exhibits a powerful inhibitory effect on adult male mating behavior. (from UniProt A8R0V4) A8R0V4 ENSMUST00000233133.1 ESP22_MOUSE Esp22 uc289ldb.1 uc289ldb.2 Pheromone produced by juveniles which activates a small number of vomeronasal organ sensory neurons and exhibits a powerful inhibitory effect on adult male mating behavior. Secreted Note=Secreted from the lacrimal gland into tears. Expressed in acinar cells of the lacrimal gland from where it is secreted into tears. Not detected in a range of other tissues tested including other exocrine glands, internal organs and sensory epithelia. Expressed maximally between 2 and 3 weeks of age. Levels decrease sharply after 4 weeks around puberty. Expression is 50- fold higher in juveniles than adults with similar levels in male and female juveniles. Not expressed in castrated or ovariectomized adults. Highly expressed in juveniles of strains BALB/C and C56BL/5 but expression is not detected in juveniles of strains CBA or C3H/He. Belongs to the exocrine gland-secreted peptide family. pheromone activity extracellular region extracellular space behavior negative regulation of male mating behavior uc289ldb.1 uc289ldb.2 
ENSMUST00000233136.2 Rrp36 ENSMUST00000233136.2 ribosomal RNA processing 36, transcript variant 1 (from RefSeq NM_144857.2) A0A3B2WB30 A0A3B2WB30_MOUSE ENSMUST00000233136.1 NM_144857 Rrp36 uc289lnw.1 uc289lnw.2 Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway. Associates with 90S and pre-40S pre-ribosomal particles. Nucleus, nucleolus Belongs to the RRP36 family. cleavage involved in rRNA processing nucleus nucleolus rRNA processing ribosome biogenesis uc289lnw.1 uc289lnw.2 
ENSMUST00000233158.2 Zfp53 ENSMUST00000233158.2 zinc finger protein 53 (from RefSeq NM_013843.3) ENSMUST00000233158.1 KRAZ1 NM_013843 Q9Z117 Q9Z117_MOUSE Zfp118 Zfp53 uc008aqz.1 uc008aqz.2 uc008aqz.3 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding protein binding regulation of transcription, DNA-templated metal ion binding uc008aqz.1 uc008aqz.2 uc008aqz.3 
ENSMUST00000233166.2 Gm49847 ENSMUST00000233166.2 Gm49847 (from geneSymbol) ENSMUST00000233166.1 uc289leh.1 uc289leh.2 uc289leh.1 uc289leh.2 
ENSMUST00000233175.2 Gm49906 ENSMUST00000233175.2 Gm49906 (from geneSymbol) ENSMUST00000233175.1 uc289lve.1 uc289lve.2 uc289lve.1 uc289lve.2 
ENSMUST00000233181.2 C230013L11Rik ENSMUST00000233181.2 C230013L11Rik (from geneSymbol) ENSMUST00000233181.1 uc056zdx.1 uc056zdx.2 uc056zdx.3 uc056zdx.1 uc056zdx.2 uc056zdx.3 
ENSMUST00000233185.2 Gm41556 ENSMUST00000233185.2 Gm41556 (from geneSymbol) ENSMUST00000233185.1 uc289jeu.1 uc289jeu.2 uc289jeu.1 uc289jeu.2 
ENSMUST00000233197.2 Kctd20 ENSMUST00000233197.2 potassium channel tetramerisation domain containing 20, transcript variant 4 (from RefSeq NM_001356300.2) ENSMUST00000233197.1 KCD20_MOUSE NM_001356300 Q3TKH8 Q5U5Z7 Q8CDD8 Q9CSC4 Q9CWT1 uc008brw.1 uc008brw.2 uc008brw.3 Promotes the phosphorylation of AKT family members. Interacts with AKT1; AKT2 and AKT3 (PubMed:24156551). Interacts with PPP2CA and PPP1CA (PubMed:24156551). Part of a complex containing MARK4 (By similarity). Cytoplasm Note=Colocalizes with BTBD10 in filamentous structures. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CDD8-1; Sequence=Displayed; Name=2; IsoId=Q8CDD8-2; Sequence=VSP_021279; Ubiquitously expressed. Sequence=BAE39167.1; Type=Erroneous initiation; Evidence=; protein binding cytoplasm positive regulation of phosphorylation uc008brw.1 uc008brw.2 uc008brw.3 
ENSMUST00000233201.2 Gm49838 ENSMUST00000233201.2 Gm49838 (from geneSymbol) AK029444 ENSMUST00000233201.1 uc289izy.1 uc289izy.2 uc289izy.1 uc289izy.2 
ENSMUST00000233218.3 Gm49895 ENSMUST00000233218.3 Gm49895 (from geneSymbol) AK030114 ENSMUST00000233218.1 ENSMUST00000233218.2 uc289mnv.1 uc289mnv.2 uc289mnv.3 uc289mnv.1 uc289mnv.2 uc289mnv.3 
ENSMUST00000233219.2 Gm49961 ENSMUST00000233219.2 Gm49961 (from geneSymbol) ENSMUST00000233219.1 uc289gfz.1 uc289gfz.2 uc289gfz.1 uc289gfz.2 
ENSMUST00000233228.2 Gm49942 ENSMUST00000233228.2 Gm49942 (from geneSymbol) AK045866 ENSMUST00000233228.1 uc289mmc.1 uc289mmc.2 uc289mmc.1 uc289mmc.2 
ENSMUST00000233237.2 Gm35692 ENSMUST00000233237.2 Gm35692 (from geneSymbol) AK053380 ENSMUST00000233237.1 uc289ljr.1 uc289ljr.2 uc289ljr.1 uc289ljr.2 
ENSMUST00000233244.2 Gm49934 ENSMUST00000233244.2 Gm49934 (from geneSymbol) ENSMUST00000233244.1 uc289hcs.1 uc289hcs.2 uc289hcs.1 uc289hcs.2 
ENSMUST00000233268.2 Gm49876 ENSMUST00000233268.2 Gm49876 (from geneSymbol) ENSMUST00000233268.1 uc289mtl.1 uc289mtl.2 uc289mtl.1 uc289mtl.2 
ENSMUST00000233271.3 Gm34567 ENSMUST00000233271.3 Gm34567 (from geneSymbol) AK049862 ENSMUST00000233271.1 ENSMUST00000233271.2 uc289heg.1 uc289heg.2 uc289heg.3 uc289heg.1 uc289heg.2 uc289heg.3 
ENSMUST00000233275.2 Gm49901 ENSMUST00000233275.2 Gm49901 (from geneSymbol) ENSMUST00000233275.1 uc289luu.1 uc289luu.2 uc289luu.1 uc289luu.2 
ENSMUST00000233280.2 Vmn2r88 ENSMUST00000233280.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A3B2WCB0) A0A3B2WCB0 A0A3B2WCB0_MOUSE AF011413 ENSMUST00000233280.1 Vmn2r88 uc288tpd.1 uc288tpd.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc288tpd.1 uc288tpd.2 
ENSMUST00000233281.2 Zfp52 ENSMUST00000233281.2 zinc finger protein 52 (from RefSeq NM_144515.2) ENSMUST00000233281.1 NM_144515 Q8BJ45 Q8BJ45_MOUSE Zfp52 uc008arb.1 uc008arb.2 Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc008arb.1 uc008arb.2 
ENSMUST00000233284.2 Gm36200 ENSMUST00000233284.2 Gm36200 (from geneSymbol) AK142185 ENSMUST00000233284.1 uc289lkf.1 uc289lkf.2 uc289lkf.1 uc289lkf.2 
ENSMUST00000233287.2 Vmn2r54 ENSMUST00000233287.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A3B2W422) A0A3B2W422 A0A3B2W422_MOUSE ENSMUST00000233287.1 Vmn2r54 uc291lpb.1 uc291lpb.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc291lpb.1 uc291lpb.2 
ENSMUST00000233300.2 Gm49902 ENSMUST00000233300.2 Gm49902 (from geneSymbol) ENSMUST00000233300.1 uc289mos.1 uc289mos.2 uc289mos.1 uc289mos.2 
ENSMUST00000233302.3 Gm50433 ENSMUST00000233302.3 Gm50433 (from geneSymbol) BC023798 ENSMUST00000233302.1 ENSMUST00000233302.2 uc289hpa.1 uc289hpa.2 uc289hpa.3 uc289hpa.1 uc289hpa.2 uc289hpa.3 
ENSMUST00000233304.2 Vmn2r56 ENSMUST00000233304.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A3B2WBA1) A0A3B2WBA1 A0A3B2WBA1_MOUSE AB919109 ENSMUST00000233304.1 Vmn2r56 uc291lpf.1 uc291lpf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc291lpf.1 uc291lpf.2 
ENSMUST00000233313.2 ENSMUSG00000121736 ENSMUST00000233313.2 ENSMUSG00000121736 (from geneSymbol) ENSMUST00000233313.1 uc289ldw.1 uc289ldw.2 uc289ldw.1 uc289ldw.2 
ENSMUST00000233314.3 A230051N06Rik ENSMUST00000233314.3 RIKEN cDNA A230051N06 gene (from RefSeq NR_155493.1) ENSMUST00000233314.1 ENSMUST00000233314.2 NR_155493 uc008dbj.1 uc008dbj.2 uc008dbj.3 uc008dbj.4 uc008dbj.1 uc008dbj.2 uc008dbj.3 uc008dbj.4 
ENSMUST00000233317.2 Vmn2r76 ENSMUST00000233317.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A3B2WD31) A0A3B2WD31 A0A3B2WD31_MOUSE ENSMUST00000233317.1 Vmn2r76 uc291sih.1 uc291sih.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc291sih.1 uc291sih.2 
ENSMUST00000233331.3 Alyreffm1 ENSMUST00000233331.3 Alyreffm1 (from geneSymbol) 4931428L18Rik A0A087WNP0 A0A087WNP0_MOUSE BC172083 ENSMUST00000233331.1 ENSMUST00000233331.2 uc287haf.1 uc287haf.2 uc287haf.3 molecular_function nucleic acid binding RNA binding cellular_component biological_process uc287haf.1 uc287haf.2 uc287haf.3 
ENSMUST00000233338.2 Gm49946 ENSMUST00000233338.2 Gm49946 (from geneSymbol) ENSMUST00000233338.1 uc289lsk.1 uc289lsk.2 uc289lsk.1 uc289lsk.2 
ENSMUST00000233357.2 Gm49909 ENSMUST00000233357.2 Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. (from UniProt Q3THE2) BC131927 ENSMUST00000233357.1 ML12B_MOUSE Mrlc2 Myl12b Mylc2b Q3THE2 Q3TVH2 Q9CQL8 uc289mox.1 uc289mox.2 Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin heavy chain MYO19. Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment. This chain binds calcium. Sequence=BAE35646.1; Type=Frameshift; Evidence=; stress fiber calcium ion binding brush border regulation of cell shape myosin complex myosin II complex Z disc myosin heavy chain binding macromolecular complex apical part of cell metal ion binding cell cortex region uc289mox.1 uc289mox.2 
ENSMUST00000233367.2 Gm35290 ENSMUST00000233367.2 Gm35290 (from geneSymbol) ENSMUST00000233367.1 uc289ivs.1 uc289ivs.2 uc289ivs.1 uc289ivs.2 
ENSMUST00000233396.2 Gm49857 ENSMUST00000233396.2 Gm49857 (from geneSymbol) ENSMUST00000233396.1 uc289lff.1 uc289lff.2 uc289lff.1 uc289lff.2 
ENSMUST00000233404.2 Gm5094 ENSMUST00000233404.2 predicted gene 5094 (from RefSeq NR_188909.1) ENSMUST00000233404.1 NR_188909 uc289lwq.1 uc289lwq.2 uc289lwq.1 uc289lwq.2 
ENSMUST00000233405.2 Unc93a ENSMUST00000233405.2 Cell membrane ; Multi-pass membrane protein (from UniProt Q710D3) AJ422143 ENSMUST00000233405.1 Q710D3 UN93A_MOUSE uc289hci.1 uc289hci.2 Cell membrane ; Multi-pass membrane protein Belongs to the unc-93 family. molecular_function plasma membrane biological_process membrane integral component of membrane uc289hci.1 uc289hci.2 
ENSMUST00000233420.2 Tulp1 ENSMUST00000233420.2 Belongs to the TUB family. (from UniProt A0A3B2W4A1) A0A3B2W4A1 A0A3B2W4A1_MOUSE AF085681 ENSMUST00000233420.1 Tulp1 uc289izh.1 uc289izh.2 Belongs to the TUB family. uc289izh.1 uc289izh.2 
ENSMUST00000233431.2 Gm55377 ENSMUST00000233431.2 Gm55377 (from geneSymbol) AK144036 ENSMUST00000233431.1 uc289mtn.1 uc289mtn.2 uc289mtn.1 uc289mtn.2 
ENSMUST00000233443.2 C87487 ENSMUST00000233443.2 expressed sequence C87487, transcript variant 1 (from RefSeq NR_188907.1) ENSMUST00000233443.1 NR_188907 uc289gxo.1 uc289gxo.2 uc289gxo.1 uc289gxo.2 
ENSMUST00000233448.2 Gm49923 ENSMUST00000233448.2 Gm49923 (from geneSymbol) AK157677 ENSMUST00000233448.1 uc289mss.1 uc289mss.2 uc289mss.1 uc289mss.2 
ENSMUST00000233454.3 Gm11110 ENSMUST00000233454.3 Gm11110 (from geneSymbol) AK047366 ENSMUST00000233454.1 ENSMUST00000233454.2 uc008dec.1 uc008dec.2 uc008dec.3 uc008dec.4 uc008dec.5 uc008dec.1 uc008dec.2 uc008dec.3 uc008dec.4 uc008dec.5 
ENSMUST00000233463.2 1600022D10Rik ENSMUST00000233463.2 1600022D10Rik (from geneSymbol) AK005516 ENSMUST00000233463.1 uc289mpr.1 uc289mpr.2 uc289mpr.1 uc289mpr.2 
ENSMUST00000233465.2 Gm7072 ENSMUST00000233465.2 predicted gene 7072, transcript variant 2 (from RefSeq NM_001357992.1) A0A3B2WCF4 A0A3B2WCF4_MOUSE ENSMUST00000233465.1 Gm7072 NM_001357992 uc289hqi.1 uc289hqi.2 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc289hqi.1 uc289hqi.2 
ENSMUST00000233471.2 Gm49896 ENSMUST00000233471.2 Gm49896 (from geneSymbol) ENSMUST00000233471.1 uc289ltu.1 uc289ltu.2 uc289ltu.1 uc289ltu.2 
ENSMUST00000233479.2 E330032C10Rik ENSMUST00000233479.2 E330032C10Rik (from geneSymbol) AK054493 ENSMUST00000233479.1 uc008dni.1 uc008dni.2 uc008dni.3 uc008dni.1 uc008dni.2 uc008dni.3 
ENSMUST00000233498.2 Gm35883 ENSMUST00000233498.2 Gm35883 (from geneSymbol) ENSMUST00000233498.1 uc289jcg.1 uc289jcg.2 uc289jcg.1 uc289jcg.2 
ENSMUST00000233513.2 Esp1 ENSMUST00000233513.2 Esp1 (from geneSymbol) A0A3B2WD91 A0A3B2WD91_MOUSE AB194091 ENSMUST00000233513.1 Esp1 uc289leo.1 uc289leo.2 pheromone activity extracellular space membrane integral component of membrane uc289leo.1 uc289leo.2 
ENSMUST00000233514.3 Memo1 ENSMUST00000233514.3 mediator of cell motility 1 (from RefSeq NM_133771.2) ENSMUST00000233514.1 ENSMUST00000233514.2 MEMO1_MOUSE NM_133771 Q91VH6 uc012axb.1 uc012axb.2 uc012axb.3 May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Interacts with ERBB2 phosphorylated on 'Tyr-1249'. Belongs to the MEMO1 family. regulation of microtubule-based process peptide binding uc012axb.1 uc012axb.2 uc012axb.3 
ENSMUST00000233518.2 Gm49937 ENSMUST00000233518.2 Gm49937 (from geneSymbol) ENSMUST00000233518.1 uc289mlo.1 uc289mlo.2 uc289mlo.1 uc289mlo.2 
ENSMUST00000233521.3 Gm41611 ENSMUST00000233521.3 predicted gene, 41611 (from RefSeq NR_168105.1) ENSMUST00000233521.1 ENSMUST00000233521.2 NR_168105 uc008dlu.1 uc008dlu.2 uc008dlu.3 uc008dlu.1 uc008dlu.2 uc008dlu.3 
ENSMUST00000233527.3 Gm31143 ENSMUST00000233527.3 Gm31143 (from geneSymbol) ENSMUST00000233527.1 ENSMUST00000233527.2 uc289lvq.1 uc289lvq.2 uc289lvq.3 uc289lvq.1 uc289lvq.2 uc289lvq.3 
ENSMUST00000233559.2 Gm41609 ENSMUST00000233559.2 predicted gene, 41609 (from RefSeq NR_168098.1) ENSMUST00000233559.1 NR_168098 uc008dln.1 uc008dln.2 uc008dln.3 uc008dln.1 uc008dln.2 uc008dln.3 
ENSMUST00000233580.2 Twsg1 ENSMUST00000233580.2 May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development. (from UniProt Q9EP52) AF292033 ENSMUST00000233580.1 Q8CCB1 Q8CEM6 Q99K77 Q9EP52 Q9ERN7 TWSG1_MOUSE Tsg uc008dgq.1 uc008dgq.2 uc008dgq.3 uc008dgq.4 May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development. Interacts with CHRD and/or BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7. Secreted Expressed in lymph node, liver, kidney, and lung. Expression in the kidney was stronger in the medulla than in the cortex, particularly in the cells surrounding the medullary tubules. Expressed in growth plate cartilage of long bones, ribs, and digits and to a lesser extent also in the resting zone of the epiphysis, trabecular bone, and vertebral cartilage. Expression seems to be absent from other skeletal tissues including muscle, skin, and fibroblasts. Expressed at all embryonic stages examined. Expression was low and distribution was diffuse. At the primitive streak stage, detected in the extraembryonic region. Signal first appeared in the embryo during the neural plate stage. Stronger and more localized expression is seen after embryonic turning. Higher expression is seen in the branchial arch mesenchyme, the endoderm of the developing pharynx, all levels of the developing gut, the myotome compartment of the somites, and some regions of surface ectoderm. At 8.25 and 9.0 dpc expressed in head mesenchyme and ventral mesoderm. The N-terminal domain is sufficient to interact with BMP4. Embryonic lethality and sirenomelia were observed only in BMP null embryos in which one or two copies of TSG were also missing. When TSG and BMP7 are mutated, the siren phenotype results from the fusion of the limb buds in the ventroposterior midline owing to a paucity of posterior ventral mesoderm. Belongs to the twisted gastrulation protein family. ossification mesoderm formation negative regulation of cytokine production protein binding extracellular region extracellular space transforming growth factor beta receptor signaling pathway multicellular organism development salivary gland morphogenesis tissue development positive regulation of pathway-restricted SMAD protein phosphorylation hemopoiesis cell differentiation BMP signaling pathway positive regulation of BMP signaling pathway negative regulation of BMP signaling pathway forebrain development camera-type eye development negative regulation of osteoblast differentiation transforming growth factor beta binding negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of CD4-positive, alpha-beta T cell proliferation uc008dgq.1 uc008dgq.2 uc008dgq.3 uc008dgq.4 
ENSMUST00000233591.2 Gm49907 ENSMUST00000233591.2 Gm49907 (from geneSymbol) ENSMUST00000233591.1 uc289gnj.1 uc289gnj.2 uc289gnj.1 uc289gnj.2 
ENSMUST00000233597.2 Vmn1r227 ENSMUST00000233597.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A3B2W3R4) A0A3B2W3R4 A0A3B2W3R4_MOUSE ENSMUST00000233597.1 Vmn1r227 uc289hne.1 uc289hne.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc289hne.1 uc289hne.2 
ENSMUST00000233598.2 Gm49853 ENSMUST00000233598.2 Gm49853 (from geneSymbol) ENSMUST00000233598.1 uc289mgy.1 uc289mgy.2 uc289mgy.1 uc289mgy.2 
ENSMUST00000233599.2 Vmn2r18 ENSMUST00000233599.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A3B2WB67) A0A3B2WB67 A0A3B2WB67_MOUSE ENSMUST00000233599.1 Vmn2r18 uc291cej.1 uc291cej.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane signaling receptor activity uc291cej.1 uc291cej.2 
ENSMUST00000233603.2 Gm49898 ENSMUST00000233603.2 Gm49898 (from geneSymbol) ENSMUST00000233603.1 uc289hck.1 uc289hck.2 uc289hck.1 uc289hck.2 
ENSMUST00000233605.2 Vmn1r228 ENSMUST00000233605.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2A7) ENSMUST00000233605.1 Q8R2A7 Q8R2A7_MOUSE V1rd1 V1re3 Vmn1r228 uc289hnj.1 uc289hnj.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc289hnj.1 uc289hnj.2 
ENSMUST00000233645.2 Qki ENSMUST00000233645.2 quaking, KH domain containing RNA binding, transcript variant 1 (from RefSeq NM_001159517.2) ENSMUST00000233645.1 NM_001159517 O88972 Q61110 Q78ZE4 Q78ZE5 Q8K4X9 Q8K4Y0 Q9CW34 Q9QUH4 Q9QYS9 Q9R2A8 Q9Z246 QKI_MOUSE Qk Qk1 Qki uc008akb.1 uc008akb.2 uc008akb.3 uc008akb.4 RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (PubMed:10535969, PubMed:11297509, PubMed:11917126, PubMed:12467586, PubMed:15568022, PubMed:31868295, PubMed:36088389). Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development (PubMed:10535969, PubMed:11297509, PubMed:11917126, PubMed:12467586, PubMed:15568022, PubMed:31868295). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (PubMed:16041388). Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)- methylguanine (m7G) (By similarity). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons (PubMed:37272356). CircRNAs are produced by back-splicing circularization of pre-mRNAs (PubMed:37272356). Plays a central role in myelinization via 3 distinct mechanisms (PubMed:10864952, PubMed:12467586, PubMed:11917126, PubMed:15568022, PubMed:20956316, PubMed:21253564). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation (PubMed:10864952, PubMed:15568022, PubMed:28188285). Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA (PubMed:12467586). Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation (PubMed:11917126, PubMed:20956316, PubMed:21253564). Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (PubMed:33378678, PubMed:33045062). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (PubMed:36088389). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts (PubMed:33397958, PubMed:36627242). Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1 (PubMed:31868295). Also required for visceral endoderm function and blood vessel development (PubMed:11892011, PubMed:16470614). May also play a role in smooth muscle development (PubMed:14706070). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (PubMed:33942715, PubMed:34021134). [Isoform QKI5]: Nuclear isoform that acts as an indirect regulator of mRNA splicing (PubMed:11917126, PubMed:29021242). Regulates mRNA splicing of MAG pre-mRNA by inhibiting translation of HNRNPA1 mRNA, thereby preventing MAG exon 12 alternative splicing (PubMed:11917126, PubMed:21253564). Involved in oligodendrocyte differentiation by promoting stabilization of SIRT2 mRNA (PubMed:28188285). Acts as a negative regulator of the interferon response by binding to MAVS mRNA, downregulating its expression (By similarity). Also inhibits the interferon response by binding to fibrinectin FN1 pre-mRNA, repressing EDA exon inclusion in FN1 (By similarity). Delays macrophage differentiation by binding to CSF1R mRNA, promoting its degradation (By similarity). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2, promoting SREBF2/SREBP2-dependent cholesterol biosynthesis (PubMed:33942715, PubMed:34021134). SREBF2/SREBP2- dependent cholesterol biosynthesis participates to myelinization and is required for eye lens transparency (PubMed:33942715, PubMed:34021134). [Isoform QKI6]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)- methylguanine (m7G) (By similarity). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation (By similarity). Acts as a translational repressor for HNRNPA1 and GLI1 (PubMed:10535969, PubMed:16198329, PubMed:20956316, PubMed:29021242). Translation inhibition of HNRNPA1 during oligodendrocyte differentiation prevents inclusion of exon 12 in MAG pre-mRNA splicing (PubMed:20956316). Involved in astrocyte differentiation by regulating translation of target mRNAs (PubMed:33750804). [Isoform QKI7]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)- methylguanine (m7G) (By similarity). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation (By similarity). Acts as a negative regulator of angiogenesis by binding to mRNAs encoding CDH5, NLGN1 and TNFAIP6, promoting their degradation (PubMed:32732889). Can also induce apoptosis in the cytoplasm (PubMed:11297509). Heterodimerization with other isoforms results in nuclear translocation of isoform QKI7 and suppression of apoptosis (PubMed:11297509). Also binds some microRNAs: promotes stabilitation of miR-122 by mediating recruitment of poly(A) RNA polymerase TENT2, leading to 3' adenylation and stabilization of miR-122 (By similarity). Homodimer; does not require RNA to homodimerize (PubMed:10506177, PubMed:11297509, PubMed:9671495, PubMed:22982292). Able to heterodimerize with BICC1 (PubMed:9315629). [Isoform QKI6]: Interacts with G3BP1; directing N(7)- methylguanine (m7G)-containing mRNAs to stress granules to suppress mRNA translation. [Isoform QKI7]: Interacts with G3BP1; directing N(7)- methylguanine (m7G)-containing mRNAs to stress granules to suppress mRNA translation (By similarity). Interacts with TENT2; promoting stabilization of miR-122 (By similarity). Cytoplasm cleus [Isoform QKI5]: Nucleus Cytoplasm Note=Localizes predominantly in the nucleus and at lower levels in cytoplasm (PubMed:10506177, PubMed:29021242). It shuttles between the cytoplasm and the nucleus (PubMed:10506177). [Isoform QKI6]: Cytoplasm, cytosol cleus Note=Localizes predominantly in the cytoplasm and at lower levels in nucleus. [Isoform QKI7]: Cytoplasm, cytosol Cytoplasm, Stress granule Nucleus Note=Localizes predominantly in the cytoplasm and at much lower levels in nucleus (PubMed:11297509, PubMed:29021242). Shuttles between the cytosol and stress granules in response to stress (By similarity). Event=Alternative splicing; Named isoforms=8; Name=QKI5; Synonyms=QKI-5 IsoId=Q9QYS9-1; Sequence=Displayed; Name=QKI7B; Synonyms=QKI-7B ; IsoId=Q9QYS9-2; Sequence=VSP_019195; Name=QKI7; Synonyms=QkI-7 IsoId=Q9QYS9-3; Sequence=VSP_019196; Name=QKI6; Synonyms=QKI-6 KI-5B; IsoId=Q9QYS9-4; Sequence=VSP_019197; Name=QKID; IsoId=Q9QYS9-5; Sequence=VSP_019192, VSP_019193; Name=6; IsoId=Q9QYS9-6; Sequence=VSP_019194, VSP_019195; Name=QKI5A; Synonyms=QKI-5A ; IsoId=Q9QYS9-7; Sequence=VSP_019199; Name=QKIG; Synonyms=QKI-G; IsoId=Q9QYS9-8; Sequence=VSP_019198; Highly expressed in myelin-forming cells. Expressed in oligodendrocytes and astrocytes in the central nervous system as well as Schwann cells in the peripheral nervous system. Also expressed in the yolk sac endoderm, adjacent to the mesodermal site of developing blood islands, where the differentiation of blood and endothelial cells first occurs (at protein level). Expressed in brain, lung, heart and testis. Expressed in neural progenitors of the ventricular zone (vz) during CNS development, but that expression is down-regulated during neuronal differentiation (PubMed:9778149). By contrast, neural progenitors located in specific subdomains of the vz maintain expression as they differentiate and migrate away into the emerging nervous system (PubMed:9778149). These have characteristics consistent with the acquisition of a glial rather than neuronal fate (at protein level) First detected in the neuroepithelium of the head folds at 7.5 dpc (PubMed:9778149). Expression is strongly present ventrally in the nascent brain and neural tube of 8.5 dpc and 9.5 dpc and in the heart of 8.5 dpc (PubMed:9778149). [Isoform QKI5]: Expressed in early embryos, while isoform QKI6 and isoform QKI7 are found in late development when myelination begins. [Isoform QKI7]: Expressed in late development when myelination begins. [Isoform QKI6]: Expressed in late development when myelination begins. The KH domain and the Qua2 region are involved in RNA binding. Methylated by PRMT1. Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA. The level of Tyr phosphorylation in the developing myelin is highest in the first postnatal week (P7). During the vigorous accumulation of MBP mRNA between P7 and P20, phosphorylation in the developing myelin drastically declines. By the end of the fourth postnatal week (P28), phosphorylation is reduced approximately 90%. Ubiquitinated by RNF6 in macrophages, leading to its degradation. Note=Defects in Qki are the cause of quakingviable (qkv). Qkv is a spontaneous mutation resulting in hypomyelinization of the central and peripheral nervous systems. Mutant mice develop normally until postnatal day 10 when they display rapid tremors or 'quaking' that is especially pronounced in hindlimbs and experience convulsive tonic- clonic seizures as they mature (PubMed:8589716). Mice with qkv specifically lack isoform 3 and isoform 4 in myelin-forming cells, while isoform 1 is lacking in oligodendrocytes of severely affected tracts (PubMed:12888522). Mice with qkv also lack the PRKN gene product, suggesting that the absence of PRKN may also affect the phenotype (PubMed:15014970). Embryonic lethality between 9.5 and 10.5 days post coitum (dpc) (PubMed:14706070). Embryos show a lack of large vitelline vessels in the yolk sacs, kinky neural tubes, pericardial effusion, open neural tubes and incomplete embryonic turning (PubMed:14706070). Conditional deletion in cardiomyocytes in the adult heart induces dilation of the ventricles and a rapid decline in cardiac function, associated with severe disruption of sarcomere organization (PubMed:36627242). Conditional deletion in neural stem cells leads to hypomyelination in the central nervous system due to impaired cholesterol biosynthesis (PubMed:33942715). Conditional deletion in microglia induces an inflammation phenotype, characterized by increased proinflammatory cytokine release and defects in processing phagocytosed cargo, leading to impaired remyelination (PubMed:33378678). Conditional deletion in astrocytes leads to impaired astrocyte maturation (PubMed:33750804). Belongs to the quaking family. vasculogenesis nucleic acid binding RNA binding mRNA binding nucleus cytoplasm mRNA processing regulation of translation multicellular organism development spermatid development axon ensheathment RNA splicing positive regulation of gene expression negative regulation of cardiac muscle cell apoptotic process positive regulation of neuron projection development SH3 domain binding cell differentiation myelination muscle cell differentiation long-chain fatty acid biosynthetic process synapse mRNA stabilization positive regulation of oligodendrocyte differentiation mRNA transport 3'-UTR-mediated mRNA destabilization uc008akb.1 uc008akb.2 uc008akb.3 uc008akb.4 
ENSMUST00000233670.2 Vmn1r230 ENSMUST00000233670.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2A2) ENSMUST00000233670.1 Q8R2A2 Q8R2A2_MOUSE V1re8 Vmn1r230 uc289hnp.1 uc289hnp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc289hnp.1 uc289hnp.2 
ENSMUST00000233672.2 Esp5 ENSMUST00000233672.2 predicted readthrough transcript, 44501 (from RefSeq NM_001287195.1) A8R0T9 A8R0T9_MOUSE ENSMUST00000233672.1 Esp5 Gm44501 NM_001287195 uc289lem.1 uc289lem.2 This locus represents naturally occurring readthrough transcription between the neighboring Esp6 (exocrine gland secreted peptide 6) and Esp5 (exocrine gland secreted peptide 5) genes on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the downstream gene product, but is shorter at its N-terminus. [provided by RefSeq, Dec 2013]. ##Evidence-Data-START## Transcript exon combination :: AB306983.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 433107, 102577427 ##RefSeq-Attributes-END## pheromone activity extracellular space uc289lem.1 uc289lem.2 
ENSMUST00000233690.2 Gm49924 ENSMUST00000233690.2 Gm49924 (from geneSymbol) ENSMUST00000233690.1 uc289mso.1 uc289mso.2 uc289mso.1 uc289mso.2 
ENSMUST00000233692.2 Lrrc73 ENSMUST00000233692.2 leucine rich repeat containing 73, transcript variant 4 (from RefSeq NM_001417728.1) B2RWC4 B2RWC4_MOUSE ENSMUST00000233692.1 Gm88 Lrrc73 NM_001417728 uc012auo.1 uc012auo.2 uc012auo.3 molecular_function cellular_component biological_process uc012auo.1 uc012auo.2 uc012auo.3 
ENSMUST00000233693.2 Gm49964 ENSMUST00000233693.2 Gm49964 (from geneSymbol) ENSMUST00000233693.1 uc289gzs.1 uc289gzs.2 uc289gzs.1 uc289gzs.2 
ENSMUST00000233708.2 Gm13274 ENSMUST00000233708.2 Gm13274 (from geneSymbol) AK144774 ENSMUST00000233708.1 uc290nrq.1 uc290nrq.2 uc290nrq.1 uc290nrq.2 
ENSMUST00000233710.2 Gm49804 ENSMUST00000233710.2 Reaction=diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.; EC=3.6.1.52; Evidence=; (from UniProt A0A3B2W864) A0A3B2W864 A0A3B2W864_MOUSE AK145441 ENSMUST00000233710.1 Gm49804 uc289itq.1 uc289itq.2 Reaction=diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.; EC=3.6.1.52; Evidence=; Belongs to the Nudix hydrolase family. DIPP subfamily. Belongs to the eukaryotic ribosomal protein eS10 family. hydrolase activity uc289itq.1 uc289itq.2 
ENSMUST00000233721.2 Gm49958 ENSMUST00000233721.2 Gm49958 (from geneSymbol) ENSMUST00000233721.1 uc289haf.1 uc289haf.2 uc289haf.1 uc289haf.2 
ENSMUST00000233737.2 Gm36684 ENSMUST00000233737.2 Gm36684 (from geneSymbol) DQ716826 ENSMUST00000233737.1 uc289hcn.1 uc289hcn.2 uc289hcn.1 uc289hcn.2 
ENSMUST00000233755.2 Map3k4 ENSMUST00000233755.2 mitogen-activated protein kinase kinase kinase 4, transcript variant 2 (from RefSeq NM_001357722.1) ENSMUST00000233755.1 M3K4_MOUSE Mekk4 NM_001357722 O08648 O08649 O70124 Q6PDG6 uc008ako.1 uc008ako.2 uc008ako.3 Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.25; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; N-terminal autoinhibitory domain interacts with the C-terminal kinase domain, inhibiting kinase activity, and preventing interaction with its substrate, MAP2K6. The GADD45 proteins activate the kinase by binding to the N-terminal domain. Activated by phosphorylation on Thr-1494 (By similarity). Monomer and homodimer. Homodimerization enhances kinase activity. Interacts with CDC42 (PubMed:9079650). Interacts with TRAF4; this promotes homodimerization (PubMed:16157600). Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with AXIN1 and DIXDC1; interaction with DIXDC1 prevents interaction with AXIN1 (PubMed:15262978). Interacts with GADD45 and MAP2K6 (By similarity). Interacts with ZFP36; this interaction enhances the association with SH3KBP1/CIN85. Interacts with SH3KBP1; this interaction enhances the association with ZFP36 (By similarity). Cytoplasm, perinuclear region Note=Localized in perinuclear vesicular- like structures, probably Golgi-associated vesicles. Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=O08648-1; Sequence=Displayed; Name=B; IsoId=O08648-2; Sequence=VSP_004885; Widely expressed. High expression was found in skeletal muscle, kidney, testis followed by heart brain and lung. Low expression was found in spleen. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. MAPK cascade nucleotide binding activation of MAPKK activity placenta development protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity protein binding ATP binding cytoplasm protein phosphorylation response to UV-C regulation of gene expression kinase activity phosphorylation transferase activity male germ-line sex determination signal transduction by protein phosphorylation activation of protein kinase activity positive regulation of telomere maintenance via telomerase intracellular signal transduction positive regulation of JUN kinase activity metal ion binding determination of dorsal identity perinuclear region of cytoplasm positive regulation of telomerase activity chorionic trophoblast cell differentiation positive regulation of p38MAPK cascade positive regulation of telomere capping uc008ako.1 uc008ako.2 uc008ako.3 
ENSMUST00000233765.2 Fut4-ps1 ENSMUST00000233765.2 fucosyltransferase 4, pseudogene 1 (from RefSeq NR_033644.1) ENSMUST00000233765.1 NR_033644 uc012avx.1 uc012avx.2 uc012avx.1 uc012avx.2 
ENSMUST00000233771.2 Vmn2r60 ENSMUST00000233771.2 vomeronasal 2, receptor 60 (from RefSeq NM_001105057.1) A0A3B2WBC8 A0A3B2WBC8_MOUSE ENSMUST00000233771.1 NM_001105057 Vmn2r60 uc012fiw.1 uc012fiw.2 uc012fiw.3 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc012fiw.1 uc012fiw.2 uc012fiw.3 
ENSMUST00000233774.2 Cramp1 ENSMUST00000233774.2 cramped chromatin regulator 1, transcript variant 2 (from RefSeq NM_001403565.1) CRML_MOUSE Cramp1 Cramp1l E9QNA8 ENSMUST00000233774.1 Hn1l Kiaa1426 NM_001403565 Q6PG95 Q6ZPR3 Tce4 uc008azl.1 uc008azl.2 uc008azl.3 Nucleus Belongs to the cramped family. Sequence=AK147411; Type=Frameshift; Evidence=; DNA binding chromatin binding nucleus biological_process uc008azl.1 uc008azl.2 uc008azl.3 
ENSMUST00000233779.2 Gm20098 ENSMUST00000233779.2 predicted gene, 20098 (from RefSeq NR_045095.1) ENSMUST00000233779.1 NR_045095 uc029tit.1 uc029tit.2 uc029tit.1 uc029tit.2 
ENSMUST00000233785.2 Gm49938 ENSMUST00000233785.2 Gm49938 (from geneSymbol) ENSMUST00000233785.1 uc289mlt.1 uc289mlt.2 uc289mlt.1 uc289mlt.2 
ENSMUST00000233788.2 Gm49928 ENSMUST00000233788.2 Gm49928 (from geneSymbol) ENSMUST00000233788.1 uc289gmi.1 uc289gmi.2 uc289gmi.1 uc289gmi.2 
ENSMUST00000233801.3 4930542M03Rik ENSMUST00000233801.3 RIKEN cDNA 4930542M03 gene (from RefSeq NR_152136.1) ENSMUST00000233801.1 ENSMUST00000233801.2 NR_152136 uc289ljs.1 uc289ljs.2 uc289ljs.3 uc289ljs.1 uc289ljs.2 uc289ljs.3 
ENSMUST00000233834.3 Gm49953 ENSMUST00000233834.3 Gm49953 (from geneSymbol) ENSMUST00000233834.1 ENSMUST00000233834.2 uc289glv.1 uc289glv.2 uc289glv.3 uc289glv.1 uc289glv.2 uc289glv.3 
ENSMUST00000233877.3 Gm19585 ENSMUST00000233877.3 Gm19585 (from geneSymbol) ENSMUST00000233877.1 ENSMUST00000233877.2 uc289lwl.1 uc289lwl.2 uc289lwl.3 uc289lwl.1 uc289lwl.2 uc289lwl.3 
ENSMUST00000233892.2 Vmn2r53 ENSMUST00000233892.2 vomeronasal 2, receptor 53 (from RefSeq NM_001104644.2) A0A3B2W4A7 A0A3B2W4A7_MOUSE ENSMUST00000233892.1 NM_001104644 Vmn2r53 uc291loz.1 uc291loz.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane signaling receptor activity uc291loz.1 uc291loz.2 
ENSMUST00000233896.2 ENSMUSG00000121756 ENSMUST00000233896.2 ENSMUSG00000121756 (from geneSymbol) ENSMUST00000233896.1 uc289jft.1 uc289jft.2 uc289jft.1 uc289jft.2 
ENSMUST00000233910.3 Gm49894 ENSMUST00000233910.3 Gm49894 (from geneSymbol) ENSMUST00000233910.1 ENSMUST00000233910.2 uc289mnn.1 uc289mnn.2 uc289mnn.3 uc289mnn.1 uc289mnn.2 uc289mnn.3 
ENSMUST00000233923.2 Armc12 ENSMUST00000233923.2 armadillo repeat containing 12 (from RefSeq NM_026290.3) ARM12_MOUSE ENSMUST00000233923.1 NM_026290 Q80X86 Q9D564 Q9DAN7 uc008brd.1 uc008brd.2 uc008brd.3 uc008brd.4 Essential for male fertility and sperm mitochondrial sheath formation (PubMed:33536340). Required for proper mitochondrial elongation and coiling along the flagellum during the formation of the mitochondrial sheath (PubMed:33536340). Facilitates the growth and aggressiveness of neuroblastoma cells (By similarity). Increases the EZH2 activity and H3K27me3 levels in a RBBP4-dependent manner, and facilitates the enrichment of polycomb repressive complex 2 and H3K27me3 on gene promoters, resulting in transcriptional repression of tumor suppressors affecting the proliferation, invasion, and metastasis of tumor cells (By similarity). Interacts with TBC1D15, TBC1D21, GK2 and IMMT (PubMed:33536340). Interacts with VDAC2 and VDAC3 in a TBC1D21- dependent manner (PubMed:33536340). Interacts (via ARM domains) with RBBP4 (By similarity). Nucleus Mitochondrion outer membrane ; Peripheral membrane protein Testis-specific. Expression begins around postnatal day 20, which roughly corresponds to the haploid, round spermatid stage of spermatogenesis. Male mice are infertile due to reduced sperm motility and abnormal sperm morphology. molecular_function biological_process uc008brd.1 uc008brd.2 uc008brd.3 uc008brd.4 
ENSMUST00000233925.2 Gm49864 ENSMUST00000233925.2 Gm49864 (from geneSymbol) ENSMUST00000233925.1 uc289jbv.1 uc289jbv.2 uc289jbv.1 uc289jbv.2 
ENSMUST00000233927.2 Mir100hg ENSMUST00000233927.2 Mir100hg (from geneSymbol) AK014147 ENSMUST00000233927.1 uc292ggc.1 uc292ggc.2 uc292ggc.1 uc292ggc.2 
ENSMUST00000233931.2 Setd4 ENSMUST00000233931.2 SET domain containing 4, transcript variant 14 (from RefSeq NR_184424.1) ENSMUST00000233931.1 G3X9W6 NR_184424 ORF21 P58467 SETD4_MOUSE Setd4 uc007zzq.1 uc007zzq.2 uc007zzq.3 uc007zzq.4 Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response (PubMed:31376731, PubMed:31794893, PubMed:33506343). Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro-inflammatory cytokines IL6 and TNF-alpha (PubMed:31376731). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (By similarity). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (PubMed:33506343). Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364; Evidence=; Reaction=N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60268, Rhea:RHEA-COMP:15540, Rhea:RHEA- COMP:15543, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; Reaction=L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60344, Rhea:RHEA-COMP:15554, Rhea:RHEA-COMP:15555, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence=; Reaction=N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60348, Rhea:RHEA-COMP:15555, Rhea:RHEA- COMP:15556, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; Evidence=; Reaction=N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L- methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61992, Rhea:RHEA- COMP:15556, Rhea:RHEA-COMP:15998, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961, ChEBI:CHEBI:61976; Evidence=; Cytoplasm, cytosol Nucleus No visible phenotype in normal physiological conditions (PubMed:33506343). Increased proliferation of bone marrow mesenchymal stem cells (BMSCs), impaired BMSCs migration and differentiation potentials of lineages of cardiacmyocyte and smooth muscle cell (PubMed:33506343). Conditional deletion in adult mice improves the survival from radiation-induced hematopoietic failure and thymic lymphoma (PubMed:31794893, PubMed:32259569). Extends survival from radiation-induced thymic lymphoma is likely due to slower tumor enlargement in the thymus (PubMed:31794893). Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family. nucleus cytoplasm cytosol methyltransferase activity protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine monomethylation methylation uc007zzq.1 uc007zzq.2 uc007zzq.3 uc007zzq.4 
ENSMUST00000233959.2 Vmn1r226 ENSMUST00000233959.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2A8) ENSMUST00000233959.1 Q8R2A8 Q8R2A8_MOUSE V1re2 Vmn1r225 Vmn1r226 uc289hna.1 uc289hna.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc289hna.1 uc289hna.2 
ENSMUST00000233974.2 Klc4 ENSMUST00000233974.2 kinesin light chain 4, transcript variant 2 (from RefSeq NM_001357130.1) ENSMUST00000233974.1 KLC4_MOUSE Knsl8 NM_001357130 Q3TCC5 Q9DBS5 uc008ctk.1 uc008ctk.2 uc008ctk.3 Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). Oligomeric complex composed of two heavy chains and two light chains. Cytoplasm, cytoskeleton Belongs to the kinesin light chain family. molecular_function microtubule motor activity cellular_component cytoplasm cytoskeleton kinesin complex microtubule biological_process uc008ctk.1 uc008ctk.2 uc008ctk.3 
ENSMUST00000233980.2 Vmn1r224 ENSMUST00000233980.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9PWK2) E9PWK2 E9PWK2_MOUSE ENSMUST00000233980.1 Vmn1r224 uc289hme.1 uc289hme.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc289hme.1 uc289hme.2 
ENSMUST00000233982.2 Vmn1r225 ENSMUST00000233982.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2A5) ENSMUST00000233982.1 Q8R2A5 Q8R2A5_MOUSE V1re5 Vmn1r225 uc289hmp.1 uc289hmp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc289hmp.1 uc289hmp.2 
ENSMUST00000233984.2 Mapk13 ENSMUST00000233984.2 mitogen-activated protein kinase 13 (from RefSeq NM_011950.2) ENSMUST00000233984.1 MK13_MOUSE NM_011950 Q99M57 Q9Z1B7 Serk4 uc008bro.1 uc008bro.2 uc008bro.3 uc008bro.4 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up- regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down- regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Activated by phosphorylation on threonine and tyrosine by dual specificity kinases, MAP2K3/MKK3, MAP2K6/MKK6, MAP2K4/MKK4 and MAP2K7/MKK7. Activation by ultraviolet radiation, hyperosmotic shock, anisomycin or by TNF-alpha is mediated by MAP2K3/MKK3. Inhibited by dual specificity phosphatase DUSP1. Interacts with MAPK8IP2. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1 (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. MAPK cascade nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity ATP binding nucleus nucleoplasm cytoplasm protein phosphorylation response to osmotic stress cell cycle regulation of gene expression kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation positive regulation of interleukin-6 production cellular response to UV intracellular signal transduction stress-activated MAPK cascade cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to sorbitol cellular response to anisomycin cellular response to sodium arsenite uc008bro.1 uc008bro.2 uc008bro.3 uc008bro.4 
ENSMUST00000233985.3 Gm56917 ENSMUST00000233985.3 Gm56917 (from geneSymbol) ENSMUST00000233985.1 ENSMUST00000233985.2 uc289mld.1 uc289mld.2 uc289mld.3 uc289mld.1 uc289mld.2 uc289mld.3 
ENSMUST00000233996.3 Gm50019 ENSMUST00000233996.3 Gm50019 (from geneSymbol) ENSMUST00000233996.1 ENSMUST00000233996.2 uc289jmx.1 uc289jmx.2 uc289jmx.3 uc289jmx.1 uc289jmx.2 uc289jmx.3 
ENSMUST00000234013.2 Gm49974 ENSMUST00000234013.2 Gm49974 (from geneSymbol) ENSMUST00000234013.1 uc289paz.1 uc289paz.2 uc289paz.1 uc289paz.2 
ENSMUST00000234018.2 Gm53018 ENSMUST00000234018.2 Gm53018 (from geneSymbol) ENSMUST00000234018.1 uc289odq.1 uc289odq.2 uc289odq.1 uc289odq.2 
ENSMUST00000234040.2 Gm26885 ENSMUST00000234040.2 predicted gene, 26885, transcript variant 1 (from RefSeq NR_168683.1) ENSMUST00000234040.1 NR_168683 uc289jji.1 uc289jji.2 uc289jji.1 uc289jji.2 
ENSMUST00000234045.2 Gm41669 ENSMUST00000234045.2 Gm41669 (from geneSymbol) AK082205 ENSMUST00000234045.1 uc289odo.1 uc289odo.2 uc289odo.1 uc289odo.2 
ENSMUST00000234056.2 Gm50064 ENSMUST00000234056.2 Gm50064 (from geneSymbol) AK042437 ENSMUST00000234056.1 uc289nro.1 uc289nro.2 uc289nro.1 uc289nro.2 
ENSMUST00000234068.2 4933435E02Rik ENSMUST00000234068.2 4933435E02Rik (from geneSymbol) AK017066 ENSMUST00000234068.1 uc289ons.1 uc289ons.2 uc289ons.1 uc289ons.2 
ENSMUST00000234076.2 4933433H22Rik ENSMUST00000234076.2 RIKEN cDNA 4933433H22 gene (from RefSeq NR_045458.1) ENSMUST00000234076.1 NR_045458 uc029tkx.1 uc029tkx.2 uc029tkx.1 uc029tkx.2 
ENSMUST00000234078.3 Gm50000 ENSMUST00000234078.3 Gm50000 (from geneSymbol) ENSMUST00000234078.1 ENSMUST00000234078.2 uc289jpl.1 uc289jpl.2 uc289jpl.3 uc289jpl.1 uc289jpl.2 uc289jpl.3 
ENSMUST00000234081.2 Adcyap1 ENSMUST00000234081.2 adenylate cyclase activating polypeptide 1, transcript variant 10 (from RefSeq NM_001412216.1) Adcyap1 ENSMUST00000234081.1 NM_001412216 Q3UYH8 Q3UYH8_MOUSE uc008dwi.1 uc008dwi.2 uc008dwi.3 uc008dwi.4 Interacts with ADCYAP1R1 (via N-terminal extracellular domain). Secreted Belongs to the glucagon family. ovarian follicle development behavioral fear response histamine secretion regulation of protein phosphorylation negative regulation of acute inflammatory response to antigenic stimulus negative regulation of acute inflammatory response to non-antigenic stimulus receptor binding hormone activity neuropeptide hormone activity extracellular region extracellular space G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation negative regulation of muscle cell apoptotic process positive regulation of neuron projection development pituitary adenylate cyclase activating polypeptide activity sensory perception of pain cAMP-mediated signaling pituitary gland development insulin secretion neuron projection development pituitary adenylate cyclase-activating polypeptide receptor binding positive regulation of interleukin-6 production regulation of protein localization negative regulation of GTPase activity response to starvation terminal bouton negative regulation of potassium ion transport positive regulation of GTPase activity positive regulation of cAMP-mediated signaling response to ethanol positive regulation of protein kinase activity positive regulation of transcription from RNA polymerase II promoter ATP metabolic process peptide hormone receptor binding positive regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential positive regulation of growth hormone secretion negative regulation of glial cell proliferation positive regulation of ERK1 and ERK2 cascade regulation of oligodendrocyte progenitor proliferation cellular response to glucocorticoid stimulus positive regulation of chemokine (C-C motif) ligand 5 production positive regulation of somatostatin secretion uc008dwi.1 uc008dwi.2 uc008dwi.3 uc008dwi.4 
ENSMUST00000234087.2 Gm54542 ENSMUST00000234087.2 Gm54542 (from geneSymbol) AK035992 ENSMUST00000234087.1 uc289nhj.1 uc289nhj.2 uc289nhj.1 uc289nhj.2 
ENSMUST00000234097.2 Gm50021 ENSMUST00000234097.2 Gm50021 (from geneSymbol) AK138659 ENSMUST00000234097.1 uc289mwz.1 uc289mwz.2 uc289mwz.1 uc289mwz.2 
ENSMUST00000234107.2 Rnf138 ENSMUST00000234107.2 E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. (from UniProt Q9CQE0) AK010486 ENSMUST00000234107.1 Q9CQE0 Q9WTR9 Q9WTS0 RN138_MOUSE Rnf138 Trif uc289ogz.1 uc289ogz.2 E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with NLK. Interacts with XRCC5/Ku80. Interacts with RBBP8/CtIP. Chromosome Note=Recruited at DNA damage sites. Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQE0-1; Sequence=Displayed; Name=2; IsoId=Q9CQE0-2; Sequence=VSP_021733; The zinc finger domains (C2H2-type and C2HC-type zinc fingers) bind DNA and mediate recruitment to double-strand break sites. They show strong preference for DNA with 5'- or 3'-single-stranded overhangs, while they do not bind blunt-ended double-stranded DNA or poly(ADP-ribose) (PAR) polymers. Auto-ubiquitinated. double-strand break repair via homologous recombination DNA binding single-stranded DNA binding chromosome DNA repair cellular response to DNA damage stimulus DNA double-strand break processing involved in repair via single-strand annealing Wnt signaling pathway protein ubiquitination transferase activity protein kinase binding site of double-strand break metal ion binding ubiquitin protein ligase activity cellular response to leukemia inhibitory factor uc289ogz.1 uc289ogz.2 
ENSMUST00000234126.2 Gm9993 ENSMUST00000234126.2 predicted gene 9993 (from RefSeq NR_188731.1) ENSMUST00000234126.1 NR_188731 uc289nuv.1 uc289nuv.2 uc289nuv.1 uc289nuv.2 
ENSMUST00000234127.2 Gm33948 ENSMUST00000234127.2 RIKEN cDNA 4930474G06 gene (from RefSeq NR_045398.1) ENSMUST00000234127.1 NR_045398 uc289oll.1 uc289oll.2 uc289oll.1 uc289oll.2 
ENSMUST00000234128.3 Gm31086 ENSMUST00000234128.3 Gm31086 (from geneSymbol) ENSMUST00000234128.1 ENSMUST00000234128.2 uc289ogg.1 uc289ogg.2 uc289ogg.3 uc289ogg.1 uc289ogg.2 uc289ogg.3 
ENSMUST00000234130.2 Gm50022 ENSMUST00000234130.2 Gm50022 (from geneSymbol) ENSMUST00000234130.1 uc289idz.1 uc289idz.2 uc289idz.1 uc289idz.2 
ENSMUST00000234135.2 Gm50046 ENSMUST00000234135.2 Gm50046 (from geneSymbol) ENSMUST00000234135.1 uc289jrs.1 uc289jrs.2 uc289jrs.1 uc289jrs.2 
ENSMUST00000234144.2 Phf8l ENSMUST00000234144.2 PHD finger protein 8 like (from RefSeq NR_160433.1) ENSMUST00000234144.1 NR_160433 uc289jtn.1 uc289jtn.2 uc289jtn.1 uc289jtn.2 
ENSMUST00000234156.2 Gm50013 ENSMUST00000234156.2 Gm50013 (from geneSymbol) ENSMUST00000234156.1 uc289ipt.1 uc289ipt.2 uc289ipt.1 uc289ipt.2 
ENSMUST00000234167.2 4930415O11Rik ENSMUST00000234167.2 4930415O11Rik (from geneSymbol) AK015154 ENSMUST00000234167.1 uc289nud.1 uc289nud.2 uc289nud.1 uc289nud.2 
ENSMUST00000234174.2 Gm50037 ENSMUST00000234174.2 Gm50037 (from geneSymbol) ENSMUST00000234174.1 uc289jyy.1 uc289jyy.2 uc289jyy.1 uc289jyy.2 
ENSMUST00000234209.3 Gm50063 ENSMUST00000234209.3 Gm50063 (from geneSymbol) ENSMUST00000234209.1 ENSMUST00000234209.2 uc289oca.1 uc289oca.2 uc289oca.3 uc289oca.1 uc289oca.2 uc289oca.3 
ENSMUST00000234213.2 Gm49970 ENSMUST00000234213.2 Gm49970 (from geneSymbol) ENSMUST00000234213.1 uc289ocu.1 uc289ocu.2 uc289ocu.1 uc289ocu.2 
ENSMUST00000234217.2 Gm50087 ENSMUST00000234217.2 Gm50087 (from geneSymbol) AK139951 ENSMUST00000234217.1 uc289nbu.1 uc289nbu.2 uc289nbu.1 uc289nbu.2 
ENSMUST00000234218.2 8430422H06Rik ENSMUST00000234218.2 RIKEN cDNA 8430422H06 gene (from RefSeq NR_045373.1) ENSMUST00000234218.1 NR_045373 uc029tlu.1 uc029tlu.2 uc029tlu.3 uc029tlu.1 uc029tlu.2 uc029tlu.3 
ENSMUST00000234225.3 Gm29992 ENSMUST00000234225.3 Gm29992 (from geneSymbol) ENSMUST00000234225.1 ENSMUST00000234225.2 uc289odz.1 uc289odz.2 uc289odz.3 uc289odz.1 uc289odz.2 uc289odz.3 
ENSMUST00000234240.2 Gm50010 ENSMUST00000234240.2 Gm50010 (from geneSymbol) AK049147 ENSMUST00000234240.1 uc289noa.1 uc289noa.2 uc289noa.1 uc289noa.2 
ENSMUST00000234241.2 Zfp438 ENSMUST00000234241.2 zinc finger protein 438, transcript variant 2 (from RefSeq NM_001360447.1) ENSMUST00000234241.1 NM_001360447 Q8BFX2 Q8BFX2_MOUSE Zfp438 uc289nrm.1 uc289nrm.2 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol negative regulation of transcription, DNA-templated uc289nrm.1 uc289nrm.2 
ENSMUST00000234242.2 Gm49971 ENSMUST00000234242.2 Gm49971 (from geneSymbol) ENSMUST00000234242.1 uc289pat.1 uc289pat.2 uc289pat.1 uc289pat.2 
ENSMUST00000234252.2 Gm50056 ENSMUST00000234252.2 Gm50056 (from geneSymbol) ENSMUST00000234252.1 uc289nla.1 uc289nla.2 uc289nla.1 uc289nla.2 
ENSMUST00000234266.2 Elp2 ENSMUST00000234266.2 elongator acetyltransferase complex subunit 2, transcript variant 1 (from RefSeq NM_021448.2) ELP2_MOUSE ENSMUST00000234266.1 NM_021448 Q3TIH5 Q3TIT0 Q8CBW6 Q91WG4 Q9ESY7 Statip1 uc008egx.1 uc008egx.2 uc008egx.3 Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator comple catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Component of the elongator complex which consists of ELP1, ELP2, ELP3, ELP4, ELP5 and ELP6. Interacts with STAT3 and JAKs (PubMed:10954736). Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91WG4-1; Sequence=Displayed; Name=2; IsoId=Q91WG4-2; Sequence=VSP_016534; Folds into a two seven-bladed beta-propeller structure which is required for elongator complex assembly. Belongs to the WD repeat ELP2 family. The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification. proteasome complex tRNA wobble uridine modification protein binding nucleus cytoplasm cytosol transcription elongation from RNA polymerase II promoter transcription elongation factor complex positive regulation of endopeptidase activity protein kinase binding Elongator holoenzyme complex proteasome assembly regulation of JAK-STAT cascade endopeptidase activator activity RNA polymerase II core binding uc008egx.1 uc008egx.2 uc008egx.3 
ENSMUST00000234275.2 Gm50009 ENSMUST00000234275.2 Gm50009 (from geneSymbol) AK046075 ENSMUST00000234275.1 uc289nnz.1 uc289nnz.2 uc289nnz.1 uc289nnz.2 
ENSMUST00000234279.2 A430019L02Rik ENSMUST00000234279.2 A430019L02Rik (from geneSymbol) ENSMUST00000234279.1 uc289pas.1 uc289pas.2 uc289pas.1 uc289pas.2 
ENSMUST00000234288.2 1110020A21Rik ENSMUST00000234288.2 RIKEN cDNA 1110020A21 gene, transcript variant 1 (from RefSeq NR_027929.1) ENSMUST00000234288.1 NR_027929 uc008dtd.1 uc008dtd.2 uc008dtd.3 uc008dtd.4 uc008dtd.1 uc008dtd.2 uc008dtd.3 uc008dtd.4 
ENSMUST00000234295.4 Gm20939 ENSMUST00000234295.4 Gm20939 (from geneSymbol) BC070434 ENSMUST00000234295.1 ENSMUST00000234295.2 ENSMUST00000234295.3 uc289nof.1 uc289nof.2 uc289nof.3 uc289nof.4 uc289nof.1 uc289nof.2 uc289nof.3 uc289nof.4 
ENSMUST00000234304.2 Eci1 ENSMUST00000234304.2 enoyl-Coenzyme A delta isomerase 1 (from RefSeq NM_010023.4) Dci ECI1_MOUSE ENSMUST00000234304.1 Eci1 NM_010023 P42125 Q8QZV3 uc008avv.1 uc008avv.2 uc008avv.3 uc008avv.4 Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl- CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length. Reaction=a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA; Xref=Rhea:RHEA:45900, ChEBI:CHEBI:85097, ChEBI:CHEBI:85489; EC=5.3.3.8; Evidence=; Reaction=a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA; Xref=Rhea:RHEA:45228, ChEBI:CHEBI:58521, ChEBI:CHEBI:85097; EC=5.3.3.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45229; Evidence=; Reaction=(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA; Xref=Rhea:RHEA:46044, ChEBI:CHEBI:62242, ChEBI:CHEBI:85640; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46045; Evidence=; Reaction=(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA; Xref=Rhea:RHEA:29847, ChEBI:CHEBI:61405, ChEBI:CHEBI:61968; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29849; Evidence=; Reaction=(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA; Xref=Rhea:RHEA:23716, ChEBI:CHEBI:57330, ChEBI:CHEBI:58543; EC=5.3.3.8; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23717; Evidence=; Reaction=(3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA; Xref=Rhea:RHEA:45748, ChEBI:CHEBI:62077, ChEBI:CHEBI:85415; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45749; Evidence=; Reaction=(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA; Xref=Rhea:RHEA:77195, ChEBI:CHEBI:61406, ChEBI:CHEBI:195601; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77196; Evidence=; Lipid metabolism; fatty acid beta-oxidation. Homotrimer. Mitochondrion matrix Belongs to the enoyl-CoA hydratase/isomerase family. catalytic activity dodecenoyl-CoA delta-isomerase activity enoyl-CoA hydratase activity mitochondrion mitochondrial inner membrane mitochondrial matrix lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation isomerase activity identical protein binding uc008avv.1 uc008avv.2 uc008avv.3 uc008avv.4 
ENSMUST00000234305.2 Tmem217b ENSMUST00000234305.2 transmembrane 217B (from RefSeq NM_001424294.1) A0A3Q4EHH0 A0A3Q4EHH0_MOUSE ENSMUST00000234305.1 Gm17657 NM_001424294 Tmem217b uc289jkp.1 uc289jkp.2 membrane integral component of membrane uc289jkp.1 uc289jkp.2 
ENSMUST00000234316.2 Rnf125 ENSMUST00000234316.2 ring finger protein 125, transcript variant 2 (from RefSeq NM_001364973.1) ENSMUST00000234316.1 NM_001364973 Q0VG32 Q52KL4 Q8C7F2 Q9D9R0 RN125_MOUSE uc008efa.1 uc008efa.2 uc008efa.3 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation. Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=; Protein modification; protein ubiquitination. Interacts with UBE2D1. Interacts with VCP/p97; leading to recruit RNF125 to RIGI and promote ubiquitination of RIGI. Golgi apparatus membrane ; Lipid-anchor Note=Shows a reticular staining pattern within the cell and is probably expressed at other intracellular membranes in addition to the Golgi membrane. Not detected at the plasma membrane. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D9R0-1; Sequence=Displayed; Name=2; IsoId=Q9D9R0-2; Sequence=VSP_015216; The C2HC RNF-type zinc finger and the linker region stabilize the RING-type zinc finger, leading to promote binding of the RING-type zinc finger to the ubiquitin-conjugating enzyme E2 (donor ubiquitin). Autoubiquitinated, leading to its subsequent proteasomal degradation. Sequence=BAB24656.1; Type=Frameshift; Evidence=; Golgi membrane protein polyubiquitination p53 binding adaptive immune response immune system process ubiquitin-protein transferase activity Golgi apparatus cytosol ubiquitin-dependent protein catabolic process zinc ion binding membrane protein ubiquitination transferase activity ubiquitin conjugating enzyme binding negative regulation of type I interferon production VCP-NPL4-UFD1 AAA ATPase complex negative regulation of RIG-I signaling pathway intracellular membrane-bounded organelle metal ion binding ubiquitin protein ligase activity cellular response to leukemia inhibitory factor uc008efa.1 uc008efa.2 uc008efa.3 
ENSMUST00000234317.2 Gm50071 ENSMUST00000234317.2 Gm50071 (from geneSymbol) ENSMUST00000234317.1 uc289hwr.1 uc289hwr.2 uc289hwr.1 uc289hwr.2 
ENSMUST00000234329.2 Gm50070 ENSMUST00000234329.2 Gm50070 (from geneSymbol) ENSMUST00000234329.1 uc289hwy.1 uc289hwy.2 uc289hwy.1 uc289hwy.2 
ENSMUST00000234345.2 Gm50068 ENSMUST00000234345.2 Gm50068 (from geneSymbol) ENSMUST00000234345.1 uc289jgh.1 uc289jgh.2 uc289jgh.1 uc289jgh.2 
ENSMUST00000234364.3 1810073O08Rik ENSMUST00000234364.3 RIKEN cDNA 1810073O08 gene (from RefSeq NR_166916.2) ENSMUST00000234364.1 ENSMUST00000234364.2 NR_166916 uc289nem.1 uc289nem.2 uc289nem.3 uc289nem.1 uc289nem.2 uc289nem.3 
ENSMUST00000234365.3 Cyp4f41-ps ENSMUST00000234365.3 Cyp4f41-ps (from geneSymbol) AK020053 ENSMUST00000234365.1 ENSMUST00000234365.2 uc289jti.1 uc289jti.2 uc289jti.3 uc289jti.1 uc289jti.2 uc289jti.3 
ENSMUST00000234374.2 Gm50023 ENSMUST00000234374.2 Gm50023 (from geneSymbol) ENSMUST00000234374.1 uc289nqv.1 uc289nqv.2 uc289nqv.1 uc289nqv.2 
ENSMUST00000234389.2 Gm4710 ENSMUST00000234389.2 predicted gene 4710 (from RefSeq NR_033456.1) ENSMUST00000234389.1 NR_033456 uc008dos.1 uc008dos.2 uc008dos.1 uc008dos.2 
ENSMUST00000234394.2 Gm19696 ENSMUST00000234394.2 Gm19696 (from geneSymbol) ENSMUST00000234394.1 uc289nfa.1 uc289nfa.2 uc289nfa.1 uc289nfa.2 
ENSMUST00000234398.2 Gm50051 ENSMUST00000234398.2 Gm50051 (from geneSymbol) ENSMUST00000234398.1 uc289jsk.1 uc289jsk.2 uc289jsk.1 uc289jsk.2 
ENSMUST00000234404.2 Gm50062 ENSMUST00000234404.2 Gm50062 (from geneSymbol) ENSMUST00000234404.1 uc289hzy.1 uc289hzy.2 uc289hzy.1 uc289hzy.2 
ENSMUST00000234417.2 Gm50035 ENSMUST00000234417.2 Gm50035 (from geneSymbol) AK040064 ENSMUST00000234417.1 uc289ofb.1 uc289ofb.2 uc289ofb.1 uc289ofb.2 
ENSMUST00000234429.2 Gm50057 ENSMUST00000234429.2 Gm50057 (from geneSymbol) ENSMUST00000234429.1 uc289hvr.1 uc289hvr.2 uc289hvr.1 uc289hvr.2 
ENSMUST00000234442.2 Gm41654 ENSMUST00000234442.2 Gm41654 (from geneSymbol) ENSMUST00000234442.1 uc289nmt.1 uc289nmt.2 uc289nmt.1 uc289nmt.2 
ENSMUST00000234445.2 4933424G05Rik ENSMUST00000234445.2 RIKEN cDNA 4933424G05 gene (from RefSeq NR_045372.1) ENSMUST00000234445.1 NR_045372 uc029tlv.1 uc029tlv.2 uc029tlv.1 uc029tlv.2 
ENSMUST00000234469.2 Gm41662 ENSMUST00000234469.2 Gm41662 (from geneSymbol) AK087733 ENSMUST00000234469.1 uc289nsl.1 uc289nsl.2 uc289nsl.1 uc289nsl.2 
ENSMUST00000234471.2 Gm49985 ENSMUST00000234471.2 Gm49985 (from geneSymbol) ENSMUST00000234471.1 uc289nav.1 uc289nav.2 uc289nav.1 uc289nav.2 
ENSMUST00000234477.3 Tpsb2 ENSMUST00000234477.3 Tpsb2 (from geneSymbol) E9QJW9 E9QJW9_MOUSE ENSMUST00000234477.1 ENSMUST00000234477.2 M57626 Tpsb2 uc008bas.1 uc008bas.2 uc008bas.3 uc008bas.4 serine-type endopeptidase activity proteolysis peptidase activity serine-type peptidase activity hydrolase activity uc008bas.1 uc008bas.2 uc008bas.3 uc008bas.4 
ENSMUST00000234482.2 Gm50008 ENSMUST00000234482.2 Gm50008 (from geneSymbol) AK087161 ENSMUST00000234482.1 uc289nhp.1 uc289nhp.2 uc289nhp.1 uc289nhp.2 
ENSMUST00000234487.2 Gm50048 ENSMUST00000234487.2 Gm50048 (from geneSymbol) AK140437 ENSMUST00000234487.1 uc008edu.1 uc008edu.2 uc008edu.1 uc008edu.2 
ENSMUST00000234495.2 Gm50080 ENSMUST00000234495.2 Gm50080 (from geneSymbol) AK135378 ENSMUST00000234495.1 uc289nwi.1 uc289nwi.2 uc289nwi.1 uc289nwi.2 
ENSMUST00000234513.3 Gm4719 ENSMUST00000234513.3 predicted gene 4719 (from RefSeq NR_045952.1) ENSMUST00000234513.1 ENSMUST00000234513.2 NR_045952 uc029tlh.1 uc029tlh.2 uc029tlh.3 uc029tlh.1 uc029tlh.2 uc029tlh.3 
ENSMUST00000234517.3 Nfilz ENSMUST00000234517.3 NFIL3 like basic leucine zipper (from RefSeq NM_001401239.1) A0A5F8MPM5 A0A5F8MPM5_MOUSE ENSMUST00000234517.1 ENSMUST00000234517.2 Gm4125 NM_001401239 Nfilz uc289juk.1 uc289juk.2 uc289juk.3 Belongs to the bZIP family. NFIL3 subfamily. uc289juk.1 uc289juk.2 uc289juk.3 
ENSMUST00000234542.3 Gm50086 ENSMUST00000234542.3 Gm50086 (from geneSymbol) ENSMUST00000234542.1 ENSMUST00000234542.2 uc289pby.1 uc289pby.2 uc289pby.3 uc289pby.1 uc289pby.2 uc289pby.3 
ENSMUST00000234553.2 ENSMUSG00000121617 ENSMUST00000234553.2 ENSMUSG00000121617 (from geneSymbol) ENSMUST00000234553.1 uc289ogi.1 uc289ogi.2 uc289ogi.1 uc289ogi.2 
ENSMUST00000234567.2 Gm49972 ENSMUST00000234567.2 Gm49972 (from geneSymbol) ENSMUST00000234567.1 uc289pau.1 uc289pau.2 uc289pau.1 uc289pau.2 
ENSMUST00000234569.2 Gm50034 ENSMUST00000234569.2 Gm50034 (from geneSymbol) ENSMUST00000234569.1 uc289myt.1 uc289myt.2 uc289myt.1 uc289myt.2 
ENSMUST00000234570.3 Gm49976 ENSMUST00000234570.3 Gm49976 (from geneSymbol) AK015494 ENSMUST00000234570.1 ENSMUST00000234570.2 uc289okw.1 uc289okw.2 uc289okw.3 uc289okw.1 uc289okw.2 uc289okw.3 
ENSMUST00000234572.3 Gm50065 ENSMUST00000234572.3 Gm50065 (from geneSymbol) ENSMUST00000234572.1 ENSMUST00000234572.2 uc289nrp.1 uc289nrp.2 uc289nrp.3 uc289nrp.1 uc289nrp.2 uc289nrp.3 
ENSMUST00000234580.2 C330024C12Rik ENSMUST00000234580.2 RIKEN cDNA C330024C12 gene (from RefSeq NR_046016.1) ENSMUST00000234580.1 NR_046016 uc029tld.1 uc029tld.2 uc029tld.1 uc029tld.2 
ENSMUST00000234586.2 Gm50096 ENSMUST00000234586.2 Gm50096 (from geneSymbol) AK014726 ENSMUST00000234586.1 uc289nqn.1 uc289nqn.2 uc289nqn.1 uc289nqn.2 
ENSMUST00000234587.2 Gm50050 ENSMUST00000234587.2 Gm50050 (from geneSymbol) ENSMUST00000234587.1 uc289jsi.1 uc289jsi.2 uc289jsi.1 uc289jsi.2 
ENSMUST00000234588.2 4930578E11Rik ENSMUST00000234588.2 RIKEN cDNA 4930578E11 gene (from RefSeq NR_045391.1) ENSMUST00000234588.1 NR_045391 uc008ehu.1 uc008ehu.2 uc008ehu.1 uc008ehu.2 
ENSMUST00000234591.2 Gm50044 ENSMUST00000234591.2 Gm50044 (from geneSymbol) ENSMUST00000234591.1 uc289ndb.1 uc289ndb.2 uc289ndb.1 uc289ndb.2 
ENSMUST00000234602.2 Cdkl4 ENSMUST00000234602.2 cyclin dependent kinase like 4, transcript variant 1 (from RefSeq NM_001360144.1) B2RSS7 CDKL4_MOUSE ENSMUST00000234602.1 Gm942 NM_001360144 Q3TZA2 uc289ncl.1 uc289ncl.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Cytoplasm The [NKR]KIAxRE motif seems to be a cyclin-binding region. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity regulation of cell cycle uc289ncl.1 uc289ncl.2 
ENSMUST00000234603.2 Gm41653 ENSMUST00000234603.2 Gm41653 (from geneSymbol) ENSMUST00000234603.1 uc289nli.1 uc289nli.2 uc289nli.1 uc289nli.2 
ENSMUST00000234604.5 Gm33727 ENSMUST00000234604.5 Gm33727 (from geneSymbol) ENSMUST00000234604.1 ENSMUST00000234604.2 ENSMUST00000234604.3 ENSMUST00000234604.4 uc289ijj.1 uc289ijj.2 uc289ijj.3 uc289ijj.4 uc289ijj.5 uc289ijj.1 uc289ijj.2 uc289ijj.3 uc289ijj.4 uc289ijj.5 
ENSMUST00000234617.2 2010106G04Rik ENSMUST00000234617.2 2010106G04Rik (from geneSymbol) AK008322 ENSMUST00000234617.1 uc289jkz.1 uc289jkz.2 uc289jkz.1 uc289jkz.2 
ENSMUST00000234633.2 Hspe1-rs1 ENSMUST00000234633.2 Belongs to the GroES chaperonin family. (from UniProt Q9JI95) Cpn10-rs1 ENSMUST00000234633.1 Hspe1-rs1 Q9JI95 Q9JI95_MOUSE uc289pbl.1 uc289pbl.2 Belongs to the GroES chaperonin family. mitochondrion protein folding female pregnancy growth factor activity uc289pbl.1 uc289pbl.2 
ENSMUST00000234637.2 1810014P07Rik ENSMUST00000234637.2 1810014P07Rik (from geneSymbol) AK007501 ENSMUST00000234637.1 uc289jmh.1 uc289jmh.2 uc289jmh.1 uc289jmh.2 
ENSMUST00000234668.2 Gm49991 ENSMUST00000234668.2 Gm49991 (from geneSymbol) ENSMUST00000234668.1 uc289nmn.1 uc289nmn.2 uc289nmn.1 uc289nmn.2 
ENSMUST00000234677.3 Gm30091 ENSMUST00000234677.3 Gm30091 (from geneSymbol) ENSMUST00000234677.1 ENSMUST00000234677.2 uc289mri.1 uc289mri.2 uc289mri.3 uc289mri.1 uc289mri.2 uc289mri.3 
ENSMUST00000234689.2 Gm49978 ENSMUST00000234689.2 Gm49978 (from geneSymbol) ENSMUST00000234689.1 uc289olc.1 uc289olc.2 uc289olc.1 uc289olc.2 
ENSMUST00000234695.2 Gm50017 ENSMUST00000234695.2 Gm50017 (from geneSymbol) ENSMUST00000234695.1 uc289jmt.1 uc289jmt.2 uc289jmt.1 uc289jmt.2 
ENSMUST00000234698.2 Gm50012 ENSMUST00000234698.2 Gm50012 (from geneSymbol) ENSMUST00000234698.1 uc289nhw.1 uc289nhw.2 uc289nhw.1 uc289nhw.2 
ENSMUST00000234702.3 Gm50049 ENSMUST00000234702.3 Gm50049 (from geneSymbol) ENSMUST00000234702.1 ENSMUST00000234702.2 uc289ohh.1 uc289ohh.2 uc289ohh.3 uc289ohh.1 uc289ohh.2 uc289ohh.3 
ENSMUST00000234706.2 Gm50024 ENSMUST00000234706.2 Gm50024 (from geneSymbol) ENSMUST00000234706.1 uc289nqx.1 uc289nqx.2 uc289nqx.1 uc289nqx.2 
ENSMUST00000234707.4 Gm30117 ENSMUST00000234707.4 Gm30117 (from geneSymbol) ENSMUST00000234707.1 ENSMUST00000234707.2 ENSMUST00000234707.3 uc289nhf.1 uc289nhf.2 uc289nhf.3 uc289nhf.4 uc289nhf.1 uc289nhf.2 uc289nhf.3 uc289nhf.4 
ENSMUST00000234711.2 BC004004 ENSMUST00000234711.2 cDNA sequence BC004004, transcript variant 3 (from RefSeq NM_001379078.1) CF089_MOUSE ENSMUST00000234711.1 NM_001379078 Q6PDQ4 Q7TSE2 Q7TSE4 Q8BST4 Q99KU6 uc289jgi.1 uc289jgi.2 Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells. Homodimer (By similarity). Interacts with BRS3. Interacts (via N-terminus) with SIN3B. Golgi apparatus membrane ; Single-pass type II membrane protein Cytoplasm Glycosylated. Sequence=AAP45201.1; Type=Erroneous gene model prediction; Evidence=; Golgi membrane molecular_function nucleolus cytoplasm Golgi apparatus plasma membrane membrane integral component of membrane midbody wound healing positive regulation of cell cycle epithelial cell proliferation positive regulation of histone deacetylase activity uc289jgi.1 uc289jgi.2 
ENSMUST00000234727.2 4921533I20Rik ENSMUST00000234727.2 4921533I20Rik (from geneSymbol) AK076609 ENSMUST00000234727.1 uc012bac.1 uc012bac.2 uc012bac.3 uc012bac.1 uc012bac.2 uc012bac.3 
ENSMUST00000234735.2 Cabyr ENSMUST00000234735.2 May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. May bind calcium in vitro (By similarity). (from UniProt Q9D424) AF359383 CABYR_MOUSE Cbp86 ENSMUST00000234735.1 Q91Y41 Q91Y42 Q9D424 uc289ocf.1 uc289ocf.2 May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. May bind calcium in vitro (By similarity). Interacts with FSCB. Cytoplasm Cytoplasm, cytoskeleton Cell projection, cilium, flagellum Note=Localizes to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CBP86-1, CBP86-6; IsoId=Q9D424-1; Sequence=Displayed; Name=2; Synonyms=CBP86-2; IsoId=Q9D424-2; Sequence=VSP_016252, VSP_016255; Name=3; Synonyms=CBP86-4; IsoId=Q9D424-3; Sequence=VSP_016253, VSP_016254; Expressed in spermatozoa. Phosphorylated on tyrosine residues during in vitro capacitation. Dephosphorylation affects its ability to bind calcium (By similarity). calcium ion binding protein binding nucleus cytoplasm cytosol cytoskeleton cilium calcium-mediated signaling enzyme binding protein domain specific binding motile cilium sperm fibrous sheath cell projection metal ion binding protein heterodimerization activity sperm capacitation sperm principal piece sperm end piece uc289ocf.1 uc289ocf.2 
ENSMUST00000234736.2 Ccdc178 ENSMUST00000234736.2 Ccdc178 (from geneSymbol) AK029534 B7ZN78 CC178_MOUSE ENSMUST00000234736.1 Q8CDV0 uc012baf.1 uc012baf.2 uc012baf.3 molecular_function cellular_component biological_process uc012baf.1 uc012baf.2 uc012baf.3 
ENSMUST00000234740.2 Gm33508 ENSMUST00000234740.2 predicted gene, 33508 (from RefSeq NR_169077.1) ENSMUST00000234740.1 NR_169077 uc289ibf.1 uc289ibf.2 uc289ibf.1 uc289ibf.2 
ENSMUST00000234745.2 Gm50091 ENSMUST00000234745.2 Gm50091 (from geneSymbol) AK034630 ENSMUST00000234745.1 uc056zfo.1 uc056zfo.2 uc056zfo.1 uc056zfo.2 
ENSMUST00000234755.2 Gm50078 ENSMUST00000234755.2 Gm50078 (from geneSymbol) ENSMUST00000234755.1 LF201303 uc289nwj.1 uc289nwj.2 uc289nwj.1 uc289nwj.2 
ENSMUST00000234765.2 Prss30 ENSMUST00000234765.2 Selectively cleaves synthetic peptide substrates of trypsin. Activates the epithelial sodium channel ENaC (By similarity). (from UniProt Q9QYZ9) BC040348 Disp ENSMUST00000234765.1 PRS30_MOUSE Q91XC4 Q9QYZ9 Tmprss8 uc289hwe.1 uc289hwe.2 Selectively cleaves synthetic peptide substrates of trypsin. Activates the epithelial sodium channel ENaC (By similarity). Inhibited by aprotinin, leupeptin, benzamidine and soybean trypsin inhibitor. Partially inhibited by PMSF and DFP (By similarity). Cell membrane ; Lipid-anchor, GPI- anchor Expressed primarily in distal gut. Belongs to the peptidase S1 family. serine-type endopeptidase activity extracellular space plasma membrane proteolysis ion transport sodium ion transport peptidase activity serine-type peptidase activity membrane hydrolase activity sodium channel regulator activity anchored component of membrane uc289hwe.1 uc289hwe.2 
ENSMUST00000234767.2 Gm50079 ENSMUST00000234767.2 Gm50079 (from geneSymbol) AK050910 ENSMUST00000234767.1 uc289nwn.1 uc289nwn.2 uc289nwn.1 uc289nwn.2 
ENSMUST00000234768.3 4833419F23Rik ENSMUST00000234768.3 4833419F23Rik (from geneSymbol) AK014726 ENSMUST00000234768.1 ENSMUST00000234768.2 uc289nqo.1 uc289nqo.2 uc289nqo.3 uc289nqo.1 uc289nqo.2 uc289nqo.3 
ENSMUST00000234780.2 Gm50033 ENSMUST00000234780.2 Gm50033 (from geneSymbol) AK038355 ENSMUST00000234780.1 uc289nya.1 uc289nya.2 uc289nya.1 uc289nya.2 
ENSMUST00000234781.2 Gm50092 ENSMUST00000234781.2 Gm50092 (from geneSymbol) A0A3Q4EGK1 A0A3Q4EGK1_MOUSE ENSMUST00000234781.1 Gm50092 LF196114 uc291muv.1 uc291muv.2 uc291muv.1 uc291muv.2 
ENSMUST00000234784.2 Gm35031 ENSMUST00000234784.2 predicted gene, 35031 (from RefSeq NR_188911.1) ENSMUST00000234784.1 NR_188911 uc289nvk.1 uc289nvk.2 uc289nvk.1 uc289nvk.2 
ENSMUST00000234788.2 Odad2 ENSMUST00000234788.2 outer dynein arm docking complex subunit 2 (from RefSeq NM_001357492.1) Armc4 B2RY50 ENSMUST00000234788.1 NM_001357492 ODAD2_MOUSE Odad2 Q9CUL6 uc008dzr.1 uc008dzr.2 uc008dzr.3 uc008dzr.4 Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule (By similarity). Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (PubMed:23849778). Component of the outer dynein arm-docking complex along with ODAD1, ODAD3, and ODAD4. Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, cilium basal body Highly expressed in testis. In males, also detected at lower levels in lung, brain, liver and muscle. In females, detected in ovary. At 7.5 dpc, expressed in the ventral node. cilium movement regulation of cilium beat frequency molecular_function cytoplasm cytoskeleton cilium axoneme determination of left/right symmetry heart development ventricular system development cell projection organization outer dynein arm assembly cell projection ciliary base uc008dzr.1 uc008dzr.2 uc008dzr.3 uc008dzr.4 
ENSMUST00000234789.2 Taf4b ENSMUST00000234789.2 TATA-box binding protein associated factor 4b, transcript variant 3 (from RefSeq NM_001369358.1) A0A3Q4EGS4 A0A3Q4EGS4_MOUSE ENSMUST00000234789.1 NM_001369358 Taf4b uc289oes.1 uc289oes.2 Nucleus Belongs to the TAF4 family. transcription factor activity, sequence-specific DNA binding transcription factor TFIID complex DNA-templated transcription, initiation regulation of transcription, DNA-templated protein heterodimerization activity uc289oes.1 uc289oes.2 
ENSMUST00000234807.2 Gm50011 ENSMUST00000234807.2 Gm50011 (from geneSymbol) ENSMUST00000234807.1 uc289nht.1 uc289nht.2 uc289nht.1 uc289nht.2 
ENSMUST00000234810.2 Rab18 ENSMUST00000234810.2 RAB18, member RAS oncogene family, transcript variant 2 (from RefSeq NM_181070.6) ENSMUST00000234810.1 NM_181070 Q0PD38 Q0PD38_MOUSE Rab18 uc008dzo.1 uc008dzo.2 uc008dzo.3 uc008dzo.4 This gene encodes a member of the Ras-related small GTPases, which regulate membrane trafficking in organelles and transport vesicles. This protein is expressed predominantly in lipid droplets, organelles that store neutral lipids, and is proposed to play a role in lipolysis and lipogenesis. In humans mutations in this gene are associated with Warburg micro syndrome type 3. A pseudogene of this gene is located on chromosome X. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]. Apical cell membrane Lipid droplet GTPase activity GTP binding GDP binding lipid particle organization synapse endoplasmic reticulum tubular network endoplasmic reticulum tubular network organization uc008dzo.1 uc008dzo.2 uc008dzo.3 uc008dzo.4 
ENSMUST00000234824.2 Gm49999 ENSMUST00000234824.2 Gm49999 (from geneSymbol) ENSMUST00000234824.1 uc289jph.1 uc289jph.2 uc289jph.1 uc289jph.2 
ENSMUST00000234828.2 Gm49968 ENSMUST00000234828.2 Gm49968 (from geneSymbol) ENSMUST00000234828.1 uc289nzy.1 uc289nzy.2 uc289nzy.1 uc289nzy.2 
ENSMUST00000234829.2 ENSMUSG00000121766 ENSMUST00000234829.2 ENSMUSG00000121766 (from geneSymbol) AK135754 ENSMUST00000234829.1 uc289nxx.1 uc289nxx.2 uc289nxx.1 uc289nxx.2 
ENSMUST00000234831.2 Gm50084 ENSMUST00000234831.2 Gm50084 (from geneSymbol) ENSMUST00000234831.1 uc289ogf.1 uc289ogf.2 uc289ogf.1 uc289ogf.2 
ENSMUST00000234840.2 Gm50015 ENSMUST00000234840.2 Gm50015 (from geneSymbol) ENSMUST00000234840.1 uc289ipv.1 uc289ipv.2 uc289ipv.1 uc289ipv.2 
ENSMUST00000234850.2 ENSMUSG00000121455 ENSMUST00000234850.2 ENSMUSG00000121455 (from geneSymbol) AK049221 ENSMUST00000234850.1 uc007qzo.1 uc007qzo.2 uc007qzo.3 uc007qzo.1 uc007qzo.2 uc007qzo.3 
ENSMUST00000234858.2 Gm50025 ENSMUST00000234858.2 Gm50025 (from geneSymbol) ENSMUST00000234858.1 uc289ijk.1 uc289ijk.2 uc289ijk.1 uc289ijk.2 
ENSMUST00000234877.2 Gm50055 ENSMUST00000234877.2 Gm50055 (from geneSymbol) ENSMUST00000234877.1 LF201301 uc289nvy.1 uc289nvy.2 uc289nvy.1 uc289nvy.2 
ENSMUST00000234897.3 Gm31759 ENSMUST00000234897.3 predicted gene, 31759 (from RefSeq NR_168504.1) ENSMUST00000234897.1 ENSMUST00000234897.2 NR_168504 uc289mxb.1 uc289mxb.2 uc289mxb.3 uc289mxb.1 uc289mxb.2 uc289mxb.3 
ENSMUST00000234910.2 Arl14epl ENSMUST00000234910.2 ADP-ribosylation factor-like 14 effector protein-like (from RefSeq NM_001033446.2) A14EL_MOUSE ENSMUST00000234910.1 Gm949 NM_001033446 Q3UKZ7 uc008evy.1 uc008evy.2 uc008evy.3 molecular_function cellular_component biological_process uc008evy.1 uc008evy.2 uc008evy.3 
ENSMUST00000234919.2 Gm50016 ENSMUST00000234919.2 Gm50016 (from geneSymbol) ENSMUST00000234919.1 uc289jmi.1 uc289jmi.2 uc289jmi.1 uc289jmi.2 
ENSMUST00000234934.2 Gm50039 ENSMUST00000234934.2 Gm50039 (from geneSymbol) ENSMUST00000234934.1 uc289njs.1 uc289njs.2 uc289njs.1 uc289njs.2 
ENSMUST00000234935.2 ENSMUSG00000121450 ENSMUST00000234935.2 ENSMUSG00000121450 (from geneSymbol) ENSMUST00000234935.1 uc289jsg.1 uc289jsg.2 uc289jsg.1 uc289jsg.2 
ENSMUST00000234938.2 Gm38410 ENSMUST00000234938.2 predicted gene, 38410 (from RefSeq NR_152129.1) ENSMUST00000234938.1 NR_152129 uc289ojg.1 uc289ojg.2 uc289ojg.1 uc289ojg.2 
ENSMUST00000234953.2 Gm34804 ENSMUST00000234953.2 Gm34804 (from geneSymbol) ENSMUST00000234953.1 uc289nsk.1 uc289nsk.2 uc289nsk.1 uc289nsk.2 
ENSMUST00000234954.2 Gm50094 ENSMUST00000234954.2 Gm50094 (from geneSymbol) AK050777 ENSMUST00000234954.1 uc289odx.1 uc289odx.2 uc289odx.1 uc289odx.2 
ENSMUST00000234958.3 Gm20161 ENSMUST00000234958.3 predicted gene, 20161 (from RefSeq NR_167666.2) ENSMUST00000234958.1 ENSMUST00000234958.2 NR_167666 uc008btg.1 uc008btg.2 uc008btg.3 uc008btg.4 uc008btg.1 uc008btg.2 uc008btg.3 uc008btg.4 
ENSMUST00000234965.2 Colec12 ENSMUST00000234965.2 collectin sub-family member 12 (from RefSeq NM_130449.2) COL12_MOUSE Clp1 ENSMUST00000234965.1 NM_130449 Q3TYT8 Q8C979 Q8K4Q8 Q8VIF6 Srcl uc008eak.1 uc008eak.2 uc008eak.3 uc008eak.4 Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells (By similarity). Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells (By similarity). The extracellular domain forms a stable trimer (By similarity). The extracellular domain interacts with fibrillar amyloid- beta peptide. Membrane ; Single-pass type II membrane protein Note=Forms clusters on the cell surface. Expressed in vascular endothelial cells in the heart, in perivascular macrophage and smooth muscle cells. Expressed in plaques-surrounding reactive astrocytes located in cerebral cortex and hippocampus and in leptomeningeal vessels showing characteristics of cerebral amyloid angiopathy (CAA) in a double transgenic mouse model of Alzheimer disease (at protein level). Strongly expressed in lung. Moderately expressed in heart, skeletal muscle, spleen, liver, brain, colon, testis, stomach and kidney. Expressed in neonatal astrocytes. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of a double transgenic mouse model of Alzheimer disease. Expressed in embryo at 9 dpc, increases progressively to a peak at 14 dpc and gradually decreases until 19 dpc. Up-regulated in activated microglia and by fibrillar amyloid-beta peptide in activated astrocytes. transmembrane signaling receptor activity collagen trimer phagocytosis, recognition immune response signaling pattern recognition receptor activity membrane integral component of membrane low-density lipoprotein particle binding carbohydrate binding toll-like receptor 3 signaling pathway metal ion binding positive regulation of cell adhesion molecule production uc008eak.1 uc008eak.2 uc008eak.3 uc008eak.4 
ENSMUST00000234966.2 Ttc39c ENSMUST00000234966.2 tetratricopeptide repeat domain 39C (from RefSeq NM_028341.5) A0A3Q4EGC9 A0A3Q4EGC9_MOUSE ENSMUST00000234966.1 NM_028341 Ttc39c uc008ecj.1 uc008ecj.2 uc008ecj.3 uc008ecj.4 Belongs to the TTC39 family. uc008ecj.1 uc008ecj.2 uc008ecj.3 uc008ecj.4 
ENSMUST00000234973.2 Gm50061 ENSMUST00000234973.2 Gm50061 (from geneSymbol) ENSMUST00000234973.1 EU234016 uc289nlg.1 uc289nlg.2 uc289nlg.1 uc289nlg.2 
ENSMUST00000234983.2 Gm49979 ENSMUST00000234983.2 Gm49979 (from geneSymbol) ENSMUST00000234983.1 uc289ngb.1 uc289ngb.2 uc289ngb.1 uc289ngb.2 
ENSMUST00000234987.3 4930545E07Rik ENSMUST00000234987.3 RIKEN cDNA 4930545E07 gene (from RefSeq NR_045374.1) ENSMUST00000234987.1 ENSMUST00000234987.2 NR_045374 uc029tly.1 uc029tly.2 uc029tly.3 uc029tly.1 uc029tly.2 uc029tly.3 
ENSMUST00000234989.3 4933400B14Rik ENSMUST00000234989.3 RIKEN cDNA 4933400B14 gene (from RefSeq NR_045432.1) ENSMUST00000234989.1 ENSMUST00000234989.2 NR_045432 uc029tlg.1 uc029tlg.2 uc029tlg.3 uc029tlg.1 uc029tlg.2 uc029tlg.3 
ENSMUST00000234990.2 Mettl4 ENSMUST00000234990.2 methyltransferase 4, N6-adenosine, transcript variant 3 (from RefSeq NM_176917.5) ENSMUST00000234990.1 METL4_MOUSE Mettl4 NM_176917 Q3U034 uc008dwk.1 uc008dwk.2 uc008dwk.3 N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA (PubMed:30982744). Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O- dimethyladenosine (m6A(m)) on internal positions of U2 small nuclear RNA (snRNA): methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation (By similarity). Internal m6A(m) methylation of snRNAs regulates RNA splicing (By similarity). Also able to act as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)- methyladenosine) (PubMed:30982744). The existence of N(6)- methyladenosine (m6A) on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N(6)- adenine-specific DNA methyltransferase activity of METTL4 in vivo (By similarity). Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA) copy number by mediating mtDNA N(6)- methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA- binding and bending (By similarity). N(6)-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (PubMed:30982744). Reaction=a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl- L-homocysteine; Xref=Rhea:RHEA:62672, Rhea:RHEA-COMP:16150, Rhea:RHEA-COMP:16151, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74477, ChEBI:CHEBI:145853; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62673; Evidence=; Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA- COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15198; Evidence=; Nucleus Embryonic sublethality and craniofacial dysmorphism (PubMed:30982744). Surviving mice display anatomical defects, including anophthalmia and craniofacial dysmorphism (PubMed:30982744). Adult mice are moribund and exhibited splenomegaly with anemia and severe leukopenia, indicative of aberrant hematopoiesis (PubMed:30982744). Belongs to the MT-A70-like family. The existence of N(6)-methyladenosine on DNA is unclear in mammals (By similarity). According to a report, the majority of N(6)- methyladenosine in DNA originates from RNA catabolism via a nucleotide salvage pathway and is misincorporated by DNA polymerases, arguing against a role as epigenetic DNA mark in mammalian cells (By similarity). Additional evidences are therefore required to confirm the role of METTL4 as a N(6)-adenine-specific DNA methyltransferase in vivo (By similarity). nucleic acid binding nucleus biological_process methyltransferase activity site-specific DNA-methyltransferase (adenine-specific) activity transferase activity methylation DNA methylation on adenine uc008dwk.1 uc008dwk.2 uc008dwk.3 
ENSMUST00000234992.2 Gm46587 ENSMUST00000234992.2 Gm46587 (from geneSymbol) ENSMUST00000234992.1 uc289nji.1 uc289nji.2 uc289nji.1 uc289nji.2 
ENSMUST00000234996.2 Gm50081 ENSMUST00000234996.2 Gm50081 (from geneSymbol) ENSMUST00000234996.1 uc289ntt.1 uc289ntt.2 uc289ntt.1 uc289ntt.2 
ENSMUST00000235009.4 Gm31645 ENSMUST00000235009.4 Gm31645 (from geneSymbol) ENSMUST00000235009.1 ENSMUST00000235009.2 ENSMUST00000235009.3 uc289mvv.1 uc289mvv.2 uc289mvv.3 uc289mvv.4 uc289mvv.1 uc289mvv.2 uc289mvv.3 uc289mvv.4 
ENSMUST00000235010.2 Gm50069 ENSMUST00000235010.2 Gm50069 (from geneSymbol) BC060148 ENSMUST00000235010.1 uc289nzn.1 uc289nzn.2 uc289nzn.1 uc289nzn.2 
ENSMUST00000235017.2 Sap130 ENSMUST00000235017.2 Sin3A associated protein, transcript variant 2 (from RefSeq NM_001357554.2) ENSMUST00000235017.1 NM_001357554 Q6NZP5 Q6P553 Q8BID9 Q8BIH0 Q9CSU1 SP130_MOUSE uc008eid.1 uc008eid.2 uc008eid.3 Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2 (By similarity). Interacts (released by dead or dying cells) with CLEC4E. Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BIH0-1; Sequence=Displayed; Name=2; IsoId=Q8BIH0-2; Sequence=VSP_024357; Name=3; IsoId=Q8BIH0-3; Sequence=VSP_024358, VSP_024359; The N-terminus may interact with a transcriptional coactivator. The C-terminus may interact with HDAC-dependent and HDAC- independent corepressors. Acetylated. Sumoylated with SUMO1. Belongs to the SAP130 family. Sequence=AAH66030.1; Type=Erroneous initiation; Evidence=; negative regulation of transcription from RNA polymerase II promoter protein binding nucleus regulation of transcription, DNA-templated nuclear speck Sin3-type complex uc008eid.1 uc008eid.2 uc008eid.3 
ENSMUST00000235047.2 Sbpl ENSMUST00000235047.2 spermine binding protein-like (from RefSeq NM_001077421.1) ENSMUST00000235047.1 NM_001077421 Q3TUY3 Q3TUY3_MOUSE Sbp Sbpl uc008aud.1 uc008aud.2 uc008aud.3 molecular_function extracellular space biological_process uc008aud.1 uc008aud.2 uc008aud.3 
ENSMUST00000235062.2 Tmem217 ENSMUST00000235062.2 Tmem217 (from geneSymbol) 4933413N12Rik AK016810 ENSMUST00000235062.1 Q14AF1 Q14AF1_MOUSE Tmem217 uc289jku.1 uc289jku.2 fibrillar center molecular_function nucleolus biological_process membrane integral component of membrane uc289jku.1 uc289jku.2 
ENSMUST00000235073.2 CJ186046Rik ENSMUST00000235073.2 CJ186046Rik (from geneSymbol) ENSMUST00000235073.1 uc289nhd.1 uc289nhd.2 uc289nhd.1 uc289nhd.2 
ENSMUST00000235083.4 Gm50097 ENSMUST00000235083.4 Gm50097 (from geneSymbol) ENSMUST00000235083.1 ENSMUST00000235083.2 ENSMUST00000235083.3 uc289oeb.1 uc289oeb.2 uc289oeb.3 uc289oeb.4 uc289oeb.1 uc289oeb.2 uc289oeb.3 uc289oeb.4 
ENSMUST00000235086.2 Cyp4f40 ENSMUST00000235086.2 cytochrome P450, family 4, subfamily f, polypeptide 40, transcript variant 2 (from RefSeq NM_001368735.1) Cyp4f40 ENSMUST00000235086.1 G3UW81 G3UW81_MOUSE NM_001368735 uc289jro.1 uc289jro.2 Belongs to the cytochrome P450 family. monooxygenase activity fatty acid binding iron ion binding cellular_component fatty acid metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen heme binding menaquinone catabolic process phylloquinone catabolic process vitamin K catabolic process metal ion binding oxidation-reduction process uc289jro.1 uc289jro.2 
ENSMUST00000235087.2 Gm50026 ENSMUST00000235087.2 Gm50026 (from geneSymbol) ENSMUST00000235087.1 uc289ijn.1 uc289ijn.2 uc289ijn.1 uc289ijn.2 
ENSMUST00000235091.2 Gm50054 ENSMUST00000235091.2 Gm50054 (from geneSymbol) ENSMUST00000235091.1 LF227667 uc289jga.1 uc289jga.2 uc289jga.1 uc289jga.2 
ENSMUST00000235108.2 Gm49981 ENSMUST00000235108.2 Gm49981 (from geneSymbol) ENSMUST00000235108.1 uc289ngc.1 uc289ngc.2 uc289ngc.1 uc289ngc.2 
ENSMUST00000235110.2 Atp6v1e2 ENSMUST00000235110.2 Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. (from UniProt Q9D593) Atp6e1 BC061059 ENSMUST00000235110.1 Q6P8U8 Q810S5 Q9D593 VATE2_MOUSE uc289nhu.1 uc289nhu.2 Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Testis specific. Belongs to the V-ATPase E subunit family. acrosomal vesicle ion transport hydrogen-exporting ATPase activity, phosphorylative mechanism proton-transporting two-sector ATPase complex, catalytic domain proton-transporting ATPase activity, rotational mechanism hydrogen ion transmembrane transport uc289nhu.1 uc289nhu.2 
ENSMUST00000235141.2 1500015L24Rik ENSMUST00000235141.2 1500015L24Rik (from geneSymbol) AK005254 ENSMUST00000235141.1 uc294edm.1 uc294edm.2 uc294edm.1 uc294edm.2 
ENSMUST00000235148.2 Gm50216 ENSMUST00000235148.2 Gm50216 (from geneSymbol) ENSMUST00000235148.1 uc294edt.1 uc294edt.2 uc294edt.1 uc294edt.2 
ENSMUST00000235154.2 Gm50375 ENSMUST00000235154.2 Gm50375 (from geneSymbol) ENSMUST00000235154.1 uc294edz.1 uc294edz.2 uc294edz.1 uc294edz.2 
ENSMUST00000235158.3 Gm50105 ENSMUST00000235158.3 Gm50105 (from geneSymbol) ENSMUST00000235158.1 ENSMUST00000235158.2 uc294eed.1 uc294eed.2 uc294eed.3 uc294eed.1 uc294eed.2 uc294eed.3 
ENSMUST00000235179.2 Gm32932 ENSMUST00000235179.2 Gm32932 (from geneSymbol) AK076746 ENSMUST00000235179.1 uc294eex.1 uc294eex.2 uc294eex.1 uc294eex.2 
ENSMUST00000235196.2 Fth1 ENSMUST00000235196.2 ferritin heavy polypeptide 1, transcript variant 2 (from RefSeq NR_073181.1) ENSMUST00000235196.1 FRIH_MOUSE Fth NR_073181 P09528 Q3UI44 uc294efn.1 uc294efn.2 Stores iron in a soluble, non-toxic, readily available form (By similarity). Important for iron homeostasis (By similarity). Has ferroxidase activity (By similarity). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Also plays a role in delivery of iron to cells (PubMed:19154717). Mediates iron uptake in capsule cells of the developing kidney (PubMed:19154717). Reaction=4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O; Xref=Rhea:RHEA:11148, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.16.3.1; Evidence=; Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. P09528; P09528: Fth1; NbExp=3; IntAct=EBI-308950, EBI-308950; Cytoplasm At 9.5 dpc, detected at low levels in the developing heart and central nervous system. At later stages of development, widely expressed, predominantly in the heart and brown fat tissue. Homozygous mutant embryos die in utero between 3.5 and 9.5 dpc (PubMed:10652280). Heterozygous animals are healthy and fertile and do not present any apparent abnormalities. They show slightly elevated tissue light chain ferritin content and 7- to 10-fold more light chain ferritin in the serum than normal mice, but their serum iron remains unchanged. Belongs to the ferritin family. ferroxidase activity iron ion binding extracellular region cytoplasm mitochondrion iron ion transport cellular iron ion homeostasis intracellular sequestering of iron ion immune response ferrous iron binding ferric iron binding negative regulation of cell proliferation oxidoreductase activity identical protein binding autolysosome metal ion binding negative regulation of fibroblast proliferation oxidation-reduction process endocytic vesicle lumen uc294efn.1 uc294efn.2 
ENSMUST00000235212.3 Gm50229 ENSMUST00000235212.3 Gm50229 (from geneSymbol) ENSMUST00000235212.1 ENSMUST00000235212.2 uc294egd.1 uc294egd.2 uc294egd.3 uc294egd.1 uc294egd.2 uc294egd.3 
ENSMUST00000235226.2 Gm50138 ENSMUST00000235226.2 Gm50138 (from geneSymbol) ENSMUST00000235226.1 uc294egr.1 uc294egr.2 uc294egr.1 uc294egr.2 
ENSMUST00000235246.2 Gm50276 ENSMUST00000235246.2 Gm50276 (from geneSymbol) ENSMUST00000235246.1 uc294ehl.1 uc294ehl.2 uc294ehl.1 uc294ehl.2 
ENSMUST00000235247.2 Gm50316 ENSMUST00000235247.2 Gm50316 (from geneSymbol) ENSMUST00000235247.1 uc294ehm.1 uc294ehm.2 uc294ehm.1 uc294ehm.2 
ENSMUST00000235250.2 Gm50287 ENSMUST00000235250.2 Gm50287 (from geneSymbol) AK042311 ENSMUST00000235250.1 uc294ehp.1 uc294ehp.2 uc294ehp.1 uc294ehp.2 
ENSMUST00000235251.3 Gm4230 ENSMUST00000235251.3 predicted gene 4230 (from RefSeq NR_188854.1) ENSMUST00000235251.1 ENSMUST00000235251.2 NR_188854 uc294ehq.1 uc294ehq.2 uc294ehq.3 uc294ehq.1 uc294ehq.2 uc294ehq.3 
ENSMUST00000235253.2 Gm34299 ENSMUST00000235253.2 Gm34299 (from geneSymbol) AK077353 ENSMUST00000235253.1 uc294ehs.1 uc294ehs.2 uc294ehs.1 uc294ehs.2 
ENSMUST00000235256.2 Lncbate10 ENSMUST00000235256.2 brown adipose tissue enriched long noncoding RNA 10 (from RefSeq NR_045419.1) ENSMUST00000235256.1 NR_045419 uc294ehv.1 uc294ehv.2 uc294ehv.1 uc294ehv.2 
ENSMUST00000235262.2 Gm50362 ENSMUST00000235262.2 Gm50362 (from geneSymbol) ENSMUST00000235262.1 uc294eib.1 uc294eib.2 uc294eib.1 uc294eib.2 
ENSMUST00000235286.2 F730048M01Rik ENSMUST00000235286.2 F730048M01Rik (from geneSymbol) AK089536 ENSMUST00000235286.1 uc294eiz.1 uc294eiz.2 uc294eiz.1 uc294eiz.2 
ENSMUST00000235289.2 A930001C03Rik ENSMUST00000235289.2 RIKEN cDNA A930001C03 gene, transcript variant 2 (from RefSeq NR_045990.1) ENSMUST00000235289.1 NR_045990 uc294ejc.1 uc294ejc.2 uc294ejc.1 uc294ejc.2 
ENSMUST00000235291.2 Gm50338 ENSMUST00000235291.2 Gm50338 (from geneSymbol) ENSMUST00000235291.1 uc294eje.1 uc294eje.2 uc294eje.1 uc294eje.2 
ENSMUST00000235292.2 Gm50318 ENSMUST00000235292.2 Gm50318 (from geneSymbol) A0A494B9A8 A0A494B9A8_MOUSE BC064044 ENSMUST00000235292.1 Gm50318 uc294ejf.1 uc294ejf.2 uc294ejf.1 uc294ejf.2 
ENSMUST00000235304.3 Gm29966 ENSMUST00000235304.3 Gm29966 (from geneSymbol) ENSMUST00000235304.1 ENSMUST00000235304.2 uc294ejr.1 uc294ejr.2 uc294ejr.3 uc294ejr.1 uc294ejr.2 uc294ejr.3 
ENSMUST00000235329.2 Gm50230 ENSMUST00000235329.2 Gm50230 (from geneSymbol) AK169801 ENSMUST00000235329.1 uc294eko.1 uc294eko.2 uc294eko.1 uc294eko.2 
ENSMUST00000235343.2 Nedd4l ENSMUST00000235343.2 neural precursor cell expressed, developmentally down-regulated gene 4-like, transcript variant 1 (from RefSeq NM_001114386.2) A0A494BAG2 A0A494BAG2_MOUSE ENSMUST00000235343.1 NM_001114386 Nedd4l uc294elc.1 uc294elc.2 Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence=; Protein modification; protein ubiquitination. ubiquitin-protein transferase activity ubiquitin-dependent protein catabolic process protein ubiquitination transferase activity ubiquitin protein ligase activity uc294elc.1 uc294elc.2 
ENSMUST00000235344.2 Gm50196 ENSMUST00000235344.2 Gm50196 (from geneSymbol) AK042144 ENSMUST00000235344.1 uc294eld.1 uc294eld.2 uc294eld.1 uc294eld.2 
ENSMUST00000235362.2 Gm31912 ENSMUST00000235362.2 Gm31912 (from geneSymbol) AK047239 ENSMUST00000235362.1 uc294elu.1 uc294elu.2 uc294elu.1 uc294elu.2 
ENSMUST00000235373.3 Gm50285 ENSMUST00000235373.3 Gm50285 (from geneSymbol) AK132587 ENSMUST00000235373.1 ENSMUST00000235373.2 uc294emf.1 uc294emf.2 uc294emf.3 uc294emf.1 uc294emf.2 uc294emf.3 
ENSMUST00000235377.2 Gm50210 ENSMUST00000235377.2 Gm50210 (from geneSymbol) ENSMUST00000235377.1 uc294emj.1 uc294emj.2 uc294emj.1 uc294emj.2 
ENSMUST00000235397.2 Gm50455 ENSMUST00000235397.2 Gm50455 (from geneSymbol) ENSMUST00000235397.1 uc294ena.1 uc294ena.2 uc294ena.1 uc294ena.2 
ENSMUST00000235402.2 Gm50161 ENSMUST00000235402.2 Gm50161 (from geneSymbol) ENSMUST00000235402.1 uc294enf.1 uc294enf.2 uc294enf.1 uc294enf.2 
ENSMUST00000235410.2 Gm34517 ENSMUST00000235410.2 Gm34517 (from geneSymbol) AK132743 ENSMUST00000235410.1 uc294enn.1 uc294enn.2 uc294enn.1 uc294enn.2 
ENSMUST00000235427.2 Gm50395 ENSMUST00000235427.2 Gm50395 (from geneSymbol) ENSMUST00000235427.1 uc294eoe.1 uc294eoe.2 uc294eoe.1 uc294eoe.2 
ENSMUST00000235435.3 Gm50227 ENSMUST00000235435.3 Gm50227 (from geneSymbol) AK043336 ENSMUST00000235435.1 ENSMUST00000235435.2 uc294eom.1 uc294eom.2 uc294eom.3 uc294eom.1 uc294eom.2 uc294eom.3 
ENSMUST00000235445.2 B020010K11Rik ENSMUST00000235445.2 B020010K11Rik (from geneSymbol) AK139683 ENSMUST00000235445.1 uc294eov.1 uc294eov.2 uc294eov.1 uc294eov.2 
ENSMUST00000235450.2 Tbc1d10c ENSMUST00000235450.2 TBC1 domain family, member 10c (from RefSeq NM_178650.3) ENSMUST00000235450.1 NM_178650 Q3V3L7 Q6KAN0 Q8C2R6 Q8C6F7 Q8C9V1 TB10C_MOUSE uc294epa.1 uc294epa.2 Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras (By similarity). Interacts with both calcineurin and HRAS. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8C9V1-1; Sequence=Displayed; Name=2; IsoId=Q8C9V1-2; Sequence=VSP_024538; Name=3; IsoId=Q8C9V1-3; Sequence=VSP_024536; Name=4; IsoId=Q8C9V1-4; Sequence=VSP_024537, VSP_024539; The arginine and glutamine fingers are critical for the GTPase- activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site. Sequence=BAD21427.1; Type=Erroneous initiation; Evidence=; GTPase activator activity cytosol plasma membrane intracellular protein transport Rab GTPase binding filopodium membrane retrograde transport, endosome to Golgi negative regulation of B cell activation negative regulation of ERK1 and ERK2 cascade negative regulation of calcineurin-NFAT signaling cascade activation of GTPase activity uc294epa.1 uc294epa.2 
ENSMUST00000235451.2 Gm50393 ENSMUST00000235451.2 Gm50393 (from geneSymbol) AK132453 ENSMUST00000235451.1 uc294epb.1 uc294epb.2 uc294epb.1 uc294epb.2 
ENSMUST00000235452.3 Gm50292 ENSMUST00000235452.3 Gm50292 (from geneSymbol) AK046168 ENSMUST00000235452.1 ENSMUST00000235452.2 uc294epc.1 uc294epc.2 uc294epc.3 uc294epc.1 uc294epc.2 uc294epc.3 
ENSMUST00000235466.3 Gm50265 ENSMUST00000235466.3 Gm50265 (from geneSymbol) AK051754 ENSMUST00000235466.1 ENSMUST00000235466.2 uc294epq.1 uc294epq.2 uc294epq.3 uc294epq.1 uc294epq.2 uc294epq.3 
ENSMUST00000235470.3 4931439C15Rik ENSMUST00000235470.3 RIKEN cDNA 4931439C15 gene (from RefSeq NR_167721.1) ENSMUST00000235470.1 ENSMUST00000235470.2 NR_167721 uc294ept.1 uc294ept.2 uc294ept.3 uc294ept.1 uc294ept.2 uc294ept.3 
ENSMUST00000235474.2 Fam246a ENSMUST00000235474.2 Fam246a (from geneSymbol) A0A494B9C2 A0A494B9C2_MOUSE B830017H08Rik ENSMUST00000235474.1 Fam246a uc294epw.1 uc294epw.2 uc294epw.1 uc294epw.2 
ENSMUST00000235475.2 St8sia3os ENSMUST00000235475.2 St8sia3os (from geneSymbol) AK007031 ENSMUST00000235475.1 uc294epx.1 uc294epx.2 uc294epx.1 uc294epx.2 
ENSMUST00000235480.2 Hmgxb3 ENSMUST00000235480.2 HMG box domain containing 3, transcript variant 1 (from RefSeq NM_178277.1) ENSMUST00000235480.1 Hmgxb3 NM_178277 Q6AXF8 Q6AXF8_MOUSE uc294eqc.1 uc294eqc.2 molecular_function DNA binding cellular_component nucleus biological_process uc294eqc.1 uc294eqc.2 
ENSMUST00000235511.2 Gm54639 ENSMUST00000235511.2 Gm54639 (from geneSymbol) ENSMUST00000235511.1 LF201741 uc294erg.1 uc294erg.2 uc294erg.1 uc294erg.2 
ENSMUST00000235513.2 Gm550 ENSMUST00000235513.2 predicted gene 550 (from RefSeq NM_001362427.1) A0A494BBN4 A0A494BBN4_MOUSE ENSMUST00000235513.1 Gm550 NM_001362427 uc294eri.1 uc294eri.2 uc294eri.1 uc294eri.2 
ENSMUST00000235514.2 Gm10802 ENSMUST00000235514.2 Gm10802 (from geneSymbol) AK155789 ENSMUST00000235514.1 uc294erj.1 uc294erj.2 uc294erj.1 uc294erj.2 
ENSMUST00000235517.2 Gm50251 ENSMUST00000235517.2 Gm50251 (from geneSymbol) ENSMUST00000235517.1 uc294erm.1 uc294erm.2 uc294erm.1 uc294erm.2 
ENSMUST00000235530.2 H2-Eb1 ENSMUST00000235530.2 histocompatibility 2, class II antigen E beta (from RefSeq NM_010382.2) Btnl2 ENSMUST00000235530.1 F6VX29 H2-Eb1 IEbeta NM_010382 O78196 O78196_MOUSE uc294erz.1 uc294erz.2 Membrane ; Single- pass type I membrane protein Belongs to the MHC class II family. adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune response membrane integral component of membrane antigen processing and presentation MHC class II protein complex uc294erz.1 uc294erz.2 
ENSMUST00000235539.2 Gm50142 ENSMUST00000235539.2 Gm50142 (from geneSymbol) ENSMUST00000235539.1 uc294esi.1 uc294esi.2 uc294esi.1 uc294esi.2 
ENSMUST00000235544.2 Gm50232 ENSMUST00000235544.2 Gm50232 (from geneSymbol) ENSMUST00000235544.1 uc294esn.1 uc294esn.2 uc294esn.1 uc294esn.2 
ENSMUST00000235547.2 Glo1 ENSMUST00000235547.2 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:18695250). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). Required for normal osteoclastogenesis (PubMed:18695250). (from UniProt Q9CPU0) AK049703 ENSMUST00000235547.1 LGUL_MOUSE Q543L3 Q8R3T1 Q9CPU0 uc294esq.1 uc294esq.2 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:18695250). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). Required for normal osteoclastogenesis (PubMed:18695250). Reaction=(R)-S-lactoylglutathione = glutathione + methylglyoxal; Xref=Rhea:RHEA:19069, ChEBI:CHEBI:17158, ChEBI:CHEBI:57474, ChEBI:CHEBI:57925; EC=4.4.1.5; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:19071; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits. ; Subject to competitive inhibition by methyl- gerfelin. Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2. Homodimer. Glutathionylation at Cys-139 inhibits enzyme activity. Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B (By similarity). Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B (By similarity). Expressed at higher levels in CD-1 mice which have been bred for low-anxiety-related behavior than in those which have been bred for high-anxiety-related behavior. Belongs to the glyoxalase I family. lactoylglutathione lyase activity nucleus cytosol plasma membrane carbohydrate metabolic process regulation of transcription from RNA polymerase II promoter glutathione metabolic process zinc ion binding methylglyoxal metabolic process lyase activity methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione osteoclast differentiation negative regulation of apoptotic process metal ion binding uc294esq.1 uc294esq.2 
ENSMUST00000235569.2 Tsga10ip ENSMUST00000235569.2 testis specific 10 interacting protein (from RefSeq NM_001373978.1) A0A494BAR6 A0A494BAR6_MOUSE ENSMUST00000235569.1 NM_001373978 Tsga10ip uc294etl.1 uc294etl.2 molecular_function photoreceptor connecting cilium cilium organization ciliary basal body uc294etl.1 uc294etl.2 
ENSMUST00000235574.2 Vmn1r222 ENSMUST00000235574.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R269) ENSMUST00000235574.1 Q8R269 Q8R269_MOUSE V1rh16 Vmn1r222 uc294etq.1 uc294etq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294etq.1 uc294etq.2 
ENSMUST00000235575.2 Ap5b1 ENSMUST00000235575.2 adaptor-related protein complex 5, beta 1 subunit, transcript variant 2 (from RefSeq NM_001362046.1) AP5B1_MOUSE ENSMUST00000235575.1 Gm962 NM_001362046 Q3TAP4 uc294etr.1 uc294etr.2 As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. Probably part of the adaptor protein complex 5 (AP-5), a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Interacts with ZFYVE26 and SPG11 (By similarity). molecular_function protein transport endosomal transport AP-type membrane coat adaptor complex uc294etr.1 uc294etr.2 
ENSMUST00000235588.2 Gm50282 ENSMUST00000235588.2 Gm50282 (from geneSymbol) ENSMUST00000235588.1 uc294eud.1 uc294eud.2 uc294eud.1 uc294eud.2 
ENSMUST00000235589.2 1700054A03Rik ENSMUST00000235589.2 1700054A03Rik (from geneSymbol) AK018858 ENSMUST00000235589.1 uc294eue.1 uc294eue.2 uc294eue.1 uc294eue.2 
ENSMUST00000235594.2 Papss2 ENSMUST00000235594.2 3'-phosphoadenosine 5'-phosphosulfate synthase 2, transcript variant 2 (from RefSeq NM_001201470.1) A0A494B923 A0A494B923_MOUSE ENSMUST00000235594.1 NM_001201470 Papss2 uc294euj.1 uc294euj.2 Sulfur metabolism; sulfate assimilation. In the C-terminal section; belongs to the sulfate adenylyltransferase family. In the N-terminal section; belongs to the APS kinase family. sulfate assimilation adenylylsulfate kinase activity sulfate adenylyltransferase (ATP) activity ATP binding phosphorylation uc294euj.1 uc294euj.2 
ENSMUST00000235597.2 Gm50445 ENSMUST00000235597.2 Gm50445 (from geneSymbol) ENSMUST00000235597.1 uc294eum.1 uc294eum.2 uc294eum.1 uc294eum.2 
ENSMUST00000235606.2 Prelid2 ENSMUST00000235606.2 PRELI domain containing 2 (from RefSeq NM_029942.1) ENSMUST00000235606.1 NM_029942 PRLD2_MOUSE Q0VBB0 Q9CRD8 uc294euv.1 uc294euv.2 mitochondrion mitochondrial intermembrane space phospholipid transport phosphatidic acid transporter activity uc294euv.1 uc294euv.2 
ENSMUST00000235607.3 Gm41804 ENSMUST00000235607.3 Gm41804 (from geneSymbol) ENSMUST00000235607.1 ENSMUST00000235607.2 uc294euw.1 uc294euw.2 uc294euw.3 uc294euw.1 uc294euw.2 uc294euw.3 
ENSMUST00000235608.4 1700086O06Rik ENSMUST00000235608.4 1700086O06Rik (from geneSymbol) AK078369 ENSMUST00000235608.1 ENSMUST00000235608.2 ENSMUST00000235608.3 uc294eux.1 uc294eux.2 uc294eux.3 uc294eux.4 uc294eux.1 uc294eux.2 uc294eux.3 uc294eux.4 
ENSMUST00000235613.2 Gm50132 ENSMUST00000235613.2 Gm50132 (from geneSymbol) ENSMUST00000235613.1 uc294evc.1 uc294evc.2 uc294evc.1 uc294evc.2 
ENSMUST00000235616.3 Gm50329 ENSMUST00000235616.3 Gm50329 (from geneSymbol) ENSMUST00000235616.1 ENSMUST00000235616.2 uc294evf.1 uc294evf.2 uc294evf.3 uc294evf.1 uc294evf.2 uc294evf.3 
ENSMUST00000235621.2 Gm50383 ENSMUST00000235621.2 Gm50383 (from geneSymbol) ENSMUST00000235621.1 uc294evk.1 uc294evk.2 uc294evk.1 uc294evk.2 
ENSMUST00000235628.3 Gm50100 ENSMUST00000235628.3 Gm50100 (from geneSymbol) ENSMUST00000235628.1 ENSMUST00000235628.2 uc294evr.1 uc294evr.2 uc294evr.3 uc294evr.1 uc294evr.2 uc294evr.3 
ENSMUST00000235635.2 Gm50317 ENSMUST00000235635.2 Gm50317 (from geneSymbol) AK149616 ENSMUST00000235635.1 uc294evy.1 uc294evy.2 uc294evy.1 uc294evy.2 
ENSMUST00000235637.4 Gm42064 ENSMUST00000235637.4 Gm42064 (from geneSymbol) ENSMUST00000235637.1 ENSMUST00000235637.2 ENSMUST00000235637.3 uc294ewa.1 uc294ewa.2 uc294ewa.3 uc294ewa.4 uc294ewa.1 uc294ewa.2 uc294ewa.3 uc294ewa.4 
ENSMUST00000235642.2 Gm50417 ENSMUST00000235642.2 Gm50417 (from geneSymbol) ENSMUST00000235642.1 uc294ewf.1 uc294ewf.2 uc294ewf.1 uc294ewf.2 
ENSMUST00000235649.2 Gm54728 ENSMUST00000235649.2 Gm54728 (from geneSymbol) ENSMUST00000235649.1 uc294ewl.1 uc294ewl.2 uc294ewl.1 uc294ewl.2 
ENSMUST00000235655.2 Gm50201 ENSMUST00000235655.2 Gm50201 (from geneSymbol) ENSMUST00000235655.1 uc294ewr.1 uc294ewr.2 uc294ewr.1 uc294ewr.2 
ENSMUST00000235668.2 Gm50403 ENSMUST00000235668.2 Gm50403 (from geneSymbol) ENSMUST00000235668.1 uc294exe.1 uc294exe.2 uc294exe.1 uc294exe.2 
ENSMUST00000235677.2 Gm50410 ENSMUST00000235677.2 Gm50410 (from geneSymbol) ENSMUST00000235677.1 uc294exm.1 uc294exm.2 uc294exm.1 uc294exm.2 
ENSMUST00000235679.2 Snhg4 ENSMUST00000235679.2 small nucleolar RNA host gene 4, transcript variant 4 (from RefSeq NR_182665.1) ENSMUST00000235679.1 NR_182665 uc294exo.1 uc294exo.2 uc294exo.1 uc294exo.2 
ENSMUST00000235695.3 Gm50240 ENSMUST00000235695.3 Gm50240 (from geneSymbol) AK006324 ENSMUST00000235695.1 ENSMUST00000235695.2 uc294eyd.1 uc294eyd.2 uc294eyd.3 uc294eyd.1 uc294eyd.2 uc294eyd.3 
ENSMUST00000235703.3 Gm50441 ENSMUST00000235703.3 Gm50441 (from geneSymbol) ENSMUST00000235703.1 ENSMUST00000235703.2 uc294eyl.1 uc294eyl.2 uc294eyl.3 uc294eyl.1 uc294eyl.2 uc294eyl.3 
ENSMUST00000235723.2 Gm50195 ENSMUST00000235723.2 Gm50195 (from geneSymbol) ENSMUST00000235723.1 uc294ezf.1 uc294ezf.2 uc294ezf.1 uc294ezf.2 
ENSMUST00000235733.2 Gm50331 ENSMUST00000235733.2 Gm50331 (from geneSymbol) ENSMUST00000235733.1 uc294ezp.1 uc294ezp.2 uc294ezp.1 uc294ezp.2 
ENSMUST00000235737.2 Gm50209 ENSMUST00000235737.2 Gm50209 (from geneSymbol) ENSMUST00000235737.1 uc294ezt.1 uc294ezt.2 uc294ezt.1 uc294ezt.2 
ENSMUST00000235753.2 Vmn1r85 ENSMUST00000235753.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8VIB8) ENSMUST00000235753.1 Q8VIB8 Q8VIB8_MOUSE V1RE9 V1rj3 Vmn1r85 uc294fai.1 uc294fai.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294fai.1 uc294fai.2 
ENSMUST00000235789.2 Gm28578 ENSMUST00000235789.2 Gm28578 (from geneSymbol) BC072619 ENSMUST00000235789.1 uc294fbr.1 uc294fbr.2 uc294fbr.1 uc294fbr.2 
ENSMUST00000235804.2 Gm50215 ENSMUST00000235804.2 Gm50215 (from geneSymbol) AK086704 ENSMUST00000235804.1 uc294fcg.1 uc294fcg.2 uc294fcg.1 uc294fcg.2 
ENSMUST00000235809.2 Gm50270 ENSMUST00000235809.2 Gm50270 (from geneSymbol) BC049356 ENSMUST00000235809.1 uc294fcl.1 uc294fcl.2 uc294fcl.1 uc294fcl.2 
ENSMUST00000235810.2 Gm50354 ENSMUST00000235810.2 Gm50354 (from geneSymbol) ENSMUST00000235810.1 uc294fcm.1 uc294fcm.2 uc294fcm.1 uc294fcm.2 
ENSMUST00000235822.2 Zfp532 ENSMUST00000235822.2 May be involved in transcriptional regulation. (from UniProt S4R2I9) BC094671 ENSMUST00000235822.1 S4R2I9 S4R2I9_MOUSE Zfp532 uc294fcy.1 uc294fcy.2 May be involved in transcriptional regulation. Nucleus Belongs to the krueppel C2H2-type zinc-finger protein family. nucleic acid binding uc294fcy.1 uc294fcy.2 
ENSMUST00000235823.2 Gm50137 ENSMUST00000235823.2 Gm50137 (from geneSymbol) ENSMUST00000235823.1 uc294fcz.1 uc294fcz.2 uc294fcz.1 uc294fcz.2 
ENSMUST00000235825.2 Gm50172 ENSMUST00000235825.2 Gm50172 (from geneSymbol) ENSMUST00000235825.1 uc294fdb.1 uc294fdb.2 uc294fdb.1 uc294fdb.2 
ENSMUST00000235838.2 4933403J19Rik ENSMUST00000235838.2 4933403J19Rik (from geneSymbol) ENSMUST00000235838.1 NR_190435 uc294fdo.1 uc294fdo.2 uc294fdo.1 uc294fdo.2 
ENSMUST00000235839.2 Gm50322 ENSMUST00000235839.2 Gm50322 (from geneSymbol) ENSMUST00000235839.1 LF201662 uc294fdp.1 uc294fdp.2 uc294fdp.1 uc294fdp.2 
ENSMUST00000235841.2 Gm26972 ENSMUST00000235841.2 Gm26972 (from geneSymbol) ENSMUST00000235841.1 uc294fdr.1 uc294fdr.2 uc294fdr.1 uc294fdr.2 
ENSMUST00000235858.2 Gm50252 ENSMUST00000235858.2 Gm50252 (from geneSymbol) AK087881 ENSMUST00000235858.1 uc294feh.1 uc294feh.2 uc294feh.1 uc294feh.2 
ENSMUST00000235867.2 Gm31854 ENSMUST00000235867.2 Gm31854 (from geneSymbol) ENSMUST00000235867.1 uc294feo.1 uc294feo.2 uc294feo.1 uc294feo.2 
ENSMUST00000235874.3 1700095A13Rik ENSMUST00000235874.3 1700095A13Rik (from geneSymbol) AK007073 ENSMUST00000235874.1 ENSMUST00000235874.2 uc294fev.1 uc294fev.2 uc294fev.3 uc294fev.1 uc294fev.2 uc294fev.3 
ENSMUST00000235879.2 Gm50273 ENSMUST00000235879.2 Gm50273 (from geneSymbol) AK132438 ENSMUST00000235879.1 uc294fez.1 uc294fez.2 uc294fez.1 uc294fez.2 
ENSMUST00000235886.2 Vmn1r-ps27 ENSMUST00000235886.2 Vmn1r-ps27 (from geneSymbol) ENSMUST00000235886.1 uc294ffg.1 uc294ffg.2 uc294ffg.1 uc294ffg.2 
ENSMUST00000235889.2 Gm50367 ENSMUST00000235889.2 Gm50367 (from geneSymbol) AK146214 ENSMUST00000235889.1 uc294ffj.1 uc294ffj.2 uc294ffj.1 uc294ffj.2 
ENSMUST00000235890.3 Gm9937 ENSMUST00000235890.3 Gm9937 (from geneSymbol) ENSMUST00000235890.1 ENSMUST00000235890.2 LF201005 uc294ffk.1 uc294ffk.2 uc294ffk.3 uc294ffk.1 uc294ffk.2 uc294ffk.3 
ENSMUST00000235895.2 Vmn1r234 ENSMUST00000235895.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R298) ENSMUST00000235895.1 Q8R298 Q8R298_MOUSE V1rf1 Vmn1r234 uc294ffo.1 uc294ffo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294ffo.1 uc294ffo.2 
ENSMUST00000235907.2 Gm56118 ENSMUST00000235907.2 Gm56118 (from geneSymbol) A0A494B9I6 A0A494B9I6_MOUSE ENSMUST00000235907.1 Gm56118 uc294ffz.1 uc294ffz.2 membrane integral component of membrane uc294ffz.1 uc294ffz.2 
ENSMUST00000235909.2 Gm45352 ENSMUST00000235909.2 Gm45352 (from geneSymbol) AK090268 ENSMUST00000235909.1 uc294fgb.1 uc294fgb.2 uc294fgb.1 uc294fgb.2 
ENSMUST00000235911.2 Gm50411 ENSMUST00000235911.2 Gm50411 (from geneSymbol) ENSMUST00000235911.1 uc294fgd.1 uc294fgd.2 uc294fgd.1 uc294fgd.2 
ENSMUST00000235914.2 Gm50405 ENSMUST00000235914.2 Gm50405 (from geneSymbol) ENSMUST00000235914.1 uc294fgg.1 uc294fgg.2 uc294fgg.1 uc294fgg.2 
ENSMUST00000235919.2 Gm50371 ENSMUST00000235919.2 Gm50371 (from geneSymbol) BC003923 ENSMUST00000235919.1 uc294fgl.1 uc294fgl.2 uc294fgl.1 uc294fgl.2 
ENSMUST00000235920.2 Gm53015 ENSMUST00000235920.2 Gm53015 (from geneSymbol) ENSMUST00000235920.1 LF256690 uc294fgm.1 uc294fgm.2 uc294fgm.1 uc294fgm.2 
ENSMUST00000235923.2 Gm50214 ENSMUST00000235923.2 Gm50214 (from geneSymbol) ENSMUST00000235923.1 uc294fgp.1 uc294fgp.2 uc294fgp.1 uc294fgp.2 
ENSMUST00000235927.2 Vps37c ENSMUST00000235927.2 vacuolar protein sorting 37C, transcript variant 8 (from RefSeq NM_001361964.1) ENSMUST00000235927.1 NM_001361964 Q3TY76 Q8R105 VP37C_MOUSE uc294fgt.1 uc294fgt.2 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity). Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with HGS and STAM2. Interacts with CEP55 (By similarity). Late endosome membrane ; Peripheral membrane protein Note=Probably associates with membranes. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8R105-1; Sequence=Displayed; Name=2; IsoId=Q8R105-2; Sequence=VSP_029730; Phosphorylated by TBK1. Belongs to the VPS37 family. ESCRT I complex endosome protein targeting to membrane protein targeting to vacuole protein transport membrane late endosome membrane endosome transport via multivesicular body sorting pathway ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway intracellular membrane-bounded organelle calcium-dependent protein binding uc294fgt.1 uc294fgt.2 
ENSMUST00000235942.4 4833438C02Rik ENSMUST00000235942.4 RIKEN cDNA 4833438C02 gene, transcript variant 1 (from RefSeq NR_152247.1) ENSMUST00000235942.1 ENSMUST00000235942.2 ENSMUST00000235942.3 NR_152247 uc294fhi.1 uc294fhi.2 uc294fhi.3 uc294fhi.4 uc294fhi.1 uc294fhi.2 uc294fhi.3 uc294fhi.4 
ENSMUST00000235957.2 Gpam ENSMUST00000235957.2 glycerol-3-phosphate acyltransferase, mitochondrial, transcript variant 3 (from RefSeq NM_001410454.1) ENSMUST00000235957.1 GPAT1_MOUSE Gpam Gpat1 NM_001410454 Q61586 Q8VCT2 uc294fhw.1 uc294fhw.2 Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids. Reaction=an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3- phosphate + CoA; Xref=Rhea:RHEA:15325, ChEBI:CHEBI:57287, ChEBI:CHEBI:57597, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342; EC=2.3.1.15; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15326; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1- (9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37203, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:57597, ChEBI:CHEBI:74547; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37204; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z- octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37199, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57597, ChEBI:CHEBI:74544; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37200; Evidence=; Reaction=octadecanoyl-CoA + sn-glycerol 3-phosphate = 1-octadecanoyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37195, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57597, ChEBI:CHEBI:74565; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37196; Evidence=; Reaction=hexadecanoyl-CoA + sn-glycerol 3-phosphate = 1-hexadecanoyl- sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:35723, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57518, ChEBI:CHEBI:57597; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35724; Evidence=; Reaction=dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn- glycerol 3-phosphate + CoA; Xref=Rhea:RHEA:35727, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:57597, ChEBI:CHEBI:72682; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35728; Evidence=; Reaction=1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:33203, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64716, ChEBI:CHEBI:64840; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33204; Evidence=; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 1/3. Mitochondrion outer membrane ; Multi-pass membrane protein Highest levels in liver, intermediate levels in muscle and kidney, and lowest levels in lung and brain. The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. Belongs to the GPAT/DAPAT family. glycerol-3-phosphate O-acyltransferase activity mitochondrion mitochondrial outer membrane mitochondrial inner membrane plasma membrane glycerol-3-phosphate metabolic process lipid metabolic process fatty acid metabolic process acyl-CoA metabolic process triglyceride metabolic process glycerophospholipid metabolic process O-acyltransferase activity phospholipid biosynthetic process response to glucose positive regulation of triglyceride biosynthetic process response to activity membrane integral component of membrane CDP-diacylglycerol biosynthetic process transferase activity transferase activity, transferring acyl groups triglyceride biosynthetic process mitochondrial membrane cellular response to insulin stimulus positive regulation of multicellular organism growth positive regulation of activated T cell proliferation cellular lipid metabolic process regulation of cytokine secretion defense response to virus fatty acid homeostasis phospholipid homeostasis negative regulation of activation-induced cell death of T cells interleukin-2 secretion uc294fhw.1 uc294fhw.2 
ENSMUST00000235966.2 Rps14 ENSMUST00000235966.2 Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). (from UniProt P62264) AK028106 ENSMUST00000235966.1 P06366 P62264 Q544W4 RS14_MOUSE uc294fif.1 uc294fif.2 Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Component of the small ribosomal subunit (PubMed:36517592). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Cytoplasm Nucleus, nucleolus Belongs to the universal ribosomal protein uS11 family. ribosomal small subunit assembly negative regulation of transcription from RNA polymerase II promoter maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA binding structural constituent of ribosome nucleolus mitochondrion ribosome translation regulation of translation postsynaptic density cytosolic small ribosomal subunit erythrocyte differentiation maturation of SSU-rRNA translation regulator activity mRNA 5'-UTR binding small ribosomal subunit rRNA binding uc294fif.1 uc294fif.2 
ENSMUST00000235985.2 Gm50312 ENSMUST00000235985.2 Gm50312 (from geneSymbol) ENSMUST00000235985.1 uc294fiy.1 uc294fiy.2 uc294fiy.1 uc294fiy.2 
ENSMUST00000235996.3 Gm50414 ENSMUST00000235996.3 Gm50414 (from geneSymbol) ENSMUST00000235996.1 ENSMUST00000235996.2 uc294fjj.1 uc294fjj.2 uc294fjj.3 uc294fjj.1 uc294fjj.2 uc294fjj.3 
ENSMUST00000235997.2 ENSMUSG00000121830 ENSMUST00000235997.2 ENSMUSG00000121830 (from geneSymbol) AK139675 ENSMUST00000235997.1 uc294fjk.1 uc294fjk.2 uc294fjk.1 uc294fjk.2 
ENSMUST00000236000.2 Gm50107 ENSMUST00000236000.2 Gm50107 (from geneSymbol) ENSMUST00000236000.1 uc294fjn.1 uc294fjn.2 uc294fjn.1 uc294fjn.2 
ENSMUST00000236011.2 Atad1 ENSMUST00000236011.2 Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP- dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (PubMed:21496646). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (PubMed:21496646). (from UniProt Q9D5T0) ATAD1_MOUSE Atad1 BC043051 ENSMUST00000236011.1 Q3U8V2 Q9D5T0 Q9D7A4 uc294fjy.1 uc294fjy.2 Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP- dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (PubMed:21496646). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (PubMed:21496646). Reaction=[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:66168, Rhea:RHEA-COMP:16963, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:90782, ChEBI:CHEBI:456216; Evidence= Interacts with GRIA2 and GRIP1 in an ATP-dependent manner (PubMed:21496646). ATAD1-catalyzed ATP hydrolysis disrupts not only its binding to GRIA2 and GRIP1, but also interaction between GRIP1 and GRIA2, leading to AMPAR complex disassembly (PubMed:21496646). Mitochondrion outer membrane ; Single-pass membrane protein Peroxisome membrane ; Single-pass membrane protein Postsynaptic cell membrane ; Single-pass membrane protein Widely expressed with the highest expression in the brain and testis. In the brain, relatively high expression in hippocampal CA1 pyramidal cells (at protein level). About 80% of the mutant mice die of a seizure- like syndrome between postnatal days 19 and 25; the remaining 20% survive up to 8 weeks of age. No gross abnormalities in tissues analyzed, including heart, lung, spleen, kidney, thymus, liver, intestine, testis, eyes, and muscle. In the CA1 region of the hippocampus, no substantial difference in the dendritic complexity or in the number or size of dendritic spines and normal density of synapses in mutant animals compared to wild-type. Belongs to the AAA ATPase family. MSP1 subfamily. nucleotide binding positive regulation of receptor internalization protein binding ATP binding mitochondrion peroxisome plasma membrane learning memory membrane hydrolase activity ATPase activity cell junction synapse postsynaptic membrane negative regulation of synaptic transmission, glutamatergic postsynapse glutamatergic synapse uc294fjy.1 uc294fjy.2 
ENSMUST00000236022.2 ENSMUSG00000121335 ENSMUST00000236022.2 ENSMUSG00000121335 (from geneSymbol) ENSMUST00000236022.1 uc294fkj.1 uc294fkj.2 uc294fkj.1 uc294fkj.2 
ENSMUST00000236043.3 Gm50194 ENSMUST00000236043.3 Gm50194 (from geneSymbol) ENSMUST00000236043.1 ENSMUST00000236043.2 uc294flc.1 uc294flc.2 uc294flc.3 uc294flc.1 uc294flc.2 uc294flc.3 
ENSMUST00000236044.2 Cep55 ENSMUST00000236044.2 centrosomal protein 55, transcript variant 4 (from RefSeq NM_001360663.1) CEP55_MOUSE Cep55 ENSMUST00000236044.1 NM_001360663 Q8BT07 Q8C2J0 Q8K2I8 Q8R2Y4 Q9DBZ8 uc294fld.1 uc294fld.2 Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney. Homodimer. Interacts (phosphorylated on Ser-423 and Ser-426) with PLK1. Interacts with AKAP9/CG-NAP; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT/Kendrin; the interaction occurs in interphase and is lost upon mitotic entry. Directly interacts with PDCD6IP; this interaction is required for PDCD6IP targeting to the midbody; CEP55 binds PDCD6IP in a 2:1 stoichiometry; PDCD6IP competes with TSG101 for the same binding site. Interacts with TSG101; TSG101 competes with PDCD6IP for the same binding site; interaction is required for cytokinesis. Interacts with MVB12A, VPS37B, VPS37C and VPS28 (By similarity). Q8BT07; Q7M6U3: Tex14; NbExp=11; IntAct=EBI-2552328, EBI-6674575; Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cleavage furrow Midbody, Midbody ring Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loses affinity for the centrosome at the onset of prophase and diffuses throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BT07-1; Sequence=Displayed; Name=2; IsoId=Q8BT07-2; Sequence=VSP_018630; There is a hierachy of phosphorylation, where both Ser-423 and Ser-426 are phosphorylated at the onset of mitosis, prior to Ser-434. Phosphorylation at Ser-423 and Ser-426 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-423, Ser-426 and Ser-434, is required for protein function at the final stages of cell division to complete cytokinesis successfully (By similarity). mitotic cytokinesis protein binding cytoplasm centrosome centriole microtubule organizing center cytoskeleton plasma membrane cell cycle regulation of phosphatidylinositol 3-kinase signaling midbody cleavage furrow intercellular bridge establishment of protein localization cell division renal system development Flemming body cranial skeletal system development uc294fld.1 uc294fld.2 
ENSMUST00000236058.2 Xpnpep1 ENSMUST00000236058.2 Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg- Pro-Pro. Contributes to the degradation of bradykinin. (from UniProt Q6P1B1) AK149676 ENSMUST00000236058.1 Q6P1B1 Q91Y37 XPP1_MOUSE Xpnpep1 uc294flr.1 uc294flr.2 Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg- Pro-Pro. Contributes to the degradation of bradykinin. Reaction=Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.; EC=3.4.11.9; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 manganese ions per subunit. ; Homodimer. Cytoplasm, cytosol Belongs to the peptidase M24B family. aminopeptidase activity cytoplasm cytosol proteolysis peptidase activity metallopeptidase activity bradykinin catabolic process hydrolase activity manganese ion binding protein homodimerization activity metal ion binding metalloaminopeptidase activity uc294flr.1 uc294flr.2 
ENSMUST00000236069.2 Gm50236 ENSMUST00000236069.2 Gm50236 (from geneSymbol) ENSMUST00000236069.1 uc294fmc.1 uc294fmc.2 uc294fmc.1 uc294fmc.2 
ENSMUST00000236074.3 Gm50314 ENSMUST00000236074.3 Gm50314 (from geneSymbol) ENSMUST00000236074.1 ENSMUST00000236074.2 uc294fmh.1 uc294fmh.2 uc294fmh.3 uc294fmh.1 uc294fmh.2 uc294fmh.3 
ENSMUST00000236079.2 Gm50165 ENSMUST00000236079.2 Gm50165 (from geneSymbol) DQ714324 ENSMUST00000236079.1 uc294fmm.1 uc294fmm.2 uc294fmm.1 uc294fmm.2 
ENSMUST00000236085.2 Ndfip1 ENSMUST00000236085.2 Nedd4 family interacting protein 1, transcript variant 2 (from RefSeq NM_022996.2) ENSMUST00000236085.1 N4wbp5 NFIP1_MOUSE NM_022996 Q8R0W6 Q9EQH8 uc294fms.1 uc294fms.2 Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation (PubMed:11748237, PubMed:17137798, PubMed:20962770). Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion (PubMed:26319551). Restricts the production of pro-inflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination and degradation of RORC (PubMed:28051111). Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (PubMed:27088444). Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells (PubMed:24520172, PubMed:28051111). Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS (By similarity). Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation (By similarity). In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity (By similarity). Important for normal development of dendrites and dendritic spines in cortex (PubMed:23897647). Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046). Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH (PubMed:25632008). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (By similarity). Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity (PubMed:25801959). Forms heterodimers with NDFIP2 (By similarity). Interacts with several E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L and WWP2 (PubMed:11042109, PubMed:11748237, PubMed:17137798, PubMed:25632008). The interaction with NEDD4, NEDD4L and ITCH leads to relocalization of these proteins to exosomes and eventually to exosomal secretion (PubMed:11748237). Interacts with U2SURP (PubMed:11748237). Interacts with SLC11A2/DMT1 (By similarity). Interacts with PTEN (By similarity). May interact with phosphorylated EGFR (By similarity). Interacts with BRAT1 (By similarity). Interacts with KCNH2 (By similarity). Interacts with MAVS (By similarity). Part of a complex containing ITCH, NDFIP1 and MAP3K7 (PubMed:25632008). Interacts (via N- terminus) with UBE2L3; the interaction mediates recruitment of UBE2L3 to ITCH (PubMed:25632008). Q8R0W6; P46935: Nedd4; NbExp=5; IntAct=EBI-6304119, EBI-773516; Endosome membrane ; Multi-pass membrane protein Golgi apparatus membrane napse, synaptosome Cell projection, dendrite Secreted Note=Detected in exosomes and secreted via the exosomal pathway. Highly expressed in embryonic and early postnatal cortex (at protein level) (PubMed:23897647). Widely expressed (PubMed:11748237). Hardly detectable in resting T-cells; up-regulated in T-cells in response to activation (PubMed:17137798). Up-regulated after traumatic brain injury in surviving neurons around the lesion site. The PPxY motifs are required for E3 ubiquitin-protein ligase binding and activation and for ubiquitination. Ubiquitinated by NEDD4; mono-, di- and polyubiquitinated forms are detected. Ubiquitination regulates its degradation. Undergoes transient tyrosine phosphorylation following EGF stimulation, most probably by catalyzed by SRC. Phosphorylation SRC is enhanced in the presence of NDFIP2 which may act as a scaffold to recruit SRC to NDFIP1 (By similarity). Mutant mice appear normal at birth, but develop severe skin and gastrointestinal tract inflammation around 6 to 8 weeks of age (PubMed:17137798, PubMed:20962770). They do not survive beyond 14 weeks (PubMed:17137798). This phenotype is due to the lack of activity of ITCH E3 ubiquitin-protein ligase, and consequently, prolongation of JUNB half-life after T-cell activation (PubMed:17137798, PubMed:20962770). This results in an increased production of T-helper 2 (Th2) cytokines and in the promotion of Th2- mediated inflammation (PubMed:17137798, PubMed:20962770). This subsequently leads to increased number of circulating, esophagus and small bowel eosinophils (PubMed:20962770). Mutant mice have thicker small bowel and do not gain as much weight as the wild type (PubMed:20962770). Mutant mice also show an increased iron transport in hepatocytes and iron accumulation in the liver around portal veins, in the villi of duodenum and throughout the brain cortex (PubMed:18776082, PubMed:19706893). Sequence=AAG44248.1; Type=Erroneous initiation; Evidence=; Golgi membrane regulation of myeloid leukocyte differentiation negative regulation of type 2 immune response protein binding extracellular region endosome endoplasmic reticulum Golgi apparatus cell cortex ubiquitin-dependent protein catabolic process cellular iron ion homeostasis vacuolar transport endosome membrane negative regulation of gene expression membrane integral component of membrane metal ion transport cell junction integral component of Golgi membrane dendrite positive regulation of protein ubiquitination negative regulation of transporter activity negative regulation of interleukin-4 production negative regulation of T cell proliferation cell projection neuron projection synapse regulation of lymphocyte differentiation positive regulation of protein catabolic process negative regulation of isotype switching to IgE isotypes regulation of isotype switching to IgG isotypes perinuclear region of cytoplasm WW domain binding negative regulation of inflammatory response negative regulation of protein transport uc294fms.1 uc294fms.2 
ENSMUST00000236086.4 Gm41717 ENSMUST00000236086.4 predicted gene, 41717 (from RefSeq NR_166742.1) ENSMUST00000236086.1 ENSMUST00000236086.2 ENSMUST00000236086.3 NR_166742 uc294fmt.1 uc294fmt.2 uc294fmt.3 uc294fmt.4 uc294fmt.1 uc294fmt.2 uc294fmt.3 uc294fmt.4 
ENSMUST00000236092.2 2900057B20Rik ENSMUST00000236092.2 RIKEN cDNA 2900057B20 gene (from RefSeq NR_045365.1) ENSMUST00000236092.1 NR_045365 uc294fmz.1 uc294fmz.2 uc294fmz.1 uc294fmz.2 
ENSMUST00000236095.2 Gm50245 ENSMUST00000236095.2 Gm50245 (from geneSymbol) ENSMUST00000236095.1 uc294fnb.1 uc294fnb.2 uc294fnb.1 uc294fnb.2 
ENSMUST00000236104.3 Gm30381 ENSMUST00000236104.3 predicted gene, 30381 (from RefSeq NR_166769.1) ENSMUST00000236104.1 ENSMUST00000236104.2 NR_166769 uc294fnk.1 uc294fnk.2 uc294fnk.3 uc294fnk.1 uc294fnk.2 uc294fnk.3 
ENSMUST00000236106.2 Gm31265 ENSMUST00000236106.2 Gm31265 (from geneSymbol) ENSMUST00000236106.1 uc294fnm.1 uc294fnm.2 uc294fnm.1 uc294fnm.2 
ENSMUST00000236119.2 Gm50146 ENSMUST00000236119.2 Gm50146 (from geneSymbol) ENSMUST00000236119.1 uc294fnz.1 uc294fnz.2 uc294fnz.1 uc294fnz.2 
ENSMUST00000236124.2 Slc4a9 ENSMUST00000236124.2 solute carrier family 4, sodium bicarbonate cotransporter, member 9, transcript variant 1 (from RefSeq NM_001271544.1) A0A494BA31 AE4 B3A4_MOUSE ENSMUST00000236124.1 NM_001271544 Slc4a9 uc294foe.1 uc294foe.2 Electroneutral Cl(-)/HCO3(-) antiporter that favors chloride ion entry and efflux of hydrogencarbonate and sodium ion across the basolateral membrane and may participate in salivary secretion (PubMed:25745107, PubMed:27114614). Also mediates Cl(-)/HCO3(-) exchange activity in the presence of K(+) as well as Cs(+), Li(+), and Rb(+) (PubMed:27114614). Does not contribute to Cl(-)/HCO3(-) exchanger in the apical membrane of the upper villous epithelium (PubMed:17170027). Reaction=chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) = chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in); Xref=Rhea:RHEA:72739, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101; Evidence= Reaction=chloride(out) + 2 hydrogencarbonate(in) + K(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + K(+)(out); Xref=Rhea:RHEA:75059, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103; Evidence=; Reaction=chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out); Xref=Rhea:RHEA:75063, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996, ChEBI:CHEBI:49713; Evidence=; Reaction=chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out); Xref=Rhea:RHEA:75067, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996, ChEBI:CHEBI:49847; Evidence=; Reaction=chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in) = chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out); Xref=Rhea:RHEA:75071, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996, ChEBI:CHEBI:49547; Evidence=; Cl(-)/HCO3(-) exchanger activity is substantially increased in response to 5 uM isoproterenol (PubMed:34585968). Cl(-)/HCO3(-) exchanger activity is increased by both forskolin and coexpression with the catalytic subunit alpha of PKA (PubMed:34585968). Basolateral cell membrane ulti-pass membrane protein Note=Localized in the basolateral membrane of the cortical collecting duct (CCD)and submandibular gland (SMG) duct. Expressed in submandibular gland (SMG) duct and cortical collecting duct (CCD) of kidney (PubMed:12225984, PubMed:23610411). Lower expressed in duodenal villi (PubMed:17170027). Homozygous mice lacking the Slc4a9 gene have no obvious phenotypical abnormalities. Belongs to the anion exchanger (TC 2.A.31) family. Chambrey et al. shows that the transport mechanism differs in renal cells and suggests that SLC4A9 is a Na(+)/HCO3(-) cotransporter in mouse kidney beta-intercalated cells (PubMed:23610411). However the stoichiometry is not defined and the role of chloride ions is not clear. inorganic anion exchanger activity ion transport anion transport anion transmembrane transporter activity sodium:bicarbonate symporter activity anion:anion antiporter activity inorganic anion transport bicarbonate transport membrane integral component of membrane basolateral plasma membrane apical part of cell regulation of intracellular pH anion transmembrane transport uc294foe.1 uc294foe.2 
ENSMUST00000236133.2 Gm35867 ENSMUST00000236133.2 Gm35867 (from geneSymbol) ENSMUST00000236133.1 uc294fon.1 uc294fon.2 uc294fon.1 uc294fon.2 
ENSMUST00000236135.2 Apcdd1 ENSMUST00000236135.2 adenomatosis polyposis coli down-regulated 1 (from RefSeq NM_133237.4) APCD1_MOUSE Apcdd1 B2RUN4 Drapc1 ENSMUST00000236135.1 NM_133237 Q3TA99 Q3U128 uc294fop.1 uc294fop.2 Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity). Homodimer. Interacts with LRP5 and WNT3A (By similarity). Cell membrane ; Single-pass type I membrane protein Expressed during early development of the extraembryonic structures, nervous system, vascular system and inner ear. Also expressed in mesenchyme of various parts of the embryo and in adult hair follicles. APCDD1 is transcriptionally regulated by the CTNNB1/TF7L2 complex. N-Glycosylated. Belongs to the APCDD1 family. Sequence=BAE42770.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence=; hair follicle development plasma membrane integral component of plasma membrane membrane integral component of membrane Wnt signaling pathway Wnt-protein binding negative regulation of Wnt signaling pathway identical protein binding astrocyte cell migration uc294fop.1 uc294fop.2 
ENSMUST00000236136.2 D730002M21Rik ENSMUST00000236136.2 D730002M21Rik (from geneSymbol) AK142601 ENSMUST00000236136.1 uc294foq.1 uc294foq.2 uc294foq.1 uc294foq.2 
ENSMUST00000236139.2 Gcnt1 ENSMUST00000236139.2 glucosaminyl (N-acetyl) transferase 1, core 2, transcript variant 3 (from RefSeq NM_010265.5) ENSMUST00000236139.1 GCNT1_MOUSE NM_010265 O35981 Q09324 Q8BRB2 uc294fot.1 uc294fot.2 Glycosyltransferase that catalyzes the transfer of an N- acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. The catalysis is metal ion-independent and occurs with inversion of the anomeric configuration of sugar donor (PubMed:9881978, PubMed:12954635, PubMed:22056345). Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites (PubMed:9881978). Can also act on glycolipid substrates. Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage- specific embryonic antigen 1 (SSEA-1) determinant (PubMed:7983056). Can use Galbeta1-3GalNAcalpha1-R and Galbeta1-3GalNAcbeta1-R oligosaccharide derivatives as acceptor substrates (PubMed:7983056). Reaction=O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl- (1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:56212, Rhea:RHEA-COMP:13922, Rhea:RHEA- COMP:14419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:137949, ChEBI:CHEBI:139605; EC=2.4.1.102; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56213; Evidence= Reaction=O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D- glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D- glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl- [protein] + H(+) + UDP; Xref=Rhea:RHEA:56216, Rhea:RHEA-COMP:13923, Rhea:RHEA-COMP:14420, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:137950, ChEBI:CHEBI:139607; EC=2.4.1.102; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56217; Evidence= Reaction=a globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine = a globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP; Xref=Rhea:RHEA:56900, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:140691, ChEBI:CHEBI:140702; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56901; Evidence=; Reaction=a ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine = a ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP; Xref=Rhea:RHEA:69691, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:88069, ChEBI:CHEBI:187897; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69692; Evidence=; Inactivated by thiol-reactive agents. Inhibited by free UDP. Kinetic parameters: KM=1.1 mM for UDP-N-acetyl-alpha-D-glucosamine ; KM=0.11 mM for Beta-D-galactosyl-(1->3)-N-acetyl-alpha-D- galactosaminyl-R ; KM=0.11 mM for Globoside GalGb4Cer ; KM=0.31 mM for Ganglioside GA1 ; KM=1.25 mM for and Galbeta1-3GalNAcalpha1-R ; KM=0.53 mM for Galbeta1-3GalNAcbeta1-R ; Vmax=9.2 umol/min/mg enzyme toward beta-D-galactosyl-(1->3)-N-acetyl- alpha-D-galactosaminyl-R ; Protein modification; protein glycosylation. Glycolipid biosynthesis. Interacts with GOLPH3; may control GCNT1 retention in the Golgi. Golgi apparatus membrane ; Single-pass type II membrane protein Note=Also detected in the trans-Golgi network. Expressed in kidney, liver, stomach, spleen, lung and brain. N-glycosylated. Deficient mice show normal organogenesis and fertility. The loss of core 2 O-glycans on leukocytes is associated with leukocytosis and impaired neutrophil recruitment at the inflammatory site, while lymphocyte homing to peripheral lymphoid organs is not affected. Belongs to the glycosyltransferase 14 family. Name=Functional Glycomics Gateway - GTase; Note=core 2 beta 6 GlcNAc T1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_574"; Golgi membrane beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity extracellular space Golgi apparatus trans-Golgi network protein glycosylation acetylglucosaminyltransferase activity glycoprotein biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups Golgi cisterna response to insulin tissue morphogenesis leukocyte tethering or rolling cell adhesion molecule production kidney morphogenesis uc294fot.1 uc294fot.2 
ENSMUST00000236142.2 Gm50384 ENSMUST00000236142.2 Gm50384 (from geneSymbol) AK142107 ENSMUST00000236142.1 uc294fow.1 uc294fow.2 uc294fow.1 uc294fow.2 
ENSMUST00000236143.2 4930546C10Rik ENSMUST00000236143.2 RIKEN cDNA 4930546C10 gene (from RefSeq NR_038051.1) ENSMUST00000236143.1 NR_038051 uc294fox.1 uc294fox.2 uc294fox.1 uc294fox.2 
ENSMUST00000236145.2 Gm50222 ENSMUST00000236145.2 Gm50222 (from geneSymbol) ENSMUST00000236145.1 uc294foz.1 uc294foz.2 uc294foz.1 uc294foz.2 
ENSMUST00000236152.2 Slc29a2 ENSMUST00000236152.2 solute carrier family 29 (nucleoside transporters), member 2 (from RefSeq NM_007854.3) Der12 ENSMUST00000236152.1 Ent2 Hnp36 NM_007854 Q61672 Q9JIT8 S29A2_MOUSE Slc29a2 uc294fpg.1 uc294fpg.2 Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:11085929). Functions as a Na(+)-independent, passive transporter (By similarity). Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine (PubMed:11085929). Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (By similarity). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites (By similarity). Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier (By similarity). Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production (By similarity). Reaction=inosine(in) = inosine(out); Xref=Rhea:RHEA:75375, ChEBI:CHEBI:17596; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75376; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:75377; Evidence=; Reaction=adenosine(in) = adenosine(out); Xref=Rhea:RHEA:75343, ChEBI:CHEBI:16335; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75344; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:75345; Evidence=; Reaction=uridine(out) = uridine(in); Xref=Rhea:RHEA:71519, ChEBI:CHEBI:16704; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71520; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71521; Evidence=; Reaction=thymidine(in) = thymidine(out); Xref=Rhea:RHEA:75363, ChEBI:CHEBI:17748; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75364; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:75365; Evidence=; Reaction=hypoxanthine(out) = hypoxanthine(in); Xref=Rhea:RHEA:71515, ChEBI:CHEBI:17368; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71516; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71517; Evidence=; Reaction=adenine(out) = adenine(in); Xref=Rhea:RHEA:71523, ChEBI:CHEBI:16708; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71524; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71525; Evidence=; Reaction=cytidine(in) = cytidine(out); Xref=Rhea:RHEA:75367, ChEBI:CHEBI:17562; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75368; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:75369; Evidence=; Reaction=thymine(out) = thymine(in); Xref=Rhea:RHEA:71527, ChEBI:CHEBI:17821; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71528; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71529; Evidence=; Reaction=uracil(in) = uracil(out); Xref=Rhea:RHEA:69404, ChEBI:CHEBI:17568; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69405; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:69406; Evidence=; Reaction=guanine(out) = guanine(in); Xref=Rhea:RHEA:71531, ChEBI:CHEBI:16235; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71532; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71533; Evidence=; Reaction=guanosine(in) = guanosine(out); Xref=Rhea:RHEA:75371, ChEBI:CHEBI:16750; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75372; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:75373; Evidence=; Apical cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Nucleus membrane ; Multi- pass membrane protein By platelet derived growth factor (PDGF) and fibroblast growth factor (FGF). Transport activity is insensitive to nanomolar concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR). Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. Sequence=CAA60381.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; nucleoside transmembrane transporter activity nucleus plasma membrane integral component of plasma membrane adenine transport guanine transport nucleoside transport uridine transport membrane integral component of membrane basolateral plasma membrane nuclear membrane hypoxanthine transport thymine transport presynapse neurotransmitter reuptake nucleoside transmembrane transport uc294fpg.1 uc294fpg.2 
ENSMUST00000236162.2 V1rd19 ENSMUST00000236162.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q3KNP5) ENSMUST00000236162.1 Q3KNP5 Q3KNP5_MOUSE V1rd18 V1rd19 uc294fpo.1 uc294fpo.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane pheromone receptor activity response to pheromone uc294fpo.1 uc294fpo.2 
ENSMUST00000236169.2 Gm50293 ENSMUST00000236169.2 Gm50293 (from geneSymbol) ENSMUST00000236169.1 uc294fpv.1 uc294fpv.2 uc294fpv.1 uc294fpv.2 
ENSMUST00000236177.2 Vmn1r221 ENSMUST00000236177.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A494B935) A0A494B935 A0A494B935_MOUSE ENSMUST00000236177.1 Vmn1r221 uc294fqc.1 uc294fqc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. molecular_function G-protein coupled receptor activity cellular_component plasma membrane signal transduction G-protein coupled receptor signaling pathway biological_process membrane integral component of membrane pheromone receptor activity response to pheromone uc294fqc.1 uc294fqc.2 
ENSMUST00000236179.2 Gm50143 ENSMUST00000236179.2 Gm50143 (from geneSymbol) AK140506 ENSMUST00000236179.1 uc294fqe.1 uc294fqe.2 uc294fqe.1 uc294fqe.2 
ENSMUST00000236198.2 Gm41764 ENSMUST00000236198.2 Gm41764 (from geneSymbol) AK078684 ENSMUST00000236198.1 uc294fqw.1 uc294fqw.2 uc294fqw.1 uc294fqw.2 
ENSMUST00000236200.3 Gm50373 ENSMUST00000236200.3 Gm50373 (from geneSymbol) ENSMUST00000236200.1 ENSMUST00000236200.2 uc294fqy.1 uc294fqy.2 uc294fqy.3 uc294fqy.1 uc294fqy.2 uc294fqy.3 
ENSMUST00000236210.3 4933401L05Rik ENSMUST00000236210.3 4933401L05Rik (from geneSymbol) AK016606 ENSMUST00000236210.1 ENSMUST00000236210.2 uc294fri.1 uc294fri.2 uc294fri.3 uc294fri.1 uc294fri.2 uc294fri.3 
ENSMUST00000236214.3 Gm41815 ENSMUST00000236214.3 Gm41815 (from geneSymbol) ENSMUST00000236214.1 ENSMUST00000236214.2 uc294frm.1 uc294frm.2 uc294frm.3 uc294frm.1 uc294frm.2 uc294frm.3 
ENSMUST00000236216.2 Pggt1b ENSMUST00000236216.2 protein geranylgeranyltransferase type I, beta subunit, transcript variant 9 (from RefSeq NR_184583.1) ENSMUST00000236216.1 NR_184583 PGTB1_MOUSE Q8BUY9 uc294fro.1 uc294fro.2 Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B (By similarity). Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537, ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533, ChEBI:CHEBI:86021; EC=2.5.1.59; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides (By similarity). Belongs to the protein prenyltransferase subunit beta family. catalytic activity prenyltransferase activity protein geranylgeranyltransferase activity CAAX-protein geranylgeranyltransferase activity CAAX-protein geranylgeranyltransferase complex zinc ion binding positive regulation of cell proliferation transferase activity protein prenylation protein geranylgeranylation response to cytokine positive regulation of cell cycle metal ion binding negative regulation of nitric-oxide synthase biosynthetic process drug binding isoprenoid binding peptide binding uc294fro.1 uc294fro.2 
ENSMUST00000236225.2 Gm2176 ENSMUST00000236225.2 predicted gene 2176 (from RefSeq NR_028424.1) ENSMUST00000236225.1 NR_028424 uc294frw.1 uc294frw.2 uc294frw.1 uc294frw.2 
ENSMUST00000236242.2 Vmn1r-ps140 ENSMUST00000236242.2 Vmn1r-ps140 (from geneSymbol) ENSMUST00000236242.1 uc294fsm.1 uc294fsm.2 uc294fsm.1 uc294fsm.2 
ENSMUST00000236243.2 Gm31908 ENSMUST00000236243.2 predicted gene, 31908 (from RefSeq NR_168034.1) ENSMUST00000236243.1 NR_168034 uc294fsn.1 uc294fsn.2 uc294fsn.1 uc294fsn.2 
ENSMUST00000236246.2 Vmn1r68 ENSMUST00000236246.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q0V3) E9Q0V3 E9Q0V3_MOUSE ENSMUST00000236246.1 Vmn1r68 uc294fsq.1 uc294fsq.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294fsq.1 uc294fsq.2 
ENSMUST00000236262.2 Vmn1r60 ENSMUST00000236262.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A494BA35) A0A494BA35 A0A494BA35_MOUSE ENSMUST00000236262.1 Vmn1r60 uc294ftf.1 uc294ftf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294ftf.1 uc294ftf.2 
ENSMUST00000236272.2 Gm50277 ENSMUST00000236272.2 Gm50277 (from geneSymbol) ENSMUST00000236272.1 uc294ftp.1 uc294ftp.2 uc294ftp.1 uc294ftp.2 
ENSMUST00000236274.2 Gm50249 ENSMUST00000236274.2 Gm50249 (from geneSymbol) AK138322 ENSMUST00000236274.1 uc294ftr.1 uc294ftr.2 uc294ftr.1 uc294ftr.2 
ENSMUST00000236285.3 2210409D07Rik ENSMUST00000236285.3 RIKEN cDNA 2210409D07 gene (from RefSeq NR_045360.1) ENSMUST00000236285.1 ENSMUST00000236285.2 NR_045360 uc294fuc.1 uc294fuc.2 uc294fuc.3 uc294fuc.1 uc294fuc.2 uc294fuc.3 
ENSMUST00000236294.2 ENSMUSG00000121679 ENSMUST00000236294.2 ENSMUSG00000121679 (from geneSymbol) AK007267 ENSMUST00000236294.1 uc294fuk.1 uc294fuk.2 uc294fuk.1 uc294fuk.2 
ENSMUST00000236295.2 Gm41793 ENSMUST00000236295.2 Gm41793 (from geneSymbol) ENSMUST00000236295.1 uc294ful.1 uc294ful.2 uc294ful.1 uc294ful.2 
ENSMUST00000236317.2 Gm50377 ENSMUST00000236317.2 Gm50377 (from geneSymbol) ENSMUST00000236317.1 uc294fvf.1 uc294fvf.2 uc294fvf.1 uc294fvf.2 
ENSMUST00000236337.3 4930524O05Rik ENSMUST00000236337.3 4930524O05Rik (from geneSymbol) AK015890 ENSMUST00000236337.1 ENSMUST00000236337.2 uc294fvy.1 uc294fvy.2 uc294fvy.3 uc294fvy.1 uc294fvy.2 uc294fvy.3 
ENSMUST00000236341.2 Gm41821 ENSMUST00000236341.2 Gm41821 (from geneSymbol) ENSMUST00000236341.1 uc294fwc.1 uc294fwc.2 uc294fwc.1 uc294fwc.2 
ENSMUST00000236350.2 Gm50117 ENSMUST00000236350.2 Gm50117 (from geneSymbol) ENSMUST00000236350.1 uc294fwk.1 uc294fwk.2 uc294fwk.1 uc294fwk.2 
ENSMUST00000236359.2 Gm50295 ENSMUST00000236359.2 Gm50295 (from geneSymbol) ENSMUST00000236359.1 uc294fwt.1 uc294fwt.2 uc294fwt.1 uc294fwt.2 
ENSMUST00000236363.3 1700080C20Rik ENSMUST00000236363.3 1700080C20Rik (from geneSymbol) AK018900 ENSMUST00000236363.1 ENSMUST00000236363.2 uc294fwx.1 uc294fwx.2 uc294fwx.3 uc294fwx.1 uc294fwx.2 uc294fwx.3 
ENSMUST00000236376.2 Gm50306 ENSMUST00000236376.2 Gm50306 (from geneSymbol) ENSMUST00000236376.1 uc294fxk.1 uc294fxk.2 uc294fxk.1 uc294fxk.2 
ENSMUST00000236378.2 Vmn1r55 ENSMUST00000236378.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q8I6) E9Q8I6 E9Q8I6_MOUSE ENSMUST00000236378.1 Vmn1r55 uc294fxm.1 uc294fxm.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294fxm.1 uc294fxm.2 
ENSMUST00000236384.2 Gm50436 ENSMUST00000236384.2 Gm50436 (from geneSymbol) AK157105 ENSMUST00000236384.1 uc294fxs.1 uc294fxs.2 uc294fxs.1 uc294fxs.2 
ENSMUST00000236386.2 Pglyrp2 ENSMUST00000236386.2 peptidoglycan recognition protein 2, transcript variant 2 (from RefSeq NM_001271476.1) ENSMUST00000236386.1 NM_001271476 PGRP2_MOUSE Pglyrpl Pgrpl Q8K4I8 Q8VCS0 Q9QXZ1 Q9QXZ2 uc294fxu.1 uc294fxu.2 May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity. Reaction=Hydrolyzes the link between N-acetylmuramoyl residues and L- amino acid residues in certain cell-wall glycopeptides.; EC=3.5.1.28; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Secreted. Membrane. Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=TagL-alpha; IsoId=Q8VCS0-1; Sequence=Displayed; Name=2; Synonyms=TagL-beta; IsoId=Q8VCS0-2; Sequence=VSP_009081; Name=3; Synonyms=TagL-epsilon; IsoId=Q8VCS0-3; Sequence=VSP_009079, VSP_009080; Strongly expressed in liver and fetal liver. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. pattern recognition receptor signaling pathway immune system process extracellular region extracellular space zinc ion binding N-acetylmuramoyl-L-alanine amidase activity peptidoglycan catabolic process peptidoglycan receptor activity membrane detection of bacterium hydrolase activity antimicrobial humoral response killing of cells of other organism negative regulation of interferon-gamma production negative regulation of natural killer cell differentiation involved in immune response peptidoglycan binding growth of symbiont in host metal ion binding regulation of inflammatory response defense response to Gram-positive bacterium positive regulation of cytolysis in other organism uc294fxu.1 uc294fxu.2 
ENSMUST00000236394.2 Gm50207 ENSMUST00000236394.2 Gm50207 (from geneSymbol) ENSMUST00000236394.1 uc294fyb.1 uc294fyb.2 uc294fyb.1 uc294fyb.2 
ENSMUST00000236398.2 Gm50186 ENSMUST00000236398.2 Gm50186 (from geneSymbol) AK133491 ENSMUST00000236398.1 uc294fyf.1 uc294fyf.2 uc294fyf.1 uc294fyf.2 
ENSMUST00000236407.2 Gm50402 ENSMUST00000236407.2 Gm50402 (from geneSymbol) AK039111 ENSMUST00000236407.1 uc294fyn.1 uc294fyn.2 uc294fyn.1 uc294fyn.2 
ENSMUST00000236409.2 Wiz ENSMUST00000236409.2 widely-interspaced zinc finger motifs, transcript variant 4 (from RefSeq NM_001372227.1) A0A494BAG6 A0A494BAG6_MOUSE ENSMUST00000236409.1 NM_001372227 Wiz uc294fyp.1 uc294fyp.2 Nucleus nucleic acid binding uc294fyp.1 uc294fyp.2 
ENSMUST00000236411.2 4930415P13Rik ENSMUST00000236411.2 4930415P13Rik (from geneSymbol) AK015156 ENSMUST00000236411.1 uc294fyr.1 uc294fyr.2 uc294fyr.1 uc294fyr.2 
ENSMUST00000236435.2 Gm30288 ENSMUST00000236435.2 Gm30288 (from geneSymbol) ENSMUST00000236435.1 uc294fzp.1 uc294fzp.2 uc294fzp.1 uc294fzp.2 
ENSMUST00000236439.2 A930007I19Rik ENSMUST00000236439.2 A930007I19Rik (from geneSymbol) AK132712 ENSMUST00000236439.1 uc294fzt.1 uc294fzt.2 uc294fzt.1 uc294fzt.2 
ENSMUST00000236458.2 Gm32629 ENSMUST00000236458.2 Gm32629 (from geneSymbol) ENSMUST00000236458.1 uc294gal.1 uc294gal.2 uc294gal.1 uc294gal.2 
ENSMUST00000236459.2 ENSMUSG00000121757 ENSMUST00000236459.2 ENSMUSG00000121757 (from geneSymbol) ENSMUST00000236459.1 M19413 uc294gam.1 uc294gam.2 uc294gam.1 uc294gam.2 
ENSMUST00000236474.2 Gm41760 ENSMUST00000236474.2 Gm41760 (from geneSymbol) ENSMUST00000236474.1 LF201453 uc294gbb.1 uc294gbb.2 uc294gbb.1 uc294gbb.2 
ENSMUST00000236488.3 Gm50212 ENSMUST00000236488.3 Gm50212 (from geneSymbol) ENSMUST00000236488.1 ENSMUST00000236488.2 uc294gbp.1 uc294gbp.2 uc294gbp.3 uc294gbp.1 uc294gbp.2 uc294gbp.3 
ENSMUST00000236489.2 Gm36037 ENSMUST00000236489.2 Gm36037 (from geneSymbol) AK161373 ENSMUST00000236489.1 uc294gbq.1 uc294gbq.2 uc294gbq.1 uc294gbq.2 
ENSMUST00000236490.2 Gm41792 ENSMUST00000236490.2 Gm41792 (from geneSymbol) ENSMUST00000236490.1 uc294gbr.1 uc294gbr.2 uc294gbr.1 uc294gbr.2 
ENSMUST00000236510.2 Acy3 ENSMUST00000236510.2 aminoacylase 3, transcript variant 2 (from RefSeq NM_001302480.1) ACY3_MOUSE Aspa2 ENSMUST00000236510.1 NM_001302480 Q3UP59 Q91XE4 Q9DD17 uc294gck.1 uc294gck.2 This gene encodes a member of the aminoacylase family of enzymes. This enzyme specifically deacetylates N-acetyl aromatic amino acids and mercapturic acids. Action of this enzyme on metabolites of the environmental contaminant trichloroethylene leads to the generation of toxic products that may lead to kidney failure. This protein has been found to bind to the hepatitis C virus core protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids. Reaction=an N-acyl-aromatic L-alpha-amino acid + H2O = a carboxylate + an aromatic L-alpha-amino acid; Xref=Rhea:RHEA:54184, ChEBI:CHEBI:15377, ChEBI:CHEBI:29067, ChEBI:CHEBI:84824, ChEBI:CHEBI:138093; EC=3.5.1.114; Reaction=an N-acetyl-L-cysteine-S-conjugate + H2O = acetate + an S- substituted L-cysteine; Xref=Rhea:RHEA:36855, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:58717, ChEBI:CHEBI:58718; EC=3.5.1.114; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Kinetic parameters: KM=1.1 mM for S-benzyl-N-acetyl-L-cysteine ; KM=1.8 mM for N-acetyl-L-histidine ; KM=1.4 mM for N-acetyl-L-tyrosine ; KM=1.6 mM for N-acetyl-L-phenylalanine ; Vmax=11.7 umol/min/mg enzyme with S-benzyl-N-acetyl-L-cysteine as substrate ; Vmax=5.9 umol/min/mg enzyme with N-acetyl-L-histidine as substrate ; Vmax=7.5 umol/min/mg enzyme with N-acetyl-L-tyrosine as substrate ; Vmax=7.9 umol/min/mg enzyme with N-acetyl-L-phenylalanine as substrate ; pH dependence: Optimum pH is 7.5 with S-benzyl-N-acetyl-L-cysteine as substrate, 7.6 with N-acetyl-L-histidine as substrate, 7.6 with N-acetyl-L-tyrosine as substrate, and 7.7 with N-acetyl-L-phenylalanine as substrate. ; Exists as a mixture of homodimers and homotetramer, both catalytically active. Q91XE4; Q91XE4: Acy3; NbExp=4; IntAct=EBI-7378963, EBI-7378963; Q91XE4; P26664; Xeno; NbExp=6; IntAct=EBI-7378963, EBI-6941357; Apical cell membrane ; Peripheral membrane protein Cytoplasm Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm. Expressed predominantly in kidney and to a lesser extent in liver. Weakly expressed in heart, small intestine, brain, lung, testis, and stomach. Belongs to the AspA/AstE family. Aspartoacylase subfamily. aminoacylase activity protein binding cytoplasm cytosol plasma membrane membrane apical plasma membrane hydrolase activity hydrolase activity, acting on ester bonds hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides identical protein binding metal ion binding uc294gck.1 uc294gck.2 
ENSMUST00000236517.2 Gm50350 ENSMUST00000236517.2 Gm50350 (from geneSymbol) AK144971 ENSMUST00000236517.1 uc294gcr.1 uc294gcr.2 uc294gcr.1 uc294gcr.2 
ENSMUST00000236524.2 4930535F04Rik ENSMUST00000236524.2 4930535F04Rik (from geneSymbol) ENSMUST00000236524.1 uc294gcy.1 uc294gcy.2 uc294gcy.1 uc294gcy.2 
ENSMUST00000236526.2 1700061A03Rik ENSMUST00000236526.2 1700061A03Rik (from geneSymbol) AK006847 ENSMUST00000236526.1 uc294gda.1 uc294gda.2 uc294gda.1 uc294gda.2 
ENSMUST00000236541.2 Gm50152 ENSMUST00000236541.2 Gm50152 (from geneSymbol) ENSMUST00000236541.1 uc294gdp.1 uc294gdp.2 uc294gdp.1 uc294gdp.2 
ENSMUST00000236545.2 Vmn1r236 ENSMUST00000236545.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A494BB52) A0A494BB52 A0A494BB52_MOUSE ENSMUST00000236545.1 Vmn1r236 uc294gds.1 uc294gds.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294gds.1 uc294gds.2 
ENSMUST00000236559.2 Gm54798 ENSMUST00000236559.2 Gm54798 (from geneSymbol) AK017535 ENSMUST00000236559.1 uc294gef.1 uc294gef.2 uc294gef.1 uc294gef.2 
ENSMUST00000236560.2 Gm50388 ENSMUST00000236560.2 Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1) (PubMed:23217742, PubMed:25279699). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O- mannosyl glycan (PubMed:25279699). Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (PubMed:23217742). (from UniProt Q8BWP8) B3gnt1 B3gnt6 B4GA1_MOUSE B4gat1 BC038380 ENSMUST00000236560.1 Q3TY43 Q8BJH9 Q8BWP8 Q99LW7 uc294geg.1 uc294geg.2 Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1) (PubMed:23217742, PubMed:25279699). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O- mannosyl glycan (PubMed:25279699). Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (PubMed:23217742). Reaction=3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc- (1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP- alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib- ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P- alpha-D-Man)]-Thr-[protein] + H(+) + UDP; Xref=Rhea:RHEA:46860, Rhea:RHEA-COMP:15023, Rhea:RHEA-COMP:17482, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:142405, ChEBI:CHEBI:177336; Evidence= Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Protein modification; protein glycosylation. Interacts with LARGE1 and LARGE2. Golgi apparatus membrane ; Single-pass type II membrane protein. Note=Localizes near the trans-Golgi apparatus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BWP8-1; Sequence=Displayed; Name=2; IsoId=Q8BWP8-2; Sequence=VSP_014004, VSP_014005; Early embryonic lethality. Belongs to the glycosyltransferase 49 family. Golgi membrane Golgi apparatus protein glycosylation axon guidance glucuronosyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein O-linked mannosylation metal ion binding N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity poly-N-acetyllactosamine biosynthetic process uc294geg.1 uc294geg.2 
ENSMUST00000236562.2 Gm50339 ENSMUST00000236562.2 Gm50339 (from geneSymbol) ENSMUST00000236562.1 uc294gei.1 uc294gei.2 uc294gei.1 uc294gei.2 
ENSMUST00000236572.2 Gm10503 ENSMUST00000236572.2 Gm10503 (from geneSymbol) AK138161 ENSMUST00000236572.1 uc294ges.1 uc294ges.2 uc294ges.1 uc294ges.2 
ENSMUST00000236577.2 Gm50153 ENSMUST00000236577.2 Gm50153 (from geneSymbol) ENSMUST00000236577.1 uc294gex.1 uc294gex.2 uc294gex.1 uc294gex.2 
ENSMUST00000236582.2 Gm50203 ENSMUST00000236582.2 Gm50203 (from geneSymbol) AK131748 ENSMUST00000236582.1 uc294gfc.1 uc294gfc.2 uc294gfc.1 uc294gfc.2 
ENSMUST00000236586.3 Fech ENSMUST00000236586.3 ferrochelatase, transcript variant 1 (from RefSeq NM_007998.8) ENSMUST00000236586.1 ENSMUST00000236586.2 HEMH_MOUSE NM_007998 P22315 Q544X6 uc294gfg.1 uc294gfg.2 Catalyzes the ferrous insertion into protoporphyrin IX. Reaction=2 H(+) + heme b = Fe(2+) + protoporphyrin IX; Xref=Rhea:RHEA:22584, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:57306, ChEBI:CHEBI:60344; EC=4.98.1.1; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Note=Binds 1 [2Fe-2S] cluster.; Inhibited by nitric oxide (NO). The 2Fe-2S cluster could act as a NO sensor (By similarity). Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. Homodimer (By similarity). Interaction with PGRMC1; the interaction results in decreased FECH activity (PubMed:27599036). Interacts with ABCB10 and SLC25A37; this interaction forms an oligomeric complex (PubMed:20427704). Forms a complex with ABCB7 and ABCB10, where a dimeric FECH bridges ABCB7 and ABCB10 homodimers; this complex may be required for cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). Interacts with ABCB7 and ABCB10 (PubMed:30765471). P22315; O15173: PGRMC2; Xeno; NbExp=2; IntAct=EBI-7174007, EBI-1050125; Mitochondrion inner membrane ; Peripheral membrane protein; Matrix side. Erythroid and hepatic cells. During erythroid differentiation. Note=Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia. Belongs to the ferrochelatase family. Sequence=AAA37615.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; ferrochelatase activity iron ion binding protein binding mitochondrion mitochondrial inner membrane porphyrin-containing compound biosynthetic process heme biosynthetic process cholesterol metabolic process response to light stimulus detection of UV regulation of gene expression regulation of eIF2 alpha phosphorylation by heme membrane lyase activity heme binding erythrocyte differentiation iron-responsive element binding very-low-density lipoprotein particle assembly protoporphyrinogen IX metabolic process metal ion binding tetrapyrrole binding regulation of hemoglobin biosynthetic process iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding iron ion homeostasis uc294gfg.1 uc294gfg.2 
ENSMUST00000236591.2 Nfkb2 ENSMUST00000236591.2 NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I- kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome- mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65 (By similarity). In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. (from UniProt Q9WTK5) AF155372 ENSMUST00000236591.1 NFKB2_MOUSE Q9WTK5 uc294gfl.1 uc294gfl.2 NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I- kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome- mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65 (By similarity). In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Component of the NF-kappa-B RelB-p52 complex. Homodimer; component of the NF-kappa-B p52-p52 complex. Component of the NF-kappa- B p65-p52 complex. Component of the NF-kappa-B p52-c-Rel complex. NFKB2/p52 interacts with NFKBIE. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3 (By similarity). Directly interacts with MEN1 (By similarity). Q9WTK5; Q04207: Rela; NbExp=3; IntAct=EBI-1209166, EBI-644400; Q9WTK5; Q04863: Relb; NbExp=3; IntAct=EBI-1209166, EBI-1209145; Nucleus Cytoplasm Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Highly expressed in lymph nodes and thymus. The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of DNA-binding by p52 homodimers, and/or transcription activation. The glycine-rich region (GRR) appears to be a critical element in the generation of p52. While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p52 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing (By similarity). Subsequent to MAP3K14-dependent serine phosphorylation, p100 polyubiquitination occurs then triggering its proteasome-dependent processing. Constitutive processing is tightly suppressed by its C-terminal processing inhibitory domain, named PID, which contains the death domain. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding follicular dendritic cell differentiation germinal center formation DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated inflammatory response signal transduction I-kappaB kinase/NF-kappaB signaling aging extracellular matrix organization response to lipopolysaccharide Bcl3/NF-kappaB2 complex response to cytokine NIK/NF-kappaB signaling positive regulation of transcription from RNA polymerase II promoter rhythmic process lymph node development spleen development uc294gfl.1 uc294gfl.2 
ENSMUST00000236607.2 Tkfc ENSMUST00000236607.2 triokinase, FMN cyclase, transcript variant 2 (from RefSeq NM_001417865.1) Dak ENSMUST00000236607.1 NM_001417865 Q8VC30 TKFC_MOUSE Tkfc uc294ggb.1 uc294ggb.2 Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1- mediated cellular antiviral response. Reaction=ATP + dihydroxyacetone = ADP + dihydroxyacetone phosphate + H(+); Xref=Rhea:RHEA:15773, ChEBI:CHEBI:15378, ChEBI:CHEBI:16016, ChEBI:CHEBI:30616, ChEBI:CHEBI:57642, ChEBI:CHEBI:456216; EC=2.7.1.29; Reaction=ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate + H(+); Xref=Rhea:RHEA:13941, ChEBI:CHEBI:15378, ChEBI:CHEBI:17378, ChEBI:CHEBI:30616, ChEBI:CHEBI:59776, ChEBI:CHEBI:456216; EC=2.7.1.28; Reaction=FAD = AMP + H(+) + riboflavin cyclic-4',5'-phosphate; Xref=Rhea:RHEA:13729, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:76202, ChEBI:CHEBI:456215; EC=4.6.1.15; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence=; Note=Manganese or cobalt are requested for FAD-AMP lyase activity. ; Each activity is inhibited by the substrate(s) of the other. Homodimer (By similarity). Interacts with IFIH1 (via the CARD domains), the interaction is inhibited by viral infection (By similarity). DhaK and DhaL domains have differential roles, individually DhaK is inactive and DhaL displays cyclase but not kinase activity. Belongs to the dihydroxyacetone kinase (DAK) family. nucleotide binding catalytic activity glycerone kinase activity protein binding ATP binding cytosol glycerol metabolic process metabolic process kinase activity phosphorylation transferase activity lyase activity glycerol catabolic process FAD-AMP lyase (cyclizing) activity negative regulation of MDA-5 signaling pathway cellular carbohydrate metabolic process regulation of innate immune response carbohydrate phosphorylation metal ion binding triokinase activity fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate glycolytic process through fructose-1-phosphate uc294ggb.1 uc294ggb.2 
ENSMUST00000236611.2 Gm33732 ENSMUST00000236611.2 Gm33732 (from geneSymbol) AK139062 ENSMUST00000236611.1 uc294ggf.1 uc294ggf.2 uc294ggf.1 uc294ggf.2 
ENSMUST00000236620.2 ENSMUSG00000121305 ENSMUST00000236620.2 ENSMUSG00000121305 (from geneSymbol) ENSMUST00000236620.1 uc294ggo.1 uc294ggo.2 uc294ggo.1 uc294ggo.2 
ENSMUST00000236621.2 Gm5095 ENSMUST00000236621.2 predicted gene 5095 (from RefSeq NR_033454.1) ENSMUST00000236621.1 NR_033454 uc294ggp.1 uc294ggp.2 uc294ggp.1 uc294ggp.2 
ENSMUST00000236634.2 Spink6 ENSMUST00000236634.2 serine peptidase inhibitor, Kazal type 6, transcript variant 2 (from RefSeq NM_001357563.1) B9EJQ7 B9EJQ7_MOUSE ENSMUST00000236634.1 NM_001357563 Spink6 uc294ghc.1 uc294ghc.2 serine-type endopeptidase inhibitor activity negative regulation of endopeptidase activity uc294ghc.1 uc294ghc.2 
ENSMUST00000236639.2 Gm41757 ENSMUST00000236639.2 Gm41757 (from geneSymbol) ENSMUST00000236639.1 uc294ghh.1 uc294ghh.2 uc294ghh.1 uc294ghh.2 
ENSMUST00000236646.2 Gm50223 ENSMUST00000236646.2 Gm50223 (from geneSymbol) AK045080 ENSMUST00000236646.1 uc294gho.1 uc294gho.2 uc294gho.1 uc294gho.2 
ENSMUST00000236668.2 Gm36693 ENSMUST00000236668.2 Gm36693 (from geneSymbol) AK052522 ENSMUST00000236668.1 uc294gik.1 uc294gik.2 uc294gik.1 uc294gik.2 
ENSMUST00000236669.2 Gm54420 ENSMUST00000236669.2 Gm54420 (from geneSymbol) ENSMUST00000236669.1 uc294gil.1 uc294gil.2 uc294gil.1 uc294gil.2 
ENSMUST00000236670.3 Gm50288 ENSMUST00000236670.3 Gm50288 (from geneSymbol) ENSMUST00000236670.1 ENSMUST00000236670.2 uc294gim.1 uc294gim.2 uc294gim.3 uc294gim.1 uc294gim.2 uc294gim.3 
ENSMUST00000236674.2 Gm30192 ENSMUST00000236674.2 Gm30192 (from geneSymbol) ENSMUST00000236674.1 uc294gip.1 uc294gip.2 uc294gip.1 uc294gip.2 
ENSMUST00000236677.2 Gm35460 ENSMUST00000236677.2 Gm35460 (from geneSymbol) ENSMUST00000236677.1 uc294gis.1 uc294gis.2 uc294gis.1 uc294gis.2 
ENSMUST00000236682.2 Gm36043 ENSMUST00000236682.2 Gm36043 (from geneSymbol) AK035678 ENSMUST00000236682.1 uc294gix.1 uc294gix.2 uc294gix.1 uc294gix.2 
ENSMUST00000236686.4 Gm50394 ENSMUST00000236686.4 Gm50394 (from geneSymbol) AK153769 ENSMUST00000236686.1 ENSMUST00000236686.2 ENSMUST00000236686.3 uc294gjb.1 uc294gjb.2 uc294gjb.3 uc294gjb.4 uc294gjb.1 uc294gjb.2 uc294gjb.3 uc294gjb.4 
ENSMUST00000236689.2 Gm17266 ENSMUST00000236689.2 predicted gene, 17266 (from RefSeq NM_001370919.1) A0A494BAC1 A0A494BAC1_MOUSE ENSMUST00000236689.1 Gm17266 NM_001370919 uc294gje.1 uc294gje.2 uc294gje.1 uc294gje.2 
ENSMUST00000236713.2 Gm31503 ENSMUST00000236713.2 Gm31503 (from geneSymbol) AK145338 ENSMUST00000236713.1 uc294gkc.1 uc294gkc.2 uc294gkc.1 uc294gkc.2 
ENSMUST00000236720.2 4930588A03Rik ENSMUST00000236720.2 4930588A03Rik (from geneSymbol) AK016363 ENSMUST00000236720.1 uc294gki.1 uc294gki.2 uc294gki.1 uc294gki.2 
ENSMUST00000236724.2 Gm50398 ENSMUST00000236724.2 Gm50398 (from geneSymbol) ENSMUST00000236724.1 uc294gkm.1 uc294gkm.2 uc294gkm.1 uc294gkm.2 
ENSMUST00000236737.2 Asdurf ENSMUST00000236737.2 Asnsd1 upstream reading frame (from RefSeq NM_001353501.1) A0A494BB10 A0A494BB10_MOUSE ENSMUST00000236737.1 Gm50478 NM_001353501 uc294gkz.1 uc294gkz.2 uc294gkz.1 uc294gkz.2 
ENSMUST00000236745.2 Ubash3a ENSMUST00000236745.2 ubiquitin associated and SH3 domain containing, A (from RefSeq NM_177823.4) ENSMUST00000236745.1 NM_177823 Q3TED7 Q3V3E1 Sts2 UBS3A_MOUSE uc294glh.1 uc294glh.2 Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. Homodimer or homooligomer. Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins. Interacts with dynamin (By similarity). Cytoplasm Nucleus Has very nearly lost all enzyme activity. Has very low, but measurable tyrosine phosphatase activity at pH 5.0. regulation of cytokine production nucleus nucleoplasm cytoplasm Golgi apparatus negative regulation of T cell receptor signaling pathway platelet aggregation uc294glh.1 uc294glh.2 
ENSMUST00000236753.2 Gm52988 ENSMUST00000236753.2 Gm52988 (from geneSymbol) AK135960 ENSMUST00000236753.1 uc294glo.1 uc294glo.2 uc294glo.1 uc294glo.2 
ENSMUST00000236767.2 Tigd3 ENSMUST00000236767.2 tigger transposable element derived 3, transcript variant 1 (from RefSeq NM_198634.2) ENSMUST00000236767.1 NM_198634 Q7TM95 TIGD3_MOUSE uc294gmc.1 uc294gmc.2 Nucleus Belongs to the tigger transposable element derived protein family. molecular_function nucleic acid binding DNA binding cellular_component nucleus biological_process uc294gmc.1 uc294gmc.2 
ENSMUST00000236778.2 Gm34455 ENSMUST00000236778.2 Gm34455 (from geneSymbol) ENSMUST00000236778.1 uc294gmn.1 uc294gmn.2 uc294gmn.1 uc294gmn.2 
ENSMUST00000236793.2 Tmprss3 ENSMUST00000236793.2 Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro). (from UniProt Q8K1T0) AK158203 ENSMUST00000236793.1 Q812A6 Q8K1T0 Q8VDE0 TMPS3_MOUSE uc294gnc.1 uc294gnc.2 Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro). Endoplasmic reticulum membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8K1T0-1; Sequence=Displayed; Name=2; Synonyms=F; IsoId=Q8K1T0-2; Sequence=VSP_041581; Strongly expressed in liver, cochlea, brain, cerebellum, spleen, lung, and muscle and at a lower degree in retina, kidney, and heart. Expressed in the spiral ganglion, the cells supporting the organ of Corti and the stria vascularis. Isoform 2 is strongly expressed only in the cochlea with very faint expression in the cerebellum, spleen and muscle. Undergoes autoproteolytic activation. Belongs to the peptidase S1 family. serine-type endopeptidase activity scavenger receptor activity endoplasmic reticulum endoplasmic reticulum membrane proteolysis cellular sodium ion homeostasis endocytosis sensory perception of sound peptidase activity serine-type peptidase activity membrane integral component of membrane hydrolase activity sodium channel regulator activity neuronal cell body uc294gnc.1 uc294gnc.2 
ENSMUST00000236805.2 Gm38576 ENSMUST00000236805.2 predicted gene, 38576 (from RefSeq NR_155706.1) ENSMUST00000236805.1 NR_155706 uc294gnn.1 uc294gnn.2 uc294gnn.1 uc294gnn.2 
ENSMUST00000236815.2 Vmn1r-ps144 ENSMUST00000236815.2 Vmn1r-ps144 (from geneSymbol) ENSMUST00000236815.1 uc294gnx.1 uc294gnx.2 uc294gnx.1 uc294gnx.2 
ENSMUST00000236816.2 Gm19519 ENSMUST00000236816.2 Gm19519 (from geneSymbol) AK036854 ENSMUST00000236816.1 uc294gny.1 uc294gny.2 uc294gny.1 uc294gny.2 
ENSMUST00000236821.2 Vmn1r235 ENSMUST00000236821.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R297) AF394953 ENSMUST00000236821.1 Q8R297 Q8R297_MOUSE V1rf2 Vmn1r235 uc294god.1 uc294god.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294god.1 uc294god.2 
ENSMUST00000236822.2 Gm50431 ENSMUST00000236822.2 Gm50431 (from geneSymbol) AB349988 ENSMUST00000236822.1 uc294goe.1 uc294goe.2 uc294goe.1 uc294goe.2 
ENSMUST00000236828.2 Cd226 ENSMUST00000236828.2 Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T- lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding. (from UniProt Q8K4F0) AK036455 CD226_MOUSE ENSMUST00000236828.1 Pta1 Q8K4F0 uc294gok.1 uc294gok.2 Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T- lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding. Interacts with PVR and NECTIN2. Competes with PVRIG for NECTIN2-binding. Q8K4F0; P15151: PVR; Xeno; NbExp=3; IntAct=EBI-27124659, EBI-3919694; Cell membrane ; Single-pass type I membrane protein Phosphorylated. cytokine production positive regulation of natural killer cell cytokine production positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of immunoglobulin mediated immune response integrin binding protein binding plasma membrane cell adhesion external side of plasma membrane cell surface membrane integral component of membrane protein kinase binding positive regulation of interferon-gamma production positive regulation of mast cell activation positive regulation of natural killer cell mediated cytotoxicity cell adhesion molecule binding positive regulation of T cell receptor signaling pathway positive regulation of Fc receptor mediated stimulatory signaling pathway uc294gok.1 uc294gok.2 
ENSMUST00000236853.2 Cbs ENSMUST00000236853.2 Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). (from UniProt Q91WT9) AK085692 CBS_MOUSE ENSMUST00000236853.1 Q91WT9 Q91WU3 uc294gpi.1 uc294gpi.2 Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). Reaction=L-homocysteine + L-serine = H2O + L,L-cystathionine; Xref=Rhea:RHEA:10112, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384, ChEBI:CHEBI:58161, ChEBI:CHEBI:58199; EC=4.2.1.22; Evidence=; Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Allosterically activated by S-adenosyl- methionine/AdoMet. Activated by S-adenosylhomocysteine/AdoHcy. Binds non-covalently to a heme group that may control the redox sensitivity of the enzyme. Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2. Homotetramer. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91WT9-1; Sequence=Displayed; Name=2; IsoId=Q91WT9-2; Sequence=VSP_021790; Belongs to the cysteine synthase/cystathionine beta- synthase family. endochondral ossification blood vessel remodeling cystathionine beta-synthase activity cysteine synthase activity nucleus cytoplasm cysteine biosynthetic process from serine L-serine metabolic process superoxide metabolic process cellular amino acid biosynthetic process regulation of nitric oxide mediated signal transduction lyase activity cysteine biosynthetic process via cystathionine cysteine biosynthetic process transsulfuration oxygen binding enzyme binding heme binding cerebellum morphogenesis pyridoxal phosphate binding ubiquitin protein ligase binding identical protein binding protein homodimerization activity negative regulation of apoptotic process homocysteine catabolic process regulation of JUN kinase activity metal ion binding nitrite reductase (NO-forming) activity homocysteine metabolic process response to folic acid oxidation-reduction process maternal process involved in female pregnancy cartilage development involved in endochondral bone morphogenesis carbon monoxide binding nitric oxide binding hydrogen sulfide biosynthetic process cellular response to hypoxia modified amino acid binding regulation of blood vessel diameter S-adenosyl-L-methionine binding uc294gpi.1 uc294gpi.2 
ENSMUST00000236854.2 Gm50170 ENSMUST00000236854.2 Gm50170 (from geneSymbol) AK045294 ENSMUST00000236854.1 uc294gpj.1 uc294gpj.2 uc294gpj.1 uc294gpj.2 
ENSMUST00000236864.2 9830166K06Rik ENSMUST00000236864.2 RIKEN cDNA 9830166K06 gene (from RefSeq NR_045314.1) ENSMUST00000236864.1 NR_045314 uc294gpt.1 uc294gpt.2 uc294gpt.1 uc294gpt.2 
ENSMUST00000236871.2 Gm50221 ENSMUST00000236871.2 Gm50221 (from geneSymbol) ENSMUST00000236871.1 uc294gqa.1 uc294gqa.2 uc294gqa.1 uc294gqa.2 
ENSMUST00000236878.2 Gm50328 ENSMUST00000236878.2 Gm50328 (from geneSymbol) ENSMUST00000236878.1 uc294gqh.1 uc294gqh.2 uc294gqh.1 uc294gqh.2 
ENSMUST00000236889.2 Kctd16 ENSMUST00000236889.2 potassium channel tetramerisation domain containing 16, transcript variant 1 (from RefSeq NM_026135.2) ENSMUST00000236889.1 Gm1267 KCD16_MOUSE Kiaa1317 NM_026135 Q5DTY9 Q78Y50 uc294gqr.1 uc294gqr.2 Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization. Homopentamer; forms an open pentamer (By similarity). In contrast to other BTB domain-containing proteins, does not interact with CUL3 (By similarity). Interacts as a tetramer with GABRB1 and GABRB2 (PubMed:20400944). Presynaptic cell membrane Postsynaptic cell membrane Note=Colocalizes with GABRB1. Expressed in the brain, mainly in the hippocampus. molecular_function plasma membrane regulation of G-protein coupled receptor protein signaling pathway membrane cell junction presynaptic membrane receptor complex synapse postsynaptic membrane protein homooligomerization uc294gqr.1 uc294gqr.2 
ENSMUST00000236903.2 ENSMUSG00000121744 ENSMUST00000236903.2 ENSMUSG00000121744 (from geneSymbol) ENSMUST00000236903.1 uc294grf.1 uc294grf.2 uc294grf.1 uc294grf.2 
ENSMUST00000236905.3 Gm50321 ENSMUST00000236905.3 Gm50321 (from geneSymbol) BC056356 ENSMUST00000236905.1 ENSMUST00000236905.2 uc294grh.1 uc294grh.2 uc294grh.3 uc294grh.1 uc294grh.2 uc294grh.3 
ENSMUST00000236930.2 Gm46620 ENSMUST00000236930.2 Gm46620 (from geneSymbol) ENSMUST00000236930.1 FJ654109 uc294gsf.1 uc294gsf.2 uc294gsf.1 uc294gsf.2 
ENSMUST00000236936.2 Gm35610 ENSMUST00000236936.2 Gm35610 (from geneSymbol) ENSMUST00000236936.1 uc294gsl.1 uc294gsl.2 uc294gsl.1 uc294gsl.2 
ENSMUST00000236943.2 Gm50269 ENSMUST00000236943.2 Gm50269 (from geneSymbol) ENSMUST00000236943.1 uc294gss.1 uc294gss.2 uc294gss.1 uc294gss.2 
ENSMUST00000236944.2 ENSMUSG00000121758 ENSMUST00000236944.2 ENSMUSG00000121758 (from geneSymbol) ENSMUST00000236944.1 LF201002 uc294gst.1 uc294gst.2 uc294gst.1 uc294gst.2 
ENSMUST00000236953.2 Otud6b ENSMUST00000236953.2 Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; (from UniProt A0A0A0MQF5) A0A0A0MQF5 A0A0A0MQF5_MOUSE BC087552 ENSMUST00000236953.1 Otud6b uc294gtc.1 uc294gtc.2 Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=; uc294gtc.1 uc294gtc.2 
ENSMUST00000236957.3 Gm30889 ENSMUST00000236957.3 predicted gene, 30889 (from RefSeq NR_166715.1) ENSMUST00000236957.1 ENSMUST00000236957.2 NR_166715 uc294gtg.1 uc294gtg.2 uc294gtg.3 uc294gtg.1 uc294gtg.2 uc294gtg.3 
ENSMUST00000236959.2 Vmn1r183 ENSMUST00000236959.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8K3N5) ENSMUST00000236959.1 Q8K3N5 Q8K3N5_MOUSE V1rd15 Vmn1r183 uc294gti.1 uc294gti.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294gti.1 uc294gti.2 
ENSMUST00000236978.2 Scyl1 ENSMUST00000236978.2 SCY1-like 1 (S. cerevisiae), transcript variant 1 (from RefSeq NM_023912.3) ENSMUST00000236978.1 NM_023912 Q3TST7 Q3UKU0 Q8K222 Q9EQC5 SCYL1_MOUSE uc294gtz.1 uc294gtz.2 Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro. Homooligomer (By similarity). Interacts with GORAB. Interacts with COPA, COPB1 and COPB2. Interacts with AP2B1 (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm Endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus, cis-Golgi network Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1- independent manner. Expressed in diaphragm, quadriceps, thymus, liver, lung, spleen, kidney, heart and brain. Prominently expressed in neurons, and enriched at central nervous system synapses and neuromuscular junctions. The protein kinase domain is predicted to be catalytically inactive. Note=Defects in Scyl1 are the cause of the muscle deficient phenotype (mdf). Mice exhibit progressive neuromuscular atrophy, hindlimb paralysis, gait ataxia, abnormal hindlimb posture and tremor. Pathology of mdf comprises cerebellar atrophy, Purkinje cell loss and optic nerve atrophy. Belongs to the protein kinase superfamily. protein kinase activity protein binding ATP binding cytoplasm endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus cis-Golgi network microtubule organizing center cytosol cytoskeleton protein phosphorylation retrograde vesicle-mediated transport, Golgi to ER vesicle-mediated transport COPI vesicle coat uc294gtz.1 uc294gtz.2 
ENSMUST00000236988.3 2010320O07Rik ENSMUST00000236988.3 2010320O07Rik (from geneSymbol) AK008598 ENSMUST00000236988.1 ENSMUST00000236988.2 uc294guj.1 uc294guj.2 uc294guj.3 uc294guj.1 uc294guj.2 uc294guj.3 
ENSMUST00000237003.2 Cyp4f17 ENSMUST00000237003.2 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; (from UniProt G3UW78) Cyp4f17 ENSMUST00000237003.1 G3UW78 G3UW78_MOUSE uc294gux.1 uc294gux.2 Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Belongs to the cytochrome P450 family. molecular_function monooxygenase activity iron ion binding cellular_component biological_process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc294gux.1 uc294gux.2 
ENSMUST00000237004.2 Txnl1 ENSMUST00000237004.2 thioredoxin-like 1 (from RefSeq NM_016792.4) ENSMUST00000237004.1 NM_016792 O70379 Q3TI92 Q8CDN6 TXNL1_MOUSE Trp32 Txnl uc294guy.1 uc294guy.2 Active thioredoxin with a redox potential of about -250 mV. Component of the 19S regulatory cap of the 26S proteasome. Interacts with PSMD14/RPN11. Interacts with, and reduces EEF1A1 (By similarity). Cytoplasm Nucleus Note=At least 85% of the cellular TXNL1 is proteasome-associated. proteasome complex nucleus cytoplasm cytosol disulfide oxidoreductase activity cell redox homeostasis oxidation-reduction process uc294guy.1 uc294guy.2 
ENSMUST00000237005.3 Gm30571 ENSMUST00000237005.3 Gm30571 (from geneSymbol) AK081434 ENSMUST00000237005.1 ENSMUST00000237005.2 uc294guz.1 uc294guz.2 uc294guz.3 uc294guz.1 uc294guz.2 uc294guz.3 
ENSMUST00000237007.2 Gm50358 ENSMUST00000237007.2 Gm50358 (from geneSymbol) ENSMUST00000237007.1 uc294gvb.1 uc294gvb.2 uc294gvb.1 uc294gvb.2 
ENSMUST00000237019.2 Gm50256 ENSMUST00000237019.2 Gm50256 (from geneSymbol) ENSMUST00000237019.1 uc294gvn.1 uc294gvn.2 uc294gvn.1 uc294gvn.2 
ENSMUST00000237024.2 Vmn1r207 ENSMUST00000237024.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A494BA14) A0A494BA14 A0A494BA14_MOUSE ENSMUST00000237024.1 Vmn1r207 Vmn1r207-ps uc294gvr.1 uc294gvr.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294gvr.1 uc294gvr.2 
ENSMUST00000237028.2 Gm30094 ENSMUST00000237028.2 predicted gene, 30094 (from RefSeq NR_166834.1) ENSMUST00000237028.1 NR_166834 uc294gvv.1 uc294gvv.2 uc294gvv.1 uc294gvv.2 
ENSMUST00000237035.2 Gm50396 ENSMUST00000237035.2 Gm50396 (from geneSymbol) ENSMUST00000237035.1 uc294gwc.1 uc294gwc.2 uc294gwc.1 uc294gwc.2 
ENSMUST00000237036.2 Gm36315 ENSMUST00000237036.2 Gm36315 (from geneSymbol) ENSMUST00000237036.1 uc294gwd.1 uc294gwd.2 uc294gwd.1 uc294gwd.2 
ENSMUST00000237047.2 1700030N03Rik ENSMUST00000237047.2 1700030N03Rik (from geneSymbol) AK077035 ENSMUST00000237047.1 uc294gwn.1 uc294gwn.2 uc294gwn.1 uc294gwn.2 
ENSMUST00000237056.3 4930592I03Rik ENSMUST00000237056.3 4930592I03Rik (from geneSymbol) AK077183 ENSMUST00000237056.1 ENSMUST00000237056.2 uc294gwv.1 uc294gwv.2 uc294gwv.3 uc294gwv.1 uc294gwv.2 uc294gwv.3 
ENSMUST00000237057.2 Gm50281 ENSMUST00000237057.2 Gm50281 (from geneSymbol) AK144262 ENSMUST00000237057.1 uc294gww.1 uc294gww.2 uc294gww.1 uc294gww.2 
ENSMUST00000237075.2 Gm35406 ENSMUST00000237075.2 Gm35406 (from geneSymbol) ENSMUST00000237075.1 uc294gxn.1 uc294gxn.2 uc294gxn.1 uc294gxn.2 
ENSMUST00000237095.2 Ik ENSMUST00000237095.2 Nucleus (from UniProt A0A494BAW7) A0A494BAW7 A0A494BAW7_MOUSE AK088908 ENSMUST00000237095.1 Ik uc294gyg.1 uc294gyg.2 Nucleus nucleus uc294gyg.1 uc294gyg.2 
ENSMUST00000237098.2 Elovl3 ENSMUST00000237098.2 ELOVL fatty acid elongase 3, transcript variant 1 (from RefSeq NM_007703.2) Cig30 ELOV3_MOUSE ENSMUST00000237098.1 Elovl3 NM_007703 O35949 uc294gyj.1 uc294gyj.2 Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Participates in the formation of certain VLCFA and triglycerides in certain cells of the hair follicles and the sebaceous glands, required for skin barrier function. Critical enzyme for lipid accumulation and metabolic activity in brown adipocytes during the early phase of the tissue recruitment. Plays a role in lipid storage and in resistance to diet-induced obesity. Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long- chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=2.3.1.199; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32728; Evidence=; Reaction=eicosanoyl-CoA + H(+) + malonyl-CoA = 3-oxodocosanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35327, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:57384, ChEBI:CHEBI:71451; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35328; Evidence=; Reaction=H(+) + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35315, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57384, ChEBI:CHEBI:71407; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35316; Evidence=; Reaction=H(+) + malonyl-CoA + octadecanoyl-CoA = 3-oxoeicosanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35319, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:57394, ChEBI:CHEBI:65115; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35320; Evidence=; Reaction=(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3- oxoicosenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36511, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:57387, ChEBI:CHEBI:74011; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36512; Evidence=; Reaction=(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)- 3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36503, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:57384, ChEBI:CHEBI:74012; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36504; Evidence=; Reaction=(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36523, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74034, ChEBI:CHEBI:74054; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36524; Evidence=; Reaction=docosanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetracosanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36507, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:65059, ChEBI:CHEBI:73977; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36508; Evidence=; Reaction=H(+) + malonyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:39167, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57349, ChEBI:CHEBI:57384, ChEBI:CHEBI:57385; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39168; Evidence=; Lipid metabolism; polyunsaturated fatty acid biosynthesis. Endoplasmic reticulum membrane ; Multi- pass membrane protein Expressed in brown adipose tissue and liver. In the skin, strong expressed in the cells of the inner layer of the outer root sheath of the hair follicles and in the sebocytes of the sebaceous glands. Hardly detectable in the epidermis and not at all in fibroblasts. Strongly up-regulated in brown adipose tissue in conditions of brown fat recruitment, such as cold stress, perinatal development and after diet-induced thermogenesis. A synergistic action of both catecholamines and glucocorticoids is required for the induction. N-Glycosylated. Mutant mice grow normally and are fertile. They display a sparse hair coat, a hyperplastic pilosebaceous system and their hair lipid content is disturbed with exceptionally high levels of eicosenoic acid (20:1). In the triglyceride fraction, fatty acids longer than 20 carbon atoms are almost undetectable. As a result, mice exhibited a severe defect in water repulsion and increased trans- epidermal water loss. When exposed to cold stress, mutants exhibit a significantly reduced VLCFA elongation activity in brown adipose tissue, but only during the initial phase. Cold-acclimated mutants are equally efficient as normal mice at elongating fatty acids. Mutant mice are lean and resistant to diet-induced weight gain, they show normal food intake but increased metabolic rate, and show reduced hepatic lipogenesis and triglycerides synthesis. Belongs to the ELO family. ELOVL3 subfamily. endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process fatty acid elongase activity membrane integral component of membrane transferase activity fatty acid elongation, saturated fatty acid sphingolipid biosynthetic process integral component of endoplasmic reticulum membrane fatty acid elongation, monounsaturated fatty acid fatty acid elongation, polyunsaturated fatty acid long-chain fatty-acyl-CoA biosynthetic process very long-chain fatty acid biosynthetic process 3-oxo-arachidoyl-CoA synthase activity 3-oxo-cerotoyl-CoA synthase activity 3-oxo-lignoceronyl-CoA synthase activity uc294gyj.1 uc294gyj.2 
ENSMUST00000237102.3 Gm50133 ENSMUST00000237102.3 Gm50133 (from geneSymbol) ENSMUST00000237102.1 ENSMUST00000237102.2 uc294gyn.1 uc294gyn.2 uc294gyn.3 uc294gyn.1 uc294gyn.2 uc294gyn.3 
ENSMUST00000237104.2 Asah2 ENSMUST00000237104.2 Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:10753931, PubMed:10652340, PubMed:16380386). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:14557071). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:10652340, PubMed:21613224). Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (PubMed:16126722). Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1- phosphate inside and outside cells (PubMed:16126722). This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (PubMed:16380386). (from UniProt Q9JHE3) AB037181 ASAH2_MOUSE ENSMUST00000237104.1 Q3UWP9 Q8BNP0 Q8BQN7 Q8R236 Q9JHE3 uc294gyp.1 uc294gyp.2 Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:10753931, PubMed:10652340, PubMed:16380386). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:14557071). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:10652340, PubMed:21613224). Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (PubMed:16126722). Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1- phosphate inside and outside cells (PubMed:16126722). This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (PubMed:16380386). Reaction=an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine; Xref=Rhea:RHEA:20856, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868, ChEBI:CHEBI:52639, ChEBI:CHEBI:57756; EC=3.5.1.23; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20857; Evidence=; Reaction=H2O + N-hexadecanoylsphing-4-enine = hexadecanoate + sphing-4- enine; Xref=Rhea:RHEA:38891, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:57756, ChEBI:CHEBI:72959; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38892; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38893; Evidence=; Reaction=H2O + N-dodecanoylsphing-4-enine = dodecanoate + sphing-4- enine; Xref=Rhea:RHEA:41291, ChEBI:CHEBI:15377, ChEBI:CHEBI:18262, ChEBI:CHEBI:57756, ChEBI:CHEBI:72956; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41292; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:41293; Evidence=; Reaction=H2O + N-octadecanoylsphing-4-enine = octadecanoate + sphing-4- enine; Xref=Rhea:RHEA:41279, ChEBI:CHEBI:15377, ChEBI:CHEBI:25629, ChEBI:CHEBI:57756, ChEBI:CHEBI:72961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41280; Evidence=; Reaction=H2O + N-octanoylsphing-4-enine = octanoate + sphing-4-enine; Xref=Rhea:RHEA:45092, ChEBI:CHEBI:15377, ChEBI:CHEBI:25646, ChEBI:CHEBI:45815, ChEBI:CHEBI:57756; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45093; Evidence=; Reaction=H2O + N-(hexanoyl)sphing-4-enine = hexanoate + sphing-4-enine; Xref=Rhea:RHEA:41295, ChEBI:CHEBI:15377, ChEBI:CHEBI:17120, ChEBI:CHEBI:57756, ChEBI:CHEBI:63867; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41296; Evidence=; Reaction=H2O + N-tetradecanoylsphing-4-enine = sphing-4-enine + tetradecanoate; Xref=Rhea:RHEA:41287, ChEBI:CHEBI:15377, ChEBI:CHEBI:30807, ChEBI:CHEBI:57756, ChEBI:CHEBI:72957; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:41289; Evidence=; Reaction=H2O + N-(9Z-octadecenoyl)-sphing-4-enine = (9Z)-octadecenoate + sphing-4-enine; Xref=Rhea:RHEA:41299, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57756, ChEBI:CHEBI:77996; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41300; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:41301; Evidence=; Reaction=H2O + N-(15Z-tetracosenoyl)-sphing-4-enine = (15Z)- tetracosenoate + sphing-4-enine; Xref=Rhea:RHEA:41267, ChEBI:CHEBI:15377, ChEBI:CHEBI:32392, ChEBI:CHEBI:57756, ChEBI:CHEBI:74450; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:41269; Evidence=; Reaction=hexadecanoate + sphinganine = H2O + N-hexadecanoylsphinganine; Xref=Rhea:RHEA:43440, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:57817, ChEBI:CHEBI:67042; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:43442; Evidence=; Reaction=H2O + N-(octadecanoyl)-sphinganine = octadecanoate + sphinganine; Xref=Rhea:RHEA:45008, ChEBI:CHEBI:15377, ChEBI:CHEBI:25629, ChEBI:CHEBI:57817, ChEBI:CHEBI:67033; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45009; Evidence=; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Inhibited by D-erythro-MAPP. Kinetic parameters: KM=22.3 mM for C12-4-nitrobenzo-2-oxa-1,3-diazole-ceramide ; KM=72.4 mM for N-hexadecanoylsphing-4-enine ; Vmax=29.1 umol/min/mg enzyme with C12-4-nitrobenzo-2-oxa-1,3-diazole- ceramide as substrate ; Vmax=3.6 umol/min/mg enzyme with N-hexadecanoylsphing-4-enine as substrate ; pH dependence: Optimum pH is 7.5. ; Lipid metabolism; sphingolipid metabolism. May interact with CAV1. [Neutral ceramidase]: Cell membrane ingle-pass type II membrane protein Membrane raft ; Single-pass type II membrane protein Membrane, caveola ; Single-pass type II membrane protein Golgi apparatus membrane ; Single-pass type II membrane protein Mitochondrion Secreted, extracellular exosome Note=Enriched in exosomes upon stimulation by cytokine (By similarity). Enriched in caveolae and lipid rafts (PubMed:12921776). [Neutral ceramidase soluble form]: Secreted Widely expressed (PubMed:10753931, PubMed:14557071). Strongly expressed in small intestine and to a lower extent in liver and kidney (PubMed:10753931). Highly expressed in duodenum, jejunum and ileum along the brush border of the small intestine (at protein level) (PubMed:16380386). Proteolytic cleavage of the N-terminus removes the signal-anchor and produces a soluble form of the protein. N-glycosylated. Required for enzyme activity. O-glycosylated. Required to retain it as a type II membrane protein at the cell surface. Phosphorylated. May prevent ubiquitination and subsequent degradation. Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by nitric oxide. Homozygous knockout mice have a normal life span and do not show obvious abnormalities or major alterations in total ceramide levels in tissues (PubMed:16380386). However, they are deficient in the intestinal digestion of dietary ceramides (PubMed:16380386). A decrease in total ceramides in liver is also observed (PubMed:21613224). Belongs to the neutral ceramidase family. Golgi membrane calcium ion binding protein binding extracellular region extracellular space mitochondrion Golgi apparatus plasma membrane integral component of plasma membrane caveola lipid metabolic process sphingolipid metabolic process sphingosine metabolic process ceramide metabolic process apoptotic process regulation of mitotic cell cycle zinc ion binding response to organic substance membrane integral component of membrane hydrolase activity ceramidase activity long-chain fatty acid biosynthetic process lipid digestion membrane raft sphingosine biosynthetic process ceramide biosynthetic process ceramide catabolic process metal ion binding extracellular exosome phytoceramidase activity cellular response to cytokine stimulus dihydroceramidase activity negative regulation of apoptotic signaling pathway uc294gyp.1 uc294gyp.2 
ENSMUST00000237105.2 Gm50140 ENSMUST00000237105.2 Gm50140 (from geneSymbol) ENSMUST00000237105.1 uc294gyq.1 uc294gyq.2 uc294gyq.1 uc294gyq.2 
ENSMUST00000237107.2 Vmn1r191 ENSMUST00000237107.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8K4D0) ENSMUST00000237107.1 Q8K4D0 Q8K4D0_MOUSE V1rh15 Vmn1r191 uc294gys.1 uc294gys.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294gys.1 uc294gys.2 
ENSMUST00000237109.2 Vmn1r88 ENSMUST00000237109.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt E9Q235) E9Q235 E9Q235_MOUSE ENSMUST00000237109.1 Vmn1r86 Vmn1r88 uc294gyu.1 uc294gyu.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294gyu.1 uc294gyu.2 
ENSMUST00000237123.3 Gm50145 ENSMUST00000237123.3 Gm50145 (from geneSymbol) ENSMUST00000237123.1 ENSMUST00000237123.2 uc294gzi.1 uc294gzi.2 uc294gzi.3 uc294gzi.1 uc294gzi.2 uc294gzi.3 
ENSMUST00000237124.2 Gm18280 ENSMUST00000237124.2 predicted gene, 18280 (from RefSeq NR_169052.1) ENSMUST00000237124.1 NR_169052 uc294gzj.1 uc294gzj.2 uc294gzj.1 uc294gzj.2 
ENSMUST00000237142.2 Ankrd1 ENSMUST00000237142.2 ankyrin repeat domain 1 (from RefSeq NM_013468.3) ANKR1_MOUSE Carp ENSMUST00000237142.1 NM_013468 O55014 Q3UIF7 Q3UJ39 Q792Q9 Q9CR42 uc294hab.1 uc294hab.2 May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Interacts with TTN/titin and YBX1. Q9CR42; P09405: Ncl; NbExp=5; IntAct=EBI-8308696, EBI-641864; Q9CR42; P19338: NCL; Xeno; NbExp=2; IntAct=EBI-8308696, EBI-346967; Nucleus Expressed in heart, cardiac muscle. Expression was first clearly detected as early as 8.5 dpc specifically in heart and is regulated temporally and spatially in the myocardium. Transcripts are present in uniformly high levels in the myocardium. Throughout cardiac development, expression is specific for the myocardium; endocardial cushions and valves exhibit only background levels of signal. Transcript levels persist but gradually decrease in neonatal, 2-week-old, and adult hearts. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding fibrillar center p53 binding DNA binding transcription coactivator activity transcription corepressor activity protein binding nucleus transcription factor complex cytoplasm cytosol regulation of transcription from RNA polymerase II promoter transcription factor binding positive regulation of neuron projection development myofibril titin binding I band macromolecular complex cellular response to drug skeletal muscle cell differentiation response to muscle stretch histone deacetylase binding positive regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of protein secretion cardiac muscle tissue morphogenesis RNA polymerase II sequence-specific DNA binding transcription factor binding R-SMAD binding protein kinase C signaling cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to transforming growth factor beta stimulus positive regulation of nucleic acid-templated transcription negative regulation of DNA biosynthetic process uc294hab.1 uc294hab.2 
ENSMUST00000237155.2 Vmn1r237 ENSMUST00000237155.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R296) ENSMUST00000237155.1 Q8R296 Q8R296_MOUSE V1rf3 Vmn1r237 uc294hao.1 uc294hao.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294hao.1 uc294hao.2 
ENSMUST00000237171.2 Gm45928 ENSMUST00000237171.2 predicted gene, 45928, transcript variant 2 (from RefSeq NR_132309.2) A0A494B974 A0A494B974_MOUSE ENSMUST00000237171.1 Gm45928 NR_132309 uc294hba.1 uc294hba.2 This locus represents naturally occurring readthrough transcription between the neighboring Clcf1 (cardiotrophin-like cytokine factor 1) and Pold4 (polymerase (DNA-directed), delta 4) genes on chromosome 19. The readthrough transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015]. nucleus DNA replication uc294hba.1 uc294hba.2 
ENSMUST00000237173.2 Gm50128 ENSMUST00000237173.2 Gm50128 (from geneSymbol) ENSMUST00000237173.1 uc294hbc.1 uc294hbc.2 uc294hbc.1 uc294hbc.2 
ENSMUST00000237179.4 Gm50228 ENSMUST00000237179.4 Gm50228 (from geneSymbol) ENSMUST00000237179.1 ENSMUST00000237179.2 ENSMUST00000237179.3 uc294hbi.1 uc294hbi.2 uc294hbi.3 uc294hbi.4 uc294hbi.1 uc294hbi.2 uc294hbi.3 uc294hbi.4 
ENSMUST00000237191.2 Kctd16 ENSMUST00000237191.2 Kctd16 (from geneSymbol) AK021087 ENSMUST00000237191.1 uc294hbu.1 uc294hbu.2 uc294hbu.1 uc294hbu.2 
ENSMUST00000237193.2 Gm50206 ENSMUST00000237193.2 Gm50206 (from geneSymbol) AK036795 ENSMUST00000237193.1 uc294hbw.1 uc294hbw.2 uc294hbw.1 uc294hbw.2 
ENSMUST00000237195.2 Vmn1r233 ENSMUST00000237195.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R294) ENSMUST00000237195.1 Q8R294 Q8R294_MOUSE V1rf5 Vmn1r233 uc294hby.1 uc294hby.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294hby.1 uc294hby.2 
ENSMUST00000237205.2 Gm50244 ENSMUST00000237205.2 Gm50244 (from geneSymbol) ENSMUST00000237205.1 uc294hci.1 uc294hci.2 uc294hci.1 uc294hci.2 
ENSMUST00000237214.2 Vmn1r-ps14 ENSMUST00000237214.2 Vmn1r-ps14 (from geneSymbol) ENSMUST00000237214.1 uc294hcr.1 uc294hcr.2 uc294hcr.1 uc294hcr.2 
ENSMUST00000237218.2 Gm50368 ENSMUST00000237218.2 Gm50368 (from geneSymbol) ENSMUST00000237218.1 uc294hcv.1 uc294hcv.2 uc294hcv.1 uc294hcv.2 
ENSMUST00000237231.2 Gm52981 ENSMUST00000237231.2 Gm52981 (from geneSymbol) AK137243 ENSMUST00000237231.1 uc294hdi.1 uc294hdi.2 uc294hdi.1 uc294hdi.2 
ENSMUST00000237254.2 Gm50254 ENSMUST00000237254.2 Gm50254 (from geneSymbol) ENSMUST00000237254.1 uc294hef.1 uc294hef.2 uc294hef.1 uc294hef.2 
ENSMUST00000237256.3 D330050I16Rik ENSMUST00000237256.3 RIKEN cDNA D330050I16 gene (from RefSeq NR_033224.1) ENSMUST00000237256.1 ENSMUST00000237256.2 NR_033224 uc294heh.1 uc294heh.2 uc294heh.3 uc294heh.1 uc294heh.2 uc294heh.3 
ENSMUST00000237263.2 BC031181 ENSMUST00000237263.2 cDNA sequence BC031181, transcript variant 1 (from RefSeq NM_001001181.4) CR032_MOUSE ENSMUST00000237263.1 NM_001001181 Q3V3U8 Q91WE4 uc294heo.1 uc294heo.2 May activate the NF-kappa-B signaling pathway. Interacts with DERL1 and AMFR. Endoplasmic reticulum Lipid droplet Undergoes ER-associated degradation (ERAD). Belongs to the UPF0729 family. cellular_component uc294heo.1 uc294heo.2 
ENSMUST00000237264.2 Gm41555 ENSMUST00000237264.2 Gm41555 (from geneSymbol) ENSMUST00000237264.1 uc294hep.1 uc294hep.2 uc294hep.1 uc294hep.2 
ENSMUST00000237266.3 Gm50401 ENSMUST00000237266.3 Gm50401 (from geneSymbol) ENSMUST00000237266.1 ENSMUST00000237266.2 uc294her.1 uc294her.2 uc294her.3 uc294her.1 uc294her.2 uc294her.3 
ENSMUST00000237283.2 Gm50225 ENSMUST00000237283.2 Gm50225 (from geneSymbol) ENSMUST00000237283.1 uc294hfi.1 uc294hfi.2 uc294hfi.1 uc294hfi.2 
ENSMUST00000237298.3 4930414N06Rik ENSMUST00000237298.3 4930414N06Rik (from geneSymbol) AK015139 ENSMUST00000237298.1 ENSMUST00000237298.2 uc294hfx.1 uc294hfx.2 uc294hfx.3 uc294hfx.1 uc294hfx.2 uc294hfx.3 
ENSMUST00000237300.2 Gm50324 ENSMUST00000237300.2 Gm50324 (from geneSymbol) ENSMUST00000237300.1 uc294hfz.1 uc294hfz.2 uc294hfz.1 uc294hfz.2 
ENSMUST00000237322.2 Gm50298 ENSMUST00000237322.2 Gm50298 (from geneSymbol) ENSMUST00000237322.1 uc294hgv.1 uc294hgv.2 uc294hgv.1 uc294hgv.2 
ENSMUST00000237328.2 Gm19784 ENSMUST00000237328.2 predicted gene, 19784 (from RefSeq NR_040461.1) ENSMUST00000237328.1 NR_040461 uc294hhb.1 uc294hhb.2 uc294hhb.1 uc294hhb.2 
ENSMUST00000237332.2 Gm50166 ENSMUST00000237332.2 Gm50166 (from geneSymbol) AK133421 ENSMUST00000237332.1 uc294hhf.1 uc294hhf.2 uc294hhf.1 uc294hhf.2 
ENSMUST00000237333.2 Ptar1 ENSMUST00000237333.2 protein prenyltransferase alpha subunit repeat containing 1 (from RefSeq NM_028208.1) A0A494B9V8 A0A494B9V8_MOUSE ENSMUST00000237333.1 NM_028208 Ptar1 uc294hhg.1 uc294hhg.2 Belongs to the protein prenyltransferase subunit alpha family. cytoplasm protein prenyltransferase activity protein prenylation uc294hhg.1 uc294hhg.2 
ENSMUST00000237341.2 Ndufs8 ENSMUST00000237341.2 NADH:ubiquinone oxidoreductase core subunit S8, transcript variant 2 (from RefSeq NM_001271443.1) ENSMUST00000237341.1 NDUS8_MOUSE NM_001271443 Q8K3J1 uc294hho.1 uc294hho.2 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity). Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 2 [4Fe-4S] cluster. ; Complex I is composed of 45 different subunits (By similarity). This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Interacts with RAB5IF (PubMed:31536960). Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side Belongs to the complex I 23 kDa subunit family. NADH dehydrogenase activity mitochondrion mitochondrial respiratory chain complex I mitochondrial electron transport, NADH to ubiquinone response to oxidative stress NADH dehydrogenase (ubiquinone) activity aerobic respiration membrane oxidoreductase activity oxidoreductase activity, acting on NAD(P)H mitochondrial respiratory chain complex I assembly metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding oxidation-reduction process respiratory chain uc294hho.1 uc294hho.2 
ENSMUST00000237347.2 Nmrk1 ENSMUST00000237347.2 nicotinamide riboside kinase 1 (from RefSeq NM_145497.2) ENSMUST00000237347.1 NM_145497 NRK1_MOUSE Nrk1 Q3TDW3 Q91W63 uc294hhu.1 uc294hhu.2 Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reaction=ATP + beta-nicotinamide D-riboside = ADP + beta-nicotinamide D-ribonucleotide + H(+); Xref=Rhea:RHEA:14017, ChEBI:CHEBI:14649, ChEBI:CHEBI:15378, ChEBI:CHEBI:15927, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=2.7.1.22; Evidence=; Reaction=ATP + beta-D-ribosylnicotinate = ADP + H(+) + nicotinate beta- D-ribonucleotide; Xref=Rhea:RHEA:25568, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57502, ChEBI:CHEBI:58527, ChEBI:CHEBI:456216; EC=2.7.1.173; Evidence=; Cofactor biosynthesis; NAD(+) biosynthesis. Monomer. Belongs to the uridine kinase family. NRK subfamily. nucleotide binding ATP binding cellular_component NAD biosynthetic process kinase activity phosphorylation transferase activity pyridine nucleotide biosynthetic process metal ion binding ribosylnicotinamide kinase activity ribosylnicotinate kinase activity uc294hhu.1 uc294hhu.2 
ENSMUST00000237355.2 Gramd2b ENSMUST00000237355.2 Gramd2b (from geneSymbol) AK164050 ENSMUST00000237355.1 Gramd2b Gramd3 Q9D2W5 Q9D2W5_MOUSE uc294hib.1 uc294hib.2 membrane integral component of membrane uc294hib.1 uc294hib.2 
ENSMUST00000237370.3 Gm31356 ENSMUST00000237370.3 Gm31356 (from geneSymbol) ENSMUST00000237370.1 ENSMUST00000237370.2 uc294hiq.1 uc294hiq.2 uc294hiq.3 uc294hiq.1 uc294hiq.2 uc294hiq.3 
ENSMUST00000237374.2 Gm50419 ENSMUST00000237374.2 Gm50419 (from geneSymbol) ENSMUST00000237374.1 uc294hit.1 uc294hit.2 uc294hit.1 uc294hit.2 
ENSMUST00000237375.2 Cystm1 ENSMUST00000237375.2 Membrane ; Single-pass membrane protein (from UniProt Q8K353) BC028765 CYTM1_MOUSE ENSMUST00000237375.1 Q8BMU1 Q8K353 uc294hiu.1 uc294hiu.2 Membrane ; Single-pass membrane protein Belongs to the CYSTM1 family. molecular_function membrane integral component of membrane uc294hiu.1 uc294hiu.2 
ENSMUST00000237398.2 9130016M20Rik ENSMUST00000237398.2 9130016M20Rik (from geneSymbol) ENSMUST00000237398.1 uc294hjr.1 uc294hjr.2 uc294hjr.1 uc294hjr.2 
ENSMUST00000237400.2 Nars1 ENSMUST00000237400.2 asparaginyl-tRNA synthetase 1, transcript variant 4 (from RefSeq NM_001377022.1) ENSMUST00000237400.1 NM_001377022 Nars Nars1 Q3T9A7 Q7TPX0 Q8BP47 Q9CRY5 SYNC_MOUSE uc294hjt.1 uc294hjt.2 Catalyzes the attachment of asparagine to tRNA(Asn) in a two- step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells. Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells. Reaction=ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L- asparaginyl-tRNA(Asn); Xref=Rhea:RHEA:11180, Rhea:RHEA-COMP:9659, Rhea:RHEA-COMP:9674, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58048, ChEBI:CHEBI:78442, ChEBI:CHEBI:78515, ChEBI:CHEBI:456215; EC=6.1.1.22; Evidence=; Homodimer. Cytoplasm The N-terminal domain (1-77) recruits and activates specific immune cells by interacting with CCR3-expressing cells. Belongs to the class-II aminoacyl-tRNA synthetase family. Sequence=AAH52849.1; Type=Erroneous initiation; Evidence=; Sequence=BAB29032.1; Type=Erroneous initiation; Evidence=; nucleotide binding nucleic acid binding aminoacyl-tRNA ligase activity asparagine-tRNA ligase activity ATP binding cytoplasm mitochondrion cytosol translation tRNA aminoacylation for protein translation asparaginyl-tRNA aminoacylation ligase activity uc294hjt.1 uc294hjt.2 
ENSMUST00000237403.3 4930549G23Rik ENSMUST00000237403.3 4930549G23Rik (from geneSymbol) AK016077 ENSMUST00000237403.1 ENSMUST00000237403.2 uc294hjw.1 uc294hjw.2 uc294hjw.3 uc294hjw.1 uc294hjw.2 uc294hjw.3 
ENSMUST00000237404.2 Gm50211 ENSMUST00000237404.2 Gm50211 (from geneSymbol) ENSMUST00000237404.1 uc294hjx.1 uc294hjx.2 uc294hjx.1 uc294hjx.2 
ENSMUST00000237407.2 Kif20a ENSMUST00000237407.2 kinesin family member 20A, transcript variant 3 (from RefSeq NM_009004.4) ENSMUST00000237407.1 KI20A_MOUSE NM_009004 P97329 Q542M4 Rab6kifl uc294hka.1 uc294hka.2 Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle (By similarity). Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. Golgi apparatus Cytoplasm, cytoskeleton, spindle Note=Localizes to the spindle midzone during anaphase and telophase. Ubiquitously expressed, with highest levels in spleen and testis. Phosphorylated by PLK1 at Ser-527 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. nucleotide binding mitotic cytokinesis microtubule bundle formation microtubule motor activity ATP binding nucleus nucleoplasm cytoplasm Golgi apparatus spindle cytoskeleton kinesin complex microtubule microtubule-based movement microtubule binding protein transport ATPase activity protein kinase binding midbody cleavage furrow regulation of cytokinesis intercellular bridge uc294hka.1 uc294hka.2 
ENSMUST00000237418.2 Gm50248 ENSMUST00000237418.2 Gm50248 (from geneSymbol) ENSMUST00000237418.1 uc294hkk.1 uc294hkk.2 uc294hkk.1 uc294hkk.2 
ENSMUST00000237423.2 Gm50130 ENSMUST00000237423.2 Gm50130 (from geneSymbol) AK135120 ENSMUST00000237423.1 uc294hko.1 uc294hko.2 uc294hko.1 uc294hko.2 
ENSMUST00000237431.2 Rpl17 ENSMUST00000237431.2 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). (from UniProt Q9CPR4) AK011132 ENSMUST00000237431.1 Q6ZWZ7 Q9CPR4 RL17_MOUSE uc294hkv.1 uc294hkv.2 Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Component of the large ribosomal subunit. Cytoplasm Belongs to the universal ribosomal protein uL22 family. cytoplasmic translation structural constituent of ribosome protein binding nucleus ribosome polysome translation large ribosomal subunit cytosolic large ribosomal subunit A band synapse large ribosomal subunit rRNA binding positive regulation of G1/S transition of mitotic cell cycle uc294hkv.1 uc294hkv.2 
ENSMUST00000237433.2 Vmn1r-ps32 ENSMUST00000237433.2 Vmn1r-ps32 (from geneSymbol) ENSMUST00000237433.1 uc294hkx.1 uc294hkx.2 uc294hkx.1 uc294hkx.2 
ENSMUST00000237461.2 Gm50348 ENSMUST00000237461.2 Gm50348 (from geneSymbol) AK036283 ENSMUST00000237461.1 uc294hlz.1 uc294hlz.2 uc294hlz.1 uc294hlz.2 
ENSMUST00000237468.2 Gm32027 ENSMUST00000237468.2 Gm32027 (from geneSymbol) ENSMUST00000237468.1 uc294hmg.1 uc294hmg.2 uc294hmg.1 uc294hmg.2 
ENSMUST00000237486.2 4930484I04Rik ENSMUST00000237486.2 4930484I04Rik (from geneSymbol) AK015622 ENSMUST00000237486.1 uc294hmy.1 uc294hmy.2 uc294hmy.1 uc294hmy.2 
ENSMUST00000237489.3 Gm50162 ENSMUST00000237489.3 Gm50162 (from geneSymbol) ENSMUST00000237489.1 ENSMUST00000237489.2 uc294hnb.1 uc294hnb.2 uc294hnb.3 uc294hnb.1 uc294hnb.2 uc294hnb.3 
ENSMUST00000237491.2 Cyp4f39 ENSMUST00000237491.2 cytochrome P450, family 4, subfamily f, polypeptide 39 (from RefSeq NM_177307.3) Cyp4f39 ENSMUST00000237491.1 NM_177307 Q8BGU0 Q8BGU0_MOUSE uc294hnd.1 uc294hnd.2 Belongs to the cytochrome P450 family. molecular_function monooxygenase activity iron ion binding cellular_component biological_process membrane integral component of membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding oxidation-reduction process uc294hnd.1 uc294hnd.2 
ENSMUST00000237494.2 Gm50108 ENSMUST00000237494.2 Gm50108 (from geneSymbol) ENSMUST00000237494.1 uc294hng.1 uc294hng.2 uc294hng.1 uc294hng.2 
ENSMUST00000237500.4 Gm50370 ENSMUST00000237500.4 Gm50370 (from geneSymbol) ENSMUST00000237500.1 ENSMUST00000237500.2 ENSMUST00000237500.3 uc294hnm.1 uc294hnm.2 uc294hnm.3 uc294hnm.4 uc294hnm.1 uc294hnm.2 uc294hnm.3 uc294hnm.4 
ENSMUST00000237516.2 Gm50337 ENSMUST00000237516.2 Gm50337 (from geneSymbol) ENSMUST00000237516.1 uc294hoa.1 uc294hoa.2 uc294hoa.1 uc294hoa.2 
ENSMUST00000237521.2 Gal ENSMUST00000237521.2 galanin and GMAP prepropeptide, transcript variant 1 (from RefSeq NM_010253.4) ENSMUST00000237521.1 Gal NM_010253 Q3V002 Q3V002_MOUSE uc294hoe.1 uc294hoe.2 This gene encodes a neuroendocrine peptide that is principally produced by a subpopulation of lactotrophs in the pituitary gland. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Mice lacking the encoded protein fail to lactate sufficiently due to abnormalities in the expression of prolactin and lactotroph proliferation, exhibit attenuated chronic neuropathic pain and developmental deficits in the dorsal root ganglion neurons. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature proteins. [provided by RefSeq, Jul 2016]. Secreted Belongs to the galanin family. galanin receptor activity hormone activity neuropeptide hormone activity extracellular region extracellular space cytoplasm Golgi apparatus inflammatory response neuropeptide signaling pathway feeding behavior negative regulation of cell proliferation protein kinase A signaling cAMP-mediated signaling secretory granule type 1 galanin receptor binding type 2 galanin receptor binding type 3 galanin receptor binding regulation of glucocorticoid metabolic process response to insulin response to immobilization stress response to drug neuronal cell body positive regulation of apoptotic process response to estrogen positive regulation of transcription from RNA polymerase II promoter negative regulation of lymphocyte proliferation positive regulation of cortisol secretion positive regulation of catagen positive regulation of large conductance calcium-activated potassium channel activity negative regulation of root hair elongation uc294hoe.1 uc294hoe.2 
ENSMUST00000237522.2 Saxo4 ENSMUST00000237522.2 stabilizer of axonemal microtubules 4, transcript variant 2 (from RefSeq NM_133689.2) A0A0R4J0F3 A0A0R4J0F3_MOUSE ENSMUST00000237522.1 NM_133689 Ppp1r32 Saxo4 uc294hof.1 uc294hof.2 uc294hof.1 uc294hof.2 
ENSMUST00000237525.2 Gm50187 ENSMUST00000237525.2 Gm50187 (from geneSymbol) ENSMUST00000237525.1 uc294hoi.1 uc294hoi.2 uc294hoi.1 uc294hoi.2 
ENSMUST00000237534.2 Gm50226 ENSMUST00000237534.2 Gm50226 (from geneSymbol) ENSMUST00000237534.1 uc294hor.1 uc294hor.2 uc294hor.1 uc294hor.2 
ENSMUST00000237537.2 Gm50218 ENSMUST00000237537.2 Gm50218 (from geneSymbol) ENSMUST00000237537.1 uc294hou.1 uc294hou.2 uc294hou.1 uc294hou.2 
ENSMUST00000237543.3 4930554I06Rik ENSMUST00000237543.3 4930554I06Rik (from geneSymbol) AK016120 ENSMUST00000237543.1 ENSMUST00000237543.2 uc294hpa.1 uc294hpa.2 uc294hpa.3 uc294hpa.1 uc294hpa.2 uc294hpa.3 
ENSMUST00000237546.2 Duox2 ENSMUST00000237546.2 dual oxidase 2 (from RefSeq NM_001362755.1) A0A494BAW1 A0A494BAW1_MOUSE Duox2 ENSMUST00000237546.1 NM_001362755 uc294hpd.1 uc294hpd.2 Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. Reaction=H(+) + NADH + O2 = H2O2 + NAD(+); Xref=Rhea:RHEA:11264, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.3.1; Evidence=; Reaction=H(+) + NADPH + O2 = H2O2 + NADP(+); Xref=Rhea:RHEA:11260, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.6.3.1; Evidence=; Hormone biosynthesis; thyroid hormone biosynthesis. Apical cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein In the N-terminal section; belongs to the peroxidase family. peroxidase activity calcium ion binding endoplasmic reticulum cytosol plasma membrane defense response response to oxidative stress fertilization response to virus cell surface membrane integral component of membrane NAD(P)H oxidase activity superoxide-generating NADPH oxidase activity oxidoreductase activity cytokine-mediated signaling pathway heme binding bone mineralization thyroid gland development cell leading edge multicellular organism growth thyroid hormone metabolic process hormone metabolic process superoxide anion generation NADPH oxidase complex apical part of cell inner ear development adenohypophysis morphogenesis hydrogen peroxide biosynthetic process response to cAMP oxidation-reduction process positive regulation of wound healing cellular oxidant detoxification positive regulation of cell motility uc294hpd.1 uc294hpd.2 
ENSMUST00000237555.2 Gm50330 ENSMUST00000237555.2 Gm50330 (from geneSymbol) ENSMUST00000237555.1 uc294hpk.1 uc294hpk.2 uc294hpk.1 uc294hpk.2 
ENSMUST00000237558.2 G630055G22Rik ENSMUST00000237558.2 RIKEN cDNA G630055G22 gene (from RefSeq NR_045404.1) ENSMUST00000237558.1 NR_045404 uc294hpn.1 uc294hpn.2 uc294hpn.1 uc294hpn.2 
ENSMUST00000237560.2 Vmn1r232 ENSMUST00000237560.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A2RTT5) A2RTT5 A2RTT5_MOUSE ENSMUST00000237560.1 V1re4 Vmn1r232 uc294hpp.1 uc294hpp.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294hpp.1 uc294hpp.2 
ENSMUST00000237569.2 Gm50424 ENSMUST00000237569.2 Gm50424 (from geneSymbol) ENSMUST00000237569.1 uc294hpx.1 uc294hpx.2 uc294hpx.1 uc294hpx.2 
ENSMUST00000237574.2 Gm38695 ENSMUST00000237574.2 predicted gene, 35234 (from RefSeq NR_165277.1) ENSMUST00000237574.1 NR_165277 uc294hqb.1 uc294hqb.2 uc294hqb.1 uc294hqb.2 
ENSMUST00000237584.3 Gm34808 ENSMUST00000237584.3 Gm34808 (from geneSymbol) ENSMUST00000237584.1 ENSMUST00000237584.2 uc294hql.1 uc294hql.2 uc294hql.3 uc294hql.1 uc294hql.2 uc294hql.3 
ENSMUST00000237590.3 ENSMUSG00000121859 ENSMUST00000237590.3 ENSMUSG00000121859 (from geneSymbol) ENSMUST00000237590.1 ENSMUST00000237590.2 uc294hqq.1 uc294hqq.2 uc294hqq.3 uc294hqq.1 uc294hqq.2 uc294hqq.3 
ENSMUST00000237592.2 Snhg4 ENSMUST00000237592.2 Snhg4 (from geneSymbol) A0A494B9X1 A0A494B9X1_MOUSE CT010322 ENSMUST00000237592.1 Snhg4 uc294hqs.1 uc294hqs.2 nucleic acid binding RNA binding uc294hqs.1 uc294hqs.2 
ENSMUST00000237598.2 Gm32548 ENSMUST00000237598.2 predicted gene, 32548 (from RefSeq NR_166872.1) ENSMUST00000237598.1 NR_166872 uc294hqy.1 uc294hqy.2 uc294hqy.1 uc294hqy.2 
ENSMUST00000237599.2 Gm50102 ENSMUST00000237599.2 Gm50102 (from geneSymbol) ENSMUST00000237599.1 uc294hqz.1 uc294hqz.2 uc294hqz.1 uc294hqz.2 
ENSMUST00000237618.2 Gm50430 ENSMUST00000237618.2 Gm50430 (from geneSymbol) ENSMUST00000237618.1 uc294hrp.1 uc294hrp.2 uc294hrp.1 uc294hrp.2 
ENSMUST00000237624.3 Gm41708 ENSMUST00000237624.3 Gm41708 (from geneSymbol) ENSMUST00000237624.1 ENSMUST00000237624.2 uc294hrv.1 uc294hrv.2 uc294hrv.3 uc294hrv.1 uc294hrv.2 uc294hrv.3 
ENSMUST00000237628.2 Gm50333 ENSMUST00000237628.2 Gm50333 (from geneSymbol) ENSMUST00000237628.1 uc294hrz.1 uc294hrz.2 uc294hrz.1 uc294hrz.2 
ENSMUST00000237648.2 Gm31019 ENSMUST00000237648.2 predicted gene, 31019 (from RefSeq NR_188910.1) ENSMUST00000237648.1 NR_188910 uc294hss.1 uc294hss.2 uc294hss.1 uc294hss.2 
ENSMUST00000237651.2 Zfand5 ENSMUST00000237651.2 zinc finger, AN1-type domain 5 (from RefSeq NM_009551.5) ENSMUST00000237651.1 NM_009551 O88878 Q3B7K8 ZFAN5_MOUSE Za20d2 Zfp216 Znf216 uc294hsv.1 uc294hsv.2 Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. Homooligomer and/or heterooligomer. Interacts (via A20-type domain) with IKBKG and RIPK1 and with TRAF6 (via AN1-type domain) (By similarity). Interacts with ubiquitin and polyubiquitinated proteins. Identified in a heterotrimeric complex with ubiquitin and SQSTM1, where ZFAND5 and SQSTM1 both interact with the same ubiquitin molecule (By similarity). Cytoplasm Expressed in brain, muscle, eye, and heart, lower expression in lung, kidney, and spleen, and very low expression in liver. Expressed in myoblast C2C12 cells (at protein level). Up-regulated after TNFSF11 stimulation. Expression also induced by other cytokines such as TNF and IL1B. No significant inhibitory effect on the NF-kappa-B pathway is observed. Expression is increased in both denervation- and fasting-induced muscle atrophy. The A20-type zinc finger directly binds polyubiquitin chains and associates with the 26S proteasome. The zinc-finger A20-type domain is essential for inhibition of NF-kappa-B activation. Resistance to muscle atrophy accompanied by abnormal accumulation of polyubiquitinated proteins in skeletal muscle. in utero embryonic development vasculature development respiratory system process DNA binding cytoplasm zinc ion binding fibroblast migration metal ion binding platelet-derived growth factor receptor signaling pathway skeletal system morphogenesis smooth muscle tissue development face development uc294hsv.1 uc294hsv.2 
ENSMUST00000237654.2 Gm50139 ENSMUST00000237654.2 Gm50139 (from geneSymbol) A0A494BAL6 A0A494BAL6_MOUSE BC152909 ENSMUST00000237654.1 Gm50139 uc294hsy.1 uc294hsy.2 uc294hsy.1 uc294hsy.2 
ENSMUST00000237657.2 Gm50260 ENSMUST00000237657.2 Gm50260 (from geneSymbol) ENSMUST00000237657.1 uc294hta.1 uc294hta.2 uc294hta.1 uc294hta.2 
ENSMUST00000237661.2 Gm50191 ENSMUST00000237661.2 Gm50191 (from geneSymbol) AK139775 ENSMUST00000237661.1 uc294hte.1 uc294hte.2 uc294hte.1 uc294hte.2 
ENSMUST00000237665.3 1810035K13Rik ENSMUST00000237665.3 1810035K13Rik (from geneSymbol) AK019027 ENSMUST00000237665.1 ENSMUST00000237665.2 uc294hti.1 uc294hti.2 uc294hti.3 uc294hti.1 uc294hti.2 uc294hti.3 
ENSMUST00000237666.2 Vmn1r-ps47 ENSMUST00000237666.2 Vmn1r-ps47 (from geneSymbol) ENSMUST00000237666.1 uc294htj.1 uc294htj.2 uc294htj.1 uc294htj.2 
ENSMUST00000237668.2 A530088E08Rik ENSMUST00000237668.2 A530088E08Rik (from geneSymbol) ENSMUST00000237668.1 uc294htl.1 uc294htl.2 uc294htl.1 uc294htl.2 
ENSMUST00000237674.2 Slc14a2 ENSMUST00000237674.2 solute carrier family 14 (urea transporter), member 2, transcript variant 1 (from RefSeq NM_207651.3) ENSMUST00000237674.1 G5E849 G5E849_MOUSE NM_207651 Slc14a2 uc294htr.1 uc294htr.2 Reaction=urea(in) = urea(out); Xref=Rhea:RHEA:32799, ChEBI:CHEBI:16199; Evidence=; Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the urea transporter family. urea transmembrane transporter activity membrane integral component of membrane urea transmembrane transport uc294htr.1 uc294htr.2 
ENSMUST00000237678.2 Gm47071 ENSMUST00000237678.2 Gm47071 (from geneSymbol) AK043531 ENSMUST00000237678.1 uc294htv.1 uc294htv.2 uc294htv.1 uc294htv.2 
ENSMUST00000237690.2 Gm55328 ENSMUST00000237690.2 Gm55328 (from geneSymbol) ENSMUST00000237690.1 LF201822 uc294huh.1 uc294huh.2 uc294huh.1 uc294huh.2 
ENSMUST00000237696.2 Gm50250 ENSMUST00000237696.2 Gm50250 (from geneSymbol) ENSMUST00000237696.1 uc294hun.1 uc294hun.2 uc294hun.1 uc294hun.2 
ENSMUST00000237702.2 Vmn1r-ps24 ENSMUST00000237702.2 Vmn1r-ps24 (from geneSymbol) ENSMUST00000237702.1 uc294hut.1 uc294hut.2 uc294hut.1 uc294hut.2 
ENSMUST00000237729.2 Gm50205 ENSMUST00000237729.2 Gm50205 (from geneSymbol) ENSMUST00000237729.1 uc294hvu.1 uc294hvu.2 uc294hvu.1 uc294hvu.2 
ENSMUST00000237731.2 BC051537 ENSMUST00000237731.2 BC051537 (from geneSymbol) AK136114 ENSMUST00000237731.1 uc294hvw.1 uc294hvw.2 uc294hvw.1 uc294hvw.2 
ENSMUST00000237736.3 Gm41720 ENSMUST00000237736.3 Gm41720 (from geneSymbol) ENSMUST00000237736.1 ENSMUST00000237736.2 uc294hwb.1 uc294hwb.2 uc294hwb.3 uc294hwb.1 uc294hwb.2 uc294hwb.3 
ENSMUST00000237741.2 Gm50167 ENSMUST00000237741.2 Gm50167 (from geneSymbol) ENSMUST00000237741.1 uc294hwg.1 uc294hwg.2 uc294hwg.1 uc294hwg.2 
ENSMUST00000237746.2 Gm50376 ENSMUST00000237746.2 Gm50376 (from geneSymbol) ENSMUST00000237746.1 uc294hwl.1 uc294hwl.2 uc294hwl.1 uc294hwl.2 
ENSMUST00000237753.2 9030625G05Rik ENSMUST00000237753.2 RIKEN cDNA 9030625G05 gene (from RefSeq NR_110446.1) ENSMUST00000237753.1 NR_110446 uc294hws.1 uc294hws.2 uc294hws.1 uc294hws.2 
ENSMUST00000237754.2 Gm50261 ENSMUST00000237754.2 Gm50261 (from geneSymbol) ENSMUST00000237754.1 uc294hwt.1 uc294hwt.2 uc294hwt.1 uc294hwt.2 
ENSMUST00000237758.3 Gm4402 ENSMUST00000237758.3 predicted gene 4402 (from RefSeq NR_188855.1) ENSMUST00000237758.1 ENSMUST00000237758.2 NR_188855 uc294hwx.1 uc294hwx.2 uc294hwx.3 uc294hwx.1 uc294hwx.2 uc294hwx.3 
ENSMUST00000237772.2 Vmn1r62 ENSMUST00000237772.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8R2C0) ENSMUST00000237772.1 Q8R2C0 Q8R2C0_MOUSE V1rd2 V1rd8 Vmn1r62 uc294hxl.1 uc294hxl.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294hxl.1 uc294hxl.2 
ENSMUST00000237782.2 Gm50171 ENSMUST00000237782.2 Gm50171 (from geneSymbol) AK035004 ENSMUST00000237782.1 uc294hxv.1 uc294hxv.2 uc294hxv.1 uc294hxv.2 
ENSMUST00000237783.2 Ndst1 ENSMUST00000237783.2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1, transcript variant 1 (from RefSeq NM_008306.5) ENSMUST00000237783.1 NDST1_MOUSE NM_008306 Ndst1 O70353 Q3TBX3 Q3TDS3 Q3UHN9 Q8BZE5 Q9R206 uc294hxw.1 uc294hxw.2 Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:11087757, PubMed:10758005, PubMed:10664446, PubMed:12590599, PubMed:12692154, PubMed:16020517, PubMed:16056228, PubMed:18337501). Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (Probable). Plays a role in determining the extent and pattern of sulfation of heparan sulfate (Probable). Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (PubMed:16056228). Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Reaction=H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) = acetate + alpha-D-glucosaminyl-[heparan sulfate](n); Xref=Rhea:RHEA:70587, Rhea:RHEA-COMP:9830, Rhea:RHEA-COMP:11585, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:58388, ChEBI:CHEBI:70974; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70588; Evidence=; Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha- D-glucosaminyl-[heparan sulfate](n); Xref=Rhea:RHEA:21980, Rhea:RHEA- COMP:9830, Rhea:RHEA-COMP:14602, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:140572; EC=2.8.2.8; Evidence= PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21981; Evidence=; Inhibited by long N-sulfated sequences (more than 6 sugar residues) accumulating in its substrates heparan sulfate, and heparin. Kinetic parameters: KM=13.3 uM for K5 polysaccharide ; KM=0.35 uM for N-acetylated HS-II ; Glycan metabolism; heparan sulfate biosynthesis. Glycan metabolism; heparin biosynthesis. Monomer (By similarity). Interacts with heparan sulfate co- polymerase subunits EXT1 and EXT2. Q3UHN9; P70428: Ext2; NbExp=2; IntAct=EBI-15693148, EBI-15693102; Golgi apparatus membrane ; Single-pass type II membrane protein Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein Golgi apparatus, cis-Golgi network membrane ; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3UHN9-1; Sequence=Displayed; Name=2; IsoId=Q3UHN9-2; Sequence=VSP_017401, VSP_017402; Name=3; IsoId=Q3UHN9-3; Sequence=VSP_017399, VSP_017400; Widely expressed in adult and throughout development. Mice survive until birth but are cyanotic and die neonatally in a condition resembling respiratory distress syndrome. In addition, a minor proportion of mice embryos die during the embryonic period. Mutant mice display cerebral hypoplasia and craniofacial defects, disturbed Ca(2+) kinetics in myotubes. They also display deficiencies L-selectin and chemokine-mediated neutrophil trafficking during inflammatory responses. The presence of 4 different NDST enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences. Belongs to the sulfotransferase 1 family. NDST subfamily. Sequence=BAE41527.1; Type=Frameshift; Evidence=; Golgi membrane polysaccharide biosynthetic process cardiac septum development catalytic activity protein binding Golgi apparatus protein deacetylation protein sulfation inflammatory response heart development respiratory gaseous exchange sulfotransferase activity metabolic process fibroblast growth factor receptor signaling pathway animal organ morphogenesis heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [heparan sulfate]-glucosamine N-sulfotransferase activity membrane integral component of membrane transferase activity hydrolase activity deacetylase activity glycosaminoglycan metabolic process heparin biosynthetic process forebrain development midbrain development aorta development heparan sulfate N-acetylglucosaminyltransferase activity positive regulation of MAPK cascade positive regulation of smoothened signaling pathway embryonic neurocranium morphogenesis embryonic viscerocranium morphogenesis coronary vasculature development uc294hxw.1 uc294hxw.2 
ENSMUST00000237803.2 Gm50345 ENSMUST00000237803.2 Gm50345 (from geneSymbol) AK155738 ENSMUST00000237803.1 uc294hyq.1 uc294hyq.2 uc294hyq.1 uc294hyq.2 
ENSMUST00000237813.2 Gm50294 ENSMUST00000237813.2 Gm50294 (from geneSymbol) ENSMUST00000237813.1 uc294hza.1 uc294hza.2 uc294hza.1 uc294hza.2 
ENSMUST00000237814.2 Cyb561a3 ENSMUST00000237814.2 cytochrome b561 family, member A3, transcript variant 1 (from RefSeq NM_201351.2) CYAC3_MOUSE Cyb561a3 Cybasc3 ENSMUST00000237814.1 NM_201351 Q3TVE2 Q3V3G2 Q6P1H1 uc294hzb.1 uc294hzb.2 Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome (PubMed:16911521). Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters (Probable). It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis (Probable). Reaction=Fe(3+)(out) + L-ascorbate(in) = Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in); Xref=Rhea:RHEA:30403, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:38290, ChEBI:CHEBI:59513; EC=7.2.1.3; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30404; Evidence=; Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence=; Note=Binds 2 heme b groups non-covalently. ; Homodimer. Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P1H1-1; Sequence=Displayed; Name=2; IsoId=Q6P1H1-2; Sequence=VSP_030398; Name=3; IsoId=Q6P1H1-3; Sequence=VSP_030399; Present in lung, spleen, thymus and testis. Present at low level in brain, heart, liver and kidney. Expressed in the alveolar macrophages of the lung, in the white pulp of the spleen, widespread in the thymus, and in the Sertoli cells of the testis (at protein level). At 17.5 dpc, it is primarily expressed in lung, spleen, thymus, testis, placenta, small intestine and stomach. N-glycosylated. lysosome lysosomal membrane endosome membrane integral component of membrane oxidoreductase activity late endosome membrane metal ion binding oxidation-reduction process uc294hzb.1 uc294hzb.2 
ENSMUST00000237842.3 Gm50361 ENSMUST00000237842.3 Gm50361 (from geneSymbol) ENSMUST00000237842.1 ENSMUST00000237842.2 KY467806 uc294iad.1 uc294iad.2 uc294iad.3 uc294iad.1 uc294iad.2 uc294iad.3 
ENSMUST00000237846.2 Gm50151 ENSMUST00000237846.2 Gm50151 (from geneSymbol) ENSMUST00000237846.1 uc294iah.1 uc294iah.2 uc294iah.1 uc294iah.2 
ENSMUST00000237850.2 A330093E20Rik ENSMUST00000237850.2 RIKEN cDNA A330093E20 gene (from RefSeq NR_040342.1) ENSMUST00000237850.1 NR_040342 uc294ial.1 uc294ial.2 uc294ial.1 uc294ial.2 
ENSMUST00000237857.3 Gm30641 ENSMUST00000237857.3 Gm30641 (from geneSymbol) AK030301 ENSMUST00000237857.1 ENSMUST00000237857.2 uc294ias.1 uc294ias.2 uc294ias.3 uc294ias.1 uc294ias.2 uc294ias.3 
ENSMUST00000237871.2 Tm9sf3 ENSMUST00000237871.2 transmembrane 9 superfamily member 3 (from RefSeq NM_133352.2) ENSMUST00000237871.1 NM_133352 Q9ET30 Smbp TM9S3_MOUSE uc294ibg.1 uc294ibg.2 Membrane ; Multi-pass membrane protein Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. Sequence=AAH04799.2; Type=Erroneous initiation; Evidence=; molecular_function membrane integral component of membrane protein localization to membrane uc294ibg.1 uc294ibg.2 
ENSMUST00000237880.2 Csnk1g3 ENSMUST00000237880.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; (from UniProt A0A494BAP2) A0A494BAP2 A0A494BAP2_MOUSE BC033601 Csnk1g3 ENSMUST00000237880.1 uc294ibp.1 uc294ibp.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Cytoplasm Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding protein phosphorylation uc294ibp.1 uc294ibp.2 
ENSMUST00000237883.2 Vmn1r-ps15 ENSMUST00000237883.2 Vmn1r-ps15 (from geneSymbol) ENSMUST00000237883.1 uc294ibs.1 uc294ibs.2 uc294ibs.1 uc294ibs.2 
ENSMUST00000237889.2 Umodl1 ENSMUST00000237889.2 Cell membrane ; Single-pass type I membrane protein (from UniProt Q5DID3) AY771616 ENSMUST00000237889.1 Q5DID1 Q5DID2 Q5DID3 UROL1_MOUSE uc294iby.1 uc294iby.2 Cell membrane ; Single-pass type I membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5DID3-1; Sequence=Displayed; Name=2; IsoId=Q5DID3-2; Sequence=VSP_017661; Name=3; IsoId=Q5DID3-3; Sequence=VSP_017660; First detected at 16.5 dpc only in olfactory epithelium (OE) and the epithelium of the vomeronasal organ (VNO). At this stage, expression in OE is punctate and is restricted to only some of the sensory neurons. At birth and postnatally, expression in these organs extends to more neurons. At 3 weeks, expression shows a smooth gradation from high apical to low basal within the layer of mature olfactory sensory neurons of the olfactory epithelium. calcium ion binding extracellular region extracellular space plasma membrane single fertilization external side of plasma membrane negative regulation of peptidase activity regulation of gene expression membrane integral component of membrane peptidase inhibitor activity regulation of apoptotic process multicellular organismal reproductive process adipose tissue development cellular response to gonadotropin-releasing hormone regulation of ovarian follicle development uc294iby.1 uc294iby.2 
ENSMUST00000237890.2 Gm50378 ENSMUST00000237890.2 Gm50378 (from geneSymbol) ENSMUST00000237890.1 uc294ibz.1 uc294ibz.2 uc294ibz.1 uc294ibz.2 
ENSMUST00000237899.3 Gm50275 ENSMUST00000237899.3 Gm50275 (from geneSymbol) ENSMUST00000237899.1 ENSMUST00000237899.2 uc294ici.1 uc294ici.2 uc294ici.3 uc294ici.1 uc294ici.2 uc294ici.3 
ENSMUST00000237906.2 Gm50315 ENSMUST00000237906.2 Gm50315 (from geneSymbol) ENSMUST00000237906.1 uc294icp.1 uc294icp.2 uc294icp.1 uc294icp.2 
ENSMUST00000237934.2 Gpr137 ENSMUST00000237934.2 Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. (from UniProt Q80ZU9) BC048078 ENSMUST00000237934.1 G137A_MOUSE Q80UB6 Q80ZU9 Tm7sf1l1 uc294idq.1 uc294idq.2 Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. May activate Wnt/beta-catenin signaling to modulate epithelial cell function. Lysosome membrane ; Multi-pass membrane protein Belongs to the GPR137 family. molecular_function cellular_component biological_process membrane integral component of membrane uc294idq.1 uc294idq.2 
ENSMUST00000237947.2 Gm50462 ENSMUST00000237947.2 Gm50462 (from geneSymbol) AB345030 ENSMUST00000237947.1 uc294iec.1 uc294iec.2 uc294iec.1 uc294iec.2 
ENSMUST00000237954.3 9330117O12Rik ENSMUST00000237954.3 RIKEN cDNA 9330117O12 gene (from RefSeq NR_045400.1) ENSMUST00000237954.1 ENSMUST00000237954.2 NR_045400 uc294iej.1 uc294iej.2 uc294iej.3 uc294iej.1 uc294iej.2 uc294iej.3 
ENSMUST00000237957.2 Gm36419 ENSMUST00000237957.2 Gm36419 (from geneSymbol) ENSMUST00000237957.1 uc294iem.1 uc294iem.2 uc294iem.1 uc294iem.2 
ENSMUST00000237961.3 Gm50202 ENSMUST00000237961.3 Gm50202 (from geneSymbol) ENSMUST00000237961.1 ENSMUST00000237961.2 uc294ieq.1 uc294ieq.2 uc294ieq.3 uc294ieq.1 uc294ieq.2 uc294ieq.3 
ENSMUST00000237966.2 Gm50346 ENSMUST00000237966.2 Gm50346 (from geneSymbol) AK155402 ENSMUST00000237966.1 uc294iev.1 uc294iev.2 uc294iev.1 uc294iev.2 
ENSMUST00000237969.2 Gm50353 ENSMUST00000237969.2 Gm50353 (from geneSymbol) ENSMUST00000237969.1 uc294iey.1 uc294iey.2 uc294iey.1 uc294iey.2 
ENSMUST00000238002.2 Vmn1r223 ENSMUST00000238002.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q5SSA0) ENSMUST00000238002.1 Q5SSA0 Q5SSA0_MOUSE Vmn1r223 uc294igf.1 uc294igf.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294igf.1 uc294igf.2 
ENSMUST00000238018.2 Gm50284 ENSMUST00000238018.2 Gm50284 (from geneSymbol) ENSMUST00000238018.1 uc294igv.1 uc294igv.2 uc294igv.1 uc294igv.2 
ENSMUST00000238019.2 Gm50299 ENSMUST00000238019.2 Gm50299 (from geneSymbol) ENSMUST00000238019.1 uc294igw.1 uc294igw.2 uc294igw.1 uc294igw.2 
ENSMUST00000238022.2 Gm31706 ENSMUST00000238022.2 Gm31706 (from geneSymbol) AK148773 ENSMUST00000238022.1 uc294igz.1 uc294igz.2 uc294igz.1 uc294igz.2 
ENSMUST00000238024.2 BC026513 ENSMUST00000238024.2 cDNA sequence BC026513, transcript variant 1 (from RefSeq NR_188715.1) ENSMUST00000238024.1 NR_188715 uc294ihb.1 uc294ihb.2 uc294ihb.1 uc294ihb.2 
ENSMUST00000238029.4 8030456M14Rik ENSMUST00000238029.4 8030456M14Rik (from geneSymbol) AK020210 ENSMUST00000238029.1 ENSMUST00000238029.2 ENSMUST00000238029.3 uc294ihg.1 uc294ihg.2 uc294ihg.3 uc294ihg.4 uc294ihg.1 uc294ihg.2 uc294ihg.3 uc294ihg.4 
ENSMUST00000238036.2 Ubxn1 ENSMUST00000238036.2 Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1. Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF- kappa-B. Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. (from UniProt Q922Y1) AK015468 D19Ertd721e ENSMUST00000238036.1 Q3UCP8 Q922Y1 Saks1 UBXN1_MOUSE uc294ihm.1 uc294ihm.2 Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1. Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF- kappa-B. Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Interacts with MAVS; this interaction prevents MAVS oligomerization and thus disrupts the RLR signaling pathway. Interacts with CUL1; this interaction inhibits CUL1-mediated degradation of NF- kappa-B inhibitors. Interacts with BIRC2/c-IAP1; this interaction prevents TNFalpha-stimulated RIP1 ubiquitination and subsequent NF- kappa-B activation. Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B (PubMed:11562482). Interacts with HOMER2 (PubMed:16709668). Interacts directly with VCP. Interacts with BRCA1 and BARD1; interaction takes place when BRCA1 is not autoubiquitinated but is strongly enhanced in the presence of autoubiquitinated BRCA1. Cytoplasm The UBA domain specifically recognizes and binds 'Lys-6'-linked polyubiquitin chains. nucleus cytoplasm endoplasmic reticulum cytosol dendrite negative regulation of protein ubiquitination polyubiquitin binding ubiquitin protein ligase binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process VCP-NPL4-UFD1 AAA ATPase complex K48-linked polyubiquitin binding neuronal cell body ubiquitin binding ATPase binding K6-linked polyubiquitin binding negative regulation of protein K48-linked deubiquitination negative regulation of ERAD pathway proteasome regulatory particle binding negative regulation of ubiquitin-specific protease activity uc294ihm.1 uc294ihm.2 
ENSMUST00000238050.3 Gm50149 ENSMUST00000238050.3 Gm50149 (from geneSymbol) ENSMUST00000238050.1 ENSMUST00000238050.2 uc294iia.1 uc294iia.2 uc294iia.3 uc294iia.1 uc294iia.2 uc294iia.3 
ENSMUST00000238052.3 Gm50334 ENSMUST00000238052.3 Gm50334 (from geneSymbol) ENSMUST00000238052.1 ENSMUST00000238052.2 uc294iic.1 uc294iic.2 uc294iic.3 uc294iic.1 uc294iic.2 uc294iic.3 
ENSMUST00000238056.3 Gm50182 ENSMUST00000238056.3 Gm50182 (from geneSymbol) ENSMUST00000238056.1 ENSMUST00000238056.2 uc294iig.1 uc294iig.2 uc294iig.3 uc294iig.1 uc294iig.2 uc294iig.3 
ENSMUST00000238064.2 Gm50311 ENSMUST00000238064.2 Gm50311 (from geneSymbol) ENSMUST00000238064.1 uc294iio.1 uc294iio.2 uc294iio.1 uc294iio.2 
ENSMUST00000238080.2 Gm7276 ENSMUST00000238080.2 Gm7276 (from geneSymbol) AK158289 ENSMUST00000238080.1 uc294ije.1 uc294ije.2 uc294ije.1 uc294ije.2 
ENSMUST00000238081.2 Htr4 ENSMUST00000238081.2 5 hydroxytryptamine (serotonin) receptor 4, transcript variant 3 (from RefSeq NM_001364957.1) 5HT4R_MOUSE ENSMUST00000238081.1 NM_001364957 O89003 O89004 P97288 Q3URB5 Q9R2A4 uc294ijf.1 uc294ijf.2 This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (By similarity). Isoform 5-HT4(A) interacts with MAGI2, MPP3, NHERF1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with PATJ, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including NHERF1 and EZR. Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin) (By similarity). P97288; P34947: GRK5; Xeno; NbExp=8; IntAct=EBI-7149283, EBI-7149314; P97288; P12931: SRC; Xeno; NbExp=2; IntAct=EBI-7149283, EBI-621482; Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with NHERF1 and EZR might target the protein to specialized subcellular regions, such as microvilli. Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P97288-1; Sequence=Displayed; Name=5-HT4(A); IsoId=P97288-2; Sequence=VSP_001851; Name=5-HT4(E); IsoId=P97288-3; Sequence=VSP_001852; Name=5-HT4(F); IsoId=P97288-4; Sequence=VSP_001853; Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity G-protein coupled serotonin receptor activity protein binding cytoplasm endosome plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating G-protein coupled receptor signaling pathway gamma-aminobutyric acid signaling pathway chemical synaptic transmission membrane integral component of membrane dendrite neurotransmitter receptor activity regulation of appetite uc294ijf.1 uc294ijf.2 
ENSMUST00000238096.2 Vmn1r231 ENSMUST00000238096.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A494B9X8) A0A494B9X8 A0A494B9X8_MOUSE ENSMUST00000238096.1 Vmn1r231 uc294iju.1 uc294iju.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294iju.1 uc294iju.2 
ENSMUST00000238101.2 Gm50437 ENSMUST00000238101.2 Gm50437 (from geneSymbol) ENSMUST00000238101.1 uc294ijz.1 uc294ijz.2 uc294ijz.1 uc294ijz.2 
ENSMUST00000238103.2 Gm50309 ENSMUST00000238103.2 Gm50309 (from geneSymbol) ENSMUST00000238103.1 uc294ikb.1 uc294ikb.2 uc294ikb.1 uc294ikb.2 
ENSMUST00000238109.2 Vmn1r192 ENSMUST00000238109.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt Q8K4C9) ENSMUST00000238109.1 Q8K4C9 Q8K4C9_MOUSE V1ri1 Vmn1r192 uc294ikh.1 uc294ikh.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. Lacks conserved residue(s) required for the propagation of feature annotation. G-protein coupled receptor activity pheromone binding plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway membrane integral component of membrane pheromone receptor activity response to pheromone uc294ikh.1 uc294ikh.2 
ENSMUST00000238114.2 Gm50446 ENSMUST00000238114.2 Gm50446 (from geneSymbol) ENSMUST00000238114.1 uc294ikm.1 uc294ikm.2 uc294ikm.1 uc294ikm.2 
ENSMUST00000238120.2 Msln ENSMUST00000238120.2 mesothelin, transcript variant 2 (from RefSeq NM_018857.2) ENSMUST00000238120.1 MSLN_MOUSE Mes Mpf NM_018857 Q61468 uc294iks.1 uc294iks.2 Membrane-anchored forms may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) may potentiate megakaryocyte colony formation. Interacts with MUC16. Cell membrane ; Lipid-anchor, GPI- anchor Golgi apparatus [Megakaryocyte-potentiating factor]: Secreted Highly expressed in lung and heart. Expressed at low levels in spleen, liver, kidney and testis. Present in lung (at protein level). Expressed at 7 dpc, down-regulated at 11 dpc, re- expressed at 15 dpc and peaks at 17 dpc. Present in embryonic diaphragm (at protein level). By WNT1 but not by WNT5A in mammary epithelial cells. Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin. Mice have normal growth and reproductive function, and normal platelet counts. Belongs to the mesothelin family. protein binding extracellular region extracellular space Golgi apparatus plasma membrane cell adhesion cell-matrix adhesion cell surface membrane anchored component of membrane uc294iks.1 uc294iks.2 
ENSMUST00000238123.2 Gm50268 ENSMUST00000238123.2 Gm50268 (from geneSymbol) ENSMUST00000238123.1 uc294ikv.1 uc294ikv.2 uc294ikv.1 uc294ikv.2 
ENSMUST00000238131.2 Gm36602 ENSMUST00000238131.2 Gm36602 (from geneSymbol) ENSMUST00000238131.1 uc294ild.1 uc294ild.2 uc294ild.1 uc294ild.2 
ENSMUST00000238137.2 Ankrd2 ENSMUST00000238137.2 ankyrin repeat domain 2 (from RefSeq NM_020033.2) A0A494B9J0 A0A494B9J0_MOUSE Ankrd2 ENSMUST00000238137.1 NM_020033 uc294ilj.1 uc294ilj.2 uc294ilj.1 uc294ilj.2 
ENSMUST00000238142.2 ENSMUSG00000121667 ENSMUST00000238142.2 ENSMUSG00000121667 (from geneSymbol) ENSMUST00000238142.1 uc294ilo.1 uc294ilo.2 uc294ilo.1 uc294ilo.2 
ENSMUST00000238165.4 BC037704 ENSMUST00000238165.4 BC037704 (from geneSymbol) AK140478 ENSMUST00000238165.1 ENSMUST00000238165.2 ENSMUST00000238165.3 uc294imj.1 uc294imj.2 uc294imj.3 uc294imj.4 uc294imj.1 uc294imj.2 uc294imj.3 uc294imj.4 
ENSMUST00000238186.2 Gm10549 ENSMUST00000238186.2 predicted gene 10549 (from RefSeq NR_045415.1) ENSMUST00000238186.1 NR_045415 uc294inc.1 uc294inc.2 uc294inc.1 uc294inc.2 
ENSMUST00000238192.2 Hsf2bp ENSMUST00000238192.2 Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (PubMed:31242413, PubMed:32345962, PubMed:32463460, PubMed:30760716). Required for proper recombinase recruitment in female meiosis (PubMed:30760716, PubMed:32845237). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (PubMed:23707421). May be involved in modulating HSF2 activation in testis (By similarity). (from UniProt Q9D4G2) AK016553 ENSMUST00000238192.1 HSF2B_MOUSE Hsf2bp Meilb2 Q9D4G2 uc294ini.1 uc294ini.2 Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (PubMed:31242413, PubMed:32345962, PubMed:32463460, PubMed:30760716). Required for proper recombinase recruitment in female meiosis (PubMed:30760716, PubMed:32845237). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (PubMed:23707421). May be involved in modulating HSF2 activation in testis (By similarity). Interacts (via C-terminus) with BNC1 (PubMed:23707421). Associates with HSF2. The interaction seems to occur between the trimerization domain of HSF2 and the N-terminal hydrophilic region of HSF2BP (By similarity). Interacts (via N-terminus) with BRME1 (PubMed:32463460, PubMed:32460033, PubMed:32345962). Interacts with BRCA2 and BRME1; the interactions are direct and allow the formation of a ternary complex (PubMed:32345962, PubMed:32460033, PubMed:32463460, PubMed:31242413, PubMed:30760716, PubMed:32845237). The complex BRME1:HSF2BP:BRCA2 interacts with SPATA22, MEIOB and RAD51 (PubMed:32345962, PubMed:30760716). Q9D4G2; O35914: Bnc1; NbExp=4; IntAct=EBI-8527688, EBI-8527667; Cytoplasm romosome Note=Localizes on double-strand breaks (DSBs) in mitotic and meiotic chromosomes. Expressed in testis and, to a lesser extent, in lung and muscle. Detected at low levels from birth to 3 days post partum, thereafter the expression level increases from 5 days post partum to adult. In spermatocytes, shows punctate localization along chromosome axes specifically in early meiotic prophase I cells. Foci start to appear from the leptotene stage, reach their greatest number in the zygotene stage, persist until the early pachytene stage, and finally disappear in the late pachytene stage (PubMed:30760716). Sumoylated by UBE2I in response to MEKK1-mediated stimuli. Male mutants are infertile (PubMed:31242413, PubMed:30760716). They have smaller-than-normal testes with no sperm (PubMed:31242413, PubMed:30760716). Female mutants exhibit a fertility with 40% reduction in litter size compared to wild-type females. They show reduced follicle formation (PubMed:30760716, PubMed:32845237). Mutant oocytes show a delay in prophase I progression with the majority of cells at zygotene stage in 17.5 days post-coitum (dpc) females (PubMed:32845237). protein binding cytoplasm uc294ini.1 uc294ini.2 
ENSMUST00000238197.2 Gm10762 ENSMUST00000238197.2 Gm10762 (from geneSymbol) AK012372 ENSMUST00000238197.1 uc294inn.1 uc294inn.2 uc294inn.1 uc294inn.2 
ENSMUST00000238203.2 Gm21953 ENSMUST00000238203.2 predicted gene, 21953 (from RefSeq NM_001177580.1) A2APU9 A2APU9_MOUSE ENSMUST00000238203.1 F6T205 Gm20878 Gm21586 Gm21953 NM_001177580 uc294int.1 uc294int.2 uc294int.1 uc294int.2 
ENSMUST00000238209.2 Spin2f ENSMUST00000238209.2 Belongs to the SPIN/STSY family. (from UniProt A0A571BGB0) A0A571BGB0 A0A571BGB0_MOUSE ENSMUST00000238209.1 Spin2f uc294inz.1 uc294inz.2 Belongs to the SPIN/STSY family. uc294inz.1 uc294inz.2 
ENSMUST00000238212.2 Dnah7b ENSMUST00000238212.2 dynein, axonemal, heavy chain 7B (from RefSeq NM_001368717.1) A0A571BD48 A0A571BD48_MOUSE Dnah7b ENSMUST00000238212.1 NM_001368717 uc294ioc.1 uc294ioc.2 Belongs to the dynein heavy chain family. uc294ioc.1 uc294ioc.2 
ENSMUST00000238215.3 A730061H03Rik ENSMUST00000238215.3 A730061H03Rik (from geneSymbol) AK049078 ENSMUST00000238215.1 ENSMUST00000238215.2 uc294ioe.1 uc294ioe.2 uc294ioe.3 uc294ioe.1 uc294ioe.2 uc294ioe.3 
ENSMUST00000238218.3 Gm41381 ENSMUST00000238218.3 Gm41381 (from geneSymbol) ENSMUST00000238218.1 ENSMUST00000238218.2 uc294ioh.1 uc294ioh.2 uc294ioh.3 uc294ioh.1 uc294ioh.2 uc294ioh.3 
ENSMUST00000238221.2 Krtap13-23 ENSMUST00000238221.2 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. (from UniProt A0A571BEP9) A0A571BEP9 A0A571BEP9_MOUSE ENSMUST00000238221.1 Gm5965 uc294iok.1 uc294iok.2 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Interacts with hair keratins. Belongs to the PMG family. uc294iok.1 uc294iok.2 
ENSMUST00000238230.2 Zfp1001 ENSMUST00000238230.2 zinc finger protein 1001 (from RefSeq NM_001374676.1) A0A571BEN2 A0A571BEN2_MOUSE ENSMUST00000238230.1 Gm10130 NM_001374676 Zfp1001 uc294ioq.1 uc294ioq.2 Belongs to the krueppel C2H2-type zinc-finger protein family. uc294ioq.1 uc294ioq.2 
ENSMUST00000238237.2 Btbd35f1 ENSMUST00000238237.2 BTB domain containing 35, family member 1 (from RefSeq NM_027955.3) A0A571BEF3 A0A571BEF3_MOUSE Btbd35f1 ENSMUST00000238237.1 NM_027955 uc294iov.1 uc294iov.2 uc294iov.1 uc294iov.2 
ENSMUST00000238243.2 Gm17467 ENSMUST00000238243.2 Gm17467 (from geneSymbol) ENSMUST00000238243.1 FJ386434 uc294ipb.1 uc294ipb.2 uc294ipb.1 uc294ipb.2 
ENSMUST00000238244.2 ENSMUSG00000121620 ENSMUST00000238244.2 ENSMUSG00000121620 (from geneSymbol) ENSMUST00000238244.1 uc294ipc.1 uc294ipc.2 uc294ipc.1 uc294ipc.2 
ENSMUST00000238256.3 4930519P11Rik ENSMUST00000238256.3 4930519P11Rik (from geneSymbol) AK015848 ENSMUST00000238256.1 ENSMUST00000238256.2 uc294ipm.1 uc294ipm.2 uc294ipm.3 uc294ipm.1 uc294ipm.2 uc294ipm.3 
ENSMUST00000238260.3 Gm17334 ENSMUST00000238260.3 Gm17334 (from geneSymbol) ENSMUST00000238260.1 ENSMUST00000238260.2 uc294ipp.1 uc294ipp.2 uc294ipp.1 uc294ipp.2 
ENSMUST00000238266.2 Gm17521 ENSMUST00000238266.2 Gm17521 (from geneSymbol) ENSMUST00000238266.1 uc294ipu.1 uc294ipu.2 uc294ipu.1 uc294ipu.2 
ENSMUST00000238269.2 Gm21616 ENSMUST00000238269.2 Gm21616 (from geneSymbol) ENSMUST00000238269.1 FJ386433 uc294ipx.1 uc294ipx.2 uc294ipx.1 uc294ipx.2 
ENSMUST00000238270.2 Btbd35f8 ENSMUST00000238270.2 Btbd35f8 (from geneSymbol) A0A571BG86 A0A571BG86_MOUSE AK006065 Btbd35f8 ENSMUST00000238270.1 uc294ipy.1 uc294ipy.2 uc294ipy.1 uc294ipy.2 
ENSMUST00000238273.3 Ankfn1 ENSMUST00000238273.3 May play a role in neuronal function. (from UniProt A0A571BF63) A0A571BF63 ANKF1_MOUSE Ankfn1 BC152843 ENSMUST00000238273.1 ENSMUST00000238273.2 Nmf9 mWake uc294iqb.1 uc294iqb.2 May play a role in neuronal function. Expressed in both the suprachiasmatic nucleus and dorsal medial hypothalamus. ENU-induced null mutation in mice produce several neurological abnormalities, including deficits in vestibular function, fear learning and circadian behavior. uc294iqb.1 uc294iqb.2 
ENSMUST00000238276.2 Gm9887 ENSMUST00000238276.2 Gm9887 (from geneSymbol) AK015077 ENSMUST00000238276.1 uc294iqe.1 uc294iqe.2 uc294iqe.1 uc294iqe.2 
ENSMUST00000238281.2 Gm10322 ENSMUST00000238281.2 Gm10322 (from geneSymbol) AK080263 ENSMUST00000238281.1 uc294iqj.1 uc294iqj.2 uc294iqj.1 uc294iqj.2 
ENSMUST00000238282.2 Gm17577 ENSMUST00000238282.2 Gm17577 (from geneSymbol) ENSMUST00000238282.1 FJ386434 uc294iqk.1 uc294iqk.2 uc294iqk.1 uc294iqk.2 
ENSMUST00000238285.3 3110070M22Rik ENSMUST00000238285.3 3110070M22Rik (from geneSymbol) BC050963 ENSMUST00000238285.1 ENSMUST00000238285.2 uc294iqn.1 uc294iqn.2 uc294iqn.3 uc294iqn.1 uc294iqn.2 uc294iqn.3 
ENSMUST00000238289.2 Gpr52 ENSMUST00000238289.2 G protein-coupled receptor 52, transcript variant 2 (from RefSeq NM_001368668.1) ENSMUST00000238289.1 GPR52_MOUSE Gpr52 NM_001368668 P0C5J4 uc294iqr.1 uc294iqr.2 G- protein coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (By similarity). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241, PubMed:28583861). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). Cell membrane; Multi-pass membrane protein. Expressed in brain, especially in striatum (PubMed:24587241). Expressed in the striatum, nucleus accumbens, and lateral globus pallidus (PubMed:28583861). Gpr52 knockout mice are normal in body and brain weight. In the open field test, mice stay and move around the central zone significantly longer. The total distance traveled and brain morphology are normal. Mice are much more sensitive to the startle response following dizocilpine administration. Thus mice displayed psychosis-related behaviors (PubMed:24587241). Mice exhibit a significantly higher istradefylline-induced locomotor activity (PubMed:28583861). GPR52 is located within an intron of RABGAP1L gene, which exhibits epistatic effects on GPR52-mediated modulation of HTT levels by blocking this modulation. Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G-protein coupled receptor signaling pathway phototransduction locomotory behavior G-protein coupled photoreceptor activity detection of visible light membrane integral component of membrane response to drug cellular response to light stimulus uc294iqr.1 uc294iqr.2 
ENSMUST00000238292.2 Zfp869 ENSMUST00000238292.2 zinc finger protein 869, transcript variant 3 (from RefSeq NM_181274.4) ENSMUST00000238292.1 NM_181274 Q9DC47 Q9DC47_MOUSE Zfp869 uc294iqu.1 uc294iqu.2 nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated metal ion binding negative regulation of transposon integration uc294iqu.1 uc294iqu.2 
ENSMUST00000238297.2 Gm9944 ENSMUST00000238297.2 Gm9944 (from geneSymbol) ENSMUST00000238297.1 uc294iqz.1 uc294iqz.2 uc294iqz.1 uc294iqz.2 
ENSMUST00000238299.2 Gm50486 ENSMUST00000238299.2 Gm50486 (from geneSymbol) ENSMUST00000238299.1 uc294ira.1 uc294ira.2 uc294ira.1 uc294ira.2 
ENSMUST00000238302.2 Gm17693 ENSMUST00000238302.2 Gm17693 (from geneSymbol) ENSMUST00000238302.1 FJ386433 uc294ird.1 uc294ird.2 uc294ird.1 uc294ird.2 
ENSMUST00000238307.3 Gm9936 ENSMUST00000238307.3 predicted gene 9936 (from RefSeq NR_164348.1) ENSMUST00000238307.1 ENSMUST00000238307.2 NR_164348 uc294iri.1 uc294iri.2 uc294iri.3 uc294iri.1 uc294iri.2 uc294iri.3 
ENSMUST00000238308.2 Gm9922 ENSMUST00000238308.2 predicted gene 9922 (from RefSeq NR_168926.1) ENSMUST00000238308.1 NR_168926 uc294irj.1 uc294irj.2 uc294irj.1 uc294irj.2 
ENSMUST00000238317.3 Lrrc7 ENSMUST00000238317.3 leucine rich repeat containing 7, transcript variant 5 (from RefSeq NM_001370782.1) A0A571BEA5 A0A571BEA5_MOUSE ENSMUST00000238317.1 ENSMUST00000238317.2 Lrrc7 NM_001370782 uc294irr.1 uc294irr.2 Belongs to the LAP (LRR and PDZ) protein family. uc294irr.1 uc294irr.2 
ENSMUST00000238322.2 Gm10577 ENSMUST00000238322.2 Gm10577 (from geneSymbol) AK149896 ENSMUST00000238322.1 uc294irw.1 uc294irw.2 uc294irw.1 uc294irw.2 
ENSMUST00000238326.2 Gm17469 ENSMUST00000238326.2 Gm17469 (from geneSymbol) ENSMUST00000238326.1 FJ386434 uc294iry.1 uc294iry.2 uc294iry.1 uc294iry.2 
ENSMUST00000238327.2 9330161L09Rik ENSMUST00000238327.2 9330161L09Rik (from geneSymbol) AK020378 ENSMUST00000238327.1 uc294irz.1 uc294irz.2 uc294irz.1 uc294irz.2 
ENSMUST00000238328.2 Gm21586 ENSMUST00000238328.2 predicted gene, 21586 (from RefSeq NM_001270432.2) A2APU9 A2APU9_MOUSE ENSMUST00000238328.1 F6T205 Gm20878 Gm21586 Gm21953 NM_001270432 uc294isa.1 uc294isa.2 uc294isa.1 uc294isa.2 
ENSMUST00000238329.2 Iqcf6 ENSMUST00000238329.2 IQ motif containing F6 (from RefSeq NM_001101628.2) A0A571BFV9 A0A571BFV9_MOUSE ENSMUST00000238329.1 Iqcf6 NM_001101628 uc294isb.1 uc294isb.2 uc294isb.1 uc294isb.2 
ENSMUST00000238331.2 Sh3d19 ENSMUST00000238331.2 May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). (from UniProt Q91X43) D89677 ENSMUST00000238331.1 O08635 O35146 Q8C7I2 Q91X43 SH319_MOUSE uc294isc.1 uc294isc.2 May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Interacts with ADAM12. Isoform 2 (but not isoform 1) interacts with ADAM9, ADAM10, ADAM15 and ADAM17. Interacts with SH3GL1 SH3 domain. Interacts via SH3 3 and SH3 4 or SH3 4 and SH3 5 domains with SOS2. Probably forms a trimeric complex with SH3GL1 and SOS2 (By similarity). Interacts with SH3YL1. Q91X43; O08641: Sh3yl1; NbExp=3; IntAct=EBI-2024543, EBI-2024519; Cytoplasm Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91X43-1; Sequence=Displayed; Name=2; IsoId=Q91X43-2; Sequence=VSP_031185; Expressed in hair follicles. It is uncertain whether Met-1 or Met-4 is the initiator. Sequence=AAB82091.1; Type=Miscellaneous discrepancy; Note=Sequence contamination. Potential vector sequence.; Evidence=; Sequence=AAH12633.1; Type=Miscellaneous discrepancy; Note=Sequence contamination. Potential vector sequence.; Evidence=; Sequence=AAH31117.1; Type=Erroneous initiation; Evidence=; protein binding nucleoplasm cytoplasm cytosol plasma membrane cytoskeleton organization regulation of cell morphogenesis positive regulation of membrane protein ectodomain proteolysis proline-rich region binding uc294isc.1 uc294isc.2 
ENSMUST00000238340.2 Gm10638 ENSMUST00000238340.2 Gm10638 (from geneSymbol) ENSMUST00000238340.1 LF197111 uc294isl.1 uc294isl.2 uc294isl.1 uc294isl.2 
ENSMUST00000238347.2 Prr33 ENSMUST00000238347.2 proline rich 33, transcript variant 1 (from RefSeq NM_001395386.1) A0A571BD03 A0A571BD03_MOUSE ENSMUST00000238347.1 NM_001395386 Prr33 uc294iss.1 uc294iss.2 uc294iss.1 uc294iss.2 
ENSMUST00000238356.2 Gm9821 ENSMUST00000238356.2 Gm9821 (from geneSymbol) ENSMUST00000238356.1 uc294ita.1 uc294ita.2 uc294ita.1 uc294ita.2 
ENSMUST00000238370.3 AW011738 ENSMUST00000238370.3 AW011738 (from geneSymbol) AK044300 ENSMUST00000238370.1 ENSMUST00000238370.2 uc294itn.1 uc294itn.2 uc294itn.3 uc294itn.1 uc294itn.2 uc294itn.3 
ENSMUST00000238379.3 C130032M10Rik ENSMUST00000238379.3 C130032M10Rik (from geneSymbol) AK048065 ENSMUST00000238379.1 ENSMUST00000238379.2 uc294itv.1 uc294itv.2 uc294itv.3 uc294itv.1 uc294itv.2 uc294itv.3 
ENSMUST00000238394.2 ENSMUSG00000121457 ENSMUST00000238394.2 ENSMUSG00000121457 (from geneSymbol) AK006024 ENSMUST00000238394.1 uc294iug.1 uc294iug.2 uc294iug.1 uc294iug.2 
ENSMUST00000238396.2 Gm50469 ENSMUST00000238396.2 Gm50469 (from geneSymbol) ENSMUST00000238396.1 uc294iui.1 uc294iui.2 uc294iui.1 uc294iui.2 
ENSMUST00000238402.2 Mroh5 ENSMUST00000238402.2 Mroh5 (from geneSymbol) A0A571BEG0 A0A571BEG0_MOUSE ENSMUST00000238402.1 Mroh5 NM_001428951 uc294iun.1 uc294iun.2 uc294iun.1 uc294iun.2 
ENSMUST00000238407.2 Wdr88 ENSMUST00000238407.2 WD repeat domain 88 (from RefSeq NM_001370886.1) A0A571BF50 A0A571BF50_MOUSE ENSMUST00000238407.1 NM_001370886 Wdr88 uc294ius.1 uc294ius.2 uc294ius.1 uc294ius.2 
ENSMUST00000238410.3 Cldn34c6 ENSMUST00000238410.3 Cell junction, tight junction (from UniProt A0A571BDF8) A0A571BDF8 A0A571BDF8_MOUSE Cldn34c6 ENSMUST00000238410.1 ENSMUST00000238410.2 Gm2411 uc294iuv.1 uc294iuv.2 uc294iuv.3 Cell junction, tight junction Belongs to the claudin family. uc294iuv.1 uc294iuv.2 uc294iuv.3 
ENSMUST00000238412.3 Dnah14 ENSMUST00000238412.3 dynein, axonemal, heavy chain 14 (from RefSeq NM_001377039.1) A0A571BGC3 A0A571BGC3_MOUSE Dnah14 ENSMUST00000238412.1 ENSMUST00000238412.2 NM_001377039 uc294iux.1 uc294iux.2 Belongs to the dynein heavy chain family. uc294iux.1 uc294iux.2 
ENSMUST00000238415.2 Atp10b ENSMUST00000238415.2 Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence= (from UniProt A0A571BEJ2) A0A571BEJ2 A0A571BEJ2_MOUSE AK220352 Atp10b ENSMUST00000238415.1 uc294iva.1 uc294iva.2 Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence= Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Membrane ulti-pass membrane protein Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. uc294iva.1 uc294iva.2 
ENSMUST00000238426.2 Btbd35f19 ENSMUST00000238426.2 Btbd35f19 (from geneSymbol) A2CG71 A2CG71_MOUSE Btbd35f19 Btbd35f20 ENSMUST00000238426.1 uc294ivk.1 uc294ivk.2 molecular_function cellular_component biological_process uc294ivk.1 uc294ivk.2 
ENSMUST00000238444.2 Gm50467 ENSMUST00000238444.2 Gm50467 (from geneSymbol) ENSMUST00000238444.1 uc294iwb.1 uc294iwb.2 uc294iwb.1 uc294iwb.2 
ENSMUST00000238448.3 Gm9970 ENSMUST00000238448.3 Gm9970 (from geneSymbol) ENSMUST00000238448.1 ENSMUST00000238448.2 uc294iwe.1 uc294iwe.2 uc294iwe.3 uc294iwe.1 uc294iwe.2 uc294iwe.3 
ENSMUST00000238450.3 Pou2af2 ENSMUST00000238450.3 POU domain, class 2, associating factor 2, transcript variant 3 (from RefSeq NM_001372556.1) A0A5K1VW51 ENSMUST00000238450.1 ENSMUST00000238450.2 NM_001372556 OCAT1_MOUSE Pou2af2 Q9D8Q6 uc294iwg.1 uc294iwg.2 Transcriptional coactivator of POU2F3 (By similarity). This complex drives the development of tuft cells, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971). Interacts with POU2F3 (via the POU domain) in a DNA-dependent manner; this interaction recruits POU2AF2 to chromatin and increases POU2F3 transactivation activity. Cytoplasm, cytosol Nucleus Note=Recruited to chromatin by POU2F3. Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=Q9D8Q6-1; Sequence=Displayed; Name=2; IsoId=Q9D8Q6-2; Sequence=VSP_061593; Expressed in tuft cells of the small intestine, trachea, thymus, and colon. In the N-terminus possesses a conserved OCA domain for bivalent binding to class II POU domain-containing transcription factors and to an octamer DNA motif (5'-ATGAAAT-3'). Mutant mice generated by CRISPR-Cas9-mediated gene editing are born at normal Mendelian ratios, and have indistinguishable weight, morphology, fertility, and organ histology from normal mice. However, tuft cells in the trachea, small intestine, urethra, gall bladder, tongue, and nasal epithelium are indetectable in Pou2af2-/- mice, whereas a partial loss of tuft cells is observed in the colon. Belongs to the POU2AF family. molecular_function cellular_component biological_process uc294iwg.1 uc294iwg.2 
ENSMUST00000238455.2 Cldn34a ENSMUST00000238455.2 Cell junction, tight junction (from UniProt G3UW52) Cldn34a ENSMUST00000238455.1 G3UW52 G3UW52_MOUSE Gm7157 uc294iwl.1 uc294iwl.2 Cell junction, tight junction Belongs to the claudin family. molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc294iwl.1 uc294iwl.2 
ENSMUST00000238468.2 Rian ENSMUST00000238468.2 RNA imprinted and accumulated in nucleus (from RefSeq NR_028261.1) ENSMUST00000238468.1 NR_028261 uc294iwx.1 uc294iwx.2 uc294iwx.1 uc294iwx.2 
ENSMUST00000238474.2 Dthd1 ENSMUST00000238474.2 death domain containing 1 (from RefSeq NM_001170705.2) A0A571BG01 A0A571BG01_MOUSE Dthd1 ENSMUST00000238474.1 NM_001170705 uc294ixc.1 uc294ixc.2 uc294ixc.1 uc294ixc.2 
ENSMUST00000238478.3 Gm10382 ENSMUST00000238478.3 Gm10382 (from geneSymbol) ENSMUST00000238478.1 ENSMUST00000238478.2 LF195181 uc294ixe.1 uc294ixe.2 uc294ixe.3 uc294ixe.1 uc294ixe.2 uc294ixe.3 
ENSMUST00000238484.3 Gm9958 ENSMUST00000238484.3 Gm9958 (from geneSymbol) ENSMUST00000238484.1 ENSMUST00000238484.2 uc294ixj.1 uc294ixj.2 uc294ixj.3 uc294ixj.1 uc294ixj.2 uc294ixj.3 
ENSMUST00000238487.2 Ttc24 ENSMUST00000238487.2 Ttc24 (from geneSymbol) AK039884 ENSMUST00000238487.1 uc294ixm.1 uc294ixm.2 uc294ixm.1 uc294ixm.2 
ENSMUST00000238488.2 Ccm2l ENSMUST00000238488.2 cerebral cavernous malformation 2-like, transcript variant 1 (from RefSeq NM_001372363.1) A0A571BDK9 A0A571BDK9_MOUSE Ccm2l ENSMUST00000238488.1 NM_001372363 uc294ixn.1 uc294ixn.2 Belongs to the CCM2 family. uc294ixn.1 uc294ixn.2 
ENSMUST00000238499.3 Cldn34c2 ENSMUST00000238499.3 claudin 34C2 (from RefSeq NM_001378274.1) A0A571BG29 A0A571BG29_MOUSE Cldn34c2 ENSMUST00000238499.1 ENSMUST00000238499.2 NM_001378274 uc294ixv.1 uc294ixv.2 uc294ixv.3 Cell junction, tight junction Belongs to the claudin family. uc294ixv.1 uc294ixv.2 uc294ixv.3 
ENSMUST00000238500.2 Vwa3b ENSMUST00000238500.2 von Willebrand factor A domain containing 3B, transcript variant 1 (from RefSeq NM_001370828.1) A0A571BEM6 A0A571BEM6_MOUSE ENSMUST00000238500.1 NM_001370828 Vwa3b uc294ixw.1 uc294ixw.2 uc294ixw.1 uc294ixw.2 
ENSMUST00000238501.2 Gm5447 ENSMUST00000238501.2 Gm5447 (from geneSymbol) AK077314 ENSMUST00000238501.1 uc294ixx.1 uc294ixx.2 uc294ixx.1 uc294ixx.2 
ENSMUST00000238503.1 Cldn34c5 ENSMUST00000238503.1 Cell junction, tight junction (from UniProt A0A571BDD5) A0A571BDD5 A0A571BDD5_MOUSE Cldn34c5 Gm5945 uc294ixy.1 uc294ixy.2 uc294ixy.3 Cell junction, tight junction Belongs to the claudin family. uc294ixy.1 uc294ixy.2 uc294ixy.3 
ENSMUST00000238506.2 Catspere2 ENSMUST00000238506.2 cation channel sperm associated auxiliary subunit epsilon 2, transcript variant 3 (from RefSeq NM_001368822.1) A0A571BGH9 A0A571BGH9_MOUSE Catspere2 ENSMUST00000238506.1 NM_001368822 uc294iyb.1 uc294iyb.2 Belongs to the CATSPERD family. uc294iyb.1 uc294iyb.2 
ENSMUST00000238514.2 Gm2310 ENSMUST00000238514.2 Gm2310 (from geneSymbol) ENSMUST00000238514.1 uc294iyj.1 uc294iyj.2 uc294iyj.1 uc294iyj.2 
ENSMUST00000238517.2 Pramel45 ENSMUST00000238517.2 Belongs to the PRAME family. (from UniProt A0A571BEB1) A0A571BEB1 A0A571BEB1_MOUSE ENSMUST00000238517.1 Pramel45 uc294iym.1 uc294iym.2 Belongs to the PRAME family. uc294iym.1 uc294iym.2 
ENSMUST00000238519.2 Lsmem2 ENSMUST00000238519.2 leucine-rich single-pass membrane protein 2 (from RefSeq NM_001370877.1) A0A571BE98 A0A571BE98_MOUSE ENSMUST00000238519.1 Lsmem2 NM_001370877 uc294iyo.1 uc294iyo.2 uc294iyo.1 uc294iyo.2 
ENSMUST00000238521.2 Cfap92 ENSMUST00000238521.2 cilia and flagella associated protein 92, transcript variant 2 (from RefSeq NR_045482.2) 1810020O05Rik A0A571BDQ7 A0A571BDQ7_MOUSE Cfap92 ENSMUST00000238521.1 NR_045482 uc294iyq.1 uc294iyq.2 uc294iyq.1 uc294iyq.2 
ENSMUST00000238522.2 Lcorl ENSMUST00000238522.2 Lcorl (from geneSymbol) A0A571BEC4 A0A571BEC4_MOUSE BC066151 ENSMUST00000238522.1 Lcorl uc294iyr.1 uc294iyr.2 uc294iyr.1 uc294iyr.2 
ENSMUST00000238528.2 Btbd35f22 ENSMUST00000238528.2 Btbd35f22 (from geneSymbol) Btbd35f22 ENSMUST00000238528.1 J3QN64 J3QN64_MOUSE uc294iyw.1 uc294iyw.2 uc294iyw.1 uc294iyw.2 
ENSMUST00000238529.2 Gm50485 ENSMUST00000238529.2 Gm50485 (from geneSymbol) ENSMUST00000238529.1 uc294iyx.1 uc294iyx.2 uc294iyx.1 uc294iyx.2 
ENSMUST00000238536.2 Obscn ENSMUST00000238536.2 Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (By similarity). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (PubMed:23392350). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5- phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (By similarity). (from UniProt A2AAJ9) A2AAJ9 A2AB85 AY603754 B2FDE7 ENSMUST00000238536.1 Gm878 OBSCN_MOUSE Obscn Q695L2 Q811H7 uc294ize.1 uc294ize.2 Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (By similarity). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (PubMed:23392350). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5- phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (By similarity). Isoform 2 and isoform 3: bind phosphatidylinositol bisphosphates (PIP2s) via their PH domains and negatively regulate the PI3K/AKT/mTOR signaling pathway, thus contributing to the regulation of cardiomyocyte size and adhesion. Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Interacts (via protein kinase domain 1) with CDH2 and (via protein kinase domain 1) with ATP1B1 (PubMed:23392350). Isoform 2 is found in a complex with DSG2, DESM, GJA1, CDH2 and VCL (PubMed:28826662). Isoform 3 is found in a complex with DSG2, DESM, GJA1, CDH2, ANK3 and VCL (PubMed:28826662). Cytoplasm, myofibril, sarcomere, M line Cytoplasm, myofibril, sarcomere, Z line Cell membrane, sarcolemma Nucleus Secreted Note=Colocalizes with CDH2 and ATP1B1 to the sarcolemma and to intercalating disks in cardiac muscles. Colocalizes with ATP1B1 to M line and Z line in cardiac muscles. One or both small isoforms, one probably containing protein kinase domain 2 and partial protein kinase domain 1 and one containing only protein kinase domain 2, localize to the extracellular side of the sarcolemma. [Isoform 2]: Cell membrane [Isoform 3]: Cell membrane Event=Alternative splicing; Named isoforms=3; Comment=Two additional small isoforms seem to exist. ; Name=1; IsoId=A2AAJ9-1; Sequence=Displayed; Name=2 ; Synonyms=obsc-40 ; IsoId=A2AAJ9-2; Sequence=VSP_060093, VSP_060095, VSP_060096; Name=3 ; Synonyms=obsc-80 ; IsoId=A2AAJ9-3; Sequence=VSP_060093, VSP_060094, VSP_060097; Expressed in skeletal muscles including flexor digitorum brevis (FDB), soleus and tibialis anterior muscles, and to a lesser extent in heart muscles (at protein level) (PubMed:23392350). Isoform 2 and isoform 3 are expressed in the myocardium (at protein level) (PubMed:28826662). Isoform 2 and isoform 3 are expressed during late embryogenesis and throughout postnatal development in the myocardium (at protein level) (PubMed:28826662). Isoform 3 is the predominant form in mid-embryogenesis (11 dpc), and moderately decreases postnatally and in adulthood (at protein level) (PubMed:28826662). Isoform 2 increases significantly as development progresses (at protein evel) (PubMed:28826662). Autophosphorylated by protein kinase domain 1 and 2. Two small isoforms, one probably containing protein kinase domain 2 and a partial protein kinase domain 1 and one containing only protein kinase domain 2, are glycosylated. [Isoform 2]: Lacks the kinase domain. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Sequence=AAH44882.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleotide binding protein kinase activity protein serine/threonine kinase activity Rho guanyl-nucleotide exchange factor activity protein binding calmodulin binding ATP binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding extracellular region extracellular space nucleus cytoplasm cytosol striated muscle myosin thick filament plasma membrane protein phosphorylation multicellular organism development lipid binding phosphatidylinositol-5-phosphate binding negative regulation of phosphatidylinositol 3-kinase signaling intercalated disc membrane kinase activity phosphorylation nuclear body transferase activity sarcomere Z disc cell differentiation ankyrin binding M band titin binding phosphatidylinositol-3-phosphate binding regulation of Rho protein signal transduction sarcolemma phosphatidylinositol-3,4-bisphosphate binding cadherin binding protein autophosphorylation metal ion binding phosphatidylinositol-4-phosphate binding phosphatidylinositol bisphosphate binding uc294ize.1 uc294ize.2 
ENSMUST00000238539.2 Gm10134 ENSMUST00000238539.2 Gm10134 (from geneSymbol) ENSMUST00000238539.1 uc294izh.1 uc294izh.2 uc294izh.1 uc294izh.2 
ENSMUST00000238548.2 Gm32880 ENSMUST00000238548.2 Gm32880 (from geneSymbol) AK146386 ENSMUST00000238548.1 uc294izp.1 uc294izp.2 uc294izp.1 uc294izp.2 
ENSMUST00000238549.2 Gm17267 ENSMUST00000238549.2 Gm17267 (from geneSymbol) ENSMUST00000238549.1 FJ386433 uc294izq.1 uc294izq.2 uc294izq.1 uc294izq.2 
ENSMUST00000238551.2 Gm17361 ENSMUST00000238551.2 Gm17361 (from geneSymbol) ENSMUST00000238551.1 FJ386434 uc294izs.1 uc294izs.2 uc294izs.1 uc294izs.2 
ENSMUST00000238564.3 Gm5129 ENSMUST00000238564.3 Gm5129 (from geneSymbol) AK076721 ENSMUST00000238564.1 ENSMUST00000238564.2 uc294jaf.1 uc294jaf.2 uc294jaf.3 uc294jaf.1 uc294jaf.2 uc294jaf.3 
ENSMUST00000238565.2 D130052B06Rik ENSMUST00000238565.2 D130052B06Rik (from geneSymbol) AK051482 ENSMUST00000238565.1 uc294jag.1 uc294jag.2 uc294jag.1 uc294jag.2 
ENSMUST00000238569.2 Lrp8 ENSMUST00000238569.2 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, transcript variant 1 (from RefSeq NM_053073.3) Apoer2 ENSMUST00000238569.1 LRP8_MOUSE NM_053073 Q8CAK9 Q8CDF5 Q921B6 Q924X6 uc294jak.1 uc294jak.2 Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor- associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation (PubMed:12695510). May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (PubMed:18174160). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (PubMed:29336888). Homooligomer (By similarity). Interacts with VLDLR (By similarity). Reelin associates with two or more receptor molecules. Interacts with DAB1 and JNK-interacting proteins. Interacts with SNX17. Interacts with PCSK9 (By similarity). Interacts with MDK; this interaction is calcium dependent (PubMed:12573468). Interacts with CLU (By similarity). Q924X6; Q62108: Dlg4; NbExp=3; IntAct=EBI-432319, EBI-300895; Q924X6; P35438: Grin1; NbExp=4; IntAct=EBI-432319, EBI-400084; Q924X6; Q60841: Reln; NbExp=4; IntAct=EBI-432319, EBI-9248666; Q924X6; P02749: APOH; Xeno; NbExp=2; IntAct=EBI-432319, EBI-2114682; Q924X6; Q99068: Lrpap1; Xeno; NbExp=2; IntAct=EBI-432319, EBI-919734; Cell membrane ; Single-pass type I membrane protein Secreted. Note=Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q924X6-1; Sequence=Displayed; Name=2; IsoId=Q924X6-2; Sequence=VSP_010309; Name=3; Synonyms=ApoER2delta4-6,8-F; IsoId=Q924X6-5; Sequence=Not described; Expressed in neurons throughout the brain, with strong expression in pyramidal neurons of the hippocampus, granule cells of the dentate gyrus, cortical neurons and Purkinje cells of the cerebellum. Also expressed in the epithelium of the choroid plexus and of the blood vessels (apical expression), as well as in the epididymis. Expressed from 12 dpc to 16 dpc. Mice which are deficient in LRP8 have neuronal migration defect. The cytoplasmic domain is involved in the binding of DAB1 and in the recruitment of JNK-interacting proteins. Isoforms, which lack part of the cytoplasmic domain, are unable to recruit members of the family of JNK interacting proteins (JIP) to the cytoplasmic tail. O-glycosylated. Some alternatively spliced isoforms lack the O- linked sugar domain. Undergoes sequential, furin and gamma-secretase dependent, proteolytic processing, resulting in the extracellular release of the entire ligand-binding domain as a soluble polypeptide and in the intracellular domain (ICD) release into the cytoplasm. The gamma- secretase-dependent proteolytical processing occurs after the bulk of the extracellular domain has been shed, in a furin-dependent manner, in alternatively spliced isoforms carrying the furin cleavage site. Hypoglycosylation (mainly hypo-O-glycosylation) leads to increased extracellular cleavage, which in turn results in accelerating release of the intracellular domain (ICD) by the gamma-secretase. The resulting receptor fragment is able to inhibit Reelin signaling and in particular the Reelin-induced DAB1 phosphorylation. Tyrosine phosphorylated upon apoE binding. Ubiquitinated by MYLIP leading to degradation. Does not affect endocytosis of SEPP1 in the kidney proximal tubule (PubMed:18174160). Targeted disruption of LRP8 and VLVLR together results in a phenotype virtually indistinguishable from that seen in 'reeler' and 'scrambler' mice. Subtle effects of VLDLR deletion are found mainly in the cerebellum, whereas lack of LRP8 predominantly affects the positioning of the neurons in the neocortex. Besides brain formation defects, LRP8-deficient mice also exhibit male infertility. [Isoform 3]: Contains a 18 aa insert in the extracellular part which carries a furin cleavage site. Belongs to the LDLR family. beta-amyloid binding low-density lipoprotein receptor activity calcium ion binding protein binding extracellular region extracellular space microtubule associated complex plasma membrane caveola endocytosis chemical synaptic transmission high-density lipoprotein particle binding cell surface postsynaptic density membrane integral component of membrane kinesin binding ventral spinal cord development ammon gyrus development hippocampus development layer formation in cerebral cortex very-low-density lipoprotein particle receptor activity axon dendrite positive regulation of CREB transcription factor activity apolipoprotein binding reelin receptor activity reelin-mediated signaling pathway regulation of apoptotic process neuronal cell body receptor complex regulation of innate immune response positive regulation of protein kinase activity protein N-terminus binding calcium-dependent protein binding dendrite morphogenesis positive regulation of peptidyl-tyrosine phosphorylation modulation of synaptic transmission positive regulation of dendritic spine morphogenesis positive regulation of protein tyrosine kinase activity positive regulation of dendrite development uc294jak.1 uc294jak.2 
ENSMUST00000238574.2 Gm50484 ENSMUST00000238574.2 Gm50484 (from geneSymbol) ENSMUST00000238574.1 uc294jao.1 uc294jao.2 uc294jao.1 uc294jao.2 
ENSMUST00000238582.2 Gm6899 ENSMUST00000238582.2 Gm6899 (from geneSymbol) BC147450 ENSMUST00000238582.1 uc294jau.1 uc294jau.2 uc294jau.1 uc294jau.2 
ENSMUST00000238583.2 Gm21411 ENSMUST00000238583.2 Gm21411 (from geneSymbol) A0A571BDT7 A0A571BDT7_MOUSE AK049536 ENSMUST00000238583.1 Gm21411 uc294jav.1 uc294jav.2 uc294jav.1 uc294jav.2 
ENSMUST00000238598.2 4930507D05Rik ENSMUST00000238598.2 RIKEN cDNA 4930507D05 gene (from RefSeq NR_027926.1) ENSMUST00000238598.1 NR_027926 uc294jbh.1 uc294jbh.2 uc294jbh.1 uc294jbh.2 
ENSMUST00000238599.2 Mgam ENSMUST00000238599.2 maltase-glucoamylase, transcript variant 1 (from RefSeq NM_001368875.1) A0A571BF69 A0A571BF69_MOUSE ENSMUST00000238599.1 Mgam NM_001368875 uc294jbi.1 uc294jbi.2 Belongs to the glycosyl hydrolase 31 family. Lacks conserved residue(s) required for the propagation of feature annotation. uc294jbi.1 uc294jbi.2 
ENSMUST00000238604.2 Gm17522 ENSMUST00000238604.2 Gm17522 (from geneSymbol) ENSMUST00000238604.1 FJ386433 uc294jbn.1 uc294jbn.2 uc294jbn.1 uc294jbn.2 
ENSMUST00000238612.2 ENSMUSG00000121827 ENSMUST00000238612.2 ENSMUSG00000121827 (from geneSymbol) ENSMUST00000238612.1 uc294jbu.1 uc294jbu.2 uc294jbu.1 uc294jbu.2 
ENSMUST00000238621.2 Gm17584 ENSMUST00000238621.2 Gm17584 (from geneSymbol) ENSMUST00000238621.1 FJ386434 uc294jcd.1 uc294jcd.2 uc294jcd.1 uc294jcd.2 
ENSMUST00000238623.3 Zfp997 ENSMUST00000238623.3 zinc finger protein 997 (from RefSeq NM_001177832.1) A0A571BGF1 A0A571BGF1_MOUSE ENSMUST00000238623.1 ENSMUST00000238623.2 Gm10324 NM_001177832 Zfp997 uc294jcf.1 uc294jcf.2 uc294jcf.3 uc294jcf.1 uc294jcf.2 uc294jcf.3 
ENSMUST00000238626.2 Gm17416 ENSMUST00000238626.2 predicted gene, 17416 (from RefSeq NM_001416772.1) A0A571BDR6 A0A571BDR6_MOUSE ENSMUST00000238626.1 Gm17416 NM_001416772 uc294jci.1 uc294jci.2 Has antibacterial activity. Secreted Belongs to the beta-defensin family. uc294jci.1 uc294jci.2 
ENSMUST00000238631.3 Cldn34c3 ENSMUST00000238631.3 Cell junction, tight junction (from UniProt A0A991ENX4) A0A991ENX4 A0A991ENX4_MOUSE Cldn34c3 ENSMUST00000238631.1 ENSMUST00000238631.2 uc294jcl.1 uc294jcl.2 uc294jcl.3 Cell junction, tight junction Belongs to the claudin family. uc294jcl.1 uc294jcl.2 uc294jcl.3 
ENSMUST00000238632.2 Btbd35f9 ENSMUST00000238632.2 Btbd35f9 (from geneSymbol) A2BFZ7 A2BFZ7_MOUSE AK006065 Btbd35f11 Btbd35f9 ENSMUST00000238632.1 uc294jcm.1 uc294jcm.2 molecular_function cellular_component biological_process uc294jcm.1 uc294jcm.2 
ENSMUST00000238633.2 Erich6b ENSMUST00000238633.2 glutamate rich 6B, transcript variant 1 (from RefSeq NM_001369022.1) A0A571BEV3 A0A571BEV3_MOUSE ENSMUST00000238633.1 Erich6b NM_001369022 uc294jcn.1 uc294jcn.2 uc294jcn.1 uc294jcn.2 
ENSMUST00000238635.2 Gm26661 ENSMUST00000238635.2 Gm26661 (from geneSymbol) ENSMUST00000238635.1 uc294jcp.1 uc294jcp.2 uc294jcp.1 uc294jcp.2 
ENSMUST00000238638.2 Lhb ENSMUST00000238638.2 stabilizer of axonemal microtubules 3 (from RefSeq NM_001402948.1) A0A571BEL8 A0A571BEL8_MOUSE ENSMUST00000238638.1 Lhb NM_001402948 uc294jcr.1 uc294jcr.2 uc294jcr.1 uc294jcr.2 
ENSMUST00000238639.2 Gm10840 ENSMUST00000238639.2 Gm10840 (from geneSymbol) ENSMUST00000238639.1 uc294jcs.1 uc294jcs.2 uc294jcs.1 uc294jcs.2 
ENSMUST00000238653.2 4933427D14Rik ENSMUST00000238653.2 RIKEN cDNA 4933427D14 gene, transcript variant 4 (from RefSeq NR_155066.1) 4933427D14Rik A0A0R4J1C3 A0A0R4J1C3_MOUSE ENSMUST00000238653.1 NR_155066 uc294jde.1 uc294jde.2 centriole replication uc294jde.1 uc294jde.2 
ENSMUST00000238655.2 Gm50465 ENSMUST00000238655.2 Gm50465 (from geneSymbol) ENSMUST00000238655.1 FJ386434 uc294jdg.1 uc294jdg.2 uc294jdg.1 uc294jdg.2 
ENSMUST00000238662.2 Ccdc168 ENSMUST00000238662.2 coiled-coil domain containing 168 (from RefSeq NM_001376984.1) A0A571BEV2 A0A571BEV2_MOUSE Ccdc168 ENSMUST00000238662.1 Gm8251 NM_001376984 uc294jdm.1 uc294jdm.2 uc294jdm.1 uc294jdm.2 
ENSMUST00000238664.2 Gm50475 ENSMUST00000238664.2 Gm50475 (from geneSymbol) ENSMUST00000238664.1 uc294jdo.1 uc294jdo.2 uc294jdo.1 uc294jdo.2 
ENSMUST00000238668.2 Wdr27 ENSMUST00000238668.2 Wdr27 (from geneSymbol) A0A338P6H6 A0A338P6H6_MOUSE AK077050 ENSMUST00000238668.1 Wdr27 uc294jdq.1 uc294jdq.2 uc294jdq.1 uc294jdq.2 
ENSMUST00000238669.2 Zfp827 ENSMUST00000238669.2 Cytoplasm Nucleus (from UniProt A0A571BE87) A0A571BE87 A0A571BE87_MOUSE AK154905 ENSMUST00000238669.1 Zfp827 uc294jdr.1 uc294jdr.2 Cytoplasm Nucleus uc294jdr.1 uc294jdr.2 
ENSMUST00000238670.2 Kcnc4 ENSMUST00000238670.2 Membrane ; Multi- pass membrane protein (from UniProt A0A571BG98) A0A571BG98 A0A571BG98_MOUSE BC024837 ENSMUST00000238670.1 Kcnc4 uc294jds.1 uc294jds.2 Membrane ; Multi- pass membrane protein uc294jds.1 uc294jds.2 
ENSMUST00000238671.2 Gm10642 ENSMUST00000238671.2 predicted gene 10642 (from RefSeq NR_188869.1) ENSMUST00000238671.1 NR_188869 uc294jdt.1 uc294jdt.2 uc294jdt.1 uc294jdt.2 
ENSMUST00000238678.2 4930518I15Rik ENSMUST00000238678.2 4930518I15Rik (from geneSymbol) AK015827 ENSMUST00000238678.1 uc294jea.1 uc294jea.2 uc294jea.1 uc294jea.2 
ENSMUST00000238680.2 Adgrg6 ENSMUST00000238680.2 Membrane ; Multi- pass membrane protein (from UniProt A0A571BEJ4) A0A571BEJ4 A0A571BEJ4_MOUSE AB183545 Adgrg6 ENSMUST00000238680.1 uc294jec.1 uc294jec.2 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Lacks conserved residue(s) required for the propagation of feature annotation. uc294jec.1 uc294jec.2 
ENSMUST00000238684.2 Abr ENSMUST00000238684.2 Cell projection, axon Cell projection, dendritic spine Synapse (from UniProt A0A571BG95) A0A571BG95 A0A571BG95_MOUSE Abr BC058708 ENSMUST00000238684.1 uc294jeg.1 uc294jeg.2 Cell projection, axon Cell projection, dendritic spine Synapse uc294jeg.1 uc294jeg.2 
ENSMUST00000238686.2 Gm50489 ENSMUST00000238686.2 Gm50489 (from geneSymbol) ENSMUST00000238686.1 uc294jei.1 uc294jei.2 uc294jei.1 uc294jei.2 
ENSMUST00000238695.2 6330403K07Rik ENSMUST00000238695.2 RIKEN cDNA 6330403K07 gene (from RefSeq NM_134022.2) 6330403K07Rik ENSMUST00000238695.1 NM_134022 Q8VBZ2 Q8VBZ2_MOUSE UGS148 uc294jer.1 uc294jer.2 membrane integral component of membrane uc294jer.1 uc294jer.2 
ENSMUST00000238707.2 Gm50457 ENSMUST00000238707.2 predicted gene, 50457 (from RefSeq NM_001367923.2) A0A571BEW1 A0A571BEW1_MOUSE ENSMUST00000238707.1 Gm50457 NM_001367923 uc294jfd.1 uc294jfd.2 Membrane ; Multi- pass membrane protein uc294jfd.1 uc294jfd.2 
ENSMUST00000238708.2 Gm21679 ENSMUST00000238708.2 Gm21679 (from geneSymbol) ENSMUST00000238708.1 FJ541101 uc294jfe.1 uc294jfe.2 uc294jfe.1 uc294jfe.2 
ENSMUST00000238712.2 Ikzf4 ENSMUST00000238712.2 Ikzf4 (from geneSymbol) A0A571BEH5 A0A571BEH5_MOUSE ENSMUST00000238712.1 Ikzf4 NM_001428882 uc294jfi.1 uc294jfi.2 uc294jfi.1 uc294jfi.2 
ENSMUST00000238714.2 Terc ENSMUST00000238714.2 telomerase RNA component (from RefSeq NR_001579.1) ENSMUST00000238714.1 NR_001579 uc294jfj.1 uc294jfj.2 Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Telomerase may also participate in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. In contrast with human telomerase, murine telomerase is expressed in many normal postnatal somatic tissues. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC115543.1 [ECO:0000345] ##Evidence-Data-END## uc294jfj.1 uc294jfj.2 
ENSMUST00000238724.2 D930007J09Rik ENSMUST00000238724.2 D930007J09Rik (from geneSymbol) ENSMUST00000238724.1 LF199476 uc294jft.1 uc294jft.2 uc294jft.1 uc294jft.2 
ENSMUST00000238728.2 Spin2e ENSMUST00000238728.2 Belongs to the SPIN/STSY family. (from UniProt A0A571BDE3) A0A571BDE3 A0A571BDE3_MOUSE ENSMUST00000238728.1 Spin2e uc294jfx.1 uc294jfx.2 Belongs to the SPIN/STSY family. uc294jfx.1 uc294jfx.2 
ENSMUST00000238733.2 Tmem200b ENSMUST00000238733.2 transmembrane protein 200B (from RefSeq NM_001201367.2) D3Z0P8 D3Z0P8_MOUSE ENSMUST00000238733.1 NM_001201367 Tmem200b uc294jgc.1 uc294jgc.2 Membrane ; Multi- pass membrane protein Belongs to the TMEM200 family. molecular_function cellular_component biological_process membrane integral component of membrane uc294jgc.1 uc294jgc.2 
ENSMUST00000238746.2 Arhgef28 ENSMUST00000238746.2 Rho guanine nucleotide exchange factor 28, transcript variant 5 (from RefSeq NM_001408687.1) A0A571BEH9 A0A571BEH9_MOUSE Arhgef28 ENSMUST00000238746.1 NM_001408687 uc294jgo.1 uc294jgo.2 uc294jgo.1 uc294jgo.2 
ENSMUST00000238749.2 Neb ENSMUST00000238749.2 Neb (from geneSymbol) A0A571BF58 A0A571BF58_MOUSE ENSMUST00000238749.1 Neb U58108 uc294jgr.1 uc294jgr.2 uc294jgr.1 uc294jgr.2 
ENSMUST00000238755.2 Ssu2 ENSMUST00000238755.2 Ssu2 (from geneSymbol) A0A571BFB5 A0A571BFB5_MOUSE BC116438 ENSMUST00000238755.1 Ssu2 uc294jgw.1 uc294jgw.2 uc294jgw.1 uc294jgw.2 
ENSMUST00000238757.2 Gm10553 ENSMUST00000238757.2 Gm10553 (from geneSymbol) ENSMUST00000238757.1 uc294jgy.1 uc294jgy.2 uc294jgy.1 uc294jgy.2 
ENSMUST00000238764.2 Gm50461 ENSMUST00000238764.2 Gm50461 (from geneSymbol) A0A571BF43 A0A571BF43_MOUSE BC031810 ENSMUST00000238764.1 Gm50461 uc294jhf.1 uc294jhf.2 uc294jhf.1 uc294jhf.2 
ENSMUST00000238765.2 Btbd35f26 ENSMUST00000238765.2 BTB domain containing 35, family member 26 (from RefSeq NM_001374723.1) A0A571BD55 A0A571BD55_MOUSE Btbd35f26 ENSMUST00000238765.1 NM_001374723 uc294jhg.1 uc294jhg.2 uc294jhg.1 uc294jhg.2 
ENSMUST00000238768.2 Arhgap33os ENSMUST00000238768.2 Arhgap33os (from geneSymbol) A0A571BD42 A0A571BD42_MOUSE Arhgap33os BC065044 ENSMUST00000238768.1 uc294jhj.1 uc294jhj.2 uc294jhj.1 uc294jhj.2 
ENSMUST00000238770.2 Il11ra2 ENSMUST00000238770.2 interleukin 11 receptor subunit alpha 2, transcript variant 1 (from RefSeq NM_010550.4) A2RTL4 B1AXR8 ENSMUST00000238770.1 I11RB_MOUSE NM_010550 O09074 P70225 Q78DW8 uc294jhl.1 uc294jhl.2 Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. On ligand binding, forms a multimer complex with IL6ST/gp130. Membrane; Single-pass type I membrane protein. Expression restricted to testis, lymph node and thymus. Highest level in testis. Il11ra2 appears to arise through gene duplication of ancestral origin and has been lost in some inbred mouse strains. Belongs to the type I cytokine receptor family. Type 3 subfamily. cytokine receptor activity interleukin-11 receptor activity positive regulation of cell proliferation external side of plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway cytokine binding interleukin-11 binding interleukin-11-mediated signaling pathway receptor complex uc294jhl.1 uc294jhl.2 
ENSMUST00000238772.2 Btbd35f25 ENSMUST00000238772.2 Btbd35f25 (from geneSymbol) A0A571BG45 A0A571BG45_MOUSE Btbd35f25 ENSMUST00000238772.1 uc294jhm.1 uc294jhm.2 uc294jhm.1 uc294jhm.2 
ENSMUST00000238778.3 4930426L09Rik ENSMUST00000238778.3 4930426L09Rik (from geneSymbol) AK015207 ENSMUST00000238778.1 ENSMUST00000238778.2 uc294jhs.1 uc294jhs.2 uc294jhs.3 uc294jhs.1 uc294jhs.2 uc294jhs.3 
ENSMUST00000238789.2 Ankub1 ENSMUST00000238789.2 Ankub1 (from geneSymbol) A0A5F8MPK3 A0A5F8MPK3_MOUSE AK138483 Ankub1 ENSMUST00000238789.1 uc294jid.1 uc294jid.2 uc294jid.1 uc294jid.2 
ENSMUST00000238790.2 Syt16 ENSMUST00000238790.2 synaptotagmin XVI, transcript variant 10 (from RefSeq NM_001422973.1) ENSMUST00000238790.1 NM_001422973 Q3UVM4 Q6PGM6 Q7TN83 Q8BJ41 SYT16_MOUSE Strep14 Syt14l Syt14r uc294jie.1 uc294jie.2 May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent. Homodimer. Can also form heterodimers. Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7TN83-1; Sequence=Displayed; Name=2; IsoId=Q7TN83-2; Sequence=VSP_021382, VSP_021384, VSP_021385; Name=3; IsoId=Q7TN83-3; Sequence=VSP_021381, VSP_021383; Highly expressed in heart and testis. Moderately expressed in kidney. Weakly expressed at 7 dpc and remains constant from 11 dpc to 17 dpc. Belongs to the synaptotagmin family. Sequence=BAC27947.1; Type=Frameshift; Evidence=; phospholipid binding exocytosis integral component of membrane protein homodimerization activity protein heterodimerization activity calcium-dependent phospholipid binding uc294jie.1 uc294jie.2 
ENSMUST00000238795.2 Slc1a7 ENSMUST00000238795.2 Membrane ulti-pass membrane protein (from UniProt Z4YKJ7) BC030400 ENSMUST00000238795.1 Slc1a7 Z4YKJ7 Z4YKJ7_MOUSE uc294jij.1 uc294jij.2 Membrane ulti-pass membrane protein Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. symporter activity membrane integral component of membrane transmembrane transport uc294jij.1 uc294jij.2 
ENSMUST00000238801.2 B830012L14Rik ENSMUST00000238801.2 B830012L14Rik (from geneSymbol) ENSMUST00000238801.1 KY467655 uc294jip.1 uc294jip.2 uc294jip.1 uc294jip.2 
ENSMUST00000238808.2 Sall3 ENSMUST00000238808.2 spalt like transcription factor 3, transcript variant 1 (from RefSeq NM_001369133.1) A0A5F8MPC9 A0A5F8MPC9_MOUSE ENSMUST00000238808.1 NM_001369133 Sall3 uc294jiw.1 uc294jiw.2 Nucleus Belongs to the sal C2H2-type zinc-finger protein family. uc294jiw.1 uc294jiw.2 
ENSMUST00000238818.2 Ppp6r2 ENSMUST00000238818.2 Belongs to the SAPS family. (from UniProt A0A5F8MQ25) A0A5F8MQ25 A0A5F8MQ25_MOUSE BC024879 ENSMUST00000238818.1 Ppp6r2 uc294jjg.1 uc294jjg.2 Belongs to the SAPS family. uc294jjg.1 uc294jjg.2 
ENSMUST00000238822.2 Gm53010 ENSMUST00000238822.2 Gm53010 (from geneSymbol) AK028711 ENSMUST00000238822.1 uc294jjk.1 uc294jjk.2 uc294jjk.1 uc294jjk.2 
ENSMUST00000238823.2 Celf5 ENSMUST00000238823.2 CUGBP, Elav-like family member 5, transcript variant 6 (from RefSeq NM_001379187.1) A0A5F8MPH2 A0A5F8MPH2_MOUSE Celf5 ENSMUST00000238823.1 NM_001379187 uc294jjl.1 uc294jjl.2 Nucleus Belongs to the CELF/BRUNOL family. uc294jjl.1 uc294jjl.2 
ENSMUST00000238833.2 Tmem61 ENSMUST00000238833.2 transmembrane protein 61 (from RefSeq NM_001370848.1) A0A5F8MPC2 A0A5F8MPC2_MOUSE ENSMUST00000238833.1 NM_001370848 Tmem61 mCG_62296 uc294jjv.1 uc294jjv.2 uc294jjv.1 uc294jjv.2 
ENSMUST00000238847.2 Retnla ENSMUST00000238847.2 resistin like alpha (from RefSeq NM_020509.4) ENSMUST00000238847.1 Fizz1 Himf NM_020509 Pmng1 Q9D8Y4 Q9EP95 RETNA_MOUSE uc294jkj.1 uc294jkj.2 Probable hormone. Plays a role in pulmonary vascular remodeling. Monomer. Secreted. Highest levels in adipose tissue. Belongs to the resistin/FIZZ family. Sequence=BAB25104.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; hormone activity extracellular region extracellular space signal transduction uc294jkj.1 uc294jkj.2 
ENSMUST00000238849.2 Cgn ENSMUST00000238849.2 Cgn (from geneSymbol) A0A5F8MPT6 A0A5F8MPT6_MOUSE AK173148 Cgn ENSMUST00000238849.1 uc294jkl.1 uc294jkl.2 uc294jkl.1 uc294jkl.2 
ENSMUST00000238856.2 Tnk2 ENSMUST00000238856.2 Membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus (from UniProt A0A5F8MPC4) A0A5F8MPC4 A0A5F8MPC4_MOUSE DQ666696 ENSMUST00000238856.1 Tnk2 uc294jks.1 uc294jks.2 Membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus uc294jks.1 uc294jks.2 
ENSMUST00000238857.2 Gm52992 ENSMUST00000238857.2 Gm52992 (from geneSymbol) ENSMUST00000238857.1 uc294jkt.1 uc294jkt.2 uc294jkt.1 uc294jkt.2 
ENSMUST00000238863.2 Prdm11 ENSMUST00000238863.2 PR domain containing 11, transcript variant 2 (from RefSeq NM_001368849.1) A0A5F8MPE3 A0A5F8MPE3_MOUSE ENSMUST00000238863.1 NM_001368849 Prdm11 uc294jkz.1 uc294jkz.2 uc294jkz.1 uc294jkz.2 
ENSMUST00000238876.2 1700014B07Rik ENSMUST00000238876.2 1700014B07Rik (from geneSymbol) 1700014B07Rik A0A5F8MPC3 A0A5F8MPC3_MOUSE ENSMUST00000238876.1 uc294jll.1 uc294jll.2 uc294jll.1 uc294jll.2 
ENSMUST00000238882.2 Agt ENSMUST00000238882.2 angiotensinogen, transcript variant 2 (from RefSeq NM_007428.4) A0A5F8MPW1 A0A5F8MPW1_MOUSE Agt ENSMUST00000238882.1 NM_007428 uc294jlr.1 uc294jlr.2 Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Stimulates aldosterone release. Secreted Belongs to the serpin family. uc294jlr.1 uc294jlr.2 
ENSMUST00000238894.2 Etv3l ENSMUST00000238894.2 ets variant 3-like (from RefSeq NM_001370856.1) A0A5F8MPE2 A0A5F8MPE2_MOUSE ENSMUST00000238894.1 Etv3l NM_001370856 uc294jmd.1 uc294jmd.2 Nucleus Belongs to the ETS family. uc294jmd.1 uc294jmd.2 
ENSMUST00000238900.3 Cyp11b2 ENSMUST00000238900.3 cytochrome P450, family 11, subfamily b, polypeptide 2 (from RefSeq NM_009991.4) C11B2_MOUSE Cyp11b-2 ENSMUST00000238900.1 ENSMUST00000238900.2 NM_009991 P15539 Q14AB5 Q64661 uc294jmj.1 uc294jmj.2 uc294jmj.3 A cytochrome P450 monooxygenase that catalyzes the biosynthesis of aldosterone, the main mineralocorticoid in the human body responsible for salt and water homeostasis, thus involved in blood pressure regulation, arterial hypertension, and the development of heart failure. Catalyzes three sequential oxidative reactions of 11- deoxycorticosterone (21-hydroxyprogesterone), namely 11-beta hydroxylation, followed by two successive oxidations at C18 yielding 18-hydroxy and then 18-oxo intermediates (that would not leave the enzyme active site during the consecutive hydroxylation reactions), ending with the formation of aldosterone. Can also produce 18- hydroxycortisol and 18-oxocortisol, derived from successive oxidations of cortisol at C18, normally found at very low levels, but significantly increased in primary aldosteronism, the most common form of secondary hypertension. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Could also be involved in the androgen metabolic pathway. Reaction=a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] = an 11beta- hydroxysteroid + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:15629, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:35341, ChEBI:CHEBI:35346; EC=1.14.15.4; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15630; Evidence=; Reaction=21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = corticosterone + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:46104, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16827, ChEBI:CHEBI:16973, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46105; Evidence=; Reaction=corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18- hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:11872, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16485, ChEBI:CHEBI:16827, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; EC=1.14.15.5; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11873; Evidence=; Reaction=18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = aldosterone + 2 H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:50792, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16485, ChEBI:CHEBI:27584, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50793; Evidence=; Reaction=11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = cortisol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:46100, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17650, ChEBI:CHEBI:28324, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46101; Evidence=; Reaction=21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:76151, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16973, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:195166; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76152; Evidence=; Reaction=cortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18- hydroxycortisol + H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:76019, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17650, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:89455; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76020; Evidence=; Reaction=18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:76023, Rhea:RHEA-COMP:9998, Rhea:RHEA-COMP:9999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:89213, ChEBI:CHEBI:89455; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76024; Evidence=; Name=heme; Xref=ChEBI:CHEBI:30413; Evidence=; Steroid biosynthesis. Mitochondrion inner membrane ; Peripheral membrane protein Belongs to the cytochrome P450 family. regulation of systemic arterial blood pressure by circulatory renin-angiotensin regulation of blood volume by renal aldosterone monooxygenase activity steroid 11-beta-monooxygenase activity iron ion binding mitochondrion mitochondrial inner membrane steroid biosynthetic process C21-steroid hormone biosynthetic process glucocorticoid biosynthetic process cholesterol metabolic process regulation of blood pressure membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding dendrite mitochondrial membrane aldosterone biosynthetic process cortisol metabolic process cortisol biosynthetic process drinking behavior positive regulation of blood pressure metal ion binding corticosterone 18-monooxygenase activity ion homeostasis oxidation-reduction process cellular response to peptide hormone stimulus uc294jmj.1 uc294jmj.2 uc294jmj.3 
ENSMUST00000238906.2 Aff3 ENSMUST00000238906.2 Putative transcription activator that may function in lymphoid development and oncogenesis. (from UniProt P51827) AFF3_MOUSE BC052061 ENSMUST00000238906.1 Laf4 P51827 Q80WS6 uc294jmo.1 uc294jmo.2 Putative transcription activator that may function in lymphoid development and oncogenesis. Nucleus. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51827-1; Sequence=Displayed; Name=2; IsoId=P51827-2; Sequence=VSP_022225, VSP_022226; Highest levels found in lymphoid tissues, lower levels in brain and lung. [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the AF4 family. DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol transcription, DNA-templated regulation of transcription, DNA-templated transcription elongation factor complex nuclear body ELL-EAF complex response to tumor necrosis factor embryonic hindlimb morphogenesis uc294jmo.1 uc294jmo.2 
ENSMUST00000238910.2 Gm56675 ENSMUST00000238910.2 Gm56675 (from geneSymbol) A0A5F8MPN6 A0A5F8MPN6_MOUSE AB017697 ENSMUST00000238910.1 Gm56675 uc294jms.1 uc294jms.2 uc294jms.1 uc294jms.2 
ENSMUST00000238911.2 Cfap141 ENSMUST00000238911.2 cilia and flagella associated protein 141 (from RefSeq NM_028567.2) CP141_MOUSE Cfap141 ENSMUST00000238911.1 NM_028567 Q9D9D9 uc294jmt.1 uc294jmt.2 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Cytoplasm, cytoskeleton, cilium axoneme Sequence=AAH48560.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB24846.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; molecular_function cellular_component biological_process uc294jmt.1 uc294jmt.2 
ENSMUST00000238915.2 6330411D24Rik ENSMUST00000238915.2 6330411D24Rik (from geneSymbol) 6330411D24Rik A0A5F8MPF9 A0A5F8MPF9_MOUSE AK018156 ENSMUST00000238915.1 uc294jmx.1 uc294jmx.2 uc294jmx.1 uc294jmx.2 
ENSMUST00000238919.2 Zcwpw2 ENSMUST00000238919.2 zinc finger, CW type with PWWP domain 2 (from RefSeq NM_001378466.1) A0A5F8MP94 ENSMUST00000238919.1 NM_001378466 Q08EN7 ZCPW2_MOUSE uc294jnb.1 uc294jnb.2 Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (By similarity). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q08EN7-1; Sequence=Displayed; Name=2; IsoId=Q08EN7-2; Sequence=VSP_060790, VSP_060791; The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3. zinc ion binding metal ion binding uc294jnb.1 uc294jnb.2 
ENSMUST00000238926.2 Rgsl1 ENSMUST00000238926.2 regulator of G-protein signaling like 1, transcript variant 1 (from RefSeq NM_001368270.1) A0A5F8MPV0 A0A5F8MPV0_MOUSE ENSMUST00000238926.1 NM_001368270 Rgsl1 uc294jng.1 uc294jng.2 uc294jng.1 uc294jng.2 
ENSMUST00000238930.2 Tmem205 ENSMUST00000238930.2 transmembrane protein 205, transcript variant 6 (from RefSeq NR_045606.1) ENSMUST00000238930.1 NR_045606 Q91XE8 Q9JME6 TM205_MOUSE uc294jnk.1 uc294jnk.2 Membrane ; Multi-pass membrane protein Belongs to the TMEM205 family. molecular_function biological_process membrane integral component of membrane uc294jnk.1 uc294jnk.2 
ENSMUST00000238932.2 Ei24 ENSMUST00000238932.2 etoposide induced 2.4 mRNA, transcript variant 1 (from RefSeq NM_001199494.2) EI24_MOUSE ENSMUST00000238932.1 NM_001199494 Pig8 Q3T9X1 Q3TVX9 Q3UGS7 Q61070 uc294jnm.1 uc294jnm.2 Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). Interacts with BCL2. Nucleus membrane ; Multi-pass membrane protein Cytoplasm Endoplasmic reticulum membrane ; Multi-pass membrane protein Found in all the examined tissues. High expression was found in liver, skeletal muscle, pancreas, kidney heart and to a lesser extent in brain, placenta and lung. By etoposide treatment, induction requires p53. Etoposide induces DNA damage in cells by inhibiting DNA topoisomerase II, and ultimately causes apoptotic cell death. Belongs to the EI24 family. Sequence=AAC52483.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE28130.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE35489.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAE42899.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol autophagy apoptotic process intrinsic apoptotic signaling pathway in response to DNA damage membrane integral component of membrane macroautophagy negative regulation of cell growth nuclear membrane negative regulation of protein import into nucleus response to drug neuromuscular process controlling balance cellular response to UV-C positive regulation of intrinsic apoptotic signaling pathway uc294jnm.1 uc294jnm.2 
ENSMUST00000238934.2 Rskr ENSMUST00000238934.2 ribosomal protein S6 kinase related, transcript variant 13 (from RefSeq NR_175868.1) A0A5F8MPD4 A0A5F8MPD4_MOUSE ENSMUST00000238934.1 NR_175868 Rskr uc294jnn.1 uc294jnn.2 uc294jnn.1 uc294jnn.2 
ENSMUST00000238935.2 Bin2 ENSMUST00000238935.2 Bin2 (from geneSymbol) A0A5F8MQ05 A0A5F8MQ05_MOUSE BC114419 Bin2 ENSMUST00000238935.1 uc294jno.1 uc294jno.2 uc294jno.1 uc294jno.2 
ENSMUST00000238938.2 Rplp2-ps1 ENSMUST00000238938.2 Plays an important role in the elongation step of protein synthesis. (from UniProt A0A5F8MPY2) A0A5F8MPY2 A0A5F8MPY2_MOUSE BC055860 ENSMUST00000238938.1 Rplp2-ps1 uc294jnr.1 uc294jnr.2 Plays an important role in the elongation step of protein synthesis. Belongs to the eukaryotic ribosomal protein P1/P2 family. uc294jnr.1 uc294jnr.2 
ENSMUST00000238941.2 Ldlrad2 ENSMUST00000238941.2 low density lipoprotein receptor class A domain containing 2, transcript variant 2 (from RefSeq NM_001405419.1) A0A5F8MPH1 A0A5F8MPH1_MOUSE ENSMUST00000238941.1 Ldlrad2 NM_001405419 uc294jnu.1 uc294jnu.2 Lacks conserved residue(s) required for the propagation of feature annotation. uc294jnu.1 uc294jnu.2 
ENSMUST00000238951.2 Egfl7 ENSMUST00000238951.2 Lacks conserved residue(s) required for the propagation of feature annotation. (from UniProt Q3UTJ7) AK156158 ENSMUST00000238951.1 Egfl7 Q3UTJ7 Q3UTJ7_MOUSE uc294joe.1 uc294joe.2 Lacks conserved residue(s) required for the propagation of feature annotation. positive regulation of endothelial cell proliferation calcium ion binding negative regulation of Notch signaling pathway uc294joe.1 uc294joe.2 
ENSMUST00000238960.2 Clca4a ENSMUST00000238960.2 chloride channel accessory 4A (from RefSeq NM_207208.3) A0A5F8MQB6 A0A5F8MQB6_MOUSE Clca4a ENSMUST00000238960.1 NM_207208 uc294jon.1 uc294jon.2 Belongs to the CLCR family. uc294jon.1 uc294jon.2 
ENSMUST00000238967.2 Tnxb ENSMUST00000238967.2 Secreted, extracellular space, extracellular matrix (from UniProt A0A5F8MPH8) A0A5F8MPH8 A0A5F8MPH8_MOUSE ENSMUST00000238967.1 NM_001428336 Tnxb uc294jot.1 uc294jot.2 Secreted, extracellular space, extracellular matrix Belongs to the tenascin family. uc294jot.1 uc294jot.2 
ENSMUST00000238968.2 Mical3 ENSMUST00000238968.2 Reaction=H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl- (R)-S-oxide-[F-actin] + NADP(+); Xref=Rhea:RHEA:51308, Rhea:RHEA- COMP:12953, Rhea:RHEA-COMP:12956, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16044, ChEBI:CHEBI:45764, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.225; Evidence=; (from UniProt A0A5F8MPU7) A0A5F8MPU7 A0A5F8MPU7_MOUSE BC043122 ENSMUST00000238968.1 Mical3 uc294jou.1 uc294jou.2 Reaction=H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl- (R)-S-oxide-[F-actin] + NADP(+); Xref=Rhea:RHEA:51308, Rhea:RHEA- COMP:12953, Rhea:RHEA-COMP:12956, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16044, ChEBI:CHEBI:45764, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.225; Evidence=; Cytoplasm Belongs to the Mical family. uc294jou.1 uc294jou.2 
ENSMUST00000238969.2 Amd1 ENSMUST00000238969.2 S-adenosylmethionine decarboxylase 1 (from RefSeq NM_009665.5) DCAM1_MOUSE ENSMUST00000238969.1 NM_009665 P0DMN7 P31154 P82184 Q58E47 uc294jov.1 uc294jov.2 Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. Reaction=H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3- (methylsulfanyl)propylamine; Xref=Rhea:RHEA:15981, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57443, ChEBI:CHEBI:59789; EC=4.1.1.50; Evidence=; Name=pyruvate; Xref=ChEBI:CHEBI:15361; Note=Binds 1 pyruvoyl group covalently per subunit.; Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1. Heterotetramer of two alpha and two beta chains. P0DMN7; P98083: Shc1; NbExp=7; IntAct=EBI-644529, EBI-300201; Expressed in embryonic stem cells; subsequently down-regulated in differentiating neural precursor cells. Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. Embryonic lethal with developmental arrest between E3.5 and E6.5. Arrest of blastocysts cultured in vitro is rescued by the addition of spermidine. Belongs to the eukaryotic AdoMetDC family. in utero embryonic development adenosylmethionine decarboxylase activity protein binding cytosol S-adenosylmethioninamine biosynthetic process polyamine biosynthetic process spermine biosynthetic process spermidine biosynthetic process lyase activity carboxy-lyase activity putrescine binding uc294jov.1 uc294jov.2 
ENSMUST00000238972.2 Tafa2 ENSMUST00000238972.2 TAFA chemokine like family member 2, transcript variant 2 (from RefSeq NM_001252387.1) ENSMUST00000238972.1 Fam19a2 NM_001252387 Q5M9Q3 Q7TPG7 TAFA2_MOUSE uc294joy.1 uc294joy.2 This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]. Has a role as neurotrophic factor involved in neuronal survival and neurobiological functions. Cytoplasm Nucleus Mainly expressed in different brain regions, including cortex, amygdala and hippocampus (at protein level) (PubMed:30137205). Expressed by neurons and astrocytes (PubMed:30137205). Expressed as early as 13.5 dpc, increases and peaks at 2 weeks after birth and is highly expressed until adulthood. Mutant mice grow and develop normally but exhibit impairments in spatial learning and memory and impairments in short- and long-term memory, accompanied with increased level of anxiety-like behaviors in open-field test. They also show decreased level of depression-like behaviors in forced-swim test and tail- suspension test (PubMed:30137205). They show neuronal loss, defects in dendritic and synaptic morphology, and apoptosis in the brain (PubMed:30137205). Belongs to the TAFA family. Sequence=AAH27082.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; extracellular space nucleus cytoplasm signal transduction memory visual learning receptor agonist activity uc294joy.1 uc294joy.2 
ENSMUST00000238973.2 Cib3 ENSMUST00000238973.2 calcium and integrin binding family member 3, transcript variant 1 (from RefSeq NM_001411781.1) A0A5F8MPX9 A0A5F8MPX9_MOUSE Cib3 ENSMUST00000238973.1 NM_001411781 uc294joz.1 uc294joz.2 uc294joz.1 uc294joz.2 
ENSMUST00000238978.2 Kctd11 ENSMUST00000238978.2 potassium channel tetramerisation domain containing 11 (from RefSeq NM_153143.4) ENSMUST00000238978.1 KCD11_MOUSE NM_153143 Q8K485 Ren uc294jpe.1 uc294jpe.2 Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin- dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down- regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. Protein modification; protein ubiquitination. Homopentamer. Interacts with KCTD6 and KCTD21; KCTD11 and KCTD6 or KCTD21 may associate in pentameric assemblies. Component of the BCR(KCTD11) E3 ubiquitin ligase complex, at least composed of CUL3 and KCTD11 and RBX1. Interacts (via BTB domain) with CUL3; initially a 4:4 stoichiometry has been reported, however, electron microscopy revealed pentameric states of the BTB domain. Weakly expressed in lung. In the cerebellum, higher expression in non proliferating external granule cells layer than in highly proliferating ones. Detected at 7.5 dpc in neuroectodermal cells, and later in neural crest, in ventral region of the spinal cord and in ventricular epithelium of the neural tube. The BTB domain is required for growth-suppressing properties. Overexpression of Kctd11 by lentiviral vector injection inhibits xenograft tumor growth in athymic nude mice. cytoplasm cell cycle multicellular organism development nervous system development negative regulation of neuroblast proliferation protein ubiquitination transferase activity cell differentiation regulation of growth regulation of cell proliferation identical protein binding positive regulation of neuron differentiation negative regulation of smoothened signaling pathway protein homooligomerization uc294jpe.1 uc294jpe.2 
ENSMUST00000238986.2 Bricd5 ENSMUST00000238986.2 Bricd5 (from geneSymbol) A0A5F8MPL8 A0A5F8MPL8_MOUSE AK079437 Bricd5 ENSMUST00000238986.1 uc294jpl.1 uc294jpl.2 uc294jpl.1 uc294jpl.2 
ENSMUST00000238987.2 Asb14 ENSMUST00000238987.2 ankyrin repeat and SOCS box-containing 14, transcript variant 1 (from RefSeq NM_001170748.2) A0A5F8MPW7 A0A5F8MPW7_MOUSE Asb14 ENSMUST00000238987.1 NM_001170748 uc294jpm.1 uc294jpm.2 Protein modification; protein ubiquitination. Belongs to the ankyrin SOCS box (ASB) family. uc294jpm.1 uc294jpm.2 
ENSMUST00000238996.2 Cimap1b ENSMUST00000238996.2 ciliary microtubule associated protein 1B, transcript variant 3 (from RefSeq NM_001402877.1) A0A5F8MPV5 A0A5F8MPV5_MOUSE Cimap1b ENSMUST00000238996.1 NM_001402877 Odf3b uc294jpv.1 uc294jpv.2 uc294jpv.1 uc294jpv.2 
ENSMUST00000239000.2 Nrg1 ENSMUST00000239000.2 Nrg1 (from geneSymbol) A0A5F8MPU8 A0A5F8MPU8_MOUSE ENSMUST00000239000.1 Nrg1 uc294jpz.1 uc294jpz.2 uc294jpz.1 uc294jpz.2 
ENSMUST00000239002.2 Nccrp1 ENSMUST00000239002.2 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) (from RefSeq NM_001081115.2) ENSMUST00000239002.1 FBX50_MOUSE Fbxo50 G3X9C2 NM_001081115 Q8BT24 uc294jqb.1 uc294jqb.2 Promotes cell proliferation. Cytoplasm Strongly expressed in kidney. Weakly expressed in stomach, colon, duodenum and prostate. Sequence=EDL24129.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; cytoplasm glycoprotein catabolic process positive regulation of cell proliferation protein ubiquitination SCF ubiquitin ligase complex ER-associated ubiquitin-dependent protein catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin protein ligase activity uc294jqb.1 uc294jqb.2 
ENSMUST00000239007.2 Cfap144 ENSMUST00000239007.2 Belongs to the CFAP144 family. (from UniProt D2D553) BC048748 D2D553 D2D553_MOUSE ENSMUST00000239007.1 Fam183b Theg6 uc294jqg.1 uc294jqg.2 Belongs to the CFAP144 family. uc294jqg.1 uc294jqg.2 
ENSMUST00000239008.2 Tmem178b ENSMUST00000239008.2 transmembrane protein 178B, transcript variant 1 (from RefSeq NM_001360978.1) A0A5F8MQ13 A0A5F8MQ13_MOUSE ENSMUST00000239008.1 NM_001360978 Tmem178b uc294jqh.1 uc294jqh.2 Belongs to the TMEM178 family. uc294jqh.1 uc294jqh.2 
ENSMUST00000239011.2 Septin4 ENSMUST00000239011.2 septin 4, transcript variant 11 (from RefSeq NM_001424196.1) A0A5F8MP96 A0A5F8MP96_MOUSE ENSMUST00000239011.1 NM_001424196 Septin4 uc294jqk.1 uc294jqk.2 Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. uc294jqk.1 uc294jqk.2 
ENSMUST00000239017.2 Klc1 ENSMUST00000239017.2 Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport. (from UniProt A0A5F8MPZ2) A0A5F8MPZ2 A0A5F8MPZ2_MOUSE AK031309 ENSMUST00000239017.1 Klc1 uc294jqq.1 uc294jqq.2 Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport. Oligomeric complex composed of two heavy chains and two light chains. Cytoplasm, cytoskeleton Belongs to the kinesin light chain family. uc294jqq.1 uc294jqq.2 
ENSMUST00000239023.2 Gm38999 ENSMUST00000239023.2 predicted gene, 38999 (from RefSeq NM_001370852.1) CS084_MOUSE ENSMUST00000239023.1 Gm38999 Gm52993 H3BKT1 NM_001370852 uc294jqw.1 uc294jqw.2 uc294jqw.1 uc294jqw.2 
ENSMUST00000239029.2 Ermap ENSMUST00000239029.2 erythroblast membrane-associated protein, transcript variant 1 (from RefSeq NM_013848.3) ENSMUST00000239029.1 ERMAP_MOUSE NM_013848 Q3UV82 Q6P4T5 Q8CEH1 Q9JLN5 uc294jrc.1 uc294jrc.2 Possible role as a cell-adhesion or receptor molecule of erythroid cells. Cell membrane ; Single-pass type I membrane protein Cytoplasm Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9JLN5-1; Sequence=Displayed; Name=2; IsoId=Q9JLN5-2; Sequence=VSP_017425, VSP_017427; Name=3; IsoId=Q9JLN5-3; Sequence=VSP_017426; Expressed in spleen and bone marrow. First detected at 11 dpc. Expressed in fetal liver at 12.5 dpc and 13.5 dpc. Glycosylated. Belongs to the immunoglobulin superfamily. BTN/MOG family. Sequence=AAF31162.1; Type=Erroneous initiation; Evidence=; Sequence=AAH63257.1; Type=Erroneous initiation; Evidence=; Sequence=BAE23390.1; Type=Erroneous initiation; Evidence=; receptor binding cytoplasm plasma membrane external side of plasma membrane membrane integral component of membrane cytoplasmic vesicle regulation of immune response T cell receptor signaling pathway uc294jrc.1 uc294jrc.2 
ENSMUST00000239037.2 A930007A09Rik ENSMUST00000239037.2 RIKEN cDNA A930007A09 gene (from RefSeq NM_001357954.1) A0A668KM50 A0A668KM50_MOUSE A930007A09Rik ENSMUST00000239037.1 NM_001357954 uc294jrk.1 uc294jrk.2 uc294jrk.1 uc294jrk.2 
ENSMUST00000239046.2 Fam90a1b ENSMUST00000239046.2 family with sequence similarity 90, member A1B (from RefSeq NM_001362881.1) A0A5F8MPE6 CX058_MOUSE ENSMUST00000239046.1 NM_001362881 uc294jrr.1 uc294jrr.2 uc294jrr.1 uc294jrr.2 
ENSMUST00000239047.2 Gm57504 ENSMUST00000239047.2 Gm57504 (from geneSymbol) AK138949 ENSMUST00000239047.1 uc294jrs.1 uc294jrs.2 uc294jrs.1 uc294jrs.2 
ENSMUST00000239049.2 Kcnip2 ENSMUST00000239049.2 Kv channel-interacting protein 2, transcript variant e (from RefSeq NM_001424873.1) A0A5F8MPB0 A0A5F8MPB0_MOUSE ENSMUST00000239049.1 Kcnip2 NM_001424873 uc294jru.1 uc294jru.2 uc294jru.1 uc294jru.2 
ENSMUST00000239050.2 1700028K03Rik ENSMUST00000239050.2 Plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC) thereby stabilizing SC, ensuring progression of meiotic prophase I in male and female germ cells (PubMed:30949703). Promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1 (PubMed:30746471). Required for the localization of TEX11 and MSH4 to recombination intermediates (PubMed:30746471). (from UniProt Q3KQP7) AK006463 ENSMUST00000239050.1 G3X9D1 Q3KQP7 Q8CF32 SPO16_MOUSE Scre Spo16 uc294jrv.1 uc294jrv.2 Plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC) thereby stabilizing SC, ensuring progression of meiotic prophase I in male and female germ cells (PubMed:30949703). Promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1 (PubMed:30746471). Required for the localization of TEX11 and MSH4 to recombination intermediates (PubMed:30746471). Homooligomer (PubMed:30949703). Interacts with SHOC1 (PubMed:30746471). Interacts with SYCP1 and SYCE3 (PubMed:30949703). Chromosome Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3KQP7-1; Sequence=Displayed; Name=2; IsoId=Q3KQP7-2; Sequence=VSP_027516, VSP_027517; Testis (at protein level). Expressed in embryonic ovaries at embryonic day 16.5 (at protein level). Mice show a massive germline loss and infertility in both males and females (PubMed:30746471, PubMed:30949703). Defects in meiotic prophase progression and meiotic recombination seen in spermatocytes and oocytes (PubMed:30746471). Meiocytes fail to achieve complete synapsis and show repair of double-strand breaks without formation of crossovers (PubMed:30746471). Sequence=BAC25144.1; Type=Frameshift; Evidence=; molecular_function cellular_component biological_process uc294jrv.1 uc294jrv.2 
ENSMUST00000239056.2 Shc3 ENSMUST00000239056.2 src homology 2 domain-containing transforming protein C3 (from RefSeq NM_009167.5) A0A5F8MPM1 A0A5F8MPM1_MOUSE ENSMUST00000239056.1 NM_009167 Shc3 mCG_1275 uc294jsb.1 uc294jsb.2 uc294jsb.1 uc294jsb.2 
ENSMUST00000239057.2 Cyp2d13 ENSMUST00000239057.2 Cyp2d13 (from geneSymbol) ENSMUST00000239057.1 NR_190749 uc294jsc.1 uc294jsc.2 uc294jsc.1 uc294jsc.2 
ENSMUST00000239076.2 Gm53012 ENSMUST00000239076.2 General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages. (from UniProt Q8R092) AK051238 CA043_MOUSE ENSMUST00000239076.1 Q3UBD8 Q8BII4 Q8BIP7 Q8R092 Q8R240 Q9CV59 Q9CYB6 uc294jsv.1 uc294jsv.2 General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages. Membrane ; Single-pass membrane protein Golgi apparatus Mitochondrion Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R092-3; Sequence=Displayed; Name=2; IsoId=Q8R092-1; Sequence=VSP_014423, VSP_014424; Name=3; IsoId=Q8R092-2; Sequence=VSP_014422; N-terminal region is required for phagocytosis of Gram negative bacterium. in utero embryonic development molecular_function cellular_component membrane integral component of membrane uc294jsv.1 uc294jsv.2 
ENSMUST00000239091.2 Tns3 ENSMUST00000239091.2 Cell junction, focal adhesion (from UniProt A0A5F8MP98) A0A5F8MP98 A0A5F8MP98_MOUSE BC172603 ENSMUST00000239091.1 Tns3 uc294jtk.1 uc294jtk.2 Cell junction, focal adhesion Belongs to the PTEN phosphatase protein family. uc294jtk.1 uc294jtk.2 
ENSMUST00000239099.2 Eef1akmt1 ENSMUST00000239099.2 EEF1A alpha lysine methyltransferase 1 (from RefSeq NM_026526.3) EFMT1_MOUSE ENSMUST00000239099.1 Eef1akmt1 N6amt2 NM_026526 Q9CQR0 Q9CY45 uc294jts.1 uc294jts.2 Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'. Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; Evidence=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54193; Evidence=; Cytoplasm Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family. Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. Sequence=AAH51925.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB23947.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAB28017.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; nucleic acid binding cytoplasm methyltransferase activity protein-lysine N-methyltransferase activity transferase activity peptidyl-lysine methylation methylation uc294jts.1 uc294jts.2 
ENSMUST00000239110.2 Or51f23b ENSMUST00000239110.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein (from UniProt A0A1B0GSU5) A0A1B0GSU5 A0A1B0GSU5_MOUSE AK028467 ENSMUST00000239110.1 Olfr560 Or51f23b uc294juc.1 uc294juc.2 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the G-protein coupled receptor 1 family. G-protein coupled receptor activity olfactory receptor activity plasma membrane signal transduction G-protein coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane response to stimulus detection of chemical stimulus involved in sensory perception of smell uc294juc.1 uc294juc.2 
ENSMUST00000239112.3 Qtrt2 ENSMUST00000239112.3 queuine tRNA-ribosyltransferase accessory subunit 2, transcript variant 6 (from RefSeq NM_001405418.1) A9C446 B8ZXI1 ENSMUST00000239112.1 ENSMUST00000239112.2 NM_001405418 Q5XK35 QTRT2_MOUSE Qtrt2 Qtrtd1 uc294jue.1 uc294jue.2 uc294jue.3 Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= Note=Binds 1 zinc ion per subunit. Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2. Cytoplasm tochondrion outer membrane ; Peripheral membrane protein ytoplasmic side te=May associate with the mitochondrion outer membrane. Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Qv1; IsoId=B8ZXI1-1; Sequence=Displayed; Name=2; Synonyms=Qv0; IsoId=B8ZXI1-2; Sequence=VSP_038046; Expressed in brain, heart, kidney, liver, lung, skeletal muscle, spleen and testis. [Isoform 1]: Major isoform in adult tissues. Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. Sequence=CAP19252.1; Type=Erroneous initiation; Evidence=; Sequence=CAX17683.1; Type=Erroneous initiation; Evidence=; Sequence=EDK98022.1; Type=Erroneous initiation; Evidence=; Sequence=EDK98023.1; Type=Erroneous initiation; Evidence=; protein binding cytoplasm mitochondrion mitochondrial outer membrane tRNA modification tRNA processing zinc ion binding queuine tRNA-ribosyltransferase activity membrane transferase activity, transferring pentosyl groups macromolecular complex protein homodimerization activity metal ion binding protein heterodimerization activity tRNA-guanine transglycosylation uc294jue.1 uc294jue.2 uc294jue.3 
ENSMUST00000239113.2 Gla ENSMUST00000239113.2 galactosidase, alpha, transcript variant 2 (from RefSeq NR_175282.1) ENSMUST00000239113.1 Gla NR_175282 Q8BGZ6 Q8BGZ6_MOUSE uc294juf.1 uc294juf.2 Homodimer. Lysosome Belongs to the glycosyl hydrolase 27 family. catalytic activity hydrolase activity, hydrolyzing O-glycosyl compounds alpha-galactosidase activity receptor binding extracellular region cytoplasm lysosome Golgi apparatus carbohydrate metabolic process metabolic process oligosaccharide metabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds galactoside binding protein homodimerization activity uc294juf.1 uc294juf.2 
ENSMUST00000239116.2 Gm52965 ENSMUST00000239116.2 Gm52965 (from geneSymbol) AK139128 ENSMUST00000239116.1 uc294jui.1 uc294jui.2 uc294jui.1 uc294jui.2 
ENSMUST00000239119.2 Lonrf1 ENSMUST00000239119.2 LON peptidase N-terminal domain and ring finger 1 (from RefSeq NM_001081150.2) D3YY23 ENSMUST00000239119.1 LONF1_MOUSE NM_001081150 uc294jul.1 uc294jul.2 metal ion binding uc294jul.1 uc294jul.2 
ENSMUST00000239120.2 Agap2 ENSMUST00000239120.2 Belongs to the centaurin gamma-like family. (from UniProt A0A5F8MPB7) A0A5F8MPB7 A0A5F8MPB7_MOUSE AK147446 Agap2 ENSMUST00000239120.1 uc294jum.1 uc294jum.2 Belongs to the centaurin gamma-like family. uc294jum.1 uc294jum.2 
ENSMUST00000239125.2 Arl5b ENSMUST00000239125.2 Belongs to the small GTPase superfamily. Arf family. (from UniProt Q6NXZ5) Arl5b Arl8 BC066810 ENSMUST00000239125.1 Q6NXZ5 Q6NXZ5_MOUSE uc294jur.1 uc294jur.2 Belongs to the small GTPase superfamily. Arf family. nucleotide binding GTP binding protein localization to Golgi membrane uc294jur.1 uc294jur.2 
ENSMUST00000239130.2 Gm14137 ENSMUST00000239130.2 predicted gene 14137 (from RefSeq NM_001039223.4) CO062_MOUSE ENSMUST00000239130.1 NM_001039223 Q8CE97 uc294juw.1 uc294juw.2 Mitochondrion Sequence=BAC26099.1; Type=Erroneous initiation; Evidence=; Sequence=CAM45944.1; Type=Erroneous initiation; Evidence=; cytoplasm mitochondrion plasma membrane Rho protein signal transduction regulation of cell shape GTP-Rho binding positive regulation of actin filament polymerization positive regulation of pseudopodium assembly uc294juw.1 uc294juw.2 
ENSMUST00000239135.2 Muc12 ENSMUST00000239135.2 Lacks conserved residue(s) required for the propagation of feature annotation. (from UniProt A0A5F8MPQ6) A0A5F8MPQ6 A0A5F8MPQ6_MOUSE ENSMUST00000239135.1 Gm31160 Muc12 uc294jvb.1 uc294jvb.2 Lacks conserved residue(s) required for the propagation of feature annotation. uc294jvb.1 uc294jvb.2 
ENSMUST00000239146.2 Ptk2 ENSMUST00000239146.2 PTK2 protein tyrosine kinase 2, transcript variant 4 (from RefSeq NM_001358046.1) A0A5F8MPY3 A0A5F8MPY3_MOUSE ENSMUST00000239146.1 NM_001358046 Ptk2 uc294jvm.1 uc294jvm.2 Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=; Cell junction, focal adhesion Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cell cortex Cytoplasm, cytoskeleton, cilium basal body Membrane ; Peripheral membrane protein ; Cytoplasmic side uc294jvm.1 uc294jvm.2 
ENSMUST00000239150.3 Xbp1 ENSMUST00000239150.3 X-box binding protein 1, transcript variant 2 (from RefSeq NM_001271730.1) ENSMUST00000239150.1 ENSMUST00000239150.2 NM_001271730 O35426 Q8VHM0 Q922G5 Q9ESS3 Treb5 XBP1_MOUSE Xbp1 uc294jvq.1 uc294jvq.2 uc294jvq.3 Functions as a transcription factor during endoplasmic reticulum stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development and the development of secretory tissues such as exocrine pancreas and salivary gland (PubMed:10425189, PubMed:10652269, PubMed:16362047, PubMed:17612490). Involved in differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (By similarity). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions (PubMed:23529610). Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (PubMed:15486293). [Isoform 1]: Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production. In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 production in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (By similarity). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16332684). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (PubMed:12902539). Acts as a weak transcriptional factor. Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress. Binds to the ER stress response element (ERSE) upon ER stress. Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences. Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE). Associates preferentially to the HDAC3 gene promoter region in a static flow- dependent manner. Binds to the CDH5/VE-cadherin gene promoter region (By similarity). [Isoform 2]: Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11850408, PubMed:14559994). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation, and promotes as well membrane phospholipid biosynthesis necessary for ER expansion (PubMed:12612580, PubMed:17213183). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta- catenin nuclear translocation and E2F2 gene expression. Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions. Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation. Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (By similarity). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation (PubMed:23623498, PubMed:25223794). Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells (PubMed:12902539, PubMed:24753614). Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance (PubMed:20348926). Improves also glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels (PubMed:21317886). Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR- independent manner (PubMed:18556558). Binds to the 5'-CCACG-3' motif in the PPARG promoter (PubMed:25223794). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner. Binds to the BECN1 gene promoter region. Binds to the CDH5/VE-cadherin gene promoter region. Binds to the ER stress response element (ERSE) upon ER stress (By similarity). Isoform 1 interacts with HM13. Isoform 1 interacts with RNF139; the interaction induces ubiquitination and degradation of isoform 1. Isoform 1 interacts (via luminal domain) with DERL1; the interaction obviates the need for ectodomain shedding prior HM13/SPP- mediated XBP1 isoform 1 cleavage. Isoform 1 interacts with isoform 2; the interaction sequesters isoform 2 from the nucleus and enhances isoform 2 degradation in the cytoplasm. Isoform 1 interacts with HDAC3 and AKT1; the interactions occur in endothelial cell (EC) under disturbed flow. Isoform 1 interacts with the oncoprotein FOS. Isoform 2 interacts with ATF6; the interaction occurs in a ER stress-dependent manner and is required for DNA binding to the unfolded protein response element (UPRE). Isoform 2 interacts with PIK3R1; the interaction is direct and induces translocation of XBP1 isoform 2 into the nucleus and the unfolded protein response (UPR) XBP1-dependent target genes activation in a ER stress- and/or insulin-dependent but PI3K- independent manner (By similarity). Isoform 2 interacts with SIRT1 (PubMed:20955178). Isoform 2 interacts with PIK3R1 and PIK3R2; the interactions are direct and induce translocation of XBP1 isoform 2 into the nucleus and the unfolded protein response (UPR) XBP1-dependent target genes activation in a ER stress- and/or insulin-dependent but PI3K-independent manner (PubMed:20348926). Isoform 2 interacts with FOXO1; the interaction is direct and leads to FOXO1 ubiquitination and degradation via the proteasome pathway in hepatocytes (PubMed:21317886). Endoplasmic reticulum Note=Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (By similarity). [Isoform 1]: Nucleus Cytoplasm Endoplasmic reticulum membrane ; Single- pass type II membrane protein Endoplasmic reticulum membrane ; Peripheral membrane protein Membrane ; Peripheral membrane protein Note=Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localizes predominantly at the endoplasmic reticulum membrane as a membrane-spanning protein; whereas may be only marginally localized on the cytosolic side of the ER membrane as a peripheral membrane (By similarity). Shows no preferential localization to either the nucleus or the cytoplasm (PubMed:16332684). [Isoform 2]: Nucleus toplasm Note=Localizes predominantly in the nucleus (PubMed:16332684). Colocalizes in the nucleus with SIRT1 (PubMed:20955178). Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin-dependent manner (PubMed:20348926). [X-box-binding protein 1, cytoplasmic form]: Cytoplasm Nucleus Note=Localizes in the cytoplasm and nucleus after HM13/SPP-mediated intramembranaire proteolytic cleavage of isoform 1 (By similarity). Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Unprocessed XBP-1, XBP-1U ; IsoId=O35426-1; Sequence=Displayed; Name=2; Synonyms=Processed XBP-1, XBP-1S ; IsoId=O35426-2; Sequence=VSP_012937; Isoform 1 and isoform 2 are expressed at higher level in branch curves of vessel walls and in atherosclerotic plaques relative to healthy segments of the same aortas (at protein level) (PubMed:19416856). Expressed in skeletal muscles, plasma cells and pancreatic beta cells (PubMed:17612490). Isoform 1 and isoform 2 are expressed in gonadal adipose tissue. Isoform 1 is expressed in inguinal adipose tissue (PubMed:23623498). Expressed mainly in exocrine glands and bone precursors in the embryonic mouse (PubMed:7693055). Isoform 2 is up-regulated during adipocyte differentiation (PubMed:25223794). Isoform 2 is up-regulated upon refeeding after a fasting period in liver and in ob/ob mice (obese) (at protein level) (PubMed:20348926). Induced by chemical activators of the unfolded protein response (UPR) such as tunicamycin, DTT and thapsigargin (PubMed:17612490). Up-regulated after partial hepatectomy during the acute phase response (PubMed:10652269). Isoform 1 and isoform 2 are up- regulated by interleukin-4 in B cells in a STAT6-dependent manner (PubMed:12612580). Isoform 1 and isoform 2 are up-regulated during lactation and by the lactogenic hormone prolactin (PubMed:23623498). Isoform 2 is up-regulated by prolonged feeding of high-carbohydrate diets in hepatocytes in absence of ER-stress (PubMed:18556558). Isoform 2 is up-regulated by insulin-like growth factor and glucose starvation (PubMed:17612490). Isoform 2 is up-regulated during plasma-cell differentiation in response to endoplasmic reticulum (ER) stress, such as lipopolysaccharide (LPS) (PubMed:11780124, PubMed:11850408, PubMed:12612580). Isoform 1 transmembrane signal-anchor domain is necessary for its own mRNA to be recruited to the endoplasmic reticulum (ER) which will undergo unconventional ERN1-dependent splicing in response to ER stress. Isoform 1 N-terminus and C-terminus regions are necessary for DNA-binding and weak transcriptional activity, respectively. Isoform 2 N-terminus and C-terminus regions are necessary for DNA-binding and strong transcriptional activity upon ER stress, respectively. Isoform 2 C-terminus region contains a nuclear exclusion signal (NES) at positions 182 through 204. Isoform 2 C-terminus region contains a degradation domain at positions 204 through 256 (By similarity). Isoform 1 and isoform 2 N-terminus domains are necessary for nuclear localization targeting. Isoform 1 C-terminus domain confers localization to the cytoplasm and is sufficient to impose rapid degradation (PubMed:16332684). [Isoform 2]: Acetylated by EP300; acetylation positively regulates the transcriptional activity of XBP1 isoform 2 (PubMed:20955178). Isoform 2 is deacetylated by SIRT1; deacetylation negatively regulates the transcriptional activity of XBP1 isoform 2 (PubMed:20955178). [Isoform 1]: Ubiquitinated, leading to proteasomal degradation in response to ER stress (PubMed:11780124, PubMed:12902539, PubMed:16332684). X-box-binding protein 1, cytoplasmic form and luminal form are produced by intramembrane proteolytic cleavage of ER membrane-anchored isoform 1 triggered by HM13/SPP in a DERL1-RNF139-dependent and VCP/p97-independent manner. X-box-binding protein 1, luminal form is ubiquitinated leading to proteasomal degradation (By similarity). Mice embryos die at 12.5-13.5 dpc and display less blood vessels (PubMed:23529610). Embryos display hypoplastic livers, cellular necrosis in the myocardium, hypoplasia of the heart and die in utero from severe anemia (PubMed:10425189, PubMed:10652269). Mice display severe abnormalities in the development and function of secretory cells, such as plasma B cells and pancreatic acinar cells (PubMed:16362047). Haploinsufficient mice fed a high-fat diet gain more weight, display enhanced ER stress in adipose tissue, reduced insulin receptor signaling and develop peripheral insulin resistance and type 2 diabetes (PubMed:15486293). Endothelial-specific knockout mice show delayed retinal vascular development and impaired postischemic angiogenesis (PubMed:23529610, PubMed:23184933). Dopaminergic neuron- specific knockout mice display ER dysfonction and accumulation of abnormal protein aggregates (PubMed:24753614). Liver-specific knockout mice leads to reduced lipogenic gene expression and diminished hepatic lipid synthesis (PubMed:18556558). Adipocyte-specific knockout female mice fed with a regular or high-fat diet, show no alteration in body weight, adipose tissue mass, blood glucose, serum insulin and lipid levels; however during lactation adipose tissue mass increases and milk production decreases but mammary gland structure and milk composition remains normal (PubMed:23623498). Intestinal epithelial cell-specific knockout mice born and developed normally but displayed small intestinal mucosal inflammation in association with increased ER stress, a diminution of Paneth and goblet cells with reduced secretory granules (PubMed:18775308). [Isoform 2]: Potent transcriptional activator. Induced by unconventional ERN1-dependent splicing in response to endoplasmic reticulum stress. ERN1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript (PubMed:11780124, PubMed:11850408). Belongs to the bZIP family. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding angiogenesis regulation of cell growth liver development positive regulation of protein phosphorylation endothelial cell proliferation protease binding epithelial cell maturation positive regulation of immunoglobulin production DNA binding transcription factor activity, sequence-specific DNA binding nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter ubiquitin-dependent protein catabolic process lipid metabolic process autophagy apoptotic process response to unfolded protein positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response multicellular organism development muscle organ development positive regulation of cell proliferation regulation of autophagy positive regulation of autophagy negative regulation of myotube differentiation phosphatidylinositol 3-kinase signaling protein transport membrane integral component of membrane protein kinase binding cell differentiation integral component of endoplasmic reticulum membrane positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway endoplasmic reticulum unfolded protein response exocrine pancreas development positive regulation of histone methylation chromatin DNA binding ubiquitin protein ligase binding regulation of protein stability protein destabilization cellular response to nutrient positive regulation of TOR signaling cellular response to insulin stimulus cellular response to oxidative stress response to endoplasmic reticulum stress cellular triglyceride homeostasis positive regulation of vascular wound healing cellular response to vascular endothelial growth factor stimulus phosphatidylinositol 3-kinase regulatory subunit binding cellular response to glucose starvation positive regulation of protein import into nucleus response to drug glucose homeostasis cholesterol homeostasis histone deacetylase binding negative regulation of apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding ubiquitin-like protein ligase binding positive regulation of MHC class II biosynthetic process positive regulation of B cell differentiation positive regulation of T cell differentiation positive regulation of fat cell differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity vascular endothelial growth factor receptor signaling pathway neuron development positive regulation of immunoglobulin secretion response to electrical stimulus fatty acid homeostasis sterol homeostasis serotonin secretion, neurotransmission negative regulation of pathway-restricted SMAD protein phosphorylation adipose tissue development epithelial cell maturation involved in salivary gland development intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress negative regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to fructose stimulus cellular response to glucose stimulus cellular response to interleukin-4 cellular response to peptide hormone stimulus cellular response to fluid shear stress cellular response to laminar fluid shear stress presynapse positive regulation of plasma cell differentiation negative regulation of endoplasmic reticulum unfolded protein response positive regulation of endoplasmic reticulum unfolded protein response positive regulation of proteasomal protein catabolic process positive regulation of protein acetylation negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of lactation response to insulin-like growth factor stimulus cellular response to leukemia inhibitory factor positive regulation of hepatocyte proliferation positive regulation of endothelial cell apoptotic process positive regulation of interleukin-6 secretion uc294jvq.1 uc294jvq.2 uc294jvq.3 
ENSMUST00000239158.2 Myadml2 ENSMUST00000239158.2 myeloid-associated differentiation marker-like 2, transcript variant 1 (from RefSeq NM_026751.1) ENSMUST00000239158.1 MADL2_MOUSE NM_026751 Q08AU7 Q5BKP1 Q9D1F1 uc294jvx.1 uc294jvx.2 Membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q08AU7-1; Sequence=Displayed; Name=2; IsoId=Q08AU7-2; Sequence=VSP_033351, VSP_033352; Belongs to the MAL family. Sequence=AAH91000.1; Type=Erroneous initiation; Evidence=; Sequence=AAI09330.1; Type=Erroneous initiation; Evidence=; Sequence=AAI25009.1; Type=Erroneous initiation; Evidence=; molecular_function cytoplasm biological_process membrane integral component of membrane uc294jvx.1 uc294jvx.2 
ENSMUST00000239173.2 ENSMUSG00000121862 ENSMUST00000239173.2 ENSMUSG00000121862 (from geneSymbol) ENSMUST00000239173.1 uc288unu.1 uc288unu.1 
ENSMUST00000239177.2 Mast2 ENSMUST00000239177.2 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; (from UniProt A0A668KL31) A0A668KL31 A0A668KL31_MOUSE BC060703 ENSMUST00000239177.1 Mast2 uc288uny.1 Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. uc288uny.1 
ENSMUST00000239185.2 Gm7582 ENSMUST00000239185.2 Membrane ; Multi- pass membrane protein (from UniProt A0A668KLA7) A0A668KLA7 A0A668KLA7_MOUSE ENSMUST00000239185.1 Gm7582 uc288uog.1 Membrane ; Multi- pass membrane protein uc288uog.1 
ENSMUST00000239195.2 Gm15433 ENSMUST00000239195.2 Membrane ; Multi- pass membrane protein (from UniProt A0A668KLD8) A0A668KLD8 A0A668KLD8_MOUSE ENSMUST00000239195.1 Gm15433 uc288uoq.1 Membrane ; Multi- pass membrane protein uc288uoq.1 
ENSMUST00000239205.2 A630031M04Rik ENSMUST00000239205.2 A630031M04Rik (from geneSymbol) AK039749 ENSMUST00000239205.1 uc288upa.1 uc288upa.1 
ENSMUST00000239206.2 Gm3858 ENSMUST00000239206.2 Gm3858 (from geneSymbol) A0A668KLC8 A0A668KLC8_MOUSE ENSMUST00000239206.1 Gm3858 uc288upb.1 uc288upb.1 
ENSMUST00000239223.2 Adgrf2 ENSMUST00000239223.2 Membrane ; Multi- pass membrane protein (from UniProt A0A668KM90) A0A668KM90 A0A668KM90_MOUSE AK142836 Adgrf2 ENSMUST00000239223.1 uc288upr.1 Membrane ; Multi- pass membrane protein Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. uc288upr.1 
ENSMUST00000239228.2 Gm34637 ENSMUST00000239228.2 predicted gene, 34637 (from RefSeq NR_136889.1) ENSMUST00000239228.1 NR_136889 uc288upw.1 uc288upw.1 
ENSMUST00000239231.2 Gm56303 ENSMUST00000239231.2 Gm56303 (from geneSymbol) A0A668KLB6 A0A668KLB6_MOUSE ENSMUST00000239231.1 Gm56303 uc288upz.1 uc288upz.1 
ENSMUST00000239238.2 Mycbpap ENSMUST00000239238.2 MYCBP associated protein, transcript variant 1 (from RefSeq NM_001415760.1) A0A668KL73 A0A668KL73_MOUSE ENSMUST00000239238.1 Mycbpap NM_001415760 uc288uqg.1 uc288uqg.1 
ENSMUST00000239240.2 Stambpl1 ENSMUST00000239240.2 STAM binding protein like 1, transcript variant 2 (from RefSeq NM_001360716.1) Amshlp ENSMUST00000239240.1 NM_001360716 Q76LY0 Q76N33 Q8VEK5 STALP_MOUSE uc288uqi.1 Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex. Does not cleave 'Lys-48'-linked polyubiquitin chains. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit. ; Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=AMSH-FPalpha, ALM alpha; IsoId=Q76N33-1; Sequence=Displayed; Name=2; Synonyms=AMSH-FPbeta, ALM beta; IsoId=Q76N33-2; Sequence=VSP_014649; Ubiquitously expressed. Isoform 1 is widely expressed while isoform 2 is testis-specific. The JAMM motif is essential for the protease activity. Belongs to the peptidase M67C family. Sequence=AAH18343.1; Type=Erroneous initiation; Evidence=; thiol-dependent ubiquitin-specific protease activity endosome proteolysis peptidase activity metallopeptidase activity membrane protein deubiquitination hydrolase activity metal ion binding Lys63-specific deubiquitinase activity protein K63-linked deubiquitination uc288uqi.1 
ENSMUST00000239249.3 Spata31h-ps1 ENSMUST00000239249.3 predicted gene, 17695, transcript variant 2 (from RefSeq NR_165654.1) ENSMUST00000239249.1 ENSMUST00000239249.2 NR_165654 uc288uqr.1 uc288uqr.2 uc288uqr.1 uc288uqr.2 
ENSMUST00000239259.2 Nkrf ENSMUST00000239259.2 NF-kappaB repressing factor (from RefSeq NM_029891.3) A0A668KL68 A0A668KL68_MOUSE ENSMUST00000239259.1 NM_029891 Nkrf uc288urb.1 Belongs to the CARF family. uc288urb.1 
ENSMUST00000239314.2 Morrbid ENSMUST00000239314.2 Morrbid (from geneSymbol) AK157218 ENSMUST00000239314.1 uc288utd.1 uc288utd.1 
ENSMUST00000239323.2 Pou3f3 ENSMUST00000239323.2 Transcription factor that acts synergistically with SOX11 and SOX4 (By similarity). Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT- 3'). (from UniProt P31361) BC079869 Brn-1 Brn1 ENSMUST00000239323.1 Otf8 P31361 PO3F3_MOUSE uc288utm.1 Transcription factor that acts synergistically with SOX11 and SOX4 (By similarity). Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT- 3'). Homodimer. Nucleus Brain. Expressed in the developing neocortex, both in the late precursor cells and in the migrating neurons. Neonatal death at least 36 hours postpartum. Loss of both Pou3f3 and Pou3f2 leads to abnormal formation of the neocortex with dramatically reduced production of layer IV-II neurons and defective migration of neurons. Can fully replace Pou3f1 in Schwann cells of embryonic mice and rescue peripheral nervous system development in these animals, although severe defects in forebrain development are still observed. Belongs to the POU transcription factor family. Class-3 subfamily. negative regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor activity, sequence-specific DNA binding kidney development DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development nervous system development brain development excretion positive regulation of cell proliferation positive regulation of gene expression cerebral cortex radially oriented cell migration forebrain ventricular zone progenitor cell division negative regulation of apoptotic process sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter chemical homeostasis HMG box domain binding metanephric ascending thin limb development metanephric macula densa development metanephric thick ascending limb development metanephric loop of Henle development metanephric DCT cell differentiation uc288utm.1 
ENSMUST00000239326.2 Asxl3 ENSMUST00000239326.2 Nucleus (from UniProt A0A668KLS4) A0A668KLS4 A0A668KLS4_MOUSE AK082659 Asxl3 ENSMUST00000239326.1 uc288utp.1 Nucleus Belongs to the Asx family. uc288utp.1 
ENSMUST00000239334.4 Gm53019 ENSMUST00000239334.4 Gm53019 (from geneSymbol) ENSMUST00000239334.1 ENSMUST00000239334.2 ENSMUST00000239334.3 uc288utx.1 uc288utx.2 uc288utx.3 uc288utx.1 uc288utx.2 uc288utx.3 
ENSMUST00000239357.2 Snhg5 ENSMUST00000239357.2 Snhg5 (from geneSymbol) ENSMUST00000239357.1 KF876690 uc288uuu.1 uc288uuu.1 
ENSMUST00000239361.2 Gm52955 ENSMUST00000239361.2 Membrane ; Multi- pass membrane protein (from UniProt A0A668KLA6) A0A668KLA6 A0A668KLA6_MOUSE ENSMUST00000239361.1 Gm52955 uc288uuy.1 Membrane ; Multi- pass membrane protein uc288uuy.1 
ENSMUST00000239380.2 Cfhr2 ENSMUST00000239380.2 Lacks conserved residue(s) required for the propagation of feature annotation. (from UniProt A0A668KLU9) A0A668KLU9 A0A668KLU9_MOUSE AK149511 Cfhr2 ENSMUST00000239380.1 uc288uvr.1 Lacks conserved residue(s) required for the propagation of feature annotation. uc288uvr.1 
ENSMUST00000239390.2 ENSMUSG00000121863 ENSMUST00000239390.2 ENSMUSG00000121863 (from geneSymbol) AK015599 ENSMUST00000239390.1 uc288uwb.1 uc288uwb.1 
ENSMUST00000239401.2 Tpgs1 ENSMUST00000239401.2 Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility (PubMed:12242242, PubMed:12972506, PubMed:15890843). May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum. (from UniProt Q99MS8) AK153467 ENSMUST00000239401.1 Gm16517 Gtrgeo22 Q3U5Q9 Q99MS8 Q9R0B5 TPGS1_MOUSE uc288uwm.1 Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility (PubMed:12242242, PubMed:12972506, PubMed:15890843). May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum. Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1 (PubMed:12972506). Interacts with PCM1, CSTPP1 and LRRC49 (By similarity). Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, flagellum basal body Cell projection, axon Cell projection, dendrite Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Associated with microtubules from neurites, centrosomes, basal bodies and axonemes. Broadly expressed at low levels. Highly expressed in brain. Present in brain neurons (at protein level). In testis, expression strongly increases at P22. Male mice are sterile due to defects in the development of the spermatid flagellum. They have reduced body fat content and fail to attack each other when caged together with other males. protein binding cytoplasm centrosome microtubule organizing center cytosol cytoskeleton microtubule cilium chemical synaptic transmission multicellular organism development spermatogenesis sperm axoneme assembly microtubule binding tubulin binding integral component of membrane protein polyglutamylation cell differentiation axon dendrite adult behavior motile cilium cell projection vesicle localization tubulin-glutamic acid ligase activity uc288uwm.1 
ENSMUST00000239409.2 Nrg2 ENSMUST00000239409.2 Membrane ; Single- pass type I membrane protein (from UniProt A0A6I8MWW5) A0A6I8MWW5 A0A6I8MWW5_MOUSE AY227025 ENSMUST00000239409.1 Nrg2 uc288uwu.1 Membrane ; Single- pass type I membrane protein Belongs to the neuregulin family. Lacks conserved residue(s) required for the propagation of feature annotation. uc288uwu.1 
ENSMUST00000239415.2 Pou2af3 ENSMUST00000239415.2 Transcriptional coactivator that specifically associates with POU2F3. This complex drives the development of tuft cells, a rare a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues. (from UniProt F8VPY8) A0A6I8MWX2 Colca2 ENSMUST00000239415.1 F8VPY8 Gm684 OCAT2_MOUSE Pou2af3 uc288uxa.1 Transcriptional coactivator that specifically associates with POU2F3. This complex drives the development of tuft cells, a rare a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues. Interacts with POU2F3 in a DNA-dependent manner; this interaction increases POU2F3 transactivation activity. Cytoplasm Nucleus Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=F8VPY8-1; Sequence=Displayed; Name=2; IsoId=F8VPY8-2; Sequence=VSP_061668; Expressed in tuft cells. In the N-terminus possesses a conserved OCA domain for bivalent binding to class II POU domain-containing transcription factors and to an octamer DNA motif (5'-ATGAAAT-3'). Belongs to the POU2AF family. molecular_function cytoplasm biological_process uc288uxa.1 
ENSMUST00000239419.2 Gm54771 ENSMUST00000239419.2 Gm54771 (from geneSymbol) ENSMUST00000239419.1 uc288uxe.1 uc288uxe.1 
ENSMUST00000239420.2 Thoc2l ENSMUST00000239420.2 THO complex subunit 2-like, transcript variant 2 (from RefSeq NR_164628.1) BC005561 E9Q5E2 E9Q5E2_MOUSE ENSMUST00000239420.1 NR_164628 Thoc2l uc288uxf.1 Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A. Nucleus Belongs to the THOC2 family. THO complex THO complex part of transcription export complex mRNA binding mRNA processing mRNA export from nucleus uc288uxf.1 
ENSMUST00000239424.2 Gp2 ENSMUST00000239424.2 Gp2 (from geneSymbol) A0A0R4J0B9 A0A0R4J0B9_MOUSE AK009661 ENSMUST00000239424.1 Gp2 uc288uxj.1 uc288uxj.1 
ENSMUST00000239425.2 Fndc1 ENSMUST00000239425.2 fibronectin type III domain containing 1, transcript variant 1 (from RefSeq NM_001403750.1) A0A6I8MWX0 A0A6I8MWX0_MOUSE ENSMUST00000239425.1 Fndc1 NM_001403750 uc288uxk.1 uc288uxk.1 
ENSMUST00000239431.2 Grn ENSMUST00000239431.2 granulin (from RefSeq NM_008175.5) ENSMUST00000239431.1 Grn NM_008175 Q544Y8 Q544Y8_MOUSE uc288uxq.1 Secreted Belongs to the granulin family. uc288uxq.1 
ENSMUST00000239436.2 Saraf ENSMUST00000239436.2 Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. (from UniProt A0A0R4J0D1) A0A0R4J0D1 A0A0R4J0D1_MOUSE AK077118 ENSMUST00000239436.1 Saraf uc288uxv.1 Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB. Membrane ; Single- pass type I membrane protein Belongs to the SARAF family. endoplasmic reticulum membrane integral component of membrane integral component of endoplasmic reticulum membrane regulation of store-operated calcium entry uc288uxv.1 
ENSMUST00000239441.2 Tbc1d25 ENSMUST00000239441.2 TBC1 domain family, member 25, transcript variant 1 (from RefSeq NM_172478.4) A0A6I8MX15 A0A6I8MX15_MOUSE ENSMUST00000239441.1 NM_172478 Oatl1 Tbc1d25 mCG_116413 uc288uya.1 uc288uya.1 
ENSMUST00000239442.2 Tead1 ENSMUST00000239442.2 Nucleus (from UniProt Q3USK5) ENSMUST00000239442.1 L13853 Q3USK5 Q3USK5_MOUSE Tead1 uc288uyb.1 Nucleus RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm regulation of transcription, DNA-templated hippo signaling positive regulation of transcription from RNA polymerase II promoter uc288uyb.1 
ENSMUST00000239444.3 Gm17315 ENSMUST00000239444.3 predicted gene, 17315 (from RefSeq NR_165822.1) ENSMUST00000239444.1 ENSMUST00000239444.2 NR_165822 uc288uyd.1 uc288uyd.2 uc288uyd.1 uc288uyd.2 
ENSMUST00000239449.2 Shisal1 ENSMUST00000239449.2 Shisal1 (from geneSymbol) 1810041L15Rik BC062953 ENSMUST00000239449.1 H7BX53 H7BX53_MOUSE Shisal1 uc288uyi.1 membrane integral component of membrane uc288uyi.1 
ENSMUST00000239456.2 Gm10033 ENSMUST00000239456.2 predicted gene 10033, transcript variant 3 (from RefSeq NM_001374599.1) A0A6I8MX06 A0A6I8MX06_MOUSE ENSMUST00000239456.1 Gm10033 NM_001374599 uc288uyp.1 uc288uyp.1 
ENSMUST00000239468.2 Ranbp10 ENSMUST00000239468.2 RAN binding protein 10 (from RefSeq NM_145824.5) ENSMUST00000239468.1 Kiaa1464 NM_145824 Q69ZJ1 Q6VN19 Q8C328 Q8R1E6 RBP10_MOUSE uc288uzb.1 May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (PubMed:18347012). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (PubMed:19801445). May form homodimers. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with RAN and RANBP9. Interacts with the HGF receptor MET. Interacts with AR (By similarity). Interacts with TUBB1 (PubMed:18347012). Interacts with YPEL5 (By similarity). May interact with TUBB5 (PubMed:18347012). Interacts with DDX4 (PubMed:27622290). Cytoplasm Nucleus Note=Predominantly cytoplasmic. Associates with cytoplasmic microtubules in mature megakaryocytes and platelets. Expressed at highest levels in spleen and liver. Expressed in megakaryocytes and platelets (at protein level). The SPRY domain mediates the interaction with MET. Mutant mice are viable and show no conspicuous phenotype. They have normal platelet counts and only slightly reduced proplatelet formation. Resting platelets tend to have a more spherical shape. Many platelets exhibit disorders in microtubule filament numbers and localization. The animals show a markedly prolonged bleeding time. Granule release is also reduced. Belongs to the RANBP9/10 family. Sequence=AAH24698.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=AAR01221.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; ubiquitin ligase complex microtubule cytoskeleton organization Ran guanyl-nucleotide exchange factor activity nucleus cytoplasm Ran GTPase binding beta-tubulin binding cytoplasmic microtubule uc288uzb.1 
ENSMUST00000239470.2 Acp7 ENSMUST00000239470.2 acid phosphatase 7, tartrate resistant (from RefSeq NM_175319.5) ACP7_MOUSE Acp7 ENSMUST00000239470.1 NM_175319 Papl Papl1 Q8BX37 uc288uzd.1 Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2; Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence=; Note=Binds 1 Fe cation per subunit. ; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit. ; Secreted Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. Sequence=AAH94908.1; Type=Erroneous initiation; Evidence=; Sequence=AAI32376.1; Type=Erroneous initiation; Evidence=; Sequence=BAC33559.1; Type=Erroneous initiation; Evidence=; acid phosphatase activity cellular_component extracellular region biological_process dephosphorylation hydrolase activity metal ion binding uc288uzd.1 
ENSMUST00000239472.2 Ube2srt ENSMUST00000239472.2 Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence=; (from UniProt A0A6I8MX03) A0A6I8MX03 A0A6I8MX03_MOUSE BC083323 ENSMUST00000239472.1 Gm2296 Ube2srt uc288uzf.1 Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence=; Belongs to the ubiquitin-conjugating enzyme family. uc288uzf.1 
ENSMUST00000239474.2 Golga2 ENSMUST00000239474.2 Golga2 (from geneSymbol) A0A6I8MX07 A0A6I8MX07_MOUSE AK220509 ENSMUST00000239474.1 Golga2 uc288uzh.1 uc288uzh.1 
ENSMUST00000239481.2 Gm56820 ENSMUST00000239481.2 Gm56820 (from geneSymbol) A0A6I8MWZ3 A0A6I8MWZ3_MOUSE AK015906 ENSMUST00000239481.1 Gm56820 uc288uzo.1 uc288uzo.1 
ENSMUST00000239483.2 Zdbf2 ENSMUST00000239483.2 zinc finger, DBF-type containing 2, transcript variant 4 (from RefSeq NM_001285937.1) A0A6I8MWW6 A0A6I8MWW6_MOUSE ENSMUST00000239483.1 NM_001285937 Zdbf2 uc288uzq.1 uc288uzq.1 
ENSMUST00000239500.1 Muc6 ENSMUST00000239500.1 mucin 6, gastric, transcript variant 1 (from RefSeq NM_001368953.3) A0A7N9VSS4 A0A7N9VSS4_MOUSE Muc6 NM_001368953 uc288vah.1 Lacks conserved residue(s) required for the propagation of feature annotation. uc288vah.1 
ENSMUST00000239501.2 Tctn2 ENSMUST00000239501.2 tectonic family member 2 (from RefSeq NM_026486.3) ENSMUST00000239501.1 NM_026486 Q2MV57 Q6PDZ5 Q8C0B3 Q9CXF5 TECT2_MOUSE Tect2 uc288vai.1 Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction. Part of the tectonic-like complex (also named B9 complex). Membrane ; Single-pass type I membrane protein Cytoplasm, cytoskeleton, cilium basal body Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2MV57-1; Sequence=Displayed; Name=2; IsoId=Q2MV57-2; Sequence=VSP_017766; Significant expression is observed in brain, kidney and eye. At 8.5 dpc, expressed in the neural tube, most notably in the rhombomere of the future hindbrain. By 10.5 dpc, expressed throughout the brain, the length of the neural tube, the growing edge of the limb buds, heart, and eyes. Strong expression is observed in the kidney at 14.5 dpc. Mice have ventricular septal defects and can display right-sided stomach. The embryos exhibit microphthalmia, cleft palate and polydactyly. Embryos lack also nodal cilia. Cilia in neural tubes are scarce and morphologically defective, and failed to elongate axonemes. Basal bodies dock to the plasma membrane in Tctn2 null neural epithelium. No Arl13b ciliary staining in defective Tctn2 embryos perineural mesenchyme suggesting that, as in Tctn1 null mutants, defective Tctn2 cilia lack Arl13b. Tctn1 and Tctn2 share a common function, with both affecting ciliogenesis in a tissue-specific manner. Belongs to the tectonic family. protein binding cytoplasm cytoskeleton smoothened signaling pathway membrane integral component of membrane cell projection organization MKS complex cell projection cilium assembly protein localization to ciliary transition zone uc288vai.1 
ENSMUST00000239506.1 Afg2b ENSMUST00000239506.1 AFG2 AAA ATPase homolog B, transcript variant 2 (from RefSeq NR_184860.1) A0A7N9VSG0 AFG2B_MOUSE NR_184860 Spata5l1 uc288van.1 ATP-dependent chaperone, which plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre- ribosomal particles. Acts together with AFG2A, AIRIM and CINP. Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.10; Evidence=; Associates with pre-60S ribosomal particles. Interacts with AIRIM. Cytoplasm Cytoplasm, cytoskeleton, spindle Nucleus In adult ear, expressed at low levels in neurosensory hair cells (inner and outer) and supporting cells (pillar and Deiter cells). Belongs to the AAA ATPase family. AFG2 subfamily. uc288van.1 
ENSMUST00000239509.1 Tusc3 ENSMUST00000239509.1 tumor suppressor candidate 3, transcript variant 4 (from RefSeq NM_001357306.1) A0A7N9VR83 A0A7N9VR83_MOUSE NM_001357306 Tusc3 uc288vaq.1 Protein modification; protein glycosylation. Endoplasmic reticulum membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein Belongs to the OST3/OST6 family. uc288vaq.1 
ENSMUST00000239512.1 Lin54 ENSMUST00000239512.1 lin-54 DREAM MuvB core complex component, transcript variant 2 (from RefSeq NM_172714.5) A0JLY2 Kiaa2037 LIN54_MOUSE NM_172714 Q3KQN0 Q3UYW5 Q571G4 Q8BMU8 Q8C107 uc288vat.1 Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, RBL2, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (By similarity). Nucleus Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q571G4-1; Sequence=Displayed; Name=2; IsoId=Q571G4-2; Sequence=VSP_034277; Name=3; IsoId=Q571G4-3; Sequence=VSP_034278, VSP_034279; The CRC domain mediates DNA-binding. It contains two CXC subdomains (joined by a flexible linker) which are both required for efficient association with target DNA. Each CXC subdomain coordinates three Zn(2+) ions. Belongs to the lin-54 family. Sequence=AAI06127.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=; Sequence=BAD90150.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; RNA polymerase II regulatory region sequence-specific DNA binding DNA binding nucleus regulation of transcription, DNA-templated cell cycle metal ion binding uc288vat.1 
ENSMUST00000239516.1 Efcab7 ENSMUST00000239516.1 Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:24582806). Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia (PubMed:24582806). (from UniProt Q8VDY4) AK142188 EFCB7_MOUSE Kiaa1799 Q3UQS0 Q5DTU8 Q8VDY4 uc288vax.1 Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:24582806). Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia (PubMed:24582806). Component of the EvC complex composed of EFCAB7, IQCE, EVC2 and EVC; built from two subcomplexes, EVC2:EVC and EFCAB7:IQCE (PubMed:24582806). Interacts (via EF-hand 1 and 2) with IQCE (via N- terminus); this interaction anchors the EVC-EVC2 complex in a signaling microdomain at the base of cilia and stimulates the Hedgehog (Hh) pathway (PubMed:24582806). Interacts with EVC2 (via N-terminal end) (PubMed:24582806). Interacts with EVC (PubMed:24582806). Cell projection, cilium membrane ; Peripheral membrane protein ; Cytoplasmic side Note=The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner (PubMed:24582806). Sequence=BAD90467.1; Type=Erroneous initiation; Evidence=; Sequence=BAE24969.1; Type=Erroneous initiation; Evidence=; calcium ion binding protein binding plasma membrane membrane extrinsic component of membrane positive regulation of protein import into nucleus cell projection positive regulation of transcription from RNA polymerase II promoter metal ion binding ciliary membrane plasma membrane protein complex positive regulation of protein localization to ciliary membrane uc288vax.1 
ENSMUST00000239525.1 Ahnak2 ENSMUST00000239525.1 AHNAK nucleoprotein 2, transcript variant 2 (from RefSeq NM_001378499.1) A0A7N9VR94 A0A7N9VR94_MOUSE Ahnak2 NM_001378499 uc288vbg.1 Nucleus uc288vbg.1 
ENSMUST00000239527.1 Rps6ka4 ENSMUST00000239527.1 ribosomal protein S6 kinase, polypeptide 4 (from RefSeq NM_019924.2) KS6A4_MOUSE Msk2 NM_019924 Q3U3M8 Q91X18 Q9Z2B9 uc288vbi.1 Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser- 28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Activated by phosphorylation at Ser-343, Thr-568 and Thr-687 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha, and by further autophosphorylation of Ser-196, Ser-360 and Ser-365 by the activated C-terminal kinase domain. Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA4 associates with and phosphorylates the NF-kappa-B p65 subunit RELA (By similarity). Q9Z2B9; P63085: Mapk1; NbExp=3; IntAct=EBI-412887, EBI-397697; Nucleus Ser-343 and Thr-568 phosphorylation is required for kinase activity. Ser-343 and Ser-196 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain. Phosphorylated at Ser-343, Thr-568 and Thr-687 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha. Autophosphorylated at Ser-737 and Ser-745 by the N-terminal kinase domain (By similarity). Enzyme activity requires the presence of both kinase domains. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated protein phosphorylation inflammatory response kinase activity phosphorylation transferase activity positive regulation of histone phosphorylation positive regulation of histone acetylation intracellular signal transduction histone H3-S10 phosphorylation histone H3-S28 phosphorylation positive regulation of transcription from RNA polymerase II promoter interleukin-1-mediated signaling pathway uc288vbi.1 
ENSMUST00000239533.1 Arvcf ENSMUST00000239533.1 armadillo repeat gene deleted in velocardiofacial syndrome, transcript variant 3 (from RefSeq NM_001272029.1) ARVC_MOUSE NM_001272029 P98203 Q6PGJ6 Q8BQ36 Q8BRF2 Q8C3U7 Q924L2 Q924L3 Q924L4 Q924L5 uc288vbo.1 Contributes to the regulation of alternative splicing of pre- mRNAs. Component of a ribonucleoprotein complex containing mRNAs and RNA-binding proteins including DDX5, HNRNPH2 and SRSF1 as well as ARVCF (By similarity). Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). Interacts with CCDC85B (By similarity). Cell junction, adherens junction Nucleus Cytoplasm Note=In heart, localizes at area composita, the mixed-type junctional structure composed of both desmosomal and adherens junctional proteins. Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=A1; IsoId=P98203-1; Sequence=Displayed; Name=2; Synonyms=A2; IsoId=P98203-2; Sequence=VSP_014923; Name=4; Synonyms=B2; IsoId=P98203-4; Sequence=VSP_014922, VSP_014923; Name=5; Synonyms=B1; IsoId=P98203-5; Sequence=VSP_014922; Belongs to the beta-catenin family. Sequence=AJ243418; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence=; protein binding nucleus cytoplasm plasma membrane cell-cell junction cell-cell adherens junction cell-cell junction assembly cell adhesion multicellular organism development calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cadherin binding cell-cell adhesion uc288vbo.1 
ENSMUST00000239539.1 Mir669a-7 ENSMUST00000239539.1 microRNA 669a-7 (from RefSeq NR_037255.1) NR_037255 uc288vbu.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vbu.1 
ENSMUST00000239545.1 Muc19 ENSMUST00000239545.1 mucin 19 (from RefSeq NM_207243.3) A7UN62 A7UN63 A7UN64 A7UN66 MUC19_MOUSE NM_207243 Q6P7U5 Q6PZE0 Q6Y0X6 Q80UR5 uc288vca.1 May function in ocular mucus homeostasis. Secreted Event=Alternative splicing; Named isoforms=6; Comment=Isoform 1 and isoform 2-6 share the first 17 amino acid residues that correspond to the signal sequence.; Name=1; Synonyms=Mucin-19; IsoId=Q6PZE0-1; Sequence=Displayed; Name=2; Synonyms=Smgc; IsoId=Q6JHY2-1; Sequence=External; Name=3; IsoId=Q6JHY2-2; Sequence=External; Name=4; IsoId=Q6JHY2-3; Sequence=External; Name=5; Synonyms=t-Smgc; IsoId=Q6JHY2-4; Sequence=External; Name=6; IsoId=Q6JHY2-5; Sequence=External; Specifically expressed in sublingual salivary glands. Expressed by mucous cells of the submandibular gland and submucosal gland of the trachea. Expression is altered in sld (sublingual gland differentiation arrest) mutants. Sequence=AAO49800.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence=; Name=Mucin database; URL="http://www.medkem.gu.se/mucinbiology/databases/"; hematopoietic progenitor cell differentiation molecular_function cellular_component extracellular region negative regulation of inflammatory response cell differentiation involved in salivary gland development uc288vca.1 
ENSMUST00000239546.1 Gm24897 ENSMUST00000239546.1 Gm24897 (from geneSymbol) uc288vcb.1 uc288vcb.1 
ENSMUST00000239552.1 Eppk1 ENSMUST00000239552.1 Cytoplasm, cytoskeleton (from UniProt A0A7N9VRC4) A0A7N9VRC4 A0A7N9VRC4_MOUSE AY312170 Eppk1 uc288vch.1 Cytoplasm, cytoskeleton Belongs to the plakin or cytolinker family. uc288vch.1 
ENSMUST00000239554.1 Muc4 ENSMUST00000239554.1 mucin 4 (from RefSeq NM_080457.5) A0A7N9VSW1 A0A7N9VSW1_MOUSE Muc4 NM_080457 uc288vcj.1 The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface. A large 5' exon encodes at least 15 tandem repeats of 124-126 amino acids. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. The RefSeq includes an unresolved tandem repeat and may not correctly represent the genomic sequence. Two deletions were introduced in the repeat region compared to the reference genome to maintain the reading frame compared to mouse and human protein data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Lacks conserved residue(s) required for the propagation of feature annotation. uc288vcj.1 
ENSMUST00000239562.1 Slc26a6 ENSMUST00000239562.1 solute carrier family 26, member 6, transcript variant 1 (from RefSeq NM_134420.5) Cfex E9Q4D3 NM_134420 Pat1 Q3TQD3 Q812E2 Q8CIW6 Q8CJD0 Q8K142 Q923J3 S26A6_MOUSE Slc26a6 uc288vcr.1 Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS- sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate- sulfate and chloride-formate exchange. Apical membrane chloride- bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH. [Isoform 2]: Mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2 (PubMed:12217875, PubMed:23933580). Also mediates exchange of chloride- formate and chloride-oxalate ions (PubMed:11459928, PubMed:12217875, PubMed:15203903, PubMed:17151144, PubMed:23933580). Mediates transcellular sulfate absorption (PubMed:12217875). Reaction=chloride(out) + 2 hydrogencarbonate(in) = chloride(in) + 2 hydrogencarbonate(out); Xref=Rhea:RHEA:72207, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996; Evidence= Reaction=chloride(out) + oxalate(in) = chloride(in) + oxalate(out); Xref=Rhea:RHEA:72263, ChEBI:CHEBI:17996, ChEBI:CHEBI:30623; Evidence= Reaction=formate(out) + oxalate(in) = formate(in) + oxalate(out); Xref=Rhea:RHEA:72271, ChEBI:CHEBI:15740, ChEBI:CHEBI:30623; Evidence=; Reaction=oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in); Xref=Rhea:RHEA:72275, ChEBI:CHEBI:16189, ChEBI:CHEBI:30623; Evidence=; [Isoform 2]: Reaction=chloride(out) + 2 hydrogencarbonate(in) = chloride(in) + 2 hydrogencarbonate(out); Xref=Rhea:RHEA:72207, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996; Evidence= [Isoform 2]: Reaction=chloride(out) + oxalate(in) = chloride(in) + oxalate(out); Xref=Rhea:RHEA:72263, ChEBI:CHEBI:17996, ChEBI:CHEBI:30623; Evidence= [Isoform 2]: Reaction=chloride(out) + formate(in) = chloride(in) + formate(out); Xref=Rhea:RHEA:72267, ChEBI:CHEBI:15740, ChEBI:CHEBI:17996; Evidence= [Isoform 2]: Reaction=sulfate(in) = sulfate(out); Xref=Rhea:RHEA:34983, ChEBI:CHEBI:16189; Evidence=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:34985; Evidence=; [Isoform 5]: Reaction=chloride(out) + 2 hydrogencarbonate(in) = chloride(in) + 2 hydrogencarbonate(out); Xref=Rhea:RHEA:72207, ChEBI:CHEBI:17544, ChEBI:CHEBI:17996; Evidence=; [Isoform 5]: Reaction=chloride(out) + oxalate(in) = chloride(in) + oxalate(out); Xref=Rhea:RHEA:72263, ChEBI:CHEBI:17996, ChEBI:CHEBI:30623; Evidence=; Apical membrane chloride-bicarbonate exchange activity of the pancreatic duct is inhibited by 4,4'- diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Oxalate secretion in the duodenum and chloride-formate exchange activity is inhibited by DIDS. [Isoform 2]: Chloride-formate exchange activity and transcellular sulfate absorption is inhibited by 4,4'- diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Kinetic parameters: KM=0.3 mM for oxalate ; [Isoform 2]: Kinetic parameters: KM=3.87 mM for formate ; Interacts (via C-terminal domain) with PDZK1 (via C-terminal PDZ domain); the interaction induces chloride and oxalate exchange transport (PubMed:16141316). Interacts with CFTR, SLC26A3 and NHERF1 (PubMed:21976599). Interacts with AHCYL1; the interaction increases SLC26A6 activity (PubMed:23542070). Q8CIW6; P26361: Cftr; NbExp=3; IntAct=EBI-6895517, EBI-6115317; Q8CIW6; P70441: Nherf1; NbExp=2; IntAct=EBI-6895517, EBI-1184085; Q8CIW6; Q9WVC8: Slc26a3; NbExp=2; IntAct=EBI-6895517, EBI-6895537; Cell membrane ; Multi-pass membrane protein Apical cell membrane ulti-pass membrane protein Cytoplasmic vesicle membrane ; Multi-pass membrane protein Microsome Note=Localized in sperm membranes. Colocalizes with CFTR at the midpiece of sperm tail. Localizes to the apical membrane brush border of epithelial cells in the proximal tubules of kidney, of enterocytes of the small intestine and of gastric parietal cells in the stomach. [Isoform 2]: Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein [Isoform 4]: Cell membrane ; Multi-pass membrane protein [Isoform 5]: Cell membrane ; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Slc26a6a ; IsoId=Q8CIW6-1; Sequence=Displayed; Name=2; Synonyms=Slc26a6b ; IsoId=Q8CIW6-2; Sequence=VSP_047853; Name=3; IsoId=Q8CIW6-3; Sequence=VSP_047853, VSP_047854; Name=4; Synonyms=Slc26a6c ; IsoId=Q8CIW6-4; Sequence=VSP_047853, VSP_061788; Name=5; Synonyms=Slc26a6d ; IsoId=Q8CIW6-5; Sequence=VSP_047853, VSP_061789; Expressed in kidney (at protein level). Expressed in spermatogenic cells. Expressed in intestine, kidney, testis, brain, muscle, heart, and stomach. Expressed in the submandibular and sublingual salivary glands. [Isoform 2]: Highly expressed in stomach, kidney, heart and small intestine, low in the lung, liver, testis, brain, skeletal muscle and colon. [Isoform 4]: Expressed in the heart. [Isoform 5]: Expressed in the heart. Up-regulated by dietary fructose intake (at protein level). N-glycosylated (PubMed:27681177). Glycosylation at Asn-174 positively regulates its chloride oxalate exchanger activity (By similarity). Mice show an important decrease in salt absorption in the intestine and failed to develop hypertension on a high-fructose diet. Show a reduction in pancreatic duct fluid and bicarbonate secretion. Show enhanced oxalate absorption in the intestine leading to hyperoxalemia and hyperoxaluria with high incidence of calcium-oxalate stones formation. Sequence=AC168054; Type=Erroneous gene model prediction; Evidence=; Sequence=CAAA01111125; Type=Erroneous gene model prediction; Evidence=; Sequence=CAAA01200220; Type=Erroneous gene model prediction; Evidence=; chloride channel activity protein binding endoplasmic reticulum plasma membrane integral component of plasma membrane ion transport anion transport chloride transport secondary active sulfate transmembrane transporter activity sulfate transport anion transmembrane transporter activity vesicle membrane bicarbonate transmembrane transporter activity chloride transmembrane transporter activity sulfate transmembrane transporter activity antiporter activity anion:anion antiporter activity formate transmembrane transporter activity efflux transmembrane transporter activity formate efflux transmembrane transporter activity bicarbonate transport formate transport mannitol transport membrane integral component of membrane basolateral plasma membrane apical plasma membrane oxalate transmembrane transporter activity oxalate transport PDZ domain binding transepithelial chloride transport cytoplasmic vesicle membrane cytoplasmic vesicle brush border membrane vesicle chloride channel complex angiotensin-activated signaling pathway epithelial fluid transport intracellular membrane-bounded organelle oxalic acid secretion sperm capacitation intestinal absorption regulation of intracellular pH intracellular pH elevation transmembrane transport protein kinase C signaling transepithelial transport cellular response to cAMP cellular response to fructose stimulus cellular response to interferon-gamma sperm midpiece anion transmembrane transport sulfate transmembrane transport chloride transmembrane transport positive regulation of dipeptide transmembrane transport uc288vcr.1 
ENSMUST00000239566.1 Gm23047 ENSMUST00000239566.1 Gm23047 (from geneSymbol) uc288vcv.1 uc288vcv.1 
ENSMUST00000239568.1 Mir344d-3 ENSMUST00000239568.1 microRNA 344d-3 (from RefSeq NR_037209.1) NR_037209 uc288vcw.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609659.1 [ECO:0000345] ##Evidence-Data-END## uc288vcw.1 
ENSMUST00000239569.1 Gm25354 ENSMUST00000239569.1 Gm25354 (from geneSymbol) uc288vcx.1 uc288vcx.1 
ENSMUST00000239570.1 Gm22583 ENSMUST00000239570.1 Gm22583 (from geneSymbol) uc288vcy.1 uc288vcy.1 
ENSMUST00000239571.1 Gm25229 ENSMUST00000239571.1 Gm25229 (from geneSymbol) uc288vcz.1 uc288vcz.1 
ENSMUST00000239572.1 Gm22851 ENSMUST00000239572.1 Gm22851 (from geneSymbol) uc288vda.1 uc288vda.1 
ENSMUST00000239577.1 Gm25702 ENSMUST00000239577.1 Gm25702 (from geneSymbol) uc288vdb.1 uc288vdb.1 
ENSMUST00000239579.1 Gm23096 ENSMUST00000239579.1 Gm23096 (from geneSymbol) uc288vdc.1 uc288vdc.1 
ENSMUST00000239581.1 Gm22868 ENSMUST00000239581.1 Gm22868 (from geneSymbol) uc288vdd.1 uc288vdd.1 
ENSMUST00000239584.1 Gm26272 ENSMUST00000239584.1 Gm26272 (from geneSymbol) uc288vde.1 uc288vde.1 
ENSMUST00000239586.1 Gm23560 ENSMUST00000239586.1 Gm23560 (from geneSymbol) uc288vdf.1 uc288vdf.1 
ENSMUST00000239592.1 Gm22798 ENSMUST00000239592.1 Gm22798 (from geneSymbol) DQ558729 uc288vdg.1 uc288vdg.1 
ENSMUST00000239594.1 Gm25314 ENSMUST00000239594.1 Gm25314 (from geneSymbol) uc288vdh.1 uc288vdh.1 
ENSMUST00000239596.1 n-R5s107 ENSMUST00000239596.1 n-R5s107 (from geneSymbol) AB349563 uc288vdi.1 uc288vdi.1 
ENSMUST00000239597.2 Gm54390 ENSMUST00000239597.2 Gm54390 (from geneSymbol) ENSMUST00000239597.1 uc288vdj.1 uc288vdj.1 
ENSMUST00000239598.1 n-R5s120 ENSMUST00000239598.1 n-R5s120 (from geneSymbol) DQ545504 uc288vdk.1 uc288vdk.1 
ENSMUST00000239600.1 Snord3b2 ENSMUST00000239600.1 small nucleolar RNA, C/D box 3B2 (from RefSeq NR_027863.1) NR_027863 uc288vdl.1 uc288vdl.1 
ENSMUST00000239603.1 Gm25155 ENSMUST00000239603.1 Gm25155 (from geneSymbol) uc288vdm.1 uc288vdm.1 
ENSMUST00000239604.1 Gm23287 ENSMUST00000239604.1 Gm23287 (from geneSymbol) DQ561416 uc288vdn.1 uc288vdn.1 
ENSMUST00000239605.1 Gm24957 ENSMUST00000239605.1 Gm24957 (from geneSymbol) uc288vdo.1 uc288vdo.1 
ENSMUST00000239608.1 Gm24949 ENSMUST00000239608.1 Gm24949 (from geneSymbol) uc288vdp.1 uc288vdp.1 
ENSMUST00000239609.1 Gm23402 ENSMUST00000239609.1 Gm23402 (from geneSymbol) DQ558729 uc288vdq.1 uc288vdq.1 
ENSMUST00000239610.1 Snord116l13 ENSMUST00000239610.1 Snord116l13 (from geneSymbol) uc288vdr.1 uc288vdr.1 
ENSMUST00000239611.1 Gm24618 ENSMUST00000239611.1 Gm24618 (from geneSymbol) uc288vds.1 uc288vds.1 
ENSMUST00000239613.1 Gm26396 ENSMUST00000239613.1 Gm26396 (from geneSymbol) uc288vdt.1 uc288vdt.1 
ENSMUST00000239614.1 Gm25380 ENSMUST00000239614.1 Gm25380 (from geneSymbol) uc288vdu.1 uc288vdu.1 
ENSMUST00000239617.1 Gm22348 ENSMUST00000239617.1 Gm22348 (from geneSymbol) uc288vdv.1 uc288vdv.1 
ENSMUST00000239619.1 Gm25870 ENSMUST00000239619.1 Gm25870 (from geneSymbol) uc288vdw.1 uc288vdw.1 
ENSMUST00000239620.1 Gm22306 ENSMUST00000239620.1 Gm22306 (from geneSymbol) DQ558729 uc288vdx.1 uc288vdx.1 
ENSMUST00000239629.1 Gm24464 ENSMUST00000239629.1 Gm24464 (from geneSymbol) uc288vdy.1 uc288vdy.1 
ENSMUST00000239631.1 Gm22057 ENSMUST00000239631.1 Gm22057 (from geneSymbol) DQ558729 uc288vdz.1 uc288vdz.1 
ENSMUST00000239632.1 Gm24304 ENSMUST00000239632.1 Gm24304 (from geneSymbol) uc288vea.1 uc288vea.1 
ENSMUST00000239633.1 Gm22776 ENSMUST00000239633.1 Gm22776 (from geneSymbol) uc288veb.1 uc288veb.1 
ENSMUST00000239635.1 Gm22047 ENSMUST00000239635.1 Gm22047 (from geneSymbol) uc288vec.1 uc288vec.1 
ENSMUST00000239640.1 Gm23144 ENSMUST00000239640.1 Gm23144 (from geneSymbol) uc288ved.1 uc288ved.1 
ENSMUST00000239643.1 Gm26374 ENSMUST00000239643.1 Gm26374 (from geneSymbol) uc288vee.1 uc288vee.1 
ENSMUST00000239644.1 Gm26246 ENSMUST00000239644.1 Gm26246 (from geneSymbol) uc288vef.1 uc288vef.1 
ENSMUST00000239649.1 Mir669j ENSMUST00000239649.1 microRNA 669j (from RefSeq NR_035416.1) NR_035416 uc288veg.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288veg.1 
ENSMUST00000239650.1 Snord3b4 ENSMUST00000239650.1 Snord3b4 (from geneSymbol) AK019039 uc288veh.1 uc288veh.1 
ENSMUST00000239651.1 Gm23247 ENSMUST00000239651.1 Gm23247 (from geneSymbol) uc288vei.1 uc288vei.1 
ENSMUST00000239654.1 Gm25023 ENSMUST00000239654.1 Gm25023 (from geneSymbol) uc288vej.1 uc288vej.1 
ENSMUST00000239657.1 Gm25328 ENSMUST00000239657.1 Gm25328 (from geneSymbol) uc288vek.1 uc288vek.1 
ENSMUST00000239658.1 Gm22263 ENSMUST00000239658.1 Gm22263 (from geneSymbol) uc288vel.1 uc288vel.1 
ENSMUST00000239660.1 n-R5s123 ENSMUST00000239660.1 nuclear encoded rRNA 5S 123 (from RefSeq NR_046132.1) NR_046132 uc288vem.1 uc288vem.1 
ENSMUST00000239661.1 Gm25484 ENSMUST00000239661.1 Gm25484 (from geneSymbol) DQ558729 uc288ven.1 uc288ven.1 
ENSMUST00000239663.1 Gm24868 ENSMUST00000239663.1 Gm24868 (from geneSymbol) uc288veo.1 uc288veo.1 
ENSMUST00000239664.1 Gm25471 ENSMUST00000239664.1 Gm25471 (from geneSymbol) uc288vep.1 uc288vep.1 
ENSMUST00000239666.1 Mir344d-2 ENSMUST00000239666.1 microRNA 344d-2 (from RefSeq NR_037216.1) NR_037216 uc288veq.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM609676.1 [ECO:0000345] ##Evidence-Data-END## uc288veq.1 
ENSMUST00000239668.1 n-R5s106 ENSMUST00000239668.1 n-R5s106 (from geneSymbol) AB349563 uc288ver.1 uc288ver.1 
ENSMUST00000239669.1 Gm23137 ENSMUST00000239669.1 Gm23137 (from geneSymbol) DQ558729 uc288ves.1 uc288ves.1 
ENSMUST00000239673.1 Gm25741 ENSMUST00000239673.1 Gm25741 (from geneSymbol) uc288vet.1 uc288vet.1 
ENSMUST00000239674.1 Gm24518 ENSMUST00000239674.1 Gm24518 (from geneSymbol) uc288veu.1 uc288veu.1 
ENSMUST00000239676.1 Gm24389 ENSMUST00000239676.1 Gm24389 (from geneSymbol) DQ558729 uc288vev.1 uc288vev.1 
ENSMUST00000239679.1 Gm24986 ENSMUST00000239679.1 Gm24986 (from geneSymbol) uc288vew.1 uc288vew.1 
ENSMUST00000239680.1 Gm24265 ENSMUST00000239680.1 Gm24265 (from geneSymbol) M18004 uc288vex.1 uc288vex.1 
ENSMUST00000239681.1 Gm22823 ENSMUST00000239681.1 Gm22823 (from geneSymbol) DQ558729 uc288vey.1 uc288vey.1 
ENSMUST00000239682.1 Gm25829 ENSMUST00000239682.1 Gm25829 (from geneSymbol) DQ558729 uc288vez.1 uc288vez.1 
ENSMUST00000239683.1 n-R5s130 ENSMUST00000239683.1 n-R5s130 (from geneSymbol) AB349296 uc288vfa.1 uc288vfa.1 
ENSMUST00000239684.1 Gm25121 ENSMUST00000239684.1 Gm25121 (from geneSymbol) uc288vfb.1 uc288vfb.1 
ENSMUST00000239685.1 Gm26365 ENSMUST00000239685.1 Gm26365 (from geneSymbol) uc288vfc.1 uc288vfc.1 
ENSMUST00000239686.1 Gm22638 ENSMUST00000239686.1 Gm22638 (from geneSymbol) uc288vfd.1 uc288vfd.1 
ENSMUST00000239687.1 Snord3b3 ENSMUST00000239687.1 small nucleolar RNA, C/D box 3B3 (from RefSeq NR_004416.1) NR_004416 uc288vfe.1 uc288vfe.1 
ENSMUST00000239688.1 Gm24655 ENSMUST00000239688.1 Gm24655 (from geneSymbol) uc288vff.1 uc288vff.1 
ENSMUST00000239689.1 Gm22269 ENSMUST00000239689.1 Gm22269 (from geneSymbol) uc288vfg.1 uc288vfg.1 
ENSMUST00000239693.1 Gm24609 ENSMUST00000239693.1 Gm24609 (from geneSymbol) uc288vfh.1 uc288vfh.1 
ENSMUST00000239694.1 Gm22628 ENSMUST00000239694.1 Gm22628 (from geneSymbol) DQ558729 uc288vfi.1 uc288vfi.1 
ENSMUST00000239695.1 Gm22169 ENSMUST00000239695.1 Gm22169 (from geneSymbol) uc288vfj.1 uc288vfj.1 
ENSMUST00000239696.1 Gm22128 ENSMUST00000239696.1 Gm22128 (from geneSymbol) uc288vfk.1 uc288vfk.1 
ENSMUST00000239697.1 Gm25646 ENSMUST00000239697.1 Gm25646 (from geneSymbol) uc288vfl.1 uc288vfl.1 
ENSMUST00000239699.1 Gm26427 ENSMUST00000239699.1 Gm26427 (from geneSymbol) DQ558729 uc288vfm.1 uc288vfm.1 
ENSMUST00000239700.1 Gm25596 ENSMUST00000239700.1 Gm25596 (from geneSymbol) uc288vfn.1 uc288vfn.1 
ENSMUST00000239703.1 Gm22969 ENSMUST00000239703.1 Gm22969 (from geneSymbol) DQ558729 uc288vfo.1 uc288vfo.1 
ENSMUST00000239704.1 Gm26243 ENSMUST00000239704.1 Gm26243 (from geneSymbol) DQ558729 uc288vfp.1 uc288vfp.1 
ENSMUST00000239705.1 Gm24797 ENSMUST00000239705.1 Gm24797 (from geneSymbol) uc288vfq.1 uc288vfq.1 
ENSMUST00000239706.1 Mir692-2 ENSMUST00000239706.1 microRNA 692-2 (from RefSeq NR_109835.1) NR_109835 uc288vfr.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: SRR1660815.2183.1, SRR1660813.113869.1 [ECO:0000345] ##Evidence-Data-END## uc288vfr.1 
ENSMUST00000239707.1 Gm24099 ENSMUST00000239707.1 Gm24099 (from geneSymbol) uc288vfs.1 uc288vfs.1 
ENSMUST00000239709.1 Gm22510 ENSMUST00000239709.1 Gm22510 (from geneSymbol) uc288vft.1 uc288vft.1 
ENSMUST00000239711.1 Gm26177 ENSMUST00000239711.1 Gm26177 (from geneSymbol) uc288vfu.1 uc288vfu.1 
ENSMUST00000239713.1 Gm25598 ENSMUST00000239713.1 Gm25598 (from geneSymbol) uc288vfv.1 uc288vfv.1 
ENSMUST00000239716.1 n-R5s197 ENSMUST00000239716.1 n-R5s197 (from geneSymbol) LF193991 uc288vfw.1 uc288vfw.1 
ENSMUST00000239717.1 Gm25256 ENSMUST00000239717.1 Gm25256 (from geneSymbol) DQ558729 uc288vfx.1 uc288vfx.1 
ENSMUST00000239718.1 Gm25987 ENSMUST00000239718.1 Gm25987 (from geneSymbol) uc288vfy.1 uc288vfy.1 
ENSMUST00000239719.1 Gm25798 ENSMUST00000239719.1 Gm25798 (from geneSymbol) uc288vfz.1 uc288vfz.1 
ENSMUST00000239720.1 Snord116l6 ENSMUST00000239720.1 Snord116l6 (from geneSymbol) uc288vga.1 uc288vga.1 
ENSMUST00000239721.1 Gm24711 ENSMUST00000239721.1 Gm24711 (from geneSymbol) uc288vgb.1 uc288vgb.1 
ENSMUST00000239725.1 Gm24350 ENSMUST00000239725.1 Gm24350 (from geneSymbol) uc288vgc.1 uc288vgc.1 
ENSMUST00000239726.1 Gm24674 ENSMUST00000239726.1 Gm24674 (from geneSymbol) uc288vgd.1 uc288vgd.1 
ENSMUST00000239727.1 Gm22822 ENSMUST00000239727.1 Gm22822 (from geneSymbol) LF196528 uc288vge.1 uc288vge.1 
ENSMUST00000239728.1 Gm24487 ENSMUST00000239728.1 Gm24487 (from geneSymbol) uc288vgf.1 uc288vgf.1 
ENSMUST00000239730.1 Gm23356 ENSMUST00000239730.1 Gm23356 (from geneSymbol) AF357427 uc288vgg.1 uc288vgg.1 
ENSMUST00000239733.1 Gm25020 ENSMUST00000239733.1 Gm25020 (from geneSymbol) uc288vgh.1 uc288vgh.1 
ENSMUST00000239734.1 Mir466b-6 ENSMUST00000239734.1 microRNA 466b-6 (from RefSeq NR_130338.1) NR_130338 uc288vgi.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vgi.1 
ENSMUST00000239735.1 Gm25090 ENSMUST00000239735.1 Gm25090 (from geneSymbol) uc288vgj.1 uc288vgj.1 
ENSMUST00000239737.1 Gm26502 ENSMUST00000239737.1 Gm26502 (from geneSymbol) uc288vgk.1 uc288vgk.1 
ENSMUST00000239738.1 Gm26435 ENSMUST00000239738.1 Gm26435 (from geneSymbol) uc288vgl.1 uc288vgl.1 
ENSMUST00000239739.1 Gm22360 ENSMUST00000239739.1 Gm22360 (from geneSymbol) DQ558729 uc288vgm.1 uc288vgm.1 
ENSMUST00000239740.2 Gm22155 ENSMUST00000239740.2 Gm22155 (from geneSymbol) ENSMUST00000239740.1 uc288vgn.1 uc288vgn.1 
ENSMUST00000239741.1 Gm23934 ENSMUST00000239741.1 Gm23934 (from geneSymbol) DQ558729 uc288vgo.1 uc288vgo.1 
ENSMUST00000239744.1 Gm23313 ENSMUST00000239744.1 Gm23313 (from geneSymbol) uc288vgp.1 uc288vgp.1 
ENSMUST00000239745.1 Gm22352 ENSMUST00000239745.1 Gm22352 (from geneSymbol) DQ558729 uc288vgq.1 uc288vgq.1 
ENSMUST00000239746.1 Gm24654 ENSMUST00000239746.1 Gm24654 (from geneSymbol) uc288vgr.1 uc288vgr.1 
ENSMUST00000239747.2 Gm23242 ENSMUST00000239747.2 Gm23242 (from geneSymbol) ENSMUST00000239747.1 uc288vgs.1 uc288vgs.1 
ENSMUST00000239748.1 n-R5s139 ENSMUST00000239748.1 nuclear encoded rRNA 5S 139 (from RefSeq NR_046146.1) NR_046146 uc288vgt.1 uc288vgt.1 
ENSMUST00000239749.1 Gm22129 ENSMUST00000239749.1 Gm22129 (from geneSymbol) DQ558729 uc288vgu.1 uc288vgu.1 
ENSMUST00000239750.1 Gm24753 ENSMUST00000239750.1 Gm24753 (from geneSymbol) DQ558729 uc288vgv.1 uc288vgv.1 
ENSMUST00000239757.1 Gm22629 ENSMUST00000239757.1 Gm22629 (from geneSymbol) uc288vgw.1 uc288vgw.1 
ENSMUST00000239762.1 Gm26391 ENSMUST00000239762.1 predicted gene, 26391 (from RefSeq NR_046140.1) NR_046140 uc288vgx.1 uc288vgx.1 
ENSMUST00000239763.1 Gm25462 ENSMUST00000239763.1 Gm25462 (from geneSymbol) uc288vgy.1 uc288vgy.1 
ENSMUST00000239765.1 Gm26189 ENSMUST00000239765.1 Gm26189 (from geneSymbol) DQ558729 uc288vgz.1 uc288vgz.1 
ENSMUST00000239767.1 Gm23732 ENSMUST00000239767.1 Gm23732 (from geneSymbol) DQ558729 uc288vha.1 uc288vha.1 
ENSMUST00000239771.1 n-R5s133 ENSMUST00000239771.1 nuclear encoded rRNA 5S 133 (from RefSeq NR_046141.1) NR_046141 uc288vhb.1 uc288vhb.1 
ENSMUST00000239774.1 Gm23688 ENSMUST00000239774.1 Gm23688 (from geneSymbol) uc288vhc.1 uc288vhc.1 
ENSMUST00000239775.1 Gm25890 ENSMUST00000239775.1 Gm25890 (from geneSymbol) AB349931 uc288vhd.1 uc288vhd.1 
ENSMUST00000239776.1 Gm29163 ENSMUST00000239776.1 Gm29163 (from geneSymbol) DQ558729 uc288vhe.1 uc288vhe.1 
ENSMUST00000239778.1 n-R5s124 ENSMUST00000239778.1 nuclear encoded rRNA 5S 124 (from RefSeq NR_046133.1) NR_046133 uc288vhf.1 uc288vhf.1 
ENSMUST00000239779.1 Gm25755 ENSMUST00000239779.1 Gm25755 (from geneSymbol) uc288vhg.1 uc288vhg.1 
ENSMUST00000239780.1 Gm22287 ENSMUST00000239780.1 Gm22287 (from geneSymbol) uc288vhh.1 uc288vhh.1 
ENSMUST00000239781.1 Gm26466 ENSMUST00000239781.1 Gm26466 (from geneSymbol) uc288vhi.1 uc288vhi.1 
ENSMUST00000239783.1 Gm26032 ENSMUST00000239783.1 Gm26032 (from geneSymbol) uc288vhj.1 uc288vhj.1 
ENSMUST00000239784.1 Gm23148 ENSMUST00000239784.1 Gm23148 (from geneSymbol) DQ558729 uc288vhk.1 uc288vhk.1 
ENSMUST00000239785.1 Gm26284 ENSMUST00000239785.1 Gm26284 (from geneSymbol) uc288vhl.1 uc288vhl.1 
ENSMUST00000239787.1 Gm26002 ENSMUST00000239787.1 Gm26002 (from geneSymbol) uc288vhm.1 uc288vhm.1 
ENSMUST00000239788.1 Gm25156 ENSMUST00000239788.1 Gm25156 (from geneSymbol) uc288vhn.1 uc288vhn.1 
ENSMUST00000239793.1 Gm24585 ENSMUST00000239793.1 Gm24585 (from geneSymbol) uc288vho.1 uc288vho.1 
ENSMUST00000239794.1 Gm25461 ENSMUST00000239794.1 Gm25461 (from geneSymbol) uc288vhp.1 uc288vhp.1 
ENSMUST00000239797.1 Gm22627 ENSMUST00000239797.1 Gm22627 (from geneSymbol) uc288vhq.1 uc288vhq.1 
ENSMUST00000239799.1 Gm25672 ENSMUST00000239799.1 Gm25672 (from geneSymbol) DQ558729 uc288vhr.1 uc288vhr.1 
ENSMUST00000239800.1 Gm25984 ENSMUST00000239800.1 Gm25984 (from geneSymbol) uc288vhs.1 uc288vhs.1 
ENSMUST00000239801.1 Gm22474 ENSMUST00000239801.1 Gm22474 (from geneSymbol) DQ558729 uc288vht.1 uc288vht.1 
ENSMUST00000239802.1 Gm25528 ENSMUST00000239802.1 Gm25528 (from geneSymbol) uc288vhu.1 uc288vhu.1 
ENSMUST00000239803.1 Mir297-1 ENSMUST00000239803.1 microRNA 297-1 (from RefSeq NR_029647.1) NR_029647 uc288vhv.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vhv.1 
ENSMUST00000239804.1 Gm25615 ENSMUST00000239804.1 Gm25615 (from geneSymbol) uc288vhw.1 uc288vhw.1 
ENSMUST00000239806.1 Gm24267 ENSMUST00000239806.1 Gm24267 (from geneSymbol) DQ558729 uc288vhx.1 uc288vhx.1 
ENSMUST00000239807.1 n-R5s121 ENSMUST00000239807.1 nuclear encoded rRNA 5S 121 (from RefSeq NR_046129.1) NR_046129 uc288vhy.1 uc288vhy.1 
ENSMUST00000239808.1 Gm25937 ENSMUST00000239808.1 Gm25937 (from geneSymbol) uc288vhz.1 uc288vhz.1 
ENSMUST00000239809.1 Gm23944 ENSMUST00000239809.1 Gm23944 (from geneSymbol) uc288via.1 uc288via.1 
ENSMUST00000239810.1 n-R5s131 ENSMUST00000239810.1 n-R5s131 (from geneSymbol) uc288vib.1 uc288vib.1 
ENSMUST00000239811.1 Gm23627 ENSMUST00000239811.1 Gm23627 (from geneSymbol) DQ558729 uc288vic.1 uc288vic.1 
ENSMUST00000239812.1 Gm25024 ENSMUST00000239812.1 Gm25024 (from geneSymbol) uc288vid.1 uc288vid.1 
ENSMUST00000239816.1 Mir466c-2 ENSMUST00000239816.1 microRNA 466c-2 (from RefSeq NR_130335.1) NR_130335 uc288vie.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vie.1 
ENSMUST00000239818.1 Gm24872 ENSMUST00000239818.1 Gm24872 (from geneSymbol) AF357427 uc288vif.1 uc288vif.1 
ENSMUST00000239819.1 Gm22264 ENSMUST00000239819.1 Gm22264 (from geneSymbol) uc288vig.1 uc288vig.1 
ENSMUST00000239820.1 Mir7684 ENSMUST00000239820.1 microRNA 7684 (from RefSeq NR_106153.1) NR_106153 uc288vih.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vih.1 
ENSMUST00000239821.1 Gm23731 ENSMUST00000239821.1 Gm23731 (from geneSymbol) uc288vii.1 uc288vii.1 
ENSMUST00000239822.1 Mir467a-9 ENSMUST00000239822.1 microRNA 467a-9 (from RefSeq NR_037265.1) NR_037265 uc288vij.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vij.1 
ENSMUST00000239823.1 Mir669a-6 ENSMUST00000239823.1 microRNA 669a-6 (from RefSeq NR_037253.1) NR_037253 uc288vik.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vik.1 
ENSMUST00000239826.1 Gm26496 ENSMUST00000239826.1 Gm26496 (from geneSymbol) DQ558729 uc288vil.1 uc288vil.1 
ENSMUST00000239827.1 Gm24830 ENSMUST00000239827.1 Gm24830 (from geneSymbol) DQ548138 uc288vim.1 uc288vim.1 
ENSMUST00000239830.1 Gm24565 ENSMUST00000239830.1 Gm24565 (from geneSymbol) DQ558729 uc288vin.1 uc288vin.1 
ENSMUST00000239831.1 Gm24568 ENSMUST00000239831.1 Gm24568 (from geneSymbol) uc288vio.1 uc288vio.1 
ENSMUST00000239832.1 Rn5s ENSMUST00000239832.1 5S RNA (from RefSeq NR_030686.1) NR_030686 uc288vip.1 uc288vip.1 
ENSMUST00000239833.1 Gm24528 ENSMUST00000239833.1 Gm24528 (from geneSymbol) AF357427 uc288viq.1 uc288viq.1 
ENSMUST00000239834.2 Gm25819 ENSMUST00000239834.2 Gm25819 (from geneSymbol) ENSMUST00000239834.1 uc288vir.1 uc288vir.1 
ENSMUST00000239835.1 Gm22308 ENSMUST00000239835.1 Gm22308 (from geneSymbol) DQ558729 uc288vis.1 uc288vis.1 
ENSMUST00000239836.1 Gm22290 ENSMUST00000239836.1 Gm22290 (from geneSymbol) uc288vit.1 uc288vit.1 
ENSMUST00000239837.1 Gm22633 ENSMUST00000239837.1 Gm22633 (from geneSymbol) uc288viu.1 uc288viu.1 
ENSMUST00000239838.1 Gm23573 ENSMUST00000239838.1 Gm23573 (from geneSymbol) uc288viv.1 uc288viv.1 
ENSMUST00000239839.1 Gm24205 ENSMUST00000239839.1 Gm24205 (from geneSymbol) DQ558729 uc288viw.1 uc288viw.1 
ENSMUST00000239840.1 Gm26332 ENSMUST00000239840.1 Gm26332 (from geneSymbol) uc288vix.1 uc288vix.1 
ENSMUST00000239841.1 Gm24873 ENSMUST00000239841.1 Gm24873 (from geneSymbol) DQ558729 uc288viy.1 uc288viy.1 
ENSMUST00000239843.2 Gm24384 ENSMUST00000239843.2 Gm24384 (from geneSymbol) ENSMUST00000239843.1 uc288viz.1 uc288viz.1 
ENSMUST00000239844.1 Gm24925 ENSMUST00000239844.1 Gm24925 (from geneSymbol) uc288vja.1 uc288vja.1 
ENSMUST00000239845.1 Gm25157 ENSMUST00000239845.1 Gm25157 (from geneSymbol) uc288vjb.1 uc288vjb.1 
ENSMUST00000239847.1 Gm22285 ENSMUST00000239847.1 Gm22285 (from geneSymbol) uc288vjc.1 uc288vjc.1 
ENSMUST00000239848.1 Gm26454 ENSMUST00000239848.1 Gm26454 (from geneSymbol) DQ558729 uc288vjd.1 uc288vjd.1 
ENSMUST00000239849.1 Gm25737 ENSMUST00000239849.1 Gm25737 (from geneSymbol) DQ558729 uc288vje.1 uc288vje.1 
ENSMUST00000239851.1 Gm25449 ENSMUST00000239851.1 Gm25449 (from geneSymbol) uc288vjf.1 uc288vjf.1 
ENSMUST00000239852.1 Gm25463 ENSMUST00000239852.1 Gm25463 (from geneSymbol) AF357427 uc288vjg.1 uc288vjg.1 
ENSMUST00000239853.1 n-R5s142 ENSMUST00000239853.1 nuclear encoded rRNA 5S 142 (from RefSeq NR_046149.1) NR_046149 uc288vjh.1 uc288vjh.1 
ENSMUST00000239855.1 Gm26331 ENSMUST00000239855.1 Gm26331 (from geneSymbol) DQ558729 uc288vji.1 uc288vji.1 
ENSMUST00000239857.1 Gm25258 ENSMUST00000239857.1 Gm25258 (from geneSymbol) DQ558729 uc288vjj.1 uc288vjj.1 
ENSMUST00000239858.1 Gm23092 ENSMUST00000239858.1 Gm23092 (from geneSymbol) DQ558729 uc288vjk.1 uc288vjk.1 
ENSMUST00000239859.1 Mir669a-4 ENSMUST00000239859.1 microRNA 669a-4 (from RefSeq NR_037250.1) NR_037250 uc288vjl.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vjl.1 
ENSMUST00000239860.1 Gm25988 ENSMUST00000239860.1 Gm25988 (from geneSymbol) uc288vjm.1 uc288vjm.1 
ENSMUST00000239862.1 Gm22524 ENSMUST00000239862.1 Gm22524 (from geneSymbol) uc288vjn.1 uc288vjn.1 
ENSMUST00000239864.1 Gm25017 ENSMUST00000239864.1 Gm25017 (from geneSymbol) uc288vjo.1 uc288vjo.1 
ENSMUST00000239868.1 Snord116l4 ENSMUST00000239868.1 Snord116l4 (from geneSymbol) uc288vjp.1 uc288vjp.1 
ENSMUST00000239869.1 Mir669a-10 ENSMUST00000239869.1 microRNA 669a-10 (from RefSeq NR_037264.1) NR_037264 uc288vjq.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vjq.1 
ENSMUST00000239870.1 Gm25120 ENSMUST00000239870.1 Gm25120 (from geneSymbol) uc288vjr.1 uc288vjr.1 
ENSMUST00000239871.2 Gm57326 ENSMUST00000239871.2 Gm57326 (from geneSymbol) ENSMUST00000239871.1 uc288vjs.1 uc288vjs.1 
ENSMUST00000239873.1 Gm22253 ENSMUST00000239873.1 Gm22253 (from geneSymbol) uc288vjt.1 uc288vjt.1 
ENSMUST00000239876.1 Gm23128 ENSMUST00000239876.1 Gm23128 (from geneSymbol) uc288vju.1 uc288vju.1 
ENSMUST00000239880.1 Gm23284 ENSMUST00000239880.1 predicted gene, 23284 (from RefSeq NR_046155.1) NR_046155 uc288vjv.1 uc288vjv.1 
ENSMUST00000239881.1 Gm25207 ENSMUST00000239881.1 Gm25207 (from geneSymbol) uc288vjw.1 uc288vjw.1 
ENSMUST00000239883.1 Gm22618 ENSMUST00000239883.1 Gm22618 (from geneSymbol) DQ558729 uc288vjx.1 uc288vjx.1 
ENSMUST00000239884.1 Gm25891 ENSMUST00000239884.1 Gm25891 (from geneSymbol) uc288vjy.1 uc288vjy.1 
ENSMUST00000239886.1 Gm24727 ENSMUST00000239886.1 Gm24727 (from geneSymbol) uc288vjz.1 uc288vjz.1 
ENSMUST00000239887.1 Gm23933 ENSMUST00000239887.1 Gm23933 (from geneSymbol) uc288vka.1 uc288vka.1 
ENSMUST00000239888.1 Gm23604 ENSMUST00000239888.1 Gm23604 (from geneSymbol) uc288vkb.1 uc288vkb.1 
ENSMUST00000239889.1 Mir467g ENSMUST00000239889.1 microRNA 467g (from RefSeq NR_130328.1) NR_130328 uc288vkc.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vkc.1 
ENSMUST00000239890.1 n-R5s211 ENSMUST00000239890.1 n-R5s211 (from geneSymbol) uc288vkd.1 uc288vkd.1 
ENSMUST00000239891.1 Gm23712 ENSMUST00000239891.1 Gm23712 (from geneSymbol) DQ558729 uc288vke.1 uc288vke.1 
ENSMUST00000239893.1 Mir467a-5 ENSMUST00000239893.1 microRNA 467a-5 (from RefSeq NR_037256.1) NR_037256 uc288vkf.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vkf.1 
ENSMUST00000239895.1 Gm25210 ENSMUST00000239895.1 Gm25210 (from geneSymbol) uc288vkg.1 uc288vkg.1 
ENSMUST00000239896.1 Gm25840 ENSMUST00000239896.1 Gm25840 (from geneSymbol) uc288vkh.1 uc288vkh.1 
ENSMUST00000239897.1 n-R5s64 ENSMUST00000239897.1 n-R5s64 (from geneSymbol) AB352282 uc288vki.1 uc288vki.1 
ENSMUST00000239898.1 Gm24653 ENSMUST00000239898.1 Gm24653 (from geneSymbol) uc288vkj.1 uc288vkj.1 
ENSMUST00000239899.1 n-R5s143 ENSMUST00000239899.1 nuclear encoded rRNA 5S 143 (from RefSeq NR_046150.1) NR_046150 uc288vkk.1 uc288vkk.1 
ENSMUST00000239900.1 Gm22997 ENSMUST00000239900.1 Gm22997 (from geneSymbol) DQ558729 uc288vkl.1 uc288vkl.1 
ENSMUST00000239901.1 Gm25873 ENSMUST00000239901.1 Gm25873 (from geneSymbol) DQ558729 uc288vkm.1 uc288vkm.1 
ENSMUST00000239902.1 Gm26239 ENSMUST00000239902.1 Gm26239 (from geneSymbol) DQ558729 uc288vkn.1 uc288vkn.1 
ENSMUST00000239904.1 Gm24153 ENSMUST00000239904.1 Gm24153 (from geneSymbol) uc288vko.1 uc288vko.1 
ENSMUST00000239906.1 Gm25797 ENSMUST00000239906.1 Gm25797 (from geneSymbol) uc288vkp.1 uc288vkp.1 
ENSMUST00000239909.1 Gm24219 ENSMUST00000239909.1 Gm24219 (from geneSymbol) uc288vkq.1 uc288vkq.1 
ENSMUST00000239911.1 Gm25327 ENSMUST00000239911.1 Gm25327 (from geneSymbol) DQ558729 uc288vkr.1 uc288vkr.1 
ENSMUST00000239914.1 n-R5s114 ENSMUST00000239914.1 n-R5s114 (from geneSymbol) uc288vks.1 uc288vks.1 
ENSMUST00000239915.1 Gm22046 ENSMUST00000239915.1 Gm22046 (from geneSymbol) uc288vkt.1 uc288vkt.1 
ENSMUST00000239917.1 n-R5s194 ENSMUST00000239917.1 n-R5s194 (from geneSymbol) AB349563 uc288vku.1 uc288vku.1 
ENSMUST00000239920.1 n-R5s127 ENSMUST00000239920.1 n-R5s127 (from geneSymbol) uc288vkv.1 uc288vkv.1 
ENSMUST00000239924.1 Gm23725 ENSMUST00000239924.1 Gm23725 (from geneSymbol) uc288vkw.1 uc288vkw.1 
ENSMUST00000239925.1 Gm22418 ENSMUST00000239925.1 Gm22418 (from geneSymbol) DQ558729 uc288vkx.1 uc288vkx.1 
ENSMUST00000239927.1 Gm23269 ENSMUST00000239927.1 Gm23269 (from geneSymbol) uc288vky.1 uc288vky.1 
ENSMUST00000239928.1 Gm24445 ENSMUST00000239928.1 Gm24445 (from geneSymbol) DQ558729 uc288vkz.1 uc288vkz.1 
ENSMUST00000239929.1 Gm22950 ENSMUST00000239929.1 Gm22950 (from geneSymbol) DQ558729 uc288vla.1 uc288vla.1 
ENSMUST00000239931.1 Gm23511 ENSMUST00000239931.1 Gm23511 (from geneSymbol) DQ548138 uc288vlb.1 uc288vlb.1 
ENSMUST00000239932.1 Gm23017 ENSMUST00000239932.1 Gm23017 (from geneSymbol) uc288vlc.1 uc288vlc.1 
ENSMUST00000239933.1 Mir467a-2 ENSMUST00000239933.1 microRNA 467a-2 (from RefSeq NR_037249.1) NR_037249 uc288vld.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610901.1, LM610904.1 [ECO:0000345] ##Evidence-Data-END## uc288vld.1 
ENSMUST00000239936.1 Snord116l12 ENSMUST00000239936.1 Snord116l12 (from geneSymbol) uc288vle.1 uc288vle.1 
ENSMUST00000239937.1 Gm25547 ENSMUST00000239937.1 Gm25547 (from geneSymbol) DQ558729 uc288vlf.1 uc288vlf.1 
ENSMUST00000239938.1 Gm23439 ENSMUST00000239938.1 Gm23439 (from geneSymbol) uc288vlg.1 uc288vlg.1 
ENSMUST00000239939.1 Gm25799 ENSMUST00000239939.1 Gm25799 (from geneSymbol) uc288vlh.1 uc288vlh.1 
ENSMUST00000239940.1 Mir669a-5 ENSMUST00000239940.1 microRNA 669a-5 (from RefSeq NR_037251.1) NR_037251 uc288vli.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vli.1 
ENSMUST00000239941.1 Gm25869 ENSMUST00000239941.1 Gm25869 (from geneSymbol) DQ558729 uc288vlj.1 uc288vlj.1 
ENSMUST00000239942.1 Gm22109 ENSMUST00000239942.1 predicted gene, 22109 (from RefSeq NR_046147.1) NR_046147 uc288vlk.1 uc288vlk.1 
ENSMUST00000239946.1 Gm26432 ENSMUST00000239946.1 Gm26432 (from geneSymbol) uc288vll.1 uc288vll.1 
ENSMUST00000239950.1 Gm22050 ENSMUST00000239950.1 Gm22050 (from geneSymbol) uc288vlm.1 uc288vlm.1 
ENSMUST00000239951.1 Gm25457 ENSMUST00000239951.1 Gm25457 (from geneSymbol) DQ558729 uc288vln.1 uc288vln.1 
ENSMUST00000239953.1 Gm26204 ENSMUST00000239953.1 Gm26204 (from geneSymbol) DQ558729 uc288vlo.1 uc288vlo.1 
ENSMUST00000239954.1 Mir669a-9 ENSMUST00000239954.1 microRNA 4669a-9 (from RefSeq NR_037260.1) NR_037260 uc288vlp.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vlp.1 
ENSMUST00000239955.1 Gm23265 ENSMUST00000239955.1 Gm23265 (from geneSymbol) uc288vlq.1 uc288vlq.1 
ENSMUST00000239959.1 Gm22630 ENSMUST00000239959.1 Gm22630 (from geneSymbol) uc288vlr.1 uc288vlr.1 
ENSMUST00000239960.1 Snord116l2 ENSMUST00000239960.1 small nucleolar RNA, C/D box 116-like 2 (from RefSeq NR_033779.1) NR_033779 uc288vls.1 uc288vls.1 
ENSMUST00000239962.1 Mir344i ENSMUST00000239962.1 microRNA 344i (from RefSeq NR_049204.1) NR_049204 uc288vlt.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611619.1 [ECO:0000345] ##Evidence-Data-END## uc288vlt.1 
ENSMUST00000239963.1 n-R5s102 ENSMUST00000239963.1 n-R5s102 (from geneSymbol) AB352120 uc288vlu.1 uc288vlu.1 
ENSMUST00000239964.1 Gm26392 ENSMUST00000239964.1 Gm26392 (from geneSymbol) uc288vlv.1 uc288vlv.1 
ENSMUST00000239966.1 Gm24693 ENSMUST00000239966.1 Gm24693 (from geneSymbol) DQ558729 uc288vlw.1 uc288vlw.1 
ENSMUST00000239967.1 Gm24260 ENSMUST00000239967.1 Gm24260 (from geneSymbol) DQ558729 uc288vlx.1 uc288vlx.1 
ENSMUST00000239968.1 Gm25583 ENSMUST00000239968.1 Gm25583 (from geneSymbol) DQ558729 uc288vly.1 uc288vly.1 
ENSMUST00000239969.1 n-R5s109 ENSMUST00000239969.1 n-R5s109 (from geneSymbol) AB352120 uc288vlz.1 uc288vlz.1 
ENSMUST00000239971.1 Gm23561 ENSMUST00000239971.1 Gm23561 (from geneSymbol) uc288vma.1 uc288vma.1 
ENSMUST00000239972.1 Mir6970 ENSMUST00000239972.1 microRNA 6970 (from RefSeq NR_105936.1) NR_105936 uc288vmb.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vmb.1 
ENSMUST00000239973.1 n-R5s144 ENSMUST00000239973.1 nuclear encoded rRNA 5S 144 (from RefSeq NR_046151.1) NR_046151 uc288vmc.1 uc288vmc.1 
ENSMUST00000239974.1 Gm24424 ENSMUST00000239974.1 Gm24424 (from geneSymbol) DQ558729 uc288vmd.1 uc288vmd.1 
ENSMUST00000239975.1 Gm22391 ENSMUST00000239975.1 Gm22391 (from geneSymbol) uc288vme.1 uc288vme.1 
ENSMUST00000239978.1 Gm23151 ENSMUST00000239978.1 Gm23151 (from geneSymbol) DQ558729 uc288vmf.1 uc288vmf.1 
ENSMUST00000239981.1 Gm23529 ENSMUST00000239981.1 Gm23529 (from geneSymbol) uc288vmg.1 uc288vmg.1 
ENSMUST00000239982.1 Gm22632 ENSMUST00000239982.1 Gm22632 (from geneSymbol) uc288vmh.1 uc288vmh.1 
ENSMUST00000239985.1 Gm22910 ENSMUST00000239985.1 Gm22910 (from geneSymbol) uc288vmi.1 uc288vmi.1 
ENSMUST00000239986.1 Gm24870 ENSMUST00000239986.1 Gm24870 (from geneSymbol) DQ558729 uc288vmj.1 uc288vmj.1 
ENSMUST00000239989.1 Gm22909 ENSMUST00000239989.1 Gm22909 (from geneSymbol) uc288vmk.1 uc288vmk.1 
ENSMUST00000239990.1 Snord116l1 ENSMUST00000239990.1 small nucleolar RNA, C/D box 116-like 1 (from RefSeq NR_033778.1) NR_033778 uc288vml.1 uc288vml.1 
ENSMUST00000239991.1 Gm25405 ENSMUST00000239991.1 Gm25405 (from geneSymbol) DQ558729 uc288vmm.1 uc288vmm.1 
ENSMUST00000239993.1 Gm23516 ENSMUST00000239993.1 Gm23516 (from geneSymbol) uc288vmn.1 uc288vmn.1 
ENSMUST00000239995.1 Gm26316 ENSMUST00000239995.1 Gm26316 (from geneSymbol) DQ551040 uc288vmo.1 uc288vmo.1 
ENSMUST00000239996.1 Gm26337 ENSMUST00000239996.1 Gm26337 (from geneSymbol) uc288vmp.1 uc288vmp.1 
ENSMUST00000240000.1 Gm24713 ENSMUST00000240000.1 Gm24713 (from geneSymbol) DQ558729 uc288vmq.1 uc288vmq.1 
ENSMUST00000240001.1 Gm25577 ENSMUST00000240001.1 Gm25577 (from geneSymbol) DQ558729 uc288vmr.1 uc288vmr.1 
ENSMUST00000240003.1 Snord50b ENSMUST00000240003.1 Snord50b (from geneSymbol) AB116376 uc288vms.1 uc288vms.1 
ENSMUST00000240005.1 Gm22069 ENSMUST00000240005.1 Gm22069 (from geneSymbol) uc288vmt.1 uc288vmt.1 
ENSMUST00000240007.1 Gm23452 ENSMUST00000240007.1 Gm23452 (from geneSymbol) DQ558729 uc288vmu.1 uc288vmu.1 
ENSMUST00000240009.1 Gm23002 ENSMUST00000240009.1 Gm23002 (from geneSymbol) uc288vmv.1 uc288vmv.1 
ENSMUST00000240010.1 Gm22063 ENSMUST00000240010.1 Gm22063 (from geneSymbol) DQ558729 uc288vmw.1 uc288vmw.1 
ENSMUST00000240011.1 Gm25818 ENSMUST00000240011.1 Gm25818 (from geneSymbol) AB353021 uc288vmx.1 uc288vmx.1 
ENSMUST00000240012.1 Snord116l17 ENSMUST00000240012.1 Snord116l17 (from geneSymbol) uc288vmy.1 uc288vmy.1 
ENSMUST00000240014.1 Gm22812 ENSMUST00000240014.1 Gm22812 (from geneSymbol) uc288vmz.1 uc288vmz.1 
ENSMUST00000240015.1 Gm26201 ENSMUST00000240015.1 Gm26201 (from geneSymbol) uc288vna.1 uc288vna.1 
ENSMUST00000240016.2 Gm24599 ENSMUST00000240016.2 Gm24599 (from geneSymbol) ENSMUST00000240016.1 uc288vnb.1 uc288vnb.1 
ENSMUST00000240017.1 Gm26317 ENSMUST00000240017.1 Gm26317 (from geneSymbol) DQ558729 uc288vnc.1 uc288vnc.1 
ENSMUST00000240018.1 Gm25929 ENSMUST00000240018.1 Gm25929 (from geneSymbol) uc288vnd.1 uc288vnd.1 
ENSMUST00000240020.1 Gm24759 ENSMUST00000240020.1 Gm24759 (from geneSymbol) uc288vne.1 uc288vne.1 
ENSMUST00000240023.1 Gm22347 ENSMUST00000240023.1 Gm22347 (from geneSymbol) uc288vnf.1 uc288vnf.1 
ENSMUST00000240024.1 n-R5s118 ENSMUST00000240024.1 n-R5s118 (from geneSymbol) AB349296 uc288vng.1 uc288vng.1 
ENSMUST00000240025.1 n-R5s115 ENSMUST00000240025.1 n-R5s115 (from geneSymbol) AB352987 uc288vnh.1 uc288vnh.1 
ENSMUST00000240026.1 Snord116l8 ENSMUST00000240026.1 Snord116l8 (from geneSymbol) uc288vni.1 uc288vni.1 
ENSMUST00000240027.1 n-R5s110 ENSMUST00000240027.1 nuclear encoded rRNA 5S 110 (from RefSeq NR_046124.1) NR_046124 uc288vnj.1 uc288vnj.1 
ENSMUST00000240028.1 Gm24206 ENSMUST00000240028.1 Gm24206 (from geneSymbol) uc288vnk.1 uc288vnk.1 
ENSMUST00000240030.1 Gm26230 ENSMUST00000240030.1 predicted gene, 26230 (from RefSeq NR_165412.1) NR_165412 uc288vnl.1 uc288vnl.1 
ENSMUST00000240035.1 Gm24652 ENSMUST00000240035.1 Gm24652 (from geneSymbol) uc288vnm.1 uc288vnm.1 
ENSMUST00000240037.1 Gm22912 ENSMUST00000240037.1 Gm22912 (from geneSymbol) uc288vnn.1 uc288vnn.1 
ENSMUST00000240040.1 Gm26421 ENSMUST00000240040.1 Gm26421 (from geneSymbol) uc288vno.1 uc288vno.1 
ENSMUST00000240041.1 Gm25939 ENSMUST00000240041.1 Gm25939 (from geneSymbol) DQ551040 uc288vnp.1 uc288vnp.1 
ENSMUST00000240042.1 Gm23721 ENSMUST00000240042.1 Gm23721 (from geneSymbol) DQ558729 uc288vnq.1 uc288vnq.1 
ENSMUST00000240043.1 Gm25127 ENSMUST00000240043.1 Gm25127 (from geneSymbol) DQ558729 uc288vnr.1 uc288vnr.1 
ENSMUST00000240044.1 Gm26324 ENSMUST00000240044.1 Gm26324 (from geneSymbol) DQ558729 uc288vns.1 uc288vns.1 
ENSMUST00000240046.1 Mir669a-11 ENSMUST00000240046.1 microRNA 669a-11 (from RefSeq NR_037266.1) NR_037266 uc288vnt.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vnt.1 
ENSMUST00000240047.1 Gm24021 ENSMUST00000240047.1 Gm24021 (from geneSymbol) uc288vnu.1 uc288vnu.1 
ENSMUST00000240048.1 Gm26062 ENSMUST00000240048.1 Gm26062 (from geneSymbol) uc288vnv.1 uc288vnv.1 
ENSMUST00000240049.1 Gm26058 ENSMUST00000240049.1 Gm26058 (from geneSymbol) DQ558729 uc288vnw.1 uc288vnw.1 
ENSMUST00000240052.2 Gm23552 ENSMUST00000240052.2 Gm23552 (from geneSymbol) ENSMUST00000240052.1 uc288vnx.1 uc288vnx.1 
ENSMUST00000240054.1 Gm22716 ENSMUST00000240054.1 Gm22716 (from geneSymbol) uc288vny.1 uc288vny.1 
ENSMUST00000240055.2 Gm24072 ENSMUST00000240055.2 Gm24072 (from geneSymbol) ENSMUST00000240055.1 uc288vnz.1 uc288vnz.1 
ENSMUST00000240056.1 Gm22623 ENSMUST00000240056.1 Gm22623 (from geneSymbol) DQ558729 uc288voa.1 uc288voa.1 
ENSMUST00000240057.1 Gm26059 ENSMUST00000240057.1 Gm26059 (from geneSymbol) uc288vob.1 uc288vob.1 
ENSMUST00000240059.1 Gm25739 ENSMUST00000240059.1 Gm25739 (from geneSymbol) uc288voc.1 uc288voc.1 
ENSMUST00000240060.1 Gm24458 ENSMUST00000240060.1 Gm24458 (from geneSymbol) DQ558729 uc288vod.1 uc288vod.1 
ENSMUST00000240061.1 Gm24969 ENSMUST00000240061.1 Gm24969 (from geneSymbol) uc288voe.1 uc288voe.1 
ENSMUST00000240063.1 Gm26499 ENSMUST00000240063.1 Gm26499 (from geneSymbol) uc288vof.1 uc288vof.1 
ENSMUST00000240065.1 Gm22513 ENSMUST00000240065.1 Gm22513 (from geneSymbol) AB349931 uc288vog.1 uc288vog.1 
ENSMUST00000240068.1 Gm22288 ENSMUST00000240068.1 Gm22288 (from geneSymbol) DQ558729 uc288voh.1 uc288voh.1 
ENSMUST00000240069.1 Gm23790 ENSMUST00000240069.1 Gm23790 (from geneSymbol) DQ558729 uc288voi.1 uc288voi.1 
ENSMUST00000240071.1 n-R5s93 ENSMUST00000240071.1 n-R5s93 (from geneSymbol) uc288voj.1 uc288voj.1 
ENSMUST00000240072.1 Gm25523 ENSMUST00000240072.1 Gm25523 (from geneSymbol) uc288vok.1 uc288vok.1 
ENSMUST00000240076.1 Gm25061 ENSMUST00000240076.1 Gm25061 (from geneSymbol) uc288vol.1 uc288vol.1 
ENSMUST00000240077.1 Gm24926 ENSMUST00000240077.1 Gm24926 (from geneSymbol) uc288vom.1 uc288vom.1 
ENSMUST00000240078.1 Gm22509 ENSMUST00000240078.1 Gm22509 (from geneSymbol) uc288von.1 uc288von.1 
ENSMUST00000240079.1 n-R5s60 ENSMUST00000240079.1 n-R5s60 (from geneSymbol) uc288voo.1 uc288voo.1 
ENSMUST00000240080.1 Gm24168 ENSMUST00000240080.1 Gm24168 (from geneSymbol) uc288vop.1 uc288vop.1 
ENSMUST00000240081.1 Gm25245 ENSMUST00000240081.1 Gm25245 (from geneSymbol) DQ558729 uc288voq.1 uc288voq.1 
ENSMUST00000240082.1 Gm25525 ENSMUST00000240082.1 Gm25525 (from geneSymbol) DQ558729 uc288vor.1 uc288vor.1 
ENSMUST00000240083.1 Gm25564 ENSMUST00000240083.1 Gm25564 (from geneSymbol) uc288vos.1 uc288vos.1 
ENSMUST00000240085.1 Gm23523 ENSMUST00000240085.1 Gm23523 (from geneSymbol) LF192995 uc288vot.1 uc288vot.1 
ENSMUST00000240086.1 Mir3470a ENSMUST00000240086.1 microRNA 3470a (from RefSeq NR_037301.1) NR_037301 uc288vou.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. uc288vou.1 
ENSMUST00000240089.1 Gm25018 ENSMUST00000240089.1 predicted gene, 25018 (from RefSeq NR_046127.1) NR_046127 uc288vov.1 uc288vov.1 
ENSMUST00000240090.1 Gm24264 ENSMUST00000240090.1 Gm24264 (from geneSymbol) uc288vow.1 uc288vow.1 
ENSMUST00000240093.1 n-R5s5 ENSMUST00000240093.1 n-R5s5 (from geneSymbol) uc288vox.1 uc288vox.1 
ENSMUST00000240094.1 Gm25291 ENSMUST00000240094.1 Gm25291 (from geneSymbol) LF198484 uc288voy.1 uc288voy.1 
ENSMUST00000240095.1 Gm24077 ENSMUST00000240095.1 Gm24077 (from geneSymbol) uc288voz.1 uc288voz.1 
ENSMUST00000240096.2 Gm23977 ENSMUST00000240096.2 Gm23977 (from geneSymbol) ENSMUST00000240096.1 uc288vpa.1 uc288vpa.1 
ENSMUST00000240098.1 Gm26366 ENSMUST00000240098.1 Gm26366 (from geneSymbol) uc288vpb.1 uc288vpb.1 
ENSMUST00000240100.1 Snord116l16 ENSMUST00000240100.1 Snord116l16 (from geneSymbol) uc288vpc.1 uc288vpc.1 
ENSMUST00000240101.1 Gm22640 ENSMUST00000240101.1 Gm22640 (from geneSymbol) uc288vpd.1 uc288vpd.1 
ENSMUST00000240104.1 Gm25868 ENSMUST00000240104.1 Gm25868 (from geneSymbol) uc288vpe.1 uc288vpe.1 
ENSMUST00000240105.1 Gm25085 ENSMUST00000240105.1 Gm25085 (from geneSymbol) uc288vpf.1 uc288vpf.1 
ENSMUST00000240106.1 Gm24722 ENSMUST00000240106.1 Gm24722 (from geneSymbol) DQ558729 uc288vpg.1 uc288vpg.1 
ENSMUST00000240107.1 Gm22911 ENSMUST00000240107.1 Gm22911 (from geneSymbol) DQ558729 uc288vph.1 uc288vph.1 
ENSMUST00000240108.1 Gm26378 ENSMUST00000240108.1 Gm26378 (from geneSymbol) DQ558729 uc288vpi.1 uc288vpi.1 
ENSMUST00000240109.1 Gm25742 ENSMUST00000240109.1 Gm25742 (from geneSymbol) uc288vpj.1 uc288vpj.1 
ENSMUST00000240110.1 n-R5s105 ENSMUST00000240110.1 nuclear encoded rRNA 5S 105 (from RefSeq NR_046122.1) NR_046122 uc288vpk.1 uc288vpk.1 
ENSMUST00000240112.1 n-R5s138 ENSMUST00000240112.1 nuclear encoded rRNA 5S 138 (from RefSeq NR_046145.1) NR_046145 uc288vpl.1 uc288vpl.1 
ENSMUST00000240114.1 Gm24407 ENSMUST00000240114.1 Gm24407 (from geneSymbol) M10328 uc288vpm.1 uc288vpm.1 
ENSMUST00000240115.1 Gm26501 ENSMUST00000240115.1 Gm26501 (from geneSymbol) uc288vpn.1 uc288vpn.1 
ENSMUST00000240118.1 Gm22550 ENSMUST00000240118.1 Gm22550 (from geneSymbol) uc288vpo.1 uc288vpo.1 
ENSMUST00000240119.1 Gm22114 ENSMUST00000240119.1 Gm22114 (from geneSymbol) DQ558729 uc288vpp.1 uc288vpp.1 
ENSMUST00000240122.1 Gm24702 ENSMUST00000240122.1 Gm24702 (from geneSymbol) uc288vpq.1 uc288vpq.1 
ENSMUST00000240125.1 Gm24417 ENSMUST00000240125.1 Gm24417 (from geneSymbol) uc288vpr.1 uc288vpr.1 
ENSMUST00000240128.1 Gm24760 ENSMUST00000240128.1 Gm24760 (from geneSymbol) uc288vps.1 uc288vps.1 
ENSMUST00000240129.1 Gm23410 ENSMUST00000240129.1 Gm23410 (from geneSymbol) LF204950 uc288vpt.1 uc288vpt.1 
ENSMUST00000240132.1 Gm22941 ENSMUST00000240132.1 Gm22941 (from geneSymbol) uc288vpu.1 uc288vpu.1 
ENSMUST00000240133.1 n-R5s128 ENSMUST00000240133.1 nuclear encoded rRNA 5S 128 (from RefSeq NR_046134.1) NR_046134 uc288vpv.1 uc288vpv.1 
ENSMUST00000240134.1 Mir467a-4 ENSMUST00000240134.1 microRNA 467a-4 (from RefSeq NR_037254.1) NR_037254 uc288vpw.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vpw.1 
ENSMUST00000240135.1 Gm24968 ENSMUST00000240135.1 Gm24968 (from geneSymbol) DQ558729 uc288vpx.1 uc288vpx.1 
ENSMUST00000240136.1 Gm23379 ENSMUST00000240136.1 Gm23379 (from geneSymbol) uc288vpy.1 uc288vpy.1 
ENSMUST00000240137.1 Gm23575 ENSMUST00000240137.1 Gm23575 (from geneSymbol) uc288vpz.1 uc288vpz.1 
ENSMUST00000240138.1 Gm25450 ENSMUST00000240138.1 Gm25450 (from geneSymbol) DQ558729 uc288vqa.1 uc288vqa.1 
ENSMUST00000240139.1 Gm24182 ENSMUST00000240139.1 Gm24182 (from geneSymbol) DQ558729 uc288vqb.1 uc288vqb.1 
ENSMUST00000240140.1 Gm22274 ENSMUST00000240140.1 Gm22274 (from geneSymbol) uc288vqc.1 uc288vqc.1 
ENSMUST00000240144.1 Gm25452 ENSMUST00000240144.1 Gm25452 (from geneSymbol) uc288vqd.1 uc288vqd.1 
ENSMUST00000240145.1 Gm24950 ENSMUST00000240145.1 Gm24950 (from geneSymbol) FM991916 uc288vqe.1 uc288vqe.1 
ENSMUST00000240146.1 Gm25851 ENSMUST00000240146.1 Gm25851 (from geneSymbol) uc288vqf.1 uc288vqf.1 
ENSMUST00000240152.1 Gm25944 ENSMUST00000240152.1 Gm25944 (from geneSymbol) uc288vqg.1 uc288vqg.1 
ENSMUST00000240153.1 Gm23567 ENSMUST00000240153.1 Gm23567 (from geneSymbol) uc288vqh.1 uc288vqh.1 
ENSMUST00000240154.1 Gm22255 ENSMUST00000240154.1 Gm22255 (from geneSymbol) uc288vqi.1 uc288vqi.1 
ENSMUST00000240157.1 Gm22417 ENSMUST00000240157.1 Gm22417 (from geneSymbol) uc288vqj.1 uc288vqj.1 
ENSMUST00000240158.1 Gm25211 ENSMUST00000240158.1 Gm25211 (from geneSymbol) DQ558729 uc288vqk.1 uc288vqk.1 
ENSMUST00000240159.1 Gm23449 ENSMUST00000240159.1 Gm23449 (from geneSymbol) uc288vql.1 uc288vql.1 
ENSMUST00000240160.1 Gm25473 ENSMUST00000240160.1 Gm25473 (from geneSymbol) DQ558729 uc288vqm.1 uc288vqm.1 
ENSMUST00000240161.1 Gm24829 ENSMUST00000240161.1 Gm24829 (from geneSymbol) uc288vqn.1 uc288vqn.1 
ENSMUST00000240162.1 Gm23446 ENSMUST00000240162.1 Gm23446 (from geneSymbol) uc288vqo.1 uc288vqo.1 
ENSMUST00000240163.1 Gm25101 ENSMUST00000240163.1 Gm25101 (from geneSymbol) DQ558729 uc288vqp.1 uc288vqp.1 
ENSMUST00000240164.1 Gm26179 ENSMUST00000240164.1 Gm26179 (from geneSymbol) uc288vqq.1 uc288vqq.1 
ENSMUST00000240165.1 Gm22392 ENSMUST00000240165.1 Gm22392 (from geneSymbol) uc288vqr.1 uc288vqr.1 
ENSMUST00000240166.1 n-R5s112 ENSMUST00000240166.1 n-R5s112 (from geneSymbol) AB349563 uc288vqs.1 uc288vqs.1 
ENSMUST00000240167.1 Rnu6 ENSMUST00000240167.1 U6 small nuclear RNA (from RefSeq NR_003027.2) NR_003027 uc288vqt.1 uc288vqt.1 
ENSMUST00000240168.1 Gm26107 ENSMUST00000240168.1 Gm26107 (from geneSymbol) DQ558729 uc288vqu.1 uc288vqu.1 
ENSMUST00000240170.1 Gm22511 ENSMUST00000240170.1 Gm22511 (from geneSymbol) uc288vqv.1 uc288vqv.1 
ENSMUST00000240171.1 Gm25684 ENSMUST00000240171.1 Gm25684 (from geneSymbol) uc288vqw.1 uc288vqw.1 
ENSMUST00000240172.1 Mir680-2 ENSMUST00000240172.1 microRNA 680-2 (from RefSeq NR_030448.1) NR_030448 uc288vqx.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vqx.1 
ENSMUST00000240177.1 Gm24305 ENSMUST00000240177.1 Gm24305 (from geneSymbol) FM991912 uc288vqy.1 uc288vqy.1 
ENSMUST00000240179.1 Gm24657 ENSMUST00000240179.1 Gm24657 (from geneSymbol) uc288vqz.1 uc288vqz.1 
ENSMUST00000240181.1 Gm24569 ENSMUST00000240181.1 Gm24569 (from geneSymbol) uc288vra.1 uc288vra.1 
ENSMUST00000240182.1 Gm24486 ENSMUST00000240182.1 Gm24486 (from geneSymbol) DQ558729 uc288vrb.1 uc288vrb.1 
ENSMUST00000240185.1 Gm24540 ENSMUST00000240185.1 Gm24540 (from geneSymbol) DQ558729 uc288vrc.1 uc288vrc.1 
ENSMUST00000240186.1 Gm22756 ENSMUST00000240186.1 Gm22756 (from geneSymbol) DQ558729 uc288vrd.1 uc288vrd.1 
ENSMUST00000240187.1 Gm26434 ENSMUST00000240187.1 Gm26434 (from geneSymbol) uc288vre.1 uc288vre.1 
ENSMUST00000240188.1 n-R5s71 ENSMUST00000240188.1 n-R5s71 (from geneSymbol) AB350652 uc288vrf.1 uc288vrf.1 
ENSMUST00000240189.1 Gm23141 ENSMUST00000240189.1 Gm23141 (from geneSymbol) uc288vrg.1 uc288vrg.1 
ENSMUST00000240190.1 n-R5s122 ENSMUST00000240190.1 nuclear encoded rRNA 5S 122 (from RefSeq NR_046130.1) NR_046130 uc288vrh.1 uc288vrh.1 
ENSMUST00000240191.1 Gm22988 ENSMUST00000240191.1 Gm22988 (from geneSymbol) uc288vri.1 uc288vri.1 
ENSMUST00000240192.1 Gm25585 ENSMUST00000240192.1 Gm25585 (from geneSymbol) uc288vrj.1 uc288vrj.1 
ENSMUST00000240193.1 Gm25077 ENSMUST00000240193.1 Gm25077 (from geneSymbol) uc288vrk.1 uc288vrk.1 
ENSMUST00000240194.1 Gm22439 ENSMUST00000240194.1 Gm22439 (from geneSymbol) uc288vrl.1 uc288vrl.1 
ENSMUST00000240195.1 Gm25230 ENSMUST00000240195.1 Gm25230 (from geneSymbol) uc288vrm.1 uc288vrm.1 
ENSMUST00000240196.1 Gm23846 ENSMUST00000240196.1 Gm23846 (from geneSymbol) uc288vrn.1 uc288vrn.1 
ENSMUST00000240198.1 Gm22631 ENSMUST00000240198.1 Gm22631 (from geneSymbol) uc288vro.1 uc288vro.1 
ENSMUST00000240200.1 Gm23143 ENSMUST00000240200.1 Gm23143 (from geneSymbol) DQ561416 uc288vrp.1 uc288vrp.1 
ENSMUST00000240201.1 n-R5s149 ENSMUST00000240201.1 nuclear encoded rRNA 5S 149 (from RefSeq NR_046156.1) NR_046156 uc288vrq.1 uc288vrq.1 
ENSMUST00000240203.2 Gm24712 ENSMUST00000240203.2 Gm24712 (from geneSymbol) ENSMUST00000240203.1 uc288vrr.1 uc288vrr.1 
ENSMUST00000240204.1 Gm23139 ENSMUST00000240204.1 Gm23139 (from geneSymbol) uc288vrs.1 uc288vrs.1 
ENSMUST00000240206.1 Mir3472 ENSMUST00000240206.1 microRNA 3472 (from RefSeq NR_037309.1) NR_037309 uc288vrt.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vrt.1 
ENSMUST00000240207.1 n-R5s141 ENSMUST00000240207.1 nuclear encoded rRNA 5S 141 (from RefSeq NR_046148.1) NR_046148 uc288vru.1 uc288vru.1 
ENSMUST00000240209.1 Gm23520 ENSMUST00000240209.1 Gm23520 (from geneSymbol) DQ558729 uc288vrv.1 uc288vrv.1 
ENSMUST00000240210.1 Gm22258 ENSMUST00000240210.1 Gm22258 (from geneSymbol) uc288vrw.1 uc288vrw.1 
ENSMUST00000240212.1 Gm26096 ENSMUST00000240212.1 Gm26096 (from geneSymbol) uc288vrx.1 uc288vrx.1 
ENSMUST00000240213.1 Gm24862 ENSMUST00000240213.1 Gm24862 (from geneSymbol) uc288vry.1 uc288vry.1 
ENSMUST00000240214.1 Mir669a-1 ENSMUST00000240214.1 microRNA 669a-1 (from RefSeq NR_035408.1) NR_035408 uc288vrz.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vrz.1 
ENSMUST00000240216.1 Gm25221 ENSMUST00000240216.1 Gm25221 (from geneSymbol) uc288vsa.1 uc288vsa.1 
ENSMUST00000240217.1 Gm24584 ENSMUST00000240217.1 Gm24584 (from geneSymbol) DQ558729 uc288vsb.1 uc288vsb.1 
ENSMUST00000240218.2 Gm54451 ENSMUST00000240218.2 Gm54451 (from geneSymbol) ENSMUST00000240218.1 LF230031 uc288vsc.1 uc288vsc.1 
ENSMUST00000240219.1 Gm26367 ENSMUST00000240219.1 Gm26367 (from geneSymbol) uc288vsd.1 uc288vsd.1 
ENSMUST00000240223.1 Gm23305 ENSMUST00000240223.1 Gm23305 (from geneSymbol) uc288vse.1 uc288vse.1 
ENSMUST00000240225.1 Gm24465 ENSMUST00000240225.1 Gm24465 (from geneSymbol) uc288vsf.1 uc288vsf.1 
ENSMUST00000240226.1 Snord50a ENSMUST00000240226.1 Snord50a (from geneSymbol) uc288vsg.1 uc288vsg.1 
ENSMUST00000240228.1 Gm23619 ENSMUST00000240228.1 Gm23619 (from geneSymbol) uc288vsh.1 uc288vsh.1 
ENSMUST00000240229.1 Gm22295 ENSMUST00000240229.1 Gm22295 (from geneSymbol) DQ558729 uc288vsi.1 uc288vsi.1 
ENSMUST00000240231.1 Rnu2-10 ENSMUST00000240231.1 U2 small nuclear RNA 10 (from RefSeq NR_004414.1) NR_004414 uc288vsj.1 uc288vsj.1 
ENSMUST00000240232.1 Mir467a-3 ENSMUST00000240232.1 microRNA 467a-3 (from RefSeq NR_037252.1) NR_037252 uc288vsk.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vsk.1 
ENSMUST00000240233.1 Gm23618 ENSMUST00000240233.1 Gm23618 (from geneSymbol) uc288vsl.1 uc288vsl.1 
ENSMUST00000240234.1 Snord116l15 ENSMUST00000240234.1 Snord116l15 (from geneSymbol) uc288vsm.1 uc288vsm.1 
ENSMUST00000240235.1 n-R5s111 ENSMUST00000240235.1 nuclear encoded rRNA 5S 111 (from RefSeq NR_046125.1) NR_046125 uc288vsn.1 uc288vsn.1 
ENSMUST00000240236.1 n-R5s134 ENSMUST00000240236.1 nuclear encoded rRNA 5S 134 (from RefSeq NR_046143.1) NR_046143 uc288vso.1 uc288vso.1 
ENSMUST00000240239.1 Mir466b-4 ENSMUST00000240239.1 microRNA 466b-4 (from RefSeq NR_130336.1) NR_130336 uc288vsp.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vsp.1 
ENSMUST00000240240.1 Mir7679 ENSMUST00000240240.1 microRNA 7679 (from RefSeq NR_106144.1) NR_106144 uc288vsq.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vsq.1 
ENSMUST00000240241.1 Gm25597 ENSMUST00000240241.1 Gm25597 (from geneSymbol) uc288vsr.1 uc288vsr.1 
ENSMUST00000240242.1 Gm26297 ENSMUST00000240242.1 Gm26297 (from geneSymbol) uc288vss.1 uc288vss.1 
ENSMUST00000240243.1 Gm24418 ENSMUST00000240243.1 Gm24418 (from geneSymbol) uc288vst.1 uc288vst.1 
ENSMUST00000240244.1 Gm24639 ENSMUST00000240244.1 Gm24639 (from geneSymbol) uc288vsu.1 uc288vsu.1 
ENSMUST00000240248.1 Gm23440 ENSMUST00000240248.1 Gm23440 (from geneSymbol) uc288vsv.1 uc288vsv.1 
ENSMUST00000240249.1 Gm25350 ENSMUST00000240249.1 Gm25350 (from geneSymbol) uc288vsw.1 uc288vsw.1 
ENSMUST00000240250.2 Gm26072 ENSMUST00000240250.2 Gm26072 (from geneSymbol) ENSMUST00000240250.1 uc288vsx.1 uc288vsx.1 
ENSMUST00000240251.1 Gm22749 ENSMUST00000240251.1 Gm22749 (from geneSymbol) DQ558729 uc288vsy.1 uc288vsy.1 
ENSMUST00000240252.1 Gm22259 ENSMUST00000240252.1 Gm22259 (from geneSymbol) DQ558729 uc288vsz.1 uc288vsz.1 
ENSMUST00000240253.1 Snord3b1 ENSMUST00000240253.1 small nucleolar RNA, C/D box 3B1 (from RefSeq NR_004415.1) NR_004415 uc288vta.1 uc288vta.1 
ENSMUST00000240255.1 Gm22307 ENSMUST00000240255.1 Gm22307 (from geneSymbol) uc288vtb.1 uc288vtb.1 
ENSMUST00000240256.1 Gm26270 ENSMUST00000240256.1 Gm26270 (from geneSymbol) uc288vtc.1 uc288vtc.1 
ENSMUST00000240258.1 Gm23216 ENSMUST00000240258.1 Gm23216 (from geneSymbol) uc288vtd.1 uc288vtd.1 
ENSMUST00000240259.1 Mir467a-8 ENSMUST00000240259.1 microRNA 467a-8 (from RefSeq NR_037263.1) NR_037263 uc288vte.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vte.1 
ENSMUST00000240260.1 Gm24656 ENSMUST00000240260.1 Gm24656 (from geneSymbol) uc288vtf.1 uc288vtf.1 
ENSMUST00000240263.1 Gm26200 ENSMUST00000240263.1 Gm26200 (from geneSymbol) uc288vtg.1 uc288vtg.1 
ENSMUST00000240264.1 Gm23264 ENSMUST00000240264.1 Gm23264 (from geneSymbol) uc288vth.1 uc288vth.1 
ENSMUST00000240265.1 Gm23296 ENSMUST00000240265.1 Gm23296 (from geneSymbol) DQ558729 uc288vti.1 uc288vti.1 
ENSMUST00000240269.1 Gm25936 ENSMUST00000240269.1 Gm25936 (from geneSymbol) uc288vtj.1 uc288vtj.1 
ENSMUST00000240270.1 Gm26433 ENSMUST00000240270.1 Gm26433 (from geneSymbol) uc288vtk.1 uc288vtk.1 
ENSMUST00000240272.1 Gm25312 ENSMUST00000240272.1 Gm25312 (from geneSymbol) DQ558729 uc288vtl.1 uc288vtl.1 
ENSMUST00000240273.1 Gm25212 ENSMUST00000240273.1 predicted gene, 25212 (from RefSeq NR_046152.1) NR_046152 uc288vtm.1 uc288vtm.1 
ENSMUST00000240274.1 Gm22130 ENSMUST00000240274.1 Gm22130 (from geneSymbol) uc288vtn.1 uc288vtn.1 
ENSMUST00000240275.1 Gm26488 ENSMUST00000240275.1 Gm26488 (from geneSymbol) uc288vto.1 uc288vto.1 
ENSMUST00000240276.1 Mir683-2 ENSMUST00000240276.1 microRNA 683-2 (from RefSeq NR_030647.1) NR_030647 uc288vtp.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vtp.1 
ENSMUST00000240277.2 Gm22608 ENSMUST00000240277.2 Gm22608 (from geneSymbol) ENSMUST00000240277.1 uc288vtq.1 uc288vtq.1 
ENSMUST00000240281.1 Gm24027 ENSMUST00000240281.1 predicted gene, 24027 (from RefSeq NR_165495.1) NR_165495 uc288vtr.1 uc288vtr.1 
ENSMUST00000240282.1 Gm25466 ENSMUST00000240282.1 Gm25466 (from geneSymbol) uc288vts.1 uc288vts.1 
ENSMUST00000240284.1 Gm22003 ENSMUST00000240284.1 Gm22003 (from geneSymbol) DQ558729 uc288vtt.1 uc288vtt.1 
ENSMUST00000240287.1 Gm26444 ENSMUST00000240287.1 Gm26444 (from geneSymbol) FM991912 uc288vtu.1 uc288vtu.1 
ENSMUST00000240289.1 Gm24218 ENSMUST00000240289.1 Gm24218 (from geneSymbol) uc288vtv.1 uc288vtv.1 
ENSMUST00000240290.1 Gm24707 ENSMUST00000240290.1 Gm24707 (from geneSymbol) uc288vtw.1 uc288vtw.1 
ENSMUST00000240291.1 Gm23714 ENSMUST00000240291.1 Gm23714 (from geneSymbol) uc288vtx.1 uc288vtx.1 
ENSMUST00000240292.1 Gm25474 ENSMUST00000240292.1 Gm25474 (from geneSymbol) uc288vty.1 uc288vty.1 
ENSMUST00000240294.1 Gm23816 ENSMUST00000240294.1 Gm23816 (from geneSymbol) uc288vtz.1 uc288vtz.1 
ENSMUST00000240295.1 Gm24414 ENSMUST00000240295.1 Gm24414 (from geneSymbol) DQ558729 uc288vua.1 uc288vua.1 
ENSMUST00000240296.1 Gm23261 ENSMUST00000240296.1 Gm23261 (from geneSymbol) LF193662 uc288vub.1 uc288vub.1 
ENSMUST00000240298.1 Gm23682 ENSMUST00000240298.1 Gm23682 (from geneSymbol) uc288vuc.1 uc288vuc.1 
ENSMUST00000240300.1 Mir6382 ENSMUST00000240300.1 microRNA 6382 (from RefSeq NR_105803.1) NR_105803 uc288vud.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vud.1 
ENSMUST00000240302.1 Gm22044 ENSMUST00000240302.1 Gm22044 (from geneSymbol) DQ558729 uc288vue.1 uc288vue.1 
ENSMUST00000240303.1 Gm24538 ENSMUST00000240303.1 Gm24538 (from geneSymbol) DQ558729 uc288vuf.1 uc288vuf.1 
ENSMUST00000240304.1 Gm22170 ENSMUST00000240304.1 Gm22170 (from geneSymbol) DQ558729 uc288vug.1 uc288vug.1 
ENSMUST00000240305.1 Gm25209 ENSMUST00000240305.1 Gm25209 (from geneSymbol) uc288vuh.1 uc288vuh.1 
ENSMUST00000240308.1 n-R5s101 ENSMUST00000240308.1 n-R5s101 (from geneSymbol) AB352282 uc288vui.1 uc288vui.1 
ENSMUST00000240310.1 Gm24570 ENSMUST00000240310.1 Gm24570 (from geneSymbol) uc288vuj.1 uc288vuj.1 
ENSMUST00000240311.1 Gm25790 ENSMUST00000240311.1 Gm25790 (from geneSymbol) DQ558729 uc288vuk.1 uc288vuk.1 
ENSMUST00000240313.1 Gm25709 ENSMUST00000240313.1 Gm25709 (from geneSymbol) DQ558729 uc288vul.1 uc288vul.1 
ENSMUST00000240314.1 Gm23310 ENSMUST00000240314.1 Gm23310 (from geneSymbol) uc288vum.1 uc288vum.1 
ENSMUST00000240315.1 Gm22780 ENSMUST00000240315.1 Gm22780 (from geneSymbol) uc288vun.1 uc288vun.1 
ENSMUST00000240316.1 Gm25326 ENSMUST00000240316.1 Gm25326 (from geneSymbol) DQ558729 uc288vuo.1 uc288vuo.1 
ENSMUST00000240318.1 Snord116l7 ENSMUST00000240318.1 Snord116l7 (from geneSymbol) uc288vup.1 uc288vup.1 
ENSMUST00000240319.1 Gm26054 ENSMUST00000240319.1 Gm26054 (from geneSymbol) DQ558729 uc288vuq.1 uc288vuq.1 
ENSMUST00000240320.1 Gm25074 ENSMUST00000240320.1 Gm25074 (from geneSymbol) uc288vur.1 uc288vur.1 
ENSMUST00000240321.1 Mir669k ENSMUST00000240321.1 microRNA 669k (from RefSeq NR_035410.1) NR_035410 uc288vus.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM610084.1 [ECO:0000345] ##Evidence-Data-END## uc288vus.1 
ENSMUST00000240322.1 Gm23727 ENSMUST00000240322.1 Gm23727 (from geneSymbol) uc288vut.1 uc288vut.1 
ENSMUST00000240323.2 Gm25617 ENSMUST00000240323.2 Gm25617 (from geneSymbol) AF357391 ENSMUST00000240323.1 uc288vuu.1 uc288vuu.1 
ENSMUST00000240324.1 Snord116l3 ENSMUST00000240324.1 Snord116l3 (from geneSymbol) uc288vuv.1 uc288vuv.1 
ENSMUST00000240328.1 Gm25412 ENSMUST00000240328.1 Gm25412 (from geneSymbol) uc288vuw.1 uc288vuw.1 
ENSMUST00000240329.1 Gm24856 ENSMUST00000240329.1 Gm24856 (from geneSymbol) DQ558729 uc288vux.1 uc288vux.1 
ENSMUST00000240330.1 Gm24019 ENSMUST00000240330.1 Gm24019 (from geneSymbol) DQ558729 uc288vuy.1 uc288vuy.1 
ENSMUST00000240332.1 Gm25710 ENSMUST00000240332.1 Gm25710 (from geneSymbol) uc288vuz.1 uc288vuz.1 
ENSMUST00000240336.2 Gm56067 ENSMUST00000240336.2 Gm56067 (from geneSymbol) ENSMUST00000240336.1 uc288vva.1 uc288vva.1 
ENSMUST00000240338.1 n-R5s100 ENSMUST00000240338.1 nuclear encoded rRNA 5S 100 (from RefSeq NR_046118.1) NR_046118 uc288vvb.1 uc288vvb.1 
ENSMUST00000240339.1 n-R5s209 ENSMUST00000240339.1 n-R5s209 (from geneSymbol) uc288vvc.1 uc288vvc.1 
ENSMUST00000240340.1 Gm23568 ENSMUST00000240340.1 Gm23568 (from geneSymbol) uc288vvd.1 uc288vvd.1 
ENSMUST00000240341.1 Gm24220 ENSMUST00000240341.1 Gm24220 (from geneSymbol) uc288vve.1 uc288vve.1 
ENSMUST00000240342.1 Gm24306 ENSMUST00000240342.1 Gm24306 (from geneSymbol) uc288vvf.1 uc288vvf.1 
ENSMUST00000240343.1 Mir3470b ENSMUST00000240343.1 microRNA 3470b (from RefSeq NR_037302.1) NR_037302 uc288vvg.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vvg.1 
ENSMUST00000240344.1 Gm22393 ENSMUST00000240344.1 Gm22393 (from geneSymbol) uc288vvh.1 uc288vvh.1 
ENSMUST00000240345.1 Gm26055 ENSMUST00000240345.1 Gm26055 (from geneSymbol) uc288vvi.1 uc288vvi.1 
ENSMUST00000240347.1 Gm23948 ENSMUST00000240347.1 Gm23948 (from geneSymbol) uc288vvj.1 uc288vvj.1 
ENSMUST00000240348.1 Gm24137 ENSMUST00000240348.1 Gm24137 (from geneSymbol) uc288vvk.1 uc288vvk.1 
ENSMUST00000240350.1 Gm23815 ENSMUST00000240350.1 Gm23815 (from geneSymbol) DQ558729 uc288vvl.1 uc288vvl.1 
ENSMUST00000240351.2 Gm55288 ENSMUST00000240351.2 Gm55288 (from geneSymbol) ENSMUST00000240351.1 LF262441 uc288vvm.1 uc288vvm.1 
ENSMUST00000240354.1 Gm24416 ENSMUST00000240354.1 Gm24416 (from geneSymbol) uc288vvn.1 uc288vvn.1 
ENSMUST00000240356.1 Gm22449 ENSMUST00000240356.1 Gm22449 (from geneSymbol) uc288vvo.1 uc288vvo.1 
ENSMUST00000240359.1 Gm22863 ENSMUST00000240359.1 Gm22863 (from geneSymbol) uc288vvp.1 uc288vvp.1 
ENSMUST00000240361.1 Gm23512 ENSMUST00000240361.1 Gm23512 (from geneSymbol) DQ558729 uc288vvq.1 uc288vvq.1 
ENSMUST00000240362.1 Gm23003 ENSMUST00000240362.1 Gm23003 (from geneSymbol) uc288vvr.1 uc288vvr.1 
ENSMUST00000240365.1 Gm25698 ENSMUST00000240365.1 Gm25698 (from geneSymbol) DQ558729 uc288vvs.1 uc288vvs.1 
ENSMUST00000240368.1 Gm26334 ENSMUST00000240368.1 Gm26334 (from geneSymbol) uc288vvt.1 uc288vvt.1 
ENSMUST00000240369.1 Gm22821 ENSMUST00000240369.1 Gm22821 (from geneSymbol) DQ558729 uc288vvu.1 uc288vvu.1 
ENSMUST00000240370.1 n-R5s117 ENSMUST00000240370.1 nuclear encoded rRNA 5S 117 (from RefSeq NR_046128.1) NR_046128 uc288vvv.1 uc288vvv.1 
ENSMUST00000240373.1 Mir669a-8 ENSMUST00000240373.1 microRNA 669a-8 (from RefSeq NR_037259.1) NR_037259 uc288vvw.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vvw.1 
ENSMUST00000240374.1 n-R5s125 ENSMUST00000240374.1 n-R5s125 (from geneSymbol) DQ545504 uc288vvx.1 uc288vvx.1 
ENSMUST00000240375.1 Gm25448 ENSMUST00000240375.1 Gm25448 (from geneSymbol) DQ558729 uc288vvy.1 uc288vvy.1 
ENSMUST00000240377.1 Rn18s-rs5 ENSMUST00000240377.1 Rn18s-rs5 (from geneSymbol) NR_003278 uc288vvz.1 The sequences coding for ribosomal RNAs are present as rDNA repeating units distributed on chromosomes 12, 15, 16, 18 and 19. A 45S rRNA, which serves as the precursor for the 18S, 5.8S and 28S rRNA, is transcribed from each rDNA unit by RNA polymerase I. The number of rDNA repeating units varies between individuals and from chromosome to chromosome, although usually 30 to 40 repeats are found on each chromosome. These rDNA repeats are not currently annotated on the reference genome. This gene represents the portion of one rDNA repeat which encodes a 18S rRNA. [provided by RefSeq, Jan 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. uc288vvz.1 
ENSMUST00000240378.1 Gm24456 ENSMUST00000240378.1 Gm24456 (from geneSymbol) DQ558729 uc288vwa.1 uc288vwa.1 
ENSMUST00000240379.1 Gm23971 ENSMUST00000240379.1 Gm23971 (from geneSymbol) FM991916 uc288vwb.1 uc288vwb.1 
ENSMUST00000240380.1 Gm23610 ENSMUST00000240380.1 Gm23610 (from geneSymbol) DQ558729 uc288vwc.1 uc288vwc.1 
ENSMUST00000240382.1 Gm26389 ENSMUST00000240382.1 Gm26389 (from geneSymbol) uc288vwd.1 uc288vwd.1 
ENSMUST00000240383.1 Mir467a-7 ENSMUST00000240383.1 microRNA 467a-7 (from RefSeq NR_037261.1) NR_037261 uc288vwe.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vwe.1 
ENSMUST00000240384.1 Gm23648 ENSMUST00000240384.1 Gm23648 (from geneSymbol) DQ558729 uc288vwf.1 uc288vwf.1 
ENSMUST00000240385.1 Gm22887 ENSMUST00000240385.1 Gm22887 (from geneSymbol) DQ558729 uc288vwg.1 uc288vwg.1 
ENSMUST00000240387.1 Gm25648 ENSMUST00000240387.1 Gm25648 (from geneSymbol) uc288vwh.1 uc288vwh.1 
ENSMUST00000240388.1 Gm24566 ENSMUST00000240388.1 Gm24566 (from geneSymbol) uc288vwi.1 uc288vwi.1 
ENSMUST00000240393.1 Mir713 ENSMUST00000240393.1 microRNA 713 (from RefSeq NR_030493.1) NR_030493 uc288vwj.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vwj.1 
ENSMUST00000240394.1 Gm26335 ENSMUST00000240394.1 Gm26335 (from geneSymbol) DQ558729 uc288vwk.1 uc288vwk.1 
ENSMUST00000240396.1 Gm25793 ENSMUST00000240396.1 Gm25793 (from geneSymbol) DQ558729 uc288vwl.1 uc288vwl.1 
ENSMUST00000240397.1 Gm24312 ENSMUST00000240397.1 Gm24312 (from geneSymbol) AB349296 uc288vwm.1 uc288vwm.1 
ENSMUST00000240399.1 Gm24262 ENSMUST00000240399.1 Gm24262 (from geneSymbol) uc288vwn.1 uc288vwn.1 
ENSMUST00000240401.1 Gm26071 ENSMUST00000240401.1 Gm26071 (from geneSymbol) DQ558729 uc288vwo.1 uc288vwo.1 
ENSMUST00000240405.1 Gm25360 ENSMUST00000240405.1 Gm25360 (from geneSymbol) DQ562105 uc288vwp.1 uc288vwp.1 
ENSMUST00000240408.1 Gm22448 ENSMUST00000240408.1 Gm22448 (from geneSymbol) DQ558729 uc288vwq.1 uc288vwq.1 
ENSMUST00000240411.1 n-R5s2 ENSMUST00000240411.1 n-R5s2 (from geneSymbol) AB349563 uc288vwr.1 uc288vwr.1 
ENSMUST00000240413.1 Snord116l11 ENSMUST00000240413.1 Snord116l11 (from geneSymbol) uc288vws.1 uc288vws.1 
ENSMUST00000240414.1 Gm23355 ENSMUST00000240414.1 Gm23355 (from geneSymbol) DQ558729 uc288vwt.1 uc288vwt.1 
ENSMUST00000240416.1 Gm22580 ENSMUST00000240416.1 Gm22580 (from geneSymbol) DQ558729 uc288vwu.1 uc288vwu.1 
ENSMUST00000240417.1 Gm22260 ENSMUST00000240417.1 Gm22260 (from geneSymbol) uc288vwv.1 uc288vwv.1 
ENSMUST00000240419.1 Gm22286 ENSMUST00000240419.1 Gm22286 (from geneSymbol) DQ558729 uc288vww.1 uc288vww.1 
ENSMUST00000240421.1 Gm25175 ENSMUST00000240421.1 Gm25175 (from geneSymbol) uc288vwx.1 uc288vwx.1 
ENSMUST00000240423.1 Gm22886 ENSMUST00000240423.1 Gm22886 (from geneSymbol) DQ558729 uc288vwy.1 uc288vwy.1 
ENSMUST00000240424.1 Gm24967 ENSMUST00000240424.1 Gm24967 (from geneSymbol) DQ558729 uc288vwz.1 uc288vwz.1 
ENSMUST00000240425.1 Gm24866 ENSMUST00000240425.1 Gm24866 (from geneSymbol) AF357427 uc288vxa.1 uc288vxa.1 
ENSMUST00000240426.1 Snord116l10 ENSMUST00000240426.1 Snord116l10 (from geneSymbol) uc288vxb.1 uc288vxb.1 
ENSMUST00000240428.1 Gm23922 ENSMUST00000240428.1 Gm23922 (from geneSymbol) uc288vxc.1 uc288vxc.1 
ENSMUST00000240429.1 Gm24641 ENSMUST00000240429.1 Gm24641 (from geneSymbol) DQ558729 uc288vxd.1 uc288vxd.1 
ENSMUST00000240430.1 Gm24863 ENSMUST00000240430.1 Gm24863 (from geneSymbol) DQ558729 uc288vxe.1 uc288vxe.1 
ENSMUST00000240433.1 Gm24242 ENSMUST00000240433.1 Gm24242 (from geneSymbol) DQ558729 uc288vxf.1 uc288vxf.1 
ENSMUST00000240437.1 Gm24799 ENSMUST00000240437.1 Gm24799 (from geneSymbol) uc288vxg.1 uc288vxg.1 
ENSMUST00000240438.1 Rnu1b2 ENSMUST00000240438.1 U1b2 small nuclear RNA (from RefSeq NR_024200.3) NR_024200 uc288vxh.1 uc288vxh.1 
ENSMUST00000240439.1 Gm25098 ENSMUST00000240439.1 Gm25098 (from geneSymbol) uc288vxi.1 uc288vxi.1 
ENSMUST00000240441.2 Gm24676 ENSMUST00000240441.2 Gm24676 (from geneSymbol) ENSMUST00000240441.1 uc288vxj.1 uc288vxj.1 
ENSMUST00000240442.1 Gm25146 ENSMUST00000240442.1 Gm25146 (from geneSymbol) uc288vxk.1 uc288vxk.1 
ENSMUST00000240443.1 Gm24310 ENSMUST00000240443.1 Gm24310 (from geneSymbol) uc288vxl.1 uc288vxl.1 
ENSMUST00000240444.1 Gm24040 ENSMUST00000240444.1 Gm24040 (from geneSymbol) uc288vxm.1 uc288vxm.1 
ENSMUST00000240445.1 Gm26430 ENSMUST00000240445.1 Gm26430 (from geneSymbol) uc288vxn.1 uc288vxn.1 
ENSMUST00000240447.1 Gm24039 ENSMUST00000240447.1 Gm24039 (from geneSymbol) uc288vxo.1 uc288vxo.1 
ENSMUST00000240448.1 Gm25516 ENSMUST00000240448.1 Gm25516 (from geneSymbol) DQ558729 uc288vxp.1 uc288vxp.1 
ENSMUST00000240449.1 Gm22291 ENSMUST00000240449.1 predicted gene, 22291 (from RefSeq NR_046154.1) NR_046154 uc288vxq.1 uc288vxq.1 
ENSMUST00000240451.1 Gm24495 ENSMUST00000240451.1 Gm24495 (from geneSymbol) uc288vxr.1 uc288vxr.1 
ENSMUST00000240452.1 Gm23862 ENSMUST00000240452.1 Gm23862 (from geneSymbol) uc288vxs.1 uc288vxs.1 
ENSMUST00000240458.1 Mir466c-3 ENSMUST00000240458.1 predicted gene, 25285 (from RefSeq NR_130344.1) NR_130344 uc288vxt.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vxt.1 
ENSMUST00000240459.1 Gm24100 ENSMUST00000240459.1 Gm24100 (from geneSymbol) uc288vxu.1 uc288vxu.1 
ENSMUST00000240462.1 Gm25253 ENSMUST00000240462.1 Gm25253 (from geneSymbol) uc288vxv.1 uc288vxv.1 
ENSMUST00000240464.1 Gm23660 ENSMUST00000240464.1 Gm23660 (from geneSymbol) uc288vxw.1 uc288vxw.1 
ENSMUST00000240467.1 Gm25414 ENSMUST00000240467.1 Gm25414 (from geneSymbol) uc288vxx.1 uc288vxx.1 
ENSMUST00000240469.1 n-R5s136 ENSMUST00000240469.1 nuclear encoded rRNA 5S 136 (from RefSeq NR_046144.1) NR_046144 uc288vxy.1 uc288vxy.1 
ENSMUST00000240470.1 Gm24861 ENSMUST00000240470.1 Gm24861 (from geneSymbol) DQ558729 uc288vxz.1 uc288vxz.1 
ENSMUST00000240472.1 Gm22252 ENSMUST00000240472.1 Gm22252 (from geneSymbol) uc288vya.1 uc288vya.1 
ENSMUST00000240473.1 Gm26465 ENSMUST00000240473.1 Gm26465 (from geneSymbol) DQ558729 uc288vyb.1 uc288vyb.1 
ENSMUST00000240474.1 Gm22246 ENSMUST00000240474.1 Gm22246 (from geneSymbol) DQ558729 uc288vyc.1 uc288vyc.1 
ENSMUST00000240475.1 Gm24415 ENSMUST00000240475.1 Gm24415 (from geneSymbol) uc288vyd.1 uc288vyd.1 
ENSMUST00000240476.1 Gm24283 ENSMUST00000240476.1 Gm24283 (from geneSymbol) uc288vye.1 uc288vye.1 
ENSMUST00000240477.1 Gm22682 ENSMUST00000240477.1 Gm22682 (from geneSymbol) DQ558729 uc288vyf.1 uc288vyf.1 
ENSMUST00000240480.1 Gm24199 ENSMUST00000240480.1 Gm24199 (from geneSymbol) uc288vyg.1 uc288vyg.1 
ENSMUST00000240482.1 Gm23089 ENSMUST00000240482.1 Gm23089 (from geneSymbol) uc288vyh.1 uc288vyh.1 
ENSMUST00000240483.1 Gm23471 ENSMUST00000240483.1 Gm23471 (from geneSymbol) uc288vyi.1 uc288vyi.1 
ENSMUST00000240487.1 Mir467a-10 ENSMUST00000240487.1 microRNA 467a-10 (from RefSeq NR_037267.1) NR_037267 uc288vyj.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vyj.1 
ENSMUST00000240489.1 Gm26422 ENSMUST00000240489.1 Gm26422 (from geneSymbol) uc288vyk.1 uc288vyk.1 
ENSMUST00000240491.1 Gm26188 ENSMUST00000240491.1 Gm26188 (from geneSymbol) uc288vyl.1 uc288vyl.1 
ENSMUST00000240493.1 Mir683-1 ENSMUST00000240493.1 microRNA 683-1 (from RefSeq NR_030453.1) NR_030453 uc288vym.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vym.1 
ENSMUST00000240494.1 Mir6375 ENSMUST00000240494.1 microRNA 6375 (from RefSeq NR_105794.1) NR_105794 uc288vyn.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vyn.1 
ENSMUST00000240495.1 Gm25670 ENSMUST00000240495.1 Gm25670 (from geneSymbol) DQ558729 uc288vyo.1 uc288vyo.1 
ENSMUST00000240496.1 Gm26498 ENSMUST00000240496.1 Gm26498 (from geneSymbol) uc288vyp.1 uc288vyp.1 
ENSMUST00000240499.1 Gm22111 ENSMUST00000240499.1 Gm22111 (from geneSymbol) uc288vyq.1 uc288vyq.1 
ENSMUST00000240501.1 Rnu1a1 ENSMUST00000240501.1 U1a1 small nuclear RNA (from RefSeq NR_004411.3) NR_004411 uc288vyr.1 uc288vyr.1 
ENSMUST00000240505.1 Gm23286 ENSMUST00000240505.1 Gm23286 (from geneSymbol) uc288vys.1 uc288vys.1 
ENSMUST00000240506.1 n-R5s108 ENSMUST00000240506.1 nuclear encoded rRNA 5S 108 (from RefSeq NR_046123.1) NR_046123 uc288vyt.1 uc288vyt.1 
ENSMUST00000240507.1 Snord116l14 ENSMUST00000240507.1 Snord116l14 (from geneSymbol) uc288vyu.1 uc288vyu.1 
ENSMUST00000240509.1 n-R5s146 ENSMUST00000240509.1 nuclear encoded rRNA 5S 146 (from RefSeq NR_046153.1) NR_046153 uc288vyv.1 uc288vyv.1 
ENSMUST00000240510.1 Rnu1b6 ENSMUST00000240510.1 U1b6 small nuclear RNA (from RefSeq NR_004413.2) NR_004413 uc288vyw.1 uc288vyw.1 
ENSMUST00000240511.1 Gm25064 ENSMUST00000240511.1 Gm25064 (from geneSymbol) DQ558729 uc288vyx.1 uc288vyx.1 
ENSMUST00000240512.1 Gm25021 ENSMUST00000240512.1 Gm25021 (from geneSymbol) DQ558729 uc288vyy.1 uc288vyy.1 
ENSMUST00000240513.1 Gm23103 ENSMUST00000240513.1 Gm23103 (from geneSymbol) DQ558729 uc288vyz.1 uc288vyz.1 
ENSMUST00000240514.1 Gm22995 ENSMUST00000240514.1 Gm22995 (from geneSymbol) DQ558729 uc288vza.1 uc288vza.1 
ENSMUST00000240515.1 Gm23687 ENSMUST00000240515.1 Gm23687 (from geneSymbol) uc288vzb.1 uc288vzb.1 
ENSMUST00000240516.1 Gm26135 ENSMUST00000240516.1 Gm26135 (from geneSymbol) AB116376 uc288vzc.1 uc288vzc.1 
ENSMUST00000240517.1 Gm24859 ENSMUST00000240517.1 Gm24859 (from geneSymbol) DQ558729 uc288vzd.1 uc288vzd.1 
ENSMUST00000240518.1 Gm23267 ENSMUST00000240518.1 Gm23267 (from geneSymbol) uc288vze.1 uc288vze.1 
ENSMUST00000240522.1 Gm24803 ENSMUST00000240522.1 Gm24803 (from geneSymbol) DQ558729 uc288vzf.1 uc288vzf.1 
ENSMUST00000240523.1 Gm25874 ENSMUST00000240523.1 Gm25874 (from geneSymbol) uc288vzg.1 uc288vzg.1 
ENSMUST00000240525.1 Gm22061 ENSMUST00000240525.1 Gm22061 (from geneSymbol) uc288vzh.1 uc288vzh.1 
ENSMUST00000240526.1 Gm23145 ENSMUST00000240526.1 Gm23145 (from geneSymbol) uc288vzi.1 uc288vzi.1 
ENSMUST00000240528.1 Gm26336 ENSMUST00000240528.1 Gm26336 (from geneSymbol) uc288vzj.1 uc288vzj.1 
ENSMUST00000240529.1 Snord116l5 ENSMUST00000240529.1 Snord116l5 (from geneSymbol) uc288vzk.1 uc288vzk.1 
ENSMUST00000240531.1 Gm23506 ENSMUST00000240531.1 Gm23506 (from geneSymbol) DQ558729 uc288vzl.1 uc288vzl.1 
ENSMUST00000240532.1 Gm22996 ENSMUST00000240532.1 Gm22996 (from geneSymbol) uc288vzm.1 uc288vzm.1 
ENSMUST00000240534.1 Gm22092 ENSMUST00000240534.1 Gm22092 (from geneSymbol) DQ558729 uc288vzn.1 uc288vzn.1 
ENSMUST00000240535.1 Gm23849 ENSMUST00000240535.1 Gm23849 (from geneSymbol) FM991916 uc288vzo.1 uc288vzo.1 
ENSMUST00000240537.1 n-R5s104 ENSMUST00000240537.1 nuclear encoded rRNA 5S 104 (from RefSeq NR_046120.1) NR_046120 uc288vzp.1 uc288vzp.1 
ENSMUST00000240539.1 Idi1 ENSMUST00000240539.1 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (from UniProt P58044) AK132073 IDI1_MOUSE P58044 Q4FJU2 uc316ijd.1 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Reaction=isopentenyl diphosphate = dimethylallyl diphosphate; Xref=Rhea:RHEA:23284, ChEBI:CHEBI:57623, ChEBI:CHEBI:128769; EC=5.3.3.2; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit. ; Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1. Monomer. Peroxisome Belongs to the IPP isomerase type 1 family. magnesium ion binding isopentenyl-diphosphate delta-isomerase activity mitochondrion peroxisome lipid metabolic process steroid biosynthetic process cholesterol biosynthetic process steroid metabolic process cholesterol metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process sterol biosynthetic process hydrolase activity isomerase activity manganese ion binding response to stilbenoid metal ion binding dimethylallyl diphosphate biosynthetic process uc316ijd.1 
ENSMUST00000240547.1 Gadl1 ENSMUST00000240547.1 Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence= (from UniProt A0A8Q0QWL6) A0A8Q0QWL6 A0A8Q0QWL6_MOUSE BC052327 Gadl1 uc316ijl.1 Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence= Homodimer. Belongs to the group II decarboxylase family. uc316ijl.1 
ENSMUST00000240550.1 Potefam1 ENSMUST00000240550.1 Potefam1 (from geneSymbol) A0A8V5KX55 A0A8V5KX55_MOUSE AK015247 Potefam1 uc316ijd.1 uc316ijd.1 
ENSMUST00000240584.1 Gm14461 ENSMUST00000240584.1 Gm14461 (from geneSymbol) AK044135 uc316ikk.1 uc316ikk.1 
ENSMUST00000240712.1 Vmn2r120 ENSMUST00000240712.1 vomeronasal 2, receptor 120 (from RefSeq NM_001385181.1) A0A8V5KX69 A0A8V5KX69_MOUSE NM_001385181 Vmn2r120 uc316ipi.1 Cell membrane ; Multi-pass membrane protein Membrane ; Multi-pass membrane protein uc316ipi.1 
ENSMUST00000240722.1 Myo9b ENSMUST00000240722.1 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (from UniProt A0A8V5KX73) A0A8V5KX73 A0A8V5KX73_MOUSE AF143683 Myo9b uc316ips.1 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. uc316ips.1 
ENSMUST00000240724.1 Gm56924 ENSMUST00000240724.1 Gm56924 (from geneSymbol) A0A8V5KY98 A0A8V5KY98_MOUSE D87325 Gm56924 uc316ipu.1 uc316ipu.1 
ENSMUST00000240726.1 Gm12610 ENSMUST00000240726.1 predicted gene 12610 (from RefSeq NR_132431.1) NR_132431 uc316ipw.1 uc316ipw.1 
ENSMUST00000240758.1 Ksr2 ENSMUST00000240758.1 Ksr2 (from geneSymbol) A0A8V5L0Q6 A0A8V5L0Q6_MOUSE BC068233 Ksr2 uc316irc.1 uc316irc.1 
ENSMUST00000240759.1 Kynu ENSMUST00000240759.1 kynureninase, transcript variant 4 (from RefSeq NM_001398676.1) KYNU_MOUSE NM_001398676 Q9CXF0 uc316ird.1 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Reaction=H2O + L-kynurenine = anthranilate + H(+) + L-alanine; Xref=Rhea:RHEA:16813, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16567, ChEBI:CHEBI:57959, ChEBI:CHEBI:57972; EC=3.7.1.3; Evidence=; Reaction=3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine; Xref=Rhea:RHEA:25143, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:36559, ChEBI:CHEBI:57972, ChEBI:CHEBI:58125; EC=3.7.1.3; Evidence= Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. Homodimer. Cytoplasm, cytosol No visible phenotype. Mice were born at the expected Mendelian ratio and are normal. They however show very high levels of L-3-hydroxykynurenine compared to wild-type mice. Belongs to the kynureninase family. Sequence=BAB29386.2; Type=Erroneous initiation; Evidence=; Sequence=BAC34035.1; Type=Erroneous initiation; Evidence=; catalytic activity nucleoplasm cytoplasm mitochondrion cytosol tryptophan catabolic process NAD biosynthetic process hydrolase activity pyridine nucleotide biosynthetic process tryptophan catabolic process to kynurenine tryptophan catabolic process to acetyl-CoA quinolinate biosynthetic process pyridoxal phosphate binding kynureninase activity response to interferon-gamma 'de novo' NAD biosynthetic process from tryptophan response to vitamin B6 protein homodimerization activity anthranilate metabolic process L-kynurenine catabolic process uc316ird.1 
ENSMUST00000240763.2 Gm57119 ENSMUST00000240763.2 Gm57119 (from geneSymbol) ENSMUST00000240763.1 LF219657 uc316irh.1 uc316irh.2 uc316irh.1 uc316irh.2 
ENSMUST00000240766.2 Gm56785 ENSMUST00000240766.2 Gm56785 (from geneSymbol) ENSMUST00000240766.1 uc316irk.1 uc316irk.2 uc316irk.1 uc316irk.2 
ENSMUST00000240775.2 Gm57144 ENSMUST00000240775.2 Gm57144 (from geneSymbol) ENSMUST00000240775.1 LF192764 uc316irt.1 uc316irt.2 uc316irt.1 uc316irt.2 
ENSMUST00000240776.2 Gm57301 ENSMUST00000240776.2 Gm57301 (from geneSymbol) ENSMUST00000240776.1 LF202598 uc316iru.1 uc316iru.2 uc316iru.1 uc316iru.2 
ENSMUST00000240782.2 Gm57269 ENSMUST00000240782.2 Gm57269 (from geneSymbol) ENSMUST00000240782.1 uc316isa.1 uc316isa.2 uc316isa.1 uc316isa.2 
ENSMUST00000240790.2 Gm40787 ENSMUST00000240790.2 Gm40787 (from geneSymbol) ENSMUST00000240790.1 uc316isi.1 uc316isi.2 uc316isi.1 uc316isi.2 
ENSMUST00000240791.2 Epb41l4aos ENSMUST00000240791.2 Epb41l4aos (from geneSymbol) AK010403 ENSMUST00000240791.1 uc316isj.1 uc316isj.2 uc316isj.1 uc316isj.2 
ENSMUST00000240806.2 Gm9054 ENSMUST00000240806.2 predicted gene 9054 (from RefSeq NR_045872.1) ENSMUST00000240806.1 NR_045872 uc316isy.1 uc316isy.2 uc316isy.1 uc316isy.2 
ENSMUST00000240812.2 Gm57374 ENSMUST00000240812.2 Gm57374 (from geneSymbol) ENSMUST00000240812.1 LF198414 uc316ite.1 uc316ite.2 uc316ite.1 uc316ite.2 
ENSMUST00000240816.2 Gm57234 ENSMUST00000240816.2 Gm57234 (from geneSymbol) ENSMUST00000240816.1 uc316iti.1 uc316iti.2 uc316iti.1 uc316iti.2 
ENSMUST00000240857.1 A230072C01Rik ENSMUST00000240857.1 A230072C01Rik (from geneSymbol) AK038883 uc316iux.1 uc316iux.1 
ENSMUST00000240861.2 2610020C07Rik ENSMUST00000240861.2 2610020C07Rik (from geneSymbol) AK029005 ENSMUST00000240861.1 uc316ivb.1 uc316ivb.2 uc316ivb.1 uc316ivb.2 
ENSMUST00000240876.2 Gm56615 ENSMUST00000240876.2 Gm56615 (from geneSymbol) ENSMUST00000240876.1 uc316ivq.1 uc316ivq.2 uc316ivq.1 uc316ivq.2 
ENSMUST00000240877.2 Gm56747 ENSMUST00000240877.2 Gm56747 (from geneSymbol) ENSMUST00000240877.1 uc316ivr.1 uc316ivr.2 uc316ivr.1 uc316ivr.2 
ENSMUST00000240896.2 9530004M14Rik ENSMUST00000240896.2 9530004M14Rik (from geneSymbol) AK020542 ENSMUST00000240896.1 uc316iwk.1 uc316iwk.2 uc316iwk.1 uc316iwk.2 
ENSMUST00000240924.1 2900052L18Rik ENSMUST00000240924.1 RIKEN cDNA 2900052L18 gene (from RefSeq NR_151480.1) NR_151480 uc316ixm.1 uc316ixm.1 
ENSMUST00000240933.2 Gm56570 ENSMUST00000240933.2 Gm56570 (from geneSymbol) ENSMUST00000240933.1 uc316ixv.1 uc316ixv.2 uc316ixv.1 uc316ixv.2 
ENSMUST00000240940.2 Lppos ENSMUST00000240940.2 Lppos (from geneSymbol) AK039760 ENSMUST00000240940.1 uc316iyc.1 uc316iyc.2 uc316iyc.1 uc316iyc.2 
ENSMUST00000240950.2 5430427G11Rik ENSMUST00000240950.2 5430427G11Rik (from geneSymbol) ENSMUST00000240950.1 uc316iym.1 uc316iym.2 uc316iym.1 uc316iym.2 
ENSMUST00000240957.2 Gm56635 ENSMUST00000240957.2 Gm56635 (from geneSymbol) ENSMUST00000240957.1 uc316iyt.1 uc316iyt.2 uc316iyt.1 uc316iyt.2 
ENSMUST00000240959.1 Gm32085 ENSMUST00000240959.1 Gm32085 (from geneSymbol) uc316iyv.1 uc316iyv.1 
ENSMUST00000240965.2 Gm57286 ENSMUST00000240965.2 Gm57286 (from geneSymbol) ENSMUST00000240965.1 LF204225 uc316izb.1 uc316izb.2 uc316izb.1 uc316izb.2 
ENSMUST00000240982.2 Gm57192 ENSMUST00000240982.2 Gm57192 (from geneSymbol) ENSMUST00000240982.1 uc316izr.1 uc316izr.2 uc316izr.1 uc316izr.2 
ENSMUST00000240989.2 Gm57201 ENSMUST00000240989.2 Gm57201 (from geneSymbol) ENSMUST00000240989.1 LF196534 uc316izy.1 uc316izy.2 uc316izy.1 uc316izy.2 
ENSMUST00000240994.2 Gm56752 ENSMUST00000240994.2 Gm56752 (from geneSymbol) ENSMUST00000240994.1 uc316jad.1 uc316jad.2 uc316jad.1 uc316jad.2 
ENSMUST00000240996.1 Redrum ENSMUST00000240996.1 Redrum (from geneSymbol) KF703538 uc316jaf.1 uc316jaf.1 
ENSMUST00000240999.2 2810030D12Rik ENSMUST00000240999.2 2810030D12Rik (from geneSymbol) AK019250 ENSMUST00000240999.1 uc316jai.1 uc316jai.2 uc316jai.1 uc316jai.2 
ENSMUST00000241018.2 Gm56639 ENSMUST00000241018.2 Gm56639 (from geneSymbol) ENSMUST00000241018.1 uc316jbb.1 uc316jbb.2 uc316jbb.1 uc316jbb.2 
ENSMUST00000241023.2 Gm36220 ENSMUST00000241023.2 Gm36220 (from geneSymbol) ENSMUST00000241023.1 uc316jbg.1 uc316jbg.2 uc316jbg.1 uc316jbg.2 
ENSMUST00000241032.2 Gm56691 ENSMUST00000241032.2 Gm56691 (from geneSymbol) ENSMUST00000241032.1 uc316jbp.1 uc316jbp.2 uc316jbp.1 uc316jbp.2 
ENSMUST00000241055.2 Gm57373 ENSMUST00000241055.2 Gm57373 (from geneSymbol) ENSMUST00000241055.1 uc316jcm.1 uc316jcm.2 uc316jcm.1 uc316jcm.2 
ENSMUST00000241057.2 Gm56942 ENSMUST00000241057.2 Gm56942 (from geneSymbol) ENSMUST00000241057.1 uc316jco.1 uc316jco.2 uc316jco.1 uc316jco.2 
ENSMUST00000241062.2 Gm56489 ENSMUST00000241062.2 Gm56489 (from geneSymbol) ENSMUST00000241062.1 uc316jct.1 uc316jct.2 uc316jct.1 uc316jct.2 
ENSMUST00000241069.1 Gm56824 ENSMUST00000241069.1 Gm56824 (from geneSymbol) uc316jda.1 uc316jda.1 
ENSMUST00000241076.2 Gm57071 ENSMUST00000241076.2 Gm57071 (from geneSymbol) ENSMUST00000241076.1 uc316jdh.1 uc316jdh.2 uc316jdh.1 uc316jdh.2 
ENSMUST00000241079.2 Gm56926 ENSMUST00000241079.2 Gm56926 (from geneSymbol) AK052913 ENSMUST00000241079.1 uc316jdk.1 uc316jdk.2 uc316jdk.1 uc316jdk.2 
ENSMUST00000241080.2 Gm11454 ENSMUST00000241080.2 predicted gene 11454 (from RefSeq NR_166402.1) ENSMUST00000241080.1 NR_166402 uc316jdl.1 uc316jdl.2 uc316jdl.1 uc316jdl.2 
ENSMUST00000241081.2 Gm56488 ENSMUST00000241081.2 Gm56488 (from geneSymbol) AK157751 ENSMUST00000241081.1 uc316jdm.1 uc316jdm.2 uc316jdm.1 uc316jdm.2 
ENSMUST00000241093.2 Gm57085 ENSMUST00000241093.2 Gm57085 (from geneSymbol) ENSMUST00000241093.1 uc316jdy.1 uc316jdy.2 uc316jdy.1 uc316jdy.2 
ENSMUST00000241095.2 Gm57416 ENSMUST00000241095.2 Gm57416 (from geneSymbol) ENSMUST00000241095.1 uc316jea.1 uc316jea.2 uc316jea.1 uc316jea.2 
ENSMUST00000241103.2 Gm57017 ENSMUST00000241103.2 Gm57017 (from geneSymbol) ENSMUST00000241103.1 uc316jei.1 uc316jei.2 uc316jei.1 uc316jei.2 
ENSMUST00000241110.2 Gm57417 ENSMUST00000241110.2 Gm57417 (from geneSymbol) ENSMUST00000241110.1 uc316jep.1 uc316jep.2 uc316jep.1 uc316jep.2 
ENSMUST00000241128.2 Gm57109 ENSMUST00000241128.2 Gm57109 (from geneSymbol) ENSMUST00000241128.1 LF192654 uc316jfg.1 uc316jfg.2 uc316jfg.1 uc316jfg.2 
ENSMUST00000241131.2 6230426M11Rik ENSMUST00000241131.2 6230426M11Rik (from geneSymbol) AK134511 ENSMUST00000241131.1 uc316jfj.1 uc316jfj.2 uc316jfj.1 uc316jfj.2 
ENSMUST00000241132.1 Gm33046 ENSMUST00000241132.1 Gm33046 (from geneSymbol) uc316jfk.1 uc316jfk.1 
ENSMUST00000241136.2 Gm57214 ENSMUST00000241136.2 Gm57214 (from geneSymbol) ENSMUST00000241136.1 uc316jfo.1 uc316jfo.2 uc316jfo.1 uc316jfo.2 
ENSMUST00000241148.2 Gm56956 ENSMUST00000241148.2 Gm56956 (from geneSymbol) ENSMUST00000241148.1 uc316jga.1 uc316jga.2 uc316jga.1 uc316jga.2 
ENSMUST00000241161.2 1700007L15Rik ENSMUST00000241161.2 1700007L15Rik (from geneSymbol) AK160141 ENSMUST00000241161.1 uc316jgn.1 uc316jgn.2 uc316jgn.1 uc316jgn.2 
ENSMUST00000241176.2 Gm46732 ENSMUST00000241176.2 Gm46732 (from geneSymbol) BC053491 ENSMUST00000241176.1 uc316jhc.1 uc316jhc.2 uc316jhc.1 uc316jhc.2 
ENSMUST00000241179.2 Gm56964 ENSMUST00000241179.2 Gm56964 (from geneSymbol) ENSMUST00000241179.1 uc316jhf.1 uc316jhf.2 uc316jhf.1 uc316jhf.2 
ENSMUST00000241188.2 Gm56692 ENSMUST00000241188.2 Gm56692 (from geneSymbol) AK131847 ENSMUST00000241188.1 uc316jho.1 uc316jho.2 uc316jho.1 uc316jho.2 
ENSMUST00000241189.1 Gm56823 ENSMUST00000241189.1 Gm56823 (from geneSymbol) uc316jhp.1 uc316jhp.1 
ENSMUST00000241208.1 4833418N02Rik ENSMUST00000241208.1 4833418N02Rik (from geneSymbol) AK031641 uc316jii.1 uc316jii.1 
ENSMUST00000241218.2 Gm56647 ENSMUST00000241218.2 Gm56647 (from geneSymbol) ENSMUST00000241218.1 uc316jis.1 uc316jis.2 uc316jis.1 uc316jis.2 
ENSMUST00000241226.2 Gm56719 ENSMUST00000241226.2 Gm56719 (from geneSymbol) ENSMUST00000241226.1 uc316jja.1 uc316jja.2 uc316jja.1 uc316jja.2 
ENSMUST00000241234.2 Gm56598 ENSMUST00000241234.2 Gm56598 (from geneSymbol) ENSMUST00000241234.1 uc316jji.1 uc316jji.2 uc316jji.1 uc316jji.2 
ENSMUST00000241248.2 Gm56631 ENSMUST00000241248.2 Gm56631 (from geneSymbol) ENSMUST00000241248.1 uc316jjw.1 uc316jjw.2 uc316jjw.1 uc316jjw.2 
ENSMUST00000241261.2 Gm56608 ENSMUST00000241261.2 Gm56608 (from geneSymbol) AK141820 ENSMUST00000241261.1 uc316jkg.1 uc316jkg.2 uc316jkg.1 uc316jkg.2 
ENSMUST00000241271.1 Gm57354 ENSMUST00000241271.1 Gm57354 (from geneSymbol) AK162101 uc316jkq.1 uc316jkq.1 
ENSMUST00000241274.2 Gm56622 ENSMUST00000241274.2 Gm56622 (from geneSymbol) ENSMUST00000241274.1 uc316jks.1 uc316jks.2 uc316jks.1 uc316jks.2 
ENSMUST00000241282.2 5430416N02Rik ENSMUST00000241282.2 5430416N02Rik (from geneSymbol) ENSMUST00000241282.1 KY468050 uc316jkz.1 uc316jkz.2 uc316jkz.1 uc316jkz.2 
ENSMUST00000241289.2 2700099C18Rik ENSMUST00000241289.2 2700099C18Rik (from geneSymbol) AK132724 ENSMUST00000241289.1 uc316jlg.1 uc316jlg.2 uc316jlg.1 uc316jlg.2 
ENSMUST00000241294.2 Gm32803 ENSMUST00000241294.2 Gm32803 (from geneSymbol) ENSMUST00000241294.1 uc316jll.1 uc316jll.2 uc316jll.1 uc316jll.2 
ENSMUST00000241297.2 Gm56594 ENSMUST00000241297.2 Gm56594 (from geneSymbol) ENSMUST00000241297.1 uc316jlo.1 uc316jlo.2 uc316jlo.1 uc316jlo.2 
ENSMUST00000241298.2 Mir133a-1hg ENSMUST00000241298.2 Mir133a-1hg (from geneSymbol) ENSMUST00000241298.1 uc316jlp.1 uc316jlp.2 uc316jlp.1 uc316jlp.2 
ENSMUST00000241317.1 Gm15663 ENSMUST00000241317.1 Gm15663 (from geneSymbol) AK034146 uc316jmh.1 uc316jmh.1 
ENSMUST00000241355.2 Gm57432 ENSMUST00000241355.2 Gm57432 (from geneSymbol) ENSMUST00000241355.1 uc316jnt.1 uc316jnt.2 uc316jnt.1 uc316jnt.2 
ENSMUST00000241359.1 Gm57107 ENSMUST00000241359.1 Gm57107 (from geneSymbol) LF192875 uc316jnx.1 uc316jnx.1 
ENSMUST00000241362.2 Gm56546 ENSMUST00000241362.2 Gm56546 (from geneSymbol) ENSMUST00000241362.1 uc316joa.1 uc316joa.2 uc316joa.1 uc316joa.2 
ENSMUST00000241384.2 D030045P18Rik ENSMUST00000241384.2 D030045P18Rik (from geneSymbol) AK080062 ENSMUST00000241384.1 uc316jow.1 uc316jow.2 uc316jow.1 uc316jow.2 
ENSMUST00000241405.2 Gm57117 ENSMUST00000241405.2 Gm57117 (from geneSymbol) ENSMUST00000241405.1 uc316jpr.1 uc316jpr.2 uc316jpr.1 uc316jpr.2 
ENSMUST00000241407.2 Gm57066 ENSMUST00000241407.2 Gm57066 (from geneSymbol) ENSMUST00000241407.1 uc316jpt.1 uc316jpt.2 uc316jpt.1 uc316jpt.2 
ENSMUST00000241437.2 Fam120aos ENSMUST00000241437.2 family with sequence similarity 120A, opposite strand (from RefSeq NR_015601.1) ENSMUST00000241437.1 NR_015601 uc316jqx.1 uc316jqx.2 uc316jqx.1 uc316jqx.2 
ENSMUST00000241439.2 Gm57330 ENSMUST00000241439.2 Gm57330 (from geneSymbol) ENSMUST00000241439.1 uc316jqz.1 uc316jqz.2 uc316jqz.1 uc316jqz.2 
ENSMUST00000241472.2 Gm36914 ENSMUST00000241472.2 Gm36914 (from geneSymbol) ENSMUST00000241472.1 uc316jsg.1 uc316jsg.2 uc316jsg.1 uc316jsg.2 
ENSMUST00000241486.1 Gm30961 ENSMUST00000241486.1 Gm30961 (from geneSymbol) uc316jsu.1 uc316jsu.1 
ENSMUST00000241487.2 Gm57067 ENSMUST00000241487.2 Gm57067 (from geneSymbol) DQ564435 ENSMUST00000241487.1 uc316jsv.1 uc316jsv.2 uc316jsv.1 uc316jsv.2 
ENSMUST00000241490.2 Gm57194 ENSMUST00000241490.2 Gm57194 (from geneSymbol) ENSMUST00000241490.1 uc316jsy.1 uc316jsy.2 uc316jsy.1 uc316jsy.2 
ENSMUST00000241491.1 Gm50076 ENSMUST00000241491.1 Gm50076 (from geneSymbol) uc316jsz.1 uc316jsz.1 
ENSMUST00000241492.2 Gm57108 ENSMUST00000241492.2 Gm57108 (from geneSymbol) ENSMUST00000241492.1 uc316jta.1 uc316jta.2 uc316jta.1 uc316jta.2 
ENSMUST00000241507.2 Gm56604 ENSMUST00000241507.2 Gm56604 (from geneSymbol) ENSMUST00000241507.1 LF200632 uc316jtp.1 uc316jtp.2 uc316jtp.1 uc316jtp.2 
ENSMUST00000241520.2 Gm31616 ENSMUST00000241520.2 predicted gene, 31616, transcript variant 1 (from RefSeq NR_168582.1) ENSMUST00000241520.1 NR_168582 uc316juc.1 uc316juc.2 uc316juc.1 uc316juc.2 
ENSMUST00000241524.2 Gm56676 ENSMUST00000241524.2 Gm56676 (from geneSymbol) ENSMUST00000241524.1 uc316jug.1 uc316jug.2 uc316jug.1 uc316jug.2 
ENSMUST00000241534.2 Gm14808 ENSMUST00000241534.2 Gm14808 (from geneSymbol) ENSMUST00000241534.1 uc316juq.1 uc316juq.2 uc316juq.1 uc316juq.2 
ENSMUST00000241539.2 Gm56945 ENSMUST00000241539.2 Gm56945 (from geneSymbol) ENSMUST00000241539.1 LF198191 uc316juv.1 uc316juv.2 uc316juv.1 uc316juv.2 
ENSMUST00000241540.2 Gm56880 ENSMUST00000241540.2 Gm56880 (from geneSymbol) ENSMUST00000241540.1 uc316juw.1 uc316juw.2 uc316juw.1 uc316juw.2 
ENSMUST00000241543.2 Gm57236 ENSMUST00000241543.2 Gm57236 (from geneSymbol) ENSMUST00000241543.1 uc316juz.1 uc316juz.2 uc316juz.1 uc316juz.2 
ENSMUST00000241544.2 4732491K20Rik ENSMUST00000241544.2 4732491K20Rik (from geneSymbol) AK029100 ENSMUST00000241544.1 uc316jva.1 uc316jva.2 uc316jva.1 uc316jva.2 
ENSMUST00000241549.2 Gm56633 ENSMUST00000241549.2 Gm56633 (from geneSymbol) ENSMUST00000241549.1 uc316jvf.1 uc316jvf.2 uc316jvf.1 uc316jvf.2 
ENSMUST00000241554.1 Gm26644 ENSMUST00000241554.1 Gm26644 (from geneSymbol) uc316jvj.1 uc316jvj.1 
ENSMUST00000241564.2 Gm56696 ENSMUST00000241564.2 Gm56696 (from geneSymbol) ENSMUST00000241564.1 uc316jvt.1 uc316jvt.2 uc316jvt.1 uc316jvt.2 
ENSMUST00000241598.1 Gm56517 ENSMUST00000241598.1 Gm56517 (from geneSymbol) uc316jxb.1 uc316jxb.1 
ENSMUST00000241606.2 Gm57331 ENSMUST00000241606.2 Gm57331 (from geneSymbol) ENSMUST00000241606.1 uc316jxj.1 uc316jxj.2 uc316jxj.1 uc316jxj.2 
ENSMUST00000241607.2 2810036E18Rik ENSMUST00000241607.2 2810036E18Rik (from geneSymbol) AK012862 ENSMUST00000241607.1 uc316jxk.1 uc316jxk.2 uc316jxk.1 uc316jxk.2 
ENSMUST00000241611.2 A830009L08Rik ENSMUST00000241611.2 A830009L08Rik (from geneSymbol) AK043578 ENSMUST00000241611.1 uc316jxo.1 uc316jxo.2 uc316jxo.1 uc316jxo.2 
ENSMUST00000241614.2 4833411C07Rik ENSMUST00000241614.2 4833411C07Rik (from geneSymbol) AK050245 ENSMUST00000241614.1 uc316jxr.1 uc316jxr.2 uc316jxr.1 uc316jxr.2 
ENSMUST00000241616.2 Gm56816 ENSMUST00000241616.2 Gm56816 (from geneSymbol) ENSMUST00000241616.1 uc316jxt.1 uc316jxt.2 uc316jxt.1 uc316jxt.2 
ENSMUST00000241625.2 Gm56804 ENSMUST00000241625.2 Gm56804 (from geneSymbol) ENSMUST00000241625.1 uc316jyc.1 uc316jyc.2 uc316jyc.1 uc316jyc.2 
ENSMUST00000241631.2 Gm32655 ENSMUST00000241631.2 Gm32655 (from geneSymbol) ENSMUST00000241631.1 uc316jyi.1 uc316jyi.2 uc316jyi.1 uc316jyi.2 
ENSMUST00000241632.2 Gm33293 ENSMUST00000241632.2 predicted gene, 33293 (from RefSeq NR_169035.1) ENSMUST00000241632.1 NR_169035 uc316jyj.1 uc316jyj.2 uc316jyj.1 uc316jyj.2 
ENSMUST00000241655.1 Gm56561 ENSMUST00000241655.1 Gm56561 (from geneSymbol) uc316jzg.1 uc316jzg.1 
ENSMUST00000241674.2 Gm53533 ENSMUST00000241674.2 Gm53533 (from geneSymbol) ENSMUST00000241674.1 uc316jzz.1 uc316jzz.2 uc316jzz.1 uc316jzz.2 
ENSMUST00000241680.2 Gm56773 ENSMUST00000241680.2 Gm56773 (from geneSymbol) ENSMUST00000241680.1 uc316kaf.1 uc316kaf.2 uc316kaf.1 uc316kaf.2 
ENSMUST00000241695.1 Gm47682 ENSMUST00000241695.1 Gm47682 (from geneSymbol) uc316kau.1 uc316kau.1 
ENSMUST00000241709.2 Gm56799 ENSMUST00000241709.2 Gm56799 (from geneSymbol) ENSMUST00000241709.1 uc316kbh.1 uc316kbh.2 uc316kbh.1 uc316kbh.2 
ENSMUST00000241718.2 Gm56655 ENSMUST00000241718.2 Gm56655 (from geneSymbol) AK131841 ENSMUST00000241718.1 uc316kbp.1 uc316kbp.2 uc316kbp.1 uc316kbp.2 
ENSMUST00000241719.2 Gm57156 ENSMUST00000241719.2 Gm57156 (from geneSymbol) ENSMUST00000241719.1 uc316kbq.1 uc316kbq.2 uc316kbq.1 uc316kbq.2 
ENSMUST00000241745.2 Gm56911 ENSMUST00000241745.2 Gm56911 (from geneSymbol) ENSMUST00000241745.1 uc316kcq.1 uc316kcq.2 uc316kcq.1 uc316kcq.2 
ENSMUST00000241747.2 Gm30143 ENSMUST00000241747.2 Gm30143 (from geneSymbol) ENSMUST00000241747.1 uc316kcs.1 uc316kcs.2 uc316kcs.1 uc316kcs.2 
ENSMUST00000241776.2 Gm56852 ENSMUST00000241776.2 Gm56852 (from geneSymbol) ENSMUST00000241776.1 LF202809 uc316kdu.1 uc316kdu.2 uc316kdu.1 uc316kdu.2 
ENSMUST00000241797.2 Gm57376 ENSMUST00000241797.2 Gm57376 (from geneSymbol) ENSMUST00000241797.1 LF199016 uc316kep.1 uc316kep.2 uc316kep.1 uc316kep.2 
ENSMUST00000241802.1 Gm56693 ENSMUST00000241802.1 Gm56693 (from geneSymbol) uc316keu.1 uc316keu.1 
ENSMUST00000241803.2 Gm57378 ENSMUST00000241803.2 Gm57378 (from geneSymbol) ENSMUST00000241803.1 uc316kev.1 uc316kev.2 uc316kev.1 uc316kev.2 
ENSMUST00000241808.2 Gm54266 ENSMUST00000241808.2 Gm54266 (from geneSymbol) ENSMUST00000241808.1 uc316kez.1 uc316kez.2 uc316kez.1 uc316kez.2 
ENSMUST00000241811.2 Gm57073 ENSMUST00000241811.2 Gm57073 (from geneSymbol) ENSMUST00000241811.1 LF194527 uc316kfc.1 uc316kfc.2 uc316kfc.1 uc316kfc.2 
ENSMUST00000241812.2 Gm57332 ENSMUST00000241812.2 Gm57332 (from geneSymbol) ENSMUST00000241812.1 uc316kfd.1 uc316kfd.2 uc316kfd.1 uc316kfd.2 
ENSMUST00000241816.1 Gm57198 ENSMUST00000241816.1 Gm57198 (from geneSymbol) uc316kfg.1 uc316kfg.1 
ENSMUST00000241824.1 Gm33027 ENSMUST00000241824.1 Gm33027 (from geneSymbol) BC092221 uc316kfo.1 uc316kfo.1 
ENSMUST00000241835.2 Gm57367 ENSMUST00000241835.2 Gm57367 (from geneSymbol) AK045881 ENSMUST00000241835.1 uc316kfz.1 uc316kfz.2 uc316kfz.1 uc316kfz.2 
ENSMUST00000241839.2 I730030J21Rik ENSMUST00000241839.2 I730030J21Rik (from geneSymbol) ENSMUST00000241839.1 uc316kgd.1 uc316kgd.2 uc316kgd.1 uc316kgd.2 
ENSMUST00000241842.2 Gm57167 ENSMUST00000241842.2 Gm57167 (from geneSymbol) ENSMUST00000241842.1 uc316kgg.1 uc316kgg.2 uc316kgg.1 uc316kgg.2 
ENSMUST00000241851.2 Gm56643 ENSMUST00000241851.2 Gm56643 (from geneSymbol) ENSMUST00000241851.1 uc316kgp.1 uc316kgp.2 uc316kgp.1 uc316kgp.2 
ENSMUST00000241885.2 Gm34267 ENSMUST00000241885.2 Gm34267 (from geneSymbol) ENSMUST00000241885.1 uc316khx.1 uc316khx.2 uc316khx.1 uc316khx.2 
ENSMUST00000241886.2 Mir142hg ENSMUST00000241886.2 Mir142hg (from geneSymbol) ENSMUST00000241886.1 uc316khy.1 uc316khy.2 uc316khy.1 uc316khy.2 
ENSMUST00000241890.2 Gm56694 ENSMUST00000241890.2 Gm56694 (from geneSymbol) ENSMUST00000241890.1 uc316kic.1 uc316kic.2 uc316kic.1 uc316kic.2 
ENSMUST00000241891.2 Gm57411 ENSMUST00000241891.2 Gm57411 (from geneSymbol) ENSMUST00000241891.1 uc316kid.1 uc316kid.2 uc316kid.1 uc316kid.2 
ENSMUST00000241892.2 Gm40630 ENSMUST00000241892.2 Gm40630 (from geneSymbol) ENSMUST00000241892.1 uc316kie.1 uc316kie.2 uc316kie.1 uc316kie.2 
ENSMUST00000241894.2 1700102H20Rik ENSMUST00000241894.2 1700102H20Rik (from geneSymbol) AK015782 ENSMUST00000241894.1 uc316kig.1 uc316kig.2 uc316kig.1 uc316kig.2 
ENSMUST00000241896.1 Gm41469 ENSMUST00000241896.1 Gm41469 (from geneSymbol) uc316kii.1 uc316kii.1 
ENSMUST00000241899.2 Gm30938 ENSMUST00000241899.2 Gm30938 (from geneSymbol) ENSMUST00000241899.1 uc316kil.1 uc316kil.2 uc316kil.1 uc316kil.2 
ENSMUST00000241908.2 Gm57339 ENSMUST00000241908.2 Gm57339 (from geneSymbol) ENSMUST00000241908.1 uc316kiu.1 uc316kiu.2 uc316kiu.1 uc316kiu.2 
ENSMUST00000241934.2 Gm30925 ENSMUST00000241934.2 Gm30925 (from geneSymbol) ENSMUST00000241934.1 uc316kju.1 uc316kju.2 uc316kju.1 uc316kju.2 
ENSMUST00000241943.2 Gm57197 ENSMUST00000241943.2 Gm57197 (from geneSymbol) ENSMUST00000241943.1 uc316kkd.1 uc316kkd.2 uc316kkd.1 uc316kkd.2 
ENSMUST00000241953.2 Gm56637 ENSMUST00000241953.2 Gm56637 (from geneSymbol) AK043475 ENSMUST00000241953.1 uc316kkn.1 uc316kkn.2 uc316kkn.1 uc316kkn.2 
ENSMUST00000241954.2 Gm57024 ENSMUST00000241954.2 Gm57024 (from geneSymbol) ENSMUST00000241954.1 uc316kko.1 uc316kko.2 uc316kko.1 uc316kko.2 
ENSMUST00000241962.2 Gm56512 ENSMUST00000241962.2 Gm56512 (from geneSymbol) ENSMUST00000241962.1 uc316kkw.1 uc316kkw.2 uc316kkw.1 uc316kkw.2 
ENSMUST00000241976.2 Gm35117 ENSMUST00000241976.2 Gm35117 (from geneSymbol) ENSMUST00000241976.1 uc316klk.1 uc316klk.2 uc316klk.1 uc316klk.2 
ENSMUST00000241991.2 2610507I01Rik ENSMUST00000241991.2 2610507I01Rik (from geneSymbol) AK162965 ENSMUST00000241991.1 uc316kly.1 uc316kly.2 uc316kly.1 uc316kly.2 
ENSMUST00000241994.2 Gm57069 ENSMUST00000241994.2 Gm57069 (from geneSymbol) ENSMUST00000241994.1 LF194613 uc316kmb.1 uc316kmb.2 uc316kmb.1 uc316kmb.2 
ENSMUST00000241996.2 Gm12708 ENSMUST00000241996.2 Gm12708 (from geneSymbol) AK089375 ENSMUST00000241996.1 uc316kmd.1 uc316kmd.2 uc316kmd.1 uc316kmd.2 
ENSMUST00000242001.2 Gm56677 ENSMUST00000242001.2 Gm56677 (from geneSymbol) ENSMUST00000242001.1 uc316kmi.1 uc316kmi.2 uc316kmi.1 uc316kmi.2 
ENSMUST00000242003.2 Gm57386 ENSMUST00000242003.2 Gm57386 (from geneSymbol) ENSMUST00000242003.1 uc316kmk.1 uc316kmk.2 uc316kmk.1 uc316kmk.2 
ENSMUST00000242013.1 Six3os1 ENSMUST00000242013.1 Six3os1 (from geneSymbol) AY589789 uc316kmu.1 uc316kmu.1 
ENSMUST00000242016.2 Gm56595 ENSMUST00000242016.2 Gm56595 (from geneSymbol) ENSMUST00000242016.1 uc316kmx.1 uc316kmx.2 uc316kmx.1 uc316kmx.2 
ENSMUST00000242025.2 Gm42056 ENSMUST00000242025.2 Gm42056 (from geneSymbol) ENSMUST00000242025.1 uc316kng.1 uc316kng.2 uc316kng.1 uc316kng.2 
ENSMUST00000242051.2 Gm56695 ENSMUST00000242051.2 Gm56695 (from geneSymbol) ENSMUST00000242051.1 uc316kog.1 uc316kog.2 uc316kog.1 uc316kog.2 
ENSMUST00000242052.2 Gm30648 ENSMUST00000242052.2 Gm30648 (from geneSymbol) AK050464 ENSMUST00000242052.1 uc316koh.1 uc316koh.2 uc316koh.1 uc316koh.2 
ENSMUST00000242060.2 Gm56968 ENSMUST00000242060.2 Gm56968 (from geneSymbol) ENSMUST00000242060.1 uc316kop.1 uc316kop.2 uc316kop.1 uc316kop.2 
ENSMUST00000242064.2 Gm57315 ENSMUST00000242064.2 Gm57315 (from geneSymbol) ENSMUST00000242064.1 uc316kot.1 uc316kot.2 uc316kot.1 uc316kot.2 
ENSMUST00000242069.2 Gm56826 ENSMUST00000242069.2 Gm56826 (from geneSymbol) ENSMUST00000242069.1 uc316koy.1 uc316koy.2 uc316koy.1 uc316koy.2 
ENSMUST00000242072.2 Gm9895 ENSMUST00000242072.2 Gm9895 (from geneSymbol) AK028012 ENSMUST00000242072.1 uc316kpb.1 uc316kpb.2 uc316kpb.1 uc316kpb.2 
ENSMUST00000242074.1 Gm9744 ENSMUST00000242074.1 predicted gene 9744 (from RefSeq NR_188952.1) NR_188952 uc316kpd.1 uc316kpd.1 
ENSMUST00000242097.2 2010004M13Rik ENSMUST00000242097.2 RIKEN cDNA 2010004M13 gene (from RefSeq NR_190059.1) ENSMUST00000242097.1 NR_190059 uc316kpz.1 uc316kpz.2 uc316kpz.1 uc316kpz.2 
ENSMUST00000242103.2 Gm56678 ENSMUST00000242103.2 Gm56678 (from geneSymbol) ENSMUST00000242103.1 uc316kqf.1 uc316kqf.2 uc316kqf.1 uc316kqf.2 
ENSMUST00000242120.2 Gm56596 ENSMUST00000242120.2 Gm56596 (from geneSymbol) ENSMUST00000242120.1 uc316kqw.1 uc316kqw.2 uc316kqw.1 uc316kqw.2 
ENSMUST00000242123.2 E230013L22Rik ENSMUST00000242123.2 E230013L22Rik (from geneSymbol) AK054035 ENSMUST00000242123.1 uc316kqz.1 uc316kqz.2 uc316kqz.1 uc316kqz.2 
ENSMUST00000242134.2 Gm56894 ENSMUST00000242134.2 Gm56894 (from geneSymbol) ENSMUST00000242134.1 uc316krk.1 uc316krk.2 uc316krk.1 uc316krk.2 
ENSMUST00000242136.2 Gm57009 ENSMUST00000242136.2 Gm57009 (from geneSymbol) ENSMUST00000242136.1 LF197963 uc316krm.1 uc316krm.2 uc316krm.1 uc316krm.2 
ENSMUST00000242140.2 Gm56881 ENSMUST00000242140.2 Gm56881 (from geneSymbol) ENSMUST00000242140.1 uc316krq.1 uc316krq.2 uc316krq.1 uc316krq.2 
ENSMUST00000242190.1 Gm41032 ENSMUST00000242190.1 Gm41032 (from geneSymbol) uc316ktn.1 uc316ktn.1 
ENSMUST00000242195.2 Gm56928 ENSMUST00000242195.2 Gm56928 (from geneSymbol) ENSMUST00000242195.1 uc316kts.1 uc316kts.2 uc316kts.1 uc316kts.2 
ENSMUST00000242196.2 Gm35992 ENSMUST00000242196.2 Gm35992 (from geneSymbol) ENSMUST00000242196.1 uc316ktt.1 uc316ktt.2 uc316ktt.1 uc316ktt.2 
ENSMUST00000242198.2 Gm56929 ENSMUST00000242198.2 Gm56929 (from geneSymbol) ENSMUST00000242198.1 uc316ktv.1 uc316ktv.2 uc316ktv.1 uc316ktv.2 
ENSMUST00000242222.2 Gm56882 ENSMUST00000242222.2 Gm56882 (from geneSymbol) ENSMUST00000242222.1 uc316kus.1 uc316kus.2 uc316kus.1 uc316kus.2 
ENSMUST00000242259.2 Gm56887 ENSMUST00000242259.2 Gm56887 (from geneSymbol) ENSMUST00000242259.1 uc316kwd.1 uc316kwd.2 uc316kwd.1 uc316kwd.2 
ENSMUST00000242269.2 Gm57016 ENSMUST00000242269.2 Gm57016 (from geneSymbol) ENSMUST00000242269.1 uc316kwn.1 uc316kwn.2 uc316kwn.1 uc316kwn.2 
ENSMUST00000242294.2 Gm46828 ENSMUST00000242294.2 Gm46828 (from geneSymbol) ENSMUST00000242294.1 uc316kxm.1 uc316kxm.2 uc316kxm.1 uc316kxm.2 
ENSMUST00000242323.2 6820445E23Rik ENSMUST00000242323.2 6820445E23Rik (from geneSymbol) ENSMUST00000242323.1 LF198409 uc316kyp.1 uc316kyp.2 uc316kyp.1 uc316kyp.2 
ENSMUST00000242339.2 Gm47469 ENSMUST00000242339.2 Gm47469 (from geneSymbol) ENSMUST00000242339.1 uc316kzf.1 uc316kzf.2 uc316kzf.1 uc316kzf.2 
ENSMUST00000242343.2 Gm56959 ENSMUST00000242343.2 Gm56959 (from geneSymbol) AK018538 ENSMUST00000242343.1 uc316kzj.1 uc316kzj.2 uc316kzj.1 uc316kzj.2 
ENSMUST00000242344.2 Gm56777 ENSMUST00000242344.2 Gm56777 (from geneSymbol) ENSMUST00000242344.1 uc316kzk.1 uc316kzk.2 uc316kzk.1 uc316kzk.2 
ENSMUST00000242356.2 Gm56751 ENSMUST00000242356.2 Gm56751 (from geneSymbol) ENSMUST00000242356.1 uc316kzw.1 uc316kzw.2 uc316kzw.1 uc316kzw.2 
ENSMUST00000242429.1 4930500G05Rik ENSMUST00000242429.1 4930500G05Rik (from geneSymbol) AK015661 uc316lcr.1 uc316lcr.1 
ENSMUST00000242444.2 Gm57093 ENSMUST00000242444.2 Gm57093 (from geneSymbol) ENSMUST00000242444.1 uc316ldg.1 uc316ldg.2 uc316ldg.1 uc316ldg.2 
ENSMUST00000242462.1 Ly6a2 ENSMUST00000242462.1 Ly6a2 (from geneSymbol) AK152247 uc316ldy.1 uc316ldy.1 
ENSMUST00000242463.2 Gm56915 ENSMUST00000242463.2 Gm56915 (from geneSymbol) ENSMUST00000242463.1 uc316ldz.1 uc316ldz.2 uc316ldz.1 uc316ldz.2 
ENSMUST00000242469.1 Zfp33b ENSMUST00000242469.1 zinc finger protein 33B (from RefSeq NM_001424317.1) A0A9L6KDG1 A0A9L6KDG1_MOUSE NM_001424317 uc316lef.1 uc316lef.1 
ENSMUST00000242486.1 Gm57295 ENSMUST00000242486.1 Gm57295 (from geneSymbol) AK138792 uc316lev.1 uc316lev.1 
ENSMUST00000242500.2 5330434G04Rik ENSMUST00000242500.2 5330434G04Rik (from geneSymbol) AK163556 ENSMUST00000242500.1 uc316lfj.1 uc316lfj.2 uc316lfj.1 uc316lfj.2 
ENSMUST00000242506.2 Gm57455 ENSMUST00000242506.2 Gm57455 (from geneSymbol) ENSMUST00000242506.1 uc316lfp.1 uc316lfp.2 uc316lfp.1 uc316lfp.2 
ENSMUST00000242518.2 Gm57072 ENSMUST00000242518.2 Gm57072 (from geneSymbol) ENSMUST00000242518.1 uc316lga.1 uc316lga.2 uc316lga.1 uc316lga.2 
ENSMUST00000242548.2 Gm34703 ENSMUST00000242548.2 Gm34703 (from geneSymbol) ENSMUST00000242548.1 KY467707 uc316lhe.1 uc316lhe.2 uc316lhe.1 uc316lhe.2 
ENSMUST00000242556.2 Gm56650 ENSMUST00000242556.2 Gm56650 (from geneSymbol) ENSMUST00000242556.1 uc316lhm.1 uc316lhm.2 uc316lhm.1 uc316lhm.2 
ENSMUST00000242566.2 Gm43971 ENSMUST00000242566.2 Gm43971 (from geneSymbol) ENSMUST00000242566.1 uc316lhw.1 uc316lhw.2 uc316lhw.1 uc316lhw.2 
ENSMUST00000242573.2 Gm56883 ENSMUST00000242573.2 Gm56883 (from geneSymbol) ENSMUST00000242573.1 uc316lid.1 uc316lid.2 uc316lid.1 uc316lid.2 
ENSMUST00000242576.1 Gm29677 ENSMUST00000242576.1 Gm29677 (from geneSymbol) AK028463 uc316lig.1 uc316lig.1 
ENSMUST00000242586.2 Gm36587 ENSMUST00000242586.2 Gm36587 (from geneSymbol) ENSMUST00000242586.1 KY467761 uc316liq.1 uc316liq.2 uc316liq.1 uc316liq.2 
ENSMUST00000242599.2 Gm15848 ENSMUST00000242599.2 Gm15848 (from geneSymbol) ENSMUST00000242599.1 uc316ljd.1 uc316ljd.2 uc316ljd.1 uc316ljd.2 
ENSMUST00000242605.2 Gm57110 ENSMUST00000242605.2 Gm57110 (from geneSymbol) ENSMUST00000242605.1 uc316ljj.1 uc316ljj.2 uc316ljj.1 uc316ljj.2 
ENSMUST00000242615.2 A630066F11Rik ENSMUST00000242615.2 RIKEN cDNA A630066F11 gene (from RefSeq NR_030698.1) ENSMUST00000242615.1 NR_030698 uc316ljt.1 uc316ljt.2 uc316ljt.1 uc316ljt.2 
ENSMUST00000242629.2 Gm31785 ENSMUST00000242629.2 Gm31785 (from geneSymbol) ENSMUST00000242629.1 uc316lkh.1 uc316lkh.2 uc316lkh.1 uc316lkh.2 
ENSMUST00000242662.2 Gm24474 ENSMUST00000242662.2 Gm24474 (from geneSymbol) ENSMUST00000242662.1 uc316llo.1 uc316llo.2 uc316llo.1 uc316llo.2 
ENSMUST00000242665.2 A330069E16Rik ENSMUST00000242665.2 A330069E16Rik (from geneSymbol) BC042745 ENSMUST00000242665.1 uc316llr.1 uc316llr.2 uc316llr.1 uc316llr.2 
ENSMUST00000242670.1 Gm56513 ENSMUST00000242670.1 Gm56513 (from geneSymbol) uc316llw.1 uc316llw.1 
ENSMUST00000242675.2 Gm57287 ENSMUST00000242675.2 Gm57287 (from geneSymbol) ENSMUST00000242675.1 uc316lmb.1 uc316lmb.2 uc316lmb.1 uc316lmb.2 
ENSMUST00000242679.2 4930434J08Rik ENSMUST00000242679.2 RIKEN cDNA 4930434J08 gene (from RefSeq NR_168691.1) ENSMUST00000242679.1 NR_168691 uc316lmf.1 uc316lmf.2 uc316lmf.1 uc316lmf.2 
ENSMUST00000242682.2 Gm57297 ENSMUST00000242682.2 Gm57297 (from geneSymbol) ENSMUST00000242682.1 uc316lmi.1 uc316lmi.2 uc316lmi.1 uc316lmi.2 
ENSMUST00000242687.2 Gm57353 ENSMUST00000242687.2 Gm57353 (from geneSymbol) AK020381 ENSMUST00000242687.1 uc316lmn.1 uc316lmn.2 uc316lmn.1 uc316lmn.2 
ENSMUST00000242699.2 Gm56597 ENSMUST00000242699.2 Gm56597 (from geneSymbol) ENSMUST00000242699.1 uc316lmz.1 uc316lmz.2 uc316lmz.1 uc316lmz.2 
ENSMUST00000242701.2 Gm56848 ENSMUST00000242701.2 Gm56848 (from geneSymbol) ENSMUST00000242701.1 uc316lnb.1 uc316lnb.2 uc316lnb.1 uc316lnb.2 
ENSMUST00000242704.2 Gm56884 ENSMUST00000242704.2 Gm56884 (from geneSymbol) ENSMUST00000242704.1 uc316lne.1 uc316lne.2 uc316lne.1 uc316lne.2 
ENSMUST00000242770.2 Gm57271 ENSMUST00000242770.2 Gm57271 (from geneSymbol) ENSMUST00000242770.1 LF195182 uc316lps.1 uc316lps.2 uc316lps.1 uc316lps.2 
ENSMUST00000242775.2 Gm56786 ENSMUST00000242775.2 Gm56786 (from geneSymbol) ENSMUST00000242775.1 uc316lpx.1 uc316lpx.2 uc316lpx.1 uc316lpx.2 
ENSMUST00000242793.2 Gm44593 ENSMUST00000242793.2 Gm44593 (from geneSymbol) ENSMUST00000242793.1 uc316lqp.1 uc316lqp.2 uc316lqp.1 uc316lqp.2 
ENSMUST00000242803.2 5031425F14Rik ENSMUST00000242803.2 5031425F14Rik (from geneSymbol) AK040780 ENSMUST00000242803.1 uc316lqz.1 uc316lqz.2 uc316lqz.1 uc316lqz.2 
ENSMUST00000242805.2 Gm56814 ENSMUST00000242805.2 Gm56814 (from geneSymbol) ENSMUST00000242805.1 uc316lrb.1 uc316lrb.2 uc316lrb.1 uc316lrb.2 
ENSMUST00000242806.2 Gm57414 ENSMUST00000242806.2 Gm57414 (from geneSymbol) BC100606 ENSMUST00000242806.1 uc316lrc.1 uc316lrc.2 uc316lrc.1 uc316lrc.2 
ENSMUST00000242816.2 Gm57294 ENSMUST00000242816.2 Gm57294 (from geneSymbol) ENSMUST00000242816.1 uc316lrm.1 uc316lrm.2 uc316lrm.1 uc316lrm.2 
ENSMUST00000242821.2 Gm57263 ENSMUST00000242821.2 Gm57263 (from geneSymbol) ENSMUST00000242821.1 LF195133 uc316lrr.1 uc316lrr.2 uc316lrr.1 uc316lrr.2 
ENSMUST00000242830.2 Gm57338 ENSMUST00000242830.2 Gm57338 (from geneSymbol) ENSMUST00000242830.1 uc316lsa.1 uc316lsa.2 uc316lsa.1 uc316lsa.2 
ENSMUST00000242836.2 Gm57122 ENSMUST00000242836.2 Gm57122 (from geneSymbol) ENSMUST00000242836.1 uc316lsg.1 uc316lsg.2 uc316lsg.1 uc316lsg.2 
ENSMUST00000242837.2 Nlrp1c-ps ENSMUST00000242837.2 Nlrp1c-ps (from geneSymbol) DQ117602 ENSMUST00000242837.1 uc316lsh.1 uc316lsh.2 uc316lsh.1 uc316lsh.2 
ENSMUST00000242852.2 C230035I16Rik ENSMUST00000242852.2 C230035I16Rik (from geneSymbol) ENSMUST00000242852.1 KY467659 uc316lsw.1 uc316lsw.2 uc316lsw.1 uc316lsw.2 
ENSMUST00000242855.2 Gm56780 ENSMUST00000242855.2 Gm56780 (from geneSymbol) ENSMUST00000242855.1 uc316lsz.1 uc316lsz.2 uc316lsz.1 uc316lsz.2 
ENSMUST00000242862.2 Gm57307 ENSMUST00000242862.2 Gm57307 (from geneSymbol) AK046471 ENSMUST00000242862.1 uc316ltg.1 uc316ltg.2 uc316ltg.1 uc316ltg.2 
ENSMUST00000242863.2 A330094K24Rik ENSMUST00000242863.2 A330094K24Rik (from geneSymbol) AK020726 ENSMUST00000242863.1 uc316lth.1 uc316lth.2 uc316lth.1 uc316lth.2 
ENSMUST00000242879.2 Gm57196 ENSMUST00000242879.2 Gm57196 (from geneSymbol) ENSMUST00000242879.1 uc316ltx.1 uc316ltx.2 uc316ltx.1 uc316ltx.2 
ENSMUST00000242887.2 Gm56636 ENSMUST00000242887.2 Gm56636 (from geneSymbol) ENSMUST00000242887.1 LF201712 uc316luf.1 uc316luf.2 uc316luf.1 uc316luf.2 
ENSMUST00000242909.2 4930558N01Rik ENSMUST00000242909.2 4930558N01Rik (from geneSymbol) BC025039 ENSMUST00000242909.1 uc316lvb.1 uc316lvb.2 uc316lvb.1 uc316lvb.2 
ENSMUST00000242915.2 Gm57127 ENSMUST00000242915.2 Gm57127 (from geneSymbol) ENSMUST00000242915.1 uc316lvh.1 uc316lvh.2 uc316lvh.1 uc316lvh.2 
ENSMUST00000242941.2 A330102I10Rik ENSMUST00000242941.2 A330102I10Rik (from geneSymbol) AK020728 ENSMUST00000242941.1 uc316lwh.1 uc316lwh.2 uc316lwh.1 uc316lwh.2 
ENSMUST00000242966.2 C330008A17Rik ENSMUST00000242966.2 RIKEN cDNA C330008A17 gene, transcript variant 1 (from RefSeq NR_165175.1) ENSMUST00000242966.1 NR_165175 uc316lxg.1 uc316lxg.2 uc316lxg.1 uc316lxg.2 
ENSMUST00000242973.1 Gm46961 ENSMUST00000242973.1 Gm46961 (from geneSymbol) uc316lxn.1 uc316lxn.1 
ENSMUST00000242980.1 Gm57419 ENSMUST00000242980.1 Gm57419 (from geneSymbol) uc316lxu.1 uc316lxu.1 
ENSMUST00000242986.1 Gm56743 ENSMUST00000242986.1 Gm56743 (from geneSymbol) uc316lya.1 uc316lya.1 
ENSMUST00000242999.2 Gm31308 ENSMUST00000242999.2 predicted gene, 31308 (from RefSeq NR_175335.1) ENSMUST00000242999.1 NR_175335 uc316lyn.1 uc316lyn.2 uc316lyn.1 uc316lyn.2 
ENSMUST00000243006.2 Gm57437 ENSMUST00000243006.2 Gm57437 (from geneSymbol) ENSMUST00000243006.1 uc316lyu.1 uc316lyu.2 uc316lyu.1 uc316lyu.2 
ENSMUST00000243027.2 Gm56497 ENSMUST00000243027.2 Gm56497 (from geneSymbol) ENSMUST00000243027.1 uc316lzo.1 uc316lzo.2 uc316lzo.1 uc316lzo.2 
ENSMUST00000243034.2 2610035D17Rik ENSMUST00000243034.2 2610035D17Rik (from geneSymbol) AK031204 ENSMUST00000243034.1 uc316lzv.1 uc316lzv.2 uc316lzv.1 uc316lzv.2 
ENSMUST00000243066.1 Gm30624 ENSMUST00000243066.1 Gm30624 (from geneSymbol) uc316mbb.1 uc316mbb.1 
ENSMUST00000243069.2 E130119H09Rik ENSMUST00000243069.2 E130119H09Rik (from geneSymbol) AK021396 ENSMUST00000243069.1 uc316mbe.1 uc316mbe.2 uc316mbe.1 uc316mbe.2 
ENSMUST00000243079.2 2310016D03Rik ENSMUST00000243079.2 2310016D03Rik (from geneSymbol) AK009380 ENSMUST00000243079.1 uc316mbo.1 uc316mbo.2 uc316mbo.1 uc316mbo.2 
ENSMUST00000243089.2 Gm56705 ENSMUST00000243089.2 Gm56705 (from geneSymbol) AK207003 ENSMUST00000243089.1 uc316mby.1 uc316mby.2 uc316mby.1 uc316mby.2 
ENSMUST00000243101.2 Gm56886 ENSMUST00000243101.2 Gm56886 (from geneSymbol) ENSMUST00000243101.1 uc316mck.1 uc316mck.2 uc316mck.1 uc316mck.2 
ENSMUST00000243102.2 Gm12063 ENSMUST00000243102.2 Gm12063 (from geneSymbol) ENSMUST00000243102.1 uc316mcl.1 uc316mcl.2 uc316mcl.1 uc316mcl.2 
ENSMUST00000243113.1 2010309G21Rik ENSMUST00000243113.1 2010309G21Rik (from geneSymbol) uc316mcw.1 uc316mcw.1 
ENSMUST00000243115.2 Gm56781 ENSMUST00000243115.2 Gm56781 (from geneSymbol) ENSMUST00000243115.1 uc316mcy.1 uc316mcy.2 uc316mcy.1 uc316mcy.2 
ENSMUST00000243120.2 Gm9456 ENSMUST00000243120.2 predicted gene 9456 (from RefSeq NR_188730.1) ENSMUST00000243120.1 NR_188730 uc316mdd.1 uc316mdd.2 uc316mdd.1 uc316mdd.2 
ENSMUST00000243126.2 Gm56516 ENSMUST00000243126.2 Gm56516 (from geneSymbol) ENSMUST00000243126.1 uc316mdj.1 uc316mdj.2 uc316mdj.1 uc316mdj.2 
ENSMUST00000243145.1 Gm56519 ENSMUST00000243145.1 Gm56519 (from geneSymbol) uc316mec.1 uc316mec.1 
ENSMUST00000243148.2 Gm56699 ENSMUST00000243148.2 Gm56699 (from geneSymbol) ENSMUST00000243148.1 uc316mef.1 uc316mef.2 uc316mef.1 uc316mef.2 
ENSMUST00000243155.2 0610040B10Rik ENSMUST00000243155.2 0610040B10Rik (from geneSymbol) AK009603 ENSMUST00000243155.1 uc316mem.1 uc316mem.2 uc316mem.1 uc316mem.2 
ENSMUST00000243202.2 Gm57270 ENSMUST00000243202.2 Gm57270 (from geneSymbol) ENSMUST00000243202.1 uc316mgh.1 uc316mgh.2 uc316mgh.1 uc316mgh.2 
ENSMUST00000243219.1 Rmst ENSMUST00000243219.1 Rmst (from geneSymbol) AK086758 uc316mgy.1 uc316mgy.1 
ENSMUST00000243237.2 Ndufb4b ENSMUST00000243237.2 Ndufb4b (from geneSymbol) BC087907 ENSMUST00000243237.1 uc316mhq.1 uc316mhq.2 uc316mhq.1 uc316mhq.2 
ENSMUST00000243246.2 Gm19619 ENSMUST00000243246.2 Gm19619 (from geneSymbol) AK050091 ENSMUST00000243246.1 uc316mhz.1 uc316mhz.2 uc316mhz.1 uc316mhz.2 
ENSMUST00000243279.2 Gm56953 ENSMUST00000243279.2 Gm56953 (from geneSymbol) ENSMUST00000243279.1 uc316mjf.1 uc316mjf.2 uc316mjf.1 uc316mjf.2 
ENSMUST00000243280.2 Gm56600 ENSMUST00000243280.2 Gm56600 (from geneSymbol) ENSMUST00000243280.1 uc316mjg.1 uc316mjg.2 uc316mjg.1 uc316mjg.2 
ENSMUST00000243290.2 Gm57275 ENSMUST00000243290.2 Gm57275 (from geneSymbol) ENSMUST00000243290.1 LF195181 uc316mjq.1 uc316mjq.2 uc316mjq.1 uc316mjq.2 
ENSMUST00000243291.2 Gm31704 ENSMUST00000243291.2 predicted gene, 31704, transcript variant 1 (from RefSeq NR_166676.1) ENSMUST00000243291.1 NR_166676 uc316mjr.1 uc316mjr.2 uc316mjr.1 uc316mjr.2 
ENSMUST00000243299.2 Gm56954 ENSMUST00000243299.2 Gm56954 (from geneSymbol) ENSMUST00000243299.1 uc316mjz.1 uc316mjz.2 uc316mjz.1 uc316mjz.2 
ENSMUST00000243302.2 Gm56645 ENSMUST00000243302.2 Gm56645 (from geneSymbol) ENSMUST00000243302.1 uc316mkc.1 uc316mkc.2 uc316mkc.1 uc316mkc.2 
ENSMUST00000243303.2 Gm32673 ENSMUST00000243303.2 Gm32673 (from geneSymbol) ENSMUST00000243303.1 uc316mkd.1 uc316mkd.2 uc316mkd.1 uc316mkd.2 
ENSMUST00000243328.1 Gm5124 ENSMUST00000243328.1 Gm5124 (from geneSymbol) LF201930 uc316mlc.1 uc316mlc.1 
ENSMUST00000243332.2 Gm57341 ENSMUST00000243332.2 Gm57341 (from geneSymbol) AK155494 ENSMUST00000243332.1 uc316mlg.1 uc316mlg.2 uc316mlg.1 uc316mlg.2 
ENSMUST00000243349.2 Gm33152 ENSMUST00000243349.2 Gm33152 (from geneSymbol) ENSMUST00000243349.1 uc316mlw.1 uc316mlw.2 uc316mlw.1 uc316mlw.2 
ENSMUST00000243351.2 Gm56638 ENSMUST00000243351.2 Gm56638 (from geneSymbol) ENSMUST00000243351.1 uc316mly.1 uc316mly.2 uc316mly.1 uc316mly.2 
ENSMUST00000243355.2 5430431A17Rik ENSMUST00000243355.2 5430431A17Rik (from geneSymbol) AK017368 ENSMUST00000243355.1 uc316mmc.1 uc316mmc.2 uc316mmc.1 uc316mmc.2 
ENSMUST00000243357.2 Gm56640 ENSMUST00000243357.2 Gm56640 (from geneSymbol) ENSMUST00000243357.1 uc316mme.1 uc316mme.2 uc316mme.1 uc316mme.2 
ENSMUST00000243360.2 Gm17749 ENSMUST00000243360.2 Gm17749 (from geneSymbol) AK152566 ENSMUST00000243360.1 uc316mmh.1 uc316mmh.2 uc316mmh.1 uc316mmh.2 
ENSMUST00000243363.1 ENSMUSG00000121784 ENSMUST00000243363.1 ENSMUSG00000121784 (from geneSymbol) uc316mmk.1 uc316mmk.1 
ENSMUST00000243394.2 Snhg12 ENSMUST00000243394.2 Snhg12 (from geneSymbol) AK009175 ENSMUST00000243394.1 uc316mnp.1 uc316mnp.2 uc316mnp.1 uc316mnp.2 
ENSMUST00000243396.2 Gm57342 ENSMUST00000243396.2 Gm57342 (from geneSymbol) ENSMUST00000243396.1 uc316mnr.1 uc316mnr.2 uc316mnr.1 uc316mnr.2 
ENSMUST00000243404.2 Gm10824 ENSMUST00000243404.2 Gm10824 (from geneSymbol) AK033378 ENSMUST00000243404.1 uc316mnz.1 uc316mnz.2 uc316mnz.1 uc316mnz.2 
ENSMUST00000243420.2 1700080G18Rik ENSMUST00000243420.2 1700080G18Rik (from geneSymbol) AK006956 ENSMUST00000243420.1 uc316mop.1 uc316mop.2 uc316mop.1 uc316mop.2 
ENSMUST00000243428.2 Gm13594 ENSMUST00000243428.2 Gm13594 (from geneSymbol) AK007819 ENSMUST00000243428.1 uc316mox.1 uc316mox.2 uc316mox.1 uc316mox.2 
ENSMUST00000243437.2 Gm57343 ENSMUST00000243437.2 Gm57343 (from geneSymbol) ENSMUST00000243437.1 uc316mpg.1 uc316mpg.2 uc316mpg.1 uc316mpg.2 
ENSMUST00000243445.1 Gm43647 ENSMUST00000243445.1 Gm43647 (from geneSymbol) uc316mpo.1 uc316mpo.1 
ENSMUST00000243465.2 Gm56960 ENSMUST00000243465.2 Gm56960 (from geneSymbol) ENSMUST00000243465.1 uc316mqi.1 uc316mqi.2 uc316mqi.1 uc316mqi.2 
ENSMUST00000243479.1 Gm50136 ENSMUST00000243479.1 Gm50136 (from geneSymbol) uc316mqw.1 uc316mqw.1 
ENSMUST00000243490.1 Gm56602 ENSMUST00000243490.1 Gm56602 (from geneSymbol) AK146555 uc316mrh.1 uc316mrh.1 
ENSMUST00000243495.1 Gm57420 ENSMUST00000243495.1 Gm57420 (from geneSymbol) uc316mrm.1 uc316mrm.1 
ENSMUST00000243525.2 Gm57262 ENSMUST00000243525.2 Gm57262 (from geneSymbol) ENSMUST00000243525.1 uc316msq.1 uc316msq.2 uc316msq.1 uc316msq.2 
ENSMUST00000243549.2 Gm56603 ENSMUST00000243549.2 Gm56603 (from geneSymbol) ENSMUST00000243549.1 uc316mto.1 uc316mto.2 uc316mto.1 uc316mto.2 
ENSMUST00000243568.2 Gm57141 ENSMUST00000243568.2 Gm57141 (from geneSymbol) AK047056 ENSMUST00000243568.1 uc316muh.1 uc316muh.2 uc316muh.1 uc316muh.2 
ENSMUST00000243570.2 BB031773 ENSMUST00000243570.2 BB031773 (from geneSymbol) AK030945 ENSMUST00000243570.1 uc316muj.1 uc316muj.2 uc316muj.1 uc316muj.2 
ENSMUST00000243596.2 Gm56784 ENSMUST00000243596.2 Gm56784 (from geneSymbol) ENSMUST00000243596.1 uc316mvj.1 uc316mvj.2 uc316mvj.1 uc316mvj.2 
ENSMUST00000243599.2 Gm57345 ENSMUST00000243599.2 Gm57345 (from geneSymbol) ENSMUST00000243599.1 uc316mvm.1 uc316mvm.2 uc316mvm.1 uc316mvm.2 
ENSMUST00000243602.2 Gm56568 ENSMUST00000243602.2 Gm56568 (from geneSymbol) AK050188 ENSMUST00000243602.1 uc316mvp.1 uc316mvp.2 uc316mvp.1 uc316mvp.2 
ENSMUST00000243618.2 Gm57264 ENSMUST00000243618.2 Gm57264 (from geneSymbol) ENSMUST00000243618.1 uc316mwf.1 uc316mwf.2 uc316mwf.1 uc316mwf.2 
ENSMUST00000243627.1 Gm35340 ENSMUST00000243627.1 Gm35340 (from geneSymbol) uc316mwo.1 uc316mwo.1 
ENSMUST00000243644.2 Gm57346 ENSMUST00000243644.2 Gm57346 (from geneSymbol) ENSMUST00000243644.1 uc316mxf.1 uc316mxf.2 uc316mxf.1 uc316mxf.2 
ENSMUST00000243648.2 4930568A12Rik ENSMUST00000243648.2 4930568A12Rik (from geneSymbol) AK016244 ENSMUST00000243648.1 uc316mxi.1 uc316mxi.2 uc316mxi.1 uc316mxi.2 
ENSMUST00000243678.2 Gm57086 ENSMUST00000243678.2 Gm57086 (from geneSymbol) ENSMUST00000243678.1 uc316myl.1 uc316myl.2 uc316myl.1 uc316myl.2 
ENSMUST00000243688.2 Gm56753 ENSMUST00000243688.2 Gm56753 (from geneSymbol) ENSMUST00000243688.1 uc316myv.1 uc316myv.2 uc316myv.1 uc316myv.2 
ENSMUST00000243707.2 Gm57059 ENSMUST00000243707.2 Gm57059 (from geneSymbol) ENSMUST00000243707.1 uc316mzn.1 uc316mzn.2 uc316mzn.1 uc316mzn.2 
ENSMUST00000243713.1 Gm56701 ENSMUST00000243713.1 Gm56701 (from geneSymbol) uc316mzt.1 uc316mzt.1 
ENSMUST00000243738.2 Gm30211 ENSMUST00000243738.2 Gm30211 (from geneSymbol) AK036494 ENSMUST00000243738.1 uc316nas.1 uc316nas.2 uc316nas.1 uc316nas.2 
ENSMUST00000243748.2 Gm38875 ENSMUST00000243748.2 Gm38875 (from geneSymbol) ENSMUST00000243748.1 uc316nbc.1 uc316nbc.2 uc316nbc.1 uc316nbc.2 
ENSMUST00000243780.2 Gm57204 ENSMUST00000243780.2 Gm57204 (from geneSymbol) ENSMUST00000243780.1 KY468155 uc316nci.1 uc316nci.2 uc316nci.1 uc316nci.2 
ENSMUST00000243819.2 Gm56679 ENSMUST00000243819.2 Gm56679 (from geneSymbol) ENSMUST00000243819.1 uc316ndv.1 uc316ndv.2 uc316ndv.1 uc316ndv.2 
ENSMUST00000243828.2 Gm57347 ENSMUST00000243828.2 Gm57347 (from geneSymbol) ENSMUST00000243828.1 uc316nee.1 uc316nee.2 uc316nee.1 uc316nee.2 
ENSMUST00000243841.2 Gm56520 ENSMUST00000243841.2 Gm56520 (from geneSymbol) ENSMUST00000243841.1 uc316ner.1 uc316ner.2 uc316ner.1 uc316ner.2 
ENSMUST00000243868.1 Gm35268 ENSMUST00000243868.1 Gm35268 (from geneSymbol) uc316nfs.1 uc316nfs.1 
ENSMUST00000243905.2 Gm56605 ENSMUST00000243905.2 Gm56605 (from geneSymbol) ENSMUST00000243905.1 uc316nhc.1 uc316nhc.2 uc316nhc.1 uc316nhc.2 
ENSMUST00000243924.2 Gm56702 ENSMUST00000243924.2 Gm56702 (from geneSymbol) ENSMUST00000243924.1 uc316nhv.1 uc316nhv.2 uc316nhv.1 uc316nhv.2 
ENSMUST00000243930.2 Gm56712 ENSMUST00000243930.2 Gm56712 (from geneSymbol) ENSMUST00000243930.1 uc316nib.1 uc316nib.2 uc316nib.1 uc316nib.2 
ENSMUST00000243931.1 Gm56607 ENSMUST00000243931.1 Gm56607 (from geneSymbol) uc316nic.1 uc316nic.1 
ENSMUST00000243963.2 Gm56946 ENSMUST00000243963.2 Gm56946 (from geneSymbol) ENSMUST00000243963.1 uc316njg.1 uc316njg.2 uc316njg.1 uc316njg.2 
ENSMUST00000243988.2 Gm56755 ENSMUST00000243988.2 Gm56755 (from geneSymbol) AK084066 ENSMUST00000243988.1 uc316nke.1 uc316nke.2 uc316nke.1 uc316nke.2 
ENSMUST00000243995.2 Gm56744 ENSMUST00000243995.2 Gm56744 (from geneSymbol) ENSMUST00000243995.1 uc316nkl.1 uc316nkl.2 uc316nkl.1 uc316nkl.2 
ENSMUST00000243997.2 Gm57080 ENSMUST00000243997.2 Gm57080 (from geneSymbol) ENSMUST00000243997.1 uc316nkn.1 uc316nkn.2 uc316nkn.1 uc316nkn.2 
ENSMUST00000244009.2 Gm57018 ENSMUST00000244009.2 Gm57018 (from geneSymbol) ENSMUST00000244009.1 uc316nkz.1 uc316nkz.2 uc316nkz.1 uc316nkz.2 
ENSMUST00000244014.2 Gm30421 ENSMUST00000244014.2 Gm30421 (from geneSymbol) ENSMUST00000244014.1 uc316nle.1 uc316nle.2 uc316nle.1 uc316nle.2 
ENSMUST00000244042.2 Gm56499 ENSMUST00000244042.2 Gm56499 (from geneSymbol) ENSMUST00000244042.1 uc316nmf.1 uc316nmf.2 uc316nmf.1 uc316nmf.2 
ENSMUST00000244046.2 Gm56715 ENSMUST00000244046.2 Gm56715 (from geneSymbol) ENSMUST00000244046.1 uc316nmj.1 uc316nmj.2 uc316nmj.1 uc316nmj.2 
ENSMUST00000244057.1 Dlx6os1 ENSMUST00000244057.1 Dlx6os1 (from geneSymbol) AK032537 uc316nmu.1 uc316nmu.1 
ENSMUST00000244059.1 Gm56500 ENSMUST00000244059.1 Gm56500 (from geneSymbol) uc316nmw.1 uc316nmw.1 
ENSMUST00000244065.2 Gm57118 ENSMUST00000244065.2 Gm57118 (from geneSymbol) ENSMUST00000244065.1 uc316nnc.1 uc316nnc.2 uc316nnc.1 uc316nnc.2 
ENSMUST00000244089.2 Gm56888 ENSMUST00000244089.2 Gm56888 (from geneSymbol) ENSMUST00000244089.1 uc316nnz.1 uc316nnz.2 uc316nnz.1 uc316nnz.2 
ENSMUST00000244099.1 Gm57081 ENSMUST00000244099.1 Gm57081 (from geneSymbol) uc316noi.1 uc316noi.1 
ENSMUST00000244105.2 Gm57267 ENSMUST00000244105.2 Gm57267 (from geneSymbol) ENSMUST00000244105.1 uc316noo.1 uc316noo.2 uc316noo.1 uc316noo.2 
ENSMUST00000244106.2 Gm57082 ENSMUST00000244106.2 Gm57082 (from geneSymbol) ENSMUST00000244106.1 uc316nop.1 uc316nop.2 uc316nop.1 uc316nop.2 
ENSMUST00000244118.1 Gm56572 ENSMUST00000244118.1 Gm56572 (from geneSymbol) LF203976 uc316npb.1 uc316npb.1 
ENSMUST00000244123.1 Zfp939 ENSMUST00000244123.1 zinc finger protein 939, transcript variant 2 (from RefSeq NR_157256.1) NR_157256 uc316npg.1 uc316npg.1 
ENSMUST00000244128.2 Gm15608 ENSMUST00000244128.2 Gm15608 (from geneSymbol) ENSMUST00000244128.1 uc316npl.1 uc316npl.2 uc316npl.1 uc316npl.2 
ENSMUST00000244136.1 Gm56522 ENSMUST00000244136.1 Gm56522 (from geneSymbol) uc316npt.1 uc316npt.1 
ENSMUST00000244140.2 Gm11335 ENSMUST00000244140.2 predicted gene 11335, transcript variant 2 (from RefSeq NR_167693.1) ENSMUST00000244140.1 NR_167693 uc316npx.1 uc316npx.2 uc316npx.1 uc316npx.2 
ENSMUST00000244149.2 Gm56961 ENSMUST00000244149.2 Gm56961 (from geneSymbol) ENSMUST00000244149.1 uc316nqg.1 uc316nqg.2 uc316nqg.1 uc316nqg.2 
ENSMUST00000244156.2 Gm39035 ENSMUST00000244156.2 Gm39035 (from geneSymbol) ENSMUST00000244156.1 uc316nqn.1 uc316nqn.2 uc316nqn.1 uc316nqn.2 
ENSMUST00000244161.2 Gm57381 ENSMUST00000244161.2 Gm57381 (from geneSymbol) ENSMUST00000244161.1 uc316nqs.1 uc316nqs.2 uc316nqs.1 uc316nqs.2 
ENSMUST00000244173.2 Gm56612 ENSMUST00000244173.2 Gm56612 (from geneSymbol) ENSMUST00000244173.1 uc316nre.1 uc316nre.2 uc316nre.1 uc316nre.2 
ENSMUST00000244175.1 Gm57423 ENSMUST00000244175.1 Gm57423 (from geneSymbol) uc316nrg.1 uc316nrg.1 
ENSMUST00000244177.2 Gm56704 ENSMUST00000244177.2 Gm56704 (from geneSymbol) ENSMUST00000244177.1 uc316nri.1 uc316nri.2 uc316nri.1 uc316nri.2 
ENSMUST00000244181.1 Gm56649 ENSMUST00000244181.1 Gm56649 (from geneSymbol) uc316nrl.1 uc316nrl.1 
ENSMUST00000244197.2 4921520J07Rik ENSMUST00000244197.2 4921520J07Rik (from geneSymbol) AK014930 ENSMUST00000244197.1 uc316nsb.1 uc316nsb.2 uc316nsb.1 uc316nsb.2 
ENSMUST00000244211.2 Gm57091 ENSMUST00000244211.2 Gm57091 (from geneSymbol) ENSMUST00000244211.1 uc316nsp.1 uc316nsp.2 uc316nsp.1 uc316nsp.2 
ENSMUST00000244220.2 Gm57083 ENSMUST00000244220.2 Gm57083 (from geneSymbol) ENSMUST00000244220.1 uc316nsy.1 uc316nsy.2 uc316nsy.1 uc316nsy.2 
ENSMUST00000244239.1 2810429I04Rik ENSMUST00000244239.1 2810429I04Rik (from geneSymbol) AK031301 uc316ntq.1 uc316ntq.1 
ENSMUST00000244251.2 Gm56616 ENSMUST00000244251.2 Gm56616 (from geneSymbol) BC049692 ENSMUST00000244251.1 uc316nuc.1 uc316nuc.2 uc316nuc.1 uc316nuc.2 
ENSMUST00000244260.2 Gm56556 ENSMUST00000244260.2 Gm56556 (from geneSymbol) ENSMUST00000244260.1 uc316nul.1 uc316nul.2 uc316nul.1 uc316nul.2 
ENSMUST00000244264.2 Gm57291 ENSMUST00000244264.2 Gm57291 (from geneSymbol) ENSMUST00000244264.1 uc316nup.1 uc316nup.2 uc316nup.1 uc316nup.2 
ENSMUST00000244272.2 Gm56864 ENSMUST00000244272.2 Gm56864 (from geneSymbol) ENSMUST00000244272.1 uc316nux.1 uc316nux.2 uc316nux.1 uc316nux.2 
ENSMUST00000244278.2 Gm57444 ENSMUST00000244278.2 Gm57444 (from geneSymbol) ENSMUST00000244278.1 uc316nvd.1 uc316nvd.2 uc316nvd.1 uc316nvd.2 
ENSMUST00000244290.1 Lncenc1 ENSMUST00000244290.1 Lncenc1 (from geneSymbol) BC065997 uc316nvp.1 uc316nvp.1 
ENSMUST00000244294.1 Gm32611 ENSMUST00000244294.1 Gm32611 (from geneSymbol) uc316nvt.1 uc316nvt.1 
ENSMUST00000244305.2 Gm35164 ENSMUST00000244305.2 Gm35164 (from geneSymbol) ENSMUST00000244305.1 uc316nwe.1 uc316nwe.2 uc316nwe.1 uc316nwe.2 
ENSMUST00000244306.2 Gm56526 ENSMUST00000244306.2 Gm56526 (from geneSymbol) ENSMUST00000244306.1 uc316nwf.1 uc316nwf.2 uc316nwf.1 uc316nwf.2 
ENSMUST00000244329.2 Thap6 ENSMUST00000244329.2 Thap6 (from geneSymbol) BC089377 ENSMUST00000244329.1 uc316nxc.1 uc316nxc.2 uc316nxc.1 uc316nxc.2 
ENSMUST00000244335.2 A330048O09Rik ENSMUST00000244335.2 A330048O09Rik (from geneSymbol) AK079799 ENSMUST00000244335.1 uc316nxi.1 uc316nxi.2 uc316nxi.1 uc316nxi.2 
ENSMUST00000244337.2 Gm31504 ENSMUST00000244337.2 Gm31504 (from geneSymbol) ENSMUST00000244337.1 uc316nxk.1 uc316nxk.2 uc316nxk.1 uc316nxk.2 
ENSMUST00000244338.2 Gm56501 ENSMUST00000244338.2 Gm56501 (from geneSymbol) ENSMUST00000244338.1 uc316nxl.1 uc316nxl.2 uc316nxl.1 uc316nxl.2 
ENSMUST00000244354.2 Gm32391 ENSMUST00000244354.2 Gm32391 (from geneSymbol) ENSMUST00000244354.1 uc316nyb.1 uc316nyb.2 uc316nyb.1 uc316nyb.2 
ENSMUST00000244357.2 9630028I04Rik ENSMUST00000244357.2 9630028I04Rik (from geneSymbol) AK036033 ENSMUST00000244357.1 uc316nye.1 uc316nye.2 uc316nye.1 uc316nye.2 
ENSMUST00000244365.2 Gm56831 ENSMUST00000244365.2 Gm56831 (from geneSymbol) ENSMUST00000244365.1 uc316nym.1 uc316nym.2 uc316nym.1 uc316nym.2 
ENSMUST00000244366.2 Gm56787 ENSMUST00000244366.2 Gm56787 (from geneSymbol) ENSMUST00000244366.1 uc316nyn.1 uc316nyn.2 uc316nyn.1 uc316nyn.2 
ENSMUST00000244382.2 Gm56803 ENSMUST00000244382.2 Gm56803 (from geneSymbol) ENSMUST00000244382.1 uc316nzd.1 uc316nzd.2 uc316nzd.1 uc316nzd.2 
ENSMUST00000244383.2 Gm57205 ENSMUST00000244383.2 Gm57205 (from geneSymbol) ENSMUST00000244383.1 uc316nze.1 uc316nze.2 uc316nze.1 uc316nze.2 
ENSMUST00000244391.2 Gm8883 ENSMUST00000244391.2 Gm8883 (from geneSymbol) ENSMUST00000244391.1 uc316nzm.1 uc316nzm.2 uc316nzm.1 uc316nzm.2 
ENSMUST00000244405.2 Gm56651 ENSMUST00000244405.2 Gm56651 (from geneSymbol) ENSMUST00000244405.1 uc316oaa.1 uc316oaa.2 uc316oaa.1 uc316oaa.2 
ENSMUST00000244427.2 Gm20513 ENSMUST00000244427.2 Gm20513 (from geneSymbol) AK153671 ENSMUST00000244427.1 uc316oaw.1 uc316oaw.2 uc316oaw.1 uc316oaw.2 
ENSMUST00000244437.2 Gm56549 ENSMUST00000244437.2 Gm56549 (from geneSymbol) ENSMUST00000244437.1 uc316obg.1 uc316obg.2 uc316obg.1 uc316obg.2 
ENSMUST00000244456.1 4933424M12Rik ENSMUST00000244456.1 4933424M12Rik (from geneSymbol) AK016899 uc316oby.1 uc316oby.1 
ENSMUST00000244461.2 Gm56528 ENSMUST00000244461.2 Gm56528 (from geneSymbol) ENSMUST00000244461.1 uc316ocd.1 uc316ocd.2 uc316ocd.1 uc316ocd.2 
ENSMUST00000244475.2 Gm57088 ENSMUST00000244475.2 Gm57088 (from geneSymbol) ENSMUST00000244475.1 uc316ocp.1 uc316ocp.2 uc316ocp.1 uc316ocp.2 
ENSMUST00000244478.2 Gm57089 ENSMUST00000244478.2 Gm57089 (from geneSymbol) ENSMUST00000244478.1 uc316ocs.1 uc316ocs.2 uc316ocs.1 uc316ocs.2 
ENSMUST00000244496.2 C030013E06Rik ENSMUST00000244496.2 C030013E06Rik (from geneSymbol) ENSMUST00000244496.1 uc316odk.1 uc316odk.2 uc316odk.1 uc316odk.2 
ENSMUST00000244526.2 Gm56756 ENSMUST00000244526.2 Gm56756 (from geneSymbol) AK032087 ENSMUST00000244526.1 uc316oeo.1 uc316oeo.2 uc316oeo.1 uc316oeo.2 
ENSMUST00000244528.2 Gm35071 ENSMUST00000244528.2 Gm35071 (from geneSymbol) ENSMUST00000244528.1 uc316oeq.1 uc316oeq.2 uc316oeq.1 uc316oeq.2 
ENSMUST00000244552.2 C920006O11Rik ENSMUST00000244552.2 C920006O11Rik (from geneSymbol) AK050586 ENSMUST00000244552.1 uc316ofo.1 uc316ofo.2 uc316ofo.1 uc316ofo.2 
ENSMUST00000244567.1 A530072M11Rik ENSMUST00000244567.1 A530072M11Rik (from geneSymbol) AK080160 uc316ogb.1 uc316ogb.1 
ENSMUST00000244591.2 Gm53681 ENSMUST00000244591.2 Gm53681 (from geneSymbol) ENSMUST00000244591.1 uc316ogz.1 uc316ogz.2 uc316ogz.1 uc316ogz.2 
ENSMUST00000244592.1 5730420D15Rik ENSMUST00000244592.1 5730420D15Rik (from geneSymbol) AK017586 uc316oha.1 uc316oha.1 
ENSMUST00000244600.2 Gm56502 ENSMUST00000244600.2 Gm56502 (from geneSymbol) ENSMUST00000244600.1 uc316ohi.1 uc316ohi.2 uc316ohi.1 uc316ohi.2 
ENSMUST00000244606.1 Gm11728 ENSMUST00000244606.1 Gm11728 (from geneSymbol) AK136642 uc316oho.1 uc316oho.1 
ENSMUST00000244614.2 Gm56851 ENSMUST00000244614.2 Gm56851 (from geneSymbol) ENSMUST00000244614.1 MF573324 uc316ohw.1 uc316ohw.2 uc316ohw.1 uc316ohw.2 
ENSMUST00000244634.2 Gm57274 ENSMUST00000244634.2 Gm57274 (from geneSymbol) ENSMUST00000244634.1 uc316oip.1 uc316oip.2 uc316oip.1 uc316oip.2 
ENSMUST00000244635.2 Gm56720 ENSMUST00000244635.2 Gm56720 (from geneSymbol) ENSMUST00000244635.1 uc316oiq.1 uc316oiq.2 uc316oiq.1 uc316oiq.2 
ENSMUST00000244647.2 Gm57425 ENSMUST00000244647.2 Gm57425 (from geneSymbol) ENSMUST00000244647.1 uc316ojc.1 uc316ojc.2 uc316ojc.1 uc316ojc.2 
ENSMUST00000244652.2 Gm34331 ENSMUST00000244652.2 Gm34331 (from geneSymbol) ENSMUST00000244652.1 uc316ojh.1 uc316ojh.2 uc316ojh.1 uc316ojh.2 
ENSMUST00000244657.2 Gm29483 ENSMUST00000244657.2 predicted gene 29483 (from RefSeq NR_166120.1) ENSMUST00000244657.1 NR_166120 uc316ojm.1 uc316ojm.2 uc316ojm.1 uc316ojm.2 
ENSMUST00000244662.2 Gm57090 ENSMUST00000244662.2 Gm57090 (from geneSymbol) ENSMUST00000244662.1 uc316ojr.1 uc316ojr.2 uc316ojr.1 uc316ojr.2 
ENSMUST00000244667.2 Gm56503 ENSMUST00000244667.2 Gm56503 (from geneSymbol) ENSMUST00000244667.1 uc316ojw.1 uc316ojw.2 uc316ojw.1 uc316ojw.2 
ENSMUST00000244680.2 Gm56653 ENSMUST00000244680.2 Gm56653 (from geneSymbol) ENSMUST00000244680.1 uc316okj.1 uc316okj.2 uc316okj.1 uc316okj.2 
ENSMUST00000244682.2 Gm56550 ENSMUST00000244682.2 Gm56550 (from geneSymbol) ENSMUST00000244682.1 uc316okl.1 uc316okl.2 uc316okl.1 uc316okl.2 
ENSMUST00000244693.2 Gm57276 ENSMUST00000244693.2 Gm57276 (from geneSymbol) ENSMUST00000244693.1 uc316okw.1 uc316okw.2 uc316okw.1 uc316okw.2 
ENSMUST00000244696.2 Gm56575 ENSMUST00000244696.2 Gm56575 (from geneSymbol) ENSMUST00000244696.1 uc316okz.1 uc316okz.2 uc316okz.1 uc316okz.2 
ENSMUST00000244708.2 Gm56815 ENSMUST00000244708.2 Gm56815 (from geneSymbol) ENSMUST00000244708.1 uc316oll.1 uc316oll.2 uc316oll.1 uc316oll.2 
ENSMUST00000244711.2 Gm57092 ENSMUST00000244711.2 Gm57092 (from geneSymbol) ENSMUST00000244711.1 uc316olo.1 uc316olo.2 uc316olo.1 uc316olo.2 
ENSMUST00000244716.2 Gm57460 ENSMUST00000244716.2 Gm57460 (from geneSymbol) ENSMUST00000244716.1 uc316olt.1 uc316olt.2 uc316olt.1 uc316olt.2 
ENSMUST00000244719.2 Gm56868 ENSMUST00000244719.2 Gm56868 (from geneSymbol) AK141163 ENSMUST00000244719.1 uc316olw.1 uc316olw.2 uc316olw.1 uc316olw.2 
ENSMUST00000244722.2 Gm12295 ENSMUST00000244722.2 Gm12295 (from geneSymbol) AK042647 ENSMUST00000244722.1 uc316olz.1 uc316olz.2 uc316olz.1 uc316olz.2 
ENSMUST00000244733.2 Gm56611 ENSMUST00000244733.2 Gm56611 (from geneSymbol) ENSMUST00000244733.1 uc316omk.1 uc316omk.2 uc316omk.1 uc316omk.2 
ENSMUST00000244744.2 Gm30866 ENSMUST00000244744.2 Gm30866 (from geneSymbol) ENSMUST00000244744.1 uc316omv.1 uc316omv.2 uc316omv.1 uc316omv.2 
ENSMUST00000244766.2 Gm56857 ENSMUST00000244766.2 Gm56857 (from geneSymbol) ENSMUST00000244766.1 LF196940 uc316onr.1 uc316onr.2 uc316onr.1 uc316onr.2 
ENSMUST00000244776.1 Gm56508 ENSMUST00000244776.1 Gm56508 (from geneSymbol) uc316oob.1 uc316oob.1 
ENSMUST00000244779.2 Gm56970 ENSMUST00000244779.2 Gm56970 (from geneSymbol) ENSMUST00000244779.1 LF198243 uc316ooe.1 uc316ooe.2 uc316ooe.1 uc316ooe.2 
ENSMUST00000244785.2 Gm54030 ENSMUST00000244785.2 Gm54030 (from geneSymbol) ENSMUST00000244785.1 uc316ook.1 uc316ook.2 uc316ook.1 uc316ook.2 
ENSMUST00000244803.1 Gm56504 ENSMUST00000244803.1 Gm56504 (from geneSymbol) uc316opc.1 uc316opc.1 
ENSMUST00000244810.2 Gm56732 ENSMUST00000244810.2 Gm56732 (from geneSymbol) ENSMUST00000244810.1 uc316opi.1 uc316opi.2 uc316opi.1 uc316opi.2 
ENSMUST00000244827.2 Gm56789 ENSMUST00000244827.2 Gm56789 (from geneSymbol) ENSMUST00000244827.1 uc316opz.1 uc316opz.2 uc316opz.1 uc316opz.2 
ENSMUST00000244840.2 Gm29688 ENSMUST00000244840.2 Gm29688 (from geneSymbol) BC094642 ENSMUST00000244840.1 uc316oqm.1 uc316oqm.2 uc316oqm.1 uc316oqm.2 
ENSMUST00000244848.2 Gm56934 ENSMUST00000244848.2 Gm56934 (from geneSymbol) ENSMUST00000244848.1 uc316oqu.1 uc316oqu.2 uc316oqu.1 uc316oqu.2 
ENSMUST00000244861.2 Gm39114 ENSMUST00000244861.2 Gm39114 (from geneSymbol) ENSMUST00000244861.1 uc316org.1 uc316org.2 uc316org.1 uc316org.2 
ENSMUST00000244890.1 Gm56609 ENSMUST00000244890.1 Gm56609 (from geneSymbol) uc316osj.1 uc316osj.1 
ENSMUST00000244912.2 Gm57427 ENSMUST00000244912.2 Gm57427 (from geneSymbol) ENSMUST00000244912.1 uc316otf.1 uc316otf.2 uc316otf.1 uc316otf.2 
ENSMUST00000244937.2 Gm57113 ENSMUST00000244937.2 Gm57113 (from geneSymbol) ENSMUST00000244937.1 LF242402 uc316oue.1 uc316oue.2 uc316oue.1 uc316oue.2 
ENSMUST00000244940.2 Gm57019 ENSMUST00000244940.2 Gm57019 (from geneSymbol) ENSMUST00000244940.1 uc316ouh.1 uc316ouh.2 uc316ouh.1 uc316ouh.2 
ENSMUST00000244947.2 Gm57430 ENSMUST00000244947.2 Gm57430 (from geneSymbol) ENSMUST00000244947.1 uc316ouo.1 uc316ouo.2 uc316ouo.1 uc316ouo.2 
ENSMUST00000244959.2 1810019D21Rik ENSMUST00000244959.2 1810019D21Rik (from geneSymbol) AK007545 ENSMUST00000244959.1 uc316ova.1 uc316ova.2 uc316ova.1 uc316ova.2 
ENSMUST00000244962.2 Gm56983 ENSMUST00000244962.2 Gm56983 (from geneSymbol) ENSMUST00000244962.1 uc316ovd.1 uc316ovd.2 uc316ovd.1 uc316ovd.2 
ENSMUST00000244967.2 Gm35049 ENSMUST00000244967.2 Gm35049 (from geneSymbol) ENSMUST00000244967.1 uc316ovi.1 uc316ovi.2 uc316ovi.1 uc316ovi.2 
ENSMUST00000244969.2 Gm20319 ENSMUST00000244969.2 Gm20319 (from geneSymbol) AK050069 ENSMUST00000244969.1 uc316ovk.1 uc316ovk.2 uc316ovk.1 uc316ovk.2 
ENSMUST00000244996.2 Gm57102 ENSMUST00000244996.2 Gm57102 (from geneSymbol) ENSMUST00000244996.1 uc316owk.1 uc316owk.2 uc316owk.1 uc316owk.2 
ENSMUST00000244998.2 Gm57279 ENSMUST00000244998.2 Gm57279 (from geneSymbol) ENSMUST00000244998.1 uc316owm.1 uc316owm.2 uc316owm.1 uc316owm.2 
ENSMUST00000245000.2 Gm56688 ENSMUST00000245000.2 Gm56688 (from geneSymbol) ENSMUST00000245000.1 uc316owo.1 uc316owo.2 uc316owo.1 uc316owo.2 
ENSMUST00000245016.2 Gm56836 ENSMUST00000245016.2 Gm56836 (from geneSymbol) ENSMUST00000245016.1 uc316oxe.1 uc316oxe.2 uc316oxe.1 uc316oxe.2 
ENSMUST00000245039.2 Gm56531 ENSMUST00000245039.2 Gm56531 (from geneSymbol) ENSMUST00000245039.1 uc316oyb.1 uc316oyb.2 uc316oyb.1 uc316oyb.2 
ENSMUST00000245047.1 Chrna1os ENSMUST00000245047.1 Chrna1os (from geneSymbol) KY467873 uc316oyj.1 uc316oyj.1 
ENSMUST00000245056.2 Gm57240 ENSMUST00000245056.2 Gm57240 (from geneSymbol) ENSMUST00000245056.1 LF196534 uc316oys.1 uc316oys.2 uc316oys.1 uc316oys.2 
ENSMUST00000245084.2 Gm51903 ENSMUST00000245084.2 Gm51903 (from geneSymbol) ENSMUST00000245084.1 uc316ozu.1 uc316ozu.2 uc316ozu.1 uc316ozu.2 
ENSMUST00000245088.2 B130034C11Rik ENSMUST00000245088.2 B130034C11Rik (from geneSymbol) ENSMUST00000245088.1 KY467759 uc316ozy.1 uc316ozy.2 uc316ozy.1 uc316ozy.2 
ENSMUST00000245095.1 Gm33799 ENSMUST00000245095.1 Gm33799 (from geneSymbol) uc316paf.1 uc316paf.1 
ENSMUST00000245107.2 Gm57058 ENSMUST00000245107.2 Gm57058 (from geneSymbol) ENSMUST00000245107.1 uc316par.1 uc316par.2 uc316par.1 uc316par.2 
ENSMUST00000245110.2 2610029K11Rik ENSMUST00000245110.2 RIKEN cDNA 2610029K11 gene (from RefSeq NR_190060.1) ENSMUST00000245110.1 NR_190060 uc316pau.1 uc316pau.2 uc316pau.1 uc316pau.2 
ENSMUST00000245120.2 Gm57207 ENSMUST00000245120.2 Gm57207 (from geneSymbol) ENSMUST00000245120.1 uc316pbe.1 uc316pbe.2 uc316pbe.1 uc316pbe.2 
ENSMUST00000245145.2 1700017J07Rik ENSMUST00000245145.2 1700017J07Rik (from geneSymbol) ENSMUST00000245145.1 KY467922 uc316pcd.1 uc316pcd.2 uc316pcd.1 uc316pcd.2 
ENSMUST00000245158.2 Gm57094 ENSMUST00000245158.2 Gm57094 (from geneSymbol) AK146937 ENSMUST00000245158.1 uc316pcq.1 uc316pcq.2 uc316pcq.1 uc316pcq.2 
ENSMUST00000245168.1 Gm57095 ENSMUST00000245168.1 Gm57095 (from geneSymbol) uc316pda.1 uc316pda.1 
ENSMUST00000245177.2 Gm56837 ENSMUST00000245177.2 Gm56837 (from geneSymbol) ENSMUST00000245177.1 uc316pdj.1 uc316pdj.2 uc316pdj.1 uc316pdj.2 
ENSMUST00000245182.1 Gm9828 ENSMUST00000245182.1 Gm9828 (from geneSymbol) uc316pdo.1 uc316pdo.1 
ENSMUST00000245183.2 Gm57208 ENSMUST00000245183.2 Gm57208 (from geneSymbol) ENSMUST00000245183.1 uc316pdp.1 uc316pdp.2 uc316pdp.1 uc316pdp.2 
ENSMUST00000245201.1 Chaer1 ENSMUST00000245201.1 Chaer1 (from geneSymbol) uc316peh.1 uc316peh.1 
ENSMUST00000245210.2 Gm32840 ENSMUST00000245210.2 Gm32840 (from geneSymbol) ENSMUST00000245210.1 uc316peq.1 uc316peq.2 uc316peq.1 uc316peq.2 
ENSMUST00000245223.2 ENSMUSG00000121483 ENSMUST00000245223.2 ENSMUSG00000121483 (from geneSymbol) AK079804 ENSMUST00000245223.1 uc316pfd.1 uc316pfd.2 uc316pfd.1 uc316pfd.2 
ENSMUST00000245233.2 Gm56838 ENSMUST00000245233.2 Gm56838 (from geneSymbol) ENSMUST00000245233.1 uc316pfn.1 uc316pfn.2 uc316pfn.1 uc316pfn.2 
ENSMUST00000245244.2 AW112010 ENSMUST00000245244.2 AW112010 (from geneSymbol) EF660528 ENSMUST00000245244.1 uc316pfy.1 uc316pfy.2 uc316pfy.1 uc316pfy.2 
ENSMUST00000245247.2 Gm57020 ENSMUST00000245247.2 Gm57020 (from geneSymbol) ENSMUST00000245247.1 uc316pgb.1 uc316pgb.2 uc316pgb.1 uc316pgb.2 
ENSMUST00000245249.2 Gm57097 ENSMUST00000245249.2 Gm57097 (from geneSymbol) ENSMUST00000245249.1 uc316pgd.1 uc316pgd.2 uc316pgd.1 uc316pgd.2 
ENSMUST00000245271.2 Gm57021 ENSMUST00000245271.2 Gm57021 (from geneSymbol) ENSMUST00000245271.1 uc316pgz.1 uc316pgz.2 uc316pgz.1 uc316pgz.2 
ENSMUST00000245283.2 Gm56985 ENSMUST00000245283.2 Gm56985 (from geneSymbol) ENSMUST00000245283.1 uc316phl.1 uc316phl.2 uc316phl.1 uc316phl.2 
ENSMUST00000245296.2 Gm56892 ENSMUST00000245296.2 Gm56892 (from geneSymbol) ENSMUST00000245296.1 uc316phy.1 uc316phy.2 uc316phy.1 uc316phy.2 
ENSMUST00000245300.2 Gm38537 ENSMUST00000245300.2 Gm38537 (from geneSymbol) ENSMUST00000245300.1 uc316pic.1 uc316pic.2 uc316pic.1 uc316pic.2 
ENSMUST00000245302.2 Cerox1 ENSMUST00000245302.2 Cerox1 (from geneSymbol) AK079380 ENSMUST00000245302.1 uc316pie.1 uc316pie.2 uc316pie.1 uc316pie.2 
ENSMUST00000245305.2 Gm33694 ENSMUST00000245305.2 Gm33694 (from geneSymbol) ENSMUST00000245305.1 KY467936 uc316pih.1 uc316pih.2 uc316pih.1 uc316pih.2 
ENSMUST00000245310.2 Gm35510 ENSMUST00000245310.2 Gm35510 (from geneSymbol) ENSMUST00000245310.1 uc316pim.1 uc316pim.2 uc316pim.1 uc316pim.2 
ENSMUST00000245312.1 Gm39816 ENSMUST00000245312.1 Gm39816 (from geneSymbol) uc316pio.1 uc316pio.1 
ENSMUST00000245315.2 Gm21816 ENSMUST00000245315.2 Gm21816 (from geneSymbol) ENSMUST00000245315.1 uc316pir.1 uc316pir.2 uc316pir.1 uc316pir.2 
ENSMUST00000245320.2 Gm57022 ENSMUST00000245320.2 Gm57022 (from geneSymbol) ENSMUST00000245320.1 LF197650 uc316piw.1 uc316piw.2 uc316piw.1 uc316piw.2 
ENSMUST00000245323.2 Gm57356 ENSMUST00000245323.2 Gm57356 (from geneSymbol) ENSMUST00000245323.1 uc316piz.1 uc316piz.2 uc316piz.1 uc316piz.2 
ENSMUST00000245341.2 Gm19590 ENSMUST00000245341.2 Gm19590 (from geneSymbol) AK079675 ENSMUST00000245341.1 uc316pjq.1 uc316pjq.2 uc316pjq.1 uc316pjq.2 
ENSMUST00000245353.2 Gm57129 ENSMUST00000245353.2 Gm57129 (from geneSymbol) ENSMUST00000245353.1 uc316pkc.1 uc316pkc.2 uc316pkc.1 uc316pkc.2 
ENSMUST00000245361.2 Gm57099 ENSMUST00000245361.2 Gm57099 (from geneSymbol) AK139058 ENSMUST00000245361.1 uc316pkk.1 uc316pkk.2 uc316pkk.1 uc316pkk.2 
ENSMUST00000245376.2 Gm57357 ENSMUST00000245376.2 Gm57357 (from geneSymbol) ENSMUST00000245376.1 uc316pkz.1 uc316pkz.2 uc316pkz.1 uc316pkz.2 
ENSMUST00000245387.1 Gm20429 ENSMUST00000245387.1 Gm20429 (from geneSymbol) uc316plk.1 uc316plk.1 
ENSMUST00000245396.2 Gm56791 ENSMUST00000245396.2 Gm56791 (from geneSymbol) ENSMUST00000245396.1 uc316pls.1 uc316pls.2 uc316pls.1 uc316pls.2 
ENSMUST00000245398.2 Gm56656 ENSMUST00000245398.2 Gm56656 (from geneSymbol) ENSMUST00000245398.1 LF204747 uc316plu.1 uc316plu.2 uc316plu.1 uc316plu.2 
ENSMUST00000245403.2 Gm57130 ENSMUST00000245403.2 Gm57130 (from geneSymbol) ENSMUST00000245403.1 uc316plz.1 uc316plz.2 uc316plz.1 uc316plz.2 
ENSMUST00000245410.1 Gm56792 ENSMUST00000245410.1 Gm56792 (from geneSymbol) uc316pmg.1 uc316pmg.1 
ENSMUST00000245413.2 Gm56793 ENSMUST00000245413.2 Gm56793 (from geneSymbol) ENSMUST00000245413.1 uc316pmj.1 uc316pmj.2 uc316pmj.1 uc316pmj.2 
ENSMUST00000245419.1 Gm3764 ENSMUST00000245419.1 Gm3764 (from geneSymbol) AK140632 uc316pmo.1 uc316pmo.1 
ENSMUST00000245420.1 Gm56618 ENSMUST00000245420.1 Gm56618 (from geneSymbol) uc316pmp.1 uc316pmp.1 
ENSMUST00000245423.2 Gm57025 ENSMUST00000245423.2 Gm57025 (from geneSymbol) ENSMUST00000245423.1 uc316pms.1 uc316pms.2 uc316pms.1 uc316pms.2 
ENSMUST00000245427.2 Gm56893 ENSMUST00000245427.2 Gm56893 (from geneSymbol) ENSMUST00000245427.1 uc316pmw.1 uc316pmw.2 uc316pmw.1 uc316pmw.2 
ENSMUST00000245435.2 Gm53240 ENSMUST00000245435.2 Gm53240 (from geneSymbol) ENSMUST00000245435.1 uc316pne.1 uc316pne.2 uc316pne.1 uc316pne.2 
ENSMUST00000245443.2 Gm57210 ENSMUST00000245443.2 Gm57210 (from geneSymbol) ENSMUST00000245443.1 uc316pnm.1 uc316pnm.2 uc316pnm.1 uc316pnm.2 
ENSMUST00000245449.2 Gm56794 ENSMUST00000245449.2 Gm56794 (from geneSymbol) ENSMUST00000245449.1 uc316pns.1 uc316pns.2 uc316pns.1 uc316pns.2 
ENSMUST00000245461.2 Gm56936 ENSMUST00000245461.2 Gm56936 (from geneSymbol) AK003718 ENSMUST00000245461.1 uc316poe.1 uc316poe.2 uc316poe.1 uc316poe.2 
ENSMUST00000245463.1 Gm56657 ENSMUST00000245463.1 Gm56657 (from geneSymbol) uc316pog.1 uc316pog.1 
ENSMUST00000245472.2 Gm56840 ENSMUST00000245472.2 Gm56840 (from geneSymbol) ENSMUST00000245472.1 uc316pop.1 uc316pop.2 uc316pop.1 uc316pop.2 
ENSMUST00000245477.2 Gm57225 ENSMUST00000245477.2 Gm57225 (from geneSymbol) ENSMUST00000245477.1 uc316pou.1 uc316pou.2 uc316pou.1 uc316pou.2 
ENSMUST00000245481.1 Gm57132 ENSMUST00000245481.1 Gm57132 (from geneSymbol) uc316poy.1 uc316poy.1 
ENSMUST00000245490.2 Gm33302 ENSMUST00000245490.2 Gm33302 (from geneSymbol) ENSMUST00000245490.1 uc316pph.1 uc316pph.2 uc316pph.1 uc316pph.2 
ENSMUST00000245500.1 Gm29707 ENSMUST00000245500.1 Gm29707 (from geneSymbol) uc316ppr.1 uc316ppr.1 
ENSMUST00000245507.1 Gm56621 ENSMUST00000245507.1 Gm56621 (from geneSymbol) uc316ppy.1 uc316ppy.1 
ENSMUST00000245510.2 Gm56937 ENSMUST00000245510.2 Gm56937 (from geneSymbol) ENSMUST00000245510.1 uc316pqb.1 uc316pqb.2 uc316pqb.1 uc316pqb.2 
ENSMUST00000245523.2 Gm56841 ENSMUST00000245523.2 Gm56841 (from geneSymbol) ENSMUST00000245523.1 uc316pqn.1 uc316pqn.2 uc316pqn.1 uc316pqn.2 
ENSMUST00000245580.1 Hnf1aos1 ENSMUST00000245580.1 Hnf1aos1 (from geneSymbol) KY468058 uc316psp.1 uc316psp.1 
ENSMUST00000245598.2 Gm35686 ENSMUST00000245598.2 Gm35686 (from geneSymbol) ENSMUST00000245598.1 uc316pth.1 uc316pth.2 uc316pth.1 uc316pth.2 
ENSMUST00000245601.1 Silc1 ENSMUST00000245601.1 Silc1 (from geneSymbol) AK084401 uc316ptk.1 uc316ptk.1 
ENSMUST00000245607.2 Gm56536 ENSMUST00000245607.2 Gm56536 (from geneSymbol) ENSMUST00000245607.1 uc316ptq.1 uc316ptq.2 uc316ptq.1 uc316ptq.2 
ENSMUST00000245608.2 Gm56706 ENSMUST00000245608.2 Gm56706 (from geneSymbol) ENSMUST00000245608.1 uc316ptr.1 uc316ptr.2 uc316ptr.1 uc316ptr.2 
ENSMUST00000245612.2 Gm32046 ENSMUST00000245612.2 Gm32046 (from geneSymbol) ENSMUST00000245612.1 uc316ptv.1 uc316ptv.2 uc316ptv.1 uc316ptv.2 
ENSMUST00000245616.2 Gm11685 ENSMUST00000245616.2 Gm11685 (from geneSymbol) ENSMUST00000245616.1 KY467616 uc316ptz.1 uc316ptz.2 uc316ptz.1 uc316ptz.2 
ENSMUST00000245620.2 Gm43050 ENSMUST00000245620.2 Gm43050 (from geneSymbol) AK006202 ENSMUST00000245620.1 uc316pud.1 uc316pud.2 uc316pud.1 uc316pud.2 
ENSMUST00000245630.2 Gm54318 ENSMUST00000245630.2 Gm54318 (from geneSymbol) ENSMUST00000245630.1 uc316pun.1 uc316pun.2 uc316pun.1 uc316pun.2 
ENSMUST00000245643.2 Gm56795 ENSMUST00000245643.2 Gm56795 (from geneSymbol) ENSMUST00000245643.1 LF194000 uc316pva.1 uc316pva.2 uc316pva.1 uc316pva.2 
ENSMUST00000245646.2 Gm30893 ENSMUST00000245646.2 Gm30893 (from geneSymbol) ENSMUST00000245646.1 uc316pvd.1 uc316pvd.2 uc316pvd.1 uc316pvd.2 
ENSMUST00000245666.2 Gm57290 ENSMUST00000245666.2 Gm57290 (from geneSymbol) ENSMUST00000245666.1 uc316pvx.1 uc316pvx.2 uc316pvx.1 uc316pvx.2 
ENSMUST00000245667.2 Gm56845 ENSMUST00000245667.2 Gm56845 (from geneSymbol) ENSMUST00000245667.1 uc316pvy.1 uc316pvy.2 uc316pvy.1 uc316pvy.2 
ENSMUST00000245681.2 Gm57314 ENSMUST00000245681.2 Gm57314 (from geneSymbol) ENSMUST00000245681.1 uc316pwl.1 uc316pwl.2 uc316pwl.1 uc316pwl.2 
ENSMUST00000245685.2 Gm57026 ENSMUST00000245685.2 Gm57026 (from geneSymbol) ENSMUST00000245685.1 uc316pwp.1 uc316pwp.2 uc316pwp.1 uc316pwp.2 
ENSMUST00000245690.2 Gm56707 ENSMUST00000245690.2 Gm56707 (from geneSymbol) ENSMUST00000245690.1 uc316pwu.1 uc316pwu.2 uc316pwu.1 uc316pwu.2 
ENSMUST00000245703.2 Gm36462 ENSMUST00000245703.2 Gm36462 (from geneSymbol) ENSMUST00000245703.1 uc316pxh.1 uc316pxh.2 uc316pxh.1 uc316pxh.2 
ENSMUST00000245707.1 Gm57400 ENSMUST00000245707.1 Gm57400 (from geneSymbol) uc316pxl.1 uc316pxl.1 
ENSMUST00000245714.1 Gm57431 ENSMUST00000245714.1 Gm57431 (from geneSymbol) uc316pxs.1 uc316pxs.1 
ENSMUST00000245716.2 Gm57438 ENSMUST00000245716.2 Gm57438 (from geneSymbol) ENSMUST00000245716.1 LF193152 uc316pxu.1 uc316pxu.2 uc316pxu.1 uc316pxu.2 
ENSMUST00000245725.2 Gm57292 ENSMUST00000245725.2 Gm57292 (from geneSymbol) ENSMUST00000245725.1 uc316pyd.1 uc316pyd.2 uc316pyd.1 uc316pyd.2 
ENSMUST00000245727.2 Gm57060 ENSMUST00000245727.2 Gm57060 (from geneSymbol) ENSMUST00000245727.1 uc316pyf.1 uc316pyf.2 uc316pyf.1 uc316pyf.2 
ENSMUST00000245739.1 Gm32113 ENSMUST00000245739.1 predicted gene, 32113, transcript variant 1 (from RefSeq NR_166880.1) NR_166880 uc316pyr.1 uc316pyr.1 
ENSMUST00000245740.2 Serpina3h ENSMUST00000245740.2 Serpina3h (from geneSymbol) ENSMUST00000245740.1 MF496133 uc316pys.1 uc316pys.2 uc316pys.1 uc316pys.2 
ENSMUST00000245745.1 Gm19744 ENSMUST00000245745.1 Gm19744 (from geneSymbol) AK032387 uc316pyx.1 uc316pyx.1 
ENSMUST00000245748.2 Gm57213 ENSMUST00000245748.2 Gm57213 (from geneSymbol) ENSMUST00000245748.1 uc316pza.1 uc316pza.2 uc316pza.1 uc316pza.2 
ENSMUST00000245758.2 Gm56683 ENSMUST00000245758.2 Gm56683 (from geneSymbol) AK043391 ENSMUST00000245758.1 uc316pzk.1 uc316pzk.2 uc316pzk.1 uc316pzk.2 
ENSMUST00000245761.1 A530040E14Rik ENSMUST00000245761.1 A530040E14Rik (from geneSymbol) AK142678 uc316pzn.1 uc316pzn.1 
ENSMUST00000245764.2 Gm34235 ENSMUST00000245764.2 predicted gene, 34235 (from RefSeq NR_166890.1) ENSMUST00000245764.1 NR_166890 uc316pzq.1 uc316pzq.2 uc316pzq.1 uc316pzq.2 
ENSMUST00000245766.2 Gm56626 ENSMUST00000245766.2 Gm56626 (from geneSymbol) ENSMUST00000245766.1 uc316pzs.1 uc316pzs.2 uc316pzs.1 uc316pzs.2 
ENSMUST00000245773.2 Gm56538 ENSMUST00000245773.2 Gm56538 (from geneSymbol) ENSMUST00000245773.1 uc316pzz.1 uc316pzz.2 uc316pzz.1 uc316pzz.2 
ENSMUST00000245774.2 Gm57293 ENSMUST00000245774.2 Gm57293 (from geneSymbol) ENSMUST00000245774.1 uc316qaa.1 uc316qaa.2 uc316qaa.1 uc316qaa.2 
ENSMUST00000245778.1 4933406C10Rik ENSMUST00000245778.1 4933406C10Rik (from geneSymbol) AK041289 uc316qad.1 uc316qad.1 
ENSMUST00000245779.2 Gm57360 ENSMUST00000245779.2 Gm57360 (from geneSymbol) ENSMUST00000245779.1 uc316qae.1 uc316qae.2 uc316qae.1 uc316qae.2 
ENSMUST00000245787.2 Gm56711 ENSMUST00000245787.2 Gm56711 (from geneSymbol) ENSMUST00000245787.1 uc316qam.1 uc316qam.2 uc316qam.1 uc316qam.2 
ENSMUST00000245789.2 Gm56577 ENSMUST00000245789.2 Gm56577 (from geneSymbol) AB033523 ENSMUST00000245789.1 uc316qao.1 uc316qao.2 uc316qao.1 uc316qao.2 
ENSMUST00000245790.2 Gm56741 ENSMUST00000245790.2 Gm56741 (from geneSymbol) ENSMUST00000245790.1 uc316qap.1 uc316qap.2 uc316qap.1 uc316qap.2 
ENSMUST00000245792.1 Gm56810 ENSMUST00000245792.1 Gm56810 (from geneSymbol) uc316qar.1 uc316qar.1 
ENSMUST00000245819.2 Gm56686 ENSMUST00000245819.2 Gm56686 (from geneSymbol) AK038641 ENSMUST00000245819.1 uc316qbs.1 uc316qbs.2 uc316qbs.1 uc316qbs.2 
ENSMUST00000245822.2 Gm56578 ENSMUST00000245822.2 Gm56578 (from geneSymbol) AK134220 ENSMUST00000245822.1 uc316qbv.1 uc316qbv.2 uc316qbv.1 uc316qbv.2 
ENSMUST00000245848.2 Gm57363 ENSMUST00000245848.2 Gm57363 (from geneSymbol) ENSMUST00000245848.1 uc316qcu.1 uc316qcu.2 uc316qcu.1 uc316qcu.2 
ENSMUST00000245851.2 Gm57049 ENSMUST00000245851.2 Gm57049 (from geneSymbol) ENSMUST00000245851.1 uc316qcx.1 uc316qcx.2 uc316qcx.1 uc316qcx.2 
ENSMUST00000245852.2 Gm46129 ENSMUST00000245852.2 Gm46129 (from geneSymbol) ENSMUST00000245852.1 uc316qcy.1 uc316qcy.2 uc316qcy.1 uc316qcy.2 
ENSMUST00000245853.2 Gm10858 ENSMUST00000245853.2 Gm10858 (from geneSymbol) ENSMUST00000245853.1 uc316qcz.1 uc316qcz.2 uc316qcz.1 uc316qcz.2 
ENSMUST00000245863.2 Gm56709 ENSMUST00000245863.2 Gm56709 (from geneSymbol) ENSMUST00000245863.1 uc316qdj.1 uc316qdj.2 uc316qdj.1 uc316qdj.2 
ENSMUST00000245867.1 Gm56579 ENSMUST00000245867.1 Gm56579 (from geneSymbol) uc316qdn.1 uc316qdn.1 
ENSMUST00000245874.2 Gm57104 ENSMUST00000245874.2 Gm57104 (from geneSymbol) AK146114 ENSMUST00000245874.1 uc316qdu.1 uc316qdu.2 uc316qdu.1 uc316qdu.2 
ENSMUST00000245878.2 Gm34225 ENSMUST00000245878.2 Gm34225 (from geneSymbol) ENSMUST00000245878.1 uc316qdy.1 uc316qdy.2 uc316qdy.1 uc316qdy.2 
ENSMUST00000245879.1 2810001G20Rik ENSMUST00000245879.1 2810001G20Rik (from geneSymbol) AK007927 uc316qdz.1 uc316qdz.1 
ENSMUST00000245880.2 Gm57028 ENSMUST00000245880.2 Gm57028 (from geneSymbol) ENSMUST00000245880.1 LF204662 uc316qea.1 uc316qea.2 uc316qea.1 uc316qea.2 
ENSMUST00000245882.2 BE692007 ENSMUST00000245882.2 BE692007 (from geneSymbol) AK079938 ENSMUST00000245882.1 uc316qec.1 uc316qec.2 uc316qec.1 uc316qec.2 
ENSMUST00000245888.1 Larp4b ENSMUST00000245888.1 Larp4b (from geneSymbol) LF199379 uc316qei.1 uc316qei.1 
ENSMUST00000245900.2 Gm56993 ENSMUST00000245900.2 Gm56993 (from geneSymbol) ENSMUST00000245900.1 uc316qeu.1 uc316qeu.2 uc316qeu.1 uc316qeu.2 
ENSMUST00000245903.2 Gm35137 ENSMUST00000245903.2 Gm35137 (from geneSymbol) ENSMUST00000245903.1 uc316qex.1 uc316qex.2 uc316qex.1 uc316qex.2 
ENSMUST00000245904.2 Gm30307 ENSMUST00000245904.2 Gm30307 (from geneSymbol) AK033297 ENSMUST00000245904.1 uc316qey.1 uc316qey.2 uc316qey.1 uc316qey.2 
ENSMUST00000245908.1 Gm57029 ENSMUST00000245908.1 Gm57029 (from geneSymbol) LF197582 uc316qfc.1 uc316qfc.1 
ENSMUST00000245910.2 Gm36629 ENSMUST00000245910.2 Gm36629 (from geneSymbol) ENSMUST00000245910.1 uc316qfe.1 uc316qfe.2 uc316qfe.1 uc316qfe.2 
ENSMUST00000245913.1 Gm57030 ENSMUST00000245913.1 Gm57030 (from geneSymbol) uc316qfh.1 uc316qfh.1 
ENSMUST00000245927.2 Gm13822 ENSMUST00000245927.2 predicted gene 13822 (from RefSeq NR_166682.1) ENSMUST00000245927.1 NR_166682 uc316qfv.1 uc316qfv.2 uc316qfv.1 uc316qfv.2 
ENSMUST00000245944.2 Gm56660 ENSMUST00000245944.2 Gm56660 (from geneSymbol) AK082962 ENSMUST00000245944.1 uc316qgl.1 uc316qgl.2 uc316qgl.1 uc316qgl.2 
ENSMUST00000245954.1 Gm56764 ENSMUST00000245954.1 Gm56764 (from geneSymbol) LF199778 uc316qgv.1 uc316qgv.1 
ENSMUST00000245960.2 Gm57032 ENSMUST00000245960.2 Gm57032 (from geneSymbol) ENSMUST00000245960.1 LF197847 uc316qhb.1 uc316qhb.2 uc316qhb.1 uc316qhb.2 
ENSMUST00000245967.1 1700031C06Rik ENSMUST00000245967.1 1700031C06Rik (from geneSymbol) uc316qhi.1 uc316qhi.1 
ENSMUST00000245975.1 Gm56539 ENSMUST00000245975.1 Gm56539 (from geneSymbol) uc316qhq.1 uc316qhq.1 
ENSMUST00000245979.2 Gm57106 ENSMUST00000245979.2 Gm57106 (from geneSymbol) ENSMUST00000245979.1 uc316qhu.1 uc316qhu.2 uc316qhu.1 uc316qhu.2 
ENSMUST00000245982.2 Gm57215 ENSMUST00000245982.2 Gm57215 (from geneSymbol) ENSMUST00000245982.1 uc316qhx.1 uc316qhx.2 uc316qhx.1 uc316qhx.2 
ENSMUST00000245998.2 Gm10369 ENSMUST00000245998.2 Gm10369 (from geneSymbol) AK142429 ENSMUST00000245998.1 uc316qin.1 uc316qin.2 uc316qin.1 uc316qin.2 
ENSMUST00000246002.2 2310043M15Rik ENSMUST00000246002.2 2310043M15Rik (from geneSymbol) AK009785 ENSMUST00000246002.1 uc316qir.1 uc316qir.2 uc316qir.1 uc316qir.2 
ENSMUST00000246008.2 Gm57134 ENSMUST00000246008.2 Gm57134 (from geneSymbol) ENSMUST00000246008.1 uc316qix.1 uc316qix.2 uc316qix.1 uc316qix.2 
ENSMUST00000246018.2 Gm57135 ENSMUST00000246018.2 Gm57135 (from geneSymbol) ENSMUST00000246018.1 uc316qjh.1 uc316qjh.2 uc316qjh.1 uc316qjh.2 
ENSMUST00000246020.2 Gm56540 ENSMUST00000246020.2 Gm56540 (from geneSymbol) ENSMUST00000246020.1 uc316qjj.1 uc316qjj.2 uc316qjj.1 uc316qjj.2 
ENSMUST00000246025.1 Gm36012 ENSMUST00000246025.1 predicted gene, 36012 (from RefSeq NR_168609.1) NR_168609 uc316qjo.1 uc316qjo.1 
ENSMUST00000246033.2 Gm56687 ENSMUST00000246033.2 Gm56687 (from geneSymbol) ENSMUST00000246033.1 uc316qjw.1 uc316qjw.2 uc316qjw.1 uc316qjw.2 
ENSMUST00000246038.2 Gm57245 ENSMUST00000246038.2 Gm57245 (from geneSymbol) AK020472 ENSMUST00000246038.1 uc316qkb.1 uc316qkb.2 uc316qkb.1 uc316qkb.2 
ENSMUST00000246051.2 Gm39993 ENSMUST00000246051.2 Gm39993 (from geneSymbol) ENSMUST00000246051.1 uc316qko.1 uc316qko.2 uc316qko.1 uc316qko.2 
ENSMUST00000246060.2 Gm56994 ENSMUST00000246060.2 Gm56994 (from geneSymbol) ENSMUST00000246060.1 uc316qkw.1 uc316qkw.2 uc316qkw.1 uc316qkw.2 
ENSMUST00000246069.2 Gm57364 ENSMUST00000246069.2 Gm57364 (from geneSymbol) ENSMUST00000246069.1 uc316qlf.1 uc316qlf.2 uc316qlf.1 uc316qlf.2 
ENSMUST00000246071.2 D730003I15Rik ENSMUST00000246071.2 D730003I15Rik (from geneSymbol) AK049444 ENSMUST00000246071.1 uc316qlh.1 uc316qlh.2 uc316qlh.1 uc316qlh.2 
ENSMUST00000246082.1 B930046K06Rik ENSMUST00000246082.1 B930046K06Rik (from geneSymbol) uc316qls.1 uc316qls.1 
ENSMUST00000246085.1 Gm56940 ENSMUST00000246085.1 Gm56940 (from geneSymbol) uc316qlv.1 uc316qlv.1 
ENSMUST00000246091.1 Gm56991 ENSMUST00000246091.1 Gm56991 (from geneSymbol) uc316qmb.1 uc316qmb.1 
ENSMUST00000246092.1 Gm57035 ENSMUST00000246092.1 Gm57035 (from geneSymbol) uc316qmc.1 uc316qmc.1 
ENSMUST00000246100.2 Gm56768 ENSMUST00000246100.2 Gm56768 (from geneSymbol) ENSMUST00000246100.1 LF199951 uc316qmj.1 uc316qmj.2 uc316qmj.1 uc316qmj.2 
ENSMUST00000246106.2 Gm56765 ENSMUST00000246106.2 Gm56765 (from geneSymbol) ENSMUST00000246106.1 uc316qmp.1 uc316qmp.2 uc316qmp.1 uc316qmp.2 
ENSMUST00000246122.2 Gm57319 ENSMUST00000246122.2 Gm57319 (from geneSymbol) ENSMUST00000246122.1 uc316qne.1 uc316qne.2 uc316qne.1 uc316qne.2 
ENSMUST00000246123.2 Gm57216 ENSMUST00000246123.2 Gm57216 (from geneSymbol) ENSMUST00000246123.1 uc316qnf.1 uc316qnf.2 uc316qnf.1 uc316qnf.2 
ENSMUST00000246125.2 1700024P12Rik ENSMUST00000246125.2 1700024P12Rik (from geneSymbol) ENSMUST00000246125.1 LF200853 uc316qnh.1 uc316qnh.2 uc316qnh.1 uc316qnh.2 
ENSMUST00000246131.2 Gm57039 ENSMUST00000246131.2 Gm57039 (from geneSymbol) ENSMUST00000246131.1 uc316qnn.1 uc316qnn.2 uc316qnn.1 uc316qnn.2 
ENSMUST00000246137.2 Gm56797 ENSMUST00000246137.2 Gm56797 (from geneSymbol) ENSMUST00000246137.1 uc316qnt.1 uc316qnt.2 uc316qnt.1 uc316qnt.2 
ENSMUST00000246178.2 Gm57299 ENSMUST00000246178.2 Gm57299 (from geneSymbol) ENSMUST00000246178.1 uc316qph.1 uc316qph.2 uc316qph.1 uc316qph.2 
ENSMUST00000246183.2 Gm56582 ENSMUST00000246183.2 Gm56582 (from geneSymbol) ENSMUST00000246183.1 LF199542 uc316qpm.1 uc316qpm.2 uc316qpm.1 uc316qpm.2 
ENSMUST00000246191.2 Gm57435 ENSMUST00000246191.2 Gm57435 (from geneSymbol) ENSMUST00000246191.1 uc316qpu.1 uc316qpu.2 uc316qpu.1 uc316qpu.2 
ENSMUST00000246198.1 Gm56684 ENSMUST00000246198.1 Gm56684 (from geneSymbol) uc316qqb.1 uc316qqb.1 
ENSMUST00000246199.2 Gm57368 ENSMUST00000246199.2 Gm57368 (from geneSymbol) ENSMUST00000246199.1 uc316qqc.1 uc316qqc.2 uc316qqc.1 uc316qqc.2 
ENSMUST00000246200.2 Gm57369 ENSMUST00000246200.2 Gm57369 (from geneSymbol) ENSMUST00000246200.1 uc316qqd.1 uc316qqd.2 uc316qqd.1 uc316qqd.2 
ENSMUST00000246212.1 Gm56800 ENSMUST00000246212.1 Gm56800 (from geneSymbol) uc316qqp.1 uc316qqp.1 
ENSMUST00000246214.2 Gm56560 ENSMUST00000246214.2 Gm56560 (from geneSymbol) ENSMUST00000246214.1 uc316qqr.1 uc316qqr.2 uc316qqr.1 uc316qqr.2 
ENSMUST00000246218.1 Gm56583 ENSMUST00000246218.1 Gm56583 (from geneSymbol) uc316qqv.1 uc316qqv.1 
ENSMUST00000246219.1 Gm57217 ENSMUST00000246219.1 Gm57217 (from geneSymbol) LF196029 uc316qqw.1 uc316qqw.1 
ENSMUST00000246220.2 3300002P09Rik ENSMUST00000246220.2 RIKEN cDNA 3300002P09 gene (from RefSeq NR_190111.1) ENSMUST00000246220.1 NR_190111 uc316qqx.1 uc316qqx.2 uc316qqx.1 uc316qqx.2 
ENSMUST00000246229.2 Gm57139 ENSMUST00000246229.2 Gm57139 (from geneSymbol) ENSMUST00000246229.1 uc316qrg.1 uc316qrg.2 uc316qrg.1 uc316qrg.2 
ENSMUST00000246242.1 5033425G24Rik ENSMUST00000246242.1 5033425G24Rik (from geneSymbol) AK017193 uc316qrt.1 uc316qrt.1 
ENSMUST00000246253.2 Gm56714 ENSMUST00000246253.2 Gm56714 (from geneSymbol) ENSMUST00000246253.1 uc316qse.1 uc316qse.2 uc316qse.1 uc316qse.2 
ENSMUST00000246257.2 Gm56663 ENSMUST00000246257.2 Gm56663 (from geneSymbol) ENSMUST00000246257.1 uc316qsi.1 uc316qsi.2 uc316qsi.1 uc316qsi.2 
ENSMUST00000246259.2 Gm56766 ENSMUST00000246259.2 Gm56766 (from geneSymbol) ENSMUST00000246259.1 uc316qsk.1 uc316qsk.2 uc316qsk.1 uc316qsk.2 
ENSMUST00000246268.2 Gm56664 ENSMUST00000246268.2 Gm56664 (from geneSymbol) AK085897 ENSMUST00000246268.1 uc316qst.1 uc316qst.2 uc316qst.1 uc316qst.2 
ENSMUST00000246279.2 Gm56552 ENSMUST00000246279.2 Gm56552 (from geneSymbol) ENSMUST00000246279.1 uc316qtd.1 uc316qtd.2 uc316qtd.1 uc316qtd.2 
ENSMUST00000246280.2 Gm57140 ENSMUST00000246280.2 Gm57140 (from geneSymbol) ENSMUST00000246280.1 uc316qte.1 uc316qte.2 uc316qte.1 uc316qte.2 
ENSMUST00000246281.2 Gm57243 ENSMUST00000246281.2 Gm57243 (from geneSymbol) ENSMUST00000246281.1 uc316qtf.1 uc316qtf.2 uc316qtf.1 uc316qtf.2 
ENSMUST00000246323.1 Gm56665 ENSMUST00000246323.1 Gm56665 (from geneSymbol) uc316quv.1 uc316quv.1 
ENSMUST00000246326.1 Gm56666 ENSMUST00000246326.1 Gm56666 (from geneSymbol) uc316quy.1 uc316quy.1 
ENSMUST00000246327.2 Gm56995 ENSMUST00000246327.2 Gm56995 (from geneSymbol) ENSMUST00000246327.1 uc316quz.1 uc316quz.2 uc316quz.1 uc316quz.2 
ENSMUST00000246328.1 Gm56543 ENSMUST00000246328.1 Gm56543 (from geneSymbol) AB349756 uc316qva.1 uc316qva.1 
ENSMUST00000246338.2 Gm57246 ENSMUST00000246338.2 Gm57246 (from geneSymbol) ENSMUST00000246338.1 LF196526 uc316qvk.1 uc316qvk.2 uc316qvk.1 uc316qvk.2 
ENSMUST00000246339.2 Gm41178 ENSMUST00000246339.2 Gm41178 (from geneSymbol) ENSMUST00000246339.1 uc316qvl.1 uc316qvl.2 uc316qvl.1 uc316qvl.2 
ENSMUST00000246340.2 Gm57238 ENSMUST00000246340.2 Gm57238 (from geneSymbol) ENSMUST00000246340.1 uc316qvm.1 uc316qvm.2 uc316qvm.1 uc316qvm.2 
ENSMUST00000246360.2 Gm56544 ENSMUST00000246360.2 Gm56544 (from geneSymbol) ENSMUST00000246360.1 uc316qwf.1 uc316qwf.2 uc316qwf.1 uc316qwf.2 
ENSMUST00000246374.1 Gm56667 ENSMUST00000246374.1 Gm56667 (from geneSymbol) uc316qwt.1 uc316qwt.1 
ENSMUST00000246377.1 Gm56668 ENSMUST00000246377.1 Gm56668 (from geneSymbol) uc316qww.1 uc316qww.1 
ENSMUST00000246381.2 Gm57440 ENSMUST00000246381.2 Gm57440 (from geneSymbol) ENSMUST00000246381.1 uc316qxa.1 uc316qxa.2 uc316qxa.1 uc316qxa.2 
ENSMUST00000246403.1 Gm11844 ENSMUST00000246403.1 Gm11844 (from geneSymbol) KY467969 uc316qxv.1 uc316qxv.1 
ENSMUST00000246405.1 Gm56805 ENSMUST00000246405.1 Gm56805 (from geneSymbol) uc316qxx.1 uc316qxx.1 
ENSMUST00000246407.2 Gm56623 ENSMUST00000246407.2 Gm56623 (from geneSymbol) ENSMUST00000246407.1 uc316qxz.1 uc316qxz.2 uc316qxz.1 uc316qxz.2 
ENSMUST00000246416.1 Gm57036 ENSMUST00000246416.1 Gm57036 (from geneSymbol) K00162 uc316qyi.1 uc316qyi.1 
ENSMUST00000246422.2 2700016F22Rik ENSMUST00000246422.2 2700016F22Rik (from geneSymbol) ENSMUST00000246422.1 LF194721 uc316qyo.1 uc316qyo.2 uc316qyo.1 uc316qyo.2 
ENSMUST00000246429.2 Gm39283 ENSMUST00000246429.2 Gm39283 (from geneSymbol) ENSMUST00000246429.1 uc316qyu.1 uc316qyu.2 uc316qyu.1 uc316qyu.2 
ENSMUST00000246435.2 Gm39529 ENSMUST00000246435.2 predicted gene, 39529, transcript variant 2 (from RefSeq NR_166893.1) ENSMUST00000246435.1 NR_166893 uc316qza.1 uc316qza.2 uc316qza.1 uc316qza.2 
ENSMUST00000246441.1 Gm57158 ENSMUST00000246441.1 Gm57158 (from geneSymbol) uc316qzg.1 uc316qzg.1 
ENSMUST00000246442.2 Gm56996 ENSMUST00000246442.2 Gm56996 (from geneSymbol) ENSMUST00000246442.1 uc316qzh.1 uc316qzh.2 uc316qzh.1 uc316qzh.2 
ENSMUST00000246447.2 Gm29538 ENSMUST00000246447.2 Gm29538 (from geneSymbol) ENSMUST00000246447.1 uc316qzm.1 uc316qzm.2 uc316qzm.1 uc316qzm.2 
ENSMUST00000246450.2 Gm35287 ENSMUST00000246450.2 Gm35287 (from geneSymbol) ENSMUST00000246450.1 uc316qzp.1 uc316qzp.2 uc316qzp.1 uc316qzp.2 
ENSMUST00000246460.2 Gm56767 ENSMUST00000246460.2 Gm56767 (from geneSymbol) ENSMUST00000246460.1 uc316qzz.1 uc316qzz.2 uc316qzz.1 uc316qzz.2 
ENSMUST00000246464.2 Gm57306 ENSMUST00000246464.2 Gm57306 (from geneSymbol) ENSMUST00000246464.1 uc316rad.1 uc316rad.2 uc316rad.1 uc316rad.2 
ENSMUST00000246470.1 Gm57037 ENSMUST00000246470.1 Gm57037 (from geneSymbol) uc316raj.1 uc316raj.1 
ENSMUST00000246473.2 Gm56806 ENSMUST00000246473.2 Gm56806 (from geneSymbol) ENSMUST00000246473.1 LF194170 uc316ram.1 uc316ram.2 uc316ram.1 uc316ram.2 
ENSMUST00000246485.1 Gm56952 ENSMUST00000246485.1 Gm56952 (from geneSymbol) AK155703 uc316ray.1 uc316ray.1 
ENSMUST00000246493.1 Gm56812 ENSMUST00000246493.1 Gm56812 (from geneSymbol) AK082182 uc316rbg.1 uc316rbg.1 
ENSMUST00000246498.2 Gm57145 ENSMUST00000246498.2 Gm57145 (from geneSymbol) ENSMUST00000246498.1 uc316rbl.1 uc316rbl.2 uc316rbl.1 uc316rbl.2 
ENSMUST00000246501.2 Gm56895 ENSMUST00000246501.2 Gm56895 (from geneSymbol) ENSMUST00000246501.1 uc316rbo.1 uc316rbo.2 uc316rbo.1 uc316rbo.2 
ENSMUST00000246511.2 Gm56736 ENSMUST00000246511.2 Gm56736 (from geneSymbol) ENSMUST00000246511.1 uc316rby.1 uc316rby.2 uc316rby.1 uc316rby.2 
ENSMUST00000246516.1 Gm56585 ENSMUST00000246516.1 Gm56585 (from geneSymbol) uc316rcd.1 uc316rcd.1 
ENSMUST00000246517.2 Gm56896 ENSMUST00000246517.2 Gm56896 (from geneSymbol) ENSMUST00000246517.1 uc316rce.1 uc316rce.2 uc316rce.1 uc316rce.2 
ENSMUST00000246530.1 Gm57038 ENSMUST00000246530.1 Gm57038 (from geneSymbol) LF197510 uc316rcr.1 uc316rcr.1 
ENSMUST00000246532.2 Gm30716 ENSMUST00000246532.2 Gm30716 (from geneSymbol) ENSMUST00000246532.1 KY467710 uc316rct.1 uc316rct.2 uc316rct.1 uc316rct.2 
ENSMUST00000246534.1 Gm57147 ENSMUST00000246534.1 Gm57147 (from geneSymbol) AK208666 uc316rcv.1 uc316rcv.1 
ENSMUST00000246536.2 Gm56685 ENSMUST00000246536.2 Gm56685 (from geneSymbol) ENSMUST00000246536.1 uc316rcx.1 uc316rcx.2 uc316rcx.1 uc316rcx.2 
ENSMUST00000246561.1 Gm56998 ENSMUST00000246561.1 Gm56998 (from geneSymbol) uc316rdw.1 uc316rdw.1 
ENSMUST00000246564.1 Gm39090 ENSMUST00000246564.1 predicted gene, 39090, transcript variant 4 (from RefSeq NR_176654.1) NR_176654 uc316rdz.1 uc316rdz.1 
ENSMUST00000246565.1 9930105H17Rik ENSMUST00000246565.1 9930105H17Rik (from geneSymbol) uc316rea.1 uc316rea.1 
ENSMUST00000246569.2 6230400D17Rik ENSMUST00000246569.2 6230400D17Rik (from geneSymbol) AK018074 ENSMUST00000246569.1 uc316ree.1 uc316ree.2 uc316ree.1 uc316ree.2 
ENSMUST00000246572.1 Gm56853 ENSMUST00000246572.1 Gm56853 (from geneSymbol) uc316reh.1 uc316reh.1 
ENSMUST00000246575.1 Gm57044 ENSMUST00000246575.1 predicted gene, 40564 (from RefSeq NR_175879.1) NR_175879 uc316rek.1 uc316rek.1 
ENSMUST00000246577.1 Gm57123 ENSMUST00000246577.1 Gm57123 (from geneSymbol) LF194451 uc316rem.1 uc316rem.1 
ENSMUST00000246581.2 Gm56808 ENSMUST00000246581.2 Gm56808 (from geneSymbol) ENSMUST00000246581.1 uc316req.1 uc316req.2 uc316req.1 uc316req.2 
ENSMUST00000246591.2 Gm12108 ENSMUST00000246591.2 Gm12108 (from geneSymbol) AK032705 ENSMUST00000246591.1 uc316rfa.1 uc316rfa.2 uc316rfa.1 uc316rfa.2 
ENSMUST00000246593.2 Gm57375 ENSMUST00000246593.2 Gm57375 (from geneSymbol) ENSMUST00000246593.1 uc316rfc.1 uc316rfc.2 uc316rfc.1 uc316rfc.2 
ENSMUST00000246600.1 Gm57054 ENSMUST00000246600.1 Gm57054 (from geneSymbol) uc316rfj.1 uc316rfj.1 
ENSMUST00000246605.2 Gm56809 ENSMUST00000246605.2 Gm56809 (from geneSymbol) BC128341 ENSMUST00000246605.1 uc316rfo.1 uc316rfo.2 uc316rfo.1 uc316rfo.2 
ENSMUST00000246607.2 Gm57040 ENSMUST00000246607.2 Gm57040 (from geneSymbol) ENSMUST00000246607.1 uc316rfq.1 uc316rfq.2 uc316rfq.1 uc316rfq.2 
ENSMUST00000246612.1 Gm56627 ENSMUST00000246612.1 Gm56627 (from geneSymbol) uc316rfv.1 uc316rfv.1 
ENSMUST00000246626.2 Gm56545 ENSMUST00000246626.2 Gm56545 (from geneSymbol) ENSMUST00000246626.1 uc316rgj.1 uc316rgj.2 uc316rgj.1 uc316rgj.2 
ENSMUST00000246627.1 Gm57241 ENSMUST00000246627.1 Gm57241 (from geneSymbol) LF196201 uc316rgk.1 uc316rgk.1 
ENSMUST00000246633.2 2010002M09Rik ENSMUST00000246633.2 2010002M09Rik (from geneSymbol) ENSMUST00000246633.1 LF194127 uc316rgq.1 uc316rgq.2 uc316rgq.1 uc316rgq.2 
ENSMUST00000246654.2 Gm57003 ENSMUST00000246654.2 Gm57003 (from geneSymbol) AK144316 ENSMUST00000246654.1 uc316rhl.1 uc316rhl.2 uc316rhl.1 uc316rhl.2 
ENSMUST00000246656.2 B230208B08Rik ENSMUST00000246656.2 B230208B08Rik (from geneSymbol) ENSMUST00000246656.1 uc316rhn.1 uc316rhn.2 uc316rhn.1 uc316rhn.2 
ENSMUST00000246657.2 Gm57004 ENSMUST00000246657.2 Gm57004 (from geneSymbol) ENSMUST00000246657.1 uc316rho.1 uc316rho.2 uc316rho.1 uc316rho.2 
ENSMUST00000246659.2 F730311O21Rik ENSMUST00000246659.2 F730311O21Rik (from geneSymbol) AK155877 ENSMUST00000246659.1 uc316rhq.1 uc316rhq.2 uc316rhq.1 uc316rhq.2 
ENSMUST00000246660.2 Gm56967 ENSMUST00000246660.2 Gm56967 (from geneSymbol) ENSMUST00000246660.1 uc316rhr.1 uc316rhr.2 uc316rhr.1 uc316rhr.2 
ENSMUST00000246661.2 Gm56624 ENSMUST00000246661.2 Gm56624 (from geneSymbol) ENSMUST00000246661.1 uc316rhs.1 uc316rhs.2 uc316rhs.1 uc316rhs.2 
ENSMUST00000246663.1 Gm56625 ENSMUST00000246663.1 Gm56625 (from geneSymbol) uc316rhu.1 uc316rhu.1 
ENSMUST00000246667.2 Gm57452 ENSMUST00000246667.2 Gm57452 (from geneSymbol) ENSMUST00000246667.1 uc316rhy.1 uc316rhy.2 uc316rhy.1 uc316rhy.2 
ENSMUST00000246669.2 Snhg7 ENSMUST00000246669.2 Snhg7 (from geneSymbol) BC046478 ENSMUST00000246669.1 uc316ria.1 uc316ria.2 uc316ria.1 uc316ria.2 
ENSMUST00000246671.2 Gm57005 ENSMUST00000246671.2 Gm57005 (from geneSymbol) ENSMUST00000246671.1 uc316ric.1 uc316ric.2 uc316ric.1 uc316ric.2 
ENSMUST00000246683.2 Gm57380 ENSMUST00000246683.2 Gm57380 (from geneSymbol) ENSMUST00000246683.1 uc316rio.1 uc316rio.2 uc316rio.1 uc316rio.2 
ENSMUST00000246690.2 Gm56855 ENSMUST00000246690.2 Gm56855 (from geneSymbol) ENSMUST00000246690.1 uc316riv.1 uc316riv.2 uc316riv.1 uc316riv.2 
ENSMUST00000246707.1 Gm57125 ENSMUST00000246707.1 Gm57125 (from geneSymbol) uc316rjm.1 uc316rjm.1 
ENSMUST00000246708.2 Gm56813 ENSMUST00000246708.2 Gm56813 (from geneSymbol) ENSMUST00000246708.1 uc316rjn.1 uc316rjn.2 uc316rjn.1 uc316rjn.2 
ENSMUST00000246710.1 Gm20186 ENSMUST00000246710.1 Gm20186 (from geneSymbol) uc316rjp.1 uc316rjp.1 
ENSMUST00000246716.1 Gm56877 ENSMUST00000246716.1 Gm56877 (from geneSymbol) AK080749 uc316rju.1 uc316rju.1 
ENSMUST00000246718.2 Gm57218 ENSMUST00000246718.2 Gm57218 (from geneSymbol) ENSMUST00000246718.1 uc316rjw.1 uc316rjw.2 uc316rjw.1 uc316rjw.2 
ENSMUST00000246720.1 Gm56856 ENSMUST00000246720.1 Gm56856 (from geneSymbol) uc316rjy.1 uc316rjy.1 
ENSMUST00000246721.2 Gm56899 ENSMUST00000246721.2 Gm56899 (from geneSymbol) ENSMUST00000246721.1 uc316rjz.1 uc316rjz.2 uc316rjz.1 uc316rjz.2 
ENSMUST00000246723.1 Gm56587 ENSMUST00000246723.1 Gm56587 (from geneSymbol) uc316rkb.1 uc316rkb.1 
ENSMUST00000246725.2 Gm56589 ENSMUST00000246725.2 Gm56589 (from geneSymbol) AK145240 ENSMUST00000246725.1 uc316rkd.1 uc316rkd.2 uc316rkd.1 uc316rkd.2 
ENSMUST00000246729.2 Gm28818 ENSMUST00000246729.2 Gm28818 (from geneSymbol) AK144102 ENSMUST00000246729.1 uc316rkh.1 uc316rkh.2 uc316rkh.1 uc316rkh.2 
ENSMUST00000246735.1 Gm56971 ENSMUST00000246735.1 Gm56971 (from geneSymbol) uc316rkn.1 uc316rkn.1 
ENSMUST00000246744.1 Gm56588 ENSMUST00000246744.1 Gm56588 (from geneSymbol) AK135063 uc316rkv.1 uc316rkv.1 
ENSMUST00000246750.1 Gm56718 ENSMUST00000246750.1 Gm56718 (from geneSymbol) uc316rlb.1 uc316rlb.1 
ENSMUST00000246757.2 ENSMUSG00000121870 ENSMUST00000246757.2 ENSMUSG00000121870 (from geneSymbol) AK076883 ENSMUST00000246757.1 uc316rli.1 uc316rli.2 uc316rli.1 uc316rli.2 
ENSMUST00000246758.2 Gm57042 ENSMUST00000246758.2 Gm57042 (from geneSymbol) ENSMUST00000246758.1 uc316rlj.1 uc316rlj.2 uc316rlj.1 uc316rlj.2 
ENSMUST00000246761.1 Gm56590 ENSMUST00000246761.1 Gm56590 (from geneSymbol) uc316rlm.1 uc316rlm.1 
ENSMUST00000246764.2 Gm56670 ENSMUST00000246764.2 Gm56670 (from geneSymbol) ENSMUST00000246764.1 uc316rlp.1 uc316rlp.2 uc316rlp.1 uc316rlp.2 
ENSMUST00000246767.1 Gm57006 ENSMUST00000246767.1 Gm57006 (from geneSymbol) AK140940 uc316rls.1 uc316rls.1 
ENSMUST00000246773.2 Gm57383 ENSMUST00000246773.2 Gm57383 (from geneSymbol) ENSMUST00000246773.1 LF203076 uc316rly.1 uc316rly.2 uc316rly.1 uc316rly.2 
ENSMUST00000246774.2 Gm57235 ENSMUST00000246774.2 Gm57235 (from geneSymbol) ENSMUST00000246774.1 uc316rlz.1 uc316rlz.2 uc316rlz.1 uc316rlz.2 
ENSMUST00000246785.1 Gm56628 ENSMUST00000246785.1 Gm56628 (from geneSymbol) uc316rmk.1 uc316rmk.1 
ENSMUST00000246791.2 Gm57126 ENSMUST00000246791.2 Gm57126 (from geneSymbol) ENSMUST00000246791.1 uc316rmq.1 uc316rmq.2 uc316rmq.1 uc316rmq.2 
ENSMUST00000246796.1 Gm57043 ENSMUST00000246796.1 Gm57043 (from geneSymbol) uc316rmv.1 uc316rmv.1 
ENSMUST00000246797.2 Gm57384 ENSMUST00000246797.2 Gm57384 (from geneSymbol) ENSMUST00000246797.1 LF198999 uc316rmw.1 uc316rmw.2 uc316rmw.1 uc316rmw.2 
ENSMUST00000246798.2 Gm56548 ENSMUST00000246798.2 Gm56548 (from geneSymbol) AK144341 ENSMUST00000246798.1 uc316rmx.1 uc316rmx.2 uc316rmx.1 uc316rmx.2 
ENSMUST00000246800.1 1700028E11Rik ENSMUST00000246800.1 1700028E11Rik (from geneSymbol) BC048555 uc316rmz.1 uc316rmz.1 
ENSMUST00000246802.1 Gm51425 ENSMUST00000246802.1 Gm51425 (from geneSymbol) BC018101 uc316rnb.1 uc316rnb.1 
ENSMUST00000246808.2 Gm56817 ENSMUST00000246808.2 Gm56817 (from geneSymbol) ENSMUST00000246808.1 uc316rnh.1 uc316rnh.2 uc316rnh.1 uc316rnh.2 
ENSMUST00000246815.2 Gm33994 ENSMUST00000246815.2 Gm33994 (from geneSymbol) AK137777 ENSMUST00000246815.1 uc316rno.1 uc316rno.2 uc316rno.1 uc316rno.2 
ENSMUST00000246816.2 Gm56900 ENSMUST00000246816.2 Gm56900 (from geneSymbol) ENSMUST00000246816.1 uc316rnp.1 uc316rnp.2 uc316rnp.1 uc316rnp.2 
ENSMUST00000246823.2 Gm56973 ENSMUST00000246823.2 Gm56973 (from geneSymbol) ENSMUST00000246823.1 uc316rnw.1 uc316rnw.2 uc316rnw.1 uc316rnw.2 
ENSMUST00000246825.2 Gm57160 ENSMUST00000246825.2 Gm57160 (from geneSymbol) ENSMUST00000246825.1 uc316rny.1 uc316rny.2 uc316rny.1 uc316rny.2 
ENSMUST00000246831.2 Gm57302 ENSMUST00000246831.2 Gm57302 (from geneSymbol) ENSMUST00000246831.1 uc316roe.1 uc316roe.2 uc316roe.1 uc316roe.2 
ENSMUST00000246832.1 Gm56769 ENSMUST00000246832.1 Gm56769 (from geneSymbol) uc316rof.1 uc316rof.1 
ENSMUST00000246843.1 Gm56689 ENSMUST00000246843.1 Gm56689 (from geneSymbol) uc316roq.1 uc316roq.1 
ENSMUST00000246849.1 Gm56858 ENSMUST00000246849.1 Gm56858 (from geneSymbol) uc316row.1 uc316row.1 
ENSMUST00000246862.2 Gm27234 ENSMUST00000246862.2 Gm27234 (from geneSymbol) ENSMUST00000246862.1 uc316rpi.1 uc316rpi.2 uc316rpi.1 uc316rpi.2 
ENSMUST00000246865.1 Gm56770 ENSMUST00000246865.1 Gm56770 (from geneSymbol) uc316rpl.1 uc316rpl.1 
ENSMUST00000246866.1 Gm56721 ENSMUST00000246866.1 Gm56721 (from geneSymbol) LF200515 uc316rpm.1 uc316rpm.1 
ENSMUST00000246877.1 C430039J16Rik ENSMUST00000246877.1 C430039J16Rik (from geneSymbol) uc316rpx.1 uc316rpx.1 
ENSMUST00000246879.2 C530020B09Rik ENSMUST00000246879.2 C530020B09Rik (from geneSymbol) AK049667 ENSMUST00000246879.1 uc316rpz.1 uc316rpz.2 uc316rpz.1 uc316rpz.2 
ENSMUST00000246884.2 Gm57163 ENSMUST00000246884.2 Gm57163 (from geneSymbol) ENSMUST00000246884.1 uc316rqe.1 uc316rqe.2 uc316rqe.1 uc316rqe.2 
ENSMUST00000246885.2 Gm56859 ENSMUST00000246885.2 Gm56859 (from geneSymbol) ENSMUST00000246885.1 uc316rqf.1 uc316rqf.2 uc316rqf.1 uc316rqf.2 
ENSMUST00000246887.1 Gm12519 ENSMUST00000246887.1 Gm12519 (from geneSymbol) uc316rqh.1 uc316rqh.1 
ENSMUST00000246892.2 Gm39193 ENSMUST00000246892.2 predicted gene, 39193 (from RefSeq NR_176656.1) ENSMUST00000246892.1 NR_176656 uc316rqm.1 uc316rqm.2 uc316rqm.1 uc316rqm.2 
ENSMUST00000246907.1 Gm57220 ENSMUST00000246907.1 Gm57220 (from geneSymbol) uc316rrb.1 uc316rrb.1 
ENSMUST00000246908.2 Gm57164 ENSMUST00000246908.2 Gm57164 (from geneSymbol) ENSMUST00000246908.1 uc316rrc.1 uc316rrc.2 uc316rrc.1 uc316rrc.2 
ENSMUST00000246909.2 Gm57166 ENSMUST00000246909.2 Gm57166 (from geneSymbol) AB339726 ENSMUST00000246909.1 uc316rrd.1 uc316rrd.2 uc316rrd.1 uc316rrd.2 
ENSMUST00000246911.2 Gm56673 ENSMUST00000246911.2 Gm56673 (from geneSymbol) ENSMUST00000246911.1 LF201754 uc316rrf.1 uc316rrf.2 uc316rrf.1 uc316rrf.2 
ENSMUST00000246919.2 Gm38204 ENSMUST00000246919.2 Gm38204 (from geneSymbol) AK154426 ENSMUST00000246919.1 uc316rrn.1 uc316rrn.2 uc316rrn.1 uc316rrn.2 
ENSMUST00000246923.1 Gm36185 ENSMUST00000246923.1 Gm36185 (from geneSymbol) uc316rrr.1 uc316rrr.1 
ENSMUST00000246927.2 Gm57001 ENSMUST00000246927.2 Gm57001 (from geneSymbol) ENSMUST00000246927.1 uc316rru.1 uc316rru.2 uc316rru.1 uc316rru.2 
ENSMUST00000246938.2 Gm56629 ENSMUST00000246938.2 Gm56629 (from geneSymbol) ENSMUST00000246938.1 uc316rsf.1 uc316rsf.2 uc316rsf.1 uc316rsf.2 
ENSMUST00000246945.2 Gm57133 ENSMUST00000246945.2 Gm57133 (from geneSymbol) ENSMUST00000246945.1 uc316rsm.1 uc316rsm.2 uc316rsm.1 uc316rsm.2 
ENSMUST00000246953.1 Gm56976 ENSMUST00000246953.1 Gm56976 (from geneSymbol) uc316rss.1 uc316rss.1 
ENSMUST00000246954.2 Gm40372 ENSMUST00000246954.2 Gm40372 (from geneSymbol) ENSMUST00000246954.1 uc316rst.1 uc316rst.2 uc316rst.1 uc316rst.2 
ENSMUST00000246959.2 Gm30431 ENSMUST00000246959.2 Gm30431 (from geneSymbol) ENSMUST00000246959.1 uc316rsy.1 uc316rsy.2 uc316rsy.1 uc316rsy.2 
ENSMUST00000246961.2 Gm40124 ENSMUST00000246961.2 Gm40124 (from geneSymbol) ENSMUST00000246961.1 uc316rta.1 uc316rta.2 uc316rta.1 uc316rta.2 
ENSMUST00000246971.1 Gm57186 ENSMUST00000246971.1 Gm57186 (from geneSymbol) LF193052 uc316rtk.1 uc316rtk.1 
ENSMUST00000246973.2 Gm57169 ENSMUST00000246973.2 Gm57169 (from geneSymbol) AB334961 ENSMUST00000246973.1 uc316rtl.1 uc316rtl.2 uc316rtl.1 uc316rtl.2 
ENSMUST00000246975.1 Gm56725 ENSMUST00000246975.1 Gm56725 (from geneSymbol) uc316rtn.1 uc316rtn.1 
ENSMUST00000246980.1 Gm57221 ENSMUST00000246980.1 Gm57221 (from geneSymbol) AB349252 uc316rts.1 uc316rts.1 
ENSMUST00000246992.1 Gm57047 ENSMUST00000246992.1 Gm57047 (from geneSymbol) uc316ruc.1 uc316ruc.1 
ENSMUST00000247007.2 C030010C08Rik ENSMUST00000247007.2 C030010C08Rik (from geneSymbol) ENSMUST00000247007.1 LF199589 uc316ruq.1 uc316ruq.2 uc316ruq.1 uc316ruq.2 
ENSMUST00000247011.1 D17H6S56E-5 ENSMUST00000247011.1 D17H6S56E-5 (from geneSymbol) L78788 uc316ruu.1 uc316ruu.1 
ENSMUST00000247012.2 Gm56674 ENSMUST00000247012.2 Gm56674 (from geneSymbol) ENSMUST00000247012.1 uc316ruv.1 uc316ruv.2 uc316ruv.1 uc316ruv.2 
ENSMUST00000247013.2 Gm13421 ENSMUST00000247013.2 Gm13421 (from geneSymbol) AK146841 ENSMUST00000247013.1 uc316ruw.1 uc316ruw.2 uc316ruw.1 uc316ruw.2 
ENSMUST00000247019.2 Gm56977 ENSMUST00000247019.2 Gm56977 (from geneSymbol) ENSMUST00000247019.1 uc316rvc.1 uc316rvc.2 uc316rvc.1 uc316rvc.2 
ENSMUST00000247020.2 Gm54310 ENSMUST00000247020.2 Gm54310 (from geneSymbol) ENSMUST00000247020.1 uc316rvd.1 uc316rvd.2 uc316rvd.1 uc316rvd.2 
ENSMUST00000247025.1 Gm57137 ENSMUST00000247025.1 Gm57137 (from geneSymbol) uc316rvi.1 uc316rvi.1 
ENSMUST00000247029.2 Gm56738 ENSMUST00000247029.2 Gm56738 (from geneSymbol) DQ706562 ENSMUST00000247029.1 uc316rvm.1 uc316rvm.2 uc316rvm.1 uc316rvm.2 
ENSMUST00000247030.2 Gm32702 ENSMUST00000247030.2 Gm32702 (from geneSymbol) ENSMUST00000247030.1 uc316rvn.1 uc316rvn.2 uc316rvn.1 uc316rvn.2 
ENSMUST00000247034.1 Gm57008 ENSMUST00000247034.1 Gm57008 (from geneSymbol) LF198196 uc316rvq.1 uc316rvq.1 
ENSMUST00000247036.1 Gm57224 ENSMUST00000247036.1 Gm57224 (from geneSymbol) uc316rvs.1 uc316rvs.1 
ENSMUST00000247044.1 B230369F24Rik ENSMUST00000247044.1 B230369F24Rik (from geneSymbol) AK046316 uc316rwa.1 uc316rwa.1 
ENSMUST00000247047.2 Gm57387 ENSMUST00000247047.2 Gm57387 (from geneSymbol) ENSMUST00000247047.1 uc316rwd.1 uc316rwd.2 uc316rwd.1 uc316rwd.2 
ENSMUST00000247056.1 Gm57402 ENSMUST00000247056.1 Gm57402 (from geneSymbol) AK142278 uc316rwm.1 uc316rwm.1 
ENSMUST00000247060.1 Gm56901 ENSMUST00000247060.1 Gm56901 (from geneSymbol) uc316rwq.1 uc316rwq.1 
ENSMUST00000247062.2 Gm57050 ENSMUST00000247062.2 Gm57050 (from geneSymbol) ENSMUST00000247062.1 LF197811 uc316rws.1 uc316rws.2 uc316rws.1 uc316rws.2 
ENSMUST00000247067.2 Platr10 ENSMUST00000247067.2 Platr10 (from geneSymbol) AK010436 ENSMUST00000247067.1 uc316rwx.1 uc316rwx.2 uc316rwx.1 uc316rwx.2 
ENSMUST00000247071.2 Gm57170 ENSMUST00000247071.2 Gm57170 (from geneSymbol) ENSMUST00000247071.1 uc316rxb.1 uc316rxb.2 uc316rxb.1 uc316rxb.2 
ENSMUST00000247074.1 Gm56553 ENSMUST00000247074.1 Gm56553 (from geneSymbol) uc316rxe.1 uc316rxe.1 
ENSMUST00000247077.2 Gm57442 ENSMUST00000247077.2 Gm57442 (from geneSymbol) ENSMUST00000247077.1 uc316rxh.1 uc316rxh.2 uc316rxh.1 uc316rxh.2 
ENSMUST00000247078.2 Gm56727 ENSMUST00000247078.2 Gm56727 (from geneSymbol) ENSMUST00000247078.1 uc316rxi.1 uc316rxi.2 uc316rxi.1 uc316rxi.2 
ENSMUST00000247080.1 Gm56818 ENSMUST00000247080.1 Gm56818 (from geneSymbol) uc316rxk.1 uc316rxk.1 
ENSMUST00000247081.2 Gm56979 ENSMUST00000247081.2 Gm56979 (from geneSymbol) ENSMUST00000247081.1 uc316rxl.1 uc316rxl.2 uc316rxl.1 uc316rxl.2 
ENSMUST00000247083.2 Gm57389 ENSMUST00000247083.2 Gm57389 (from geneSymbol) ENSMUST00000247083.1 uc316rxn.1 uc316rxn.2 uc316rxn.1 uc316rxn.2 
ENSMUST00000247085.1 Gm57228 ENSMUST00000247085.1 Gm57228 (from geneSymbol) LF202771 uc316rxp.1 uc316rxp.1 
ENSMUST00000247086.1 Gm57051 ENSMUST00000247086.1 Gm57051 (from geneSymbol) uc316rxq.1 uc316rxq.1 
ENSMUST00000247088.1 5730424H11Rik ENSMUST00000247088.1 5730424H11Rik (from geneSymbol) DQ714368 uc316rxs.1 uc316rxs.1 
ENSMUST00000247089.2 4930423K06Rik ENSMUST00000247089.2 4930423K06Rik (from geneSymbol) ENSMUST00000247089.1 LF200437 uc316rxt.1 uc316rxt.2 uc316rxt.1 uc316rxt.2 
ENSMUST00000247090.2 Gm56860 ENSMUST00000247090.2 Gm56860 (from geneSymbol) ENSMUST00000247090.1 uc316rxu.1 uc316rxu.2 uc316rxu.1 uc316rxu.2 
ENSMUST00000247091.2 Gm56980 ENSMUST00000247091.2 Gm56980 (from geneSymbol) ENSMUST00000247091.1 uc316rxv.1 uc316rxv.2 uc316rxv.1 uc316rxv.2 
ENSMUST00000247092.2 Gm6403 ENSMUST00000247092.2 Gm6403 (from geneSymbol) ENSMUST00000247092.1 LF193107 uc316rxw.1 uc316rxw.2 uc316rxw.1 uc316rxw.2 
ENSMUST00000247098.2 Gm57138 ENSMUST00000247098.2 Gm57138 (from geneSymbol) ENSMUST00000247098.1 uc316ryc.1 uc316ryc.2 uc316ryc.1 uc316ryc.2 
ENSMUST00000247099.2 Gm57052 ENSMUST00000247099.2 Gm57052 (from geneSymbol) ENSMUST00000247099.1 uc316ryd.1 uc316ryd.2 uc316ryd.1 uc316ryd.2 
ENSMUST00000247101.2 Gm57226 ENSMUST00000247101.2 Gm57226 (from geneSymbol) ENSMUST00000247101.1 uc316ryf.1 uc316ryf.2 uc316ryf.1 uc316ryf.2 
ENSMUST00000247102.1 2900079G21Rik ENSMUST00000247102.1 2900079G21Rik (from geneSymbol) AK047318 uc316ryg.1 uc316ryg.1 
ENSMUST00000247103.2 Gm56861 ENSMUST00000247103.2 Gm56861 (from geneSymbol) ENSMUST00000247103.1 uc316ryh.1 uc316ryh.2 uc316ryh.1 uc316ryh.2 
ENSMUST00000247104.1 Gm56862 ENSMUST00000247104.1 Gm56862 (from geneSymbol) AK002673 uc316ryi.1 uc316ryi.1 
ENSMUST00000247107.1 Gm57443 ENSMUST00000247107.1 Gm57443 (from geneSymbol) uc316ryl.1 uc316ryl.1 
ENSMUST00000247115.2 Gm57390 ENSMUST00000247115.2 Gm57390 (from geneSymbol) ENSMUST00000247115.1 LF198856 uc316ryt.1 uc316ryt.2 uc316ryt.1 uc316ryt.2 
ENSMUST00000247122.2 Gm57002 ENSMUST00000247122.2 Gm57002 (from geneSymbol) ENSMUST00000247122.1 LF195790 uc316rza.1 uc316rza.2 uc316rza.1 uc316rza.2 
ENSMUST00000247125.1 Gm56863 ENSMUST00000247125.1 Gm56863 (from geneSymbol) uc316rzd.1 uc316rzd.1 
ENSMUST00000247127.2 Gm57317 ENSMUST00000247127.2 Gm57317 (from geneSymbol) ENSMUST00000247127.1 LF194898 uc316rzf.1 uc316rzf.2 uc316rzf.1 uc316rzf.2 
ENSMUST00000247128.2 Gm57311 ENSMUST00000247128.2 Gm57311 (from geneSymbol) ENSMUST00000247128.1 uc316rzg.1 uc316rzg.2 uc316rzg.1 uc316rzg.2 
ENSMUST00000247131.2 Gm57391 ENSMUST00000247131.2 Gm57391 (from geneSymbol) ENSMUST00000247131.1 uc316rzj.1 uc316rzj.2 uc316rzj.1 uc316rzj.2 
ENSMUST00000247135.2 Gm34854 ENSMUST00000247135.2 Gm34854 (from geneSymbol) ENSMUST00000247135.1 uc316rzn.1 uc316rzn.2 uc316rzn.1 uc316rzn.2 
ENSMUST00000247136.2 Gm56819 ENSMUST00000247136.2 Gm56819 (from geneSymbol) ENSMUST00000247136.1 uc316rzo.1 uc316rzo.2 uc316rzo.1 uc316rzo.2 
ENSMUST00000247143.2 Gm56903 ENSMUST00000247143.2 Gm56903 (from geneSymbol) ENSMUST00000247143.1 uc316rzv.1 uc316rzv.2 uc316rzv.1 uc316rzv.2 
ENSMUST00000247147.2 Gm57053 ENSMUST00000247147.2 Gm57053 (from geneSymbol) ENSMUST00000247147.1 uc316rzz.1 uc316rzz.2 uc316rzz.1 uc316rzz.2 
ENSMUST00000247149.2 Gm57397 ENSMUST00000247149.2 Gm57397 (from geneSymbol) AK083508 ENSMUST00000247149.1 uc316sab.1 uc316sab.2 uc316sab.1 uc316sab.2 
ENSMUST00000247160.2 Gm50020 ENSMUST00000247160.2 Gm50020 (from geneSymbol) ENSMUST00000247160.1 uc316sam.1 uc316sam.2 uc316sam.1 uc316sam.2 
ENSMUST00000247162.1 9330133O14Rik ENSMUST00000247162.1 RIKEN cDNA 9330133O14 gene (from RefSeq NR_045696.1) NR_045696 uc316sao.1 uc316sao.1 
ENSMUST00000247165.2 A930016O22Rik ENSMUST00000247165.2 A930016O22Rik (from geneSymbol) AK046115 ENSMUST00000247165.1 uc316sar.1 uc316sar.2 uc316sar.1 uc316sar.2 
ENSMUST00000247177.2 Gm56729 ENSMUST00000247177.2 Gm56729 (from geneSymbol) ENSMUST00000247177.1 uc316sbc.1 uc316sbc.2 uc316sbc.1 uc316sbc.2 
ENSMUST00000247192.1 Gm11767 ENSMUST00000247192.1 Gm11767 (from geneSymbol) KY467623 uc316sbr.1 uc316sbr.1 
ENSMUST00000247197.2 Gm56731 ENSMUST00000247197.2 Gm56731 (from geneSymbol) ENSMUST00000247197.1 uc316sbw.1 uc316sbw.2 uc316sbw.1 uc316sbw.2 
ENSMUST00000247199.2 Gm56734 ENSMUST00000247199.2 Gm56734 (from geneSymbol) AK036498 ENSMUST00000247199.1 uc316sby.1 uc316sby.2 uc316sby.1 uc316sby.2 
ENSMUST00000247205.2 Gm57313 ENSMUST00000247205.2 Gm57313 (from geneSymbol) ENSMUST00000247205.1 uc316sce.1 uc316sce.2 uc316sce.1 uc316sce.2 
ENSMUST00000247209.2 Gm57392 ENSMUST00000247209.2 Gm57392 (from geneSymbol) ENSMUST00000247209.1 uc316sci.1 uc316sci.2 uc316sci.1 uc316sci.2 
ENSMUST00000247212.2 Gm57056 ENSMUST00000247212.2 Gm57056 (from geneSymbol) AK015717 ENSMUST00000247212.1 uc316scl.1 uc316scl.2 uc316scl.1 uc316scl.2 
ENSMUST00000247217.1 4732440D04Rik ENSMUST00000247217.1 4732440D04Rik (from geneSymbol) uc316scq.1 uc316scq.1 
ENSMUST00000247225.2 Gm57057 ENSMUST00000247225.2 Gm57057 (from geneSymbol) ENSMUST00000247225.1 uc316scy.1 uc316scy.2 uc316scy.1 uc316scy.2 
ENSMUST00000247229.2 Pramel13os ENSMUST00000247229.2 Pramel13os (from geneSymbol) AK021319 ENSMUST00000247229.1 uc316sdc.1 uc316sdc.2 uc316sdc.1 uc316sdc.2 
ENSMUST00000247231.1 Gm57231 ENSMUST00000247231.1 Gm57231 (from geneSymbol) uc316sde.1 uc316sde.1 
ENSMUST00000247233.1 Gm53771 ENSMUST00000247233.1 Gm53771 (from geneSymbol) uc316sdg.1 uc316sdg.1 
ENSMUST00000247236.2 4933416M07Rik ENSMUST00000247236.2 RIKEN cDNA 4933416M07 gene (from RefSeq NR_045840.1) ENSMUST00000247236.1 NR_045840 uc316sdj.1 uc316sdj.2 uc316sdj.1 uc316sdj.2 
ENSMUST00000247237.2 Gm56865 ENSMUST00000247237.2 Gm56865 (from geneSymbol) ENSMUST00000247237.1 uc316sdk.1 uc316sdk.2 uc316sdk.1 uc316sdk.2 
ENSMUST00000247239.1 Ttc39aos1 ENSMUST00000247239.1 Ttc39a opposite strand RNA 1 (from RefSeq NR_131195.1) NR_131195 uc316sdm.1 uc316sdm.1 
ENSMUST00000247241.2 Gm57446 ENSMUST00000247241.2 Gm57446 (from geneSymbol) ENSMUST00000247241.1 LF193370 uc316sdo.1 uc316sdo.2 uc316sdo.1 uc316sdo.2 
ENSMUST00000247245.1 Hmga2-ps1 ENSMUST00000247245.1 high mobility group AT-hook 2, pseudogene 1 (from RefSeq NR_037996.1) NR_037996 uc316sds.1 uc316sds.1 
ENSMUST00000247248.2 Gm57151 ENSMUST00000247248.2 Gm57151 (from geneSymbol) ENSMUST00000247248.1 uc316sdv.1 uc316sdv.2 uc316sdv.1 uc316sdv.2 
ENSMUST00000247256.2 4921531C22Rik ENSMUST00000247256.2 4921531C22Rik (from geneSymbol) ENSMUST00000247256.1 uc316sed.1 uc316sed.2 uc316sed.1 uc316sed.2 
ENSMUST00000247258.1 Gm56984 ENSMUST00000247258.1 Gm56984 (from geneSymbol) uc316sef.1 uc316sef.1 
ENSMUST00000247259.2 Gm56866 ENSMUST00000247259.2 Gm56866 (from geneSymbol) ENSMUST00000247259.1 uc316seg.1 uc316seg.2 uc316seg.1 uc316seg.2 
ENSMUST00000247267.1 Gm57232 ENSMUST00000247267.1 Gm57232 (from geneSymbol) uc316seo.1 uc316seo.1 
ENSMUST00000247268.1 Gm56878 ENSMUST00000247268.1 Gm56878 (from geneSymbol) uc316sep.1 uc316sep.1 
ENSMUST00000247281.1 Gm56733 ENSMUST00000247281.1 Gm56733 (from geneSymbol) uc316sfc.1 uc316sfc.1 
ENSMUST00000247282.1 Gm57233 ENSMUST00000247282.1 Gm57233 (from geneSymbol) uc316sfd.1 uc316sfd.1 
ENSMUST00000247285.2 Gm57316 ENSMUST00000247285.2 Gm57316 (from geneSymbol) ENSMUST00000247285.1 uc316sfg.1 uc316sfg.2 uc316sfg.1 uc316sfg.2 
ENSMUST00000247287.2 Gm17586 ENSMUST00000247287.2 Gm17586 (from geneSymbol) ENSMUST00000247287.1 uc316sfi.1 uc316sfi.2 uc316sfi.1 uc316sfi.2 
ENSMUST00000247288.2 Gm12827 ENSMUST00000247288.2 Gm12827 (from geneSymbol) ENSMUST00000247288.1 uc316sfj.1 uc316sfj.2 uc316sfj.1 uc316sfj.2 
ENSMUST00000247302.1 Gm56908 ENSMUST00000247302.1 Gm56908 (from geneSymbol) uc316sfx.1 uc316sfx.1 
ENSMUST00000247312.2 Gm57157 ENSMUST00000247312.2 Gm57157 (from geneSymbol) ENSMUST00000247312.1 LF194557 uc316sgh.1 uc316sgh.2 uc316sgh.1 uc316sgh.2 
ENSMUST00000247314.2 Gm56735 ENSMUST00000247314.2 Gm56735 (from geneSymbol) ENSMUST00000247314.1 uc316sgj.1 uc316sgj.2 uc316sgj.1 uc316sgj.2 
ENSMUST00000247317.1 Gm56909 ENSMUST00000247317.1 Gm56909 (from geneSymbol) AK143140 uc316sgm.1 uc316sgm.1 
ENSMUST00000247318.1 Gm56910 ENSMUST00000247318.1 Gm56910 (from geneSymbol) uc316sgn.1 uc316sgn.1 
ENSMUST00000247326.2 Gm57159 ENSMUST00000247326.2 Gm57159 (from geneSymbol) ENSMUST00000247326.1 uc316sgu.1 uc316sgu.2 uc316sgu.1 uc316sgu.2 
ENSMUST00000247328.1 Gm56869 ENSMUST00000247328.1 Gm56869 (from geneSymbol) uc316sgw.1 uc316sgw.1 
ENSMUST00000247333.2 9430021M05Rik ENSMUST00000247333.2 9430021M05Rik (from geneSymbol) AK079072 ENSMUST00000247333.1 uc316shb.1 uc316shb.2 uc316shb.1 uc316shb.2 
ENSMUST00000247334.2 Gm56870 ENSMUST00000247334.2 Gm56870 (from geneSymbol) ENSMUST00000247334.1 uc316shc.1 uc316shc.2 uc316shc.1 uc316shc.2 
ENSMUST00000247343.2 Gm31828 ENSMUST00000247343.2 Gm31828 (from geneSymbol) ENSMUST00000247343.1 KY467995 uc316shl.1 uc316shl.2 uc316shl.1 uc316shl.2 
ENSMUST00000247350.2 Gm56871 ENSMUST00000247350.2 Gm56871 (from geneSymbol) ENSMUST00000247350.1 uc316shr.1 uc316shr.2 uc316shr.1 uc316shr.2 
ENSMUST00000247353.2 Gm31249 ENSMUST00000247353.2 Gm31249 (from geneSymbol) ENSMUST00000247353.1 uc316shu.1 uc316shu.2 uc316shu.1 uc316shu.2 
ENSMUST00000247354.1 Gm35254 ENSMUST00000247354.1 Gm35254 (from geneSymbol) uc316shv.1 uc316shv.1 
ENSMUST00000247362.1 5430414B12Rik ENSMUST00000247362.1 5430414B12Rik (from geneSymbol) AK017306 uc316sid.1 uc316sid.1 
ENSMUST00000247366.2 Gm57415 ENSMUST00000247366.2 Gm57415 (from geneSymbol) ENSMUST00000247366.1 uc316sih.1 uc316sih.2 uc316sih.1 uc316sih.2 
ENSMUST00000247367.1 Gm57322 ENSMUST00000247367.1 Gm57322 (from geneSymbol) AY423052 uc316sii.1 uc316sii.1 
ENSMUST00000247373.2 Gm56988 ENSMUST00000247373.2 Gm56988 (from geneSymbol) ENSMUST00000247373.1 uc316sio.1 uc316sio.2 uc316sio.1 uc316sio.2 
ENSMUST00000247383.2 Gm57447 ENSMUST00000247383.2 Gm57447 (from geneSymbol) ENSMUST00000247383.1 uc316siy.1 uc316siy.2 uc316siy.1 uc316siy.2 
ENSMUST00000247385.2 Gm57448 ENSMUST00000247385.2 Gm57448 (from geneSymbol) ENSMUST00000247385.1 uc316sja.1 uc316sja.2 uc316sja.1 uc316sja.2 
ENSMUST00000247388.2 Gm9564 ENSMUST00000247388.2 Gm9564 (from geneSymbol) ENSMUST00000247388.1 uc316sjc.1 uc316sjc.2 uc316sjc.1 uc316sjc.2 
ENSMUST00000247391.2 Gm57325 ENSMUST00000247391.2 Gm57325 (from geneSymbol) ENSMUST00000247391.1 uc316sjf.1 uc316sjf.2 uc316sjf.1 uc316sjf.2 
ENSMUST00000247397.2 Gm56999 ENSMUST00000247397.2 Gm56999 (from geneSymbol) AF217545 ENSMUST00000247397.1 uc316sjl.1 uc316sjl.2 uc316sjl.1 uc316sjl.2 
ENSMUST00000247398.2 Gm56914 ENSMUST00000247398.2 Gm56914 (from geneSymbol) ENSMUST00000247398.1 uc316sjm.1 uc316sjm.2 uc316sjm.1 uc316sjm.2 
ENSMUST00000247399.2 Gm57171 ENSMUST00000247399.2 Gm57171 (from geneSymbol) ENSMUST00000247399.1 uc316sjn.1 uc316sjn.2 uc316sjn.1 uc316sjn.2 
ENSMUST00000247404.2 Gm12224 ENSMUST00000247404.2 Gm12224 (from geneSymbol) ENSMUST00000247404.1 uc316sjs.1 uc316sjs.2 uc316sjs.1 uc316sjs.2 
ENSMUST00000247405.1 Gm56739 ENSMUST00000247405.1 Gm56739 (from geneSymbol) uc316sjt.1 uc316sjt.1 
ENSMUST00000247406.2 Gm57237 ENSMUST00000247406.2 Gm57237 (from geneSymbol) ENSMUST00000247406.1 uc316sju.1 uc316sju.2 uc316sju.1 uc316sju.2 
ENSMUST00000247407.1 Gm57395 ENSMUST00000247407.1 Gm57395 (from geneSymbol) AK084103 uc316sjv.1 uc316sjv.1 
ENSMUST00000247408.2 Gm56740 ENSMUST00000247408.2 Gm56740 (from geneSymbol) ENSMUST00000247408.1 uc316sjw.1 uc316sjw.2 uc316sjw.1 uc316sjw.2 
ENSMUST00000247410.1 Gm57449 ENSMUST00000247410.1 Gm57449 (from geneSymbol) uc316sjy.1 uc316sjy.1 
ENSMUST00000247413.1 Gm56875 ENSMUST00000247413.1 Gm56875 (from geneSymbol) uc316skb.1 uc316skb.1 
ENSMUST00000247418.1 Gm56997 ENSMUST00000247418.1 Gm56997 (from geneSymbol) LF195994 uc316skg.1 uc316skg.1 
ENSMUST00000247423.2 Gm57399 ENSMUST00000247423.2 Gm57399 (from geneSymbol) ENSMUST00000247423.1 LF198744 uc316skl.1 uc316skl.2 uc316skl.1 uc316skl.2 
ENSMUST00000247424.2 Gm33934 ENSMUST00000247424.2 predicted gene, 33934 (from RefSeq NR_166918.1) ENSMUST00000247424.1 NR_166918 uc316skm.1 uc316skm.2 uc316skm.1 uc316skm.2 
ENSMUST00000247425.1 Gm57451 ENSMUST00000247425.1 Gm57451 (from geneSymbol) uc316skn.1 uc316skn.1 
ENSMUST00000247427.2 Gm56876 ENSMUST00000247427.2 Gm56876 (from geneSymbol) ENSMUST00000247427.1 LF197357 uc316skp.1 uc316skp.2 uc316skp.1 uc316skp.2 
ENSMUST00000247428.2 2810461L16Rik ENSMUST00000247428.2 2810461L16Rik (from geneSymbol) ENSMUST00000247428.1 uc316skq.1 uc316skq.2 uc316skq.1 uc316skq.2 
ENSMUST00000247431.1 Gm57454 ENSMUST00000247431.1 Gm57454 (from geneSymbol) uc316skt.1 uc316skt.1 
ENSMUST00000247432.2 Gm56742 ENSMUST00000247432.2 Gm56742 (from geneSymbol) ENSMUST00000247432.1 uc316sku.1 uc316sku.2 uc316sku.1 uc316sku.2 
ENSMUST00000247434.1 Gm57239 ENSMUST00000247434.1 Gm57239 (from geneSymbol) uc316skw.1 uc316skw.1 
ENSMUST00000247441.2 Gm57000 ENSMUST00000247441.2 Gm57000 (from geneSymbol) ENSMUST00000247441.1 LF195857 uc316slc.1 uc316slc.2 uc316slc.1 uc316slc.2 
ENSMUST00000247442.1 Gm32707 ENSMUST00000247442.1 Gm32707 (from geneSymbol) uc316sld.1 uc316sld.1 
ENSMUST00000247444.1 Gm56916 ENSMUST00000247444.1 Gm56916 (from geneSymbol) AK138794 uc316slf.1 uc316slf.1 
ENSMUST00000247448.2 Gm54112 ENSMUST00000247448.2 Gm54112 (from geneSymbol) ENSMUST00000247448.1 uc316slj.1 uc316slj.2 uc316slj.1 uc316slj.2 
ENSMUST00000247452.2 Gm57456 ENSMUST00000247452.2 Gm57456 (from geneSymbol) ENSMUST00000247452.1 uc316sln.1 uc316sln.2 uc316sln.1 uc316sln.2 
ENSMUST00000247453.1 Gm57242 ENSMUST00000247453.1 Gm57242 (from geneSymbol) uc316slo.1 uc316slo.1 
ENSMUST00000247458.2 Gm57244 ENSMUST00000247458.2 Gm57244 (from geneSymbol) ENSMUST00000247458.1 uc316slt.1 uc316slt.2 uc316slt.1 uc316slt.2 
ENSMUST00000247462.1 Gm57458 ENSMUST00000247462.1 Gm57458 (from geneSymbol) LF193273 uc316slx.1 uc316slx.1 
ENSMUST00000247465.2 Gm39606 ENSMUST00000247465.2 Gm39606 (from geneSymbol) ENSMUST00000247465.1 uc316sma.1 uc316sma.2 uc316sma.1 uc316sma.2 
ENSMUST00000247470.2 Gm53066 ENSMUST00000247470.2 predicted gene, 53066 (from RefSeq NR_170898.1) ENSMUST00000247470.1 NR_170898 uc316sme.1 uc316sme.2 uc316sme.1 uc316sme.2 
ENSMUST00000247474.1 Gm36279 ENSMUST00000247474.1 Gm36279 (from geneSymbol) uc316smi.1 uc316smi.1 
ENSMUST00000247483.2 Gm57464 ENSMUST00000247483.2 Gm57464 (from geneSymbol) ENSMUST00000247483.1 LF193475 uc316smr.1 uc316smr.2 uc316smr.1 uc316smr.2 
ENSMUST00000247485.2 Gm57476 ENSMUST00000247485.2 Gm57476 (from geneSymbol) ENSMUST00000247485.1 uc316smt.1 uc316smt.2 uc316smt.1 uc316smt.2 
ENSMUST00000247488.2 Gm57396 ENSMUST00000247488.2 Gm57396 (from geneSymbol) ENSMUST00000247488.1 uc316smw.1 uc316smw.2 uc316smw.1 uc316smw.2 
ENSMUST00000247495.1 Gm57247 ENSMUST00000247495.1 Gm57247 (from geneSymbol) uc316snd.1 uc316snd.1 
ENSMUST00000247497.1 Gm39103 ENSMUST00000247497.1 Gm39103 (from geneSymbol) uc316snf.1 uc316snf.1 
ENSMUST00000247501.1 Gm57248 ENSMUST00000247501.1 Gm57248 (from geneSymbol) uc316sni.1 uc316sni.1 
ENSMUST00000247505.2 Gm57172 ENSMUST00000247505.2 Gm57172 (from geneSymbol) AK013313 ENSMUST00000247505.1 uc316snm.1 uc316snm.2 uc316snm.1 uc316snm.2 
ENSMUST00000247507.2 C030014O09Rik ENSMUST00000247507.2 C030014O09Rik (from geneSymbol) ENSMUST00000247507.1 LF204170 uc316sno.1 uc316sno.2 uc316sno.1 uc316sno.2 
ENSMUST00000247510.1 Gm57457 ENSMUST00000247510.1 Gm57457 (from geneSymbol) AK013066 uc316snr.1 uc316snr.1 
ENSMUST00000247513.1 6720407P12Rik ENSMUST00000247513.1 6720407P12Rik (from geneSymbol) LF198618 uc316snu.1 uc316snu.1 
ENSMUST00000247515.2 Gm56918 ENSMUST00000247515.2 Gm56918 (from geneSymbol) ENSMUST00000247515.1 uc316snw.1 uc316snw.2 uc316snw.1 uc316snw.2 
ENSMUST00000247520.1 Gm56920 ENSMUST00000247520.1 Gm56920 (from geneSymbol) uc316sob.1 uc316sob.1 
ENSMUST00000247523.1 Gm56921 ENSMUST00000247523.1 Gm56921 (from geneSymbol) uc316soe.1 uc316soe.1 
ENSMUST00000247525.2 Gm53374 ENSMUST00000247525.2 Gm53374 (from geneSymbol) ENSMUST00000247525.1 uc316sog.1 uc316sog.2 uc316sog.1 uc316sog.2 
ENSMUST00000247528.1 Gm15545 ENSMUST00000247528.1 Gm15545 (from geneSymbol) AK087248 uc316soj.1 uc316soj.1 
ENSMUST00000247530.2 Gm57250 ENSMUST00000247530.2 Gm57250 (from geneSymbol) ENSMUST00000247530.1 uc316sol.1 uc316sol.2 uc316sol.1 uc316sol.2 
ENSMUST00000247539.2 Gm57251 ENSMUST00000247539.2 Gm57251 (from geneSymbol) ENSMUST00000247539.1 uc316sot.1 uc316sot.2 uc316sot.1 uc316sot.2 
ENSMUST00000247540.2 Gm56922 ENSMUST00000247540.2 Gm56922 (from geneSymbol) ENSMUST00000247540.1 uc316sou.1 uc316sou.2 uc316sou.1 uc316sou.2 
ENSMUST00000247541.1 Gm41608 ENSMUST00000247541.1 Gm41608 (from geneSymbol) uc316sov.1 uc316sov.1 
ENSMUST00000247544.2 Gm57252 ENSMUST00000247544.2 Gm57252 (from geneSymbol) AK198912 ENSMUST00000247544.1 uc316sox.1 uc316sox.2 uc316sox.1 uc316sox.2 
ENSMUST00000247546.2 Gm57463 ENSMUST00000247546.2 Gm57463 (from geneSymbol) ENSMUST00000247546.1 uc316soz.1 uc316soz.2 uc316soz.1 uc316soz.2 
ENSMUST00000247551.2 Stk35os1 ENSMUST00000247551.2 Stk35os1 (from geneSymbol) ENSMUST00000247551.1 LF193582 uc316spe.1 uc316spe.2 uc316spe.1 uc316spe.2 
ENSMUST00000247555.2 Gm57475 ENSMUST00000247555.2 Gm57475 (from geneSymbol) ENSMUST00000247555.1 LF193188 uc316spi.1 uc316spi.2 uc316spi.1 uc316spi.2 
ENSMUST00000247556.1 Gm12002 ENSMUST00000247556.1 Gm12002 (from geneSymbol) AK040873 uc316spj.1 uc316spj.1 
ENSMUST00000247557.2 Gm57173 ENSMUST00000247557.2 Gm57173 (from geneSymbol) ENSMUST00000247557.1 uc316spk.1 uc316spk.2 uc316spk.1 uc316spk.2 
ENSMUST00000247561.1 A930015D03Rik ENSMUST00000247561.1 A930015D03Rik (from geneSymbol) AK078380 uc316spo.1 uc316spo.1 
ENSMUST00000247562.1 Gm33841 ENSMUST00000247562.1 Gm33841 (from geneSymbol) uc316spp.1 uc316spp.1 
ENSMUST00000247563.2 Gm56923 ENSMUST00000247563.2 Gm56923 (from geneSymbol) AB350163 ENSMUST00000247563.1 uc316spq.1 uc316spq.2 uc316spq.1 uc316spq.2 
ENSMUST00000247567.2 Gm57401 ENSMUST00000247567.2 Gm57401 (from geneSymbol) ENSMUST00000247567.1 uc316spu.1 uc316spu.2 uc316spu.1 uc316spu.2 
ENSMUST00000247568.2 Gm57405 ENSMUST00000247568.2 Gm57405 (from geneSymbol) ENSMUST00000247568.1 uc316spv.1 uc316spv.2 uc316spv.1 uc316spv.2 
ENSMUST00000247593.2 Gm57459 ENSMUST00000247593.2 Gm57459 (from geneSymbol) ENSMUST00000247593.1 uc316sqs.1 uc316sqs.2 uc316sqs.1 uc316sqs.2 
ENSMUST00000247594.1 Gm57407 ENSMUST00000247594.1 Gm57407 (from geneSymbol) uc316sqt.1 uc316sqt.1 
ENSMUST00000247602.1 Gm57462 ENSMUST00000247602.1 Gm57462 (from geneSymbol) uc316srb.1 uc316srb.1 
ENSMUST00000247604.2 D030016M11Rik ENSMUST00000247604.2 D030016M11Rik (from geneSymbol) ENSMUST00000247604.1 LF198374 uc316src.1 uc316src.2 uc316src.1 uc316src.2 
ENSMUST00000247607.1 Gm57410 ENSMUST00000247607.1 Gm57410 (from geneSymbol) uc316srf.1 uc316srf.1 
ENSMUST00000247620.2 Gm57468 ENSMUST00000247620.2 Gm57468 (from geneSymbol) ENSMUST00000247620.1 uc316srs.1 uc316srs.2 uc316srs.1 uc316srs.2 
ENSMUST00000247622.2 Gm57175 ENSMUST00000247622.2 Gm57175 (from geneSymbol) ENSMUST00000247622.1 LF202342 uc316sru.1 uc316sru.2 uc316sru.1 uc316sru.2 
ENSMUST00000247624.2 Gm27003 ENSMUST00000247624.2 Gm27003 (from geneSymbol) ENSMUST00000247624.1 uc316srw.1 uc316srw.2 uc316srw.1 uc316srw.2 
ENSMUST00000247630.2 Gm57474 ENSMUST00000247630.2 Gm57474 (from geneSymbol) ENSMUST00000247630.1 uc316ssc.1 uc316ssc.2 uc316ssc.1 uc316ssc.2 
ENSMUST00000247631.2 Gm29260 ENSMUST00000247631.2 Gm29260 (from geneSymbol) ENSMUST00000247631.1 uc316ssd.1 uc316ssd.2 uc316ssd.1 uc316ssd.2 
ENSMUST00000247636.2 Gm57465 ENSMUST00000247636.2 Gm57465 (from geneSymbol) ENSMUST00000247636.1 LF193277 uc316ssi.1 uc316ssi.2 uc316ssi.1 uc316ssi.2 
ENSMUST00000247641.2 Gm57467 ENSMUST00000247641.2 Gm57467 (from geneSymbol) ENSMUST00000247641.1 uc316ssn.1 uc316ssn.2 uc316ssn.1 uc316ssn.2 
ENSMUST00000247645.2 Gm57469 ENSMUST00000247645.2 Gm57469 (from geneSymbol) ENSMUST00000247645.1 uc316ssq.1 uc316ssq.2 uc316ssq.1 uc316ssq.2 
ENSMUST00000247652.1 Gm57470 ENSMUST00000247652.1 Gm57470 (from geneSymbol) uc316ssw.1 uc316ssw.1 
ENSMUST00000247655.2 Gm57471 ENSMUST00000247655.2 Gm57471 (from geneSymbol) ENSMUST00000247655.1 uc316ssz.1 uc316ssz.2 uc316ssz.1 uc316ssz.2 
ENSMUST00000247659.1 Gm57176 ENSMUST00000247659.1 Gm57176 (from geneSymbol) uc316std.1 uc316std.1 
ENSMUST00000247663.1 Gm57472 ENSMUST00000247663.1 Gm57472 (from geneSymbol) uc316sth.1 uc316sth.1 
ENSMUST00000247665.2 Gm57473 ENSMUST00000247665.2 Gm57473 (from geneSymbol) ENSMUST00000247665.1 uc316stj.1 uc316stj.2 uc316stj.1 uc316stj.2 
ENSMUST00000247675.2 Gm57477 ENSMUST00000247675.2 Gm57477 (from geneSymbol) ENSMUST00000247675.1 uc316stt.1 uc316stt.2 uc316stt.1 uc316stt.2 
ENSMUST00000247684.1 Gm57177 ENSMUST00000247684.1 Gm57177 (from geneSymbol) uc316sub.1 uc316sub.1 
ENSMUST00000247690.1 Gm41914 ENSMUST00000247690.1 Gm41914 (from geneSymbol) uc316suh.1 uc316suh.1 
ENSMUST00000247692.2 Gm57179 ENSMUST00000247692.2 Gm57179 (from geneSymbol) ENSMUST00000247692.1 uc316suj.1 uc316suj.2 uc316suj.1 uc316suj.2 
ENSMUST00000247721.1 Snhg6 ENSMUST00000247721.1 Snhg6 (from geneSymbol) AK003573 uc316svl.1 uc316svl.1 
ENSMUST00000247726.2 Gm57187 ENSMUST00000247726.2 Gm57187 (from geneSymbol) ENSMUST00000247726.1 uc316svq.1 uc316svq.2 uc316svq.1 uc316svq.2 
ENSMUST00000247727.2 Gm57188 ENSMUST00000247727.2 Gm57188 (from geneSymbol) ENSMUST00000247727.1 uc316svr.1 uc316svr.2 uc316svr.1 uc316svr.2 
ENSMUST00000247730.1 Gm57189 ENSMUST00000247730.1 Gm57189 (from geneSymbol) LF192697 uc316svu.1 uc316svu.1 
ENSMUST00000247846.1 Ccdc8 ENSMUST00000247846.1 Ccdc8 (from geneSymbol) A0A991EPJ6 A0A991EPJ6_MOUSE Ccdc8 uc316vrj.1 uc316vrj.1 
ENSMUST00000247848.1 H1f10 ENSMUST00000247848.1 Nucleus (from UniProt A0A991ENW0) A0A991ENW0 A0A991ENW0_MOUSE H1f10 LF195683 uc316vrl.1 Nucleus Belongs to the histone H1/H5 family. uc316vrl.1 
ENSMUST00000248501.2 Btg1c ENSMUST00000248501.2 Btg1c (from geneSymbol) AK132831 ENSMUST00000248501.1 uc316vrt.1 uc316vrt.2 uc316vrt.1 uc316vrt.2 
ENSMUST00000248537.1 Ptprg ENSMUST00000248537.1 protein tyrosine phosphatase receptor type G, transcript variant 1 (from RefSeq NM_008981.3) A0A991ELE1 A0A991ELE1_MOUSE NM_008981 Ptprg uc316vru.1 Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=; Membrane ; Single- pass type I membrane protein Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily. uc316vru.1 
ENSMUST00000249074.1 Cldn34b4 ENSMUST00000249074.1 Cell junction, tight junction (from UniProt Q3V0X2) 4930428D18Rik AK132827 Cldn34b4 Q3V0X2 Q3V0X2_MOUSE uc316vsl.1 Cell junction, tight junction Belongs to the claudin family. molecular_function structural molecule activity cellular_component bicellular tight junction biological_process membrane integral component of membrane uc316vsl.1 
ENSMUST00000249088.1 C130073F10Rik ENSMUST00000249088.1 C130073F10Rik (from geneSymbol) AK081744 C130073F10Rik Q8C4L8 Q8C4L8_MOUSE uc316vss.1 molecular_function cytoplasm biological_process uc316vss.1 
ENSMUST00000249091.1 4930405N21Rik ENSMUST00000249091.1 4930405N21Rik (from geneSymbol) uc316vsv.1 uc316vsv.1 
ENSMUST00000249095.1 ENSMUSG00000121887 ENSMUST00000249095.1 ENSMUSG00000121887 (from geneSymbol) BC080704 uc316vsx.1 uc316vsx.1 
ENSMUST00000249098.1 Pramel39-ps ENSMUST00000249098.1 PRAME like 39, pseudogene (from RefSeq NR_177979.1) NR_177979 uc316vta.1 uc316vta.1 
ENSMUST00000249104.1 Oog2 ENSMUST00000249104.1 Expressed in ovary, specifically in oocytes. Detected in follicles with two layers of granulosa cells, and are present in early as well as large antral follicles. (from UniProt Q7TPX8) AY573562 OOG2_MOUSE Oog2 Q7TPX8 uc316vtb.1 Expressed in ovary, specifically in oocytes. Detected in follicles with two layers of granulosa cells, and are present in early as well as large antral follicles. Belongs to the PRAME family. molecular_function cytoplasm biological_process positive regulation of cell proliferation negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of transcription, DNA-templated uc316vtb.1 
ENSMUST00000249136.2 ENSMUSG00000121514 ENSMUST00000249136.2 ENSMUSG00000121514 (from geneSymbol) A0A6B9UF22 A0A6B9UF22_MOUSE DQ874390 ENSMUST00000249136.1 uc316vtl.1 uc316vtl.2 uc316vtl.1 uc316vtl.2 
ENSMUST00000249137.1 ENSMUSG00000121515 ENSMUST00000249137.1 ENSMUSG00000121515 (from geneSymbol) A0A9L6KE92 A0A9L6KE92_MOUSE uc316vtm.1 uc316vtm.1 
ENSMUST00000249144.1 ENSMUSG00000121519 ENSMUST00000249144.1 ENSMUSG00000121519 (from geneSymbol) A0A9L6KDQ4 A0A9L6KDQ4_MOUSE uc316vtq.1 uc316vtq.1 
ENSMUST00000249145.1 ENSMUSG00000121520 ENSMUST00000249145.1 ENSMUSG00000121520 (from geneSymbol) A0A9L6KDT8 A0A9L6KDT8_MOUSE FJ386433 uc316vtr.1 uc316vtr.1 
ENSMUST00000249146.1 ENSMUSG00000121521 ENSMUST00000249146.1 ENSMUSG00000121521 (from geneSymbol) A0A9L6KDV4 A0A9L6KDV4_MOUSE FJ386433 uc316vts.1 uc316vts.1 
ENSMUST00000249148.1 ENSMUSG00000121523 ENSMUST00000249148.1 ENSMUSG00000121523 (from geneSymbol) A0A9L6KDQ4 A0A9L6KDQ4_MOUSE uc316vtu.1 uc316vtu.1 
ENSMUST00000249149.1 ENSMUSG00000121524 ENSMUST00000249149.1 ENSMUSG00000121524 (from geneSymbol) A0A9L6KE99 A0A9L6KE99_MOUSE FJ386433 uc316vtv.1 uc316vtv.1 
ENSMUST00000249150.1 ENSMUSG00000121525 ENSMUST00000249150.1 ENSMUSG00000121525 (from geneSymbol) A0A9L6KDQ4 A0A9L6KDQ4_MOUSE uc316vtw.1 uc316vtw.1 
ENSMUST00000249151.1 ENSMUSG00000121526 ENSMUST00000249151.1 ENSMUSG00000121526 (from geneSymbol) A0A9L6KDF6 A0A9L6KDF6_MOUSE FJ386433 uc316vtx.1 uc316vtx.1 
ENSMUST00000249152.1 ENSMUSG00000121527 ENSMUST00000249152.1 ENSMUSG00000121527 (from geneSymbol) A0A9L6KDQ4 A0A9L6KDQ4_MOUSE uc316vty.1 uc316vty.1 
ENSMUST00000249153.1 ENSMUSG00000121528 ENSMUST00000249153.1 ENSMUSG00000121528 (from geneSymbol) A0A9L6KDT8 A0A9L6KDT8_MOUSE FJ386433 uc316vtz.1 uc316vtz.1 
ENSMUST00000249154.1 ENSMUSG00000121529 ENSMUST00000249154.1 ENSMUSG00000121529 (from geneSymbol) A0A9L6KEA6 A0A9L6KEA6_MOUSE FJ386433 uc316vua.1 uc316vua.1 
ENSMUST00000249191.1 ENSMUSG00000121543 ENSMUST00000249191.1 ENSMUSG00000121543 (from geneSymbol) A0A9L6KDR4 A0A9L6KDR4_MOUSE uc316vun.1 uc316vun.1 
ENSMUST00000249207.1 ENSMUSG00000121556 ENSMUST00000249207.1 ENSMUSG00000121556 (from geneSymbol) A0A9L6KEB1 A0A9L6KEB1_MOUSE uc316vva.1 uc316vva.1 
ENSMUST00000249208.1 ENSMUSG00000121557 ENSMUST00000249208.1 ENSMUSG00000121557 (from geneSymbol) A0A9L6KDR9 A0A9L6KDR9_MOUSE FJ386435 uc316vvb.1 uc316vvb.1 
ENSMUST00000249239.2 ENSMUSG00000121812 ENSMUST00000249239.2 ENSMUSG00000121812 (from geneSymbol) ENSMUST00000249239.1 uc316vwb.1 uc316vwb.2 uc316vwb.1 uc316vwb.2 
ENSMUST00000249241.1 ENSMUSG00000121570 ENSMUST00000249241.1 ENSMUSG00000121570 (from geneSymbol) A0A9L6KDY4 A0A9L6KDY4_MOUSE AK161554 uc316vwd.1 uc316vwd.1 
ENSMUST00000249242.1 ENSMUSG00000121571 ENSMUST00000249242.1 ENSMUSG00000121571 (from geneSymbol) A0A9L6KDV6 A0A9L6KDV6_MOUSE AK135734 uc316vwe.1 uc316vwe.1 
ENSMUST00000249243.1 ENSMUSG00000121572 ENSMUST00000249243.1 ENSMUSG00000121572 (from geneSymbol) A0A9L6KEC7 A0A9L6KEC7_MOUSE uc316vwf.1 uc316vwf.1 
ENSMUST00000249245.1 ENSMUSG00000121573 ENSMUST00000249245.1 ENSMUSG00000121573 (from geneSymbol) A0A9L6KDH6 A0A9L6KDH6_MOUSE uc316vwh.1 uc316vwh.1 
ENSMUST00000249246.1 ENSMUSG00000121574 ENSMUST00000249246.1 Inhibits lactate dehydrogenase (LDH)-mediated conversion of lactate to pyruvate in mitochondria by competing with mitochondrial LDH for binding to NAD(+). Also inhibits cellular lactate utilization. (from UniProt C0HLV9) C0HLV9 MP31_MOUSE uc316vwi.1 Inhibits lactate dehydrogenase (LDH)-mediated conversion of lactate to pyruvate in mitochondria by competing with mitochondrial LDH for binding to NAD(+). Also inhibits cellular lactate utilization. Interacts with lactate dehydrogenases LDHA and LDHB; interaction with mitochondrial LDH leads to inhibition of lactate dehydrogenase activity, preventing conversion of lactate to pyruvate. Mitochondrion Detected in brain, kidney and liver (at protein level). Enhanced global lactate metabolism with elevated glucose consumption, increased ATP production and decreased perigonadal fat pad weight and fat/body weight ratio (PubMed:33406399). Elevated serum and secreted lactate levels (PubMed:33406399). Conditional knockout in astrocytes results in initiation of gliomagenesis and development of neurological symptoms that include seizure, ataxia and/or paralysis at 55-65 weeks of age (PubMed:33406399). uc316vwi.1 
ENSMUST00000249248.1 ENSMUSG00000121575 ENSMUST00000249248.1 ENSMUSG00000121575 (from geneSymbol) A0A9L6KDW2 A0A9L6KDW2_MOUSE AK148342 uc316vwk.1 uc316vwk.1 
ENSMUST00000249249.1 ENSMUSG00000121576 ENSMUST00000249249.1 ENSMUSG00000121576 (from geneSymbol) A0A9L6KED2 A0A9L6KED2_MOUSE uc316vwl.1 uc316vwl.1 
ENSMUST00000249250.1 ENSMUSG00000121577 ENSMUST00000249250.1 ENSMUSG00000121577 (from geneSymbol) A0A9L6KDT7 A0A9L6KDT7_MOUSE uc316vwm.1 uc316vwm.1 
ENSMUST00000249251.1 ENSMUSG00000121578 ENSMUST00000249251.1 ENSMUSG00000121578 (from geneSymbol) A0A9L6KDH9 A0A9L6KDH9_MOUSE BC141065 uc316vwn.1 uc316vwn.1 
ENSMUST00000249252.1 ENSMUSG00000121579 ENSMUST00000249252.1 ENSMUSG00000121579 (from geneSymbol) A0A9L6KDZ6 A0A9L6KDZ6_MOUSE JN566056 uc316vwo.1 uc316vwo.1 
ENSMUST00000249253.1 ENSMUSG00000121580 ENSMUST00000249253.1 ENSMUSG00000121580 (from geneSymbol) A0A9L6KDW9 A0A9L6KDW9_MOUSE AK191251 uc316vwp.1 uc316vwp.1 
ENSMUST00000249254.1 ENSMUSG00000121581 ENSMUST00000249254.1 ENSMUSG00000121581 (from geneSymbol) A0A9L6KED7 A0A9L6KED7_MOUSE uc316vwq.1 uc316vwq.1 
ENSMUST00000249255.1 ENSMUSG00000121582 ENSMUST00000249255.1 ENSMUSG00000121582 (from geneSymbol) A0A9L6KDU2 A0A9L6KDU2_MOUSE M54798 uc316vwr.1 uc316vwr.1 
ENSMUST00000249256.1 Cox17 ENSMUST00000249256.1 Mitochondrion intermembrane space (from UniProt Q54AC6) AK152968 COX17 Cox17 Q54AC6 Q54AC6_MOUSE uc316vws.1 Mitochondrion intermembrane space Belongs to the COX17 family. copper ion binding mitochondrial intermembrane space copper ion transport copper chaperone activity uc316vws.1 
ENSMUST00000249258.1 Gm38423 ENSMUST00000249258.1 predicted gene, 38423 (from RefSeq NM_001256481.2) F2Z3W5 F2Z3W5_MOUSE Gm11237 Gm38423 Msantd5f5 NM_001256481 uc316vwu.1 This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is inferred from alignment of paralogous transcripts. [provided by RefSeq, Apr 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments and paralogous data. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## molecular_function cellular_component biological_process uc316vwu.1 
ENSMUST00000249261.1 Gm10509 ENSMUST00000249261.1 predicted gene 10509 (from RefSeq NM_001354753.1) A0A9L6KDU7 A0A9L6KDU7_MOUSE Gm10509 NM_001354753 uc316vwx.1 uc316vwx.1 
ENSMUST00000249312.1 Gm17067 ENSMUST00000249312.1 Gm17067 (from geneSymbol) E9Q6S4 E9Q6S4_MOUSE Gm17067 uc316vyw.1 nucleic acid binding regulation of transcription, DNA-templated metal ion binding uc316vyw.1 
ENSMUST00000249317.1 Zscan4e ENSMUST00000249317.1 Chromosome, telomere Nucleus (from UniProt A0A1B0GRE8) A0A1B0GRE8 A0A1B0GRE8_MOUSE Zscan4e uc316vza.1 Chromosome, telomere Nucleus nucleic acid binding transcription factor activity, sequence-specific DNA binding nucleus regulation of transcription, DNA-templated metal ion binding uc316vza.1 
ENSMUST00000249332.3 Gm10378 ENSMUST00000249332.3 Gm10378 (from geneSymbol) ENSMUST00000249332.1 ENSMUST00000249332.2 uc316vzn.1 uc316vzn.2 uc316vzn.3 uc316vzn.1 uc316vzn.2 uc316vzn.3 
ENSMUST00000249337.1 Dcdc2c ENSMUST00000249337.1 doublecortin domain containing 2C, transcript variant 3 (from RefSeq NM_001373958.1) A0AA74KSJ0 NM_001373958 uc316waq.1 uc316waq.1 
ENSMUST00000249356.1 Gm14288 ENSMUST00000249356.1 Gm14288 (from geneSymbol) A0AA74KUN0 BC032262 uc316wbj.1 uc316wbj.1 
ENSMUST00000249365.1 Zfp1009 ENSMUST00000249365.1 Zfp1009 (from geneSymbol) A2CF17 A2CF17_MOUSE AK141151 Zfp968-ps uc316wbs.1 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process uc316wbs.1 
ENSMUST00000249373.1 Gm2832 ENSMUST00000249373.1 Gm2832 (from geneSymbol) A0AA74KT35 uc316wca.1 uc316wca.1 
ENSMUST00000249377.1 Gm2956 ENSMUST00000249377.1 Gm2956 (from geneSymbol) BC040090 E9PVJ0 E9PVJ0_MOUSE Gm2956 Gm3005 uc316wce.1 uc316wce.1 
ENSMUST00000249379.1 Gm3002 ENSMUST00000249379.1 Gm3002 (from geneSymbol) A0AA74KSW7 BC080297 uc316wcg.1 uc316wcg.1 
ENSMUST00000249381.1 Gm3005 ENSMUST00000249381.1 Gm3005 (from geneSymbol) A0AA74KSL3 EF651814 uc316wci.1 uc316wci.1 
ENSMUST00000249385.1 B230307C23Rik ENSMUST00000249385.1 RIKEN cDNA B230307C23 gene, transcript variant 1 (from RefSeq NM_001362093.2) A0AA74KUP2 NM_001362093 uc316wcm.1 uc316wcm.1 
ENSMUST00000249386.1 4930522L14Rik ENSMUST00000249386.1 4930522L14Rik (from geneSymbol) AK019690 uc316wcn.1 uc316wcn.1 
ENSMUST00000249387.1 Gm3095 ENSMUST00000249387.1 Gm3095 (from geneSymbol) A0AA74KSL6 EF651829 uc316wco.1 uc316wco.1 
ENSMUST00000249389.1 AB010352 ENSMUST00000249389.1 cDNA sequence AB010352 (from RefSeq NM_001378279.1) A0AA74KT47 NM_001378279 uc316wcq.1 uc316wcq.1 
ENSMUST00000249394.1 ENSMUSG00000121597 ENSMUST00000249394.1 ENSMUSG00000121597 (from geneSymbol) A0AA74KT52 BC012405 uc316wcv.1 uc316wcv.1 
ENSMUST00000249395.1 Gm3164 ENSMUST00000249395.1 Gm3164 (from geneSymbol) A0AA74KT48 EF651823 uc316wcw.1 uc316wcw.1 
ENSMUST00000249396.1 Gm3248 ENSMUST00000249396.1 Gm3248 (from geneSymbol) EF651824 uc316wcx.1 uc316wcx.1 
ENSMUST00000249397.2 ENSMUSG00000121895 ENSMUST00000249397.2 ENSMUSG00000121895 (from geneSymbol) EF651831 ENSMUST00000249397.1 uc316wcy.1 uc316wcy.2 uc316wcy.1 uc316wcy.2 
ENSMUST00000249401.1 1700020N01Rik ENSMUST00000249401.1 1700020N01Rik (from geneSymbol) 1700020N01Rik AK006179 Q8CF20 Q8CF20_MOUSE uc316wdc.1 molecular_function nucleic acid binding cellular_component regulation of transcription, DNA-templated biological_process uc316wdc.1 
ENSMUST00000249416.1 Gm3327 ENSMUST00000249416.1 predicted gene 3327, transcript variant 3 (from RefSeq NR_168720.1) NR_168720 uc316wdr.1 uc316wdr.1 
ENSMUST00000249417.1 Gm3371 ENSMUST00000249417.1 Gm3371 (from geneSymbol) A0AA74KSM4 uc316wds.1 uc316wds.1 
ENSMUST00000249418.1 Gm3373 ENSMUST00000249418.1 Gm3373 (from geneSymbol) A6NAS7 A6NAS7_MOUSE BC096548 Gm3373 Gm3500 uc316wdt.1 uc316wdt.1 
ENSMUST00000249455.1 Gm3685 ENSMUST00000249455.1 Gm3685 (from geneSymbol) A0AA74KSY8 uc316wfd.1 uc316wfd.1 
ENSMUST00000249471.1 Gm3739 ENSMUST00000249471.1 Gm3739 (from geneSymbol) A0AA74KUR0 BC172015 uc316wft.1 uc316wft.1 
ENSMUST00000249474.1 Gm3752 ENSMUST00000249474.1 predicted gene 3752, transcript variant 5 (from RefSeq NM_001374194.1) A6NAT4 A6NAT4_MOUSE Gm3752 NM_001374194 uc316wfw.1 uc316wfw.1 
ENSMUST00000249476.1 Speer1c ENSMUST00000249476.1 Speer1c (from geneSymbol) Gm5152 L7N200 L7N200_MOUSE Speer3 uc316wfy.1 uc316wfy.1 
ENSMUST00000249493.1 Gm5799 ENSMUST00000249493.1 Gm5799 (from geneSymbol) A0AA74KSN8 uc316wgp.1 uc316wgp.1 
ENSMUST00000249538.1 Gm7995 ENSMUST00000249538.1 predicted gene 7995 (from RefSeq NM_001403667.1) A0AA74KUS0 NM_001403667 uc316wii.1 uc316wii.1 
ENSMUST00000249546.1 Gm8024 ENSMUST00000249546.1 Gm8024 (from geneSymbol) A0AA74KT10 uc316wiq.1 uc316wiq.1 
ENSMUST00000249553.1 Gm20544 ENSMUST00000249553.1 Gm20544 (from geneSymbol) uc316wix.1 uc316wix.1 
ENSMUST00000249569.1 Gm8212 ENSMUST00000249569.1 predicted gene 8212 (from RefSeq NR_166053.1) NR_166053 uc316wjn.1 uc316wjn.1 
ENSMUST00000249586.1 Gm8257 ENSMUST00000249586.1 Gm8257 (from geneSymbol) A0AA74KTE2 uc316wkd.1 uc316wkd.1 
ENSMUST00000249589.1 ENSMUSG00000121900 ENSMUST00000249589.1 ENSMUSG00000121900 (from geneSymbol) BC040090 uc316wkg.1 uc316wkg.1 
ENSMUST00000249593.1 Speer1k ENSMUST00000249593.1 Speer1k (from geneSymbol) A0AA74KT21 uc316wkk.1 uc316wkk.1 
ENSMUST00000249597.1 Gm7233 ENSMUST00000249597.1 Gm7233 (from geneSymbol) AK138450 E9PZI8 E9PZI8_MOUSE E9Q763 Gm7233 Gm8104 uc316wko.1 uc316wko.1 
ENSMUST00000249607.1 Gm3264 ENSMUST00000249607.1 predicted gene, 33933 (from RefSeq NM_001384220.1) A0AA74KT98 NM_001384220 uc316wky.1 uc316wky.1 
ENSMUST00000249618.1 ENSMUSG00000121598 ENSMUST00000249618.1 ENSMUSG00000121598 (from geneSymbol) A0AA74KT45 uc316wlj.1 uc316wlj.1 
ENSMUST00000249631.1 Tincr ENSMUST00000249631.1 TINCR ubiquitin domain containing, transcript variant 1 (from RefSeq NM_001396442.1) A0A1B0GRQ3 A0A1B0GRQ3_MOUSE NM_001396442 Tincr uc316wlw.1 uc316wlw.1 
ENSMUST00000249638.1 Kcnq1ot1 ENSMUST00000249638.1 Kcnq1ot1 (from geneSymbol) uc316wmd.1 uc316wmd.1 
ENSMUST00000249645.1 Malat1 ENSMUST00000249645.1 Malat1 (from geneSymbol) uc316wmk.1 uc316wmk.1 
ENSMUST00000249659.1 ENSMUSG00000121602 ENSMUST00000249659.1 ENSMUSG00000121602 (from geneSymbol) uc331oiq.1 uc331oiq.1 
ENSMUST00000249660.1 ENSMUSG00000121603 ENSMUST00000249660.1 ENSMUSG00000121603 (from geneSymbol) uc331oir.1 uc331oir.1 
ENSMUST00000249662.1 ENSMUSG00000121604 ENSMUST00000249662.1 ENSMUSG00000121604 (from geneSymbol) LF200125 uc331oit.1 uc331oit.1 
ENSMUST00000249663.1 Ahsp ENSMUST00000249663.1 alpha hemoglobin stabilizing protein (from RefSeq NM_133245.2) AHSP_MOUSE Edrf Eraf NM_133245 O70427 Q9CY02 uc331oiu.1 Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. Monomer. Forms a heterodimer with free alpha-hemoglobin. Does not bind beta-hemoglobin nor alpha(2)beta(2) hemoglobin A. Cytoplasm Expressed in spleen, bone marrow, and blood, with highest levels in bone marrow. By GATA-1 during erythroid maturation. Belongs to the AHSP family. cytoplasm protein folding erythrocyte differentiation hemoglobin binding protein stabilization uc331oiu.1 
ENSMUST00000249666.1 Akap17a ENSMUST00000249666.1 A-kinase anchoring protein 17A, transcript variant 1 (from RefSeq NM_001418372.1) NM_001418372 uc331oiw.1 uc331oiw.1 
ENSMUST00000249671.1 Nlgn4l ENSMUST00000249671.1 Nlgn4l (from geneSymbol) EF692521 uc331ojb.1 uc331ojb.1 
ENSMUST00000249672.1 ENSMUSG00000121608 ENSMUST00000249672.1 ENSMUSG00000121608 (from geneSymbol) uc331ojc.1 uc331ojc.1 
ENSMUST00000249673.1 Sts ENSMUST00000249673.1 steroid sulfatase (from RefSeq NM_009293.1) NM_009293 uc331ojd.1 uc331ojd.1 
ENSMUST00000249688.1 Ube2i ENSMUST00000249688.1 Ube2i (from geneSymbol) AK168706 uc331ojs.1 uc331ojs.1 
ENSMUST00000249714.1 ENSMUSG00000121610 ENSMUST00000249714.1 ENSMUSG00000121610 (from geneSymbol) uc331oks.1 uc331oks.1 
ENSMUST00000249756.1 ENSMUSG00000121902 ENSMUST00000249756.1 ENSMUSG00000121902 (from geneSymbol) uc331omc.1 uc331omc.1 
ENSMUST00000249758.1 ENSMUSG00000121903 ENSMUST00000249758.1 ENSMUSG00000121903 (from geneSymbol) uc331ome.1 uc331ome.1 
ENSMUST00000249760.1 ENSMUSG00000121904 ENSMUST00000249760.1 ENSMUSG00000121904 (from geneSymbol) uc331omg.1 uc331omg.1 
ENSMUST00000249761.1 ENSMUSG00000121905 ENSMUST00000249761.1 ENSMUSG00000121905 (from geneSymbol) uc331omh.1 uc331omh.1 
ENSMUST00000249775.1 Sstr5 ENSMUST00000249775.1 Sstr5 (from geneSymbol) AK133609 uc331omv.1 uc331omv.1 
ENSMUST00000249780.2 Gm33801 ENSMUST00000249780.2 Gm33801 (from geneSymbol) ENSMUST00000249780.1 uc331ona.1 uc331ona.2 uc331ona.1 uc331ona.2 
ENSMUST00000249850.1 ENSMUSG00000121908 ENSMUST00000249850.1 ENSMUSG00000121908 (from geneSymbol) uc331peu.1 uc331peu.1 
ENSMUST00000249854.1 ENSMUSG00000121909 ENSMUST00000249854.1 ENSMUSG00000121909 (from geneSymbol) uc331pex.1 uc331pex.1 
ENSMUST00000249855.1 ENSMUSG00000121910 ENSMUST00000249855.1 ENSMUSG00000121910 (from geneSymbol) uc331pey.1 uc331pey.1 
ENSMUST00000249863.1 Tmem67 ENSMUST00000249863.1 Tmem67 (from geneSymbol) AK045429 uc331pff.1 uc331pff.1 
ENSMUST00000249865.1 Fam178b ENSMUST00000249865.1 family with sequence similarity 178, member B, transcript variant E (from RefSeq NM_001372417.1) NM_001372417 uc331pfh.1 uc331pfh.1 
ENSMUST00000249882.1 ENSMUSG00000121912 ENSMUST00000249882.1 ENSMUSG00000121912 (from geneSymbol) uc331pfy.1 uc331pfy.1 
ENSMUST00000249883.1 Gm5134 ENSMUST00000249883.1 Gm5134 (from geneSymbol) AK133270 uc331pfz.1 uc331pfz.1 
ENSMUST00000249896.1 Zc3h4 ENSMUST00000249896.1 zinc finger CCCH-type containing 4, transcript variant 3 (from RefSeq NM_001427311.1) Kiaa1064 NM_001427311 Q6ZPZ3 ZC3H4_MOUSE Zc3h4 uc331pgl.1 RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). Interacts with WDR82. Chromosome Note=Recruited at sites of high RNA polymerase II occupancy. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZPZ3-1; Sequence=Displayed; Name=2; IsoId=Q6ZPZ3-2; Sequence=VSP_018209; Early embryonic lethality: embryos do not survive beyond bastocyst stage due to defective epiblast and primitive endoderm lineages formation. Belongs to the suppressor of sable family. transcription factor activity, sequence-specific DNA binding nucleus nucleoplasm cytosol negative regulation of transcription, DNA-templated metal ion binding uc331pgl.1 
ENSMUST00000249905.1 ENSMUSG00000121913 ENSMUST00000249905.1 ENSMUSG00000121913 (from geneSymbol) AK010990 uc331pgu.1 uc331pgu.1 
ENSMUST00000249906.1 ENSMUSG00000121915 ENSMUST00000249906.1 ENSMUSG00000121915 (from geneSymbol) BC019556 uc331pgv.1 uc331pgv.1 
ENSMUST00000249907.1 Ndfip2 ENSMUST00000249907.1 Membrane ; Multi- pass membrane protein (from UniProt Q3V1V0) AK132235 Ndfip2 Q3V1V0 Q3V1V0_MOUSE uc331pgw.1 Membrane ; Multi- pass membrane protein vacuolar transport membrane integral component of membrane metal ion transport uc331pgw.1 
ENSMUST00000249935.1 ENSMUSG00000121920 ENSMUST00000249935.1 ENSMUSG00000121920 (from geneSymbol) A0A087WQH8 A0A087WQH8_MOUSE AK018546 Slc35a4 uc331phw.1 uc331phw.1 
ENSMUST00000249948.1 ENSMUSG00000121927 ENSMUST00000249948.1 ENSMUSG00000121927 (from geneSymbol) AK082117 uc331rgt.1 uc331rgt.1 
ENSMUST00000249949.1 ENSMUSG00000121926 ENSMUST00000249949.1 limbic system-associated membrane protein, transcript variant 4 (from RefSeq NM_001361282.2) A0A087WP80 A0A087WP80_MOUSE Lsamp NM_001361282 uc331rgu.1 Cell membrane ; Lipid-anchor, GPI-anchor Membrane ; Lipid-anchor, GPI-anchor Belongs to the immunoglobulin superfamily. IgLON family. membrane integral component of membrane uc331rgu.1 
ENSMUST00000249954.1 ENSMUSG00000121933 ENSMUST00000249954.1 predicted gene 1096 (from RefSeq NM_001378224.1) NM_001378224 uc331rgz.1 uc331rgz.1 
ENSMUST00000249955.1 ENSMUSG00000121934 ENSMUST00000249955.1 ENSMUSG00000121934 (from geneSymbol) uc331rha.1 uc331rha.1 
ENSMUST00000249957.1 ENSMUSG00000121936 ENSMUST00000249957.1 ENSMUSG00000121936 (from geneSymbol) uc331rhc.1 uc331rhc.1 
ENSMUST00000249958.1 ENSMUSG00000121937 ENSMUST00000249958.1 ENSMUSG00000121937 (from geneSymbol) uc331rhd.1 uc331rhd.1 
ENSMUST00000249959.1 ENSMUSG00000121938 ENSMUST00000249959.1 ENSMUSG00000121938 (from geneSymbol) uc331rhe.1 uc331rhe.1 
ENSMUST00000249960.1 ENSMUSG00000121939 ENSMUST00000249960.1 ENSMUSG00000121939 (from geneSymbol) uc331rhf.1 uc331rhf.1 
ENSMUST00000249961.1 ENSMUSG00000121940 ENSMUST00000249961.1 ENSMUSG00000121940 (from geneSymbol) uc331rhg.1 uc331rhg.1 
ENSMUST00000249962.1 ENSMUSG00000121941 ENSMUST00000249962.1 ENSMUSG00000121941 (from geneSymbol) uc331rhh.1 uc331rhh.1 
ENSMUST00000249964.1 ENSMUSG00000121943 ENSMUST00000249964.1 ENSMUSG00000121943 (from geneSymbol) uc331rhj.1 uc331rhj.1 
ENSMUST00000249966.1 ENSMUSG00000121945 ENSMUST00000249966.1 ENSMUSG00000121945 (from geneSymbol) uc331rhl.1 uc331rhl.1 
ENSMUST00000249968.1 ENSMUSG00000121947 ENSMUST00000249968.1 ENSMUSG00000121947 (from geneSymbol) uc331rhn.1 uc331rhn.1 
ENSMUST00000249970.1 ENSMUSG00000121949 ENSMUST00000249970.1 ENSMUSG00000121949 (from geneSymbol) uc331rhp.1 uc331rhp.1 
ENSMUST00000249971.1 ENSMUSG00000121950 ENSMUST00000249971.1 ENSMUSG00000121950 (from geneSymbol) uc331rhq.1 uc331rhq.1 
ENSMUST00000249972.1 ENSMUSG00000121951 ENSMUST00000249972.1 ENSMUSG00000121951 (from geneSymbol) uc331rhr.1 uc331rhr.1 
ENSMUST00000249973.1 ENSMUSG00000121952 ENSMUST00000249973.1 ENSMUSG00000121952 (from geneSymbol) uc331rhs.1 uc331rhs.1 
ENSMUST00000249975.1 ENSMUSG00000121954 ENSMUST00000249975.1 ENSMUSG00000121954 (from geneSymbol) uc331rhu.1 uc331rhu.1 
ENSMUST00000249976.1 ENSMUSG00000121955 ENSMUST00000249976.1 ENSMUSG00000121955 (from geneSymbol) uc331rhv.1 uc331rhv.1 
ENSMUST00000249979.1 ENSMUSG00000121958 ENSMUST00000249979.1 ENSMUSG00000121958 (from geneSymbol) uc331rhy.1 uc331rhy.1 
ENSMUST00000249989.1 ENSMUSG00000121968 ENSMUST00000249989.1 ENSMUSG00000121968 (from geneSymbol) uc331rii.1 uc331rii.1 
ENSMUST00000249990.1 Gm35586 ENSMUST00000249990.1 predicted gene, 35586 (from RefSeq NM_001378704.1) NM_001378704 uc331rij.1 uc331rij.1 
ENSMUST00000249994.1 ENSMUSG00000121973 ENSMUST00000249994.1 ENSMUSG00000121973 (from geneSymbol) uc331rin.1 uc331rin.1 
ENSMUST00000249995.1 ENSMUSG00000121974 ENSMUST00000249995.1 ENSMUSG00000121974 (from geneSymbol) uc331rio.1 uc331rio.1 
ENSMUST00000249996.1 ENSMUSG00000121975 ENSMUST00000249996.1 ENSMUSG00000121975 (from geneSymbol) uc331rip.1 uc331rip.1 
ENSMUST00000249997.1 ENSMUSG00000121976 ENSMUST00000249997.1 ENSMUSG00000121976 (from geneSymbol) AK139719 uc331riq.1 uc331riq.1 
ENSMUST00000249998.1 Setd2 ENSMUST00000249998.1 Setd2 (from geneSymbol) BC059049 uc331rir.1 uc331rir.1 
ENSMUST00000249999.1 Gcna ENSMUST00000249999.1 Gcna (from geneSymbol) KX981576 uc331ris.1 uc331ris.1 
ENSMUST00000250002.1 Neu3 ENSMUST00000250002.1 neuraminidase 3, transcript variant 2 (from RefSeq NM_001418463.1) NM_001418463 Neu3 Q543I9 Q543I9_MOUSE uc331riv.1 Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha- (2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.; EC=3.2.1.18; Evidence=; Belongs to the glycosyl hydrolase 33 family. exo-alpha-sialidase activity plasma membrane carbohydrate metabolic process ganglioside catabolic process oligosaccharide catabolic process alpha-sialidase activity uc331riv.1 
ENSMUST00000250014.1 Gm572 ENSMUST00000250014.1 predicted gene 572, transcript variant 1 (from RefSeq NM_001368835.1) NM_001368835 uc331rjh.1 uc331rjh.1 
ENSMUST00000250017.1 S100a13 ENSMUST00000250017.1 S100 calcium binding protein A13, transcript variant 1 (from RefSeq NM_009113.6) NM_009113 Q545H7 Q545H7_MOUSE S100a13 uc331rjk.1 copper ion binding calcium ion binding uc331rjk.1 
ENSMUST00000250023.1 Bmncr ENSMUST00000250023.1 Bmncr (from geneSymbol) uc331rjq.1 uc331rjq.1 
ENSMUST00000250024.1 Sox2ot ENSMUST00000250024.1 Sox2ot (from geneSymbol) AK045614 uc331rjr.1 uc331rjr.1 
ENSMUST00000250028.1 Platr11 ENSMUST00000250028.1 Platr11 (from geneSymbol) uc331rjv.1 uc331rjv.1 
ENSMUST00000250045.1 Vis1 ENSMUST00000250045.1 Vis1 (from geneSymbol) AK039697 uc331rkm.1 uc331rkm.1 
ENSMUST00000250059.1 Trp53cor1 ENSMUST00000250059.1 Trp53cor1 (from geneSymbol) HM210889 uc331rla.1 uc331rla.1 
ENSMUST00000250060.1 2700054A10Rik ENSMUST00000250060.1 2700054A10Rik (from geneSymbol) BC068229 uc331rlb.1 uc331rlb.1 
ENSMUST00000250081.1 Platr29 ENSMUST00000250081.1 Platr29 (from geneSymbol) KY467915 uc331rlw.1 uc331rlw.1 
ENSMUST00000250093.1 Lncbate6 ENSMUST00000250093.1 Lncbate6 (from geneSymbol) AK155516 uc331rmi.1 uc331rmi.1 
ENSMUST00000250094.1 Gm47754 ENSMUST00000250094.1 Gm47754 (from geneSymbol) uc331rmj.1 uc331rmj.1 
ENSMUST00000250115.1 Gm28511 ENSMUST00000250115.1 Gm28511 (from geneSymbol) uc331rne.1 uc331rne.1 
ENSMUST00000250120.1 Gm14023 ENSMUST00000250120.1 Gm14023 (from geneSymbol) AK035070 uc331rnj.1 uc331rnj.1 
ENSMUST00000250122.1 Il1bos ENSMUST00000250122.1 Il1bos (from geneSymbol) AK076405 uc331rnl.1 uc331rnl.1 
ENSMUST00000250133.1 ENSMUSG00000121983 ENSMUST00000250133.1 ENSMUSG00000121983 (from geneSymbol) uc331rnw.1 uc331rnw.1 
ENSMUST00000250145.1 2810471M01Rik ENSMUST00000250145.1 2810471M01Rik (from geneSymbol) AK013397 uc331roi.1 uc331roi.1 
ENSMUST00000250155.1 Pantr2 ENSMUST00000250155.1 Pantr2 (from geneSymbol) BC059892 uc331ros.1 uc331ros.1 
ENSMUST00000250158.1 Ube4bos2 ENSMUST00000250158.1 Ube4bos2 (from geneSymbol) AK007223 uc331rov.1 uc331rov.1 
ENSMUST00000250159.1 Gjd2os ENSMUST00000250159.1 Gjd2os (from geneSymbol) AK082110 uc331row.1 uc331row.1 
ENSMUST00000250161.1 Actc1dt ENSMUST00000250161.1 Actc1dt (from geneSymbol) AK081828 uc331roy.1 uc331roy.1 
ENSMUST00000250162.1 ENSMUSG00000121985 ENSMUST00000250162.1 ENSMUSG00000121985 (from geneSymbol) AK007057 uc331roz.1 uc331roz.1 
ENSMUST00000250166.1 Gad1os ENSMUST00000250166.1 Gad1os (from geneSymbol) AK005124 uc331rpd.1 uc331rpd.1 
ENSMUST00000250169.1 Tmem147os ENSMUST00000250169.1 Tmem147os (from geneSymbol) AK049951 uc331rpg.1 uc331rpg.1 
ENSMUST00000250174.1 Gm20757 ENSMUST00000250174.1 Gm20757 (from geneSymbol) AK053604 uc331rpl.1 uc331rpl.1 
ENSMUST00000250179.1 ENSMUSG00000121987 ENSMUST00000250179.1 ENSMUSG00000121987 (from geneSymbol) AK086758 uc331rpq.1 uc331rpq.1 
ENSMUST00000250182.1 Tmem147os ENSMUST00000250182.1 Tmem147os (from geneSymbol) AK049951 uc331rpt.1 uc331rpt.1 
ENSMUST00000250187.1 ENSMUSG00000121988 ENSMUST00000250187.1 ENSMUSG00000121988 (from geneSymbol) uc331rpy.1 uc331rpy.1 
ENSMUST00000250189.1 Gm34030 ENSMUST00000250189.1 Gm34030 (from geneSymbol) uc331rqa.1 uc331rqa.1 
ENSMUST00000250195.1 ENSMUSG00000121990 ENSMUST00000250195.1 ENSMUSG00000121990 (from geneSymbol) uc331rqg.1 uc331rqg.1 
ENSMUST00000250200.1 ENSMUSG00000121995 ENSMUST00000250200.1 ENSMUSG00000121995 (from geneSymbol) uc331rql.1 uc331rql.1 
ENSMUST00000250201.1 ENSMUSG00000121997 ENSMUST00000250201.1 ENSMUSG00000121997 (from geneSymbol) uc331rqm.1 uc331rqm.1 
ENSMUST00000250202.1 ENSMUSG00000121998 ENSMUST00000250202.1 ENSMUSG00000121998 (from geneSymbol) uc331rqn.1 uc331rqn.1 
ENSMUST00000250203.1 ENSMUSG00000121996 ENSMUST00000250203.1 ENSMUSG00000121996 (from geneSymbol) uc331rqo.1 uc331rqo.1 
ENSMUST00000250204.1 ENSMUSG00000121999 ENSMUST00000250204.1 ENSMUSG00000121999 (from geneSymbol) uc331rqp.1 uc331rqp.1 
ENSMUST00000250205.1 ENSMUSG00000121994 ENSMUST00000250205.1 ENSMUSG00000121994 (from geneSymbol) uc331rqq.1 uc331rqq.1 
ENSMUST00000250211.1 ENSMUSG00000122000 ENSMUST00000250211.1 ENSMUSG00000122000 (from geneSymbol) uc331rqw.1 uc331rqw.1 
ENSMUST00000250212.1 ENSMUSG00000122002 ENSMUST00000250212.1 ENSMUSG00000122002 (from geneSymbol) uc331rqx.1 uc331rqx.1 
ENSMUST00000250213.1 ENSMUSG00000122001 ENSMUST00000250213.1 ENSMUSG00000122001 (from geneSymbol) uc331rqy.1 uc331rqy.1 
ENSMUST00000250217.1 ENSMUSG00000122003 ENSMUST00000250217.1 ENSMUSG00000122003 (from geneSymbol) AK079515 uc331rrc.1 uc331rrc.1 
ENSMUST00000250218.1 ENSMUSG00000122004 ENSMUST00000250218.1 ENSMUSG00000122004 (from geneSymbol) uc331rrd.1 uc331rrd.1 
ENSMUST00000250220.1 ENSMUSG00000122005 ENSMUST00000250220.1 ENSMUSG00000122005 (from geneSymbol) uc331rrf.1 uc331rrf.1 
ENSMUST00000250226.1 ENSMUSG00000122006 ENSMUST00000250226.1 ENSMUSG00000122006 (from geneSymbol) uc331rrl.1 uc331rrl.1 
ENSMUST00000250227.1 ENSMUSG00000122007 ENSMUST00000250227.1 ENSMUSG00000122007 (from geneSymbol) uc331rrm.1 uc331rrm.1 
ENSMUST00000250228.1 ENSMUSG00000122008 ENSMUST00000250228.1 ENSMUSG00000122008 (from geneSymbol) uc331rrn.1 uc331rrn.1 
ENSMUST00000250229.1 ENSMUSG00000122009 ENSMUST00000250229.1 ENSMUSG00000122009 (from geneSymbol) uc331rro.1 uc331rro.1 
ENSMUST00000250232.1 ENSMUSG00000122010 ENSMUST00000250232.1 ENSMUSG00000122010 (from geneSymbol) uc331rrr.1 uc331rrr.1 
ENSMUST00000250244.1 ENSMUSG00000122011 ENSMUST00000250244.1 ENSMUSG00000122011 (from geneSymbol) LF196117 uc331rsd.1 uc331rsd.1 
ENSMUST00000250245.1 4930590L20Rik ENSMUST00000250245.1 4930590L20Rik (from geneSymbol) AK016382 uc331rse.1 uc331rse.1 
ENSMUST00000250247.1 ENSMUSG00000122012 ENSMUST00000250247.1 ENSMUSG00000122012 (from geneSymbol) uc331rsg.1 uc331rsg.1 
ENSMUST00000250249.1 ENSMUSG00000122013 ENSMUST00000250249.1 ENSMUSG00000122013 (from geneSymbol) uc331rsi.1 uc331rsi.1 
ENSMUST00000250250.1 ENSMUSG00000122014 ENSMUST00000250250.1 ENSMUSG00000122014 (from geneSymbol) uc331rsj.1 uc331rsj.1 
ENSMUST00000250264.1 ENSMUSG00000122015 ENSMUST00000250264.1 ENSMUSG00000122015 (from geneSymbol) uc331rsx.1 uc331rsx.1 
ENSMUST00000250265.1 ENSMUSG00000122016 ENSMUST00000250265.1 ENSMUSG00000122016 (from geneSymbol) uc331rsy.1 uc331rsy.1 
ENSMUST00000250266.1 ENSMUSG00000122017 ENSMUST00000250266.1 ENSMUSG00000122017 (from geneSymbol) uc331rsz.1 uc331rsz.1 
ENSMUST00000250274.1 Gm42375 ENSMUST00000250274.1 Gm42375 (from geneSymbol) uc331rth.1 uc331rth.1 
ENSMUST00000250286.1 ENSMUSG00000122018 ENSMUST00000250286.1 ENSMUSG00000122018 (from geneSymbol) uc331rtt.1 uc331rtt.1 
ENSMUST00000250287.1 ENSMUSG00000122019 ENSMUST00000250287.1 ENSMUSG00000122019 (from geneSymbol) uc331rtu.1 uc331rtu.1 
ENSMUST00000250291.1 ENSMUSG00000122020 ENSMUST00000250291.1 ENSMUSG00000122020 (from geneSymbol) uc331rty.1 uc331rty.1 
ENSMUST00000250294.1 ENSMUSG00000122022 ENSMUST00000250294.1 ENSMUSG00000122022 (from geneSymbol) uc331rtz.1 uc331rtz.1 
ENSMUST00000250304.1 ENSMUSG00000122024 ENSMUST00000250304.1 ENSMUSG00000122024 (from geneSymbol) uc331ruj.1 uc331ruj.1 
ENSMUST00000250309.1 ENSMUSG00000122023 ENSMUST00000250309.1 ENSMUSG00000122023 (from geneSymbol) uc331ruo.1 uc331ruo.1 
ENSMUST00000250310.1 ENSMUSG00000122025 ENSMUST00000250310.1 ENSMUSG00000122025 (from geneSymbol) uc331rup.1 uc331rup.1 
ENSMUST00000250319.1 4933406B15Rik ENSMUST00000250319.1 4933406B15Rik (from geneSymbol) AK016679 uc331ruy.1 uc331ruy.1 
ENSMUST00000250323.1 ENSMUSG00000122026 ENSMUST00000250323.1 ENSMUSG00000122026 (from geneSymbol) uc331rvc.1 uc331rvc.1 
ENSMUST00000250324.1 ENSMUSG00000122027 ENSMUST00000250324.1 ENSMUSG00000122027 (from geneSymbol) uc331rvd.1 uc331rvd.1 
ENSMUST00000250325.1 ENSMUSG00000122028 ENSMUST00000250325.1 ENSMUSG00000122028 (from geneSymbol) LF198107 uc331rve.1 uc331rve.1 
ENSMUST00000250330.1 Gm30842 ENSMUST00000250330.1 Gm30842 (from geneSymbol) uc331rvj.1 uc331rvj.1 
ENSMUST00000250365.1 Gm56574 ENSMUST00000250365.1 Gm56574 (from geneSymbol) uc331rwr.1 uc331rwr.1 
ENSMUST00000250390.1 ENSMUSG00000122029 ENSMUST00000250390.1 ENSMUSG00000122029 (from geneSymbol) uc331rxq.1 uc331rxq.1 
ENSMUST00000250391.1 ENSMUSG00000122030 ENSMUST00000250391.1 ENSMUSG00000122030 (from geneSymbol) uc331rxr.1 uc331rxr.1 
ENSMUST00000250392.1 ENSMUSG00000122031 ENSMUST00000250392.1 ENSMUSG00000122031 (from geneSymbol) uc331rxs.1 uc331rxs.1 
ENSMUST00000250393.1 ENSMUSG00000122032 ENSMUST00000250393.1 ENSMUSG00000122032 (from geneSymbol) uc331rxt.1 uc331rxt.1 
ENSMUST00000250394.1 ENSMUSG00000122033 ENSMUST00000250394.1 ENSMUSG00000122033 (from geneSymbol) uc331rxu.1 uc331rxu.1 
ENSMUST00000250398.1 4922502N22Rik ENSMUST00000250398.1 4922502N22Rik (from geneSymbol) AK015023 uc331rxy.1 uc331rxy.1 
ENSMUST00000250401.1 ENSMUSG00000122034 ENSMUST00000250401.1 ENSMUSG00000122034 (from geneSymbol) uc331ryb.1 uc331ryb.1 
ENSMUST00000250402.1 ENSMUSG00000122035 ENSMUST00000250402.1 ENSMUSG00000122035 (from geneSymbol) uc331ryc.1 uc331ryc.1 
ENSMUST00000250409.1 ENSMUSG00000122036 ENSMUST00000250409.1 ENSMUSG00000122036 (from geneSymbol) uc331ryj.1 uc331ryj.1 
ENSMUST00000250410.1 ENSMUSG00000122037 ENSMUST00000250410.1 ENSMUSG00000122037 (from geneSymbol) uc331ryk.1 uc331ryk.1 
ENSMUST00000250411.1 ENSMUSG00000122038 ENSMUST00000250411.1 ENSMUSG00000122038 (from geneSymbol) uc331ryl.1 uc331ryl.1 
ENSMUST00000250425.1 ENSMUSG00000122039 ENSMUST00000250425.1 ENSMUSG00000122039 (from geneSymbol) uc331ryz.1 uc331ryz.1 
ENSMUST00000250426.1 ENSMUSG00000122040 ENSMUST00000250426.1 ENSMUSG00000122040 (from geneSymbol) uc331rza.1 uc331rza.1 
ENSMUST00000250428.1 ENSMUSG00000122041 ENSMUST00000250428.1 ENSMUSG00000122041 (from geneSymbol) uc331rzc.1 uc331rzc.1 
ENSMUST00000250433.1 ENSMUSG00000122042 ENSMUST00000250433.1 ENSMUSG00000122042 (from geneSymbol) uc331rzh.1 uc331rzh.1 
ENSMUST00000250434.1 ENSMUSG00000122043 ENSMUST00000250434.1 ENSMUSG00000122043 (from geneSymbol) uc331rzi.1 uc331rzi.1 
ENSMUST00000250436.1 ENSMUSG00000122044 ENSMUST00000250436.1 ENSMUSG00000122044 (from geneSymbol) uc331rzk.1 uc331rzk.1 
ENSMUST00000250438.1 ENSMUSG00000122045 ENSMUST00000250438.1 ENSMUSG00000122045 (from geneSymbol) uc331rzm.1 uc331rzm.1 
ENSMUST00000250445.1 ENSMUSG00000122046 ENSMUST00000250445.1 ENSMUSG00000122046 (from geneSymbol) uc331rzt.1 uc331rzt.1 
ENSMUST00000250446.1 ENSMUSG00000122047 ENSMUST00000250446.1 ENSMUSG00000122047 (from geneSymbol) uc331rzu.1 uc331rzu.1 
ENSMUST00000250475.1 ENSMUSG00000122048 ENSMUST00000250475.1 ENSMUSG00000122048 (from geneSymbol) uc331sax.1 uc331sax.1 
ENSMUST00000250491.1 ENSMUSG00000122049 ENSMUST00000250491.1 ENSMUSG00000122049 (from geneSymbol) uc331sbn.1 uc331sbn.1 
ENSMUST00000250492.1 ENSMUSG00000122050 ENSMUST00000250492.1 ENSMUSG00000122050 (from geneSymbol) uc331sbo.1 uc331sbo.1 
ENSMUST00000250494.1 ENSMUSG00000122051 ENSMUST00000250494.1 ENSMUSG00000122051 (from geneSymbol) uc331sbq.1 uc331sbq.1 
ENSMUST00000250498.1 ENSMUSG00000122052 ENSMUST00000250498.1 ENSMUSG00000122052 (from geneSymbol) uc331sbt.1 uc331sbt.1 
ENSMUST00000250499.1 ENSMUSG00000122053 ENSMUST00000250499.1 ENSMUSG00000122053 (from geneSymbol) uc331sbu.1 uc331sbu.1 
ENSMUST00000250500.1 ENSMUSG00000122054 ENSMUST00000250500.1 ENSMUSG00000122054 (from geneSymbol) uc331sbv.1 uc331sbv.1 
ENSMUST00000250501.1 ENSMUSG00000122055 ENSMUST00000250501.1 ENSMUSG00000122055 (from geneSymbol) uc331sbw.1 uc331sbw.1 
ENSMUST00000250508.1 ENSMUSG00000122056 ENSMUST00000250508.1 ENSMUSG00000122056 (from geneSymbol) uc331scd.1 uc331scd.1 
ENSMUST00000250509.1 ENSMUSG00000122057 ENSMUST00000250509.1 ENSMUSG00000122057 (from geneSymbol) uc331sce.1 uc331sce.1 
ENSMUST00000250515.1 ENSMUSG00000122058 ENSMUST00000250515.1 ENSMUSG00000122058 (from geneSymbol) uc331sck.1 uc331sck.1 
ENSMUST00000250516.1 ENSMUSG00000122059 ENSMUST00000250516.1 ENSMUSG00000122059 (from geneSymbol) uc331scl.1 uc331scl.1 
ENSMUST00000250518.1 ENSMUSG00000122060 ENSMUST00000250518.1 predicted gene 20472 (from RefSeq NR_169039.1) NR_169039 uc331scn.1 uc331scn.1 
ENSMUST00000250521.1 ENSMUSG00000122061 ENSMUST00000250521.1 ENSMUSG00000122061 (from geneSymbol) uc331scq.1 uc331scq.1 
ENSMUST00000250528.1 ENSMUSG00000122062 ENSMUST00000250528.1 ENSMUSG00000122062 (from geneSymbol) uc331scx.1 uc331scx.1 
ENSMUST00000250531.1 ENSMUSG00000122063 ENSMUST00000250531.1 ENSMUSG00000122063 (from geneSymbol) uc331sda.1 uc331sda.1 
ENSMUST00000250532.1 ENSMUSG00000122064 ENSMUST00000250532.1 ENSMUSG00000122064 (from geneSymbol) uc331sdb.1 uc331sdb.1 
ENSMUST00000250534.1 ENSMUSG00000122065 ENSMUST00000250534.1 ENSMUSG00000122065 (from geneSymbol) uc331sdd.1 uc331sdd.1 
ENSMUST00000250535.1 ENSMUSG00000122066 ENSMUST00000250535.1 ENSMUSG00000122066 (from geneSymbol) uc331sde.1 uc331sde.1 
ENSMUST00000250537.1 ENSMUSG00000122067 ENSMUST00000250537.1 ENSMUSG00000122067 (from geneSymbol) uc331sdg.1 uc331sdg.1 
ENSMUST00000250539.1 Gm56948 ENSMUST00000250539.1 Gm56948 (from geneSymbol) uc331sdi.1 uc331sdi.1 
ENSMUST00000250543.1 ENSMUSG00000122068 ENSMUST00000250543.1 ENSMUSG00000122068 (from geneSymbol) uc331sdm.1 uc331sdm.1 
ENSMUST00000250556.1 Gm57014 ENSMUST00000250556.1 Gm57014 (from geneSymbol) uc331sdz.1 uc331sdz.1 
ENSMUST00000250581.1 ENSMUSG00000122069 ENSMUST00000250581.1 ENSMUSG00000122069 (from geneSymbol) uc331sey.1 uc331sey.1 
ENSMUST00000250585.1 Gm36287 ENSMUST00000250585.1 Gm36287 (from geneSymbol) uc331sfc.1 uc331sfc.1 
ENSMUST00000250663.1 ENSMUSG00000122070 ENSMUST00000250663.1 ENSMUSG00000122070 (from geneSymbol) uc331sic.1 uc331sic.1 
ENSMUST00000250664.1 ENSMUSG00000122071 ENSMUST00000250664.1 ENSMUSG00000122071 (from geneSymbol) uc331sid.1 uc331sid.1 
ENSMUST00000250665.1 ENSMUSG00000122072 ENSMUST00000250665.1 predicted gene, 34531 (from RefSeq NM_001384241.1) NM_001384241 uc331sie.1 uc331sie.1 
ENSMUST00000250667.1 ENSMUSG00000122073 ENSMUST00000250667.1 ENSMUSG00000122073 (from geneSymbol) uc331sig.1 uc331sig.1 
ENSMUST00000250669.1 Gm44689 ENSMUST00000250669.1 Gm44689 (from geneSymbol) uc331sih.1 uc331sih.1 
ENSMUST00000250673.1 ENSMUSG00000122074 ENSMUST00000250673.1 ENSMUSG00000122074 (from geneSymbol) uc331sil.1 uc331sil.1 
ENSMUST00000250676.1 ENSMUSG00000122075 ENSMUST00000250676.1 ENSMUSG00000122075 (from geneSymbol) uc331sio.1 uc331sio.1 
ENSMUST00000250681.1 ENSMUSG00000122076 ENSMUST00000250681.1 ENSMUSG00000122076 (from geneSymbol) uc331sit.1 uc331sit.1 
ENSMUST00000250683.1 ENSMUSG00000122077 ENSMUST00000250683.1 ENSMUSG00000122077 (from geneSymbol) uc331siu.1 uc331siu.1 
ENSMUST00000250686.1 ENSMUSG00000122079 ENSMUST00000250686.1 ENSMUSG00000122079 (from geneSymbol) uc331siw.1 uc331siw.1 
ENSMUST00000250687.1 ENSMUSG00000122080 ENSMUST00000250687.1 ENSMUSG00000122080 (from geneSymbol) uc331six.1 uc331six.1 
ENSMUST00000250688.1 Gm26777 ENSMUST00000250688.1 Gm26777 (from geneSymbol) AK045378 uc331siy.1 uc331siy.1 
ENSMUST00000250700.1 ENSMUSG00000122081 ENSMUST00000250700.1 ENSMUSG00000122081 (from geneSymbol) uc331sjk.1 uc331sjk.1 
ENSMUST00000250701.1 ENSMUSG00000122082 ENSMUST00000250701.1 ENSMUSG00000122082 (from geneSymbol) uc331sjl.1 uc331sjl.1 
ENSMUST00000250702.1 ENSMUSG00000122084 ENSMUST00000250702.1 ENSMUSG00000122084 (from geneSymbol) uc331sjm.1 uc331sjm.1 
ENSMUST00000250703.1 ENSMUSG00000122083 ENSMUST00000250703.1 ENSMUSG00000122083 (from geneSymbol) uc331sjn.1 uc331sjn.1 
ENSMUST00000250705.1 ENSMUSG00000122085 ENSMUST00000250705.1 ENSMUSG00000122085 (from geneSymbol) uc331sjp.1 uc331sjp.1 
ENSMUST00000250707.1 Gm30244 ENSMUST00000250707.1 Gm30244 (from geneSymbol) uc331sjr.1 uc331sjr.1 
ENSMUST00000250711.1 ENSMUSG00000122087 ENSMUST00000250711.1 ENSMUSG00000122087 (from geneSymbol) uc331sjv.1 uc331sjv.1 
ENSMUST00000250713.1 ENSMUSG00000122088 ENSMUST00000250713.1 ENSMUSG00000122088 (from geneSymbol) uc331sjx.1 uc331sjx.1 
ENSMUST00000250714.1 ENSMUSG00000122089 ENSMUST00000250714.1 ENSMUSG00000122089 (from geneSymbol) uc331sjy.1 uc331sjy.1 
ENSMUST00000250716.1 ENSMUSG00000122090 ENSMUST00000250716.1 ENSMUSG00000122090 (from geneSymbol) uc331ska.1 uc331ska.1 
ENSMUST00000250720.1 ENSMUSG00000122091 ENSMUST00000250720.1 ENSMUSG00000122091 (from geneSymbol) uc331ske.1 uc331ske.1 
ENSMUST00000250721.1 ENSMUSG00000122092 ENSMUST00000250721.1 ENSMUSG00000122092 (from geneSymbol) uc331skf.1 uc331skf.1 
ENSMUST00000250723.1 ENSMUSG00000122093 ENSMUST00000250723.1 ENSMUSG00000122093 (from geneSymbol) uc331skh.1 uc331skh.1 
ENSMUST00000250727.1 ENSMUSG00000122094 ENSMUST00000250727.1 ENSMUSG00000122094 (from geneSymbol) AK137583 uc331skl.1 uc331skl.1 
ENSMUST00000250729.1 ENSMUSG00000122095 ENSMUST00000250729.1 ENSMUSG00000122095 (from geneSymbol) uc331skn.1 uc331skn.1 
ENSMUST00000250730.1 ENSMUSG00000122096 ENSMUST00000250730.1 ENSMUSG00000122096 (from geneSymbol) uc331sko.1 uc331sko.1 
ENSMUST00000250731.1 ENSMUSG00000122097 ENSMUST00000250731.1 ENSMUSG00000122097 (from geneSymbol) uc331skp.1 uc331skp.1 
ENSMUST00000250733.1 ENSMUSG00000122098 ENSMUST00000250733.1 ENSMUSG00000122098 (from geneSymbol) uc331skr.1 uc331skr.1 
ENSMUST00000250738.1 Gm31786 ENSMUST00000250738.1 Gm31786 (from geneSymbol) AK029624 uc331skw.1 uc331skw.1 
ENSMUST00000250783.1 ENSMUSG00000122099 ENSMUST00000250783.1 ENSMUSG00000122099 (from geneSymbol) uc331smp.1 uc331smp.1 
ENSMUST00000250784.1 ENSMUSG00000122100 ENSMUST00000250784.1 ENSMUSG00000122100 (from geneSymbol) uc331smq.1 uc331smq.1 
ENSMUST00000250785.1 ENSMUSG00000122101 ENSMUST00000250785.1 ENSMUSG00000122101 (from geneSymbol) uc331smr.1 uc331smr.1 
ENSMUST00000250789.1 Tspan2os ENSMUST00000250789.1 Tspan2os (from geneSymbol) uc331smv.1 uc331smv.1 
ENSMUST00000250812.1 Gm48105 ENSMUST00000250812.1 Gm48105 (from geneSymbol) AK019801 uc331sns.1 uc331sns.1 
ENSMUST00000250818.1 ENSMUSG00000122102 ENSMUST00000250818.1 ENSMUSG00000122102 (from geneSymbol) uc331sny.1 uc331sny.1 
ENSMUST00000250820.1 ENSMUSG00000122103 ENSMUST00000250820.1 ENSMUSG00000122103 (from geneSymbol) uc331soa.1 uc331soa.1 
ENSMUST00000250825.1 Gm42794 ENSMUST00000250825.1 Gm42794 (from geneSymbol) uc331sof.1 uc331sof.1 
ENSMUST00000250831.1 ENSMUSG00000122104 ENSMUST00000250831.1 ENSMUSG00000122104 (from geneSymbol) uc331sol.1 uc331sol.1 
ENSMUST00000250837.1 ENSMUSG00000122105 ENSMUST00000250837.1 ENSMUSG00000122105 (from geneSymbol) uc331sor.1 uc331sor.1 
ENSMUST00000250841.1 ENSMUSG00000122106 ENSMUST00000250841.1 ENSMUSG00000122106 (from geneSymbol) uc331sov.1 uc331sov.1 
ENSMUST00000250844.1 ENSMUSG00000122107 ENSMUST00000250844.1 ENSMUSG00000122107 (from geneSymbol) uc331soy.1 uc331soy.1 
ENSMUST00000250845.1 ENSMUSG00000122108 ENSMUST00000250845.1 ENSMUSG00000122108 (from geneSymbol) uc331soz.1 uc331soz.1 
ENSMUST00000250853.1 ENSMUSG00000122109 ENSMUST00000250853.1 ENSMUSG00000122109 (from geneSymbol) uc331sph.1 uc331sph.1 
ENSMUST00000250857.1 ENSMUSG00000122110 ENSMUST00000250857.1 ENSMUSG00000122110 (from geneSymbol) uc331spl.1 uc331spl.1 
ENSMUST00000250858.1 ENSMUSG00000122111 ENSMUST00000250858.1 ENSMUSG00000122111 (from geneSymbol) uc331spm.1 uc331spm.1 
ENSMUST00000250861.1 ENSMUSG00000121481 ENSMUST00000250861.1 ENSMUSG00000121481 (from geneSymbol) uc331spp.1 uc331spp.1 
ENSMUST00000250880.1 ENSMUSG00000122112 ENSMUST00000250880.1 ENSMUSG00000122112 (from geneSymbol) uc331sqi.1 uc331sqi.1 
ENSMUST00000250881.1 ENSMUSG00000122113 ENSMUST00000250881.1 ENSMUSG00000122113 (from geneSymbol) uc331sqj.1 uc331sqj.1 
ENSMUST00000250885.1 ENSMUSG00000122114 ENSMUST00000250885.1 ENSMUSG00000122114 (from geneSymbol) uc331sqn.1 uc331sqn.1 
ENSMUST00000250929.1 ENSMUSG00000122115 ENSMUST00000250929.1 ENSMUSG00000122115 (from geneSymbol) uc331sse.1 uc331sse.1 
ENSMUST00000250931.1 ENSMUSG00000122116 ENSMUST00000250931.1 ENSMUSG00000122116 (from geneSymbol) uc331ssg.1 uc331ssg.1 
ENSMUST00000250934.1 ENSMUSG00000122117 ENSMUST00000250934.1 ENSMUSG00000122117 (from geneSymbol) LF196988 uc331ssj.1 uc331ssj.1 
ENSMUST00000250936.1 Gm56913 ENSMUST00000250936.1 Gm56913 (from geneSymbol) uc331ssl.1 uc331ssl.1 
ENSMUST00000250937.1 ENSMUSG00000122118 ENSMUST00000250937.1 ENSMUSG00000122118 (from geneSymbol) uc331ssm.1 uc331ssm.1 
ENSMUST00000250939.1 ENSMUSG00000122119 ENSMUST00000250939.1 ENSMUSG00000122119 (from geneSymbol) uc331sso.1 uc331sso.1 
ENSMUST00000250940.1 ENSMUSG00000122120 ENSMUST00000250940.1 ENSMUSG00000122120 (from geneSymbol) uc331ssp.1 uc331ssp.1 
ENSMUST00000250941.1 ENSMUSG00000122121 ENSMUST00000250941.1 ENSMUSG00000122121 (from geneSymbol) uc331ssq.1 uc331ssq.1 
ENSMUST00000250944.1 ENSMUSG00000122122 ENSMUST00000250944.1 ENSMUSG00000122122 (from geneSymbol) uc331sst.1 uc331sst.1 
ENSMUST00000250945.1 ENSMUSG00000122123 ENSMUST00000250945.1 ENSMUSG00000122123 (from geneSymbol) uc331ssu.1 uc331ssu.1 
ENSMUST00000250946.1 ENSMUSG00000122124 ENSMUST00000250946.1 ENSMUSG00000122124 (from geneSymbol) uc331ssv.1 uc331ssv.1 
ENSMUST00000250947.1 Gm13016 ENSMUST00000250947.1 predicted gene 13016, transcript variant 2 (from RefSeq NR_151509.1) NR_151509 uc331ssw.1 uc331ssw.1 
ENSMUST00000250950.1 ENSMUSG00000122125 ENSMUST00000250950.1 ENSMUSG00000122125 (from geneSymbol) uc331ssz.1 uc331ssz.1 
ENSMUST00000250951.1 ENSMUSG00000122126 ENSMUST00000250951.1 ENSMUSG00000122126 (from geneSymbol) uc331sta.1 uc331sta.1 
ENSMUST00000250955.1 Gm28380 ENSMUST00000250955.1 Gm28380 (from geneSymbol) uc331ste.1 uc331ste.1 
ENSMUST00000250966.1 ENSMUSG00000122127 ENSMUST00000250966.1 ENSMUSG00000122127 (from geneSymbol) uc331stp.1 uc331stp.1 
ENSMUST00000250970.1 ENSMUSG00000122128 ENSMUST00000250970.1 ENSMUSG00000122128 (from geneSymbol) uc331stt.1 uc331stt.1 
ENSMUST00000250971.1 ENSMUSG00000122129 ENSMUST00000250971.1 ENSMUSG00000122129 (from geneSymbol) uc331stu.1 uc331stu.1 
ENSMUST00000250972.1 ENSMUSG00000122130 ENSMUST00000250972.1 ENSMUSG00000122130 (from geneSymbol) uc331stv.1 uc331stv.1 
ENSMUST00000250973.1 ENSMUSG00000122131 ENSMUST00000250973.1 ENSMUSG00000122131 (from geneSymbol) uc331stw.1 uc331stw.1 
ENSMUST00000250986.1 ENSMUSG00000122132 ENSMUST00000250986.1 ENSMUSG00000122132 (from geneSymbol) uc331suj.1 uc331suj.1 
ENSMUST00000250987.1 ENSMUSG00000122133 ENSMUST00000250987.1 ENSMUSG00000122133 (from geneSymbol) uc331suk.1 uc331suk.1 
ENSMUST00000250991.1 ENSMUSG00000122134 ENSMUST00000250991.1 ENSMUSG00000122134 (from geneSymbol) uc331suo.1 uc331suo.1 
ENSMUST00000250992.1 Gm37587 ENSMUST00000250992.1 Gm37587 (from geneSymbol) uc331sup.1 uc331sup.1 
ENSMUST00000250997.1 ENSMUSG00000122135 ENSMUST00000250997.1 ENSMUSG00000122135 (from geneSymbol) uc331suu.1 uc331suu.1 
ENSMUST00000251005.1 ENSMUSG00000122136 ENSMUST00000251005.1 ENSMUSG00000122136 (from geneSymbol) uc331svc.1 uc331svc.1 
ENSMUST00000251006.1 ENSMUSG00000122137 ENSMUST00000251006.1 ENSMUSG00000122137 (from geneSymbol) uc331svd.1 uc331svd.1 
ENSMUST00000251009.1 ENSMUSG00000122138 ENSMUST00000251009.1 ENSMUSG00000122138 (from geneSymbol) uc331svg.1 uc331svg.1 
ENSMUST00000251021.1 ENSMUSG00000122139 ENSMUST00000251021.1 ENSMUSG00000122139 (from geneSymbol) uc331svs.1 uc331svs.1 
ENSMUST00000251025.1 ENSMUSG00000122140 ENSMUST00000251025.1 ENSMUSG00000122140 (from geneSymbol) uc331svw.1 uc331svw.1 
ENSMUST00000251031.1 Gm40513 ENSMUST00000251031.1 Gm40513 (from geneSymbol) uc331swc.1 uc331swc.1 
ENSMUST00000251039.1 ENSMUSG00000122141 ENSMUST00000251039.1 ENSMUSG00000122141 (from geneSymbol) uc331swk.1 uc331swk.1 
ENSMUST00000251045.1 ENSMUSG00000122142 ENSMUST00000251045.1 ENSMUSG00000122142 (from geneSymbol) uc331swq.1 uc331swq.1 
ENSMUST00000251046.1 ENSMUSG00000122143 ENSMUST00000251046.1 ENSMUSG00000122143 (from geneSymbol) uc331swr.1 uc331swr.1 
ENSMUST00000251048.1 ENSMUSG00000122144 ENSMUST00000251048.1 ENSMUSG00000122144 (from geneSymbol) uc331swt.1 uc331swt.1 
ENSMUST00000251049.1 ENSMUSG00000122145 ENSMUST00000251049.1 ENSMUSG00000122145 (from geneSymbol) uc331swu.1 uc331swu.1 
ENSMUST00000251050.1 ENSMUSG00000122146 ENSMUST00000251050.1 ENSMUSG00000122146 (from geneSymbol) uc331swv.1 uc331swv.1 
ENSMUST00000251051.1 ENSMUSG00000122147 ENSMUST00000251051.1 ENSMUSG00000122147 (from geneSymbol) uc331sww.1 uc331sww.1 
ENSMUST00000251052.1 ENSMUSG00000122148 ENSMUST00000251052.1 ENSMUSG00000122148 (from geneSymbol) uc331swx.1 uc331swx.1 
ENSMUST00000251053.1 ENSMUSG00000122149 ENSMUST00000251053.1 ENSMUSG00000122149 (from geneSymbol) uc331swy.1 uc331swy.1 
ENSMUST00000251068.1 Gm56620 ENSMUST00000251068.1 Gm56620 (from geneSymbol) uc331sxm.1 uc331sxm.1 
ENSMUST00000251079.1 ENSMUSG00000122150 ENSMUST00000251079.1 ENSMUSG00000122150 (from geneSymbol) uc331sxx.1 uc331sxx.1 
ENSMUST00000251080.1 ENSMUSG00000122151 ENSMUST00000251080.1 ENSMUSG00000122151 (from geneSymbol) uc331sxy.1 uc331sxy.1 
ENSMUST00000251081.1 ENSMUSG00000122152 ENSMUST00000251081.1 ENSMUSG00000122152 (from geneSymbol) uc331sxz.1 uc331sxz.1 
ENSMUST00000251082.1 4930588J15Rik ENSMUST00000251082.1 4930588J15Rik (from geneSymbol) AK016367 uc331sya.1 uc331sya.1 
ENSMUST00000251096.1 Gm4489 ENSMUST00000251096.1 Gm4489 (from geneSymbol) uc331syo.1 uc331syo.1 
ENSMUST00000251105.1 ENSMUSG00000122153 ENSMUST00000251105.1 ENSMUSG00000122153 (from geneSymbol) uc331syx.1 uc331syx.1 
ENSMUST00000251107.1 ENSMUSG00000122154 ENSMUST00000251107.1 ENSMUSG00000122154 (from geneSymbol) uc331syz.1 uc331syz.1 
ENSMUST00000251109.1 ENSMUSG00000122155 ENSMUST00000251109.1 ENSMUSG00000122155 (from geneSymbol) uc331sza.1 uc331sza.1 
ENSMUST00000251113.1 ENSMUSG00000122157 ENSMUST00000251113.1 ENSMUSG00000122157 (from geneSymbol) uc331szd.1 uc331szd.1 
ENSMUST00000251119.1 ENSMUSG00000122158 ENSMUST00000251119.1 ENSMUSG00000122158 (from geneSymbol) uc331szj.1 uc331szj.1 
ENSMUST00000251123.1 ENSMUSG00000122159 ENSMUST00000251123.1 ENSMUSG00000122159 (from geneSymbol) uc331szn.1 uc331szn.1 
ENSMUST00000251124.1 ENSMUSG00000122160 ENSMUST00000251124.1 ENSMUSG00000122160 (from geneSymbol) uc331szo.1 uc331szo.1 
ENSMUST00000251125.1 ENSMUSG00000122161 ENSMUST00000251125.1 ENSMUSG00000122161 (from geneSymbol) uc331szp.1 uc331szp.1 
ENSMUST00000251127.1 ENSMUSG00000122162 ENSMUST00000251127.1 ENSMUSG00000122162 (from geneSymbol) uc331szr.1 uc331szr.1 
ENSMUST00000251128.1 ENSMUSG00000122163 ENSMUST00000251128.1 ENSMUSG00000122163 (from geneSymbol) uc331szs.1 uc331szs.1 
ENSMUST00000251130.1 ENSMUSG00000122164 ENSMUST00000251130.1 ENSMUSG00000122164 (from geneSymbol) uc331szu.1 uc331szu.1 
ENSMUST00000251147.1 Gm56525 ENSMUST00000251147.1 Gm56525 (from geneSymbol) uc331tal.1 uc331tal.1 
ENSMUST00000251156.1 Gm12279 ENSMUST00000251156.1 Gm12279 (from geneSymbol) KY467594 uc331tau.1 uc331tau.1 
ENSMUST00000251180.1 ENSMUSG00000122165 ENSMUST00000251180.1 ENSMUSG00000122165 (from geneSymbol) uc331tbs.1 uc331tbs.1 
ENSMUST00000251181.1 4930517G24Rik ENSMUST00000251181.1 4930517G24Rik (from geneSymbol) AK015813 uc331tbt.1 uc331tbt.1 
ENSMUST00000251206.1 ENSMUSG00000122167 ENSMUST00000251206.1 ENSMUSG00000122167 (from geneSymbol) uc331tco.1 uc331tco.1 
ENSMUST00000251207.1 ENSMUSG00000122168 ENSMUST00000251207.1 ENSMUSG00000122168 (from geneSymbol) uc331tcp.1 uc331tcp.1 
ENSMUST00000251208.1 ENSMUSG00000122169 ENSMUST00000251208.1 ENSMUSG00000122169 (from geneSymbol) uc331tcq.1 uc331tcq.1 
ENSMUST00000251209.1 ENSMUSG00000122170 ENSMUST00000251209.1 ENSMUSG00000122170 (from geneSymbol) uc331tcr.1 uc331tcr.1 
ENSMUST00000251210.1 ENSMUSG00000122171 ENSMUST00000251210.1 ENSMUSG00000122171 (from geneSymbol) uc331tcs.1 uc331tcs.1 
ENSMUST00000251211.1 ENSMUSG00000122172 ENSMUST00000251211.1 ENSMUSG00000122172 (from geneSymbol) uc331tct.1 uc331tct.1 
ENSMUST00000251214.1 ENSMUSG00000122173 ENSMUST00000251214.1 ENSMUSG00000122173 (from geneSymbol) uc331tcw.1 uc331tcw.1 
ENSMUST00000251216.1 ENSMUSG00000122174 ENSMUST00000251216.1 ENSMUSG00000122174 (from geneSymbol) uc331tcy.1 uc331tcy.1 
ENSMUST00000251217.1 ENSMUSG00000122175 ENSMUST00000251217.1 ENSMUSG00000122175 (from geneSymbol) uc331tcz.1 uc331tcz.1 
ENSMUST00000251219.1 ENSMUSG00000122176 ENSMUST00000251219.1 ENSMUSG00000122176 (from geneSymbol) uc331tdb.1 uc331tdb.1 
ENSMUST00000251220.1 ENSMUSG00000122177 ENSMUST00000251220.1 ENSMUSG00000122177 (from geneSymbol) uc331tdc.1 uc331tdc.1 
ENSMUST00000251221.1 ENSMUSG00000122178 ENSMUST00000251221.1 ENSMUSG00000122178 (from geneSymbol) uc331tdd.1 uc331tdd.1 
ENSMUST00000251223.1 ENSMUSG00000122179 ENSMUST00000251223.1 ENSMUSG00000122179 (from geneSymbol) uc331tdf.1 uc331tdf.1 
ENSMUST00000251230.1 ENSMUSG00000122180 ENSMUST00000251230.1 ENSMUSG00000122180 (from geneSymbol) uc331tdm.1 uc331tdm.1 
ENSMUST00000251231.1 Gm36411 ENSMUST00000251231.1 Gm36411 (from geneSymbol) KY467583 uc331tdn.1 uc331tdn.1 
ENSMUST00000251233.1 ENSMUSG00000122181 ENSMUST00000251233.1 ENSMUSG00000122181 (from geneSymbol) uc331tdp.1 uc331tdp.1 
ENSMUST00000251234.1 ENSMUSG00000122182 ENSMUST00000251234.1 ENSMUSG00000122182 (from geneSymbol) uc331tdq.1 uc331tdq.1 
ENSMUST00000251235.1 ENSMUSG00000122183 ENSMUST00000251235.1 ENSMUSG00000122183 (from geneSymbol) uc331tdr.1 uc331tdr.1 
ENSMUST00000251241.1 ENSMUSG00000122184 ENSMUST00000251241.1 ENSMUSG00000122184 (from geneSymbol) uc331tdx.1 uc331tdx.1 
ENSMUST00000251242.1 ENSMUSG00000122185 ENSMUST00000251242.1 ENSMUSG00000122185 (from geneSymbol) uc331tdy.1 uc331tdy.1 
ENSMUST00000251243.1 ENSMUSG00000122186 ENSMUST00000251243.1 ENSMUSG00000122186 (from geneSymbol) uc331tdz.1 uc331tdz.1 
ENSMUST00000251246.1 ENSMUSG00000122187 ENSMUST00000251246.1 ENSMUSG00000122187 (from geneSymbol) uc331tec.1 uc331tec.1 
ENSMUST00000251247.1 ENSMUSG00000122188 ENSMUST00000251247.1 ENSMUSG00000122188 (from geneSymbol) uc331ted.1 uc331ted.1 
ENSMUST00000251263.1 ENSMUSG00000122189 ENSMUST00000251263.1 ENSMUSG00000122189 (from geneSymbol) uc331tet.1 uc331tet.1 
ENSMUST00000251264.1 ENSMUSG00000122190 ENSMUST00000251264.1 ENSMUSG00000122190 (from geneSymbol) uc331teu.1 uc331teu.1 
ENSMUST00000251268.1 ENSMUSG00000122191 ENSMUST00000251268.1 ENSMUSG00000122191 (from geneSymbol) uc331tey.1 uc331tey.1 
ENSMUST00000251269.1 ENSMUSG00000122192 ENSMUST00000251269.1 ENSMUSG00000122192 (from geneSymbol) uc331tez.1 uc331tez.1 
ENSMUST00000251272.1 ENSMUSG00000122193 ENSMUST00000251272.1 ENSMUSG00000122193 (from geneSymbol) uc331tfc.1 uc331tfc.1 
ENSMUST00000251275.1 ENSMUSG00000122194 ENSMUST00000251275.1 ENSMUSG00000122194 (from geneSymbol) L04852 uc331tff.1 uc331tff.1 
ENSMUST00000251279.1 Gm36496 ENSMUST00000251279.1 Gm36496 (from geneSymbol) uc331tfj.1 uc331tfj.1 
ENSMUST00000251287.1 ENSMUSG00000122195 ENSMUST00000251287.1 ENSMUSG00000122195 (from geneSymbol) uc331tfr.1 uc331tfr.1 
ENSMUST00000251290.1 ENSMUSG00000122196 ENSMUST00000251290.1 ENSMUSG00000122196 (from geneSymbol) uc331tfu.1 uc331tfu.1 
ENSMUST00000251293.1 ENSMUSG00000122198 ENSMUST00000251293.1 ENSMUSG00000122198 (from geneSymbol) uc331tfv.1 uc331tfv.1 
ENSMUST00000251294.1 ENSMUSG00000122199 ENSMUST00000251294.1 ENSMUSG00000122199 (from geneSymbol) uc331tfw.1 uc331tfw.1 
ENSMUST00000251301.1 ENSMUSG00000122200 ENSMUST00000251301.1 ENSMUSG00000122200 (from geneSymbol) uc331tgd.1 uc331tgd.1 
ENSMUST00000251302.1 ENSMUSG00000122201 ENSMUST00000251302.1 ENSMUSG00000122201 (from geneSymbol) uc331tge.1 uc331tge.1 
ENSMUST00000251307.1 ENSMUSG00000122202 ENSMUST00000251307.1 ENSMUSG00000122202 (from geneSymbol) uc331tgj.1 uc331tgj.1 
ENSMUST00000251341.1 D730005E14Rik ENSMUST00000251341.1 D730005E14Rik (from geneSymbol) uc331thr.1 uc331thr.1 
ENSMUST00000251347.1 ENSMUSG00000122204 ENSMUST00000251347.1 ENSMUSG00000122204 (from geneSymbol) uc331thx.1 uc331thx.1 
ENSMUST00000251348.1 ENSMUSG00000122205 ENSMUST00000251348.1 ENSMUSG00000122205 (from geneSymbol) uc331thy.1 uc331thy.1 
ENSMUST00000251352.1 ENSMUSG00000122206 ENSMUST00000251352.1 ENSMUSG00000122206 (from geneSymbol) uc331tic.1 uc331tic.1 
ENSMUST00000251359.1 ENSMUSG00000122207 ENSMUST00000251359.1 ENSMUSG00000122207 (from geneSymbol) uc331tij.1 uc331tij.1 
ENSMUST00000251360.1 ENSMUSG00000122208 ENSMUST00000251360.1 ENSMUSG00000122208 (from geneSymbol) uc331tik.1 uc331tik.1 
ENSMUST00000251361.1 ENSMUSG00000122209 ENSMUST00000251361.1 ENSMUSG00000122209 (from geneSymbol) uc331til.1 uc331til.1 
ENSMUST00000251364.1 Gm43617 ENSMUST00000251364.1 Gm43617 (from geneSymbol) uc331tio.1 uc331tio.1 
ENSMUST00000251365.1 ENSMUSG00000122210 ENSMUST00000251365.1 ENSMUSG00000122210 (from geneSymbol) uc331tip.1 uc331tip.1 
ENSMUST00000251366.1 ENSMUSG00000122211 ENSMUST00000251366.1 ENSMUSG00000122211 (from geneSymbol) uc331tiq.1 uc331tiq.1 
ENSMUST00000251368.1 ENSMUSG00000122212 ENSMUST00000251368.1 ENSMUSG00000122212 (from geneSymbol) uc331tis.1 uc331tis.1 
ENSMUST00000251373.1 ENSMUSG00000122213 ENSMUST00000251373.1 ENSMUSG00000122213 (from geneSymbol) uc331tix.1 uc331tix.1 
ENSMUST00000251378.1 ENSMUSG00000122214 ENSMUST00000251378.1 ENSMUSG00000122214 (from geneSymbol) uc331tjc.1 uc331tjc.1 
ENSMUST00000251390.1 ENSMUSG00000122215 ENSMUST00000251390.1 ENSMUSG00000122215 (from geneSymbol) uc331tjo.1 uc331tjo.1 
ENSMUST00000251392.1 ENSMUSG00000122216 ENSMUST00000251392.1 ENSMUSG00000122216 (from geneSymbol) uc331tjq.1 uc331tjq.1 
ENSMUST00000251393.1 ENSMUSG00000122217 ENSMUST00000251393.1 ENSMUSG00000122217 (from geneSymbol) uc331tjr.1 uc331tjr.1 
ENSMUST00000251395.1 ENSMUSG00000122218 ENSMUST00000251395.1 ENSMUSG00000122218 (from geneSymbol) uc331tjt.1 uc331tjt.1 
ENSMUST00000251396.1 ENSMUSG00000122219 ENSMUST00000251396.1 ENSMUSG00000122219 (from geneSymbol) uc331tju.1 uc331tju.1 
ENSMUST00000251411.1 ENSMUSG00000122220 ENSMUST00000251411.1 ENSMUSG00000122220 (from geneSymbol) uc331tkj.1 uc331tkj.1 
ENSMUST00000251416.1 ENSMUSG00000122221 ENSMUST00000251416.1 ENSMUSG00000122221 (from geneSymbol) uc331tkn.1 uc331tkn.1 
ENSMUST00000251419.1 ENSMUSG00000122222 ENSMUST00000251419.1 ENSMUSG00000122222 (from geneSymbol) uc331tkq.1 uc331tkq.1 
ENSMUST00000251424.1 1700029J03Rik ENSMUST00000251424.1 1700029J03Rik (from geneSymbol) AK006500 uc331tkv.1 uc331tkv.1 
ENSMUST00000251442.1 ENSMUSG00000122223 ENSMUST00000251442.1 ENSMUSG00000122223 (from geneSymbol) uc331tln.1 uc331tln.1 
ENSMUST00000251443.1 ENSMUSG00000122224 ENSMUST00000251443.1 ENSMUSG00000122224 (from geneSymbol) uc331tlo.1 uc331tlo.1 
ENSMUST00000251444.1 ENSMUSG00000122225 ENSMUST00000251444.1 ENSMUSG00000122225 (from geneSymbol) uc331tlp.1 uc331tlp.1 
ENSMUST00000251446.1 ENSMUSG00000122226 ENSMUST00000251446.1 ENSMUSG00000122226 (from geneSymbol) uc331tlr.1 uc331tlr.1 
ENSMUST00000251447.1 Gm11780 ENSMUST00000251447.1 Gm11780 (from geneSymbol) uc331tls.1 uc331tls.1 
ENSMUST00000251450.1 ENSMUSG00000122228 ENSMUST00000251450.1 ENSMUSG00000122228 (from geneSymbol) uc331tlv.1 uc331tlv.1 
ENSMUST00000251452.1 ENSMUSG00000122229 ENSMUST00000251452.1 ENSMUSG00000122229 (from geneSymbol) uc331tlx.1 uc331tlx.1 
ENSMUST00000251454.1 ENSMUSG00000122230 ENSMUST00000251454.1 ENSMUSG00000122230 (from geneSymbol) uc331tlz.1 uc331tlz.1 
ENSMUST00000251456.1 ENSMUSG00000122231 ENSMUST00000251456.1 ENSMUSG00000122231 (from geneSymbol) uc331tmb.1 uc331tmb.1 
ENSMUST00000251458.1 ENSMUSG00000122232 ENSMUST00000251458.1 ENSMUSG00000122232 (from geneSymbol) uc331tmd.1 uc331tmd.1 
ENSMUST00000251459.1 ENSMUSG00000122233 ENSMUST00000251459.1 ENSMUSG00000122233 (from geneSymbol) uc331tme.1 uc331tme.1 
ENSMUST00000251460.1 ENSMUSG00000122234 ENSMUST00000251460.1 ENSMUSG00000122234 (from geneSymbol) uc331tmf.1 uc331tmf.1 
ENSMUST00000251462.1 Gm50302 ENSMUST00000251462.1 Gm50302 (from geneSymbol) uc331tmh.1 uc331tmh.1 
ENSMUST00000251464.1 ENSMUSG00000122235 ENSMUST00000251464.1 ENSMUSG00000122235 (from geneSymbol) uc331tmj.1 uc331tmj.1 
ENSMUST00000251465.1 ENSMUSG00000122236 ENSMUST00000251465.1 ENSMUSG00000122236 (from geneSymbol) uc331tmk.1 uc331tmk.1 
ENSMUST00000251467.1 ENSMUSG00000122238 ENSMUST00000251467.1 ENSMUSG00000122238 (from geneSymbol) uc331tml.1 uc331tml.1 
ENSMUST00000251469.1 ENSMUSG00000122239 ENSMUST00000251469.1 ENSMUSG00000122239 (from geneSymbol) uc331tmn.1 uc331tmn.1 
ENSMUST00000251470.1 ENSMUSG00000122240 ENSMUST00000251470.1 ENSMUSG00000122240 (from geneSymbol) uc331tmo.1 uc331tmo.1 
ENSMUST00000251471.1 ENSMUSG00000122241 ENSMUST00000251471.1 ENSMUSG00000122241 (from geneSymbol) uc331tmp.1 uc331tmp.1 
ENSMUST00000251473.1 ENSMUSG00000122242 ENSMUST00000251473.1 ENSMUSG00000122242 (from geneSymbol) uc331tmr.1 uc331tmr.1 
ENSMUST00000251477.1 ENSMUSG00000122243 ENSMUST00000251477.1 ENSMUSG00000122243 (from geneSymbol) uc331tmv.1 uc331tmv.1 
ENSMUST00000251481.1 ENSMUSG00000122244 ENSMUST00000251481.1 ENSMUSG00000122244 (from geneSymbol) uc331tmz.1 uc331tmz.1 
ENSMUST00000251489.1 4933417O13Rik ENSMUST00000251489.1 4933417O13Rik (from geneSymbol) AK016851 uc331tng.1 uc331tng.1 
ENSMUST00000251517.1 ENSMUSG00000122245 ENSMUST00000251517.1 ENSMUSG00000122245 (from geneSymbol) uc331tod.1 uc331tod.1 
ENSMUST00000251519.1 ENSMUSG00000122247 ENSMUST00000251519.1 ENSMUSG00000122247 (from geneSymbol) uc331toe.1 uc331toe.1 
ENSMUST00000251520.1 ENSMUSG00000122248 ENSMUST00000251520.1 ENSMUSG00000122248 (from geneSymbol) uc331tof.1 uc331tof.1 
ENSMUST00000251581.1 ENSMUSG00000122249 ENSMUST00000251581.1 ENSMUSG00000122249 (from geneSymbol) uc331tqo.1 uc331tqo.1 
ENSMUST00000251588.1 ENSMUSG00000122250 ENSMUST00000251588.1 ENSMUSG00000122250 (from geneSymbol) uc331tqv.1 uc331tqv.1 
ENSMUST00000251590.1 ENSMUSG00000122251 ENSMUST00000251590.1 ENSMUSG00000122251 (from geneSymbol) uc331tqx.1 uc331tqx.1 
ENSMUST00000251591.1 ENSMUSG00000122252 ENSMUST00000251591.1 ENSMUSG00000122252 (from geneSymbol) uc331tqy.1 uc331tqy.1 
ENSMUST00000251594.1 ENSMUSG00000122253 ENSMUST00000251594.1 ENSMUSG00000122253 (from geneSymbol) uc331trb.1 uc331trb.1 
ENSMUST00000251595.1 ENSMUSG00000122254 ENSMUST00000251595.1 ENSMUSG00000122254 (from geneSymbol) uc331trc.1 uc331trc.1 
ENSMUST00000251596.1 ENSMUSG00000122255 ENSMUST00000251596.1 ENSMUSG00000122255 (from geneSymbol) uc331trd.1 uc331trd.1 
ENSMUST00000251597.1 ENSMUSG00000122256 ENSMUST00000251597.1 ENSMUSG00000122256 (from geneSymbol) uc331tre.1 uc331tre.1 
ENSMUST00000251598.1 ENSMUSG00000122257 ENSMUST00000251598.1 ENSMUSG00000122257 (from geneSymbol) uc331trf.1 uc331trf.1 
ENSMUST00000251600.1 ENSMUSG00000122258 ENSMUST00000251600.1 ENSMUSG00000122258 (from geneSymbol) uc331trh.1 uc331trh.1 
ENSMUST00000251601.1 ENSMUSG00000122259 ENSMUST00000251601.1 ENSMUSG00000122259 (from geneSymbol) uc331tri.1 uc331tri.1 
ENSMUST00000251608.1 Gm44812 ENSMUST00000251608.1 Gm44812 (from geneSymbol) uc331tro.1 uc331tro.1 
ENSMUST00000251615.1 ENSMUSG00000122260 ENSMUST00000251615.1 ENSMUSG00000122260 (from geneSymbol) uc331trv.1 uc331trv.1 
ENSMUST00000251616.1 ENSMUSG00000122261 ENSMUST00000251616.1 ENSMUSG00000122261 (from geneSymbol) uc331trw.1 uc331trw.1 
ENSMUST00000251618.1 ENSMUSG00000122262 ENSMUST00000251618.1 ENSMUSG00000122262 (from geneSymbol) uc331try.1 uc331try.1 
ENSMUST00000251629.1 ENSMUSG00000122263 ENSMUST00000251629.1 ENSMUSG00000122263 (from geneSymbol) uc331tsj.1 uc331tsj.1 
ENSMUST00000251687.1 Gm47390 ENSMUST00000251687.1 Gm47390 (from geneSymbol) uc331tup.1 uc331tup.1 
ENSMUST00000251688.1 ENSMUSG00000122264 ENSMUST00000251688.1 ENSMUSG00000122264 (from geneSymbol) uc331tuq.1 uc331tuq.1 
ENSMUST00000251694.1 ENSMUSG00000122265 ENSMUST00000251694.1 ENSMUSG00000122265 (from geneSymbol) uc331tuw.1 uc331tuw.1 
ENSMUST00000251696.1 ENSMUSG00000122266 ENSMUST00000251696.1 ENSMUSG00000122266 (from geneSymbol) uc331tuy.1 uc331tuy.1 
ENSMUST00000251697.1 ENSMUSG00000122267 ENSMUST00000251697.1 ENSMUSG00000122267 (from geneSymbol) uc331tuz.1 uc331tuz.1 
ENSMUST00000251698.1 ENSMUSG00000122268 ENSMUST00000251698.1 ENSMUSG00000122268 (from geneSymbol) uc331tva.1 uc331tva.1 
ENSMUST00000251699.1 ENSMUSG00000122269 ENSMUST00000251699.1 ENSMUSG00000122269 (from geneSymbol) uc331tvb.1 uc331tvb.1 
ENSMUST00000251700.1 Gsdmcl1 ENSMUST00000251700.1 Gsdmcl1 (from geneSymbol) AK006248 uc331tvc.1 uc331tvc.1 
ENSMUST00000251721.1 ENSMUSG00000122270 ENSMUST00000251721.1 ENSMUSG00000122270 (from geneSymbol) uc331tvx.1 uc331tvx.1 
ENSMUST00000251732.1 ENSMUSG00000122271 ENSMUST00000251732.1 ENSMUSG00000122271 (from geneSymbol) uc331twi.1 uc331twi.1 
ENSMUST00000251734.1 Gm49631 ENSMUST00000251734.1 Gm49631 (from geneSymbol) uc331twk.1 uc331twk.1 
ENSMUST00000251737.1 ENSMUSG00000122272 ENSMUST00000251737.1 ENSMUSG00000122272 (from geneSymbol) uc331twn.1 uc331twn.1 
ENSMUST00000251742.1 ENSMUSG00000122273 ENSMUST00000251742.1 ENSMUSG00000122273 (from geneSymbol) uc331tws.1 uc331tws.1 
ENSMUST00000251744.1 Cdk6os1 ENSMUST00000251744.1 Cdk6os1 (from geneSymbol) uc331twu.1 uc331twu.1 
ENSMUST00000251783.1 2310026L22Rik ENSMUST00000251783.1 2310026L22Rik (from geneSymbol) AK009512 uc331tyh.1 uc331tyh.1 
ENSMUST00000251786.1 ENSMUSG00000122275 ENSMUST00000251786.1 ENSMUSG00000122275 (from geneSymbol) uc331tyk.1 uc331tyk.1 
ENSMUST00000251789.1 ENSMUSG00000122276 ENSMUST00000251789.1 ENSMUSG00000122276 (from geneSymbol) uc331tyn.1 uc331tyn.1 
ENSMUST00000251800.1 ENSMUSG00000122277 ENSMUST00000251800.1 ENSMUSG00000122277 (from geneSymbol) uc331tyy.1 uc331tyy.1 
ENSMUST00000251801.1 ENSMUSG00000122278 ENSMUST00000251801.1 ENSMUSG00000122278 (from geneSymbol) uc331tyz.1 uc331tyz.1 
ENSMUST00000251802.1 ENSMUSG00000122279 ENSMUST00000251802.1 ENSMUSG00000122279 (from geneSymbol) uc331tza.1 uc331tza.1 
ENSMUST00000251805.1 ENSMUSG00000122280 ENSMUST00000251805.1 ENSMUSG00000122280 (from geneSymbol) uc331tzd.1 uc331tzd.1 
ENSMUST00000251808.1 ENSMUSG00000122281 ENSMUST00000251808.1 ENSMUSG00000122281 (from geneSymbol) LF199114 uc331tzg.1 uc331tzg.1 
ENSMUST00000251809.1 ENSMUSG00000122282 ENSMUST00000251809.1 ENSMUSG00000122282 (from geneSymbol) uc331tzh.1 uc331tzh.1 
ENSMUST00000251810.1 ENSMUSG00000122283 ENSMUST00000251810.1 ENSMUSG00000122283 (from geneSymbol) uc331tzi.1 uc331tzi.1 
ENSMUST00000251811.1 ENSMUSG00000122284 ENSMUST00000251811.1 ENSMUSG00000122284 (from geneSymbol) uc331tzj.1 uc331tzj.1 
ENSMUST00000251812.1 ENSMUSG00000122285 ENSMUST00000251812.1 ENSMUSG00000122285 (from geneSymbol) uc331tzk.1 uc331tzk.1 
ENSMUST00000251813.1 ENSMUSG00000122286 ENSMUST00000251813.1 ENSMUSG00000122286 (from geneSymbol) uc331tzl.1 uc331tzl.1 
ENSMUST00000251817.1 ENSMUSG00000122287 ENSMUST00000251817.1 ENSMUSG00000122287 (from geneSymbol) uc331tzp.1 uc331tzp.1 
ENSMUST00000251821.1 ENSMUSG00000122288 ENSMUST00000251821.1 ENSMUSG00000122288 (from geneSymbol) uc331tzt.1 uc331tzt.1 
ENSMUST00000251830.1 ENSMUSG00000122289 ENSMUST00000251830.1 ENSMUSG00000122289 (from geneSymbol) uc331uac.1 uc331uac.1 
ENSMUST00000251831.1 ENSMUSG00000122290 ENSMUST00000251831.1 ENSMUSG00000122290 (from geneSymbol) uc331uad.1 uc331uad.1 
ENSMUST00000251833.1 ENSMUSG00000122291 ENSMUST00000251833.1 ENSMUSG00000122291 (from geneSymbol) uc331uaf.1 uc331uaf.1 
ENSMUST00000251835.1 ENSMUSG00000122292 ENSMUST00000251835.1 ENSMUSG00000122292 (from geneSymbol) uc331uah.1 uc331uah.1 
ENSMUST00000251836.1 Gm56867 ENSMUST00000251836.1 Gm56867 (from geneSymbol) uc331uai.1 uc331uai.1 
ENSMUST00000251843.1 ENSMUSG00000122293 ENSMUST00000251843.1 ENSMUSG00000122293 (from geneSymbol) uc331uap.1 uc331uap.1 
ENSMUST00000251844.1 ENSMUSG00000122294 ENSMUST00000251844.1 ENSMUSG00000122294 (from geneSymbol) AK076662 uc331uaq.1 uc331uaq.1 
ENSMUST00000251849.1 ENSMUSG00000122296 ENSMUST00000251849.1 ENSMUSG00000122296 (from geneSymbol) uc331uau.1 uc331uau.1 
ENSMUST00000251877.1 ENSMUSG00000122297 ENSMUST00000251877.1 ENSMUSG00000122297 (from geneSymbol) uc331ubw.1 uc331ubw.1 
ENSMUST00000251882.1 ENSMUSG00000122298 ENSMUST00000251882.1 ENSMUSG00000122298 (from geneSymbol) uc331ucb.1 uc331ucb.1 
ENSMUST00000251884.1 Gm13605 ENSMUST00000251884.1 Gm13605 (from geneSymbol) AK133056 uc331ucd.1 uc331ucd.1 
ENSMUST00000251888.1 ENSMUSG00000122299 ENSMUST00000251888.1 ENSMUSG00000122299 (from geneSymbol) uc331uch.1 uc331uch.1 
ENSMUST00000251890.1 Lyrm7os ENSMUST00000251890.1 Lyrm7os (from geneSymbol) AK087691 uc331ucj.1 uc331ucj.1 
ENSMUST00000251901.1 ENSMUSG00000122300 ENSMUST00000251901.1 ENSMUSG00000122300 (from geneSymbol) uc331ucu.1 uc331ucu.1 
ENSMUST00000251902.1 ENSMUSG00000122301 ENSMUST00000251902.1 ENSMUSG00000122301 (from geneSymbol) uc331ucv.1 uc331ucv.1 
ENSMUST00000251903.1 ENSMUSG00000122302 ENSMUST00000251903.1 ENSMUSG00000122302 (from geneSymbol) uc331ucw.1 uc331ucw.1 
ENSMUST00000251906.1 ENSMUSG00000122303 ENSMUST00000251906.1 ENSMUSG00000122303 (from geneSymbol) uc331ucz.1 uc331ucz.1 
ENSMUST00000251929.1 ENSMUSG00000122304 ENSMUST00000251929.1 ENSMUSG00000122304 (from geneSymbol) uc331udw.1 uc331udw.1 
ENSMUST00000251930.1 ENSMUSG00000122305 ENSMUST00000251930.1 ENSMUSG00000122305 (from geneSymbol) uc331udx.1 uc331udx.1 
ENSMUST00000251931.1 ENSMUSG00000122306 ENSMUST00000251931.1 ENSMUSG00000122306 (from geneSymbol) uc331udy.1 uc331udy.1 
ENSMUST00000251934.1 ENSMUSG00000122307 ENSMUST00000251934.1 ENSMUSG00000122307 (from geneSymbol) uc331ueb.1 uc331ueb.1 
ENSMUST00000251935.1 Gm48018 ENSMUST00000251935.1 Gm48018 (from geneSymbol) uc331uec.1 uc331uec.1 
ENSMUST00000251936.1 ENSMUSG00000122308 ENSMUST00000251936.1 ENSMUSG00000122308 (from geneSymbol) uc331ued.1 uc331ued.1 
ENSMUST00000251937.1 ENSMUSG00000122309 ENSMUST00000251937.1 ENSMUSG00000122309 (from geneSymbol) uc331uee.1 uc331uee.1 
ENSMUST00000251938.1 ENSMUSG00000122310 ENSMUST00000251938.1 ENSMUSG00000122310 (from geneSymbol) uc331uef.1 uc331uef.1 
ENSMUST00000251946.1 ENSMUSG00000122311 ENSMUST00000251946.1 ENSMUSG00000122311 (from geneSymbol) uc331uen.1 uc331uen.1 
ENSMUST00000251947.1 ENSMUSG00000122312 ENSMUST00000251947.1 ENSMUSG00000122312 (from geneSymbol) uc331ueo.1 uc331ueo.1 
ENSMUST00000251950.1 ENSMUSG00000122314 ENSMUST00000251950.1 ENSMUSG00000122314 (from geneSymbol) uc331ueq.1 uc331ueq.1 
ENSMUST00000251954.1 Gm36548 ENSMUST00000251954.1 Gm36548 (from geneSymbol) uc331ueu.1 uc331ueu.1 
ENSMUST00000251978.1 ENSMUSG00000122315 ENSMUST00000251978.1 ENSMUSG00000122315 (from geneSymbol) uc331ufr.1 uc331ufr.1 
ENSMUST00000251979.1 ENSMUSG00000122316 ENSMUST00000251979.1 ENSMUSG00000122316 (from geneSymbol) uc331ufs.1 uc331ufs.1 
ENSMUST00000251980.1 ENSMUSG00000122317 ENSMUST00000251980.1 ENSMUSG00000122317 (from geneSymbol) uc331uft.1 uc331uft.1 
ENSMUST00000251982.1 ENSMUSG00000122318 ENSMUST00000251982.1 ENSMUSG00000122318 (from geneSymbol) uc331ufv.1 uc331ufv.1 
ENSMUST00000251984.1 ENSMUSG00000122319 ENSMUST00000251984.1 ENSMUSG00000122319 (from geneSymbol) uc331ufx.1 uc331ufx.1 
ENSMUST00000251986.1 ENSMUSG00000122320 ENSMUST00000251986.1 ENSMUSG00000122320 (from geneSymbol) uc331ufz.1 uc331ufz.1 
ENSMUST00000251987.1 ENSMUSG00000122321 ENSMUST00000251987.1 ENSMUSG00000122321 (from geneSymbol) uc331uga.1 uc331uga.1 
ENSMUST00000251990.1 Gm44983 ENSMUST00000251990.1 Gm44983 (from geneSymbol) uc331ugd.1 uc331ugd.1 
ENSMUST00000252031.1 ENSMUSG00000122323 ENSMUST00000252031.1 ENSMUSG00000122323 (from geneSymbol) uc331uhr.1 uc331uhr.1 
ENSMUST00000252032.1 ENSMUSG00000122324 ENSMUST00000252032.1 ENSMUSG00000122324 (from geneSymbol) uc331uhs.1 uc331uhs.1 
ENSMUST00000252042.1 ENSMUSG00000122325 ENSMUST00000252042.1 ENSMUSG00000122325 (from geneSymbol) uc331uic.1 uc331uic.1 
ENSMUST00000252050.1 Gm57015 ENSMUST00000252050.1 Gm57015 (from geneSymbol) uc331uik.1 uc331uik.1 
ENSMUST00000252108.1 1700054K19Rik ENSMUST00000252108.1 1700054K19Rik (from geneSymbol) AK006783 uc331ukq.1 uc331ukq.1 
ENSMUST00000252117.1 ENSMUSG00000122326 ENSMUST00000252117.1 ENSMUSG00000122326 (from geneSymbol) uc331ukz.1 uc331ukz.1 
ENSMUST00000252119.1 ENSMUSG00000122327 ENSMUST00000252119.1 ENSMUSG00000122327 (from geneSymbol) uc331ula.1 uc331ula.1 
ENSMUST00000252120.1 ENSMUSG00000122328 ENSMUST00000252120.1 ENSMUSG00000122328 (from geneSymbol) uc331ulb.1 uc331ulb.1 
ENSMUST00000252121.1 Gm56514 ENSMUST00000252121.1 Gm56514 (from geneSymbol) uc331ulc.1 uc331ulc.1 
ENSMUST00000252135.1 ENSMUSG00000122329 ENSMUST00000252135.1 ENSMUSG00000122329 (from geneSymbol) uc331ulq.1 uc331ulq.1 
ENSMUST00000252137.1 ENSMUSG00000122330 ENSMUST00000252137.1 RIKEN cDNA 4933431K14 gene (from RefSeq NR_190094.1) NR_190094 uc331uls.1 uc331uls.1 
ENSMUST00000252162.1 ENSMUSG00000122331 ENSMUST00000252162.1 ENSMUSG00000122331 (from geneSymbol) uc331umr.1 uc331umr.1 
ENSMUST00000252163.1 ENSMUSG00000122332 ENSMUST00000252163.1 ENSMUSG00000122332 (from geneSymbol) uc331ums.1 uc331ums.1 
ENSMUST00000252164.1 Gm14486 ENSMUST00000252164.1 Gm14486 (from geneSymbol) uc331umt.1 uc331umt.1 
ENSMUST00000252208.1 ENSMUSG00000122333 ENSMUST00000252208.1 ENSMUSG00000122333 (from geneSymbol) uc331uol.1 uc331uol.1 
ENSMUST00000252210.1 ENSMUSG00000122334 ENSMUST00000252210.1 ENSMUSG00000122334 (from geneSymbol) uc331uon.1 uc331uon.1 
ENSMUST00000252211.1 ENSMUSG00000122335 ENSMUST00000252211.1 ENSMUSG00000122335 (from geneSymbol) uc331uoo.1 uc331uoo.1 
ENSMUST00000252230.1 ENSMUSG00000122336 ENSMUST00000252230.1 ENSMUSG00000122336 (from geneSymbol) uc331uph.1 uc331uph.1 
ENSMUST00000252231.1 ENSMUSG00000122337 ENSMUST00000252231.1 ENSMUSG00000122337 (from geneSymbol) uc331upi.1 uc331upi.1 
ENSMUST00000252234.1 ENSMUSG00000122338 ENSMUST00000252234.1 ENSMUSG00000122338 (from geneSymbol) uc331upl.1 uc331upl.1 
ENSMUST00000252237.1 ENSMUSG00000122339 ENSMUST00000252237.1 ENSMUSG00000122339 (from geneSymbol) uc331upo.1 uc331upo.1 
ENSMUST00000252239.1 ENSMUSG00000122340 ENSMUST00000252239.1 ENSMUSG00000122340 (from geneSymbol) DQ718326 uc331upq.1 uc331upq.1 
ENSMUST00000252241.1 Gm11444 ENSMUST00000252241.1 Gm11444 (from geneSymbol) uc331ups.1 uc331ups.1 
ENSMUST00000252242.1 ENSMUSG00000122341 ENSMUST00000252242.1 ENSMUSG00000122341 (from geneSymbol) uc331upt.1 uc331upt.1 
ENSMUST00000252245.1 ENSMUSG00000122342 ENSMUST00000252245.1 ENSMUSG00000122342 (from geneSymbol) uc331upw.1 uc331upw.1 
ENSMUST00000252249.1 ENSMUSG00000122343 ENSMUST00000252249.1 ENSMUSG00000122343 (from geneSymbol) uc331uqa.1 uc331uqa.1 
ENSMUST00000252250.1 ENSMUSG00000122344 ENSMUST00000252250.1 ENSMUSG00000122344 (from geneSymbol) uc331uqb.1 uc331uqb.1 
ENSMUST00000252261.1 2310015A10Rik ENSMUST00000252261.1 2310015A10Rik (from geneSymbol) AK009348 uc331uqm.1 uc331uqm.1 
ENSMUST00000252300.1 ENSMUSG00000122345 ENSMUST00000252300.1 ENSMUSG00000122345 (from geneSymbol) uc331urz.1 uc331urz.1 
ENSMUST00000252308.1 ENSMUSG00000122346 ENSMUST00000252308.1 ENSMUSG00000122346 (from geneSymbol) uc331ush.1 uc331ush.1 
ENSMUST00000252315.1 ENSMUSG00000122348 ENSMUST00000252315.1 ENSMUSG00000122348 (from geneSymbol) uc331usk.1 uc331usk.1 
ENSMUST00000252317.1 ENSMUSG00000122349 ENSMUST00000252317.1 ENSMUSG00000122349 (from geneSymbol) uc331usm.1 uc331usm.1 
ENSMUST00000252318.1 ENSMUSG00000122350 ENSMUST00000252318.1 ENSMUSG00000122350 (from geneSymbol) uc331usn.1 uc331usn.1 
ENSMUST00000252319.1 ENSMUSG00000122351 ENSMUST00000252319.1 ENSMUSG00000122351 (from geneSymbol) uc331uso.1 uc331uso.1 
ENSMUST00000252339.1 ENSMUSG00000122352 ENSMUST00000252339.1 ENSMUSG00000122352 (from geneSymbol) uc331uti.1 uc331uti.1 
ENSMUST00000252340.1 ENSMUSG00000122353 ENSMUST00000252340.1 ENSMUSG00000122353 (from geneSymbol) uc331utj.1 uc331utj.1 
ENSMUST00000252341.1 ENSMUSG00000122354 ENSMUST00000252341.1 ENSMUSG00000122354 (from geneSymbol) uc331utk.1 uc331utk.1 
ENSMUST00000252345.1 ENSMUSG00000122355 ENSMUST00000252345.1 ENSMUSG00000122355 (from geneSymbol) uc331uto.1 uc331uto.1 
ENSMUST00000252347.1 ENSMUSG00000122356 ENSMUST00000252347.1 ENSMUSG00000122356 (from geneSymbol) uc331utq.1 uc331utq.1 
ENSMUST00000252349.1 ENSMUSG00000122357 ENSMUST00000252349.1 ENSMUSG00000122357 (from geneSymbol) uc331uts.1 uc331uts.1 
ENSMUST00000252350.1 ENSMUSG00000122358 ENSMUST00000252350.1 ENSMUSG00000122358 (from geneSymbol) uc331utt.1 uc331utt.1 
ENSMUST00000252351.1 ENSMUSG00000122359 ENSMUST00000252351.1 ENSMUSG00000122359 (from geneSymbol) uc331utu.1 uc331utu.1 
ENSMUST00000252357.1 Gm15485 ENSMUST00000252357.1 Gm15485 (from geneSymbol) uc331uua.1 uc331uua.1 
ENSMUST00000252358.1 ENSMUSG00000122360 ENSMUST00000252358.1 ENSMUSG00000122360 (from geneSymbol) uc331uub.1 uc331uub.1 
ENSMUST00000252359.1 Gm11542 ENSMUST00000252359.1 Gm11542 (from geneSymbol) AK030524 uc331uuc.1 uc331uuc.1 
ENSMUST00000252360.1 ENSMUSG00000122361 ENSMUST00000252360.1 ENSMUSG00000122361 (from geneSymbol) uc331uud.1 uc331uud.1 
ENSMUST00000252362.1 ENSMUSG00000122362 ENSMUST00000252362.1 ENSMUSG00000122362 (from geneSymbol) uc331uuf.1 uc331uuf.1 
ENSMUST00000252363.1 ENSMUSG00000122363 ENSMUST00000252363.1 ENSMUSG00000122363 (from geneSymbol) uc331uug.1 uc331uug.1 
ENSMUST00000252364.1 ENSMUSG00000122364 ENSMUST00000252364.1 ENSMUSG00000122364 (from geneSymbol) uc331uuh.1 uc331uuh.1 
ENSMUST00000252368.1 ENSMUSG00000122365 ENSMUST00000252368.1 ENSMUSG00000122365 (from geneSymbol) uc331uul.1 uc331uul.1 
ENSMUST00000252369.1 Gm11635 ENSMUST00000252369.1 Gm11635 (from geneSymbol) BC048585 uc331uum.1 uc331uum.1 
ENSMUST00000252382.1 ENSMUSG00000122366 ENSMUST00000252382.1 ENSMUSG00000122366 (from geneSymbol) uc331uuz.1 uc331uuz.1 
ENSMUST00000252387.1 Gm26788 ENSMUST00000252387.1 Gm26788 (from geneSymbol) AK043860 uc331uve.1 uc331uve.1 
ENSMUST00000252389.1 ENSMUSG00000122367 ENSMUST00000252389.1 ENSMUSG00000122367 (from geneSymbol) uc331uvg.1 uc331uvg.1 
ENSMUST00000252401.1 ENSMUSG00000122368 ENSMUST00000252401.1 ENSMUSG00000122368 (from geneSymbol) uc331uvs.1 uc331uvs.1 
ENSMUST00000252403.1 ENSMUSG00000122369 ENSMUST00000252403.1 ENSMUSG00000122369 (from geneSymbol) uc331uvu.1 uc331uvu.1 
ENSMUST00000252409.1 ENSMUSG00000122370 ENSMUST00000252409.1 ENSMUSG00000122370 (from geneSymbol) uc331uwa.1 uc331uwa.1 
ENSMUST00000252419.1 ENSMUSG00000122371 ENSMUST00000252419.1 ENSMUSG00000122371 (from geneSymbol) uc331uwk.1 uc331uwk.1 
ENSMUST00000252455.1 ENSMUSG00000122372 ENSMUST00000252455.1 ENSMUSG00000122372 (from geneSymbol) uc331uxu.1 uc331uxu.1 
ENSMUST00000252479.1 ENSMUSG00000122374 ENSMUST00000252479.1 ENSMUSG00000122374 (from geneSymbol) uc331uyk.1 uc331uyk.1 
ENSMUST00000252481.1 Gm57111 ENSMUST00000252481.1 Gm57111 (from geneSymbol) uc331uym.1 uc331uym.1 
ENSMUST00000252485.1 ENSMUSG00000122375 ENSMUST00000252485.1 ENSMUSG00000122375 (from geneSymbol) uc331uyq.1 uc331uyq.1 
ENSMUST00000252491.1 4930565D16Rik ENSMUST00000252491.1 4930565D16Rik (from geneSymbol) AK016226 uc331uyw.1 uc331uyw.1 
ENSMUST00000252508.1 ENSMUSG00000122376 ENSMUST00000252508.1 ENSMUSG00000122376 (from geneSymbol) uc331uzn.1 uc331uzn.1 
ENSMUST00000252509.1 ENSMUSG00000122377 ENSMUST00000252509.1 ENSMUSG00000122377 (from geneSymbol) uc331uzo.1 uc331uzo.1 
ENSMUST00000252511.1 ENSMUSG00000122378 ENSMUST00000252511.1 ENSMUSG00000122378 (from geneSymbol) uc331uzq.1 uc331uzq.1 
ENSMUST00000252512.1 ENSMUSG00000122379 ENSMUST00000252512.1 ENSMUSG00000122379 (from geneSymbol) uc331uzr.1 uc331uzr.1 
ENSMUST00000252513.1 ENSMUSG00000122380 ENSMUST00000252513.1 ENSMUSG00000122380 (from geneSymbol) uc331uzs.1 uc331uzs.1 
ENSMUST00000252515.1 2310005E17Rik ENSMUST00000252515.1 2310005E17Rik (from geneSymbol) AK009168 uc331uzu.1 uc331uzu.1 
ENSMUST00000252522.1 ENSMUSG00000122381 ENSMUST00000252522.1 ENSMUSG00000122381 (from geneSymbol) uc331vab.1 uc331vab.1 
ENSMUST00000252545.1 ENSMUSG00000122382 ENSMUST00000252545.1 ENSMUSG00000122382 (from geneSymbol) uc331vay.1 uc331vay.1 
ENSMUST00000252546.1 ENSMUSG00000122383 ENSMUST00000252546.1 ENSMUSG00000122383 (from geneSymbol) uc331vaz.1 uc331vaz.1 
ENSMUST00000252547.1 Gm4632 ENSMUST00000252547.1 Gm4632 (from geneSymbol) BC027670 uc331vba.1 uc331vba.1 
ENSMUST00000252557.1 1300014J16Rik ENSMUST00000252557.1 1300014J16Rik (from geneSymbol) uc331vbk.1 uc331vbk.1 
ENSMUST00000252567.1 ENSMUSG00000122384 ENSMUST00000252567.1 ENSMUSG00000122384 (from geneSymbol) uc331vbu.1 uc331vbu.1 
ENSMUST00000252570.1 ENSMUSG00000122385 ENSMUST00000252570.1 ENSMUSG00000122385 (from geneSymbol) uc331vbx.1 uc331vbx.1 
ENSMUST00000252576.1 ENSMUSG00000122387 ENSMUST00000252576.1 ENSMUSG00000122387 (from geneSymbol) uc331vcb.1 uc331vcb.1 
ENSMUST00000252579.1 ENSMUSG00000122388 ENSMUST00000252579.1 ENSMUSG00000122388 (from geneSymbol) uc331vce.1 uc331vce.1 
ENSMUST00000252580.1 Gm12144 ENSMUST00000252580.1 Gm12144 (from geneSymbol) AK087644 uc331vcf.1 uc331vcf.1 
ENSMUST00000252582.1 ENSMUSG00000122389 ENSMUST00000252582.1 ENSMUSG00000122389 (from geneSymbol) uc331vch.1 uc331vch.1 
ENSMUST00000252583.1 ENSMUSG00000122390 ENSMUST00000252583.1 ENSMUSG00000122390 (from geneSymbol) uc331vci.1 uc331vci.1 
ENSMUST00000252589.1 Gm48917 ENSMUST00000252589.1 Gm48917 (from geneSymbol) uc331vco.1 uc331vco.1 
ENSMUST00000252594.1 ENSMUSG00000122391 ENSMUST00000252594.1 ENSMUSG00000122391 (from geneSymbol) uc331vct.1 uc331vct.1 
ENSMUST00000252598.1 ENSMUSG00000122392 ENSMUST00000252598.1 ENSMUSG00000122392 (from geneSymbol) uc331vcx.1 uc331vcx.1 
ENSMUST00000252614.1 Gm31172 ENSMUST00000252614.1 Gm31172 (from geneSymbol) uc331vdn.1 uc331vdn.1 
ENSMUST00000252618.1 ENSMUSG00000122393 ENSMUST00000252618.1 ENSMUSG00000122393 (from geneSymbol) uc331vdr.1 uc331vdr.1 
ENSMUST00000252621.1 ENSMUSG00000122394 ENSMUST00000252621.1 ENSMUSG00000122394 (from geneSymbol) uc331vdu.1 uc331vdu.1 
ENSMUST00000252625.1 ENSMUSG00000122395 ENSMUST00000252625.1 ENSMUSG00000122395 (from geneSymbol) uc331vdy.1 uc331vdy.1 
ENSMUST00000252627.1 ENSMUSG00000122396 ENSMUST00000252627.1 ENSMUSG00000122396 (from geneSymbol) AK050117 uc331vea.1 uc331vea.1 
ENSMUST00000252633.1 ENSMUSG00000122397 ENSMUST00000252633.1 ENSMUSG00000122397 (from geneSymbol) uc331veg.1 uc331veg.1 
ENSMUST00000252635.1 ENSMUSG00000122399 ENSMUST00000252635.1 ENSMUSG00000122399 (from geneSymbol) uc331veh.1 uc331veh.1 
ENSMUST00000252637.1 1500004A13Rik ENSMUST00000252637.1 1500004A13Rik (from geneSymbol) AK078122 uc331vej.1 uc331vej.1 
ENSMUST00000252670.1 Mir205hg ENSMUST00000252670.1 Mir205hg (from geneSymbol) AK014513 uc331vfq.1 uc331vfq.1 
ENSMUST00000252671.1 ENSMUSG00000122400 ENSMUST00000252671.1 ENSMUSG00000122400 (from geneSymbol) uc331vfr.1 uc331vfr.1 
ENSMUST00000252672.1 ENSMUSG00000122401 ENSMUST00000252672.1 ENSMUSG00000122401 (from geneSymbol) uc331vfs.1 uc331vfs.1 
ENSMUST00000252681.1 ENSMUSG00000122402 ENSMUST00000252681.1 ENSMUSG00000122402 (from geneSymbol) uc331vgb.1 uc331vgb.1 
ENSMUST00000252682.1 ENSMUSG00000122403 ENSMUST00000252682.1 ENSMUSG00000122403 (from geneSymbol) uc331vgc.1 uc331vgc.1 
ENSMUST00000252683.1 1810010K12Rik ENSMUST00000252683.1 1810010K12Rik (from geneSymbol) uc331vgd.1 uc331vgd.1 
ENSMUST00000252689.1 ENSMUSG00000122404 ENSMUST00000252689.1 ENSMUSG00000122404 (from geneSymbol) uc331vgj.1 uc331vgj.1 
ENSMUST00000252693.1 Gm13017 ENSMUST00000252693.1 Gm13017 (from geneSymbol) uc331vgn.1 uc331vgn.1 
ENSMUST00000252701.1 Gm40627 ENSMUST00000252701.1 Gm40627 (from geneSymbol) uc331vgv.1 uc331vgv.1 
ENSMUST00000252712.1 4930533I22Rik ENSMUST00000252712.1 4930533I22Rik (from geneSymbol) AK015214 uc331vhg.1 uc331vhg.1 
ENSMUST00000252859.1 ENSMUSG00000122406 ENSMUST00000252859.1 ENSMUSG00000122406 (from geneSymbol) uc331vmt.1 uc331vmt.1 
ENSMUST00000252861.1 ENSMUSG00000122407 ENSMUST00000252861.1 ENSMUSG00000122407 (from geneSymbol) uc331vmv.1 uc331vmv.1 
ENSMUST00000252862.1 ENSMUSG00000122408 ENSMUST00000252862.1 ENSMUSG00000122408 (from geneSymbol) uc331vmw.1 uc331vmw.1 
ENSMUST00000252876.1 ENSMUSG00000122409 ENSMUST00000252876.1 ENSMUSG00000122409 (from geneSymbol) uc331vnk.1 uc331vnk.1 
ENSMUST00000252878.1 ENSMUSG00000122410 ENSMUST00000252878.1 ENSMUSG00000122410 (from geneSymbol) uc331vnm.1 uc331vnm.1 
ENSMUST00000252894.1 Gm27042 ENSMUST00000252894.1 Gm27042 (from geneSymbol) AK155612 uc331voc.1 uc331voc.1 
ENSMUST00000252900.1 ENSMUSG00000122411 ENSMUST00000252900.1 ENSMUSG00000122411 (from geneSymbol) uc331voi.1 uc331voi.1 
ENSMUST00000252902.1 Gm56530 ENSMUST00000252902.1 Gm56530 (from geneSymbol) uc331vok.1 uc331vok.1 
ENSMUST00000252914.1 ENSMUSG00000122412 ENSMUST00000252914.1 ENSMUSG00000122412 (from geneSymbol) uc331vow.1 uc331vow.1 
ENSMUST00000252925.1 ENSMUSG00000122413 ENSMUST00000252925.1 ENSMUSG00000122413 (from geneSymbol) uc331vph.1 uc331vph.1 
ENSMUST00000252949.1 ENSMUSG00000122414 ENSMUST00000252949.1 ENSMUSG00000122414 (from geneSymbol) uc331vqf.1 uc331vqf.1 
ENSMUST00000252951.1 ENSMUSG00000122415 ENSMUST00000252951.1 ENSMUSG00000122415 (from geneSymbol) uc331vqh.1 uc331vqh.1 
ENSMUST00000252955.1 A830052D11Rik ENSMUST00000252955.1 A830052D11Rik (from geneSymbol) AK043919 uc331vql.1 uc331vql.1 
ENSMUST00000252989.1 ENSMUSG00000122416 ENSMUST00000252989.1 ENSMUSG00000122416 (from geneSymbol) uc331vrt.1 uc331vrt.1 
ENSMUST00000252995.1 ENSMUSG00000122417 ENSMUST00000252995.1 ENSMUSG00000122417 (from geneSymbol) uc331vrz.1 uc331vrz.1 
ENSMUST00000252996.1 ENSMUSG00000122418 ENSMUST00000252996.1 ENSMUSG00000122418 (from geneSymbol) uc331vsa.1 uc331vsa.1 
ENSMUST00000252997.1 ENSMUSG00000122419 ENSMUST00000252997.1 ENSMUSG00000122419 (from geneSymbol) uc331vsb.1 uc331vsb.1 
ENSMUST00000253000.1 ENSMUSG00000122421 ENSMUST00000253000.1 ENSMUSG00000122421 (from geneSymbol) uc331vsd.1 uc331vsd.1 
ENSMUST00000253001.1 ENSMUSG00000122422 ENSMUST00000253001.1 ENSMUSG00000122422 (from geneSymbol) uc331vse.1 uc331vse.1 
ENSMUST00000253004.1 4933429K18Rik ENSMUST00000253004.1 4933429K18Rik (from geneSymbol) AK016983 uc331vsh.1 uc331vsh.1 
ENSMUST00000253019.1 ENSMUSG00000122424 ENSMUST00000253019.1 ENSMUSG00000122424 (from geneSymbol) uc331vsw.1 uc331vsw.1 
ENSMUST00000253025.1 ENSMUSG00000122425 ENSMUST00000253025.1 ENSMUSG00000122425 (from geneSymbol) uc331vtc.1 uc331vtc.1 
ENSMUST00000253026.1 ENSMUSG00000122426 ENSMUST00000253026.1 ENSMUSG00000122426 (from geneSymbol) uc331vtd.1 uc331vtd.1 
ENSMUST00000253027.1 ENSMUSG00000122427 ENSMUST00000253027.1 ENSMUSG00000122427 (from geneSymbol) uc331vte.1 uc331vte.1 
ENSMUST00000253030.1 Gm28821 ENSMUST00000253030.1 Gm28821 (from geneSymbol) uc331vth.1 uc331vth.1 
ENSMUST00000253037.1 ENSMUSG00000122428 ENSMUST00000253037.1 predicted gene, 52298, transcript variant 5 (from RefSeq NR_169106.1) NR_169106 uc331vtm.1 uc331vtm.1 
ENSMUST00000253042.1 ENSMUSG00000122429 ENSMUST00000253042.1 ENSMUSG00000122429 (from geneSymbol) uc331vtp.1 uc331vtp.1 
ENSMUST00000253046.1 ENSMUSG00000122430 ENSMUST00000253046.1 ENSMUSG00000122430 (from geneSymbol) uc331vtt.1 uc331vtt.1 
ENSMUST00000253047.1 ENSMUSG00000122431 ENSMUST00000253047.1 ENSMUSG00000122431 (from geneSymbol) uc331vtu.1 uc331vtu.1 
ENSMUST00000253049.1 4930511P09Rik ENSMUST00000253049.1 uncharacterized LOC102637792, transcript variant 1 (from RefSeq NR_168703.1) NR_168703 uc331vtw.1 uc331vtw.1 
ENSMUST00000253067.1 ENSMUSG00000122433 ENSMUST00000253067.1 ENSMUSG00000122433 (from geneSymbol) uc331vuo.1 uc331vuo.1 
ENSMUST00000253069.1 ENSMUSG00000122434 ENSMUST00000253069.1 ENSMUSG00000122434 (from geneSymbol) uc331vuq.1 uc331vuq.1 
ENSMUST00000253079.1 ENSMUSG00000122435 ENSMUST00000253079.1 ENSMUSG00000122435 (from geneSymbol) uc331vva.1 uc331vva.1 
ENSMUST00000253080.1 Gm13112 ENSMUST00000253080.1 Gm13112 (from geneSymbol) AK030206 uc331vvb.1 uc331vvb.1 
ENSMUST00000253084.1 ENSMUSG00000122436 ENSMUST00000253084.1 ENSMUSG00000122436 (from geneSymbol) uc331vvf.1 uc331vvf.1 
ENSMUST00000253088.1 ENSMUSG00000122438 ENSMUST00000253088.1 ENSMUSG00000122438 (from geneSymbol) uc331vvi.1 uc331vvi.1 
ENSMUST00000253093.1 ENSMUSG00000122439 ENSMUST00000253093.1 ENSMUSG00000122439 (from geneSymbol) uc331vvn.1 uc331vvn.1 
ENSMUST00000253094.1 ENSMUSG00000122440 ENSMUST00000253094.1 ENSMUSG00000122440 (from geneSymbol) AK005385 uc331vvo.1 uc331vvo.1 
ENSMUST00000253131.1 ENSMUSG00000122441 ENSMUST00000253131.1 ENSMUSG00000122441 (from geneSymbol) uc331vww.1 uc331vww.1 
ENSMUST00000253134.1 ENSMUSG00000122442 ENSMUST00000253134.1 ENSMUSG00000122442 (from geneSymbol) uc331vwz.1 uc331vwz.1 
ENSMUST00000253135.1 ENSMUSG00000122443 ENSMUST00000253135.1 ENSMUSG00000122443 (from geneSymbol) uc331vxa.1 uc331vxa.1 
ENSMUST00000253139.1 ENSMUSG00000122444 ENSMUST00000253139.1 ENSMUSG00000122444 (from geneSymbol) uc331vxe.1 uc331vxe.1 
ENSMUST00000253161.1 ENSMUSG00000122445 ENSMUST00000253161.1 ENSMUSG00000122445 (from geneSymbol) uc331vya.1 uc331vya.1 
ENSMUST00000253163.1 ENSMUSG00000122446 ENSMUST00000253163.1 ENSMUSG00000122446 (from geneSymbol) uc331vyc.1 uc331vyc.1 
ENSMUST00000253173.1 ENSMUSG00000122447 ENSMUST00000253173.1 ENSMUSG00000122447 (from geneSymbol) uc331vym.1 uc331vym.1 
ENSMUST00000253186.1 ENSMUSG00000122448 ENSMUST00000253186.1 ENSMUSG00000122448 (from geneSymbol) uc331vyz.1 uc331vyz.1 
ENSMUST00000253187.1 ENSMUSG00000122449 ENSMUST00000253187.1 ENSMUSG00000122449 (from geneSymbol) uc331vza.1 uc331vza.1 
ENSMUST00000253188.1 ENSMUSG00000122450 ENSMUST00000253188.1 ENSMUSG00000122450 (from geneSymbol) uc331vzb.1 uc331vzb.1 
ENSMUST00000253190.1 ENSMUSG00000122451 ENSMUST00000253190.1 ENSMUSG00000122451 (from geneSymbol) uc331vzd.1 uc331vzd.1 
ENSMUST00000253192.1 ENSMUSG00000122452 ENSMUST00000253192.1 ENSMUSG00000122452 (from geneSymbol) uc331vzf.1 uc331vzf.1 
ENSMUST00000253195.1 ENSMUSG00000122453 ENSMUST00000253195.1 ENSMUSG00000122453 (from geneSymbol) uc331vzh.1 uc331vzh.1 
ENSMUST00000253198.1 ENSMUSG00000122454 ENSMUST00000253198.1 ENSMUSG00000122454 (from geneSymbol) uc331vzk.1 uc331vzk.1 
ENSMUST00000253200.1 ENSMUSG00000122455 ENSMUST00000253200.1 ENSMUSG00000122455 (from geneSymbol) uc331vzm.1 uc331vzm.1 
ENSMUST00000253204.1 ENSMUSG00000122456 ENSMUST00000253204.1 ENSMUSG00000122456 (from geneSymbol) uc331vzq.1 uc331vzq.1 
ENSMUST00000253208.1 ENSMUSG00000122457 ENSMUST00000253208.1 ENSMUSG00000122457 (from geneSymbol) uc331vzu.1 uc331vzu.1 
ENSMUST00000253213.1 ENSMUSG00000122458 ENSMUST00000253213.1 ENSMUSG00000122458 (from geneSymbol) uc331vzz.1 uc331vzz.1 
ENSMUST00000253218.1 ENSMUSG00000122459 ENSMUST00000253218.1 ENSMUSG00000122459 (from geneSymbol) uc331wae.1 uc331wae.1 
ENSMUST00000253233.1 ENSMUSG00000122460 ENSMUST00000253233.1 ENSMUSG00000122460 (from geneSymbol) uc331wat.1 uc331wat.1 
ENSMUST00000253234.1 ENSMUSG00000122461 ENSMUST00000253234.1 ENSMUSG00000122461 (from geneSymbol) uc331wau.1 uc331wau.1 
ENSMUST00000253236.1 ENSMUSG00000122462 ENSMUST00000253236.1 ENSMUSG00000122462 (from geneSymbol) uc331waw.1 uc331waw.1 
ENSMUST00000253238.1 ENSMUSG00000122463 ENSMUST00000253238.1 ENSMUSG00000122463 (from geneSymbol) uc331way.1 uc331way.1 
ENSMUST00000253239.1 1700015C15Rik ENSMUST00000253239.1 1700015C15Rik (from geneSymbol) AK005986 uc331waz.1 uc331waz.1 
ENSMUST00000253255.1 ENSMUSG00000122464 ENSMUST00000253255.1 ENSMUSG00000122464 (from geneSymbol) uc331wbp.1 uc331wbp.1 
ENSMUST00000253256.1 ENSMUSG00000122465 ENSMUST00000253256.1 ENSMUSG00000122465 (from geneSymbol) uc331wbq.1 uc331wbq.1 
ENSMUST00000253259.1 Gm14144 ENSMUST00000253259.1 Gm14144 (from geneSymbol) uc331wbt.1 uc331wbt.1 
ENSMUST00000253303.1 ENSMUSG00000122467 ENSMUST00000253303.1 ENSMUSG00000122467 (from geneSymbol) uc331wdk.1 uc331wdk.1 
ENSMUST00000253306.1 ENSMUSG00000122468 ENSMUST00000253306.1 ENSMUSG00000122468 (from geneSymbol) uc331wdn.1 uc331wdn.1 
ENSMUST00000253307.1 ENSMUSG00000122469 ENSMUST00000253307.1 ENSMUSG00000122469 (from geneSymbol) uc331wdo.1 uc331wdo.1 
ENSMUST00000253308.1 ENSMUSG00000122470 ENSMUST00000253308.1 ENSMUSG00000122470 (from geneSymbol) uc331wdp.1 uc331wdp.1 
ENSMUST00000253310.1 ENSMUSG00000122471 ENSMUST00000253310.1 ENSMUSG00000122471 (from geneSymbol) uc331wdr.1 uc331wdr.1 
ENSMUST00000253312.1 Gm15326 ENSMUST00000253312.1 Gm15326 (from geneSymbol) uc331wdt.1 uc331wdt.1 
ENSMUST00000253315.1 ENSMUSG00000122472 ENSMUST00000253315.1 ENSMUSG00000122472 (from geneSymbol) uc331wdw.1 uc331wdw.1 
ENSMUST00000253318.1 ENSMUSG00000122473 ENSMUST00000253318.1 ENSMUSG00000122473 (from geneSymbol) uc331wdz.1 uc331wdz.1 
ENSMUST00000253320.1 ENSMUSG00000122474 ENSMUST00000253320.1 ENSMUSG00000122474 (from geneSymbol) uc331web.1 uc331web.1 
ENSMUST00000253325.1 ENSMUSG00000122475 ENSMUST00000253325.1 ENSMUSG00000122475 (from geneSymbol) uc331weg.1 uc331weg.1 
ENSMUST00000253326.1 Dreg1 ENSMUST00000253326.1 Dreg1 (from geneSymbol) AK080422 uc331weh.1 uc331weh.1 
ENSMUST00000253327.1 Gm46878 ENSMUST00000253327.1 Gm46878 (from geneSymbol) uc331wei.1 uc331wei.1 
ENSMUST00000253328.1 ENSMUSG00000122476 ENSMUST00000253328.1 ENSMUSG00000122476 (from geneSymbol) uc331wej.1 uc331wej.1 
ENSMUST00000253329.1 ENSMUSG00000122477 ENSMUST00000253329.1 ENSMUSG00000122477 (from geneSymbol) uc331wek.1 uc331wek.1 
ENSMUST00000253338.1 ENSMUSG00000122479 ENSMUST00000253338.1 ENSMUSG00000122479 (from geneSymbol) uc331wer.1 uc331wer.1 
ENSMUST00000253340.1 ENSMUSG00000122480 ENSMUST00000253340.1 ENSMUSG00000122480 (from geneSymbol) uc331wet.1 uc331wet.1 
ENSMUST00000253343.1 ENSMUSG00000122481 ENSMUST00000253343.1 ENSMUSG00000122481 (from geneSymbol) uc331wew.1 uc331wew.1 
ENSMUST00000253352.1 ENSMUSG00000122482 ENSMUST00000253352.1 ENSMUSG00000122482 (from geneSymbol) uc331wff.1 uc331wff.1 
ENSMUST00000253355.1 ENSMUSG00000122483 ENSMUST00000253355.1 ENSMUSG00000122483 (from geneSymbol) uc331wfi.1 uc331wfi.1 
ENSMUST00000253356.1 ENSMUSG00000122484 ENSMUST00000253356.1 ENSMUSG00000122484 (from geneSymbol) BC059914 uc331wfj.1 uc331wfj.1 
ENSMUST00000253359.1 ENSMUSG00000122485 ENSMUST00000253359.1 ENSMUSG00000122485 (from geneSymbol) uc331wfm.1 uc331wfm.1 
ENSMUST00000253360.1 ENSMUSG00000122486 ENSMUST00000253360.1 ENSMUSG00000122486 (from geneSymbol) uc331wfn.1 uc331wfn.1 
ENSMUST00000253361.1 ENSMUSG00000122487 ENSMUST00000253361.1 ENSMUSG00000122487 (from geneSymbol) AK041227 uc331wfo.1 uc331wfo.1 
ENSMUST00000253362.1 Gm20501 ENSMUST00000253362.1 Gm20501 (from geneSymbol) uc331wfp.1 uc331wfp.1 
ENSMUST00000253377.1 ENSMUSG00000122489 ENSMUST00000253377.1 ENSMUSG00000122489 (from geneSymbol) uc331wgd.1 uc331wgd.1 
ENSMUST00000253378.1 ENSMUSG00000122490 ENSMUST00000253378.1 ENSMUSG00000122490 (from geneSymbol) uc331wge.1 uc331wge.1 
ENSMUST00000253384.1 ENSMUSG00000122491 ENSMUST00000253384.1 ENSMUSG00000122491 (from geneSymbol) uc331wgk.1 uc331wgk.1 
ENSMUST00000253386.1 ENSMUSG00000122492 ENSMUST00000253386.1 ENSMUSG00000122492 (from geneSymbol) uc331wgm.1 uc331wgm.1 
ENSMUST00000253387.1 ENSMUSG00000122493 ENSMUST00000253387.1 ENSMUSG00000122493 (from geneSymbol) uc331wgn.1 uc331wgn.1 
ENSMUST00000253388.1 ENSMUSG00000122494 ENSMUST00000253388.1 ENSMUSG00000122494 (from geneSymbol) LF200886 uc331wgo.1 uc331wgo.1 
ENSMUST00000253391.1 ENSMUSG00000122495 ENSMUST00000253391.1 ENSMUSG00000122495 (from geneSymbol) uc331wgr.1 uc331wgr.1 
ENSMUST00000253392.1 ENSMUSG00000122496 ENSMUST00000253392.1 ENSMUSG00000122496 (from geneSymbol) uc331wgs.1 uc331wgs.1 
ENSMUST00000253393.1 Gm14161 ENSMUST00000253393.1 predicted gene 14161 (from RefSeq NR_166456.1) NR_166456 uc331wgt.1 uc331wgt.1 
ENSMUST00000253402.1 Gm56730 ENSMUST00000253402.1 Gm56730 (from geneSymbol) uc331whc.1 uc331whc.1 
ENSMUST00000253407.1 ENSMUSG00000122497 ENSMUST00000253407.1 ENSMUSG00000122497 (from geneSymbol) uc331whh.1 uc331whh.1 
ENSMUST00000253408.1 Gm42920 ENSMUST00000253408.1 Gm42920 (from geneSymbol) uc331whi.1 uc331whi.1 
ENSMUST00000253414.1 ENSMUSG00000122499 ENSMUST00000253414.1 ENSMUSG00000122499 (from geneSymbol) uc331whn.1 uc331whn.1 
ENSMUST00000253419.1 ENSMUSG00000122500 ENSMUST00000253419.1 ENSMUSG00000122500 (from geneSymbol) uc331whs.1 uc331whs.1 
ENSMUST00000253420.1 ENSMUSG00000122501 ENSMUST00000253420.1 ENSMUSG00000122501 (from geneSymbol) uc331wht.1 uc331wht.1 
ENSMUST00000253421.1 ENSMUSG00000122502 ENSMUST00000253421.1 ENSMUSG00000122502 (from geneSymbol) uc331whu.1 uc331whu.1 
ENSMUST00000253422.1 ENSMUSG00000122503 ENSMUST00000253422.1 ENSMUSG00000122503 (from geneSymbol) uc331whv.1 uc331whv.1 
ENSMUST00000253424.1 ENSMUSG00000122504 ENSMUST00000253424.1 ENSMUSG00000122504 (from geneSymbol) uc331whx.1 uc331whx.1 
ENSMUST00000253427.1 ENSMUSG00000122505 ENSMUST00000253427.1 ENSMUSG00000122505 (from geneSymbol) uc331wia.1 uc331wia.1 
ENSMUST00000253429.1 Gm2885 ENSMUST00000253429.1 Gm2885 (from geneSymbol) AK037830 uc331wic.1 uc331wic.1 
ENSMUST00000253439.1 ENSMUSG00000122506 ENSMUST00000253439.1 ENSMUSG00000122506 (from geneSymbol) uc331wim.1 uc331wim.1 
ENSMUST00000253442.1 ENSMUSG00000122507 ENSMUST00000253442.1 ENSMUSG00000122507 (from geneSymbol) uc331wip.1 uc331wip.1 
ENSMUST00000253443.1 ENSMUSG00000122508 ENSMUST00000253443.1 ENSMUSG00000122508 (from geneSymbol) uc331wiq.1 uc331wiq.1 
ENSMUST00000253445.1 ENSMUSG00000122509 ENSMUST00000253445.1 ENSMUSG00000122509 (from geneSymbol) uc331wis.1 uc331wis.1 
ENSMUST00000253446.1 ENSMUSG00000122510 ENSMUST00000253446.1 ENSMUSG00000122510 (from geneSymbol) uc331wit.1 uc331wit.1 
ENSMUST00000253449.1 ENSMUSG00000122511 ENSMUST00000253449.1 ENSMUSG00000122511 (from geneSymbol) uc331wiw.1 uc331wiw.1 
ENSMUST00000253450.1 ENSMUSG00000122512 ENSMUST00000253450.1 ENSMUSG00000122512 (from geneSymbol) uc331wix.1 uc331wix.1 
ENSMUST00000253451.1 ENSMUSG00000122513 ENSMUST00000253451.1 ENSMUSG00000122513 (from geneSymbol) uc331wiy.1 uc331wiy.1 
ENSMUST00000253453.1 ENSMUSG00000122514 ENSMUST00000253453.1 ENSMUSG00000122514 (from geneSymbol) uc331wja.1 uc331wja.1 
ENSMUST00000253455.1 ENSMUSG00000122515 ENSMUST00000253455.1 ENSMUSG00000122515 (from geneSymbol) uc331wjc.1 uc331wjc.1 
ENSMUST00000253456.1 ENSMUSG00000122516 ENSMUST00000253456.1 ENSMUSG00000122516 (from geneSymbol) uc331wjd.1 uc331wjd.1 
ENSMUST00000253457.1 ENSMUSG00000122517 ENSMUST00000253457.1 ENSMUSG00000122517 (from geneSymbol) uc331wje.1 uc331wje.1 
ENSMUST00000253458.1 ENSMUSG00000122518 ENSMUST00000253458.1 ENSMUSG00000122518 (from geneSymbol) uc331wjf.1 uc331wjf.1 
ENSMUST00000253462.1 Gm32305 ENSMUST00000253462.1 Gm32305 (from geneSymbol) uc331wjj.1 uc331wjj.1 
ENSMUST00000253469.1 ENSMUSG00000122519 ENSMUST00000253469.1 ENSMUSG00000122519 (from geneSymbol) uc331wjq.1 uc331wjq.1 
ENSMUST00000253471.1 ENSMUSG00000122520 ENSMUST00000253471.1 ENSMUSG00000122520 (from geneSymbol) uc331wjs.1 uc331wjs.1 
ENSMUST00000253472.1 ENSMUSG00000122521 ENSMUST00000253472.1 ENSMUSG00000122521 (from geneSymbol) uc331wjt.1 uc331wjt.1 
ENSMUST00000253473.1 ENSMUSG00000122522 ENSMUST00000253473.1 ENSMUSG00000122522 (from geneSymbol) KY468182 uc331wju.1 uc331wju.1 
ENSMUST00000253480.1 ENSMUSG00000122523 ENSMUST00000253480.1 ENSMUSG00000122523 (from geneSymbol) uc331wkb.1 uc331wkb.1 
ENSMUST00000253482.1 ENSMUSG00000122524 ENSMUST00000253482.1 ENSMUSG00000122524 (from geneSymbol) uc331wkd.1 uc331wkd.1 
ENSMUST00000253484.1 ENSMUSG00000122525 ENSMUST00000253484.1 ENSMUSG00000122525 (from geneSymbol) uc331wkf.1 uc331wkf.1 
ENSMUST00000253485.1 ENSMUSG00000122526 ENSMUST00000253485.1 ENSMUSG00000122526 (from geneSymbol) uc331wkg.1 uc331wkg.1 
ENSMUST00000253487.1 Gm50242 ENSMUST00000253487.1 Gm50242 (from geneSymbol) uc331wki.1 uc331wki.1 
ENSMUST00000253501.1 ENSMUSG00000122527 ENSMUST00000253501.1 ENSMUSG00000122527 (from geneSymbol) uc331wkw.1 uc331wkw.1 
ENSMUST00000253502.1 ENSMUSG00000122528 ENSMUST00000253502.1 ENSMUSG00000122528 (from geneSymbol) uc331wkx.1 uc331wkx.1 
ENSMUST00000253503.1 ENSMUSG00000122529 ENSMUST00000253503.1 ENSMUSG00000122529 (from geneSymbol) KY468240 uc331wky.1 uc331wky.1 
ENSMUST00000253519.1 ENSMUSG00000122530 ENSMUST00000253519.1 ENSMUSG00000122530 (from geneSymbol) uc331wln.1 uc331wln.1 
ENSMUST00000253520.1 ENSMUSG00000122531 ENSMUST00000253520.1 ENSMUSG00000122531 (from geneSymbol) uc331wlo.1 uc331wlo.1 
ENSMUST00000253522.1 ENSMUSG00000122532 ENSMUST00000253522.1 ENSMUSG00000122532 (from geneSymbol) uc331wlq.1 uc331wlq.1 
ENSMUST00000253523.1 ENSMUSG00000122533 ENSMUST00000253523.1 ENSMUSG00000122533 (from geneSymbol) uc331wlr.1 uc331wlr.1 
ENSMUST00000253524.1 ENSMUSG00000122534 ENSMUST00000253524.1 ENSMUSG00000122534 (from geneSymbol) uc331wls.1 uc331wls.1 
ENSMUST00000253532.1 ENSMUSG00000122535 ENSMUST00000253532.1 ENSMUSG00000122535 (from geneSymbol) uc331wma.1 uc331wma.1 
ENSMUST00000253533.1 ENSMUSG00000122536 ENSMUST00000253533.1 ENSMUSG00000122536 (from geneSymbol) uc331wmb.1 uc331wmb.1 
ENSMUST00000253538.1 Gm41664 ENSMUST00000253538.1 Gm41664 (from geneSymbol) AK020087 uc331wmg.1 uc331wmg.1 
ENSMUST00000253549.1 ENSMUSG00000122537 ENSMUST00000253549.1 ENSMUSG00000122537 (from geneSymbol) uc331wmr.1 uc331wmr.1 
ENSMUST00000253550.1 ENSMUSG00000122538 ENSMUST00000253550.1 ENSMUSG00000122538 (from geneSymbol) uc331wms.1 uc331wms.1 
ENSMUST00000253551.1 ENSMUSG00000122539 ENSMUST00000253551.1 ENSMUSG00000122539 (from geneSymbol) uc331wmt.1 uc331wmt.1 
ENSMUST00000253552.1 ENSMUSG00000122540 ENSMUST00000253552.1 ENSMUSG00000122540 (from geneSymbol) uc331wmu.1 uc331wmu.1 
ENSMUST00000253554.1 ENSMUSG00000122541 ENSMUST00000253554.1 ENSMUSG00000122541 (from geneSymbol) uc331wmw.1 uc331wmw.1 
ENSMUST00000253585.1 ENSMUSG00000122542 ENSMUST00000253585.1 ENSMUSG00000122542 (from geneSymbol) BC049966 uc331woa.1 uc331woa.1 
ENSMUST00000253589.1 ENSMUSG00000122543 ENSMUST00000253589.1 ENSMUSG00000122543 (from geneSymbol) uc331woe.1 uc331woe.1 
ENSMUST00000253598.1 ENSMUSG00000122544 ENSMUST00000253598.1 ENSMUSG00000122544 (from geneSymbol) LF201506 uc331won.1 uc331won.1 
ENSMUST00000253599.1 ENSMUSG00000122545 ENSMUST00000253599.1 ENSMUSG00000122545 (from geneSymbol) uc331woo.1 uc331woo.1 
ENSMUST00000253600.1 ENSMUSG00000122546 ENSMUST00000253600.1 ENSMUSG00000122546 (from geneSymbol) uc331wop.1 uc331wop.1 
ENSMUST00000253601.1 ENSMUSG00000122547 ENSMUST00000253601.1 ENSMUSG00000122547 (from geneSymbol) uc331woq.1 uc331woq.1 
ENSMUST00000253602.1 ENSMUSG00000122548 ENSMUST00000253602.1 ENSMUSG00000122548 (from geneSymbol) uc331wor.1 uc331wor.1 
ENSMUST00000253603.1 Gm49643 ENSMUST00000253603.1 Gm49643 (from geneSymbol) AK015140 uc331wos.1 uc331wos.1 
ENSMUST00000253604.1 ENSMUSG00000122549 ENSMUST00000253604.1 ENSMUSG00000122549 (from geneSymbol) uc331wot.1 uc331wot.1 
ENSMUST00000253605.1 ENSMUSG00000122550 ENSMUST00000253605.1 ENSMUSG00000122550 (from geneSymbol) uc331wou.1 uc331wou.1 
ENSMUST00000253606.1 Gm57027 ENSMUST00000253606.1 Gm57027 (from geneSymbol) uc331wov.1 uc331wov.1 
ENSMUST00000253608.1 ENSMUSG00000122551 ENSMUST00000253608.1 ENSMUSG00000122551 (from geneSymbol) uc331wox.1 uc331wox.1 
ENSMUST00000253609.1 ENSMUSG00000122552 ENSMUST00000253609.1 ENSMUSG00000122552 (from geneSymbol) uc331woy.1 uc331woy.1 
ENSMUST00000253629.1 ENSMUSG00000122553 ENSMUST00000253629.1 ENSMUSG00000122553 (from geneSymbol) uc331wps.1 uc331wps.1 
ENSMUST00000253630.1 ENSMUSG00000122554 ENSMUST00000253630.1 ENSMUSG00000122554 (from geneSymbol) uc331wpt.1 uc331wpt.1 
ENSMUST00000253631.1 ENSMUSG00000122555 ENSMUST00000253631.1 ENSMUSG00000122555 (from geneSymbol) uc331wpu.1 uc331wpu.1 
ENSMUST00000253632.1 ENSMUSG00000122556 ENSMUST00000253632.1 ENSMUSG00000122556 (from geneSymbol) uc331wpv.1 uc331wpv.1 
ENSMUST00000253637.1 ENSMUSG00000122557 ENSMUST00000253637.1 ENSMUSG00000122557 (from geneSymbol) uc331wqa.1 uc331wqa.1 
ENSMUST00000253638.1 ENSMUSG00000122558 ENSMUST00000253638.1 ENSMUSG00000122558 (from geneSymbol) AK018213 uc331wqb.1 uc331wqb.1 
ENSMUST00000253639.1 ENSMUSG00000122559 ENSMUST00000253639.1 ENSMUSG00000122559 (from geneSymbol) AK006572 uc331wqc.1 uc331wqc.1 
ENSMUST00000253645.1 Gm34655 ENSMUST00000253645.1 Gm34655 (from geneSymbol) uc331wqi.1 uc331wqi.1 
ENSMUST00000253667.1 ENSMUSG00000122560 ENSMUST00000253667.1 ENSMUSG00000122560 (from geneSymbol) uc331wre.1 uc331wre.1 
ENSMUST00000253669.1 ENSMUSG00000122561 ENSMUST00000253669.1 ENSMUSG00000122561 (from geneSymbol) uc331wrg.1 uc331wrg.1 
ENSMUST00000253671.1 ENSMUSG00000122562 ENSMUST00000253671.1 ENSMUSG00000122562 (from geneSymbol) uc331wri.1 uc331wri.1 
ENSMUST00000253672.1 ENSMUSG00000122563 ENSMUST00000253672.1 ENSMUSG00000122563 (from geneSymbol) uc331wrj.1 uc331wrj.1 
ENSMUST00000253673.1 ENSMUSG00000122564 ENSMUST00000253673.1 ENSMUSG00000122564 (from geneSymbol) uc331wrk.1 uc331wrk.1 
ENSMUST00000253674.1 ENSMUSG00000122565 ENSMUST00000253674.1 ENSMUSG00000122565 (from geneSymbol) AY040842 uc331wrl.1 uc331wrl.1 
ENSMUST00000253676.1 ENSMUSG00000122566 ENSMUST00000253676.1 ENSMUSG00000122566 (from geneSymbol) uc331wrn.1 uc331wrn.1 
ENSMUST00000253680.1 ENSMUSG00000122567 ENSMUST00000253680.1 ENSMUSG00000122567 (from geneSymbol) uc331wrr.1 uc331wrr.1 
ENSMUST00000253682.1 ENSMUSG00000122568 ENSMUST00000253682.1 ENSMUSG00000122568 (from geneSymbol) AK144860 uc331wrt.1 uc331wrt.1 
ENSMUST00000253688.1 ENSMUSG00000122569 ENSMUST00000253688.1 ENSMUSG00000122569 (from geneSymbol) uc331wrz.1 uc331wrz.1 
ENSMUST00000253691.1 ENSMUSG00000122570 ENSMUST00000253691.1 ENSMUSG00000122570 (from geneSymbol) uc331wsc.1 uc331wsc.1 
ENSMUST00000253692.1 ENSMUSG00000122571 ENSMUST00000253692.1 ENSMUSG00000122571 (from geneSymbol) uc331wsd.1 uc331wsd.1 
ENSMUST00000253693.1 ENSMUSG00000122572 ENSMUST00000253693.1 ENSMUSG00000122572 (from geneSymbol) uc331wse.1 uc331wse.1 
ENSMUST00000253694.1 Gm40438 ENSMUST00000253694.1 Gm40438 (from geneSymbol) AK050197 uc331wsf.1 uc331wsf.1 
ENSMUST00000253751.1 ENSMUSG00000122573 ENSMUST00000253751.1 ENSMUSG00000122573 (from geneSymbol) uc331wuk.1 uc331wuk.1 
ENSMUST00000253773.1 Gm33440 ENSMUST00000253773.1 Gm33440 (from geneSymbol) uc331wvg.1 uc331wvg.1 
ENSMUST00000253806.1 ENSMUSG00000122574 ENSMUST00000253806.1 ENSMUSG00000122574 (from geneSymbol) uc331wwn.1 uc331wwn.1 
ENSMUST00000253807.1 ENSMUSG00000122575 ENSMUST00000253807.1 ENSMUSG00000122575 (from geneSymbol) uc331wwo.1 uc331wwo.1 
ENSMUST00000253810.1 Gm14244 ENSMUST00000253810.1 Gm14244 (from geneSymbol) AK029760 uc331wwq.1 uc331wwq.1 
ENSMUST00000253815.1 ENSMUSG00000122576 ENSMUST00000253815.1 ENSMUSG00000122576 (from geneSymbol) uc331wwv.1 uc331wwv.1 
ENSMUST00000253818.1 ENSMUSG00000122577 ENSMUST00000253818.1 ENSMUSG00000122577 (from geneSymbol) uc331wwy.1 uc331wwy.1 
ENSMUST00000253822.1 ENSMUSG00000122578 ENSMUST00000253822.1 ENSMUSG00000122578 (from geneSymbol) uc331wxc.1 uc331wxc.1 
ENSMUST00000253823.1 ENSMUSG00000122579 ENSMUST00000253823.1 ENSMUSG00000122579 (from geneSymbol) uc331wxd.1 uc331wxd.1 
ENSMUST00000253824.1 Gm8817 ENSMUST00000253824.1 Gm8817 (from geneSymbol) AK041611 uc331wxe.1 uc331wxe.1 
ENSMUST00000253859.1 ENSMUSG00000122580 ENSMUST00000253859.1 ENSMUSG00000122580 (from geneSymbol) uc331wyn.1 uc331wyn.1 
ENSMUST00000253860.1 4930447A16Rik ENSMUST00000253860.1 4930447A16Rik (from geneSymbol) AK015396 uc331wyo.1 uc331wyo.1 
ENSMUST00000253862.1 ENSMUSG00000122581 ENSMUST00000253862.1 ENSMUSG00000122581 (from geneSymbol) uc331wyq.1 uc331wyq.1 
ENSMUST00000253863.1 ENSMUSG00000122582 ENSMUST00000253863.1 ENSMUSG00000122582 (from geneSymbol) uc331wyr.1 uc331wyr.1 
ENSMUST00000253865.1 ENSMUSG00000122583 ENSMUST00000253865.1 ENSMUSG00000122583 (from geneSymbol) AK144961 uc331wyt.1 uc331wyt.1 
ENSMUST00000253870.1 ENSMUSG00000122584 ENSMUST00000253870.1 ENSMUSG00000122584 (from geneSymbol) uc331wyy.1 uc331wyy.1 
ENSMUST00000253879.1 ENSMUSG00000122585 ENSMUST00000253879.1 ENSMUSG00000122585 (from geneSymbol) uc331wzh.1 uc331wzh.1 
ENSMUST00000253880.1 Gm44009 ENSMUST00000253880.1 Gm44009 (from geneSymbol) uc331wzi.1 uc331wzi.1 
ENSMUST00000253882.1 ENSMUSG00000122586 ENSMUST00000253882.1 ENSMUSG00000122586 (from geneSymbol) uc331wzk.1 uc331wzk.1 
ENSMUST00000253884.1 ENSMUSG00000122587 ENSMUST00000253884.1 ENSMUSG00000122587 (from geneSymbol) uc331wzm.1 uc331wzm.1 
ENSMUST00000253885.1 ENSMUSG00000122588 ENSMUST00000253885.1 ENSMUSG00000122588 (from geneSymbol) uc331wzn.1 uc331wzn.1 
ENSMUST00000253888.1 Gm12688 ENSMUST00000253888.1 Gm12688 (from geneSymbol) uc331wzq.1 uc331wzq.1 
ENSMUST00000253897.1 ENSMUSG00000122589 ENSMUST00000253897.1 ENSMUSG00000122589 (from geneSymbol) uc331wzz.1 uc331wzz.1 
ENSMUST00000253924.1 ENSMUSG00000122590 ENSMUST00000253924.1 ENSMUSG00000122590 (from geneSymbol) uc331xba.1 uc331xba.1 
ENSMUST00000253925.1 ENSMUSG00000122591 ENSMUST00000253925.1 ENSMUSG00000122591 (from geneSymbol) uc331xbb.1 uc331xbb.1 
ENSMUST00000253929.1 ENSMUSG00000122592 ENSMUST00000253929.1 ENSMUSG00000122592 (from geneSymbol) uc331xbf.1 uc331xbf.1 
ENSMUST00000253930.1 ENSMUSG00000122593 ENSMUST00000253930.1 ENSMUSG00000122593 (from geneSymbol) uc331xbg.1 uc331xbg.1 
ENSMUST00000253931.1 ENSMUSG00000122594 ENSMUST00000253931.1 ENSMUSG00000122594 (from geneSymbol) uc331xbh.1 uc331xbh.1 
ENSMUST00000253932.1 ENSMUSG00000122595 ENSMUST00000253932.1 ENSMUSG00000122595 (from geneSymbol) uc331xbi.1 uc331xbi.1 
ENSMUST00000253934.1 ENSMUSG00000122596 ENSMUST00000253934.1 ENSMUSG00000122596 (from geneSymbol) uc331xbk.1 uc331xbk.1 
ENSMUST00000253935.1 ENSMUSG00000122597 ENSMUST00000253935.1 ENSMUSG00000122597 (from geneSymbol) uc331xbl.1 uc331xbl.1 
ENSMUST00000253936.1 ENSMUSG00000122598 ENSMUST00000253936.1 ENSMUSG00000122598 (from geneSymbol) uc331xbm.1 uc331xbm.1 
ENSMUST00000253937.1 Gm49893 ENSMUST00000253937.1 Gm49893 (from geneSymbol) uc331xbn.1 uc331xbn.1 
ENSMUST00000253939.1 ENSMUSG00000122599 ENSMUST00000253939.1 ENSMUSG00000122599 (from geneSymbol) uc331xbp.1 uc331xbp.1 
ENSMUST00000253957.1 ENSMUSG00000122601 ENSMUST00000253957.1 ENSMUSG00000122601 (from geneSymbol) uc331xcg.1 uc331xcg.1 
ENSMUST00000253958.1 ENSMUSG00000122602 ENSMUST00000253958.1 ENSMUSG00000122602 (from geneSymbol) uc331xch.1 uc331xch.1 
ENSMUST00000253961.1 ENSMUSG00000122603 ENSMUST00000253961.1 ENSMUSG00000122603 (from geneSymbol) uc331xck.1 uc331xck.1 
ENSMUST00000253963.1 ENSMUSG00000122604 ENSMUST00000253963.1 ENSMUSG00000122604 (from geneSymbol) uc331xcm.1 uc331xcm.1 
ENSMUST00000253970.1 ENSMUSG00000122605 ENSMUST00000253970.1 ENSMUSG00000122605 (from geneSymbol) uc331xct.1 uc331xct.1 
ENSMUST00000253971.1 ENSMUSG00000122606 ENSMUST00000253971.1 ENSMUSG00000122606 (from geneSymbol) uc331xcu.1 uc331xcu.1 
ENSMUST00000253972.1 ENSMUSG00000122607 ENSMUST00000253972.1 ENSMUSG00000122607 (from geneSymbol) uc331xcv.1 uc331xcv.1 
ENSMUST00000253974.1 ENSMUSG00000122608 ENSMUST00000253974.1 ENSMUSG00000122608 (from geneSymbol) uc331xcx.1 uc331xcx.1 
ENSMUST00000253976.1 ENSMUSG00000122609 ENSMUST00000253976.1 ENSMUSG00000122609 (from geneSymbol) uc331xcz.1 uc331xcz.1 
ENSMUST00000253978.1 ENSMUSG00000122610 ENSMUST00000253978.1 ENSMUSG00000122610 (from geneSymbol) uc331xdb.1 uc331xdb.1 
ENSMUST00000253979.1 ENSMUSG00000122611 ENSMUST00000253979.1 ENSMUSG00000122611 (from geneSymbol) uc331xdc.1 uc331xdc.1 
ENSMUST00000253981.1 ENSMUSG00000122612 ENSMUST00000253981.1 ENSMUSG00000122612 (from geneSymbol) uc331xde.1 uc331xde.1 
ENSMUST00000253986.1 ENSMUSG00000122613 ENSMUST00000253986.1 ENSMUSG00000122613 (from geneSymbol) AK015261 uc331xdj.1 uc331xdj.1 
ENSMUST00000253989.1 Gm16175 ENSMUST00000253989.1 Gm16175 (from geneSymbol) uc331xdm.1 uc331xdm.1 
ENSMUST00000253995.1 ENSMUSG00000122614 ENSMUST00000253995.1 ENSMUSG00000122614 (from geneSymbol) uc331xds.1 uc331xds.1 
ENSMUST00000253996.1 ENSMUSG00000122615 ENSMUST00000253996.1 ENSMUSG00000122615 (from geneSymbol) uc331xdt.1 uc331xdt.1 
ENSMUST00000253999.1 Gm48395 ENSMUST00000253999.1 Gm48395 (from geneSymbol) uc331xdw.1 uc331xdw.1 
ENSMUST00000254008.1 ENSMUSG00000122616 ENSMUST00000254008.1 ENSMUSG00000122616 (from geneSymbol) AK138383 uc331xef.1 uc331xef.1 
ENSMUST00000254012.1 ENSMUSG00000122617 ENSMUST00000254012.1 ENSMUSG00000122617 (from geneSymbol) uc331xej.1 uc331xej.1 
ENSMUST00000254014.1 4932413F04Rik ENSMUST00000254014.1 4932413F04Rik (from geneSymbol) AK077024 uc331xel.1 uc331xel.1 
ENSMUST00000254017.1 ENSMUSG00000122618 ENSMUST00000254017.1 ENSMUSG00000122618 (from geneSymbol) uc331xeo.1 uc331xeo.1 
ENSMUST00000254023.1 ENSMUSG00000122619 ENSMUST00000254023.1 ENSMUSG00000122619 (from geneSymbol) uc331xeu.1 uc331xeu.1 
ENSMUST00000254024.1 ENSMUSG00000122620 ENSMUST00000254024.1 ENSMUSG00000122620 (from geneSymbol) uc331xev.1 uc331xev.1 
ENSMUST00000254025.1 ENSMUSG00000122621 ENSMUST00000254025.1 ENSMUSG00000122621 (from geneSymbol) uc331xew.1 uc331xew.1 
ENSMUST00000254026.1 ENSMUSG00000122622 ENSMUST00000254026.1 ENSMUSG00000122622 (from geneSymbol) uc331xex.1 uc331xex.1 
ENSMUST00000254028.1 ENSMUSG00000122623 ENSMUST00000254028.1 ENSMUSG00000122623 (from geneSymbol) uc331xez.1 uc331xez.1 
ENSMUST00000254029.1 ENSMUSG00000122624 ENSMUST00000254029.1 ENSMUSG00000122624 (from geneSymbol) uc331xfa.1 uc331xfa.1 
ENSMUST00000254035.1 ENSMUSG00000122625 ENSMUST00000254035.1 ENSMUSG00000122625 (from geneSymbol) uc331xfg.1 uc331xfg.1 
ENSMUST00000254039.1 ENSMUSG00000122626 ENSMUST00000254039.1 ENSMUSG00000122626 (from geneSymbol) uc331xfk.1 uc331xfk.1 
ENSMUST00000254042.1 ENSMUSG00000122627 ENSMUST00000254042.1 ENSMUSG00000122627 (from geneSymbol) uc331xfn.1 uc331xfn.1 
ENSMUST00000254043.1 ENSMUSG00000122628 ENSMUST00000254043.1 ENSMUSG00000122628 (from geneSymbol) uc331xfo.1 uc331xfo.1 
ENSMUST00000254044.1 ENSMUSG00000122629 ENSMUST00000254044.1 ENSMUSG00000122629 (from geneSymbol) BC048762 uc331xfp.1 uc331xfp.1 
ENSMUST00000254047.1 Gm57124 ENSMUST00000254047.1 Gm57124 (from geneSymbol) uc331xfs.1 uc331xfs.1 
ENSMUST00000254054.1 ENSMUSG00000122630 ENSMUST00000254054.1 ENSMUSG00000122630 (from geneSymbol) uc331xfz.1 uc331xfz.1 
ENSMUST00000254057.1 ENSMUSG00000122631 ENSMUST00000254057.1 ENSMUSG00000122631 (from geneSymbol) uc331xgc.1 uc331xgc.1 
ENSMUST00000254061.1 ENSMUSG00000122632 ENSMUST00000254061.1 ENSMUSG00000122632 (from geneSymbol) uc331xgg.1 uc331xgg.1 
ENSMUST00000254062.1 ENSMUSG00000122633 ENSMUST00000254062.1 ENSMUSG00000122633 (from geneSymbol) uc331xgh.1 uc331xgh.1 
ENSMUST00000254063.1 ENSMUSG00000122634 ENSMUST00000254063.1 ENSMUSG00000122634 (from geneSymbol) uc331xgi.1 uc331xgi.1 
ENSMUST00000254067.1 ENSMUSG00000122635 ENSMUST00000254067.1 ENSMUSG00000122635 (from geneSymbol) uc331xgm.1 uc331xgm.1 
ENSMUST00000254068.1 ENSMUSG00000122636 ENSMUST00000254068.1 ENSMUSG00000122636 (from geneSymbol) uc331xgn.1 uc331xgn.1 
ENSMUST00000254069.1 ENSMUSG00000122637 ENSMUST00000254069.1 ENSMUSG00000122637 (from geneSymbol) uc331xgo.1 uc331xgo.1 
ENSMUST00000254093.1 ENSMUSG00000122638 ENSMUST00000254093.1 ENSMUSG00000122638 (from geneSymbol) uc331xhm.1 uc331xhm.1 
ENSMUST00000254094.1 ENSMUSG00000122639 ENSMUST00000254094.1 ENSMUSG00000122639 (from geneSymbol) uc331xhn.1 uc331xhn.1 
ENSMUST00000254095.1 ENSMUSG00000122640 ENSMUST00000254095.1 ENSMUSG00000122640 (from geneSymbol) uc331xho.1 uc331xho.1 
ENSMUST00000254099.1 ENSMUSG00000122641 ENSMUST00000254099.1 ENSMUSG00000122641 (from geneSymbol) uc331xhs.1 uc331xhs.1 
ENSMUST00000254100.1 ENSMUSG00000122642 ENSMUST00000254100.1 ENSMUSG00000122642 (from geneSymbol) uc331xht.1 uc331xht.1 
ENSMUST00000254103.1 ENSMUSG00000122644 ENSMUST00000254103.1 ENSMUSG00000122644 (from geneSymbol) uc331xhv.1 uc331xhv.1 
ENSMUST00000254104.1 ENSMUSG00000122645 ENSMUST00000254104.1 ENSMUSG00000122645 (from geneSymbol) uc331xhw.1 uc331xhw.1 
ENSMUST00000254105.1 ENSMUSG00000122646 ENSMUST00000254105.1 ENSMUSG00000122646 (from geneSymbol) uc331xhx.1 uc331xhx.1 
ENSMUST00000254106.1 ENSMUSG00000122647 ENSMUST00000254106.1 ENSMUSG00000122647 (from geneSymbol) uc331xhy.1 uc331xhy.1 
ENSMUST00000254109.1 ENSMUSG00000122648 ENSMUST00000254109.1 ENSMUSG00000122648 (from geneSymbol) uc331xib.1 uc331xib.1 
ENSMUST00000254145.1 ENSMUSG00000122649 ENSMUST00000254145.1 ENSMUSG00000122649 (from geneSymbol) uc331xjl.1 uc331xjl.1 
ENSMUST00000254148.1 ENSMUSG00000122650 ENSMUST00000254148.1 ENSMUSG00000122650 (from geneSymbol) uc331xjo.1 uc331xjo.1 
ENSMUST00000254149.1 ENSMUSG00000122651 ENSMUST00000254149.1 ENSMUSG00000122651 (from geneSymbol) uc331xjp.1 uc331xjp.1 
ENSMUST00000254151.1 ENSMUSG00000122652 ENSMUST00000254151.1 ENSMUSG00000122652 (from geneSymbol) uc331xjr.1 uc331xjr.1 
ENSMUST00000254154.1 ENSMUSG00000122653 ENSMUST00000254154.1 ENSMUSG00000122653 (from geneSymbol) uc331xju.1 uc331xju.1 
ENSMUST00000254155.1 ENSMUSG00000122654 ENSMUST00000254155.1 ENSMUSG00000122654 (from geneSymbol) uc331xjv.1 uc331xjv.1 
ENSMUST00000254157.1 ENSMUSG00000122655 ENSMUST00000254157.1 ENSMUSG00000122655 (from geneSymbol) uc331xjx.1 uc331xjx.1 
ENSMUST00000254158.1 ENSMUSG00000122656 ENSMUST00000254158.1 ENSMUSG00000122656 (from geneSymbol) uc331xjy.1 uc331xjy.1 
ENSMUST00000254182.1 4930526H09Rik ENSMUST00000254182.1 4930526H09Rik (from geneSymbol) AK015902 uc331xkv.1 uc331xkv.1 
ENSMUST00000254184.1 ENSMUSG00000122659 ENSMUST00000254184.1 ENSMUSG00000122659 (from geneSymbol) uc331xkw.1 uc331xkw.1 
ENSMUST00000254187.1 ENSMUSG00000122660 ENSMUST00000254187.1 ENSMUSG00000122660 (from geneSymbol) uc331xkz.1 uc331xkz.1 
ENSMUST00000254192.1 ENSMUSG00000122661 ENSMUST00000254192.1 ENSMUSG00000122661 (from geneSymbol) uc331xle.1 uc331xle.1 
ENSMUST00000254198.1 ENSMUSG00000122662 ENSMUST00000254198.1 ENSMUSG00000122662 (from geneSymbol) uc331xlk.1 uc331xlk.1 
ENSMUST00000254200.1 ENSMUSG00000122663 ENSMUST00000254200.1 ENSMUSG00000122663 (from geneSymbol) uc331xlm.1 uc331xlm.1 
ENSMUST00000254201.1 ENSMUSG00000122664 ENSMUST00000254201.1 ENSMUSG00000122664 (from geneSymbol) uc331xln.1 uc331xln.1 
ENSMUST00000254202.1 ENSMUSG00000122665 ENSMUST00000254202.1 ENSMUSG00000122665 (from geneSymbol) AK131781 uc331xlo.1 uc331xlo.1 
ENSMUST00000254203.1 ENSMUSG00000122666 ENSMUST00000254203.1 ENSMUSG00000122666 (from geneSymbol) uc331xlp.1 uc331xlp.1 
ENSMUST00000254204.1 ENSMUSG00000122667 ENSMUST00000254204.1 ENSMUSG00000122667 (from geneSymbol) uc331xlq.1 uc331xlq.1 
ENSMUST00000254205.1 ENSMUSG00000122668 ENSMUST00000254205.1 ENSMUSG00000122668 (from geneSymbol) uc331xlr.1 uc331xlr.1 
ENSMUST00000254206.1 ENSMUSG00000122669 ENSMUST00000254206.1 ENSMUSG00000122669 (from geneSymbol) uc331xls.1 uc331xls.1 
ENSMUST00000254207.1 ENSMUSG00000122670 ENSMUST00000254207.1 ENSMUSG00000122670 (from geneSymbol) uc331xlt.1 uc331xlt.1 
ENSMUST00000254214.1 ENSMUSG00000122671 ENSMUST00000254214.1 ENSMUSG00000122671 (from geneSymbol) uc331xma.1 uc331xma.1 
ENSMUST00000254217.1 ENSMUSG00000122672 ENSMUST00000254217.1 ENSMUSG00000122672 (from geneSymbol) uc331xmd.1 uc331xmd.1 
ENSMUST00000254220.1 ENSMUSG00000122673 ENSMUST00000254220.1 ENSMUSG00000122673 (from geneSymbol) uc331xmg.1 uc331xmg.1 
ENSMUST00000254222.1 ENSMUSG00000122674 ENSMUST00000254222.1 ENSMUSG00000122674 (from geneSymbol) uc331xmi.1 uc331xmi.1 
ENSMUST00000254228.1 ENSMUSG00000122675 ENSMUST00000254228.1 ENSMUSG00000122675 (from geneSymbol) uc331xmo.1 uc331xmo.1 
ENSMUST00000254231.1 ENSMUSG00000122676 ENSMUST00000254231.1 ENSMUSG00000122676 (from geneSymbol) uc331xmr.1 uc331xmr.1 
ENSMUST00000254232.1 ENSMUSG00000122677 ENSMUST00000254232.1 ENSMUSG00000122677 (from geneSymbol) uc331xms.1 uc331xms.1 
ENSMUST00000254233.1 ENSMUSG00000122678 ENSMUST00000254233.1 ENSMUSG00000122678 (from geneSymbol) uc331xmt.1 uc331xmt.1 
ENSMUST00000254234.1 ENSMUSG00000122679 ENSMUST00000254234.1 ENSMUSG00000122679 (from geneSymbol) uc331xmu.1 uc331xmu.1 
ENSMUST00000254236.1 ENSMUSG00000122680 ENSMUST00000254236.1 ENSMUSG00000122680 (from geneSymbol) uc331xmw.1 uc331xmw.1 
ENSMUST00000254238.1 ENSMUSG00000122681 ENSMUST00000254238.1 ENSMUSG00000122681 (from geneSymbol) uc331xmy.1 uc331xmy.1 
ENSMUST00000254243.1 ENSMUSG00000122682 ENSMUST00000254243.1 ENSMUSG00000122682 (from geneSymbol) uc331xnd.1 uc331xnd.1 
ENSMUST00000254247.1 Gm35514 ENSMUST00000254247.1 Gm35514 (from geneSymbol) uc331xnh.1 uc331xnh.1 
ENSMUST00000254252.1 ENSMUSG00000122683 ENSMUST00000254252.1 ENSMUSG00000122683 (from geneSymbol) uc331xnm.1 uc331xnm.1 
ENSMUST00000254253.1 ENSMUSG00000122684 ENSMUST00000254253.1 ENSMUSG00000122684 (from geneSymbol) uc331xnn.1 uc331xnn.1 
ENSMUST00000254254.1 ENSMUSG00000122685 ENSMUST00000254254.1 ENSMUSG00000122685 (from geneSymbol) uc331xno.1 uc331xno.1 
ENSMUST00000254262.1 ENSMUSG00000122686 ENSMUST00000254262.1 ENSMUSG00000122686 (from geneSymbol) uc331xnw.1 uc331xnw.1 
ENSMUST00000254264.1 ENSMUSG00000122687 ENSMUST00000254264.1 ENSMUSG00000122687 (from geneSymbol) uc331xny.1 uc331xny.1 
ENSMUST00000254272.1 ENSMUSG00000122690 ENSMUST00000254272.1 ENSMUSG00000122690 (from geneSymbol) uc331xod.1 uc331xod.1 
ENSMUST00000254274.1 ENSMUSG00000122691 ENSMUST00000254274.1 ENSMUSG00000122691 (from geneSymbol) uc331xof.1 uc331xof.1 
ENSMUST00000254297.1 9430085M18Rik ENSMUST00000254297.1 9430085M18Rik (from geneSymbol) AK020506 uc331xpc.1 uc331xpc.1 
ENSMUST00000254302.1 ENSMUSG00000122692 ENSMUST00000254302.1 ENSMUSG00000122692 (from geneSymbol) uc331xph.1 uc331xph.1 
ENSMUST00000254305.1 Gm9873 ENSMUST00000254305.1 Gm9873 (from geneSymbol) uc331xpk.1 uc331xpk.1 
ENSMUST00000254313.1 ENSMUSG00000122693 ENSMUST00000254313.1 ENSMUSG00000122693 (from geneSymbol) uc331xps.1 uc331xps.1 
ENSMUST00000254315.1 ENSMUSG00000122694 ENSMUST00000254315.1 ENSMUSG00000122694 (from geneSymbol) uc331xpu.1 uc331xpu.1 
ENSMUST00000254319.1 ENSMUSG00000122695 ENSMUST00000254319.1 ENSMUSG00000122695 (from geneSymbol) uc331xpy.1 uc331xpy.1 
ENSMUST00000254329.1 ENSMUSG00000122696 ENSMUST00000254329.1 ENSMUSG00000122696 (from geneSymbol) uc331xqh.1 uc331xqh.1 
ENSMUST00000254330.1 ENSMUSG00000122697 ENSMUST00000254330.1 ENSMUSG00000122697 (from geneSymbol) uc331xqi.1 uc331xqi.1 
ENSMUST00000254331.1 ENSMUSG00000122698 ENSMUST00000254331.1 ENSMUSG00000122698 (from geneSymbol) uc331xqj.1 uc331xqj.1 
ENSMUST00000254333.1 ENSMUSG00000122699 ENSMUST00000254333.1 ENSMUSG00000122699 (from geneSymbol) uc331xql.1 uc331xql.1 
ENSMUST00000254342.1 5033403H07Rik ENSMUST00000254342.1 5033403H07Rik (from geneSymbol) AK017148 uc331xqu.1 uc331xqu.1 
ENSMUST00000254385.1 Gm45505 ENSMUST00000254385.1 Gm45505 (from geneSymbol) uc331xsl.1 uc331xsl.1 
ENSMUST00000254389.1 ENSMUSG00000122700 ENSMUST00000254389.1 ENSMUSG00000122700 (from geneSymbol) uc331xsp.1 uc331xsp.1 
ENSMUST00000254391.1 ENSMUSG00000122701 ENSMUST00000254391.1 ENSMUSG00000122701 (from geneSymbol) uc331xsr.1 uc331xsr.1 
ENSMUST00000254393.1 ENSMUSG00000122702 ENSMUST00000254393.1 ENSMUSG00000122702 (from geneSymbol) uc331xst.1 uc331xst.1 
ENSMUST00000254394.1 ENSMUSG00000122703 ENSMUST00000254394.1 ENSMUSG00000122703 (from geneSymbol) uc331xsu.1 uc331xsu.1 
ENSMUST00000254397.1 ENSMUSG00000122704 ENSMUST00000254397.1 ENSMUSG00000122704 (from geneSymbol) uc331xsx.1 uc331xsx.1 
ENSMUST00000254403.1 4930540M03Rik ENSMUST00000254403.1 4930540M03Rik (from geneSymbol) AK019729 uc331xtd.1 uc331xtd.1 
ENSMUST00000254440.1 ENSMUSG00000122705 ENSMUST00000254440.1 ENSMUSG00000122705 (from geneSymbol) uc331xuo.1 uc331xuo.1 
ENSMUST00000254442.1 ENSMUSG00000122706 ENSMUST00000254442.1 ENSMUSG00000122706 (from geneSymbol) AK156673 uc331xuq.1 uc331xuq.1 
ENSMUST00000254447.1 ENSMUSG00000122708 ENSMUST00000254447.1 ENSMUSG00000122708 (from geneSymbol) uc331xut.1 uc331xut.1 
ENSMUST00000254449.1 ENSMUSG00000122709 ENSMUST00000254449.1 ENSMUSG00000122709 (from geneSymbol) uc331xuv.1 uc331xuv.1 
ENSMUST00000254450.1 ENSMUSG00000122710 ENSMUST00000254450.1 ENSMUSG00000122710 (from geneSymbol) uc331xuw.1 uc331xuw.1 
ENSMUST00000254453.1 ENSMUSG00000122711 ENSMUST00000254453.1 ENSMUSG00000122711 (from geneSymbol) uc331xuz.1 uc331xuz.1 
ENSMUST00000254454.1 ENSMUSG00000122712 ENSMUST00000254454.1 ENSMUSG00000122712 (from geneSymbol) uc331xva.1 uc331xva.1 
ENSMUST00000254456.1 ENSMUSG00000122713 ENSMUST00000254456.1 ENSMUSG00000122713 (from geneSymbol) uc331xvc.1 uc331xvc.1 
ENSMUST00000254458.1 ENSMUSG00000122714 ENSMUST00000254458.1 ENSMUSG00000122714 (from geneSymbol) AK133600 uc331xve.1 uc331xve.1 
ENSMUST00000254459.1 ENSMUSG00000122715 ENSMUST00000254459.1 ENSMUSG00000122715 (from geneSymbol) uc331xvf.1 uc331xvf.1 
ENSMUST00000254460.1 ENSMUSG00000122716 ENSMUST00000254460.1 ENSMUSG00000122716 (from geneSymbol) uc331xvg.1 uc331xvg.1 
ENSMUST00000254461.1 ENSMUSG00000122717 ENSMUST00000254461.1 ENSMUSG00000122717 (from geneSymbol) uc331xvh.1 uc331xvh.1 
ENSMUST00000254463.1 ENSMUSG00000122718 ENSMUST00000254463.1 ENSMUSG00000122718 (from geneSymbol) uc331xvj.1 uc331xvj.1 
ENSMUST00000254464.1 ENSMUSG00000122719 ENSMUST00000254464.1 ENSMUSG00000122719 (from geneSymbol) uc331xvk.1 uc331xvk.1 
ENSMUST00000254466.1 ENSMUSG00000122720 ENSMUST00000254466.1 ENSMUSG00000122720 (from geneSymbol) KY467692 uc331xvm.1 uc331xvm.1 
ENSMUST00000254469.1 ENSMUSG00000122721 ENSMUST00000254469.1 ENSMUSG00000122721 (from geneSymbol) uc331xvp.1 uc331xvp.1 
ENSMUST00000254470.1 ENSMUSG00000122722 ENSMUST00000254470.1 ENSMUSG00000122722 (from geneSymbol) uc331xvq.1 uc331xvq.1 
ENSMUST00000254471.1 Gm14858 ENSMUST00000254471.1 Gm14858 (from geneSymbol) AK090266 uc331xvr.1 uc331xvr.1 
ENSMUST00000254472.1 ENSMUSG00000122723 ENSMUST00000254472.1 ENSMUSG00000122723 (from geneSymbol) uc331xvs.1 uc331xvs.1 
ENSMUST00000254477.1 Gm43666 ENSMUST00000254477.1 Gm43666 (from geneSymbol) uc331xvx.1 uc331xvx.1 
ENSMUST00000254480.1 ENSMUSG00000122724 ENSMUST00000254480.1 ENSMUSG00000122724 (from geneSymbol) uc331xwa.1 uc331xwa.1 
ENSMUST00000254492.1 ENSMUSG00000122726 ENSMUST00000254492.1 ENSMUSG00000122726 (from geneSymbol) uc331xwk.1 uc331xwk.1 
ENSMUST00000254493.1 ENSMUSG00000122727 ENSMUST00000254493.1 ENSMUSG00000122727 (from geneSymbol) uc331xwl.1 uc331xwl.1 
ENSMUST00000254494.1 ENSMUSG00000122728 ENSMUST00000254494.1 ENSMUSG00000122728 (from geneSymbol) uc331xwm.1 uc331xwm.1 
ENSMUST00000254496.1 ENSMUSG00000122729 ENSMUST00000254496.1 ENSMUSG00000122729 (from geneSymbol) uc331xwo.1 uc331xwo.1 
ENSMUST00000254497.1 Gm45442 ENSMUST00000254497.1 Gm45442 (from geneSymbol) uc331xwp.1 uc331xwp.1 
ENSMUST00000254505.1 ENSMUSG00000122730 ENSMUST00000254505.1 ENSMUSG00000122730 (from geneSymbol) uc331xwx.1 uc331xwx.1 
ENSMUST00000254506.1 Gm44764 ENSMUST00000254506.1 Gm44764 (from geneSymbol) uc331xwy.1 uc331xwy.1 
ENSMUST00000254511.1 Gm42133 ENSMUST00000254511.1 Gm42133 (from geneSymbol) uc331xxd.1 uc331xxd.1 
ENSMUST00000254515.1 ENSMUSG00000122731 ENSMUST00000254515.1 ENSMUSG00000122731 (from geneSymbol) uc331xxh.1 uc331xxh.1 
ENSMUST00000254520.1 ENSMUSG00000122732 ENSMUST00000254520.1 ENSMUSG00000122732 (from geneSymbol) uc331xxm.1 uc331xxm.1 
ENSMUST00000254534.1 ENSMUSG00000122733 ENSMUST00000254534.1 ENSMUSG00000122733 (from geneSymbol) uc331xya.1 uc331xya.1 
ENSMUST00000254535.1 ENSMUSG00000122734 ENSMUST00000254535.1 ENSMUSG00000122734 (from geneSymbol) uc331xyb.1 uc331xyb.1 
ENSMUST00000254537.1 ENSMUSG00000122735 ENSMUST00000254537.1 ENSMUSG00000122735 (from geneSymbol) uc331xyd.1 uc331xyd.1 
ENSMUST00000254539.1 ENSMUSG00000122736 ENSMUST00000254539.1 ENSMUSG00000122736 (from geneSymbol) uc331xyf.1 uc331xyf.1 
ENSMUST00000254541.1 ENSMUSG00000122737 ENSMUST00000254541.1 ENSMUSG00000122737 (from geneSymbol) uc331xyh.1 uc331xyh.1 
ENSMUST00000254544.1 4930401O10Rik ENSMUST00000254544.1 4930401O10Rik (from geneSymbol) AK015039 uc331xyk.1 uc331xyk.1 
ENSMUST00000254576.1 ENSMUSG00000122738 ENSMUST00000254576.1 ENSMUSG00000122738 (from geneSymbol) uc331xzp.1 uc331xzp.1 
ENSMUST00000254577.1 ENSMUSG00000122739 ENSMUST00000254577.1 ENSMUSG00000122739 (from geneSymbol) uc331xzq.1 uc331xzq.1 
ENSMUST00000254578.1 ENSMUSG00000122740 ENSMUST00000254578.1 ENSMUSG00000122740 (from geneSymbol) uc331xzr.1 uc331xzr.1 
ENSMUST00000254579.1 ENSMUSG00000122741 ENSMUST00000254579.1 ENSMUSG00000122741 (from geneSymbol) uc331xzs.1 uc331xzs.1 
ENSMUST00000254581.1 Gm19583 ENSMUST00000254581.1 Gm19583 (from geneSymbol) AK139774 uc331xzu.1 uc331xzu.1 
ENSMUST00000254588.1 ENSMUSG00000122742 ENSMUST00000254588.1 ENSMUSG00000122742 (from geneSymbol) uc331yab.1 uc331yab.1 
ENSMUST00000254589.1 ENSMUSG00000122743 ENSMUST00000254589.1 ENSMUSG00000122743 (from geneSymbol) uc331yac.1 uc331yac.1 
ENSMUST00000254609.1 Gm30301 ENSMUST00000254609.1 Gm30301 (from geneSymbol) uc331yaw.1 uc331yaw.1 
ENSMUST00000254612.1 ENSMUSG00000122744 ENSMUST00000254612.1 ENSMUSG00000122744 (from geneSymbol) uc331yaz.1 uc331yaz.1 
ENSMUST00000254614.1 ENSMUSG00000122745 ENSMUST00000254614.1 ENSMUSG00000122745 (from geneSymbol) uc331ybb.1 uc331ybb.1 
ENSMUST00000254615.1 ENSMUSG00000122746 ENSMUST00000254615.1 ENSMUSG00000122746 (from geneSymbol) uc331ybc.1 uc331ybc.1 
ENSMUST00000254623.1 ENSMUSG00000122747 ENSMUST00000254623.1 ENSMUSG00000122747 (from geneSymbol) uc331ybk.1 uc331ybk.1 
ENSMUST00000254625.1 Gm12907 ENSMUST00000254625.1 Gm12907 (from geneSymbol) uc331ybm.1 uc331ybm.1 
ENSMUST00000254628.1 ENSMUSG00000122748 ENSMUST00000254628.1 ENSMUSG00000122748 (from geneSymbol) uc331ybp.1 uc331ybp.1 
ENSMUST00000254630.1 Gm48633 ENSMUST00000254630.1 Gm48633 (from geneSymbol) AK146888 uc331ybr.1 uc331ybr.1 
ENSMUST00000254670.1 ENSMUSG00000122749 ENSMUST00000254670.1 ENSMUSG00000122749 (from geneSymbol) uc331ydf.1 uc331ydf.1 
ENSMUST00000254676.1 ENSMUSG00000122750 ENSMUST00000254676.1 ENSMUSG00000122750 (from geneSymbol) uc331ydl.1 uc331ydl.1 
ENSMUST00000254688.1 ENSMUSG00000122751 ENSMUST00000254688.1 ENSMUSG00000122751 (from geneSymbol) uc331ydx.1 uc331ydx.1 
ENSMUST00000254690.1 ENSMUSG00000122752 ENSMUST00000254690.1 ENSMUSG00000122752 (from geneSymbol) uc331ydz.1 uc331ydz.1 
ENSMUST00000254691.1 ENSMUSG00000122753 ENSMUST00000254691.1 ENSMUSG00000122753 (from geneSymbol) uc331yea.1 uc331yea.1 
ENSMUST00000254704.1 ENSMUSG00000122754 ENSMUST00000254704.1 ENSMUSG00000122754 (from geneSymbol) BC099537 uc331yen.1 uc331yen.1 
ENSMUST00000254707.1 Gm56634 ENSMUST00000254707.1 Gm56634 (from geneSymbol) uc331yep.1 uc331yep.1 
ENSMUST00000254713.1 ENSMUSG00000122756 ENSMUST00000254713.1 ENSMUSG00000122756 (from geneSymbol) uc331yev.1 uc331yev.1 
ENSMUST00000254714.1 ENSMUSG00000122757 ENSMUST00000254714.1 ENSMUSG00000122757 (from geneSymbol) uc331yew.1 uc331yew.1 
ENSMUST00000254718.1 ENSMUSG00000122758 ENSMUST00000254718.1 ENSMUSG00000122758 (from geneSymbol) uc331yfa.1 uc331yfa.1 
ENSMUST00000254720.1 ENSMUSG00000122759 ENSMUST00000254720.1 ENSMUSG00000122759 (from geneSymbol) uc331yfc.1 uc331yfc.1 
ENSMUST00000254722.1 ENSMUSG00000122760 ENSMUST00000254722.1 ENSMUSG00000122760 (from geneSymbol) uc331yfe.1 uc331yfe.1 
ENSMUST00000254723.1 ENSMUSG00000122761 ENSMUST00000254723.1 ENSMUSG00000122761 (from geneSymbol) uc331yff.1 uc331yff.1 
ENSMUST00000254724.1 ENSMUSG00000122762 ENSMUST00000254724.1 ENSMUSG00000122762 (from geneSymbol) LF193561 uc331yfg.1 uc331yfg.1 
ENSMUST00000254725.1 ENSMUSG00000122763 ENSMUST00000254725.1 ENSMUSG00000122763 (from geneSymbol) uc331yfh.1 uc331yfh.1 
ENSMUST00000254729.1 ENSMUSG00000122764 ENSMUST00000254729.1 ENSMUSG00000122764 (from geneSymbol) uc331yfl.1 uc331yfl.1 
ENSMUST00000254733.1 Gm38554 ENSMUST00000254733.1 Gm38554 (from geneSymbol) BC049722 uc331yfp.1 uc331yfp.1 
ENSMUST00000254755.1 ENSMUSG00000122765 ENSMUST00000254755.1 ENSMUSG00000122765 (from geneSymbol) uc331ygl.1 uc331ygl.1 
ENSMUST00000254760.1 ENSMUSG00000122766 ENSMUST00000254760.1 ENSMUSG00000122766 (from geneSymbol) uc331ygq.1 uc331ygq.1 
ENSMUST00000254764.1 ENSMUSG00000122767 ENSMUST00000254764.1 ENSMUSG00000122767 (from geneSymbol) uc331ygu.1 uc331ygu.1 
ENSMUST00000254765.1 ENSMUSG00000122768 ENSMUST00000254765.1 ENSMUSG00000122768 (from geneSymbol) uc331ygv.1 uc331ygv.1 
ENSMUST00000254766.1 ENSMUSG00000122769 ENSMUST00000254766.1 ENSMUSG00000122769 (from geneSymbol) uc331ygw.1 uc331ygw.1 
ENSMUST00000254781.1 ENSMUSG00000122770 ENSMUST00000254781.1 ENSMUSG00000122770 (from geneSymbol) uc331yhl.1 uc331yhl.1 
ENSMUST00000254782.1 ENSMUSG00000122771 ENSMUST00000254782.1 ENSMUSG00000122771 (from geneSymbol) uc331yhm.1 uc331yhm.1 
ENSMUST00000254783.1 ENSMUSG00000122772 ENSMUST00000254783.1 ENSMUSG00000122772 (from geneSymbol) uc331yhn.1 uc331yhn.1 
ENSMUST00000254788.1 ENSMUSG00000122773 ENSMUST00000254788.1 ENSMUSG00000122773 (from geneSymbol) uc331yhs.1 uc331yhs.1 
ENSMUST00000254809.1 ENSMUSG00000122774 ENSMUST00000254809.1 ENSMUSG00000122774 (from geneSymbol) uc331yin.1 uc331yin.1 
ENSMUST00000254810.1 ENSMUSG00000122775 ENSMUST00000254810.1 ENSMUSG00000122775 (from geneSymbol) uc331yio.1 uc331yio.1 
ENSMUST00000254811.1 ENSMUSG00000122776 ENSMUST00000254811.1 ENSMUSG00000122776 (from geneSymbol) uc331yip.1 uc331yip.1 
ENSMUST00000254815.1 ENSMUSG00000122777 ENSMUST00000254815.1 ENSMUSG00000122777 (from geneSymbol) uc331yit.1 uc331yit.1 
ENSMUST00000254816.1 ENSMUSG00000122778 ENSMUST00000254816.1 ENSMUSG00000122778 (from geneSymbol) uc331yiu.1 uc331yiu.1 
ENSMUST00000254817.1 ENSMUSG00000122779 ENSMUST00000254817.1 ENSMUSG00000122779 (from geneSymbol) uc331yiv.1 uc331yiv.1 
ENSMUST00000254821.1 ENSMUSG00000122780 ENSMUST00000254821.1 ENSMUSG00000122780 (from geneSymbol) uc331yiz.1 uc331yiz.1 
ENSMUST00000254822.1 ENSMUSG00000122781 ENSMUST00000254822.1 ENSMUSG00000122781 (from geneSymbol) uc331yja.1 uc331yja.1 
ENSMUST00000254823.1 ENSMUSG00000122782 ENSMUST00000254823.1 ENSMUSG00000122782 (from geneSymbol) uc331yjb.1 uc331yjb.1 
ENSMUST00000254825.1 ENSMUSG00000122783 ENSMUST00000254825.1 ENSMUSG00000122783 (from geneSymbol) uc331yjd.1 uc331yjd.1 
ENSMUST00000254827.1 ENSMUSG00000122784 ENSMUST00000254827.1 ENSMUSG00000122784 (from geneSymbol) uc331yjf.1 uc331yjf.1 
ENSMUST00000254828.1 ENSMUSG00000122785 ENSMUST00000254828.1 ENSMUSG00000122785 (from geneSymbol) uc331yjg.1 uc331yjg.1 
ENSMUST00000254829.1 ENSMUSG00000122786 ENSMUST00000254829.1 ENSMUSG00000122786 (from geneSymbol) uc331yjh.1 uc331yjh.1 
ENSMUST00000254830.1 ENSMUSG00000122787 ENSMUST00000254830.1 ENSMUSG00000122787 (from geneSymbol) uc331yji.1 uc331yji.1 
ENSMUST00000254831.1 ENSMUSG00000122788 ENSMUST00000254831.1 ENSMUSG00000122788 (from geneSymbol) uc331yjj.1 uc331yjj.1 
ENSMUST00000254832.1 ENSMUSG00000122789 ENSMUST00000254832.1 ENSMUSG00000122789 (from geneSymbol) uc331yjk.1 uc331yjk.1 
ENSMUST00000254833.1 Gm40741 ENSMUST00000254833.1 Gm40741 (from geneSymbol) uc331yjl.1 uc331yjl.1 
ENSMUST00000254844.1 ENSMUSG00000122790 ENSMUST00000254844.1 ENSMUSG00000122790 (from geneSymbol) uc331yjw.1 uc331yjw.1 
ENSMUST00000254846.1 ENSMUSG00000122791 ENSMUST00000254846.1 ENSMUSG00000122791 (from geneSymbol) uc331yjy.1 uc331yjy.1 
ENSMUST00000254847.1 ENSMUSG00000122792 ENSMUST00000254847.1 ENSMUSG00000122792 (from geneSymbol) uc331yjz.1 uc331yjz.1 
ENSMUST00000254848.1 ENSMUSG00000122793 ENSMUST00000254848.1 ENSMUSG00000122793 (from geneSymbol) uc331yka.1 uc331yka.1 
ENSMUST00000254852.1 ENSMUSG00000122794 ENSMUST00000254852.1 ENSMUSG00000122794 (from geneSymbol) uc331yke.1 uc331yke.1 
ENSMUST00000254858.1 ENSMUSG00000122795 ENSMUST00000254858.1 ENSMUSG00000122795 (from geneSymbol) uc331ykk.1 uc331ykk.1 
ENSMUST00000254859.1 ENSMUSG00000122796 ENSMUST00000254859.1 ENSMUSG00000122796 (from geneSymbol) uc331ykl.1 uc331ykl.1 
ENSMUST00000254873.1 ENSMUSG00000122797 ENSMUST00000254873.1 ENSMUSG00000122797 (from geneSymbol) uc331ykz.1 uc331ykz.1 
ENSMUST00000254874.1 ENSMUSG00000122798 ENSMUST00000254874.1 ENSMUSG00000122798 (from geneSymbol) uc331yla.1 uc331yla.1 
ENSMUST00000254886.1 AV205837 ENSMUST00000254886.1 AV205837 (from geneSymbol) uc331ylm.1 uc331ylm.1 
ENSMUST00000254891.1 ENSMUSG00000122799 ENSMUST00000254891.1 ENSMUSG00000122799 (from geneSymbol) uc331ylr.1 uc331ylr.1 
ENSMUST00000254893.1 ENSMUSG00000122800 ENSMUST00000254893.1 ENSMUSG00000122800 (from geneSymbol) uc331ylt.1 uc331ylt.1 
ENSMUST00000254894.1 ENSMUSG00000122801 ENSMUST00000254894.1 ENSMUSG00000122801 (from geneSymbol) uc331ylu.1 uc331ylu.1 
ENSMUST00000254895.1 ENSMUSG00000122802 ENSMUST00000254895.1 ENSMUSG00000122802 (from geneSymbol) uc331ylv.1 uc331ylv.1 
ENSMUST00000254897.1 ENSMUSG00000122803 ENSMUST00000254897.1 ENSMUSG00000122803 (from geneSymbol) uc331ylx.1 uc331ylx.1 
ENSMUST00000254906.1 ENSMUSG00000122804 ENSMUST00000254906.1 ENSMUSG00000122804 (from geneSymbol) uc331ymg.1 uc331ymg.1 
ENSMUST00000254913.1 ENSMUSG00000122805 ENSMUST00000254913.1 ENSMUSG00000122805 (from geneSymbol) uc331ymn.1 uc331ymn.1 
ENSMUST00000254915.1 ENSMUSG00000122807 ENSMUST00000254915.1 ENSMUSG00000122807 (from geneSymbol) uc331ymo.1 uc331ymo.1 
ENSMUST00000254916.1 ENSMUSG00000122808 ENSMUST00000254916.1 ENSMUSG00000122808 (from geneSymbol) uc331ymp.1 uc331ymp.1 
ENSMUST00000254919.1 ENSMUSG00000122809 ENSMUST00000254919.1 ENSMUSG00000122809 (from geneSymbol) uc331yms.1 uc331yms.1 
ENSMUST00000254920.1 ENSMUSG00000122810 ENSMUST00000254920.1 ENSMUSG00000122810 (from geneSymbol) uc331ymt.1 uc331ymt.1 
ENSMUST00000254923.1 ENSMUSG00000122811 ENSMUST00000254923.1 ENSMUSG00000122811 (from geneSymbol) uc331ymw.1 uc331ymw.1 
ENSMUST00000254927.1 ENSMUSG00000122812 ENSMUST00000254927.1 ENSMUSG00000122812 (from geneSymbol) uc331yna.1 uc331yna.1 
ENSMUST00000254928.1 ENSMUSG00000122813 ENSMUST00000254928.1 ENSMUSG00000122813 (from geneSymbol) uc331ynb.1 uc331ynb.1 
ENSMUST00000254929.1 2310043L19Rik ENSMUST00000254929.1 2310043L19Rik (from geneSymbol) AK009784 uc331ync.1 uc331ync.1 
ENSMUST00000254933.1 1700083H02Rik ENSMUST00000254933.1 1700083H02Rik (from geneSymbol) AK006983 uc331yng.1 uc331yng.1 
ENSMUST00000254937.1 ENSMUSG00000122814 ENSMUST00000254937.1 ENSMUSG00000122814 (from geneSymbol) uc331ynk.1 uc331ynk.1 
ENSMUST00000254940.1 ENSMUSG00000122815 ENSMUST00000254940.1 ENSMUSG00000122815 (from geneSymbol) uc331ynn.1 uc331ynn.1 
ENSMUST00000254941.1 ENSMUSG00000122816 ENSMUST00000254941.1 ENSMUSG00000122816 (from geneSymbol) uc331yno.1 uc331yno.1 
ENSMUST00000254943.1 4933432I03Rik ENSMUST00000254943.1 4933432I03Rik (from geneSymbol) AK017023 uc331ynq.1 uc331ynq.1 
ENSMUST00000254950.1 ENSMUSG00000122817 ENSMUST00000254950.1 ENSMUSG00000122817 (from geneSymbol) uc331ynx.1 uc331ynx.1 
ENSMUST00000254952.1 ENSMUSG00000122818 ENSMUST00000254952.1 ENSMUSG00000122818 (from geneSymbol) uc331ynz.1 uc331ynz.1 
ENSMUST00000254953.1 ENSMUSG00000122819 ENSMUST00000254953.1 ENSMUSG00000122819 (from geneSymbol) uc331yoa.1 uc331yoa.1 
ENSMUST00000254954.1 ENSMUSG00000122820 ENSMUST00000254954.1 ENSMUSG00000122820 (from geneSymbol) uc331yob.1 uc331yob.1 
ENSMUST00000254963.1 ENSMUSG00000122821 ENSMUST00000254963.1 ENSMUSG00000122821 (from geneSymbol) uc331yok.1 uc331yok.1 
ENSMUST00000254968.1 Gm12107 ENSMUST00000254968.1 Gm12107 (from geneSymbol) uc331yop.1 uc331yop.1 
ENSMUST00000254972.1 ENSMUSG00000122822 ENSMUST00000254972.1 ENSMUSG00000122822 (from geneSymbol) uc331yot.1 uc331yot.1 
ENSMUST00000254975.1 ENSMUSG00000122823 ENSMUST00000254975.1 ENSMUSG00000122823 (from geneSymbol) uc331yow.1 uc331yow.1 
ENSMUST00000254985.1 Gm47107 ENSMUST00000254985.1 Gm47107 (from geneSymbol) uc331ypg.1 uc331ypg.1 
ENSMUST00000254997.1 8030423F21Rik ENSMUST00000254997.1 8030423F21Rik (from geneSymbol) AK033101 uc331yps.1 uc331yps.1 
ENSMUST00000255001.1 ENSMUSG00000122824 ENSMUST00000255001.1 ENSMUSG00000122824 (from geneSymbol) uc331ypw.1 uc331ypw.1 
ENSMUST00000255005.1 ENSMUSG00000122825 ENSMUST00000255005.1 ENSMUSG00000122825 (from geneSymbol) uc331yqa.1 uc331yqa.1 
ENSMUST00000255007.1 ENSMUSG00000122827 ENSMUST00000255007.1 ENSMUSG00000122827 (from geneSymbol) uc331yqb.1 uc331yqb.1 
ENSMUST00000255008.1 ENSMUSG00000122828 ENSMUST00000255008.1 ENSMUSG00000122828 (from geneSymbol) uc331yqc.1 uc331yqc.1 
ENSMUST00000255013.1 ENSMUSG00000122829 ENSMUST00000255013.1 ENSMUSG00000122829 (from geneSymbol) uc331yqh.1 uc331yqh.1 
ENSMUST00000255020.1 ENSMUSG00000122831 ENSMUST00000255020.1 ENSMUSG00000122831 (from geneSymbol) uc331yqn.1 uc331yqn.1 
ENSMUST00000255021.1 ENSMUSG00000122832 ENSMUST00000255021.1 ENSMUSG00000122832 (from geneSymbol) uc331yqo.1 uc331yqo.1 
ENSMUST00000255022.1 ENSMUSG00000122833 ENSMUST00000255022.1 ENSMUSG00000122833 (from geneSymbol) uc331yqp.1 uc331yqp.1 
ENSMUST00000255029.1 ENSMUSG00000122834 ENSMUST00000255029.1 ENSMUSG00000122834 (from geneSymbol) uc331yqw.1 uc331yqw.1 
ENSMUST00000255030.1 ENSMUSG00000122835 ENSMUST00000255030.1 ENSMUSG00000122835 (from geneSymbol) uc331yqx.1 uc331yqx.1 
ENSMUST00000255035.1 ENSMUSG00000122836 ENSMUST00000255035.1 ENSMUSG00000122836 (from geneSymbol) uc331yrc.1 uc331yrc.1 
ENSMUST00000255037.1 ENSMUSG00000122837 ENSMUST00000255037.1 ENSMUSG00000122837 (from geneSymbol) uc331yre.1 uc331yre.1 
ENSMUST00000255042.1 ENSMUSG00000122838 ENSMUST00000255042.1 ENSMUSG00000122838 (from geneSymbol) uc331yrj.1 uc331yrj.1 
ENSMUST00000255046.1 ENSMUSG00000122839 ENSMUST00000255046.1 ENSMUSG00000122839 (from geneSymbol) uc331yrn.1 uc331yrn.1 
ENSMUST00000255050.1 ENSMUSG00000122840 ENSMUST00000255050.1 ENSMUSG00000122840 (from geneSymbol) uc331yrr.1 uc331yrr.1 
ENSMUST00000255053.1 ENSMUSG00000122841 ENSMUST00000255053.1 ENSMUSG00000122841 (from geneSymbol) uc331yru.1 uc331yru.1 
ENSMUST00000255059.1 ENSMUSG00000122842 ENSMUST00000255059.1 ENSMUSG00000122842 (from geneSymbol) uc331ysa.1 uc331ysa.1 
ENSMUST00000255061.1 ENSMUSG00000122843 ENSMUST00000255061.1 ENSMUSG00000122843 (from geneSymbol) uc331ysc.1 uc331ysc.1 
ENSMUST00000255068.1 D130058E05Rik ENSMUST00000255068.1 D130058E05Rik (from geneSymbol) AK036422 uc331ysj.1 uc331ysj.1 
ENSMUST00000255087.1 ENSMUSG00000122844 ENSMUST00000255087.1 ENSMUSG00000122844 (from geneSymbol) uc331ytb.1 uc331ytb.1 
ENSMUST00000255092.1 ENSMUSG00000122845 ENSMUST00000255092.1 ENSMUSG00000122845 (from geneSymbol) uc331ytg.1 uc331ytg.1 
ENSMUST00000255099.1 ENSMUSG00000122846 ENSMUST00000255099.1 ENSMUSG00000122846 (from geneSymbol) uc331ytn.1 uc331ytn.1 
ENSMUST00000255106.1 ENSMUSG00000122847 ENSMUST00000255106.1 ENSMUSG00000122847 (from geneSymbol) uc331ytu.1 uc331ytu.1 
ENSMUST00000255115.1 ENSMUSG00000122848 ENSMUST00000255115.1 ENSMUSG00000122848 (from geneSymbol) uc331yud.1 uc331yud.1 
ENSMUST00000255126.1 ENSMUSG00000122849 ENSMUST00000255126.1 ENSMUSG00000122849 (from geneSymbol) uc331yuo.1 uc331yuo.1 
ENSMUST00000255128.1 ENSMUSG00000122850 ENSMUST00000255128.1 ENSMUSG00000122850 (from geneSymbol) uc331yuq.1 uc331yuq.1 
ENSMUST00000255130.1 ENSMUSG00000122851 ENSMUST00000255130.1 ENSMUSG00000122851 (from geneSymbol) uc331yus.1 uc331yus.1 
ENSMUST00000255131.1 Gm33167 ENSMUST00000255131.1 predicted gene, 33167, transcript variant 1 (from RefSeq NR_166598.1) NR_166598 uc331yut.1 uc331yut.1 
ENSMUST00000255136.1 ENSMUSG00000122853 ENSMUST00000255136.1 ENSMUSG00000122853 (from geneSymbol) uc331yuy.1 uc331yuy.1 
ENSMUST00000255139.1 ENSMUSG00000122854 ENSMUST00000255139.1 ENSMUSG00000122854 (from geneSymbol) uc331yvb.1 uc331yvb.1 
ENSMUST00000255148.1 ENSMUSG00000122855 ENSMUST00000255148.1 ENSMUSG00000122855 (from geneSymbol) uc331yvk.1 uc331yvk.1 
ENSMUST00000255149.1 ENSMUSG00000122856 ENSMUST00000255149.1 ENSMUSG00000122856 (from geneSymbol) uc331yvl.1 uc331yvl.1 
ENSMUST00000255150.1 ENSMUSG00000122857 ENSMUST00000255150.1 ENSMUSG00000122857 (from geneSymbol) uc331yvm.1 uc331yvm.1 
ENSMUST00000255152.1 ENSMUSG00000122858 ENSMUST00000255152.1 ENSMUSG00000122858 (from geneSymbol) uc331yvo.1 uc331yvo.1 
ENSMUST00000255153.1 ENSMUSG00000122859 ENSMUST00000255153.1 ENSMUSG00000122859 (from geneSymbol) uc331yvp.1 uc331yvp.1 
ENSMUST00000255154.1 ENSMUSG00000122860 ENSMUST00000255154.1 ENSMUSG00000122860 (from geneSymbol) uc331yvq.1 uc331yvq.1 
ENSMUST00000255155.1 ENSMUSG00000122861 ENSMUST00000255155.1 ENSMUSG00000122861 (from geneSymbol) uc331yvr.1 uc331yvr.1 
ENSMUST00000255157.1 ENSMUSG00000122862 ENSMUST00000255157.1 ENSMUSG00000122862 (from geneSymbol) uc331yvt.1 uc331yvt.1 
ENSMUST00000255158.1 ENSMUSG00000122863 ENSMUST00000255158.1 ENSMUSG00000122863 (from geneSymbol) uc331yvu.1 uc331yvu.1 
ENSMUST00000255159.1 ENSMUSG00000122864 ENSMUST00000255159.1 ENSMUSG00000122864 (from geneSymbol) uc331yvv.1 uc331yvv.1 
ENSMUST00000255162.1 ENSMUSG00000122865 ENSMUST00000255162.1 ENSMUSG00000122865 (from geneSymbol) uc331yvy.1 uc331yvy.1 
ENSMUST00000255163.1 ENSMUSG00000122866 ENSMUST00000255163.1 ENSMUSG00000122866 (from geneSymbol) uc331yvz.1 uc331yvz.1 
ENSMUST00000255165.1 ENSMUSG00000122867 ENSMUST00000255165.1 ENSMUSG00000122867 (from geneSymbol) uc331ywb.1 uc331ywb.1 
ENSMUST00000255167.1 ENSMUSG00000122868 ENSMUST00000255167.1 ENSMUSG00000122868 (from geneSymbol) uc331ywd.1 uc331ywd.1 
ENSMUST00000255168.1 ENSMUSG00000122869 ENSMUST00000255168.1 ENSMUSG00000122869 (from geneSymbol) uc331ywe.1 uc331ywe.1 
ENSMUST00000255170.1 ENSMUSG00000122870 ENSMUST00000255170.1 ENSMUSG00000122870 (from geneSymbol) uc331ywg.1 uc331ywg.1 
ENSMUST00000255171.1 ENSMUSG00000122871 ENSMUST00000255171.1 ENSMUSG00000122871 (from geneSymbol) uc331ywh.1 uc331ywh.1 
ENSMUST00000255172.1 ENSMUSG00000122872 ENSMUST00000255172.1 ENSMUSG00000122872 (from geneSymbol) uc331ywi.1 uc331ywi.1 
ENSMUST00000255184.1 Gm2245 ENSMUST00000255184.1 Gm2245 (from geneSymbol) AK133228 uc331ywu.1 uc331ywu.1 
ENSMUST00000255198.1 ENSMUSG00000122874 ENSMUST00000255198.1 ENSMUSG00000122874 (from geneSymbol) uc331yxh.1 uc331yxh.1 
ENSMUST00000255199.1 ENSMUSG00000122875 ENSMUST00000255199.1 ENSMUSG00000122875 (from geneSymbol) uc331yxi.1 uc331yxi.1 
ENSMUST00000255201.1 ENSMUSG00000122876 ENSMUST00000255201.1 ENSMUSG00000122876 (from geneSymbol) uc331yxk.1 uc331yxk.1 
ENSMUST00000255202.1 Gm32196 ENSMUST00000255202.1 Gm32196 (from geneSymbol) uc331yxl.1 uc331yxl.1 
ENSMUST00000255204.1 ENSMUSG00000122877 ENSMUST00000255204.1 ENSMUSG00000122877 (from geneSymbol) uc331yxn.1 uc331yxn.1 
ENSMUST00000255215.1 Gm37432 ENSMUST00000255215.1 Gm37432 (from geneSymbol) uc331yxy.1 uc331yxy.1 
ENSMUST00000255220.1 ENSMUSG00000122879 ENSMUST00000255220.1 ENSMUSG00000122879 (from geneSymbol) uc331yyc.1 uc331yyc.1 
ENSMUST00000255221.1 ENSMUSG00000122880 ENSMUST00000255221.1 ENSMUSG00000122880 (from geneSymbol) uc331yyd.1 uc331yyd.1 
ENSMUST00000255222.1 ENSMUSG00000122881 ENSMUST00000255222.1 ENSMUSG00000122881 (from geneSymbol) uc331yye.1 uc331yye.1 
ENSMUST00000255224.1 ENSMUSG00000122882 ENSMUST00000255224.1 ENSMUSG00000122882 (from geneSymbol) uc331yyg.1 uc331yyg.1 
ENSMUST00000255225.1 ENSMUSG00000122883 ENSMUST00000255225.1 ENSMUSG00000122883 (from geneSymbol) uc331yyh.1 uc331yyh.1 
ENSMUST00000255226.1 ENSMUSG00000122884 ENSMUST00000255226.1 ENSMUSG00000122884 (from geneSymbol) uc331yyi.1 uc331yyi.1 
ENSMUST00000255228.1 ENSMUSG00000122885 ENSMUST00000255228.1 ENSMUSG00000122885 (from geneSymbol) uc331yyk.1 uc331yyk.1 
ENSMUST00000255239.1 ENSMUSG00000122886 ENSMUST00000255239.1 ENSMUSG00000122886 (from geneSymbol) uc331yyv.1 uc331yyv.1 
ENSMUST00000255241.1 Gm49767 ENSMUST00000255241.1 Gm49767 (from geneSymbol) uc331yyx.1 uc331yyx.1 
ENSMUST00000255246.1 ENSMUSG00000122887 ENSMUST00000255246.1 ENSMUSG00000122887 (from geneSymbol) uc331yzc.1 uc331yzc.1 
ENSMUST00000255252.1 ENSMUSG00000122888 ENSMUST00000255252.1 ENSMUSG00000122888 (from geneSymbol) uc331yzi.1 uc331yzi.1 
ENSMUST00000255257.1 4930592C13Rik ENSMUST00000255257.1 4930592C13Rik (from geneSymbol) AK076987 uc331yzn.1 uc331yzn.1 
ENSMUST00000255263.1 ENSMUSG00000122889 ENSMUST00000255263.1 ENSMUSG00000122889 (from geneSymbol) uc331yzt.1 uc331yzt.1 
ENSMUST00000255264.1 ENSMUSG00000122890 ENSMUST00000255264.1 ENSMUSG00000122890 (from geneSymbol) uc331yzu.1 uc331yzu.1 
ENSMUST00000255266.1 ENSMUSG00000122891 ENSMUST00000255266.1 ENSMUSG00000122891 (from geneSymbol) uc331yzw.1 uc331yzw.1 
ENSMUST00000255272.1 ENSMUSG00000122892 ENSMUST00000255272.1 ENSMUSG00000122892 (from geneSymbol) uc331zac.1 uc331zac.1 
ENSMUST00000255277.1 ENSMUSG00000122893 ENSMUST00000255277.1 ENSMUSG00000122893 (from geneSymbol) uc331zah.1 uc331zah.1 
ENSMUST00000255282.1 ENSMUSG00000122894 ENSMUST00000255282.1 ENSMUSG00000122894 (from geneSymbol) uc331zam.1 uc331zam.1 
ENSMUST00000255284.1 ENSMUSG00000122895 ENSMUST00000255284.1 ENSMUSG00000122895 (from geneSymbol) uc331zao.1 uc331zao.1 
ENSMUST00000255286.1 ENSMUSG00000122896 ENSMUST00000255286.1 ENSMUSG00000122896 (from geneSymbol) uc331zaq.1 uc331zaq.1 
ENSMUST00000255288.1 ENSMUSG00000122897 ENSMUST00000255288.1 ENSMUSG00000122897 (from geneSymbol) uc331zas.1 uc331zas.1 
ENSMUST00000255289.1 ENSMUSG00000122898 ENSMUST00000255289.1 ENSMUSG00000122898 (from geneSymbol) uc331zat.1 uc331zat.1 
ENSMUST00000255290.1 ENSMUSG00000122899 ENSMUST00000255290.1 ENSMUSG00000122899 (from geneSymbol) uc331zau.1 uc331zau.1 
ENSMUST00000255293.1 1700087I21Rik ENSMUST00000255293.1 1700087I21Rik (from geneSymbol) AK139344 uc331zax.1 uc331zax.1 
ENSMUST00000255328.1 ENSMUSG00000122900 ENSMUST00000255328.1 ENSMUSG00000122900 (from geneSymbol) uc331zcg.1 uc331zcg.1 
ENSMUST00000255332.1 ENSMUSG00000122901 ENSMUST00000255332.1 ENSMUSG00000122901 (from geneSymbol) uc331zck.1 uc331zck.1 
ENSMUST00000255334.1 ENSMUSG00000122902 ENSMUST00000255334.1 ENSMUSG00000122902 (from geneSymbol) uc331zcm.1 uc331zcm.1 
ENSMUST00000255335.1 ENSMUSG00000122903 ENSMUST00000255335.1 ENSMUSG00000122903 (from geneSymbol) uc331zcn.1 uc331zcn.1 
ENSMUST00000255336.1 4930506C21Rik ENSMUST00000255336.1 4930506C21Rik (from geneSymbol) AK015714 uc331zco.1 uc331zco.1 
ENSMUST00000255345.1 ENSMUSG00000122904 ENSMUST00000255345.1 ENSMUSG00000122904 (from geneSymbol) uc331zcx.1 uc331zcx.1 
ENSMUST00000255349.1 ENSMUSG00000122905 ENSMUST00000255349.1 ENSMUSG00000122905 (from geneSymbol) BC049966 uc331zdb.1 uc331zdb.1 
ENSMUST00000255350.1 ENSMUSG00000122906 ENSMUST00000255350.1 ENSMUSG00000122906 (from geneSymbol) uc331zdc.1 uc331zdc.1 
ENSMUST00000255351.1 ENSMUSG00000122907 ENSMUST00000255351.1 ENSMUSG00000122907 (from geneSymbol) uc331zdd.1 uc331zdd.1 
ENSMUST00000255352.1 ENSMUSG00000122908 ENSMUST00000255352.1 ENSMUSG00000122908 (from geneSymbol) uc331zde.1 uc331zde.1 
ENSMUST00000255354.1 ENSMUSG00000122909 ENSMUST00000255354.1 ENSMUSG00000122909 (from geneSymbol) uc331zdg.1 uc331zdg.1 
ENSMUST00000255355.1 1700047A11Rik ENSMUST00000255355.1 1700047A11Rik (from geneSymbol) AK006702 uc331zdh.1 uc331zdh.1 
ENSMUST00000255361.1 ENSMUSG00000122910 ENSMUST00000255361.1 ENSMUSG00000122910 (from geneSymbol) uc331zdn.1 uc331zdn.1 
ENSMUST00000255362.1 ENSMUSG00000122911 ENSMUST00000255362.1 ENSMUSG00000122911 (from geneSymbol) uc331zdo.1 uc331zdo.1 
ENSMUST00000255364.1 ENSMUSG00000122912 ENSMUST00000255364.1 ENSMUSG00000122912 (from geneSymbol) uc331zdq.1 uc331zdq.1 
ENSMUST00000255370.1 Gm26879 ENSMUST00000255370.1 Gm26879 (from geneSymbol) AK016486 uc331zdw.1 uc331zdw.1 
ENSMUST00000255375.1 ENSMUSG00000122913 ENSMUST00000255375.1 ENSMUSG00000122913 (from geneSymbol) uc331zeb.1 uc331zeb.1 
ENSMUST00000255377.1 ENSMUSG00000122914 ENSMUST00000255377.1 ENSMUSG00000122914 (from geneSymbol) uc331zed.1 uc331zed.1 
ENSMUST00000255378.1 ENSMUSG00000122915 ENSMUST00000255378.1 ENSMUSG00000122915 (from geneSymbol) uc331zee.1 uc331zee.1 
ENSMUST00000255379.1 ENSMUSG00000122916 ENSMUST00000255379.1 ENSMUSG00000122916 (from geneSymbol) uc331zef.1 uc331zef.1 
ENSMUST00000255380.1 ENSMUSG00000122917 ENSMUST00000255380.1 ENSMUSG00000122917 (from geneSymbol) uc331zeg.1 uc331zeg.1 
ENSMUST00000255382.1 ENSMUSG00000122918 ENSMUST00000255382.1 ENSMUSG00000122918 (from geneSymbol) uc331zei.1 uc331zei.1 
ENSMUST00000255388.1 ENSMUSG00000122919 ENSMUST00000255388.1 ENSMUSG00000122919 (from geneSymbol) uc331zeo.1 uc331zeo.1 
ENSMUST00000255403.1 ENSMUSG00000122920 ENSMUST00000255403.1 ENSMUSG00000122920 (from geneSymbol) uc331zfd.1 uc331zfd.1 
ENSMUST00000255404.1 ENSMUSG00000122921 ENSMUST00000255404.1 ENSMUSG00000122921 (from geneSymbol) uc331zfe.1 uc331zfe.1 
ENSMUST00000255421.1 ENSMUSG00000122922 ENSMUST00000255421.1 ENSMUSG00000122922 (from geneSymbol) uc331zfv.1 uc331zfv.1 
ENSMUST00000255423.1 ENSMUSG00000122923 ENSMUST00000255423.1 ENSMUSG00000122923 (from geneSymbol) uc331zfx.1 uc331zfx.1 
ENSMUST00000255426.1 Gm15496 ENSMUST00000255426.1 Gm15496 (from geneSymbol) AK135877 uc331zga.1 uc331zga.1 
ENSMUST00000255434.1 ENSMUSG00000122924 ENSMUST00000255434.1 ENSMUSG00000122924 (from geneSymbol) uc331zgi.1 uc331zgi.1 
ENSMUST00000255435.1 ENSMUSG00000122925 ENSMUST00000255435.1 ENSMUSG00000122925 (from geneSymbol) uc331zgj.1 uc331zgj.1 
ENSMUST00000255437.1 ENSMUSG00000122926 ENSMUST00000255437.1 ENSMUSG00000122926 (from geneSymbol) uc331zgl.1 uc331zgl.1 
ENSMUST00000255440.1 Gm46560 ENSMUST00000255440.1 Gm46560 (from geneSymbol) uc331zgo.1 uc331zgo.1 
ENSMUST00000255460.1 ENSMUSG00000122927 ENSMUST00000255460.1 ENSMUSG00000122927 (from geneSymbol) uc331zhi.1 uc331zhi.1 
ENSMUST00000255462.1 ENSMUSG00000122928 ENSMUST00000255462.1 ENSMUSG00000122928 (from geneSymbol) uc331zhk.1 uc331zhk.1 
ENSMUST00000255473.1 ENSMUSG00000122929 ENSMUST00000255473.1 ENSMUSG00000122929 (from geneSymbol) uc331zhv.1 uc331zhv.1 
ENSMUST00000255475.1 ENSMUSG00000122930 ENSMUST00000255475.1 ENSMUSG00000122930 (from geneSymbol) uc331zhx.1 uc331zhx.1 
ENSMUST00000255476.1 ENSMUSG00000122931 ENSMUST00000255476.1 ENSMUSG00000122931 (from geneSymbol) uc331zhy.1 uc331zhy.1 
ENSMUST00000255486.1 ENSMUSG00000122932 ENSMUST00000255486.1 ENSMUSG00000122932 (from geneSymbol) uc331zii.1 uc331zii.1 
ENSMUST00000255487.1 ENSMUSG00000122933 ENSMUST00000255487.1 ENSMUSG00000122933 (from geneSymbol) uc331zij.1 uc331zij.1 
ENSMUST00000255490.1 ENSMUSG00000122934 ENSMUST00000255490.1 ENSMUSG00000122934 (from geneSymbol) uc331zim.1 uc331zim.1 
ENSMUST00000255492.1 Gm45012 ENSMUST00000255492.1 Gm45012 (from geneSymbol) AK040908 uc331zio.1 uc331zio.1 
ENSMUST00000255497.1 ENSMUSG00000122935 ENSMUST00000255497.1 ENSMUSG00000122935 (from geneSymbol) uc331zit.1 uc331zit.1 
ENSMUST00000255499.1 ENSMUSG00000122937 ENSMUST00000255499.1 ENSMUSG00000122937 (from geneSymbol) uc331ziu.1 uc331ziu.1 
ENSMUST00000255500.1 ENSMUSG00000122938 ENSMUST00000255500.1 ENSMUSG00000122938 (from geneSymbol) uc331ziv.1 uc331ziv.1 
ENSMUST00000255502.1 ENSMUSG00000122939 ENSMUST00000255502.1 ENSMUSG00000122939 (from geneSymbol) uc331zix.1 uc331zix.1 
ENSMUST00000255503.1 ENSMUSG00000122940 ENSMUST00000255503.1 ENSMUSG00000122940 (from geneSymbol) uc331ziy.1 uc331ziy.1 
ENSMUST00000255506.1 ENSMUSG00000122941 ENSMUST00000255506.1 ENSMUSG00000122941 (from geneSymbol) uc331zjb.1 uc331zjb.1 
ENSMUST00000255515.1 ENSMUSG00000122942 ENSMUST00000255515.1 ENSMUSG00000122942 (from geneSymbol) uc331zjk.1 uc331zjk.1 
ENSMUST00000255516.1 ENSMUSG00000122943 ENSMUST00000255516.1 ENSMUSG00000122943 (from geneSymbol) uc331zjl.1 uc331zjl.1 
ENSMUST00000255517.1 ENSMUSG00000122944 ENSMUST00000255517.1 ENSMUSG00000122944 (from geneSymbol) uc331zjm.1 uc331zjm.1 
ENSMUST00000255521.1 ENSMUSG00000122945 ENSMUST00000255521.1 ENSMUSG00000122945 (from geneSymbol) uc331zjq.1 uc331zjq.1 
ENSMUST00000255522.1 ENSMUSG00000122946 ENSMUST00000255522.1 ENSMUSG00000122946 (from geneSymbol) uc331zjr.1 uc331zjr.1 
ENSMUST00000255525.1 ENSMUSG00000122947 ENSMUST00000255525.1 ENSMUSG00000122947 (from geneSymbol) uc331zju.1 uc331zju.1 
ENSMUST00000255533.1 Gm34907 ENSMUST00000255533.1 Gm34907 (from geneSymbol) AK079958 uc331zkb.1 uc331zkb.1 
ENSMUST00000255546.1 ENSMUSG00000122948 ENSMUST00000255546.1 ENSMUSG00000122948 (from geneSymbol) uc331zko.1 uc331zko.1 
ENSMUST00000255547.1 ENSMUSG00000122949 ENSMUST00000255547.1 ENSMUSG00000122949 (from geneSymbol) AK028328 uc331zkp.1 uc331zkp.1 
ENSMUST00000255550.1 Gm35742 ENSMUST00000255550.1 Gm35742 (from geneSymbol) KY467524 uc331zks.1 uc331zks.1 
ENSMUST00000255559.1 ENSMUSG00000122950 ENSMUST00000255559.1 ENSMUSG00000122950 (from geneSymbol) uc331zlb.1 uc331zlb.1 
ENSMUST00000255563.1 ENSMUSG00000122951 ENSMUST00000255563.1 ENSMUSG00000122951 (from geneSymbol) uc331zlf.1 uc331zlf.1 
ENSMUST00000255565.1 ENSMUSG00000122952 ENSMUST00000255565.1 ENSMUSG00000122952 (from geneSymbol) DQ713556 uc331zlh.1 uc331zlh.1 
ENSMUST00000255566.1 ENSMUSG00000122953 ENSMUST00000255566.1 ENSMUSG00000122953 (from geneSymbol) uc331zli.1 uc331zli.1 
ENSMUST00000255567.1 ENSMUSG00000122954 ENSMUST00000255567.1 ENSMUSG00000122954 (from geneSymbol) DQ694443 uc331zlj.1 uc331zlj.1 
ENSMUST00000255568.1 ENSMUSG00000122955 ENSMUST00000255568.1 ENSMUSG00000122955 (from geneSymbol) uc331zlk.1 uc331zlk.1 
ENSMUST00000255570.1 ENSMUSG00000122956 ENSMUST00000255570.1 ENSMUSG00000122956 (from geneSymbol) uc331zlm.1 uc331zlm.1 
ENSMUST00000255582.1 Gm28857 ENSMUST00000255582.1 Gm28857 (from geneSymbol) uc331zly.1 uc331zly.1 
ENSMUST00000255598.1 ENSMUSG00000122957 ENSMUST00000255598.1 ENSMUSG00000122957 (from geneSymbol) uc331zmo.1 uc331zmo.1 
ENSMUST00000255599.1 ENSMUSG00000122958 ENSMUST00000255599.1 ENSMUSG00000122958 (from geneSymbol) uc331zmp.1 uc331zmp.1 
ENSMUST00000255601.1 ENSMUSG00000122959 ENSMUST00000255601.1 ENSMUSG00000122959 (from geneSymbol) uc331zmr.1 uc331zmr.1 
ENSMUST00000255603.1 ENSMUSG00000122960 ENSMUST00000255603.1 ENSMUSG00000122960 (from geneSymbol) uc331zmt.1 uc331zmt.1 
ENSMUST00000255605.1 Gm12100 ENSMUST00000255605.1 Gm12100 (from geneSymbol) AK049252 uc331zmv.1 uc331zmv.1 
ENSMUST00000255618.1 ENSMUSG00000122961 ENSMUST00000255618.1 ENSMUSG00000122961 (from geneSymbol) uc331zni.1 uc331zni.1 
ENSMUST00000255619.1 ENSMUSG00000122962 ENSMUST00000255619.1 ENSMUSG00000122962 (from geneSymbol) uc331znj.1 uc331znj.1 
ENSMUST00000255622.1 Gm56821 ENSMUST00000255622.1 Gm56821 (from geneSymbol) uc331znm.1 uc331znm.1 
ENSMUST00000255654.1 ENSMUSG00000122964 ENSMUST00000255654.1 ENSMUSG00000122964 (from geneSymbol) uc331zos.1 uc331zos.1 
ENSMUST00000255663.1 ENSMUSG00000122965 ENSMUST00000255663.1 ENSMUSG00000122965 (from geneSymbol) uc331zpb.1 uc331zpb.1 
ENSMUST00000255686.1 Gm38025 ENSMUST00000255686.1 Gm38025 (from geneSymbol) AK139932 uc331zpy.1 uc331zpy.1 
ENSMUST00000255687.1 ENSMUSG00000122966 ENSMUST00000255687.1 ENSMUSG00000122966 (from geneSymbol) uc331zpz.1 uc331zpz.1 
ENSMUST00000255691.1 ENSMUSG00000122967 ENSMUST00000255691.1 ENSMUSG00000122967 (from geneSymbol) uc331zqd.1 uc331zqd.1 
ENSMUST00000255693.1 ENSMUSG00000122968 ENSMUST00000255693.1 ENSMUSG00000122968 (from geneSymbol) LF195034 uc331zqf.1 uc331zqf.1 
ENSMUST00000255694.1 ENSMUSG00000122969 ENSMUST00000255694.1 ENSMUSG00000122969 (from geneSymbol) uc331zqg.1 uc331zqg.1 
ENSMUST00000255696.1 ENSMUSG00000122970 ENSMUST00000255696.1 ENSMUSG00000122970 (from geneSymbol) uc331zqi.1 uc331zqi.1 
ENSMUST00000255697.1 ENSMUSG00000122971 ENSMUST00000255697.1 ENSMUSG00000122971 (from geneSymbol) uc331zqj.1 uc331zqj.1 
ENSMUST00000255699.1 ENSMUSG00000122973 ENSMUST00000255699.1 ENSMUSG00000122973 (from geneSymbol) uc331zqk.1 uc331zqk.1 
ENSMUST00000255702.1 ENSMUSG00000122974 ENSMUST00000255702.1 ENSMUSG00000122974 (from geneSymbol) uc331zqn.1 uc331zqn.1 
ENSMUST00000255704.1 ENSMUSG00000122975 ENSMUST00000255704.1 ENSMUSG00000122975 (from geneSymbol) uc331zqp.1 uc331zqp.1 
ENSMUST00000255706.1 ENSMUSG00000122976 ENSMUST00000255706.1 ENSMUSG00000122976 (from geneSymbol) uc331zqr.1 uc331zqr.1 
ENSMUST00000255708.1 ENSMUSG00000122977 ENSMUST00000255708.1 ENSMUSG00000122977 (from geneSymbol) uc331zqt.1 uc331zqt.1 
ENSMUST00000255709.1 ENSMUSG00000122978 ENSMUST00000255709.1 ENSMUSG00000122978 (from geneSymbol) uc331zqu.1 uc331zqu.1 
ENSMUST00000255710.1 ENSMUSG00000122979 ENSMUST00000255710.1 ENSMUSG00000122979 (from geneSymbol) uc331zqv.1 uc331zqv.1 
ENSMUST00000255712.1 ENSMUSG00000122980 ENSMUST00000255712.1 ENSMUSG00000122980 (from geneSymbol) uc331zqx.1 uc331zqx.1 
ENSMUST00000255724.1 ENSMUSG00000122981 ENSMUST00000255724.1 ENSMUSG00000122981 (from geneSymbol) uc331zrj.1 uc331zrj.1 
ENSMUST00000255727.1 ENSMUSG00000122982 ENSMUST00000255727.1 ENSMUSG00000122982 (from geneSymbol) uc331zrm.1 uc331zrm.1 
ENSMUST00000255731.1 ENSMUSG00000122983 ENSMUST00000255731.1 ENSMUSG00000122983 (from geneSymbol) uc331zrq.1 uc331zrq.1 
ENSMUST00000255745.1 ENSMUSG00000122984 ENSMUST00000255745.1 ENSMUSG00000122984 (from geneSymbol) uc331zse.1 uc331zse.1 
ENSMUST00000255746.1 ENSMUSG00000122985 ENSMUST00000255746.1 ENSMUSG00000122985 (from geneSymbol) uc331zsf.1 uc331zsf.1 
ENSMUST00000255747.1 ENSMUSG00000122986 ENSMUST00000255747.1 ENSMUSG00000122986 (from geneSymbol) uc331zsg.1 uc331zsg.1 
ENSMUST00000255748.1 ENSMUSG00000122987 ENSMUST00000255748.1 ENSMUSG00000122987 (from geneSymbol) uc331zsh.1 uc331zsh.1 
ENSMUST00000255761.1 ENSMUSG00000122988 ENSMUST00000255761.1 ENSMUSG00000122988 (from geneSymbol) uc331zsu.1 uc331zsu.1 
ENSMUST00000255762.1 ENSMUSG00000122989 ENSMUST00000255762.1 ENSMUSG00000122989 (from geneSymbol) uc331zsv.1 uc331zsv.1 
ENSMUST00000255764.1 ENSMUSG00000122990 ENSMUST00000255764.1 ENSMUSG00000122990 (from geneSymbol) uc331zsx.1 uc331zsx.1 
ENSMUST00000255765.1 ENSMUSG00000122991 ENSMUST00000255765.1 ENSMUSG00000122991 (from geneSymbol) uc331zsy.1 uc331zsy.1 
ENSMUST00000255766.1 ENSMUSG00000122992 ENSMUST00000255766.1 ENSMUSG00000122992 (from geneSymbol) uc331zsz.1 uc331zsz.1 
ENSMUST00000255767.1 ENSMUSG00000122993 ENSMUST00000255767.1 ENSMUSG00000122993 (from geneSymbol) uc331zta.1 uc331zta.1 
ENSMUST00000255768.1 ENSMUSG00000122994 ENSMUST00000255768.1 ENSMUSG00000122994 (from geneSymbol) uc331ztb.1 uc331ztb.1 
ENSMUST00000255769.1 ENSMUSG00000122995 ENSMUST00000255769.1 ENSMUSG00000122995 (from geneSymbol) uc331ztc.1 uc331ztc.1 
ENSMUST00000255770.1 ENSMUSG00000122996 ENSMUST00000255770.1 ENSMUSG00000122996 (from geneSymbol) uc331ztd.1 uc331ztd.1 
ENSMUST00000255772.1 ENSMUSG00000122997 ENSMUST00000255772.1 ENSMUSG00000122997 (from geneSymbol) uc331ztf.1 uc331ztf.1 
ENSMUST00000255773.1 ENSMUSG00000122998 ENSMUST00000255773.1 ENSMUSG00000122998 (from geneSymbol) uc331ztg.1 uc331ztg.1 
ENSMUST00000255774.1 ENSMUSG00000122999 ENSMUST00000255774.1 ENSMUSG00000122999 (from geneSymbol) uc331zth.1 uc331zth.1 
ENSMUST00000255775.1 ENSMUSG00000123000 ENSMUST00000255775.1 ENSMUSG00000123000 (from geneSymbol) uc331zti.1 uc331zti.1 
ENSMUST00000255800.1 ENSMUSG00000123001 ENSMUST00000255800.1 ENSMUSG00000123001 (from geneSymbol) uc331zua.1 uc331zua.1 
ENSMUST00000255801.1 ENSMUSG00000123002 ENSMUST00000255801.1 ENSMUSG00000123002 (from geneSymbol) uc331zub.1 uc331zub.1 
ENSMUST00000255802.1 ENSMUSG00000123003 ENSMUST00000255802.1 ENSMUSG00000123003 (from geneSymbol) uc331zuc.1 uc331zuc.1 
ENSMUST00000255803.1 ENSMUSG00000123004 ENSMUST00000255803.1 ENSMUSG00000123004 (from geneSymbol) uc331zud.1 uc331zud.1 
ENSMUST00000255804.1 ENSMUSG00000123005 ENSMUST00000255804.1 ENSMUSG00000123005 (from geneSymbol) uc331zue.1 uc331zue.1 
ENSMUST00000255805.1 ENSMUSG00000123006 ENSMUST00000255805.1 ENSMUSG00000123006 (from geneSymbol) uc331zuf.1 uc331zuf.1 
ENSMUST00000255807.1 ENSMUSG00000123007 ENSMUST00000255807.1 ENSMUSG00000123007 (from geneSymbol) uc331zuh.1 uc331zuh.1 
ENSMUST00000255808.1 ENSMUSG00000123008 ENSMUST00000255808.1 ENSMUSG00000123008 (from geneSymbol) uc331zui.1 uc331zui.1 
ENSMUST00000255810.1 ENSMUSG00000123010 ENSMUST00000255810.1 ENSMUSG00000123010 (from geneSymbol) uc331zuj.1 uc331zuj.1 
ENSMUST00000255811.1 ENSMUSG00000123011 ENSMUST00000255811.1 ENSMUSG00000123011 (from geneSymbol) uc331zuk.1 uc331zuk.1 
ENSMUST00000255812.1 4930539M17Rik ENSMUST00000255812.1 4930539M17Rik (from geneSymbol) AK016002 uc331zul.1 uc331zul.1 
ENSMUST00000255815.1 ENSMUSG00000123012 ENSMUST00000255815.1 ENSMUSG00000123012 (from geneSymbol) uc331zuo.1 uc331zuo.1 
ENSMUST00000255821.1 ENSMUSG00000123013 ENSMUST00000255821.1 ENSMUSG00000123013 (from geneSymbol) uc331zuu.1 uc331zuu.1 
ENSMUST00000255824.1 Gm37233 ENSMUST00000255824.1 Gm37233 (from geneSymbol) uc331zuv.1 uc331zuv.1 
ENSMUST00000255831.1 ENSMUSG00000123014 ENSMUST00000255831.1 ENSMUSG00000123014 (from geneSymbol) uc331zvc.1 uc331zvc.1 
ENSMUST00000255835.1 ENSMUSG00000123015 ENSMUST00000255835.1 ENSMUSG00000123015 (from geneSymbol) uc331zvg.1 uc331zvg.1 
ENSMUST00000255836.1 ENSMUSG00000123016 ENSMUST00000255836.1 ENSMUSG00000123016 (from geneSymbol) uc331zvh.1 uc331zvh.1 
ENSMUST00000255838.1 ENSMUSG00000123017 ENSMUST00000255838.1 ENSMUSG00000123017 (from geneSymbol) uc331zvj.1 uc331zvj.1 
ENSMUST00000255839.1 ENSMUSG00000123018 ENSMUST00000255839.1 ENSMUSG00000123018 (from geneSymbol) uc331zvk.1 uc331zvk.1 
ENSMUST00000255854.1 8430430B14Rik ENSMUST00000255854.1 8430430B14Rik (from geneSymbol) AK020236 uc331zvz.1 uc331zvz.1 
ENSMUST00000255862.1 ENSMUSG00000123019 ENSMUST00000255862.1 ENSMUSG00000123019 (from geneSymbol) uc331zwh.1 uc331zwh.1 
ENSMUST00000255868.1 ENSMUSG00000123020 ENSMUST00000255868.1 ENSMUSG00000123020 (from geneSymbol) uc331zwn.1 uc331zwn.1 
ENSMUST00000255879.1 Gm42800 ENSMUST00000255879.1 Gm42800 (from geneSymbol) uc331zwy.1 uc331zwy.1 
ENSMUST00000255885.1 ENSMUSG00000123021 ENSMUST00000255885.1 ENSMUSG00000123021 (from geneSymbol) uc331zxe.1 uc331zxe.1 
ENSMUST00000255887.1 ENSMUSG00000123022 ENSMUST00000255887.1 ENSMUSG00000123022 (from geneSymbol) uc331zxg.1 uc331zxg.1 
ENSMUST00000255888.1 Gm48311 ENSMUST00000255888.1 Gm48311 (from geneSymbol) uc331zxh.1 uc331zxh.1 
ENSMUST00000255889.1 ENSMUSG00000123023 ENSMUST00000255889.1 ENSMUSG00000123023 (from geneSymbol) uc331zxi.1 uc331zxi.1 
ENSMUST00000255893.1 Gm44621 ENSMUST00000255893.1 Gm44621 (from geneSymbol) uc331zxm.1 uc331zxm.1 
ENSMUST00000255899.1 Gm17518 ENSMUST00000255899.1 predicted gene, 17518, transcript variant 1 (from RefSeq NR_175393.1) NR_175393 uc331zxs.1 uc331zxs.1 
ENSMUST00000255908.1 ENSMUSG00000123024 ENSMUST00000255908.1 ENSMUSG00000123024 (from geneSymbol) uc331zyb.1 uc331zyb.1 
ENSMUST00000255910.1 ENSMUSG00000123025 ENSMUST00000255910.1 ENSMUSG00000123025 (from geneSymbol) uc331zyd.1 uc331zyd.1 
ENSMUST00000255911.1 ENSMUSG00000123026 ENSMUST00000255911.1 ENSMUSG00000123026 (from geneSymbol) uc331zye.1 uc331zye.1 
ENSMUST00000255912.1 ENSMUSG00000123027 ENSMUST00000255912.1 ENSMUSG00000123027 (from geneSymbol) uc331zyf.1 uc331zyf.1 
ENSMUST00000255913.1 ENSMUSG00000123028 ENSMUST00000255913.1 ENSMUSG00000123028 (from geneSymbol) uc331zyg.1 uc331zyg.1 
ENSMUST00000255914.1 ENSMUSG00000123029 ENSMUST00000255914.1 ENSMUSG00000123029 (from geneSymbol) uc331zyh.1 uc331zyh.1 
ENSMUST00000255915.1 ENSMUSG00000123030 ENSMUST00000255915.1 ENSMUSG00000123030 (from geneSymbol) uc331zyi.1 uc331zyi.1 
ENSMUST00000255916.1 ENSMUSG00000123031 ENSMUST00000255916.1 ENSMUSG00000123031 (from geneSymbol) AK139719 uc331zyj.1 uc331zyj.1 
ENSMUST00000255941.1 ENSMUSG00000123032 ENSMUST00000255941.1 ENSMUSG00000123032 (from geneSymbol) uc331zzi.1 uc331zzi.1 
ENSMUST00000255942.1 ENSMUSG00000123033 ENSMUST00000255942.1 ENSMUSG00000123033 (from geneSymbol) uc331zzj.1 uc331zzj.1 
ENSMUST00000255943.1 ENSMUSG00000123034 ENSMUST00000255943.1 ENSMUSG00000123034 (from geneSymbol) uc331zzk.1 uc331zzk.1 
ENSMUST00000255953.1 ENSMUSG00000123035 ENSMUST00000255953.1 ENSMUSG00000123035 (from geneSymbol) uc331zzu.1 uc331zzu.1 
ENSMUST00000255956.1 ENSMUSG00000123036 ENSMUST00000255956.1 ENSMUSG00000123036 (from geneSymbol) uc331zzx.1 uc331zzx.1 
ENSMUST00000255962.1 ENSMUSG00000123037 ENSMUST00000255962.1 ENSMUSG00000123037 (from geneSymbol) uc332aad.1 uc332aad.1 
ENSMUST00000255966.1 ENSMUSG00000123038 ENSMUST00000255966.1 ENSMUSG00000123038 (from geneSymbol) uc332aah.1 uc332aah.1 
ENSMUST00000255977.1 ENSMUSG00000123039 ENSMUST00000255977.1 ENSMUSG00000123039 (from geneSymbol) AK019510 uc332aas.1 uc332aas.1 
ENSMUST00000255978.1 ENSMUSG00000123040 ENSMUST00000255978.1 ENSMUSG00000123040 (from geneSymbol) uc332aat.1 uc332aat.1 
ENSMUST00000255979.1 ENSMUSG00000123041 ENSMUST00000255979.1 ENSMUSG00000123041 (from geneSymbol) uc332aau.1 uc332aau.1 
ENSMUST00000255981.1 ENSMUSG00000123042 ENSMUST00000255981.1 ENSMUSG00000123042 (from geneSymbol) uc332aaw.1 uc332aaw.1 
ENSMUST00000255983.1 ENSMUSG00000123043 ENSMUST00000255983.1 ENSMUSG00000123043 (from geneSymbol) uc332aay.1 uc332aay.1 
ENSMUST00000255984.1 ENSMUSG00000123044 ENSMUST00000255984.1 ENSMUSG00000123044 (from geneSymbol) uc332aaz.1 uc332aaz.1 
ENSMUST00000255985.1 A330035P11Rik ENSMUST00000255985.1 RIKEN cDNA A330035P11 gene (from RefSeq NR_015586.3) NR_015586 uc332aba.1 uc332aba.1 
ENSMUST00000255996.1 ENSMUSG00000123045 ENSMUST00000255996.1 ENSMUSG00000123045 (from geneSymbol) uc332abl.1 uc332abl.1 
ENSMUST00000256000.1 ENSMUSG00000123046 ENSMUST00000256000.1 ENSMUSG00000123046 (from geneSymbol) uc332abp.1 uc332abp.1 
ENSMUST00000256001.1 ENSMUSG00000123047 ENSMUST00000256001.1 ENSMUSG00000123047 (from geneSymbol) uc332abq.1 uc332abq.1 
ENSMUST00000256002.1 ENSMUSG00000123048 ENSMUST00000256002.1 ENSMUSG00000123048 (from geneSymbol) uc332abr.1 uc332abr.1 
ENSMUST00000256003.1 ENSMUSG00000123049 ENSMUST00000256003.1 ENSMUSG00000123049 (from geneSymbol) uc332abs.1 uc332abs.1 
ENSMUST00000256004.1 ENSMUSG00000123050 ENSMUST00000256004.1 ENSMUSG00000123050 (from geneSymbol) uc332abt.1 uc332abt.1 
ENSMUST00000256009.1 4930544I03Rik ENSMUST00000256009.1 4930544I03Rik (from geneSymbol) AK132687 uc332aby.1 uc332aby.1 
ENSMUST00000256027.1 ENSMUSG00000123051 ENSMUST00000256027.1 ENSMUSG00000123051 (from geneSymbol) uc332acq.1 uc332acq.1 
ENSMUST00000256028.1 ENSMUSG00000123052 ENSMUST00000256028.1 ENSMUSG00000123052 (from geneSymbol) uc332acr.1 uc332acr.1 
ENSMUST00000256029.1 ENSMUSG00000123053 ENSMUST00000256029.1 ENSMUSG00000123053 (from geneSymbol) uc332acs.1 uc332acs.1 
ENSMUST00000256030.1 Gm47950 ENSMUST00000256030.1 Gm47950 (from geneSymbol) AK016042 uc332act.1 uc332act.1 
ENSMUST00000256031.1 ENSMUSG00000123054 ENSMUST00000256031.1 ENSMUSG00000123054 (from geneSymbol) uc332acu.1 uc332acu.1 
ENSMUST00000256032.1 ENSMUSG00000123055 ENSMUST00000256032.1 ENSMUSG00000123055 (from geneSymbol) uc332acv.1 uc332acv.1 
ENSMUST00000256034.1 ENSMUSG00000123056 ENSMUST00000256034.1 ENSMUSG00000123056 (from geneSymbol) AK016790 uc332acx.1 uc332acx.1 
ENSMUST00000256035.1 ENSMUSG00000123057 ENSMUST00000256035.1 ENSMUSG00000123057 (from geneSymbol) uc332acy.1 uc332acy.1 
ENSMUST00000256036.1 ENSMUSG00000123058 ENSMUST00000256036.1 ENSMUSG00000123058 (from geneSymbol) uc332acz.1 uc332acz.1 
ENSMUST00000256037.1 ENSMUSG00000123059 ENSMUST00000256037.1 ENSMUSG00000123059 (from geneSymbol) uc332ada.1 uc332ada.1 
ENSMUST00000256042.1 ENSMUSG00000123060 ENSMUST00000256042.1 ENSMUSG00000123060 (from geneSymbol) uc332adf.1 uc332adf.1 
ENSMUST00000256046.1 4930518J21Rik ENSMUST00000256046.1 4930518J21Rik (from geneSymbol) AK015830 uc332adj.1 uc332adj.1 
ENSMUST00000256061.1 ENSMUSG00000123061 ENSMUST00000256061.1 ENSMUSG00000123061 (from geneSymbol) uc332ady.1 uc332ady.1 
ENSMUST00000256063.1 ENSMUSG00000123062 ENSMUST00000256063.1 ENSMUSG00000123062 (from geneSymbol) uc332aea.1 uc332aea.1 
ENSMUST00000256070.1 Gm19582 ENSMUST00000256070.1 Gm19582 (from geneSymbol) uc332aeh.1 uc332aeh.1 
ENSMUST00000256071.1 ENSMUSG00000123063 ENSMUST00000256071.1 ENSMUSG00000123063 (from geneSymbol) uc332aei.1 uc332aei.1 
ENSMUST00000256073.1 ENSMUSG00000123064 ENSMUST00000256073.1 ENSMUSG00000123064 (from geneSymbol) uc332aek.1 uc332aek.1 
ENSMUST00000256074.1 ENSMUSG00000123065 ENSMUST00000256074.1 ENSMUSG00000123065 (from geneSymbol) uc332ael.1 uc332ael.1 
ENSMUST00000256076.1 ENSMUSG00000123066 ENSMUST00000256076.1 ENSMUSG00000123066 (from geneSymbol) uc332aen.1 uc332aen.1 
ENSMUST00000256078.1 ENSMUSG00000123067 ENSMUST00000256078.1 ENSMUSG00000123067 (from geneSymbol) uc332aep.1 uc332aep.1 
ENSMUST00000256080.1 ENSMUSG00000123068 ENSMUST00000256080.1 ENSMUSG00000123068 (from geneSymbol) uc332aer.1 uc332aer.1 
ENSMUST00000256081.1 ENSMUSG00000123069 ENSMUST00000256081.1 ENSMUSG00000123069 (from geneSymbol) uc332aes.1 uc332aes.1 
ENSMUST00000256086.1 ENSMUSG00000123070 ENSMUST00000256086.1 ENSMUSG00000123070 (from geneSymbol) uc332aex.1 uc332aex.1 
ENSMUST00000256088.1 ENSMUSG00000123071 ENSMUST00000256088.1 ENSMUSG00000123071 (from geneSymbol) BC089467 uc332aez.1 uc332aez.1 
ENSMUST00000256090.1 ENSMUSG00000123072 ENSMUST00000256090.1 ENSMUSG00000123072 (from geneSymbol) uc332afb.1 uc332afb.1 
ENSMUST00000256094.1 ENSMUSG00000123073 ENSMUST00000256094.1 ENSMUSG00000123073 (from geneSymbol) uc332aff.1 uc332aff.1 
ENSMUST00000256095.1 ENSMUSG00000123074 ENSMUST00000256095.1 ENSMUSG00000123074 (from geneSymbol) uc332afg.1 uc332afg.1 
ENSMUST00000256098.1 ENSMUSG00000123075 ENSMUST00000256098.1 ENSMUSG00000123075 (from geneSymbol) uc332afj.1 uc332afj.1 
ENSMUST00000256099.1 ENSMUSG00000123076 ENSMUST00000256099.1 ENSMUSG00000123076 (from geneSymbol) uc332afk.1 uc332afk.1 
ENSMUST00000256100.1 ENSMUSG00000123077 ENSMUST00000256100.1 ENSMUSG00000123077 (from geneSymbol) uc332afl.1 uc332afl.1 
ENSMUST00000256102.1 ENSMUSG00000123078 ENSMUST00000256102.1 ENSMUSG00000123078 (from geneSymbol) AK076725 uc332afn.1 uc332afn.1 
ENSMUST00000256103.1 ENSMUSG00000123079 ENSMUST00000256103.1 ENSMUSG00000123079 (from geneSymbol) uc332afo.1 uc332afo.1 
ENSMUST00000256104.1 ENSMUSG00000123080 ENSMUST00000256104.1 ENSMUSG00000123080 (from geneSymbol) uc332afp.1 uc332afp.1 
ENSMUST00000256105.1 ENSMUSG00000123081 ENSMUST00000256105.1 ENSMUSG00000123081 (from geneSymbol) uc332afq.1 uc332afq.1 
ENSMUST00000256106.1 Gm51860 ENSMUST00000256106.1 predicted gene, 51860 (from RefSeq NR_168696.1) NR_168696 uc332afr.1 uc332afr.1 
ENSMUST00000256110.1 ENSMUSG00000123083 ENSMUST00000256110.1 ENSMUSG00000123083 (from geneSymbol) uc332afv.1 uc332afv.1 
ENSMUST00000256118.1 ENSMUSG00000123086 ENSMUST00000256118.1 ENSMUSG00000123086 (from geneSymbol) uc332afx.1 uc332afx.1 
ENSMUST00000256119.1 ENSMUSG00000123087 ENSMUST00000256119.1 ENSMUSG00000123087 (from geneSymbol) uc332afy.1 uc332afy.1 
ENSMUST00000256124.1 ENSMUSG00000123088 ENSMUST00000256124.1 ENSMUSG00000123088 (from geneSymbol) uc332agd.1 uc332agd.1 
ENSMUST00000256127.1 ENSMUSG00000123089 ENSMUST00000256127.1 ENSMUSG00000123089 (from geneSymbol) LF193350 uc332agg.1 uc332agg.1 
ENSMUST00000256129.1 ENSMUSG00000123090 ENSMUST00000256129.1 ENSMUSG00000123090 (from geneSymbol) uc332agi.1 uc332agi.1 
ENSMUST00000256130.1 ENSMUSG00000123091 ENSMUST00000256130.1 ENSMUSG00000123091 (from geneSymbol) AK141077 uc332agj.1 uc332agj.1 
ENSMUST00000256132.1 Gm33489 ENSMUST00000256132.1 Gm33489 (from geneSymbol) AK146979 uc332agl.1 uc332agl.1 
ENSMUST00000256140.1 ENSMUSG00000123092 ENSMUST00000256140.1 ENSMUSG00000123092 (from geneSymbol) uc332agt.1 uc332agt.1 
ENSMUST00000256148.1 ENSMUSG00000123093 ENSMUST00000256148.1 ENSMUSG00000123093 (from geneSymbol) uc332ahb.1 uc332ahb.1 
ENSMUST00000256153.1 Gm15743 ENSMUST00000256153.1 Gm15743 (from geneSymbol) uc332ahg.1 uc332ahg.1 
ENSMUST00000256155.1 ENSMUSG00000123094 ENSMUST00000256155.1 ENSMUSG00000123094 (from geneSymbol) uc332ahi.1 uc332ahi.1 
ENSMUST00000256176.1 Gm57105 ENSMUST00000256176.1 Gm57105 (from geneSymbol) uc332aic.1 uc332aic.1 
ENSMUST00000256178.1 ENSMUSG00000123095 ENSMUST00000256178.1 ENSMUSG00000123095 (from geneSymbol) uc332aie.1 uc332aie.1 
ENSMUST00000256179.1 ENSMUSG00000123096 ENSMUST00000256179.1 ENSMUSG00000123096 (from geneSymbol) uc332aif.1 uc332aif.1 
ENSMUST00000256180.1 ENSMUSG00000123097 ENSMUST00000256180.1 ENSMUSG00000123097 (from geneSymbol) uc332aig.1 uc332aig.1 
ENSMUST00000256181.1 ENSMUSG00000123098 ENSMUST00000256181.1 ENSMUSG00000123098 (from geneSymbol) uc332aih.1 uc332aih.1 
ENSMUST00000256182.1 ENSMUSG00000123099 ENSMUST00000256182.1 ENSMUSG00000123099 (from geneSymbol) uc332aii.1 uc332aii.1 
ENSMUST00000256190.1 ENSMUSG00000123100 ENSMUST00000256190.1 ENSMUSG00000123100 (from geneSymbol) uc332aiq.1 uc332aiq.1 
ENSMUST00000256192.1 ENSMUSG00000123101 ENSMUST00000256192.1 ENSMUSG00000123101 (from geneSymbol) uc332ais.1 uc332ais.1 
ENSMUST00000256195.1 ENSMUSG00000121642 ENSMUST00000256195.1 ENSMUSG00000121642 (from geneSymbol) uc332aiv.1 uc332aiv.1 
ENSMUST00000256200.1 ENSMUSG00000123102 ENSMUST00000256200.1 ENSMUSG00000123102 (from geneSymbol) uc332aja.1 uc332aja.1 
ENSMUST00000256204.1 D830005E20Rik ENSMUST00000256204.1 D830005E20Rik (from geneSymbol) AK085762 uc332aje.1 uc332aje.1 
ENSMUST00000256209.1 ENSMUSG00000123103 ENSMUST00000256209.1 ENSMUSG00000123103 (from geneSymbol) uc332ajj.1 uc332ajj.1 
ENSMUST00000256210.1 ENSMUSG00000123104 ENSMUST00000256210.1 ENSMUSG00000123104 (from geneSymbol) uc332ajk.1 uc332ajk.1 
ENSMUST00000256211.1 ENSMUSG00000123105 ENSMUST00000256211.1 ENSMUSG00000123105 (from geneSymbol) uc332ajl.1 uc332ajl.1 
ENSMUST00000256212.1 ENSMUSG00000123106 ENSMUST00000256212.1 ENSMUSG00000123106 (from geneSymbol) uc332ajm.1 uc332ajm.1 
ENSMUST00000256213.1 ENSMUSG00000123107 ENSMUST00000256213.1 ENSMUSG00000123107 (from geneSymbol) uc332ajn.1 uc332ajn.1 
ENSMUST00000256214.1 ENSMUSG00000123108 ENSMUST00000256214.1 ENSMUSG00000123108 (from geneSymbol) uc332ajo.1 uc332ajo.1 
ENSMUST00000256215.1 ENSMUSG00000123109 ENSMUST00000256215.1 ENSMUSG00000123109 (from geneSymbol) AK007045 uc332ajp.1 uc332ajp.1 
ENSMUST00000256221.1 ENSMUSG00000123110 ENSMUST00000256221.1 ENSMUSG00000123110 (from geneSymbol) uc332ajv.1 uc332ajv.1 
ENSMUST00000256231.1 ENSMUSG00000123111 ENSMUST00000256231.1 ENSMUSG00000123111 (from geneSymbol) uc332akf.1 uc332akf.1 
ENSMUST00000256232.1 4933411E06Rik ENSMUST00000256232.1 4933411E06Rik (from geneSymbol) uc332akg.1 uc332akg.1 
ENSMUST00000256235.1 ENSMUSG00000123112 ENSMUST00000256235.1 ENSMUSG00000123112 (from geneSymbol) uc332aki.1 uc332aki.1 
ENSMUST00000256237.1 ENSMUSG00000123113 ENSMUST00000256237.1 ENSMUSG00000123113 (from geneSymbol) uc332akj.1 uc332akj.1 
ENSMUST00000256239.1 ENSMUSG00000123114 ENSMUST00000256239.1 ENSMUSG00000123114 (from geneSymbol) uc332akl.1 uc332akl.1 
ENSMUST00000256240.1 ENSMUSG00000123115 ENSMUST00000256240.1 ENSMUSG00000123115 (from geneSymbol) uc332akm.1 uc332akm.1 
ENSMUST00000256242.1 ENSMUSG00000123116 ENSMUST00000256242.1 ENSMUSG00000123116 (from geneSymbol) uc332ako.1 uc332ako.1 
ENSMUST00000256245.1 ENSMUSG00000123117 ENSMUST00000256245.1 ENSMUSG00000123117 (from geneSymbol) AK005595 uc332akr.1 uc332akr.1 
ENSMUST00000256246.1 ENSMUSG00000123118 ENSMUST00000256246.1 ENSMUSG00000123118 (from geneSymbol) AK089049 uc332aks.1 uc332aks.1 
ENSMUST00000256247.1 Gm35204 ENSMUST00000256247.1 Gm35204 (from geneSymbol) uc332akt.1 uc332akt.1 
ENSMUST00000256269.1 ENSMUSG00000123120 ENSMUST00000256269.1 ENSMUSG00000123120 (from geneSymbol) uc332alo.1 uc332alo.1 
ENSMUST00000256271.1 ENSMUSG00000123121 ENSMUST00000256271.1 ENSMUSG00000123121 (from geneSymbol) BC150918 uc332alq.1 uc332alq.1 
ENSMUST00000256277.1 ENSMUSG00000123122 ENSMUST00000256277.1 ENSMUSG00000123122 (from geneSymbol) uc332alw.1 uc332alw.1 
ENSMUST00000256285.1 Gm48801 ENSMUST00000256285.1 Gm48801 (from geneSymbol) uc332ame.1 uc332ame.1 
ENSMUST00000256288.1 ENSMUSG00000123123 ENSMUST00000256288.1 ENSMUSG00000123123 (from geneSymbol) uc332amh.1 uc332amh.1 
ENSMUST00000256289.1 ENSMUSG00000123124 ENSMUST00000256289.1 ENSMUSG00000123124 (from geneSymbol) uc332ami.1 uc332ami.1 
ENSMUST00000256290.1 ENSMUSG00000123125 ENSMUST00000256290.1 ENSMUSG00000123125 (from geneSymbol) uc332amj.1 uc332amj.1 
ENSMUST00000256293.1 Gm26511 ENSMUST00000256293.1 Gm26511 (from geneSymbol) AK082154 uc332amm.1 uc332amm.1 
ENSMUST00000256295.1 ENSMUSG00000123126 ENSMUST00000256295.1 ENSMUSG00000123126 (from geneSymbol) uc332amo.1 uc332amo.1 
ENSMUST00000256314.1 ENSMUSG00000123127 ENSMUST00000256314.1 ENSMUSG00000123127 (from geneSymbol) uc332anh.1 uc332anh.1 
ENSMUST00000256325.1 Gm47489 ENSMUST00000256325.1 Gm47489 (from geneSymbol) uc332ans.1 uc332ans.1 
ENSMUST00000256327.1 ENSMUSG00000123128 ENSMUST00000256327.1 ENSMUSG00000123128 (from geneSymbol) uc332anu.1 uc332anu.1 
ENSMUST00000256329.1 4933421O10Rik ENSMUST00000256329.1 4933421O10Rik (from geneSymbol) AK076922 uc332anw.1 uc332anw.1 
ENSMUST00000256340.1 ENSMUSG00000123129 ENSMUST00000256340.1 ENSMUSG00000123129 (from geneSymbol) uc332aoh.1 uc332aoh.1 
ENSMUST00000256341.1 Gm31522 ENSMUST00000256341.1 Gm31522 (from geneSymbol) uc332aoi.1 uc332aoi.1 
ENSMUST00000256370.1 Gm57283 ENSMUST00000256370.1 Gm57283 (from geneSymbol) uc332apl.1 uc332apl.1 
ENSMUST00000256394.1 ENSMUSG00000123130 ENSMUST00000256394.1 ENSMUSG00000123130 (from geneSymbol) uc332aqj.1 uc332aqj.1 
ENSMUST00000256397.1 ENSMUSG00000123131 ENSMUST00000256397.1 ENSMUSG00000123131 (from geneSymbol) uc332aqm.1 uc332aqm.1 
ENSMUST00000256398.1 ENSMUSG00000123132 ENSMUST00000256398.1 ENSMUSG00000123132 (from geneSymbol) uc332aqn.1 uc332aqn.1 
ENSMUST00000256399.1 ENSMUSG00000123133 ENSMUST00000256399.1 ENSMUSG00000123133 (from geneSymbol) uc332aqo.1 uc332aqo.1 
ENSMUST00000256401.1 ENSMUSG00000123134 ENSMUST00000256401.1 ENSMUSG00000123134 (from geneSymbol) uc332aqq.1 uc332aqq.1 
ENSMUST00000256406.1 ENSMUSG00000123135 ENSMUST00000256406.1 ENSMUSG00000123135 (from geneSymbol) uc332aqv.1 uc332aqv.1 
ENSMUST00000256407.1 ENSMUSG00000123136 ENSMUST00000256407.1 ENSMUSG00000123136 (from geneSymbol) uc332aqw.1 uc332aqw.1 
ENSMUST00000256408.1 ENSMUSG00000123137 ENSMUST00000256408.1 ENSMUSG00000123137 (from geneSymbol) uc332aqx.1 uc332aqx.1 
ENSMUST00000256418.1 ENSMUSG00000123138 ENSMUST00000256418.1 ENSMUSG00000123138 (from geneSymbol) uc332arh.1 uc332arh.1 
ENSMUST00000256421.1 ENSMUSG00000123139 ENSMUST00000256421.1 ENSMUSG00000123139 (from geneSymbol) uc332ark.1 uc332ark.1 
ENSMUST00000256432.1 ENSMUSG00000123140 ENSMUST00000256432.1 ENSMUSG00000123140 (from geneSymbol) AK031499 uc332arv.1 uc332arv.1 
ENSMUST00000256435.1 ENSMUSG00000123142 ENSMUST00000256435.1 ENSMUSG00000123142 (from geneSymbol) uc332arw.1 uc332arw.1 
ENSMUST00000256436.1 ENSMUSG00000123143 ENSMUST00000256436.1 ENSMUSG00000123143 (from geneSymbol) uc332arx.1 uc332arx.1 
ENSMUST00000256438.1 ENSMUSG00000123144 ENSMUST00000256438.1 ENSMUSG00000123144 (from geneSymbol) uc332arz.1 uc332arz.1 
ENSMUST00000256439.1 ENSMUSG00000123145 ENSMUST00000256439.1 ENSMUSG00000123145 (from geneSymbol) uc332asa.1 uc332asa.1 
ENSMUST00000256443.1 1700003P14Rik ENSMUST00000256443.1 1700003P14Rik (from geneSymbol) AK005657 uc332ase.1 uc332ase.1 
ENSMUST00000256477.1 ENSMUSG00000123146 ENSMUST00000256477.1 ENSMUSG00000123146 (from geneSymbol) uc332atm.1 uc332atm.1 
ENSMUST00000256479.1 ENSMUSG00000123147 ENSMUST00000256479.1 ENSMUSG00000123147 (from geneSymbol) uc332ato.1 uc332ato.1 
ENSMUST00000256482.1 ENSMUSG00000123148 ENSMUST00000256482.1 ENSMUSG00000123148 (from geneSymbol) uc332atr.1 uc332atr.1 
ENSMUST00000256486.1 ENSMUSG00000123149 ENSMUST00000256486.1 ENSMUSG00000123149 (from geneSymbol) uc332atu.1 uc332atu.1 
ENSMUST00000256495.1 ENSMUSG00000123150 ENSMUST00000256495.1 ENSMUSG00000123150 (from geneSymbol) uc332aud.1 uc332aud.1 
ENSMUST00000256502.1 ENSMUSG00000123151 ENSMUST00000256502.1 ENSMUSG00000123151 (from geneSymbol) uc332auk.1 uc332auk.1 
ENSMUST00000256504.1 Gm15997 ENSMUST00000256504.1 Gm15997 (from geneSymbol) AK043895 uc332aum.1 uc332aum.1 
ENSMUST00000256512.1 ENSMUSG00000123152 ENSMUST00000256512.1 ENSMUSG00000123152 (from geneSymbol) uc332auu.1 uc332auu.1 
ENSMUST00000256513.1 ENSMUSG00000123153 ENSMUST00000256513.1 ENSMUSG00000123153 (from geneSymbol) uc332auv.1 uc332auv.1 
ENSMUST00000256514.1 ENSMUSG00000123154 ENSMUST00000256514.1 ENSMUSG00000123154 (from geneSymbol) uc332auw.1 uc332auw.1 
ENSMUST00000256516.1 Gm36246 ENSMUST00000256516.1 Gm36246 (from geneSymbol) uc332auy.1 uc332auy.1 
ENSMUST00000256537.1 ENSMUSG00000123155 ENSMUST00000256537.1 ENSMUSG00000123155 (from geneSymbol) uc332avt.1 uc332avt.1 
ENSMUST00000256538.1 ENSMUSG00000123156 ENSMUST00000256538.1 ENSMUSG00000123156 (from geneSymbol) uc332avu.1 uc332avu.1 
ENSMUST00000256539.1 1700105G05Rik ENSMUST00000256539.1 1700105G05Rik (from geneSymbol) AK007126 uc332avv.1 uc332avv.1 
ENSMUST00000256543.1 Gm34004 ENSMUST00000256543.1 Gm34004 (from geneSymbol) uc332avz.1 uc332avz.1 
ENSMUST00000256557.1 ENSMUSG00000123157 ENSMUST00000256557.1 ENSMUSG00000123157 (from geneSymbol) uc332awn.1 uc332awn.1 
ENSMUST00000256558.1 ENSMUSG00000123158 ENSMUST00000256558.1 ENSMUSG00000123158 (from geneSymbol) uc332awo.1 uc332awo.1 
ENSMUST00000256560.1 ENSMUSG00000123159 ENSMUST00000256560.1 ENSMUSG00000123159 (from geneSymbol) uc332awq.1 uc332awq.1 
ENSMUST00000256561.1 ENSMUSG00000123160 ENSMUST00000256561.1 ENSMUSG00000123160 (from geneSymbol) uc332awr.1 uc332awr.1 
ENSMUST00000256567.1 ENSMUSG00000123162 ENSMUST00000256567.1 ENSMUSG00000123162 (from geneSymbol) uc332aws.1 uc332aws.1 
ENSMUST00000256569.1 ENSMUSG00000123163 ENSMUST00000256569.1 ENSMUSG00000123163 (from geneSymbol) uc332awu.1 uc332awu.1 
ENSMUST00000256575.1 ENSMUSG00000123164 ENSMUST00000256575.1 ENSMUSG00000123164 (from geneSymbol) uc332axa.1 uc332axa.1 
ENSMUST00000256577.1 ENSMUSG00000123165 ENSMUST00000256577.1 ENSMUSG00000123165 (from geneSymbol) uc332axc.1 uc332axc.1 
ENSMUST00000256587.1 Gm11419 ENSMUST00000256587.1 Gm11419 (from geneSymbol) uc332axm.1 uc332axm.1 
ENSMUST00000256624.1 ENSMUSG00000123166 ENSMUST00000256624.1 ENSMUSG00000123166 (from geneSymbol) uc332ayx.1 uc332ayx.1 
ENSMUST00000256626.1 ENSMUSG00000123167 ENSMUST00000256626.1 ENSMUSG00000123167 (from geneSymbol) uc332ayz.1 uc332ayz.1 
ENSMUST00000256629.1 Gm27246 ENSMUST00000256629.1 predicted gene 27246 (from RefSeq NR_168261.1) NR_168261 uc332azc.1 uc332azc.1 
ENSMUST00000256631.1 ENSMUSG00000123168 ENSMUST00000256631.1 ENSMUSG00000123168 (from geneSymbol) uc332aze.1 uc332aze.1 
ENSMUST00000256646.1 ENSMUSG00000123169 ENSMUST00000256646.1 ENSMUSG00000123169 (from geneSymbol) uc332azt.1 uc332azt.1 
ENSMUST00000256681.1 ENSMUSG00000123170 ENSMUST00000256681.1 ENSMUSG00000123170 (from geneSymbol) uc332bbc.1 uc332bbc.1 
ENSMUST00000256682.1 ENSMUSG00000123171 ENSMUST00000256682.1 ENSMUSG00000123171 (from geneSymbol) uc332bbd.1 uc332bbd.1 
ENSMUST00000256685.1 ENSMUSG00000123172 ENSMUST00000256685.1 ENSMUSG00000123172 (from geneSymbol) uc332bbg.1 uc332bbg.1 
ENSMUST00000256691.1 ENSMUSG00000123173 ENSMUST00000256691.1 ENSMUSG00000123173 (from geneSymbol) uc332bbm.1 uc332bbm.1 
ENSMUST00000256692.1 ENSMUSG00000123174 ENSMUST00000256692.1 ENSMUSG00000123174 (from geneSymbol) uc332bbn.1 uc332bbn.1 
ENSMUST00000256694.1 ENSMUSG00000123175 ENSMUST00000256694.1 ENSMUSG00000123175 (from geneSymbol) uc332bbp.1 uc332bbp.1 
ENSMUST00000256697.1 ENSMUSG00000123176 ENSMUST00000256697.1 ENSMUSG00000123176 (from geneSymbol) uc332bbs.1 uc332bbs.1 
ENSMUST00000256699.1 7330404K18Rik ENSMUST00000256699.1 7330404K18Rik (from geneSymbol) AK020178 uc332bbu.1 uc332bbu.1 
ENSMUST00000256700.1 ENSMUSG00000123177 ENSMUST00000256700.1 ENSMUSG00000123177 (from geneSymbol) uc332bbv.1 uc332bbv.1 
ENSMUST00000256701.1 ENSMUSG00000123178 ENSMUST00000256701.1 ENSMUSG00000123178 (from geneSymbol) uc332bbw.1 uc332bbw.1 
ENSMUST00000256703.1 G630093K05Rik ENSMUST00000256703.1 G630093K05Rik (from geneSymbol) AK144546 uc332bbx.1 uc332bbx.1 
ENSMUST00000256713.1 4930529K09Rik ENSMUST00000256713.1 4930529K09Rik (from geneSymbol) AK015937 uc332bch.1 uc332bch.1 
ENSMUST00000256786.1 ENSMUSG00000123180 ENSMUST00000256786.1 ENSMUSG00000123180 (from geneSymbol) uc332bfc.1 uc332bfc.1 
ENSMUST00000256790.1 ENSMUSG00000123181 ENSMUST00000256790.1 ENSMUSG00000123181 (from geneSymbol) AK039603 uc332bff.1 uc332bff.1 
ENSMUST00000256791.1 ENSMUSG00000123182 ENSMUST00000256791.1 ENSMUSG00000123182 (from geneSymbol) uc332bfg.1 uc332bfg.1 
ENSMUST00000256792.1 Gm15540 ENSMUST00000256792.1 Gm15540 (from geneSymbol) uc332bfh.1 uc332bfh.1 
ENSMUST00000256795.1 ENSMUSG00000123183 ENSMUST00000256795.1 ENSMUSG00000123183 (from geneSymbol) uc332bfk.1 uc332bfk.1 
ENSMUST00000256796.1 ENSMUSG00000123184 ENSMUST00000256796.1 ENSMUSG00000123184 (from geneSymbol) uc332bfl.1 uc332bfl.1 
ENSMUST00000256797.1 ENSMUSG00000123185 ENSMUST00000256797.1 ENSMUSG00000123185 (from geneSymbol) uc332bfm.1 uc332bfm.1 
ENSMUST00000256801.1 Gm56671 ENSMUST00000256801.1 Gm56671 (from geneSymbol) uc332bfq.1 uc332bfq.1 
ENSMUST00000256807.1 ENSMUSG00000123186 ENSMUST00000256807.1 ENSMUSG00000123186 (from geneSymbol) uc332bfw.1 uc332bfw.1 
ENSMUST00000256808.1 ENSMUSG00000123187 ENSMUST00000256808.1 ENSMUSG00000123187 (from geneSymbol) uc332bfx.1 uc332bfx.1 
ENSMUST00000256812.1 ENSMUSG00000123188 ENSMUST00000256812.1 ENSMUSG00000123188 (from geneSymbol) uc332bgb.1 uc332bgb.1 
ENSMUST00000256815.1 ENSMUSG00000123189 ENSMUST00000256815.1 ENSMUSG00000123189 (from geneSymbol) uc332bge.1 uc332bge.1 
ENSMUST00000256827.1 ENSMUSG00000123190 ENSMUST00000256827.1 ENSMUSG00000123190 (from geneSymbol) uc332bgq.1 uc332bgq.1 
ENSMUST00000256829.1 C430002N11Rik ENSMUST00000256829.1 C430002N11Rik (from geneSymbol) AK049386 uc332bgs.1 uc332bgs.1 
ENSMUST00000256840.1 ENSMUSG00000123191 ENSMUST00000256840.1 ENSMUSG00000123191 (from geneSymbol) uc332bhd.1 uc332bhd.1 
ENSMUST00000256841.1 ENSMUSG00000123192 ENSMUST00000256841.1 ENSMUSG00000123192 (from geneSymbol) uc332bhe.1 uc332bhe.1 
ENSMUST00000256846.1 ENSMUSG00000123193 ENSMUST00000256846.1 ENSMUSG00000123193 (from geneSymbol) uc332bhj.1 uc332bhj.1 
ENSMUST00000256847.1 ENSMUSG00000123194 ENSMUST00000256847.1 ENSMUSG00000123194 (from geneSymbol) uc332bhk.1 uc332bhk.1 
ENSMUST00000256855.1 ENSMUSG00000123195 ENSMUST00000256855.1 ENSMUSG00000123195 (from geneSymbol) uc332bhs.1 uc332bhs.1 
ENSMUST00000256858.1 B230112J18Rik ENSMUST00000256858.1 B230112J18Rik (from geneSymbol) AK020970 uc332bhv.1 uc332bhv.1 
ENSMUST00000256903.1 ENSMUSG00000123196 ENSMUST00000256903.1 ENSMUSG00000123196 (from geneSymbol) uc332bjo.1 uc332bjo.1 
ENSMUST00000256906.1 ENSMUSG00000123197 ENSMUST00000256906.1 ENSMUSG00000123197 (from geneSymbol) uc332bjr.1 uc332bjr.1 
ENSMUST00000256913.1 ENSMUSG00000123198 ENSMUST00000256913.1 ENSMUSG00000123198 (from geneSymbol) uc332bjy.1 uc332bjy.1 
ENSMUST00000256915.1 ENSMUSG00000123199 ENSMUST00000256915.1 ENSMUSG00000123199 (from geneSymbol) uc332bka.1 uc332bka.1 
ENSMUST00000256952.1 ENSMUSG00000123200 ENSMUST00000256952.1 ENSMUSG00000123200 (from geneSymbol) uc332bll.1 uc332bll.1 
ENSMUST00000256957.1 Gm30726 ENSMUST00000256957.1 Gm30726 (from geneSymbol) uc332blq.1 uc332blq.1 
ENSMUST00000256961.1 ENSMUSG00000123201 ENSMUST00000256961.1 ENSMUSG00000123201 (from geneSymbol) uc332blu.1 uc332blu.1 
ENSMUST00000256963.1 ENSMUSG00000123202 ENSMUST00000256963.1 ENSMUSG00000123202 (from geneSymbol) uc332blw.1 uc332blw.1 
ENSMUST00000256965.1 Gm57162 ENSMUST00000256965.1 Gm57162 (from geneSymbol) uc332bly.1 uc332bly.1 
ENSMUST00000256971.1 ENSMUSG00000123203 ENSMUST00000256971.1 ENSMUSG00000123203 (from geneSymbol) uc332bme.1 uc332bme.1 
ENSMUST00000256974.1 ENSMUSG00000123205 ENSMUST00000256974.1 ENSMUSG00000123205 (from geneSymbol) uc332bmg.1 uc332bmg.1 
ENSMUST00000256981.1 ENSMUSG00000123206 ENSMUST00000256981.1 ENSMUSG00000123206 (from geneSymbol) uc332bmn.1 uc332bmn.1 
ENSMUST00000256982.1 ENSMUSG00000123207 ENSMUST00000256982.1 ENSMUSG00000123207 (from geneSymbol) uc332bmo.1 uc332bmo.1 
ENSMUST00000256985.1 ENSMUSG00000123208 ENSMUST00000256985.1 ENSMUSG00000123208 (from geneSymbol) uc332bmr.1 uc332bmr.1 
ENSMUST00000256986.1 ENSMUSG00000123209 ENSMUST00000256986.1 ENSMUSG00000123209 (from geneSymbol) uc332bms.1 uc332bms.1 
ENSMUST00000256987.1 Gm10244 ENSMUST00000256987.1 Gm10244 (from geneSymbol) AB106871 uc332bmt.1 uc332bmt.1 
ENSMUST00000256989.1 ENSMUSG00000123210 ENSMUST00000256989.1 ENSMUSG00000123210 (from geneSymbol) uc332bmv.1 uc332bmv.1 
ENSMUST00000256991.1 ENSMUSG00000123211 ENSMUST00000256991.1 ENSMUSG00000123211 (from geneSymbol) uc332bmx.1 uc332bmx.1 
ENSMUST00000256992.1 ENSMUSG00000123212 ENSMUST00000256992.1 ENSMUSG00000123212 (from geneSymbol) uc332bmy.1 uc332bmy.1 
ENSMUST00000256995.1 ENSMUSG00000123213 ENSMUST00000256995.1 ENSMUSG00000123213 (from geneSymbol) uc332bnb.1 uc332bnb.1 
ENSMUST00000256996.1 ENSMUSG00000123214 ENSMUST00000256996.1 ENSMUSG00000123214 (from geneSymbol) uc332bnc.1 uc332bnc.1 
ENSMUST00000257005.1 ENSMUSG00000123215 ENSMUST00000257005.1 ENSMUSG00000123215 (from geneSymbol) uc332bnl.1 uc332bnl.1 
ENSMUST00000257007.1 ENSMUSG00000123216 ENSMUST00000257007.1 ENSMUSG00000123216 (from geneSymbol) uc332bnn.1 uc332bnn.1 
ENSMUST00000257011.1 ENSMUSG00000123217 ENSMUST00000257011.1 ENSMUSG00000123217 (from geneSymbol) uc332bnr.1 uc332bnr.1 
ENSMUST00000257015.1 ENSMUSG00000123218 ENSMUST00000257015.1 ENSMUSG00000123218 (from geneSymbol) uc332bnv.1 uc332bnv.1 
ENSMUST00000257024.1 Gm57168 ENSMUST00000257024.1 Gm57168 (from geneSymbol) uc332boe.1 uc332boe.1 
ENSMUST00000257026.1 ENSMUSG00000123219 ENSMUST00000257026.1 ENSMUSG00000123219 (from geneSymbol) uc332bog.1 uc332bog.1 
ENSMUST00000257027.1 ENSMUSG00000123220 ENSMUST00000257027.1 ENSMUSG00000123220 (from geneSymbol) uc332boh.1 uc332boh.1 
ENSMUST00000257029.1 ENSMUSG00000123221 ENSMUST00000257029.1 ENSMUSG00000123221 (from geneSymbol) uc332boj.1 uc332boj.1 
ENSMUST00000257048.1 ENSMUSG00000123222 ENSMUST00000257048.1 ENSMUSG00000123222 (from geneSymbol) uc332bpc.1 uc332bpc.1 
ENSMUST00000257050.1 ENSMUSG00000123223 ENSMUST00000257050.1 ENSMUSG00000123223 (from geneSymbol) uc332bpe.1 uc332bpe.1 
ENSMUST00000257051.1 ENSMUSG00000123224 ENSMUST00000257051.1 ENSMUSG00000123224 (from geneSymbol) uc332bpf.1 uc332bpf.1 
ENSMUST00000257052.1 ENSMUSG00000123225 ENSMUST00000257052.1 ENSMUSG00000123225 (from geneSymbol) uc332bpg.1 uc332bpg.1 
ENSMUST00000257055.1 ENSMUSG00000123226 ENSMUST00000257055.1 ENSMUSG00000123226 (from geneSymbol) uc332bpj.1 uc332bpj.1 
ENSMUST00000257064.1 4921531P14Rik ENSMUST00000257064.1 4921531P14Rik (from geneSymbol) AK007141 uc332bps.1 uc332bps.1 
ENSMUST00000257087.1 ENSMUSG00000123227 ENSMUST00000257087.1 ENSMUSG00000123227 (from geneSymbol) LF203523 uc332bqp.1 uc332bqp.1 
ENSMUST00000257094.1 ENSMUSG00000123228 ENSMUST00000257094.1 ENSMUSG00000123228 (from geneSymbol) uc332bqw.1 uc332bqw.1 
ENSMUST00000257097.1 ENSMUSG00000123229 ENSMUST00000257097.1 ENSMUSG00000123229 (from geneSymbol) uc332bqz.1 uc332bqz.1 
ENSMUST00000257099.1 ENSMUSG00000123230 ENSMUST00000257099.1 ENSMUSG00000123230 (from geneSymbol) uc332brb.1 uc332brb.1 
ENSMUST00000257100.1 ENSMUSG00000123231 ENSMUST00000257100.1 ENSMUSG00000123231 (from geneSymbol) AB343192 uc332brc.1 uc332brc.1 
ENSMUST00000257101.1 ENSMUSG00000123232 ENSMUST00000257101.1 ENSMUSG00000123232 (from geneSymbol) uc332brd.1 uc332brd.1 
ENSMUST00000257102.1 ENSMUSG00000123233 ENSMUST00000257102.1 ENSMUSG00000123233 (from geneSymbol) uc332bre.1 uc332bre.1 
ENSMUST00000257108.1 ENSMUSG00000123234 ENSMUST00000257108.1 ENSMUSG00000123234 (from geneSymbol) uc332brk.1 uc332brk.1 
ENSMUST00000257128.1 ENSMUSG00000123235 ENSMUST00000257128.1 ENSMUSG00000123235 (from geneSymbol) uc332bse.1 uc332bse.1 
ENSMUST00000257133.1 ENSMUSG00000123236 ENSMUST00000257133.1 ENSMUSG00000123236 (from geneSymbol) uc332bsj.1 uc332bsj.1 
ENSMUST00000257138.1 ENSMUSG00000123237 ENSMUST00000257138.1 ENSMUSG00000123237 (from geneSymbol) uc332bso.1 uc332bso.1 
ENSMUST00000257140.1 ENSMUSG00000123238 ENSMUST00000257140.1 ENSMUSG00000123238 (from geneSymbol) uc332bsq.1 uc332bsq.1 
ENSMUST00000257154.1 ENSMUSG00000121825 ENSMUST00000257154.1 ENSMUSG00000121825 (from geneSymbol) uc332bte.1 uc332bte.1 
ENSMUST00000257158.1 ENSMUSG00000123240 ENSMUST00000257158.1 ENSMUSG00000123240 (from geneSymbol) uc332bth.1 uc332bth.1 
ENSMUST00000257159.1 ENSMUSG00000123241 ENSMUST00000257159.1 ENSMUSG00000123241 (from geneSymbol) uc332bti.1 uc332bti.1 
ENSMUST00000257161.1 ENSMUSG00000123242 ENSMUST00000257161.1 ENSMUSG00000123242 (from geneSymbol) uc332btk.1 uc332btk.1 
ENSMUST00000257163.1 ENSMUSG00000123243 ENSMUST00000257163.1 ENSMUSG00000123243 (from geneSymbol) uc332btm.1 uc332btm.1 
ENSMUST00000257164.1 ENSMUSG00000123244 ENSMUST00000257164.1 ENSMUSG00000123244 (from geneSymbol) uc332btn.1 uc332btn.1 
ENSMUST00000257165.1 ENSMUSG00000123245 ENSMUST00000257165.1 ENSMUSG00000123245 (from geneSymbol) uc332bto.1 uc332bto.1 
ENSMUST00000257166.1 ENSMUSG00000123246 ENSMUST00000257166.1 ENSMUSG00000123246 (from geneSymbol) uc332btp.1 uc332btp.1 
ENSMUST00000257167.1 ENSMUSG00000123247 ENSMUST00000257167.1 ENSMUSG00000123247 (from geneSymbol) uc332btq.1 uc332btq.1 
ENSMUST00000257168.1 ENSMUSG00000123248 ENSMUST00000257168.1 ENSMUSG00000123248 (from geneSymbol) uc332btr.1 uc332btr.1 
ENSMUST00000257170.1 ENSMUSG00000123249 ENSMUST00000257170.1 ENSMUSG00000123249 (from geneSymbol) uc332btt.1 uc332btt.1 
ENSMUST00000257171.1 ENSMUSG00000123250 ENSMUST00000257171.1 ENSMUSG00000123250 (from geneSymbol) uc332btu.1 uc332btu.1 
ENSMUST00000257173.1 ENSMUSG00000123251 ENSMUST00000257173.1 ENSMUSG00000123251 (from geneSymbol) uc332btw.1 uc332btw.1 
ENSMUST00000257179.1 ENSMUSG00000123252 ENSMUST00000257179.1 ENSMUSG00000123252 (from geneSymbol) uc332buc.1 uc332buc.1 
ENSMUST00000257180.1 ENSMUSG00000123253 ENSMUST00000257180.1 ENSMUSG00000123253 (from geneSymbol) uc332bud.1 uc332bud.1 
ENSMUST00000257182.1 ENSMUSG00000123254 ENSMUST00000257182.1 ENSMUSG00000123254 (from geneSymbol) uc332buf.1 uc332buf.1 
ENSMUST00000257183.1 ENSMUSG00000123255 ENSMUST00000257183.1 ENSMUSG00000123255 (from geneSymbol) uc332bug.1 uc332bug.1 
ENSMUST00000257184.1 Gm32960 ENSMUST00000257184.1 Gm32960 (from geneSymbol) AK085625 uc332buh.1 uc332buh.1 
ENSMUST00000257199.1 ENSMUSG00000123256 ENSMUST00000257199.1 ENSMUSG00000123256 (from geneSymbol) uc332buw.1 uc332buw.1 
ENSMUST00000257203.1 ENSMUSG00000123257 ENSMUST00000257203.1 ENSMUSG00000123257 (from geneSymbol) uc332bva.1 uc332bva.1 
ENSMUST00000257206.1 ENSMUSG00000123258 ENSMUST00000257206.1 ENSMUSG00000123258 (from geneSymbol) uc332bvd.1 uc332bvd.1 
ENSMUST00000257212.1 Gm4251 ENSMUST00000257212.1 Gm4251 (from geneSymbol) AK076894 uc332bvj.1 uc332bvj.1 
ENSMUST00000257220.1 ENSMUSG00000123259 ENSMUST00000257220.1 ENSMUSG00000123259 (from geneSymbol) uc332bvr.1 uc332bvr.1 
ENSMUST00000257221.1 ENSMUSG00000123260 ENSMUST00000257221.1 ENSMUSG00000123260 (from geneSymbol) uc332bvs.1 uc332bvs.1 
ENSMUST00000257223.1 ENSMUSG00000123261 ENSMUST00000257223.1 ENSMUSG00000123261 (from geneSymbol) uc332bvu.1 uc332bvu.1 
ENSMUST00000257228.1 Gm50147 ENSMUST00000257228.1 Gm50147 (from geneSymbol) uc332bvz.1 uc332bvz.1 
ENSMUST00000257233.1 1700016P04Rik ENSMUST00000257233.1 1700016P04Rik (from geneSymbol) AK006052 uc332bwe.1 uc332bwe.1 
ENSMUST00000257247.1 Hdnr ENSMUST00000257247.1 Hdnr (from geneSymbol) AK017203 uc332bws.1 uc332bws.1 
ENSMUST00000257384.1 ENSMUSG00000123262 ENSMUST00000257384.1 ENSMUSG00000123262 (from geneSymbol) uc332cbx.1 uc332cbx.1 
ENSMUST00000257387.1 ENSMUSG00000123263 ENSMUST00000257387.1 ENSMUSG00000123263 (from geneSymbol) uc332cca.1 uc332cca.1 
ENSMUST00000257388.1 Gm43614 ENSMUST00000257388.1 Gm43614 (from geneSymbol) uc332ccb.1 uc332ccb.1 
ENSMUST00000257389.1 ENSMUSG00000123264 ENSMUST00000257389.1 ENSMUSG00000123264 (from geneSymbol) uc332ccc.1 uc332ccc.1 
ENSMUST00000257393.1 ENSMUSG00000123265 ENSMUST00000257393.1 ENSMUSG00000123265 (from geneSymbol) uc332ccg.1 uc332ccg.1 
ENSMUST00000257394.1 ENSMUSG00000123266 ENSMUST00000257394.1 ENSMUSG00000123266 (from geneSymbol) uc332cch.1 uc332cch.1 
ENSMUST00000257399.1 ENSMUSG00000123267 ENSMUST00000257399.1 ENSMUSG00000123267 (from geneSymbol) uc332ccm.1 uc332ccm.1 
ENSMUST00000257402.1 ENSMUSG00000123268 ENSMUST00000257402.1 ENSMUSG00000123268 (from geneSymbol) uc332ccp.1 uc332ccp.1 
ENSMUST00000257405.1 ENSMUSG00000123269 ENSMUST00000257405.1 ENSMUSG00000123269 (from geneSymbol) uc332ccs.1 uc332ccs.1 
ENSMUST00000257406.1 ENSMUSG00000123270 ENSMUST00000257406.1 ENSMUSG00000123270 (from geneSymbol) uc332cct.1 uc332cct.1 
ENSMUST00000257407.1 4930500F04Rik ENSMUST00000257407.1 4930500F04Rik (from geneSymbol) AK016439 uc332ccu.1 uc332ccu.1 
ENSMUST00000257410.1 Gm36241 ENSMUST00000257410.1 Gm36241 (from geneSymbol) uc332ccx.1 uc332ccx.1 
ENSMUST00000257413.1 ENSMUSG00000123271 ENSMUST00000257413.1 ENSMUSG00000123271 (from geneSymbol) uc332cda.1 uc332cda.1 
ENSMUST00000257416.1 ENSMUSG00000123272 ENSMUST00000257416.1 ENSMUSG00000123272 (from geneSymbol) uc332cdd.1 uc332cdd.1 
ENSMUST00000257417.1 ENSMUSG00000123273 ENSMUST00000257417.1 ENSMUSG00000123273 (from geneSymbol) uc332cde.1 uc332cde.1 
ENSMUST00000257418.1 ENSMUSG00000123274 ENSMUST00000257418.1 ENSMUSG00000123274 (from geneSymbol) uc332cdf.1 uc332cdf.1 
ENSMUST00000257419.1 ENSMUSG00000123275 ENSMUST00000257419.1 ENSMUSG00000123275 (from geneSymbol) uc332cdg.1 uc332cdg.1 
ENSMUST00000257431.1 ENSMUSG00000123276 ENSMUST00000257431.1 ENSMUSG00000123276 (from geneSymbol) uc332cds.1 uc332cds.1 
ENSMUST00000257432.1 ENSMUSG00000123277 ENSMUST00000257432.1 ENSMUSG00000123277 (from geneSymbol) uc332cdt.1 uc332cdt.1 
ENSMUST00000257434.1 ENSMUSG00000123278 ENSMUST00000257434.1 ENSMUSG00000123278 (from geneSymbol) uc332cdv.1 uc332cdv.1 
ENSMUST00000257439.1 Gm48770 ENSMUST00000257439.1 Gm48770 (from geneSymbol) uc332cea.1 uc332cea.1 
ENSMUST00000257440.1 ENSMUSG00000123279 ENSMUST00000257440.1 ENSMUSG00000123279 (from geneSymbol) uc332ceb.1 uc332ceb.1 
ENSMUST00000257441.1 Gm31774 ENSMUST00000257441.1 Gm31774 (from geneSymbol) AK143772 uc332cec.1 uc332cec.1 
ENSMUST00000257442.1 ENSMUSG00000123280 ENSMUST00000257442.1 ENSMUSG00000123280 (from geneSymbol) uc332ced.1 uc332ced.1 
ENSMUST00000257449.1 ENSMUSG00000123281 ENSMUST00000257449.1 ENSMUSG00000123281 (from geneSymbol) uc332cek.1 uc332cek.1 
ENSMUST00000257451.1 ENSMUSG00000123282 ENSMUST00000257451.1 ENSMUSG00000123282 (from geneSymbol) uc332cem.1 uc332cem.1 
ENSMUST00000257454.1 ENSMUSG00000123283 ENSMUST00000257454.1 ENSMUSG00000123283 (from geneSymbol) uc332cep.1 uc332cep.1 
ENSMUST00000257455.1 ENSMUSG00000123284 ENSMUST00000257455.1 ENSMUSG00000123284 (from geneSymbol) uc332ceq.1 uc332ceq.1 
ENSMUST00000257456.1 ENSMUSG00000123285 ENSMUST00000257456.1 ENSMUSG00000123285 (from geneSymbol) uc332cer.1 uc332cer.1 
ENSMUST00000257459.1 ENSMUSG00000123286 ENSMUST00000257459.1 ENSMUSG00000123286 (from geneSymbol) uc332ceu.1 uc332ceu.1 
ENSMUST00000257462.1 ENSMUSG00000123287 ENSMUST00000257462.1 ENSMUSG00000123287 (from geneSymbol) AY746431 uc332cex.1 uc332cex.1 
ENSMUST00000257465.1 ENSMUSG00000123288 ENSMUST00000257465.1 ENSMUSG00000123288 (from geneSymbol) uc332cfa.1 uc332cfa.1 
ENSMUST00000257466.1 ENSMUSG00000123289 ENSMUST00000257466.1 ENSMUSG00000123289 (from geneSymbol) uc332cfb.1 uc332cfb.1 
ENSMUST00000257467.1 ENSMUSG00000123290 ENSMUST00000257467.1 ENSMUSG00000123290 (from geneSymbol) uc332cfc.1 uc332cfc.1 
ENSMUST00000257469.1 Gm15879 ENSMUST00000257469.1 Gm15879 (from geneSymbol) uc332cfe.1 uc332cfe.1 
ENSMUST00000257473.1 Arf4os ENSMUST00000257473.1 Arf4os (from geneSymbol) AK076950 uc332cfi.1 uc332cfi.1 
ENSMUST00000257476.1 ENSMUSG00000123291 ENSMUST00000257476.1 ENSMUSG00000123291 (from geneSymbol) uc332cfl.1 uc332cfl.1 
ENSMUST00000257478.1 Gm56834 ENSMUST00000257478.1 Gm56834 (from geneSymbol) uc332cfn.1 uc332cfn.1 
ENSMUST00000257484.1 ENSMUSG00000123292 ENSMUST00000257484.1 ENSMUSG00000123292 (from geneSymbol) uc332cft.1 uc332cft.1 
ENSMUST00000257489.1 ENSMUSG00000123293 ENSMUST00000257489.1 ENSMUSG00000123293 (from geneSymbol) uc332cfy.1 uc332cfy.1 
ENSMUST00000257493.1 Gm29200 ENSMUST00000257493.1 Gm29200 (from geneSymbol) AK020362 uc332cgc.1 uc332cgc.1 
ENSMUST00000257497.1 Gm36278 ENSMUST00000257497.1 Gm36278 (from geneSymbol) uc332cgg.1 uc332cgg.1 
ENSMUST00000257500.1 ENSMUSG00000123294 ENSMUST00000257500.1 ENSMUSG00000123294 (from geneSymbol) uc332cgj.1 uc332cgj.1 
ENSMUST00000257502.1 ENSMUSG00000123295 ENSMUST00000257502.1 ENSMUSG00000123295 (from geneSymbol) uc332cgl.1 uc332cgl.1 
ENSMUST00000257504.1 ENSMUSG00000123296 ENSMUST00000257504.1 ENSMUSG00000123296 (from geneSymbol) uc332cgn.1 uc332cgn.1 
ENSMUST00000257505.1 ENSMUSG00000123297 ENSMUST00000257505.1 ENSMUSG00000123297 (from geneSymbol) uc332cgo.1 uc332cgo.1 
ENSMUST00000257506.1 ENSMUSG00000123298 ENSMUST00000257506.1 ENSMUSG00000123298 (from geneSymbol) uc332cgp.1 uc332cgp.1 
ENSMUST00000257507.1 ENSMUSG00000123299 ENSMUST00000257507.1 ENSMUSG00000123299 (from geneSymbol) uc332cgq.1 uc332cgq.1 
ENSMUST00000257508.1 ENSMUSG00000123300 ENSMUST00000257508.1 ENSMUSG00000123300 (from geneSymbol) uc332cgr.1 uc332cgr.1 
ENSMUST00000257514.1 ENSMUSG00000123301 ENSMUST00000257514.1 ENSMUSG00000123301 (from geneSymbol) uc332cgx.1 uc332cgx.1 
ENSMUST00000257515.1 4930557J02Rik ENSMUST00000257515.1 4930557J02Rik (from geneSymbol) AK016164 uc332cgy.1 uc332cgy.1 
ENSMUST00000257517.1 ENSMUSG00000123302 ENSMUST00000257517.1 ENSMUSG00000123302 (from geneSymbol) uc332cha.1 uc332cha.1 
ENSMUST00000257518.1 ENSMUSG00000123303 ENSMUST00000257518.1 ENSMUSG00000123303 (from geneSymbol) uc332chb.1 uc332chb.1 
ENSMUST00000257519.1 ENSMUSG00000123304 ENSMUST00000257519.1 ENSMUSG00000123304 (from geneSymbol) uc332chc.1 uc332chc.1 
ENSMUST00000257521.1 ENSMUSG00000123305 ENSMUST00000257521.1 ENSMUSG00000123305 (from geneSymbol) uc332che.1 uc332che.1 
ENSMUST00000257522.1 ENSMUSG00000123306 ENSMUST00000257522.1 ENSMUSG00000123306 (from geneSymbol) uc332chf.1 uc332chf.1 
ENSMUST00000257526.1 ENSMUSG00000123307 ENSMUST00000257526.1 ENSMUSG00000123307 (from geneSymbol) uc332chj.1 uc332chj.1 
ENSMUST00000257529.1 ENSMUSG00000123308 ENSMUST00000257529.1 ENSMUSG00000123308 (from geneSymbol) uc332chm.1 uc332chm.1 
ENSMUST00000257530.1 ENSMUSG00000123309 ENSMUST00000257530.1 ENSMUSG00000123309 (from geneSymbol) uc332chn.1 uc332chn.1 
ENSMUST00000257543.1 2500002B13Rik ENSMUST00000257543.1 2500002B13Rik (from geneSymbol) AK141659 uc332cia.1 uc332cia.1 
ENSMUST00000257625.1 ENSMUSG00000123310 ENSMUST00000257625.1 ENSMUSG00000123310 (from geneSymbol) uc332cld.1 uc332cld.1 
ENSMUST00000257626.1 ENSMUSG00000123311 ENSMUST00000257626.1 ENSMUSG00000123311 (from geneSymbol) uc332cle.1 uc332cle.1 
ENSMUST00000257634.1 ENSMUSG00000123312 ENSMUST00000257634.1 ENSMUSG00000123312 (from geneSymbol) uc332clm.1 uc332clm.1 
ENSMUST00000257636.1 ENSMUSG00000123313 ENSMUST00000257636.1 ENSMUSG00000123313 (from geneSymbol) uc332clo.1 uc332clo.1 
ENSMUST00000257640.1 ENSMUSG00000123314 ENSMUST00000257640.1 ENSMUSG00000123314 (from geneSymbol) uc332cls.1 uc332cls.1 
ENSMUST00000257642.1 ENSMUSG00000123315 ENSMUST00000257642.1 ENSMUSG00000123315 (from geneSymbol) uc332clu.1 uc332clu.1 
ENSMUST00000257643.1 ENSMUSG00000123316 ENSMUST00000257643.1 ENSMUSG00000123316 (from geneSymbol) uc332clv.1 uc332clv.1 
ENSMUST00000257644.1 ENSMUSG00000123317 ENSMUST00000257644.1 ENSMUSG00000123317 (from geneSymbol) uc332clw.1 uc332clw.1 
ENSMUST00000257649.1 ENSMUSG00000123318 ENSMUST00000257649.1 ENSMUSG00000123318 (from geneSymbol) uc332cmb.1 uc332cmb.1 
ENSMUST00000257651.1 ENSMUSG00000123319 ENSMUST00000257651.1 ENSMUSG00000123319 (from geneSymbol) uc332cmd.1 uc332cmd.1 
ENSMUST00000257652.1 4930570E03Rik ENSMUST00000257652.1 4930570E03Rik (from geneSymbol) AK019797 uc332cme.1 uc332cme.1 
ENSMUST00000257669.1 ENSMUSG00000123320 ENSMUST00000257669.1 ENSMUSG00000123320 (from geneSymbol) uc332cmv.1 uc332cmv.1 
ENSMUST00000257670.1 ENSMUSG00000123321 ENSMUST00000257670.1 ENSMUSG00000123321 (from geneSymbol) uc332cmw.1 uc332cmw.1 
ENSMUST00000257671.1 ENSMUSG00000123322 ENSMUST00000257671.1 ENSMUSG00000123322 (from geneSymbol) uc332cmx.1 uc332cmx.1 
ENSMUST00000257673.1 ENSMUSG00000123323 ENSMUST00000257673.1 ENSMUSG00000123323 (from geneSymbol) uc332cmz.1 uc332cmz.1 
ENSMUST00000257676.1 ENSMUSG00000123324 ENSMUST00000257676.1 ENSMUSG00000123324 (from geneSymbol) uc332cnc.1 uc332cnc.1 
ENSMUST00000257681.1 Gm56807 ENSMUST00000257681.1 Gm56807 (from geneSymbol) uc332cnh.1 uc332cnh.1 
ENSMUST00000257714.1 ENSMUSG00000123325 ENSMUST00000257714.1 ENSMUSG00000123325 (from geneSymbol) uc332con.1 uc332con.1 
ENSMUST00000257718.1 ENSMUSG00000123326 ENSMUST00000257718.1 ENSMUSG00000123326 (from geneSymbol) uc332cor.1 uc332cor.1 
ENSMUST00000257719.1 Gm14167 ENSMUST00000257719.1 Gm14167 (from geneSymbol) uc332cos.1 uc332cos.1 
ENSMUST00000257737.1 Gm20616 ENSMUST00000257737.1 Gm20616 (from geneSymbol) AK076909 uc332cpk.1 uc332cpk.1 
ENSMUST00000257741.1 ENSMUSG00000123327 ENSMUST00000257741.1 ENSMUSG00000123327 (from geneSymbol) uc332cpo.1 uc332cpo.1 
ENSMUST00000257742.1 ENSMUSG00000123328 ENSMUST00000257742.1 ENSMUSG00000123328 (from geneSymbol) uc332cpp.1 uc332cpp.1 
ENSMUST00000257744.1 ENSMUSG00000123329 ENSMUST00000257744.1 ENSMUSG00000123329 (from geneSymbol) uc332cpr.1 uc332cpr.1 
ENSMUST00000257745.1 ENSMUSG00000123330 ENSMUST00000257745.1 ENSMUSG00000123330 (from geneSymbol) uc332cps.1 uc332cps.1 
ENSMUST00000257758.1 ENSMUSG00000123331 ENSMUST00000257758.1 ENSMUSG00000123331 (from geneSymbol) uc332cqf.1 uc332cqf.1 
ENSMUST00000257759.1 ENSMUSG00000123332 ENSMUST00000257759.1 ENSMUSG00000123332 (from geneSymbol) uc332cqg.1 uc332cqg.1 
ENSMUST00000257761.1 ENSMUSG00000123333 ENSMUST00000257761.1 ENSMUSG00000123333 (from geneSymbol) uc332cqi.1 uc332cqi.1 
ENSMUST00000257762.1 ENSMUSG00000123334 ENSMUST00000257762.1 ENSMUSG00000123334 (from geneSymbol) uc332cqj.1 uc332cqj.1 
ENSMUST00000257764.1 ENSMUSG00000123335 ENSMUST00000257764.1 ENSMUSG00000123335 (from geneSymbol) uc332cql.1 uc332cql.1 
ENSMUST00000257765.1 ENSMUSG00000123336 ENSMUST00000257765.1 ENSMUSG00000123336 (from geneSymbol) uc332cqm.1 uc332cqm.1 
ENSMUST00000257767.1 ENSMUSG00000123337 ENSMUST00000257767.1 ENSMUSG00000123337 (from geneSymbol) uc332cqo.1 uc332cqo.1 
ENSMUST00000257768.1 ENSMUSG00000123338 ENSMUST00000257768.1 ENSMUSG00000123338 (from geneSymbol) uc332cqp.1 uc332cqp.1 
ENSMUST00000257769.1 ENSMUSG00000123339 ENSMUST00000257769.1 ENSMUSG00000123339 (from geneSymbol) LF198479 uc332cqq.1 uc332cqq.1 
ENSMUST00000257770.1 ENSMUSG00000123340 ENSMUST00000257770.1 ENSMUSG00000123340 (from geneSymbol) uc332cqr.1 uc332cqr.1 
ENSMUST00000257771.1 ENSMUSG00000123341 ENSMUST00000257771.1 ENSMUSG00000123341 (from geneSymbol) uc332cqs.1 uc332cqs.1 
ENSMUST00000257773.1 ENSMUSG00000123342 ENSMUST00000257773.1 ENSMUSG00000123342 (from geneSymbol) uc332cqu.1 uc332cqu.1 
ENSMUST00000257796.1 ENSMUSG00000123343 ENSMUST00000257796.1 ENSMUSG00000123343 (from geneSymbol) uc332crr.1 uc332crr.1 
ENSMUST00000257806.1 ENSMUSG00000123344 ENSMUST00000257806.1 ENSMUSG00000123344 (from geneSymbol) uc332csb.1 uc332csb.1 
ENSMUST00000257807.1 ENSMUSG00000123345 ENSMUST00000257807.1 ENSMUSG00000123345 (from geneSymbol) uc332csc.1 uc332csc.1 
ENSMUST00000257809.1 ENSMUSG00000123346 ENSMUST00000257809.1 ENSMUSG00000123346 (from geneSymbol) uc332cse.1 uc332cse.1 
ENSMUST00000257812.1 ENSMUSG00000123347 ENSMUST00000257812.1 ENSMUSG00000123347 (from geneSymbol) uc332csh.1 uc332csh.1 
ENSMUST00000257817.1 Gm32710 ENSMUST00000257817.1 Gm32710 (from geneSymbol) uc332csk.1 uc332csk.1 
ENSMUST00000257821.1 ENSMUSG00000123349 ENSMUST00000257821.1 ENSMUSG00000123349 (from geneSymbol) uc332cso.1 uc332cso.1 
ENSMUST00000257826.1 ENSMUSG00000123350 ENSMUST00000257826.1 ENSMUSG00000123350 (from geneSymbol) uc332cst.1 uc332cst.1 
ENSMUST00000257829.1 ENSMUSG00000123351 ENSMUST00000257829.1 ENSMUSG00000123351 (from geneSymbol) uc332csw.1 uc332csw.1 
ENSMUST00000257842.1 ENSMUSG00000123352 ENSMUST00000257842.1 ENSMUSG00000123352 (from geneSymbol) KY468073 uc332ctj.1 uc332ctj.1 
ENSMUST00000257855.1 Gm44662 ENSMUST00000257855.1 Gm44662 (from geneSymbol) uc332ctw.1 uc332ctw.1 
ENSMUST00000257870.1 ENSMUSG00000123353 ENSMUST00000257870.1 ENSMUSG00000123353 (from geneSymbol) uc332cul.1 uc332cul.1 
ENSMUST00000257871.1 Gm12374 ENSMUST00000257871.1 Gm12374 (from geneSymbol) AK029761 uc332cum.1 uc332cum.1 
ENSMUST00000257881.1 ENSMUSG00000123354 ENSMUST00000257881.1 ENSMUSG00000123354 (from geneSymbol) uc332cuw.1 uc332cuw.1 
ENSMUST00000257886.1 Gm43450 ENSMUST00000257886.1 Gm43450 (from geneSymbol) uc332cvb.1 uc332cvb.1 
ENSMUST00000257893.1 ENSMUSG00000123355 ENSMUST00000257893.1 ENSMUSG00000123355 (from geneSymbol) uc332cvi.1 uc332cvi.1 
ENSMUST00000257895.1 ENSMUSG00000123356 ENSMUST00000257895.1 ENSMUSG00000123356 (from geneSymbol) uc332cvk.1 uc332cvk.1 
ENSMUST00000257986.1 ENSMUSG00000123357 ENSMUST00000257986.1 ENSMUSG00000123357 (from geneSymbol) uc332cyu.1 uc332cyu.1 
ENSMUST00000257987.1 ENSMUSG00000123358 ENSMUST00000257987.1 ENSMUSG00000123358 (from geneSymbol) uc332cyv.1 uc332cyv.1 
ENSMUST00000257995.1 ENSMUSG00000123359 ENSMUST00000257995.1 ENSMUSG00000123359 (from geneSymbol) uc332czd.1 uc332czd.1 
ENSMUST00000257996.1 ENSMUSG00000123360 ENSMUST00000257996.1 ENSMUSG00000123360 (from geneSymbol) uc332cze.1 uc332cze.1 
ENSMUST00000257998.1 ENSMUSG00000123361 ENSMUST00000257998.1 ENSMUSG00000123361 (from geneSymbol) uc332czg.1 uc332czg.1 
ENSMUST00000257999.1 ENSMUSG00000123362 ENSMUST00000257999.1 ENSMUSG00000123362 (from geneSymbol) uc332czh.1 uc332czh.1 
ENSMUST00000258002.1 ENSMUSG00000123363 ENSMUST00000258002.1 ENSMUSG00000123363 (from geneSymbol) uc332czk.1 uc332czk.1 
ENSMUST00000258014.1 ENSMUSG00000123364 ENSMUST00000258014.1 ENSMUSG00000123364 (from geneSymbol) uc332czw.1 uc332czw.1 
ENSMUST00000258016.1 ENSMUSG00000123365 ENSMUST00000258016.1 ENSMUSG00000123365 (from geneSymbol) uc332czy.1 uc332czy.1 
ENSMUST00000258018.1 ENSMUSG00000123366 ENSMUST00000258018.1 ENSMUSG00000123366 (from geneSymbol) uc332daa.1 uc332daa.1 
ENSMUST00000258020.1 ENSMUSG00000123367 ENSMUST00000258020.1 ENSMUSG00000123367 (from geneSymbol) BC100414 uc332dac.1 uc332dac.1 
ENSMUST00000258021.1 ENSMUSG00000123368 ENSMUST00000258021.1 ENSMUSG00000123368 (from geneSymbol) uc332dad.1 uc332dad.1 
ENSMUST00000258024.1 ENSMUSG00000123369 ENSMUST00000258024.1 ENSMUSG00000123369 (from geneSymbol) uc332dag.1 uc332dag.1 
ENSMUST00000258025.1 ENSMUSG00000123370 ENSMUST00000258025.1 ENSMUSG00000123370 (from geneSymbol) uc332dah.1 uc332dah.1 
ENSMUST00000258027.1 ENSMUSG00000123371 ENSMUST00000258027.1 ENSMUSG00000123371 (from geneSymbol) uc332daj.1 uc332daj.1 
ENSMUST00000258030.1 ENSMUSG00000123372 ENSMUST00000258030.1 ENSMUSG00000123372 (from geneSymbol) uc332dam.1 uc332dam.1 
ENSMUST00000258031.1 ENSMUSG00000123373 ENSMUST00000258031.1 ENSMUSG00000123373 (from geneSymbol) uc332dan.1 uc332dan.1 
ENSMUST00000258033.1 4930528P14Rik ENSMUST00000258033.1 4930528P14Rik (from geneSymbol) AK019710 uc332dap.1 uc332dap.1 
ENSMUST00000258042.1 ENSMUSG00000123374 ENSMUST00000258042.1 ENSMUSG00000123374 (from geneSymbol) uc332day.1 uc332day.1 
ENSMUST00000258044.1 ENSMUSG00000123375 ENSMUST00000258044.1 ENSMUSG00000123375 (from geneSymbol) uc332dba.1 uc332dba.1 
ENSMUST00000258050.1 ENSMUSG00000123376 ENSMUST00000258050.1 ENSMUSG00000123376 (from geneSymbol) uc332dbg.1 uc332dbg.1 
ENSMUST00000258053.1 ENSMUSG00000123377 ENSMUST00000258053.1 ENSMUSG00000123377 (from geneSymbol) uc332dbj.1 uc332dbj.1 
ENSMUST00000258054.1 4933434M16Rik ENSMUST00000258054.1 4933434M16Rik (from geneSymbol) AK017060 uc332dbk.1 uc332dbk.1 
ENSMUST00000258058.1 ENSMUSG00000123378 ENSMUST00000258058.1 ENSMUSG00000123378 (from geneSymbol) uc332dbo.1 uc332dbo.1 
ENSMUST00000258061.1 ENSMUSG00000123379 ENSMUST00000258061.1 ENSMUSG00000123379 (from geneSymbol) uc332dbr.1 uc332dbr.1 
ENSMUST00000258062.1 ENSMUSG00000123380 ENSMUST00000258062.1 ENSMUSG00000123380 (from geneSymbol) uc332dbs.1 uc332dbs.1 
ENSMUST00000258068.1 ENSMUSG00000123381 ENSMUST00000258068.1 ENSMUSG00000123381 (from geneSymbol) uc332dby.1 uc332dby.1 
ENSMUST00000258077.1 ENSMUSG00000123382 ENSMUST00000258077.1 ENSMUSG00000123382 (from geneSymbol) uc332dch.1 uc332dch.1 
ENSMUST00000258079.1 ENSMUSG00000123383 ENSMUST00000258079.1 ENSMUSG00000123383 (from geneSymbol) uc332dcj.1 uc332dcj.1 
ENSMUST00000258082.1 ENSMUSG00000123384 ENSMUST00000258082.1 ENSMUSG00000123384 (from geneSymbol) uc332dcm.1 uc332dcm.1 
ENSMUST00000258096.1 ENSMUSG00000123385 ENSMUST00000258096.1 ENSMUSG00000123385 (from geneSymbol) uc332dda.1 uc332dda.1 
ENSMUST00000258098.1 ENSMUSG00000123386 ENSMUST00000258098.1 ENSMUSG00000123386 (from geneSymbol) AK076896 uc332ddc.1 uc332ddc.1 
ENSMUST00000258099.1 ENSMUSG00000123387 ENSMUST00000258099.1 ENSMUSG00000123387 (from geneSymbol) uc332ddd.1 uc332ddd.1 
ENSMUST00000258100.1 Gm30085 ENSMUST00000258100.1 Gm30085 (from geneSymbol) KY467736 uc332dde.1 uc332dde.1 
ENSMUST00000258123.1 ENSMUSG00000123389 ENSMUST00000258123.1 ENSMUSG00000123389 (from geneSymbol) uc332dea.1 uc332dea.1 
ENSMUST00000258124.1 ENSMUSG00000123390 ENSMUST00000258124.1 ENSMUSG00000123390 (from geneSymbol) uc332deb.1 uc332deb.1 
ENSMUST00000258134.1 Gm40330 ENSMUST00000258134.1 Gm40330 (from geneSymbol) uc332del.1 uc332del.1 
ENSMUST00000258145.1 ENSMUSG00000123391 ENSMUST00000258145.1 ENSMUSG00000123391 (from geneSymbol) uc332dew.1 uc332dew.1 
ENSMUST00000258147.1 ENSMUSG00000123392 ENSMUST00000258147.1 ENSMUSG00000123392 (from geneSymbol) uc332dey.1 uc332dey.1 
ENSMUST00000258148.1 ENSMUSG00000123393 ENSMUST00000258148.1 ENSMUSG00000123393 (from geneSymbol) uc332dez.1 uc332dez.1 
ENSMUST00000258149.1 ENSMUSG00000123394 ENSMUST00000258149.1 ENSMUSG00000123394 (from geneSymbol) uc332dfa.1 uc332dfa.1 
ENSMUST00000258150.1 ENSMUSG00000123395 ENSMUST00000258150.1 ENSMUSG00000123395 (from geneSymbol) uc332dfb.1 uc332dfb.1 
ENSMUST00000258154.1 ENSMUSG00000123396 ENSMUST00000258154.1 ENSMUSG00000123396 (from geneSymbol) uc332dff.1 uc332dff.1 
ENSMUST00000258155.1 ENSMUSG00000123397 ENSMUST00000258155.1 ENSMUSG00000123397 (from geneSymbol) uc332dfg.1 uc332dfg.1 
ENSMUST00000258156.1 ENSMUSG00000123398 ENSMUST00000258156.1 ENSMUSG00000123398 (from geneSymbol) uc332dfh.1 uc332dfh.1 
ENSMUST00000258159.1 ENSMUSG00000123399 ENSMUST00000258159.1 ENSMUSG00000123399 (from geneSymbol) uc332dfk.1 uc332dfk.1 
ENSMUST00000258160.1 ENSMUSG00000123400 ENSMUST00000258160.1 ENSMUSG00000123400 (from geneSymbol) uc332dfl.1 uc332dfl.1 
ENSMUST00000258161.1 ENSMUSG00000123401 ENSMUST00000258161.1 ENSMUSG00000123401 (from geneSymbol) uc332dfm.1 uc332dfm.1 
ENSMUST00000258163.1 ENSMUSG00000123402 ENSMUST00000258163.1 ENSMUSG00000123402 (from geneSymbol) uc332dfo.1 uc332dfo.1 
ENSMUST00000258171.1 ENSMUSG00000123403 ENSMUST00000258171.1 ENSMUSG00000123403 (from geneSymbol) uc332dfw.1 uc332dfw.1 
ENSMUST00000258172.1 Gm39168 ENSMUST00000258172.1 Gm39168 (from geneSymbol) AK078582 uc332dfx.1 uc332dfx.1 
ENSMUST00000258173.1 D030055H07Rik ENSMUST00000258173.1 D030055H07Rik (from geneSymbol) AK051019 uc332dfy.1 uc332dfy.1 
ENSMUST00000258180.1 ENSMUSG00000123404 ENSMUST00000258180.1 ENSMUSG00000123404 (from geneSymbol) uc332dgf.1 uc332dgf.1 
ENSMUST00000258181.1 ENSMUSG00000123405 ENSMUST00000258181.1 ENSMUSG00000123405 (from geneSymbol) uc332dgg.1 uc332dgg.1 
ENSMUST00000258183.1 ENSMUSG00000123406 ENSMUST00000258183.1 ENSMUSG00000123406 (from geneSymbol) uc332dgi.1 uc332dgi.1 
ENSMUST00000258190.1 ENSMUSG00000123407 ENSMUST00000258190.1 ENSMUSG00000123407 (from geneSymbol) uc332dgp.1 uc332dgp.1 
ENSMUST00000258193.1 ENSMUSG00000123408 ENSMUST00000258193.1 ENSMUSG00000123408 (from geneSymbol) uc332dgq.1 uc332dgq.1 
ENSMUST00000258196.1 ENSMUSG00000123409 ENSMUST00000258196.1 ENSMUSG00000123409 (from geneSymbol) uc332dgt.1 uc332dgt.1 
ENSMUST00000258203.1 ENSMUSG00000123410 ENSMUST00000258203.1 ENSMUSG00000123410 (from geneSymbol) uc332dha.1 uc332dha.1 
ENSMUST00000258204.1 ENSMUSG00000123411 ENSMUST00000258204.1 ENSMUSG00000123411 (from geneSymbol) uc332dhb.1 uc332dhb.1 
ENSMUST00000258205.1 ENSMUSG00000123412 ENSMUST00000258205.1 ENSMUSG00000123412 (from geneSymbol) uc332dhc.1 uc332dhc.1 
ENSMUST00000258210.1 ENSMUSG00000123413 ENSMUST00000258210.1 ENSMUSG00000123413 (from geneSymbol) uc332dhh.1 uc332dhh.1 
ENSMUST00000258216.1 Gm13976 ENSMUST00000258216.1 Gm13976 (from geneSymbol) uc332dhn.1 uc332dhn.1 
ENSMUST00000258225.1 ENSMUSG00000123414 ENSMUST00000258225.1 ENSMUSG00000123414 (from geneSymbol) uc332dhw.1 uc332dhw.1 
ENSMUST00000258226.1 ENSMUSG00000123415 ENSMUST00000258226.1 ENSMUSG00000123415 (from geneSymbol) uc332dhx.1 uc332dhx.1 
ENSMUST00000258234.1 Gm32209 ENSMUST00000258234.1 Gm32209 (from geneSymbol) uc332dif.1 uc332dif.1 
ENSMUST00000258249.1 ENSMUSG00000123417 ENSMUST00000258249.1 ENSMUSG00000123417 (from geneSymbol) uc332diu.1 uc332diu.1 
ENSMUST00000258253.1 1700012H19Rik ENSMUST00000258253.1 1700012H19Rik (from geneSymbol) AK005912 uc332diy.1 uc332diy.1 
ENSMUST00000258260.1 ENSMUSG00000123419 ENSMUST00000258260.1 ENSMUSG00000123419 (from geneSymbol) uc332djf.1 uc332djf.1 
ENSMUST00000258261.1 ENSMUSG00000123420 ENSMUST00000258261.1 ENSMUSG00000123420 (from geneSymbol) AK014845 uc332djg.1 uc332djg.1 
ENSMUST00000258266.1 ENSMUSG00000123421 ENSMUST00000258266.1 ENSMUSG00000123421 (from geneSymbol) uc332djl.1 uc332djl.1 
ENSMUST00000258271.1 ENSMUSG00000123422 ENSMUST00000258271.1 ENSMUSG00000123422 (from geneSymbol) uc332djq.1 uc332djq.1 
ENSMUST00000258273.1 ENSMUSG00000123423 ENSMUST00000258273.1 ENSMUSG00000123423 (from geneSymbol) uc332djs.1 uc332djs.1 
ENSMUST00000258274.1 ENSMUSG00000123424 ENSMUST00000258274.1 ENSMUSG00000123424 (from geneSymbol) uc332djt.1 uc332djt.1 
ENSMUST00000258276.1 ENSMUSG00000123425 ENSMUST00000258276.1 ENSMUSG00000123425 (from geneSymbol) uc332djv.1 uc332djv.1 
ENSMUST00000258277.1 ENSMUSG00000123426 ENSMUST00000258277.1 ENSMUSG00000123426 (from geneSymbol) uc332djw.1 uc332djw.1 
ENSMUST00000258279.1 ENSMUSG00000123427 ENSMUST00000258279.1 ENSMUSG00000123427 (from geneSymbol) uc332djy.1 uc332djy.1 
ENSMUST00000258280.1 ENSMUSG00000123428 ENSMUST00000258280.1 ENSMUSG00000123428 (from geneSymbol) uc332djz.1 uc332djz.1 
ENSMUST00000258283.1 ENSMUSG00000123429 ENSMUST00000258283.1 ENSMUSG00000123429 (from geneSymbol) uc332dkc.1 uc332dkc.1 
ENSMUST00000258285.1 ENSMUSG00000123430 ENSMUST00000258285.1 ENSMUSG00000123430 (from geneSymbol) uc332dke.1 uc332dke.1 
ENSMUST00000258295.1 ENSMUSG00000123431 ENSMUST00000258295.1 ENSMUSG00000123431 (from geneSymbol) uc332dko.1 uc332dko.1 
ENSMUST00000258296.1 ENSMUSG00000123432 ENSMUST00000258296.1 ENSMUSG00000123432 (from geneSymbol) uc332dkp.1 uc332dkp.1 
ENSMUST00000258297.1 ENSMUSG00000123433 ENSMUST00000258297.1 ENSMUSG00000123433 (from geneSymbol) uc332dkq.1 uc332dkq.1 
ENSMUST00000258299.1 Pmepa1os ENSMUST00000258299.1 Pmepa1os (from geneSymbol) AK145161 uc332dks.1 uc332dks.1 
ENSMUST00000258305.1 ENSMUSG00000123434 ENSMUST00000258305.1 ENSMUSG00000123434 (from geneSymbol) uc332dky.1 uc332dky.1 
ENSMUST00000258310.1 ENSMUSG00000123436 ENSMUST00000258310.1 ENSMUSG00000123436 (from geneSymbol) uc332dlb.1 uc332dlb.1 
ENSMUST00000258312.1 ENSMUSG00000123437 ENSMUST00000258312.1 ENSMUSG00000123437 (from geneSymbol) uc332dld.1 uc332dld.1 
ENSMUST00000258315.1 1700121C08Rik ENSMUST00000258315.1 1700121C08Rik (from geneSymbol) uc332dlg.1 uc332dlg.1 
ENSMUST00000258329.1 Gm21302 ENSMUST00000258329.1 Gm21302 (from geneSymbol) BC087891 uc332dlu.1 uc332dlu.1 
ENSMUST00000258330.1 ENSMUSG00000123439 ENSMUST00000258330.1 ENSMUSG00000123439 (from geneSymbol) uc332dlv.1 uc332dlv.1 
ENSMUST00000258331.1 Gm57227 ENSMUST00000258331.1 Gm57227 (from geneSymbol) AK131900 uc332dlw.1 uc332dlw.1 
ENSMUST00000258334.1 ENSMUSG00000123440 ENSMUST00000258334.1 ENSMUSG00000123440 (from geneSymbol) uc332dlz.1 uc332dlz.1 
ENSMUST00000258335.1 Gm32900 ENSMUST00000258335.1 Gm32900 (from geneSymbol) KY467945 uc332dma.1 uc332dma.1 
ENSMUST00000258362.1 ENSMUSG00000123442 ENSMUST00000258362.1 ENSMUSG00000123442 (from geneSymbol) uc332dnb.1 uc332dnb.1 
ENSMUST00000258363.1 ENSMUSG00000123443 ENSMUST00000258363.1 ENSMUSG00000123443 (from geneSymbol) uc332dnc.1 uc332dnc.1 
ENSMUST00000258364.1 ENSMUSG00000123444 ENSMUST00000258364.1 ENSMUSG00000123444 (from geneSymbol) AB352992 uc332dnd.1 uc332dnd.1 
ENSMUST00000258365.1 ENSMUSG00000123445 ENSMUST00000258365.1 ENSMUSG00000123445 (from geneSymbol) uc332dne.1 uc332dne.1 
ENSMUST00000258366.1 ENSMUSG00000123446 ENSMUST00000258366.1 ENSMUSG00000123446 (from geneSymbol) uc332dnf.1 uc332dnf.1 
ENSMUST00000258369.1 ENSMUSG00000123447 ENSMUST00000258369.1 ENSMUSG00000123447 (from geneSymbol) uc332dni.1 uc332dni.1 
ENSMUST00000258370.1 ENSMUSG00000123448 ENSMUST00000258370.1 ENSMUSG00000123448 (from geneSymbol) uc332dnj.1 uc332dnj.1 
ENSMUST00000258371.1 ENSMUSG00000123449 ENSMUST00000258371.1 ENSMUSG00000123449 (from geneSymbol) uc332dnk.1 uc332dnk.1 
ENSMUST00000258374.1 ENSMUSG00000123450 ENSMUST00000258374.1 ENSMUSG00000123450 (from geneSymbol) AK015356 uc332dnn.1 uc332dnn.1 
ENSMUST00000258376.1 ENSMUSG00000123451 ENSMUST00000258376.1 ENSMUSG00000123451 (from geneSymbol) uc332dnp.1 uc332dnp.1 
ENSMUST00000258378.1 ENSMUSG00000123452 ENSMUST00000258378.1 ENSMUSG00000123452 (from geneSymbol) uc332dnr.1 uc332dnr.1 
ENSMUST00000258382.1 ENSMUSG00000123455 ENSMUST00000258382.1 ENSMUSG00000123455 (from geneSymbol) uc332dns.1 uc332dns.1 
ENSMUST00000258383.1 ENSMUSG00000123456 ENSMUST00000258383.1 ENSMUSG00000123456 (from geneSymbol) uc332dnt.1 uc332dnt.1 
ENSMUST00000258388.1 ENSMUSG00000123457 ENSMUST00000258388.1 ENSMUSG00000123457 (from geneSymbol) uc332dny.1 uc332dny.1 
ENSMUST00000258389.1 Gm12992 ENSMUST00000258389.1 Gm12992 (from geneSymbol) AK047558 uc332dnz.1 uc332dnz.1 
ENSMUST00000258391.1 ENSMUSG00000123458 ENSMUST00000258391.1 ENSMUSG00000123458 (from geneSymbol) uc332dob.1 uc332dob.1 
ENSMUST00000258401.1 ENSMUSG00000123459 ENSMUST00000258401.1 ENSMUSG00000123459 (from geneSymbol) uc332dol.1 uc332dol.1 
ENSMUST00000258406.1 Gm47077 ENSMUST00000258406.1 Gm47077 (from geneSymbol) AK007286 uc332doq.1 uc332doq.1 
ENSMUST00000258407.1 ENSMUSG00000123460 ENSMUST00000258407.1 ENSMUSG00000123460 (from geneSymbol) uc332dor.1 uc332dor.1 
ENSMUST00000258408.1 Gm46124 ENSMUST00000258408.1 Gm46124 (from geneSymbol) uc332dos.1 uc332dos.1 
ENSMUST00000258410.1 ENSMUSG00000123461 ENSMUST00000258410.1 ENSMUSG00000123461 (from geneSymbol) uc332dou.1 uc332dou.1 
ENSMUST00000258415.1 ENSMUSG00000123462 ENSMUST00000258415.1 ENSMUSG00000123462 (from geneSymbol) uc332doz.1 uc332doz.1 
ENSMUST00000258421.1 Gm37083 ENSMUST00000258421.1 Gm37083 (from geneSymbol) uc332dpf.1 uc332dpf.1 
ENSMUST00000258432.1 ENSMUSG00000123463 ENSMUST00000258432.1 ENSMUSG00000123463 (from geneSymbol) uc332dpq.1 uc332dpq.1 
ENSMUST00000258436.1 ENSMUSG00000123464 ENSMUST00000258436.1 ENSMUSG00000123464 (from geneSymbol) uc332dpu.1 uc332dpu.1 
ENSMUST00000258437.1 ENSMUSG00000123465 ENSMUST00000258437.1 ENSMUSG00000123465 (from geneSymbol) uc332dpv.1 uc332dpv.1 
ENSMUST00000258441.1 ENSMUSG00000123466 ENSMUST00000258441.1 ENSMUSG00000123466 (from geneSymbol) uc332dpz.1 uc332dpz.1 
ENSMUST00000258452.1 ENSMUSG00000123467 ENSMUST00000258452.1 ENSMUSG00000123467 (from geneSymbol) uc332dqk.1 uc332dqk.1 
ENSMUST00000258453.1 ENSMUSG00000123468 ENSMUST00000258453.1 ENSMUSG00000123468 (from geneSymbol) uc332dql.1 uc332dql.1 
ENSMUST00000258454.1 Gm19265 ENSMUST00000258454.1 Gm19265 (from geneSymbol) AK016112 uc332dqm.1 uc332dqm.1 
ENSMUST00000258458.1 ENSMUSG00000123469 ENSMUST00000258458.1 ENSMUSG00000123469 (from geneSymbol) uc332dqq.1 uc332dqq.1 
ENSMUST00000258466.1 Gm56750 ENSMUST00000258466.1 Gm56750 (from geneSymbol) uc332dqy.1 uc332dqy.1 
ENSMUST00000258468.1 ENSMUSG00000123470 ENSMUST00000258468.1 ENSMUSG00000123470 (from geneSymbol) uc332dra.1 uc332dra.1 
ENSMUST00000258469.1 ENSMUSG00000123471 ENSMUST00000258469.1 ENSMUSG00000123471 (from geneSymbol) uc332drb.1 uc332drb.1 
ENSMUST00000258471.1 ENSMUSG00000123472 ENSMUST00000258471.1 ENSMUSG00000123472 (from geneSymbol) uc332drd.1 uc332drd.1 
ENSMUST00000258472.1 Gm28294 ENSMUST00000258472.1 Gm28294 (from geneSymbol) uc332dre.1 uc332dre.1 
ENSMUST00000258479.1 ENSMUSG00000123473 ENSMUST00000258479.1 ENSMUSG00000123473 (from geneSymbol) uc332drl.1 uc332drl.1 
ENSMUST00000258482.1 ENSMUSG00000123474 ENSMUST00000258482.1 ENSMUSG00000123474 (from geneSymbol) uc332dro.1 uc332dro.1 
ENSMUST00000258483.1 ENSMUSG00000123475 ENSMUST00000258483.1 ENSMUSG00000123475 (from geneSymbol) uc332drp.1 uc332drp.1 
ENSMUST00000258485.1 Gm21330 ENSMUST00000258485.1 Gm21330 (from geneSymbol) BC089465 uc332drr.1 uc332drr.1 
ENSMUST00000258486.1 ENSMUSG00000123477 ENSMUST00000258486.1 ENSMUSG00000123477 (from geneSymbol) uc332drs.1 uc332drs.1 
ENSMUST00000258487.1 ENSMUSG00000123478 ENSMUST00000258487.1 ENSMUSG00000123478 (from geneSymbol) uc332drt.1 uc332drt.1 
ENSMUST00000258489.1 ENSMUSG00000123479 ENSMUST00000258489.1 ENSMUSG00000123479 (from geneSymbol) DQ558866 uc332drv.1 uc332drv.1 
ENSMUST00000258490.1 ENSMUSG00000123480 ENSMUST00000258490.1 ENSMUSG00000123480 (from geneSymbol) uc332drw.1 uc332drw.1 
ENSMUST00000258496.1 A430046D13Rik ENSMUST00000258496.1 A430046D13Rik (from geneSymbol) AK040027 uc332dsc.1 uc332dsc.1 
ENSMUST00000258534.1 ENSMUSG00000123481 ENSMUST00000258534.1 ENSMUSG00000123481 (from geneSymbol) uc332dto.1 uc332dto.1 
ENSMUST00000258536.1 ENSMUSG00000123482 ENSMUST00000258536.1 ENSMUSG00000123482 (from geneSymbol) uc332dtq.1 uc332dtq.1 
ENSMUST00000258538.1 Gm32780 ENSMUST00000258538.1 Gm32780 (from geneSymbol) uc332dts.1 uc332dts.1 
ENSMUST00000258550.1 4930423M02Rik ENSMUST00000258550.1 4930423M02Rik (from geneSymbol) AK015191 uc332due.1 uc332due.1 
ENSMUST00000258567.1 ENSMUSG00000123484 ENSMUST00000258567.1 ENSMUSG00000123484 (from geneSymbol) uc332dut.1 uc332dut.1 
ENSMUST00000258570.1 ENSMUSG00000123485 ENSMUST00000258570.1 ENSMUSG00000123485 (from geneSymbol) uc332duw.1 uc332duw.1 
ENSMUST00000258573.1 ENSMUSG00000123486 ENSMUST00000258573.1 ENSMUSG00000123486 (from geneSymbol) uc332duz.1 uc332duz.1 
ENSMUST00000258575.1 ENSMUSG00000123487 ENSMUST00000258575.1 ENSMUSG00000123487 (from geneSymbol) uc332dvb.1 uc332dvb.1 
ENSMUST00000258576.1 ENSMUSG00000123488 ENSMUST00000258576.1 ENSMUSG00000123488 (from geneSymbol) uc332dvc.1 uc332dvc.1 
ENSMUST00000258577.1 ENSMUSG00000123489 ENSMUST00000258577.1 ENSMUSG00000123489 (from geneSymbol) uc332dvd.1 uc332dvd.1 
ENSMUST00000258578.1 Gm56849 ENSMUST00000258578.1 Gm56849 (from geneSymbol) uc332dve.1 uc332dve.1 
ENSMUST00000258580.1 ENSMUSG00000123490 ENSMUST00000258580.1 ENSMUSG00000123490 (from geneSymbol) uc332dvg.1 uc332dvg.1 
ENSMUST00000258595.1 1700025K24Rik ENSMUST00000258595.1 1700025K24Rik (from geneSymbol) AK006354 uc332dvv.1 uc332dvv.1 
ENSMUST00000258610.1 ENSMUSG00000123491 ENSMUST00000258610.1 ENSMUSG00000123491 (from geneSymbol) U34281 uc332dwk.1 uc332dwk.1 
ENSMUST00000258621.1 ENSMUSG00000123492 ENSMUST00000258621.1 ENSMUSG00000123492 (from geneSymbol) uc332dwv.1 uc332dwv.1 
ENSMUST00000258637.1 ENSMUSG00000123493 ENSMUST00000258637.1 ENSMUSG00000123493 (from geneSymbol) uc332dxl.1 uc332dxl.1 
ENSMUST00000258643.1 ENSMUSG00000123494 ENSMUST00000258643.1 ENSMUSG00000123494 (from geneSymbol) uc332dxr.1 uc332dxr.1 
ENSMUST00000258645.1 1700084F23Rik ENSMUST00000258645.1 1700084F23Rik (from geneSymbol) AK006991 uc332dxt.1 uc332dxt.1 
ENSMUST00000258710.1 Gm34000 ENSMUST00000258710.1 Gm34000 (from geneSymbol) uc332eag.1 uc332eag.1 
ENSMUST00000258714.1 ENSMUSG00000123496 ENSMUST00000258714.1 ENSMUSG00000123496 (from geneSymbol) uc332eak.1 uc332eak.1 
ENSMUST00000258715.1 4930548J01Rik ENSMUST00000258715.1 4930548J01Rik (from geneSymbol) AK007199 uc332eal.1 uc332eal.1 
ENSMUST00000258726.1 4930579O11Rik ENSMUST00000258726.1 4930579O11Rik (from geneSymbol) AK016331 uc332eaw.1 uc332eaw.1 
ENSMUST00000258727.1 Gm43573 ENSMUST00000258727.1 Gm43573 (from geneSymbol) uc332eax.1 uc332eax.1 
ENSMUST00000258748.1 Gm30018 ENSMUST00000258748.1 Gm30018 (from geneSymbol) uc332ebs.1 uc332ebs.1 
ENSMUST00000258758.1 ENSMUSG00000123497 ENSMUST00000258758.1 ENSMUSG00000123497 (from geneSymbol) uc332ecc.1 uc332ecc.1 
ENSMUST00000258759.1 ENSMUSG00000123498 ENSMUST00000258759.1 ENSMUSG00000123498 (from geneSymbol) uc332ecd.1 uc332ecd.1 
ENSMUST00000258768.1 ENSMUSG00000123499 ENSMUST00000258768.1 ENSMUSG00000123499 (from geneSymbol) uc332ecm.1 uc332ecm.1 
ENSMUST00000258769.1 ENSMUSG00000123500 ENSMUST00000258769.1 ENSMUSG00000123500 (from geneSymbol) uc332ecn.1 uc332ecn.1 
ENSMUST00000258770.1 ENSMUSG00000123501 ENSMUST00000258770.1 ENSMUSG00000123501 (from geneSymbol) uc332eco.1 uc332eco.1 
ENSMUST00000258771.1 ENSMUSG00000123502 ENSMUST00000258771.1 ENSMUSG00000123502 (from geneSymbol) uc332ecp.1 uc332ecp.1 
ENSMUST00000258772.1 ENSMUSG00000123503 ENSMUST00000258772.1 ENSMUSG00000123503 (from geneSymbol) uc332ecq.1 uc332ecq.1 
ENSMUST00000258776.1 ENSMUSG00000123504 ENSMUST00000258776.1 ENSMUSG00000123504 (from geneSymbol) uc332ecu.1 uc332ecu.1 
ENSMUST00000258779.1 ENSMUSG00000123505 ENSMUST00000258779.1 ENSMUSG00000123505 (from geneSymbol) uc332ecx.1 uc332ecx.1 
ENSMUST00000258780.1 ENSMUSG00000123506 ENSMUST00000258780.1 ENSMUSG00000123506 (from geneSymbol) uc332ecy.1 uc332ecy.1 
ENSMUST00000258785.1 ENSMUSG00000123507 ENSMUST00000258785.1 ENSMUSG00000123507 (from geneSymbol) uc332edd.1 uc332edd.1 
ENSMUST00000258786.1 ENSMUSG00000123508 ENSMUST00000258786.1 ENSMUSG00000123508 (from geneSymbol) uc332ede.1 uc332ede.1 
ENSMUST00000258792.1 ENSMUSG00000123509 ENSMUST00000258792.1 ENSMUSG00000123509 (from geneSymbol) uc332edk.1 uc332edk.1 
ENSMUST00000258804.1 ENSMUSG00000123510 ENSMUST00000258804.1 ENSMUSG00000123510 (from geneSymbol) uc332edw.1 uc332edw.1 
ENSMUST00000258812.1 ENSMUSG00000123511 ENSMUST00000258812.1 ENSMUSG00000123511 (from geneSymbol) uc332eee.1 uc332eee.1 
ENSMUST00000258834.1 6330576A10Rik ENSMUST00000258834.1 6330576A10Rik (from geneSymbol) uc332efa.1 uc332efa.1 
ENSMUST00000258836.1 ENSMUSG00000123512 ENSMUST00000258836.1 ENSMUSG00000123512 (from geneSymbol) uc332efc.1 uc332efc.1 
ENSMUST00000258837.1 ENSMUSG00000123513 ENSMUST00000258837.1 ENSMUSG00000123513 (from geneSymbol) uc332efd.1 uc332efd.1 
ENSMUST00000258840.1 ENSMUSG00000123514 ENSMUST00000258840.1 ENSMUSG00000123514 (from geneSymbol) uc332efg.1 uc332efg.1 
ENSMUST00000258842.1 ENSMUSG00000123515 ENSMUST00000258842.1 ENSMUSG00000123515 (from geneSymbol) uc332efi.1 uc332efi.1 
ENSMUST00000258843.1 ENSMUSG00000123516 ENSMUST00000258843.1 ENSMUSG00000123516 (from geneSymbol) uc332efj.1 uc332efj.1 
ENSMUST00000258846.1 ENSMUSG00000123517 ENSMUST00000258846.1 ENSMUSG00000123517 (from geneSymbol) uc332efm.1 uc332efm.1 
ENSMUST00000258848.1 Gm15179 ENSMUST00000258848.1 Gm15179 (from geneSymbol) AK039780 uc332efn.1 uc332efn.1 
ENSMUST00000258870.1 Gm49200 ENSMUST00000258870.1 Gm49200 (from geneSymbol) uc332egj.1 uc332egj.1 
ENSMUST00000258876.1 ENSMUSG00000123519 ENSMUST00000258876.1 ENSMUSG00000123519 (from geneSymbol) uc332egp.1 uc332egp.1 
ENSMUST00000258877.1 ENSMUSG00000123520 ENSMUST00000258877.1 ENSMUSG00000123520 (from geneSymbol) uc332egq.1 uc332egq.1 
ENSMUST00000258879.1 ENSMUSG00000123521 ENSMUST00000258879.1 ENSMUSG00000123521 (from geneSymbol) uc332egs.1 uc332egs.1 
ENSMUST00000258884.1 ENSMUSG00000123522 ENSMUST00000258884.1 ENSMUSG00000123522 (from geneSymbol) uc332egx.1 uc332egx.1 
ENSMUST00000258885.1 ENSMUSG00000123523 ENSMUST00000258885.1 ENSMUSG00000123523 (from geneSymbol) uc332egy.1 uc332egy.1 
ENSMUST00000258886.1 ENSMUSG00000123524 ENSMUST00000258886.1 ENSMUSG00000123524 (from geneSymbol) uc332egz.1 uc332egz.1 
ENSMUST00000258894.1 ENSMUSG00000123526 ENSMUST00000258894.1 ENSMUSG00000123526 (from geneSymbol) uc332ehg.1 uc332ehg.1 
ENSMUST00000258900.1 ENSMUSG00000123527 ENSMUST00000258900.1 ENSMUSG00000123527 (from geneSymbol) uc332ehm.1 uc332ehm.1 
ENSMUST00000258915.1 ENSMUSG00000123528 ENSMUST00000258915.1 ENSMUSG00000123528 (from geneSymbol) uc332eib.1 uc332eib.1 
ENSMUST00000258916.1 ENSMUSG00000123529 ENSMUST00000258916.1 ENSMUSG00000123529 (from geneSymbol) uc332eic.1 uc332eic.1 
ENSMUST00000258920.1 ENSMUSG00000123530 ENSMUST00000258920.1 ENSMUSG00000123530 (from geneSymbol) uc332eig.1 uc332eig.1 
ENSMUST00000258921.1 ENSMUSG00000123531 ENSMUST00000258921.1 ENSMUSG00000123531 (from geneSymbol) uc332eih.1 uc332eih.1 
ENSMUST00000258924.1 ENSMUSG00000123533 ENSMUST00000258924.1 ENSMUSG00000123533 (from geneSymbol) uc332eij.1 uc332eij.1 
ENSMUST00000258925.1 ENSMUSG00000123534 ENSMUST00000258925.1 ENSMUSG00000123534 (from geneSymbol) uc332eik.1 uc332eik.1 
ENSMUST00000258926.1 ENSMUSG00000123535 ENSMUST00000258926.1 ENSMUSG00000123535 (from geneSymbol) uc332eil.1 uc332eil.1 
ENSMUST00000258929.1 ENSMUSG00000123536 ENSMUST00000258929.1 ENSMUSG00000123536 (from geneSymbol) uc332eio.1 uc332eio.1 
ENSMUST00000258936.1 ENSMUSG00000123537 ENSMUST00000258936.1 ENSMUSG00000123537 (from geneSymbol) uc332eiv.1 uc332eiv.1 
ENSMUST00000258937.1 ENSMUSG00000123538 ENSMUST00000258937.1 ENSMUSG00000123538 (from geneSymbol) uc332eiw.1 uc332eiw.1 
ENSMUST00000258938.1 ENSMUSG00000123539 ENSMUST00000258938.1 ENSMUSG00000123539 (from geneSymbol) uc332eix.1 uc332eix.1 
ENSMUST00000258939.1 ENSMUSG00000123540 ENSMUST00000258939.1 ENSMUSG00000123540 (from geneSymbol) uc332eiy.1 uc332eiy.1 
ENSMUST00000258941.1 Nudt12os ENSMUST00000258941.1 Nudt12os (from geneSymbol) AK132847 uc332eja.1 uc332eja.1 
ENSMUST00000258958.1 ENSMUSG00000123541 ENSMUST00000258958.1 ENSMUSG00000123541 (from geneSymbol) uc332ejr.1 uc332ejr.1 
ENSMUST00000258959.1 ENSMUSG00000123542 ENSMUST00000258959.1 ENSMUSG00000123542 (from geneSymbol) uc332ejs.1 uc332ejs.1 
ENSMUST00000258960.1 ENSMUSG00000123543 ENSMUST00000258960.1 ENSMUSG00000123543 (from geneSymbol) uc332ejt.1 uc332ejt.1 
ENSMUST00000258962.1 ENSMUSG00000123544 ENSMUST00000258962.1 ENSMUSG00000123544 (from geneSymbol) uc332ejv.1 uc332ejv.1 
ENSMUST00000258963.1 ENSMUSG00000123545 ENSMUST00000258963.1 ENSMUSG00000123545 (from geneSymbol) uc332ejw.1 uc332ejw.1 
ENSMUST00000258964.1 ENSMUSG00000123546 ENSMUST00000258964.1 ENSMUSG00000123546 (from geneSymbol) uc332ejx.1 uc332ejx.1 
ENSMUST00000258965.1 ENSMUSG00000123547 ENSMUST00000258965.1 ENSMUSG00000123547 (from geneSymbol) uc332ejy.1 uc332ejy.1 
ENSMUST00000258966.1 ENSMUSG00000123548 ENSMUST00000258966.1 ENSMUSG00000123548 (from geneSymbol) uc332ejz.1 uc332ejz.1 
ENSMUST00000258969.1 ENSMUSG00000123549 ENSMUST00000258969.1 ENSMUSG00000123549 (from geneSymbol) uc332ekc.1 uc332ekc.1 
ENSMUST00000258970.1 ENSMUSG00000123550 ENSMUST00000258970.1 ENSMUSG00000123550 (from geneSymbol) uc332ekd.1 uc332ekd.1 
ENSMUST00000258973.1 5430435K18Rik ENSMUST00000258973.1 5430435K18Rik (from geneSymbol) AK017398 uc332ekg.1 uc332ekg.1 
ENSMUST00000258974.1 ENSMUSG00000123551 ENSMUST00000258974.1 ENSMUSG00000123551 (from geneSymbol) uc332ekh.1 uc332ekh.1 
ENSMUST00000258976.1 ENSMUSG00000123552 ENSMUST00000258976.1 ENSMUSG00000123552 (from geneSymbol) uc332ekj.1 uc332ekj.1 
ENSMUST00000258981.1 ENSMUSG00000123553 ENSMUST00000258981.1 ENSMUSG00000123553 (from geneSymbol) LF204861 uc332eko.1 uc332eko.1 
ENSMUST00000258983.1 ENSMUSG00000123554 ENSMUST00000258983.1 ENSMUSG00000123554 (from geneSymbol) uc332ekq.1 uc332ekq.1 
ENSMUST00000258985.1 ENSMUSG00000123555 ENSMUST00000258985.1 ENSMUSG00000123555 (from geneSymbol) uc332eks.1 uc332eks.1 
ENSMUST00000258986.1 ENSMUSG00000123556 ENSMUST00000258986.1 ENSMUSG00000123556 (from geneSymbol) uc332ekt.1 uc332ekt.1 
ENSMUST00000258987.1 ENSMUSG00000123557 ENSMUST00000258987.1 ENSMUSG00000123557 (from geneSymbol) uc332eku.1 uc332eku.1 
ENSMUST00000258991.1 Gm36703 ENSMUST00000258991.1 Gm36703 (from geneSymbol) uc332eky.1 uc332eky.1 
ENSMUST00000258999.1 ENSMUSG00000123558 ENSMUST00000258999.1 ENSMUSG00000123558 (from geneSymbol) uc332elg.1 uc332elg.1 
ENSMUST00000259021.1 ENSMUSG00000123559 ENSMUST00000259021.1 ENSMUSG00000123559 (from geneSymbol) uc332emc.1 uc332emc.1 
ENSMUST00000259029.1 ENSMUSG00000123560 ENSMUST00000259029.1 ENSMUSG00000123560 (from geneSymbol) uc332emk.1 uc332emk.1 
ENSMUST00000259031.1 ENSMUSG00000123561 ENSMUST00000259031.1 ENSMUSG00000123561 (from geneSymbol) uc332emm.1 uc332emm.1 
ENSMUST00000259032.1 ENSMUSG00000123562 ENSMUST00000259032.1 ENSMUSG00000123562 (from geneSymbol) uc332emn.1 uc332emn.1 
ENSMUST00000259033.1 ENSMUSG00000123563 ENSMUST00000259033.1 ENSMUSG00000123563 (from geneSymbol) uc332emo.1 uc332emo.1 
ENSMUST00000259034.1 ENSMUSG00000123564 ENSMUST00000259034.1 ENSMUSG00000123564 (from geneSymbol) uc332emp.1 uc332emp.1 
ENSMUST00000259037.1 ENSMUSG00000123565 ENSMUST00000259037.1 ENSMUSG00000123565 (from geneSymbol) uc332ems.1 uc332ems.1 
ENSMUST00000259041.1 ENSMUSG00000123566 ENSMUST00000259041.1 ENSMUSG00000123566 (from geneSymbol) uc332emw.1 uc332emw.1 
ENSMUST00000259042.1 ENSMUSG00000123567 ENSMUST00000259042.1 ENSMUSG00000123567 (from geneSymbol) uc332emx.1 uc332emx.1 
ENSMUST00000259043.1 ENSMUSG00000123568 ENSMUST00000259043.1 ENSMUSG00000123568 (from geneSymbol) uc332emy.1 uc332emy.1 
ENSMUST00000259049.1 ENSMUSG00000123569 ENSMUST00000259049.1 ENSMUSG00000123569 (from geneSymbol) uc332ene.1 uc332ene.1 
ENSMUST00000259051.1 ENSMUSG00000123570 ENSMUST00000259051.1 ENSMUSG00000123570 (from geneSymbol) uc332eng.1 uc332eng.1 
ENSMUST00000259053.1 ENSMUSG00000123571 ENSMUST00000259053.1 ENSMUSG00000123571 (from geneSymbol) uc332eni.1 uc332eni.1 
ENSMUST00000259054.1 ENSMUSG00000123572 ENSMUST00000259054.1 ENSMUSG00000123572 (from geneSymbol) uc332enj.1 uc332enj.1 
ENSMUST00000259056.1 ENSMUSG00000123573 ENSMUST00000259056.1 ENSMUSG00000123573 (from geneSymbol) uc332enl.1 uc332enl.1 
ENSMUST00000259057.1 ENSMUSG00000123574 ENSMUST00000259057.1 ENSMUSG00000123574 (from geneSymbol) uc332enm.1 uc332enm.1 
ENSMUST00000259058.1 ENSMUSG00000123575 ENSMUST00000259058.1 ENSMUSG00000123575 (from geneSymbol) uc332enn.1 uc332enn.1 
ENSMUST00000259060.1 ENSMUSG00000123576 ENSMUST00000259060.1 ENSMUSG00000123576 (from geneSymbol) uc332eno.1 uc332eno.1 
ENSMUST00000259061.1 ENSMUSG00000123577 ENSMUST00000259061.1 ENSMUSG00000123577 (from geneSymbol) uc332enp.1 uc332enp.1 
ENSMUST00000259064.1 ENSMUSG00000123578 ENSMUST00000259064.1 ENSMUSG00000123578 (from geneSymbol) uc332ens.1 uc332ens.1 
ENSMUST00000259065.1 ENSMUSG00000123579 ENSMUST00000259065.1 ENSMUSG00000123579 (from geneSymbol) uc332ent.1 uc332ent.1 
ENSMUST00000259066.1 ENSMUSG00000123580 ENSMUST00000259066.1 ENSMUSG00000123580 (from geneSymbol) uc332enu.1 uc332enu.1 
ENSMUST00000259069.1 ENSMUSG00000123581 ENSMUST00000259069.1 ENSMUSG00000123581 (from geneSymbol) uc332enx.1 uc332enx.1 
ENSMUST00000259075.1 ENSMUSG00000123582 ENSMUST00000259075.1 ENSMUSG00000123582 (from geneSymbol) uc332eod.1 uc332eod.1 
ENSMUST00000259078.1 ENSMUSG00000123583 ENSMUST00000259078.1 ENSMUSG00000123583 (from geneSymbol) uc332eog.1 uc332eog.1 
ENSMUST00000259091.1 ENSMUSG00000123584 ENSMUST00000259091.1 ENSMUSG00000123584 (from geneSymbol) AK054071 uc332eos.1 uc332eos.1 
ENSMUST00000259092.1 ENSMUSG00000123585 ENSMUST00000259092.1 ENSMUSG00000123585 (from geneSymbol) uc332eot.1 uc332eot.1 
ENSMUST00000259095.1 ENSMUSG00000123586 ENSMUST00000259095.1 ENSMUSG00000123586 (from geneSymbol) uc332eow.1 uc332eow.1 
ENSMUST00000259096.1 ENSMUSG00000123587 ENSMUST00000259096.1 ENSMUSG00000123587 (from geneSymbol) uc332eox.1 uc332eox.1 
ENSMUST00000259101.1 6330420H09Rik ENSMUST00000259101.1 6330420H09Rik (from geneSymbol) AK031861 uc332epb.1 uc332epb.1 
ENSMUST00000259104.1 ENSMUSG00000123588 ENSMUST00000259104.1 ENSMUSG00000123588 (from geneSymbol) uc332epe.1 uc332epe.1 
ENSMUST00000259113.1 ENSMUSG00000123589 ENSMUST00000259113.1 ENSMUSG00000123589 (from geneSymbol) uc332epn.1 uc332epn.1 
ENSMUST00000259114.1 Gm33035 ENSMUST00000259114.1 Gm33035 (from geneSymbol) AK135793 uc332epo.1 uc332epo.1 
ENSMUST00000259126.1 ENSMUSG00000123590 ENSMUST00000259126.1 ENSMUSG00000123590 (from geneSymbol) uc332eqa.1 uc332eqa.1 
ENSMUST00000259131.1 ENSMUSG00000123591 ENSMUST00000259131.1 ENSMUSG00000123591 (from geneSymbol) uc332eqf.1 uc332eqf.1 
ENSMUST00000259132.1 ENSMUSG00000123592 ENSMUST00000259132.1 ENSMUSG00000123592 (from geneSymbol) uc332eqg.1 uc332eqg.1 
ENSMUST00000259133.1 ENSMUSG00000123593 ENSMUST00000259133.1 ENSMUSG00000123593 (from geneSymbol) uc332eqh.1 uc332eqh.1 
ENSMUST00000259138.1 ENSMUSG00000123594 ENSMUST00000259138.1 ENSMUSG00000123594 (from geneSymbol) uc332eqm.1 uc332eqm.1 
ENSMUST00000259141.1 ENSMUSG00000123595 ENSMUST00000259141.1 ENSMUSG00000123595 (from geneSymbol) uc332eqp.1 uc332eqp.1 
ENSMUST00000259143.1 ENSMUSG00000123596 ENSMUST00000259143.1 ENSMUSG00000123596 (from geneSymbol) uc332eqr.1 uc332eqr.1 
ENSMUST00000259144.1 ENSMUSG00000123597 ENSMUST00000259144.1 ENSMUSG00000123597 (from geneSymbol) uc332eqs.1 uc332eqs.1 
ENSMUST00000259145.1 ENSMUSG00000123598 ENSMUST00000259145.1 ENSMUSG00000123598 (from geneSymbol) uc332eqt.1 uc332eqt.1 
ENSMUST00000259146.1 Gm16984 ENSMUST00000259146.1 Gm16984 (from geneSymbol) uc332equ.1 uc332equ.1 
ENSMUST00000259156.1 ENSMUSG00000123599 ENSMUST00000259156.1 ENSMUSG00000123599 (from geneSymbol) uc332ere.1 uc332ere.1 
ENSMUST00000259159.1 ENSMUSG00000123600 ENSMUST00000259159.1 ENSMUSG00000123600 (from geneSymbol) uc332erh.1 uc332erh.1 
ENSMUST00000259162.1 ENSMUSG00000123601 ENSMUST00000259162.1 ENSMUSG00000123601 (from geneSymbol) uc332erk.1 uc332erk.1 
ENSMUST00000259167.1 ENSMUSG00000123602 ENSMUST00000259167.1 ENSMUSG00000123602 (from geneSymbol) uc332erp.1 uc332erp.1 
ENSMUST00000259168.1 ENSMUSG00000123603 ENSMUST00000259168.1 ENSMUSG00000123603 (from geneSymbol) uc332erq.1 uc332erq.1 
ENSMUST00000259169.1 ENSMUSG00000123604 ENSMUST00000259169.1 ENSMUSG00000123604 (from geneSymbol) uc332err.1 uc332err.1 
ENSMUST00000259172.1 ENSMUSG00000123605 ENSMUST00000259172.1 ENSMUSG00000123605 (from geneSymbol) uc332eru.1 uc332eru.1 
ENSMUST00000259173.1 ENSMUSG00000123606 ENSMUST00000259173.1 ENSMUSG00000123606 (from geneSymbol) uc332erv.1 uc332erv.1 
ENSMUST00000259174.1 ENSMUSG00000123607 ENSMUST00000259174.1 ENSMUSG00000123607 (from geneSymbol) uc332erw.1 uc332erw.1 
ENSMUST00000259175.1 ENSMUSG00000123608 ENSMUST00000259175.1 ENSMUSG00000123608 (from geneSymbol) uc332erx.1 uc332erx.1 
ENSMUST00000259176.1 ENSMUSG00000123609 ENSMUST00000259176.1 ENSMUSG00000123609 (from geneSymbol) uc332ery.1 uc332ery.1 
ENSMUST00000259177.1 ENSMUSG00000123610 ENSMUST00000259177.1 ENSMUSG00000123610 (from geneSymbol) uc332erz.1 uc332erz.1 
ENSMUST00000259178.1 ENSMUSG00000123611 ENSMUST00000259178.1 ENSMUSG00000123611 (from geneSymbol) uc332esa.1 uc332esa.1 
ENSMUST00000259179.1 ENSMUSG00000123612 ENSMUST00000259179.1 ENSMUSG00000123612 (from geneSymbol) uc332esb.1 uc332esb.1 
ENSMUST00000259180.1 ENSMUSG00000123613 ENSMUST00000259180.1 ENSMUSG00000123613 (from geneSymbol) uc332esc.1 uc332esc.1 
ENSMUST00000259181.1 ENSMUSG00000123614 ENSMUST00000259181.1 ENSMUSG00000123614 (from geneSymbol) uc332esd.1 uc332esd.1 
ENSMUST00000259183.1 ENSMUSG00000123615 ENSMUST00000259183.1 ENSMUSG00000123615 (from geneSymbol) uc332esf.1 uc332esf.1 
ENSMUST00000259184.1 ENSMUSG00000123616 ENSMUST00000259184.1 ENSMUSG00000123616 (from geneSymbol) uc332esg.1 uc332esg.1 
ENSMUST00000259190.1 Gm56783 ENSMUST00000259190.1 Gm56783 (from geneSymbol) uc332esm.1 uc332esm.1 
ENSMUST00000259191.1 ENSMUSG00000123617 ENSMUST00000259191.1 ENSMUSG00000123617 (from geneSymbol) uc332esn.1 uc332esn.1 
ENSMUST00000259192.1 ENSMUSG00000123618 ENSMUST00000259192.1 ENSMUSG00000123618 (from geneSymbol) uc332eso.1 uc332eso.1 
ENSMUST00000259215.1 Gm5544 ENSMUST00000259215.1 Gm5544 (from geneSymbol) AK142329 uc332etk.1 uc332etk.1 
ENSMUST00000259219.1 ENSMUSG00000123619 ENSMUST00000259219.1 ENSMUSG00000123619 (from geneSymbol) uc332eto.1 uc332eto.1 
ENSMUST00000259220.1 ENSMUSG00000123620 ENSMUST00000259220.1 ENSMUSG00000123620 (from geneSymbol) uc332etp.1 uc332etp.1 
ENSMUST00000259223.1 ENSMUSG00000123621 ENSMUST00000259223.1 ENSMUSG00000123621 (from geneSymbol) AK015649 uc332ets.1 uc332ets.1 
ENSMUST00000259227.1 ENSMUSG00000123622 ENSMUST00000259227.1 ENSMUSG00000123622 (from geneSymbol) uc332etw.1 uc332etw.1 
ENSMUST00000259234.1 ENSMUSG00000123623 ENSMUST00000259234.1 ENSMUSG00000123623 (from geneSymbol) uc332eud.1 uc332eud.1 
ENSMUST00000259235.1 ENSMUSG00000123624 ENSMUST00000259235.1 ENSMUSG00000123624 (from geneSymbol) uc332eue.1 uc332eue.1 
ENSMUST00000259237.1 ENSMUSG00000123626 ENSMUST00000259237.1 ENSMUSG00000123626 (from geneSymbol) uc332euf.1 uc332euf.1 
ENSMUST00000259240.1 ENSMUSG00000123627 ENSMUST00000259240.1 ENSMUSG00000123627 (from geneSymbol) uc332eui.1 uc332eui.1 
ENSMUST00000259241.1 ENSMUSG00000123628 ENSMUST00000259241.1 ENSMUSG00000123628 (from geneSymbol) uc332euj.1 uc332euj.1 
ENSMUST00000259243.1 ENSMUSG00000123629 ENSMUST00000259243.1 ENSMUSG00000123629 (from geneSymbol) AK133183 uc332eul.1 uc332eul.1 
ENSMUST00000259249.1 Gm15270 ENSMUST00000259249.1 predicted gene 15270 (from RefSeq NR_163910.1) NR_163910 uc332eur.1 uc332eur.1 
ENSMUST00000259295.1 ENSMUSG00000123630 ENSMUST00000259295.1 ENSMUSG00000123630 (from geneSymbol) uc332ewk.1 uc332ewk.1 
ENSMUST00000259296.1 ENSMUSG00000123631 ENSMUST00000259296.1 ENSMUSG00000123631 (from geneSymbol) uc332ewl.1 uc332ewl.1 
ENSMUST00000259297.1 ENSMUSG00000123632 ENSMUST00000259297.1 ENSMUSG00000123632 (from geneSymbol) uc332ewm.1 uc332ewm.1 
ENSMUST00000259298.1 ENSMUSG00000123633 ENSMUST00000259298.1 ENSMUSG00000123633 (from geneSymbol) uc332ewn.1 uc332ewn.1 
ENSMUST00000259301.1 ENSMUSG00000123634 ENSMUST00000259301.1 ENSMUSG00000123634 (from geneSymbol) uc332ewq.1 uc332ewq.1 
ENSMUST00000259303.1 ENSMUSG00000123636 ENSMUST00000259303.1 ENSMUSG00000123636 (from geneSymbol) uc332ewr.1 uc332ewr.1 
ENSMUST00000259311.1 ENSMUSG00000123637 ENSMUST00000259311.1 ENSMUSG00000123637 (from geneSymbol) LF201231 uc332ewz.1 uc332ewz.1 
ENSMUST00000259312.1 ENSMUSG00000123638 ENSMUST00000259312.1 ENSMUSG00000123638 (from geneSymbol) uc332exa.1 uc332exa.1 
ENSMUST00000259315.1 ENSMUSG00000123639 ENSMUST00000259315.1 ENSMUSG00000123639 (from geneSymbol) uc332exd.1 uc332exd.1 
ENSMUST00000259316.1 Gm57385 ENSMUST00000259316.1 Gm57385 (from geneSymbol) AK140192 uc332exe.1 uc332exe.1 
ENSMUST00000259318.1 ENSMUSG00000123640 ENSMUST00000259318.1 ENSMUSG00000123640 (from geneSymbol) uc332exg.1 uc332exg.1 
ENSMUST00000259320.1 ENSMUSG00000123641 ENSMUST00000259320.1 ENSMUSG00000123641 (from geneSymbol) uc332exi.1 uc332exi.1 
ENSMUST00000259321.1 ENSMUSG00000123642 ENSMUST00000259321.1 ENSMUSG00000123642 (from geneSymbol) uc332exj.1 uc332exj.1 
ENSMUST00000259324.1 ENSMUSG00000123643 ENSMUST00000259324.1 ENSMUSG00000123643 (from geneSymbol) uc332exm.1 uc332exm.1 
ENSMUST00000259326.1 ENSMUSG00000123644 ENSMUST00000259326.1 ENSMUSG00000123644 (from geneSymbol) uc332exo.1 uc332exo.1 
ENSMUST00000259345.1 ENSMUSG00000123645 ENSMUST00000259345.1 ENSMUSG00000123645 (from geneSymbol) uc332eyh.1 uc332eyh.1 
ENSMUST00000259347.1 ENSMUSG00000123646 ENSMUST00000259347.1 ENSMUSG00000123646 (from geneSymbol) uc332eyj.1 uc332eyj.1 
ENSMUST00000259352.1 ENSMUSG00000123647 ENSMUST00000259352.1 ENSMUSG00000123647 (from geneSymbol) uc332eyn.1 uc332eyn.1 
ENSMUST00000259362.1 ENSMUSG00000123649 ENSMUST00000259362.1 ENSMUSG00000123649 (from geneSymbol) uc332eyu.1 uc332eyu.1 
ENSMUST00000259374.1 ENSMUSG00000123650 ENSMUST00000259374.1 ENSMUSG00000123650 (from geneSymbol) uc332ezg.1 uc332ezg.1 
ENSMUST00000259382.1 ENSMUSG00000123651 ENSMUST00000259382.1 ENSMUSG00000123651 (from geneSymbol) uc332ezo.1 uc332ezo.1 
ENSMUST00000259383.1 6030442E23Rik ENSMUST00000259383.1 6030442E23Rik (from geneSymbol) AK020061 uc332ezp.1 uc332ezp.1 
ENSMUST00000259384.1 ENSMUSG00000123652 ENSMUST00000259384.1 ENSMUSG00000123652 (from geneSymbol) uc332ezq.1 uc332ezq.1 
ENSMUST00000259385.1 1700016A09Rik ENSMUST00000259385.1 RIKEN cDNA 1700016A09 gene (from RefSeq NR_151732.1) NR_151732 uc332ezr.1 uc332ezr.1 
ENSMUST00000259386.1 ENSMUSG00000123654 ENSMUST00000259386.1 ENSMUSG00000123654 (from geneSymbol) uc332ezs.1 uc332ezs.1 
ENSMUST00000259387.1 Fendrr ENSMUST00000259387.1 Fendrr (from geneSymbol) JQ973641 uc332ezt.1 uc332ezt.1 
ENSMUST00000259388.1 ENSMUSG00000123655 ENSMUST00000259388.1 ENSMUSG00000123655 (from geneSymbol) uc332ezu.1 uc332ezu.1 
ENSMUST00000259389.1 ENSMUSG00000123656 ENSMUST00000259389.1 ENSMUSG00000123656 (from geneSymbol) uc332ezv.1 uc332ezv.1 
ENSMUST00000259391.1 ENSMUSG00000123657 ENSMUST00000259391.1 ENSMUSG00000123657 (from geneSymbol) uc332ezx.1 uc332ezx.1 
ENSMUST00000259393.1 ENSMUSG00000123658 ENSMUST00000259393.1 ENSMUSG00000123658 (from geneSymbol) uc332ezz.1 uc332ezz.1 
ENSMUST00000259396.1 ENSMUSG00000123659 ENSMUST00000259396.1 ENSMUSG00000123659 (from geneSymbol) uc332fac.1 uc332fac.1 
ENSMUST00000259398.1 ENSMUSG00000123660 ENSMUST00000259398.1 ENSMUSG00000123660 (from geneSymbol) uc332fae.1 uc332fae.1 
ENSMUST00000259400.1 ENSMUSG00000123661 ENSMUST00000259400.1 ENSMUSG00000123661 (from geneSymbol) uc332fag.1 uc332fag.1 
ENSMUST00000259404.1 ENSMUSG00000123662 ENSMUST00000259404.1 ENSMUSG00000123662 (from geneSymbol) uc332fak.1 uc332fak.1 
ENSMUST00000259408.1 ENSMUSG00000123663 ENSMUST00000259408.1 ENSMUSG00000123663 (from geneSymbol) uc332fao.1 uc332fao.1 
ENSMUST00000259409.1 ENSMUSG00000123664 ENSMUST00000259409.1 ENSMUSG00000123664 (from geneSymbol) uc332fap.1 uc332fap.1 
ENSMUST00000259411.1 ENSMUSG00000123665 ENSMUST00000259411.1 ENSMUSG00000123665 (from geneSymbol) uc332far.1 uc332far.1 
ENSMUST00000259413.1 ENSMUSG00000123666 ENSMUST00000259413.1 ENSMUSG00000123666 (from geneSymbol) uc332fat.1 uc332fat.1 
ENSMUST00000259416.1 ENSMUSG00000123667 ENSMUST00000259416.1 ENSMUSG00000123667 (from geneSymbol) uc332faw.1 uc332faw.1 
ENSMUST00000259418.1 ENSMUSG00000123668 ENSMUST00000259418.1 ENSMUSG00000123668 (from geneSymbol) uc332fay.1 uc332fay.1 
ENSMUST00000259421.1 ENSMUSG00000123669 ENSMUST00000259421.1 ENSMUSG00000123669 (from geneSymbol) uc332fbb.1 uc332fbb.1 
ENSMUST00000259441.1 ENSMUSG00000123670 ENSMUST00000259441.1 ENSMUSG00000123670 (from geneSymbol) uc332fbv.1 uc332fbv.1 
ENSMUST00000259450.1 ENSMUSG00000123671 ENSMUST00000259450.1 ENSMUSG00000123671 (from geneSymbol) uc332fce.1 uc332fce.1 
ENSMUST00000259452.1 ENSMUSG00000123672 ENSMUST00000259452.1 ENSMUSG00000123672 (from geneSymbol) uc332fcg.1 uc332fcg.1 
ENSMUST00000259456.1 ENSMUSG00000123673 ENSMUST00000259456.1 ENSMUSG00000123673 (from geneSymbol) uc332fck.1 uc332fck.1 
ENSMUST00000259457.1 ENSMUSG00000123674 ENSMUST00000259457.1 ENSMUSG00000123674 (from geneSymbol) uc332fcl.1 uc332fcl.1 
ENSMUST00000259460.1 ENSMUSG00000123675 ENSMUST00000259460.1 ENSMUSG00000123675 (from geneSymbol) uc332fco.1 uc332fco.1 
ENSMUST00000259462.1 Gm21469 ENSMUST00000259462.1 Gm21469 (from geneSymbol) uc332fcq.1 uc332fcq.1 
ENSMUST00000259466.1 ENSMUSG00000123677 ENSMUST00000259466.1 ENSMUSG00000123677 (from geneSymbol) uc332fcu.1 uc332fcu.1 
ENSMUST00000259474.1 Gm57393 ENSMUST00000259474.1 Gm57393 (from geneSymbol) uc332fdb.1 uc332fdb.1 
ENSMUST00000259475.1 ENSMUSG00000123678 ENSMUST00000259475.1 ENSMUSG00000123678 (from geneSymbol) uc332fdc.1 uc332fdc.1 
ENSMUST00000259477.1 Gm5112 ENSMUST00000259477.1 predicted gene 5112 (from RefSeq NR_190046.1) NR_190046 uc332fde.1 uc332fde.1 
ENSMUST00000259478.1 ENSMUSG00000123680 ENSMUST00000259478.1 ENSMUSG00000123680 (from geneSymbol) uc332fdf.1 uc332fdf.1 
ENSMUST00000259479.1 ENSMUSG00000123681 ENSMUST00000259479.1 ENSMUSG00000123681 (from geneSymbol) uc332fdg.1 uc332fdg.1 
ENSMUST00000259483.1 ENSMUSG00000123682 ENSMUST00000259483.1 ENSMUSG00000123682 (from geneSymbol) uc332fdk.1 uc332fdk.1 
ENSMUST00000259489.1 ENSMUSG00000123683 ENSMUST00000259489.1 ENSMUSG00000123683 (from geneSymbol) uc332fdq.1 uc332fdq.1 
ENSMUST00000259491.1 1700026D11Rik ENSMUST00000259491.1 1700026D11Rik (from geneSymbol) AK006376 uc332fds.1 uc332fds.1 
ENSMUST00000259538.1 ENSMUSG00000123684 ENSMUST00000259538.1 ENSMUSG00000123684 (from geneSymbol) uc332ffn.1 uc332ffn.1 
ENSMUST00000259543.1 4930417H01Rik ENSMUST00000259543.1 4930417H01Rik (from geneSymbol) AK144823 uc332ffs.1 uc332ffs.1 
ENSMUST00000259617.1 ENSMUSG00000123685 ENSMUST00000259617.1 ENSMUSG00000123685 (from geneSymbol) uc332fio.1 uc332fio.1 
ENSMUST00000259619.1 ENSMUSG00000123686 ENSMUST00000259619.1 ENSMUSG00000123686 (from geneSymbol) uc332fiq.1 uc332fiq.1 
ENSMUST00000259621.1 ENSMUSG00000123687 ENSMUST00000259621.1 ENSMUSG00000123687 (from geneSymbol) uc332fis.1 uc332fis.1 
ENSMUST00000259628.1 ENSMUSG00000123688 ENSMUST00000259628.1 ENSMUSG00000123688 (from geneSymbol) uc332fiz.1 uc332fiz.1 
ENSMUST00000259629.1 ENSMUSG00000123689 ENSMUST00000259629.1 ENSMUSG00000123689 (from geneSymbol) uc332fja.1 uc332fja.1 
ENSMUST00000259631.1 ENSMUSG00000123690 ENSMUST00000259631.1 ENSMUSG00000123690 (from geneSymbol) uc332fjc.1 uc332fjc.1 
ENSMUST00000259632.1 ENSMUSG00000123691 ENSMUST00000259632.1 ENSMUSG00000123691 (from geneSymbol) uc332fjd.1 uc332fjd.1 
ENSMUST00000259636.1 ENSMUSG00000123692 ENSMUST00000259636.1 ENSMUSG00000123692 (from geneSymbol) uc332fjg.1 uc332fjg.1 
ENSMUST00000259640.1 ENSMUSG00000123693 ENSMUST00000259640.1 ENSMUSG00000123693 (from geneSymbol) uc332fjk.1 uc332fjk.1 
ENSMUST00000259642.1 Gm16541 ENSMUST00000259642.1 Gm16541 (from geneSymbol) AK006610 uc332fjm.1 uc332fjm.1 
ENSMUST00000259651.1 Gm26679 ENSMUST00000259651.1 Gm26679 (from geneSymbol) AK083202 uc332fju.1 uc332fju.1 
ENSMUST00000259652.1 ENSMUSG00000123695 ENSMUST00000259652.1 ENSMUSG00000123695 (from geneSymbol) uc332fjv.1 uc332fjv.1 
ENSMUST00000259655.1 ENSMUSG00000123696 ENSMUST00000259655.1 ENSMUSG00000123696 (from geneSymbol) uc332fjy.1 uc332fjy.1 
ENSMUST00000259666.1 ENSMUSG00000123697 ENSMUST00000259666.1 ENSMUSG00000123697 (from geneSymbol) uc332fkj.1 uc332fkj.1 
ENSMUST00000259667.1 ENSMUSG00000123698 ENSMUST00000259667.1 ENSMUSG00000123698 (from geneSymbol) uc332fkk.1 uc332fkk.1 
ENSMUST00000259670.1 ENSMUSG00000123699 ENSMUST00000259670.1 ENSMUSG00000123699 (from geneSymbol) uc332fkn.1 uc332fkn.1 
ENSMUST00000259675.1 ENSMUSG00000123700 ENSMUST00000259675.1 ENSMUSG00000123700 (from geneSymbol) uc332fks.1 uc332fks.1 
ENSMUST00000259677.1 ENSMUSG00000123701 ENSMUST00000259677.1 ENSMUSG00000123701 (from geneSymbol) uc332fku.1 uc332fku.1 
ENSMUST00000259679.1 ENSMUSG00000123702 ENSMUST00000259679.1 ENSMUSG00000123702 (from geneSymbol) uc332fkw.1 uc332fkw.1 
ENSMUST00000259680.1 ENSMUSG00000123703 ENSMUST00000259680.1 ENSMUSG00000123703 (from geneSymbol) uc332fkx.1 uc332fkx.1 
ENSMUST00000259681.1 ENSMUSG00000123704 ENSMUST00000259681.1 ENSMUSG00000123704 (from geneSymbol) uc332fky.1 uc332fky.1 
ENSMUST00000259682.1 Gm56776 ENSMUST00000259682.1 Gm56776 (from geneSymbol) uc332fkz.1 uc332fkz.1 
ENSMUST00000259683.1 ENSMUSG00000123705 ENSMUST00000259683.1 ENSMUSG00000123705 (from geneSymbol) uc332fla.1 uc332fla.1 
ENSMUST00000259684.1 ENSMUSG00000123706 ENSMUST00000259684.1 ENSMUSG00000123706 (from geneSymbol) uc332flb.1 uc332flb.1 
ENSMUST00000259686.1 Gm57333 ENSMUST00000259686.1 Gm57333 (from geneSymbol) uc332fld.1 uc332fld.1 
ENSMUST00000259702.1 ENSMUSG00000123707 ENSMUST00000259702.1 ENSMUSG00000123707 (from geneSymbol) uc332flt.1 uc332flt.1 
ENSMUST00000259703.1 Gm14966 ENSMUST00000259703.1 Gm14966 (from geneSymbol) uc332flu.1 uc332flu.1 
ENSMUST00000259715.1 ENSMUSG00000123708 ENSMUST00000259715.1 ENSMUSG00000123708 (from geneSymbol) uc332fmd.1 uc332fmd.1 
ENSMUST00000259722.1 ENSMUSG00000123709 ENSMUST00000259722.1 ENSMUSG00000123709 (from geneSymbol) uc332fmj.1 uc332fmj.1 
ENSMUST00000259753.1 ENSMUSG00000123710 ENSMUST00000259753.1 ENSMUSG00000123710 (from geneSymbol) uc332fno.1 uc332fno.1 
ENSMUST00000259759.1 ENSMUSG00000123711 ENSMUST00000259759.1 ENSMUSG00000123711 (from geneSymbol) uc332fnu.1 uc332fnu.1 
ENSMUST00000259763.1 Gm36328 ENSMUST00000259763.1 Gm36328 (from geneSymbol) AK006793 uc332fny.1 uc332fny.1 
ENSMUST00000259770.1 ENSMUSG00000123712 ENSMUST00000259770.1 ENSMUSG00000123712 (from geneSymbol) uc332fof.1 uc332fof.1 
ENSMUST00000259772.1 ENSMUSG00000123713 ENSMUST00000259772.1 ENSMUSG00000123713 (from geneSymbol) uc332foh.1 uc332foh.1 
ENSMUST00000259773.1 ENSMUSG00000123714 ENSMUST00000259773.1 ENSMUSG00000123714 (from geneSymbol) uc332foi.1 uc332foi.1 
ENSMUST00000259775.1 ENSMUSG00000123715 ENSMUST00000259775.1 ENSMUSG00000123715 (from geneSymbol) uc332fok.1 uc332fok.1 
ENSMUST00000259779.1 Gm15271 ENSMUST00000259779.1 Gm15271 (from geneSymbol) uc332foo.1 uc332foo.1 
ENSMUST00000259780.1 ENSMUSG00000123716 ENSMUST00000259780.1 ENSMUSG00000123716 (from geneSymbol) uc332fop.1 uc332fop.1 
ENSMUST00000259781.1 ENSMUSG00000123717 ENSMUST00000259781.1 ENSMUSG00000123717 (from geneSymbol) uc332foq.1 uc332foq.1 
ENSMUST00000259782.1 1700007P06Rik ENSMUST00000259782.1 1700007P06Rik (from geneSymbol) AK005744 uc332for.1 uc332for.1 
ENSMUST00000259787.1 ENSMUSG00000123718 ENSMUST00000259787.1 ENSMUSG00000123718 (from geneSymbol) uc332fow.1 uc332fow.1 
ENSMUST00000259788.1 ENSMUSG00000123719 ENSMUST00000259788.1 ENSMUSG00000123719 (from geneSymbol) uc332fox.1 uc332fox.1 
ENSMUST00000259789.1 ENSMUSG00000123720 ENSMUST00000259789.1 ENSMUSG00000123720 (from geneSymbol) uc332foy.1 uc332foy.1 
ENSMUST00000259793.1 ENSMUSG00000123721 ENSMUST00000259793.1 ENSMUSG00000123721 (from geneSymbol) uc332fpc.1 uc332fpc.1 
ENSMUST00000259796.1 ENSMUSG00000123722 ENSMUST00000259796.1 ENSMUSG00000123722 (from geneSymbol) uc332fpf.1 uc332fpf.1 
ENSMUST00000259802.1 ENSMUSG00000123723 ENSMUST00000259802.1 ENSMUSG00000123723 (from geneSymbol) uc332fpl.1 uc332fpl.1 
ENSMUST00000259810.1 ENSMUSG00000123724 ENSMUST00000259810.1 ENSMUSG00000123724 (from geneSymbol) uc332fpt.1 uc332fpt.1 
ENSMUST00000259811.1 ENSMUSG00000123725 ENSMUST00000259811.1 ENSMUSG00000123725 (from geneSymbol) uc332fpu.1 uc332fpu.1 
ENSMUST00000259858.1 ENSMUSG00000123726 ENSMUST00000259858.1 ENSMUSG00000123726 (from geneSymbol) uc332frm.1 uc332frm.1 
ENSMUST00000259860.1 ENSMUSG00000123727 ENSMUST00000259860.1 ENSMUSG00000123727 (from geneSymbol) uc332fro.1 uc332fro.1 
ENSMUST00000259863.1 ENSMUSG00000123728 ENSMUST00000259863.1 ENSMUSG00000123728 (from geneSymbol) uc332frr.1 uc332frr.1 
ENSMUST00000259864.1 ENSMUSG00000123729 ENSMUST00000259864.1 ENSMUSG00000123729 (from geneSymbol) uc332frs.1 uc332frs.1 
ENSMUST00000259865.1 ENSMUSG00000123730 ENSMUST00000259865.1 ENSMUSG00000123730 (from geneSymbol) uc332frt.1 uc332frt.1 
ENSMUST00000259873.1 Bloc1s6os ENSMUST00000259873.1 Bloc1s6os (from geneSymbol) uc332fsb.1 uc332fsb.1 
ENSMUST00000259878.1 ENSMUSG00000123731 ENSMUST00000259878.1 ENSMUSG00000123731 (from geneSymbol) uc332fsg.1 uc332fsg.1 
ENSMUST00000259880.1 Gm56511 ENSMUST00000259880.1 Gm56511 (from geneSymbol) uc332fsi.1 uc332fsi.1 
ENSMUST00000259885.1 ENSMUSG00000123732 ENSMUST00000259885.1 ENSMUSG00000123732 (from geneSymbol) uc332fsn.1 uc332fsn.1 
ENSMUST00000259886.1 ENSMUSG00000123733 ENSMUST00000259886.1 ENSMUSG00000123733 (from geneSymbol) uc332fso.1 uc332fso.1 
ENSMUST00000259889.1 ENSMUSG00000123734 ENSMUST00000259889.1 ENSMUSG00000123734 (from geneSymbol) uc332fsr.1 uc332fsr.1 
ENSMUST00000259896.1 ENSMUSG00000123735 ENSMUST00000259896.1 ENSMUSG00000123735 (from geneSymbol) uc332fsy.1 uc332fsy.1 
ENSMUST00000259897.1 ENSMUSG00000123736 ENSMUST00000259897.1 ENSMUSG00000123736 (from geneSymbol) uc332fsz.1 uc332fsz.1 
ENSMUST00000259898.1 ENSMUSG00000123737 ENSMUST00000259898.1 ENSMUSG00000123737 (from geneSymbol) uc332fta.1 uc332fta.1 
ENSMUST00000259899.1 ENSMUSG00000123738 ENSMUST00000259899.1 ENSMUSG00000123738 (from geneSymbol) uc332ftb.1 uc332ftb.1 
ENSMUST00000259900.1 ENSMUSG00000123739 ENSMUST00000259900.1 ENSMUSG00000123739 (from geneSymbol) uc332ftc.1 uc332ftc.1 
ENSMUST00000259901.1 ENSMUSG00000123740 ENSMUST00000259901.1 ENSMUSG00000123740 (from geneSymbol) uc332ftd.1 uc332ftd.1 
ENSMUST00000259902.1 ENSMUSG00000123741 ENSMUST00000259902.1 ENSMUSG00000123741 (from geneSymbol) uc332fte.1 uc332fte.1 
ENSMUST00000259903.1 ENSMUSG00000123742 ENSMUST00000259903.1 ENSMUSG00000123742 (from geneSymbol) uc332ftf.1 uc332ftf.1 
ENSMUST00000259904.1 ENSMUSG00000123743 ENSMUST00000259904.1 ENSMUSG00000123743 (from geneSymbol) uc332ftg.1 uc332ftg.1 
ENSMUST00000259906.1 ENSMUSG00000123744 ENSMUST00000259906.1 ENSMUSG00000123744 (from geneSymbol) uc332fti.1 uc332fti.1 
ENSMUST00000259911.1 ENSMUSG00000123745 ENSMUST00000259911.1 ENSMUSG00000123745 (from geneSymbol) uc332ftn.1 uc332ftn.1 
ENSMUST00000259915.1 ENSMUSG00000123746 ENSMUST00000259915.1 ENSMUSG00000123746 (from geneSymbol) uc332ftr.1 uc332ftr.1 
ENSMUST00000259918.1 ENSMUSG00000123747 ENSMUST00000259918.1 ENSMUSG00000123747 (from geneSymbol) uc332ftu.1 uc332ftu.1 
ENSMUST00000259919.1 ENSMUSG00000123748 ENSMUST00000259919.1 ENSMUSG00000123748 (from geneSymbol) uc332ftv.1 uc332ftv.1 
ENSMUST00000259920.1 ENSMUSG00000123749 ENSMUST00000259920.1 ENSMUSG00000123749 (from geneSymbol) uc332ftw.1 uc332ftw.1 
ENSMUST00000259934.1 ENSMUSG00000123750 ENSMUST00000259934.1 ENSMUSG00000123750 (from geneSymbol) uc332fuk.1 uc332fuk.1 
ENSMUST00000259936.1 ENSMUSG00000123751 ENSMUST00000259936.1 ENSMUSG00000123751 (from geneSymbol) uc332fum.1 uc332fum.1 
ENSMUST00000259946.1 Gm41750 ENSMUST00000259946.1 Gm41750 (from geneSymbol) uc332fuw.1 uc332fuw.1 
ENSMUST00000259987.1 ENSMUSG00000123752 ENSMUST00000259987.1 ENSMUSG00000123752 (from geneSymbol) uc332fwl.1 uc332fwl.1 
ENSMUST00000259988.1 Gm49722 ENSMUST00000259988.1 Gm49722 (from geneSymbol) uc332fwm.1 uc332fwm.1 
ENSMUST00000259989.1 ENSMUSG00000123753 ENSMUST00000259989.1 ENSMUSG00000123753 (from geneSymbol) uc332fwn.1 uc332fwn.1 
ENSMUST00000259993.1 ENSMUSG00000123754 ENSMUST00000259993.1 ENSMUSG00000123754 (from geneSymbol) uc332fwr.1 uc332fwr.1 
ENSMUST00000260000.1 ENSMUSG00000123755 ENSMUST00000260000.1 ENSMUSG00000123755 (from geneSymbol) uc332fwy.1 uc332fwy.1 
ENSMUST00000260011.1 ENSMUSG00000123756 ENSMUST00000260011.1 ENSMUSG00000123756 (from geneSymbol) uc332fxj.1 uc332fxj.1 
ENSMUST00000260021.1 ENSMUSG00000123757 ENSMUST00000260021.1 ENSMUSG00000123757 (from geneSymbol) uc332fxt.1 uc332fxt.1 
ENSMUST00000260022.1 ENSMUSG00000123758 ENSMUST00000260022.1 ENSMUSG00000123758 (from geneSymbol) uc332fxu.1 uc332fxu.1 
ENSMUST00000260029.1 ENSMUSG00000123759 ENSMUST00000260029.1 ENSMUSG00000123759 (from geneSymbol) uc332fyb.1 uc332fyb.1 
ENSMUST00000260031.1 ENSMUSG00000123760 ENSMUST00000260031.1 ENSMUSG00000123760 (from geneSymbol) uc332fyd.1 uc332fyd.1 
ENSMUST00000260033.1 Gm15509 ENSMUST00000260033.1 Gm15509 (from geneSymbol) AK133047 uc332fyf.1 uc332fyf.1 
ENSMUST00000260035.1 ENSMUSG00000123761 ENSMUST00000260035.1 ENSMUSG00000123761 (from geneSymbol) uc332fyh.1 uc332fyh.1 
ENSMUST00000260036.1 ENSMUSG00000123762 ENSMUST00000260036.1 ENSMUSG00000123762 (from geneSymbol) uc332fyi.1 uc332fyi.1 
ENSMUST00000260040.1 ENSMUSG00000123763 ENSMUST00000260040.1 ENSMUSG00000123763 (from geneSymbol) AK008862 uc332fym.1 uc332fym.1 
ENSMUST00000260041.1 ENSMUSG00000123764 ENSMUST00000260041.1 ENSMUSG00000123764 (from geneSymbol) uc332fyn.1 uc332fyn.1 
ENSMUST00000260042.1 ENSMUSG00000123765 ENSMUST00000260042.1 ENSMUSG00000123765 (from geneSymbol) uc332fyo.1 uc332fyo.1 
ENSMUST00000260043.1 ENSMUSG00000123766 ENSMUST00000260043.1 ENSMUSG00000123766 (from geneSymbol) uc332fyp.1 uc332fyp.1 
ENSMUST00000260044.1 ENSMUSG00000123767 ENSMUST00000260044.1 ENSMUSG00000123767 (from geneSymbol) uc332fyq.1 uc332fyq.1 
ENSMUST00000260046.1 ENSMUSG00000123768 ENSMUST00000260046.1 ENSMUSG00000123768 (from geneSymbol) uc332fys.1 uc332fys.1 
ENSMUST00000260049.1 ENSMUSG00000123769 ENSMUST00000260049.1 ENSMUSG00000123769 (from geneSymbol) uc332fyv.1 uc332fyv.1 
ENSMUST00000260052.1 ENSMUSG00000123770 ENSMUST00000260052.1 ENSMUSG00000123770 (from geneSymbol) uc332fyy.1 uc332fyy.1 
ENSMUST00000260053.1 ENSMUSG00000123771 ENSMUST00000260053.1 ENSMUSG00000123771 (from geneSymbol) uc332fyz.1 uc332fyz.1 
ENSMUST00000260054.1 ENSMUSG00000123772 ENSMUST00000260054.1 ENSMUSG00000123772 (from geneSymbol) uc332fza.1 uc332fza.1 
ENSMUST00000260056.1 ENSMUSG00000123773 ENSMUST00000260056.1 ENSMUSG00000123773 (from geneSymbol) uc332fzc.1 uc332fzc.1 
ENSMUST00000260057.1 ENSMUSG00000123774 ENSMUST00000260057.1 ENSMUSG00000123774 (from geneSymbol) uc332fzd.1 uc332fzd.1 
ENSMUST00000260058.1 ENSMUSG00000123775 ENSMUST00000260058.1 ENSMUSG00000123775 (from geneSymbol) uc332fze.1 uc332fze.1 
ENSMUST00000260059.1 ENSMUSG00000123776 ENSMUST00000260059.1 ENSMUSG00000123776 (from geneSymbol) uc332fzf.1 uc332fzf.1 
ENSMUST00000260061.1 ENSMUSG00000123777 ENSMUST00000260061.1 ENSMUSG00000123777 (from geneSymbol) uc332fzh.1 uc332fzh.1 
ENSMUST00000260062.1 ENSMUSG00000123778 ENSMUST00000260062.1 ENSMUSG00000123778 (from geneSymbol) AK006813 uc332fzi.1 uc332fzi.1 
ENSMUST00000260063.1 ENSMUSG00000123779 ENSMUST00000260063.1 ENSMUSG00000123779 (from geneSymbol) uc332fzj.1 uc332fzj.1 
ENSMUST00000260071.1 Gm30593 ENSMUST00000260071.1 Gm30593 (from geneSymbol) uc332fzr.1 uc332fzr.1 
ENSMUST00000260090.1 ENSMUSG00000123780 ENSMUST00000260090.1 ENSMUSG00000123780 (from geneSymbol) uc332gak.1 uc332gak.1 
ENSMUST00000260091.1 ENSMUSG00000123781 ENSMUST00000260091.1 ENSMUSG00000123781 (from geneSymbol) uc332gal.1 uc332gal.1 
ENSMUST00000260096.1 ENSMUSG00000123782 ENSMUST00000260096.1 ENSMUSG00000123782 (from geneSymbol) uc332gaq.1 uc332gaq.1 
ENSMUST00000260099.1 ENSMUSG00000123783 ENSMUST00000260099.1 ENSMUSG00000123783 (from geneSymbol) uc332gat.1 uc332gat.1 
ENSMUST00000260100.1 ENSMUSG00000123784 ENSMUST00000260100.1 ENSMUSG00000123784 (from geneSymbol) uc332gau.1 uc332gau.1 
ENSMUST00000260102.1 ENSMUSG00000123785 ENSMUST00000260102.1 ENSMUSG00000123785 (from geneSymbol) uc332gaw.1 uc332gaw.1 
ENSMUST00000260103.1 ENSMUSG00000123786 ENSMUST00000260103.1 ENSMUSG00000123786 (from geneSymbol) uc332gax.1 uc332gax.1 
ENSMUST00000260107.1 ENSMUSG00000123787 ENSMUST00000260107.1 ENSMUSG00000123787 (from geneSymbol) uc332gbb.1 uc332gbb.1 
ENSMUST00000260108.1 ENSMUSG00000123788 ENSMUST00000260108.1 ENSMUSG00000123788 (from geneSymbol) uc332gbc.1 uc332gbc.1 
ENSMUST00000260109.1 ENSMUSG00000123789 ENSMUST00000260109.1 ENSMUSG00000123789 (from geneSymbol) uc332gbd.1 uc332gbd.1 
ENSMUST00000260111.1 Gm31619 ENSMUST00000260111.1 Gm31619 (from geneSymbol) uc332gbf.1 uc332gbf.1 
ENSMUST00000260114.1 ENSMUSG00000123790 ENSMUST00000260114.1 ENSMUSG00000123790 (from geneSymbol) uc332gbi.1 uc332gbi.1 
ENSMUST00000260117.1 ENSMUSG00000123791 ENSMUST00000260117.1 ENSMUSG00000123791 (from geneSymbol) uc332gbl.1 uc332gbl.1 
ENSMUST00000260121.1 ENSMUSG00000123792 ENSMUST00000260121.1 ENSMUSG00000123792 (from geneSymbol) uc332gbp.1 uc332gbp.1 
ENSMUST00000260122.1 ENSMUSG00000123793 ENSMUST00000260122.1 ENSMUSG00000123793 (from geneSymbol) uc332gbq.1 uc332gbq.1 
ENSMUST00000260123.1 ENSMUSG00000123794 ENSMUST00000260123.1 ENSMUSG00000123794 (from geneSymbol) uc332gbr.1 uc332gbr.1 
ENSMUST00000260152.1 ENSMUSG00000123795 ENSMUST00000260152.1 ENSMUSG00000123795 (from geneSymbol) uc332gcu.1 uc332gcu.1 
ENSMUST00000260155.1 2410003I16Rik ENSMUST00000260155.1 2410003I16Rik (from geneSymbol) uc332gcx.1 uc332gcx.1 
ENSMUST00000260178.1 Gm46336 ENSMUST00000260178.1 Gm46336 (from geneSymbol) uc332gdu.1 uc332gdu.1 
ENSMUST00000260179.1 ENSMUSG00000123796 ENSMUST00000260179.1 ENSMUSG00000123796 (from geneSymbol) uc332gdv.1 uc332gdv.1 
ENSMUST00000260180.1 ENSMUSG00000123797 ENSMUST00000260180.1 ENSMUSG00000123797 (from geneSymbol) uc332gdw.1 uc332gdw.1 
ENSMUST00000260181.1 ENSMUSG00000123798 ENSMUST00000260181.1 ENSMUSG00000123798 (from geneSymbol) uc332gdx.1 uc332gdx.1 
ENSMUST00000260245.1 ENSMUSG00000123799 ENSMUST00000260245.1 ENSMUSG00000123799 (from geneSymbol) uc332ggj.1 uc332ggj.1 
ENSMUST00000260247.1 ENSMUSG00000123800 ENSMUST00000260247.1 ENSMUSG00000123800 (from geneSymbol) uc332ggl.1 uc332ggl.1 
ENSMUST00000260249.1 ENSMUSG00000123801 ENSMUST00000260249.1 ENSMUSG00000123801 (from geneSymbol) uc332ggn.1 uc332ggn.1 
ENSMUST00000260250.1 ENSMUSG00000123802 ENSMUST00000260250.1 ENSMUSG00000123802 (from geneSymbol) uc332ggo.1 uc332ggo.1 
ENSMUST00000260252.1 ENSMUSG00000123803 ENSMUST00000260252.1 ENSMUSG00000123803 (from geneSymbol) uc332ggq.1 uc332ggq.1 
ENSMUST00000260253.1 ENSMUSG00000123804 ENSMUST00000260253.1 ENSMUSG00000123804 (from geneSymbol) uc332ggr.1 uc332ggr.1 
ENSMUST00000260254.1 ENSMUSG00000123805 ENSMUST00000260254.1 ENSMUSG00000123805 (from geneSymbol) uc332ggs.1 uc332ggs.1 
ENSMUST00000260271.1 ENSMUSG00000123806 ENSMUST00000260271.1 ENSMUSG00000123806 (from geneSymbol) uc332ghj.1 uc332ghj.1 
ENSMUST00000260272.1 ENSMUSG00000123807 ENSMUST00000260272.1 ENSMUSG00000123807 (from geneSymbol) uc332ghk.1 uc332ghk.1 
ENSMUST00000260280.1 ENSMUSG00000123808 ENSMUST00000260280.1 ENSMUSG00000123808 (from geneSymbol) uc332ghs.1 uc332ghs.1 
ENSMUST00000260282.1 ENSMUSG00000123809 ENSMUST00000260282.1 ENSMUSG00000123809 (from geneSymbol) uc332ghu.1 uc332ghu.1 
ENSMUST00000260299.1 ENSMUSG00000123810 ENSMUST00000260299.1 ENSMUSG00000123810 (from geneSymbol) uc332gil.1 uc332gil.1 
ENSMUST00000260301.1 ENSMUSG00000123811 ENSMUST00000260301.1 ENSMUSG00000123811 (from geneSymbol) uc332gin.1 uc332gin.1 
ENSMUST00000260302.1 ENSMUSG00000123812 ENSMUST00000260302.1 ENSMUSG00000123812 (from geneSymbol) uc332gio.1 uc332gio.1 
ENSMUST00000260307.1 ENSMUSG00000123813 ENSMUST00000260307.1 ENSMUSG00000123813 (from geneSymbol) uc332git.1 uc332git.1 
ENSMUST00000260310.1 Gm36849 ENSMUST00000260310.1 Gm36849 (from geneSymbol) uc332giw.1 uc332giw.1 
ENSMUST00000260313.1 ENSMUSG00000123814 ENSMUST00000260313.1 ENSMUSG00000123814 (from geneSymbol) uc332giz.1 uc332giz.1 
ENSMUST00000260314.1 ENSMUSG00000123815 ENSMUST00000260314.1 ENSMUSG00000123815 (from geneSymbol) uc332gja.1 uc332gja.1 
ENSMUST00000260317.1 ENSMUSG00000123816 ENSMUST00000260317.1 ENSMUSG00000123816 (from geneSymbol) uc332gjd.1 uc332gjd.1 
ENSMUST00000260324.1 ENSMUSG00000123817 ENSMUST00000260324.1 ENSMUSG00000123817 (from geneSymbol) uc332gjk.1 uc332gjk.1 
ENSMUST00000260326.1 ENSMUSG00000123819 ENSMUST00000260326.1 ENSMUSG00000123819 (from geneSymbol) uc332gjl.1 uc332gjl.1 
ENSMUST00000260329.1 Gm10602 ENSMUST00000260329.1 Gm10602 (from geneSymbol) AK138181 uc332gjo.1 uc332gjo.1 
ENSMUST00000260338.1 Gm30513 ENSMUST00000260338.1 Gm30513 (from geneSymbol) uc332gjx.1 uc332gjx.1 
ENSMUST00000260360.1 ENSMUSG00000123820 ENSMUST00000260360.1 ENSMUSG00000123820 (from geneSymbol) uc332gkt.1 uc332gkt.1 
ENSMUST00000260362.1 ENSMUSG00000123821 ENSMUST00000260362.1 ENSMUSG00000123821 (from geneSymbol) uc332gkv.1 uc332gkv.1 
ENSMUST00000260364.1 ENSMUSG00000123822 ENSMUST00000260364.1 ENSMUSG00000123822 (from geneSymbol) uc332gkx.1 uc332gkx.1 
ENSMUST00000260365.1 ENSMUSG00000123823 ENSMUST00000260365.1 ENSMUSG00000123823 (from geneSymbol) uc332gky.1 uc332gky.1 
ENSMUST00000260366.1 ENSMUSG00000123824 ENSMUST00000260366.1 ENSMUSG00000123824 (from geneSymbol) DQ555127 uc332gkz.1 uc332gkz.1 
ENSMUST00000260368.1 ENSMUSG00000123825 ENSMUST00000260368.1 ENSMUSG00000123825 (from geneSymbol) uc332glb.1 uc332glb.1 
ENSMUST00000260385.1 ENSMUSG00000123826 ENSMUST00000260385.1 ENSMUSG00000123826 (from geneSymbol) uc332gls.1 uc332gls.1 
ENSMUST00000260391.1 ENSMUSG00000123827 ENSMUST00000260391.1 ENSMUSG00000123827 (from geneSymbol) uc332gly.1 uc332gly.1 
ENSMUST00000260392.1 ENSMUSG00000123828 ENSMUST00000260392.1 ENSMUSG00000123828 (from geneSymbol) uc332glz.1 uc332glz.1 
ENSMUST00000260398.1 ENSMUSG00000123830 ENSMUST00000260398.1 ENSMUSG00000123830 (from geneSymbol) uc332gme.1 uc332gme.1 
ENSMUST00000260400.1 ENSMUSG00000123831 ENSMUST00000260400.1 ENSMUSG00000123831 (from geneSymbol) uc332gmg.1 uc332gmg.1 
ENSMUST00000260403.1 ENSMUSG00000123832 ENSMUST00000260403.1 ENSMUSG00000123832 (from geneSymbol) uc332gmj.1 uc332gmj.1 
ENSMUST00000260421.1 Gm19466 ENSMUST00000260421.1 Gm19466 (from geneSymbol) AK044363 uc332gnb.1 uc332gnb.1 
ENSMUST00000260430.1 ENSMUSG00000123833 ENSMUST00000260430.1 ENSMUSG00000123833 (from geneSymbol) uc332gnk.1 uc332gnk.1 
ENSMUST00000260431.1 ENSMUSG00000123834 ENSMUST00000260431.1 ENSMUSG00000123834 (from geneSymbol) uc332gnl.1 uc332gnl.1 
ENSMUST00000260433.1 ENSMUSG00000123835 ENSMUST00000260433.1 ENSMUSG00000123835 (from geneSymbol) uc332gnn.1 uc332gnn.1 
ENSMUST00000260434.1 ENSMUSG00000123836 ENSMUST00000260434.1 ENSMUSG00000123836 (from geneSymbol) uc332gno.1 uc332gno.1 
ENSMUST00000260435.1 ENSMUSG00000123837 ENSMUST00000260435.1 ENSMUSG00000123837 (from geneSymbol) uc332gnp.1 uc332gnp.1 
ENSMUST00000260440.1 ENSMUSG00000123838 ENSMUST00000260440.1 ENSMUSG00000123838 (from geneSymbol) uc332gnu.1 uc332gnu.1 
ENSMUST00000260441.1 ENSMUSG00000123839 ENSMUST00000260441.1 ENSMUSG00000123839 (from geneSymbol) uc332gnv.1 uc332gnv.1 
ENSMUST00000260442.1 ENSMUSG00000123840 ENSMUST00000260442.1 ENSMUSG00000123840 (from geneSymbol) uc332gnw.1 uc332gnw.1 
ENSMUST00000260449.1 ENSMUSG00000123841 ENSMUST00000260449.1 ENSMUSG00000123841 (from geneSymbol) uc332god.1 uc332god.1 
ENSMUST00000260452.1 ENSMUSG00000123843 ENSMUST00000260452.1 ENSMUSG00000123843 (from geneSymbol) uc332gof.1 uc332gof.1 
ENSMUST00000260478.1 Gm56496 ENSMUST00000260478.1 Gm56496 (from geneSymbol) uc332gpf.1 uc332gpf.1 
ENSMUST00000260490.1 ENSMUSG00000123844 ENSMUST00000260490.1 ENSMUSG00000123844 (from geneSymbol) uc332gpr.1 uc332gpr.1 
ENSMUST00000260494.1 Gm38324 ENSMUST00000260494.1 Gm38324 (from geneSymbol) uc332gpv.1 uc332gpv.1 
ENSMUST00000260495.1 ENSMUSG00000123845 ENSMUST00000260495.1 ENSMUSG00000123845 (from geneSymbol) uc332gpw.1 uc332gpw.1 
ENSMUST00000260496.1 ENSMUSG00000123846 ENSMUST00000260496.1 ENSMUSG00000123846 (from geneSymbol) uc332gpx.1 uc332gpx.1 
ENSMUST00000260497.1 ENSMUSG00000123847 ENSMUST00000260497.1 ENSMUSG00000123847 (from geneSymbol) uc332gpy.1 uc332gpy.1 
ENSMUST00000260500.1 Gm45305 ENSMUST00000260500.1 Gm45305 (from geneSymbol) uc332gqb.1 uc332gqb.1 
ENSMUST00000260503.1 ENSMUSG00000123848 ENSMUST00000260503.1 ENSMUSG00000123848 (from geneSymbol) uc332gqe.1 uc332gqe.1 
ENSMUST00000260513.1 ENSMUSG00000123849 ENSMUST00000260513.1 ENSMUSG00000123849 (from geneSymbol) uc332gqo.1 uc332gqo.1 
ENSMUST00000260518.1 ENSMUSG00000123850 ENSMUST00000260518.1 ENSMUSG00000123850 (from geneSymbol) uc332gqt.1 uc332gqt.1 
ENSMUST00000260519.1 ENSMUSG00000123851 ENSMUST00000260519.1 ENSMUSG00000123851 (from geneSymbol) uc332gqu.1 uc332gqu.1 
ENSMUST00000260520.1 ENSMUSG00000123852 ENSMUST00000260520.1 ENSMUSG00000123852 (from geneSymbol) uc332gqv.1 uc332gqv.1 
ENSMUST00000260521.1 ENSMUSG00000123853 ENSMUST00000260521.1 ENSMUSG00000123853 (from geneSymbol) uc332gqw.1 uc332gqw.1 
ENSMUST00000260522.1 ENSMUSG00000123854 ENSMUST00000260522.1 ENSMUSG00000123854 (from geneSymbol) uc332gqx.1 uc332gqx.1 
ENSMUST00000260524.1 ENSMUSG00000123855 ENSMUST00000260524.1 ENSMUSG00000123855 (from geneSymbol) uc332gqz.1 uc332gqz.1 
ENSMUST00000260528.1 Gm29065 ENSMUST00000260528.1 Gm29065 (from geneSymbol) uc332grd.1 uc332grd.1 
ENSMUST00000260531.1 ENSMUSG00000123856 ENSMUST00000260531.1 ENSMUSG00000123856 (from geneSymbol) uc332grg.1 uc332grg.1 
ENSMUST00000260532.1 ENSMUSG00000123857 ENSMUST00000260532.1 ENSMUSG00000123857 (from geneSymbol) uc332grh.1 uc332grh.1 
ENSMUST00000260533.1 ENSMUSG00000123858 ENSMUST00000260533.1 ENSMUSG00000123858 (from geneSymbol) uc332gri.1 uc332gri.1 
ENSMUST00000260536.1 ENSMUSG00000123859 ENSMUST00000260536.1 ENSMUSG00000123859 (from geneSymbol) uc332grl.1 uc332grl.1 
ENSMUST00000260544.1 ENSMUSG00000123860 ENSMUST00000260544.1 ENSMUSG00000123860 (from geneSymbol) uc332grt.1 uc332grt.1 
ENSMUST00000260545.1 4632427E13Rik ENSMUST00000260545.1 4632427E13Rik (from geneSymbol) AK084903 uc332gru.1 uc332gru.1 
ENSMUST00000260562.1 ENSMUSG00000123861 ENSMUST00000260562.1 ENSMUSG00000123861 (from geneSymbol) uc332gsl.1 uc332gsl.1 
ENSMUST00000260563.1 Gm33576 ENSMUST00000260563.1 Gm33576 (from geneSymbol) uc332gsm.1 uc332gsm.1 
ENSMUST00000260566.1 ENSMUSG00000123862 ENSMUST00000260566.1 ENSMUSG00000123862 (from geneSymbol) uc332gsp.1 uc332gsp.1 
ENSMUST00000260572.1 ENSMUSG00000123863 ENSMUST00000260572.1 ENSMUSG00000123863 (from geneSymbol) uc332gsu.1 uc332gsu.1 
ENSMUST00000260573.1 ENSMUSG00000123864 ENSMUST00000260573.1 ENSMUSG00000123864 (from geneSymbol) uc332gsv.1 uc332gsv.1 
ENSMUST00000260575.1 ENSMUSG00000123865 ENSMUST00000260575.1 ENSMUSG00000123865 (from geneSymbol) uc332gsx.1 uc332gsx.1 
ENSMUST00000260576.1 ENSMUSG00000123866 ENSMUST00000260576.1 ENSMUSG00000123866 (from geneSymbol) uc332gsy.1 uc332gsy.1 
ENSMUST00000260579.1 ENSMUSG00000123867 ENSMUST00000260579.1 ENSMUSG00000123867 (from geneSymbol) uc332gtb.1 uc332gtb.1 
ENSMUST00000260580.1 Gm30693 ENSMUST00000260580.1 Gm30693 (from geneSymbol) KY467746 uc332gtc.1 uc332gtc.1 
ENSMUST00000260594.1 ENSMUSG00000123868 ENSMUST00000260594.1 ENSMUSG00000123868 (from geneSymbol) uc332gtq.1 uc332gtq.1 
ENSMUST00000260595.1 ENSMUSG00000123869 ENSMUST00000260595.1 ENSMUSG00000123869 (from geneSymbol) uc332gtr.1 uc332gtr.1 
ENSMUST00000260596.1 ENSMUSG00000123870 ENSMUST00000260596.1 ENSMUSG00000123870 (from geneSymbol) uc332gts.1 uc332gts.1 
ENSMUST00000260598.1 ENSMUSG00000123871 ENSMUST00000260598.1 ENSMUSG00000123871 (from geneSymbol) uc332gtu.1 uc332gtu.1 
ENSMUST00000260607.1 ENSMUSG00000123872 ENSMUST00000260607.1 ENSMUSG00000123872 (from geneSymbol) uc332gud.1 uc332gud.1 
ENSMUST00000260611.1 ENSMUSG00000123873 ENSMUST00000260611.1 ENSMUSG00000123873 (from geneSymbol) uc332guh.1 uc332guh.1 
ENSMUST00000260612.1 ENSMUSG00000123874 ENSMUST00000260612.1 ENSMUSG00000123874 (from geneSymbol) uc332gui.1 uc332gui.1 
ENSMUST00000260613.1 ENSMUSG00000123875 ENSMUST00000260613.1 ENSMUSG00000123875 (from geneSymbol) uc332guj.1 uc332guj.1 
ENSMUST00000260614.1 ENSMUSG00000123876 ENSMUST00000260614.1 ENSMUSG00000123876 (from geneSymbol) uc332guk.1 uc332guk.1 
ENSMUST00000260616.1 ENSMUSG00000123878 ENSMUST00000260616.1 ENSMUSG00000123878 (from geneSymbol) uc332gul.1 uc332gul.1 
ENSMUST00000260617.1 ENSMUSG00000123879 ENSMUST00000260617.1 ENSMUSG00000123879 (from geneSymbol) uc332gum.1 uc332gum.1 
ENSMUST00000260619.1 ENSMUSG00000123880 ENSMUST00000260619.1 ENSMUSG00000123880 (from geneSymbol) uc332guo.1 uc332guo.1 
ENSMUST00000260621.1 ENSMUSG00000123881 ENSMUST00000260621.1 ENSMUSG00000123881 (from geneSymbol) uc332guq.1 uc332guq.1 
ENSMUST00000260623.1 ENSMUSG00000123882 ENSMUST00000260623.1 ENSMUSG00000123882 (from geneSymbol) uc332gus.1 uc332gus.1 
ENSMUST00000260624.1 ENSMUSG00000123883 ENSMUST00000260624.1 ENSMUSG00000123883 (from geneSymbol) uc332gut.1 uc332gut.1 
ENSMUST00000260628.1 ENSMUSG00000123885 ENSMUST00000260628.1 ENSMUSG00000123885 (from geneSymbol) uc332guw.1 uc332guw.1 
ENSMUST00000260629.1 F730035P03Rik ENSMUST00000260629.1 F730035P03Rik (from geneSymbol) AK089468 uc332gux.1 uc332gux.1 
ENSMUST00000260630.1 Gm16080 ENSMUST00000260630.1 Gm16080 (from geneSymbol) uc332guy.1 uc332guy.1 
ENSMUST00000260639.1 ENSMUSG00000123886 ENSMUST00000260639.1 ENSMUSG00000123886 (from geneSymbol) uc332gvh.1 uc332gvh.1 
ENSMUST00000260640.1 ENSMUSG00000123887 ENSMUST00000260640.1 ENSMUSG00000123887 (from geneSymbol) uc332gvi.1 uc332gvi.1 
ENSMUST00000260641.1 ENSMUSG00000123888 ENSMUST00000260641.1 ENSMUSG00000123888 (from geneSymbol) uc332gvj.1 uc332gvj.1 
ENSMUST00000260642.1 ENSMUSG00000123889 ENSMUST00000260642.1 ENSMUSG00000123889 (from geneSymbol) uc332gvk.1 uc332gvk.1 
ENSMUST00000260645.1 ENSMUSG00000123891 ENSMUST00000260645.1 ENSMUSG00000123891 (from geneSymbol) uc332gvl.1 uc332gvl.1 
ENSMUST00000260647.1 ENSMUSG00000123892 ENSMUST00000260647.1 ENSMUSG00000123892 (from geneSymbol) uc332gvn.1 uc332gvn.1 
ENSMUST00000260648.1 ENSMUSG00000123893 ENSMUST00000260648.1 ENSMUSG00000123893 (from geneSymbol) uc332gvo.1 uc332gvo.1 
ENSMUST00000260649.1 ENSMUSG00000123894 ENSMUST00000260649.1 ENSMUSG00000123894 (from geneSymbol) uc332gvp.1 uc332gvp.1 
ENSMUST00000260651.1 ENSMUSG00000123895 ENSMUST00000260651.1 ENSMUSG00000123895 (from geneSymbol) uc332gvr.1 uc332gvr.1 
ENSMUST00000260659.1 ENSMUSG00000123896 ENSMUST00000260659.1 ENSMUSG00000123896 (from geneSymbol) uc332gvx.1 uc332gvx.1 
ENSMUST00000260669.1 Gm31314 ENSMUST00000260669.1 Gm31314 (from geneSymbol) BC100494 uc332gwh.1 uc332gwh.1 
ENSMUST00000260688.1 ENSMUSG00000123897 ENSMUST00000260688.1 ENSMUSG00000123897 (from geneSymbol) uc332gxa.1 uc332gxa.1 
ENSMUST00000260689.1 ENSMUSG00000123898 ENSMUST00000260689.1 ENSMUSG00000123898 (from geneSymbol) uc332gxb.1 uc332gxb.1 
ENSMUST00000260693.1 ENSMUSG00000123899 ENSMUST00000260693.1 ENSMUSG00000123899 (from geneSymbol) uc332gxf.1 uc332gxf.1 
ENSMUST00000260697.1 Tlx1os ENSMUST00000260697.1 Tlx1os (from geneSymbol) uc332gxj.1 uc332gxj.1 
ENSMUST00000260701.1 ENSMUSG00000123900 ENSMUST00000260701.1 ENSMUSG00000123900 (from geneSymbol) uc332gxn.1 uc332gxn.1 
ENSMUST00000260703.1 Gm56990 ENSMUST00000260703.1 Gm56990 (from geneSymbol) uc332gxp.1 uc332gxp.1 
ENSMUST00000260704.1 ENSMUSG00000123901 ENSMUST00000260704.1 ENSMUSG00000123901 (from geneSymbol) uc332gxq.1 uc332gxq.1 
ENSMUST00000260705.1 ENSMUSG00000123902 ENSMUST00000260705.1 ENSMUSG00000123902 (from geneSymbol) uc332gxr.1 uc332gxr.1 
ENSMUST00000260714.1 ENSMUSG00000123903 ENSMUST00000260714.1 ENSMUSG00000123903 (from geneSymbol) uc332gya.1 uc332gya.1 
ENSMUST00000260715.1 ENSMUSG00000123904 ENSMUST00000260715.1 ENSMUSG00000123904 (from geneSymbol) uc332gyb.1 uc332gyb.1 
ENSMUST00000260716.1 ENSMUSG00000123905 ENSMUST00000260716.1 ENSMUSG00000123905 (from geneSymbol) uc332gyc.1 uc332gyc.1 
ENSMUST00000260717.1 ENSMUSG00000123906 ENSMUST00000260717.1 ENSMUSG00000123906 (from geneSymbol) uc332gyd.1 uc332gyd.1 
ENSMUST00000260719.1 ENSMUSG00000123907 ENSMUST00000260719.1 ENSMUSG00000123907 (from geneSymbol) uc332gyf.1 uc332gyf.1 
ENSMUST00000260720.1 1700030F04Rik ENSMUST00000260720.1 1700030F04Rik (from geneSymbol) AK006540 uc332gyg.1 uc332gyg.1 
ENSMUST00000260769.1 ENSMUSG00000123908 ENSMUST00000260769.1 ENSMUSG00000123908 (from geneSymbol) uc332hac.1 uc332hac.1 
ENSMUST00000260770.1 ENSMUSG00000123909 ENSMUST00000260770.1 ENSMUSG00000123909 (from geneSymbol) LF197775 uc332had.1 uc332had.1 
ENSMUST00000260771.1 ENSMUSG00000123910 ENSMUST00000260771.1 ENSMUSG00000123910 (from geneSymbol) uc332hae.1 uc332hae.1 
ENSMUST00000260773.1 ENSMUSG00000123911 ENSMUST00000260773.1 ENSMUSG00000123911 (from geneSymbol) uc332hag.1 uc332hag.1 
ENSMUST00000260775.1 ENSMUSG00000123912 ENSMUST00000260775.1 ENSMUSG00000123912 (from geneSymbol) uc332hai.1 uc332hai.1 
ENSMUST00000260778.1 ENSMUSG00000123913 ENSMUST00000260778.1 ENSMUSG00000123913 (from geneSymbol) uc332hal.1 uc332hal.1 
ENSMUST00000260782.1 ENSMUSG00000123914 ENSMUST00000260782.1 ENSMUSG00000123914 (from geneSymbol) uc332hap.1 uc332hap.1 
ENSMUST00000260788.1 ENSMUSG00000123915 ENSMUST00000260788.1 ENSMUSG00000123915 (from geneSymbol) uc332hav.1 uc332hav.1 
ENSMUST00000260789.1 ENSMUSG00000123916 ENSMUST00000260789.1 ENSMUSG00000123916 (from geneSymbol) uc332haw.1 uc332haw.1 
ENSMUST00000260790.1 ENSMUSG00000123917 ENSMUST00000260790.1 ENSMUSG00000123917 (from geneSymbol) uc332hax.1 uc332hax.1 
ENSMUST00000260791.1 ENSMUSG00000123918 ENSMUST00000260791.1 ENSMUSG00000123918 (from geneSymbol) uc332hay.1 uc332hay.1 
ENSMUST00000260792.1 ENSMUSG00000123919 ENSMUST00000260792.1 ENSMUSG00000123919 (from geneSymbol) uc332haz.1 uc332haz.1 
ENSMUST00000260796.1 ENSMUSG00000123920 ENSMUST00000260796.1 ENSMUSG00000123920 (from geneSymbol) uc332hbd.1 uc332hbd.1 
ENSMUST00000260797.1 ENSMUSG00000123921 ENSMUST00000260797.1 ENSMUSG00000123921 (from geneSymbol) uc332hbe.1 uc332hbe.1 
ENSMUST00000260798.1 ENSMUSG00000123922 ENSMUST00000260798.1 ENSMUSG00000123922 (from geneSymbol) uc332hbf.1 uc332hbf.1 
ENSMUST00000260800.1 ENSMUSG00000123923 ENSMUST00000260800.1 ENSMUSG00000123923 (from geneSymbol) uc332hbh.1 uc332hbh.1 
ENSMUST00000260807.1 ENSMUSG00000123924 ENSMUST00000260807.1 ENSMUSG00000123924 (from geneSymbol) uc332hbo.1 uc332hbo.1 
ENSMUST00000260810.1 Gm36860 ENSMUST00000260810.1 Gm36860 (from geneSymbol) uc332hbr.1 uc332hbr.1 
ENSMUST00000260814.1 Gm50199 ENSMUST00000260814.1 Gm50199 (from geneSymbol) uc332hbv.1 uc332hbv.1 
ENSMUST00000260815.1 ENSMUSG00000123925 ENSMUST00000260815.1 ENSMUSG00000123925 (from geneSymbol) uc332hbw.1 uc332hbw.1 
ENSMUST00000260818.1 ENSMUSG00000123926 ENSMUST00000260818.1 ENSMUSG00000123926 (from geneSymbol) uc332hbz.1 uc332hbz.1 
ENSMUST00000260821.1 ENSMUSG00000123927 ENSMUST00000260821.1 ENSMUSG00000123927 (from geneSymbol) uc332hcc.1 uc332hcc.1 
ENSMUST00000260828.1 Gm5600 ENSMUST00000260828.1 Gm5600 (from geneSymbol) AK035124 uc332hcj.1 uc332hcj.1 
ENSMUST00000260829.1 ENSMUSG00000123928 ENSMUST00000260829.1 ENSMUSG00000123928 (from geneSymbol) uc332hck.1 uc332hck.1 
ENSMUST00000260830.1 ENSMUSG00000123929 ENSMUST00000260830.1 ENSMUSG00000123929 (from geneSymbol) uc332hcl.1 uc332hcl.1 
ENSMUST00000260837.1 ENSMUSG00000123930 ENSMUST00000260837.1 ENSMUSG00000123930 (from geneSymbol) uc332hcs.1 uc332hcs.1 
ENSMUST00000260841.1 ENSMUSG00000123931 ENSMUST00000260841.1 ENSMUSG00000123931 (from geneSymbol) uc332hcw.1 uc332hcw.1 
ENSMUST00000260846.1 ENSMUSG00000123932 ENSMUST00000260846.1 ENSMUSG00000123932 (from geneSymbol) uc332hdb.1 uc332hdb.1 
ENSMUST00000260866.1 ENSMUSG00000123933 ENSMUST00000260866.1 ENSMUSG00000123933 (from geneSymbol) uc332hdv.1 uc332hdv.1 
ENSMUST00000260867.1 ENSMUSG00000123934 ENSMUST00000260867.1 ENSMUSG00000123934 (from geneSymbol) uc332hdw.1 uc332hdw.1 
ENSMUST00000260868.1 2810001A02Rik ENSMUST00000260868.1 2810001A02Rik (from geneSymbol) uc332hdx.1 uc332hdx.1 
ENSMUST00000260870.1 ENSMUSG00000123935 ENSMUST00000260870.1 ENSMUSG00000123935 (from geneSymbol) uc332hdz.1 uc332hdz.1 
ENSMUST00000260871.1 ENSMUSG00000123936 ENSMUST00000260871.1 ENSMUSG00000123936 (from geneSymbol) uc332hea.1 uc332hea.1 
ENSMUST00000260873.1 Gm35166 ENSMUST00000260873.1 Gm35166 (from geneSymbol) uc332hec.1 uc332hec.1 
ENSMUST00000260874.1 ENSMUSG00000123937 ENSMUST00000260874.1 ENSMUSG00000123937 (from geneSymbol) uc332hed.1 uc332hed.1 
ENSMUST00000260875.1 ENSMUSG00000123938 ENSMUST00000260875.1 ENSMUSG00000123938 (from geneSymbol) uc332hee.1 uc332hee.1 
ENSMUST00000260877.1 ENSMUSG00000123939 ENSMUST00000260877.1 ENSMUSG00000123939 (from geneSymbol) uc332heg.1 uc332heg.1 
ENSMUST00000260880.1 ENSMUSG00000123940 ENSMUST00000260880.1 ENSMUSG00000123940 (from geneSymbol) uc332hej.1 uc332hej.1 
ENSMUST00000260885.1 ENSMUSG00000123941 ENSMUST00000260885.1 ENSMUSG00000123941 (from geneSymbol) uc332heo.1 uc332heo.1 
ENSMUST00000260886.1 BC024386 ENSMUST00000260886.1 BC024386 (from geneSymbol) BC087948 uc332hep.1 uc332hep.1 
ENSMUST00000260990.1 ENSMUSG00000123942 ENSMUST00000260990.1 ENSMUSG00000123942 (from geneSymbol) uc332hin.1 uc332hin.1 
ENSMUST00000260991.1 ENSMUSG00000123943 ENSMUST00000260991.1 ENSMUSG00000123943 (from geneSymbol) uc332hio.1 uc332hio.1 
ENSMUST00000260992.1 ENSMUSG00000123944 ENSMUST00000260992.1 ENSMUSG00000123944 (from geneSymbol) uc332hip.1 uc332hip.1 
ENSMUST00000260993.1 ENSMUSG00000123945 ENSMUST00000260993.1 ENSMUSG00000123945 (from geneSymbol) uc332hiq.1 uc332hiq.1 
ENSMUST00000261003.1 ENSMUSG00000123946 ENSMUST00000261003.1 ENSMUSG00000123946 (from geneSymbol) uc332hja.1 uc332hja.1 
ENSMUST00000261004.1 ENSMUSG00000123947 ENSMUST00000261004.1 ENSMUSG00000123947 (from geneSymbol) uc332hjb.1 uc332hjb.1 
ENSMUST00000261007.1 ENSMUSG00000123948 ENSMUST00000261007.1 ENSMUSG00000123948 (from geneSymbol) uc332hje.1 uc332hje.1 
ENSMUST00000261023.1 ENSMUSG00000123949 ENSMUST00000261023.1 ENSMUSG00000123949 (from geneSymbol) uc332hju.1 uc332hju.1 
ENSMUST00000261024.1 ENSMUSG00000123950 ENSMUST00000261024.1 ENSMUSG00000123950 (from geneSymbol) uc332hjv.1 uc332hjv.1 
ENSMUST00000261028.1 Gm56774 ENSMUST00000261028.1 predicted gene, 41999 (from RefSeq NR_168331.1) NR_168331 uc332hjz.1 uc332hjz.1 
ENSMUST00000261050.1 ENSMUSG00000123951 ENSMUST00000261050.1 ENSMUSG00000123951 (from geneSymbol) uc332hkv.1 uc332hkv.1 
ENSMUST00000261053.1 ENSMUSG00000123952 ENSMUST00000261053.1 ENSMUSG00000123952 (from geneSymbol) uc332hky.1 uc332hky.1 
ENSMUST00000261054.1 ENSMUSG00000123953 ENSMUST00000261054.1 ENSMUSG00000123953 (from geneSymbol) uc332hkz.1 uc332hkz.1 
ENSMUST00000261056.1 Gm11264 ENSMUST00000261056.1 Gm11264 (from geneSymbol) AK036601 uc332hlb.1 uc332hlb.1 
ENSMUST00000261075.1 4930449E01Rik ENSMUST00000261075.1 4930449E01Rik (from geneSymbol) AK015429 uc332hlu.1 uc332hlu.1 
ENSMUST00000261113.1 ENSMUSG00000123954 ENSMUST00000261113.1 ENSMUSG00000123954 (from geneSymbol) uc332hng.1 uc332hng.1 
ENSMUST00000261114.1 ENSMUSG00000123955 ENSMUST00000261114.1 ENSMUSG00000123955 (from geneSymbol) uc332hnh.1 uc332hnh.1 
ENSMUST00000261118.1 ENSMUSG00000123956 ENSMUST00000261118.1 ENSMUSG00000123956 (from geneSymbol) uc332hnl.1 uc332hnl.1 
ENSMUST00000261123.1 ENSMUSG00000123957 ENSMUST00000261123.1 ENSMUSG00000123957 (from geneSymbol) uc332hnq.1 uc332hnq.1 
ENSMUST00000261125.1 ENSMUSG00000123958 ENSMUST00000261125.1 ENSMUSG00000123958 (from geneSymbol) uc332hns.1 uc332hns.1 
ENSMUST00000261126.1 ENSMUSG00000123959 ENSMUST00000261126.1 ENSMUSG00000123959 (from geneSymbol) uc332hnt.1 uc332hnt.1 
ENSMUST00000261128.1 ENSMUSG00000123960 ENSMUST00000261128.1 ENSMUSG00000123960 (from geneSymbol) uc332hnv.1 uc332hnv.1 
ENSMUST00000261136.1 ENSMUSG00000123961 ENSMUST00000261136.1 ENSMUSG00000123961 (from geneSymbol) uc332hod.1 uc332hod.1 
ENSMUST00000261139.1 Gm36862 ENSMUST00000261139.1 Gm36862 (from geneSymbol) uc332hog.1 uc332hog.1 
ENSMUST00000261163.1 ENSMUSG00000123962 ENSMUST00000261163.1 ENSMUSG00000123962 (from geneSymbol) uc332hpe.1 uc332hpe.1 
ENSMUST00000261165.1 Gm57209 ENSMUST00000261165.1 Gm57209 (from geneSymbol) uc332hpg.1 uc332hpg.1 
ENSMUST00000261180.1 ENSMUSG00000123963 ENSMUST00000261180.1 ENSMUSG00000123963 (from geneSymbol) uc332hpv.1 uc332hpv.1 
ENSMUST00000261183.1 ENSMUSG00000123964 ENSMUST00000261183.1 ENSMUSG00000123964 (from geneSymbol) uc332hpy.1 uc332hpy.1 
ENSMUST00000261190.1 ENSMUSG00000123965 ENSMUST00000261190.1 ENSMUSG00000123965 (from geneSymbol) uc332hqf.1 uc332hqf.1 
ENSMUST00000261193.1 ENSMUSG00000123966 ENSMUST00000261193.1 ENSMUSG00000123966 (from geneSymbol) uc332hqi.1 uc332hqi.1 
ENSMUST00000261196.1 ENSMUSG00000123968 ENSMUST00000261196.1 ENSMUSG00000123968 (from geneSymbol) AK006502 uc332hqk.1 uc332hqk.1 
ENSMUST00000261197.1 ENSMUSG00000123969 ENSMUST00000261197.1 ENSMUSG00000123969 (from geneSymbol) uc332hql.1 uc332hql.1 
ENSMUST00000261198.1 Gm13523 ENSMUST00000261198.1 Gm13523 (from geneSymbol) KY467847 uc332hqm.1 uc332hqm.1 
ENSMUST00000261201.1 ENSMUSG00000123970 ENSMUST00000261201.1 ENSMUSG00000123970 (from geneSymbol) uc332hqp.1 uc332hqp.1 
ENSMUST00000261202.1 ENSMUSG00000123971 ENSMUST00000261202.1 ENSMUSG00000123971 (from geneSymbol) uc332hqq.1 uc332hqq.1 
ENSMUST00000261204.1 ENSMUSG00000123973 ENSMUST00000261204.1 ENSMUSG00000123973 (from geneSymbol) uc332hqr.1 uc332hqr.1 
ENSMUST00000261205.1 ENSMUSG00000123974 ENSMUST00000261205.1 ENSMUSG00000123974 (from geneSymbol) uc332hqs.1 uc332hqs.1 
ENSMUST00000261206.1 ENSMUSG00000123975 ENSMUST00000261206.1 ENSMUSG00000123975 (from geneSymbol) uc332hqt.1 uc332hqt.1 
ENSMUST00000261208.1 ENSMUSG00000123976 ENSMUST00000261208.1 ENSMUSG00000123976 (from geneSymbol) uc332hqv.1 uc332hqv.1 
ENSMUST00000261211.1 ENSMUSG00000123977 ENSMUST00000261211.1 ENSMUSG00000123977 (from geneSymbol) uc332hqy.1 uc332hqy.1 
ENSMUST00000261213.1 4933433G19Rik ENSMUST00000261213.1 4933433G19Rik (from geneSymbol) AK017041 uc332hra.1 uc332hra.1 
ENSMUST00000261220.1 Gm17135 ENSMUST00000261220.1 Gm17135 (from geneSymbol) uc332hrg.1 uc332hrg.1 
ENSMUST00000261223.1 ENSMUSG00000123980 ENSMUST00000261223.1 ENSMUSG00000123980 (from geneSymbol) uc332hri.1 uc332hri.1 
ENSMUST00000261225.1 ENSMUSG00000123981 ENSMUST00000261225.1 ENSMUSG00000123981 (from geneSymbol) uc332hrk.1 uc332hrk.1 
ENSMUST00000261232.1 Gm43077 ENSMUST00000261232.1 Gm43077 (from geneSymbol) uc332hrr.1 uc332hrr.1 
ENSMUST00000261275.1 ENSMUSG00000123982 ENSMUST00000261275.1 ENSMUSG00000123982 (from geneSymbol) uc332hti.1 uc332hti.1 
ENSMUST00000261278.1 ENSMUSG00000123983 ENSMUST00000261278.1 ENSMUSG00000123983 (from geneSymbol) uc332htl.1 uc332htl.1 
ENSMUST00000261280.1 ENSMUSG00000123984 ENSMUST00000261280.1 ENSMUSG00000123984 (from geneSymbol) uc332htn.1 uc332htn.1 
ENSMUST00000261281.1 ENSMUSG00000123985 ENSMUST00000261281.1 ENSMUSG00000123985 (from geneSymbol) uc332hto.1 uc332hto.1 
ENSMUST00000261284.1 ENSMUSG00000123986 ENSMUST00000261284.1 ENSMUSG00000123986 (from geneSymbol) uc332htr.1 uc332htr.1 
ENSMUST00000261287.1 ENSMUSG00000123987 ENSMUST00000261287.1 ENSMUSG00000123987 (from geneSymbol) uc332htu.1 uc332htu.1 
ENSMUST00000261288.1 Gm57362 ENSMUST00000261288.1 Gm57362 (from geneSymbol) uc332htv.1 uc332htv.1 
ENSMUST00000261293.1 ENSMUSG00000123988 ENSMUST00000261293.1 ENSMUSG00000123988 (from geneSymbol) uc332hua.1 uc332hua.1 
ENSMUST00000261294.1 ENSMUSG00000123989 ENSMUST00000261294.1 ENSMUSG00000123989 (from geneSymbol) uc332hub.1 uc332hub.1 
ENSMUST00000261295.1 ENSMUSG00000123990 ENSMUST00000261295.1 ENSMUSG00000123990 (from geneSymbol) uc332huc.1 uc332huc.1 
ENSMUST00000261296.1 Gm5860 ENSMUST00000261296.1 Gm5860 (from geneSymbol) AK084825 uc332hud.1 uc332hud.1 
ENSMUST00000261314.1 ENSMUSG00000123991 ENSMUST00000261314.1 ENSMUSG00000123991 (from geneSymbol) uc332huv.1 uc332huv.1 
ENSMUST00000261317.1 ENSMUSG00000123992 ENSMUST00000261317.1 ENSMUSG00000123992 (from geneSymbol) uc332huy.1 uc332huy.1 
ENSMUST00000261321.1 Gm7991 ENSMUST00000261321.1 Gm7991 (from geneSymbol) AK006017 uc332hvc.1 uc332hvc.1 
ENSMUST00000261329.1 ENSMUSG00000123994 ENSMUST00000261329.1 ENSMUSG00000123994 (from geneSymbol) uc332hvk.1 uc332hvk.1 
ENSMUST00000261330.1 ENSMUSG00000123995 ENSMUST00000261330.1 ENSMUSG00000123995 (from geneSymbol) uc332hvl.1 uc332hvl.1 
ENSMUST00000261331.1 ENSMUSG00000123996 ENSMUST00000261331.1 ENSMUSG00000123996 (from geneSymbol) uc332hvm.1 uc332hvm.1 
ENSMUST00000261338.1 Gm48313 ENSMUST00000261338.1 Gm48313 (from geneSymbol) uc332hvt.1 uc332hvt.1 
ENSMUST00000261340.1 Gm57203 ENSMUST00000261340.1 Gm57203 (from geneSymbol) uc332hvv.1 uc332hvv.1 
ENSMUST00000261341.1 4930548K13Rik ENSMUST00000261341.1 4930548K13Rik (from geneSymbol) AK016071 uc332hvw.1 uc332hvw.1 
ENSMUST00000261344.1 ENSMUSG00000123998 ENSMUST00000261344.1 ENSMUSG00000123998 (from geneSymbol) uc332hvx.1 uc332hvx.1 
ENSMUST00000261347.1 Gm34646 ENSMUST00000261347.1 Gm34646 (from geneSymbol) uc332hwa.1 uc332hwa.1 
ENSMUST00000261352.1 Gm56737 ENSMUST00000261352.1 Gm56737 (from geneSymbol) uc332hwf.1 uc332hwf.1 
ENSMUST00000261367.1 ENSMUSG00000124001 ENSMUST00000261367.1 ENSMUSG00000124001 (from geneSymbol) uc332hwu.1 uc332hwu.1 
ENSMUST00000261370.1 Gm39038 ENSMUST00000261370.1 Gm39038 (from geneSymbol) uc332hwx.1 uc332hwx.1 
ENSMUST00000261376.1 ENSMUSG00000124002 ENSMUST00000261376.1 ENSMUSG00000124002 (from geneSymbol) uc332hxc.1 uc332hxc.1 
ENSMUST00000261389.1 Hectd2os ENSMUST00000261389.1 Hectd2os (from geneSymbol) AK142254 uc332hxo.1 uc332hxo.1 
ENSMUST00000261561.1 ENSMUSG00000124003 ENSMUST00000261561.1 ENSMUSG00000124003 (from geneSymbol) uc332ied.1 uc332ied.1 
ENSMUST00000261574.1 Gm47133 ENSMUST00000261574.1 Gm47133 (from geneSymbol) uc332ieq.1 uc332ieq.1 
ENSMUST00000261576.1 ENSMUSG00000124004 ENSMUST00000261576.1 ENSMUSG00000124004 (from geneSymbol) uc332ies.1 uc332ies.1 
ENSMUST00000261580.1 ENSMUSG00000124005 ENSMUST00000261580.1 ENSMUSG00000124005 (from geneSymbol) uc332iew.1 uc332iew.1 
ENSMUST00000261581.1 ENSMUSG00000124006 ENSMUST00000261581.1 ENSMUSG00000124006 (from geneSymbol) uc332iex.1 uc332iex.1 
ENSMUST00000261605.1 ENSMUSG00000124007 ENSMUST00000261605.1 ENSMUSG00000124007 (from geneSymbol) uc332ifv.1 uc332ifv.1 
ENSMUST00000261617.1 ENSMUSG00000124008 ENSMUST00000261617.1 ENSMUSG00000124008 (from geneSymbol) uc332igh.1 uc332igh.1 
ENSMUST00000261622.1 1700030C12Rik ENSMUST00000261622.1 1700030C12Rik (from geneSymbol) AK006530 uc332igm.1 uc332igm.1 
ENSMUST00000261627.1 ENSMUSG00000124009 ENSMUST00000261627.1 ENSMUSG00000124009 (from geneSymbol) uc332igr.1 uc332igr.1 
ENSMUST00000261629.1 ENSMUSG00000124010 ENSMUST00000261629.1 ENSMUSG00000124010 (from geneSymbol) uc332igt.1 uc332igt.1 
ENSMUST00000261632.1 ENSMUSG00000124011 ENSMUST00000261632.1 ENSMUSG00000124011 (from geneSymbol) uc332igw.1 uc332igw.1 
ENSMUST00000261633.1 ENSMUSG00000124012 ENSMUST00000261633.1 ENSMUSG00000124012 (from geneSymbol) uc332igx.1 uc332igx.1 
ENSMUST00000261634.1 ENSMUSG00000124013 ENSMUST00000261634.1 ENSMUSG00000124013 (from geneSymbol) uc332igy.1 uc332igy.1 
ENSMUST00000261635.1 ENSMUSG00000124014 ENSMUST00000261635.1 ENSMUSG00000124014 (from geneSymbol) uc332igz.1 uc332igz.1 
ENSMUST00000261638.1 ENSMUSG00000124015 ENSMUST00000261638.1 ENSMUSG00000124015 (from geneSymbol) uc332ihc.1 uc332ihc.1 
ENSMUST00000261649.1 ENSMUSG00000124016 ENSMUST00000261649.1 ENSMUSG00000124016 (from geneSymbol) uc332ihn.1 uc332ihn.1 
ENSMUST00000261650.1 ENSMUSG00000124017 ENSMUST00000261650.1 ENSMUSG00000124017 (from geneSymbol) uc332iho.1 uc332iho.1 
ENSMUST00000261651.1 ENSMUSG00000124018 ENSMUST00000261651.1 ENSMUSG00000124018 (from geneSymbol) uc332ihp.1 uc332ihp.1 
ENSMUST00000261653.1 ENSMUSG00000124019 ENSMUST00000261653.1 ENSMUSG00000124019 (from geneSymbol) uc332ihr.1 uc332ihr.1 
ENSMUST00000261668.1 ENSMUSG00000124020 ENSMUST00000261668.1 ENSMUSG00000124020 (from geneSymbol) uc332iig.1 uc332iig.1 
ENSMUST00000261671.1 Gm16548 ENSMUST00000261671.1 Gm16548 (from geneSymbol) AK149537 uc332iij.1 uc332iij.1 
ENSMUST00000261674.1 ENSMUSG00000124021 ENSMUST00000261674.1 ENSMUSG00000124021 (from geneSymbol) uc332iim.1 uc332iim.1 
ENSMUST00000261675.1 ENSMUSG00000124022 ENSMUST00000261675.1 ENSMUSG00000124022 (from geneSymbol) AK133333 uc332iin.1 uc332iin.1 
ENSMUST00000261682.1 ENSMUSG00000124023 ENSMUST00000261682.1 ENSMUSG00000124023 (from geneSymbol) uc332iiu.1 uc332iiu.1 
ENSMUST00000261683.1 ENSMUSG00000124024 ENSMUST00000261683.1 ENSMUSG00000124024 (from geneSymbol) uc332iiv.1 uc332iiv.1 
ENSMUST00000261684.1 ENSMUSG00000124025 ENSMUST00000261684.1 ENSMUSG00000124025 (from geneSymbol) uc332iiw.1 uc332iiw.1 
ENSMUST00000261685.1 ENSMUSG00000124026 ENSMUST00000261685.1 ENSMUSG00000124026 (from geneSymbol) uc332iix.1 uc332iix.1 
ENSMUST00000261686.1 ENSMUSG00000124027 ENSMUST00000261686.1 ENSMUSG00000124027 (from geneSymbol) uc332iiy.1 uc332iiy.1 
ENSMUST00000261687.1 ENSMUSG00000124028 ENSMUST00000261687.1 ENSMUSG00000124028 (from geneSymbol) uc332iiz.1 uc332iiz.1 
ENSMUST00000261693.1 ENSMUSG00000124029 ENSMUST00000261693.1 ENSMUSG00000124029 (from geneSymbol) uc332ijf.1 uc332ijf.1 
ENSMUST00000261694.1 ENSMUSG00000124030 ENSMUST00000261694.1 ENSMUSG00000124030 (from geneSymbol) uc332ijg.1 uc332ijg.1 
ENSMUST00000261699.1 E330013P04Rik ENSMUST00000261699.1 E330013P04Rik (from geneSymbol) BC076607 uc332ijl.1 uc332ijl.1 
ENSMUST00000261712.1 ENSMUSG00000124031 ENSMUST00000261712.1 ENSMUSG00000124031 (from geneSymbol) uc332ijy.1 uc332ijy.1 
ENSMUST00000261713.1 ENSMUSG00000124032 ENSMUST00000261713.1 ENSMUSG00000124032 (from geneSymbol) uc332ijz.1 uc332ijz.1 
ENSMUST00000261714.1 ENSMUSG00000124033 ENSMUST00000261714.1 ENSMUSG00000124033 (from geneSymbol) uc332ika.1 uc332ika.1 
ENSMUST00000261717.1 ENSMUSG00000124034 ENSMUST00000261717.1 ENSMUSG00000124034 (from geneSymbol) uc332ikd.1 uc332ikd.1 
ENSMUST00000261732.1 ENSMUSG00000124035 ENSMUST00000261732.1 ENSMUSG00000124035 (from geneSymbol) uc332iks.1 uc332iks.1 
ENSMUST00000261735.1 ENSMUSG00000124036 ENSMUST00000261735.1 ENSMUSG00000124036 (from geneSymbol) uc332ikv.1 uc332ikv.1 
ENSMUST00000261736.1 ENSMUSG00000124037 ENSMUST00000261736.1 ENSMUSG00000124037 (from geneSymbol) uc332ikw.1 uc332ikw.1 
ENSMUST00000261740.1 ENSMUSG00000124038 ENSMUST00000261740.1 ENSMUSG00000124038 (from geneSymbol) uc332ila.1 uc332ila.1 
ENSMUST00000261748.1 ENSMUSG00000124039 ENSMUST00000261748.1 ENSMUSG00000124039 (from geneSymbol) uc332ili.1 uc332ili.1 
ENSMUST00000261749.1 ENSMUSG00000124040 ENSMUST00000261749.1 ENSMUSG00000124040 (from geneSymbol) uc332ilj.1 uc332ilj.1 
ENSMUST00000261752.1 ENSMUSG00000124041 ENSMUST00000261752.1 ENSMUSG00000124041 (from geneSymbol) uc332ilm.1 uc332ilm.1 
ENSMUST00000261755.1 ENSMUSG00000124042 ENSMUST00000261755.1 ENSMUSG00000124042 (from geneSymbol) uc332ilp.1 uc332ilp.1 
ENSMUST00000261767.1 ENSMUSG00000124043 ENSMUST00000261767.1 ENSMUSG00000124043 (from geneSymbol) uc332imb.1 uc332imb.1 
ENSMUST00000261769.1 ENSMUSG00000124044 ENSMUST00000261769.1 ENSMUSG00000124044 (from geneSymbol) uc332imd.1 uc332imd.1 
ENSMUST00000261770.1 ENSMUSG00000124045 ENSMUST00000261770.1 ENSMUSG00000124045 (from geneSymbol) uc332ime.1 uc332ime.1 
ENSMUST00000261772.1 ENSMUSG00000124046 ENSMUST00000261772.1 ENSMUSG00000124046 (from geneSymbol) uc332img.1 uc332img.1 
ENSMUST00000261779.1 Gm57255 ENSMUST00000261779.1 Gm57255 (from geneSymbol) AK009869 uc332imn.1 uc332imn.1 
ENSMUST00000261803.1 ENSMUSG00000124047 ENSMUST00000261803.1 ENSMUSG00000124047 (from geneSymbol) uc332inl.1 uc332inl.1 
ENSMUST00000261805.1 ENSMUSG00000124048 ENSMUST00000261805.1 ENSMUSG00000124048 (from geneSymbol) uc332inn.1 uc332inn.1 
ENSMUST00000261807.1 ENSMUSG00000124049 ENSMUST00000261807.1 ENSMUSG00000124049 (from geneSymbol) uc332inp.1 uc332inp.1 
ENSMUST00000261808.1 ENSMUSG00000124050 ENSMUST00000261808.1 ENSMUSG00000124050 (from geneSymbol) uc332inq.1 uc332inq.1 
ENSMUST00000261809.1 ENSMUSG00000124051 ENSMUST00000261809.1 ENSMUSG00000124051 (from geneSymbol) uc332inr.1 uc332inr.1 
ENSMUST00000261815.1 Gm44210 ENSMUST00000261815.1 Gm44210 (from geneSymbol) uc332inx.1 uc332inx.1 
ENSMUST00000261827.1 ENSMUSG00000124052 ENSMUST00000261827.1 ENSMUSG00000124052 (from geneSymbol) uc332ioj.1 uc332ioj.1 
ENSMUST00000261830.1 ENSMUSG00000124053 ENSMUST00000261830.1 ENSMUSG00000124053 (from geneSymbol) uc332iom.1 uc332iom.1 
ENSMUST00000261832.1 ENSMUSG00000124054 ENSMUST00000261832.1 ENSMUSG00000124054 (from geneSymbol) uc332ioo.1 uc332ioo.1 
ENSMUST00000261833.1 ENSMUSG00000124055 ENSMUST00000261833.1 ENSMUSG00000124055 (from geneSymbol) uc332iop.1 uc332iop.1 
ENSMUST00000261835.1 ENSMUSG00000124056 ENSMUST00000261835.1 ENSMUSG00000124056 (from geneSymbol) uc332ior.1 uc332ior.1 
ENSMUST00000261841.1 ENSMUSG00000124057 ENSMUST00000261841.1 ENSMUSG00000124057 (from geneSymbol) uc332iox.1 uc332iox.1 
ENSMUST00000261842.1 ENSMUSG00000124058 ENSMUST00000261842.1 ENSMUSG00000124058 (from geneSymbol) uc332ioy.1 uc332ioy.1 
ENSMUST00000261858.1 ENSMUSG00000124059 ENSMUST00000261858.1 ENSMUSG00000124059 (from geneSymbol) uc332ipo.1 uc332ipo.1 
ENSMUST00000261861.1 Gm40918 ENSMUST00000261861.1 Gm40918 (from geneSymbol) BC048601 uc332ipr.1 uc332ipr.1 
ENSMUST00000261931.1 ENSMUSG00000124060 ENSMUST00000261931.1 ENSMUSG00000124060 (from geneSymbol) uc332isj.1 uc332isj.1 
ENSMUST00000261940.1 Gm28181 ENSMUST00000261940.1 Gm28181 (from geneSymbol) uc332iss.1 uc332iss.1 
ENSMUST00000261942.1 ENSMUSG00000124061 ENSMUST00000261942.1 ENSMUSG00000124061 (from geneSymbol) uc332isu.1 uc332isu.1 
ENSMUST00000261945.1 ENSMUSG00000124062 ENSMUST00000261945.1 ENSMUSG00000124062 (from geneSymbol) uc332isx.1 uc332isx.1 
ENSMUST00000261948.1 4930441J16Rik ENSMUST00000261948.1 4930441J16Rik (from geneSymbol) AK015352 uc332ita.1 uc332ita.1 
ENSMUST00000261960.1 ENSMUSG00000124063 ENSMUST00000261960.1 ENSMUSG00000124063 (from geneSymbol) uc332itm.1 uc332itm.1 
ENSMUST00000261961.1 ENSMUSG00000124064 ENSMUST00000261961.1 ENSMUSG00000124064 (from geneSymbol) LF196680 uc332itn.1 uc332itn.1 
ENSMUST00000261962.1 ENSMUSG00000124065 ENSMUST00000261962.1 ENSMUSG00000124065 (from geneSymbol) AK046057 uc332ito.1 uc332ito.1 
ENSMUST00000261963.1 ENSMUSG00000124066 ENSMUST00000261963.1 ENSMUSG00000124066 (from geneSymbol) uc332itp.1 uc332itp.1 
ENSMUST00000261964.1 Gm45949 ENSMUST00000261964.1 Gm45949 (from geneSymbol) uc332itq.1 uc332itq.1 
ENSMUST00000261982.1 ENSMUSG00000124067 ENSMUST00000261982.1 ENSMUSG00000124067 (from geneSymbol) uc332iui.1 uc332iui.1 
ENSMUST00000261985.1 ENSMUSG00000124068 ENSMUST00000261985.1 ENSMUSG00000124068 (from geneSymbol) uc332iul.1 uc332iul.1 
ENSMUST00000261986.1 ENSMUSG00000124069 ENSMUST00000261986.1 ENSMUSG00000124069 (from geneSymbol) uc332ium.1 uc332ium.1 
ENSMUST00000261988.1 ENSMUSG00000124070 ENSMUST00000261988.1 ENSMUSG00000124070 (from geneSymbol) uc332iuo.1 uc332iuo.1 
ENSMUST00000261992.1 ENSMUSG00000124071 ENSMUST00000261992.1 ENSMUSG00000124071 (from geneSymbol) uc332ius.1 uc332ius.1 
ENSMUST00000261995.1 ENSMUSG00000124072 ENSMUST00000261995.1 ENSMUSG00000124072 (from geneSymbol) uc332iuv.1 uc332iuv.1 
ENSMUST00000261996.1 ENSMUSG00000124073 ENSMUST00000261996.1 ENSMUSG00000124073 (from geneSymbol) uc332iuw.1 uc332iuw.1 
ENSMUST00000261997.1 ENSMUSG00000124074 ENSMUST00000261997.1 ENSMUSG00000124074 (from geneSymbol) uc332iux.1 uc332iux.1 
ENSMUST00000261998.1 ENSMUSG00000124075 ENSMUST00000261998.1 ENSMUSG00000124075 (from geneSymbol) uc332iuy.1 uc332iuy.1 
ENSMUST00000262006.1 ENSMUSG00000124076 ENSMUST00000262006.1 ENSMUSG00000124076 (from geneSymbol) uc332ivg.1 uc332ivg.1 
ENSMUST00000262013.1 ENSMUSG00000124077 ENSMUST00000262013.1 ENSMUSG00000124077 (from geneSymbol) uc332ivn.1 uc332ivn.1 
ENSMUST00000262015.1 ENSMUSG00000124078 ENSMUST00000262015.1 ENSMUSG00000124078 (from geneSymbol) uc332ivp.1 uc332ivp.1 
ENSMUST00000262017.1 ENSMUSG00000124079 ENSMUST00000262017.1 ENSMUSG00000124079 (from geneSymbol) uc332ivr.1 uc332ivr.1 
ENSMUST00000262023.1 ENSMUSG00000124080 ENSMUST00000262023.1 ENSMUSG00000124080 (from geneSymbol) uc332ivx.1 uc332ivx.1 
ENSMUST00000262024.1 ENSMUSG00000124081 ENSMUST00000262024.1 ENSMUSG00000124081 (from geneSymbol) uc332ivy.1 uc332ivy.1 
ENSMUST00000262025.1 ENSMUSG00000124082 ENSMUST00000262025.1 ENSMUSG00000124082 (from geneSymbol) uc332ivz.1 uc332ivz.1 
ENSMUST00000262027.1 ENSMUSG00000124083 ENSMUST00000262027.1 ENSMUSG00000124083 (from geneSymbol) AK007116 uc332iwb.1 uc332iwb.1 
ENSMUST00000262034.1 ENSMUSG00000124084 ENSMUST00000262034.1 ENSMUSG00000124084 (from geneSymbol) uc332iwi.1 uc332iwi.1 
ENSMUST00000262035.1 ENSMUSG00000124085 ENSMUST00000262035.1 ENSMUSG00000124085 (from geneSymbol) uc332iwj.1 uc332iwj.1 
ENSMUST00000262037.1 ENSMUSG00000124086 ENSMUST00000262037.1 ENSMUSG00000124086 (from geneSymbol) uc332iwl.1 uc332iwl.1 
ENSMUST00000262042.1 ENSMUSG00000124087 ENSMUST00000262042.1 ENSMUSG00000124087 (from geneSymbol) uc332iwq.1 uc332iwq.1 
ENSMUST00000262045.1 Gm45646 ENSMUST00000262045.1 Gm45646 (from geneSymbol) uc332iws.1 uc332iws.1 
ENSMUST00000262046.1 ENSMUSG00000124089 ENSMUST00000262046.1 ENSMUSG00000124089 (from geneSymbol) uc332iwt.1 uc332iwt.1 
ENSMUST00000262047.1 Gm15831 ENSMUST00000262047.1 Gm15831 (from geneSymbol) uc332iwu.1 uc332iwu.1 
ENSMUST00000262048.1 ENSMUSG00000124090 ENSMUST00000262048.1 ENSMUSG00000124090 (from geneSymbol) uc332iwv.1 uc332iwv.1 
ENSMUST00000262061.1 ENSMUSG00000124091 ENSMUST00000262061.1 ENSMUSG00000124091 (from geneSymbol) uc332ixi.1 uc332ixi.1 
ENSMUST00000262063.1 ENSMUSG00000124092 ENSMUST00000262063.1 ENSMUSG00000124092 (from geneSymbol) uc332ixk.1 uc332ixk.1 
ENSMUST00000262068.1 ENSMUSG00000124093 ENSMUST00000262068.1 ENSMUSG00000124093 (from geneSymbol) uc332ixp.1 uc332ixp.1 
ENSMUST00000262069.1 ENSMUSG00000124094 ENSMUST00000262069.1 ENSMUSG00000124094 (from geneSymbol) uc332ixq.1 uc332ixq.1 
ENSMUST00000262071.1 ENSMUSG00000124095 ENSMUST00000262071.1 ENSMUSG00000124095 (from geneSymbol) uc332ixs.1 uc332ixs.1 
ENSMUST00000262073.1 ENSMUSG00000124096 ENSMUST00000262073.1 ENSMUSG00000124096 (from geneSymbol) uc332ixu.1 uc332ixu.1 
ENSMUST00000262092.1 Gm31600 ENSMUST00000262092.1 Gm31600 (from geneSymbol) uc332iyn.1 uc332iyn.1 
ENSMUST00000262094.1 ENSMUSG00000124097 ENSMUST00000262094.1 ENSMUSG00000124097 (from geneSymbol) uc332iyp.1 uc332iyp.1 
ENSMUST00000262096.1 ENSMUSG00000124098 ENSMUST00000262096.1 ENSMUSG00000124098 (from geneSymbol) uc332iyr.1 uc332iyr.1 
ENSMUST00000262099.1 ENSMUSG00000124099 ENSMUST00000262099.1 ENSMUSG00000124099 (from geneSymbol) uc332iyu.1 uc332iyu.1 
ENSMUST00000262103.1 ENSMUSG00000124100 ENSMUST00000262103.1 ENSMUSG00000124100 (from geneSymbol) uc332iyy.1 uc332iyy.1 
ENSMUST00000262104.1 ENSMUSG00000124101 ENSMUST00000262104.1 ENSMUSG00000124101 (from geneSymbol) uc332iyz.1 uc332iyz.1 
ENSMUST00000262105.1 ENSMUSG00000124102 ENSMUST00000262105.1 ENSMUSG00000124102 (from geneSymbol) uc332iza.1 uc332iza.1 
ENSMUST00000262106.1 ENSMUSG00000124103 ENSMUST00000262106.1 ENSMUSG00000124103 (from geneSymbol) uc332izb.1 uc332izb.1 
ENSMUST00000262107.1 ENSMUSG00000124104 ENSMUST00000262107.1 ENSMUSG00000124104 (from geneSymbol) uc332izc.1 uc332izc.1 
ENSMUST00000262110.1 ENSMUSG00000124105 ENSMUST00000262110.1 ENSMUSG00000124105 (from geneSymbol) AK038730 uc332izf.1 uc332izf.1 
ENSMUST00000262112.1 ENSMUSG00000124106 ENSMUST00000262112.1 ENSMUSG00000124106 (from geneSymbol) FJ541091 uc332izh.1 uc332izh.1 
ENSMUST00000262122.1 ENSMUSG00000124107 ENSMUST00000262122.1 ENSMUSG00000124107 (from geneSymbol) AK018956 uc332izr.1 uc332izr.1 
ENSMUST00000262124.1 ENSMUSG00000124108 ENSMUST00000262124.1 ENSMUSG00000124108 (from geneSymbol) uc332izt.1 uc332izt.1 
ENSMUST00000262126.1 ENSMUSG00000124109 ENSMUST00000262126.1 ENSMUSG00000124109 (from geneSymbol) uc332izv.1 uc332izv.1 
ENSMUST00000262130.1 ENSMUSG00000124110 ENSMUST00000262130.1 ENSMUSG00000124110 (from geneSymbol) uc332izz.1 uc332izz.1 
ENSMUST00000262139.1 ENSMUSG00000124111 ENSMUST00000262139.1 ENSMUSG00000124111 (from geneSymbol) uc332jai.1 uc332jai.1 
ENSMUST00000262142.1 ENSMUSG00000124113 ENSMUST00000262142.1 ENSMUSG00000124113 (from geneSymbol) uc332jaj.1 uc332jaj.1 
ENSMUST00000262143.1 ENSMUSG00000124114 ENSMUST00000262143.1 ENSMUSG00000124114 (from geneSymbol) AK149506 uc332jak.1 uc332jak.1 
ENSMUST00000262146.1 ENSMUSG00000124115 ENSMUST00000262146.1 ENSMUSG00000124115 (from geneSymbol) KY467981 uc332jan.1 uc332jan.1 
ENSMUST00000262149.1 ENSMUSG00000124116 ENSMUST00000262149.1 ENSMUSG00000124116 (from geneSymbol) uc332jaq.1 uc332jaq.1 
ENSMUST00000262153.1 ENSMUSG00000124117 ENSMUST00000262153.1 ENSMUSG00000124117 (from geneSymbol) uc332jau.1 uc332jau.1 
ENSMUST00000262157.1 ENSMUSG00000124118 ENSMUST00000262157.1 ENSMUSG00000124118 (from geneSymbol) uc332jay.1 uc332jay.1 
ENSMUST00000262158.1 ENSMUSG00000124119 ENSMUST00000262158.1 ENSMUSG00000124119 (from geneSymbol) uc332jaz.1 uc332jaz.1 
ENSMUST00000262161.1 ENSMUSG00000124120 ENSMUST00000262161.1 ENSMUSG00000124120 (from geneSymbol) uc332jbc.1 uc332jbc.1 
ENSMUST00000262162.1 ENSMUSG00000124121 ENSMUST00000262162.1 ENSMUSG00000124121 (from geneSymbol) uc332jbd.1 uc332jbd.1 
ENSMUST00000262163.1 ENSMUSG00000124122 ENSMUST00000262163.1 ENSMUSG00000124122 (from geneSymbol) uc332jbe.1 uc332jbe.1 
ENSMUST00000262169.1 ENSMUSG00000124123 ENSMUST00000262169.1 ENSMUSG00000124123 (from geneSymbol) uc332jbh.1 uc332jbh.1 
ENSMUST00000262170.1 ENSMUSG00000124124 ENSMUST00000262170.1 ENSMUSG00000124124 (from geneSymbol) uc332jbi.1 uc332jbi.1 
ENSMUST00000262171.1 ENSMUSG00000124125 ENSMUST00000262171.1 ENSMUSG00000124125 (from geneSymbol) uc332jbj.1 uc332jbj.1 
ENSMUST00000262172.1 ENSMUSG00000124126 ENSMUST00000262172.1 ENSMUSG00000124126 (from geneSymbol) uc332jbk.1 uc332jbk.1 
ENSMUST00000262174.1 ENSMUSG00000124127 ENSMUST00000262174.1 ENSMUSG00000124127 (from geneSymbol) uc332jbm.1 uc332jbm.1 
ENSMUST00000262175.1 ENSMUSG00000124128 ENSMUST00000262175.1 ENSMUSG00000124128 (from geneSymbol) uc332jbn.1 uc332jbn.1 
ENSMUST00000262177.1 ENSMUSG00000124129 ENSMUST00000262177.1 ENSMUSG00000124129 (from geneSymbol) uc332jbp.1 uc332jbp.1 
ENSMUST00000262178.1 ENSMUSG00000124130 ENSMUST00000262178.1 ENSMUSG00000124130 (from geneSymbol) uc332jbq.1 uc332jbq.1 
ENSMUST00000262184.1 Gm28347 ENSMUST00000262184.1 Gm28347 (from geneSymbol) uc332jbw.1 uc332jbw.1 
ENSMUST00000262185.1 ENSMUSG00000124131 ENSMUST00000262185.1 ENSMUSG00000124131 (from geneSymbol) uc332jbx.1 uc332jbx.1 
ENSMUST00000262186.1 ENSMUSG00000124132 ENSMUST00000262186.1 ENSMUSG00000124132 (from geneSymbol) uc332jby.1 uc332jby.1 
ENSMUST00000262187.1 ENSMUSG00000124133 ENSMUST00000262187.1 ENSMUSG00000124133 (from geneSymbol) uc332jbz.1 uc332jbz.1 
ENSMUST00000262188.1 ENSMUSG00000124134 ENSMUST00000262188.1 ENSMUSG00000124134 (from geneSymbol) uc332jca.1 uc332jca.1 
ENSMUST00000262189.1 ENSMUSG00000124135 ENSMUST00000262189.1 ENSMUSG00000124135 (from geneSymbol) uc332jcb.1 uc332jcb.1 
ENSMUST00000262190.1 ENSMUSG00000124136 ENSMUST00000262190.1 ENSMUSG00000124136 (from geneSymbol) uc332jcc.1 uc332jcc.1 
ENSMUST00000262195.1 ENSMUSG00000124137 ENSMUST00000262195.1 ENSMUSG00000124137 (from geneSymbol) uc332jch.1 uc332jch.1 
ENSMUST00000262196.1 ENSMUSG00000124138 ENSMUST00000262196.1 ENSMUSG00000124138 (from geneSymbol) uc332jci.1 uc332jci.1 
ENSMUST00000262197.1 ENSMUSG00000124139 ENSMUST00000262197.1 ENSMUSG00000124139 (from geneSymbol) uc332jcj.1 uc332jcj.1 
ENSMUST00000262204.1 ENSMUSG00000124140 ENSMUST00000262204.1 ENSMUSG00000124140 (from geneSymbol) uc332jcq.1 uc332jcq.1 
ENSMUST00000262205.1 ENSMUSG00000124141 ENSMUST00000262205.1 ENSMUSG00000124141 (from geneSymbol) uc332jcr.1 uc332jcr.1 
ENSMUST00000262210.1 ENSMUSG00000124142 ENSMUST00000262210.1 ENSMUSG00000124142 (from geneSymbol) uc332jcw.1 uc332jcw.1 
ENSMUST00000262211.1 ENSMUSG00000124143 ENSMUST00000262211.1 ENSMUSG00000124143 (from geneSymbol) uc332jcx.1 uc332jcx.1 
ENSMUST00000262212.1 ENSMUSG00000124144 ENSMUST00000262212.1 ENSMUSG00000124144 (from geneSymbol) uc332jcy.1 uc332jcy.1 
ENSMUST00000262213.1 ENSMUSG00000124145 ENSMUST00000262213.1 ENSMUSG00000124145 (from geneSymbol) uc332jcz.1 uc332jcz.1 
ENSMUST00000262217.1 ENSMUSG00000124146 ENSMUST00000262217.1 ENSMUSG00000124146 (from geneSymbol) uc332jdd.1 uc332jdd.1 
ENSMUST00000262218.1 ENSMUSG00000124147 ENSMUST00000262218.1 ENSMUSG00000124147 (from geneSymbol) uc332jde.1 uc332jde.1 
ENSMUST00000262220.1 ENSMUSG00000124148 ENSMUST00000262220.1 predicted gene, 30712, transcript variant 2 (from RefSeq NR_168617.1) NR_168617 uc332jdg.1 uc332jdg.1 
ENSMUST00000262225.1 ENSMUSG00000124149 ENSMUST00000262225.1 ENSMUSG00000124149 (from geneSymbol) uc332jdl.1 uc332jdl.1 
ENSMUST00000262226.1 ENSMUSG00000124150 ENSMUST00000262226.1 ENSMUSG00000124150 (from geneSymbol) uc332jdm.1 uc332jdm.1 
ENSMUST00000262228.1 ENSMUSG00000124151 ENSMUST00000262228.1 ENSMUSG00000124151 (from geneSymbol) uc332jdo.1 uc332jdo.1 
ENSMUST00000262231.1 ENSMUSG00000124152 ENSMUST00000262231.1 ENSMUSG00000124152 (from geneSymbol) uc332jdr.1 uc332jdr.1 
ENSMUST00000262232.1 ENSMUSG00000124153 ENSMUST00000262232.1 ENSMUSG00000124153 (from geneSymbol) uc332jds.1 uc332jds.1 
ENSMUST00000262233.1 ENSMUSG00000124154 ENSMUST00000262233.1 ENSMUSG00000124154 (from geneSymbol) uc332jdt.1 uc332jdt.1 
ENSMUST00000262234.1 ENSMUSG00000124155 ENSMUST00000262234.1 ENSMUSG00000124155 (from geneSymbol) uc332jdu.1 uc332jdu.1 
ENSMUST00000262235.1 ENSMUSG00000124156 ENSMUST00000262235.1 ENSMUSG00000124156 (from geneSymbol) uc332jdv.1 uc332jdv.1 
ENSMUST00000262240.1 ENSMUSG00000124157 ENSMUST00000262240.1 ENSMUSG00000124157 (from geneSymbol) uc332jea.1 uc332jea.1 
ENSMUST00000262241.1 ENSMUSG00000124158 ENSMUST00000262241.1 ENSMUSG00000124158 (from geneSymbol) uc332jeb.1 uc332jeb.1 
ENSMUST00000262242.1 ENSMUSG00000124159 ENSMUST00000262242.1 ENSMUSG00000124159 (from geneSymbol) uc332jec.1 uc332jec.1 
ENSMUST00000262243.1 ENSMUSG00000124160 ENSMUST00000262243.1 ENSMUSG00000124160 (from geneSymbol) uc332jed.1 uc332jed.1 
ENSMUST00000262248.1 ENSMUSG00000124161 ENSMUST00000262248.1 ENSMUSG00000124161 (from geneSymbol) uc332jei.1 uc332jei.1 
ENSMUST00000262250.1 ENSMUSG00000124162 ENSMUST00000262250.1 ENSMUSG00000124162 (from geneSymbol) uc332jek.1 uc332jek.1 
ENSMUST00000262251.1 ENSMUSG00000124163 ENSMUST00000262251.1 ENSMUSG00000124163 (from geneSymbol) uc332jel.1 uc332jel.1 
ENSMUST00000262252.1 ENSMUSG00000124164 ENSMUST00000262252.1 ENSMUSG00000124164 (from geneSymbol) uc332jem.1 uc332jem.1 
ENSMUST00000262253.1 ENSMUSG00000124165 ENSMUST00000262253.1 ENSMUSG00000124165 (from geneSymbol) uc332jen.1 uc332jen.1 
ENSMUST00000262257.1 ENSMUSG00000124166 ENSMUST00000262257.1 ENSMUSG00000124166 (from geneSymbol) uc332jer.1 uc332jer.1 
ENSMUST00000262260.1 ENSMUSG00000124167 ENSMUST00000262260.1 ENSMUSG00000124167 (from geneSymbol) uc332jeu.1 uc332jeu.1 
ENSMUST00000262261.1 ENSMUSG00000124168 ENSMUST00000262261.1 ENSMUSG00000124168 (from geneSymbol) uc332jev.1 uc332jev.1 
ENSMUST00000262262.1 ENSMUSG00000124169 ENSMUST00000262262.1 ENSMUSG00000124169 (from geneSymbol) uc332jew.1 uc332jew.1 
ENSMUST00000262279.1 Cypt14-ps ENSMUST00000262279.1 Cypt14-ps (from geneSymbol) BC099555 uc332jfn.1 uc332jfn.1 
ENSMUST00000262289.1 ENSMUSG00000124170 ENSMUST00000262289.1 ENSMUSG00000124170 (from geneSymbol) LF199333 uc332jfx.1 uc332jfx.1 
ENSMUST00000262290.1 ENSMUSG00000124171 ENSMUST00000262290.1 ENSMUSG00000124171 (from geneSymbol) uc332jfy.1 uc332jfy.1 
ENSMUST00000262291.1 ENSMUSG00000124172 ENSMUST00000262291.1 ENSMUSG00000124172 (from geneSymbol) uc332jfz.1 uc332jfz.1 
ENSMUST00000262292.1 ENSMUSG00000124173 ENSMUST00000262292.1 ENSMUSG00000124173 (from geneSymbol) uc332jga.1 uc332jga.1 
ENSMUST00000262294.1 ENSMUSG00000124174 ENSMUST00000262294.1 ENSMUSG00000124174 (from geneSymbol) uc332jgc.1 uc332jgc.1 
ENSMUST00000262295.1 ENSMUSG00000124175 ENSMUST00000262295.1 ENSMUSG00000124175 (from geneSymbol) uc332jgd.1 uc332jgd.1 
ENSMUST00000262297.1 ENSMUSG00000124176 ENSMUST00000262297.1 ENSMUSG00000124176 (from geneSymbol) uc332jgf.1 uc332jgf.1 
ENSMUST00000262298.1 ENSMUSG00000124177 ENSMUST00000262298.1 ENSMUSG00000124177 (from geneSymbol) uc332jgg.1 uc332jgg.1 
ENSMUST00000262301.1 ENSMUSG00000124179 ENSMUST00000262301.1 ENSMUSG00000124179 (from geneSymbol) uc332jgi.1 uc332jgi.1 
ENSMUST00000262305.1 ENSMUSG00000124180 ENSMUST00000262305.1 ENSMUSG00000124180 (from geneSymbol) uc332jgm.1 uc332jgm.1 
ENSMUST00000262375.1 ENSMUSG00000124181 ENSMUST00000262375.1 ENSMUSG00000124181 (from geneSymbol) uc332jje.1 uc332jje.1 
ENSMUST00000262380.1 ENSMUSG00000124182 ENSMUST00000262380.1 ENSMUSG00000124182 (from geneSymbol) uc332jjj.1 uc332jjj.1 
ENSMUST00000262381.1 ENSMUSG00000124183 ENSMUST00000262381.1 ENSMUSG00000124183 (from geneSymbol) uc332jjk.1 uc332jjk.1 
ENSMUST00000262384.1 ENSMUSG00000124184 ENSMUST00000262384.1 ENSMUSG00000124184 (from geneSymbol) uc332jjn.1 uc332jjn.1 
ENSMUST00000262394.1 ENSMUSG00000124185 ENSMUST00000262394.1 ENSMUSG00000124185 (from geneSymbol) uc332jjx.1 uc332jjx.1 
ENSMUST00000262399.1 ENSMUSG00000124186 ENSMUST00000262399.1 ENSMUSG00000124186 (from geneSymbol) uc332jkc.1 uc332jkc.1 
ENSMUST00000262407.1 ENSMUSG00000124187 ENSMUST00000262407.1 ENSMUSG00000124187 (from geneSymbol) uc332jkk.1 uc332jkk.1 
ENSMUST00000262433.1 ENSMUSG00000124188 ENSMUST00000262433.1 ENSMUSG00000124188 (from geneSymbol) uc332jlk.1 uc332jlk.1 
ENSMUST00000262434.1 ENSMUSG00000124189 ENSMUST00000262434.1 ENSMUSG00000124189 (from geneSymbol) uc332jll.1 uc332jll.1 
ENSMUST00000262435.1 ENSMUSG00000124190 ENSMUST00000262435.1 ENSMUSG00000124190 (from geneSymbol) uc332jlm.1 uc332jlm.1 
ENSMUST00000262436.1 ENSMUSG00000124191 ENSMUST00000262436.1 ENSMUSG00000124191 (from geneSymbol) uc332jln.1 uc332jln.1 
ENSMUST00000262437.1 ENSMUSG00000124192 ENSMUST00000262437.1 ENSMUSG00000124192 (from geneSymbol) uc332jlo.1 uc332jlo.1 
ENSMUST00000262457.1 ENSMUSG00000124193 ENSMUST00000262457.1 ENSMUSG00000124193 (from geneSymbol) uc332jmi.1 uc332jmi.1 
ENSMUST00000262460.1 ENSMUSG00000124194 ENSMUST00000262460.1 ENSMUSG00000124194 (from geneSymbol) uc332jml.1 uc332jml.1 
ENSMUST00000262464.1 Gm47680 ENSMUST00000262464.1 Gm47680 (from geneSymbol) uc332jmp.1 uc332jmp.1 
ENSMUST00000262487.1 ENSMUSG00000124195 ENSMUST00000262487.1 ENSMUSG00000124195 (from geneSymbol) uc332jnm.1 uc332jnm.1 
ENSMUST00000262488.1 ENSMUSG00000124196 ENSMUST00000262488.1 ENSMUSG00000124196 (from geneSymbol) uc332jnn.1 uc332jnn.1 
ENSMUST00000262489.1 ENSMUSG00000124197 ENSMUST00000262489.1 ENSMUSG00000124197 (from geneSymbol) uc332jno.1 uc332jno.1 
ENSMUST00000262491.1 ENSMUSG00000124198 ENSMUST00000262491.1 ENSMUSG00000124198 (from geneSymbol) uc332jnq.1 uc332jnq.1 
ENSMUST00000262492.1 ENSMUSG00000124199 ENSMUST00000262492.1 ENSMUSG00000124199 (from geneSymbol) uc332jnr.1 uc332jnr.1 
ENSMUST00000262495.1 ENSMUSG00000124200 ENSMUST00000262495.1 ENSMUSG00000124200 (from geneSymbol) uc332jnu.1 uc332jnu.1 
ENSMUST00000262496.1 ENSMUSG00000124201 ENSMUST00000262496.1 ENSMUSG00000124201 (from geneSymbol) uc332jnv.1 uc332jnv.1 
ENSMUST00000262500.1 ENSMUSG00000124202 ENSMUST00000262500.1 ENSMUSG00000124202 (from geneSymbol) uc332jnz.1 uc332jnz.1 
ENSMUST00000262502.1 ENSMUSG00000124203 ENSMUST00000262502.1 ENSMUSG00000124203 (from geneSymbol) uc332job.1 uc332job.1 
ENSMUST00000262503.1 4930529I22Rik ENSMUST00000262503.1 4930529I22Rik (from geneSymbol) AK015936 uc332joc.1 uc332joc.1 
ENSMUST00000262509.1 ENSMUSG00000124204 ENSMUST00000262509.1 ENSMUSG00000124204 (from geneSymbol) uc332joi.1 uc332joi.1 
ENSMUST00000262521.1 ENSMUSG00000124205 ENSMUST00000262521.1 ENSMUSG00000124205 (from geneSymbol) uc332jou.1 uc332jou.1 
ENSMUST00000262524.1 Gm50255 ENSMUST00000262524.1 Gm50255 (from geneSymbol) uc332jox.1 uc332jox.1 
ENSMUST00000262527.1 ENSMUSG00000124206 ENSMUST00000262527.1 ENSMUSG00000124206 (from geneSymbol) uc332jpa.1 uc332jpa.1 
ENSMUST00000262529.1 ENSMUSG00000124207 ENSMUST00000262529.1 ENSMUSG00000124207 (from geneSymbol) uc332jpc.1 uc332jpc.1 
ENSMUST00000262531.1 ENSMUSG00000124208 ENSMUST00000262531.1 ENSMUSG00000124208 (from geneSymbol) LF197380 uc332jpe.1 uc332jpe.1 
ENSMUST00000262533.1 ENSMUSG00000124209 ENSMUST00000262533.1 ENSMUSG00000124209 (from geneSymbol) uc332jpg.1 uc332jpg.1 
ENSMUST00000262535.1 ENSMUSG00000124210 ENSMUST00000262535.1 ENSMUSG00000124210 (from geneSymbol) uc332jpi.1 uc332jpi.1 
ENSMUST00000262536.1 ENSMUSG00000124211 ENSMUST00000262536.1 ENSMUSG00000124211 (from geneSymbol) uc332jpj.1 uc332jpj.1 
ENSMUST00000262539.1 ENSMUSG00000124212 ENSMUST00000262539.1 ENSMUSG00000124212 (from geneSymbol) uc332jpm.1 uc332jpm.1 
ENSMUST00000262540.1 ENSMUSG00000124213 ENSMUST00000262540.1 ENSMUSG00000124213 (from geneSymbol) uc332jpn.1 uc332jpn.1 
ENSMUST00000262542.1 ENSMUSG00000124214 ENSMUST00000262542.1 ENSMUSG00000124214 (from geneSymbol) uc332jpp.1 uc332jpp.1 
ENSMUST00000262544.1 ENSMUSG00000124215 ENSMUST00000262544.1 ENSMUSG00000124215 (from geneSymbol) uc332jpr.1 uc332jpr.1 
ENSMUST00000262549.1 ENSMUSG00000124216 ENSMUST00000262549.1 ENSMUSG00000124216 (from geneSymbol) uc332jpw.1 uc332jpw.1 
ENSMUST00000262552.1 ENSMUSG00000124217 ENSMUST00000262552.1 ENSMUSG00000124217 (from geneSymbol) uc332jpz.1 uc332jpz.1 
ENSMUST00000262555.1 Gm17032 ENSMUST00000262555.1 Gm17032 (from geneSymbol) uc332jqc.1 uc332jqc.1 
ENSMUST00000262558.1 ENSMUSG00000124218 ENSMUST00000262558.1 ENSMUSG00000124218 (from geneSymbol) uc332jqf.1 uc332jqf.1 
ENSMUST00000262559.1 ENSMUSG00000124219 ENSMUST00000262559.1 ENSMUSG00000124219 (from geneSymbol) uc332jqg.1 uc332jqg.1 
ENSMUST00000262560.1 ENSMUSG00000124220 ENSMUST00000262560.1 ENSMUSG00000124220 (from geneSymbol) uc332jqh.1 uc332jqh.1 
ENSMUST00000262566.1 ENSMUSG00000124221 ENSMUST00000262566.1 ENSMUSG00000124221 (from geneSymbol) uc332jqn.1 uc332jqn.1 
ENSMUST00000262572.1 ENSMUSG00000124222 ENSMUST00000262572.1 ENSMUSG00000124222 (from geneSymbol) uc332jqt.1 uc332jqt.1 
ENSMUST00000262574.1 ENSMUSG00000124223 ENSMUST00000262574.1 ENSMUSG00000124223 (from geneSymbol) uc332jqv.1 uc332jqv.1 
ENSMUST00000262588.1 ENSMUSG00000124224 ENSMUST00000262588.1 ENSMUSG00000124224 (from geneSymbol) uc332jrj.1 uc332jrj.1 
ENSMUST00000262589.1 ENSMUSG00000124225 ENSMUST00000262589.1 ENSMUSG00000124225 (from geneSymbol) uc332jrk.1 uc332jrk.1 
ENSMUST00000262590.1 ENSMUSG00000124226 ENSMUST00000262590.1 ENSMUSG00000124226 (from geneSymbol) uc332jrl.1 uc332jrl.1 
ENSMUST00000262592.1 ENSMUSG00000124228 ENSMUST00000262592.1 ENSMUSG00000124228 (from geneSymbol) uc332jrm.1 uc332jrm.1 
ENSMUST00000262594.1 ENSMUSG00000124229 ENSMUST00000262594.1 ENSMUSG00000124229 (from geneSymbol) uc332jro.1 uc332jro.1 
ENSMUST00000262617.1 4930570N18Rik ENSMUST00000262617.1 4930570N18Rik (from geneSymbol) AK019800 uc332jsl.1 uc332jsl.1 
ENSMUST00000262621.1 Gm34022 ENSMUST00000262621.1 Gm34022 (from geneSymbol) uc332jsp.1 uc332jsp.1 
ENSMUST00000262677.1 ENSMUSG00000124230 ENSMUST00000262677.1 ENSMUSG00000124230 (from geneSymbol) uc332jut.1 uc332jut.1 
ENSMUST00000262681.1 ENSMUSG00000124231 ENSMUST00000262681.1 ENSMUSG00000124231 (from geneSymbol) uc332juw.1 uc332juw.1 
ENSMUST00000262685.1 ENSMUSG00000124232 ENSMUST00000262685.1 ENSMUSG00000124232 (from geneSymbol) AK037643 uc332jva.1 uc332jva.1 
ENSMUST00000262687.1 ENSMUSG00000124233 ENSMUST00000262687.1 ENSMUSG00000124233 (from geneSymbol) uc332jvc.1 uc332jvc.1 
ENSMUST00000262694.1 ENSMUSG00000124234 ENSMUST00000262694.1 ENSMUSG00000124234 (from geneSymbol) uc332jvj.1 uc332jvj.1 
ENSMUST00000262696.1 ENSMUSG00000124235 ENSMUST00000262696.1 ENSMUSG00000124235 (from geneSymbol) uc332jvl.1 uc332jvl.1 
ENSMUST00000262697.1 ENSMUSG00000124236 ENSMUST00000262697.1 ENSMUSG00000124236 (from geneSymbol) uc332jvm.1 uc332jvm.1 
ENSMUST00000262698.1 ENSMUSG00000124237 ENSMUST00000262698.1 ENSMUSG00000124237 (from geneSymbol) uc332jvn.1 uc332jvn.1 
ENSMUST00000262699.1 ENSMUSG00000124238 ENSMUST00000262699.1 ENSMUSG00000124238 (from geneSymbol) uc332jvo.1 uc332jvo.1 
ENSMUST00000262700.1 ENSMUSG00000124239 ENSMUST00000262700.1 ENSMUSG00000124239 (from geneSymbol) uc332jvp.1 uc332jvp.1 
ENSMUST00000262702.1 ENSMUSG00000124240 ENSMUST00000262702.1 ENSMUSG00000124240 (from geneSymbol) uc332jvr.1 uc332jvr.1 
ENSMUST00000262703.1 ENSMUSG00000124241 ENSMUST00000262703.1 ENSMUSG00000124241 (from geneSymbol) uc332jvs.1 uc332jvs.1 
ENSMUST00000262706.1 ENSMUSG00000124242 ENSMUST00000262706.1 ENSMUSG00000124242 (from geneSymbol) uc332jvv.1 uc332jvv.1 
ENSMUST00000262707.1 ENSMUSG00000124243 ENSMUST00000262707.1 ENSMUSG00000124243 (from geneSymbol) uc332jvw.1 uc332jvw.1 
ENSMUST00000262709.1 Gm15567 ENSMUST00000262709.1 Gm15567 (from geneSymbol) AK042797 uc332jvy.1 uc332jvy.1 
ENSMUST00000262714.1 ENSMUSG00000124244 ENSMUST00000262714.1 ENSMUSG00000124244 (from geneSymbol) uc332jwd.1 uc332jwd.1 
ENSMUST00000262719.1 ENSMUSG00000124245 ENSMUST00000262719.1 ENSMUSG00000124245 (from geneSymbol) uc332jwi.1 uc332jwi.1 
ENSMUST00000262733.1 ENSMUSG00000124246 ENSMUST00000262733.1 ENSMUSG00000124246 (from geneSymbol) uc332jww.1 uc332jww.1 
ENSMUST00000262735.1 ENSMUSG00000124247 ENSMUST00000262735.1 ENSMUSG00000124247 (from geneSymbol) uc332jwy.1 uc332jwy.1 
ENSMUST00000262738.1 ENSMUSG00000124248 ENSMUST00000262738.1 ENSMUSG00000124248 (from geneSymbol) uc332jxb.1 uc332jxb.1 
ENSMUST00000262740.1 ENSMUSG00000124249 ENSMUST00000262740.1 ENSMUSG00000124249 (from geneSymbol) uc332jxd.1 uc332jxd.1 
ENSMUST00000262741.1 1700064N11Rik ENSMUST00000262741.1 1700064N11Rik (from geneSymbol) uc332jxe.1 uc332jxe.1 
ENSMUST00000262744.1 ENSMUSG00000124250 ENSMUST00000262744.1 ENSMUSG00000124250 (from geneSymbol) uc332jxh.1 uc332jxh.1 
ENSMUST00000262756.1 ENSMUSG00000124251 ENSMUST00000262756.1 ENSMUSG00000124251 (from geneSymbol) uc332jxt.1 uc332jxt.1 
ENSMUST00000262759.1 ENSMUSG00000124252 ENSMUST00000262759.1 ENSMUSG00000124252 (from geneSymbol) uc332jxw.1 uc332jxw.1 
ENSMUST00000262761.1 ENSMUSG00000124253 ENSMUST00000262761.1 ENSMUSG00000124253 (from geneSymbol) uc332jxy.1 uc332jxy.1 
ENSMUST00000262762.1 Gm12472 ENSMUST00000262762.1 Gm12472 (from geneSymbol) AK041215 uc332jxz.1 uc332jxz.1 
ENSMUST00000262766.1 Gm20556 ENSMUST00000262766.1 Gm20556 (from geneSymbol) AK079813 uc332jyd.1 uc332jyd.1 
ENSMUST00000262770.1 ENSMUSG00000124255 ENSMUST00000262770.1 ENSMUSG00000124255 (from geneSymbol) uc332jyg.1 uc332jyg.1 
ENSMUST00000262773.1 Gm17751 ENSMUST00000262773.1 Gm17751 (from geneSymbol) uc332jyj.1 uc332jyj.1 
ENSMUST00000262774.1 Gm43091 ENSMUST00000262774.1 Gm43091 (from geneSymbol) uc332jyk.1 uc332jyk.1 
ENSMUST00000262776.1 ENSMUSG00000124256 ENSMUST00000262776.1 ENSMUSG00000124256 (from geneSymbol) uc332jym.1 uc332jym.1 
ENSMUST00000262777.1 ENSMUSG00000124257 ENSMUST00000262777.1 ENSMUSG00000124257 (from geneSymbol) uc332jyn.1 uc332jyn.1 
ENSMUST00000262780.1 ENSMUSG00000124258 ENSMUST00000262780.1 ENSMUSG00000124258 (from geneSymbol) uc332jyq.1 uc332jyq.1 
ENSMUST00000262781.1 Gm13175 ENSMUST00000262781.1 Gm13175 (from geneSymbol) uc332jyr.1 uc332jyr.1 
ENSMUST00000262783.1 ENSMUSG00000124259 ENSMUST00000262783.1 ENSMUSG00000124259 (from geneSymbol) BC061201 uc332jyt.1 uc332jyt.1 
ENSMUST00000262784.1 ENSMUSG00000124260 ENSMUST00000262784.1 ENSMUSG00000124260 (from geneSymbol) uc332jyu.1 uc332jyu.1 
ENSMUST00000262791.1 Gm13832 ENSMUST00000262791.1 Gm13832 (from geneSymbol) uc332jzb.1 uc332jzb.1 
ENSMUST00000262801.1 3300002A11Rik ENSMUST00000262801.1 3300002A11Rik (from geneSymbol) AK014365 uc332jzl.1 uc332jzl.1 
ENSMUST00000262805.1 ENSMUSG00000124261 ENSMUST00000262805.1 ENSMUSG00000124261 (from geneSymbol) uc332jzp.1 uc332jzp.1 
ENSMUST00000262808.1 ENSMUSG00000124262 ENSMUST00000262808.1 ENSMUSG00000124262 (from geneSymbol) uc332jzs.1 uc332jzs.1 
ENSMUST00000262809.1 ENSMUSG00000124263 ENSMUST00000262809.1 ENSMUSG00000124263 (from geneSymbol) uc332jzt.1 uc332jzt.1 
ENSMUST00000262811.1 ENSMUSG00000124264 ENSMUST00000262811.1 ENSMUSG00000124264 (from geneSymbol) uc332jzv.1 uc332jzv.1 
ENSMUST00000262812.1 ENSMUSG00000124265 ENSMUST00000262812.1 ENSMUSG00000124265 (from geneSymbol) uc332jzw.1 uc332jzw.1 
ENSMUST00000262814.1 ENSMUSG00000124266 ENSMUST00000262814.1 ENSMUSG00000124266 (from geneSymbol) uc332jzy.1 uc332jzy.1 
ENSMUST00000262816.1 ENSMUSG00000124267 ENSMUST00000262816.1 ENSMUSG00000124267 (from geneSymbol) uc332kaa.1 uc332kaa.1 
ENSMUST00000262818.1 ENSMUSG00000124268 ENSMUST00000262818.1 ENSMUSG00000124268 (from geneSymbol) uc332kac.1 uc332kac.1 
ENSMUST00000262828.1 ENSMUSG00000124269 ENSMUST00000262828.1 ENSMUSG00000124269 (from geneSymbol) uc332kam.1 uc332kam.1 
ENSMUST00000262838.1 ENSMUSG00000124270 ENSMUST00000262838.1 ENSMUSG00000124270 (from geneSymbol) uc332kaw.1 uc332kaw.1 
ENSMUST00000262839.1 Gm12434 ENSMUST00000262839.1 Gm12434 (from geneSymbol) AK133250 uc332kax.1 uc332kax.1 
ENSMUST00000262844.1 ENSMUSG00000124271 ENSMUST00000262844.1 ENSMUSG00000124271 (from geneSymbol) uc332kbc.1 uc332kbc.1 
ENSMUST00000262845.1 ENSMUSG00000124272 ENSMUST00000262845.1 ENSMUSG00000124272 (from geneSymbol) uc332kbd.1 uc332kbd.1 
ENSMUST00000262846.1 Gm34894 ENSMUST00000262846.1 Gm34894 (from geneSymbol) KY467638 uc332kbe.1 uc332kbe.1 
ENSMUST00000262857.1 ENSMUSG00000124273 ENSMUST00000262857.1 ENSMUSG00000124273 (from geneSymbol) uc332kbp.1 uc332kbp.1 
ENSMUST00000262859.1 ENSMUSG00000124274 ENSMUST00000262859.1 ENSMUSG00000124274 (from geneSymbol) uc332kbr.1 uc332kbr.1 
ENSMUST00000262864.1 ENSMUSG00000124275 ENSMUST00000262864.1 ENSMUSG00000124275 (from geneSymbol) uc332kbw.1 uc332kbw.1 
ENSMUST00000262868.1 ENSMUSG00000124276 ENSMUST00000262868.1 ENSMUSG00000124276 (from geneSymbol) uc332kca.1 uc332kca.1 
ENSMUST00000262869.1 C130073E24Rik ENSMUST00000262869.1 C130073E24Rik (from geneSymbol) uc332kcb.1 uc332kcb.1 
ENSMUST00000262886.1 ENSMUSG00000124277 ENSMUST00000262886.1 ENSMUSG00000124277 (from geneSymbol) uc332kcs.1 uc332kcs.1 
ENSMUST00000262887.1 ENSMUSG00000124278 ENSMUST00000262887.1 ENSMUSG00000124278 (from geneSymbol) uc332kct.1 uc332kct.1 
ENSMUST00000262888.1 ENSMUSG00000124279 ENSMUST00000262888.1 ENSMUSG00000124279 (from geneSymbol) uc332kcu.1 uc332kcu.1 
ENSMUST00000262889.1 ENSMUSG00000124280 ENSMUST00000262889.1 ENSMUSG00000124280 (from geneSymbol) uc332kcv.1 uc332kcv.1 
ENSMUST00000262890.1 ENSMUSG00000124281 ENSMUST00000262890.1 ENSMUSG00000124281 (from geneSymbol) uc332kcw.1 uc332kcw.1 
ENSMUST00000262892.1 ENSMUSG00000124282 ENSMUST00000262892.1 ENSMUSG00000124282 (from geneSymbol) uc332kcy.1 uc332kcy.1 
ENSMUST00000262893.1 Gm48526 ENSMUST00000262893.1 Gm48526 (from geneSymbol) uc332kcz.1 uc332kcz.1 
ENSMUST00000262895.1 ENSMUSG00000124283 ENSMUST00000262895.1 ENSMUSG00000124283 (from geneSymbol) uc332kdb.1 uc332kdb.1 
ENSMUST00000262896.1 9230109A22Rik ENSMUST00000262896.1 9230109A22Rik (from geneSymbol) AK039160 uc332kdc.1 uc332kdc.1 
ENSMUST00000262908.1 Gm48508 ENSMUST00000262908.1 Gm48508 (from geneSymbol) uc332kdo.1 uc332kdo.1 
ENSMUST00000262914.1 ENSMUSG00000124284 ENSMUST00000262914.1 ENSMUSG00000124284 (from geneSymbol) uc332kdu.1 uc332kdu.1 
ENSMUST00000262916.1 ENSMUSG00000124285 ENSMUST00000262916.1 ENSMUSG00000124285 (from geneSymbol) uc332kdw.1 uc332kdw.1 
ENSMUST00000262918.1 ENSMUSG00000124286 ENSMUST00000262918.1 ENSMUSG00000124286 (from geneSymbol) uc332kdy.1 uc332kdy.1 
ENSMUST00000262922.1 ENSMUSG00000124287 ENSMUST00000262922.1 ENSMUSG00000124287 (from geneSymbol) uc332keb.1 uc332keb.1 
ENSMUST00000262926.1 ENSMUSG00000124288 ENSMUST00000262926.1 ENSMUSG00000124288 (from geneSymbol) uc332kee.1 uc332kee.1 
ENSMUST00000262928.1 ENSMUSG00000124289 ENSMUST00000262928.1 ENSMUSG00000124289 (from geneSymbol) uc332keg.1 uc332keg.1 
ENSMUST00000262929.1 ENSMUSG00000124290 ENSMUST00000262929.1 ENSMUSG00000124290 (from geneSymbol) uc332keh.1 uc332keh.1 
ENSMUST00000262931.1 ENSMUSG00000124291 ENSMUST00000262931.1 ENSMUSG00000124291 (from geneSymbol) uc332kej.1 uc332kej.1 
ENSMUST00000262932.1 ENSMUSG00000124292 ENSMUST00000262932.1 ENSMUSG00000124292 (from geneSymbol) uc332kek.1 uc332kek.1 
ENSMUST00000262935.1 ENSMUSG00000124293 ENSMUST00000262935.1 ENSMUSG00000124293 (from geneSymbol) uc332ken.1 uc332ken.1 
ENSMUST00000262938.1 ENSMUSG00000124294 ENSMUST00000262938.1 ENSMUSG00000124294 (from geneSymbol) uc332keq.1 uc332keq.1 
ENSMUST00000262939.1 ENSMUSG00000124295 ENSMUST00000262939.1 ENSMUSG00000124295 (from geneSymbol) uc332ker.1 uc332ker.1 
ENSMUST00000262942.1 ENSMUSG00000124296 ENSMUST00000262942.1 ENSMUSG00000124296 (from geneSymbol) uc332keu.1 uc332keu.1 
ENSMUST00000262944.1 ENSMUSG00000124297 ENSMUST00000262944.1 ENSMUSG00000124297 (from geneSymbol) uc332kew.1 uc332kew.1 
ENSMUST00000262947.1 ENSMUSG00000124298 ENSMUST00000262947.1 ENSMUSG00000124298 (from geneSymbol) uc332kez.1 uc332kez.1 
ENSMUST00000262948.1 ENSMUSG00000124299 ENSMUST00000262948.1 ENSMUSG00000124299 (from geneSymbol) uc332kfa.1 uc332kfa.1 
ENSMUST00000262949.1 ENSMUSG00000124300 ENSMUST00000262949.1 ENSMUSG00000124300 (from geneSymbol) uc332kfb.1 uc332kfb.1 
ENSMUST00000262953.1 ENSMUSG00000124301 ENSMUST00000262953.1 ENSMUSG00000124301 (from geneSymbol) uc332kff.1 uc332kff.1 
ENSMUST00000262954.1 ENSMUSG00000124302 ENSMUST00000262954.1 ENSMUSG00000124302 (from geneSymbol) uc332kfg.1 uc332kfg.1 
ENSMUST00000262955.1 ENSMUSG00000124303 ENSMUST00000262955.1 ENSMUSG00000124303 (from geneSymbol) uc332kfh.1 uc332kfh.1 
ENSMUST00000262957.1 ENSMUSG00000124304 ENSMUST00000262957.1 ENSMUSG00000124304 (from geneSymbol) uc332kfj.1 uc332kfj.1 
ENSMUST00000262971.1 ENSMUSG00000124305 ENSMUST00000262971.1 ENSMUSG00000124305 (from geneSymbol) uc332kfx.1 uc332kfx.1 
ENSMUST00000262997.1 Gm30409 ENSMUST00000262997.1 Gm30409 (from geneSymbol) uc332kgx.1 uc332kgx.1 
ENSMUST00000263003.1 2610027F03Rik ENSMUST00000263003.1 2610027F03Rik (from geneSymbol) AK011565 uc332khc.1 uc332khc.1 
ENSMUST00000263009.1 ENSMUSG00000124306 ENSMUST00000263009.1 ENSMUSG00000124306 (from geneSymbol) uc332khi.1 uc332khi.1 
ENSMUST00000263015.1 ENSMUSG00000124307 ENSMUST00000263015.1 ENSMUSG00000124307 (from geneSymbol) uc332kho.1 uc332kho.1 
ENSMUST00000263017.1 ENSMUSG00000124308 ENSMUST00000263017.1 ENSMUSG00000124308 (from geneSymbol) uc332khq.1 uc332khq.1 
ENSMUST00000263018.1 ENSMUSG00000124309 ENSMUST00000263018.1 ENSMUSG00000124309 (from geneSymbol) uc332khr.1 uc332khr.1 
ENSMUST00000263019.1 ENSMUSG00000124310 ENSMUST00000263019.1 ENSMUSG00000124310 (from geneSymbol) uc332khs.1 uc332khs.1 
ENSMUST00000263030.1 Gm13021 ENSMUST00000263030.1 Gm13021 (from geneSymbol) KY468027 uc332kid.1 uc332kid.1 
ENSMUST00000263070.1 ENSMUSG00000124311 ENSMUST00000263070.1 ENSMUSG00000124311 (from geneSymbol) uc332kjr.1 uc332kjr.1 
ENSMUST00000263072.1 ENSMUSG00000124312 ENSMUST00000263072.1 ENSMUSG00000124312 (from geneSymbol) uc332kjt.1 uc332kjt.1 
ENSMUST00000263074.1 ENSMUSG00000124313 ENSMUST00000263074.1 ENSMUSG00000124313 (from geneSymbol) uc332kjv.1 uc332kjv.1 
ENSMUST00000263075.1 ENSMUSG00000124314 ENSMUST00000263075.1 ENSMUSG00000124314 (from geneSymbol) uc332kjw.1 uc332kjw.1 
ENSMUST00000263080.1 ENSMUSG00000124315 ENSMUST00000263080.1 ENSMUSG00000124315 (from geneSymbol) uc332kkb.1 uc332kkb.1 
ENSMUST00000263082.1 ENSMUSG00000124316 ENSMUST00000263082.1 ENSMUSG00000124316 (from geneSymbol) uc332kkd.1 uc332kkd.1 
ENSMUST00000263083.1 ENSMUSG00000124317 ENSMUST00000263083.1 ENSMUSG00000124317 (from geneSymbol) uc332kke.1 uc332kke.1 
ENSMUST00000263100.1 ENSMUSG00000124318 ENSMUST00000263100.1 ENSMUSG00000124318 (from geneSymbol) uc332kkv.1 uc332kkv.1 
ENSMUST00000263104.1 ENSMUSG00000124319 ENSMUST00000263104.1 ENSMUSG00000124319 (from geneSymbol) uc332kkz.1 uc332kkz.1 
ENSMUST00000263107.1 ENSMUSG00000124320 ENSMUST00000263107.1 ENSMUSG00000124320 (from geneSymbol) uc332klc.1 uc332klc.1 
ENSMUST00000263108.1 ENSMUSG00000124321 ENSMUST00000263108.1 ENSMUSG00000124321 (from geneSymbol) uc332kld.1 uc332kld.1 
ENSMUST00000263110.1 ENSMUSG00000124322 ENSMUST00000263110.1 ENSMUSG00000124322 (from geneSymbol) uc332klf.1 uc332klf.1 
ENSMUST00000263112.1 ENSMUSG00000124323 ENSMUST00000263112.1 ENSMUSG00000124323 (from geneSymbol) uc332klh.1 uc332klh.1 
ENSMUST00000263114.1 ENSMUSG00000124324 ENSMUST00000263114.1 ENSMUSG00000124324 (from geneSymbol) uc332klj.1 uc332klj.1 
ENSMUST00000263116.1 4930433J02Rik ENSMUST00000263116.1 4930433J02Rik (from geneSymbol) AK015304 uc332kll.1 uc332kll.1 
ENSMUST00000263127.1 ENSMUSG00000124325 ENSMUST00000263127.1 ENSMUSG00000124325 (from geneSymbol) uc332klw.1 uc332klw.1 
ENSMUST00000263129.1 ENSMUSG00000124326 ENSMUST00000263129.1 ENSMUSG00000124326 (from geneSymbol) uc332kly.1 uc332kly.1 
ENSMUST00000263130.1 ENSMUSG00000124327 ENSMUST00000263130.1 ENSMUSG00000124327 (from geneSymbol) uc332klz.1 uc332klz.1 
ENSMUST00000263132.1 ENSMUSG00000124328 ENSMUST00000263132.1 ENSMUSG00000124328 (from geneSymbol) uc332kmb.1 uc332kmb.1 
ENSMUST00000263133.1 ENSMUSG00000124329 ENSMUST00000263133.1 ENSMUSG00000124329 (from geneSymbol) uc332kmc.1 uc332kmc.1 
ENSMUST00000263135.1 ENSMUSG00000124330 ENSMUST00000263135.1 ENSMUSG00000124330 (from geneSymbol) uc332kme.1 uc332kme.1 
ENSMUST00000263136.1 ENSMUSG00000124331 ENSMUST00000263136.1 ENSMUSG00000124331 (from geneSymbol) uc332kmf.1 uc332kmf.1 
ENSMUST00000263141.1 ENSMUSG00000124332 ENSMUST00000263141.1 ENSMUSG00000124332 (from geneSymbol) uc332kmk.1 uc332kmk.1 
ENSMUST00000263142.1 ENSMUSG00000124333 ENSMUST00000263142.1 ENSMUSG00000124333 (from geneSymbol) uc332kml.1 uc332kml.1 
ENSMUST00000263143.1 ENSMUSG00000124334 ENSMUST00000263143.1 ENSMUSG00000124334 (from geneSymbol) uc332kmm.1 uc332kmm.1 
ENSMUST00000263144.1 ENSMUSG00000124335 ENSMUST00000263144.1 ENSMUSG00000124335 (from geneSymbol) uc332kmn.1 uc332kmn.1 
ENSMUST00000263146.1 Gm8630 ENSMUST00000263146.1 predicted gene 8630 (from RefSeq NR_152176.1) NR_152176 uc332kmo.1 uc332kmo.1 
ENSMUST00000263147.1 ENSMUSG00000124338 ENSMUST00000263147.1 ENSMUSG00000124338 (from geneSymbol) uc332kmp.1 uc332kmp.1 
ENSMUST00000263150.1 ENSMUSG00000124339 ENSMUST00000263150.1 ENSMUSG00000124339 (from geneSymbol) uc332kms.1 uc332kms.1 
ENSMUST00000263152.1 ENSMUSG00000124340 ENSMUST00000263152.1 ENSMUSG00000124340 (from geneSymbol) uc332kmu.1 uc332kmu.1 
ENSMUST00000263153.1 ENSMUSG00000124341 ENSMUST00000263153.1 ENSMUSG00000124341 (from geneSymbol) uc332kmv.1 uc332kmv.1 
ENSMUST00000263156.1 ENSMUSG00000124342 ENSMUST00000263156.1 ENSMUSG00000124342 (from geneSymbol) uc332kmy.1 uc332kmy.1 
ENSMUST00000263157.1 ENSMUSG00000124343 ENSMUST00000263157.1 ENSMUSG00000124343 (from geneSymbol) uc332kmz.1 uc332kmz.1 
ENSMUST00000263159.1 ENSMUSG00000124344 ENSMUST00000263159.1 ENSMUSG00000124344 (from geneSymbol) uc332knb.1 uc332knb.1 
ENSMUST00000263162.1 ENSMUSG00000124345 ENSMUST00000263162.1 ENSMUSG00000124345 (from geneSymbol) uc332kne.1 uc332kne.1 
ENSMUST00000263163.1 ENSMUSG00000124346 ENSMUST00000263163.1 ENSMUSG00000124346 (from geneSymbol) uc332knf.1 uc332knf.1 
ENSMUST00000263166.1 ENSMUSG00000124347 ENSMUST00000263166.1 ENSMUSG00000124347 (from geneSymbol) uc332kni.1 uc332kni.1 
ENSMUST00000263168.1 ENSMUSG00000124348 ENSMUST00000263168.1 ENSMUSG00000124348 (from geneSymbol) uc332knk.1 uc332knk.1 
ENSMUST00000263172.1 ENSMUSG00000124349 ENSMUST00000263172.1 ENSMUSG00000124349 (from geneSymbol) uc332kno.1 uc332kno.1 
ENSMUST00000263174.1 A930005G22Rik ENSMUST00000263174.1 RIKEN cDNA A930005G22 gene, transcript variant 3 (from RefSeq NR_168295.1) NR_168295 uc332knq.1 uc332knq.1 
ENSMUST00000263177.1 ENSMUSG00000124351 ENSMUST00000263177.1 ENSMUSG00000124351 (from geneSymbol) uc332knt.1 uc332knt.1 
ENSMUST00000263184.1 ENSMUSG00000124352 ENSMUST00000263184.1 ENSMUSG00000124352 (from geneSymbol) uc332koa.1 uc332koa.1 
ENSMUST00000263189.1 ENSMUSG00000124353 ENSMUST00000263189.1 ENSMUSG00000124353 (from geneSymbol) uc332kof.1 uc332kof.1 
ENSMUST00000263190.1 ENSMUSG00000124354 ENSMUST00000263190.1 ENSMUSG00000124354 (from geneSymbol) uc332kog.1 uc332kog.1 
ENSMUST00000263194.1 Gm41597 ENSMUST00000263194.1 Gm41597 (from geneSymbol) uc332kok.1 uc332kok.1 
ENSMUST00000263201.1 ENSMUSG00000124355 ENSMUST00000263201.1 ENSMUSG00000124355 (from geneSymbol) uc332kor.1 uc332kor.1 
ENSMUST00000263202.1 ENSMUSG00000124356 ENSMUST00000263202.1 ENSMUSG00000124356 (from geneSymbol) uc332kos.1 uc332kos.1 
ENSMUST00000263205.1 ENSMUSG00000124357 ENSMUST00000263205.1 ENSMUSG00000124357 (from geneSymbol) uc332kov.1 uc332kov.1 
ENSMUST00000263210.1 ENSMUSG00000124358 ENSMUST00000263210.1 ENSMUSG00000124358 (from geneSymbol) uc332kpa.1 uc332kpa.1 
ENSMUST00000263211.1 ENSMUSG00000124359 ENSMUST00000263211.1 ENSMUSG00000124359 (from geneSymbol) uc332kpb.1 uc332kpb.1 
ENSMUST00000263212.1 ENSMUSG00000124360 ENSMUST00000263212.1 ENSMUSG00000124360 (from geneSymbol) uc332kpc.1 uc332kpc.1 
ENSMUST00000263219.1 ENSMUSG00000124361 ENSMUST00000263219.1 ENSMUSG00000124361 (from geneSymbol) AK083219 uc332kpj.1 uc332kpj.1 
ENSMUST00000263225.1 ENSMUSG00000124362 ENSMUST00000263225.1 ENSMUSG00000124362 (from geneSymbol) uc332kpp.1 uc332kpp.1 
ENSMUST00000263226.1 ENSMUSG00000124363 ENSMUST00000263226.1 ENSMUSG00000124363 (from geneSymbol) uc332kpq.1 uc332kpq.1 
ENSMUST00000263232.1 ENSMUSG00000124364 ENSMUST00000263232.1 ENSMUSG00000124364 (from geneSymbol) uc332kpw.1 uc332kpw.1 
ENSMUST00000263234.1 Gm12536 ENSMUST00000263234.1 Gm12536 (from geneSymbol) uc332kpy.1 uc332kpy.1 
ENSMUST00000263239.1 ENSMUSG00000124365 ENSMUST00000263239.1 ENSMUSG00000124365 (from geneSymbol) uc332kqd.1 uc332kqd.1 
ENSMUST00000263241.1 ENSMUSG00000124367 ENSMUST00000263241.1 ENSMUSG00000124367 (from geneSymbol) uc332kqe.1 uc332kqe.1 
ENSMUST00000263242.1 Gm14152 ENSMUST00000263242.1 Gm14152 (from geneSymbol) AK006486 uc332kqf.1 uc332kqf.1 
ENSMUST00000263316.1 1700095J12Rik ENSMUST00000263316.1 1700095J12Rik (from geneSymbol) AK007084 uc332ktb.1 uc332ktb.1 
ENSMUST00000263328.1 ENSMUSG00000124368 ENSMUST00000263328.1 ENSMUSG00000124368 (from geneSymbol) uc332ktn.1 uc332ktn.1 
ENSMUST00000263329.1 1700094M23Rik ENSMUST00000263329.1 1700094M23Rik (from geneSymbol) AK015610 uc332kto.1 uc332kto.1 
ENSMUST00000263353.1 Gm34732 ENSMUST00000263353.1 Gm34732 (from geneSymbol) uc332kum.1 uc332kum.1 
ENSMUST00000263376.1 ENSMUSG00000124369 ENSMUST00000263376.1 ENSMUSG00000124369 (from geneSymbol) uc332kvj.1 uc332kvj.1 
ENSMUST00000263381.1 ENSMUSG00000124370 ENSMUST00000263381.1 ENSMUSG00000124370 (from geneSymbol) uc332kvo.1 uc332kvo.1 
ENSMUST00000263382.1 ENSMUSG00000124371 ENSMUST00000263382.1 ENSMUSG00000124371 (from geneSymbol) uc332kvp.1 uc332kvp.1 
ENSMUST00000263384.1 ENSMUSG00000124372 ENSMUST00000263384.1 ENSMUSG00000124372 (from geneSymbol) uc332kvr.1 uc332kvr.1 
ENSMUST00000263385.1 ENSMUSG00000124373 ENSMUST00000263385.1 ENSMUSG00000124373 (from geneSymbol) uc332kvs.1 uc332kvs.1 
ENSMUST00000263386.1 Gm16180 ENSMUST00000263386.1 Gm16180 (from geneSymbol) uc332kvt.1 uc332kvt.1 
ENSMUST00000263387.1 Gm14968 ENSMUST00000263387.1 Gm14968 (from geneSymbol) uc332kvu.1 uc332kvu.1 
ENSMUST00000263390.1 ENSMUSG00000124374 ENSMUST00000263390.1 ENSMUSG00000124374 (from geneSymbol) uc332kvx.1 uc332kvx.1 
ENSMUST00000263393.1 ENSMUSG00000124375 ENSMUST00000263393.1 ENSMUSG00000124375 (from geneSymbol) uc332kwa.1 uc332kwa.1 
ENSMUST00000263396.1 ENSMUSG00000124376 ENSMUST00000263396.1 ENSMUSG00000124376 (from geneSymbol) uc332kwd.1 uc332kwd.1 
ENSMUST00000263403.1 ENSMUSG00000124377 ENSMUST00000263403.1 ENSMUSG00000124377 (from geneSymbol) uc332kwk.1 uc332kwk.1 
ENSMUST00000263404.1 ENSMUSG00000124378 ENSMUST00000263404.1 ENSMUSG00000124378 (from geneSymbol) uc332kwl.1 uc332kwl.1 
ENSMUST00000263412.1 ENSMUSG00000124379 ENSMUST00000263412.1 ENSMUSG00000124379 (from geneSymbol) uc332kwt.1 uc332kwt.1 
ENSMUST00000263420.1 Gm48236 ENSMUST00000263420.1 Gm48236 (from geneSymbol) uc332kxb.1 uc332kxb.1 
ENSMUST00000263431.1 ENSMUSG00000124380 ENSMUST00000263431.1 ENSMUSG00000124380 (from geneSymbol) uc332kxm.1 uc332kxm.1 
ENSMUST00000263432.1 Gm47177 ENSMUST00000263432.1 Gm47177 (from geneSymbol) uc332kxn.1 uc332kxn.1 
ENSMUST00000263436.1 Gm17830 ENSMUST00000263436.1 Gm17830 (from geneSymbol) AK135726 uc332kxr.1 uc332kxr.1 
ENSMUST00000263454.1 Gm29642 ENSMUST00000263454.1 predicted gene 29642, transcript variant 1 (from RefSeq NR_169024.1) NR_169024 uc332kyj.1 uc332kyj.1 
ENSMUST00000263494.1 4930401G09Rik ENSMUST00000263494.1 4930401G09Rik (from geneSymbol) AK015035 uc332kzx.1 uc332kzx.1 
ENSMUST00000263497.1 ENSMUSG00000124381 ENSMUST00000263497.1 predicted gene, 16907 (from RefSeq NR_045794.1) NR_045794 uc332laa.1 uc332laa.1 
ENSMUST00000263499.1 ENSMUSG00000124382 ENSMUST00000263499.1 ENSMUSG00000124382 (from geneSymbol) uc332lac.1 uc332lac.1 
ENSMUST00000263500.1 ENSMUSG00000124383 ENSMUST00000263500.1 ENSMUSG00000124383 (from geneSymbol) uc332lad.1 uc332lad.1 
ENSMUST00000263502.1 ENSMUSG00000124384 ENSMUST00000263502.1 ENSMUSG00000124384 (from geneSymbol) uc332laf.1 uc332laf.1 
ENSMUST00000263503.1 4930567K20Rik ENSMUST00000263503.1 4930567K20Rik (from geneSymbol) AK006633 uc332lag.1 uc332lag.1 
ENSMUST00000263514.1 ENSMUSG00000124385 ENSMUST00000263514.1 ENSMUSG00000124385 (from geneSymbol) uc332lar.1 uc332lar.1 
ENSMUST00000263515.1 ENSMUSG00000124386 ENSMUST00000263515.1 ENSMUSG00000124386 (from geneSymbol) uc332las.1 uc332las.1 
ENSMUST00000263516.1 ENSMUSG00000124387 ENSMUST00000263516.1 ENSMUSG00000124387 (from geneSymbol) uc332lat.1 uc332lat.1 
ENSMUST00000263519.1 ENSMUSG00000124388 ENSMUST00000263519.1 ENSMUSG00000124388 (from geneSymbol) uc332law.1 uc332law.1 
ENSMUST00000263525.1 AY702103 ENSMUST00000263525.1 AY702103 (from geneSymbol) AK133160 uc332lbc.1 uc332lbc.1 
ENSMUST00000263527.1 ENSMUSG00000124389 ENSMUST00000263527.1 ENSMUSG00000124389 (from geneSymbol) uc332lbe.1 uc332lbe.1 
ENSMUST00000263529.1 ENSMUSG00000124390 ENSMUST00000263529.1 ENSMUSG00000124390 (from geneSymbol) uc332lbg.1 uc332lbg.1 
ENSMUST00000263530.1 ENSMUSG00000124391 ENSMUST00000263530.1 ENSMUSG00000124391 (from geneSymbol) uc332lbh.1 uc332lbh.1 
ENSMUST00000263531.1 ENSMUSG00000124392 ENSMUST00000263531.1 ENSMUSG00000124392 (from geneSymbol) uc332lbi.1 uc332lbi.1 
ENSMUST00000263532.1 ENSMUSG00000124393 ENSMUST00000263532.1 ENSMUSG00000124393 (from geneSymbol) uc332lbj.1 uc332lbj.1 
ENSMUST00000263534.1 ENSMUSG00000124395 ENSMUST00000263534.1 ENSMUSG00000124395 (from geneSymbol) uc332lbk.1 uc332lbk.1 
ENSMUST00000263536.1 Gm17644 ENSMUST00000263536.1 Gm17644 (from geneSymbol) AK029971 uc332lbm.1 uc332lbm.1 
ENSMUST00000263547.1 ENSMUSG00000124396 ENSMUST00000263547.1 ENSMUSG00000124396 (from geneSymbol) uc332lbx.1 uc332lbx.1 
ENSMUST00000263549.1 ENSMUSG00000124397 ENSMUST00000263549.1 ENSMUSG00000124397 (from geneSymbol) uc332lbz.1 uc332lbz.1 
ENSMUST00000263550.1 ENSMUSG00000124398 ENSMUST00000263550.1 ENSMUSG00000124398 (from geneSymbol) uc332lca.1 uc332lca.1 
ENSMUST00000263554.1 ENSMUSG00000124399 ENSMUST00000263554.1 ENSMUSG00000124399 (from geneSymbol) uc332lce.1 uc332lce.1 
ENSMUST00000263555.1 ENSMUSG00000124400 ENSMUST00000263555.1 ENSMUSG00000124400 (from geneSymbol) uc332lcf.1 uc332lcf.1 
ENSMUST00000263556.1 4933439J24Rik ENSMUST00000263556.1 4933439J24Rik (from geneSymbol) uc332lcg.1 uc332lcg.1 
ENSMUST00000263559.1 ENSMUSG00000124401 ENSMUST00000263559.1 ENSMUSG00000124401 (from geneSymbol) uc332lcj.1 uc332lcj.1 
ENSMUST00000263562.1 ENSMUSG00000124402 ENSMUST00000263562.1 ENSMUSG00000124402 (from geneSymbol) uc332lcm.1 uc332lcm.1 
ENSMUST00000263563.1 ENSMUSG00000124403 ENSMUST00000263563.1 ENSMUSG00000124403 (from geneSymbol) uc332lcn.1 uc332lcn.1 
ENSMUST00000263571.1 Gm20714 ENSMUST00000263571.1 Gm20714 (from geneSymbol) AK076963 uc332lcv.1 uc332lcv.1 
ENSMUST00000263592.1 ENSMUSG00000124404 ENSMUST00000263592.1 ENSMUSG00000124404 (from geneSymbol) uc332ldq.1 uc332ldq.1 
ENSMUST00000263593.1 ENSMUSG00000124405 ENSMUST00000263593.1 ENSMUSG00000124405 (from geneSymbol) uc332ldr.1 uc332ldr.1 
ENSMUST00000263597.1 ENSMUSG00000124406 ENSMUST00000263597.1 ENSMUSG00000124406 (from geneSymbol) uc332ldv.1 uc332ldv.1 
ENSMUST00000263602.1 ENSMUSG00000124407 ENSMUST00000263602.1 ENSMUSG00000124407 (from geneSymbol) uc332lea.1 uc332lea.1 
ENSMUST00000263607.1 ENSMUSG00000124408 ENSMUST00000263607.1 ENSMUSG00000124408 (from geneSymbol) uc332lef.1 uc332lef.1 
ENSMUST00000263608.1 ENSMUSG00000124409 ENSMUST00000263608.1 RIKEN cDNA 4930528A17 gene (from RefSeq NR_028384.1) NR_028384 uc332leg.1 uc332leg.1 
ENSMUST00000263610.1 ENSMUSG00000124410 ENSMUST00000263610.1 ENSMUSG00000124410 (from geneSymbol) uc332lei.1 uc332lei.1 
ENSMUST00000263616.1 ENSMUSG00000124411 ENSMUST00000263616.1 ENSMUSG00000124411 (from geneSymbol) uc332leo.1 uc332leo.1 
ENSMUST00000263617.1 ENSMUSG00000124412 ENSMUST00000263617.1 ENSMUSG00000124412 (from geneSymbol) uc332lep.1 uc332lep.1 
ENSMUST00000263618.1 ENSMUSG00000124413 ENSMUST00000263618.1 ENSMUSG00000124413 (from geneSymbol) uc332leq.1 uc332leq.1 
ENSMUST00000263625.1 Gm47662 ENSMUST00000263625.1 Gm47662 (from geneSymbol) AK156530 uc332lex.1 uc332lex.1 
ENSMUST00000263628.1 ENSMUSG00000124414 ENSMUST00000263628.1 ENSMUSG00000124414 (from geneSymbol) uc332lfa.1 uc332lfa.1 
ENSMUST00000263629.1 ENSMUSG00000124415 ENSMUST00000263629.1 ENSMUSG00000124415 (from geneSymbol) uc332lfb.1 uc332lfb.1 
ENSMUST00000263630.1 Gm20751 ENSMUST00000263630.1 Gm20751 (from geneSymbol) AK038993 uc332lfc.1 uc332lfc.1 
ENSMUST00000263646.1 ENSMUSG00000124416 ENSMUST00000263646.1 ENSMUSG00000124416 (from geneSymbol) uc332lfs.1 uc332lfs.1 
ENSMUST00000263650.1 ENSMUSG00000124417 ENSMUST00000263650.1 ENSMUSG00000124417 (from geneSymbol) uc332lfw.1 uc332lfw.1 
ENSMUST00000263652.1 ENSMUSG00000124418 ENSMUST00000263652.1 ENSMUSG00000124418 (from geneSymbol) uc332lfy.1 uc332lfy.1 
ENSMUST00000263656.1 ENSMUSG00000124419 ENSMUST00000263656.1 ENSMUSG00000124419 (from geneSymbol) uc332lgc.1 uc332lgc.1 
ENSMUST00000263660.1 ENSMUSG00000124420 ENSMUST00000263660.1 ENSMUSG00000124420 (from geneSymbol) uc332lgg.1 uc332lgg.1 
ENSMUST00000263661.1 ENSMUSG00000124421 ENSMUST00000263661.1 ENSMUSG00000124421 (from geneSymbol) uc332lgh.1 uc332lgh.1 
ENSMUST00000263664.1 ENSMUSG00000124422 ENSMUST00000263664.1 ENSMUSG00000124422 (from geneSymbol) uc332lgk.1 uc332lgk.1 
ENSMUST00000263671.1 ENSMUSG00000124423 ENSMUST00000263671.1 ENSMUSG00000124423 (from geneSymbol) uc332lgr.1 uc332lgr.1 
ENSMUST00000263672.1 ENSMUSG00000124424 ENSMUST00000263672.1 ENSMUSG00000124424 (from geneSymbol) uc332lgs.1 uc332lgs.1 
ENSMUST00000263675.1 ENSMUSG00000124425 ENSMUST00000263675.1 ENSMUSG00000124425 (from geneSymbol) uc332lgv.1 uc332lgv.1 
ENSMUST00000263676.1 ENSMUSG00000124426 ENSMUST00000263676.1 ENSMUSG00000124426 (from geneSymbol) uc332lgw.1 uc332lgw.1 
ENSMUST00000263680.1 ENSMUSG00000124428 ENSMUST00000263680.1 ENSMUSG00000124428 (from geneSymbol) uc332lgx.1 uc332lgx.1 
ENSMUST00000263681.1 ENSMUSG00000124429 ENSMUST00000263681.1 ENSMUSG00000124429 (from geneSymbol) uc332lgy.1 uc332lgy.1 
ENSMUST00000263683.1 ENSMUSG00000124430 ENSMUST00000263683.1 ENSMUSG00000124430 (from geneSymbol) uc332lha.1 uc332lha.1 
ENSMUST00000263685.1 ENSMUSG00000124431 ENSMUST00000263685.1 ENSMUSG00000124431 (from geneSymbol) uc332lhc.1 uc332lhc.1 
ENSMUST00000263686.1 ENSMUSG00000124432 ENSMUST00000263686.1 ENSMUSG00000124432 (from geneSymbol) uc332lhd.1 uc332lhd.1 
ENSMUST00000263689.1 ENSMUSG00000124433 ENSMUST00000263689.1 ENSMUSG00000124433 (from geneSymbol) uc332lhg.1 uc332lhg.1 
ENSMUST00000263696.1 ENSMUSG00000124434 ENSMUST00000263696.1 ENSMUSG00000124434 (from geneSymbol) uc332lhn.1 uc332lhn.1 
ENSMUST00000263705.1 ENSMUSG00000124435 ENSMUST00000263705.1 ENSMUSG00000124435 (from geneSymbol) uc332lhw.1 uc332lhw.1 
ENSMUST00000263706.1 ENSMUSG00000124436 ENSMUST00000263706.1 ENSMUSG00000124436 (from geneSymbol) uc332lhx.1 uc332lhx.1 
ENSMUST00000263712.1 ENSMUSG00000124437 ENSMUST00000263712.1 ENSMUSG00000124437 (from geneSymbol) uc332lid.1 uc332lid.1 
ENSMUST00000263713.1 ENSMUSG00000124438 ENSMUST00000263713.1 ENSMUSG00000124438 (from geneSymbol) uc332lie.1 uc332lie.1 
ENSMUST00000263714.1 ENSMUSG00000124439 ENSMUST00000263714.1 ENSMUSG00000124439 (from geneSymbol) uc332lif.1 uc332lif.1 
ENSMUST00000263715.1 Gm29663 ENSMUST00000263715.1 Gm29663 (from geneSymbol) uc332lig.1 uc332lig.1 
ENSMUST00000263717.1 ENSMUSG00000124440 ENSMUST00000263717.1 ENSMUSG00000124440 (from geneSymbol) uc332lii.1 uc332lii.1 
ENSMUST00000263724.1 ENSMUSG00000124441 ENSMUST00000263724.1 ENSMUSG00000124441 (from geneSymbol) uc332lip.1 uc332lip.1 
ENSMUST00000263729.1 ENSMUSG00000124442 ENSMUST00000263729.1 ENSMUSG00000124442 (from geneSymbol) uc332liu.1 uc332liu.1 
ENSMUST00000263731.1 Gm26618 ENSMUST00000263731.1 Gm26618 (from geneSymbol) uc332liw.1 uc332liw.1 
ENSMUST00000263756.1 ENSMUSG00000124443 ENSMUST00000263756.1 ENSMUSG00000124443 (from geneSymbol) uc332ljs.1 uc332ljs.1 
ENSMUST00000263766.1 5430437J10Rik ENSMUST00000263766.1 5430437J10Rik (from geneSymbol) BC023070 uc332lkc.1 uc332lkc.1 
ENSMUST00000263784.1 ENSMUSG00000124444 ENSMUST00000263784.1 ENSMUSG00000124444 (from geneSymbol) uc332lku.1 uc332lku.1 
ENSMUST00000263786.1 ENSMUSG00000124445 ENSMUST00000263786.1 ENSMUSG00000124445 (from geneSymbol) uc332lkw.1 uc332lkw.1 
ENSMUST00000263787.1 ENSMUSG00000124446 ENSMUST00000263787.1 ENSMUSG00000124446 (from geneSymbol) uc332lkx.1 uc332lkx.1 
ENSMUST00000263788.1 ENSMUSG00000124447 ENSMUST00000263788.1 ENSMUSG00000124447 (from geneSymbol) uc332lky.1 uc332lky.1 
ENSMUST00000263793.1 ENSMUSG00000124448 ENSMUST00000263793.1 ENSMUSG00000124448 (from geneSymbol) uc332lld.1 uc332lld.1 
ENSMUST00000263795.1 ENSMUSG00000124449 ENSMUST00000263795.1 ENSMUSG00000124449 (from geneSymbol) AK046160 uc332llf.1 uc332llf.1 
ENSMUST00000263797.1 ENSMUSG00000124450 ENSMUST00000263797.1 ENSMUSG00000124450 (from geneSymbol) uc332llh.1 uc332llh.1 
ENSMUST00000263819.1 ENSMUSG00000124451 ENSMUST00000263819.1 ENSMUSG00000124451 (from geneSymbol) uc332lmd.1 uc332lmd.1 
ENSMUST00000263820.1 ENSMUSG00000124452 ENSMUST00000263820.1 ENSMUSG00000124452 (from geneSymbol) uc332lme.1 uc332lme.1 
ENSMUST00000263821.1 ENSMUSG00000124453 ENSMUST00000263821.1 ENSMUSG00000124453 (from geneSymbol) uc332lmf.1 uc332lmf.1 
ENSMUST00000263823.1 ENSMUSG00000124454 ENSMUST00000263823.1 ENSMUSG00000124454 (from geneSymbol) uc332lmh.1 uc332lmh.1 
ENSMUST00000263827.1 ENSMUSG00000124455 ENSMUST00000263827.1 ENSMUSG00000124455 (from geneSymbol) uc332lml.1 uc332lml.1 
ENSMUST00000263829.1 ENSMUSG00000124457 ENSMUST00000263829.1 ENSMUSG00000124457 (from geneSymbol) uc332lmm.1 uc332lmm.1 
ENSMUST00000263833.1 ENSMUSG00000124459 ENSMUST00000263833.1 ENSMUSG00000124459 (from geneSymbol) uc332lmp.1 uc332lmp.1 
ENSMUST00000263835.1 ENSMUSG00000124461 ENSMUST00000263835.1 ENSMUSG00000124461 (from geneSymbol) uc332lmq.1 uc332lmq.1 
ENSMUST00000263836.1 ENSMUSG00000124462 ENSMUST00000263836.1 ENSMUSG00000124462 (from geneSymbol) uc332lmr.1 uc332lmr.1 
ENSMUST00000263837.1 ENSMUSG00000124463 ENSMUST00000263837.1 ENSMUSG00000124463 (from geneSymbol) uc332lms.1 uc332lms.1 
ENSMUST00000263838.1 Gm57320 ENSMUST00000263838.1 Gm57320 (from geneSymbol) uc332lmt.1 uc332lmt.1 
ENSMUST00000263839.1 ENSMUSG00000124464 ENSMUST00000263839.1 ENSMUSG00000124464 (from geneSymbol) uc332lmu.1 uc332lmu.1 
ENSMUST00000263841.1 ENSMUSG00000124465 ENSMUST00000263841.1 ENSMUSG00000124465 (from geneSymbol) uc332lmw.1 uc332lmw.1 
ENSMUST00000263850.1 ENSMUSG00000124466 ENSMUST00000263850.1 ENSMUSG00000124466 (from geneSymbol) uc332lnf.1 uc332lnf.1 
ENSMUST00000263851.1 ENSMUSG00000124467 ENSMUST00000263851.1 ENSMUSG00000124467 (from geneSymbol) uc332lng.1 uc332lng.1 
ENSMUST00000263852.1 ENSMUSG00000124468 ENSMUST00000263852.1 ENSMUSG00000124468 (from geneSymbol) uc332lnh.1 uc332lnh.1 
ENSMUST00000263855.1 ENSMUSG00000124469 ENSMUST00000263855.1 ENSMUSG00000124469 (from geneSymbol) uc332lnk.1 uc332lnk.1 
ENSMUST00000263864.1 ENSMUSG00000124470 ENSMUST00000263864.1 ENSMUSG00000124470 (from geneSymbol) uc332lnt.1 uc332lnt.1 
ENSMUST00000263866.1 ENSMUSG00000124471 ENSMUST00000263866.1 ENSMUSG00000124471 (from geneSymbol) uc332lnv.1 uc332lnv.1 
ENSMUST00000263870.1 ENSMUSG00000124472 ENSMUST00000263870.1 ENSMUSG00000124472 (from geneSymbol) uc332lnz.1 uc332lnz.1 
ENSMUST00000263871.1 ENSMUSG00000124473 ENSMUST00000263871.1 ENSMUSG00000124473 (from geneSymbol) uc332loa.1 uc332loa.1 
ENSMUST00000263877.1 ENSMUSG00000124474 ENSMUST00000263877.1 ENSMUSG00000124474 (from geneSymbol) uc332log.1 uc332log.1 
ENSMUST00000263878.1 ENSMUSG00000124475 ENSMUST00000263878.1 ENSMUSG00000124475 (from geneSymbol) uc332loh.1 uc332loh.1 
ENSMUST00000263879.1 ENSMUSG00000124476 ENSMUST00000263879.1 ENSMUSG00000124476 (from geneSymbol) uc332loi.1 uc332loi.1 
ENSMUST00000263882.1 ENSMUSG00000124477 ENSMUST00000263882.1 ENSMUSG00000124477 (from geneSymbol) uc332lol.1 uc332lol.1 
ENSMUST00000263888.1 1700034G24Rik ENSMUST00000263888.1 1700034G24Rik (from geneSymbol) AK006593 uc332lor.1 uc332lor.1 
ENSMUST00000263894.1 Gm32816 ENSMUST00000263894.1 Gm32816 (from geneSymbol) uc332lox.1 uc332lox.1 
ENSMUST00000263902.1 ENSMUSG00000124478 ENSMUST00000263902.1 ENSMUSG00000124478 (from geneSymbol) uc332lpf.1 uc332lpf.1 
ENSMUST00000263903.1 ENSMUSG00000124479 ENSMUST00000263903.1 ENSMUSG00000124479 (from geneSymbol) uc332lpg.1 uc332lpg.1 
ENSMUST00000263905.1 Gm35035 ENSMUST00000263905.1 Gm35035 (from geneSymbol) uc332lpi.1 uc332lpi.1 
ENSMUST00000263910.1 ENSMUSG00000124480 ENSMUST00000263910.1 ENSMUSG00000124480 (from geneSymbol) uc332lpn.1 uc332lpn.1 
ENSMUST00000263913.1 ENSMUSG00000124481 ENSMUST00000263913.1 ENSMUSG00000124481 (from geneSymbol) uc332lpq.1 uc332lpq.1 
ENSMUST00000263914.1 ENSMUSG00000124482 ENSMUST00000263914.1 ENSMUSG00000124482 (from geneSymbol) uc332lpr.1 uc332lpr.1 
ENSMUST00000263916.1 ENSMUSG00000124483 ENSMUST00000263916.1 ENSMUSG00000124483 (from geneSymbol) uc332lpt.1 uc332lpt.1 
ENSMUST00000263917.1 ENSMUSG00000124484 ENSMUST00000263917.1 ENSMUSG00000124484 (from geneSymbol) uc332lpu.1 uc332lpu.1 
ENSMUST00000263919.1 ENSMUSG00000124486 ENSMUST00000263919.1 ENSMUSG00000124486 (from geneSymbol) uc332lpv.1 uc332lpv.1 
ENSMUST00000263920.1 ENSMUSG00000124487 ENSMUST00000263920.1 ENSMUSG00000124487 (from geneSymbol) uc332lpw.1 uc332lpw.1 
ENSMUST00000263922.1 ENSMUSG00000124488 ENSMUST00000263922.1 ENSMUSG00000124488 (from geneSymbol) uc332lpy.1 uc332lpy.1 
ENSMUST00000263923.1 Otx2os1 ENSMUST00000263923.1 Otx2os1 (from geneSymbol) AK042665 uc332lpz.1 uc332lpz.1 
ENSMUST00000263969.1 ENSMUSG00000124489 ENSMUST00000263969.1 ENSMUSG00000124489 (from geneSymbol) uc332lrs.1 uc332lrs.1 
ENSMUST00000263971.1 ENSMUSG00000124490 ENSMUST00000263971.1 ENSMUSG00000124490 (from geneSymbol) uc332lru.1 uc332lru.1 
ENSMUST00000263974.1 ENSMUSG00000124491 ENSMUST00000263974.1 ENSMUSG00000124491 (from geneSymbol) uc332lrx.1 uc332lrx.1 
ENSMUST00000263977.1 ENSMUSG00000124492 ENSMUST00000263977.1 ENSMUSG00000124492 (from geneSymbol) uc332lsa.1 uc332lsa.1 
ENSMUST00000263978.1 ENSMUSG00000124493 ENSMUST00000263978.1 ENSMUSG00000124493 (from geneSymbol) AK016703 uc332lsb.1 uc332lsb.1 
ENSMUST00000263979.1 ENSMUSG00000124494 ENSMUST00000263979.1 ENSMUSG00000124494 (from geneSymbol) uc332lsc.1 uc332lsc.1 
ENSMUST00000263980.1 ENSMUSG00000124495 ENSMUST00000263980.1 ENSMUSG00000124495 (from geneSymbol) uc332lsd.1 uc332lsd.1 
ENSMUST00000263981.1 ENSMUSG00000124496 ENSMUST00000263981.1 ENSMUSG00000124496 (from geneSymbol) uc332lse.1 uc332lse.1 
ENSMUST00000263982.1 ENSMUSG00000124497 ENSMUST00000263982.1 ENSMUSG00000124497 (from geneSymbol) uc332lsf.1 uc332lsf.1 
ENSMUST00000263985.1 ENSMUSG00000124498 ENSMUST00000263985.1 ENSMUSG00000124498 (from geneSymbol) uc332lsi.1 uc332lsi.1 
ENSMUST00000264015.1 Gm29824 ENSMUST00000264015.1 Gm29824 (from geneSymbol) uc332ltm.1 uc332ltm.1 
ENSMUST00000264027.1 ENSMUSG00000124499 ENSMUST00000264027.1 ENSMUSG00000124499 (from geneSymbol) uc332lty.1 uc332lty.1 
ENSMUST00000264030.1 ENSMUSG00000124500 ENSMUST00000264030.1 ENSMUSG00000124500 (from geneSymbol) uc332lub.1 uc332lub.1 
ENSMUST00000264033.1 ENSMUSG00000124501 ENSMUST00000264033.1 ENSMUSG00000124501 (from geneSymbol) uc332lue.1 uc332lue.1 
ENSMUST00000264034.1 ENSMUSG00000124502 ENSMUST00000264034.1 ENSMUSG00000124502 (from geneSymbol) uc332luf.1 uc332luf.1 
ENSMUST00000264036.1 Cypt15-ps ENSMUST00000264036.1 Cypt15-ps (from geneSymbol) BC100466 uc332luh.1 uc332luh.1 
ENSMUST00000264037.1 ENSMUSG00000124504 ENSMUST00000264037.1 ENSMUSG00000124504 (from geneSymbol) uc332lui.1 uc332lui.1 
ENSMUST00000264039.1 ENSMUSG00000124503 ENSMUST00000264039.1 ENSMUSG00000124503 (from geneSymbol) uc332luk.1 uc332luk.1 
ENSMUST00000264045.1 ENSMUSG00000124505 ENSMUST00000264045.1 ENSMUSG00000124505 (from geneSymbol) uc332luq.1 uc332luq.1 
ENSMUST00000264046.1 ENSMUSG00000124506 ENSMUST00000264046.1 ENSMUSG00000124506 (from geneSymbol) uc332lur.1 uc332lur.1 
ENSMUST00000264048.1 ENSMUSG00000124507 ENSMUST00000264048.1 ENSMUSG00000124507 (from geneSymbol) uc332lus.1 uc332lus.1 
ENSMUST00000264052.1 ENSMUSG00000124508 ENSMUST00000264052.1 ENSMUSG00000124508 (from geneSymbol) uc332luv.1 uc332luv.1 
ENSMUST00000264057.1 ENSMUSG00000124509 ENSMUST00000264057.1 ENSMUSG00000124509 (from geneSymbol) uc332lva.1 uc332lva.1 
ENSMUST00000264058.1 9230114K14Rik ENSMUST00000264058.1 9230114K14Rik (from geneSymbol) AK079034 uc332lvb.1 uc332lvb.1 
ENSMUST00000264080.1 ENSMUSG00000124510 ENSMUST00000264080.1 ENSMUSG00000124510 (from geneSymbol) uc332lvx.1 uc332lvx.1 
ENSMUST00000264083.1 ENSMUSG00000124511 ENSMUST00000264083.1 ENSMUSG00000124511 (from geneSymbol) AF288381 uc332lwa.1 uc332lwa.1 
ENSMUST00000264086.1 4930527G23Rik ENSMUST00000264086.1 4930527G23Rik (from geneSymbol) AK019704 uc332lwd.1 uc332lwd.1 
ENSMUST00000264105.1 ENSMUSG00000124512 ENSMUST00000264105.1 ENSMUSG00000124512 (from geneSymbol) uc332lww.1 uc332lww.1 
ENSMUST00000264109.1 BC048644 ENSMUST00000264109.1 BC048644 (from geneSymbol) AK133128 uc332lxa.1 uc332lxa.1 
ENSMUST00000264112.1 ENSMUSG00000124513 ENSMUST00000264112.1 ENSMUSG00000124513 (from geneSymbol) uc332lxd.1 uc332lxd.1 
ENSMUST00000264113.1 ENSMUSG00000124514 ENSMUST00000264113.1 ENSMUSG00000124514 (from geneSymbol) AK006721 uc332lxe.1 uc332lxe.1 
ENSMUST00000264157.1 ENSMUSG00000124515 ENSMUST00000264157.1 ENSMUSG00000124515 (from geneSymbol) uc332lyw.1 uc332lyw.1 
ENSMUST00000264186.1 Lncbate1 ENSMUST00000264186.1 Lncbate1 (from geneSymbol) AK080070 uc332lzz.1 uc332lzz.1 
ENSMUST00000264197.1 ENSMUSG00000124516 ENSMUST00000264197.1 ENSMUSG00000124516 (from geneSymbol) uc332mak.1 uc332mak.1 
ENSMUST00000264203.1 ENSMUSG00000124517 ENSMUST00000264203.1 ENSMUSG00000124517 (from geneSymbol) uc332maq.1 uc332maq.1 
ENSMUST00000264206.1 ENSMUSG00000124518 ENSMUST00000264206.1 ENSMUSG00000124518 (from geneSymbol) uc332mat.1 uc332mat.1 
ENSMUST00000264207.1 ENSMUSG00000124519 ENSMUST00000264207.1 ENSMUSG00000124519 (from geneSymbol) uc332mau.1 uc332mau.1 
ENSMUST00000264212.1 ENSMUSG00000124520 ENSMUST00000264212.1 ENSMUSG00000124520 (from geneSymbol) uc332may.1 uc332may.1 
ENSMUST00000264214.1 ENSMUSG00000124521 ENSMUST00000264214.1 ENSMUSG00000124521 (from geneSymbol) uc332mba.1 uc332mba.1 
ENSMUST00000264216.1 ENSMUSG00000124522 ENSMUST00000264216.1 ENSMUSG00000124522 (from geneSymbol) uc332mbc.1 uc332mbc.1 
ENSMUST00000264217.1 ENSMUSG00000124523 ENSMUST00000264217.1 ENSMUSG00000124523 (from geneSymbol) uc332mbd.1 uc332mbd.1 
ENSMUST00000264218.1 ENSMUSG00000124524 ENSMUST00000264218.1 ENSMUSG00000124524 (from geneSymbol) uc332mbe.1 uc332mbe.1 
ENSMUST00000264222.1 ENSMUSG00000124525 ENSMUST00000264222.1 ENSMUSG00000124525 (from geneSymbol) uc332mbi.1 uc332mbi.1 
ENSMUST00000264223.1 ENSMUSG00000124526 ENSMUST00000264223.1 ENSMUSG00000124526 (from geneSymbol) uc332mbj.1 uc332mbj.1 
ENSMUST00000264227.1 ENSMUSG00000124527 ENSMUST00000264227.1 ENSMUSG00000124527 (from geneSymbol) uc332mbn.1 uc332mbn.1 
ENSMUST00000264229.1 ENSMUSG00000124528 ENSMUST00000264229.1 ENSMUSG00000124528 (from geneSymbol) uc332mbp.1 uc332mbp.1 
ENSMUST00000264230.1 AA543186 ENSMUST00000264230.1 expressed sequence AA543186 (from RefSeq NR_027448.1) NR_027448 uc332mbq.1 uc332mbq.1 
ENSMUST00000264232.1 Gm11525 ENSMUST00000264232.1 Gm11525 (from geneSymbol) AK080724 uc332mbs.1 uc332mbs.1 
ENSMUST00000264237.1 ENSMUSG00000124530 ENSMUST00000264237.1 ENSMUSG00000124530 (from geneSymbol) uc332mbx.1 uc332mbx.1 
ENSMUST00000264238.1 ENSMUSG00000124531 ENSMUST00000264238.1 ENSMUSG00000124531 (from geneSymbol) uc332mby.1 uc332mby.1 
ENSMUST00000264243.1 Gm534 ENSMUST00000264243.1 Gm534 (from geneSymbol) uc332mcd.1 uc332mcd.1 
ENSMUST00000264252.1 Gm57259 ENSMUST00000264252.1 Gm57259 (from geneSymbol) uc332mcm.1 uc332mcm.1 
ENSMUST00000264292.1 Gm26901 ENSMUST00000264292.1 Gm26901 (from geneSymbol) AK142999 uc332mea.1 uc332mea.1 
ENSMUST00000264326.1 ENSMUSG00000124532 ENSMUST00000264326.1 ENSMUSG00000124532 (from geneSymbol) uc332mfi.1 uc332mfi.1 
ENSMUST00000264328.1 ENSMUSG00000124533 ENSMUST00000264328.1 ENSMUSG00000124533 (from geneSymbol) uc332mfk.1 uc332mfk.1 
ENSMUST00000264331.1 ENSMUSG00000124534 ENSMUST00000264331.1 ENSMUSG00000124534 (from geneSymbol) uc332mfn.1 uc332mfn.1 
ENSMUST00000264333.1 ENSMUSG00000124536 ENSMUST00000264333.1 ENSMUSG00000124536 (from geneSymbol) uc332mfo.1 uc332mfo.1 
ENSMUST00000264334.1 ENSMUSG00000124537 ENSMUST00000264334.1 ENSMUSG00000124537 (from geneSymbol) uc332mfp.1 uc332mfp.1 
ENSMUST00000264336.1 ENSMUSG00000124538 ENSMUST00000264336.1 ENSMUSG00000124538 (from geneSymbol) uc332mfr.1 uc332mfr.1 
ENSMUST00000264342.1 ENSMUSG00000124539 ENSMUST00000264342.1 ENSMUSG00000124539 (from geneSymbol) uc332mfx.1 uc332mfx.1 
ENSMUST00000264346.1 Gm27211 ENSMUST00000264346.1 Gm27211 (from geneSymbol) uc332mgb.1 uc332mgb.1 
ENSMUST00000264361.1 ENSMUSG00000124540 ENSMUST00000264361.1 ENSMUSG00000124540 (from geneSymbol) uc332mgq.1 uc332mgq.1 
ENSMUST00000264411.1 ENSMUSG00000124541 ENSMUST00000264411.1 ENSMUSG00000124541 (from geneSymbol) uc332mio.1 uc332mio.1 
ENSMUST00000264415.1 ENSMUSG00000124542 ENSMUST00000264415.1 ENSMUSG00000124542 (from geneSymbol) uc332mis.1 uc332mis.1 
ENSMUST00000264425.1 Gm9871 ENSMUST00000264425.1 Gm9871 (from geneSymbol) AK027905 uc332mjc.1 uc332mjc.1 
ENSMUST00000264427.1 ENSMUSG00000124543 ENSMUST00000264427.1 ENSMUSG00000124543 (from geneSymbol) uc332mje.1 uc332mje.1 
ENSMUST00000264429.1 ENSMUSG00000124544 ENSMUST00000264429.1 ENSMUSG00000124544 (from geneSymbol) AY860976 uc332mjg.1 uc332mjg.1 
ENSMUST00000264432.1 ENSMUSG00000124545 ENSMUST00000264432.1 ENSMUSG00000124545 (from geneSymbol) uc332mjj.1 uc332mjj.1 
ENSMUST00000264433.1 ENSMUSG00000124546 ENSMUST00000264433.1 ENSMUSG00000124546 (from geneSymbol) uc332mjk.1 uc332mjk.1 
ENSMUST00000264434.1 ENSMUSG00000124547 ENSMUST00000264434.1 ENSMUSG00000124547 (from geneSymbol) uc332mjl.1 uc332mjl.1 
ENSMUST00000264438.1 ENSMUSG00000124548 ENSMUST00000264438.1 ENSMUSG00000124548 (from geneSymbol) uc332mjp.1 uc332mjp.1 
ENSMUST00000264440.1 ENSMUSG00000124549 ENSMUST00000264440.1 ENSMUSG00000124549 (from geneSymbol) uc332mjr.1 uc332mjr.1 
ENSMUST00000264447.1 ENSMUSG00000124550 ENSMUST00000264447.1 ENSMUSG00000124550 (from geneSymbol) uc332mjy.1 uc332mjy.1 
ENSMUST00000264452.1 ENSMUSG00000124551 ENSMUST00000264452.1 ENSMUSG00000124551 (from geneSymbol) uc332mkd.1 uc332mkd.1 
ENSMUST00000264453.1 4930406D18Rik ENSMUST00000264453.1 4930406D18Rik (from geneSymbol) AK015105 uc332mke.1 uc332mke.1 
ENSMUST00000264458.1 Gm40155 ENSMUST00000264458.1 Gm40155 (from geneSymbol) uc332mkj.1 uc332mkj.1 
ENSMUST00000264477.1 ENSMUSG00000124552 ENSMUST00000264477.1 ENSMUSG00000124552 (from geneSymbol) uc332mlc.1 uc332mlc.1 
ENSMUST00000264478.1 ENSMUSG00000124553 ENSMUST00000264478.1 ENSMUSG00000124553 (from geneSymbol) uc332mld.1 uc332mld.1 
ENSMUST00000264479.1 ENSMUSG00000124554 ENSMUST00000264479.1 ENSMUSG00000124554 (from geneSymbol) uc332mle.1 uc332mle.1 
ENSMUST00000264480.1 ENSMUSG00000124555 ENSMUST00000264480.1 ENSMUSG00000124555 (from geneSymbol) uc332mlf.1 uc332mlf.1 
ENSMUST00000264481.1 Gm56957 ENSMUST00000264481.1 Gm56957 (from geneSymbol) uc332mlg.1 uc332mlg.1 
ENSMUST00000264483.1 ENSMUSG00000124556 ENSMUST00000264483.1 ENSMUSG00000124556 (from geneSymbol) AK076703 uc332mli.1 uc332mli.1 
ENSMUST00000264496.1 ENSMUSG00000124557 ENSMUST00000264496.1 ENSMUSG00000124557 (from geneSymbol) uc332mlv.1 uc332mlv.1 
ENSMUST00000264530.1 ENSMUSG00000124558 ENSMUST00000264530.1 ENSMUSG00000124558 (from geneSymbol) uc332mnd.1 uc332mnd.1 
ENSMUST00000264559.1 ENSMUSG00000124559 ENSMUST00000264559.1 ENSMUSG00000124559 (from geneSymbol) uc332mog.1 uc332mog.1 
ENSMUST00000264562.1 Gm46378 ENSMUST00000264562.1 Gm46378 (from geneSymbol) uc332moj.1 uc332moj.1 
ENSMUST00000264567.1 ENSMUSG00000124560 ENSMUST00000264567.1 ENSMUSG00000124560 (from geneSymbol) uc332moo.1 uc332moo.1 
ENSMUST00000264568.1 ENSMUSG00000124561 ENSMUST00000264568.1 ENSMUSG00000124561 (from geneSymbol) uc332mop.1 uc332mop.1 
ENSMUST00000264576.1 ENSMUSG00000124562 ENSMUST00000264576.1 ENSMUSG00000124562 (from geneSymbol) uc332mox.1 uc332mox.1 
ENSMUST00000264578.1 ENSMUSG00000124563 ENSMUST00000264578.1 ENSMUSG00000124563 (from geneSymbol) uc332moz.1 uc332moz.1 
ENSMUST00000264593.1 ENSMUSG00000124564 ENSMUST00000264593.1 ENSMUSG00000124564 (from geneSymbol) uc332mpo.1 uc332mpo.1 
ENSMUST00000264595.1 ENSMUSG00000124565 ENSMUST00000264595.1 ENSMUSG00000124565 (from geneSymbol) uc332mpq.1 uc332mpq.1 
ENSMUST00000264622.1 ENSMUSG00000124566 ENSMUST00000264622.1 ENSMUSG00000124566 (from geneSymbol) uc332mqr.1 uc332mqr.1 
ENSMUST00000264629.1 ENSMUSG00000124567 ENSMUST00000264629.1 ENSMUSG00000124567 (from geneSymbol) uc332mqy.1 uc332mqy.1 
ENSMUST00000264630.1 ENSMUSG00000124568 ENSMUST00000264630.1 ENSMUSG00000124568 (from geneSymbol) uc332mqz.1 uc332mqz.1 
ENSMUST00000264631.1 ENSMUSG00000124569 ENSMUST00000264631.1 ENSMUSG00000124569 (from geneSymbol) uc332mra.1 uc332mra.1 
ENSMUST00000264639.1 Gm13184 ENSMUST00000264639.1 Gm13184 (from geneSymbol) uc332mri.1 uc332mri.1 
ENSMUST00000264645.1 ENSMUSG00000121429 ENSMUST00000264645.1 ENSMUSG00000121429 (from geneSymbol) AK089995 uc332mro.1 uc332mro.1 
ENSMUST00000264662.1 ENSMUSG00000124570 ENSMUST00000264662.1 ENSMUSG00000124570 (from geneSymbol) uc332msf.1 uc332msf.1 
ENSMUST00000264663.1 ENSMUSG00000124571 ENSMUST00000264663.1 ENSMUSG00000124571 (from geneSymbol) uc332msg.1 uc332msg.1 
ENSMUST00000264668.1 ENSMUSG00000124573 ENSMUST00000264668.1 ENSMUSG00000124573 (from geneSymbol) uc332msk.1 uc332msk.1 
ENSMUST00000264671.1 ENSMUSG00000124574 ENSMUST00000264671.1 ENSMUSG00000124574 (from geneSymbol) uc332msn.1 uc332msn.1 
ENSMUST00000264704.1 ENSMUSG00000124575 ENSMUST00000264704.1 ENSMUSG00000124575 (from geneSymbol) uc332mtt.1 uc332mtt.1 
ENSMUST00000264705.1 Gm57062 ENSMUST00000264705.1 Gm57062 (from geneSymbol) uc332mtu.1 uc332mtu.1 
ENSMUST00000264712.1 Gm50386 ENSMUST00000264712.1 Gm50386 (from geneSymbol) uc332mub.1 uc332mub.1 
ENSMUST00000264719.1 ENSMUSG00000124576 ENSMUST00000264719.1 ENSMUSG00000124576 (from geneSymbol) uc332mui.1 uc332mui.1 
ENSMUST00000264720.1 ENSMUSG00000124577 ENSMUST00000264720.1 ENSMUSG00000124577 (from geneSymbol) uc332muj.1 uc332muj.1 
ENSMUST00000264721.1 ENSMUSG00000124578 ENSMUST00000264721.1 ENSMUSG00000124578 (from geneSymbol) uc332muk.1 uc332muk.1 
ENSMUST00000264734.1 Gm12474 ENSMUST00000264734.1 Gm12474 (from geneSymbol) AK053462 uc332mux.1 uc332mux.1 
ENSMUST00000264746.1 ENSMUSG00000124579 ENSMUST00000264746.1 ENSMUSG00000124579 (from geneSymbol) uc332mvj.1 uc332mvj.1 
ENSMUST00000264748.1 Gm57183 ENSMUST00000264748.1 Gm57183 (from geneSymbol) uc332mvl.1 uc332mvl.1 
ENSMUST00000264754.1 ENSMUSG00000124580 ENSMUST00000264754.1 ENSMUSG00000124580 (from geneSymbol) uc332mvr.1 uc332mvr.1 
ENSMUST00000264756.1 A730004F24Rik ENSMUST00000264756.1 A730004F24Rik (from geneSymbol) uc332mvt.1 uc332mvt.1 
ENSMUST00000264760.1 ENSMUSG00000124581 ENSMUST00000264760.1 ENSMUSG00000124581 (from geneSymbol) uc332mvx.1 uc332mvx.1 
ENSMUST00000264762.1 ENSMUSG00000124582 ENSMUST00000264762.1 ENSMUSG00000124582 (from geneSymbol) uc332mvz.1 uc332mvz.1 
ENSMUST00000264766.1 ENSMUSG00000124583 ENSMUST00000264766.1 ENSMUSG00000124583 (from geneSymbol) uc332mwd.1 uc332mwd.1 
ENSMUST00000264767.1 ENSMUSG00000124584 ENSMUST00000264767.1 ENSMUSG00000124584 (from geneSymbol) uc332mwe.1 uc332mwe.1 
ENSMUST00000264769.1 ENSMUSG00000124585 ENSMUST00000264769.1 ENSMUSG00000124585 (from geneSymbol) uc332mwg.1 uc332mwg.1 
ENSMUST00000264771.1 ENSMUSG00000124586 ENSMUST00000264771.1 ENSMUSG00000124586 (from geneSymbol) uc332mwi.1 uc332mwi.1 
ENSMUST00000264773.1 ENSMUSG00000124587 ENSMUST00000264773.1 ENSMUSG00000124587 (from geneSymbol) uc332mwk.1 uc332mwk.1 
ENSMUST00000264801.1 Gm3458 ENSMUST00000264801.1 Gm3458 (from geneSymbol) uc332mxm.1 uc332mxm.1 
ENSMUST00000264856.1 ENSMUSG00000124589 ENSMUST00000264856.1 ENSMUSG00000124589 (from geneSymbol) uc332mzp.1 uc332mzp.1 
ENSMUST00000264857.1 ENSMUSG00000124590 ENSMUST00000264857.1 ENSMUSG00000124590 (from geneSymbol) uc332mzq.1 uc332mzq.1 
ENSMUST00000264858.1 ENSMUSG00000124591 ENSMUST00000264858.1 ENSMUSG00000124591 (from geneSymbol) uc332mzr.1 uc332mzr.1 
ENSMUST00000264859.1 ENSMUSG00000124592 ENSMUST00000264859.1 ENSMUSG00000124592 (from geneSymbol) uc332mzs.1 uc332mzs.1 
ENSMUST00000264860.1 ENSMUSG00000124593 ENSMUST00000264860.1 ENSMUSG00000124593 (from geneSymbol) LF194688 uc332mzt.1 uc332mzt.1 
ENSMUST00000264861.1 ENSMUSG00000124594 ENSMUST00000264861.1 ENSMUSG00000124594 (from geneSymbol) uc332mzu.1 uc332mzu.1 
ENSMUST00000264865.1 ENSMUSG00000124595 ENSMUST00000264865.1 ENSMUSG00000124595 (from geneSymbol) uc332mzy.1 uc332mzy.1 
ENSMUST00000264872.1 ENSMUSG00000124596 ENSMUST00000264872.1 ENSMUSG00000124596 (from geneSymbol) uc332naf.1 uc332naf.1 
ENSMUST00000264873.1 ENSMUSG00000124597 ENSMUST00000264873.1 ENSMUSG00000124597 (from geneSymbol) uc332nag.1 uc332nag.1 
ENSMUST00000264874.1 ENSMUSG00000124598 ENSMUST00000264874.1 ENSMUSG00000124598 (from geneSymbol) uc332nah.1 uc332nah.1 
ENSMUST00000264876.1 ENSMUSG00000124599 ENSMUST00000264876.1 RIKEN cDNA B330016D10 gene (from RefSeq NR_030695.1) NR_030695 uc332naj.1 uc332naj.1 
ENSMUST00000264877.1 ENSMUSG00000124600 ENSMUST00000264877.1 ENSMUSG00000124600 (from geneSymbol) uc332nak.1 uc332nak.1 
ENSMUST00000264915.1 ENSMUSG00000124601 ENSMUST00000264915.1 ENSMUSG00000124601 (from geneSymbol) uc332nbw.1 uc332nbw.1 
ENSMUST00000264933.1 ENSMUSG00000124602 ENSMUST00000264933.1 ENSMUSG00000124602 (from geneSymbol) uc332nco.1 uc332nco.1 
ENSMUST00000264952.1 ENSMUSG00000124603 ENSMUST00000264952.1 ENSMUSG00000124603 (from geneSymbol) uc332ndh.1 uc332ndh.1 
ENSMUST00000264953.1 ENSMUSG00000124604 ENSMUST00000264953.1 ENSMUSG00000124604 (from geneSymbol) uc332ndi.1 uc332ndi.1 
ENSMUST00000264954.1 ENSMUSG00000124605 ENSMUST00000264954.1 ENSMUSG00000124605 (from geneSymbol) uc332ndj.1 uc332ndj.1 
ENSMUST00000264957.1 ENSMUSG00000124606 ENSMUST00000264957.1 ENSMUSG00000124606 (from geneSymbol) uc332ndm.1 uc332ndm.1 
ENSMUST00000264960.1 ENSMUSG00000124607 ENSMUST00000264960.1 ENSMUSG00000124607 (from geneSymbol) uc332ndp.1 uc332ndp.1 
ENSMUST00000264962.1 4930573C15Rik ENSMUST00000264962.1 4930573C15Rik (from geneSymbol) AK016288 uc332ndr.1 uc332ndr.1 
ENSMUST00000264971.1 ENSMUSG00000124608 ENSMUST00000264971.1 ENSMUSG00000124608 (from geneSymbol) uc332nea.1 uc332nea.1 
ENSMUST00000264973.1 ENSMUSG00000124609 ENSMUST00000264973.1 ENSMUSG00000124609 (from geneSymbol) uc332nec.1 uc332nec.1 
ENSMUST00000264974.1 Gm41836 ENSMUST00000264974.1 Gm41836 (from geneSymbol) uc332ned.1 uc332ned.1 
ENSMUST00000264983.1 ENSMUSG00000124610 ENSMUST00000264983.1 ENSMUSG00000124610 (from geneSymbol) uc332nem.1 uc332nem.1 
ENSMUST00000264984.1 ENSMUSG00000124611 ENSMUST00000264984.1 ENSMUSG00000124611 (from geneSymbol) uc332nen.1 uc332nen.1 
ENSMUST00000264987.1 Gm12676 ENSMUST00000264987.1 Gm12676 (from geneSymbol) AK047309 uc332neq.1 uc332neq.1 
ENSMUST00000264989.1 ENSMUSG00000124612 ENSMUST00000264989.1 ENSMUSG00000124612 (from geneSymbol) uc332nes.1 uc332nes.1 
ENSMUST00000264994.1 ENSMUSG00000124613 ENSMUST00000264994.1 ENSMUSG00000124613 (from geneSymbol) uc332nex.1 uc332nex.1 
ENSMUST00000264995.1 ENSMUSG00000124614 ENSMUST00000264995.1 ENSMUSG00000124614 (from geneSymbol) uc332ney.1 uc332ney.1 
ENSMUST00000264996.1 ENSMUSG00000124615 ENSMUST00000264996.1 ENSMUSG00000124615 (from geneSymbol) uc332nez.1 uc332nez.1 
ENSMUST00000264997.1 ENSMUSG00000124616 ENSMUST00000264997.1 ENSMUSG00000124616 (from geneSymbol) uc332nfa.1 uc332nfa.1 
ENSMUST00000264998.1 Gm41604 ENSMUST00000264998.1 Gm41604 (from geneSymbol) uc332nfb.1 uc332nfb.1 
ENSMUST00000264999.1 ENSMUSG00000124617 ENSMUST00000264999.1 ENSMUSG00000124617 (from geneSymbol) uc332nfc.1 uc332nfc.1 
ENSMUST00000265002.1 ENSMUSG00000124618 ENSMUST00000265002.1 ENSMUSG00000124618 (from geneSymbol) EU882234 uc332nfd.1 uc332nfd.1 
ENSMUST00000265010.1 ENSMUSG00000124619 ENSMUST00000265010.1 ENSMUSG00000124619 (from geneSymbol) uc332nfl.1 uc332nfl.1 
ENSMUST00000265037.1 ENSMUSG00000124620 ENSMUST00000265037.1 ENSMUSG00000124620 (from geneSymbol) uc332ngm.1 uc332ngm.1 
ENSMUST00000265043.1 ENSMUSG00000124621 ENSMUST00000265043.1 ENSMUSG00000124621 (from geneSymbol) uc332ngs.1 uc332ngs.1 
ENSMUST00000265046.1 ENSMUSG00000124622 ENSMUST00000265046.1 ENSMUSG00000124622 (from geneSymbol) BC099537 uc332ngv.1 uc332ngv.1 
ENSMUST00000265047.1 ENSMUSG00000124623 ENSMUST00000265047.1 ENSMUSG00000124623 (from geneSymbol) uc332ngw.1 uc332ngw.1 
ENSMUST00000265050.1 ENSMUSG00000124624 ENSMUST00000265050.1 ENSMUSG00000124624 (from geneSymbol) uc332ngz.1 uc332ngz.1 
ENSMUST00000265051.1 ENSMUSG00000124625 ENSMUST00000265051.1 ENSMUSG00000124625 (from geneSymbol) uc332nha.1 uc332nha.1 
ENSMUST00000265056.1 ENSMUSG00000124626 ENSMUST00000265056.1 ENSMUSG00000124626 (from geneSymbol) uc332nhf.1 uc332nhf.1 
ENSMUST00000265057.1 ENSMUSG00000124627 ENSMUST00000265057.1 ENSMUSG00000124627 (from geneSymbol) uc332nhg.1 uc332nhg.1 
ENSMUST00000265058.1 ENSMUSG00000124628 ENSMUST00000265058.1 ENSMUSG00000124628 (from geneSymbol) uc332nhh.1 uc332nhh.1 
ENSMUST00000265059.1 Gm35546 ENSMUST00000265059.1 Gm35546 (from geneSymbol) uc332nhi.1 uc332nhi.1 
ENSMUST00000265099.1 ENSMUSG00000124629 ENSMUST00000265099.1 ENSMUSG00000124629 (from geneSymbol) uc332niw.1 uc332niw.1 
ENSMUST00000265103.1 ENSMUSG00000124630 ENSMUST00000265103.1 ENSMUSG00000124630 (from geneSymbol) uc332nja.1 uc332nja.1 
ENSMUST00000265104.1 ENSMUSG00000124631 ENSMUST00000265104.1 ENSMUSG00000124631 (from geneSymbol) uc332njb.1 uc332njb.1 
ENSMUST00000265106.1 ENSMUSG00000124632 ENSMUST00000265106.1 ENSMUSG00000124632 (from geneSymbol) uc332njd.1 uc332njd.1 
ENSMUST00000265107.1 Gm36787 ENSMUST00000265107.1 Gm36787 (from geneSymbol) uc332nje.1 uc332nje.1 
ENSMUST00000265121.1 ENSMUSG00000124633 ENSMUST00000265121.1 ENSMUSG00000124633 (from geneSymbol) uc332njs.1 uc332njs.1 
ENSMUST00000265123.1 ENSMUSG00000124634 ENSMUST00000265123.1 ENSMUSG00000124634 (from geneSymbol) uc332nju.1 uc332nju.1 
ENSMUST00000265124.1 ENSMUSG00000124635 ENSMUST00000265124.1 ENSMUSG00000124635 (from geneSymbol) uc332njv.1 uc332njv.1 
ENSMUST00000265125.1 ENSMUSG00000124636 ENSMUST00000265125.1 ENSMUSG00000124636 (from geneSymbol) uc332njw.1 uc332njw.1 
ENSMUST00000265126.1 ENSMUSG00000124637 ENSMUST00000265126.1 ENSMUSG00000124637 (from geneSymbol) uc332njx.1 uc332njx.1 
ENSMUST00000265128.1 ENSMUSG00000124638 ENSMUST00000265128.1 ENSMUSG00000124638 (from geneSymbol) uc332njz.1 uc332njz.1 
ENSMUST00000265131.1 Gm2164 ENSMUST00000265131.1 Gm2164 (from geneSymbol) uc332nkc.1 uc332nkc.1 
ENSMUST00000265132.1 ENSMUSG00000124639 ENSMUST00000265132.1 ENSMUSG00000124639 (from geneSymbol) uc332nkd.1 uc332nkd.1 
ENSMUST00000265137.1 1700012C14Rik ENSMUST00000265137.1 1700012C14Rik (from geneSymbol) AK005895 uc332nki.1 uc332nki.1 
ENSMUST00000265147.1 ENSMUSG00000124640 ENSMUST00000265147.1 ENSMUSG00000124640 (from geneSymbol) uc332nks.1 uc332nks.1 
ENSMUST00000265148.1 ENSMUSG00000124641 ENSMUST00000265148.1 ENSMUSG00000124641 (from geneSymbol) uc332nkt.1 uc332nkt.1 
ENSMUST00000265149.1 ENSMUSG00000124642 ENSMUST00000265149.1 ENSMUSG00000124642 (from geneSymbol) uc332nku.1 uc332nku.1 
ENSMUST00000265162.1 ENSMUSG00000124643 ENSMUST00000265162.1 ENSMUSG00000124643 (from geneSymbol) uc332nlh.1 uc332nlh.1 
ENSMUST00000265177.1 Gm42882 ENSMUST00000265177.1 Gm42882 (from geneSymbol) uc332nlw.1 uc332nlw.1 
ENSMUST00000265181.1 ENSMUSG00000124644 ENSMUST00000265181.1 ENSMUSG00000124644 (from geneSymbol) uc332nma.1 uc332nma.1 
ENSMUST00000265185.1 ENSMUSG00000124646 ENSMUST00000265185.1 ENSMUSG00000124646 (from geneSymbol) uc332nmd.1 uc332nmd.1 
ENSMUST00000265189.1 ENSMUSG00000124647 ENSMUST00000265189.1 ENSMUSG00000124647 (from geneSymbol) uc332nmh.1 uc332nmh.1 
ENSMUST00000265192.1 ENSMUSG00000124648 ENSMUST00000265192.1 ENSMUSG00000124648 (from geneSymbol) FJ541078 uc332nmk.1 uc332nmk.1 
ENSMUST00000265198.1 ENSMUSG00000124649 ENSMUST00000265198.1 ENSMUSG00000124649 (from geneSymbol) uc332nmq.1 uc332nmq.1 
ENSMUST00000265199.1 ENSMUSG00000124650 ENSMUST00000265199.1 ENSMUSG00000124650 (from geneSymbol) uc332nmr.1 uc332nmr.1 
ENSMUST00000265203.1 ENSMUSG00000124651 ENSMUST00000265203.1 predicted gene, 31875 (from RefSeq NR_167768.1) NR_167768 uc332nmv.1 uc332nmv.1 
ENSMUST00000265216.1 4930578N18Rik ENSMUST00000265216.1 4930578N18Rik (from geneSymbol) AK019818 uc332nni.1 uc332nni.1 
ENSMUST00000265230.1 ENSMUSG00000124652 ENSMUST00000265230.1 ENSMUSG00000124652 (from geneSymbol) uc332nnw.1 uc332nnw.1 
ENSMUST00000265231.1 ENSMUSG00000124653 ENSMUST00000265231.1 ENSMUSG00000124653 (from geneSymbol) uc332nnx.1 uc332nnx.1 
ENSMUST00000265236.1 ENSMUSG00000124654 ENSMUST00000265236.1 ENSMUSG00000124654 (from geneSymbol) uc332noc.1 uc332noc.1 
ENSMUST00000265238.1 ENSMUSG00000124655 ENSMUST00000265238.1 ENSMUSG00000124655 (from geneSymbol) uc332noe.1 uc332noe.1 
ENSMUST00000265242.1 ENSMUSG00000124656 ENSMUST00000265242.1 ENSMUSG00000124656 (from geneSymbol) uc332noi.1 uc332noi.1 
ENSMUST00000265244.1 ENSMUSG00000124657 ENSMUST00000265244.1 ENSMUSG00000124657 (from geneSymbol) uc332nok.1 uc332nok.1 
ENSMUST00000265245.1 Gm39336 ENSMUST00000265245.1 Gm39336 (from geneSymbol) uc332nol.1 uc332nol.1 
ENSMUST00000265253.1 ENSMUSG00000124658 ENSMUST00000265253.1 ENSMUSG00000124658 (from geneSymbol) uc332not.1 uc332not.1 
ENSMUST00000265258.1 ENSMUSG00000124659 ENSMUST00000265258.1 ENSMUSG00000124659 (from geneSymbol) uc332noy.1 uc332noy.1 
ENSMUST00000265259.1 ENSMUSG00000124660 ENSMUST00000265259.1 ENSMUSG00000124660 (from geneSymbol) uc332noz.1 uc332noz.1 
ENSMUST00000265269.1 ENSMUSG00000124661 ENSMUST00000265269.1 ENSMUSG00000124661 (from geneSymbol) uc332npi.1 uc332npi.1 
ENSMUST00000265284.1 ENSMUSG00000124662 ENSMUST00000265284.1 ENSMUSG00000124662 (from geneSymbol) uc332npx.1 uc332npx.1 
ENSMUST00000265286.1 ENSMUSG00000124663 ENSMUST00000265286.1 ENSMUSG00000124663 (from geneSymbol) uc332npy.1 uc332npy.1 
ENSMUST00000265293.1 ENSMUSG00000124664 ENSMUST00000265293.1 ENSMUSG00000124664 (from geneSymbol) uc332nqf.1 uc332nqf.1 
ENSMUST00000265294.1 Gm13657 ENSMUST00000265294.1 Gm13657 (from geneSymbol) AK035219 uc332nqg.1 uc332nqg.1 
ENSMUST00000265314.1 1700025N23Rik ENSMUST00000265314.1 1700025N23Rik (from geneSymbol) AK006361 uc332nra.1 uc332nra.1 
ENSMUST00000265325.1 ENSMUSG00000124665 ENSMUST00000265325.1 ENSMUSG00000124665 (from geneSymbol) uc332nrl.1 uc332nrl.1 
ENSMUST00000265326.1 ENSMUSG00000124666 ENSMUST00000265326.1 ENSMUSG00000124666 (from geneSymbol) uc332nrm.1 uc332nrm.1 
ENSMUST00000265327.1 ENSMUSG00000124667 ENSMUST00000265327.1 ENSMUSG00000124667 (from geneSymbol) uc332nrn.1 uc332nrn.1 
ENSMUST00000265330.1 ENSMUSG00000124668 ENSMUST00000265330.1 ENSMUSG00000124668 (from geneSymbol) uc332nrq.1 uc332nrq.1 
ENSMUST00000265341.1 ENSMUSG00000124669 ENSMUST00000265341.1 ENSMUSG00000124669 (from geneSymbol) uc332nsb.1 uc332nsb.1 
ENSMUST00000265342.1 ENSMUSG00000124670 ENSMUST00000265342.1 ENSMUSG00000124670 (from geneSymbol) uc332nsc.1 uc332nsc.1 
ENSMUST00000265344.1 ENSMUSG00000124671 ENSMUST00000265344.1 ENSMUSG00000124671 (from geneSymbol) uc332nse.1 uc332nse.1 
ENSMUST00000265352.1 2310015A16Rik ENSMUST00000265352.1 2310015A16Rik (from geneSymbol) AK009349 uc332nsl.1 uc332nsl.1 
ENSMUST00000265359.1 ENSMUSG00000124672 ENSMUST00000265359.1 ENSMUSG00000124672 (from geneSymbol) uc332nss.1 uc332nss.1 
ENSMUST00000265376.1 ENSMUSG00000124674 ENSMUST00000265376.1 ENSMUSG00000124674 (from geneSymbol) uc332nti.1 uc332nti.1 
ENSMUST00000265379.1 ENSMUSG00000124675 ENSMUST00000265379.1 ENSMUSG00000124675 (from geneSymbol) uc332ntl.1 uc332ntl.1 
ENSMUST00000265380.1 ENSMUSG00000124676 ENSMUST00000265380.1 ENSMUSG00000124676 (from geneSymbol) uc332ntm.1 uc332ntm.1 
ENSMUST00000265382.1 ENSMUSG00000124677 ENSMUST00000265382.1 ENSMUSG00000124677 (from geneSymbol) uc332nto.1 uc332nto.1 
ENSMUST00000265385.1 ENSMUSG00000124678 ENSMUST00000265385.1 ENSMUSG00000124678 (from geneSymbol) uc332ntr.1 uc332ntr.1 
ENSMUST00000265386.1 ENSMUSG00000124679 ENSMUST00000265386.1 ENSMUSG00000124679 (from geneSymbol) uc332nts.1 uc332nts.1 
ENSMUST00000265390.1 ENSMUSG00000124681 ENSMUST00000265390.1 ENSMUSG00000124681 (from geneSymbol) uc332ntt.1 uc332ntt.1 
ENSMUST00000265395.1 ENSMUSG00000124682 ENSMUST00000265395.1 ENSMUSG00000124682 (from geneSymbol) uc332nty.1 uc332nty.1 
ENSMUST00000265399.1 ENSMUSG00000124683 ENSMUST00000265399.1 ENSMUSG00000124683 (from geneSymbol) uc332nuc.1 uc332nuc.1 
ENSMUST00000265410.1 ENSMUSG00000124684 ENSMUST00000265410.1 ENSMUSG00000124684 (from geneSymbol) uc332nun.1 uc332nun.1 
ENSMUST00000265414.1 ENSMUSG00000124685 ENSMUST00000265414.1 ENSMUSG00000124685 (from geneSymbol) uc332nur.1 uc332nur.1 
ENSMUST00000265415.1 ENSMUSG00000124686 ENSMUST00000265415.1 ENSMUSG00000124686 (from geneSymbol) uc332nus.1 uc332nus.1 
ENSMUST00000265419.1 ENSMUSG00000124688 ENSMUST00000265419.1 ENSMUSG00000124688 (from geneSymbol) uc332nuv.1 uc332nuv.1 
ENSMUST00000265421.1 ENSMUSG00000124689 ENSMUST00000265421.1 ENSMUSG00000124689 (from geneSymbol) uc332nux.1 uc332nux.1 
ENSMUST00000265422.1 ENSMUSG00000124690 ENSMUST00000265422.1 ENSMUSG00000124690 (from geneSymbol) uc332nuy.1 uc332nuy.1 
ENSMUST00000265425.1 ENSMUSG00000124691 ENSMUST00000265425.1 ENSMUSG00000124691 (from geneSymbol) uc332nvb.1 uc332nvb.1 
ENSMUST00000265427.1 ENSMUSG00000124692 ENSMUST00000265427.1 ENSMUSG00000124692 (from geneSymbol) uc332nvd.1 uc332nvd.1 
ENSMUST00000265428.1 ENSMUSG00000124693 ENSMUST00000265428.1 ENSMUSG00000124693 (from geneSymbol) uc332nve.1 uc332nve.1 
ENSMUST00000265432.1 ENSMUSG00000124694 ENSMUST00000265432.1 ENSMUSG00000124694 (from geneSymbol) uc332nvi.1 uc332nvi.1 
ENSMUST00000265433.1 ENSMUSG00000124695 ENSMUST00000265433.1 ENSMUSG00000124695 (from geneSymbol) uc332nvj.1 uc332nvj.1 
ENSMUST00000265435.1 ENSMUSG00000124696 ENSMUST00000265435.1 ENSMUSG00000124696 (from geneSymbol) uc332nvl.1 uc332nvl.1 
ENSMUST00000265442.1 ENSMUSG00000124697 ENSMUST00000265442.1 ENSMUSG00000124697 (from geneSymbol) uc332nvs.1 uc332nvs.1 
ENSMUST00000265450.1 Gm10535 ENSMUST00000265450.1 Gm10535 (from geneSymbol) AK134881 uc332nwa.1 uc332nwa.1 
ENSMUST00000265456.1 ENSMUSG00000124698 ENSMUST00000265456.1 ENSMUSG00000124698 (from geneSymbol) uc332nwg.1 uc332nwg.1 
ENSMUST00000265457.1 ENSMUSG00000124699 ENSMUST00000265457.1 ENSMUSG00000124699 (from geneSymbol) uc332nwh.1 uc332nwh.1 
ENSMUST00000265460.1 ENSMUSG00000124700 ENSMUST00000265460.1 ENSMUSG00000124700 (from geneSymbol) uc332nwk.1 uc332nwk.1 
ENSMUST00000265465.1 ENSMUSG00000124701 ENSMUST00000265465.1 ENSMUSG00000124701 (from geneSymbol) uc332nwp.1 uc332nwp.1 
ENSMUST00000265469.1 ENSMUSG00000124702 ENSMUST00000265469.1 ENSMUSG00000124702 (from geneSymbol) uc332nwt.1 uc332nwt.1 
ENSMUST00000265473.1 Gm49468 ENSMUST00000265473.1 Gm49468 (from geneSymbol) uc332nwx.1 uc332nwx.1 
ENSMUST00000265477.1 ENSMUSG00000124703 ENSMUST00000265477.1 ENSMUSG00000124703 (from geneSymbol) uc332nxb.1 uc332nxb.1 
ENSMUST00000265481.1 ENSMUSG00000124704 ENSMUST00000265481.1 ENSMUSG00000124704 (from geneSymbol) uc332nxf.1 uc332nxf.1 
ENSMUST00000265494.1 ENSMUSG00000124705 ENSMUST00000265494.1 ENSMUSG00000124705 (from geneSymbol) uc332nxs.1 uc332nxs.1 
ENSMUST00000265497.1 ENSMUSG00000124707 ENSMUST00000265497.1 ENSMUSG00000124707 (from geneSymbol) uc332nxu.1 uc332nxu.1 
ENSMUST00000265500.1 ENSMUSG00000124708 ENSMUST00000265500.1 ENSMUSG00000124708 (from geneSymbol) uc332nxx.1 uc332nxx.1 
ENSMUST00000265501.1 ENSMUSG00000124709 ENSMUST00000265501.1 ENSMUSG00000124709 (from geneSymbol) uc332nxy.1 uc332nxy.1 
ENSMUST00000265503.1 ENSMUSG00000124710 ENSMUST00000265503.1 ENSMUSG00000124710 (from geneSymbol) uc332nya.1 uc332nya.1 
ENSMUST00000265509.1 ENSMUSG00000124711 ENSMUST00000265509.1 ENSMUSG00000124711 (from geneSymbol) uc332nyg.1 uc332nyg.1 
ENSMUST00000265510.1 ENSMUSG00000124712 ENSMUST00000265510.1 ENSMUSG00000124712 (from geneSymbol) uc332nyh.1 uc332nyh.1 
ENSMUST00000265512.1 ENSMUSG00000124713 ENSMUST00000265512.1 ENSMUSG00000124713 (from geneSymbol) uc332nyj.1 uc332nyj.1 
ENSMUST00000265516.1 ENSMUSG00000124714 ENSMUST00000265516.1 ENSMUSG00000124714 (from geneSymbol) AK077083 uc332nyn.1 uc332nyn.1 
ENSMUST00000265517.1 Gm36992 ENSMUST00000265517.1 Gm36992 (from geneSymbol) uc332nyo.1 uc332nyo.1 
ENSMUST00000265533.1 ENSMUSG00000124715 ENSMUST00000265533.1 ENSMUSG00000124715 (from geneSymbol) uc332nze.1 uc332nze.1 
ENSMUST00000265544.1 ENSMUSG00000124716 ENSMUST00000265544.1 ENSMUSG00000124716 (from geneSymbol) uc332nzp.1 uc332nzp.1 
ENSMUST00000265548.1 Gm30509 ENSMUST00000265548.1 Gm30509 (from geneSymbol) uc332nzt.1 uc332nzt.1 
ENSMUST00000265556.1 ENSMUSG00000124717 ENSMUST00000265556.1 ENSMUSG00000124717 (from geneSymbol) uc332oab.1 uc332oab.1 
ENSMUST00000265562.1 ENSMUSG00000124718 ENSMUST00000265562.1 ENSMUSG00000124718 (from geneSymbol) uc332oah.1 uc332oah.1 
ENSMUST00000265563.1 ENSMUSG00000124719 ENSMUST00000265563.1 ENSMUSG00000124719 (from geneSymbol) uc332oai.1 uc332oai.1 
ENSMUST00000265564.1 Gm48768 ENSMUST00000265564.1 Gm48768 (from geneSymbol) uc332oaj.1 uc332oaj.1 
ENSMUST00000265581.1 ENSMUSG00000124720 ENSMUST00000265581.1 ENSMUSG00000124720 (from geneSymbol) uc332oba.1 uc332oba.1 
ENSMUST00000265605.1 Gm33340 ENSMUST00000265605.1 Gm33340 (from geneSymbol) uc332obh.1 uc332obh.1 
ENSMUST00000265609.1 Gm13563 ENSMUST00000265609.1 Gm13563 (from geneSymbol) uc332obl.1 uc332obl.1 
ENSMUST00000265610.1 ENSMUSG00000124722 ENSMUST00000265610.1 ENSMUSG00000124722 (from geneSymbol) LF194731 uc332obm.1 uc332obm.1 
ENSMUST00000265611.1 ENSMUSG00000124723 ENSMUST00000265611.1 ENSMUSG00000124723 (from geneSymbol) uc332obn.1 uc332obn.1 
ENSMUST00000265613.1 Gm29478 ENSMUST00000265613.1 Gm29478 (from geneSymbol) uc332obp.1 uc332obp.1 
ENSMUST00000265621.1 ENSMUSG00000124724 ENSMUST00000265621.1 ENSMUSG00000124724 (from geneSymbol) uc332obx.1 uc332obx.1 
ENSMUST00000265624.1 ENSMUSG00000124726 ENSMUST00000265624.1 ENSMUSG00000124726 (from geneSymbol) uc332obz.1 uc332obz.1 
ENSMUST00000265630.1 Gm4146 ENSMUST00000265630.1 Gm4146 (from geneSymbol) AK043255 uc332ocf.1 uc332ocf.1 
ENSMUST00000265633.1 ENSMUSG00000124727 ENSMUST00000265633.1 ENSMUSG00000124727 (from geneSymbol) uc332oci.1 uc332oci.1 
ENSMUST00000265634.1 ENSMUSG00000124728 ENSMUST00000265634.1 ENSMUSG00000124728 (from geneSymbol) uc332ocj.1 uc332ocj.1 
ENSMUST00000265636.1 ENSMUSG00000124729 ENSMUST00000265636.1 ENSMUSG00000124729 (from geneSymbol) uc332ocl.1 uc332ocl.1 
ENSMUST00000265637.1 ENSMUSG00000124730 ENSMUST00000265637.1 ENSMUSG00000124730 (from geneSymbol) uc332ocm.1 uc332ocm.1 
ENSMUST00000265644.1 ENSMUSG00000124731 ENSMUST00000265644.1 ENSMUSG00000124731 (from geneSymbol) uc332oct.1 uc332oct.1 
ENSMUST00000265656.1 ENSMUSG00000124732 ENSMUST00000265656.1 ENSMUSG00000124732 (from geneSymbol) uc332odf.1 uc332odf.1 
ENSMUST00000265657.1 ENSMUSG00000124733 ENSMUST00000265657.1 ENSMUSG00000124733 (from geneSymbol) uc332odg.1 uc332odg.1 
ENSMUST00000265664.1 ENSMUSG00000124734 ENSMUST00000265664.1 ENSMUSG00000124734 (from geneSymbol) uc332odn.1 uc332odn.1 
ENSMUST00000265669.1 ENSMUSG00000124735 ENSMUST00000265669.1 ENSMUSG00000124735 (from geneSymbol) uc332ods.1 uc332ods.1 
ENSMUST00000265674.1 ENSMUSG00000124736 ENSMUST00000265674.1 ENSMUSG00000124736 (from geneSymbol) uc332odx.1 uc332odx.1 
ENSMUST00000265676.1 ENSMUSG00000124737 ENSMUST00000265676.1 ENSMUSG00000124737 (from geneSymbol) uc332odz.1 uc332odz.1 
ENSMUST00000265677.1 ENSMUSG00000124738 ENSMUST00000265677.1 ENSMUSG00000124738 (from geneSymbol) uc332oea.1 uc332oea.1 
ENSMUST00000265680.1 ENSMUSG00000124739 ENSMUST00000265680.1 ENSMUSG00000124739 (from geneSymbol) uc332oed.1 uc332oed.1 
ENSMUST00000265682.1 ENSMUSG00000124740 ENSMUST00000265682.1 ENSMUSG00000124740 (from geneSymbol) uc332oef.1 uc332oef.1 
ENSMUST00000265686.1 Gm30339 ENSMUST00000265686.1 Gm30339 (from geneSymbol) uc332oej.1 uc332oej.1 
ENSMUST00000265689.1 Gm37184 ENSMUST00000265689.1 Gm37184 (from geneSymbol) uc332oem.1 uc332oem.1 
ENSMUST00000265698.1 Gm49208 ENSMUST00000265698.1 Gm49208 (from geneSymbol) uc332oev.1 uc332oev.1 
ENSMUST00000265706.1 ENSMUSG00000124741 ENSMUST00000265706.1 ENSMUSG00000124741 (from geneSymbol) uc332ofd.1 uc332ofd.1 
ENSMUST00000265707.1 ENSMUSG00000124742 ENSMUST00000265707.1 ENSMUSG00000124742 (from geneSymbol) uc332ofe.1 uc332ofe.1 
ENSMUST00000265729.1 Gm56830 ENSMUST00000265729.1 Gm56830 (from geneSymbol) uc332ofz.1 uc332ofz.1 
ENSMUST00000265734.1 ENSMUSG00000124743 ENSMUST00000265734.1 ENSMUSG00000124743 (from geneSymbol) uc332oge.1 uc332oge.1 
ENSMUST00000265737.1 ENSMUSG00000124744 ENSMUST00000265737.1 ENSMUSG00000124744 (from geneSymbol) uc332ogh.1 uc332ogh.1 
ENSMUST00000265739.1 ENSMUSG00000124745 ENSMUST00000265739.1 ENSMUSG00000124745 (from geneSymbol) uc332ogj.1 uc332ogj.1 
ENSMUST00000265740.1 ENSMUSG00000124746 ENSMUST00000265740.1 ENSMUSG00000124746 (from geneSymbol) uc332ogk.1 uc332ogk.1 
ENSMUST00000265741.1 ENSMUSG00000124747 ENSMUST00000265741.1 ENSMUSG00000124747 (from geneSymbol) uc332ogl.1 uc332ogl.1 
ENSMUST00000265742.1 ENSMUSG00000124748 ENSMUST00000265742.1 ENSMUSG00000124748 (from geneSymbol) uc332ogm.1 uc332ogm.1 
ENSMUST00000265743.1 ENSMUSG00000124749 ENSMUST00000265743.1 ENSMUSG00000124749 (from geneSymbol) uc332ogn.1 uc332ogn.1 
ENSMUST00000265747.1 ENSMUSG00000124750 ENSMUST00000265747.1 ENSMUSG00000124750 (from geneSymbol) uc332ogr.1 uc332ogr.1 
ENSMUST00000265748.1 ENSMUSG00000124751 ENSMUST00000265748.1 ENSMUSG00000124751 (from geneSymbol) uc332ogs.1 uc332ogs.1 
ENSMUST00000265749.1 ENSMUSG00000124752 ENSMUST00000265749.1 ENSMUSG00000124752 (from geneSymbol) uc332ogt.1 uc332ogt.1 
ENSMUST00000265750.1 ENSMUSG00000124753 ENSMUST00000265750.1 ENSMUSG00000124753 (from geneSymbol) EF591879 uc332ogu.1 uc332ogu.1 
ENSMUST00000265772.1 ENSMUSG00000124754 ENSMUST00000265772.1 ENSMUSG00000124754 (from geneSymbol) uc332ohq.1 uc332ohq.1 
ENSMUST00000265773.1 ENSMUSG00000124755 ENSMUST00000265773.1 ENSMUSG00000124755 (from geneSymbol) uc332ohr.1 uc332ohr.1 
ENSMUST00000265777.1 ENSMUSG00000124756 ENSMUST00000265777.1 ENSMUSG00000124756 (from geneSymbol) uc332ohv.1 uc332ohv.1 
ENSMUST00000265780.1 ENSMUSG00000124757 ENSMUST00000265780.1 ENSMUSG00000124757 (from geneSymbol) uc332ohy.1 uc332ohy.1 
ENSMUST00000265781.1 ENSMUSG00000124758 ENSMUST00000265781.1 ENSMUSG00000124758 (from geneSymbol) uc332ohz.1 uc332ohz.1 
ENSMUST00000265791.1 ENSMUSG00000124759 ENSMUST00000265791.1 ENSMUSG00000124759 (from geneSymbol) uc332oij.1 uc332oij.1 
ENSMUST00000265792.1 ENSMUSG00000124760 ENSMUST00000265792.1 ENSMUSG00000124760 (from geneSymbol) uc332oik.1 uc332oik.1 
ENSMUST00000265793.1 ENSMUSG00000124761 ENSMUST00000265793.1 ENSMUSG00000124761 (from geneSymbol) uc332oil.1 uc332oil.1 
ENSMUST00000265794.1 ENSMUSG00000124762 ENSMUST00000265794.1 ENSMUSG00000124762 (from geneSymbol) uc332oim.1 uc332oim.1 
ENSMUST00000265796.1 ENSMUSG00000124763 ENSMUST00000265796.1 ENSMUSG00000124763 (from geneSymbol) uc332oio.1 uc332oio.1 
ENSMUST00000265802.1 ENSMUSG00000124764 ENSMUST00000265802.1 ENSMUSG00000124764 (from geneSymbol) uc332oiu.1 uc332oiu.1 
ENSMUST00000265804.1 ENSMUSG00000124765 ENSMUST00000265804.1 ENSMUSG00000124765 (from geneSymbol) uc332oiw.1 uc332oiw.1 
ENSMUST00000265805.1 ENSMUSG00000124766 ENSMUST00000265805.1 ENSMUSG00000124766 (from geneSymbol) uc332oix.1 uc332oix.1 
ENSMUST00000265807.1 ENSMUSG00000124767 ENSMUST00000265807.1 ENSMUSG00000124767 (from geneSymbol) uc332oiz.1 uc332oiz.1 
ENSMUST00000265808.1 ENSMUSG00000124768 ENSMUST00000265808.1 ENSMUSG00000124768 (from geneSymbol) uc332oja.1 uc332oja.1 
ENSMUST00000265809.1 ENSMUSG00000124769 ENSMUST00000265809.1 ENSMUSG00000124769 (from geneSymbol) uc332ojb.1 uc332ojb.1 
ENSMUST00000265810.1 Gm30230 ENSMUST00000265810.1 Gm30230 (from geneSymbol) uc332ojc.1 uc332ojc.1 
ENSMUST00000265813.1 ENSMUSG00000124770 ENSMUST00000265813.1 ENSMUSG00000124770 (from geneSymbol) uc332ojf.1 uc332ojf.1 
ENSMUST00000265821.1 ENSMUSG00000124771 ENSMUST00000265821.1 ENSMUSG00000124771 (from geneSymbol) uc332ojm.1 uc332ojm.1 
ENSMUST00000265822.1 ENSMUSG00000124772 ENSMUST00000265822.1 ENSMUSG00000124772 (from geneSymbol) uc332ojn.1 uc332ojn.1 
ENSMUST00000265825.1 Gm14341 ENSMUST00000265825.1 Gm14341 (from geneSymbol) AK040057 uc332ojq.1 uc332ojq.1 
ENSMUST00000265826.1 ENSMUSG00000124773 ENSMUST00000265826.1 ENSMUSG00000124773 (from geneSymbol) LF194317 uc332ojr.1 uc332ojr.1 
ENSMUST00000265827.1 ENSMUSG00000124774 ENSMUST00000265827.1 ENSMUSG00000124774 (from geneSymbol) AK014815 uc332ojs.1 uc332ojs.1 
ENSMUST00000265828.1 ENSMUSG00000124775 ENSMUST00000265828.1 ENSMUSG00000124775 (from geneSymbol) uc332ojt.1 uc332ojt.1 
ENSMUST00000265834.1 Gm41386 ENSMUST00000265834.1 Gm41386 (from geneSymbol) uc332ojz.1 uc332ojz.1 
ENSMUST00000265837.1 ENSMUSG00000124776 ENSMUST00000265837.1 ENSMUSG00000124776 (from geneSymbol) uc332okc.1 uc332okc.1 
ENSMUST00000265840.1 ENSMUSG00000124777 ENSMUST00000265840.1 ENSMUSG00000124777 (from geneSymbol) uc332okf.1 uc332okf.1 
ENSMUST00000265841.1 ENSMUSG00000124778 ENSMUST00000265841.1 ENSMUSG00000124778 (from geneSymbol) LF198132 uc332okg.1 uc332okg.1 
ENSMUST00000265847.1 ENSMUSG00000124779 ENSMUST00000265847.1 ENSMUSG00000124779 (from geneSymbol) uc332okm.1 uc332okm.1 
ENSMUST00000265849.1 Gm31497 ENSMUST00000265849.1 Gm31497 (from geneSymbol) uc332oko.1 uc332oko.1 
ENSMUST00000265862.1 ENSMUSG00000124780 ENSMUST00000265862.1 ENSMUSG00000124780 (from geneSymbol) uc332olb.1 uc332olb.1 
ENSMUST00000265863.1 ENSMUSG00000124781 ENSMUST00000265863.1 ENSMUSG00000124781 (from geneSymbol) uc332olc.1 uc332olc.1 
ENSMUST00000265864.1 ENSMUSG00000124782 ENSMUST00000265864.1 ENSMUSG00000124782 (from geneSymbol) uc332old.1 uc332old.1 
ENSMUST00000265866.1 ENSMUSG00000124783 ENSMUST00000265866.1 ENSMUSG00000124783 (from geneSymbol) uc332olf.1 uc332olf.1 
ENSMUST00000265867.1 ENSMUSG00000124784 ENSMUST00000265867.1 ENSMUSG00000124784 (from geneSymbol) uc332olg.1 uc332olg.1 
ENSMUST00000265868.1 ENSMUSG00000124785 ENSMUST00000265868.1 ENSMUSG00000124785 (from geneSymbol) uc332olh.1 uc332olh.1 
ENSMUST00000265870.1 ENSMUSG00000124786 ENSMUST00000265870.1 ENSMUSG00000124786 (from geneSymbol) uc332olj.1 uc332olj.1 
ENSMUST00000265871.1 ENSMUSG00000124787 ENSMUST00000265871.1 ENSMUSG00000124787 (from geneSymbol) uc332olk.1 uc332olk.1 
ENSMUST00000265874.1 Gm26964 ENSMUST00000265874.1 Gm26964 (from geneSymbol) uc332oln.1 uc332oln.1 
ENSMUST00000265880.1 ENSMUSG00000124788 ENSMUST00000265880.1 ENSMUSG00000124788 (from geneSymbol) LF201124 uc332olt.1 uc332olt.1 
ENSMUST00000265882.1 ENSMUSG00000124789 ENSMUST00000265882.1 ENSMUSG00000124789 (from geneSymbol) uc332olv.1 uc332olv.1 
ENSMUST00000265884.1 ENSMUSG00000121433 ENSMUST00000265884.1 ENSMUSG00000121433 (from geneSymbol) uc332olx.1 uc332olx.1 
ENSMUST00000265886.1 Pdxk-ps ENSMUST00000265886.1 Pdxk-ps (from geneSymbol) AK138248 uc332olz.1 uc332olz.1 
ENSMUST00000265898.1 ENSMUSG00000124790 ENSMUST00000265898.1 ENSMUSG00000124790 (from geneSymbol) uc332oml.1 uc332oml.1 
ENSMUST00000265901.1 ENSMUSG00000124791 ENSMUST00000265901.1 ENSMUSG00000124791 (from geneSymbol) uc332omo.1 uc332omo.1 
ENSMUST00000265902.1 ENSMUSG00000124792 ENSMUST00000265902.1 ENSMUSG00000124792 (from geneSymbol) LF201426 uc332omp.1 uc332omp.1 
ENSMUST00000265903.1 ENSMUSG00000124793 ENSMUST00000265903.1 ENSMUSG00000124793 (from geneSymbol) uc332omq.1 uc332omq.1 
ENSMUST00000265906.1 ENSMUSG00000124794 ENSMUST00000265906.1 ENSMUSG00000124794 (from geneSymbol) uc332omt.1 uc332omt.1 
ENSMUST00000265907.1 ENSMUSG00000124795 ENSMUST00000265907.1 ENSMUSG00000124795 (from geneSymbol) uc332omu.1 uc332omu.1 
ENSMUST00000265908.1 ENSMUSG00000124796 ENSMUST00000265908.1 ENSMUSG00000124796 (from geneSymbol) uc332omv.1 uc332omv.1 
ENSMUST00000265909.1 ENSMUSG00000124797 ENSMUST00000265909.1 ENSMUSG00000124797 (from geneSymbol) uc332omw.1 uc332omw.1 
ENSMUST00000265910.1 Gm56874 ENSMUST00000265910.1 RIKEN cDNA 4930522P08 gene (from RefSeq NR_151735.1) NR_151735 uc332omx.1 uc332omx.1 
ENSMUST00000265914.1 ENSMUSG00000124798 ENSMUST00000265914.1 ENSMUSG00000124798 (from geneSymbol) uc332ona.1 uc332ona.1 
ENSMUST00000265915.1 ENSMUSG00000124799 ENSMUST00000265915.1 ENSMUSG00000124799 (from geneSymbol) uc332onb.1 uc332onb.1 
ENSMUST00000265916.1 ENSMUSG00000124800 ENSMUST00000265916.1 ENSMUSG00000124800 (from geneSymbol) uc332onc.1 uc332onc.1 
ENSMUST00000265920.1 Gm40709 ENSMUST00000265920.1 Gm40709 (from geneSymbol) uc332ong.1 uc332ong.1 
ENSMUST00000265936.1 Gm29089 ENSMUST00000265936.1 Gm29089 (from geneSymbol) KC170991 uc332ont.1 uc332ont.1 
ENSMUST00000265941.1 ENSMUSG00000124803 ENSMUST00000265941.1 ENSMUSG00000124803 (from geneSymbol) uc332ony.1 uc332ony.1 
ENSMUST00000265942.1 ENSMUSG00000124804 ENSMUST00000265942.1 ENSMUSG00000124804 (from geneSymbol) uc332onz.1 uc332onz.1 
ENSMUST00000265943.1 ENSMUSG00000124805 ENSMUST00000265943.1 ENSMUSG00000124805 (from geneSymbol) uc332ooa.1 uc332ooa.1 
ENSMUST00000265949.1 ENSMUSG00000124806 ENSMUST00000265949.1 ENSMUSG00000124806 (from geneSymbol) uc332oog.1 uc332oog.1 
ENSMUST00000265959.1 ENSMUSG00000124807 ENSMUST00000265959.1 ENSMUSG00000124807 (from geneSymbol) uc332ooq.1 uc332ooq.1 
ENSMUST00000265965.1 Gm17501 ENSMUST00000265965.1 Gm17501 (from geneSymbol) FJ422280 uc332oow.1 uc332oow.1 
ENSMUST00000265975.1 ENSMUSG00000124808 ENSMUST00000265975.1 ENSMUSG00000124808 (from geneSymbol) uc332opg.1 uc332opg.1 
ENSMUST00000265976.1 ENSMUSG00000124809 ENSMUST00000265976.1 ENSMUSG00000124809 (from geneSymbol) uc332oph.1 uc332oph.1 
ENSMUST00000265980.1 Gm39150 ENSMUST00000265980.1 Gm39150 (from geneSymbol) uc332opl.1 uc332opl.1 
ENSMUST00000265996.1 ENSMUSG00000124810 ENSMUST00000265996.1 ENSMUSG00000124810 (from geneSymbol) uc332oqb.1 uc332oqb.1 
ENSMUST00000265998.1 ENSMUSG00000124811 ENSMUST00000265998.1 ENSMUSG00000124811 (from geneSymbol) uc332oqd.1 uc332oqd.1 
ENSMUST00000266001.1 ENSMUSG00000124812 ENSMUST00000266001.1 ENSMUSG00000124812 (from geneSymbol) uc332oqg.1 uc332oqg.1 
ENSMUST00000266003.1 ENSMUSG00000124813 ENSMUST00000266003.1 ENSMUSG00000124813 (from geneSymbol) uc332oqi.1 uc332oqi.1 
ENSMUST00000266005.1 ENSMUSG00000124814 ENSMUST00000266005.1 ENSMUSG00000124814 (from geneSymbol) uc332oqk.1 uc332oqk.1 
ENSMUST00000266007.1 ENSMUSG00000124815 ENSMUST00000266007.1 ENSMUSG00000124815 (from geneSymbol) uc332oqm.1 uc332oqm.1 
ENSMUST00000266008.1 4930579P08Rik ENSMUST00000266008.1 4930579P08Rik (from geneSymbol) AK016333 uc332oqn.1 uc332oqn.1 
ENSMUST00000266013.1 ENSMUSG00000124816 ENSMUST00000266013.1 ENSMUSG00000124816 (from geneSymbol) uc332oqs.1 uc332oqs.1 
ENSMUST00000266014.1 ENSMUSG00000124817 ENSMUST00000266014.1 ENSMUSG00000124817 (from geneSymbol) uc332oqt.1 uc332oqt.1 
ENSMUST00000266023.1 ENSMUSG00000124818 ENSMUST00000266023.1 ENSMUSG00000124818 (from geneSymbol) uc332orc.1 uc332orc.1 
ENSMUST00000266025.1 ENSMUSG00000124819 ENSMUST00000266025.1 ENSMUSG00000124819 (from geneSymbol) uc332ore.1 uc332ore.1 
ENSMUST00000266026.1 ENSMUSG00000124820 ENSMUST00000266026.1 ENSMUSG00000124820 (from geneSymbol) uc332orf.1 uc332orf.1 
ENSMUST00000266029.1 ENSMUSG00000124821 ENSMUST00000266029.1 ENSMUSG00000124821 (from geneSymbol) uc332ori.1 uc332ori.1 
ENSMUST00000266036.1 ENSMUSG00000124823 ENSMUST00000266036.1 ENSMUSG00000124823 (from geneSymbol) uc332oro.1 uc332oro.1 
ENSMUST00000266041.1 Gm56641 ENSMUST00000266041.1 Gm56641 (from geneSymbol) uc332ort.1 uc332ort.1 
ENSMUST00000266049.1 ENSMUSG00000124824 ENSMUST00000266049.1 ENSMUSG00000124824 (from geneSymbol) uc332osb.1 uc332osb.1 
ENSMUST00000266142.1 ENSMUSG00000124825 ENSMUST00000266142.1 ENSMUSG00000124825 (from geneSymbol) uc332ovq.1 uc332ovq.1 
ENSMUST00000266147.1 ENSMUSG00000124826 ENSMUST00000266147.1 ENSMUSG00000124826 (from geneSymbol) uc332ovv.1 uc332ovv.1 
ENSMUST00000266149.1 ENSMUSG00000124828 ENSMUST00000266149.1 ENSMUSG00000124828 (from geneSymbol) uc332ovw.1 uc332ovw.1 
ENSMUST00000266154.1 ENSMUSG00000124830 ENSMUST00000266154.1 ENSMUSG00000124830 (from geneSymbol) uc332ovz.1 uc332ovz.1 
ENSMUST00000266173.1 ENSMUSG00000124831 ENSMUST00000266173.1 ENSMUSG00000124831 (from geneSymbol) uc332ows.1 uc332ows.1 
ENSMUST00000266183.1 ENSMUSG00000124833 ENSMUST00000266183.1 ENSMUSG00000124833 (from geneSymbol) uc332oxa.1 uc332oxa.1 
ENSMUST00000266185.1 ENSMUSG00000124834 ENSMUST00000266185.1 ENSMUSG00000124834 (from geneSymbol) AK029445 uc332oxc.1 uc332oxc.1 
ENSMUST00000266186.1 ENSMUSG00000124835 ENSMUST00000266186.1 ENSMUSG00000124835 (from geneSymbol) uc332oxd.1 uc332oxd.1 
ENSMUST00000266190.1 ENSMUSG00000124836 ENSMUST00000266190.1 ENSMUSG00000124836 (from geneSymbol) uc332oxh.1 uc332oxh.1 
ENSMUST00000266224.1 Gm5532 ENSMUST00000266224.1 Gm5532 (from geneSymbol) AK147021 uc332oyp.1 uc332oyp.1 
ENSMUST00000266245.1 ENSMUSG00000124837 ENSMUST00000266245.1 ENSMUSG00000124837 (from geneSymbol) uc332ozk.1 uc332ozk.1 
ENSMUST00000266247.1 ENSMUSG00000124838 ENSMUST00000266247.1 ENSMUSG00000124838 (from geneSymbol) uc332ozm.1 uc332ozm.1 
ENSMUST00000266249.1 ENSMUSG00000124839 ENSMUST00000266249.1 ENSMUSG00000124839 (from geneSymbol) uc332ozo.1 uc332ozo.1 
ENSMUST00000266252.1 ENSMUSG00000124841 ENSMUST00000266252.1 ENSMUSG00000124841 (from geneSymbol) uc332ozp.1 uc332ozp.1 
ENSMUST00000266253.1 ENSMUSG00000124842 ENSMUST00000266253.1 ENSMUSG00000124842 (from geneSymbol) uc332ozq.1 uc332ozq.1 
ENSMUST00000266268.1 Gm43476 ENSMUST00000266268.1 Gm43476 (from geneSymbol) AK019750 uc332paf.1 uc332paf.1 
ENSMUST00000266298.1 ENSMUSG00000124843 ENSMUST00000266298.1 ENSMUSG00000124843 (from geneSymbol) uc332pbj.1 uc332pbj.1 
ENSMUST00000266299.1 ENSMUSG00000124844 ENSMUST00000266299.1 ENSMUSG00000124844 (from geneSymbol) uc332pbk.1 uc332pbk.1 
ENSMUST00000266300.1 ENSMUSG00000124845 ENSMUST00000266300.1 ENSMUSG00000124845 (from geneSymbol) uc332pbl.1 uc332pbl.1 
ENSMUST00000266302.1 ENSMUSG00000124846 ENSMUST00000266302.1 ENSMUSG00000124846 (from geneSymbol) uc332pbn.1 uc332pbn.1 
ENSMUST00000266308.1 Gm15241 ENSMUST00000266308.1 Gm15241 (from geneSymbol) uc332pbt.1 uc332pbt.1 
ENSMUST00000266309.1 ENSMUSG00000124847 ENSMUST00000266309.1 ENSMUSG00000124847 (from geneSymbol) uc332pbu.1 uc332pbu.1 
ENSMUST00000266311.1 ENSMUSG00000124848 ENSMUST00000266311.1 ENSMUSG00000124848 (from geneSymbol) uc332pbw.1 uc332pbw.1 
ENSMUST00000266312.1 ENSMUSG00000124849 ENSMUST00000266312.1 ENSMUSG00000124849 (from geneSymbol) uc332pbx.1 uc332pbx.1 
ENSMUST00000266317.1 ENSMUSG00000124850 ENSMUST00000266317.1 ENSMUSG00000124850 (from geneSymbol) uc332pcc.1 uc332pcc.1 
ENSMUST00000266320.1 Gm32729 ENSMUST00000266320.1 Gm32729 (from geneSymbol) uc332pcf.1 uc332pcf.1 
ENSMUST00000266327.1 ENSMUSG00000124851 ENSMUST00000266327.1 ENSMUSG00000124851 (from geneSymbol) uc332pcm.1 uc332pcm.1 
ENSMUST00000266332.1 ENSMUSG00000124852 ENSMUST00000266332.1 ENSMUSG00000124852 (from geneSymbol) uc332pcr.1 uc332pcr.1 
ENSMUST00000266338.1 ENSMUSG00000124853 ENSMUST00000266338.1 ENSMUSG00000124853 (from geneSymbol) uc332pcx.1 uc332pcx.1 
ENSMUST00000266343.1 ENSMUSG00000124854 ENSMUST00000266343.1 ENSMUSG00000124854 (from geneSymbol) uc332pdc.1 uc332pdc.1 
ENSMUST00000266348.1 ENSMUSG00000124855 ENSMUST00000266348.1 ENSMUSG00000124855 (from geneSymbol) uc332pdh.1 uc332pdh.1 
ENSMUST00000266349.1 ENSMUSG00000124856 ENSMUST00000266349.1 ENSMUSG00000124856 (from geneSymbol) uc332pdi.1 uc332pdi.1 
ENSMUST00000266350.1 ENSMUSG00000124857 ENSMUST00000266350.1 ENSMUSG00000124857 (from geneSymbol) uc332pdj.1 uc332pdj.1 
ENSMUST00000266351.1 ENSMUSG00000124858 ENSMUST00000266351.1 ENSMUSG00000124858 (from geneSymbol) uc332pdk.1 uc332pdk.1 
ENSMUST00000266353.1 ENSMUSG00000124859 ENSMUST00000266353.1 ENSMUSG00000124859 (from geneSymbol) uc332pdm.1 uc332pdm.1 
ENSMUST00000266369.1 ENSMUSG00000124860 ENSMUST00000266369.1 ENSMUSG00000124860 (from geneSymbol) uc332pec.1 uc332pec.1 
ENSMUST00000266372.1 ENSMUSG00000124861 ENSMUST00000266372.1 ENSMUSG00000124861 (from geneSymbol) uc332pee.1 uc332pee.1 
ENSMUST00000266374.1 Gm14223 ENSMUST00000266374.1 Gm14223 (from geneSymbol) uc332peg.1 uc332peg.1 
ENSMUST00000266376.1 1700028E10Rik ENSMUST00000266376.1 1700028E10Rik (from geneSymbol) AK031407 uc332pei.1 uc332pei.1 
ENSMUST00000266393.1 ENSMUSG00000124862 ENSMUST00000266393.1 ENSMUSG00000124862 (from geneSymbol) uc332pez.1 uc332pez.1 
ENSMUST00000266395.1 ENSMUSG00000124863 ENSMUST00000266395.1 ENSMUSG00000124863 (from geneSymbol) uc332pfb.1 uc332pfb.1 
ENSMUST00000266396.1 ENSMUSG00000124864 ENSMUST00000266396.1 ENSMUSG00000124864 (from geneSymbol) uc332pfc.1 uc332pfc.1 
ENSMUST00000266401.1 ENSMUSG00000124865 ENSMUST00000266401.1 ENSMUSG00000124865 (from geneSymbol) uc332pfh.1 uc332pfh.1 
ENSMUST00000266404.1 ENSMUSG00000124866 ENSMUST00000266404.1 ENSMUSG00000124866 (from geneSymbol) uc332pfk.1 uc332pfk.1 
ENSMUST00000266409.1 ENSMUSG00000124867 ENSMUST00000266409.1 ENSMUSG00000124867 (from geneSymbol) uc332pfp.1 uc332pfp.1 
ENSMUST00000266410.1 ENSMUSG00000124868 ENSMUST00000266410.1 ENSMUSG00000124868 (from geneSymbol) uc332pfq.1 uc332pfq.1 
ENSMUST00000266415.1 ENSMUSG00000124869 ENSMUST00000266415.1 ENSMUSG00000124869 (from geneSymbol) uc332pfv.1 uc332pfv.1 
ENSMUST00000266416.1 ENSMUSG00000124870 ENSMUST00000266416.1 ENSMUSG00000124870 (from geneSymbol) uc332pfw.1 uc332pfw.1 
ENSMUST00000266452.1 Gm13775 ENSMUST00000266452.1 Gm13775 (from geneSymbol) uc332phg.1 uc332phg.1 
ENSMUST00000266711.1 ENSMUSG00000124871 ENSMUST00000266711.1 ENSMUSG00000124871 (from geneSymbol) uc332prd.1 uc332prd.1 
ENSMUST00000266712.1 ENSMUSG00000124872 ENSMUST00000266712.1 ENSMUSG00000124872 (from geneSymbol) uc332pre.1 uc332pre.1 
ENSMUST00000266714.1 ENSMUSG00000124873 ENSMUST00000266714.1 ENSMUSG00000124873 (from geneSymbol) uc332prg.1 uc332prg.1 
ENSMUST00000266719.1 Gm31957 ENSMUST00000266719.1 Gm31957 (from geneSymbol) uc332prl.1 uc332prl.1 
ENSMUST00000266738.1 ENSMUSG00000124875 ENSMUST00000266738.1 ENSMUSG00000124875 (from geneSymbol) uc332pse.1 uc332pse.1 
ENSMUST00000266739.1 ENSMUSG00000124876 ENSMUST00000266739.1 ENSMUSG00000124876 (from geneSymbol) uc332psf.1 uc332psf.1 
ENSMUST00000266740.1 ENSMUSG00000124877 ENSMUST00000266740.1 ENSMUSG00000124877 (from geneSymbol) uc332psg.1 uc332psg.1 
ENSMUST00000266744.1 ENSMUSG00000124878 ENSMUST00000266744.1 ENSMUSG00000124878 (from geneSymbol) uc332psk.1 uc332psk.1 
ENSMUST00000266749.1 ENSMUSG00000124879 ENSMUST00000266749.1 ENSMUSG00000124879 (from geneSymbol) uc332psp.1 uc332psp.1 
ENSMUST00000266751.1 ENSMUSG00000124880 ENSMUST00000266751.1 ENSMUSG00000124880 (from geneSymbol) uc332psr.1 uc332psr.1 
ENSMUST00000266752.1 ENSMUSG00000124881 ENSMUST00000266752.1 ENSMUSG00000124881 (from geneSymbol) uc332pss.1 uc332pss.1 
ENSMUST00000266754.1 ENSMUSG00000124882 ENSMUST00000266754.1 ENSMUSG00000124882 (from geneSymbol) uc332psu.1 uc332psu.1 
ENSMUST00000266757.1 ENSMUSG00000124883 ENSMUST00000266757.1 ENSMUSG00000124883 (from geneSymbol) uc332psx.1 uc332psx.1 
ENSMUST00000266759.1 ENSMUSG00000124884 ENSMUST00000266759.1 ENSMUSG00000124884 (from geneSymbol) uc332psz.1 uc332psz.1 
ENSMUST00000266761.1 ENSMUSG00000124885 ENSMUST00000266761.1 ENSMUSG00000124885 (from geneSymbol) uc332ptb.1 uc332ptb.1 
ENSMUST00000266763.1 ENSMUSG00000124886 ENSMUST00000266763.1 ENSMUSG00000124886 (from geneSymbol) uc332ptd.1 uc332ptd.1 
ENSMUST00000266768.1 ENSMUSG00000124887 ENSMUST00000266768.1 ENSMUSG00000124887 (from geneSymbol) uc332pti.1 uc332pti.1 
ENSMUST00000266769.1 1700061E17Rik ENSMUST00000266769.1 1700061E17Rik (from geneSymbol) AK086953 uc332ptj.1 uc332ptj.1 
ENSMUST00000266805.1 ENSMUSG00000124888 ENSMUST00000266805.1 ENSMUSG00000124888 (from geneSymbol) uc332put.1 uc332put.1 
ENSMUST00000266809.1 ENSMUSG00000124889 ENSMUST00000266809.1 ENSMUSG00000124889 (from geneSymbol) uc332pux.1 uc332pux.1 
ENSMUST00000266811.1 ENSMUSG00000124890 ENSMUST00000266811.1 ENSMUSG00000124890 (from geneSymbol) uc332puz.1 uc332puz.1 
ENSMUST00000266817.1 ENSMUSG00000124891 ENSMUST00000266817.1 ENSMUSG00000124891 (from geneSymbol) uc332pvf.1 uc332pvf.1 
ENSMUST00000266818.1 ENSMUSG00000124892 ENSMUST00000266818.1 ENSMUSG00000124892 (from geneSymbol) uc332pvg.1 uc332pvg.1 
ENSMUST00000266820.1 ENSMUSG00000124893 ENSMUST00000266820.1 ENSMUSG00000124893 (from geneSymbol) uc332pvi.1 uc332pvi.1 
ENSMUST00000266822.1 ENSMUSG00000124894 ENSMUST00000266822.1 ENSMUSG00000124894 (from geneSymbol) uc332pvk.1 uc332pvk.1 
ENSMUST00000266823.1 ENSMUSG00000124895 ENSMUST00000266823.1 ENSMUSG00000124895 (from geneSymbol) uc332pvl.1 uc332pvl.1 
ENSMUST00000266825.1 ENSMUSG00000124896 ENSMUST00000266825.1 ENSMUSG00000124896 (from geneSymbol) uc332pvn.1 uc332pvn.1 
ENSMUST00000266826.1 ENSMUSG00000124897 ENSMUST00000266826.1 ENSMUSG00000124897 (from geneSymbol) uc332pvo.1 uc332pvo.1 
ENSMUST00000266827.1 ENSMUSG00000124898 ENSMUST00000266827.1 ENSMUSG00000124898 (from geneSymbol) uc332pvp.1 uc332pvp.1 
ENSMUST00000266838.1 ENSMUSG00000124899 ENSMUST00000266838.1 ENSMUSG00000124899 (from geneSymbol) uc332pwa.1 uc332pwa.1 
ENSMUST00000266841.1 Bcas3os1 ENSMUST00000266841.1 Bcas3os1 (from geneSymbol) AK018376 uc332pwd.1 uc332pwd.1 
ENSMUST00000266846.1 ENSMUSG00000124900 ENSMUST00000266846.1 ENSMUSG00000124900 (from geneSymbol) uc332pwi.1 uc332pwi.1 
ENSMUST00000266847.1 ENSMUSG00000124901 ENSMUST00000266847.1 ENSMUSG00000124901 (from geneSymbol) uc332pwj.1 uc332pwj.1 
ENSMUST00000266848.1 ENSMUSG00000124902 ENSMUST00000266848.1 ENSMUSG00000124902 (from geneSymbol) uc332pwk.1 uc332pwk.1 
ENSMUST00000266864.1 ENSMUSG00000124903 ENSMUST00000266864.1 ENSMUSG00000124903 (from geneSymbol) uc332pxa.1 uc332pxa.1 
ENSMUST00000266871.1 ENSMUSG00000124904 ENSMUST00000266871.1 ENSMUSG00000124904 (from geneSymbol) uc332pxh.1 uc332pxh.1 
ENSMUST00000266874.1 ENSMUSG00000124905 ENSMUST00000266874.1 predicted gene, 19897 (from RefSeq NR_040339.1) NR_040339 uc332pxk.1 uc332pxk.1 
ENSMUST00000266875.1 ENSMUSG00000124906 ENSMUST00000266875.1 ENSMUSG00000124906 (from geneSymbol) uc332pxl.1 uc332pxl.1 
ENSMUST00000266881.1 ENSMUSG00000124908 ENSMUST00000266881.1 ENSMUSG00000124908 (from geneSymbol) uc332pxq.1 uc332pxq.1 
ENSMUST00000266882.1 ENSMUSG00000124909 ENSMUST00000266882.1 ENSMUSG00000124909 (from geneSymbol) uc332pxr.1 uc332pxr.1 
ENSMUST00000266883.1 ENSMUSG00000124910 ENSMUST00000266883.1 ENSMUSG00000124910 (from geneSymbol) uc332pxs.1 uc332pxs.1 
ENSMUST00000266884.1 ENSMUSG00000124911 ENSMUST00000266884.1 ENSMUSG00000124911 (from geneSymbol) uc332pxt.1 uc332pxt.1 
ENSMUST00000266885.1 ENSMUSG00000124912 ENSMUST00000266885.1 ENSMUSG00000124912 (from geneSymbol) uc332pxu.1 uc332pxu.1 
ENSMUST00000266886.1 ENSMUSG00000124913 ENSMUST00000266886.1 ENSMUSG00000124913 (from geneSymbol) uc332pxv.1 uc332pxv.1 
ENSMUST00000266894.1 Gm29139 ENSMUST00000266894.1 Gm29139 (from geneSymbol) AK131770 uc332pyd.1 uc332pyd.1 
ENSMUST00000266899.1 ENSMUSG00000124915 ENSMUST00000266899.1 ENSMUSG00000124915 (from geneSymbol) uc332pyh.1 uc332pyh.1 
ENSMUST00000266901.1 ENSMUSG00000124916 ENSMUST00000266901.1 ENSMUSG00000124916 (from geneSymbol) uc332pyj.1 uc332pyj.1 
ENSMUST00000266903.1 ENSMUSG00000124917 ENSMUST00000266903.1 ENSMUSG00000124917 (from geneSymbol) uc332pyl.1 uc332pyl.1 
ENSMUST00000266908.1 ENSMUSG00000124918 ENSMUST00000266908.1 ENSMUSG00000124918 (from geneSymbol) uc332pyo.1 uc332pyo.1 
ENSMUST00000266911.1 ENSMUSG00000124919 ENSMUST00000266911.1 ENSMUSG00000124919 (from geneSymbol) uc332pyr.1 uc332pyr.1 
ENSMUST00000266918.1 ENSMUSG00000124920 ENSMUST00000266918.1 ENSMUSG00000124920 (from geneSymbol) uc332pyy.1 uc332pyy.1 
ENSMUST00000266927.1 ENSMUSG00000124921 ENSMUST00000266927.1 ENSMUSG00000124921 (from geneSymbol) uc332pzg.1 uc332pzg.1 
ENSMUST00000266940.1 ENSMUSG00000124922 ENSMUST00000266940.1 ENSMUSG00000124922 (from geneSymbol) uc332pzt.1 uc332pzt.1 
ENSMUST00000266942.1 ENSMUSG00000124923 ENSMUST00000266942.1 ENSMUSG00000124923 (from geneSymbol) uc332pzv.1 uc332pzv.1 
ENSMUST00000266943.1 ENSMUSG00000124924 ENSMUST00000266943.1 ENSMUSG00000124924 (from geneSymbol) uc332pzw.1 uc332pzw.1 
ENSMUST00000266944.1 ENSMUSG00000124925 ENSMUST00000266944.1 ENSMUSG00000124925 (from geneSymbol) uc332pzx.1 uc332pzx.1 
ENSMUST00000266946.1 ENSMUSG00000124926 ENSMUST00000266946.1 ENSMUSG00000124926 (from geneSymbol) uc332pzz.1 uc332pzz.1 
ENSMUST00000266947.1 ENSMUSG00000124927 ENSMUST00000266947.1 ENSMUSG00000124927 (from geneSymbol) uc332qaa.1 uc332qaa.1 
ENSMUST00000266948.1 ENSMUSG00000124928 ENSMUST00000266948.1 ENSMUSG00000124928 (from geneSymbol) uc332qab.1 uc332qab.1 
ENSMUST00000266949.1 ENSMUSG00000124929 ENSMUST00000266949.1 ENSMUSG00000124929 (from geneSymbol) uc332qac.1 uc332qac.1 
ENSMUST00000266951.1 Gm29317 ENSMUST00000266951.1 Gm29317 (from geneSymbol) uc332qae.1 uc332qae.1 
ENSMUST00000266953.1 ENSMUSG00000124932 ENSMUST00000266953.1 ENSMUSG00000124932 (from geneSymbol) uc332qaf.1 uc332qaf.1 
ENSMUST00000266955.1 ENSMUSG00000124933 ENSMUST00000266955.1 ENSMUSG00000124933 (from geneSymbol) uc332qah.1 uc332qah.1 
ENSMUST00000266957.1 ENSMUSG00000124934 ENSMUST00000266957.1 ENSMUSG00000124934 (from geneSymbol) uc332qaj.1 uc332qaj.1 
ENSMUST00000266958.1 ENSMUSG00000124935 ENSMUST00000266958.1 ENSMUSG00000124935 (from geneSymbol) uc332qak.1 uc332qak.1 
ENSMUST00000266963.1 ENSMUSG00000124936 ENSMUST00000266963.1 ENSMUSG00000124936 (from geneSymbol) uc332qap.1 uc332qap.1 
ENSMUST00000266964.1 Gm10398 ENSMUST00000266964.1 Gm10398 (from geneSymbol) AK131726 uc332qaq.1 uc332qaq.1 
ENSMUST00000266965.1 Pip5k1bos ENSMUST00000266965.1 phosphatidylinositol-4-phosphate 5-kinase, type 1 beta, opposite strand, transcript variant 2 (from RefSeq NR_167769.1) NR_167769 uc332qar.1 uc332qar.1 
ENSMUST00000266970.1 ENSMUSG00000124937 ENSMUST00000266970.1 ENSMUSG00000124937 (from geneSymbol) uc332qaw.1 uc332qaw.1 
ENSMUST00000266973.1 Bcas3os2 ENSMUST00000266973.1 Bcas3os2 (from geneSymbol) KY467601 uc332qaz.1 uc332qaz.1 
ENSMUST00000266974.1 Gm14041 ENSMUST00000266974.1 Gm14041 (from geneSymbol) uc332qba.1 uc332qba.1 
ENSMUST00000266983.1 ENSMUSG00000124938 ENSMUST00000266983.1 ENSMUSG00000124938 (from geneSymbol) BC116250 uc332qbj.1 uc332qbj.1 
ENSMUST00000266985.1 ENSMUSG00000124939 ENSMUST00000266985.1 ENSMUSG00000124939 (from geneSymbol) uc332qbl.1 uc332qbl.1 
ENSMUST00000266986.1 ENSMUSG00000124940 ENSMUST00000266986.1 ENSMUSG00000124940 (from geneSymbol) uc332qbm.1 uc332qbm.1 
ENSMUST00000266989.1 Gm20901 ENSMUST00000266989.1 Gm20901 (from geneSymbol) BC099537 uc332qbp.1 uc332qbp.1 
ENSMUST00000266991.1 ENSMUSG00000124942 ENSMUST00000266991.1 ENSMUSG00000124942 (from geneSymbol) uc332qbr.1 uc332qbr.1 
ENSMUST00000266992.1 Gm14344 ENSMUST00000266992.1 Gm14344 (from geneSymbol) uc332qbs.1 uc332qbs.1 
ENSMUST00000267000.1 ENSMUSG00000124943 ENSMUST00000267000.1 ENSMUSG00000124943 (from geneSymbol) uc332qca.1 uc332qca.1 
ENSMUST00000267007.1 ENSMUSG00000124944 ENSMUST00000267007.1 ENSMUSG00000124944 (from geneSymbol) LF196156 uc332qch.1 uc332qch.1 
ENSMUST00000267008.1 ENSMUSG00000124945 ENSMUST00000267008.1 ENSMUSG00000124945 (from geneSymbol) uc332qci.1 uc332qci.1 
ENSMUST00000267012.1 ENSMUSG00000124946 ENSMUST00000267012.1 ENSMUSG00000124946 (from geneSymbol) uc332qcl.1 uc332qcl.1 
ENSMUST00000267013.1 ENSMUSG00000124947 ENSMUST00000267013.1 ENSMUSG00000124947 (from geneSymbol) uc332qcm.1 uc332qcm.1 
ENSMUST00000267016.1 ENSMUSG00000124948 ENSMUST00000267016.1 ENSMUSG00000124948 (from geneSymbol) uc332qcp.1 uc332qcp.1 
ENSMUST00000267023.1 ENSMUSG00000124949 ENSMUST00000267023.1 ENSMUSG00000124949 (from geneSymbol) LF200322 uc332qcw.1 uc332qcw.1 
ENSMUST00000267024.1 Gm39154 ENSMUST00000267024.1 Gm39154 (from geneSymbol) uc332qcx.1 uc332qcx.1 
ENSMUST00000267037.1 ENSMUSG00000124950 ENSMUST00000267037.1 ENSMUSG00000124950 (from geneSymbol) uc332qdk.1 uc332qdk.1 
ENSMUST00000267040.1 Ino80dos ENSMUST00000267040.1 Ino80dos (from geneSymbol) AK017924 uc332qdn.1 uc332qdn.1 
ENSMUST00000267059.1 ENSMUSG00000124951 ENSMUST00000267059.1 ENSMUSG00000124951 (from geneSymbol) uc332qeg.1 uc332qeg.1 
ENSMUST00000267060.1 1700015O11Rik ENSMUST00000267060.1 1700015O11Rik (from geneSymbol) AK006003 uc332qeh.1 uc332qeh.1 
ENSMUST00000267065.1 ENSMUSG00000124952 ENSMUST00000267065.1 ENSMUSG00000124952 (from geneSymbol) uc332qem.1 uc332qem.1 
ENSMUST00000267066.1 ENSMUSG00000124953 ENSMUST00000267066.1 ENSMUSG00000124953 (from geneSymbol) uc332qen.1 uc332qen.1 
ENSMUST00000267069.1 ENSMUSG00000124954 ENSMUST00000267069.1 ENSMUSG00000124954 (from geneSymbol) uc332qeq.1 uc332qeq.1 
ENSMUST00000267078.1 ENSMUSG00000124955 ENSMUST00000267078.1 ENSMUSG00000124955 (from geneSymbol) uc332qez.1 uc332qez.1 
ENSMUST00000267084.1 ENSMUSG00000124957 ENSMUST00000267084.1 ENSMUSG00000124957 (from geneSymbol) uc332qfd.1 uc332qfd.1 
ENSMUST00000267085.1 ENSMUSG00000124958 ENSMUST00000267085.1 ENSMUSG00000124958 (from geneSymbol) uc332qfe.1 uc332qfe.1 
ENSMUST00000267086.1 ENSMUSG00000124959 ENSMUST00000267086.1 ENSMUSG00000124959 (from geneSymbol) uc332qff.1 uc332qff.1 
ENSMUST00000267087.1 ENSMUSG00000124960 ENSMUST00000267087.1 ENSMUSG00000124960 (from geneSymbol) uc332qfg.1 uc332qfg.1 
ENSMUST00000267164.1 ENSMUSG00000124961 ENSMUST00000267164.1 ENSMUSG00000124961 (from geneSymbol) uc332qif.1 uc332qif.1 
ENSMUST00000267343.1 ENSMUSG00000124962 ENSMUST00000267343.1 ENSMUSG00000124962 (from geneSymbol) uc332qpb.1 uc332qpb.1 
ENSMUST00000267344.1 ENSMUSG00000124963 ENSMUST00000267344.1 ENSMUSG00000124963 (from geneSymbol) uc332qpc.1 uc332qpc.1 
ENSMUST00000267346.1 ENSMUSG00000124964 ENSMUST00000267346.1 ENSMUSG00000124964 (from geneSymbol) uc332qpe.1 uc332qpe.1 
ENSMUST00000267347.1 ENSMUSG00000124965 ENSMUST00000267347.1 ENSMUSG00000124965 (from geneSymbol) uc332qpf.1 uc332qpf.1 
ENSMUST00000267349.1 Gm37267 ENSMUST00000267349.1 Gm37267 (from geneSymbol) uc332qph.1 uc332qph.1 
ENSMUST00000267353.1 ENSMUSG00000124966 ENSMUST00000267353.1 ENSMUSG00000124966 (from geneSymbol) uc332qpl.1 uc332qpl.1 
ENSMUST00000267356.1 ENSMUSG00000124967 ENSMUST00000267356.1 ENSMUSG00000124967 (from geneSymbol) uc332qpo.1 uc332qpo.1 
ENSMUST00000267357.1 Gm2824 ENSMUST00000267357.1 Gm2824 (from geneSymbol) AK083927 uc332qpp.1 uc332qpp.1 
ENSMUST00000267375.1 ENSMUSG00000124968 ENSMUST00000267375.1 ENSMUSG00000124968 (from geneSymbol) DQ713844 uc332qqh.1 uc332qqh.1 
ENSMUST00000267376.1 ENSMUSG00000124969 ENSMUST00000267376.1 ENSMUSG00000124969 (from geneSymbol) uc332qqi.1 uc332qqi.1 
ENSMUST00000267377.1 1700065J18Rik ENSMUST00000267377.1 1700065J18Rik (from geneSymbol) AK006895 uc332qqj.1 uc332qqj.1 
ENSMUST00000267390.1 ENSMUSG00000124970 ENSMUST00000267390.1 ENSMUSG00000124970 (from geneSymbol) uc332qqw.1 uc332qqw.1 
ENSMUST00000267395.1 ENSMUSG00000124971 ENSMUST00000267395.1 ENSMUSG00000124971 (from geneSymbol) uc332qrb.1 uc332qrb.1 
ENSMUST00000267397.1 ENSMUSG00000124972 ENSMUST00000267397.1 ENSMUSG00000124972 (from geneSymbol) uc332qrd.1 uc332qrd.1 
ENSMUST00000267400.1 ENSMUSG00000124973 ENSMUST00000267400.1 ENSMUSG00000124973 (from geneSymbol) uc332qrg.1 uc332qrg.1 
ENSMUST00000267406.1 ENSMUSG00000124974 ENSMUST00000267406.1 ENSMUSG00000124974 (from geneSymbol) uc332qrm.1 uc332qrm.1 
ENSMUST00000267407.1 ENSMUSG00000124975 ENSMUST00000267407.1 ENSMUSG00000124975 (from geneSymbol) uc332qrn.1 uc332qrn.1 
ENSMUST00000267410.1 ENSMUSG00000124976 ENSMUST00000267410.1 ENSMUSG00000124976 (from geneSymbol) uc332qrq.1 uc332qrq.1 
ENSMUST00000267416.1 Gm34507 ENSMUST00000267416.1 Gm34507 (from geneSymbol) uc332qrw.1 uc332qrw.1 
ENSMUST00000267430.1 ENSMUSG00000124978 ENSMUST00000267430.1 ENSMUSG00000124978 (from geneSymbol) uc332qsk.1 uc332qsk.1 
ENSMUST00000267451.1 Gm37350 ENSMUST00000267451.1 Gm37350 (from geneSymbol) uc332qtf.1 uc332qtf.1 
ENSMUST00000267452.1 ENSMUSG00000124979 ENSMUST00000267452.1 ENSMUSG00000124979 (from geneSymbol) uc332qtg.1 uc332qtg.1 
ENSMUST00000267453.1 ENSMUSG00000124980 ENSMUST00000267453.1 ENSMUSG00000124980 (from geneSymbol) uc332qth.1 uc332qth.1 
ENSMUST00000267457.1 ENSMUSG00000124981 ENSMUST00000267457.1 ENSMUSG00000124981 (from geneSymbol) AK042277 uc332qtl.1 uc332qtl.1 
ENSMUST00000267461.1 ENSMUSG00000124982 ENSMUST00000267461.1 ENSMUSG00000124982 (from geneSymbol) uc332qtp.1 uc332qtp.1 
ENSMUST00000267462.1 ENSMUSG00000124983 ENSMUST00000267462.1 ENSMUSG00000124983 (from geneSymbol) uc332qtq.1 uc332qtq.1 
ENSMUST00000267499.1 ENSMUSG00000124984 ENSMUST00000267499.1 ENSMUSG00000124984 (from geneSymbol) uc332qvb.1 uc332qvb.1 
ENSMUST00000267504.1 ENSMUSG00000124985 ENSMUST00000267504.1 ENSMUSG00000124985 (from geneSymbol) uc332qvg.1 uc332qvg.1 
ENSMUST00000267509.1 ENSMUSG00000124986 ENSMUST00000267509.1 ENSMUSG00000124986 (from geneSymbol) uc332qvl.1 uc332qvl.1 
ENSMUST00000267510.1 ENSMUSG00000124987 ENSMUST00000267510.1 ENSMUSG00000124987 (from geneSymbol) uc332qvm.1 uc332qvm.1 
ENSMUST00000267513.1 ENSMUSG00000124988 ENSMUST00000267513.1 ENSMUSG00000124988 (from geneSymbol) uc332qvp.1 uc332qvp.1 
ENSMUST00000267514.1 AI506816 ENSMUST00000267514.1 AI506816 (from geneSymbol) AK089743 uc332qvq.1 uc332qvq.1 
ENSMUST00000267518.1 ENSMUSG00000124989 ENSMUST00000267518.1 ENSMUSG00000124989 (from geneSymbol) uc332qvu.1 uc332qvu.1 
ENSMUST00000267520.1 ENSMUSG00000124990 ENSMUST00000267520.1 ENSMUSG00000124990 (from geneSymbol) uc332qvw.1 uc332qvw.1 
ENSMUST00000267521.1 Gm54095 ENSMUST00000267521.1 Gm54095 (from geneSymbol) uc332qvx.1 uc332qvx.1 
ENSMUST00000267544.1 ENSMUSG00000124991 ENSMUST00000267544.1 ENSMUSG00000124991 (from geneSymbol) uc332qws.1 uc332qws.1 
ENSMUST00000267545.1 Gm9951 ENSMUST00000267545.1 Gm9951 (from geneSymbol) AK040144 uc332qwt.1 uc332qwt.1 
ENSMUST00000267562.1 ENSMUSG00000124992 ENSMUST00000267562.1 ENSMUSG00000124992 (from geneSymbol) uc332qxk.1 uc332qxk.1 
ENSMUST00000267563.1 ENSMUSG00000124993 ENSMUST00000267563.1 ENSMUSG00000124993 (from geneSymbol) uc332qxl.1 uc332qxl.1 
ENSMUST00000267564.1 Gm20052 ENSMUST00000267564.1 Gm20052 (from geneSymbol) AK041974 uc332qxm.1 uc332qxm.1 
ENSMUST00000267574.1 ENSMUSG00000124994 ENSMUST00000267574.1 ENSMUSG00000124994 (from geneSymbol) uc332qxw.1 uc332qxw.1 
ENSMUST00000267576.1 ENSMUSG00000124995 ENSMUST00000267576.1 ENSMUSG00000124995 (from geneSymbol) uc332qxy.1 uc332qxy.1 
ENSMUST00000267578.1 Gm41183 ENSMUST00000267578.1 Gm41183 (from geneSymbol) AK075677 uc332qya.1 uc332qya.1 
ENSMUST00000267585.1 ENSMUSG00000124996 ENSMUST00000267585.1 ENSMUSG00000124996 (from geneSymbol) AK140358 uc332qyh.1 uc332qyh.1 
ENSMUST00000267586.1 ENSMUSG00000124997 ENSMUST00000267586.1 predicted gene, 41640 (from RefSeq NR_166901.1) NR_166901 uc332qyi.1 uc332qyi.1 
ENSMUST00000267604.1 ENSMUSG00000124998 ENSMUST00000267604.1 ENSMUSG00000124998 (from geneSymbol) uc332qza.1 uc332qza.1 
ENSMUST00000267609.1 ENSMUSG00000124999 ENSMUST00000267609.1 ENSMUSG00000124999 (from geneSymbol) uc332qzf.1 uc332qzf.1 
ENSMUST00000267610.1 ENSMUSG00000125000 ENSMUST00000267610.1 ENSMUSG00000125000 (from geneSymbol) uc332qzg.1 uc332qzg.1 
ENSMUST00000267616.1 ENSMUSG00000125001 ENSMUST00000267616.1 ENSMUSG00000125001 (from geneSymbol) uc332qzm.1 uc332qzm.1 
ENSMUST00000267617.1 ENSMUSG00000125002 ENSMUST00000267617.1 ENSMUSG00000125002 (from geneSymbol) uc332qzn.1 uc332qzn.1 
ENSMUST00000267618.1 ENSMUSG00000125003 ENSMUST00000267618.1 ENSMUSG00000125003 (from geneSymbol) uc332qzo.1 uc332qzo.1 
ENSMUST00000267619.1 ENSMUSG00000125004 ENSMUST00000267619.1 ENSMUSG00000125004 (from geneSymbol) uc332qzp.1 uc332qzp.1 
ENSMUST00000267620.1 ENSMUSG00000125005 ENSMUST00000267620.1 ENSMUSG00000125005 (from geneSymbol) uc332qzq.1 uc332qzq.1 
ENSMUST00000267624.1 ENSMUSG00000125006 ENSMUST00000267624.1 ENSMUSG00000125006 (from geneSymbol) uc332qzu.1 uc332qzu.1 
ENSMUST00000267625.1 ENSMUSG00000125007 ENSMUST00000267625.1 ENSMUSG00000125007 (from geneSymbol) LF203046 uc332qzv.1 uc332qzv.1 
ENSMUST00000267627.1 Gm50341 ENSMUST00000267627.1 Gm50341 (from geneSymbol) uc332qzx.1 uc332qzx.1 
ENSMUST00000267631.1 ENSMUSG00000125008 ENSMUST00000267631.1 ENSMUSG00000125008 (from geneSymbol) uc332rab.1 uc332rab.1 
ENSMUST00000267633.1 ENSMUSG00000125009 ENSMUST00000267633.1 ENSMUSG00000125009 (from geneSymbol) uc332rad.1 uc332rad.1 
ENSMUST00000267635.1 ENSMUSG00000125010 ENSMUST00000267635.1 ENSMUSG00000125010 (from geneSymbol) uc332rae.1 uc332rae.1 
ENSMUST00000267639.1 1700105P06Rik ENSMUST00000267639.1 1700105P06Rik (from geneSymbol) uc332rag.1 uc332rag.1 
ENSMUST00000267645.1 ENSMUSG00000125011 ENSMUST00000267645.1 ENSMUSG00000125011 (from geneSymbol) uc332ram.1 uc332ram.1 
ENSMUST00000267646.1 ENSMUSG00000125012 ENSMUST00000267646.1 ENSMUSG00000125012 (from geneSymbol) uc332ran.1 uc332ran.1 
ENSMUST00000267648.1 ENSMUSG00000125013 ENSMUST00000267648.1 ENSMUSG00000125013 (from geneSymbol) uc332rap.1 uc332rap.1 
ENSMUST00000267650.1 Gm27032 ENSMUST00000267650.1 Gm27032 (from geneSymbol) uc332rar.1 uc332rar.1 
ENSMUST00000267654.1 ENSMUSG00000125014 ENSMUST00000267654.1 ENSMUSG00000125014 (from geneSymbol) uc332rav.1 uc332rav.1 
ENSMUST00000267655.1 ENSMUSG00000125015 ENSMUST00000267655.1 ENSMUSG00000125015 (from geneSymbol) uc332raw.1 uc332raw.1 
ENSMUST00000267656.1 ENSMUSG00000125016 ENSMUST00000267656.1 ENSMUSG00000125016 (from geneSymbol) uc332rax.1 uc332rax.1 
ENSMUST00000267657.1 ENSMUSG00000125017 ENSMUST00000267657.1 ENSMUSG00000125017 (from geneSymbol) uc332ray.1 uc332ray.1 
ENSMUST00000267658.1 ENSMUSG00000125018 ENSMUST00000267658.1 ENSMUSG00000125018 (from geneSymbol) uc332raz.1 uc332raz.1 
ENSMUST00000267659.1 ENSMUSG00000125019 ENSMUST00000267659.1 ENSMUSG00000125019 (from geneSymbol) uc332rba.1 uc332rba.1 
ENSMUST00000267665.1 Gm13056 ENSMUST00000267665.1 Gm13056 (from geneSymbol) uc332rbg.1 uc332rbg.1 
ENSMUST00000267668.1 ENSMUSG00000125020 ENSMUST00000267668.1 ENSMUSG00000125020 (from geneSymbol) uc332rbj.1 uc332rbj.1 
ENSMUST00000267670.1 ENSMUSG00000125021 ENSMUST00000267670.1 ENSMUSG00000125021 (from geneSymbol) uc332rbl.1 uc332rbl.1 
ENSMUST00000267673.1 ENSMUSG00000125022 ENSMUST00000267673.1 ENSMUSG00000125022 (from geneSymbol) uc332rbo.1 uc332rbo.1 
ENSMUST00000267675.1 ENSMUSG00000125023 ENSMUST00000267675.1 ENSMUSG00000125023 (from geneSymbol) uc332rbq.1 uc332rbq.1 
ENSMUST00000267676.1 ENSMUSG00000125024 ENSMUST00000267676.1 ENSMUSG00000125024 (from geneSymbol) uc332rbr.1 uc332rbr.1 
ENSMUST00000267678.1 ENSMUSG00000125025 ENSMUST00000267678.1 ENSMUSG00000125025 (from geneSymbol) uc332rbt.1 uc332rbt.1 
ENSMUST00000267679.1 Gm20684 ENSMUST00000267679.1 Gm20684 (from geneSymbol) uc332rbu.1 uc332rbu.1 
ENSMUST00000267695.1 Gm11732 ENSMUST00000267695.1 Gm11732 (from geneSymbol) AK045779 uc332rck.1 uc332rck.1 
ENSMUST00000267703.1 ENSMUSG00000125026 ENSMUST00000267703.1 ENSMUSG00000125026 (from geneSymbol) uc332rcs.1 uc332rcs.1 
ENSMUST00000267704.1 ENSMUSG00000125027 ENSMUST00000267704.1 ENSMUSG00000125027 (from geneSymbol) uc332rct.1 uc332rct.1 
ENSMUST00000267705.1 ENSMUSG00000125028 ENSMUST00000267705.1 ENSMUSG00000125028 (from geneSymbol) uc332rcu.1 uc332rcu.1 
ENSMUST00000267706.1 ENSMUSG00000125029 ENSMUST00000267706.1 ENSMUSG00000125029 (from geneSymbol) uc332rcv.1 uc332rcv.1 
ENSMUST00000267707.1 ENSMUSG00000125030 ENSMUST00000267707.1 ENSMUSG00000125030 (from geneSymbol) uc332rcw.1 uc332rcw.1 
ENSMUST00000267709.1 ENSMUSG00000125031 ENSMUST00000267709.1 ENSMUSG00000125031 (from geneSymbol) uc332rcy.1 uc332rcy.1 
ENSMUST00000267710.1 Gm41291 ENSMUST00000267710.1 Gm41291 (from geneSymbol) uc332rcz.1 uc332rcz.1 
ENSMUST00000267714.1 ENSMUSG00000125032 ENSMUST00000267714.1 ENSMUSG00000125032 (from geneSymbol) uc332rdd.1 uc332rdd.1 
ENSMUST00000267715.1 ENSMUSG00000125033 ENSMUST00000267715.1 ENSMUSG00000125033 (from geneSymbol) uc332rde.1 uc332rde.1 
ENSMUST00000267716.1 ENSMUSG00000125034 ENSMUST00000267716.1 ENSMUSG00000125034 (from geneSymbol) uc332rdf.1 uc332rdf.1 
ENSMUST00000267717.1 ENSMUSG00000125035 ENSMUST00000267717.1 ENSMUSG00000125035 (from geneSymbol) uc332rdg.1 uc332rdg.1 
ENSMUST00000267719.1 ENSMUSG00000125036 ENSMUST00000267719.1 ENSMUSG00000125036 (from geneSymbol) uc332rdi.1 uc332rdi.1 
ENSMUST00000267720.1 ENSMUSG00000125037 ENSMUST00000267720.1 ENSMUSG00000125037 (from geneSymbol) uc332rdj.1 uc332rdj.1 
ENSMUST00000267748.1 ENSMUSG00000125038 ENSMUST00000267748.1 ENSMUSG00000125038 (from geneSymbol) uc332rel.1 uc332rel.1 
ENSMUST00000267752.1 ENSMUSG00000125039 ENSMUST00000267752.1 ENSMUSG00000125039 (from geneSymbol) uc332rep.1 uc332rep.1 
ENSMUST00000267755.1 ENSMUSG00000125040 ENSMUST00000267755.1 ENSMUSG00000125040 (from geneSymbol) uc332res.1 uc332res.1 
ENSMUST00000267761.1 ENSMUSG00000125041 ENSMUST00000267761.1 ENSMUSG00000125041 (from geneSymbol) uc332rey.1 uc332rey.1 
ENSMUST00000267763.1 ENSMUSG00000125042 ENSMUST00000267763.1 ENSMUSG00000125042 (from geneSymbol) uc332rfa.1 uc332rfa.1 
ENSMUST00000267766.1 ENSMUSG00000125043 ENSMUST00000267766.1 ENSMUSG00000125043 (from geneSymbol) uc332rfd.1 uc332rfd.1 
ENSMUST00000267768.1 ENSMUSG00000125045 ENSMUST00000267768.1 ENSMUSG00000125045 (from geneSymbol) uc332rfe.1 uc332rfe.1 
ENSMUST00000267769.1 Gm12909 ENSMUST00000267769.1 Gm12909 (from geneSymbol) uc332rff.1 uc332rff.1 
ENSMUST00000267783.1 ENSMUSG00000125046 ENSMUST00000267783.1 ENSMUSG00000125046 (from geneSymbol) uc332rft.1 uc332rft.1 
ENSMUST00000267785.1 ENSMUSG00000125047 ENSMUST00000267785.1 ENSMUSG00000125047 (from geneSymbol) uc332rfv.1 uc332rfv.1 
ENSMUST00000267799.1 Gm47051 ENSMUST00000267799.1 Gm47051 (from geneSymbol) uc332rgj.1 uc332rgj.1 
ENSMUST00000267802.1 ENSMUSG00000125048 ENSMUST00000267802.1 ENSMUSG00000125048 (from geneSymbol) uc332rgm.1 uc332rgm.1 
ENSMUST00000267803.1 ENSMUSG00000125049 ENSMUST00000267803.1 ENSMUSG00000125049 (from geneSymbol) uc332rgn.1 uc332rgn.1 
ENSMUST00000267804.1 ENSMUSG00000125050 ENSMUST00000267804.1 ENSMUSG00000125050 (from geneSymbol) uc332rgo.1 uc332rgo.1 
ENSMUST00000267807.1 ENSMUSG00000125051 ENSMUST00000267807.1 ENSMUSG00000125051 (from geneSymbol) uc332rgr.1 uc332rgr.1 
ENSMUST00000267808.1 ENSMUSG00000125052 ENSMUST00000267808.1 ENSMUSG00000125052 (from geneSymbol) uc332rgs.1 uc332rgs.1 
ENSMUST00000267813.1 ENSMUSG00000125053 ENSMUST00000267813.1 ENSMUSG00000125053 (from geneSymbol) AK086439 uc332rgx.1 uc332rgx.1 
ENSMUST00000267836.1 ENSMUSG00000125054 ENSMUST00000267836.1 ENSMUSG00000125054 (from geneSymbol) uc332rhu.1 uc332rhu.1 
ENSMUST00000267837.1 ENSMUSG00000125055 ENSMUST00000267837.1 ENSMUSG00000125055 (from geneSymbol) uc332rhv.1 uc332rhv.1 
ENSMUST00000267838.1 ENSMUSG00000125056 ENSMUST00000267838.1 ENSMUSG00000125056 (from geneSymbol) LF203218 uc332rhw.1 uc332rhw.1 
ENSMUST00000267839.1 ENSMUSG00000125057 ENSMUST00000267839.1 ENSMUSG00000125057 (from geneSymbol) uc332rhx.1 uc332rhx.1 
ENSMUST00000267841.1 ENSMUSG00000125058 ENSMUST00000267841.1 ENSMUSG00000125058 (from geneSymbol) uc332rhz.1 uc332rhz.1 
ENSMUST00000267845.1 ENSMUSG00000125059 ENSMUST00000267845.1 ENSMUSG00000125059 (from geneSymbol) uc332rid.1 uc332rid.1 
ENSMUST00000267848.1 ENSMUSG00000125060 ENSMUST00000267848.1 ENSMUSG00000125060 (from geneSymbol) uc332rig.1 uc332rig.1 
ENSMUST00000267850.1 ENSMUSG00000125061 ENSMUST00000267850.1 ENSMUSG00000125061 (from geneSymbol) uc332rii.1 uc332rii.1 
ENSMUST00000267851.1 ENSMUSG00000125062 ENSMUST00000267851.1 ENSMUSG00000125062 (from geneSymbol) uc332rij.1 uc332rij.1 
ENSMUST00000267855.1 ENSMUSG00000125063 ENSMUST00000267855.1 ENSMUSG00000125063 (from geneSymbol) uc332rin.1 uc332rin.1 
ENSMUST00000267862.1 ENSMUSG00000125064 ENSMUST00000267862.1 ENSMUSG00000125064 (from geneSymbol) uc332riu.1 uc332riu.1 
ENSMUST00000267868.1 ENSMUSG00000125065 ENSMUST00000267868.1 ENSMUSG00000125065 (from geneSymbol) uc332rja.1 uc332rja.1 
ENSMUST00000267869.1 ENSMUSG00000125066 ENSMUST00000267869.1 ENSMUSG00000125066 (from geneSymbol) uc332rjb.1 uc332rjb.1 
ENSMUST00000267871.1 ENSMUSG00000125067 ENSMUST00000267871.1 ENSMUSG00000125067 (from geneSymbol) uc332rjd.1 uc332rjd.1 
ENSMUST00000267873.1 ENSMUSG00000125068 ENSMUST00000267873.1 ENSMUSG00000125068 (from geneSymbol) uc332rjf.1 uc332rjf.1 
ENSMUST00000267874.1 ENSMUSG00000125069 ENSMUST00000267874.1 ENSMUSG00000125069 (from geneSymbol) uc332rjg.1 uc332rjg.1 
ENSMUST00000267875.1 ENSMUSG00000125070 ENSMUST00000267875.1 ENSMUSG00000125070 (from geneSymbol) uc332rjh.1 uc332rjh.1 
ENSMUST00000267876.1 ENSMUSG00000125071 ENSMUST00000267876.1 ENSMUSG00000125071 (from geneSymbol) uc332rji.1 uc332rji.1 
ENSMUST00000267877.1 ENSMUSG00000125072 ENSMUST00000267877.1 ENSMUSG00000125072 (from geneSymbol) uc332rjj.1 uc332rjj.1 
ENSMUST00000267880.1 Gm34418 ENSMUST00000267880.1 Gm34418 (from geneSymbol) uc332rjm.1 uc332rjm.1 
ENSMUST00000267890.1 ENSMUSG00000125073 ENSMUST00000267890.1 ENSMUSG00000125073 (from geneSymbol) uc332rjw.1 uc332rjw.1 
ENSMUST00000267893.1 ENSMUSG00000125074 ENSMUST00000267893.1 ENSMUSG00000125074 (from geneSymbol) uc332rjz.1 uc332rjz.1 
ENSMUST00000267898.1 ENSMUSG00000125075 ENSMUST00000267898.1 ENSMUSG00000125075 (from geneSymbol) uc332rke.1 uc332rke.1 
ENSMUST00000267900.1 ENSMUSG00000121770 ENSMUST00000267900.1 ENSMUSG00000121770 (from geneSymbol) AK015841 uc332rkg.1 uc332rkg.1 
ENSMUST00000267905.1 ENSMUSG00000125078 ENSMUST00000267905.1 ENSMUSG00000125078 (from geneSymbol) uc332rkj.1 uc332rkj.1 
ENSMUST00000267908.1 ENSMUSG00000125079 ENSMUST00000267908.1 ENSMUSG00000125079 (from geneSymbol) uc332rkm.1 uc332rkm.1 
ENSMUST00000267910.1 ENSMUSG00000125080 ENSMUST00000267910.1 ENSMUSG00000125080 (from geneSymbol) uc332rko.1 uc332rko.1 
ENSMUST00000267912.1 ENSMUSG00000125081 ENSMUST00000267912.1 ENSMUSG00000125081 (from geneSymbol) uc332rkq.1 uc332rkq.1 
ENSMUST00000267913.1 ENSMUSG00000125082 ENSMUST00000267913.1 ENSMUSG00000125082 (from geneSymbol) uc332rkr.1 uc332rkr.1 
ENSMUST00000267917.1 ENSMUSG00000125083 ENSMUST00000267917.1 ENSMUSG00000125083 (from geneSymbol) uc332rkv.1 uc332rkv.1 
ENSMUST00000267920.1 ENSMUSG00000125084 ENSMUST00000267920.1 ENSMUSG00000125084 (from geneSymbol) uc332rky.1 uc332rky.1 
ENSMUST00000267921.1 ENSMUSG00000125085 ENSMUST00000267921.1 ENSMUSG00000125085 (from geneSymbol) uc332rkz.1 uc332rkz.1 
ENSMUST00000267926.1 ENSMUSG00000125086 ENSMUST00000267926.1 ENSMUSG00000125086 (from geneSymbol) uc332rle.1 uc332rle.1 
ENSMUST00000267928.1 ENSMUSG00000125087 ENSMUST00000267928.1 ENSMUSG00000125087 (from geneSymbol) uc332rlg.1 uc332rlg.1 
ENSMUST00000267933.1 ENSMUSG00000125088 ENSMUST00000267933.1 ENSMUSG00000125088 (from geneSymbol) AF051348 uc332rlj.1 uc332rlj.1 
ENSMUST00000267935.1 ENSMUSG00000125089 ENSMUST00000267935.1 ENSMUSG00000125089 (from geneSymbol) uc332rll.1 uc332rll.1 
ENSMUST00000267936.1 ENSMUSG00000125090 ENSMUST00000267936.1 ENSMUSG00000125090 (from geneSymbol) uc332rlm.1 uc332rlm.1 
ENSMUST00000267937.1 ENSMUSG00000125091 ENSMUST00000267937.1 ENSMUSG00000125091 (from geneSymbol) uc332rln.1 uc332rln.1 
ENSMUST00000267938.1 ENSMUSG00000125092 ENSMUST00000267938.1 ENSMUSG00000125092 (from geneSymbol) uc332rlo.1 uc332rlo.1 
ENSMUST00000267940.1 ENSMUSG00000125093 ENSMUST00000267940.1 ENSMUSG00000125093 (from geneSymbol) uc332rlq.1 uc332rlq.1 
ENSMUST00000267950.1 4930568E12Rik ENSMUST00000267950.1 4930568E12Rik (from geneSymbol) AK019792 uc332rma.1 uc332rma.1 
ENSMUST00000267970.1 ENSMUSG00000125094 ENSMUST00000267970.1 ENSMUSG00000125094 (from geneSymbol) uc332rmu.1 uc332rmu.1 
ENSMUST00000267972.1 Gm48614 ENSMUST00000267972.1 Gm48614 (from geneSymbol) uc332rmw.1 uc332rmw.1 
ENSMUST00000267976.1 ENSMUSG00000125095 ENSMUST00000267976.1 ENSMUSG00000125095 (from geneSymbol) uc332rna.1 uc332rna.1 
ENSMUST00000267979.1 Gm32865 ENSMUST00000267979.1 Gm32865 (from geneSymbol) AK016163 uc332rnd.1 uc332rnd.1 
ENSMUST00000267991.1 ENSMUSG00000125097 ENSMUST00000267991.1 ENSMUSG00000125097 (from geneSymbol) uc332rno.1 uc332rno.1 
ENSMUST00000267992.1 ENSMUSG00000125098 ENSMUST00000267992.1 ENSMUSG00000125098 (from geneSymbol) uc332rnp.1 uc332rnp.1 
ENSMUST00000267994.1 ENSMUSG00000125099 ENSMUST00000267994.1 ENSMUSG00000125099 (from geneSymbol) uc332rnr.1 uc332rnr.1 
ENSMUST00000267997.1 ENSMUSG00000125100 ENSMUST00000267997.1 ENSMUSG00000125100 (from geneSymbol) uc332rnu.1 uc332rnu.1 
ENSMUST00000267999.1 ENSMUSG00000125101 ENSMUST00000267999.1 ENSMUSG00000125101 (from geneSymbol) uc332rnw.1 uc332rnw.1 
ENSMUST00000268001.1 ENSMUSG00000125102 ENSMUST00000268001.1 ENSMUSG00000125102 (from geneSymbol) uc332rny.1 uc332rny.1 
ENSMUST00000268006.1 ENSMUSG00000125103 ENSMUST00000268006.1 ENSMUSG00000125103 (from geneSymbol) uc332rod.1 uc332rod.1 
ENSMUST00000268007.1 ENSMUSG00000125104 ENSMUST00000268007.1 ENSMUSG00000125104 (from geneSymbol) uc332roe.1 uc332roe.1 
ENSMUST00000268009.1 ENSMUSG00000125105 ENSMUST00000268009.1 ENSMUSG00000125105 (from geneSymbol) uc332rog.1 uc332rog.1 
ENSMUST00000268011.1 Gm15890 ENSMUST00000268011.1 Gm15890 (from geneSymbol) KY468202 uc332roi.1 uc332roi.1 
ENSMUST00000268027.1 ENSMUSG00000125106 ENSMUST00000268027.1 ENSMUSG00000125106 (from geneSymbol) uc332roy.1 uc332roy.1 
ENSMUST00000268049.1 ENSMUSG00000125107 ENSMUST00000268049.1 ENSMUSG00000125107 (from geneSymbol) uc332rpu.1 uc332rpu.1 
ENSMUST00000268053.1 Gm43470 ENSMUST00000268053.1 Gm43470 (from geneSymbol) uc332rpy.1 uc332rpy.1 
ENSMUST00000268066.1 Gm48051 ENSMUST00000268066.1 Gm48051 (from geneSymbol) uc332rqj.1 uc332rqj.1 
ENSMUST00000268071.1 ENSMUSG00000125109 ENSMUST00000268071.1 ENSMUSG00000125109 (from geneSymbol) uc332rqo.1 uc332rqo.1 
ENSMUST00000268072.1 ENSMUSG00000125110 ENSMUST00000268072.1 ENSMUSG00000125110 (from geneSymbol) uc332rqp.1 uc332rqp.1 
ENSMUST00000268074.1 Gm16004 ENSMUST00000268074.1 Gm16004 (from geneSymbol) uc332rqr.1 uc332rqr.1 
ENSMUST00000268078.1 ENSMUSG00000125111 ENSMUST00000268078.1 ENSMUSG00000125111 (from geneSymbol) uc332rqv.1 uc332rqv.1 
ENSMUST00000268080.1 ENSMUSG00000125112 ENSMUST00000268080.1 ENSMUSG00000125112 (from geneSymbol) uc332rqx.1 uc332rqx.1 
ENSMUST00000268081.1 ENSMUSG00000125113 ENSMUST00000268081.1 ENSMUSG00000125113 (from geneSymbol) uc332rqy.1 uc332rqy.1 
ENSMUST00000268084.1 ENSMUSG00000125114 ENSMUST00000268084.1 ENSMUSG00000125114 (from geneSymbol) uc332rrb.1 uc332rrb.1 
ENSMUST00000268085.1 ENSMUSG00000125115 ENSMUST00000268085.1 ENSMUSG00000125115 (from geneSymbol) uc332rrc.1 uc332rrc.1 
ENSMUST00000268088.1 ENSMUSG00000125116 ENSMUST00000268088.1 ENSMUSG00000125116 (from geneSymbol) LF193493 uc332rrf.1 uc332rrf.1 
ENSMUST00000268090.1 ENSMUSG00000125117 ENSMUST00000268090.1 ENSMUSG00000125117 (from geneSymbol) uc332rrh.1 uc332rrh.1 
ENSMUST00000268093.1 ENSMUSG00000125118 ENSMUST00000268093.1 ENSMUSG00000125118 (from geneSymbol) uc332rrk.1 uc332rrk.1 
ENSMUST00000268094.1 ENSMUSG00000125119 ENSMUST00000268094.1 ENSMUSG00000125119 (from geneSymbol) uc332rrl.1 uc332rrl.1 
ENSMUST00000268107.1 ENSMUSG00000125120 ENSMUST00000268107.1 ENSMUSG00000125120 (from geneSymbol) uc332rry.1 uc332rry.1 
ENSMUST00000268115.1 ENSMUSG00000125121 ENSMUST00000268115.1 ENSMUSG00000125121 (from geneSymbol) uc332rsg.1 uc332rsg.1 
ENSMUST00000268116.1 ENSMUSG00000125122 ENSMUST00000268116.1 ENSMUSG00000125122 (from geneSymbol) uc332rsh.1 uc332rsh.1 
ENSMUST00000268123.1 ENSMUSG00000125123 ENSMUST00000268123.1 ENSMUSG00000125123 (from geneSymbol) uc332rso.1 uc332rso.1 
ENSMUST00000268124.1 ENSMUSG00000125124 ENSMUST00000268124.1 ENSMUSG00000125124 (from geneSymbol) uc332rsp.1 uc332rsp.1 
ENSMUST00000268129.1 ENSMUSG00000125125 ENSMUST00000268129.1 ENSMUSG00000125125 (from geneSymbol) uc332rsu.1 uc332rsu.1 
ENSMUST00000268153.1 ENSMUSG00000125126 ENSMUST00000268153.1 ENSMUSG00000125126 (from geneSymbol) uc332rts.1 uc332rts.1 
ENSMUST00000268157.1 1700108N11Rik ENSMUST00000268157.1 1700108N11Rik (from geneSymbol) uc332rtw.1 uc332rtw.1 
ENSMUST00000268158.1 ENSMUSG00000125127 ENSMUST00000268158.1 ENSMUSG00000125127 (from geneSymbol) uc332rtx.1 uc332rtx.1 
ENSMUST00000268159.1 ENSMUSG00000125128 ENSMUST00000268159.1 ENSMUSG00000125128 (from geneSymbol) uc332rty.1 uc332rty.1 
ENSMUST00000268160.1 Gm15511 ENSMUST00000268160.1 Gm15511 (from geneSymbol) uc332rtz.1 uc332rtz.1 
ENSMUST00000268171.1 ENSMUSG00000125129 ENSMUST00000268171.1 ENSMUSG00000125129 (from geneSymbol) uc332ruk.1 uc332ruk.1 
ENSMUST00000268172.1 ENSMUSG00000125130 ENSMUST00000268172.1 ENSMUSG00000125130 (from geneSymbol) uc332rul.1 uc332rul.1 
ENSMUST00000268179.1 4933412O06Rik ENSMUST00000268179.1 4933412O06Rik (from geneSymbol) AK016796 uc332rus.1 uc332rus.1 
ENSMUST00000268206.1 ENSMUSG00000125131 ENSMUST00000268206.1 ENSMUSG00000125131 (from geneSymbol) uc332rvt.1 uc332rvt.1 
ENSMUST00000268208.1 ENSMUSG00000125132 ENSMUST00000268208.1 ENSMUSG00000125132 (from geneSymbol) uc332rvv.1 uc332rvv.1 
ENSMUST00000268212.1 ENSMUSG00000125133 ENSMUST00000268212.1 ENSMUSG00000125133 (from geneSymbol) uc332rvz.1 uc332rvz.1 
ENSMUST00000268213.1 ENSMUSG00000125134 ENSMUST00000268213.1 ENSMUSG00000125134 (from geneSymbol) uc332rwa.1 uc332rwa.1 
ENSMUST00000268217.1 ENSMUSG00000125135 ENSMUST00000268217.1 ENSMUSG00000125135 (from geneSymbol) uc332rwe.1 uc332rwe.1 
ENSMUST00000268218.1 ENSMUSG00000125136 ENSMUST00000268218.1 ENSMUSG00000125136 (from geneSymbol) uc332rwf.1 uc332rwf.1 
ENSMUST00000268219.1 ENSMUSG00000125137 ENSMUST00000268219.1 ENSMUSG00000125137 (from geneSymbol) uc332rwg.1 uc332rwg.1 
ENSMUST00000268220.1 ENSMUSG00000125138 ENSMUST00000268220.1 ENSMUSG00000125138 (from geneSymbol) uc332rwh.1 uc332rwh.1 
ENSMUST00000268222.1 ENSMUSG00000125140 ENSMUST00000268222.1 ENSMUSG00000125140 (from geneSymbol) uc332rwi.1 uc332rwi.1 
ENSMUST00000268229.1 H2-K2 ENSMUST00000268229.1 H2-K2 (from geneSymbol) uc332rwp.1 uc332rwp.1 
ENSMUST00000268238.1 Gm15889 ENSMUST00000268238.1 Gm15889 (from geneSymbol) uc332rwy.1 uc332rwy.1 
ENSMUST00000268245.1 ENSMUSG00000125141 ENSMUST00000268245.1 ENSMUSG00000125141 (from geneSymbol) uc332rxf.1 uc332rxf.1 
ENSMUST00000268254.1 ENSMUSG00000125142 ENSMUST00000268254.1 ENSMUSG00000125142 (from geneSymbol) uc332rxo.1 uc332rxo.1 
ENSMUST00000268265.1 ENSMUSG00000125143 ENSMUST00000268265.1 ENSMUSG00000125143 (from geneSymbol) uc332rxz.1 uc332rxz.1 
ENSMUST00000268268.1 Dgkeos ENSMUST00000268268.1 Dgkeos (from geneSymbol) AK044435 uc332ryc.1 uc332ryc.1 
ENSMUST00000268275.1 ENSMUSG00000125144 ENSMUST00000268275.1 ENSMUSG00000125144 (from geneSymbol) uc332ryj.1 uc332ryj.1 
ENSMUST00000268283.1 ENSMUSG00000125145 ENSMUST00000268283.1 ENSMUSG00000125145 (from geneSymbol) uc332ryr.1 uc332ryr.1 
ENSMUST00000268350.1 ENSMUSG00000125146 ENSMUST00000268350.1 ENSMUSG00000125146 (from geneSymbol) uc332sax.1 uc332sax.1 
ENSMUST00000268351.1 ENSMUSG00000125147 ENSMUST00000268351.1 ENSMUSG00000125147 (from geneSymbol) uc332say.1 uc332say.1 
ENSMUST00000268352.1 ENSMUSG00000125148 ENSMUST00000268352.1 ENSMUSG00000125148 (from geneSymbol) uc332saz.1 uc332saz.1 
ENSMUST00000268353.1 Gm33424 ENSMUST00000268353.1 Gm33424 (from geneSymbol) AK132507 uc332sba.1 uc332sba.1 
ENSMUST00000268368.1 Gm57318 ENSMUST00000268368.1 Gm57318 (from geneSymbol) uc332sbo.1 uc332sbo.1 
ENSMUST00000268381.1 ENSMUSG00000125149 ENSMUST00000268381.1 ENSMUSG00000125149 (from geneSymbol) uc332scb.1 uc332scb.1 
ENSMUST00000268393.1 ENSMUSG00000125150 ENSMUST00000268393.1 ENSMUSG00000125150 (from geneSymbol) uc332scn.1 uc332scn.1 
ENSMUST00000268394.1 ENSMUSG00000121813 ENSMUST00000268394.1 ENSMUSG00000121813 (from geneSymbol) BC099450 uc332sco.1 uc332sco.1 
ENSMUST00000268418.1 ENSMUSG00000125151 ENSMUST00000268418.1 ENSMUSG00000125151 (from geneSymbol) uc332sdm.1 uc332sdm.1 
ENSMUST00000268419.1 ENSMUSG00000125152 ENSMUST00000268419.1 ENSMUSG00000125152 (from geneSymbol) uc332sdn.1 uc332sdn.1 
ENSMUST00000268421.1 ENSMUSG00000125153 ENSMUST00000268421.1 ENSMUSG00000125153 (from geneSymbol) uc332sdp.1 uc332sdp.1 
ENSMUST00000268422.1 ENSMUSG00000125154 ENSMUST00000268422.1 ENSMUSG00000125154 (from geneSymbol) uc332sdq.1 uc332sdq.1 
ENSMUST00000268433.1 Gm29346 ENSMUST00000268433.1 Gm29346 (from geneSymbol) uc332seb.1 uc332seb.1 
ENSMUST00000268458.1 ENSMUSG00000125155 ENSMUST00000268458.1 ENSMUSG00000125155 (from geneSymbol) uc332sfa.1 uc332sfa.1 
ENSMUST00000268463.1 Gm4419 ENSMUST00000268463.1 Gm4419 (from geneSymbol) uc332sff.1 uc332sff.1 
ENSMUST00000268488.1 4930455B14Rik ENSMUST00000268488.1 4930455B14Rik (from geneSymbol) AK132658 uc332sge.1 uc332sge.1 
ENSMUST00000268522.1 ENSMUSG00000125156 ENSMUST00000268522.1 ENSMUSG00000125156 (from geneSymbol) uc332shm.1 uc332shm.1 
ENSMUST00000268523.1 ENSMUSG00000125157 ENSMUST00000268523.1 ENSMUSG00000125157 (from geneSymbol) uc332shn.1 uc332shn.1 
ENSMUST00000268526.1 ENSMUSG00000125158 ENSMUST00000268526.1 ENSMUSG00000125158 (from geneSymbol) uc332shq.1 uc332shq.1 
ENSMUST00000268535.1 ENSMUSG00000125159 ENSMUST00000268535.1 ENSMUSG00000125159 (from geneSymbol) uc332shy.1 uc332shy.1 
ENSMUST00000268536.1 ENSMUSG00000125160 ENSMUST00000268536.1 ENSMUSG00000125160 (from geneSymbol) uc332shz.1 uc332shz.1 
ENSMUST00000268538.1 ENSMUSG00000125162 ENSMUST00000268538.1 ENSMUSG00000125162 (from geneSymbol) uc332sia.1 uc332sia.1 
ENSMUST00000268544.1 ENSMUSG00000125163 ENSMUST00000268544.1 ENSMUSG00000125163 (from geneSymbol) uc332sig.1 uc332sig.1 
ENSMUST00000268545.1 ENSMUSG00000125164 ENSMUST00000268545.1 ENSMUSG00000125164 (from geneSymbol) uc332sih.1 uc332sih.1 
ENSMUST00000268548.1 ENSMUSG00000125165 ENSMUST00000268548.1 ENSMUSG00000125165 (from geneSymbol) uc332sik.1 uc332sik.1 
ENSMUST00000268549.1 ENSMUSG00000125166 ENSMUST00000268549.1 ENSMUSG00000125166 (from geneSymbol) uc332sil.1 uc332sil.1 
ENSMUST00000268553.1 ENSMUSG00000125167 ENSMUST00000268553.1 ENSMUSG00000125167 (from geneSymbol) uc332sip.1 uc332sip.1 
ENSMUST00000268554.1 Gm56492 ENSMUST00000268554.1 Gm56492 (from geneSymbol) uc332siq.1 uc332siq.1 
ENSMUST00000268562.1 ENSMUSG00000125168 ENSMUST00000268562.1 ENSMUSG00000125168 (from geneSymbol) uc332siy.1 uc332siy.1 
ENSMUST00000268563.1 ENSMUSG00000125169 ENSMUST00000268563.1 ENSMUSG00000125169 (from geneSymbol) uc332siz.1 uc332siz.1 
ENSMUST00000268565.1 ENSMUSG00000125170 ENSMUST00000268565.1 ENSMUSG00000125170 (from geneSymbol) uc332sjb.1 uc332sjb.1 
ENSMUST00000268570.1 ENSMUSG00000125171 ENSMUST00000268570.1 ENSMUSG00000125171 (from geneSymbol) uc332sjg.1 uc332sjg.1 
ENSMUST00000268572.1 ENSMUSG00000125172 ENSMUST00000268572.1 ENSMUSG00000125172 (from geneSymbol) uc332sji.1 uc332sji.1 
ENSMUST00000268582.1 Gm39918 ENSMUST00000268582.1 Gm39918 (from geneSymbol) uc332sjs.1 uc332sjs.1 
ENSMUST00000268589.1 Gm31227 ENSMUST00000268589.1 Gm31227 (from geneSymbol) uc332sjz.1 uc332sjz.1 
ENSMUST00000268594.1 ENSMUSG00000125174 ENSMUST00000268594.1 ENSMUSG00000125174 (from geneSymbol) uc332ske.1 uc332ske.1 
ENSMUST00000268596.1 ENSMUSG00000125175 ENSMUST00000268596.1 ENSMUSG00000125175 (from geneSymbol) uc332skg.1 uc332skg.1 
ENSMUST00000268598.1 ENSMUSG00000125176 ENSMUST00000268598.1 ENSMUSG00000125176 (from geneSymbol) uc332ski.1 uc332ski.1 
ENSMUST00000268599.1 Gm46367 ENSMUST00000268599.1 Gm46367 (from geneSymbol) uc332skj.1 uc332skj.1 
ENSMUST00000268603.1 1700014F14Rik ENSMUST00000268603.1 1700014F14Rik (from geneSymbol) uc332skn.1 uc332skn.1 
ENSMUST00000268605.1 ENSMUSG00000125177 ENSMUST00000268605.1 ENSMUSG00000125177 (from geneSymbol) uc332skp.1 uc332skp.1 
ENSMUST00000268606.1 ENSMUSG00000125178 ENSMUST00000268606.1 ENSMUSG00000125178 (from geneSymbol) uc332skq.1 uc332skq.1 
ENSMUST00000268609.1 ENSMUSG00000125179 ENSMUST00000268609.1 ENSMUSG00000125179 (from geneSymbol) AK006954 uc332skt.1 uc332skt.1 
ENSMUST00000268612.1 Gm47757 ENSMUST00000268612.1 Gm47757 (from geneSymbol) uc332skw.1 uc332skw.1 
ENSMUST00000268630.1 2700038G22Rik ENSMUST00000268630.1 2700038G22Rik (from geneSymbol) AK002390 uc332slo.1 uc332slo.1 
ENSMUST00000268644.1 Gm11729 ENSMUST00000268644.1 Gm11729 (from geneSymbol) uc332smc.1 uc332smc.1 
ENSMUST00000268647.1 ENSMUSG00000125181 ENSMUST00000268647.1 ENSMUSG00000125181 (from geneSymbol) uc332smf.1 uc332smf.1 
ENSMUST00000268648.1 ENSMUSG00000125182 ENSMUST00000268648.1 ENSMUSG00000125182 (from geneSymbol) uc332smg.1 uc332smg.1 
ENSMUST00000268650.1 ENSMUSG00000125183 ENSMUST00000268650.1 ENSMUSG00000125183 (from geneSymbol) uc332smi.1 uc332smi.1 
ENSMUST00000268657.1 ENSMUSG00000125184 ENSMUST00000268657.1 ENSMUSG00000125184 (from geneSymbol) uc332smp.1 uc332smp.1 
ENSMUST00000268660.1 ENSMUSG00000125185 ENSMUST00000268660.1 ENSMUSG00000125185 (from geneSymbol) uc332sms.1 uc332sms.1 
ENSMUST00000268661.1 Gm48559 ENSMUST00000268661.1 Gm48559 (from geneSymbol) AK132890 uc332smt.1 uc332smt.1 
ENSMUST00000268664.1 1700022N22Rik ENSMUST00000268664.1 1700022N22Rik (from geneSymbol) AK006250 uc332smw.1 uc332smw.1 
ENSMUST00000268678.1 ENSMUSG00000125186 ENSMUST00000268678.1 ENSMUSG00000125186 (from geneSymbol) uc332snk.1 uc332snk.1 
ENSMUST00000268680.1 ENSMUSG00000125187 ENSMUST00000268680.1 ENSMUSG00000125187 (from geneSymbol) uc332snm.1 uc332snm.1 
ENSMUST00000268682.1 ENSMUSG00000125188 ENSMUST00000268682.1 ENSMUSG00000125188 (from geneSymbol) uc332sno.1 uc332sno.1 
ENSMUST00000268687.1 ENSMUSG00000125189 ENSMUST00000268687.1 ENSMUSG00000125189 (from geneSymbol) uc332snt.1 uc332snt.1 
ENSMUST00000268691.1 ENSMUSG00000125190 ENSMUST00000268691.1 ENSMUSG00000125190 (from geneSymbol) uc332snx.1 uc332snx.1 
ENSMUST00000268695.1 1700122H20Rik ENSMUST00000268695.1 1700122H20Rik (from geneSymbol) AK007238 uc332sob.1 uc332sob.1 
ENSMUST00000268702.1 ENSMUSG00000125191 ENSMUST00000268702.1 ENSMUSG00000125191 (from geneSymbol) uc332soi.1 uc332soi.1 
ENSMUST00000268706.1 ENSMUSG00000125192 ENSMUST00000268706.1 ENSMUSG00000125192 (from geneSymbol) uc332som.1 uc332som.1 
ENSMUST00000268711.1 Gm13166 ENSMUST00000268711.1 Gm13166 (from geneSymbol) AK006496 uc332sor.1 uc332sor.1 
ENSMUST00000268752.1 ENSMUSG00000125193 ENSMUST00000268752.1 ENSMUSG00000125193 (from geneSymbol) uc332sqg.1 uc332sqg.1 
ENSMUST00000268773.1 ENSMUSG00000125194 ENSMUST00000268773.1 ENSMUSG00000125194 (from geneSymbol) uc332srb.1 uc332srb.1 
ENSMUST00000268774.1 ENSMUSG00000125195 ENSMUST00000268774.1 ENSMUSG00000125195 (from geneSymbol) uc332src.1 uc332src.1 
ENSMUST00000268775.1 ENSMUSG00000125196 ENSMUST00000268775.1 ENSMUSG00000125196 (from geneSymbol) uc332srd.1 uc332srd.1 
ENSMUST00000268776.1 Gm36356 ENSMUST00000268776.1 predicted gene, 36356 (from RefSeq NR_166608.1) NR_166608 uc332sre.1 uc332sre.1 
ENSMUST00000268787.1 ENSMUSG00000125197 ENSMUST00000268787.1 ENSMUSG00000125197 (from geneSymbol) uc332sro.1 uc332sro.1 
ENSMUST00000268789.1 Gm26707 ENSMUST00000268789.1 Gm26707 (from geneSymbol) AK145457 uc332srq.1 uc332srq.1 
ENSMUST00000268793.1 ENSMUSG00000125198 ENSMUST00000268793.1 ENSMUSG00000125198 (from geneSymbol) uc332sru.1 uc332sru.1 
ENSMUST00000268799.1 Gm31450 ENSMUST00000268799.1 Gm31450 (from geneSymbol) uc332ssa.1 uc332ssa.1 
ENSMUST00000268801.1 ENSMUSG00000125199 ENSMUST00000268801.1 ENSMUSG00000125199 (from geneSymbol) uc332ssc.1 uc332ssc.1 
ENSMUST00000268811.1 ENSMUSG00000125200 ENSMUST00000268811.1 ENSMUSG00000125200 (from geneSymbol) uc332ssm.1 uc332ssm.1 
ENSMUST00000268817.1 ENSMUSG00000125201 ENSMUST00000268817.1 ENSMUSG00000125201 (from geneSymbol) uc332ssr.1 uc332ssr.1 
ENSMUST00000268821.1 ENSMUSG00000125202 ENSMUST00000268821.1 ENSMUSG00000125202 (from geneSymbol) uc332ssv.1 uc332ssv.1 
ENSMUST00000268823.1 ENSMUSG00000125203 ENSMUST00000268823.1 ENSMUSG00000125203 (from geneSymbol) uc332ssx.1 uc332ssx.1 
ENSMUST00000268824.1 ENSMUSG00000125204 ENSMUST00000268824.1 ENSMUSG00000125204 (from geneSymbol) uc332ssy.1 uc332ssy.1 
ENSMUST00000268828.1 ENSMUSG00000125205 ENSMUST00000268828.1 ENSMUSG00000125205 (from geneSymbol) uc332stc.1 uc332stc.1 
ENSMUST00000268829.1 ENSMUSG00000125206 ENSMUST00000268829.1 ENSMUSG00000125206 (from geneSymbol) uc332std.1 uc332std.1 
ENSMUST00000268834.1 ENSMUSG00000125207 ENSMUST00000268834.1 ENSMUSG00000125207 (from geneSymbol) LF202961 uc332sti.1 uc332sti.1 
ENSMUST00000268835.1 4930555M17Rik ENSMUST00000268835.1 4930555M17Rik (from geneSymbol) AK019767 uc332stj.1 uc332stj.1 
ENSMUST00000268838.1 AA388235 ENSMUST00000268838.1 AA388235 (from geneSymbol) uc332stm.1 uc332stm.1 
ENSMUST00000268844.1 ENSMUSG00000125208 ENSMUST00000268844.1 ENSMUSG00000125208 (from geneSymbol) uc332sts.1 uc332sts.1 
ENSMUST00000268846.1 ENSMUSG00000125209 ENSMUST00000268846.1 ENSMUSG00000125209 (from geneSymbol) uc332stt.1 uc332stt.1 
ENSMUST00000268848.1 G630018N14Rik ENSMUST00000268848.1 G630018N14Rik (from geneSymbol) AK143085 uc332stv.1 uc332stv.1 
ENSMUST00000268883.1 ENSMUSG00000125210 ENSMUST00000268883.1 ENSMUSG00000125210 (from geneSymbol) uc332sve.1 uc332sve.1 
ENSMUST00000268885.1 Gm34868 ENSMUST00000268885.1 Gm34868 (from geneSymbol) uc332svg.1 uc332svg.1 
ENSMUST00000268891.1 4930568A13Rik ENSMUST00000268891.1 4930568A13Rik (from geneSymbol) AK016245 uc332svm.1 uc332svm.1 
ENSMUST00000268900.1 ENSMUSG00000125211 ENSMUST00000268900.1 ENSMUSG00000125211 (from geneSymbol) uc332svv.1 uc332svv.1 
ENSMUST00000268909.1 ENSMUSG00000125212 ENSMUST00000268909.1 ENSMUSG00000125212 (from geneSymbol) uc332swe.1 uc332swe.1 
ENSMUST00000268939.1 ENSMUSG00000125214 ENSMUST00000268939.1 ENSMUSG00000125214 (from geneSymbol) uc332sxh.1 uc332sxh.1 
ENSMUST00000268941.1 ENSMUSG00000125215 ENSMUST00000268941.1 ENSMUSG00000125215 (from geneSymbol) uc332sxj.1 uc332sxj.1 
ENSMUST00000268942.1 ENSMUSG00000125216 ENSMUST00000268942.1 ENSMUSG00000125216 (from geneSymbol) uc332sxk.1 uc332sxk.1 
ENSMUST00000268943.1 ENSMUSG00000125217 ENSMUST00000268943.1 ENSMUSG00000125217 (from geneSymbol) uc332sxl.1 uc332sxl.1 
ENSMUST00000268945.1 ENSMUSG00000125218 ENSMUST00000268945.1 ENSMUSG00000125218 (from geneSymbol) uc332sxn.1 uc332sxn.1 
ENSMUST00000268946.1 ENSMUSG00000125219 ENSMUST00000268946.1 ENSMUSG00000125219 (from geneSymbol) uc332sxo.1 uc332sxo.1 
ENSMUST00000268949.1 ENSMUSG00000125220 ENSMUST00000268949.1 ENSMUSG00000125220 (from geneSymbol) uc332sxr.1 uc332sxr.1 
ENSMUST00000268963.1 ENSMUSG00000125221 ENSMUST00000268963.1 ENSMUSG00000125221 (from geneSymbol) uc332syf.1 uc332syf.1 
ENSMUST00000268964.1 ENSMUSG00000125222 ENSMUST00000268964.1 ENSMUSG00000125222 (from geneSymbol) uc332syg.1 uc332syg.1 
ENSMUST00000268966.1 ENSMUSG00000125223 ENSMUST00000268966.1 ENSMUSG00000125223 (from geneSymbol) uc332syi.1 uc332syi.1 
ENSMUST00000268968.1 ENSMUSG00000125224 ENSMUST00000268968.1 ENSMUSG00000125224 (from geneSymbol) uc332syk.1 uc332syk.1 
ENSMUST00000268969.1 ENSMUSG00000125225 ENSMUST00000268969.1 ENSMUSG00000125225 (from geneSymbol) uc332syl.1 uc332syl.1 
ENSMUST00000268970.1 Gm13403 ENSMUST00000268970.1 Gm13403 (from geneSymbol) AK162388 uc332sym.1 uc332sym.1 
ENSMUST00000268980.1 Gm3787 ENSMUST00000268980.1 Gm3787 (from geneSymbol) BC100417 uc332syw.1 uc332syw.1 
ENSMUST00000269000.1 Gm28055 ENSMUST00000269000.1 Gm28055 (from geneSymbol) uc332szq.1 uc332szq.1 
ENSMUST00000269001.1 ENSMUSG00000125226 ENSMUST00000269001.1 ENSMUSG00000125226 (from geneSymbol) uc332szr.1 uc332szr.1 
ENSMUST00000269005.1 Gm49723 ENSMUST00000269005.1 Gm49723 (from geneSymbol) AK131747 uc332szv.1 uc332szv.1 
ENSMUST00000269010.1 ENSMUSG00000125227 ENSMUST00000269010.1 ENSMUSG00000125227 (from geneSymbol) uc332taa.1 uc332taa.1 
ENSMUST00000269013.1 ENSMUSG00000125229 ENSMUST00000269013.1 ENSMUSG00000125229 (from geneSymbol) uc332tac.1 uc332tac.1 
ENSMUST00000269014.1 ENSMUSG00000125230 ENSMUST00000269014.1 ENSMUSG00000125230 (from geneSymbol) uc332tad.1 uc332tad.1 
ENSMUST00000269015.1 ENSMUSG00000125231 ENSMUST00000269015.1 ENSMUSG00000125231 (from geneSymbol) uc332tae.1 uc332tae.1 
ENSMUST00000269016.1 ENSMUSG00000125232 ENSMUST00000269016.1 ENSMUSG00000125232 (from geneSymbol) uc332taf.1 uc332taf.1 
ENSMUST00000269017.1 ENSMUSG00000125233 ENSMUST00000269017.1 ENSMUSG00000125233 (from geneSymbol) uc332tag.1 uc332tag.1 
ENSMUST00000269018.1 ENSMUSG00000125234 ENSMUST00000269018.1 ENSMUSG00000125234 (from geneSymbol) uc332tah.1 uc332tah.1 
ENSMUST00000269019.1 ENSMUSG00000125235 ENSMUST00000269019.1 ENSMUSG00000125235 (from geneSymbol) uc332tai.1 uc332tai.1 
ENSMUST00000269022.1 ENSMUSG00000125236 ENSMUST00000269022.1 ENSMUSG00000125236 (from geneSymbol) uc332tal.1 uc332tal.1 
ENSMUST00000269024.1 ENSMUSG00000125237 ENSMUST00000269024.1 ENSMUSG00000125237 (from geneSymbol) uc332tan.1 uc332tan.1 
ENSMUST00000269025.1 ENSMUSG00000125238 ENSMUST00000269025.1 ENSMUSG00000125238 (from geneSymbol) uc332tao.1 uc332tao.1 
ENSMUST00000269026.1 ENSMUSG00000125239 ENSMUST00000269026.1 ENSMUSG00000125239 (from geneSymbol) uc332tap.1 uc332tap.1 
ENSMUST00000269028.1 ENSMUSG00000125240 ENSMUST00000269028.1 ENSMUSG00000125240 (from geneSymbol) uc332tar.1 uc332tar.1 
ENSMUST00000269029.1 Gm57285 ENSMUST00000269029.1 Gm57285 (from geneSymbol) uc332tas.1 uc332tas.1 
ENSMUST00000269035.1 ENSMUSG00000125241 ENSMUST00000269035.1 ENSMUSG00000125241 (from geneSymbol) uc332tay.1 uc332tay.1 
ENSMUST00000269037.1 ENSMUSG00000125242 ENSMUST00000269037.1 ENSMUSG00000125242 (from geneSymbol) uc332tba.1 uc332tba.1 
ENSMUST00000269038.1 Gm28893 ENSMUST00000269038.1 Gm28893 (from geneSymbol) AK132874 uc332tbb.1 uc332tbb.1 
ENSMUST00000269055.1 Gm53617 ENSMUST00000269055.1 Gm53617 (from geneSymbol) uc332tbs.1 uc332tbs.1 
ENSMUST00000269072.1 4933427E13Rik ENSMUST00000269072.1 4933427E13Rik (from geneSymbol) AK016948 uc332tcj.1 uc332tcj.1 
ENSMUST00000269084.1 ENSMUSG00000125243 ENSMUST00000269084.1 ENSMUSG00000125243 (from geneSymbol) uc332tcv.1 uc332tcv.1 
ENSMUST00000269085.1 ENSMUSG00000125244 ENSMUST00000269085.1 ENSMUSG00000125244 (from geneSymbol) uc332tcw.1 uc332tcw.1 
ENSMUST00000269086.1 ENSMUSG00000125245 ENSMUST00000269086.1 ENSMUSG00000125245 (from geneSymbol) uc332tcx.1 uc332tcx.1 
ENSMUST00000269087.1 Gm6647 ENSMUST00000269087.1 Gm6647 (from geneSymbol) uc332tcy.1 uc332tcy.1 
ENSMUST00000269099.1 ENSMUSG00000125247 ENSMUST00000269099.1 ENSMUSG00000125247 (from geneSymbol) uc332tdk.1 uc332tdk.1 
ENSMUST00000269103.1 Gm40035 ENSMUST00000269103.1 Gm40035 (from geneSymbol) uc332tdo.1 uc332tdo.1 
ENSMUST00000269107.1 5033403F01Rik ENSMUST00000269107.1 5033403F01Rik (from geneSymbol) uc332tds.1 uc332tds.1 
ENSMUST00000269118.1 ENSMUSG00000125249 ENSMUST00000269118.1 ENSMUSG00000125249 (from geneSymbol) uc332ted.1 uc332ted.1 
ENSMUST00000269122.1 ENSMUSG00000125250 ENSMUST00000269122.1 ENSMUSG00000125250 (from geneSymbol) uc332teh.1 uc332teh.1 
ENSMUST00000269123.1 ENSMUSG00000125251 ENSMUST00000269123.1 ENSMUSG00000125251 (from geneSymbol) uc332tei.1 uc332tei.1 
ENSMUST00000269128.1 ENSMUSG00000125252 ENSMUST00000269128.1 ENSMUSG00000125252 (from geneSymbol) uc332ten.1 uc332ten.1 
ENSMUST00000269129.1 ENSMUSG00000125253 ENSMUST00000269129.1 ENSMUSG00000125253 (from geneSymbol) uc332teo.1 uc332teo.1 
ENSMUST00000269130.1 ENSMUSG00000125254 ENSMUST00000269130.1 ENSMUSG00000125254 (from geneSymbol) uc332tep.1 uc332tep.1 
ENSMUST00000269131.1 Gm12414 ENSMUST00000269131.1 Gm12414 (from geneSymbol) uc332teq.1 uc332teq.1 
ENSMUST00000269133.1 ENSMUSG00000125255 ENSMUST00000269133.1 ENSMUSG00000125255 (from geneSymbol) uc332tes.1 uc332tes.1 
ENSMUST00000269134.1 ENSMUSG00000125256 ENSMUST00000269134.1 ENSMUSG00000125256 (from geneSymbol) uc332tet.1 uc332tet.1 
ENSMUST00000269135.1 ENSMUSG00000125257 ENSMUST00000269135.1 ENSMUSG00000125257 (from geneSymbol) uc332teu.1 uc332teu.1 
ENSMUST00000269187.1 ENSMUSG00000125258 ENSMUST00000269187.1 ENSMUSG00000125258 (from geneSymbol) uc332tgu.1 uc332tgu.1 
ENSMUST00000269188.1 ENSMUSG00000125259 ENSMUST00000269188.1 ENSMUSG00000125259 (from geneSymbol) uc332tgv.1 uc332tgv.1 
ENSMUST00000269191.1 ENSMUSG00000125260 ENSMUST00000269191.1 ENSMUSG00000125260 (from geneSymbol) uc332tgy.1 uc332tgy.1 
ENSMUST00000269192.1 ENSMUSG00000125261 ENSMUST00000269192.1 ENSMUSG00000125261 (from geneSymbol) uc332tgz.1 uc332tgz.1 
ENSMUST00000269193.1 ENSMUSG00000125262 ENSMUST00000269193.1 ENSMUSG00000125262 (from geneSymbol) uc332tha.1 uc332tha.1 
ENSMUST00000269196.1 ENSMUSG00000125263 ENSMUST00000269196.1 ENSMUSG00000125263 (from geneSymbol) uc332thd.1 uc332thd.1 
ENSMUST00000269199.1 ENSMUSG00000125264 ENSMUST00000269199.1 ENSMUSG00000125264 (from geneSymbol) uc332thg.1 uc332thg.1 
ENSMUST00000269200.1 ENSMUSG00000125265 ENSMUST00000269200.1 ENSMUSG00000125265 (from geneSymbol) uc332thh.1 uc332thh.1 
ENSMUST00000269201.1 ENSMUSG00000125266 ENSMUST00000269201.1 ENSMUSG00000125266 (from geneSymbol) uc332thi.1 uc332thi.1 
ENSMUST00000269203.1 4930563H07Rik ENSMUST00000269203.1 4930563H07Rik (from geneSymbol) AK016206 uc332thk.1 uc332thk.1 
ENSMUST00000269204.1 ENSMUSG00000125267 ENSMUST00000269204.1 ENSMUSG00000125267 (from geneSymbol) uc332thl.1 uc332thl.1 
ENSMUST00000269205.1 Ppp1r18os ENSMUST00000269205.1 Ppp1r18os (from geneSymbol) uc332thm.1 uc332thm.1 
ENSMUST00000269208.1 ENSMUSG00000125268 ENSMUST00000269208.1 ENSMUSG00000125268 (from geneSymbol) uc332thp.1 uc332thp.1 
ENSMUST00000269209.1 ENSMUSG00000125269 ENSMUST00000269209.1 ENSMUSG00000125269 (from geneSymbol) uc332thq.1 uc332thq.1 
ENSMUST00000269216.1 ENSMUSG00000125270 ENSMUST00000269216.1 ENSMUSG00000125270 (from geneSymbol) uc332thx.1 uc332thx.1 
ENSMUST00000269217.1 ENSMUSG00000125271 ENSMUST00000269217.1 ENSMUSG00000125271 (from geneSymbol) uc332thy.1 uc332thy.1 
ENSMUST00000269220.1 ENSMUSG00000125272 ENSMUST00000269220.1 ENSMUSG00000125272 (from geneSymbol) uc332tib.1 uc332tib.1 
ENSMUST00000269221.1 ENSMUSG00000125273 ENSMUST00000269221.1 ENSMUSG00000125273 (from geneSymbol) uc332tic.1 uc332tic.1 
ENSMUST00000269223.1 ENSMUSG00000125274 ENSMUST00000269223.1 ENSMUSG00000125274 (from geneSymbol) uc332tie.1 uc332tie.1 
ENSMUST00000269225.1 ENSMUSG00000125275 ENSMUST00000269225.1 ENSMUSG00000125275 (from geneSymbol) uc332tig.1 uc332tig.1 
ENSMUST00000269226.1 ENSMUSG00000125276 ENSMUST00000269226.1 ENSMUSG00000125276 (from geneSymbol) uc332tih.1 uc332tih.1 
ENSMUST00000269227.1 3110056K07Rik ENSMUST00000269227.1 3110056K07Rik (from geneSymbol) AK077771 uc332tii.1 uc332tii.1 
ENSMUST00000269241.1 ENSMUSG00000125277 ENSMUST00000269241.1 ENSMUSG00000125277 (from geneSymbol) uc332tiw.1 uc332tiw.1 
ENSMUST00000269243.1 ENSMUSG00000125278 ENSMUST00000269243.1 ENSMUSG00000125278 (from geneSymbol) uc332tiy.1 uc332tiy.1 
ENSMUST00000269244.1 ENSMUSG00000125279 ENSMUST00000269244.1 ENSMUSG00000125279 (from geneSymbol) uc332tiz.1 uc332tiz.1 
ENSMUST00000269246.1 ENSMUSG00000125280 ENSMUST00000269246.1 ENSMUSG00000125280 (from geneSymbol) uc332tjb.1 uc332tjb.1 
ENSMUST00000269257.1 ENSMUSG00000125281 ENSMUST00000269257.1 ENSMUSG00000125281 (from geneSymbol) uc332tjl.1 uc332tjl.1 
ENSMUST00000269258.1 ENSMUSG00000125282 ENSMUST00000269258.1 ENSMUSG00000125282 (from geneSymbol) uc332tjm.1 uc332tjm.1 
ENSMUST00000269259.1 ENSMUSG00000125283 ENSMUST00000269259.1 ENSMUSG00000125283 (from geneSymbol) uc332tjn.1 uc332tjn.1 
ENSMUST00000269260.1 ENSMUSG00000125284 ENSMUST00000269260.1 ENSMUSG00000125284 (from geneSymbol) uc332tjo.1 uc332tjo.1 
ENSMUST00000269261.1 ENSMUSG00000125285 ENSMUST00000269261.1 ENSMUSG00000125285 (from geneSymbol) uc332tjp.1 uc332tjp.1 
ENSMUST00000269262.1 ENSMUSG00000125286 ENSMUST00000269262.1 ENSMUSG00000125286 (from geneSymbol) uc332tjq.1 uc332tjq.1 
ENSMUST00000269284.1 Gm9962 ENSMUST00000269284.1 Gm9962 (from geneSymbol) AK049950 uc332tkm.1 uc332tkm.1 
ENSMUST00000269286.1 ENSMUSG00000125287 ENSMUST00000269286.1 ENSMUSG00000125287 (from geneSymbol) uc332tko.1 uc332tko.1 
ENSMUST00000269293.1 ENSMUSG00000125288 ENSMUST00000269293.1 ENSMUSG00000125288 (from geneSymbol) uc332tkv.1 uc332tkv.1 
ENSMUST00000269294.1 ENSMUSG00000125289 ENSMUST00000269294.1 ENSMUSG00000125289 (from geneSymbol) uc332tkw.1 uc332tkw.1 
ENSMUST00000269295.1 ENSMUSG00000125290 ENSMUST00000269295.1 ENSMUSG00000125290 (from geneSymbol) uc332tkx.1 uc332tkx.1 
ENSMUST00000269296.1 ENSMUSG00000125291 ENSMUST00000269296.1 ENSMUSG00000125291 (from geneSymbol) uc332tky.1 uc332tky.1 
ENSMUST00000269297.1 ENSMUSG00000125292 ENSMUST00000269297.1 ENSMUSG00000125292 (from geneSymbol) uc332tkz.1 uc332tkz.1 
ENSMUST00000269303.1 ENSMUSG00000125293 ENSMUST00000269303.1 ENSMUSG00000125293 (from geneSymbol) uc332tlf.1 uc332tlf.1 
ENSMUST00000269304.1 ENSMUSG00000125294 ENSMUST00000269304.1 ENSMUSG00000125294 (from geneSymbol) uc332tlg.1 uc332tlg.1 
ENSMUST00000269306.1 ENSMUSG00000125295 ENSMUST00000269306.1 ENSMUSG00000125295 (from geneSymbol) uc332tli.1 uc332tli.1 
ENSMUST00000269307.1 ENSMUSG00000125296 ENSMUST00000269307.1 ENSMUSG00000125296 (from geneSymbol) uc332tlj.1 uc332tlj.1 
ENSMUST00000269308.1 Gm56947 ENSMUST00000269308.1 Gm56947 (from geneSymbol) uc332tlk.1 uc332tlk.1 
ENSMUST00000269309.1 ENSMUSG00000125297 ENSMUST00000269309.1 ENSMUSG00000125297 (from geneSymbol) uc332tll.1 uc332tll.1 
ENSMUST00000269311.1 ENSMUSG00000125298 ENSMUST00000269311.1 ENSMUSG00000125298 (from geneSymbol) uc332tln.1 uc332tln.1 
ENSMUST00000269313.1 ENSMUSG00000125300 ENSMUST00000269313.1 ENSMUSG00000125300 (from geneSymbol) uc332tlo.1 uc332tlo.1 
ENSMUST00000269314.1 ENSMUSG00000125301 ENSMUST00000269314.1 ENSMUSG00000125301 (from geneSymbol) uc332tlp.1 uc332tlp.1 
ENSMUST00000269316.1 ENSMUSG00000125302 ENSMUST00000269316.1 ENSMUSG00000125302 (from geneSymbol) uc332tlr.1 uc332tlr.1 
ENSMUST00000269346.1 ENSMUSG00000125303 ENSMUST00000269346.1 ENSMUSG00000125303 (from geneSymbol) uc332tmv.1 uc332tmv.1 
ENSMUST00000269360.1 ENSMUSG00000125304 ENSMUST00000269360.1 ENSMUSG00000125304 (from geneSymbol) uc332tnj.1 uc332tnj.1 
ENSMUST00000269361.1 ENSMUSG00000125305 ENSMUST00000269361.1 ENSMUSG00000125305 (from geneSymbol) uc332tnk.1 uc332tnk.1 
ENSMUST00000269362.1 1700085D22Rik ENSMUST00000269362.1 1700085D22Rik (from geneSymbol) uc332tnl.1 uc332tnl.1 
ENSMUST00000269369.1 Gm7644 ENSMUST00000269369.1 Gm7644 (from geneSymbol) AK087822 uc332tns.1 uc332tns.1 
ENSMUST00000269380.1 Gm9947 ENSMUST00000269380.1 Gm9947 (from geneSymbol) AK080352 uc332tod.1 uc332tod.1 
ENSMUST00000269394.1 ENSMUSG00000125306 ENSMUST00000269394.1 ENSMUSG00000125306 (from geneSymbol) uc332tor.1 uc332tor.1 
ENSMUST00000269396.1 ENSMUSG00000125307 ENSMUST00000269396.1 ENSMUSG00000125307 (from geneSymbol) uc332tot.1 uc332tot.1 
ENSMUST00000269397.1 ENSMUSG00000125308 ENSMUST00000269397.1 ENSMUSG00000125308 (from geneSymbol) uc332tou.1 uc332tou.1 
ENSMUST00000269398.1 ENSMUSG00000125309 ENSMUST00000269398.1 ENSMUSG00000125309 (from geneSymbol) uc332tov.1 uc332tov.1 
ENSMUST00000269399.1 ENSMUSG00000125310 ENSMUST00000269399.1 ENSMUSG00000125310 (from geneSymbol) uc332tow.1 uc332tow.1 
ENSMUST00000269400.1 ENSMUSG00000125311 ENSMUST00000269400.1 ENSMUSG00000125311 (from geneSymbol) uc332tox.1 uc332tox.1 
ENSMUST00000269402.1 ENSMUSG00000125312 ENSMUST00000269402.1 ENSMUSG00000125312 (from geneSymbol) uc332toz.1 uc332toz.1 
ENSMUST00000269404.1 ENSMUSG00000125314 ENSMUST00000269404.1 ENSMUSG00000125314 (from geneSymbol) LF204534 uc332tpa.1 uc332tpa.1 
ENSMUST00000269405.1 ENSMUSG00000125315 ENSMUST00000269405.1 ENSMUSG00000125315 (from geneSymbol) uc332tpb.1 uc332tpb.1 
ENSMUST00000269407.1 ENSMUSG00000125316 ENSMUST00000269407.1 ENSMUSG00000125316 (from geneSymbol) AK018986 uc332tpd.1 uc332tpd.1 
ENSMUST00000269408.1 ENSMUSG00000125317 ENSMUST00000269408.1 ENSMUSG00000125317 (from geneSymbol) uc332tpe.1 uc332tpe.1 
ENSMUST00000269413.1 ENSMUSG00000125319 ENSMUST00000269413.1 ENSMUSG00000125319 (from geneSymbol) uc332tpf.1 uc332tpf.1 
ENSMUST00000269414.1 ENSMUSG00000125320 ENSMUST00000269414.1 ENSMUSG00000125320 (from geneSymbol) uc332tpg.1 uc332tpg.1 
ENSMUST00000269415.1 Gm43700 ENSMUST00000269415.1 Gm43700 (from geneSymbol) uc332tph.1 uc332tph.1 
ENSMUST00000269431.1 Gm4189 ENSMUST00000269431.1 Gm4189 (from geneSymbol) uc332tpx.1 uc332tpx.1 
ENSMUST00000269437.1 ENSMUSG00000125321 ENSMUST00000269437.1 ENSMUSG00000125321 (from geneSymbol) uc332tqd.1 uc332tqd.1 
ENSMUST00000269438.1 ENSMUSG00000125322 ENSMUST00000269438.1 ENSMUSG00000125322 (from geneSymbol) uc332tqe.1 uc332tqe.1 
ENSMUST00000269443.1 Gm57084 ENSMUST00000269443.1 Gm57084 (from geneSymbol) uc332tqj.1 uc332tqj.1 
ENSMUST00000269446.1 ENSMUSG00000125323 ENSMUST00000269446.1 ENSMUSG00000125323 (from geneSymbol) uc332tqm.1 uc332tqm.1 
ENSMUST00000269447.1 ENSMUSG00000125324 ENSMUST00000269447.1 ENSMUSG00000125324 (from geneSymbol) LF201045 uc332tqn.1 uc332tqn.1 
ENSMUST00000269448.1 ENSMUSG00000125325 ENSMUST00000269448.1 ENSMUSG00000125325 (from geneSymbol) uc332tqo.1 uc332tqo.1 
ENSMUST00000269452.1 ENSMUSG00000125326 ENSMUST00000269452.1 ENSMUSG00000125326 (from geneSymbol) uc332tqs.1 uc332tqs.1 
ENSMUST00000269453.1 ENSMUSG00000125327 ENSMUST00000269453.1 ENSMUSG00000125327 (from geneSymbol) uc332tqt.1 uc332tqt.1 
ENSMUST00000269454.1 ENSMUSG00000125328 ENSMUST00000269454.1 ENSMUSG00000125328 (from geneSymbol) uc332tqu.1 uc332tqu.1 
ENSMUST00000269458.1 ENSMUSG00000125329 ENSMUST00000269458.1 ENSMUSG00000125329 (from geneSymbol) uc332tqy.1 uc332tqy.1 
ENSMUST00000269459.1 ENSMUSG00000125330 ENSMUST00000269459.1 ENSMUSG00000125330 (from geneSymbol) uc332tqz.1 uc332tqz.1 
ENSMUST00000269465.1 ENSMUSG00000125331 ENSMUST00000269465.1 ENSMUSG00000125331 (from geneSymbol) uc332trf.1 uc332trf.1 
ENSMUST00000269466.1 ENSMUSG00000125332 ENSMUST00000269466.1 ENSMUSG00000125332 (from geneSymbol) uc332trg.1 uc332trg.1 
ENSMUST00000269467.1 ENSMUSG00000125333 ENSMUST00000269467.1 ENSMUSG00000125333 (from geneSymbol) uc332trh.1 uc332trh.1 
ENSMUST00000269468.1 ENSMUSG00000125334 ENSMUST00000269468.1 ENSMUSG00000125334 (from geneSymbol) uc332tri.1 uc332tri.1 
ENSMUST00000269469.1 ENSMUSG00000125335 ENSMUST00000269469.1 ENSMUSG00000125335 (from geneSymbol) uc332trj.1 uc332trj.1 
ENSMUST00000269470.1 ENSMUSG00000125336 ENSMUST00000269470.1 ENSMUSG00000125336 (from geneSymbol) uc332trk.1 uc332trk.1 
ENSMUST00000269471.1 ENSMUSG00000125337 ENSMUST00000269471.1 ENSMUSG00000125337 (from geneSymbol) uc332trl.1 uc332trl.1 
ENSMUST00000269472.1 ENSMUSG00000125338 ENSMUST00000269472.1 ENSMUSG00000125338 (from geneSymbol) uc332trm.1 uc332trm.1 
ENSMUST00000269479.1 ENSMUSG00000125339 ENSMUST00000269479.1 ENSMUSG00000125339 (from geneSymbol) uc332trt.1 uc332trt.1 
ENSMUST00000269482.1 ENSMUSG00000125340 ENSMUST00000269482.1 ENSMUSG00000125340 (from geneSymbol) uc332trw.1 uc332trw.1 
ENSMUST00000269501.1 ENSMUSG00000125341 ENSMUST00000269501.1 ENSMUSG00000125341 (from geneSymbol) uc332tsp.1 uc332tsp.1 
ENSMUST00000269506.1 ENSMUSG00000125342 ENSMUST00000269506.1 ENSMUSG00000125342 (from geneSymbol) uc332tst.1 uc332tst.1 
ENSMUST00000269507.1 ENSMUSG00000125343 ENSMUST00000269507.1 ENSMUSG00000125343 (from geneSymbol) uc332tsu.1 uc332tsu.1 
ENSMUST00000269509.1 Gm35865 ENSMUST00000269509.1 Gm35865 (from geneSymbol) uc332tsw.1 uc332tsw.1 
ENSMUST00000269515.1 ENSMUSG00000125344 ENSMUST00000269515.1 ENSMUSG00000125344 (from geneSymbol) uc332ttc.1 uc332ttc.1 
ENSMUST00000269516.1 ENSMUSG00000125345 ENSMUST00000269516.1 ENSMUSG00000125345 (from geneSymbol) uc332ttd.1 uc332ttd.1 
ENSMUST00000269519.1 ENSMUSG00000125346 ENSMUST00000269519.1 ENSMUSG00000125346 (from geneSymbol) uc332ttg.1 uc332ttg.1 
ENSMUST00000269520.1 ENSMUSG00000125347 ENSMUST00000269520.1 ENSMUSG00000125347 (from geneSymbol) uc332tth.1 uc332tth.1 
ENSMUST00000269525.1 ENSMUSG00000125348 ENSMUST00000269525.1 ENSMUSG00000125348 (from geneSymbol) uc332ttm.1 uc332ttm.1 
ENSMUST00000269532.1 ENSMUSG00000125349 ENSMUST00000269532.1 ENSMUSG00000125349 (from geneSymbol) uc332ttt.1 uc332ttt.1 
ENSMUST00000269566.1 ENSMUSG00000125350 ENSMUST00000269566.1 ENSMUSG00000125350 (from geneSymbol) uc332tvb.1 uc332tvb.1 
ENSMUST00000269567.1 ENSMUSG00000125351 ENSMUST00000269567.1 ENSMUSG00000125351 (from geneSymbol) uc332tvc.1 uc332tvc.1 
ENSMUST00000269568.1 ENSMUSG00000125352 ENSMUST00000269568.1 ENSMUSG00000125352 (from geneSymbol) BC089467 uc332tvd.1 uc332tvd.1 
ENSMUST00000269570.1 ENSMUSG00000125353 ENSMUST00000269570.1 ENSMUSG00000125353 (from geneSymbol) uc332tvf.1 uc332tvf.1 
ENSMUST00000269579.1 ENSMUSG00000125354 ENSMUST00000269579.1 ENSMUSG00000125354 (from geneSymbol) uc332tvo.1 uc332tvo.1 
ENSMUST00000269581.1 Gm57070 ENSMUST00000269581.1 Gm57070 (from geneSymbol) uc332tvq.1 uc332tvq.1 
ENSMUST00000269586.1 ENSMUSG00000125355 ENSMUST00000269586.1 ENSMUSG00000125355 (from geneSymbol) uc332tvv.1 uc332tvv.1 
ENSMUST00000269588.1 ENSMUSG00000125356 ENSMUST00000269588.1 ENSMUSG00000125356 (from geneSymbol) uc332tvx.1 uc332tvx.1 
ENSMUST00000269589.1 ENSMUSG00000125357 ENSMUST00000269589.1 ENSMUSG00000125357 (from geneSymbol) uc332tvy.1 uc332tvy.1 
ENSMUST00000269591.1 ENSMUSG00000125358 ENSMUST00000269591.1 ENSMUSG00000125358 (from geneSymbol) uc332twa.1 uc332twa.1 
ENSMUST00000269594.1 ENSMUSG00000125359 ENSMUST00000269594.1 ENSMUSG00000125359 (from geneSymbol) uc332twd.1 uc332twd.1 
ENSMUST00000269595.1 Gm31597 ENSMUST00000269595.1 Gm31597 (from geneSymbol) uc332twe.1 uc332twe.1 
ENSMUST00000269598.1 ENSMUSG00000125360 ENSMUST00000269598.1 ENSMUSG00000125360 (from geneSymbol) uc332twh.1 uc332twh.1 
ENSMUST00000269611.1 Gm56524 ENSMUST00000269611.1 Gm56524 (from geneSymbol) uc332twl.1 uc332twl.1 
ENSMUST00000269617.1 ENSMUSG00000125362 ENSMUST00000269617.1 ENSMUSG00000125362 (from geneSymbol) uc332twr.1 uc332twr.1 
ENSMUST00000269620.1 ENSMUSG00000125363 ENSMUST00000269620.1 ENSMUSG00000125363 (from geneSymbol) uc332twu.1 uc332twu.1 
ENSMUST00000269624.1 ENSMUSG00000125364 ENSMUST00000269624.1 ENSMUSG00000125364 (from geneSymbol) uc332twy.1 uc332twy.1 
ENSMUST00000269626.1 ENSMUSG00000125365 ENSMUST00000269626.1 ENSMUSG00000125365 (from geneSymbol) uc332txa.1 uc332txa.1 
ENSMUST00000269630.1 ENSMUSG00000125366 ENSMUST00000269630.1 ENSMUSG00000125366 (from geneSymbol) uc332txe.1 uc332txe.1 
ENSMUST00000269631.1 Gm19412 ENSMUST00000269631.1 Gm19412 (from geneSymbol) AK140218 uc332txf.1 uc332txf.1 
ENSMUST00000269632.1 Gm33093 ENSMUST00000269632.1 Gm33093 (from geneSymbol) uc332txg.1 uc332txg.1 
ENSMUST00000269644.1 Gm42557 ENSMUST00000269644.1 Gm42557 (from geneSymbol) uc332txs.1 uc332txs.1 
ENSMUST00000269650.1 ENSMUSG00000125367 ENSMUST00000269650.1 ENSMUSG00000125367 (from geneSymbol) uc332txy.1 uc332txy.1 
ENSMUST00000269654.1 ENSMUSG00000125368 ENSMUST00000269654.1 ENSMUSG00000125368 (from geneSymbol) uc332tyc.1 uc332tyc.1 
ENSMUST00000269656.1 ENSMUSG00000125369 ENSMUST00000269656.1 ENSMUSG00000125369 (from geneSymbol) uc332tye.1 uc332tye.1 
ENSMUST00000269663.1 ENSMUSG00000125370 ENSMUST00000269663.1 ENSMUSG00000125370 (from geneSymbol) uc332tyl.1 uc332tyl.1 
ENSMUST00000269664.1 ENSMUSG00000125371 ENSMUST00000269664.1 ENSMUSG00000125371 (from geneSymbol) uc332tym.1 uc332tym.1 
ENSMUST00000269717.1 ENSMUSG00000125372 ENSMUST00000269717.1 ENSMUSG00000125372 (from geneSymbol) uc332uan.1 uc332uan.1 
ENSMUST00000269719.1 ENSMUSG00000125373 ENSMUST00000269719.1 ENSMUSG00000125373 (from geneSymbol) uc332uap.1 uc332uap.1 
ENSMUST00000269720.1 ENSMUSG00000125374 ENSMUST00000269720.1 ENSMUSG00000125374 (from geneSymbol) uc332uaq.1 uc332uaq.1 
ENSMUST00000269724.1 Gm12022 ENSMUST00000269724.1 Gm12022 (from geneSymbol) uc332uau.1 uc332uau.1 
ENSMUST00000269728.1 ENSMUSG00000125375 ENSMUST00000269728.1 ENSMUSG00000125375 (from geneSymbol) uc332uay.1 uc332uay.1 
ENSMUST00000269729.1 ENSMUSG00000125376 ENSMUST00000269729.1 ENSMUSG00000125376 (from geneSymbol) uc332uaz.1 uc332uaz.1 
ENSMUST00000269733.1 ENSMUSG00000125377 ENSMUST00000269733.1 ENSMUSG00000125377 (from geneSymbol) uc332ubd.1 uc332ubd.1 
ENSMUST00000269734.1 ENSMUSG00000125378 ENSMUST00000269734.1 ENSMUSG00000125378 (from geneSymbol) uc332ube.1 uc332ube.1 
ENSMUST00000269739.1 ENSMUSG00000125379 ENSMUST00000269739.1 ENSMUSG00000125379 (from geneSymbol) AK076685 uc332ubj.1 uc332ubj.1 
ENSMUST00000269743.1 ENSMUSG00000125380 ENSMUST00000269743.1 ENSMUSG00000125380 (from geneSymbol) uc332ubn.1 uc332ubn.1 
ENSMUST00000269747.1 ENSMUSG00000125381 ENSMUST00000269747.1 ENSMUSG00000125381 (from geneSymbol) uc332ubr.1 uc332ubr.1 
ENSMUST00000269748.1 ENSMUSG00000125382 ENSMUST00000269748.1 ENSMUSG00000125382 (from geneSymbol) uc332ubs.1 uc332ubs.1 
ENSMUST00000269750.1 ENSMUSG00000125383 ENSMUST00000269750.1 ENSMUSG00000125383 (from geneSymbol) uc332ubu.1 uc332ubu.1 
ENSMUST00000269753.1 Gm31048 ENSMUST00000269753.1 Gm31048 (from geneSymbol) uc332ubx.1 uc332ubx.1 
ENSMUST00000269759.1 ENSMUSG00000125384 ENSMUST00000269759.1 ENSMUSG00000125384 (from geneSymbol) uc332ucc.1 uc332ucc.1 
ENSMUST00000269761.1 ENSMUSG00000125385 ENSMUST00000269761.1 ENSMUSG00000125385 (from geneSymbol) AK017077 uc332ucd.1 uc332ucd.1 
ENSMUST00000269762.1 ENSMUSG00000125386 ENSMUST00000269762.1 ENSMUSG00000125386 (from geneSymbol) uc332uce.1 uc332uce.1 
ENSMUST00000269763.1 ENSMUSG00000125387 ENSMUST00000269763.1 ENSMUSG00000125387 (from geneSymbol) LF199371 uc332ucf.1 uc332ucf.1 
ENSMUST00000269764.1 ENSMUSG00000125388 ENSMUST00000269764.1 ENSMUSG00000125388 (from geneSymbol) uc332ucg.1 uc332ucg.1 
ENSMUST00000269765.1 ENSMUSG00000125389 ENSMUST00000269765.1 ENSMUSG00000125389 (from geneSymbol) uc332uch.1 uc332uch.1 
ENSMUST00000269773.1 ENSMUSG00000125390 ENSMUST00000269773.1 ENSMUSG00000125390 (from geneSymbol) uc332ucp.1 uc332ucp.1 
ENSMUST00000269774.1 ENSMUSG00000125391 ENSMUST00000269774.1 ENSMUSG00000125391 (from geneSymbol) uc332ucq.1 uc332ucq.1 
ENSMUST00000269776.1 ENSMUSG00000125392 ENSMUST00000269776.1 ENSMUSG00000125392 (from geneSymbol) uc332ucs.1 uc332ucs.1 
ENSMUST00000269780.1 ENSMUSG00000125393 ENSMUST00000269780.1 ENSMUSG00000125393 (from geneSymbol) uc332ucw.1 uc332ucw.1 
ENSMUST00000269781.1 ENSMUSG00000125394 ENSMUST00000269781.1 ENSMUSG00000125394 (from geneSymbol) uc332ucx.1 uc332ucx.1 
ENSMUST00000269786.1 ENSMUSG00000125395 ENSMUST00000269786.1 ENSMUSG00000125395 (from geneSymbol) uc332udc.1 uc332udc.1 
ENSMUST00000269787.1 ENSMUSG00000125396 ENSMUST00000269787.1 ENSMUSG00000125396 (from geneSymbol) uc332udd.1 uc332udd.1 
ENSMUST00000269792.1 ENSMUSG00000125397 ENSMUST00000269792.1 ENSMUSG00000125397 (from geneSymbol) AK131714 uc332udi.1 uc332udi.1 
ENSMUST00000269805.1 Gm45941 ENSMUST00000269805.1 Gm45941 (from geneSymbol) uc332udv.1 uc332udv.1 
ENSMUST00000269826.1 Gm32486 ENSMUST00000269826.1 Gm32486 (from geneSymbol) uc332ueq.1 uc332ueq.1 
ENSMUST00000269839.1 ENSMUSG00000125398 ENSMUST00000269839.1 ENSMUSG00000125398 (from geneSymbol) uc332ufd.1 uc332ufd.1 
ENSMUST00000269849.1 ENSMUSG00000125400 ENSMUST00000269849.1 ENSMUSG00000125400 (from geneSymbol) AK019598 uc332ufl.1 uc332ufl.1 
ENSMUST00000269866.1 Gm34284 ENSMUST00000269866.1 Gm34284 (from geneSymbol) AK132932 uc332ugc.1 uc332ugc.1 
ENSMUST00000269870.1 ENSMUSG00000125401 ENSMUST00000269870.1 ENSMUSG00000125401 (from geneSymbol) uc332ugg.1 uc332ugg.1 
ENSMUST00000269871.1 ENSMUSG00000125402 ENSMUST00000269871.1 ENSMUSG00000125402 (from geneSymbol) uc332ugh.1 uc332ugh.1 
ENSMUST00000269873.1 ENSMUSG00000125403 ENSMUST00000269873.1 ENSMUSG00000125403 (from geneSymbol) uc332ugj.1 uc332ugj.1 
ENSMUST00000269874.1 Gm56951 ENSMUST00000269874.1 Gm56951 (from geneSymbol) uc332ugk.1 uc332ugk.1 
ENSMUST00000269930.1 ENSMUSG00000125404 ENSMUST00000269930.1 ENSMUSG00000125404 (from geneSymbol) uc332uio.1 uc332uio.1 
ENSMUST00000269931.1 ENSMUSG00000125405 ENSMUST00000269931.1 ENSMUSG00000125405 (from geneSymbol) uc332uip.1 uc332uip.1 
ENSMUST00000269934.1 ENSMUSG00000125406 ENSMUST00000269934.1 ENSMUSG00000125406 (from geneSymbol) uc332uis.1 uc332uis.1 
ENSMUST00000269935.1 ENSMUSG00000125407 ENSMUST00000269935.1 ENSMUSG00000125407 (from geneSymbol) uc332uit.1 uc332uit.1 
ENSMUST00000269936.1 ENSMUSG00000125408 ENSMUST00000269936.1 ENSMUSG00000125408 (from geneSymbol) uc332uiu.1 uc332uiu.1 
ENSMUST00000269943.1 ENSMUSG00000125409 ENSMUST00000269943.1 ENSMUSG00000125409 (from geneSymbol) uc332ujb.1 uc332ujb.1 
ENSMUST00000269946.1 ENSMUSG00000125410 ENSMUST00000269946.1 ENSMUSG00000125410 (from geneSymbol) uc332uje.1 uc332uje.1 
ENSMUST00000269947.1 ENSMUSG00000125411 ENSMUST00000269947.1 ENSMUSG00000125411 (from geneSymbol) uc332ujf.1 uc332ujf.1 
ENSMUST00000269948.1 ENSMUSG00000125412 ENSMUST00000269948.1 ENSMUSG00000125412 (from geneSymbol) uc332ujg.1 uc332ujg.1 
ENSMUST00000269951.1 ENSMUSG00000125413 ENSMUST00000269951.1 ENSMUSG00000125413 (from geneSymbol) uc332ujj.1 uc332ujj.1 
ENSMUST00000269954.1 ENSMUSG00000125415 ENSMUST00000269954.1 ENSMUSG00000125415 (from geneSymbol) uc332ujl.1 uc332ujl.1 
ENSMUST00000269966.1 Gm12729 ENSMUST00000269966.1 Gm12729 (from geneSymbol) uc332ujx.1 uc332ujx.1 
ENSMUST00000270108.1 ENSMUSG00000125416 ENSMUST00000270108.1 ENSMUSG00000125416 (from geneSymbol) uc332upj.1 uc332upj.1 
ENSMUST00000270109.1 ENSMUSG00000125417 ENSMUST00000270109.1 ENSMUSG00000125417 (from geneSymbol) uc332upk.1 uc332upk.1 
ENSMUST00000270111.1 ENSMUSG00000125418 ENSMUST00000270111.1 ENSMUSG00000125418 (from geneSymbol) uc332upm.1 uc332upm.1 
ENSMUST00000270114.1 ENSMUSG00000125419 ENSMUST00000270114.1 ENSMUSG00000125419 (from geneSymbol) uc332upp.1 uc332upp.1 
ENSMUST00000270115.1 ENSMUSG00000125420 ENSMUST00000270115.1 ENSMUSG00000125420 (from geneSymbol) uc332upq.1 uc332upq.1 
ENSMUST00000270116.1 ENSMUSG00000125421 ENSMUST00000270116.1 ENSMUSG00000125421 (from geneSymbol) uc332upr.1 uc332upr.1 
ENSMUST00000270117.1 Gm52147 ENSMUST00000270117.1 Gm52147 (from geneSymbol) uc332ups.1 uc332ups.1 
ENSMUST00000270121.1 ENSMUSG00000125422 ENSMUST00000270121.1 ENSMUSG00000125422 (from geneSymbol) uc332upu.1 uc332upu.1 
ENSMUST00000270122.1 ENSMUSG00000125423 ENSMUST00000270122.1 ENSMUSG00000125423 (from geneSymbol) uc332upv.1 uc332upv.1 
ENSMUST00000270123.1 ENSMUSG00000125424 ENSMUST00000270123.1 ENSMUSG00000125424 (from geneSymbol) uc332upw.1 uc332upw.1 
ENSMUST00000270124.1 ENSMUSG00000125425 ENSMUST00000270124.1 ENSMUSG00000125425 (from geneSymbol) uc332upx.1 uc332upx.1 
ENSMUST00000270128.1 1810006J02Rik ENSMUST00000270128.1 1810006J02Rik (from geneSymbol) AK007349 uc332uqb.1 uc332uqb.1 
ENSMUST00000270139.1 Gm7160 ENSMUST00000270139.1 Gm7160 (from geneSymbol) uc332uqm.1 uc332uqm.1 
ENSMUST00000270169.1 ENSMUSG00000125426 ENSMUST00000270169.1 ENSMUSG00000125426 (from geneSymbol) uc332urq.1 uc332urq.1 
ENSMUST00000270173.1 ENSMUSG00000125427 ENSMUST00000270173.1 ENSMUSG00000125427 (from geneSymbol) uc332uru.1 uc332uru.1 
ENSMUST00000270175.1 ENSMUSG00000125428 ENSMUST00000270175.1 ENSMUSG00000125428 (from geneSymbol) uc332urw.1 uc332urw.1 
ENSMUST00000270178.1 ENSMUSG00000125429 ENSMUST00000270178.1 ENSMUSG00000125429 (from geneSymbol) uc332urz.1 uc332urz.1 
ENSMUST00000270182.1 Gm20485 ENSMUST00000270182.1 Gm20485 (from geneSymbol) uc332usc.1 uc332usc.1 
ENSMUST00000270187.1 ENSMUSG00000125430 ENSMUST00000270187.1 ENSMUSG00000125430 (from geneSymbol) uc332ush.1 uc332ush.1 
ENSMUST00000270189.1 1700086P04Rik ENSMUST00000270189.1 1700086P04Rik (from geneSymbol) AK007024 uc332usj.1 uc332usj.1 
ENSMUST00000270200.1 ENSMUSG00000125431 ENSMUST00000270200.1 ENSMUSG00000125431 (from geneSymbol) uc332usu.1 uc332usu.1 
ENSMUST00000270207.1 ENSMUSG00000125432 ENSMUST00000270207.1 ENSMUSG00000125432 (from geneSymbol) uc332utb.1 uc332utb.1 
ENSMUST00000270214.1 ENSMUSG00000125433 ENSMUST00000270214.1 ENSMUSG00000125433 (from geneSymbol) uc332uti.1 uc332uti.1 
ENSMUST00000270216.1 ENSMUSG00000125434 ENSMUST00000270216.1 ENSMUSG00000125434 (from geneSymbol) uc332utk.1 uc332utk.1 
ENSMUST00000270217.1 ENSMUSG00000125435 ENSMUST00000270217.1 ENSMUSG00000125435 (from geneSymbol) uc332utl.1 uc332utl.1 
ENSMUST00000270219.1 ENSMUSG00000125436 ENSMUST00000270219.1 ENSMUSG00000125436 (from geneSymbol) uc332utn.1 uc332utn.1 
ENSMUST00000270231.1 ENSMUSG00000125437 ENSMUST00000270231.1 ENSMUSG00000125437 (from geneSymbol) uc332utz.1 uc332utz.1 
ENSMUST00000270236.1 ENSMUSG00000125440 ENSMUST00000270236.1 ENSMUSG00000125440 (from geneSymbol) uc332uua.1 uc332uua.1 
ENSMUST00000270247.1 ENSMUSG00000125441 ENSMUST00000270247.1 ENSMUSG00000125441 (from geneSymbol) uc332uul.1 uc332uul.1 
ENSMUST00000270259.1 ENSMUSG00000125442 ENSMUST00000270259.1 ENSMUSG00000125442 (from geneSymbol) uc332uux.1 uc332uux.1 
ENSMUST00000270260.1 ENSMUSG00000125443 ENSMUST00000270260.1 ENSMUSG00000125443 (from geneSymbol) uc332uuy.1 uc332uuy.1 
ENSMUST00000270261.1 ENSMUSG00000125444 ENSMUST00000270261.1 ENSMUSG00000125444 (from geneSymbol) uc332uuz.1 uc332uuz.1 
ENSMUST00000270263.1 ENSMUSG00000125445 ENSMUST00000270263.1 ENSMUSG00000125445 (from geneSymbol) uc332uvb.1 uc332uvb.1 
ENSMUST00000270267.1 ENSMUSG00000125446 ENSMUST00000270267.1 ENSMUSG00000125446 (from geneSymbol) uc332uvf.1 uc332uvf.1 
ENSMUST00000270270.1 ENSMUSG00000125447 ENSMUST00000270270.1 ENSMUSG00000125447 (from geneSymbol) uc332uvi.1 uc332uvi.1 
ENSMUST00000270273.1 ENSMUSG00000125448 ENSMUST00000270273.1 ENSMUSG00000125448 (from geneSymbol) uc332uvl.1 uc332uvl.1 
ENSMUST00000270274.1 ENSMUSG00000125449 ENSMUST00000270274.1 ENSMUSG00000125449 (from geneSymbol) uc332uvm.1 uc332uvm.1 
ENSMUST00000270275.1 ENSMUSG00000125450 ENSMUST00000270275.1 ENSMUSG00000125450 (from geneSymbol) uc332uvn.1 uc332uvn.1 
ENSMUST00000270276.1 ENSMUSG00000125451 ENSMUST00000270276.1 ENSMUSG00000125451 (from geneSymbol) uc332uvo.1 uc332uvo.1 
ENSMUST00000270280.1 ENSMUSG00000125452 ENSMUST00000270280.1 ENSMUSG00000125452 (from geneSymbol) uc332uvs.1 uc332uvs.1 
ENSMUST00000270281.1 ENSMUSG00000125453 ENSMUST00000270281.1 ENSMUSG00000125453 (from geneSymbol) uc332uvt.1 uc332uvt.1 
ENSMUST00000270315.1 ENSMUSG00000125454 ENSMUST00000270315.1 ENSMUSG00000125454 (from geneSymbol) LF195314 uc332uxb.1 uc332uxb.1 
ENSMUST00000270331.1 ENSMUSG00000125455 ENSMUST00000270331.1 ENSMUSG00000125455 (from geneSymbol) AK040954 uc332uxr.1 uc332uxr.1 
ENSMUST00000270333.1 ENSMUSG00000125456 ENSMUST00000270333.1 ENSMUSG00000125456 (from geneSymbol) uc332uxt.1 uc332uxt.1 
ENSMUST00000270337.1 ENSMUSG00000125457 ENSMUST00000270337.1 ENSMUSG00000125457 (from geneSymbol) uc332uxx.1 uc332uxx.1 
ENSMUST00000270338.1 ENSMUSG00000125458 ENSMUST00000270338.1 predicted gene, 31057 (from RefSeq NR_168571.1) NR_168571 uc332uxy.1 uc332uxy.1 
ENSMUST00000270339.1 ENSMUSG00000125459 ENSMUST00000270339.1 ENSMUSG00000125459 (from geneSymbol) uc332uxz.1 uc332uxz.1 
ENSMUST00000270340.1 ENSMUSG00000125460 ENSMUST00000270340.1 ENSMUSG00000125460 (from geneSymbol) uc332uya.1 uc332uya.1 
ENSMUST00000270342.1 ENSMUSG00000125461 ENSMUST00000270342.1 ENSMUSG00000125461 (from geneSymbol) uc332uyc.1 uc332uyc.1 
ENSMUST00000270344.1 ENSMUSG00000125462 ENSMUST00000270344.1 ENSMUSG00000125462 (from geneSymbol) uc332uye.1 uc332uye.1 
ENSMUST00000270345.1 ENSMUSG00000125463 ENSMUST00000270345.1 ENSMUSG00000125463 (from geneSymbol) uc332uyf.1 uc332uyf.1 
ENSMUST00000270346.1 ENSMUSG00000125464 ENSMUST00000270346.1 ENSMUSG00000125464 (from geneSymbol) uc332uyg.1 uc332uyg.1 
ENSMUST00000270348.1 ENSMUSG00000125465 ENSMUST00000270348.1 ENSMUSG00000125465 (from geneSymbol) uc332uyi.1 uc332uyi.1 
ENSMUST00000270349.1 ENSMUSG00000125466 ENSMUST00000270349.1 ENSMUSG00000125466 (from geneSymbol) uc332uyj.1 uc332uyj.1 
ENSMUST00000270358.1 ENSMUSG00000125467 ENSMUST00000270358.1 ENSMUSG00000125467 (from geneSymbol) uc332uys.1 uc332uys.1 
ENSMUST00000270359.1 ENSMUSG00000125468 ENSMUST00000270359.1 ENSMUSG00000125468 (from geneSymbol) uc332uyt.1 uc332uyt.1 
ENSMUST00000270365.1 Gm12724 ENSMUST00000270365.1 Gm12724 (from geneSymbol) AK139665 uc332uyz.1 uc332uyz.1 
ENSMUST00000270366.1 ENSMUSG00000125469 ENSMUST00000270366.1 ENSMUSG00000125469 (from geneSymbol) uc332uza.1 uc332uza.1 
ENSMUST00000270425.1 ENSMUSG00000125470 ENSMUST00000270425.1 ENSMUSG00000125470 (from geneSymbol) uc332vbh.1 uc332vbh.1 
ENSMUST00000270426.1 ENSMUSG00000125471 ENSMUST00000270426.1 ENSMUSG00000125471 (from geneSymbol) uc332vbi.1 uc332vbi.1 
ENSMUST00000270427.1 ENSMUSG00000125472 ENSMUST00000270427.1 ENSMUSG00000125472 (from geneSymbol) uc332vbj.1 uc332vbj.1 
ENSMUST00000270430.1 ENSMUSG00000125473 ENSMUST00000270430.1 ENSMUSG00000125473 (from geneSymbol) uc332vbm.1 uc332vbm.1 
ENSMUST00000270433.1 ENSMUSG00000125475 ENSMUST00000270433.1 ENSMUSG00000125475 (from geneSymbol) uc332vbo.1 uc332vbo.1 
ENSMUST00000270435.1 ENSMUSG00000125476 ENSMUST00000270435.1 ENSMUSG00000125476 (from geneSymbol) uc332vbq.1 uc332vbq.1 
ENSMUST00000270437.1 ENSMUSG00000125477 ENSMUST00000270437.1 ENSMUSG00000125477 (from geneSymbol) uc332vbs.1 uc332vbs.1 
ENSMUST00000270439.1 ENSMUSG00000125478 ENSMUST00000270439.1 ENSMUSG00000125478 (from geneSymbol) uc332vbu.1 uc332vbu.1 
ENSMUST00000270441.1 Gm14317 ENSMUST00000270441.1 Gm14317 (from geneSymbol) AK043662 uc332vbw.1 uc332vbw.1 
ENSMUST00000270452.1 ENSMUSG00000125479 ENSMUST00000270452.1 ENSMUSG00000125479 (from geneSymbol) uc332vch.1 uc332vch.1 
ENSMUST00000270454.1 ENSMUSG00000125480 ENSMUST00000270454.1 ENSMUSG00000125480 (from geneSymbol) uc332vcj.1 uc332vcj.1 
ENSMUST00000270456.1 ENSMUSG00000125481 ENSMUST00000270456.1 ENSMUSG00000125481 (from geneSymbol) uc332vcl.1 uc332vcl.1 
ENSMUST00000270458.1 ENSMUSG00000125482 ENSMUST00000270458.1 ENSMUSG00000125482 (from geneSymbol) uc332vcn.1 uc332vcn.1 
ENSMUST00000270459.1 ENSMUSG00000125483 ENSMUST00000270459.1 ENSMUSG00000125483 (from geneSymbol) uc332vco.1 uc332vco.1 
ENSMUST00000270461.1 ENSMUSG00000125484 ENSMUST00000270461.1 ENSMUSG00000125484 (from geneSymbol) uc332vcq.1 uc332vcq.1 
ENSMUST00000270464.1 4930520P13Rik ENSMUST00000270464.1 4930520P13Rik (from geneSymbol) AK015856 uc332vct.1 uc332vct.1 
ENSMUST00000270478.1 Gm36855 ENSMUST00000270478.1 predicted gene, 36855, transcript variant 3 (from RefSeq NR_175912.1) NR_175912 uc332vdg.1 uc332vdg.1 
ENSMUST00000270499.1 ENSMUSG00000125486 ENSMUST00000270499.1 ENSMUSG00000125486 (from geneSymbol) uc332veb.1 uc332veb.1 
ENSMUST00000270500.1 ENSMUSG00000125487 ENSMUST00000270500.1 ENSMUSG00000125487 (from geneSymbol) uc332vec.1 uc332vec.1 
ENSMUST00000270501.1 ENSMUSG00000125488 ENSMUST00000270501.1 ENSMUSG00000125488 (from geneSymbol) uc332ved.1 uc332ved.1 
ENSMUST00000270507.1 ENSMUSG00000125489 ENSMUST00000270507.1 ENSMUSG00000125489 (from geneSymbol) uc332vej.1 uc332vej.1 
ENSMUST00000270508.1 ENSMUSG00000125490 ENSMUST00000270508.1 ENSMUSG00000125490 (from geneSymbol) uc332vek.1 uc332vek.1 
ENSMUST00000270509.1 ENSMUSG00000125491 ENSMUST00000270509.1 ENSMUSG00000125491 (from geneSymbol) uc332vel.1 uc332vel.1 
ENSMUST00000270516.1 ENSMUSG00000125493 ENSMUST00000270516.1 ENSMUSG00000125493 (from geneSymbol) uc332ven.1 uc332ven.1 
ENSMUST00000270519.1 ENSMUSG00000125494 ENSMUST00000270519.1 ENSMUSG00000125494 (from geneSymbol) uc332veq.1 uc332veq.1 
ENSMUST00000270520.1 ENSMUSG00000125495 ENSMUST00000270520.1 ENSMUSG00000125495 (from geneSymbol) uc332ver.1 uc332ver.1 
ENSMUST00000270526.1 ENSMUSG00000125496 ENSMUST00000270526.1 ENSMUSG00000125496 (from geneSymbol) AK007187 uc332vex.1 uc332vex.1 
ENSMUST00000270532.1 ENSMUSG00000125497 ENSMUST00000270532.1 ENSMUSG00000125497 (from geneSymbol) uc332vfd.1 uc332vfd.1 
ENSMUST00000270533.1 Gm15322 ENSMUST00000270533.1 Gm15322 (from geneSymbol) uc332vfe.1 uc332vfe.1 
ENSMUST00000270534.1 ENSMUSG00000125498 ENSMUST00000270534.1 ENSMUSG00000125498 (from geneSymbol) uc332vff.1 uc332vff.1 
ENSMUST00000270535.1 Gm35612 ENSMUST00000270535.1 Gm35612 (from geneSymbol) KY468249 uc332vfg.1 uc332vfg.1 
ENSMUST00000270554.1 4930471G24Rik ENSMUST00000270554.1 4930471G24Rik (from geneSymbol) AK015551 uc332vfz.1 uc332vfz.1 
ENSMUST00000270557.1 ENSMUSG00000125499 ENSMUST00000270557.1 ENSMUSG00000125499 (from geneSymbol) uc332vgc.1 uc332vgc.1 
ENSMUST00000270567.1 ENSMUSG00000125500 ENSMUST00000270567.1 ENSMUSG00000125500 (from geneSymbol) uc332vgm.1 uc332vgm.1 
ENSMUST00000270573.1 ENSMUSG00000125501 ENSMUST00000270573.1 ENSMUSG00000125501 (from geneSymbol) uc332vgs.1 uc332vgs.1 
ENSMUST00000270574.1 ENSMUSG00000125502 ENSMUST00000270574.1 ENSMUSG00000125502 (from geneSymbol) uc332vgt.1 uc332vgt.1 
ENSMUST00000270575.1 ENSMUSG00000125503 ENSMUST00000270575.1 ENSMUSG00000125503 (from geneSymbol) uc332vgu.1 uc332vgu.1 
ENSMUST00000270578.1 ENSMUSG00000125504 ENSMUST00000270578.1 ENSMUSG00000125504 (from geneSymbol) uc332vgx.1 uc332vgx.1 
ENSMUST00000270580.1 ENSMUSG00000125505 ENSMUST00000270580.1 ENSMUSG00000125505 (from geneSymbol) uc332vgz.1 uc332vgz.1 
ENSMUST00000270581.1 ENSMUSG00000125506 ENSMUST00000270581.1 ENSMUSG00000125506 (from geneSymbol) uc332vha.1 uc332vha.1 
ENSMUST00000270582.1 ENSMUSG00000125507 ENSMUST00000270582.1 ENSMUSG00000125507 (from geneSymbol) uc332vhb.1 uc332vhb.1 
ENSMUST00000270583.1 ENSMUSG00000125508 ENSMUST00000270583.1 ENSMUSG00000125508 (from geneSymbol) uc332vhc.1 uc332vhc.1 
ENSMUST00000270584.1 ENSMUSG00000125509 ENSMUST00000270584.1 ENSMUSG00000125509 (from geneSymbol) uc332vhd.1 uc332vhd.1 
ENSMUST00000270588.1 ENSMUSG00000125510 ENSMUST00000270588.1 ENSMUSG00000125510 (from geneSymbol) uc332vhh.1 uc332vhh.1 
ENSMUST00000270589.1 ENSMUSG00000125511 ENSMUST00000270589.1 ENSMUSG00000125511 (from geneSymbol) uc332vhi.1 uc332vhi.1 
ENSMUST00000270593.1 ENSMUSG00000125512 ENSMUST00000270593.1 ENSMUSG00000125512 (from geneSymbol) uc332vhj.1 uc332vhj.1 
ENSMUST00000270594.1 ENSMUSG00000125513 ENSMUST00000270594.1 ENSMUSG00000125513 (from geneSymbol) uc332vhk.1 uc332vhk.1 
ENSMUST00000270598.1 ENSMUSG00000125514 ENSMUST00000270598.1 ENSMUSG00000125514 (from geneSymbol) uc332vho.1 uc332vho.1 
ENSMUST00000270599.1 ENSMUSG00000125515 ENSMUST00000270599.1 ENSMUSG00000125515 (from geneSymbol) uc332vhp.1 uc332vhp.1 
ENSMUST00000270601.1 Gm31812 ENSMUST00000270601.1 Gm31812 (from geneSymbol) uc332vhr.1 uc332vhr.1 
ENSMUST00000270605.1 ENSMUSG00000125516 ENSMUST00000270605.1 ENSMUSG00000125516 (from geneSymbol) uc332vhv.1 uc332vhv.1 
ENSMUST00000270618.1 ENSMUSG00000125517 ENSMUST00000270618.1 ENSMUSG00000125517 (from geneSymbol) uc332vii.1 uc332vii.1 
ENSMUST00000270632.1 ENSMUSG00000125518 ENSMUST00000270632.1 ENSMUSG00000125518 (from geneSymbol) uc332viw.1 uc332viw.1 
ENSMUST00000270637.1 Gm33890 ENSMUST00000270637.1 Gm33890 (from geneSymbol) uc332vjb.1 uc332vjb.1 
ENSMUST00000270639.1 ENSMUSG00000125519 ENSMUST00000270639.1 ENSMUSG00000125519 (from geneSymbol) uc332vjd.1 uc332vjd.1 
ENSMUST00000270645.1 ENSMUSG00000125520 ENSMUST00000270645.1 ENSMUSG00000125520 (from geneSymbol) uc332vjj.1 uc332vjj.1 
ENSMUST00000270647.1 ENSMUSG00000125521 ENSMUST00000270647.1 ENSMUSG00000125521 (from geneSymbol) uc332vjl.1 uc332vjl.1 
ENSMUST00000270651.1 ENSMUSG00000125522 ENSMUST00000270651.1 ENSMUSG00000125522 (from geneSymbol) uc332vjp.1 uc332vjp.1 
ENSMUST00000270652.1 ENSMUSG00000125523 ENSMUST00000270652.1 ENSMUSG00000125523 (from geneSymbol) uc332vjq.1 uc332vjq.1 
ENSMUST00000270653.1 ENSMUSG00000125524 ENSMUST00000270653.1 ENSMUSG00000125524 (from geneSymbol) uc332vjr.1 uc332vjr.1 
ENSMUST00000270655.1 ENSMUSG00000125525 ENSMUST00000270655.1 ENSMUSG00000125525 (from geneSymbol) uc332vjt.1 uc332vjt.1 
ENSMUST00000270658.1 4930520K02Rik ENSMUST00000270658.1 4930520K02Rik (from geneSymbol) AK019688 uc332vjw.1 uc332vjw.1 
ENSMUST00000270660.1 Gm3970 ENSMUST00000270660.1 Gm3970 (from geneSymbol) AK133032 uc332vjy.1 uc332vjy.1 
ENSMUST00000270664.1 ENSMUSG00000125526 ENSMUST00000270664.1 ENSMUSG00000125526 (from geneSymbol) BC030479 uc332vkc.1 uc332vkc.1 
ENSMUST00000270666.1 ENSMUSG00000125527 ENSMUST00000270666.1 ENSMUSG00000125527 (from geneSymbol) uc332vke.1 uc332vke.1 
ENSMUST00000270670.1 ENSMUSG00000125528 ENSMUST00000270670.1 ENSMUSG00000125528 (from geneSymbol) uc332vki.1 uc332vki.1 
ENSMUST00000270671.1 ENSMUSG00000125529 ENSMUST00000270671.1 ENSMUSG00000125529 (from geneSymbol) uc332vkj.1 uc332vkj.1 
ENSMUST00000270675.1 Gm16322 ENSMUST00000270675.1 Gm16322 (from geneSymbol) KY468216 uc332vkm.1 uc332vkm.1 
ENSMUST00000270688.1 ENSMUSG00000125531 ENSMUST00000270688.1 ENSMUSG00000125531 (from geneSymbol) uc332vkz.1 uc332vkz.1 
ENSMUST00000270689.1 ENSMUSG00000125532 ENSMUST00000270689.1 ENSMUSG00000125532 (from geneSymbol) uc332vla.1 uc332vla.1 
ENSMUST00000270697.1 Gm35158 ENSMUST00000270697.1 Gm35158 (from geneSymbol) uc332vli.1 uc332vli.1 
ENSMUST00000270699.1 ENSMUSG00000125534 ENSMUST00000270699.1 ENSMUSG00000125534 (from geneSymbol) uc332vlk.1 uc332vlk.1 
ENSMUST00000270700.1 ENSMUSG00000125535 ENSMUST00000270700.1 ENSMUSG00000125535 (from geneSymbol) uc332vll.1 uc332vll.1 
ENSMUST00000270701.1 ENSMUSG00000125536 ENSMUST00000270701.1 ENSMUSG00000125536 (from geneSymbol) uc332vlm.1 uc332vlm.1 
ENSMUST00000270706.1 ENSMUSG00000125537 ENSMUST00000270706.1 ENSMUSG00000125537 (from geneSymbol) uc332vlr.1 uc332vlr.1 
ENSMUST00000270707.1 ENSMUSG00000125538 ENSMUST00000270707.1 ENSMUSG00000125538 (from geneSymbol) uc332vls.1 uc332vls.1 
ENSMUST00000270708.1 ENSMUSG00000125539 ENSMUST00000270708.1 ENSMUSG00000125539 (from geneSymbol) uc332vlt.1 uc332vlt.1 
ENSMUST00000270709.1 ENSMUSG00000125540 ENSMUST00000270709.1 ENSMUSG00000125540 (from geneSymbol) uc332vlu.1 uc332vlu.1 
ENSMUST00000270710.1 Gm56825 ENSMUST00000270710.1 Gm56825 (from geneSymbol) uc332vlv.1 uc332vlv.1 
ENSMUST00000270713.1 ENSMUSG00000125541 ENSMUST00000270713.1 ENSMUSG00000125541 (from geneSymbol) uc332vly.1 uc332vly.1 
ENSMUST00000270715.1 ENSMUSG00000121489 ENSMUST00000270715.1 ENSMUSG00000121489 (from geneSymbol) AK017634 uc332vma.1 uc332vma.1 
ENSMUST00000270726.1 ENSMUSG00000125542 ENSMUST00000270726.1 ENSMUSG00000125542 (from geneSymbol) uc332vml.1 uc332vml.1 
ENSMUST00000270728.1 ENSMUSG00000125543 ENSMUST00000270728.1 ENSMUSG00000125543 (from geneSymbol) uc332vmn.1 uc332vmn.1 
ENSMUST00000270747.1 ENSMUSG00000125544 ENSMUST00000270747.1 ENSMUSG00000125544 (from geneSymbol) uc332vng.1 uc332vng.1 
ENSMUST00000270748.1 ENSMUSG00000125545 ENSMUST00000270748.1 ENSMUSG00000125545 (from geneSymbol) uc332vnh.1 uc332vnh.1 
ENSMUST00000270749.1 ENSMUSG00000125546 ENSMUST00000270749.1 ENSMUSG00000125546 (from geneSymbol) uc332vni.1 uc332vni.1 
ENSMUST00000270751.1 ENSMUSG00000125547 ENSMUST00000270751.1 ENSMUSG00000125547 (from geneSymbol) uc332vnk.1 uc332vnk.1 
ENSMUST00000270756.1 ENSMUSG00000125548 ENSMUST00000270756.1 ENSMUSG00000125548 (from geneSymbol) uc332vno.1 uc332vno.1 
ENSMUST00000270759.1 ENSMUSG00000125549 ENSMUST00000270759.1 ENSMUSG00000125549 (from geneSymbol) uc332vnq.1 uc332vnq.1 
ENSMUST00000270761.1 ENSMUSG00000125550 ENSMUST00000270761.1 ENSMUSG00000125550 (from geneSymbol) uc332vns.1 uc332vns.1 
ENSMUST00000270763.1 ENSMUSG00000125551 ENSMUST00000270763.1 ENSMUSG00000125551 (from geneSymbol) uc332vnu.1 uc332vnu.1 
ENSMUST00000270764.1 ENSMUSG00000125552 ENSMUST00000270764.1 ENSMUSG00000125552 (from geneSymbol) uc332vnv.1 uc332vnv.1 
ENSMUST00000270848.1 ENSMUSG00000125553 ENSMUST00000270848.1 ENSMUSG00000125553 (from geneSymbol) uc332vqp.1 uc332vqp.1 
ENSMUST00000270849.1 ENSMUSG00000125554 ENSMUST00000270849.1 ENSMUSG00000125554 (from geneSymbol) uc332vqq.1 uc332vqq.1 
ENSMUST00000270851.1 ENSMUSG00000125555 ENSMUST00000270851.1 ENSMUSG00000125555 (from geneSymbol) uc332vqs.1 uc332vqs.1 
ENSMUST00000270853.1 ENSMUSG00000125556 ENSMUST00000270853.1 ENSMUSG00000125556 (from geneSymbol) uc332vqu.1 uc332vqu.1 
ENSMUST00000270866.1 Gm29865 ENSMUST00000270866.1 Gm29865 (from geneSymbol) AK076734 uc332vrh.1 uc332vrh.1 
ENSMUST00000270889.1 Gm13270 ENSMUST00000270889.1 Gm13270 (from geneSymbol) AK035306 uc332vse.1 uc332vse.1 
ENSMUST00000270903.1 ENSMUSG00000125557 ENSMUST00000270903.1 ENSMUSG00000125557 (from geneSymbol) uc332vss.1 uc332vss.1 
ENSMUST00000270905.1 Gm15904 ENSMUST00000270905.1 Gm15904 (from geneSymbol) uc332vsu.1 uc332vsu.1 
ENSMUST00000270912.1 ENSMUSG00000125558 ENSMUST00000270912.1 ENSMUSG00000125558 (from geneSymbol) uc332vtb.1 uc332vtb.1 
ENSMUST00000270926.1 4930557F10Rik ENSMUST00000270926.1 4930557F10Rik (from geneSymbol) AK016161 uc332vtp.1 uc332vtp.1 
ENSMUST00000270951.1 ENSMUSG00000125559 ENSMUST00000270951.1 ENSMUSG00000125559 (from geneSymbol) uc332vuo.1 uc332vuo.1 
ENSMUST00000270952.1 ENSMUSG00000125560 ENSMUST00000270952.1 ENSMUSG00000125560 (from geneSymbol) uc332vup.1 uc332vup.1 
ENSMUST00000270953.1 ENSMUSG00000125561 ENSMUST00000270953.1 ENSMUSG00000125561 (from geneSymbol) uc332vuq.1 uc332vuq.1 
ENSMUST00000270956.1 ENSMUSG00000125562 ENSMUST00000270956.1 ENSMUSG00000125562 (from geneSymbol) uc332vut.1 uc332vut.1 
ENSMUST00000270963.1 Gm41077 ENSMUST00000270963.1 Gm41077 (from geneSymbol) uc332vva.1 uc332vva.1 
ENSMUST00000270976.1 ENSMUSG00000125563 ENSMUST00000270976.1 ENSMUSG00000125563 (from geneSymbol) uc332vvn.1 uc332vvn.1 
ENSMUST00000270977.1 ENSMUSG00000125564 ENSMUST00000270977.1 ENSMUSG00000125564 (from geneSymbol) uc332vvo.1 uc332vvo.1 
ENSMUST00000270979.1 ENSMUSG00000125565 ENSMUST00000270979.1 ENSMUSG00000125565 (from geneSymbol) uc332vvq.1 uc332vvq.1 
ENSMUST00000270982.1 ENSMUSG00000125566 ENSMUST00000270982.1 ENSMUSG00000125566 (from geneSymbol) uc332vvt.1 uc332vvt.1 
ENSMUST00000270983.1 ENSMUSG00000125567 ENSMUST00000270983.1 ENSMUSG00000125567 (from geneSymbol) uc332vvu.1 uc332vvu.1 
ENSMUST00000270984.1 ENSMUSG00000125568 ENSMUST00000270984.1 ENSMUSG00000125568 (from geneSymbol) uc332vvv.1 uc332vvv.1 
ENSMUST00000270994.1 Gm11520 ENSMUST00000270994.1 Gm11520 (from geneSymbol) KY467608 uc332vwf.1 uc332vwf.1 
ENSMUST00000271015.1 ENSMUSG00000125569 ENSMUST00000271015.1 ENSMUSG00000125569 (from geneSymbol) uc332vxa.1 uc332vxa.1 
ENSMUST00000271016.1 ENSMUSG00000125570 ENSMUST00000271016.1 ENSMUSG00000125570 (from geneSymbol) uc332vxb.1 uc332vxb.1 
ENSMUST00000271017.1 ENSMUSG00000125571 ENSMUST00000271017.1 ENSMUSG00000125571 (from geneSymbol) uc332vxc.1 uc332vxc.1 
ENSMUST00000271018.1 1700109G14Rik ENSMUST00000271018.1 1700109G14Rik (from geneSymbol) AK007149 uc332vxd.1 uc332vxd.1 
ENSMUST00000271031.1 ENSMUSG00000125572 ENSMUST00000271031.1 ENSMUSG00000125572 (from geneSymbol) uc332vxq.1 uc332vxq.1 
ENSMUST00000271037.1 ENSMUSG00000125573 ENSMUST00000271037.1 ENSMUSG00000125573 (from geneSymbol) uc332vxw.1 uc332vxw.1 
ENSMUST00000271044.1 Gm40383 ENSMUST00000271044.1 Gm40383 (from geneSymbol) uc332vyd.1 uc332vyd.1 
ENSMUST00000271052.1 ENSMUSG00000125574 ENSMUST00000271052.1 ENSMUSG00000125574 (from geneSymbol) LF201038 uc332vyl.1 uc332vyl.1 
ENSMUST00000271053.1 ENSMUSG00000125575 ENSMUST00000271053.1 ENSMUSG00000125575 (from geneSymbol) uc332vym.1 uc332vym.1 
ENSMUST00000271059.1 ENSMUSG00000125576 ENSMUST00000271059.1 ENSMUSG00000125576 (from geneSymbol) uc332vys.1 uc332vys.1 
ENSMUST00000271070.1 ENSMUSG00000125577 ENSMUST00000271070.1 ENSMUSG00000125577 (from geneSymbol) uc332vzd.1 uc332vzd.1 
ENSMUST00000271088.1 ENSMUSG00000125578 ENSMUST00000271088.1 ENSMUSG00000125578 (from geneSymbol) uc332vzv.1 uc332vzv.1 
ENSMUST00000271092.1 ENSMUSG00000125579 ENSMUST00000271092.1 ENSMUSG00000125579 (from geneSymbol) uc332vzz.1 uc332vzz.1 
ENSMUST00000271094.1 1810044D09Rik ENSMUST00000271094.1 1810044D09Rik (from geneSymbol) KY468097 uc332wab.1 uc332wab.1 
ENSMUST00000271098.1 ENSMUSG00000125580 ENSMUST00000271098.1 ENSMUSG00000125580 (from geneSymbol) uc332waf.1 uc332waf.1 
ENSMUST00000271105.1 ENSMUSG00000125581 ENSMUST00000271105.1 ENSMUSG00000125581 (from geneSymbol) uc332wam.1 uc332wam.1 
ENSMUST00000271120.1 ENSMUSG00000125582 ENSMUST00000271120.1 ENSMUSG00000125582 (from geneSymbol) uc332wbb.1 uc332wbb.1 
ENSMUST00000271121.1 Gm44899 ENSMUST00000271121.1 Gm44899 (from geneSymbol) uc332wbc.1 uc332wbc.1 
ENSMUST00000271122.1 ENSMUSG00000125583 ENSMUST00000271122.1 ENSMUSG00000125583 (from geneSymbol) uc332wbd.1 uc332wbd.1 
ENSMUST00000271124.1 ENSMUSG00000125584 ENSMUST00000271124.1 ENSMUSG00000125584 (from geneSymbol) uc332wbf.1 uc332wbf.1 
ENSMUST00000271125.1 ENSMUSG00000125585 ENSMUST00000271125.1 ENSMUSG00000125585 (from geneSymbol) uc332wbg.1 uc332wbg.1 
ENSMUST00000271126.1 ENSMUSG00000125586 ENSMUST00000271126.1 ENSMUSG00000125586 (from geneSymbol) uc332wbh.1 uc332wbh.1 
ENSMUST00000271129.1 ENSMUSG00000125587 ENSMUST00000271129.1 ENSMUSG00000125587 (from geneSymbol) uc332wbk.1 uc332wbk.1 
ENSMUST00000271131.1 ENSMUSG00000125588 ENSMUST00000271131.1 ENSMUSG00000125588 (from geneSymbol) uc332wbm.1 uc332wbm.1 
ENSMUST00000271132.1 ENSMUSG00000125589 ENSMUST00000271132.1 ENSMUSG00000125589 (from geneSymbol) uc332wbn.1 uc332wbn.1 
ENSMUST00000271133.1 ENSMUSG00000125590 ENSMUST00000271133.1 ENSMUSG00000125590 (from geneSymbol) uc332wbo.1 uc332wbo.1 
ENSMUST00000271134.1 ENSMUSG00000125591 ENSMUST00000271134.1 ENSMUSG00000125591 (from geneSymbol) uc332wbp.1 uc332wbp.1 
ENSMUST00000271135.1 ENSMUSG00000125592 ENSMUST00000271135.1 ENSMUSG00000125592 (from geneSymbol) uc332wbq.1 uc332wbq.1 
ENSMUST00000271136.1 ENSMUSG00000125593 ENSMUST00000271136.1 ENSMUSG00000125593 (from geneSymbol) uc332wbr.1 uc332wbr.1 
ENSMUST00000271137.1 ENSMUSG00000125594 ENSMUST00000271137.1 ENSMUSG00000125594 (from geneSymbol) uc332wbs.1 uc332wbs.1 
ENSMUST00000271141.1 2310040G24Rik ENSMUST00000271141.1 2310040G24Rik (from geneSymbol) uc332wbw.1 uc332wbw.1 
ENSMUST00000271156.1 ENSMUSG00000125595 ENSMUST00000271156.1 ENSMUSG00000125595 (from geneSymbol) uc332wcl.1 uc332wcl.1 
ENSMUST00000271157.1 ENSMUSG00000125596 ENSMUST00000271157.1 ENSMUSG00000125596 (from geneSymbol) uc332wcm.1 uc332wcm.1 
ENSMUST00000271158.1 ENSMUSG00000125597 ENSMUST00000271158.1 ENSMUSG00000125597 (from geneSymbol) uc332wcn.1 uc332wcn.1 
ENSMUST00000271160.1 Gm38505 ENSMUST00000271160.1 Gm38505 (from geneSymbol) uc332wcp.1 uc332wcp.1 
ENSMUST00000271196.1 ENSMUSG00000125598 ENSMUST00000271196.1 ENSMUSG00000125598 (from geneSymbol) uc332wdz.1 uc332wdz.1 
ENSMUST00000271198.1 ENSMUSG00000125599 ENSMUST00000271198.1 ENSMUSG00000125599 (from geneSymbol) uc332web.1 uc332web.1 
ENSMUST00000271205.1 ENSMUSG00000125600 ENSMUST00000271205.1 ENSMUSG00000125600 (from geneSymbol) uc332wei.1 uc332wei.1 
ENSMUST00000271210.1 ENSMUSG00000125601 ENSMUST00000271210.1 ENSMUSG00000125601 (from geneSymbol) uc332wen.1 uc332wen.1 
ENSMUST00000271213.1 ENSMUSG00000125602 ENSMUST00000271213.1 ENSMUSG00000125602 (from geneSymbol) uc332weq.1 uc332weq.1 
ENSMUST00000271214.1 ENSMUSG00000125603 ENSMUST00000271214.1 ENSMUSG00000125603 (from geneSymbol) uc332wer.1 uc332wer.1 
ENSMUST00000271216.1 ENSMUSG00000125604 ENSMUST00000271216.1 ENSMUSG00000125604 (from geneSymbol) uc332wet.1 uc332wet.1 
ENSMUST00000271219.1 ENSMUSG00000125605 ENSMUST00000271219.1 ENSMUSG00000125605 (from geneSymbol) uc332wew.1 uc332wew.1 
ENSMUST00000271220.1 ENSMUSG00000125606 ENSMUST00000271220.1 ENSMUSG00000125606 (from geneSymbol) uc332wex.1 uc332wex.1 
ENSMUST00000271227.1 ENSMUSG00000125607 ENSMUST00000271227.1 ENSMUSG00000125607 (from geneSymbol) uc332wfe.1 uc332wfe.1 
ENSMUST00000271230.1 ENSMUSG00000125608 ENSMUST00000271230.1 ENSMUSG00000125608 (from geneSymbol) uc332wfg.1 uc332wfg.1 
ENSMUST00000271233.1 ENSMUSG00000125609 ENSMUST00000271233.1 ENSMUSG00000125609 (from geneSymbol) uc332wfj.1 uc332wfj.1 
ENSMUST00000271236.1 ENSMUSG00000125610 ENSMUST00000271236.1 ENSMUSG00000125610 (from geneSymbol) uc332wfm.1 uc332wfm.1 
ENSMUST00000271275.1 ENSMUSG00000125611 ENSMUST00000271275.1 ENSMUSG00000125611 (from geneSymbol) uc332wgz.1 uc332wgz.1 
ENSMUST00000271285.1 ENSMUSG00000125612 ENSMUST00000271285.1 ENSMUSG00000125612 (from geneSymbol) uc332whj.1 uc332whj.1 
ENSMUST00000271286.1 ENSMUSG00000125613 ENSMUST00000271286.1 ENSMUSG00000125613 (from geneSymbol) uc332whk.1 uc332whk.1 
ENSMUST00000271287.1 ENSMUSG00000125614 ENSMUST00000271287.1 ENSMUSG00000125614 (from geneSymbol) uc332whl.1 uc332whl.1 
ENSMUST00000271297.1 Gm48716 ENSMUST00000271297.1 Gm48716 (from geneSymbol) uc332whs.1 uc332whs.1 
ENSMUST00000271298.1 ENSMUSG00000125615 ENSMUST00000271298.1 ENSMUSG00000125615 (from geneSymbol) uc332wht.1 uc332wht.1 
ENSMUST00000271299.1 ENSMUSG00000125616 ENSMUST00000271299.1 ENSMUSG00000125616 (from geneSymbol) uc332whu.1 uc332whu.1 
ENSMUST00000271300.1 ENSMUSG00000125617 ENSMUST00000271300.1 ENSMUSG00000125617 (from geneSymbol) uc332whv.1 uc332whv.1 
ENSMUST00000271303.1 ENSMUSG00000125618 ENSMUST00000271303.1 ENSMUSG00000125618 (from geneSymbol) uc332why.1 uc332why.1 
ENSMUST00000271305.1 ENSMUSG00000125619 ENSMUST00000271305.1 ENSMUSG00000125619 (from geneSymbol) uc332wia.1 uc332wia.1 
ENSMUST00000271306.1 ENSMUSG00000125620 ENSMUST00000271306.1 ENSMUSG00000125620 (from geneSymbol) uc332wib.1 uc332wib.1 
ENSMUST00000271307.1 4930471M09Rik ENSMUST00000271307.1 4930471M09Rik (from geneSymbol) AK015554 uc332wic.1 uc332wic.1 
ENSMUST00000271314.1 ENSMUSG00000125621 ENSMUST00000271314.1 ENSMUSG00000125621 (from geneSymbol) uc332wij.1 uc332wij.1 
ENSMUST00000271321.1 Gm48393 ENSMUST00000271321.1 Gm48393 (from geneSymbol) uc332wiq.1 uc332wiq.1 
ENSMUST00000271328.1 ENSMUSG00000125622 ENSMUST00000271328.1 ENSMUSG00000125622 (from geneSymbol) uc332wix.1 uc332wix.1 
ENSMUST00000271336.1 ENSMUSG00000125623 ENSMUST00000271336.1 ENSMUSG00000125623 (from geneSymbol) uc332wjf.1 uc332wjf.1 
ENSMUST00000271341.1 4930535O05Rik ENSMUST00000271341.1 RIKEN cDNA 4930535O05 gene (from RefSeq NR_166505.1) NR_166505 uc332wjk.1 uc332wjk.1 
ENSMUST00000271346.1 ENSMUSG00000125624 ENSMUST00000271346.1 ENSMUSG00000125624 (from geneSymbol) uc332wjp.1 uc332wjp.1 
ENSMUST00000271356.1 ENSMUSG00000125625 ENSMUST00000271356.1 ENSMUSG00000125625 (from geneSymbol) uc332wjz.1 uc332wjz.1 
ENSMUST00000271357.1 ENSMUSG00000125626 ENSMUST00000271357.1 ENSMUSG00000125626 (from geneSymbol) uc332wka.1 uc332wka.1 
ENSMUST00000271358.1 Gm33474 ENSMUST00000271358.1 Gm33474 (from geneSymbol) AK143409 uc332wkb.1 uc332wkb.1 
ENSMUST00000271385.1 4930535E02Rik ENSMUST00000271385.1 4930535E02Rik (from geneSymbol) AK015977 uc332wlc.1 uc332wlc.1 
ENSMUST00000271389.1 ENSMUSG00000125627 ENSMUST00000271389.1 ENSMUSG00000125627 (from geneSymbol) uc332wlg.1 uc332wlg.1 
ENSMUST00000271394.1 ENSMUSG00000125628 ENSMUST00000271394.1 ENSMUSG00000125628 (from geneSymbol) uc332wll.1 uc332wll.1 
ENSMUST00000271396.1 ENSMUSG00000125630 ENSMUST00000271396.1 ENSMUSG00000125630 (from geneSymbol) uc332wlm.1 uc332wlm.1 
ENSMUST00000271398.1 ENSMUSG00000125631 ENSMUST00000271398.1 ENSMUSG00000125631 (from geneSymbol) uc332wlo.1 uc332wlo.1 
ENSMUST00000271412.1 ENSMUSG00000125632 ENSMUST00000271412.1 ENSMUSG00000125632 (from geneSymbol) uc332wmc.1 uc332wmc.1 
ENSMUST00000271424.1 ENSMUSG00000125633 ENSMUST00000271424.1 ENSMUSG00000125633 (from geneSymbol) uc332wmn.1 uc332wmn.1 
ENSMUST00000271425.1 ENSMUSG00000125634 ENSMUST00000271425.1 ENSMUSG00000125634 (from geneSymbol) uc332wmo.1 uc332wmo.1 
ENSMUST00000271426.1 ENSMUSG00000125635 ENSMUST00000271426.1 ENSMUSG00000125635 (from geneSymbol) uc332wmp.1 uc332wmp.1 
ENSMUST00000271433.1 ENSMUSG00000125636 ENSMUST00000271433.1 ENSMUSG00000125636 (from geneSymbol) uc332wmw.1 uc332wmw.1 
ENSMUST00000271434.1 ENSMUSG00000125637 ENSMUST00000271434.1 ENSMUSG00000125637 (from geneSymbol) uc332wmx.1 uc332wmx.1 
ENSMUST00000271435.1 ENSMUSG00000125638 ENSMUST00000271435.1 ENSMUSG00000125638 (from geneSymbol) uc332wmy.1 uc332wmy.1 
ENSMUST00000271436.1 ENSMUSG00000125639 ENSMUST00000271436.1 ENSMUSG00000125639 (from geneSymbol) uc332wmz.1 uc332wmz.1 
ENSMUST00000271437.1 ENSMUSG00000125640 ENSMUST00000271437.1 ENSMUSG00000125640 (from geneSymbol) uc332wna.1 uc332wna.1 
ENSMUST00000271439.1 Gm57284 ENSMUST00000271439.1 Gm57284 (from geneSymbol) uc332wnc.1 uc332wnc.1 
ENSMUST00000271441.1 Gm42695 ENSMUST00000271441.1 Gm42695 (from geneSymbol) AK080448 uc332wne.1 uc332wne.1 
ENSMUST00000271446.1 ENSMUSG00000125641 ENSMUST00000271446.1 ENSMUSG00000125641 (from geneSymbol) uc332wnj.1 uc332wnj.1 
ENSMUST00000271448.1 Leat1 ENSMUST00000271448.1 Leat1 (from geneSymbol) AK041443 uc332wnl.1 uc332wnl.1 
ENSMUST00000271450.1 ENSMUSG00000125642 ENSMUST00000271450.1 ENSMUSG00000125642 (from geneSymbol) uc332wnn.1 uc332wnn.1 
ENSMUST00000271460.1 ENSMUSG00000125643 ENSMUST00000271460.1 ENSMUSG00000125643 (from geneSymbol) uc332wnx.1 uc332wnx.1 
ENSMUST00000271466.1 Gm39329 ENSMUST00000271466.1 Gm39329 (from geneSymbol) AK135600 uc332wod.1 uc332wod.1 
ENSMUST00000271468.1 ENSMUSG00000125644 ENSMUST00000271468.1 ENSMUSG00000125644 (from geneSymbol) uc332wof.1 uc332wof.1 
ENSMUST00000271470.1 ENSMUSG00000125645 ENSMUST00000271470.1 ENSMUSG00000125645 (from geneSymbol) uc332woh.1 uc332woh.1 
ENSMUST00000271474.1 ENSMUSG00000125646 ENSMUST00000271474.1 ENSMUSG00000125646 (from geneSymbol) uc332wol.1 uc332wol.1 
ENSMUST00000271478.1 ENSMUSG00000125647 ENSMUST00000271478.1 ENSMUSG00000125647 (from geneSymbol) uc332wop.1 uc332wop.1 
ENSMUST00000271479.1 ENSMUSG00000125648 ENSMUST00000271479.1 ENSMUSG00000125648 (from geneSymbol) AK136897 uc332woq.1 uc332woq.1 
ENSMUST00000271489.1 ENSMUSG00000125649 ENSMUST00000271489.1 ENSMUSG00000125649 (from geneSymbol) uc332wpa.1 uc332wpa.1 
ENSMUST00000271491.1 Gm16525 ENSMUST00000271491.1 predicted gene, 16525, transcript variant 3 (from RefSeq NR_169099.1) NR_169099 uc332wpc.1 uc332wpc.1 
ENSMUST00000271498.1 Gm36235 ENSMUST00000271498.1 Gm36235 (from geneSymbol) AF230110 uc332wpj.1 uc332wpj.1 
ENSMUST00000271504.1 ENSMUSG00000125651 ENSMUST00000271504.1 ENSMUSG00000125651 (from geneSymbol) uc332wpp.1 uc332wpp.1 
ENSMUST00000271505.1 ENSMUSG00000125652 ENSMUST00000271505.1 ENSMUSG00000125652 (from geneSymbol) uc332wpq.1 uc332wpq.1 
ENSMUST00000271506.1 ENSMUSG00000125653 ENSMUST00000271506.1 ENSMUSG00000125653 (from geneSymbol) uc332wpr.1 uc332wpr.1 
ENSMUST00000271507.1 ENSMUSG00000125654 ENSMUST00000271507.1 ENSMUSG00000125654 (from geneSymbol) uc332wps.1 uc332wps.1 
ENSMUST00000271508.1 ENSMUSG00000125655 ENSMUST00000271508.1 ENSMUSG00000125655 (from geneSymbol) uc332wpt.1 uc332wpt.1 
ENSMUST00000271509.1 ENSMUSG00000125656 ENSMUST00000271509.1 ENSMUSG00000125656 (from geneSymbol) uc332wpu.1 uc332wpu.1 
ENSMUST00000271512.1 Gm47267 ENSMUST00000271512.1 Gm47267 (from geneSymbol) uc332wpx.1 uc332wpx.1 
ENSMUST00000271514.1 ENSMUSG00000125657 ENSMUST00000271514.1 ENSMUSG00000125657 (from geneSymbol) uc332wpz.1 uc332wpz.1 
ENSMUST00000271515.1 ENSMUSG00000125658 ENSMUST00000271515.1 ENSMUSG00000125658 (from geneSymbol) uc332wqa.1 uc332wqa.1 
ENSMUST00000271517.1 ENSMUSG00000125659 ENSMUST00000271517.1 ENSMUSG00000125659 (from geneSymbol) uc332wqc.1 uc332wqc.1 
ENSMUST00000271519.1 Gm32772 ENSMUST00000271519.1 Gm32772 (from geneSymbol) AK132898 uc332wqe.1 uc332wqe.1 
ENSMUST00000271552.1 ENSMUSG00000125660 ENSMUST00000271552.1 ENSMUSG00000125660 (from geneSymbol) uc332wrl.1 uc332wrl.1 
ENSMUST00000271554.1 ENSMUSG00000125661 ENSMUST00000271554.1 ENSMUSG00000125661 (from geneSymbol) uc332wrn.1 uc332wrn.1 
ENSMUST00000271561.1 ENSMUSG00000125662 ENSMUST00000271561.1 ENSMUSG00000125662 (from geneSymbol) uc332wru.1 uc332wru.1 
ENSMUST00000271562.1 Gm34333 ENSMUST00000271562.1 Gm34333 (from geneSymbol) uc332wrv.1 uc332wrv.1 
ENSMUST00000271566.1 Gm32219 ENSMUST00000271566.1 Gm32219 (from geneSymbol) uc332wrz.1 uc332wrz.1 
ENSMUST00000271580.1 Gm6938 ENSMUST00000271580.1 Gm6938 (from geneSymbol) uc332wsn.1 uc332wsn.1 
ENSMUST00000271585.1 A230045G11Rik ENSMUST00000271585.1 A230045G11Rik (from geneSymbol) AK133970 uc332wss.1 uc332wss.1 
ENSMUST00000271595.1 ENSMUSG00000125663 ENSMUST00000271595.1 ENSMUSG00000125663 (from geneSymbol) uc332wtc.1 uc332wtc.1 
ENSMUST00000271598.1 ENSMUSG00000125664 ENSMUST00000271598.1 ENSMUSG00000125664 (from geneSymbol) uc332wtf.1 uc332wtf.1 
ENSMUST00000271599.1 ENSMUSG00000125665 ENSMUST00000271599.1 ENSMUSG00000125665 (from geneSymbol) uc332wtg.1 uc332wtg.1 
ENSMUST00000271602.1 ENSMUSG00000125666 ENSMUST00000271602.1 ENSMUSG00000125666 (from geneSymbol) uc332wtj.1 uc332wtj.1 
ENSMUST00000271603.1 ENSMUSG00000125667 ENSMUST00000271603.1 ENSMUSG00000125667 (from geneSymbol) uc332wtk.1 uc332wtk.1 
ENSMUST00000271605.1 ENSMUSG00000125668 ENSMUST00000271605.1 ENSMUSG00000125668 (from geneSymbol) uc332wtm.1 uc332wtm.1 
ENSMUST00000271606.1 ENSMUSG00000125669 ENSMUST00000271606.1 ENSMUSG00000125669 (from geneSymbol) AK206798 uc332wtn.1 uc332wtn.1 
ENSMUST00000271613.1 ENSMUSG00000125670 ENSMUST00000271613.1 ENSMUSG00000125670 (from geneSymbol) uc332wtu.1 uc332wtu.1 
ENSMUST00000271615.1 ENSMUSG00000125671 ENSMUST00000271615.1 ENSMUSG00000125671 (from geneSymbol) uc332wtw.1 uc332wtw.1 
ENSMUST00000271616.1 ENSMUSG00000125672 ENSMUST00000271616.1 ENSMUSG00000125672 (from geneSymbol) uc332wtx.1 uc332wtx.1 
ENSMUST00000271634.1 ENSMUSG00000125673 ENSMUST00000271634.1 ENSMUSG00000125673 (from geneSymbol) uc332wup.1 uc332wup.1 
ENSMUST00000271645.1 ENSMUSG00000125674 ENSMUST00000271645.1 ENSMUSG00000125674 (from geneSymbol) uc332wva.1 uc332wva.1 
ENSMUST00000271667.1 ENSMUSG00000125675 ENSMUST00000271667.1 ENSMUSG00000125675 (from geneSymbol) uc332wvw.1 uc332wvw.1 
ENSMUST00000271668.1 Zfp286os ENSMUST00000271668.1 Zfp286os (from geneSymbol) uc332wvx.1 uc332wvx.1 
ENSMUST00000271677.1 4933440M02Rik ENSMUST00000271677.1 4933440M02Rik (from geneSymbol) AK031079 uc332wwg.1 uc332wwg.1 
ENSMUST00000271758.1 ENSMUSG00000125676 ENSMUST00000271758.1 ENSMUSG00000125676 (from geneSymbol) uc332wzj.1 uc332wzj.1 
ENSMUST00000271789.1 ENSMUSG00000125678 ENSMUST00000271789.1 ENSMUSG00000125678 (from geneSymbol) uc332xan.1 uc332xan.1 
ENSMUST00000271791.1 ENSMUSG00000125679 ENSMUST00000271791.1 ENSMUSG00000125679 (from geneSymbol) uc332xap.1 uc332xap.1 
ENSMUST00000271793.1 ENSMUSG00000125680 ENSMUST00000271793.1 ENSMUSG00000125680 (from geneSymbol) uc332xar.1 uc332xar.1 
ENSMUST00000271794.1 ENSMUSG00000125681 ENSMUST00000271794.1 ENSMUSG00000125681 (from geneSymbol) uc332xas.1 uc332xas.1 
ENSMUST00000271796.1 ENSMUSG00000125682 ENSMUST00000271796.1 ENSMUSG00000125682 (from geneSymbol) uc332xau.1 uc332xau.1 
ENSMUST00000271800.1 ENSMUSG00000125683 ENSMUST00000271800.1 ENSMUSG00000125683 (from geneSymbol) uc332xay.1 uc332xay.1 
ENSMUST00000271801.1 ENSMUSG00000125684 ENSMUST00000271801.1 ENSMUSG00000125684 (from geneSymbol) uc332xaz.1 uc332xaz.1 
ENSMUST00000271802.1 ENSMUSG00000125685 ENSMUST00000271802.1 ENSMUSG00000125685 (from geneSymbol) uc332xba.1 uc332xba.1 
ENSMUST00000271803.1 ENSMUSG00000125686 ENSMUST00000271803.1 ENSMUSG00000125686 (from geneSymbol) uc332xbb.1 uc332xbb.1 
ENSMUST00000271808.1 ENSMUSG00000125687 ENSMUST00000271808.1 ENSMUSG00000125687 (from geneSymbol) uc332xbg.1 uc332xbg.1 
ENSMUST00000271809.1 ENSMUSG00000125688 ENSMUST00000271809.1 ENSMUSG00000125688 (from geneSymbol) uc332xbh.1 uc332xbh.1 
ENSMUST00000271811.1 ENSMUSG00000125689 ENSMUST00000271811.1 ENSMUSG00000125689 (from geneSymbol) uc332xbj.1 uc332xbj.1 
ENSMUST00000271814.1 ENSMUSG00000125690 ENSMUST00000271814.1 ENSMUSG00000125690 (from geneSymbol) uc332xbm.1 uc332xbm.1 
ENSMUST00000271817.1 ENSMUSG00000125691 ENSMUST00000271817.1 ENSMUSG00000125691 (from geneSymbol) uc332xbp.1 uc332xbp.1 
ENSMUST00000271818.1 ENSMUSG00000125692 ENSMUST00000271818.1 ENSMUSG00000125692 (from geneSymbol) uc332xbq.1 uc332xbq.1 
ENSMUST00000271820.1 Gm29521 ENSMUST00000271820.1 Gm29521 (from geneSymbol) AK043163 uc332xbs.1 uc332xbs.1 
ENSMUST00000271824.1 ENSMUSG00000125693 ENSMUST00000271824.1 ENSMUSG00000125693 (from geneSymbol) uc332xbw.1 uc332xbw.1 
ENSMUST00000271826.1 Gm13564 ENSMUST00000271826.1 Gm13564 (from geneSymbol) uc332xby.1 uc332xby.1 
ENSMUST00000271830.1 ENSMUSG00000125694 ENSMUST00000271830.1 ENSMUSG00000125694 (from geneSymbol) uc332xcc.1 uc332xcc.1 
ENSMUST00000271832.1 Gm10570 ENSMUST00000271832.1 Gm10570 (from geneSymbol) uc332xce.1 uc332xce.1 
ENSMUST00000271837.1 1700060J05Rik ENSMUST00000271837.1 1700060J05Rik (from geneSymbol) AK006843 uc332xcj.1 uc332xcj.1 
ENSMUST00000271840.1 ENSMUSG00000121352 ENSMUST00000271840.1 ENSMUSG00000121352 (from geneSymbol) AK137448 uc332xcm.1 uc332xcm.1 
ENSMUST00000271848.1 ENSMUSG00000125695 ENSMUST00000271848.1 ENSMUSG00000125695 (from geneSymbol) uc332xcu.1 uc332xcu.1 
ENSMUST00000271850.1 Gm35772 ENSMUST00000271850.1 Gm35772 (from geneSymbol) uc332xcw.1 uc332xcw.1 
ENSMUST00000271856.1 ENSMUSG00000125696 ENSMUST00000271856.1 ENSMUSG00000125696 (from geneSymbol) uc332xdc.1 uc332xdc.1 
ENSMUST00000271869.1 ENSMUSG00000125697 ENSMUST00000271869.1 ENSMUSG00000125697 (from geneSymbol) uc332xdp.1 uc332xdp.1 
ENSMUST00000271879.1 ENSMUSG00000125698 ENSMUST00000271879.1 ENSMUSG00000125698 (from geneSymbol) uc332xdz.1 uc332xdz.1 
ENSMUST00000271880.1 ENSMUSG00000125699 ENSMUST00000271880.1 ENSMUSG00000125699 (from geneSymbol) uc332xea.1 uc332xea.1 
ENSMUST00000271898.1 ENSMUSG00000125700 ENSMUST00000271898.1 ENSMUSG00000125700 (from geneSymbol) uc332xes.1 uc332xes.1 
ENSMUST00000271910.1 ENSMUSG00000125701 ENSMUST00000271910.1 ENSMUSG00000125701 (from geneSymbol) uc332xfe.1 uc332xfe.1 
ENSMUST00000271912.1 ENSMUSG00000125702 ENSMUST00000271912.1 ENSMUSG00000125702 (from geneSymbol) uc332xfg.1 uc332xfg.1 
ENSMUST00000271914.1 ENSMUSG00000125703 ENSMUST00000271914.1 ENSMUSG00000125703 (from geneSymbol) uc332xfi.1 uc332xfi.1 
ENSMUST00000271915.1 ENSMUSG00000125704 ENSMUST00000271915.1 ENSMUSG00000125704 (from geneSymbol) uc332xfj.1 uc332xfj.1 
ENSMUST00000271916.1 ENSMUSG00000125705 ENSMUST00000271916.1 ENSMUSG00000125705 (from geneSymbol) uc332xfk.1 uc332xfk.1 
ENSMUST00000271918.1 ENSMUSG00000125706 ENSMUST00000271918.1 ENSMUSG00000125706 (from geneSymbol) uc332xfm.1 uc332xfm.1 
ENSMUST00000271919.1 ENSMUSG00000125707 ENSMUST00000271919.1 ENSMUSG00000125707 (from geneSymbol) uc332xfn.1 uc332xfn.1 
ENSMUST00000271922.1 ENSMUSG00000125710 ENSMUST00000271922.1 ENSMUSG00000125710 (from geneSymbol) uc332xfo.1 uc332xfo.1 
ENSMUST00000271923.1 ENSMUSG00000125711 ENSMUST00000271923.1 ENSMUSG00000125711 (from geneSymbol) uc332xfp.1 uc332xfp.1 
ENSMUST00000271924.1 ENSMUSG00000125712 ENSMUST00000271924.1 ENSMUSG00000125712 (from geneSymbol) uc332xfq.1 uc332xfq.1 
ENSMUST00000271927.1 ENSMUSG00000125713 ENSMUST00000271927.1 ENSMUSG00000125713 (from geneSymbol) uc332xft.1 uc332xft.1 
ENSMUST00000271947.1 Gm49445 ENSMUST00000271947.1 Gm49445 (from geneSymbol) uc332xgm.1 uc332xgm.1 
ENSMUST00000271959.1 ENSMUSG00000125714 ENSMUST00000271959.1 ENSMUSG00000125714 (from geneSymbol) uc332xgy.1 uc332xgy.1 
ENSMUST00000271960.1 ENSMUSG00000125715 ENSMUST00000271960.1 ENSMUSG00000125715 (from geneSymbol) uc332xgz.1 uc332xgz.1 
ENSMUST00000271965.1 ENSMUSG00000125716 ENSMUST00000271965.1 ENSMUSG00000125716 (from geneSymbol) uc332xhe.1 uc332xhe.1 
ENSMUST00000271967.1 Gm14773 ENSMUST00000271967.1 Gm14773 (from geneSymbol) uc332xhg.1 uc332xhg.1 
ENSMUST00000271969.1 ENSMUSG00000125717 ENSMUST00000271969.1 ENSMUSG00000125717 (from geneSymbol) uc332xhi.1 uc332xhi.1 
ENSMUST00000271971.1 ENSMUSG00000125718 ENSMUST00000271971.1 ENSMUSG00000125718 (from geneSymbol) uc332xhk.1 uc332xhk.1 
ENSMUST00000271972.1 Gm44115 ENSMUST00000271972.1 Gm44115 (from geneSymbol) uc332xhl.1 uc332xhl.1 
ENSMUST00000271978.1 ENSMUSG00000125719 ENSMUST00000271978.1 ENSMUSG00000125719 (from geneSymbol) uc332xhr.1 uc332xhr.1 
ENSMUST00000271983.1 ENSMUSG00000125720 ENSMUST00000271983.1 ENSMUSG00000125720 (from geneSymbol) uc332xhw.1 uc332xhw.1 
ENSMUST00000271984.1 ENSMUSG00000125721 ENSMUST00000271984.1 ENSMUSG00000125721 (from geneSymbol) uc332xhx.1 uc332xhx.1 
ENSMUST00000271985.1 ENSMUSG00000125722 ENSMUST00000271985.1 ENSMUSG00000125722 (from geneSymbol) uc332xhy.1 uc332xhy.1 
ENSMUST00000271986.1 ENSMUSG00000125723 ENSMUST00000271986.1 ENSMUSG00000125723 (from geneSymbol) uc332xhz.1 uc332xhz.1 
ENSMUST00000271987.1 ENSMUSG00000125724 ENSMUST00000271987.1 ENSMUSG00000125724 (from geneSymbol) uc332xia.1 uc332xia.1 
ENSMUST00000271988.1 ENSMUSG00000125725 ENSMUST00000271988.1 ENSMUSG00000125725 (from geneSymbol) uc332xib.1 uc332xib.1 
ENSMUST00000271993.1 ENSMUSG00000125726 ENSMUST00000271993.1 ENSMUSG00000125726 (from geneSymbol) uc332xig.1 uc332xig.1 
ENSMUST00000271994.1 ENSMUSG00000125727 ENSMUST00000271994.1 ENSMUSG00000125727 (from geneSymbol) uc332xih.1 uc332xih.1 
ENSMUST00000271995.1 Gm13561 ENSMUST00000271995.1 Gm13561 (from geneSymbol) AK079054 uc332xii.1 uc332xii.1 
ENSMUST00000271996.1 ENSMUSG00000125728 ENSMUST00000271996.1 ENSMUSG00000125728 (from geneSymbol) uc332xij.1 uc332xij.1 
ENSMUST00000272002.1 ENSMUSG00000125729 ENSMUST00000272002.1 ENSMUSG00000125729 (from geneSymbol) uc332xip.1 uc332xip.1 
ENSMUST00000272008.1 ENSMUSG00000125730 ENSMUST00000272008.1 ENSMUSG00000125730 (from geneSymbol) uc332xiv.1 uc332xiv.1 
ENSMUST00000272012.1 ENSMUSG00000125731 ENSMUST00000272012.1 ENSMUSG00000125731 (from geneSymbol) uc332xiz.1 uc332xiz.1 
ENSMUST00000272013.1 ENSMUSG00000125732 ENSMUST00000272013.1 ENSMUSG00000125732 (from geneSymbol) uc332xja.1 uc332xja.1 
ENSMUST00000272023.1 ENSMUSG00000125733 ENSMUST00000272023.1 ENSMUSG00000125733 (from geneSymbol) uc332xjk.1 uc332xjk.1 
ENSMUST00000272029.1 ENSMUSG00000125734 ENSMUST00000272029.1 ENSMUSG00000125734 (from geneSymbol) uc332xjq.1 uc332xjq.1 
ENSMUST00000272032.1 ENSMUSG00000125735 ENSMUST00000272032.1 ENSMUSG00000125735 (from geneSymbol) uc332xjt.1 uc332xjt.1 
ENSMUST00000272033.1 ENSMUSG00000125736 ENSMUST00000272033.1 ENSMUSG00000125736 (from geneSymbol) uc332xju.1 uc332xju.1 
ENSMUST00000272036.1 ENSMUSG00000125737 ENSMUST00000272036.1 ENSMUSG00000125737 (from geneSymbol) uc332xjx.1 uc332xjx.1 
ENSMUST00000272039.1 ENSMUSG00000125738 ENSMUST00000272039.1 ENSMUSG00000125738 (from geneSymbol) uc332xka.1 uc332xka.1 
ENSMUST00000272042.1 ENSMUSG00000125739 ENSMUST00000272042.1 ENSMUSG00000125739 (from geneSymbol) uc332xkc.1 uc332xkc.1 
ENSMUST00000272043.1 ENSMUSG00000125740 ENSMUST00000272043.1 ENSMUSG00000125740 (from geneSymbol) uc332xkd.1 uc332xkd.1 
ENSMUST00000272045.1 ENSMUSG00000125741 ENSMUST00000272045.1 ENSMUSG00000125741 (from geneSymbol) uc332xkf.1 uc332xkf.1 
ENSMUST00000272046.1 ENSMUSG00000125742 ENSMUST00000272046.1 ENSMUSG00000125742 (from geneSymbol) uc332xkg.1 uc332xkg.1 
ENSMUST00000272047.1 ENSMUSG00000125743 ENSMUST00000272047.1 ENSMUSG00000125743 (from geneSymbol) uc332xkh.1 uc332xkh.1 
ENSMUST00000272053.1 ENSMUSG00000125745 ENSMUST00000272053.1 ENSMUSG00000125745 (from geneSymbol) uc332xkl.1 uc332xkl.1 
ENSMUST00000272054.1 ENSMUSG00000125746 ENSMUST00000272054.1 ENSMUSG00000125746 (from geneSymbol) uc332xkm.1 uc332xkm.1 
ENSMUST00000272072.1 Gm11731 ENSMUST00000272072.1 Gm11731 (from geneSymbol) uc332xle.1 uc332xle.1 
ENSMUST00000272077.1 ENSMUSG00000125747 ENSMUST00000272077.1 ENSMUSG00000125747 (from geneSymbol) uc332xlj.1 uc332xlj.1 
ENSMUST00000272079.1 ENSMUSG00000125748 ENSMUST00000272079.1 ENSMUSG00000125748 (from geneSymbol) uc332xll.1 uc332xll.1 
ENSMUST00000272082.1 ENSMUSG00000125749 ENSMUST00000272082.1 ENSMUSG00000125749 (from geneSymbol) uc332xln.1 uc332xln.1 
ENSMUST00000272094.1 Gm42205 ENSMUST00000272094.1 Gm42205 (from geneSymbol) uc332xlz.1 uc332xlz.1 
ENSMUST00000272099.1 ENSMUSG00000125750 ENSMUST00000272099.1 ENSMUSG00000125750 (from geneSymbol) uc332xme.1 uc332xme.1 
ENSMUST00000272105.1 ENSMUSG00000125751 ENSMUST00000272105.1 ENSMUSG00000125751 (from geneSymbol) uc332xmk.1 uc332xmk.1 
ENSMUST00000272106.1 ENSMUSG00000125752 ENSMUST00000272106.1 ENSMUSG00000125752 (from geneSymbol) uc332xml.1 uc332xml.1 
ENSMUST00000272109.1 ENSMUSG00000125753 ENSMUST00000272109.1 ENSMUSG00000125753 (from geneSymbol) uc332xmo.1 uc332xmo.1 
ENSMUST00000272111.1 ENSMUSG00000125754 ENSMUST00000272111.1 ENSMUSG00000125754 (from geneSymbol) uc332xmq.1 uc332xmq.1 
ENSMUST00000272113.1 ENSMUSG00000125755 ENSMUST00000272113.1 ENSMUSG00000125755 (from geneSymbol) uc332xms.1 uc332xms.1 
ENSMUST00000272120.1 ENSMUSG00000125756 ENSMUST00000272120.1 ENSMUSG00000125756 (from geneSymbol) uc332xmz.1 uc332xmz.1 
ENSMUST00000272121.1 1700058P15Rik ENSMUST00000272121.1 1700058P15Rik (from geneSymbol) AK006836 uc332xna.1 uc332xna.1 
ENSMUST00000272127.1 ENSMUSG00000125757 ENSMUST00000272127.1 ENSMUSG00000125757 (from geneSymbol) uc332xnf.1 uc332xnf.1 
ENSMUST00000272133.1 ENSMUSG00000125758 ENSMUST00000272133.1 ENSMUSG00000125758 (from geneSymbol) uc332xnl.1 uc332xnl.1 
ENSMUST00000272140.1 ENSMUSG00000125759 ENSMUST00000272140.1 ENSMUSG00000125759 (from geneSymbol) uc332xns.1 uc332xns.1 
ENSMUST00000272141.1 ENSMUSG00000125760 ENSMUST00000272141.1 ENSMUSG00000125760 (from geneSymbol) uc332xnt.1 uc332xnt.1 
ENSMUST00000272143.1 ENSMUSG00000125761 ENSMUST00000272143.1 ENSMUSG00000125761 (from geneSymbol) uc332xnv.1 uc332xnv.1 
ENSMUST00000272144.1 ENSMUSG00000125762 ENSMUST00000272144.1 ENSMUSG00000125762 (from geneSymbol) uc332xnw.1 uc332xnw.1 
ENSMUST00000272146.1 ENSMUSG00000125763 ENSMUST00000272146.1 ENSMUSG00000125763 (from geneSymbol) uc332xny.1 uc332xny.1 
ENSMUST00000272147.1 ENSMUSG00000125764 ENSMUST00000272147.1 ENSMUSG00000125764 (from geneSymbol) uc332xnz.1 uc332xnz.1 
ENSMUST00000272148.1 Gm35588 ENSMUST00000272148.1 Gm35588 (from geneSymbol) uc332xoa.1 uc332xoa.1 
ENSMUST00000272150.1 Gm16168 ENSMUST00000272150.1 Gm16168 (from geneSymbol) uc332xoc.1 uc332xoc.1 
ENSMUST00000272151.1 ENSMUSG00000125765 ENSMUST00000272151.1 ENSMUSG00000125765 (from geneSymbol) uc332xod.1 uc332xod.1 
ENSMUST00000272165.1 ENSMUSG00000125766 ENSMUST00000272165.1 ENSMUSG00000125766 (from geneSymbol) uc332xor.1 uc332xor.1 
ENSMUST00000272166.1 ENSMUSG00000125767 ENSMUST00000272166.1 ENSMUSG00000125767 (from geneSymbol) uc332xos.1 uc332xos.1 
ENSMUST00000272167.1 ENSMUSG00000125768 ENSMUST00000272167.1 ENSMUSG00000125768 (from geneSymbol) uc332xot.1 uc332xot.1 
ENSMUST00000272169.1 ENSMUSG00000125769 ENSMUST00000272169.1 ENSMUSG00000125769 (from geneSymbol) uc332xov.1 uc332xov.1 
ENSMUST00000272170.1 ENSMUSG00000125770 ENSMUST00000272170.1 ENSMUSG00000125770 (from geneSymbol) uc332xow.1 uc332xow.1 
ENSMUST00000272171.1 ENSMUSG00000125771 ENSMUST00000272171.1 ENSMUSG00000125771 (from geneSymbol) uc332xox.1 uc332xox.1 
ENSMUST00000272173.1 ENSMUSG00000125772 ENSMUST00000272173.1 ENSMUSG00000125772 (from geneSymbol) uc332xoz.1 uc332xoz.1 
ENSMUST00000272178.1 ENSMUSG00000125773 ENSMUST00000272178.1 ENSMUSG00000125773 (from geneSymbol) uc332xpe.1 uc332xpe.1 
ENSMUST00000272185.1 ENSMUSG00000125774 ENSMUST00000272185.1 ENSMUSG00000125774 (from geneSymbol) uc332xpl.1 uc332xpl.1 
ENSMUST00000272188.1 ENSMUSG00000125776 ENSMUST00000272188.1 ENSMUSG00000125776 (from geneSymbol) uc332xpn.1 uc332xpn.1 
ENSMUST00000272189.1 ENSMUSG00000125777 ENSMUST00000272189.1 ENSMUSG00000125777 (from geneSymbol) uc332xpo.1 uc332xpo.1 
ENSMUST00000272190.1 ENSMUSG00000125778 ENSMUST00000272190.1 ENSMUSG00000125778 (from geneSymbol) uc332xpp.1 uc332xpp.1 
ENSMUST00000272191.1 ENSMUSG00000125779 ENSMUST00000272191.1 ENSMUSG00000125779 (from geneSymbol) uc332xpq.1 uc332xpq.1 
ENSMUST00000272192.1 ENSMUSG00000125780 ENSMUST00000272192.1 ENSMUSG00000125780 (from geneSymbol) uc332xpr.1 uc332xpr.1 
ENSMUST00000272193.1 ENSMUSG00000125781 ENSMUST00000272193.1 ENSMUSG00000125781 (from geneSymbol) uc332xps.1 uc332xps.1 
ENSMUST00000272195.1 ENSMUSG00000125782 ENSMUST00000272195.1 ENSMUSG00000125782 (from geneSymbol) uc332xpu.1 uc332xpu.1 
ENSMUST00000272198.1 ENSMUSG00000125783 ENSMUST00000272198.1 ENSMUSG00000125783 (from geneSymbol) uc332xpx.1 uc332xpx.1 
ENSMUST00000272207.1 ENSMUSG00000125784 ENSMUST00000272207.1 ENSMUSG00000125784 (from geneSymbol) uc332xqg.1 uc332xqg.1 
ENSMUST00000272208.1 ENSMUSG00000125785 ENSMUST00000272208.1 ENSMUSG00000125785 (from geneSymbol) uc332xqh.1 uc332xqh.1 
ENSMUST00000272210.1 Gm33847 ENSMUST00000272210.1 Gm33847 (from geneSymbol) AK016172 uc332xqi.1 uc332xqi.1 
ENSMUST00000272226.1 ENSMUSG00000125788 ENSMUST00000272226.1 ENSMUSG00000125788 (from geneSymbol) uc332xqx.1 uc332xqx.1 
ENSMUST00000272227.1 ENSMUSG00000125789 ENSMUST00000272227.1 ENSMUSG00000125789 (from geneSymbol) uc332xqy.1 uc332xqy.1 
ENSMUST00000272229.1 ENSMUSG00000125790 ENSMUST00000272229.1 ENSMUSG00000125790 (from geneSymbol) uc332xra.1 uc332xra.1 
ENSMUST00000272238.1 Gm30564 ENSMUST00000272238.1 Gm30564 (from geneSymbol) AK079047 uc332xrj.1 uc332xrj.1 
ENSMUST00000272241.1 ENSMUSG00000125791 ENSMUST00000272241.1 ENSMUSG00000125791 (from geneSymbol) uc332xrm.1 uc332xrm.1 
ENSMUST00000272246.1 Gm5524 ENSMUST00000272246.1 Gm5524 (from geneSymbol) AK050085 uc332xrr.1 uc332xrr.1 
ENSMUST00000272247.1 ENSMUSG00000125792 ENSMUST00000272247.1 ENSMUSG00000125792 (from geneSymbol) uc332xrs.1 uc332xrs.1 
ENSMUST00000272248.1 ENSMUSG00000125793 ENSMUST00000272248.1 ENSMUSG00000125793 (from geneSymbol) uc332xrt.1 uc332xrt.1 
ENSMUST00000272249.1 Gm20515 ENSMUST00000272249.1 Gm20515 (from geneSymbol) AK034351 uc332xru.1 uc332xru.1 
ENSMUST00000272286.1 ENSMUSG00000125794 ENSMUST00000272286.1 ENSMUSG00000125794 (from geneSymbol) uc332xtf.1 uc332xtf.1 
ENSMUST00000272292.1 ENSMUSG00000125795 ENSMUST00000272292.1 ENSMUSG00000125795 (from geneSymbol) uc332xtl.1 uc332xtl.1 
ENSMUST00000272294.1 ENSMUSG00000125796 ENSMUST00000272294.1 ENSMUSG00000125796 (from geneSymbol) uc332xtn.1 uc332xtn.1 
ENSMUST00000272308.1 Gm47902 ENSMUST00000272308.1 Gm47902 (from geneSymbol) uc332xub.1 uc332xub.1 
ENSMUST00000272310.1 Gm4221 ENSMUST00000272310.1 Gm4221 (from geneSymbol) AK163160 uc332xud.1 uc332xud.1 
ENSMUST00000272352.1 ENSMUSG00000125797 ENSMUST00000272352.1 ENSMUSG00000125797 (from geneSymbol) uc332xvt.1 uc332xvt.1 
ENSMUST00000272355.1 ENSMUSG00000125798 ENSMUST00000272355.1 ENSMUSG00000125798 (from geneSymbol) uc332xvw.1 uc332xvw.1 
ENSMUST00000272356.1 ENSMUSG00000125799 ENSMUST00000272356.1 ENSMUSG00000125799 (from geneSymbol) uc332xvx.1 uc332xvx.1 
ENSMUST00000272361.1 ENSMUSG00000125801 ENSMUST00000272361.1 ENSMUSG00000125801 (from geneSymbol) uc332xwb.1 uc332xwb.1 
ENSMUST00000272364.1 ENSMUSG00000125802 ENSMUST00000272364.1 ENSMUSG00000125802 (from geneSymbol) uc332xwe.1 uc332xwe.1 
ENSMUST00000272365.1 ENSMUSG00000125803 ENSMUST00000272365.1 ENSMUSG00000125803 (from geneSymbol) uc332xwf.1 uc332xwf.1 
ENSMUST00000272368.1 ENSMUSG00000125804 ENSMUST00000272368.1 ENSMUSG00000125804 (from geneSymbol) uc332xwi.1 uc332xwi.1 
ENSMUST00000272369.1 ENSMUSG00000125805 ENSMUST00000272369.1 ENSMUSG00000125805 (from geneSymbol) uc332xwj.1 uc332xwj.1 
ENSMUST00000272370.1 ENSMUSG00000125806 ENSMUST00000272370.1 ENSMUSG00000125806 (from geneSymbol) EF591879 uc332xwk.1 uc332xwk.1 
ENSMUST00000272371.1 ENSMUSG00000125807 ENSMUST00000272371.1 ENSMUSG00000125807 (from geneSymbol) uc332xwl.1 uc332xwl.1 
ENSMUST00000272372.1 ENSMUSG00000125808 ENSMUST00000272372.1 ENSMUSG00000125808 (from geneSymbol) uc332xwm.1 uc332xwm.1 
ENSMUST00000272373.1 ENSMUSG00000125809 ENSMUST00000272373.1 ENSMUSG00000125809 (from geneSymbol) uc332xwn.1 uc332xwn.1 
ENSMUST00000272374.1 Gm18800 ENSMUST00000272374.1 Gm18800 (from geneSymbol) AK034746 uc332xwo.1 uc332xwo.1 
ENSMUST00000272376.1 ENSMUSG00000125810 ENSMUST00000272376.1 ENSMUSG00000125810 (from geneSymbol) uc332xwq.1 uc332xwq.1 
ENSMUST00000272377.1 Gm21691 ENSMUST00000272377.1 Gm21691 (from geneSymbol) uc332xwr.1 uc332xwr.1 
ENSMUST00000272393.1 ENSMUSG00000125811 ENSMUST00000272393.1 ENSMUSG00000125811 (from geneSymbol) uc332xxh.1 uc332xxh.1 
ENSMUST00000272401.1 ENSMUSG00000125812 ENSMUST00000272401.1 ENSMUSG00000125812 (from geneSymbol) uc332xxp.1 uc332xxp.1 
ENSMUST00000272404.1 ENSMUSG00000125813 ENSMUST00000272404.1 ENSMUSG00000125813 (from geneSymbol) uc332xxs.1 uc332xxs.1 
ENSMUST00000272407.1 ENSMUSG00000125814 ENSMUST00000272407.1 ENSMUSG00000125814 (from geneSymbol) uc332xxv.1 uc332xxv.1 
ENSMUST00000272411.1 ENSMUSG00000125815 ENSMUST00000272411.1 ENSMUSG00000125815 (from geneSymbol) uc332xxy.1 uc332xxy.1 
ENSMUST00000272435.1 ENSMUSG00000125816 ENSMUST00000272435.1 ENSMUSG00000125816 (from geneSymbol) uc332xyw.1 uc332xyw.1 
ENSMUST00000272440.1 Gm15934 ENSMUST00000272440.1 Gm15934 (from geneSymbol) uc332xzb.1 uc332xzb.1 
ENSMUST00000272444.1 ENSMUSG00000125817 ENSMUST00000272444.1 ENSMUSG00000125817 (from geneSymbol) uc332xzf.1 uc332xzf.1 
ENSMUST00000272445.1 ENSMUSG00000125818 ENSMUST00000272445.1 ENSMUSG00000125818 (from geneSymbol) uc332xzg.1 uc332xzg.1 
ENSMUST00000272446.1 ENSMUSG00000125819 ENSMUST00000272446.1 ENSMUSG00000125819 (from geneSymbol) uc332xzh.1 uc332xzh.1 
ENSMUST00000272449.1 ENSMUSG00000125820 ENSMUST00000272449.1 ENSMUSG00000125820 (from geneSymbol) uc332xzk.1 uc332xzk.1 
ENSMUST00000272461.1 ENSMUSG00000125821 ENSMUST00000272461.1 ENSMUSG00000125821 (from geneSymbol) uc332xzw.1 uc332xzw.1 
ENSMUST00000272462.1 ENSMUSG00000125822 ENSMUST00000272462.1 ENSMUSG00000125822 (from geneSymbol) uc332xzx.1 uc332xzx.1 
ENSMUST00000272464.1 Zfp652os ENSMUST00000272464.1 Zfp652os (from geneSymbol) AK027957 uc332xzz.1 uc332xzz.1 
ENSMUST00000272484.1 ENSMUSG00000125823 ENSMUST00000272484.1 ENSMUSG00000125823 (from geneSymbol) uc332yat.1 uc332yat.1 
ENSMUST00000272487.1 ENSMUSG00000125824 ENSMUST00000272487.1 ENSMUSG00000125824 (from geneSymbol) uc332yaw.1 uc332yaw.1 
ENSMUST00000272492.1 ENSMUSG00000125825 ENSMUST00000272492.1 ENSMUSG00000125825 (from geneSymbol) uc332ybb.1 uc332ybb.1 
ENSMUST00000272494.1 ENSMUSG00000125826 ENSMUST00000272494.1 ENSMUSG00000125826 (from geneSymbol) uc332ybd.1 uc332ybd.1 
ENSMUST00000272495.1 ENSMUSG00000125827 ENSMUST00000272495.1 ENSMUSG00000125827 (from geneSymbol) uc332ybe.1 uc332ybe.1 
ENSMUST00000272497.1 4930422I22Rik ENSMUST00000272497.1 4930422I22Rik (from geneSymbol) AK015180 uc332ybg.1 uc332ybg.1 
ENSMUST00000272505.1 ENSMUSG00000125828 ENSMUST00000272505.1 ENSMUSG00000125828 (from geneSymbol) uc332ybo.1 uc332ybo.1 
ENSMUST00000272506.1 ENSMUSG00000125829 ENSMUST00000272506.1 ENSMUSG00000125829 (from geneSymbol) uc332ybp.1 uc332ybp.1 
ENSMUST00000272507.1 ENSMUSG00000125830 ENSMUST00000272507.1 RIKEN cDNA 6330525I24 gene, transcript variant 3 (from RefSeq NR_165797.1) NR_165797 uc332ybq.1 uc332ybq.1 
ENSMUST00000272514.1 ENSMUSG00000125831 ENSMUST00000272514.1 ENSMUSG00000125831 (from geneSymbol) uc332ybx.1 uc332ybx.1 
ENSMUST00000272515.1 ENSMUSG00000125832 ENSMUST00000272515.1 ENSMUSG00000125832 (from geneSymbol) uc332yby.1 uc332yby.1 
ENSMUST00000272519.1 ENSMUSG00000125833 ENSMUST00000272519.1 ENSMUSG00000125833 (from geneSymbol) uc332ycc.1 uc332ycc.1 
ENSMUST00000272520.1 ENSMUSG00000125834 ENSMUST00000272520.1 ENSMUSG00000125834 (from geneSymbol) uc332ycd.1 uc332ycd.1 
ENSMUST00000272523.1 Gm17202 ENSMUST00000272523.1 Gm17202 (from geneSymbol) AK043597 uc332ycg.1 uc332ycg.1 
ENSMUST00000272529.1 ENSMUSG00000125835 ENSMUST00000272529.1 ENSMUSG00000125835 (from geneSymbol) uc332ycm.1 uc332ycm.1 
ENSMUST00000272532.1 D730050B12Rik ENSMUST00000272532.1 D730050B12Rik (from geneSymbol) uc332ycp.1 uc332ycp.1 
ENSMUST00000272549.1 ENSMUSG00000125836 ENSMUST00000272549.1 ENSMUSG00000125836 (from geneSymbol) uc332ydg.1 uc332ydg.1 
ENSMUST00000272551.1 2210414B05Rik ENSMUST00000272551.1 RIKEN cDNA 2210414B05 gene (from RefSeq NR_040643.1) NR_040643 uc332ydi.1 uc332ydi.1 
ENSMUST00000272552.1 ENSMUSG00000125837 ENSMUST00000272552.1 ENSMUSG00000125837 (from geneSymbol) uc332ydj.1 uc332ydj.1 
ENSMUST00000272555.1 ENSMUSG00000125838 ENSMUST00000272555.1 ENSMUSG00000125838 (from geneSymbol) uc332ydm.1 uc332ydm.1 
ENSMUST00000272566.1 ENSMUSG00000125839 ENSMUST00000272566.1 ENSMUSG00000125839 (from geneSymbol) uc332ydx.1 uc332ydx.1 
ENSMUST00000272568.1 ENSMUSG00000125840 ENSMUST00000272568.1 ENSMUSG00000125840 (from geneSymbol) uc332ydz.1 uc332ydz.1 
ENSMUST00000272572.1 ENSMUSG00000125841 ENSMUST00000272572.1 ENSMUSG00000125841 (from geneSymbol) uc332yed.1 uc332yed.1 
ENSMUST00000272579.1 Gm20619 ENSMUST00000272579.1 Gm20619 (from geneSymbol) AK015284 uc332yek.1 uc332yek.1 
ENSMUST00000272782.1 ENSMUSG00000125842 ENSMUST00000272782.1 ENSMUSG00000125842 (from geneSymbol) uc332ymf.1 uc332ymf.1 
ENSMUST00000272785.1 ENSMUSG00000125843 ENSMUST00000272785.1 ENSMUSG00000125843 (from geneSymbol) uc332ymi.1 uc332ymi.1 
ENSMUST00000272796.1 Gm28777 ENSMUST00000272796.1 Gm28777 (from geneSymbol) AK052226 uc332ymt.1 uc332ymt.1 
ENSMUST00000272809.1 4933406K04Rik ENSMUST00000272809.1 4933406K04Rik (from geneSymbol) AK016950 uc332yng.1 uc332yng.1 
ENSMUST00000272837.1 ENSMUSG00000125844 ENSMUST00000272837.1 ENSMUSG00000125844 (from geneSymbol) uc332yoi.1 uc332yoi.1 
ENSMUST00000272838.1 ENSMUSG00000125845 ENSMUST00000272838.1 ENSMUSG00000125845 (from geneSymbol) uc332yoj.1 uc332yoj.1 
ENSMUST00000272839.1 1700119H24Rik ENSMUST00000272839.1 1700119H24Rik (from geneSymbol) AK007207 uc332yok.1 uc332yok.1 
ENSMUST00000272844.1 ENSMUSG00000125846 ENSMUST00000272844.1 ENSMUSG00000125846 (from geneSymbol) uc332yop.1 uc332yop.1 
ENSMUST00000272845.1 ENSMUSG00000125847 ENSMUST00000272845.1 ENSMUSG00000125847 (from geneSymbol) uc332yoq.1 uc332yoq.1 
ENSMUST00000272846.1 ENSMUSG00000125848 ENSMUST00000272846.1 ENSMUSG00000125848 (from geneSymbol) uc332yor.1 uc332yor.1 
ENSMUST00000272848.1 ENSMUSG00000125849 ENSMUST00000272848.1 ENSMUSG00000125849 (from geneSymbol) uc332yot.1 uc332yot.1 
ENSMUST00000272851.1 ENSMUSG00000125850 ENSMUST00000272851.1 ENSMUSG00000125850 (from geneSymbol) uc332yow.1 uc332yow.1 
ENSMUST00000272853.1 ENSMUSG00000125851 ENSMUST00000272853.1 ENSMUSG00000125851 (from geneSymbol) uc332yoy.1 uc332yoy.1 
ENSMUST00000272866.1 ENSMUSG00000125852 ENSMUST00000272866.1 ENSMUSG00000125852 (from geneSymbol) uc332ypl.1 uc332ypl.1 
ENSMUST00000272870.1 ENSMUSG00000125853 ENSMUST00000272870.1 ENSMUSG00000125853 (from geneSymbol) uc332ypp.1 uc332ypp.1 
ENSMUST00000272871.1 ENSMUSG00000125854 ENSMUST00000272871.1 ENSMUSG00000125854 (from geneSymbol) uc332ypq.1 uc332ypq.1 
ENSMUST00000272872.1 ENSMUSG00000125855 ENSMUST00000272872.1 ENSMUSG00000125855 (from geneSymbol) uc332ypr.1 uc332ypr.1 
ENSMUST00000272873.1 ENSMUSG00000125856 ENSMUST00000272873.1 ENSMUSG00000125856 (from geneSymbol) uc332yps.1 uc332yps.1 
ENSMUST00000272875.1 ENSMUSG00000125857 ENSMUST00000272875.1 ENSMUSG00000125857 (from geneSymbol) uc332ypu.1 uc332ypu.1 
ENSMUST00000272879.1 Gm29128 ENSMUST00000272879.1 Gm29128 (from geneSymbol) AK139037 uc332ypy.1 uc332ypy.1 
ENSMUST00000272892.1 ENSMUSG00000125858 ENSMUST00000272892.1 ENSMUSG00000125858 (from geneSymbol) uc332yql.1 uc332yql.1 
ENSMUST00000272913.1 ENSMUSG00000125859 ENSMUST00000272913.1 ENSMUSG00000125859 (from geneSymbol) uc332yrg.1 uc332yrg.1 
ENSMUST00000272914.1 ENSMUSG00000125860 ENSMUST00000272914.1 ENSMUSG00000125860 (from geneSymbol) uc332yrh.1 uc332yrh.1 
ENSMUST00000272917.1 ENSMUSG00000125861 ENSMUST00000272917.1 ENSMUSG00000125861 (from geneSymbol) uc332yrk.1 uc332yrk.1 
ENSMUST00000272918.1 ENSMUSG00000125862 ENSMUST00000272918.1 ENSMUSG00000125862 (from geneSymbol) uc332yrl.1 uc332yrl.1 
ENSMUST00000272919.1 ENSMUSG00000125863 ENSMUST00000272919.1 ENSMUSG00000125863 (from geneSymbol) uc332yrm.1 uc332yrm.1 
ENSMUST00000272921.1 ENSMUSG00000125864 ENSMUST00000272921.1 ENSMUSG00000125864 (from geneSymbol) uc332yro.1 uc332yro.1 
ENSMUST00000272922.1 ENSMUSG00000125865 ENSMUST00000272922.1 ENSMUSG00000125865 (from geneSymbol) uc332yrp.1 uc332yrp.1 
ENSMUST00000272924.1 ENSMUSG00000125866 ENSMUST00000272924.1 ENSMUSG00000125866 (from geneSymbol) uc332yrr.1 uc332yrr.1 
ENSMUST00000272930.1 ENSMUSG00000125867 ENSMUST00000272930.1 ENSMUSG00000125867 (from geneSymbol) uc332yrx.1 uc332yrx.1 
ENSMUST00000272933.1 Gm42891 ENSMUST00000272933.1 Gm42891 (from geneSymbol) uc332ysa.1 uc332ysa.1 
ENSMUST00000272942.1 ENSMUSG00000125868 ENSMUST00000272942.1 ENSMUSG00000125868 (from geneSymbol) uc332ysj.1 uc332ysj.1 
ENSMUST00000272944.1 ENSMUSG00000125869 ENSMUST00000272944.1 ENSMUSG00000125869 (from geneSymbol) uc332ysl.1 uc332ysl.1 
ENSMUST00000272945.1 ENSMUSG00000125870 ENSMUST00000272945.1 ENSMUSG00000125870 (from geneSymbol) uc332ysm.1 uc332ysm.1 
ENSMUST00000272947.1 ENSMUSG00000125871 ENSMUST00000272947.1 ENSMUSG00000125871 (from geneSymbol) uc332yso.1 uc332yso.1 
ENSMUST00000272953.1 ENSMUSG00000125872 ENSMUST00000272953.1 ENSMUSG00000125872 (from geneSymbol) uc332ysu.1 uc332ysu.1 
ENSMUST00000272956.1 ENSMUSG00000125873 ENSMUST00000272956.1 ENSMUSG00000125873 (from geneSymbol) uc332ysx.1 uc332ysx.1 
ENSMUST00000272962.1 ENSMUSG00000125874 ENSMUST00000272962.1 ENSMUSG00000125874 (from geneSymbol) uc332ytd.1 uc332ytd.1 
ENSMUST00000272964.1 ENSMUSG00000125875 ENSMUST00000272964.1 ENSMUSG00000125875 (from geneSymbol) uc332ytf.1 uc332ytf.1 
ENSMUST00000272965.1 ENSMUSG00000125876 ENSMUST00000272965.1 ENSMUSG00000125876 (from geneSymbol) uc332ytg.1 uc332ytg.1 
ENSMUST00000272966.1 ENSMUSG00000125877 ENSMUST00000272966.1 ENSMUSG00000125877 (from geneSymbol) uc332yth.1 uc332yth.1 
ENSMUST00000272968.1 ENSMUSG00000125878 ENSMUST00000272968.1 ENSMUSG00000125878 (from geneSymbol) uc332ytj.1 uc332ytj.1 
ENSMUST00000272969.1 ENSMUSG00000125879 ENSMUST00000272969.1 ENSMUSG00000125879 (from geneSymbol) uc332ytk.1 uc332ytk.1 
ENSMUST00000272971.1 ENSMUSG00000125880 ENSMUST00000272971.1 ENSMUSG00000125880 (from geneSymbol) uc332ytm.1 uc332ytm.1 
ENSMUST00000272980.1 ENSMUSG00000125881 ENSMUST00000272980.1 ENSMUSG00000125881 (from geneSymbol) uc332ytv.1 uc332ytv.1 
ENSMUST00000272985.1 ENSMUSG00000125882 ENSMUST00000272985.1 ENSMUSG00000125882 (from geneSymbol) uc332yua.1 uc332yua.1 
ENSMUST00000272987.1 ENSMUSG00000125884 ENSMUST00000272987.1 ENSMUSG00000125884 (from geneSymbol) uc332yub.1 uc332yub.1 
ENSMUST00000272988.1 ENSMUSG00000125885 ENSMUST00000272988.1 ENSMUSG00000125885 (from geneSymbol) uc332yuc.1 uc332yuc.1 
ENSMUST00000272989.1 ENSMUSG00000125886 ENSMUST00000272989.1 ENSMUSG00000125886 (from geneSymbol) uc332yud.1 uc332yud.1 
ENSMUST00000272992.1 ENSMUSG00000125887 ENSMUST00000272992.1 ENSMUSG00000125887 (from geneSymbol) uc332yug.1 uc332yug.1 
ENSMUST00000272993.1 ENSMUSG00000125888 ENSMUST00000272993.1 ENSMUSG00000125888 (from geneSymbol) uc332yuh.1 uc332yuh.1 
ENSMUST00000272998.1 ENSMUSG00000125889 ENSMUST00000272998.1 ENSMUSG00000125889 (from geneSymbol) uc332yum.1 uc332yum.1 
ENSMUST00000273005.1 ENSMUSG00000125890 ENSMUST00000273005.1 ENSMUSG00000125890 (from geneSymbol) uc332yut.1 uc332yut.1 
ENSMUST00000273007.1 ENSMUSG00000125891 ENSMUST00000273007.1 ENSMUSG00000125891 (from geneSymbol) uc332yuv.1 uc332yuv.1 
ENSMUST00000273009.1 ENSMUSG00000125892 ENSMUST00000273009.1 ENSMUSG00000125892 (from geneSymbol) uc332yux.1 uc332yux.1 
ENSMUST00000273010.1 ENSMUSG00000125893 ENSMUST00000273010.1 ENSMUSG00000125893 (from geneSymbol) uc332yuy.1 uc332yuy.1 
ENSMUST00000273011.1 Gm20618 ENSMUST00000273011.1 Gm20618 (from geneSymbol) uc332yuz.1 uc332yuz.1 
ENSMUST00000273022.1 ENSMUSG00000125894 ENSMUST00000273022.1 ENSMUSG00000125894 (from geneSymbol) AK043290 uc332yvk.1 uc332yvk.1 
ENSMUST00000273029.1 ENSMUSG00000125895 ENSMUST00000273029.1 ENSMUSG00000125895 (from geneSymbol) uc332yvr.1 uc332yvr.1 
ENSMUST00000273030.1 ENSMUSG00000125896 ENSMUST00000273030.1 ENSMUSG00000125896 (from geneSymbol) uc332yvs.1 uc332yvs.1 
ENSMUST00000273046.1 ENSMUSG00000125897 ENSMUST00000273046.1 ENSMUSG00000125897 (from geneSymbol) uc332ywi.1 uc332ywi.1 
ENSMUST00000273049.1 ENSMUSG00000125898 ENSMUST00000273049.1 ENSMUSG00000125898 (from geneSymbol) uc332ywl.1 uc332ywl.1 
ENSMUST00000273050.1 2810414N06Rik ENSMUST00000273050.1 2810414N06Rik (from geneSymbol) KY467515 uc332ywm.1 uc332ywm.1 
ENSMUST00000273056.1 ENSMUSG00000125899 ENSMUST00000273056.1 ENSMUSG00000125899 (from geneSymbol) uc332yws.1 uc332yws.1 
ENSMUST00000273057.1 ENSMUSG00000125900 ENSMUST00000273057.1 ENSMUSG00000125900 (from geneSymbol) uc332ywt.1 uc332ywt.1 
ENSMUST00000273072.1 ENSMUSG00000125902 ENSMUST00000273072.1 ENSMUSG00000125902 (from geneSymbol) uc332ywu.1 uc332ywu.1 
ENSMUST00000273074.1 ENSMUSG00000125903 ENSMUST00000273074.1 ENSMUSG00000125903 (from geneSymbol) uc332yww.1 uc332yww.1 
ENSMUST00000273077.1 ENSMUSG00000125904 ENSMUST00000273077.1 ENSMUSG00000125904 (from geneSymbol) uc332ywz.1 uc332ywz.1 
ENSMUST00000273087.1 Gm16998 ENSMUST00000273087.1 Gm16998 (from geneSymbol) AK138755 uc332yxj.1 uc332yxj.1 
ENSMUST00000273090.1 ENSMUSG00000125905 ENSMUST00000273090.1 ENSMUSG00000125905 (from geneSymbol) uc332yxm.1 uc332yxm.1 
ENSMUST00000273092.1 4930555F03Rik ENSMUST00000273092.1 4930555F03Rik (from geneSymbol) AK016128 uc332yxo.1 uc332yxo.1 
ENSMUST00000273203.1 ENSMUSG00000125906 ENSMUST00000273203.1 ENSMUSG00000125906 (from geneSymbol) uc332zbv.1 uc332zbv.1 
ENSMUST00000273237.1 ENSMUSG00000125907 ENSMUST00000273237.1 ENSMUSG00000125907 (from geneSymbol) uc332zdd.1 uc332zdd.1 
ENSMUST00000273239.1 ENSMUSG00000125908 ENSMUST00000273239.1 ENSMUSG00000125908 (from geneSymbol) uc332zdf.1 uc332zdf.1 
ENSMUST00000273246.1 ENSMUSG00000125909 ENSMUST00000273246.1 ENSMUSG00000125909 (from geneSymbol) uc332zdm.1 uc332zdm.1 
ENSMUST00000273248.1 ENSMUSG00000125910 ENSMUST00000273248.1 ENSMUSG00000125910 (from geneSymbol) uc332zdo.1 uc332zdo.1 
ENSMUST00000273249.1 ENSMUSG00000125911 ENSMUST00000273249.1 ENSMUSG00000125911 (from geneSymbol) uc332zdp.1 uc332zdp.1 
ENSMUST00000273250.1 ENSMUSG00000125912 ENSMUST00000273250.1 ENSMUSG00000125912 (from geneSymbol) uc332zdq.1 uc332zdq.1 
ENSMUST00000273251.1 ENSMUSG00000125913 ENSMUST00000273251.1 ENSMUSG00000125913 (from geneSymbol) uc332zdr.1 uc332zdr.1 
ENSMUST00000273252.1 ENSMUSG00000125914 ENSMUST00000273252.1 ENSMUSG00000125914 (from geneSymbol) uc332zds.1 uc332zds.1 
ENSMUST00000273253.1 ENSMUSG00000125915 ENSMUST00000273253.1 ENSMUSG00000125915 (from geneSymbol) uc332zdt.1 uc332zdt.1 
ENSMUST00000273254.1 ENSMUSG00000125916 ENSMUST00000273254.1 ENSMUSG00000125916 (from geneSymbol) uc332zdu.1 uc332zdu.1 
ENSMUST00000273255.1 ENSMUSG00000125917 ENSMUST00000273255.1 ENSMUSG00000125917 (from geneSymbol) uc332zdv.1 uc332zdv.1 
ENSMUST00000273256.1 ENSMUSG00000125918 ENSMUST00000273256.1 ENSMUSG00000125918 (from geneSymbol) uc332zdw.1 uc332zdw.1 
ENSMUST00000273257.1 ENSMUSG00000125919 ENSMUST00000273257.1 ENSMUSG00000125919 (from geneSymbol) uc332zdx.1 uc332zdx.1 
ENSMUST00000273258.1 ENSMUSG00000125920 ENSMUST00000273258.1 ENSMUSG00000125920 (from geneSymbol) uc332zdy.1 uc332zdy.1 
ENSMUST00000273259.1 ENSMUSG00000125921 ENSMUST00000273259.1 ENSMUSG00000125921 (from geneSymbol) uc332zdz.1 uc332zdz.1 
ENSMUST00000273260.1 ENSMUSG00000125922 ENSMUST00000273260.1 ENSMUSG00000125922 (from geneSymbol) uc332zea.1 uc332zea.1 
ENSMUST00000273267.1 1700072B07Rik ENSMUST00000273267.1 1700072B07Rik (from geneSymbol) AK006934 uc332zeh.1 uc332zeh.1 
ENSMUST00000273298.1 ENSMUSG00000125923 ENSMUST00000273298.1 ENSMUSG00000125923 (from geneSymbol) uc332zfm.1 uc332zfm.1 
ENSMUST00000273305.1 ENSMUSG00000125925 ENSMUST00000273305.1 ENSMUSG00000125925 (from geneSymbol) uc332zfr.1 uc332zfr.1 
ENSMUST00000273308.1 Gm20560 ENSMUST00000273308.1 Gm20560 (from geneSymbol) AK084852 uc332zfu.1 uc332zfu.1 
ENSMUST00000273314.1 ENSMUSG00000125926 ENSMUST00000273314.1 ENSMUSG00000125926 (from geneSymbol) uc332zga.1 uc332zga.1 
ENSMUST00000273315.1 Gm57281 ENSMUST00000273315.1 Gm57281 (from geneSymbol) uc332zgb.1 uc332zgb.1 
ENSMUST00000273322.1 ENSMUSG00000125928 ENSMUST00000273322.1 ENSMUSG00000125928 (from geneSymbol) uc332zgh.1 uc332zgh.1 
ENSMUST00000273328.1 ENSMUSG00000125930 ENSMUST00000273328.1 ENSMUSG00000125930 (from geneSymbol) uc332zgl.1 uc332zgl.1 
ENSMUST00000273332.1 ENSMUSG00000125931 ENSMUST00000273332.1 ENSMUSG00000125931 (from geneSymbol) uc332zgp.1 uc332zgp.1 
ENSMUST00000273336.1 ENSMUSG00000125932 ENSMUST00000273336.1 ENSMUSG00000125932 (from geneSymbol) uc332zgt.1 uc332zgt.1 
ENSMUST00000273338.1 ENSMUSG00000125933 ENSMUST00000273338.1 ENSMUSG00000125933 (from geneSymbol) uc332zgv.1 uc332zgv.1 
ENSMUST00000273339.1 ENSMUSG00000125934 ENSMUST00000273339.1 ENSMUSG00000125934 (from geneSymbol) uc332zgw.1 uc332zgw.1 
ENSMUST00000273340.1 ENSMUSG00000125935 ENSMUST00000273340.1 ENSMUSG00000125935 (from geneSymbol) uc332zgx.1 uc332zgx.1 
ENSMUST00000273343.1 ENSMUSG00000125936 ENSMUST00000273343.1 ENSMUSG00000125936 (from geneSymbol) uc332zha.1 uc332zha.1 
ENSMUST00000273357.1 ENSMUSG00000125937 ENSMUST00000273357.1 ENSMUSG00000125937 (from geneSymbol) uc332zho.1 uc332zho.1 
ENSMUST00000273358.1 ENSMUSG00000125938 ENSMUST00000273358.1 ENSMUSG00000125938 (from geneSymbol) uc332zhp.1 uc332zhp.1 
ENSMUST00000273359.1 ENSMUSG00000125939 ENSMUST00000273359.1 ENSMUSG00000125939 (from geneSymbol) uc332zhq.1 uc332zhq.1 
ENSMUST00000273360.1 ENSMUSG00000125940 ENSMUST00000273360.1 ENSMUSG00000125940 (from geneSymbol) uc332zhr.1 uc332zhr.1 
ENSMUST00000273363.1 ENSMUSG00000125941 ENSMUST00000273363.1 ENSMUSG00000125941 (from geneSymbol) uc332zhu.1 uc332zhu.1 
ENSMUST00000273364.1 ENSMUSG00000125942 ENSMUST00000273364.1 ENSMUSG00000125942 (from geneSymbol) uc332zhv.1 uc332zhv.1 
ENSMUST00000273368.1 Gm15222 ENSMUST00000273368.1 Gm15222 (from geneSymbol) uc332zhz.1 uc332zhz.1 
ENSMUST00000273371.1 ENSMUSG00000125943 ENSMUST00000273371.1 ENSMUSG00000125943 (from geneSymbol) uc332zic.1 uc332zic.1 
ENSMUST00000273373.1 ENSMUSG00000125944 ENSMUST00000273373.1 ENSMUSG00000125944 (from geneSymbol) uc332zie.1 uc332zie.1 
ENSMUST00000273488.1 Gm6634 ENSMUST00000273488.1 Gm6634 (from geneSymbol) AK144724 uc332zmp.1 uc332zmp.1 
ENSMUST00000273512.1 ENSMUSG00000125945 ENSMUST00000273512.1 ENSMUSG00000125945 (from geneSymbol) uc332znn.1 uc332znn.1 
ENSMUST00000273514.1 Gm44238 ENSMUST00000273514.1 Gm44238 (from geneSymbol) uc332znp.1 uc332znp.1 
ENSMUST00000273515.1 ENSMUSG00000125946 ENSMUST00000273515.1 ENSMUSG00000125946 (from geneSymbol) uc332znq.1 uc332znq.1 
ENSMUST00000273516.1 ENSMUSG00000125947 ENSMUST00000273516.1 ENSMUSG00000125947 (from geneSymbol) uc332znr.1 uc332znr.1 
ENSMUST00000273519.1 Gm28402 ENSMUST00000273519.1 Gm28402 (from geneSymbol) uc332znt.1 uc332znt.1 
ENSMUST00000273521.1 Gm26653 ENSMUST00000273521.1 Gm26653 (from geneSymbol) AK042955 uc332znv.1 uc332znv.1 
ENSMUST00000273530.1 Gm42808 ENSMUST00000273530.1 Gm42808 (from geneSymbol) uc332zoe.1 uc332zoe.1 
ENSMUST00000273532.1 ENSMUSG00000125949 ENSMUST00000273532.1 ENSMUSG00000125949 (from geneSymbol) uc332zog.1 uc332zog.1 
ENSMUST00000273533.1 ENSMUSG00000125950 ENSMUST00000273533.1 ENSMUSG00000125950 (from geneSymbol) uc332zoh.1 uc332zoh.1 
ENSMUST00000273540.1 ENSMUSG00000125951 ENSMUST00000273540.1 ENSMUSG00000125951 (from geneSymbol) uc332zoo.1 uc332zoo.1 
ENSMUST00000273541.1 ENSMUSG00000125952 ENSMUST00000273541.1 ENSMUSG00000125952 (from geneSymbol) uc332zop.1 uc332zop.1 
ENSMUST00000273542.1 ENSMUSG00000125953 ENSMUST00000273542.1 ENSMUSG00000125953 (from geneSymbol) uc332zoq.1 uc332zoq.1 
ENSMUST00000273544.1 4930556N09Rik ENSMUST00000273544.1 4930556N09Rik (from geneSymbol) AK016152 uc332zos.1 uc332zos.1 
ENSMUST00000273552.1 ENSMUSG00000125954 ENSMUST00000273552.1 ENSMUSG00000125954 (from geneSymbol) uc332zpa.1 uc332zpa.1 
ENSMUST00000273613.1 Gm46123 ENSMUST00000273613.1 Gm46123 (from geneSymbol) uc332zrg.1 uc332zrg.1 
ENSMUST00000273632.1 ENSMUSG00000125956 ENSMUST00000273632.1 ENSMUSG00000125956 (from geneSymbol) uc332zrz.1 uc332zrz.1 
ENSMUST00000273634.1 ENSMUSG00000125957 ENSMUST00000273634.1 ENSMUSG00000125957 (from geneSymbol) uc332zsb.1 uc332zsb.1 
ENSMUST00000273640.1 A330040F15Rik ENSMUST00000273640.1 A330040F15Rik (from geneSymbol) AK052621 uc332zsh.1 uc332zsh.1 
ENSMUST00000273657.1 ENSMUSG00000125958 ENSMUST00000273657.1 ENSMUSG00000125958 (from geneSymbol) uc332zsx.1 uc332zsx.1 
ENSMUST00000273658.1 ENSMUSG00000125959 ENSMUST00000273658.1 ENSMUSG00000125959 (from geneSymbol) uc332zsy.1 uc332zsy.1 
ENSMUST00000273659.1 C030004G16Rik ENSMUST00000273659.1 C030004G16Rik (from geneSymbol) AK021043 uc332zsz.1 uc332zsz.1 
ENSMUST00000273683.1 ENSMUSG00000125960 ENSMUST00000273683.1 ENSMUSG00000125960 (from geneSymbol) uc332ztx.1 uc332ztx.1 
ENSMUST00000273689.1 ENSMUSG00000125961 ENSMUST00000273689.1 ENSMUSG00000125961 (from geneSymbol) uc332zud.1 uc332zud.1 
ENSMUST00000273691.1 ENSMUSG00000125962 ENSMUST00000273691.1 ENSMUSG00000125962 (from geneSymbol) uc332zuf.1 uc332zuf.1 
ENSMUST00000273694.1 Gm20083 ENSMUST00000273694.1 Gm20083 (from geneSymbol) AK046300 uc332zui.1 uc332zui.1 
ENSMUST00000273714.1 ENSMUSG00000125963 ENSMUST00000273714.1 ENSMUSG00000125963 (from geneSymbol) uc332zvc.1 uc332zvc.1 
ENSMUST00000273717.1 ENSMUSG00000125964 ENSMUST00000273717.1 ENSMUSG00000125964 (from geneSymbol) uc332zvf.1 uc332zvf.1 
ENSMUST00000273720.1 Gm45441 ENSMUST00000273720.1 Gm45441 (from geneSymbol) AK133391 uc332zvi.1 uc332zvi.1 
ENSMUST00000273726.1 ENSMUSG00000125965 ENSMUST00000273726.1 ENSMUSG00000125965 (from geneSymbol) uc332zvo.1 uc332zvo.1 
ENSMUST00000273729.1 ENSMUSG00000125966 ENSMUST00000273729.1 ENSMUSG00000125966 (from geneSymbol) uc332zvr.1 uc332zvr.1 
ENSMUST00000273730.1 ENSMUSG00000125967 ENSMUST00000273730.1 ENSMUSG00000125967 (from geneSymbol) uc332zvs.1 uc332zvs.1 
ENSMUST00000273732.1 ENSMUSG00000125968 ENSMUST00000273732.1 ENSMUSG00000125968 (from geneSymbol) uc332zvu.1 uc332zvu.1 
ENSMUST00000273733.1 Gm20617 ENSMUST00000273733.1 Gm20617 (from geneSymbol) uc332zvv.1 uc332zvv.1 
ENSMUST00000273738.1 ENSMUSG00000125969 ENSMUST00000273738.1 ENSMUSG00000125969 (from geneSymbol) uc332zwa.1 uc332zwa.1 
ENSMUST00000273746.1 ENSMUSG00000125971 ENSMUST00000273746.1 ENSMUSG00000125971 (from geneSymbol) AK019563 uc332zwd.1 uc332zwd.1 
ENSMUST00000273750.1 ENSMUSG00000125972 ENSMUST00000273750.1 ENSMUSG00000125972 (from geneSymbol) uc332zwh.1 uc332zwh.1 
ENSMUST00000273755.1 ENSMUSG00000125973 ENSMUST00000273755.1 ENSMUSG00000125973 (from geneSymbol) uc332zwm.1 uc332zwm.1 
ENSMUST00000273758.1 ENSMUSG00000125974 ENSMUST00000273758.1 ENSMUSG00000125974 (from geneSymbol) uc332zwp.1 uc332zwp.1 
ENSMUST00000273769.1 ENSMUSG00000125975 ENSMUST00000273769.1 ENSMUSG00000125975 (from geneSymbol) uc332zxa.1 uc332zxa.1 
ENSMUST00000273771.1 ENSMUSG00000125976 ENSMUST00000273771.1 ENSMUSG00000125976 (from geneSymbol) uc332zxc.1 uc332zxc.1 
ENSMUST00000273778.1 Gm49926 ENSMUST00000273778.1 Gm49926 (from geneSymbol) uc332zxj.1 uc332zxj.1 
ENSMUST00000273780.1 ENSMUSG00000125977 ENSMUST00000273780.1 ENSMUSG00000125977 (from geneSymbol) uc332zxl.1 uc332zxl.1 
ENSMUST00000273781.1 ENSMUSG00000125978 ENSMUST00000273781.1 ENSMUSG00000125978 (from geneSymbol) AK016733 uc332zxm.1 uc332zxm.1 
ENSMUST00000273785.1 ENSMUSG00000125979 ENSMUST00000273785.1 ENSMUSG00000125979 (from geneSymbol) uc332zxq.1 uc332zxq.1 
ENSMUST00000273786.1 ENSMUSG00000125980 ENSMUST00000273786.1 ENSMUSG00000125980 (from geneSymbol) uc332zxr.1 uc332zxr.1 
ENSMUST00000273787.1 ENSMUSG00000125981 ENSMUST00000273787.1 ENSMUSG00000125981 (from geneSymbol) uc332zxs.1 uc332zxs.1 
ENSMUST00000273788.1 ENSMUSG00000125982 ENSMUST00000273788.1 ENSMUSG00000125982 (from geneSymbol) uc332zxt.1 uc332zxt.1 
ENSMUST00000273793.1 4930593C16Rik ENSMUST00000273793.1 4930593C16Rik (from geneSymbol) AK019838 uc332zxy.1 uc332zxy.1 
ENSMUST00000273804.1 ENSMUSG00000125983 ENSMUST00000273804.1 ENSMUSG00000125983 (from geneSymbol) uc332zyj.1 uc332zyj.1 
ENSMUST00000273805.1 ENSMUSG00000125984 ENSMUST00000273805.1 ENSMUSG00000125984 (from geneSymbol) uc332zyk.1 uc332zyk.1 
ENSMUST00000273807.1 ENSMUSG00000125985 ENSMUST00000273807.1 ENSMUSG00000125985 (from geneSymbol) uc332zym.1 uc332zym.1 
ENSMUST00000273813.1 ENSMUSG00000125986 ENSMUST00000273813.1 ENSMUSG00000125986 (from geneSymbol) uc332zys.1 uc332zys.1 
ENSMUST00000273821.1 Gm30603 ENSMUST00000273821.1 Gm30603 (from geneSymbol) uc332zyz.1 uc332zyz.1 
ENSMUST00000273827.1 ENSMUSG00000125987 ENSMUST00000273827.1 ENSMUSG00000125987 (from geneSymbol) uc332zzf.1 uc332zzf.1 
ENSMUST00000273828.1 ENSMUSG00000125988 ENSMUST00000273828.1 ENSMUSG00000125988 (from geneSymbol) LF195559 uc332zzg.1 uc332zzg.1 
ENSMUST00000273830.1 ENSMUSG00000125989 ENSMUST00000273830.1 ENSMUSG00000125989 (from geneSymbol) uc332zzi.1 uc332zzi.1 
ENSMUST00000273835.1 Gm34426 ENSMUST00000273835.1 Gm34426 (from geneSymbol) uc332zzn.1 uc332zzn.1 
ENSMUST00000273838.1 ENSMUSG00000125990 ENSMUST00000273838.1 ENSMUSG00000125990 (from geneSymbol) uc332zzq.1 uc332zzq.1 
ENSMUST00000273839.1 ENSMUSG00000125991 ENSMUST00000273839.1 ENSMUSG00000125991 (from geneSymbol) uc332zzr.1 uc332zzr.1 
ENSMUST00000273840.1 6430573P05Rik ENSMUST00000273840.1 6430573P05Rik (from geneSymbol) uc332zzs.1 uc332zzs.1 
ENSMUST00000273850.1 ENSMUSG00000125992 ENSMUST00000273850.1 ENSMUSG00000125992 (from geneSymbol) uc333aac.1 uc333aac.1 
ENSMUST00000273854.1 ENSMUSG00000125993 ENSMUST00000273854.1 ENSMUSG00000125993 (from geneSymbol) uc333aag.1 uc333aag.1 
ENSMUST00000273871.1 4122401K19Rik ENSMUST00000273871.1 4122401K19Rik (from geneSymbol) uc333aam.1 uc333aam.1 
ENSMUST00000273875.1 ENSMUSG00000125995 ENSMUST00000273875.1 ENSMUSG00000125995 (from geneSymbol) uc333aaq.1 uc333aaq.1 
ENSMUST00000273876.1 ENSMUSG00000125996 ENSMUST00000273876.1 ENSMUSG00000125996 (from geneSymbol) uc333aar.1 uc333aar.1 
ENSMUST00000273877.1 Gm45282 ENSMUST00000273877.1 Gm45282 (from geneSymbol) uc333aas.1 uc333aas.1 
ENSMUST00000273883.1 ENSMUSG00000125997 ENSMUST00000273883.1 ENSMUSG00000125997 (from geneSymbol) uc333aay.1 uc333aay.1 
ENSMUST00000273890.1 ENSMUSG00000125998 ENSMUST00000273890.1 ENSMUSG00000125998 (from geneSymbol) uc333abf.1 uc333abf.1 
ENSMUST00000273892.1 ENSMUSG00000125999 ENSMUST00000273892.1 ENSMUSG00000125999 (from geneSymbol) uc333abh.1 uc333abh.1 
ENSMUST00000273893.1 ENSMUSG00000126000 ENSMUST00000273893.1 ENSMUSG00000126000 (from geneSymbol) uc333abi.1 uc333abi.1 
ENSMUST00000273895.1 BC106175 ENSMUST00000273895.1 cDNA sequence BC106175, transcript variant 2 (from RefSeq NR_183074.1) NR_183074 uc333abk.1 uc333abk.1 
ENSMUST00000273897.1 ENSMUSG00000126002 ENSMUST00000273897.1 ENSMUSG00000126002 (from geneSymbol) uc333abl.1 uc333abl.1 
ENSMUST00000273898.1 ENSMUSG00000126003 ENSMUST00000273898.1 ENSMUSG00000126003 (from geneSymbol) uc333abm.1 uc333abm.1 
ENSMUST00000273901.1 4930443O20Rik ENSMUST00000273901.1 4930443O20Rik (from geneSymbol) AK015373 uc333abp.1 uc333abp.1 
ENSMUST00000273909.1 ENSMUSG00000126004 ENSMUST00000273909.1 ENSMUSG00000126004 (from geneSymbol) uc333abx.1 uc333abx.1 
ENSMUST00000273911.1 ENSMUSG00000126005 ENSMUST00000273911.1 ENSMUSG00000126005 (from geneSymbol) uc333abz.1 uc333abz.1 
ENSMUST00000273912.1 ENSMUSG00000126006 ENSMUST00000273912.1 ENSMUSG00000126006 (from geneSymbol) uc333aca.1 uc333aca.1 
ENSMUST00000273913.1 ENSMUSG00000126007 ENSMUST00000273913.1 ENSMUSG00000126007 (from geneSymbol) uc333acb.1 uc333acb.1 
ENSMUST00000273914.1 ENSMUSG00000126008 ENSMUST00000273914.1 ENSMUSG00000126008 (from geneSymbol) uc333acc.1 uc333acc.1 
ENSMUST00000273915.1 ENSMUSG00000126009 ENSMUST00000273915.1 ENSMUSG00000126009 (from geneSymbol) uc333acd.1 uc333acd.1 
ENSMUST00000273916.1 ENSMUSG00000126010 ENSMUST00000273916.1 ENSMUSG00000126010 (from geneSymbol) uc333ace.1 uc333ace.1 
ENSMUST00000273917.1 ENSMUSG00000126011 ENSMUST00000273917.1 ENSMUSG00000126011 (from geneSymbol) uc333acf.1 uc333acf.1 
ENSMUST00000273923.1 ENSMUSG00000126012 ENSMUST00000273923.1 ENSMUSG00000126012 (from geneSymbol) uc333acl.1 uc333acl.1 
ENSMUST00000273924.1 ENSMUSG00000126013 ENSMUST00000273924.1 ENSMUSG00000126013 (from geneSymbol) uc333acm.1 uc333acm.1 
ENSMUST00000273925.1 ENSMUSG00000126014 ENSMUST00000273925.1 ENSMUSG00000126014 (from geneSymbol) uc333acn.1 uc333acn.1 
ENSMUST00000273926.1 ENSMUSG00000126015 ENSMUST00000273926.1 ENSMUSG00000126015 (from geneSymbol) uc333aco.1 uc333aco.1 
ENSMUST00000273927.1 ENSMUSG00000126016 ENSMUST00000273927.1 ENSMUSG00000126016 (from geneSymbol) uc333acp.1 uc333acp.1 
ENSMUST00000273928.1 ENSMUSG00000126017 ENSMUST00000273928.1 ENSMUSG00000126017 (from geneSymbol) uc333acq.1 uc333acq.1 
ENSMUST00000273929.1 ENSMUSG00000126018 ENSMUST00000273929.1 ENSMUSG00000126018 (from geneSymbol) uc333acr.1 uc333acr.1 
ENSMUST00000273933.1 ENSMUSG00000126020 ENSMUST00000273933.1 ENSMUSG00000126020 (from geneSymbol) uc333acs.1 uc333acs.1 
ENSMUST00000273943.1 ENSMUSG00000126021 ENSMUST00000273943.1 ENSMUSG00000126021 (from geneSymbol) uc333adc.1 uc333adc.1 
ENSMUST00000273947.1 ENSMUSG00000126022 ENSMUST00000273947.1 ENSMUSG00000126022 (from geneSymbol) uc333adg.1 uc333adg.1 
ENSMUST00000273948.1 ENSMUSG00000126023 ENSMUST00000273948.1 ENSMUSG00000126023 (from geneSymbol) uc333adh.1 uc333adh.1 
ENSMUST00000273965.1 ENSMUSG00000126024 ENSMUST00000273965.1 ENSMUSG00000126024 (from geneSymbol) uc333ady.1 uc333ady.1 
ENSMUST00000273968.1 Gm39859 ENSMUST00000273968.1 Gm39859 (from geneSymbol) KY467875 uc333aeb.1 uc333aeb.1 
ENSMUST00000273978.1 ENSMUSG00000126025 ENSMUST00000273978.1 ENSMUSG00000126025 (from geneSymbol) uc333ael.1 uc333ael.1 
ENSMUST00000273979.1 ENSMUSG00000126026 ENSMUST00000273979.1 ENSMUSG00000126026 (from geneSymbol) uc333aem.1 uc333aem.1 
ENSMUST00000273985.1 ENSMUSG00000126027 ENSMUST00000273985.1 ENSMUSG00000126027 (from geneSymbol) uc333aes.1 uc333aes.1 
ENSMUST00000273990.1 ENSMUSG00000126028 ENSMUST00000273990.1 ENSMUSG00000126028 (from geneSymbol) uc333aex.1 uc333aex.1 
ENSMUST00000273996.1 ENSMUSG00000126029 ENSMUST00000273996.1 ENSMUSG00000126029 (from geneSymbol) uc333afd.1 uc333afd.1 
ENSMUST00000273999.1 ENSMUSG00000126030 ENSMUST00000273999.1 ENSMUSG00000126030 (from geneSymbol) uc333aff.1 uc333aff.1 
ENSMUST00000274012.1 ENSMUSG00000126031 ENSMUST00000274012.1 ENSMUSG00000126031 (from geneSymbol) uc333afs.1 uc333afs.1 
ENSMUST00000274014.1 ENSMUSG00000126032 ENSMUST00000274014.1 ENSMUSG00000126032 (from geneSymbol) uc333aft.1 uc333aft.1 
ENSMUST00000274015.1 ENSMUSG00000126033 ENSMUST00000274015.1 ENSMUSG00000126033 (from geneSymbol) uc333afu.1 uc333afu.1 
ENSMUST00000274017.1 Gm38593 ENSMUST00000274017.1 predicted gene, 38593, transcript variant 1 (from RefSeq NR_172506.1) NR_172506 uc333afw.1 uc333afw.1 
ENSMUST00000274019.1 Gm2087 ENSMUST00000274019.1 Gm2087 (from geneSymbol) AK076672 uc333afy.1 uc333afy.1 
ENSMUST00000274021.1 ENSMUSG00000126034 ENSMUST00000274021.1 ENSMUSG00000126034 (from geneSymbol) uc333aga.1 uc333aga.1 
ENSMUST00000274024.1 ENSMUSG00000126035 ENSMUST00000274024.1 ENSMUSG00000126035 (from geneSymbol) uc333agd.1 uc333agd.1 
ENSMUST00000274071.1 ENSMUSG00000126036 ENSMUST00000274071.1 ENSMUSG00000126036 (from geneSymbol) uc333ahy.1 uc333ahy.1 
ENSMUST00000274076.1 4930447N08Rik ENSMUST00000274076.1 4930447N08Rik (from geneSymbol) AK015409 uc333aid.1 uc333aid.1 
ENSMUST00000274086.1 ENSMUSG00000126037 ENSMUST00000274086.1 ENSMUSG00000126037 (from geneSymbol) uc333ain.1 uc333ain.1 
ENSMUST00000274088.1 ENSMUSG00000126038 ENSMUST00000274088.1 ENSMUSG00000126038 (from geneSymbol) uc333aip.1 uc333aip.1 
ENSMUST00000274107.1 ENSMUSG00000126039 ENSMUST00000274107.1 ENSMUSG00000126039 (from geneSymbol) uc333ajh.1 uc333ajh.1 
ENSMUST00000274110.1 ENSMUSG00000126040 ENSMUST00000274110.1 ENSMUSG00000126040 (from geneSymbol) uc333ajk.1 uc333ajk.1 
ENSMUST00000274112.1 ENSMUSG00000126042 ENSMUST00000274112.1 ENSMUSG00000126042 (from geneSymbol) uc333ajl.1 uc333ajl.1 
ENSMUST00000274115.1 ENSMUSG00000126043 ENSMUST00000274115.1 ENSMUSG00000126043 (from geneSymbol) uc333ajo.1 uc333ajo.1 
ENSMUST00000274117.1 ENSMUSG00000126044 ENSMUST00000274117.1 ENSMUSG00000126044 (from geneSymbol) uc333ajq.1 uc333ajq.1 
ENSMUST00000274121.1 Gm35299 ENSMUST00000274121.1 Gm35299 (from geneSymbol) uc333aju.1 uc333aju.1 
ENSMUST00000274131.1 Gm41031 ENSMUST00000274131.1 Gm41031 (from geneSymbol) AK030468 uc333ake.1 uc333ake.1 
ENSMUST00000274139.1 ENSMUSG00000126045 ENSMUST00000274139.1 ENSMUSG00000126045 (from geneSymbol) uc333akl.1 uc333akl.1 
ENSMUST00000274140.1 ENSMUSG00000126046 ENSMUST00000274140.1 ENSMUSG00000126046 (from geneSymbol) AK135441 uc333akm.1 uc333akm.1 
ENSMUST00000274145.1 ENSMUSG00000126048 ENSMUST00000274145.1 ENSMUSG00000126048 (from geneSymbol) uc333ako.1 uc333ako.1 
ENSMUST00000274146.1 ENSMUSG00000126049 ENSMUST00000274146.1 ENSMUSG00000126049 (from geneSymbol) uc333akp.1 uc333akp.1 
ENSMUST00000274149.1 ENSMUSG00000126050 ENSMUST00000274149.1 ENSMUSG00000126050 (from geneSymbol) uc333aks.1 uc333aks.1 
ENSMUST00000274150.1 ENSMUSG00000126051 ENSMUST00000274150.1 ENSMUSG00000126051 (from geneSymbol) uc333akt.1 uc333akt.1 
ENSMUST00000274158.1 ENSMUSG00000126052 ENSMUST00000274158.1 ENSMUSG00000126052 (from geneSymbol) uc333alb.1 uc333alb.1 
ENSMUST00000274159.1 ENSMUSG00000126053 ENSMUST00000274159.1 ENSMUSG00000126053 (from geneSymbol) uc333alc.1 uc333alc.1 
ENSMUST00000274160.1 ENSMUSG00000126054 ENSMUST00000274160.1 ENSMUSG00000126054 (from geneSymbol) uc333ald.1 uc333ald.1 
ENSMUST00000274161.1 ENSMUSG00000126055 ENSMUST00000274161.1 ENSMUSG00000126055 (from geneSymbol) uc333ale.1 uc333ale.1 
ENSMUST00000274162.1 ENSMUSG00000126056 ENSMUST00000274162.1 ENSMUSG00000126056 (from geneSymbol) uc333alf.1 uc333alf.1 
ENSMUST00000274163.1 ENSMUSG00000126057 ENSMUST00000274163.1 ENSMUSG00000126057 (from geneSymbol) uc333alg.1 uc333alg.1 
ENSMUST00000274165.1 ENSMUSG00000126058 ENSMUST00000274165.1 ENSMUSG00000126058 (from geneSymbol) uc333ali.1 uc333ali.1 
ENSMUST00000274166.1 ENSMUSG00000126059 ENSMUST00000274166.1 ENSMUSG00000126059 (from geneSymbol) uc333alj.1 uc333alj.1 
ENSMUST00000274171.1 Arl4aos ENSMUST00000274171.1 Arl4aos (from geneSymbol) KY467636 uc333alo.1 uc333alo.1 
ENSMUST00000274189.1 ENSMUSG00000126060 ENSMUST00000274189.1 ENSMUSG00000126060 (from geneSymbol) uc333amg.1 uc333amg.1 
ENSMUST00000274241.1 ENSMUSG00000126062 ENSMUST00000274241.1 ENSMUSG00000126062 (from geneSymbol) uc333aog.1 uc333aog.1 
ENSMUST00000274242.1 ENSMUSG00000126061 ENSMUST00000274242.1 ENSMUSG00000126061 (from geneSymbol) uc333aoh.1 uc333aoh.1 
ENSMUST00000274245.1 ENSMUSG00000126063 ENSMUST00000274245.1 ENSMUSG00000126063 (from geneSymbol) uc333aok.1 uc333aok.1 
ENSMUST00000274247.1 Gm13589 ENSMUST00000274247.1 Gm13589 (from geneSymbol) AK163151 uc333aol.1 uc333aol.1 
ENSMUST00000274254.1 ENSMUSG00000126064 ENSMUST00000274254.1 ENSMUSG00000126064 (from geneSymbol) uc333aos.1 uc333aos.1 
ENSMUST00000274255.1 Gm4117 ENSMUST00000274255.1 Gm4117 (from geneSymbol) AK040967 uc333aot.1 uc333aot.1 
ENSMUST00000274257.1 Gm56646 ENSMUST00000274257.1 Gm56646 (from geneSymbol) uc333aou.1 uc333aou.1 
ENSMUST00000274263.1 ENSMUSG00000126065 ENSMUST00000274263.1 ENSMUSG00000126065 (from geneSymbol) uc333apa.1 uc333apa.1 
ENSMUST00000274266.1 ENSMUSG00000126066 ENSMUST00000274266.1 ENSMUSG00000126066 (from geneSymbol) uc333apd.1 uc333apd.1 
ENSMUST00000274272.1 ENSMUSG00000126067 ENSMUST00000274272.1 ENSMUSG00000126067 (from geneSymbol) uc333apj.1 uc333apj.1 
ENSMUST00000274277.1 ENSMUSG00000126068 ENSMUST00000274277.1 ENSMUSG00000126068 (from geneSymbol) uc333apo.1 uc333apo.1 
ENSMUST00000274278.1 ENSMUSG00000126069 ENSMUST00000274278.1 ENSMUSG00000126069 (from geneSymbol) uc333app.1 uc333app.1 
ENSMUST00000274280.1 ENSMUSG00000126070 ENSMUST00000274280.1 ENSMUSG00000126070 (from geneSymbol) uc333apr.1 uc333apr.1 
ENSMUST00000274281.1 ENSMUSG00000126071 ENSMUST00000274281.1 ENSMUSG00000126071 (from geneSymbol) uc333aps.1 uc333aps.1 
ENSMUST00000274285.1 ENSMUSG00000126072 ENSMUST00000274285.1 ENSMUSG00000126072 (from geneSymbol) uc333apw.1 uc333apw.1 
ENSMUST00000274287.1 Gm14902 ENSMUST00000274287.1 Gm14902 (from geneSymbol) AK085872 uc333apy.1 uc333apy.1 
ENSMUST00000274292.1 ENSMUSG00000126073 ENSMUST00000274292.1 ENSMUSG00000126073 (from geneSymbol) uc333aqd.1 uc333aqd.1 
ENSMUST00000274294.1 ENSMUSG00000126074 ENSMUST00000274294.1 ENSMUSG00000126074 (from geneSymbol) uc333aqf.1 uc333aqf.1 
ENSMUST00000274295.1 ENSMUSG00000126075 ENSMUST00000274295.1 ENSMUSG00000126075 (from geneSymbol) uc333aqg.1 uc333aqg.1 
ENSMUST00000274296.1 ENSMUSG00000126076 ENSMUST00000274296.1 ENSMUSG00000126076 (from geneSymbol) uc333aqh.1 uc333aqh.1 
ENSMUST00000274298.1 ENSMUSG00000126077 ENSMUST00000274298.1 ENSMUSG00000126077 (from geneSymbol) uc333aqj.1 uc333aqj.1 
ENSMUST00000274308.1 ENSMUSG00000126078 ENSMUST00000274308.1 ENSMUSG00000126078 (from geneSymbol) uc333aqs.1 uc333aqs.1 
ENSMUST00000274309.1 ENSMUSG00000126079 ENSMUST00000274309.1 ENSMUSG00000126079 (from geneSymbol) uc333aqt.1 uc333aqt.1 
ENSMUST00000274313.1 ENSMUSG00000126080 ENSMUST00000274313.1 ENSMUSG00000126080 (from geneSymbol) uc333aqx.1 uc333aqx.1 
ENSMUST00000274315.1 ENSMUSG00000126081 ENSMUST00000274315.1 ENSMUSG00000126081 (from geneSymbol) uc333aqy.1 uc333aqy.1 
ENSMUST00000274316.1 Gm14437 ENSMUST00000274316.1 predicted gene 14437, transcript variant 2 (from RefSeq NR_166416.1) NR_166416 uc333aqz.1 uc333aqz.1 
ENSMUST00000274318.1 ENSMUSG00000126082 ENSMUST00000274318.1 ENSMUSG00000126082 (from geneSymbol) uc333arb.1 uc333arb.1 
ENSMUST00000274320.1 ENSMUSG00000126083 ENSMUST00000274320.1 ENSMUSG00000126083 (from geneSymbol) uc333ard.1 uc333ard.1 
ENSMUST00000274321.1 ENSMUSG00000126084 ENSMUST00000274321.1 ENSMUSG00000126084 (from geneSymbol) uc333are.1 uc333are.1 
ENSMUST00000274324.1 Gm30963 ENSMUST00000274324.1 predicted gene, 30963 (from RefSeq NR_155765.1) NR_155765 uc333arh.1 uc333arh.1 
ENSMUST00000274329.1 Gm56669 ENSMUST00000274329.1 Gm56669 (from geneSymbol) uc333arm.1 uc333arm.1 
ENSMUST00000274332.1 ENSMUSG00000126085 ENSMUST00000274332.1 ENSMUSG00000126085 (from geneSymbol) uc333arp.1 uc333arp.1 
ENSMUST00000274343.1 ENSMUSG00000126086 ENSMUST00000274343.1 ENSMUSG00000126086 (from geneSymbol) uc333asa.1 uc333asa.1 
ENSMUST00000274356.1 ENSMUSG00000126087 ENSMUST00000274356.1 ENSMUSG00000126087 (from geneSymbol) uc333asm.1 uc333asm.1 
ENSMUST00000274360.1 Gm20522 ENSMUST00000274360.1 predicted gene 20522, transcript variant 1 (from RefSeq NR_168268.1) NR_168268 uc333asq.1 uc333asq.1 
ENSMUST00000274363.1 ENSMUSG00000126088 ENSMUST00000274363.1 ENSMUSG00000126088 (from geneSymbol) uc333ast.1 uc333ast.1 
ENSMUST00000274364.1 ENSMUSG00000126089 ENSMUST00000274364.1 ENSMUSG00000126089 (from geneSymbol) uc333asu.1 uc333asu.1 
ENSMUST00000274367.1 ENSMUSG00000126090 ENSMUST00000274367.1 ENSMUSG00000126090 (from geneSymbol) uc333asx.1 uc333asx.1 
ENSMUST00000274378.1 ENSMUSG00000126091 ENSMUST00000274378.1 ENSMUSG00000126091 (from geneSymbol) uc333ati.1 uc333ati.1 
ENSMUST00000274379.1 ENSMUSG00000126092 ENSMUST00000274379.1 ENSMUSG00000126092 (from geneSymbol) uc333atj.1 uc333atj.1 
ENSMUST00000274381.1 ENSMUSG00000126093 ENSMUST00000274381.1 ENSMUSG00000126093 (from geneSymbol) uc333atl.1 uc333atl.1 
ENSMUST00000274382.1 ENSMUSG00000126094 ENSMUST00000274382.1 ENSMUSG00000126094 (from geneSymbol) uc333atm.1 uc333atm.1 
ENSMUST00000274383.1 ENSMUSG00000126095 ENSMUST00000274383.1 ENSMUSG00000126095 (from geneSymbol) uc333atn.1 uc333atn.1 
ENSMUST00000274385.1 ENSMUSG00000126096 ENSMUST00000274385.1 ENSMUSG00000126096 (from geneSymbol) uc333atp.1 uc333atp.1 
ENSMUST00000274386.1 ENSMUSG00000126097 ENSMUST00000274386.1 ENSMUSG00000126097 (from geneSymbol) uc333atq.1 uc333atq.1 
ENSMUST00000274387.1 ENSMUSG00000126098 ENSMUST00000274387.1 ENSMUSG00000126098 (from geneSymbol) uc333atr.1 uc333atr.1 
ENSMUST00000274389.1 ENSMUSG00000126099 ENSMUST00000274389.1 ENSMUSG00000126099 (from geneSymbol) uc333att.1 uc333att.1 
ENSMUST00000274390.1 ENSMUSG00000126100 ENSMUST00000274390.1 ENSMUSG00000126100 (from geneSymbol) uc333atu.1 uc333atu.1 
ENSMUST00000274391.1 Gm41545 ENSMUST00000274391.1 Gm41545 (from geneSymbol) uc333atv.1 uc333atv.1 
ENSMUST00000274392.1 ENSMUSG00000126101 ENSMUST00000274392.1 ENSMUSG00000126101 (from geneSymbol) uc333atw.1 uc333atw.1 
ENSMUST00000274393.1 ENSMUSG00000126102 ENSMUST00000274393.1 ENSMUSG00000126102 (from geneSymbol) uc333atx.1 uc333atx.1 
ENSMUST00000274395.1 ENSMUSG00000126103 ENSMUST00000274395.1 ENSMUSG00000126103 (from geneSymbol) uc333atz.1 uc333atz.1 
ENSMUST00000274403.1 ENSMUSG00000126104 ENSMUST00000274403.1 ENSMUSG00000126104 (from geneSymbol) uc333auh.1 uc333auh.1 
ENSMUST00000274404.1 ENSMUSG00000126105 ENSMUST00000274404.1 ENSMUSG00000126105 (from geneSymbol) uc333aui.1 uc333aui.1 
ENSMUST00000274405.1 ENSMUSG00000126106 ENSMUST00000274405.1 ENSMUSG00000126106 (from geneSymbol) uc333auj.1 uc333auj.1 
ENSMUST00000274407.1 ENSMUSG00000126107 ENSMUST00000274407.1 ENSMUSG00000126107 (from geneSymbol) uc333aul.1 uc333aul.1 
ENSMUST00000274409.1 Gm49046 ENSMUST00000274409.1 Gm49046 (from geneSymbol) uc333aun.1 uc333aun.1 
ENSMUST00000274416.1 ENSMUSG00000126108 ENSMUST00000274416.1 ENSMUSG00000126108 (from geneSymbol) uc333auu.1 uc333auu.1 
ENSMUST00000274417.1 ENSMUSG00000126109 ENSMUST00000274417.1 ENSMUSG00000126109 (from geneSymbol) uc333auv.1 uc333auv.1 
ENSMUST00000274420.1 ENSMUSG00000126110 ENSMUST00000274420.1 ENSMUSG00000126110 (from geneSymbol) uc333auy.1 uc333auy.1 
ENSMUST00000274422.1 ENSMUSG00000126111 ENSMUST00000274422.1 ENSMUSG00000126111 (from geneSymbol) uc333ava.1 uc333ava.1 
ENSMUST00000274425.1 ENSMUSG00000126112 ENSMUST00000274425.1 ENSMUSG00000126112 (from geneSymbol) uc333avd.1 uc333avd.1 
ENSMUST00000274426.1 ENSMUSG00000126113 ENSMUST00000274426.1 ENSMUSG00000126113 (from geneSymbol) AK132522 uc333ave.1 uc333ave.1 
ENSMUST00000274427.1 ENSMUSG00000126114 ENSMUST00000274427.1 ENSMUSG00000126114 (from geneSymbol) uc333avf.1 uc333avf.1 
ENSMUST00000274431.1 ENSMUSG00000126115 ENSMUST00000274431.1 ENSMUSG00000126115 (from geneSymbol) uc333avj.1 uc333avj.1 
ENSMUST00000274437.1 Gm40003 ENSMUST00000274437.1 Gm40003 (from geneSymbol) AK081655 uc333avp.1 uc333avp.1 
ENSMUST00000274438.1 ENSMUSG00000126116 ENSMUST00000274438.1 ENSMUSG00000126116 (from geneSymbol) uc333avq.1 uc333avq.1 
ENSMUST00000274444.1 ENSMUSG00000126117 ENSMUST00000274444.1 ENSMUSG00000126117 (from geneSymbol) uc333avw.1 uc333avw.1 
ENSMUST00000274447.1 ENSMUSG00000126118 ENSMUST00000274447.1 ENSMUSG00000126118 (from geneSymbol) BC087891 uc333avz.1 uc333avz.1 
ENSMUST00000274450.1 ENSMUSG00000126120 ENSMUST00000274450.1 ENSMUSG00000126120 (from geneSymbol) uc333awa.1 uc333awa.1 
ENSMUST00000274451.1 Gm56759 ENSMUST00000274451.1 Gm56759 (from geneSymbol) uc333awb.1 uc333awb.1 
ENSMUST00000274469.1 ENSMUSG00000126121 ENSMUST00000274469.1 ENSMUSG00000126121 (from geneSymbol) uc333awt.1 uc333awt.1 
ENSMUST00000274470.1 ENSMUSG00000126122 ENSMUST00000274470.1 ENSMUSG00000126122 (from geneSymbol) uc333awu.1 uc333awu.1 
ENSMUST00000274487.1 ENSMUSG00000126123 ENSMUST00000274487.1 ENSMUSG00000126123 (from geneSymbol) uc333axl.1 uc333axl.1 
ENSMUST00000274488.1 ENSMUSG00000126124 ENSMUST00000274488.1 ENSMUSG00000126124 (from geneSymbol) uc333axm.1 uc333axm.1 
ENSMUST00000274489.1 Gm17225 ENSMUST00000274489.1 Gm17225 (from geneSymbol) AK138638 uc333axn.1 uc333axn.1 
ENSMUST00000274527.1 ENSMUSG00000126125 ENSMUST00000274527.1 ENSMUSG00000126125 (from geneSymbol) uc333ayy.1 uc333ayy.1 
ENSMUST00000274528.1 ENSMUSG00000126126 ENSMUST00000274528.1 ENSMUSG00000126126 (from geneSymbol) uc333ayz.1 uc333ayz.1 
ENSMUST00000274531.1 Gm57461 ENSMUST00000274531.1 Gm57461 (from geneSymbol) uc333azc.1 uc333azc.1 
ENSMUST00000274533.1 ENSMUSG00000126127 ENSMUST00000274533.1 ENSMUSG00000126127 (from geneSymbol) uc333aze.1 uc333aze.1 
ENSMUST00000274541.1 ENSMUSG00000126128 ENSMUST00000274541.1 ENSMUSG00000126128 (from geneSymbol) uc333azm.1 uc333azm.1 
ENSMUST00000274543.1 ENSMUSG00000126129 ENSMUST00000274543.1 ENSMUSG00000126129 (from geneSymbol) uc333azo.1 uc333azo.1 
ENSMUST00000274544.1 A730043L09Rik ENSMUST00000274544.1 A730043L09Rik (from geneSymbol) uc333azp.1 uc333azp.1 
ENSMUST00000274548.1 ENSMUSG00000126130 ENSMUST00000274548.1 ENSMUSG00000126130 (from geneSymbol) uc333azt.1 uc333azt.1 
ENSMUST00000274549.1 ENSMUSG00000126131 ENSMUST00000274549.1 ENSMUSG00000126131 (from geneSymbol) uc333azu.1 uc333azu.1 
ENSMUST00000274550.1 ENSMUSG00000126132 ENSMUST00000274550.1 ENSMUSG00000126132 (from geneSymbol) uc333azv.1 uc333azv.1 
ENSMUST00000274551.1 ENSMUSG00000126133 ENSMUST00000274551.1 ENSMUSG00000126133 (from geneSymbol) uc333azw.1 uc333azw.1 
ENSMUST00000274552.1 Gm26947 ENSMUST00000274552.1 Gm26947 (from geneSymbol) uc333azx.1 uc333azx.1 
ENSMUST00000274594.1 ENSMUSG00000126134 ENSMUST00000274594.1 ENSMUSG00000126134 (from geneSymbol) uc333bbn.1 uc333bbn.1 
ENSMUST00000274597.1 ENSMUSG00000126135 ENSMUST00000274597.1 ENSMUSG00000126135 (from geneSymbol) uc333bbq.1 uc333bbq.1 
ENSMUST00000274601.1 ENSMUSG00000126136 ENSMUST00000274601.1 ENSMUSG00000126136 (from geneSymbol) uc333bbu.1 uc333bbu.1 
ENSMUST00000274604.1 ENSMUSG00000126137 ENSMUST00000274604.1 ENSMUSG00000126137 (from geneSymbol) uc333bbx.1 uc333bbx.1 
ENSMUST00000274610.1 ENSMUSG00000126139 ENSMUST00000274610.1 ENSMUSG00000126139 (from geneSymbol) uc333bby.1 uc333bby.1 
ENSMUST00000274611.1 ENSMUSG00000126140 ENSMUST00000274611.1 ENSMUSG00000126140 (from geneSymbol) uc333bbz.1 uc333bbz.1 
ENSMUST00000274613.1 ENSMUSG00000126141 ENSMUST00000274613.1 ENSMUSG00000126141 (from geneSymbol) uc333bcb.1 uc333bcb.1 
ENSMUST00000274614.1 ENSMUSG00000126142 ENSMUST00000274614.1 ENSMUSG00000126142 (from geneSymbol) uc333bcc.1 uc333bcc.1 
ENSMUST00000274620.1 ENSMUSG00000126143 ENSMUST00000274620.1 ENSMUSG00000126143 (from geneSymbol) uc333bci.1 uc333bci.1 
ENSMUST00000274621.1 ENSMUSG00000126144 ENSMUST00000274621.1 ENSMUSG00000126144 (from geneSymbol) uc333bcj.1 uc333bcj.1 
ENSMUST00000274622.1 ENSMUSG00000126145 ENSMUST00000274622.1 ENSMUSG00000126145 (from geneSymbol) uc333bck.1 uc333bck.1 
ENSMUST00000274623.1 ENSMUSG00000126146 ENSMUST00000274623.1 ENSMUSG00000126146 (from geneSymbol) uc333bcl.1 uc333bcl.1 
ENSMUST00000274624.1 4930563F08Rik ENSMUST00000274624.1 4930563F08Rik (from geneSymbol) AK016203 uc333bcm.1 uc333bcm.1 
ENSMUST00000274625.1 ENSMUSG00000126147 ENSMUST00000274625.1 ENSMUSG00000126147 (from geneSymbol) uc333bcn.1 uc333bcn.1 
ENSMUST00000274626.1 ENSMUSG00000126148 ENSMUST00000274626.1 ENSMUSG00000126148 (from geneSymbol) uc333bco.1 uc333bco.1 
ENSMUST00000274631.1 Gm13267 ENSMUST00000274631.1 Gm13267 (from geneSymbol) uc333bct.1 uc333bct.1 
ENSMUST00000274659.1 ENSMUSG00000126149 ENSMUST00000274659.1 ENSMUSG00000126149 (from geneSymbol) uc333bdv.1 uc333bdv.1 
ENSMUST00000274660.1 ENSMUSG00000126150 ENSMUST00000274660.1 ENSMUSG00000126150 (from geneSymbol) uc333bdw.1 uc333bdw.1 
ENSMUST00000274672.1 ENSMUSG00000126151 ENSMUST00000274672.1 ENSMUSG00000126151 (from geneSymbol) AK090383 uc333bei.1 uc333bei.1 
ENSMUST00000274674.1 ENSMUSG00000126152 ENSMUST00000274674.1 ENSMUSG00000126152 (from geneSymbol) uc333bek.1 uc333bek.1 
ENSMUST00000274679.1 Gm56573 ENSMUST00000274679.1 Gm56573 (from geneSymbol) uc333beo.1 uc333beo.1 
ENSMUST00000274710.1 ENSMUSG00000126153 ENSMUST00000274710.1 ENSMUSG00000126153 (from geneSymbol) uc333bft.1 uc333bft.1 
ENSMUST00000274711.1 ENSMUSG00000126154 ENSMUST00000274711.1 ENSMUSG00000126154 (from geneSymbol) uc333bfu.1 uc333bfu.1 
ENSMUST00000274712.1 ENSMUSG00000126155 ENSMUST00000274712.1 ENSMUSG00000126155 (from geneSymbol) uc333bfv.1 uc333bfv.1 
ENSMUST00000274717.1 ENSMUSG00000126156 ENSMUST00000274717.1 predicted gene, 35932, transcript variant 3 (from RefSeq NR_168666.1) NR_168666 uc333bga.1 uc333bga.1 
ENSMUST00000274725.1 Gm31513 ENSMUST00000274725.1 Gm31513 (from geneSymbol) uc333bgi.1 uc333bgi.1 
ENSMUST00000274726.1 ENSMUSG00000126157 ENSMUST00000274726.1 ENSMUSG00000126157 (from geneSymbol) uc333bgj.1 uc333bgj.1 
ENSMUST00000274728.1 ENSMUSG00000126158 ENSMUST00000274728.1 ENSMUSG00000126158 (from geneSymbol) uc333bgl.1 uc333bgl.1 
ENSMUST00000274736.1 ENSMUSG00000126159 ENSMUST00000274736.1 ENSMUSG00000126159 (from geneSymbol) uc333bgt.1 uc333bgt.1 
ENSMUST00000274741.1 ENSMUSG00000126160 ENSMUST00000274741.1 ENSMUSG00000126160 (from geneSymbol) uc333bgy.1 uc333bgy.1 
ENSMUST00000274742.1 ENSMUSG00000126161 ENSMUST00000274742.1 ENSMUSG00000126161 (from geneSymbol) uc333bgz.1 uc333bgz.1 
ENSMUST00000274748.1 ENSMUSG00000126162 ENSMUST00000274748.1 ENSMUSG00000126162 (from geneSymbol) uc333bhf.1 uc333bhf.1 
ENSMUST00000274749.1 ENSMUSG00000126163 ENSMUST00000274749.1 ENSMUSG00000126163 (from geneSymbol) uc333bhg.1 uc333bhg.1 
ENSMUST00000274753.1 5033426E14Rik ENSMUST00000274753.1 5033426E14Rik (from geneSymbol) uc333bhj.1 uc333bhj.1 
ENSMUST00000274755.1 ENSMUSG00000126164 ENSMUST00000274755.1 ENSMUSG00000126164 (from geneSymbol) uc333bhl.1 uc333bhl.1 
ENSMUST00000274756.1 ENSMUSG00000126165 ENSMUST00000274756.1 ENSMUSG00000126165 (from geneSymbol) uc333bhm.1 uc333bhm.1 
ENSMUST00000274783.1 ENSMUSG00000126166 ENSMUST00000274783.1 ENSMUSG00000126166 (from geneSymbol) uc333bin.1 uc333bin.1 
ENSMUST00000274785.1 ENSMUSG00000126167 ENSMUST00000274785.1 ENSMUSG00000126167 (from geneSymbol) uc333bip.1 uc333bip.1 
ENSMUST00000274786.1 ENSMUSG00000126168 ENSMUST00000274786.1 ENSMUSG00000126168 (from geneSymbol) uc333biq.1 uc333biq.1 
ENSMUST00000274788.1 ENSMUSG00000126169 ENSMUST00000274788.1 ENSMUSG00000126169 (from geneSymbol) uc333bis.1 uc333bis.1 
ENSMUST00000274789.1 ENSMUSG00000126170 ENSMUST00000274789.1 ENSMUSG00000126170 (from geneSymbol) uc333bit.1 uc333bit.1 
ENSMUST00000274790.1 ENSMUSG00000126171 ENSMUST00000274790.1 ENSMUSG00000126171 (from geneSymbol) uc333biu.1 uc333biu.1 
ENSMUST00000274791.1 Gm47851 ENSMUST00000274791.1 Gm47851 (from geneSymbol) uc333biv.1 uc333biv.1 
ENSMUST00000274792.1 ENSMUSG00000126172 ENSMUST00000274792.1 ENSMUSG00000126172 (from geneSymbol) uc333biw.1 uc333biw.1 
ENSMUST00000274793.1 ENSMUSG00000126173 ENSMUST00000274793.1 ENSMUSG00000126173 (from geneSymbol) uc333bix.1 uc333bix.1 
ENSMUST00000274794.1 ENSMUSG00000126174 ENSMUST00000274794.1 ENSMUSG00000126174 (from geneSymbol) uc333biy.1 uc333biy.1 
ENSMUST00000274805.1 ENSMUSG00000126175 ENSMUST00000274805.1 ENSMUSG00000126175 (from geneSymbol) uc333bjj.1 uc333bjj.1 
ENSMUST00000274806.1 ENSMUSG00000126176 ENSMUST00000274806.1 ENSMUSG00000126176 (from geneSymbol) uc333bjk.1 uc333bjk.1 
ENSMUST00000274809.1 ENSMUSG00000126177 ENSMUST00000274809.1 ENSMUSG00000126177 (from geneSymbol) uc333bjn.1 uc333bjn.1 
ENSMUST00000274810.1 ENSMUSG00000126178 ENSMUST00000274810.1 ENSMUSG00000126178 (from geneSymbol) uc333bjo.1 uc333bjo.1 
ENSMUST00000274812.1 ENSMUSG00000126179 ENSMUST00000274812.1 ENSMUSG00000126179 (from geneSymbol) uc333bjq.1 uc333bjq.1 
ENSMUST00000274813.1 Gm42901 ENSMUST00000274813.1 Gm42901 (from geneSymbol) uc333bjr.1 uc333bjr.1 
ENSMUST00000274822.1 ENSMUSG00000126180 ENSMUST00000274822.1 ENSMUSG00000126180 (from geneSymbol) uc333bka.1 uc333bka.1 
ENSMUST00000274828.1 ENSMUSG00000126181 ENSMUST00000274828.1 ENSMUSG00000126181 (from geneSymbol) uc333bkg.1 uc333bkg.1 
ENSMUST00000274829.1 ENSMUSG00000126182 ENSMUST00000274829.1 ENSMUSG00000126182 (from geneSymbol) uc333bkh.1 uc333bkh.1 
ENSMUST00000274830.1 ENSMUSG00000126183 ENSMUST00000274830.1 ENSMUSG00000126183 (from geneSymbol) uc333bki.1 uc333bki.1 
ENSMUST00000274833.1 ENSMUSG00000126184 ENSMUST00000274833.1 ENSMUSG00000126184 (from geneSymbol) uc333bkl.1 uc333bkl.1 
ENSMUST00000274835.1 ENSMUSG00000126185 ENSMUST00000274835.1 ENSMUSG00000126185 (from geneSymbol) uc333bkn.1 uc333bkn.1 
ENSMUST00000274836.1 ENSMUSG00000126186 ENSMUST00000274836.1 ENSMUSG00000126186 (from geneSymbol) uc333bko.1 uc333bko.1 
ENSMUST00000274900.1 Gm27040 ENSMUST00000274900.1 Gm27040 (from geneSymbol) uc333bna.1 uc333bna.1 
ENSMUST00000274920.1 ENSMUSG00000126187 ENSMUST00000274920.1 ENSMUSG00000126187 (from geneSymbol) uc333bnu.1 uc333bnu.1 
ENSMUST00000274921.1 ENSMUSG00000126188 ENSMUST00000274921.1 ENSMUSG00000126188 (from geneSymbol) uc333bnv.1 uc333bnv.1 
ENSMUST00000274922.1 ENSMUSG00000126189 ENSMUST00000274922.1 ENSMUSG00000126189 (from geneSymbol) uc333bnw.1 uc333bnw.1 
ENSMUST00000274923.1 Gm57323 ENSMUST00000274923.1 Gm57323 (from geneSymbol) uc333bnx.1 uc333bnx.1 
ENSMUST00000274926.1 ENSMUSG00000126190 ENSMUST00000274926.1 ENSMUSG00000126190 (from geneSymbol) uc333boa.1 uc333boa.1 
ENSMUST00000274930.1 ENSMUSG00000126191 ENSMUST00000274930.1 ENSMUSG00000126191 (from geneSymbol) uc333boe.1 uc333boe.1 
ENSMUST00000274934.1 ENSMUSG00000126192 ENSMUST00000274934.1 ENSMUSG00000126192 (from geneSymbol) uc333boi.1 uc333boi.1 
ENSMUST00000274935.1 ENSMUSG00000126193 ENSMUST00000274935.1 ENSMUSG00000126193 (from geneSymbol) uc333boj.1 uc333boj.1 
ENSMUST00000274944.1 4930595L18Rik ENSMUST00000274944.1 4930595L18Rik (from geneSymbol) AK019843 uc333bos.1 uc333bos.1 
ENSMUST00000274952.1 ENSMUSG00000126194 ENSMUST00000274952.1 ENSMUSG00000126194 (from geneSymbol) uc333bpa.1 uc333bpa.1 
ENSMUST00000274962.1 ENSMUSG00000126195 ENSMUST00000274962.1 ENSMUSG00000126195 (from geneSymbol) uc333bpk.1 uc333bpk.1 
ENSMUST00000274965.1 Rbakdn ENSMUST00000274965.1 Rbakdn (from geneSymbol) uc333bpn.1 uc333bpn.1 
ENSMUST00000274981.1 ENSMUSG00000126196 ENSMUST00000274981.1 ENSMUSG00000126196 (from geneSymbol) uc333bqd.1 uc333bqd.1 
ENSMUST00000274982.1 ENSMUSG00000126197 ENSMUST00000274982.1 ENSMUSG00000126197 (from geneSymbol) uc333bqe.1 uc333bqe.1 
ENSMUST00000274983.1 ENSMUSG00000126198 ENSMUST00000274983.1 ENSMUSG00000126198 (from geneSymbol) uc333bqf.1 uc333bqf.1 
ENSMUST00000274985.1 ENSMUSG00000126199 ENSMUST00000274985.1 ENSMUSG00000126199 (from geneSymbol) uc333bqh.1 uc333bqh.1 
ENSMUST00000275032.1 ENSMUSG00000126200 ENSMUST00000275032.1 ENSMUSG00000126200 (from geneSymbol) uc333bsb.1 uc333bsb.1 
ENSMUST00000275051.1 ENSMUSG00000126201 ENSMUST00000275051.1 ENSMUSG00000126201 (from geneSymbol) uc333bsu.1 uc333bsu.1 
ENSMUST00000275054.1 ENSMUSG00000126202 ENSMUST00000275054.1 ENSMUSG00000126202 (from geneSymbol) uc333bsx.1 uc333bsx.1 
ENSMUST00000275059.1 ENSMUSG00000126203 ENSMUST00000275059.1 ENSMUSG00000126203 (from geneSymbol) uc333btc.1 uc333btc.1 
ENSMUST00000275060.1 ENSMUSG00000126204 ENSMUST00000275060.1 ENSMUSG00000126204 (from geneSymbol) uc333btd.1 uc333btd.1 
ENSMUST00000275094.1 ENSMUSG00000126205 ENSMUST00000275094.1 ENSMUSG00000126205 (from geneSymbol) uc333bul.1 uc333bul.1 
ENSMUST00000275096.1 ENSMUSG00000126206 ENSMUST00000275096.1 ENSMUSG00000126206 (from geneSymbol) uc333bun.1 uc333bun.1 
ENSMUST00000275100.1 ENSMUSG00000126207 ENSMUST00000275100.1 ENSMUSG00000126207 (from geneSymbol) uc333bur.1 uc333bur.1 
ENSMUST00000275101.1 ENSMUSG00000126208 ENSMUST00000275101.1 ENSMUSG00000126208 (from geneSymbol) uc333bus.1 uc333bus.1 
ENSMUST00000275102.1 ENSMUSG00000126209 ENSMUST00000275102.1 ENSMUSG00000126209 (from geneSymbol) uc333but.1 uc333but.1 
ENSMUST00000275104.1 ENSMUSG00000126210 ENSMUST00000275104.1 ENSMUSG00000126210 (from geneSymbol) uc333buv.1 uc333buv.1 
ENSMUST00000275109.1 ENSMUSG00000126211 ENSMUST00000275109.1 ENSMUSG00000126211 (from geneSymbol) uc333bva.1 uc333bva.1 
ENSMUST00000275116.1 ENSMUSG00000126212 ENSMUST00000275116.1 ENSMUSG00000126212 (from geneSymbol) uc333bvh.1 uc333bvh.1 
ENSMUST00000275117.1 ENSMUSG00000126213 ENSMUST00000275117.1 ENSMUSG00000126213 (from geneSymbol) uc333bvi.1 uc333bvi.1 
ENSMUST00000275119.1 Gm34102 ENSMUST00000275119.1 Gm34102 (from geneSymbol) uc333bvk.1 uc333bvk.1 
ENSMUST00000275122.1 ENSMUSG00000126214 ENSMUST00000275122.1 ENSMUSG00000126214 (from geneSymbol) uc333bvn.1 uc333bvn.1 
ENSMUST00000275138.1 ENSMUSG00000126215 ENSMUST00000275138.1 ENSMUSG00000126215 (from geneSymbol) uc333bwd.1 uc333bwd.1 
ENSMUST00000275145.1 ENSMUSG00000126216 ENSMUST00000275145.1 ENSMUSG00000126216 (from geneSymbol) uc333bwk.1 uc333bwk.1 
ENSMUST00000275146.1 ENSMUSG00000126217 ENSMUST00000275146.1 ENSMUSG00000126217 (from geneSymbol) uc333bwl.1 uc333bwl.1 
ENSMUST00000275147.1 ENSMUSG00000126218 ENSMUST00000275147.1 ENSMUSG00000126218 (from geneSymbol) uc333bwm.1 uc333bwm.1 
ENSMUST00000275156.1 ENSMUSG00000126219 ENSMUST00000275156.1 ENSMUSG00000126219 (from geneSymbol) uc333bwv.1 uc333bwv.1 
ENSMUST00000275170.1 Gm43803 ENSMUST00000275170.1 Gm43803 (from geneSymbol) uc333bxj.1 uc333bxj.1 
ENSMUST00000275172.1 ENSMUSG00000126220 ENSMUST00000275172.1 ENSMUSG00000126220 (from geneSymbol) uc333bxl.1 uc333bxl.1 
ENSMUST00000275174.1 ENSMUSG00000126221 ENSMUST00000275174.1 ENSMUSG00000126221 (from geneSymbol) uc333bxn.1 uc333bxn.1 
ENSMUST00000275175.1 Gm48656 ENSMUST00000275175.1 Gm48656 (from geneSymbol) uc333bxo.1 uc333bxo.1 
ENSMUST00000275178.1 ENSMUSG00000126222 ENSMUST00000275178.1 ENSMUSG00000126222 (from geneSymbol) uc333bxr.1 uc333bxr.1 
ENSMUST00000275179.1 ENSMUSG00000126223 ENSMUST00000275179.1 ENSMUSG00000126223 (from geneSymbol) uc333bxs.1 uc333bxs.1 
ENSMUST00000275180.1 ENSMUSG00000126224 ENSMUST00000275180.1 ENSMUSG00000126224 (from geneSymbol) uc333bxt.1 uc333bxt.1 
ENSMUST00000275181.1 ENSMUSG00000126225 ENSMUST00000275181.1 ENSMUSG00000126225 (from geneSymbol) uc333bxu.1 uc333bxu.1 
ENSMUST00000275183.1 ENSMUSG00000126226 ENSMUST00000275183.1 ENSMUSG00000126226 (from geneSymbol) uc333bxw.1 uc333bxw.1 
ENSMUST00000275191.1 ENSMUSG00000126227 ENSMUST00000275191.1 ENSMUSG00000126227 (from geneSymbol) uc333byd.1 uc333byd.1 
ENSMUST00000275195.1 ENSMUSG00000126228 ENSMUST00000275195.1 ENSMUSG00000126228 (from geneSymbol) uc333byh.1 uc333byh.1 
ENSMUST00000275196.1 ENSMUSG00000126229 ENSMUST00000275196.1 ENSMUSG00000126229 (from geneSymbol) uc333byi.1 uc333byi.1 
ENSMUST00000275198.1 ENSMUSG00000126230 ENSMUST00000275198.1 ENSMUSG00000126230 (from geneSymbol) uc333byk.1 uc333byk.1 
ENSMUST00000275199.1 ENSMUSG00000126231 ENSMUST00000275199.1 ENSMUSG00000126231 (from geneSymbol) uc333byl.1 uc333byl.1 
ENSMUST00000275200.1 ENSMUSG00000126232 ENSMUST00000275200.1 ENSMUSG00000126232 (from geneSymbol) uc333bym.1 uc333bym.1 
ENSMUST00000275204.1 Gm32736 ENSMUST00000275204.1 Gm32736 (from geneSymbol) AK053481 uc333byq.1 uc333byq.1 
ENSMUST00000275246.1 ENSMUSG00000126233 ENSMUST00000275246.1 ENSMUSG00000126233 (from geneSymbol) uc333cac.1 uc333cac.1 
ENSMUST00000275248.1 ENSMUSG00000126234 ENSMUST00000275248.1 ENSMUSG00000126234 (from geneSymbol) uc333cae.1 uc333cae.1 
ENSMUST00000275258.1 ENSMUSG00000126235 ENSMUST00000275258.1 ENSMUSG00000126235 (from geneSymbol) uc333cao.1 uc333cao.1 
ENSMUST00000275263.1 ENSMUSG00000126236 ENSMUST00000275263.1 ENSMUSG00000126236 (from geneSymbol) uc333cat.1 uc333cat.1 
ENSMUST00000275265.1 Gm41668 ENSMUST00000275265.1 Gm41668 (from geneSymbol) uc333cav.1 uc333cav.1 
ENSMUST00000275273.1 ENSMUSG00000126237 ENSMUST00000275273.1 ENSMUSG00000126237 (from geneSymbol) uc333cbd.1 uc333cbd.1 
ENSMUST00000275274.1 ENSMUSG00000126238 ENSMUST00000275274.1 ENSMUSG00000126238 (from geneSymbol) uc333cbe.1 uc333cbe.1 
ENSMUST00000275275.1 ENSMUSG00000126239 ENSMUST00000275275.1 ENSMUSG00000126239 (from geneSymbol) uc333cbf.1 uc333cbf.1 
ENSMUST00000275280.1 ENSMUSG00000126240 ENSMUST00000275280.1 ENSMUSG00000126240 (from geneSymbol) LF199779 uc333cbk.1 uc333cbk.1 
ENSMUST00000275282.1 ENSMUSG00000126242 ENSMUST00000275282.1 ENSMUSG00000126242 (from geneSymbol) uc333cbl.1 uc333cbl.1 
ENSMUST00000275283.1 ENSMUSG00000126243 ENSMUST00000275283.1 ENSMUSG00000126243 (from geneSymbol) uc333cbm.1 uc333cbm.1 
ENSMUST00000275294.1 ENSMUSG00000126244 ENSMUST00000275294.1 ENSMUSG00000126244 (from geneSymbol) uc333cbx.1 uc333cbx.1 
ENSMUST00000275295.1 ENSMUSG00000126245 ENSMUST00000275295.1 ENSMUSG00000126245 (from geneSymbol) uc333cby.1 uc333cby.1 
ENSMUST00000275304.1 ENSMUSG00000126246 ENSMUST00000275304.1 ENSMUSG00000126246 (from geneSymbol) uc333ccb.1 uc333ccb.1 
ENSMUST00000275322.1 ENSMUSG00000126247 ENSMUST00000275322.1 ENSMUSG00000126247 (from geneSymbol) uc333ccd.1 uc333ccd.1 
ENSMUST00000275324.1 Gm35279 ENSMUST00000275324.1 Gm35279 (from geneSymbol) uc333ccf.1 uc333ccf.1 
ENSMUST00000275334.1 ENSMUSG00000126248 ENSMUST00000275334.1 ENSMUSG00000126248 (from geneSymbol) uc333ccp.1 uc333ccp.1 
ENSMUST00000275341.1 1700044K03Rik ENSMUST00000275341.1 1700044K03Rik (from geneSymbol) AK006696 uc333ccw.1 uc333ccw.1 
ENSMUST00000275345.1 ENSMUSG00000126249 ENSMUST00000275345.1 ENSMUSG00000126249 (from geneSymbol) uc333cda.1 uc333cda.1 
ENSMUST00000275356.1 ENSMUSG00000126250 ENSMUST00000275356.1 ENSMUSG00000126250 (from geneSymbol) uc333cdl.1 uc333cdl.1 
ENSMUST00000275357.1 ENSMUSG00000126251 ENSMUST00000275357.1 ENSMUSG00000126251 (from geneSymbol) uc333cdm.1 uc333cdm.1 
ENSMUST00000275358.1 Gm13257 ENSMUST00000275358.1 Gm13257 (from geneSymbol) uc333cdn.1 uc333cdn.1 
ENSMUST00000275359.1 ENSMUSG00000121843 ENSMUST00000275359.1 ENSMUSG00000121843 (from geneSymbol) uc333cdo.1 uc333cdo.1 
ENSMUST00000275361.1 ENSMUSG00000126252 ENSMUST00000275361.1 ENSMUSG00000126252 (from geneSymbol) uc333cdq.1 uc333cdq.1 
ENSMUST00000275363.1 ENSMUSG00000126253 ENSMUST00000275363.1 ENSMUSG00000126253 (from geneSymbol) uc333cds.1 uc333cds.1 
ENSMUST00000275365.1 ENSMUSG00000126254 ENSMUST00000275365.1 ENSMUSG00000126254 (from geneSymbol) uc333cdu.1 uc333cdu.1 
ENSMUST00000275366.1 ENSMUSG00000126255 ENSMUST00000275366.1 ENSMUSG00000126255 (from geneSymbol) uc333cdv.1 uc333cdv.1 
ENSMUST00000275369.1 Gm26832 ENSMUST00000275369.1 Gm26832 (from geneSymbol) AK016044 uc333cdy.1 uc333cdy.1 
ENSMUST00000275373.1 ENSMUSG00000126256 ENSMUST00000275373.1 ENSMUSG00000126256 (from geneSymbol) uc333cec.1 uc333cec.1 
ENSMUST00000275374.1 ENSMUSG00000126257 ENSMUST00000275374.1 ENSMUSG00000126257 (from geneSymbol) uc333ced.1 uc333ced.1 
ENSMUST00000275376.1 ENSMUSG00000126258 ENSMUST00000275376.1 ENSMUSG00000126258 (from geneSymbol) uc333cef.1 uc333cef.1 
ENSMUST00000275377.1 ENSMUSG00000126259 ENSMUST00000275377.1 ENSMUSG00000126259 (from geneSymbol) uc333ceg.1 uc333ceg.1 
ENSMUST00000275386.1 ENSMUSG00000126260 ENSMUST00000275386.1 ENSMUSG00000126260 (from geneSymbol) uc333cep.1 uc333cep.1 
ENSMUST00000275391.1 ENSMUSG00000126261 ENSMUST00000275391.1 ENSMUSG00000126261 (from geneSymbol) uc333ceu.1 uc333ceu.1 
ENSMUST00000275392.1 ENSMUSG00000126262 ENSMUST00000275392.1 ENSMUSG00000126262 (from geneSymbol) uc333cev.1 uc333cev.1 
ENSMUST00000275393.1 ENSMUSG00000126263 ENSMUST00000275393.1 ENSMUSG00000126263 (from geneSymbol) uc333cew.1 uc333cew.1 
ENSMUST00000275394.1 ENSMUSG00000126264 ENSMUST00000275394.1 ENSMUSG00000126264 (from geneSymbol) uc333cex.1 uc333cex.1 
ENSMUST00000275401.1 ENSMUSG00000126265 ENSMUST00000275401.1 ENSMUSG00000126265 (from geneSymbol) uc333cfe.1 uc333cfe.1 
ENSMUST00000275402.1 ENSMUSG00000126266 ENSMUST00000275402.1 ENSMUSG00000126266 (from geneSymbol) uc333cff.1 uc333cff.1 
ENSMUST00000275403.1 ENSMUSG00000126267 ENSMUST00000275403.1 ENSMUSG00000126267 (from geneSymbol) uc333cfg.1 uc333cfg.1 
ENSMUST00000275405.1 ENSMUSG00000126268 ENSMUST00000275405.1 ENSMUSG00000126268 (from geneSymbol) uc333cfi.1 uc333cfi.1 
ENSMUST00000275409.1 ENSMUSG00000126269 ENSMUST00000275409.1 ENSMUSG00000126269 (from geneSymbol) uc333cfm.1 uc333cfm.1 
ENSMUST00000275411.1 ENSMUSG00000126270 ENSMUST00000275411.1 ENSMUSG00000126270 (from geneSymbol) uc333cfo.1 uc333cfo.1 
ENSMUST00000275418.1 ENSMUSG00000126271 ENSMUST00000275418.1 ENSMUSG00000126271 (from geneSymbol) uc333cfv.1 uc333cfv.1 
ENSMUST00000275420.1 ENSMUSG00000126272 ENSMUST00000275420.1 ENSMUSG00000126272 (from geneSymbol) uc333cfx.1 uc333cfx.1 
ENSMUST00000275422.1 ENSMUSG00000126273 ENSMUST00000275422.1 ENSMUSG00000126273 (from geneSymbol) uc333cfz.1 uc333cfz.1 
ENSMUST00000275425.1 A430027H14Rik ENSMUST00000275425.1 A430027H14Rik (from geneSymbol) uc333cgc.1 uc333cgc.1 
ENSMUST00000275426.1 Gm14064 ENSMUST00000275426.1 Gm14064 (from geneSymbol) uc333cgd.1 uc333cgd.1 
ENSMUST00000275455.1 ENSMUSG00000126274 ENSMUST00000275455.1 ENSMUSG00000126274 (from geneSymbol) uc333chg.1 uc333chg.1 
ENSMUST00000275456.1 ENSMUSG00000126275 ENSMUST00000275456.1 ENSMUSG00000126275 (from geneSymbol) uc333chh.1 uc333chh.1 
ENSMUST00000275461.1 ENSMUSG00000126276 ENSMUST00000275461.1 ENSMUSG00000126276 (from geneSymbol) uc333chm.1 uc333chm.1 
ENSMUST00000275470.1 ENSMUSG00000126277 ENSMUST00000275470.1 ENSMUSG00000126277 (from geneSymbol) uc333chv.1 uc333chv.1 
ENSMUST00000275472.1 ENSMUSG00000126278 ENSMUST00000275472.1 ENSMUSG00000126278 (from geneSymbol) uc333chx.1 uc333chx.1 
ENSMUST00000275473.1 ENSMUSG00000126279 ENSMUST00000275473.1 ENSMUSG00000126279 (from geneSymbol) uc333chy.1 uc333chy.1 
ENSMUST00000275475.1 ENSMUSG00000126280 ENSMUST00000275475.1 ENSMUSG00000126280 (from geneSymbol) uc333cia.1 uc333cia.1 
ENSMUST00000275477.1 ENSMUSG00000126281 ENSMUST00000275477.1 ENSMUSG00000126281 (from geneSymbol) uc333cic.1 uc333cic.1 
ENSMUST00000275481.1 ENSMUSG00000126282 ENSMUST00000275481.1 ENSMUSG00000126282 (from geneSymbol) uc333cig.1 uc333cig.1 
ENSMUST00000275482.1 ENSMUSG00000126283 ENSMUST00000275482.1 ENSMUSG00000126283 (from geneSymbol) uc333cih.1 uc333cih.1 
ENSMUST00000275483.1 Gm46069 ENSMUST00000275483.1 Gm46069 (from geneSymbol) uc333cii.1 uc333cii.1 
ENSMUST00000275485.1 ENSMUSG00000126284 ENSMUST00000275485.1 ENSMUSG00000126284 (from geneSymbol) uc333cik.1 uc333cik.1 
ENSMUST00000275489.1 ENSMUSG00000126285 ENSMUST00000275489.1 ENSMUSG00000126285 (from geneSymbol) uc333cio.1 uc333cio.1 
ENSMUST00000275491.1 ENSMUSG00000126286 ENSMUST00000275491.1 ENSMUSG00000126286 (from geneSymbol) uc333ciq.1 uc333ciq.1 
ENSMUST00000275492.1 ENSMUSG00000126287 ENSMUST00000275492.1 ENSMUSG00000126287 (from geneSymbol) uc333cir.1 uc333cir.1 
ENSMUST00000275494.1 ENSMUSG00000126288 ENSMUST00000275494.1 ENSMUSG00000126288 (from geneSymbol) uc333cit.1 uc333cit.1 
ENSMUST00000275495.1 ENSMUSG00000126289 ENSMUST00000275495.1 ENSMUSG00000126289 (from geneSymbol) uc333ciu.1 uc333ciu.1 
ENSMUST00000275496.1 ENSMUSG00000126290 ENSMUST00000275496.1 ENSMUSG00000126290 (from geneSymbol) uc333civ.1 uc333civ.1 
ENSMUST00000275497.1 ENSMUSG00000126291 ENSMUST00000275497.1 ENSMUSG00000126291 (from geneSymbol) FJ654125 uc333ciw.1 uc333ciw.1 
ENSMUST00000275498.1 ENSMUSG00000126292 ENSMUST00000275498.1 ENSMUSG00000126292 (from geneSymbol) uc333cix.1 uc333cix.1 
ENSMUST00000275499.1 ENSMUSG00000126293 ENSMUST00000275499.1 ENSMUSG00000126293 (from geneSymbol) uc333ciy.1 uc333ciy.1 
ENSMUST00000275500.1 ENSMUSG00000126294 ENSMUST00000275500.1 ENSMUSG00000126294 (from geneSymbol) uc333ciz.1 uc333ciz.1 
ENSMUST00000275505.1 ENSMUSG00000126295 ENSMUST00000275505.1 ENSMUSG00000126295 (from geneSymbol) uc333cje.1 uc333cje.1 
ENSMUST00000275506.1 ENSMUSG00000126296 ENSMUST00000275506.1 ENSMUSG00000126296 (from geneSymbol) uc333cjf.1 uc333cjf.1 
ENSMUST00000275507.1 ENSMUSG00000126297 ENSMUST00000275507.1 ENSMUSG00000126297 (from geneSymbol) uc333cjg.1 uc333cjg.1 
ENSMUST00000275520.1 ENSMUSG00000126298 ENSMUST00000275520.1 ENSMUSG00000126298 (from geneSymbol) uc333cjt.1 uc333cjt.1 
ENSMUST00000275523.1 ENSMUSG00000126300 ENSMUST00000275523.1 ENSMUSG00000126300 (from geneSymbol) uc333cju.1 uc333cju.1 
ENSMUST00000275528.1 ENSMUSG00000126301 ENSMUST00000275528.1 ENSMUSG00000126301 (from geneSymbol) uc333cjz.1 uc333cjz.1 
ENSMUST00000275529.1 ENSMUSG00000126302 ENSMUST00000275529.1 ENSMUSG00000126302 (from geneSymbol) uc333cka.1 uc333cka.1 
ENSMUST00000275531.1 ENSMUSG00000126303 ENSMUST00000275531.1 ENSMUSG00000126303 (from geneSymbol) uc333ckc.1 uc333ckc.1 
ENSMUST00000275542.1 ENSMUSG00000126304 ENSMUST00000275542.1 ENSMUSG00000126304 (from geneSymbol) uc333ckn.1 uc333ckn.1 
ENSMUST00000275559.1 ENSMUSG00000126305 ENSMUST00000275559.1 ENSMUSG00000126305 (from geneSymbol) uc333cle.1 uc333cle.1 
ENSMUST00000275563.1 ENSMUSG00000126306 ENSMUST00000275563.1 ENSMUSG00000126306 (from geneSymbol) uc333clh.1 uc333clh.1 
ENSMUST00000275567.1 ENSMUSG00000126307 ENSMUST00000275567.1 ENSMUSG00000126307 (from geneSymbol) uc333cll.1 uc333cll.1 
ENSMUST00000275569.1 Nrg3os ENSMUST00000275569.1 Nrg3os (from geneSymbol) AK015934 uc333cln.1 uc333cln.1 
ENSMUST00000275579.1 ENSMUSG00000126308 ENSMUST00000275579.1 ENSMUSG00000126308 (from geneSymbol) uc333clx.1 uc333clx.1 
ENSMUST00000275580.1 ENSMUSG00000126309 ENSMUST00000275580.1 ENSMUSG00000126309 (from geneSymbol) uc333cly.1 uc333cly.1 
ENSMUST00000275581.1 ENSMUSG00000126310 ENSMUST00000275581.1 ENSMUSG00000126310 (from geneSymbol) uc333clz.1 uc333clz.1 
ENSMUST00000275582.1 ENSMUSG00000126311 ENSMUST00000275582.1 ENSMUSG00000126311 (from geneSymbol) uc333cma.1 uc333cma.1 
ENSMUST00000275583.1 ENSMUSG00000126312 ENSMUST00000275583.1 ENSMUSG00000126312 (from geneSymbol) uc333cmb.1 uc333cmb.1 
ENSMUST00000275584.1 Gm46609 ENSMUST00000275584.1 Gm46609 (from geneSymbol) uc333cmc.1 uc333cmc.1 
ENSMUST00000275618.1 ENSMUSG00000121456 ENSMUST00000275618.1 ENSMUSG00000121456 (from geneSymbol) AK041589 uc333cni.1 uc333cni.1 
ENSMUST00000275625.1 A330043C09Rik ENSMUST00000275625.1 A330043C09Rik (from geneSymbol) AK039441 uc333cnp.1 uc333cnp.1 
ENSMUST00000275634.1 ENSMUSG00000126315 ENSMUST00000275634.1 ENSMUSG00000126315 (from geneSymbol) uc333cny.1 uc333cny.1 
ENSMUST00000275635.1 ENSMUSG00000126316 ENSMUST00000275635.1 ENSMUSG00000126316 (from geneSymbol) uc333cnz.1 uc333cnz.1 
ENSMUST00000275640.1 ENSMUSG00000126317 ENSMUST00000275640.1 ENSMUSG00000126317 (from geneSymbol) uc333coe.1 uc333coe.1 
ENSMUST00000275645.1 Gm44140 ENSMUST00000275645.1 Gm44140 (from geneSymbol) uc333coj.1 uc333coj.1 
ENSMUST00000275666.1 Gm28723 ENSMUST00000275666.1 Gm28723 (from geneSymbol) AK086591 uc333cpe.1 uc333cpe.1 
ENSMUST00000275732.1 ENSMUSG00000126318 ENSMUST00000275732.1 ENSMUSG00000126318 (from geneSymbol) uc333crs.1 uc333crs.1 
ENSMUST00000275735.1 ENSMUSG00000126319 ENSMUST00000275735.1 ENSMUSG00000126319 (from geneSymbol) uc333crv.1 uc333crv.1 
ENSMUST00000275738.1 ENSMUSG00000126320 ENSMUST00000275738.1 ENSMUSG00000126320 (from geneSymbol) uc333cry.1 uc333cry.1 
ENSMUST00000275740.1 ENSMUSG00000126322 ENSMUST00000275740.1 ENSMUSG00000126322 (from geneSymbol) uc333crz.1 uc333crz.1 
ENSMUST00000275744.1 ENSMUSG00000126323 ENSMUST00000275744.1 ENSMUSG00000126323 (from geneSymbol) uc333csd.1 uc333csd.1 
ENSMUST00000275746.1 ENSMUSG00000126324 ENSMUST00000275746.1 ENSMUSG00000126324 (from geneSymbol) uc333csf.1 uc333csf.1 
ENSMUST00000275747.1 ENSMUSG00000126325 ENSMUST00000275747.1 ENSMUSG00000126325 (from geneSymbol) uc333csg.1 uc333csg.1 
ENSMUST00000275748.1 ENSMUSG00000126326 ENSMUST00000275748.1 ENSMUSG00000126326 (from geneSymbol) uc333csh.1 uc333csh.1 
ENSMUST00000275755.1 ENSMUSG00000126327 ENSMUST00000275755.1 ENSMUSG00000126327 (from geneSymbol) uc333cso.1 uc333cso.1 
ENSMUST00000275762.1 Gm48427 ENSMUST00000275762.1 Gm48427 (from geneSymbol) uc333csv.1 uc333csv.1 
ENSMUST00000275772.1 ENSMUSG00000126328 ENSMUST00000275772.1 ENSMUSG00000126328 (from geneSymbol) uc333ctf.1 uc333ctf.1 
ENSMUST00000275774.1 ENSMUSG00000126329 ENSMUST00000275774.1 ENSMUSG00000126329 (from geneSymbol) uc333cth.1 uc333cth.1 
ENSMUST00000275776.1 ENSMUSG00000126330 ENSMUST00000275776.1 ENSMUSG00000126330 (from geneSymbol) uc333ctj.1 uc333ctj.1 
ENSMUST00000275778.1 ENSMUSG00000126331 ENSMUST00000275778.1 ENSMUSG00000126331 (from geneSymbol) uc333ctl.1 uc333ctl.1 
ENSMUST00000275779.1 ENSMUSG00000126332 ENSMUST00000275779.1 ENSMUSG00000126332 (from geneSymbol) AK039933 uc333ctm.1 uc333ctm.1 
ENSMUST00000275781.1 ENSMUSG00000126333 ENSMUST00000275781.1 ENSMUSG00000126333 (from geneSymbol) uc333cto.1 uc333cto.1 
ENSMUST00000275782.1 ENSMUSG00000126334 ENSMUST00000275782.1 ENSMUSG00000126334 (from geneSymbol) uc333ctp.1 uc333ctp.1 
ENSMUST00000275784.1 E030037K01Rik ENSMUST00000275784.1 E030037K01Rik (from geneSymbol) uc333ctr.1 uc333ctr.1 
ENSMUST00000275790.1 ENSMUSG00000126335 ENSMUST00000275790.1 ENSMUSG00000126335 (from geneSymbol) uc333ctx.1 uc333ctx.1 
ENSMUST00000275793.1 ENSMUSG00000126336 ENSMUST00000275793.1 ENSMUSG00000126336 (from geneSymbol) uc333cua.1 uc333cua.1 
ENSMUST00000275797.1 ENSMUSG00000126337 ENSMUST00000275797.1 ENSMUSG00000126337 (from geneSymbol) uc333cue.1 uc333cue.1 
ENSMUST00000275798.1 ENSMUSG00000126338 ENSMUST00000275798.1 ENSMUSG00000126338 (from geneSymbol) uc333cuf.1 uc333cuf.1 
ENSMUST00000275799.1 9130004C02Rik ENSMUST00000275799.1 9130004C02Rik (from geneSymbol) uc333cug.1 uc333cug.1 
ENSMUST00000275802.1 ENSMUSG00000126339 ENSMUST00000275802.1 ENSMUSG00000126339 (from geneSymbol) uc333cuj.1 uc333cuj.1 
ENSMUST00000275805.1 4831440D22Rik ENSMUST00000275805.1 4831440D22Rik (from geneSymbol) uc333cum.1 uc333cum.1 
ENSMUST00000275818.1 Gm36520 ENSMUST00000275818.1 Gm36520 (from geneSymbol) uc333cuz.1 uc333cuz.1 
ENSMUST00000275827.1 ENSMUSG00000126340 ENSMUST00000275827.1 ENSMUSG00000126340 (from geneSymbol) uc333cvi.1 uc333cvi.1 
ENSMUST00000275828.1 ENSMUSG00000126341 ENSMUST00000275828.1 ENSMUSG00000126341 (from geneSymbol) uc333cvj.1 uc333cvj.1 
ENSMUST00000275829.1 ENSMUSG00000126342 ENSMUST00000275829.1 ENSMUSG00000126342 (from geneSymbol) uc333cvk.1 uc333cvk.1 
ENSMUST00000275830.1 ENSMUSG00000126343 ENSMUST00000275830.1 ENSMUSG00000126343 (from geneSymbol) uc333cvl.1 uc333cvl.1 
ENSMUST00000275831.1 ENSMUSG00000126344 ENSMUST00000275831.1 ENSMUSG00000126344 (from geneSymbol) uc333cvm.1 uc333cvm.1 
ENSMUST00000275832.1 ENSMUSG00000126345 ENSMUST00000275832.1 ENSMUSG00000126345 (from geneSymbol) uc333cvn.1 uc333cvn.1 
ENSMUST00000275833.1 Gm43109 ENSMUST00000275833.1 Gm43109 (from geneSymbol) uc333cvo.1 uc333cvo.1 
ENSMUST00000275835.1 ENSMUSG00000126346 ENSMUST00000275835.1 ENSMUSG00000126346 (from geneSymbol) uc333cvq.1 uc333cvq.1 
ENSMUST00000275837.1 ENSMUSG00000126347 ENSMUST00000275837.1 ENSMUSG00000126347 (from geneSymbol) uc333cvs.1 uc333cvs.1 
ENSMUST00000275853.1 ENSMUSG00000126348 ENSMUST00000275853.1 ENSMUSG00000126348 (from geneSymbol) uc333cwi.1 uc333cwi.1 
ENSMUST00000275860.1 Gm12542 ENSMUST00000275860.1 Gm12542 (from geneSymbol) AK153620 uc333cwp.1 uc333cwp.1 
ENSMUST00000275862.1 ENSMUSG00000126349 ENSMUST00000275862.1 ENSMUSG00000126349 (from geneSymbol) uc333cwr.1 uc333cwr.1 
ENSMUST00000275864.1 ENSMUSG00000126350 ENSMUST00000275864.1 ENSMUSG00000126350 (from geneSymbol) AK132630 uc333cwt.1 uc333cwt.1 
ENSMUST00000275873.1 Gm13817 ENSMUST00000275873.1 Gm13817 (from geneSymbol) uc333cxc.1 uc333cxc.1 
ENSMUST00000276005.1 ENSMUSG00000126351 ENSMUST00000276005.1 ENSMUSG00000126351 (from geneSymbol) uc333dce.1 uc333dce.1 
ENSMUST00000276006.1 ENSMUSG00000126352 ENSMUST00000276006.1 ENSMUSG00000126352 (from geneSymbol) AK009271 uc333dcf.1 uc333dcf.1 
ENSMUST00000276009.1 Gm57011 ENSMUST00000276009.1 Gm57011 (from geneSymbol) uc333dci.1 uc333dci.1 
ENSMUST00000276021.1 ENSMUSG00000126353 ENSMUST00000276021.1 ENSMUSG00000126353 (from geneSymbol) uc333dcu.1 uc333dcu.1 
ENSMUST00000276025.1 ENSMUSG00000126354 ENSMUST00000276025.1 ENSMUSG00000126354 (from geneSymbol) uc333dcy.1 uc333dcy.1 
ENSMUST00000276026.1 ENSMUSG00000126355 ENSMUST00000276026.1 ENSMUSG00000126355 (from geneSymbol) uc333dcz.1 uc333dcz.1 
ENSMUST00000276033.1 Gm14249 ENSMUST00000276033.1 Gm14249 (from geneSymbol) AK132797 uc333ddg.1 uc333ddg.1 
ENSMUST00000276043.1 ENSMUSG00000126356 ENSMUST00000276043.1 ENSMUSG00000126356 (from geneSymbol) AK008669 uc333ddq.1 uc333ddq.1 
ENSMUST00000276046.1 ENSMUSG00000126357 ENSMUST00000276046.1 ENSMUSG00000126357 (from geneSymbol) uc333ddt.1 uc333ddt.1 
ENSMUST00000276047.1 ENSMUSG00000126358 ENSMUST00000276047.1 ENSMUSG00000126358 (from geneSymbol) uc333ddu.1 uc333ddu.1 
ENSMUST00000276048.1 ENSMUSG00000126359 ENSMUST00000276048.1 ENSMUSG00000126359 (from geneSymbol) uc333ddv.1 uc333ddv.1 
ENSMUST00000276049.1 ENSMUSG00000126360 ENSMUST00000276049.1 ENSMUSG00000126360 (from geneSymbol) uc333ddw.1 uc333ddw.1 
ENSMUST00000276050.1 ENSMUSG00000126361 ENSMUST00000276050.1 ENSMUSG00000126361 (from geneSymbol) uc333ddx.1 uc333ddx.1 
ENSMUST00000276051.1 ENSMUSG00000126362 ENSMUST00000276051.1 ENSMUSG00000126362 (from geneSymbol) uc333ddy.1 uc333ddy.1 
ENSMUST00000276052.1 ENSMUSG00000126363 ENSMUST00000276052.1 ENSMUSG00000126363 (from geneSymbol) uc333ddz.1 uc333ddz.1 
ENSMUST00000276053.1 ENSMUSG00000126364 ENSMUST00000276053.1 ENSMUSG00000126364 (from geneSymbol) uc333dea.1 uc333dea.1 
ENSMUST00000276055.1 4932435O22Rik ENSMUST00000276055.1 4932435O22Rik (from geneSymbol) AK053334 uc333dec.1 uc333dec.1 
ENSMUST00000276077.1 ENSMUSG00000126365 ENSMUST00000276077.1 ENSMUSG00000126365 (from geneSymbol) uc333dey.1 uc333dey.1 
ENSMUST00000276079.1 ENSMUSG00000126366 ENSMUST00000276079.1 ENSMUSG00000126366 (from geneSymbol) uc333dfa.1 uc333dfa.1 
ENSMUST00000276089.1 ENSMUSG00000126367 ENSMUST00000276089.1 ENSMUSG00000126367 (from geneSymbol) uc333dfk.1 uc333dfk.1 
ENSMUST00000276090.1 ENSMUSG00000126368 ENSMUST00000276090.1 ENSMUSG00000126368 (from geneSymbol) uc333dfl.1 uc333dfl.1 
ENSMUST00000276091.1 ENSMUSG00000126369 ENSMUST00000276091.1 ENSMUSG00000126369 (from geneSymbol) uc333dfm.1 uc333dfm.1 
ENSMUST00000276097.1 ENSMUSG00000126370 ENSMUST00000276097.1 ENSMUSG00000126370 (from geneSymbol) uc333dfs.1 uc333dfs.1 
ENSMUST00000276098.1 ENSMUSG00000126371 ENSMUST00000276098.1 ENSMUSG00000126371 (from geneSymbol) uc333dft.1 uc333dft.1 
ENSMUST00000276102.1 ENSMUSG00000126372 ENSMUST00000276102.1 ENSMUSG00000126372 (from geneSymbol) uc333dfx.1 uc333dfx.1 
ENSMUST00000276103.1 ENSMUSG00000126373 ENSMUST00000276103.1 ENSMUSG00000126373 (from geneSymbol) uc333dfy.1 uc333dfy.1 
ENSMUST00000276104.1 ENSMUSG00000126374 ENSMUST00000276104.1 ENSMUSG00000126374 (from geneSymbol) uc333dfz.1 uc333dfz.1 
ENSMUST00000276107.1 ENSMUSG00000126375 ENSMUST00000276107.1 ENSMUSG00000126375 (from geneSymbol) uc333dgc.1 uc333dgc.1 
ENSMUST00000276117.1 ENSMUSG00000126376 ENSMUST00000276117.1 ENSMUSG00000126376 (from geneSymbol) uc333dgm.1 uc333dgm.1 
ENSMUST00000276121.1 ENSMUSG00000126377 ENSMUST00000276121.1 ENSMUSG00000126377 (from geneSymbol) uc333dgq.1 uc333dgq.1 
ENSMUST00000276122.1 ENSMUSG00000126378 ENSMUST00000276122.1 ENSMUSG00000126378 (from geneSymbol) uc333dgr.1 uc333dgr.1 
ENSMUST00000276125.1 ENSMUSG00000126379 ENSMUST00000276125.1 ENSMUSG00000126379 (from geneSymbol) AK016087 uc333dgu.1 uc333dgu.1 
ENSMUST00000276127.1 ENSMUSG00000126380 ENSMUST00000276127.1 ENSMUSG00000126380 (from geneSymbol) uc333dgw.1 uc333dgw.1 
ENSMUST00000276129.1 ENSMUSG00000126381 ENSMUST00000276129.1 ENSMUSG00000126381 (from geneSymbol) uc333dgy.1 uc333dgy.1 
ENSMUST00000276130.1 ENSMUSG00000126382 ENSMUST00000276130.1 ENSMUSG00000126382 (from geneSymbol) uc333dgz.1 uc333dgz.1 
ENSMUST00000276134.1 ENSMUSG00000126383 ENSMUST00000276134.1 ENSMUSG00000126383 (from geneSymbol) uc333dhd.1 uc333dhd.1 
ENSMUST00000276135.1 ENSMUSG00000126384 ENSMUST00000276135.1 ENSMUSG00000126384 (from geneSymbol) uc333dhe.1 uc333dhe.1 
ENSMUST00000276138.1 Gm32304 ENSMUST00000276138.1 Gm32304 (from geneSymbol) KY468048 uc333dhg.1 uc333dhg.1 
ENSMUST00000276140.1 ENSMUSG00000126385 ENSMUST00000276140.1 ENSMUSG00000126385 (from geneSymbol) uc333dhi.1 uc333dhi.1 
ENSMUST00000276145.1 ENSMUSG00000126387 ENSMUST00000276145.1 ENSMUSG00000126387 (from geneSymbol) uc333dhl.1 uc333dhl.1 
ENSMUST00000276146.1 ENSMUSG00000126388 ENSMUST00000276146.1 ENSMUSG00000126388 (from geneSymbol) uc333dhm.1 uc333dhm.1 
ENSMUST00000276147.1 ENSMUSG00000126389 ENSMUST00000276147.1 ENSMUSG00000126389 (from geneSymbol) uc333dhn.1 uc333dhn.1 
ENSMUST00000276148.1 ENSMUSG00000126390 ENSMUST00000276148.1 ENSMUSG00000126390 (from geneSymbol) uc333dho.1 uc333dho.1 
ENSMUST00000276156.1 ENSMUSG00000126391 ENSMUST00000276156.1 ENSMUSG00000126391 (from geneSymbol) uc333dhw.1 uc333dhw.1 
ENSMUST00000276158.1 ENSMUSG00000126392 ENSMUST00000276158.1 ENSMUSG00000126392 (from geneSymbol) uc333dhy.1 uc333dhy.1 
ENSMUST00000276159.1 ENSMUSG00000126393 ENSMUST00000276159.1 ENSMUSG00000126393 (from geneSymbol) uc333dhz.1 uc333dhz.1 
ENSMUST00000276160.1 ENSMUSG00000126394 ENSMUST00000276160.1 ENSMUSG00000126394 (from geneSymbol) uc333dia.1 uc333dia.1 
ENSMUST00000276165.1 ENSMUSG00000126395 ENSMUST00000276165.1 ENSMUSG00000126395 (from geneSymbol) uc333dif.1 uc333dif.1 
ENSMUST00000276166.1 ENSMUSG00000126396 ENSMUST00000276166.1 ENSMUSG00000126396 (from geneSymbol) uc333dig.1 uc333dig.1 
ENSMUST00000276167.1 ENSMUSG00000126397 ENSMUST00000276167.1 ENSMUSG00000126397 (from geneSymbol) uc333dih.1 uc333dih.1 
ENSMUST00000276175.1 ENSMUSG00000126398 ENSMUST00000276175.1 ENSMUSG00000126398 (from geneSymbol) uc333dip.1 uc333dip.1 
ENSMUST00000276176.1 0610009L18Rik ENSMUST00000276176.1 0610009L18Rik (from geneSymbol) AK005967 uc333diq.1 uc333diq.1 
ENSMUST00000276185.1 ENSMUSG00000126399 ENSMUST00000276185.1 ENSMUSG00000126399 (from geneSymbol) uc333diz.1 uc333diz.1 
ENSMUST00000276186.1 ENSMUSG00000126400 ENSMUST00000276186.1 ENSMUSG00000126400 (from geneSymbol) uc333dja.1 uc333dja.1 
ENSMUST00000276206.1 ENSMUSG00000126401 ENSMUST00000276206.1 ENSMUSG00000126401 (from geneSymbol) uc333dju.1 uc333dju.1 
ENSMUST00000276208.1 ENSMUSG00000126402 ENSMUST00000276208.1 ENSMUSG00000126402 (from geneSymbol) uc333djw.1 uc333djw.1 
ENSMUST00000276209.1 ENSMUSG00000126403 ENSMUST00000276209.1 ENSMUSG00000126403 (from geneSymbol) uc333djx.1 uc333djx.1 
ENSMUST00000276210.1 ENSMUSG00000126404 ENSMUST00000276210.1 ENSMUSG00000126404 (from geneSymbol) uc333djy.1 uc333djy.1 
ENSMUST00000276211.1 ENSMUSG00000126405 ENSMUST00000276211.1 ENSMUSG00000126405 (from geneSymbol) uc333djz.1 uc333djz.1 
ENSMUST00000276215.1 ENSMUSG00000126406 ENSMUST00000276215.1 ENSMUSG00000126406 (from geneSymbol) uc333dkd.1 uc333dkd.1 
ENSMUST00000276217.1 ENSMUSG00000126407 ENSMUST00000276217.1 ENSMUSG00000126407 (from geneSymbol) uc333dkf.1 uc333dkf.1 
ENSMUST00000276219.1 ENSMUSG00000126408 ENSMUST00000276219.1 ENSMUSG00000126408 (from geneSymbol) uc333dkh.1 uc333dkh.1 
ENSMUST00000276227.1 ENSMUSG00000126409 ENSMUST00000276227.1 ENSMUSG00000126409 (from geneSymbol) uc333dkp.1 uc333dkp.1 
ENSMUST00000276234.1 Gm8075 ENSMUST00000276234.1 Gm8075 (from geneSymbol) uc333dkv.1 uc333dkv.1 
ENSMUST00000276243.1 ENSMUSG00000126410 ENSMUST00000276243.1 ENSMUSG00000126410 (from geneSymbol) uc333dle.1 uc333dle.1 
ENSMUST00000276255.1 ENSMUSG00000126411 ENSMUST00000276255.1 ENSMUSG00000126411 (from geneSymbol) uc333dlq.1 uc333dlq.1 
ENSMUST00000276256.1 ENSMUSG00000126412 ENSMUST00000276256.1 ENSMUSG00000126412 (from geneSymbol) uc333dlr.1 uc333dlr.1 
ENSMUST00000276258.1 ENSMUSG00000126413 ENSMUST00000276258.1 ENSMUSG00000126413 (from geneSymbol) uc333dlt.1 uc333dlt.1 
ENSMUST00000276259.1 ENSMUSG00000126414 ENSMUST00000276259.1 ENSMUSG00000126414 (from geneSymbol) uc333dlu.1 uc333dlu.1 
ENSMUST00000276265.1 ENSMUSG00000126415 ENSMUST00000276265.1 ENSMUSG00000126415 (from geneSymbol) uc333dma.1 uc333dma.1 
ENSMUST00000276266.1 ENSMUSG00000126416 ENSMUST00000276266.1 ENSMUSG00000126416 (from geneSymbol) uc333dmb.1 uc333dmb.1 
ENSMUST00000276268.1 ENSMUSG00000126417 ENSMUST00000276268.1 ENSMUSG00000126417 (from geneSymbol) uc333dmd.1 uc333dmd.1 
ENSMUST00000276270.1 A730020E08Rik ENSMUST00000276270.1 A730020E08Rik (from geneSymbol) AK158619 uc333dmf.1 uc333dmf.1 
ENSMUST00000276277.1 Gm47847 ENSMUST00000276277.1 Gm47847 (from geneSymbol) AK135698 uc333dmm.1 uc333dmm.1 
ENSMUST00000276281.1 ENSMUSG00000126418 ENSMUST00000276281.1 ENSMUSG00000126418 (from geneSymbol) uc333dmq.1 uc333dmq.1 
ENSMUST00000276282.1 ENSMUSG00000126419 ENSMUST00000276282.1 ENSMUSG00000126419 (from geneSymbol) uc333dmr.1 uc333dmr.1 
ENSMUST00000276283.1 ENSMUSG00000126420 ENSMUST00000276283.1 ENSMUSG00000126420 (from geneSymbol) uc333dms.1 uc333dms.1 
ENSMUST00000276284.1 ENSMUSG00000126421 ENSMUST00000276284.1 ENSMUSG00000126421 (from geneSymbol) uc333dmt.1 uc333dmt.1 
ENSMUST00000276286.1 ENSMUSG00000126422 ENSMUST00000276286.1 ENSMUSG00000126422 (from geneSymbol) uc333dmv.1 uc333dmv.1 
ENSMUST00000276287.1 Gm57355 ENSMUST00000276287.1 Gm57355 (from geneSymbol) uc333dmw.1 uc333dmw.1 
ENSMUST00000276295.1 Gm28806 ENSMUST00000276295.1 Gm28806 (from geneSymbol) uc333dne.1 uc333dne.1 
ENSMUST00000276299.1 ENSMUSG00000126424 ENSMUST00000276299.1 ENSMUSG00000126424 (from geneSymbol) uc333dni.1 uc333dni.1 
ENSMUST00000276301.1 ENSMUSG00000126425 ENSMUST00000276301.1 ENSMUSG00000126425 (from geneSymbol) uc333dnj.1 uc333dnj.1 
ENSMUST00000276304.1 ENSMUSG00000126426 ENSMUST00000276304.1 ENSMUSG00000126426 (from geneSymbol) uc333dnm.1 uc333dnm.1 
ENSMUST00000276306.1 ENSMUSG00000126427 ENSMUST00000276306.1 ENSMUSG00000126427 (from geneSymbol) uc333dno.1 uc333dno.1 
ENSMUST00000276309.1 ENSMUSG00000126428 ENSMUST00000276309.1 ENSMUSG00000126428 (from geneSymbol) uc333dnr.1 uc333dnr.1 
ENSMUST00000276310.1 ENSMUSG00000126429 ENSMUST00000276310.1 ENSMUSG00000126429 (from geneSymbol) uc333dns.1 uc333dns.1 
ENSMUST00000276311.1 ENSMUSG00000126430 ENSMUST00000276311.1 ENSMUSG00000126430 (from geneSymbol) uc333dnt.1 uc333dnt.1 
ENSMUST00000276327.1 ENSMUSG00000126431 ENSMUST00000276327.1 ENSMUSG00000126431 (from geneSymbol) uc333doj.1 uc333doj.1 
ENSMUST00000276330.1 ENSMUSG00000126432 ENSMUST00000276330.1 ENSMUSG00000126432 (from geneSymbol) uc333dom.1 uc333dom.1 
ENSMUST00000276331.1 ENSMUSG00000126433 ENSMUST00000276331.1 ENSMUSG00000126433 (from geneSymbol) uc333don.1 uc333don.1 
ENSMUST00000276332.1 ENSMUSG00000126434 ENSMUST00000276332.1 ENSMUSG00000126434 (from geneSymbol) uc333doo.1 uc333doo.1 
ENSMUST00000276337.1 ENSMUSG00000126435 ENSMUST00000276337.1 ENSMUSG00000126435 (from geneSymbol) uc333dos.1 uc333dos.1 
ENSMUST00000276341.1 ENSMUSG00000126436 ENSMUST00000276341.1 ENSMUSG00000126436 (from geneSymbol) uc333dow.1 uc333dow.1 
ENSMUST00000276342.1 ENSMUSG00000126437 ENSMUST00000276342.1 ENSMUSG00000126437 (from geneSymbol) uc333dox.1 uc333dox.1 
ENSMUST00000276343.1 ENSMUSG00000126438 ENSMUST00000276343.1 ENSMUSG00000126438 (from geneSymbol) uc333doy.1 uc333doy.1 
ENSMUST00000276345.1 ENSMUSG00000126439 ENSMUST00000276345.1 ENSMUSG00000126439 (from geneSymbol) uc333dpa.1 uc333dpa.1 
ENSMUST00000276381.1 ENSMUSG00000126440 ENSMUST00000276381.1 ENSMUSG00000126440 (from geneSymbol) uc333dqi.1 uc333dqi.1 
ENSMUST00000276391.1 ENSMUSG00000126441 ENSMUST00000276391.1 ENSMUSG00000126441 (from geneSymbol) uc333dqs.1 uc333dqs.1 
ENSMUST00000276395.1 ENSMUSG00000126442 ENSMUST00000276395.1 ENSMUSG00000126442 (from geneSymbol) uc333dqw.1 uc333dqw.1 
ENSMUST00000276406.1 ENSMUSG00000126443 ENSMUST00000276406.1 ENSMUSG00000126443 (from geneSymbol) uc333drh.1 uc333drh.1 
ENSMUST00000276408.1 ENSMUSG00000126444 ENSMUST00000276408.1 ENSMUSG00000126444 (from geneSymbol) uc333drj.1 uc333drj.1 
ENSMUST00000276411.1 ENSMUSG00000126445 ENSMUST00000276411.1 ENSMUSG00000126445 (from geneSymbol) uc333drm.1 uc333drm.1 
ENSMUST00000276418.1 ENSMUSG00000126446 ENSMUST00000276418.1 ENSMUSG00000126446 (from geneSymbol) uc333drt.1 uc333drt.1 
ENSMUST00000276420.1 ENSMUSG00000126447 ENSMUST00000276420.1 ENSMUSG00000126447 (from geneSymbol) uc333drv.1 uc333drv.1 
ENSMUST00000276422.1 ENSMUSG00000126448 ENSMUST00000276422.1 ENSMUSG00000126448 (from geneSymbol) uc333drw.1 uc333drw.1 
ENSMUST00000276424.1 Gm34189 ENSMUST00000276424.1 Gm34189 (from geneSymbol) uc333dry.1 uc333dry.1 
ENSMUST00000276436.1 ENSMUSG00000126449 ENSMUST00000276436.1 ENSMUSG00000126449 (from geneSymbol) uc333dsk.1 uc333dsk.1 
ENSMUST00000276439.1 ENSMUSG00000126450 ENSMUST00000276439.1 ENSMUSG00000126450 (from geneSymbol) uc333dsn.1 uc333dsn.1 
ENSMUST00000276442.1 ENSMUSG00000126451 ENSMUST00000276442.1 ENSMUSG00000126451 (from geneSymbol) uc333dsq.1 uc333dsq.1 
ENSMUST00000276443.1 Lrrc55os ENSMUST00000276443.1 Lrrc55os (from geneSymbol) BC027685 uc333dsr.1 uc333dsr.1 
ENSMUST00000276467.1 ENSMUSG00000126452 ENSMUST00000276467.1 ENSMUSG00000126452 (from geneSymbol) uc333dto.1 uc333dto.1 
ENSMUST00000276468.1 ENSMUSG00000126453 ENSMUST00000276468.1 ENSMUSG00000126453 (from geneSymbol) uc333dtp.1 uc333dtp.1 
ENSMUST00000276473.1 ENSMUSG00000126454 ENSMUST00000276473.1 ENSMUSG00000126454 (from geneSymbol) uc333dtu.1 uc333dtu.1 
ENSMUST00000276481.1 ENSMUSG00000126455 ENSMUST00000276481.1 ENSMUSG00000126455 (from geneSymbol) uc333duc.1 uc333duc.1 
ENSMUST00000276482.1 ENSMUSG00000126456 ENSMUST00000276482.1 ENSMUSG00000126456 (from geneSymbol) uc333dud.1 uc333dud.1 
ENSMUST00000276484.1 ENSMUSG00000126457 ENSMUST00000276484.1 ENSMUSG00000126457 (from geneSymbol) uc333duf.1 uc333duf.1 
ENSMUST00000276488.1 ENSMUSG00000126458 ENSMUST00000276488.1 ENSMUSG00000126458 (from geneSymbol) uc333duj.1 uc333duj.1 
ENSMUST00000276498.1 ENSMUSG00000126459 ENSMUST00000276498.1 ENSMUSG00000126459 (from geneSymbol) uc333dut.1 uc333dut.1 
ENSMUST00000276505.1 1700041I07Rik ENSMUST00000276505.1 1700041I07Rik (from geneSymbol) AK006673 uc333dva.1 uc333dva.1 
ENSMUST00000276516.1 ENSMUSG00000126460 ENSMUST00000276516.1 ENSMUSG00000126460 (from geneSymbol) uc333dvl.1 uc333dvl.1 
ENSMUST00000276518.1 1700020D12Rik ENSMUST00000276518.1 1700020D12Rik (from geneSymbol) AK006151 uc333dvn.1 uc333dvn.1 
ENSMUST00000276534.1 ENSMUSG00000126461 ENSMUST00000276534.1 ENSMUSG00000126461 (from geneSymbol) uc333dwd.1 uc333dwd.1 
ENSMUST00000276536.1 ENSMUSG00000126462 ENSMUST00000276536.1 ENSMUSG00000126462 (from geneSymbol) uc333dwf.1 uc333dwf.1 
ENSMUST00000276538.1 ENSMUSG00000126463 ENSMUST00000276538.1 ENSMUSG00000126463 (from geneSymbol) uc333dwh.1 uc333dwh.1 
ENSMUST00000276539.1 ENSMUSG00000126464 ENSMUST00000276539.1 ENSMUSG00000126464 (from geneSymbol) uc333dwi.1 uc333dwi.1 
ENSMUST00000276541.1 ENSMUSG00000126465 ENSMUST00000276541.1 ENSMUSG00000126465 (from geneSymbol) uc333dwk.1 uc333dwk.1 
ENSMUST00000276542.1 ENSMUSG00000126466 ENSMUST00000276542.1 ENSMUSG00000126466 (from geneSymbol) uc333dwl.1 uc333dwl.1 
ENSMUST00000276547.1 Gm57359 ENSMUST00000276547.1 Gm57359 (from geneSymbol) uc333dwq.1 uc333dwq.1 
ENSMUST00000276555.1 ENSMUSG00000126468 ENSMUST00000276555.1 ENSMUSG00000126468 (from geneSymbol) uc333dww.1 uc333dww.1 
ENSMUST00000276558.1 Gm11696 ENSMUST00000276558.1 Gm11696 (from geneSymbol) AK028065 uc333dwz.1 uc333dwz.1 
ENSMUST00000276577.1 Gm56902 ENSMUST00000276577.1 Gm56902 (from geneSymbol) uc333dxs.1 uc333dxs.1 
ENSMUST00000276578.1 ENSMUSG00000126469 ENSMUST00000276578.1 ENSMUSG00000126469 (from geneSymbol) LF201846 uc333dxt.1 uc333dxt.1 
ENSMUST00000276579.1 ENSMUSG00000126470 ENSMUST00000276579.1 ENSMUSG00000126470 (from geneSymbol) uc333dxu.1 uc333dxu.1 
ENSMUST00000276580.1 ENSMUSG00000126471 ENSMUST00000276580.1 ENSMUSG00000126471 (from geneSymbol) uc333dxv.1 uc333dxv.1 
ENSMUST00000276586.1 ENSMUSG00000126472 ENSMUST00000276586.1 ENSMUSG00000126472 (from geneSymbol) uc333dyb.1 uc333dyb.1 
ENSMUST00000276587.1 ENSMUSG00000126473 ENSMUST00000276587.1 ENSMUSG00000126473 (from geneSymbol) uc333dyc.1 uc333dyc.1 
ENSMUST00000276588.1 Gm57128 ENSMUST00000276588.1 Gm57128 (from geneSymbol) uc333dyd.1 uc333dyd.1 
ENSMUST00000276593.1 ENSMUSG00000126474 ENSMUST00000276593.1 ENSMUSG00000126474 (from geneSymbol) uc333dyi.1 uc333dyi.1 
ENSMUST00000276596.1 ENSMUSG00000126475 ENSMUST00000276596.1 ENSMUSG00000126475 (from geneSymbol) uc333dyl.1 uc333dyl.1 
ENSMUST00000276599.1 ENSMUSG00000126476 ENSMUST00000276599.1 ENSMUSG00000126476 (from geneSymbol) uc333dyo.1 uc333dyo.1 
ENSMUST00000276600.1 ENSMUSG00000126477 ENSMUST00000276600.1 predicted gene, 36897 (from RefSeq NR_168025.1) NR_168025 uc333dyp.1 uc333dyp.1 
ENSMUST00000276606.1 ENSMUSG00000126478 ENSMUST00000276606.1 ENSMUSG00000126478 (from geneSymbol) uc333dyv.1 uc333dyv.1 
ENSMUST00000276609.1 ENSMUSG00000126479 ENSMUST00000276609.1 ENSMUSG00000126479 (from geneSymbol) uc333dyy.1 uc333dyy.1 
ENSMUST00000276611.1 ENSMUSG00000126480 ENSMUST00000276611.1 ENSMUSG00000126480 (from geneSymbol) uc333dza.1 uc333dza.1 
ENSMUST00000276615.1 ENSMUSG00000126481 ENSMUST00000276615.1 ENSMUSG00000126481 (from geneSymbol) uc333dze.1 uc333dze.1 
ENSMUST00000276617.1 ENSMUSG00000126482 ENSMUST00000276617.1 ENSMUSG00000126482 (from geneSymbol) uc333dzg.1 uc333dzg.1 
ENSMUST00000276630.1 ENSMUSG00000126483 ENSMUST00000276630.1 ENSMUSG00000126483 (from geneSymbol) uc333dzt.1 uc333dzt.1 
ENSMUST00000276631.1 Gm56972 ENSMUST00000276631.1 Gm56972 (from geneSymbol) uc333dzu.1 uc333dzu.1 
ENSMUST00000276632.1 ENSMUSG00000126484 ENSMUST00000276632.1 ENSMUSG00000126484 (from geneSymbol) uc333dzv.1 uc333dzv.1 
ENSMUST00000276633.1 ENSMUSG00000126485 ENSMUST00000276633.1 ENSMUSG00000126485 (from geneSymbol) uc333dzw.1 uc333dzw.1 
ENSMUST00000276634.1 ENSMUSG00000126486 ENSMUST00000276634.1 ENSMUSG00000126486 (from geneSymbol) uc333dzx.1 uc333dzx.1 
ENSMUST00000276636.1 ENSMUSG00000126487 ENSMUST00000276636.1 ENSMUSG00000126487 (from geneSymbol) uc333dzz.1 uc333dzz.1 
ENSMUST00000276637.1 E030044B06Rik ENSMUST00000276637.1 E030044B06Rik (from geneSymbol) AK086879 uc333eaa.1 uc333eaa.1 
ENSMUST00000276666.1 4930471L23Rik ENSMUST00000276666.1 4930471L23Rik (from geneSymbol) AK015553 uc333ebd.1 uc333ebd.1 
ENSMUST00000276684.1 ENSMUSG00000126488 ENSMUST00000276684.1 ENSMUSG00000126488 (from geneSymbol) uc333ebv.1 uc333ebv.1 
ENSMUST00000276690.1 ENSMUSG00000126489 ENSMUST00000276690.1 ENSMUSG00000126489 (from geneSymbol) uc333ecb.1 uc333ecb.1 
ENSMUST00000276691.1 ENSMUSG00000126490 ENSMUST00000276691.1 ENSMUSG00000126490 (from geneSymbol) uc333ecc.1 uc333ecc.1 
ENSMUST00000276692.1 ENSMUSG00000126491 ENSMUST00000276692.1 ENSMUSG00000126491 (from geneSymbol) uc333ecd.1 uc333ecd.1 
ENSMUST00000276693.1 ENSMUSG00000126492 ENSMUST00000276693.1 ENSMUSG00000126492 (from geneSymbol) uc333ece.1 uc333ece.1 
ENSMUST00000276695.1 ENSMUSG00000126493 ENSMUST00000276695.1 ENSMUSG00000126493 (from geneSymbol) uc333ecg.1 uc333ecg.1 
ENSMUST00000276696.1 ENSMUSG00000126494 ENSMUST00000276696.1 ENSMUSG00000126494 (from geneSymbol) uc333ech.1 uc333ech.1 
ENSMUST00000276702.1 ENSMUSG00000126495 ENSMUST00000276702.1 ENSMUSG00000126495 (from geneSymbol) uc333ecn.1 uc333ecn.1 
ENSMUST00000276707.1 ENSMUSG00000126496 ENSMUST00000276707.1 ENSMUSG00000126496 (from geneSymbol) uc333ecs.1 uc333ecs.1 
ENSMUST00000276711.1 ENSMUSG00000126497 ENSMUST00000276711.1 ENSMUSG00000126497 (from geneSymbol) uc333ecv.1 uc333ecv.1 
ENSMUST00000276712.1 ENSMUSG00000126498 ENSMUST00000276712.1 ENSMUSG00000126498 (from geneSymbol) uc333ecw.1 uc333ecw.1 
ENSMUST00000276714.1 Gm16630 ENSMUST00000276714.1 Gm16630 (from geneSymbol) AK158926 uc333ecy.1 uc333ecy.1 
ENSMUST00000276718.1 ENSMUSG00000126499 ENSMUST00000276718.1 ENSMUSG00000126499 (from geneSymbol) uc333edc.1 uc333edc.1 
ENSMUST00000276727.1 ENSMUSG00000126500 ENSMUST00000276727.1 ENSMUSG00000126500 (from geneSymbol) uc333edl.1 uc333edl.1 
ENSMUST00000276729.1 ENSMUSG00000126501 ENSMUST00000276729.1 ENSMUSG00000126501 (from geneSymbol) uc333edn.1 uc333edn.1 
ENSMUST00000276731.1 ENSMUSG00000126502 ENSMUST00000276731.1 ENSMUSG00000126502 (from geneSymbol) uc333edp.1 uc333edp.1 
ENSMUST00000276732.1 Gm37748 ENSMUST00000276732.1 Gm37748 (from geneSymbol) uc333edq.1 uc333edq.1 
ENSMUST00000276733.1 Gm30875 ENSMUST00000276733.1 Gm30875 (from geneSymbol) uc333edr.1 uc333edr.1 
ENSMUST00000276743.1 ENSMUSG00000126503 ENSMUST00000276743.1 ENSMUSG00000126503 (from geneSymbol) uc333eeb.1 uc333eeb.1 
ENSMUST00000276744.1 ENSMUSG00000126504 ENSMUST00000276744.1 ENSMUSG00000126504 (from geneSymbol) uc333eec.1 uc333eec.1 
ENSMUST00000276745.1 ENSMUSG00000126505 ENSMUST00000276745.1 ENSMUSG00000126505 (from geneSymbol) uc333eed.1 uc333eed.1 
ENSMUST00000276747.1 ENSMUSG00000126506 ENSMUST00000276747.1 ENSMUSG00000126506 (from geneSymbol) uc333eef.1 uc333eef.1 
ENSMUST00000276748.1 ENSMUSG00000126507 ENSMUST00000276748.1 ENSMUSG00000126507 (from geneSymbol) uc333eeg.1 uc333eeg.1 
ENSMUST00000276749.1 ENSMUSG00000126508 ENSMUST00000276749.1 ENSMUSG00000126508 (from geneSymbol) uc333eeh.1 uc333eeh.1 
ENSMUST00000276750.1 1700096J18Rik ENSMUST00000276750.1 1700096J18Rik (from geneSymbol) AK007092 uc333eei.1 uc333eei.1 
ENSMUST00000276754.1 ENSMUSG00000126509 ENSMUST00000276754.1 ENSMUSG00000126509 (from geneSymbol) uc333eem.1 uc333eem.1 
ENSMUST00000276770.1 ENSMUSG00000126510 ENSMUST00000276770.1 ENSMUSG00000126510 (from geneSymbol) uc333efc.1 uc333efc.1 
ENSMUST00000276771.1 ENSMUSG00000126511 ENSMUST00000276771.1 ENSMUSG00000126511 (from geneSymbol) uc333efd.1 uc333efd.1 
ENSMUST00000276772.1 ENSMUSG00000126512 ENSMUST00000276772.1 ENSMUSG00000126512 (from geneSymbol) uc333efe.1 uc333efe.1 
ENSMUST00000276775.1 ENSMUSG00000126513 ENSMUST00000276775.1 ENSMUSG00000126513 (from geneSymbol) uc333efh.1 uc333efh.1 
ENSMUST00000276778.1 ENSMUSG00000126514 ENSMUST00000276778.1 ENSMUSG00000126514 (from geneSymbol) uc333efk.1 uc333efk.1 
ENSMUST00000276781.1 ENSMUSG00000126515 ENSMUST00000276781.1 ENSMUSG00000126515 (from geneSymbol) uc333efn.1 uc333efn.1 
ENSMUST00000276786.1 ENSMUSG00000126516 ENSMUST00000276786.1 ENSMUSG00000126516 (from geneSymbol) uc333efs.1 uc333efs.1 
ENSMUST00000276788.1 ENSMUSG00000126517 ENSMUST00000276788.1 ENSMUSG00000126517 (from geneSymbol) uc333efu.1 uc333efu.1 
ENSMUST00000276789.1 ENSMUSG00000126518 ENSMUST00000276789.1 ENSMUSG00000126518 (from geneSymbol) uc333efv.1 uc333efv.1 
ENSMUST00000276804.1 ENSMUSG00000126519 ENSMUST00000276804.1 ENSMUSG00000126519 (from geneSymbol) uc333egk.1 uc333egk.1 
ENSMUST00000276829.1 Gm45079 ENSMUST00000276829.1 Gm45079 (from geneSymbol) uc333ehj.1 uc333ehj.1 
ENSMUST00000276831.1 ENSMUSG00000126520 ENSMUST00000276831.1 ENSMUSG00000126520 (from geneSymbol) uc333ehl.1 uc333ehl.1 
ENSMUST00000276832.1 ENSMUSG00000126521 ENSMUST00000276832.1 ENSMUSG00000126521 (from geneSymbol) uc333ehm.1 uc333ehm.1 
ENSMUST00000276833.1 ENSMUSG00000126522 ENSMUST00000276833.1 ENSMUSG00000126522 (from geneSymbol) uc333ehn.1 uc333ehn.1 
ENSMUST00000276836.1 ENSMUSG00000126523 ENSMUST00000276836.1 ENSMUSG00000126523 (from geneSymbol) uc333ehq.1 uc333ehq.1 
ENSMUST00000276837.1 ENSMUSG00000126524 ENSMUST00000276837.1 ENSMUSG00000126524 (from geneSymbol) uc333ehr.1 uc333ehr.1 
ENSMUST00000276839.1 ENSMUSG00000126525 ENSMUST00000276839.1 ENSMUSG00000126525 (from geneSymbol) uc333eht.1 uc333eht.1 
ENSMUST00000276845.1 ENSMUSG00000126526 ENSMUST00000276845.1 ENSMUSG00000126526 (from geneSymbol) BC023277 uc333ehx.1 uc333ehx.1 
ENSMUST00000276848.1 ENSMUSG00000126527 ENSMUST00000276848.1 ENSMUSG00000126527 (from geneSymbol) uc333eia.1 uc333eia.1 
ENSMUST00000276852.1 ENSMUSG00000126529 ENSMUST00000276852.1 ENSMUSG00000126529 (from geneSymbol) uc333eid.1 uc333eid.1 
ENSMUST00000276853.1 ENSMUSG00000126530 ENSMUST00000276853.1 ENSMUSG00000126530 (from geneSymbol) AK036683 uc333eie.1 uc333eie.1 
ENSMUST00000276860.1 ENSMUSG00000126531 ENSMUST00000276860.1 ENSMUSG00000126531 (from geneSymbol) uc333eil.1 uc333eil.1 
ENSMUST00000276873.1 ENSMUSG00000126532 ENSMUST00000276873.1 ENSMUSG00000126532 (from geneSymbol) uc333eiy.1 uc333eiy.1 
ENSMUST00000276875.1 Gm38604 ENSMUST00000276875.1 Gm38604 (from geneSymbol) AK138291 uc333eja.1 uc333eja.1 
ENSMUST00000276889.1 Gm43701 ENSMUST00000276889.1 Gm43701 (from geneSymbol) AK076868 uc333ejo.1 uc333ejo.1 
ENSMUST00000276890.1 ENSMUSG00000126533 ENSMUST00000276890.1 ENSMUSG00000126533 (from geneSymbol) uc333ejp.1 uc333ejp.1 
ENSMUST00000276891.1 Gm49211 ENSMUST00000276891.1 Gm49211 (from geneSymbol) uc333ejq.1 uc333ejq.1 
ENSMUST00000276894.1 ENSMUSG00000126534 ENSMUST00000276894.1 ENSMUSG00000126534 (from geneSymbol) uc333ejt.1 uc333ejt.1 
ENSMUST00000276895.1 ENSMUSG00000126535 ENSMUST00000276895.1 ENSMUSG00000126535 (from geneSymbol) uc333eju.1 uc333eju.1 
ENSMUST00000276896.1 ENSMUSG00000126536 ENSMUST00000276896.1 ENSMUSG00000126536 (from geneSymbol) uc333ejv.1 uc333ejv.1 
ENSMUST00000276902.1 ENSMUSG00000126537 ENSMUST00000276902.1 ENSMUSG00000126537 (from geneSymbol) uc333ekb.1 uc333ekb.1 
ENSMUST00000276917.1 ENSMUSG00000126538 ENSMUST00000276917.1 ENSMUSG00000126538 (from geneSymbol) uc333ekp.1 uc333ekp.1 
ENSMUST00000276918.1 ENSMUSG00000126539 ENSMUST00000276918.1 ENSMUSG00000126539 (from geneSymbol) uc333ekq.1 uc333ekq.1 
ENSMUST00000276922.1 ENSMUSG00000126540 ENSMUST00000276922.1 ENSMUSG00000126540 (from geneSymbol) AK132947 uc333eku.1 uc333eku.1 
ENSMUST00000276924.1 ENSMUSG00000126541 ENSMUST00000276924.1 ENSMUSG00000126541 (from geneSymbol) uc333ekw.1 uc333ekw.1 
ENSMUST00000276927.1 ENSMUSG00000126542 ENSMUST00000276927.1 ENSMUSG00000126542 (from geneSymbol) uc333ekz.1 uc333ekz.1 
ENSMUST00000276928.1 ENSMUSG00000126543 ENSMUST00000276928.1 ENSMUSG00000126543 (from geneSymbol) uc333ela.1 uc333ela.1 
ENSMUST00000276929.1 ENSMUSG00000126544 ENSMUST00000276929.1 ENSMUSG00000126544 (from geneSymbol) uc333elb.1 uc333elb.1 
ENSMUST00000276930.1 ENSMUSG00000126545 ENSMUST00000276930.1 ENSMUSG00000126545 (from geneSymbol) uc333elc.1 uc333elc.1 
ENSMUST00000276931.1 ENSMUSG00000126546 ENSMUST00000276931.1 ENSMUSG00000126546 (from geneSymbol) uc333eld.1 uc333eld.1 
ENSMUST00000276932.1 ENSMUSG00000126547 ENSMUST00000276932.1 ENSMUSG00000126547 (from geneSymbol) uc333ele.1 uc333ele.1 
ENSMUST00000276942.1 ENSMUSG00000126548 ENSMUST00000276942.1 ENSMUSG00000126548 (from geneSymbol) uc333elo.1 uc333elo.1 
ENSMUST00000276943.1 ENSMUSG00000126549 ENSMUST00000276943.1 ENSMUSG00000126549 (from geneSymbol) uc333elp.1 uc333elp.1 
ENSMUST00000276945.1 Gm56659 ENSMUST00000276945.1 predicted gene, 35782, transcript variant 2 (from RefSeq NR_176638.1) NR_176638 uc333elr.1 uc333elr.1 
ENSMUST00000276967.1 ENSMUSG00000126551 ENSMUST00000276967.1 ENSMUSG00000126551 (from geneSymbol) uc333emn.1 uc333emn.1 
ENSMUST00000276969.1 ENSMUSG00000126552 ENSMUST00000276969.1 ENSMUSG00000126552 (from geneSymbol) uc333emp.1 uc333emp.1 
ENSMUST00000276971.1 ENSMUSG00000126554 ENSMUST00000276971.1 ENSMUSG00000126554 (from geneSymbol) uc333emq.1 uc333emq.1 
ENSMUST00000276972.1 ENSMUSG00000126555 ENSMUST00000276972.1 ENSMUSG00000126555 (from geneSymbol) uc333emr.1 uc333emr.1 
ENSMUST00000276975.1 ENSMUSG00000126556 ENSMUST00000276975.1 ENSMUSG00000126556 (from geneSymbol) uc333emu.1 uc333emu.1 
ENSMUST00000276976.1 ENSMUSG00000126557 ENSMUST00000276976.1 ENSMUSG00000126557 (from geneSymbol) uc333emv.1 uc333emv.1 
ENSMUST00000276977.1 ENSMUSG00000126558 ENSMUST00000276977.1 ENSMUSG00000126558 (from geneSymbol) uc333emw.1 uc333emw.1 
ENSMUST00000276980.1 Gm57180 ENSMUST00000276980.1 Gm57180 (from geneSymbol) uc333emz.1 uc333emz.1 
ENSMUST00000276984.1 ENSMUSG00000126559 ENSMUST00000276984.1 ENSMUSG00000126559 (from geneSymbol) uc333end.1 uc333end.1 
ENSMUST00000276985.1 ENSMUSG00000126560 ENSMUST00000276985.1 ENSMUSG00000126560 (from geneSymbol) uc333ene.1 uc333ene.1 
ENSMUST00000276986.1 ENSMUSG00000126561 ENSMUST00000276986.1 ENSMUSG00000126561 (from geneSymbol) uc333enf.1 uc333enf.1 
ENSMUST00000276987.1 ENSMUSG00000126562 ENSMUST00000276987.1 ENSMUSG00000126562 (from geneSymbol) LF197835 uc333eng.1 uc333eng.1 
ENSMUST00000276988.1 ENSMUSG00000126563 ENSMUST00000276988.1 ENSMUSG00000126563 (from geneSymbol) uc333enh.1 uc333enh.1 
ENSMUST00000276990.1 ENSMUSG00000126564 ENSMUST00000276990.1 ENSMUSG00000126564 (from geneSymbol) uc333enj.1 uc333enj.1 
ENSMUST00000276993.1 1700025J12Rik ENSMUST00000276993.1 1700025J12Rik (from geneSymbol) AK006348 uc333enm.1 uc333enm.1 
ENSMUST00000277001.1 ENSMUSG00000126565 ENSMUST00000277001.1 ENSMUSG00000126565 (from geneSymbol) uc333enu.1 uc333enu.1 
ENSMUST00000277002.1 ENSMUSG00000126566 ENSMUST00000277002.1 ENSMUSG00000126566 (from geneSymbol) uc333env.1 uc333env.1 
ENSMUST00000277003.1 ENSMUSG00000126567 ENSMUST00000277003.1 ENSMUSG00000126567 (from geneSymbol) uc333enw.1 uc333enw.1 
ENSMUST00000277005.1 ENSMUSG00000126568 ENSMUST00000277005.1 ENSMUSG00000126568 (from geneSymbol) uc333eny.1 uc333eny.1 
ENSMUST00000277006.1 ENSMUSG00000126569 ENSMUST00000277006.1 ENSMUSG00000126569 (from geneSymbol) uc333enz.1 uc333enz.1 
ENSMUST00000277007.1 ENSMUSG00000126570 ENSMUST00000277007.1 ENSMUSG00000126570 (from geneSymbol) uc333eoa.1 uc333eoa.1 
ENSMUST00000277010.1 ENSMUSG00000126571 ENSMUST00000277010.1 ENSMUSG00000126571 (from geneSymbol) uc333eod.1 uc333eod.1 
ENSMUST00000277012.1 ENSMUSG00000126572 ENSMUST00000277012.1 ENSMUSG00000126572 (from geneSymbol) uc333eoe.1 uc333eoe.1 
ENSMUST00000277013.1 3110006O06Rik ENSMUST00000277013.1 3110006O06Rik (from geneSymbol) uc333eof.1 uc333eof.1 
ENSMUST00000277015.1 ENSMUSG00000126573 ENSMUST00000277015.1 ENSMUSG00000126573 (from geneSymbol) uc333eoh.1 uc333eoh.1 
ENSMUST00000277016.1 ENSMUSG00000126574 ENSMUST00000277016.1 ENSMUSG00000126574 (from geneSymbol) uc333eoi.1 uc333eoi.1 
ENSMUST00000277018.1 ENSMUSG00000126575 ENSMUST00000277018.1 ENSMUSG00000126575 (from geneSymbol) uc333eok.1 uc333eok.1 
ENSMUST00000277046.1 ENSMUSG00000126577 ENSMUST00000277046.1 ENSMUSG00000126577 (from geneSymbol) uc333eox.1 uc333eox.1 
ENSMUST00000277047.1 ENSMUSG00000126578 ENSMUST00000277047.1 ENSMUSG00000126578 (from geneSymbol) uc333eoy.1 uc333eoy.1 
ENSMUST00000277049.1 Gm47439 ENSMUST00000277049.1 Gm47439 (from geneSymbol) uc333epa.1 uc333epa.1 
ENSMUST00000277053.1 ENSMUSG00000126579 ENSMUST00000277053.1 ENSMUSG00000126579 (from geneSymbol) uc333epe.1 uc333epe.1 
ENSMUST00000277086.1 ENSMUSG00000126580 ENSMUST00000277086.1 ENSMUSG00000126580 (from geneSymbol) uc333eql.1 uc333eql.1 
ENSMUST00000277087.1 ENSMUSG00000126581 ENSMUST00000277087.1 ENSMUSG00000126581 (from geneSymbol) uc333eqm.1 uc333eqm.1 
ENSMUST00000277089.1 ENSMUSG00000126582 ENSMUST00000277089.1 ENSMUSG00000126582 (from geneSymbol) uc333eqo.1 uc333eqo.1 
ENSMUST00000277091.1 ENSMUSG00000126583 ENSMUST00000277091.1 ENSMUSG00000126583 (from geneSymbol) uc333eqq.1 uc333eqq.1 
ENSMUST00000277095.1 ENSMUSG00000126584 ENSMUST00000277095.1 ENSMUSG00000126584 (from geneSymbol) uc333equ.1 uc333equ.1 
ENSMUST00000277096.1 ENSMUSG00000126585 ENSMUST00000277096.1 ENSMUSG00000126585 (from geneSymbol) uc333eqv.1 uc333eqv.1 
ENSMUST00000277099.1 1700110I07Rik ENSMUST00000277099.1 1700110I07Rik (from geneSymbol) AK007160 uc333eqy.1 uc333eqy.1 
ENSMUST00000277214.1 ENSMUSG00000126586 ENSMUST00000277214.1 ENSMUSG00000126586 (from geneSymbol) uc333evi.1 uc333evi.1 
ENSMUST00000277215.1 ENSMUSG00000126587 ENSMUST00000277215.1 ENSMUSG00000126587 (from geneSymbol) uc333evj.1 uc333evj.1 
ENSMUST00000277217.1 ENSMUSG00000126588 ENSMUST00000277217.1 ENSMUSG00000126588 (from geneSymbol) uc333evl.1 uc333evl.1 
ENSMUST00000277220.1 ENSMUSG00000126589 ENSMUST00000277220.1 ENSMUSG00000126589 (from geneSymbol) uc333evo.1 uc333evo.1 
ENSMUST00000277221.1 ENSMUSG00000126590 ENSMUST00000277221.1 ENSMUSG00000126590 (from geneSymbol) uc333evp.1 uc333evp.1 
ENSMUST00000277222.1 ENSMUSG00000126591 ENSMUST00000277222.1 ENSMUSG00000126591 (from geneSymbol) uc333evq.1 uc333evq.1 
ENSMUST00000277229.1 ENSMUSG00000126592 ENSMUST00000277229.1 ENSMUSG00000126592 (from geneSymbol) uc333evx.1 uc333evx.1 
ENSMUST00000277230.1 ENSMUSG00000126593 ENSMUST00000277230.1 ENSMUSG00000126593 (from geneSymbol) uc333evy.1 uc333evy.1 
ENSMUST00000277233.1 ENSMUSG00000126594 ENSMUST00000277233.1 ENSMUSG00000126594 (from geneSymbol) BC019681 uc333ewb.1 uc333ewb.1 
ENSMUST00000277234.1 ENSMUSG00000126595 ENSMUST00000277234.1 ENSMUSG00000126595 (from geneSymbol) uc333ewc.1 uc333ewc.1 
ENSMUST00000277237.1 Gm29431 ENSMUST00000277237.1 Gm29431 (from geneSymbol) uc333ewf.1 uc333ewf.1 
ENSMUST00000277258.1 ENSMUSG00000126596 ENSMUST00000277258.1 ENSMUSG00000126596 (from geneSymbol) uc333exa.1 uc333exa.1 
ENSMUST00000277261.1 ENSMUSG00000126597 ENSMUST00000277261.1 ENSMUSG00000126597 (from geneSymbol) uc333exd.1 uc333exd.1 
ENSMUST00000277267.1 ENSMUSG00000126598 ENSMUST00000277267.1 ENSMUSG00000126598 (from geneSymbol) uc333exj.1 uc333exj.1 
ENSMUST00000277271.1 ENSMUSG00000126599 ENSMUST00000277271.1 ENSMUSG00000126599 (from geneSymbol) uc333exn.1 uc333exn.1 
ENSMUST00000277275.1 ENSMUSG00000126600 ENSMUST00000277275.1 ENSMUSG00000126600 (from geneSymbol) uc333exr.1 uc333exr.1 
ENSMUST00000277276.1 ENSMUSG00000126601 ENSMUST00000277276.1 ENSMUSG00000126601 (from geneSymbol) uc333exs.1 uc333exs.1 
ENSMUST00000277277.1 ENSMUSG00000126602 ENSMUST00000277277.1 ENSMUSG00000126602 (from geneSymbol) uc333ext.1 uc333ext.1 
ENSMUST00000277278.1 ENSMUSG00000126603 ENSMUST00000277278.1 ENSMUSG00000126603 (from geneSymbol) uc333exu.1 uc333exu.1 
ENSMUST00000277279.1 ENSMUSG00000126604 ENSMUST00000277279.1 ENSMUSG00000126604 (from geneSymbol) uc333exv.1 uc333exv.1 
ENSMUST00000277280.1 ENSMUSG00000126605 ENSMUST00000277280.1 ENSMUSG00000126605 (from geneSymbol) uc333exw.1 uc333exw.1 
ENSMUST00000277283.1 ENSMUSG00000126606 ENSMUST00000277283.1 ENSMUSG00000126606 (from geneSymbol) uc333exz.1 uc333exz.1 
ENSMUST00000277284.1 ENSMUSG00000126607 ENSMUST00000277284.1 ENSMUSG00000126607 (from geneSymbol) uc333eya.1 uc333eya.1 
ENSMUST00000277289.1 ENSMUSG00000126608 ENSMUST00000277289.1 ENSMUSG00000126608 (from geneSymbol) uc333eyf.1 uc333eyf.1 
ENSMUST00000277290.1 ENSMUSG00000126609 ENSMUST00000277290.1 ENSMUSG00000126609 (from geneSymbol) uc333eyg.1 uc333eyg.1 
ENSMUST00000277293.1 ENSMUSG00000126610 ENSMUST00000277293.1 ENSMUSG00000126610 (from geneSymbol) uc333eyj.1 uc333eyj.1 
ENSMUST00000277294.1 ENSMUSG00000126611 ENSMUST00000277294.1 ENSMUSG00000126611 (from geneSymbol) uc333eyk.1 uc333eyk.1 
ENSMUST00000277296.1 ENSMUSG00000126612 ENSMUST00000277296.1 ENSMUSG00000126612 (from geneSymbol) uc333eym.1 uc333eym.1 
ENSMUST00000277313.1 ENSMUSG00000126613 ENSMUST00000277313.1 ENSMUSG00000126613 (from geneSymbol) uc333ezc.1 uc333ezc.1 
ENSMUST00000277314.1 ENSMUSG00000126614 ENSMUST00000277314.1 ENSMUSG00000126614 (from geneSymbol) uc333ezd.1 uc333ezd.1 
ENSMUST00000277316.1 ENSMUSG00000126615 ENSMUST00000277316.1 ENSMUSG00000126615 (from geneSymbol) uc333ezf.1 uc333ezf.1 
ENSMUST00000277317.1 ENSMUSG00000126616 ENSMUST00000277317.1 ENSMUSG00000126616 (from geneSymbol) LF198759 uc333ezg.1 uc333ezg.1 
ENSMUST00000277320.1 Gm17102 ENSMUST00000277320.1 Gm17102 (from geneSymbol) AK163099 uc333ezj.1 uc333ezj.1 
ENSMUST00000277337.1 1700124M09Rik ENSMUST00000277337.1 1700124M09Rik (from geneSymbol) AK007272 uc333ezy.1 uc333ezy.1 
ENSMUST00000277348.1 ENSMUSG00000126617 ENSMUST00000277348.1 ENSMUSG00000126617 (from geneSymbol) uc333faj.1 uc333faj.1 
ENSMUST00000277352.1 ENSMUSG00000126619 ENSMUST00000277352.1 ENSMUSG00000126619 (from geneSymbol) uc333fam.1 uc333fam.1 
ENSMUST00000277357.1 ENSMUSG00000126620 ENSMUST00000277357.1 ENSMUSG00000126620 (from geneSymbol) uc333far.1 uc333far.1 
ENSMUST00000277360.1 ENSMUSG00000126621 ENSMUST00000277360.1 ENSMUSG00000126621 (from geneSymbol) uc333fau.1 uc333fau.1 
ENSMUST00000277362.1 ENSMUSG00000126622 ENSMUST00000277362.1 ENSMUSG00000126622 (from geneSymbol) uc333faw.1 uc333faw.1 
ENSMUST00000277366.1 ENSMUSG00000126623 ENSMUST00000277366.1 ENSMUSG00000126623 (from geneSymbol) uc333fba.1 uc333fba.1 
ENSMUST00000277374.1 ENSMUSG00000126624 ENSMUST00000277374.1 ENSMUSG00000126624 (from geneSymbol) uc333fbi.1 uc333fbi.1 
ENSMUST00000277375.1 ENSMUSG00000126625 ENSMUST00000277375.1 ENSMUSG00000126625 (from geneSymbol) uc333fbj.1 uc333fbj.1 
ENSMUST00000277376.1 ENSMUSG00000126626 ENSMUST00000277376.1 ENSMUSG00000126626 (from geneSymbol) uc333fbk.1 uc333fbk.1 
ENSMUST00000277377.1 Gm35430 ENSMUST00000277377.1 Gm35430 (from geneSymbol) uc333fbl.1 uc333fbl.1 
ENSMUST00000277378.1 ENSMUSG00000126627 ENSMUST00000277378.1 ENSMUSG00000126627 (from geneSymbol) uc333fbm.1 uc333fbm.1 
ENSMUST00000277380.1 Gm10605 ENSMUST00000277380.1 Gm10605 (from geneSymbol) uc333fbo.1 uc333fbo.1 
ENSMUST00000277389.1 ENSMUSG00000126628 ENSMUST00000277389.1 ENSMUSG00000126628 (from geneSymbol) uc333fbx.1 uc333fbx.1 
ENSMUST00000277403.1 ENSMUSG00000126629 ENSMUST00000277403.1 ENSMUSG00000126629 (from geneSymbol) LF201421 uc333fcl.1 uc333fcl.1 
ENSMUST00000277404.1 Gm46400 ENSMUST00000277404.1 Gm46400 (from geneSymbol) uc333fcm.1 uc333fcm.1 
ENSMUST00000277413.1 ENSMUSG00000126630 ENSMUST00000277413.1 ENSMUSG00000126630 (from geneSymbol) uc333fcv.1 uc333fcv.1 
ENSMUST00000277414.1 ENSMUSG00000126631 ENSMUST00000277414.1 ENSMUSG00000126631 (from geneSymbol) uc333fcw.1 uc333fcw.1 
ENSMUST00000277415.1 ENSMUSG00000126632 ENSMUST00000277415.1 ENSMUSG00000126632 (from geneSymbol) uc333fcx.1 uc333fcx.1 
ENSMUST00000277417.1 ENSMUSG00000126633 ENSMUST00000277417.1 ENSMUSG00000126633 (from geneSymbol) KX852424 uc333fcz.1 uc333fcz.1 
ENSMUST00000277433.1 ENSMUSG00000126634 ENSMUST00000277433.1 ENSMUSG00000126634 (from geneSymbol) uc333fdp.1 uc333fdp.1 
ENSMUST00000277434.1 ENSMUSG00000126635 ENSMUST00000277434.1 ENSMUSG00000126635 (from geneSymbol) uc333fdq.1 uc333fdq.1 
ENSMUST00000277435.1 ENSMUSG00000126636 ENSMUST00000277435.1 ENSMUSG00000126636 (from geneSymbol) uc333fdr.1 uc333fdr.1 
ENSMUST00000277444.1 ENSMUSG00000126637 ENSMUST00000277444.1 ENSMUSG00000126637 (from geneSymbol) uc333fea.1 uc333fea.1 
ENSMUST00000277445.1 ENSMUSG00000126638 ENSMUST00000277445.1 ENSMUSG00000126638 (from geneSymbol) uc333feb.1 uc333feb.1 
ENSMUST00000277468.1 ENSMUSG00000126639 ENSMUST00000277468.1 ENSMUSG00000126639 (from geneSymbol) uc333fey.1 uc333fey.1 
ENSMUST00000277469.1 ENSMUSG00000126640 ENSMUST00000277469.1 ENSMUSG00000126640 (from geneSymbol) uc333fez.1 uc333fez.1 
ENSMUST00000277470.1 ENSMUSG00000126641 ENSMUST00000277470.1 ENSMUSG00000126641 (from geneSymbol) AK018981 uc333ffa.1 uc333ffa.1 
ENSMUST00000277471.1 ENSMUSG00000126642 ENSMUST00000277471.1 ENSMUSG00000126642 (from geneSymbol) uc333ffb.1 uc333ffb.1 
ENSMUST00000277472.1 ENSMUSG00000126643 ENSMUST00000277472.1 ENSMUSG00000126643 (from geneSymbol) uc333ffc.1 uc333ffc.1 
ENSMUST00000277475.1 ENSMUSG00000126645 ENSMUST00000277475.1 ENSMUSG00000126645 (from geneSymbol) uc333fff.1 uc333fff.1 
ENSMUST00000277478.1 ENSMUSG00000126644 ENSMUST00000277478.1 ENSMUSG00000126644 (from geneSymbol) uc333ffi.1 uc333ffi.1 
ENSMUST00000277480.1 ENSMUSG00000126646 ENSMUST00000277480.1 ENSMUSG00000126646 (from geneSymbol) uc333ffk.1 uc333ffk.1 
ENSMUST00000277481.1 ENSMUSG00000126647 ENSMUST00000277481.1 ENSMUSG00000126647 (from geneSymbol) uc333ffl.1 uc333ffl.1 
ENSMUST00000277483.1 ENSMUSG00000126648 ENSMUST00000277483.1 ENSMUSG00000126648 (from geneSymbol) uc333ffn.1 uc333ffn.1 
ENSMUST00000277495.1 ENSMUSG00000126649 ENSMUST00000277495.1 ENSMUSG00000126649 (from geneSymbol) uc333ffz.1 uc333ffz.1 
ENSMUST00000277497.1 ENSMUSG00000126650 ENSMUST00000277497.1 ENSMUSG00000126650 (from geneSymbol) uc333fgb.1 uc333fgb.1 
ENSMUST00000277500.1 ENSMUSG00000126651 ENSMUST00000277500.1 ENSMUSG00000126651 (from geneSymbol) uc333fge.1 uc333fge.1 
ENSMUST00000277503.1 ENSMUSG00000126652 ENSMUST00000277503.1 ENSMUSG00000126652 (from geneSymbol) uc333fgh.1 uc333fgh.1 
ENSMUST00000277505.1 ENSMUSG00000126653 ENSMUST00000277505.1 ENSMUSG00000126653 (from geneSymbol) uc333fgj.1 uc333fgj.1 
ENSMUST00000277507.1 ENSMUSG00000126654 ENSMUST00000277507.1 ENSMUSG00000126654 (from geneSymbol) uc333fgl.1 uc333fgl.1 
ENSMUST00000277513.1 ENSMUSG00000126655 ENSMUST00000277513.1 ENSMUSG00000126655 (from geneSymbol) uc333fgr.1 uc333fgr.1 
ENSMUST00000277515.1 ENSMUSG00000126656 ENSMUST00000277515.1 ENSMUSG00000126656 (from geneSymbol) uc333fgt.1 uc333fgt.1 
ENSMUST00000277516.1 ENSMUSG00000126657 ENSMUST00000277516.1 ENSMUSG00000126657 (from geneSymbol) uc333fgu.1 uc333fgu.1 
ENSMUST00000277517.1 ENSMUSG00000126658 ENSMUST00000277517.1 ENSMUSG00000126658 (from geneSymbol) uc333fgv.1 uc333fgv.1 
ENSMUST00000277518.1 ENSMUSG00000126659 ENSMUST00000277518.1 ENSMUSG00000126659 (from geneSymbol) uc333fgw.1 uc333fgw.1 
ENSMUST00000277519.1 ENSMUSG00000126660 ENSMUST00000277519.1 ENSMUSG00000126660 (from geneSymbol) uc333fgx.1 uc333fgx.1 
ENSMUST00000277520.1 ENSMUSG00000126661 ENSMUST00000277520.1 ENSMUSG00000126661 (from geneSymbol) uc333fgy.1 uc333fgy.1 
ENSMUST00000277522.1 ENSMUSG00000126662 ENSMUST00000277522.1 ENSMUSG00000126662 (from geneSymbol) uc333fha.1 uc333fha.1 
ENSMUST00000277523.1 ENSMUSG00000126663 ENSMUST00000277523.1 ENSMUSG00000126663 (from geneSymbol) KY467726 uc333fhb.1 uc333fhb.1 
ENSMUST00000277525.1 ENSMUSG00000126664 ENSMUST00000277525.1 ENSMUSG00000126664 (from geneSymbol) uc333fhd.1 uc333fhd.1 
ENSMUST00000277526.1 ENSMUSG00000126665 ENSMUST00000277526.1 ENSMUSG00000126665 (from geneSymbol) uc333fhe.1 uc333fhe.1 
ENSMUST00000277529.1 Gm47733 ENSMUST00000277529.1 Gm47733 (from geneSymbol) uc333fhh.1 uc333fhh.1 
ENSMUST00000277531.1 ENSMUSG00000126666 ENSMUST00000277531.1 ENSMUSG00000126666 (from geneSymbol) uc333fhj.1 uc333fhj.1 
ENSMUST00000277539.1 ENSMUSG00000126667 ENSMUST00000277539.1 ENSMUSG00000126667 (from geneSymbol) uc333fhr.1 uc333fhr.1 
ENSMUST00000277547.1 ENSMUSG00000126668 ENSMUST00000277547.1 ENSMUSG00000126668 (from geneSymbol) uc333fhz.1 uc333fhz.1 
ENSMUST00000277553.1 Gm15657 ENSMUST00000277553.1 Gm15657 (from geneSymbol) AK153575 uc333fif.1 uc333fif.1 
ENSMUST00000277559.1 ENSMUSG00000126669 ENSMUST00000277559.1 ENSMUSG00000126669 (from geneSymbol) uc333fil.1 uc333fil.1 
ENSMUST00000277560.1 ENSMUSG00000126670 ENSMUST00000277560.1 ENSMUSG00000126670 (from geneSymbol) uc333fim.1 uc333fim.1 
ENSMUST00000277573.1 Gm4961 ENSMUST00000277573.1 Gm4961 (from geneSymbol) AK139799 uc333fiy.1 uc333fiy.1 
ENSMUST00000277574.1 ENSMUSG00000126672 ENSMUST00000277574.1 ENSMUSG00000126672 (from geneSymbol) uc333fiz.1 uc333fiz.1 
ENSMUST00000277576.1 ENSMUSG00000126673 ENSMUST00000277576.1 ENSMUSG00000126673 (from geneSymbol) uc333fjb.1 uc333fjb.1 
ENSMUST00000277579.1 2410021H03Rik ENSMUST00000277579.1 2410021H03Rik (from geneSymbol) AK010563 uc333fje.1 uc333fje.1 
ENSMUST00000277584.1 ENSMUSG00000126674 ENSMUST00000277584.1 ENSMUSG00000126674 (from geneSymbol) uc333fjj.1 uc333fjj.1 
ENSMUST00000277585.1 ENSMUSG00000126675 ENSMUST00000277585.1 ENSMUSG00000126675 (from geneSymbol) uc333fjk.1 uc333fjk.1 
ENSMUST00000277588.1 ENSMUSG00000126676 ENSMUST00000277588.1 ENSMUSG00000126676 (from geneSymbol) uc333fjn.1 uc333fjn.1 
ENSMUST00000277593.1 ENSMUSG00000126677 ENSMUST00000277593.1 ENSMUSG00000126677 (from geneSymbol) uc333fjs.1 uc333fjs.1 
ENSMUST00000277594.1 ENSMUSG00000126678 ENSMUST00000277594.1 ENSMUSG00000126678 (from geneSymbol) uc333fjt.1 uc333fjt.1 
ENSMUST00000277595.1 ENSMUSG00000126679 ENSMUST00000277595.1 ENSMUSG00000126679 (from geneSymbol) uc333fju.1 uc333fju.1 
ENSMUST00000277597.1 ENSMUSG00000126680 ENSMUST00000277597.1 ENSMUSG00000126680 (from geneSymbol) uc333fjw.1 uc333fjw.1 
ENSMUST00000277599.1 ENSMUSG00000126681 ENSMUST00000277599.1 ENSMUSG00000126681 (from geneSymbol) uc333fjy.1 uc333fjy.1 
ENSMUST00000277600.1 ENSMUSG00000126682 ENSMUST00000277600.1 ENSMUSG00000126682 (from geneSymbol) uc333fjz.1 uc333fjz.1 
ENSMUST00000277601.1 ENSMUSG00000126683 ENSMUST00000277601.1 ENSMUSG00000126683 (from geneSymbol) uc333fka.1 uc333fka.1 
ENSMUST00000277605.1 ENSMUSG00000126684 ENSMUST00000277605.1 ENSMUSG00000126684 (from geneSymbol) uc333fke.1 uc333fke.1 
ENSMUST00000277606.1 ENSMUSG00000126685 ENSMUST00000277606.1 ENSMUSG00000126685 (from geneSymbol) uc333fkf.1 uc333fkf.1 
ENSMUST00000277607.1 ENSMUSG00000126686 ENSMUST00000277607.1 ENSMUSG00000126686 (from geneSymbol) uc333fkg.1 uc333fkg.1 
ENSMUST00000277610.1 ENSMUSG00000126687 ENSMUST00000277610.1 ENSMUSG00000126687 (from geneSymbol) uc333fkj.1 uc333fkj.1 
ENSMUST00000277611.1 C330024D21Rik ENSMUST00000277611.1 C330024D21Rik (from geneSymbol) AK049146 uc333fkk.1 uc333fkk.1 
ENSMUST00000277626.1 ENSMUSG00000126688 ENSMUST00000277626.1 ENSMUSG00000126688 (from geneSymbol) uc333fkz.1 uc333fkz.1 
ENSMUST00000277631.1 ENSMUSG00000126689 ENSMUST00000277631.1 ENSMUSG00000126689 (from geneSymbol) uc333fld.1 uc333fld.1 
ENSMUST00000277648.1 ENSMUSG00000126690 ENSMUST00000277648.1 ENSMUSG00000126690 (from geneSymbol) uc333flu.1 uc333flu.1 
ENSMUST00000277652.1 ENSMUSG00000126691 ENSMUST00000277652.1 ENSMUSG00000126691 (from geneSymbol) uc333fly.1 uc333fly.1 
ENSMUST00000277654.1 ENSMUSG00000126692 ENSMUST00000277654.1 ENSMUSG00000126692 (from geneSymbol) uc333fma.1 uc333fma.1 
ENSMUST00000277656.1 Gm20275 ENSMUST00000277656.1 Gm20275 (from geneSymbol) AK168746 uc333fmc.1 uc333fmc.1 
ENSMUST00000277692.1 ENSMUSG00000126693 ENSMUST00000277692.1 ENSMUSG00000126693 (from geneSymbol) uc333fnm.1 uc333fnm.1 
ENSMUST00000277693.1 ENSMUSG00000126694 ENSMUST00000277693.1 ENSMUSG00000126694 (from geneSymbol) uc333fnn.1 uc333fnn.1 
ENSMUST00000277694.1 ENSMUSG00000126695 ENSMUST00000277694.1 ENSMUSG00000126695 (from geneSymbol) uc333fno.1 uc333fno.1 
ENSMUST00000277697.1 ENSMUSG00000126696 ENSMUST00000277697.1 ENSMUSG00000126696 (from geneSymbol) uc333fnr.1 uc333fnr.1 
ENSMUST00000277698.1 ENSMUSG00000126697 ENSMUST00000277698.1 ENSMUSG00000126697 (from geneSymbol) uc333fns.1 uc333fns.1 
ENSMUST00000277701.1 ENSMUSG00000126698 ENSMUST00000277701.1 ENSMUSG00000126698 (from geneSymbol) uc333fnv.1 uc333fnv.1 
ENSMUST00000277703.1 ENSMUSG00000126699 ENSMUST00000277703.1 ENSMUSG00000126699 (from geneSymbol) uc333fnx.1 uc333fnx.1 
ENSMUST00000277706.1 ENSMUSG00000126700 ENSMUST00000277706.1 ENSMUSG00000126700 (from geneSymbol) uc333foa.1 uc333foa.1 
ENSMUST00000277739.1 ENSMUSG00000126701 ENSMUST00000277739.1 ENSMUSG00000126701 (from geneSymbol) uc333fph.1 uc333fph.1 
ENSMUST00000277740.1 ENSMUSG00000126702 ENSMUST00000277740.1 ENSMUSG00000126702 (from geneSymbol) uc333fpi.1 uc333fpi.1 
ENSMUST00000277741.1 ENSMUSG00000126703 ENSMUST00000277741.1 ENSMUSG00000126703 (from geneSymbol) uc333fpj.1 uc333fpj.1 
ENSMUST00000277742.1 ENSMUSG00000126704 ENSMUST00000277742.1 ENSMUSG00000126704 (from geneSymbol) uc333fpk.1 uc333fpk.1 
ENSMUST00000277745.1 ENSMUSG00000126705 ENSMUST00000277745.1 ENSMUSG00000126705 (from geneSymbol) uc333fpn.1 uc333fpn.1 
ENSMUST00000277746.1 ENSMUSG00000126706 ENSMUST00000277746.1 ENSMUSG00000126706 (from geneSymbol) uc333fpo.1 uc333fpo.1 
ENSMUST00000277747.1 ENSMUSG00000126707 ENSMUST00000277747.1 ENSMUSG00000126707 (from geneSymbol) uc333fpp.1 uc333fpp.1 
ENSMUST00000277749.1 ENSMUSG00000126708 ENSMUST00000277749.1 ENSMUSG00000126708 (from geneSymbol) uc333fpr.1 uc333fpr.1 
ENSMUST00000277751.1 ENSMUSG00000126709 ENSMUST00000277751.1 ENSMUSG00000126709 (from geneSymbol) uc333fpt.1 uc333fpt.1 
ENSMUST00000277754.1 ENSMUSG00000126710 ENSMUST00000277754.1 ENSMUSG00000126710 (from geneSymbol) uc333fpw.1 uc333fpw.1 
ENSMUST00000277763.1 ENSMUSG00000126711 ENSMUST00000277763.1 ENSMUSG00000126711 (from geneSymbol) uc333fqf.1 uc333fqf.1 
ENSMUST00000277767.1 ENSMUSG00000126712 ENSMUST00000277767.1 ENSMUSG00000126712 (from geneSymbol) uc333fqj.1 uc333fqj.1 
ENSMUST00000277770.1 ENSMUSG00000126713 ENSMUST00000277770.1 ENSMUSG00000126713 (from geneSymbol) uc333fqm.1 uc333fqm.1 
ENSMUST00000277772.1 ENSMUSG00000126714 ENSMUST00000277772.1 ENSMUSG00000126714 (from geneSymbol) uc333fqo.1 uc333fqo.1 
ENSMUST00000277775.1 ENSMUSG00000126715 ENSMUST00000277775.1 ENSMUSG00000126715 (from geneSymbol) uc333fqr.1 uc333fqr.1 
ENSMUST00000277780.1 ENSMUSG00000126716 ENSMUST00000277780.1 ENSMUSG00000126716 (from geneSymbol) uc333fqw.1 uc333fqw.1 
ENSMUST00000277789.1 4930448H16Rik ENSMUST00000277789.1 4930448H16Rik (from geneSymbol) AK015418 uc333frf.1 uc333frf.1 
ENSMUST00000277797.1 Gm12061 ENSMUST00000277797.1 Gm12061 (from geneSymbol) uc333frn.1 uc333frn.1 
ENSMUST00000277802.1 ENSMUSG00000126717 ENSMUST00000277802.1 ENSMUSG00000126717 (from geneSymbol) uc333frs.1 uc333frs.1 
ENSMUST00000277805.1 ENSMUSG00000126718 ENSMUST00000277805.1 ENSMUSG00000126718 (from geneSymbol) uc333frv.1 uc333frv.1 
ENSMUST00000277808.1 ENSMUSG00000126719 ENSMUST00000277808.1 ENSMUSG00000126719 (from geneSymbol) uc333fry.1 uc333fry.1 
ENSMUST00000277812.1 ENSMUSG00000126720 ENSMUST00000277812.1 ENSMUSG00000126720 (from geneSymbol) uc333fsc.1 uc333fsc.1 
ENSMUST00000277813.1 ENSMUSG00000126721 ENSMUST00000277813.1 ENSMUSG00000126721 (from geneSymbol) uc333fsd.1 uc333fsd.1 
ENSMUST00000277817.1 ENSMUSG00000126722 ENSMUST00000277817.1 ENSMUSG00000126722 (from geneSymbol) uc333fsh.1 uc333fsh.1 
ENSMUST00000277819.1 ENSMUSG00000126723 ENSMUST00000277819.1 ENSMUSG00000126723 (from geneSymbol) uc333fsj.1 uc333fsj.1 
ENSMUST00000277821.1 ENSMUSG00000126725 ENSMUST00000277821.1 ENSMUSG00000126725 (from geneSymbol) uc333fsk.1 uc333fsk.1 
ENSMUST00000277823.1 ENSMUSG00000126726 ENSMUST00000277823.1 ENSMUSG00000126726 (from geneSymbol) uc333fsm.1 uc333fsm.1 
ENSMUST00000277831.1 ENSMUSG00000126727 ENSMUST00000277831.1 ENSMUSG00000126727 (from geneSymbol) uc333fsu.1 uc333fsu.1 
ENSMUST00000277836.1 Gm27217 ENSMUST00000277836.1 Gm27217 (from geneSymbol) AK139095 uc333fsz.1 uc333fsz.1 
ENSMUST00000277841.1 ENSMUSG00000126728 ENSMUST00000277841.1 ENSMUSG00000126728 (from geneSymbol) uc333fte.1 uc333fte.1 
ENSMUST00000277842.1 ENSMUSG00000126729 ENSMUST00000277842.1 ENSMUSG00000126729 (from geneSymbol) uc333ftf.1 uc333ftf.1 
ENSMUST00000277844.1 ENSMUSG00000126730 ENSMUST00000277844.1 ENSMUSG00000126730 (from geneSymbol) uc333fth.1 uc333fth.1 
ENSMUST00000277845.1 ENSMUSG00000126731 ENSMUST00000277845.1 ENSMUSG00000126731 (from geneSymbol) uc333fti.1 uc333fti.1 
ENSMUST00000277848.1 ENSMUSG00000126732 ENSMUST00000277848.1 ENSMUSG00000126732 (from geneSymbol) uc333ftl.1 uc333ftl.1 
ENSMUST00000277854.1 Gm47552 ENSMUST00000277854.1 Gm47552 (from geneSymbol) uc333ftr.1 uc333ftr.1 
ENSMUST00000277857.1 ENSMUSG00000126733 ENSMUST00000277857.1 ENSMUSG00000126733 (from geneSymbol) uc333ftu.1 uc333ftu.1 
ENSMUST00000277859.1 Gm10010 ENSMUST00000277859.1 Gm10010 (from geneSymbol) AK033854 uc333ftw.1 uc333ftw.1 
ENSMUST00000277880.1 ENSMUSG00000126734 ENSMUST00000277880.1 ENSMUSG00000126734 (from geneSymbol) uc333fur.1 uc333fur.1 
ENSMUST00000277883.1 ENSMUSG00000126735 ENSMUST00000277883.1 ENSMUSG00000126735 (from geneSymbol) uc333fuu.1 uc333fuu.1 
ENSMUST00000277886.1 ENSMUSG00000126736 ENSMUST00000277886.1 ENSMUSG00000126736 (from geneSymbol) uc333fux.1 uc333fux.1 
ENSMUST00000277888.1 ENSMUSG00000126737 ENSMUST00000277888.1 ENSMUSG00000126737 (from geneSymbol) uc333fuz.1 uc333fuz.1 
ENSMUST00000277889.1 ENSMUSG00000126738 ENSMUST00000277889.1 ENSMUSG00000126738 (from geneSymbol) uc333fva.1 uc333fva.1 
ENSMUST00000277896.1 Gm11508 ENSMUST00000277896.1 Gm11508 (from geneSymbol) uc333fvf.1 uc333fvf.1 
ENSMUST00000277925.1 Ccdc42os ENSMUST00000277925.1 Ccdc42os (from geneSymbol) AK015975 uc333fwi.1 uc333fwi.1 
ENSMUST00000277934.1 ENSMUSG00000126739 ENSMUST00000277934.1 ENSMUSG00000126739 (from geneSymbol) uc333fwr.1 uc333fwr.1 
ENSMUST00000277935.1 ENSMUSG00000126740 ENSMUST00000277935.1 ENSMUSG00000126740 (from geneSymbol) uc333fws.1 uc333fws.1 
ENSMUST00000277936.1 ENSMUSG00000126741 ENSMUST00000277936.1 ENSMUSG00000126741 (from geneSymbol) uc333fwt.1 uc333fwt.1 
ENSMUST00000277938.1 ENSMUSG00000126742 ENSMUST00000277938.1 ENSMUSG00000126742 (from geneSymbol) LF195129 uc333fwv.1 uc333fwv.1 
ENSMUST00000277939.1 ENSMUSG00000126743 ENSMUST00000277939.1 ENSMUSG00000126743 (from geneSymbol) uc333fww.1 uc333fww.1 
ENSMUST00000277940.1 ENSMUSG00000126744 ENSMUST00000277940.1 ENSMUSG00000126744 (from geneSymbol) uc333fwx.1 uc333fwx.1 
ENSMUST00000277949.1 ENSMUSG00000126745 ENSMUST00000277949.1 ENSMUSG00000126745 (from geneSymbol) uc333fxg.1 uc333fxg.1 
ENSMUST00000277951.1 Gm41361 ENSMUST00000277951.1 Gm41361 (from geneSymbol) uc333fxi.1 uc333fxi.1 
ENSMUST00000277955.1 ENSMUSG00000126746 ENSMUST00000277955.1 ENSMUSG00000126746 (from geneSymbol) AK158836 uc333fxm.1 uc333fxm.1 
ENSMUST00000277957.1 ENSMUSG00000126747 ENSMUST00000277957.1 ENSMUSG00000126747 (from geneSymbol) uc333fxo.1 uc333fxo.1 
ENSMUST00000277960.1 ENSMUSG00000126748 ENSMUST00000277960.1 ENSMUSG00000126748 (from geneSymbol) uc333fxr.1 uc333fxr.1 
ENSMUST00000277967.1 ENSMUSG00000126749 ENSMUST00000277967.1 ENSMUSG00000126749 (from geneSymbol) uc333fxy.1 uc333fxy.1 
ENSMUST00000277971.1 Gm40645 ENSMUST00000277971.1 Gm40645 (from geneSymbol) uc333fyc.1 uc333fyc.1 
ENSMUST00000277983.1 ENSMUSG00000126750 ENSMUST00000277983.1 ENSMUSG00000126750 (from geneSymbol) AB341774 uc333fyo.1 uc333fyo.1 
ENSMUST00000277984.1 ENSMUSG00000126751 ENSMUST00000277984.1 ENSMUSG00000126751 (from geneSymbol) uc333fyp.1 uc333fyp.1 
ENSMUST00000277996.1 1700007H22Rik ENSMUST00000277996.1 1700007H22Rik (from geneSymbol) AK005715 uc333fzb.1 uc333fzb.1 
ENSMUST00000278017.1 ENSMUSG00000126752 ENSMUST00000278017.1 ENSMUSG00000126752 (from geneSymbol) uc333fzw.1 uc333fzw.1 
ENSMUST00000278018.1 ENSMUSG00000126753 ENSMUST00000278018.1 ENSMUSG00000126753 (from geneSymbol) uc333fzx.1 uc333fzx.1 
ENSMUST00000278019.1 A130014A01Rik ENSMUST00000278019.1 A130014A01Rik (from geneSymbol) uc333fzy.1 uc333fzy.1 
ENSMUST00000278020.1 ENSMUSG00000126754 ENSMUST00000278020.1 ENSMUSG00000126754 (from geneSymbol) uc333fzz.1 uc333fzz.1 
ENSMUST00000278021.1 ENSMUSG00000126755 ENSMUST00000278021.1 ENSMUSG00000126755 (from geneSymbol) uc333gaa.1 uc333gaa.1 
ENSMUST00000278023.1 ENSMUSG00000126756 ENSMUST00000278023.1 ENSMUSG00000126756 (from geneSymbol) uc333gac.1 uc333gac.1 
ENSMUST00000278024.1 ENSMUSG00000126757 ENSMUST00000278024.1 ENSMUSG00000126757 (from geneSymbol) uc333gad.1 uc333gad.1 
ENSMUST00000278026.1 ENSMUSG00000126758 ENSMUST00000278026.1 ENSMUSG00000126758 (from geneSymbol) uc333gaf.1 uc333gaf.1 
ENSMUST00000278029.1 ENSMUSG00000126759 ENSMUST00000278029.1 ENSMUSG00000126759 (from geneSymbol) uc333gai.1 uc333gai.1 
ENSMUST00000278030.1 ENSMUSG00000126760 ENSMUST00000278030.1 ENSMUSG00000126760 (from geneSymbol) uc333gaj.1 uc333gaj.1 
ENSMUST00000278031.1 ENSMUSG00000126761 ENSMUST00000278031.1 ENSMUSG00000126761 (from geneSymbol) uc333gak.1 uc333gak.1 
ENSMUST00000278034.1 Gm6410 ENSMUST00000278034.1 Gm6410 (from geneSymbol) AK132693 uc333gan.1 uc333gan.1 
ENSMUST00000278037.1 ENSMUSG00000126762 ENSMUST00000278037.1 ENSMUSG00000126762 (from geneSymbol) uc333gaq.1 uc333gaq.1 
ENSMUST00000278038.1 ENSMUSG00000126763 ENSMUST00000278038.1 ENSMUSG00000126763 (from geneSymbol) uc333gar.1 uc333gar.1 
ENSMUST00000278040.1 ENSMUSG00000126764 ENSMUST00000278040.1 ENSMUSG00000126764 (from geneSymbol) uc333gat.1 uc333gat.1 
ENSMUST00000278042.1 ENSMUSG00000126765 ENSMUST00000278042.1 ENSMUSG00000126765 (from geneSymbol) uc333gav.1 uc333gav.1 
ENSMUST00000278043.1 ENSMUSG00000126766 ENSMUST00000278043.1 ENSMUSG00000126766 (from geneSymbol) uc333gaw.1 uc333gaw.1 
ENSMUST00000278046.1 ENSMUSG00000126767 ENSMUST00000278046.1 ENSMUSG00000126767 (from geneSymbol) uc333gaz.1 uc333gaz.1 
ENSMUST00000278047.1 ENSMUSG00000126768 ENSMUST00000278047.1 ENSMUSG00000126768 (from geneSymbol) uc333gba.1 uc333gba.1 
ENSMUST00000278049.1 ENSMUSG00000126769 ENSMUST00000278049.1 ENSMUSG00000126769 (from geneSymbol) uc333gbc.1 uc333gbc.1 
ENSMUST00000278053.1 ENSMUSG00000126770 ENSMUST00000278053.1 ENSMUSG00000126770 (from geneSymbol) uc333gbg.1 uc333gbg.1 
ENSMUST00000278055.1 ENSMUSG00000126771 ENSMUST00000278055.1 ENSMUSG00000126771 (from geneSymbol) uc333gbi.1 uc333gbi.1 
ENSMUST00000278056.1 ENSMUSG00000126772 ENSMUST00000278056.1 ENSMUSG00000126772 (from geneSymbol) uc333gbj.1 uc333gbj.1 
ENSMUST00000278060.1 ENSMUSG00000126773 ENSMUST00000278060.1 ENSMUSG00000126773 (from geneSymbol) uc333gbn.1 uc333gbn.1 
ENSMUST00000278062.1 ENSMUSG00000126774 ENSMUST00000278062.1 predicted gene, 51871, transcript variant 1 (from RefSeq NR_168574.1) NR_168574 uc333gbp.1 uc333gbp.1 
ENSMUST00000278064.1 ENSMUSG00000126775 ENSMUST00000278064.1 ENSMUSG00000126775 (from geneSymbol) uc333gbr.1 uc333gbr.1 
ENSMUST00000278065.1 ENSMUSG00000126776 ENSMUST00000278065.1 ENSMUSG00000126776 (from geneSymbol) uc333gbs.1 uc333gbs.1 
ENSMUST00000278066.1 ENSMUSG00000126777 ENSMUST00000278066.1 ENSMUSG00000126777 (from geneSymbol) uc333gbt.1 uc333gbt.1 
ENSMUST00000278079.1 ENSMUSG00000126778 ENSMUST00000278079.1 ENSMUSG00000126778 (from geneSymbol) uc333gcg.1 uc333gcg.1 
ENSMUST00000278080.1 ENSMUSG00000126779 ENSMUST00000278080.1 ENSMUSG00000126779 (from geneSymbol) uc333gch.1 uc333gch.1 
ENSMUST00000278081.1 ENSMUSG00000126780 ENSMUST00000278081.1 ENSMUSG00000126780 (from geneSymbol) uc333gci.1 uc333gci.1 
ENSMUST00000278082.1 Gm13782 ENSMUST00000278082.1 Gm13782 (from geneSymbol) uc333gcj.1 uc333gcj.1 
ENSMUST00000278083.1 ENSMUSG00000126781 ENSMUST00000278083.1 ENSMUSG00000126781 (from geneSymbol) uc333gck.1 uc333gck.1 
ENSMUST00000278085.1 ENSMUSG00000126782 ENSMUST00000278085.1 ENSMUSG00000126782 (from geneSymbol) uc333gcm.1 uc333gcm.1 
ENSMUST00000278090.1 1700011C11Rik ENSMUST00000278090.1 1700011C11Rik (from geneSymbol) AK005857 uc333gcr.1 uc333gcr.1 
ENSMUST00000278102.1 Gm43016 ENSMUST00000278102.1 Gm43016 (from geneSymbol) AK132670 uc333gdd.1 uc333gdd.1 
ENSMUST00000278114.1 ENSMUSG00000126783 ENSMUST00000278114.1 ENSMUSG00000126783 (from geneSymbol) uc333gdp.1 uc333gdp.1 
ENSMUST00000278130.1 Mirc35hg ENSMUST00000278130.1 microRNA cluster 35, host gene, transcript variant 1 (from RefSeq NR_126540.1) NR_126540 uc333gef.1 uc333gef.1 
ENSMUST00000278140.1 ENSMUSG00000126785 ENSMUST00000278140.1 ENSMUSG00000126785 (from geneSymbol) uc333gep.1 uc333gep.1 
ENSMUST00000278146.1 ENSMUSG00000126786 ENSMUST00000278146.1 ENSMUSG00000126786 (from geneSymbol) uc333gev.1 uc333gev.1 
ENSMUST00000278148.1 ENSMUSG00000126787 ENSMUST00000278148.1 ENSMUSG00000126787 (from geneSymbol) uc333gex.1 uc333gex.1 
ENSMUST00000278151.1 ENSMUSG00000126788 ENSMUST00000278151.1 ENSMUSG00000126788 (from geneSymbol) uc333gfa.1 uc333gfa.1 
ENSMUST00000278167.1 ENSMUSG00000126789 ENSMUST00000278167.1 ENSMUSG00000126789 (from geneSymbol) uc333gfo.1 uc333gfo.1 
ENSMUST00000278178.1 ENSMUSG00000126790 ENSMUST00000278178.1 ENSMUSG00000126790 (from geneSymbol) uc333gft.1 uc333gft.1 
ENSMUST00000278182.1 ENSMUSG00000126791 ENSMUST00000278182.1 ENSMUSG00000126791 (from geneSymbol) uc333gfx.1 uc333gfx.1 
ENSMUST00000278183.1 ENSMUSG00000126792 ENSMUST00000278183.1 ENSMUSG00000126792 (from geneSymbol) uc333gfy.1 uc333gfy.1 
ENSMUST00000278186.1 9530059O14Rik ENSMUST00000278186.1 9530059O14Rik (from geneSymbol) AK079255 uc333ggb.1 uc333ggb.1 
ENSMUST00000278228.1 ENSMUSG00000126793 ENSMUST00000278228.1 ENSMUSG00000126793 (from geneSymbol) uc333ghr.1 uc333ghr.1 
ENSMUST00000278229.1 ENSMUSG00000126794 ENSMUST00000278229.1 ENSMUSG00000126794 (from geneSymbol) uc333ghs.1 uc333ghs.1 
ENSMUST00000278230.1 ENSMUSG00000126795 ENSMUST00000278230.1 ENSMUSG00000126795 (from geneSymbol) uc333ght.1 uc333ght.1 
ENSMUST00000278234.1 ENSMUSG00000126796 ENSMUST00000278234.1 ENSMUSG00000126796 (from geneSymbol) uc333ghx.1 uc333ghx.1 
ENSMUST00000278244.1 ENSMUSG00000126798 ENSMUST00000278244.1 ENSMUSG00000126798 (from geneSymbol) uc333gig.1 uc333gig.1 
ENSMUST00000278245.1 ENSMUSG00000126799 ENSMUST00000278245.1 ENSMUSG00000126799 (from geneSymbol) uc333gih.1 uc333gih.1 
ENSMUST00000278249.1 ENSMUSG00000126800 ENSMUST00000278249.1 ENSMUSG00000126800 (from geneSymbol) uc333gil.1 uc333gil.1 
ENSMUST00000278260.1 Gm16404 ENSMUST00000278260.1 Gm16404 (from geneSymbol) BC171941 uc333giw.1 uc333giw.1 
ENSMUST00000278262.1 ENSMUSG00000126802 ENSMUST00000278262.1 ENSMUSG00000126802 (from geneSymbol) uc333giy.1 uc333giy.1 
ENSMUST00000278263.1 ENSMUSG00000126803 ENSMUST00000278263.1 ENSMUSG00000126803 (from geneSymbol) uc333giz.1 uc333giz.1 
ENSMUST00000278267.1 ENSMUSG00000126804 ENSMUST00000278267.1 ENSMUSG00000126804 (from geneSymbol) uc333gjd.1 uc333gjd.1 
ENSMUST00000278273.1 ENSMUSG00000126805 ENSMUST00000278273.1 ENSMUSG00000126805 (from geneSymbol) uc333gjj.1 uc333gjj.1 
ENSMUST00000278274.1 ENSMUSG00000126806 ENSMUST00000278274.1 ENSMUSG00000126806 (from geneSymbol) uc333gjk.1 uc333gjk.1 
ENSMUST00000278276.1 ENSMUSG00000126807 ENSMUST00000278276.1 ENSMUSG00000126807 (from geneSymbol) uc333gjm.1 uc333gjm.1 
ENSMUST00000278277.1 ENSMUSG00000126808 ENSMUST00000278277.1 ENSMUSG00000126808 (from geneSymbol) uc333gjn.1 uc333gjn.1 
ENSMUST00000278278.1 ENSMUSG00000126809 ENSMUST00000278278.1 ENSMUSG00000126809 (from geneSymbol) uc333gjo.1 uc333gjo.1 
ENSMUST00000278279.1 ENSMUSG00000126810 ENSMUST00000278279.1 ENSMUSG00000126810 (from geneSymbol) uc333gjp.1 uc333gjp.1 
ENSMUST00000278286.1 ENSMUSG00000126811 ENSMUST00000278286.1 ENSMUSG00000126811 (from geneSymbol) LF204561 uc333gjw.1 uc333gjw.1 
ENSMUST00000278287.1 ENSMUSG00000126812 ENSMUST00000278287.1 ENSMUSG00000126812 (from geneSymbol) uc333gjx.1 uc333gjx.1 
ENSMUST00000278291.1 ENSMUSG00000126813 ENSMUST00000278291.1 ENSMUSG00000126813 (from geneSymbol) uc333gkb.1 uc333gkb.1 
ENSMUST00000278295.1 ENSMUSG00000126814 ENSMUST00000278295.1 ENSMUSG00000126814 (from geneSymbol) uc333gkf.1 uc333gkf.1 
ENSMUST00000278296.1 ENSMUSG00000126815 ENSMUST00000278296.1 ENSMUSG00000126815 (from geneSymbol) uc333gkg.1 uc333gkg.1 
ENSMUST00000278308.1 ENSMUSG00000126816 ENSMUST00000278308.1 ENSMUSG00000126816 (from geneSymbol) uc333gks.1 uc333gks.1 
ENSMUST00000278314.1 ENSMUSG00000126817 ENSMUST00000278314.1 ENSMUSG00000126817 (from geneSymbol) uc333gky.1 uc333gky.1 
ENSMUST00000278315.1 ENSMUSG00000126818 ENSMUST00000278315.1 ENSMUSG00000126818 (from geneSymbol) AK076904 uc333gkz.1 uc333gkz.1 
ENSMUST00000278317.1 ENSMUSG00000121671 ENSMUST00000278317.1 ENSMUSG00000121671 (from geneSymbol) uc333glb.1 uc333glb.1 
ENSMUST00000278323.1 ENSMUSG00000126819 ENSMUST00000278323.1 ENSMUSG00000126819 (from geneSymbol) uc333glh.1 uc333glh.1 
ENSMUST00000278326.1 ENSMUSG00000126820 ENSMUST00000278326.1 ENSMUSG00000126820 (from geneSymbol) uc333glk.1 uc333glk.1 
ENSMUST00000278327.1 ENSMUSG00000126821 ENSMUST00000278327.1 ENSMUSG00000126821 (from geneSymbol) uc333gll.1 uc333gll.1 
ENSMUST00000278328.1 ENSMUSG00000126822 ENSMUST00000278328.1 ENSMUSG00000126822 (from geneSymbol) uc333glm.1 uc333glm.1 
ENSMUST00000278330.1 ENSMUSG00000126823 ENSMUST00000278330.1 ENSMUSG00000126823 (from geneSymbol) uc333glo.1 uc333glo.1 
ENSMUST00000278331.1 ENSMUSG00000126824 ENSMUST00000278331.1 ENSMUSG00000126824 (from geneSymbol) uc333glp.1 uc333glp.1 
ENSMUST00000278333.1 ENSMUSG00000126826 ENSMUST00000278333.1 ENSMUSG00000126826 (from geneSymbol) uc333glq.1 uc333glq.1 
ENSMUST00000278335.1 ENSMUSG00000126827 ENSMUST00000278335.1 ENSMUSG00000126827 (from geneSymbol) uc333gls.1 uc333gls.1 
ENSMUST00000278336.1 ENSMUSG00000126828 ENSMUST00000278336.1 ENSMUSG00000126828 (from geneSymbol) uc333glt.1 uc333glt.1 
ENSMUST00000278338.1 ENSMUSG00000126829 ENSMUST00000278338.1 ENSMUSG00000126829 (from geneSymbol) uc333glv.1 uc333glv.1 
ENSMUST00000278358.1 ENSMUSG00000126830 ENSMUST00000278358.1 ENSMUSG00000126830 (from geneSymbol) AK006015 uc333gmp.1 uc333gmp.1 
ENSMUST00000278368.1 ENSMUSG00000126831 ENSMUST00000278368.1 ENSMUSG00000126831 (from geneSymbol) uc333gmz.1 uc333gmz.1 
ENSMUST00000278369.1 ENSMUSG00000126832 ENSMUST00000278369.1 ENSMUSG00000126832 (from geneSymbol) uc333gna.1 uc333gna.1 
ENSMUST00000278370.1 ENSMUSG00000126833 ENSMUST00000278370.1 ENSMUSG00000126833 (from geneSymbol) uc333gnb.1 uc333gnb.1 
ENSMUST00000278372.1 ENSMUSG00000126834 ENSMUST00000278372.1 ENSMUSG00000126834 (from geneSymbol) uc333gnd.1 uc333gnd.1 
ENSMUST00000278379.1 ENSMUSG00000126835 ENSMUST00000278379.1 ENSMUSG00000126835 (from geneSymbol) uc333gnk.1 uc333gnk.1 
ENSMUST00000278381.1 ENSMUSG00000126836 ENSMUST00000278381.1 ENSMUSG00000126836 (from geneSymbol) uc333gnm.1 uc333gnm.1 
ENSMUST00000278383.1 ENSMUSG00000126837 ENSMUST00000278383.1 ENSMUSG00000126837 (from geneSymbol) uc333gno.1 uc333gno.1 
ENSMUST00000278385.1 ENSMUSG00000126838 ENSMUST00000278385.1 ENSMUSG00000126838 (from geneSymbol) uc333gnq.1 uc333gnq.1 
ENSMUST00000278386.1 Gm47136 ENSMUST00000278386.1 Gm47136 (from geneSymbol) uc333gnr.1 uc333gnr.1 
ENSMUST00000278387.1 ENSMUSG00000126839 ENSMUST00000278387.1 ENSMUSG00000126839 (from geneSymbol) uc333gns.1 uc333gns.1 
ENSMUST00000278388.1 ENSMUSG00000126840 ENSMUST00000278388.1 ENSMUSG00000126840 (from geneSymbol) uc333gnt.1 uc333gnt.1 
ENSMUST00000278389.1 ENSMUSG00000126841 ENSMUST00000278389.1 ENSMUSG00000126841 (from geneSymbol) uc333gnu.1 uc333gnu.1 
ENSMUST00000278394.1 Gm13236 ENSMUST00000278394.1 Gm13236 (from geneSymbol) BC096621 uc333gnx.1 uc333gnx.1 
ENSMUST00000278509.1 ENSMUSG00000126842 ENSMUST00000278509.1 ENSMUSG00000126842 (from geneSymbol) uc333gsi.1 uc333gsi.1 
ENSMUST00000278520.1 4930431P22Rik ENSMUST00000278520.1 4930431P22Rik (from geneSymbol) AK015281 uc333gst.1 uc333gst.1 
ENSMUST00000278530.1 1700087M22Rik ENSMUST00000278530.1 1700087M22Rik (from geneSymbol) AK018913 uc333gtd.1 uc333gtd.1 
ENSMUST00000278541.1 4930554C24Rik ENSMUST00000278541.1 4930554C24Rik (from geneSymbol) AK016115 uc333gto.1 uc333gto.1 
ENSMUST00000278549.1 ENSMUSG00000126843 ENSMUST00000278549.1 ENSMUSG00000126843 (from geneSymbol) uc333gtw.1 uc333gtw.1 
ENSMUST00000278555.1 ENSMUSG00000126844 ENSMUST00000278555.1 ENSMUSG00000126844 (from geneSymbol) uc333guc.1 uc333guc.1 
ENSMUST00000278558.1 ENSMUSG00000126845 ENSMUST00000278558.1 ENSMUSG00000126845 (from geneSymbol) uc333guf.1 uc333guf.1 
ENSMUST00000278564.1 ENSMUSG00000126846 ENSMUST00000278564.1 ENSMUSG00000126846 (from geneSymbol) uc333gul.1 uc333gul.1 
ENSMUST00000278565.1 ENSMUSG00000126847 ENSMUST00000278565.1 ENSMUSG00000126847 (from geneSymbol) uc333gum.1 uc333gum.1 
ENSMUST00000278567.1 ENSMUSG00000126848 ENSMUST00000278567.1 ENSMUSG00000126848 (from geneSymbol) uc333guo.1 uc333guo.1 
ENSMUST00000278569.1 ENSMUSG00000126849 ENSMUST00000278569.1 ENSMUSG00000126849 (from geneSymbol) uc333guq.1 uc333guq.1 
ENSMUST00000278570.1 Gm14302 ENSMUST00000278570.1 Gm14302 (from geneSymbol) uc333gur.1 uc333gur.1 
ENSMUST00000278572.1 ENSMUSG00000126850 ENSMUST00000278572.1 ENSMUSG00000126850 (from geneSymbol) uc333gut.1 uc333gut.1 
ENSMUST00000278573.1 Gm43177 ENSMUST00000278573.1 Gm43177 (from geneSymbol) uc333guu.1 uc333guu.1 
ENSMUST00000278574.1 ENSMUSG00000126851 ENSMUST00000278574.1 ENSMUSG00000126851 (from geneSymbol) uc333guv.1 uc333guv.1 
ENSMUST00000278575.1 ENSMUSG00000126852 ENSMUST00000278575.1 ENSMUSG00000126852 (from geneSymbol) uc333guw.1 uc333guw.1 
ENSMUST00000278576.1 ENSMUSG00000126853 ENSMUST00000278576.1 ENSMUSG00000126853 (from geneSymbol) uc333gux.1 uc333gux.1 
ENSMUST00000278580.1 ENSMUSG00000126854 ENSMUST00000278580.1 ENSMUSG00000126854 (from geneSymbol) uc333gvb.1 uc333gvb.1 
ENSMUST00000278602.1 4930401A07Rik ENSMUST00000278602.1 4930401A07Rik (from geneSymbol) AK015026 uc333gvx.1 uc333gvx.1 
ENSMUST00000278619.1 ENSMUSG00000126855 ENSMUST00000278619.1 ENSMUSG00000126855 (from geneSymbol) uc333gwo.1 uc333gwo.1 
ENSMUST00000278621.1 ENSMUSG00000126856 ENSMUST00000278621.1 ENSMUSG00000126856 (from geneSymbol) uc333gwq.1 uc333gwq.1 
ENSMUST00000278636.1 ENSMUSG00000126857 ENSMUST00000278636.1 ENSMUSG00000126857 (from geneSymbol) uc333gxf.1 uc333gxf.1 
ENSMUST00000278644.1 ENSMUSG00000126858 ENSMUST00000278644.1 ENSMUSG00000126858 (from geneSymbol) uc333gxn.1 uc333gxn.1 
ENSMUST00000278645.1 ENSMUSG00000126859 ENSMUST00000278645.1 ENSMUSG00000126859 (from geneSymbol) uc333gxo.1 uc333gxo.1 
ENSMUST00000278647.1 Gm30382 ENSMUST00000278647.1 Gm30382 (from geneSymbol) BC075654 uc333gxq.1 uc333gxq.1 
ENSMUST00000278662.1 Gm40123 ENSMUST00000278662.1 Gm40123 (from geneSymbol) BC092150 uc333gyf.1 uc333gyf.1 
ENSMUST00000278671.1 ENSMUSG00000126860 ENSMUST00000278671.1 ENSMUSG00000126860 (from geneSymbol) uc333gyo.1 uc333gyo.1 
ENSMUST00000278672.1 ENSMUSG00000126861 ENSMUST00000278672.1 ENSMUSG00000126861 (from geneSymbol) uc333gyp.1 uc333gyp.1 
ENSMUST00000278686.1 ENSMUSG00000126862 ENSMUST00000278686.1 ENSMUSG00000126862 (from geneSymbol) uc333gzd.1 uc333gzd.1 
ENSMUST00000278688.1 ENSMUSG00000126863 ENSMUST00000278688.1 ENSMUSG00000126863 (from geneSymbol) uc333gzf.1 uc333gzf.1 
ENSMUST00000278690.1 Gm32554 ENSMUST00000278690.1 Gm32554 (from geneSymbol) uc333gzh.1 uc333gzh.1 
ENSMUST00000278694.1 ENSMUSG00000126864 ENSMUST00000278694.1 ENSMUSG00000126864 (from geneSymbol) uc333gzl.1 uc333gzl.1 
ENSMUST00000278696.1 ENSMUSG00000126865 ENSMUST00000278696.1 ENSMUSG00000126865 (from geneSymbol) uc333gzn.1 uc333gzn.1 
ENSMUST00000278710.1 ENSMUSG00000126866 ENSMUST00000278710.1 ENSMUSG00000126866 (from geneSymbol) uc333hab.1 uc333hab.1 
ENSMUST00000278711.1 ENSMUSG00000126867 ENSMUST00000278711.1 ENSMUSG00000126867 (from geneSymbol) uc333hac.1 uc333hac.1 
ENSMUST00000278712.1 ENSMUSG00000126868 ENSMUST00000278712.1 ENSMUSG00000126868 (from geneSymbol) uc333had.1 uc333had.1 
ENSMUST00000278713.1 ENSMUSG00000126869 ENSMUST00000278713.1 ENSMUSG00000126869 (from geneSymbol) uc333hae.1 uc333hae.1 
ENSMUST00000278714.1 ENSMUSG00000126870 ENSMUST00000278714.1 ENSMUSG00000126870 (from geneSymbol) uc333haf.1 uc333haf.1 
ENSMUST00000278716.1 Gm28643 ENSMUST00000278716.1 Gm28643 (from geneSymbol) uc333hah.1 uc333hah.1 
ENSMUST00000278720.1 ENSMUSG00000126871 ENSMUST00000278720.1 ENSMUSG00000126871 (from geneSymbol) uc333hal.1 uc333hal.1 
ENSMUST00000278721.1 Gm47134 ENSMUST00000278721.1 Gm47134 (from geneSymbol) uc333ham.1 uc333ham.1 
ENSMUST00000278725.1 ENSMUSG00000126872 ENSMUST00000278725.1 ENSMUSG00000126872 (from geneSymbol) uc333haq.1 uc333haq.1 
ENSMUST00000278736.1 ENSMUSG00000126873 ENSMUST00000278736.1 ENSMUSG00000126873 (from geneSymbol) uc333hbb.1 uc333hbb.1 
ENSMUST00000278738.1 ENSMUSG00000126874 ENSMUST00000278738.1 ENSMUSG00000126874 (from geneSymbol) uc333hbd.1 uc333hbd.1 
ENSMUST00000278742.1 1700006J14Rik ENSMUST00000278742.1 1700006J14Rik (from geneSymbol) AK005678 uc333hbh.1 uc333hbh.1 
ENSMUST00000278757.1 ENSMUSG00000126875 ENSMUST00000278757.1 ENSMUSG00000126875 (from geneSymbol) uc333hbw.1 uc333hbw.1 
ENSMUST00000278758.1 ENSMUSG00000126876 ENSMUST00000278758.1 ENSMUSG00000126876 (from geneSymbol) uc333hbx.1 uc333hbx.1 
ENSMUST00000278759.1 Gm32727 ENSMUST00000278759.1 Gm32727 (from geneSymbol) uc333hby.1 uc333hby.1 
ENSMUST00000278767.1 ENSMUSG00000126877 ENSMUST00000278767.1 ENSMUSG00000126877 (from geneSymbol) uc333hcg.1 uc333hcg.1 
ENSMUST00000278769.1 ENSMUSG00000126878 ENSMUST00000278769.1 ENSMUSG00000126878 (from geneSymbol) uc333hci.1 uc333hci.1 
ENSMUST00000278778.1 ENSMUSG00000126879 ENSMUST00000278778.1 ENSMUSG00000126879 (from geneSymbol) uc333hcr.1 uc333hcr.1 
ENSMUST00000278779.1 ENSMUSG00000126880 ENSMUST00000278779.1 ENSMUSG00000126880 (from geneSymbol) uc333hcs.1 uc333hcs.1 
ENSMUST00000278781.1 ENSMUSG00000126881 ENSMUST00000278781.1 ENSMUSG00000126881 (from geneSymbol) uc333hct.1 uc333hct.1 
ENSMUST00000278782.1 ENSMUSG00000126882 ENSMUST00000278782.1 ENSMUSG00000126882 (from geneSymbol) uc333hcu.1 uc333hcu.1 
ENSMUST00000278784.1 ENSMUSG00000126883 ENSMUST00000278784.1 ENSMUSG00000126883 (from geneSymbol) uc333hcw.1 uc333hcw.1 
ENSMUST00000278786.1 ENSMUSG00000126884 ENSMUST00000278786.1 ENSMUSG00000126884 (from geneSymbol) uc333hcy.1 uc333hcy.1 
ENSMUST00000278790.1 ENSMUSG00000126885 ENSMUST00000278790.1 ENSMUSG00000126885 (from geneSymbol) uc333hdc.1 uc333hdc.1 
ENSMUST00000278792.1 ENSMUSG00000126886 ENSMUST00000278792.1 ENSMUSG00000126886 (from geneSymbol) uc333hde.1 uc333hde.1 
ENSMUST00000278809.1 ENSMUSG00000126887 ENSMUST00000278809.1 ENSMUSG00000126887 (from geneSymbol) uc333hdv.1 uc333hdv.1 
ENSMUST00000278812.1 ENSMUSG00000126888 ENSMUST00000278812.1 ENSMUSG00000126888 (from geneSymbol) uc333hdy.1 uc333hdy.1 
ENSMUST00000278813.1 ENSMUSG00000126889 ENSMUST00000278813.1 ENSMUSG00000126889 (from geneSymbol) uc333hdz.1 uc333hdz.1 
ENSMUST00000278816.1 BB187676 ENSMUST00000278816.1 BB187676 (from geneSymbol) uc333hec.1 uc333hec.1 
ENSMUST00000278819.1 ENSMUSG00000126891 ENSMUST00000278819.1 ENSMUSG00000126891 (from geneSymbol) uc333hee.1 uc333hee.1 
ENSMUST00000278820.1 ENSMUSG00000126892 ENSMUST00000278820.1 ENSMUSG00000126892 (from geneSymbol) uc333hef.1 uc333hef.1 
ENSMUST00000278826.1 4933406F09Rik ENSMUST00000278826.1 4933406F09Rik (from geneSymbol) AK016686 uc333hel.1 uc333hel.1 
ENSMUST00000278829.1 ENSMUSG00000126893 ENSMUST00000278829.1 ENSMUSG00000126893 (from geneSymbol) AK082860 uc333heo.1 uc333heo.1 
ENSMUST00000278831.1 ENSMUSG00000126895 ENSMUST00000278831.1 ENSMUSG00000126895 (from geneSymbol) uc333hep.1 uc333hep.1 
ENSMUST00000278834.1 Gm5149 ENSMUST00000278834.1 Gm5149 (from geneSymbol) AK132813 uc333her.1 uc333her.1 
ENSMUST00000278861.1 ENSMUSG00000126897 ENSMUST00000278861.1 ENSMUSG00000126897 (from geneSymbol) uc333hfs.1 uc333hfs.1 
ENSMUST00000278885.1 4930441H08Rik ENSMUST00000278885.1 4930441H08Rik (from geneSymbol) AK019606 uc333hgq.1 uc333hgq.1 
ENSMUST00000278895.1 ENSMUSG00000126898 ENSMUST00000278895.1 ENSMUSG00000126898 (from geneSymbol) uc333hgz.1 uc333hgz.1 
ENSMUST00000278899.1 ENSMUSG00000126899 ENSMUST00000278899.1 ENSMUSG00000126899 (from geneSymbol) uc333hhd.1 uc333hhd.1 
ENSMUST00000278900.1 ENSMUSG00000126900 ENSMUST00000278900.1 ENSMUSG00000126900 (from geneSymbol) uc333hhe.1 uc333hhe.1 
ENSMUST00000278904.1 ENSMUSG00000126901 ENSMUST00000278904.1 ENSMUSG00000126901 (from geneSymbol) uc333hhi.1 uc333hhi.1 
ENSMUST00000278905.1 ENSMUSG00000126902 ENSMUST00000278905.1 ENSMUSG00000126902 (from geneSymbol) uc333hhj.1 uc333hhj.1 
ENSMUST00000278906.1 ENSMUSG00000126903 ENSMUST00000278906.1 ENSMUSG00000126903 (from geneSymbol) uc333hhk.1 uc333hhk.1 
ENSMUST00000278907.1 1700026N04Rik ENSMUST00000278907.1 1700026N04Rik (from geneSymbol) AK006396 uc333hhl.1 uc333hhl.1 
ENSMUST00000278915.1 1700007J10Rik ENSMUST00000278915.1 1700007J10Rik (from geneSymbol) AK005722 uc333hht.1 uc333hht.1 
ENSMUST00000278927.1 Gm32540 ENSMUST00000278927.1 Gm32540 (from geneSymbol) uc333hie.1 uc333hie.1 
ENSMUST00000278936.1 ENSMUSG00000126904 ENSMUST00000278936.1 ENSMUSG00000126904 (from geneSymbol) uc333hin.1 uc333hin.1 
ENSMUST00000278937.1 ENSMUSG00000126905 ENSMUST00000278937.1 ENSMUSG00000126905 (from geneSymbol) uc333hio.1 uc333hio.1 
ENSMUST00000278940.1 ENSMUSG00000126906 ENSMUST00000278940.1 ENSMUSG00000126906 (from geneSymbol) uc333hir.1 uc333hir.1 
ENSMUST00000278943.1 ENSMUSG00000126907 ENSMUST00000278943.1 ENSMUSG00000126907 (from geneSymbol) uc333hiu.1 uc333hiu.1 
ENSMUST00000278959.1 ENSMUSG00000126908 ENSMUST00000278959.1 ENSMUSG00000126908 (from geneSymbol) AK041093 uc333hjk.1 uc333hjk.1 
ENSMUST00000278963.1 ENSMUSG00000126909 ENSMUST00000278963.1 ENSMUSG00000126909 (from geneSymbol) uc333hjn.1 uc333hjn.1 
ENSMUST00000278964.1 ENSMUSG00000126910 ENSMUST00000278964.1 ENSMUSG00000126910 (from geneSymbol) uc333hjo.1 uc333hjo.1 
ENSMUST00000278965.1 ENSMUSG00000126911 ENSMUST00000278965.1 ENSMUSG00000126911 (from geneSymbol) uc333hjp.1 uc333hjp.1 
ENSMUST00000278967.1 ENSMUSG00000126912 ENSMUST00000278967.1 ENSMUSG00000126912 (from geneSymbol) uc333hjr.1 uc333hjr.1 
ENSMUST00000278970.1 ENSMUSG00000126913 ENSMUST00000278970.1 ENSMUSG00000126913 (from geneSymbol) uc333hju.1 uc333hju.1 
ENSMUST00000278974.1 ENSMUSG00000126915 ENSMUST00000278974.1 ENSMUSG00000126915 (from geneSymbol) uc333hjx.1 uc333hjx.1 
ENSMUST00000278981.1 ENSMUSG00000126916 ENSMUST00000278981.1 ENSMUSG00000126916 (from geneSymbol) uc333hke.1 uc333hke.1 
ENSMUST00000278985.1 ENSMUSG00000126917 ENSMUST00000278985.1 ENSMUSG00000126917 (from geneSymbol) uc333hki.1 uc333hki.1 
ENSMUST00000278996.1 ENSMUSG00000126918 ENSMUST00000278996.1 ENSMUSG00000126918 (from geneSymbol) uc333hkt.1 uc333hkt.1 
ENSMUST00000278999.1 ENSMUSG00000126919 ENSMUST00000278999.1 ENSMUSG00000126919 (from geneSymbol) uc333hkw.1 uc333hkw.1 
ENSMUST00000279008.1 ENSMUSG00000126920 ENSMUST00000279008.1 ENSMUSG00000126920 (from geneSymbol) uc333hlf.1 uc333hlf.1 
ENSMUST00000279012.1 1700067G17Rik ENSMUST00000279012.1 1700067G17Rik (from geneSymbol) AK006914 uc333hlj.1 uc333hlj.1 
ENSMUST00000279020.1 ENSMUSG00000126921 ENSMUST00000279020.1 ENSMUSG00000126921 (from geneSymbol) uc333hlr.1 uc333hlr.1 
ENSMUST00000279021.1 ENSMUSG00000126922 ENSMUST00000279021.1 ENSMUSG00000126922 (from geneSymbol) uc333hls.1 uc333hls.1 
ENSMUST00000279022.1 ENSMUSG00000126923 ENSMUST00000279022.1 ENSMUSG00000126923 (from geneSymbol) uc333hlt.1 uc333hlt.1 
ENSMUST00000279038.1 Gm56697 ENSMUST00000279038.1 Gm56697 (from geneSymbol) uc333hmj.1 uc333hmj.1 
ENSMUST00000279046.1 ENSMUSG00000126924 ENSMUST00000279046.1 ENSMUSG00000126924 (from geneSymbol) uc333hmr.1 uc333hmr.1 
ENSMUST00000279047.1 ENSMUSG00000126925 ENSMUST00000279047.1 ENSMUSG00000126925 (from geneSymbol) uc333hms.1 uc333hms.1 
ENSMUST00000279049.1 ENSMUSG00000126926 ENSMUST00000279049.1 ENSMUSG00000126926 (from geneSymbol) uc333hmu.1 uc333hmu.1 
ENSMUST00000279051.1 ENSMUSG00000126927 ENSMUST00000279051.1 ENSMUSG00000126927 (from geneSymbol) AK134674 uc333hmw.1 uc333hmw.1 
ENSMUST00000279057.1 ENSMUSG00000126928 ENSMUST00000279057.1 ENSMUSG00000126928 (from geneSymbol) uc333hnc.1 uc333hnc.1 
ENSMUST00000279060.1 ENSMUSG00000126929 ENSMUST00000279060.1 ENSMUSG00000126929 (from geneSymbol) uc333hnf.1 uc333hnf.1 
ENSMUST00000279099.1 ENSMUSG00000126930 ENSMUST00000279099.1 ENSMUSG00000126930 (from geneSymbol) uc333hos.1 uc333hos.1 
ENSMUST00000279101.1 ENSMUSG00000126931 ENSMUST00000279101.1 ENSMUSG00000126931 (from geneSymbol) uc333hou.1 uc333hou.1 
ENSMUST00000279107.1 ENSMUSG00000126932 ENSMUST00000279107.1 ENSMUSG00000126932 (from geneSymbol) uc333hpa.1 uc333hpa.1 
ENSMUST00000279112.1 ENSMUSG00000126933 ENSMUST00000279112.1 ENSMUSG00000126933 (from geneSymbol) uc333hpf.1 uc333hpf.1 
ENSMUST00000279125.1 2610318M16Rik ENSMUST00000279125.1 2610318M16Rik (from geneSymbol) uc333hps.1 uc333hps.1 
ENSMUST00000279184.1 4930515B02Rik ENSMUST00000279184.1 4930515B02Rik (from geneSymbol) AK015793 uc333hrz.1 uc333hrz.1 
ENSMUST00000279198.1 ENSMUSG00000126934 ENSMUST00000279198.1 ENSMUSG00000126934 (from geneSymbol) uc333hsn.1 uc333hsn.1 
ENSMUST00000279208.1 ENSMUSG00000126935 ENSMUST00000279208.1 ENSMUSG00000126935 (from geneSymbol) uc333hsx.1 uc333hsx.1 
ENSMUST00000279209.1 Gm45274 ENSMUST00000279209.1 Gm45274 (from geneSymbol) uc333hsy.1 uc333hsy.1 
ENSMUST00000279210.1 ENSMUSG00000126936 ENSMUST00000279210.1 ENSMUSG00000126936 (from geneSymbol) FJ541091 uc333hsz.1 uc333hsz.1 
ENSMUST00000279213.1 ENSMUSG00000126937 ENSMUST00000279213.1 ENSMUSG00000126937 (from geneSymbol) uc333htc.1 uc333htc.1 
ENSMUST00000279214.1 ENSMUSG00000126938 ENSMUST00000279214.1 ENSMUSG00000126938 (from geneSymbol) uc333htd.1 uc333htd.1 
ENSMUST00000279219.1 ENSMUSG00000126939 ENSMUST00000279219.1 ENSMUSG00000126939 (from geneSymbol) uc333hti.1 uc333hti.1 
ENSMUST00000279223.1 ENSMUSG00000126940 ENSMUST00000279223.1 ENSMUSG00000126940 (from geneSymbol) uc333htm.1 uc333htm.1 
ENSMUST00000279226.1 ENSMUSG00000126941 ENSMUST00000279226.1 ENSMUSG00000126941 (from geneSymbol) uc333htp.1 uc333htp.1 
ENSMUST00000279229.1 4930546B01Rik ENSMUST00000279229.1 4930546B01Rik (from geneSymbol) AK016049 uc333hts.1 uc333hts.1 
ENSMUST00000279231.1 ENSMUSG00000126942 ENSMUST00000279231.1 ENSMUSG00000126942 (from geneSymbol) uc333htu.1 uc333htu.1 
ENSMUST00000279235.1 ENSMUSG00000126943 ENSMUST00000279235.1 ENSMUSG00000126943 (from geneSymbol) uc333hty.1 uc333hty.1 
ENSMUST00000279238.1 ENSMUSG00000126944 ENSMUST00000279238.1 ENSMUSG00000126944 (from geneSymbol) AK006729 uc333hub.1 uc333hub.1 
ENSMUST00000279240.1 ENSMUSG00000126945 ENSMUST00000279240.1 ENSMUSG00000126945 (from geneSymbol) uc333hud.1 uc333hud.1 
ENSMUST00000279241.1 Speer5-ps1 ENSMUST00000279241.1 Speer5-ps1 (from geneSymbol) AK005695 uc333hue.1 uc333hue.1 
ENSMUST00000279243.1 ENSMUSG00000126946 ENSMUST00000279243.1 ENSMUSG00000126946 (from geneSymbol) uc333hug.1 uc333hug.1 
ENSMUST00000279244.1 ENSMUSG00000126947 ENSMUST00000279244.1 ENSMUSG00000126947 (from geneSymbol) uc333huh.1 uc333huh.1 
ENSMUST00000279245.1 ENSMUSG00000126948 ENSMUST00000279245.1 ENSMUSG00000126948 (from geneSymbol) uc333hui.1 uc333hui.1 
ENSMUST00000279261.1 ENSMUSG00000126949 ENSMUST00000279261.1 ENSMUSG00000126949 (from geneSymbol) uc333huy.1 uc333huy.1 
ENSMUST00000279262.1 ENSMUSG00000126950 ENSMUST00000279262.1 ENSMUSG00000126950 (from geneSymbol) uc333huz.1 uc333huz.1 
ENSMUST00000279265.1 ENSMUSG00000126951 ENSMUST00000279265.1 ENSMUSG00000126951 (from geneSymbol) DQ694443 uc333hvb.1 uc333hvb.1 
ENSMUST00000279266.1 ENSMUSG00000126952 ENSMUST00000279266.1 ENSMUSG00000126952 (from geneSymbol) uc333hvc.1 uc333hvc.1 
ENSMUST00000279268.1 ENSMUSG00000126953 ENSMUST00000279268.1 ENSMUSG00000126953 (from geneSymbol) uc333hve.1 uc333hve.1 
ENSMUST00000279271.1 ENSMUSG00000126954 ENSMUST00000279271.1 ENSMUSG00000126954 (from geneSymbol) uc333hvh.1 uc333hvh.1 
ENSMUST00000279272.1 ENSMUSG00000126955 ENSMUST00000279272.1 ENSMUSG00000126955 (from geneSymbol) uc333hvi.1 uc333hvi.1 
ENSMUST00000279273.1 ENSMUSG00000126956 ENSMUST00000279273.1 ENSMUSG00000126956 (from geneSymbol) X96606 uc333hvj.1 uc333hvj.1 
ENSMUST00000279277.1 ENSMUSG00000126957 ENSMUST00000279277.1 ENSMUSG00000126957 (from geneSymbol) uc333hvn.1 uc333hvn.1 
ENSMUST00000279286.1 ENSMUSG00000126958 ENSMUST00000279286.1 ENSMUSG00000126958 (from geneSymbol) uc333hvw.1 uc333hvw.1 
ENSMUST00000279287.1 Gm31005 ENSMUST00000279287.1 Gm31005 (from geneSymbol) uc333hvx.1 uc333hvx.1 
ENSMUST00000279300.1 Gm26562 ENSMUST00000279300.1 Gm26562 (from geneSymbol) AK132624 uc333hwk.1 uc333hwk.1 
ENSMUST00000279342.1 ENSMUSG00000126959 ENSMUST00000279342.1 ENSMUSG00000126959 (from geneSymbol) uc333hya.1 uc333hya.1 
ENSMUST00000279365.1 ENSMUSG00000126960 ENSMUST00000279365.1 ENSMUSG00000126960 (from geneSymbol) uc333hyx.1 uc333hyx.1 
ENSMUST00000279366.1 ENSMUSG00000126961 ENSMUST00000279366.1 ENSMUSG00000126961 (from geneSymbol) uc333hyy.1 uc333hyy.1 
ENSMUST00000279367.1 ENSMUSG00000126962 ENSMUST00000279367.1 ENSMUSG00000126962 (from geneSymbol) uc333hyz.1 uc333hyz.1 
ENSMUST00000279369.1 ENSMUSG00000126963 ENSMUST00000279369.1 ENSMUSG00000126963 (from geneSymbol) uc333hzb.1 uc333hzb.1 
ENSMUST00000279370.1 ENSMUSG00000126964 ENSMUST00000279370.1 ENSMUSG00000126964 (from geneSymbol) uc333hzc.1 uc333hzc.1 
ENSMUST00000279373.1 ENSMUSG00000126965 ENSMUST00000279373.1 ENSMUSG00000126965 (from geneSymbol) uc333hzf.1 uc333hzf.1 
ENSMUST00000279375.1 Gm31881 ENSMUST00000279375.1 Gm31881 (from geneSymbol) uc333hzh.1 uc333hzh.1 
ENSMUST00000279380.1 ENSMUSG00000126966 ENSMUST00000279380.1 ENSMUSG00000126966 (from geneSymbol) uc333hzm.1 uc333hzm.1 
ENSMUST00000279383.1 ENSMUSG00000126967 ENSMUST00000279383.1 ENSMUSG00000126967 (from geneSymbol) uc333hzp.1 uc333hzp.1 
ENSMUST00000279384.1 ENSMUSG00000126968 ENSMUST00000279384.1 ENSMUSG00000126968 (from geneSymbol) uc333hzq.1 uc333hzq.1 
ENSMUST00000279385.1 ENSMUSG00000126969 ENSMUST00000279385.1 ENSMUSG00000126969 (from geneSymbol) uc333hzr.1 uc333hzr.1 
ENSMUST00000279387.1 1700041A01Rik ENSMUST00000279387.1 1700041A01Rik (from geneSymbol) AK006665 uc333hzt.1 uc333hzt.1 
ENSMUST00000279391.1 ENSMUSG00000126971 ENSMUST00000279391.1 ENSMUSG00000126971 (from geneSymbol) uc333hzx.1 uc333hzx.1 
ENSMUST00000279394.1 ENSMUSG00000126972 ENSMUST00000279394.1 ENSMUSG00000126972 (from geneSymbol) uc333iaa.1 uc333iaa.1 
ENSMUST00000279396.1 ENSMUSG00000126973 ENSMUST00000279396.1 ENSMUSG00000126973 (from geneSymbol) uc333iac.1 uc333iac.1 
ENSMUST00000279398.1 ENSMUSG00000126974 ENSMUST00000279398.1 ENSMUSG00000126974 (from geneSymbol) uc333iae.1 uc333iae.1 
ENSMUST00000279400.1 ENSMUSG00000126975 ENSMUST00000279400.1 ENSMUSG00000126975 (from geneSymbol) uc333iag.1 uc333iag.1 
ENSMUST00000279401.1 ENSMUSG00000126976 ENSMUST00000279401.1 ENSMUSG00000126976 (from geneSymbol) uc333iah.1 uc333iah.1 
ENSMUST00000279405.1 ENSMUSG00000126977 ENSMUST00000279405.1 ENSMUSG00000126977 (from geneSymbol) uc333ial.1 uc333ial.1 
ENSMUST00000279418.1 ENSMUSG00000126978 ENSMUST00000279418.1 ENSMUSG00000126978 (from geneSymbol) uc333iay.1 uc333iay.1 
ENSMUST00000279426.1 Gm6981 ENSMUST00000279426.1 Gm6981 (from geneSymbol) AK132984 uc333ibg.1 uc333ibg.1 
ENSMUST00000279485.1 ENSMUSG00000126980 ENSMUST00000279485.1 ENSMUSG00000126980 (from geneSymbol) uc333idn.1 uc333idn.1 
ENSMUST00000279487.1 ENSMUSG00000126981 ENSMUST00000279487.1 ENSMUSG00000126981 (from geneSymbol) uc333idp.1 uc333idp.1 
ENSMUST00000279493.1 Gm31013 ENSMUST00000279493.1 Gm31013 (from geneSymbol) uc333idv.1 uc333idv.1 
ENSMUST00000279510.1 ENSMUSG00000126982 ENSMUST00000279510.1 ENSMUSG00000126982 (from geneSymbol) uc333iem.1 uc333iem.1 
ENSMUST00000279511.1 ENSMUSG00000126983 ENSMUST00000279511.1 ENSMUSG00000126983 (from geneSymbol) uc333ien.1 uc333ien.1 
ENSMUST00000279512.1 ENSMUSG00000126984 ENSMUST00000279512.1 ENSMUSG00000126984 (from geneSymbol) uc333ieo.1 uc333ieo.1 
ENSMUST00000279513.1 ENSMUSG00000126985 ENSMUST00000279513.1 ENSMUSG00000126985 (from geneSymbol) uc333iep.1 uc333iep.1 
ENSMUST00000279514.1 Gm12259 ENSMUST00000279514.1 Gm12259 (from geneSymbol) uc333ieq.1 uc333ieq.1 
ENSMUST00000279515.1 ENSMUSG00000126986 ENSMUST00000279515.1 ENSMUSG00000126986 (from geneSymbol) uc333ier.1 uc333ier.1 
ENSMUST00000279516.1 ENSMUSG00000126987 ENSMUST00000279516.1 ENSMUSG00000126987 (from geneSymbol) uc333ies.1 uc333ies.1 
ENSMUST00000279518.1 ENSMUSG00000126988 ENSMUST00000279518.1 ENSMUSG00000126988 (from geneSymbol) uc333ieu.1 uc333ieu.1 
ENSMUST00000279519.1 ENSMUSG00000126989 ENSMUST00000279519.1 ENSMUSG00000126989 (from geneSymbol) uc333iev.1 uc333iev.1 
ENSMUST00000279521.1 ENSMUSG00000126990 ENSMUST00000279521.1 ENSMUSG00000126990 (from geneSymbol) uc333iex.1 uc333iex.1 
ENSMUST00000279522.1 ENSMUSG00000126991 ENSMUST00000279522.1 ENSMUSG00000126991 (from geneSymbol) uc333iey.1 uc333iey.1 
ENSMUST00000279552.1 ENSMUSG00000126992 ENSMUST00000279552.1 ENSMUSG00000126992 (from geneSymbol) uc333igc.1 uc333igc.1 
ENSMUST00000279553.1 ENSMUSG00000126993 ENSMUST00000279553.1 ENSMUSG00000126993 (from geneSymbol) uc333igd.1 uc333igd.1 
ENSMUST00000279557.1 ENSMUSG00000126994 ENSMUST00000279557.1 ENSMUSG00000126994 (from geneSymbol) uc333igh.1 uc333igh.1 
ENSMUST00000279559.1 ENSMUSG00000126995 ENSMUST00000279559.1 ENSMUSG00000126995 (from geneSymbol) uc333igj.1 uc333igj.1 
ENSMUST00000279560.1 ENSMUSG00000126996 ENSMUST00000279560.1 ENSMUSG00000126996 (from geneSymbol) uc333igk.1 uc333igk.1 
ENSMUST00000279561.1 Pla2g10os ENSMUST00000279561.1 Pla2g10os (from geneSymbol) AK007362 uc333igl.1 uc333igl.1 
ENSMUST00000279575.1 ENSMUSG00000126997 ENSMUST00000279575.1 ENSMUSG00000126997 (from geneSymbol) uc333igz.1 uc333igz.1 
ENSMUST00000279584.1 ENSMUSG00000126998 ENSMUST00000279584.1 ENSMUSG00000126998 (from geneSymbol) uc333ihi.1 uc333ihi.1 
ENSMUST00000279585.1 ENSMUSG00000126999 ENSMUST00000279585.1 ENSMUSG00000126999 (from geneSymbol) uc333ihj.1 uc333ihj.1 
ENSMUST00000279586.1 ENSMUSG00000127000 ENSMUST00000279586.1 ENSMUSG00000127000 (from geneSymbol) uc333ihk.1 uc333ihk.1 
ENSMUST00000279590.1 ENSMUSG00000127001 ENSMUST00000279590.1 ENSMUSG00000127001 (from geneSymbol) uc333iho.1 uc333iho.1 
ENSMUST00000279591.1 ENSMUSG00000127002 ENSMUST00000279591.1 ENSMUSG00000127002 (from geneSymbol) uc333ihp.1 uc333ihp.1 
ENSMUST00000279592.1 ENSMUSG00000127003 ENSMUST00000279592.1 ENSMUSG00000127003 (from geneSymbol) uc333ihq.1 uc333ihq.1 
ENSMUST00000279598.1 1700025H01Rik ENSMUST00000279598.1 1700025H01Rik (from geneSymbol) AK006338 uc333ihw.1 uc333ihw.1 
ENSMUST00000279607.1 ENSMUSG00000127004 ENSMUST00000279607.1 ENSMUSG00000127004 (from geneSymbol) AK029422 uc333iif.1 uc333iif.1 
ENSMUST00000279609.1 ENSMUSG00000127005 ENSMUST00000279609.1 ENSMUSG00000127005 (from geneSymbol) uc333iih.1 uc333iih.1 
ENSMUST00000279610.1 ENSMUSG00000127006 ENSMUST00000279610.1 ENSMUSG00000127006 (from geneSymbol) uc333iii.1 uc333iii.1 
ENSMUST00000279612.1 ENSMUSG00000127007 ENSMUST00000279612.1 ENSMUSG00000127007 (from geneSymbol) uc333iik.1 uc333iik.1 
ENSMUST00000279613.1 ENSMUSG00000127008 ENSMUST00000279613.1 ENSMUSG00000127008 (from geneSymbol) uc333iil.1 uc333iil.1 
ENSMUST00000279615.1 ENSMUSG00000127009 ENSMUST00000279615.1 ENSMUSG00000127009 (from geneSymbol) uc333iin.1 uc333iin.1 
ENSMUST00000279621.1 ENSMUSG00000127010 ENSMUST00000279621.1 ENSMUSG00000127010 (from geneSymbol) uc333iit.1 uc333iit.1 
ENSMUST00000279623.1 ENSMUSG00000127011 ENSMUST00000279623.1 ENSMUSG00000127011 (from geneSymbol) uc333iiv.1 uc333iiv.1 
ENSMUST00000279627.1 ENSMUSG00000127012 ENSMUST00000279627.1 ENSMUSG00000127012 (from geneSymbol) uc333iiz.1 uc333iiz.1 
ENSMUST00000279628.1 ENSMUSG00000127013 ENSMUST00000279628.1 ENSMUSG00000127013 (from geneSymbol) uc333ija.1 uc333ija.1 
ENSMUST00000279631.1 ENSMUSG00000127014 ENSMUST00000279631.1 ENSMUSG00000127014 (from geneSymbol) uc333ijd.1 uc333ijd.1 
ENSMUST00000279632.1 ENSMUSG00000127015 ENSMUST00000279632.1 ENSMUSG00000127015 (from geneSymbol) uc333ije.1 uc333ije.1 
ENSMUST00000279633.1 Tbx3os2 ENSMUST00000279633.1 Tbx3os2 (from geneSymbol) AK083542 uc333ijf.1 uc333ijf.1 
ENSMUST00000279645.1 ENSMUSG00000127016 ENSMUST00000279645.1 ENSMUSG00000127016 (from geneSymbol) uc333ijr.1 uc333ijr.1 
ENSMUST00000279652.1 Gm57087 ENSMUST00000279652.1 Gm57087 (from geneSymbol) uc333ijy.1 uc333ijy.1 
ENSMUST00000279653.1 ENSMUSG00000127017 ENSMUST00000279653.1 ENSMUSG00000127017 (from geneSymbol) uc333ijz.1 uc333ijz.1 
ENSMUST00000279657.1 ENSMUSG00000127018 ENSMUST00000279657.1 ENSMUSG00000127018 (from geneSymbol) AK131799 uc333ikd.1 uc333ikd.1 
ENSMUST00000279661.1 ENSMUSG00000127019 ENSMUST00000279661.1 ENSMUSG00000127019 (from geneSymbol) uc333ikh.1 uc333ikh.1 
ENSMUST00000279663.1 ENSMUSG00000127021 ENSMUST00000279663.1 ENSMUSG00000127021 (from geneSymbol) uc333iki.1 uc333iki.1 
ENSMUST00000279666.1 ENSMUSG00000127022 ENSMUST00000279666.1 ENSMUSG00000127022 (from geneSymbol) uc333ikj.1 uc333ikj.1 
ENSMUST00000279668.1 ENSMUSG00000127023 ENSMUST00000279668.1 ENSMUSG00000127023 (from geneSymbol) uc333ikl.1 uc333ikl.1 
ENSMUST00000279669.1 ENSMUSG00000127024 ENSMUST00000279669.1 ENSMUSG00000127024 (from geneSymbol) uc333ikm.1 uc333ikm.1 
ENSMUST00000279672.1 ENSMUSG00000127025 ENSMUST00000279672.1 ENSMUSG00000127025 (from geneSymbol) uc333iko.1 uc333iko.1 
ENSMUST00000279673.1 ENSMUSG00000127026 ENSMUST00000279673.1 ENSMUSG00000127026 (from geneSymbol) uc333ikp.1 uc333ikp.1 
ENSMUST00000279677.1 ENSMUSG00000127027 ENSMUST00000279677.1 ENSMUSG00000127027 (from geneSymbol) uc333ikr.1 uc333ikr.1 
ENSMUST00000279678.1 ENSMUSG00000127028 ENSMUST00000279678.1 ENSMUSG00000127028 (from geneSymbol) uc333iks.1 uc333iks.1 
ENSMUST00000279679.1 ENSMUSG00000127029 ENSMUST00000279679.1 ENSMUSG00000127029 (from geneSymbol) uc333ikt.1 uc333ikt.1 
ENSMUST00000279681.1 ENSMUSG00000127030 ENSMUST00000279681.1 ENSMUSG00000127030 (from geneSymbol) uc333ikv.1 uc333ikv.1 
ENSMUST00000279682.1 ENSMUSG00000127031 ENSMUST00000279682.1 ENSMUSG00000127031 (from geneSymbol) uc333ikw.1 uc333ikw.1 
ENSMUST00000279683.1 ENSMUSG00000127032 ENSMUST00000279683.1 ENSMUSG00000127032 (from geneSymbol) uc333ikx.1 uc333ikx.1 
ENSMUST00000279684.1 ENSMUSG00000127033 ENSMUST00000279684.1 ENSMUSG00000127033 (from geneSymbol) uc333iky.1 uc333iky.1 
ENSMUST00000279686.1 ENSMUSG00000127034 ENSMUST00000279686.1 ENSMUSG00000127034 (from geneSymbol) uc333ila.1 uc333ila.1 
ENSMUST00000279688.1 ENSMUSG00000127035 ENSMUST00000279688.1 ENSMUSG00000127035 (from geneSymbol) uc333ilc.1 uc333ilc.1 
ENSMUST00000279695.1 Gm44781 ENSMUST00000279695.1 Gm44781 (from geneSymbol) uc333ilj.1 uc333ilj.1 
ENSMUST00000279697.1 ENSMUSG00000127036 ENSMUST00000279697.1 ENSMUSG00000127036 (from geneSymbol) uc333ill.1 uc333ill.1 
ENSMUST00000279701.1 ENSMUSG00000127037 ENSMUST00000279701.1 ENSMUSG00000127037 (from geneSymbol) uc333ilp.1 uc333ilp.1 
ENSMUST00000279702.1 ENSMUSG00000127038 ENSMUST00000279702.1 ENSMUSG00000127038 (from geneSymbol) uc333ilq.1 uc333ilq.1 
ENSMUST00000279703.1 1700017M07Rik ENSMUST00000279703.1 1700017M07Rik (from geneSymbol) AK006073 uc333ilr.1 uc333ilr.1 
ENSMUST00000279757.1 ENSMUSG00000127039 ENSMUST00000279757.1 ENSMUSG00000127039 (from geneSymbol) uc333int.1 uc333int.1 
ENSMUST00000279759.1 ENSMUSG00000127040 ENSMUST00000279759.1 ENSMUSG00000127040 (from geneSymbol) uc333inv.1 uc333inv.1 
ENSMUST00000279760.1 ENSMUSG00000127041 ENSMUST00000279760.1 ENSMUSG00000127041 (from geneSymbol) uc333inw.1 uc333inw.1 
ENSMUST00000279761.1 ENSMUSG00000127042 ENSMUST00000279761.1 ENSMUSG00000127042 (from geneSymbol) uc333inx.1 uc333inx.1 
ENSMUST00000279763.1 ENSMUSG00000127043 ENSMUST00000279763.1 ENSMUSG00000127043 (from geneSymbol) uc333inz.1 uc333inz.1 
ENSMUST00000279771.1 ENSMUSG00000127044 ENSMUST00000279771.1 ENSMUSG00000127044 (from geneSymbol) uc333ioh.1 uc333ioh.1 
ENSMUST00000279773.1 ENSMUSG00000127045 ENSMUST00000279773.1 ENSMUSG00000127045 (from geneSymbol) uc333ioj.1 uc333ioj.1 
ENSMUST00000279775.1 ENSMUSG00000127046 ENSMUST00000279775.1 ENSMUSG00000127046 (from geneSymbol) uc333iol.1 uc333iol.1 
ENSMUST00000279785.1 Gm47438 ENSMUST00000279785.1 Gm47438 (from geneSymbol) uc333iov.1 uc333iov.1 
ENSMUST00000279800.1 ENSMUSG00000127047 ENSMUST00000279800.1 ENSMUSG00000127047 (from geneSymbol) uc333ipk.1 uc333ipk.1 
ENSMUST00000279801.1 ENSMUSG00000127048 ENSMUST00000279801.1 ENSMUSG00000127048 (from geneSymbol) uc333ipl.1 uc333ipl.1 
ENSMUST00000279803.1 ENSMUSG00000127049 ENSMUST00000279803.1 ENSMUSG00000127049 (from geneSymbol) uc333ipn.1 uc333ipn.1 
ENSMUST00000279805.1 ENSMUSG00000127050 ENSMUST00000279805.1 ENSMUSG00000127050 (from geneSymbol) uc333ipp.1 uc333ipp.1 
ENSMUST00000279806.1 ENSMUSG00000127051 ENSMUST00000279806.1 ENSMUSG00000127051 (from geneSymbol) uc333ipq.1 uc333ipq.1 
ENSMUST00000279819.1 Gm11753 ENSMUST00000279819.1 Gm11753 (from geneSymbol) KY467622 uc333iqd.1 uc333iqd.1 
ENSMUST00000279820.1 ENSMUSG00000127052 ENSMUST00000279820.1 ENSMUSG00000127052 (from geneSymbol) uc333iqe.1 uc333iqe.1 
ENSMUST00000279822.1 ENSMUSG00000127054 ENSMUST00000279822.1 ENSMUSG00000127054 (from geneSymbol) uc333iqf.1 uc333iqf.1 
ENSMUST00000279824.1 ENSMUSG00000127055 ENSMUST00000279824.1 ENSMUSG00000127055 (from geneSymbol) uc333iqh.1 uc333iqh.1 
ENSMUST00000279827.1 ENSMUSG00000127056 ENSMUST00000279827.1 ENSMUSG00000127056 (from geneSymbol) uc333iqk.1 uc333iqk.1 
ENSMUST00000279828.1 ENSMUSG00000127057 ENSMUST00000279828.1 ENSMUSG00000127057 (from geneSymbol) uc333iql.1 uc333iql.1 
ENSMUST00000279831.1 ENSMUSG00000127058 ENSMUST00000279831.1 ENSMUSG00000127058 (from geneSymbol) uc333iqo.1 uc333iqo.1 
ENSMUST00000279832.1 ENSMUSG00000127059 ENSMUST00000279832.1 ENSMUSG00000127059 (from geneSymbol) uc333iqp.1 uc333iqp.1 
ENSMUST00000279833.1 ENSMUSG00000127060 ENSMUST00000279833.1 ENSMUSG00000127060 (from geneSymbol) uc333iqq.1 uc333iqq.1 
ENSMUST00000279834.1 ENSMUSG00000127061 ENSMUST00000279834.1 ENSMUSG00000127061 (from geneSymbol) uc333iqr.1 uc333iqr.1 
ENSMUST00000279837.1 ENSMUSG00000127064 ENSMUST00000279837.1 ENSMUSG00000127064 (from geneSymbol) uc333iqs.1 uc333iqs.1 
ENSMUST00000279838.1 ENSMUSG00000127065 ENSMUST00000279838.1 ENSMUSG00000127065 (from geneSymbol) uc333iqt.1 uc333iqt.1 
ENSMUST00000279839.1 ENSMUSG00000127066 ENSMUST00000279839.1 ENSMUSG00000127066 (from geneSymbol) uc333iqu.1 uc333iqu.1 
ENSMUST00000279842.1 ENSMUSG00000127067 ENSMUST00000279842.1 ENSMUSG00000127067 (from geneSymbol) uc333iqx.1 uc333iqx.1 
ENSMUST00000279848.1 ENSMUSG00000127068 ENSMUST00000279848.1 ENSMUSG00000127068 (from geneSymbol) uc333ird.1 uc333ird.1 
ENSMUST00000279854.1 ENSMUSG00000127070 ENSMUST00000279854.1 ENSMUSG00000127070 (from geneSymbol) uc333iri.1 uc333iri.1 
ENSMUST00000279858.1 Gm16754 ENSMUST00000279858.1 Gm16754 (from geneSymbol) AK154190 uc333irm.1 uc333irm.1 
ENSMUST00000279869.1 ENSMUSG00000127071 ENSMUST00000279869.1 ENSMUSG00000127071 (from geneSymbol) uc333irx.1 uc333irx.1 
ENSMUST00000279870.1 ENSMUSG00000127072 ENSMUST00000279870.1 ENSMUSG00000127072 (from geneSymbol) uc333iry.1 uc333iry.1 
ENSMUST00000279871.1 ENSMUSG00000127073 ENSMUST00000279871.1 ENSMUSG00000127073 (from geneSymbol) uc333irz.1 uc333irz.1 
ENSMUST00000279873.1 ENSMUSG00000127074 ENSMUST00000279873.1 ENSMUSG00000127074 (from geneSymbol) uc333isb.1 uc333isb.1 
ENSMUST00000279874.1 ENSMUSG00000127075 ENSMUST00000279874.1 ENSMUSG00000127075 (from geneSymbol) uc333isc.1 uc333isc.1 
ENSMUST00000279875.1 ENSMUSG00000127076 ENSMUST00000279875.1 ENSMUSG00000127076 (from geneSymbol) uc333isd.1 uc333isd.1 
ENSMUST00000279886.1 ENSMUSG00000127077 ENSMUST00000279886.1 ENSMUSG00000127077 (from geneSymbol) uc333iso.1 uc333iso.1 
ENSMUST00000279887.1 ENSMUSG00000127078 ENSMUST00000279887.1 ENSMUSG00000127078 (from geneSymbol) uc333isp.1 uc333isp.1 
ENSMUST00000279890.1 ENSMUSG00000127079 ENSMUST00000279890.1 ENSMUSG00000127079 (from geneSymbol) uc333iss.1 uc333iss.1 
ENSMUST00000279911.1 Gm30411 ENSMUST00000279911.1 Gm30411 (from geneSymbol) uc333itn.1 uc333itn.1 
ENSMUST00000279925.1 ENSMUSG00000127080 ENSMUST00000279925.1 ENSMUSG00000127080 (from geneSymbol) uc333iub.1 uc333iub.1 
ENSMUST00000279926.1 ENSMUSG00000127081 ENSMUST00000279926.1 ENSMUSG00000127081 (from geneSymbol) uc333iuc.1 uc333iuc.1 
ENSMUST00000279929.1 ENSMUSG00000127082 ENSMUST00000279929.1 ENSMUSG00000127082 (from geneSymbol) uc333iuf.1 uc333iuf.1 
ENSMUST00000279931.1 ENSMUSG00000127083 ENSMUST00000279931.1 ENSMUSG00000127083 (from geneSymbol) uc333iuh.1 uc333iuh.1 
ENSMUST00000279932.1 ENSMUSG00000127084 ENSMUST00000279932.1 ENSMUSG00000127084 (from geneSymbol) uc333iui.1 uc333iui.1 
ENSMUST00000279937.1 ENSMUSG00000127085 ENSMUST00000279937.1 ENSMUSG00000127085 (from geneSymbol) uc333iun.1 uc333iun.1 
ENSMUST00000279938.1 ENSMUSG00000127086 ENSMUST00000279938.1 ENSMUSG00000127086 (from geneSymbol) uc333iuo.1 uc333iuo.1 
ENSMUST00000279939.1 ENSMUSG00000127087 ENSMUST00000279939.1 ENSMUSG00000127087 (from geneSymbol) uc333iup.1 uc333iup.1 
ENSMUST00000279941.1 ENSMUSG00000127088 ENSMUST00000279941.1 ENSMUSG00000127088 (from geneSymbol) uc333iur.1 uc333iur.1 
ENSMUST00000279946.1 2600006K01Rik ENSMUST00000279946.1 2600006K01Rik (from geneSymbol) uc333iuw.1 uc333iuw.1 
ENSMUST00000279949.1 ENSMUSG00000127089 ENSMUST00000279949.1 ENSMUSG00000127089 (from geneSymbol) uc333iuz.1 uc333iuz.1 
ENSMUST00000279950.1 ENSMUSG00000127090 ENSMUST00000279950.1 ENSMUSG00000127090 (from geneSymbol) uc333iva.1 uc333iva.1 
ENSMUST00000279951.1 ENSMUSG00000127091 ENSMUST00000279951.1 ENSMUSG00000127091 (from geneSymbol) uc333ivb.1 uc333ivb.1 
ENSMUST00000279952.1 ENSMUSG00000127092 ENSMUST00000279952.1 ENSMUSG00000127092 (from geneSymbol) LF200690 uc333ivc.1 uc333ivc.1 
ENSMUST00000279953.1 ENSMUSG00000127093 ENSMUST00000279953.1 ENSMUSG00000127093 (from geneSymbol) uc333ivd.1 uc333ivd.1 
ENSMUST00000279955.1 ENSMUSG00000127094 ENSMUST00000279955.1 ENSMUSG00000127094 (from geneSymbol) uc333ivf.1 uc333ivf.1 
ENSMUST00000279956.1 ENSMUSG00000127095 ENSMUST00000279956.1 ENSMUSG00000127095 (from geneSymbol) uc333ivg.1 uc333ivg.1 
ENSMUST00000279957.1 ENSMUSG00000127096 ENSMUST00000279957.1 ENSMUSG00000127096 (from geneSymbol) uc333ivh.1 uc333ivh.1 
ENSMUST00000279960.1 ENSMUSG00000127097 ENSMUST00000279960.1 ENSMUSG00000127097 (from geneSymbol) AK133793 uc333ivk.1 uc333ivk.1 
ENSMUST00000279963.1 1700025L06Rik ENSMUST00000279963.1 1700025L06Rik (from geneSymbol) AK006355 uc333ivn.1 uc333ivn.1 
ENSMUST00000279966.1 Gm38353 ENSMUST00000279966.1 Gm38353 (from geneSymbol) AK044425 uc333ivq.1 uc333ivq.1 
ENSMUST00000279982.1 ENSMUSG00000127098 ENSMUST00000279982.1 ENSMUSG00000127098 (from geneSymbol) uc333iwg.1 uc333iwg.1 
ENSMUST00000279983.1 ENSMUSG00000127099 ENSMUST00000279983.1 ENSMUSG00000127099 (from geneSymbol) uc333iwh.1 uc333iwh.1 
ENSMUST00000279985.1 5730419F03Rik ENSMUST00000279985.1 5730419F03Rik (from geneSymbol) AK017575 uc333iwj.1 uc333iwj.1 
ENSMUST00000279991.1 1700084D21Rik ENSMUST00000279991.1 1700084D21Rik (from geneSymbol) AK006989 uc333iwp.1 uc333iwp.1 
ENSMUST00000279998.1 ENSMUSG00000127100 ENSMUST00000279998.1 ENSMUSG00000127100 (from geneSymbol) uc333iww.1 uc333iww.1 
ENSMUST00000280001.1 4933402C06Rik ENSMUST00000280001.1 4933402C06Rik (from geneSymbol) AK016610 uc333iwz.1 uc333iwz.1 
ENSMUST00000280016.1 ENSMUSG00000127101 ENSMUST00000280016.1 ENSMUSG00000127101 (from geneSymbol) uc333ixo.1 uc333ixo.1 
ENSMUST00000280017.1 ENSMUSG00000127102 ENSMUST00000280017.1 ENSMUSG00000127102 (from geneSymbol) uc333ixp.1 uc333ixp.1 
ENSMUST00000280021.1 ENSMUSG00000127103 ENSMUST00000280021.1 ENSMUSG00000127103 (from geneSymbol) uc333ixt.1 uc333ixt.1 
ENSMUST00000280023.1 ENSMUSG00000127104 ENSMUST00000280023.1 ENSMUSG00000127104 (from geneSymbol) uc333ixv.1 uc333ixv.1 
ENSMUST00000280025.1 ENSMUSG00000127105 ENSMUST00000280025.1 ENSMUSG00000127105 (from geneSymbol) uc333ixx.1 uc333ixx.1 
ENSMUST00000280029.1 ENSMUSG00000127106 ENSMUST00000280029.1 ENSMUSG00000127106 (from geneSymbol) uc333iyb.1 uc333iyb.1 
ENSMUST00000280033.1 ENSMUSG00000127107 ENSMUST00000280033.1 ENSMUSG00000127107 (from geneSymbol) uc333iyf.1 uc333iyf.1 
ENSMUST00000280034.1 ENSMUSG00000127108 ENSMUST00000280034.1 ENSMUSG00000127108 (from geneSymbol) uc333iyg.1 uc333iyg.1 
ENSMUST00000280035.1 ENSMUSG00000127109 ENSMUST00000280035.1 ENSMUSG00000127109 (from geneSymbol) uc333iyh.1 uc333iyh.1 
ENSMUST00000280039.1 ENSMUSG00000127110 ENSMUST00000280039.1 ENSMUSG00000127110 (from geneSymbol) uc333iyl.1 uc333iyl.1 
ENSMUST00000280040.1 ENSMUSG00000127111 ENSMUST00000280040.1 ENSMUSG00000127111 (from geneSymbol) uc333iym.1 uc333iym.1 
ENSMUST00000280041.1 ENSMUSG00000127112 ENSMUST00000280041.1 ENSMUSG00000127112 (from geneSymbol) uc333iyn.1 uc333iyn.1 
ENSMUST00000280042.1 ENSMUSG00000127113 ENSMUST00000280042.1 ENSMUSG00000127113 (from geneSymbol) AK006494 uc333iyo.1 uc333iyo.1 
ENSMUST00000280043.1 ENSMUSG00000127114 ENSMUST00000280043.1 ENSMUSG00000127114 (from geneSymbol) uc333iyp.1 uc333iyp.1 
ENSMUST00000280044.1 ENSMUSG00000127115 ENSMUST00000280044.1 ENSMUSG00000127115 (from geneSymbol) uc333iyq.1 uc333iyq.1 
ENSMUST00000280045.1 ENSMUSG00000127116 ENSMUST00000280045.1 ENSMUSG00000127116 (from geneSymbol) uc333iyr.1 uc333iyr.1 
ENSMUST00000280046.1 ENSMUSG00000127117 ENSMUST00000280046.1 ENSMUSG00000127117 (from geneSymbol) BC100413 uc333iys.1 uc333iys.1 
ENSMUST00000280049.1 Lncppara ENSMUST00000280049.1 Lncppara (from geneSymbol) uc333iyv.1 uc333iyv.1 
ENSMUST00000280081.1 ENSMUSG00000127118 ENSMUST00000280081.1 ENSMUSG00000127118 (from geneSymbol) uc333jab.1 uc333jab.1 
ENSMUST00000280082.1 ENSMUSG00000127119 ENSMUST00000280082.1 ENSMUSG00000127119 (from geneSymbol) uc333jac.1 uc333jac.1 
ENSMUST00000280089.1 ENSMUSG00000127120 ENSMUST00000280089.1 ENSMUSG00000127120 (from geneSymbol) uc333jaj.1 uc333jaj.1 
ENSMUST00000280096.1 ENSMUSG00000127121 ENSMUST00000280096.1 ENSMUSG00000127121 (from geneSymbol) uc333jaq.1 uc333jaq.1 
ENSMUST00000280097.1 ENSMUSG00000127122 ENSMUST00000280097.1 ENSMUSG00000127122 (from geneSymbol) uc333jar.1 uc333jar.1 
ENSMUST00000280100.1 ENSMUSG00000127123 ENSMUST00000280100.1 ENSMUSG00000127123 (from geneSymbol) uc333jau.1 uc333jau.1 
ENSMUST00000280106.1 ENSMUSG00000127124 ENSMUST00000280106.1 ENSMUSG00000127124 (from geneSymbol) uc333jba.1 uc333jba.1 
ENSMUST00000280107.1 ENSMUSG00000127125 ENSMUST00000280107.1 ENSMUSG00000127125 (from geneSymbol) uc333jbb.1 uc333jbb.1 
ENSMUST00000280109.1 Gm30790 ENSMUST00000280109.1 Gm30790 (from geneSymbol) AK038693 uc333jbd.1 uc333jbd.1 
ENSMUST00000280126.1 ENSMUSG00000127126 ENSMUST00000280126.1 ENSMUSG00000127126 (from geneSymbol) uc333jbu.1 uc333jbu.1 
ENSMUST00000280128.1 Gm40418 ENSMUST00000280128.1 Gm40418 (from geneSymbol) uc333jbw.1 uc333jbw.1 
ENSMUST00000280131.1 ENSMUSG00000127127 ENSMUST00000280131.1 ENSMUSG00000127127 (from geneSymbol) uc333jbz.1 uc333jbz.1 
ENSMUST00000280132.1 ENSMUSG00000127128 ENSMUST00000280132.1 ENSMUSG00000127128 (from geneSymbol) uc333jca.1 uc333jca.1 
ENSMUST00000280133.1 ENSMUSG00000127129 ENSMUST00000280133.1 ENSMUSG00000127129 (from geneSymbol) uc333jcb.1 uc333jcb.1 
ENSMUST00000280134.1 ENSMUSG00000127130 ENSMUST00000280134.1 ENSMUSG00000127130 (from geneSymbol) uc333jcc.1 uc333jcc.1 
ENSMUST00000280140.1 ENSMUSG00000127131 ENSMUST00000280140.1 ENSMUSG00000127131 (from geneSymbol) uc333jci.1 uc333jci.1 
ENSMUST00000280142.1 ENSMUSG00000127132 ENSMUST00000280142.1 ENSMUSG00000127132 (from geneSymbol) uc333jck.1 uc333jck.1 
ENSMUST00000280143.1 BC039966 ENSMUST00000280143.1 BC039966 (from geneSymbol) BC022702 uc333jcl.1 uc333jcl.1 
ENSMUST00000280153.1 ENSMUSG00000127133 ENSMUST00000280153.1 ENSMUSG00000127133 (from geneSymbol) uc333jcv.1 uc333jcv.1 
ENSMUST00000280154.1 ENSMUSG00000127134 ENSMUST00000280154.1 ENSMUSG00000127134 (from geneSymbol) uc333jcw.1 uc333jcw.1 
ENSMUST00000280176.1 ENSMUSG00000127136 ENSMUST00000280176.1 ENSMUSG00000127136 (from geneSymbol) uc333jdh.1 uc333jdh.1 
ENSMUST00000280177.1 ENSMUSG00000127137 ENSMUST00000280177.1 ENSMUSG00000127137 (from geneSymbol) uc333jdi.1 uc333jdi.1 
ENSMUST00000280182.1 ENSMUSG00000127138 ENSMUST00000280182.1 ENSMUSG00000127138 (from geneSymbol) uc333jdn.1 uc333jdn.1 
ENSMUST00000280184.1 ENSMUSG00000127139 ENSMUST00000280184.1 ENSMUSG00000127139 (from geneSymbol) uc333jdp.1 uc333jdp.1 
ENSMUST00000280185.1 ENSMUSG00000127140 ENSMUST00000280185.1 ENSMUSG00000127140 (from geneSymbol) uc333jdq.1 uc333jdq.1 
ENSMUST00000280187.1 4930592A05Rik ENSMUST00000280187.1 4930592A05Rik (from geneSymbol) AK016384 uc333jds.1 uc333jds.1 
ENSMUST00000280191.1 ENSMUSG00000127141 ENSMUST00000280191.1 ENSMUSG00000127141 (from geneSymbol) uc333jdw.1 uc333jdw.1 
ENSMUST00000280192.1 Gm15323 ENSMUST00000280192.1 Gm15323 (from geneSymbol) uc333jdx.1 uc333jdx.1 
ENSMUST00000280205.1 ENSMUSG00000127142 ENSMUST00000280205.1 ENSMUSG00000127142 (from geneSymbol) uc333jek.1 uc333jek.1 
ENSMUST00000280206.1 ENSMUSG00000127143 ENSMUST00000280206.1 ENSMUSG00000127143 (from geneSymbol) uc333jel.1 uc333jel.1 
ENSMUST00000280207.1 ENSMUSG00000127144 ENSMUST00000280207.1 ENSMUSG00000127144 (from geneSymbol) uc333jem.1 uc333jem.1 
ENSMUST00000280208.1 ENSMUSG00000127145 ENSMUST00000280208.1 ENSMUSG00000127145 (from geneSymbol) uc333jen.1 uc333jen.1 
ENSMUST00000280228.1 ENSMUSG00000127146 ENSMUST00000280228.1 ENSMUSG00000127146 (from geneSymbol) uc333jfh.1 uc333jfh.1 
ENSMUST00000280229.1 ENSMUSG00000127147 ENSMUST00000280229.1 ENSMUSG00000127147 (from geneSymbol) uc333jfi.1 uc333jfi.1 
ENSMUST00000280239.1 ENSMUSG00000127148 ENSMUST00000280239.1 ENSMUSG00000127148 (from geneSymbol) uc333jfs.1 uc333jfs.1 
ENSMUST00000280241.1 ENSMUSG00000127149 ENSMUST00000280241.1 ENSMUSG00000127149 (from geneSymbol) uc333jfu.1 uc333jfu.1 
ENSMUST00000280242.1 ENSMUSG00000127150 ENSMUST00000280242.1 ENSMUSG00000127150 (from geneSymbol) uc333jfv.1 uc333jfv.1 
ENSMUST00000280243.1 ENSMUSG00000127151 ENSMUST00000280243.1 ENSMUSG00000127151 (from geneSymbol) uc333jfw.1 uc333jfw.1 
ENSMUST00000280245.1 ENSMUSG00000127152 ENSMUST00000280245.1 ENSMUSG00000127152 (from geneSymbol) uc333jfy.1 uc333jfy.1 
ENSMUST00000280259.1 ENSMUSG00000127153 ENSMUST00000280259.1 ENSMUSG00000127153 (from geneSymbol) uc333jgm.1 uc333jgm.1 
ENSMUST00000280260.1 ENSMUSG00000127154 ENSMUST00000280260.1 ENSMUSG00000127154 (from geneSymbol) uc333jgn.1 uc333jgn.1 
ENSMUST00000280261.1 ENSMUSG00000127155 ENSMUST00000280261.1 ENSMUSG00000127155 (from geneSymbol) uc333jgo.1 uc333jgo.1 
ENSMUST00000280267.1 ENSMUSG00000127156 ENSMUST00000280267.1 ENSMUSG00000127156 (from geneSymbol) uc333jgu.1 uc333jgu.1 
ENSMUST00000280270.1 ENSMUSG00000127157 ENSMUST00000280270.1 ENSMUSG00000127157 (from geneSymbol) uc333jgx.1 uc333jgx.1 
ENSMUST00000280273.1 ENSMUSG00000127158 ENSMUST00000280273.1 ENSMUSG00000127158 (from geneSymbol) uc333jha.1 uc333jha.1 
ENSMUST00000280274.1 Gm31992 ENSMUST00000280274.1 Gm31992 (from geneSymbol) uc333jhb.1 uc333jhb.1 
ENSMUST00000280285.1 ENSMUSG00000127159 ENSMUST00000280285.1 ENSMUSG00000127159 (from geneSymbol) uc333jhm.1 uc333jhm.1 
ENSMUST00000280287.1 ENSMUSG00000127160 ENSMUST00000280287.1 ENSMUSG00000127160 (from geneSymbol) uc333jho.1 uc333jho.1 
ENSMUST00000280288.1 ENSMUSG00000127161 ENSMUST00000280288.1 ENSMUSG00000127161 (from geneSymbol) uc333jhp.1 uc333jhp.1 
ENSMUST00000280289.1 ENSMUSG00000127162 ENSMUST00000280289.1 ENSMUSG00000127162 (from geneSymbol) uc333jhq.1 uc333jhq.1 
ENSMUST00000280292.1 ENSMUSG00000127163 ENSMUST00000280292.1 ENSMUSG00000127163 (from geneSymbol) uc333jht.1 uc333jht.1 
ENSMUST00000280293.1 ENSMUSG00000127164 ENSMUST00000280293.1 ENSMUSG00000127164 (from geneSymbol) uc333jhu.1 uc333jhu.1 
ENSMUST00000280299.1 ENSMUSG00000127165 ENSMUST00000280299.1 ENSMUSG00000127165 (from geneSymbol) uc333jhz.1 uc333jhz.1 
ENSMUST00000280300.1 Gm56981 ENSMUST00000280300.1 Gm56981 (from geneSymbol) uc333jia.1 uc333jia.1 
ENSMUST00000280304.1 ENSMUSG00000127166 ENSMUST00000280304.1 ENSMUSG00000127166 (from geneSymbol) uc333jie.1 uc333jie.1 
ENSMUST00000280308.1 ENSMUSG00000127167 ENSMUST00000280308.1 ENSMUSG00000127167 (from geneSymbol) uc333jii.1 uc333jii.1 
ENSMUST00000280311.1 D330037F02Rik ENSMUST00000280311.1 D330037F02Rik (from geneSymbol) AK084740 uc333jil.1 uc333jil.1 
ENSMUST00000280319.1 ENSMUSG00000127168 ENSMUST00000280319.1 ENSMUSG00000127168 (from geneSymbol) uc333jit.1 uc333jit.1 
ENSMUST00000280325.1 ENSMUSG00000127169 ENSMUST00000280325.1 ENSMUSG00000127169 (from geneSymbol) uc333jiz.1 uc333jiz.1 
ENSMUST00000280326.1 ENSMUSG00000127170 ENSMUST00000280326.1 ENSMUSG00000127170 (from geneSymbol) uc333jja.1 uc333jja.1 
ENSMUST00000280329.1 ENSMUSG00000127171 ENSMUST00000280329.1 ENSMUSG00000127171 (from geneSymbol) uc333jjd.1 uc333jjd.1 
ENSMUST00000280331.1 ENSMUSG00000127172 ENSMUST00000280331.1 ENSMUSG00000127172 (from geneSymbol) uc333jjf.1 uc333jjf.1 
ENSMUST00000280333.1 ENSMUSG00000127173 ENSMUST00000280333.1 ENSMUSG00000127173 (from geneSymbol) uc333jjh.1 uc333jjh.1 
ENSMUST00000280334.1 ENSMUSG00000127174 ENSMUST00000280334.1 ENSMUSG00000127174 (from geneSymbol) uc333jji.1 uc333jji.1 
ENSMUST00000280336.1 ENSMUSG00000127175 ENSMUST00000280336.1 ENSMUSG00000127175 (from geneSymbol) uc333jjk.1 uc333jjk.1 
ENSMUST00000280343.1 ENSMUSG00000127176 ENSMUST00000280343.1 ENSMUSG00000127176 (from geneSymbol) uc333jjq.1 uc333jjq.1 
ENSMUST00000280345.1 ENSMUSG00000127177 ENSMUST00000280345.1 ENSMUSG00000127177 (from geneSymbol) uc333jjr.1 uc333jjr.1 
ENSMUST00000280348.1 ENSMUSG00000127178 ENSMUST00000280348.1 ENSMUSG00000127178 (from geneSymbol) uc333jju.1 uc333jju.1 
ENSMUST00000280352.1 ENSMUSG00000127179 ENSMUST00000280352.1 ENSMUSG00000127179 (from geneSymbol) uc333jjy.1 uc333jjy.1 
ENSMUST00000280354.1 Gm48665 ENSMUST00000280354.1 Gm48665 (from geneSymbol) uc333jka.1 uc333jka.1 
ENSMUST00000280361.1 Gm16008 ENSMUST00000280361.1 Gm16008 (from geneSymbol) KY468034 uc333jkh.1 uc333jkh.1 
ENSMUST00000280385.1 ENSMUSG00000127180 ENSMUST00000280385.1 ENSMUSG00000127180 (from geneSymbol) uc333jlc.1 uc333jlc.1 
ENSMUST00000280387.1 ENSMUSG00000127181 ENSMUST00000280387.1 ENSMUSG00000127181 (from geneSymbol) uc333jle.1 uc333jle.1 
ENSMUST00000280389.1 ENSMUSG00000127182 ENSMUST00000280389.1 ENSMUSG00000127182 (from geneSymbol) uc333jlg.1 uc333jlg.1 
ENSMUST00000280390.1 ENSMUSG00000127183 ENSMUST00000280390.1 ENSMUSG00000127183 (from geneSymbol) uc333jlh.1 uc333jlh.1 
ENSMUST00000280393.1 ENSMUSG00000127184 ENSMUST00000280393.1 ENSMUSG00000127184 (from geneSymbol) uc333jlk.1 uc333jlk.1 
ENSMUST00000280394.1 ENSMUSG00000127185 ENSMUST00000280394.1 ENSMUSG00000127185 (from geneSymbol) uc333jll.1 uc333jll.1 
ENSMUST00000280395.1 ENSMUSG00000127186 ENSMUST00000280395.1 ENSMUSG00000127186 (from geneSymbol) uc333jlm.1 uc333jlm.1 
ENSMUST00000280396.1 ENSMUSG00000127187 ENSMUST00000280396.1 ENSMUSG00000127187 (from geneSymbol) uc333jln.1 uc333jln.1 
ENSMUST00000280398.1 ENSMUSG00000127189 ENSMUST00000280398.1 ENSMUSG00000127189 (from geneSymbol) uc333jlo.1 uc333jlo.1 
ENSMUST00000280405.1 ENSMUSG00000127190 ENSMUST00000280405.1 ENSMUSG00000127190 (from geneSymbol) uc333jlv.1 uc333jlv.1 
ENSMUST00000280409.1 ENSMUSG00000127191 ENSMUST00000280409.1 ENSMUSG00000127191 (from geneSymbol) uc333jlz.1 uc333jlz.1 
ENSMUST00000280411.1 ENSMUSG00000121308 ENSMUST00000280411.1 ENSMUSG00000121308 (from geneSymbol) AK131849 uc333jmb.1 uc333jmb.1 
ENSMUST00000280422.1 ENSMUSG00000127192 ENSMUST00000280422.1 ENSMUSG00000127192 (from geneSymbol) uc333jml.1 uc333jml.1 
ENSMUST00000280426.1 ENSMUSG00000127193 ENSMUST00000280426.1 ENSMUSG00000127193 (from geneSymbol) LF203822 uc333jmp.1 uc333jmp.1 
ENSMUST00000280427.1 ENSMUSG00000127194 ENSMUST00000280427.1 ENSMUSG00000127194 (from geneSymbol) uc333jmq.1 uc333jmq.1 
ENSMUST00000280428.1 ENSMUSG00000127195 ENSMUST00000280428.1 ENSMUSG00000127195 (from geneSymbol) uc333jmr.1 uc333jmr.1 
ENSMUST00000280429.1 ENSMUSG00000127196 ENSMUST00000280429.1 ENSMUSG00000127196 (from geneSymbol) uc333jms.1 uc333jms.1 
ENSMUST00000280430.1 ENSMUSG00000127197 ENSMUST00000280430.1 ENSMUSG00000127197 (from geneSymbol) uc333jmt.1 uc333jmt.1 
ENSMUST00000280434.1 ENSMUSG00000127199 ENSMUST00000280434.1 ENSMUSG00000127199 (from geneSymbol) uc333jmw.1 uc333jmw.1 
ENSMUST00000280436.1 ENSMUSG00000127200 ENSMUST00000280436.1 ENSMUSG00000127200 (from geneSymbol) uc333jmy.1 uc333jmy.1 
ENSMUST00000280437.1 ENSMUSG00000127201 ENSMUST00000280437.1 ENSMUSG00000127201 (from geneSymbol) uc333jmz.1 uc333jmz.1 
ENSMUST00000280438.1 Gm39157 ENSMUST00000280438.1 Gm39157 (from geneSymbol) uc333jna.1 uc333jna.1 
ENSMUST00000280442.1 ENSMUSG00000127202 ENSMUST00000280442.1 ENSMUSG00000127202 (from geneSymbol) uc333jne.1 uc333jne.1 
ENSMUST00000280446.1 ENSMUSG00000127203 ENSMUST00000280446.1 ENSMUSG00000127203 (from geneSymbol) uc333jni.1 uc333jni.1 
ENSMUST00000280447.1 ENSMUSG00000127204 ENSMUST00000280447.1 ENSMUSG00000127204 (from geneSymbol) uc333jnj.1 uc333jnj.1 
ENSMUST00000280449.1 ENSMUSG00000127205 ENSMUST00000280449.1 ENSMUSG00000127205 (from geneSymbol) uc333jnl.1 uc333jnl.1 
ENSMUST00000280450.1 ENSMUSG00000127206 ENSMUST00000280450.1 ENSMUSG00000127206 (from geneSymbol) uc333jnm.1 uc333jnm.1 
ENSMUST00000280451.1 Gm43569 ENSMUST00000280451.1 Gm43569 (from geneSymbol) uc333jnn.1 uc333jnn.1 
ENSMUST00000280453.1 ENSMUSG00000127207 ENSMUST00000280453.1 ENSMUSG00000127207 (from geneSymbol) uc333jnp.1 uc333jnp.1 
ENSMUST00000280454.1 ENSMUSG00000127208 ENSMUST00000280454.1 ENSMUSG00000127208 (from geneSymbol) uc333jnq.1 uc333jnq.1 
ENSMUST00000280456.1 4933417E11Rik ENSMUST00000280456.1 4933417E11Rik (from geneSymbol) AK016843 uc333jns.1 uc333jns.1 
ENSMUST00000280484.1 ENSMUSG00000127209 ENSMUST00000280484.1 ENSMUSG00000127209 (from geneSymbol) uc333jou.1 uc333jou.1 
ENSMUST00000280485.1 ENSMUSG00000127210 ENSMUST00000280485.1 ENSMUSG00000127210 (from geneSymbol) uc333jov.1 uc333jov.1 
ENSMUST00000280488.1 ENSMUSG00000127211 ENSMUST00000280488.1 ENSMUSG00000127211 (from geneSymbol) uc333joy.1 uc333joy.1 
ENSMUST00000280491.1 ENSMUSG00000127212 ENSMUST00000280491.1 ENSMUSG00000127212 (from geneSymbol) uc333jpb.1 uc333jpb.1 
ENSMUST00000280496.1 ENSMUSG00000127213 ENSMUST00000280496.1 ENSMUSG00000127213 (from geneSymbol) uc333jpg.1 uc333jpg.1 
ENSMUST00000280498.1 ENSMUSG00000127214 ENSMUST00000280498.1 ENSMUSG00000127214 (from geneSymbol) uc333jpi.1 uc333jpi.1 
ENSMUST00000280499.1 ENSMUSG00000127215 ENSMUST00000280499.1 ENSMUSG00000127215 (from geneSymbol) uc333jpj.1 uc333jpj.1 
ENSMUST00000280500.1 ENSMUSG00000127216 ENSMUST00000280500.1 ENSMUSG00000127216 (from geneSymbol) BC049688 uc333jpk.1 uc333jpk.1 
ENSMUST00000280502.1 Gm28881 ENSMUST00000280502.1 Gm28881 (from geneSymbol) uc333jpm.1 uc333jpm.1 
ENSMUST00000280507.1 ENSMUSG00000127217 ENSMUST00000280507.1 ENSMUSG00000127217 (from geneSymbol) uc333jpr.1 uc333jpr.1 
ENSMUST00000280508.1 ENSMUSG00000127218 ENSMUST00000280508.1 ENSMUSG00000127218 (from geneSymbol) uc333jps.1 uc333jps.1 
ENSMUST00000280513.1 ENSMUSG00000127219 ENSMUST00000280513.1 ENSMUSG00000127219 (from geneSymbol) uc333jpx.1 uc333jpx.1 
ENSMUST00000280518.1 ENSMUSG00000127221 ENSMUST00000280518.1 ENSMUSG00000127221 (from geneSymbol) uc333jqb.1 uc333jqb.1 
ENSMUST00000280520.1 ENSMUSG00000127222 ENSMUST00000280520.1 ENSMUSG00000127222 (from geneSymbol) uc333jqd.1 uc333jqd.1 
ENSMUST00000280525.1 ENSMUSG00000127223 ENSMUST00000280525.1 ENSMUSG00000127223 (from geneSymbol) uc333jqi.1 uc333jqi.1 
ENSMUST00000280529.1 ENSMUSG00000127225 ENSMUST00000280529.1 ENSMUSG00000127225 (from geneSymbol) uc333jql.1 uc333jql.1 
ENSMUST00000280530.1 ENSMUSG00000127226 ENSMUST00000280530.1 ENSMUSG00000127226 (from geneSymbol) uc333jqm.1 uc333jqm.1 
ENSMUST00000280539.1 Gm32492 ENSMUST00000280539.1 Gm32492 (from geneSymbol) uc333jqv.1 uc333jqv.1 
ENSMUST00000280550.1 ENSMUSG00000127227 ENSMUST00000280550.1 ENSMUSG00000127227 (from geneSymbol) uc333jrg.1 uc333jrg.1 
ENSMUST00000280551.1 ENSMUSG00000127228 ENSMUST00000280551.1 ENSMUSG00000127228 (from geneSymbol) uc333jrh.1 uc333jrh.1 
ENSMUST00000280552.1 ENSMUSG00000127229 ENSMUST00000280552.1 ENSMUSG00000127229 (from geneSymbol) uc333jri.1 uc333jri.1 
ENSMUST00000280554.1 ENSMUSG00000127230 ENSMUST00000280554.1 ENSMUSG00000127230 (from geneSymbol) uc333jrk.1 uc333jrk.1 
ENSMUST00000280556.1 ENSMUSG00000127232 ENSMUST00000280556.1 ENSMUSG00000127232 (from geneSymbol) uc333jrl.1 uc333jrl.1 
ENSMUST00000280558.1 ENSMUSG00000127233 ENSMUST00000280558.1 ENSMUSG00000127233 (from geneSymbol) uc333jrn.1 uc333jrn.1 
ENSMUST00000280560.1 Gm16445 ENSMUST00000280560.1 Gm16445 (from geneSymbol) uc333jrp.1 uc333jrp.1 
ENSMUST00000280561.1 ENSMUSG00000127235 ENSMUST00000280561.1 ENSMUSG00000127235 (from geneSymbol) AB345102 uc333jrq.1 uc333jrq.1 
ENSMUST00000280562.1 ENSMUSG00000127236 ENSMUST00000280562.1 ENSMUSG00000127236 (from geneSymbol) uc333jrr.1 uc333jrr.1 
ENSMUST00000280566.1 ENSMUSG00000127237 ENSMUST00000280566.1 ENSMUSG00000127237 (from geneSymbol) uc333jru.1 uc333jru.1 
ENSMUST00000280573.1 ENSMUSG00000127238 ENSMUST00000280573.1 ENSMUSG00000127238 (from geneSymbol) uc333jsb.1 uc333jsb.1 
ENSMUST00000280582.1 ENSMUSG00000127239 ENSMUST00000280582.1 ENSMUSG00000127239 (from geneSymbol) uc333jsk.1 uc333jsk.1 
ENSMUST00000280599.1 Gm56898 ENSMUST00000280599.1 Gm56898 (from geneSymbol) uc333jtb.1 uc333jtb.1 
ENSMUST00000280601.1 ENSMUSG00000127240 ENSMUST00000280601.1 ENSMUSG00000127240 (from geneSymbol) uc333jtd.1 uc333jtd.1 
ENSMUST00000280602.1 Gm57377 ENSMUST00000280602.1 Gm57377 (from geneSymbol) uc333jte.1 uc333jte.1 
ENSMUST00000280608.1 Gm43568 ENSMUST00000280608.1 Gm43568 (from geneSymbol) AK158781 uc333jtk.1 uc333jtk.1 
ENSMUST00000280616.1 ENSMUSG00000127241 ENSMUST00000280616.1 ENSMUSG00000127241 (from geneSymbol) uc333jts.1 uc333jts.1 
ENSMUST00000280618.1 ENSMUSG00000127242 ENSMUST00000280618.1 ENSMUSG00000127242 (from geneSymbol) uc333jtu.1 uc333jtu.1 
ENSMUST00000280621.1 ENSMUSG00000127243 ENSMUST00000280621.1 ENSMUSG00000127243 (from geneSymbol) uc333jtx.1 uc333jtx.1 
ENSMUST00000280624.1 ENSMUSG00000127244 ENSMUST00000280624.1 ENSMUSG00000127244 (from geneSymbol) uc333jua.1 uc333jua.1 
ENSMUST00000280630.1 ENSMUSG00000127245 ENSMUST00000280630.1 ENSMUSG00000127245 (from geneSymbol) uc333jug.1 uc333jug.1 
ENSMUST00000280634.1 4930556G22Rik ENSMUST00000280634.1 4930556G22Rik (from geneSymbol) AK019769 uc333juk.1 uc333juk.1 
ENSMUST00000280639.1 ENSMUSG00000127246 ENSMUST00000280639.1 ENSMUSG00000127246 (from geneSymbol) uc333jup.1 uc333jup.1 
ENSMUST00000280643.1 ENSMUSG00000127247 ENSMUST00000280643.1 ENSMUSG00000127247 (from geneSymbol) uc333jut.1 uc333jut.1 
ENSMUST00000280644.1 ENSMUSG00000127248 ENSMUST00000280644.1 ENSMUSG00000127248 (from geneSymbol) uc333juu.1 uc333juu.1 
ENSMUST00000280645.1 ENSMUSG00000127249 ENSMUST00000280645.1 ENSMUSG00000127249 (from geneSymbol) uc333juv.1 uc333juv.1 
ENSMUST00000280647.1 ENSMUSG00000127250 ENSMUST00000280647.1 ENSMUSG00000127250 (from geneSymbol) uc333jux.1 uc333jux.1 
ENSMUST00000280651.1 ENSMUSG00000127251 ENSMUST00000280651.1 ENSMUSG00000127251 (from geneSymbol) AK152291 uc333jvb.1 uc333jvb.1 
ENSMUST00000280658.1 Gm36757 ENSMUST00000280658.1 Gm36757 (from geneSymbol) AK039743 uc333jvi.1 uc333jvi.1 
ENSMUST00000280674.1 ENSMUSG00000127253 ENSMUST00000280674.1 ENSMUSG00000127253 (from geneSymbol) uc333jvx.1 uc333jvx.1 
ENSMUST00000280675.1 Gm57434 ENSMUST00000280675.1 Gm57434 (from geneSymbol) uc333jvy.1 uc333jvy.1 
ENSMUST00000280676.1 ENSMUSG00000127254 ENSMUST00000280676.1 ENSMUSG00000127254 (from geneSymbol) uc333jvz.1 uc333jvz.1 
ENSMUST00000280678.1 Gm44659 ENSMUST00000280678.1 Gm44659 (from geneSymbol) uc333jwb.1 uc333jwb.1 
ENSMUST00000280682.1 ENSMUSG00000127255 ENSMUST00000280682.1 ENSMUSG00000127255 (from geneSymbol) uc333jwe.1 uc333jwe.1 
ENSMUST00000280688.1 ENSMUSG00000127256 ENSMUST00000280688.1 ENSMUSG00000127256 (from geneSymbol) uc333jwk.1 uc333jwk.1 
ENSMUST00000280691.1 ENSMUSG00000127257 ENSMUST00000280691.1 ENSMUSG00000127257 (from geneSymbol) uc333jwn.1 uc333jwn.1 
ENSMUST00000280711.1 ENSMUSG00000127258 ENSMUST00000280711.1 ENSMUSG00000127258 (from geneSymbol) uc333jxh.1 uc333jxh.1 
ENSMUST00000280714.1 Gm49957 ENSMUST00000280714.1 Gm49957 (from geneSymbol) BC063063 uc333jxk.1 uc333jxk.1 
ENSMUST00000280724.1 ENSMUSG00000127259 ENSMUST00000280724.1 ENSMUSG00000127259 (from geneSymbol) uc333jxu.1 uc333jxu.1 
ENSMUST00000280725.1 Gm32764 ENSMUST00000280725.1 Gm32764 (from geneSymbol) uc333jxv.1 uc333jxv.1 
ENSMUST00000280728.1 Gm12602 ENSMUST00000280728.1 Gm12602 (from geneSymbol) AK144841 uc333jxy.1 uc333jxy.1 
ENSMUST00000280742.1 ENSMUSG00000127260 ENSMUST00000280742.1 ENSMUSG00000127260 (from geneSymbol) uc333jym.1 uc333jym.1 
ENSMUST00000280748.1 ENSMUSG00000127261 ENSMUST00000280748.1 ENSMUSG00000127261 (from geneSymbol) uc333jys.1 uc333jys.1 
ENSMUST00000280751.1 ENSMUSG00000127262 ENSMUST00000280751.1 ENSMUSG00000127262 (from geneSymbol) uc333jyv.1 uc333jyv.1 
ENSMUST00000280758.1 ENSMUSG00000127263 ENSMUST00000280758.1 ENSMUSG00000127263 (from geneSymbol) uc333jzc.1 uc333jzc.1 
ENSMUST00000280759.1 ENSMUSG00000127264 ENSMUST00000280759.1 ENSMUSG00000127264 (from geneSymbol) uc333jzd.1 uc333jzd.1 
ENSMUST00000280760.1 ENSMUSG00000127265 ENSMUST00000280760.1 ENSMUSG00000127265 (from geneSymbol) uc333jze.1 uc333jze.1 
ENSMUST00000280764.1 ENSMUSG00000127266 ENSMUST00000280764.1 ENSMUSG00000127266 (from geneSymbol) uc333jzi.1 uc333jzi.1 
ENSMUST00000280769.1 ENSMUSG00000127267 ENSMUST00000280769.1 ENSMUSG00000127267 (from geneSymbol) uc333jzn.1 uc333jzn.1 
ENSMUST00000280770.1 ENSMUSG00000127268 ENSMUST00000280770.1 ENSMUSG00000127268 (from geneSymbol) uc333jzo.1 uc333jzo.1 
ENSMUST00000280771.1 ENSMUSG00000127269 ENSMUST00000280771.1 ENSMUSG00000127269 (from geneSymbol) uc333jzp.1 uc333jzp.1 
ENSMUST00000280772.1 ENSMUSG00000127270 ENSMUST00000280772.1 ENSMUSG00000127270 (from geneSymbol) uc333jzq.1 uc333jzq.1 
ENSMUST00000280775.1 ENSMUSG00000127271 ENSMUST00000280775.1 ENSMUSG00000127271 (from geneSymbol) uc333jzs.1 uc333jzs.1 
ENSMUST00000280779.1 ENSMUSG00000127272 ENSMUST00000280779.1 ENSMUSG00000127272 (from geneSymbol) uc333jzw.1 uc333jzw.1 
ENSMUST00000280783.1 ENSMUSG00000127273 ENSMUST00000280783.1 ENSMUSG00000127273 (from geneSymbol) uc333kaa.1 uc333kaa.1 
ENSMUST00000280785.1 ENSMUSG00000127275 ENSMUST00000280785.1 ENSMUSG00000127275 (from geneSymbol) uc333kab.1 uc333kab.1 
ENSMUST00000280791.1 ENSMUSG00000127276 ENSMUST00000280791.1 ENSMUSG00000127276 (from geneSymbol) uc333kah.1 uc333kah.1 
ENSMUST00000280792.1 ENSMUSG00000127277 ENSMUST00000280792.1 ENSMUSG00000127277 (from geneSymbol) uc333kai.1 uc333kai.1 
ENSMUST00000280793.1 ENSMUSG00000127278 ENSMUST00000280793.1 ENSMUSG00000127278 (from geneSymbol) uc333kaj.1 uc333kaj.1 
ENSMUST00000280813.1 ENSMUSG00000127279 ENSMUST00000280813.1 ENSMUSG00000127279 (from geneSymbol) uc333kbd.1 uc333kbd.1 
ENSMUST00000280815.1 ENSMUSG00000127280 ENSMUST00000280815.1 ENSMUSG00000127280 (from geneSymbol) uc333kbf.1 uc333kbf.1 
ENSMUST00000280819.1 ENSMUSG00000127281 ENSMUST00000280819.1 ENSMUSG00000127281 (from geneSymbol) AK135002 uc333kbj.1 uc333kbj.1 
ENSMUST00000280850.1 ENSMUSG00000127282 ENSMUST00000280850.1 ENSMUSG00000127282 (from geneSymbol) uc333kco.1 uc333kco.1 
ENSMUST00000280851.1 ENSMUSG00000127283 ENSMUST00000280851.1 ENSMUSG00000127283 (from geneSymbol) uc333kcp.1 uc333kcp.1 
ENSMUST00000280852.1 Gm57012 ENSMUST00000280852.1 Gm57012 (from geneSymbol) uc333kcq.1 uc333kcq.1 
ENSMUST00000280856.1 ENSMUSG00000127284 ENSMUST00000280856.1 ENSMUSG00000127284 (from geneSymbol) uc333kcu.1 uc333kcu.1 
ENSMUST00000280858.1 ENSMUSG00000127285 ENSMUST00000280858.1 ENSMUSG00000127285 (from geneSymbol) uc333kcw.1 uc333kcw.1 
ENSMUST00000280859.1 ENSMUSG00000127286 ENSMUST00000280859.1 ENSMUSG00000127286 (from geneSymbol) uc333kcx.1 uc333kcx.1 
ENSMUST00000280862.1 ENSMUSG00000127287 ENSMUST00000280862.1 ENSMUSG00000127287 (from geneSymbol) uc333kda.1 uc333kda.1 
ENSMUST00000280863.1 ENSMUSG00000127288 ENSMUST00000280863.1 ENSMUSG00000127288 (from geneSymbol) uc333kdb.1 uc333kdb.1 
ENSMUST00000280864.1 ENSMUSG00000127289 ENSMUST00000280864.1 ENSMUSG00000127289 (from geneSymbol) uc333kdc.1 uc333kdc.1 
ENSMUST00000280865.1 ENSMUSG00000127290 ENSMUST00000280865.1 ENSMUSG00000127290 (from geneSymbol) uc333kdd.1 uc333kdd.1 
ENSMUST00000280866.1 ENSMUSG00000127291 ENSMUST00000280866.1 ENSMUSG00000127291 (from geneSymbol) uc333kde.1 uc333kde.1 
ENSMUST00000280873.1 ENSMUSG00000127292 ENSMUST00000280873.1 ENSMUSG00000127292 (from geneSymbol) uc333kdl.1 uc333kdl.1 
ENSMUST00000280878.1 ENSMUSG00000127293 ENSMUST00000280878.1 ENSMUSG00000127293 (from geneSymbol) uc333kdq.1 uc333kdq.1 
ENSMUST00000280880.1 ENSMUSG00000127294 ENSMUST00000280880.1 ENSMUSG00000127294 (from geneSymbol) uc333kds.1 uc333kds.1 
ENSMUST00000280884.1 ENSMUSG00000127295 ENSMUST00000280884.1 ENSMUSG00000127295 (from geneSymbol) uc333kdw.1 uc333kdw.1 
ENSMUST00000280888.1 ENSMUSG00000127296 ENSMUST00000280888.1 ENSMUSG00000127296 (from geneSymbol) uc333kea.1 uc333kea.1 
ENSMUST00000280889.1 ENSMUSG00000127297 ENSMUST00000280889.1 ENSMUSG00000127297 (from geneSymbol) uc333keb.1 uc333keb.1 
ENSMUST00000280894.1 Gm30439 ENSMUST00000280894.1 Gm30439 (from geneSymbol) uc333keg.1 uc333keg.1 
ENSMUST00000280938.1 ENSMUSG00000127298 ENSMUST00000280938.1 ENSMUSG00000127298 (from geneSymbol) uc333kfy.1 uc333kfy.1 
ENSMUST00000280942.1 ENSMUSG00000127299 ENSMUST00000280942.1 ENSMUSG00000127299 (from geneSymbol) uc333kgc.1 uc333kgc.1 
ENSMUST00000280943.1 C030029H02Rik ENSMUST00000280943.1 C030029H02Rik (from geneSymbol) AK034027 uc333kgd.1 uc333kgd.1 
ENSMUST00000280946.1 ENSMUSG00000127300 ENSMUST00000280946.1 ENSMUSG00000127300 (from geneSymbol) uc333kgg.1 uc333kgg.1 
ENSMUST00000280947.1 6530413G14Rik ENSMUST00000280947.1 6530413G14Rik (from geneSymbol) AK016276 uc333kgh.1 uc333kgh.1 
ENSMUST00000280950.1 ENSMUSG00000127301 ENSMUST00000280950.1 ENSMUSG00000127301 (from geneSymbol) uc333kgk.1 uc333kgk.1 
ENSMUST00000280953.1 ENSMUSG00000127302 ENSMUST00000280953.1 ENSMUSG00000127302 (from geneSymbol) uc333kgn.1 uc333kgn.1 
ENSMUST00000280954.1 Gm32441 ENSMUST00000280954.1 Gm32441 (from geneSymbol) AK131795 uc333kgo.1 uc333kgo.1 
ENSMUST00000280960.1 ENSMUSG00000127303 ENSMUST00000280960.1 ENSMUSG00000127303 (from geneSymbol) uc333kgu.1 uc333kgu.1 
ENSMUST00000280961.1 ENSMUSG00000127304 ENSMUST00000280961.1 ENSMUSG00000127304 (from geneSymbol) uc333kgv.1 uc333kgv.1 
ENSMUST00000280963.1 ENSMUSG00000127305 ENSMUST00000280963.1 ENSMUSG00000127305 (from geneSymbol) uc333kgx.1 uc333kgx.1 
ENSMUST00000280967.1 ENSMUSG00000127306 ENSMUST00000280967.1 ENSMUSG00000127306 (from geneSymbol) uc333khb.1 uc333khb.1 
ENSMUST00000280968.1 ENSMUSG00000127307 ENSMUST00000280968.1 ENSMUSG00000127307 (from geneSymbol) uc333khc.1 uc333khc.1 
ENSMUST00000280974.1 Gm32652 ENSMUST00000280974.1 Gm32652 (from geneSymbol) uc333khi.1 uc333khi.1 
ENSMUST00000281012.1 Gm34150 ENSMUST00000281012.1 Gm34150 (from geneSymbol) uc333kiu.1 uc333kiu.1 
ENSMUST00000281036.1 ENSMUSG00000127308 ENSMUST00000281036.1 ENSMUSG00000127308 (from geneSymbol) uc333kjs.1 uc333kjs.1 
ENSMUST00000281052.1 Gm56847 ENSMUST00000281052.1 Gm56847 (from geneSymbol) NR_190332 uc333kjt.1 uc333kjt.1 
ENSMUST00000281068.1 ENSMUSG00000144212 ENSMUST00000281068.1 ENSMUSG00000144212 (from geneSymbol) BC086761 uc333kkj.1 uc333kkj.1 
ENSMUST00000281149.1 1700108F19Rik ENSMUST00000281149.1 1700108F19Rik (from geneSymbol) AK007133 uc333knm.1 uc333knm.1 
ENSMUST00000281220.1 ENSMUSG00000127310 ENSMUST00000281220.1 ENSMUSG00000127310 (from geneSymbol) uc333kqf.1 uc333kqf.1 
ENSMUST00000281229.1 Gm22219 ENSMUST00000281229.1 Gm22219 (from geneSymbol) uc333kqo.1 uc333kqo.1 
ENSMUST00000281247.1 ENSMUSG00000127311 ENSMUST00000281247.1 ENSMUSG00000127311 (from geneSymbol) uc333krg.1 uc333krg.1 
ENSMUST00000281250.1 ENSMUSG00000127312 ENSMUST00000281250.1 ENSMUSG00000127312 (from geneSymbol) uc333krj.1 uc333krj.1 
ENSMUST00000281260.1 Gm47157 ENSMUST00000281260.1 Gm47157 (from geneSymbol) uc333krt.1 uc333krt.1 
ENSMUST00000281269.1 ENSMUSG00000127313 ENSMUST00000281269.1 ENSMUSG00000127313 (from geneSymbol) uc333ksc.1 uc333ksc.1 
ENSMUST00000281271.1 ENSMUSG00000127314 ENSMUST00000281271.1 ENSMUSG00000127314 (from geneSymbol) uc333kse.1 uc333kse.1 
ENSMUST00000281273.1 ENSMUSG00000127315 ENSMUST00000281273.1 ENSMUSG00000127315 (from geneSymbol) uc333ksg.1 uc333ksg.1 
ENSMUST00000281276.1 ENSMUSG00000127316 ENSMUST00000281276.1 ENSMUSG00000127316 (from geneSymbol) uc333ksj.1 uc333ksj.1 
ENSMUST00000281282.1 ENSMUSG00000127317 ENSMUST00000281282.1 ENSMUSG00000127317 (from geneSymbol) uc333ksp.1 uc333ksp.1 
ENSMUST00000281287.1 ENSMUSG00000127318 ENSMUST00000281287.1 ENSMUSG00000127318 (from geneSymbol) uc333ksu.1 uc333ksu.1 
ENSMUST00000281288.1 ENSMUSG00000127319 ENSMUST00000281288.1 ENSMUSG00000127319 (from geneSymbol) uc333ksv.1 uc333ksv.1 
ENSMUST00000281293.1 5033406O09Rik ENSMUST00000281293.1 5033406O09Rik (from geneSymbol) AK020272 uc333kta.1 uc333kta.1 
ENSMUST00000281304.1 ENSMUSG00000127320 ENSMUST00000281304.1 ENSMUSG00000127320 (from geneSymbol) uc333ktl.1 uc333ktl.1 
ENSMUST00000281306.1 ENSMUSG00000127321 ENSMUST00000281306.1 ENSMUSG00000127321 (from geneSymbol) uc333ktn.1 uc333ktn.1 
ENSMUST00000281307.1 ENSMUSG00000127322 ENSMUST00000281307.1 ENSMUSG00000127322 (from geneSymbol) uc333kto.1 uc333kto.1 
ENSMUST00000281309.1 ENSMUSG00000127323 ENSMUST00000281309.1 ENSMUSG00000127323 (from geneSymbol) uc333ktq.1 uc333ktq.1 
ENSMUST00000281310.1 ENSMUSG00000127324 ENSMUST00000281310.1 ENSMUSG00000127324 (from geneSymbol) LF195777 uc333ktr.1 uc333ktr.1 
ENSMUST00000281314.1 ENSMUSG00000127325 ENSMUST00000281314.1 ENSMUSG00000127325 (from geneSymbol) uc333ktv.1 uc333ktv.1 
ENSMUST00000281322.1 ENSMUSG00000127326 ENSMUST00000281322.1 ENSMUSG00000127326 (from geneSymbol) uc333kud.1 uc333kud.1 
ENSMUST00000281379.1 ENSMUSG00000127327 ENSMUST00000281379.1 ENSMUSG00000127327 (from geneSymbol) uc333kwi.1 uc333kwi.1 
ENSMUST00000281381.1 4930543N07Rik ENSMUST00000281381.1 4930543N07Rik (from geneSymbol) AK016032 uc333kwk.1 uc333kwk.1 
ENSMUST00000281394.1 ENSMUSG00000127328 ENSMUST00000281394.1 ENSMUSG00000127328 (from geneSymbol) uc333kwx.1 uc333kwx.1 
ENSMUST00000281401.1 Igf1os ENSMUST00000281401.1 Igf1os (from geneSymbol) AK051435 uc333kxd.1 uc333kxd.1 
ENSMUST00000281429.1 ENSMUSG00000127329 ENSMUST00000281429.1 ENSMUSG00000127329 (from geneSymbol) uc333kyf.1 uc333kyf.1 
ENSMUST00000281430.1 ENSMUSG00000127330 ENSMUST00000281430.1 ENSMUSG00000127330 (from geneSymbol) uc333kyg.1 uc333kyg.1 
ENSMUST00000281434.1 ENSMUSG00000127331 ENSMUST00000281434.1 ENSMUSG00000127331 (from geneSymbol) uc333kyk.1 uc333kyk.1 
ENSMUST00000281435.1 ENSMUSG00000127332 ENSMUST00000281435.1 ENSMUSG00000127332 (from geneSymbol) uc333kyl.1 uc333kyl.1 
ENSMUST00000281438.1 ENSMUSG00000127333 ENSMUST00000281438.1 ENSMUSG00000127333 (from geneSymbol) uc333kyo.1 uc333kyo.1 
ENSMUST00000281439.1 ENSMUSG00000127334 ENSMUST00000281439.1 ENSMUSG00000127334 (from geneSymbol) uc333kyp.1 uc333kyp.1 
ENSMUST00000281441.1 ENSMUSG00000127335 ENSMUST00000281441.1 ENSMUSG00000127335 (from geneSymbol) uc333kyr.1 uc333kyr.1 
ENSMUST00000281449.1 ENSMUSG00000127336 ENSMUST00000281449.1 ENSMUSG00000127336 (from geneSymbol) uc333kyz.1 uc333kyz.1 
ENSMUST00000281461.1 ENSMUSG00000127337 ENSMUST00000281461.1 ENSMUSG00000127337 (from geneSymbol) uc333kzl.1 uc333kzl.1 
ENSMUST00000281462.1 ENSMUSG00000127338 ENSMUST00000281462.1 ENSMUSG00000127338 (from geneSymbol) uc333kzm.1 uc333kzm.1 
ENSMUST00000281464.1 ENSMUSG00000127339 ENSMUST00000281464.1 ENSMUSG00000127339 (from geneSymbol) uc333kzo.1 uc333kzo.1 
ENSMUST00000281468.1 ENSMUSG00000127340 ENSMUST00000281468.1 ENSMUSG00000127340 (from geneSymbol) uc333kzs.1 uc333kzs.1 
ENSMUST00000281470.1 ENSMUSG00000127341 ENSMUST00000281470.1 ENSMUSG00000127341 (from geneSymbol) uc333kzu.1 uc333kzu.1 
ENSMUST00000281478.1 Gm56975 ENSMUST00000281478.1 Gm56975 (from geneSymbol) uc333lac.1 uc333lac.1 
ENSMUST00000281479.1 ENSMUSG00000127342 ENSMUST00000281479.1 ENSMUSG00000127342 (from geneSymbol) uc333lad.1 uc333lad.1 
ENSMUST00000281487.1 ENSMUSG00000127343 ENSMUST00000281487.1 ENSMUSG00000127343 (from geneSymbol) uc333lal.1 uc333lal.1 
ENSMUST00000281493.1 ENSMUSG00000127344 ENSMUST00000281493.1 ENSMUSG00000127344 (from geneSymbol) uc333lar.1 uc333lar.1 
ENSMUST00000281497.1 ENSMUSG00000127345 ENSMUST00000281497.1 ENSMUSG00000127345 (from geneSymbol) uc333lav.1 uc333lav.1 
ENSMUST00000281510.1 Gm33936 ENSMUST00000281510.1 Gm33936 (from geneSymbol) uc333lbi.1 uc333lbi.1 
ENSMUST00000281569.1 Gm30190 ENSMUST00000281569.1 Gm30190 (from geneSymbol) uc333ldp.1 uc333ldp.1 
ENSMUST00000281577.1 ENSMUSG00000127346 ENSMUST00000281577.1 ENSMUSG00000127346 (from geneSymbol) uc333ldx.1 uc333ldx.1 
ENSMUST00000281606.1 ENSMUSG00000127347 ENSMUST00000281606.1 ENSMUSG00000127347 (from geneSymbol) uc333lfa.1 uc333lfa.1 
ENSMUST00000281615.1 ENSMUSG00000127348 ENSMUST00000281615.1 ENSMUSG00000127348 (from geneSymbol) AK140398 uc333lfj.1 uc333lfj.1 
ENSMUST00000281619.1 Gm34632 ENSMUST00000281619.1 Gm34632 (from geneSymbol) uc333lfn.1 uc333lfn.1 
ENSMUST00000281694.1 Gm33201 ENSMUST00000281694.1 Gm33201 (from geneSymbol) uc333lik.1 uc333lik.1 
ENSMUST00000281699.1 ENSMUSG00000127349 ENSMUST00000281699.1 ENSMUSG00000127349 (from geneSymbol) uc333lip.1 uc333lip.1 
ENSMUST00000281703.1 ENSMUSG00000127350 ENSMUST00000281703.1 ENSMUSG00000127350 (from geneSymbol) uc333lit.1 uc333lit.1 
ENSMUST00000281707.1 ENSMUSG00000127351 ENSMUST00000281707.1 ENSMUSG00000127351 (from geneSymbol) uc333lix.1 uc333lix.1 
ENSMUST00000281709.1 ENSMUSG00000127352 ENSMUST00000281709.1 ENSMUSG00000127352 (from geneSymbol) uc333liz.1 uc333liz.1 
ENSMUST00000281714.1 ENSMUSG00000127353 ENSMUST00000281714.1 ENSMUSG00000127353 (from geneSymbol) uc333lje.1 uc333lje.1 
ENSMUST00000281715.1 ENSMUSG00000127354 ENSMUST00000281715.1 ENSMUSG00000127354 (from geneSymbol) uc333ljf.1 uc333ljf.1 
ENSMUST00000281718.1 ENSMUSG00000127355 ENSMUST00000281718.1 ENSMUSG00000127355 (from geneSymbol) uc333lji.1 uc333lji.1 
ENSMUST00000281719.1 ENSMUSG00000127356 ENSMUST00000281719.1 ENSMUSG00000127356 (from geneSymbol) uc333ljj.1 uc333ljj.1 
ENSMUST00000281720.1 ENSMUSG00000127357 ENSMUST00000281720.1 ENSMUSG00000127357 (from geneSymbol) uc333ljk.1 uc333ljk.1 
ENSMUST00000281724.1 ENSMUSG00000127358 ENSMUST00000281724.1 ENSMUSG00000127358 (from geneSymbol) uc333ljo.1 uc333ljo.1 
ENSMUST00000281726.1 ENSMUSG00000121384 ENSMUST00000281726.1 ENSMUSG00000121384 (from geneSymbol) AK045648 uc333ljp.1 uc333ljp.1 
ENSMUST00000281735.1 ENSMUSG00000127359 ENSMUST00000281735.1 ENSMUSG00000127359 (from geneSymbol) uc333ljy.1 uc333ljy.1 
ENSMUST00000281741.1 ENSMUSG00000127360 ENSMUST00000281741.1 ENSMUSG00000127360 (from geneSymbol) uc333lke.1 uc333lke.1 
ENSMUST00000281742.1 ENSMUSG00000127361 ENSMUST00000281742.1 ENSMUSG00000127361 (from geneSymbol) uc333lkf.1 uc333lkf.1 
ENSMUST00000281759.1 ENSMUSG00000127362 ENSMUST00000281759.1 ENSMUSG00000127362 (from geneSymbol) uc333lkw.1 uc333lkw.1 
ENSMUST00000281762.1 Gm13322 ENSMUST00000281762.1 Gm13322 (from geneSymbol) uc333lkz.1 uc333lkz.1 
ENSMUST00000281770.1 ENSMUSG00000127363 ENSMUST00000281770.1 ENSMUSG00000127363 (from geneSymbol) uc333llh.1 uc333llh.1 
ENSMUST00000281771.1 ENSMUSG00000127364 ENSMUST00000281771.1 ENSMUSG00000127364 (from geneSymbol) uc333lli.1 uc333lli.1 
ENSMUST00000281781.1 ENSMUSG00000127365 ENSMUST00000281781.1 ENSMUSG00000127365 (from geneSymbol) uc333lls.1 uc333lls.1 
ENSMUST00000281782.1 ENSMUSG00000127366 ENSMUST00000281782.1 ENSMUSG00000127366 (from geneSymbol) uc333llt.1 uc333llt.1 
ENSMUST00000281784.1 ENSMUSG00000127367 ENSMUST00000281784.1 ENSMUSG00000127367 (from geneSymbol) uc333llv.1 uc333llv.1 
ENSMUST00000281786.1 ENSMUSG00000127368 ENSMUST00000281786.1 ENSMUSG00000127368 (from geneSymbol) uc333llx.1 uc333llx.1 
ENSMUST00000281787.1 ENSMUSG00000127369 ENSMUST00000281787.1 ENSMUSG00000127369 (from geneSymbol) uc333lly.1 uc333lly.1 
ENSMUST00000281790.1 Gm50413 ENSMUST00000281790.1 Gm50413 (from geneSymbol) uc333lmb.1 uc333lmb.1 
ENSMUST00000281791.1 ENSMUSG00000127370 ENSMUST00000281791.1 ENSMUSG00000127370 (from geneSymbol) uc333lmc.1 uc333lmc.1 
ENSMUST00000281792.1 ENSMUSG00000127371 ENSMUST00000281792.1 ENSMUSG00000127371 (from geneSymbol) uc333lmd.1 uc333lmd.1 
ENSMUST00000281793.1 Gm45075 ENSMUST00000281793.1 Gm45075 (from geneSymbol) uc333lme.1 uc333lme.1 
ENSMUST00000281800.1 ENSMUSG00000127372 ENSMUST00000281800.1 ENSMUSG00000127372 (from geneSymbol) uc333lml.1 uc333lml.1 
ENSMUST00000281804.1 ENSMUSG00000127373 ENSMUST00000281804.1 ENSMUSG00000127373 (from geneSymbol) uc333lmp.1 uc333lmp.1 
ENSMUST00000281805.1 ENSMUSG00000127374 ENSMUST00000281805.1 ENSMUSG00000127374 (from geneSymbol) uc333lmq.1 uc333lmq.1 
ENSMUST00000281808.1 ENSMUSG00000127375 ENSMUST00000281808.1 ENSMUSG00000127375 (from geneSymbol) uc333lmt.1 uc333lmt.1 
ENSMUST00000281809.1 ENSMUSG00000127376 ENSMUST00000281809.1 ENSMUSG00000127376 (from geneSymbol) uc333lmu.1 uc333lmu.1 
ENSMUST00000281810.1 ENSMUSG00000127377 ENSMUST00000281810.1 ENSMUSG00000127377 (from geneSymbol) uc333lmv.1 uc333lmv.1 
ENSMUST00000281818.1 ENSMUSG00000127378 ENSMUST00000281818.1 ENSMUSG00000127378 (from geneSymbol) uc333lnc.1 uc333lnc.1 
ENSMUST00000281820.1 ENSMUSG00000127379 ENSMUST00000281820.1 ENSMUSG00000127379 (from geneSymbol) uc333lne.1 uc333lne.1 
ENSMUST00000281823.1 ENSMUSG00000127380 ENSMUST00000281823.1 predicted gene, 52148 (from RefSeq NR_168521.1) NR_168521 uc333lnh.1 uc333lnh.1 
ENSMUST00000281824.1 ENSMUSG00000127381 ENSMUST00000281824.1 ENSMUSG00000127381 (from geneSymbol) uc333lni.1 uc333lni.1 
ENSMUST00000281826.1 Gm13483 ENSMUST00000281826.1 Gm13483 (from geneSymbol) AK142467 uc333lnk.1 uc333lnk.1 
ENSMUST00000281829.1 ENSMUSG00000127383 ENSMUST00000281829.1 ENSMUSG00000127383 (from geneSymbol) uc333lnm.1 uc333lnm.1 
ENSMUST00000281832.1 Speer9-ps1 ENSMUST00000281832.1 Speer9-ps1 (from geneSymbol) AK015142 uc333lnp.1 uc333lnp.1 
ENSMUST00000281847.1 ENSMUSG00000127384 ENSMUST00000281847.1 ENSMUSG00000127384 (from geneSymbol) uc333loe.1 uc333loe.1 
ENSMUST00000281877.1 ENSMUSG00000127385 ENSMUST00000281877.1 ENSMUSG00000127385 (from geneSymbol) uc333lpi.1 uc333lpi.1 
ENSMUST00000281878.1 ENSMUSG00000127386 ENSMUST00000281878.1 ENSMUSG00000127386 (from geneSymbol) uc333lpj.1 uc333lpj.1 
ENSMUST00000281883.1 ENSMUSG00000127387 ENSMUST00000281883.1 ENSMUSG00000127387 (from geneSymbol) uc333lpo.1 uc333lpo.1 
ENSMUST00000281893.1 ENSMUSG00000127388 ENSMUST00000281893.1 ENSMUSG00000127388 (from geneSymbol) uc333lpy.1 uc333lpy.1 
ENSMUST00000281896.1 ENSMUSG00000127389 ENSMUST00000281896.1 ENSMUSG00000127389 (from geneSymbol) uc333lqb.1 uc333lqb.1 
ENSMUST00000281897.1 ENSMUSG00000127390 ENSMUST00000281897.1 ENSMUSG00000127390 (from geneSymbol) uc333lqc.1 uc333lqc.1 
ENSMUST00000281899.1 ENSMUSG00000127391 ENSMUST00000281899.1 ENSMUSG00000127391 (from geneSymbol) uc333lqe.1 uc333lqe.1 
ENSMUST00000281907.1 ENSMUSG00000127393 ENSMUST00000281907.1 ENSMUSG00000127393 (from geneSymbol) uc333lql.1 uc333lql.1 
ENSMUST00000281908.1 ENSMUSG00000127394 ENSMUST00000281908.1 ENSMUSG00000127394 (from geneSymbol) uc333lqm.1 uc333lqm.1 
ENSMUST00000281910.1 ENSMUSG00000127395 ENSMUST00000281910.1 ENSMUSG00000127395 (from geneSymbol) uc333lqo.1 uc333lqo.1 
ENSMUST00000281911.1 ENSMUSG00000127396 ENSMUST00000281911.1 ENSMUSG00000127396 (from geneSymbol) LF195355 uc333lqp.1 uc333lqp.1 
ENSMUST00000281912.1 ENSMUSG00000127397 ENSMUST00000281912.1 ENSMUSG00000127397 (from geneSymbol) uc333lqq.1 uc333lqq.1 
ENSMUST00000281913.1 ENSMUSG00000127398 ENSMUST00000281913.1 ENSMUSG00000127398 (from geneSymbol) uc333lqr.1 uc333lqr.1 
ENSMUST00000281914.1 ENSMUSG00000127399 ENSMUST00000281914.1 ENSMUSG00000127399 (from geneSymbol) uc333lqs.1 uc333lqs.1 
ENSMUST00000281932.1 2610005L07Rik ENSMUST00000281932.1 2610005L07Rik (from geneSymbol) AK081879 uc333lqu.1 uc333lqu.1 
ENSMUST00000282133.1 ENSMUSG00000127400 ENSMUST00000282133.1 ENSMUSG00000127400 (from geneSymbol) AK161360 uc333lym.1 uc333lym.1 
ENSMUST00000282134.1 Gm34552 ENSMUST00000282134.1 Gm34552 (from geneSymbol) uc333lyn.1 uc333lyn.1 
ENSMUST00000282142.1 ENSMUSG00000127401 ENSMUST00000282142.1 ENSMUSG00000127401 (from geneSymbol) uc333lyv.1 uc333lyv.1 
ENSMUST00000282143.1 ENSMUSG00000127402 ENSMUST00000282143.1 ENSMUSG00000127402 (from geneSymbol) uc333lyw.1 uc333lyw.1 
ENSMUST00000282144.1 ENSMUSG00000127403 ENSMUST00000282144.1 ENSMUSG00000127403 (from geneSymbol) uc333lyx.1 uc333lyx.1 
ENSMUST00000282146.1 ENSMUSG00000127404 ENSMUST00000282146.1 ENSMUSG00000127404 (from geneSymbol) uc333lyz.1 uc333lyz.1 
ENSMUST00000282147.1 Gm48893 ENSMUST00000282147.1 Gm48893 (from geneSymbol) uc333lza.1 uc333lza.1 
ENSMUST00000282148.1 ENSMUSG00000127405 ENSMUST00000282148.1 ENSMUSG00000127405 (from geneSymbol) uc333lzb.1 uc333lzb.1 
ENSMUST00000282150.1 ENSMUSG00000127407 ENSMUST00000282150.1 ENSMUSG00000127407 (from geneSymbol) uc333lzc.1 uc333lzc.1 
ENSMUST00000282151.1 ENSMUSG00000127408 ENSMUST00000282151.1 ENSMUSG00000127408 (from geneSymbol) uc333lzd.1 uc333lzd.1 
ENSMUST00000282152.1 Gm36347 ENSMUST00000282152.1 Gm36347 (from geneSymbol) uc333lze.1 uc333lze.1 
ENSMUST00000282159.1 ENSMUSG00000127409 ENSMUST00000282159.1 ENSMUSG00000127409 (from geneSymbol) uc333lzl.1 uc333lzl.1 
ENSMUST00000282160.1 ENSMUSG00000127410 ENSMUST00000282160.1 ENSMUSG00000127410 (from geneSymbol) uc333lzm.1 uc333lzm.1 
ENSMUST00000282172.1 ENSMUSG00000127411 ENSMUST00000282172.1 ENSMUSG00000127411 (from geneSymbol) uc333lzy.1 uc333lzy.1 
ENSMUST00000282186.1 ENSMUSG00000127412 ENSMUST00000282186.1 ENSMUSG00000127412 (from geneSymbol) uc333mam.1 uc333mam.1 
ENSMUST00000282188.1 ENSMUSG00000127413 ENSMUST00000282188.1 ENSMUSG00000127413 (from geneSymbol) uc333mao.1 uc333mao.1 
ENSMUST00000282226.1 ENSMUSG00000127414 ENSMUST00000282226.1 ENSMUSG00000127414 (from geneSymbol) uc333mca.1 uc333mca.1 
ENSMUST00000282227.1 ENSMUSG00000127415 ENSMUST00000282227.1 ENSMUSG00000127415 (from geneSymbol) uc333mcb.1 uc333mcb.1 
ENSMUST00000282229.1 ENSMUSG00000127417 ENSMUST00000282229.1 ENSMUSG00000127417 (from geneSymbol) LF203264 uc333mcc.1 uc333mcc.1 
ENSMUST00000282230.1 4930405A21Rik ENSMUST00000282230.1 4930405A21Rik (from geneSymbol) AK015092 uc333mcd.1 uc333mcd.1 
ENSMUST00000282242.1 ENSMUSG00000127418 ENSMUST00000282242.1 ENSMUSG00000127418 (from geneSymbol) uc333mcp.1 uc333mcp.1 
ENSMUST00000282243.1 ENSMUSG00000127419 ENSMUST00000282243.1 ENSMUSG00000127419 (from geneSymbol) uc333mcq.1 uc333mcq.1 
ENSMUST00000282247.1 ENSMUSG00000127420 ENSMUST00000282247.1 ENSMUSG00000127420 (from geneSymbol) uc333mcu.1 uc333mcu.1 
ENSMUST00000282255.1 ENSMUSG00000127421 ENSMUST00000282255.1 ENSMUSG00000127421 (from geneSymbol) uc333mdc.1 uc333mdc.1 
ENSMUST00000282303.1 ENSMUSG00000127423 ENSMUST00000282303.1 ENSMUSG00000127423 (from geneSymbol) uc333mex.1 uc333mex.1 
ENSMUST00000282304.1 ENSMUSG00000127424 ENSMUST00000282304.1 ENSMUSG00000127424 (from geneSymbol) uc333mey.1 uc333mey.1 
ENSMUST00000282322.1 ENSMUSG00000127425 ENSMUST00000282322.1 ENSMUSG00000127425 (from geneSymbol) uc333mfq.1 uc333mfq.1 
ENSMUST00000282323.1 ENSMUSG00000127426 ENSMUST00000282323.1 ENSMUSG00000127426 (from geneSymbol) uc333mfr.1 uc333mfr.1 
ENSMUST00000282324.1 ENSMUSG00000127427 ENSMUST00000282324.1 ENSMUSG00000127427 (from geneSymbol) uc333mfs.1 uc333mfs.1 
ENSMUST00000282326.1 ENSMUSG00000127428 ENSMUST00000282326.1 ENSMUSG00000127428 (from geneSymbol) uc333mfu.1 uc333mfu.1 
ENSMUST00000282329.1 ENSMUSG00000127429 ENSMUST00000282329.1 ENSMUSG00000127429 (from geneSymbol) uc333mfx.1 uc333mfx.1 
ENSMUST00000282331.1 ENSMUSG00000127430 ENSMUST00000282331.1 ENSMUSG00000127430 (from geneSymbol) uc333mfz.1 uc333mfz.1 
ENSMUST00000282332.1 ENSMUSG00000127431 ENSMUST00000282332.1 ENSMUSG00000127431 (from geneSymbol) uc333mga.1 uc333mga.1 
ENSMUST00000282333.1 ENSMUSG00000127432 ENSMUST00000282333.1 ENSMUSG00000127432 (from geneSymbol) uc333mgb.1 uc333mgb.1 
ENSMUST00000282336.1 ENSMUSG00000127433 ENSMUST00000282336.1 ENSMUSG00000127433 (from geneSymbol) uc333mge.1 uc333mge.1 
ENSMUST00000282337.1 ENSMUSG00000127434 ENSMUST00000282337.1 ENSMUSG00000127434 (from geneSymbol) uc333mgf.1 uc333mgf.1 
ENSMUST00000282339.1 ENSMUSG00000127435 ENSMUST00000282339.1 predicted gene, 36809 (from RefSeq NR_168692.1) NR_168692 uc333mgh.1 uc333mgh.1 
ENSMUST00000282364.1 ENSMUSG00000127436 ENSMUST00000282364.1 ENSMUSG00000127436 (from geneSymbol) uc333mhg.1 uc333mhg.1 
ENSMUST00000282367.1 ENSMUSG00000127437 ENSMUST00000282367.1 ENSMUSG00000127437 (from geneSymbol) uc333mhj.1 uc333mhj.1 
ENSMUST00000282368.1 ENSMUSG00000127438 ENSMUST00000282368.1 ENSMUSG00000127438 (from geneSymbol) uc333mhk.1 uc333mhk.1 
ENSMUST00000282370.1 ENSMUSG00000127439 ENSMUST00000282370.1 ENSMUSG00000127439 (from geneSymbol) uc333mhm.1 uc333mhm.1 
ENSMUST00000282374.1 ENSMUSG00000127440 ENSMUST00000282374.1 ENSMUSG00000127440 (from geneSymbol) uc333mhq.1 uc333mhq.1 
ENSMUST00000282377.1 4930412F09Rik ENSMUST00000282377.1 4930412F09Rik (from geneSymbol) AK015119 uc333mht.1 uc333mht.1 
ENSMUST00000282383.1 ENSMUSG00000127441 ENSMUST00000282383.1 ENSMUSG00000127441 (from geneSymbol) uc333mhz.1 uc333mhz.1 
ENSMUST00000282384.1 ENSMUSG00000127442 ENSMUST00000282384.1 ENSMUSG00000127442 (from geneSymbol) uc333mia.1 uc333mia.1 
ENSMUST00000282385.1 ENSMUSG00000127443 ENSMUST00000282385.1 ENSMUSG00000127443 (from geneSymbol) uc333mib.1 uc333mib.1 
ENSMUST00000282387.1 ENSMUSG00000127444 ENSMUST00000282387.1 ENSMUSG00000127444 (from geneSymbol) uc333mid.1 uc333mid.1 
ENSMUST00000282388.1 ENSMUSG00000127445 ENSMUST00000282388.1 ENSMUSG00000127445 (from geneSymbol) uc333mie.1 uc333mie.1 
ENSMUST00000282403.1 ENSMUSG00000127446 ENSMUST00000282403.1 ENSMUSG00000127446 (from geneSymbol) uc333mit.1 uc333mit.1 
ENSMUST00000282404.1 ENSMUSG00000127447 ENSMUST00000282404.1 ENSMUSG00000127447 (from geneSymbol) uc333miu.1 uc333miu.1 
ENSMUST00000282405.1 ENSMUSG00000127448 ENSMUST00000282405.1 ENSMUSG00000127448 (from geneSymbol) uc333miv.1 uc333miv.1 
ENSMUST00000282408.1 ENSMUSG00000127449 ENSMUST00000282408.1 ENSMUSG00000127449 (from geneSymbol) uc333miy.1 uc333miy.1 
ENSMUST00000282419.1 ENSMUSG00000127450 ENSMUST00000282419.1 ENSMUSG00000127450 (from geneSymbol) uc333mjj.1 uc333mjj.1 
ENSMUST00000282429.1 ENSMUSG00000127451 ENSMUST00000282429.1 ENSMUSG00000127451 (from geneSymbol) uc333mjt.1 uc333mjt.1 
ENSMUST00000282430.1 ENSMUSG00000127452 ENSMUST00000282430.1 ENSMUSG00000127452 (from geneSymbol) uc333mju.1 uc333mju.1 
ENSMUST00000282431.1 ENSMUSG00000127453 ENSMUST00000282431.1 ENSMUSG00000127453 (from geneSymbol) uc333mjv.1 uc333mjv.1 
ENSMUST00000282432.1 ENSMUSG00000127454 ENSMUST00000282432.1 ENSMUSG00000127454 (from geneSymbol) uc333mjw.1 uc333mjw.1 
ENSMUST00000282435.1 ENSMUSG00000127456 ENSMUST00000282435.1 ENSMUSG00000127456 (from geneSymbol) uc333mjy.1 uc333mjy.1 
ENSMUST00000282442.1 Gm15835 ENSMUST00000282442.1 Gm15835 (from geneSymbol) uc333mkf.1 uc333mkf.1 
ENSMUST00000282444.1 ENSMUSG00000127457 ENSMUST00000282444.1 ENSMUSG00000127457 (from geneSymbol) uc333mkh.1 uc333mkh.1 
ENSMUST00000282446.1 ENSMUSG00000127458 ENSMUST00000282446.1 ENSMUSG00000127458 (from geneSymbol) uc333mkj.1 uc333mkj.1 
ENSMUST00000282447.1 Gm19500 ENSMUST00000282447.1 Gm19500 (from geneSymbol) AK034468 uc333mkk.1 uc333mkk.1 
ENSMUST00000282453.1 6820431F20Rik ENSMUST00000282453.1 6820431F20Rik (from geneSymbol) BC058969 uc333mko.1 uc333mko.1 
ENSMUST00000282490.1 Gm56779 ENSMUST00000282490.1 Gm56779 (from geneSymbol) uc333mlw.1 uc333mlw.1 
ENSMUST00000282509.1 ENSMUSG00000127459 ENSMUST00000282509.1 ENSMUSG00000127459 (from geneSymbol) uc333mmp.1 uc333mmp.1 
ENSMUST00000282513.1 ENSMUSG00000127460 ENSMUST00000282513.1 ENSMUSG00000127460 (from geneSymbol) uc333mmt.1 uc333mmt.1 
ENSMUST00000282514.1 ENSMUSG00000127461 ENSMUST00000282514.1 ENSMUSG00000127461 (from geneSymbol) uc333mmu.1 uc333mmu.1 
ENSMUST00000282517.1 C030013C21Rik ENSMUST00000282517.1 C030013C21Rik (from geneSymbol) uc333mmw.1 uc333mmw.1 
ENSMUST00000282520.1 ENSMUSG00000127463 ENSMUST00000282520.1 ENSMUSG00000127463 (from geneSymbol) uc333mmy.1 uc333mmy.1 
ENSMUST00000282521.1 ENSMUSG00000127464 ENSMUST00000282521.1 ENSMUSG00000127464 (from geneSymbol) uc333mmz.1 uc333mmz.1 
ENSMUST00000282526.1 ENSMUSG00000127465 ENSMUST00000282526.1 ENSMUSG00000127465 (from geneSymbol) uc333mne.1 uc333mne.1 
ENSMUST00000282527.1 ENSMUSG00000127466 ENSMUST00000282527.1 ENSMUSG00000127466 (from geneSymbol) LF202697 uc333mnf.1 uc333mnf.1 
ENSMUST00000282528.1 ENSMUSG00000127467 ENSMUST00000282528.1 ENSMUSG00000127467 (from geneSymbol) uc333mng.1 uc333mng.1 
ENSMUST00000282531.1 1700110K17Rik ENSMUST00000282531.1 1700110K17Rik (from geneSymbol) AK007162 uc333mnj.1 uc333mnj.1 
ENSMUST00000282537.1 Gm34093 ENSMUST00000282537.1 Gm34093 (from geneSymbol) AK042292 uc333mnp.1 uc333mnp.1 
ENSMUST00000282544.1 ENSMUSG00000127468 ENSMUST00000282544.1 ENSMUSG00000127468 (from geneSymbol) uc333mnw.1 uc333mnw.1 
ENSMUST00000282549.1 Gm12927 ENSMUST00000282549.1 Gm12927 (from geneSymbol) uc333mob.1 uc333mob.1 
ENSMUST00000282555.1 ENSMUSG00000127469 ENSMUST00000282555.1 ENSMUSG00000127469 (from geneSymbol) uc333moh.1 uc333moh.1 
ENSMUST00000282557.1 ENSMUSG00000127470 ENSMUST00000282557.1 ENSMUSG00000127470 (from geneSymbol) uc333moj.1 uc333moj.1 
ENSMUST00000282558.1 ENSMUSG00000127471 ENSMUST00000282558.1 ENSMUSG00000127471 (from geneSymbol) uc333mok.1 uc333mok.1 
ENSMUST00000282559.1 ENSMUSG00000127472 ENSMUST00000282559.1 ENSMUSG00000127472 (from geneSymbol) uc333mol.1 uc333mol.1 
ENSMUST00000282560.1 ENSMUSG00000127473 ENSMUST00000282560.1 ENSMUSG00000127473 (from geneSymbol) uc333mom.1 uc333mom.1 
ENSMUST00000282562.1 ENSMUSG00000127474 ENSMUST00000282562.1 ENSMUSG00000127474 (from geneSymbol) uc333moo.1 uc333moo.1 
ENSMUST00000282565.1 ENSMUSG00000127475 ENSMUST00000282565.1 ENSMUSG00000127475 (from geneSymbol) uc333mor.1 uc333mor.1 
ENSMUST00000282566.1 ENSMUSG00000127476 ENSMUST00000282566.1 ENSMUSG00000127476 (from geneSymbol) uc333mos.1 uc333mos.1 
ENSMUST00000282568.1 ENSMUSG00000127477 ENSMUST00000282568.1 ENSMUSG00000127477 (from geneSymbol) uc333mou.1 uc333mou.1 
ENSMUST00000282570.1 ENSMUSG00000127478 ENSMUST00000282570.1 ENSMUSG00000127478 (from geneSymbol) uc333mow.1 uc333mow.1 
ENSMUST00000282572.1 ENSMUSG00000127479 ENSMUST00000282572.1 ENSMUSG00000127479 (from geneSymbol) uc333moy.1 uc333moy.1 
ENSMUST00000282573.1 ENSMUSG00000127480 ENSMUST00000282573.1 ENSMUSG00000127480 (from geneSymbol) uc333moz.1 uc333moz.1 
ENSMUST00000282574.1 ENSMUSG00000127481 ENSMUST00000282574.1 ENSMUSG00000127481 (from geneSymbol) uc333mpa.1 uc333mpa.1 
ENSMUST00000282576.1 ENSMUSG00000127482 ENSMUST00000282576.1 ENSMUSG00000127482 (from geneSymbol) uc333mpc.1 uc333mpc.1 
ENSMUST00000282577.1 ENSMUSG00000127483 ENSMUST00000282577.1 ENSMUSG00000127483 (from geneSymbol) uc333mpd.1 uc333mpd.1 
ENSMUST00000282579.1 Gm34866 ENSMUST00000282579.1 Gm34866 (from geneSymbol) AK006921 uc333mpf.1 uc333mpf.1 
ENSMUST00000282585.1 ENSMUSG00000127484 ENSMUST00000282585.1 ENSMUSG00000127484 (from geneSymbol) uc333mpl.1 uc333mpl.1 
ENSMUST00000282588.1 ENSMUSG00000127485 ENSMUST00000282588.1 ENSMUSG00000127485 (from geneSymbol) uc333mpo.1 uc333mpo.1 
ENSMUST00000282589.1 ENSMUSG00000127486 ENSMUST00000282589.1 ENSMUSG00000127486 (from geneSymbol) uc333mpp.1 uc333mpp.1 
ENSMUST00000282591.1 ENSMUSG00000127487 ENSMUST00000282591.1 ENSMUSG00000127487 (from geneSymbol) LF200308 uc333mpr.1 uc333mpr.1 
ENSMUST00000282596.1 ENSMUSG00000127488 ENSMUST00000282596.1 ENSMUSG00000127488 (from geneSymbol) uc333mpw.1 uc333mpw.1 
ENSMUST00000282600.1 ENSMUSG00000127489 ENSMUST00000282600.1 ENSMUSG00000127489 (from geneSymbol) uc333mqa.1 uc333mqa.1 
ENSMUST00000282603.1 ENSMUSG00000127490 ENSMUST00000282603.1 ENSMUSG00000127490 (from geneSymbol) uc333mqd.1 uc333mqd.1 
ENSMUST00000282635.1 ENSMUSG00000127491 ENSMUST00000282635.1 ENSMUSG00000127491 (from geneSymbol) uc333mrj.1 uc333mrj.1 
ENSMUST00000282638.1 ENSMUSG00000127492 ENSMUST00000282638.1 ENSMUSG00000127492 (from geneSymbol) uc333mrm.1 uc333mrm.1 
ENSMUST00000282639.1 ENSMUSG00000127493 ENSMUST00000282639.1 ENSMUSG00000127493 (from geneSymbol) uc333mrn.1 uc333mrn.1 
ENSMUST00000282640.1 ENSMUSG00000127494 ENSMUST00000282640.1 ENSMUSG00000127494 (from geneSymbol) uc333mro.1 uc333mro.1 
ENSMUST00000282642.1 ENSMUSG00000127495 ENSMUST00000282642.1 ENSMUSG00000127495 (from geneSymbol) uc333mrq.1 uc333mrq.1 
ENSMUST00000282644.1 ENSMUSG00000127496 ENSMUST00000282644.1 ENSMUSG00000127496 (from geneSymbol) uc333mrs.1 uc333mrs.1 
ENSMUST00000282645.1 ENSMUSG00000127497 ENSMUST00000282645.1 ENSMUSG00000127497 (from geneSymbol) uc333mrt.1 uc333mrt.1 
ENSMUST00000282650.1 ENSMUSG00000121360 ENSMUST00000282650.1 ENSMUSG00000121360 (from geneSymbol) AF074460 uc333mry.1 uc333mry.1 
ENSMUST00000282659.1 ENSMUSG00000127498 ENSMUST00000282659.1 ENSMUSG00000127498 (from geneSymbol) uc333msh.1 uc333msh.1 
ENSMUST00000282688.1 ENSMUSG00000127499 ENSMUST00000282688.1 ENSMUSG00000127499 (from geneSymbol) uc333mtk.1 uc333mtk.1 
ENSMUST00000282694.1 ENSMUSG00000127500 ENSMUST00000282694.1 ENSMUSG00000127500 (from geneSymbol) uc333mtq.1 uc333mtq.1 
ENSMUST00000282699.1 ENSMUSG00000127501 ENSMUST00000282699.1 ENSMUSG00000127501 (from geneSymbol) uc333mtv.1 uc333mtv.1 
ENSMUST00000282703.1 ENSMUSG00000127502 ENSMUST00000282703.1 ENSMUSG00000127502 (from geneSymbol) uc333mtz.1 uc333mtz.1 
ENSMUST00000282705.1 ENSMUSG00000127503 ENSMUST00000282705.1 ENSMUSG00000127503 (from geneSymbol) uc333mub.1 uc333mub.1 
ENSMUST00000282706.1 ENSMUSG00000127504 ENSMUST00000282706.1 ENSMUSG00000127504 (from geneSymbol) uc333muc.1 uc333muc.1 
ENSMUST00000282707.1 ENSMUSG00000127505 ENSMUST00000282707.1 ENSMUSG00000127505 (from geneSymbol) LF197854 uc333mud.1 uc333mud.1 
ENSMUST00000282708.1 ENSMUSG00000127506 ENSMUST00000282708.1 ENSMUSG00000127506 (from geneSymbol) uc333mue.1 uc333mue.1 
ENSMUST00000282712.1 ENSMUSG00000127507 ENSMUST00000282712.1 ENSMUSG00000127507 (from geneSymbol) uc333mui.1 uc333mui.1 
ENSMUST00000282714.1 ENSMUSG00000127508 ENSMUST00000282714.1 ENSMUSG00000127508 (from geneSymbol) uc333muk.1 uc333muk.1 
ENSMUST00000282715.1 ENSMUSG00000127509 ENSMUST00000282715.1 ENSMUSG00000127509 (from geneSymbol) uc333mul.1 uc333mul.1 
ENSMUST00000282717.1 ENSMUSG00000127510 ENSMUST00000282717.1 ENSMUSG00000127510 (from geneSymbol) uc333mum.1 uc333mum.1 
ENSMUST00000282723.1 Gm21283 ENSMUST00000282723.1 Gm21283 (from geneSymbol) AK076897 uc333mus.1 uc333mus.1 
ENSMUST00000282734.1 ENSMUSG00000127512 ENSMUST00000282734.1 ENSMUSG00000127512 (from geneSymbol) uc333mvd.1 uc333mvd.1 
ENSMUST00000282736.1 ENSMUSG00000127513 ENSMUST00000282736.1 ENSMUSG00000127513 (from geneSymbol) uc333mvf.1 uc333mvf.1 
ENSMUST00000282737.1 ENSMUSG00000127514 ENSMUST00000282737.1 ENSMUSG00000127514 (from geneSymbol) uc333mvg.1 uc333mvg.1 
ENSMUST00000282738.1 Gm49224 ENSMUST00000282738.1 Gm49224 (from geneSymbol) uc333mvh.1 uc333mvh.1 
ENSMUST00000282739.1 ENSMUSG00000127515 ENSMUST00000282739.1 ENSMUSG00000127515 (from geneSymbol) uc333mvi.1 uc333mvi.1 
ENSMUST00000282741.1 ENSMUSG00000127516 ENSMUST00000282741.1 ENSMUSG00000127516 (from geneSymbol) uc333mvk.1 uc333mvk.1 
ENSMUST00000282742.1 ENSMUSG00000127517 ENSMUST00000282742.1 ENSMUSG00000127517 (from geneSymbol) uc333mvl.1 uc333mvl.1 
ENSMUST00000282744.1 ENSMUSG00000127518 ENSMUST00000282744.1 ENSMUSG00000127518 (from geneSymbol) uc333mvn.1 uc333mvn.1 
ENSMUST00000282748.1 ENSMUSG00000127519 ENSMUST00000282748.1 ENSMUSG00000127519 (from geneSymbol) uc333mvr.1 uc333mvr.1 
ENSMUST00000282750.1 ENSMUSG00000127520 ENSMUST00000282750.1 ENSMUSG00000127520 (from geneSymbol) uc333mvt.1 uc333mvt.1 
ENSMUST00000282751.1 ENSMUSG00000127521 ENSMUST00000282751.1 ENSMUSG00000127521 (from geneSymbol) uc333mvu.1 uc333mvu.1 
ENSMUST00000282753.1 ENSMUSG00000127522 ENSMUST00000282753.1 ENSMUSG00000127522 (from geneSymbol) uc333mvw.1 uc333mvw.1 
ENSMUST00000282754.1 1700126A01Rik ENSMUST00000282754.1 1700126A01Rik (from geneSymbol) uc333mvx.1 uc333mvx.1 
ENSMUST00000282773.1 ENSMUSG00000127523 ENSMUST00000282773.1 ENSMUSG00000127523 (from geneSymbol) uc333mwq.1 uc333mwq.1 
ENSMUST00000282774.1 ENSMUSG00000127524 ENSMUST00000282774.1 ENSMUSG00000127524 (from geneSymbol) uc333mwr.1 uc333mwr.1 
ENSMUST00000282777.1 ENSMUSG00000127525 ENSMUST00000282777.1 ENSMUSG00000127525 (from geneSymbol) uc333mwu.1 uc333mwu.1 
ENSMUST00000282781.1 ENSMUSG00000127526 ENSMUST00000282781.1 ENSMUSG00000127526 (from geneSymbol) uc333mwy.1 uc333mwy.1 
ENSMUST00000282785.1 ENSMUSG00000127527 ENSMUST00000282785.1 ENSMUSG00000127527 (from geneSymbol) uc333mxc.1 uc333mxc.1 
ENSMUST00000282786.1 Gm41846 ENSMUST00000282786.1 Gm41846 (from geneSymbol) uc333mxd.1 uc333mxd.1 
ENSMUST00000282788.1 ENSMUSG00000127528 ENSMUST00000282788.1 ENSMUSG00000127528 (from geneSymbol) uc333mxf.1 uc333mxf.1 
ENSMUST00000282790.1 Gm38843 ENSMUST00000282790.1 Gm38843 (from geneSymbol) uc333mxh.1 uc333mxh.1 
ENSMUST00000282806.1 ENSMUSG00000127529 ENSMUST00000282806.1 ENSMUSG00000127529 (from geneSymbol) uc333mxx.1 uc333mxx.1 
ENSMUST00000282807.1 ENSMUSG00000127530 ENSMUST00000282807.1 ENSMUSG00000127530 (from geneSymbol) uc333mxy.1 uc333mxy.1 
ENSMUST00000282808.1 ENSMUSG00000127531 ENSMUST00000282808.1 ENSMUSG00000127531 (from geneSymbol) uc333mxz.1 uc333mxz.1 
ENSMUST00000282809.1 ENSMUSG00000127532 ENSMUST00000282809.1 ENSMUSG00000127532 (from geneSymbol) uc333mya.1 uc333mya.1 
ENSMUST00000282811.1 Gm50164 ENSMUST00000282811.1 Gm50164 (from geneSymbol) uc333myc.1 uc333myc.1 
ENSMUST00000282812.1 ENSMUSG00000127533 ENSMUST00000282812.1 ENSMUSG00000127533 (from geneSymbol) uc333myd.1 uc333myd.1 
ENSMUST00000282813.1 ENSMUSG00000127534 ENSMUST00000282813.1 ENSMUSG00000127534 (from geneSymbol) uc333mye.1 uc333mye.1 
ENSMUST00000282814.1 ENSMUSG00000127535 ENSMUST00000282814.1 ENSMUSG00000127535 (from geneSymbol) AK144914 uc333myf.1 uc333myf.1 
ENSMUST00000282815.1 ENSMUSG00000127536 ENSMUST00000282815.1 ENSMUSG00000127536 (from geneSymbol) uc333myg.1 uc333myg.1 
ENSMUST00000282825.1 ENSMUSG00000127537 ENSMUST00000282825.1 ENSMUSG00000127537 (from geneSymbol) uc333myq.1 uc333myq.1 
ENSMUST00000282826.1 ENSMUSG00000127538 ENSMUST00000282826.1 ENSMUSG00000127538 (from geneSymbol) uc333myr.1 uc333myr.1 
ENSMUST00000282829.1 Gm44257 ENSMUST00000282829.1 Gm44257 (from geneSymbol) AK043376 uc333myu.1 uc333myu.1 
ENSMUST00000282847.1 ENSMUSG00000127539 ENSMUST00000282847.1 ENSMUSG00000127539 (from geneSymbol) uc333mzm.1 uc333mzm.1 
ENSMUST00000282857.1 ENSMUSG00000127540 ENSMUST00000282857.1 ENSMUSG00000127540 (from geneSymbol) uc333mzw.1 uc333mzw.1 
ENSMUST00000282858.1 ENSMUSG00000127541 ENSMUST00000282858.1 ENSMUSG00000127541 (from geneSymbol) uc333mzx.1 uc333mzx.1 
ENSMUST00000282859.1 ENSMUSG00000127542 ENSMUST00000282859.1 ENSMUSG00000127542 (from geneSymbol) uc333mzy.1 uc333mzy.1 
ENSMUST00000282863.1 ENSMUSG00000127543 ENSMUST00000282863.1 ENSMUSG00000127543 (from geneSymbol) uc333nac.1 uc333nac.1 
ENSMUST00000282874.1 ENSMUSG00000127544 ENSMUST00000282874.1 ENSMUSG00000127544 (from geneSymbol) uc333nan.1 uc333nan.1 
ENSMUST00000282875.1 ENSMUSG00000127545 ENSMUST00000282875.1 ENSMUSG00000127545 (from geneSymbol) uc333nao.1 uc333nao.1 
ENSMUST00000282877.1 ENSMUSG00000127546 ENSMUST00000282877.1 ENSMUSG00000127546 (from geneSymbol) uc333naq.1 uc333naq.1 
ENSMUST00000282878.1 ENSMUSG00000127547 ENSMUST00000282878.1 ENSMUSG00000127547 (from geneSymbol) uc333nar.1 uc333nar.1 
ENSMUST00000282880.1 ENSMUSG00000127548 ENSMUST00000282880.1 ENSMUSG00000127548 (from geneSymbol) uc333nat.1 uc333nat.1 
ENSMUST00000282881.1 ENSMUSG00000127549 ENSMUST00000282881.1 ENSMUSG00000127549 (from geneSymbol) uc333nau.1 uc333nau.1 
ENSMUST00000282906.1 ENSMUSG00000127550 ENSMUST00000282906.1 ENSMUSG00000127550 (from geneSymbol) uc333nbt.1 uc333nbt.1 
ENSMUST00000282911.1 ENSMUSG00000127551 ENSMUST00000282911.1 ENSMUSG00000127551 (from geneSymbol) uc333nby.1 uc333nby.1 
ENSMUST00000282974.1 Gm43001 ENSMUST00000282974.1 Gm43001 (from geneSymbol) uc333nej.1 uc333nej.1 
ENSMUST00000283003.1 ENSMUSG00000127552 ENSMUST00000283003.1 ENSMUSG00000127552 (from geneSymbol) uc333nfm.1 uc333nfm.1 
ENSMUST00000283012.1 ENSMUSG00000127553 ENSMUST00000283012.1 ENSMUSG00000127553 (from geneSymbol) uc333nfv.1 uc333nfv.1 
ENSMUST00000283013.1 ENSMUSG00000127554 ENSMUST00000283013.1 ENSMUSG00000127554 (from geneSymbol) AK076593 uc333nfw.1 uc333nfw.1 
ENSMUST00000283017.1 ENSMUSG00000127555 ENSMUST00000283017.1 ENSMUSG00000127555 (from geneSymbol) uc333nga.1 uc333nga.1 
ENSMUST00000283023.1 ENSMUSG00000127556 ENSMUST00000283023.1 ENSMUSG00000127556 (from geneSymbol) uc333ngg.1 uc333ngg.1 
ENSMUST00000283024.1 ENSMUSG00000127557 ENSMUST00000283024.1 ENSMUSG00000127557 (from geneSymbol) uc333ngh.1 uc333ngh.1 
ENSMUST00000283025.1 ENSMUSG00000127558 ENSMUST00000283025.1 ENSMUSG00000127558 (from geneSymbol) uc333ngi.1 uc333ngi.1 
ENSMUST00000283026.1 ENSMUSG00000127559 ENSMUST00000283026.1 ENSMUSG00000127559 (from geneSymbol) uc333ngj.1 uc333ngj.1 
ENSMUST00000283032.1 Gm34316 ENSMUST00000283032.1 Gm34316 (from geneSymbol) uc333ngp.1 uc333ngp.1 
ENSMUST00000283041.1 ENSMUSG00000127560 ENSMUST00000283041.1 ENSMUSG00000127560 (from geneSymbol) uc333ngy.1 uc333ngy.1 
ENSMUST00000283042.1 ENSMUSG00000127561 ENSMUST00000283042.1 ENSMUSG00000127561 (from geneSymbol) uc333ngz.1 uc333ngz.1 
ENSMUST00000283044.1 ENSMUSG00000127562 ENSMUST00000283044.1 ENSMUSG00000127562 (from geneSymbol) uc333nhb.1 uc333nhb.1 
ENSMUST00000283045.1 Gm16240 ENSMUST00000283045.1 Gm16240 (from geneSymbol) uc333nhc.1 uc333nhc.1 
ENSMUST00000283049.1 ENSMUSG00000127563 ENSMUST00000283049.1 ENSMUSG00000127563 (from geneSymbol) uc333nhg.1 uc333nhg.1 
ENSMUST00000283050.1 ENSMUSG00000127564 ENSMUST00000283050.1 ENSMUSG00000127564 (from geneSymbol) uc333nhh.1 uc333nhh.1 
ENSMUST00000283051.1 ENSMUSG00000127565 ENSMUST00000283051.1 ENSMUSG00000127565 (from geneSymbol) uc333nhi.1 uc333nhi.1 
ENSMUST00000283052.1 ENSMUSG00000127566 ENSMUST00000283052.1 ENSMUSG00000127566 (from geneSymbol) uc333nhj.1 uc333nhj.1 
ENSMUST00000283055.1 ENSMUSG00000127567 ENSMUST00000283055.1 ENSMUSG00000127567 (from geneSymbol) uc333nhm.1 uc333nhm.1 
ENSMUST00000283056.1 ENSMUSG00000127568 ENSMUST00000283056.1 ENSMUSG00000127568 (from geneSymbol) uc333nhn.1 uc333nhn.1 
ENSMUST00000283057.1 ENSMUSG00000127569 ENSMUST00000283057.1 ENSMUSG00000127569 (from geneSymbol) uc333nho.1 uc333nho.1 
ENSMUST00000283058.1 9430097D07Rik ENSMUST00000283058.1 9430097D07Rik (from geneSymbol) uc333nhp.1 uc333nhp.1 
ENSMUST00000283060.1 ENSMUSG00000127570 ENSMUST00000283060.1 ENSMUSG00000127570 (from geneSymbol) uc333nhr.1 uc333nhr.1 
ENSMUST00000283081.1 ENSMUSG00000127571 ENSMUST00000283081.1 ENSMUSG00000127571 (from geneSymbol) uc333nim.1 uc333nim.1 
ENSMUST00000283086.1 Gm12709 ENSMUST00000283086.1 Gm12709 (from geneSymbol) AK038336 uc333nir.1 uc333nir.1 
ENSMUST00000283087.1 ENSMUSG00000127572 ENSMUST00000283087.1 ENSMUSG00000127572 (from geneSymbol) uc333nis.1 uc333nis.1 
ENSMUST00000283088.1 ENSMUSG00000127573 ENSMUST00000283088.1 ENSMUSG00000127573 (from geneSymbol) uc333nit.1 uc333nit.1 
ENSMUST00000283090.1 ENSMUSG00000127574 ENSMUST00000283090.1 ENSMUSG00000127574 (from geneSymbol) uc333niv.1 uc333niv.1 
ENSMUST00000283091.1 ENSMUSG00000127575 ENSMUST00000283091.1 ENSMUSG00000127575 (from geneSymbol) uc333niw.1 uc333niw.1 
ENSMUST00000283093.1 ENSMUSG00000127577 ENSMUST00000283093.1 ENSMUSG00000127577 (from geneSymbol) uc333nix.1 uc333nix.1 
ENSMUST00000283096.1 ENSMUSG00000127579 ENSMUST00000283096.1 ENSMUSG00000127579 (from geneSymbol) uc333niz.1 uc333niz.1 
ENSMUST00000283097.1 ENSMUSG00000127580 ENSMUST00000283097.1 ENSMUSG00000127580 (from geneSymbol) uc333nja.1 uc333nja.1 
ENSMUST00000283099.1 ENSMUSG00000127581 ENSMUST00000283099.1 ENSMUSG00000127581 (from geneSymbol) uc333njc.1 uc333njc.1 
ENSMUST00000283101.1 ENSMUSG00000127582 ENSMUST00000283101.1 ENSMUSG00000127582 (from geneSymbol) uc333nje.1 uc333nje.1 
ENSMUST00000283103.1 Gm35037 ENSMUST00000283103.1 Gm35037 (from geneSymbol) uc333njg.1 uc333njg.1 
ENSMUST00000283104.1 ENSMUSG00000127583 ENSMUST00000283104.1 ENSMUSG00000127583 (from geneSymbol) uc333njh.1 uc333njh.1 
ENSMUST00000283105.1 ENSMUSG00000127584 ENSMUST00000283105.1 ENSMUSG00000127584 (from geneSymbol) uc333nji.1 uc333nji.1 
ENSMUST00000283110.1 ENSMUSG00000127585 ENSMUST00000283110.1 ENSMUSG00000127585 (from geneSymbol) uc333njn.1 uc333njn.1 
ENSMUST00000283119.1 Gm41505 ENSMUST00000283119.1 Gm41505 (from geneSymbol) AK142264 uc333njw.1 uc333njw.1 
ENSMUST00000283163.1 ENSMUSG00000127586 ENSMUST00000283163.1 ENSMUSG00000127586 (from geneSymbol) uc333nlo.1 uc333nlo.1 
ENSMUST00000283164.1 ENSMUSG00000127587 ENSMUST00000283164.1 ENSMUSG00000127587 (from geneSymbol) uc333nlp.1 uc333nlp.1 
ENSMUST00000283165.1 ENSMUSG00000127588 ENSMUST00000283165.1 ENSMUSG00000127588 (from geneSymbol) uc333nlq.1 uc333nlq.1 
ENSMUST00000283168.1 ENSMUSG00000127589 ENSMUST00000283168.1 ENSMUSG00000127589 (from geneSymbol) uc333nlt.1 uc333nlt.1 
ENSMUST00000283169.1 ENSMUSG00000127590 ENSMUST00000283169.1 ENSMUSG00000127590 (from geneSymbol) uc333nlu.1 uc333nlu.1 
ENSMUST00000283174.1 ENSMUSG00000127591 ENSMUST00000283174.1 ENSMUSG00000127591 (from geneSymbol) uc333nly.1 uc333nly.1 
ENSMUST00000283175.1 ENSMUSG00000127592 ENSMUST00000283175.1 ENSMUSG00000127592 (from geneSymbol) LF195318 uc333nlz.1 uc333nlz.1 
ENSMUST00000283176.1 ENSMUSG00000127593 ENSMUST00000283176.1 ENSMUSG00000127593 (from geneSymbol) uc333nma.1 uc333nma.1 
ENSMUST00000283178.1 ENSMUSG00000127594 ENSMUST00000283178.1 ENSMUSG00000127594 (from geneSymbol) uc333nmc.1 uc333nmc.1 
ENSMUST00000283180.1 ENSMUSG00000127595 ENSMUST00000283180.1 ENSMUSG00000127595 (from geneSymbol) uc333nme.1 uc333nme.1 
ENSMUST00000283181.1 Gm567 ENSMUST00000283181.1 Gm567 (from geneSymbol) uc333nmf.1 uc333nmf.1 
ENSMUST00000283185.1 ENSMUSG00000127596 ENSMUST00000283185.1 ENSMUSG00000127596 (from geneSymbol) uc333nmj.1 uc333nmj.1 
ENSMUST00000283186.1 ENSMUSG00000127597 ENSMUST00000283186.1 ENSMUSG00000127597 (from geneSymbol) uc333nmk.1 uc333nmk.1 
ENSMUST00000283195.1 ENSMUSG00000127598 ENSMUST00000283195.1 ENSMUSG00000127598 (from geneSymbol) uc333nmt.1 uc333nmt.1 
ENSMUST00000283196.1 ENSMUSG00000127599 ENSMUST00000283196.1 ENSMUSG00000127599 (from geneSymbol) uc333nmu.1 uc333nmu.1 
ENSMUST00000283197.1 ENSMUSG00000127600 ENSMUST00000283197.1 ENSMUSG00000127600 (from geneSymbol) uc333nmv.1 uc333nmv.1 
ENSMUST00000283199.1 ENSMUSG00000127601 ENSMUST00000283199.1 ENSMUSG00000127601 (from geneSymbol) uc333nmx.1 uc333nmx.1 
ENSMUST00000283200.1 Myadml2os ENSMUST00000283200.1 Myadml2os (from geneSymbol) uc333nmy.1 uc333nmy.1 
ENSMUST00000283204.1 ENSMUSG00000127602 ENSMUST00000283204.1 ENSMUSG00000127602 (from geneSymbol) uc333nnc.1 uc333nnc.1 
ENSMUST00000283205.1 ENSMUSG00000127603 ENSMUST00000283205.1 ENSMUSG00000127603 (from geneSymbol) uc333nnd.1 uc333nnd.1 
ENSMUST00000283208.1 ENSMUSG00000127604 ENSMUST00000283208.1 ENSMUSG00000127604 (from geneSymbol) uc333nng.1 uc333nng.1 
ENSMUST00000283212.1 ENSMUSG00000127605 ENSMUST00000283212.1 ENSMUSG00000127605 (from geneSymbol) LF200358 uc333nnk.1 uc333nnk.1 
ENSMUST00000283213.1 ENSMUSG00000127606 ENSMUST00000283213.1 ENSMUSG00000127606 (from geneSymbol) uc333nnl.1 uc333nnl.1 
ENSMUST00000283215.1 ENSMUSG00000127607 ENSMUST00000283215.1 ENSMUSG00000127607 (from geneSymbol) uc333nnn.1 uc333nnn.1 
ENSMUST00000283216.1 ENSMUSG00000127608 ENSMUST00000283216.1 ENSMUSG00000127608 (from geneSymbol) uc333nno.1 uc333nno.1 
ENSMUST00000283217.1 Gm16096 ENSMUST00000283217.1 Gm16096 (from geneSymbol) AK089373 uc333nnp.1 uc333nnp.1 
ENSMUST00000283221.1 ENSMUSG00000127609 ENSMUST00000283221.1 ENSMUSG00000127609 (from geneSymbol) uc333nnt.1 uc333nnt.1 
ENSMUST00000283228.1 ENSMUSG00000127610 ENSMUST00000283228.1 ENSMUSG00000127610 (from geneSymbol) uc333noa.1 uc333noa.1 
ENSMUST00000283232.1 ENSMUSG00000127611 ENSMUST00000283232.1 ENSMUSG00000127611 (from geneSymbol) uc333noe.1 uc333noe.1 
ENSMUST00000283234.1 ENSMUSG00000127612 ENSMUST00000283234.1 ENSMUSG00000127612 (from geneSymbol) uc333nog.1 uc333nog.1 
ENSMUST00000283237.1 ENSMUSG00000127613 ENSMUST00000283237.1 ENSMUSG00000127613 (from geneSymbol) uc333noj.1 uc333noj.1 
ENSMUST00000283247.1 ENSMUSG00000127615 ENSMUST00000283247.1 ENSMUSG00000127615 (from geneSymbol) uc333nos.1 uc333nos.1 
ENSMUST00000283249.1 4930528D03Rik ENSMUST00000283249.1 4930528D03Rik (from geneSymbol) uc333nou.1 uc333nou.1 
ENSMUST00000283263.1 ENSMUSG00000127616 ENSMUST00000283263.1 ENSMUSG00000127616 (from geneSymbol) uc333npi.1 uc333npi.1 
ENSMUST00000283264.1 ENSMUSG00000127617 ENSMUST00000283264.1 ENSMUSG00000127617 (from geneSymbol) uc333npj.1 uc333npj.1 
ENSMUST00000283265.1 ENSMUSG00000127618 ENSMUST00000283265.1 ENSMUSG00000127618 (from geneSymbol) uc333npk.1 uc333npk.1 
ENSMUST00000283267.1 ENSMUSG00000127619 ENSMUST00000283267.1 ENSMUSG00000127619 (from geneSymbol) uc333npm.1 uc333npm.1 
ENSMUST00000283268.1 ENSMUSG00000127620 ENSMUST00000283268.1 ENSMUSG00000127620 (from geneSymbol) uc333npn.1 uc333npn.1 
ENSMUST00000283271.1 ENSMUSG00000127621 ENSMUST00000283271.1 ENSMUSG00000127621 (from geneSymbol) BC064077 uc333npq.1 uc333npq.1 
ENSMUST00000283276.1 ENSMUSG00000127622 ENSMUST00000283276.1 ENSMUSG00000127622 (from geneSymbol) uc333npv.1 uc333npv.1 
ENSMUST00000283280.1 ENSMUSG00000127623 ENSMUST00000283280.1 ENSMUSG00000127623 (from geneSymbol) uc333npz.1 uc333npz.1 
ENSMUST00000283281.1 ENSMUSG00000127624 ENSMUST00000283281.1 ENSMUSG00000127624 (from geneSymbol) uc333nqa.1 uc333nqa.1 
ENSMUST00000283282.1 ENSMUSG00000127625 ENSMUST00000283282.1 ENSMUSG00000127625 (from geneSymbol) uc333nqb.1 uc333nqb.1 
ENSMUST00000283283.1 ENSMUSG00000127626 ENSMUST00000283283.1 ENSMUSG00000127626 (from geneSymbol) uc333nqc.1 uc333nqc.1 
ENSMUST00000283297.1 ENSMUSG00000127627 ENSMUST00000283297.1 ENSMUSG00000127627 (from geneSymbol) uc333nqq.1 uc333nqq.1 
ENSMUST00000283299.1 Gm57351 ENSMUST00000283299.1 Gm57351 (from geneSymbol) uc333nqr.1 uc333nqr.1 
ENSMUST00000283300.1 ENSMUSG00000127629 ENSMUST00000283300.1 ENSMUSG00000127629 (from geneSymbol) uc333nqs.1 uc333nqs.1 
ENSMUST00000283303.1 ENSMUSG00000127630 ENSMUST00000283303.1 ENSMUSG00000127630 (from geneSymbol) uc333nqt.1 uc333nqt.1 
ENSMUST00000283309.1 Gm47143 ENSMUST00000283309.1 Gm47143 (from geneSymbol) uc333nqz.1 uc333nqz.1 
ENSMUST00000283314.1 ENSMUSG00000127631 ENSMUST00000283314.1 ENSMUSG00000127631 (from geneSymbol) uc333nre.1 uc333nre.1 
ENSMUST00000283319.1 ENSMUSG00000127632 ENSMUST00000283319.1 ENSMUSG00000127632 (from geneSymbol) uc333nrj.1 uc333nrj.1 
ENSMUST00000283320.1 ENSMUSG00000127633 ENSMUST00000283320.1 ENSMUSG00000127633 (from geneSymbol) uc333nrk.1 uc333nrk.1 
ENSMUST00000283323.1 ENSMUSG00000127634 ENSMUST00000283323.1 ENSMUSG00000127634 (from geneSymbol) uc333nrn.1 uc333nrn.1 
ENSMUST00000283325.1 ENSMUSG00000127635 ENSMUST00000283325.1 ENSMUSG00000127635 (from geneSymbol) uc333nrp.1 uc333nrp.1 
ENSMUST00000283328.1 ENSMUSG00000127637 ENSMUST00000283328.1 ENSMUSG00000127637 (from geneSymbol) uc333nrr.1 uc333nrr.1 
ENSMUST00000283334.1 ENSMUSG00000127638 ENSMUST00000283334.1 ENSMUSG00000127638 (from geneSymbol) uc333nrx.1 uc333nrx.1 
ENSMUST00000283337.1 ENSMUSG00000127639 ENSMUST00000283337.1 ENSMUSG00000127639 (from geneSymbol) uc333nsa.1 uc333nsa.1 
ENSMUST00000283339.1 ENSMUSG00000127640 ENSMUST00000283339.1 ENSMUSG00000127640 (from geneSymbol) uc333nsc.1 uc333nsc.1 
ENSMUST00000283351.1 ENSMUSG00000127641 ENSMUST00000283351.1 ENSMUSG00000127641 (from geneSymbol) uc333nso.1 uc333nso.1 
ENSMUST00000283352.1 Gm568 ENSMUST00000283352.1 Gm568 (from geneSymbol) BC028561 uc333nsp.1 uc333nsp.1 
ENSMUST00000283353.1 ENSMUSG00000127642 ENSMUST00000283353.1 ENSMUSG00000127642 (from geneSymbol) uc333nsq.1 uc333nsq.1 
ENSMUST00000283354.1 ENSMUSG00000127643 ENSMUST00000283354.1 ENSMUSG00000127643 (from geneSymbol) uc333nsr.1 uc333nsr.1 
ENSMUST00000283355.1 ENSMUSG00000127644 ENSMUST00000283355.1 ENSMUSG00000127644 (from geneSymbol) uc333nss.1 uc333nss.1 
ENSMUST00000283357.1 Gm45620 ENSMUST00000283357.1 Gm45620 (from geneSymbol) uc333nsu.1 uc333nsu.1 
ENSMUST00000283361.1 ENSMUSG00000127645 ENSMUST00000283361.1 ENSMUSG00000127645 (from geneSymbol) uc333nsy.1 uc333nsy.1 
ENSMUST00000283362.1 ENSMUSG00000127646 ENSMUST00000283362.1 ENSMUSG00000127646 (from geneSymbol) uc333nsz.1 uc333nsz.1 
ENSMUST00000283364.1 ENSMUSG00000127647 ENSMUST00000283364.1 ENSMUSG00000127647 (from geneSymbol) uc333ntb.1 uc333ntb.1 
ENSMUST00000283366.1 ENSMUSG00000127648 ENSMUST00000283366.1 ENSMUSG00000127648 (from geneSymbol) uc333ntd.1 uc333ntd.1 
ENSMUST00000283367.1 ENSMUSG00000127649 ENSMUST00000283367.1 ENSMUSG00000127649 (from geneSymbol) uc333nte.1 uc333nte.1 
ENSMUST00000283368.1 ENSMUSG00000127650 ENSMUST00000283368.1 ENSMUSG00000127650 (from geneSymbol) uc333ntf.1 uc333ntf.1 
ENSMUST00000283369.1 ENSMUSG00000127651 ENSMUST00000283369.1 ENSMUSG00000127651 (from geneSymbol) uc333ntg.1 uc333ntg.1 
ENSMUST00000283370.1 ENSMUSG00000127652 ENSMUST00000283370.1 ENSMUSG00000127652 (from geneSymbol) uc333nth.1 uc333nth.1 
ENSMUST00000283371.1 ENSMUSG00000127653 ENSMUST00000283371.1 ENSMUSG00000127653 (from geneSymbol) uc333nti.1 uc333nti.1 
ENSMUST00000283423.1 ENSMUSG00000127655 ENSMUST00000283423.1 ENSMUSG00000127655 (from geneSymbol) uc333ntj.1 uc333ntj.1 
ENSMUST00000283425.1 ENSMUSG00000127656 ENSMUST00000283425.1 ENSMUSG00000127656 (from geneSymbol) uc333ntl.1 uc333ntl.1 
ENSMUST00000283432.1 ENSMUSG00000127657 ENSMUST00000283432.1 ENSMUSG00000127657 (from geneSymbol) uc333nts.1 uc333nts.1 
ENSMUST00000283433.1 ENSMUSG00000127658 ENSMUST00000283433.1 ENSMUSG00000127658 (from geneSymbol) uc333ntt.1 uc333ntt.1 
ENSMUST00000283434.1 Gm13874 ENSMUST00000283434.1 Gm13874 (from geneSymbol) uc333ntu.1 uc333ntu.1 
ENSMUST00000283439.1 ENSMUSG00000127659 ENSMUST00000283439.1 ENSMUSG00000127659 (from geneSymbol) uc333ntz.1 uc333ntz.1 
ENSMUST00000283476.1 ENSMUSG00000127660 ENSMUST00000283476.1 ENSMUSG00000127660 (from geneSymbol) uc333nvk.1 uc333nvk.1 
ENSMUST00000283478.1 ENSMUSG00000127661 ENSMUST00000283478.1 ENSMUSG00000127661 (from geneSymbol) uc333nvm.1 uc333nvm.1 
ENSMUST00000283479.1 ENSMUSG00000127662 ENSMUST00000283479.1 ENSMUSG00000127662 (from geneSymbol) uc333nvn.1 uc333nvn.1 
ENSMUST00000283480.1 ENSMUSG00000127663 ENSMUST00000283480.1 ENSMUSG00000127663 (from geneSymbol) uc333nvo.1 uc333nvo.1 
ENSMUST00000283485.1 ENSMUSG00000127665 ENSMUST00000283485.1 ENSMUSG00000127665 (from geneSymbol) uc333nvs.1 uc333nvs.1 
ENSMUST00000283489.1 ENSMUSG00000127666 ENSMUST00000283489.1 ENSMUSG00000127666 (from geneSymbol) uc333nvw.1 uc333nvw.1 
ENSMUST00000283492.1 ENSMUSG00000127667 ENSMUST00000283492.1 ENSMUSG00000127667 (from geneSymbol) uc333nvz.1 uc333nvz.1 
ENSMUST00000283493.1 ENSMUSG00000127668 ENSMUST00000283493.1 ENSMUSG00000127668 (from geneSymbol) uc333nwa.1 uc333nwa.1 
ENSMUST00000283495.1 ENSMUSG00000127669 ENSMUST00000283495.1 ENSMUSG00000127669 (from geneSymbol) uc333nwc.1 uc333nwc.1 
ENSMUST00000283497.1 ENSMUSG00000127670 ENSMUST00000283497.1 ENSMUSG00000127670 (from geneSymbol) uc333nwe.1 uc333nwe.1 
ENSMUST00000283499.1 ENSMUSG00000127671 ENSMUST00000283499.1 ENSMUSG00000127671 (from geneSymbol) uc333nwg.1 uc333nwg.1 
ENSMUST00000283500.1 ENSMUSG00000127672 ENSMUST00000283500.1 ENSMUSG00000127672 (from geneSymbol) uc333nwh.1 uc333nwh.1 
ENSMUST00000283501.1 ENSMUSG00000127673 ENSMUST00000283501.1 ENSMUSG00000127673 (from geneSymbol) uc333nwi.1 uc333nwi.1 
ENSMUST00000283502.1 ENSMUSG00000127674 ENSMUST00000283502.1 ENSMUSG00000127674 (from geneSymbol) uc333nwj.1 uc333nwj.1 
ENSMUST00000283505.1 ENSMUSG00000127675 ENSMUST00000283505.1 ENSMUSG00000127675 (from geneSymbol) uc333nwm.1 uc333nwm.1 
ENSMUST00000283506.1 ENSMUSG00000127676 ENSMUST00000283506.1 ENSMUSG00000127676 (from geneSymbol) uc333nwn.1 uc333nwn.1 
ENSMUST00000283507.1 ENSMUSG00000127677 ENSMUST00000283507.1 ENSMUSG00000127677 (from geneSymbol) uc333nwo.1 uc333nwo.1 
ENSMUST00000283509.1 ENSMUSG00000127678 ENSMUST00000283509.1 ENSMUSG00000127678 (from geneSymbol) uc333nwq.1 uc333nwq.1 
ENSMUST00000283512.1 ENSMUSG00000127679 ENSMUST00000283512.1 ENSMUSG00000127679 (from geneSymbol) uc333nwt.1 uc333nwt.1 
ENSMUST00000283513.1 ENSMUSG00000127680 ENSMUST00000283513.1 ENSMUSG00000127680 (from geneSymbol) uc333nwu.1 uc333nwu.1 
ENSMUST00000283515.1 ENSMUSG00000127681 ENSMUST00000283515.1 ENSMUSG00000127681 (from geneSymbol) uc333nww.1 uc333nww.1 
ENSMUST00000283523.1 ENSMUSG00000127682 ENSMUST00000283523.1 ENSMUSG00000127682 (from geneSymbol) uc333nxe.1 uc333nxe.1 
ENSMUST00000283525.1 Gm35520 ENSMUST00000283525.1 Gm35520 (from geneSymbol) uc333nxg.1 uc333nxg.1 
ENSMUST00000283549.1 ENSMUSG00000127683 ENSMUST00000283549.1 ENSMUSG00000127683 (from geneSymbol) uc333nye.1 uc333nye.1 
ENSMUST00000283550.1 ENSMUSG00000127684 ENSMUST00000283550.1 ENSMUSG00000127684 (from geneSymbol) uc333nyf.1 uc333nyf.1 
ENSMUST00000283551.1 ENSMUSG00000127685 ENSMUST00000283551.1 ENSMUSG00000127685 (from geneSymbol) uc333nyg.1 uc333nyg.1 
ENSMUST00000283558.1 Gm32589 ENSMUST00000283558.1 Gm32589 (from geneSymbol) uc333nyn.1 uc333nyn.1 
ENSMUST00000283566.1 ENSMUSG00000127687 ENSMUST00000283566.1 ENSMUSG00000127687 (from geneSymbol) uc333nyv.1 uc333nyv.1 
ENSMUST00000283569.1 ENSMUSG00000127688 ENSMUST00000283569.1 ENSMUSG00000127688 (from geneSymbol) uc333nyy.1 uc333nyy.1 
ENSMUST00000283571.1 ENSMUSG00000127689 ENSMUST00000283571.1 ENSMUSG00000127689 (from geneSymbol) uc333nza.1 uc333nza.1 
ENSMUST00000283576.1 Gm35835 ENSMUST00000283576.1 Gm35835 (from geneSymbol) AK132154 uc333nzf.1 uc333nzf.1 
ENSMUST00000283636.1 ENSMUSG00000127690 ENSMUST00000283636.1 ENSMUSG00000127690 (from geneSymbol) uc333obn.1 uc333obn.1 
ENSMUST00000283639.1 ENSMUSG00000127691 ENSMUST00000283639.1 ENSMUSG00000127691 (from geneSymbol) uc333obq.1 uc333obq.1 
ENSMUST00000283651.1 ENSMUSG00000127692 ENSMUST00000283651.1 ENSMUSG00000127692 (from geneSymbol) uc333occ.1 uc333occ.1 
ENSMUST00000283653.1 ENSMUSG00000127693 ENSMUST00000283653.1 ENSMUSG00000127693 (from geneSymbol) uc333oce.1 uc333oce.1 
ENSMUST00000283657.1 ENSMUSG00000127694 ENSMUST00000283657.1 ENSMUSG00000127694 (from geneSymbol) uc333oci.1 uc333oci.1 
ENSMUST00000283658.1 ENSMUSG00000127695 ENSMUST00000283658.1 ENSMUSG00000127695 (from geneSymbol) uc333ocj.1 uc333ocj.1 
ENSMUST00000283659.1 ENSMUSG00000127696 ENSMUST00000283659.1 ENSMUSG00000127696 (from geneSymbol) uc333ock.1 uc333ock.1 
ENSMUST00000283661.1 ENSMUSG00000127697 ENSMUST00000283661.1 ENSMUSG00000127697 (from geneSymbol) uc333ocm.1 uc333ocm.1 
ENSMUST00000283667.1 ENSMUSG00000127698 ENSMUST00000283667.1 ENSMUSG00000127698 (from geneSymbol) uc333ocs.1 uc333ocs.1 
ENSMUST00000283668.1 ENSMUSG00000127699 ENSMUST00000283668.1 ENSMUSG00000127699 (from geneSymbol) uc333oct.1 uc333oct.1 
ENSMUST00000283669.1 Gm40392 ENSMUST00000283669.1 Gm40392 (from geneSymbol) uc333ocu.1 uc333ocu.1 
ENSMUST00000283670.1 ENSMUSG00000127700 ENSMUST00000283670.1 ENSMUSG00000127700 (from geneSymbol) uc333ocv.1 uc333ocv.1 
ENSMUST00000283671.1 ENSMUSG00000127701 ENSMUST00000283671.1 ENSMUSG00000127701 (from geneSymbol) uc333ocw.1 uc333ocw.1 
ENSMUST00000283672.1 ENSMUSG00000127702 ENSMUST00000283672.1 ENSMUSG00000127702 (from geneSymbol) uc333ocx.1 uc333ocx.1 
ENSMUST00000283676.1 ENSMUSG00000127703 ENSMUST00000283676.1 ENSMUSG00000127703 (from geneSymbol) uc333oda.1 uc333oda.1 
ENSMUST00000283677.1 ENSMUSG00000127704 ENSMUST00000283677.1 ENSMUSG00000127704 (from geneSymbol) uc333odb.1 uc333odb.1 
ENSMUST00000283678.1 ENSMUSG00000127705 ENSMUST00000283678.1 ENSMUSG00000127705 (from geneSymbol) uc333odc.1 uc333odc.1 
ENSMUST00000283679.1 ENSMUSG00000127706 ENSMUST00000283679.1 ENSMUSG00000127706 (from geneSymbol) uc333odd.1 uc333odd.1 
ENSMUST00000283680.1 ENSMUSG00000127707 ENSMUST00000283680.1 ENSMUSG00000127707 (from geneSymbol) uc333ode.1 uc333ode.1 
ENSMUST00000283681.1 ENSMUSG00000127708 ENSMUST00000283681.1 ENSMUSG00000127708 (from geneSymbol) uc333odf.1 uc333odf.1 
ENSMUST00000283683.1 ENSMUSG00000127709 ENSMUST00000283683.1 ENSMUSG00000127709 (from geneSymbol) uc333odh.1 uc333odh.1 
ENSMUST00000283687.1 ENSMUSG00000127710 ENSMUST00000283687.1 ENSMUSG00000127710 (from geneSymbol) uc333odl.1 uc333odl.1 
ENSMUST00000283689.1 ENSMUSG00000127711 ENSMUST00000283689.1 ENSMUSG00000127711 (from geneSymbol) uc333odn.1 uc333odn.1 
ENSMUST00000283694.1 Gm17333 ENSMUST00000283694.1 Gm17333 (from geneSymbol) EU234022 uc333ods.1 uc333ods.1 
ENSMUST00000283697.1 ENSMUSG00000127712 ENSMUST00000283697.1 ENSMUSG00000127712 (from geneSymbol) uc333odv.1 uc333odv.1 
ENSMUST00000283701.1 ENSMUSG00000127713 ENSMUST00000283701.1 ENSMUSG00000127713 (from geneSymbol) uc333odz.1 uc333odz.1 
ENSMUST00000283702.1 ENSMUSG00000127714 ENSMUST00000283702.1 ENSMUSG00000127714 (from geneSymbol) uc333oea.1 uc333oea.1 
ENSMUST00000283703.1 ENSMUSG00000127715 ENSMUST00000283703.1 ENSMUSG00000127715 (from geneSymbol) uc333oeb.1 uc333oeb.1 
ENSMUST00000283704.1 Gm31630 ENSMUST00000283704.1 Gm31630 (from geneSymbol) AK132727 uc333oec.1 uc333oec.1 
ENSMUST00000283709.1 ENSMUSG00000127716 ENSMUST00000283709.1 ENSMUSG00000127716 (from geneSymbol) uc333oeh.1 uc333oeh.1 
ENSMUST00000283711.1 ENSMUSG00000127717 ENSMUST00000283711.1 ENSMUSG00000127717 (from geneSymbol) uc333oej.1 uc333oej.1 
ENSMUST00000283712.1 ENSMUSG00000127718 ENSMUST00000283712.1 ENSMUSG00000127718 (from geneSymbol) uc333oek.1 uc333oek.1 
ENSMUST00000283715.1 ENSMUSG00000127719 ENSMUST00000283715.1 ENSMUSG00000127719 (from geneSymbol) uc333oen.1 uc333oen.1 
ENSMUST00000283728.1 ENSMUSG00000127720 ENSMUST00000283728.1 ENSMUSG00000127720 (from geneSymbol) uc333ofa.1 uc333ofa.1 
ENSMUST00000283729.1 ENSMUSG00000127721 ENSMUST00000283729.1 ENSMUSG00000127721 (from geneSymbol) uc333ofb.1 uc333ofb.1 
ENSMUST00000283730.1 ENSMUSG00000121794 ENSMUST00000283730.1 ENSMUSG00000121794 (from geneSymbol) uc333ofc.1 uc333ofc.1 
ENSMUST00000283733.1 ENSMUSG00000127722 ENSMUST00000283733.1 ENSMUSG00000127722 (from geneSymbol) uc333off.1 uc333off.1 
ENSMUST00000283734.1 1500002C15Rik ENSMUST00000283734.1 1500002C15Rik (from geneSymbol) uc333ofg.1 uc333ofg.1 
ENSMUST00000283742.1 ENSMUSG00000127723 ENSMUST00000283742.1 ENSMUSG00000127723 (from geneSymbol) uc333ofo.1 uc333ofo.1 
ENSMUST00000283744.1 ENSMUSG00000127724 ENSMUST00000283744.1 ENSMUSG00000127724 (from geneSymbol) uc333ofq.1 uc333ofq.1 
ENSMUST00000283754.1 ENSMUSG00000127725 ENSMUST00000283754.1 ENSMUSG00000127725 (from geneSymbol) uc333oga.1 uc333oga.1 
ENSMUST00000283755.1 ENSMUSG00000127726 ENSMUST00000283755.1 ENSMUSG00000127726 (from geneSymbol) uc333ogb.1 uc333ogb.1 
ENSMUST00000283758.1 ENSMUSG00000127727 ENSMUST00000283758.1 ENSMUSG00000127727 (from geneSymbol) uc333oge.1 uc333oge.1 
ENSMUST00000283760.1 ENSMUSG00000127728 ENSMUST00000283760.1 ENSMUSG00000127728 (from geneSymbol) uc333ogg.1 uc333ogg.1 
ENSMUST00000283763.1 ENSMUSG00000127729 ENSMUST00000283763.1 ENSMUSG00000127729 (from geneSymbol) uc333ogj.1 uc333ogj.1 
ENSMUST00000283764.1 ENSMUSG00000127730 ENSMUST00000283764.1 ENSMUSG00000127730 (from geneSymbol) uc333ogk.1 uc333ogk.1 
ENSMUST00000283765.1 ENSMUSG00000127731 ENSMUST00000283765.1 ENSMUSG00000127731 (from geneSymbol) uc333ogl.1 uc333ogl.1 
ENSMUST00000283766.1 ENSMUSG00000127732 ENSMUST00000283766.1 ENSMUSG00000127732 (from geneSymbol) uc333ogm.1 uc333ogm.1 
ENSMUST00000283771.1 ENSMUSG00000127733 ENSMUST00000283771.1 ENSMUSG00000127733 (from geneSymbol) uc333ogr.1 uc333ogr.1 
ENSMUST00000283773.1 ENSMUSG00000127734 ENSMUST00000283773.1 ENSMUSG00000127734 (from geneSymbol) uc333ogt.1 uc333ogt.1 
ENSMUST00000283775.1 ENSMUSG00000127735 ENSMUST00000283775.1 ENSMUSG00000127735 (from geneSymbol) uc333ogv.1 uc333ogv.1 
ENSMUST00000283777.1 ENSMUSG00000127736 ENSMUST00000283777.1 ENSMUSG00000127736 (from geneSymbol) L04852 uc333ogx.1 uc333ogx.1 
ENSMUST00000283778.1 ENSMUSG00000127737 ENSMUST00000283778.1 ENSMUSG00000127737 (from geneSymbol) uc333ogy.1 uc333ogy.1 
ENSMUST00000283779.1 ENSMUSG00000127738 ENSMUST00000283779.1 ENSMUSG00000127738 (from geneSymbol) uc333ogz.1 uc333ogz.1 
ENSMUST00000283781.1 ENSMUSG00000127739 ENSMUST00000283781.1 ENSMUSG00000127739 (from geneSymbol) uc333ohb.1 uc333ohb.1 
ENSMUST00000283784.1 ENSMUSG00000127740 ENSMUST00000283784.1 ENSMUSG00000127740 (from geneSymbol) uc333ohe.1 uc333ohe.1 
ENSMUST00000283802.1 ENSMUSG00000127741 ENSMUST00000283802.1 ENSMUSG00000127741 (from geneSymbol) uc333ohw.1 uc333ohw.1 
ENSMUST00000283803.1 ENSMUSG00000127742 ENSMUST00000283803.1 ENSMUSG00000127742 (from geneSymbol) uc333ohx.1 uc333ohx.1 
ENSMUST00000283809.1 ENSMUSG00000127743 ENSMUST00000283809.1 ENSMUSG00000127743 (from geneSymbol) uc333oid.1 uc333oid.1 
ENSMUST00000283810.1 Gm34215 ENSMUST00000283810.1 Gm34215 (from geneSymbol) uc333oie.1 uc333oie.1 
ENSMUST00000283823.1 ENSMUSG00000127744 ENSMUST00000283823.1 ENSMUSG00000127744 (from geneSymbol) uc333oir.1 uc333oir.1 
ENSMUST00000283824.1 ENSMUSG00000127745 ENSMUST00000283824.1 ENSMUSG00000127745 (from geneSymbol) uc333ois.1 uc333ois.1 
ENSMUST00000283825.1 ENSMUSG00000127746 ENSMUST00000283825.1 ENSMUSG00000127746 (from geneSymbol) uc333oit.1 uc333oit.1 
ENSMUST00000283826.1 ENSMUSG00000127747 ENSMUST00000283826.1 ENSMUSG00000127747 (from geneSymbol) uc333oiu.1 uc333oiu.1 
ENSMUST00000283830.1 0610038B21Rik ENSMUST00000283830.1 0610038B21Rik (from geneSymbol) AK166159 uc333oiy.1 uc333oiy.1 
ENSMUST00000283837.1 ENSMUSG00000127748 ENSMUST00000283837.1 ENSMUSG00000127748 (from geneSymbol) uc333ojf.1 uc333ojf.1 
ENSMUST00000283839.1 ENSMUSG00000127749 ENSMUST00000283839.1 ENSMUSG00000127749 (from geneSymbol) uc333ojh.1 uc333ojh.1 
ENSMUST00000283840.1 ENSMUSG00000127750 ENSMUST00000283840.1 ENSMUSG00000127750 (from geneSymbol) uc333oji.1 uc333oji.1 
ENSMUST00000283842.1 1700010L04Rik ENSMUST00000283842.1 1700010L04Rik (from geneSymbol) AK005840 uc333ojk.1 uc333ojk.1 
ENSMUST00000283860.1 ENSMUSG00000127751 ENSMUST00000283860.1 ENSMUSG00000127751 (from geneSymbol) uc333okb.1 uc333okb.1 
ENSMUST00000283863.1 ENSMUSG00000127752 ENSMUST00000283863.1 ENSMUSG00000127752 (from geneSymbol) uc333oke.1 uc333oke.1 
ENSMUST00000283865.1 ENSMUSG00000127753 ENSMUST00000283865.1 ENSMUSG00000127753 (from geneSymbol) AK143000 uc333okg.1 uc333okg.1 
ENSMUST00000283869.1 ENSMUSG00000127754 ENSMUST00000283869.1 ENSMUSG00000127754 (from geneSymbol) uc333okk.1 uc333okk.1 
ENSMUST00000283872.1 ENSMUSG00000127755 ENSMUST00000283872.1 ENSMUSG00000127755 (from geneSymbol) uc333okn.1 uc333okn.1 
ENSMUST00000283873.1 ENSMUSG00000127756 ENSMUST00000283873.1 ENSMUSG00000127756 (from geneSymbol) uc333oko.1 uc333oko.1 
ENSMUST00000283874.1 ENSMUSG00000127757 ENSMUST00000283874.1 ENSMUSG00000127757 (from geneSymbol) uc333okp.1 uc333okp.1 
ENSMUST00000283875.1 ENSMUSG00000127758 ENSMUST00000283875.1 ENSMUSG00000127758 (from geneSymbol) uc333okq.1 uc333okq.1 
ENSMUST00000283877.1 ENSMUSG00000127759 ENSMUST00000283877.1 ENSMUSG00000127759 (from geneSymbol) uc333oks.1 uc333oks.1 
ENSMUST00000283878.1 ENSMUSG00000127760 ENSMUST00000283878.1 ENSMUSG00000127760 (from geneSymbol) uc333okt.1 uc333okt.1 
ENSMUST00000283882.1 ENSMUSG00000127761 ENSMUST00000283882.1 ENSMUSG00000127761 (from geneSymbol) uc333okx.1 uc333okx.1 
ENSMUST00000283884.1 ENSMUSG00000127762 ENSMUST00000283884.1 ENSMUSG00000127762 (from geneSymbol) uc333okz.1 uc333okz.1 
ENSMUST00000283885.1 ENSMUSG00000127763 ENSMUST00000283885.1 ENSMUSG00000127763 (from geneSymbol) uc333ola.1 uc333ola.1 
ENSMUST00000283886.1 ENSMUSG00000127764 ENSMUST00000283886.1 ENSMUSG00000127764 (from geneSymbol) uc333olb.1 uc333olb.1 
ENSMUST00000283890.1 ENSMUSG00000127765 ENSMUST00000283890.1 ENSMUSG00000127765 (from geneSymbol) uc333olf.1 uc333olf.1 
ENSMUST00000283905.1 ENSMUSG00000127766 ENSMUST00000283905.1 ENSMUSG00000127766 (from geneSymbol) uc333olu.1 uc333olu.1 
ENSMUST00000283913.1 ENSMUSG00000127767 ENSMUST00000283913.1 ENSMUSG00000127767 (from geneSymbol) uc333omc.1 uc333omc.1 
ENSMUST00000283914.1 ENSMUSG00000127768 ENSMUST00000283914.1 ENSMUSG00000127768 (from geneSymbol) uc333omd.1 uc333omd.1 
ENSMUST00000283919.1 ENSMUSG00000127769 ENSMUST00000283919.1 ENSMUSG00000127769 (from geneSymbol) uc333omi.1 uc333omi.1 
ENSMUST00000283921.1 ENSMUSG00000127770 ENSMUST00000283921.1 ENSMUSG00000127770 (from geneSymbol) uc333omk.1 uc333omk.1 
ENSMUST00000283922.1 ENSMUSG00000127771 ENSMUST00000283922.1 ENSMUSG00000127771 (from geneSymbol) uc333oml.1 uc333oml.1 
ENSMUST00000283923.1 ENSMUSG00000127772 ENSMUST00000283923.1 ENSMUSG00000127772 (from geneSymbol) uc333omm.1 uc333omm.1 
ENSMUST00000283924.1 ENSMUSG00000127773 ENSMUST00000283924.1 ENSMUSG00000127773 (from geneSymbol) uc333omn.1 uc333omn.1 
ENSMUST00000283926.1 ENSMUSG00000127774 ENSMUST00000283926.1 ENSMUSG00000127774 (from geneSymbol) uc333omp.1 uc333omp.1 
ENSMUST00000283927.1 ENSMUSG00000127775 ENSMUST00000283927.1 ENSMUSG00000127775 (from geneSymbol) uc333omq.1 uc333omq.1 
ENSMUST00000283928.1 ENSMUSG00000127776 ENSMUST00000283928.1 ENSMUSG00000127776 (from geneSymbol) uc333omr.1 uc333omr.1 
ENSMUST00000283929.1 ENSMUSG00000127777 ENSMUST00000283929.1 ENSMUSG00000127777 (from geneSymbol) uc333oms.1 uc333oms.1 
ENSMUST00000283936.1 ENSMUSG00000127778 ENSMUST00000283936.1 ENSMUSG00000127778 (from geneSymbol) uc333omz.1 uc333omz.1 
ENSMUST00000283939.1 ENSMUSG00000127779 ENSMUST00000283939.1 ENSMUSG00000127779 (from geneSymbol) uc333onc.1 uc333onc.1 
ENSMUST00000283940.1 ENSMUSG00000127780 ENSMUST00000283940.1 ENSMUSG00000127780 (from geneSymbol) uc333ond.1 uc333ond.1 
ENSMUST00000283943.1 ENSMUSG00000127781 ENSMUST00000283943.1 ENSMUSG00000127781 (from geneSymbol) uc333ong.1 uc333ong.1 
ENSMUST00000283944.1 ENSMUSG00000127782 ENSMUST00000283944.1 ENSMUSG00000127782 (from geneSymbol) uc333onh.1 uc333onh.1 
ENSMUST00000283945.1 ENSMUSG00000127783 ENSMUST00000283945.1 ENSMUSG00000127783 (from geneSymbol) uc333oni.1 uc333oni.1 
ENSMUST00000283946.1 ENSMUSG00000127784 ENSMUST00000283946.1 ENSMUSG00000127784 (from geneSymbol) uc333onj.1 uc333onj.1 
ENSMUST00000283948.1 ENSMUSG00000127785 ENSMUST00000283948.1 ENSMUSG00000127785 (from geneSymbol) uc333onl.1 uc333onl.1 
ENSMUST00000283949.1 ENSMUSG00000127786 ENSMUST00000283949.1 ENSMUSG00000127786 (from geneSymbol) uc333onm.1 uc333onm.1 
ENSMUST00000283950.1 ENSMUSG00000127787 ENSMUST00000283950.1 ENSMUSG00000127787 (from geneSymbol) uc333onn.1 uc333onn.1 
ENSMUST00000283951.1 Gm13861 ENSMUST00000283951.1 Gm13861 (from geneSymbol) AK085764 uc333ono.1 uc333ono.1 
ENSMUST00000283954.1 Gm35239 ENSMUST00000283954.1 Gm35239 (from geneSymbol) uc333onr.1 uc333onr.1 
ENSMUST00000283974.1 ENSMUSG00000127788 ENSMUST00000283974.1 ENSMUSG00000127788 (from geneSymbol) uc333ool.1 uc333ool.1 
ENSMUST00000283978.1 ENSMUSG00000127789 ENSMUST00000283978.1 ENSMUSG00000127789 (from geneSymbol) uc333oop.1 uc333oop.1 
ENSMUST00000283981.1 Gm57136 ENSMUST00000283981.1 Gm57136 (from geneSymbol) uc333oos.1 uc333oos.1 
ENSMUST00000283986.1 ENSMUSG00000127791 ENSMUST00000283986.1 ENSMUSG00000127791 (from geneSymbol) uc333oox.1 uc333oox.1 
ENSMUST00000283987.1 ENSMUSG00000127792 ENSMUST00000283987.1 ENSMUSG00000127792 (from geneSymbol) uc333ooy.1 uc333ooy.1 
ENSMUST00000283988.1 ENSMUSG00000127793 ENSMUST00000283988.1 ENSMUSG00000127793 (from geneSymbol) uc333ooz.1 uc333ooz.1 
ENSMUST00000283989.1 ENSMUSG00000127794 ENSMUST00000283989.1 ENSMUSG00000127794 (from geneSymbol) uc333opa.1 uc333opa.1 
ENSMUST00000283996.1 ENSMUSG00000127795 ENSMUST00000283996.1 ENSMUSG00000127795 (from geneSymbol) uc333oph.1 uc333oph.1 
ENSMUST00000283997.1 ENSMUSG00000127796 ENSMUST00000283997.1 ENSMUSG00000127796 (from geneSymbol) uc333opi.1 uc333opi.1 
ENSMUST00000283998.1 Gm26749 ENSMUST00000283998.1 Gm26749 (from geneSymbol) AK015521 uc333opj.1 uc333opj.1 
ENSMUST00000284022.1 ENSMUSG00000127797 ENSMUST00000284022.1 ENSMUSG00000127797 (from geneSymbol) uc333oqh.1 uc333oqh.1 
ENSMUST00000284023.1 ENSMUSG00000127798 ENSMUST00000284023.1 ENSMUSG00000127798 (from geneSymbol) AK031219 uc333oqi.1 uc333oqi.1 
ENSMUST00000284028.1 Gm36584 ENSMUST00000284028.1 Gm36584 (from geneSymbol) AK076849 uc333oqn.1 uc333oqn.1 
ENSMUST00000284062.1 ENSMUSG00000127799 ENSMUST00000284062.1 ENSMUSG00000127799 (from geneSymbol) uc333orv.1 uc333orv.1 
ENSMUST00000284063.1 ENSMUSG00000127800 ENSMUST00000284063.1 ENSMUSG00000127800 (from geneSymbol) uc333orw.1 uc333orw.1 
ENSMUST00000284064.1 ENSMUSG00000127801 ENSMUST00000284064.1 ENSMUSG00000127801 (from geneSymbol) uc333orx.1 uc333orx.1 
ENSMUST00000284065.1 ENSMUSG00000127802 ENSMUST00000284065.1 ENSMUSG00000127802 (from geneSymbol) uc333ory.1 uc333ory.1 
ENSMUST00000284068.1 ENSMUSG00000127803 ENSMUST00000284068.1 ENSMUSG00000127803 (from geneSymbol) uc333osb.1 uc333osb.1 
ENSMUST00000284069.1 4933421A08Rik ENSMUST00000284069.1 4933421A08Rik (from geneSymbol) AK016855 uc333osc.1 uc333osc.1 
ENSMUST00000284073.1 Gm48977 ENSMUST00000284073.1 Gm48977 (from geneSymbol) AK040242 uc333osg.1 uc333osg.1 
ENSMUST00000284074.1 Gm13375 ENSMUST00000284074.1 Gm13375 (from geneSymbol) uc333osh.1 uc333osh.1 
ENSMUST00000284078.1 ENSMUSG00000127805 ENSMUST00000284078.1 ENSMUSG00000127805 (from geneSymbol) uc333osk.1 uc333osk.1 
ENSMUST00000284080.1 ENSMUSG00000127806 ENSMUST00000284080.1 ENSMUSG00000127806 (from geneSymbol) uc333osm.1 uc333osm.1 
ENSMUST00000284086.1 4930593A02Rik ENSMUST00000284086.1 4930593A02Rik (from geneSymbol) AK017132 uc333oss.1 uc333oss.1 
ENSMUST00000284110.1 ENSMUSG00000127807 ENSMUST00000284110.1 ENSMUSG00000127807 (from geneSymbol) uc333otq.1 uc333otq.1 
ENSMUST00000284111.1 ENSMUSG00000127808 ENSMUST00000284111.1 ENSMUSG00000127808 (from geneSymbol) uc333otr.1 uc333otr.1 
ENSMUST00000284112.1 ENSMUSG00000127809 ENSMUST00000284112.1 ENSMUSG00000127809 (from geneSymbol) uc333ots.1 uc333ots.1 
ENSMUST00000284113.1 Gm45488 ENSMUST00000284113.1 Gm45488 (from geneSymbol) uc333ott.1 uc333ott.1 
ENSMUST00000284116.1 ENSMUSG00000127810 ENSMUST00000284116.1 ENSMUSG00000127810 (from geneSymbol) uc333otw.1 uc333otw.1 
ENSMUST00000284118.1 ENSMUSG00000127811 ENSMUST00000284118.1 ENSMUSG00000127811 (from geneSymbol) uc333oty.1 uc333oty.1 
ENSMUST00000284121.1 Gm30808 ENSMUST00000284121.1 Gm30808 (from geneSymbol) uc333oub.1 uc333oub.1 
ENSMUST00000284123.1 ENSMUSG00000127812 ENSMUST00000284123.1 ENSMUSG00000127812 (from geneSymbol) uc333oud.1 uc333oud.1 
ENSMUST00000284125.1 Gm27008 ENSMUST00000284125.1 Gm27008 (from geneSymbol) AK038087 uc333ouf.1 uc333ouf.1 
ENSMUST00000284161.1 ENSMUSG00000127813 ENSMUST00000284161.1 ENSMUSG00000127813 (from geneSymbol) uc333ovp.1 uc333ovp.1 
ENSMUST00000284166.1 ENSMUSG00000127814 ENSMUST00000284166.1 ENSMUSG00000127814 (from geneSymbol) uc333ovu.1 uc333ovu.1 
ENSMUST00000284167.1 ENSMUSG00000127815 ENSMUST00000284167.1 ENSMUSG00000127815 (from geneSymbol) uc333ovv.1 uc333ovv.1 
ENSMUST00000284170.1 ENSMUSG00000127816 ENSMUST00000284170.1 ENSMUSG00000127816 (from geneSymbol) uc333ovy.1 uc333ovy.1 
ENSMUST00000284171.1 ENSMUSG00000127817 ENSMUST00000284171.1 ENSMUSG00000127817 (from geneSymbol) uc333ovz.1 uc333ovz.1 
ENSMUST00000284179.1 1700014L14Rik ENSMUST00000284179.1 1700014L14Rik (from geneSymbol) AK005981 uc333owh.1 uc333owh.1 
ENSMUST00000284186.1 ENSMUSG00000127818 ENSMUST00000284186.1 ENSMUSG00000127818 (from geneSymbol) uc333owo.1 uc333owo.1 
ENSMUST00000284187.1 ENSMUSG00000127819 ENSMUST00000284187.1 ENSMUSG00000127819 (from geneSymbol) uc333owp.1 uc333owp.1 
ENSMUST00000284191.1 ENSMUSG00000127820 ENSMUST00000284191.1 ENSMUSG00000127820 (from geneSymbol) uc333owt.1 uc333owt.1 
ENSMUST00000284192.1 ENSMUSG00000127821 ENSMUST00000284192.1 ENSMUSG00000127821 (from geneSymbol) AK006142 uc333owu.1 uc333owu.1 
ENSMUST00000284193.1 ENSMUSG00000127822 ENSMUST00000284193.1 ENSMUSG00000127822 (from geneSymbol) uc333owv.1 uc333owv.1 
ENSMUST00000284194.1 ENSMUSG00000127823 ENSMUST00000284194.1 ENSMUSG00000127823 (from geneSymbol) uc333oww.1 uc333oww.1 
ENSMUST00000284195.1 ENSMUSG00000127824 ENSMUST00000284195.1 ENSMUSG00000127824 (from geneSymbol) uc333owx.1 uc333owx.1 
ENSMUST00000284202.1 ENSMUSG00000127825 ENSMUST00000284202.1 ENSMUSG00000127825 (from geneSymbol) uc333oxe.1 uc333oxe.1 
ENSMUST00000284210.1 ENSMUSG00000127826 ENSMUST00000284210.1 ENSMUSG00000127826 (from geneSymbol) uc333oxm.1 uc333oxm.1 
ENSMUST00000284211.1 ENSMUSG00000127827 ENSMUST00000284211.1 ENSMUSG00000127827 (from geneSymbol) uc333oxn.1 uc333oxn.1 
ENSMUST00000284220.1 ENSMUSG00000127828 ENSMUST00000284220.1 ENSMUSG00000127828 (from geneSymbol) uc333oxw.1 uc333oxw.1 
ENSMUST00000284226.1 ENSMUSG00000127829 ENSMUST00000284226.1 ENSMUSG00000127829 (from geneSymbol) uc333oyc.1 uc333oyc.1 
ENSMUST00000284227.1 ENSMUSG00000127830 ENSMUST00000284227.1 ENSMUSG00000127830 (from geneSymbol) uc333oyd.1 uc333oyd.1 
ENSMUST00000284229.1 ENSMUSG00000127831 ENSMUST00000284229.1 ENSMUSG00000127831 (from geneSymbol) uc333oyf.1 uc333oyf.1 
ENSMUST00000284230.1 ENSMUSG00000127832 ENSMUST00000284230.1 ENSMUSG00000127832 (from geneSymbol) uc333oyg.1 uc333oyg.1 
ENSMUST00000284233.1 ENSMUSG00000127833 ENSMUST00000284233.1 ENSMUSG00000127833 (from geneSymbol) uc333oyj.1 uc333oyj.1 
ENSMUST00000284234.1 ENSMUSG00000127834 ENSMUST00000284234.1 ENSMUSG00000127834 (from geneSymbol) uc333oyk.1 uc333oyk.1 
ENSMUST00000284235.1 ENSMUSG00000127835 ENSMUST00000284235.1 ENSMUSG00000127835 (from geneSymbol) uc333oyl.1 uc333oyl.1 
ENSMUST00000284250.1 6530401F13Rik ENSMUST00000284250.1 6530401F13Rik (from geneSymbol) uc333oza.1 uc333oza.1 
ENSMUST00000284260.1 4933430H16Rik ENSMUST00000284260.1 RIKEN cDNA 4933430H16 gene (from RefSeq NR_045855.1) NR_045855 uc333ozj.1 uc333ozj.1 
ENSMUST00000284261.1 4930598N05Rik ENSMUST00000284261.1 4930598N05Rik (from geneSymbol) AK016412 uc333ozk.1 uc333ozk.1 
ENSMUST00000284301.1 ENSMUSG00000127837 ENSMUST00000284301.1 ENSMUSG00000127837 (from geneSymbol) uc333pay.1 uc333pay.1 
ENSMUST00000284302.1 ENSMUSG00000127838 ENSMUST00000284302.1 ENSMUSG00000127838 (from geneSymbol) uc333paz.1 uc333paz.1 
ENSMUST00000284303.1 ENSMUSG00000127839 ENSMUST00000284303.1 ENSMUSG00000127839 (from geneSymbol) uc333pba.1 uc333pba.1 
ENSMUST00000284304.1 ENSMUSG00000127840 ENSMUST00000284304.1 ENSMUSG00000127840 (from geneSymbol) uc333pbb.1 uc333pbb.1 
ENSMUST00000284305.1 ENSMUSG00000127841 ENSMUST00000284305.1 ENSMUSG00000127841 (from geneSymbol) uc333pbc.1 uc333pbc.1 
ENSMUST00000284307.1 ENSMUSG00000127842 ENSMUST00000284307.1 ENSMUSG00000127842 (from geneSymbol) uc333pbe.1 uc333pbe.1 
ENSMUST00000284308.1 ENSMUSG00000127843 ENSMUST00000284308.1 ENSMUSG00000127843 (from geneSymbol) uc333pbf.1 uc333pbf.1 
ENSMUST00000284315.1 Gm45027 ENSMUST00000284315.1 Gm45027 (from geneSymbol) uc333pbm.1 uc333pbm.1 
ENSMUST00000284318.1 ENSMUSG00000127844 ENSMUST00000284318.1 ENSMUSG00000127844 (from geneSymbol) uc333pbp.1 uc333pbp.1 
ENSMUST00000284322.1 Gm16118 ENSMUST00000284322.1 Gm16118 (from geneSymbol) uc333pbt.1 uc333pbt.1 
ENSMUST00000284323.1 Gm28783 ENSMUST00000284323.1 Gm28783 (from geneSymbol) uc333pbu.1 uc333pbu.1 
ENSMUST00000284325.1 ENSMUSG00000127845 ENSMUST00000284325.1 ENSMUSG00000127845 (from geneSymbol) uc333pbw.1 uc333pbw.1 
ENSMUST00000284326.1 ENSMUSG00000127846 ENSMUST00000284326.1 ENSMUSG00000127846 (from geneSymbol) uc333pbx.1 uc333pbx.1 
ENSMUST00000284327.1 ENSMUSG00000127847 ENSMUST00000284327.1 ENSMUSG00000127847 (from geneSymbol) uc333pby.1 uc333pby.1 
ENSMUST00000284328.1 ENSMUSG00000127848 ENSMUST00000284328.1 ENSMUSG00000127848 (from geneSymbol) uc333pbz.1 uc333pbz.1 
ENSMUST00000284329.1 ENSMUSG00000127849 ENSMUST00000284329.1 ENSMUSG00000127849 (from geneSymbol) uc333pca.1 uc333pca.1 
ENSMUST00000284332.1 ENSMUSG00000127850 ENSMUST00000284332.1 ENSMUSG00000127850 (from geneSymbol) uc333pcd.1 uc333pcd.1 
ENSMUST00000284334.1 ENSMUSG00000127852 ENSMUST00000284334.1 ENSMUSG00000127852 (from geneSymbol) uc333pce.1 uc333pce.1 
ENSMUST00000284335.1 ENSMUSG00000127853 ENSMUST00000284335.1 ENSMUSG00000127853 (from geneSymbol) uc333pcf.1 uc333pcf.1 
ENSMUST00000284336.1 ENSMUSG00000127854 ENSMUST00000284336.1 ENSMUSG00000127854 (from geneSymbol) uc333pcg.1 uc333pcg.1 
ENSMUST00000284337.1 ENSMUSG00000127855 ENSMUST00000284337.1 ENSMUSG00000127855 (from geneSymbol) uc333pch.1 uc333pch.1 
ENSMUST00000284339.1 ENSMUSG00000127856 ENSMUST00000284339.1 ENSMUSG00000127856 (from geneSymbol) uc333pcj.1 uc333pcj.1 
ENSMUST00000284348.1 ENSMUSG00000127857 ENSMUST00000284348.1 ENSMUSG00000127857 (from geneSymbol) uc333pcs.1 uc333pcs.1 
ENSMUST00000284349.1 ENSMUSG00000127858 ENSMUST00000284349.1 ENSMUSG00000127858 (from geneSymbol) uc333pct.1 uc333pct.1 
ENSMUST00000284351.1 ENSMUSG00000127859 ENSMUST00000284351.1 ENSMUSG00000127859 (from geneSymbol) uc333pcv.1 uc333pcv.1 
ENSMUST00000284352.1 ENSMUSG00000127860 ENSMUST00000284352.1 ENSMUSG00000127860 (from geneSymbol) uc333pcw.1 uc333pcw.1 
ENSMUST00000284354.1 ENSMUSG00000127861 ENSMUST00000284354.1 ENSMUSG00000127861 (from geneSymbol) uc333pcy.1 uc333pcy.1 
ENSMUST00000284359.1 ENSMUSG00000127862 ENSMUST00000284359.1 ENSMUSG00000127862 (from geneSymbol) AK020613 uc333pdd.1 uc333pdd.1 
ENSMUST00000284361.1 ENSMUSG00000127863 ENSMUST00000284361.1 ENSMUSG00000127863 (from geneSymbol) uc333pdf.1 uc333pdf.1 
ENSMUST00000284362.1 ENSMUSG00000127864 ENSMUST00000284362.1 ENSMUSG00000127864 (from geneSymbol) uc333pdg.1 uc333pdg.1 
ENSMUST00000284363.1 ENSMUSG00000127865 ENSMUST00000284363.1 ENSMUSG00000127865 (from geneSymbol) uc333pdh.1 uc333pdh.1 
ENSMUST00000284367.1 ENSMUSG00000127866 ENSMUST00000284367.1 ENSMUSG00000127866 (from geneSymbol) uc333pdl.1 uc333pdl.1 
ENSMUST00000284368.1 ENSMUSG00000127867 ENSMUST00000284368.1 ENSMUSG00000127867 (from geneSymbol) uc333pdm.1 uc333pdm.1 
ENSMUST00000284370.1 ENSMUSG00000127868 ENSMUST00000284370.1 ENSMUSG00000127868 (from geneSymbol) uc333pdo.1 uc333pdo.1 
ENSMUST00000284371.1 ENSMUSG00000127869 ENSMUST00000284371.1 ENSMUSG00000127869 (from geneSymbol) uc333pdp.1 uc333pdp.1 
ENSMUST00000284372.1 ENSMUSG00000127870 ENSMUST00000284372.1 ENSMUSG00000127870 (from geneSymbol) uc333pdq.1 uc333pdq.1 
ENSMUST00000284373.1 ENSMUSG00000127871 ENSMUST00000284373.1 ENSMUSG00000127871 (from geneSymbol) uc333pdr.1 uc333pdr.1 
ENSMUST00000284376.1 ENSMUSG00000127872 ENSMUST00000284376.1 ENSMUSG00000127872 (from geneSymbol) uc333pdu.1 uc333pdu.1 
ENSMUST00000284377.1 ENSMUSG00000127873 ENSMUST00000284377.1 ENSMUSG00000127873 (from geneSymbol) uc333pdv.1 uc333pdv.1 
ENSMUST00000284389.1 ENSMUSG00000127874 ENSMUST00000284389.1 ENSMUSG00000127874 (from geneSymbol) uc333peh.1 uc333peh.1 
ENSMUST00000284394.1 ENSMUSG00000127875 ENSMUST00000284394.1 ENSMUSG00000127875 (from geneSymbol) uc333pem.1 uc333pem.1 
ENSMUST00000284396.1 ENSMUSG00000127876 ENSMUST00000284396.1 ENSMUSG00000127876 (from geneSymbol) uc333peo.1 uc333peo.1 
ENSMUST00000284402.1 ENSMUSG00000127877 ENSMUST00000284402.1 ENSMUSG00000127877 (from geneSymbol) uc333peu.1 uc333peu.1 
ENSMUST00000284410.1 ENSMUSG00000127878 ENSMUST00000284410.1 ENSMUSG00000127878 (from geneSymbol) uc333pfc.1 uc333pfc.1 
ENSMUST00000284411.1 ENSMUSG00000127879 ENSMUST00000284411.1 ENSMUSG00000127879 (from geneSymbol) uc333pfd.1 uc333pfd.1 
ENSMUST00000284412.1 ENSMUSG00000127880 ENSMUST00000284412.1 ENSMUSG00000127880 (from geneSymbol) uc333pfe.1 uc333pfe.1 
ENSMUST00000284415.1 ENSMUSG00000127881 ENSMUST00000284415.1 ENSMUSG00000127881 (from geneSymbol) uc333pfh.1 uc333pfh.1 
ENSMUST00000284419.1 ENSMUSG00000127882 ENSMUST00000284419.1 ENSMUSG00000127882 (from geneSymbol) uc333pfl.1 uc333pfl.1 
ENSMUST00000284420.1 ENSMUSG00000127883 ENSMUST00000284420.1 ENSMUSG00000127883 (from geneSymbol) uc333pfm.1 uc333pfm.1 
ENSMUST00000284422.1 Gm9967 ENSMUST00000284422.1 Gm9967 (from geneSymbol) uc333pfo.1 uc333pfo.1 
ENSMUST00000284435.1 Gm35552 ENSMUST00000284435.1 Gm35552 (from geneSymbol) uc333pga.1 uc333pga.1 
ENSMUST00000284439.1 ENSMUSG00000127884 ENSMUST00000284439.1 ENSMUSG00000127884 (from geneSymbol) LF193151 uc333pge.1 uc333pge.1 
ENSMUST00000284442.1 ENSMUSG00000127885 ENSMUST00000284442.1 ENSMUSG00000127885 (from geneSymbol) uc333pgh.1 uc333pgh.1 
ENSMUST00000284446.1 ENSMUSG00000127887 ENSMUST00000284446.1 ENSMUSG00000127887 (from geneSymbol) uc333pgj.1 uc333pgj.1 
ENSMUST00000284447.1 ENSMUSG00000127888 ENSMUST00000284447.1 ENSMUSG00000127888 (from geneSymbol) uc333pgk.1 uc333pgk.1 
ENSMUST00000284451.1 ENSMUSG00000127889 ENSMUST00000284451.1 ENSMUSG00000127889 (from geneSymbol) uc333pgo.1 uc333pgo.1 
ENSMUST00000284452.1 ENSMUSG00000127890 ENSMUST00000284452.1 ENSMUSG00000127890 (from geneSymbol) uc333pgp.1 uc333pgp.1 
ENSMUST00000284453.1 ENSMUSG00000127891 ENSMUST00000284453.1 ENSMUSG00000127891 (from geneSymbol) uc333pgq.1 uc333pgq.1 
ENSMUST00000284454.1 ENSMUSG00000127892 ENSMUST00000284454.1 ENSMUSG00000127892 (from geneSymbol) uc333pgr.1 uc333pgr.1 
ENSMUST00000284457.1 ENSMUSG00000127893 ENSMUST00000284457.1 ENSMUSG00000127893 (from geneSymbol) uc333pgu.1 uc333pgu.1 
ENSMUST00000284461.1 ENSMUSG00000127894 ENSMUST00000284461.1 ENSMUSG00000127894 (from geneSymbol) uc333pgy.1 uc333pgy.1 
ENSMUST00000284467.1 ENSMUSG00000127895 ENSMUST00000284467.1 ENSMUSG00000127895 (from geneSymbol) uc333phe.1 uc333phe.1 
ENSMUST00000284468.1 ENSMUSG00000127896 ENSMUST00000284468.1 ENSMUSG00000127896 (from geneSymbol) uc333phf.1 uc333phf.1 
ENSMUST00000284469.1 ENSMUSG00000127897 ENSMUST00000284469.1 ENSMUSG00000127897 (from geneSymbol) uc333phg.1 uc333phg.1 
ENSMUST00000284472.1 ENSMUSG00000127898 ENSMUST00000284472.1 ENSMUSG00000127898 (from geneSymbol) uc333phj.1 uc333phj.1 
ENSMUST00000284480.1 9230009I02Rik ENSMUST00000284480.1 9230009I02Rik (from geneSymbol) AK136626 uc333phr.1 uc333phr.1 
ENSMUST00000284482.1 ENSMUSG00000127899 ENSMUST00000284482.1 ENSMUSG00000127899 (from geneSymbol) uc333pht.1 uc333pht.1 
ENSMUST00000284483.1 ENSMUSG00000127901 ENSMUST00000284483.1 ENSMUSG00000127901 (from geneSymbol) uc333phu.1 uc333phu.1 
ENSMUST00000284484.1 ENSMUSG00000127900 ENSMUST00000284484.1 ENSMUSG00000127900 (from geneSymbol) uc333phv.1 uc333phv.1 
ENSMUST00000284485.1 A930002I21Rik ENSMUST00000284485.1 A930002I21Rik (from geneSymbol) AK088812 uc333phw.1 uc333phw.1 
ENSMUST00000284488.1 ENSMUSG00000127902 ENSMUST00000284488.1 ENSMUSG00000127902 (from geneSymbol) uc333phz.1 uc333phz.1 
ENSMUST00000284490.1 Gm15589 ENSMUST00000284490.1 Gm15589 (from geneSymbol) uc333pib.1 uc333pib.1 
ENSMUST00000284491.1 ENSMUSG00000127903 ENSMUST00000284491.1 ENSMUSG00000127903 (from geneSymbol) uc333pic.1 uc333pic.1 
ENSMUST00000284492.1 ENSMUSG00000127904 ENSMUST00000284492.1 ENSMUSG00000127904 (from geneSymbol) uc333pid.1 uc333pid.1 
ENSMUST00000284493.1 ENSMUSG00000127905 ENSMUST00000284493.1 ENSMUSG00000127905 (from geneSymbol) uc333pie.1 uc333pie.1 
ENSMUST00000284494.1 ENSMUSG00000127906 ENSMUST00000284494.1 ENSMUSG00000127906 (from geneSymbol) uc333pif.1 uc333pif.1 
ENSMUST00000284495.1 ENSMUSG00000127907 ENSMUST00000284495.1 ENSMUSG00000127907 (from geneSymbol) uc333pig.1 uc333pig.1 
ENSMUST00000284497.1 ENSMUSG00000127908 ENSMUST00000284497.1 ENSMUSG00000127908 (from geneSymbol) uc333pii.1 uc333pii.1 
ENSMUST00000284499.1 ENSMUSG00000127909 ENSMUST00000284499.1 ENSMUSG00000127909 (from geneSymbol) uc333pik.1 uc333pik.1 
ENSMUST00000284501.1 Gm47028 ENSMUST00000284501.1 Gm47028 (from geneSymbol) uc333pim.1 uc333pim.1 
ENSMUST00000284512.1 ENSMUSG00000127910 ENSMUST00000284512.1 ENSMUSG00000127910 (from geneSymbol) uc333pix.1 uc333pix.1 
ENSMUST00000284515.1 Gm32282 ENSMUST00000284515.1 Gm32282 (from geneSymbol) AK144664 uc333pja.1 uc333pja.1 
ENSMUST00000284517.1 ENSMUSG00000127911 ENSMUST00000284517.1 ENSMUSG00000127911 (from geneSymbol) uc333pjc.1 uc333pjc.1 
ENSMUST00000284536.1 ENSMUSG00000127912 ENSMUST00000284536.1 ENSMUSG00000127912 (from geneSymbol) uc333pjv.1 uc333pjv.1 
ENSMUST00000284540.1 ENSMUSG00000127913 ENSMUST00000284540.1 ENSMUSG00000127913 (from geneSymbol) BC108390 uc333pjz.1 uc333pjz.1 
ENSMUST00000284544.1 ENSMUSG00000127914 ENSMUST00000284544.1 ENSMUSG00000127914 (from geneSymbol) uc333pkd.1 uc333pkd.1 
ENSMUST00000284565.1 ENSMUSG00000127915 ENSMUST00000284565.1 ENSMUSG00000127915 (from geneSymbol) uc333pky.1 uc333pky.1 
ENSMUST00000284643.1 ENSMUSG00000127916 ENSMUST00000284643.1 ENSMUSG00000127916 (from geneSymbol) uc333pny.1 uc333pny.1 
ENSMUST00000284644.1 ENSMUSG00000127917 ENSMUST00000284644.1 ENSMUSG00000127917 (from geneSymbol) BC072564 uc333pnz.1 uc333pnz.1 
ENSMUST00000284650.1 ENSMUSG00000127918 ENSMUST00000284650.1 ENSMUSG00000127918 (from geneSymbol) uc333pof.1 uc333pof.1 
ENSMUST00000284656.1 ENSMUSG00000127919 ENSMUST00000284656.1 ENSMUSG00000127919 (from geneSymbol) uc333pol.1 uc333pol.1 
ENSMUST00000284657.1 ENSMUSG00000127920 ENSMUST00000284657.1 ENSMUSG00000127920 (from geneSymbol) uc333pom.1 uc333pom.1 
ENSMUST00000284658.1 Gm48324 ENSMUST00000284658.1 Gm48324 (from geneSymbol) uc333pon.1 uc333pon.1 
ENSMUST00000284659.1 ENSMUSG00000127921 ENSMUST00000284659.1 ENSMUSG00000127921 (from geneSymbol) uc333poo.1 uc333poo.1 
ENSMUST00000284679.1 ENSMUSG00000127922 ENSMUST00000284679.1 ENSMUSG00000127922 (from geneSymbol) uc333ppi.1 uc333ppi.1 
ENSMUST00000284680.1 ENSMUSG00000127923 ENSMUST00000284680.1 ENSMUSG00000127923 (from geneSymbol) AK206401 uc333ppj.1 uc333ppj.1 
ENSMUST00000284686.1 ENSMUSG00000127926 ENSMUST00000284686.1 ENSMUSG00000127926 (from geneSymbol) uc333ppn.1 uc333ppn.1 
ENSMUST00000284689.1 ENSMUSG00000127927 ENSMUST00000284689.1 ENSMUSG00000127927 (from geneSymbol) uc333ppq.1 uc333ppq.1 
ENSMUST00000284690.1 ENSMUSG00000127928 ENSMUST00000284690.1 ENSMUSG00000127928 (from geneSymbol) uc333ppr.1 uc333ppr.1 
ENSMUST00000284694.1 ENSMUSG00000127929 ENSMUST00000284694.1 ENSMUSG00000127929 (from geneSymbol) uc333ppv.1 uc333ppv.1 
ENSMUST00000284695.1 ENSMUSG00000127930 ENSMUST00000284695.1 ENSMUSG00000127930 (from geneSymbol) uc333ppw.1 uc333ppw.1 
ENSMUST00000284696.1 ENSMUSG00000127931 ENSMUST00000284696.1 ENSMUSG00000127931 (from geneSymbol) uc333ppx.1 uc333ppx.1 
ENSMUST00000284703.1 Ctcflos ENSMUST00000284703.1 Ctcflos (from geneSymbol) AK079954 uc333pqe.1 uc333pqe.1 
ENSMUST00000284748.1 ENSMUSG00000127932 ENSMUST00000284748.1 ENSMUSG00000127932 (from geneSymbol) uc333prw.1 uc333prw.1 
ENSMUST00000284752.1 ENSMUSG00000127933 ENSMUST00000284752.1 ENSMUSG00000127933 (from geneSymbol) uc333psa.1 uc333psa.1 
ENSMUST00000284754.1 ENSMUSG00000127934 ENSMUST00000284754.1 ENSMUSG00000127934 (from geneSymbol) uc333psc.1 uc333psc.1 
ENSMUST00000284755.1 ENSMUSG00000127935 ENSMUST00000284755.1 ENSMUSG00000127935 (from geneSymbol) uc333psd.1 uc333psd.1 
ENSMUST00000284758.1 ENSMUSG00000127936 ENSMUST00000284758.1 ENSMUSG00000127936 (from geneSymbol) uc333psf.1 uc333psf.1 
ENSMUST00000284761.1 ENSMUSG00000127937 ENSMUST00000284761.1 ENSMUSG00000127937 (from geneSymbol) uc333psg.1 uc333psg.1 
ENSMUST00000284776.1 ENSMUSG00000127938 ENSMUST00000284776.1 ENSMUSG00000127938 (from geneSymbol) uc333psv.1 uc333psv.1 
ENSMUST00000284787.1 ENSMUSG00000127939 ENSMUST00000284787.1 ENSMUSG00000127939 (from geneSymbol) uc333ptg.1 uc333ptg.1 
ENSMUST00000284788.1 ENSMUSG00000127940 ENSMUST00000284788.1 ENSMUSG00000127940 (from geneSymbol) uc333pth.1 uc333pth.1 
ENSMUST00000284796.1 ENSMUSG00000121828 ENSMUST00000284796.1 ENSMUSG00000121828 (from geneSymbol) AK036897 uc333ptp.1 uc333ptp.1 
ENSMUST00000284800.1 ENSMUSG00000127941 ENSMUST00000284800.1 ENSMUSG00000127941 (from geneSymbol) uc333ptt.1 uc333ptt.1 
ENSMUST00000284801.1 ENSMUSG00000127942 ENSMUST00000284801.1 ENSMUSG00000127942 (from geneSymbol) uc333ptu.1 uc333ptu.1 
ENSMUST00000284808.1 ENSMUSG00000127943 ENSMUST00000284808.1 ENSMUSG00000127943 (from geneSymbol) uc333pub.1 uc333pub.1 
ENSMUST00000284810.1 ENSMUSG00000127944 ENSMUST00000284810.1 ENSMUSG00000127944 (from geneSymbol) uc333pud.1 uc333pud.1 
ENSMUST00000284812.1 ENSMUSG00000127945 ENSMUST00000284812.1 ENSMUSG00000127945 (from geneSymbol) uc333puf.1 uc333puf.1 
ENSMUST00000284819.1 ENSMUSG00000127946 ENSMUST00000284819.1 ENSMUSG00000127946 (from geneSymbol) uc333pum.1 uc333pum.1 
ENSMUST00000284823.1 ENSMUSG00000127947 ENSMUST00000284823.1 ENSMUSG00000127947 (from geneSymbol) uc333puq.1 uc333puq.1 
ENSMUST00000284824.1 ENSMUSG00000127948 ENSMUST00000284824.1 ENSMUSG00000127948 (from geneSymbol) uc333pur.1 uc333pur.1 
ENSMUST00000284827.1 ENSMUSG00000127950 ENSMUST00000284827.1 ENSMUSG00000127950 (from geneSymbol) uc333put.1 uc333put.1 
ENSMUST00000284830.1 Gm9902 ENSMUST00000284830.1 Gm9902 (from geneSymbol) uc333puw.1 uc333puw.1 
ENSMUST00000284833.1 ENSMUSG00000127951 ENSMUST00000284833.1 ENSMUSG00000127951 (from geneSymbol) uc333puz.1 uc333puz.1 
ENSMUST00000284841.1 ENSMUSG00000127952 ENSMUST00000284841.1 ENSMUSG00000127952 (from geneSymbol) uc333pvh.1 uc333pvh.1 
ENSMUST00000284894.1 ENSMUSG00000127953 ENSMUST00000284894.1 ENSMUSG00000127953 (from geneSymbol) uc333pxi.1 uc333pxi.1 
ENSMUST00000284901.1 ENSMUSG00000127954 ENSMUST00000284901.1 ENSMUSG00000127954 (from geneSymbol) uc333pxp.1 uc333pxp.1 
ENSMUST00000284903.1 ENSMUSG00000127955 ENSMUST00000284903.1 ENSMUSG00000127955 (from geneSymbol) uc333pxr.1 uc333pxr.1 
ENSMUST00000284905.1 ENSMUSG00000127956 ENSMUST00000284905.1 ENSMUSG00000127956 (from geneSymbol) uc333pxt.1 uc333pxt.1 
ENSMUST00000284910.1 ENSMUSG00000127957 ENSMUST00000284910.1 ENSMUSG00000127957 (from geneSymbol) uc333pxx.1 uc333pxx.1 
ENSMUST00000284913.1 Gm56969 ENSMUST00000284913.1 Gm56969 (from geneSymbol) uc333pya.1 uc333pya.1 
ENSMUST00000284916.1 ENSMUSG00000127958 ENSMUST00000284916.1 ENSMUSG00000127958 (from geneSymbol) uc333pyd.1 uc333pyd.1 
ENSMUST00000284917.1 ENSMUSG00000127959 ENSMUST00000284917.1 ENSMUSG00000127959 (from geneSymbol) uc333pye.1 uc333pye.1 
ENSMUST00000284918.1 ENSMUSG00000127960 ENSMUST00000284918.1 ENSMUSG00000127960 (from geneSymbol) uc333pyf.1 uc333pyf.1 
ENSMUST00000284929.1 1700108N06Rik ENSMUST00000284929.1 1700108N06Rik (from geneSymbol) AK007142 uc333pyq.1 uc333pyq.1 
ENSMUST00000284932.1 ENSMUSG00000127961 ENSMUST00000284932.1 ENSMUSG00000127961 (from geneSymbol) uc333pyt.1 uc333pyt.1 
ENSMUST00000284933.1 ENSMUSG00000127962 ENSMUST00000284933.1 ENSMUSG00000127962 (from geneSymbol) uc333pyu.1 uc333pyu.1 
ENSMUST00000284937.1 ENSMUSG00000127963 ENSMUST00000284937.1 ENSMUSG00000127963 (from geneSymbol) uc333pyy.1 uc333pyy.1 
ENSMUST00000284940.1 4930426I24Rik ENSMUST00000284940.1 RIKEN cDNA 4930426I24 gene (from RefSeq NR_166810.1) NR_166810 uc333pzb.1 uc333pzb.1 
ENSMUST00000284958.1 ENSMUSG00000127964 ENSMUST00000284958.1 ENSMUSG00000127964 (from geneSymbol) uc333pzt.1 uc333pzt.1 
ENSMUST00000284959.1 ENSMUSG00000127965 ENSMUST00000284959.1 ENSMUSG00000127965 (from geneSymbol) uc333pzu.1 uc333pzu.1 
ENSMUST00000284960.1 ENSMUSG00000127966 ENSMUST00000284960.1 ENSMUSG00000127966 (from geneSymbol) uc333pzv.1 uc333pzv.1 
ENSMUST00000284962.1 ENSMUSG00000127967 ENSMUST00000284962.1 ENSMUSG00000127967 (from geneSymbol) uc333pzx.1 uc333pzx.1 
ENSMUST00000284969.1 ENSMUSG00000127969 ENSMUST00000284969.1 ENSMUSG00000127969 (from geneSymbol) uc333qad.1 uc333qad.1 
ENSMUST00000284975.1 ENSMUSG00000127970 ENSMUST00000284975.1 ENSMUSG00000127970 (from geneSymbol) uc333qaj.1 uc333qaj.1 
ENSMUST00000284976.1 ENSMUSG00000127971 ENSMUST00000284976.1 ENSMUSG00000127971 (from geneSymbol) uc333qak.1 uc333qak.1 
ENSMUST00000284982.1 4930516B21Rik ENSMUST00000284982.1 4930516B21Rik (from geneSymbol) AK015801 uc333qap.1 uc333qap.1 
ENSMUST00000284984.1 ENSMUSG00000127973 ENSMUST00000284984.1 ENSMUSG00000127973 (from geneSymbol) uc333qar.1 uc333qar.1 
ENSMUST00000284987.1 Gm57344 ENSMUST00000284987.1 Gm57344 (from geneSymbol) uc333qat.1 uc333qat.1 
ENSMUST00000284996.1 ENSMUSG00000127975 ENSMUST00000284996.1 ENSMUSG00000127975 (from geneSymbol) uc333qbc.1 uc333qbc.1 
ENSMUST00000284997.1 ENSMUSG00000127976 ENSMUST00000284997.1 ENSMUSG00000127976 (from geneSymbol) uc333qbd.1 uc333qbd.1 
ENSMUST00000285001.1 ENSMUSG00000127977 ENSMUST00000285001.1 ENSMUSG00000127977 (from geneSymbol) uc333qbh.1 uc333qbh.1 
ENSMUST00000285002.1 Gm47729 ENSMUST00000285002.1 Gm47729 (from geneSymbol) uc333qbi.1 uc333qbi.1 
ENSMUST00000285043.1 ENSMUSG00000127978 ENSMUST00000285043.1 ENSMUSG00000127978 (from geneSymbol) uc333qcx.1 uc333qcx.1 
ENSMUST00000285057.1 1700010I02Rik ENSMUST00000285057.1 1700010I02Rik (from geneSymbol) AK005828 uc333qdl.1 uc333qdl.1 
ENSMUST00000285077.1 ENSMUSG00000127979 ENSMUST00000285077.1 ENSMUSG00000127979 (from geneSymbol) uc333qef.1 uc333qef.1 
ENSMUST00000285083.1 ENSMUSG00000127980 ENSMUST00000285083.1 ENSMUSG00000127980 (from geneSymbol) uc333qel.1 uc333qel.1 
ENSMUST00000285086.1 ENSMUSG00000127981 ENSMUST00000285086.1 ENSMUSG00000127981 (from geneSymbol) uc333qeo.1 uc333qeo.1 
ENSMUST00000285088.1 ENSMUSG00000127982 ENSMUST00000285088.1 ENSMUSG00000127982 (from geneSymbol) uc333qeq.1 uc333qeq.1 
ENSMUST00000285091.1 ENSMUSG00000127983 ENSMUST00000285091.1 ENSMUSG00000127983 (from geneSymbol) uc333qet.1 uc333qet.1 
ENSMUST00000285092.1 ENSMUSG00000127984 ENSMUST00000285092.1 ENSMUSG00000127984 (from geneSymbol) uc333qeu.1 uc333qeu.1 
ENSMUST00000285095.1 ENSMUSG00000127985 ENSMUST00000285095.1 ENSMUSG00000127985 (from geneSymbol) uc333qex.1 uc333qex.1 
ENSMUST00000285096.1 ENSMUSG00000127986 ENSMUST00000285096.1 ENSMUSG00000127986 (from geneSymbol) uc333qey.1 uc333qey.1 
ENSMUST00000285097.1 ENSMUSG00000127987 ENSMUST00000285097.1 ENSMUSG00000127987 (from geneSymbol) uc333qez.1 uc333qez.1 
ENSMUST00000285099.1 ENSMUSG00000127988 ENSMUST00000285099.1 ENSMUSG00000127988 (from geneSymbol) uc333qfb.1 uc333qfb.1 
ENSMUST00000285101.1 ENSMUSG00000127989 ENSMUST00000285101.1 ENSMUSG00000127989 (from geneSymbol) uc333qfd.1 uc333qfd.1 
ENSMUST00000285102.1 ENSMUSG00000127990 ENSMUST00000285102.1 ENSMUSG00000127990 (from geneSymbol) uc333qfe.1 uc333qfe.1 
ENSMUST00000285103.1 ENSMUSG00000127991 ENSMUST00000285103.1 ENSMUSG00000127991 (from geneSymbol) uc333qff.1 uc333qff.1 
ENSMUST00000285115.1 ENSMUSG00000127992 ENSMUST00000285115.1 ENSMUSG00000127992 (from geneSymbol) uc333qfr.1 uc333qfr.1 
ENSMUST00000285121.1 ENSMUSG00000127993 ENSMUST00000285121.1 ENSMUSG00000127993 (from geneSymbol) uc333qfx.1 uc333qfx.1 
ENSMUST00000285122.1 ENSMUSG00000127994 ENSMUST00000285122.1 ENSMUSG00000127994 (from geneSymbol) BC072564 uc333qfy.1 uc333qfy.1 
ENSMUST00000285125.1 1700030C10Rik ENSMUST00000285125.1 1700030C10Rik (from geneSymbol) BC100365 uc333qgb.1 uc333qgb.1 
ENSMUST00000285142.1 ENSMUSG00000127995 ENSMUST00000285142.1 ENSMUSG00000127995 (from geneSymbol) uc333qgs.1 uc333qgs.1 
ENSMUST00000285147.1 Gm31904 ENSMUST00000285147.1 Gm31904 (from geneSymbol) uc333qgx.1 uc333qgx.1 
ENSMUST00000285159.1 ENSMUSG00000127996 ENSMUST00000285159.1 ENSMUSG00000127996 (from geneSymbol) uc333qhj.1 uc333qhj.1 
ENSMUST00000285164.1 ENSMUSG00000127997 ENSMUST00000285164.1 ENSMUSG00000127997 (from geneSymbol) uc333qho.1 uc333qho.1 
ENSMUST00000285166.1 ENSMUSG00000127998 ENSMUST00000285166.1 ENSMUSG00000127998 (from geneSymbol) uc333qhq.1 uc333qhq.1 
ENSMUST00000285170.1 Gm47947 ENSMUST00000285170.1 Gm47947 (from geneSymbol) uc333qhu.1 uc333qhu.1 
ENSMUST00000285190.1 Gm16701 ENSMUST00000285190.1 Gm16701 (from geneSymbol) uc333qio.1 uc333qio.1 
ENSMUST00000285205.1 ENSMUSG00000127999 ENSMUST00000285205.1 ENSMUSG00000127999 (from geneSymbol) uc333qjd.1 uc333qjd.1 
ENSMUST00000285206.1 ENSMUSG00000128000 ENSMUST00000285206.1 ENSMUSG00000128000 (from geneSymbol) uc333qje.1 uc333qje.1 
ENSMUST00000285207.1 ENSMUSG00000128001 ENSMUST00000285207.1 ENSMUSG00000128001 (from geneSymbol) AK015523 uc333qjf.1 uc333qjf.1 
ENSMUST00000285208.1 ENSMUSG00000128002 ENSMUST00000285208.1 ENSMUSG00000128002 (from geneSymbol) uc333qjg.1 uc333qjg.1 
ENSMUST00000285222.1 ENSMUSG00000128003 ENSMUST00000285222.1 ENSMUSG00000128003 (from geneSymbol) uc333qju.1 uc333qju.1 
ENSMUST00000285224.1 ENSMUSG00000128004 ENSMUST00000285224.1 ENSMUSG00000128004 (from geneSymbol) uc333qjv.1 uc333qjv.1 
ENSMUST00000285225.1 ENSMUSG00000128005 ENSMUST00000285225.1 ENSMUSG00000128005 (from geneSymbol) uc333qjw.1 uc333qjw.1 
ENSMUST00000285227.1 ENSMUSG00000128006 ENSMUST00000285227.1 ENSMUSG00000128006 (from geneSymbol) uc333qjy.1 uc333qjy.1 
ENSMUST00000285228.1 ENSMUSG00000128007 ENSMUST00000285228.1 ENSMUSG00000128007 (from geneSymbol) uc333qjz.1 uc333qjz.1 
ENSMUST00000285233.1 ENSMUSG00000128008 ENSMUST00000285233.1 ENSMUSG00000128008 (from geneSymbol) uc333qke.1 uc333qke.1 
ENSMUST00000285234.1 ENSMUSG00000128009 ENSMUST00000285234.1 ENSMUSG00000128009 (from geneSymbol) uc333qkf.1 uc333qkf.1 
ENSMUST00000285237.1 ENSMUSG00000128010 ENSMUST00000285237.1 ENSMUSG00000128010 (from geneSymbol) uc333qki.1 uc333qki.1 
ENSMUST00000285238.1 ENSMUSG00000128011 ENSMUST00000285238.1 ENSMUSG00000128011 (from geneSymbol) uc333qkj.1 uc333qkj.1 
ENSMUST00000285249.1 ENSMUSG00000128012 ENSMUST00000285249.1 ENSMUSG00000128012 (from geneSymbol) uc333qkt.1 uc333qkt.1 
ENSMUST00000285253.1 ENSMUSG00000128013 ENSMUST00000285253.1 ENSMUSG00000128013 (from geneSymbol) uc333qkx.1 uc333qkx.1 
ENSMUST00000285257.1 Gm49860 ENSMUST00000285257.1 Gm49860 (from geneSymbol) uc333qlb.1 uc333qlb.1 
ENSMUST00000285269.1 ENSMUSG00000128014 ENSMUST00000285269.1 ENSMUSG00000128014 (from geneSymbol) uc333qln.1 uc333qln.1 
ENSMUST00000285271.1 ENSMUSG00000128015 ENSMUST00000285271.1 ENSMUSG00000128015 (from geneSymbol) uc333qlp.1 uc333qlp.1 
ENSMUST00000285272.1 Gm57185 ENSMUST00000285272.1 Gm57185 (from geneSymbol) uc333qlq.1 uc333qlq.1 
ENSMUST00000285285.1 Gm26747 ENSMUST00000285285.1 Gm26747 (from geneSymbol) uc333qmd.1 uc333qmd.1 
ENSMUST00000285289.1 ENSMUSG00000128016 ENSMUST00000285289.1 ENSMUSG00000128016 (from geneSymbol) uc333qmh.1 uc333qmh.1 
ENSMUST00000285290.1 ENSMUSG00000128017 ENSMUST00000285290.1 ENSMUSG00000128017 (from geneSymbol) uc333qmi.1 uc333qmi.1 
ENSMUST00000285291.1 ENSMUSG00000128018 ENSMUST00000285291.1 ENSMUSG00000128018 (from geneSymbol) uc333qmj.1 uc333qmj.1 
ENSMUST00000285293.1 ENSMUSG00000128019 ENSMUST00000285293.1 ENSMUSG00000128019 (from geneSymbol) uc333qml.1 uc333qml.1 
ENSMUST00000285297.1 ENSMUSG00000128020 ENSMUST00000285297.1 ENSMUSG00000128020 (from geneSymbol) uc333qmp.1 uc333qmp.1 
ENSMUST00000285301.1 ENSMUSG00000128021 ENSMUST00000285301.1 ENSMUSG00000128021 (from geneSymbol) uc333qmt.1 uc333qmt.1 
ENSMUST00000285303.1 ENSMUSG00000128022 ENSMUST00000285303.1 ENSMUSG00000128022 (from geneSymbol) AK008001 uc333qmv.1 uc333qmv.1 
ENSMUST00000285309.1 Gm7367 ENSMUST00000285309.1 predicted pseudogene 7367 (from RefSeq NR_003376.2) NR_003376 uc333qnb.1 uc333qnb.1 
ENSMUST00000285310.1 ENSMUSG00000128024 ENSMUST00000285310.1 ENSMUSG00000128024 (from geneSymbol) uc333qnc.1 uc333qnc.1 
ENSMUST00000285311.1 ENSMUSG00000128025 ENSMUST00000285311.1 ENSMUSG00000128025 (from geneSymbol) uc333qnd.1 uc333qnd.1 
ENSMUST00000285314.1 ENSMUSG00000128026 ENSMUST00000285314.1 ENSMUSG00000128026 (from geneSymbol) uc333qng.1 uc333qng.1 
ENSMUST00000285316.1 ENSMUSG00000128027 ENSMUST00000285316.1 ENSMUSG00000128027 (from geneSymbol) uc333qni.1 uc333qni.1 
ENSMUST00000285320.1 ENSMUSG00000128028 ENSMUST00000285320.1 ENSMUSG00000128028 (from geneSymbol) uc333qnm.1 uc333qnm.1 
ENSMUST00000285322.1 ENSMUSG00000128029 ENSMUST00000285322.1 ENSMUSG00000128029 (from geneSymbol) uc333qno.1 uc333qno.1 
ENSMUST00000285324.1 ENSMUSG00000128030 ENSMUST00000285324.1 ENSMUSG00000128030 (from geneSymbol) uc333qnq.1 uc333qnq.1 
ENSMUST00000285328.1 Gm5577 ENSMUST00000285328.1 Gm5577 (from geneSymbol) AK020089 uc333qnu.1 uc333qnu.1 
ENSMUST00000285348.1 ENSMUSG00000128031 ENSMUST00000285348.1 ENSMUSG00000128031 (from geneSymbol) uc333qoo.1 uc333qoo.1 
ENSMUST00000285350.1 ENSMUSG00000128032 ENSMUST00000285350.1 ENSMUSG00000128032 (from geneSymbol) uc333qoq.1 uc333qoq.1 
ENSMUST00000285377.1 Gm41349 ENSMUST00000285377.1 Gm41349 (from geneSymbol) uc333qpr.1 uc333qpr.1 
ENSMUST00000285382.1 ENSMUSG00000128033 ENSMUST00000285382.1 ENSMUSG00000128033 (from geneSymbol) uc333qpw.1 uc333qpw.1 
ENSMUST00000285383.1 ENSMUSG00000121760 ENSMUST00000285383.1 ENSMUSG00000121760 (from geneSymbol) uc333qpx.1 uc333qpx.1 
ENSMUST00000285384.1 Gm36640 ENSMUST00000285384.1 Gm36640 (from geneSymbol) BC072574 uc333qpy.1 uc333qpy.1 
ENSMUST00000285390.1 ENSMUSG00000128034 ENSMUST00000285390.1 ENSMUSG00000128034 (from geneSymbol) uc333qqe.1 uc333qqe.1 
ENSMUST00000285397.1 ENSMUSG00000128035 ENSMUST00000285397.1 ENSMUSG00000128035 (from geneSymbol) uc333qql.1 uc333qql.1 
ENSMUST00000285401.1 ENSMUSG00000128036 ENSMUST00000285401.1 ENSMUSG00000128036 (from geneSymbol) uc333qqp.1 uc333qqp.1 
ENSMUST00000285404.1 Gm53610 ENSMUST00000285404.1 Gm53610 (from geneSymbol) uc333qqs.1 uc333qqs.1 
ENSMUST00000285430.1 ENSMUSG00000128037 ENSMUST00000285430.1 ENSMUSG00000128037 (from geneSymbol) uc333qrs.1 uc333qrs.1 
ENSMUST00000285431.1 ENSMUSG00000128038 ENSMUST00000285431.1 ENSMUSG00000128038 (from geneSymbol) uc333qrt.1 uc333qrt.1 
ENSMUST00000285433.1 Gm40331 ENSMUST00000285433.1 Gm40331 (from geneSymbol) uc333qrv.1 uc333qrv.1 
ENSMUST00000285459.1 ENSMUSG00000128039 ENSMUST00000285459.1 ENSMUSG00000128039 (from geneSymbol) uc333qsv.1 uc333qsv.1 
ENSMUST00000285461.1 ENSMUSG00000128040 ENSMUST00000285461.1 ENSMUSG00000128040 (from geneSymbol) uc333qsw.1 uc333qsw.1 
ENSMUST00000285467.1 ENSMUSG00000128041 ENSMUST00000285467.1 ENSMUSG00000128041 (from geneSymbol) uc333qtc.1 uc333qtc.1 
ENSMUST00000285470.1 Gm30108 ENSMUST00000285470.1 Gm30108 (from geneSymbol) AK039820 uc333qtf.1 uc333qtf.1 
ENSMUST00000285474.1 ENSMUSG00000128042 ENSMUST00000285474.1 ENSMUSG00000128042 (from geneSymbol) uc333qtj.1 uc333qtj.1 
ENSMUST00000285476.1 ENSMUSG00000128043 ENSMUST00000285476.1 ENSMUSG00000128043 (from geneSymbol) uc333qtl.1 uc333qtl.1 
ENSMUST00000285481.1 ENSMUSG00000128044 ENSMUST00000285481.1 ENSMUSG00000128044 (from geneSymbol) uc333qtq.1 uc333qtq.1 
ENSMUST00000285483.1 ENSMUSG00000128045 ENSMUST00000285483.1 ENSMUSG00000128045 (from geneSymbol) uc333qts.1 uc333qts.1 
ENSMUST00000285491.1 ENSMUSG00000128046 ENSMUST00000285491.1 ENSMUSG00000128046 (from geneSymbol) uc333qua.1 uc333qua.1 
ENSMUST00000285495.1 Mir503hg ENSMUST00000285495.1 Uncharacterized LOC119919412 (from RefSeq NR_171386.1) NR_171386 uc333que.1 uc333que.1 
ENSMUST00000285498.1 ENSMUSG00000128047 ENSMUST00000285498.1 ENSMUSG00000128047 (from geneSymbol) uc333quh.1 uc333quh.1 
ENSMUST00000285499.1 ENSMUSG00000128048 ENSMUST00000285499.1 ENSMUSG00000128048 (from geneSymbol) uc333qui.1 uc333qui.1 
ENSMUST00000285501.1 ENSMUSG00000128049 ENSMUST00000285501.1 ENSMUSG00000128049 (from geneSymbol) uc333quk.1 uc333quk.1 
ENSMUST00000285502.1 ENSMUSG00000128050 ENSMUST00000285502.1 ENSMUSG00000128050 (from geneSymbol) uc333qul.1 uc333qul.1 
ENSMUST00000285505.1 ENSMUSG00000128051 ENSMUST00000285505.1 ENSMUSG00000128051 (from geneSymbol) uc333quo.1 uc333quo.1 
ENSMUST00000285510.1 ENSMUSG00000128052 ENSMUST00000285510.1 ENSMUSG00000128052 (from geneSymbol) uc333quq.1 uc333quq.1 
ENSMUST00000285511.1 ENSMUSG00000128053 ENSMUST00000285511.1 ENSMUSG00000128053 (from geneSymbol) uc333qur.1 uc333qur.1 
ENSMUST00000285513.1 ENSMUSG00000128054 ENSMUST00000285513.1 ENSMUSG00000128054 (from geneSymbol) uc333qut.1 uc333qut.1 
ENSMUST00000285518.1 Gm33501 ENSMUST00000285518.1 Gm33501 (from geneSymbol) uc333quy.1 uc333quy.1 
ENSMUST00000285521.1 ENSMUSG00000128055 ENSMUST00000285521.1 ENSMUSG00000128055 (from geneSymbol) uc333qvb.1 uc333qvb.1 
ENSMUST00000285522.1 ENSMUSG00000128056 ENSMUST00000285522.1 ENSMUSG00000128056 (from geneSymbol) uc333qvc.1 uc333qvc.1 
ENSMUST00000285524.1 ENSMUSG00000128058 ENSMUST00000285524.1 ENSMUSG00000128058 (from geneSymbol) uc333qvd.1 uc333qvd.1 
ENSMUST00000285525.1 ENSMUSG00000128059 ENSMUST00000285525.1 ENSMUSG00000128059 (from geneSymbol) uc333qve.1 uc333qve.1 
ENSMUST00000285526.1 ENSMUSG00000128060 ENSMUST00000285526.1 ENSMUSG00000128060 (from geneSymbol) uc333qvf.1 uc333qvf.1 
ENSMUST00000285532.1 ENSMUSG00000128061 ENSMUST00000285532.1 ENSMUSG00000128061 (from geneSymbol) uc333qvl.1 uc333qvl.1 
ENSMUST00000285534.1 ENSMUSG00000128062 ENSMUST00000285534.1 ENSMUSG00000128062 (from geneSymbol) uc333qvn.1 uc333qvn.1 
ENSMUST00000285539.1 ENSMUSG00000128063 ENSMUST00000285539.1 ENSMUSG00000128063 (from geneSymbol) uc333qvs.1 uc333qvs.1 
ENSMUST00000285540.1 ENSMUSG00000128064 ENSMUST00000285540.1 ENSMUSG00000128064 (from geneSymbol) uc333qvt.1 uc333qvt.1 
ENSMUST00000285541.1 ENSMUSG00000128065 ENSMUST00000285541.1 ENSMUSG00000128065 (from geneSymbol) uc333qvu.1 uc333qvu.1 
ENSMUST00000285543.1 ENSMUSG00000128066 ENSMUST00000285543.1 ENSMUSG00000128066 (from geneSymbol) uc333qvw.1 uc333qvw.1 
ENSMUST00000285544.1 ENSMUSG00000128067 ENSMUST00000285544.1 ENSMUSG00000128067 (from geneSymbol) uc333qvx.1 uc333qvx.1 
ENSMUST00000285548.1 Map2k3os ENSMUST00000285548.1 Map2k3os (from geneSymbol) BC031537 uc333qwb.1 uc333qwb.1 
ENSMUST00000285552.1 ENSMUSG00000128068 ENSMUST00000285552.1 ENSMUSG00000128068 (from geneSymbol) uc333qwf.1 uc333qwf.1 
ENSMUST00000285553.1 ENSMUSG00000128069 ENSMUST00000285553.1 ENSMUSG00000128069 (from geneSymbol) uc333qwg.1 uc333qwg.1 
ENSMUST00000285556.1 ENSMUSG00000128070 ENSMUST00000285556.1 ENSMUSG00000128070 (from geneSymbol) uc333qwj.1 uc333qwj.1 
ENSMUST00000285557.1 ENSMUSG00000128071 ENSMUST00000285557.1 ENSMUSG00000128071 (from geneSymbol) uc333qwk.1 uc333qwk.1 
ENSMUST00000285558.1 ENSMUSG00000128072 ENSMUST00000285558.1 ENSMUSG00000128072 (from geneSymbol) uc333qwl.1 uc333qwl.1 
ENSMUST00000285560.1 ENSMUSG00000128073 ENSMUST00000285560.1 ENSMUSG00000128073 (from geneSymbol) uc333qwn.1 uc333qwn.1 
ENSMUST00000285562.1 ENSMUSG00000128074 ENSMUST00000285562.1 ENSMUSG00000128074 (from geneSymbol) uc333qwo.1 uc333qwo.1 
ENSMUST00000285579.1 ENSMUSG00000128075 ENSMUST00000285579.1 ENSMUSG00000128075 (from geneSymbol) AK040317 uc333qxf.1 uc333qxf.1 
ENSMUST00000285580.1 1110058D11Rik ENSMUST00000285580.1 1110058D11Rik (from geneSymbol) AK004294 uc333qxg.1 uc333qxg.1 
ENSMUST00000285590.1 ENSMUSG00000128077 ENSMUST00000285590.1 ENSMUSG00000128077 (from geneSymbol) uc333qxq.1 uc333qxq.1 
ENSMUST00000285591.1 ENSMUSG00000128078 ENSMUST00000285591.1 ENSMUSG00000128078 (from geneSymbol) uc333qxr.1 uc333qxr.1 
ENSMUST00000285597.1 ENSMUSG00000128080 ENSMUST00000285597.1 ENSMUSG00000128080 (from geneSymbol) uc333qxs.1 uc333qxs.1 
ENSMUST00000285598.1 ENSMUSG00000128081 ENSMUST00000285598.1 ENSMUSG00000128081 (from geneSymbol) uc333qxt.1 uc333qxt.1 
ENSMUST00000285599.1 ENSMUSG00000128082 ENSMUST00000285599.1 ENSMUSG00000128082 (from geneSymbol) uc333qxu.1 uc333qxu.1 
ENSMUST00000285602.1 Platr16 ENSMUST00000285602.1 Platr16 (from geneSymbol) uc333qxx.1 uc333qxx.1 
ENSMUST00000285615.1 ENSMUSG00000128083 ENSMUST00000285615.1 ENSMUSG00000128083 (from geneSymbol) uc333qyk.1 uc333qyk.1 
ENSMUST00000285617.1 Gm32281 ENSMUST00000285617.1 Gm32281 (from geneSymbol) uc333qyl.1 uc333qyl.1 
ENSMUST00000285634.1 ENSMUSG00000128084 ENSMUST00000285634.1 ENSMUSG00000128084 (from geneSymbol) uc333qzb.1 uc333qzb.1 
ENSMUST00000285635.1 ENSMUSG00000128085 ENSMUST00000285635.1 ENSMUSG00000128085 (from geneSymbol) uc333qzc.1 uc333qzc.1 
ENSMUST00000285636.1 ENSMUSG00000128086 ENSMUST00000285636.1 ENSMUSG00000128086 (from geneSymbol) uc333qzd.1 uc333qzd.1 
ENSMUST00000285639.1 ENSMUSG00000128087 ENSMUST00000285639.1 ENSMUSG00000128087 (from geneSymbol) uc333qzg.1 uc333qzg.1 
ENSMUST00000285640.1 ENSMUSG00000128088 ENSMUST00000285640.1 ENSMUSG00000128088 (from geneSymbol) uc333qzh.1 uc333qzh.1 
ENSMUST00000285643.1 Gm28441 ENSMUST00000285643.1 Gm28441 (from geneSymbol) AK132987 uc333qzk.1 uc333qzk.1 
ENSMUST00000285650.1 ENSMUSG00000128089 ENSMUST00000285650.1 ENSMUSG00000128089 (from geneSymbol) uc333qzr.1 uc333qzr.1 
ENSMUST00000285651.1 ENSMUSG00000128090 ENSMUST00000285651.1 ENSMUSG00000128090 (from geneSymbol) uc333qzs.1 uc333qzs.1 
ENSMUST00000285652.1 ENSMUSG00000128091 ENSMUST00000285652.1 ENSMUSG00000128091 (from geneSymbol) uc333qzt.1 uc333qzt.1 
ENSMUST00000285653.1 ENSMUSG00000128092 ENSMUST00000285653.1 ENSMUSG00000128092 (from geneSymbol) uc333qzu.1 uc333qzu.1 
ENSMUST00000285656.1 ENSMUSG00000128093 ENSMUST00000285656.1 ENSMUSG00000128093 (from geneSymbol) uc333qzx.1 uc333qzx.1 
ENSMUST00000285664.1 1700080N15Rik ENSMUST00000285664.1 1700080N15Rik (from geneSymbol) AK006958 uc333raf.1 uc333raf.1 
ENSMUST00000285672.1 ENSMUSG00000128094 ENSMUST00000285672.1 ENSMUSG00000128094 (from geneSymbol) uc333ran.1 uc333ran.1 
ENSMUST00000285674.1 ENSMUSG00000128095 ENSMUST00000285674.1 ENSMUSG00000128095 (from geneSymbol) uc333rap.1 uc333rap.1 
ENSMUST00000285675.1 ENSMUSG00000128096 ENSMUST00000285675.1 ENSMUSG00000128096 (from geneSymbol) uc333raq.1 uc333raq.1 
ENSMUST00000285676.1 ENSMUSG00000128097 ENSMUST00000285676.1 ENSMUSG00000128097 (from geneSymbol) uc333rar.1 uc333rar.1 
ENSMUST00000285682.1 ENSMUSG00000128098 ENSMUST00000285682.1 ENSMUSG00000128098 (from geneSymbol) uc333rax.1 uc333rax.1 
ENSMUST00000285693.1 Gm56758 ENSMUST00000285693.1 Gm56758 (from geneSymbol) uc333rbi.1 uc333rbi.1 
ENSMUST00000285697.1 ENSMUSG00000128099 ENSMUST00000285697.1 ENSMUSG00000128099 (from geneSymbol) uc333rbm.1 uc333rbm.1 
ENSMUST00000285698.1 ENSMUSG00000128100 ENSMUST00000285698.1 ENSMUSG00000128100 (from geneSymbol) uc333rbn.1 uc333rbn.1 
ENSMUST00000285700.1 ENSMUSG00000128101 ENSMUST00000285700.1 ENSMUSG00000128101 (from geneSymbol) uc333rbp.1 uc333rbp.1 
ENSMUST00000285719.1 ENSMUSG00000128102 ENSMUST00000285719.1 ENSMUSG00000128102 (from geneSymbol) uc333rci.1 uc333rci.1 
ENSMUST00000285721.1 ENSMUSG00000128103 ENSMUST00000285721.1 ENSMUSG00000128103 (from geneSymbol) uc333rck.1 uc333rck.1 
ENSMUST00000285727.1 9530052E02Rik ENSMUST00000285727.1 9530052E02Rik (from geneSymbol) AK162519 uc333rcq.1 uc333rcq.1 
ENSMUST00000285733.1 ENSMUSG00000128104 ENSMUST00000285733.1 ENSMUSG00000128104 (from geneSymbol) uc333rcw.1 uc333rcw.1 
ENSMUST00000285748.1 ENSMUSG00000128105 ENSMUST00000285748.1 ENSMUSG00000128105 (from geneSymbol) uc333rdl.1 uc333rdl.1 
ENSMUST00000285753.1 ENSMUSG00000128106 ENSMUST00000285753.1 ENSMUSG00000128106 (from geneSymbol) uc333rdq.1 uc333rdq.1 
ENSMUST00000285758.1 ENSMUSG00000128107 ENSMUST00000285758.1 ENSMUSG00000128107 (from geneSymbol) uc333rdv.1 uc333rdv.1 
ENSMUST00000285769.1 ENSMUSG00000128108 ENSMUST00000285769.1 ENSMUSG00000128108 (from geneSymbol) uc333reg.1 uc333reg.1 
ENSMUST00000285770.1 ENSMUSG00000128109 ENSMUST00000285770.1 ENSMUSG00000128109 (from geneSymbol) uc333reh.1 uc333reh.1 
ENSMUST00000285771.1 ENSMUSG00000128110 ENSMUST00000285771.1 ENSMUSG00000128110 (from geneSymbol) uc333rei.1 uc333rei.1 
ENSMUST00000285774.1 ENSMUSG00000128111 ENSMUST00000285774.1 ENSMUSG00000128111 (from geneSymbol) uc333rel.1 uc333rel.1 
ENSMUST00000285782.1 ENSMUSG00000128112 ENSMUST00000285782.1 ENSMUSG00000128112 (from geneSymbol) uc333ret.1 uc333ret.1 
ENSMUST00000285790.1 ENSMUSG00000128113 ENSMUST00000285790.1 ENSMUSG00000128113 (from geneSymbol) uc333rfb.1 uc333rfb.1 
ENSMUST00000285793.1 ENSMUSG00000128114 ENSMUST00000285793.1 ENSMUSG00000128114 (from geneSymbol) uc333rfe.1 uc333rfe.1 
ENSMUST00000285796.1 ENSMUSG00000128115 ENSMUST00000285796.1 ENSMUSG00000128115 (from geneSymbol) uc333rfh.1 uc333rfh.1 
ENSMUST00000285799.1 ENSMUSG00000128116 ENSMUST00000285799.1 ENSMUSG00000128116 (from geneSymbol) uc333rfk.1 uc333rfk.1 
ENSMUST00000285801.1 ENSMUSG00000128117 ENSMUST00000285801.1 ENSMUSG00000128117 (from geneSymbol) uc333rfm.1 uc333rfm.1 
ENSMUST00000285803.1 ENSMUSG00000128118 ENSMUST00000285803.1 ENSMUSG00000128118 (from geneSymbol) uc333rfo.1 uc333rfo.1 
ENSMUST00000285807.1 ENSMUSG00000128119 ENSMUST00000285807.1 ENSMUSG00000128119 (from geneSymbol) uc333rfs.1 uc333rfs.1 
ENSMUST00000285810.1 ENSMUSG00000128120 ENSMUST00000285810.1 ENSMUSG00000128120 (from geneSymbol) uc333rfv.1 uc333rfv.1 
ENSMUST00000285840.1 ENSMUSG00000128121 ENSMUST00000285840.1 ENSMUSG00000128121 (from geneSymbol) uc333rgp.1 uc333rgp.1 
ENSMUST00000285853.1 ENSMUSG00000128122 ENSMUST00000285853.1 ENSMUSG00000128122 (from geneSymbol) uc333rhc.1 uc333rhc.1 
ENSMUST00000285854.1 ENSMUSG00000128123 ENSMUST00000285854.1 ENSMUSG00000128123 (from geneSymbol) uc333rhd.1 uc333rhd.1 
ENSMUST00000285855.1 ENSMUSG00000128124 ENSMUST00000285855.1 ENSMUSG00000128124 (from geneSymbol) uc333rhe.1 uc333rhe.1 
ENSMUST00000285856.1 ENSMUSG00000128125 ENSMUST00000285856.1 ENSMUSG00000128125 (from geneSymbol) uc333rhf.1 uc333rhf.1 
ENSMUST00000285894.1 ENSMUSG00000128126 ENSMUST00000285894.1 ENSMUSG00000128126 (from geneSymbol) uc333rir.1 uc333rir.1 
ENSMUST00000285895.1 ENSMUSG00000128127 ENSMUST00000285895.1 ENSMUSG00000128127 (from geneSymbol) uc333ris.1 uc333ris.1 
ENSMUST00000285896.1 ENSMUSG00000128128 ENSMUST00000285896.1 ENSMUSG00000128128 (from geneSymbol) uc333rit.1 uc333rit.1 
ENSMUST00000285897.1 ENSMUSG00000128129 ENSMUST00000285897.1 ENSMUSG00000128129 (from geneSymbol) uc333riu.1 uc333riu.1 
ENSMUST00000285899.1 ENSMUSG00000128130 ENSMUST00000285899.1 ENSMUSG00000128130 (from geneSymbol) uc333riw.1 uc333riw.1 
ENSMUST00000285900.1 ENSMUSG00000128131 ENSMUST00000285900.1 ENSMUSG00000128131 (from geneSymbol) uc333rix.1 uc333rix.1 
ENSMUST00000285902.1 ENSMUSG00000128132 ENSMUST00000285902.1 ENSMUSG00000128132 (from geneSymbol) uc333riz.1 uc333riz.1 
ENSMUST00000285903.1 ENSMUSG00000128133 ENSMUST00000285903.1 ENSMUSG00000128133 (from geneSymbol) uc333rja.1 uc333rja.1 
ENSMUST00000285904.1 Gm48749 ENSMUST00000285904.1 Gm48749 (from geneSymbol) uc333rjb.1 uc333rjb.1 
ENSMUST00000285919.1 Clnkos ENSMUST00000285919.1 Clnkos (from geneSymbol) AK006226 uc333rjq.1 uc333rjq.1 
ENSMUST00000285920.1 ENSMUSG00000128134 ENSMUST00000285920.1 ENSMUSG00000128134 (from geneSymbol) uc333rjr.1 uc333rjr.1 
ENSMUST00000285921.1 ENSMUSG00000128135 ENSMUST00000285921.1 ENSMUSG00000128135 (from geneSymbol) uc333rjs.1 uc333rjs.1 
ENSMUST00000285926.1 Gm20655 ENSMUST00000285926.1 Gm20655 (from geneSymbol) AK089945 uc333rjx.1 uc333rjx.1 
ENSMUST00000285947.1 ENSMUSG00000128136 ENSMUST00000285947.1 ENSMUSG00000128136 (from geneSymbol) uc333rks.1 uc333rks.1 
ENSMUST00000285956.1 ENSMUSG00000128137 ENSMUST00000285956.1 ENSMUSG00000128137 (from geneSymbol) uc333rlb.1 uc333rlb.1 
ENSMUST00000285958.1 ENSMUSG00000128138 ENSMUST00000285958.1 ENSMUSG00000128138 (from geneSymbol) uc333rld.1 uc333rld.1 
ENSMUST00000285959.1 ENSMUSG00000128139 ENSMUST00000285959.1 ENSMUSG00000128139 (from geneSymbol) FV528054 uc333rle.1 uc333rle.1 
ENSMUST00000285961.1 ENSMUSG00000128140 ENSMUST00000285961.1 ENSMUSG00000128140 (from geneSymbol) uc333rlg.1 uc333rlg.1 
ENSMUST00000285964.1 ENSMUSG00000128141 ENSMUST00000285964.1 ENSMUSG00000128141 (from geneSymbol) uc333rlj.1 uc333rlj.1 
ENSMUST00000285973.1 0610006L08Rik ENSMUST00000285973.1 0610006L08Rik (from geneSymbol) AK002255 uc333rls.1 uc333rls.1 
ENSMUST00000285980.1 ENSMUSG00000128142 ENSMUST00000285980.1 ENSMUSG00000128142 (from geneSymbol) uc333rlz.1 uc333rlz.1 
ENSMUST00000285983.1 ENSMUSG00000128143 ENSMUST00000285983.1 ENSMUSG00000128143 (from geneSymbol) uc333rmc.1 uc333rmc.1 
ENSMUST00000285985.1 ENSMUSG00000128144 ENSMUST00000285985.1 ENSMUSG00000128144 (from geneSymbol) uc333rme.1 uc333rme.1 
ENSMUST00000285986.1 ENSMUSG00000128145 ENSMUST00000285986.1 ENSMUSG00000128145 (from geneSymbol) uc333rmf.1 uc333rmf.1 
ENSMUST00000285989.1 ENSMUSG00000128146 ENSMUST00000285989.1 ENSMUSG00000128146 (from geneSymbol) uc333rmi.1 uc333rmi.1 
ENSMUST00000285991.1 ENSMUSG00000128147 ENSMUST00000285991.1 ENSMUSG00000128147 (from geneSymbol) uc333rmk.1 uc333rmk.1 
ENSMUST00000285992.1 ENSMUSG00000128148 ENSMUST00000285992.1 ENSMUSG00000128148 (from geneSymbol) uc333rml.1 uc333rml.1 
ENSMUST00000285995.1 ENSMUSG00000128149 ENSMUST00000285995.1 ENSMUSG00000128149 (from geneSymbol) uc333rmo.1 uc333rmo.1 
ENSMUST00000285997.1 ENSMUSG00000128150 ENSMUST00000285997.1 ENSMUSG00000128150 (from geneSymbol) uc333rmq.1 uc333rmq.1 
ENSMUST00000285999.1 ENSMUSG00000128151 ENSMUST00000285999.1 ENSMUSG00000128151 (from geneSymbol) uc333rms.1 uc333rms.1 
ENSMUST00000286008.1 ENSMUSG00000128152 ENSMUST00000286008.1 ENSMUSG00000128152 (from geneSymbol) uc333rnb.1 uc333rnb.1 
ENSMUST00000286010.1 ENSMUSG00000128153 ENSMUST00000286010.1 ENSMUSG00000128153 (from geneSymbol) uc333rnd.1 uc333rnd.1 
ENSMUST00000286012.1 ENSMUSG00000128154 ENSMUST00000286012.1 ENSMUSG00000128154 (from geneSymbol) uc333rnf.1 uc333rnf.1 
ENSMUST00000286020.1 ENSMUSG00000128155 ENSMUST00000286020.1 ENSMUSG00000128155 (from geneSymbol) uc333rnn.1 uc333rnn.1 
ENSMUST00000286023.1 ENSMUSG00000128156 ENSMUST00000286023.1 ENSMUSG00000128156 (from geneSymbol) uc333rnq.1 uc333rnq.1 
ENSMUST00000286030.1 ENSMUSG00000128157 ENSMUST00000286030.1 ENSMUSG00000128157 (from geneSymbol) uc333rnx.1 uc333rnx.1 
ENSMUST00000286031.1 ENSMUSG00000128158 ENSMUST00000286031.1 ENSMUSG00000128158 (from geneSymbol) uc333rny.1 uc333rny.1 
ENSMUST00000286033.1 ENSMUSG00000128159 ENSMUST00000286033.1 ENSMUSG00000128159 (from geneSymbol) uc333roa.1 uc333roa.1 
ENSMUST00000286056.1 ENSMUSG00000128160 ENSMUST00000286056.1 ENSMUSG00000128160 (from geneSymbol) uc333rox.1 uc333rox.1 
ENSMUST00000286066.1 ENSMUSG00000128162 ENSMUST00000286066.1 ENSMUSG00000128162 (from geneSymbol) uc333rpg.1 uc333rpg.1 
ENSMUST00000286067.1 ENSMUSG00000128163 ENSMUST00000286067.1 ENSMUSG00000128163 (from geneSymbol) uc333rph.1 uc333rph.1 
ENSMUST00000286080.1 ENSMUSG00000128164 ENSMUST00000286080.1 ENSMUSG00000128164 (from geneSymbol) uc333rpu.1 uc333rpu.1 
ENSMUST00000286081.1 ENSMUSG00000128165 ENSMUST00000286081.1 ENSMUSG00000128165 (from geneSymbol) uc333rpv.1 uc333rpv.1 
ENSMUST00000286082.1 ENSMUSG00000128166 ENSMUST00000286082.1 ENSMUSG00000128166 (from geneSymbol) uc333rpw.1 uc333rpw.1 
ENSMUST00000286083.1 ENSMUSG00000128167 ENSMUST00000286083.1 ENSMUSG00000128167 (from geneSymbol) uc333rpx.1 uc333rpx.1 
ENSMUST00000286087.1 ENSMUSG00000128168 ENSMUST00000286087.1 ENSMUSG00000128168 (from geneSymbol) uc333rpy.1 uc333rpy.1 
ENSMUST00000286088.1 ENSMUSG00000128169 ENSMUST00000286088.1 ENSMUSG00000128169 (from geneSymbol) uc333rpz.1 uc333rpz.1 
ENSMUST00000286089.1 ENSMUSG00000128170 ENSMUST00000286089.1 ENSMUSG00000128170 (from geneSymbol) uc333rqa.1 uc333rqa.1 
ENSMUST00000286096.1 Gm41002 ENSMUST00000286096.1 Gm41002 (from geneSymbol) uc333rqh.1 uc333rqh.1 
ENSMUST00000286107.1 ENSMUSG00000128171 ENSMUST00000286107.1 ENSMUSG00000128171 (from geneSymbol) uc333rqs.1 uc333rqs.1 
ENSMUST00000286108.1 1700016L21Rik ENSMUST00000286108.1 1700016L21Rik (from geneSymbol) AK139674 uc333rqt.1 uc333rqt.1 
ENSMUST00000286164.1 ENSMUSG00000128172 ENSMUST00000286164.1 ENSMUSG00000128172 (from geneSymbol) uc333rsx.1 uc333rsx.1 
ENSMUST00000286166.1 ENSMUSG00000128173 ENSMUST00000286166.1 ENSMUSG00000128173 (from geneSymbol) uc333rsz.1 uc333rsz.1 
ENSMUST00000286167.1 ENSMUSG00000128174 ENSMUST00000286167.1 ENSMUSG00000128174 (from geneSymbol) uc333rta.1 uc333rta.1 
ENSMUST00000286168.1 ENSMUSG00000128175 ENSMUST00000286168.1 ENSMUSG00000128175 (from geneSymbol) uc333rtb.1 uc333rtb.1 
ENSMUST00000286169.1 ENSMUSG00000128176 ENSMUST00000286169.1 ENSMUSG00000128176 (from geneSymbol) uc333rtc.1 uc333rtc.1 
ENSMUST00000286170.1 ENSMUSG00000128177 ENSMUST00000286170.1 ENSMUSG00000128177 (from geneSymbol) uc333rtd.1 uc333rtd.1 
ENSMUST00000286171.1 ENSMUSG00000128178 ENSMUST00000286171.1 ENSMUSG00000128178 (from geneSymbol) uc333rte.1 uc333rte.1 
ENSMUST00000286174.1 ENSMUSG00000128179 ENSMUST00000286174.1 ENSMUSG00000128179 (from geneSymbol) uc333rth.1 uc333rth.1 
ENSMUST00000286179.1 ENSMUSG00000128180 ENSMUST00000286179.1 ENSMUSG00000128180 (from geneSymbol) uc333rtm.1 uc333rtm.1 
ENSMUST00000286180.1 ENSMUSG00000128181 ENSMUST00000286180.1 ENSMUSG00000128181 (from geneSymbol) uc333rtn.1 uc333rtn.1 
ENSMUST00000286181.1 Gm47368 ENSMUST00000286181.1 Gm47368 (from geneSymbol) uc333rto.1 uc333rto.1 
ENSMUST00000286189.1 ENSMUSG00000128182 ENSMUST00000286189.1 ENSMUSG00000128182 (from geneSymbol) uc333rtw.1 uc333rtw.1 
ENSMUST00000286195.1 ENSMUSG00000128183 ENSMUST00000286195.1 ENSMUSG00000128183 (from geneSymbol) uc333ruc.1 uc333ruc.1 
ENSMUST00000286213.1 ENSMUSG00000128184 ENSMUST00000286213.1 ENSMUSG00000128184 (from geneSymbol) uc333ruu.1 uc333ruu.1 
ENSMUST00000286214.1 ENSMUSG00000128185 ENSMUST00000286214.1 ENSMUSG00000128185 (from geneSymbol) uc333ruv.1 uc333ruv.1 
ENSMUST00000286215.1 ENSMUSG00000128186 ENSMUST00000286215.1 ENSMUSG00000128186 (from geneSymbol) uc333ruw.1 uc333ruw.1 
ENSMUST00000286216.1 ENSMUSG00000128187 ENSMUST00000286216.1 ENSMUSG00000128187 (from geneSymbol) uc333rux.1 uc333rux.1 
ENSMUST00000286217.1 ENSMUSG00000128188 ENSMUST00000286217.1 ENSMUSG00000128188 (from geneSymbol) uc333ruy.1 uc333ruy.1 
ENSMUST00000286219.1 ENSMUSG00000128189 ENSMUST00000286219.1 ENSMUSG00000128189 (from geneSymbol) BC089466 uc333rva.1 uc333rva.1 
ENSMUST00000286220.1 ENSMUSG00000128190 ENSMUST00000286220.1 ENSMUSG00000128190 (from geneSymbol) uc333rvb.1 uc333rvb.1 
ENSMUST00000286221.1 ENSMUSG00000128191 ENSMUST00000286221.1 ENSMUSG00000128191 (from geneSymbol) uc333rvc.1 uc333rvc.1 
ENSMUST00000286222.1 ENSMUSG00000128192 ENSMUST00000286222.1 ENSMUSG00000128192 (from geneSymbol) uc333rvd.1 uc333rvd.1 
ENSMUST00000286223.1 ENSMUSG00000128193 ENSMUST00000286223.1 ENSMUSG00000128193 (from geneSymbol) uc333rve.1 uc333rve.1 
ENSMUST00000286224.1 ENSMUSG00000128194 ENSMUST00000286224.1 ENSMUSG00000128194 (from geneSymbol) uc333rvf.1 uc333rvf.1 
ENSMUST00000286227.1 ENSMUSG00000128195 ENSMUST00000286227.1 ENSMUSG00000128195 (from geneSymbol) uc333rvi.1 uc333rvi.1 
ENSMUST00000286229.1 Gm2822 ENSMUST00000286229.1 Gm2822 (from geneSymbol) uc333rvk.1 uc333rvk.1 
ENSMUST00000286233.1 ENSMUSG00000128196 ENSMUST00000286233.1 ENSMUSG00000128196 (from geneSymbol) uc333rvo.1 uc333rvo.1 
ENSMUST00000286234.1 ENSMUSG00000128197 ENSMUST00000286234.1 ENSMUSG00000128197 (from geneSymbol) uc333rvp.1 uc333rvp.1 
ENSMUST00000286235.1 ENSMUSG00000128198 ENSMUST00000286235.1 ENSMUSG00000128198 (from geneSymbol) uc333rvq.1 uc333rvq.1 
ENSMUST00000286238.1 ENSMUSG00000128199 ENSMUST00000286238.1 ENSMUSG00000128199 (from geneSymbol) uc333rvt.1 uc333rvt.1 
ENSMUST00000286239.1 Gm48295 ENSMUST00000286239.1 Gm48295 (from geneSymbol) AK039078 uc333rvu.1 uc333rvu.1 
ENSMUST00000286248.1 Gm42488 ENSMUST00000286248.1 Gm42488 (from geneSymbol) BC072617 uc333rwd.1 uc333rwd.1 
ENSMUST00000286273.1 ENSMUSG00000128200 ENSMUST00000286273.1 ENSMUSG00000128200 (from geneSymbol) uc333rxc.1 uc333rxc.1 
ENSMUST00000286274.1 ENSMUSG00000128201 ENSMUST00000286274.1 ENSMUSG00000128201 (from geneSymbol) AK131823 uc333rxd.1 uc333rxd.1 
ENSMUST00000286278.1 Gm57031 ENSMUST00000286278.1 Gm57031 (from geneSymbol) uc333rxg.1 uc333rxg.1 
ENSMUST00000286284.1 AU020206 ENSMUST00000286284.1 AU020206 (from geneSymbol) KY467450 uc333rxm.1 uc333rxm.1 
ENSMUST00000286293.1 ENSMUSG00000128204 ENSMUST00000286293.1 ENSMUSG00000128204 (from geneSymbol) uc333rxv.1 uc333rxv.1 
ENSMUST00000286294.1 ENSMUSG00000128205 ENSMUST00000286294.1 ENSMUSG00000128205 (from geneSymbol) uc333rxw.1 uc333rxw.1 
ENSMUST00000286300.1 ENSMUSG00000128206 ENSMUST00000286300.1 ENSMUSG00000128206 (from geneSymbol) uc333ryc.1 uc333ryc.1 
ENSMUST00000286301.1 ENSMUSG00000128207 ENSMUST00000286301.1 ENSMUSG00000128207 (from geneSymbol) uc333ryd.1 uc333ryd.1 
ENSMUST00000286302.1 ENSMUSG00000128208 ENSMUST00000286302.1 ENSMUSG00000128208 (from geneSymbol) uc333rye.1 uc333rye.1 
ENSMUST00000286305.1 ENSMUSG00000128209 ENSMUST00000286305.1 ENSMUSG00000128209 (from geneSymbol) AB349884 uc333ryh.1 uc333ryh.1 
ENSMUST00000286306.1 ENSMUSG00000128210 ENSMUST00000286306.1 ENSMUSG00000128210 (from geneSymbol) uc333ryi.1 uc333ryi.1 
ENSMUST00000286320.1 ENSMUSG00000128211 ENSMUST00000286320.1 ENSMUSG00000128211 (from geneSymbol) uc333ryw.1 uc333ryw.1 
ENSMUST00000286322.1 ENSMUSG00000128213 ENSMUST00000286322.1 ENSMUSG00000128213 (from geneSymbol) uc333ryx.1 uc333ryx.1 
ENSMUST00000286324.1 ENSMUSG00000128214 ENSMUST00000286324.1 ENSMUSG00000128214 (from geneSymbol) uc333ryz.1 uc333ryz.1 
ENSMUST00000286325.1 ENSMUSG00000128215 ENSMUST00000286325.1 ENSMUSG00000128215 (from geneSymbol) uc333rza.1 uc333rza.1 
ENSMUST00000286326.1 ENSMUSG00000128216 ENSMUST00000286326.1 ENSMUSG00000128216 (from geneSymbol) uc333rzb.1 uc333rzb.1 
ENSMUST00000286331.1 4930556L07Rik ENSMUST00000286331.1 4930556L07Rik (from geneSymbol) AK016149 uc333rzg.1 uc333rzg.1 
ENSMUST00000286355.1 ENSMUSG00000128217 ENSMUST00000286355.1 ENSMUSG00000128217 (from geneSymbol) uc333sae.1 uc333sae.1 
ENSMUST00000286358.1 ENSMUSG00000128218 ENSMUST00000286358.1 ENSMUSG00000128218 (from geneSymbol) uc333sah.1 uc333sah.1 
ENSMUST00000286361.1 ENSMUSG00000128219 ENSMUST00000286361.1 ENSMUSG00000128219 (from geneSymbol) uc333sak.1 uc333sak.1 
ENSMUST00000286376.1 ENSMUSG00000128220 ENSMUST00000286376.1 ENSMUSG00000128220 (from geneSymbol) uc333saz.1 uc333saz.1 
ENSMUST00000286378.1 ENSMUSG00000128221 ENSMUST00000286378.1 ENSMUSG00000128221 (from geneSymbol) uc333sbb.1 uc333sbb.1 
ENSMUST00000286390.1 ENSMUSG00000128222 ENSMUST00000286390.1 ENSMUSG00000128222 (from geneSymbol) uc333sbn.1 uc333sbn.1 
ENSMUST00000286396.1 ENSMUSG00000128223 ENSMUST00000286396.1 ENSMUSG00000128223 (from geneSymbol) uc333sbt.1 uc333sbt.1 
ENSMUST00000286397.1 ENSMUSG00000128224 ENSMUST00000286397.1 ENSMUSG00000128224 (from geneSymbol) uc333sbu.1 uc333sbu.1 
ENSMUST00000286408.1 ENSMUSG00000128225 ENSMUST00000286408.1 ENSMUSG00000128225 (from geneSymbol) uc333scf.1 uc333scf.1 
ENSMUST00000286410.1 ENSMUSG00000128226 ENSMUST00000286410.1 ENSMUSG00000128226 (from geneSymbol) uc333sch.1 uc333sch.1 
ENSMUST00000286411.1 ENSMUSG00000128227 ENSMUST00000286411.1 ENSMUSG00000128227 (from geneSymbol) uc333sci.1 uc333sci.1 
ENSMUST00000286412.1 ENSMUSG00000128228 ENSMUST00000286412.1 ENSMUSG00000128228 (from geneSymbol) LF199796 uc333scj.1 uc333scj.1 
ENSMUST00000286413.1 ENSMUSG00000128229 ENSMUST00000286413.1 ENSMUSG00000128229 (from geneSymbol) uc333sck.1 uc333sck.1 
ENSMUST00000286415.1 4930594M17Rik ENSMUST00000286415.1 4930594M17Rik (from geneSymbol) AK016392 uc333scm.1 uc333scm.1 
ENSMUST00000286416.1 ENSMUSG00000128230 ENSMUST00000286416.1 ENSMUSG00000128230 (from geneSymbol) uc333scn.1 uc333scn.1 
ENSMUST00000286420.1 ENSMUSG00000128231 ENSMUST00000286420.1 ENSMUSG00000128231 (from geneSymbol) uc333scr.1 uc333scr.1 
ENSMUST00000286427.1 ENSMUSG00000128232 ENSMUST00000286427.1 ENSMUSG00000128232 (from geneSymbol) uc333scy.1 uc333scy.1 
ENSMUST00000286428.1 ENSMUSG00000128233 ENSMUST00000286428.1 ENSMUSG00000128233 (from geneSymbol) uc333scz.1 uc333scz.1 
ENSMUST00000286431.1 ENSMUSG00000128234 ENSMUST00000286431.1 ENSMUSG00000128234 (from geneSymbol) uc333sdc.1 uc333sdc.1 
ENSMUST00000286442.1 ENSMUSG00000128235 ENSMUST00000286442.1 ENSMUSG00000128235 (from geneSymbol) uc333sdn.1 uc333sdn.1 
ENSMUST00000286443.1 ENSMUSG00000128236 ENSMUST00000286443.1 ENSMUSG00000128236 (from geneSymbol) uc333sdo.1 uc333sdo.1 
ENSMUST00000286456.1 1700027J07Rik ENSMUST00000286456.1 1700027J07Rik (from geneSymbol) AK006428 uc333seb.1 uc333seb.1 
ENSMUST00000286468.1 1700066J03Rik ENSMUST00000286468.1 1700066J03Rik (from geneSymbol) AK039557 uc333sen.1 uc333sen.1 
ENSMUST00000286470.1 ENSMUSG00000128237 ENSMUST00000286470.1 ENSMUSG00000128237 (from geneSymbol) uc333sep.1 uc333sep.1 
ENSMUST00000286472.1 ENSMUSG00000128238 ENSMUST00000286472.1 ENSMUSG00000128238 (from geneSymbol) uc333ser.1 uc333ser.1 
ENSMUST00000286473.1 ENSMUSG00000128239 ENSMUST00000286473.1 ENSMUSG00000128239 (from geneSymbol) uc333ses.1 uc333ses.1 
ENSMUST00000286474.1 ENSMUSG00000128240 ENSMUST00000286474.1 ENSMUSG00000128240 (from geneSymbol) uc333set.1 uc333set.1 
ENSMUST00000286475.1 ENSMUSG00000128241 ENSMUST00000286475.1 ENSMUSG00000128241 (from geneSymbol) uc333seu.1 uc333seu.1 
ENSMUST00000286476.1 ENSMUSG00000128242 ENSMUST00000286476.1 ENSMUSG00000128242 (from geneSymbol) uc333sev.1 uc333sev.1 
ENSMUST00000286478.1 ENSMUSG00000128243 ENSMUST00000286478.1 ENSMUSG00000128243 (from geneSymbol) uc333sex.1 uc333sex.1 
ENSMUST00000286479.1 ENSMUSG00000128244 ENSMUST00000286479.1 ENSMUSG00000128244 (from geneSymbol) uc333sey.1 uc333sey.1 
ENSMUST00000286480.1 ENSMUSG00000128245 ENSMUST00000286480.1 ENSMUSG00000128245 (from geneSymbol) uc333sez.1 uc333sez.1 
ENSMUST00000286481.1 ENSMUSG00000128246 ENSMUST00000286481.1 ENSMUSG00000128246 (from geneSymbol) uc333sfa.1 uc333sfa.1 
ENSMUST00000286482.1 ENSMUSG00000128247 ENSMUST00000286482.1 ENSMUSG00000128247 (from geneSymbol) uc333sfb.1 uc333sfb.1 
ENSMUST00000286483.1 ENSMUSG00000128248 ENSMUST00000286483.1 ENSMUSG00000128248 (from geneSymbol) uc333sfc.1 uc333sfc.1 
ENSMUST00000286485.1 ENSMUSG00000128249 ENSMUST00000286485.1 ENSMUSG00000128249 (from geneSymbol) uc333sfe.1 uc333sfe.1 
ENSMUST00000286488.1 ENSMUSG00000128250 ENSMUST00000286488.1 ENSMUSG00000128250 (from geneSymbol) uc333sfh.1 uc333sfh.1 
ENSMUST00000286491.1 Gm13715 ENSMUST00000286491.1 Gm13715 (from geneSymbol) uc333sfk.1 uc333sfk.1 
ENSMUST00000286504.1 ENSMUSG00000128251 ENSMUST00000286504.1 ENSMUSG00000128251 (from geneSymbol) uc333sfx.1 uc333sfx.1 
ENSMUST00000286505.1 ENSMUSG00000128252 ENSMUST00000286505.1 ENSMUSG00000128252 (from geneSymbol) uc333sfy.1 uc333sfy.1 
ENSMUST00000286506.1 ENSMUSG00000128253 ENSMUST00000286506.1 ENSMUSG00000128253 (from geneSymbol) uc333sfz.1 uc333sfz.1 
ENSMUST00000286507.1 5730409N16Rik ENSMUST00000286507.1 5730409N16Rik (from geneSymbol) uc333sga.1 uc333sga.1 
ENSMUST00000286508.1 ENSMUSG00000128254 ENSMUST00000286508.1 ENSMUSG00000128254 (from geneSymbol) uc333sgb.1 uc333sgb.1 
ENSMUST00000286514.1 ENSMUSG00000128255 ENSMUST00000286514.1 ENSMUSG00000128255 (from geneSymbol) uc333sgh.1 uc333sgh.1 
ENSMUST00000286515.1 ENSMUSG00000128256 ENSMUST00000286515.1 ENSMUSG00000128256 (from geneSymbol) uc333sgi.1 uc333sgi.1 
ENSMUST00000286519.1 Gm28694 ENSMUST00000286519.1 Gm28694 (from geneSymbol) uc333sgm.1 uc333sgm.1 
ENSMUST00000286532.1 ENSMUSG00000128257 ENSMUST00000286532.1 ENSMUSG00000128257 (from geneSymbol) FJ541075 uc333sgz.1 uc333sgz.1 
ENSMUST00000286544.1 ENSMUSG00000128258 ENSMUST00000286544.1 ENSMUSG00000128258 (from geneSymbol) uc333shl.1 uc333shl.1 
ENSMUST00000286545.1 ENSMUSG00000128259 ENSMUST00000286545.1 ENSMUSG00000128259 (from geneSymbol) uc333shm.1 uc333shm.1 
ENSMUST00000286548.1 ENSMUSG00000128260 ENSMUST00000286548.1 ENSMUSG00000128260 (from geneSymbol) uc333shp.1 uc333shp.1 
ENSMUST00000286556.1 Mm2pr ENSMUST00000286556.1 Mm2pr (from geneSymbol) AK082086 uc333shx.1 uc333shx.1 
ENSMUST00000286559.1 ENSMUSG00000128261 ENSMUST00000286559.1 ENSMUSG00000128261 (from geneSymbol) uc333sia.1 uc333sia.1 
ENSMUST00000286561.1 Gm49312 ENSMUST00000286561.1 Gm49312 (from geneSymbol) uc333sic.1 uc333sic.1 
ENSMUST00000286569.1 ENSMUSG00000128262 ENSMUST00000286569.1 ENSMUSG00000128262 (from geneSymbol) uc333sik.1 uc333sik.1 
ENSMUST00000286575.1 EU599041 ENSMUST00000286575.1 EU599041 (from geneSymbol) EU599042 uc333siq.1 uc333siq.1 
ENSMUST00000286580.1 ENSMUSG00000128263 ENSMUST00000286580.1 ENSMUSG00000128263 (from geneSymbol) uc333siv.1 uc333siv.1 
ENSMUST00000286581.1 ENSMUSG00000128264 ENSMUST00000286581.1 ENSMUSG00000128264 (from geneSymbol) uc333siw.1 uc333siw.1 
ENSMUST00000286583.1 ENSMUSG00000128265 ENSMUST00000286583.1 ENSMUSG00000128265 (from geneSymbol) uc333siy.1 uc333siy.1 
ENSMUST00000286587.1 ENSMUSG00000128266 ENSMUST00000286587.1 ENSMUSG00000128266 (from geneSymbol) uc333sjc.1 uc333sjc.1 
ENSMUST00000286591.1 ENSMUSG00000128267 ENSMUST00000286591.1 ENSMUSG00000128267 (from geneSymbol) uc333sjf.1 uc333sjf.1 
ENSMUST00000286592.1 ENSMUSG00000128268 ENSMUST00000286592.1 ENSMUSG00000128268 (from geneSymbol) uc333sjg.1 uc333sjg.1 
ENSMUST00000286593.1 ENSMUSG00000128269 ENSMUST00000286593.1 ENSMUSG00000128269 (from geneSymbol) uc333sjh.1 uc333sjh.1 
ENSMUST00000286596.1 ENSMUSG00000128270 ENSMUST00000286596.1 ENSMUSG00000128270 (from geneSymbol) uc333sjk.1 uc333sjk.1 
ENSMUST00000286599.1 ENSMUSG00000128271 ENSMUST00000286599.1 ENSMUSG00000128271 (from geneSymbol) uc333sjn.1 uc333sjn.1 
ENSMUST00000286600.1 ENSMUSG00000128272 ENSMUST00000286600.1 ENSMUSG00000128272 (from geneSymbol) uc333sjo.1 uc333sjo.1 
ENSMUST00000286618.1 ENSMUSG00000128273 ENSMUST00000286618.1 ENSMUSG00000128273 (from geneSymbol) uc333skg.1 uc333skg.1 
ENSMUST00000286619.1 Gm41790 ENSMUST00000286619.1 Gm41790 (from geneSymbol) AK155068 uc333skh.1 uc333skh.1 
ENSMUST00000286624.1 Gm35281 ENSMUST00000286624.1 Gm35281 (from geneSymbol) uc333skm.1 uc333skm.1 
ENSMUST00000286635.1 ENSMUSG00000128274 ENSMUST00000286635.1 ENSMUSG00000128274 (from geneSymbol) uc333skx.1 uc333skx.1 
ENSMUST00000286639.1 ENSMUSG00000128275 ENSMUST00000286639.1 ENSMUSG00000128275 (from geneSymbol) uc333slb.1 uc333slb.1 
ENSMUST00000286641.1 Gm36159 ENSMUST00000286641.1 Gm36159 (from geneSymbol) uc333sld.1 uc333sld.1 
ENSMUST00000286643.1 ENSMUSG00000128276 ENSMUST00000286643.1 ENSMUSG00000128276 (from geneSymbol) uc333slf.1 uc333slf.1 
ENSMUST00000286644.1 ENSMUSG00000128277 ENSMUST00000286644.1 ENSMUSG00000128277 (from geneSymbol) uc333slg.1 uc333slg.1 
ENSMUST00000286645.1 ENSMUSG00000128278 ENSMUST00000286645.1 ENSMUSG00000128278 (from geneSymbol) uc333slh.1 uc333slh.1 
ENSMUST00000286648.1 ENSMUSG00000128279 ENSMUST00000286648.1 ENSMUSG00000128279 (from geneSymbol) uc333slk.1 uc333slk.1 
ENSMUST00000286649.1 ENSMUSG00000128280 ENSMUST00000286649.1 ENSMUSG00000128280 (from geneSymbol) uc333sll.1 uc333sll.1 
ENSMUST00000286650.1 ENSMUSG00000128281 ENSMUST00000286650.1 ENSMUSG00000128281 (from geneSymbol) uc333slm.1 uc333slm.1 
ENSMUST00000286651.1 ENSMUSG00000128282 ENSMUST00000286651.1 ENSMUSG00000128282 (from geneSymbol) uc333sln.1 uc333sln.1 
ENSMUST00000286652.1 ENSMUSG00000128283 ENSMUST00000286652.1 ENSMUSG00000128283 (from geneSymbol) uc333slo.1 uc333slo.1 
ENSMUST00000286654.1 ENSMUSG00000128284 ENSMUST00000286654.1 ENSMUSG00000128284 (from geneSymbol) uc333slq.1 uc333slq.1 
ENSMUST00000286655.1 ENSMUSG00000128285 ENSMUST00000286655.1 ENSMUSG00000128285 (from geneSymbol) uc333slr.1 uc333slr.1 
ENSMUST00000286656.1 ENSMUSG00000128286 ENSMUST00000286656.1 ENSMUSG00000128286 (from geneSymbol) uc333sls.1 uc333sls.1 
ENSMUST00000286659.1 ENSMUSG00000128287 ENSMUST00000286659.1 ENSMUSG00000128287 (from geneSymbol) uc333slv.1 uc333slv.1 
ENSMUST00000286666.1 ENSMUSG00000128288 ENSMUST00000286666.1 ENSMUSG00000128288 (from geneSymbol) uc333smc.1 uc333smc.1 
ENSMUST00000286669.1 ENSMUSG00000128289 ENSMUST00000286669.1 ENSMUSG00000128289 (from geneSymbol) uc333smf.1 uc333smf.1 
ENSMUST00000286671.1 Gm13449 ENSMUST00000286671.1 Gm13449 (from geneSymbol) uc333smh.1 uc333smh.1 
ENSMUST00000286674.1 ENSMUSG00000128290 ENSMUST00000286674.1 ENSMUSG00000128290 (from geneSymbol) uc333smk.1 uc333smk.1 
ENSMUST00000286675.1 ENSMUSG00000128291 ENSMUST00000286675.1 ENSMUSG00000128291 (from geneSymbol) uc333sml.1 uc333sml.1 
ENSMUST00000286681.1 ENSMUSG00000128292 ENSMUST00000286681.1 ENSMUSG00000128292 (from geneSymbol) uc333smr.1 uc333smr.1 
ENSMUST00000286682.1 ENSMUSG00000128293 ENSMUST00000286682.1 ENSMUSG00000128293 (from geneSymbol) uc333sms.1 uc333sms.1 
ENSMUST00000286684.1 ENSMUSG00000128294 ENSMUST00000286684.1 ENSMUSG00000128294 (from geneSymbol) uc333smu.1 uc333smu.1 
ENSMUST00000286694.1 ENSMUSG00000128295 ENSMUST00000286694.1 ENSMUSG00000128295 (from geneSymbol) uc333sne.1 uc333sne.1 
ENSMUST00000286698.1 ENSMUSG00000128296 ENSMUST00000286698.1 ENSMUSG00000128296 (from geneSymbol) uc333sni.1 uc333sni.1 
ENSMUST00000286699.1 ENSMUSG00000128297 ENSMUST00000286699.1 ENSMUSG00000128297 (from geneSymbol) uc333snj.1 uc333snj.1 
ENSMUST00000286700.1 ENSMUSG00000128298 ENSMUST00000286700.1 ENSMUSG00000128298 (from geneSymbol) uc333snk.1 uc333snk.1 
ENSMUST00000286701.1 ENSMUSG00000128299 ENSMUST00000286701.1 ENSMUSG00000128299 (from geneSymbol) uc333snl.1 uc333snl.1 
ENSMUST00000286702.1 ENSMUSG00000128300 ENSMUST00000286702.1 ENSMUSG00000128300 (from geneSymbol) uc333snm.1 uc333snm.1 
ENSMUST00000286705.1 ENSMUSG00000128301 ENSMUST00000286705.1 ENSMUSG00000128301 (from geneSymbol) uc333snp.1 uc333snp.1 
ENSMUST00000286706.1 2610017A05Rik ENSMUST00000286706.1 2610017A05Rik (from geneSymbol) uc333snq.1 uc333snq.1 
ENSMUST00000286713.1 ENSMUSG00000128303 ENSMUST00000286713.1 ENSMUSG00000128303 (from geneSymbol) uc333snx.1 uc333snx.1 
ENSMUST00000286714.1 ENSMUSG00000128304 ENSMUST00000286714.1 ENSMUSG00000128304 (from geneSymbol) uc333sny.1 uc333sny.1 
ENSMUST00000286715.1 Adh6-ps1 ENSMUST00000286715.1 Adh6-ps1 (from geneSymbol) AK004863 uc333snz.1 uc333snz.1 
ENSMUST00000286730.1 ENSMUSG00000128305 ENSMUST00000286730.1 ENSMUSG00000128305 (from geneSymbol) uc333soo.1 uc333soo.1 
ENSMUST00000286734.1 Gm31557 ENSMUST00000286734.1 Gm31557 (from geneSymbol) uc333sos.1 uc333sos.1 
ENSMUST00000286739.1 ENSMUSG00000128306 ENSMUST00000286739.1 ENSMUSG00000128306 (from geneSymbol) uc333sox.1 uc333sox.1 
ENSMUST00000286742.1 ENSMUSG00000128307 ENSMUST00000286742.1 ENSMUSG00000128307 (from geneSymbol) uc333spa.1 uc333spa.1 
ENSMUST00000286743.1 ENSMUSG00000128308 ENSMUST00000286743.1 ENSMUSG00000128308 (from geneSymbol) uc333spb.1 uc333spb.1 
ENSMUST00000286744.1 ENSMUSG00000128309 ENSMUST00000286744.1 ENSMUSG00000128309 (from geneSymbol) uc333spc.1 uc333spc.1 
ENSMUST00000286745.1 ENSMUSG00000128310 ENSMUST00000286745.1 ENSMUSG00000128310 (from geneSymbol) uc333spd.1 uc333spd.1 
ENSMUST00000286753.1 ENSMUSG00000128311 ENSMUST00000286753.1 ENSMUSG00000128311 (from geneSymbol) uc333spk.1 uc333spk.1 
ENSMUST00000286757.1 ENSMUSG00000128312 ENSMUST00000286757.1 ENSMUSG00000128312 (from geneSymbol) uc333spo.1 uc333spo.1 
ENSMUST00000286758.1 ENSMUSG00000128313 ENSMUST00000286758.1 ENSMUSG00000128313 (from geneSymbol) uc333spp.1 uc333spp.1 
ENSMUST00000286771.1 ENSMUSG00000128315 ENSMUST00000286771.1 ENSMUSG00000128315 (from geneSymbol) uc333sqb.1 uc333sqb.1 
ENSMUST00000286772.1 ENSMUSG00000128316 ENSMUST00000286772.1 ENSMUSG00000128316 (from geneSymbol) uc333sqc.1 uc333sqc.1 
ENSMUST00000286774.1 ENSMUSG00000128317 ENSMUST00000286774.1 ENSMUSG00000128317 (from geneSymbol) uc333sqe.1 uc333sqe.1 
ENSMUST00000286788.1 A230087F16Rik ENSMUST00000286788.1 A230087F16Rik (from geneSymbol) AK034445 uc333sqs.1 uc333sqs.1 
ENSMUST00000286797.1 ENSMUSG00000128318 ENSMUST00000286797.1 ENSMUSG00000128318 (from geneSymbol) uc333srb.1 uc333srb.1 
ENSMUST00000286798.1 ENSMUSG00000128319 ENSMUST00000286798.1 ENSMUSG00000128319 (from geneSymbol) uc333src.1 uc333src.1 
ENSMUST00000286799.1 ENSMUSG00000128320 ENSMUST00000286799.1 ENSMUSG00000128320 (from geneSymbol) uc333srd.1 uc333srd.1 
ENSMUST00000286800.1 ENSMUSG00000128321 ENSMUST00000286800.1 ENSMUSG00000128321 (from geneSymbol) uc333sre.1 uc333sre.1 
ENSMUST00000286810.1 ENSMUSG00000128322 ENSMUST00000286810.1 ENSMUSG00000128322 (from geneSymbol) AK016105 uc333sro.1 uc333sro.1 
ENSMUST00000286812.1 ENSMUSG00000128324 ENSMUST00000286812.1 ENSMUSG00000128324 (from geneSymbol) uc333srp.1 uc333srp.1 
ENSMUST00000286814.1 ENSMUSG00000128325 ENSMUST00000286814.1 ENSMUSG00000128325 (from geneSymbol) uc333srr.1 uc333srr.1 
ENSMUST00000286820.1 Gm49980 ENSMUST00000286820.1 Gm49980 (from geneSymbol) uc333srx.1 uc333srx.1 
ENSMUST00000286824.1 ENSMUSG00000128326 ENSMUST00000286824.1 ENSMUSG00000128326 (from geneSymbol) uc333ssb.1 uc333ssb.1 
ENSMUST00000286825.1 ENSMUSG00000128327 ENSMUST00000286825.1 ENSMUSG00000128327 (from geneSymbol) uc333ssc.1 uc333ssc.1 
ENSMUST00000286826.1 Gm57428 ENSMUST00000286826.1 Gm57428 (from geneSymbol) uc333ssd.1 uc333ssd.1 
ENSMUST00000286845.1 ENSMUSG00000128328 ENSMUST00000286845.1 ENSMUSG00000128328 (from geneSymbol) uc333ssw.1 uc333ssw.1 
ENSMUST00000286852.1 ENSMUSG00000128329 ENSMUST00000286852.1 ENSMUSG00000128329 (from geneSymbol) uc333std.1 uc333std.1 
ENSMUST00000286855.1 Gm44644 ENSMUST00000286855.1 Gm44644 (from geneSymbol) AK086730 uc333stg.1 uc333stg.1 
ENSMUST00000286868.1 Gm30498 ENSMUST00000286868.1 Gm30498 (from geneSymbol) BC049705 uc333stt.1 uc333stt.1 
ENSMUST00000286870.1 ENSMUSG00000128330 ENSMUST00000286870.1 ENSMUSG00000128330 (from geneSymbol) uc333stv.1 uc333stv.1 
ENSMUST00000286872.1 ENSMUSG00000128331 ENSMUST00000286872.1 ENSMUSG00000128331 (from geneSymbol) uc333stx.1 uc333stx.1 
ENSMUST00000286873.1 ENSMUSG00000128332 ENSMUST00000286873.1 ENSMUSG00000128332 (from geneSymbol) uc333sty.1 uc333sty.1 
ENSMUST00000286874.1 Gm12239 ENSMUST00000286874.1 Gm12239 (from geneSymbol) AK138581 uc333stz.1 uc333stz.1 
ENSMUST00000286880.1 ENSMUSG00000128333 ENSMUST00000286880.1 ENSMUSG00000128333 (from geneSymbol) uc333suf.1 uc333suf.1 
ENSMUST00000286881.1 ENSMUSG00000128334 ENSMUST00000286881.1 ENSMUSG00000128334 (from geneSymbol) uc333sug.1 uc333sug.1 
ENSMUST00000286883.1 ENSMUSG00000128335 ENSMUST00000286883.1 ENSMUSG00000128335 (from geneSymbol) uc333sui.1 uc333sui.1 
ENSMUST00000286885.1 ENSMUSG00000128336 ENSMUST00000286885.1 ENSMUSG00000128336 (from geneSymbol) uc333suk.1 uc333suk.1 
ENSMUST00000286886.1 Gm35167 ENSMUST00000286886.1 Gm35167 (from geneSymbol) uc333sul.1 uc333sul.1 
ENSMUST00000286889.1 ENSMUSG00000128337 ENSMUST00000286889.1 ENSMUSG00000128337 (from geneSymbol) uc333suo.1 uc333suo.1 
ENSMUST00000286891.1 ENSMUSG00000128338 ENSMUST00000286891.1 ENSMUSG00000128338 (from geneSymbol) uc333suq.1 uc333suq.1 
ENSMUST00000286894.1 ENSMUSG00000128339 ENSMUST00000286894.1 ENSMUSG00000128339 (from geneSymbol) uc333sut.1 uc333sut.1 
ENSMUST00000286898.1 ENSMUSG00000128340 ENSMUST00000286898.1 ENSMUSG00000128340 (from geneSymbol) uc333sux.1 uc333sux.1 
ENSMUST00000286900.1 ENSMUSG00000128341 ENSMUST00000286900.1 ENSMUSG00000128341 (from geneSymbol) uc333suz.1 uc333suz.1 
ENSMUST00000286917.1 ENSMUSG00000128342 ENSMUST00000286917.1 ENSMUSG00000128342 (from geneSymbol) uc333svq.1 uc333svq.1 
ENSMUST00000286960.1 ENSMUSG00000128343 ENSMUST00000286960.1 ENSMUSG00000128343 (from geneSymbol) uc333sxh.1 uc333sxh.1 
ENSMUST00000286961.1 ENSMUSG00000128344 ENSMUST00000286961.1 ENSMUSG00000128344 (from geneSymbol) uc333sxi.1 uc333sxi.1 
ENSMUST00000286982.1 ENSMUSG00000128345 ENSMUST00000286982.1 ENSMUSG00000128345 (from geneSymbol) uc333sxl.1 uc333sxl.1 
ENSMUST00000286983.1 Gm12979 ENSMUST00000286983.1 Gm12979 (from geneSymbol) uc333sxm.1 uc333sxm.1 
ENSMUST00000286988.1 ENSMUSG00000128346 ENSMUST00000286988.1 ENSMUSG00000128346 (from geneSymbol) uc333sxr.1 uc333sxr.1 
ENSMUST00000286989.1 ENSMUSG00000128347 ENSMUST00000286989.1 ENSMUSG00000128347 (from geneSymbol) uc333sxs.1 uc333sxs.1 
ENSMUST00000286990.1 ENSMUSG00000128348 ENSMUST00000286990.1 ENSMUSG00000128348 (from geneSymbol) uc333sxt.1 uc333sxt.1 
ENSMUST00000287008.1 ENSMUSG00000128349 ENSMUST00000287008.1 ENSMUSG00000128349 (from geneSymbol) uc333syl.1 uc333syl.1 
ENSMUST00000287012.1 ENSMUSG00000128350 ENSMUST00000287012.1 ENSMUSG00000128350 (from geneSymbol) uc333syp.1 uc333syp.1 
ENSMUST00000287013.1 ENSMUSG00000128351 ENSMUST00000287013.1 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. (from UniProt J7PCH3) Ifgga5 J7PCH3 J7PCH3_MOUSE uc333syq.1 Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. GTP binding membrane uc333syq.1 
ENSMUST00000287014.1 ENSMUSG00000128352 ENSMUST00000287014.1 ENSMUSG00000128352 (from geneSymbol) uc333syr.1 uc333syr.1 
ENSMUST00000287016.1 ENSMUSG00000128353 ENSMUST00000287016.1 ENSMUSG00000128353 (from geneSymbol) uc333syt.1 uc333syt.1 
ENSMUST00000287022.1 ENSMUSG00000128354 ENSMUST00000287022.1 ENSMUSG00000128354 (from geneSymbol) uc333syz.1 uc333syz.1 
ENSMUST00000287023.1 ENSMUSG00000128355 ENSMUST00000287023.1 ENSMUSG00000128355 (from geneSymbol) uc333sza.1 uc333sza.1 
ENSMUST00000287026.1 ENSMUSG00000128356 ENSMUST00000287026.1 ENSMUSG00000128356 (from geneSymbol) uc333szd.1 uc333szd.1 
ENSMUST00000287027.1 ENSMUSG00000128357 ENSMUST00000287027.1 ENSMUSG00000128357 (from geneSymbol) uc333sze.1 uc333sze.1 
ENSMUST00000287028.1 ENSMUSG00000128358 ENSMUST00000287028.1 ENSMUSG00000128358 (from geneSymbol) uc333szf.1 uc333szf.1 
ENSMUST00000287029.1 ENSMUSG00000128359 ENSMUST00000287029.1 ENSMUSG00000128359 (from geneSymbol) uc333szg.1 uc333szg.1 
ENSMUST00000287055.1 1700113B09Rik ENSMUST00000287055.1 1700113B09Rik (from geneSymbol) AK018958 uc333tag.1 uc333tag.1 
ENSMUST00000287061.1 ENSMUSG00000128360 ENSMUST00000287061.1 ENSMUSG00000128360 (from geneSymbol) uc333tam.1 uc333tam.1 
ENSMUST00000287063.1 ENSMUSG00000128361 ENSMUST00000287063.1 ENSMUSG00000128361 (from geneSymbol) uc333tao.1 uc333tao.1 
ENSMUST00000287071.1 ENSMUSG00000128362 ENSMUST00000287071.1 ENSMUSG00000128362 (from geneSymbol) uc333taw.1 uc333taw.1 
ENSMUST00000287072.1 ENSMUSG00000128363 ENSMUST00000287072.1 ENSMUSG00000128363 (from geneSymbol) uc333tax.1 uc333tax.1 
ENSMUST00000287074.1 ENSMUSG00000128364 ENSMUST00000287074.1 ENSMUSG00000128364 (from geneSymbol) uc333taz.1 uc333taz.1 
ENSMUST00000287075.1 Gm39271 ENSMUST00000287075.1 Gm39271 (from geneSymbol) NR_190389 uc333tba.1 uc333tba.1 
ENSMUST00000287077.1 ENSMUSG00000128365 ENSMUST00000287077.1 ENSMUSG00000128365 (from geneSymbol) uc333tbc.1 uc333tbc.1 
ENSMUST00000287078.1 ENSMUSG00000128366 ENSMUST00000287078.1 ENSMUSG00000128366 (from geneSymbol) uc333tbd.1 uc333tbd.1 
ENSMUST00000287079.1 ENSMUSG00000128367 ENSMUST00000287079.1 ENSMUSG00000128367 (from geneSymbol) uc333tbe.1 uc333tbe.1 
ENSMUST00000287081.1 ENSMUSG00000128368 ENSMUST00000287081.1 ENSMUSG00000128368 (from geneSymbol) uc333tbg.1 uc333tbg.1 
ENSMUST00000287083.1 ENSMUSG00000128369 ENSMUST00000287083.1 ENSMUSG00000128369 (from geneSymbol) uc333tbi.1 uc333tbi.1 
ENSMUST00000287091.1 ENSMUSG00000128370 ENSMUST00000287091.1 ENSMUSG00000128370 (from geneSymbol) uc333tbq.1 uc333tbq.1 
ENSMUST00000287117.1 ENSMUSG00000128371 ENSMUST00000287117.1 ENSMUSG00000128371 (from geneSymbol) uc333tcq.1 uc333tcq.1 
ENSMUST00000287120.1 Gm49984 ENSMUST00000287120.1 Gm49984 (from geneSymbol) AK077708 uc333tct.1 uc333tct.1 
ENSMUST00000287124.1 ENSMUSG00000128372 ENSMUST00000287124.1 ENSMUSG00000128372 (from geneSymbol) uc333tcx.1 uc333tcx.1 
ENSMUST00000287132.1 ENSMUSG00000128373 ENSMUST00000287132.1 ENSMUSG00000128373 (from geneSymbol) uc333tdf.1 uc333tdf.1 
ENSMUST00000287133.1 ENSMUSG00000128374 ENSMUST00000287133.1 ENSMUSG00000128374 (from geneSymbol) uc333tdg.1 uc333tdg.1 
ENSMUST00000287134.1 ENSMUSG00000128375 ENSMUST00000287134.1 ENSMUSG00000128375 (from geneSymbol) uc333tdh.1 uc333tdh.1 
ENSMUST00000287135.1 ENSMUSG00000128376 ENSMUST00000287135.1 ENSMUSG00000128376 (from geneSymbol) uc333tdi.1 uc333tdi.1 
ENSMUST00000287136.1 ENSMUSG00000128377 ENSMUST00000287136.1 ENSMUSG00000128377 (from geneSymbol) uc333tdj.1 uc333tdj.1 
ENSMUST00000287137.1 ENSMUSG00000128378 ENSMUST00000287137.1 ENSMUSG00000128378 (from geneSymbol) uc333tdk.1 uc333tdk.1 
ENSMUST00000287139.1 Kbtbd8os ENSMUST00000287139.1 Kbtbd8os (from geneSymbol) AK005835 uc333tdm.1 uc333tdm.1 
ENSMUST00000287142.1 ENSMUSG00000128379 ENSMUST00000287142.1 ENSMUSG00000128379 (from geneSymbol) uc333tdp.1 uc333tdp.1 
ENSMUST00000287143.1 ENSMUSG00000128380 ENSMUST00000287143.1 ENSMUSG00000128380 (from geneSymbol) uc333tdq.1 uc333tdq.1 
ENSMUST00000287145.1 F730016J06Rik ENSMUST00000287145.1 F730016J06Rik (from geneSymbol) AK036396 uc333tds.1 uc333tds.1 
ENSMUST00000287153.1 Gm57098 ENSMUST00000287153.1 Gm57098 (from geneSymbol) uc333tdz.1 uc333tdz.1 
ENSMUST00000287164.1 ENSMUSG00000128381 ENSMUST00000287164.1 ENSMUSG00000128381 (from geneSymbol) uc333tek.1 uc333tek.1 
ENSMUST00000287166.1 ENSMUSG00000128382 ENSMUST00000287166.1 ENSMUSG00000128382 (from geneSymbol) uc333tem.1 uc333tem.1 
ENSMUST00000287168.1 ENSMUSG00000128383 ENSMUST00000287168.1 ENSMUSG00000128383 (from geneSymbol) uc333teo.1 uc333teo.1 
ENSMUST00000287169.1 ENSMUSG00000128384 ENSMUST00000287169.1 ENSMUSG00000128384 (from geneSymbol) uc333tep.1 uc333tep.1 
ENSMUST00000287170.1 Gm47013 ENSMUST00000287170.1 Gm47013 (from geneSymbol) uc333teq.1 uc333teq.1 
ENSMUST00000287180.1 ENSMUSG00000128386 ENSMUST00000287180.1 ENSMUSG00000128386 (from geneSymbol) uc333tez.1 uc333tez.1 
ENSMUST00000287181.1 ENSMUSG00000128387 ENSMUST00000287181.1 ENSMUSG00000128387 (from geneSymbol) uc333tfa.1 uc333tfa.1 
ENSMUST00000287185.1 1700018P22Rik ENSMUST00000287185.1 1700018P22Rik (from geneSymbol) AK006100 uc333tfe.1 uc333tfe.1 
ENSMUST00000287200.1 ENSMUSG00000128388 ENSMUST00000287200.1 ENSMUSG00000128388 (from geneSymbol) uc333tft.1 uc333tft.1 
ENSMUST00000287201.1 ENSMUSG00000128389 ENSMUST00000287201.1 ENSMUSG00000128389 (from geneSymbol) uc333tfu.1 uc333tfu.1 
ENSMUST00000287202.1 ENSMUSG00000128390 ENSMUST00000287202.1 ENSMUSG00000128390 (from geneSymbol) uc333tfv.1 uc333tfv.1 
ENSMUST00000287203.1 ENSMUSG00000128391 ENSMUST00000287203.1 ENSMUSG00000128391 (from geneSymbol) uc333tfw.1 uc333tfw.1 
ENSMUST00000287205.1 Gm57120 ENSMUST00000287205.1 Gm57120 (from geneSymbol) KY467517 uc333tfy.1 uc333tfy.1 
ENSMUST00000287217.1 ENSMUSG00000128392 ENSMUST00000287217.1 ENSMUSG00000128392 (from geneSymbol) uc333tgk.1 uc333tgk.1 
ENSMUST00000287222.1 ENSMUSG00000128393 ENSMUST00000287222.1 ENSMUSG00000128393 (from geneSymbol) AK163992 uc333tgp.1 uc333tgp.1 
ENSMUST00000287228.1 4930423D24Rik ENSMUST00000287228.1 4930423D24Rik (from geneSymbol) AK015188 uc333tgv.1 uc333tgv.1 
ENSMUST00000287240.1 AI480526 ENSMUST00000287240.1 AI480526 (from geneSymbol) KY468068 uc333thh.1 uc333thh.1 
ENSMUST00000287291.1 ENSMUSG00000128394 ENSMUST00000287291.1 ENSMUSG00000128394 (from geneSymbol) uc333tjg.1 uc333tjg.1 
ENSMUST00000287466.1 ENSMUSG00000128395 ENSMUST00000287466.1 ENSMUSG00000128395 (from geneSymbol) uc333tpz.1 uc333tpz.1 
ENSMUST00000287468.1 ENSMUSG00000128396 ENSMUST00000287468.1 ENSMUSG00000128396 (from geneSymbol) uc333tqb.1 uc333tqb.1 
ENSMUST00000287469.1 ENSMUSG00000128397 ENSMUST00000287469.1 ENSMUSG00000128397 (from geneSymbol) uc333tqc.1 uc333tqc.1 
ENSMUST00000287473.1 ENSMUSG00000128398 ENSMUST00000287473.1 ENSMUSG00000128398 (from geneSymbol) uc333tqg.1 uc333tqg.1 
ENSMUST00000287482.1 2310014F06Rik ENSMUST00000287482.1 2310014F06Rik (from geneSymbol) AK046490 uc333tqp.1 uc333tqp.1 
ENSMUST00000287519.1 ENSMUSG00000128399 ENSMUST00000287519.1 ENSMUSG00000128399 (from geneSymbol) uc333tsa.1 uc333tsa.1 
ENSMUST00000287521.1 ENSMUSG00000128400 ENSMUST00000287521.1 ENSMUSG00000128400 (from geneSymbol) uc333tsc.1 uc333tsc.1 
ENSMUST00000287533.1 ENSMUSG00000128401 ENSMUST00000287533.1 ENSMUSG00000128401 (from geneSymbol) AK007095 uc333tso.1 uc333tso.1 
ENSMUST00000287540.1 4930500L23Rik ENSMUST00000287540.1 4930500L23Rik (from geneSymbol) AK015668 uc333tsu.1 uc333tsu.1 
ENSMUST00000287554.1 ENSMUSG00000128402 ENSMUST00000287554.1 ENSMUSG00000128402 (from geneSymbol) uc333tti.1 uc333tti.1 
ENSMUST00000287555.1 ENSMUSG00000128403 ENSMUST00000287555.1 ENSMUSG00000128403 (from geneSymbol) uc333ttj.1 uc333ttj.1 
ENSMUST00000287557.1 ENSMUSG00000128404 ENSMUST00000287557.1 ENSMUSG00000128404 (from geneSymbol) uc333ttl.1 uc333ttl.1 
ENSMUST00000287560.1 ENSMUSG00000128405 ENSMUST00000287560.1 ENSMUSG00000128405 (from geneSymbol) uc333tto.1 uc333tto.1 
ENSMUST00000287561.1 ENSMUSG00000128406 ENSMUST00000287561.1 ENSMUSG00000128406 (from geneSymbol) uc333ttp.1 uc333ttp.1 
ENSMUST00000287576.1 ENSMUSG00000128407 ENSMUST00000287576.1 ENSMUSG00000128407 (from geneSymbol) uc333tue.1 uc333tue.1 
ENSMUST00000287582.1 ENSMUSG00000128408 ENSMUST00000287582.1 ENSMUSG00000128408 (from geneSymbol) uc333tui.1 uc333tui.1 
ENSMUST00000287585.1 ENSMUSG00000128409 ENSMUST00000287585.1 ENSMUSG00000128409 (from geneSymbol) uc333tul.1 uc333tul.1 
ENSMUST00000287586.1 ENSMUSG00000128410 ENSMUST00000287586.1 ENSMUSG00000128410 (from geneSymbol) uc333tum.1 uc333tum.1 
ENSMUST00000287587.1 ENSMUSG00000128411 ENSMUST00000287587.1 ENSMUSG00000128411 (from geneSymbol) LF200226 uc333tun.1 uc333tun.1 
ENSMUST00000287589.1 Gm56557 ENSMUST00000287589.1 Gm56557 (from geneSymbol) uc333tup.1 uc333tup.1 
ENSMUST00000287602.1 ENSMUSG00000128412 ENSMUST00000287602.1 ENSMUSG00000128412 (from geneSymbol) uc333tvc.1 uc333tvc.1 
ENSMUST00000287603.1 Gm30524 ENSMUST00000287603.1 Gm30524 (from geneSymbol) AK081271 uc333tvd.1 uc333tvd.1 
ENSMUST00000287610.1 Gm13371 ENSMUST00000287610.1 Gm13371 (from geneSymbol) KY467840 uc333tvk.1 uc333tvk.1 
ENSMUST00000287615.1 ENSMUSG00000128413 ENSMUST00000287615.1 ENSMUSG00000128413 (from geneSymbol) uc333tvp.1 uc333tvp.1 
ENSMUST00000287617.1 ENSMUSG00000128414 ENSMUST00000287617.1 ENSMUSG00000128414 (from geneSymbol) uc333tvr.1 uc333tvr.1 
ENSMUST00000287618.1 ENSMUSG00000128415 ENSMUST00000287618.1 ENSMUSG00000128415 (from geneSymbol) uc333tvs.1 uc333tvs.1 
ENSMUST00000287619.1 ENSMUSG00000128416 ENSMUST00000287619.1 ENSMUSG00000128416 (from geneSymbol) uc333tvt.1 uc333tvt.1 
ENSMUST00000287622.1 ENSMUSG00000128417 ENSMUST00000287622.1 ENSMUSG00000128417 (from geneSymbol) uc333tvw.1 uc333tvw.1 
ENSMUST00000287632.1 ENSMUSG00000128418 ENSMUST00000287632.1 ENSMUSG00000128418 (from geneSymbol) uc333twg.1 uc333twg.1 
ENSMUST00000287633.1 ENSMUSG00000128419 ENSMUST00000287633.1 ENSMUSG00000128419 (from geneSymbol) uc333twh.1 uc333twh.1 
ENSMUST00000287653.1 ENSMUSG00000128420 ENSMUST00000287653.1 ENSMUSG00000128420 (from geneSymbol) uc333txb.1 uc333txb.1 
ENSMUST00000287662.1 ENSMUSG00000128421 ENSMUST00000287662.1 ENSMUSG00000128421 (from geneSymbol) uc333txk.1 uc333txk.1 
ENSMUST00000287665.1 Gm57268 ENSMUST00000287665.1 Gm57268 (from geneSymbol) uc333txn.1 uc333txn.1 
ENSMUST00000287670.1 ENSMUSG00000128422 ENSMUST00000287670.1 ENSMUSG00000128422 (from geneSymbol) uc333txs.1 uc333txs.1 
ENSMUST00000287675.1 ENSMUSG00000128423 ENSMUST00000287675.1 ENSMUSG00000128423 (from geneSymbol) uc333txx.1 uc333txx.1 
ENSMUST00000287677.1 ENSMUSG00000128424 ENSMUST00000287677.1 ENSMUSG00000128424 (from geneSymbol) uc333txy.1 uc333txy.1 
ENSMUST00000287678.1 ENSMUSG00000128425 ENSMUST00000287678.1 ENSMUSG00000128425 (from geneSymbol) uc333txz.1 uc333txz.1 
ENSMUST00000287680.1 ENSMUSG00000128426 ENSMUST00000287680.1 ENSMUSG00000128426 (from geneSymbol) uc333tyb.1 uc333tyb.1 
ENSMUST00000287682.1 ENSMUSG00000128427 ENSMUST00000287682.1 ENSMUSG00000128427 (from geneSymbol) uc333tyd.1 uc333tyd.1 
ENSMUST00000287685.1 ENSMUSG00000128428 ENSMUST00000287685.1 ENSMUSG00000128428 (from geneSymbol) uc333tyg.1 uc333tyg.1 
ENSMUST00000287686.1 ENSMUSG00000128429 ENSMUST00000287686.1 ENSMUSG00000128429 (from geneSymbol) uc333tyh.1 uc333tyh.1 
ENSMUST00000287689.1 ENSMUSG00000128430 ENSMUST00000287689.1 ENSMUSG00000128430 (from geneSymbol) uc333tyk.1 uc333tyk.1 
ENSMUST00000287690.1 ENSMUSG00000128431 ENSMUST00000287690.1 ENSMUSG00000128431 (from geneSymbol) uc333tyl.1 uc333tyl.1 
ENSMUST00000287692.1 ENSMUSG00000128432 ENSMUST00000287692.1 ENSMUSG00000128432 (from geneSymbol) uc333tyn.1 uc333tyn.1 
ENSMUST00000287694.1 ENSMUSG00000128433 ENSMUST00000287694.1 ENSMUSG00000128433 (from geneSymbol) uc333typ.1 uc333typ.1 
ENSMUST00000287715.1 ENSMUSG00000128434 ENSMUST00000287715.1 ENSMUSG00000128434 (from geneSymbol) uc333tzk.1 uc333tzk.1 
ENSMUST00000287724.1 ENSMUSG00000128435 ENSMUST00000287724.1 ENSMUSG00000128435 (from geneSymbol) uc333tzt.1 uc333tzt.1 
ENSMUST00000287730.1 ENSMUSG00000128436 ENSMUST00000287730.1 ENSMUSG00000128436 (from geneSymbol) uc333tzz.1 uc333tzz.1 
ENSMUST00000287743.1 ENSMUSG00000128437 ENSMUST00000287743.1 ENSMUSG00000128437 (from geneSymbol) uc333uam.1 uc333uam.1 
ENSMUST00000287744.1 ENSMUSG00000128438 ENSMUST00000287744.1 ENSMUSG00000128438 (from geneSymbol) uc333uan.1 uc333uan.1 
ENSMUST00000287746.1 ENSMUSG00000128439 ENSMUST00000287746.1 ENSMUSG00000128439 (from geneSymbol) uc333uap.1 uc333uap.1 
ENSMUST00000287748.1 ENSMUSG00000128440 ENSMUST00000287748.1 ENSMUSG00000128440 (from geneSymbol) uc333uar.1 uc333uar.1 
ENSMUST00000287756.1 ENSMUSG00000128441 ENSMUST00000287756.1 ENSMUSG00000128441 (from geneSymbol) uc333uaz.1 uc333uaz.1 
ENSMUST00000287757.1 ENSMUSG00000128442 ENSMUST00000287757.1 ENSMUSG00000128442 (from geneSymbol) uc333uba.1 uc333uba.1 
ENSMUST00000287759.1 ENSMUSG00000128443 ENSMUST00000287759.1 ENSMUSG00000128443 (from geneSymbol) uc333ubc.1 uc333ubc.1 
ENSMUST00000287760.1 ENSMUSG00000128444 ENSMUST00000287760.1 ENSMUSG00000128444 (from geneSymbol) uc333ubd.1 uc333ubd.1 
ENSMUST00000287761.1 ENSMUSG00000128445 ENSMUST00000287761.1 ENSMUSG00000128445 (from geneSymbol) uc333ube.1 uc333ube.1 
ENSMUST00000287765.1 ENSMUSG00000128446 ENSMUST00000287765.1 ENSMUSG00000128446 (from geneSymbol) uc333ubi.1 uc333ubi.1 
ENSMUST00000287767.1 ENSMUSG00000128447 ENSMUST00000287767.1 ENSMUSG00000128447 (from geneSymbol) uc333ubk.1 uc333ubk.1 
ENSMUST00000287769.1 ENSMUSG00000128448 ENSMUST00000287769.1 ENSMUSG00000128448 (from geneSymbol) uc333ubm.1 uc333ubm.1 
ENSMUST00000287788.1 ENSMUSG00000128449 ENSMUST00000287788.1 ENSMUSG00000128449 (from geneSymbol) uc333ucf.1 uc333ucf.1 
ENSMUST00000287789.1 ENSMUSG00000128450 ENSMUST00000287789.1 ENSMUSG00000128450 (from geneSymbol) uc333ucg.1 uc333ucg.1 
ENSMUST00000287791.1 ENSMUSG00000128451 ENSMUST00000287791.1 ENSMUSG00000128451 (from geneSymbol) uc333uci.1 uc333uci.1 
ENSMUST00000287794.1 ENSMUSG00000128452 ENSMUST00000287794.1 ENSMUSG00000128452 (from geneSymbol) uc333ucl.1 uc333ucl.1 
ENSMUST00000287795.1 ENSMUSG00000128453 ENSMUST00000287795.1 ENSMUSG00000128453 (from geneSymbol) uc333ucm.1 uc333ucm.1 
ENSMUST00000287796.1 ENSMUSG00000128454 ENSMUST00000287796.1 ENSMUSG00000128454 (from geneSymbol) uc333ucn.1 uc333ucn.1 
ENSMUST00000287797.1 ENSMUSG00000128455 ENSMUST00000287797.1 ENSMUSG00000128455 (from geneSymbol) uc333uco.1 uc333uco.1 
ENSMUST00000287800.1 ENSMUSG00000128456 ENSMUST00000287800.1 ENSMUSG00000128456 (from geneSymbol) uc333ucr.1 uc333ucr.1 
ENSMUST00000287810.1 ENSMUSG00000128457 ENSMUST00000287810.1 ENSMUSG00000128457 (from geneSymbol) uc333udb.1 uc333udb.1 
ENSMUST00000287811.1 ENSMUSG00000128458 ENSMUST00000287811.1 ENSMUSG00000128458 (from geneSymbol) uc333udc.1 uc333udc.1 
ENSMUST00000287812.1 ENSMUSG00000128459 ENSMUST00000287812.1 ENSMUSG00000128459 (from geneSymbol) uc333udd.1 uc333udd.1 
ENSMUST00000287816.1 Gm47020 ENSMUST00000287816.1 Gm47020 (from geneSymbol) uc333udh.1 uc333udh.1 
ENSMUST00000287817.1 ENSMUSG00000128460 ENSMUST00000287817.1 ENSMUSG00000128460 (from geneSymbol) uc333udi.1 uc333udi.1 
ENSMUST00000287818.1 ENSMUSG00000128461 ENSMUST00000287818.1 ENSMUSG00000128461 (from geneSymbol) uc333udj.1 uc333udj.1 
ENSMUST00000287819.1 ENSMUSG00000128462 ENSMUST00000287819.1 ENSMUSG00000128462 (from geneSymbol) uc333udk.1 uc333udk.1 
ENSMUST00000287826.1 ENSMUSG00000128463 ENSMUST00000287826.1 ENSMUSG00000128463 (from geneSymbol) uc333udr.1 uc333udr.1 
ENSMUST00000287827.1 ENSMUSG00000128464 ENSMUST00000287827.1 ENSMUSG00000128464 (from geneSymbol) uc333uds.1 uc333uds.1 
ENSMUST00000287832.1 ENSMUSG00000128465 ENSMUST00000287832.1 ENSMUSG00000128465 (from geneSymbol) uc333udx.1 uc333udx.1 
ENSMUST00000287833.1 ENSMUSG00000128466 ENSMUST00000287833.1 ENSMUSG00000128466 (from geneSymbol) LF193677 uc333udy.1 uc333udy.1 
ENSMUST00000287834.1 ENSMUSG00000128467 ENSMUST00000287834.1 ENSMUSG00000128467 (from geneSymbol) uc333udz.1 uc333udz.1 
ENSMUST00000287836.1 ENSMUSG00000128468 ENSMUST00000287836.1 ENSMUSG00000128468 (from geneSymbol) uc333ueb.1 uc333ueb.1 
ENSMUST00000287837.1 ENSMUSG00000128469 ENSMUST00000287837.1 ENSMUSG00000128469 (from geneSymbol) uc333uec.1 uc333uec.1 
ENSMUST00000287839.1 ENSMUSG00000128470 ENSMUST00000287839.1 ENSMUSG00000128470 (from geneSymbol) uc333uee.1 uc333uee.1 
ENSMUST00000287842.1 ENSMUSG00000128471 ENSMUST00000287842.1 ENSMUSG00000128471 (from geneSymbol) uc333ueh.1 uc333ueh.1 
ENSMUST00000287854.1 ENSMUSG00000128472 ENSMUST00000287854.1 ENSMUSG00000128472 (from geneSymbol) uc333uet.1 uc333uet.1 
ENSMUST00000287855.1 ENSMUSG00000128473 ENSMUST00000287855.1 ENSMUSG00000128473 (from geneSymbol) uc333ueu.1 uc333ueu.1 
ENSMUST00000287858.1 ENSMUSG00000128474 ENSMUST00000287858.1 ENSMUSG00000128474 (from geneSymbol) uc333uex.1 uc333uex.1 
ENSMUST00000287862.1 ENSMUSG00000128475 ENSMUST00000287862.1 ENSMUSG00000128475 (from geneSymbol) uc333ufb.1 uc333ufb.1 
ENSMUST00000287865.1 ENSMUSG00000128476 ENSMUST00000287865.1 ENSMUSG00000128476 (from geneSymbol) uc333ufe.1 uc333ufe.1 
ENSMUST00000287866.1 ENSMUSG00000128477 ENSMUST00000287866.1 ENSMUSG00000128477 (from geneSymbol) uc333uff.1 uc333uff.1 
ENSMUST00000287867.1 ENSMUSG00000128478 ENSMUST00000287867.1 ENSMUSG00000128478 (from geneSymbol) uc333ufg.1 uc333ufg.1 
ENSMUST00000287868.1 ENSMUSG00000128479 ENSMUST00000287868.1 ENSMUSG00000128479 (from geneSymbol) uc333ufh.1 uc333ufh.1 
ENSMUST00000287870.1 4930505G20Rik ENSMUST00000287870.1 4930505G20Rik (from geneSymbol) AK015702 uc333ufj.1 uc333ufj.1 
ENSMUST00000287871.1 Gm37839 ENSMUST00000287871.1 Gm37839 (from geneSymbol) uc333ufk.1 uc333ufk.1 
ENSMUST00000287877.1 ENSMUSG00000128480 ENSMUST00000287877.1 ENSMUSG00000128480 (from geneSymbol) uc333ufq.1 uc333ufq.1 
ENSMUST00000287878.1 ENSMUSG00000128481 ENSMUST00000287878.1 ENSMUSG00000128481 (from geneSymbol) uc333ufr.1 uc333ufr.1 
ENSMUST00000287880.1 ENSMUSG00000128482 ENSMUST00000287880.1 ENSMUSG00000128482 (from geneSymbol) uc333uft.1 uc333uft.1 
ENSMUST00000287882.1 ENSMUSG00000128483 ENSMUST00000287882.1 ENSMUSG00000128483 (from geneSymbol) uc333ufv.1 uc333ufv.1 
ENSMUST00000287883.1 ENSMUSG00000128484 ENSMUST00000287883.1 ENSMUSG00000128484 (from geneSymbol) uc333ufw.1 uc333ufw.1 
ENSMUST00000287885.1 Gm21242 ENSMUST00000287885.1 Gm21242 (from geneSymbol) L04852 uc333ufy.1 uc333ufy.1 
ENSMUST00000287887.1 Gm27030 ENSMUST00000287887.1 Gm27030 (from geneSymbol) uc333uga.1 uc333uga.1 
ENSMUST00000287889.1 ENSMUSG00000128486 ENSMUST00000287889.1 ENSMUSG00000128486 (from geneSymbol) uc333ugc.1 uc333ugc.1 
ENSMUST00000287897.1 ENSMUSG00000128487 ENSMUST00000287897.1 ENSMUSG00000128487 (from geneSymbol) uc333ugk.1 uc333ugk.1 
ENSMUST00000287899.1 1700025D23Rik ENSMUST00000287899.1 1700025D23Rik (from geneSymbol) AK006331 uc333ugm.1 uc333ugm.1 
ENSMUST00000287903.1 ENSMUSG00000128488 ENSMUST00000287903.1 ENSMUSG00000128488 (from geneSymbol) uc333ugq.1 uc333ugq.1 
ENSMUST00000287904.1 ENSMUSG00000128489 ENSMUST00000287904.1 ENSMUSG00000128489 (from geneSymbol) uc333ugr.1 uc333ugr.1 
ENSMUST00000287905.1 ENSMUSG00000128490 ENSMUST00000287905.1 ENSMUSG00000128490 (from geneSymbol) AY139114 uc333ugs.1 uc333ugs.1 
ENSMUST00000287906.1 ENSMUSG00000128491 ENSMUST00000287906.1 ENSMUSG00000128491 (from geneSymbol) uc333ugt.1 uc333ugt.1 
ENSMUST00000287907.1 ENSMUSG00000128492 ENSMUST00000287907.1 ENSMUSG00000128492 (from geneSymbol) uc333ugu.1 uc333ugu.1 
ENSMUST00000287909.1 Gm11816 ENSMUST00000287909.1 Gm11816 (from geneSymbol) uc333ugw.1 uc333ugw.1 
ENSMUST00000287914.1 ENSMUSG00000128493 ENSMUST00000287914.1 ENSMUSG00000128493 (from geneSymbol) uc333uhb.1 uc333uhb.1 
ENSMUST00000287919.1 ENSMUSG00000128494 ENSMUST00000287919.1 ENSMUSG00000128494 (from geneSymbol) uc333uhg.1 uc333uhg.1 
ENSMUST00000287921.1 ENSMUSG00000128495 ENSMUST00000287921.1 ENSMUSG00000128495 (from geneSymbol) uc333uhi.1 uc333uhi.1 
ENSMUST00000287927.1 ENSMUSG00000128496 ENSMUST00000287927.1 ENSMUSG00000128496 (from geneSymbol) uc333uho.1 uc333uho.1 
ENSMUST00000287929.1 Gm36560 ENSMUST00000287929.1 Gm36560 (from geneSymbol) AK043982 uc333uhq.1 uc333uhq.1 
ENSMUST00000287948.1 ENSMUSG00000128497 ENSMUST00000287948.1 ENSMUSG00000128497 (from geneSymbol) uc333uij.1 uc333uij.1 
ENSMUST00000287950.1 ENSMUSG00000128498 ENSMUST00000287950.1 ENSMUSG00000128498 (from geneSymbol) uc333uil.1 uc333uil.1 
ENSMUST00000287952.1 ENSMUSG00000128499 ENSMUST00000287952.1 ENSMUSG00000128499 (from geneSymbol) uc333uin.1 uc333uin.1 
ENSMUST00000287954.1 ENSMUSG00000128500 ENSMUST00000287954.1 ENSMUSG00000128500 (from geneSymbol) uc333uip.1 uc333uip.1 
ENSMUST00000287959.1 ENSMUSG00000128502 ENSMUST00000287959.1 ENSMUSG00000128502 (from geneSymbol) AK133279 uc333uis.1 uc333uis.1 
ENSMUST00000287962.1 Maats1os ENSMUST00000287962.1 Maats1os (from geneSymbol) uc333uiv.1 uc333uiv.1 
ENSMUST00000287964.1 Gm56905 ENSMUST00000287964.1 Gm56905 (from geneSymbol) uc333uix.1 uc333uix.1 
ENSMUST00000287968.1 ENSMUSG00000128503 ENSMUST00000287968.1 ENSMUSG00000128503 (from geneSymbol) uc333ujb.1 uc333ujb.1 
ENSMUST00000287973.1 ENSMUSG00000128504 ENSMUST00000287973.1 ENSMUSG00000128504 (from geneSymbol) uc333ujg.1 uc333ujg.1 
ENSMUST00000287977.1 ENSMUSG00000128505 ENSMUST00000287977.1 ENSMUSG00000128505 (from geneSymbol) uc333ujk.1 uc333ujk.1 
ENSMUST00000287978.1 D430040D24Rik ENSMUST00000287978.1 D430040D24Rik (from geneSymbol) AK052542 uc333ujl.1 uc333ujl.1 
ENSMUST00000287979.1 ENSMUSG00000128506 ENSMUST00000287979.1 ENSMUSG00000128506 (from geneSymbol) uc333ujm.1 uc333ujm.1 
ENSMUST00000287980.1 ENSMUSG00000128507 ENSMUST00000287980.1 ENSMUSG00000128507 (from geneSymbol) uc333ujn.1 uc333ujn.1 
ENSMUST00000288001.1 ENSMUSG00000128508 ENSMUST00000288001.1 ENSMUSG00000128508 (from geneSymbol) uc333uki.1 uc333uki.1 
ENSMUST00000288010.1 ENSMUSG00000128509 ENSMUST00000288010.1 ENSMUSG00000128509 (from geneSymbol) LF197850 uc333ukr.1 uc333ukr.1 
ENSMUST00000288011.1 ENSMUSG00000128510 ENSMUST00000288011.1 ENSMUSG00000128510 (from geneSymbol) uc333uks.1 uc333uks.1 
ENSMUST00000288014.1 ENSMUSG00000128511 ENSMUST00000288014.1 ENSMUSG00000128511 (from geneSymbol) uc333ukv.1 uc333ukv.1 
ENSMUST00000288017.1 ENSMUSG00000128512 ENSMUST00000288017.1 ENSMUSG00000128512 (from geneSymbol) uc333uky.1 uc333uky.1 
ENSMUST00000288022.1 ENSMUSG00000128513 ENSMUST00000288022.1 ENSMUSG00000128513 (from geneSymbol) uc333uld.1 uc333uld.1 
ENSMUST00000288023.1 ENSMUSG00000128514 ENSMUST00000288023.1 ENSMUSG00000128514 (from geneSymbol) uc333ule.1 uc333ule.1 
ENSMUST00000288024.1 ENSMUSG00000128515 ENSMUST00000288024.1 ENSMUSG00000128515 (from geneSymbol) uc333ulf.1 uc333ulf.1 
ENSMUST00000288025.1 ENSMUSG00000128516 ENSMUST00000288025.1 ENSMUSG00000128516 (from geneSymbol) uc333ulg.1 uc333ulg.1 
ENSMUST00000288027.1 ENSMUSG00000128517 ENSMUST00000288027.1 ENSMUSG00000128517 (from geneSymbol) uc333uli.1 uc333uli.1 
ENSMUST00000288030.1 ENSMUSG00000128518 ENSMUST00000288030.1 ENSMUSG00000128518 (from geneSymbol) uc333ull.1 uc333ull.1 
ENSMUST00000288032.1 ENSMUSG00000128519 ENSMUST00000288032.1 ENSMUSG00000128519 (from geneSymbol) uc333ulm.1 uc333ulm.1 
ENSMUST00000288033.1 ENSMUSG00000128520 ENSMUST00000288033.1 ENSMUSG00000128520 (from geneSymbol) uc333uln.1 uc333uln.1 
ENSMUST00000288035.1 ENSMUSG00000128521 ENSMUST00000288035.1 ENSMUSG00000128521 (from geneSymbol) uc333ulp.1 uc333ulp.1 
ENSMUST00000288036.1 ENSMUSG00000128522 ENSMUST00000288036.1 ENSMUSG00000128522 (from geneSymbol) LF204667 uc333ulq.1 uc333ulq.1 
ENSMUST00000288037.1 ENSMUSG00000128523 ENSMUST00000288037.1 ENSMUSG00000128523 (from geneSymbol) uc333ulr.1 uc333ulr.1 
ENSMUST00000288040.1 ENSMUSG00000128524 ENSMUST00000288040.1 ENSMUSG00000128524 (from geneSymbol) uc333ulu.1 uc333ulu.1 
ENSMUST00000288042.1 ENSMUSG00000128525 ENSMUST00000288042.1 ENSMUSG00000128525 (from geneSymbol) uc333ulw.1 uc333ulw.1 
ENSMUST00000288043.1 ENSMUSG00000128526 ENSMUST00000288043.1 ENSMUSG00000128526 (from geneSymbol) uc333ulx.1 uc333ulx.1 
ENSMUST00000288045.1 Gm33228 ENSMUST00000288045.1 Gm33228 (from geneSymbol) uc333ulz.1 uc333ulz.1 
ENSMUST00000288178.1 ENSMUSG00000128527 ENSMUST00000288178.1 ENSMUSG00000128527 (from geneSymbol) uc333urc.1 uc333urc.1 
ENSMUST00000288179.1 ENSMUSG00000128528 ENSMUST00000288179.1 ENSMUSG00000128528 (from geneSymbol) uc333urd.1 uc333urd.1 
ENSMUST00000288183.1 ENSMUSG00000128529 ENSMUST00000288183.1 ENSMUSG00000128529 (from geneSymbol) uc333urh.1 uc333urh.1 
ENSMUST00000288184.1 ENSMUSG00000128530 ENSMUST00000288184.1 ENSMUSG00000128530 (from geneSymbol) uc333uri.1 uc333uri.1 
ENSMUST00000288187.1 ENSMUSG00000128531 ENSMUST00000288187.1 ENSMUSG00000128531 (from geneSymbol) uc333url.1 uc333url.1 
ENSMUST00000288192.1 ENSMUSG00000128532 ENSMUST00000288192.1 ENSMUSG00000128532 (from geneSymbol) uc333urq.1 uc333urq.1 
ENSMUST00000288212.1 ENSMUSG00000128533 ENSMUST00000288212.1 ENSMUSG00000128533 (from geneSymbol) uc333usj.1 uc333usj.1 
ENSMUST00000288213.1 ENSMUSG00000128534 ENSMUST00000288213.1 ENSMUSG00000128534 (from geneSymbol) uc333usk.1 uc333usk.1 
ENSMUST00000288218.1 ENSMUSG00000128535 ENSMUST00000288218.1 ENSMUSG00000128535 (from geneSymbol) uc333usp.1 uc333usp.1 
ENSMUST00000288228.1 4933422A05Rik ENSMUST00000288228.1 4933422A05Rik (from geneSymbol) AK016867 uc333usz.1 uc333usz.1 
ENSMUST00000288256.1 ENSMUSG00000128536 ENSMUST00000288256.1 ENSMUSG00000128536 (from geneSymbol) uc333uub.1 uc333uub.1 
ENSMUST00000288260.1 ENSMUSG00000128537 ENSMUST00000288260.1 ENSMUSG00000128537 (from geneSymbol) uc333uuf.1 uc333uuf.1 
ENSMUST00000288280.1 ENSMUSG00000128538 ENSMUST00000288280.1 ENSMUSG00000128538 (from geneSymbol) uc333uuz.1 uc333uuz.1 
ENSMUST00000288282.1 ENSMUSG00000128539 ENSMUST00000288282.1 ENSMUSG00000128539 (from geneSymbol) uc333uvb.1 uc333uvb.1 
ENSMUST00000288283.1 ENSMUSG00000128540 ENSMUST00000288283.1 ENSMUSG00000128540 (from geneSymbol) uc333uvc.1 uc333uvc.1 
ENSMUST00000288284.1 ENSMUSG00000128541 ENSMUST00000288284.1 ENSMUSG00000128541 (from geneSymbol) uc333uvd.1 uc333uvd.1 
ENSMUST00000288286.1 ENSMUSG00000128542 ENSMUST00000288286.1 ENSMUSG00000128542 (from geneSymbol) uc333uvf.1 uc333uvf.1 
ENSMUST00000288287.1 ENSMUSG00000128543 ENSMUST00000288287.1 ENSMUSG00000128543 (from geneSymbol) uc333uvg.1 uc333uvg.1 
ENSMUST00000288290.1 ENSMUSG00000128544 ENSMUST00000288290.1 ENSMUSG00000128544 (from geneSymbol) uc333uvj.1 uc333uvj.1 
ENSMUST00000288293.1 ENSMUSG00000128545 ENSMUST00000288293.1 ENSMUSG00000128545 (from geneSymbol) uc333uvm.1 uc333uvm.1 
ENSMUST00000288296.1 ENSMUSG00000128546 ENSMUST00000288296.1 ENSMUSG00000128546 (from geneSymbol) AK019747 uc333uvp.1 uc333uvp.1 
ENSMUST00000288297.1 ENSMUSG00000128547 ENSMUST00000288297.1 ENSMUSG00000128547 (from geneSymbol) uc333uvq.1 uc333uvq.1 
ENSMUST00000288298.1 ENSMUSG00000128548 ENSMUST00000288298.1 ENSMUSG00000128548 (from geneSymbol) uc333uvr.1 uc333uvr.1 
ENSMUST00000288305.1 ENSMUSG00000128549 ENSMUST00000288305.1 ENSMUSG00000128549 (from geneSymbol) uc333uvy.1 uc333uvy.1 
ENSMUST00000288308.1 ENSMUSG00000128550 ENSMUST00000288308.1 ENSMUSG00000128550 (from geneSymbol) uc333uwb.1 uc333uwb.1 
ENSMUST00000288309.1 ENSMUSG00000128551 ENSMUST00000288309.1 ENSMUSG00000128551 (from geneSymbol) uc333uwc.1 uc333uwc.1 
ENSMUST00000288312.1 ENSMUSG00000128552 ENSMUST00000288312.1 ENSMUSG00000128552 (from geneSymbol) uc333uwf.1 uc333uwf.1 
ENSMUST00000288329.1 ENSMUSG00000128553 ENSMUST00000288329.1 ENSMUSG00000128553 (from geneSymbol) uc333uww.1 uc333uww.1 
ENSMUST00000288330.1 ENSMUSG00000128554 ENSMUST00000288330.1 ENSMUSG00000128554 (from geneSymbol) uc333uwx.1 uc333uwx.1 
ENSMUST00000288331.1 Gm44796 ENSMUST00000288331.1 Gm44796 (from geneSymbol) uc333uwy.1 uc333uwy.1 
ENSMUST00000288332.1 ENSMUSG00000128555 ENSMUST00000288332.1 ENSMUSG00000128555 (from geneSymbol) uc333uwz.1 uc333uwz.1 
ENSMUST00000288343.1 ENSMUSG00000128556 ENSMUST00000288343.1 ENSMUSG00000128556 (from geneSymbol) uc333uxk.1 uc333uxk.1 
ENSMUST00000288345.1 Gm14022 ENSMUST00000288345.1 Gm14022 (from geneSymbol) AK141583 uc333uxm.1 uc333uxm.1 
ENSMUST00000288347.1 ENSMUSG00000128557 ENSMUST00000288347.1 ENSMUSG00000128557 (from geneSymbol) uc333uxo.1 uc333uxo.1 
ENSMUST00000288350.1 ENSMUSG00000128558 ENSMUST00000288350.1 ENSMUSG00000128558 (from geneSymbol) uc333uxr.1 uc333uxr.1 
ENSMUST00000288355.1 ENSMUSG00000128559 ENSMUST00000288355.1 ENSMUSG00000128559 (from geneSymbol) uc333uxw.1 uc333uxw.1 
ENSMUST00000288356.1 ENSMUSG00000128560 ENSMUST00000288356.1 ENSMUSG00000128560 (from geneSymbol) AK136091 uc333uxx.1 uc333uxx.1 
ENSMUST00000288358.1 ENSMUSG00000128561 ENSMUST00000288358.1 ENSMUSG00000128561 (from geneSymbol) uc333uxz.1 uc333uxz.1 
ENSMUST00000288359.1 ENSMUSG00000128562 ENSMUST00000288359.1 ENSMUSG00000128562 (from geneSymbol) uc333uya.1 uc333uya.1 
ENSMUST00000288360.1 Gm830 ENSMUST00000288360.1 Gm830 (from geneSymbol) AK157456 uc333uyb.1 uc333uyb.1 
ENSMUST00000288365.1 ENSMUSG00000128563 ENSMUST00000288365.1 ENSMUSG00000128563 (from geneSymbol) uc333uyg.1 uc333uyg.1 
ENSMUST00000288368.1 ENSMUSG00000128564 ENSMUST00000288368.1 ENSMUSG00000128564 (from geneSymbol) uc333uyj.1 uc333uyj.1 
ENSMUST00000288370.1 ENSMUSG00000128565 ENSMUST00000288370.1 ENSMUSG00000128565 (from geneSymbol) uc333uyl.1 uc333uyl.1 
ENSMUST00000288372.1 ENSMUSG00000128566 ENSMUST00000288372.1 ENSMUSG00000128566 (from geneSymbol) uc333uyn.1 uc333uyn.1 
ENSMUST00000288373.1 ENSMUSG00000128567 ENSMUST00000288373.1 ENSMUSG00000128567 (from geneSymbol) uc333uyo.1 uc333uyo.1 
ENSMUST00000288393.1 ENSMUSG00000128568 ENSMUST00000288393.1 ENSMUSG00000128568 (from geneSymbol) uc333uzi.1 uc333uzi.1 
ENSMUST00000288396.1 Gm56495 ENSMUST00000288396.1 Gm56495 (from geneSymbol) uc333uzl.1 uc333uzl.1 
ENSMUST00000288407.1 ENSMUSG00000128569 ENSMUST00000288407.1 ENSMUSG00000128569 (from geneSymbol) uc333uzw.1 uc333uzw.1 
ENSMUST00000288409.1 ENSMUSG00000128570 ENSMUST00000288409.1 ENSMUSG00000128570 (from geneSymbol) uc333uzy.1 uc333uzy.1 
ENSMUST00000288413.1 ENSMUSG00000128571 ENSMUST00000288413.1 ENSMUSG00000128571 (from geneSymbol) uc333vac.1 uc333vac.1 
ENSMUST00000288416.1 ENSMUSG00000128572 ENSMUST00000288416.1 ENSMUSG00000128572 (from geneSymbol) uc333vaf.1 uc333vaf.1 
ENSMUST00000288417.1 ENSMUSG00000128573 ENSMUST00000288417.1 ENSMUSG00000128573 (from geneSymbol) uc333vag.1 uc333vag.1 
ENSMUST00000288418.1 ENSMUSG00000128574 ENSMUST00000288418.1 ENSMUSG00000128574 (from geneSymbol) uc333vah.1 uc333vah.1 
ENSMUST00000288419.1 Gm4065 ENSMUST00000288419.1 Gm4065 (from geneSymbol) uc333vai.1 uc333vai.1 
ENSMUST00000288421.1 ENSMUSG00000128575 ENSMUST00000288421.1 ENSMUSG00000128575 (from geneSymbol) uc333vak.1 uc333vak.1 
ENSMUST00000288422.1 ENSMUSG00000128576 ENSMUST00000288422.1 ENSMUSG00000128576 (from geneSymbol) uc333val.1 uc333val.1 
ENSMUST00000288423.1 ENSMUSG00000128577 ENSMUST00000288423.1 ENSMUSG00000128577 (from geneSymbol) uc333vam.1 uc333vam.1 
ENSMUST00000288424.1 ENSMUSG00000128578 ENSMUST00000288424.1 ENSMUSG00000128578 (from geneSymbol) uc333van.1 uc333van.1 
ENSMUST00000288425.1 ENSMUSG00000128579 ENSMUST00000288425.1 ENSMUSG00000128579 (from geneSymbol) uc333vao.1 uc333vao.1 
ENSMUST00000288426.1 ENSMUSG00000128580 ENSMUST00000288426.1 ENSMUSG00000128580 (from geneSymbol) LF201483 uc333vap.1 uc333vap.1 
ENSMUST00000288428.1 ENSMUSG00000128581 ENSMUST00000288428.1 ENSMUSG00000128581 (from geneSymbol) uc333vaq.1 uc333vaq.1 
ENSMUST00000288429.1 ENSMUSG00000128582 ENSMUST00000288429.1 ENSMUSG00000128582 (from geneSymbol) uc333var.1 uc333var.1 
ENSMUST00000288431.1 Gm47800 ENSMUST00000288431.1 Gm47800 (from geneSymbol) uc333vat.1 uc333vat.1 
ENSMUST00000288436.1 ENSMUSG00000128583 ENSMUST00000288436.1 ENSMUSG00000128583 (from geneSymbol) uc333vay.1 uc333vay.1 
ENSMUST00000288437.1 ENSMUSG00000128584 ENSMUST00000288437.1 ENSMUSG00000128584 (from geneSymbol) uc333vaz.1 uc333vaz.1 
ENSMUST00000288443.1 ENSMUSG00000128585 ENSMUST00000288443.1 ENSMUSG00000128585 (from geneSymbol) uc333vbf.1 uc333vbf.1 
ENSMUST00000288444.1 ENSMUSG00000128586 ENSMUST00000288444.1 ENSMUSG00000128586 (from geneSymbol) uc333vbg.1 uc333vbg.1 
ENSMUST00000288445.1 ENSMUSG00000128587 ENSMUST00000288445.1 ENSMUSG00000128587 (from geneSymbol) uc333vbh.1 uc333vbh.1 
ENSMUST00000288446.1 ENSMUSG00000128588 ENSMUST00000288446.1 ENSMUSG00000128588 (from geneSymbol) uc333vbi.1 uc333vbi.1 
ENSMUST00000288447.1 ENSMUSG00000128589 ENSMUST00000288447.1 ENSMUSG00000128589 (from geneSymbol) uc333vbj.1 uc333vbj.1 
ENSMUST00000288449.1 ENSMUSG00000128590 ENSMUST00000288449.1 ENSMUSG00000128590 (from geneSymbol) uc333vbl.1 uc333vbl.1 
ENSMUST00000288450.1 Gm31415 ENSMUST00000288450.1 Gm31415 (from geneSymbol) uc333vbm.1 uc333vbm.1 
ENSMUST00000288464.1 ENSMUSG00000128591 ENSMUST00000288464.1 ENSMUSG00000128591 (from geneSymbol) uc333vca.1 uc333vca.1 
ENSMUST00000288472.1 ENSMUSG00000128592 ENSMUST00000288472.1 ENSMUSG00000128592 (from geneSymbol) uc333vci.1 uc333vci.1 
ENSMUST00000288474.1 Sgms1os1 ENSMUST00000288474.1 Sgms1os1 (from geneSymbol) AK035700 uc333vck.1 uc333vck.1 
ENSMUST00000288487.1 ENSMUSG00000128593 ENSMUST00000288487.1 ENSMUSG00000128593 (from geneSymbol) uc333vcx.1 uc333vcx.1 
ENSMUST00000288491.1 Gm57195 ENSMUST00000288491.1 Gm57195 (from geneSymbol) uc333vdb.1 uc333vdb.1 
ENSMUST00000288539.1 ENSMUSG00000128594 ENSMUST00000288539.1 ENSMUSG00000128594 (from geneSymbol) uc333vex.1 uc333vex.1 
ENSMUST00000288540.1 ENSMUSG00000128595 ENSMUST00000288540.1 ENSMUSG00000128595 (from geneSymbol) uc333vey.1 uc333vey.1 
ENSMUST00000288547.1 ENSMUSG00000128597 ENSMUST00000288547.1 ENSMUSG00000128597 (from geneSymbol) uc333vfa.1 uc333vfa.1 
ENSMUST00000288553.1 ENSMUSG00000128598 ENSMUST00000288553.1 ENSMUSG00000128598 (from geneSymbol) FJ654127 uc333vfg.1 uc333vfg.1 
ENSMUST00000288554.1 ENSMUSG00000128599 ENSMUST00000288554.1 ENSMUSG00000128599 (from geneSymbol) uc333vfh.1 uc333vfh.1 
ENSMUST00000288555.1 ENSMUSG00000128600 ENSMUST00000288555.1 ENSMUSG00000128600 (from geneSymbol) uc333vfi.1 uc333vfi.1 
ENSMUST00000288556.1 ENSMUSG00000128601 ENSMUST00000288556.1 ENSMUSG00000128601 (from geneSymbol) uc333vfj.1 uc333vfj.1 
ENSMUST00000288557.1 ENSMUSG00000128602 ENSMUST00000288557.1 ENSMUSG00000128602 (from geneSymbol) uc333vfk.1 uc333vfk.1 
ENSMUST00000288558.1 Gm12707 ENSMUST00000288558.1 Gm12707 (from geneSymbol) uc333vfl.1 uc333vfl.1 
ENSMUST00000288561.1 Gm56962 ENSMUST00000288561.1 Gm56962 (from geneSymbol) uc333vfo.1 uc333vfo.1 
ENSMUST00000288562.1 ENSMUSG00000128603 ENSMUST00000288562.1 ENSMUSG00000128603 (from geneSymbol) uc333vfp.1 uc333vfp.1 
ENSMUST00000288563.1 ENSMUSG00000128604 ENSMUST00000288563.1 ENSMUSG00000128604 (from geneSymbol) uc333vfq.1 uc333vfq.1 
ENSMUST00000288568.1 ENSMUSG00000128606 ENSMUST00000288568.1 ENSMUSG00000128606 (from geneSymbol) uc333vfu.1 uc333vfu.1 
ENSMUST00000288578.1 ENSMUSG00000128607 ENSMUST00000288578.1 ENSMUSG00000128607 (from geneSymbol) uc333vge.1 uc333vge.1 
ENSMUST00000288584.1 ENSMUSG00000128608 ENSMUST00000288584.1 ENSMUSG00000128608 (from geneSymbol) uc333vgk.1 uc333vgk.1 
ENSMUST00000288585.1 ENSMUSG00000128609 ENSMUST00000288585.1 ENSMUSG00000128609 (from geneSymbol) uc333vgl.1 uc333vgl.1 
ENSMUST00000288588.1 ENSMUSG00000128610 ENSMUST00000288588.1 ENSMUSG00000128610 (from geneSymbol) uc333vgo.1 uc333vgo.1 
ENSMUST00000288590.1 Gm14206 ENSMUST00000288590.1 Gm14206 (from geneSymbol) uc333vgq.1 uc333vgq.1 
ENSMUST00000288592.1 ENSMUSG00000128611 ENSMUST00000288592.1 ENSMUSG00000128611 (from geneSymbol) uc333vgs.1 uc333vgs.1 
ENSMUST00000288611.1 ENSMUSG00000128612 ENSMUST00000288611.1 ENSMUSG00000128612 (from geneSymbol) uc333vhl.1 uc333vhl.1 
ENSMUST00000288618.1 Rsf1os2 ENSMUST00000288618.1 Rsf1os2 (from geneSymbol) AK037770 uc333vhs.1 uc333vhs.1 
ENSMUST00000288626.1 ENSMUSG00000128613 ENSMUST00000288626.1 ENSMUSG00000128613 (from geneSymbol) uc333via.1 uc333via.1 
ENSMUST00000288627.1 ENSMUSG00000128614 ENSMUST00000288627.1 ENSMUSG00000128614 (from geneSymbol) uc333vib.1 uc333vib.1 
ENSMUST00000288629.1 ENSMUSG00000128615 ENSMUST00000288629.1 ENSMUSG00000128615 (from geneSymbol) uc333vid.1 uc333vid.1 
ENSMUST00000288630.1 ENSMUSG00000128616 ENSMUST00000288630.1 ENSMUSG00000128616 (from geneSymbol) uc333vie.1 uc333vie.1 
ENSMUST00000288634.1 ENSMUSG00000128617 ENSMUST00000288634.1 ENSMUSG00000128617 (from geneSymbol) uc333vii.1 uc333vii.1 
ENSMUST00000288637.1 ENSMUSG00000128618 ENSMUST00000288637.1 ENSMUSG00000128618 (from geneSymbol) uc333vil.1 uc333vil.1 
ENSMUST00000288639.1 ENSMUSG00000128619 ENSMUST00000288639.1 ENSMUSG00000128619 (from geneSymbol) uc333vin.1 uc333vin.1 
ENSMUST00000288640.1 ENSMUSG00000128620 ENSMUST00000288640.1 ENSMUSG00000128620 (from geneSymbol) FJ541091 uc333vio.1 uc333vio.1 
ENSMUST00000288643.1 ENSMUSG00000128622 ENSMUST00000288643.1 ENSMUSG00000128622 (from geneSymbol) uc333viq.1 uc333viq.1 
ENSMUST00000288644.1 ENSMUSG00000128623 ENSMUST00000288644.1 ENSMUSG00000128623 (from geneSymbol) uc333vir.1 uc333vir.1 
ENSMUST00000288651.1 Gm16894 ENSMUST00000288651.1 Gm16894 (from geneSymbol) AK041998 uc333viy.1 uc333viy.1 
ENSMUST00000288661.1 ENSMUSG00000128624 ENSMUST00000288661.1 ENSMUSG00000128624 (from geneSymbol) uc333vji.1 uc333vji.1 
ENSMUST00000288670.1 ENSMUSG00000128625 ENSMUST00000288670.1 ENSMUSG00000128625 (from geneSymbol) uc333vjr.1 uc333vjr.1 
ENSMUST00000288671.1 ENSMUSG00000128626 ENSMUST00000288671.1 ENSMUSG00000128626 (from geneSymbol) uc333vjs.1 uc333vjs.1 
ENSMUST00000288673.1 ENSMUSG00000128627 ENSMUST00000288673.1 ENSMUSG00000128627 (from geneSymbol) uc333vju.1 uc333vju.1 
ENSMUST00000288674.1 ENSMUSG00000128628 ENSMUST00000288674.1 ENSMUSG00000128628 (from geneSymbol) uc333vjv.1 uc333vjv.1 
ENSMUST00000288680.1 ENSMUSG00000128629 ENSMUST00000288680.1 ENSMUSG00000128629 (from geneSymbol) uc333vkb.1 uc333vkb.1 
ENSMUST00000288681.1 ENSMUSG00000128630 ENSMUST00000288681.1 ENSMUSG00000128630 (from geneSymbol) uc333vkc.1 uc333vkc.1 
ENSMUST00000288682.1 ENSMUSG00000128631 ENSMUST00000288682.1 ENSMUSG00000128631 (from geneSymbol) uc333vkd.1 uc333vkd.1 
ENSMUST00000288685.1 ENSMUSG00000128632 ENSMUST00000288685.1 ENSMUSG00000128632 (from geneSymbol) uc333vkg.1 uc333vkg.1 
ENSMUST00000288887.1 Gm44744 ENSMUST00000288887.1 Gm44744 (from geneSymbol) uc333vru.1 uc333vru.1 
ENSMUST00000288892.1 ENSMUSG00000128633 ENSMUST00000288892.1 ENSMUSG00000128633 (from geneSymbol) uc333vrz.1 uc333vrz.1 
ENSMUST00000288893.1 ENSMUSG00000128634 ENSMUST00000288893.1 ENSMUSG00000128634 (from geneSymbol) uc333vsa.1 uc333vsa.1 
ENSMUST00000288904.1 ENSMUSG00000128635 ENSMUST00000288904.1 ENSMUSG00000128635 (from geneSymbol) uc333vsl.1 uc333vsl.1 
ENSMUST00000288906.1 ENSMUSG00000128636 ENSMUST00000288906.1 ENSMUSG00000128636 (from geneSymbol) uc333vsn.1 uc333vsn.1 
ENSMUST00000288907.1 ENSMUSG00000128637 ENSMUST00000288907.1 ENSMUSG00000128637 (from geneSymbol) uc333vso.1 uc333vso.1 
ENSMUST00000288909.1 ENSMUSG00000128638 ENSMUST00000288909.1 ENSMUSG00000128638 (from geneSymbol) uc333vsq.1 uc333vsq.1 
ENSMUST00000288915.1 ENSMUSG00000128639 ENSMUST00000288915.1 ENSMUSG00000128639 (from geneSymbol) uc333vsw.1 uc333vsw.1 
ENSMUST00000288918.1 ENSMUSG00000128640 ENSMUST00000288918.1 ENSMUSG00000128640 (from geneSymbol) uc333vsz.1 uc333vsz.1 
ENSMUST00000288920.1 ENSMUSG00000128641 ENSMUST00000288920.1 ENSMUSG00000128641 (from geneSymbol) uc333vtb.1 uc333vtb.1 
ENSMUST00000288921.1 ENSMUSG00000128642 ENSMUST00000288921.1 ENSMUSG00000128642 (from geneSymbol) uc333vtc.1 uc333vtc.1 
ENSMUST00000288924.1 ENSMUSG00000128643 ENSMUST00000288924.1 ENSMUSG00000128643 (from geneSymbol) uc333vtf.1 uc333vtf.1 
ENSMUST00000288928.1 ENSMUSG00000128645 ENSMUST00000288928.1 ENSMUSG00000128645 (from geneSymbol) uc333vti.1 uc333vti.1 
ENSMUST00000288930.1 ENSMUSG00000128646 ENSMUST00000288930.1 ENSMUSG00000128646 (from geneSymbol) uc333vtk.1 uc333vtk.1 
ENSMUST00000288936.1 ENSMUSG00000128647 ENSMUST00000288936.1 ENSMUSG00000128647 (from geneSymbol) LF199029 uc333vtq.1 uc333vtq.1 
ENSMUST00000288937.1 ENSMUSG00000128648 ENSMUST00000288937.1 ENSMUSG00000128648 (from geneSymbol) uc333vtr.1 uc333vtr.1 
ENSMUST00000288938.1 ENSMUSG00000128649 ENSMUST00000288938.1 ENSMUSG00000128649 (from geneSymbol) uc333vts.1 uc333vts.1 
ENSMUST00000288941.1 ENSMUSG00000128650 ENSMUST00000288941.1 ENSMUSG00000128650 (from geneSymbol) uc333vtv.1 uc333vtv.1 
ENSMUST00000288944.1 ENSMUSG00000128651 ENSMUST00000288944.1 ENSMUSG00000128651 (from geneSymbol) uc333vty.1 uc333vty.1 
ENSMUST00000288950.1 Gm12349 ENSMUST00000288950.1 Gm12349 (from geneSymbol) uc333vue.1 uc333vue.1 
ENSMUST00000288952.1 ENSMUSG00000128652 ENSMUST00000288952.1 ENSMUSG00000128652 (from geneSymbol) uc333vug.1 uc333vug.1 
ENSMUST00000288955.1 ENSMUSG00000128653 ENSMUST00000288955.1 ENSMUSG00000128653 (from geneSymbol) uc333vuj.1 uc333vuj.1 
ENSMUST00000288956.1 Gm40038 ENSMUST00000288956.1 Gm40038 (from geneSymbol) AK052977 uc333vuk.1 uc333vuk.1 
ENSMUST00000288965.1 Gm16220 ENSMUST00000288965.1 Gm16220 (from geneSymbol) uc333vut.1 uc333vut.1 
ENSMUST00000288974.1 ENSMUSG00000128654 ENSMUST00000288974.1 ENSMUSG00000128654 (from geneSymbol) uc333vvc.1 uc333vvc.1 
ENSMUST00000288975.1 ENSMUSG00000128655 ENSMUST00000288975.1 ENSMUSG00000128655 (from geneSymbol) uc333vvd.1 uc333vvd.1 
ENSMUST00000288976.1 ENSMUSG00000128656 ENSMUST00000288976.1 ENSMUSG00000128656 (from geneSymbol) uc333vve.1 uc333vve.1 
ENSMUST00000288987.1 ENSMUSG00000128657 ENSMUST00000288987.1 ENSMUSG00000128657 (from geneSymbol) uc333vvp.1 uc333vvp.1 
ENSMUST00000288988.1 ENSMUSG00000128658 ENSMUST00000288988.1 ENSMUSG00000128658 (from geneSymbol) uc333vvq.1 uc333vvq.1 
ENSMUST00000288990.1 ENSMUSG00000128659 ENSMUST00000288990.1 ENSMUSG00000128659 (from geneSymbol) uc333vvs.1 uc333vvs.1 
ENSMUST00000288991.1 ENSMUSG00000128660 ENSMUST00000288991.1 ENSMUSG00000128660 (from geneSymbol) uc333vvt.1 uc333vvt.1 
ENSMUST00000288999.1 Gm30539 ENSMUST00000288999.1 Gm30539 (from geneSymbol) AK087024 uc333vwb.1 uc333vwb.1 
ENSMUST00000289002.1 ENSMUSG00000128661 ENSMUST00000289002.1 ENSMUSG00000128661 (from geneSymbol) uc333vwe.1 uc333vwe.1 
ENSMUST00000289004.1 ENSMUSG00000128662 ENSMUST00000289004.1 ENSMUSG00000128662 (from geneSymbol) uc333vwg.1 uc333vwg.1 
ENSMUST00000289007.1 ENSMUSG00000128663 ENSMUST00000289007.1 ENSMUSG00000128663 (from geneSymbol) uc333vwj.1 uc333vwj.1 
ENSMUST00000289011.1 ENSMUSG00000128664 ENSMUST00000289011.1 ENSMUSG00000128664 (from geneSymbol) uc333vwn.1 uc333vwn.1 
ENSMUST00000289012.1 ENSMUSG00000128665 ENSMUST00000289012.1 ENSMUSG00000128665 (from geneSymbol) uc333vwo.1 uc333vwo.1 
ENSMUST00000289014.1 Gm12121 ENSMUST00000289014.1 Gm12121 (from geneSymbol) uc333vwq.1 uc333vwq.1 
ENSMUST00000289019.1 ENSMUSG00000128666 ENSMUST00000289019.1 ENSMUSG00000128666 (from geneSymbol) uc333vwv.1 uc333vwv.1 
ENSMUST00000289020.1 ENSMUSG00000128667 ENSMUST00000289020.1 ENSMUSG00000128667 (from geneSymbol) uc333vww.1 uc333vww.1 
ENSMUST00000289022.1 ENSMUSG00000128668 ENSMUST00000289022.1 ENSMUSG00000128668 (from geneSymbol) uc333vwy.1 uc333vwy.1 
ENSMUST00000289026.1 Gm56672 ENSMUST00000289026.1 Gm56672 (from geneSymbol) uc333vxc.1 uc333vxc.1 
ENSMUST00000289037.1 6330418K02Rik ENSMUST00000289037.1 6330418K02Rik (from geneSymbol) AK005306 uc333vxn.1 uc333vxn.1 
ENSMUST00000289043.1 Lef1os1 ENSMUST00000289043.1 Lef1os1 (from geneSymbol) uc333vxt.1 uc333vxt.1 
ENSMUST00000289045.1 ENSMUSG00000128669 ENSMUST00000289045.1 ENSMUSG00000128669 (from geneSymbol) uc333vxv.1 uc333vxv.1 
ENSMUST00000289047.1 ENSMUSG00000128670 ENSMUST00000289047.1 ENSMUSG00000128670 (from geneSymbol) AK015984 uc333vxx.1 uc333vxx.1 
ENSMUST00000289051.1 Gm5103 ENSMUST00000289051.1 Gm5103 (from geneSymbol) AK042136 uc333vyb.1 uc333vyb.1 
ENSMUST00000289061.1 ENSMUSG00000128671 ENSMUST00000289061.1 ENSMUSG00000128671 (from geneSymbol) uc333vyl.1 uc333vyl.1 
ENSMUST00000289074.1 Meg3 ENSMUST00000289074.1 Meg3 (from geneSymbol) MB417745 uc333vyy.1 uc333vyy.1 
ENSMUST00000289092.1 Gm44516 ENSMUST00000289092.1 Gm44516 (from geneSymbol) uc333vzq.1 uc333vzq.1 
ENSMUST00000289099.1 ENSMUSG00000128672 ENSMUST00000289099.1 ENSMUSG00000128672 (from geneSymbol) uc333vzx.1 uc333vzx.1 
ENSMUST00000289116.1 ENSMUSG00000128673 ENSMUST00000289116.1 ENSMUSG00000128673 (from geneSymbol) uc333wan.1 uc333wan.1 
ENSMUST00000289132.1 ENSMUSG00000128674 ENSMUST00000289132.1 ENSMUSG00000128674 (from geneSymbol) uc333wbd.1 uc333wbd.1 
ENSMUST00000289133.1 ENSMUSG00000128675 ENSMUST00000289133.1 ENSMUSG00000128675 (from geneSymbol) uc333wbe.1 uc333wbe.1 
ENSMUST00000289136.1 ENSMUSG00000128676 ENSMUST00000289136.1 ENSMUSG00000128676 (from geneSymbol) uc333wbh.1 uc333wbh.1 
ENSMUST00000289151.1 ENSMUSG00000128677 ENSMUST00000289151.1 ENSMUSG00000128677 (from geneSymbol) uc333wbw.1 uc333wbw.1 
ENSMUST00000289152.1 ENSMUSG00000128678 ENSMUST00000289152.1 ENSMUSG00000128678 (from geneSymbol) uc333wbx.1 uc333wbx.1 
ENSMUST00000289154.1 ENSMUSG00000128679 ENSMUST00000289154.1 ENSMUSG00000128679 (from geneSymbol) uc333wbz.1 uc333wbz.1 
ENSMUST00000289158.1 ENSMUSG00000128680 ENSMUST00000289158.1 ENSMUSG00000128680 (from geneSymbol) uc333wcd.1 uc333wcd.1 
ENSMUST00000289185.1 ENSMUSG00000128681 ENSMUST00000289185.1 ENSMUSG00000128681 (from geneSymbol) uc333wde.1 uc333wde.1 
ENSMUST00000289189.1 ENSMUSG00000128682 ENSMUST00000289189.1 ENSMUSG00000128682 (from geneSymbol) uc333wdi.1 uc333wdi.1 
ENSMUST00000289190.1 ENSMUSG00000128683 ENSMUST00000289190.1 ENSMUSG00000128683 (from geneSymbol) uc333wdj.1 uc333wdj.1 
ENSMUST00000289193.1 ENSMUSG00000128684 ENSMUST00000289193.1 ENSMUSG00000128684 (from geneSymbol) uc333wdm.1 uc333wdm.1 
ENSMUST00000289195.1 ENSMUSG00000128685 ENSMUST00000289195.1 ENSMUSG00000128685 (from geneSymbol) uc333wdo.1 uc333wdo.1 
ENSMUST00000289197.1 ENSMUSG00000128686 ENSMUST00000289197.1 ENSMUSG00000128686 (from geneSymbol) uc333wdq.1 uc333wdq.1 
ENSMUST00000289199.1 ENSMUSG00000128687 ENSMUST00000289199.1 ENSMUSG00000128687 (from geneSymbol) uc333wds.1 uc333wds.1 
ENSMUST00000289200.1 ENSMUSG00000128688 ENSMUST00000289200.1 ENSMUSG00000128688 (from geneSymbol) uc333wdt.1 uc333wdt.1 
ENSMUST00000289204.1 ENSMUSG00000128689 ENSMUST00000289204.1 ENSMUSG00000128689 (from geneSymbol) uc333wdx.1 uc333wdx.1 
ENSMUST00000289207.1 ENSMUSG00000128691 ENSMUST00000289207.1 ENSMUSG00000128691 (from geneSymbol) uc333wdz.1 uc333wdz.1 
ENSMUST00000289220.1 ENSMUSG00000128692 ENSMUST00000289220.1 ENSMUSG00000128692 (from geneSymbol) uc333wem.1 uc333wem.1 
ENSMUST00000289222.1 ENSMUSG00000128693 ENSMUST00000289222.1 ENSMUSG00000128693 (from geneSymbol) uc333weo.1 uc333weo.1 
ENSMUST00000289224.1 ENSMUSG00000128694 ENSMUST00000289224.1 ENSMUSG00000128694 (from geneSymbol) uc333weq.1 uc333weq.1 
ENSMUST00000289225.1 ENSMUSG00000128695 ENSMUST00000289225.1 ENSMUSG00000128695 (from geneSymbol) uc333wer.1 uc333wer.1 
ENSMUST00000289227.1 ENSMUSG00000128696 ENSMUST00000289227.1 ENSMUSG00000128696 (from geneSymbol) uc333wet.1 uc333wet.1 
ENSMUST00000289228.1 ENSMUSG00000128697 ENSMUST00000289228.1 ENSMUSG00000128697 (from geneSymbol) uc333weu.1 uc333weu.1 
ENSMUST00000289229.1 ENSMUSG00000128698 ENSMUST00000289229.1 ENSMUSG00000128698 (from geneSymbol) uc333wev.1 uc333wev.1 
ENSMUST00000289230.1 ENSMUSG00000128699 ENSMUST00000289230.1 ENSMUSG00000128699 (from geneSymbol) uc333wew.1 uc333wew.1 
ENSMUST00000289232.1 ENSMUSG00000128700 ENSMUST00000289232.1 ENSMUSG00000128700 (from geneSymbol) uc333wey.1 uc333wey.1 
ENSMUST00000289237.1 ENSMUSG00000128701 ENSMUST00000289237.1 ENSMUSG00000128701 (from geneSymbol) uc333wfd.1 uc333wfd.1 
ENSMUST00000289240.1 ENSMUSG00000128702 ENSMUST00000289240.1 ENSMUSG00000128702 (from geneSymbol) uc333wfg.1 uc333wfg.1 
ENSMUST00000289242.1 ENSMUSG00000128703 ENSMUST00000289242.1 ENSMUSG00000128703 (from geneSymbol) uc333wfi.1 uc333wfi.1 
ENSMUST00000289253.1 1700030L20Rik ENSMUST00000289253.1 1700030L20Rik (from geneSymbol) AK006559 uc333wft.1 uc333wft.1 
ENSMUST00000289292.1 ENSMUSG00000128704 ENSMUST00000289292.1 ENSMUSG00000128704 (from geneSymbol) uc333whg.1 uc333whg.1 
ENSMUST00000289293.1 ENSMUSG00000128705 ENSMUST00000289293.1 ENSMUSG00000128705 (from geneSymbol) uc333whh.1 uc333whh.1 
ENSMUST00000289295.1 ENSMUSG00000128706 ENSMUST00000289295.1 ENSMUSG00000128706 (from geneSymbol) uc333whj.1 uc333whj.1 
ENSMUST00000289301.1 ENSMUSG00000128708 ENSMUST00000289301.1 ENSMUSG00000128708 (from geneSymbol) uc333who.1 uc333who.1 
ENSMUST00000289302.1 ENSMUSG00000128709 ENSMUST00000289302.1 ENSMUSG00000128709 (from geneSymbol) uc333whp.1 uc333whp.1 
ENSMUST00000289303.1 ENSMUSG00000128710 ENSMUST00000289303.1 ENSMUSG00000128710 (from geneSymbol) uc333whq.1 uc333whq.1 
ENSMUST00000289304.1 ENSMUSG00000128711 ENSMUST00000289304.1 ENSMUSG00000128711 (from geneSymbol) uc333whr.1 uc333whr.1 
ENSMUST00000289307.1 ENSMUSG00000128712 ENSMUST00000289307.1 ENSMUSG00000128712 (from geneSymbol) uc333whu.1 uc333whu.1 
ENSMUST00000289310.1 Gm36065 ENSMUST00000289310.1 Gm36065 (from geneSymbol) uc333whx.1 uc333whx.1 
ENSMUST00000289314.1 ENSMUSG00000128713 ENSMUST00000289314.1 ENSMUSG00000128713 (from geneSymbol) uc333wib.1 uc333wib.1 
ENSMUST00000289315.1 ENSMUSG00000128714 ENSMUST00000289315.1 ENSMUSG00000128714 (from geneSymbol) uc333wic.1 uc333wic.1 
ENSMUST00000289316.1 ENSMUSG00000128715 ENSMUST00000289316.1 ENSMUSG00000128715 (from geneSymbol) uc333wid.1 uc333wid.1 
ENSMUST00000289317.1 ENSMUSG00000128716 ENSMUST00000289317.1 ENSMUSG00000128716 (from geneSymbol) uc333wie.1 uc333wie.1 
ENSMUST00000289325.1 4930453L07Rik ENSMUST00000289325.1 4930453L07Rik (from geneSymbol) AK015455 uc333wim.1 uc333wim.1 
ENSMUST00000289339.1 ENSMUSG00000128717 ENSMUST00000289339.1 ENSMUSG00000128717 (from geneSymbol) uc333wja.1 uc333wja.1 
ENSMUST00000289347.1 ENSMUSG00000128718 ENSMUST00000289347.1 ENSMUSG00000128718 (from geneSymbol) uc333wji.1 uc333wji.1 
ENSMUST00000289363.1 Gm41541 ENSMUST00000289363.1 Gm41541 (from geneSymbol) uc333wjx.1 uc333wjx.1 
ENSMUST00000289372.1 ENSMUSG00000128719 ENSMUST00000289372.1 ENSMUSG00000128719 (from geneSymbol) uc333wkg.1 uc333wkg.1 
ENSMUST00000289373.1 ENSMUSG00000128720 ENSMUST00000289373.1 ENSMUSG00000128720 (from geneSymbol) uc333wkh.1 uc333wkh.1 
ENSMUST00000289374.1 ENSMUSG00000128721 ENSMUST00000289374.1 ENSMUSG00000128721 (from geneSymbol) uc333wki.1 uc333wki.1 
ENSMUST00000289396.1 ENSMUSG00000128722 ENSMUST00000289396.1 ENSMUSG00000128722 (from geneSymbol) uc333wle.1 uc333wle.1 
ENSMUST00000289397.1 ENSMUSG00000128723 ENSMUST00000289397.1 ENSMUSG00000128723 (from geneSymbol) uc333wlf.1 uc333wlf.1 
ENSMUST00000289402.1 ENSMUSG00000128724 ENSMUST00000289402.1 ENSMUSG00000128724 (from geneSymbol) uc333wlk.1 uc333wlk.1 
ENSMUST00000289407.1 ENSMUSG00000128725 ENSMUST00000289407.1 ENSMUSG00000128725 (from geneSymbol) uc333wlp.1 uc333wlp.1 
ENSMUST00000289412.1 ENSMUSG00000128726 ENSMUST00000289412.1 ENSMUSG00000128726 (from geneSymbol) uc333wlu.1 uc333wlu.1 
ENSMUST00000289414.1 ENSMUSG00000128727 ENSMUST00000289414.1 ENSMUSG00000128727 (from geneSymbol) uc333wlw.1 uc333wlw.1 
ENSMUST00000289415.1 ENSMUSG00000128728 ENSMUST00000289415.1 ENSMUSG00000128728 (from geneSymbol) uc333wlx.1 uc333wlx.1 
ENSMUST00000289417.1 ENSMUSG00000128729 ENSMUST00000289417.1 ENSMUSG00000128729 (from geneSymbol) uc333wlz.1 uc333wlz.1 
ENSMUST00000289419.1 ENSMUSG00000128730 ENSMUST00000289419.1 ENSMUSG00000128730 (from geneSymbol) uc333wmb.1 uc333wmb.1 
ENSMUST00000289423.1 ENSMUSG00000128731 ENSMUST00000289423.1 ENSMUSG00000128731 (from geneSymbol) uc333wmf.1 uc333wmf.1 
ENSMUST00000289425.1 ENSMUSG00000128732 ENSMUST00000289425.1 ENSMUSG00000128732 (from geneSymbol) uc333wmh.1 uc333wmh.1 
ENSMUST00000289426.1 ENSMUSG00000128733 ENSMUST00000289426.1 ENSMUSG00000128733 (from geneSymbol) uc333wmi.1 uc333wmi.1 
ENSMUST00000289432.1 ENSMUSG00000128734 ENSMUST00000289432.1 ENSMUSG00000128734 (from geneSymbol) uc333wmo.1 uc333wmo.1 
ENSMUST00000289433.1 ENSMUSG00000128735 ENSMUST00000289433.1 ENSMUSG00000128735 (from geneSymbol) uc333wmp.1 uc333wmp.1 
ENSMUST00000289435.1 A230107N01Rik ENSMUST00000289435.1 A230107N01Rik (from geneSymbol) AK053270 uc333wmr.1 uc333wmr.1 
ENSMUST00000289441.1 ENSMUSG00000128736 ENSMUST00000289441.1 ENSMUSG00000128736 (from geneSymbol) uc333wmx.1 uc333wmx.1 
ENSMUST00000289443.1 ENSMUSG00000128737 ENSMUST00000289443.1 ENSMUSG00000128737 (from geneSymbol) uc333wmz.1 uc333wmz.1 
ENSMUST00000289446.1 ENSMUSG00000128738 ENSMUST00000289446.1 ENSMUSG00000128738 (from geneSymbol) uc333wnc.1 uc333wnc.1 
ENSMUST00000289451.1 ENSMUSG00000128739 ENSMUST00000289451.1 ENSMUSG00000128739 (from geneSymbol) uc333wnh.1 uc333wnh.1 
ENSMUST00000289452.1 ENSMUSG00000128740 ENSMUST00000289452.1 ENSMUSG00000128740 (from geneSymbol) uc333wni.1 uc333wni.1 
ENSMUST00000289453.1 ENSMUSG00000128741 ENSMUST00000289453.1 ENSMUSG00000128741 (from geneSymbol) uc333wnj.1 uc333wnj.1 
ENSMUST00000289455.1 ENSMUSG00000128742 ENSMUST00000289455.1 ENSMUSG00000128742 (from geneSymbol) uc333wnl.1 uc333wnl.1 
ENSMUST00000289462.1 ENSMUSG00000128743 ENSMUST00000289462.1 ENSMUSG00000128743 (from geneSymbol) uc333wns.1 uc333wns.1 
ENSMUST00000289467.1 4930413E15Rik ENSMUST00000289467.1 4930413E15Rik (from geneSymbol) AK015127 uc333wnx.1 uc333wnx.1 
ENSMUST00000289475.1 ENSMUSG00000128744 ENSMUST00000289475.1 ENSMUSG00000128744 (from geneSymbol) uc333wof.1 uc333wof.1 
ENSMUST00000289477.1 ENSMUSG00000128745 ENSMUST00000289477.1 ENSMUSG00000128745 (from geneSymbol) uc333woh.1 uc333woh.1 
ENSMUST00000289500.1 ENSMUSG00000128746 ENSMUST00000289500.1 ENSMUSG00000128746 (from geneSymbol) uc333wpe.1 uc333wpe.1 
ENSMUST00000289506.1 ENSMUSG00000128747 ENSMUST00000289506.1 ENSMUSG00000128747 (from geneSymbol) uc333wpk.1 uc333wpk.1 
ENSMUST00000289508.1 Gm34922 ENSMUST00000289508.1 Gm34922 (from geneSymbol) uc333wpm.1 uc333wpm.1 
ENSMUST00000289520.1 ENSMUSG00000128748 ENSMUST00000289520.1 ENSMUSG00000128748 (from geneSymbol) uc333wpy.1 uc333wpy.1 
ENSMUST00000289522.1 ENSMUSG00000128749 ENSMUST00000289522.1 ENSMUSG00000128749 (from geneSymbol) uc333wqa.1 uc333wqa.1 
ENSMUST00000289524.1 ENSMUSG00000128750 ENSMUST00000289524.1 ENSMUSG00000128750 (from geneSymbol) uc333wqc.1 uc333wqc.1 
ENSMUST00000289526.1 ENSMUSG00000128751 ENSMUST00000289526.1 ENSMUSG00000128751 (from geneSymbol) uc333wqe.1 uc333wqe.1 
ENSMUST00000289533.1 ENSMUSG00000128752 ENSMUST00000289533.1 ENSMUSG00000128752 (from geneSymbol) uc333wql.1 uc333wql.1 
ENSMUST00000289545.1 ENSMUSG00000128753 ENSMUST00000289545.1 ENSMUSG00000128753 (from geneSymbol) uc333wqx.1 uc333wqx.1 
ENSMUST00000289561.1 ENSMUSG00000128754 ENSMUST00000289561.1 ENSMUSG00000128754 (from geneSymbol) uc333wrn.1 uc333wrn.1 
ENSMUST00000289562.1 ENSMUSG00000128755 ENSMUST00000289562.1 ENSMUSG00000128755 (from geneSymbol) uc333wro.1 uc333wro.1 
ENSMUST00000289563.1 ENSMUSG00000128756 ENSMUST00000289563.1 ENSMUSG00000128756 (from geneSymbol) uc333wrp.1 uc333wrp.1 
ENSMUST00000289564.1 ENSMUSG00000128757 ENSMUST00000289564.1 ENSMUSG00000128757 (from geneSymbol) uc333wrq.1 uc333wrq.1 
ENSMUST00000289566.1 ENSMUSG00000128758 ENSMUST00000289566.1 ENSMUSG00000128758 (from geneSymbol) uc333wrs.1 uc333wrs.1 
ENSMUST00000289625.1 Gm49462 ENSMUST00000289625.1 Gm49462 (from geneSymbol) uc333wtz.1 uc333wtz.1 
ENSMUST00000289633.1 ENSMUSG00000128759 ENSMUST00000289633.1 ENSMUSG00000128759 (from geneSymbol) uc333wuh.1 uc333wuh.1 
ENSMUST00000289638.1 ENSMUSG00000128760 ENSMUST00000289638.1 ENSMUSG00000128760 (from geneSymbol) uc333wum.1 uc333wum.1 
ENSMUST00000289639.1 ENSMUSG00000128761 ENSMUST00000289639.1 ENSMUSG00000128761 (from geneSymbol) uc333wun.1 uc333wun.1 
ENSMUST00000289642.1 ENSMUSG00000128762 ENSMUST00000289642.1 ENSMUSG00000128762 (from geneSymbol) uc333wuq.1 uc333wuq.1 
ENSMUST00000289647.1 ENSMUSG00000128763 ENSMUST00000289647.1 ENSMUSG00000128763 (from geneSymbol) uc333wuv.1 uc333wuv.1 
ENSMUST00000289660.1 ENSMUSG00000128764 ENSMUST00000289660.1 ENSMUSG00000128764 (from geneSymbol) uc333wvi.1 uc333wvi.1 
ENSMUST00000289662.1 ENSMUSG00000128765 ENSMUST00000289662.1 ENSMUSG00000128765 (from geneSymbol) uc333wvk.1 uc333wvk.1 
ENSMUST00000289665.1 ENSMUSG00000128766 ENSMUST00000289665.1 ENSMUSG00000128766 (from geneSymbol) uc333wvn.1 uc333wvn.1 
ENSMUST00000289669.1 ENSMUSG00000128767 ENSMUST00000289669.1 ENSMUSG00000128767 (from geneSymbol) uc333wvr.1 uc333wvr.1 
ENSMUST00000289671.1 ENSMUSG00000128768 ENSMUST00000289671.1 ENSMUSG00000128768 (from geneSymbol) uc333wvt.1 uc333wvt.1 
ENSMUST00000289677.1 ENSMUSG00000128769 ENSMUST00000289677.1 ENSMUSG00000128769 (from geneSymbol) uc333wvz.1 uc333wvz.1 
ENSMUST00000289678.1 ENSMUSG00000128770 ENSMUST00000289678.1 ENSMUSG00000128770 (from geneSymbol) uc333wwa.1 uc333wwa.1 
ENSMUST00000289680.1 ENSMUSG00000128771 ENSMUST00000289680.1 ENSMUSG00000128771 (from geneSymbol) uc333wwc.1 uc333wwc.1 
ENSMUST00000289681.1 ENSMUSG00000128772 ENSMUST00000289681.1 ENSMUSG00000128772 (from geneSymbol) uc333wwd.1 uc333wwd.1 
ENSMUST00000289683.1 ENSMUSG00000128773 ENSMUST00000289683.1 ENSMUSG00000128773 (from geneSymbol) uc333wwf.1 uc333wwf.1 
ENSMUST00000289686.1 ENSMUSG00000128774 ENSMUST00000289686.1 ENSMUSG00000128774 (from geneSymbol) AK019581 uc333wwi.1 uc333wwi.1 
ENSMUST00000289768.1 ENSMUSG00000128775 ENSMUST00000289768.1 ENSMUSG00000128775 (from geneSymbol) uc333wzm.1 uc333wzm.1 
ENSMUST00000289769.1 ENSMUSG00000128776 ENSMUST00000289769.1 ENSMUSG00000128776 (from geneSymbol) uc333wzn.1 uc333wzn.1 
ENSMUST00000289771.1 ENSMUSG00000128777 ENSMUST00000289771.1 ENSMUSG00000128777 (from geneSymbol) uc333wzp.1 uc333wzp.1 
ENSMUST00000289789.1 ENSMUSG00000128778 ENSMUST00000289789.1 ENSMUSG00000128778 (from geneSymbol) uc333xah.1 uc333xah.1 
ENSMUST00000289790.1 ENSMUSG00000128779 ENSMUST00000289790.1 ENSMUSG00000128779 (from geneSymbol) uc333xai.1 uc333xai.1 
ENSMUST00000289792.1 Gm33819 ENSMUST00000289792.1 Gm33819 (from geneSymbol) uc333xak.1 uc333xak.1 
ENSMUST00000289795.1 ENSMUSG00000128780 ENSMUST00000289795.1 ENSMUSG00000128780 (from geneSymbol) uc333xan.1 uc333xan.1 
ENSMUST00000289798.1 ENSMUSG00000128781 ENSMUST00000289798.1 ENSMUSG00000128781 (from geneSymbol) uc333xaq.1 uc333xaq.1 
ENSMUST00000289802.1 ENSMUSG00000128783 ENSMUST00000289802.1 ENSMUSG00000128783 (from geneSymbol) uc333xat.1 uc333xat.1 
ENSMUST00000289807.1 ENSMUSG00000128785 ENSMUST00000289807.1 ENSMUSG00000128785 (from geneSymbol) uc333xax.1 uc333xax.1 
ENSMUST00000289809.1 ENSMUSG00000128786 ENSMUST00000289809.1 ENSMUSG00000128786 (from geneSymbol) uc333xaz.1 uc333xaz.1 
ENSMUST00000289811.1 ENSMUSG00000128787 ENSMUST00000289811.1 ENSMUSG00000128787 (from geneSymbol) uc333xbb.1 uc333xbb.1 
ENSMUST00000289814.1 ENSMUSG00000128788 ENSMUST00000289814.1 ENSMUSG00000128788 (from geneSymbol) uc333xbe.1 uc333xbe.1 
ENSMUST00000289817.1 ENSMUSG00000128789 ENSMUST00000289817.1 ENSMUSG00000128789 (from geneSymbol) uc333xbh.1 uc333xbh.1 
ENSMUST00000289820.1 Gm30262 ENSMUST00000289820.1 Gm30262 (from geneSymbol) uc333xbk.1 uc333xbk.1 
ENSMUST00000289918.1 ENSMUSG00000128790 ENSMUST00000289918.1 ENSMUSG00000128790 (from geneSymbol) uc333xfd.1 uc333xfd.1 
ENSMUST00000289919.1 Gm47957 ENSMUST00000289919.1 Gm47957 (from geneSymbol) uc333xfe.1 uc333xfe.1 
ENSMUST00000289920.1 ENSMUSG00000128791 ENSMUST00000289920.1 ENSMUSG00000128791 (from geneSymbol) uc333xff.1 uc333xff.1 
ENSMUST00000289923.1 ENSMUSG00000128792 ENSMUST00000289923.1 ENSMUSG00000128792 (from geneSymbol) uc333xfi.1 uc333xfi.1 
ENSMUST00000289924.1 Gm45469 ENSMUST00000289924.1 Gm45469 (from geneSymbol) uc333xfj.1 uc333xfj.1 
ENSMUST00000289934.1 ENSMUSG00000128794 ENSMUST00000289934.1 ENSMUSG00000128794 (from geneSymbol) uc333xfn.1 uc333xfn.1 
ENSMUST00000289935.1 ENSMUSG00000128795 ENSMUST00000289935.1 ENSMUSG00000128795 (from geneSymbol) DQ720141 uc333xfo.1 uc333xfo.1 
ENSMUST00000289936.1 ENSMUSG00000128796 ENSMUST00000289936.1 ENSMUSG00000128796 (from geneSymbol) uc333xfp.1 uc333xfp.1 
ENSMUST00000289937.1 ENSMUSG00000128797 ENSMUST00000289937.1 ENSMUSG00000128797 (from geneSymbol) uc333xfq.1 uc333xfq.1 
ENSMUST00000289938.1 Gm36831 ENSMUST00000289938.1 Gm36831 (from geneSymbol) AK029582 uc333xfr.1 uc333xfr.1 
ENSMUST00000289941.1 2410004I01Rik ENSMUST00000289941.1 2410004I01Rik (from geneSymbol) AK010390 uc333xfu.1 uc333xfu.1 
ENSMUST00000289957.1 ENSMUSG00000128798 ENSMUST00000289957.1 ENSMUSG00000128798 (from geneSymbol) uc333xgk.1 uc333xgk.1 
ENSMUST00000289959.1 ENSMUSG00000128799 ENSMUST00000289959.1 ENSMUSG00000128799 (from geneSymbol) uc333xgm.1 uc333xgm.1 
ENSMUST00000289960.1 ENSMUSG00000128800 ENSMUST00000289960.1 ENSMUSG00000128800 (from geneSymbol) uc333xgn.1 uc333xgn.1 
ENSMUST00000289970.1 ENSMUSG00000128801 ENSMUST00000289970.1 ENSMUSG00000128801 (from geneSymbol) uc333xgx.1 uc333xgx.1 
ENSMUST00000289971.1 ENSMUSG00000128802 ENSMUST00000289971.1 ENSMUSG00000128802 (from geneSymbol) uc333xgy.1 uc333xgy.1 
ENSMUST00000289974.1 ENSMUSG00000128803 ENSMUST00000289974.1 ENSMUSG00000128803 (from geneSymbol) uc333xhb.1 uc333xhb.1 
ENSMUST00000289976.1 ENSMUSG00000128804 ENSMUST00000289976.1 ENSMUSG00000128804 (from geneSymbol) uc333xhd.1 uc333xhd.1 
ENSMUST00000289977.1 ENSMUSG00000128805 ENSMUST00000289977.1 ENSMUSG00000128805 (from geneSymbol) uc333xhe.1 uc333xhe.1 
ENSMUST00000289978.1 ENSMUSG00000128806 ENSMUST00000289978.1 ENSMUSG00000128806 (from geneSymbol) uc333xhf.1 uc333xhf.1 
ENSMUST00000289979.1 ENSMUSG00000128807 ENSMUST00000289979.1 ENSMUSG00000128807 (from geneSymbol) uc333xhg.1 uc333xhg.1 
ENSMUST00000289982.1 ENSMUSG00000128808 ENSMUST00000289982.1 ENSMUSG00000128808 (from geneSymbol) uc333xhj.1 uc333xhj.1 
ENSMUST00000289987.1 ENSMUSG00000128809 ENSMUST00000289987.1 ENSMUSG00000128809 (from geneSymbol) uc333xho.1 uc333xho.1 
ENSMUST00000290023.1 ENSMUSG00000128810 ENSMUST00000290023.1 ENSMUSG00000128810 (from geneSymbol) uc333xiy.1 uc333xiy.1 
ENSMUST00000290024.1 ENSMUSG00000128811 ENSMUST00000290024.1 ENSMUSG00000128811 (from geneSymbol) uc333xiz.1 uc333xiz.1 
ENSMUST00000290025.1 ENSMUSG00000128812 ENSMUST00000290025.1 ENSMUSG00000128812 (from geneSymbol) uc333xja.1 uc333xja.1 
ENSMUST00000290033.1 ENSMUSG00000128813 ENSMUST00000290033.1 ENSMUSG00000128813 (from geneSymbol) uc333xji.1 uc333xji.1 
ENSMUST00000290037.1 ENSMUSG00000128814 ENSMUST00000290037.1 ENSMUSG00000128814 (from geneSymbol) uc333xjm.1 uc333xjm.1 
ENSMUST00000290040.1 ENSMUSG00000128815 ENSMUST00000290040.1 ENSMUSG00000128815 (from geneSymbol) uc333xjp.1 uc333xjp.1 
ENSMUST00000290045.1 ENSMUSG00000128816 ENSMUST00000290045.1 ENSMUSG00000128816 (from geneSymbol) uc333xju.1 uc333xju.1 
ENSMUST00000290047.1 ENSMUSG00000128817 ENSMUST00000290047.1 ENSMUSG00000128817 (from geneSymbol) uc333xjw.1 uc333xjw.1 
ENSMUST00000290049.1 Gm17163 ENSMUST00000290049.1 Gm17163 (from geneSymbol) uc333xjy.1 uc333xjy.1 
ENSMUST00000290050.1 Gm30984 ENSMUST00000290050.1 Gm30984 (from geneSymbol) uc333xjz.1 uc333xjz.1 
ENSMUST00000290078.1 ENSMUSG00000128818 ENSMUST00000290078.1 ENSMUSG00000128818 (from geneSymbol) uc333xlb.1 uc333xlb.1 
ENSMUST00000290079.1 ENSMUSG00000128819 ENSMUST00000290079.1 ENSMUSG00000128819 (from geneSymbol) uc333xlc.1 uc333xlc.1 
ENSMUST00000290080.1 ENSMUSG00000128820 ENSMUST00000290080.1 ENSMUSG00000128820 (from geneSymbol) uc333xld.1 uc333xld.1 
ENSMUST00000290097.1 ENSMUSG00000128822 ENSMUST00000290097.1 ENSMUSG00000128822 (from geneSymbol) uc333xlp.1 uc333xlp.1 
ENSMUST00000290099.1 ENSMUSG00000128823 ENSMUST00000290099.1 ENSMUSG00000128823 (from geneSymbol) uc333xlr.1 uc333xlr.1 
ENSMUST00000290100.1 ENSMUSG00000128824 ENSMUST00000290100.1 ENSMUSG00000128824 (from geneSymbol) uc333xls.1 uc333xls.1 
ENSMUST00000290101.1 ENSMUSG00000128825 ENSMUST00000290101.1 ENSMUSG00000128825 (from geneSymbol) uc333xlt.1 uc333xlt.1 
ENSMUST00000290102.1 Gm12292 ENSMUST00000290102.1 Gm12292 (from geneSymbol) AK036759 uc333xlu.1 uc333xlu.1 
ENSMUST00000290113.1 Gm42797 ENSMUST00000290113.1 Gm42797 (from geneSymbol) uc333xmf.1 uc333xmf.1 
ENSMUST00000290122.1 ENSMUSG00000128826 ENSMUST00000290122.1 ENSMUSG00000128826 (from geneSymbol) uc333xmo.1 uc333xmo.1 
ENSMUST00000290126.1 Dancr ENSMUST00000290126.1 Dancr (from geneSymbol) uc333xms.1 uc333xms.1 
ENSMUST00000290132.1 ENSMUSG00000128827 ENSMUST00000290132.1 ENSMUSG00000128827 (from geneSymbol) uc333xmy.1 uc333xmy.1 
ENSMUST00000290133.1 ENSMUSG00000128828 ENSMUST00000290133.1 ENSMUSG00000128828 (from geneSymbol) uc333xmz.1 uc333xmz.1 
ENSMUST00000290134.1 ENSMUSG00000128829 ENSMUST00000290134.1 ENSMUSG00000128829 (from geneSymbol) uc333xna.1 uc333xna.1 
ENSMUST00000290146.1 ENSMUSG00000128830 ENSMUST00000290146.1 ENSMUSG00000128830 (from geneSymbol) uc333xnm.1 uc333xnm.1 
ENSMUST00000290149.1 ENSMUSG00000128831 ENSMUST00000290149.1 ENSMUSG00000128831 (from geneSymbol) uc333xnp.1 uc333xnp.1 
ENSMUST00000290161.1 ENSMUSG00000128832 ENSMUST00000290161.1 ENSMUSG00000128832 (from geneSymbol) uc333xob.1 uc333xob.1 
ENSMUST00000290162.1 Gm56906 ENSMUST00000290162.1 Gm56906 (from geneSymbol) uc333xoc.1 uc333xoc.1 
ENSMUST00000290167.1 ENSMUSG00000128833 ENSMUST00000290167.1 ENSMUSG00000128833 (from geneSymbol) uc333xoh.1 uc333xoh.1 
ENSMUST00000290168.1 ENSMUSG00000128834 ENSMUST00000290168.1 ENSMUSG00000128834 (from geneSymbol) uc333xoi.1 uc333xoi.1 
ENSMUST00000290186.1 ENSMUSG00000128835 ENSMUST00000290186.1 ENSMUSG00000128835 (from geneSymbol) AK134493 uc333xpa.1 uc333xpa.1 
ENSMUST00000290188.1 ENSMUSG00000128836 ENSMUST00000290188.1 ENSMUSG00000128836 (from geneSymbol) uc333xpc.1 uc333xpc.1 
ENSMUST00000290190.1 ENSMUSG00000128837 ENSMUST00000290190.1 ENSMUSG00000128837 (from geneSymbol) uc333xpe.1 uc333xpe.1 
ENSMUST00000290203.1 Gm27198 ENSMUST00000290203.1 Gm27198 (from geneSymbol) AK133101 uc333xpr.1 uc333xpr.1 
ENSMUST00000290237.1 ENSMUSG00000128838 ENSMUST00000290237.1 ENSMUSG00000128838 (from geneSymbol) uc333xqz.1 uc333xqz.1 
ENSMUST00000290239.1 ENSMUSG00000128839 ENSMUST00000290239.1 ENSMUSG00000128839 (from geneSymbol) uc333xrb.1 uc333xrb.1 
ENSMUST00000290240.1 ENSMUSG00000128840 ENSMUST00000290240.1 ENSMUSG00000128840 (from geneSymbol) uc333xrc.1 uc333xrc.1 
ENSMUST00000290241.1 ENSMUSG00000128841 ENSMUST00000290241.1 ENSMUSG00000128841 (from geneSymbol) uc333xrd.1 uc333xrd.1 
ENSMUST00000290242.1 ENSMUSG00000128842 ENSMUST00000290242.1 ENSMUSG00000128842 (from geneSymbol) uc333xre.1 uc333xre.1 
ENSMUST00000290243.1 ENSMUSG00000128843 ENSMUST00000290243.1 ENSMUSG00000128843 (from geneSymbol) uc333xrf.1 uc333xrf.1 
ENSMUST00000290245.1 ENSMUSG00000128844 ENSMUST00000290245.1 ENSMUSG00000128844 (from geneSymbol) uc333xrh.1 uc333xrh.1 
ENSMUST00000290246.1 ENSMUSG00000128845 ENSMUST00000290246.1 ENSMUSG00000128845 (from geneSymbol) uc333xri.1 uc333xri.1 
ENSMUST00000290256.1 ENSMUSG00000128846 ENSMUST00000290256.1 ENSMUSG00000128846 (from geneSymbol) uc333xrs.1 uc333xrs.1 
ENSMUST00000290258.1 ENSMUSG00000128847 ENSMUST00000290258.1 ENSMUSG00000128847 (from geneSymbol) uc333xru.1 uc333xru.1 
ENSMUST00000290276.1 ENSMUSG00000128848 ENSMUST00000290276.1 ENSMUSG00000128848 (from geneSymbol) uc333xsm.1 uc333xsm.1 
ENSMUST00000290278.1 ENSMUSG00000128849 ENSMUST00000290278.1 ENSMUSG00000128849 (from geneSymbol) uc333xso.1 uc333xso.1 
ENSMUST00000290279.1 ENSMUSG00000128850 ENSMUST00000290279.1 ENSMUSG00000128850 (from geneSymbol) uc333xsp.1 uc333xsp.1 
ENSMUST00000290280.1 ENSMUSG00000128851 ENSMUST00000290280.1 ENSMUSG00000128851 (from geneSymbol) uc333xsq.1 uc333xsq.1 
ENSMUST00000290281.1 ENSMUSG00000128852 ENSMUST00000290281.1 ENSMUSG00000128852 (from geneSymbol) uc333xsr.1 uc333xsr.1 
ENSMUST00000290282.1 ENSMUSG00000128853 ENSMUST00000290282.1 ENSMUSG00000128853 (from geneSymbol) AK008937 uc333xss.1 uc333xss.1 
ENSMUST00000290283.1 ENSMUSG00000128854 ENSMUST00000290283.1 ENSMUSG00000128854 (from geneSymbol) uc333xst.1 uc333xst.1 
ENSMUST00000290290.1 ENSMUSG00000128855 ENSMUST00000290290.1 ENSMUSG00000128855 (from geneSymbol) uc333xta.1 uc333xta.1 
ENSMUST00000290291.1 ENSMUSG00000128856 ENSMUST00000290291.1 ENSMUSG00000128856 (from geneSymbol) BC099537 uc333xtb.1 uc333xtb.1 
ENSMUST00000290294.1 ENSMUSG00000128857 ENSMUST00000290294.1 ENSMUSG00000128857 (from geneSymbol) uc333xte.1 uc333xte.1 
ENSMUST00000290295.1 Gm36298 ENSMUST00000290295.1 Gm36298 (from geneSymbol) uc333xtf.1 uc333xtf.1 
ENSMUST00000290300.1 Gm34035 ENSMUST00000290300.1 Gm34035 (from geneSymbol) uc333xtk.1 uc333xtk.1 
ENSMUST00000290327.1 ENSMUSG00000128859 ENSMUST00000290327.1 ENSMUSG00000128859 (from geneSymbol) uc333xuk.1 uc333xuk.1 
ENSMUST00000290329.1 ENSMUSG00000128860 ENSMUST00000290329.1 ENSMUSG00000128860 (from geneSymbol) uc333xul.1 uc333xul.1 
ENSMUST00000290332.1 Gm16876 ENSMUST00000290332.1 Gm16876 (from geneSymbol) AK040110 uc333xuo.1 uc333xuo.1 
ENSMUST00000290338.1 ENSMUSG00000128861 ENSMUST00000290338.1 ENSMUSG00000128861 (from geneSymbol) uc333xuu.1 uc333xuu.1 
ENSMUST00000290339.1 ENSMUSG00000128862 ENSMUST00000290339.1 ENSMUSG00000128862 (from geneSymbol) uc333xuv.1 uc333xuv.1 
ENSMUST00000290341.1 ENSMUSG00000128863 ENSMUST00000290341.1 ENSMUSG00000128863 (from geneSymbol) uc333xux.1 uc333xux.1 
ENSMUST00000290353.1 ENSMUSG00000128865 ENSMUST00000290353.1 ENSMUSG00000128865 (from geneSymbol) uc333xvi.1 uc333xvi.1 
ENSMUST00000290355.1 ENSMUSG00000128866 ENSMUST00000290355.1 ENSMUSG00000128866 (from geneSymbol) uc333xvk.1 uc333xvk.1 
ENSMUST00000290356.1 ENSMUSG00000128867 ENSMUST00000290356.1 ENSMUSG00000128867 (from geneSymbol) uc333xvl.1 uc333xvl.1 
ENSMUST00000290357.1 ENSMUSG00000128868 ENSMUST00000290357.1 ENSMUSG00000128868 (from geneSymbol) uc333xvm.1 uc333xvm.1 
ENSMUST00000290361.1 ENSMUSG00000128869 ENSMUST00000290361.1 ENSMUSG00000128869 (from geneSymbol) uc333xvq.1 uc333xvq.1 
ENSMUST00000290362.1 ENSMUSG00000128870 ENSMUST00000290362.1 ENSMUSG00000128870 (from geneSymbol) uc333xvr.1 uc333xvr.1 
ENSMUST00000290365.1 BB557941 ENSMUST00000290365.1 BB557941 (from geneSymbol) AK163349 uc333xvu.1 uc333xvu.1 
ENSMUST00000290372.1 ENSMUSG00000128871 ENSMUST00000290372.1 ENSMUSG00000128871 (from geneSymbol) uc333xwb.1 uc333xwb.1 
ENSMUST00000290375.1 ENSMUSG00000128872 ENSMUST00000290375.1 ENSMUSG00000128872 (from geneSymbol) uc333xwe.1 uc333xwe.1 
ENSMUST00000290377.1 ENSMUSG00000128873 ENSMUST00000290377.1 ENSMUSG00000128873 (from geneSymbol) uc333xwg.1 uc333xwg.1 
ENSMUST00000290407.1 ENSMUSG00000128874 ENSMUST00000290407.1 ENSMUSG00000128874 (from geneSymbol) uc333xxj.1 uc333xxj.1 
ENSMUST00000290423.1 ENSMUSG00000128875 ENSMUST00000290423.1 ENSMUSG00000128875 (from geneSymbol) FJ654127 uc333xxz.1 uc333xxz.1 
ENSMUST00000290424.1 ENSMUSG00000128876 ENSMUST00000290424.1 ENSMUSG00000128876 (from geneSymbol) uc333xya.1 uc333xya.1 
ENSMUST00000290426.1 ENSMUSG00000128877 ENSMUST00000290426.1 ENSMUSG00000128877 (from geneSymbol) uc333xyc.1 uc333xyc.1 
ENSMUST00000290442.1 Gm14820 ENSMUST00000290442.1 Gm14820 (from geneSymbol) uc333xys.1 uc333xys.1 
ENSMUST00000290455.1 Gm56658 ENSMUST00000290455.1 Gm56658 (from geneSymbol) uc333xzf.1 uc333xzf.1 
ENSMUST00000290457.1 Gm41506 ENSMUST00000290457.1 Gm41506 (from geneSymbol) AK146407 uc333xzh.1 uc333xzh.1 
ENSMUST00000290462.1 ENSMUSG00000128878 ENSMUST00000290462.1 ENSMUSG00000128878 (from geneSymbol) AK044380 uc333xzm.1 uc333xzm.1 
ENSMUST00000290463.1 ENSMUSG00000128879 ENSMUST00000290463.1 ENSMUSG00000128879 (from geneSymbol) uc333xzn.1 uc333xzn.1 
ENSMUST00000290467.1 ENSMUSG00000128880 ENSMUST00000290467.1 ENSMUSG00000128880 (from geneSymbol) uc333xzr.1 uc333xzr.1 
ENSMUST00000290468.1 ENSMUSG00000128881 ENSMUST00000290468.1 ENSMUSG00000128881 (from geneSymbol) uc333xzs.1 uc333xzs.1 
ENSMUST00000290469.1 ENSMUSG00000128882 ENSMUST00000290469.1 ENSMUSG00000128882 (from geneSymbol) uc333xzt.1 uc333xzt.1 
ENSMUST00000290471.1 ENSMUSG00000128883 ENSMUST00000290471.1 ENSMUSG00000128883 (from geneSymbol) uc333xzv.1 uc333xzv.1 
ENSMUST00000290472.1 ENSMUSG00000128884 ENSMUST00000290472.1 ENSMUSG00000128884 (from geneSymbol) uc333xzw.1 uc333xzw.1 
ENSMUST00000290474.1 ENSMUSG00000128885 ENSMUST00000290474.1 ENSMUSG00000128885 (from geneSymbol) uc333xzy.1 uc333xzy.1 
ENSMUST00000290476.1 ENSMUSG00000128886 ENSMUST00000290476.1 ENSMUSG00000128886 (from geneSymbol) uc333xzz.1 uc333xzz.1 
ENSMUST00000290478.1 ENSMUSG00000128887 ENSMUST00000290478.1 ENSMUSG00000128887 (from geneSymbol) uc333yab.1 uc333yab.1 
ENSMUST00000290479.1 ENSMUSG00000128888 ENSMUST00000290479.1 ENSMUSG00000128888 (from geneSymbol) uc333yac.1 uc333yac.1 
ENSMUST00000290481.1 ENSMUSG00000128889 ENSMUST00000290481.1 ENSMUSG00000128889 (from geneSymbol) uc333yae.1 uc333yae.1 
ENSMUST00000290498.1 Gm671 ENSMUST00000290498.1 Gm671 (from geneSymbol) uc333yav.1 uc333yav.1 
ENSMUST00000290499.1 Gm39556 ENSMUST00000290499.1 Gm39556 (from geneSymbol) uc333yaw.1 uc333yaw.1 
ENSMUST00000290505.1 ENSMUSG00000128890 ENSMUST00000290505.1 ENSMUSG00000128890 (from geneSymbol) uc333ybc.1 uc333ybc.1 
ENSMUST00000290508.1 4930584F24Rik ENSMUST00000290508.1 4930584F24Rik (from geneSymbol) AK005600 uc333ybf.1 uc333ybf.1 
ENSMUST00000290625.1 ENSMUSG00000128891 ENSMUST00000290625.1 ENSMUSG00000128891 (from geneSymbol) uc333yfr.1 uc333yfr.1 
ENSMUST00000290628.1 ENSMUSG00000128892 ENSMUST00000290628.1 ENSMUSG00000128892 (from geneSymbol) uc333yfu.1 uc333yfu.1 
ENSMUST00000290629.1 ENSMUSG00000128893 ENSMUST00000290629.1 ENSMUSG00000128893 (from geneSymbol) uc333yfv.1 uc333yfv.1 
ENSMUST00000290635.1 ENSMUSG00000128894 ENSMUST00000290635.1 ENSMUSG00000128894 (from geneSymbol) uc333ygb.1 uc333ygb.1 
ENSMUST00000290636.1 ENSMUSG00000128895 ENSMUST00000290636.1 ENSMUSG00000128895 (from geneSymbol) uc333ygc.1 uc333ygc.1 
ENSMUST00000290638.1 ENSMUSG00000128896 ENSMUST00000290638.1 ENSMUSG00000128896 (from geneSymbol) uc333yge.1 uc333yge.1 
ENSMUST00000290640.1 ENSMUSG00000128897 ENSMUST00000290640.1 ENSMUSG00000128897 (from geneSymbol) uc333ygg.1 uc333ygg.1 
ENSMUST00000290641.1 ENSMUSG00000128898 ENSMUST00000290641.1 ENSMUSG00000128898 (from geneSymbol) uc333ygh.1 uc333ygh.1 
ENSMUST00000290644.1 ENSMUSG00000128899 ENSMUST00000290644.1 ENSMUSG00000128899 (from geneSymbol) uc333ygk.1 uc333ygk.1 
ENSMUST00000290648.1 ENSMUSG00000128900 ENSMUST00000290648.1 ENSMUSG00000128900 (from geneSymbol) uc333ygo.1 uc333ygo.1 
ENSMUST00000290649.1 ENSMUSG00000128901 ENSMUST00000290649.1 ENSMUSG00000128901 (from geneSymbol) uc333ygp.1 uc333ygp.1 
ENSMUST00000290650.1 ENSMUSG00000128902 ENSMUST00000290650.1 ENSMUSG00000128902 (from geneSymbol) uc333ygq.1 uc333ygq.1 
ENSMUST00000290651.1 ENSMUSG00000128903 ENSMUST00000290651.1 ENSMUSG00000128903 (from geneSymbol) uc333ygr.1 uc333ygr.1 
ENSMUST00000290652.1 ENSMUSG00000128904 ENSMUST00000290652.1 ENSMUSG00000128904 (from geneSymbol) uc333ygs.1 uc333ygs.1 
ENSMUST00000290653.1 ENSMUSG00000128905 ENSMUST00000290653.1 ENSMUSG00000128905 (from geneSymbol) uc333ygt.1 uc333ygt.1 
ENSMUST00000290654.1 ENSMUSG00000128906 ENSMUST00000290654.1 ENSMUSG00000128906 (from geneSymbol) uc333ygu.1 uc333ygu.1 
ENSMUST00000290660.1 ENSMUSG00000128907 ENSMUST00000290660.1 ENSMUSG00000128907 (from geneSymbol) uc333yha.1 uc333yha.1 
ENSMUST00000290661.1 ENSMUSG00000128908 ENSMUST00000290661.1 ENSMUSG00000128908 (from geneSymbol) uc333yhb.1 uc333yhb.1 
ENSMUST00000290666.1 ENSMUSG00000128909 ENSMUST00000290666.1 ENSMUSG00000128909 (from geneSymbol) uc333yhg.1 uc333yhg.1 
ENSMUST00000290669.1 ENSMUSG00000128910 ENSMUST00000290669.1 ENSMUSG00000128910 (from geneSymbol) uc333yhj.1 uc333yhj.1 
ENSMUST00000290670.1 ENSMUSG00000128911 ENSMUST00000290670.1 ENSMUSG00000128911 (from geneSymbol) uc333yhk.1 uc333yhk.1 
ENSMUST00000290672.1 ENSMUSG00000128912 ENSMUST00000290672.1 ENSMUSG00000128912 (from geneSymbol) uc333yhm.1 uc333yhm.1 
ENSMUST00000290673.1 ENSMUSG00000128913 ENSMUST00000290673.1 ENSMUSG00000128913 (from geneSymbol) DQ697507 uc333yhn.1 uc333yhn.1 
ENSMUST00000290674.1 4930555B11Rik ENSMUST00000290674.1 4930555B11Rik (from geneSymbol) AK016127 uc333yho.1 uc333yho.1 
ENSMUST00000290676.1 ENSMUSG00000128914 ENSMUST00000290676.1 ENSMUSG00000128914 (from geneSymbol) uc333yhq.1 uc333yhq.1 
ENSMUST00000290681.1 ENSMUSG00000128916 ENSMUST00000290681.1 ENSMUSG00000128916 (from geneSymbol) uc333yhu.1 uc333yhu.1 
ENSMUST00000290682.1 ENSMUSG00000128917 ENSMUST00000290682.1 ENSMUSG00000128917 (from geneSymbol) AK144893 uc333yhv.1 uc333yhv.1 
ENSMUST00000290684.1 ENSMUSG00000128918 ENSMUST00000290684.1 ENSMUSG00000128918 (from geneSymbol) uc333yhx.1 uc333yhx.1 
ENSMUST00000290688.1 ENSMUSG00000128919 ENSMUST00000290688.1 ENSMUSG00000128919 (from geneSymbol) uc333yib.1 uc333yib.1 
ENSMUST00000290689.1 ENSMUSG00000128920 ENSMUST00000290689.1 ENSMUSG00000128920 (from geneSymbol) uc333yic.1 uc333yic.1 
ENSMUST00000290690.1 ENSMUSG00000128921 ENSMUST00000290690.1 ENSMUSG00000128921 (from geneSymbol) uc333yid.1 uc333yid.1 
ENSMUST00000290691.1 ENSMUSG00000128922 ENSMUST00000290691.1 ENSMUSG00000128922 (from geneSymbol) uc333yie.1 uc333yie.1 
ENSMUST00000290692.1 ENSMUSG00000128923 ENSMUST00000290692.1 ENSMUSG00000128923 (from geneSymbol) uc333yif.1 uc333yif.1 
ENSMUST00000290697.1 ENSMUSG00000128924 ENSMUST00000290697.1 ENSMUSG00000128924 (from geneSymbol) uc333yik.1 uc333yik.1 
ENSMUST00000290698.1 ENSMUSG00000128925 ENSMUST00000290698.1 ENSMUSG00000128925 (from geneSymbol) uc333yil.1 uc333yil.1 
ENSMUST00000290699.1 ENSMUSG00000128926 ENSMUST00000290699.1 ENSMUSG00000128926 (from geneSymbol) uc333yim.1 uc333yim.1 
ENSMUST00000290701.1 ENSMUSG00000128928 ENSMUST00000290701.1 ENSMUSG00000128928 (from geneSymbol) uc333yin.1 uc333yin.1 
ENSMUST00000290702.1 ENSMUSG00000128929 ENSMUST00000290702.1 ENSMUSG00000128929 (from geneSymbol) uc333yio.1 uc333yio.1 
ENSMUST00000290703.1 Gm26871 ENSMUST00000290703.1 Gm26871 (from geneSymbol) AK076759 uc333yip.1 uc333yip.1 
ENSMUST00000290729.1 Gm6416 ENSMUST00000290729.1 Gm6416 (from geneSymbol) AK041110 uc333yjp.1 uc333yjp.1 
ENSMUST00000290738.1 Gm31621 ENSMUST00000290738.1 Gm31621 (from geneSymbol) uc333yjy.1 uc333yjy.1 
ENSMUST00000290741.1 ENSMUSG00000128930 ENSMUST00000290741.1 ENSMUSG00000128930 (from geneSymbol) uc333ykb.1 uc333ykb.1 
ENSMUST00000290744.1 ENSMUSG00000128931 ENSMUST00000290744.1 ENSMUSG00000128931 (from geneSymbol) uc333yke.1 uc333yke.1 
ENSMUST00000290748.1 ENSMUSG00000128932 ENSMUST00000290748.1 ENSMUSG00000128932 (from geneSymbol) uc333yki.1 uc333yki.1 
ENSMUST00000290751.1 ENSMUSG00000128933 ENSMUST00000290751.1 ENSMUSG00000128933 (from geneSymbol) uc333ykl.1 uc333ykl.1 
ENSMUST00000290754.1 Gm38901 ENSMUST00000290754.1 Gm38901 (from geneSymbol) AK039590 uc333yko.1 uc333yko.1 
ENSMUST00000290772.1 ENSMUSG00000128934 ENSMUST00000290772.1 ENSMUSG00000128934 (from geneSymbol) uc333ylg.1 uc333ylg.1 
ENSMUST00000290774.1 ENSMUSG00000128935 ENSMUST00000290774.1 ENSMUSG00000128935 (from geneSymbol) uc333yli.1 uc333yli.1 
ENSMUST00000290783.1 ENSMUSG00000128936 ENSMUST00000290783.1 ENSMUSG00000128936 (from geneSymbol) LF275097 uc333ylr.1 uc333ylr.1 
ENSMUST00000290784.1 ENSMUSG00000128937 ENSMUST00000290784.1 ENSMUSG00000128937 (from geneSymbol) uc333yls.1 uc333yls.1 
ENSMUST00000290785.1 ENSMUSG00000128938 ENSMUST00000290785.1 ENSMUSG00000128938 (from geneSymbol) uc333ylt.1 uc333ylt.1 
ENSMUST00000290786.1 ENSMUSG00000128939 ENSMUST00000290786.1 ENSMUSG00000128939 (from geneSymbol) uc333ylu.1 uc333ylu.1 
ENSMUST00000290787.1 ENSMUSG00000128940 ENSMUST00000290787.1 ENSMUSG00000128940 (from geneSymbol) uc333ylv.1 uc333ylv.1 
ENSMUST00000290788.1 Gm12764 ENSMUST00000290788.1 Gm12764 (from geneSymbol) uc333ylw.1 uc333ylw.1 
ENSMUST00000290790.1 ENSMUSG00000128941 ENSMUST00000290790.1 ENSMUSG00000128941 (from geneSymbol) uc333yly.1 uc333yly.1 
ENSMUST00000290794.1 ENSMUSG00000128942 ENSMUST00000290794.1 ENSMUSG00000128942 (from geneSymbol) uc333ymc.1 uc333ymc.1 
ENSMUST00000290795.1 ENSMUSG00000128943 ENSMUST00000290795.1 ENSMUSG00000128943 (from geneSymbol) uc333ymd.1 uc333ymd.1 
ENSMUST00000290804.1 ENSMUSG00000128944 ENSMUST00000290804.1 ENSMUSG00000128944 (from geneSymbol) uc333ymm.1 uc333ymm.1 
ENSMUST00000290805.1 ENSMUSG00000128945 ENSMUST00000290805.1 ENSMUSG00000128945 (from geneSymbol) uc333ymn.1 uc333ymn.1 
ENSMUST00000290807.1 Gm52829 ENSMUST00000290807.1 Gm52829 (from geneSymbol) uc333ymp.1 uc333ymp.1 
ENSMUST00000290815.1 ENSMUSG00000128946 ENSMUST00000290815.1 ENSMUSG00000128946 (from geneSymbol) uc333ymx.1 uc333ymx.1 
ENSMUST00000290817.1 ENSMUSG00000128947 ENSMUST00000290817.1 ENSMUSG00000128947 (from geneSymbol) uc333ymz.1 uc333ymz.1 
ENSMUST00000290824.1 Gm45822 ENSMUST00000290824.1 Gm45822 (from geneSymbol) uc333yng.1 uc333yng.1 
ENSMUST00000290833.1 ENSMUSG00000128948 ENSMUST00000290833.1 ENSMUSG00000128948 (from geneSymbol) uc333ynp.1 uc333ynp.1 
ENSMUST00000290835.1 ENSMUSG00000128949 ENSMUST00000290835.1 ENSMUSG00000128949 (from geneSymbol) uc333ynr.1 uc333ynr.1 
ENSMUST00000290836.1 ENSMUSG00000128950 ENSMUST00000290836.1 ENSMUSG00000128950 (from geneSymbol) uc333yns.1 uc333yns.1 
ENSMUST00000290840.1 Gm32877 ENSMUST00000290840.1 Gm32877 (from geneSymbol) uc333ynw.1 uc333ynw.1 
ENSMUST00000290857.1 ENSMUSG00000128951 ENSMUST00000290857.1 ENSMUSG00000128951 (from geneSymbol) uc333yon.1 uc333yon.1 
ENSMUST00000290859.1 ENSMUSG00000128952 ENSMUST00000290859.1 ENSMUSG00000128952 (from geneSymbol) uc333yop.1 uc333yop.1 
ENSMUST00000290861.1 Gm49871 ENSMUST00000290861.1 Gm49871 (from geneSymbol) AK079730 uc333yor.1 uc333yor.1 
ENSMUST00000290865.1 Gm35550 ENSMUST00000290865.1 Gm35550 (from geneSymbol) uc333yov.1 uc333yov.1 
ENSMUST00000290879.1 ENSMUSG00000128953 ENSMUST00000290879.1 ENSMUSG00000128953 (from geneSymbol) uc333ypj.1 uc333ypj.1 
ENSMUST00000290886.1 ENSMUSG00000128954 ENSMUST00000290886.1 ENSMUSG00000128954 (from geneSymbol) uc333ypq.1 uc333ypq.1 
ENSMUST00000290907.1 ENSMUSG00000128955 ENSMUST00000290907.1 ENSMUSG00000128955 (from geneSymbol) uc333yql.1 uc333yql.1 
ENSMUST00000290909.1 ENSMUSG00000128956 ENSMUST00000290909.1 ENSMUSG00000128956 (from geneSymbol) uc333yqn.1 uc333yqn.1 
ENSMUST00000290910.1 ENSMUSG00000128957 ENSMUST00000290910.1 ENSMUSG00000128957 (from geneSymbol) uc333yqo.1 uc333yqo.1 
ENSMUST00000290912.1 ENSMUSG00000128958 ENSMUST00000290912.1 ENSMUSG00000128958 (from geneSymbol) uc333yqq.1 uc333yqq.1 
ENSMUST00000290913.1 ENSMUSG00000128959 ENSMUST00000290913.1 ENSMUSG00000128959 (from geneSymbol) uc333yqr.1 uc333yqr.1 
ENSMUST00000290914.1 Gm12510 ENSMUST00000290914.1 Gm12510 (from geneSymbol) uc333yqs.1 uc333yqs.1 
ENSMUST00000290919.1 ENSMUSG00000128960 ENSMUST00000290919.1 ENSMUSG00000128960 (from geneSymbol) uc333yqx.1 uc333yqx.1 
ENSMUST00000290922.1 ENSMUSG00000128961 ENSMUST00000290922.1 ENSMUSG00000128961 (from geneSymbol) uc333yra.1 uc333yra.1 
ENSMUST00000290923.1 ENSMUSG00000128962 ENSMUST00000290923.1 ENSMUSG00000128962 (from geneSymbol) uc333yrb.1 uc333yrb.1 
ENSMUST00000290936.1 ENSMUSG00000128963 ENSMUST00000290936.1 ENSMUSG00000128963 (from geneSymbol) uc333yro.1 uc333yro.1 
ENSMUST00000290940.1 4930403D09Rik ENSMUST00000290940.1 4930403D09Rik (from geneSymbol) AK076655 uc333yrs.1 uc333yrs.1 
ENSMUST00000290948.1 ENSMUSG00000128964 ENSMUST00000290948.1 ENSMUSG00000128964 (from geneSymbol) uc333ysa.1 uc333ysa.1 
ENSMUST00000290956.1 ENSMUSG00000128965 ENSMUST00000290956.1 ENSMUSG00000128965 (from geneSymbol) uc333ysi.1 uc333ysi.1 
ENSMUST00000290957.1 ENSMUSG00000128966 ENSMUST00000290957.1 ENSMUSG00000128966 (from geneSymbol) uc333ysj.1 uc333ysj.1 
ENSMUST00000290959.1 ENSMUSG00000128967 ENSMUST00000290959.1 ENSMUSG00000128967 (from geneSymbol) uc333ysl.1 uc333ysl.1 
ENSMUST00000290962.1 ENSMUSG00000128968 ENSMUST00000290962.1 ENSMUSG00000128968 (from geneSymbol) uc333yso.1 uc333yso.1 
ENSMUST00000290966.1 ENSMUSG00000128969 ENSMUST00000290966.1 ENSMUSG00000128969 (from geneSymbol) BC049716 uc333yss.1 uc333yss.1 
ENSMUST00000290968.1 ENSMUSG00000128970 ENSMUST00000290968.1 ENSMUSG00000128970 (from geneSymbol) uc333ysu.1 uc333ysu.1 
ENSMUST00000290970.1 ENSMUSG00000128971 ENSMUST00000290970.1 ENSMUSG00000128971 (from geneSymbol) uc333ysw.1 uc333ysw.1 
ENSMUST00000290973.1 ENSMUSG00000128972 ENSMUST00000290973.1 ENSMUSG00000128972 (from geneSymbol) uc333ysz.1 uc333ysz.1 
ENSMUST00000290976.1 ENSMUSG00000128973 ENSMUST00000290976.1 ENSMUSG00000128973 (from geneSymbol) uc333ytc.1 uc333ytc.1 
ENSMUST00000290982.1 ENSMUSG00000128974 ENSMUST00000290982.1 ENSMUSG00000128974 (from geneSymbol) uc333yti.1 uc333yti.1 
ENSMUST00000290983.1 ENSMUSG00000128975 ENSMUST00000290983.1 ENSMUSG00000128975 (from geneSymbol) AK144023 uc333ytj.1 uc333ytj.1 
ENSMUST00000290985.1 ENSMUSG00000128977 ENSMUST00000290985.1 ENSMUSG00000128977 (from geneSymbol) uc333ytk.1 uc333ytk.1 
ENSMUST00000290986.1 ENSMUSG00000128978 ENSMUST00000290986.1 ENSMUSG00000128978 (from geneSymbol) uc333ytl.1 uc333ytl.1 
ENSMUST00000290987.1 ENSMUSG00000128979 ENSMUST00000290987.1 ENSMUSG00000128979 (from geneSymbol) uc333ytm.1 uc333ytm.1 
ENSMUST00000290991.1 Gm12762 ENSMUST00000290991.1 Gm12762 (from geneSymbol) uc333ytq.1 uc333ytq.1 
ENSMUST00000290994.1 ENSMUSG00000128980 ENSMUST00000290994.1 ENSMUSG00000128980 (from geneSymbol) uc333ytt.1 uc333ytt.1 
ENSMUST00000291008.1 ENSMUSG00000128981 ENSMUST00000291008.1 ENSMUSG00000128981 (from geneSymbol) uc333yuh.1 uc333yuh.1 
ENSMUST00000291021.1 ENSMUSG00000128982 ENSMUST00000291021.1 ENSMUSG00000128982 (from geneSymbol) uc333yuu.1 uc333yuu.1 
ENSMUST00000291023.1 ENSMUSG00000128983 ENSMUST00000291023.1 ENSMUSG00000128983 (from geneSymbol) uc333yuw.1 uc333yuw.1 
ENSMUST00000291028.1 ENSMUSG00000128984 ENSMUST00000291028.1 ENSMUSG00000128984 (from geneSymbol) uc333yvb.1 uc333yvb.1 
ENSMUST00000291029.1 ENSMUSG00000128985 ENSMUST00000291029.1 ENSMUSG00000128985 (from geneSymbol) uc333yvc.1 uc333yvc.1 
ENSMUST00000291031.1 Gm28342 ENSMUST00000291031.1 Gm28342 (from geneSymbol) uc333yve.1 uc333yve.1 
ENSMUST00000291034.1 ENSMUSG00000128986 ENSMUST00000291034.1 ENSMUSG00000128986 (from geneSymbol) uc333yvh.1 uc333yvh.1 
ENSMUST00000291042.1 ENSMUSG00000128987 ENSMUST00000291042.1 ENSMUSG00000128987 (from geneSymbol) uc333yvp.1 uc333yvp.1 
ENSMUST00000291061.1 ENSMUSG00000128988 ENSMUST00000291061.1 ENSMUSG00000128988 (from geneSymbol) uc333ywi.1 uc333ywi.1 
ENSMUST00000291062.1 ENSMUSG00000128989 ENSMUST00000291062.1 ENSMUSG00000128989 (from geneSymbol) uc333ywj.1 uc333ywj.1 
ENSMUST00000291063.1 ENSMUSG00000128990 ENSMUST00000291063.1 ENSMUSG00000128990 (from geneSymbol) uc333ywk.1 uc333ywk.1 
ENSMUST00000291066.1 ENSMUSG00000128991 ENSMUST00000291066.1 ENSMUSG00000128991 (from geneSymbol) uc333ywn.1 uc333ywn.1 
ENSMUST00000291067.1 ENSMUSG00000128992 ENSMUST00000291067.1 ENSMUSG00000128992 (from geneSymbol) uc333ywo.1 uc333ywo.1 
ENSMUST00000291068.1 ENSMUSG00000128993 ENSMUST00000291068.1 ENSMUSG00000128993 (from geneSymbol) uc333ywp.1 uc333ywp.1 
ENSMUST00000291083.1 ENSMUSG00000128994 ENSMUST00000291083.1 ENSMUSG00000128994 (from geneSymbol) uc333yxe.1 uc333yxe.1 
ENSMUST00000291084.1 ENSMUSG00000128995 ENSMUST00000291084.1 ENSMUSG00000128995 (from geneSymbol) uc333yxf.1 uc333yxf.1 
ENSMUST00000291085.1 ENSMUSG00000128996 ENSMUST00000291085.1 ENSMUSG00000128996 (from geneSymbol) uc333yxg.1 uc333yxg.1 
ENSMUST00000291086.1 ENSMUSG00000128997 ENSMUST00000291086.1 ENSMUSG00000128997 (from geneSymbol) uc333yxh.1 uc333yxh.1 
ENSMUST00000291087.1 ENSMUSG00000128998 ENSMUST00000291087.1 ENSMUSG00000128998 (from geneSymbol) uc333yxi.1 uc333yxi.1 
ENSMUST00000291088.1 ENSMUSG00000128999 ENSMUST00000291088.1 ENSMUSG00000128999 (from geneSymbol) uc333yxj.1 uc333yxj.1 
ENSMUST00000291089.1 ENSMUSG00000129000 ENSMUST00000291089.1 ENSMUSG00000129000 (from geneSymbol) uc333yxk.1 uc333yxk.1 
ENSMUST00000291100.1 Gm32846 ENSMUST00000291100.1 Gm32846 (from geneSymbol) AK132898 uc333yxu.1 uc333yxu.1 
ENSMUST00000291113.1 Gm10714 ENSMUST00000291113.1 Gm10714 (from geneSymbol) AK141020 uc333yyh.1 uc333yyh.1 
ENSMUST00000291119.1 ENSMUSG00000129001 ENSMUST00000291119.1 ENSMUSG00000129001 (from geneSymbol) uc333yyn.1 uc333yyn.1 
ENSMUST00000291129.1 ENSMUSG00000129002 ENSMUST00000291129.1 ENSMUSG00000129002 (from geneSymbol) uc333yyx.1 uc333yyx.1 
ENSMUST00000291136.1 ENSMUSG00000129003 ENSMUST00000291136.1 ENSMUSG00000129003 (from geneSymbol) uc333yze.1 uc333yze.1 
ENSMUST00000291137.1 ENSMUSG00000129004 ENSMUST00000291137.1 ENSMUSG00000129004 (from geneSymbol) LF193683 uc333yzf.1 uc333yzf.1 
ENSMUST00000291143.1 ENSMUSG00000129005 ENSMUST00000291143.1 ENSMUSG00000129005 (from geneSymbol) uc333yzl.1 uc333yzl.1 
ENSMUST00000291146.1 ENSMUSG00000129006 ENSMUST00000291146.1 ENSMUSG00000129006 (from geneSymbol) uc333yzo.1 uc333yzo.1 
ENSMUST00000291147.1 4930449E18Rik ENSMUST00000291147.1 4930449E18Rik (from geneSymbol) AK019620 uc333yzp.1 uc333yzp.1 
ENSMUST00000291150.1 ENSMUSG00000129007 ENSMUST00000291150.1 ENSMUSG00000129007 (from geneSymbol) uc333yzs.1 uc333yzs.1 
ENSMUST00000291152.1 ENSMUSG00000129008 ENSMUST00000291152.1 ENSMUSG00000129008 (from geneSymbol) uc333yzu.1 uc333yzu.1 
ENSMUST00000291157.1 ENSMUSG00000129009 ENSMUST00000291157.1 ENSMUSG00000129009 (from geneSymbol) uc333yzz.1 uc333yzz.1 
ENSMUST00000291160.1 ENSMUSG00000129010 ENSMUST00000291160.1 ENSMUSG00000129010 (from geneSymbol) uc333zac.1 uc333zac.1 
ENSMUST00000291161.1 ENSMUSG00000129011 ENSMUST00000291161.1 ENSMUSG00000129011 (from geneSymbol) uc333zad.1 uc333zad.1 
ENSMUST00000291162.1 Gm32750 ENSMUST00000291162.1 Gm32750 (from geneSymbol) uc333zae.1 uc333zae.1 
ENSMUST00000291165.1 ENSMUSG00000129012 ENSMUST00000291165.1 ENSMUSG00000129012 (from geneSymbol) uc333zah.1 uc333zah.1 
ENSMUST00000291167.1 ENSMUSG00000129013 ENSMUST00000291167.1 ENSMUSG00000129013 (from geneSymbol) uc333zaj.1 uc333zaj.1 
ENSMUST00000291173.1 ENSMUSG00000129014 ENSMUST00000291173.1 ENSMUSG00000129014 (from geneSymbol) uc333zap.1 uc333zap.1 
ENSMUST00000291175.1 ENSMUSG00000129015 ENSMUST00000291175.1 ENSMUSG00000129015 (from geneSymbol) uc333zar.1 uc333zar.1 
ENSMUST00000291176.1 ENSMUSG00000129016 ENSMUST00000291176.1 ENSMUSG00000129016 (from geneSymbol) uc333zas.1 uc333zas.1 
ENSMUST00000291180.1 ENSMUSG00000129017 ENSMUST00000291180.1 ENSMUSG00000129017 (from geneSymbol) uc333zaw.1 uc333zaw.1 
ENSMUST00000291182.1 Gm37068 ENSMUST00000291182.1 Gm37068 (from geneSymbol) uc333zay.1 uc333zay.1 
ENSMUST00000291225.1 ENSMUSG00000129018 ENSMUST00000291225.1 ENSMUSG00000129018 (from geneSymbol) uc333zcp.1 uc333zcp.1 
ENSMUST00000291234.1 ENSMUSG00000129019 ENSMUST00000291234.1 ENSMUSG00000129019 (from geneSymbol) uc333zcy.1 uc333zcy.1 
ENSMUST00000291235.1 ENSMUSG00000129020 ENSMUST00000291235.1 ENSMUSG00000129020 (from geneSymbol) uc333zcz.1 uc333zcz.1 
ENSMUST00000291236.1 ENSMUSG00000129021 ENSMUST00000291236.1 ENSMUSG00000129021 (from geneSymbol) uc333zda.1 uc333zda.1 
ENSMUST00000291239.1 ENSMUSG00000129022 ENSMUST00000291239.1 ENSMUSG00000129022 (from geneSymbol) uc333zdd.1 uc333zdd.1 
ENSMUST00000291275.1 Gm49306 ENSMUST00000291275.1 Gm49306 (from geneSymbol) uc333zen.1 uc333zen.1 
ENSMUST00000291283.1 ENSMUSG00000129023 ENSMUST00000291283.1 ENSMUSG00000129023 (from geneSymbol) uc333zev.1 uc333zev.1 
ENSMUST00000291284.1 ENSMUSG00000129024 ENSMUST00000291284.1 ENSMUSG00000129024 (from geneSymbol) uc333zew.1 uc333zew.1 
ENSMUST00000291292.1 ENSMUSG00000129025 ENSMUST00000291292.1 ENSMUSG00000129025 (from geneSymbol) uc333zfe.1 uc333zfe.1 
ENSMUST00000291293.1 ENSMUSG00000129026 ENSMUST00000291293.1 ENSMUSG00000129026 (from geneSymbol) uc333zff.1 uc333zff.1 
ENSMUST00000291312.1 Gm30340 ENSMUST00000291312.1 Gm30340 (from geneSymbol) uc333zfy.1 uc333zfy.1 
ENSMUST00000291319.1 ENSMUSG00000129027 ENSMUST00000291319.1 ENSMUSG00000129027 (from geneSymbol) uc333zgf.1 uc333zgf.1 
ENSMUST00000291320.1 ENSMUSG00000129028 ENSMUST00000291320.1 ENSMUSG00000129028 (from geneSymbol) uc333zgg.1 uc333zgg.1 
ENSMUST00000291324.1 ENSMUSG00000129029 ENSMUST00000291324.1 ENSMUSG00000129029 (from geneSymbol) uc333zgk.1 uc333zgk.1 
ENSMUST00000291332.1 AV051173 ENSMUST00000291332.1 AV051173 (from geneSymbol) AK131819 uc333zgs.1 uc333zgs.1 
ENSMUST00000291344.1 ENSMUSG00000129031 ENSMUST00000291344.1 ENSMUSG00000129031 (from geneSymbol) uc333zhe.1 uc333zhe.1 
ENSMUST00000291355.1 ENSMUSG00000129032 ENSMUST00000291355.1 ENSMUSG00000129032 (from geneSymbol) uc333zhp.1 uc333zhp.1 
ENSMUST00000291359.1 ENSMUSG00000129033 ENSMUST00000291359.1 ENSMUSG00000129033 (from geneSymbol) uc333zht.1 uc333zht.1 
ENSMUST00000291360.1 ENSMUSG00000129034 ENSMUST00000291360.1 ENSMUSG00000129034 (from geneSymbol) uc333zhu.1 uc333zhu.1 
ENSMUST00000291361.1 ENSMUSG00000129035 ENSMUST00000291361.1 ENSMUSG00000129035 (from geneSymbol) uc333zhv.1 uc333zhv.1 
ENSMUST00000291362.1 ENSMUSG00000129036 ENSMUST00000291362.1 ENSMUSG00000129036 (from geneSymbol) uc333zhw.1 uc333zhw.1 
ENSMUST00000291364.1 ENSMUSG00000129037 ENSMUST00000291364.1 ENSMUSG00000129037 (from geneSymbol) uc333zhy.1 uc333zhy.1 
ENSMUST00000291366.1 Gm36617 ENSMUST00000291366.1 Gm36617 (from geneSymbol) AK015560 uc333zia.1 uc333zia.1 
ENSMUST00000291386.1 ENSMUSG00000121630 ENSMUST00000291386.1 ENSMUSG00000121630 (from geneSymbol) AK015560 uc333ziu.1 uc333ziu.1 
ENSMUST00000291418.1 Gm36372 ENSMUST00000291418.1 Gm36372 (from geneSymbol) uc333zka.1 uc333zka.1 
ENSMUST00000291435.1 ENSMUSG00000129038 ENSMUST00000291435.1 ENSMUSG00000129038 (from geneSymbol) uc333zkr.1 uc333zkr.1 
ENSMUST00000291436.1 ENSMUSG00000129039 ENSMUST00000291436.1 ENSMUSG00000129039 (from geneSymbol) uc333zks.1 uc333zks.1 
ENSMUST00000291439.1 ENSMUSG00000129040 ENSMUST00000291439.1 ENSMUSG00000129040 (from geneSymbol) uc333zkv.1 uc333zkv.1 
ENSMUST00000291440.1 ENSMUSG00000129041 ENSMUST00000291440.1 ENSMUSG00000129041 (from geneSymbol) uc333zkw.1 uc333zkw.1 
ENSMUST00000291443.1 ENSMUSG00000129042 ENSMUST00000291443.1 ENSMUSG00000129042 (from geneSymbol) uc333zkz.1 uc333zkz.1 
ENSMUST00000291445.1 ENSMUSG00000129043 ENSMUST00000291445.1 ENSMUSG00000129043 (from geneSymbol) uc333zlb.1 uc333zlb.1 
ENSMUST00000291446.1 ENSMUSG00000129044 ENSMUST00000291446.1 ENSMUSG00000129044 (from geneSymbol) uc333zlc.1 uc333zlc.1 
ENSMUST00000291447.1 ENSMUSG00000129045 ENSMUST00000291447.1 ENSMUSG00000129045 (from geneSymbol) uc333zld.1 uc333zld.1 
ENSMUST00000291451.1 Gm38839 ENSMUST00000291451.1 Gm38839 (from geneSymbol) uc333zlh.1 uc333zlh.1 
ENSMUST00000291464.1 ENSMUSG00000129046 ENSMUST00000291464.1 ENSMUSG00000129046 (from geneSymbol) uc333zlu.1 uc333zlu.1 
ENSMUST00000291469.1 ENSMUSG00000129047 ENSMUST00000291469.1 ENSMUSG00000129047 (from geneSymbol) uc333zlz.1 uc333zlz.1 
ENSMUST00000291471.1 Gm31651 ENSMUST00000291471.1 Gm31651 (from geneSymbol) uc333zmb.1 uc333zmb.1 
ENSMUST00000291472.1 ENSMUSG00000129048 ENSMUST00000291472.1 ENSMUSG00000129048 (from geneSymbol) uc333zmc.1 uc333zmc.1 
ENSMUST00000291474.1 ENSMUSG00000129049 ENSMUST00000291474.1 ENSMUSG00000129049 (from geneSymbol) uc333zme.1 uc333zme.1 
ENSMUST00000291475.1 ENSMUSG00000129050 ENSMUST00000291475.1 ENSMUSG00000129050 (from geneSymbol) uc333zmf.1 uc333zmf.1 
ENSMUST00000291478.1 ENSMUSG00000129051 ENSMUST00000291478.1 ENSMUSG00000129051 (from geneSymbol) uc333zmh.1 uc333zmh.1 
ENSMUST00000291481.1 Gm45430 ENSMUST00000291481.1 Gm45430 (from geneSymbol) uc333zmk.1 uc333zmk.1 
ENSMUST00000291500.1 ENSMUSG00000129052 ENSMUST00000291500.1 ENSMUSG00000129052 (from geneSymbol) uc333znd.1 uc333znd.1 
ENSMUST00000291501.1 ENSMUSG00000129053 ENSMUST00000291501.1 ENSMUSG00000129053 (from geneSymbol) uc333zne.1 uc333zne.1 
ENSMUST00000291503.1 ENSMUSG00000129054 ENSMUST00000291503.1 ENSMUSG00000129054 (from geneSymbol) uc333zng.1 uc333zng.1 
ENSMUST00000291509.1 ENSMUSG00000129055 ENSMUST00000291509.1 ENSMUSG00000129055 (from geneSymbol) uc333znm.1 uc333znm.1 
ENSMUST00000291522.1 ENSMUSG00000129056 ENSMUST00000291522.1 ENSMUSG00000129056 (from geneSymbol) uc333znz.1 uc333znz.1 
ENSMUST00000291526.1 ENSMUSG00000129057 ENSMUST00000291526.1 ENSMUSG00000129057 (from geneSymbol) uc333zod.1 uc333zod.1 
ENSMUST00000291529.1 ENSMUSG00000129058 ENSMUST00000291529.1 ENSMUSG00000129058 (from geneSymbol) uc333zog.1 uc333zog.1 
ENSMUST00000291537.1 ENSMUSG00000129059 ENSMUST00000291537.1 ENSMUSG00000129059 (from geneSymbol) uc333zoo.1 uc333zoo.1 
ENSMUST00000291538.1 ENSMUSG00000129060 ENSMUST00000291538.1 ENSMUSG00000129060 (from geneSymbol) uc333zop.1 uc333zop.1 
ENSMUST00000291539.1 ENSMUSG00000129061 ENSMUST00000291539.1 ENSMUSG00000129061 (from geneSymbol) uc333zoq.1 uc333zoq.1 
ENSMUST00000291540.1 ENSMUSG00000129062 ENSMUST00000291540.1 ENSMUSG00000129062 (from geneSymbol) uc333zor.1 uc333zor.1 
ENSMUST00000291541.1 ENSMUSG00000129063 ENSMUST00000291541.1 ENSMUSG00000129063 (from geneSymbol) uc333zos.1 uc333zos.1 
ENSMUST00000291544.1 Gm12596 ENSMUST00000291544.1 Gm12596 (from geneSymbol) AK143878 uc333zov.1 uc333zov.1 
ENSMUST00000291574.1 ENSMUSG00000129064 ENSMUST00000291574.1 ENSMUSG00000129064 (from geneSymbol) uc333zpz.1 uc333zpz.1 
ENSMUST00000291575.1 ENSMUSG00000129065 ENSMUST00000291575.1 ENSMUSG00000129065 (from geneSymbol) uc333zqa.1 uc333zqa.1 
ENSMUST00000291576.1 ENSMUSG00000129066 ENSMUST00000291576.1 ENSMUSG00000129066 (from geneSymbol) uc333zqb.1 uc333zqb.1 
ENSMUST00000291577.1 ENSMUSG00000129067 ENSMUST00000291577.1 ENSMUSG00000129067 (from geneSymbol) uc333zqc.1 uc333zqc.1 
ENSMUST00000291579.1 ENSMUSG00000129068 ENSMUST00000291579.1 ENSMUSG00000129068 (from geneSymbol) uc333zqe.1 uc333zqe.1 
ENSMUST00000291580.1 ENSMUSG00000129069 ENSMUST00000291580.1 ENSMUSG00000129069 (from geneSymbol) uc333zqf.1 uc333zqf.1 
ENSMUST00000291581.1 ENSMUSG00000129070 ENSMUST00000291581.1 ENSMUSG00000129070 (from geneSymbol) uc333zqg.1 uc333zqg.1 
ENSMUST00000291582.1 ENSMUSG00000129071 ENSMUST00000291582.1 ENSMUSG00000129071 (from geneSymbol) uc333zqh.1 uc333zqh.1 
ENSMUST00000291583.1 ENSMUSG00000129072 ENSMUST00000291583.1 ENSMUSG00000129072 (from geneSymbol) uc333zqi.1 uc333zqi.1 
ENSMUST00000291586.1 ENSMUSG00000129073 ENSMUST00000291586.1 ENSMUSG00000129073 (from geneSymbol) uc333zql.1 uc333zql.1 
ENSMUST00000291591.1 ENSMUSG00000129074 ENSMUST00000291591.1 ENSMUSG00000129074 (from geneSymbol) uc333zqq.1 uc333zqq.1 
ENSMUST00000291594.1 ENSMUSG00000129076 ENSMUST00000291594.1 ENSMUSG00000129076 (from geneSymbol) uc333zqs.1 uc333zqs.1 
ENSMUST00000291595.1 ENSMUSG00000129077 ENSMUST00000291595.1 ENSMUSG00000129077 (from geneSymbol) uc333zqt.1 uc333zqt.1 
ENSMUST00000291598.1 ENSMUSG00000129078 ENSMUST00000291598.1 ENSMUSG00000129078 (from geneSymbol) uc333zqw.1 uc333zqw.1 
ENSMUST00000291601.1 ENSMUSG00000129079 ENSMUST00000291601.1 ENSMUSG00000129079 (from geneSymbol) uc333zqz.1 uc333zqz.1 
ENSMUST00000291609.1 ENSMUSG00000129080 ENSMUST00000291609.1 ENSMUSG00000129080 (from geneSymbol) uc333zrh.1 uc333zrh.1 
ENSMUST00000291610.1 ENSMUSG00000129081 ENSMUST00000291610.1 ENSMUSG00000129081 (from geneSymbol) uc333zri.1 uc333zri.1 
ENSMUST00000291612.1 ENSMUSG00000129082 ENSMUST00000291612.1 ENSMUSG00000129082 (from geneSymbol) uc333zrk.1 uc333zrk.1 
ENSMUST00000291613.1 ENSMUSG00000129083 ENSMUST00000291613.1 ENSMUSG00000129083 (from geneSymbol) uc333zrl.1 uc333zrl.1 
ENSMUST00000291614.1 ENSMUSG00000129084 ENSMUST00000291614.1 ENSMUSG00000129084 (from geneSymbol) uc333zrm.1 uc333zrm.1 
ENSMUST00000291616.1 ENSMUSG00000129085 ENSMUST00000291616.1 ENSMUSG00000129085 (from geneSymbol) uc333zro.1 uc333zro.1 
ENSMUST00000291620.1 ENSMUSG00000129086 ENSMUST00000291620.1 ENSMUSG00000129086 (from geneSymbol) uc333zrs.1 uc333zrs.1 
ENSMUST00000291622.1 ENSMUSG00000129087 ENSMUST00000291622.1 ENSMUSG00000129087 (from geneSymbol) uc333zru.1 uc333zru.1 
ENSMUST00000291623.1 ENSMUSG00000129088 ENSMUST00000291623.1 ENSMUSG00000129088 (from geneSymbol) uc333zrv.1 uc333zrv.1 
ENSMUST00000291626.1 Gm45091 ENSMUST00000291626.1 Gm45091 (from geneSymbol) uc333zry.1 uc333zry.1 
ENSMUST00000291628.1 ENSMUSG00000129089 ENSMUST00000291628.1 ENSMUSG00000129089 (from geneSymbol) uc333zsa.1 uc333zsa.1 
ENSMUST00000291630.1 ENSMUSG00000129090 ENSMUST00000291630.1 ENSMUSG00000129090 (from geneSymbol) uc333zsc.1 uc333zsc.1 
ENSMUST00000291636.1 ENSMUSG00000129091 ENSMUST00000291636.1 ENSMUSG00000129091 (from geneSymbol) uc333zsi.1 uc333zsi.1 
ENSMUST00000291639.1 ENSMUSG00000129092 ENSMUST00000291639.1 ENSMUSG00000129092 (from geneSymbol) uc333zsl.1 uc333zsl.1 
ENSMUST00000291640.1 ENSMUSG00000129093 ENSMUST00000291640.1 ENSMUSG00000129093 (from geneSymbol) uc333zsm.1 uc333zsm.1 
ENSMUST00000291641.1 ENSMUSG00000129094 ENSMUST00000291641.1 ENSMUSG00000129094 (from geneSymbol) uc333zsn.1 uc333zsn.1 
ENSMUST00000291647.1 ENSMUSG00000129095 ENSMUST00000291647.1 ENSMUSG00000129095 (from geneSymbol) uc333zst.1 uc333zst.1 
ENSMUST00000291648.1 ENSMUSG00000129096 ENSMUST00000291648.1 ENSMUSG00000129096 (from geneSymbol) uc333zsu.1 uc333zsu.1 
ENSMUST00000291649.1 ENSMUSG00000129097 ENSMUST00000291649.1 ENSMUSG00000129097 (from geneSymbol) uc333zsv.1 uc333zsv.1 
ENSMUST00000291651.1 ENSMUSG00000129098 ENSMUST00000291651.1 ENSMUSG00000129098 (from geneSymbol) uc333zsx.1 uc333zsx.1 
ENSMUST00000291652.1 ENSMUSG00000129099 ENSMUST00000291652.1 ENSMUSG00000129099 (from geneSymbol) uc333zsy.1 uc333zsy.1 
ENSMUST00000291656.1 ENSMUSG00000129100 ENSMUST00000291656.1 ENSMUSG00000129100 (from geneSymbol) uc333ztc.1 uc333ztc.1 
ENSMUST00000291659.1 ENSMUSG00000129101 ENSMUST00000291659.1 ENSMUSG00000129101 (from geneSymbol) uc333ztf.1 uc333ztf.1 
ENSMUST00000291662.1 ENSMUSG00000129102 ENSMUST00000291662.1 ENSMUSG00000129102 (from geneSymbol) uc333zti.1 uc333zti.1 
ENSMUST00000291663.1 Gm15410 ENSMUST00000291663.1 Gm15410 (from geneSymbol) uc333ztj.1 uc333ztj.1 
ENSMUST00000291664.1 ENSMUSG00000129103 ENSMUST00000291664.1 ENSMUSG00000129103 (from geneSymbol) uc333ztk.1 uc333ztk.1 
ENSMUST00000291669.1 ENSMUSG00000129104 ENSMUST00000291669.1 ENSMUSG00000129104 (from geneSymbol) uc333ztp.1 uc333ztp.1 
ENSMUST00000291670.1 ENSMUSG00000129105 ENSMUST00000291670.1 ENSMUSG00000129105 (from geneSymbol) uc333ztq.1 uc333ztq.1 
ENSMUST00000291672.1 ENSMUSG00000129106 ENSMUST00000291672.1 ENSMUSG00000129106 (from geneSymbol) uc333zts.1 uc333zts.1 
ENSMUST00000291678.1 ENSMUSG00000129107 ENSMUST00000291678.1 ENSMUSG00000129107 (from geneSymbol) uc333zty.1 uc333zty.1 
ENSMUST00000291680.1 ENSMUSG00000129108 ENSMUST00000291680.1 ENSMUSG00000129108 (from geneSymbol) uc333ztz.1 uc333ztz.1 
ENSMUST00000291681.1 ENSMUSG00000129109 ENSMUST00000291681.1 ENSMUSG00000129109 (from geneSymbol) uc333zua.1 uc333zua.1 
ENSMUST00000291682.1 ENSMUSG00000129110 ENSMUST00000291682.1 ENSMUSG00000129110 (from geneSymbol) uc333zub.1 uc333zub.1 
ENSMUST00000291683.1 ENSMUSG00000129111 ENSMUST00000291683.1 ENSMUSG00000129111 (from geneSymbol) uc333zuc.1 uc333zuc.1 
ENSMUST00000291686.1 ENSMUSG00000129112 ENSMUST00000291686.1 ENSMUSG00000129112 (from geneSymbol) uc333zuf.1 uc333zuf.1 
ENSMUST00000291689.1 ENSMUSG00000129113 ENSMUST00000291689.1 ENSMUSG00000129113 (from geneSymbol) uc333zui.1 uc333zui.1 
ENSMUST00000291694.1 ENSMUSG00000129114 ENSMUST00000291694.1 ENSMUSG00000129114 (from geneSymbol) uc333zun.1 uc333zun.1 
ENSMUST00000291696.1 ENSMUSG00000129115 ENSMUST00000291696.1 ENSMUSG00000129115 (from geneSymbol) uc333zup.1 uc333zup.1 
ENSMUST00000291697.1 ENSMUSG00000129116 ENSMUST00000291697.1 ENSMUSG00000129116 (from geneSymbol) uc333zuq.1 uc333zuq.1 
ENSMUST00000291698.1 ENSMUSG00000129117 ENSMUST00000291698.1 ENSMUSG00000129117 (from geneSymbol) uc333zur.1 uc333zur.1 
ENSMUST00000291702.1 ENSMUSG00000129118 ENSMUST00000291702.1 ENSMUSG00000129118 (from geneSymbol) uc333zuv.1 uc333zuv.1 
ENSMUST00000291704.1 ENSMUSG00000129119 ENSMUST00000291704.1 ENSMUSG00000129119 (from geneSymbol) uc333zux.1 uc333zux.1 
ENSMUST00000291712.1 ENSMUSG00000129120 ENSMUST00000291712.1 ENSMUSG00000129120 (from geneSymbol) uc333zvf.1 uc333zvf.1 
ENSMUST00000291713.1 ENSMUSG00000129121 ENSMUST00000291713.1 ENSMUSG00000129121 (from geneSymbol) BC019681 uc333zvg.1 uc333zvg.1 
ENSMUST00000291714.1 ENSMUSG00000129122 ENSMUST00000291714.1 ENSMUSG00000129122 (from geneSymbol) uc333zvh.1 uc333zvh.1 
ENSMUST00000291715.1 ENSMUSG00000129123 ENSMUST00000291715.1 ENSMUSG00000129123 (from geneSymbol) DQ714074 uc333zvi.1 uc333zvi.1 
ENSMUST00000291721.1 ENSMUSG00000129124 ENSMUST00000291721.1 ENSMUSG00000129124 (from geneSymbol) uc333zvo.1 uc333zvo.1 
ENSMUST00000291736.1 ENSMUSG00000129125 ENSMUST00000291736.1 ENSMUSG00000129125 (from geneSymbol) uc333zwd.1 uc333zwd.1 
ENSMUST00000291738.1 ENSMUSG00000129126 ENSMUST00000291738.1 ENSMUSG00000129126 (from geneSymbol) uc333zwf.1 uc333zwf.1 
ENSMUST00000291739.1 ENSMUSG00000129127 ENSMUST00000291739.1 ENSMUSG00000129127 (from geneSymbol) uc333zwg.1 uc333zwg.1 
ENSMUST00000291741.1 ENSMUSG00000129128 ENSMUST00000291741.1 ENSMUSG00000129128 (from geneSymbol) uc333zwi.1 uc333zwi.1 
ENSMUST00000291742.1 ENSMUSG00000129129 ENSMUST00000291742.1 ENSMUSG00000129129 (from geneSymbol) uc333zwj.1 uc333zwj.1 
ENSMUST00000291745.1 ENSMUSG00000129130 ENSMUST00000291745.1 ENSMUSG00000129130 (from geneSymbol) uc333zwm.1 uc333zwm.1 
ENSMUST00000291746.1 ENSMUSG00000129131 ENSMUST00000291746.1 ENSMUSG00000129131 (from geneSymbol) uc333zwn.1 uc333zwn.1 
ENSMUST00000291747.1 ENSMUSG00000129132 ENSMUST00000291747.1 ENSMUSG00000129132 (from geneSymbol) uc333zwo.1 uc333zwo.1 
ENSMUST00000291755.1 ENSMUSG00000129133 ENSMUST00000291755.1 ENSMUSG00000129133 (from geneSymbol) uc333zwt.1 uc333zwt.1 
ENSMUST00000291756.1 ENSMUSG00000129134 ENSMUST00000291756.1 ENSMUSG00000129134 (from geneSymbol) uc333zwu.1 uc333zwu.1 
ENSMUST00000291757.1 ENSMUSG00000129135 ENSMUST00000291757.1 ENSMUSG00000129135 (from geneSymbol) uc333zwv.1 uc333zwv.1 
ENSMUST00000291758.1 ENSMUSG00000129136 ENSMUST00000291758.1 ENSMUSG00000129136 (from geneSymbol) uc333zww.1 uc333zww.1 
ENSMUST00000291776.1 Gm56763 ENSMUST00000291776.1 Gm56763 (from geneSymbol) uc333zxo.1 uc333zxo.1 
ENSMUST00000291779.1 ENSMUSG00000129137 ENSMUST00000291779.1 ENSMUSG00000129137 (from geneSymbol) uc333zxr.1 uc333zxr.1 
ENSMUST00000291781.1 ENSMUSG00000129138 ENSMUST00000291781.1 ENSMUSG00000129138 (from geneSymbol) uc333zxt.1 uc333zxt.1 
ENSMUST00000291782.1 ENSMUSG00000129139 ENSMUST00000291782.1 ENSMUSG00000129139 (from geneSymbol) uc333zxu.1 uc333zxu.1 
ENSMUST00000291783.1 ENSMUSG00000129140 ENSMUST00000291783.1 ENSMUSG00000129140 (from geneSymbol) uc333zxv.1 uc333zxv.1 
ENSMUST00000291787.1 Gm49048 ENSMUST00000291787.1 Gm49048 (from geneSymbol) uc333zxz.1 uc333zxz.1 
ENSMUST00000291789.1 ENSMUSG00000129141 ENSMUST00000291789.1 ENSMUSG00000129141 (from geneSymbol) uc333zyb.1 uc333zyb.1 
ENSMUST00000291798.1 ENSMUSG00000129142 ENSMUST00000291798.1 ENSMUSG00000129142 (from geneSymbol) uc333zyk.1 uc333zyk.1 
ENSMUST00000291801.1 ENSMUSG00000129143 ENSMUST00000291801.1 ENSMUSG00000129143 (from geneSymbol) uc333zyn.1 uc333zyn.1 
ENSMUST00000291802.1 ENSMUSG00000129144 ENSMUST00000291802.1 ENSMUSG00000129144 (from geneSymbol) uc333zyo.1 uc333zyo.1 
ENSMUST00000291803.1 ENSMUSG00000129145 ENSMUST00000291803.1 ENSMUSG00000129145 (from geneSymbol) uc333zyp.1 uc333zyp.1 
ENSMUST00000291804.1 ENSMUSG00000129146 ENSMUST00000291804.1 ENSMUSG00000129146 (from geneSymbol) uc333zyq.1 uc333zyq.1 
ENSMUST00000291806.1 ENSMUSG00000129147 ENSMUST00000291806.1 ENSMUSG00000129147 (from geneSymbol) uc333zys.1 uc333zys.1 
ENSMUST00000291808.1 ENSMUSG00000129149 ENSMUST00000291808.1 ENSMUSG00000129149 (from geneSymbol) uc333zyt.1 uc333zyt.1 
ENSMUST00000291814.1 ENSMUSG00000129152 ENSMUST00000291814.1 ENSMUSG00000129152 (from geneSymbol) uc333zyx.1 uc333zyx.1 
ENSMUST00000291819.1 Gm13710 ENSMUST00000291819.1 Gm13710 (from geneSymbol) AK044106 uc333zzc.1 uc333zzc.1 
ENSMUST00000291827.1 ENSMUSG00000129153 ENSMUST00000291827.1 ENSMUSG00000129153 (from geneSymbol) uc333zzk.1 uc333zzk.1 
ENSMUST00000291840.1 ENSMUSG00000129154 ENSMUST00000291840.1 ENSMUSG00000129154 (from geneSymbol) uc333zzx.1 uc333zzx.1 
ENSMUST00000291844.1 ENSMUSG00000129155 ENSMUST00000291844.1 ENSMUSG00000129155 (from geneSymbol) uc334aab.1 uc334aab.1 
ENSMUST00000291845.1 ENSMUSG00000129156 ENSMUST00000291845.1 ENSMUSG00000129156 (from geneSymbol) uc334aac.1 uc334aac.1 
ENSMUST00000291847.1 ENSMUSG00000129157 ENSMUST00000291847.1 ENSMUSG00000129157 (from geneSymbol) uc334aae.1 uc334aae.1 
ENSMUST00000291848.1 ENSMUSG00000129158 ENSMUST00000291848.1 ENSMUSG00000129158 (from geneSymbol) uc334aaf.1 uc334aaf.1 
ENSMUST00000291849.1 ENSMUSG00000129159 ENSMUST00000291849.1 ENSMUSG00000129159 (from geneSymbol) uc334aag.1 uc334aag.1 
ENSMUST00000291867.1 1700074H08Rik ENSMUST00000291867.1 1700074H08Rik (from geneSymbol) AK006947 uc334aay.1 uc334aay.1 
ENSMUST00000291881.1 Gm10825 ENSMUST00000291881.1 Gm10825 (from geneSymbol) AK148310 uc334abm.1 uc334abm.1 
ENSMUST00000291890.1 ENSMUSG00000129160 ENSMUST00000291890.1 ENSMUSG00000129160 (from geneSymbol) uc334abv.1 uc334abv.1 
ENSMUST00000291891.1 ENSMUSG00000129161 ENSMUST00000291891.1 ENSMUSG00000129161 (from geneSymbol) uc334abw.1 uc334abw.1 
ENSMUST00000291897.1 Gm48691 ENSMUST00000291897.1 Gm48691 (from geneSymbol) uc334acc.1 uc334acc.1 
ENSMUST00000291900.1 ENSMUSG00000129162 ENSMUST00000291900.1 ENSMUSG00000129162 (from geneSymbol) uc334acf.1 uc334acf.1 
ENSMUST00000291906.1 ENSMUSG00000129163 ENSMUST00000291906.1 ENSMUSG00000129163 (from geneSymbol) uc334ack.1 uc334ack.1 
ENSMUST00000291913.1 ENSMUSG00000129164 ENSMUST00000291913.1 ENSMUSG00000129164 (from geneSymbol) uc334acl.1 uc334acl.1 
ENSMUST00000291917.1 ENSMUSG00000129165 ENSMUST00000291917.1 ENSMUSG00000129165 (from geneSymbol) uc334acp.1 uc334acp.1 
ENSMUST00000291938.1 ENSMUSG00000129166 ENSMUST00000291938.1 ENSMUSG00000129166 (from geneSymbol) uc334adk.1 uc334adk.1 
ENSMUST00000291940.1 ENSMUSG00000129167 ENSMUST00000291940.1 ENSMUSG00000129167 (from geneSymbol) uc334adm.1 uc334adm.1 
ENSMUST00000291942.1 ENSMUSG00000129168 ENSMUST00000291942.1 ENSMUSG00000129168 (from geneSymbol) uc334ado.1 uc334ado.1 
ENSMUST00000291945.1 ENSMUSG00000129169 ENSMUST00000291945.1 ENSMUSG00000129169 (from geneSymbol) uc334adr.1 uc334adr.1 
ENSMUST00000291946.1 ENSMUSG00000129170 ENSMUST00000291946.1 ENSMUSG00000129170 (from geneSymbol) uc334ads.1 uc334ads.1 
ENSMUST00000291951.1 ENSMUSG00000129171 ENSMUST00000291951.1 ENSMUSG00000129171 (from geneSymbol) uc334adx.1 uc334adx.1 
ENSMUST00000291981.1 ENSMUSG00000129172 ENSMUST00000291981.1 ENSMUSG00000129172 (from geneSymbol) uc334aeu.1 uc334aeu.1 
ENSMUST00000292005.1 ENSMUSG00000129173 ENSMUST00000292005.1 ENSMUSG00000129173 (from geneSymbol) uc334afs.1 uc334afs.1 
ENSMUST00000292006.1 ENSMUSG00000129174 ENSMUST00000292006.1 ENSMUSG00000129174 (from geneSymbol) uc334aft.1 uc334aft.1 
ENSMUST00000292009.1 ENSMUSG00000129176 ENSMUST00000292009.1 ENSMUSG00000129176 (from geneSymbol) uc334afv.1 uc334afv.1 
ENSMUST00000292010.1 ENSMUSG00000129177 ENSMUST00000292010.1 ENSMUSG00000129177 (from geneSymbol) uc334afw.1 uc334afw.1 
ENSMUST00000292037.1 ENSMUSG00000129178 ENSMUST00000292037.1 ENSMUSG00000129178 (from geneSymbol) uc334agx.1 uc334agx.1 
ENSMUST00000292038.1 ENSMUSG00000129179 ENSMUST00000292038.1 ENSMUSG00000129179 (from geneSymbol) uc334agy.1 uc334agy.1 
ENSMUST00000292040.1 4930511A02Rik ENSMUST00000292040.1 4930511A02Rik (from geneSymbol) AK133134 uc334aha.1 uc334aha.1 
ENSMUST00000292045.1 ENSMUSG00000129180 ENSMUST00000292045.1 ENSMUSG00000129180 (from geneSymbol) uc334ahf.1 uc334ahf.1 
ENSMUST00000292046.1 ENSMUSG00000129181 ENSMUST00000292046.1 ENSMUSG00000129181 (from geneSymbol) uc334ahg.1 uc334ahg.1 
ENSMUST00000292047.1 ENSMUSG00000129182 ENSMUST00000292047.1 ENSMUSG00000129182 (from geneSymbol) uc334ahh.1 uc334ahh.1 
ENSMUST00000292052.1 ENSMUSG00000129183 ENSMUST00000292052.1 ENSMUSG00000129183 (from geneSymbol) uc334ahm.1 uc334ahm.1 
ENSMUST00000292054.1 Gm12162 ENSMUST00000292054.1 Gm12162 (from geneSymbol) uc334aho.1 uc334aho.1 
ENSMUST00000292055.1 ENSMUSG00000129184 ENSMUST00000292055.1 ENSMUSG00000129184 (from geneSymbol) uc334ahp.1 uc334ahp.1 
ENSMUST00000292056.1 ENSMUSG00000129185 ENSMUST00000292056.1 ENSMUSG00000129185 (from geneSymbol) uc334ahq.1 uc334ahq.1 
ENSMUST00000292057.1 ENSMUSG00000129186 ENSMUST00000292057.1 ENSMUSG00000129186 (from geneSymbol) uc334ahr.1 uc334ahr.1 
ENSMUST00000292059.1 ENSMUSG00000129188 ENSMUST00000292059.1 ENSMUSG00000129188 (from geneSymbol) uc334ahs.1 uc334ahs.1 
ENSMUST00000292060.1 ENSMUSG00000129189 ENSMUST00000292060.1 ENSMUSG00000129189 (from geneSymbol) uc334aht.1 uc334aht.1 
ENSMUST00000292065.1 ENSMUSG00000129190 ENSMUST00000292065.1 ENSMUSG00000129190 (from geneSymbol) uc334ahy.1 uc334ahy.1 
ENSMUST00000292072.1 ENSMUSG00000129191 ENSMUST00000292072.1 ENSMUSG00000129191 (from geneSymbol) uc334aif.1 uc334aif.1 
ENSMUST00000292073.1 A330009N23Rik ENSMUST00000292073.1 A330009N23Rik (from geneSymbol) AK039268 uc334aig.1 uc334aig.1 
ENSMUST00000292089.1 ENSMUSG00000129192 ENSMUST00000292089.1 ENSMUSG00000129192 (from geneSymbol) uc334aiw.1 uc334aiw.1 
ENSMUST00000292092.1 ENSMUSG00000129193 ENSMUST00000292092.1 ENSMUSG00000129193 (from geneSymbol) uc334aiz.1 uc334aiz.1 
ENSMUST00000292097.1 ENSMUSG00000129195 ENSMUST00000292097.1 ENSMUSG00000129195 (from geneSymbol) uc334ajd.1 uc334ajd.1 
ENSMUST00000292098.1 ENSMUSG00000129196 ENSMUST00000292098.1 ENSMUSG00000129196 (from geneSymbol) uc334aje.1 uc334aje.1 
ENSMUST00000292101.1 ENSMUSG00000129197 ENSMUST00000292101.1 ENSMUSG00000129197 (from geneSymbol) uc334ajh.1 uc334ajh.1 
ENSMUST00000292103.1 ENSMUSG00000129198 ENSMUST00000292103.1 ENSMUSG00000129198 (from geneSymbol) uc334ajj.1 uc334ajj.1 
ENSMUST00000292105.1 ENSMUSG00000129199 ENSMUST00000292105.1 ENSMUSG00000129199 (from geneSymbol) uc334ajl.1 uc334ajl.1 
ENSMUST00000292109.1 ENSMUSG00000129200 ENSMUST00000292109.1 ENSMUSG00000129200 (from geneSymbol) uc334ajp.1 uc334ajp.1 
ENSMUST00000292113.1 ENSMUSG00000129201 ENSMUST00000292113.1 ENSMUSG00000129201 (from geneSymbol) uc334ajt.1 uc334ajt.1 
ENSMUST00000292115.1 Gm20478 ENSMUST00000292115.1 Gm20478 (from geneSymbol) uc334ajv.1 uc334ajv.1 
ENSMUST00000292120.1 ENSMUSG00000129202 ENSMUST00000292120.1 ENSMUSG00000129202 (from geneSymbol) uc334aka.1 uc334aka.1 
ENSMUST00000292121.1 ENSMUSG00000129203 ENSMUST00000292121.1 ENSMUSG00000129203 (from geneSymbol) uc334akb.1 uc334akb.1 
ENSMUST00000292124.1 ENSMUSG00000129204 ENSMUST00000292124.1 ENSMUSG00000129204 (from geneSymbol) uc334ake.1 uc334ake.1 
ENSMUST00000292125.1 ENSMUSG00000129205 ENSMUST00000292125.1 ENSMUSG00000129205 (from geneSymbol) uc334akf.1 uc334akf.1 
ENSMUST00000292127.1 ENSMUSG00000129206 ENSMUST00000292127.1 ENSMUSG00000129206 (from geneSymbol) uc334akh.1 uc334akh.1 
ENSMUST00000292128.1 ENSMUSG00000129207 ENSMUST00000292128.1 ENSMUSG00000129207 (from geneSymbol) uc334aki.1 uc334aki.1 
ENSMUST00000292129.1 ENSMUSG00000129208 ENSMUST00000292129.1 ENSMUSG00000129208 (from geneSymbol) uc334akj.1 uc334akj.1 
ENSMUST00000292130.1 ENSMUSG00000129209 ENSMUST00000292130.1 ENSMUSG00000129209 (from geneSymbol) uc334akk.1 uc334akk.1 
ENSMUST00000292131.1 ENSMUSG00000129210 ENSMUST00000292131.1 ENSMUSG00000129210 (from geneSymbol) uc334akl.1 uc334akl.1 
ENSMUST00000292134.1 Gm33070 ENSMUST00000292134.1 Gm33070 (from geneSymbol) uc334ako.1 uc334ako.1 
ENSMUST00000292150.1 ENSMUSG00000129212 ENSMUST00000292150.1 ENSMUSG00000129212 (from geneSymbol) uc334ale.1 uc334ale.1 
ENSMUST00000292156.1 ENSMUSG00000129213 ENSMUST00000292156.1 ENSMUSG00000129213 (from geneSymbol) uc334alk.1 uc334alk.1 
ENSMUST00000292158.1 ENSMUSG00000129214 ENSMUST00000292158.1 ENSMUSG00000129214 (from geneSymbol) uc334alm.1 uc334alm.1 
ENSMUST00000292160.1 ENSMUSG00000129215 ENSMUST00000292160.1 ENSMUSG00000129215 (from geneSymbol) uc334alo.1 uc334alo.1 
ENSMUST00000292164.1 ENSMUSG00000129216 ENSMUST00000292164.1 ENSMUSG00000129216 (from geneSymbol) uc334als.1 uc334als.1 
ENSMUST00000292165.1 ENSMUSG00000129217 ENSMUST00000292165.1 ENSMUSG00000129217 (from geneSymbol) uc334alt.1 uc334alt.1 
ENSMUST00000292172.1 ENSMUSG00000129218 ENSMUST00000292172.1 ENSMUSG00000129218 (from geneSymbol) uc334ama.1 uc334ama.1 
ENSMUST00000292183.1 Phf2os1 ENSMUST00000292183.1 Phf2os1 (from geneSymbol) uc334aml.1 uc334aml.1 
ENSMUST00000292198.1 ENSMUSG00000129219 ENSMUST00000292198.1 ENSMUSG00000129219 (from geneSymbol) uc334ana.1 uc334ana.1 
ENSMUST00000292202.1 ENSMUSG00000129220 ENSMUST00000292202.1 ENSMUSG00000129220 (from geneSymbol) uc334ane.1 uc334ane.1 
ENSMUST00000292206.1 ENSMUSG00000129221 ENSMUST00000292206.1 ENSMUSG00000129221 (from geneSymbol) uc334ani.1 uc334ani.1 
ENSMUST00000292207.1 ENSMUSG00000129222 ENSMUST00000292207.1 ENSMUSG00000129222 (from geneSymbol) AK146672 uc334anj.1 uc334anj.1 
ENSMUST00000292211.1 ENSMUSG00000129223 ENSMUST00000292211.1 ENSMUSG00000129223 (from geneSymbol) uc334ann.1 uc334ann.1 
ENSMUST00000292212.1 ENSMUSG00000129224 ENSMUST00000292212.1 ENSMUSG00000129224 (from geneSymbol) uc334ano.1 uc334ano.1 
ENSMUST00000292214.1 ENSMUSG00000129225 ENSMUST00000292214.1 ENSMUSG00000129225 (from geneSymbol) uc334anq.1 uc334anq.1 
ENSMUST00000292215.1 ENSMUSG00000129226 ENSMUST00000292215.1 ENSMUSG00000129226 (from geneSymbol) uc334anr.1 uc334anr.1 
ENSMUST00000292216.1 ENSMUSG00000129227 ENSMUST00000292216.1 ENSMUSG00000129227 (from geneSymbol) uc334ans.1 uc334ans.1 
ENSMUST00000292223.1 Gm30504 ENSMUST00000292223.1 Gm30504 (from geneSymbol) uc334anz.1 uc334anz.1 
ENSMUST00000292244.1 ENSMUSG00000129228 ENSMUST00000292244.1 ENSMUSG00000129228 (from geneSymbol) uc334aou.1 uc334aou.1 
ENSMUST00000292245.1 ENSMUSG00000129229 ENSMUST00000292245.1 ENSMUSG00000129229 (from geneSymbol) uc334aov.1 uc334aov.1 
ENSMUST00000292246.1 ENSMUSG00000129230 ENSMUST00000292246.1 ENSMUSG00000129230 (from geneSymbol) KY468105 uc334aow.1 uc334aow.1 
ENSMUST00000292248.1 ENSMUSG00000129231 ENSMUST00000292248.1 ENSMUSG00000129231 (from geneSymbol) uc334aoy.1 uc334aoy.1 
ENSMUST00000292249.1 ENSMUSG00000129232 ENSMUST00000292249.1 ENSMUSG00000129232 (from geneSymbol) uc334aoz.1 uc334aoz.1 
ENSMUST00000292250.1 ENSMUSG00000129233 ENSMUST00000292250.1 ENSMUSG00000129233 (from geneSymbol) uc334apa.1 uc334apa.1 
ENSMUST00000292253.1 ENSMUSG00000129234 ENSMUST00000292253.1 ENSMUSG00000129234 (from geneSymbol) uc334apd.1 uc334apd.1 
ENSMUST00000292283.1 ENSMUSG00000129235 ENSMUST00000292283.1 ENSMUSG00000129235 (from geneSymbol) uc334aqh.1 uc334aqh.1 
ENSMUST00000292285.1 ENSMUSG00000129236 ENSMUST00000292285.1 ENSMUSG00000129236 (from geneSymbol) uc334aqj.1 uc334aqj.1 
ENSMUST00000292286.1 ENSMUSG00000129237 ENSMUST00000292286.1 ENSMUSG00000129237 (from geneSymbol) uc334aqk.1 uc334aqk.1 
ENSMUST00000292287.1 ENSMUSG00000129238 ENSMUST00000292287.1 ENSMUSG00000129238 (from geneSymbol) uc334aql.1 uc334aql.1 
ENSMUST00000292294.1 ENSMUSG00000129239 ENSMUST00000292294.1 ENSMUSG00000129239 (from geneSymbol) uc334aqs.1 uc334aqs.1 
ENSMUST00000292295.1 ENSMUSG00000129240 ENSMUST00000292295.1 ENSMUSG00000129240 (from geneSymbol) uc334aqt.1 uc334aqt.1 
ENSMUST00000292296.1 ENSMUSG00000129241 ENSMUST00000292296.1 ENSMUSG00000129241 (from geneSymbol) uc334aqu.1 uc334aqu.1 
ENSMUST00000292300.1 ENSMUSG00000129242 ENSMUST00000292300.1 ENSMUSG00000129242 (from geneSymbol) uc334aqy.1 uc334aqy.1 
ENSMUST00000292309.1 ENSMUSG00000129243 ENSMUST00000292309.1 ENSMUSG00000129243 (from geneSymbol) uc334arg.1 uc334arg.1 
ENSMUST00000292325.1 ENSMUSG00000129244 ENSMUST00000292325.1 ENSMUSG00000129244 (from geneSymbol) uc334arw.1 uc334arw.1 
ENSMUST00000292338.1 ENSMUSG00000129245 ENSMUST00000292338.1 ENSMUSG00000129245 (from geneSymbol) uc334asj.1 uc334asj.1 
ENSMUST00000292353.1 ENSMUSG00000129246 ENSMUST00000292353.1 ENSMUSG00000129246 (from geneSymbol) uc334asy.1 uc334asy.1 
ENSMUST00000292354.1 ENSMUSG00000129247 ENSMUST00000292354.1 ENSMUSG00000129247 (from geneSymbol) uc334asz.1 uc334asz.1 
ENSMUST00000292358.1 4933431E20Rik ENSMUST00000292358.1 4933431E20Rik (from geneSymbol) uc334atd.1 uc334atd.1 
ENSMUST00000292374.1 ENSMUSG00000129250 ENSMUST00000292374.1 ENSMUSG00000129250 (from geneSymbol) uc334ats.1 uc334ats.1 
ENSMUST00000292377.1 ENSMUSG00000129249 ENSMUST00000292377.1 ENSMUSG00000129249 (from geneSymbol) uc334atv.1 uc334atv.1 
ENSMUST00000292381.1 ENSMUSG00000129251 ENSMUST00000292381.1 ENSMUSG00000129251 (from geneSymbol) uc334atz.1 uc334atz.1 
ENSMUST00000292384.1 ENSMUSG00000129252 ENSMUST00000292384.1 ENSMUSG00000129252 (from geneSymbol) uc334auc.1 uc334auc.1 
ENSMUST00000292397.1 1700028M03Rik ENSMUST00000292397.1 1700028M03Rik (from geneSymbol) AK006465 uc334aup.1 uc334aup.1 
ENSMUST00000292408.1 ENSMUSG00000129253 ENSMUST00000292408.1 ENSMUSG00000129253 (from geneSymbol) uc334ava.1 uc334ava.1 
ENSMUST00000292410.1 ENSMUSG00000129254 ENSMUST00000292410.1 ENSMUSG00000129254 (from geneSymbol) uc334avc.1 uc334avc.1 
ENSMUST00000292411.1 ENSMUSG00000129255 ENSMUST00000292411.1 ENSMUSG00000129255 (from geneSymbol) uc334avd.1 uc334avd.1 
ENSMUST00000292412.1 ENSMUSG00000129256 ENSMUST00000292412.1 ENSMUSG00000129256 (from geneSymbol) uc334ave.1 uc334ave.1 
ENSMUST00000292413.1 B230216N24Rik ENSMUST00000292413.1 B230216N24Rik (from geneSymbol) AK021003 uc334avf.1 uc334avf.1 
ENSMUST00000292418.1 ENSMUSG00000129257 ENSMUST00000292418.1 ENSMUSG00000129257 (from geneSymbol) uc334avk.1 uc334avk.1 
ENSMUST00000292420.1 ENSMUSG00000129258 ENSMUST00000292420.1 ENSMUSG00000129258 (from geneSymbol) uc334avm.1 uc334avm.1 
ENSMUST00000292423.1 ENSMUSG00000129259 ENSMUST00000292423.1 ENSMUSG00000129259 (from geneSymbol) uc334avp.1 uc334avp.1 
ENSMUST00000292427.1 ENSMUSG00000129261 ENSMUST00000292427.1 ENSMUSG00000129261 (from geneSymbol) uc334avs.1 uc334avs.1 
ENSMUST00000292428.1 ENSMUSG00000129262 ENSMUST00000292428.1 ENSMUSG00000129262 (from geneSymbol) uc334avt.1 uc334avt.1 
ENSMUST00000292429.1 ENSMUSG00000129263 ENSMUST00000292429.1 ENSMUSG00000129263 (from geneSymbol) uc334avu.1 uc334avu.1 
ENSMUST00000292433.1 ENSMUSG00000129264 ENSMUST00000292433.1 ENSMUSG00000129264 (from geneSymbol) uc334avy.1 uc334avy.1 
ENSMUST00000292437.1 ENSMUSG00000129265 ENSMUST00000292437.1 ENSMUSG00000129265 (from geneSymbol) uc334awc.1 uc334awc.1 
ENSMUST00000292445.1 Gm56614 ENSMUST00000292445.1 Gm56614 (from geneSymbol) uc334awk.1 uc334awk.1 
ENSMUST00000292456.1 ENSMUSG00000129266 ENSMUST00000292456.1 ENSMUSG00000129266 (from geneSymbol) uc334awo.1 uc334awo.1 
ENSMUST00000292459.1 ENSMUSG00000129267 ENSMUST00000292459.1 ENSMUSG00000129267 (from geneSymbol) uc334awr.1 uc334awr.1 
ENSMUST00000292498.1 ENSMUSG00000129268 ENSMUST00000292498.1 ENSMUSG00000129268 (from geneSymbol) uc334aye.1 uc334aye.1 
ENSMUST00000292499.1 ENSMUSG00000129269 ENSMUST00000292499.1 ENSMUSG00000129269 (from geneSymbol) uc334ayf.1 uc334ayf.1 
ENSMUST00000292500.1 ENSMUSG00000129270 ENSMUST00000292500.1 ENSMUSG00000129270 (from geneSymbol) uc334ayg.1 uc334ayg.1 
ENSMUST00000292501.1 ENSMUSG00000129271 ENSMUST00000292501.1 ENSMUSG00000129271 (from geneSymbol) uc334ayh.1 uc334ayh.1 
ENSMUST00000292502.1 ENSMUSG00000129272 ENSMUST00000292502.1 ENSMUSG00000129272 (from geneSymbol) uc334ayi.1 uc334ayi.1 
ENSMUST00000292503.1 1700063H04Rik ENSMUST00000292503.1 1700063H04Rik (from geneSymbol) AK006869 uc334ayj.1 uc334ayj.1 
ENSMUST00000292543.1 ENSMUSG00000129273 ENSMUST00000292543.1 ENSMUSG00000129273 (from geneSymbol) uc334azx.1 uc334azx.1 
ENSMUST00000292546.1 Gm37173 ENSMUST00000292546.1 Gm37173 (from geneSymbol) uc334baa.1 uc334baa.1 
ENSMUST00000292551.1 ENSMUSG00000129274 ENSMUST00000292551.1 ENSMUSG00000129274 (from geneSymbol) uc334baf.1 uc334baf.1 
ENSMUST00000292562.1 ENSMUSG00000129275 ENSMUST00000292562.1 ENSMUSG00000129275 (from geneSymbol) uc334baq.1 uc334baq.1 
ENSMUST00000292563.1 ENSMUSG00000129276 ENSMUST00000292563.1 ENSMUSG00000129276 (from geneSymbol) uc334bar.1 uc334bar.1 
ENSMUST00000292564.1 ENSMUSG00000129277 ENSMUST00000292564.1 ENSMUSG00000129277 (from geneSymbol) uc334bas.1 uc334bas.1 
ENSMUST00000292565.1 ENSMUSG00000129278 ENSMUST00000292565.1 ENSMUSG00000129278 (from geneSymbol) uc334bat.1 uc334bat.1 
ENSMUST00000292567.1 ENSMUSG00000129279 ENSMUST00000292567.1 ENSMUSG00000129279 (from geneSymbol) uc334bav.1 uc334bav.1 
ENSMUST00000292569.1 ENSMUSG00000121510 ENSMUST00000292569.1 ENSMUSG00000121510 (from geneSymbol) AK161769 uc334bax.1 uc334bax.1 
ENSMUST00000292573.1 Gm43057 ENSMUST00000292573.1 Gm43057 (from geneSymbol) uc334bbb.1 uc334bbb.1 
ENSMUST00000292574.1 ENSMUSG00000129280 ENSMUST00000292574.1 ENSMUSG00000129280 (from geneSymbol) uc334bbc.1 uc334bbc.1 
ENSMUST00000292578.1 ENSMUSG00000129281 ENSMUST00000292578.1 ENSMUSG00000129281 (from geneSymbol) uc334bbg.1 uc334bbg.1 
ENSMUST00000292583.1 ENSMUSG00000129282 ENSMUST00000292583.1 ENSMUSG00000129282 (from geneSymbol) uc334bbl.1 uc334bbl.1 
ENSMUST00000292587.1 ENSMUSG00000129283 ENSMUST00000292587.1 ENSMUSG00000129283 (from geneSymbol) uc334bbp.1 uc334bbp.1 
ENSMUST00000292589.1 Gm56829 ENSMUST00000292589.1 Gm56829 (from geneSymbol) AK081879 uc334bbr.1 uc334bbr.1 
ENSMUST00000292656.1 ENSMUSG00000129284 ENSMUST00000292656.1 ENSMUSG00000129284 (from geneSymbol) uc334beg.1 uc334beg.1 
ENSMUST00000292660.1 Gm11592 ENSMUST00000292660.1 Gm11592 (from geneSymbol) AK131683 uc334bek.1 uc334bek.1 
ENSMUST00000292662.1 ENSMUSG00000129285 ENSMUST00000292662.1 ENSMUSG00000129285 (from geneSymbol) uc334bem.1 uc334bem.1 
ENSMUST00000292669.1 ENSMUSG00000129286 ENSMUST00000292669.1 ENSMUSG00000129286 (from geneSymbol) uc334bet.1 uc334bet.1 
ENSMUST00000292671.1 ENSMUSG00000129287 ENSMUST00000292671.1 ENSMUSG00000129287 (from geneSymbol) uc334bev.1 uc334bev.1 
ENSMUST00000292672.1 ENSMUSG00000129288 ENSMUST00000292672.1 ENSMUSG00000129288 (from geneSymbol) uc334bew.1 uc334bew.1 
ENSMUST00000292676.1 ENSMUSG00000129289 ENSMUST00000292676.1 ENSMUSG00000129289 (from geneSymbol) uc334bfa.1 uc334bfa.1 
ENSMUST00000292680.1 ENSMUSG00000129290 ENSMUST00000292680.1 ENSMUSG00000129290 (from geneSymbol) uc334bfd.1 uc334bfd.1 
ENSMUST00000292681.1 ENSMUSG00000129291 ENSMUST00000292681.1 ENSMUSG00000129291 (from geneSymbol) uc334bfe.1 uc334bfe.1 
ENSMUST00000292682.1 ENSMUSG00000129292 ENSMUST00000292682.1 ENSMUSG00000129292 (from geneSymbol) uc334bff.1 uc334bff.1 
ENSMUST00000292683.1 ENSMUSG00000129293 ENSMUST00000292683.1 ENSMUSG00000129293 (from geneSymbol) uc334bfg.1 uc334bfg.1 
ENSMUST00000292684.1 ENSMUSG00000129294 ENSMUST00000292684.1 ENSMUSG00000129294 (from geneSymbol) uc334bfh.1 uc334bfh.1 
ENSMUST00000292685.1 ENSMUSG00000129295 ENSMUST00000292685.1 ENSMUSG00000129295 (from geneSymbol) uc334bfi.1 uc334bfi.1 
ENSMUST00000292688.1 ENSMUSG00000129296 ENSMUST00000292688.1 ENSMUSG00000129296 (from geneSymbol) uc334bfl.1 uc334bfl.1 
ENSMUST00000292690.1 ENSMUSG00000129297 ENSMUST00000292690.1 ENSMUSG00000129297 (from geneSymbol) uc334bfn.1 uc334bfn.1 
ENSMUST00000292692.1 ENSMUSG00000129298 ENSMUST00000292692.1 ENSMUSG00000129298 (from geneSymbol) uc334bfp.1 uc334bfp.1 
ENSMUST00000292701.1 ENSMUSG00000129299 ENSMUST00000292701.1 ENSMUSG00000129299 (from geneSymbol) uc334bfy.1 uc334bfy.1 
ENSMUST00000292702.1 ENSMUSG00000129300 ENSMUST00000292702.1 ENSMUSG00000129300 (from geneSymbol) uc334bfz.1 uc334bfz.1 
ENSMUST00000292703.1 Gm46218 ENSMUST00000292703.1 Gm46218 (from geneSymbol) uc334bga.1 uc334bga.1 
ENSMUST00000292705.1 ENSMUSG00000129301 ENSMUST00000292705.1 ENSMUSG00000129301 (from geneSymbol) uc334bgc.1 uc334bgc.1 
ENSMUST00000292706.1 ENSMUSG00000129302 ENSMUST00000292706.1 ENSMUSG00000129302 (from geneSymbol) uc334bgd.1 uc334bgd.1 
ENSMUST00000292707.1 ENSMUSG00000129303 ENSMUST00000292707.1 ENSMUSG00000129303 (from geneSymbol) uc334bge.1 uc334bge.1 
ENSMUST00000292708.1 ENSMUSG00000129304 ENSMUST00000292708.1 ENSMUSG00000129304 (from geneSymbol) uc334bgf.1 uc334bgf.1 
ENSMUST00000292714.1 ENSMUSG00000129305 ENSMUST00000292714.1 ENSMUSG00000129305 (from geneSymbol) uc334bgl.1 uc334bgl.1 
ENSMUST00000292722.1 4930452G13Rik ENSMUST00000292722.1 4930452G13Rik (from geneSymbol) AK006960 uc334bgt.1 uc334bgt.1 
ENSMUST00000292742.1 ENSMUSG00000129306 ENSMUST00000292742.1 ENSMUSG00000129306 (from geneSymbol) uc334bhn.1 uc334bhn.1 
ENSMUST00000292743.1 ENSMUSG00000129307 ENSMUST00000292743.1 ENSMUSG00000129307 (from geneSymbol) uc334bho.1 uc334bho.1 
ENSMUST00000292744.1 ENSMUSG00000129308 ENSMUST00000292744.1 ENSMUSG00000129308 (from geneSymbol) uc334bhp.1 uc334bhp.1 
ENSMUST00000292745.1 ENSMUSG00000129309 ENSMUST00000292745.1 ENSMUSG00000129309 (from geneSymbol) uc334bhq.1 uc334bhq.1 
ENSMUST00000292746.1 ENSMUSG00000129310 ENSMUST00000292746.1 ENSMUSG00000129310 (from geneSymbol) uc334bhr.1 uc334bhr.1 
ENSMUST00000292748.1 ENSMUSG00000129311 ENSMUST00000292748.1 ENSMUSG00000129311 (from geneSymbol) uc334bht.1 uc334bht.1 
ENSMUST00000292750.1 ENSMUSG00000129312 ENSMUST00000292750.1 ENSMUSG00000129312 (from geneSymbol) AK153385 uc334bhv.1 uc334bhv.1 
ENSMUST00000292751.1 ENSMUSG00000129313 ENSMUST00000292751.1 ENSMUSG00000129313 (from geneSymbol) uc334bhw.1 uc334bhw.1 
ENSMUST00000292776.1 ENSMUSG00000129314 ENSMUST00000292776.1 ENSMUSG00000129314 (from geneSymbol) uc334biv.1 uc334biv.1 
ENSMUST00000292778.1 ENSMUSG00000129315 ENSMUST00000292778.1 ENSMUSG00000129315 (from geneSymbol) LF196908 uc334bix.1 uc334bix.1 
ENSMUST00000292780.1 ENSMUSG00000129317 ENSMUST00000292780.1 ENSMUSG00000129317 (from geneSymbol) uc334biy.1 uc334biy.1 
ENSMUST00000292788.1 ENSMUSG00000129318 ENSMUST00000292788.1 ENSMUSG00000129318 (from geneSymbol) uc334bjg.1 uc334bjg.1 
ENSMUST00000292797.1 Gm36569 ENSMUST00000292797.1 Gm36569 (from geneSymbol) uc334bjp.1 uc334bjp.1 
ENSMUST00000292820.1 Gm47966 ENSMUST00000292820.1 Gm47966 (from geneSymbol) uc334bkm.1 uc334bkm.1 
ENSMUST00000292821.1 ENSMUSG00000129319 ENSMUST00000292821.1 ENSMUSG00000129319 (from geneSymbol) uc334bkn.1 uc334bkn.1 
ENSMUST00000292822.1 ENSMUSG00000129320 ENSMUST00000292822.1 ENSMUSG00000129320 (from geneSymbol) uc334bko.1 uc334bko.1 
ENSMUST00000292829.1 ENSMUSG00000129321 ENSMUST00000292829.1 ENSMUSG00000129321 (from geneSymbol) uc334bkv.1 uc334bkv.1 
ENSMUST00000292832.1 ENSMUSG00000129322 ENSMUST00000292832.1 ENSMUSG00000129322 (from geneSymbol) uc334bky.1 uc334bky.1 
ENSMUST00000292834.1 ENSMUSG00000129323 ENSMUST00000292834.1 ENSMUSG00000129323 (from geneSymbol) uc334bla.1 uc334bla.1 
ENSMUST00000292837.1 ENSMUSG00000129324 ENSMUST00000292837.1 ENSMUSG00000129324 (from geneSymbol) uc334bld.1 uc334bld.1 
ENSMUST00000292838.1 ENSMUSG00000129325 ENSMUST00000292838.1 ENSMUSG00000129325 (from geneSymbol) uc334ble.1 uc334ble.1 
ENSMUST00000292841.1 ENSMUSG00000129326 ENSMUST00000292841.1 ENSMUSG00000129326 (from geneSymbol) uc334blh.1 uc334blh.1 
ENSMUST00000292843.1 Gm57404 ENSMUST00000292843.1 Gm57404 (from geneSymbol) uc334blj.1 uc334blj.1 
ENSMUST00000292844.1 ENSMUSG00000129327 ENSMUST00000292844.1 ENSMUSG00000129327 (from geneSymbol) uc334blk.1 uc334blk.1 
ENSMUST00000292845.1 ENSMUSG00000129328 ENSMUST00000292845.1 ENSMUSG00000129328 (from geneSymbol) uc334bll.1 uc334bll.1 
ENSMUST00000292847.1 ENSMUSG00000129329 ENSMUST00000292847.1 ENSMUSG00000129329 (from geneSymbol) uc334bln.1 uc334bln.1 
ENSMUST00000292850.1 C330011F03Rik ENSMUST00000292850.1 C330011F03Rik (from geneSymbol) AK049176 uc334blq.1 uc334blq.1 
ENSMUST00000292852.1 4930567H12Rik ENSMUST00000292852.1 4930567H12Rik (from geneSymbol) BC048579 uc334bls.1 uc334bls.1 
ENSMUST00000292896.1 ENSMUSG00000129330 ENSMUST00000292896.1 ENSMUSG00000129330 (from geneSymbol) uc334bnk.1 uc334bnk.1 
ENSMUST00000292902.1 Gm56680 ENSMUST00000292902.1 Gm56680 (from geneSymbol) AK017351 uc334bnn.1 uc334bnn.1 
ENSMUST00000292931.1 ENSMUSG00000129331 ENSMUST00000292931.1 ENSMUSG00000129331 (from geneSymbol) uc334boq.1 uc334boq.1 
ENSMUST00000292932.1 ENSMUSG00000129332 ENSMUST00000292932.1 ENSMUSG00000129332 (from geneSymbol) uc334bor.1 uc334bor.1 
ENSMUST00000292936.1 ENSMUSG00000129333 ENSMUST00000292936.1 ENSMUSG00000129333 (from geneSymbol) uc334bov.1 uc334bov.1 
ENSMUST00000292937.1 ENSMUSG00000129334 ENSMUST00000292937.1 ENSMUSG00000129334 (from geneSymbol) uc334bow.1 uc334bow.1 
ENSMUST00000292941.1 ENSMUSG00000129335 ENSMUST00000292941.1 ENSMUSG00000129335 (from geneSymbol) uc334bpa.1 uc334bpa.1 
ENSMUST00000292945.1 ENSMUSG00000129336 ENSMUST00000292945.1 ENSMUSG00000129336 (from geneSymbol) uc334bpe.1 uc334bpe.1 
ENSMUST00000292946.1 ENSMUSG00000129337 ENSMUST00000292946.1 ENSMUSG00000129337 (from geneSymbol) LF198627 uc334bpf.1 uc334bpf.1 
ENSMUST00000292949.1 Gm50103 ENSMUST00000292949.1 Gm50103 (from geneSymbol) uc334bpi.1 uc334bpi.1 
ENSMUST00000292952.1 ENSMUSG00000129338 ENSMUST00000292952.1 ENSMUSG00000129338 (from geneSymbol) uc334bpl.1 uc334bpl.1 
ENSMUST00000292954.1 ENSMUSG00000129339 ENSMUST00000292954.1 ENSMUSG00000129339 (from geneSymbol) uc334bpn.1 uc334bpn.1 
ENSMUST00000292955.1 ENSMUSG00000129340 ENSMUST00000292955.1 ENSMUSG00000129340 (from geneSymbol) uc334bpo.1 uc334bpo.1 
ENSMUST00000292958.1 Gm45155 ENSMUST00000292958.1 Gm45155 (from geneSymbol) uc334bpq.1 uc334bpq.1 
ENSMUST00000292969.1 Gm28271 ENSMUST00000292969.1 Gm28271 (from geneSymbol) AK006875 uc334bqb.1 uc334bqb.1 
ENSMUST00000292985.1 ENSMUSG00000129342 ENSMUST00000292985.1 ENSMUSG00000129342 (from geneSymbol) uc334bqr.1 uc334bqr.1 
ENSMUST00000292986.1 ENSMUSG00000129343 ENSMUST00000292986.1 ENSMUSG00000129343 (from geneSymbol) uc334bqs.1 uc334bqs.1 
ENSMUST00000292997.1 ENSMUSG00000129344 ENSMUST00000292997.1 ENSMUSG00000129344 (from geneSymbol) uc334brd.1 uc334brd.1 
ENSMUST00000293000.1 ENSMUSG00000129345 ENSMUST00000293000.1 ENSMUSG00000129345 (from geneSymbol) uc334brg.1 uc334brg.1 
ENSMUST00000293006.1 1700112D23Rik ENSMUST00000293006.1 1700112D23Rik (from geneSymbol) KY467935 uc334brm.1 uc334brm.1 
ENSMUST00000293019.1 Gm32950 ENSMUST00000293019.1 Gm32950 (from geneSymbol) AK007174 uc334brz.1 uc334brz.1 
ENSMUST00000293038.1 ENSMUSG00000129346 ENSMUST00000293038.1 ENSMUSG00000129346 (from geneSymbol) uc334bss.1 uc334bss.1 
ENSMUST00000293040.1 ENSMUSG00000129347 ENSMUST00000293040.1 ENSMUSG00000129347 (from geneSymbol) uc334bsu.1 uc334bsu.1 
ENSMUST00000293041.1 ENSMUSG00000129348 ENSMUST00000293041.1 ENSMUSG00000129348 (from geneSymbol) uc334bsv.1 uc334bsv.1 
ENSMUST00000293044.1 Gm49470 ENSMUST00000293044.1 Gm49470 (from geneSymbol) uc334bsy.1 uc334bsy.1 
ENSMUST00000293049.1 ENSMUSG00000121678 ENSMUST00000293049.1 ENSMUSG00000121678 (from geneSymbol) AK007258 uc334btd.1 uc334btd.1 
ENSMUST00000293056.1 Gm33024 ENSMUST00000293056.1 Gm33024 (from geneSymbol) uc334btk.1 uc334btk.1 
ENSMUST00000293060.1 ENSMUSG00000129349 ENSMUST00000293060.1 ENSMUSG00000129349 (from geneSymbol) uc334bto.1 uc334bto.1 
ENSMUST00000293061.1 ENSMUSG00000129350 ENSMUST00000293061.1 ENSMUSG00000129350 (from geneSymbol) uc334btp.1 uc334btp.1 
ENSMUST00000293066.1 Gm57257 ENSMUST00000293066.1 Gm57257 (from geneSymbol) uc334btt.1 uc334btt.1 
ENSMUST00000293085.1 ENSMUSG00000129351 ENSMUST00000293085.1 ENSMUSG00000129351 (from geneSymbol) uc334bum.1 uc334bum.1 
ENSMUST00000293087.1 ENSMUSG00000129352 ENSMUST00000293087.1 ENSMUSG00000129352 (from geneSymbol) BC089467 uc334buo.1 uc334buo.1 
ENSMUST00000293088.1 ENSMUSG00000129353 ENSMUST00000293088.1 ENSMUSG00000129353 (from geneSymbol) uc334bup.1 uc334bup.1 
ENSMUST00000293089.1 Gm40797 ENSMUST00000293089.1 Gm40797 (from geneSymbol) uc334buq.1 uc334buq.1 
ENSMUST00000293099.1 ENSMUSG00000129354 ENSMUST00000293099.1 ENSMUSG00000129354 (from geneSymbol) uc334bva.1 uc334bva.1 
ENSMUST00000293114.1 ENSMUSG00000129355 ENSMUST00000293114.1 ENSMUSG00000129355 (from geneSymbol) uc334bvp.1 uc334bvp.1 
ENSMUST00000293116.1 ENSMUSG00000129356 ENSMUST00000293116.1 ENSMUSG00000129356 (from geneSymbol) uc334bvr.1 uc334bvr.1 
ENSMUST00000293119.1 Gm11583 ENSMUST00000293119.1 Gm11583 (from geneSymbol) uc334bvu.1 uc334bvu.1 
ENSMUST00000293120.1 A630050E04Rik ENSMUST00000293120.1 A630050E04Rik (from geneSymbol) AK041976 uc334bvv.1 uc334bvv.1 
ENSMUST00000293121.1 ENSMUSG00000129357 ENSMUST00000293121.1 ENSMUSG00000129357 (from geneSymbol) uc334bvw.1 uc334bvw.1 
ENSMUST00000293122.1 ENSMUSG00000129358 ENSMUST00000293122.1 ENSMUSG00000129358 (from geneSymbol) uc334bvx.1 uc334bvx.1 
ENSMUST00000293128.1 Gm12505 ENSMUST00000293128.1 Gm12505 (from geneSymbol) BC049732 uc334bwd.1 uc334bwd.1 
ENSMUST00000293138.1 ENSMUSG00000129359 ENSMUST00000293138.1 ENSMUSG00000129359 (from geneSymbol) uc334bwn.1 uc334bwn.1 
ENSMUST00000293139.1 ENSMUSG00000129360 ENSMUST00000293139.1 ENSMUSG00000129360 (from geneSymbol) uc334bwo.1 uc334bwo.1 
ENSMUST00000293141.1 ENSMUSG00000129361 ENSMUST00000293141.1 ENSMUSG00000129361 (from geneSymbol) uc334bwq.1 uc334bwq.1 
ENSMUST00000293143.1 ENSMUSG00000129362 ENSMUST00000293143.1 ENSMUSG00000129362 (from geneSymbol) uc334bws.1 uc334bws.1 
ENSMUST00000293147.1 ENSMUSG00000129363 ENSMUST00000293147.1 ENSMUSG00000129363 (from geneSymbol) uc334bww.1 uc334bww.1 
ENSMUST00000293148.1 ENSMUSG00000129364 ENSMUST00000293148.1 ENSMUSG00000129364 (from geneSymbol) uc334bwx.1 uc334bwx.1 
ENSMUST00000293152.1 ENSMUSG00000129365 ENSMUST00000293152.1 ENSMUSG00000129365 (from geneSymbol) uc334bxb.1 uc334bxb.1 
ENSMUST00000293153.1 ENSMUSG00000129366 ENSMUST00000293153.1 ENSMUSG00000129366 (from geneSymbol) uc334bxc.1 uc334bxc.1 
ENSMUST00000293154.1 Gm26684 ENSMUST00000293154.1 Gm26684 (from geneSymbol) AK142516 uc334bxd.1 uc334bxd.1 
ENSMUST00000293188.1 ENSMUSG00000129367 ENSMUST00000293188.1 ENSMUSG00000129367 (from geneSymbol) uc334byl.1 uc334byl.1 
ENSMUST00000293189.1 ENSMUSG00000129368 ENSMUST00000293189.1 ENSMUSG00000129368 (from geneSymbol) uc334bym.1 uc334bym.1 
ENSMUST00000293191.1 ENSMUSG00000129369 ENSMUST00000293191.1 ENSMUSG00000129369 (from geneSymbol) uc334byo.1 uc334byo.1 
ENSMUST00000293192.1 ENSMUSG00000129370 ENSMUST00000293192.1 ENSMUSG00000129370 (from geneSymbol) uc334byp.1 uc334byp.1 
ENSMUST00000293194.1 Gm40621 ENSMUST00000293194.1 Gm40621 (from geneSymbol) uc334byr.1 uc334byr.1 
ENSMUST00000293204.1 ENSMUSG00000129371 ENSMUST00000293204.1 ENSMUSG00000129371 (from geneSymbol) uc334bzb.1 uc334bzb.1 
ENSMUST00000293205.1 ENSMUSG00000129372 ENSMUST00000293205.1 ENSMUSG00000129372 (from geneSymbol) uc334bzc.1 uc334bzc.1 
ENSMUST00000293209.1 ENSMUSG00000129373 ENSMUST00000293209.1 ENSMUSG00000129373 (from geneSymbol) uc334bzg.1 uc334bzg.1 
ENSMUST00000293229.1 4930471G03Rik ENSMUST00000293229.1 4930471G03Rik (from geneSymbol) BC100467 uc334bzk.1 uc334bzk.1 
ENSMUST00000293235.1 ENSMUSG00000129375 ENSMUST00000293235.1 ENSMUSG00000129375 (from geneSymbol) AK078619 uc334bzq.1 uc334bzq.1 
ENSMUST00000293236.1 Gm56885 ENSMUST00000293236.1 Gm56885 (from geneSymbol) uc334bzr.1 uc334bzr.1 
ENSMUST00000293238.1 ENSMUSG00000129376 ENSMUST00000293238.1 ENSMUSG00000129376 (from geneSymbol) uc334bzt.1 uc334bzt.1 
ENSMUST00000293240.1 ENSMUSG00000129377 ENSMUST00000293240.1 ENSMUSG00000129377 (from geneSymbol) DQ542112 uc334bzv.1 uc334bzv.1 
ENSMUST00000293241.1 Gm36041 ENSMUST00000293241.1 Gm36041 (from geneSymbol) uc334bzw.1 uc334bzw.1 
ENSMUST00000293341.1 ENSMUSG00000129378 ENSMUST00000293341.1 ENSMUSG00000129378 (from geneSymbol) uc334cds.1 uc334cds.1 
ENSMUST00000293343.1 ENSMUSG00000129379 ENSMUST00000293343.1 ENSMUSG00000129379 (from geneSymbol) uc334cdu.1 uc334cdu.1 
ENSMUST00000293345.1 Gm44169 ENSMUST00000293345.1 Gm44169 (from geneSymbol) uc334cdw.1 uc334cdw.1 
ENSMUST00000293366.1 ENSMUSG00000129380 ENSMUST00000293366.1 ENSMUSG00000129380 (from geneSymbol) uc334cer.1 uc334cer.1 
ENSMUST00000293367.1 ENSMUSG00000129381 ENSMUST00000293367.1 ENSMUSG00000129381 (from geneSymbol) uc334ces.1 uc334ces.1 
ENSMUST00000293368.1 ENSMUSG00000129382 ENSMUST00000293368.1 ENSMUSG00000129382 (from geneSymbol) uc334cet.1 uc334cet.1 
ENSMUST00000293369.1 ENSMUSG00000129383 ENSMUST00000293369.1 ENSMUSG00000129383 (from geneSymbol) uc334ceu.1 uc334ceu.1 
ENSMUST00000293371.1 ENSMUSG00000129384 ENSMUST00000293371.1 ENSMUSG00000129384 (from geneSymbol) uc334cew.1 uc334cew.1 
ENSMUST00000293372.1 ENSMUSG00000129385 ENSMUST00000293372.1 ENSMUSG00000129385 (from geneSymbol) uc334cex.1 uc334cex.1 
ENSMUST00000293379.1 Gm15734 ENSMUST00000293379.1 Gm15734 (from geneSymbol) uc334cfe.1 uc334cfe.1 
ENSMUST00000293381.1 ENSMUSG00000129386 ENSMUST00000293381.1 ENSMUSG00000129386 (from geneSymbol) uc334cfg.1 uc334cfg.1 
ENSMUST00000293384.1 ENSMUSG00000129387 ENSMUST00000293384.1 ENSMUSG00000129387 (from geneSymbol) uc334cfj.1 uc334cfj.1 
ENSMUST00000293390.1 ENSMUSG00000129388 ENSMUST00000293390.1 ENSMUSG00000129388 (from geneSymbol) uc334cfp.1 uc334cfp.1 
ENSMUST00000293399.1 ENSMUSG00000129389 ENSMUST00000293399.1 ENSMUSG00000129389 (from geneSymbol) uc334cfy.1 uc334cfy.1 
ENSMUST00000293401.1 ENSMUSG00000129390 ENSMUST00000293401.1 ENSMUSG00000129390 (from geneSymbol) uc334cga.1 uc334cga.1 
ENSMUST00000293402.1 ENSMUSG00000129391 ENSMUST00000293402.1 ENSMUSG00000129391 (from geneSymbol) uc334cgb.1 uc334cgb.1 
ENSMUST00000293405.1 4930458B22Rik ENSMUST00000293405.1 4930458B22Rik (from geneSymbol) AK016243 uc334cge.1 uc334cge.1 
ENSMUST00000293418.1 Gm28640 ENSMUST00000293418.1 Gm28640 (from geneSymbol) uc334cgr.1 uc334cgr.1 
ENSMUST00000293419.1 ENSMUSG00000129392 ENSMUST00000293419.1 ENSMUSG00000129392 (from geneSymbol) uc334cgs.1 uc334cgs.1 
ENSMUST00000293420.1 ENSMUSG00000129393 ENSMUST00000293420.1 ENSMUSG00000129393 (from geneSymbol) uc334cgt.1 uc334cgt.1 
ENSMUST00000293421.1 Dnah2os ENSMUST00000293421.1 Dnah2os (from geneSymbol) AK020071 uc334cgu.1 uc334cgu.1 
ENSMUST00000293424.1 ENSMUSG00000129394 ENSMUST00000293424.1 ENSMUSG00000129394 (from geneSymbol) uc334cgx.1 uc334cgx.1 
ENSMUST00000293425.1 ENSMUSG00000129395 ENSMUST00000293425.1 ENSMUSG00000129395 (from geneSymbol) uc334cgy.1 uc334cgy.1 
ENSMUST00000293426.1 ENSMUSG00000129396 ENSMUST00000293426.1 ENSMUSG00000129396 (from geneSymbol) uc334cgz.1 uc334cgz.1 
ENSMUST00000293428.1 ENSMUSG00000129397 ENSMUST00000293428.1 ENSMUSG00000129397 (from geneSymbol) uc334chb.1 uc334chb.1 
ENSMUST00000293430.1 ENSMUSG00000129398 ENSMUST00000293430.1 ENSMUSG00000129398 (from geneSymbol) uc334chd.1 uc334chd.1 
ENSMUST00000293431.1 ENSMUSG00000129399 ENSMUST00000293431.1 ENSMUSG00000129399 (from geneSymbol) uc334che.1 uc334che.1 
ENSMUST00000293434.1 Gm17227 ENSMUST00000293434.1 Gm17227 (from geneSymbol) AK076927 uc334chh.1 uc334chh.1 
ENSMUST00000293437.1 ENSMUSG00000129400 ENSMUST00000293437.1 ENSMUSG00000129400 (from geneSymbol) uc334chj.1 uc334chj.1 
ENSMUST00000293438.1 ENSMUSG00000129401 ENSMUST00000293438.1 ENSMUSG00000129401 (from geneSymbol) uc334chk.1 uc334chk.1 
ENSMUST00000293439.1 ENSMUSG00000129402 ENSMUST00000293439.1 ENSMUSG00000129402 (from geneSymbol) uc334chl.1 uc334chl.1 
ENSMUST00000293442.1 ENSMUSG00000129403 ENSMUST00000293442.1 ENSMUSG00000129403 (from geneSymbol) uc334cho.1 uc334cho.1 
ENSMUST00000293443.1 ENSMUSG00000129404 ENSMUST00000293443.1 ENSMUSG00000129404 (from geneSymbol) uc334chp.1 uc334chp.1 
ENSMUST00000293446.1 ENSMUSG00000129405 ENSMUST00000293446.1 ENSMUSG00000129405 (from geneSymbol) uc334chs.1 uc334chs.1 
ENSMUST00000293448.1 ENSMUSG00000129406 ENSMUST00000293448.1 ENSMUSG00000129406 (from geneSymbol) uc334chu.1 uc334chu.1 
ENSMUST00000293449.1 ENSMUSG00000129407 ENSMUST00000293449.1 ENSMUSG00000129407 (from geneSymbol) uc334chv.1 uc334chv.1 
ENSMUST00000293455.1 ENSMUSG00000129408 ENSMUST00000293455.1 ENSMUSG00000129408 (from geneSymbol) uc334cib.1 uc334cib.1 
ENSMUST00000293457.1 E230029C05Rik ENSMUST00000293457.1 E230029C05Rik (from geneSymbol) AK157435 uc334cic.1 uc334cic.1 
ENSMUST00000293573.1 ENSMUSG00000129409 ENSMUST00000293573.1 ENSMUSG00000129409 (from geneSymbol) uc334cmn.1 uc334cmn.1 
ENSMUST00000293575.1 ENSMUSG00000129410 ENSMUST00000293575.1 ENSMUSG00000129410 (from geneSymbol) uc334cmp.1 uc334cmp.1 
ENSMUST00000293579.1 ENSMUSG00000129411 ENSMUST00000293579.1 ENSMUSG00000129411 (from geneSymbol) uc334cmt.1 uc334cmt.1 
ENSMUST00000293583.1 ENSMUSG00000129412 ENSMUST00000293583.1 ENSMUSG00000129412 (from geneSymbol) uc334cmx.1 uc334cmx.1 
ENSMUST00000293596.1 ENSMUSG00000129414 ENSMUST00000293596.1 ENSMUSG00000129414 (from geneSymbol) uc334cnh.1 uc334cnh.1 
ENSMUST00000293600.1 1700028P15Rik ENSMUST00000293600.1 1700028P15Rik (from geneSymbol) uc334cnl.1 uc334cnl.1 
ENSMUST00000293635.1 ENSMUSG00000129415 ENSMUST00000293635.1 ENSMUSG00000129415 (from geneSymbol) uc334cou.1 uc334cou.1 
ENSMUST00000293636.1 ENSMUSG00000129416 ENSMUST00000293636.1 ENSMUSG00000129416 (from geneSymbol) uc334cov.1 uc334cov.1 
ENSMUST00000293637.1 ENSMUSG00000129417 ENSMUST00000293637.1 ENSMUSG00000129417 (from geneSymbol) uc334cow.1 uc334cow.1 
ENSMUST00000293639.1 ENSMUSG00000129418 ENSMUST00000293639.1 ENSMUSG00000129418 (from geneSymbol) uc334cox.1 uc334cox.1 
ENSMUST00000293641.1 ENSMUSG00000129419 ENSMUST00000293641.1 ENSMUSG00000129419 (from geneSymbol) uc334coz.1 uc334coz.1 
ENSMUST00000293644.1 ENSMUSG00000129420 ENSMUST00000293644.1 ENSMUSG00000129420 (from geneSymbol) uc334cpc.1 uc334cpc.1 
ENSMUST00000293648.1 ENSMUSG00000129421 ENSMUST00000293648.1 ENSMUSG00000129421 (from geneSymbol) uc334cpg.1 uc334cpg.1 
ENSMUST00000293650.1 ENSMUSG00000129422 ENSMUST00000293650.1 ENSMUSG00000129422 (from geneSymbol) uc334cpi.1 uc334cpi.1 
ENSMUST00000293653.1 ENSMUSG00000129423 ENSMUST00000293653.1 ENSMUSG00000129423 (from geneSymbol) AK007183 uc334cpl.1 uc334cpl.1 
ENSMUST00000293654.1 ENSMUSG00000129424 ENSMUST00000293654.1 ENSMUSG00000129424 (from geneSymbol) uc334cpm.1 uc334cpm.1 
ENSMUST00000293656.1 ENSMUSG00000129425 ENSMUST00000293656.1 ENSMUSG00000129425 (from geneSymbol) uc334cpo.1 uc334cpo.1 
ENSMUST00000293657.1 ENSMUSG00000129426 ENSMUST00000293657.1 ENSMUSG00000129426 (from geneSymbol) uc334cpp.1 uc334cpp.1 
ENSMUST00000293669.1 ENSMUSG00000129427 ENSMUST00000293669.1 ENSMUSG00000129427 (from geneSymbol) uc334cqb.1 uc334cqb.1 
ENSMUST00000293680.1 ENSMUSG00000129428 ENSMUST00000293680.1 ENSMUSG00000129428 (from geneSymbol) uc334cqm.1 uc334cqm.1 
ENSMUST00000293682.1 ENSMUSG00000129429 ENSMUST00000293682.1 ENSMUSG00000129429 (from geneSymbol) uc334cqo.1 uc334cqo.1 
ENSMUST00000293683.1 ENSMUSG00000129430 ENSMUST00000293683.1 ENSMUSG00000129430 (from geneSymbol) uc334cqp.1 uc334cqp.1 
ENSMUST00000293684.1 ENSMUSG00000129431 ENSMUST00000293684.1 ENSMUSG00000129431 (from geneSymbol) uc334cqq.1 uc334cqq.1 
ENSMUST00000293694.1 ENSMUSG00000129432 ENSMUST00000293694.1 ENSMUSG00000129432 (from geneSymbol) uc334cra.1 uc334cra.1 
ENSMUST00000293695.1 ENSMUSG00000129433 ENSMUST00000293695.1 ENSMUSG00000129433 (from geneSymbol) uc334crb.1 uc334crb.1 
ENSMUST00000293697.1 ENSMUSG00000129434 ENSMUST00000293697.1 ENSMUSG00000129434 (from geneSymbol) uc334crd.1 uc334crd.1 
ENSMUST00000293700.1 ENSMUSG00000129435 ENSMUST00000293700.1 ENSMUSG00000129435 (from geneSymbol) uc334crg.1 uc334crg.1 
ENSMUST00000293705.1 Gm31456 ENSMUST00000293705.1 Gm31456 (from geneSymbol) AK133121 uc334crl.1 uc334crl.1 
ENSMUST00000293744.1 ENSMUSG00000129436 ENSMUST00000293744.1 ENSMUSG00000129436 (from geneSymbol) uc334csy.1 uc334csy.1 
ENSMUST00000293749.1 Gm33674 ENSMUST00000293749.1 Gm33674 (from geneSymbol) uc334ctd.1 uc334ctd.1 
ENSMUST00000293768.1 Gm9925 ENSMUST00000293768.1 Gm9925 (from geneSymbol) AK036329 uc334ctw.1 uc334ctw.1 
ENSMUST00000293775.1 ENSMUSG00000129438 ENSMUST00000293775.1 ENSMUSG00000129438 (from geneSymbol) uc334cud.1 uc334cud.1 
ENSMUST00000293776.1 ENSMUSG00000129439 ENSMUST00000293776.1 ENSMUSG00000129439 (from geneSymbol) uc334cue.1 uc334cue.1 
ENSMUST00000293777.1 ENSMUSG00000129440 ENSMUST00000293777.1 ENSMUSG00000129440 (from geneSymbol) uc334cuf.1 uc334cuf.1 
ENSMUST00000293779.1 ENSMUSG00000129441 ENSMUST00000293779.1 ENSMUSG00000129441 (from geneSymbol) uc334cuh.1 uc334cuh.1 
ENSMUST00000293781.1 ENSMUSG00000129442 ENSMUST00000293781.1 ENSMUSG00000129442 (from geneSymbol) uc334cuj.1 uc334cuj.1 
ENSMUST00000293782.1 ENSMUSG00000129443 ENSMUST00000293782.1 ENSMUSG00000129443 (from geneSymbol) uc334cuk.1 uc334cuk.1 
ENSMUST00000293788.1 Gm3294 ENSMUST00000293788.1 Gm3294 (from geneSymbol) uc334cuq.1 uc334cuq.1 
ENSMUST00000293806.1 ENSMUSG00000129444 ENSMUST00000293806.1 ENSMUSG00000129444 (from geneSymbol) uc334cvi.1 uc334cvi.1 
ENSMUST00000293809.1 ENSMUSG00000129445 ENSMUST00000293809.1 ENSMUSG00000129445 (from geneSymbol) uc334cvl.1 uc334cvl.1 
ENSMUST00000293832.1 ENSMUSG00000129446 ENSMUST00000293832.1 ENSMUSG00000129446 (from geneSymbol) uc334cwe.1 uc334cwe.1 
ENSMUST00000293834.1 Gm34510 ENSMUST00000293834.1 Gm34510 (from geneSymbol) uc334cwf.1 uc334cwf.1 
ENSMUST00000293841.1 ENSMUSG00000129447 ENSMUST00000293841.1 ENSMUSG00000129447 (from geneSymbol) uc334cwm.1 uc334cwm.1 
ENSMUST00000293842.1 ENSMUSG00000129448 ENSMUST00000293842.1 ENSMUSG00000129448 (from geneSymbol) uc334cwn.1 uc334cwn.1 
ENSMUST00000293843.1 ENSMUSG00000129449 ENSMUST00000293843.1 ENSMUSG00000129449 (from geneSymbol) DL243180 uc334cwo.1 uc334cwo.1 
ENSMUST00000293846.1 ENSMUSG00000129450 ENSMUST00000293846.1 ENSMUSG00000129450 (from geneSymbol) uc334cwr.1 uc334cwr.1 
ENSMUST00000293847.1 Gm1600 ENSMUST00000293847.1 Gm1600 (from geneSymbol) AK028773 uc334cws.1 uc334cws.1 
ENSMUST00000293858.1 ENSMUSG00000129451 ENSMUST00000293858.1 ENSMUSG00000129451 (from geneSymbol) uc334cxd.1 uc334cxd.1 
ENSMUST00000293862.1 Lncbate3 ENSMUST00000293862.1 Lncbate3 (from geneSymbol) AK005635 uc334cxh.1 uc334cxh.1 
ENSMUST00000293874.1 Gm14396 ENSMUST00000293874.1 Gm14396 (from geneSymbol) BC060302 uc334cxt.1 uc334cxt.1 
ENSMUST00000293879.1 ENSMUSG00000129452 ENSMUST00000293879.1 ENSMUSG00000129452 (from geneSymbol) uc334cxy.1 uc334cxy.1 
ENSMUST00000293883.1 ENSMUSG00000129453 ENSMUST00000293883.1 ENSMUSG00000129453 (from geneSymbol) uc334cyc.1 uc334cyc.1 
ENSMUST00000293910.1 ENSMUSG00000129454 ENSMUST00000293910.1 ENSMUSG00000129454 (from geneSymbol) uc334czd.1 uc334czd.1 
ENSMUST00000293916.1 4930506A18Rik ENSMUST00000293916.1 RIKEN cDNA 4930506A18 gene, transcript variant 1 (from RefSeq NR_126090.2) NR_126090 uc334czj.1 uc334czj.1 
ENSMUST00000293920.1 ENSMUSG00000129456 ENSMUST00000293920.1 ENSMUSG00000129456 (from geneSymbol) uc334czn.1 uc334czn.1 
ENSMUST00000293926.1 ENSMUSG00000129457 ENSMUST00000293926.1 ENSMUSG00000129457 (from geneSymbol) uc334czt.1 uc334czt.1 
ENSMUST00000293927.1 Gm15564 ENSMUST00000293927.1 Gm15564 (from geneSymbol) AK144265 uc334czu.1 uc334czu.1 
ENSMUST00000293935.1 Gm32164 ENSMUST00000293935.1 Gm32164 (from geneSymbol) uc334dac.1 uc334dac.1 
ENSMUST00000293951.1 ENSMUSG00000129458 ENSMUST00000293951.1 ENSMUSG00000129458 (from geneSymbol) uc334daq.1 uc334daq.1 
ENSMUST00000293952.1 ENSMUSG00000129459 ENSMUST00000293952.1 ENSMUSG00000129459 (from geneSymbol) uc334dar.1 uc334dar.1 
ENSMUST00000293956.1 ENSMUSG00000129460 ENSMUST00000293956.1 ENSMUSG00000129460 (from geneSymbol) uc334dav.1 uc334dav.1 
ENSMUST00000293957.1 ENSMUSG00000129461 ENSMUST00000293957.1 ENSMUSG00000129461 (from geneSymbol) uc334daw.1 uc334daw.1 
ENSMUST00000293958.1 ENSMUSG00000129462 ENSMUST00000293958.1 ENSMUSG00000129462 (from geneSymbol) uc334dax.1 uc334dax.1 
ENSMUST00000293959.1 Gm56965 ENSMUST00000293959.1 Gm56965 (from geneSymbol) uc334day.1 uc334day.1 
ENSMUST00000293962.1 ENSMUSG00000129463 ENSMUST00000293962.1 ENSMUSG00000129463 (from geneSymbol) uc334dbb.1 uc334dbb.1 
ENSMUST00000293963.1 Gm47914 ENSMUST00000293963.1 Gm47914 (from geneSymbol) uc334dbc.1 uc334dbc.1 
ENSMUST00000293964.1 ENSMUSG00000129464 ENSMUST00000293964.1 ENSMUSG00000129464 (from geneSymbol) uc334dbd.1 uc334dbd.1 
ENSMUST00000293965.1 ENSMUSG00000129465 ENSMUST00000293965.1 ENSMUSG00000129465 (from geneSymbol) uc334dbe.1 uc334dbe.1 
ENSMUST00000293970.1 Gm32884 ENSMUST00000293970.1 Gm32884 (from geneSymbol) KY468166 uc334dbj.1 uc334dbj.1 
ENSMUST00000293973.1 ENSMUSG00000129466 ENSMUST00000293973.1 ENSMUSG00000129466 (from geneSymbol) uc334dbm.1 uc334dbm.1 
ENSMUST00000293974.1 ENSMUSG00000129467 ENSMUST00000293974.1 ENSMUSG00000129467 (from geneSymbol) uc334dbn.1 uc334dbn.1 
ENSMUST00000293976.1 ENSMUSG00000129468 ENSMUST00000293976.1 ENSMUSG00000129468 (from geneSymbol) uc334dbp.1 uc334dbp.1 
ENSMUST00000293977.1 ENSMUSG00000129469 ENSMUST00000293977.1 ENSMUSG00000129469 (from geneSymbol) uc334dbq.1 uc334dbq.1 
ENSMUST00000293978.1 5031434O11Rik ENSMUST00000293978.1 5031434O11Rik (from geneSymbol) AK048747 uc334dbr.1 uc334dbr.1 
ENSMUST00000293994.1 ENSMUSG00000129470 ENSMUST00000293994.1 ENSMUSG00000129470 (from geneSymbol) uc334dch.1 uc334dch.1 
ENSMUST00000293999.1 ENSMUSG00000129471 ENSMUST00000293999.1 ENSMUSG00000129471 (from geneSymbol) uc334dcm.1 uc334dcm.1 
ENSMUST00000294000.1 Gm26902 ENSMUST00000294000.1 Gm26902 (from geneSymbol) AK142879 uc334dcn.1 uc334dcn.1 
ENSMUST00000294004.1 ENSMUSG00000129472 ENSMUST00000294004.1 ENSMUSG00000129472 (from geneSymbol) uc334dcr.1 uc334dcr.1 
ENSMUST00000294005.1 ENSMUSG00000129473 ENSMUST00000294005.1 ENSMUSG00000129473 (from geneSymbol) uc334dcs.1 uc334dcs.1 
ENSMUST00000294007.1 ENSMUSG00000129474 ENSMUST00000294007.1 ENSMUSG00000129474 (from geneSymbol) uc334dcu.1 uc334dcu.1 
ENSMUST00000294011.1 Gm35025 ENSMUST00000294011.1 Gm35025 (from geneSymbol) uc334dcy.1 uc334dcy.1 
ENSMUST00000294026.1 ENSMUSG00000129475 ENSMUST00000294026.1 ENSMUSG00000129475 (from geneSymbol) uc334ddn.1 uc334ddn.1 
ENSMUST00000294029.1 ENSMUSG00000129477 ENSMUST00000294029.1 ENSMUSG00000129477 (from geneSymbol) uc334ddp.1 uc334ddp.1 
ENSMUST00000294030.1 ENSMUSG00000129478 ENSMUST00000294030.1 ENSMUSG00000129478 (from geneSymbol) uc334ddq.1 uc334ddq.1 
ENSMUST00000294044.1 ENSMUSG00000129479 ENSMUST00000294044.1 ENSMUSG00000129479 (from geneSymbol) uc334dee.1 uc334dee.1 
ENSMUST00000294045.1 ENSMUSG00000129480 ENSMUST00000294045.1 ENSMUSG00000129480 (from geneSymbol) uc334def.1 uc334def.1 
ENSMUST00000294046.1 ENSMUSG00000129481 ENSMUST00000294046.1 ENSMUSG00000129481 (from geneSymbol) uc334deg.1 uc334deg.1 
ENSMUST00000294056.1 ENSMUSG00000129483 ENSMUST00000294056.1 ENSMUSG00000129483 (from geneSymbol) uc334deo.1 uc334deo.1 
ENSMUST00000294062.1 ENSMUSG00000129484 ENSMUST00000294062.1 ENSMUSG00000129484 (from geneSymbol) uc334deu.1 uc334deu.1 
ENSMUST00000294065.1 ENSMUSG00000129485 ENSMUST00000294065.1 ENSMUSG00000129485 (from geneSymbol) uc334dex.1 uc334dex.1 
ENSMUST00000294073.1 ENSMUSG00000129486 ENSMUST00000294073.1 ENSMUSG00000129486 (from geneSymbol) uc334dff.1 uc334dff.1 
ENSMUST00000294074.1 Gm10635 ENSMUST00000294074.1 Gm10635 (from geneSymbol) AK142702 uc334dfg.1 uc334dfg.1 
ENSMUST00000294079.1 ENSMUSG00000129487 ENSMUST00000294079.1 ENSMUSG00000129487 (from geneSymbol) uc334dfl.1 uc334dfl.1 
ENSMUST00000294081.1 ENSMUSG00000129488 ENSMUST00000294081.1 ENSMUSG00000129488 (from geneSymbol) uc334dfn.1 uc334dfn.1 
ENSMUST00000294083.1 ENSMUSG00000129489 ENSMUST00000294083.1 ENSMUSG00000129489 (from geneSymbol) uc334dfp.1 uc334dfp.1 
ENSMUST00000294085.1 ENSMUSG00000129490 ENSMUST00000294085.1 ENSMUSG00000129490 (from geneSymbol) uc334dfr.1 uc334dfr.1 
ENSMUST00000294089.1 ENSMUSG00000129491 ENSMUST00000294089.1 ENSMUSG00000129491 (from geneSymbol) uc334dfv.1 uc334dfv.1 
ENSMUST00000294092.1 ENSMUSG00000129492 ENSMUST00000294092.1 ENSMUSG00000129492 (from geneSymbol) uc334dfy.1 uc334dfy.1 
ENSMUST00000294094.1 ENSMUSG00000129493 ENSMUST00000294094.1 ENSMUSG00000129493 (from geneSymbol) uc334dga.1 uc334dga.1 
ENSMUST00000294096.1 ENSMUSG00000129494 ENSMUST00000294096.1 ENSMUSG00000129494 (from geneSymbol) uc334dgc.1 uc334dgc.1 
ENSMUST00000294097.1 ENSMUSG00000129495 ENSMUST00000294097.1 ENSMUSG00000129495 (from geneSymbol) uc334dgd.1 uc334dgd.1 
ENSMUST00000294098.1 ENSMUSG00000129496 ENSMUST00000294098.1 ENSMUSG00000129496 (from geneSymbol) uc334dge.1 uc334dge.1 
ENSMUST00000294099.1 ENSMUSG00000129497 ENSMUST00000294099.1 ENSMUSG00000129497 (from geneSymbol) uc334dgf.1 uc334dgf.1 
ENSMUST00000294101.1 ENSMUSG00000129498 ENSMUST00000294101.1 ENSMUSG00000129498 (from geneSymbol) uc334dgh.1 uc334dgh.1 
ENSMUST00000294103.1 ENSMUSG00000129499 ENSMUST00000294103.1 ENSMUSG00000129499 (from geneSymbol) uc334dgj.1 uc334dgj.1 
ENSMUST00000294113.1 2310010J17Rik ENSMUST00000294113.1 2310010J17Rik (from geneSymbol) BC048663 uc334dgt.1 uc334dgt.1 
ENSMUST00000294128.1 Gm32718 ENSMUST00000294128.1 Gm32718 (from geneSymbol) uc334dhi.1 uc334dhi.1 
ENSMUST00000294136.1 ENSMUSG00000129500 ENSMUST00000294136.1 ENSMUSG00000129500 (from geneSymbol) uc334dhq.1 uc334dhq.1 
ENSMUST00000294137.1 ENSMUSG00000129501 ENSMUST00000294137.1 ENSMUSG00000129501 (from geneSymbol) uc334dhr.1 uc334dhr.1 
ENSMUST00000294138.1 ENSMUSG00000129502 ENSMUST00000294138.1 ENSMUSG00000129502 (from geneSymbol) uc334dhs.1 uc334dhs.1 
ENSMUST00000294143.1 ENSMUSG00000129503 ENSMUST00000294143.1 ENSMUSG00000129503 (from geneSymbol) uc334dhx.1 uc334dhx.1 
ENSMUST00000294144.1 1700128A07Rik ENSMUST00000294144.1 1700128A07Rik (from geneSymbol) AK007305 uc334dhy.1 uc334dhy.1 
ENSMUST00000294190.1 A230070E04Rik ENSMUST00000294190.1 A230070E04Rik (from geneSymbol) AK164995 uc334djs.1 uc334djs.1 
ENSMUST00000294202.1 ENSMUSG00000129505 ENSMUST00000294202.1 ENSMUSG00000129505 (from geneSymbol) uc334dke.1 uc334dke.1 
ENSMUST00000294203.1 ENSMUSG00000129506 ENSMUST00000294203.1 ENSMUSG00000129506 (from geneSymbol) uc334dkf.1 uc334dkf.1 
ENSMUST00000294204.1 ENSMUSG00000129507 ENSMUST00000294204.1 ENSMUSG00000129507 (from geneSymbol) uc334dkg.1 uc334dkg.1 
ENSMUST00000294205.1 ENSMUSG00000129508 ENSMUST00000294205.1 ENSMUSG00000129508 (from geneSymbol) uc334dkh.1 uc334dkh.1 
ENSMUST00000294210.1 ENSMUSG00000129509 ENSMUST00000294210.1 ENSMUSG00000129509 (from geneSymbol) uc334dkm.1 uc334dkm.1 
ENSMUST00000294218.1 ENSMUSG00000129510 ENSMUST00000294218.1 ENSMUSG00000129510 (from geneSymbol) uc334dku.1 uc334dku.1 
ENSMUST00000294222.1 ENSMUSG00000129512 ENSMUST00000294222.1 ENSMUSG00000129512 (from geneSymbol) uc334dkw.1 uc334dkw.1 
ENSMUST00000294223.1 ENSMUSG00000129513 ENSMUST00000294223.1 ENSMUSG00000129513 (from geneSymbol) uc334dkx.1 uc334dkx.1 
ENSMUST00000294224.1 ENSMUSG00000129514 ENSMUST00000294224.1 ENSMUSG00000129514 (from geneSymbol) uc334dky.1 uc334dky.1 
ENSMUST00000294225.1 ENSMUSG00000129515 ENSMUST00000294225.1 ENSMUSG00000129515 (from geneSymbol) uc334dkz.1 uc334dkz.1 
ENSMUST00000294227.1 ENSMUSG00000129516 ENSMUST00000294227.1 ENSMUSG00000129516 (from geneSymbol) uc334dlb.1 uc334dlb.1 
ENSMUST00000294230.1 ENSMUSG00000129517 ENSMUST00000294230.1 ENSMUSG00000129517 (from geneSymbol) uc334dle.1 uc334dle.1 
ENSMUST00000294233.1 Gm43134 ENSMUST00000294233.1 Gm43134 (from geneSymbol) uc334dlh.1 uc334dlh.1 
ENSMUST00000294235.1 ENSMUSG00000129518 ENSMUST00000294235.1 ENSMUSG00000129518 (from geneSymbol) uc334dlj.1 uc334dlj.1 
ENSMUST00000294236.1 ENSMUSG00000129519 ENSMUST00000294236.1 ENSMUSG00000129519 (from geneSymbol) uc334dlk.1 uc334dlk.1 
ENSMUST00000294237.1 ENSMUSG00000129520 ENSMUST00000294237.1 ENSMUSG00000129520 (from geneSymbol) uc334dll.1 uc334dll.1 
ENSMUST00000294245.1 ENSMUSG00000129521 ENSMUST00000294245.1 ENSMUSG00000129521 (from geneSymbol) uc334dlt.1 uc334dlt.1 
ENSMUST00000294249.1 ENSMUSG00000129522 ENSMUST00000294249.1 ENSMUSG00000129522 (from geneSymbol) uc334dlx.1 uc334dlx.1 
ENSMUST00000294256.1 ENSMUSG00000129523 ENSMUST00000294256.1 ENSMUSG00000129523 (from geneSymbol) uc334dme.1 uc334dme.1 
ENSMUST00000294257.1 ENSMUSG00000129524 ENSMUST00000294257.1 ENSMUSG00000129524 (from geneSymbol) uc334dmf.1 uc334dmf.1 
ENSMUST00000294262.1 ENSMUSG00000129525 ENSMUST00000294262.1 ENSMUSG00000129525 (from geneSymbol) uc334dmk.1 uc334dmk.1 
ENSMUST00000294263.1 ENSMUSG00000129526 ENSMUST00000294263.1 ENSMUSG00000129526 (from geneSymbol) uc334dml.1 uc334dml.1 
ENSMUST00000294265.1 ENSMUSG00000129527 ENSMUST00000294265.1 ENSMUSG00000129527 (from geneSymbol) uc334dmn.1 uc334dmn.1 
ENSMUST00000294296.1 Bloodlinc ENSMUST00000294296.1 Bloodlinc (from geneSymbol) KY467609 uc334dns.1 uc334dns.1 
ENSMUST00000294303.1 ENSMUSG00000129528 ENSMUST00000294303.1 ENSMUSG00000129528 (from geneSymbol) uc334dnz.1 uc334dnz.1 
ENSMUST00000294306.1 ENSMUSG00000129529 ENSMUST00000294306.1 ENSMUSG00000129529 (from geneSymbol) uc334doc.1 uc334doc.1 
ENSMUST00000294307.1 ENSMUSG00000129530 ENSMUST00000294307.1 RIKEN cDNA A430085M09 gene (from RefSeq NR_131142.1) NR_131142 uc334dod.1 uc334dod.1 
ENSMUST00000294308.1 ENSMUSG00000129531 ENSMUST00000294308.1 ENSMUSG00000129531 (from geneSymbol) uc334doe.1 uc334doe.1 
ENSMUST00000294309.1 Gm10690 ENSMUST00000294309.1 Gm10690 (from geneSymbol) uc334dof.1 uc334dof.1 
ENSMUST00000294311.1 ENSMUSG00000129532 ENSMUST00000294311.1 ENSMUSG00000129532 (from geneSymbol) uc334doh.1 uc334doh.1 
ENSMUST00000294312.1 ENSMUSG00000129533 ENSMUST00000294312.1 ENSMUSG00000129533 (from geneSymbol) uc334doi.1 uc334doi.1 
ENSMUST00000294313.1 ENSMUSG00000129534 ENSMUST00000294313.1 ENSMUSG00000129534 (from geneSymbol) uc334doj.1 uc334doj.1 
ENSMUST00000294315.1 ENSMUSG00000129535 ENSMUST00000294315.1 ENSMUSG00000129535 (from geneSymbol) uc334dol.1 uc334dol.1 
ENSMUST00000294318.1 ENSMUSG00000129536 ENSMUST00000294318.1 ENSMUSG00000129536 (from geneSymbol) uc334doo.1 uc334doo.1 
ENSMUST00000294323.1 ENSMUSG00000129537 ENSMUST00000294323.1 ENSMUSG00000129537 (from geneSymbol) uc334dot.1 uc334dot.1 
ENSMUST00000294325.1 Gm31678 ENSMUST00000294325.1 Gm31678 (from geneSymbol) uc334dov.1 uc334dov.1 
ENSMUST00000294333.1 ENSMUSG00000129538 ENSMUST00000294333.1 ENSMUSG00000129538 (from geneSymbol) uc334dpd.1 uc334dpd.1 
ENSMUST00000294334.1 ENSMUSG00000129539 ENSMUST00000294334.1 ENSMUSG00000129539 (from geneSymbol) uc334dpe.1 uc334dpe.1 
ENSMUST00000294335.1 ENSMUSG00000129540 ENSMUST00000294335.1 ENSMUSG00000129540 (from geneSymbol) DQ702732 uc334dpf.1 uc334dpf.1 
ENSMUST00000294337.1 Gm30177 ENSMUST00000294337.1 Gm30177 (from geneSymbol) uc334dph.1 uc334dph.1 
ENSMUST00000294341.1 ENSMUSG00000129541 ENSMUST00000294341.1 ENSMUSG00000129541 (from geneSymbol) uc334dpl.1 uc334dpl.1 
ENSMUST00000294342.1 ENSMUSG00000129542 ENSMUST00000294342.1 ENSMUSG00000129542 (from geneSymbol) uc334dpm.1 uc334dpm.1 
ENSMUST00000294346.1 ENSMUSG00000129543 ENSMUST00000294346.1 ENSMUSG00000129543 (from geneSymbol) uc334dpq.1 uc334dpq.1 
ENSMUST00000294347.1 ENSMUSG00000129544 ENSMUST00000294347.1 ENSMUSG00000129544 (from geneSymbol) uc334dpr.1 uc334dpr.1 
ENSMUST00000294348.1 ENSMUSG00000129545 ENSMUST00000294348.1 ENSMUSG00000129545 (from geneSymbol) uc334dps.1 uc334dps.1 
ENSMUST00000294350.1 ENSMUSG00000129546 ENSMUST00000294350.1 ENSMUSG00000129546 (from geneSymbol) uc334dpu.1 uc334dpu.1 
ENSMUST00000294351.1 ENSMUSG00000129547 ENSMUST00000294351.1 ENSMUSG00000129547 (from geneSymbol) uc334dpv.1 uc334dpv.1 
ENSMUST00000294355.1 ENSMUSG00000129548 ENSMUST00000294355.1 ENSMUSG00000129548 (from geneSymbol) uc334dpz.1 uc334dpz.1 
ENSMUST00000294362.1 ENSMUSG00000129549 ENSMUST00000294362.1 ENSMUSG00000129549 (from geneSymbol) uc334dqg.1 uc334dqg.1 
ENSMUST00000294372.1 ENSMUSG00000129550 ENSMUST00000294372.1 ENSMUSG00000129550 (from geneSymbol) uc334dqq.1 uc334dqq.1 
ENSMUST00000294373.1 ENSMUSG00000129551 ENSMUST00000294373.1 ENSMUSG00000129551 (from geneSymbol) uc334dqr.1 uc334dqr.1 
ENSMUST00000294374.1 ENSMUSG00000129552 ENSMUST00000294374.1 ENSMUSG00000129552 (from geneSymbol) uc334dqs.1 uc334dqs.1 
ENSMUST00000294379.1 ENSMUSG00000129553 ENSMUST00000294379.1 ENSMUSG00000129553 (from geneSymbol) uc334dqx.1 uc334dqx.1 
ENSMUST00000294389.1 ENSMUSG00000129554 ENSMUST00000294389.1 ENSMUSG00000129554 (from geneSymbol) uc334drh.1 uc334drh.1 
ENSMUST00000294390.1 ENSMUSG00000129555 ENSMUST00000294390.1 ENSMUSG00000129555 (from geneSymbol) uc334dri.1 uc334dri.1 
ENSMUST00000294391.1 ENSMUSG00000129556 ENSMUST00000294391.1 ENSMUSG00000129556 (from geneSymbol) uc334drj.1 uc334drj.1 
ENSMUST00000294392.1 Pcsk2os1 ENSMUST00000294392.1 Pcsk2os1 (from geneSymbol) AK035754 uc334drk.1 uc334drk.1 
ENSMUST00000294402.1 ENSMUSG00000129557 ENSMUST00000294402.1 ENSMUSG00000129557 (from geneSymbol) uc334dru.1 uc334dru.1 
ENSMUST00000294405.1 ENSMUSG00000129558 ENSMUST00000294405.1 ENSMUSG00000129558 (from geneSymbol) uc334drx.1 uc334drx.1 
ENSMUST00000294407.1 ENSMUSG00000129559 ENSMUST00000294407.1 ENSMUSG00000129559 (from geneSymbol) uc334drz.1 uc334drz.1 
ENSMUST00000294408.1 ENSMUSG00000129560 ENSMUST00000294408.1 ENSMUSG00000129560 (from geneSymbol) uc334dsa.1 uc334dsa.1 
ENSMUST00000294426.1 ENSMUSG00000129561 ENSMUST00000294426.1 ENSMUSG00000129561 (from geneSymbol) uc334dss.1 uc334dss.1 
ENSMUST00000294432.1 Gm30978 ENSMUST00000294432.1 Gm30978 (from geneSymbol) AK145143 uc334dsy.1 uc334dsy.1 
ENSMUST00000294457.1 Gm34253 ENSMUST00000294457.1 Gm34253 (from geneSymbol) KY467611 uc334dtx.1 uc334dtx.1 
ENSMUST00000294466.1 ENSMUSG00000129563 ENSMUST00000294466.1 ENSMUSG00000129563 (from geneSymbol) uc334dug.1 uc334dug.1 
ENSMUST00000294467.1 ENSMUSG00000129564 ENSMUST00000294467.1 ENSMUSG00000129564 (from geneSymbol) uc334duh.1 uc334duh.1 
ENSMUST00000294478.1 ENSMUSG00000129566 ENSMUST00000294478.1 ENSMUSG00000129566 (from geneSymbol) uc334dum.1 uc334dum.1 
ENSMUST00000294523.1 Gm20646 ENSMUST00000294523.1 predicted gene 20646, transcript variant 2 (from RefSeq NR_168293.1) NR_168293 uc334dwf.1 uc334dwf.1 
ENSMUST00000294533.1 ENSMUSG00000129567 ENSMUST00000294533.1 ENSMUSG00000129567 (from geneSymbol) uc334dwp.1 uc334dwp.1 
ENSMUST00000294534.1 Gm45774 ENSMUST00000294534.1 Gm45774 (from geneSymbol) uc334dwq.1 uc334dwq.1 
ENSMUST00000294538.1 ENSMUSG00000129568 ENSMUST00000294538.1 ENSMUSG00000129568 (from geneSymbol) uc334dwu.1 uc334dwu.1 
ENSMUST00000294539.1 ENSMUSG00000129569 ENSMUST00000294539.1 ENSMUSG00000129569 (from geneSymbol) uc334dwv.1 uc334dwv.1 
ENSMUST00000294540.1 ENSMUSG00000129570 ENSMUST00000294540.1 ENSMUSG00000129570 (from geneSymbol) uc334dww.1 uc334dww.1 
ENSMUST00000294541.1 ENSMUSG00000129571 ENSMUST00000294541.1 ENSMUSG00000129571 (from geneSymbol) uc334dwx.1 uc334dwx.1 
ENSMUST00000294542.1 ENSMUSG00000129572 ENSMUST00000294542.1 ENSMUSG00000129572 (from geneSymbol) uc334dwy.1 uc334dwy.1 
ENSMUST00000294543.1 ENSMUSG00000129573 ENSMUST00000294543.1 ENSMUSG00000129573 (from geneSymbol) uc334dwz.1 uc334dwz.1 
ENSMUST00000294572.1 Gm29243 ENSMUST00000294572.1 Gm29243 (from geneSymbol) uc334dyc.1 uc334dyc.1 
ENSMUST00000294576.1 ENSMUSG00000129574 ENSMUST00000294576.1 ENSMUSG00000129574 (from geneSymbol) uc334dyg.1 uc334dyg.1 
ENSMUST00000294578.1 ENSMUSG00000129575 ENSMUST00000294578.1 ENSMUSG00000129575 (from geneSymbol) uc334dyi.1 uc334dyi.1 
ENSMUST00000294580.1 ENSMUSG00000129576 ENSMUST00000294580.1 ENSMUSG00000129576 (from geneSymbol) uc334dyk.1 uc334dyk.1 
ENSMUST00000294581.1 ENSMUSG00000129577 ENSMUST00000294581.1 ENSMUSG00000129577 (from geneSymbol) uc334dyl.1 uc334dyl.1 
ENSMUST00000294583.1 ENSMUSG00000129578 ENSMUST00000294583.1 ENSMUSG00000129578 (from geneSymbol) uc334dyn.1 uc334dyn.1 
ENSMUST00000294586.1 ENSMUSG00000129579 ENSMUST00000294586.1 ENSMUSG00000129579 (from geneSymbol) uc334dyq.1 uc334dyq.1 
ENSMUST00000294592.1 ENSMUSG00000129580 ENSMUST00000294592.1 ENSMUSG00000129580 (from geneSymbol) uc334dyw.1 uc334dyw.1 
ENSMUST00000294594.1 ENSMUSG00000129581 ENSMUST00000294594.1 ENSMUSG00000129581 (from geneSymbol) uc334dyy.1 uc334dyy.1 
ENSMUST00000294614.1 ENSMUSG00000129582 ENSMUST00000294614.1 ENSMUSG00000129582 (from geneSymbol) uc334dzs.1 uc334dzs.1 
ENSMUST00000294615.1 ENSMUSG00000129583 ENSMUST00000294615.1 ENSMUSG00000129583 (from geneSymbol) uc334dzt.1 uc334dzt.1 
ENSMUST00000294620.1 ENSMUSG00000129584 ENSMUST00000294620.1 ENSMUSG00000129584 (from geneSymbol) uc334dzy.1 uc334dzy.1 
ENSMUST00000294624.1 ENSMUSG00000129587 ENSMUST00000294624.1 ENSMUSG00000129587 (from geneSymbol) uc334eaa.1 uc334eaa.1 
ENSMUST00000294627.1 Gm17491 ENSMUST00000294627.1 Gm17491 (from geneSymbol) KY468180 uc334ead.1 uc334ead.1 
ENSMUST00000294631.1 ENSMUSG00000129588 ENSMUST00000294631.1 ENSMUSG00000129588 (from geneSymbol) LF201629 uc334eah.1 uc334eah.1 
ENSMUST00000294632.1 ENSMUSG00000129589 ENSMUST00000294632.1 ENSMUSG00000129589 (from geneSymbol) uc334eai.1 uc334eai.1 
ENSMUST00000294634.1 ENSMUSG00000129590 ENSMUST00000294634.1 ENSMUSG00000129590 (from geneSymbol) uc334eak.1 uc334eak.1 
ENSMUST00000294635.1 ENSMUSG00000129591 ENSMUST00000294635.1 ENSMUSG00000129591 (from geneSymbol) uc334eal.1 uc334eal.1 
ENSMUST00000294636.1 ENSMUSG00000129592 ENSMUST00000294636.1 ENSMUSG00000129592 (from geneSymbol) uc334eam.1 uc334eam.1 
ENSMUST00000294637.1 1110028F11Rik ENSMUST00000294637.1 1110028F11Rik (from geneSymbol) KY467603 uc334ean.1 uc334ean.1 
ENSMUST00000294638.1 ENSMUSG00000129593 ENSMUST00000294638.1 ENSMUSG00000129593 (from geneSymbol) uc334eao.1 uc334eao.1 
ENSMUST00000294640.1 ENSMUSG00000129594 ENSMUST00000294640.1 ENSMUSG00000129594 (from geneSymbol) uc334eaq.1 uc334eaq.1 
ENSMUST00000294652.1 Gm12996 ENSMUST00000294652.1 Gm12996 (from geneSymbol) uc334ebc.1 uc334ebc.1 
ENSMUST00000294655.1 Gm36457 ENSMUST00000294655.1 Gm36457 (from geneSymbol) uc334ebf.1 uc334ebf.1 
ENSMUST00000294660.1 ENSMUSG00000129595 ENSMUST00000294660.1 ENSMUSG00000129595 (from geneSymbol) uc334ebk.1 uc334ebk.1 
ENSMUST00000294662.1 ENSMUSG00000129596 ENSMUST00000294662.1 ENSMUSG00000129596 (from geneSymbol) uc334ebm.1 uc334ebm.1 
ENSMUST00000294672.1 ENSMUSG00000129597 ENSMUST00000294672.1 ENSMUSG00000129597 (from geneSymbol) uc334ebw.1 uc334ebw.1 
ENSMUST00000294675.1 ENSMUSG00000129598 ENSMUST00000294675.1 ENSMUSG00000129598 (from geneSymbol) uc334ebz.1 uc334ebz.1 
ENSMUST00000294680.1 C130013H08Rik ENSMUST00000294680.1 C130013H08Rik (from geneSymbol) uc334ece.1 uc334ece.1 
ENSMUST00000294682.1 ENSMUSG00000129599 ENSMUST00000294682.1 ENSMUSG00000129599 (from geneSymbol) uc334ecg.1 uc334ecg.1 
ENSMUST00000294686.1 ENSMUSG00000129600 ENSMUST00000294686.1 ENSMUSG00000129600 (from geneSymbol) uc334eck.1 uc334eck.1 
ENSMUST00000294702.1 ENSMUSG00000129601 ENSMUST00000294702.1 ENSMUSG00000129601 (from geneSymbol) uc334eda.1 uc334eda.1 
ENSMUST00000294703.1 ENSMUSG00000129602 ENSMUST00000294703.1 ENSMUSG00000129602 (from geneSymbol) uc334edb.1 uc334edb.1 
ENSMUST00000294704.1 ENSMUSG00000129603 ENSMUST00000294704.1 ENSMUSG00000129603 (from geneSymbol) uc334edc.1 uc334edc.1 
ENSMUST00000294705.1 ENSMUSG00000129604 ENSMUST00000294705.1 ENSMUSG00000129604 (from geneSymbol) uc334edd.1 uc334edd.1 
ENSMUST00000294706.1 ENSMUSG00000129605 ENSMUST00000294706.1 ENSMUSG00000129605 (from geneSymbol) uc334ede.1 uc334ede.1 
ENSMUST00000294729.1 ENSMUSG00000129606 ENSMUST00000294729.1 ENSMUSG00000129606 (from geneSymbol) uc334eeb.1 uc334eeb.1 
ENSMUST00000294730.1 ENSMUSG00000129607 ENSMUST00000294730.1 ENSMUSG00000129607 (from geneSymbol) uc334eec.1 uc334eec.1 
ENSMUST00000294731.1 ENSMUSG00000129608 ENSMUST00000294731.1 ENSMUSG00000129608 (from geneSymbol) uc334eed.1 uc334eed.1 
ENSMUST00000294732.1 Gm56798 ENSMUST00000294732.1 Gm56798 (from geneSymbol) uc334eee.1 uc334eee.1 
ENSMUST00000294734.1 ENSMUSG00000129609 ENSMUST00000294734.1 ENSMUSG00000129609 (from geneSymbol) uc334eeg.1 uc334eeg.1 
ENSMUST00000294735.1 ENSMUSG00000129610 ENSMUST00000294735.1 ENSMUSG00000129610 (from geneSymbol) uc334eeh.1 uc334eeh.1 
ENSMUST00000294736.1 ENSMUSG00000129611 ENSMUST00000294736.1 ENSMUSG00000129611 (from geneSymbol) uc334eei.1 uc334eei.1 
ENSMUST00000294737.1 ENSMUSG00000129612 ENSMUST00000294737.1 ENSMUSG00000129612 (from geneSymbol) uc334eej.1 uc334eej.1 
ENSMUST00000294739.1 Gm49085 ENSMUST00000294739.1 Gm49085 (from geneSymbol) uc334eel.1 uc334eel.1 
ENSMUST00000294741.1 ENSMUSG00000129613 ENSMUST00000294741.1 ENSMUSG00000129613 (from geneSymbol) uc334een.1 uc334een.1 
ENSMUST00000294744.1 ENSMUSG00000129615 ENSMUST00000294744.1 ENSMUSG00000129615 (from geneSymbol) uc334eep.1 uc334eep.1 
ENSMUST00000294745.1 ENSMUSG00000129616 ENSMUST00000294745.1 ENSMUSG00000129616 (from geneSymbol) uc334eeq.1 uc334eeq.1 
ENSMUST00000294746.1 ENSMUSG00000129617 ENSMUST00000294746.1 ENSMUSG00000129617 (from geneSymbol) uc334eer.1 uc334eer.1 
ENSMUST00000294747.1 Gm48884 ENSMUST00000294747.1 Gm48884 (from geneSymbol) uc334ees.1 uc334ees.1 
ENSMUST00000294749.1 ENSMUSG00000129618 ENSMUST00000294749.1 ENSMUSG00000129618 (from geneSymbol) uc334eeu.1 uc334eeu.1 
ENSMUST00000294762.1 Gm29927 ENSMUST00000294762.1 Gm29927 (from geneSymbol) AK039399 uc334efh.1 uc334efh.1 
ENSMUST00000294764.1 Gm29543 ENSMUST00000294764.1 Gm29543 (from geneSymbol) uc334efj.1 uc334efj.1 
ENSMUST00000294768.1 ENSMUSG00000129619 ENSMUST00000294768.1 ENSMUSG00000129619 (from geneSymbol) uc334efn.1 uc334efn.1 
ENSMUST00000294772.1 Gm20742 ENSMUST00000294772.1 Gm20742 (from geneSymbol) AK076995 uc334efr.1 uc334efr.1 
ENSMUST00000294779.1 Gm15777 ENSMUST00000294779.1 Gm15777 (from geneSymbol) uc334efy.1 uc334efy.1 
ENSMUST00000294781.1 ENSMUSG00000121648 ENSMUST00000294781.1 ENSMUSG00000121648 (from geneSymbol) AK139092 uc334ega.1 uc334ega.1 
ENSMUST00000294784.1 ENSMUSG00000129620 ENSMUST00000294784.1 ENSMUSG00000129620 (from geneSymbol) uc334egd.1 uc334egd.1 
ENSMUST00000294788.1 ENSMUSG00000129621 ENSMUST00000294788.1 ENSMUSG00000129621 (from geneSymbol) uc334egh.1 uc334egh.1 
ENSMUST00000294792.1 ENSMUSG00000129622 ENSMUST00000294792.1 ENSMUSG00000129622 (from geneSymbol) uc334egl.1 uc334egl.1 
ENSMUST00000294794.1 ENSMUSG00000129623 ENSMUST00000294794.1 ENSMUSG00000129623 (from geneSymbol) uc334egn.1 uc334egn.1 
ENSMUST00000294795.1 ENSMUSG00000129624 ENSMUST00000294795.1 ENSMUSG00000129624 (from geneSymbol) uc334ego.1 uc334ego.1 
ENSMUST00000294797.1 ENSMUSG00000129625 ENSMUST00000294797.1 ENSMUSG00000129625 (from geneSymbol) uc334egq.1 uc334egq.1 
ENSMUST00000294798.1 ENSMUSG00000129626 ENSMUST00000294798.1 ENSMUSG00000129626 (from geneSymbol) uc334egr.1 uc334egr.1 
ENSMUST00000294801.1 ENSMUSG00000129627 ENSMUST00000294801.1 ENSMUSG00000129627 (from geneSymbol) uc334egu.1 uc334egu.1 
ENSMUST00000294802.1 Gm31266 ENSMUST00000294802.1 Gm31266 (from geneSymbol) uc334egv.1 uc334egv.1 
ENSMUST00000294803.1 ENSMUSG00000129628 ENSMUST00000294803.1 ENSMUSG00000129628 (from geneSymbol) uc334egw.1 uc334egw.1 
ENSMUST00000294808.1 ENSMUSG00000129629 ENSMUST00000294808.1 ENSMUSG00000129629 (from geneSymbol) uc334ehb.1 uc334ehb.1 
ENSMUST00000294811.1 Gm39469 ENSMUST00000294811.1 Gm39469 (from geneSymbol) uc334ehe.1 uc334ehe.1 
ENSMUST00000294818.1 ENSMUSG00000129630 ENSMUST00000294818.1 ENSMUSG00000129630 (from geneSymbol) uc334ehl.1 uc334ehl.1 
ENSMUST00000294822.1 ENSMUSG00000129631 ENSMUST00000294822.1 ENSMUSG00000129631 (from geneSymbol) uc334ehp.1 uc334ehp.1 
ENSMUST00000294824.1 ENSMUSG00000129633 ENSMUST00000294824.1 ENSMUSG00000129633 (from geneSymbol) uc334ehq.1 uc334ehq.1 
ENSMUST00000294826.1 Gm34672 ENSMUST00000294826.1 Gm34672 (from geneSymbol) uc334ehs.1 uc334ehs.1 
ENSMUST00000294835.1 ENSMUSG00000121846 ENSMUST00000294835.1 ENSMUSG00000121846 (from geneSymbol) uc334eib.1 uc334eib.1 
ENSMUST00000294836.1 ENSMUSG00000129634 ENSMUST00000294836.1 ENSMUSG00000129634 (from geneSymbol) AK048215 uc334eic.1 uc334eic.1 
ENSMUST00000294838.1 ENSMUSG00000129635 ENSMUST00000294838.1 ENSMUSG00000129635 (from geneSymbol) uc334eie.1 uc334eie.1 
ENSMUST00000294839.1 ENSMUSG00000129636 ENSMUST00000294839.1 ENSMUSG00000129636 (from geneSymbol) uc334eif.1 uc334eif.1 
ENSMUST00000294840.1 ENSMUSG00000129637 ENSMUST00000294840.1 ENSMUSG00000129637 (from geneSymbol) uc334eig.1 uc334eig.1 
ENSMUST00000294841.1 ENSMUSG00000129638 ENSMUST00000294841.1 ENSMUSG00000129638 (from geneSymbol) uc334eih.1 uc334eih.1 
ENSMUST00000294844.1 ENSMUSG00000129639 ENSMUST00000294844.1 ENSMUSG00000129639 (from geneSymbol) uc334eik.1 uc334eik.1 
ENSMUST00000294847.1 1700121N20Rik ENSMUST00000294847.1 1700121N20Rik (from geneSymbol) AK007234 uc334ein.1 uc334ein.1 
ENSMUST00000294856.1 ENSMUSG00000129640 ENSMUST00000294856.1 ENSMUSG00000129640 (from geneSymbol) uc334eiw.1 uc334eiw.1 
ENSMUST00000294858.1 ENSMUSG00000129641 ENSMUST00000294858.1 ENSMUSG00000129641 (from geneSymbol) uc334eiy.1 uc334eiy.1 
ENSMUST00000294859.1 ENSMUSG00000129642 ENSMUST00000294859.1 ENSMUSG00000129642 (from geneSymbol) uc334eiz.1 uc334eiz.1 
ENSMUST00000294860.1 ENSMUSG00000129643 ENSMUST00000294860.1 ENSMUSG00000129643 (from geneSymbol) uc334eja.1 uc334eja.1 
ENSMUST00000294870.1 ENSMUSG00000129644 ENSMUST00000294870.1 ENSMUSG00000129644 (from geneSymbol) uc334ejk.1 uc334ejk.1 
ENSMUST00000294871.1 ENSMUSG00000129645 ENSMUST00000294871.1 ENSMUSG00000129645 (from geneSymbol) BC019681 uc334ejl.1 uc334ejl.1 
ENSMUST00000294872.1 ENSMUSG00000129646 ENSMUST00000294872.1 ENSMUSG00000129646 (from geneSymbol) uc334ejm.1 uc334ejm.1 
ENSMUST00000294875.1 ENSMUSG00000129647 ENSMUST00000294875.1 ENSMUSG00000129647 (from geneSymbol) uc334ejp.1 uc334ejp.1 
ENSMUST00000294877.1 ENSMUSG00000129648 ENSMUST00000294877.1 ENSMUSG00000129648 (from geneSymbol) uc334ejr.1 uc334ejr.1 
ENSMUST00000294878.1 Gm26682 ENSMUST00000294878.1 Gm26682 (from geneSymbol) AK020518 uc334ejs.1 uc334ejs.1 
ENSMUST00000294890.1 Gm2814 ENSMUST00000294890.1 Gm2814 (from geneSymbol) AK144055 uc334eke.1 uc334eke.1 
ENSMUST00000294924.1 ENSMUSG00000129649 ENSMUST00000294924.1 ENSMUSG00000129649 (from geneSymbol) uc334elm.1 uc334elm.1 
ENSMUST00000294925.1 ENSMUSG00000129650 ENSMUST00000294925.1 ENSMUSG00000129650 (from geneSymbol) uc334eln.1 uc334eln.1 
ENSMUST00000294926.1 ENSMUSG00000129651 ENSMUST00000294926.1 ENSMUSG00000129651 (from geneSymbol) uc334elo.1 uc334elo.1 
ENSMUST00000294933.1 ENSMUSG00000129652 ENSMUST00000294933.1 ENSMUSG00000129652 (from geneSymbol) uc334elu.1 uc334elu.1 
ENSMUST00000294934.1 ENSMUSG00000129653 ENSMUST00000294934.1 ENSMUSG00000129653 (from geneSymbol) uc334elv.1 uc334elv.1 
ENSMUST00000294935.1 ENSMUSG00000129654 ENSMUST00000294935.1 ENSMUSG00000129654 (from geneSymbol) uc334elw.1 uc334elw.1 
ENSMUST00000294937.1 ENSMUSG00000129655 ENSMUST00000294937.1 ENSMUSG00000129655 (from geneSymbol) uc334ely.1 uc334ely.1 
ENSMUST00000294938.1 ENSMUSG00000129656 ENSMUST00000294938.1 ENSMUSG00000129656 (from geneSymbol) uc334elz.1 uc334elz.1 
ENSMUST00000294939.1 ENSMUSG00000129657 ENSMUST00000294939.1 ENSMUSG00000129657 (from geneSymbol) uc334ema.1 uc334ema.1 
ENSMUST00000294940.1 ENSMUSG00000129658 ENSMUST00000294940.1 ENSMUSG00000129658 (from geneSymbol) uc334emb.1 uc334emb.1 
ENSMUST00000294941.1 ENSMUSG00000129659 ENSMUST00000294941.1 ENSMUSG00000129659 (from geneSymbol) uc334emc.1 uc334emc.1 
ENSMUST00000294942.1 ENSMUSG00000129660 ENSMUST00000294942.1 ENSMUSG00000129660 (from geneSymbol) uc334emd.1 uc334emd.1 
ENSMUST00000294944.1 ENSMUSG00000129661 ENSMUST00000294944.1 ENSMUSG00000129661 (from geneSymbol) uc334emf.1 uc334emf.1 
ENSMUST00000294947.1 Gm48956 ENSMUST00000294947.1 Gm48956 (from geneSymbol) uc334emi.1 uc334emi.1 
ENSMUST00000294955.1 ENSMUSG00000129662 ENSMUST00000294955.1 ENSMUSG00000129662 (from geneSymbol) uc334emq.1 uc334emq.1 
ENSMUST00000294962.1 ENSMUSG00000129663 ENSMUST00000294962.1 ENSMUSG00000129663 (from geneSymbol) uc334emx.1 uc334emx.1 
ENSMUST00000294966.1 2810433D01Rik ENSMUST00000294966.1 2810433D01Rik (from geneSymbol) AK019272 uc334ena.1 uc334ena.1 
ENSMUST00000294968.1 ENSMUSG00000129665 ENSMUST00000294968.1 ENSMUSG00000129665 (from geneSymbol) uc334enc.1 uc334enc.1 
ENSMUST00000294973.1 Tslrn1 ENSMUST00000294973.1 Tslrn1 (from geneSymbol) AK006108 uc334enh.1 uc334enh.1 
ENSMUST00000295005.1 ENSMUSG00000129666 ENSMUST00000295005.1 ENSMUSG00000129666 (from geneSymbol) uc334eon.1 uc334eon.1 
ENSMUST00000295007.1 ENSMUSG00000129667 ENSMUST00000295007.1 ENSMUSG00000129667 (from geneSymbol) uc334eop.1 uc334eop.1 
ENSMUST00000295008.1 ENSMUSG00000129668 ENSMUST00000295008.1 ENSMUSG00000129668 (from geneSymbol) uc334eoq.1 uc334eoq.1 
ENSMUST00000295009.1 ENSMUSG00000129669 ENSMUST00000295009.1 ENSMUSG00000129669 (from geneSymbol) uc334eor.1 uc334eor.1 
ENSMUST00000295010.1 ENSMUSG00000129670 ENSMUST00000295010.1 ENSMUSG00000129670 (from geneSymbol) uc334eos.1 uc334eos.1 
ENSMUST00000295014.1 Gm39770 ENSMUST00000295014.1 Gm39770 (from geneSymbol) uc334eow.1 uc334eow.1 
ENSMUST00000295027.1 ENSMUSG00000129671 ENSMUST00000295027.1 ENSMUSG00000129671 (from geneSymbol) uc334epj.1 uc334epj.1 
ENSMUST00000295033.1 ENSMUSG00000129672 ENSMUST00000295033.1 ENSMUSG00000129672 (from geneSymbol) uc334epp.1 uc334epp.1 
ENSMUST00000295045.1 ENSMUSG00000129673 ENSMUST00000295045.1 ENSMUSG00000129673 (from geneSymbol) uc334eqb.1 uc334eqb.1 
ENSMUST00000295046.1 ENSMUSG00000129674 ENSMUST00000295046.1 ENSMUSG00000129674 (from geneSymbol) uc334eqc.1 uc334eqc.1 
ENSMUST00000295047.1 Gm39228 ENSMUST00000295047.1 Gm39228 (from geneSymbol) uc334eqd.1 uc334eqd.1 
ENSMUST00000295048.1 ENSMUSG00000129675 ENSMUST00000295048.1 ENSMUSG00000129675 (from geneSymbol) uc334eqe.1 uc334eqe.1 
ENSMUST00000295052.1 ENSMUSG00000129676 ENSMUST00000295052.1 ENSMUSG00000129676 (from geneSymbol) uc334eqi.1 uc334eqi.1 
ENSMUST00000295053.1 ENSMUSG00000129677 ENSMUST00000295053.1 ENSMUSG00000129677 (from geneSymbol) uc334eqj.1 uc334eqj.1 
ENSMUST00000295063.1 ENSMUSG00000129678 ENSMUST00000295063.1 ENSMUSG00000129678 (from geneSymbol) uc334eqt.1 uc334eqt.1 
ENSMUST00000295064.1 ENSMUSG00000129679 ENSMUST00000295064.1 ENSMUSG00000129679 (from geneSymbol) uc334equ.1 uc334equ.1 
ENSMUST00000295113.1 ENSMUSG00000129680 ENSMUST00000295113.1 ENSMUSG00000129680 (from geneSymbol) uc334esi.1 uc334esi.1 
ENSMUST00000295114.1 ENSMUSG00000129681 ENSMUST00000295114.1 ENSMUSG00000129681 (from geneSymbol) uc334esj.1 uc334esj.1 
ENSMUST00000295116.1 ENSMUSG00000129682 ENSMUST00000295116.1 ENSMUSG00000129682 (from geneSymbol) uc334esl.1 uc334esl.1 
ENSMUST00000295117.1 ENSMUSG00000129683 ENSMUST00000295117.1 ENSMUSG00000129683 (from geneSymbol) uc334esm.1 uc334esm.1 
ENSMUST00000295120.1 ENSMUSG00000129684 ENSMUST00000295120.1 ENSMUSG00000129684 (from geneSymbol) uc334esp.1 uc334esp.1 
ENSMUST00000295121.1 ENSMUSG00000129685 ENSMUST00000295121.1 ENSMUSG00000129685 (from geneSymbol) uc334esq.1 uc334esq.1 
ENSMUST00000295122.1 ENSMUSG00000129686 ENSMUST00000295122.1 ENSMUSG00000129686 (from geneSymbol) uc334esr.1 uc334esr.1 
ENSMUST00000295123.1 ENSMUSG00000129687 ENSMUST00000295123.1 ENSMUSG00000129687 (from geneSymbol) uc334ess.1 uc334ess.1 
ENSMUST00000295124.1 ENSMUSG00000129688 ENSMUST00000295124.1 ENSMUSG00000129688 (from geneSymbol) AK041002 uc334est.1 uc334est.1 
ENSMUST00000295126.1 ENSMUSG00000129689 ENSMUST00000295126.1 ENSMUSG00000129689 (from geneSymbol) uc334esv.1 uc334esv.1 
ENSMUST00000295131.1 ENSMUSG00000129690 ENSMUST00000295131.1 ENSMUSG00000129690 (from geneSymbol) uc334eta.1 uc334eta.1 
ENSMUST00000295151.1 ENSMUSG00000129691 ENSMUST00000295151.1 ENSMUSG00000129691 (from geneSymbol) uc334ett.1 uc334ett.1 
ENSMUST00000295152.1 ENSMUSG00000129692 ENSMUST00000295152.1 ENSMUSG00000129692 (from geneSymbol) uc334etu.1 uc334etu.1 
ENSMUST00000295155.1 ENSMUSG00000129693 ENSMUST00000295155.1 ENSMUSG00000129693 (from geneSymbol) uc334etx.1 uc334etx.1 
ENSMUST00000295165.1 ENSMUSG00000129694 ENSMUST00000295165.1 ENSMUSG00000129694 (from geneSymbol) uc334euh.1 uc334euh.1 
ENSMUST00000295166.1 ENSMUSG00000129695 ENSMUST00000295166.1 ENSMUSG00000129695 (from geneSymbol) uc334eui.1 uc334eui.1 
ENSMUST00000295168.1 ENSMUSG00000129696 ENSMUST00000295168.1 ENSMUSG00000129696 (from geneSymbol) uc334euk.1 uc334euk.1 
ENSMUST00000295169.1 ENSMUSG00000129697 ENSMUST00000295169.1 ENSMUSG00000129697 (from geneSymbol) uc334eul.1 uc334eul.1 
ENSMUST00000295170.1 ENSMUSG00000129698 ENSMUST00000295170.1 ENSMUSG00000129698 (from geneSymbol) uc334eum.1 uc334eum.1 
ENSMUST00000295172.1 ENSMUSG00000129699 ENSMUST00000295172.1 ENSMUSG00000129699 (from geneSymbol) uc334euo.1 uc334euo.1 
ENSMUST00000295216.1 ENSMUSG00000129700 ENSMUST00000295216.1 ENSMUSG00000129700 (from geneSymbol) uc334ewe.1 uc334ewe.1 
ENSMUST00000295217.1 ENSMUSG00000129701 ENSMUST00000295217.1 ENSMUSG00000129701 (from geneSymbol) uc334ewf.1 uc334ewf.1 
ENSMUST00000295219.1 ENSMUSG00000129702 ENSMUST00000295219.1 ENSMUSG00000129702 (from geneSymbol) uc334ewh.1 uc334ewh.1 
ENSMUST00000295224.1 ENSMUSG00000129703 ENSMUST00000295224.1 ENSMUSG00000129703 (from geneSymbol) uc334ewm.1 uc334ewm.1 
ENSMUST00000295225.1 ENSMUSG00000129704 ENSMUST00000295225.1 ENSMUSG00000129704 (from geneSymbol) uc334ewn.1 uc334ewn.1 
ENSMUST00000295226.1 ENSMUSG00000129705 ENSMUST00000295226.1 ENSMUSG00000129705 (from geneSymbol) uc334ewo.1 uc334ewo.1 
ENSMUST00000295229.1 1700030E10Rik ENSMUST00000295229.1 1700030E10Rik (from geneSymbol) AK006537 uc334ewr.1 uc334ewr.1 
ENSMUST00000295239.1 ENSMUSG00000129706 ENSMUST00000295239.1 ENSMUSG00000129706 (from geneSymbol) uc334exb.1 uc334exb.1 
ENSMUST00000295240.1 ENSMUSG00000129707 ENSMUST00000295240.1 ENSMUSG00000129707 (from geneSymbol) uc334exc.1 uc334exc.1 
ENSMUST00000295241.1 ENSMUSG00000129708 ENSMUST00000295241.1 ENSMUSG00000129708 (from geneSymbol) uc334exd.1 uc334exd.1 
ENSMUST00000295244.1 ENSMUSG00000129709 ENSMUST00000295244.1 ENSMUSG00000129709 (from geneSymbol) uc334exg.1 uc334exg.1 
ENSMUST00000295246.1 ENSMUSG00000129710 ENSMUST00000295246.1 ENSMUSG00000129710 (from geneSymbol) uc334exh.1 uc334exh.1 
ENSMUST00000295258.1 ENSMUSG00000129711 ENSMUST00000295258.1 ENSMUSG00000129711 (from geneSymbol) uc334ext.1 uc334ext.1 
ENSMUST00000295259.1 Gm34558 ENSMUST00000295259.1 Gm34558 (from geneSymbol) uc334exu.1 uc334exu.1 
ENSMUST00000295267.1 ENSMUSG00000129712 ENSMUST00000295267.1 ENSMUSG00000129712 (from geneSymbol) uc334eyc.1 uc334eyc.1 
ENSMUST00000295274.1 ENSMUSG00000129713 ENSMUST00000295274.1 ENSMUSG00000129713 (from geneSymbol) uc334eyj.1 uc334eyj.1 
ENSMUST00000295283.1 ENSMUSG00000129714 ENSMUST00000295283.1 ENSMUSG00000129714 (from geneSymbol) uc334eys.1 uc334eys.1 
ENSMUST00000295293.1 Gm16233 ENSMUST00000295293.1 Gm16233 (from geneSymbol) AK054018 uc334ezc.1 uc334ezc.1 
ENSMUST00000295295.1 ENSMUSG00000129715 ENSMUST00000295295.1 ENSMUSG00000129715 (from geneSymbol) uc334eze.1 uc334eze.1 
ENSMUST00000295298.1 ENSMUSG00000129716 ENSMUST00000295298.1 ENSMUSG00000129716 (from geneSymbol) uc334ezh.1 uc334ezh.1 
ENSMUST00000295300.1 ENSMUSG00000129717 ENSMUST00000295300.1 ENSMUSG00000129717 (from geneSymbol) uc334ezj.1 uc334ezj.1 
ENSMUST00000295301.1 ENSMUSG00000129718 ENSMUST00000295301.1 ENSMUSG00000129718 (from geneSymbol) uc334ezk.1 uc334ezk.1 
ENSMUST00000295302.1 Gm38832 ENSMUST00000295302.1 Gm38832 (from geneSymbol) AK039589 uc334ezl.1 uc334ezl.1 
ENSMUST00000295304.1 ENSMUSG00000129719 ENSMUST00000295304.1 ENSMUSG00000129719 (from geneSymbol) uc334ezn.1 uc334ezn.1 
ENSMUST00000295305.1 ENSMUSG00000129720 ENSMUST00000295305.1 ENSMUSG00000129720 (from geneSymbol) uc334ezo.1 uc334ezo.1 
ENSMUST00000295322.1 Gm44507 ENSMUST00000295322.1 Gm44507 (from geneSymbol) uc334fae.1 uc334fae.1 
ENSMUST00000295370.1 ENSMUSG00000129721 ENSMUST00000295370.1 ENSMUSG00000129721 (from geneSymbol) uc334fca.1 uc334fca.1 
ENSMUST00000295371.1 ENSMUSG00000129722 ENSMUST00000295371.1 ENSMUSG00000129722 (from geneSymbol) uc334fcb.1 uc334fcb.1 
ENSMUST00000295372.1 ENSMUSG00000129723 ENSMUST00000295372.1 ENSMUSG00000129723 (from geneSymbol) uc334fcc.1 uc334fcc.1 
ENSMUST00000295375.1 ENSMUSG00000129724 ENSMUST00000295375.1 ENSMUSG00000129724 (from geneSymbol) uc334fcf.1 uc334fcf.1 
ENSMUST00000295377.1 ENSMUSG00000129725 ENSMUST00000295377.1 ENSMUSG00000129725 (from geneSymbol) uc334fch.1 uc334fch.1 
ENSMUST00000295379.1 ENSMUSG00000129726 ENSMUST00000295379.1 ENSMUSG00000129726 (from geneSymbol) uc334fcj.1 uc334fcj.1 
ENSMUST00000295382.1 ENSMUSG00000129727 ENSMUST00000295382.1 ENSMUSG00000129727 (from geneSymbol) uc334fcm.1 uc334fcm.1 
ENSMUST00000295386.1 ENSMUSG00000129728 ENSMUST00000295386.1 ENSMUSG00000129728 (from geneSymbol) uc334fcq.1 uc334fcq.1 
ENSMUST00000295395.1 ENSMUSG00000129729 ENSMUST00000295395.1 ENSMUSG00000129729 (from geneSymbol) uc334fcz.1 uc334fcz.1 
ENSMUST00000295397.1 ENSMUSG00000129730 ENSMUST00000295397.1 ENSMUSG00000129730 (from geneSymbol) uc334fdb.1 uc334fdb.1 
ENSMUST00000295398.1 ENSMUSG00000129731 ENSMUST00000295398.1 ENSMUSG00000129731 (from geneSymbol) uc334fdc.1 uc334fdc.1 
ENSMUST00000295400.1 ENSMUSG00000129732 ENSMUST00000295400.1 ENSMUSG00000129732 (from geneSymbol) uc334fde.1 uc334fde.1 
ENSMUST00000295402.1 ENSMUSG00000129733 ENSMUST00000295402.1 ENSMUSG00000129733 (from geneSymbol) uc334fdg.1 uc334fdg.1 
ENSMUST00000295404.1 ENSMUSG00000129734 ENSMUST00000295404.1 ENSMUSG00000129734 (from geneSymbol) uc334fdi.1 uc334fdi.1 
ENSMUST00000295417.1 ENSMUSG00000129735 ENSMUST00000295417.1 ENSMUSG00000129735 (from geneSymbol) uc334fdv.1 uc334fdv.1 
ENSMUST00000295418.1 ENSMUSG00000129736 ENSMUST00000295418.1 ENSMUSG00000129736 (from geneSymbol) uc334fdw.1 uc334fdw.1 
ENSMUST00000295419.1 ENSMUSG00000129737 ENSMUST00000295419.1 ENSMUSG00000129737 (from geneSymbol) uc334fdx.1 uc334fdx.1 
ENSMUST00000295428.1 Gm44955 ENSMUST00000295428.1 Gm44955 (from geneSymbol) AK014460 uc334feg.1 uc334feg.1 
ENSMUST00000295456.1 ENSMUSG00000129738 ENSMUST00000295456.1 ENSMUSG00000129738 (from geneSymbol) uc334ffi.1 uc334ffi.1 
ENSMUST00000295458.1 ENSMUSG00000129739 ENSMUST00000295458.1 ENSMUSG00000129739 (from geneSymbol) uc334ffk.1 uc334ffk.1 
ENSMUST00000295460.1 ENSMUSG00000129740 ENSMUST00000295460.1 ENSMUSG00000129740 (from geneSymbol) uc334ffm.1 uc334ffm.1 
ENSMUST00000295467.1 ENSMUSG00000129741 ENSMUST00000295467.1 ENSMUSG00000129741 (from geneSymbol) uc334fft.1 uc334fft.1 
ENSMUST00000295472.1 ENSMUSG00000129742 ENSMUST00000295472.1 ENSMUSG00000129742 (from geneSymbol) uc334ffy.1 uc334ffy.1 
ENSMUST00000295474.1 ENSMUSG00000129743 ENSMUST00000295474.1 ENSMUSG00000129743 (from geneSymbol) uc334fga.1 uc334fga.1 
ENSMUST00000295475.1 ENSMUSG00000129744 ENSMUST00000295475.1 ENSMUSG00000129744 (from geneSymbol) uc334fgb.1 uc334fgb.1 
ENSMUST00000295476.1 ENSMUSG00000129745 ENSMUST00000295476.1 ENSMUSG00000129745 (from geneSymbol) uc334fgc.1 uc334fgc.1 
ENSMUST00000295486.1 Gm5468 ENSMUST00000295486.1 Gm5468 (from geneSymbol) AK139483 uc334fgm.1 uc334fgm.1 
ENSMUST00000295495.1 ENSMUSG00000129746 ENSMUST00000295495.1 ENSMUSG00000129746 (from geneSymbol) uc334fgv.1 uc334fgv.1 
ENSMUST00000295508.1 ENSMUSG00000129747 ENSMUST00000295508.1 ENSMUSG00000129747 (from geneSymbol) uc334fhi.1 uc334fhi.1 
ENSMUST00000295513.1 Gm32515 ENSMUST00000295513.1 Gm32515 (from geneSymbol) uc334fhn.1 uc334fhn.1 
ENSMUST00000295522.1 ENSMUSG00000129749 ENSMUST00000295522.1 ENSMUSG00000129749 (from geneSymbol) uc334fht.1 uc334fht.1 
ENSMUST00000295523.1 ENSMUSG00000129750 ENSMUST00000295523.1 ENSMUSG00000129750 (from geneSymbol) uc334fhu.1 uc334fhu.1 
ENSMUST00000295524.1 ENSMUSG00000129751 ENSMUST00000295524.1 ENSMUSG00000129751 (from geneSymbol) uc334fhv.1 uc334fhv.1 
ENSMUST00000295526.1 ENSMUSG00000129752 ENSMUST00000295526.1 ENSMUSG00000129752 (from geneSymbol) uc334fhx.1 uc334fhx.1 
ENSMUST00000295528.1 ENSMUSG00000129753 ENSMUST00000295528.1 ENSMUSG00000129753 (from geneSymbol) AK039689 uc334fhy.1 uc334fhy.1 
ENSMUST00000295532.1 ENSMUSG00000129754 ENSMUST00000295532.1 ENSMUSG00000129754 (from geneSymbol) uc334fic.1 uc334fic.1 
ENSMUST00000295547.1 ENSMUSG00000129755 ENSMUST00000295547.1 ENSMUSG00000129755 (from geneSymbol) uc334fir.1 uc334fir.1 
ENSMUST00000295550.1 ENSMUSG00000129756 ENSMUST00000295550.1 ENSMUSG00000129756 (from geneSymbol) uc334fiu.1 uc334fiu.1 
ENSMUST00000295557.1 ENSMUSG00000129757 ENSMUST00000295557.1 ENSMUSG00000129757 (from geneSymbol) uc334fjb.1 uc334fjb.1 
ENSMUST00000295558.1 ENSMUSG00000129758 ENSMUST00000295558.1 ENSMUSG00000129758 (from geneSymbol) uc334fjc.1 uc334fjc.1 
ENSMUST00000295560.1 ENSMUSG00000129759 ENSMUST00000295560.1 ENSMUSG00000129759 (from geneSymbol) uc334fje.1 uc334fje.1 
ENSMUST00000295563.1 ENSMUSG00000129760 ENSMUST00000295563.1 ENSMUSG00000129760 (from geneSymbol) uc334fjh.1 uc334fjh.1 
ENSMUST00000295571.1 ENSMUSG00000129761 ENSMUST00000295571.1 ENSMUSG00000129761 (from geneSymbol) uc334fjn.1 uc334fjn.1 
ENSMUST00000295572.1 ENSMUSG00000129762 ENSMUST00000295572.1 ENSMUSG00000129762 (from geneSymbol) uc334fjo.1 uc334fjo.1 
ENSMUST00000295574.1 D830013O20Rik ENSMUST00000295574.1 D830013O20Rik (from geneSymbol) AK085818 uc334fjq.1 uc334fjq.1 
ENSMUST00000295601.1 6720473M11Rik ENSMUST00000295601.1 RIKEN cDNA 6720473M11 gene (from RefSeq NR_165178.1) NR_165178 uc334fkr.1 uc334fkr.1 
ENSMUST00000295603.1 ENSMUSG00000129764 ENSMUST00000295603.1 ENSMUSG00000129764 (from geneSymbol) uc334fkt.1 uc334fkt.1 
ENSMUST00000295605.1 ENSMUSG00000129765 ENSMUST00000295605.1 ENSMUSG00000129765 (from geneSymbol) uc334fkv.1 uc334fkv.1 
ENSMUST00000295607.1 ENSMUSG00000129766 ENSMUST00000295607.1 ENSMUSG00000129766 (from geneSymbol) uc334fkx.1 uc334fkx.1 
ENSMUST00000295614.1 ENSMUSG00000129767 ENSMUST00000295614.1 ENSMUSG00000129767 (from geneSymbol) uc334fle.1 uc334fle.1 
ENSMUST00000295615.1 ENSMUSG00000129768 ENSMUST00000295615.1 ENSMUSG00000129768 (from geneSymbol) uc334flf.1 uc334flf.1 
ENSMUST00000295616.1 ENSMUSG00000129769 ENSMUST00000295616.1 ENSMUSG00000129769 (from geneSymbol) uc334flg.1 uc334flg.1 
ENSMUST00000295617.1 ENSMUSG00000129770 ENSMUST00000295617.1 ENSMUSG00000129770 (from geneSymbol) uc334flh.1 uc334flh.1 
ENSMUST00000295619.1 ENSMUSG00000129771 ENSMUST00000295619.1 ENSMUSG00000129771 (from geneSymbol) uc334flj.1 uc334flj.1 
ENSMUST00000295624.1 ENSMUSG00000129772 ENSMUST00000295624.1 ENSMUSG00000129772 (from geneSymbol) uc334flo.1 uc334flo.1 
ENSMUST00000295628.1 Mir181a-1hg ENSMUST00000295628.1 Mir181a-1hg (from geneSymbol) uc334fls.1 uc334fls.1 
ENSMUST00000295659.1 ENSMUSG00000129773 ENSMUST00000295659.1 ENSMUSG00000129773 (from geneSymbol) uc334fmx.1 uc334fmx.1 
ENSMUST00000295673.1 ENSMUSG00000129774 ENSMUST00000295673.1 ENSMUSG00000129774 (from geneSymbol) uc334fnl.1 uc334fnl.1 
ENSMUST00000295677.1 ENSMUSG00000129775 ENSMUST00000295677.1 ENSMUSG00000129775 (from geneSymbol) uc334fnp.1 uc334fnp.1 
ENSMUST00000295689.1 ENSMUSG00000129776 ENSMUST00000295689.1 ENSMUSG00000129776 (from geneSymbol) uc334fob.1 uc334fob.1 
ENSMUST00000295692.1 ENSMUSG00000129777 ENSMUST00000295692.1 ENSMUSG00000129777 (from geneSymbol) uc334foe.1 uc334foe.1 
ENSMUST00000295693.1 ENSMUSG00000129778 ENSMUST00000295693.1 ENSMUSG00000129778 (from geneSymbol) uc334fof.1 uc334fof.1 
ENSMUST00000295715.1 Gm43358 ENSMUST00000295715.1 Gm43358 (from geneSymbol) uc334fpb.1 uc334fpb.1 
ENSMUST00000295729.1 ENSMUSG00000129779 ENSMUST00000295729.1 ENSMUSG00000129779 (from geneSymbol) uc334fpp.1 uc334fpp.1 
ENSMUST00000295730.1 Gm26800 ENSMUST00000295730.1 Gm26800 (from geneSymbol) uc334fpq.1 uc334fpq.1 
ENSMUST00000295731.1 ENSMUSG00000129780 ENSMUST00000295731.1 ENSMUSG00000129780 (from geneSymbol) uc334fpr.1 uc334fpr.1 
ENSMUST00000295736.1 Gm17089 ENSMUST00000295736.1 Gm17089 (from geneSymbol) AK079625 uc334fpw.1 uc334fpw.1 
ENSMUST00000295740.1 ENSMUSG00000129781 ENSMUST00000295740.1 ENSMUSG00000129781 (from geneSymbol) uc334fqa.1 uc334fqa.1 
ENSMUST00000295741.1 ENSMUSG00000129782 ENSMUST00000295741.1 ENSMUSG00000129782 (from geneSymbol) uc334fqb.1 uc334fqb.1 
ENSMUST00000295742.1 5830428M24Rik ENSMUST00000295742.1 5830428M24Rik (from geneSymbol) AK017954 uc334fqc.1 uc334fqc.1 
ENSMUST00000295776.1 ENSMUSG00000129783 ENSMUST00000295776.1 ENSMUSG00000129783 (from geneSymbol) uc334frk.1 uc334frk.1 
ENSMUST00000295777.1 E130317F20Rik ENSMUST00000295777.1 E130317F20Rik (from geneSymbol) uc334frl.1 uc334frl.1 
ENSMUST00000295787.1 ENSMUSG00000129784 ENSMUST00000295787.1 ENSMUSG00000129784 (from geneSymbol) uc334frv.1 uc334frv.1 
ENSMUST00000295788.1 ENSMUSG00000129785 ENSMUST00000295788.1 ENSMUSG00000129785 (from geneSymbol) uc334frw.1 uc334frw.1 
ENSMUST00000295789.1 ENSMUSG00000129786 ENSMUST00000295789.1 ENSMUSG00000129786 (from geneSymbol) uc334frx.1 uc334frx.1 
ENSMUST00000295791.1 ENSMUSG00000129787 ENSMUST00000295791.1 ENSMUSG00000129787 (from geneSymbol) uc334frz.1 uc334frz.1 
ENSMUST00000295795.1 ENSMUSG00000129789 ENSMUST00000295795.1 ENSMUSG00000129789 (from geneSymbol) uc334fsc.1 uc334fsc.1 
ENSMUST00000295796.1 ENSMUSG00000129790 ENSMUST00000295796.1 ENSMUSG00000129790 (from geneSymbol) uc334fsd.1 uc334fsd.1 
ENSMUST00000295797.1 ENSMUSG00000129791 ENSMUST00000295797.1 ENSMUSG00000129791 (from geneSymbol) uc334fse.1 uc334fse.1 
ENSMUST00000295799.1 ENSMUSG00000129792 ENSMUST00000295799.1 ENSMUSG00000129792 (from geneSymbol) uc334fsg.1 uc334fsg.1 
ENSMUST00000295801.1 Gm31793 ENSMUST00000295801.1 Gm31793 (from geneSymbol) AK089146 uc334fsi.1 uc334fsi.1 
ENSMUST00000295809.1 ENSMUSG00000129793 ENSMUST00000295809.1 ENSMUSG00000129793 (from geneSymbol) uc334fsq.1 uc334fsq.1 
ENSMUST00000295811.1 ENSMUSG00000129794 ENSMUST00000295811.1 ENSMUSG00000129794 (from geneSymbol) uc334fss.1 uc334fss.1 
ENSMUST00000295820.1 D430040L24Rik ENSMUST00000295820.1 D430040L24Rik (from geneSymbol) uc334ftb.1 uc334ftb.1 
ENSMUST00000295832.1 ENSMUSG00000129795 ENSMUST00000295832.1 ENSMUSG00000129795 (from geneSymbol) uc334ftn.1 uc334ftn.1 
ENSMUST00000295834.1 ENSMUSG00000129796 ENSMUST00000295834.1 ENSMUSG00000129796 (from geneSymbol) uc334ftp.1 uc334ftp.1 
ENSMUST00000295850.1 ENSMUSG00000129797 ENSMUST00000295850.1 ENSMUSG00000129797 (from geneSymbol) uc334fuf.1 uc334fuf.1 
ENSMUST00000295851.1 ENSMUSG00000129798 ENSMUST00000295851.1 ENSMUSG00000129798 (from geneSymbol) uc334fug.1 uc334fug.1 
ENSMUST00000295852.1 ENSMUSG00000129799 ENSMUST00000295852.1 ENSMUSG00000129799 (from geneSymbol) uc334fuh.1 uc334fuh.1 
ENSMUST00000295853.1 ENSMUSG00000129800 ENSMUST00000295853.1 ENSMUSG00000129800 (from geneSymbol) uc334fui.1 uc334fui.1 
ENSMUST00000295874.1 ENSMUSG00000129801 ENSMUST00000295874.1 ENSMUSG00000129801 (from geneSymbol) uc334fvd.1 uc334fvd.1 
ENSMUST00000295879.1 ENSMUSG00000129802 ENSMUST00000295879.1 ENSMUSG00000129802 (from geneSymbol) uc334fvi.1 uc334fvi.1 
ENSMUST00000295882.1 Gm28836 ENSMUST00000295882.1 Gm28836 (from geneSymbol) uc334fvl.1 uc334fvl.1 
ENSMUST00000295897.1 ENSMUSG00000129803 ENSMUST00000295897.1 ENSMUSG00000129803 (from geneSymbol) uc334fwa.1 uc334fwa.1 
ENSMUST00000295898.1 ENSMUSG00000129804 ENSMUST00000295898.1 ENSMUSG00000129804 (from geneSymbol) uc334fwb.1 uc334fwb.1 
ENSMUST00000295907.1 8430419K02Rik ENSMUST00000295907.1 8430419K02Rik (from geneSymbol) AK018427 uc334fwk.1 uc334fwk.1 
ENSMUST00000295928.1 ENSMUSG00000129805 ENSMUST00000295928.1 ENSMUSG00000129805 (from geneSymbol) uc334fxf.1 uc334fxf.1 
ENSMUST00000295934.1 ENSMUSG00000129806 ENSMUST00000295934.1 ENSMUSG00000129806 (from geneSymbol) uc334fxl.1 uc334fxl.1 
ENSMUST00000295935.1 4930470P17Rik ENSMUST00000295935.1 4930470P17Rik (from geneSymbol) AK015542 uc334fxm.1 uc334fxm.1 
ENSMUST00000295952.1 Gm26936 ENSMUST00000295952.1 Gm26936 (from geneSymbol) AK076660 uc334fyd.1 uc334fyd.1 
ENSMUST00000295981.1 Gm42865 ENSMUST00000295981.1 Gm42865 (from geneSymbol) uc334fzg.1 uc334fzg.1 
ENSMUST00000296000.1 ENSMUSG00000129807 ENSMUST00000296000.1 ENSMUSG00000129807 (from geneSymbol) uc334fzz.1 uc334fzz.1 
ENSMUST00000296001.1 ENSMUSG00000129808 ENSMUST00000296001.1 ENSMUSG00000129808 (from geneSymbol) uc334gaa.1 uc334gaa.1 
ENSMUST00000296004.1 ENSMUSG00000129809 ENSMUST00000296004.1 ENSMUSG00000129809 (from geneSymbol) uc334gad.1 uc334gad.1 
ENSMUST00000296007.1 Gm13261 ENSMUST00000296007.1 Gm13261 (from geneSymbol) AK076687 uc334gag.1 uc334gag.1 
ENSMUST00000296027.1 ENSMUSG00000129810 ENSMUST00000296027.1 ENSMUSG00000129810 (from geneSymbol) uc334gba.1 uc334gba.1 
ENSMUST00000296034.1 Gm34095 ENSMUST00000296034.1 Gm34095 (from geneSymbol) uc334gbh.1 uc334gbh.1 
ENSMUST00000296049.1 1700119I11Rik ENSMUST00000296049.1 1700119I11Rik (from geneSymbol) AK018965 uc334gbw.1 uc334gbw.1 
ENSMUST00000296058.1 1700019F05Rik ENSMUST00000296058.1 1700019F05Rik (from geneSymbol) AK006117 uc334gcf.1 uc334gcf.1 
ENSMUST00000296062.1 ENSMUSG00000129811 ENSMUST00000296062.1 ENSMUSG00000129811 (from geneSymbol) uc334gcj.1 uc334gcj.1 
ENSMUST00000296069.1 ENSMUSG00000129812 ENSMUST00000296069.1 ENSMUSG00000129812 (from geneSymbol) uc334gcq.1 uc334gcq.1 
ENSMUST00000296070.1 ENSMUSG00000129813 ENSMUST00000296070.1 ENSMUSG00000129813 (from geneSymbol) uc334gcr.1 uc334gcr.1 
ENSMUST00000296073.1 ENSMUSG00000129814 ENSMUST00000296073.1 ENSMUSG00000129814 (from geneSymbol) uc334gcu.1 uc334gcu.1 
ENSMUST00000296076.1 ENSMUSG00000129815 ENSMUST00000296076.1 ENSMUSG00000129815 (from geneSymbol) uc334gcx.1 uc334gcx.1 
ENSMUST00000296078.1 ENSMUSG00000129816 ENSMUST00000296078.1 ENSMUSG00000129816 (from geneSymbol) uc334gcz.1 uc334gcz.1 
ENSMUST00000296083.1 ENSMUSG00000129817 ENSMUST00000296083.1 ENSMUSG00000129817 (from geneSymbol) uc334gde.1 uc334gde.1 
ENSMUST00000296084.1 ENSMUSG00000129818 ENSMUST00000296084.1 ENSMUSG00000129818 (from geneSymbol) uc334gdf.1 uc334gdf.1 
ENSMUST00000296085.1 ENSMUSG00000129819 ENSMUST00000296085.1 ENSMUSG00000129819 (from geneSymbol) uc334gdg.1 uc334gdg.1 
ENSMUST00000296086.1 ENSMUSG00000129820 ENSMUST00000296086.1 ENSMUSG00000129820 (from geneSymbol) uc334gdh.1 uc334gdh.1 
ENSMUST00000296087.1 ENSMUSG00000129821 ENSMUST00000296087.1 ENSMUSG00000129821 (from geneSymbol) uc334gdi.1 uc334gdi.1 
ENSMUST00000296090.1 ENSMUSG00000129822 ENSMUST00000296090.1 ENSMUSG00000129822 (from geneSymbol) uc334gdl.1 uc334gdl.1 
ENSMUST00000296091.1 ENSMUSG00000129823 ENSMUST00000296091.1 ENSMUSG00000129823 (from geneSymbol) uc334gdm.1 uc334gdm.1 
ENSMUST00000296092.1 ENSMUSG00000129824 ENSMUST00000296092.1 ENSMUSG00000129824 (from geneSymbol) uc334gdn.1 uc334gdn.1 
ENSMUST00000296097.1 Gm31253 ENSMUST00000296097.1 Gm31253 (from geneSymbol) uc334gdr.1 uc334gdr.1 
ENSMUST00000296110.1 ENSMUSG00000129826 ENSMUST00000296110.1 ENSMUSG00000129826 (from geneSymbol) uc334gee.1 uc334gee.1 
ENSMUST00000296113.1 ENSMUSG00000129827 ENSMUST00000296113.1 ENSMUSG00000129827 (from geneSymbol) uc334geh.1 uc334geh.1 
ENSMUST00000296115.1 ENSMUSG00000129828 ENSMUST00000296115.1 ENSMUSG00000129828 (from geneSymbol) LF195023 uc334gej.1 uc334gej.1 
ENSMUST00000296119.1 ENSMUSG00000129829 ENSMUST00000296119.1 ENSMUSG00000129829 (from geneSymbol) uc334gen.1 uc334gen.1 
ENSMUST00000296126.1 ENSMUSG00000129830 ENSMUST00000296126.1 ENSMUSG00000129830 (from geneSymbol) uc334geu.1 uc334geu.1 
ENSMUST00000296127.1 ENSMUSG00000129831 ENSMUST00000296127.1 ENSMUSG00000129831 (from geneSymbol) uc334gev.1 uc334gev.1 
ENSMUST00000296128.1 ENSMUSG00000129832 ENSMUST00000296128.1 ENSMUSG00000129832 (from geneSymbol) uc334gew.1 uc334gew.1 
ENSMUST00000296146.1 ENSMUSG00000129833 ENSMUST00000296146.1 ENSMUSG00000129833 (from geneSymbol) uc334gfo.1 uc334gfo.1 
ENSMUST00000296157.1 ENSMUSG00000129834 ENSMUST00000296157.1 ENSMUSG00000129834 (from geneSymbol) uc334gfz.1 uc334gfz.1 
ENSMUST00000296159.1 Lhx5as1 ENSMUST00000296159.1 Lhx5as1 (from geneSymbol) uc334ggb.1 uc334ggb.1 
ENSMUST00000296188.1 ENSMUSG00000129835 ENSMUST00000296188.1 ENSMUSG00000129835 (from geneSymbol) uc334ghe.1 uc334ghe.1 
ENSMUST00000296189.1 ENSMUSG00000129836 ENSMUST00000296189.1 ENSMUSG00000129836 (from geneSymbol) uc334ghf.1 uc334ghf.1 
ENSMUST00000296191.1 ENSMUSG00000129837 ENSMUST00000296191.1 ENSMUSG00000129837 (from geneSymbol) uc334ghh.1 uc334ghh.1 
ENSMUST00000296193.1 ENSMUSG00000129838 ENSMUST00000296193.1 ENSMUSG00000129838 (from geneSymbol) AK041142 uc334ghj.1 uc334ghj.1 
ENSMUST00000296198.1 ENSMUSG00000129839 ENSMUST00000296198.1 ENSMUSG00000129839 (from geneSymbol) uc334gho.1 uc334gho.1 
ENSMUST00000296200.1 ENSMUSG00000129840 ENSMUST00000296200.1 ENSMUSG00000129840 (from geneSymbol) AK138554 uc334ghq.1 uc334ghq.1 
ENSMUST00000296207.1 ENSMUSG00000129841 ENSMUST00000296207.1 ENSMUSG00000129841 (from geneSymbol) uc334ghx.1 uc334ghx.1 
ENSMUST00000296208.1 ENSMUSG00000129842 ENSMUST00000296208.1 ENSMUSG00000129842 (from geneSymbol) uc334ghy.1 uc334ghy.1 
ENSMUST00000296210.1 ENSMUSG00000129843 ENSMUST00000296210.1 ENSMUSG00000129843 (from geneSymbol) uc334gia.1 uc334gia.1 
ENSMUST00000296211.1 ENSMUSG00000129844 ENSMUST00000296211.1 ENSMUSG00000129844 (from geneSymbol) uc334gib.1 uc334gib.1 
ENSMUST00000296213.1 ENSMUSG00000129845 ENSMUST00000296213.1 ENSMUSG00000129845 (from geneSymbol) uc334gid.1 uc334gid.1 
ENSMUST00000296215.1 Gm40770 ENSMUST00000296215.1 Gm40770 (from geneSymbol) uc334gif.1 uc334gif.1 
ENSMUST00000296252.1 4933433G15Rik ENSMUST00000296252.1 4933433G15Rik (from geneSymbol) AK017040 uc334gjq.1 uc334gjq.1 
ENSMUST00000296287.1 Gm14637 ENSMUST00000296287.1 Gm14637 (from geneSymbol) uc334gkz.1 uc334gkz.1 
ENSMUST00000296298.1 ENSMUSG00000129846 ENSMUST00000296298.1 ENSMUSG00000129846 (from geneSymbol) uc334glk.1 uc334glk.1 
ENSMUST00000296730.1 ENSMUSG00000129847 ENSMUST00000296730.1 ENSMUSG00000129847 (from geneSymbol) AK037803 uc334hbw.1 uc334hbw.1 
ENSMUST00000296731.1 ENSMUSG00000129848 ENSMUST00000296731.1 ENSMUSG00000129848 (from geneSymbol) uc334hbx.1 uc334hbx.1 
ENSMUST00000296738.1 ENSMUSG00000129849 ENSMUST00000296738.1 ENSMUSG00000129849 (from geneSymbol) uc334hce.1 uc334hce.1 
ENSMUST00000296740.1 Gm17115 ENSMUST00000296740.1 Gm17115 (from geneSymbol) AK085908 uc334hcg.1 uc334hcg.1 
ENSMUST00000296744.1 ENSMUSG00000129850 ENSMUST00000296744.1 ENSMUSG00000129850 (from geneSymbol) uc334hck.1 uc334hck.1 
ENSMUST00000296745.1 ENSMUSG00000129851 ENSMUST00000296745.1 ENSMUSG00000129851 (from geneSymbol) uc334hcl.1 uc334hcl.1 
ENSMUST00000296748.1 ENSMUSG00000129852 ENSMUST00000296748.1 ENSMUSG00000129852 (from geneSymbol) uc334hco.1 uc334hco.1 
ENSMUST00000296750.1 ENSMUSG00000129853 ENSMUST00000296750.1 ENSMUSG00000129853 (from geneSymbol) uc334hcq.1 uc334hcq.1 
ENSMUST00000296751.1 ENSMUSG00000129854 ENSMUST00000296751.1 ENSMUSG00000129854 (from geneSymbol) uc334hcr.1 uc334hcr.1 
ENSMUST00000296755.1 ENSMUSG00000129855 ENSMUST00000296755.1 ENSMUSG00000129855 (from geneSymbol) uc334hcv.1 uc334hcv.1 
ENSMUST00000296759.1 ENSMUSG00000129856 ENSMUST00000296759.1 ENSMUSG00000129856 (from geneSymbol) uc334hcz.1 uc334hcz.1 
ENSMUST00000296760.1 ENSMUSG00000129857 ENSMUST00000296760.1 ENSMUSG00000129857 (from geneSymbol) uc334hda.1 uc334hda.1 
ENSMUST00000296762.1 ENSMUSG00000129859 ENSMUST00000296762.1 ENSMUSG00000129859 (from geneSymbol) uc334hdb.1 uc334hdb.1 
ENSMUST00000296763.1 ENSMUSG00000129860 ENSMUST00000296763.1 ENSMUSG00000129860 (from geneSymbol) uc334hdc.1 uc334hdc.1 
ENSMUST00000296765.1 ENSMUSG00000129861 ENSMUST00000296765.1 ENSMUSG00000129861 (from geneSymbol) uc334hde.1 uc334hde.1 
ENSMUST00000296768.1 ENSMUSG00000129862 ENSMUST00000296768.1 ENSMUSG00000129862 (from geneSymbol) uc334hdh.1 uc334hdh.1 
ENSMUST00000296769.1 ENSMUSG00000129863 ENSMUST00000296769.1 ENSMUSG00000129863 (from geneSymbol) uc334hdi.1 uc334hdi.1 
ENSMUST00000296774.1 ENSMUSG00000129865 ENSMUST00000296774.1 ENSMUSG00000129865 (from geneSymbol) uc334hdm.1 uc334hdm.1 
ENSMUST00000296775.1 ENSMUSG00000129866 ENSMUST00000296775.1 ENSMUSG00000129866 (from geneSymbol) uc334hdn.1 uc334hdn.1 
ENSMUST00000296776.1 ENSMUSG00000129867 ENSMUST00000296776.1 ENSMUSG00000129867 (from geneSymbol) uc334hdo.1 uc334hdo.1 
ENSMUST00000296778.1 ENSMUSG00000129868 ENSMUST00000296778.1 ENSMUSG00000129868 (from geneSymbol) uc334hdq.1 uc334hdq.1 
ENSMUST00000296779.1 ENSMUSG00000129869 ENSMUST00000296779.1 ENSMUSG00000129869 (from geneSymbol) uc334hdr.1 uc334hdr.1 
ENSMUST00000296781.1 ENSMUSG00000129870 ENSMUST00000296781.1 ENSMUSG00000129870 (from geneSymbol) uc334hdt.1 uc334hdt.1 
ENSMUST00000296789.1 ENSMUSG00000129871 ENSMUST00000296789.1 ENSMUSG00000129871 (from geneSymbol) uc334heb.1 uc334heb.1 
ENSMUST00000296790.1 ENSMUSG00000129872 ENSMUST00000296790.1 ENSMUSG00000129872 (from geneSymbol) uc334hec.1 uc334hec.1 
ENSMUST00000296792.1 ENSMUSG00000129873 ENSMUST00000296792.1 ENSMUSG00000129873 (from geneSymbol) uc334hee.1 uc334hee.1 
ENSMUST00000296794.1 ENSMUSG00000129874 ENSMUST00000296794.1 ENSMUSG00000129874 (from geneSymbol) uc334heg.1 uc334heg.1 
ENSMUST00000296809.1 ENSMUSG00000129875 ENSMUST00000296809.1 ENSMUSG00000129875 (from geneSymbol) LF196759 uc334hev.1 uc334hev.1 
ENSMUST00000296810.1 ENSMUSG00000129876 ENSMUST00000296810.1 ENSMUSG00000129876 (from geneSymbol) uc334hew.1 uc334hew.1 
ENSMUST00000296811.1 ENSMUSG00000129877 ENSMUST00000296811.1 ENSMUSG00000129877 (from geneSymbol) uc334hex.1 uc334hex.1 
ENSMUST00000296812.1 ENSMUSG00000129878 ENSMUST00000296812.1 ENSMUSG00000129878 (from geneSymbol) uc334hey.1 uc334hey.1 
ENSMUST00000296814.1 ENSMUSG00000129879 ENSMUST00000296814.1 ENSMUSG00000129879 (from geneSymbol) uc334hfa.1 uc334hfa.1 
ENSMUST00000296819.1 ENSMUSG00000129880 ENSMUST00000296819.1 ENSMUSG00000129880 (from geneSymbol) uc334hff.1 uc334hff.1 
ENSMUST00000296820.1 ENSMUSG00000129881 ENSMUST00000296820.1 ENSMUSG00000129881 (from geneSymbol) uc334hfg.1 uc334hfg.1 
ENSMUST00000296821.1 ENSMUSG00000129882 ENSMUST00000296821.1 ENSMUSG00000129882 (from geneSymbol) uc334hfh.1 uc334hfh.1 
ENSMUST00000296823.1 ENSMUSG00000129883 ENSMUST00000296823.1 ENSMUSG00000129883 (from geneSymbol) uc334hfj.1 uc334hfj.1 
ENSMUST00000296835.1 1700021N21Rik ENSMUST00000296835.1 1700021N21Rik (from geneSymbol) AK006224 uc334hfv.1 uc334hfv.1 
ENSMUST00000296850.1 ENSMUSG00000129884 ENSMUST00000296850.1 ENSMUSG00000129884 (from geneSymbol) uc334hgk.1 uc334hgk.1 
ENSMUST00000296851.1 ENSMUSG00000129885 ENSMUST00000296851.1 ENSMUSG00000129885 (from geneSymbol) uc334hgl.1 uc334hgl.1 
ENSMUST00000296856.1 ENSMUSG00000129887 ENSMUST00000296856.1 ENSMUSG00000129887 (from geneSymbol) uc334hgo.1 uc334hgo.1 
ENSMUST00000296860.1 Gm57064 ENSMUST00000296860.1 Gm57064 (from geneSymbol) uc334hgs.1 uc334hgs.1 
ENSMUST00000296885.1 Gm48903 ENSMUST00000296885.1 Gm48903 (from geneSymbol) uc334hhr.1 uc334hhr.1 
ENSMUST00000296891.1 ENSMUSG00000129888 ENSMUST00000296891.1 ENSMUSG00000129888 (from geneSymbol) uc334hhx.1 uc334hhx.1 
ENSMUST00000296892.1 ENSMUSG00000129889 ENSMUST00000296892.1 ENSMUSG00000129889 (from geneSymbol) uc334hhy.1 uc334hhy.1 
ENSMUST00000296895.1 ENSMUSG00000129890 ENSMUST00000296895.1 ENSMUSG00000129890 (from geneSymbol) uc334hib.1 uc334hib.1 
ENSMUST00000296899.1 ENSMUSG00000129891 ENSMUST00000296899.1 ENSMUSG00000129891 (from geneSymbol) uc334hif.1 uc334hif.1 
ENSMUST00000296900.1 ENSMUSG00000129892 ENSMUST00000296900.1 ENSMUSG00000129892 (from geneSymbol) uc334hig.1 uc334hig.1 
ENSMUST00000296901.1 ENSMUSG00000129893 ENSMUST00000296901.1 ENSMUSG00000129893 (from geneSymbol) uc334hih.1 uc334hih.1 
ENSMUST00000296902.1 ENSMUSG00000129894 ENSMUST00000296902.1 ENSMUSG00000129894 (from geneSymbol) uc334hii.1 uc334hii.1 
ENSMUST00000296903.1 ENSMUSG00000129895 ENSMUST00000296903.1 ENSMUSG00000129895 (from geneSymbol) uc334hij.1 uc334hij.1 
ENSMUST00000296905.1 ENSMUSG00000129896 ENSMUST00000296905.1 ENSMUSG00000129896 (from geneSymbol) uc334hil.1 uc334hil.1 
ENSMUST00000296906.1 4930587E11Rik ENSMUST00000296906.1 4930587E11Rik (from geneSymbol) AK016361 uc334him.1 uc334him.1 
ENSMUST00000296915.1 ENSMUSG00000129897 ENSMUST00000296915.1 ENSMUSG00000129897 (from geneSymbol) uc334hiv.1 uc334hiv.1 
ENSMUST00000296916.1 ENSMUSG00000129898 ENSMUST00000296916.1 ENSMUSG00000129898 (from geneSymbol) uc334hiw.1 uc334hiw.1 
ENSMUST00000296933.1 ENSMUSG00000129900 ENSMUST00000296933.1 ENSMUSG00000129900 (from geneSymbol) uc334hjm.1 uc334hjm.1 
ENSMUST00000296935.1 Gm19426 ENSMUST00000296935.1 Gm19426 (from geneSymbol) uc334hjo.1 uc334hjo.1 
ENSMUST00000296941.1 ENSMUSG00000129901 ENSMUST00000296941.1 ENSMUSG00000129901 (from geneSymbol) uc334hju.1 uc334hju.1 
ENSMUST00000296942.1 ENSMUSG00000129902 ENSMUST00000296942.1 ENSMUSG00000129902 (from geneSymbol) uc334hjv.1 uc334hjv.1 
ENSMUST00000296943.1 ENSMUSG00000129903 ENSMUST00000296943.1 ENSMUSG00000129903 (from geneSymbol) uc334hjw.1 uc334hjw.1 
ENSMUST00000296944.1 ENSMUSG00000129904 ENSMUST00000296944.1 ENSMUSG00000129904 (from geneSymbol) uc334hjx.1 uc334hjx.1 
ENSMUST00000296948.1 ENSMUSG00000129905 ENSMUST00000296948.1 ENSMUSG00000129905 (from geneSymbol) uc334hkb.1 uc334hkb.1 
ENSMUST00000296949.1 ENSMUSG00000129906 ENSMUST00000296949.1 ENSMUSG00000129906 (from geneSymbol) uc334hkc.1 uc334hkc.1 
ENSMUST00000296951.1 ENSMUSG00000129907 ENSMUST00000296951.1 ENSMUSG00000129907 (from geneSymbol) uc334hke.1 uc334hke.1 
ENSMUST00000296952.1 ENSMUSG00000129908 ENSMUST00000296952.1 ENSMUSG00000129908 (from geneSymbol) uc334hkf.1 uc334hkf.1 
ENSMUST00000296954.1 ENSMUSG00000129909 ENSMUST00000296954.1 ENSMUSG00000129909 (from geneSymbol) uc334hkh.1 uc334hkh.1 
ENSMUST00000296958.1 ENSMUSG00000129910 ENSMUST00000296958.1 ENSMUSG00000129910 (from geneSymbol) uc334hkl.1 uc334hkl.1 
ENSMUST00000296985.1 ENSMUSG00000129911 ENSMUST00000296985.1 ENSMUSG00000129911 (from geneSymbol) uc334hlm.1 uc334hlm.1 
ENSMUST00000296992.1 ENSMUSG00000129912 ENSMUST00000296992.1 ENSMUSG00000129912 (from geneSymbol) uc334hlt.1 uc334hlt.1 
ENSMUST00000296993.1 ENSMUSG00000129913 ENSMUST00000296993.1 ENSMUSG00000129913 (from geneSymbol) uc334hlu.1 uc334hlu.1 
ENSMUST00000297003.1 ENSMUSG00000129914 ENSMUST00000297003.1 ENSMUSG00000129914 (from geneSymbol) uc334hme.1 uc334hme.1 
ENSMUST00000297004.1 ENSMUSG00000129915 ENSMUST00000297004.1 ENSMUSG00000129915 (from geneSymbol) uc334hmf.1 uc334hmf.1 
ENSMUST00000297006.1 ENSMUSG00000129916 ENSMUST00000297006.1 ENSMUSG00000129916 (from geneSymbol) uc334hmh.1 uc334hmh.1 
ENSMUST00000297007.1 Gm26771 ENSMUST00000297007.1 Gm26771 (from geneSymbol) AK137033 uc334hmi.1 uc334hmi.1 
ENSMUST00000297017.1 ENSMUSG00000129917 ENSMUST00000297017.1 ENSMUSG00000129917 (from geneSymbol) uc334hms.1 uc334hms.1 
ENSMUST00000297018.1 AA623943 ENSMUST00000297018.1 AA623943 (from geneSymbol) uc334hmt.1 uc334hmt.1 
ENSMUST00000297022.1 ENSMUSG00000129919 ENSMUST00000297022.1 ENSMUSG00000129919 (from geneSymbol) uc334hmx.1 uc334hmx.1 
ENSMUST00000297026.1 ENSMUSG00000129920 ENSMUST00000297026.1 ENSMUSG00000129920 (from geneSymbol) uc334hnb.1 uc334hnb.1 
ENSMUST00000297036.1 ENSMUSG00000129921 ENSMUST00000297036.1 ENSMUSG00000129921 (from geneSymbol) uc334hnl.1 uc334hnl.1 
ENSMUST00000297037.1 ENSMUSG00000129922 ENSMUST00000297037.1 ENSMUSG00000129922 (from geneSymbol) uc334hnm.1 uc334hnm.1 
ENSMUST00000297040.1 ENSMUSG00000129923 ENSMUST00000297040.1 ENSMUSG00000129923 (from geneSymbol) uc334hnp.1 uc334hnp.1 
ENSMUST00000297041.1 ENSMUSG00000129924 ENSMUST00000297041.1 ENSMUSG00000129924 (from geneSymbol) uc334hnq.1 uc334hnq.1 
ENSMUST00000297044.1 ENSMUSG00000129925 ENSMUST00000297044.1 ENSMUSG00000129925 (from geneSymbol) uc334hnt.1 uc334hnt.1 
ENSMUST00000297051.1 ENSMUSG00000129926 ENSMUST00000297051.1 ENSMUSG00000129926 (from geneSymbol) uc334hoa.1 uc334hoa.1 
ENSMUST00000297052.1 ENSMUSG00000129927 ENSMUST00000297052.1 ENSMUSG00000129927 (from geneSymbol) uc334hob.1 uc334hob.1 
ENSMUST00000297056.1 ENSMUSG00000129928 ENSMUST00000297056.1 ENSMUSG00000129928 (from geneSymbol) uc334hof.1 uc334hof.1 
ENSMUST00000297075.1 ENSMUSG00000129929 ENSMUST00000297075.1 ENSMUSG00000129929 (from geneSymbol) uc334hoy.1 uc334hoy.1 
ENSMUST00000297086.1 ENSMUSG00000129930 ENSMUST00000297086.1 ENSMUSG00000129930 (from geneSymbol) uc334hpj.1 uc334hpj.1 
ENSMUST00000297092.1 Gm40348 ENSMUST00000297092.1 Gm40348 (from geneSymbol) uc334hpp.1 uc334hpp.1 
ENSMUST00000297127.1 ENSMUSG00000129931 ENSMUST00000297127.1 ENSMUSG00000129931 (from geneSymbol) LF194148 uc334hqy.1 uc334hqy.1 
ENSMUST00000297129.1 Gm56955 ENSMUST00000297129.1 Gm56955 (from geneSymbol) uc334hra.1 uc334hra.1 
ENSMUST00000297142.1 Gm21316 ENSMUST00000297142.1 Gm21316 (from geneSymbol) BC089467 uc334hrn.1 uc334hrn.1 
ENSMUST00000297143.1 ENSMUSG00000129933 ENSMUST00000297143.1 ENSMUSG00000129933 (from geneSymbol) uc334hro.1 uc334hro.1 
ENSMUST00000297145.1 Gm20675 ENSMUST00000297145.1 Gm20675 (from geneSymbol) uc334hrq.1 uc334hrq.1 
ENSMUST00000297150.1 ENSMUSG00000129934 ENSMUST00000297150.1 ENSMUSG00000129934 (from geneSymbol) uc334hrv.1 uc334hrv.1 
ENSMUST00000297153.1 ENSMUSG00000129935 ENSMUST00000297153.1 ENSMUSG00000129935 (from geneSymbol) uc334hry.1 uc334hry.1 
ENSMUST00000297154.1 ENSMUSG00000129936 ENSMUST00000297154.1 ENSMUSG00000129936 (from geneSymbol) uc334hrz.1 uc334hrz.1 
ENSMUST00000297156.1 Gm31583 ENSMUST00000297156.1 Gm31583 (from geneSymbol) AK149396 uc334hsb.1 uc334hsb.1 
ENSMUST00000297228.1 ENSMUSG00000129937 ENSMUST00000297228.1 ENSMUSG00000129937 (from geneSymbol) uc334huu.1 uc334huu.1 
ENSMUST00000297236.1 ENSMUSG00000129938 ENSMUST00000297236.1 ENSMUSG00000129938 (from geneSymbol) uc334hvc.1 uc334hvc.1 
ENSMUST00000297239.1 ENSMUSG00000129939 ENSMUST00000297239.1 ENSMUSG00000129939 (from geneSymbol) uc334hvf.1 uc334hvf.1 
ENSMUST00000297245.1 Gm4219 ENSMUST00000297245.1 Gm4219 (from geneSymbol) AK143957 uc334hvl.1 uc334hvl.1 
ENSMUST00000297253.1 ENSMUSG00000129940 ENSMUST00000297253.1 ENSMUSG00000129940 (from geneSymbol) uc334hvt.1 uc334hvt.1 
ENSMUST00000297254.1 ENSMUSG00000129941 ENSMUST00000297254.1 ENSMUSG00000129941 (from geneSymbol) uc334hvu.1 uc334hvu.1 
ENSMUST00000297255.1 4933406I18Rik ENSMUST00000297255.1 4933406I18Rik (from geneSymbol) AK016693 uc334hvv.1 uc334hvv.1 
ENSMUST00000297272.1 ENSMUSG00000129942 ENSMUST00000297272.1 ENSMUSG00000129942 (from geneSymbol) uc334hwm.1 uc334hwm.1 
ENSMUST00000297273.1 ENSMUSG00000129943 ENSMUST00000297273.1 ENSMUSG00000129943 (from geneSymbol) uc334hwn.1 uc334hwn.1 
ENSMUST00000297278.1 ENSMUSG00000129944 ENSMUST00000297278.1 ENSMUSG00000129944 (from geneSymbol) uc334hws.1 uc334hws.1 
ENSMUST00000297279.1 ENSMUSG00000129945 ENSMUST00000297279.1 ENSMUSG00000129945 (from geneSymbol) uc334hwt.1 uc334hwt.1 
ENSMUST00000297280.1 ENSMUSG00000129946 ENSMUST00000297280.1 ENSMUSG00000129946 (from geneSymbol) uc334hwu.1 uc334hwu.1 
ENSMUST00000297285.1 ENSMUSG00000129947 ENSMUST00000297285.1 ENSMUSG00000129947 (from geneSymbol) uc334hwz.1 uc334hwz.1 
ENSMUST00000297286.1 ENSMUSG00000129948 ENSMUST00000297286.1 ENSMUSG00000129948 (from geneSymbol) uc334hxa.1 uc334hxa.1 
ENSMUST00000297288.1 ENSMUSG00000129949 ENSMUST00000297288.1 ENSMUSG00000129949 (from geneSymbol) uc334hxc.1 uc334hxc.1 
ENSMUST00000297291.1 ENSMUSG00000129950 ENSMUST00000297291.1 ENSMUSG00000129950 (from geneSymbol) uc334hxf.1 uc334hxf.1 
ENSMUST00000297292.1 ENSMUSG00000129951 ENSMUST00000297292.1 ENSMUSG00000129951 (from geneSymbol) uc334hxg.1 uc334hxg.1 
ENSMUST00000297293.1 ENSMUSG00000129952 ENSMUST00000297293.1 ENSMUSG00000129952 (from geneSymbol) uc334hxh.1 uc334hxh.1 
ENSMUST00000297299.1 ENSMUSG00000129953 ENSMUST00000297299.1 ENSMUSG00000129953 (from geneSymbol) uc334hxn.1 uc334hxn.1 
ENSMUST00000297300.1 ENSMUSG00000129954 ENSMUST00000297300.1 ENSMUSG00000129954 (from geneSymbol) AK140699 uc334hxo.1 uc334hxo.1 
ENSMUST00000297301.1 ENSMUSG00000129955 ENSMUST00000297301.1 ENSMUSG00000129955 (from geneSymbol) uc334hxp.1 uc334hxp.1 
ENSMUST00000297302.1 ENSMUSG00000129956 ENSMUST00000297302.1 ENSMUSG00000129956 (from geneSymbol) uc334hxq.1 uc334hxq.1 
ENSMUST00000297303.1 ENSMUSG00000129957 ENSMUST00000297303.1 ENSMUSG00000129957 (from geneSymbol) uc334hxr.1 uc334hxr.1 
ENSMUST00000297305.1 ENSMUSG00000129958 ENSMUST00000297305.1 ENSMUSG00000129958 (from geneSymbol) uc334hxt.1 uc334hxt.1 
ENSMUST00000297306.1 ENSMUSG00000129959 ENSMUST00000297306.1 ENSMUSG00000129959 (from geneSymbol) uc334hxu.1 uc334hxu.1 
ENSMUST00000297309.1 ENSMUSG00000129960 ENSMUST00000297309.1 ENSMUSG00000129960 (from geneSymbol) uc334hxx.1 uc334hxx.1 
ENSMUST00000297311.1 ENSMUSG00000129961 ENSMUST00000297311.1 ENSMUSG00000129961 (from geneSymbol) uc334hxz.1 uc334hxz.1 
ENSMUST00000297323.1 ENSMUSG00000129962 ENSMUST00000297323.1 ENSMUSG00000129962 (from geneSymbol) uc334hyl.1 uc334hyl.1 
ENSMUST00000297325.1 ENSMUSG00000129963 ENSMUST00000297325.1 ENSMUSG00000129963 (from geneSymbol) uc334hyn.1 uc334hyn.1 
ENSMUST00000297326.1 ENSMUSG00000129964 ENSMUST00000297326.1 ENSMUSG00000129964 (from geneSymbol) uc334hyo.1 uc334hyo.1 
ENSMUST00000297331.1 Gm34590 ENSMUST00000297331.1 Gm34590 (from geneSymbol) uc334hyt.1 uc334hyt.1 
ENSMUST00000297374.1 ENSMUSG00000129965 ENSMUST00000297374.1 ENSMUSG00000129965 (from geneSymbol) uc334iaj.1 uc334iaj.1 
ENSMUST00000297375.1 ENSMUSG00000129966 ENSMUST00000297375.1 ENSMUSG00000129966 (from geneSymbol) uc334iak.1 uc334iak.1 
ENSMUST00000297377.1 ENSMUSG00000129967 ENSMUST00000297377.1 ENSMUSG00000129967 (from geneSymbol) uc334iam.1 uc334iam.1 
ENSMUST00000297378.1 ENSMUSG00000129968 ENSMUST00000297378.1 ENSMUSG00000129968 (from geneSymbol) uc334ian.1 uc334ian.1 
ENSMUST00000297392.1 ENSMUSG00000129969 ENSMUST00000297392.1 ENSMUSG00000129969 (from geneSymbol) uc334ibb.1 uc334ibb.1 
ENSMUST00000297402.1 Gm36099 ENSMUST00000297402.1 Gm36099 (from geneSymbol) AK133076 uc334ibl.1 uc334ibl.1 
ENSMUST00000297411.1 ENSMUSG00000129970 ENSMUST00000297411.1 ENSMUSG00000129970 (from geneSymbol) uc334ibu.1 uc334ibu.1 
ENSMUST00000297412.1 ENSMUSG00000129971 ENSMUST00000297412.1 ENSMUSG00000129971 (from geneSymbol) uc334ibv.1 uc334ibv.1 
ENSMUST00000297413.1 ENSMUSG00000129972 ENSMUST00000297413.1 ENSMUSG00000129972 (from geneSymbol) uc334ibw.1 uc334ibw.1 
ENSMUST00000297414.1 ENSMUSG00000129973 ENSMUST00000297414.1 ENSMUSG00000129973 (from geneSymbol) uc334ibx.1 uc334ibx.1 
ENSMUST00000297415.1 ENSMUSG00000129974 ENSMUST00000297415.1 ENSMUSG00000129974 (from geneSymbol) uc334iby.1 uc334iby.1 
ENSMUST00000297417.1 ENSMUSG00000129975 ENSMUST00000297417.1 ENSMUSG00000129975 (from geneSymbol) U34827 uc334ica.1 uc334ica.1 
ENSMUST00000297418.1 ENSMUSG00000129976 ENSMUST00000297418.1 ENSMUSG00000129976 (from geneSymbol) uc334icb.1 uc334icb.1 
ENSMUST00000297419.1 ENSMUSG00000129977 ENSMUST00000297419.1 ENSMUSG00000129977 (from geneSymbol) uc334icc.1 uc334icc.1 
ENSMUST00000297420.1 ENSMUSG00000129978 ENSMUST00000297420.1 ENSMUSG00000129978 (from geneSymbol) uc334icd.1 uc334icd.1 
ENSMUST00000297422.1 ENSMUSG00000129979 ENSMUST00000297422.1 ENSMUSG00000129979 (from geneSymbol) uc334icf.1 uc334icf.1 
ENSMUST00000297423.1 ENSMUSG00000129980 ENSMUST00000297423.1 ENSMUSG00000129980 (from geneSymbol) uc334icg.1 uc334icg.1 
ENSMUST00000297424.1 ENSMUSG00000129981 ENSMUST00000297424.1 ENSMUSG00000129981 (from geneSymbol) uc334ich.1 uc334ich.1 
ENSMUST00000297425.1 ENSMUSG00000129982 ENSMUST00000297425.1 ENSMUSG00000129982 (from geneSymbol) uc334ici.1 uc334ici.1 
ENSMUST00000297429.1 ENSMUSG00000129983 ENSMUST00000297429.1 ENSMUSG00000129983 (from geneSymbol) uc334icm.1 uc334icm.1 
ENSMUST00000297432.1 Gm33667 ENSMUST00000297432.1 Gm33667 (from geneSymbol) uc334icp.1 uc334icp.1 
ENSMUST00000297434.1 ENSMUSG00000129984 ENSMUST00000297434.1 ENSMUSG00000129984 (from geneSymbol) uc334icr.1 uc334icr.1 
ENSMUST00000297444.1 ENSMUSG00000129985 ENSMUST00000297444.1 ENSMUSG00000129985 (from geneSymbol) uc334idb.1 uc334idb.1 
ENSMUST00000297446.1 ENSMUSG00000129986 ENSMUST00000297446.1 ENSMUSG00000129986 (from geneSymbol) uc334idd.1 uc334idd.1 
ENSMUST00000297447.1 ENSMUSG00000129987 ENSMUST00000297447.1 ENSMUSG00000129987 (from geneSymbol) uc334ide.1 uc334ide.1 
ENSMUST00000297455.1 ENSMUSG00000129988 ENSMUST00000297455.1 ENSMUSG00000129988 (from geneSymbol) uc334idm.1 uc334idm.1 
ENSMUST00000297458.1 ENSMUSG00000129989 ENSMUST00000297458.1 ENSMUSG00000129989 (from geneSymbol) uc334idp.1 uc334idp.1 
ENSMUST00000297460.1 ENSMUSG00000129990 ENSMUST00000297460.1 ENSMUSG00000129990 (from geneSymbol) uc334idr.1 uc334idr.1 
ENSMUST00000297461.1 ENSMUSG00000129991 ENSMUST00000297461.1 predicted gene, 38958 (from RefSeq NR_164195.1) NR_164195 uc334ids.1 uc334ids.1 
ENSMUST00000297462.1 ENSMUSG00000129992 ENSMUST00000297462.1 ENSMUSG00000129992 (from geneSymbol) uc334idt.1 uc334idt.1 
ENSMUST00000297463.1 ENSMUSG00000129993 ENSMUST00000297463.1 ENSMUSG00000129993 (from geneSymbol) uc334idu.1 uc334idu.1 
ENSMUST00000297468.1 4930543I03Rik ENSMUST00000297468.1 4930543I03Rik (from geneSymbol) AK016029 uc334idz.1 uc334idz.1 
ENSMUST00000297504.1 ENSMUSG00000129994 ENSMUST00000297504.1 ENSMUSG00000129994 (from geneSymbol) uc334ifj.1 uc334ifj.1 
ENSMUST00000297505.1 ENSMUSG00000129995 ENSMUST00000297505.1 ENSMUSG00000129995 (from geneSymbol) uc334ifk.1 uc334ifk.1 
ENSMUST00000297506.1 ENSMUSG00000129996 ENSMUST00000297506.1 ENSMUSG00000129996 (from geneSymbol) uc334ifl.1 uc334ifl.1 
ENSMUST00000297509.1 ENSMUSG00000129997 ENSMUST00000297509.1 ENSMUSG00000129997 (from geneSymbol) uc334ifo.1 uc334ifo.1 
ENSMUST00000297538.1 1700100I10Rik ENSMUST00000297538.1 1700100I10Rik (from geneSymbol) AK007006 uc334igr.1 uc334igr.1 
ENSMUST00000297563.1 ENSMUSG00000129998 ENSMUST00000297563.1 ENSMUSG00000129998 (from geneSymbol) uc334ihq.1 uc334ihq.1 
ENSMUST00000297564.1 ENSMUSG00000129999 ENSMUST00000297564.1 ENSMUSG00000129999 (from geneSymbol) uc334ihr.1 uc334ihr.1 
ENSMUST00000297565.1 ENSMUSG00000130000 ENSMUST00000297565.1 ENSMUSG00000130000 (from geneSymbol) uc334ihs.1 uc334ihs.1 
ENSMUST00000297566.1 ENSMUSG00000130001 ENSMUST00000297566.1 ENSMUSG00000130001 (from geneSymbol) uc334iht.1 uc334iht.1 
ENSMUST00000297580.1 ENSMUSG00000130002 ENSMUST00000297580.1 ENSMUSG00000130002 (from geneSymbol) uc334iih.1 uc334iih.1 
ENSMUST00000297590.1 ENSMUSG00000130003 ENSMUST00000297590.1 ENSMUSG00000130003 (from geneSymbol) uc334iir.1 uc334iir.1 
ENSMUST00000297592.1 ENSMUSG00000130004 ENSMUST00000297592.1 ENSMUSG00000130004 (from geneSymbol) uc334iit.1 uc334iit.1 
ENSMUST00000297593.1 ENSMUSG00000130005 ENSMUST00000297593.1 ENSMUSG00000130005 (from geneSymbol) uc334iiu.1 uc334iiu.1 
ENSMUST00000297597.1 ENSMUSG00000130006 ENSMUST00000297597.1 ENSMUSG00000130006 (from geneSymbol) uc334iiy.1 uc334iiy.1 
ENSMUST00000297600.1 ENSMUSG00000130007 ENSMUST00000297600.1 ENSMUSG00000130007 (from geneSymbol) uc334ijb.1 uc334ijb.1 
ENSMUST00000297602.1 ENSMUSG00000130008 ENSMUST00000297602.1 ENSMUSG00000130008 (from geneSymbol) uc334ijd.1 uc334ijd.1 
ENSMUST00000297603.1 Gm49688 ENSMUST00000297603.1 Gm49688 (from geneSymbol) uc334ije.1 uc334ije.1 
ENSMUST00000297616.1 ENSMUSG00000130009 ENSMUST00000297616.1 ENSMUSG00000130009 (from geneSymbol) uc334ijq.1 uc334ijq.1 
ENSMUST00000297617.1 ENSMUSG00000130010 ENSMUST00000297617.1 ENSMUSG00000130010 (from geneSymbol) uc334ijr.1 uc334ijr.1 
ENSMUST00000297619.1 ENSMUSG00000130011 ENSMUST00000297619.1 ENSMUSG00000130011 (from geneSymbol) uc334ijt.1 uc334ijt.1 
ENSMUST00000297620.1 ENSMUSG00000130012 ENSMUST00000297620.1 ENSMUSG00000130012 (from geneSymbol) uc334iju.1 uc334iju.1 
ENSMUST00000297622.1 ENSMUSG00000130013 ENSMUST00000297622.1 ENSMUSG00000130013 (from geneSymbol) uc334ijw.1 uc334ijw.1 
ENSMUST00000297632.1 Gm11465 ENSMUST00000297632.1 Gm11465 (from geneSymbol) KY467914 uc334ikg.1 uc334ikg.1 
ENSMUST00000297633.1 ENSMUSG00000130014 ENSMUST00000297633.1 ENSMUSG00000130014 (from geneSymbol) uc334ikh.1 uc334ikh.1 
ENSMUST00000297635.1 ENSMUSG00000130016 ENSMUST00000297635.1 ENSMUSG00000130016 (from geneSymbol) uc334iki.1 uc334iki.1 
ENSMUST00000297642.1 ENSMUSG00000130017 ENSMUST00000297642.1 ENSMUSG00000130017 (from geneSymbol) uc334ikp.1 uc334ikp.1 
ENSMUST00000297644.1 ENSMUSG00000130018 ENSMUST00000297644.1 ENSMUSG00000130018 (from geneSymbol) uc334ikr.1 uc334ikr.1 
ENSMUST00000297646.1 Fam219aos ENSMUST00000297646.1 Fam219aos (from geneSymbol) AK006904 uc334ikt.1 uc334ikt.1 
ENSMUST00000297648.1 ENSMUSG00000130019 ENSMUST00000297648.1 ENSMUSG00000130019 (from geneSymbol) uc334ikv.1 uc334ikv.1 
ENSMUST00000297657.1 ENSMUSG00000130020 ENSMUST00000297657.1 ENSMUSG00000130020 (from geneSymbol) uc334ile.1 uc334ile.1 
ENSMUST00000297674.1 Gm50416 ENSMUST00000297674.1 Gm50416 (from geneSymbol) uc334ilv.1 uc334ilv.1 
ENSMUST00000297682.1 ENSMUSG00000130021 ENSMUST00000297682.1 ENSMUSG00000130021 (from geneSymbol) uc334imd.1 uc334imd.1 
ENSMUST00000297683.1 ENSMUSG00000130022 ENSMUST00000297683.1 ENSMUSG00000130022 (from geneSymbol) uc334ime.1 uc334ime.1 
ENSMUST00000297684.1 ENSMUSG00000130023 ENSMUST00000297684.1 ENSMUSG00000130023 (from geneSymbol) uc334imf.1 uc334imf.1 
ENSMUST00000297697.1 ENSMUSG00000130024 ENSMUST00000297697.1 ENSMUSG00000130024 (from geneSymbol) uc334ims.1 uc334ims.1 
ENSMUST00000297699.1 ENSMUSG00000130025 ENSMUST00000297699.1 ENSMUSG00000130025 (from geneSymbol) uc334imu.1 uc334imu.1 
ENSMUST00000297701.1 ENSMUSG00000130026 ENSMUST00000297701.1 ENSMUSG00000130026 (from geneSymbol) uc334imw.1 uc334imw.1 
ENSMUST00000297703.1 Gm13538 ENSMUST00000297703.1 Gm13538 (from geneSymbol) uc334imy.1 uc334imy.1 
ENSMUST00000297716.1 ENSMUSG00000130027 ENSMUST00000297716.1 ENSMUSG00000130027 (from geneSymbol) uc334inl.1 uc334inl.1 
ENSMUST00000297777.1 ENSMUSG00000130028 ENSMUST00000297777.1 ENSMUSG00000130028 (from geneSymbol) uc334ipu.1 uc334ipu.1 
ENSMUST00000297786.1 ENSMUSG00000130029 ENSMUST00000297786.1 ENSMUSG00000130029 (from geneSymbol) uc334iqd.1 uc334iqd.1 
ENSMUST00000297788.1 ENSMUSG00000130030 ENSMUST00000297788.1 ENSMUSG00000130030 (from geneSymbol) uc334iqf.1 uc334iqf.1 
ENSMUST00000297791.1 ENSMUSG00000130031 ENSMUST00000297791.1 ENSMUSG00000130031 (from geneSymbol) uc334iqi.1 uc334iqi.1 
ENSMUST00000297793.1 ENSMUSG00000130032 ENSMUST00000297793.1 ENSMUSG00000130032 (from geneSymbol) uc334iqk.1 uc334iqk.1 
ENSMUST00000297794.1 ENSMUSG00000130033 ENSMUST00000297794.1 ENSMUSG00000130033 (from geneSymbol) uc334iql.1 uc334iql.1 
ENSMUST00000297795.1 ENSMUSG00000130034 ENSMUST00000297795.1 ENSMUSG00000130034 (from geneSymbol) uc334iqm.1 uc334iqm.1 
ENSMUST00000297815.1 ENSMUSG00000130035 ENSMUST00000297815.1 ENSMUSG00000130035 (from geneSymbol) uc334irg.1 uc334irg.1 
ENSMUST00000297833.1 ENSMUSG00000130036 ENSMUST00000297833.1 ENSMUSG00000130036 (from geneSymbol) uc334irx.1 uc334irx.1 
ENSMUST00000297835.1 ENSMUSG00000130037 ENSMUST00000297835.1 ENSMUSG00000130037 (from geneSymbol) uc334iry.1 uc334iry.1 
ENSMUST00000297836.1 Gm56521 ENSMUST00000297836.1 Gm56521 (from geneSymbol) uc334irz.1 uc334irz.1 
ENSMUST00000297840.1 ENSMUSG00000130038 ENSMUST00000297840.1 ENSMUSG00000130038 (from geneSymbol) uc334isd.1 uc334isd.1 
ENSMUST00000297849.1 ENSMUSG00000130039 ENSMUST00000297849.1 ENSMUSG00000130039 (from geneSymbol) uc334ism.1 uc334ism.1 
ENSMUST00000297852.1 ENSMUSG00000130040 ENSMUST00000297852.1 ENSMUSG00000130040 (from geneSymbol) uc334isp.1 uc334isp.1 
ENSMUST00000297868.1 ENSMUSG00000130041 ENSMUST00000297868.1 ENSMUSG00000130041 (from geneSymbol) uc334itf.1 uc334itf.1 
ENSMUST00000297869.1 ENSMUSG00000130042 ENSMUST00000297869.1 ENSMUSG00000130042 (from geneSymbol) uc334itg.1 uc334itg.1 
ENSMUST00000297871.1 ENSMUSG00000130043 ENSMUST00000297871.1 ENSMUSG00000130043 (from geneSymbol) uc334iti.1 uc334iti.1 
ENSMUST00000297874.1 ENSMUSG00000130044 ENSMUST00000297874.1 ENSMUSG00000130044 (from geneSymbol) uc334itl.1 uc334itl.1 
ENSMUST00000297875.1 ENSMUSG00000130045 ENSMUST00000297875.1 ENSMUSG00000130045 (from geneSymbol) uc334itm.1 uc334itm.1 
ENSMUST00000297877.1 ENSMUSG00000130046 ENSMUST00000297877.1 ENSMUSG00000130046 (from geneSymbol) uc334ito.1 uc334ito.1 
ENSMUST00000297878.1 Gm26590 ENSMUST00000297878.1 Gm26590 (from geneSymbol) AK146690 uc334itp.1 uc334itp.1 
ENSMUST00000297883.1 ENSMUSG00000130047 ENSMUST00000297883.1 ENSMUSG00000130047 (from geneSymbol) uc334itu.1 uc334itu.1 
ENSMUST00000297885.1 ENSMUSG00000130049 ENSMUST00000297885.1 ENSMUSG00000130049 (from geneSymbol) uc334itv.1 uc334itv.1 
ENSMUST00000297889.1 Gm56599 ENSMUST00000297889.1 Gm56599 (from geneSymbol) uc334ity.1 uc334ity.1 
ENSMUST00000297911.1 ENSMUSG00000130050 ENSMUST00000297911.1 ENSMUSG00000130050 (from geneSymbol) uc334iuu.1 uc334iuu.1 
ENSMUST00000297913.1 ENSMUSG00000130051 ENSMUST00000297913.1 ENSMUSG00000130051 (from geneSymbol) uc334iuw.1 uc334iuw.1 
ENSMUST00000297914.1 ENSMUSG00000130052 ENSMUST00000297914.1 ENSMUSG00000130052 (from geneSymbol) uc334iux.1 uc334iux.1 
ENSMUST00000297916.1 ENSMUSG00000130053 ENSMUST00000297916.1 ENSMUSG00000130053 (from geneSymbol) uc334iuz.1 uc334iuz.1 
ENSMUST00000297917.1 Gm41300 ENSMUST00000297917.1 Gm41300 (from geneSymbol) uc334iva.1 uc334iva.1 
ENSMUST00000297926.1 ENSMUSG00000130054 ENSMUST00000297926.1 ENSMUSG00000130054 (from geneSymbol) AK006623 uc334ivj.1 uc334ivj.1 
ENSMUST00000297927.1 ENSMUSG00000130055 ENSMUST00000297927.1 ENSMUSG00000130055 (from geneSymbol) uc334ivk.1 uc334ivk.1 
ENSMUST00000297939.1 Gm45096 ENSMUST00000297939.1 Gm45096 (from geneSymbol) uc334ivq.1 uc334ivq.1 
ENSMUST00000297942.1 ENSMUSG00000130057 ENSMUST00000297942.1 ENSMUSG00000130057 (from geneSymbol) uc334ivt.1 uc334ivt.1 
ENSMUST00000297945.1 ENSMUSG00000130058 ENSMUST00000297945.1 ENSMUSG00000130058 (from geneSymbol) uc334ivw.1 uc334ivw.1 
ENSMUST00000297947.1 ENSMUSG00000130059 ENSMUST00000297947.1 ENSMUSG00000130059 (from geneSymbol) uc334ivy.1 uc334ivy.1 
ENSMUST00000297965.1 ENSMUSG00000130060 ENSMUST00000297965.1 ENSMUSG00000130060 (from geneSymbol) uc334iwq.1 uc334iwq.1 
ENSMUST00000297975.1 ENSMUSG00000130061 ENSMUST00000297975.1 ENSMUSG00000130061 (from geneSymbol) uc334ixa.1 uc334ixa.1 
ENSMUST00000297986.1 ENSMUSG00000130062 ENSMUST00000297986.1 ENSMUSG00000130062 (from geneSymbol) uc334ixl.1 uc334ixl.1 
ENSMUST00000297988.1 ENSMUSG00000130063 ENSMUST00000297988.1 ENSMUSG00000130063 (from geneSymbol) uc334ixn.1 uc334ixn.1 
ENSMUST00000297990.1 ENSMUSG00000130064 ENSMUST00000297990.1 ENSMUSG00000130064 (from geneSymbol) uc334ixo.1 uc334ixo.1 
ENSMUST00000297996.1 Gm50415 ENSMUST00000297996.1 Gm50415 (from geneSymbol) AK082637 uc334ixr.1 uc334ixr.1 
ENSMUST00000297998.1 ENSMUSG00000130065 ENSMUST00000297998.1 ENSMUSG00000130065 (from geneSymbol) uc334ixt.1 uc334ixt.1 
ENSMUST00000297999.1 ENSMUSG00000130066 ENSMUST00000297999.1 ENSMUSG00000130066 (from geneSymbol) uc334ixu.1 uc334ixu.1 
ENSMUST00000298001.1 ENSMUSG00000130067 ENSMUST00000298001.1 ENSMUSG00000130067 (from geneSymbol) uc334ixw.1 uc334ixw.1 
ENSMUST00000298005.1 ENSMUSG00000130068 ENSMUST00000298005.1 ENSMUSG00000130068 (from geneSymbol) uc334iya.1 uc334iya.1 
ENSMUST00000298008.1 ENSMUSG00000130069 ENSMUST00000298008.1 ENSMUSG00000130069 (from geneSymbol) uc334iyd.1 uc334iyd.1 
ENSMUST00000298012.1 ENSMUSG00000130070 ENSMUST00000298012.1 ENSMUSG00000130070 (from geneSymbol) uc334iyh.1 uc334iyh.1 
ENSMUST00000298014.1 ENSMUSG00000130071 ENSMUST00000298014.1 ENSMUSG00000130071 (from geneSymbol) uc334iyj.1 uc334iyj.1 
ENSMUST00000298015.1 ENSMUSG00000130072 ENSMUST00000298015.1 ENSMUSG00000130072 (from geneSymbol) uc334iyk.1 uc334iyk.1 
ENSMUST00000298033.1 Gm56586 ENSMUST00000298033.1 Gm56586 (from geneSymbol) uc334izc.1 uc334izc.1 
ENSMUST00000298038.1 ENSMUSG00000130074 ENSMUST00000298038.1 ENSMUSG00000130074 (from geneSymbol) uc334izh.1 uc334izh.1 
ENSMUST00000298041.1 ENSMUSG00000130075 ENSMUST00000298041.1 ENSMUSG00000130075 (from geneSymbol) uc334izk.1 uc334izk.1 
ENSMUST00000298043.1 ENSMUSG00000130076 ENSMUST00000298043.1 ENSMUSG00000130076 (from geneSymbol) uc334izm.1 uc334izm.1 
ENSMUST00000298052.1 ENSMUSG00000130077 ENSMUST00000298052.1 ENSMUSG00000130077 (from geneSymbol) uc334izv.1 uc334izv.1 
ENSMUST00000298054.1 ENSMUSG00000130078 ENSMUST00000298054.1 ENSMUSG00000130078 (from geneSymbol) uc334izx.1 uc334izx.1 
ENSMUST00000298057.1 ENSMUSG00000130079 ENSMUST00000298057.1 ENSMUSG00000130079 (from geneSymbol) uc334jaa.1 uc334jaa.1 
ENSMUST00000298058.1 ENSMUSG00000130080 ENSMUST00000298058.1 ENSMUSG00000130080 (from geneSymbol) uc334jab.1 uc334jab.1 
ENSMUST00000298059.1 Gm56978 ENSMUST00000298059.1 Gm56978 (from geneSymbol) uc334jac.1 uc334jac.1 
ENSMUST00000298060.1 Gm45335 ENSMUST00000298060.1 Gm45335 (from geneSymbol) uc334jad.1 uc334jad.1 
ENSMUST00000298062.1 ENSMUSG00000130081 ENSMUST00000298062.1 ENSMUSG00000130081 (from geneSymbol) uc334jaf.1 uc334jaf.1 
ENSMUST00000298063.1 ENSMUSG00000130082 ENSMUST00000298063.1 ENSMUSG00000130082 (from geneSymbol) uc334jag.1 uc334jag.1 
ENSMUST00000298067.1 ENSMUSG00000130083 ENSMUST00000298067.1 ENSMUSG00000130083 (from geneSymbol) uc334jak.1 uc334jak.1 
ENSMUST00000298072.1 ENSMUSG00000130084 ENSMUST00000298072.1 ENSMUSG00000130084 (from geneSymbol) uc334jap.1 uc334jap.1 
ENSMUST00000298073.1 ENSMUSG00000130085 ENSMUST00000298073.1 ENSMUSG00000130085 (from geneSymbol) uc334jaq.1 uc334jaq.1 
ENSMUST00000298076.1 ENSMUSG00000130086 ENSMUST00000298076.1 ENSMUSG00000130086 (from geneSymbol) uc334jat.1 uc334jat.1 
ENSMUST00000298084.1 ENSMUSG00000130087 ENSMUST00000298084.1 ENSMUSG00000130087 (from geneSymbol) uc334jbb.1 uc334jbb.1 
ENSMUST00000298085.1 ENSMUSG00000130088 ENSMUST00000298085.1 ENSMUSG00000130088 (from geneSymbol) uc334jbc.1 uc334jbc.1 
ENSMUST00000298086.1 ENSMUSG00000130089 ENSMUST00000298086.1 ENSMUSG00000130089 (from geneSymbol) uc334jbd.1 uc334jbd.1 
ENSMUST00000298087.1 ENSMUSG00000130090 ENSMUST00000298087.1 ENSMUSG00000130090 (from geneSymbol) uc334jbe.1 uc334jbe.1 
ENSMUST00000298089.1 ENSMUSG00000130091 ENSMUST00000298089.1 ENSMUSG00000130091 (from geneSymbol) uc334jbg.1 uc334jbg.1 
ENSMUST00000298090.1 Gm13794 ENSMUST00000298090.1 Gm13794 (from geneSymbol) AK131712 uc334jbh.1 uc334jbh.1 
ENSMUST00000298092.1 ENSMUSG00000130092 ENSMUST00000298092.1 ENSMUSG00000130092 (from geneSymbol) uc334jbj.1 uc334jbj.1 
ENSMUST00000298094.1 ENSMUSG00000130093 ENSMUST00000298094.1 ENSMUSG00000130093 (from geneSymbol) uc334jbl.1 uc334jbl.1 
ENSMUST00000298098.1 ENSMUSG00000130094 ENSMUST00000298098.1 ENSMUSG00000130094 (from geneSymbol) uc334jbp.1 uc334jbp.1 
ENSMUST00000298099.1 ENSMUSG00000130095 ENSMUST00000298099.1 ENSMUSG00000130095 (from geneSymbol) uc334jbq.1 uc334jbq.1 
ENSMUST00000298104.1 ENSMUSG00000130096 ENSMUST00000298104.1 ENSMUSG00000130096 (from geneSymbol) uc334jbv.1 uc334jbv.1 
ENSMUST00000298117.1 ENSMUSG00000130097 ENSMUST00000298117.1 ENSMUSG00000130097 (from geneSymbol) uc334jci.1 uc334jci.1 
ENSMUST00000298118.1 ENSMUSG00000130098 ENSMUST00000298118.1 ENSMUSG00000130098 (from geneSymbol) AK154397 uc334jcj.1 uc334jcj.1 
ENSMUST00000298119.1 ENSMUSG00000130099 ENSMUST00000298119.1 ENSMUSG00000130099 (from geneSymbol) uc334jck.1 uc334jck.1 
ENSMUST00000298123.1 Gm56839 ENSMUST00000298123.1 Gm56839 (from geneSymbol) uc334jcn.1 uc334jcn.1 
ENSMUST00000298130.1 ENSMUSG00000130101 ENSMUST00000298130.1 ENSMUSG00000130101 (from geneSymbol) uc334jcu.1 uc334jcu.1 
ENSMUST00000298132.1 ENSMUSG00000130102 ENSMUST00000298132.1 ENSMUSG00000130102 (from geneSymbol) LF200646 uc334jcw.1 uc334jcw.1 
ENSMUST00000298133.1 ENSMUSG00000130103 ENSMUST00000298133.1 ENSMUSG00000130103 (from geneSymbol) uc334jcx.1 uc334jcx.1 
ENSMUST00000298140.1 ENSMUSG00000130104 ENSMUST00000298140.1 ENSMUSG00000130104 (from geneSymbol) uc334jde.1 uc334jde.1 
ENSMUST00000298141.1 ENSMUSG00000130105 ENSMUST00000298141.1 ENSMUSG00000130105 (from geneSymbol) uc334jdf.1 uc334jdf.1 
ENSMUST00000298145.1 ENSMUSG00000130106 ENSMUST00000298145.1 ENSMUSG00000130106 (from geneSymbol) uc334jdj.1 uc334jdj.1 
ENSMUST00000298146.1 ENSMUSG00000130107 ENSMUST00000298146.1 ENSMUSG00000130107 (from geneSymbol) uc334jdk.1 uc334jdk.1 
ENSMUST00000298156.1 ENSMUSG00000130108 ENSMUST00000298156.1 ENSMUSG00000130108 (from geneSymbol) uc334jdu.1 uc334jdu.1 
ENSMUST00000298157.1 ENSMUSG00000130109 ENSMUST00000298157.1 ENSMUSG00000130109 (from geneSymbol) uc334jdv.1 uc334jdv.1 
ENSMUST00000298158.1 ENSMUSG00000130110 ENSMUST00000298158.1 ENSMUSG00000130110 (from geneSymbol) uc334jdw.1 uc334jdw.1 
ENSMUST00000298159.1 ENSMUSG00000130111 ENSMUST00000298159.1 ENSMUSG00000130111 (from geneSymbol) uc334jdx.1 uc334jdx.1 
ENSMUST00000298169.1 ENSMUSG00000130113 ENSMUST00000298169.1 ENSMUSG00000130113 (from geneSymbol) uc334jef.1 uc334jef.1 
ENSMUST00000298173.1 ENSMUSG00000130114 ENSMUST00000298173.1 ENSMUSG00000130114 (from geneSymbol) LF196873 uc334jej.1 uc334jej.1 
ENSMUST00000298187.1 Gm28209 ENSMUST00000298187.1 Gm28209 (from geneSymbol) uc334jex.1 uc334jex.1 
ENSMUST00000298193.1 ENSMUSG00000130115 ENSMUST00000298193.1 ENSMUSG00000130115 (from geneSymbol) uc334jfd.1 uc334jfd.1 
ENSMUST00000298194.1 ENSMUSG00000130116 ENSMUST00000298194.1 ENSMUSG00000130116 (from geneSymbol) uc334jfe.1 uc334jfe.1 
ENSMUST00000298196.1 Gm21221 ENSMUST00000298196.1 Gm21221 (from geneSymbol) AK076945 uc334jfg.1 uc334jfg.1 
ENSMUST00000298201.1 ENSMUSG00000130117 ENSMUST00000298201.1 ENSMUSG00000130117 (from geneSymbol) uc334jfl.1 uc334jfl.1 
ENSMUST00000298202.1 ENSMUSG00000130118 ENSMUST00000298202.1 ENSMUSG00000130118 (from geneSymbol) uc334jfm.1 uc334jfm.1 
ENSMUST00000298203.1 ENSMUSG00000130119 ENSMUST00000298203.1 ENSMUSG00000130119 (from geneSymbol) uc334jfn.1 uc334jfn.1 
ENSMUST00000298205.1 ENSMUSG00000130120 ENSMUST00000298205.1 ENSMUSG00000130120 (from geneSymbol) uc334jfp.1 uc334jfp.1 
ENSMUST00000298206.1 ENSMUSG00000130121 ENSMUST00000298206.1 ENSMUSG00000130121 (from geneSymbol) uc334jfq.1 uc334jfq.1 
ENSMUST00000298209.1 ENSMUSG00000130122 ENSMUST00000298209.1 ENSMUSG00000130122 (from geneSymbol) uc334jft.1 uc334jft.1 
ENSMUST00000298210.1 ENSMUSG00000130123 ENSMUST00000298210.1 ENSMUSG00000130123 (from geneSymbol) uc334jfu.1 uc334jfu.1 
ENSMUST00000298211.1 ENSMUSG00000130124 ENSMUST00000298211.1 ENSMUSG00000130124 (from geneSymbol) uc334jfv.1 uc334jfv.1 
ENSMUST00000298212.1 ENSMUSG00000130125 ENSMUST00000298212.1 ENSMUSG00000130125 (from geneSymbol) uc334jfw.1 uc334jfw.1 
ENSMUST00000298213.1 ENSMUSG00000130126 ENSMUST00000298213.1 ENSMUSG00000130126 (from geneSymbol) uc334jfx.1 uc334jfx.1 
ENSMUST00000298214.1 Gm37406 ENSMUST00000298214.1 Gm37406 (from geneSymbol) uc334jfy.1 uc334jfy.1 
ENSMUST00000298218.1 ENSMUSG00000130127 ENSMUST00000298218.1 ENSMUSG00000130127 (from geneSymbol) uc334jgc.1 uc334jgc.1 
ENSMUST00000298220.1 ENSMUSG00000130128 ENSMUST00000298220.1 ENSMUSG00000130128 (from geneSymbol) uc334jge.1 uc334jge.1 
ENSMUST00000298222.1 ENSMUSG00000130130 ENSMUST00000298222.1 ENSMUSG00000130130 (from geneSymbol) uc334jgf.1 uc334jgf.1 
ENSMUST00000298223.1 ENSMUSG00000130131 ENSMUST00000298223.1 ENSMUSG00000130131 (from geneSymbol) uc334jgg.1 uc334jgg.1 
ENSMUST00000298224.1 ENSMUSG00000130132 ENSMUST00000298224.1 ENSMUSG00000130132 (from geneSymbol) uc334jgh.1 uc334jgh.1 
ENSMUST00000298225.1 ENSMUSG00000130133 ENSMUST00000298225.1 ENSMUSG00000130133 (from geneSymbol) uc334jgi.1 uc334jgi.1 
ENSMUST00000298230.1 ENSMUSG00000130134 ENSMUST00000298230.1 ENSMUSG00000130134 (from geneSymbol) AK138443 uc334jgl.1 uc334jgl.1 
ENSMUST00000298238.1 ENSMUSG00000130135 ENSMUST00000298238.1 ENSMUSG00000130135 (from geneSymbol) uc334jgt.1 uc334jgt.1 
ENSMUST00000298239.1 ENSMUSG00000130136 ENSMUST00000298239.1 ENSMUSG00000130136 (from geneSymbol) uc334jgu.1 uc334jgu.1 
ENSMUST00000298241.1 ENSMUSG00000130137 ENSMUST00000298241.1 ENSMUSG00000130137 (from geneSymbol) uc334jgw.1 uc334jgw.1 
ENSMUST00000298246.1 ENSMUSG00000130138 ENSMUST00000298246.1 ENSMUSG00000130138 (from geneSymbol) uc334jhb.1 uc334jhb.1 
ENSMUST00000298249.1 Gm31831 ENSMUST00000298249.1 Gm31831 (from geneSymbol) uc334jhe.1 uc334jhe.1 
ENSMUST00000298254.1 Gm36732 ENSMUST00000298254.1 Gm36732 (from geneSymbol) uc334jhj.1 uc334jhj.1 
ENSMUST00000298258.1 ENSMUSG00000130140 ENSMUST00000298258.1 ENSMUSG00000130140 (from geneSymbol) uc334jhm.1 uc334jhm.1 
ENSMUST00000298260.1 ENSMUSG00000130141 ENSMUST00000298260.1 ENSMUSG00000130141 (from geneSymbol) uc334jho.1 uc334jho.1 
ENSMUST00000298264.1 ENSMUSG00000130142 ENSMUST00000298264.1 ENSMUSG00000130142 (from geneSymbol) uc334jhs.1 uc334jhs.1 
ENSMUST00000298266.1 ENSMUSG00000130143 ENSMUST00000298266.1 ENSMUSG00000130143 (from geneSymbol) uc334jhu.1 uc334jhu.1 
ENSMUST00000298270.1 ENSMUSG00000130144 ENSMUST00000298270.1 ENSMUSG00000130144 (from geneSymbol) uc334jhy.1 uc334jhy.1 
ENSMUST00000298272.1 ENSMUSG00000130145 ENSMUST00000298272.1 ENSMUSG00000130145 (from geneSymbol) uc334jia.1 uc334jia.1 
ENSMUST00000298277.1 ENSMUSG00000130146 ENSMUST00000298277.1 ENSMUSG00000130146 (from geneSymbol) uc334jif.1 uc334jif.1 
ENSMUST00000298280.1 ENSMUSG00000130148 ENSMUST00000298280.1 ENSMUSG00000130148 (from geneSymbol) uc334jih.1 uc334jih.1 
ENSMUST00000298282.1 ENSMUSG00000130149 ENSMUST00000298282.1 ENSMUSG00000130149 (from geneSymbol) uc334jij.1 uc334jij.1 
ENSMUST00000298284.1 ENSMUSG00000130150 ENSMUST00000298284.1 ENSMUSG00000130150 (from geneSymbol) uc334jil.1 uc334jil.1 
ENSMUST00000298286.1 ENSMUSG00000130151 ENSMUST00000298286.1 ENSMUSG00000130151 (from geneSymbol) uc334jin.1 uc334jin.1 
ENSMUST00000298292.1 ENSMUSG00000130152 ENSMUST00000298292.1 ENSMUSG00000130152 (from geneSymbol) uc334jit.1 uc334jit.1 
ENSMUST00000298299.1 ENSMUSG00000130153 ENSMUST00000298299.1 ENSMUSG00000130153 (from geneSymbol) uc334jja.1 uc334jja.1 
ENSMUST00000298300.1 ENSMUSG00000130154 ENSMUST00000298300.1 ENSMUSG00000130154 (from geneSymbol) uc334jjb.1 uc334jjb.1 
ENSMUST00000298302.1 ENSMUSG00000130155 ENSMUST00000298302.1 ENSMUSG00000130155 (from geneSymbol) uc334jjd.1 uc334jjd.1 
ENSMUST00000298311.1 Gm57349 ENSMUST00000298311.1 Gm57349 (from geneSymbol) KY467563 uc334jjm.1 uc334jjm.1 
ENSMUST00000298326.1 ENSMUSG00000130156 ENSMUST00000298326.1 ENSMUSG00000130156 (from geneSymbol) uc334jkb.1 uc334jkb.1 
ENSMUST00000298327.1 Gm12212 ENSMUST00000298327.1 Gm12212 (from geneSymbol) uc334jkc.1 uc334jkc.1 
ENSMUST00000298330.1 ENSMUSG00000130157 ENSMUST00000298330.1 ENSMUSG00000130157 (from geneSymbol) uc334jkf.1 uc334jkf.1 
ENSMUST00000298332.1 ENSMUSG00000130158 ENSMUST00000298332.1 ENSMUSG00000130158 (from geneSymbol) uc334jkh.1 uc334jkh.1 
ENSMUST00000298335.1 ENSMUSG00000130159 ENSMUST00000298335.1 ENSMUSG00000130159 (from geneSymbol) uc334jkk.1 uc334jkk.1 
ENSMUST00000298339.1 ENSMUSG00000130160 ENSMUST00000298339.1 ENSMUSG00000130160 (from geneSymbol) uc334jko.1 uc334jko.1 
ENSMUST00000298341.1 ENSMUSG00000130161 ENSMUST00000298341.1 ENSMUSG00000130161 (from geneSymbol) uc334jkq.1 uc334jkq.1 
ENSMUST00000298342.1 ENSMUSG00000130162 ENSMUST00000298342.1 ENSMUSG00000130162 (from geneSymbol) uc334jkr.1 uc334jkr.1 
ENSMUST00000298344.1 ENSMUSG00000130163 ENSMUST00000298344.1 ENSMUSG00000130163 (from geneSymbol) uc334jkt.1 uc334jkt.1 
ENSMUST00000298353.1 ENSMUSG00000130164 ENSMUST00000298353.1 ENSMUSG00000130164 (from geneSymbol) uc334jlc.1 uc334jlc.1 
ENSMUST00000298354.1 ENSMUSG00000130165 ENSMUST00000298354.1 ENSMUSG00000130165 (from geneSymbol) uc334jld.1 uc334jld.1 
ENSMUST00000298357.1 Gm43646 ENSMUST00000298357.1 Gm43646 (from geneSymbol) AK085299 uc334jlg.1 uc334jlg.1 
ENSMUST00000298363.1 ENSMUSG00000130166 ENSMUST00000298363.1 ENSMUSG00000130166 (from geneSymbol) uc334jlm.1 uc334jlm.1 
ENSMUST00000298364.1 ENSMUSG00000130167 ENSMUST00000298364.1 ENSMUSG00000130167 (from geneSymbol) uc334jln.1 uc334jln.1 
ENSMUST00000298368.1 ENSMUSG00000130168 ENSMUST00000298368.1 ENSMUSG00000130168 (from geneSymbol) uc334jlr.1 uc334jlr.1 
ENSMUST00000298369.1 ENSMUSG00000130169 ENSMUST00000298369.1 ENSMUSG00000130169 (from geneSymbol) uc334jls.1 uc334jls.1 
ENSMUST00000298370.1 ENSMUSG00000130170 ENSMUST00000298370.1 ENSMUSG00000130170 (from geneSymbol) uc334jlt.1 uc334jlt.1 
ENSMUST00000298371.1 ENSMUSG00000130171 ENSMUST00000298371.1 ENSMUSG00000130171 (from geneSymbol) uc334jlu.1 uc334jlu.1 
ENSMUST00000298372.1 ENSMUSG00000130172 ENSMUST00000298372.1 ENSMUSG00000130172 (from geneSymbol) uc334jlv.1 uc334jlv.1 
ENSMUST00000298374.1 ENSMUSG00000130173 ENSMUST00000298374.1 ENSMUSG00000130173 (from geneSymbol) uc334jlx.1 uc334jlx.1 
ENSMUST00000298377.1 ENSMUSG00000130174 ENSMUST00000298377.1 ENSMUSG00000130174 (from geneSymbol) uc334jma.1 uc334jma.1 
ENSMUST00000298382.1 Gm57174 ENSMUST00000298382.1 Gm57174 (from geneSymbol) uc334jmf.1 uc334jmf.1 
ENSMUST00000298389.1 ENSMUSG00000130175 ENSMUST00000298389.1 ENSMUSG00000130175 (from geneSymbol) uc334jmm.1 uc334jmm.1 
ENSMUST00000298390.1 ENSMUSG00000130176 ENSMUST00000298390.1 ENSMUSG00000130176 (from geneSymbol) uc334jmn.1 uc334jmn.1 
ENSMUST00000298394.1 Gm32341 ENSMUST00000298394.1 Gm32341 (from geneSymbol) uc334jmr.1 uc334jmr.1 
ENSMUST00000298398.1 ENSMUSG00000130177 ENSMUST00000298398.1 ENSMUSG00000130177 (from geneSymbol) uc334jmv.1 uc334jmv.1 
ENSMUST00000298399.1 Gm12496 ENSMUST00000298399.1 Gm12496 (from geneSymbol) uc334jmw.1 uc334jmw.1 
ENSMUST00000298401.1 ENSMUSG00000130178 ENSMUST00000298401.1 ENSMUSG00000130178 (from geneSymbol) uc334jmy.1 uc334jmy.1 
ENSMUST00000298403.1 ENSMUSG00000130179 ENSMUST00000298403.1 ENSMUSG00000130179 (from geneSymbol) uc334jna.1 uc334jna.1 
ENSMUST00000298407.1 ENSMUSG00000130180 ENSMUST00000298407.1 ENSMUSG00000130180 (from geneSymbol) uc334jne.1 uc334jne.1 
ENSMUST00000298410.1 ENSMUSG00000130181 ENSMUST00000298410.1 ENSMUSG00000130181 (from geneSymbol) uc334jnh.1 uc334jnh.1 
ENSMUST00000298411.1 ENSMUSG00000130182 ENSMUST00000298411.1 ENSMUSG00000130182 (from geneSymbol) uc334jni.1 uc334jni.1 
ENSMUST00000298413.1 ENSMUSG00000130183 ENSMUST00000298413.1 ENSMUSG00000130183 (from geneSymbol) uc334jnk.1 uc334jnk.1 
ENSMUST00000298414.1 ENSMUSG00000130184 ENSMUST00000298414.1 ENSMUSG00000130184 (from geneSymbol) uc334jnl.1 uc334jnl.1 
ENSMUST00000298417.1 ENSMUSG00000130185 ENSMUST00000298417.1 ENSMUSG00000130185 (from geneSymbol) uc334jno.1 uc334jno.1 
ENSMUST00000298419.1 ENSMUSG00000130186 ENSMUST00000298419.1 ENSMUSG00000130186 (from geneSymbol) uc334jnq.1 uc334jnq.1 
ENSMUST00000298423.1 ENSMUSG00000130187 ENSMUST00000298423.1 ENSMUSG00000130187 (from geneSymbol) uc334jnu.1 uc334jnu.1 
ENSMUST00000298425.1 ENSMUSG00000130188 ENSMUST00000298425.1 ENSMUSG00000130188 (from geneSymbol) uc334jnw.1 uc334jnw.1 
ENSMUST00000298429.1 ENSMUSG00000130189 ENSMUST00000298429.1 ENSMUSG00000130189 (from geneSymbol) uc334joa.1 uc334joa.1 
ENSMUST00000298430.1 ENSMUSG00000130190 ENSMUST00000298430.1 ENSMUSG00000130190 (from geneSymbol) uc334job.1 uc334job.1 
ENSMUST00000298432.1 ENSMUSG00000130191 ENSMUST00000298432.1 ENSMUSG00000130191 (from geneSymbol) uc334jod.1 uc334jod.1 
ENSMUST00000298433.1 Gm14104 ENSMUST00000298433.1 Gm14104 (from geneSymbol) uc334joe.1 uc334joe.1 
ENSMUST00000298441.1 ENSMUSG00000130192 ENSMUST00000298441.1 ENSMUSG00000130192 (from geneSymbol) uc334jom.1 uc334jom.1 
ENSMUST00000298450.1 ENSMUSG00000130193 ENSMUST00000298450.1 ENSMUSG00000130193 (from geneSymbol) uc334jov.1 uc334jov.1 
ENSMUST00000298451.1 ENSMUSG00000130194 ENSMUST00000298451.1 ENSMUSG00000130194 (from geneSymbol) uc334jow.1 uc334jow.1 
ENSMUST00000298452.1 ENSMUSG00000130195 ENSMUST00000298452.1 ENSMUSG00000130195 (from geneSymbol) uc334jox.1 uc334jox.1 
ENSMUST00000298454.1 ENSMUSG00000130196 ENSMUST00000298454.1 ENSMUSG00000130196 (from geneSymbol) uc334joz.1 uc334joz.1 
ENSMUST00000298460.1 ENSMUSG00000130197 ENSMUST00000298460.1 ENSMUSG00000130197 (from geneSymbol) uc334jpf.1 uc334jpf.1 
ENSMUST00000298462.1 ENSMUSG00000130198 ENSMUST00000298462.1 ENSMUSG00000130198 (from geneSymbol) uc334jph.1 uc334jph.1 
ENSMUST00000298464.1 ENSMUSG00000130199 ENSMUST00000298464.1 ENSMUSG00000130199 (from geneSymbol) uc334jpj.1 uc334jpj.1 
ENSMUST00000298470.1 ENSMUSG00000130200 ENSMUST00000298470.1 ENSMUSG00000130200 (from geneSymbol) uc334jpp.1 uc334jpp.1 
ENSMUST00000298471.1 ENSMUSG00000130201 ENSMUST00000298471.1 ENSMUSG00000130201 (from geneSymbol) uc334jpq.1 uc334jpq.1 
ENSMUST00000298473.1 ENSMUSG00000130202 ENSMUST00000298473.1 ENSMUSG00000130202 (from geneSymbol) uc334jps.1 uc334jps.1 
ENSMUST00000298474.1 ENSMUSG00000130203 ENSMUST00000298474.1 ENSMUSG00000130203 (from geneSymbol) uc334jpt.1 uc334jpt.1 
ENSMUST00000298490.1 ENSMUSG00000130204 ENSMUST00000298490.1 ENSMUSG00000130204 (from geneSymbol) uc334jqj.1 uc334jqj.1 
ENSMUST00000298502.1 ENSMUSG00000130205 ENSMUST00000298502.1 ENSMUSG00000130205 (from geneSymbol) uc334jqv.1 uc334jqv.1 
ENSMUST00000298507.1 ENSMUSG00000130206 ENSMUST00000298507.1 ENSMUSG00000130206 (from geneSymbol) uc334jra.1 uc334jra.1 
ENSMUST00000298508.1 ENSMUSG00000130207 ENSMUST00000298508.1 ENSMUSG00000130207 (from geneSymbol) uc334jrb.1 uc334jrb.1 
ENSMUST00000298509.1 ENSMUSG00000130208 ENSMUST00000298509.1 ENSMUSG00000130208 (from geneSymbol) uc334jrc.1 uc334jrc.1 
ENSMUST00000298510.1 ENSMUSG00000130209 ENSMUST00000298510.1 ENSMUSG00000130209 (from geneSymbol) uc334jrd.1 uc334jrd.1 
ENSMUST00000298512.1 ENSMUSG00000130210 ENSMUST00000298512.1 ENSMUSG00000130210 (from geneSymbol) uc334jrf.1 uc334jrf.1 
ENSMUST00000298518.1 ENSMUSG00000130211 ENSMUST00000298518.1 RIKEN cDNA 4930487H11 gene (from RefSeq NR_040601.1) NR_040601 uc334jrl.1 uc334jrl.1 
ENSMUST00000298521.1 ENSMUSG00000130212 ENSMUST00000298521.1 ENSMUSG00000130212 (from geneSymbol) uc334jro.1 uc334jro.1 
ENSMUST00000298544.1 ENSMUSG00000130213 ENSMUST00000298544.1 ENSMUSG00000130213 (from geneSymbol) uc334jsl.1 uc334jsl.1 
ENSMUST00000298545.1 ENSMUSG00000130214 ENSMUST00000298545.1 ENSMUSG00000130214 (from geneSymbol) uc334jsm.1 uc334jsm.1 
ENSMUST00000298549.1 Lexis1 ENSMUST00000298549.1 Lexis1 (from geneSymbol) AK015122 uc334jsq.1 uc334jsq.1 
ENSMUST00000298555.1 ENSMUSG00000130215 ENSMUST00000298555.1 ENSMUSG00000130215 (from geneSymbol) uc334jsw.1 uc334jsw.1 
ENSMUST00000298562.1 C130026L21Rik ENSMUST00000298562.1 C130026L21Rik (from geneSymbol) AK160721 uc334jtd.1 uc334jtd.1 
ENSMUST00000298622.1 Gm13003 ENSMUST00000298622.1 Gm13003 (from geneSymbol) AK132559 uc334jvl.1 uc334jvl.1 
ENSMUST00000298635.1 ENSMUSG00000130216 ENSMUST00000298635.1 ENSMUSG00000130216 (from geneSymbol) uc334jvy.1 uc334jvy.1 
ENSMUST00000298636.1 ENSMUSG00000130217 ENSMUST00000298636.1 ENSMUSG00000130217 (from geneSymbol) uc334jvz.1 uc334jvz.1 
ENSMUST00000298638.1 4930553E22Rik ENSMUST00000298638.1 4930553E22Rik (from geneSymbol) AK016102 uc334jwb.1 uc334jwb.1 
ENSMUST00000298647.1 ENSMUSG00000130218 ENSMUST00000298647.1 ENSMUSG00000130218 (from geneSymbol) uc334jwk.1 uc334jwk.1 
ENSMUST00000298648.1 ENSMUSG00000130219 ENSMUST00000298648.1 ENSMUSG00000130219 (from geneSymbol) uc334jwl.1 uc334jwl.1 
ENSMUST00000298649.1 ENSMUSG00000130220 ENSMUST00000298649.1 ENSMUSG00000130220 (from geneSymbol) uc334jwm.1 uc334jwm.1 
ENSMUST00000298650.1 Gm57155 ENSMUST00000298650.1 Gm57155 (from geneSymbol) uc334jwn.1 uc334jwn.1 
ENSMUST00000298651.1 ENSMUSG00000130221 ENSMUST00000298651.1 ENSMUSG00000130221 (from geneSymbol) uc334jwo.1 uc334jwo.1 
ENSMUST00000298652.1 ENSMUSG00000130222 ENSMUST00000298652.1 ENSMUSG00000130222 (from geneSymbol) uc334jwp.1 uc334jwp.1 
ENSMUST00000298653.1 ENSMUSG00000130223 ENSMUST00000298653.1 ENSMUSG00000130223 (from geneSymbol) uc334jwq.1 uc334jwq.1 
ENSMUST00000298657.1 ENSMUSG00000130224 ENSMUST00000298657.1 ENSMUSG00000130224 (from geneSymbol) uc334jwu.1 uc334jwu.1 
ENSMUST00000298658.1 ENSMUSG00000130225 ENSMUST00000298658.1 ENSMUSG00000130225 (from geneSymbol) uc334jwv.1 uc334jwv.1 
ENSMUST00000298664.1 ENSMUSG00000130226 ENSMUST00000298664.1 ENSMUSG00000130226 (from geneSymbol) uc334jxb.1 uc334jxb.1 
ENSMUST00000298665.1 ENSMUSG00000130227 ENSMUST00000298665.1 ENSMUSG00000130227 (from geneSymbol) uc334jxc.1 uc334jxc.1 
ENSMUST00000298667.1 ENSMUSG00000130228 ENSMUST00000298667.1 ENSMUSG00000130228 (from geneSymbol) uc334jxe.1 uc334jxe.1 
ENSMUST00000298672.1 ENSMUSG00000130229 ENSMUST00000298672.1 ENSMUSG00000130229 (from geneSymbol) uc334jxj.1 uc334jxj.1 
ENSMUST00000298673.1 ENSMUSG00000130230 ENSMUST00000298673.1 ENSMUSG00000130230 (from geneSymbol) uc334jxk.1 uc334jxk.1 
ENSMUST00000298675.1 ENSMUSG00000130231 ENSMUST00000298675.1 ENSMUSG00000130231 (from geneSymbol) uc334jxm.1 uc334jxm.1 
ENSMUST00000298676.1 ENSMUSG00000130232 ENSMUST00000298676.1 ENSMUSG00000130232 (from geneSymbol) uc334jxn.1 uc334jxn.1 
ENSMUST00000298677.1 ENSMUSG00000130233 ENSMUST00000298677.1 ENSMUSG00000130233 (from geneSymbol) uc334jxo.1 uc334jxo.1 
ENSMUST00000298678.1 ENSMUSG00000130234 ENSMUST00000298678.1 ENSMUSG00000130234 (from geneSymbol) uc334jxp.1 uc334jxp.1 
ENSMUST00000298679.1 ENSMUSG00000130235 ENSMUST00000298679.1 ENSMUSG00000130235 (from geneSymbol) uc334jxq.1 uc334jxq.1 
ENSMUST00000298682.1 ENSMUSG00000130236 ENSMUST00000298682.1 ENSMUSG00000130236 (from geneSymbol) uc334jxt.1 uc334jxt.1 
ENSMUST00000298684.1 ENSMUSG00000130237 ENSMUST00000298684.1 ENSMUSG00000130237 (from geneSymbol) uc334jxv.1 uc334jxv.1 
ENSMUST00000298685.1 ENSMUSG00000130238 ENSMUST00000298685.1 ENSMUSG00000130238 (from geneSymbol) uc334jxw.1 uc334jxw.1 
ENSMUST00000298686.1 ENSMUSG00000130239 ENSMUST00000298686.1 ENSMUSG00000130239 (from geneSymbol) uc334jxx.1 uc334jxx.1 
ENSMUST00000298687.1 ENSMUSG00000130240 ENSMUST00000298687.1 ENSMUSG00000130240 (from geneSymbol) uc334jxy.1 uc334jxy.1 
ENSMUST00000298692.1 ENSMUSG00000130241 ENSMUST00000298692.1 ENSMUSG00000130241 (from geneSymbol) uc334jyd.1 uc334jyd.1 
ENSMUST00000298693.1 ENSMUSG00000130242 ENSMUST00000298693.1 ENSMUSG00000130242 (from geneSymbol) uc334jye.1 uc334jye.1 
ENSMUST00000298696.1 ENSMUSG00000130243 ENSMUST00000298696.1 ENSMUSG00000130243 (from geneSymbol) uc334jyg.1 uc334jyg.1 
ENSMUST00000298709.1 ENSMUSG00000130245 ENSMUST00000298709.1 ENSMUSG00000130245 (from geneSymbol) uc334jyn.1 uc334jyn.1 
ENSMUST00000298712.1 ENSMUSG00000130246 ENSMUST00000298712.1 ENSMUSG00000130246 (from geneSymbol) uc334jyq.1 uc334jyq.1 
ENSMUST00000298717.1 ENSMUSG00000130247 ENSMUST00000298717.1 ENSMUSG00000130247 (from geneSymbol) uc334jyv.1 uc334jyv.1 
ENSMUST00000298724.1 ENSMUSG00000130248 ENSMUST00000298724.1 ENSMUSG00000130248 (from geneSymbol) AK132462 uc334jzc.1 uc334jzc.1 
ENSMUST00000298726.1 ENSMUSG00000130249 ENSMUST00000298726.1 ENSMUSG00000130249 (from geneSymbol) uc334jze.1 uc334jze.1 
ENSMUST00000298730.1 ENSMUSG00000130250 ENSMUST00000298730.1 ENSMUSG00000130250 (from geneSymbol) uc334jzi.1 uc334jzi.1 
ENSMUST00000298731.1 ENSMUSG00000130251 ENSMUST00000298731.1 ENSMUSG00000130251 (from geneSymbol) uc334jzj.1 uc334jzj.1 
ENSMUST00000298732.1 ENSMUSG00000130252 ENSMUST00000298732.1 ENSMUSG00000130252 (from geneSymbol) uc334jzk.1 uc334jzk.1 
ENSMUST00000298733.1 ENSMUSG00000130253 ENSMUST00000298733.1 ENSMUSG00000130253 (from geneSymbol) uc334jzl.1 uc334jzl.1 
ENSMUST00000298736.1 ENSMUSG00000130254 ENSMUST00000298736.1 ENSMUSG00000130254 (from geneSymbol) uc334jzo.1 uc334jzo.1 
ENSMUST00000298749.1 ENSMUSG00000130255 ENSMUST00000298749.1 ENSMUSG00000130255 (from geneSymbol) uc334jzz.1 uc334jzz.1 
ENSMUST00000298750.1 ENSMUSG00000130256 ENSMUST00000298750.1 ENSMUSG00000130256 (from geneSymbol) uc334kaa.1 uc334kaa.1 
ENSMUST00000298751.1 ENSMUSG00000130257 ENSMUST00000298751.1 ENSMUSG00000130257 (from geneSymbol) uc334kab.1 uc334kab.1 
ENSMUST00000298753.1 ENSMUSG00000130258 ENSMUST00000298753.1 ENSMUSG00000130258 (from geneSymbol) uc334kad.1 uc334kad.1 
ENSMUST00000298754.1 ENSMUSG00000130259 ENSMUST00000298754.1 ENSMUSG00000130259 (from geneSymbol) uc334kae.1 uc334kae.1 
ENSMUST00000298758.1 ENSMUSG00000130260 ENSMUST00000298758.1 ENSMUSG00000130260 (from geneSymbol) uc334kai.1 uc334kai.1 
ENSMUST00000298774.1 Gm9908 ENSMUST00000298774.1 Gm9908 (from geneSymbol) uc334kay.1 uc334kay.1 
ENSMUST00000298776.1 ENSMUSG00000130261 ENSMUST00000298776.1 ENSMUSG00000130261 (from geneSymbol) uc334kba.1 uc334kba.1 
ENSMUST00000298781.1 ENSMUSG00000130262 ENSMUST00000298781.1 ENSMUSG00000130262 (from geneSymbol) uc334kbf.1 uc334kbf.1 
ENSMUST00000298782.1 ENSMUSG00000130263 ENSMUST00000298782.1 ENSMUSG00000130263 (from geneSymbol) uc334kbg.1 uc334kbg.1 
ENSMUST00000298784.1 ENSMUSG00000130265 ENSMUST00000298784.1 ENSMUSG00000130265 (from geneSymbol) uc334kbh.1 uc334kbh.1 
ENSMUST00000298786.1 ENSMUSG00000130266 ENSMUST00000298786.1 ENSMUSG00000130266 (from geneSymbol) uc334kbj.1 uc334kbj.1 
ENSMUST00000298789.1 ENSMUSG00000130267 ENSMUST00000298789.1 ENSMUSG00000130267 (from geneSymbol) uc334kbm.1 uc334kbm.1 
ENSMUST00000298791.1 ENSMUSG00000130268 ENSMUST00000298791.1 ENSMUSG00000130268 (from geneSymbol) uc334kbo.1 uc334kbo.1 
ENSMUST00000298792.1 ENSMUSG00000130269 ENSMUST00000298792.1 ENSMUSG00000130269 (from geneSymbol) uc334kbp.1 uc334kbp.1 
ENSMUST00000298793.1 ENSMUSG00000130270 ENSMUST00000298793.1 ENSMUSG00000130270 (from geneSymbol) uc334kbq.1 uc334kbq.1 
ENSMUST00000298803.1 ENSMUSG00000130271 ENSMUST00000298803.1 ENSMUSG00000130271 (from geneSymbol) uc334kca.1 uc334kca.1 
ENSMUST00000298805.1 ENSMUSG00000130272 ENSMUST00000298805.1 ENSMUSG00000130272 (from geneSymbol) uc334kcc.1 uc334kcc.1 
ENSMUST00000298807.1 ENSMUSG00000130273 ENSMUST00000298807.1 ENSMUSG00000130273 (from geneSymbol) uc334kce.1 uc334kce.1 
ENSMUST00000298808.1 ENSMUSG00000130274 ENSMUST00000298808.1 ENSMUSG00000130274 (from geneSymbol) uc334kcf.1 uc334kcf.1 
ENSMUST00000298810.1 ENSMUSG00000130275 ENSMUST00000298810.1 ENSMUSG00000130275 (from geneSymbol) uc334kch.1 uc334kch.1 
ENSMUST00000298811.1 C530025M09Rik ENSMUST00000298811.1 C530025M09Rik (from geneSymbol) uc334kci.1 uc334kci.1 
ENSMUST00000298812.1 ENSMUSG00000130276 ENSMUST00000298812.1 ENSMUSG00000130276 (from geneSymbol) uc334kcj.1 uc334kcj.1 
ENSMUST00000298814.1 ENSMUSG00000130277 ENSMUST00000298814.1 ENSMUSG00000130277 (from geneSymbol) uc334kcl.1 uc334kcl.1 
ENSMUST00000298815.1 ENSMUSG00000130278 ENSMUST00000298815.1 ENSMUSG00000130278 (from geneSymbol) uc334kcm.1 uc334kcm.1 
ENSMUST00000298824.1 ENSMUSG00000130279 ENSMUST00000298824.1 ENSMUSG00000130279 (from geneSymbol) uc334kcv.1 uc334kcv.1 
ENSMUST00000298826.1 ENSMUSG00000130280 ENSMUST00000298826.1 ENSMUSG00000130280 (from geneSymbol) uc334kcx.1 uc334kcx.1 
ENSMUST00000298827.1 Gm29860 ENSMUST00000298827.1 Gm29860 (from geneSymbol) uc334kcy.1 uc334kcy.1 
ENSMUST00000298865.1 ENSMUSG00000130281 ENSMUST00000298865.1 ENSMUSG00000130281 (from geneSymbol) uc334kek.1 uc334kek.1 
ENSMUST00000298866.1 ENSMUSG00000130282 ENSMUST00000298866.1 ENSMUSG00000130282 (from geneSymbol) uc334kel.1 uc334kel.1 
ENSMUST00000298867.1 ENSMUSG00000130283 ENSMUST00000298867.1 ENSMUSG00000130283 (from geneSymbol) uc334kem.1 uc334kem.1 
ENSMUST00000298868.1 ENSMUSG00000130284 ENSMUST00000298868.1 ENSMUSG00000130284 (from geneSymbol) uc334ken.1 uc334ken.1 
ENSMUST00000298871.1 ENSMUSG00000130285 ENSMUST00000298871.1 ENSMUSG00000130285 (from geneSymbol) uc334keq.1 uc334keq.1 
ENSMUST00000298887.1 Gm33148 ENSMUST00000298887.1 Gm33148 (from geneSymbol) KY468170 uc334kfg.1 uc334kfg.1 
ENSMUST00000298921.1 ENSMUSG00000121508 ENSMUST00000298921.1 ENSMUSG00000121508 (from geneSymbol) uc334kgo.1 uc334kgo.1 
ENSMUST00000298927.1 ENSMUSG00000130286 ENSMUST00000298927.1 ENSMUSG00000130286 (from geneSymbol) uc334kgu.1 uc334kgu.1 
ENSMUST00000298943.1 ENSMUSG00000130287 ENSMUST00000298943.1 ENSMUSG00000130287 (from geneSymbol) uc334khk.1 uc334khk.1 
ENSMUST00000298945.1 ENSMUSG00000130288 ENSMUST00000298945.1 ENSMUSG00000130288 (from geneSymbol) uc334khm.1 uc334khm.1 
ENSMUST00000298947.1 ENSMUSG00000130289 ENSMUST00000298947.1 ENSMUSG00000130289 (from geneSymbol) uc334kho.1 uc334kho.1 
ENSMUST00000298949.1 ENSMUSG00000130290 ENSMUST00000298949.1 ENSMUSG00000130290 (from geneSymbol) uc334khq.1 uc334khq.1 
ENSMUST00000298952.1 ENSMUSG00000130291 ENSMUST00000298952.1 ENSMUSG00000130291 (from geneSymbol) uc334kht.1 uc334kht.1 
ENSMUST00000298956.1 ENSMUSG00000130292 ENSMUST00000298956.1 ENSMUSG00000130292 (from geneSymbol) uc334khx.1 uc334khx.1 
ENSMUST00000298958.1 ENSMUSG00000130293 ENSMUST00000298958.1 ENSMUSG00000130293 (from geneSymbol) uc334khz.1 uc334khz.1 
ENSMUST00000298960.1 ENSMUSG00000130294 ENSMUST00000298960.1 ENSMUSG00000130294 (from geneSymbol) uc334kib.1 uc334kib.1 
ENSMUST00000298961.1 ENSMUSG00000130295 ENSMUST00000298961.1 ENSMUSG00000130295 (from geneSymbol) uc334kic.1 uc334kic.1 
ENSMUST00000298963.1 ENSMUSG00000130296 ENSMUST00000298963.1 ENSMUSG00000130296 (from geneSymbol) uc334kie.1 uc334kie.1 
ENSMUST00000298964.1 Gm41998 ENSMUST00000298964.1 Gm41998 (from geneSymbol) uc334kif.1 uc334kif.1 
ENSMUST00000298971.1 ENSMUSG00000130298 ENSMUST00000298971.1 ENSMUSG00000130298 (from geneSymbol) uc334kim.1 uc334kim.1 
ENSMUST00000298977.1 ENSMUSG00000130299 ENSMUST00000298977.1 ENSMUSG00000130299 (from geneSymbol) uc334kis.1 uc334kis.1 
ENSMUST00000298978.1 ENSMUSG00000130300 ENSMUST00000298978.1 ENSMUSG00000130300 (from geneSymbol) uc334kit.1 uc334kit.1 
ENSMUST00000298980.1 ENSMUSG00000130301 ENSMUST00000298980.1 ENSMUSG00000130301 (from geneSymbol) AK033021 uc334kiv.1 uc334kiv.1 
ENSMUST00000298981.1 ENSMUSG00000130302 ENSMUST00000298981.1 ENSMUSG00000130302 (from geneSymbol) uc334kiw.1 uc334kiw.1 
ENSMUST00000298982.1 ENSMUSG00000130303 ENSMUST00000298982.1 ENSMUSG00000130303 (from geneSymbol) uc334kix.1 uc334kix.1 
ENSMUST00000298984.1 Gm35240 ENSMUST00000298984.1 Gm35240 (from geneSymbol) uc334kiz.1 uc334kiz.1 
ENSMUST00000298992.1 ENSMUSG00000130304 ENSMUST00000298992.1 ENSMUSG00000130304 (from geneSymbol) uc334kjh.1 uc334kjh.1 
ENSMUST00000298993.1 ENSMUSG00000130305 ENSMUST00000298993.1 ENSMUSG00000130305 (from geneSymbol) uc334kji.1 uc334kji.1 
ENSMUST00000298994.1 ENSMUSG00000130306 ENSMUST00000298994.1 ENSMUSG00000130306 (from geneSymbol) uc334kjj.1 uc334kjj.1 
ENSMUST00000298996.1 ENSMUSG00000130307 ENSMUST00000298996.1 ENSMUSG00000130307 (from geneSymbol) uc334kjl.1 uc334kjl.1 
ENSMUST00000298997.1 ENSMUSG00000130308 ENSMUST00000298997.1 ENSMUSG00000130308 (from geneSymbol) uc334kjm.1 uc334kjm.1 
ENSMUST00000298999.1 ENSMUSG00000130309 ENSMUST00000298999.1 ENSMUSG00000130309 (from geneSymbol) uc334kjo.1 uc334kjo.1 
ENSMUST00000299000.1 ENSMUSG00000130310 ENSMUST00000299000.1 ENSMUSG00000130310 (from geneSymbol) uc334kjp.1 uc334kjp.1 
ENSMUST00000299013.1 ENSMUSG00000130311 ENSMUST00000299013.1 ENSMUSG00000130311 (from geneSymbol) uc334kkc.1 uc334kkc.1 
ENSMUST00000299014.1 ENSMUSG00000130312 ENSMUST00000299014.1 ENSMUSG00000130312 (from geneSymbol) uc334kkd.1 uc334kkd.1 
ENSMUST00000299016.1 ENSMUSG00000130313 ENSMUST00000299016.1 ENSMUSG00000130313 (from geneSymbol) uc334kkf.1 uc334kkf.1 
ENSMUST00000299017.1 ENSMUSG00000130314 ENSMUST00000299017.1 ENSMUSG00000130314 (from geneSymbol) uc334kkg.1 uc334kkg.1 
ENSMUST00000299018.1 ENSMUSG00000130315 ENSMUST00000299018.1 ENSMUSG00000130315 (from geneSymbol) uc334kkh.1 uc334kkh.1 
ENSMUST00000299023.1 ENSMUSG00000130316 ENSMUST00000299023.1 ENSMUSG00000130316 (from geneSymbol) uc334kkm.1 uc334kkm.1 
ENSMUST00000299028.1 ENSMUSG00000130317 ENSMUST00000299028.1 ENSMUSG00000130317 (from geneSymbol) uc334kkr.1 uc334kkr.1 
ENSMUST00000299030.1 ENSMUSG00000130318 ENSMUST00000299030.1 ENSMUSG00000130318 (from geneSymbol) uc334kkt.1 uc334kkt.1 
ENSMUST00000299032.1 ENSMUSG00000130319 ENSMUST00000299032.1 ENSMUSG00000130319 (from geneSymbol) uc334kkv.1 uc334kkv.1 
ENSMUST00000299043.1 Gm35229 ENSMUST00000299043.1 Gm35229 (from geneSymbol) uc334klg.1 uc334klg.1 
ENSMUST00000299063.1 ENSMUSG00000130320 ENSMUST00000299063.1 ENSMUSG00000130320 (from geneSymbol) uc334kma.1 uc334kma.1 
ENSMUST00000299064.1 ENSMUSG00000130321 ENSMUST00000299064.1 ENSMUSG00000130321 (from geneSymbol) uc334kmb.1 uc334kmb.1 
ENSMUST00000299065.1 ENSMUSG00000130322 ENSMUST00000299065.1 ENSMUSG00000130322 (from geneSymbol) uc334kmc.1 uc334kmc.1 
ENSMUST00000299066.1 ENSMUSG00000130323 ENSMUST00000299066.1 ENSMUSG00000130323 (from geneSymbol) uc334kmd.1 uc334kmd.1 
ENSMUST00000299079.1 Gm26636 ENSMUST00000299079.1 Gm26636 (from geneSymbol) AK089147 uc334kmq.1 uc334kmq.1 
ENSMUST00000299084.1 ENSMUSG00000130324 ENSMUST00000299084.1 ENSMUSG00000130324 (from geneSymbol) uc334kmv.1 uc334kmv.1 
ENSMUST00000299087.1 Gm30042 ENSMUST00000299087.1 Gm30042 (from geneSymbol) uc334kmy.1 uc334kmy.1 
ENSMUST00000299119.1 ENSMUSG00000130325 ENSMUST00000299119.1 ENSMUSG00000130325 (from geneSymbol) uc334koe.1 uc334koe.1 
ENSMUST00000299120.1 ENSMUSG00000130326 ENSMUST00000299120.1 ENSMUSG00000130326 (from geneSymbol) uc334kof.1 uc334kof.1 
ENSMUST00000299121.1 ENSMUSG00000130327 ENSMUST00000299121.1 ENSMUSG00000130327 (from geneSymbol) uc334kog.1 uc334kog.1 
ENSMUST00000299124.1 ENSMUSG00000130328 ENSMUST00000299124.1 ENSMUSG00000130328 (from geneSymbol) uc334koj.1 uc334koj.1 
ENSMUST00000299125.1 ENSMUSG00000130329 ENSMUST00000299125.1 ENSMUSG00000130329 (from geneSymbol) uc334kok.1 uc334kok.1 
ENSMUST00000299127.1 Nctc1 ENSMUST00000299127.1 Nctc1 (from geneSymbol) AK035596 uc334kom.1 uc334kom.1 
ENSMUST00000299133.1 Gm35933 ENSMUST00000299133.1 Gm35933 (from geneSymbol) uc334kos.1 uc334kos.1 
ENSMUST00000299156.1 ENSMUSG00000130330 ENSMUST00000299156.1 ENSMUSG00000130330 (from geneSymbol) uc334kpp.1 uc334kpp.1 
ENSMUST00000299162.1 ENSMUSG00000130331 ENSMUST00000299162.1 ENSMUSG00000130331 (from geneSymbol) uc334kpv.1 uc334kpv.1 
ENSMUST00000299181.1 ENSMUSG00000130333 ENSMUST00000299181.1 ENSMUSG00000130333 (from geneSymbol) uc334kpx.1 uc334kpx.1 
ENSMUST00000299186.1 ENSMUSG00000130334 ENSMUST00000299186.1 ENSMUSG00000130334 (from geneSymbol) uc334kqc.1 uc334kqc.1 
ENSMUST00000299188.1 ENSMUSG00000130335 ENSMUST00000299188.1 ENSMUSG00000130335 (from geneSymbol) uc334kqe.1 uc334kqe.1 
ENSMUST00000299193.1 ENSMUSG00000130336 ENSMUST00000299193.1 ENSMUSG00000130336 (from geneSymbol) uc334kqj.1 uc334kqj.1 
ENSMUST00000299202.1 ENSMUSG00000130337 ENSMUST00000299202.1 ENSMUSG00000130337 (from geneSymbol) uc334kqs.1 uc334kqs.1 
ENSMUST00000299204.1 ENSMUSG00000130339 ENSMUST00000299204.1 ENSMUSG00000130339 (from geneSymbol) uc334kqt.1 uc334kqt.1 
ENSMUST00000299206.1 ENSMUSG00000130340 ENSMUST00000299206.1 ENSMUSG00000130340 (from geneSymbol) uc334kqv.1 uc334kqv.1 
ENSMUST00000299207.1 ENSMUSG00000130341 ENSMUST00000299207.1 ENSMUSG00000130341 (from geneSymbol) uc334kqw.1 uc334kqw.1 
ENSMUST00000299208.1 ENSMUSG00000130342 ENSMUST00000299208.1 ENSMUSG00000130342 (from geneSymbol) uc334kqx.1 uc334kqx.1 
ENSMUST00000299210.1 ENSMUSG00000130343 ENSMUST00000299210.1 ENSMUSG00000130343 (from geneSymbol) uc334kqz.1 uc334kqz.1 
ENSMUST00000299218.1 ENSMUSG00000121735 ENSMUST00000299218.1 ENSMUSG00000121735 (from geneSymbol) uc334krh.1 uc334krh.1 
ENSMUST00000299222.1 Gm31502 ENSMUST00000299222.1 Gm31502 (from geneSymbol) uc334krl.1 uc334krl.1 
ENSMUST00000299231.1 ENSMUSG00000130344 ENSMUST00000299231.1 ENSMUSG00000130344 (from geneSymbol) uc334kru.1 uc334kru.1 
ENSMUST00000299235.1 ENSMUSG00000130345 ENSMUST00000299235.1 ENSMUSG00000130345 (from geneSymbol) uc334kry.1 uc334kry.1 
ENSMUST00000299238.1 ENSMUSG00000130346 ENSMUST00000299238.1 predicted gene 10699 (from RefSeq NR_188804.1) NR_188804 uc334ksb.1 uc334ksb.1 
ENSMUST00000299241.1 ENSMUSG00000130347 ENSMUST00000299241.1 ENSMUSG00000130347 (from geneSymbol) uc334kse.1 uc334kse.1 
ENSMUST00000299252.1 5330429C05Rik ENSMUST00000299252.1 5330429C05Rik (from geneSymbol) AK019918 uc334ksp.1 uc334ksp.1 
ENSMUST00000299256.1 ENSMUSG00000130348 ENSMUST00000299256.1 ENSMUSG00000130348 (from geneSymbol) uc334kst.1 uc334kst.1 
ENSMUST00000299257.1 1700039O17Rik ENSMUST00000299257.1 1700039O17Rik (from geneSymbol) uc334ksu.1 uc334ksu.1 
ENSMUST00000299269.1 ENSMUSG00000130349 ENSMUST00000299269.1 ENSMUSG00000130349 (from geneSymbol) uc334ktg.1 uc334ktg.1 
ENSMUST00000299270.1 ENSMUSG00000130350 ENSMUST00000299270.1 ENSMUSG00000130350 (from geneSymbol) uc334kth.1 uc334kth.1 
ENSMUST00000299271.1 ENSMUSG00000130351 ENSMUST00000299271.1 ENSMUSG00000130351 (from geneSymbol) uc334kti.1 uc334kti.1 
ENSMUST00000299272.1 ENSMUSG00000130352 ENSMUST00000299272.1 ENSMUSG00000130352 (from geneSymbol) uc334ktj.1 uc334ktj.1 
ENSMUST00000299274.1 ENSMUSG00000130353 ENSMUST00000299274.1 ENSMUSG00000130353 (from geneSymbol) uc334ktl.1 uc334ktl.1 
ENSMUST00000299275.1 ENSMUSG00000130354 ENSMUST00000299275.1 ENSMUSG00000130354 (from geneSymbol) uc334ktm.1 uc334ktm.1 
ENSMUST00000299277.1 ENSMUSG00000130355 ENSMUST00000299277.1 ENSMUSG00000130355 (from geneSymbol) uc334kto.1 uc334kto.1 
ENSMUST00000299279.1 ENSMUSG00000130357 ENSMUST00000299279.1 ENSMUSG00000130357 (from geneSymbol) uc334ktp.1 uc334ktp.1 
ENSMUST00000299282.1 ENSMUSG00000130358 ENSMUST00000299282.1 ENSMUSG00000130358 (from geneSymbol) uc334kts.1 uc334kts.1 
ENSMUST00000299286.1 ENSMUSG00000130359 ENSMUST00000299286.1 ENSMUSG00000130359 (from geneSymbol) uc334ktw.1 uc334ktw.1 
ENSMUST00000299292.1 Gm41639 ENSMUST00000299292.1 Gm41639 (from geneSymbol) uc334kuc.1 uc334kuc.1 
ENSMUST00000299295.1 ENSMUSG00000130360 ENSMUST00000299295.1 ENSMUSG00000130360 (from geneSymbol) uc334kuf.1 uc334kuf.1 
ENSMUST00000299296.1 ENSMUSG00000130361 ENSMUST00000299296.1 ENSMUSG00000130361 (from geneSymbol) uc334kug.1 uc334kug.1 
ENSMUST00000299297.1 ENSMUSG00000130362 ENSMUST00000299297.1 ENSMUSG00000130362 (from geneSymbol) uc334kuh.1 uc334kuh.1 
ENSMUST00000299298.1 ENSMUSG00000130363 ENSMUST00000299298.1 ENSMUSG00000130363 (from geneSymbol) uc334kui.1 uc334kui.1 
ENSMUST00000299300.1 5530601H04Rik ENSMUST00000299300.1 5530601H04Rik (from geneSymbol) KY468256 uc334kuk.1 uc334kuk.1 
ENSMUST00000299399.1 ENSMUSG00000130364 ENSMUST00000299399.1 ENSMUSG00000130364 (from geneSymbol) uc334kyf.1 uc334kyf.1 
ENSMUST00000299400.1 ENSMUSG00000130365 ENSMUST00000299400.1 ENSMUSG00000130365 (from geneSymbol) uc334kyg.1 uc334kyg.1 
ENSMUST00000299404.1 Eldr ENSMUST00000299404.1 Eldr (from geneSymbol) AK015657 uc334kyk.1 uc334kyk.1 
ENSMUST00000299453.1 ENSMUSG00000130366 ENSMUST00000299453.1 ENSMUSG00000130366 (from geneSymbol) uc334lah.1 uc334lah.1 
ENSMUST00000299464.1 ENSMUSG00000130367 ENSMUST00000299464.1 ENSMUSG00000130367 (from geneSymbol) uc334las.1 uc334las.1 
ENSMUST00000299467.1 ENSMUSG00000130368 ENSMUST00000299467.1 ENSMUSG00000130368 (from geneSymbol) BC100413 uc334lav.1 uc334lav.1 
ENSMUST00000299468.1 ENSMUSG00000130369 ENSMUST00000299468.1 ENSMUSG00000130369 (from geneSymbol) uc334law.1 uc334law.1 
ENSMUST00000299473.1 ENSMUSG00000130370 ENSMUST00000299473.1 ENSMUSG00000130370 (from geneSymbol) uc334lbb.1 uc334lbb.1 
ENSMUST00000299474.1 ENSMUSG00000130371 ENSMUST00000299474.1 ENSMUSG00000130371 (from geneSymbol) uc334lbc.1 uc334lbc.1 
ENSMUST00000299475.1 ENSMUSG00000130372 ENSMUST00000299475.1 ENSMUSG00000130372 (from geneSymbol) uc334lbd.1 uc334lbd.1 
ENSMUST00000299476.1 ENSMUSG00000130373 ENSMUST00000299476.1 ENSMUSG00000130373 (from geneSymbol) uc334lbe.1 uc334lbe.1 
ENSMUST00000299482.1 ENSMUSG00000130374 ENSMUST00000299482.1 ENSMUSG00000130374 (from geneSymbol) uc334lbk.1 uc334lbk.1 
ENSMUST00000299486.1 ENSMUSG00000130375 ENSMUST00000299486.1 ENSMUSG00000130375 (from geneSymbol) uc334lbo.1 uc334lbo.1 
ENSMUST00000299519.1 Gm36435 ENSMUST00000299519.1 Gm36435 (from geneSymbol) uc334lcv.1 uc334lcv.1 
ENSMUST00000299524.1 ENSMUSG00000130376 ENSMUST00000299524.1 ENSMUSG00000130376 (from geneSymbol) uc334lda.1 uc334lda.1 
ENSMUST00000299525.1 ENSMUSG00000130377 ENSMUST00000299525.1 ENSMUSG00000130377 (from geneSymbol) uc334ldb.1 uc334ldb.1 
ENSMUST00000299528.1 ENSMUSG00000130378 ENSMUST00000299528.1 ENSMUSG00000130378 (from geneSymbol) uc334lde.1 uc334lde.1 
ENSMUST00000299531.1 Gm31933 ENSMUST00000299531.1 Gm31933 (from geneSymbol) uc334ldh.1 uc334ldh.1 
ENSMUST00000299544.1 ENSMUSG00000130379 ENSMUST00000299544.1 ENSMUSG00000130379 (from geneSymbol) uc334ldu.1 uc334ldu.1 
ENSMUST00000299545.1 Gm42997 ENSMUST00000299545.1 Gm42997 (from geneSymbol) uc334ldv.1 uc334ldv.1 
ENSMUST00000299547.1 ENSMUSG00000130380 ENSMUST00000299547.1 ENSMUSG00000130380 (from geneSymbol) uc334ldx.1 uc334ldx.1 
ENSMUST00000299550.1 ENSMUSG00000130381 ENSMUST00000299550.1 ENSMUSG00000130381 (from geneSymbol) uc334lea.1 uc334lea.1 
ENSMUST00000299554.1 ENSMUSG00000130382 ENSMUST00000299554.1 ENSMUSG00000130382 (from geneSymbol) uc334lee.1 uc334lee.1 
ENSMUST00000299561.1 Gm30931 ENSMUST00000299561.1 Gm30931 (from geneSymbol) uc334lel.1 uc334lel.1 
ENSMUST00000299609.1 ENSMUSG00000130383 ENSMUST00000299609.1 ENSMUSG00000130383 (from geneSymbol) uc334lgf.1 uc334lgf.1 
ENSMUST00000299610.1 ENSMUSG00000130384 ENSMUST00000299610.1 ENSMUSG00000130384 (from geneSymbol) uc334lgg.1 uc334lgg.1 
ENSMUST00000299615.1 ENSMUSG00000130385 ENSMUST00000299615.1 ENSMUSG00000130385 (from geneSymbol) uc334lgl.1 uc334lgl.1 
ENSMUST00000299620.1 4930526F13Rik ENSMUST00000299620.1 4930526F13Rik (from geneSymbol) AK015900 uc334lgq.1 uc334lgq.1 
ENSMUST00000299630.1 ENSMUSG00000130386 ENSMUST00000299630.1 ENSMUSG00000130386 (from geneSymbol) uc334lha.1 uc334lha.1 
ENSMUST00000299633.1 ENSMUSG00000130387 ENSMUST00000299633.1 ENSMUSG00000130387 (from geneSymbol) uc334lhd.1 uc334lhd.1 
ENSMUST00000299634.1 ENSMUSG00000130388 ENSMUST00000299634.1 ENSMUSG00000130388 (from geneSymbol) uc334lhe.1 uc334lhe.1 
ENSMUST00000299635.1 ENSMUSG00000130389 ENSMUST00000299635.1 ENSMUSG00000130389 (from geneSymbol) uc334lhf.1 uc334lhf.1 
ENSMUST00000299637.1 ENSMUSG00000130390 ENSMUST00000299637.1 ENSMUSG00000130390 (from geneSymbol) uc334lhh.1 uc334lhh.1 
ENSMUST00000299638.1 ENSMUSG00000130391 ENSMUST00000299638.1 ENSMUSG00000130391 (from geneSymbol) uc334lhi.1 uc334lhi.1 
ENSMUST00000299639.1 ENSMUSG00000130392 ENSMUST00000299639.1 ENSMUSG00000130392 (from geneSymbol) uc334lhj.1 uc334lhj.1 
ENSMUST00000299641.1 ENSMUSG00000130393 ENSMUST00000299641.1 ENSMUSG00000130393 (from geneSymbol) uc334lhl.1 uc334lhl.1 
ENSMUST00000299642.1 ENSMUSG00000130394 ENSMUST00000299642.1 ENSMUSG00000130394 (from geneSymbol) uc334lhm.1 uc334lhm.1 
ENSMUST00000299644.1 ENSMUSG00000130395 ENSMUST00000299644.1 ENSMUSG00000130395 (from geneSymbol) uc334lho.1 uc334lho.1 
ENSMUST00000299645.1 ENSMUSG00000130396 ENSMUST00000299645.1 ENSMUSG00000130396 (from geneSymbol) uc334lhp.1 uc334lhp.1 
ENSMUST00000299646.1 ENSMUSG00000130397 ENSMUST00000299646.1 ENSMUSG00000130397 (from geneSymbol) uc334lhq.1 uc334lhq.1 
ENSMUST00000299647.1 ENSMUSG00000130398 ENSMUST00000299647.1 ENSMUSG00000130398 (from geneSymbol) uc334lhr.1 uc334lhr.1 
ENSMUST00000299648.1 ENSMUSG00000130399 ENSMUST00000299648.1 ENSMUSG00000130399 (from geneSymbol) uc334lhs.1 uc334lhs.1 
ENSMUST00000299652.1 ENSMUSG00000130400 ENSMUST00000299652.1 ENSMUSG00000130400 (from geneSymbol) uc334lhw.1 uc334lhw.1 
ENSMUST00000299659.1 Gm41638 ENSMUST00000299659.1 Gm41638 (from geneSymbol) uc334lid.1 uc334lid.1 
ENSMUST00000299663.1 ENSMUSG00000130401 ENSMUST00000299663.1 ENSMUSG00000130401 (from geneSymbol) uc334lih.1 uc334lih.1 
ENSMUST00000299664.1 ENSMUSG00000130402 ENSMUST00000299664.1 ENSMUSG00000130402 (from geneSymbol) uc334lii.1 uc334lii.1 
ENSMUST00000299665.1 ENSMUSG00000130403 ENSMUST00000299665.1 ENSMUSG00000130403 (from geneSymbol) uc334lij.1 uc334lij.1 
ENSMUST00000299666.1 ENSMUSG00000130404 ENSMUST00000299666.1 ENSMUSG00000130404 (from geneSymbol) uc334lik.1 uc334lik.1 
ENSMUST00000299669.1 ENSMUSG00000130405 ENSMUST00000299669.1 ENSMUSG00000130405 (from geneSymbol) uc334lin.1 uc334lin.1 
ENSMUST00000299670.1 ENSMUSG00000130406 ENSMUST00000299670.1 ENSMUSG00000130406 (from geneSymbol) uc334lio.1 uc334lio.1 
ENSMUST00000299672.1 ENSMUSG00000130407 ENSMUST00000299672.1 ENSMUSG00000130407 (from geneSymbol) uc334liq.1 uc334liq.1 
ENSMUST00000299674.1 ENSMUSG00000130408 ENSMUST00000299674.1 ENSMUSG00000130408 (from geneSymbol) LF203233 uc334lis.1 uc334lis.1 
ENSMUST00000299675.1 ENSMUSG00000130409 ENSMUST00000299675.1 ENSMUSG00000130409 (from geneSymbol) uc334lit.1 uc334lit.1 
ENSMUST00000299677.1 1700116B05Rik ENSMUST00000299677.1 1700116B05Rik (from geneSymbol) AK018963 uc334liv.1 uc334liv.1 
ENSMUST00000299682.1 ENSMUSG00000130410 ENSMUST00000299682.1 ENSMUSG00000130410 (from geneSymbol) uc334lja.1 uc334lja.1 
ENSMUST00000299683.1 ENSMUSG00000130411 ENSMUST00000299683.1 ENSMUSG00000130411 (from geneSymbol) uc334ljb.1 uc334ljb.1 
ENSMUST00000299684.1 ENSMUSG00000130412 ENSMUST00000299684.1 ENSMUSG00000130412 (from geneSymbol) uc334ljc.1 uc334ljc.1 
ENSMUST00000299685.1 ENSMUSG00000130413 ENSMUST00000299685.1 ENSMUSG00000130413 (from geneSymbol) uc334ljd.1 uc334ljd.1 
ENSMUST00000299686.1 ENSMUSG00000130414 ENSMUST00000299686.1 ENSMUSG00000130414 (from geneSymbol) uc334lje.1 uc334lje.1 
ENSMUST00000299688.1 ENSMUSG00000130415 ENSMUST00000299688.1 ENSMUSG00000130415 (from geneSymbol) uc334ljg.1 uc334ljg.1 
ENSMUST00000299689.1 ENSMUSG00000130416 ENSMUST00000299689.1 ENSMUSG00000130416 (from geneSymbol) uc334ljh.1 uc334ljh.1 
ENSMUST00000299690.1 ENSMUSG00000130417 ENSMUST00000299690.1 ENSMUSG00000130417 (from geneSymbol) uc334lji.1 uc334lji.1 
ENSMUST00000299692.1 ENSMUSG00000130418 ENSMUST00000299692.1 ENSMUSG00000130418 (from geneSymbol) uc334ljk.1 uc334ljk.1 
ENSMUST00000299693.1 ENSMUSG00000130419 ENSMUST00000299693.1 ENSMUSG00000130419 (from geneSymbol) uc334ljl.1 uc334ljl.1 
ENSMUST00000299694.1 Gm11423 ENSMUST00000299694.1 Gm11423 (from geneSymbol) KY467598 uc334ljm.1 uc334ljm.1 
ENSMUST00000299698.1 ENSMUSG00000130420 ENSMUST00000299698.1 ENSMUSG00000130420 (from geneSymbol) BC024416 uc334ljq.1 uc334ljq.1 
ENSMUST00000299703.1 ENSMUSG00000130421 ENSMUST00000299703.1 ENSMUSG00000130421 (from geneSymbol) uc334ljv.1 uc334ljv.1 
ENSMUST00000299706.1 ENSMUSG00000130422 ENSMUST00000299706.1 ENSMUSG00000130422 (from geneSymbol) uc334ljy.1 uc334ljy.1 
ENSMUST00000299709.1 ENSMUSG00000130423 ENSMUST00000299709.1 ENSMUSG00000130423 (from geneSymbol) uc334lkb.1 uc334lkb.1 
ENSMUST00000299711.1 ENSMUSG00000130424 ENSMUST00000299711.1 ENSMUSG00000130424 (from geneSymbol) uc334lkd.1 uc334lkd.1 
ENSMUST00000299724.1 4632428C04Rik ENSMUST00000299724.1 4632428C04Rik (from geneSymbol) AK085759 uc334lkq.1 uc334lkq.1 
ENSMUST00000299745.1 Gm42397 ENSMUST00000299745.1 Gm42397 (from geneSymbol) uc334lll.1 uc334lll.1 
ENSMUST00000299749.1 ENSMUSG00000130425 ENSMUST00000299749.1 ENSMUSG00000130425 (from geneSymbol) uc334llp.1 uc334llp.1 
ENSMUST00000299752.1 Gm44145 ENSMUST00000299752.1 Gm44145 (from geneSymbol) uc334lls.1 uc334lls.1 
ENSMUST00000299767.1 ENSMUSG00000130426 ENSMUST00000299767.1 ENSMUSG00000130426 (from geneSymbol) uc334lmh.1 uc334lmh.1 
ENSMUST00000299769.1 ENSMUSG00000130427 ENSMUST00000299769.1 ENSMUSG00000130427 (from geneSymbol) uc334lmj.1 uc334lmj.1 
ENSMUST00000299770.1 ENSMUSG00000130428 ENSMUST00000299770.1 ENSMUSG00000130428 (from geneSymbol) uc334lmk.1 uc334lmk.1 
ENSMUST00000299771.1 Gm31690 ENSMUST00000299771.1 Gm31690 (from geneSymbol) uc334lml.1 uc334lml.1 
ENSMUST00000299784.1 ENSMUSG00000130430 ENSMUST00000299784.1 ENSMUSG00000130430 (from geneSymbol) uc334lmy.1 uc334lmy.1 
ENSMUST00000299796.1 ENSMUSG00000130431 ENSMUST00000299796.1 ENSMUSG00000130431 (from geneSymbol) uc334lni.1 uc334lni.1 
ENSMUST00000299801.1 ENSMUSG00000130432 ENSMUST00000299801.1 ENSMUSG00000130432 (from geneSymbol) uc334lnn.1 uc334lnn.1 
ENSMUST00000299808.1 ENSMUSG00000130433 ENSMUST00000299808.1 ENSMUSG00000130433 (from geneSymbol) uc334lnu.1 uc334lnu.1 
ENSMUST00000299809.1 ENSMUSG00000130434 ENSMUST00000299809.1 ENSMUSG00000130434 (from geneSymbol) uc334lnv.1 uc334lnv.1 
ENSMUST00000299811.1 ENSMUSG00000130435 ENSMUST00000299811.1 ENSMUSG00000130435 (from geneSymbol) uc334lnx.1 uc334lnx.1 
ENSMUST00000299816.1 Gm21114 ENSMUST00000299816.1 Gm21114 (from geneSymbol) uc334loc.1 uc334loc.1 
ENSMUST00000299828.1 ENSMUSG00000130437 ENSMUST00000299828.1 ENSMUSG00000130437 (from geneSymbol) uc334loo.1 uc334loo.1 
ENSMUST00000299830.1 ENSMUSG00000130438 ENSMUST00000299830.1 ENSMUSG00000130438 (from geneSymbol) uc334loq.1 uc334loq.1 
ENSMUST00000299833.1 ENSMUSG00000130439 ENSMUST00000299833.1 ENSMUSG00000130439 (from geneSymbol) uc334lot.1 uc334lot.1 
ENSMUST00000299836.1 ENSMUSG00000130440 ENSMUST00000299836.1 ENSMUSG00000130440 (from geneSymbol) uc334low.1 uc334low.1 
ENSMUST00000299837.1 ENSMUSG00000130441 ENSMUST00000299837.1 ENSMUSG00000130441 (from geneSymbol) uc334lox.1 uc334lox.1 
ENSMUST00000299839.1 ENSMUSG00000130442 ENSMUST00000299839.1 ENSMUSG00000130442 (from geneSymbol) uc334loz.1 uc334loz.1 
ENSMUST00000299847.1 ENSMUSG00000130443 ENSMUST00000299847.1 ENSMUSG00000130443 (from geneSymbol) uc334lph.1 uc334lph.1 
ENSMUST00000299848.1 ENSMUSG00000130444 ENSMUST00000299848.1 ENSMUSG00000130444 (from geneSymbol) uc334lpi.1 uc334lpi.1 
ENSMUST00000299850.1 ENSMUSG00000130445 ENSMUST00000299850.1 ENSMUSG00000130445 (from geneSymbol) uc334lpk.1 uc334lpk.1 
ENSMUST00000299851.1 Gm50106 ENSMUST00000299851.1 Gm50106 (from geneSymbol) uc334lpl.1 uc334lpl.1 
ENSMUST00000299853.1 ENSMUSG00000130446 ENSMUST00000299853.1 ENSMUSG00000130446 (from geneSymbol) uc334lpn.1 uc334lpn.1 
ENSMUST00000299854.1 H19 ENSMUST00000299854.1 H19, imprinted maternally expressed transcript (non-protein coding) (from HGNC H19) AK145379 uc334lpo.1 uc334lpo.1 
ENSMUST00000299859.1 Gm36827 ENSMUST00000299859.1 Gm36827 (from geneSymbol) uc334lpt.1 uc334lpt.1 
ENSMUST00000299878.1 ENSMUSG00000130448 ENSMUST00000299878.1 ENSMUSG00000130448 (from geneSymbol) uc334lql.1 uc334lql.1 
ENSMUST00000299883.1 ENSMUSG00000130449 ENSMUST00000299883.1 ENSMUSG00000130449 (from geneSymbol) uc334lqq.1 uc334lqq.1 
ENSMUST00000299886.1 ENSMUSG00000130450 ENSMUST00000299886.1 ENSMUSG00000130450 (from geneSymbol) uc334lqt.1 uc334lqt.1 
ENSMUST00000299890.1 ENSMUSG00000130451 ENSMUST00000299890.1 ENSMUSG00000130451 (from geneSymbol) uc334lqx.1 uc334lqx.1 
ENSMUST00000299893.1 ENSMUSG00000130452 ENSMUST00000299893.1 ENSMUSG00000130452 (from geneSymbol) uc334lra.1 uc334lra.1 
ENSMUST00000299900.1 ENSMUSG00000130453 ENSMUST00000299900.1 ENSMUSG00000130453 (from geneSymbol) uc334lrh.1 uc334lrh.1 
ENSMUST00000299904.1 ENSMUSG00000130455 ENSMUST00000299904.1 ENSMUSG00000130455 (from geneSymbol) uc334lrk.1 uc334lrk.1 
ENSMUST00000299906.1 ENSMUSG00000130456 ENSMUST00000299906.1 ENSMUSG00000130456 (from geneSymbol) uc334lrm.1 uc334lrm.1 
ENSMUST00000299908.1 ENSMUSG00000130457 ENSMUST00000299908.1 ENSMUSG00000130457 (from geneSymbol) uc334lro.1 uc334lro.1 
ENSMUST00000299909.1 ENSMUSG00000130458 ENSMUST00000299909.1 ENSMUSG00000130458 (from geneSymbol) uc334lrp.1 uc334lrp.1 
ENSMUST00000299911.1 ENSMUSG00000130459 ENSMUST00000299911.1 ENSMUSG00000130459 (from geneSymbol) uc334lrr.1 uc334lrr.1 
ENSMUST00000299913.1 ENSMUSG00000130460 ENSMUST00000299913.1 ENSMUSG00000130460 (from geneSymbol) uc334lrt.1 uc334lrt.1 
ENSMUST00000299914.1 ENSMUSG00000130461 ENSMUST00000299914.1 ENSMUSG00000130461 (from geneSymbol) uc334lru.1 uc334lru.1 
ENSMUST00000299915.1 ENSMUSG00000130462 ENSMUST00000299915.1 ENSMUSG00000130462 (from geneSymbol) uc334lrv.1 uc334lrv.1 
ENSMUST00000299916.1 Gm36011 ENSMUST00000299916.1 Gm36011 (from geneSymbol) AK030228 uc334lrw.1 uc334lrw.1 
ENSMUST00000299919.1 ENSMUSG00000130463 ENSMUST00000299919.1 ENSMUSG00000130463 (from geneSymbol) uc334lrz.1 uc334lrz.1 
ENSMUST00000299920.1 ENSMUSG00000130464 ENSMUST00000299920.1 ENSMUSG00000130464 (from geneSymbol) uc334lsa.1 uc334lsa.1 
ENSMUST00000299921.1 ENSMUSG00000130465 ENSMUST00000299921.1 ENSMUSG00000130465 (from geneSymbol) uc334lsb.1 uc334lsb.1 
ENSMUST00000299923.1 ENSMUSG00000130466 ENSMUST00000299923.1 ENSMUSG00000130466 (from geneSymbol) uc334lsd.1 uc334lsd.1 
ENSMUST00000299924.1 ENSMUSG00000130467 ENSMUST00000299924.1 ENSMUSG00000130467 (from geneSymbol) uc334lse.1 uc334lse.1 
ENSMUST00000299927.1 Gm6961 ENSMUST00000299927.1 Gm6961 (from geneSymbol) AK153831 uc334lsh.1 uc334lsh.1 
ENSMUST00000299943.1 ENSMUSG00000130468 ENSMUST00000299943.1 ENSMUSG00000130468 (from geneSymbol) uc334lsx.1 uc334lsx.1 
ENSMUST00000299946.1 ENSMUSG00000130469 ENSMUST00000299946.1 ENSMUSG00000130469 (from geneSymbol) uc334lta.1 uc334lta.1 
ENSMUST00000299950.1 ENSMUSG00000130470 ENSMUST00000299950.1 ENSMUSG00000130470 (from geneSymbol) uc334lte.1 uc334lte.1 
ENSMUST00000299951.1 ENSMUSG00000130471 ENSMUST00000299951.1 ENSMUSG00000130471 (from geneSymbol) uc334ltf.1 uc334ltf.1 
ENSMUST00000299954.1 ENSMUSG00000130472 ENSMUST00000299954.1 ENSMUSG00000130472 (from geneSymbol) uc334lti.1 uc334lti.1 
ENSMUST00000299956.1 ENSMUSG00000130473 ENSMUST00000299956.1 ENSMUSG00000130473 (from geneSymbol) uc334ltk.1 uc334ltk.1 
ENSMUST00000299967.1 Gm35162 ENSMUST00000299967.1 Gm35162 (from geneSymbol) uc334ltv.1 uc334ltv.1 
ENSMUST00000299968.1 ENSMUSG00000130474 ENSMUST00000299968.1 ENSMUSG00000130474 (from geneSymbol) uc334ltw.1 uc334ltw.1 
ENSMUST00000299969.1 Gm57321 ENSMUST00000299969.1 Gm57321 (from geneSymbol) uc334ltx.1 uc334ltx.1 
ENSMUST00000299970.1 ENSMUSG00000130475 ENSMUST00000299970.1 ENSMUSG00000130475 (from geneSymbol) BC065400 uc334lty.1 uc334lty.1 
ENSMUST00000299971.1 ENSMUSG00000130476 ENSMUST00000299971.1 ENSMUSG00000130476 (from geneSymbol) uc334ltz.1 uc334ltz.1 
ENSMUST00000299972.1 ENSMUSG00000130477 ENSMUST00000299972.1 ENSMUSG00000130477 (from geneSymbol) uc334lua.1 uc334lua.1 
ENSMUST00000299974.1 4930519L02Rik ENSMUST00000299974.1 4930519L02Rik (from geneSymbol) uc334luc.1 uc334luc.1 
ENSMUST00000300054.1 ENSMUSG00000130478 ENSMUST00000300054.1 ENSMUSG00000130478 (from geneSymbol) uc334lxe.1 uc334lxe.1 
ENSMUST00000300121.1 ENSMUSG00000130479 ENSMUST00000300121.1 ENSMUSG00000130479 (from geneSymbol) uc334lzr.1 uc334lzr.1 
ENSMUST00000300123.1 Gm47658 ENSMUST00000300123.1 Gm47658 (from geneSymbol) uc334lzt.1 uc334lzt.1 
ENSMUST00000300126.1 BC016548 ENSMUST00000300126.1 BC016548 (from geneSymbol) BC096650 uc334lzw.1 uc334lzw.1 
ENSMUST00000300130.1 ENSMUSG00000130480 ENSMUST00000300130.1 ENSMUSG00000130480 (from geneSymbol) uc334maa.1 uc334maa.1 
ENSMUST00000300131.1 ENSMUSG00000130481 ENSMUST00000300131.1 ENSMUSG00000130481 (from geneSymbol) uc334mab.1 uc334mab.1 
ENSMUST00000300132.1 ENSMUSG00000130482 ENSMUST00000300132.1 ENSMUSG00000130482 (from geneSymbol) uc334mac.1 uc334mac.1 
ENSMUST00000300133.1 ENSMUSG00000130483 ENSMUST00000300133.1 ENSMUSG00000130483 (from geneSymbol) uc334mad.1 uc334mad.1 
ENSMUST00000300134.1 ENSMUSG00000130484 ENSMUST00000300134.1 ENSMUSG00000130484 (from geneSymbol) uc334mae.1 uc334mae.1 
ENSMUST00000300135.1 ENSMUSG00000130485 ENSMUST00000300135.1 ENSMUSG00000130485 (from geneSymbol) uc334maf.1 uc334maf.1 
ENSMUST00000300137.1 ENSMUSG00000130486 ENSMUST00000300137.1 ENSMUSG00000130486 (from geneSymbol) uc334mah.1 uc334mah.1 
ENSMUST00000300145.1 ENSMUSG00000130487 ENSMUST00000300145.1 ENSMUSG00000130487 (from geneSymbol) uc334map.1 uc334map.1 
ENSMUST00000300149.1 ENSMUSG00000130488 ENSMUST00000300149.1 ENSMUSG00000130488 (from geneSymbol) uc334mat.1 uc334mat.1 
ENSMUST00000300161.1 ENSMUSG00000130489 ENSMUST00000300161.1 ENSMUSG00000130489 (from geneSymbol) uc334mbf.1 uc334mbf.1 
ENSMUST00000300164.1 ENSMUSG00000130490 ENSMUST00000300164.1 ENSMUSG00000130490 (from geneSymbol) uc334mbi.1 uc334mbi.1 
ENSMUST00000300165.1 ENSMUSG00000130491 ENSMUST00000300165.1 ENSMUSG00000130491 (from geneSymbol) uc334mbj.1 uc334mbj.1 
ENSMUST00000300166.1 ENSMUSG00000130492 ENSMUST00000300166.1 ENSMUSG00000130492 (from geneSymbol) uc334mbk.1 uc334mbk.1 
ENSMUST00000300167.1 ENSMUSG00000130493 ENSMUST00000300167.1 ENSMUSG00000130493 (from geneSymbol) uc334mbl.1 uc334mbl.1 
ENSMUST00000300168.1 ENSMUSG00000130494 ENSMUST00000300168.1 ENSMUSG00000130494 (from geneSymbol) uc334mbm.1 uc334mbm.1 
ENSMUST00000300169.1 ENSMUSG00000130495 ENSMUST00000300169.1 ENSMUSG00000130495 (from geneSymbol) uc334mbn.1 uc334mbn.1 
ENSMUST00000300184.1 ENSMUSG00000130496 ENSMUST00000300184.1 ENSMUSG00000130496 (from geneSymbol) uc334mcc.1 uc334mcc.1 
ENSMUST00000300186.1 5830416I19Rik ENSMUST00000300186.1 5830416I19Rik (from geneSymbol) uc334mce.1 uc334mce.1 
ENSMUST00000300192.1 Uckl1os ENSMUST00000300192.1 Uckl1os (from geneSymbol) AK039436 uc334mcg.1 uc334mcg.1 
ENSMUST00000300194.1 ENSMUSG00000130497 ENSMUST00000300194.1 ENSMUSG00000130497 (from geneSymbol) uc334mci.1 uc334mci.1 
ENSMUST00000300195.1 ENSMUSG00000130498 ENSMUST00000300195.1 ENSMUSG00000130498 (from geneSymbol) uc334mcj.1 uc334mcj.1 
ENSMUST00000300210.1 ENSMUSG00000130499 ENSMUST00000300210.1 ENSMUSG00000130499 (from geneSymbol) uc334mcy.1 uc334mcy.1 
ENSMUST00000300211.1 ENSMUSG00000130500 ENSMUST00000300211.1 ENSMUSG00000130500 (from geneSymbol) uc334mcz.1 uc334mcz.1 
ENSMUST00000300212.1 ENSMUSG00000130501 ENSMUST00000300212.1 ENSMUSG00000130501 (from geneSymbol) uc334mda.1 uc334mda.1 
ENSMUST00000300214.1 ENSMUSG00000130502 ENSMUST00000300214.1 ENSMUSG00000130502 (from geneSymbol) uc334mdc.1 uc334mdc.1 
ENSMUST00000300218.1 ENSMUSG00000130503 ENSMUST00000300218.1 ENSMUSG00000130503 (from geneSymbol) uc334mdg.1 uc334mdg.1 
ENSMUST00000300219.1 Gm11496 ENSMUST00000300219.1 Gm11496 (from geneSymbol) uc334mdh.1 uc334mdh.1 
ENSMUST00000300223.1 ENSMUSG00000130504 ENSMUST00000300223.1 ENSMUSG00000130504 (from geneSymbol) uc334mdl.1 uc334mdl.1 
ENSMUST00000300227.1 ENSMUSG00000130505 ENSMUST00000300227.1 ENSMUSG00000130505 (from geneSymbol) uc334mdp.1 uc334mdp.1 
ENSMUST00000300228.1 ENSMUSG00000130506 ENSMUST00000300228.1 ENSMUSG00000130506 (from geneSymbol) uc334mdq.1 uc334mdq.1 
ENSMUST00000300230.1 ENSMUSG00000130507 ENSMUST00000300230.1 ENSMUSG00000130507 (from geneSymbol) uc334mds.1 uc334mds.1 
ENSMUST00000300231.1 ENSMUSG00000130508 ENSMUST00000300231.1 ENSMUSG00000130508 (from geneSymbol) uc334mdt.1 uc334mdt.1 
ENSMUST00000300232.1 ENSMUSG00000130509 ENSMUST00000300232.1 ENSMUSG00000130509 (from geneSymbol) uc334mdu.1 uc334mdu.1 
ENSMUST00000300233.1 ENSMUSG00000130510 ENSMUST00000300233.1 ENSMUSG00000130510 (from geneSymbol) uc334mdv.1 uc334mdv.1 
ENSMUST00000300235.1 ENSMUSG00000130511 ENSMUST00000300235.1 ENSMUSG00000130511 (from geneSymbol) uc334mdx.1 uc334mdx.1 
ENSMUST00000300236.1 ENSMUSG00000130512 ENSMUST00000300236.1 ENSMUSG00000130512 (from geneSymbol) uc334mdy.1 uc334mdy.1 
ENSMUST00000300238.1 ENSMUSG00000130513 ENSMUST00000300238.1 ENSMUSG00000130513 (from geneSymbol) uc334mea.1 uc334mea.1 
ENSMUST00000300242.1 Gm33758 ENSMUST00000300242.1 Gm33758 (from geneSymbol) uc334mee.1 uc334mee.1 
ENSMUST00000300276.1 ENSMUSG00000130514 ENSMUST00000300276.1 ENSMUSG00000130514 (from geneSymbol) uc334mfm.1 uc334mfm.1 
ENSMUST00000300277.1 ENSMUSG00000130515 ENSMUST00000300277.1 ENSMUSG00000130515 (from geneSymbol) uc334mfn.1 uc334mfn.1 
ENSMUST00000300279.1 ENSMUSG00000130516 ENSMUST00000300279.1 ENSMUSG00000130516 (from geneSymbol) uc334mfp.1 uc334mfp.1 
ENSMUST00000300280.1 ENSMUSG00000130517 ENSMUST00000300280.1 ENSMUSG00000130517 (from geneSymbol) uc334mfq.1 uc334mfq.1 
ENSMUST00000300284.1 ENSMUSG00000130518 ENSMUST00000300284.1 ENSMUSG00000130518 (from geneSymbol) uc334mfu.1 uc334mfu.1 
ENSMUST00000300287.1 ENSMUSG00000130519 ENSMUST00000300287.1 ENSMUSG00000130519 (from geneSymbol) uc334mfx.1 uc334mfx.1 
ENSMUST00000300298.1 ENSMUSG00000130520 ENSMUST00000300298.1 ENSMUSG00000130520 (from geneSymbol) uc334mgi.1 uc334mgi.1 
ENSMUST00000300301.1 ENSMUSG00000130521 ENSMUST00000300301.1 ENSMUSG00000130521 (from geneSymbol) uc334mgl.1 uc334mgl.1 
ENSMUST00000300302.1 ENSMUSG00000130522 ENSMUST00000300302.1 ENSMUSG00000130522 (from geneSymbol) uc334mgm.1 uc334mgm.1 
ENSMUST00000300304.1 ENSMUSG00000130523 ENSMUST00000300304.1 ENSMUSG00000130523 (from geneSymbol) uc334mgo.1 uc334mgo.1 
ENSMUST00000300306.1 ENSMUSG00000130525 ENSMUST00000300306.1 ENSMUSG00000130525 (from geneSymbol) uc334mgp.1 uc334mgp.1 
ENSMUST00000300307.1 ENSMUSG00000130526 ENSMUST00000300307.1 ENSMUSG00000130526 (from geneSymbol) AK017073 uc334mgq.1 uc334mgq.1 
ENSMUST00000300308.1 ENSMUSG00000130527 ENSMUST00000300308.1 ENSMUSG00000130527 (from geneSymbol) uc334mgr.1 uc334mgr.1 
ENSMUST00000300309.1 ENSMUSG00000130528 ENSMUST00000300309.1 ENSMUSG00000130528 (from geneSymbol) uc334mgs.1 uc334mgs.1 
ENSMUST00000300311.1 ENSMUSG00000130529 ENSMUST00000300311.1 ENSMUSG00000130529 (from geneSymbol) uc334mgu.1 uc334mgu.1 
ENSMUST00000300312.1 ENSMUSG00000130530 ENSMUST00000300312.1 ENSMUSG00000130530 (from geneSymbol) uc334mgv.1 uc334mgv.1 
ENSMUST00000300315.1 ENSMUSG00000130533 ENSMUST00000300315.1 ENSMUSG00000130533 (from geneSymbol) uc334mgw.1 uc334mgw.1 
ENSMUST00000300316.1 4933438A12Rik ENSMUST00000300316.1 4933438A12Rik (from geneSymbol) AK017105 uc334mgx.1 uc334mgx.1 
ENSMUST00000300323.1 ENSMUSG00000130534 ENSMUST00000300323.1 ENSMUSG00000130534 (from geneSymbol) uc334mhe.1 uc334mhe.1 
ENSMUST00000300330.1 ENSMUSG00000130536 ENSMUST00000300330.1 ENSMUSG00000130536 (from geneSymbol) uc334mhf.1 uc334mhf.1 
ENSMUST00000300332.1 ENSMUSG00000130537 ENSMUST00000300332.1 ENSMUSG00000130537 (from geneSymbol) uc334mhh.1 uc334mhh.1 
ENSMUST00000300335.1 ENSMUSG00000130538 ENSMUST00000300335.1 ENSMUSG00000130538 (from geneSymbol) uc334mhk.1 uc334mhk.1 
ENSMUST00000300338.1 Gm10817 ENSMUST00000300338.1 Gm10817 (from geneSymbol) uc334mhn.1 uc334mhn.1 
ENSMUST00000300355.1 Gm33332 ENSMUST00000300355.1 Gm33332 (from geneSymbol) AK039957 uc334mie.1 uc334mie.1 
ENSMUST00000300356.1 ENSMUSG00000130539 ENSMUST00000300356.1 ENSMUSG00000130539 (from geneSymbol) uc334mif.1 uc334mif.1 
ENSMUST00000300362.1 ENSMUSG00000130540 ENSMUST00000300362.1 ENSMUSG00000130540 (from geneSymbol) uc334mil.1 uc334mil.1 
ENSMUST00000300368.1 ENSMUSG00000130541 ENSMUST00000300368.1 ENSMUSG00000130541 (from geneSymbol) uc334mir.1 uc334mir.1 
ENSMUST00000300383.1 Gm35041 ENSMUST00000300383.1 Gm35041 (from geneSymbol) uc334mjg.1 uc334mjg.1 
ENSMUST00000300414.1 ENSMUSG00000130542 ENSMUST00000300414.1 ENSMUSG00000130542 (from geneSymbol) uc334mkl.1 uc334mkl.1 
ENSMUST00000300417.1 ENSMUSG00000130543 ENSMUST00000300417.1 ENSMUSG00000130543 (from geneSymbol) uc334mko.1 uc334mko.1 
ENSMUST00000300418.1 ENSMUSG00000130544 ENSMUST00000300418.1 ENSMUSG00000130544 (from geneSymbol) uc334mkp.1 uc334mkp.1 
ENSMUST00000300420.1 Gm50271 ENSMUST00000300420.1 Gm50271 (from geneSymbol) AK085533 uc334mkr.1 uc334mkr.1 
ENSMUST00000300430.1 Reno1 ENSMUST00000300430.1 Reno1 (from geneSymbol) AK081626 uc334mlb.1 uc334mlb.1 
ENSMUST00000300446.1 ENSMUSG00000130545 ENSMUST00000300446.1 ENSMUSG00000130545 (from geneSymbol) uc334mlr.1 uc334mlr.1 
ENSMUST00000300449.1 ENSMUSG00000130546 ENSMUST00000300449.1 ENSMUSG00000130546 (from geneSymbol) uc334mlu.1 uc334mlu.1 
ENSMUST00000300451.1 ENSMUSG00000130547 ENSMUST00000300451.1 ENSMUSG00000130547 (from geneSymbol) uc334mlw.1 uc334mlw.1 
ENSMUST00000300452.1 ENSMUSG00000130548 ENSMUST00000300452.1 ENSMUSG00000130548 (from geneSymbol) uc334mlx.1 uc334mlx.1 
ENSMUST00000300453.1 ENSMUSG00000130549 ENSMUST00000300453.1 ENSMUSG00000130549 (from geneSymbol) uc334mly.1 uc334mly.1 
ENSMUST00000300454.1 ENSMUSG00000130550 ENSMUST00000300454.1 ENSMUSG00000130550 (from geneSymbol) uc334mlz.1 uc334mlz.1 
ENSMUST00000300456.1 ENSMUSG00000130551 ENSMUST00000300456.1 ENSMUSG00000130551 (from geneSymbol) uc334mmb.1 uc334mmb.1 
ENSMUST00000300457.1 ENSMUSG00000130552 ENSMUST00000300457.1 ENSMUSG00000130552 (from geneSymbol) uc334mmc.1 uc334mmc.1 
ENSMUST00000300467.1 Gm33651 ENSMUST00000300467.1 Gm33651 (from geneSymbol) uc334mmm.1 uc334mmm.1 
ENSMUST00000300505.1 Gm11973 ENSMUST00000300505.1 Gm11973 (from geneSymbol) uc334mnx.1 uc334mnx.1 
ENSMUST00000300511.1 ENSMUSG00000130553 ENSMUST00000300511.1 ENSMUSG00000130553 (from geneSymbol) uc334mod.1 uc334mod.1 
ENSMUST00000300512.1 ENSMUSG00000130554 ENSMUST00000300512.1 ENSMUSG00000130554 (from geneSymbol) uc334moe.1 uc334moe.1 
ENSMUST00000300513.1 ENSMUSG00000130555 ENSMUST00000300513.1 ENSMUSG00000130555 (from geneSymbol) uc334mof.1 uc334mof.1 
ENSMUST00000300514.1 ENSMUSG00000130556 ENSMUST00000300514.1 ENSMUSG00000130556 (from geneSymbol) uc334mog.1 uc334mog.1 
ENSMUST00000300516.1 ENSMUSG00000130557 ENSMUST00000300516.1 ENSMUSG00000130557 (from geneSymbol) uc334moi.1 uc334moi.1 
ENSMUST00000300517.1 ENSMUSG00000130558 ENSMUST00000300517.1 ENSMUSG00000130558 (from geneSymbol) LF198597 uc334moj.1 uc334moj.1 
ENSMUST00000300518.1 ENSMUSG00000130559 ENSMUST00000300518.1 ENSMUSG00000130559 (from geneSymbol) uc334mok.1 uc334mok.1 
ENSMUST00000300519.1 ENSMUSG00000130560 ENSMUST00000300519.1 ENSMUSG00000130560 (from geneSymbol) uc334mol.1 uc334mol.1 
ENSMUST00000300521.1 ENSMUSG00000130561 ENSMUST00000300521.1 ENSMUSG00000130561 (from geneSymbol) uc334mon.1 uc334mon.1 
ENSMUST00000300522.1 ENSMUSG00000130562 ENSMUST00000300522.1 ENSMUSG00000130562 (from geneSymbol) uc334moo.1 uc334moo.1 
ENSMUST00000300524.1 ENSMUSG00000130563 ENSMUST00000300524.1 ENSMUSG00000130563 (from geneSymbol) uc334moq.1 uc334moq.1 
ENSMUST00000300528.1 ENSMUSG00000130564 ENSMUST00000300528.1 ENSMUSG00000130564 (from geneSymbol) uc334mou.1 uc334mou.1 
ENSMUST00000300529.1 ENSMUSG00000130565 ENSMUST00000300529.1 ENSMUSG00000130565 (from geneSymbol) uc334mov.1 uc334mov.1 
ENSMUST00000300532.1 ENSMUSG00000130566 ENSMUST00000300532.1 ENSMUSG00000130566 (from geneSymbol) uc334moy.1 uc334moy.1 
ENSMUST00000300538.1 ENSMUSG00000130567 ENSMUST00000300538.1 ENSMUSG00000130567 (from geneSymbol) uc334mpe.1 uc334mpe.1 
ENSMUST00000300542.1 ENSMUSG00000130568 ENSMUST00000300542.1 ENSMUSG00000130568 (from geneSymbol) uc334mpi.1 uc334mpi.1 
ENSMUST00000300544.1 ENSMUSG00000130569 ENSMUST00000300544.1 ENSMUSG00000130569 (from geneSymbol) uc334mpk.1 uc334mpk.1 
ENSMUST00000300545.1 ENSMUSG00000130570 ENSMUST00000300545.1 ENSMUSG00000130570 (from geneSymbol) uc334mpl.1 uc334mpl.1 
ENSMUST00000300546.1 ENSMUSG00000130571 ENSMUST00000300546.1 ENSMUSG00000130571 (from geneSymbol) uc334mpm.1 uc334mpm.1 
ENSMUST00000300549.1 ENSMUSG00000130572 ENSMUST00000300549.1 ENSMUSG00000130572 (from geneSymbol) uc334mpp.1 uc334mpp.1 
ENSMUST00000300550.1 ENSMUSG00000130573 ENSMUST00000300550.1 ENSMUSG00000130573 (from geneSymbol) uc334mpq.1 uc334mpq.1 
ENSMUST00000300552.1 ENSMUSG00000130574 ENSMUST00000300552.1 ENSMUSG00000130574 (from geneSymbol) uc334mps.1 uc334mps.1 
ENSMUST00000300562.1 ENSMUSG00000130575 ENSMUST00000300562.1 ENSMUSG00000130575 (from geneSymbol) uc334mqc.1 uc334mqc.1 
ENSMUST00000300565.1 ENSMUSG00000130577 ENSMUST00000300565.1 ENSMUSG00000130577 (from geneSymbol) uc334mqe.1 uc334mqe.1 
ENSMUST00000300578.1 ENSMUSG00000130578 ENSMUST00000300578.1 ENSMUSG00000130578 (from geneSymbol) uc334mqr.1 uc334mqr.1 
ENSMUST00000300580.1 ENSMUSG00000130579 ENSMUST00000300580.1 ENSMUSG00000130579 (from geneSymbol) uc334mqt.1 uc334mqt.1 
ENSMUST00000300581.1 ENSMUSG00000130580 ENSMUST00000300581.1 ENSMUSG00000130580 (from geneSymbol) uc334mqu.1 uc334mqu.1 
ENSMUST00000300588.1 ENSMUSG00000130581 ENSMUST00000300588.1 ENSMUSG00000130581 (from geneSymbol) uc334mrb.1 uc334mrb.1 
ENSMUST00000300596.1 ENSMUSG00000130582 ENSMUST00000300596.1 ENSMUSG00000130582 (from geneSymbol) uc334mrj.1 uc334mrj.1 
ENSMUST00000300598.1 ENSMUSG00000130583 ENSMUST00000300598.1 ENSMUSG00000130583 (from geneSymbol) BC099537 uc334mrl.1 uc334mrl.1 
ENSMUST00000300601.1 ENSMUSG00000130584 ENSMUST00000300601.1 ENSMUSG00000130584 (from geneSymbol) uc334mro.1 uc334mro.1 
ENSMUST00000300603.1 A130051J06Rik ENSMUST00000300603.1 A130051J06Rik (from geneSymbol) AK037810 uc334mrq.1 uc334mrq.1 
ENSMUST00000300613.1 ENSMUSG00000130585 ENSMUST00000300613.1 ENSMUSG00000130585 (from geneSymbol) AK007034 uc334msa.1 uc334msa.1 
ENSMUST00000300614.1 ENSMUSG00000130586 ENSMUST00000300614.1 ENSMUSG00000130586 (from geneSymbol) uc334msb.1 uc334msb.1 
ENSMUST00000300615.1 ENSMUSG00000130587 ENSMUST00000300615.1 ENSMUSG00000130587 (from geneSymbol) uc334msc.1 uc334msc.1 
ENSMUST00000300617.1 ENSMUSG00000130588 ENSMUST00000300617.1 ENSMUSG00000130588 (from geneSymbol) uc334mse.1 uc334mse.1 
ENSMUST00000300618.1 ENSMUSG00000130589 ENSMUST00000300618.1 ENSMUSG00000130589 (from geneSymbol) uc334msf.1 uc334msf.1 
ENSMUST00000300623.1 ENSMUSG00000130590 ENSMUST00000300623.1 ENSMUSG00000130590 (from geneSymbol) uc334msk.1 uc334msk.1 
ENSMUST00000300624.1 ENSMUSG00000130591 ENSMUST00000300624.1 ENSMUSG00000130591 (from geneSymbol) uc334msl.1 uc334msl.1 
ENSMUST00000300628.1 ENSMUSG00000130592 ENSMUST00000300628.1 ENSMUSG00000130592 (from geneSymbol) uc334msp.1 uc334msp.1 
ENSMUST00000300648.1 4930459C07Rik ENSMUST00000300648.1 4930459C07Rik (from geneSymbol) uc334mti.1 uc334mti.1 
ENSMUST00000300671.1 ENSMUSG00000130593 ENSMUST00000300671.1 ENSMUSG00000130593 (from geneSymbol) uc334muf.1 uc334muf.1 
ENSMUST00000300672.1 ENSMUSG00000130594 ENSMUST00000300672.1 ENSMUSG00000130594 (from geneSymbol) uc334mug.1 uc334mug.1 
ENSMUST00000300675.1 ENSMUSG00000130595 ENSMUST00000300675.1 ENSMUSG00000130595 (from geneSymbol) uc334muj.1 uc334muj.1 
ENSMUST00000300676.1 ENSMUSG00000130596 ENSMUST00000300676.1 ENSMUSG00000130596 (from geneSymbol) uc334muk.1 uc334muk.1 
ENSMUST00000300684.1 ENSMUSG00000130597 ENSMUST00000300684.1 ENSMUSG00000130597 (from geneSymbol) uc334mur.1 uc334mur.1 
ENSMUST00000300695.1 ENSMUSG00000130598 ENSMUST00000300695.1 ENSMUSG00000130598 (from geneSymbol) uc334mvc.1 uc334mvc.1 
ENSMUST00000300701.1 ENSMUSG00000130599 ENSMUST00000300701.1 ENSMUSG00000130599 (from geneSymbol) uc334mvi.1 uc334mvi.1 
ENSMUST00000300702.1 ENSMUSG00000130600 ENSMUST00000300702.1 ENSMUSG00000130600 (from geneSymbol) uc334mvj.1 uc334mvj.1 
ENSMUST00000300703.1 ENSMUSG00000130601 ENSMUST00000300703.1 ENSMUSG00000130601 (from geneSymbol) uc334mvk.1 uc334mvk.1 
ENSMUST00000300704.1 ENSMUSG00000130602 ENSMUST00000300704.1 ENSMUSG00000130602 (from geneSymbol) uc334mvl.1 uc334mvl.1 
ENSMUST00000300707.1 ENSMUSG00000130603 ENSMUST00000300707.1 ENSMUSG00000130603 (from geneSymbol) uc334mvo.1 uc334mvo.1 
ENSMUST00000300708.1 ENSMUSG00000130604 ENSMUST00000300708.1 ENSMUSG00000130604 (from geneSymbol) uc334mvp.1 uc334mvp.1 
ENSMUST00000300715.1 ENSMUSG00000130605 ENSMUST00000300715.1 ENSMUSG00000130605 (from geneSymbol) uc334mvw.1 uc334mvw.1 
ENSMUST00000300721.1 Gm41584 ENSMUST00000300721.1 Gm41584 (from geneSymbol) uc334mwc.1 uc334mwc.1 
ENSMUST00000300732.1 ENSMUSG00000130606 ENSMUST00000300732.1 ENSMUSG00000130606 (from geneSymbol) uc334mwn.1 uc334mwn.1 
ENSMUST00000300733.1 ENSMUSG00000130607 ENSMUST00000300733.1 ENSMUSG00000130607 (from geneSymbol) uc334mwo.1 uc334mwo.1 
ENSMUST00000300734.1 ENSMUSG00000130608 ENSMUST00000300734.1 ENSMUSG00000130608 (from geneSymbol) LF195257 uc334mwp.1 uc334mwp.1 
ENSMUST00000300735.1 ENSMUSG00000130609 ENSMUST00000300735.1 ENSMUSG00000130609 (from geneSymbol) uc334mwq.1 uc334mwq.1 
ENSMUST00000300737.1 ENSMUSG00000130610 ENSMUST00000300737.1 ENSMUSG00000130610 (from geneSymbol) uc334mws.1 uc334mws.1 
ENSMUST00000300744.1 ENSMUSG00000130611 ENSMUST00000300744.1 ENSMUSG00000130611 (from geneSymbol) uc334mwz.1 uc334mwz.1 
ENSMUST00000300746.1 ENSMUSG00000130612 ENSMUST00000300746.1 ENSMUSG00000130612 (from geneSymbol) uc334mxb.1 uc334mxb.1 
ENSMUST00000300758.1 4930527F14Rik ENSMUST00000300758.1 4930527F14Rik (from geneSymbol) AK039091 uc334mxn.1 uc334mxn.1 
ENSMUST00000300760.1 ENSMUSG00000130613 ENSMUST00000300760.1 ENSMUSG00000130613 (from geneSymbol) uc334mxp.1 uc334mxp.1 
ENSMUST00000300763.1 ENSMUSG00000130614 ENSMUST00000300763.1 ENSMUSG00000130614 (from geneSymbol) uc334mxs.1 uc334mxs.1 
ENSMUST00000300766.1 ENSMUSG00000130615 ENSMUST00000300766.1 ENSMUSG00000130615 (from geneSymbol) uc334mxv.1 uc334mxv.1 
ENSMUST00000300767.1 Gm46851 ENSMUST00000300767.1 Gm46851 (from geneSymbol) uc334mxw.1 uc334mxw.1 
ENSMUST00000300772.1 1700048P04Rik ENSMUST00000300772.1 1700048P04Rik (from geneSymbol) uc334myb.1 uc334myb.1 
ENSMUST00000300776.1 ENSMUSG00000130616 ENSMUST00000300776.1 ENSMUSG00000130616 (from geneSymbol) uc334myf.1 uc334myf.1 
ENSMUST00000300778.1 ENSMUSG00000130617 ENSMUST00000300778.1 ENSMUSG00000130617 (from geneSymbol) AF357344 uc334myh.1 uc334myh.1 
ENSMUST00000300779.1 ENSMUSG00000130618 ENSMUST00000300779.1 ENSMUSG00000130618 (from geneSymbol) uc334myi.1 uc334myi.1 
ENSMUST00000300783.1 ENSMUSG00000130619 ENSMUST00000300783.1 ENSMUSG00000130619 (from geneSymbol) uc334mym.1 uc334mym.1 
ENSMUST00000300784.1 ENSMUSG00000130620 ENSMUST00000300784.1 ENSMUSG00000130620 (from geneSymbol) uc334myn.1 uc334myn.1 
ENSMUST00000300788.1 ENSMUSG00000130621 ENSMUST00000300788.1 ENSMUSG00000130621 (from geneSymbol) uc334myr.1 uc334myr.1 
ENSMUST00000300789.1 Gm17546 ENSMUST00000300789.1 predicted gene, 17546, transcript variant 2 (from RefSeq NR_155277.1) NR_155277 uc334mys.1 uc334mys.1 
ENSMUST00000300790.1 Gm56943 ENSMUST00000300790.1 Gm56943 (from geneSymbol) uc334myt.1 uc334myt.1 
ENSMUST00000300792.1 ENSMUSG00000130622 ENSMUST00000300792.1 ENSMUSG00000130622 (from geneSymbol) uc334myv.1 uc334myv.1 
ENSMUST00000300801.1 Gm49587 ENSMUST00000300801.1 Gm49587 (from geneSymbol) AK079458 uc334mze.1 uc334mze.1 
ENSMUST00000300809.1 4930535L15Rik ENSMUST00000300809.1 4930535L15Rik (from geneSymbol) AK019721 uc334mzm.1 uc334mzm.1 
ENSMUST00000300828.1 ENSMUSG00000130623 ENSMUST00000300828.1 ENSMUSG00000130623 (from geneSymbol) uc334nae.1 uc334nae.1 
ENSMUST00000300829.1 ENSMUSG00000130624 ENSMUST00000300829.1 ENSMUSG00000130624 (from geneSymbol) uc334naf.1 uc334naf.1 
ENSMUST00000300833.1 ENSMUSG00000130625 ENSMUST00000300833.1 ENSMUSG00000130625 (from geneSymbol) uc334naj.1 uc334naj.1 
ENSMUST00000300837.1 ENSMUSG00000130626 ENSMUST00000300837.1 ENSMUSG00000130626 (from geneSymbol) uc334nan.1 uc334nan.1 
ENSMUST00000300838.1 ENSMUSG00000130627 ENSMUST00000300838.1 ENSMUSG00000130627 (from geneSymbol) uc334nao.1 uc334nao.1 
ENSMUST00000300841.1 ENSMUSG00000130628 ENSMUST00000300841.1 ENSMUSG00000130628 (from geneSymbol) uc334nar.1 uc334nar.1 
ENSMUST00000300843.1 Gm45064 ENSMUST00000300843.1 Gm45064 (from geneSymbol) uc334nat.1 uc334nat.1 
ENSMUST00000300844.1 ENSMUSG00000130629 ENSMUST00000300844.1 ENSMUSG00000130629 (from geneSymbol) uc334nau.1 uc334nau.1 
ENSMUST00000300847.1 ENSMUSG00000130630 ENSMUST00000300847.1 ENSMUSG00000130630 (from geneSymbol) uc334nax.1 uc334nax.1 
ENSMUST00000300849.1 ENSMUSG00000130631 ENSMUST00000300849.1 ENSMUSG00000130631 (from geneSymbol) uc334naz.1 uc334naz.1 
ENSMUST00000300858.1 ENSMUSG00000130632 ENSMUST00000300858.1 ENSMUSG00000130632 (from geneSymbol) AK016511 uc334nbi.1 uc334nbi.1 
ENSMUST00000300892.1 ENSMUSG00000130633 ENSMUST00000300892.1 ENSMUSG00000130633 (from geneSymbol) uc334ncq.1 uc334ncq.1 
ENSMUST00000300893.1 ENSMUSG00000130634 ENSMUST00000300893.1 ENSMUSG00000130634 (from geneSymbol) uc334ncr.1 uc334ncr.1 
ENSMUST00000300898.1 ENSMUSG00000130636 ENSMUST00000300898.1 ENSMUSG00000130636 (from geneSymbol) uc334ncv.1 uc334ncv.1 
ENSMUST00000300899.1 ENSMUSG00000130637 ENSMUST00000300899.1 ENSMUSG00000130637 (from geneSymbol) uc334ncw.1 uc334ncw.1 
ENSMUST00000300900.1 ENSMUSG00000130638 ENSMUST00000300900.1 ENSMUSG00000130638 (from geneSymbol) uc334ncx.1 uc334ncx.1 
ENSMUST00000300901.1 ENSMUSG00000130639 ENSMUST00000300901.1 ENSMUSG00000130639 (from geneSymbol) uc334ncy.1 uc334ncy.1 
ENSMUST00000300904.1 ENSMUSG00000130640 ENSMUST00000300904.1 ENSMUSG00000130640 (from geneSymbol) uc334ndb.1 uc334ndb.1 
ENSMUST00000300918.1 ENSMUSG00000130641 ENSMUST00000300918.1 ENSMUSG00000130641 (from geneSymbol) uc334ndp.1 uc334ndp.1 
ENSMUST00000300919.1 ENSMUSG00000130642 ENSMUST00000300919.1 ENSMUSG00000130642 (from geneSymbol) uc334ndq.1 uc334ndq.1 
ENSMUST00000300927.1 ENSMUSG00000130643 ENSMUST00000300927.1 ENSMUSG00000130643 (from geneSymbol) uc334ndy.1 uc334ndy.1 
ENSMUST00000300930.1 ENSMUSG00000130644 ENSMUST00000300930.1 ENSMUSG00000130644 (from geneSymbol) uc334neb.1 uc334neb.1 
ENSMUST00000300932.1 ENSMUSG00000130645 ENSMUST00000300932.1 ENSMUSG00000130645 (from geneSymbol) uc334ned.1 uc334ned.1 
ENSMUST00000300933.1 ENSMUSG00000130646 ENSMUST00000300933.1 ENSMUSG00000130646 (from geneSymbol) uc334nee.1 uc334nee.1 
ENSMUST00000300935.1 ENSMUSG00000130647 ENSMUST00000300935.1 ENSMUSG00000130647 (from geneSymbol) uc334neg.1 uc334neg.1 
ENSMUST00000300936.1 ENSMUSG00000130648 ENSMUST00000300936.1 ENSMUSG00000130648 (from geneSymbol) uc334neh.1 uc334neh.1 
ENSMUST00000300938.1 ENSMUSG00000130649 ENSMUST00000300938.1 ENSMUSG00000130649 (from geneSymbol) uc334nej.1 uc334nej.1 
ENSMUST00000300940.1 4930558J18Rik ENSMUST00000300940.1 4930558J18Rik (from geneSymbol) AK016177 uc334nel.1 uc334nel.1 
ENSMUST00000300953.1 ENSMUSG00000130650 ENSMUST00000300953.1 ENSMUSG00000130650 (from geneSymbol) uc334ney.1 uc334ney.1 
ENSMUST00000300954.1 ENSMUSG00000130651 ENSMUST00000300954.1 ENSMUSG00000130651 (from geneSymbol) uc334nez.1 uc334nez.1 
ENSMUST00000300958.1 ENSMUSG00000130652 ENSMUST00000300958.1 ENSMUSG00000130652 (from geneSymbol) uc334nfd.1 uc334nfd.1 
ENSMUST00000300960.1 ENSMUSG00000130653 ENSMUST00000300960.1 ENSMUSG00000130653 (from geneSymbol) uc334nff.1 uc334nff.1 
ENSMUST00000300961.1 ENSMUSG00000130654 ENSMUST00000300961.1 ENSMUSG00000130654 (from geneSymbol) uc334nfg.1 uc334nfg.1 
ENSMUST00000300962.1 ENSMUSG00000130655 ENSMUST00000300962.1 ENSMUSG00000130655 (from geneSymbol) uc334nfh.1 uc334nfh.1 
ENSMUST00000300963.1 ENSMUSG00000130656 ENSMUST00000300963.1 ENSMUSG00000130656 (from geneSymbol) AK133285 uc334nfi.1 uc334nfi.1 
ENSMUST00000300968.1 ENSMUSG00000130658 ENSMUST00000300968.1 ENSMUSG00000130658 (from geneSymbol) uc334nfl.1 uc334nfl.1 
ENSMUST00000300969.1 ENSMUSG00000130659 ENSMUST00000300969.1 ENSMUSG00000130659 (from geneSymbol) uc334nfm.1 uc334nfm.1 
ENSMUST00000300970.1 ENSMUSG00000130660 ENSMUST00000300970.1 ENSMUSG00000130660 (from geneSymbol) uc334nfn.1 uc334nfn.1 
ENSMUST00000300971.1 ENSMUSG00000130661 ENSMUST00000300971.1 ENSMUSG00000130661 (from geneSymbol) uc334nfo.1 uc334nfo.1 
ENSMUST00000300972.1 ENSMUSG00000130662 ENSMUST00000300972.1 ENSMUSG00000130662 (from geneSymbol) uc334nfp.1 uc334nfp.1 
ENSMUST00000300973.1 ENSMUSG00000130663 ENSMUST00000300973.1 ENSMUSG00000130663 (from geneSymbol) uc334nfq.1 uc334nfq.1 
ENSMUST00000300975.1 ENSMUSG00000130664 ENSMUST00000300975.1 ENSMUSG00000130664 (from geneSymbol) uc334nfs.1 uc334nfs.1 
ENSMUST00000300976.1 ENSMUSG00000130665 ENSMUST00000300976.1 ENSMUSG00000130665 (from geneSymbol) uc334nft.1 uc334nft.1 
ENSMUST00000300977.1 ENSMUSG00000130666 ENSMUST00000300977.1 ENSMUSG00000130666 (from geneSymbol) uc334nfu.1 uc334nfu.1 
ENSMUST00000300978.1 ENSMUSG00000130667 ENSMUST00000300978.1 ENSMUSG00000130667 (from geneSymbol) uc334nfv.1 uc334nfv.1 
ENSMUST00000300983.1 ENSMUSG00000130668 ENSMUST00000300983.1 ENSMUSG00000130668 (from geneSymbol) uc334nga.1 uc334nga.1 
ENSMUST00000300985.1 ENSMUSG00000130669 ENSMUST00000300985.1 ENSMUSG00000130669 (from geneSymbol) uc334ngc.1 uc334ngc.1 
ENSMUST00000300986.1 ENSMUSG00000130670 ENSMUST00000300986.1 ENSMUSG00000130670 (from geneSymbol) uc334ngd.1 uc334ngd.1 
ENSMUST00000300987.1 ENSMUSG00000130671 ENSMUST00000300987.1 ENSMUSG00000130671 (from geneSymbol) KY468254 uc334nge.1 uc334nge.1 
ENSMUST00000300988.1 ENSMUSG00000130672 ENSMUST00000300988.1 ENSMUSG00000130672 (from geneSymbol) uc334ngf.1 uc334ngf.1 
ENSMUST00000300989.1 ENSMUSG00000130673 ENSMUST00000300989.1 ENSMUSG00000130673 (from geneSymbol) uc334ngg.1 uc334ngg.1 
ENSMUST00000300990.1 ENSMUSG00000130674 ENSMUST00000300990.1 ENSMUSG00000130674 (from geneSymbol) LF198593 uc334ngh.1 uc334ngh.1 
ENSMUST00000300991.1 ENSMUSG00000130675 ENSMUST00000300991.1 ENSMUSG00000130675 (from geneSymbol) uc334ngi.1 uc334ngi.1 
ENSMUST00000301014.1 ENSMUSG00000130676 ENSMUST00000301014.1 ENSMUSG00000130676 (from geneSymbol) uc334nhf.1 uc334nhf.1 
ENSMUST00000301015.1 ENSMUSG00000130677 ENSMUST00000301015.1 ENSMUSG00000130677 (from geneSymbol) uc334nhg.1 uc334nhg.1 
ENSMUST00000301020.1 Gm26536 ENSMUST00000301020.1 predicted gene, 26536 (from RefSeq NR_168886.1) NR_168886 uc334nhl.1 uc334nhl.1 
ENSMUST00000301022.1 ENSMUSG00000130679 ENSMUST00000301022.1 ENSMUSG00000130679 (from geneSymbol) uc334nhn.1 uc334nhn.1 
ENSMUST00000301023.1 ENSMUSG00000130680 ENSMUST00000301023.1 ENSMUSG00000130680 (from geneSymbol) uc334nho.1 uc334nho.1 
ENSMUST00000301024.1 ENSMUSG00000130681 ENSMUST00000301024.1 ENSMUSG00000130681 (from geneSymbol) uc334nhp.1 uc334nhp.1 
ENSMUST00000301026.1 ENSMUSG00000130682 ENSMUST00000301026.1 ENSMUSG00000130682 (from geneSymbol) uc334nhr.1 uc334nhr.1 
ENSMUST00000301027.1 ENSMUSG00000130683 ENSMUST00000301027.1 ENSMUSG00000130683 (from geneSymbol) uc334nhs.1 uc334nhs.1 
ENSMUST00000301033.1 ENSMUSG00000130684 ENSMUST00000301033.1 ENSMUSG00000130684 (from geneSymbol) uc334nhy.1 uc334nhy.1 
ENSMUST00000301034.1 ENSMUSG00000130685 ENSMUST00000301034.1 ENSMUSG00000130685 (from geneSymbol) uc334nhz.1 uc334nhz.1 
ENSMUST00000301035.1 ENSMUSG00000130686 ENSMUST00000301035.1 ENSMUSG00000130686 (from geneSymbol) uc334nia.1 uc334nia.1 
ENSMUST00000301037.1 ENSMUSG00000130687 ENSMUST00000301037.1 ENSMUSG00000130687 (from geneSymbol) uc334nic.1 uc334nic.1 
ENSMUST00000301038.1 ENSMUSG00000130688 ENSMUST00000301038.1 ENSMUSG00000130688 (from geneSymbol) uc334nid.1 uc334nid.1 
ENSMUST00000301076.1 ENSMUSG00000130689 ENSMUST00000301076.1 ENSMUSG00000130689 (from geneSymbol) uc334njp.1 uc334njp.1 
ENSMUST00000301089.1 ENSMUSG00000130690 ENSMUST00000301089.1 ENSMUSG00000130690 (from geneSymbol) uc334nkc.1 uc334nkc.1 
ENSMUST00000301128.1 ENSMUSG00000130691 ENSMUST00000301128.1 ENSMUSG00000130691 (from geneSymbol) uc334nlp.1 uc334nlp.1 
ENSMUST00000301131.1 ENSMUSG00000130692 ENSMUST00000301131.1 ENSMUSG00000130692 (from geneSymbol) uc334nls.1 uc334nls.1 
ENSMUST00000301135.1 ENSMUSG00000130693 ENSMUST00000301135.1 ENSMUSG00000130693 (from geneSymbol) uc334nlw.1 uc334nlw.1 
ENSMUST00000301163.1 1500032F14Rik ENSMUST00000301163.1 1500032F14Rik (from geneSymbol) uc334nmy.1 uc334nmy.1 
ENSMUST00000301167.1 ENSMUSG00000130694 ENSMUST00000301167.1 ENSMUSG00000130694 (from geneSymbol) uc334nnc.1 uc334nnc.1 
ENSMUST00000301170.1 ENSMUSG00000130695 ENSMUST00000301170.1 ENSMUSG00000130695 (from geneSymbol) MF399063 uc334nnf.1 uc334nnf.1 
ENSMUST00000301171.1 ENSMUSG00000130696 ENSMUST00000301171.1 ENSMUSG00000130696 (from geneSymbol) uc334nng.1 uc334nng.1 
ENSMUST00000301172.1 ENSMUSG00000130697 ENSMUST00000301172.1 ENSMUSG00000130697 (from geneSymbol) uc334nnh.1 uc334nnh.1 
ENSMUST00000301182.1 Gm15401 ENSMUST00000301182.1 Gm15401 (from geneSymbol) AK131839 uc334nnr.1 uc334nnr.1 
ENSMUST00000301185.1 ENSMUSG00000130698 ENSMUST00000301185.1 ENSMUSG00000130698 (from geneSymbol) uc334nnu.1 uc334nnu.1 
ENSMUST00000301191.1 ENSMUSG00000130699 ENSMUST00000301191.1 ENSMUSG00000130699 (from geneSymbol) uc334noa.1 uc334noa.1 
ENSMUST00000301193.1 ENSMUSG00000130701 ENSMUST00000301193.1 ENSMUSG00000130701 (from geneSymbol) uc334nob.1 uc334nob.1 
ENSMUST00000301196.1 BC002059 ENSMUST00000301196.1 BC002059 (from geneSymbol) uc334noe.1 uc334noe.1 
ENSMUST00000301199.1 ENSMUSG00000130702 ENSMUST00000301199.1 ENSMUSG00000130702 (from geneSymbol) uc334noh.1 uc334noh.1 
ENSMUST00000301200.1 ENSMUSG00000130703 ENSMUST00000301200.1 ENSMUSG00000130703 (from geneSymbol) uc334noi.1 uc334noi.1 
ENSMUST00000301203.1 ENSMUSG00000130704 ENSMUST00000301203.1 ENSMUSG00000130704 (from geneSymbol) uc334nol.1 uc334nol.1 
ENSMUST00000301207.1 ENSMUSG00000130705 ENSMUST00000301207.1 ENSMUSG00000130705 (from geneSymbol) uc334nop.1 uc334nop.1 
ENSMUST00000301208.1 ENSMUSG00000130706 ENSMUST00000301208.1 ENSMUSG00000130706 (from geneSymbol) uc334noq.1 uc334noq.1 
ENSMUST00000301209.1 ENSMUSG00000130707 ENSMUST00000301209.1 ENSMUSG00000130707 (from geneSymbol) uc334nor.1 uc334nor.1 
ENSMUST00000301214.1 Gm20389 ENSMUST00000301214.1 Gm20389 (from geneSymbol) AK005945 uc334now.1 uc334now.1 
ENSMUST00000301230.1 ENSMUSG00000130708 ENSMUST00000301230.1 ENSMUSG00000130708 (from geneSymbol) uc334npm.1 uc334npm.1 
ENSMUST00000301231.1 ENSMUSG00000130709 ENSMUST00000301231.1 ENSMUSG00000130709 (from geneSymbol) uc334npn.1 uc334npn.1 
ENSMUST00000301232.1 Gm33497 ENSMUST00000301232.1 Gm33497 (from geneSymbol) uc334npo.1 uc334npo.1 
ENSMUST00000301235.1 ENSMUSG00000130710 ENSMUST00000301235.1 ENSMUSG00000130710 (from geneSymbol) uc334npr.1 uc334npr.1 
ENSMUST00000301239.1 ENSMUSG00000130711 ENSMUST00000301239.1 ENSMUSG00000130711 (from geneSymbol) uc334npv.1 uc334npv.1 
ENSMUST00000301241.1 ENSMUSG00000130712 ENSMUST00000301241.1 ENSMUSG00000130712 (from geneSymbol) uc334npx.1 uc334npx.1 
ENSMUST00000301242.1 ENSMUSG00000130713 ENSMUST00000301242.1 ENSMUSG00000130713 (from geneSymbol) uc334npy.1 uc334npy.1 
ENSMUST00000301251.1 Gm28175 ENSMUST00000301251.1 Gm28175 (from geneSymbol) uc334nqh.1 uc334nqh.1 
ENSMUST00000301286.1 ENSMUSG00000130714 ENSMUST00000301286.1 ENSMUSG00000130714 (from geneSymbol) uc334nrp.1 uc334nrp.1 
ENSMUST00000301300.1 Gm15978 ENSMUST00000301300.1 Gm15978 (from geneSymbol) uc334nsd.1 uc334nsd.1 
ENSMUST00000301311.1 ENSMUSG00000130715 ENSMUST00000301311.1 ENSMUSG00000130715 (from geneSymbol) uc334nso.1 uc334nso.1 
ENSMUST00000301312.1 ENSMUSG00000130716 ENSMUST00000301312.1 ENSMUSG00000130716 (from geneSymbol) uc334nsp.1 uc334nsp.1 
ENSMUST00000301331.1 ENSMUSG00000130717 ENSMUST00000301331.1 ENSMUSG00000130717 (from geneSymbol) uc334nti.1 uc334nti.1 
ENSMUST00000301333.1 ENSMUSG00000130718 ENSMUST00000301333.1 ENSMUSG00000130718 (from geneSymbol) uc334ntk.1 uc334ntk.1 
ENSMUST00000301334.1 ENSMUSG00000130719 ENSMUST00000301334.1 ENSMUSG00000130719 (from geneSymbol) uc334ntl.1 uc334ntl.1 
ENSMUST00000301335.1 ENSMUSG00000130720 ENSMUST00000301335.1 ENSMUSG00000130720 (from geneSymbol) uc334ntm.1 uc334ntm.1 
ENSMUST00000301339.1 ENSMUSG00000130721 ENSMUST00000301339.1 ENSMUSG00000130721 (from geneSymbol) uc334ntq.1 uc334ntq.1 
ENSMUST00000301340.1 Gm45798 ENSMUST00000301340.1 Gm45798 (from geneSymbol) uc334ntr.1 uc334ntr.1 
ENSMUST00000301346.1 Dubr ENSMUST00000301346.1 Dubr (from geneSymbol) AK052569 uc334ntx.1 uc334ntx.1 
ENSMUST00000301358.1 ENSMUSG00000130722 ENSMUST00000301358.1 ENSMUSG00000130722 (from geneSymbol) uc334nuj.1 uc334nuj.1 
ENSMUST00000301359.1 ENSMUSG00000130723 ENSMUST00000301359.1 ENSMUSG00000130723 (from geneSymbol) uc334nuk.1 uc334nuk.1 
ENSMUST00000301360.1 ENSMUSG00000130724 ENSMUST00000301360.1 ENSMUSG00000130724 (from geneSymbol) uc334nul.1 uc334nul.1 
ENSMUST00000301367.1 ENSMUSG00000130725 ENSMUST00000301367.1 ENSMUSG00000130725 (from geneSymbol) uc334nus.1 uc334nus.1 
ENSMUST00000301370.1 ENSMUSG00000130726 ENSMUST00000301370.1 ENSMUSG00000130726 (from geneSymbol) uc334nuv.1 uc334nuv.1 
ENSMUST00000301374.1 Gm57398 ENSMUST00000301374.1 Gm57398 (from geneSymbol) uc334nuz.1 uc334nuz.1 
ENSMUST00000301396.1 ENSMUSG00000130727 ENSMUST00000301396.1 ENSMUSG00000130727 (from geneSymbol) uc334nvv.1 uc334nvv.1 
ENSMUST00000301407.1 ENSMUSG00000130728 ENSMUST00000301407.1 ENSMUSG00000130728 (from geneSymbol) uc334nwg.1 uc334nwg.1 
ENSMUST00000301409.1 Gm11707 ENSMUST00000301409.1 Gm11707 (from geneSymbol) uc334nwi.1 uc334nwi.1 
ENSMUST00000301416.1 ENSMUSG00000130729 ENSMUST00000301416.1 ENSMUSG00000130729 (from geneSymbol) uc334nwp.1 uc334nwp.1 
ENSMUST00000301421.1 ENSMUSG00000130730 ENSMUST00000301421.1 ENSMUSG00000130730 (from geneSymbol) uc334nwu.1 uc334nwu.1 
ENSMUST00000301426.1 ENSMUSG00000130731 ENSMUST00000301426.1 ENSMUSG00000130731 (from geneSymbol) uc334nwz.1 uc334nwz.1 
ENSMUST00000301427.1 ENSMUSG00000130732 ENSMUST00000301427.1 ENSMUSG00000130732 (from geneSymbol) uc334nxa.1 uc334nxa.1 
ENSMUST00000301428.1 ENSMUSG00000130733 ENSMUST00000301428.1 ENSMUSG00000130733 (from geneSymbol) AK042213 uc334nxb.1 uc334nxb.1 
ENSMUST00000301429.1 ENSMUSG00000130734 ENSMUST00000301429.1 ENSMUSG00000130734 (from geneSymbol) uc334nxc.1 uc334nxc.1 
ENSMUST00000301430.1 ENSMUSG00000130735 ENSMUST00000301430.1 ENSMUSG00000130735 (from geneSymbol) AY512909 uc334nxd.1 uc334nxd.1 
ENSMUST00000301431.1 ENSMUSG00000130736 ENSMUST00000301431.1 ENSMUSG00000130736 (from geneSymbol) uc334nxe.1 uc334nxe.1 
ENSMUST00000301434.1 Gm30853 ENSMUST00000301434.1 Gm30853 (from geneSymbol) AK076946 uc334nxh.1 uc334nxh.1 
ENSMUST00000301453.1 ENSMUSG00000130737 ENSMUST00000301453.1 ENSMUSG00000130737 (from geneSymbol) uc334nya.1 uc334nya.1 
ENSMUST00000301456.1 Gm48834 ENSMUST00000301456.1 Gm48834 (from geneSymbol) uc334nyd.1 uc334nyd.1 
ENSMUST00000301466.1 ENSMUSG00000130738 ENSMUST00000301466.1 ENSMUSG00000130738 (from geneSymbol) uc334nyn.1 uc334nyn.1 
ENSMUST00000301467.1 ENSMUSG00000130739 ENSMUST00000301467.1 ENSMUSG00000130739 (from geneSymbol) uc334nyo.1 uc334nyo.1 
ENSMUST00000301468.1 4930458K08Rik ENSMUST00000301468.1 4930458K08Rik (from geneSymbol) AK015485 uc334nyp.1 uc334nyp.1 
ENSMUST00000301476.1 ENSMUSG00000130740 ENSMUST00000301476.1 ENSMUSG00000130740 (from geneSymbol) uc334nyx.1 uc334nyx.1 
ENSMUST00000301477.1 ENSMUSG00000130741 ENSMUST00000301477.1 ENSMUSG00000130741 (from geneSymbol) uc334nyy.1 uc334nyy.1 
ENSMUST00000301479.1 ENSMUSG00000130742 ENSMUST00000301479.1 ENSMUSG00000130742 (from geneSymbol) uc334nza.1 uc334nza.1 
ENSMUST00000301482.1 ENSMUSG00000130743 ENSMUST00000301482.1 ENSMUSG00000130743 (from geneSymbol) uc334nzd.1 uc334nzd.1 
ENSMUST00000301487.1 ENSMUSG00000130744 ENSMUST00000301487.1 ENSMUSG00000130744 (from geneSymbol) uc334nzi.1 uc334nzi.1 
ENSMUST00000301533.1 ENSMUSG00000130745 ENSMUST00000301533.1 ENSMUSG00000130745 (from geneSymbol) uc334oba.1 uc334oba.1 
ENSMUST00000301534.1 ENSMUSG00000130746 ENSMUST00000301534.1 ENSMUSG00000130746 (from geneSymbol) uc334obb.1 uc334obb.1 
ENSMUST00000301539.1 ENSMUSG00000130747 ENSMUST00000301539.1 ENSMUSG00000130747 (from geneSymbol) uc334obg.1 uc334obg.1 
ENSMUST00000301540.1 Gm11789 ENSMUST00000301540.1 Gm11789 (from geneSymbol) KY467626 uc334obh.1 uc334obh.1 
ENSMUST00000301572.1 Gm45349 ENSMUST00000301572.1 Gm45349 (from geneSymbol) uc334ocn.1 uc334ocn.1 
ENSMUST00000301604.1 ENSMUSG00000130748 ENSMUST00000301604.1 ENSMUSG00000130748 (from geneSymbol) uc334odt.1 uc334odt.1 
ENSMUST00000301605.1 ENSMUSG00000130749 ENSMUST00000301605.1 ENSMUSG00000130749 (from geneSymbol) uc334odu.1 uc334odu.1 
ENSMUST00000301617.1 ENSMUSG00000130750 ENSMUST00000301617.1 ENSMUSG00000130750 (from geneSymbol) uc334oeg.1 uc334oeg.1 
ENSMUST00000301633.1 2310039L15Rik ENSMUST00000301633.1 2310039L15Rik (from geneSymbol) AK009705 uc334oew.1 uc334oew.1 
ENSMUST00000301646.1 ENSMUSG00000130751 ENSMUST00000301646.1 ENSMUSG00000130751 (from geneSymbol) uc334ofj.1 uc334ofj.1 
ENSMUST00000301647.1 ENSMUSG00000130752 ENSMUST00000301647.1 ENSMUSG00000130752 (from geneSymbol) uc334ofk.1 uc334ofk.1 
ENSMUST00000301648.1 ENSMUSG00000130753 ENSMUST00000301648.1 ENSMUSG00000130753 (from geneSymbol) uc334ofl.1 uc334ofl.1 
ENSMUST00000301649.1 ENSMUSG00000130754 ENSMUST00000301649.1 ENSMUSG00000130754 (from geneSymbol) uc334ofm.1 uc334ofm.1 
ENSMUST00000301650.1 ENSMUSG00000130755 ENSMUST00000301650.1 ENSMUSG00000130755 (from geneSymbol) uc334ofn.1 uc334ofn.1 
ENSMUST00000301651.1 ENSMUSG00000130756 ENSMUST00000301651.1 ENSMUSG00000130756 (from geneSymbol) uc334ofo.1 uc334ofo.1 
ENSMUST00000301652.1 ENSMUSG00000130757 ENSMUST00000301652.1 ENSMUSG00000130757 (from geneSymbol) uc334ofp.1 uc334ofp.1 
ENSMUST00000301654.1 ENSMUSG00000130758 ENSMUST00000301654.1 ENSMUSG00000130758 (from geneSymbol) uc334ofr.1 uc334ofr.1 
ENSMUST00000301657.1 ENSMUSG00000130759 ENSMUST00000301657.1 ENSMUSG00000130759 (from geneSymbol) uc334ofu.1 uc334ofu.1 
ENSMUST00000301659.1 ENSMUSG00000130760 ENSMUST00000301659.1 ENSMUSG00000130760 (from geneSymbol) uc334ofw.1 uc334ofw.1 
ENSMUST00000301661.1 ENSMUSG00000130761 ENSMUST00000301661.1 ENSMUSG00000130761 (from geneSymbol) uc334ofy.1 uc334ofy.1 
ENSMUST00000301662.1 ENSMUSG00000130762 ENSMUST00000301662.1 ENSMUSG00000130762 (from geneSymbol) uc334ofz.1 uc334ofz.1 
ENSMUST00000301669.1 ENSMUSG00000130763 ENSMUST00000301669.1 ENSMUSG00000130763 (from geneSymbol) uc334ogg.1 uc334ogg.1 
ENSMUST00000301674.1 ENSMUSG00000130764 ENSMUST00000301674.1 ENSMUSG00000130764 (from geneSymbol) uc334ogl.1 uc334ogl.1 
ENSMUST00000301676.1 ENSMUSG00000130765 ENSMUST00000301676.1 ENSMUSG00000130765 (from geneSymbol) uc334ogn.1 uc334ogn.1 
ENSMUST00000301677.1 ENSMUSG00000130766 ENSMUST00000301677.1 ENSMUSG00000130766 (from geneSymbol) uc334ogo.1 uc334ogo.1 
ENSMUST00000301678.1 ENSMUSG00000130767 ENSMUST00000301678.1 ENSMUSG00000130767 (from geneSymbol) uc334ogp.1 uc334ogp.1 
ENSMUST00000301683.1 Gm49123 ENSMUST00000301683.1 Gm49123 (from geneSymbol) uc334ogu.1 uc334ogu.1 
ENSMUST00000301705.1 ENSMUSG00000130768 ENSMUST00000301705.1 ENSMUSG00000130768 (from geneSymbol) uc334ohq.1 uc334ohq.1 
ENSMUST00000301707.1 ENSMUSG00000130769 ENSMUST00000301707.1 ENSMUSG00000130769 (from geneSymbol) uc334ohs.1 uc334ohs.1 
ENSMUST00000301708.1 ENSMUSG00000130770 ENSMUST00000301708.1 ENSMUSG00000130770 (from geneSymbol) uc334oht.1 uc334oht.1 
ENSMUST00000301710.1 ENSMUSG00000130771 ENSMUST00000301710.1 ENSMUSG00000130771 (from geneSymbol) uc334ohv.1 uc334ohv.1 
ENSMUST00000301711.1 ENSMUSG00000130772 ENSMUST00000301711.1 ENSMUSG00000130772 (from geneSymbol) uc334ohw.1 uc334ohw.1 
ENSMUST00000301720.1 4930451E10Rik ENSMUST00000301720.1 4930451E10Rik (from geneSymbol) AK019623 uc334oif.1 uc334oif.1 
ENSMUST00000301727.1 ENSMUSG00000130773 ENSMUST00000301727.1 ENSMUSG00000130773 (from geneSymbol) uc334oim.1 uc334oim.1 
ENSMUST00000301732.1 ENSMUSG00000130774 ENSMUST00000301732.1 ENSMUSG00000130774 (from geneSymbol) uc334oir.1 uc334oir.1 
ENSMUST00000301749.1 Gm13391 ENSMUST00000301749.1 Gm13391 (from geneSymbol) AK131873 uc334ojh.1 uc334ojh.1 
ENSMUST00000301763.1 ENSMUSG00000130775 ENSMUST00000301763.1 ENSMUSG00000130775 (from geneSymbol) uc334ojv.1 uc334ojv.1 
ENSMUST00000301769.1 ENSMUSG00000130776 ENSMUST00000301769.1 ENSMUSG00000130776 (from geneSymbol) uc334okb.1 uc334okb.1 
ENSMUST00000301770.1 ENSMUSG00000130777 ENSMUST00000301770.1 ENSMUSG00000130777 (from geneSymbol) uc334okc.1 uc334okc.1 
ENSMUST00000301772.1 Gm19277 ENSMUST00000301772.1 Gm19277 (from geneSymbol) AK085771 uc334oke.1 uc334oke.1 
ENSMUST00000301779.1 ENSMUSG00000130778 ENSMUST00000301779.1 ENSMUSG00000130778 (from geneSymbol) uc334okl.1 uc334okl.1 
ENSMUST00000301780.1 ENSMUSG00000130779 ENSMUST00000301780.1 ENSMUSG00000130779 (from geneSymbol) uc334okm.1 uc334okm.1 
ENSMUST00000301782.1 ENSMUSG00000130780 ENSMUST00000301782.1 ENSMUSG00000130780 (from geneSymbol) uc334oko.1 uc334oko.1 
ENSMUST00000301783.1 C030013G03Rik ENSMUST00000301783.1 RIKEN cDNA C030013G03 gene, transcript variant 1 (from RefSeq NR_077216.1) NR_077216 uc334okp.1 uc334okp.1 
ENSMUST00000301784.1 4931403G20Rik ENSMUST00000301784.1 RIKEN cDNA 4931403G20 gene, transcript variant 2 (from RefSeq NR_038173.1) NR_038173 uc334okq.1 uc334okq.1 
ENSMUST00000301787.1 ENSMUSG00000130782 ENSMUST00000301787.1 ENSMUSG00000130782 (from geneSymbol) uc334okt.1 uc334okt.1 
ENSMUST00000301804.1 1700047M11Rik ENSMUST00000301804.1 1700047M11Rik (from geneSymbol) AK047804 uc334olk.1 uc334olk.1 
ENSMUST00000301859.1 ENSMUSG00000130783 ENSMUST00000301859.1 ENSMUSG00000130783 (from geneSymbol) uc334onn.1 uc334onn.1 
ENSMUST00000301861.1 ENSMUSG00000130784 ENSMUST00000301861.1 ENSMUSG00000130784 (from geneSymbol) uc334onp.1 uc334onp.1 
ENSMUST00000301865.1 ENSMUSG00000130785 ENSMUST00000301865.1 ENSMUSG00000130785 (from geneSymbol) uc334ont.1 uc334ont.1 
ENSMUST00000301871.1 4930402F11Rik ENSMUST00000301871.1 4930402F11Rik (from geneSymbol) AK015048 uc334onz.1 uc334onz.1 
ENSMUST00000301906.1 ENSMUSG00000130786 ENSMUST00000301906.1 ENSMUSG00000130786 (from geneSymbol) uc334opi.1 uc334opi.1 
ENSMUST00000301917.1 4930555K19Rik ENSMUST00000301917.1 4930555K19Rik (from geneSymbol) uc334opt.1 uc334opt.1 
ENSMUST00000301924.1 ENSMUSG00000130789 ENSMUST00000301924.1 ENSMUSG00000130789 (from geneSymbol) uc334opy.1 uc334opy.1 
ENSMUST00000301934.1 ENSMUSG00000130790 ENSMUST00000301934.1 ENSMUSG00000130790 (from geneSymbol) uc334oqi.1 uc334oqi.1 
ENSMUST00000301938.1 ENSMUSG00000130791 ENSMUST00000301938.1 ENSMUSG00000130791 (from geneSymbol) uc334oqm.1 uc334oqm.1 
ENSMUST00000301943.1 ENSMUSG00000130792 ENSMUST00000301943.1 ENSMUSG00000130792 (from geneSymbol) uc334oqr.1 uc334oqr.1 
ENSMUST00000301947.1 Gm12866 ENSMUST00000301947.1 Gm12866 (from geneSymbol) AK084134 uc334oqv.1 uc334oqv.1 
ENSMUST00000301955.1 ENSMUSG00000130793 ENSMUST00000301955.1 ENSMUSG00000130793 (from geneSymbol) uc334ord.1 uc334ord.1 
ENSMUST00000301958.1 ENSMUSG00000130794 ENSMUST00000301958.1 ENSMUSG00000130794 (from geneSymbol) BC099537 uc334org.1 uc334org.1 
ENSMUST00000301961.1 ENSMUSG00000130795 ENSMUST00000301961.1 ENSMUSG00000130795 (from geneSymbol) uc334orj.1 uc334orj.1 
ENSMUST00000301964.1 ENSMUSG00000130797 ENSMUST00000301964.1 ENSMUSG00000130797 (from geneSymbol) uc334orl.1 uc334orl.1 
ENSMUST00000301965.1 ENSMUSG00000130798 ENSMUST00000301965.1 ENSMUSG00000130798 (from geneSymbol) uc334orm.1 uc334orm.1 
ENSMUST00000301966.1 ENSMUSG00000130799 ENSMUST00000301966.1 ENSMUSG00000130799 (from geneSymbol) uc334orn.1 uc334orn.1 
ENSMUST00000301967.1 ENSMUSG00000130800 ENSMUST00000301967.1 ENSMUSG00000130800 (from geneSymbol) uc334oro.1 uc334oro.1 
ENSMUST00000301968.1 ENSMUSG00000130801 ENSMUST00000301968.1 ENSMUSG00000130801 (from geneSymbol) uc334orp.1 uc334orp.1 
ENSMUST00000301983.1 ENSMUSG00000130802 ENSMUST00000301983.1 ENSMUSG00000130802 (from geneSymbol) uc334ose.1 uc334ose.1 
ENSMUST00000301984.1 ENSMUSG00000130803 ENSMUST00000301984.1 ENSMUSG00000130803 (from geneSymbol) LF198233 uc334osf.1 uc334osf.1 
ENSMUST00000301985.1 ENSMUSG00000130804 ENSMUST00000301985.1 ENSMUSG00000130804 (from geneSymbol) uc334osg.1 uc334osg.1 
ENSMUST00000301988.1 ENSMUSG00000130805 ENSMUST00000301988.1 ENSMUSG00000130805 (from geneSymbol) uc334osj.1 uc334osj.1 
ENSMUST00000301992.1 ENSMUSG00000130806 ENSMUST00000301992.1 ENSMUSG00000130806 (from geneSymbol) uc334osn.1 uc334osn.1 
ENSMUST00000301995.1 ENSMUSG00000130807 ENSMUST00000301995.1 ENSMUSG00000130807 (from geneSymbol) uc334osq.1 uc334osq.1 
ENSMUST00000301998.1 ENSMUSG00000130808 ENSMUST00000301998.1 ENSMUSG00000130808 (from geneSymbol) uc334ost.1 uc334ost.1 
ENSMUST00000302000.1 ENSMUSG00000130809 ENSMUST00000302000.1 ENSMUSG00000130809 (from geneSymbol) AK039511 uc334osv.1 uc334osv.1 
ENSMUST00000302003.1 ENSMUSG00000130810 ENSMUST00000302003.1 ENSMUSG00000130810 (from geneSymbol) uc334osy.1 uc334osy.1 
ENSMUST00000302004.1 ENSMUSG00000130811 ENSMUST00000302004.1 ENSMUSG00000130811 (from geneSymbol) uc334osz.1 uc334osz.1 
ENSMUST00000302008.1 ENSMUSG00000130812 ENSMUST00000302008.1 ENSMUSG00000130812 (from geneSymbol) uc334otd.1 uc334otd.1 
ENSMUST00000302011.1 ENSMUSG00000130813 ENSMUST00000302011.1 ENSMUSG00000130813 (from geneSymbol) uc334otf.1 uc334otf.1 
ENSMUST00000302019.1 Gm28068 ENSMUST00000302019.1 Gm28068 (from geneSymbol) uc334otn.1 uc334otn.1 
ENSMUST00000302038.1 Gm30954 ENSMUST00000302038.1 Gm30954 (from geneSymbol) uc334oug.1 uc334oug.1 
ENSMUST00000302095.1 ENSMUSG00000130814 ENSMUST00000302095.1 ENSMUSG00000130814 (from geneSymbol) uc334owl.1 uc334owl.1 
ENSMUST00000302096.1 ENSMUSG00000130815 ENSMUST00000302096.1 ENSMUSG00000130815 (from geneSymbol) uc334owm.1 uc334owm.1 
ENSMUST00000302097.1 ENSMUSG00000130816 ENSMUST00000302097.1 ENSMUSG00000130816 (from geneSymbol) uc334own.1 uc334own.1 
ENSMUST00000302099.1 ENSMUSG00000130817 ENSMUST00000302099.1 ENSMUSG00000130817 (from geneSymbol) uc334owp.1 uc334owp.1 
ENSMUST00000302100.1 4921517D16Rik ENSMUST00000302100.1 4921517D16Rik (from geneSymbol) AK014907 uc334owq.1 uc334owq.1 
ENSMUST00000302108.1 Gm37565 ENSMUST00000302108.1 Gm37565 (from geneSymbol) uc334owy.1 uc334owy.1 
ENSMUST00000302112.1 Gm16347 ENSMUST00000302112.1 Gm16347 (from geneSymbol) uc334oxc.1 uc334oxc.1 
ENSMUST00000302133.1 ENSMUSG00000130818 ENSMUST00000302133.1 ENSMUSG00000130818 (from geneSymbol) uc334oxx.1 uc334oxx.1 
ENSMUST00000302134.1 ENSMUSG00000130819 ENSMUST00000302134.1 ENSMUSG00000130819 (from geneSymbol) uc334oxy.1 uc334oxy.1 
ENSMUST00000302135.1 ENSMUSG00000130820 ENSMUST00000302135.1 ENSMUSG00000130820 (from geneSymbol) uc334oxz.1 uc334oxz.1 
ENSMUST00000302137.1 ENSMUSG00000130821 ENSMUST00000302137.1 ENSMUSG00000130821 (from geneSymbol) uc334oyb.1 uc334oyb.1 
ENSMUST00000302139.1 ENSMUSG00000130822 ENSMUST00000302139.1 ENSMUSG00000130822 (from geneSymbol) uc334oyd.1 uc334oyd.1 
ENSMUST00000302158.1 ENSMUSG00000130823 ENSMUST00000302158.1 ENSMUSG00000130823 (from geneSymbol) uc334oyw.1 uc334oyw.1 
ENSMUST00000302160.1 ENSMUSG00000130824 ENSMUST00000302160.1 ENSMUSG00000130824 (from geneSymbol) uc334oyy.1 uc334oyy.1 
ENSMUST00000302163.1 Gm33570 ENSMUST00000302163.1 Gm33570 (from geneSymbol) uc334ozb.1 uc334ozb.1 
ENSMUST00000302175.1 C730034F03Rik ENSMUST00000302175.1 C730034F03Rik (from geneSymbol) uc334ozn.1 uc334ozn.1 
ENSMUST00000302179.1 ENSMUSG00000130825 ENSMUST00000302179.1 ENSMUSG00000130825 (from geneSymbol) uc334ozr.1 uc334ozr.1 
ENSMUST00000302181.1 ENSMUSG00000130826 ENSMUST00000302181.1 ENSMUSG00000130826 (from geneSymbol) uc334ozt.1 uc334ozt.1 
ENSMUST00000302184.1 ENSMUSG00000130827 ENSMUST00000302184.1 ENSMUSG00000130827 (from geneSymbol) uc334ozw.1 uc334ozw.1 
ENSMUST00000302186.1 ENSMUSG00000130828 ENSMUST00000302186.1 ENSMUSG00000130828 (from geneSymbol) uc334ozy.1 uc334ozy.1 
ENSMUST00000302187.1 ENSMUSG00000130829 ENSMUST00000302187.1 ENSMUSG00000130829 (from geneSymbol) uc334ozz.1 uc334ozz.1 
ENSMUST00000302188.1 ENSMUSG00000130830 ENSMUST00000302188.1 ENSMUSG00000130830 (from geneSymbol) uc334paa.1 uc334paa.1 
ENSMUST00000302191.1 ENSMUSG00000130831 ENSMUST00000302191.1 ENSMUSG00000130831 (from geneSymbol) LF205082 uc334pad.1 uc334pad.1 
ENSMUST00000302197.1 ENSMUSG00000130832 ENSMUST00000302197.1 ENSMUSG00000130832 (from geneSymbol) uc334paj.1 uc334paj.1 
ENSMUST00000302216.1 ENSMUSG00000130833 ENSMUST00000302216.1 ENSMUSG00000130833 (from geneSymbol) AK076790 uc334pbc.1 uc334pbc.1 
ENSMUST00000302218.1 ENSMUSG00000130834 ENSMUST00000302218.1 ENSMUSG00000130834 (from geneSymbol) uc334pbe.1 uc334pbe.1 
ENSMUST00000302227.1 Gm6557 ENSMUST00000302227.1 Gm6557 (from geneSymbol) LF200667 uc334pbm.1 uc334pbm.1 
ENSMUST00000302228.1 ENSMUSG00000130836 ENSMUST00000302228.1 ENSMUSG00000130836 (from geneSymbol) uc334pbn.1 uc334pbn.1 
ENSMUST00000302229.1 ENSMUSG00000130837 ENSMUST00000302229.1 ENSMUSG00000130837 (from geneSymbol) uc334pbo.1 uc334pbo.1 
ENSMUST00000302230.1 ENSMUSG00000130838 ENSMUST00000302230.1 ENSMUSG00000130838 (from geneSymbol) uc334pbp.1 uc334pbp.1 
ENSMUST00000302233.1 ENSMUSG00000130839 ENSMUST00000302233.1 ENSMUSG00000130839 (from geneSymbol) uc334pbs.1 uc334pbs.1 
ENSMUST00000302253.1 ENSMUSG00000130840 ENSMUST00000302253.1 ENSMUSG00000130840 (from geneSymbol) LF199947 uc334pcm.1 uc334pcm.1 
ENSMUST00000302254.1 ENSMUSG00000130841 ENSMUST00000302254.1 ENSMUSG00000130841 (from geneSymbol) uc334pcn.1 uc334pcn.1 
ENSMUST00000302258.1 ENSMUSG00000130842 ENSMUST00000302258.1 ENSMUSG00000130842 (from geneSymbol) uc334pcr.1 uc334pcr.1 
ENSMUST00000302269.1 ENSMUSG00000130843 ENSMUST00000302269.1 ENSMUSG00000130843 (from geneSymbol) uc334pdc.1 uc334pdc.1 
ENSMUST00000302270.1 ENSMUSG00000130844 ENSMUST00000302270.1 ENSMUSG00000130844 (from geneSymbol) uc334pdd.1 uc334pdd.1 
ENSMUST00000302271.1 ENSMUSG00000130845 ENSMUST00000302271.1 ENSMUSG00000130845 (from geneSymbol) LF194368 uc334pde.1 uc334pde.1 
ENSMUST00000302272.1 ENSMUSG00000130846 ENSMUST00000302272.1 ENSMUSG00000130846 (from geneSymbol) uc334pdf.1 uc334pdf.1 
ENSMUST00000302273.1 ENSMUSG00000130847 ENSMUST00000302273.1 ENSMUSG00000130847 (from geneSymbol) uc334pdg.1 uc334pdg.1 
ENSMUST00000302276.1 ENSMUSG00000130848 ENSMUST00000302276.1 ENSMUSG00000130848 (from geneSymbol) uc334pdj.1 uc334pdj.1 
ENSMUST00000302278.1 Gm53692 ENSMUST00000302278.1 Gm53692 (from geneSymbol) AK054074 uc334pdl.1 uc334pdl.1 
ENSMUST00000302284.1 ENSMUSG00000130849 ENSMUST00000302284.1 ENSMUSG00000130849 (from geneSymbol) uc334pdr.1 uc334pdr.1 
ENSMUST00000302285.1 ENSMUSG00000130850 ENSMUST00000302285.1 ENSMUSG00000130850 (from geneSymbol) uc334pds.1 uc334pds.1 
ENSMUST00000302286.1 ENSMUSG00000130851 ENSMUST00000302286.1 ENSMUSG00000130851 (from geneSymbol) uc334pdt.1 uc334pdt.1 
ENSMUST00000302287.1 1700022A21Rik ENSMUST00000302287.1 1700022A21Rik (from geneSymbol) AK006230 uc334pdu.1 uc334pdu.1 
ENSMUST00000302292.1 ENSMUSG00000130852 ENSMUST00000302292.1 ENSMUSG00000130852 (from geneSymbol) uc334pdz.1 uc334pdz.1 
ENSMUST00000302293.1 ENSMUSG00000130853 ENSMUST00000302293.1 ENSMUSG00000130853 (from geneSymbol) uc334pea.1 uc334pea.1 
ENSMUST00000302297.1 Gm17215 ENSMUST00000302297.1 Gm17215 (from geneSymbol) uc334pee.1 uc334pee.1 
ENSMUST00000302305.1 ENSMUSG00000130854 ENSMUST00000302305.1 ENSMUSG00000130854 (from geneSymbol) uc334pem.1 uc334pem.1 
ENSMUST00000302306.1 ENSMUSG00000130855 ENSMUST00000302306.1 ENSMUSG00000130855 (from geneSymbol) LF200216 uc334pen.1 uc334pen.1 
ENSMUST00000302308.1 Gm38825 ENSMUST00000302308.1 Gm38825 (from geneSymbol) uc334peo.1 uc334peo.1 
ENSMUST00000302310.1 Gm36816 ENSMUST00000302310.1 Gm36816 (from geneSymbol) uc334peq.1 uc334peq.1 
ENSMUST00000302317.1 ENSMUSG00000130856 ENSMUST00000302317.1 ENSMUSG00000130856 (from geneSymbol) uc334pex.1 uc334pex.1 
ENSMUST00000302318.1 ENSMUSG00000130857 ENSMUST00000302318.1 ENSMUSG00000130857 (from geneSymbol) uc334pey.1 uc334pey.1 
ENSMUST00000302319.1 ENSMUSG00000130858 ENSMUST00000302319.1 ENSMUSG00000130858 (from geneSymbol) AK019808 uc334pez.1 uc334pez.1 
ENSMUST00000302324.1 Gm57439 ENSMUST00000302324.1 Gm57439 (from geneSymbol) KY467919 uc334pfe.1 uc334pfe.1 
ENSMUST00000302327.1 ENSMUSG00000130859 ENSMUST00000302327.1 ENSMUSG00000130859 (from geneSymbol) uc334pfh.1 uc334pfh.1 
ENSMUST00000302329.1 Gm7967 ENSMUST00000302329.1 Gm7967 (from geneSymbol) AK144617 uc334pfj.1 uc334pfj.1 
ENSMUST00000302358.1 ENSMUSG00000130860 ENSMUST00000302358.1 ENSMUSG00000130860 (from geneSymbol) uc334pgm.1 uc334pgm.1 
ENSMUST00000302359.1 ENSMUSG00000130861 ENSMUST00000302359.1 ENSMUSG00000130861 (from geneSymbol) uc334pgn.1 uc334pgn.1 
ENSMUST00000302379.1 ENSMUSG00000130862 ENSMUST00000302379.1 ENSMUSG00000130862 (from geneSymbol) uc334phh.1 uc334phh.1 
ENSMUST00000302382.1 ENSMUSG00000130863 ENSMUST00000302382.1 ENSMUSG00000130863 (from geneSymbol) uc334phk.1 uc334phk.1 
ENSMUST00000302383.1 ENSMUSG00000130864 ENSMUST00000302383.1 ENSMUSG00000130864 (from geneSymbol) uc334phl.1 uc334phl.1 
ENSMUST00000302384.1 ENSMUSG00000130865 ENSMUST00000302384.1 ENSMUSG00000130865 (from geneSymbol) uc334phm.1 uc334phm.1 
ENSMUST00000302385.1 ENSMUSG00000130866 ENSMUST00000302385.1 ENSMUSG00000130866 (from geneSymbol) uc334phn.1 uc334phn.1 
ENSMUST00000302388.1 Slc36a3os ENSMUST00000302388.1 Slc36a3os (from geneSymbol) AK040665 uc334phq.1 uc334phq.1 
ENSMUST00000302390.1 ENSMUSG00000130867 ENSMUST00000302390.1 ENSMUSG00000130867 (from geneSymbol) uc334phs.1 uc334phs.1 
ENSMUST00000302392.1 ENSMUSG00000130868 ENSMUST00000302392.1 ENSMUSG00000130868 (from geneSymbol) JQ173110 uc334phu.1 uc334phu.1 
ENSMUST00000302396.1 ENSMUSG00000130869 ENSMUST00000302396.1 ENSMUSG00000130869 (from geneSymbol) uc334phy.1 uc334phy.1 
ENSMUST00000302401.1 ENSMUSG00000130870 ENSMUST00000302401.1 ENSMUSG00000130870 (from geneSymbol) uc334pid.1 uc334pid.1 
ENSMUST00000302402.1 Gm43640 ENSMUST00000302402.1 Gm43640 (from geneSymbol) uc334pie.1 uc334pie.1 
ENSMUST00000302412.1 ENSMUSG00000130871 ENSMUST00000302412.1 ENSMUSG00000130871 (from geneSymbol) uc334pio.1 uc334pio.1 
ENSMUST00000302417.1 ENSMUSG00000130872 ENSMUST00000302417.1 ENSMUSG00000130872 (from geneSymbol) uc334pit.1 uc334pit.1 
ENSMUST00000302418.1 ENSMUSG00000130873 ENSMUST00000302418.1 ENSMUSG00000130873 (from geneSymbol) uc334piu.1 uc334piu.1 
ENSMUST00000302420.1 ENSMUSG00000130874 ENSMUST00000302420.1 ENSMUSG00000130874 (from geneSymbol) uc334piw.1 uc334piw.1 
ENSMUST00000302421.1 Gm15952 ENSMUST00000302421.1 Gm15952 (from geneSymbol) uc334pix.1 uc334pix.1 
ENSMUST00000302427.1 ENSMUSG00000130875 ENSMUST00000302427.1 ENSMUSG00000130875 (from geneSymbol) uc334pjd.1 uc334pjd.1 
ENSMUST00000302436.1 ENSMUSG00000130876 ENSMUST00000302436.1 ENSMUSG00000130876 (from geneSymbol) uc334pjm.1 uc334pjm.1 
ENSMUST00000302437.1 ENSMUSG00000130877 ENSMUST00000302437.1 ENSMUSG00000130877 (from geneSymbol) uc334pjn.1 uc334pjn.1 
ENSMUST00000302438.1 ENSMUSG00000130878 ENSMUST00000302438.1 ENSMUSG00000130878 (from geneSymbol) uc334pjo.1 uc334pjo.1 
ENSMUST00000302442.1 Mir9-2hg ENSMUST00000302442.1 Mir9-2hg (from geneSymbol) AK013308 uc334pjs.1 uc334pjs.1 
ENSMUST00000302568.1 Gm35994 ENSMUST00000302568.1 Gm35994 (from geneSymbol) uc334pom.1 uc334pom.1 
ENSMUST00000302574.1 ENSMUSG00000130881 ENSMUST00000302574.1 ENSMUSG00000130881 (from geneSymbol) uc334pos.1 uc334pos.1 
ENSMUST00000302576.1 ENSMUSG00000130882 ENSMUST00000302576.1 ENSMUSG00000130882 (from geneSymbol) uc334pou.1 uc334pou.1 
ENSMUST00000302582.1 ENSMUSG00000130883 ENSMUST00000302582.1 ENSMUSG00000130883 (from geneSymbol) uc334ppa.1 uc334ppa.1 
ENSMUST00000302583.1 ENSMUSG00000130884 ENSMUST00000302583.1 ENSMUSG00000130884 (from geneSymbol) uc334ppb.1 uc334ppb.1 
ENSMUST00000302587.1 ENSMUSG00000130885 ENSMUST00000302587.1 ENSMUSG00000130885 (from geneSymbol) uc334ppf.1 uc334ppf.1 
ENSMUST00000302618.1 ENSMUSG00000130886 ENSMUST00000302618.1 ENSMUSG00000130886 (from geneSymbol) uc334pqk.1 uc334pqk.1 
ENSMUST00000302619.1 ENSMUSG00000130887 ENSMUST00000302619.1 ENSMUSG00000130887 (from geneSymbol) AK006675 uc334pql.1 uc334pql.1 
ENSMUST00000302620.1 ENSMUSG00000130888 ENSMUST00000302620.1 ENSMUSG00000130888 (from geneSymbol) uc334pqm.1 uc334pqm.1 
ENSMUST00000302635.1 ENSMUSG00000130889 ENSMUST00000302635.1 ENSMUSG00000130889 (from geneSymbol) uc334prb.1 uc334prb.1 
ENSMUST00000302641.1 4933432I09Rik ENSMUST00000302641.1 4933432I09Rik (from geneSymbol) AK161480 uc334prh.1 uc334prh.1 
ENSMUST00000302659.1 ENSMUSG00000130890 ENSMUST00000302659.1 ENSMUSG00000130890 (from geneSymbol) uc334prz.1 uc334prz.1 
ENSMUST00000302660.1 ENSMUSG00000130891 ENSMUST00000302660.1 ENSMUSG00000130891 (from geneSymbol) uc334psa.1 uc334psa.1 
ENSMUST00000302661.1 ENSMUSG00000130892 ENSMUST00000302661.1 ENSMUSG00000130892 (from geneSymbol) uc334psb.1 uc334psb.1 
ENSMUST00000302662.1 ENSMUSG00000130893 ENSMUST00000302662.1 ENSMUSG00000130893 (from geneSymbol) uc334psc.1 uc334psc.1 
ENSMUST00000302664.1 ENSMUSG00000130894 ENSMUST00000302664.1 ENSMUSG00000130894 (from geneSymbol) uc334pse.1 uc334pse.1 
ENSMUST00000302666.1 E230016M11Rik ENSMUST00000302666.1 E230016M11Rik (from geneSymbol) AK039826 uc334psg.1 uc334psg.1 
ENSMUST00000302678.1 4933424H11Rik ENSMUST00000302678.1 4933424H11Rik (from geneSymbol) uc334pss.1 uc334pss.1 
ENSMUST00000302681.1 ENSMUSG00000130895 ENSMUST00000302681.1 ENSMUSG00000130895 (from geneSymbol) uc334psv.1 uc334psv.1 
ENSMUST00000302682.1 ENSMUSG00000130896 ENSMUST00000302682.1 ENSMUSG00000130896 (from geneSymbol) uc334psw.1 uc334psw.1 
ENSMUST00000302684.1 ENSMUSG00000130897 ENSMUST00000302684.1 ENSMUSG00000130897 (from geneSymbol) uc334psy.1 uc334psy.1 
ENSMUST00000302687.1 ENSMUSG00000130898 ENSMUST00000302687.1 ENSMUSG00000130898 (from geneSymbol) uc334ptb.1 uc334ptb.1 
ENSMUST00000302690.1 ENSMUSG00000130899 ENSMUST00000302690.1 ENSMUSG00000130899 (from geneSymbol) uc334pte.1 uc334pte.1 
ENSMUST00000302694.1 ENSMUSG00000130900 ENSMUST00000302694.1 ENSMUSG00000130900 (from geneSymbol) uc334pti.1 uc334pti.1 
ENSMUST00000302695.1 ENSMUSG00000130901 ENSMUST00000302695.1 ENSMUSG00000130901 (from geneSymbol) uc334ptj.1 uc334ptj.1 
ENSMUST00000302699.1 Gm33968 ENSMUST00000302699.1 Gm33968 (from geneSymbol) AK076739 uc334ptn.1 uc334ptn.1 
ENSMUST00000302717.1 ENSMUSG00000130902 ENSMUST00000302717.1 ENSMUSG00000130902 (from geneSymbol) uc334puf.1 uc334puf.1 
ENSMUST00000302721.1 ENSMUSG00000130903 ENSMUST00000302721.1 ENSMUSG00000130903 (from geneSymbol) uc334puj.1 uc334puj.1 
ENSMUST00000302723.1 ENSMUSG00000130904 ENSMUST00000302723.1 ENSMUSG00000130904 (from geneSymbol) uc334pul.1 uc334pul.1 
ENSMUST00000302725.1 ENSMUSG00000130906 ENSMUST00000302725.1 ENSMUSG00000130906 (from geneSymbol) uc334pum.1 uc334pum.1 
ENSMUST00000302726.1 4933428C19Rik ENSMUST00000302726.1 4933428C19Rik (from geneSymbol) AK016961 uc334pun.1 uc334pun.1 
ENSMUST00000302732.1 ENSMUSG00000130907 ENSMUST00000302732.1 ENSMUSG00000130907 (from geneSymbol) uc334put.1 uc334put.1 
ENSMUST00000302734.1 ENSMUSG00000130908 ENSMUST00000302734.1 ENSMUSG00000130908 (from geneSymbol) uc334puv.1 uc334puv.1 
ENSMUST00000302735.1 Gm36107 ENSMUST00000302735.1 Gm36107 (from geneSymbol) uc334puw.1 uc334puw.1 
ENSMUST00000302744.1 ENSMUSG00000130910 ENSMUST00000302744.1 ENSMUSG00000130910 (from geneSymbol) uc334pve.1 uc334pve.1 
ENSMUST00000302745.1 ENSMUSG00000130911 ENSMUST00000302745.1 ENSMUSG00000130911 (from geneSymbol) uc334pvf.1 uc334pvf.1 
ENSMUST00000302746.1 ENSMUSG00000130912 ENSMUST00000302746.1 ENSMUSG00000130912 (from geneSymbol) uc334pvg.1 uc334pvg.1 
ENSMUST00000302747.1 ENSMUSG00000130913 ENSMUST00000302747.1 ENSMUSG00000130913 (from geneSymbol) uc334pvh.1 uc334pvh.1 
ENSMUST00000302748.1 Gm32055 ENSMUST00000302748.1 Gm32055 (from geneSymbol) uc334pvi.1 uc334pvi.1 
ENSMUST00000302751.1 ENSMUSG00000130914 ENSMUST00000302751.1 ENSMUSG00000130914 (from geneSymbol) uc334pvl.1 uc334pvl.1 
ENSMUST00000302765.1 Gm49282 ENSMUST00000302765.1 Gm49282 (from geneSymbol) uc334pvz.1 uc334pvz.1 
ENSMUST00000302767.1 ENSMUSG00000130915 ENSMUST00000302767.1 ENSMUSG00000130915 (from geneSymbol) uc334pwb.1 uc334pwb.1 
ENSMUST00000302772.1 ENSMUSG00000130916 ENSMUST00000302772.1 ENSMUSG00000130916 (from geneSymbol) uc334pwg.1 uc334pwg.1 
ENSMUST00000302773.1 ENSMUSG00000130917 ENSMUST00000302773.1 ENSMUSG00000130917 (from geneSymbol) uc334pwh.1 uc334pwh.1 
ENSMUST00000302809.1 ENSMUSG00000130918 ENSMUST00000302809.1 ENSMUSG00000130918 (from geneSymbol) uc334pxr.1 uc334pxr.1 
ENSMUST00000302821.1 ENSMUSG00000130919 ENSMUST00000302821.1 ENSMUSG00000130919 (from geneSymbol) uc334pyd.1 uc334pyd.1 
ENSMUST00000302822.1 5430425K12Rik ENSMUST00000302822.1 5430425K12Rik (from geneSymbol) AK017339 uc334pye.1 uc334pye.1 
ENSMUST00000302825.1 ENSMUSG00000130920 ENSMUST00000302825.1 ENSMUSG00000130920 (from geneSymbol) uc334pyh.1 uc334pyh.1 
ENSMUST00000302831.1 ENSMUSG00000130921 ENSMUST00000302831.1 ENSMUSG00000130921 (from geneSymbol) uc334pyn.1 uc334pyn.1 
ENSMUST00000302834.1 Gm47716 ENSMUST00000302834.1 Gm47716 (from geneSymbol) uc334pyq.1 uc334pyq.1 
ENSMUST00000302836.1 ENSMUSG00000130922 ENSMUST00000302836.1 ENSMUSG00000130922 (from geneSymbol) uc334pys.1 uc334pys.1 
ENSMUST00000302838.1 ENSMUSG00000130923 ENSMUST00000302838.1 ENSMUSG00000130923 (from geneSymbol) uc334pyu.1 uc334pyu.1 
ENSMUST00000302847.1 ENSMUSG00000130924 ENSMUST00000302847.1 ENSMUSG00000130924 (from geneSymbol) uc334pzd.1 uc334pzd.1 
ENSMUST00000302848.1 ENSMUSG00000130925 ENSMUST00000302848.1 ENSMUSG00000130925 (from geneSymbol) uc334pze.1 uc334pze.1 
ENSMUST00000302855.1 ENSMUSG00000130926 ENSMUST00000302855.1 ENSMUSG00000130926 (from geneSymbol) uc334pzl.1 uc334pzl.1 
ENSMUST00000302857.1 ENSMUSG00000130927 ENSMUST00000302857.1 ENSMUSG00000130927 (from geneSymbol) uc334pzn.1 uc334pzn.1 
ENSMUST00000302859.1 ENSMUSG00000130928 ENSMUST00000302859.1 ENSMUSG00000130928 (from geneSymbol) uc334pzp.1 uc334pzp.1 
ENSMUST00000302862.1 ENSMUSG00000130929 ENSMUST00000302862.1 ENSMUSG00000130929 (from geneSymbol) uc334pzs.1 uc334pzs.1 
ENSMUST00000302865.1 ENSMUSG00000130930 ENSMUST00000302865.1 ENSMUSG00000130930 (from geneSymbol) uc334pzv.1 uc334pzv.1 
ENSMUST00000302866.1 ENSMUSG00000130931 ENSMUST00000302866.1 ENSMUSG00000130931 (from geneSymbol) uc334pzw.1 uc334pzw.1 
ENSMUST00000302871.1 Gm50340 ENSMUST00000302871.1 Gm50340 (from geneSymbol) KY467819 uc334qab.1 uc334qab.1 
ENSMUST00000302885.1 ENSMUSG00000130932 ENSMUST00000302885.1 ENSMUSG00000130932 (from geneSymbol) uc334qap.1 uc334qap.1 
ENSMUST00000302899.1 ENSMUSG00000130933 ENSMUST00000302899.1 ENSMUSG00000130933 (from geneSymbol) uc334qaz.1 uc334qaz.1 
ENSMUST00000302909.1 Gm55122 ENSMUST00000302909.1 Gm55122 (from geneSymbol) AK036048 uc334qbj.1 uc334qbj.1 
ENSMUST00000302928.1 ENSMUSG00000130934 ENSMUST00000302928.1 ENSMUSG00000130934 (from geneSymbol) uc334qcc.1 uc334qcc.1 
ENSMUST00000302935.1 ENSMUSG00000130935 ENSMUST00000302935.1 ENSMUSG00000130935 (from geneSymbol) uc334qcj.1 uc334qcj.1 
ENSMUST00000302936.1 ENSMUSG00000130936 ENSMUST00000302936.1 ENSMUSG00000130936 (from geneSymbol) uc334qck.1 uc334qck.1 
ENSMUST00000302941.1 ENSMUSG00000130937 ENSMUST00000302941.1 ENSMUSG00000130937 (from geneSymbol) uc334qcp.1 uc334qcp.1 
ENSMUST00000302942.1 ENSMUSG00000130938 ENSMUST00000302942.1 ENSMUSG00000130938 (from geneSymbol) uc334qcq.1 uc334qcq.1 
ENSMUST00000302943.1 Gm48975 ENSMUST00000302943.1 Gm48975 (from geneSymbol) uc334qcr.1 uc334qcr.1 
ENSMUST00000302944.1 ENSMUSG00000130939 ENSMUST00000302944.1 ENSMUSG00000130939 (from geneSymbol) uc334qcs.1 uc334qcs.1 
ENSMUST00000302945.1 Gm28077 ENSMUST00000302945.1 Gm28077 (from geneSymbol) uc334qct.1 uc334qct.1 
ENSMUST00000302948.1 ENSMUSG00000130940 ENSMUST00000302948.1 ENSMUSG00000130940 (from geneSymbol) uc334qcw.1 uc334qcw.1 
ENSMUST00000302959.1 Gm26611 ENSMUST00000302959.1 Gm26611 (from geneSymbol) AK076783 uc334qdf.1 uc334qdf.1 
ENSMUST00000302981.1 Gm50237 ENSMUST00000302981.1 Gm50237 (from geneSymbol) uc334qeb.1 uc334qeb.1 
ENSMUST00000302982.1 Gm27168 ENSMUST00000302982.1 Gm27168 (from geneSymbol) uc334qec.1 uc334qec.1 
ENSMUST00000302992.1 ENSMUSG00000130941 ENSMUST00000302992.1 ENSMUSG00000130941 (from geneSymbol) uc334qem.1 uc334qem.1 
ENSMUST00000302993.1 ENSMUSG00000130942 ENSMUST00000302993.1 ENSMUSG00000130942 (from geneSymbol) uc334qen.1 uc334qen.1 
ENSMUST00000302994.1 ENSMUSG00000130943 ENSMUST00000302994.1 ENSMUSG00000130943 (from geneSymbol) uc334qeo.1 uc334qeo.1 
ENSMUST00000302995.1 ENSMUSG00000130944 ENSMUST00000302995.1 ENSMUSG00000130944 (from geneSymbol) uc334qep.1 uc334qep.1 
ENSMUST00000302997.1 ENSMUSG00000130945 ENSMUST00000302997.1 ENSMUSG00000130945 (from geneSymbol) uc334qer.1 uc334qer.1 
ENSMUST00000302998.1 ENSMUSG00000130946 ENSMUST00000302998.1 ENSMUSG00000130946 (from geneSymbol) uc334qes.1 uc334qes.1 
ENSMUST00000302999.1 ENSMUSG00000130947 ENSMUST00000302999.1 predicted gene, 45913 (from RefSeq NR_152163.1) NR_152163 uc334qet.1 uc334qet.1 
ENSMUST00000303000.1 ENSMUSG00000130948 ENSMUST00000303000.1 ENSMUSG00000130948 (from geneSymbol) AK143961 uc334qeu.1 uc334qeu.1 
ENSMUST00000303008.1 ENSMUSG00000130949 ENSMUST00000303008.1 ENSMUSG00000130949 (from geneSymbol) uc334qfc.1 uc334qfc.1 
ENSMUST00000303015.1 ENSMUSG00000130950 ENSMUST00000303015.1 ENSMUSG00000130950 (from geneSymbol) uc334qfj.1 uc334qfj.1 
ENSMUST00000303016.1 ENSMUSG00000130951 ENSMUST00000303016.1 ENSMUSG00000130951 (from geneSymbol) uc334qfk.1 uc334qfk.1 
ENSMUST00000303018.1 ENSMUSG00000130952 ENSMUST00000303018.1 ENSMUSG00000130952 (from geneSymbol) uc334qfm.1 uc334qfm.1 
ENSMUST00000303019.1 ENSMUSG00000130953 ENSMUST00000303019.1 ENSMUSG00000130953 (from geneSymbol) uc334qfn.1 uc334qfn.1 
ENSMUST00000303020.1 ENSMUSG00000130954 ENSMUST00000303020.1 ENSMUSG00000130954 (from geneSymbol) uc334qfo.1 uc334qfo.1 
ENSMUST00000303025.1 4931420L22Rik ENSMUST00000303025.1 4931420L22Rik (from geneSymbol) AK016468 uc334qft.1 uc334qft.1 
ENSMUST00000303061.1 Gm42921 ENSMUST00000303061.1 Gm42921 (from geneSymbol) uc334qhd.1 uc334qhd.1 
ENSMUST00000303073.1 ENSMUSG00000130955 ENSMUST00000303073.1 ENSMUSG00000130955 (from geneSymbol) uc334qhp.1 uc334qhp.1 
ENSMUST00000303074.1 ENSMUSG00000130956 ENSMUST00000303074.1 ENSMUSG00000130956 (from geneSymbol) uc334qhq.1 uc334qhq.1 
ENSMUST00000303078.1 ENSMUSG00000121869 ENSMUST00000303078.1 ENSMUSG00000121869 (from geneSymbol) AK138215 uc334qhu.1 uc334qhu.1 
ENSMUST00000303113.1 ENSMUSG00000130957 ENSMUST00000303113.1 ENSMUSG00000130957 (from geneSymbol) uc334qjd.1 uc334qjd.1 
ENSMUST00000303117.1 ENSMUSG00000130958 ENSMUST00000303117.1 ENSMUSG00000130958 (from geneSymbol) uc334qjh.1 uc334qjh.1 
ENSMUST00000303119.1 ENSMUSG00000130959 ENSMUST00000303119.1 ENSMUSG00000130959 (from geneSymbol) uc334qjj.1 uc334qjj.1 
ENSMUST00000303124.1 ENSMUSG00000130961 ENSMUST00000303124.1 ENSMUSG00000130961 (from geneSymbol) uc334qjn.1 uc334qjn.1 
ENSMUST00000303130.1 ENSMUSG00000130962 ENSMUST00000303130.1 ENSMUSG00000130962 (from geneSymbol) uc334qjt.1 uc334qjt.1 
ENSMUST00000303131.1 ENSMUSG00000130963 ENSMUST00000303131.1 ENSMUSG00000130963 (from geneSymbol) uc334qju.1 uc334qju.1 
ENSMUST00000303134.1 ENSMUSG00000130964 ENSMUST00000303134.1 ENSMUSG00000130964 (from geneSymbol) uc334qjx.1 uc334qjx.1 
ENSMUST00000303135.1 ENSMUSG00000130965 ENSMUST00000303135.1 ENSMUSG00000130965 (from geneSymbol) uc334qjy.1 uc334qjy.1 
ENSMUST00000303147.1 Gm36913 ENSMUST00000303147.1 predicted gene, 36913, transcript variant 2 (from RefSeq NR_176648.1) NR_176648 uc334qkk.1 uc334qkk.1 
ENSMUST00000303167.1 ENSMUSG00000130967 ENSMUST00000303167.1 ENSMUSG00000130967 (from geneSymbol) uc334qld.1 uc334qld.1 
ENSMUST00000303170.1 ENSMUSG00000130968 ENSMUST00000303170.1 ENSMUSG00000130968 (from geneSymbol) uc334qlg.1 uc334qlg.1 
ENSMUST00000303174.1 ENSMUSG00000130969 ENSMUST00000303174.1 ENSMUSG00000130969 (from geneSymbol) uc334qlk.1 uc334qlk.1 
ENSMUST00000303177.1 ENSMUSG00000130970 ENSMUST00000303177.1 ENSMUSG00000130970 (from geneSymbol) uc334qln.1 uc334qln.1 
ENSMUST00000303178.1 ENSMUSG00000130971 ENSMUST00000303178.1 ENSMUSG00000130971 (from geneSymbol) uc334qlo.1 uc334qlo.1 
ENSMUST00000303179.1 ENSMUSG00000130972 ENSMUST00000303179.1 ENSMUSG00000130972 (from geneSymbol) uc334qlp.1 uc334qlp.1 
ENSMUST00000303181.1 ENSMUSG00000130973 ENSMUST00000303181.1 ENSMUSG00000130973 (from geneSymbol) uc334qlr.1 uc334qlr.1 
ENSMUST00000303182.1 ENSMUSG00000130974 ENSMUST00000303182.1 ENSMUSG00000130974 (from geneSymbol) uc334qls.1 uc334qls.1 
ENSMUST00000303237.1 ENSMUSG00000130975 ENSMUST00000303237.1 ENSMUSG00000130975 (from geneSymbol) uc334qnu.1 uc334qnu.1 
ENSMUST00000303248.1 ENSMUSG00000130976 ENSMUST00000303248.1 ENSMUSG00000130976 (from geneSymbol) uc334qof.1 uc334qof.1 
ENSMUST00000303249.1 ENSMUSG00000130977 ENSMUST00000303249.1 ENSMUSG00000130977 (from geneSymbol) uc334qog.1 uc334qog.1 
ENSMUST00000303251.1 ENSMUSG00000130978 ENSMUST00000303251.1 ENSMUSG00000130978 (from geneSymbol) uc334qoh.1 uc334qoh.1 
ENSMUST00000303255.1 ENSMUSG00000130979 ENSMUST00000303255.1 ENSMUSG00000130979 (from geneSymbol) uc334qol.1 uc334qol.1 
ENSMUST00000303257.1 Gm5373 ENSMUST00000303257.1 Gm5373 (from geneSymbol) uc334qon.1 uc334qon.1 
ENSMUST00000303268.1 Gm2396 ENSMUST00000303268.1 Gm2396 (from geneSymbol) uc334qoy.1 uc334qoy.1 
ENSMUST00000303275.1 ENSMUSG00000130980 ENSMUST00000303275.1 ENSMUSG00000130980 (from geneSymbol) uc334qpf.1 uc334qpf.1 
ENSMUST00000303289.1 Gm11772 ENSMUST00000303289.1 Gm11772 (from geneSymbol) uc334qpt.1 uc334qpt.1 
ENSMUST00000303290.1 ENSMUSG00000130981 ENSMUST00000303290.1 ENSMUSG00000130981 (from geneSymbol) uc334qpu.1 uc334qpu.1 
ENSMUST00000303297.1 Sfta3-ps ENSMUST00000303297.1 Sfta3-ps (from geneSymbol) KF856953 uc334qqb.1 uc334qqb.1 
ENSMUST00000303314.1 ENSMUSG00000130982 ENSMUST00000303314.1 ENSMUSG00000130982 (from geneSymbol) uc334qqq.1 uc334qqq.1 
ENSMUST00000303316.1 ENSMUSG00000130983 ENSMUST00000303316.1 ENSMUSG00000130983 (from geneSymbol) uc334qqs.1 uc334qqs.1 
ENSMUST00000303317.1 ENSMUSG00000130984 ENSMUST00000303317.1 ENSMUSG00000130984 (from geneSymbol) uc334qqt.1 uc334qqt.1 
ENSMUST00000303318.1 ENSMUSG00000130985 ENSMUST00000303318.1 ENSMUSG00000130985 (from geneSymbol) uc334qqu.1 uc334qqu.1 
ENSMUST00000303322.1 ENSMUSG00000130986 ENSMUST00000303322.1 ENSMUSG00000130986 (from geneSymbol) uc334qqy.1 uc334qqy.1 
ENSMUST00000303323.1 ENSMUSG00000130987 ENSMUST00000303323.1 ENSMUSG00000130987 (from geneSymbol) uc334qqz.1 uc334qqz.1 
ENSMUST00000303326.1 ENSMUSG00000130988 ENSMUST00000303326.1 ENSMUSG00000130988 (from geneSymbol) uc334qrc.1 uc334qrc.1 
ENSMUST00000303327.1 ENSMUSG00000130989 ENSMUST00000303327.1 ENSMUSG00000130989 (from geneSymbol) uc334qrd.1 uc334qrd.1 
ENSMUST00000303330.1 ENSMUSG00000130990 ENSMUST00000303330.1 ENSMUSG00000130990 (from geneSymbol) uc334qrg.1 uc334qrg.1 
ENSMUST00000303332.1 ENSMUSG00000130991 ENSMUST00000303332.1 ENSMUSG00000130991 (from geneSymbol) uc334qri.1 uc334qri.1 
ENSMUST00000303335.1 Pax6os1 ENSMUST00000303335.1 Pax6os1 (from geneSymbol) AK029183 uc334qrl.1 uc334qrl.1 
ENSMUST00000303341.1 Gm46120 ENSMUST00000303341.1 Gm46120 (from geneSymbol) uc334qrr.1 uc334qrr.1 
ENSMUST00000303345.1 ENSMUSG00000130992 ENSMUST00000303345.1 ENSMUSG00000130992 (from geneSymbol) uc334qrv.1 uc334qrv.1 
ENSMUST00000303346.1 ENSMUSG00000130993 ENSMUST00000303346.1 ENSMUSG00000130993 (from geneSymbol) uc334qrw.1 uc334qrw.1 
ENSMUST00000303348.1 ENSMUSG00000130994 ENSMUST00000303348.1 ENSMUSG00000130994 (from geneSymbol) uc334qrx.1 uc334qrx.1 
ENSMUST00000303354.1 ENSMUSG00000130995 ENSMUST00000303354.1 ENSMUSG00000130995 (from geneSymbol) uc334qsd.1 uc334qsd.1 
ENSMUST00000303394.1 ENSMUSG00000130996 ENSMUST00000303394.1 ENSMUSG00000130996 (from geneSymbol) uc334qtr.1 uc334qtr.1 
ENSMUST00000303399.1 ENSMUSG00000130997 ENSMUST00000303399.1 ENSMUSG00000130997 (from geneSymbol) uc334qtw.1 uc334qtw.1 
ENSMUST00000303400.1 ENSMUSG00000130998 ENSMUST00000303400.1 ENSMUSG00000130998 (from geneSymbol) uc334qtx.1 uc334qtx.1 
ENSMUST00000303402.1 ENSMUSG00000130999 ENSMUST00000303402.1 ENSMUSG00000130999 (from geneSymbol) uc334qtz.1 uc334qtz.1 
ENSMUST00000303407.1 ENSMUSG00000131000 ENSMUST00000303407.1 ENSMUSG00000131000 (from geneSymbol) uc334que.1 uc334que.1 
ENSMUST00000303409.1 ENSMUSG00000131001 ENSMUST00000303409.1 ENSMUSG00000131001 (from geneSymbol) uc334qug.1 uc334qug.1 
ENSMUST00000303410.1 4930474M22Rik ENSMUST00000303410.1 4930474M22Rik (from geneSymbol) BC089489 uc334quh.1 uc334quh.1 
ENSMUST00000303415.1 ENSMUSG00000131003 ENSMUST00000303415.1 ENSMUSG00000131003 (from geneSymbol) uc334qul.1 uc334qul.1 
ENSMUST00000303417.1 ENSMUSG00000131004 ENSMUST00000303417.1 ENSMUSG00000131004 (from geneSymbol) uc334qun.1 uc334qun.1 
ENSMUST00000303422.1 Gm36393 ENSMUST00000303422.1 Gm36393 (from geneSymbol) KY467868 uc334qus.1 uc334qus.1 
ENSMUST00000303441.1 ENSMUSG00000131005 ENSMUST00000303441.1 ENSMUSG00000131005 (from geneSymbol) uc334qvl.1 uc334qvl.1 
ENSMUST00000303445.1 ENSMUSG00000131006 ENSMUST00000303445.1 ENSMUSG00000131006 (from geneSymbol) uc334qvp.1 uc334qvp.1 
ENSMUST00000303446.1 ENSMUSG00000131007 ENSMUST00000303446.1 ENSMUSG00000131007 (from geneSymbol) uc334qvq.1 uc334qvq.1 
ENSMUST00000303450.1 ENSMUSG00000131008 ENSMUST00000303450.1 ENSMUSG00000131008 (from geneSymbol) uc334qvu.1 uc334qvu.1 
ENSMUST00000303467.1 ENSMUSG00000131009 ENSMUST00000303467.1 ENSMUSG00000131009 (from geneSymbol) uc334qwl.1 uc334qwl.1 
ENSMUST00000303469.1 ENSMUSG00000131010 ENSMUST00000303469.1 ENSMUSG00000131010 (from geneSymbol) uc334qwn.1 uc334qwn.1 
ENSMUST00000303472.1 ENSMUSG00000131011 ENSMUST00000303472.1 ENSMUSG00000131011 (from geneSymbol) uc334qwq.1 uc334qwq.1 
ENSMUST00000303473.1 ENSMUSG00000131012 ENSMUST00000303473.1 ENSMUSG00000131012 (from geneSymbol) uc334qwr.1 uc334qwr.1 
ENSMUST00000303474.1 ENSMUSG00000131013 ENSMUST00000303474.1 ENSMUSG00000131013 (from geneSymbol) uc334qws.1 uc334qws.1 
ENSMUST00000303475.1 ENSMUSG00000131014 ENSMUST00000303475.1 ENSMUSG00000131014 (from geneSymbol) uc334qwt.1 uc334qwt.1 
ENSMUST00000303476.1 ENSMUSG00000131015 ENSMUST00000303476.1 ENSMUSG00000131015 (from geneSymbol) uc334qwu.1 uc334qwu.1 
ENSMUST00000303480.1 ENSMUSG00000131016 ENSMUST00000303480.1 ENSMUSG00000131016 (from geneSymbol) uc334qwy.1 uc334qwy.1 
ENSMUST00000303492.1 Gm10634 ENSMUST00000303492.1 Gm10634 (from geneSymbol) AK077175 uc334qxj.1 uc334qxj.1 
ENSMUST00000303499.1 ENSMUSG00000131017 ENSMUST00000303499.1 ENSMUSG00000131017 (from geneSymbol) uc334qxq.1 uc334qxq.1 
ENSMUST00000303500.1 ENSMUSG00000131018 ENSMUST00000303500.1 ENSMUSG00000131018 (from geneSymbol) uc334qxr.1 uc334qxr.1 
ENSMUST00000303503.1 ENSMUSG00000131019 ENSMUST00000303503.1 ENSMUSG00000131019 (from geneSymbol) DQ722109 uc334qxu.1 uc334qxu.1 
ENSMUST00000303504.1 ENSMUSG00000131020 ENSMUST00000303504.1 ENSMUSG00000131020 (from geneSymbol) uc334qxv.1 uc334qxv.1 
ENSMUST00000303511.1 Gm53435 ENSMUST00000303511.1 Gm53435 (from geneSymbol) uc334qyc.1 uc334qyc.1 
ENSMUST00000303522.1 ENSMUSG00000131021 ENSMUST00000303522.1 ENSMUSG00000131021 (from geneSymbol) uc334qyn.1 uc334qyn.1 
ENSMUST00000303528.1 ENSMUSG00000131022 ENSMUST00000303528.1 ENSMUSG00000131022 (from geneSymbol) uc334qyt.1 uc334qyt.1 
ENSMUST00000303530.1 Gm45169 ENSMUST00000303530.1 Gm45169 (from geneSymbol) AK086341 uc334qyv.1 uc334qyv.1 
ENSMUST00000303531.1 ENSMUSG00000131023 ENSMUST00000303531.1 ENSMUSG00000131023 (from geneSymbol) uc334qyw.1 uc334qyw.1 
ENSMUST00000303532.1 ENSMUSG00000131024 ENSMUST00000303532.1 ENSMUSG00000131024 (from geneSymbol) LF200304 uc334qyx.1 uc334qyx.1 
ENSMUST00000303534.1 ENSMUSG00000131025 ENSMUST00000303534.1 ENSMUSG00000131025 (from geneSymbol) uc334qyz.1 uc334qyz.1 
ENSMUST00000303535.1 ENSMUSG00000131026 ENSMUST00000303535.1 ENSMUSG00000131026 (from geneSymbol) uc334qza.1 uc334qza.1 
ENSMUST00000303536.1 ENSMUSG00000131027 ENSMUST00000303536.1 ENSMUSG00000131027 (from geneSymbol) uc334qzb.1 uc334qzb.1 
ENSMUST00000303537.1 ENSMUSG00000131028 ENSMUST00000303537.1 ENSMUSG00000131028 (from geneSymbol) uc334qzc.1 uc334qzc.1 
ENSMUST00000303540.1 4930527A07Rik ENSMUST00000303540.1 4930527A07Rik (from geneSymbol) AK015909 uc334qzf.1 uc334qzf.1 
ENSMUST00000303543.1 ENSMUSG00000131029 ENSMUST00000303543.1 ENSMUSG00000131029 (from geneSymbol) uc334qzi.1 uc334qzi.1 
ENSMUST00000303545.1 ENSMUSG00000131030 ENSMUST00000303545.1 ENSMUSG00000131030 (from geneSymbol) uc334qzk.1 uc334qzk.1 
ENSMUST00000303549.1 Gm29686 ENSMUST00000303549.1 Gm29686 (from geneSymbol) AK157531 uc334qzo.1 uc334qzo.1 
ENSMUST00000303562.1 ENSMUSG00000131031 ENSMUST00000303562.1 ENSMUSG00000131031 (from geneSymbol) uc334rab.1 uc334rab.1 
ENSMUST00000303567.1 ENSMUSG00000131032 ENSMUST00000303567.1 ENSMUSG00000131032 (from geneSymbol) uc334rag.1 uc334rag.1 
ENSMUST00000303573.1 ENSMUSG00000131033 ENSMUST00000303573.1 ENSMUSG00000131033 (from geneSymbol) uc334ram.1 uc334ram.1 
ENSMUST00000303578.1 ENSMUSG00000131034 ENSMUST00000303578.1 ENSMUSG00000131034 (from geneSymbol) uc334rar.1 uc334rar.1 
ENSMUST00000303579.1 ENSMUSG00000131035 ENSMUST00000303579.1 ENSMUSG00000131035 (from geneSymbol) uc334ras.1 uc334ras.1 
ENSMUST00000303584.1 ENSMUSG00000131036 ENSMUST00000303584.1 ENSMUSG00000131036 (from geneSymbol) uc334rax.1 uc334rax.1 
ENSMUST00000303585.1 Gm26627 ENSMUST00000303585.1 Gm26627 (from geneSymbol) AK084376 uc334ray.1 uc334ray.1 
ENSMUST00000303590.1 ENSMUSG00000131037 ENSMUST00000303590.1 ENSMUSG00000131037 (from geneSymbol) uc334rbd.1 uc334rbd.1 
ENSMUST00000303591.1 ENSMUSG00000131038 ENSMUST00000303591.1 ENSMUSG00000131038 (from geneSymbol) uc334rbe.1 uc334rbe.1 
ENSMUST00000303592.1 Gm38947 ENSMUST00000303592.1 Gm38947 (from geneSymbol) AK133700 uc334rbf.1 uc334rbf.1 
ENSMUST00000303598.1 4930599N23Rik ENSMUST00000303598.1 4930599N23Rik (from geneSymbol) AK016417 uc334rbk.1 uc334rbk.1 
ENSMUST00000303608.1 ENSMUSG00000131039 ENSMUST00000303608.1 ENSMUSG00000131039 (from geneSymbol) uc334rbu.1 uc334rbu.1 
ENSMUST00000303610.1 Gm35077 ENSMUST00000303610.1 Gm35077 (from geneSymbol) AK007069 uc334rbw.1 uc334rbw.1 
ENSMUST00000303625.1 Gm15756 ENSMUST00000303625.1 Gm15756 (from geneSymbol) BC100523 uc334rcl.1 uc334rcl.1 
ENSMUST00000303641.1 ENSMUSG00000131040 ENSMUST00000303641.1 ENSMUSG00000131040 (from geneSymbol) uc334rdb.1 uc334rdb.1 
ENSMUST00000303642.1 ENSMUSG00000131041 ENSMUST00000303642.1 ENSMUSG00000131041 (from geneSymbol) uc334rdc.1 uc334rdc.1 
ENSMUST00000303644.1 ENSMUSG00000131042 ENSMUST00000303644.1 ENSMUSG00000131042 (from geneSymbol) uc334rde.1 uc334rde.1 
ENSMUST00000303647.1 ENSMUSG00000131044 ENSMUST00000303647.1 ENSMUSG00000131044 (from geneSymbol) uc334rdg.1 uc334rdg.1 
ENSMUST00000303652.1 ENSMUSG00000131045 ENSMUST00000303652.1 ENSMUSG00000131045 (from geneSymbol) uc334rdl.1 uc334rdl.1 
ENSMUST00000303674.1 ENSMUSG00000131046 ENSMUST00000303674.1 ENSMUSG00000131046 (from geneSymbol) uc334reh.1 uc334reh.1 
ENSMUST00000303677.1 ENSMUSG00000131047 ENSMUST00000303677.1 ENSMUSG00000131047 (from geneSymbol) KY468261 uc334rek.1 uc334rek.1 
ENSMUST00000303684.1 ENSMUSG00000131048 ENSMUST00000303684.1 ENSMUSG00000131048 (from geneSymbol) uc334rer.1 uc334rer.1 
ENSMUST00000303685.1 ENSMUSG00000131049 ENSMUST00000303685.1 ENSMUSG00000131049 (from geneSymbol) uc334res.1 uc334res.1 
ENSMUST00000303688.1 ENSMUSG00000131050 ENSMUST00000303688.1 ENSMUSG00000131050 (from geneSymbol) uc334rev.1 uc334rev.1 
ENSMUST00000303692.1 9130410C08Rik ENSMUST00000303692.1 9130410C08Rik (from geneSymbol) AK018667 uc334rez.1 uc334rez.1 
ENSMUST00000303698.1 Gm26630 ENSMUST00000303698.1 Gm26630 (from geneSymbol) AK076622 uc334rff.1 uc334rff.1 
ENSMUST00000303704.1 ENSMUSG00000131051 ENSMUST00000303704.1 ENSMUSG00000131051 (from geneSymbol) uc334rfl.1 uc334rfl.1 
ENSMUST00000303705.1 ENSMUSG00000131052 ENSMUST00000303705.1 ENSMUSG00000131052 (from geneSymbol) uc334rfm.1 uc334rfm.1 
ENSMUST00000303706.1 ENSMUSG00000131053 ENSMUST00000303706.1 ENSMUSG00000131053 (from geneSymbol) uc334rfn.1 uc334rfn.1 
ENSMUST00000303712.1 ENSMUSG00000131054 ENSMUST00000303712.1 ENSMUSG00000131054 (from geneSymbol) uc334rft.1 uc334rft.1 
ENSMUST00000303714.1 ENSMUSG00000131055 ENSMUST00000303714.1 ENSMUSG00000131055 (from geneSymbol) uc334rfv.1 uc334rfv.1 
ENSMUST00000303716.1 9330159M07Rik ENSMUST00000303716.1 9330159M07Rik (from geneSymbol) AK007093 uc334rfx.1 uc334rfx.1 
ENSMUST00000303775.1 4930513D17Rik ENSMUST00000303775.1 4930513D17Rik (from geneSymbol) AK132902 uc334rie.1 uc334rie.1 
ENSMUST00000303781.1 ENSMUSG00000131056 ENSMUST00000303781.1 ENSMUSG00000131056 (from geneSymbol) uc334rik.1 uc334rik.1 
ENSMUST00000303782.1 ENSMUSG00000131057 ENSMUST00000303782.1 ENSMUSG00000131057 (from geneSymbol) uc334ril.1 uc334ril.1 
ENSMUST00000303785.1 ENSMUSG00000131058 ENSMUST00000303785.1 ENSMUSG00000131058 (from geneSymbol) uc334rio.1 uc334rio.1 
ENSMUST00000303786.1 ENSMUSG00000131059 ENSMUST00000303786.1 ENSMUSG00000131059 (from geneSymbol) uc334rip.1 uc334rip.1 
ENSMUST00000303788.1 ENSMUSG00000131060 ENSMUST00000303788.1 ENSMUSG00000131060 (from geneSymbol) uc334rir.1 uc334rir.1 
ENSMUST00000303789.1 ENSMUSG00000131061 ENSMUST00000303789.1 ENSMUSG00000131061 (from geneSymbol) uc334ris.1 uc334ris.1 
ENSMUST00000303794.1 ENSMUSG00000131062 ENSMUST00000303794.1 ENSMUSG00000131062 (from geneSymbol) uc334rix.1 uc334rix.1 
ENSMUST00000303798.1 ENSMUSG00000131064 ENSMUST00000303798.1 ENSMUSG00000131064 (from geneSymbol) uc334rja.1 uc334rja.1 
ENSMUST00000303799.1 ENSMUSG00000131065 ENSMUST00000303799.1 ENSMUSG00000131065 (from geneSymbol) uc334rjb.1 uc334rjb.1 
ENSMUST00000303803.1 ENSMUSG00000131066 ENSMUST00000303803.1 ENSMUSG00000131066 (from geneSymbol) uc334rjf.1 uc334rjf.1 
ENSMUST00000303804.1 ENSMUSG00000131067 ENSMUST00000303804.1 ENSMUSG00000131067 (from geneSymbol) uc334rjg.1 uc334rjg.1 
ENSMUST00000303807.1 ENSMUSG00000131068 ENSMUST00000303807.1 ENSMUSG00000131068 (from geneSymbol) uc334rjj.1 uc334rjj.1 
ENSMUST00000303808.1 ENSMUSG00000131069 ENSMUST00000303808.1 ENSMUSG00000131069 (from geneSymbol) uc334rjk.1 uc334rjk.1 
ENSMUST00000303810.1 ENSMUSG00000131070 ENSMUST00000303810.1 ENSMUSG00000131070 (from geneSymbol) uc334rjm.1 uc334rjm.1 
ENSMUST00000303813.1 ENSMUSG00000131071 ENSMUST00000303813.1 ENSMUSG00000131071 (from geneSymbol) uc334rjp.1 uc334rjp.1 
ENSMUST00000303814.1 ENSMUSG00000131072 ENSMUST00000303814.1 ENSMUSG00000131072 (from geneSymbol) uc334rjq.1 uc334rjq.1 
ENSMUST00000303816.1 ENSMUSG00000131073 ENSMUST00000303816.1 ENSMUSG00000131073 (from geneSymbol) BC089498 uc334rjs.1 uc334rjs.1 
ENSMUST00000303817.1 ENSMUSG00000131074 ENSMUST00000303817.1 ENSMUSG00000131074 (from geneSymbol) uc334rjt.1 uc334rjt.1 
ENSMUST00000303821.1 ENSMUSG00000131075 ENSMUST00000303821.1 ENSMUSG00000131075 (from geneSymbol) uc334rjx.1 uc334rjx.1 
ENSMUST00000303824.1 ENSMUSG00000131076 ENSMUST00000303824.1 ENSMUSG00000131076 (from geneSymbol) uc334rka.1 uc334rka.1 
ENSMUST00000303831.1 ENSMUSG00000131077 ENSMUST00000303831.1 ENSMUSG00000131077 (from geneSymbol) uc334rkh.1 uc334rkh.1 
ENSMUST00000303838.1 Gm56632 ENSMUST00000303838.1 Gm56632 (from geneSymbol) uc334rko.1 uc334rko.1 
ENSMUST00000303842.1 ENSMUSG00000131078 ENSMUST00000303842.1 ENSMUSG00000131078 (from geneSymbol) uc334rks.1 uc334rks.1 
ENSMUST00000303847.1 ENSMUSG00000131079 ENSMUST00000303847.1 ENSMUSG00000131079 (from geneSymbol) uc334rkx.1 uc334rkx.1 
ENSMUST00000303848.1 ENSMUSG00000131080 ENSMUST00000303848.1 ENSMUSG00000131080 (from geneSymbol) uc334rky.1 uc334rky.1 
ENSMUST00000303849.1 ENSMUSG00000131081 ENSMUST00000303849.1 ENSMUSG00000131081 (from geneSymbol) AK042693 uc334rkz.1 uc334rkz.1 
ENSMUST00000303850.1 ENSMUSG00000131082 ENSMUST00000303850.1 ENSMUSG00000131082 (from geneSymbol) uc334rla.1 uc334rla.1 
ENSMUST00000303851.1 ENSMUSG00000131083 ENSMUST00000303851.1 ENSMUSG00000131083 (from geneSymbol) uc334rlb.1 uc334rlb.1 
ENSMUST00000303857.1 ENSMUSG00000131085 ENSMUST00000303857.1 ENSMUSG00000131085 (from geneSymbol) uc334rlg.1 uc334rlg.1 
ENSMUST00000303861.1 ENSMUSG00000131086 ENSMUST00000303861.1 ENSMUSG00000131086 (from geneSymbol) uc334rlk.1 uc334rlk.1 
ENSMUST00000303864.1 ENSMUSG00000131087 ENSMUST00000303864.1 ENSMUSG00000131087 (from geneSymbol) uc334rln.1 uc334rln.1 
ENSMUST00000303865.1 ENSMUSG00000131088 ENSMUST00000303865.1 ENSMUSG00000131088 (from geneSymbol) uc334rlo.1 uc334rlo.1 
ENSMUST00000303870.1 ENSMUSG00000131089 ENSMUST00000303870.1 ENSMUSG00000131089 (from geneSymbol) uc334rlt.1 uc334rlt.1 
ENSMUST00000303903.1 ENSMUSG00000131090 ENSMUST00000303903.1 ENSMUSG00000131090 (from geneSymbol) uc334rna.1 uc334rna.1 
ENSMUST00000303909.1 ENSMUSG00000131091 ENSMUST00000303909.1 ENSMUSG00000131091 (from geneSymbol) uc334rng.1 uc334rng.1 
ENSMUST00000303930.1 ENSMUSG00000131092 ENSMUST00000303930.1 ENSMUSG00000131092 (from geneSymbol) uc334rob.1 uc334rob.1 
ENSMUST00000303935.1 ENSMUSG00000131093 ENSMUST00000303935.1 ENSMUSG00000131093 (from geneSymbol) uc334rog.1 uc334rog.1 
ENSMUST00000303954.1 Gm4035 ENSMUST00000303954.1 Gm4035 (from geneSymbol) AK079953 uc334roz.1 uc334roz.1 
ENSMUST00000303968.1 ENSMUSG00000131094 ENSMUST00000303968.1 ENSMUSG00000131094 (from geneSymbol) uc334rpn.1 uc334rpn.1 
ENSMUST00000303969.1 ENSMUSG00000131095 ENSMUST00000303969.1 ENSMUSG00000131095 (from geneSymbol) uc334rpo.1 uc334rpo.1 
ENSMUST00000303970.1 ENSMUSG00000131096 ENSMUST00000303970.1 ENSMUSG00000131096 (from geneSymbol) uc334rpp.1 uc334rpp.1 
ENSMUST00000303972.1 ENSMUSG00000131097 ENSMUST00000303972.1 ENSMUSG00000131097 (from geneSymbol) uc334rpr.1 uc334rpr.1 
ENSMUST00000303981.1 ENSMUSG00000131098 ENSMUST00000303981.1 ENSMUSG00000131098 (from geneSymbol) uc334rqa.1 uc334rqa.1 
ENSMUST00000303984.1 1700065I16Rik ENSMUST00000303984.1 1700065I16Rik (from geneSymbol) AK018879 uc334rqd.1 uc334rqd.1 
ENSMUST00000303996.1 ENSMUSG00000131099 ENSMUST00000303996.1 ENSMUSG00000131099 (from geneSymbol) uc334rqp.1 uc334rqp.1 
ENSMUST00000303997.1 ENSMUSG00000131100 ENSMUST00000303997.1 ENSMUSG00000131100 (from geneSymbol) uc334rqq.1 uc334rqq.1 
ENSMUST00000303998.1 ENSMUSG00000131101 ENSMUST00000303998.1 ENSMUSG00000131101 (from geneSymbol) uc334rqr.1 uc334rqr.1 
ENSMUST00000304000.1 ENSMUSG00000131102 ENSMUST00000304000.1 ENSMUSG00000131102 (from geneSymbol) uc334rqt.1 uc334rqt.1 
ENSMUST00000304011.1 ENSMUSG00000131103 ENSMUST00000304011.1 ENSMUSG00000131103 (from geneSymbol) uc334rre.1 uc334rre.1 
ENSMUST00000304018.1 ENSMUSG00000131104 ENSMUST00000304018.1 ENSMUSG00000131104 (from geneSymbol) uc334rrl.1 uc334rrl.1 
ENSMUST00000304020.1 ENSMUSG00000131105 ENSMUST00000304020.1 ENSMUSG00000131105 (from geneSymbol) uc334rrn.1 uc334rrn.1 
ENSMUST00000304021.1 ENSMUSG00000131106 ENSMUST00000304021.1 ENSMUSG00000131106 (from geneSymbol) uc334rro.1 uc334rro.1 
ENSMUST00000304025.1 ENSMUSG00000131107 ENSMUST00000304025.1 ENSMUSG00000131107 (from geneSymbol) uc334rrs.1 uc334rrs.1 
ENSMUST00000304026.1 ENSMUSG00000131108 ENSMUST00000304026.1 ENSMUSG00000131108 (from geneSymbol) uc334rrt.1 uc334rrt.1 
ENSMUST00000304028.1 ENSMUSG00000131109 ENSMUST00000304028.1 ENSMUSG00000131109 (from geneSymbol) uc334rrv.1 uc334rrv.1 
ENSMUST00000304030.1 ENSMUSG00000131110 ENSMUST00000304030.1 ENSMUSG00000131110 (from geneSymbol) uc334rrx.1 uc334rrx.1 
ENSMUST00000304031.1 ENSMUSG00000131111 ENSMUST00000304031.1 ENSMUSG00000131111 (from geneSymbol) uc334rry.1 uc334rry.1 
ENSMUST00000304032.1 ENSMUSG00000131112 ENSMUST00000304032.1 ENSMUSG00000131112 (from geneSymbol) uc334rrz.1 uc334rrz.1 
ENSMUST00000304033.1 ENSMUSG00000131113 ENSMUST00000304033.1 ENSMUSG00000131113 (from geneSymbol) uc334rsa.1 uc334rsa.1 
ENSMUST00000304034.1 ENSMUSG00000131114 ENSMUST00000304034.1 ENSMUSG00000131114 (from geneSymbol) uc334rsb.1 uc334rsb.1 
ENSMUST00000304035.1 ENSMUSG00000131115 ENSMUST00000304035.1 ENSMUSG00000131115 (from geneSymbol) uc334rsc.1 uc334rsc.1 
ENSMUST00000304037.1 ENSMUSG00000131117 ENSMUST00000304037.1 ENSMUSG00000131117 (from geneSymbol) uc334rsd.1 uc334rsd.1 
ENSMUST00000304038.1 Gm2479 ENSMUST00000304038.1 Gm2479 (from geneSymbol) uc334rse.1 uc334rse.1 
ENSMUST00000304039.1 ENSMUSG00000131118 ENSMUST00000304039.1 ENSMUSG00000131118 (from geneSymbol) uc334rsf.1 uc334rsf.1 
ENSMUST00000304040.1 ENSMUSG00000131119 ENSMUST00000304040.1 ENSMUSG00000131119 (from geneSymbol) uc334rsg.1 uc334rsg.1 
ENSMUST00000304041.1 ENSMUSG00000131120 ENSMUST00000304041.1 ENSMUSG00000131120 (from geneSymbol) uc334rsh.1 uc334rsh.1 
ENSMUST00000304044.1 ENSMUSG00000131121 ENSMUST00000304044.1 ENSMUSG00000131121 (from geneSymbol) uc334rsk.1 uc334rsk.1 
ENSMUST00000304046.1 Gm33887 ENSMUST00000304046.1 Gm33887 (from geneSymbol) KY467526 uc334rsm.1 uc334rsm.1 
ENSMUST00000304053.1 ENSMUSG00000131122 ENSMUST00000304053.1 ENSMUSG00000131122 (from geneSymbol) uc334rst.1 uc334rst.1 
ENSMUST00000304054.1 ENSMUSG00000131123 ENSMUST00000304054.1 ENSMUSG00000131123 (from geneSymbol) uc334rsu.1 uc334rsu.1 
ENSMUST00000304055.1 ENSMUSG00000131124 ENSMUST00000304055.1 ENSMUSG00000131124 (from geneSymbol) uc334rsv.1 uc334rsv.1 
ENSMUST00000304061.1 ENSMUSG00000131125 ENSMUST00000304061.1 ENSMUSG00000131125 (from geneSymbol) uc334rtb.1 uc334rtb.1 
ENSMUST00000304066.1 ENSMUSG00000131126 ENSMUST00000304066.1 ENSMUSG00000131126 (from geneSymbol) DQ707027 uc334rtg.1 uc334rtg.1 
ENSMUST00000304071.1 ENSMUSG00000131127 ENSMUST00000304071.1 ENSMUSG00000131127 (from geneSymbol) uc334rtl.1 uc334rtl.1 
ENSMUST00000304083.1 ENSMUSG00000131128 ENSMUST00000304083.1 ENSMUSG00000131128 (from geneSymbol) uc334rtx.1 uc334rtx.1 
ENSMUST00000304117.1 ENSMUSG00000131129 ENSMUST00000304117.1 ENSMUSG00000131129 (from geneSymbol) uc334rvf.1 uc334rvf.1 
ENSMUST00000304118.1 ENSMUSG00000131130 ENSMUST00000304118.1 ENSMUSG00000131130 (from geneSymbol) uc334rvg.1 uc334rvg.1 
ENSMUST00000304120.1 ENSMUSG00000131131 ENSMUST00000304120.1 ENSMUSG00000131131 (from geneSymbol) uc334rvi.1 uc334rvi.1 
ENSMUST00000304133.1 ENSMUSG00000131132 ENSMUST00000304133.1 ENSMUSG00000131132 (from geneSymbol) uc334rvv.1 uc334rvv.1 
ENSMUST00000304140.1 ENSMUSG00000131135 ENSMUST00000304140.1 ENSMUSG00000131135 (from geneSymbol) uc334rwb.1 uc334rwb.1 
ENSMUST00000304141.1 ENSMUSG00000131134 ENSMUST00000304141.1 ENSMUSG00000131134 (from geneSymbol) uc334rwc.1 uc334rwc.1 
ENSMUST00000304148.1 B230206L02Rik ENSMUST00000304148.1 B230206L02Rik (from geneSymbol) KY467605 uc334rwj.1 uc334rwj.1 
ENSMUST00000304208.1 ENSMUSG00000131136 ENSMUST00000304208.1 ENSMUSG00000131136 (from geneSymbol) uc334ryr.1 uc334ryr.1 
ENSMUST00000304212.1 ENSMUSG00000131137 ENSMUST00000304212.1 ENSMUSG00000131137 (from geneSymbol) uc334ryv.1 uc334ryv.1 
ENSMUST00000304218.1 Gm57261 ENSMUST00000304218.1 Gm57261 (from geneSymbol) uc334rzb.1 uc334rzb.1 
ENSMUST00000304219.1 Gm2447 ENSMUST00000304219.1 Gm2447 (from geneSymbol) AK087699 uc334rzc.1 uc334rzc.1 
ENSMUST00000304228.1 ENSMUSG00000131138 ENSMUST00000304228.1 ENSMUSG00000131138 (from geneSymbol) uc334rzl.1 uc334rzl.1 
ENSMUST00000304230.1 ENSMUSG00000131139 ENSMUST00000304230.1 ENSMUSG00000131139 (from geneSymbol) uc334rzn.1 uc334rzn.1 
ENSMUST00000304232.1 ENSMUSG00000131140 ENSMUST00000304232.1 ENSMUSG00000131140 (from geneSymbol) uc334rzp.1 uc334rzp.1 
ENSMUST00000304252.1 Gm31818 ENSMUST00000304252.1 Gm31818 (from geneSymbol) uc334saj.1 uc334saj.1 
ENSMUST00000304278.1 ENSMUSG00000131141 ENSMUST00000304278.1 ENSMUSG00000131141 (from geneSymbol) uc334sbj.1 uc334sbj.1 
ENSMUST00000304285.1 ENSMUSG00000131142 ENSMUST00000304285.1 ENSMUSG00000131142 (from geneSymbol) uc334sbq.1 uc334sbq.1 
ENSMUST00000304287.1 ENSMUSG00000131143 ENSMUST00000304287.1 ENSMUSG00000131143 (from geneSymbol) uc334sbs.1 uc334sbs.1 
ENSMUST00000304288.1 ENSMUSG00000131144 ENSMUST00000304288.1 ENSMUSG00000131144 (from geneSymbol) uc334sbt.1 uc334sbt.1 
ENSMUST00000304289.1 ENSMUSG00000131145 ENSMUST00000304289.1 ENSMUSG00000131145 (from geneSymbol) uc334sbu.1 uc334sbu.1 
ENSMUST00000304290.1 ENSMUSG00000131146 ENSMUST00000304290.1 ENSMUSG00000131146 (from geneSymbol) uc334sbv.1 uc334sbv.1 
ENSMUST00000304293.1 ENSMUSG00000131147 ENSMUST00000304293.1 ENSMUSG00000131147 (from geneSymbol) uc334sby.1 uc334sby.1 
ENSMUST00000304295.1 ENSMUSG00000131148 ENSMUST00000304295.1 ENSMUSG00000131148 (from geneSymbol) uc334sca.1 uc334sca.1 
ENSMUST00000304297.1 ENSMUSG00000131149 ENSMUST00000304297.1 ENSMUSG00000131149 (from geneSymbol) uc334scc.1 uc334scc.1 
ENSMUST00000304298.1 ENSMUSG00000131150 ENSMUST00000304298.1 ENSMUSG00000131150 (from geneSymbol) uc334scd.1 uc334scd.1 
ENSMUST00000304300.1 2010308F09Rik ENSMUST00000304300.1 2010308F09Rik (from geneSymbol) AK008545 uc334scf.1 uc334scf.1 
ENSMUST00000304318.1 ENSMUSG00000131151 ENSMUST00000304318.1 ENSMUSG00000131151 (from geneSymbol) uc334scx.1 uc334scx.1 
ENSMUST00000304319.1 ENSMUSG00000131152 ENSMUST00000304319.1 ENSMUSG00000131152 (from geneSymbol) uc334scy.1 uc334scy.1 
ENSMUST00000304321.1 ENSMUSG00000131153 ENSMUST00000304321.1 ENSMUSG00000131153 (from geneSymbol) uc334sda.1 uc334sda.1 
ENSMUST00000304323.1 ENSMUSG00000131154 ENSMUST00000304323.1 ENSMUSG00000131154 (from geneSymbol) uc334sdc.1 uc334sdc.1 
ENSMUST00000304326.1 ENSMUSG00000131155 ENSMUST00000304326.1 ENSMUSG00000131155 (from geneSymbol) uc334sdf.1 uc334sdf.1 
ENSMUST00000304328.1 ENSMUSG00000131156 ENSMUST00000304328.1 ENSMUSG00000131156 (from geneSymbol) uc334sdh.1 uc334sdh.1 
ENSMUST00000304342.1 B930094E09Rik ENSMUST00000304342.1 B930094E09Rik (from geneSymbol) uc334sdi.1 uc334sdi.1 
ENSMUST00000304343.1 ENSMUSG00000131157 ENSMUST00000304343.1 ENSMUSG00000131157 (from geneSymbol) LF204694 uc334sdj.1 uc334sdj.1 
ENSMUST00000304355.1 ENSMUSG00000131158 ENSMUST00000304355.1 ENSMUSG00000131158 (from geneSymbol) uc334sdv.1 uc334sdv.1 
ENSMUST00000304357.1 ENSMUSG00000131159 ENSMUST00000304357.1 ENSMUSG00000131159 (from geneSymbol) uc334sdx.1 uc334sdx.1 
ENSMUST00000304359.1 Gm42875 ENSMUST00000304359.1 Gm42875 (from geneSymbol) AK079143 uc334sdz.1 uc334sdz.1 
ENSMUST00000304360.1 ENSMUSG00000131160 ENSMUST00000304360.1 ENSMUSG00000131160 (from geneSymbol) uc334sea.1 uc334sea.1 
ENSMUST00000304361.1 ENSMUSG00000131161 ENSMUST00000304361.1 ENSMUSG00000131161 (from geneSymbol) uc334seb.1 uc334seb.1 
ENSMUST00000304363.1 ENSMUSG00000131162 ENSMUST00000304363.1 ENSMUSG00000131162 (from geneSymbol) uc334sed.1 uc334sed.1 
ENSMUST00000304365.1 ENSMUSG00000131163 ENSMUST00000304365.1 ENSMUSG00000131163 (from geneSymbol) uc334sef.1 uc334sef.1 
ENSMUST00000304366.1 ENSMUSG00000131164 ENSMUST00000304366.1 ENSMUSG00000131164 (from geneSymbol) uc334seg.1 uc334seg.1 
ENSMUST00000304367.1 ENSMUSG00000131165 ENSMUST00000304367.1 ENSMUSG00000131165 (from geneSymbol) uc334seh.1 uc334seh.1 
ENSMUST00000304375.1 ENSMUSG00000131166 ENSMUST00000304375.1 ENSMUSG00000131166 (from geneSymbol) uc334sep.1 uc334sep.1 
ENSMUST00000304377.1 4931408D14Rik ENSMUST00000304377.1 4931408D14Rik (from geneSymbol) AK040817 uc334ser.1 uc334ser.1 
ENSMUST00000304383.1 ENSMUSG00000131167 ENSMUST00000304383.1 ENSMUSG00000131167 (from geneSymbol) uc334sex.1 uc334sex.1 
ENSMUST00000304385.1 ENSMUSG00000131168 ENSMUST00000304385.1 ENSMUSG00000131168 (from geneSymbol) uc334sez.1 uc334sez.1 
ENSMUST00000304389.1 ENSMUSG00000131170 ENSMUST00000304389.1 ENSMUSG00000131170 (from geneSymbol) uc334sfc.1 uc334sfc.1 
ENSMUST00000304390.1 ENSMUSG00000131171 ENSMUST00000304390.1 ENSMUSG00000131171 (from geneSymbol) uc334sfd.1 uc334sfd.1 
ENSMUST00000304393.1 ENSMUSG00000131172 ENSMUST00000304393.1 ENSMUSG00000131172 (from geneSymbol) uc334sfg.1 uc334sfg.1 
ENSMUST00000304394.1 ENSMUSG00000131173 ENSMUST00000304394.1 ENSMUSG00000131173 (from geneSymbol) uc334sfh.1 uc334sfh.1 
ENSMUST00000304396.1 ENSMUSG00000131174 ENSMUST00000304396.1 ENSMUSG00000131174 (from geneSymbol) uc334sfj.1 uc334sfj.1 
ENSMUST00000304397.1 ENSMUSG00000131175 ENSMUST00000304397.1 ENSMUSG00000131175 (from geneSymbol) uc334sfk.1 uc334sfk.1 
ENSMUST00000304405.1 ENSMUSG00000131176 ENSMUST00000304405.1 ENSMUSG00000131176 (from geneSymbol) uc334sfs.1 uc334sfs.1 
ENSMUST00000304408.1 ENSMUSG00000131177 ENSMUST00000304408.1 ENSMUSG00000131177 (from geneSymbol) uc334sfv.1 uc334sfv.1 
ENSMUST00000304415.1 9430037G07Rik ENSMUST00000304415.1 9430037G07Rik (from geneSymbol) AK034782 uc334sgc.1 uc334sgc.1 
ENSMUST00000304499.1 ENSMUSG00000131178 ENSMUST00000304499.1 ENSMUSG00000131178 (from geneSymbol) uc334sji.1 uc334sji.1 
ENSMUST00000304501.1 Gm28863 ENSMUST00000304501.1 Gm28863 (from geneSymbol) uc334sjj.1 uc334sjj.1 
ENSMUST00000304506.1 ENSMUSG00000131180 ENSMUST00000304506.1 ENSMUSG00000131180 (from geneSymbol) uc334sjo.1 uc334sjo.1 
ENSMUST00000304564.1 ENSMUSG00000131181 ENSMUST00000304564.1 ENSMUSG00000131181 (from geneSymbol) uc334slu.1 uc334slu.1 
ENSMUST00000304567.1 Gm14051 ENSMUST00000304567.1 Gm14051 (from geneSymbol) uc334slx.1 uc334slx.1 
ENSMUST00000304614.1 ENSMUSG00000131182 ENSMUST00000304614.1 ENSMUSG00000131182 (from geneSymbol) uc334sns.1 uc334sns.1 
ENSMUST00000304616.1 ENSMUSG00000131183 ENSMUST00000304616.1 ENSMUSG00000131183 (from geneSymbol) AK147279 uc334snu.1 uc334snu.1 
ENSMUST00000304617.1 ENSMUSG00000131184 ENSMUST00000304617.1 ENSMUSG00000131184 (from geneSymbol) uc334snv.1 uc334snv.1 
ENSMUST00000304619.1 ENSMUSG00000131185 ENSMUST00000304619.1 ENSMUSG00000131185 (from geneSymbol) uc334snx.1 uc334snx.1 
ENSMUST00000304621.1 ENSMUSG00000131187 ENSMUST00000304621.1 ENSMUSG00000131187 (from geneSymbol) uc334sny.1 uc334sny.1 
ENSMUST00000304625.1 ENSMUSG00000131188 ENSMUST00000304625.1 ENSMUSG00000131188 (from geneSymbol) uc334soc.1 uc334soc.1 
ENSMUST00000304627.1 ENSMUSG00000131189 ENSMUST00000304627.1 ENSMUSG00000131189 (from geneSymbol) uc334soe.1 uc334soe.1 
ENSMUST00000304629.1 ENSMUSG00000131190 ENSMUST00000304629.1 ENSMUSG00000131190 (from geneSymbol) uc334sog.1 uc334sog.1 
ENSMUST00000304637.1 ENSMUSG00000121897 ENSMUST00000304637.1 ENSMUSG00000121897 (from geneSymbol) BC040090 uc334soo.1 uc334soo.1 
ENSMUST00000304639.1 ENSMUSG00000131191 ENSMUST00000304639.1 ENSMUSG00000131191 (from geneSymbol) uc334soq.1 uc334soq.1 
ENSMUST00000304641.1 ENSMUSG00000131192 ENSMUST00000304641.1 ENSMUSG00000131192 (from geneSymbol) uc334sos.1 uc334sos.1 
ENSMUST00000304643.1 ENSMUSG00000131193 ENSMUST00000304643.1 ENSMUSG00000131193 (from geneSymbol) uc334sou.1 uc334sou.1 
ENSMUST00000304644.1 ENSMUSG00000131194 ENSMUST00000304644.1 ENSMUSG00000131194 (from geneSymbol) uc334sov.1 uc334sov.1 
ENSMUST00000304646.1 ENSMUSG00000131195 ENSMUST00000304646.1 ENSMUSG00000131195 (from geneSymbol) AK076880 uc334sox.1 uc334sox.1 
ENSMUST00000304647.1 ENSMUSG00000131196 ENSMUST00000304647.1 ENSMUSG00000131196 (from geneSymbol) uc334soy.1 uc334soy.1 
ENSMUST00000304649.1 Gm49756 ENSMUST00000304649.1 Gm49756 (from geneSymbol) uc334spa.1 uc334spa.1 
ENSMUST00000304667.1 ENSMUSG00000131197 ENSMUST00000304667.1 ENSMUSG00000131197 (from geneSymbol) uc334sps.1 uc334sps.1 
ENSMUST00000304672.1 ENSMUSG00000131198 ENSMUST00000304672.1 ENSMUSG00000131198 (from geneSymbol) uc334spx.1 uc334spx.1 
ENSMUST00000304674.1 ENSMUSG00000131199 ENSMUST00000304674.1 ENSMUSG00000131199 (from geneSymbol) uc334spz.1 uc334spz.1 
ENSMUST00000304675.1 ENSMUSG00000131200 ENSMUST00000304675.1 ENSMUSG00000131200 (from geneSymbol) uc334sqa.1 uc334sqa.1 
ENSMUST00000304677.1 ENSMUSG00000131201 ENSMUST00000304677.1 predicted gene 10910 (from RefSeq NR_165839.1) NR_165839 uc334sqc.1 uc334sqc.1 
ENSMUST00000304679.1 ENSMUSG00000131202 ENSMUST00000304679.1 ENSMUSG00000131202 (from geneSymbol) uc334sqe.1 uc334sqe.1 
ENSMUST00000304703.1 4930503O07Rik ENSMUST00000304703.1 4930503O07Rik (from geneSymbol) uc334src.1 uc334src.1 
ENSMUST00000304742.1 Gm16146 ENSMUST00000304742.1 Gm16146 (from geneSymbol) uc334ssp.1 uc334ssp.1 
ENSMUST00000304744.1 ENSMUSG00000131203 ENSMUST00000304744.1 ENSMUSG00000131203 (from geneSymbol) uc334ssr.1 uc334ssr.1 
ENSMUST00000304748.1 ENSMUSG00000131204 ENSMUST00000304748.1 ENSMUSG00000131204 (from geneSymbol) uc334ssv.1 uc334ssv.1 
ENSMUST00000304752.1 BC043934 ENSMUST00000304752.1 BC043934 (from geneSymbol) uc334ssz.1 uc334ssz.1 
ENSMUST00000304754.1 Gm32585 ENSMUST00000304754.1 Gm32585 (from geneSymbol) uc334sta.1 uc334sta.1 
ENSMUST00000304780.1 ENSMUSG00000131205 ENSMUST00000304780.1 ENSMUSG00000131205 (from geneSymbol) uc334sua.1 uc334sua.1 
ENSMUST00000304781.1 ENSMUSG00000131206 ENSMUST00000304781.1 ENSMUSG00000131206 (from geneSymbol) uc334sub.1 uc334sub.1 
ENSMUST00000304786.1 ENSMUSG00000131207 ENSMUST00000304786.1 ENSMUSG00000131207 (from geneSymbol) uc334sug.1 uc334sug.1 
ENSMUST00000304789.1 ENSMUSG00000131208 ENSMUST00000304789.1 ENSMUSG00000131208 (from geneSymbol) uc334suj.1 uc334suj.1 
ENSMUST00000304801.1 ENSMUSG00000131209 ENSMUST00000304801.1 ENSMUSG00000131209 (from geneSymbol) AK044542 uc334suv.1 uc334suv.1 
ENSMUST00000304802.1 ENSMUSG00000131210 ENSMUST00000304802.1 ENSMUSG00000131210 (from geneSymbol) uc334suw.1 uc334suw.1 
ENSMUST00000304803.1 4933408A14Rik ENSMUST00000304803.1 4933408A14Rik (from geneSymbol) AK016734 uc334sux.1 uc334sux.1 
ENSMUST00000304805.1 ENSMUSG00000131212 ENSMUST00000304805.1 ENSMUSG00000131212 (from geneSymbol) uc334suy.1 uc334suy.1 
ENSMUST00000304806.1 ENSMUSG00000131213 ENSMUST00000304806.1 ENSMUSG00000131213 (from geneSymbol) uc334suz.1 uc334suz.1 
ENSMUST00000304807.1 ENSMUSG00000131214 ENSMUST00000304807.1 ENSMUSG00000131214 (from geneSymbol) uc334sva.1 uc334sva.1 
ENSMUST00000304808.1 ENSMUSG00000131215 ENSMUST00000304808.1 ENSMUSG00000131215 (from geneSymbol) uc334svb.1 uc334svb.1 
ENSMUST00000304810.1 ENSMUSG00000131216 ENSMUST00000304810.1 ENSMUSG00000131216 (from geneSymbol) uc334svd.1 uc334svd.1 
ENSMUST00000304815.1 4930425L21Rik ENSMUST00000304815.1 4930425L21Rik (from geneSymbol) uc334svi.1 uc334svi.1 
ENSMUST00000304831.1 Gm6566 ENSMUST00000304831.1 Gm6566 (from geneSymbol) BC042778 uc334svy.1 uc334svy.1 
ENSMUST00000304834.1 ENSMUSG00000131217 ENSMUST00000304834.1 ENSMUSG00000131217 (from geneSymbol) AK158492 uc334swb.1 uc334swb.1 
ENSMUST00000304836.1 ENSMUSG00000131218 ENSMUST00000304836.1 ENSMUSG00000131218 (from geneSymbol) uc334swd.1 uc334swd.1 
ENSMUST00000304838.1 ENSMUSG00000131219 ENSMUST00000304838.1 ENSMUSG00000131219 (from geneSymbol) uc334swf.1 uc334swf.1 
ENSMUST00000304841.1 2900089D17Rik ENSMUST00000304841.1 RIKEN cDNA 2900089D17 gene, transcript variant 3 (from RefSeq NR_190065.1) NR_190065 uc334swi.1 uc334swi.1 
ENSMUST00000304844.1 ENSMUSG00000131220 ENSMUST00000304844.1 ENSMUSG00000131220 (from geneSymbol) uc334swl.1 uc334swl.1 
ENSMUST00000304845.1 ENSMUSG00000131221 ENSMUST00000304845.1 ENSMUSG00000131221 (from geneSymbol) uc334swm.1 uc334swm.1 
ENSMUST00000304846.1 ENSMUSG00000131222 ENSMUST00000304846.1 ENSMUSG00000131222 (from geneSymbol) uc334swn.1 uc334swn.1 
ENSMUST00000304847.1 ENSMUSG00000131223 ENSMUST00000304847.1 ENSMUSG00000131223 (from geneSymbol) LF198096 uc334swo.1 uc334swo.1 
ENSMUST00000304848.1 ENSMUSG00000131224 ENSMUST00000304848.1 ENSMUSG00000131224 (from geneSymbol) uc334swp.1 uc334swp.1 
ENSMUST00000304849.1 ENSMUSG00000131225 ENSMUST00000304849.1 ENSMUSG00000131225 (from geneSymbol) uc334swq.1 uc334swq.1 
ENSMUST00000304851.1 ENSMUSG00000131226 ENSMUST00000304851.1 ENSMUSG00000131226 (from geneSymbol) uc334sws.1 uc334sws.1 
ENSMUST00000304852.1 ENSMUSG00000131227 ENSMUST00000304852.1 ENSMUSG00000131227 (from geneSymbol) uc334swt.1 uc334swt.1 
ENSMUST00000304853.1 ENSMUSG00000131228 ENSMUST00000304853.1 ENSMUSG00000131228 (from geneSymbol) uc334swu.1 uc334swu.1 
ENSMUST00000304855.1 Gm40323 ENSMUST00000304855.1 Gm40323 (from geneSymbol) uc334sww.1 uc334sww.1 
ENSMUST00000304858.1 ENSMUSG00000131230 ENSMUST00000304858.1 ENSMUSG00000131230 (from geneSymbol) uc334swy.1 uc334swy.1 
ENSMUST00000304859.1 ENSMUSG00000131231 ENSMUST00000304859.1 ENSMUSG00000131231 (from geneSymbol) uc334swz.1 uc334swz.1 
ENSMUST00000304860.1 ENSMUSG00000131232 ENSMUST00000304860.1 ENSMUSG00000131232 (from geneSymbol) uc334sxa.1 uc334sxa.1 
ENSMUST00000304861.1 ENSMUSG00000131233 ENSMUST00000304861.1 ENSMUSG00000131233 (from geneSymbol) uc334sxb.1 uc334sxb.1 
ENSMUST00000304862.1 ENSMUSG00000131234 ENSMUST00000304862.1 ENSMUSG00000131234 (from geneSymbol) uc334sxc.1 uc334sxc.1 
ENSMUST00000304865.1 ENSMUSG00000131235 ENSMUST00000304865.1 ENSMUSG00000131235 (from geneSymbol) uc334sxf.1 uc334sxf.1 
ENSMUST00000304866.1 ENSMUSG00000131236 ENSMUST00000304866.1 ENSMUSG00000131236 (from geneSymbol) uc334sxg.1 uc334sxg.1 
ENSMUST00000304867.1 ENSMUSG00000131237 ENSMUST00000304867.1 ENSMUSG00000131237 (from geneSymbol) uc334sxh.1 uc334sxh.1 
ENSMUST00000304869.1 ENSMUSG00000131239 ENSMUST00000304869.1 ENSMUSG00000131239 (from geneSymbol) uc334sxi.1 uc334sxi.1 
ENSMUST00000304870.1 ENSMUSG00000131240 ENSMUST00000304870.1 ENSMUSG00000131240 (from geneSymbol) uc334sxj.1 uc334sxj.1 
ENSMUST00000304871.1 ENSMUSG00000131241 ENSMUST00000304871.1 ENSMUSG00000131241 (from geneSymbol) uc334sxk.1 uc334sxk.1 
ENSMUST00000304872.1 ENSMUSG00000131242 ENSMUST00000304872.1 ENSMUSG00000131242 (from geneSymbol) uc334sxl.1 uc334sxl.1 
ENSMUST00000304873.1 ENSMUSG00000131243 ENSMUST00000304873.1 ENSMUSG00000131243 (from geneSymbol) AK142614 uc334sxm.1 uc334sxm.1 
ENSMUST00000304876.1 ENSMUSG00000131244 ENSMUST00000304876.1 ENSMUSG00000131244 (from geneSymbol) uc334sxp.1 uc334sxp.1 
ENSMUST00000304881.1 4930487D11Rik ENSMUST00000304881.1 4930487D11Rik (from geneSymbol) AK019659 uc334sxt.1 uc334sxt.1 
ENSMUST00000304891.1 ENSMUSG00000131245 ENSMUST00000304891.1 ENSMUSG00000131245 (from geneSymbol) uc334syd.1 uc334syd.1 
ENSMUST00000304892.1 ENSMUSG00000131246 ENSMUST00000304892.1 ENSMUSG00000131246 (from geneSymbol) uc334sye.1 uc334sye.1 
ENSMUST00000304893.1 ENSMUSG00000131247 ENSMUST00000304893.1 ENSMUSG00000131247 (from geneSymbol) uc334syf.1 uc334syf.1 
ENSMUST00000304897.1 ENSMUSG00000131248 ENSMUST00000304897.1 ENSMUSG00000131248 (from geneSymbol) uc334syj.1 uc334syj.1 
ENSMUST00000304899.1 ENSMUSG00000131249 ENSMUST00000304899.1 ENSMUSG00000131249 (from geneSymbol) AK016233 uc334syl.1 uc334syl.1 
ENSMUST00000304900.1 ENSMUSG00000131250 ENSMUST00000304900.1 ENSMUSG00000131250 (from geneSymbol) uc334sym.1 uc334sym.1 
ENSMUST00000304901.1 ENSMUSG00000131251 ENSMUST00000304901.1 ENSMUSG00000131251 (from geneSymbol) uc334syn.1 uc334syn.1 
ENSMUST00000304913.1 ENSMUSG00000131252 ENSMUST00000304913.1 ENSMUSG00000131252 (from geneSymbol) uc334syz.1 uc334syz.1 
ENSMUST00000304915.1 ENSMUSG00000131253 ENSMUST00000304915.1 ENSMUSG00000131253 (from geneSymbol) uc334szb.1 uc334szb.1 
ENSMUST00000304924.1 ENSMUSG00000131254 ENSMUST00000304924.1 ENSMUSG00000131254 (from geneSymbol) uc334szk.1 uc334szk.1 
ENSMUST00000304926.1 ENSMUSG00000131255 ENSMUST00000304926.1 ENSMUSG00000131255 (from geneSymbol) uc334szm.1 uc334szm.1 
ENSMUST00000304928.1 Gm56796 ENSMUST00000304928.1 Gm56796 (from geneSymbol) uc334szo.1 uc334szo.1 
ENSMUST00000304930.1 Gm56654 ENSMUST00000304930.1 Gm56654 (from geneSymbol) uc334szq.1 uc334szq.1 
ENSMUST00000304933.1 ENSMUSG00000131257 ENSMUST00000304933.1 ENSMUSG00000131257 (from geneSymbol) uc334szt.1 uc334szt.1 
ENSMUST00000304936.1 ENSMUSG00000131258 ENSMUST00000304936.1 ENSMUSG00000131258 (from geneSymbol) uc334szw.1 uc334szw.1 
ENSMUST00000304937.1 ENSMUSG00000131259 ENSMUST00000304937.1 ENSMUSG00000131259 (from geneSymbol) uc334szx.1 uc334szx.1 
ENSMUST00000304939.1 ENSMUSG00000131260 ENSMUST00000304939.1 ENSMUSG00000131260 (from geneSymbol) uc334szz.1 uc334szz.1 
ENSMUST00000304942.1 Gm32151 ENSMUST00000304942.1 Gm32151 (from geneSymbol) uc334tac.1 uc334tac.1 
ENSMUST00000304963.1 ENSMUSG00000131261 ENSMUST00000304963.1 ENSMUSG00000131261 (from geneSymbol) uc334tax.1 uc334tax.1 
ENSMUST00000304965.1 ENSMUSG00000131262 ENSMUST00000304965.1 ENSMUSG00000131262 (from geneSymbol) uc334taz.1 uc334taz.1 
ENSMUST00000304966.1 ENSMUSG00000131263 ENSMUST00000304966.1 ENSMUSG00000131263 (from geneSymbol) uc334tba.1 uc334tba.1 
ENSMUST00000304981.1 ENSMUSG00000131264 ENSMUST00000304981.1 ENSMUSG00000131264 (from geneSymbol) AK017099 uc334tbp.1 uc334tbp.1 
ENSMUST00000304983.1 ENSMUSG00000131265 ENSMUST00000304983.1 ENSMUSG00000131265 (from geneSymbol) uc334tbr.1 uc334tbr.1 
ENSMUST00000304984.1 ENSMUSG00000131266 ENSMUST00000304984.1 ENSMUSG00000131266 (from geneSymbol) uc334tbs.1 uc334tbs.1 
ENSMUST00000304985.1 ENSMUSG00000131267 ENSMUST00000304985.1 ENSMUSG00000131267 (from geneSymbol) uc334tbt.1 uc334tbt.1 
ENSMUST00000304989.1 ENSMUSG00000131268 ENSMUST00000304989.1 ENSMUSG00000131268 (from geneSymbol) uc334tbx.1 uc334tbx.1 
ENSMUST00000304990.1 ENSMUSG00000131269 ENSMUST00000304990.1 ENSMUSG00000131269 (from geneSymbol) uc334tby.1 uc334tby.1 
ENSMUST00000304992.1 ENSMUSG00000131270 ENSMUST00000304992.1 ENSMUSG00000131270 (from geneSymbol) uc334tca.1 uc334tca.1 
ENSMUST00000304993.1 ENSMUSG00000131271 ENSMUST00000304993.1 ENSMUSG00000131271 (from geneSymbol) uc334tcb.1 uc334tcb.1 
ENSMUST00000304996.1 ENSMUSG00000131272 ENSMUST00000304996.1 ENSMUSG00000131272 (from geneSymbol) uc334tce.1 uc334tce.1 
ENSMUST00000304998.1 ENSMUSG00000131273 ENSMUST00000304998.1 ENSMUSG00000131273 (from geneSymbol) uc334tcg.1 uc334tcg.1 
ENSMUST00000304999.1 ENSMUSG00000131274 ENSMUST00000304999.1 ENSMUSG00000131274 (from geneSymbol) uc334tch.1 uc334tch.1 
ENSMUST00000305000.1 ENSMUSG00000131275 ENSMUST00000305000.1 ENSMUSG00000131275 (from geneSymbol) uc334tci.1 uc334tci.1 
ENSMUST00000305002.1 ENSMUSG00000131276 ENSMUST00000305002.1 ENSMUSG00000131276 (from geneSymbol) uc334tck.1 uc334tck.1 
ENSMUST00000305003.1 ENSMUSG00000131277 ENSMUST00000305003.1 ENSMUSG00000131277 (from geneSymbol) uc334tcl.1 uc334tcl.1 
ENSMUST00000305004.1 ENSMUSG00000131278 ENSMUST00000305004.1 ENSMUSG00000131278 (from geneSymbol) uc334tcm.1 uc334tcm.1 
ENSMUST00000305005.1 ENSMUSG00000131279 ENSMUST00000305005.1 ENSMUSG00000131279 (from geneSymbol) uc334tcn.1 uc334tcn.1 
ENSMUST00000305006.1 Gm26560 ENSMUST00000305006.1 Gm26560 (from geneSymbol) AK044390 uc334tco.1 uc334tco.1 
ENSMUST00000305031.1 ENSMUSG00000131280 ENSMUST00000305031.1 ENSMUSG00000131280 (from geneSymbol) uc334tdn.1 uc334tdn.1 
ENSMUST00000305034.1 1700013N06Rik ENSMUST00000305034.1 1700013N06Rik (from geneSymbol) AK005966 uc334tdq.1 uc334tdq.1 
ENSMUST00000305046.1 Gm57152 ENSMUST00000305046.1 Gm57152 (from geneSymbol) uc334tec.1 uc334tec.1 
ENSMUST00000305049.1 ENSMUSG00000131281 ENSMUST00000305049.1 ENSMUSG00000131281 (from geneSymbol) uc334tef.1 uc334tef.1 
ENSMUST00000305054.1 ENSMUSG00000131282 ENSMUST00000305054.1 ENSMUSG00000131282 (from geneSymbol) uc334tek.1 uc334tek.1 
ENSMUST00000305056.1 ENSMUSG00000131283 ENSMUST00000305056.1 ENSMUSG00000131283 (from geneSymbol) uc334tem.1 uc334tem.1 
ENSMUST00000305059.1 ENSMUSG00000131284 ENSMUST00000305059.1 ENSMUSG00000131284 (from geneSymbol) uc334tep.1 uc334tep.1 
ENSMUST00000305062.1 ENSMUSG00000131285 ENSMUST00000305062.1 ENSMUSG00000131285 (from geneSymbol) uc334tes.1 uc334tes.1 
ENSMUST00000305064.1 ENSMUSG00000131286 ENSMUST00000305064.1 ENSMUSG00000131286 (from geneSymbol) uc334teu.1 uc334teu.1 
ENSMUST00000305065.1 ENSMUSG00000131287 ENSMUST00000305065.1 ENSMUSG00000131287 (from geneSymbol) uc334tev.1 uc334tev.1 
ENSMUST00000305076.1 Gm31727 ENSMUST00000305076.1 Gm31727 (from geneSymbol) uc334tfg.1 uc334tfg.1 
ENSMUST00000305080.1 ENSMUSG00000131288 ENSMUST00000305080.1 ENSMUSG00000131288 (from geneSymbol) uc334tfk.1 uc334tfk.1 
ENSMUST00000305085.1 ENSMUSG00000131289 ENSMUST00000305085.1 ENSMUSG00000131289 (from geneSymbol) uc334tfl.1 uc334tfl.1 
ENSMUST00000305087.1 ENSMUSG00000131290 ENSMUST00000305087.1 ENSMUSG00000131290 (from geneSymbol) uc334tfn.1 uc334tfn.1 
ENSMUST00000305088.1 ENSMUSG00000131291 ENSMUST00000305088.1 ENSMUSG00000131291 (from geneSymbol) uc334tfo.1 uc334tfo.1 
ENSMUST00000305089.1 ENSMUSG00000131292 ENSMUST00000305089.1 ENSMUSG00000131292 (from geneSymbol) uc334tfp.1 uc334tfp.1 
ENSMUST00000305100.1 ENSMUSG00000131293 ENSMUST00000305100.1 ENSMUSG00000131293 (from geneSymbol) uc334tga.1 uc334tga.1 
ENSMUST00000305101.1 ENSMUSG00000131294 ENSMUST00000305101.1 ENSMUSG00000131294 (from geneSymbol) uc334tgb.1 uc334tgb.1 
ENSMUST00000305102.1 ENSMUSG00000131295 ENSMUST00000305102.1 ENSMUSG00000131295 (from geneSymbol) uc334tgc.1 uc334tgc.1 
ENSMUST00000305103.1 ENSMUSG00000131296 ENSMUST00000305103.1 ENSMUSG00000131296 (from geneSymbol) uc334tgd.1 uc334tgd.1 
ENSMUST00000305104.1 ENSMUSG00000131297 ENSMUST00000305104.1 ENSMUSG00000131297 (from geneSymbol) uc334tge.1 uc334tge.1 
ENSMUST00000305105.1 ENSMUSG00000131298 ENSMUST00000305105.1 ENSMUSG00000131298 (from geneSymbol) uc334tgf.1 uc334tgf.1 
ENSMUST00000305106.1 ENSMUSG00000131299 ENSMUST00000305106.1 ENSMUSG00000131299 (from geneSymbol) AK170567 uc334tgg.1 uc334tgg.1 
ENSMUST00000305107.1 ENSMUSG00000131300 ENSMUST00000305107.1 ENSMUSG00000131300 (from geneSymbol) uc334tgh.1 uc334tgh.1 
ENSMUST00000305108.1 ENSMUSG00000131301 ENSMUST00000305108.1 ENSMUSG00000131301 (from geneSymbol) uc334tgi.1 uc334tgi.1 
ENSMUST00000305110.1 ENSMUSG00000131302 ENSMUST00000305110.1 ENSMUSG00000131302 (from geneSymbol) uc334tgk.1 uc334tgk.1 
ENSMUST00000305111.1 ENSMUSG00000131303 ENSMUST00000305111.1 ENSMUSG00000131303 (from geneSymbol) uc334tgl.1 uc334tgl.1 
ENSMUST00000305112.1 ENSMUSG00000131304 ENSMUST00000305112.1 ENSMUSG00000131304 (from geneSymbol) uc334tgm.1 uc334tgm.1 
ENSMUST00000305113.1 Gm56982 ENSMUST00000305113.1 Gm56982 (from geneSymbol) uc334tgn.1 uc334tgn.1 
ENSMUST00000305115.1 ENSMUSG00000131305 ENSMUST00000305115.1 ENSMUSG00000131305 (from geneSymbol) uc334tgp.1 uc334tgp.1 
ENSMUST00000305116.1 ENSMUSG00000131306 ENSMUST00000305116.1 ENSMUSG00000131306 (from geneSymbol) uc334tgq.1 uc334tgq.1 
ENSMUST00000305120.1 ENSMUSG00000131307 ENSMUST00000305120.1 ENSMUSG00000131307 (from geneSymbol) uc334tgu.1 uc334tgu.1 
ENSMUST00000305121.1 ENSMUSG00000131308 ENSMUST00000305121.1 ENSMUSG00000131308 (from geneSymbol) uc334tgv.1 uc334tgv.1 
ENSMUST00000305123.1 ENSMUSG00000131309 ENSMUST00000305123.1 ENSMUSG00000131309 (from geneSymbol) uc334tgx.1 uc334tgx.1 
ENSMUST00000305125.1 ENSMUSG00000131310 ENSMUST00000305125.1 ENSMUSG00000131310 (from geneSymbol) uc334tgz.1 uc334tgz.1 
ENSMUST00000305126.1 ENSMUSG00000131311 ENSMUST00000305126.1 ENSMUSG00000131311 (from geneSymbol) uc334tha.1 uc334tha.1 
ENSMUST00000305127.1 ENSMUSG00000131312 ENSMUST00000305127.1 ENSMUSG00000131312 (from geneSymbol) uc334thb.1 uc334thb.1 
ENSMUST00000305131.1 ENSMUSG00000131313 ENSMUST00000305131.1 ENSMUSG00000131313 (from geneSymbol) uc334thf.1 uc334thf.1 
ENSMUST00000305132.1 ENSMUSG00000131314 ENSMUST00000305132.1 ENSMUSG00000131314 (from geneSymbol) uc334thg.1 uc334thg.1 
ENSMUST00000305134.1 ENSMUSG00000131315 ENSMUST00000305134.1 ENSMUSG00000131315 (from geneSymbol) uc334thi.1 uc334thi.1 
ENSMUST00000305141.1 ENSMUSG00000131316 ENSMUST00000305141.1 ENSMUSG00000131316 (from geneSymbol) uc334thp.1 uc334thp.1 
ENSMUST00000305154.1 ENSMUSG00000131317 ENSMUST00000305154.1 ENSMUSG00000131317 (from geneSymbol) uc334tic.1 uc334tic.1 
ENSMUST00000305167.1 4930452A19Rik ENSMUST00000305167.1 4930452A19Rik (from geneSymbol) AK019626 uc334tip.1 uc334tip.1 
ENSMUST00000305193.1 4930444A19Rik ENSMUST00000305193.1 4930444A19Rik (from geneSymbol) AK139166 uc334tjp.1 uc334tjp.1 
ENSMUST00000305204.1 ENSMUSG00000131318 ENSMUST00000305204.1 ENSMUSG00000131318 (from geneSymbol) uc334tka.1 uc334tka.1 
ENSMUST00000305205.1 ENSMUSG00000131319 ENSMUST00000305205.1 ENSMUSG00000131319 (from geneSymbol) uc334tkb.1 uc334tkb.1 
ENSMUST00000305207.1 ENSMUSG00000131320 ENSMUST00000305207.1 ENSMUSG00000131320 (from geneSymbol) uc334tkd.1 uc334tkd.1 
ENSMUST00000305209.1 ENSMUSG00000131321 ENSMUST00000305209.1 ENSMUSG00000131321 (from geneSymbol) uc334tkf.1 uc334tkf.1 
ENSMUST00000305214.1 ENSMUSG00000131322 ENSMUST00000305214.1 ENSMUSG00000131322 (from geneSymbol) uc334tkk.1 uc334tkk.1 
ENSMUST00000305215.1 ENSMUSG00000131323 ENSMUST00000305215.1 ENSMUSG00000131323 (from geneSymbol) uc334tkl.1 uc334tkl.1 
ENSMUST00000305216.1 ENSMUSG00000131324 ENSMUST00000305216.1 ENSMUSG00000131324 (from geneSymbol) uc334tkm.1 uc334tkm.1 
ENSMUST00000305217.1 ENSMUSG00000131325 ENSMUST00000305217.1 ENSMUSG00000131325 (from geneSymbol) uc334tkn.1 uc334tkn.1 
ENSMUST00000305218.1 ENSMUSG00000131326 ENSMUST00000305218.1 ENSMUSG00000131326 (from geneSymbol) uc334tko.1 uc334tko.1 
ENSMUST00000305220.1 ENSMUSG00000131327 ENSMUST00000305220.1 ENSMUSG00000131327 (from geneSymbol) uc334tkq.1 uc334tkq.1 
ENSMUST00000305226.1 ENSMUSG00000131329 ENSMUST00000305226.1 ENSMUSG00000131329 (from geneSymbol) uc334tkw.1 uc334tkw.1 
ENSMUST00000305228.1 ENSMUSG00000131328 ENSMUST00000305228.1 ENSMUSG00000131328 (from geneSymbol) uc334tky.1 uc334tky.1 
ENSMUST00000305255.1 ENSMUSG00000131330 ENSMUST00000305255.1 ENSMUSG00000131330 (from geneSymbol) uc334tlz.1 uc334tlz.1 
ENSMUST00000305264.1 ENSMUSG00000131331 ENSMUST00000305264.1 ENSMUSG00000131331 (from geneSymbol) uc334tmi.1 uc334tmi.1 
ENSMUST00000305278.1 ENSMUSG00000131332 ENSMUST00000305278.1 ENSMUSG00000131332 (from geneSymbol) uc334tmw.1 uc334tmw.1 
ENSMUST00000305279.1 ENSMUSG00000131333 ENSMUST00000305279.1 ENSMUSG00000131333 (from geneSymbol) uc334tmx.1 uc334tmx.1 
ENSMUST00000305280.1 Gm34719 ENSMUST00000305280.1 Gm34719 (from geneSymbol) uc334tmy.1 uc334tmy.1 
ENSMUST00000305336.1 ENSMUSG00000131334 ENSMUST00000305336.1 ENSMUSG00000131334 (from geneSymbol) uc334tpc.1 uc334tpc.1 
ENSMUST00000305342.1 ENSMUSG00000131335 ENSMUST00000305342.1 ENSMUSG00000131335 (from geneSymbol) uc334tpi.1 uc334tpi.1 
ENSMUST00000305343.1 ENSMUSG00000131336 ENSMUST00000305343.1 ENSMUSG00000131336 (from geneSymbol) uc334tpj.1 uc334tpj.1 
ENSMUST00000305347.1 ENSMUSG00000131337 ENSMUST00000305347.1 ENSMUSG00000131337 (from geneSymbol) LF202684 uc334tpn.1 uc334tpn.1 
ENSMUST00000305348.1 ENSMUSG00000131338 ENSMUST00000305348.1 ENSMUSG00000131338 (from geneSymbol) uc334tpo.1 uc334tpo.1 
ENSMUST00000305351.1 ENSMUSG00000131339 ENSMUST00000305351.1 ENSMUSG00000131339 (from geneSymbol) uc334tpr.1 uc334tpr.1 
ENSMUST00000305369.1 ENSMUSG00000131340 ENSMUST00000305369.1 ENSMUSG00000131340 (from geneSymbol) uc334tqj.1 uc334tqj.1 
ENSMUST00000305371.1 ENSMUSG00000131341 ENSMUST00000305371.1 ENSMUSG00000131341 (from geneSymbol) uc334tql.1 uc334tql.1 
ENSMUST00000305377.1 ENSMUSG00000131342 ENSMUST00000305377.1 ENSMUSG00000131342 (from geneSymbol) uc334tqr.1 uc334tqr.1 
ENSMUST00000305378.1 Gm47863 ENSMUST00000305378.1 Gm47863 (from geneSymbol) uc334tqs.1 uc334tqs.1 
ENSMUST00000305379.1 ENSMUSG00000131343 ENSMUST00000305379.1 ENSMUSG00000131343 (from geneSymbol) uc334tqt.1 uc334tqt.1 
ENSMUST00000305384.1 2610028E06Rik ENSMUST00000305384.1 2610028E06Rik (from geneSymbol) AK083757 uc334tqy.1 uc334tqy.1 
ENSMUST00000305421.1 ENSMUSG00000131344 ENSMUST00000305421.1 ENSMUSG00000131344 (from geneSymbol) uc334tsj.1 uc334tsj.1 
ENSMUST00000305423.1 Gm57334 ENSMUST00000305423.1 Gm57334 (from geneSymbol) uc334tsl.1 uc334tsl.1 
ENSMUST00000305425.1 ENSMUSG00000131345 ENSMUST00000305425.1 ENSMUSG00000131345 (from geneSymbol) uc334tsn.1 uc334tsn.1 
ENSMUST00000305426.1 Gm14742 ENSMUST00000305426.1 Gm14742 (from geneSymbol) uc334tso.1 uc334tso.1 
ENSMUST00000305427.1 ENSMUSG00000131346 ENSMUST00000305427.1 ENSMUSG00000131346 (from geneSymbol) uc334tsp.1 uc334tsp.1 
ENSMUST00000305428.1 ENSMUSG00000131347 ENSMUST00000305428.1 ENSMUSG00000131347 (from geneSymbol) uc334tsq.1 uc334tsq.1 
ENSMUST00000305430.1 ENSMUSG00000131348 ENSMUST00000305430.1 ENSMUSG00000131348 (from geneSymbol) LF247241 uc334tss.1 uc334tss.1 
ENSMUST00000305431.1 Gm28706 ENSMUST00000305431.1 Gm28706 (from geneSymbol) uc334tst.1 uc334tst.1 
ENSMUST00000305434.1 ENSMUSG00000131349 ENSMUST00000305434.1 ENSMUSG00000131349 (from geneSymbol) uc334tsw.1 uc334tsw.1 
ENSMUST00000305435.1 ENSMUSG00000131350 ENSMUST00000305435.1 ENSMUSG00000131350 (from geneSymbol) uc334tsx.1 uc334tsx.1 
ENSMUST00000305436.1 ENSMUSG00000131351 ENSMUST00000305436.1 ENSMUSG00000131351 (from geneSymbol) uc334tsy.1 uc334tsy.1 
ENSMUST00000305437.1 ENSMUSG00000131352 ENSMUST00000305437.1 ENSMUSG00000131352 (from geneSymbol) uc334tsz.1 uc334tsz.1 
ENSMUST00000305439.1 ENSMUSG00000131353 ENSMUST00000305439.1 ENSMUSG00000131353 (from geneSymbol) uc334ttb.1 uc334ttb.1 
ENSMUST00000305440.1 ENSMUSG00000131354 ENSMUST00000305440.1 ENSMUSG00000131354 (from geneSymbol) uc334ttc.1 uc334ttc.1 
ENSMUST00000305441.1 ENSMUSG00000131355 ENSMUST00000305441.1 ENSMUSG00000131355 (from geneSymbol) uc334ttd.1 uc334ttd.1 
ENSMUST00000305443.1 ENSMUSG00000131356 ENSMUST00000305443.1 ENSMUSG00000131356 (from geneSymbol) uc334ttf.1 uc334ttf.1 
ENSMUST00000305484.1 ENSMUSG00000131357 ENSMUST00000305484.1 ENSMUSG00000131357 (from geneSymbol) uc334tut.1 uc334tut.1 
ENSMUST00000305485.1 ENSMUSG00000131358 ENSMUST00000305485.1 ENSMUSG00000131358 (from geneSymbol) uc334tuu.1 uc334tuu.1 
ENSMUST00000305490.1 ENSMUSG00000131359 ENSMUST00000305490.1 ENSMUSG00000131359 (from geneSymbol) uc334tuz.1 uc334tuz.1 
ENSMUST00000305497.1 ENSMUSG00000131360 ENSMUST00000305497.1 ENSMUSG00000131360 (from geneSymbol) uc334tvg.1 uc334tvg.1 
ENSMUST00000305499.1 ENSMUSG00000131361 ENSMUST00000305499.1 ENSMUSG00000131361 (from geneSymbol) uc334tvi.1 uc334tvi.1 
ENSMUST00000305500.1 ENSMUSG00000131362 ENSMUST00000305500.1 ENSMUSG00000131362 (from geneSymbol) uc334tvj.1 uc334tvj.1 
ENSMUST00000305517.1 ENSMUSG00000131363 ENSMUST00000305517.1 ENSMUSG00000131363 (from geneSymbol) uc334twa.1 uc334twa.1 
ENSMUST00000305518.1 ENSMUSG00000131364 ENSMUST00000305518.1 ENSMUSG00000131364 (from geneSymbol) uc334twb.1 uc334twb.1 
ENSMUST00000305524.1 ENSMUSG00000131365 ENSMUST00000305524.1 ENSMUSG00000131365 (from geneSymbol) uc334twh.1 uc334twh.1 
ENSMUST00000305525.1 ENSMUSG00000131366 ENSMUST00000305525.1 ENSMUSG00000131366 (from geneSymbol) uc334twi.1 uc334twi.1 
ENSMUST00000305526.1 ENSMUSG00000131367 ENSMUST00000305526.1 ENSMUSG00000131367 (from geneSymbol) uc334twj.1 uc334twj.1 
ENSMUST00000305531.1 ENSMUSG00000131368 ENSMUST00000305531.1 ENSMUSG00000131368 (from geneSymbol) uc334two.1 uc334two.1 
ENSMUST00000305532.1 ENSMUSG00000131369 ENSMUST00000305532.1 ENSMUSG00000131369 (from geneSymbol) uc334twp.1 uc334twp.1 
ENSMUST00000305537.1 ENSMUSG00000131370 ENSMUST00000305537.1 ENSMUSG00000131370 (from geneSymbol) uc334twu.1 uc334twu.1 
ENSMUST00000305538.1 ENSMUSG00000131371 ENSMUST00000305538.1 ENSMUSG00000131371 (from geneSymbol) uc334twv.1 uc334twv.1 
ENSMUST00000305540.1 ENSMUSG00000131372 ENSMUST00000305540.1 ENSMUSG00000131372 (from geneSymbol) uc334twx.1 uc334twx.1 
ENSMUST00000305541.1 ENSMUSG00000131373 ENSMUST00000305541.1 ENSMUSG00000131373 (from geneSymbol) uc334twy.1 uc334twy.1 
ENSMUST00000305558.1 Gm57041 ENSMUST00000305558.1 Gm57041 (from geneSymbol) uc334txp.1 uc334txp.1 
ENSMUST00000305566.1 ENSMUSG00000131374 ENSMUST00000305566.1 ENSMUSG00000131374 (from geneSymbol) uc334txx.1 uc334txx.1 
ENSMUST00000305570.1 ENSMUSG00000131375 ENSMUST00000305570.1 ENSMUSG00000131375 (from geneSymbol) uc334tyb.1 uc334tyb.1 
ENSMUST00000305571.1 ENSMUSG00000131376 ENSMUST00000305571.1 ENSMUSG00000131376 (from geneSymbol) uc334tyc.1 uc334tyc.1 
ENSMUST00000305574.1 Gm41492 ENSMUST00000305574.1 Gm41492 (from geneSymbol) uc334tyf.1 uc334tyf.1 
ENSMUST00000305608.1 ENSMUSG00000131377 ENSMUST00000305608.1 ENSMUSG00000131377 (from geneSymbol) uc334tzn.1 uc334tzn.1 
ENSMUST00000305610.1 ENSMUSG00000131378 ENSMUST00000305610.1 ENSMUSG00000131378 (from geneSymbol) uc334tzp.1 uc334tzp.1 
ENSMUST00000305632.1 ENSMUSG00000131379 ENSMUST00000305632.1 ENSMUSG00000131379 (from geneSymbol) uc334ual.1 uc334ual.1 
ENSMUST00000305635.1 ENSMUSG00000131380 ENSMUST00000305635.1 ENSMUSG00000131380 (from geneSymbol) uc334uao.1 uc334uao.1 
ENSMUST00000305640.1 ENSMUSG00000131381 ENSMUST00000305640.1 ENSMUSG00000131381 (from geneSymbol) uc334uat.1 uc334uat.1 
ENSMUST00000305643.1 E130018N17Rik ENSMUST00000305643.1 E130018N17Rik (from geneSymbol) KY467921 uc334uaw.1 uc334uaw.1 
ENSMUST00000305650.1 ENSMUSG00000131382 ENSMUST00000305650.1 ENSMUSG00000131382 (from geneSymbol) uc334ubd.1 uc334ubd.1 
ENSMUST00000305651.1 ENSMUSG00000131383 ENSMUST00000305651.1 ENSMUSG00000131383 (from geneSymbol) uc334ube.1 uc334ube.1 
ENSMUST00000305652.1 ENSMUSG00000131384 ENSMUST00000305652.1 ENSMUSG00000131384 (from geneSymbol) uc334ubf.1 uc334ubf.1 
ENSMUST00000305653.1 ENSMUSG00000131385 ENSMUST00000305653.1 ENSMUSG00000131385 (from geneSymbol) uc334ubg.1 uc334ubg.1 
ENSMUST00000305654.1 ENSMUSG00000131386 ENSMUST00000305654.1 ENSMUSG00000131386 (from geneSymbol) uc334ubh.1 uc334ubh.1 
ENSMUST00000305655.1 ENSMUSG00000131387 ENSMUST00000305655.1 ENSMUSG00000131387 (from geneSymbol) uc334ubi.1 uc334ubi.1 
ENSMUST00000305656.1 ENSMUSG00000131388 ENSMUST00000305656.1 ENSMUSG00000131388 (from geneSymbol) uc334ubj.1 uc334ubj.1 
ENSMUST00000305657.1 ENSMUSG00000131389 ENSMUST00000305657.1 ENSMUSG00000131389 (from geneSymbol) uc334ubk.1 uc334ubk.1 
ENSMUST00000305661.1 ENSMUSG00000131390 ENSMUST00000305661.1 ENSMUSG00000131390 (from geneSymbol) uc334ubo.1 uc334ubo.1 
ENSMUST00000305662.1 ENSMUSG00000131391 ENSMUST00000305662.1 ENSMUSG00000131391 (from geneSymbol) uc334ubp.1 uc334ubp.1 
ENSMUST00000305663.1 ENSMUSG00000131392 ENSMUST00000305663.1 ENSMUSG00000131392 (from geneSymbol) uc334ubq.1 uc334ubq.1 
ENSMUST00000305665.1 ENSMUSG00000131393 ENSMUST00000305665.1 ENSMUSG00000131393 (from geneSymbol) uc334ubs.1 uc334ubs.1 
ENSMUST00000305666.1 ENSMUSG00000131394 ENSMUST00000305666.1 ENSMUSG00000131394 (from geneSymbol) uc334ubt.1 uc334ubt.1 
ENSMUST00000305669.1 ENSMUSG00000131395 ENSMUST00000305669.1 ENSMUSG00000131395 (from geneSymbol) uc334ubw.1 uc334ubw.1 
ENSMUST00000305670.1 ENSMUSG00000131396 ENSMUST00000305670.1 ENSMUSG00000131396 (from geneSymbol) uc334ubx.1 uc334ubx.1 
ENSMUST00000305671.1 Gm33023 ENSMUST00000305671.1 Gm33023 (from geneSymbol) AK006980 uc334uby.1 uc334uby.1 
ENSMUST00000305672.1 1700082M22Rik ENSMUST00000305672.1 1700082M22Rik (from geneSymbol) AK006980 uc334ubz.1 uc334ubz.1 
ENSMUST00000305675.1 ENSMUSG00000131397 ENSMUST00000305675.1 ENSMUSG00000131397 (from geneSymbol) uc334ucc.1 uc334ucc.1 
ENSMUST00000305676.1 ENSMUSG00000131398 ENSMUST00000305676.1 ENSMUSG00000131398 (from geneSymbol) uc334ucd.1 uc334ucd.1 
ENSMUST00000305678.1 ENSMUSG00000131399 ENSMUST00000305678.1 ENSMUSG00000131399 (from geneSymbol) uc334ucf.1 uc334ucf.1 
ENSMUST00000305681.1 ENSMUSG00000131400 ENSMUST00000305681.1 ENSMUSG00000131400 (from geneSymbol) uc334uci.1 uc334uci.1 
ENSMUST00000305686.1 ENSMUSG00000131401 ENSMUST00000305686.1 ENSMUSG00000131401 (from geneSymbol) uc334ucn.1 uc334ucn.1 
ENSMUST00000305688.1 ENSMUSG00000131402 ENSMUST00000305688.1 ENSMUSG00000131402 (from geneSymbol) uc334ucp.1 uc334ucp.1 
ENSMUST00000305692.1 ENSMUSG00000131403 ENSMUST00000305692.1 ENSMUSG00000131403 (from geneSymbol) FJ541091 uc334uct.1 uc334uct.1 
ENSMUST00000305697.1 ENSMUSG00000131404 ENSMUST00000305697.1 ENSMUSG00000131404 (from geneSymbol) uc334ucx.1 uc334ucx.1 
ENSMUST00000305714.1 ENSMUSG00000131405 ENSMUST00000305714.1 ENSMUSG00000131405 (from geneSymbol) uc334udo.1 uc334udo.1 
ENSMUST00000305715.1 ENSMUSG00000131406 ENSMUST00000305715.1 ENSMUSG00000131406 (from geneSymbol) uc334udp.1 uc334udp.1 
ENSMUST00000305716.1 ENSMUSG00000131407 ENSMUST00000305716.1 ENSMUSG00000131407 (from geneSymbol) uc334udq.1 uc334udq.1 
ENSMUST00000305717.1 Gm21123 ENSMUST00000305717.1 Gm21123 (from geneSymbol) AK156980 uc334udr.1 uc334udr.1 
ENSMUST00000305720.1 ENSMUSG00000131408 ENSMUST00000305720.1 ENSMUSG00000131408 (from geneSymbol) uc334udu.1 uc334udu.1 
ENSMUST00000305721.1 ENSMUSG00000131409 ENSMUST00000305721.1 ENSMUSG00000131409 (from geneSymbol) uc334udv.1 uc334udv.1 
ENSMUST00000305722.1 ENSMUSG00000131410 ENSMUST00000305722.1 ENSMUSG00000131410 (from geneSymbol) uc334udw.1 uc334udw.1 
ENSMUST00000305723.1 ENSMUSG00000131411 ENSMUST00000305723.1 ENSMUSG00000131411 (from geneSymbol) uc334udx.1 uc334udx.1 
ENSMUST00000305725.1 ENSMUSG00000131412 ENSMUST00000305725.1 ENSMUSG00000131412 (from geneSymbol) uc334udz.1 uc334udz.1 
ENSMUST00000305731.1 ENSMUSG00000131413 ENSMUST00000305731.1 ENSMUSG00000131413 (from geneSymbol) uc334uef.1 uc334uef.1 
ENSMUST00000305732.1 ENSMUSG00000131414 ENSMUST00000305732.1 ENSMUSG00000131414 (from geneSymbol) uc334ueg.1 uc334ueg.1 
ENSMUST00000305735.1 ENSMUSG00000131415 ENSMUST00000305735.1 ENSMUSG00000131415 (from geneSymbol) uc334uej.1 uc334uej.1 
ENSMUST00000305738.1 ENSMUSG00000131416 ENSMUST00000305738.1 ENSMUSG00000131416 (from geneSymbol) uc334uem.1 uc334uem.1 
ENSMUST00000305744.1 Gm31218 ENSMUST00000305744.1 Gm31218 (from geneSymbol) uc334ues.1 uc334ues.1 
ENSMUST00000305755.1 ENSMUSG00000131417 ENSMUST00000305755.1 ENSMUSG00000131417 (from geneSymbol) uc334ufc.1 uc334ufc.1 
ENSMUST00000305759.1 ENSMUSG00000131418 ENSMUST00000305759.1 ENSMUSG00000131418 (from geneSymbol) uc334ufg.1 uc334ufg.1 
ENSMUST00000305760.1 ENSMUSG00000131419 ENSMUST00000305760.1 ENSMUSG00000131419 (from geneSymbol) uc334ufh.1 uc334ufh.1 
ENSMUST00000305763.1 ENSMUSG00000131420 ENSMUST00000305763.1 ENSMUSG00000131420 (from geneSymbol) uc334ufk.1 uc334ufk.1 
ENSMUST00000305774.1 ENSMUSG00000131421 ENSMUST00000305774.1 ENSMUSG00000131421 (from geneSymbol) uc334ufv.1 uc334ufv.1 
ENSMUST00000305779.1 ENSMUSG00000131422 ENSMUST00000305779.1 ENSMUSG00000131422 (from geneSymbol) AK086870 uc334uga.1 uc334uga.1 
ENSMUST00000305785.1 ENSMUSG00000131423 ENSMUST00000305785.1 ENSMUSG00000131423 (from geneSymbol) uc334ugf.1 uc334ugf.1 
ENSMUST00000305786.1 ENSMUSG00000131424 ENSMUST00000305786.1 ENSMUSG00000131424 (from geneSymbol) uc334ugg.1 uc334ugg.1 
ENSMUST00000305788.1 ENSMUSG00000131425 ENSMUST00000305788.1 ENSMUSG00000131425 (from geneSymbol) uc334ugi.1 uc334ugi.1 
ENSMUST00000305793.1 ENSMUSG00000131426 ENSMUST00000305793.1 ENSMUSG00000131426 (from geneSymbol) uc334ugn.1 uc334ugn.1 
ENSMUST00000305795.1 ENSMUSG00000131427 ENSMUST00000305795.1 ENSMUSG00000131427 (from geneSymbol) uc334ugp.1 uc334ugp.1 
ENSMUST00000305798.1 ENSMUSG00000131428 ENSMUST00000305798.1 ENSMUSG00000131428 (from geneSymbol) uc334ugr.1 uc334ugr.1 
ENSMUST00000305799.1 ENSMUSG00000131429 ENSMUST00000305799.1 ENSMUSG00000131429 (from geneSymbol) uc334ugs.1 uc334ugs.1 
ENSMUST00000305800.1 ENSMUSG00000131430 ENSMUST00000305800.1 ENSMUSG00000131430 (from geneSymbol) uc334ugt.1 uc334ugt.1 
ENSMUST00000305801.1 ENSMUSG00000131431 ENSMUST00000305801.1 ENSMUSG00000131431 (from geneSymbol) uc334ugu.1 uc334ugu.1 
ENSMUST00000305806.1 ENSMUSG00000131432 ENSMUST00000305806.1 ENSMUSG00000131432 (from geneSymbol) uc334ugz.1 uc334ugz.1 
ENSMUST00000305810.1 ENSMUSG00000131433 ENSMUST00000305810.1 ENSMUSG00000131433 (from geneSymbol) uc334uhd.1 uc334uhd.1 
ENSMUST00000305819.1 ENSMUSG00000131434 ENSMUST00000305819.1 ENSMUSG00000131434 (from geneSymbol) uc334uhm.1 uc334uhm.1 
ENSMUST00000305820.1 ENSMUSG00000131435 ENSMUST00000305820.1 ENSMUSG00000131435 (from geneSymbol) uc334uhn.1 uc334uhn.1 
ENSMUST00000305821.1 ENSMUSG00000131436 ENSMUST00000305821.1 ENSMUSG00000131436 (from geneSymbol) uc334uho.1 uc334uho.1 
ENSMUST00000305837.1 ENSMUSG00000131437 ENSMUST00000305837.1 ENSMUSG00000131437 (from geneSymbol) uc334uie.1 uc334uie.1 
ENSMUST00000305843.1 Gm57150 ENSMUST00000305843.1 Gm57150 (from geneSymbol) uc334uik.1 uc334uik.1 
ENSMUST00000305851.1 ENSMUSG00000131438 ENSMUST00000305851.1 ENSMUSG00000131438 (from geneSymbol) uc334uis.1 uc334uis.1 
ENSMUST00000305852.1 ENSMUSG00000131439 ENSMUST00000305852.1 ENSMUSG00000131439 (from geneSymbol) uc334uit.1 uc334uit.1 
ENSMUST00000305854.1 ENSMUSG00000131440 ENSMUST00000305854.1 ENSMUSG00000131440 (from geneSymbol) uc334uiv.1 uc334uiv.1 
ENSMUST00000305882.1 ENSMUSG00000131441 ENSMUST00000305882.1 ENSMUSG00000131441 (from geneSymbol) uc334ujx.1 uc334ujx.1 
ENSMUST00000305883.1 Gm30400 ENSMUST00000305883.1 Gm30400 (from geneSymbol) AK164315 uc334ujy.1 uc334ujy.1 
ENSMUST00000305884.1 ENSMUSG00000131442 ENSMUST00000305884.1 ENSMUSG00000131442 (from geneSymbol) uc334ujz.1 uc334ujz.1 
ENSMUST00000305885.1 ENSMUSG00000131443 ENSMUST00000305885.1 ENSMUSG00000131443 (from geneSymbol) uc334uka.1 uc334uka.1 
ENSMUST00000305890.1 ENSMUSG00000131445 ENSMUST00000305890.1 ENSMUSG00000131445 (from geneSymbol) uc334uke.1 uc334uke.1 
ENSMUST00000305891.1 ENSMUSG00000131446 ENSMUST00000305891.1 ENSMUSG00000131446 (from geneSymbol) uc334ukf.1 uc334ukf.1 
ENSMUST00000305901.1 ENSMUSG00000131447 ENSMUST00000305901.1 ENSMUSG00000131447 (from geneSymbol) uc334uko.1 uc334uko.1 
ENSMUST00000305902.1 ENSMUSG00000131448 ENSMUST00000305902.1 ENSMUSG00000131448 (from geneSymbol) uc334ukp.1 uc334ukp.1 
ENSMUST00000305903.1 ENSMUSG00000131449 ENSMUST00000305903.1 ENSMUSG00000131449 (from geneSymbol) uc334ukq.1 uc334ukq.1 
ENSMUST00000305904.1 ENSMUSG00000131450 ENSMUST00000305904.1 ENSMUSG00000131450 (from geneSymbol) uc334ukr.1 uc334ukr.1 
ENSMUST00000305909.1 ENSMUSG00000131451 ENSMUST00000305909.1 ENSMUSG00000131451 (from geneSymbol) uc334ukw.1 uc334ukw.1 
ENSMUST00000305912.1 ENSMUSG00000131452 ENSMUST00000305912.1 ENSMUSG00000131452 (from geneSymbol) uc334ukz.1 uc334ukz.1 
ENSMUST00000305914.1 ENSMUSG00000131453 ENSMUST00000305914.1 ENSMUSG00000131453 (from geneSymbol) uc334ulb.1 uc334ulb.1 
ENSMUST00000305920.1 ENSMUSG00000131454 ENSMUST00000305920.1 ENSMUSG00000131454 (from geneSymbol) uc334ulh.1 uc334ulh.1 
ENSMUST00000305921.1 ENSMUSG00000131455 ENSMUST00000305921.1 ENSMUSG00000131455 (from geneSymbol) uc334uli.1 uc334uli.1 
ENSMUST00000305922.1 ENSMUSG00000131456 ENSMUST00000305922.1 ENSMUSG00000131456 (from geneSymbol) uc334ulj.1 uc334ulj.1 
ENSMUST00000305925.1 ENSMUSG00000131457 ENSMUST00000305925.1 ENSMUSG00000131457 (from geneSymbol) uc334ulm.1 uc334ulm.1 
ENSMUST00000305926.1 ENSMUSG00000131458 ENSMUST00000305926.1 ENSMUSG00000131458 (from geneSymbol) uc334uln.1 uc334uln.1 
ENSMUST00000305929.1 ENSMUSG00000131459 ENSMUST00000305929.1 ENSMUSG00000131459 (from geneSymbol) uc334ulq.1 uc334ulq.1 
ENSMUST00000305936.1 ENSMUSG00000131460 ENSMUST00000305936.1 ENSMUSG00000131460 (from geneSymbol) uc334ulw.1 uc334ulw.1 
ENSMUST00000305945.1 ENSMUSG00000131461 ENSMUST00000305945.1 ENSMUSG00000131461 (from geneSymbol) uc334umb.1 uc334umb.1 
ENSMUST00000305948.1 ENSMUSG00000131462 ENSMUST00000305948.1 ENSMUSG00000131462 (from geneSymbol) uc334ume.1 uc334ume.1 
ENSMUST00000305950.1 ENSMUSG00000131463 ENSMUST00000305950.1 ENSMUSG00000131463 (from geneSymbol) uc334umg.1 uc334umg.1 
ENSMUST00000305953.1 ENSMUSG00000131464 ENSMUST00000305953.1 ENSMUSG00000131464 (from geneSymbol) uc334umj.1 uc334umj.1 
ENSMUST00000305956.1 ENSMUSG00000131465 ENSMUST00000305956.1 ENSMUSG00000131465 (from geneSymbol) uc334umm.1 uc334umm.1 
ENSMUST00000305957.1 ENSMUSG00000131466 ENSMUST00000305957.1 ENSMUSG00000131466 (from geneSymbol) uc334umn.1 uc334umn.1 
ENSMUST00000305960.1 ENSMUSG00000131467 ENSMUST00000305960.1 ENSMUSG00000131467 (from geneSymbol) uc334umq.1 uc334umq.1 
ENSMUST00000305961.1 ENSMUSG00000131468 ENSMUST00000305961.1 ENSMUSG00000131468 (from geneSymbol) uc334umr.1 uc334umr.1 
ENSMUST00000305964.1 Gm29083 ENSMUST00000305964.1 Gm29083 (from geneSymbol) uc334umu.1 uc334umu.1 
ENSMUST00000305977.1 ENSMUSG00000131469 ENSMUST00000305977.1 ENSMUSG00000131469 (from geneSymbol) uc334unh.1 uc334unh.1 
ENSMUST00000305982.1 Gm49747 ENSMUST00000305982.1 Gm49747 (from geneSymbol) uc334unm.1 uc334unm.1 
ENSMUST00000305984.1 ENSMUSG00000131470 ENSMUST00000305984.1 ENSMUSG00000131470 (from geneSymbol) uc334uno.1 uc334uno.1 
ENSMUST00000305985.1 ENSMUSG00000131471 ENSMUST00000305985.1 ENSMUSG00000131471 (from geneSymbol) uc334unp.1 uc334unp.1 
ENSMUST00000305987.1 Gm13431 ENSMUST00000305987.1 Gm13431 (from geneSymbol) KY467855 uc334unr.1 uc334unr.1 
ENSMUST00000305988.1 Gm13429 ENSMUST00000305988.1 Gm13429 (from geneSymbol) KY467854 uc334uns.1 uc334uns.1 
ENSMUST00000306016.1 Gm26717 ENSMUST00000306016.1 Gm26717 (from geneSymbol) AK146643 uc334uou.1 uc334uou.1 
ENSMUST00000306018.1 ENSMUSG00000131472 ENSMUST00000306018.1 ENSMUSG00000131472 (from geneSymbol) uc334uow.1 uc334uow.1 
ENSMUST00000306020.1 ENSMUSG00000131473 ENSMUST00000306020.1 ENSMUSG00000131473 (from geneSymbol) uc334uoy.1 uc334uoy.1 
ENSMUST00000306021.1 B130024G19Rik ENSMUST00000306021.1 B130024G19Rik (from geneSymbol) BC070425 uc334uoz.1 uc334uoz.1 
ENSMUST00000306033.1 ENSMUSG00000131474 ENSMUST00000306033.1 ENSMUSG00000131474 (from geneSymbol) uc334upl.1 uc334upl.1 
ENSMUST00000306038.1 Gm44777 ENSMUST00000306038.1 Gm44777 (from geneSymbol) uc334upq.1 uc334upq.1 
ENSMUST00000306047.1 ENSMUSG00000131475 ENSMUST00000306047.1 ENSMUSG00000131475 (from geneSymbol) uc334upy.1 uc334upy.1 
ENSMUST00000306050.1 ENSMUSG00000131476 ENSMUST00000306050.1 ENSMUSG00000131476 (from geneSymbol) uc334uqb.1 uc334uqb.1 
ENSMUST00000306051.1 ENSMUSG00000131477 ENSMUST00000306051.1 ENSMUSG00000131477 (from geneSymbol) uc334uqc.1 uc334uqc.1 
ENSMUST00000306053.1 ENSMUSG00000131478 ENSMUST00000306053.1 ENSMUSG00000131478 (from geneSymbol) uc334uqe.1 uc334uqe.1 
ENSMUST00000306057.1 Gm42827 ENSMUST00000306057.1 Gm42827 (from geneSymbol) AK048871 uc334uqi.1 uc334uqi.1 
ENSMUST00000306066.1 ENSMUSG00000131479 ENSMUST00000306066.1 ENSMUSG00000131479 (from geneSymbol) uc334uqr.1 uc334uqr.1 
ENSMUST00000306067.1 6720427I07Rik ENSMUST00000306067.1 6720427I07Rik (from geneSymbol) KY467470 uc334uqs.1 uc334uqs.1 
ENSMUST00000306076.1 ENSMUSG00000131480 ENSMUST00000306076.1 ENSMUSG00000131480 (from geneSymbol) uc334urb.1 uc334urb.1 
ENSMUST00000306082.1 ENSMUSG00000131481 ENSMUST00000306082.1 ENSMUSG00000131481 (from geneSymbol) uc334urh.1 uc334urh.1 
ENSMUST00000306092.1 ENSMUSG00000131482 ENSMUST00000306092.1 ENSMUSG00000131482 (from geneSymbol) uc334urr.1 uc334urr.1 
ENSMUST00000306100.1 ENSMUSG00000131483 ENSMUST00000306100.1 ENSMUSG00000131483 (from geneSymbol) uc334urz.1 uc334urz.1 
ENSMUST00000306101.1 A430072P03Rik ENSMUST00000306101.1 A430072P03Rik (from geneSymbol) AK079802 uc334usa.1 uc334usa.1 
ENSMUST00000306104.1 ENSMUSG00000131484 ENSMUST00000306104.1 ENSMUSG00000131484 (from geneSymbol) uc334usd.1 uc334usd.1 
ENSMUST00000306106.1 ENSMUSG00000131485 ENSMUST00000306106.1 ENSMUSG00000131485 (from geneSymbol) uc334usf.1 uc334usf.1 
ENSMUST00000306115.1 ENSMUSG00000131486 ENSMUST00000306115.1 ENSMUSG00000131486 (from geneSymbol) uc334uso.1 uc334uso.1 
ENSMUST00000306117.1 ENSMUSG00000131487 ENSMUST00000306117.1 ENSMUSG00000131487 (from geneSymbol) uc334usq.1 uc334usq.1 
ENSMUST00000306118.1 ENSMUSG00000131488 ENSMUST00000306118.1 ENSMUSG00000131488 (from geneSymbol) uc334usr.1 uc334usr.1 
ENSMUST00000306131.1 ENSMUSG00000131490 ENSMUST00000306131.1 ENSMUSG00000131490 (from geneSymbol) uc334ust.1 uc334ust.1 
ENSMUST00000306134.1 ENSMUSG00000131491 ENSMUST00000306134.1 ENSMUSG00000131491 (from geneSymbol) uc334usw.1 uc334usw.1 
ENSMUST00000306137.1 Gm31981 ENSMUST00000306137.1 Gm31981 (from geneSymbol) uc334usz.1 uc334usz.1 
ENSMUST00000306145.1 ENSMUSG00000131493 ENSMUST00000306145.1 ENSMUSG00000131493 (from geneSymbol) uc334uth.1 uc334uth.1 
ENSMUST00000306147.1 ENSMUSG00000131494 ENSMUST00000306147.1 ENSMUSG00000131494 (from geneSymbol) uc334utj.1 uc334utj.1 
ENSMUST00000306148.1 Gm11739 ENSMUST00000306148.1 Gm11739 (from geneSymbol) uc334utk.1 uc334utk.1 
ENSMUST00000306150.1 ENSMUSG00000131495 ENSMUST00000306150.1 ENSMUSG00000131495 (from geneSymbol) uc334utm.1 uc334utm.1 
ENSMUST00000306157.1 9530062K07Rik ENSMUST00000306157.1 9530062K07Rik (from geneSymbol) AK020619 uc334utt.1 uc334utt.1 
ENSMUST00000306168.1 ENSMUSG00000131496 ENSMUST00000306168.1 ENSMUSG00000131496 (from geneSymbol) uc334uue.1 uc334uue.1 
ENSMUST00000306170.1 ENSMUSG00000131497 ENSMUST00000306170.1 ENSMUSG00000131497 (from geneSymbol) uc334uug.1 uc334uug.1 
ENSMUST00000306172.1 Gm47381 ENSMUST00000306172.1 Gm47381 (from geneSymbol) AK017011 uc334uui.1 uc334uui.1 
ENSMUST00000306185.1 ENSMUSG00000131498 ENSMUST00000306185.1 ENSMUSG00000131498 (from geneSymbol) uc334uuv.1 uc334uuv.1 
ENSMUST00000306193.1 ENSMUSG00000131499 ENSMUST00000306193.1 ENSMUSG00000131499 (from geneSymbol) uc334uvd.1 uc334uvd.1 
ENSMUST00000306194.1 ENSMUSG00000131500 ENSMUST00000306194.1 ENSMUSG00000131500 (from geneSymbol) uc334uve.1 uc334uve.1 
ENSMUST00000306195.1 ENSMUSG00000131501 ENSMUST00000306195.1 ENSMUSG00000131501 (from geneSymbol) uc334uvf.1 uc334uvf.1 
ENSMUST00000306197.1 ENSMUSG00000131502 ENSMUST00000306197.1 ENSMUSG00000131502 (from geneSymbol) uc334uvh.1 uc334uvh.1 
ENSMUST00000306199.1 4930405D01Rik ENSMUST00000306199.1 4930405D01Rik (from geneSymbol) AK015093 uc334uvj.1 uc334uvj.1 
ENSMUST00000306243.1 ENSMUSG00000131503 ENSMUST00000306243.1 ENSMUSG00000131503 (from geneSymbol) uc334uxb.1 uc334uxb.1 
ENSMUST00000306244.1 ENSMUSG00000131504 ENSMUST00000306244.1 ENSMUSG00000131504 (from geneSymbol) uc334uxc.1 uc334uxc.1 
ENSMUST00000306245.1 ENSMUSG00000131505 ENSMUST00000306245.1 ENSMUSG00000131505 (from geneSymbol) uc334uxd.1 uc334uxd.1 
ENSMUST00000306246.1 ENSMUSG00000131506 ENSMUST00000306246.1 ENSMUSG00000131506 (from geneSymbol) uc334uxe.1 uc334uxe.1 
ENSMUST00000306247.1 ENSMUSG00000131507 ENSMUST00000306247.1 ENSMUSG00000131507 (from geneSymbol) uc334uxf.1 uc334uxf.1 
ENSMUST00000306248.1 ENSMUSG00000131508 ENSMUST00000306248.1 ENSMUSG00000131508 (from geneSymbol) uc334uxg.1 uc334uxg.1 
ENSMUST00000306272.1 Gm56728 ENSMUST00000306272.1 Gm56728 (from geneSymbol) uc334uye.1 uc334uye.1 
ENSMUST00000306275.1 AV356131 ENSMUST00000306275.1 AV356131 (from geneSymbol) uc334uyh.1 uc334uyh.1 
ENSMUST00000306292.1 ENSMUSG00000131509 ENSMUST00000306292.1 ENSMUSG00000131509 (from geneSymbol) uc334uyy.1 uc334uyy.1 
ENSMUST00000306293.1 Scarletltr ENSMUST00000306293.1 Scarletltr (from geneSymbol) AK011166 uc334uyz.1 uc334uyz.1 
ENSMUST00000306304.1 ENSMUSG00000131510 ENSMUST00000306304.1 ENSMUSG00000131510 (from geneSymbol) uc334uzk.1 uc334uzk.1 
ENSMUST00000306306.1 ENSMUSG00000131511 ENSMUST00000306306.1 ENSMUSG00000131511 (from geneSymbol) uc334uzm.1 uc334uzm.1 
ENSMUST00000306311.1 ENSMUSG00000131512 ENSMUST00000306311.1 ENSMUSG00000131512 (from geneSymbol) uc334uzr.1 uc334uzr.1 
ENSMUST00000306313.1 ENSMUSG00000131513 ENSMUST00000306313.1 ENSMUSG00000131513 (from geneSymbol) uc334uzt.1 uc334uzt.1 
ENSMUST00000306332.1 ENSMUSG00000131514 ENSMUST00000306332.1 ENSMUSG00000131514 (from geneSymbol) uc334vam.1 uc334vam.1 
ENSMUST00000306333.1 ENSMUSG00000131515 ENSMUST00000306333.1 ENSMUSG00000131515 (from geneSymbol) uc334van.1 uc334van.1 
ENSMUST00000306345.1 ENSMUSG00000131516 ENSMUST00000306345.1 ENSMUSG00000131516 (from geneSymbol) uc334vaz.1 uc334vaz.1 
ENSMUST00000306353.1 ENSMUSG00000131517 ENSMUST00000306353.1 ENSMUSG00000131517 (from geneSymbol) uc334vbh.1 uc334vbh.1 
ENSMUST00000306354.1 ENSMUSG00000131518 ENSMUST00000306354.1 ENSMUSG00000131518 (from geneSymbol) uc334vbi.1 uc334vbi.1 
ENSMUST00000306355.1 ENSMUSG00000131519 ENSMUST00000306355.1 ENSMUSG00000131519 (from geneSymbol) uc334vbj.1 uc334vbj.1 
ENSMUST00000306357.1 ENSMUSG00000131520 ENSMUST00000306357.1 ENSMUSG00000131520 (from geneSymbol) uc334vbl.1 uc334vbl.1 
ENSMUST00000306360.1 ENSMUSG00000131521 ENSMUST00000306360.1 ENSMUSG00000131521 (from geneSymbol) uc334vbo.1 uc334vbo.1 
ENSMUST00000306361.1 ENSMUSG00000131522 ENSMUST00000306361.1 ENSMUSG00000131522 (from geneSymbol) uc334vbp.1 uc334vbp.1 
ENSMUST00000306368.1 ENSMUSG00000131523 ENSMUST00000306368.1 ENSMUSG00000131523 (from geneSymbol) uc334vbw.1 uc334vbw.1 
ENSMUST00000306369.1 ENSMUSG00000131524 ENSMUST00000306369.1 ENSMUSG00000131524 (from geneSymbol) uc334vbx.1 uc334vbx.1 
ENSMUST00000306371.1 ENSMUSG00000131525 ENSMUST00000306371.1 ENSMUSG00000131525 (from geneSymbol) uc334vbz.1 uc334vbz.1 
ENSMUST00000306375.1 Gm26685 ENSMUST00000306375.1 Gm26685 (from geneSymbol) AK033714 uc334vcd.1 uc334vcd.1 
ENSMUST00000306401.1 ENSMUSG00000131526 ENSMUST00000306401.1 ENSMUSG00000131526 (from geneSymbol) uc334vdd.1 uc334vdd.1 
ENSMUST00000306402.1 ENSMUSG00000131527 ENSMUST00000306402.1 ENSMUSG00000131527 (from geneSymbol) uc334vde.1 uc334vde.1 
ENSMUST00000306433.1 Gm56703 ENSMUST00000306433.1 Gm56703 (from geneSymbol) uc334vej.1 uc334vej.1 
ENSMUST00000306437.1 ENSMUSG00000131528 ENSMUST00000306437.1 ENSMUSG00000131528 (from geneSymbol) uc334ven.1 uc334ven.1 
ENSMUST00000306439.1 ENSMUSG00000131529 ENSMUST00000306439.1 ENSMUSG00000131529 (from geneSymbol) uc334vep.1 uc334vep.1 
ENSMUST00000306442.1 ENSMUSG00000131530 ENSMUST00000306442.1 ENSMUSG00000131530 (from geneSymbol) uc334ves.1 uc334ves.1 
ENSMUST00000306443.1 C330018A13Rik ENSMUST00000306443.1 C330018A13Rik (from geneSymbol) AK033917 uc334vet.1 uc334vet.1 
ENSMUST00000306446.1 ENSMUSG00000131531 ENSMUST00000306446.1 ENSMUSG00000131531 (from geneSymbol) uc334vew.1 uc334vew.1 
ENSMUST00000306464.1 ENSMUSG00000131534 ENSMUST00000306464.1 ENSMUSG00000131534 (from geneSymbol) uc334vfm.1 uc334vfm.1 
ENSMUST00000306466.1 ENSMUSG00000131535 ENSMUST00000306466.1 ENSMUSG00000131535 (from geneSymbol) uc334vfo.1 uc334vfo.1 
ENSMUST00000306468.1 ENSMUSG00000131536 ENSMUST00000306468.1 ENSMUSG00000131536 (from geneSymbol) uc334vfq.1 uc334vfq.1 
ENSMUST00000306469.1 ENSMUSG00000131537 ENSMUST00000306469.1 ENSMUSG00000131537 (from geneSymbol) uc334vfr.1 uc334vfr.1 
ENSMUST00000306470.1 ENSMUSG00000131538 ENSMUST00000306470.1 ENSMUSG00000131538 (from geneSymbol) uc334vfs.1 uc334vfs.1 
ENSMUST00000306472.1 ENSMUSG00000131539 ENSMUST00000306472.1 ENSMUSG00000131539 (from geneSymbol) uc334vfu.1 uc334vfu.1 
ENSMUST00000306473.1 ENSMUSG00000131540 ENSMUST00000306473.1 ENSMUSG00000131540 (from geneSymbol) uc334vfv.1 uc334vfv.1 
ENSMUST00000306474.1 ENSMUSG00000131541 ENSMUST00000306474.1 ENSMUSG00000131541 (from geneSymbol) uc334vfw.1 uc334vfw.1 
ENSMUST00000306477.1 ENSMUSG00000131542 ENSMUST00000306477.1 ENSMUSG00000131542 (from geneSymbol) uc334vfz.1 uc334vfz.1 
ENSMUST00000306479.1 ENSMUSG00000131543 ENSMUST00000306479.1 ENSMUSG00000131543 (from geneSymbol) uc334vgb.1 uc334vgb.1 
ENSMUST00000306493.1 ENSMUSG00000131544 ENSMUST00000306493.1 ENSMUSG00000131544 (from geneSymbol) uc334vgp.1 uc334vgp.1 
ENSMUST00000306496.1 ENSMUSG00000131545 ENSMUST00000306496.1 ENSMUSG00000131545 (from geneSymbol) uc334vgs.1 uc334vgs.1 
ENSMUST00000306497.1 ENSMUSG00000131546 ENSMUST00000306497.1 ENSMUSG00000131546 (from geneSymbol) uc334vgt.1 uc334vgt.1 
ENSMUST00000306499.1 Gm44867 ENSMUST00000306499.1 Gm44867 (from geneSymbol) uc334vgv.1 uc334vgv.1 
ENSMUST00000306505.1 ENSMUSG00000131547 ENSMUST00000306505.1 ENSMUSG00000131547 (from geneSymbol) uc334vhb.1 uc334vhb.1 
ENSMUST00000306509.1 ENSMUSG00000131548 ENSMUST00000306509.1 ENSMUSG00000131548 (from geneSymbol) uc334vhf.1 uc334vhf.1 
ENSMUST00000306512.1 Acss2os ENSMUST00000306512.1 Acss2os (from geneSymbol) AK015552 uc334vhi.1 uc334vhi.1 
ENSMUST00000306514.1 ENSMUSG00000131549 ENSMUST00000306514.1 ENSMUSG00000131549 (from geneSymbol) uc334vhk.1 uc334vhk.1 
ENSMUST00000306515.1 Gm47697 ENSMUST00000306515.1 Gm47697 (from geneSymbol) uc334vhl.1 uc334vhl.1 
ENSMUST00000306516.1 ENSMUSG00000131550 ENSMUST00000306516.1 ENSMUSG00000131550 (from geneSymbol) uc334vhm.1 uc334vhm.1 
ENSMUST00000306518.1 ENSMUSG00000131551 ENSMUST00000306518.1 ENSMUSG00000131551 (from geneSymbol) uc334vho.1 uc334vho.1 
ENSMUST00000306519.1 ENSMUSG00000131552 ENSMUST00000306519.1 ENSMUSG00000131552 (from geneSymbol) uc334vhp.1 uc334vhp.1 
ENSMUST00000306520.1 ENSMUSG00000131553 ENSMUST00000306520.1 ENSMUSG00000131553 (from geneSymbol) uc334vhq.1 uc334vhq.1 
ENSMUST00000306529.1 ENSMUSG00000131554 ENSMUST00000306529.1 ENSMUSG00000131554 (from geneSymbol) uc334vhz.1 uc334vhz.1 
ENSMUST00000306530.1 ENSMUSG00000131555 ENSMUST00000306530.1 ENSMUSG00000131555 (from geneSymbol) KY467979 uc334via.1 uc334via.1 
ENSMUST00000306534.1 ENSMUSG00000131556 ENSMUST00000306534.1 ENSMUSG00000131556 (from geneSymbol) uc334vie.1 uc334vie.1 
ENSMUST00000306556.1 ENSMUSG00000131557 ENSMUST00000306556.1 ENSMUSG00000131557 (from geneSymbol) uc334vja.1 uc334vja.1 
ENSMUST00000306558.1 ENSMUSG00000131558 ENSMUST00000306558.1 ENSMUSG00000131558 (from geneSymbol) uc334vjb.1 uc334vjb.1 
ENSMUST00000306559.1 ENSMUSG00000131559 ENSMUST00000306559.1 ENSMUSG00000131559 (from geneSymbol) uc334vjc.1 uc334vjc.1 
ENSMUST00000306561.1 Snhg15 ENSMUST00000306561.1 Snhg15 (from geneSymbol) KY467466 uc334vje.1 uc334vje.1 
ENSMUST00000306584.1 ENSMUSG00000131560 ENSMUST00000306584.1 ENSMUSG00000131560 (from geneSymbol) uc334vkb.1 uc334vkb.1 
ENSMUST00000306586.1 ENSMUSG00000121623 ENSMUST00000306586.1 ENSMUSG00000121623 (from geneSymbol) AK145544 uc334vkd.1 uc334vkd.1 
ENSMUST00000306591.1 ENSMUSG00000131561 ENSMUST00000306591.1 ENSMUSG00000131561 (from geneSymbol) uc334vki.1 uc334vki.1 
ENSMUST00000306593.1 ENSMUSG00000131562 ENSMUST00000306593.1 ENSMUSG00000131562 (from geneSymbol) uc334vkk.1 uc334vkk.1 
ENSMUST00000306594.1 ENSMUSG00000131563 ENSMUST00000306594.1 ENSMUSG00000131563 (from geneSymbol) uc334vkl.1 uc334vkl.1 
ENSMUST00000306597.1 ENSMUSG00000131564 ENSMUST00000306597.1 ENSMUSG00000131564 (from geneSymbol) uc334vko.1 uc334vko.1 
ENSMUST00000306598.1 ENSMUSG00000131565 ENSMUST00000306598.1 ENSMUSG00000131565 (from geneSymbol) uc334vkp.1 uc334vkp.1 
ENSMUST00000306599.1 ENSMUSG00000131566 ENSMUST00000306599.1 ENSMUSG00000131566 (from geneSymbol) uc334vkq.1 uc334vkq.1 
ENSMUST00000306603.1 ENSMUSG00000131567 ENSMUST00000306603.1 ENSMUSG00000131567 (from geneSymbol) uc334vku.1 uc334vku.1 
ENSMUST00000306604.1 ENSMUSG00000131568 ENSMUST00000306604.1 ENSMUSG00000131568 (from geneSymbol) uc334vkv.1 uc334vkv.1 
ENSMUST00000306605.1 ENSMUSG00000131569 ENSMUST00000306605.1 ENSMUSG00000131569 (from geneSymbol) uc334vkw.1 uc334vkw.1 
ENSMUST00000306606.1 ENSMUSG00000131570 ENSMUST00000306606.1 ENSMUSG00000131570 (from geneSymbol) uc334vkx.1 uc334vkx.1 
ENSMUST00000306607.1 ENSMUSG00000131571 ENSMUST00000306607.1 ENSMUSG00000131571 (from geneSymbol) uc334vky.1 uc334vky.1 
ENSMUST00000306609.1 ENSMUSG00000131572 ENSMUST00000306609.1 ENSMUSG00000131572 (from geneSymbol) uc334vla.1 uc334vla.1 
ENSMUST00000306611.1 Gm33195 ENSMUST00000306611.1 Gm33195 (from geneSymbol) uc334vlc.1 uc334vlc.1 
ENSMUST00000306622.1 ENSMUSG00000131573 ENSMUST00000306622.1 ENSMUSG00000131573 (from geneSymbol) uc334vln.1 uc334vln.1 
ENSMUST00000306623.1 ENSMUSG00000131574 ENSMUST00000306623.1 ENSMUSG00000131574 (from geneSymbol) uc334vlo.1 uc334vlo.1 
ENSMUST00000306624.1 ENSMUSG00000131575 ENSMUST00000306624.1 ENSMUSG00000131575 (from geneSymbol) uc334vlp.1 uc334vlp.1 
ENSMUST00000306625.1 ENSMUSG00000131576 ENSMUST00000306625.1 ENSMUSG00000131576 (from geneSymbol) AK082914 uc334vlq.1 uc334vlq.1 
ENSMUST00000306626.1 ENSMUSG00000131577 ENSMUST00000306626.1 ENSMUSG00000131577 (from geneSymbol) uc334vlr.1 uc334vlr.1 
ENSMUST00000306627.1 ENSMUSG00000131578 ENSMUST00000306627.1 ENSMUSG00000131578 (from geneSymbol) uc334vls.1 uc334vls.1 
ENSMUST00000306631.1 ENSMUSG00000131579 ENSMUST00000306631.1 ENSMUSG00000131579 (from geneSymbol) uc334vlw.1 uc334vlw.1 
ENSMUST00000306636.1 Gm36026 ENSMUST00000306636.1 Gm36026 (from geneSymbol) uc334vmb.1 uc334vmb.1 
ENSMUST00000306637.1 Gm10353 ENSMUST00000306637.1 predicted gene 10353 (from RefSeq NR_165499.1) NR_165499 uc334vmc.1 uc334vmc.1 
ENSMUST00000306638.1 ENSMUSG00000131580 ENSMUST00000306638.1 ENSMUSG00000131580 (from geneSymbol) uc334vmd.1 uc334vmd.1 
ENSMUST00000306642.1 Gm35396 ENSMUST00000306642.1 Gm35396 (from geneSymbol) uc334vmh.1 uc334vmh.1 
ENSMUST00000306660.1 ENSMUSG00000131582 ENSMUST00000306660.1 ENSMUSG00000131582 (from geneSymbol) uc334vmz.1 uc334vmz.1 
ENSMUST00000306673.1 ENSMUSG00000131583 ENSMUST00000306673.1 ENSMUSG00000131583 (from geneSymbol) uc334vnm.1 uc334vnm.1 
ENSMUST00000306678.1 ENSMUSG00000131584 ENSMUST00000306678.1 ENSMUSG00000131584 (from geneSymbol) uc334vnr.1 uc334vnr.1 
ENSMUST00000306683.1 ENSMUSG00000131585 ENSMUST00000306683.1 ENSMUSG00000131585 (from geneSymbol) uc334vnw.1 uc334vnw.1 
ENSMUST00000306684.1 ENSMUSG00000131586 ENSMUST00000306684.1 ENSMUSG00000131586 (from geneSymbol) uc334vnx.1 uc334vnx.1 
ENSMUST00000306685.1 ENSMUSG00000131587 ENSMUST00000306685.1 ENSMUSG00000131587 (from geneSymbol) uc334vny.1 uc334vny.1 
ENSMUST00000306688.1 1700055C04Rik ENSMUST00000306688.1 1700055C04Rik (from geneSymbol) uc334vob.1 uc334vob.1 
ENSMUST00000306690.1 ENSMUSG00000131588 ENSMUST00000306690.1 ENSMUSG00000131588 (from geneSymbol) uc334vod.1 uc334vod.1 
ENSMUST00000306692.1 Gm34499 ENSMUST00000306692.1 Gm34499 (from geneSymbol) uc334vof.1 uc334vof.1 
ENSMUST00000306697.1 ENSMUSG00000131589 ENSMUST00000306697.1 ENSMUSG00000131589 (from geneSymbol) uc334vok.1 uc334vok.1 
ENSMUST00000306698.1 ENSMUSG00000131590 ENSMUST00000306698.1 ENSMUSG00000131590 (from geneSymbol) uc334vol.1 uc334vol.1 
ENSMUST00000306699.1 ENSMUSG00000131591 ENSMUST00000306699.1 ENSMUSG00000131591 (from geneSymbol) uc334vom.1 uc334vom.1 
ENSMUST00000306700.1 ENSMUSG00000131592 ENSMUST00000306700.1 ENSMUSG00000131592 (from geneSymbol) uc334von.1 uc334von.1 
ENSMUST00000306705.1 ENSMUSG00000131593 ENSMUST00000306705.1 ENSMUSG00000131593 (from geneSymbol) uc334vos.1 uc334vos.1 
ENSMUST00000306706.1 ENSMUSG00000131594 ENSMUST00000306706.1 ENSMUSG00000131594 (from geneSymbol) uc334vot.1 uc334vot.1 
ENSMUST00000306707.1 ENSMUSG00000131595 ENSMUST00000306707.1 ENSMUSG00000131595 (from geneSymbol) uc334vou.1 uc334vou.1 
ENSMUST00000306708.1 ENSMUSG00000131596 ENSMUST00000306708.1 ENSMUSG00000131596 (from geneSymbol) uc334vov.1 uc334vov.1 
ENSMUST00000306709.1 ENSMUSG00000131597 ENSMUST00000306709.1 ENSMUSG00000131597 (from geneSymbol) uc334vow.1 uc334vow.1 
ENSMUST00000306711.1 ENSMUSG00000131598 ENSMUST00000306711.1 ENSMUSG00000131598 (from geneSymbol) uc334voy.1 uc334voy.1 
ENSMUST00000306712.1 ENSMUSG00000131599 ENSMUST00000306712.1 ENSMUSG00000131599 (from geneSymbol) uc334voz.1 uc334voz.1 
ENSMUST00000306722.1 ENSMUSG00000131600 ENSMUST00000306722.1 ENSMUSG00000131600 (from geneSymbol) uc334vpj.1 uc334vpj.1 
ENSMUST00000306725.1 Gm40983 ENSMUST00000306725.1 Gm40983 (from geneSymbol) uc334vpm.1 uc334vpm.1 
ENSMUST00000306731.1 ENSMUSG00000131601 ENSMUST00000306731.1 ENSMUSG00000131601 (from geneSymbol) uc334vps.1 uc334vps.1 
ENSMUST00000306732.1 ENSMUSG00000131602 ENSMUST00000306732.1 ENSMUSG00000131602 (from geneSymbol) uc334vpt.1 uc334vpt.1 
ENSMUST00000306733.1 ENSMUSG00000131603 ENSMUST00000306733.1 ENSMUSG00000131603 (from geneSymbol) uc334vpu.1 uc334vpu.1 
ENSMUST00000306734.1 ENSMUSG00000131604 ENSMUST00000306734.1 ENSMUSG00000131604 (from geneSymbol) AK132899 uc334vpv.1 uc334vpv.1 
ENSMUST00000306735.1 ENSMUSG00000131605 ENSMUST00000306735.1 ENSMUSG00000131605 (from geneSymbol) uc334vpw.1 uc334vpw.1 
ENSMUST00000306736.1 ENSMUSG00000131606 ENSMUST00000306736.1 ENSMUSG00000131606 (from geneSymbol) uc334vpx.1 uc334vpx.1 
ENSMUST00000306738.1 ENSMUSG00000131607 ENSMUST00000306738.1 ENSMUSG00000131607 (from geneSymbol) uc334vpz.1 uc334vpz.1 
ENSMUST00000306740.1 ENSMUSG00000131608 ENSMUST00000306740.1 ENSMUSG00000131608 (from geneSymbol) uc334vqb.1 uc334vqb.1 
ENSMUST00000306741.1 ENSMUSG00000131609 ENSMUST00000306741.1 ENSMUSG00000131609 (from geneSymbol) uc334vqc.1 uc334vqc.1 
ENSMUST00000306764.1 ENSMUSG00000131610 ENSMUST00000306764.1 ENSMUSG00000131610 (from geneSymbol) uc334vqz.1 uc334vqz.1 
ENSMUST00000306765.1 ENSMUSG00000131611 ENSMUST00000306765.1 ENSMUSG00000131611 (from geneSymbol) LF193708 uc334vra.1 uc334vra.1 
ENSMUST00000306766.1 ENSMUSG00000131612 ENSMUST00000306766.1 ENSMUSG00000131612 (from geneSymbol) uc334vrb.1 uc334vrb.1 
ENSMUST00000306767.1 1700042D02Rik ENSMUST00000306767.1 1700042D02Rik (from geneSymbol) AK006681 uc334vrc.1 uc334vrc.1 
ENSMUST00000306776.1 ENSMUSG00000131613 ENSMUST00000306776.1 ENSMUSG00000131613 (from geneSymbol) uc334vrl.1 uc334vrl.1 
ENSMUST00000306817.1 ENSMUSG00000131614 ENSMUST00000306817.1 ENSMUSG00000131614 (from geneSymbol) uc334vta.1 uc334vta.1 
ENSMUST00000306821.1 Gm57153 ENSMUST00000306821.1 Gm57153 (from geneSymbol) uc334vtd.1 uc334vtd.1 
ENSMUST00000306824.1 ENSMUSG00000131616 ENSMUST00000306824.1 ENSMUSG00000131616 (from geneSymbol) uc334vtg.1 uc334vtg.1 
ENSMUST00000306825.1 ENSMUSG00000131617 ENSMUST00000306825.1 ENSMUSG00000131617 (from geneSymbol) uc334vth.1 uc334vth.1 
ENSMUST00000306826.1 Gm26641 ENSMUST00000306826.1 Gm26641 (from geneSymbol) AK085275 uc334vti.1 uc334vti.1 
ENSMUST00000306828.1 ENSMUSG00000131618 ENSMUST00000306828.1 ENSMUSG00000131618 (from geneSymbol) uc334vtk.1 uc334vtk.1 
ENSMUST00000306831.1 ENSMUSG00000131619 ENSMUST00000306831.1 ENSMUSG00000131619 (from geneSymbol) uc334vtn.1 uc334vtn.1 
ENSMUST00000306835.1 ENSMUSG00000131620 ENSMUST00000306835.1 ENSMUSG00000131620 (from geneSymbol) uc334vtr.1 uc334vtr.1 
ENSMUST00000306845.1 ENSMUSG00000131621 ENSMUST00000306845.1 ENSMUSG00000131621 (from geneSymbol) AB343953 uc334vub.1 uc334vub.1 
ENSMUST00000306846.1 ENSMUSG00000131622 ENSMUST00000306846.1 ENSMUSG00000131622 (from geneSymbol) uc334vuc.1 uc334vuc.1 
ENSMUST00000306847.1 ENSMUSG00000131623 ENSMUST00000306847.1 ENSMUSG00000131623 (from geneSymbol) uc334vud.1 uc334vud.1 
ENSMUST00000306848.1 ENSMUSG00000131624 ENSMUST00000306848.1 ENSMUSG00000131624 (from geneSymbol) uc334vue.1 uc334vue.1 
ENSMUST00000306850.1 ENSMUSG00000131625 ENSMUST00000306850.1 ENSMUSG00000131625 (from geneSymbol) uc334vug.1 uc334vug.1 
ENSMUST00000306854.1 Aknaos ENSMUST00000306854.1 Aknaos (from geneSymbol) AK017104 uc334vuk.1 uc334vuk.1 
ENSMUST00000306866.1 ENSMUSG00000131626 ENSMUST00000306866.1 ENSMUSG00000131626 (from geneSymbol) uc334vuw.1 uc334vuw.1 
ENSMUST00000306867.1 ENSMUSG00000131627 ENSMUST00000306867.1 ENSMUSG00000131627 (from geneSymbol) uc334vux.1 uc334vux.1 
ENSMUST00000306868.1 ENSMUSG00000131628 ENSMUST00000306868.1 ENSMUSG00000131628 (from geneSymbol) uc334vuy.1 uc334vuy.1 
ENSMUST00000306869.1 ENSMUSG00000131629 ENSMUST00000306869.1 ENSMUSG00000131629 (from geneSymbol) uc334vuz.1 uc334vuz.1 
ENSMUST00000306874.1 ENSMUSG00000131630 ENSMUST00000306874.1 ENSMUSG00000131630 (from geneSymbol) uc334vve.1 uc334vve.1 
ENSMUST00000306876.1 6720468P15Rik ENSMUST00000306876.1 6720468P15Rik (from geneSymbol) AK020151 uc334vvg.1 uc334vvg.1 
ENSMUST00000306889.1 ENSMUSG00000131631 ENSMUST00000306889.1 ENSMUSG00000131631 (from geneSymbol) AK021204 uc334vvt.1 uc334vvt.1 
ENSMUST00000306918.1 ENSMUSG00000131632 ENSMUST00000306918.1 ENSMUSG00000131632 (from geneSymbol) uc334vww.1 uc334vww.1 
ENSMUST00000306920.1 ENSMUSG00000131633 ENSMUST00000306920.1 ENSMUSG00000131633 (from geneSymbol) uc334vwy.1 uc334vwy.1 
ENSMUST00000306921.1 ENSMUSG00000131634 ENSMUST00000306921.1 ENSMUSG00000131634 (from geneSymbol) AK018513 uc334vwz.1 uc334vwz.1 
ENSMUST00000306923.1 ENSMUSG00000131635 ENSMUST00000306923.1 ENSMUSG00000131635 (from geneSymbol) uc334vxb.1 uc334vxb.1 
ENSMUST00000306924.1 Gm6650 ENSMUST00000306924.1 Gm6650 (from geneSymbol) uc334vxc.1 uc334vxc.1 
ENSMUST00000306925.1 ENSMUSG00000131637 ENSMUST00000306925.1 ENSMUSG00000131637 (from geneSymbol) uc334vxd.1 uc334vxd.1 
ENSMUST00000306926.1 ENSMUSG00000131638 ENSMUST00000306926.1 ENSMUSG00000131638 (from geneSymbol) uc334vxe.1 uc334vxe.1 
ENSMUST00000306928.1 ENSMUSG00000131639 ENSMUST00000306928.1 ENSMUSG00000131639 (from geneSymbol) uc334vxg.1 uc334vxg.1 
ENSMUST00000306929.1 Gm19428 ENSMUST00000306929.1 Gm19428 (from geneSymbol) uc334vxh.1 uc334vxh.1 
ENSMUST00000306932.1 ENSMUSG00000131641 ENSMUST00000306932.1 ENSMUSG00000131641 (from geneSymbol) uc334vxk.1 uc334vxk.1 
ENSMUST00000306933.1 Gm57253 ENSMUST00000306933.1 Gm57253 (from geneSymbol) uc334vxl.1 uc334vxl.1 
ENSMUST00000306945.1 ENSMUSG00000131642 ENSMUST00000306945.1 ENSMUSG00000131642 (from geneSymbol) uc334vxx.1 uc334vxx.1 
ENSMUST00000306946.1 ENSMUSG00000131643 ENSMUST00000306946.1 ENSMUSG00000131643 (from geneSymbol) uc334vxy.1 uc334vxy.1 
ENSMUST00000306950.1 ENSMUSG00000131644 ENSMUST00000306950.1 ENSMUSG00000131644 (from geneSymbol) uc334vyc.1 uc334vyc.1 
ENSMUST00000306953.1 ENSMUSG00000131645 ENSMUST00000306953.1 ENSMUSG00000131645 (from geneSymbol) uc334vyf.1 uc334vyf.1 
ENSMUST00000306955.1 ENSMUSG00000131646 ENSMUST00000306955.1 ENSMUSG00000131646 (from geneSymbol) uc334vyh.1 uc334vyh.1 
ENSMUST00000306960.1 ENSMUSG00000131647 ENSMUST00000306960.1 ENSMUSG00000131647 (from geneSymbol) uc334vym.1 uc334vym.1 
ENSMUST00000306961.1 ENSMUSG00000131648 ENSMUST00000306961.1 ENSMUSG00000131648 (from geneSymbol) DQ559288 uc334vyn.1 uc334vyn.1 
ENSMUST00000306962.1 Nr6a1os ENSMUST00000306962.1 nuclear receptor subfamily 6, group A, member 1, opposite strand, transcript variant 25 (from RefSeq NR_190033.1) NR_190033 uc334vyo.1 uc334vyo.1 
ENSMUST00000306964.1 ENSMUSG00000131649 ENSMUST00000306964.1 ENSMUSG00000131649 (from geneSymbol) uc334vyq.1 uc334vyq.1 
ENSMUST00000306966.1 ENSMUSG00000131650 ENSMUST00000306966.1 ENSMUSG00000131650 (from geneSymbol) uc334vys.1 uc334vys.1 
ENSMUST00000306968.1 ENSMUSG00000131651 ENSMUST00000306968.1 ENSMUSG00000131651 (from geneSymbol) uc334vyu.1 uc334vyu.1 
ENSMUST00000306969.1 Gm40293 ENSMUST00000306969.1 Gm40293 (from geneSymbol) uc334vyv.1 uc334vyv.1 
ENSMUST00000307018.1 ENSMUSG00000131652 ENSMUST00000307018.1 ENSMUSG00000131652 (from geneSymbol) AK133601 uc334was.1 uc334was.1 
ENSMUST00000307019.1 ENSMUSG00000131653 ENSMUST00000307019.1 ENSMUSG00000131653 (from geneSymbol) AK145347 uc334wat.1 uc334wat.1 
ENSMUST00000307020.1 ENSMUSG00000131654 ENSMUST00000307020.1 ENSMUSG00000131654 (from geneSymbol) uc334wau.1 uc334wau.1 
ENSMUST00000307022.1 ENSMUSG00000131655 ENSMUST00000307022.1 ENSMUSG00000131655 (from geneSymbol) uc334waw.1 uc334waw.1 
ENSMUST00000307027.1 ENSMUSG00000131656 ENSMUST00000307027.1 ENSMUSG00000131656 (from geneSymbol) uc334wbb.1 uc334wbb.1 
ENSMUST00000307028.1 C130021I20Rik ENSMUST00000307028.1 C130021I20Rik (from geneSymbol) AK081497 uc334wbc.1 uc334wbc.1 
ENSMUST00000307038.1 ENSMUSG00000131657 ENSMUST00000307038.1 ENSMUSG00000131657 (from geneSymbol) uc334wbm.1 uc334wbm.1 
ENSMUST00000307039.1 ENSMUSG00000131658 ENSMUST00000307039.1 ENSMUSG00000131658 (from geneSymbol) uc334wbn.1 uc334wbn.1 
ENSMUST00000307040.1 ENSMUSG00000131659 ENSMUST00000307040.1 ENSMUSG00000131659 (from geneSymbol) uc334wbo.1 uc334wbo.1 
ENSMUST00000307041.1 Gm36756 ENSMUST00000307041.1 Gm36756 (from geneSymbol) uc334wbp.1 uc334wbp.1 
ENSMUST00000307049.1 Gm47639 ENSMUST00000307049.1 Gm47639 (from geneSymbol) uc334wbx.1 uc334wbx.1 
ENSMUST00000307059.1 ENSMUSG00000131660 ENSMUST00000307059.1 ENSMUSG00000131660 (from geneSymbol) uc334wch.1 uc334wch.1 
ENSMUST00000307060.1 ENSMUSG00000131661 ENSMUST00000307060.1 ENSMUSG00000131661 (from geneSymbol) uc334wci.1 uc334wci.1 
ENSMUST00000307062.1 ENSMUSG00000131662 ENSMUST00000307062.1 ENSMUSG00000131662 (from geneSymbol) uc334wck.1 uc334wck.1 
ENSMUST00000307070.1 ENSMUSG00000131663 ENSMUST00000307070.1 ENSMUSG00000131663 (from geneSymbol) uc334wcs.1 uc334wcs.1 
ENSMUST00000307072.1 ENSMUSG00000131664 ENSMUST00000307072.1 ENSMUSG00000131664 (from geneSymbol) uc334wcu.1 uc334wcu.1 
ENSMUST00000307073.1 ENSMUSG00000131665 ENSMUST00000307073.1 ENSMUSG00000131665 (from geneSymbol) uc334wcv.1 uc334wcv.1 
ENSMUST00000307074.1 ENSMUSG00000131666 ENSMUST00000307074.1 ENSMUSG00000131666 (from geneSymbol) uc334wcw.1 uc334wcw.1 
ENSMUST00000307077.1 ENSMUSG00000131667 ENSMUST00000307077.1 ENSMUSG00000131667 (from geneSymbol) uc334wcz.1 uc334wcz.1 
ENSMUST00000307079.1 ENSMUSG00000131668 ENSMUST00000307079.1 ENSMUSG00000131668 (from geneSymbol) uc334wdb.1 uc334wdb.1 
ENSMUST00000307089.1 ENSMUSG00000131669 ENSMUST00000307089.1 ENSMUSG00000131669 (from geneSymbol) uc334wdl.1 uc334wdl.1 
ENSMUST00000307097.1 1700100L14Rik ENSMUST00000307097.1 1700100L14Rik (from geneSymbol) AK007102 uc334wdt.1 uc334wdt.1 
ENSMUST00000307104.1 ENSMUSG00000131670 ENSMUST00000307104.1 ENSMUSG00000131670 (from geneSymbol) uc334wea.1 uc334wea.1 
ENSMUST00000307112.1 ENSMUSG00000131671 ENSMUST00000307112.1 ENSMUSG00000131671 (from geneSymbol) uc334wei.1 uc334wei.1 
ENSMUST00000307115.1 ENSMUSG00000131672 ENSMUST00000307115.1 ENSMUSG00000131672 (from geneSymbol) uc334wel.1 uc334wel.1 
ENSMUST00000307117.1 Platr7 ENSMUST00000307117.1 Platr7 (from geneSymbol) AK082870 uc334wen.1 uc334wen.1 
ENSMUST00000307132.1 ENSMUSG00000131673 ENSMUST00000307132.1 ENSMUSG00000131673 (from geneSymbol) uc334wfc.1 uc334wfc.1 
ENSMUST00000307136.1 ENSMUSG00000131674 ENSMUST00000307136.1 ENSMUSG00000131674 (from geneSymbol) uc334wfg.1 uc334wfg.1 
ENSMUST00000307137.1 ENSMUSG00000131675 ENSMUST00000307137.1 ENSMUSG00000131675 (from geneSymbol) uc334wfh.1 uc334wfh.1 
ENSMUST00000307138.1 8430436N08Rik ENSMUST00000307138.1 8430436N08Rik (from geneSymbol) AK018465 uc334wfi.1 uc334wfi.1 
ENSMUST00000307141.1 ENSMUSG00000131676 ENSMUST00000307141.1 ENSMUSG00000131676 (from geneSymbol) uc334wfl.1 uc334wfl.1 
ENSMUST00000307142.1 ENSMUSG00000131677 ENSMUST00000307142.1 ENSMUSG00000131677 (from geneSymbol) uc334wfm.1 uc334wfm.1 
ENSMUST00000307149.1 Gm16272 ENSMUST00000307149.1 Gm16272 (from geneSymbol) uc334wft.1 uc334wft.1 
ENSMUST00000307151.1 ENSMUSG00000131678 ENSMUST00000307151.1 ENSMUSG00000131678 (from geneSymbol) uc334wfv.1 uc334wfv.1 
ENSMUST00000307154.1 ENSMUSG00000131679 ENSMUST00000307154.1 ENSMUSG00000131679 (from geneSymbol) uc334wfy.1 uc334wfy.1 
ENSMUST00000307159.1 ENSMUSG00000131680 ENSMUST00000307159.1 ENSMUSG00000131680 (from geneSymbol) uc334wgb.1 uc334wgb.1 
ENSMUST00000307163.1 ENSMUSG00000131681 ENSMUST00000307163.1 ENSMUSG00000131681 (from geneSymbol) uc334wgf.1 uc334wgf.1 
ENSMUST00000307164.1 ENSMUSG00000131682 ENSMUST00000307164.1 ENSMUSG00000131682 (from geneSymbol) LF195181 uc334wgg.1 uc334wgg.1 
ENSMUST00000307165.1 Gm15200 ENSMUST00000307165.1 Gm15200 (from geneSymbol) AK138829 uc334wgh.1 uc334wgh.1 
ENSMUST00000307167.1 ENSMUSG00000131683 ENSMUST00000307167.1 ENSMUSG00000131683 (from geneSymbol) uc334wgj.1 uc334wgj.1 
ENSMUST00000307168.1 ENSMUSG00000131684 ENSMUST00000307168.1 ENSMUSG00000131684 (from geneSymbol) uc334wgk.1 uc334wgk.1 
ENSMUST00000307172.1 Gm40923 ENSMUST00000307172.1 Gm40923 (from geneSymbol) uc334wgo.1 uc334wgo.1 
ENSMUST00000307185.1 ENSMUSG00000131685 ENSMUST00000307185.1 ENSMUSG00000131685 (from geneSymbol) AK019607 uc334whb.1 uc334whb.1 
ENSMUST00000307186.1 ENSMUSG00000131686 ENSMUST00000307186.1 ENSMUSG00000131686 (from geneSymbol) uc334whc.1 uc334whc.1 
ENSMUST00000307187.1 ENSMUSG00000131687 ENSMUST00000307187.1 ENSMUSG00000131687 (from geneSymbol) uc334whd.1 uc334whd.1 
ENSMUST00000307188.1 ENSMUSG00000131688 ENSMUST00000307188.1 ENSMUSG00000131688 (from geneSymbol) uc334whe.1 uc334whe.1 
ENSMUST00000307189.1 1700030M09Rik ENSMUST00000307189.1 1700030M09Rik (from geneSymbol) AK006561 uc334whf.1 uc334whf.1 
ENSMUST00000307192.1 ENSMUSG00000131689 ENSMUST00000307192.1 ENSMUSG00000131689 (from geneSymbol) uc334whi.1 uc334whi.1 
ENSMUST00000307199.1 Gm40292 ENSMUST00000307199.1 Gm40292 (from geneSymbol) AK076853 uc334whp.1 uc334whp.1 
ENSMUST00000307215.1 ENSMUSG00000131690 ENSMUST00000307215.1 ENSMUSG00000131690 (from geneSymbol) uc334wif.1 uc334wif.1 
ENSMUST00000307216.1 ENSMUSG00000131691 ENSMUST00000307216.1 ENSMUSG00000131691 (from geneSymbol) uc334wig.1 uc334wig.1 
ENSMUST00000307218.1 ENSMUSG00000131692 ENSMUST00000307218.1 ENSMUSG00000131692 (from geneSymbol) uc334wii.1 uc334wii.1 
ENSMUST00000307221.1 ENSMUSG00000131693 ENSMUST00000307221.1 ENSMUSG00000131693 (from geneSymbol) uc334wil.1 uc334wil.1 
ENSMUST00000307224.1 ENSMUSG00000131694 ENSMUST00000307224.1 ENSMUSG00000131694 (from geneSymbol) uc334wio.1 uc334wio.1 
ENSMUST00000307225.1 ENSMUSG00000131695 ENSMUST00000307225.1 ENSMUSG00000131695 (from geneSymbol) uc334wip.1 uc334wip.1 
ENSMUST00000307226.1 ENSMUSG00000131696 ENSMUST00000307226.1 ENSMUSG00000131696 (from geneSymbol) AK145736 uc334wiq.1 uc334wiq.1 
ENSMUST00000307227.1 ENSMUSG00000131697 ENSMUST00000307227.1 ENSMUSG00000131697 (from geneSymbol) uc334wir.1 uc334wir.1 
ENSMUST00000307228.1 ENSMUSG00000131698 ENSMUST00000307228.1 ENSMUSG00000131698 (from geneSymbol) uc334wis.1 uc334wis.1 
ENSMUST00000307231.1 ENSMUSG00000131699 ENSMUST00000307231.1 ENSMUSG00000131699 (from geneSymbol) uc334wiv.1 uc334wiv.1 
ENSMUST00000307236.1 ENSMUSG00000131700 ENSMUST00000307236.1 ENSMUSG00000131700 (from geneSymbol) uc334wja.1 uc334wja.1 
ENSMUST00000307238.1 ENSMUSG00000131701 ENSMUST00000307238.1 ENSMUSG00000131701 (from geneSymbol) uc334wjc.1 uc334wjc.1 
ENSMUST00000307250.1 ENSMUSG00000131702 ENSMUST00000307250.1 ENSMUSG00000131702 (from geneSymbol) uc334wjo.1 uc334wjo.1 
ENSMUST00000307252.1 ENSMUSG00000131703 ENSMUST00000307252.1 ENSMUSG00000131703 (from geneSymbol) uc334wjq.1 uc334wjq.1 
ENSMUST00000307253.1 ENSMUSG00000131704 ENSMUST00000307253.1 ENSMUSG00000131704 (from geneSymbol) uc334wjr.1 uc334wjr.1 
ENSMUST00000307254.1 ENSMUSG00000131705 ENSMUST00000307254.1 ENSMUSG00000131705 (from geneSymbol) uc334wjs.1 uc334wjs.1 
ENSMUST00000307255.1 ENSMUSG00000131706 ENSMUST00000307255.1 ENSMUSG00000131706 (from geneSymbol) uc334wjt.1 uc334wjt.1 
ENSMUST00000307256.1 ENSMUSG00000131707 ENSMUST00000307256.1 ENSMUSG00000131707 (from geneSymbol) uc334wju.1 uc334wju.1 
ENSMUST00000307258.1 ENSMUSG00000131708 ENSMUST00000307258.1 ENSMUSG00000131708 (from geneSymbol) uc334wjw.1 uc334wjw.1 
ENSMUST00000307260.1 ENSMUSG00000131709 ENSMUST00000307260.1 ENSMUSG00000131709 (from geneSymbol) uc334wjy.1 uc334wjy.1 
ENSMUST00000307263.1 ENSMUSG00000131710 ENSMUST00000307263.1 ENSMUSG00000131710 (from geneSymbol) uc334wkb.1 uc334wkb.1 
ENSMUST00000307264.1 ENSMUSG00000131711 ENSMUST00000307264.1 ENSMUSG00000131711 (from geneSymbol) uc334wkc.1 uc334wkc.1 
ENSMUST00000307267.1 ENSMUSG00000131713 ENSMUST00000307267.1 ENSMUSG00000131713 (from geneSymbol) uc334wke.1 uc334wke.1 
ENSMUST00000307268.1 ENSMUSG00000131714 ENSMUST00000307268.1 ENSMUSG00000131714 (from geneSymbol) uc334wkf.1 uc334wkf.1 
ENSMUST00000307269.1 ENSMUSG00000131715 ENSMUST00000307269.1 ENSMUSG00000131715 (from geneSymbol) uc334wkg.1 uc334wkg.1 
ENSMUST00000307270.1 ENSMUSG00000131716 ENSMUST00000307270.1 ENSMUSG00000131716 (from geneSymbol) uc334wkh.1 uc334wkh.1 
ENSMUST00000307271.1 ENSMUSG00000131717 ENSMUST00000307271.1 ENSMUSG00000131717 (from geneSymbol) uc334wki.1 uc334wki.1 
ENSMUST00000307272.1 ENSMUSG00000131718 ENSMUST00000307272.1 ENSMUSG00000131718 (from geneSymbol) uc334wkj.1 uc334wkj.1 
ENSMUST00000307274.1 Gm11651 ENSMUST00000307274.1 Gm11651 (from geneSymbol) AK016887 uc334wkl.1 uc334wkl.1 
ENSMUST00000307307.1 ENSMUSG00000131719 ENSMUST00000307307.1 ENSMUSG00000131719 (from geneSymbol) uc334wls.1 uc334wls.1 
ENSMUST00000307309.1 Gm28959 ENSMUST00000307309.1 Gm28959 (from geneSymbol) uc334wlu.1 uc334wlu.1 
ENSMUST00000307311.1 ENSMUSG00000131720 ENSMUST00000307311.1 ENSMUSG00000131720 (from geneSymbol) uc334wlw.1 uc334wlw.1 
ENSMUST00000307317.1 ENSMUSG00000131721 ENSMUST00000307317.1 ENSMUSG00000131721 (from geneSymbol) uc334wmc.1 uc334wmc.1 
ENSMUST00000307318.1 ENSMUSG00000131722 ENSMUST00000307318.1 ENSMUSG00000131722 (from geneSymbol) uc334wmd.1 uc334wmd.1 
ENSMUST00000307319.1 ENSMUSG00000131723 ENSMUST00000307319.1 ENSMUSG00000131723 (from geneSymbol) uc334wme.1 uc334wme.1 
ENSMUST00000307348.1 ENSMUSG00000131724 ENSMUST00000307348.1 ENSMUSG00000131724 (from geneSymbol) uc334wnh.1 uc334wnh.1 
ENSMUST00000307365.1 ENSMUSG00000131725 ENSMUST00000307365.1 ENSMUSG00000131725 (from geneSymbol) uc334wny.1 uc334wny.1 
ENSMUST00000307374.1 Gm36719 ENSMUST00000307374.1 Gm36719 (from geneSymbol) uc334woh.1 uc334woh.1 
ENSMUST00000307379.1 Mir99ahg ENSMUST00000307379.1 Mir99ahg (from geneSymbol) AK012955 uc334wom.1 uc334wom.1 
ENSMUST00000307543.1 4833407H14Rik ENSMUST00000307543.1 4833407H14Rik (from geneSymbol) KY467827 uc334wur.1 uc334wur.1 
ENSMUST00000307603.1 A230103O09Rik ENSMUST00000307603.1 A230103O09Rik (from geneSymbol) AK020710 uc334wwz.1 uc334wwz.1 
ENSMUST00000307622.1 ENSMUSG00000131726 ENSMUST00000307622.1 ENSMUSG00000131726 (from geneSymbol) uc334wxs.1 uc334wxs.1 
ENSMUST00000307623.1 1700121L16Rik ENSMUST00000307623.1 1700121L16Rik (from geneSymbol) AK007232 uc334wxt.1 uc334wxt.1 
ENSMUST00000307627.1 Gm31447 ENSMUST00000307627.1 Gm31447 (from geneSymbol) uc334wxx.1 uc334wxx.1 
ENSMUST00000307629.1 ENSMUSG00000131727 ENSMUST00000307629.1 ENSMUSG00000131727 (from geneSymbol) uc334wxz.1 uc334wxz.1 
ENSMUST00000307633.1 Gm29458 ENSMUST00000307633.1 Gm29458 (from geneSymbol) uc334wyd.1 uc334wyd.1 
ENSMUST00000307660.1 ENSMUSG00000131728 ENSMUST00000307660.1 ENSMUSG00000131728 (from geneSymbol) KY467882 uc334wze.1 uc334wze.1 
ENSMUST00000307673.1 ENSMUSG00000131729 ENSMUST00000307673.1 ENSMUSG00000131729 (from geneSymbol) uc334wzr.1 uc334wzr.1 
ENSMUST00000307674.1 ENSMUSG00000131730 ENSMUST00000307674.1 ENSMUSG00000131730 (from geneSymbol) uc334wzs.1 uc334wzs.1 
ENSMUST00000307677.1 Gm12531 ENSMUST00000307677.1 Gm12531 (from geneSymbol) AK029633 uc334wzv.1 uc334wzv.1 
ENSMUST00000307687.1 Gm13990 ENSMUST00000307687.1 Gm13990 (from geneSymbol) AK054431 uc334xaf.1 uc334xaf.1 
ENSMUST00000307721.1 ENSMUSG00000131731 ENSMUST00000307721.1 ENSMUSG00000131731 (from geneSymbol) uc334xbn.1 uc334xbn.1 
ENSMUST00000307728.1 ENSMUSG00000131732 ENSMUST00000307728.1 ENSMUSG00000131732 (from geneSymbol) uc334xbu.1 uc334xbu.1 
ENSMUST00000307729.1 ENSMUSG00000131733 ENSMUST00000307729.1 ENSMUSG00000131733 (from geneSymbol) uc334xbv.1 uc334xbv.1 
ENSMUST00000307732.1 ENSMUSG00000131734 ENSMUST00000307732.1 ENSMUSG00000131734 (from geneSymbol) uc334xby.1 uc334xby.1 
ENSMUST00000307734.1 AI314278 ENSMUST00000307734.1 AI314278 (from geneSymbol) AK165495 uc334xca.1 uc334xca.1 
ENSMUST00000307745.1 ENSMUSG00000131735 ENSMUST00000307745.1 ENSMUSG00000131735 (from geneSymbol) uc334xcl.1 uc334xcl.1 
ENSMUST00000307747.1 ENSMUSG00000131736 ENSMUST00000307747.1 ENSMUSG00000131736 (from geneSymbol) uc334xcn.1 uc334xcn.1 
ENSMUST00000307749.1 ENSMUSG00000131737 ENSMUST00000307749.1 ENSMUSG00000131737 (from geneSymbol) uc334xcp.1 uc334xcp.1 
ENSMUST00000307750.1 ENSMUSG00000131738 ENSMUST00000307750.1 ENSMUSG00000131738 (from geneSymbol) uc334xcq.1 uc334xcq.1 
ENSMUST00000307757.1 ENSMUSG00000131740 ENSMUST00000307757.1 ENSMUSG00000131740 (from geneSymbol) uc334xcv.1 uc334xcv.1 
ENSMUST00000307758.1 ENSMUSG00000131741 ENSMUST00000307758.1 ENSMUSG00000131741 (from geneSymbol) uc334xcw.1 uc334xcw.1 
ENSMUST00000307760.1 ENSMUSG00000131742 ENSMUST00000307760.1 ENSMUSG00000131742 (from geneSymbol) uc334xcy.1 uc334xcy.1 
ENSMUST00000307761.1 ENSMUSG00000131743 ENSMUST00000307761.1 ENSMUSG00000131743 (from geneSymbol) uc334xcz.1 uc334xcz.1 
ENSMUST00000307765.1 ENSMUSG00000131744 ENSMUST00000307765.1 ENSMUSG00000131744 (from geneSymbol) uc334xdd.1 uc334xdd.1 
ENSMUST00000307771.1 ENSMUSG00000131745 ENSMUST00000307771.1 ENSMUSG00000131745 (from geneSymbol) uc334xdj.1 uc334xdj.1 
ENSMUST00000307772.1 ENSMUSG00000131746 ENSMUST00000307772.1 ENSMUSG00000131746 (from geneSymbol) uc334xdk.1 uc334xdk.1 
ENSMUST00000307773.1 ENSMUSG00000131747 ENSMUST00000307773.1 ENSMUSG00000131747 (from geneSymbol) uc334xdl.1 uc334xdl.1 
ENSMUST00000307783.1 ENSMUSG00000131748 ENSMUST00000307783.1 ENSMUSG00000131748 (from geneSymbol) uc334xdv.1 uc334xdv.1 
ENSMUST00000307784.1 ENSMUSG00000131749 ENSMUST00000307784.1 ENSMUSG00000131749 (from geneSymbol) uc334xdw.1 uc334xdw.1 
ENSMUST00000307786.1 ENSMUSG00000131750 ENSMUST00000307786.1 ENSMUSG00000131750 (from geneSymbol) uc334xdy.1 uc334xdy.1 
ENSMUST00000307788.1 ENSMUSG00000131751 ENSMUST00000307788.1 ENSMUSG00000131751 (from geneSymbol) uc334xea.1 uc334xea.1 
ENSMUST00000307789.1 Gm48168 ENSMUST00000307789.1 Gm48168 (from geneSymbol) uc334xeb.1 uc334xeb.1 
ENSMUST00000307793.1 ENSMUSG00000131752 ENSMUST00000307793.1 ENSMUSG00000131752 (from geneSymbol) uc334xef.1 uc334xef.1 
ENSMUST00000307794.1 ENSMUSG00000131753 ENSMUST00000307794.1 ENSMUSG00000131753 (from geneSymbol) uc334xeg.1 uc334xeg.1 
ENSMUST00000307800.1 ENSMUSG00000131754 ENSMUST00000307800.1 ENSMUSG00000131754 (from geneSymbol) uc334xem.1 uc334xem.1 
ENSMUST00000307801.1 Gm32567 ENSMUST00000307801.1 Gm32567 (from geneSymbol) uc334xen.1 uc334xen.1 
ENSMUST00000307808.1 ENSMUSG00000131755 ENSMUST00000307808.1 ENSMUSG00000131755 (from geneSymbol) uc334xeu.1 uc334xeu.1 
ENSMUST00000307809.1 ENSMUSG00000131756 ENSMUST00000307809.1 ENSMUSG00000131756 (from geneSymbol) uc334xev.1 uc334xev.1 
ENSMUST00000307812.1 1700026F02Rik ENSMUST00000307812.1 1700026F02Rik (from geneSymbol) AK006380 uc334xey.1 uc334xey.1 
ENSMUST00000307825.1 ENSMUSG00000131757 ENSMUST00000307825.1 ENSMUSG00000131757 (from geneSymbol) uc334xfl.1 uc334xfl.1 
ENSMUST00000307826.1 ENSMUSG00000131758 ENSMUST00000307826.1 ENSMUSG00000131758 (from geneSymbol) uc334xfm.1 uc334xfm.1 
ENSMUST00000307856.1 ENSMUSG00000131759 ENSMUST00000307856.1 ENSMUSG00000131759 (from geneSymbol) uc334xgq.1 uc334xgq.1 
ENSMUST00000307859.1 ENSMUSG00000131760 ENSMUST00000307859.1 ENSMUSG00000131760 (from geneSymbol) uc334xgt.1 uc334xgt.1 
ENSMUST00000307863.1 ENSMUSG00000131761 ENSMUST00000307863.1 ENSMUSG00000131761 (from geneSymbol) uc334xgx.1 uc334xgx.1 
ENSMUST00000307869.1 ENSMUSG00000131763 ENSMUST00000307869.1 ENSMUSG00000131763 (from geneSymbol) AK082597 uc334xha.1 uc334xha.1 
ENSMUST00000307870.1 Gm47732 ENSMUST00000307870.1 Gm47732 (from geneSymbol) uc334xhb.1 uc334xhb.1 
ENSMUST00000307874.1 ENSMUSG00000131764 ENSMUST00000307874.1 ENSMUSG00000131764 (from geneSymbol) uc334xhf.1 uc334xhf.1 
ENSMUST00000307875.1 ENSMUSG00000131765 ENSMUST00000307875.1 ENSMUSG00000131765 (from geneSymbol) uc334xhg.1 uc334xhg.1 
ENSMUST00000307878.1 Lincred1 ENSMUST00000307878.1 Lincred1 (from geneSymbol) JQ173109 uc334xhj.1 uc334xhj.1 
ENSMUST00000307926.1 Gm36535 ENSMUST00000307926.1 Gm36535 (from geneSymbol) uc334xiq.1 uc334xiq.1 
ENSMUST00000307939.1 ENSMUSG00000131767 ENSMUST00000307939.1 ENSMUSG00000131767 (from geneSymbol) uc334xjd.1 uc334xjd.1 
ENSMUST00000307940.1 ENSMUSG00000131768 ENSMUST00000307940.1 ENSMUSG00000131768 (from geneSymbol) uc334xje.1 uc334xje.1 
ENSMUST00000307950.1 D330050G23Rik ENSMUST00000307950.1 D330050G23Rik (from geneSymbol) AK084832 uc334xjo.1 uc334xjo.1 
ENSMUST00000308086.1 ENSMUSG00000131769 ENSMUST00000308086.1 ENSMUSG00000131769 (from geneSymbol) uc334xou.1 uc334xou.1 
ENSMUST00000308087.1 ENSMUSG00000131770 ENSMUST00000308087.1 ENSMUSG00000131770 (from geneSymbol) uc334xov.1 uc334xov.1 
ENSMUST00000308091.1 ENSMUSG00000131771 ENSMUST00000308091.1 ENSMUSG00000131771 (from geneSymbol) uc334xoz.1 uc334xoz.1 
ENSMUST00000308108.1 ENSMUSG00000131772 ENSMUST00000308108.1 ENSMUSG00000131772 (from geneSymbol) uc334xpq.1 uc334xpq.1 
ENSMUST00000308119.1 ENSMUSG00000131773 ENSMUST00000308119.1 ENSMUSG00000131773 (from geneSymbol) uc334xqb.1 uc334xqb.1 
ENSMUST00000308120.1 ENSMUSG00000131774 ENSMUST00000308120.1 ENSMUSG00000131774 (from geneSymbol) uc334xqc.1 uc334xqc.1 
ENSMUST00000308121.1 ENSMUSG00000131775 ENSMUST00000308121.1 ENSMUSG00000131775 (from geneSymbol) AK145422 uc334xqd.1 uc334xqd.1 
ENSMUST00000308152.1 ENSMUSG00000131776 ENSMUST00000308152.1 ENSMUSG00000131776 (from geneSymbol) uc334xri.1 uc334xri.1 
ENSMUST00000308153.1 ENSMUSG00000131777 ENSMUST00000308153.1 ENSMUSG00000131777 (from geneSymbol) uc334xrj.1 uc334xrj.1 
ENSMUST00000308154.1 ENSMUSG00000131778 ENSMUST00000308154.1 ENSMUSG00000131778 (from geneSymbol) uc334xrk.1 uc334xrk.1 
ENSMUST00000308163.1 ENSMUSG00000131779 ENSMUST00000308163.1 ENSMUSG00000131779 (from geneSymbol) uc334xrt.1 uc334xrt.1 
ENSMUST00000308164.1 ENSMUSG00000131780 ENSMUST00000308164.1 ENSMUSG00000131780 (from geneSymbol) uc334xru.1 uc334xru.1 
ENSMUST00000308165.1 ENSMUSG00000131781 ENSMUST00000308165.1 ENSMUSG00000131781 (from geneSymbol) uc334xrv.1 uc334xrv.1 
ENSMUST00000308166.1 Gm13546 ENSMUST00000308166.1 Gm13546 (from geneSymbol) AK041746 uc334xrw.1 uc334xrw.1 
ENSMUST00000308171.1 ENSMUSG00000131782 ENSMUST00000308171.1 ENSMUSG00000131782 (from geneSymbol) uc334xsb.1 uc334xsb.1 
ENSMUST00000308176.1 1700094M24Rik ENSMUST00000308176.1 1700094M24Rik (from geneSymbol) AK007072 uc334xsg.1 uc334xsg.1 
ENSMUST00000308194.1 Gm48170 ENSMUST00000308194.1 Gm48170 (from geneSymbol) uc334xsy.1 uc334xsy.1 
ENSMUST00000308203.1 Gm50028 ENSMUST00000308203.1 Gm50028 (from geneSymbol) uc334xth.1 uc334xth.1 
ENSMUST00000308204.1 ENSMUSG00000131783 ENSMUST00000308204.1 ENSMUSG00000131783 (from geneSymbol) uc334xti.1 uc334xti.1 
ENSMUST00000308216.1 Gm34623 ENSMUST00000308216.1 Gm34623 (from geneSymbol) uc334xtu.1 uc334xtu.1 
ENSMUST00000308242.1 ENSMUSG00000131784 ENSMUST00000308242.1 ENSMUSG00000131784 (from geneSymbol) uc334xuu.1 uc334xuu.1 
ENSMUST00000308245.1 ENSMUSG00000131785 ENSMUST00000308245.1 ENSMUSG00000131785 (from geneSymbol) uc334xux.1 uc334xux.1 
ENSMUST00000308246.1 ENSMUSG00000131786 ENSMUST00000308246.1 ENSMUSG00000131786 (from geneSymbol) uc334xuy.1 uc334xuy.1 
ENSMUST00000308247.1 ENSMUSG00000131787 ENSMUST00000308247.1 ENSMUSG00000131787 (from geneSymbol) uc334xuz.1 uc334xuz.1 
ENSMUST00000308249.1 ENSMUSG00000131788 ENSMUST00000308249.1 ENSMUSG00000131788 (from geneSymbol) uc334xvb.1 uc334xvb.1 
ENSMUST00000308250.1 ENSMUSG00000131789 ENSMUST00000308250.1 ENSMUSG00000131789 (from geneSymbol) uc334xvc.1 uc334xvc.1 
ENSMUST00000308254.1 ENSMUSG00000131790 ENSMUST00000308254.1 ENSMUSG00000131790 (from geneSymbol) uc334xvg.1 uc334xvg.1 
ENSMUST00000308266.1 ENSMUSG00000131791 ENSMUST00000308266.1 ENSMUSG00000131791 (from geneSymbol) uc334xvq.1 uc334xvq.1 
ENSMUST00000308268.1 ENSMUSG00000131792 ENSMUST00000308268.1 ENSMUSG00000131792 (from geneSymbol) uc334xvs.1 uc334xvs.1 
ENSMUST00000308269.1 ENSMUSG00000131793 ENSMUST00000308269.1 ENSMUSG00000131793 (from geneSymbol) uc334xvt.1 uc334xvt.1 
ENSMUST00000308270.1 ENSMUSG00000131794 ENSMUST00000308270.1 ENSMUSG00000131794 (from geneSymbol) uc334xvu.1 uc334xvu.1 
ENSMUST00000308271.1 9230111E07Rik ENSMUST00000308271.1 9230111E07Rik (from geneSymbol) KY467917 uc334xvv.1 uc334xvv.1 
ENSMUST00000308285.1 ENSMUSG00000131795 ENSMUST00000308285.1 ENSMUSG00000131795 (from geneSymbol) uc334xwj.1 uc334xwj.1 
ENSMUST00000308287.1 ENSMUSG00000131796 ENSMUST00000308287.1 ENSMUSG00000131796 (from geneSymbol) uc334xwl.1 uc334xwl.1 
ENSMUST00000308297.1 ENSMUSG00000131797 ENSMUST00000308297.1 ENSMUSG00000131797 (from geneSymbol) uc334xwv.1 uc334xwv.1 
ENSMUST00000308298.1 ENSMUSG00000131798 ENSMUST00000308298.1 ENSMUSG00000131798 (from geneSymbol) uc334xww.1 uc334xww.1 
ENSMUST00000308300.1 ENSMUSG00000131799 ENSMUST00000308300.1 ENSMUSG00000131799 (from geneSymbol) uc334xwy.1 uc334xwy.1 
ENSMUST00000308302.1 ENSMUSG00000131801 ENSMUST00000308302.1 ENSMUSG00000131801 (from geneSymbol) uc334xwz.1 uc334xwz.1 
ENSMUST00000308305.1 Gm35386 ENSMUST00000308305.1 Gm35386 (from geneSymbol) uc334xxc.1 uc334xxc.1 
ENSMUST00000308309.1 ENSMUSG00000131802 ENSMUST00000308309.1 ENSMUSG00000131802 (from geneSymbol) uc334xxg.1 uc334xxg.1 
ENSMUST00000308315.1 Hmgb4os ENSMUST00000308315.1 Hmgb4os (from geneSymbol) AK016051 uc334xxl.1 uc334xxl.1 
ENSMUST00000308317.1 ENSMUSG00000131803 ENSMUST00000308317.1 ENSMUSG00000131803 (from geneSymbol) uc334xxn.1 uc334xxn.1 
ENSMUST00000308320.1 ENSMUSG00000131804 ENSMUST00000308320.1 ENSMUSG00000131804 (from geneSymbol) uc334xxq.1 uc334xxq.1 
ENSMUST00000308321.1 ENSMUSG00000131805 ENSMUST00000308321.1 ENSMUSG00000131805 (from geneSymbol) uc334xxr.1 uc334xxr.1 
ENSMUST00000308322.1 ENSMUSG00000131806 ENSMUST00000308322.1 ENSMUSG00000131806 (from geneSymbol) uc334xxs.1 uc334xxs.1 
ENSMUST00000308324.1 Gm29340 ENSMUST00000308324.1 Gm29340 (from geneSymbol) uc334xxu.1 uc334xxu.1 
ENSMUST00000308331.1 ENSMUSG00000131807 ENSMUST00000308331.1 ENSMUSG00000131807 (from geneSymbol) uc334xyb.1 uc334xyb.1 
ENSMUST00000308339.1 ENSMUSG00000121355 ENSMUST00000308339.1 ENSMUSG00000121355 (from geneSymbol) uc334xyj.1 uc334xyj.1 
ENSMUST00000308342.1 ENSMUSG00000131808 ENSMUST00000308342.1 ENSMUSG00000131808 (from geneSymbol) uc334xym.1 uc334xym.1 
ENSMUST00000308343.1 ENSMUSG00000131809 ENSMUST00000308343.1 ENSMUSG00000131809 (from geneSymbol) uc334xyn.1 uc334xyn.1 
ENSMUST00000308344.1 ENSMUSG00000131810 ENSMUST00000308344.1 ENSMUSG00000131810 (from geneSymbol) uc334xyo.1 uc334xyo.1 
ENSMUST00000308345.1 ENSMUSG00000131811 ENSMUST00000308345.1 ENSMUSG00000131811 (from geneSymbol) uc334xyp.1 uc334xyp.1 
ENSMUST00000308347.1 ENSMUSG00000131812 ENSMUST00000308347.1 ENSMUSG00000131812 (from geneSymbol) uc334xyr.1 uc334xyr.1 
ENSMUST00000308357.1 Gm37323 ENSMUST00000308357.1 Gm37323 (from geneSymbol) uc334xzb.1 uc334xzb.1 
ENSMUST00000308403.1 ENSMUSG00000131813 ENSMUST00000308403.1 ENSMUSG00000131813 (from geneSymbol) uc334yav.1 uc334yav.1 
ENSMUST00000308404.1 ENSMUSG00000131814 ENSMUST00000308404.1 ENSMUSG00000131814 (from geneSymbol) uc334yaw.1 uc334yaw.1 
ENSMUST00000308406.1 ENSMUSG00000131815 ENSMUST00000308406.1 ENSMUSG00000131815 (from geneSymbol) uc334yay.1 uc334yay.1 
ENSMUST00000308408.1 ENSMUSG00000131816 ENSMUST00000308408.1 predicted gene 4371 (from RefSeq NR_028311.1) NR_028311 uc334yba.1 uc334yba.1 
ENSMUST00000308413.1 ENSMUSG00000131817 ENSMUST00000308413.1 ENSMUSG00000131817 (from geneSymbol) uc334ybf.1 uc334ybf.1 
ENSMUST00000308414.1 ENSMUSG00000131818 ENSMUST00000308414.1 ENSMUSG00000131818 (from geneSymbol) uc334ybg.1 uc334ybg.1 
ENSMUST00000308415.1 9930111H07Rik ENSMUST00000308415.1 9930111H07Rik (from geneSymbol) AK020686 uc334ybh.1 uc334ybh.1 
ENSMUST00000308467.1 ENSMUSG00000131819 ENSMUST00000308467.1 ENSMUSG00000131819 (from geneSymbol) uc334ydh.1 uc334ydh.1 
ENSMUST00000308479.1 ENSMUSG00000131820 ENSMUST00000308479.1 ENSMUSG00000131820 (from geneSymbol) uc334ydt.1 uc334ydt.1 
ENSMUST00000308490.1 ENSMUSG00000131821 ENSMUST00000308490.1 ENSMUSG00000131821 (from geneSymbol) uc334yee.1 uc334yee.1 
ENSMUST00000308491.1 ENSMUSG00000131822 ENSMUST00000308491.1 ENSMUSG00000131822 (from geneSymbol) uc334yef.1 uc334yef.1 
ENSMUST00000308502.1 ENSMUSG00000131823 ENSMUST00000308502.1 ENSMUSG00000131823 (from geneSymbol) uc334yeq.1 uc334yeq.1 
ENSMUST00000308507.1 ENSMUSG00000131824 ENSMUST00000308507.1 ENSMUSG00000131824 (from geneSymbol) uc334yev.1 uc334yev.1 
ENSMUST00000308508.1 ENSMUSG00000131825 ENSMUST00000308508.1 ENSMUSG00000131825 (from geneSymbol) uc334yew.1 uc334yew.1 
ENSMUST00000308509.1 ENSMUSG00000131826 ENSMUST00000308509.1 ENSMUSG00000131826 (from geneSymbol) uc334yex.1 uc334yex.1 
ENSMUST00000308510.1 ENSMUSG00000131827 ENSMUST00000308510.1 ENSMUSG00000131827 (from geneSymbol) uc334yey.1 uc334yey.1 
ENSMUST00000308511.1 ENSMUSG00000131828 ENSMUST00000308511.1 ENSMUSG00000131828 (from geneSymbol) uc334yez.1 uc334yez.1 
ENSMUST00000308512.1 ENSMUSG00000131829 ENSMUST00000308512.1 ENSMUSG00000131829 (from geneSymbol) uc334yfa.1 uc334yfa.1 
ENSMUST00000308516.1 Zmiz1os1 ENSMUST00000308516.1 Zmiz1os1 (from geneSymbol) AK086741 uc334yfe.1 uc334yfe.1 
ENSMUST00000308564.1 ENSMUSG00000131830 ENSMUST00000308564.1 ENSMUSG00000131830 (from geneSymbol) uc334yha.1 uc334yha.1 
ENSMUST00000308565.1 ENSMUSG00000131831 ENSMUST00000308565.1 ENSMUSG00000131831 (from geneSymbol) uc334yhb.1 uc334yhb.1 
ENSMUST00000308566.1 ENSMUSG00000131832 ENSMUST00000308566.1 ENSMUSG00000131832 (from geneSymbol) uc334yhc.1 uc334yhc.1 
ENSMUST00000308568.1 ENSMUSG00000131833 ENSMUST00000308568.1 ENSMUSG00000131833 (from geneSymbol) uc334yhe.1 uc334yhe.1 
ENSMUST00000308569.1 ENSMUSG00000131834 ENSMUST00000308569.1 ENSMUSG00000131834 (from geneSymbol) uc334yhf.1 uc334yhf.1 
ENSMUST00000308577.1 Gm12371 ENSMUST00000308577.1 Gm12371 (from geneSymbol) AK081400 uc334yhn.1 uc334yhn.1 
ENSMUST00000308587.1 Gm30541 ENSMUST00000308587.1 Gm30541 (from geneSymbol) uc334yhx.1 uc334yhx.1 
ENSMUST00000308599.1 Gm13842 ENSMUST00000308599.1 Gm13842 (from geneSymbol) KY468063 uc334yii.1 uc334yii.1 
ENSMUST00000308615.1 ENSMUSG00000131836 ENSMUST00000308615.1 ENSMUSG00000131836 (from geneSymbol) uc334yiy.1 uc334yiy.1 
ENSMUST00000308620.1 ENSMUSG00000131837 ENSMUST00000308620.1 ENSMUSG00000131837 (from geneSymbol) uc334yjd.1 uc334yjd.1 
ENSMUST00000308622.1 ENSMUSG00000131838 ENSMUST00000308622.1 ENSMUSG00000131838 (from geneSymbol) uc334yjf.1 uc334yjf.1 
ENSMUST00000308623.1 ENSMUSG00000131839 ENSMUST00000308623.1 ENSMUSG00000131839 (from geneSymbol) uc334yjg.1 uc334yjg.1 
ENSMUST00000308625.1 ENSMUSG00000131840 ENSMUST00000308625.1 ENSMUSG00000131840 (from geneSymbol) uc334yji.1 uc334yji.1 
ENSMUST00000308629.1 Gm19437 ENSMUST00000308629.1 Gm19437 (from geneSymbol) uc334yjm.1 uc334yjm.1 
ENSMUST00000308630.1 Gm49024 ENSMUST00000308630.1 Gm49024 (from geneSymbol) uc334yjn.1 uc334yjn.1 
ENSMUST00000308633.1 ENSMUSG00000131841 ENSMUST00000308633.1 ENSMUSG00000131841 (from geneSymbol) uc334yjq.1 uc334yjq.1 
ENSMUST00000308634.1 ENSMUSG00000131842 ENSMUST00000308634.1 ENSMUSG00000131842 (from geneSymbol) uc334yjr.1 uc334yjr.1 
ENSMUST00000308635.1 Gm34278 ENSMUST00000308635.1 Gm34278 (from geneSymbol) uc334yjs.1 uc334yjs.1 
ENSMUST00000308640.1 ENSMUSG00000131843 ENSMUST00000308640.1 ENSMUSG00000131843 (from geneSymbol) uc334yjx.1 uc334yjx.1 
ENSMUST00000308641.1 ENSMUSG00000131844 ENSMUST00000308641.1 ENSMUSG00000131844 (from geneSymbol) uc334yjy.1 uc334yjy.1 
ENSMUST00000308642.1 ENSMUSG00000131845 ENSMUST00000308642.1 ENSMUSG00000131845 (from geneSymbol) uc334yjz.1 uc334yjz.1 
ENSMUST00000308643.1 ENSMUSG00000131846 ENSMUST00000308643.1 ENSMUSG00000131846 (from geneSymbol) uc334yka.1 uc334yka.1 
ENSMUST00000308645.1 ENSMUSG00000131847 ENSMUST00000308645.1 ENSMUSG00000131847 (from geneSymbol) uc334ykc.1 uc334ykc.1 
ENSMUST00000308647.1 ENSMUSG00000131848 ENSMUST00000308647.1 ENSMUSG00000131848 (from geneSymbol) uc334yke.1 uc334yke.1 
ENSMUST00000308648.1 ENSMUSG00000131849 ENSMUST00000308648.1 ENSMUSG00000131849 (from geneSymbol) uc334ykf.1 uc334ykf.1 
ENSMUST00000308659.1 ENSMUSG00000131850 ENSMUST00000308659.1 ENSMUSG00000131850 (from geneSymbol) uc334ykq.1 uc334ykq.1 
ENSMUST00000308672.1 ENSMUSG00000131851 ENSMUST00000308672.1 ENSMUSG00000131851 (from geneSymbol) AK078011 uc334yld.1 uc334yld.1 
ENSMUST00000308682.1 Platr26 ENSMUST00000308682.1 Platr26 (from geneSymbol) AY512918 uc334yln.1 uc334yln.1 
ENSMUST00000308726.1 ENSMUSG00000131852 ENSMUST00000308726.1 ENSMUSG00000131852 (from geneSymbol) uc334ynf.1 uc334ynf.1 
ENSMUST00000308732.1 Gm49912 ENSMUST00000308732.1 Gm49912 (from geneSymbol) uc334ynl.1 uc334ynl.1 
ENSMUST00000308735.1 ENSMUSG00000131853 ENSMUST00000308735.1 ENSMUSG00000131853 (from geneSymbol) uc334yno.1 uc334yno.1 
ENSMUST00000308736.1 ENSMUSG00000131854 ENSMUST00000308736.1 ENSMUSG00000131854 (from geneSymbol) uc334ynp.1 uc334ynp.1 
ENSMUST00000308740.1 ENSMUSG00000131855 ENSMUST00000308740.1 ENSMUSG00000131855 (from geneSymbol) uc334ynt.1 uc334ynt.1 
ENSMUST00000308743.1 4930532G15Rik ENSMUST00000308743.1 4930532G15Rik (from geneSymbol) AK015943 uc334ynw.1 uc334ynw.1 
ENSMUST00000308763.1 ENSMUSG00000131856 ENSMUST00000308763.1 ENSMUSG00000131856 (from geneSymbol) uc334yoq.1 uc334yoq.1 
ENSMUST00000308764.1 ENSMUSG00000131857 ENSMUST00000308764.1 ENSMUSG00000131857 (from geneSymbol) uc334yor.1 uc334yor.1 
ENSMUST00000308766.1 BC049987 ENSMUST00000308766.1 BC049987 (from geneSymbol) BC042789 uc334yot.1 uc334yot.1 
ENSMUST00000308787.1 ENSMUSG00000131858 ENSMUST00000308787.1 ENSMUSG00000131858 (from geneSymbol) uc334ypo.1 uc334ypo.1 
ENSMUST00000308789.1 ENSMUSG00000131859 ENSMUST00000308789.1 ENSMUSG00000131859 (from geneSymbol) uc334ypq.1 uc334ypq.1 
ENSMUST00000308795.1 ENSMUSG00000131860 ENSMUST00000308795.1 ENSMUSG00000131860 (from geneSymbol) uc334ypw.1 uc334ypw.1 
ENSMUST00000308796.1 ENSMUSG00000131861 ENSMUST00000308796.1 ENSMUSG00000131861 (from geneSymbol) uc334ypx.1 uc334ypx.1 
ENSMUST00000308798.1 ENSMUSG00000131862 ENSMUST00000308798.1 ENSMUSG00000131862 (from geneSymbol) uc334ypz.1 uc334ypz.1 
ENSMUST00000308800.1 ENSMUSG00000131863 ENSMUST00000308800.1 ENSMUSG00000131863 (from geneSymbol) uc334yqb.1 uc334yqb.1 
ENSMUST00000308802.1 ENSMUSG00000131864 ENSMUST00000308802.1 ENSMUSG00000131864 (from geneSymbol) KY467688 uc334yqd.1 uc334yqd.1 
ENSMUST00000308809.1 ENSMUSG00000131865 ENSMUST00000308809.1 ENSMUSG00000131865 (from geneSymbol) uc334yqk.1 uc334yqk.1 
ENSMUST00000308811.1 ENSMUSG00000131867 ENSMUST00000308811.1 ENSMUSG00000131867 (from geneSymbol) uc334yql.1 uc334yql.1 
ENSMUST00000308813.1 ENSMUSG00000131868 ENSMUST00000308813.1 ENSMUSG00000131868 (from geneSymbol) AK006682 uc334yqn.1 uc334yqn.1 
ENSMUST00000308815.1 Gm48941 ENSMUST00000308815.1 Gm48941 (from geneSymbol) uc334yqp.1 uc334yqp.1 
ENSMUST00000308819.1 ENSMUSG00000131869 ENSMUST00000308819.1 ENSMUSG00000131869 (from geneSymbol) uc334yqt.1 uc334yqt.1 
ENSMUST00000308820.1 ENSMUSG00000131870 ENSMUST00000308820.1 ENSMUSG00000131870 (from geneSymbol) uc334yqu.1 uc334yqu.1 
ENSMUST00000308821.1 ENSMUSG00000131871 ENSMUST00000308821.1 ENSMUSG00000131871 (from geneSymbol) uc334yqv.1 uc334yqv.1 
ENSMUST00000308822.1 ENSMUSG00000131872 ENSMUST00000308822.1 ENSMUSG00000131872 (from geneSymbol) uc334yqw.1 uc334yqw.1 
ENSMUST00000308828.1 ENSMUSG00000131873 ENSMUST00000308828.1 ENSMUSG00000131873 (from geneSymbol) uc334yrc.1 uc334yrc.1 
ENSMUST00000308829.1 ENSMUSG00000131874 ENSMUST00000308829.1 ENSMUSG00000131874 (from geneSymbol) uc334yrd.1 uc334yrd.1 
ENSMUST00000308835.1 ENSMUSG00000131875 ENSMUST00000308835.1 ENSMUSG00000131875 (from geneSymbol) uc334yrj.1 uc334yrj.1 
ENSMUST00000308840.1 Gm9926 ENSMUST00000308840.1 Gm9926 (from geneSymbol) AK033454 uc334yro.1 uc334yro.1 
ENSMUST00000308851.1 ENSMUSG00000131876 ENSMUST00000308851.1 ENSMUSG00000131876 (from geneSymbol) uc334yrz.1 uc334yrz.1 
ENSMUST00000308852.1 ENSMUSG00000131877 ENSMUST00000308852.1 ENSMUSG00000131877 (from geneSymbol) uc334ysa.1 uc334ysa.1 
ENSMUST00000308853.1 ENSMUSG00000131878 ENSMUST00000308853.1 ENSMUSG00000131878 (from geneSymbol) uc334ysb.1 uc334ysb.1 
ENSMUST00000308854.1 ENSMUSG00000131879 ENSMUST00000308854.1 ENSMUSG00000131879 (from geneSymbol) uc334ysc.1 uc334ysc.1 
ENSMUST00000308856.1 Gm44066 ENSMUST00000308856.1 Gm44066 (from geneSymbol) uc334yse.1 uc334yse.1 
ENSMUST00000308858.1 ENSMUSG00000131880 ENSMUST00000308858.1 ENSMUSG00000131880 (from geneSymbol) uc334ysg.1 uc334ysg.1 
ENSMUST00000308859.1 ENSMUSG00000131881 ENSMUST00000308859.1 ENSMUSG00000131881 (from geneSymbol) uc334ysh.1 uc334ysh.1 
ENSMUST00000308860.1 ENSMUSG00000131882 ENSMUST00000308860.1 ENSMUSG00000131882 (from geneSymbol) uc334ysi.1 uc334ysi.1 
ENSMUST00000308862.1 ENSMUSG00000131883 ENSMUST00000308862.1 ENSMUSG00000131883 (from geneSymbol) uc334ysk.1 uc334ysk.1 
ENSMUST00000308864.1 ENSMUSG00000131884 ENSMUST00000308864.1 ENSMUSG00000131884 (from geneSymbol) uc334ysm.1 uc334ysm.1 
ENSMUST00000308872.1 AI606473 ENSMUST00000308872.1 AI606473 (from geneSymbol) AK142074 uc334ysu.1 uc334ysu.1 
ENSMUST00000308874.1 ENSMUSG00000131885 ENSMUST00000308874.1 ENSMUSG00000131885 (from geneSymbol) uc334ysw.1 uc334ysw.1 
ENSMUST00000308901.1 ENSMUSG00000131886 ENSMUST00000308901.1 ENSMUSG00000131886 (from geneSymbol) uc334ytx.1 uc334ytx.1 
ENSMUST00000308904.1 ENSMUSG00000131887 ENSMUST00000308904.1 ENSMUSG00000131887 (from geneSymbol) uc334yua.1 uc334yua.1 
ENSMUST00000308909.1 ENSMUSG00000131888 ENSMUST00000308909.1 ENSMUSG00000131888 (from geneSymbol) uc334yuf.1 uc334yuf.1 
ENSMUST00000308910.1 ENSMUSG00000131889 ENSMUST00000308910.1 ENSMUSG00000131889 (from geneSymbol) uc334yug.1 uc334yug.1 
ENSMUST00000308911.1 ENSMUSG00000131890 ENSMUST00000308911.1 ENSMUSG00000131890 (from geneSymbol) uc334yuh.1 uc334yuh.1 
ENSMUST00000308912.1 ENSMUSG00000131891 ENSMUST00000308912.1 ENSMUSG00000131891 (from geneSymbol) uc334yui.1 uc334yui.1 
ENSMUST00000308918.1 ENSMUSG00000131892 ENSMUST00000308918.1 ENSMUSG00000131892 (from geneSymbol) uc334yuo.1 uc334yuo.1 
ENSMUST00000308932.1 ENSMUSG00000131893 ENSMUST00000308932.1 ENSMUSG00000131893 (from geneSymbol) uc334yvc.1 uc334yvc.1 
ENSMUST00000308933.1 ENSMUSG00000131894 ENSMUST00000308933.1 ENSMUSG00000131894 (from geneSymbol) LF200272 uc334yvd.1 uc334yvd.1 
ENSMUST00000308955.1 Gm53065 ENSMUST00000308955.1 Gm53065 (from geneSymbol) BC051519 uc334yvz.1 uc334yvz.1 
ENSMUST00000309007.1 ENSMUSG00000131895 ENSMUST00000309007.1 ENSMUSG00000131895 (from geneSymbol) uc334yxz.1 uc334yxz.1 
ENSMUST00000309024.1 ENSMUSG00000131896 ENSMUST00000309024.1 ENSMUSG00000131896 (from geneSymbol) uc334yyq.1 uc334yyq.1 
ENSMUST00000309025.1 ENSMUSG00000131897 ENSMUST00000309025.1 ENSMUSG00000131897 (from geneSymbol) uc334yyr.1 uc334yyr.1 
ENSMUST00000309027.1 ENSMUSG00000131898 ENSMUST00000309027.1 ENSMUSG00000131898 (from geneSymbol) uc334yyt.1 uc334yyt.1 
ENSMUST00000309030.1 ENSMUSG00000131899 ENSMUST00000309030.1 ENSMUSG00000131899 (from geneSymbol) uc334yyw.1 uc334yyw.1 
ENSMUST00000309040.1 Gm38997 ENSMUST00000309040.1 Gm38997 (from geneSymbol) uc334yzg.1 uc334yzg.1 
ENSMUST00000309044.1 Gm28050 ENSMUST00000309044.1 Gm28050 (from geneSymbol) AK138287 uc334yzk.1 uc334yzk.1 
ENSMUST00000309056.1 ENSMUSG00000131900 ENSMUST00000309056.1 ENSMUSG00000131900 (from geneSymbol) uc334yzw.1 uc334yzw.1 
ENSMUST00000309057.1 ENSMUSG00000131901 ENSMUST00000309057.1 ENSMUSG00000131901 (from geneSymbol) uc334yzx.1 uc334yzx.1 
ENSMUST00000309058.1 ENSMUSG00000131902 ENSMUST00000309058.1 ENSMUSG00000131902 (from geneSymbol) uc334yzy.1 uc334yzy.1 
ENSMUST00000309059.1 ENSMUSG00000131903 ENSMUST00000309059.1 ENSMUSG00000131903 (from geneSymbol) DQ543601 uc334yzz.1 uc334yzz.1 
ENSMUST00000309060.1 ENSMUSG00000131904 ENSMUST00000309060.1 ENSMUSG00000131904 (from geneSymbol) uc334zaa.1 uc334zaa.1 
ENSMUST00000309064.1 ENSMUSG00000131905 ENSMUST00000309064.1 ENSMUSG00000131905 (from geneSymbol) uc334zae.1 uc334zae.1 
ENSMUST00000309065.1 ENSMUSG00000131906 ENSMUST00000309065.1 ENSMUSG00000131906 (from geneSymbol) uc334zaf.1 uc334zaf.1 
ENSMUST00000309068.1 ENSMUSG00000131907 ENSMUST00000309068.1 ENSMUSG00000131907 (from geneSymbol) uc334zai.1 uc334zai.1 
ENSMUST00000309069.1 ENSMUSG00000131908 ENSMUST00000309069.1 ENSMUSG00000131908 (from geneSymbol) uc334zaj.1 uc334zaj.1 
ENSMUST00000309072.1 ENSMUSG00000131909 ENSMUST00000309072.1 ENSMUSG00000131909 (from geneSymbol) uc334zam.1 uc334zam.1 
ENSMUST00000309080.1 2810403D21Rik ENSMUST00000309080.1 2810403D21Rik (from geneSymbol) KY468259 uc334zau.1 uc334zau.1 
ENSMUST00000309145.1 ENSMUSG00000131910 ENSMUST00000309145.1 ENSMUSG00000131910 (from geneSymbol) uc334zdh.1 uc334zdh.1 
ENSMUST00000309187.1 4933417C20Rik ENSMUST00000309187.1 RIKEN cDNA 4933417C20 gene (from RefSeq NR_190035.1) NR_190035 uc334zew.1 uc334zew.1 
ENSMUST00000309188.1 ENSMUSG00000131912 ENSMUST00000309188.1 ENSMUSG00000131912 (from geneSymbol) uc334zex.1 uc334zex.1 
ENSMUST00000309189.1 ENSMUSG00000131913 ENSMUST00000309189.1 ENSMUSG00000131913 (from geneSymbol) uc334zey.1 uc334zey.1 
ENSMUST00000309190.1 ENSMUSG00000131914 ENSMUST00000309190.1 ENSMUSG00000131914 (from geneSymbol) uc334zez.1 uc334zez.1 
ENSMUST00000309191.1 ENSMUSG00000131915 ENSMUST00000309191.1 ENSMUSG00000131915 (from geneSymbol) uc334zfa.1 uc334zfa.1 
ENSMUST00000309192.1 A530083I20Rik ENSMUST00000309192.1 A530083I20Rik (from geneSymbol) AK041109 uc334zfb.1 uc334zfb.1 
ENSMUST00000309203.1 Gm49249 ENSMUST00000309203.1 Gm49249 (from geneSymbol) uc334zfm.1 uc334zfm.1 
ENSMUST00000309209.1 ENSMUSG00000131916 ENSMUST00000309209.1 ENSMUSG00000131916 (from geneSymbol) uc334zfs.1 uc334zfs.1 
ENSMUST00000309210.1 ENSMUSG00000131917 ENSMUST00000309210.1 ENSMUSG00000131917 (from geneSymbol) uc334zft.1 uc334zft.1 
ENSMUST00000309211.1 ENSMUSG00000131918 ENSMUST00000309211.1 ENSMUSG00000131918 (from geneSymbol) uc334zfu.1 uc334zfu.1 
ENSMUST00000309212.1 ENSMUSG00000131919 ENSMUST00000309212.1 ENSMUSG00000131919 (from geneSymbol) uc334zfv.1 uc334zfv.1 
ENSMUST00000309213.1 ENSMUSG00000131920 ENSMUST00000309213.1 ENSMUSG00000131920 (from geneSymbol) uc334zfw.1 uc334zfw.1 
ENSMUST00000309214.1 ENSMUSG00000131921 ENSMUST00000309214.1 ENSMUSG00000131921 (from geneSymbol) uc334zfx.1 uc334zfx.1 
ENSMUST00000309218.1 Gm11734 ENSMUST00000309218.1 Gm11734 (from geneSymbol) uc334zgb.1 uc334zgb.1 
ENSMUST00000309251.1 ENSMUSG00000131922 ENSMUST00000309251.1 ENSMUSG00000131922 (from geneSymbol) uc334zhi.1 uc334zhi.1 
ENSMUST00000309252.1 ENSMUSG00000131923 ENSMUST00000309252.1 ENSMUSG00000131923 (from geneSymbol) uc334zhj.1 uc334zhj.1 
ENSMUST00000309255.1 ENSMUSG00000131924 ENSMUST00000309255.1 ENSMUSG00000131924 (from geneSymbol) uc334zhm.1 uc334zhm.1 
ENSMUST00000309256.1 ENSMUSG00000131925 ENSMUST00000309256.1 ENSMUSG00000131925 (from geneSymbol) uc334zhn.1 uc334zhn.1 
ENSMUST00000309257.1 Gm19261 ENSMUST00000309257.1 Gm19261 (from geneSymbol) uc334zho.1 uc334zho.1 
ENSMUST00000309259.1 Gm57112 ENSMUST00000309259.1 Gm57112 (from geneSymbol) uc334zhq.1 uc334zhq.1 
ENSMUST00000309260.1 ENSMUSG00000131926 ENSMUST00000309260.1 ENSMUSG00000131926 (from geneSymbol) uc334zhr.1 uc334zhr.1 
ENSMUST00000309261.1 Gm56535 ENSMUST00000309261.1 Gm56535 (from geneSymbol) uc334zhs.1 uc334zhs.1 
ENSMUST00000309270.1 ENSMUSG00000131927 ENSMUST00000309270.1 ENSMUSG00000131927 (from geneSymbol) uc334zib.1 uc334zib.1 
ENSMUST00000309271.1 Gm26639 ENSMUST00000309271.1 Gm26639 (from geneSymbol) uc334zic.1 uc334zic.1 
ENSMUST00000309273.1 ENSMUSG00000131928 ENSMUST00000309273.1 ENSMUSG00000131928 (from geneSymbol) uc334zie.1 uc334zie.1 
ENSMUST00000309274.1 ENSMUSG00000131929 ENSMUST00000309274.1 ENSMUSG00000131929 (from geneSymbol) uc334zif.1 uc334zif.1 
ENSMUST00000309275.1 ENSMUSG00000131930 ENSMUST00000309275.1 ENSMUSG00000131930 (from geneSymbol) uc334zig.1 uc334zig.1 
ENSMUST00000309280.1 ENSMUSG00000131931 ENSMUST00000309280.1 ENSMUSG00000131931 (from geneSymbol) uc334zil.1 uc334zil.1 
ENSMUST00000309291.1 ENSMUSG00000131932 ENSMUST00000309291.1 ENSMUSG00000131932 (from geneSymbol) uc334ziw.1 uc334ziw.1 
ENSMUST00000309292.1 Apol7d ENSMUST00000309292.1 Apol7d (from geneSymbol) uc334zix.1 uc334zix.1 
ENSMUST00000309330.1 ENSMUSG00000131933 ENSMUST00000309330.1 ENSMUSG00000131933 (from geneSymbol) uc334zkj.1 uc334zkj.1 
ENSMUST00000309333.1 ENSMUSG00000131934 ENSMUST00000309333.1 ENSMUSG00000131934 (from geneSymbol) uc334zkm.1 uc334zkm.1 
ENSMUST00000309334.1 ENSMUSG00000131935 ENSMUST00000309334.1 ENSMUSG00000131935 (from geneSymbol) uc334zkn.1 uc334zkn.1 
ENSMUST00000309335.1 ENSMUSG00000131936 ENSMUST00000309335.1 ENSMUSG00000131936 (from geneSymbol) AK016790 uc334zko.1 uc334zko.1 
ENSMUST00000309336.1 ENSMUSG00000131937 ENSMUST00000309336.1 ENSMUSG00000131937 (from geneSymbol) uc334zkp.1 uc334zkp.1 
ENSMUST00000309339.1 ENSMUSG00000131938 ENSMUST00000309339.1 ENSMUSG00000131938 (from geneSymbol) uc334zks.1 uc334zks.1 
ENSMUST00000309342.1 ENSMUSG00000131939 ENSMUST00000309342.1 ENSMUSG00000131939 (from geneSymbol) uc334zkv.1 uc334zkv.1 
ENSMUST00000309368.1 Gm17747 ENSMUST00000309368.1 Gm17747 (from geneSymbol) AK146230 uc334zlv.1 uc334zlv.1 
ENSMUST00000309372.1 Gm31121 ENSMUST00000309372.1 Gm31121 (from geneSymbol) AK139864 uc334zlz.1 uc334zlz.1 
ENSMUST00000309398.1 ENSMUSG00000131940 ENSMUST00000309398.1 ENSMUSG00000131940 (from geneSymbol) uc334zmz.1 uc334zmz.1 
ENSMUST00000309399.1 ENSMUSG00000131941 ENSMUST00000309399.1 ENSMUSG00000131941 (from geneSymbol) DQ700433 uc334zna.1 uc334zna.1 
ENSMUST00000309407.1 ENSMUSG00000131942 ENSMUST00000309407.1 ENSMUSG00000131942 (from geneSymbol) uc334zni.1 uc334zni.1 
ENSMUST00000309412.1 ENSMUSG00000131943 ENSMUST00000309412.1 ENSMUSG00000131943 (from geneSymbol) uc334znn.1 uc334znn.1 
ENSMUST00000309414.1 ENSMUSG00000131944 ENSMUST00000309414.1 ENSMUSG00000131944 (from geneSymbol) LF201645 uc334znp.1 uc334znp.1 
ENSMUST00000309415.1 ENSMUSG00000131945 ENSMUST00000309415.1 ENSMUSG00000131945 (from geneSymbol) LF200561 uc334znq.1 uc334znq.1 
ENSMUST00000309416.1 ENSMUSG00000131946 ENSMUST00000309416.1 ENSMUSG00000131946 (from geneSymbol) uc334znr.1 uc334znr.1 
ENSMUST00000309419.1 2010204K13Rik ENSMUST00000309419.1 2010204K13Rik (from geneSymbol) AK077356 uc334znu.1 uc334znu.1 
ENSMUST00000309433.1 ENSMUSG00000131947 ENSMUST00000309433.1 ENSMUSG00000131947 (from geneSymbol) uc334zoi.1 uc334zoi.1 
ENSMUST00000309434.1 ENSMUSG00000131948 ENSMUST00000309434.1 ENSMUSG00000131948 (from geneSymbol) uc334zoj.1 uc334zoj.1 
ENSMUST00000309436.1 ENSMUSG00000131949 ENSMUST00000309436.1 ENSMUSG00000131949 (from geneSymbol) uc334zol.1 uc334zol.1 
ENSMUST00000309437.1 ENSMUSG00000131950 ENSMUST00000309437.1 ENSMUSG00000131950 (from geneSymbol) uc334zom.1 uc334zom.1 
ENSMUST00000309438.1 ENSMUSG00000131951 ENSMUST00000309438.1 ENSMUSG00000131951 (from geneSymbol) uc334zon.1 uc334zon.1 
ENSMUST00000309451.1 ENSMUSG00000131953 ENSMUST00000309451.1 ENSMUSG00000131953 (from geneSymbol) KY467666 uc334zoz.1 uc334zoz.1 
ENSMUST00000309453.1 ENSMUSG00000131954 ENSMUST00000309453.1 ENSMUSG00000131954 (from geneSymbol) uc334zpb.1 uc334zpb.1 
ENSMUST00000309454.1 Gm46280 ENSMUST00000309454.1 Gm46280 (from geneSymbol) uc334zpc.1 uc334zpc.1 
ENSMUST00000309468.1 ENSMUSG00000131955 ENSMUST00000309468.1 ENSMUSG00000131955 (from geneSymbol) uc334zpq.1 uc334zpq.1 
ENSMUST00000309471.1 Gm39321 ENSMUST00000309471.1 Gm39321 (from geneSymbol) AK136151 uc334zpt.1 uc334zpt.1 
ENSMUST00000309473.1 ENSMUSG00000131956 ENSMUST00000309473.1 ENSMUSG00000131956 (from geneSymbol) uc334zpv.1 uc334zpv.1 
ENSMUST00000309475.1 ENSMUSG00000131957 ENSMUST00000309475.1 ENSMUSG00000131957 (from geneSymbol) uc334zpx.1 uc334zpx.1 
ENSMUST00000309477.1 ENSMUSG00000131958 ENSMUST00000309477.1 ENSMUSG00000131958 (from geneSymbol) uc334zpz.1 uc334zpz.1 
ENSMUST00000309479.1 ENSMUSG00000131959 ENSMUST00000309479.1 ENSMUSG00000131959 (from geneSymbol) uc334zqb.1 uc334zqb.1 
ENSMUST00000309481.1 ENSMUSG00000131960 ENSMUST00000309481.1 ENSMUSG00000131960 (from geneSymbol) uc334zqd.1 uc334zqd.1 
ENSMUST00000309484.1 ENSMUSG00000131961 ENSMUST00000309484.1 ENSMUSG00000131961 (from geneSymbol) uc334zqg.1 uc334zqg.1 
ENSMUST00000309485.1 ENSMUSG00000131962 ENSMUST00000309485.1 ENSMUSG00000131962 (from geneSymbol) uc334zqh.1 uc334zqh.1 
ENSMUST00000309500.1 Gm12348 ENSMUST00000309500.1 Gm12348 (from geneSymbol) AK158747 uc334zqw.1 uc334zqw.1 
ENSMUST00000309502.1 ENSMUSG00000131963 ENSMUST00000309502.1 ENSMUSG00000131963 (from geneSymbol) uc334zqy.1 uc334zqy.1 
ENSMUST00000309505.1 ENSMUSG00000131964 ENSMUST00000309505.1 ENSMUSG00000131964 (from geneSymbol) AK019781 uc334zrb.1 uc334zrb.1 
ENSMUST00000309514.1 ENSMUSG00000131965 ENSMUST00000309514.1 ENSMUSG00000131965 (from geneSymbol) uc334zrk.1 uc334zrk.1 
ENSMUST00000309518.1 ENSMUSG00000131966 ENSMUST00000309518.1 ENSMUSG00000131966 (from geneSymbol) uc334zro.1 uc334zro.1 
ENSMUST00000309525.1 Gm39167 ENSMUST00000309525.1 Gm39167 (from geneSymbol) uc334zrv.1 uc334zrv.1 
ENSMUST00000309527.1 Gm13524 ENSMUST00000309527.1 Gm13524 (from geneSymbol) uc334zrx.1 uc334zrx.1 
ENSMUST00000309529.1 ENSMUSG00000131967 ENSMUST00000309529.1 ENSMUSG00000131967 (from geneSymbol) uc334zrz.1 uc334zrz.1 
ENSMUST00000309532.1 ENSMUSG00000131968 ENSMUST00000309532.1 ENSMUSG00000131968 (from geneSymbol) uc334zsc.1 uc334zsc.1 
ENSMUST00000309540.1 ENSMUSG00000131970 ENSMUST00000309540.1 ENSMUSG00000131970 (from geneSymbol) uc334zsh.1 uc334zsh.1 
ENSMUST00000309541.1 ENSMUSG00000131971 ENSMUST00000309541.1 ENSMUSG00000131971 (from geneSymbol) uc334zsi.1 uc334zsi.1 
ENSMUST00000309542.1 ENSMUSG00000131972 ENSMUST00000309542.1 ENSMUSG00000131972 (from geneSymbol) uc334zsj.1 uc334zsj.1 
ENSMUST00000309543.1 ENSMUSG00000131973 ENSMUST00000309543.1 ENSMUSG00000131973 (from geneSymbol) uc334zsk.1 uc334zsk.1 
ENSMUST00000309544.1 ENSMUSG00000131974 ENSMUST00000309544.1 ENSMUSG00000131974 (from geneSymbol) uc334zsl.1 uc334zsl.1 
ENSMUST00000309545.1 ENSMUSG00000131975 ENSMUST00000309545.1 ENSMUSG00000131975 (from geneSymbol) uc334zsm.1 uc334zsm.1 
ENSMUST00000309555.1 ENSMUSG00000131976 ENSMUST00000309555.1 ENSMUSG00000131976 (from geneSymbol) uc334zsw.1 uc334zsw.1 
ENSMUST00000309556.1 ENSMUSG00000131977 ENSMUST00000309556.1 ENSMUSG00000131977 (from geneSymbol) uc334zsx.1 uc334zsx.1 
ENSMUST00000309557.1 Gm41113 ENSMUST00000309557.1 Gm41113 (from geneSymbol) uc334zsy.1 uc334zsy.1 
ENSMUST00000309559.1 ENSMUSG00000131979 ENSMUST00000309559.1 ENSMUSG00000131979 (from geneSymbol) uc334zta.1 uc334zta.1 
ENSMUST00000309560.1 ENSMUSG00000131980 ENSMUST00000309560.1 ENSMUSG00000131980 (from geneSymbol) uc334ztb.1 uc334ztb.1 
ENSMUST00000309561.1 ENSMUSG00000131981 ENSMUST00000309561.1 ENSMUSG00000131981 (from geneSymbol) uc334ztc.1 uc334ztc.1 
ENSMUST00000309562.1 ENSMUSG00000131982 ENSMUST00000309562.1 ENSMUSG00000131982 (from geneSymbol) AK039756 uc334ztd.1 uc334ztd.1 
ENSMUST00000309563.1 ENSMUSG00000131983 ENSMUST00000309563.1 ENSMUSG00000131983 (from geneSymbol) uc334zte.1 uc334zte.1 
ENSMUST00000309564.1 ENSMUSG00000131984 ENSMUST00000309564.1 ENSMUSG00000131984 (from geneSymbol) uc334ztf.1 uc334ztf.1 
ENSMUST00000309565.1 ENSMUSG00000131985 ENSMUST00000309565.1 ENSMUSG00000131985 (from geneSymbol) uc334ztg.1 uc334ztg.1 
ENSMUST00000309574.1 ENSMUSG00000131986 ENSMUST00000309574.1 ENSMUSG00000131986 (from geneSymbol) uc334ztp.1 uc334ztp.1 
ENSMUST00000309576.1 ENSMUSG00000131987 ENSMUST00000309576.1 ENSMUSG00000131987 (from geneSymbol) uc334ztr.1 uc334ztr.1 
ENSMUST00000309577.1 Gm57101 ENSMUST00000309577.1 Gm57101 (from geneSymbol) uc334zts.1 uc334zts.1 
ENSMUST00000309578.1 ENSMUSG00000131988 ENSMUST00000309578.1 ENSMUSG00000131988 (from geneSymbol) uc334ztt.1 uc334ztt.1 
ENSMUST00000309579.1 ENSMUSG00000131989 ENSMUST00000309579.1 ENSMUSG00000131989 (from geneSymbol) uc334ztu.1 uc334ztu.1 
ENSMUST00000309580.1 ENSMUSG00000131990 ENSMUST00000309580.1 ENSMUSG00000131990 (from geneSymbol) uc334ztv.1 uc334ztv.1 
ENSMUST00000309581.1 ENSMUSG00000131991 ENSMUST00000309581.1 ENSMUSG00000131991 (from geneSymbol) uc334ztw.1 uc334ztw.1 
ENSMUST00000309583.1 ENSMUSG00000131992 ENSMUST00000309583.1 ENSMUSG00000131992 (from geneSymbol) uc334zty.1 uc334zty.1 
ENSMUST00000309584.1 ENSMUSG00000131993 ENSMUST00000309584.1 ENSMUSG00000131993 (from geneSymbol) AK016241 uc334ztz.1 uc334ztz.1 
ENSMUST00000309585.1 ENSMUSG00000131994 ENSMUST00000309585.1 ENSMUSG00000131994 (from geneSymbol) uc334zua.1 uc334zua.1 
ENSMUST00000309586.1 ENSMUSG00000131995 ENSMUST00000309586.1 ENSMUSG00000131995 (from geneSymbol) uc334zub.1 uc334zub.1 
ENSMUST00000309587.1 ENSMUSG00000131996 ENSMUST00000309587.1 ENSMUSG00000131996 (from geneSymbol) uc334zuc.1 uc334zuc.1 
ENSMUST00000309589.1 Prox1os ENSMUST00000309589.1 Prox1os (from geneSymbol) AK142161 uc334zue.1 uc334zue.1 
ENSMUST00000309682.1 ENSMUSG00000131997 ENSMUST00000309682.1 ENSMUSG00000131997 (from geneSymbol) uc334zxt.1 uc334zxt.1 
ENSMUST00000309685.1 ENSMUSG00000131998 ENSMUST00000309685.1 ENSMUSG00000131998 (from geneSymbol) uc334zxw.1 uc334zxw.1 
ENSMUST00000309686.1 ENSMUSG00000131999 ENSMUST00000309686.1 ENSMUSG00000131999 (from geneSymbol) uc334zxx.1 uc334zxx.1 
ENSMUST00000309687.1 ENSMUSG00000132000 ENSMUST00000309687.1 ENSMUSG00000132000 (from geneSymbol) uc334zxy.1 uc334zxy.1 
ENSMUST00000309688.1 Gm9920 ENSMUST00000309688.1 Gm9920 (from geneSymbol) AK081722 uc334zxz.1 uc334zxz.1 
ENSMUST00000309689.1 ENSMUSG00000132001 ENSMUST00000309689.1 ENSMUSG00000132001 (from geneSymbol) uc334zya.1 uc334zya.1 
ENSMUST00000309691.1 ENSMUSG00000132002 ENSMUST00000309691.1 ENSMUSG00000132002 (from geneSymbol) uc334zyc.1 uc334zyc.1 
ENSMUST00000309692.1 ENSMUSG00000132003 ENSMUST00000309692.1 ENSMUSG00000132003 (from geneSymbol) uc334zyd.1 uc334zyd.1 
ENSMUST00000309694.1 ENSMUSG00000132004 ENSMUST00000309694.1 ENSMUSG00000132004 (from geneSymbol) uc334zyf.1 uc334zyf.1 
ENSMUST00000309695.1 ENSMUSG00000132005 ENSMUST00000309695.1 ENSMUSG00000132005 (from geneSymbol) uc334zyg.1 uc334zyg.1 
ENSMUST00000309698.1 ENSMUSG00000132007 ENSMUST00000309698.1 ENSMUSG00000132007 (from geneSymbol) uc334zyi.1 uc334zyi.1 
ENSMUST00000309699.1 ENSMUSG00000132008 ENSMUST00000309699.1 ENSMUSG00000132008 (from geneSymbol) uc334zyj.1 uc334zyj.1 
ENSMUST00000309700.1 ENSMUSG00000132009 ENSMUST00000309700.1 ENSMUSG00000132009 (from geneSymbol) uc334zyk.1 uc334zyk.1 
ENSMUST00000309701.1 ENSMUSG00000132010 ENSMUST00000309701.1 ENSMUSG00000132010 (from geneSymbol) uc334zyl.1 uc334zyl.1 
ENSMUST00000309705.1 ENSMUSG00000132011 ENSMUST00000309705.1 ENSMUSG00000132011 (from geneSymbol) uc334zyp.1 uc334zyp.1 
ENSMUST00000309710.1 Gm12522 ENSMUST00000309710.1 Gm12522 (from geneSymbol) AK090264 uc334zyu.1 uc334zyu.1 
ENSMUST00000309720.1 ENSMUSG00000132012 ENSMUST00000309720.1 ENSMUSG00000132012 (from geneSymbol) uc334zze.1 uc334zze.1 
ENSMUST00000309722.1 ENSMUSG00000132013 ENSMUST00000309722.1 ENSMUSG00000132013 (from geneSymbol) uc334zzg.1 uc334zzg.1 
ENSMUST00000309723.1 ENSMUSG00000132014 ENSMUST00000309723.1 ENSMUSG00000132014 (from geneSymbol) uc334zzh.1 uc334zzh.1 
ENSMUST00000309727.1 ENSMUSG00000132016 ENSMUST00000309727.1 ENSMUSG00000132016 (from geneSymbol) uc334zzi.1 uc334zzi.1 
ENSMUST00000309728.1 ENSMUSG00000132017 ENSMUST00000309728.1 ENSMUSG00000132017 (from geneSymbol) uc334zzj.1 uc334zzj.1 
ENSMUST00000309729.1 ENSMUSG00000132018 ENSMUST00000309729.1 ENSMUSG00000132018 (from geneSymbol) uc334zzk.1 uc334zzk.1 
ENSMUST00000309732.1 ENSMUSG00000132019 ENSMUST00000309732.1 ENSMUSG00000132019 (from geneSymbol) uc334zzn.1 uc334zzn.1 
ENSMUST00000309734.1 ENSMUSG00000132020 ENSMUST00000309734.1 ENSMUSG00000132020 (from geneSymbol) uc334zzp.1 uc334zzp.1 
ENSMUST00000309741.1 ENSMUSG00000132021 ENSMUST00000309741.1 ENSMUSG00000132021 (from geneSymbol) uc334zzw.1 uc334zzw.1 
ENSMUST00000309744.1 ENSMUSG00000132022 ENSMUST00000309744.1 ENSMUSG00000132022 (from geneSymbol) uc334zzz.1 uc334zzz.1 
ENSMUST00000309746.1 ENSMUSG00000132023 ENSMUST00000309746.1 ENSMUSG00000132023 (from geneSymbol) uc335aab.1 uc335aab.1 
ENSMUST00000309750.1 ENSMUSG00000132024 ENSMUST00000309750.1 ENSMUSG00000132024 (from geneSymbol) AK178033 uc335aaf.1 uc335aaf.1 
ENSMUST00000309753.1 ENSMUSG00000132025 ENSMUST00000309753.1 ENSMUSG00000132025 (from geneSymbol) uc335aai.1 uc335aai.1 
ENSMUST00000309754.1 ENSMUSG00000132026 ENSMUST00000309754.1 ENSMUSG00000132026 (from geneSymbol) uc335aaj.1 uc335aaj.1 
ENSMUST00000309761.1 ENSMUSG00000132027 ENSMUST00000309761.1 ENSMUSG00000132027 (from geneSymbol) uc335aaq.1 uc335aaq.1 
ENSMUST00000309763.1 ENSMUSG00000132028 ENSMUST00000309763.1 ENSMUSG00000132028 (from geneSymbol) uc335aas.1 uc335aas.1 
ENSMUST00000309764.1 Gm46515 ENSMUST00000309764.1 Gm46515 (from geneSymbol) uc335aat.1 uc335aat.1 
ENSMUST00000309776.1 ENSMUSG00000132029 ENSMUST00000309776.1 ENSMUSG00000132029 (from geneSymbol) uc335abf.1 uc335abf.1 
ENSMUST00000309781.1 ENSMUSG00000132030 ENSMUST00000309781.1 ENSMUSG00000132030 (from geneSymbol) uc335abk.1 uc335abk.1 
ENSMUST00000309784.1 ENSMUSG00000132031 ENSMUST00000309784.1 ENSMUSG00000132031 (from geneSymbol) uc335abn.1 uc335abn.1 
ENSMUST00000309785.1 Gm48843 ENSMUST00000309785.1 Gm48843 (from geneSymbol) uc335abo.1 uc335abo.1 
ENSMUST00000309787.1 ENSMUSG00000132032 ENSMUST00000309787.1 ENSMUSG00000132032 (from geneSymbol) uc335abq.1 uc335abq.1 
ENSMUST00000309788.1 ENSMUSG00000132033 ENSMUST00000309788.1 ENSMUSG00000132033 (from geneSymbol) uc335abr.1 uc335abr.1 
ENSMUST00000309789.1 ENSMUSG00000132034 ENSMUST00000309789.1 ENSMUSG00000132034 (from geneSymbol) uc335abs.1 uc335abs.1 
ENSMUST00000309790.1 ENSMUSG00000132035 ENSMUST00000309790.1 ENSMUSG00000132035 (from geneSymbol) uc335abt.1 uc335abt.1 
ENSMUST00000309791.1 ENSMUSG00000132036 ENSMUST00000309791.1 ENSMUSG00000132036 (from geneSymbol) uc335abu.1 uc335abu.1 
ENSMUST00000309793.1 ENSMUSG00000132037 ENSMUST00000309793.1 ENSMUSG00000132037 (from geneSymbol) uc335abw.1 uc335abw.1 
ENSMUST00000309794.1 ENSMUSG00000132038 ENSMUST00000309794.1 ENSMUSG00000132038 (from geneSymbol) uc335abx.1 uc335abx.1 
ENSMUST00000309797.1 ENSMUSG00000132039 ENSMUST00000309797.1 ENSMUSG00000132039 (from geneSymbol) uc335aca.1 uc335aca.1 
ENSMUST00000309802.1 ENSMUSG00000132040 ENSMUST00000309802.1 ENSMUSG00000132040 (from geneSymbol) uc335acf.1 uc335acf.1 
ENSMUST00000309803.1 ENSMUSG00000132041 ENSMUST00000309803.1 ENSMUSG00000132041 (from geneSymbol) uc335acg.1 uc335acg.1 
ENSMUST00000309804.1 Runx2os3 ENSMUST00000309804.1 Runx2os3 (from geneSymbol) uc335ach.1 uc335ach.1 
ENSMUST00000309807.1 9130230N09Rik ENSMUST00000309807.1 9130230N09Rik (from geneSymbol) uc335ack.1 uc335ack.1 
ENSMUST00000309809.1 Gm49779 ENSMUST00000309809.1 Gm49779 (from geneSymbol) uc335acm.1 uc335acm.1 
ENSMUST00000309811.1 ENSMUSG00000132042 ENSMUST00000309811.1 ENSMUSG00000132042 (from geneSymbol) uc335aco.1 uc335aco.1 
ENSMUST00000309812.1 ENSMUSG00000132043 ENSMUST00000309812.1 ENSMUSG00000132043 (from geneSymbol) uc335acp.1 uc335acp.1 
ENSMUST00000309813.1 ENSMUSG00000132044 ENSMUST00000309813.1 ENSMUSG00000132044 (from geneSymbol) uc335acq.1 uc335acq.1 
ENSMUST00000309815.1 ENSMUSG00000132045 ENSMUST00000309815.1 ENSMUSG00000132045 (from geneSymbol) uc335acs.1 uc335acs.1 
ENSMUST00000309816.1 ENSMUSG00000132046 ENSMUST00000309816.1 ENSMUSG00000132046 (from geneSymbol) uc335act.1 uc335act.1 
ENSMUST00000309821.1 ENSMUSG00000132047 ENSMUST00000309821.1 ENSMUSG00000132047 (from geneSymbol) KY468103 uc335acy.1 uc335acy.1 
ENSMUST00000309857.1 ENSMUSG00000132048 ENSMUST00000309857.1 ENSMUSG00000132048 (from geneSymbol) uc335aei.1 uc335aei.1 
ENSMUST00000309859.1 ENSMUSG00000132049 ENSMUST00000309859.1 ENSMUSG00000132049 (from geneSymbol) uc335aek.1 uc335aek.1 
ENSMUST00000309861.1 ENSMUSG00000132050 ENSMUST00000309861.1 ENSMUSG00000132050 (from geneSymbol) uc335aem.1 uc335aem.1 
ENSMUST00000309862.1 4930465K09Rik ENSMUST00000309862.1 4930465K09Rik (from geneSymbol) uc335aen.1 uc335aen.1 
ENSMUST00000309864.1 ENSMUSG00000132051 ENSMUST00000309864.1 ENSMUSG00000132051 (from geneSymbol) uc335aep.1 uc335aep.1 
ENSMUST00000309868.1 ENSMUSG00000132052 ENSMUST00000309868.1 ENSMUSG00000132052 (from geneSymbol) uc335aet.1 uc335aet.1 
ENSMUST00000309871.1 4930588K23Rik ENSMUST00000309871.1 4930588K23Rik (from geneSymbol) AK133126 uc335aew.1 uc335aew.1 
ENSMUST00000309888.1 ENSMUSG00000132053 ENSMUST00000309888.1 ENSMUSG00000132053 (from geneSymbol) uc335afn.1 uc335afn.1 
ENSMUST00000309889.1 Gm47289 ENSMUST00000309889.1 Gm47289 (from geneSymbol) uc335afo.1 uc335afo.1 
ENSMUST00000309891.1 Gm33351 ENSMUST00000309891.1 Gm33351 (from geneSymbol) uc335afq.1 uc335afq.1 
ENSMUST00000309894.1 ENSMUSG00000132054 ENSMUST00000309894.1 ENSMUSG00000132054 (from geneSymbol) uc335aft.1 uc335aft.1 
ENSMUST00000309897.1 Gm13324 ENSMUST00000309897.1 Gm13324 (from geneSymbol) uc335afw.1 uc335afw.1 
ENSMUST00000309898.1 ENSMUSG00000132055 ENSMUST00000309898.1 ENSMUSG00000132055 (from geneSymbol) uc335afx.1 uc335afx.1 
ENSMUST00000309900.1 ENSMUSG00000132056 ENSMUST00000309900.1 ENSMUSG00000132056 (from geneSymbol) LF201330 uc335afz.1 uc335afz.1 
ENSMUST00000309902.1 ENSMUSG00000132057 ENSMUST00000309902.1 ENSMUSG00000132057 (from geneSymbol) uc335agb.1 uc335agb.1 
ENSMUST00000309905.1 ENSMUSG00000132058 ENSMUST00000309905.1 ENSMUSG00000132058 (from geneSymbol) uc335age.1 uc335age.1 
ENSMUST00000309907.1 ENSMUSG00000132059 ENSMUST00000309907.1 ENSMUSG00000132059 (from geneSymbol) AK016433 uc335agg.1 uc335agg.1 
ENSMUST00000309909.1 ENSMUSG00000132060 ENSMUST00000309909.1 ENSMUSG00000132060 (from geneSymbol) uc335agi.1 uc335agi.1 
ENSMUST00000309910.1 ENSMUSG00000132061 ENSMUST00000309910.1 ENSMUSG00000132061 (from geneSymbol) uc335agj.1 uc335agj.1 
ENSMUST00000309911.1 2610316D01Rik ENSMUST00000309911.1 2610316D01Rik (from geneSymbol) AK012035 uc335agk.1 uc335agk.1 
ENSMUST00000309960.1 ENSMUSG00000132062 ENSMUST00000309960.1 ENSMUSG00000132062 (from geneSymbol) uc335aih.1 uc335aih.1 
ENSMUST00000309961.1 ENSMUSG00000132063 ENSMUST00000309961.1 ENSMUSG00000132063 (from geneSymbol) uc335aii.1 uc335aii.1 
ENSMUST00000309962.1 ENSMUSG00000132064 ENSMUST00000309962.1 ENSMUSG00000132064 (from geneSymbol) uc335aij.1 uc335aij.1 
ENSMUST00000309967.1 ENSMUSG00000132065 ENSMUST00000309967.1 ENSMUSG00000132065 (from geneSymbol) AK140580 uc335aio.1 uc335aio.1 
ENSMUST00000309971.1 4930405J17Rik ENSMUST00000309971.1 4930405J17Rik (from geneSymbol) AK015099 uc335ais.1 uc335ais.1 
ENSMUST00000309976.1 ENSMUSG00000132066 ENSMUST00000309976.1 ENSMUSG00000132066 (from geneSymbol) uc335aix.1 uc335aix.1 
ENSMUST00000309985.1 ENSMUSG00000132067 ENSMUST00000309985.1 ENSMUSG00000132067 (from geneSymbol) uc335ajg.1 uc335ajg.1 
ENSMUST00000309986.1 ENSMUSG00000132068 ENSMUST00000309986.1 ENSMUSG00000132068 (from geneSymbol) uc335ajh.1 uc335ajh.1 
ENSMUST00000309987.1 ENSMUSG00000132069 ENSMUST00000309987.1 ENSMUSG00000132069 (from geneSymbol) uc335aji.1 uc335aji.1 
ENSMUST00000309989.1 ENSMUSG00000132070 ENSMUST00000309989.1 ENSMUSG00000132070 (from geneSymbol) uc335ajk.1 uc335ajk.1 
ENSMUST00000309992.1 ENSMUSG00000132071 ENSMUST00000309992.1 ENSMUSG00000132071 (from geneSymbol) uc335ajn.1 uc335ajn.1 
ENSMUST00000309998.1 Gm57280 ENSMUST00000309998.1 Gm57280 (from geneSymbol) uc335ajt.1 uc335ajt.1 
ENSMUST00000310021.1 ENSMUSG00000132072 ENSMUST00000310021.1 ENSMUSG00000132072 (from geneSymbol) uc335akq.1 uc335akq.1 
ENSMUST00000310023.1 ENSMUSG00000132073 ENSMUST00000310023.1 ENSMUSG00000132073 (from geneSymbol) uc335aks.1 uc335aks.1 
ENSMUST00000310025.1 ENSMUSG00000132074 ENSMUST00000310025.1 ENSMUSG00000132074 (from geneSymbol) uc335aku.1 uc335aku.1 
ENSMUST00000310026.1 ENSMUSG00000132075 ENSMUST00000310026.1 ENSMUSG00000132075 (from geneSymbol) uc335akv.1 uc335akv.1 
ENSMUST00000310027.1 Gm12018 ENSMUST00000310027.1 Gm12018 (from geneSymbol) AK077028 uc335akw.1 uc335akw.1 
ENSMUST00000310032.1 ENSMUSG00000132076 ENSMUST00000310032.1 ENSMUSG00000132076 (from geneSymbol) LF198469 uc335alb.1 uc335alb.1 
ENSMUST00000310033.1 Gm49890 ENSMUST00000310033.1 predicted gene, 49890, transcript variant 1 (from RefSeq NR_132734.1) NR_132734 uc335alc.1 uc335alc.1 
ENSMUST00000310034.1 ENSMUSG00000132077 ENSMUST00000310034.1 ENSMUSG00000132077 (from geneSymbol) uc335ald.1 uc335ald.1 
ENSMUST00000310043.1 ENSMUSG00000132078 ENSMUST00000310043.1 ENSMUSG00000132078 (from geneSymbol) uc335alm.1 uc335alm.1 
ENSMUST00000310044.1 ENSMUSG00000132079 ENSMUST00000310044.1 ENSMUSG00000132079 (from geneSymbol) uc335aln.1 uc335aln.1 
ENSMUST00000310045.1 ENSMUSG00000132080 ENSMUST00000310045.1 ENSMUSG00000132080 (from geneSymbol) uc335alo.1 uc335alo.1 
ENSMUST00000310046.1 ENSMUSG00000132081 ENSMUST00000310046.1 ENSMUSG00000132081 (from geneSymbol) uc335alp.1 uc335alp.1 
ENSMUST00000310047.1 ENSMUSG00000132082 ENSMUST00000310047.1 ENSMUSG00000132082 (from geneSymbol) uc335alq.1 uc335alq.1 
ENSMUST00000310048.1 ENSMUSG00000132083 ENSMUST00000310048.1 ENSMUSG00000132083 (from geneSymbol) uc335alr.1 uc335alr.1 
ENSMUST00000310049.1 ENSMUSG00000121731 ENSMUST00000310049.1 ENSMUSG00000121731 (from geneSymbol) uc335als.1 uc335als.1 
ENSMUST00000310052.1 ENSMUSG00000132084 ENSMUST00000310052.1 ENSMUSG00000132084 (from geneSymbol) uc335alv.1 uc335alv.1 
ENSMUST00000310053.1 ENSMUSG00000132085 ENSMUST00000310053.1 ENSMUSG00000132085 (from geneSymbol) uc335alw.1 uc335alw.1 
ENSMUST00000310054.1 A230056P14Rik ENSMUST00000310054.1 A230056P14Rik (from geneSymbol) AK140288 uc335alx.1 uc335alx.1 
ENSMUST00000310064.1 1700041C23Rik ENSMUST00000310064.1 1700041C23Rik (from geneSymbol) AK006669 uc335amh.1 uc335amh.1 
ENSMUST00000310073.1 ENSMUSG00000132086 ENSMUST00000310073.1 ENSMUSG00000132086 (from geneSymbol) uc335amq.1 uc335amq.1 
ENSMUST00000310074.1 ENSMUSG00000132087 ENSMUST00000310074.1 ENSMUSG00000132087 (from geneSymbol) uc335amr.1 uc335amr.1 
ENSMUST00000310075.1 ENSMUSG00000132088 ENSMUST00000310075.1 ENSMUSG00000132088 (from geneSymbol) uc335ams.1 uc335ams.1 
ENSMUST00000310078.1 ENSMUSG00000132089 ENSMUST00000310078.1 ENSMUSG00000132089 (from geneSymbol) uc335amv.1 uc335amv.1 
ENSMUST00000310080.1 ENSMUSG00000132090 ENSMUST00000310080.1 ENSMUSG00000132090 (from geneSymbol) uc335amx.1 uc335amx.1 
ENSMUST00000310090.1 ENSMUSG00000132091 ENSMUST00000310090.1 ENSMUSG00000132091 (from geneSymbol) uc335anh.1 uc335anh.1 
ENSMUST00000310093.1 ENSMUSG00000132092 ENSMUST00000310093.1 ENSMUSG00000132092 (from geneSymbol) uc335ank.1 uc335ank.1 
ENSMUST00000310095.1 ENSMUSG00000132093 ENSMUST00000310095.1 ENSMUSG00000132093 (from geneSymbol) uc335anm.1 uc335anm.1 
ENSMUST00000310096.1 ENSMUSG00000132094 ENSMUST00000310096.1 ENSMUSG00000132094 (from geneSymbol) uc335ann.1 uc335ann.1 
ENSMUST00000310099.1 ENSMUSG00000132095 ENSMUST00000310099.1 ENSMUSG00000132095 (from geneSymbol) uc335anq.1 uc335anq.1 
ENSMUST00000310100.1 ENSMUSG00000132096 ENSMUST00000310100.1 ENSMUSG00000132096 (from geneSymbol) uc335anr.1 uc335anr.1 
ENSMUST00000310101.1 Gm32934 ENSMUST00000310101.1 predicted gene, 32934 (from RefSeq NR_175333.1) NR_175333 uc335ans.1 uc335ans.1 
ENSMUST00000310104.1 ENSMUSG00000132098 ENSMUST00000310104.1 ENSMUSG00000132098 (from geneSymbol) uc335anu.1 uc335anu.1 
ENSMUST00000310107.1 ENSMUSG00000132099 ENSMUST00000310107.1 ENSMUSG00000132099 (from geneSymbol) uc335anx.1 uc335anx.1 
ENSMUST00000310109.1 ENSMUSG00000132100 ENSMUST00000310109.1 ENSMUSG00000132100 (from geneSymbol) uc335anz.1 uc335anz.1 
ENSMUST00000310110.1 Gm57361 ENSMUST00000310110.1 Gm57361 (from geneSymbol) uc335aoa.1 uc335aoa.1 
ENSMUST00000310121.1 ENSMUSG00000132101 ENSMUST00000310121.1 ENSMUSG00000132101 (from geneSymbol) uc335aoj.1 uc335aoj.1 
ENSMUST00000310122.1 1700027H10Rik ENSMUST00000310122.1 1700027H10Rik (from geneSymbol) AK006417 uc335aok.1 uc335aok.1 
ENSMUST00000310130.1 ENSMUSG00000132102 ENSMUST00000310130.1 ENSMUSG00000132102 (from geneSymbol) uc335aos.1 uc335aos.1 
ENSMUST00000310131.1 ENSMUSG00000132103 ENSMUST00000310131.1 ENSMUSG00000132103 (from geneSymbol) uc335aot.1 uc335aot.1 
ENSMUST00000310132.1 ENSMUSG00000132104 ENSMUST00000310132.1 ENSMUSG00000132104 (from geneSymbol) uc335aou.1 uc335aou.1 
ENSMUST00000310134.1 A830021F12Rik ENSMUST00000310134.1 A830021F12Rik (from geneSymbol) AK043696 uc335aow.1 uc335aow.1 
ENSMUST00000310136.1 A830021M18Rik ENSMUST00000310136.1 A830021M18Rik (from geneSymbol) AK043703 uc335aoy.1 uc335aoy.1 
ENSMUST00000310143.1 ENSMUSG00000132105 ENSMUST00000310143.1 ENSMUSG00000132105 (from geneSymbol) uc335apf.1 uc335apf.1 
ENSMUST00000310144.1 ENSMUSG00000132106 ENSMUST00000310144.1 ENSMUSG00000132106 (from geneSymbol) uc335apg.1 uc335apg.1 
ENSMUST00000310145.1 ENSMUSG00000132107 ENSMUST00000310145.1 ENSMUSG00000132107 (from geneSymbol) uc335aph.1 uc335aph.1 
ENSMUST00000310146.1 ENSMUSG00000132108 ENSMUST00000310146.1 ENSMUSG00000132108 (from geneSymbol) uc335api.1 uc335api.1 
ENSMUST00000310147.1 ENSMUSG00000132109 ENSMUST00000310147.1 ENSMUSG00000132109 (from geneSymbol) uc335apj.1 uc335apj.1 
ENSMUST00000310148.1 ENSMUSG00000132110 ENSMUST00000310148.1 ENSMUSG00000132110 (from geneSymbol) uc335apk.1 uc335apk.1 
ENSMUST00000310159.1 ENSMUSG00000132111 ENSMUST00000310159.1 ENSMUSG00000132111 (from geneSymbol) AK131792 uc335apv.1 uc335apv.1 
ENSMUST00000310165.1 ENSMUSG00000132112 ENSMUST00000310165.1 ENSMUSG00000132112 (from geneSymbol) uc335aqb.1 uc335aqb.1 
ENSMUST00000310174.1 ENSMUSG00000132113 ENSMUST00000310174.1 ENSMUSG00000132113 (from geneSymbol) uc335aqk.1 uc335aqk.1 
ENSMUST00000310175.1 ENSMUSG00000132114 ENSMUST00000310175.1 ENSMUSG00000132114 (from geneSymbol) uc335aql.1 uc335aql.1 
ENSMUST00000310178.1 ENSMUSG00000132115 ENSMUST00000310178.1 ENSMUSG00000132115 (from geneSymbol) uc335aqo.1 uc335aqo.1 
ENSMUST00000310184.1 ENSMUSG00000132116 ENSMUST00000310184.1 ENSMUSG00000132116 (from geneSymbol) uc335aqu.1 uc335aqu.1 
ENSMUST00000310199.1 ENSMUSG00000132117 ENSMUST00000310199.1 ENSMUSG00000132117 (from geneSymbol) uc335arj.1 uc335arj.1 
ENSMUST00000310203.1 Gm49327 ENSMUST00000310203.1 predicted gene 9222, transcript variant 13 (from RefSeq NR_168605.1) NR_168605 uc335arn.1 uc335arn.1 
ENSMUST00000310226.1 ENSMUSG00000132118 ENSMUST00000310226.1 ENSMUSG00000132118 (from geneSymbol) uc335ask.1 uc335ask.1 
ENSMUST00000310228.1 ENSMUSG00000132119 ENSMUST00000310228.1 ENSMUSG00000132119 (from geneSymbol) uc335asm.1 uc335asm.1 
ENSMUST00000310229.1 ENSMUSG00000132120 ENSMUST00000310229.1 ENSMUSG00000132120 (from geneSymbol) uc335asn.1 uc335asn.1 
ENSMUST00000310233.1 ENSMUSG00000132121 ENSMUST00000310233.1 ENSMUSG00000132121 (from geneSymbol) uc335asr.1 uc335asr.1 
ENSMUST00000310240.1 D830024N08Rik ENSMUST00000310240.1 D830024N08Rik (from geneSymbol) AK085891 uc335asy.1 uc335asy.1 
ENSMUST00000310253.1 ENSMUSG00000132122 ENSMUST00000310253.1 ENSMUSG00000132122 (from geneSymbol) uc335atl.1 uc335atl.1 
ENSMUST00000310260.1 Gm14061 ENSMUST00000310260.1 Gm14061 (from geneSymbol) AK138226 uc335atr.1 uc335atr.1 
ENSMUST00000310264.1 ENSMUSG00000132123 ENSMUST00000310264.1 ENSMUSG00000132123 (from geneSymbol) uc335atv.1 uc335atv.1 
ENSMUST00000310272.1 ENSMUSG00000132124 ENSMUST00000310272.1 ENSMUSG00000132124 (from geneSymbol) uc335aud.1 uc335aud.1 
ENSMUST00000310278.1 ENSMUSG00000132125 ENSMUST00000310278.1 ENSMUSG00000132125 (from geneSymbol) uc335auj.1 uc335auj.1 
ENSMUST00000310279.1 ENSMUSG00000132126 ENSMUST00000310279.1 ENSMUSG00000132126 (from geneSymbol) uc335auk.1 uc335auk.1 
ENSMUST00000310280.1 ENSMUSG00000132127 ENSMUST00000310280.1 ENSMUSG00000132127 (from geneSymbol) uc335aul.1 uc335aul.1 
ENSMUST00000310281.1 ENSMUSG00000132128 ENSMUST00000310281.1 ENSMUSG00000132128 (from geneSymbol) uc335aum.1 uc335aum.1 
ENSMUST00000310283.1 ENSMUSG00000132129 ENSMUST00000310283.1 ENSMUSG00000132129 (from geneSymbol) uc335auo.1 uc335auo.1 
ENSMUST00000310284.1 ENSMUSG00000132130 ENSMUST00000310284.1 ENSMUSG00000132130 (from geneSymbol) uc335aup.1 uc335aup.1 
ENSMUST00000310285.1 ENSMUSG00000132131 ENSMUST00000310285.1 ENSMUSG00000132131 (from geneSymbol) uc335auq.1 uc335auq.1 
ENSMUST00000310286.1 ENSMUSG00000132132 ENSMUST00000310286.1 ENSMUSG00000132132 (from geneSymbol) uc335aur.1 uc335aur.1 
ENSMUST00000310291.1 ENSMUSG00000132133 ENSMUST00000310291.1 ENSMUSG00000132133 (from geneSymbol) uc335auw.1 uc335auw.1 
ENSMUST00000310296.1 Gm32098 ENSMUST00000310296.1 Gm32098 (from geneSymbol) uc335avb.1 uc335avb.1 
ENSMUST00000310312.1 C030037D09Rik ENSMUST00000310312.1 C030037D09Rik (from geneSymbol) AK021127 uc335avq.1 uc335avq.1 
ENSMUST00000310340.1 ENSMUSG00000132134 ENSMUST00000310340.1 ENSMUSG00000132134 (from geneSymbol) uc335aws.1 uc335aws.1 
ENSMUST00000310342.1 ENSMUSG00000132135 ENSMUST00000310342.1 ENSMUSG00000132135 (from geneSymbol) uc335awu.1 uc335awu.1 
ENSMUST00000310347.1 ENSMUSG00000132136 ENSMUST00000310347.1 ENSMUSG00000132136 (from geneSymbol) uc335awz.1 uc335awz.1 
ENSMUST00000310351.1 ENSMUSG00000132137 ENSMUST00000310351.1 ENSMUSG00000132137 (from geneSymbol) uc335axd.1 uc335axd.1 
ENSMUST00000310355.1 ENSMUSG00000132138 ENSMUST00000310355.1 ENSMUSG00000132138 (from geneSymbol) AK006385 uc335axh.1 uc335axh.1 
ENSMUST00000310360.1 D830026I12Rik ENSMUST00000310360.1 D830026I12Rik (from geneSymbol) AK052888 uc335axm.1 uc335axm.1 
ENSMUST00000310379.1 ENSMUSG00000132139 ENSMUST00000310379.1 ENSMUSG00000132139 (from geneSymbol) uc335ayf.1 uc335ayf.1 
ENSMUST00000310388.1 ENSMUSG00000132140 ENSMUST00000310388.1 ENSMUSG00000132140 (from geneSymbol) uc335ayo.1 uc335ayo.1 
ENSMUST00000310392.1 ENSMUSG00000132141 ENSMUST00000310392.1 ENSMUSG00000132141 (from geneSymbol) uc335ays.1 uc335ays.1 
ENSMUST00000310407.1 ENSMUSG00000132142 ENSMUST00000310407.1 ENSMUSG00000132142 (from geneSymbol) uc335azh.1 uc335azh.1 
ENSMUST00000310408.1 ENSMUSG00000132143 ENSMUST00000310408.1 ENSMUSG00000132143 (from geneSymbol) uc335azi.1 uc335azi.1 
ENSMUST00000310409.1 Gm10385 ENSMUST00000310409.1 Gm10385 (from geneSymbol) AK144597 uc335azj.1 uc335azj.1 
ENSMUST00000310414.1 ENSMUSG00000132145 ENSMUST00000310414.1 ENSMUSG00000132145 (from geneSymbol) uc335azo.1 uc335azo.1 
ENSMUST00000310415.1 ENSMUSG00000132144 ENSMUST00000310415.1 ENSMUSG00000132144 (from geneSymbol) uc335azp.1 uc335azp.1 
ENSMUST00000310418.1 ENSMUSG00000132146 ENSMUST00000310418.1 ENSMUSG00000132146 (from geneSymbol) uc335azs.1 uc335azs.1 
ENSMUST00000310419.1 ENSMUSG00000132147 ENSMUST00000310419.1 ENSMUSG00000132147 (from geneSymbol) uc335azt.1 uc335azt.1 
ENSMUST00000310423.1 ENSMUSG00000132148 ENSMUST00000310423.1 ENSMUSG00000132148 (from geneSymbol) uc335azx.1 uc335azx.1 
ENSMUST00000310433.1 ENSMUSG00000132149 ENSMUST00000310433.1 ENSMUSG00000132149 (from geneSymbol) uc335bah.1 uc335bah.1 
ENSMUST00000310434.1 ENSMUSG00000132150 ENSMUST00000310434.1 ENSMUSG00000132150 (from geneSymbol) uc335bai.1 uc335bai.1 
ENSMUST00000310435.1 ENSMUSG00000132151 ENSMUST00000310435.1 ENSMUSG00000132151 (from geneSymbol) uc335baj.1 uc335baj.1 
ENSMUST00000310436.1 ENSMUSG00000132152 ENSMUST00000310436.1 ENSMUSG00000132152 (from geneSymbol) uc335bak.1 uc335bak.1 
ENSMUST00000310440.1 ENSMUSG00000132153 ENSMUST00000310440.1 ENSMUSG00000132153 (from geneSymbol) uc335bao.1 uc335bao.1 
ENSMUST00000310442.1 2810032G03Rik ENSMUST00000310442.1 2810032G03Rik (from geneSymbol) AK012851 uc335baq.1 uc335baq.1 
ENSMUST00000310453.1 ENSMUSG00000132154 ENSMUST00000310453.1 ENSMUSG00000132154 (from geneSymbol) uc335bbb.1 uc335bbb.1 
ENSMUST00000310455.1 ENSMUSG00000132155 ENSMUST00000310455.1 ENSMUSG00000132155 (from geneSymbol) uc335bbd.1 uc335bbd.1 
ENSMUST00000310456.1 Gm40977 ENSMUST00000310456.1 Gm40977 (from geneSymbol) uc335bbe.1 uc335bbe.1 
ENSMUST00000310458.1 ENSMUSG00000132156 ENSMUST00000310458.1 ENSMUSG00000132156 (from geneSymbol) uc335bbg.1 uc335bbg.1 
ENSMUST00000310459.1 ENSMUSG00000132157 ENSMUST00000310459.1 ENSMUSG00000132157 (from geneSymbol) uc335bbh.1 uc335bbh.1 
ENSMUST00000310461.1 ENSMUSG00000132158 ENSMUST00000310461.1 ENSMUSG00000132158 (from geneSymbol) uc335bbj.1 uc335bbj.1 
ENSMUST00000310464.1 ENSMUSG00000132159 ENSMUST00000310464.1 ENSMUSG00000132159 (from geneSymbol) uc335bbm.1 uc335bbm.1 
ENSMUST00000310468.1 ENSMUSG00000132160 ENSMUST00000310468.1 ENSMUSG00000132160 (from geneSymbol) uc335bbq.1 uc335bbq.1 
ENSMUST00000310469.1 ENSMUSG00000132161 ENSMUST00000310469.1 ENSMUSG00000132161 (from geneSymbol) uc335bbr.1 uc335bbr.1 
ENSMUST00000310470.1 ENSMUSG00000132162 ENSMUST00000310470.1 ENSMUSG00000132162 (from geneSymbol) uc335bbs.1 uc335bbs.1 
ENSMUST00000310475.1 ENSMUSG00000132163 ENSMUST00000310475.1 ENSMUSG00000132163 (from geneSymbol) uc335bbx.1 uc335bbx.1 
ENSMUST00000310487.1 ENSMUSG00000132164 ENSMUST00000310487.1 ENSMUSG00000132164 (from geneSymbol) uc335bcj.1 uc335bcj.1 
ENSMUST00000310488.1 ENSMUSG00000132165 ENSMUST00000310488.1 ENSMUSG00000132165 (from geneSymbol) uc335bck.1 uc335bck.1 
ENSMUST00000310491.1 ENSMUSG00000132166 ENSMUST00000310491.1 ENSMUSG00000132166 (from geneSymbol) uc335bcn.1 uc335bcn.1 
ENSMUST00000310493.1 ENSMUSG00000132167 ENSMUST00000310493.1 ENSMUSG00000132167 (from geneSymbol) uc335bcp.1 uc335bcp.1 
ENSMUST00000310496.1 ENSMUSG00000132168 ENSMUST00000310496.1 ENSMUSG00000132168 (from geneSymbol) uc335bcs.1 uc335bcs.1 
ENSMUST00000310497.1 1700109K24Rik ENSMUST00000310497.1 1700109K24Rik (from geneSymbol) AK016913 uc335bct.1 uc335bct.1 
ENSMUST00000310499.1 ENSMUSG00000132169 ENSMUST00000310499.1 ENSMUSG00000132169 (from geneSymbol) uc335bcv.1 uc335bcv.1 
ENSMUST00000310500.1 Gm40649 ENSMUST00000310500.1 Gm40649 (from geneSymbol) AK076832 uc335bcw.1 uc335bcw.1 
ENSMUST00000310506.1 ENSMUSG00000132170 ENSMUST00000310506.1 ENSMUSG00000132170 (from geneSymbol) uc335bdc.1 uc335bdc.1 
ENSMUST00000310507.1 ENSMUSG00000132171 ENSMUST00000310507.1 ENSMUSG00000132171 (from geneSymbol) uc335bdd.1 uc335bdd.1 
ENSMUST00000310508.1 Gm38161 ENSMUST00000310508.1 Gm38161 (from geneSymbol) uc335bde.1 uc335bde.1 
ENSMUST00000310509.1 ENSMUSG00000132172 ENSMUST00000310509.1 ENSMUSG00000132172 (from geneSymbol) uc335bdf.1 uc335bdf.1 
ENSMUST00000310513.1 ENSMUSG00000132173 ENSMUST00000310513.1 ENSMUSG00000132173 (from geneSymbol) uc335bdj.1 uc335bdj.1 
ENSMUST00000310517.1 ENSMUSG00000132174 ENSMUST00000310517.1 ENSMUSG00000132174 (from geneSymbol) uc335bdn.1 uc335bdn.1 
ENSMUST00000310518.1 Runx2os1 ENSMUST00000310518.1 Runx2os1 (from geneSymbol) AK159059 uc335bdo.1 uc335bdo.1 
ENSMUST00000310519.1 ENSMUSG00000132175 ENSMUST00000310519.1 ENSMUSG00000132175 (from geneSymbol) uc335bdp.1 uc335bdp.1 
ENSMUST00000310520.1 ENSMUSG00000132176 ENSMUST00000310520.1 ENSMUSG00000132176 (from geneSymbol) uc335bdq.1 uc335bdq.1 
ENSMUST00000310521.1 ENSMUSG00000132177 ENSMUST00000310521.1 ENSMUSG00000132177 (from geneSymbol) uc335bdr.1 uc335bdr.1 
ENSMUST00000310522.1 ENSMUSG00000132178 ENSMUST00000310522.1 ENSMUSG00000132178 (from geneSymbol) uc335bds.1 uc335bds.1 
ENSMUST00000310524.1 ENSMUSG00000132179 ENSMUST00000310524.1 ENSMUSG00000132179 (from geneSymbol) uc335bdu.1 uc335bdu.1 
ENSMUST00000310526.1 ENSMUSG00000132180 ENSMUST00000310526.1 ENSMUSG00000132180 (from geneSymbol) uc335bdw.1 uc335bdw.1 
ENSMUST00000310527.1 ENSMUSG00000132181 ENSMUST00000310527.1 ENSMUSG00000132181 (from geneSymbol) uc335bdx.1 uc335bdx.1 
ENSMUST00000310537.1 ENSMUSG00000132182 ENSMUST00000310537.1 ENSMUSG00000132182 (from geneSymbol) uc335beh.1 uc335beh.1 
ENSMUST00000310544.1 ENSMUSG00000132183 ENSMUST00000310544.1 ENSMUSG00000132183 (from geneSymbol) uc335beo.1 uc335beo.1 
ENSMUST00000310554.1 ENSMUSG00000132185 ENSMUST00000310554.1 ENSMUSG00000132185 (from geneSymbol) uc335bex.1 uc335bex.1 
ENSMUST00000310555.1 ENSMUSG00000132186 ENSMUST00000310555.1 ENSMUSG00000132186 (from geneSymbol) uc335bey.1 uc335bey.1 
ENSMUST00000310556.1 Gm36485 ENSMUST00000310556.1 Gm36485 (from geneSymbol) uc335bez.1 uc335bez.1 
ENSMUST00000310568.1 Gm57103 ENSMUST00000310568.1 Gm57103 (from geneSymbol) uc335bfl.1 uc335bfl.1 
ENSMUST00000310591.1 ENSMUSG00000132187 ENSMUST00000310591.1 ENSMUSG00000132187 (from geneSymbol) uc335bgi.1 uc335bgi.1 
ENSMUST00000310595.1 ENSMUSG00000132188 ENSMUST00000310595.1 ENSMUSG00000132188 (from geneSymbol) uc335bgm.1 uc335bgm.1 
ENSMUST00000310596.1 ENSMUSG00000132189 ENSMUST00000310596.1 ENSMUSG00000132189 (from geneSymbol) uc335bgn.1 uc335bgn.1 
ENSMUST00000310597.1 ENSMUSG00000132190 ENSMUST00000310597.1 ENSMUSG00000132190 (from geneSymbol) uc335bgo.1 uc335bgo.1 
ENSMUST00000310599.1 ENSMUSG00000132191 ENSMUST00000310599.1 ENSMUSG00000132191 (from geneSymbol) uc335bgq.1 uc335bgq.1 
ENSMUST00000310600.1 ENSMUSG00000132192 ENSMUST00000310600.1 ENSMUSG00000132192 (from geneSymbol) uc335bgr.1 uc335bgr.1 
ENSMUST00000310612.1 Gm11832 ENSMUST00000310612.1 Gm11832 (from geneSymbol) AK050144 uc335bhc.1 uc335bhc.1 
ENSMUST00000310613.1 ENSMUSG00000132193 ENSMUST00000310613.1 ENSMUSG00000132193 (from geneSymbol) uc335bhd.1 uc335bhd.1 
ENSMUST00000310614.1 ENSMUSG00000132194 ENSMUST00000310614.1 ENSMUSG00000132194 (from geneSymbol) uc335bhe.1 uc335bhe.1 
ENSMUST00000310616.1 1700010B08Rik ENSMUST00000310616.1 1700010B08Rik (from geneSymbol) AK005811 uc335bhg.1 uc335bhg.1 
ENSMUST00000310623.1 ENSMUSG00000132195 ENSMUST00000310623.1 ENSMUSG00000132195 (from geneSymbol) uc335bhn.1 uc335bhn.1 
ENSMUST00000310625.1 ENSMUSG00000132196 ENSMUST00000310625.1 ENSMUSG00000132196 (from geneSymbol) uc335bhp.1 uc335bhp.1 
ENSMUST00000310626.1 ENSMUSG00000132197 ENSMUST00000310626.1 ENSMUSG00000132197 (from geneSymbol) uc335bhq.1 uc335bhq.1 
ENSMUST00000310629.1 ENSMUSG00000132198 ENSMUST00000310629.1 ENSMUSG00000132198 (from geneSymbol) uc335bht.1 uc335bht.1 
ENSMUST00000310631.1 Gm36074 ENSMUST00000310631.1 Gm36074 (from geneSymbol) uc335bhv.1 uc335bhv.1 
ENSMUST00000310639.1 Ppp1ccb ENSMUST00000310639.1 Ppp1ccb (from geneSymbol) AK140241 uc335bid.1 uc335bid.1 
ENSMUST00000310648.1 ENSMUSG00000132199 ENSMUST00000310648.1 ENSMUSG00000132199 (from geneSymbol) uc335bim.1 uc335bim.1 
ENSMUST00000310654.1 ENSMUSG00000132200 ENSMUST00000310654.1 ENSMUSG00000132200 (from geneSymbol) uc335bis.1 uc335bis.1 
ENSMUST00000310655.1 ENSMUSG00000132201 ENSMUST00000310655.1 ENSMUSG00000132201 (from geneSymbol) uc335bit.1 uc335bit.1 
ENSMUST00000310656.1 ENSMUSG00000121780 ENSMUST00000310656.1 ENSMUSG00000121780 (from geneSymbol) uc335biu.1 uc335biu.1 
ENSMUST00000310674.1 Gm36229 ENSMUST00000310674.1 Gm36229 (from geneSymbol) AK144827 uc335bjm.1 uc335bjm.1 
ENSMUST00000310695.1 Gm57372 ENSMUST00000310695.1 Gm57372 (from geneSymbol) LF198740 uc335bkh.1 uc335bkh.1 
ENSMUST00000310699.1 ENSMUSG00000132202 ENSMUST00000310699.1 ENSMUSG00000132202 (from geneSymbol) uc335bkl.1 uc335bkl.1 
ENSMUST00000310700.1 Gm5602 ENSMUST00000310700.1 Gm5602 (from geneSymbol) AK138132 uc335bkm.1 uc335bkm.1 
ENSMUST00000310701.1 ENSMUSG00000132203 ENSMUST00000310701.1 ENSMUSG00000132203 (from geneSymbol) uc335bkn.1 uc335bkn.1 
ENSMUST00000310704.1 ENSMUSG00000132204 ENSMUST00000310704.1 ENSMUSG00000132204 (from geneSymbol) uc335bkq.1 uc335bkq.1 
ENSMUST00000310706.1 ENSMUSG00000132205 ENSMUST00000310706.1 ENSMUSG00000132205 (from geneSymbol) uc335bks.1 uc335bks.1 
ENSMUST00000310707.1 ENSMUSG00000132206 ENSMUST00000310707.1 ENSMUSG00000132206 (from geneSymbol) uc335bkt.1 uc335bkt.1 
ENSMUST00000310708.1 ENSMUSG00000132207 ENSMUST00000310708.1 ENSMUSG00000132207 (from geneSymbol) uc335bku.1 uc335bku.1 
ENSMUST00000310723.1 Gm39397 ENSMUST00000310723.1 Gm39397 (from geneSymbol) uc335blj.1 uc335blj.1 
ENSMUST00000310735.1 ENSMUSG00000132208 ENSMUST00000310735.1 ENSMUSG00000132208 (from geneSymbol) uc335blu.1 uc335blu.1 
ENSMUST00000310740.1 ENSMUSG00000132209 ENSMUST00000310740.1 ENSMUSG00000132209 (from geneSymbol) uc335blz.1 uc335blz.1 
ENSMUST00000310753.1 Gm11234 ENSMUST00000310753.1 Gm11234 (from geneSymbol) AK076792 uc335bmm.1 uc335bmm.1 
ENSMUST00000310754.1 ENSMUSG00000132210 ENSMUST00000310754.1 ENSMUSG00000132210 (from geneSymbol) uc335bmn.1 uc335bmn.1 
ENSMUST00000310756.1 ENSMUSG00000132211 ENSMUST00000310756.1 ENSMUSG00000132211 (from geneSymbol) uc335bmp.1 uc335bmp.1 
ENSMUST00000310757.1 ENSMUSG00000132212 ENSMUST00000310757.1 ENSMUSG00000132212 (from geneSymbol) uc335bmq.1 uc335bmq.1 
ENSMUST00000310758.1 ENSMUSG00000132213 ENSMUST00000310758.1 ENSMUSG00000132213 (from geneSymbol) uc335bmr.1 uc335bmr.1 
ENSMUST00000310761.1 ENSMUSG00000132214 ENSMUST00000310761.1 ENSMUSG00000132214 (from geneSymbol) uc335bmu.1 uc335bmu.1 
ENSMUST00000310762.1 ENSMUSG00000132215 ENSMUST00000310762.1 ENSMUSG00000132215 (from geneSymbol) uc335bmv.1 uc335bmv.1 
ENSMUST00000310764.1 ENSMUSG00000132216 ENSMUST00000310764.1 ENSMUSG00000132216 (from geneSymbol) uc335bmx.1 uc335bmx.1 
ENSMUST00000310767.1 Gm36330 ENSMUST00000310767.1 Gm36330 (from geneSymbol) uc335bna.1 uc335bna.1 
ENSMUST00000310768.1 ENSMUSG00000132217 ENSMUST00000310768.1 ENSMUSG00000132217 (from geneSymbol) uc335bnb.1 uc335bnb.1 
ENSMUST00000310772.1 ENSMUSG00000132218 ENSMUST00000310772.1 ENSMUSG00000132218 (from geneSymbol) uc335bnf.1 uc335bnf.1 
ENSMUST00000310801.1 ENSMUSG00000132219 ENSMUST00000310801.1 ENSMUSG00000132219 (from geneSymbol) uc335boi.1 uc335boi.1 
ENSMUST00000310802.1 ENSMUSG00000132220 ENSMUST00000310802.1 ENSMUSG00000132220 (from geneSymbol) uc335boj.1 uc335boj.1 
ENSMUST00000310808.1 ENSMUSG00000132221 ENSMUST00000310808.1 ENSMUSG00000132221 (from geneSymbol) uc335bop.1 uc335bop.1 
ENSMUST00000310810.1 ENSMUSG00000132222 ENSMUST00000310810.1 ENSMUSG00000132222 (from geneSymbol) uc335bor.1 uc335bor.1 
ENSMUST00000310811.1 ENSMUSG00000132223 ENSMUST00000310811.1 ENSMUSG00000132223 (from geneSymbol) uc335bos.1 uc335bos.1 
ENSMUST00000310815.1 4930525C09Rik ENSMUST00000310815.1 4930525C09Rik (from geneSymbol) AK019697 uc335bow.1 uc335bow.1 
ENSMUST00000310839.1 ENSMUSG00000132224 ENSMUST00000310839.1 ENSMUSG00000132224 (from geneSymbol) uc335bpu.1 uc335bpu.1 
ENSMUST00000310853.1 4933404G15Rik ENSMUST00000310853.1 4933404G15Rik (from geneSymbol) AK016649 uc335bqi.1 uc335bqi.1 
ENSMUST00000310862.1 ENSMUSG00000132225 ENSMUST00000310862.1 ENSMUSG00000132225 (from geneSymbol) uc335bqr.1 uc335bqr.1 
ENSMUST00000310863.1 ENSMUSG00000132226 ENSMUST00000310863.1 ENSMUSG00000132226 (from geneSymbol) uc335bqs.1 uc335bqs.1 
ENSMUST00000310864.1 Gm36355 ENSMUST00000310864.1 Gm36355 (from geneSymbol) uc335bqt.1 uc335bqt.1 
ENSMUST00000310883.1 ENSMUSG00000132227 ENSMUST00000310883.1 ENSMUSG00000132227 (from geneSymbol) uc335brm.1 uc335brm.1 
ENSMUST00000310884.1 Gas5 ENSMUST00000310884.1 Gas5 (from geneSymbol) BC004622 uc335brn.1 uc335brn.1 
ENSMUST00000310989.1 ENSMUSG00000132228 ENSMUST00000310989.1 ENSMUSG00000132228 (from geneSymbol) uc335buq.1 uc335buq.1 
ENSMUST00000310991.1 ENSMUSG00000132229 ENSMUST00000310991.1 ENSMUSG00000132229 (from geneSymbol) uc335bus.1 uc335bus.1 
ENSMUST00000311011.1 Gm13598 ENSMUST00000311011.1 Gm13598 (from geneSymbol) AK076676 uc335bvm.1 uc335bvm.1 
ENSMUST00000311019.1 ENSMUSG00000132230 ENSMUST00000311019.1 ENSMUSG00000132230 (from geneSymbol) uc335bvu.1 uc335bvu.1 
ENSMUST00000311039.1 ENSMUSG00000132231 ENSMUST00000311039.1 ENSMUSG00000132231 (from geneSymbol) uc335bwo.1 uc335bwo.1 
ENSMUST00000311040.1 ENSMUSG00000132232 ENSMUST00000311040.1 ENSMUSG00000132232 (from geneSymbol) uc335bwp.1 uc335bwp.1 
ENSMUST00000311045.1 ENSMUSG00000132233 ENSMUST00000311045.1 ENSMUSG00000132233 (from geneSymbol) uc335bwu.1 uc335bwu.1 
ENSMUST00000311046.1 ENSMUSG00000132234 ENSMUST00000311046.1 ENSMUSG00000132234 (from geneSymbol) uc335bwv.1 uc335bwv.1 
ENSMUST00000311050.1 ENSMUSG00000132235 ENSMUST00000311050.1 ENSMUSG00000132235 (from geneSymbol) uc335bwz.1 uc335bwz.1 
ENSMUST00000311051.1 ENSMUSG00000132236 ENSMUST00000311051.1 ENSMUSG00000132236 (from geneSymbol) uc335bxa.1 uc335bxa.1 
ENSMUST00000311057.1 ENSMUSG00000132237 ENSMUST00000311057.1 ENSMUSG00000132237 (from geneSymbol) uc335bxg.1 uc335bxg.1 
ENSMUST00000311060.1 ENSMUSG00000132238 ENSMUST00000311060.1 RIKEN cDNA 0610039H22 gene (from RefSeq NR_131025.1) NR_131025 uc335bxj.1 uc335bxj.1 
ENSMUST00000311104.1 4930564C03Rik ENSMUST00000311104.1 4930564C03Rik (from geneSymbol) uc335byo.1 uc335byo.1 
ENSMUST00000311106.1 A530041M06Rik ENSMUST00000311106.1 A530041M06Rik (from geneSymbol) uc335byq.1 uc335byq.1 
ENSMUST00000311113.1 ENSMUSG00000132241 ENSMUST00000311113.1 ENSMUSG00000132241 (from geneSymbol) uc335byx.1 uc335byx.1 
ENSMUST00000311114.1 ENSMUSG00000132242 ENSMUST00000311114.1 ENSMUSG00000132242 (from geneSymbol) uc335byy.1 uc335byy.1 
ENSMUST00000311115.1 ENSMUSG00000132243 ENSMUST00000311115.1 ENSMUSG00000132243 (from geneSymbol) uc335byz.1 uc335byz.1 
ENSMUST00000311118.1 ENSMUSG00000132244 ENSMUST00000311118.1 ENSMUSG00000132244 (from geneSymbol) uc335bzc.1 uc335bzc.1 
ENSMUST00000311119.1 ENSMUSG00000132245 ENSMUST00000311119.1 ENSMUSG00000132245 (from geneSymbol) uc335bzd.1 uc335bzd.1 
ENSMUST00000311120.1 ENSMUSG00000132246 ENSMUST00000311120.1 ENSMUSG00000132246 (from geneSymbol) uc335bze.1 uc335bze.1 
ENSMUST00000311121.1 ENSMUSG00000132247 ENSMUST00000311121.1 ENSMUSG00000132247 (from geneSymbol) uc335bzf.1 uc335bzf.1 
ENSMUST00000311123.1 ENSMUSG00000132248 ENSMUST00000311123.1 ENSMUSG00000132248 (from geneSymbol) uc335bzh.1 uc335bzh.1 
ENSMUST00000311125.1 ENSMUSG00000132249 ENSMUST00000311125.1 ENSMUSG00000132249 (from geneSymbol) uc335bzj.1 uc335bzj.1 
ENSMUST00000311132.1 9330198I05Rik ENSMUST00000311132.1 9330198I05Rik (from geneSymbol) AK020394 uc335bzq.1 uc335bzq.1 
ENSMUST00000311145.1 ENSMUSG00000132250 ENSMUST00000311145.1 ENSMUSG00000132250 (from geneSymbol) uc335cad.1 uc335cad.1 
ENSMUST00000311148.1 ENSMUSG00000132251 ENSMUST00000311148.1 ENSMUSG00000132251 (from geneSymbol) uc335cag.1 uc335cag.1 
ENSMUST00000311150.1 ENSMUSG00000132252 ENSMUST00000311150.1 ENSMUSG00000132252 (from geneSymbol) uc335cai.1 uc335cai.1 
ENSMUST00000311151.1 ENSMUSG00000132253 ENSMUST00000311151.1 ENSMUSG00000132253 (from geneSymbol) uc335caj.1 uc335caj.1 
ENSMUST00000311152.1 ENSMUSG00000132254 ENSMUST00000311152.1 ENSMUSG00000132254 (from geneSymbol) uc335cak.1 uc335cak.1 
ENSMUST00000311171.1 ENSMUSG00000132255 ENSMUST00000311171.1 ENSMUSG00000132255 (from geneSymbol) uc335cbd.1 uc335cbd.1 
ENSMUST00000311200.1 ENSMUSG00000132256 ENSMUST00000311200.1 ENSMUSG00000132256 (from geneSymbol) uc335ccg.1 uc335ccg.1 
ENSMUST00000311201.1 ENSMUSG00000132257 ENSMUST00000311201.1 ENSMUSG00000132257 (from geneSymbol) AB349574 uc335cch.1 uc335cch.1 
ENSMUST00000311203.1 ENSMUSG00000132259 ENSMUST00000311203.1 ENSMUSG00000132259 (from geneSymbol) uc335cci.1 uc335cci.1 
ENSMUST00000311206.1 4930473O22Rik ENSMUST00000311206.1 4930473O22Rik (from geneSymbol) uc335ccl.1 uc335ccl.1 
ENSMUST00000311225.1 ENSMUSG00000132260 ENSMUST00000311225.1 ENSMUSG00000132260 (from geneSymbol) uc335cde.1 uc335cde.1 
ENSMUST00000311226.1 Gm34152 ENSMUST00000311226.1 Gm34152 (from geneSymbol) uc335cdf.1 uc335cdf.1 
ENSMUST00000311232.1 ENSMUSG00000132261 ENSMUST00000311232.1 ENSMUSG00000132261 (from geneSymbol) uc335cdl.1 uc335cdl.1 
ENSMUST00000311233.1 ENSMUSG00000132262 ENSMUST00000311233.1 ENSMUSG00000132262 (from geneSymbol) uc335cdm.1 uc335cdm.1 
ENSMUST00000311237.1 ENSMUSG00000132263 ENSMUST00000311237.1 ENSMUSG00000132263 (from geneSymbol) uc335cdq.1 uc335cdq.1 
ENSMUST00000311239.1 Gm16287 ENSMUST00000311239.1 Gm16287 (from geneSymbol) AK141099 uc335cds.1 uc335cds.1 
ENSMUST00000311250.1 ENSMUSG00000144216 ENSMUST00000311250.1 ENSMUSG00000144216 (from geneSymbol) uc335ced.1 uc335ced.1 
ENSMUST00000311259.1 ENSMUSG00000132264 ENSMUST00000311259.1 ENSMUSG00000132264 (from geneSymbol) uc335cem.1 uc335cem.1 
ENSMUST00000311261.1 Gm30928 ENSMUST00000311261.1 Gm30928 (from geneSymbol) uc335ceo.1 uc335ceo.1 
ENSMUST00000311278.1 ENSMUSG00000132265 ENSMUST00000311278.1 ENSMUSG00000132265 (from geneSymbol) uc335cff.1 uc335cff.1 
ENSMUST00000311300.1 ENSMUSG00000132266 ENSMUST00000311300.1 ENSMUSG00000132266 (from geneSymbol) uc335cga.1 uc335cga.1 
ENSMUST00000311311.1 ENSMUSG00000132268 ENSMUST00000311311.1 ENSMUSG00000132268 (from geneSymbol) uc335cgk.1 uc335cgk.1 
ENSMUST00000311315.1 ENSMUSG00000132269 ENSMUST00000311315.1 ENSMUSG00000132269 (from geneSymbol) uc335cgo.1 uc335cgo.1 
ENSMUST00000311319.1 ENSMUSG00000132270 ENSMUST00000311319.1 ENSMUSG00000132270 (from geneSymbol) uc335cgs.1 uc335cgs.1 
ENSMUST00000311345.1 ENSMUSG00000132271 ENSMUST00000311345.1 ENSMUSG00000132271 (from geneSymbol) uc335chs.1 uc335chs.1 
ENSMUST00000311346.1 ENSMUSG00000132272 ENSMUST00000311346.1 ENSMUSG00000132272 (from geneSymbol) uc335cht.1 uc335cht.1 
ENSMUST00000311349.1 ENSMUSG00000132273 ENSMUST00000311349.1 ENSMUSG00000132273 (from geneSymbol) uc335chw.1 uc335chw.1 
ENSMUST00000311352.1 Gm33472 ENSMUST00000311352.1 Gm33472 (from geneSymbol) uc335chz.1 uc335chz.1 
ENSMUST00000311359.1 ENSMUSG00000132274 ENSMUST00000311359.1 ENSMUSG00000132274 (from geneSymbol) uc335cig.1 uc335cig.1 
ENSMUST00000311361.1 ENSMUSG00000132275 ENSMUST00000311361.1 ENSMUSG00000132275 (from geneSymbol) uc335cii.1 uc335cii.1 
ENSMUST00000311362.1 ENSMUSG00000132276 ENSMUST00000311362.1 ENSMUSG00000132276 (from geneSymbol) uc335cij.1 uc335cij.1 
ENSMUST00000311364.1 ENSMUSG00000132277 ENSMUST00000311364.1 ENSMUSG00000132277 (from geneSymbol) LF197828 uc335cik.1 uc335cik.1 
ENSMUST00000311365.1 4930481A15Rik ENSMUST00000311365.1 4930481A15Rik (from geneSymbol) BC085508 uc335cil.1 uc335cil.1 
ENSMUST00000311399.1 1700112J16Rik ENSMUST00000311399.1 1700112J16Rik (from geneSymbol) AK038598 uc335cjt.1 uc335cjt.1 
ENSMUST00000311416.1 ENSMUSG00000132279 ENSMUST00000311416.1 ENSMUSG00000132279 (from geneSymbol) uc335ckj.1 uc335ckj.1 
ENSMUST00000311417.1 ENSMUSG00000132280 ENSMUST00000311417.1 ENSMUSG00000132280 (from geneSymbol) uc335ckk.1 uc335ckk.1 
ENSMUST00000311418.1 ENSMUSG00000132281 ENSMUST00000311418.1 ENSMUSG00000132281 (from geneSymbol) DQ708576 uc335ckl.1 uc335ckl.1 
ENSMUST00000311419.1 ENSMUSG00000132282 ENSMUST00000311419.1 ENSMUSG00000132282 (from geneSymbol) uc335ckm.1 uc335ckm.1 
ENSMUST00000311423.1 Gm47425 ENSMUST00000311423.1 Gm47425 (from geneSymbol) uc335ckq.1 uc335ckq.1 
ENSMUST00000311438.1 ENSMUSG00000132283 ENSMUST00000311438.1 ENSMUSG00000132283 (from geneSymbol) uc335clf.1 uc335clf.1 
ENSMUST00000311441.1 ENSMUSG00000132284 ENSMUST00000311441.1 ENSMUSG00000132284 (from geneSymbol) uc335cli.1 uc335cli.1 
ENSMUST00000311442.1 ENSMUSG00000132285 ENSMUST00000311442.1 ENSMUSG00000132285 (from geneSymbol) uc335clj.1 uc335clj.1 
ENSMUST00000311445.1 ENSMUSG00000132286 ENSMUST00000311445.1 ENSMUSG00000132286 (from geneSymbol) uc335clm.1 uc335clm.1 
ENSMUST00000311447.1 ENSMUSG00000132287 ENSMUST00000311447.1 ENSMUSG00000132287 (from geneSymbol) uc335clo.1 uc335clo.1 
ENSMUST00000311449.1 ENSMUSG00000132288 ENSMUST00000311449.1 ENSMUSG00000132288 (from geneSymbol) uc335clq.1 uc335clq.1 
ENSMUST00000311450.1 ENSMUSG00000132289 ENSMUST00000311450.1 ENSMUSG00000132289 (from geneSymbol) uc335clr.1 uc335clr.1 
ENSMUST00000311451.1 ENSMUSG00000132290 ENSMUST00000311451.1 ENSMUSG00000132290 (from geneSymbol) uc335cls.1 uc335cls.1 
ENSMUST00000311453.1 ENSMUSG00000132291 ENSMUST00000311453.1 ENSMUSG00000132291 (from geneSymbol) uc335clu.1 uc335clu.1 
ENSMUST00000311454.1 ENSMUSG00000132292 ENSMUST00000311454.1 ENSMUSG00000132292 (from geneSymbol) uc335clv.1 uc335clv.1 
ENSMUST00000311455.1 ENSMUSG00000132293 ENSMUST00000311455.1 ENSMUSG00000132293 (from geneSymbol) uc335clw.1 uc335clw.1 
ENSMUST00000311458.1 ENSMUSG00000132294 ENSMUST00000311458.1 ENSMUSG00000132294 (from geneSymbol) AK132135 uc335clz.1 uc335clz.1 
ENSMUST00000311459.1 ENSMUSG00000132295 ENSMUST00000311459.1 ENSMUSG00000132295 (from geneSymbol) uc335cma.1 uc335cma.1 
ENSMUST00000311462.1 ENSMUSG00000132296 ENSMUST00000311462.1 ENSMUSG00000132296 (from geneSymbol) uc335cmd.1 uc335cmd.1 
ENSMUST00000311466.1 ENSMUSG00000132297 ENSMUST00000311466.1 ENSMUSG00000132297 (from geneSymbol) uc335cmh.1 uc335cmh.1 
ENSMUST00000311469.1 Gm30735 ENSMUST00000311469.1 predicted gene, 30735, transcript variant 2 (from RefSeq NR_189172.1) NR_189172 uc335cmk.1 uc335cmk.1 
ENSMUST00000311481.1 Gm1604a ENSMUST00000311481.1 predicted gene 1604A, transcript variant 4 (from RefSeq NR_168937.1) NR_168937 uc335cmw.1 uc335cmw.1 
ENSMUST00000311490.1 ENSMUSG00000132298 ENSMUST00000311490.1 ENSMUSG00000132298 (from geneSymbol) uc335cnc.1 uc335cnc.1 
ENSMUST00000311499.1 ENSMUSG00000132299 ENSMUST00000311499.1 ENSMUSG00000132299 (from geneSymbol) uc335cnl.1 uc335cnl.1 
ENSMUST00000311501.1 ENSMUSG00000132300 ENSMUST00000311501.1 ENSMUSG00000132300 (from geneSymbol) uc335cnn.1 uc335cnn.1 
ENSMUST00000311502.1 ENSMUSG00000132301 ENSMUST00000311502.1 ENSMUSG00000132301 (from geneSymbol) uc335cno.1 uc335cno.1 
ENSMUST00000311504.1 ENSMUSG00000132302 ENSMUST00000311504.1 ENSMUSG00000132302 (from geneSymbol) uc335cnq.1 uc335cnq.1 
ENSMUST00000311505.1 ENSMUSG00000132303 ENSMUST00000311505.1 ENSMUSG00000132303 (from geneSymbol) uc335cnr.1 uc335cnr.1 
ENSMUST00000311506.1 ENSMUSG00000132304 ENSMUST00000311506.1 ENSMUSG00000132304 (from geneSymbol) LF201168 uc335cns.1 uc335cns.1 
ENSMUST00000311507.1 ENSMUSG00000132305 ENSMUST00000311507.1 ENSMUSG00000132305 (from geneSymbol) uc335cnt.1 uc335cnt.1 
ENSMUST00000311508.1 ENSMUSG00000132306 ENSMUST00000311508.1 ENSMUSG00000132306 (from geneSymbol) uc335cnu.1 uc335cnu.1 
ENSMUST00000311514.1 ENSMUSG00000132307 ENSMUST00000311514.1 ENSMUSG00000132307 (from geneSymbol) uc335coa.1 uc335coa.1 
ENSMUST00000311516.1 ENSMUSG00000132308 ENSMUST00000311516.1 ENSMUSG00000132308 (from geneSymbol) uc335coc.1 uc335coc.1 
ENSMUST00000311525.1 ENSMUSG00000132309 ENSMUST00000311525.1 ENSMUSG00000132309 (from geneSymbol) uc335col.1 uc335col.1 
ENSMUST00000311532.1 ENSMUSG00000132310 ENSMUST00000311532.1 ENSMUSG00000132310 (from geneSymbol) uc335cor.1 uc335cor.1 
ENSMUST00000311536.1 ENSMUSG00000132311 ENSMUST00000311536.1 ENSMUSG00000132311 (from geneSymbol) uc335cov.1 uc335cov.1 
ENSMUST00000311537.1 ENSMUSG00000132312 ENSMUST00000311537.1 ENSMUSG00000132312 (from geneSymbol) uc335cow.1 uc335cow.1 
ENSMUST00000311540.1 ENSMUSG00000132313 ENSMUST00000311540.1 ENSMUSG00000132313 (from geneSymbol) uc335coz.1 uc335coz.1 
ENSMUST00000311544.1 ENSMUSG00000132314 ENSMUST00000311544.1 ENSMUSG00000132314 (from geneSymbol) uc335cpd.1 uc335cpd.1 
ENSMUST00000311545.1 ENSMUSG00000132315 ENSMUST00000311545.1 ENSMUSG00000132315 (from geneSymbol) uc335cpe.1 uc335cpe.1 
ENSMUST00000311546.1 ENSMUSG00000132316 ENSMUST00000311546.1 ENSMUSG00000132316 (from geneSymbol) uc335cpf.1 uc335cpf.1 
ENSMUST00000311548.1 ENSMUSG00000132317 ENSMUST00000311548.1 ENSMUSG00000132317 (from geneSymbol) uc335cph.1 uc335cph.1 
ENSMUST00000311568.1 Gm41162 ENSMUST00000311568.1 Gm41162 (from geneSymbol) uc335cqb.1 uc335cqb.1 
ENSMUST00000311569.1 ENSMUSG00000132318 ENSMUST00000311569.1 ENSMUSG00000132318 (from geneSymbol) uc335cqc.1 uc335cqc.1 
ENSMUST00000311578.1 Gm47790 ENSMUST00000311578.1 Gm47790 (from geneSymbol) uc335cql.1 uc335cql.1 
ENSMUST00000311589.1 Gm52182 ENSMUST00000311589.1 Gm52182 (from geneSymbol) uc335cqw.1 uc335cqw.1 
ENSMUST00000311593.1 ENSMUSG00000132319 ENSMUST00000311593.1 ENSMUSG00000132319 (from geneSymbol) uc335cra.1 uc335cra.1 
ENSMUST00000311595.1 ENSMUSG00000132320 ENSMUST00000311595.1 ENSMUSG00000132320 (from geneSymbol) uc335crc.1 uc335crc.1 
ENSMUST00000311596.1 ENSMUSG00000132321 ENSMUST00000311596.1 ENSMUSG00000132321 (from geneSymbol) uc335crd.1 uc335crd.1 
ENSMUST00000311599.1 ENSMUSG00000132322 ENSMUST00000311599.1 ENSMUSG00000132322 (from geneSymbol) uc335crg.1 uc335crg.1 
ENSMUST00000311601.1 ENSMUSG00000132323 ENSMUST00000311601.1 ENSMUSG00000132323 (from geneSymbol) uc335cri.1 uc335cri.1 
ENSMUST00000311602.1 ENSMUSG00000132324 ENSMUST00000311602.1 ENSMUSG00000132324 (from geneSymbol) uc335crj.1 uc335crj.1 
ENSMUST00000311603.1 ENSMUSG00000132325 ENSMUST00000311603.1 ENSMUSG00000132325 (from geneSymbol) uc335crk.1 uc335crk.1 
ENSMUST00000311607.1 ENSMUSG00000132326 ENSMUST00000311607.1 ENSMUSG00000132326 (from geneSymbol) uc335cro.1 uc335cro.1 
ENSMUST00000311608.1 ENSMUSG00000132327 ENSMUST00000311608.1 ENSMUSG00000132327 (from geneSymbol) uc335crp.1 uc335crp.1 
ENSMUST00000311609.1 ENSMUSG00000132328 ENSMUST00000311609.1 ENSMUSG00000132328 (from geneSymbol) uc335crq.1 uc335crq.1 
ENSMUST00000311610.1 ENSMUSG00000132329 ENSMUST00000311610.1 ENSMUSG00000132329 (from geneSymbol) uc335crr.1 uc335crr.1 
ENSMUST00000311616.1 ENSMUSG00000132330 ENSMUST00000311616.1 ENSMUSG00000132330 (from geneSymbol) uc335crx.1 uc335crx.1 
ENSMUST00000311621.1 ENSMUSG00000132331 ENSMUST00000311621.1 ENSMUSG00000132331 (from geneSymbol) uc335csc.1 uc335csc.1 
ENSMUST00000311623.1 ENSMUSG00000132332 ENSMUST00000311623.1 ENSMUSG00000132332 (from geneSymbol) uc335cse.1 uc335cse.1 
ENSMUST00000311624.1 ENSMUSG00000132333 ENSMUST00000311624.1 ENSMUSG00000132333 (from geneSymbol) AK018927 uc335csf.1 uc335csf.1 
ENSMUST00000311626.1 ENSMUSG00000132334 ENSMUST00000311626.1 ENSMUSG00000132334 (from geneSymbol) uc335csh.1 uc335csh.1 
ENSMUST00000311628.1 ENSMUSG00000132335 ENSMUST00000311628.1 ENSMUSG00000132335 (from geneSymbol) uc335csj.1 uc335csj.1 
ENSMUST00000311630.1 ENSMUSG00000132336 ENSMUST00000311630.1 ENSMUSG00000132336 (from geneSymbol) uc335csl.1 uc335csl.1 
ENSMUST00000311633.1 ENSMUSG00000132337 ENSMUST00000311633.1 ENSMUSG00000132337 (from geneSymbol) uc335cso.1 uc335cso.1 
ENSMUST00000311637.1 Gm31870 ENSMUST00000311637.1 Gm31870 (from geneSymbol) uc335css.1 uc335css.1 
ENSMUST00000311659.1 ENSMUSG00000132338 ENSMUST00000311659.1 ENSMUSG00000132338 (from geneSymbol) uc335cto.1 uc335cto.1 
ENSMUST00000311667.1 ENSMUSG00000132339 ENSMUST00000311667.1 ENSMUSG00000132339 (from geneSymbol) uc335ctw.1 uc335ctw.1 
ENSMUST00000311670.1 ENSMUSG00000132340 ENSMUST00000311670.1 ENSMUSG00000132340 (from geneSymbol) uc335ctz.1 uc335ctz.1 
ENSMUST00000311671.1 ENSMUSG00000132341 ENSMUST00000311671.1 ENSMUSG00000132341 (from geneSymbol) uc335cua.1 uc335cua.1 
ENSMUST00000311672.1 ENSMUSG00000132342 ENSMUST00000311672.1 ENSMUSG00000132342 (from geneSymbol) uc335cub.1 uc335cub.1 
ENSMUST00000311676.1 1700016J18Rik ENSMUST00000311676.1 1700016J18Rik (from geneSymbol) AK006037 uc335cuf.1 uc335cuf.1 
ENSMUST00000311686.1 ENSMUSG00000132343 ENSMUST00000311686.1 ENSMUSG00000132343 (from geneSymbol) uc335cup.1 uc335cup.1 
ENSMUST00000311688.1 ENSMUSG00000132344 ENSMUST00000311688.1 ENSMUSG00000132344 (from geneSymbol) uc335cur.1 uc335cur.1 
ENSMUST00000311696.1 Gm16537 ENSMUST00000311696.1 Gm16537 (from geneSymbol) AK140856 uc335cuz.1 uc335cuz.1 
ENSMUST00000311722.1 ENSMUSG00000132345 ENSMUST00000311722.1 ENSMUSG00000132345 (from geneSymbol) uc335cvz.1 uc335cvz.1 
ENSMUST00000311729.1 ENSMUSG00000132346 ENSMUST00000311729.1 ENSMUSG00000132346 (from geneSymbol) uc335cwg.1 uc335cwg.1 
ENSMUST00000311731.1 ENSMUSG00000132347 ENSMUST00000311731.1 ENSMUSG00000132347 (from geneSymbol) uc335cwi.1 uc335cwi.1 
ENSMUST00000311732.1 ENSMUSG00000132348 ENSMUST00000311732.1 ENSMUSG00000132348 (from geneSymbol) uc335cwj.1 uc335cwj.1 
ENSMUST00000311734.1 ENSMUSG00000132349 ENSMUST00000311734.1 ENSMUSG00000132349 (from geneSymbol) uc335cwl.1 uc335cwl.1 
ENSMUST00000311735.1 Gm20627 ENSMUST00000311735.1 Gm20627 (from geneSymbol) uc335cwm.1 uc335cwm.1 
ENSMUST00000311738.1 ENSMUSG00000132351 ENSMUST00000311738.1 ENSMUSG00000132351 (from geneSymbol) uc335cwo.1 uc335cwo.1 
ENSMUST00000311739.1 1700065O20Rik ENSMUST00000311739.1 1700065O20Rik (from geneSymbol) AK006898 uc335cwp.1 uc335cwp.1 
ENSMUST00000311747.1 ENSMUSG00000132352 ENSMUST00000311747.1 ENSMUSG00000132352 (from geneSymbol) uc335cwx.1 uc335cwx.1 
ENSMUST00000311750.1 ENSMUSG00000132353 ENSMUST00000311750.1 ENSMUSG00000132353 (from geneSymbol) uc335cxa.1 uc335cxa.1 
ENSMUST00000311751.1 ENSMUSG00000132354 ENSMUST00000311751.1 ENSMUSG00000132354 (from geneSymbol) uc335cxb.1 uc335cxb.1 
ENSMUST00000311752.1 ENSMUSG00000132355 ENSMUST00000311752.1 ENSMUSG00000132355 (from geneSymbol) uc335cxc.1 uc335cxc.1 
ENSMUST00000311754.1 ENSMUSG00000132356 ENSMUST00000311754.1 ENSMUSG00000132356 (from geneSymbol) uc335cxe.1 uc335cxe.1 
ENSMUST00000311755.1 ENSMUSG00000132357 ENSMUST00000311755.1 ENSMUSG00000132357 (from geneSymbol) uc335cxf.1 uc335cxf.1 
ENSMUST00000311757.1 ENSMUSG00000132358 ENSMUST00000311757.1 ENSMUSG00000132358 (from geneSymbol) uc335cxh.1 uc335cxh.1 
ENSMUST00000311758.1 ENSMUSG00000132359 ENSMUST00000311758.1 ENSMUSG00000132359 (from geneSymbol) uc335cxi.1 uc335cxi.1 
ENSMUST00000311759.1 ENSMUSG00000132360 ENSMUST00000311759.1 ENSMUSG00000132360 (from geneSymbol) uc335cxj.1 uc335cxj.1 
ENSMUST00000311761.1 ENSMUSG00000132361 ENSMUST00000311761.1 ENSMUSG00000132361 (from geneSymbol) uc335cxl.1 uc335cxl.1 
ENSMUST00000311762.1 ENSMUSG00000132362 ENSMUST00000311762.1 ENSMUSG00000132362 (from geneSymbol) uc335cxm.1 uc335cxm.1 
ENSMUST00000311766.1 ENSMUSG00000132363 ENSMUST00000311766.1 ENSMUSG00000132363 (from geneSymbol) uc335cxq.1 uc335cxq.1 
ENSMUST00000311767.1 ENSMUSG00000132364 ENSMUST00000311767.1 ENSMUSG00000132364 (from geneSymbol) LF203433 uc335cxr.1 uc335cxr.1 
ENSMUST00000311768.1 ENSMUSG00000132365 ENSMUST00000311768.1 ENSMUSG00000132365 (from geneSymbol) uc335cxs.1 uc335cxs.1 
ENSMUST00000311774.1 Gm57412 ENSMUST00000311774.1 Gm57412 (from geneSymbol) uc335cxy.1 uc335cxy.1 
ENSMUST00000311776.1 Gm50323 ENSMUST00000311776.1 Gm50323 (from geneSymbol) AK141626 uc335cya.1 uc335cya.1 
ENSMUST00000311786.1 ENSMUSG00000132367 ENSMUST00000311786.1 ENSMUSG00000132367 (from geneSymbol) uc335cyk.1 uc335cyk.1 
ENSMUST00000311787.1 ENSMUSG00000132368 ENSMUST00000311787.1 ENSMUSG00000132368 (from geneSymbol) uc335cyl.1 uc335cyl.1 
ENSMUST00000311789.1 ENSMUSG00000132369 ENSMUST00000311789.1 ENSMUSG00000132369 (from geneSymbol) uc335cyn.1 uc335cyn.1 
ENSMUST00000311795.1 ENSMUSG00000132370 ENSMUST00000311795.1 ENSMUSG00000132370 (from geneSymbol) BC022618 uc335cyt.1 uc335cyt.1 
ENSMUST00000311797.1 ENSMUSG00000132371 ENSMUST00000311797.1 ENSMUSG00000132371 (from geneSymbol) uc335cyv.1 uc335cyv.1 
ENSMUST00000311800.1 Gm14862 ENSMUST00000311800.1 Gm14862 (from geneSymbol) AK156771 uc335cyy.1 uc335cyy.1 
ENSMUST00000311803.1 ENSMUSG00000132372 ENSMUST00000311803.1 ENSMUSG00000132372 (from geneSymbol) uc335czb.1 uc335czb.1 
ENSMUST00000311804.1 ENSMUSG00000132373 ENSMUST00000311804.1 ENSMUSG00000132373 (from geneSymbol) uc335czc.1 uc335czc.1 
ENSMUST00000311825.1 ENSMUSG00000132374 ENSMUST00000311825.1 ENSMUSG00000132374 (from geneSymbol) uc335czx.1 uc335czx.1 
ENSMUST00000311826.1 ENSMUSG00000132375 ENSMUST00000311826.1 ENSMUSG00000132375 (from geneSymbol) uc335czy.1 uc335czy.1 
ENSMUST00000311828.1 ENSMUSG00000132376 ENSMUST00000311828.1 ENSMUSG00000132376 (from geneSymbol) uc335daa.1 uc335daa.1 
ENSMUST00000311829.1 ENSMUSG00000132377 ENSMUST00000311829.1 ENSMUSG00000132377 (from geneSymbol) uc335dab.1 uc335dab.1 
ENSMUST00000311832.1 ENSMUSG00000132378 ENSMUST00000311832.1 ENSMUSG00000132378 (from geneSymbol) uc335dae.1 uc335dae.1 
ENSMUST00000311833.1 ENSMUSG00000132379 ENSMUST00000311833.1 ENSMUSG00000132379 (from geneSymbol) uc335daf.1 uc335daf.1 
ENSMUST00000311843.1 Gm56542 ENSMUST00000311843.1 Gm56542 (from geneSymbol) BC031891 uc335dap.1 uc335dap.1 
ENSMUST00000311847.1 ENSMUSG00000132380 ENSMUST00000311847.1 ENSMUSG00000132380 (from geneSymbol) uc335dat.1 uc335dat.1 
ENSMUST00000311852.1 ENSMUSG00000132381 ENSMUST00000311852.1 ENSMUSG00000132381 (from geneSymbol) uc335day.1 uc335day.1 
ENSMUST00000311854.1 ENSMUSG00000132382 ENSMUST00000311854.1 ENSMUSG00000132382 (from geneSymbol) uc335dba.1 uc335dba.1 
ENSMUST00000311860.1 ENSMUSG00000132383 ENSMUST00000311860.1 ENSMUSG00000132383 (from geneSymbol) uc335dbg.1 uc335dbg.1 
ENSMUST00000311862.1 ENSMUSG00000132384 ENSMUST00000311862.1 ENSMUSG00000132384 (from geneSymbol) uc335dbi.1 uc335dbi.1 
ENSMUST00000311863.1 ENSMUSG00000132385 ENSMUST00000311863.1 ENSMUSG00000132385 (from geneSymbol) uc335dbj.1 uc335dbj.1 
ENSMUST00000311864.1 ENSMUSG00000132386 ENSMUST00000311864.1 ENSMUSG00000132386 (from geneSymbol) uc335dbk.1 uc335dbk.1 
ENSMUST00000311868.1 ENSMUSG00000132387 ENSMUST00000311868.1 ENSMUSG00000132387 (from geneSymbol) uc335dbo.1 uc335dbo.1 
ENSMUST00000311870.1 ENSMUSG00000132388 ENSMUST00000311870.1 ENSMUSG00000132388 (from geneSymbol) uc335dbq.1 uc335dbq.1 
ENSMUST00000311876.1 Gm13596 ENSMUST00000311876.1 Gm13596 (from geneSymbol) uc335dbw.1 uc335dbw.1 
ENSMUST00000311888.1 ENSMUSG00000132389 ENSMUST00000311888.1 ENSMUSG00000132389 (from geneSymbol) FV526417 uc335dch.1 uc335dch.1 
ENSMUST00000311889.1 ENSMUSG00000132390 ENSMUST00000311889.1 ENSMUSG00000132390 (from geneSymbol) uc335dci.1 uc335dci.1 
ENSMUST00000311890.1 ENSMUSG00000132391 ENSMUST00000311890.1 ENSMUSG00000132391 (from geneSymbol) uc335dcj.1 uc335dcj.1 
ENSMUST00000311893.1 4930465M20Rik ENSMUST00000311893.1 4930465M20Rik (from geneSymbol) AK015269 uc335dcm.1 uc335dcm.1 
ENSMUST00000311924.1 ENSMUSG00000132392 ENSMUST00000311924.1 ENSMUSG00000132392 (from geneSymbol) uc335ddr.1 uc335ddr.1 
ENSMUST00000311927.1 ENSMUSG00000132393 ENSMUST00000311927.1 ENSMUSG00000132393 (from geneSymbol) uc335ddu.1 uc335ddu.1 
ENSMUST00000311928.1 ENSMUSG00000132394 ENSMUST00000311928.1 ENSMUSG00000132394 (from geneSymbol) uc335ddv.1 uc335ddv.1 
ENSMUST00000311929.1 ENSMUSG00000132395 ENSMUST00000311929.1 ENSMUSG00000132395 (from geneSymbol) uc335ddw.1 uc335ddw.1 
ENSMUST00000311930.1 Gm16508 ENSMUST00000311930.1 Gm16508 (from geneSymbol) AY512943 uc335ddx.1 uc335ddx.1 
ENSMUST00000311933.1 ENSMUSG00000132396 ENSMUST00000311933.1 ENSMUSG00000132396 (from geneSymbol) uc335dea.1 uc335dea.1 
ENSMUST00000311934.1 ENSMUSG00000132397 ENSMUST00000311934.1 ENSMUSG00000132397 (from geneSymbol) uc335deb.1 uc335deb.1 
ENSMUST00000311936.1 ENSMUSG00000132398 ENSMUST00000311936.1 ENSMUSG00000132398 (from geneSymbol) uc335ded.1 uc335ded.1 
ENSMUST00000311939.1 ENSMUSG00000132399 ENSMUST00000311939.1 ENSMUSG00000132399 (from geneSymbol) uc335deg.1 uc335deg.1 
ENSMUST00000311943.1 ENSMUSG00000132400 ENSMUST00000311943.1 ENSMUSG00000132400 (from geneSymbol) uc335dek.1 uc335dek.1 
ENSMUST00000311947.1 ENSMUSG00000132401 ENSMUST00000311947.1 ENSMUSG00000132401 (from geneSymbol) uc335deo.1 uc335deo.1 
ENSMUST00000311949.1 ENSMUSG00000132402 ENSMUST00000311949.1 ENSMUSG00000132402 (from geneSymbol) uc335deq.1 uc335deq.1 
ENSMUST00000311950.1 ENSMUSG00000132403 ENSMUST00000311950.1 ENSMUSG00000132403 (from geneSymbol) uc335der.1 uc335der.1 
ENSMUST00000311952.1 Gm16158 ENSMUST00000311952.1 Gm16158 (from geneSymbol) uc335det.1 uc335det.1 
ENSMUST00000311969.1 ENSMUSG00000132404 ENSMUST00000311969.1 ENSMUSG00000132404 (from geneSymbol) uc335dfk.1 uc335dfk.1 
ENSMUST00000311973.1 ENSMUSG00000132405 ENSMUST00000311973.1 ENSMUSG00000132405 (from geneSymbol) uc335dfo.1 uc335dfo.1 
ENSMUST00000311974.1 ENSMUSG00000132406 ENSMUST00000311974.1 ENSMUSG00000132406 (from geneSymbol) uc335dfp.1 uc335dfp.1 
ENSMUST00000311976.1 ENSMUSG00000132407 ENSMUST00000311976.1 ENSMUSG00000132407 (from geneSymbol) uc335dfr.1 uc335dfr.1 
ENSMUST00000311977.1 ENSMUSG00000132408 ENSMUST00000311977.1 ENSMUSG00000132408 (from geneSymbol) uc335dfs.1 uc335dfs.1 
ENSMUST00000311981.1 ENSMUSG00000132409 ENSMUST00000311981.1 ENSMUSG00000132409 (from geneSymbol) uc335dfw.1 uc335dfw.1 
ENSMUST00000311983.1 ENSMUSG00000132410 ENSMUST00000311983.1 ENSMUSG00000132410 (from geneSymbol) uc335dfy.1 uc335dfy.1 
ENSMUST00000311985.1 ENSMUSG00000132411 ENSMUST00000311985.1 ENSMUSG00000132411 (from geneSymbol) uc335dga.1 uc335dga.1 
ENSMUST00000311986.1 ENSMUSG00000132412 ENSMUST00000311986.1 ENSMUSG00000132412 (from geneSymbol) uc335dgb.1 uc335dgb.1 
ENSMUST00000311990.1 ENSMUSG00000132413 ENSMUST00000311990.1 ENSMUSG00000132413 (from geneSymbol) uc335dgf.1 uc335dgf.1 
ENSMUST00000311991.1 ENSMUSG00000132414 ENSMUST00000311991.1 ENSMUSG00000132414 (from geneSymbol) uc335dgg.1 uc335dgg.1 
ENSMUST00000311992.1 ENSMUSG00000132415 ENSMUST00000311992.1 ENSMUSG00000132415 (from geneSymbol) uc335dgh.1 uc335dgh.1 
ENSMUST00000311996.1 Gm29676 ENSMUST00000311996.1 Gm29676 (from geneSymbol) AK035008 uc335dgl.1 uc335dgl.1 
ENSMUST00000312007.1 ENSMUSG00000132416 ENSMUST00000312007.1 ENSMUSG00000132416 (from geneSymbol) uc335dgw.1 uc335dgw.1 
ENSMUST00000312009.1 Gm36251 ENSMUST00000312009.1 Gm36251 (from geneSymbol) uc335dgy.1 uc335dgy.1 
ENSMUST00000312088.1 ENSMUSG00000144211 ENSMUST00000312088.1 ENSMUSG00000144211 (from geneSymbol) uc335djy.1 uc335djy.1 
ENSMUST00000312092.1 ENSMUSG00000132417 ENSMUST00000312092.1 ENSMUSG00000132417 (from geneSymbol) uc335dkc.1 uc335dkc.1 
ENSMUST00000312099.1 ENSMUSG00000132418 ENSMUST00000312099.1 ENSMUSG00000132418 (from geneSymbol) uc335dkj.1 uc335dkj.1 
ENSMUST00000312100.1 ENSMUSG00000132419 ENSMUST00000312100.1 ENSMUSG00000132419 (from geneSymbol) uc335dkk.1 uc335dkk.1 
ENSMUST00000312107.1 ENSMUSG00000132420 ENSMUST00000312107.1 ENSMUSG00000132420 (from geneSymbol) uc335dkr.1 uc335dkr.1 
ENSMUST00000312110.1 ENSMUSG00000132421 ENSMUST00000312110.1 ENSMUSG00000132421 (from geneSymbol) uc335dku.1 uc335dku.1 
ENSMUST00000312111.1 ENSMUSG00000132422 ENSMUST00000312111.1 ENSMUSG00000132422 (from geneSymbol) uc335dkv.1 uc335dkv.1 
ENSMUST00000312112.1 Gm15956 ENSMUST00000312112.1 Gm15956 (from geneSymbol) uc335dkw.1 uc335dkw.1 
ENSMUST00000312113.1 ENSMUSG00000132423 ENSMUST00000312113.1 ENSMUSG00000132423 (from geneSymbol) AK080325 uc335dkx.1 uc335dkx.1 
ENSMUST00000312114.1 ENSMUSG00000132424 ENSMUST00000312114.1 ENSMUSG00000132424 (from geneSymbol) uc335dky.1 uc335dky.1 
ENSMUST00000312115.1 ENSMUSG00000132425 ENSMUST00000312115.1 ENSMUSG00000132425 (from geneSymbol) uc335dkz.1 uc335dkz.1 
ENSMUST00000312143.1 Gm57273 ENSMUST00000312143.1 Gm57273 (from geneSymbol) uc335dmb.1 uc335dmb.1 
ENSMUST00000312162.1 ENSMUSG00000132426 ENSMUST00000312162.1 ENSMUSG00000132426 (from geneSymbol) uc335dmu.1 uc335dmu.1 
ENSMUST00000312165.1 ENSMUSG00000132427 ENSMUST00000312165.1 ENSMUSG00000132427 (from geneSymbol) uc335dmx.1 uc335dmx.1 
ENSMUST00000312166.1 ENSMUSG00000132428 ENSMUST00000312166.1 ENSMUSG00000132428 (from geneSymbol) uc335dmy.1 uc335dmy.1 
ENSMUST00000312167.1 ENSMUSG00000132429 ENSMUST00000312167.1 ENSMUSG00000132429 (from geneSymbol) uc335dmz.1 uc335dmz.1 
ENSMUST00000312168.1 ENSMUSG00000132430 ENSMUST00000312168.1 ENSMUSG00000132430 (from geneSymbol) uc335dna.1 uc335dna.1 
ENSMUST00000312169.1 9530077C14Rik ENSMUST00000312169.1 9530077C14Rik (from geneSymbol) uc335dnb.1 uc335dnb.1 
ENSMUST00000312177.1 ENSMUSG00000132431 ENSMUST00000312177.1 ENSMUSG00000132431 (from geneSymbol) uc335dnj.1 uc335dnj.1 
ENSMUST00000312180.1 Gm32679 ENSMUST00000312180.1 Gm32679 (from geneSymbol) uc335dnm.1 uc335dnm.1 
ENSMUST00000312184.1 Gm15046 ENSMUST00000312184.1 Gm15046 (from geneSymbol) uc335dnq.1 uc335dnq.1 
ENSMUST00000312186.1 ENSMUSG00000132432 ENSMUST00000312186.1 ENSMUSG00000132432 (from geneSymbol) uc335dns.1 uc335dns.1 
ENSMUST00000312187.1 ENSMUSG00000132433 ENSMUST00000312187.1 ENSMUSG00000132433 (from geneSymbol) uc335dnt.1 uc335dnt.1 
ENSMUST00000312191.1 ENSMUSG00000132434 ENSMUST00000312191.1 ENSMUSG00000132434 (from geneSymbol) uc335dnx.1 uc335dnx.1 
ENSMUST00000312194.1 ENSMUSG00000132435 ENSMUST00000312194.1 ENSMUSG00000132435 (from geneSymbol) uc335doa.1 uc335doa.1 
ENSMUST00000312199.1 ENSMUSG00000132436 ENSMUST00000312199.1 ENSMUSG00000132436 (from geneSymbol) uc335dof.1 uc335dof.1 
ENSMUST00000312220.1 ENSMUSG00000132437 ENSMUST00000312220.1 ENSMUSG00000132437 (from geneSymbol) uc335dpa.1 uc335dpa.1 
ENSMUST00000312223.1 ENSMUSG00000132438 ENSMUST00000312223.1 ENSMUSG00000132438 (from geneSymbol) uc335dpd.1 uc335dpd.1 
ENSMUST00000312231.1 ENSMUSG00000132439 ENSMUST00000312231.1 ENSMUSG00000132439 (from geneSymbol) FJ541075 uc335dpl.1 uc335dpl.1 
ENSMUST00000312240.1 ENSMUSG00000132440 ENSMUST00000312240.1 ENSMUSG00000132440 (from geneSymbol) AK133346 uc335dpu.1 uc335dpu.1 
ENSMUST00000312246.1 Altre ENSMUST00000312246.1 Altre (from geneSymbol) AK149394 uc335dqa.1 uc335dqa.1 
ENSMUST00000312279.1 ENSMUSG00000132441 ENSMUST00000312279.1 ENSMUSG00000132441 (from geneSymbol) uc335drg.1 uc335drg.1 
ENSMUST00000312280.1 ENSMUSG00000132442 ENSMUST00000312280.1 ENSMUSG00000132442 (from geneSymbol) uc335drh.1 uc335drh.1 
ENSMUST00000312281.1 ENSMUSG00000132443 ENSMUST00000312281.1 ENSMUSG00000132443 (from geneSymbol) uc335dri.1 uc335dri.1 
ENSMUST00000312283.1 Gm40576 ENSMUST00000312283.1 Gm40576 (from geneSymbol) uc335drk.1 uc335drk.1 
ENSMUST00000312319.1 ENSMUSG00000132444 ENSMUST00000312319.1 ENSMUSG00000132444 (from geneSymbol) uc335dsu.1 uc335dsu.1 
ENSMUST00000312320.1 ENSMUSG00000132445 ENSMUST00000312320.1 ENSMUSG00000132445 (from geneSymbol) uc335dsv.1 uc335dsv.1 
ENSMUST00000312321.1 ENSMUSG00000132446 ENSMUST00000312321.1 ENSMUSG00000132446 (from geneSymbol) uc335dsw.1 uc335dsw.1 
ENSMUST00000312330.1 ENSMUSG00000132447 ENSMUST00000312330.1 ENSMUSG00000132447 (from geneSymbol) uc335dtf.1 uc335dtf.1 
ENSMUST00000312332.1 ENSMUSG00000132448 ENSMUST00000312332.1 ENSMUSG00000132448 (from geneSymbol) uc335dth.1 uc335dth.1 
ENSMUST00000312335.1 ENSMUSG00000132449 ENSMUST00000312335.1 ENSMUSG00000132449 (from geneSymbol) uc335dtk.1 uc335dtk.1 
ENSMUST00000312336.1 ENSMUSG00000132450 ENSMUST00000312336.1 ENSMUSG00000132450 (from geneSymbol) uc335dtl.1 uc335dtl.1 
ENSMUST00000312338.1 ENSMUSG00000132451 ENSMUST00000312338.1 ENSMUSG00000132451 (from geneSymbol) uc335dtn.1 uc335dtn.1 
ENSMUST00000312339.1 Gm33684 ENSMUST00000312339.1 Gm33684 (from geneSymbol) uc335dto.1 uc335dto.1 
ENSMUST00000312343.1 ENSMUSG00000132452 ENSMUST00000312343.1 ENSMUSG00000132452 (from geneSymbol) uc335dts.1 uc335dts.1 
ENSMUST00000312344.1 ENSMUSG00000132453 ENSMUST00000312344.1 ENSMUSG00000132453 (from geneSymbol) LF250805 uc335dtt.1 uc335dtt.1 
ENSMUST00000312346.1 Gm4107 ENSMUST00000312346.1 Gm4107 (from geneSymbol) AK041437 uc335dtv.1 uc335dtv.1 
ENSMUST00000312353.1 ENSMUSG00000132454 ENSMUST00000312353.1 ENSMUSG00000132454 (from geneSymbol) uc335duc.1 uc335duc.1 
ENSMUST00000312355.1 ENSMUSG00000132455 ENSMUST00000312355.1 ENSMUSG00000132455 (from geneSymbol) uc335due.1 uc335due.1 
ENSMUST00000312357.1 Gm46133 ENSMUST00000312357.1 Gm46133 (from geneSymbol) uc335dug.1 uc335dug.1 
ENSMUST00000312374.1 ENSMUSG00000132456 ENSMUST00000312374.1 ENSMUSG00000132456 (from geneSymbol) uc335dux.1 uc335dux.1 
ENSMUST00000312375.1 ENSMUSG00000132457 ENSMUST00000312375.1 ENSMUSG00000132457 (from geneSymbol) uc335duy.1 uc335duy.1 
ENSMUST00000312376.1 ENSMUSG00000132458 ENSMUST00000312376.1 ENSMUSG00000132458 (from geneSymbol) uc335duz.1 uc335duz.1 
ENSMUST00000312387.1 ENSMUSG00000132459 ENSMUST00000312387.1 ENSMUSG00000132459 (from geneSymbol) uc335dvk.1 uc335dvk.1 
ENSMUST00000312390.1 ENSMUSG00000132460 ENSMUST00000312390.1 ENSMUSG00000132460 (from geneSymbol) uc335dvn.1 uc335dvn.1 
ENSMUST00000312391.1 ENSMUSG00000132461 ENSMUST00000312391.1 ENSMUSG00000132461 (from geneSymbol) uc335dvo.1 uc335dvo.1 
ENSMUST00000312392.1 ENSMUSG00000132462 ENSMUST00000312392.1 ENSMUSG00000132462 (from geneSymbol) uc335dvp.1 uc335dvp.1 
ENSMUST00000312393.1 ENSMUSG00000132463 ENSMUST00000312393.1 ENSMUSG00000132463 (from geneSymbol) uc335dvq.1 uc335dvq.1 
ENSMUST00000312398.1 ENSMUSG00000132464 ENSMUST00000312398.1 ENSMUSG00000132464 (from geneSymbol) uc335dvv.1 uc335dvv.1 
ENSMUST00000312401.1 Gm47766 ENSMUST00000312401.1 Gm47766 (from geneSymbol) uc335dvy.1 uc335dvy.1 
ENSMUST00000312408.1 ENSMUSG00000132465 ENSMUST00000312408.1 ENSMUSG00000132465 (from geneSymbol) uc335dwf.1 uc335dwf.1 
ENSMUST00000312409.1 Gm15862 ENSMUST00000312409.1 Gm15862 (from geneSymbol) uc335dwg.1 uc335dwg.1 
ENSMUST00000312410.1 ENSMUSG00000132466 ENSMUST00000312410.1 ENSMUSG00000132466 (from geneSymbol) uc335dwh.1 uc335dwh.1 
ENSMUST00000312411.1 ENSMUSG00000132467 ENSMUST00000312411.1 ENSMUSG00000132467 (from geneSymbol) uc335dwi.1 uc335dwi.1 
ENSMUST00000312412.1 ENSMUSG00000132468 ENSMUST00000312412.1 ENSMUSG00000132468 (from geneSymbol) uc335dwj.1 uc335dwj.1 
ENSMUST00000312415.1 Gm26834 ENSMUST00000312415.1 Gm26834 (from geneSymbol) AK144120 uc335dwm.1 uc335dwm.1 
ENSMUST00000312425.1 ENSMUSG00000132469 ENSMUST00000312425.1 ENSMUSG00000132469 (from geneSymbol) uc335dww.1 uc335dww.1 
ENSMUST00000312427.1 ENSMUSG00000132470 ENSMUST00000312427.1 ENSMUSG00000132470 (from geneSymbol) uc335dwy.1 uc335dwy.1 
ENSMUST00000312428.1 ENSMUSG00000132471 ENSMUST00000312428.1 ENSMUSG00000132471 (from geneSymbol) uc335dwz.1 uc335dwz.1 
ENSMUST00000312429.1 ENSMUSG00000132472 ENSMUST00000312429.1 ENSMUSG00000132472 (from geneSymbol) uc335dxa.1 uc335dxa.1 
ENSMUST00000312430.1 ENSMUSG00000132473 ENSMUST00000312430.1 ENSMUSG00000132473 (from geneSymbol) uc335dxb.1 uc335dxb.1 
ENSMUST00000312431.1 ENSMUSG00000132474 ENSMUST00000312431.1 ENSMUSG00000132474 (from geneSymbol) uc335dxc.1 uc335dxc.1 
ENSMUST00000312433.1 ENSMUSG00000132475 ENSMUST00000312433.1 ENSMUSG00000132475 (from geneSymbol) uc335dxe.1 uc335dxe.1 
ENSMUST00000312435.1 ENSMUSG00000132476 ENSMUST00000312435.1 ENSMUSG00000132476 (from geneSymbol) uc335dxg.1 uc335dxg.1 
ENSMUST00000312451.1 ENSMUSG00000132477 ENSMUST00000312451.1 ENSMUSG00000132477 (from geneSymbol) uc335dxw.1 uc335dxw.1 
ENSMUST00000312452.1 ENSMUSG00000132478 ENSMUST00000312452.1 ENSMUSG00000132478 (from geneSymbol) uc335dxx.1 uc335dxx.1 
ENSMUST00000312453.1 ENSMUSG00000132479 ENSMUST00000312453.1 ENSMUSG00000132479 (from geneSymbol) uc335dxy.1 uc335dxy.1 
ENSMUST00000312454.1 ENSMUSG00000132480 ENSMUST00000312454.1 ENSMUSG00000132480 (from geneSymbol) LF196031 uc335dxz.1 uc335dxz.1 
ENSMUST00000312455.1 ENSMUSG00000132481 ENSMUST00000312455.1 ENSMUSG00000132481 (from geneSymbol) uc335dya.1 uc335dya.1 
ENSMUST00000312456.1 ENSMUSG00000132482 ENSMUST00000312456.1 ENSMUSG00000132482 (from geneSymbol) uc335dyb.1 uc335dyb.1 
ENSMUST00000312465.1 ENSMUSG00000132483 ENSMUST00000312465.1 ENSMUSG00000132483 (from geneSymbol) uc335dyk.1 uc335dyk.1 
ENSMUST00000312468.1 ENSMUSG00000132484 ENSMUST00000312468.1 ENSMUSG00000132484 (from geneSymbol) uc335dyn.1 uc335dyn.1 
ENSMUST00000312469.1 ENSMUSG00000132485 ENSMUST00000312469.1 ENSMUSG00000132485 (from geneSymbol) uc335dyo.1 uc335dyo.1 
ENSMUST00000312471.1 ENSMUSG00000132486 ENSMUST00000312471.1 ENSMUSG00000132486 (from geneSymbol) uc335dyq.1 uc335dyq.1 
ENSMUST00000312472.1 ENSMUSG00000132487 ENSMUST00000312472.1 ENSMUSG00000132487 (from geneSymbol) uc335dyr.1 uc335dyr.1 
ENSMUST00000312475.1 Gm15234 ENSMUST00000312475.1 Gm15234 (from geneSymbol) KY467939 uc335dyu.1 uc335dyu.1 
ENSMUST00000312486.1 ENSMUSG00000132488 ENSMUST00000312486.1 ENSMUSG00000132488 (from geneSymbol) uc335dzf.1 uc335dzf.1 
ENSMUST00000312487.1 ENSMUSG00000132489 ENSMUST00000312487.1 ENSMUSG00000132489 (from geneSymbol) uc335dzg.1 uc335dzg.1 
ENSMUST00000312488.1 ENSMUSG00000132490 ENSMUST00000312488.1 ENSMUSG00000132490 (from geneSymbol) uc335dzh.1 uc335dzh.1 
ENSMUST00000312489.1 ENSMUSG00000132491 ENSMUST00000312489.1 ENSMUSG00000132491 (from geneSymbol) uc335dzi.1 uc335dzi.1 
ENSMUST00000312494.1 ENSMUSG00000132492 ENSMUST00000312494.1 ENSMUSG00000132492 (from geneSymbol) uc335dzn.1 uc335dzn.1 
ENSMUST00000312495.1 ENSMUSG00000132493 ENSMUST00000312495.1 ENSMUSG00000132493 (from geneSymbol) uc335dzo.1 uc335dzo.1 
ENSMUST00000312506.1 ENSMUSG00000132494 ENSMUST00000312506.1 ENSMUSG00000132494 (from geneSymbol) uc335dzz.1 uc335dzz.1 
ENSMUST00000312511.1 ENSMUSG00000132495 ENSMUST00000312511.1 ENSMUSG00000132495 (from geneSymbol) uc335eae.1 uc335eae.1 
ENSMUST00000312525.1 ENSMUSG00000132496 ENSMUST00000312525.1 ENSMUSG00000132496 (from geneSymbol) uc335eas.1 uc335eas.1 
ENSMUST00000312527.1 ENSMUSG00000132497 ENSMUST00000312527.1 ENSMUSG00000132497 (from geneSymbol) uc335eau.1 uc335eau.1 
ENSMUST00000312528.1 Gm38991 ENSMUST00000312528.1 Gm38991 (from geneSymbol) uc335eav.1 uc335eav.1 
ENSMUST00000312534.1 ENSMUSG00000132498 ENSMUST00000312534.1 ENSMUSG00000132498 (from geneSymbol) BC099537 uc335ebb.1 uc335ebb.1 
ENSMUST00000312540.1 ENSMUSG00000132499 ENSMUST00000312540.1 ENSMUSG00000132499 (from geneSymbol) uc335ebh.1 uc335ebh.1 
ENSMUST00000312543.1 Gm32954 ENSMUST00000312543.1 Gm32954 (from geneSymbol) uc335ebk.1 uc335ebk.1 
ENSMUST00000312548.1 ENSMUSG00000132500 ENSMUST00000312548.1 ENSMUSG00000132500 (from geneSymbol) uc335ebp.1 uc335ebp.1 
ENSMUST00000312556.1 ENSMUSG00000132501 ENSMUST00000312556.1 ENSMUSG00000132501 (from geneSymbol) uc335ebx.1 uc335ebx.1 
ENSMUST00000312557.1 ENSMUSG00000132502 ENSMUST00000312557.1 ENSMUSG00000132502 (from geneSymbol) uc335eby.1 uc335eby.1 
ENSMUST00000312558.1 ENSMUSG00000132503 ENSMUST00000312558.1 ENSMUSG00000132503 (from geneSymbol) uc335ebz.1 uc335ebz.1 
ENSMUST00000312563.1 Gm16551 ENSMUST00000312563.1 Gm16551 (from geneSymbol) AK050237 uc335ecc.1 uc335ecc.1 
ENSMUST00000312593.1 ENSMUSG00000132505 ENSMUST00000312593.1 ENSMUSG00000132505 (from geneSymbol) uc335edf.1 uc335edf.1 
ENSMUST00000312594.1 ENSMUSG00000132506 ENSMUST00000312594.1 ENSMUSG00000132506 (from geneSymbol) uc335edg.1 uc335edg.1 
ENSMUST00000312595.1 ENSMUSG00000132507 ENSMUST00000312595.1 ENSMUSG00000132507 (from geneSymbol) uc335edh.1 uc335edh.1 
ENSMUST00000312599.1 2010007H06Rik ENSMUST00000312599.1 2010007H06Rik (from geneSymbol) uc335edl.1 uc335edl.1 
ENSMUST00000312613.1 ENSMUSG00000132508 ENSMUST00000312613.1 ENSMUSG00000132508 (from geneSymbol) uc335edz.1 uc335edz.1 
ENSMUST00000312614.1 ENSMUSG00000132509 ENSMUST00000312614.1 ENSMUSG00000132509 (from geneSymbol) uc335eea.1 uc335eea.1 
ENSMUST00000312634.1 Gm33466 ENSMUST00000312634.1 Gm33466 (from geneSymbol) uc335eeu.1 uc335eeu.1 
ENSMUST00000312655.1 ENSMUSG00000132510 ENSMUST00000312655.1 ENSMUSG00000132510 (from geneSymbol) uc335efp.1 uc335efp.1 
ENSMUST00000312656.1 ENSMUSG00000132511 ENSMUST00000312656.1 ENSMUSG00000132511 (from geneSymbol) uc335efq.1 uc335efq.1 
ENSMUST00000312659.1 ENSMUSG00000132512 ENSMUST00000312659.1 ENSMUSG00000132512 (from geneSymbol) uc335eft.1 uc335eft.1 
ENSMUST00000312660.1 ENSMUSG00000132513 ENSMUST00000312660.1 ENSMUSG00000132513 (from geneSymbol) uc335efu.1 uc335efu.1 
ENSMUST00000312661.1 ENSMUSG00000132514 ENSMUST00000312661.1 ENSMUSG00000132514 (from geneSymbol) uc335efv.1 uc335efv.1 
ENSMUST00000312662.1 ENSMUSG00000132515 ENSMUST00000312662.1 ENSMUSG00000132515 (from geneSymbol) uc335efw.1 uc335efw.1 
ENSMUST00000312697.1 ENSMUSG00000132516 ENSMUST00000312697.1 ENSMUSG00000132516 (from geneSymbol) uc335efx.1 uc335efx.1 
ENSMUST00000312698.1 ENSMUSG00000132517 ENSMUST00000312698.1 ENSMUSG00000132517 (from geneSymbol) uc335efy.1 uc335efy.1 
ENSMUST00000312699.1 ENSMUSG00000132518 ENSMUST00000312699.1 ENSMUSG00000132518 (from geneSymbol) uc335efz.1 uc335efz.1 
ENSMUST00000312700.1 ENSMUSG00000132519 ENSMUST00000312700.1 ENSMUSG00000132519 (from geneSymbol) uc335ega.1 uc335ega.1 
ENSMUST00000312723.1 ENSMUSG00000132520 ENSMUST00000312723.1 ENSMUSG00000132520 (from geneSymbol) uc335egx.1 uc335egx.1 
ENSMUST00000312725.1 ENSMUSG00000132521 ENSMUST00000312725.1 ENSMUSG00000132521 (from geneSymbol) uc335egz.1 uc335egz.1 
ENSMUST00000312726.1 ENSMUSG00000132522 ENSMUST00000312726.1 ENSMUSG00000132522 (from geneSymbol) uc335eha.1 uc335eha.1 
ENSMUST00000312732.1 ENSMUSG00000132523 ENSMUST00000312732.1 ENSMUSG00000132523 (from geneSymbol) uc335ehg.1 uc335ehg.1 
ENSMUST00000312735.1 ENSMUSG00000132524 ENSMUST00000312735.1 ENSMUSG00000132524 (from geneSymbol) uc335ehj.1 uc335ehj.1 
ENSMUST00000312736.1 ENSMUSG00000132525 ENSMUST00000312736.1 ENSMUSG00000132525 (from geneSymbol) uc335ehk.1 uc335ehk.1 
ENSMUST00000312737.1 ENSMUSG00000132526 ENSMUST00000312737.1 ENSMUSG00000132526 (from geneSymbol) uc335ehl.1 uc335ehl.1 
ENSMUST00000312741.1 ENSMUSG00000132527 ENSMUST00000312741.1 ENSMUSG00000132527 (from geneSymbol) uc335ehp.1 uc335ehp.1 
ENSMUST00000312742.1 ENSMUSG00000132528 ENSMUST00000312742.1 ENSMUSG00000132528 (from geneSymbol) uc335ehq.1 uc335ehq.1 
ENSMUST00000312743.1 ENSMUSG00000132529 ENSMUST00000312743.1 ENSMUSG00000132529 (from geneSymbol) AK006687 uc335ehr.1 uc335ehr.1 
ENSMUST00000312744.1 ENSMUSG00000132530 ENSMUST00000312744.1 ENSMUSG00000132530 (from geneSymbol) uc335ehs.1 uc335ehs.1 
ENSMUST00000312747.1 ENSMUSG00000132531 ENSMUST00000312747.1 ENSMUSG00000132531 (from geneSymbol) uc335ehv.1 uc335ehv.1 
ENSMUST00000312748.1 ENSMUSG00000132532 ENSMUST00000312748.1 ENSMUSG00000132532 (from geneSymbol) uc335ehw.1 uc335ehw.1 
ENSMUST00000312749.1 Gm33630 ENSMUST00000312749.1 Gm33630 (from geneSymbol) uc335ehx.1 uc335ehx.1 
ENSMUST00000312752.1 ENSMUSG00000132533 ENSMUST00000312752.1 ENSMUSG00000132533 (from geneSymbol) uc335eia.1 uc335eia.1 
ENSMUST00000312754.1 ENSMUSG00000132534 ENSMUST00000312754.1 ENSMUSG00000132534 (from geneSymbol) uc335eic.1 uc335eic.1 
ENSMUST00000312763.1 ENSMUSG00000132535 ENSMUST00000312763.1 ENSMUSG00000132535 (from geneSymbol) uc335eil.1 uc335eil.1 
ENSMUST00000312764.1 ENSMUSG00000132536 ENSMUST00000312764.1 ENSMUSG00000132536 (from geneSymbol) uc335eim.1 uc335eim.1 
ENSMUST00000312765.1 ENSMUSG00000132537 ENSMUST00000312765.1 ENSMUSG00000132537 (from geneSymbol) uc335ein.1 uc335ein.1 
ENSMUST00000312766.1 ENSMUSG00000132538 ENSMUST00000312766.1 ENSMUSG00000132538 (from geneSymbol) uc335eio.1 uc335eio.1 
ENSMUST00000312767.1 ENSMUSG00000132539 ENSMUST00000312767.1 ENSMUSG00000132539 (from geneSymbol) uc335eip.1 uc335eip.1 
ENSMUST00000312768.1 ENSMUSG00000132540 ENSMUST00000312768.1 ENSMUSG00000132540 (from geneSymbol) uc335eiq.1 uc335eiq.1 
ENSMUST00000312772.1 ENSMUSG00000121791 ENSMUST00000312772.1 ENSMUSG00000121791 (from geneSymbol) AK017151 uc335eiu.1 uc335eiu.1 
ENSMUST00000312781.1 ENSMUSG00000132541 ENSMUST00000312781.1 ENSMUSG00000132541 (from geneSymbol) uc335ejd.1 uc335ejd.1 
ENSMUST00000312785.1 Gm56559 ENSMUST00000312785.1 Gm56559 (from geneSymbol) uc335ejh.1 uc335ejh.1 
ENSMUST00000312796.1 ENSMUSG00000132542 ENSMUST00000312796.1 ENSMUSG00000132542 (from geneSymbol) uc335ejs.1 uc335ejs.1 
ENSMUST00000312798.1 ENSMUSG00000132543 ENSMUST00000312798.1 ENSMUSG00000132543 (from geneSymbol) uc335eju.1 uc335eju.1 
ENSMUST00000312801.1 ENSMUSG00000132544 ENSMUST00000312801.1 ENSMUSG00000132544 (from geneSymbol) uc335ejx.1 uc335ejx.1 
ENSMUST00000312821.1 Gm30093 ENSMUST00000312821.1 Gm30093 (from geneSymbol) uc335ekr.1 uc335ekr.1 
ENSMUST00000312837.1 ENSMUSG00000132545 ENSMUST00000312837.1 ENSMUSG00000132545 (from geneSymbol) uc335elh.1 uc335elh.1 
ENSMUST00000312838.1 ENSMUSG00000132546 ENSMUST00000312838.1 ENSMUSG00000132546 (from geneSymbol) uc335eli.1 uc335eli.1 
ENSMUST00000312841.1 ENSMUSG00000132547 ENSMUST00000312841.1 ENSMUSG00000132547 (from geneSymbol) uc335ell.1 uc335ell.1 
ENSMUST00000312843.1 ENSMUSG00000132548 ENSMUST00000312843.1 ENSMUSG00000132548 (from geneSymbol) uc335eln.1 uc335eln.1 
ENSMUST00000312844.1 ENSMUSG00000132549 ENSMUST00000312844.1 ENSMUSG00000132549 (from geneSymbol) uc335elo.1 uc335elo.1 
ENSMUST00000312845.1 ENSMUSG00000132550 ENSMUST00000312845.1 ENSMUSG00000132550 (from geneSymbol) uc335elp.1 uc335elp.1 
ENSMUST00000312846.1 ENSMUSG00000132551 ENSMUST00000312846.1 ENSMUSG00000132551 (from geneSymbol) uc335elq.1 uc335elq.1 
ENSMUST00000312847.1 ENSMUSG00000132552 ENSMUST00000312847.1 ENSMUSG00000132552 (from geneSymbol) uc335elr.1 uc335elr.1 
ENSMUST00000312849.1 ENSMUSG00000132553 ENSMUST00000312849.1 ENSMUSG00000132553 (from geneSymbol) uc335elt.1 uc335elt.1 
ENSMUST00000312857.1 Gm28076 ENSMUST00000312857.1 Gm28076 (from geneSymbol) uc335emb.1 uc335emb.1 
ENSMUST00000312905.1 ENSMUSG00000132554 ENSMUST00000312905.1 ENSMUSG00000132554 (from geneSymbol) uc335env.1 uc335env.1 
ENSMUST00000312907.1 ENSMUSG00000132555 ENSMUST00000312907.1 ENSMUSG00000132555 (from geneSymbol) uc335enx.1 uc335enx.1 
ENSMUST00000312915.1 Gm16556 ENSMUST00000312915.1 Gm16556 (from geneSymbol) KY468106 uc335eof.1 uc335eof.1 
ENSMUST00000312922.1 ENSMUSG00000132556 ENSMUST00000312922.1 ENSMUSG00000132556 (from geneSymbol) uc335eom.1 uc335eom.1 
ENSMUST00000312923.1 ENSMUSG00000132557 ENSMUST00000312923.1 ENSMUSG00000132557 (from geneSymbol) uc335eon.1 uc335eon.1 
ENSMUST00000312924.1 ENSMUSG00000132558 ENSMUST00000312924.1 ENSMUSG00000132558 (from geneSymbol) uc335eoo.1 uc335eoo.1 
ENSMUST00000312925.1 ENSMUSG00000132559 ENSMUST00000312925.1 ENSMUSG00000132559 (from geneSymbol) uc335eop.1 uc335eop.1 
ENSMUST00000312926.1 Gm45330 ENSMUST00000312926.1 Gm45330 (from geneSymbol) uc335eoq.1 uc335eoq.1 
ENSMUST00000312930.1 Gm36486 ENSMUST00000312930.1 Gm36486 (from geneSymbol) AK047301 uc335eou.1 uc335eou.1 
ENSMUST00000312940.1 ENSMUSG00000132560 ENSMUST00000312940.1 ENSMUSG00000132560 (from geneSymbol) uc335epe.1 uc335epe.1 
ENSMUST00000312941.1 ENSMUSG00000132561 ENSMUST00000312941.1 ENSMUSG00000132561 (from geneSymbol) uc335epf.1 uc335epf.1 
ENSMUST00000312942.1 ENSMUSG00000132562 ENSMUST00000312942.1 ENSMUSG00000132562 (from geneSymbol) LF200970 uc335epg.1 uc335epg.1 
ENSMUST00000312943.1 ENSMUSG00000132563 ENSMUST00000312943.1 ENSMUSG00000132563 (from geneSymbol) uc335eph.1 uc335eph.1 
ENSMUST00000312944.1 ENSMUSG00000132564 ENSMUST00000312944.1 ENSMUSG00000132564 (from geneSymbol) uc335epi.1 uc335epi.1 
ENSMUST00000312947.1 ENSMUSG00000132565 ENSMUST00000312947.1 ENSMUSG00000132565 (from geneSymbol) uc335epl.1 uc335epl.1 
ENSMUST00000312952.1 ENSMUSG00000132566 ENSMUST00000312952.1 ENSMUSG00000132566 (from geneSymbol) uc335epq.1 uc335epq.1 
ENSMUST00000312954.1 ENSMUSG00000132567 ENSMUST00000312954.1 ENSMUSG00000132567 (from geneSymbol) uc335eps.1 uc335eps.1 
ENSMUST00000312955.1 ENSMUSG00000132568 ENSMUST00000312955.1 ENSMUSG00000132568 (from geneSymbol) uc335ept.1 uc335ept.1 
ENSMUST00000312956.1 ENSMUSG00000132569 ENSMUST00000312956.1 ENSMUSG00000132569 (from geneSymbol) uc335epu.1 uc335epu.1 
ENSMUST00000312957.1 ENSMUSG00000132570 ENSMUST00000312957.1 ENSMUSG00000132570 (from geneSymbol) uc335epv.1 uc335epv.1 
ENSMUST00000312959.1 ENSMUSG00000132571 ENSMUST00000312959.1 ENSMUSG00000132571 (from geneSymbol) uc335epx.1 uc335epx.1 
ENSMUST00000312961.1 ENSMUSG00000132572 ENSMUST00000312961.1 ENSMUSG00000132572 (from geneSymbol) uc335epz.1 uc335epz.1 
ENSMUST00000312962.1 ENSMUSG00000132573 ENSMUST00000312962.1 ENSMUSG00000132573 (from geneSymbol) uc335eqa.1 uc335eqa.1 
ENSMUST00000312965.1 2900045O20Rik ENSMUST00000312965.1 2900045O20Rik (from geneSymbol) AK013651 uc335eqd.1 uc335eqd.1 
ENSMUST00000312968.1 ENSMUSG00000132575 ENSMUST00000312968.1 ENSMUSG00000132575 (from geneSymbol) uc335eqf.1 uc335eqf.1 
ENSMUST00000312969.1 ENSMUSG00000132576 ENSMUST00000312969.1 ENSMUSG00000132576 (from geneSymbol) uc335eqg.1 uc335eqg.1 
ENSMUST00000312973.1 ENSMUSG00000132577 ENSMUST00000312973.1 ENSMUSG00000132577 (from geneSymbol) uc335eqj.1 uc335eqj.1 
ENSMUST00000312974.1 ENSMUSG00000132578 ENSMUST00000312974.1 ENSMUSG00000132578 (from geneSymbol) uc335eqk.1 uc335eqk.1 
ENSMUST00000312984.1 ENSMUSG00000132579 ENSMUST00000312984.1 ENSMUSG00000132579 (from geneSymbol) uc335equ.1 uc335equ.1 
ENSMUST00000312985.1 ENSMUSG00000132580 ENSMUST00000312985.1 ENSMUSG00000132580 (from geneSymbol) uc335eqv.1 uc335eqv.1 
ENSMUST00000312986.1 ENSMUSG00000132581 ENSMUST00000312986.1 ENSMUSG00000132581 (from geneSymbol) uc335eqw.1 uc335eqw.1 
ENSMUST00000312988.1 ENSMUSG00000132582 ENSMUST00000312988.1 ENSMUSG00000132582 (from geneSymbol) uc335eqy.1 uc335eqy.1 
ENSMUST00000312989.1 ENSMUSG00000132583 ENSMUST00000312989.1 ENSMUSG00000132583 (from geneSymbol) uc335eqz.1 uc335eqz.1 
ENSMUST00000312991.1 ENSMUSG00000132584 ENSMUST00000312991.1 ENSMUSG00000132584 (from geneSymbol) uc335erb.1 uc335erb.1 
ENSMUST00000312993.1 ENSMUSG00000132585 ENSMUST00000312993.1 ENSMUSG00000132585 (from geneSymbol) uc335erd.1 uc335erd.1 
ENSMUST00000312998.1 ENSMUSG00000132586 ENSMUST00000312998.1 ENSMUSG00000132586 (from geneSymbol) uc335eri.1 uc335eri.1 
ENSMUST00000312999.1 ENSMUSG00000132587 ENSMUST00000312999.1 ENSMUSG00000132587 (from geneSymbol) uc335erj.1 uc335erj.1 
ENSMUST00000313004.1 ENSMUSG00000132588 ENSMUST00000313004.1 ENSMUSG00000132588 (from geneSymbol) uc335ero.1 uc335ero.1 
ENSMUST00000313005.1 ENSMUSG00000132589 ENSMUST00000313005.1 ENSMUSG00000132589 (from geneSymbol) uc335erp.1 uc335erp.1 
ENSMUST00000313007.1 ENSMUSG00000132590 ENSMUST00000313007.1 ENSMUSG00000132590 (from geneSymbol) uc335err.1 uc335err.1 
ENSMUST00000313052.1 ENSMUSG00000132591 ENSMUST00000313052.1 ENSMUSG00000132591 (from geneSymbol) AK132189 uc335etk.1 uc335etk.1 
ENSMUST00000313054.1 ENSMUSG00000132592 ENSMUST00000313054.1 ENSMUSG00000132592 (from geneSymbol) uc335etl.1 uc335etl.1 
ENSMUST00000313058.1 ENSMUSG00000132593 ENSMUST00000313058.1 ENSMUSG00000132593 (from geneSymbol) uc335eto.1 uc335eto.1 
ENSMUST00000313059.1 ENSMUSG00000132594 ENSMUST00000313059.1 ENSMUSG00000132594 (from geneSymbol) uc335etp.1 uc335etp.1 
ENSMUST00000313060.1 ENSMUSG00000132595 ENSMUST00000313060.1 ENSMUSG00000132595 (from geneSymbol) uc335etq.1 uc335etq.1 
ENSMUST00000313062.1 ENSMUSG00000132596 ENSMUST00000313062.1 ENSMUSG00000132596 (from geneSymbol) uc335ets.1 uc335ets.1 
ENSMUST00000313063.1 ENSMUSG00000132597 ENSMUST00000313063.1 ENSMUSG00000132597 (from geneSymbol) uc335ett.1 uc335ett.1 
ENSMUST00000313066.1 ENSMUSG00000132598 ENSMUST00000313066.1 ENSMUSG00000132598 (from geneSymbol) uc335etw.1 uc335etw.1 
ENSMUST00000313071.1 ENSMUSG00000132599 ENSMUST00000313071.1 ENSMUSG00000132599 (from geneSymbol) uc335eub.1 uc335eub.1 
ENSMUST00000313075.1 ENSMUSG00000132601 ENSMUST00000313075.1 ENSMUSG00000132601 (from geneSymbol) uc335euc.1 uc335euc.1 
ENSMUST00000313078.1 ENSMUSG00000132602 ENSMUST00000313078.1 ENSMUSG00000132602 (from geneSymbol) uc335eue.1 uc335eue.1 
ENSMUST00000313079.1 Gm28075 ENSMUST00000313079.1 Gm28075 (from geneSymbol) uc335euf.1 uc335euf.1 
ENSMUST00000313086.1 ENSMUSG00000132603 ENSMUST00000313086.1 ENSMUSG00000132603 (from geneSymbol) uc335eum.1 uc335eum.1 
ENSMUST00000313087.1 ENSMUSG00000132604 ENSMUST00000313087.1 ENSMUSG00000132604 (from geneSymbol) uc335eun.1 uc335eun.1 
ENSMUST00000313088.1 ENSMUSG00000132605 ENSMUST00000313088.1 ENSMUSG00000132605 (from geneSymbol) uc335euo.1 uc335euo.1 
ENSMUST00000313090.1 ENSMUSG00000132607 ENSMUST00000313090.1 ENSMUSG00000132607 (from geneSymbol) uc335eup.1 uc335eup.1 
ENSMUST00000313091.1 ENSMUSG00000132608 ENSMUST00000313091.1 ENSMUSG00000132608 (from geneSymbol) uc335euq.1 uc335euq.1 
ENSMUST00000313093.1 ENSMUSG00000132609 ENSMUST00000313093.1 ENSMUSG00000132609 (from geneSymbol) uc335eus.1 uc335eus.1 
ENSMUST00000313102.1 ENSMUSG00000132610 ENSMUST00000313102.1 ENSMUSG00000132610 (from geneSymbol) uc335evb.1 uc335evb.1 
ENSMUST00000313103.1 Gm36199 ENSMUST00000313103.1 Gm36199 (from geneSymbol) uc335evc.1 uc335evc.1 
ENSMUST00000313146.1 ENSMUSG00000132611 ENSMUST00000313146.1 ENSMUSG00000132611 (from geneSymbol) AK133422 uc335ewt.1 uc335ewt.1 
ENSMUST00000313149.1 ENSMUSG00000132612 ENSMUST00000313149.1 ENSMUSG00000132612 (from geneSymbol) uc335eww.1 uc335eww.1 
ENSMUST00000313151.1 ENSMUSG00000132613 ENSMUST00000313151.1 ENSMUSG00000132613 (from geneSymbol) uc335ewy.1 uc335ewy.1 
ENSMUST00000313153.1 ENSMUSG00000132614 ENSMUST00000313153.1 ENSMUSG00000132614 (from geneSymbol) uc335exa.1 uc335exa.1 
ENSMUST00000313161.1 ENSMUSG00000132615 ENSMUST00000313161.1 ENSMUSG00000132615 (from geneSymbol) uc335exg.1 uc335exg.1 
ENSMUST00000313162.1 ENSMUSG00000132616 ENSMUST00000313162.1 ENSMUSG00000132616 (from geneSymbol) uc335exh.1 uc335exh.1 
ENSMUST00000313163.1 ENSMUSG00000132617 ENSMUST00000313163.1 ENSMUSG00000132617 (from geneSymbol) uc335exi.1 uc335exi.1 
ENSMUST00000313166.1 ENSMUSG00000132618 ENSMUST00000313166.1 ENSMUSG00000132618 (from geneSymbol) uc335exl.1 uc335exl.1 
ENSMUST00000313169.1 Gm35611 ENSMUST00000313169.1 Gm35611 (from geneSymbol) uc335exo.1 uc335exo.1 
ENSMUST00000313183.1 ENSMUSG00000132619 ENSMUST00000313183.1 ENSMUSG00000132619 (from geneSymbol) uc335eyc.1 uc335eyc.1 
ENSMUST00000313185.1 ENSMUSG00000121901 ENSMUST00000313185.1 ENSMUSG00000121901 (from geneSymbol) uc335eye.1 uc335eye.1 
ENSMUST00000313203.1 ENSMUSG00000132620 ENSMUST00000313203.1 ENSMUSG00000132620 (from geneSymbol) uc335eyw.1 uc335eyw.1 
ENSMUST00000313214.1 ENSMUSG00000132621 ENSMUST00000313214.1 ENSMUSG00000132621 (from geneSymbol) uc335ezh.1 uc335ezh.1 
ENSMUST00000313216.1 ENSMUSG00000132622 ENSMUST00000313216.1 ENSMUSG00000132622 (from geneSymbol) uc335ezj.1 uc335ezj.1 
ENSMUST00000313217.1 ENSMUSG00000132623 ENSMUST00000313217.1 ENSMUSG00000132623 (from geneSymbol) uc335ezk.1 uc335ezk.1 
ENSMUST00000313218.1 ENSMUSG00000132624 ENSMUST00000313218.1 ENSMUSG00000132624 (from geneSymbol) uc335ezl.1 uc335ezl.1 
ENSMUST00000313219.1 ENSMUSG00000132625 ENSMUST00000313219.1 ENSMUSG00000132625 (from geneSymbol) uc335ezm.1 uc335ezm.1 
ENSMUST00000313222.1 ENSMUSG00000132627 ENSMUST00000313222.1 ENSMUSG00000132627 (from geneSymbol) uc335ezo.1 uc335ezo.1 
ENSMUST00000313227.1 Gm19689 ENSMUST00000313227.1 Gm19689 (from geneSymbol) AK051223 uc335ezt.1 uc335ezt.1 
ENSMUST00000313274.1 ENSMUSG00000132628 ENSMUST00000313274.1 ENSMUSG00000132628 (from geneSymbol) uc335fbo.1 uc335fbo.1 
ENSMUST00000313281.1 Gm35208 ENSMUST00000313281.1 Gm35208 (from geneSymbol) uc335fbv.1 uc335fbv.1 
ENSMUST00000313295.1 ENSMUSG00000132629 ENSMUST00000313295.1 ENSMUSG00000132629 (from geneSymbol) uc335fcj.1 uc335fcj.1 
ENSMUST00000313296.1 ENSMUSG00000132630 ENSMUST00000313296.1 ENSMUSG00000132630 (from geneSymbol) uc335fck.1 uc335fck.1 
ENSMUST00000313297.1 ENSMUSG00000132631 ENSMUST00000313297.1 ENSMUSG00000132631 (from geneSymbol) uc335fcl.1 uc335fcl.1 
ENSMUST00000313299.1 ENSMUSG00000132632 ENSMUST00000313299.1 ENSMUSG00000132632 (from geneSymbol) uc335fcn.1 uc335fcn.1 
ENSMUST00000313301.1 ENSMUSG00000132633 ENSMUST00000313301.1 ENSMUSG00000132633 (from geneSymbol) uc335fcp.1 uc335fcp.1 
ENSMUST00000313302.1 ENSMUSG00000132634 ENSMUST00000313302.1 ENSMUSG00000132634 (from geneSymbol) uc335fcq.1 uc335fcq.1 
ENSMUST00000313307.1 ENSMUSG00000132635 ENSMUST00000313307.1 ENSMUSG00000132635 (from geneSymbol) uc335fcv.1 uc335fcv.1 
ENSMUST00000313309.1 Gm41787 ENSMUST00000313309.1 Gm41787 (from geneSymbol) uc335fcx.1 uc335fcx.1 
ENSMUST00000313316.1 ENSMUSG00000132636 ENSMUST00000313316.1 ENSMUSG00000132636 (from geneSymbol) uc335fdd.1 uc335fdd.1 
ENSMUST00000313317.1 Gm12408 ENSMUST00000313317.1 Gm12408 (from geneSymbol) AK044089 uc335fde.1 uc335fde.1 
ENSMUST00000313333.1 ENSMUSG00000132637 ENSMUST00000313333.1 ENSMUSG00000132637 (from geneSymbol) uc335fdu.1 uc335fdu.1 
ENSMUST00000313334.1 ENSMUSG00000132638 ENSMUST00000313334.1 ENSMUSG00000132638 (from geneSymbol) uc335fdv.1 uc335fdv.1 
ENSMUST00000313335.1 ENSMUSG00000132639 ENSMUST00000313335.1 ENSMUSG00000132639 (from geneSymbol) uc335fdw.1 uc335fdw.1 
ENSMUST00000313337.1 ENSMUSG00000132640 ENSMUST00000313337.1 ENSMUSG00000132640 (from geneSymbol) uc335fdy.1 uc335fdy.1 
ENSMUST00000313340.1 ENSMUSG00000132642 ENSMUST00000313340.1 ENSMUSG00000132642 (from geneSymbol) uc335fea.1 uc335fea.1 
ENSMUST00000313345.1 ENSMUSG00000132643 ENSMUST00000313345.1 ENSMUSG00000132643 (from geneSymbol) uc335fef.1 uc335fef.1 
ENSMUST00000313346.1 ENSMUSG00000132644 ENSMUST00000313346.1 ENSMUSG00000132644 (from geneSymbol) uc335feg.1 uc335feg.1 
ENSMUST00000313347.1 ENSMUSG00000132645 ENSMUST00000313347.1 ENSMUSG00000132645 (from geneSymbol) uc335feh.1 uc335feh.1 
ENSMUST00000313348.1 ENSMUSG00000132646 ENSMUST00000313348.1 ENSMUSG00000132646 (from geneSymbol) uc335fei.1 uc335fei.1 
ENSMUST00000313369.1 ENSMUSG00000132647 ENSMUST00000313369.1 ENSMUSG00000132647 (from geneSymbol) uc335ffc.1 uc335ffc.1 
ENSMUST00000313370.1 ENSMUSG00000132648 ENSMUST00000313370.1 ENSMUSG00000132648 (from geneSymbol) uc335ffd.1 uc335ffd.1 
ENSMUST00000313388.1 ENSMUSG00000132649 ENSMUST00000313388.1 ENSMUSG00000132649 (from geneSymbol) uc335ffv.1 uc335ffv.1 
ENSMUST00000313390.1 ENSMUSG00000132650 ENSMUST00000313390.1 ENSMUSG00000132650 (from geneSymbol) uc335ffx.1 uc335ffx.1 
ENSMUST00000313391.1 Gm16084 ENSMUST00000313391.1 Gm16084 (from geneSymbol) uc335ffy.1 uc335ffy.1 
ENSMUST00000313402.1 ENSMUSG00000132651 ENSMUST00000313402.1 ENSMUSG00000132651 (from geneSymbol) uc335fgj.1 uc335fgj.1 
ENSMUST00000313406.1 ENSMUSG00000132652 ENSMUST00000313406.1 ENSMUSG00000132652 (from geneSymbol) uc335fgn.1 uc335fgn.1 
ENSMUST00000313412.1 ENSMUSG00000132653 ENSMUST00000313412.1 ENSMUSG00000132653 (from geneSymbol) uc335fgt.1 uc335fgt.1 
ENSMUST00000313413.1 ENSMUSG00000132654 ENSMUST00000313413.1 ENSMUSG00000132654 (from geneSymbol) uc335fgu.1 uc335fgu.1 
ENSMUST00000313415.1 ENSMUSG00000132655 ENSMUST00000313415.1 ENSMUSG00000132655 (from geneSymbol) uc335fgw.1 uc335fgw.1 
ENSMUST00000313418.1 ENSMUSG00000132656 ENSMUST00000313418.1 ENSMUSG00000132656 (from geneSymbol) uc335fgz.1 uc335fgz.1 
ENSMUST00000313422.1 Gm10433 ENSMUST00000313422.1 Gm10433 (from geneSymbol) uc335fhd.1 uc335fhd.1 
ENSMUST00000313432.1 ENSMUSG00000132657 ENSMUST00000313432.1 ENSMUSG00000132657 (from geneSymbol) uc335fhn.1 uc335fhn.1 
ENSMUST00000313435.1 ENSMUSG00000132658 ENSMUST00000313435.1 ENSMUSG00000132658 (from geneSymbol) uc335fhq.1 uc335fhq.1 
ENSMUST00000313436.1 ENSMUSG00000132659 ENSMUST00000313436.1 ENSMUSG00000132659 (from geneSymbol) uc335fhr.1 uc335fhr.1 
ENSMUST00000313437.1 ENSMUSG00000132660 ENSMUST00000313437.1 ENSMUSG00000132660 (from geneSymbol) uc335fhs.1 uc335fhs.1 
ENSMUST00000313438.1 ENSMUSG00000132661 ENSMUST00000313438.1 ENSMUSG00000132661 (from geneSymbol) uc335fht.1 uc335fht.1 
ENSMUST00000313439.1 ENSMUSG00000132662 ENSMUST00000313439.1 ENSMUSG00000132662 (from geneSymbol) uc335fhu.1 uc335fhu.1 
ENSMUST00000313440.1 ENSMUSG00000132663 ENSMUST00000313440.1 ENSMUSG00000132663 (from geneSymbol) uc335fhv.1 uc335fhv.1 
ENSMUST00000313441.1 ENSMUSG00000132664 ENSMUST00000313441.1 ENSMUSG00000132664 (from geneSymbol) uc335fhw.1 uc335fhw.1 
ENSMUST00000313443.1 ENSMUSG00000132666 ENSMUST00000313443.1 ENSMUSG00000132666 (from geneSymbol) uc335fhx.1 uc335fhx.1 
ENSMUST00000313444.1 ENSMUSG00000132667 ENSMUST00000313444.1 ENSMUSG00000132667 (from geneSymbol) uc335fhy.1 uc335fhy.1 
ENSMUST00000313448.1 ENSMUSG00000132668 ENSMUST00000313448.1 ENSMUSG00000132668 (from geneSymbol) uc335fic.1 uc335fic.1 
ENSMUST00000313456.1 ENSMUSG00000132669 ENSMUST00000313456.1 ENSMUSG00000132669 (from geneSymbol) uc335fik.1 uc335fik.1 
ENSMUST00000313459.1 ENSMUSG00000132670 ENSMUST00000313459.1 ENSMUSG00000132670 (from geneSymbol) uc335fin.1 uc335fin.1 
ENSMUST00000313465.1 ENSMUSG00000132671 ENSMUST00000313465.1 ENSMUSG00000132671 (from geneSymbol) uc335fit.1 uc335fit.1 
ENSMUST00000313468.1 ENSMUSG00000132672 ENSMUST00000313468.1 ENSMUSG00000132672 (from geneSymbol) uc335fiw.1 uc335fiw.1 
ENSMUST00000313472.1 ENSMUSG00000132673 ENSMUST00000313472.1 ENSMUSG00000132673 (from geneSymbol) uc335fja.1 uc335fja.1 
ENSMUST00000313473.1 ENSMUSG00000132674 ENSMUST00000313473.1 ENSMUSG00000132674 (from geneSymbol) uc335fjb.1 uc335fjb.1 
ENSMUST00000313480.1 ENSMUSG00000132675 ENSMUST00000313480.1 ENSMUSG00000132675 (from geneSymbol) uc335fji.1 uc335fji.1 
ENSMUST00000313487.1 ENSMUSG00000132676 ENSMUST00000313487.1 ENSMUSG00000132676 (from geneSymbol) uc335fjp.1 uc335fjp.1 
ENSMUST00000313490.1 ENSMUSG00000132677 ENSMUST00000313490.1 ENSMUSG00000132677 (from geneSymbol) uc335fjs.1 uc335fjs.1 
ENSMUST00000313492.1 ENSMUSG00000132678 ENSMUST00000313492.1 ENSMUSG00000132678 (from geneSymbol) uc335fju.1 uc335fju.1 
ENSMUST00000313494.1 ENSMUSG00000132679 ENSMUST00000313494.1 ENSMUSG00000132679 (from geneSymbol) uc335fjw.1 uc335fjw.1 
ENSMUST00000313495.1 ENSMUSG00000132680 ENSMUST00000313495.1 ENSMUSG00000132680 (from geneSymbol) uc335fjx.1 uc335fjx.1 
ENSMUST00000313497.1 Gm46597 ENSMUST00000313497.1 Gm46597 (from geneSymbol) uc335fjz.1 uc335fjz.1 
ENSMUST00000313499.1 ENSMUSG00000132681 ENSMUST00000313499.1 ENSMUSG00000132681 (from geneSymbol) uc335fkb.1 uc335fkb.1 
ENSMUST00000313500.1 Gm5645 ENSMUST00000313500.1 Gm5645 (from geneSymbol) uc335fkc.1 uc335fkc.1 
ENSMUST00000313505.1 Gm15104 ENSMUST00000313505.1 Gm15104 (from geneSymbol) BC099570 uc335fkh.1 uc335fkh.1 
ENSMUST00000313511.1 ENSMUSG00000132683 ENSMUST00000313511.1 ENSMUSG00000132683 (from geneSymbol) uc335fkn.1 uc335fkn.1 
ENSMUST00000313516.1 ENSMUSG00000132684 ENSMUST00000313516.1 ENSMUSG00000132684 (from geneSymbol) uc335fks.1 uc335fks.1 
ENSMUST00000313517.1 ENSMUSG00000132685 ENSMUST00000313517.1 ENSMUSG00000132685 (from geneSymbol) DQ703715 uc335fkt.1 uc335fkt.1 
ENSMUST00000313518.1 ENSMUSG00000132686 ENSMUST00000313518.1 ENSMUSG00000132686 (from geneSymbol) uc335fku.1 uc335fku.1 
ENSMUST00000313519.1 ENSMUSG00000132687 ENSMUST00000313519.1 ENSMUSG00000132687 (from geneSymbol) uc335fkv.1 uc335fkv.1 
ENSMUST00000313520.1 ENSMUSG00000132688 ENSMUST00000313520.1 ENSMUSG00000132688 (from geneSymbol) uc335fkw.1 uc335fkw.1 
ENSMUST00000313523.1 ENSMUSG00000132690 ENSMUST00000313523.1 ENSMUSG00000132690 (from geneSymbol) uc335fky.1 uc335fky.1 
ENSMUST00000313524.1 ENSMUSG00000132691 ENSMUST00000313524.1 ENSMUSG00000132691 (from geneSymbol) uc335fkz.1 uc335fkz.1 
ENSMUST00000313525.1 ENSMUSG00000132692 ENSMUST00000313525.1 ENSMUSG00000132692 (from geneSymbol) uc335fla.1 uc335fla.1 
ENSMUST00000313526.1 Gm4894 ENSMUST00000313526.1 Gm4894 (from geneSymbol) BC132633 uc335flb.1 uc335flb.1 
ENSMUST00000313532.1 ENSMUSG00000132693 ENSMUST00000313532.1 ENSMUSG00000132693 (from geneSymbol) uc335flh.1 uc335flh.1 
ENSMUST00000313533.1 ENSMUSG00000132694 ENSMUST00000313533.1 ENSMUSG00000132694 (from geneSymbol) uc335fli.1 uc335fli.1 
ENSMUST00000313535.1 ENSMUSG00000132695 ENSMUST00000313535.1 ENSMUSG00000132695 (from geneSymbol) uc335flk.1 uc335flk.1 
ENSMUST00000313537.1 ENSMUSG00000132696 ENSMUST00000313537.1 ENSMUSG00000132696 (from geneSymbol) uc335flm.1 uc335flm.1 
ENSMUST00000313538.1 ENSMUSG00000132697 ENSMUST00000313538.1 ENSMUSG00000132697 (from geneSymbol) uc335fln.1 uc335fln.1 
ENSMUST00000313543.1 ENSMUSG00000132698 ENSMUST00000313543.1 ENSMUSG00000132698 (from geneSymbol) uc335fls.1 uc335fls.1 
ENSMUST00000313544.1 ENSMUSG00000132699 ENSMUST00000313544.1 ENSMUSG00000132699 (from geneSymbol) uc335flt.1 uc335flt.1 
ENSMUST00000313550.1 Gm36263 ENSMUST00000313550.1 Gm36263 (from geneSymbol) uc335flz.1 uc335flz.1 
ENSMUST00000313569.1 ENSMUSG00000132700 ENSMUST00000313569.1 ENSMUSG00000132700 (from geneSymbol) uc335fms.1 uc335fms.1 
ENSMUST00000313571.1 ENSMUSG00000132701 ENSMUST00000313571.1 ENSMUSG00000132701 (from geneSymbol) uc335fmu.1 uc335fmu.1 
ENSMUST00000313579.1 ENSMUSG00000132702 ENSMUST00000313579.1 ENSMUSG00000132702 (from geneSymbol) uc335fnc.1 uc335fnc.1 
ENSMUST00000313580.1 ENSMUSG00000132703 ENSMUST00000313580.1 ENSMUSG00000132703 (from geneSymbol) uc335fnd.1 uc335fnd.1 
ENSMUST00000313582.1 ENSMUSG00000132704 ENSMUST00000313582.1 ENSMUSG00000132704 (from geneSymbol) uc335fnf.1 uc335fnf.1 
ENSMUST00000313585.1 Gm56601 ENSMUST00000313585.1 Gm56601 (from geneSymbol) uc335fni.1 uc335fni.1 
ENSMUST00000313587.1 ENSMUSG00000132705 ENSMUST00000313587.1 ENSMUSG00000132705 (from geneSymbol) AK140967 uc335fnk.1 uc335fnk.1 
ENSMUST00000313591.1 ENSMUSG00000132706 ENSMUST00000313591.1 ENSMUSG00000132706 (from geneSymbol) uc335fno.1 uc335fno.1 
ENSMUST00000313593.1 ENSMUSG00000132707 ENSMUST00000313593.1 ENSMUSG00000132707 (from geneSymbol) uc335fnq.1 uc335fnq.1 
ENSMUST00000313597.1 ENSMUSG00000132708 ENSMUST00000313597.1 ENSMUSG00000132708 (from geneSymbol) uc335fnu.1 uc335fnu.1 
ENSMUST00000313598.1 ENSMUSG00000132709 ENSMUST00000313598.1 ENSMUSG00000132709 (from geneSymbol) uc335fnv.1 uc335fnv.1 
ENSMUST00000313604.1 Gm30075 ENSMUST00000313604.1 Gm30075 (from geneSymbol) AK076338 uc335foa.1 uc335foa.1 
ENSMUST00000313609.1 ENSMUSG00000132710 ENSMUST00000313609.1 ENSMUSG00000132710 (from geneSymbol) uc335fof.1 uc335fof.1 
ENSMUST00000313615.1 Gm42196 ENSMUST00000313615.1 Gm42196 (from geneSymbol) uc335fol.1 uc335fol.1 
ENSMUST00000313622.1 ENSMUSG00000132711 ENSMUST00000313622.1 ENSMUSG00000132711 (from geneSymbol) uc335fos.1 uc335fos.1 
ENSMUST00000313640.1 Gm32004 ENSMUST00000313640.1 Gm32004 (from geneSymbol) AK138842 uc335fpk.1 uc335fpk.1 
ENSMUST00000313645.1 ENSMUSG00000132712 ENSMUST00000313645.1 ENSMUSG00000132712 (from geneSymbol) uc335fpp.1 uc335fpp.1 
ENSMUST00000313646.1 ENSMUSG00000132713 ENSMUST00000313646.1 ENSMUSG00000132713 (from geneSymbol) uc335fpq.1 uc335fpq.1 
ENSMUST00000313650.1 Gm46606 ENSMUST00000313650.1 Gm46606 (from geneSymbol) uc335fpu.1 uc335fpu.1 
ENSMUST00000313655.1 ENSMUSG00000132714 ENSMUST00000313655.1 ENSMUSG00000132714 (from geneSymbol) uc335fpz.1 uc335fpz.1 
ENSMUST00000313660.1 ENSMUSG00000132715 ENSMUST00000313660.1 ENSMUSG00000132715 (from geneSymbol) uc335fqe.1 uc335fqe.1 
ENSMUST00000313668.1 ENSMUSG00000132716 ENSMUST00000313668.1 ENSMUSG00000132716 (from geneSymbol) uc335fqm.1 uc335fqm.1 
ENSMUST00000313670.1 ENSMUSG00000132717 ENSMUST00000313670.1 ENSMUSG00000132717 (from geneSymbol) uc335fqo.1 uc335fqo.1 
ENSMUST00000313674.1 ENSMUSG00000132718 ENSMUST00000313674.1 ENSMUSG00000132718 (from geneSymbol) uc335fqs.1 uc335fqs.1 
ENSMUST00000313684.1 AA387200 ENSMUST00000313684.1 AA387200 (from geneSymbol) uc335frc.1 uc335frc.1 
ENSMUST00000313691.1 ENSMUSG00000132719 ENSMUST00000313691.1 ENSMUSG00000132719 (from geneSymbol) uc335frj.1 uc335frj.1 
ENSMUST00000313695.1 ENSMUSG00000132721 ENSMUST00000313695.1 ENSMUSG00000132721 (from geneSymbol) uc335frm.1 uc335frm.1 
ENSMUST00000313696.1 ENSMUSG00000132722 ENSMUST00000313696.1 ENSMUSG00000132722 (from geneSymbol) uc335frn.1 uc335frn.1 
ENSMUST00000313701.1 ENSMUSG00000132723 ENSMUST00000313701.1 ENSMUSG00000132723 (from geneSymbol) uc335frs.1 uc335frs.1 
ENSMUST00000313706.1 Gm35576 ENSMUST00000313706.1 Gm35576 (from geneSymbol) uc335frx.1 uc335frx.1 
ENSMUST00000313715.1 Gm26796 ENSMUST00000313715.1 Gm26796 (from geneSymbol) uc335fsg.1 uc335fsg.1 
ENSMUST00000313717.1 ENSMUSG00000132724 ENSMUST00000313717.1 ENSMUSG00000132724 (from geneSymbol) uc335fsi.1 uc335fsi.1 
ENSMUST00000313720.1 ENSMUSG00000132725 ENSMUST00000313720.1 ENSMUSG00000132725 (from geneSymbol) uc335fsl.1 uc335fsl.1 
ENSMUST00000313723.1 ENSMUSG00000132726 ENSMUST00000313723.1 ENSMUSG00000132726 (from geneSymbol) uc335fso.1 uc335fso.1 
ENSMUST00000313731.1 C330020E22Rik ENSMUST00000313731.1 C330020E22Rik (from geneSymbol) AK079836 uc335fsw.1 uc335fsw.1 
ENSMUST00000313740.1 ENSMUSG00000132727 ENSMUST00000313740.1 ENSMUSG00000132727 (from geneSymbol) uc335ftf.1 uc335ftf.1 
ENSMUST00000313741.1 ENSMUSG00000132728 ENSMUST00000313741.1 ENSMUSG00000132728 (from geneSymbol) uc335ftg.1 uc335ftg.1 
ENSMUST00000313745.1 ENSMUSG00000132729 ENSMUST00000313745.1 ENSMUSG00000132729 (from geneSymbol) uc335ftk.1 uc335ftk.1 
ENSMUST00000313749.1 ENSMUSG00000132730 ENSMUST00000313749.1 ENSMUSG00000132730 (from geneSymbol) uc335fto.1 uc335fto.1 
ENSMUST00000313750.1 ENSMUSG00000132731 ENSMUST00000313750.1 ENSMUSG00000132731 (from geneSymbol) LF193055 uc335ftp.1 uc335ftp.1 
ENSMUST00000313751.1 ENSMUSG00000132732 ENSMUST00000313751.1 ENSMUSG00000132732 (from geneSymbol) uc335ftq.1 uc335ftq.1 
ENSMUST00000313754.1 ENSMUSG00000132733 ENSMUST00000313754.1 ENSMUSG00000132733 (from geneSymbol) uc335ftt.1 uc335ftt.1 
ENSMUST00000313757.1 ENSMUSG00000132734 ENSMUST00000313757.1 ENSMUSG00000132734 (from geneSymbol) uc335ftw.1 uc335ftw.1 
ENSMUST00000313766.1 ENSMUSG00000132735 ENSMUST00000313766.1 ENSMUSG00000132735 (from geneSymbol) uc335fue.1 uc335fue.1 
ENSMUST00000313767.1 Gm49066 ENSMUST00000313767.1 Gm49066 (from geneSymbol) uc335fuf.1 uc335fuf.1 
ENSMUST00000313771.1 Gm13442 ENSMUST00000313771.1 Gm13442 (from geneSymbol) uc335fui.1 uc335fui.1 
ENSMUST00000313772.1 ENSMUSG00000132737 ENSMUST00000313772.1 ENSMUSG00000132737 (from geneSymbol) uc335fuj.1 uc335fuj.1 
ENSMUST00000313777.1 ENSMUSG00000132738 ENSMUST00000313777.1 ENSMUSG00000132738 (from geneSymbol) uc335fuo.1 uc335fuo.1 
ENSMUST00000313778.1 ENSMUSG00000132739 ENSMUST00000313778.1 ENSMUSG00000132739 (from geneSymbol) uc335fup.1 uc335fup.1 
ENSMUST00000313779.1 ENSMUSG00000132740 ENSMUST00000313779.1 ENSMUSG00000132740 (from geneSymbol) uc335fuq.1 uc335fuq.1 
ENSMUST00000313780.1 ENSMUSG00000132741 ENSMUST00000313780.1 ENSMUSG00000132741 (from geneSymbol) uc335fur.1 uc335fur.1 
ENSMUST00000313786.1 ENSMUSG00000132743 ENSMUST00000313786.1 ENSMUSG00000132743 (from geneSymbol) BC145074 uc335fuw.1 uc335fuw.1 
ENSMUST00000313787.1 ENSMUSG00000132744 ENSMUST00000313787.1 ENSMUSG00000132744 (from geneSymbol) uc335fux.1 uc335fux.1 
ENSMUST00000313790.1 ENSMUSG00000132745 ENSMUST00000313790.1 ENSMUSG00000132745 (from geneSymbol) uc335fva.1 uc335fva.1 
ENSMUST00000313811.1 4930425P05Rik ENSMUST00000313811.1 4930425P05Rik (from geneSymbol) uc335fvv.1 uc335fvv.1 
ENSMUST00000313819.1 ENSMUSG00000132746 ENSMUST00000313819.1 ENSMUSG00000132746 (from geneSymbol) uc335fwd.1 uc335fwd.1 
ENSMUST00000313822.1 ENSMUSG00000132747 ENSMUST00000313822.1 ENSMUSG00000132747 (from geneSymbol) uc335fwg.1 uc335fwg.1 
ENSMUST00000313827.1 ENSMUSG00000132748 ENSMUST00000313827.1 ENSMUSG00000132748 (from geneSymbol) uc335fwl.1 uc335fwl.1 
ENSMUST00000313834.1 ENSMUSG00000132749 ENSMUST00000313834.1 ENSMUSG00000132749 (from geneSymbol) uc335fws.1 uc335fws.1 
ENSMUST00000313837.1 ENSMUSG00000132750 ENSMUST00000313837.1 ENSMUSG00000132750 (from geneSymbol) uc335fwv.1 uc335fwv.1 
ENSMUST00000313842.1 ENSMUSG00000132751 ENSMUST00000313842.1 ENSMUSG00000132751 (from geneSymbol) uc335fxa.1 uc335fxa.1 
ENSMUST00000313847.1 ENSMUSG00000132752 ENSMUST00000313847.1 ENSMUSG00000132752 (from geneSymbol) uc335fxf.1 uc335fxf.1 
ENSMUST00000313848.1 ENSMUSG00000132753 ENSMUST00000313848.1 ENSMUSG00000132753 (from geneSymbol) uc335fxg.1 uc335fxg.1 
ENSMUST00000313849.1 ENSMUSG00000132754 ENSMUST00000313849.1 ENSMUSG00000132754 (from geneSymbol) uc335fxh.1 uc335fxh.1 
ENSMUST00000313850.1 ENSMUSG00000132755 ENSMUST00000313850.1 ENSMUSG00000132755 (from geneSymbol) uc335fxi.1 uc335fxi.1 
ENSMUST00000313852.1 ENSMUSG00000132756 ENSMUST00000313852.1 ENSMUSG00000132756 (from geneSymbol) uc335fxk.1 uc335fxk.1 
ENSMUST00000313853.1 ENSMUSG00000132757 ENSMUST00000313853.1 ENSMUSG00000132757 (from geneSymbol) uc335fxl.1 uc335fxl.1 
ENSMUST00000313898.1 1700125G22Rik ENSMUST00000313898.1 1700125G22Rik (from geneSymbol) AK007279 uc335fzd.1 uc335fzd.1 
ENSMUST00000313913.1 ENSMUSG00000132758 ENSMUST00000313913.1 ENSMUSG00000132758 (from geneSymbol) uc335fzs.1 uc335fzs.1 
ENSMUST00000313914.1 ENSMUSG00000132759 ENSMUST00000313914.1 ENSMUSG00000132759 (from geneSymbol) uc335fzt.1 uc335fzt.1 
ENSMUST00000313915.1 ENSMUSG00000132760 ENSMUST00000313915.1 ENSMUSG00000132760 (from geneSymbol) uc335fzu.1 uc335fzu.1 
ENSMUST00000313920.1 ENSMUSG00000132761 ENSMUST00000313920.1 ENSMUSG00000132761 (from geneSymbol) uc335fzz.1 uc335fzz.1 
ENSMUST00000313921.1 Gm5091 ENSMUST00000313921.1 Gm5091 (from geneSymbol) AK082876 uc335gaa.1 uc335gaa.1 
ENSMUST00000313935.1 ENSMUSG00000132762 ENSMUST00000313935.1 ENSMUSG00000132762 (from geneSymbol) uc335gao.1 uc335gao.1 
ENSMUST00000313936.1 ENSMUSG00000132763 ENSMUST00000313936.1 ENSMUSG00000132763 (from geneSymbol) uc335gap.1 uc335gap.1 
ENSMUST00000313937.1 ENSMUSG00000132764 ENSMUST00000313937.1 ENSMUSG00000132764 (from geneSymbol) uc335gaq.1 uc335gaq.1 
ENSMUST00000313938.1 ENSMUSG00000132765 ENSMUST00000313938.1 ENSMUSG00000132765 (from geneSymbol) uc335gar.1 uc335gar.1 
ENSMUST00000313940.1 ENSMUSG00000132766 ENSMUST00000313940.1 ENSMUSG00000132766 (from geneSymbol) uc335gat.1 uc335gat.1 
ENSMUST00000313944.1 ENSMUSG00000132767 ENSMUST00000313944.1 ENSMUSG00000132767 (from geneSymbol) uc335gax.1 uc335gax.1 
ENSMUST00000313970.1 1700001G01Rik ENSMUST00000313970.1 1700001G01Rik (from geneSymbol) AK133007 uc335gbx.1 uc335gbx.1 
ENSMUST00000313994.1 ENSMUSG00000132768 ENSMUST00000313994.1 ENSMUSG00000132768 (from geneSymbol) uc335gcv.1 uc335gcv.1 
ENSMUST00000313996.1 ENSMUSG00000132769 ENSMUST00000313996.1 ENSMUSG00000132769 (from geneSymbol) uc335gcx.1 uc335gcx.1 
ENSMUST00000313997.1 ENSMUSG00000132770 ENSMUST00000313997.1 ENSMUSG00000132770 (from geneSymbol) uc335gcy.1 uc335gcy.1 
ENSMUST00000313998.1 ENSMUSG00000132771 ENSMUST00000313998.1 ENSMUSG00000132771 (from geneSymbol) uc335gcz.1 uc335gcz.1 
ENSMUST00000314000.1 Gm29345 ENSMUST00000314000.1 Gm29345 (from geneSymbol) uc335gdb.1 uc335gdb.1 
ENSMUST00000314002.1 ENSMUSG00000132772 ENSMUST00000314002.1 ENSMUSG00000132772 (from geneSymbol) uc335gdd.1 uc335gdd.1 
ENSMUST00000314003.1 ENSMUSG00000132773 ENSMUST00000314003.1 ENSMUSG00000132773 (from geneSymbol) uc335gde.1 uc335gde.1 
ENSMUST00000314008.1 ENSMUSG00000132774 ENSMUST00000314008.1 ENSMUSG00000132774 (from geneSymbol) DQ726815 uc335gdj.1 uc335gdj.1 
ENSMUST00000314009.1 ENSMUSG00000132775 ENSMUST00000314009.1 ENSMUSG00000132775 (from geneSymbol) uc335gdk.1 uc335gdk.1 
ENSMUST00000314020.1 ENSMUSG00000132776 ENSMUST00000314020.1 ENSMUSG00000132776 (from geneSymbol) uc335gdv.1 uc335gdv.1 
ENSMUST00000314021.1 ENSMUSG00000132777 ENSMUST00000314021.1 ENSMUSG00000132777 (from geneSymbol) uc335gdw.1 uc335gdw.1 
ENSMUST00000314022.1 ENSMUSG00000132778 ENSMUST00000314022.1 ENSMUSG00000132778 (from geneSymbol) uc335gdx.1 uc335gdx.1 
ENSMUST00000314023.1 ENSMUSG00000132779 ENSMUST00000314023.1 ENSMUSG00000132779 (from geneSymbol) uc335gdy.1 uc335gdy.1 
ENSMUST00000314025.1 ENSMUSG00000132780 ENSMUST00000314025.1 ENSMUSG00000132780 (from geneSymbol) uc335gea.1 uc335gea.1 
ENSMUST00000314026.1 ENSMUSG00000132781 ENSMUST00000314026.1 ENSMUSG00000132781 (from geneSymbol) uc335geb.1 uc335geb.1 
ENSMUST00000314030.1 ENSMUSG00000132782 ENSMUST00000314030.1 ENSMUSG00000132782 (from geneSymbol) uc335gef.1 uc335gef.1 
ENSMUST00000314032.1 ENSMUSG00000132783 ENSMUST00000314032.1 ENSMUSG00000132783 (from geneSymbol) uc335geh.1 uc335geh.1 
ENSMUST00000314033.1 ENSMUSG00000132784 ENSMUST00000314033.1 ENSMUSG00000132784 (from geneSymbol) uc335gei.1 uc335gei.1 
ENSMUST00000314039.1 ENSMUSG00000132785 ENSMUST00000314039.1 ENSMUSG00000132785 (from geneSymbol) uc335gen.1 uc335gen.1 
ENSMUST00000314040.1 ENSMUSG00000132786 ENSMUST00000314040.1 ENSMUSG00000132786 (from geneSymbol) uc335geo.1 uc335geo.1 
ENSMUST00000314060.1 ENSMUSG00000132787 ENSMUST00000314060.1 ENSMUSG00000132787 (from geneSymbol) uc335gfi.1 uc335gfi.1 
ENSMUST00000314064.1 ENSMUSG00000132788 ENSMUST00000314064.1 ENSMUSG00000132788 (from geneSymbol) uc335gfm.1 uc335gfm.1 
ENSMUST00000314065.1 ENSMUSG00000132789 ENSMUST00000314065.1 ENSMUSG00000132789 (from geneSymbol) uc335gfn.1 uc335gfn.1 
ENSMUST00000314074.1 ENSMUSG00000132790 ENSMUST00000314074.1 ENSMUSG00000132790 (from geneSymbol) uc335gfw.1 uc335gfw.1 
ENSMUST00000314077.1 ENSMUSG00000132791 ENSMUST00000314077.1 ENSMUSG00000132791 (from geneSymbol) uc335gfz.1 uc335gfz.1 
ENSMUST00000314078.1 ENSMUSG00000132792 ENSMUST00000314078.1 ENSMUSG00000132792 (from geneSymbol) uc335gga.1 uc335gga.1 
ENSMUST00000314079.1 ENSMUSG00000132793 ENSMUST00000314079.1 ENSMUSG00000132793 (from geneSymbol) uc335ggb.1 uc335ggb.1 
ENSMUST00000314085.1 ENSMUSG00000132794 ENSMUST00000314085.1 ENSMUSG00000132794 (from geneSymbol) uc335ggh.1 uc335ggh.1 
ENSMUST00000314086.1 ENSMUSG00000132795 ENSMUST00000314086.1 ENSMUSG00000132795 (from geneSymbol) uc335ggi.1 uc335ggi.1 
ENSMUST00000314087.1 ENSMUSG00000132796 ENSMUST00000314087.1 ENSMUSG00000132796 (from geneSymbol) uc335ggj.1 uc335ggj.1 
ENSMUST00000314089.1 ENSMUSG00000132797 ENSMUST00000314089.1 ENSMUSG00000132797 (from geneSymbol) uc335ggl.1 uc335ggl.1 
ENSMUST00000314092.1 ENSMUSG00000132798 ENSMUST00000314092.1 ENSMUSG00000132798 (from geneSymbol) uc335ggn.1 uc335ggn.1 
ENSMUST00000314093.1 ENSMUSG00000132799 ENSMUST00000314093.1 ENSMUSG00000132799 (from geneSymbol) uc335ggo.1 uc335ggo.1 
ENSMUST00000314095.1 ENSMUSG00000132800 ENSMUST00000314095.1 ENSMUSG00000132800 (from geneSymbol) uc335ggq.1 uc335ggq.1 
ENSMUST00000314117.1 ENSMUSG00000132801 ENSMUST00000314117.1 ENSMUSG00000132801 (from geneSymbol) uc335ghm.1 uc335ghm.1 
ENSMUST00000314118.1 ENSMUSG00000132802 ENSMUST00000314118.1 ENSMUSG00000132802 (from geneSymbol) uc335ghn.1 uc335ghn.1 
ENSMUST00000314131.1 ENSMUSG00000132803 ENSMUST00000314131.1 ENSMUSG00000132803 (from geneSymbol) uc335gia.1 uc335gia.1 
ENSMUST00000314134.1 Gm36634 ENSMUST00000314134.1 Gm36634 (from geneSymbol) uc335gid.1 uc335gid.1 
ENSMUST00000314142.1 ENSMUSG00000132804 ENSMUST00000314142.1 ENSMUSG00000132804 (from geneSymbol) uc335gil.1 uc335gil.1 
ENSMUST00000314143.1 ENSMUSG00000132805 ENSMUST00000314143.1 ENSMUSG00000132805 (from geneSymbol) uc335gim.1 uc335gim.1 
ENSMUST00000314145.1 ENSMUSG00000132806 ENSMUST00000314145.1 ENSMUSG00000132806 (from geneSymbol) uc335gio.1 uc335gio.1 
ENSMUST00000314146.1 ENSMUSG00000132807 ENSMUST00000314146.1 ENSMUSG00000132807 (from geneSymbol) uc335gip.1 uc335gip.1 
ENSMUST00000314147.1 ENSMUSG00000132808 ENSMUST00000314147.1 ENSMUSG00000132808 (from geneSymbol) uc335giq.1 uc335giq.1 
ENSMUST00000314149.1 Gnasas1 ENSMUST00000314149.1 Gnasas1 (from geneSymbol) AF319945 uc335gis.1 uc335gis.1 
ENSMUST00000314164.1 ENSMUSG00000132809 ENSMUST00000314164.1 ENSMUSG00000132809 (from geneSymbol) uc335gjh.1 uc335gjh.1 
ENSMUST00000314165.1 ENSMUSG00000132810 ENSMUST00000314165.1 ENSMUSG00000132810 (from geneSymbol) uc335gji.1 uc335gji.1 
ENSMUST00000314167.1 ENSMUSG00000132811 ENSMUST00000314167.1 ENSMUSG00000132811 (from geneSymbol) uc335gjk.1 uc335gjk.1 
ENSMUST00000314168.1 ENSMUSG00000132812 ENSMUST00000314168.1 ENSMUSG00000132812 (from geneSymbol) uc335gjl.1 uc335gjl.1 
ENSMUST00000314172.1 ENSMUSG00000132813 ENSMUST00000314172.1 ENSMUSG00000132813 (from geneSymbol) uc335gjp.1 uc335gjp.1 
ENSMUST00000314174.1 ENSMUSG00000132814 ENSMUST00000314174.1 ENSMUSG00000132814 (from geneSymbol) uc335gjr.1 uc335gjr.1 
ENSMUST00000314176.1 ENSMUSG00000132815 ENSMUST00000314176.1 ENSMUSG00000132815 (from geneSymbol) uc335gjt.1 uc335gjt.1 
ENSMUST00000314185.1 ENSMUSG00000132816 ENSMUST00000314185.1 ENSMUSG00000132816 (from geneSymbol) uc335gkc.1 uc335gkc.1 
ENSMUST00000314186.1 ENSMUSG00000132817 ENSMUST00000314186.1 ENSMUSG00000132817 (from geneSymbol) uc335gkd.1 uc335gkd.1 
ENSMUST00000314187.1 ENSMUSG00000132818 ENSMUST00000314187.1 ENSMUSG00000132818 (from geneSymbol) uc335gke.1 uc335gke.1 
ENSMUST00000314188.1 ENSMUSG00000132819 ENSMUST00000314188.1 ENSMUSG00000132819 (from geneSymbol) uc335gkf.1 uc335gkf.1 
ENSMUST00000314190.1 ENSMUSG00000132820 ENSMUST00000314190.1 ENSMUSG00000132820 (from geneSymbol) uc335gkh.1 uc335gkh.1 
ENSMUST00000314191.1 ENSMUSG00000132821 ENSMUST00000314191.1 ENSMUSG00000132821 (from geneSymbol) uc335gki.1 uc335gki.1 
ENSMUST00000314192.1 ENSMUSG00000132822 ENSMUST00000314192.1 ENSMUSG00000132822 (from geneSymbol) uc335gkj.1 uc335gkj.1 
ENSMUST00000314193.1 ENSMUSG00000132823 ENSMUST00000314193.1 ENSMUSG00000132823 (from geneSymbol) uc335gkk.1 uc335gkk.1 
ENSMUST00000314195.1 Gm34307 ENSMUST00000314195.1 Gm34307 (from geneSymbol) uc335gkm.1 uc335gkm.1 
ENSMUST00000314197.1 ENSMUSG00000132824 ENSMUST00000314197.1 ENSMUSG00000132824 (from geneSymbol) uc335gko.1 uc335gko.1 
ENSMUST00000314199.1 ENSMUSG00000132825 ENSMUST00000314199.1 ENSMUSG00000132825 (from geneSymbol) uc335gkq.1 uc335gkq.1 
ENSMUST00000314201.1 ENSMUSG00000132827 ENSMUST00000314201.1 ENSMUSG00000132827 (from geneSymbol) uc335gkr.1 uc335gkr.1 
ENSMUST00000314202.1 ENSMUSG00000132828 ENSMUST00000314202.1 ENSMUSG00000132828 (from geneSymbol) uc335gks.1 uc335gks.1 
ENSMUST00000314203.1 ENSMUSG00000132829 ENSMUST00000314203.1 ENSMUSG00000132829 (from geneSymbol) uc335gkt.1 uc335gkt.1 
ENSMUST00000314210.1 ENSMUSG00000132830 ENSMUST00000314210.1 ENSMUSG00000132830 (from geneSymbol) uc335gla.1 uc335gla.1 
ENSMUST00000314212.1 ENSMUSG00000132831 ENSMUST00000314212.1 ENSMUSG00000132831 (from geneSymbol) uc335glc.1 uc335glc.1 
ENSMUST00000314213.1 ENSMUSG00000132832 ENSMUST00000314213.1 ENSMUSG00000132832 (from geneSymbol) uc335gld.1 uc335gld.1 
ENSMUST00000314227.1 4930442G10Rik ENSMUST00000314227.1 4930442G10Rik (from geneSymbol) AK015361 uc335glr.1 uc335glr.1 
ENSMUST00000314230.1 ENSMUSG00000132833 ENSMUST00000314230.1 ENSMUSG00000132833 (from geneSymbol) uc335glu.1 uc335glu.1 
ENSMUST00000314231.1 ENSMUSG00000132834 ENSMUST00000314231.1 ENSMUSG00000132834 (from geneSymbol) uc335glv.1 uc335glv.1 
ENSMUST00000314232.1 ENSMUSG00000132835 ENSMUST00000314232.1 ENSMUSG00000132835 (from geneSymbol) uc335glw.1 uc335glw.1 
ENSMUST00000314237.1 ENSMUSG00000132836 ENSMUST00000314237.1 ENSMUSG00000132836 (from geneSymbol) uc335gmb.1 uc335gmb.1 
ENSMUST00000314248.1 ENSMUSG00000132837 ENSMUST00000314248.1 ENSMUSG00000132837 (from geneSymbol) uc335gmm.1 uc335gmm.1 
ENSMUST00000314256.1 ENSMUSG00000132838 ENSMUST00000314256.1 ENSMUSG00000132838 (from geneSymbol) uc335gmu.1 uc335gmu.1 
ENSMUST00000314258.1 ENSMUSG00000132839 ENSMUST00000314258.1 ENSMUSG00000132839 (from geneSymbol) uc335gmw.1 uc335gmw.1 
ENSMUST00000314259.1 ENSMUSG00000132840 ENSMUST00000314259.1 ENSMUSG00000132840 (from geneSymbol) uc335gmx.1 uc335gmx.1 
ENSMUST00000314260.1 ENSMUSG00000132841 ENSMUST00000314260.1 ENSMUSG00000132841 (from geneSymbol) uc335gmy.1 uc335gmy.1 
ENSMUST00000314294.1 ENSMUSG00000132842 ENSMUST00000314294.1 ENSMUSG00000132842 (from geneSymbol) uc335gof.1 uc335gof.1 
ENSMUST00000314297.1 ENSMUSG00000132843 ENSMUST00000314297.1 ENSMUSG00000132843 (from geneSymbol) uc335goi.1 uc335goi.1 
ENSMUST00000314308.1 2700069I18Rik ENSMUST00000314308.1 2700069I18Rik (from geneSymbol) AK012506 uc335got.1 uc335got.1 
ENSMUST00000314311.1 ENSMUSG00000132844 ENSMUST00000314311.1 ENSMUSG00000132844 (from geneSymbol) uc335gow.1 uc335gow.1 
ENSMUST00000314312.1 ENSMUSG00000132845 ENSMUST00000314312.1 ENSMUSG00000132845 (from geneSymbol) uc335gox.1 uc335gox.1 
ENSMUST00000314314.1 ENSMUSG00000132846 ENSMUST00000314314.1 ENSMUSG00000132846 (from geneSymbol) AK138371 uc335goz.1 uc335goz.1 
ENSMUST00000314315.1 ENSMUSG00000132847 ENSMUST00000314315.1 ENSMUSG00000132847 (from geneSymbol) uc335gpa.1 uc335gpa.1 
ENSMUST00000314334.1 ENSMUSG00000132848 ENSMUST00000314334.1 ENSMUSG00000132848 (from geneSymbol) uc335gpt.1 uc335gpt.1 
ENSMUST00000314351.1 ENSMUSG00000132849 ENSMUST00000314351.1 ENSMUSG00000132849 (from geneSymbol) uc335gqk.1 uc335gqk.1 
ENSMUST00000314353.1 Tmem132cos ENSMUST00000314353.1 Tmem132cos (from geneSymbol) AK007002 uc335gqm.1 uc335gqm.1 
ENSMUST00000314367.1 ENSMUSG00000132850 ENSMUST00000314367.1 ENSMUSG00000132850 (from geneSymbol) uc335gra.1 uc335gra.1 
ENSMUST00000314370.1 ENSMUSG00000132851 ENSMUST00000314370.1 ENSMUSG00000132851 (from geneSymbol) uc335grd.1 uc335grd.1 
ENSMUST00000314373.1 4930529L06Rik ENSMUST00000314373.1 4930529L06Rik (from geneSymbol) AK019711 uc335grf.1 uc335grf.1 
ENSMUST00000314377.1 Gm31614 ENSMUST00000314377.1 Gm31614 (from geneSymbol) uc335grj.1 uc335grj.1 
ENSMUST00000314389.1 4930599A14Rik ENSMUST00000314389.1 4930599A14Rik (from geneSymbol) AK016413 uc335grv.1 uc335grv.1 
ENSMUST00000314392.1 ENSMUSG00000132854 ENSMUST00000314392.1 ENSMUSG00000132854 (from geneSymbol) uc335gry.1 uc335gry.1 
ENSMUST00000314393.1 ENSMUSG00000132855 ENSMUST00000314393.1 ENSMUSG00000132855 (from geneSymbol) AK132862 uc335grz.1 uc335grz.1 
ENSMUST00000314409.1 ENSMUSG00000132856 ENSMUST00000314409.1 ENSMUSG00000132856 (from geneSymbol) uc335gsp.1 uc335gsp.1 
ENSMUST00000314415.1 ENSMUSG00000132858 ENSMUST00000314415.1 ENSMUSG00000132858 (from geneSymbol) uc335gsu.1 uc335gsu.1 
ENSMUST00000314417.1 ENSMUSG00000132859 ENSMUST00000314417.1 ENSMUSG00000132859 (from geneSymbol) uc335gsw.1 uc335gsw.1 
ENSMUST00000314418.1 Gm12406 ENSMUST00000314418.1 Gm12406 (from geneSymbol) uc335gsx.1 uc335gsx.1 
ENSMUST00000314425.1 Gm28556 ENSMUST00000314425.1 Gm28556 (from geneSymbol) AK040222 uc335gte.1 uc335gte.1 
ENSMUST00000314426.1 ENSMUSG00000132860 ENSMUST00000314426.1 ENSMUSG00000132860 (from geneSymbol) uc335gtf.1 uc335gtf.1 
ENSMUST00000314427.1 ENSMUSG00000132861 ENSMUST00000314427.1 ENSMUSG00000132861 (from geneSymbol) uc335gtg.1 uc335gtg.1 
ENSMUST00000314429.1 ENSMUSG00000132862 ENSMUST00000314429.1 ENSMUSG00000132862 (from geneSymbol) uc335gti.1 uc335gti.1 
ENSMUST00000314430.1 ENSMUSG00000132863 ENSMUST00000314430.1 ENSMUSG00000132863 (from geneSymbol) uc335gtj.1 uc335gtj.1 
ENSMUST00000314431.1 ENSMUSG00000132864 ENSMUST00000314431.1 ENSMUSG00000132864 (from geneSymbol) AK035404 uc335gtk.1 uc335gtk.1 
ENSMUST00000314434.1 ENSMUSG00000132865 ENSMUST00000314434.1 ENSMUSG00000132865 (from geneSymbol) uc335gtn.1 uc335gtn.1 
ENSMUST00000314436.1 Gm47515 ENSMUST00000314436.1 Gm47515 (from geneSymbol) uc335gtp.1 uc335gtp.1 
ENSMUST00000314441.1 Teshl ENSMUST00000314441.1 Teshl (from geneSymbol) uc335gtu.1 uc335gtu.1 
ENSMUST00000314524.1 ENSMUSG00000132866 ENSMUST00000314524.1 ENSMUSG00000132866 (from geneSymbol) uc335gwz.1 uc335gwz.1 
ENSMUST00000314525.1 ENSMUSG00000132867 ENSMUST00000314525.1 ENSMUSG00000132867 (from geneSymbol) uc335gxa.1 uc335gxa.1 
ENSMUST00000314526.1 ENSMUSG00000132868 ENSMUST00000314526.1 ENSMUSG00000132868 (from geneSymbol) uc335gxb.1 uc335gxb.1 
ENSMUST00000314528.1 Gm36069 ENSMUST00000314528.1 Gm36069 (from geneSymbol) uc335gxd.1 uc335gxd.1 
ENSMUST00000314535.1 ENSMUSG00000132870 ENSMUST00000314535.1 ENSMUSG00000132870 (from geneSymbol) uc335gxk.1 uc335gxk.1 
ENSMUST00000314566.1 ENSMUSG00000132871 ENSMUST00000314566.1 ENSMUSG00000132871 (from geneSymbol) uc335gyp.1 uc335gyp.1 
ENSMUST00000314568.1 ENSMUSG00000132872 ENSMUST00000314568.1 ENSMUSG00000132872 (from geneSymbol) BC099537 uc335gyr.1 uc335gyr.1 
ENSMUST00000314569.1 ENSMUSG00000132873 ENSMUST00000314569.1 ENSMUSG00000132873 (from geneSymbol) uc335gys.1 uc335gys.1 
ENSMUST00000314571.1 Gm35248 ENSMUST00000314571.1 Gm35248 (from geneSymbol) uc335gyu.1 uc335gyu.1 
ENSMUST00000314579.1 ENSMUSG00000132874 ENSMUST00000314579.1 ENSMUSG00000132874 (from geneSymbol) uc335gzc.1 uc335gzc.1 
ENSMUST00000314581.1 4930447M23Rik ENSMUST00000314581.1 4930447M23Rik (from geneSymbol) AK076779 uc335gze.1 uc335gze.1 
ENSMUST00000314632.1 ENSMUSG00000132875 ENSMUST00000314632.1 ENSMUSG00000132875 (from geneSymbol) uc335hbd.1 uc335hbd.1 
ENSMUST00000314639.1 ENSMUSG00000132876 ENSMUST00000314639.1 ENSMUSG00000132876 (from geneSymbol) uc335hbk.1 uc335hbk.1 
ENSMUST00000314640.1 ENSMUSG00000132877 ENSMUST00000314640.1 ENSMUSG00000132877 (from geneSymbol) uc335hbl.1 uc335hbl.1 
ENSMUST00000314642.1 ENSMUSG00000132878 ENSMUST00000314642.1 ENSMUSG00000132878 (from geneSymbol) uc335hbn.1 uc335hbn.1 
ENSMUST00000314644.1 ENSMUSG00000132879 ENSMUST00000314644.1 ENSMUSG00000132879 (from geneSymbol) uc335hbp.1 uc335hbp.1 
ENSMUST00000314648.1 Gm57305 ENSMUST00000314648.1 Gm57305 (from geneSymbol) uc335hbt.1 uc335hbt.1 
ENSMUST00000314655.1 ENSMUSG00000132880 ENSMUST00000314655.1 ENSMUSG00000132880 (from geneSymbol) uc335hca.1 uc335hca.1 
ENSMUST00000314657.1 ENSMUSG00000132881 ENSMUST00000314657.1 ENSMUSG00000132881 (from geneSymbol) uc335hcc.1 uc335hcc.1 
ENSMUST00000314661.1 ENSMUSG00000132882 ENSMUST00000314661.1 ENSMUSG00000132882 (from geneSymbol) uc335hcg.1 uc335hcg.1 
ENSMUST00000314682.1 ENSMUSG00000132883 ENSMUST00000314682.1 ENSMUSG00000132883 (from geneSymbol) uc335hdb.1 uc335hdb.1 
ENSMUST00000314683.1 ENSMUSG00000132884 ENSMUST00000314683.1 ENSMUSG00000132884 (from geneSymbol) uc335hdc.1 uc335hdc.1 
ENSMUST00000314684.1 ENSMUSG00000132885 ENSMUST00000314684.1 ENSMUSG00000132885 (from geneSymbol) uc335hdd.1 uc335hdd.1 
ENSMUST00000314687.1 ENSMUSG00000132886 ENSMUST00000314687.1 ENSMUSG00000132886 (from geneSymbol) uc335hdg.1 uc335hdg.1 
ENSMUST00000314697.1 Gm10732 ENSMUST00000314697.1 Gm10732 (from geneSymbol) AK143952 uc335hdq.1 uc335hdq.1 
ENSMUST00000314708.1 ENSMUSG00000132887 ENSMUST00000314708.1 predicted gene, 30189, transcript variant 2 (from RefSeq NR_166448.1) NR_166448 uc335heb.1 uc335heb.1 
ENSMUST00000314711.1 ENSMUSG00000132888 ENSMUST00000314711.1 ENSMUSG00000132888 (from geneSymbol) uc335hee.1 uc335hee.1 
ENSMUST00000314713.1 ENSMUSG00000132889 ENSMUST00000314713.1 ENSMUSG00000132889 (from geneSymbol) uc335heg.1 uc335heg.1 
ENSMUST00000314722.1 ENSMUSG00000132890 ENSMUST00000314722.1 ENSMUSG00000132890 (from geneSymbol) uc335hep.1 uc335hep.1 
ENSMUST00000314723.1 ENSMUSG00000132891 ENSMUST00000314723.1 ENSMUSG00000132891 (from geneSymbol) uc335heq.1 uc335heq.1 
ENSMUST00000314731.1 ENSMUSG00000132892 ENSMUST00000314731.1 ENSMUSG00000132892 (from geneSymbol) uc335hey.1 uc335hey.1 
ENSMUST00000314732.1 ENSMUSG00000132893 ENSMUST00000314732.1 ENSMUSG00000132893 (from geneSymbol) uc335hez.1 uc335hez.1 
ENSMUST00000314733.1 ENSMUSG00000132894 ENSMUST00000314733.1 ENSMUSG00000132894 (from geneSymbol) uc335hfa.1 uc335hfa.1 
ENSMUST00000314737.1 ENSMUSG00000132895 ENSMUST00000314737.1 ENSMUSG00000132895 (from geneSymbol) uc335hfe.1 uc335hfe.1 
ENSMUST00000314738.1 ENSMUSG00000132896 ENSMUST00000314738.1 ENSMUSG00000132896 (from geneSymbol) uc335hff.1 uc335hff.1 
ENSMUST00000314740.1 ENSMUSG00000132897 ENSMUST00000314740.1 ENSMUSG00000132897 (from geneSymbol) uc335hfh.1 uc335hfh.1 
ENSMUST00000314741.1 ENSMUSG00000132898 ENSMUST00000314741.1 ENSMUSG00000132898 (from geneSymbol) uc335hfi.1 uc335hfi.1 
ENSMUST00000314747.1 ENSMUSG00000132899 ENSMUST00000314747.1 ENSMUSG00000132899 (from geneSymbol) uc335hfo.1 uc335hfo.1 
ENSMUST00000314750.1 Dnmt3bos ENSMUST00000314750.1 Dnmt3bos (from geneSymbol) AK033055 uc335hfr.1 uc335hfr.1 
ENSMUST00000314752.1 ENSMUSG00000132900 ENSMUST00000314752.1 ENSMUSG00000132900 (from geneSymbol) uc335hft.1 uc335hft.1 
ENSMUST00000314753.1 ENSMUSG00000132901 ENSMUST00000314753.1 ENSMUSG00000132901 (from geneSymbol) uc335hfu.1 uc335hfu.1 
ENSMUST00000314755.1 ENSMUSG00000132902 ENSMUST00000314755.1 ENSMUSG00000132902 (from geneSymbol) uc335hfw.1 uc335hfw.1 
ENSMUST00000314761.1 ENSMUSG00000132903 ENSMUST00000314761.1 ENSMUSG00000132903 (from geneSymbol) FV526394 uc335hgc.1 uc335hgc.1 
ENSMUST00000314762.1 Gm56566 ENSMUST00000314762.1 Gm56566 (from geneSymbol) uc335hgd.1 uc335hgd.1 
ENSMUST00000314763.1 ENSMUSG00000132904 ENSMUST00000314763.1 ENSMUSG00000132904 (from geneSymbol) uc335hge.1 uc335hge.1 
ENSMUST00000314765.1 ENSMUSG00000132905 ENSMUST00000314765.1 ENSMUSG00000132905 (from geneSymbol) uc335hgg.1 uc335hgg.1 
ENSMUST00000314767.1 Gm13091 ENSMUST00000314767.1 Gm13091 (from geneSymbol) uc335hgh.1 uc335hgh.1 
ENSMUST00000314770.1 ENSMUSG00000132907 ENSMUST00000314770.1 ENSMUSG00000132907 (from geneSymbol) uc335hgk.1 uc335hgk.1 
ENSMUST00000314774.1 ENSMUSG00000132908 ENSMUST00000314774.1 ENSMUSG00000132908 (from geneSymbol) uc335hgo.1 uc335hgo.1 
ENSMUST00000314793.1 ENSMUSG00000132909 ENSMUST00000314793.1 ENSMUSG00000132909 (from geneSymbol) uc335hhh.1 uc335hhh.1 
ENSMUST00000314800.1 ENSMUSG00000132910 ENSMUST00000314800.1 ENSMUSG00000132910 (from geneSymbol) uc335hho.1 uc335hho.1 
ENSMUST00000314804.1 ENSMUSG00000132911 ENSMUST00000314804.1 ENSMUSG00000132911 (from geneSymbol) uc335hhs.1 uc335hhs.1 
ENSMUST00000314808.1 ENSMUSG00000132912 ENSMUST00000314808.1 ENSMUSG00000132912 (from geneSymbol) uc335hhw.1 uc335hhw.1 
ENSMUST00000314810.1 ENSMUSG00000132913 ENSMUST00000314810.1 ENSMUSG00000132913 (from geneSymbol) uc335hhy.1 uc335hhy.1 
ENSMUST00000314811.1 ENSMUSG00000132914 ENSMUST00000314811.1 ENSMUSG00000132914 (from geneSymbol) uc335hhz.1 uc335hhz.1 
ENSMUST00000314823.1 Gm33940 ENSMUST00000314823.1 Gm33940 (from geneSymbol) uc335hik.1 uc335hik.1 
ENSMUST00000314825.1 ENSMUSG00000132916 ENSMUST00000314825.1 ENSMUSG00000132916 (from geneSymbol) AK131779 uc335him.1 uc335him.1 
ENSMUST00000314827.1 Gm57298 ENSMUST00000314827.1 Gm57298 (from geneSymbol) uc335hio.1 uc335hio.1 
ENSMUST00000314858.1 ENSMUSG00000132917 ENSMUST00000314858.1 ENSMUSG00000132917 (from geneSymbol) uc335hjt.1 uc335hjt.1 
ENSMUST00000314859.1 ENSMUSG00000132918 ENSMUST00000314859.1 ENSMUSG00000132918 (from geneSymbol) uc335hju.1 uc335hju.1 
ENSMUST00000314860.1 ENSMUSG00000132919 ENSMUST00000314860.1 ENSMUSG00000132919 (from geneSymbol) uc335hjv.1 uc335hjv.1 
ENSMUST00000314862.1 ENSMUSG00000132920 ENSMUST00000314862.1 ENSMUSG00000132920 (from geneSymbol) uc335hjx.1 uc335hjx.1 
ENSMUST00000314870.1 ENSMUSG00000132921 ENSMUST00000314870.1 ENSMUSG00000132921 (from geneSymbol) uc335hkf.1 uc335hkf.1 
ENSMUST00000314871.1 ENSMUSG00000132922 ENSMUST00000314871.1 ENSMUSG00000132922 (from geneSymbol) uc335hkg.1 uc335hkg.1 
ENSMUST00000314882.1 ENSMUSG00000132923 ENSMUST00000314882.1 ENSMUSG00000132923 (from geneSymbol) uc335hkr.1 uc335hkr.1 
ENSMUST00000314893.1 ENSMUSG00000132924 ENSMUST00000314893.1 ENSMUSG00000132924 (from geneSymbol) uc335hlb.1 uc335hlb.1 
ENSMUST00000314894.1 ENSMUSG00000132925 ENSMUST00000314894.1 ENSMUSG00000132925 (from geneSymbol) uc335hlc.1 uc335hlc.1 
ENSMUST00000314895.1 ENSMUSG00000132926 ENSMUST00000314895.1 ENSMUSG00000132926 (from geneSymbol) uc335hld.1 uc335hld.1 
ENSMUST00000314896.1 ENSMUSG00000132927 ENSMUST00000314896.1 ENSMUSG00000132927 (from geneSymbol) uc335hle.1 uc335hle.1 
ENSMUST00000314897.1 ENSMUSG00000132928 ENSMUST00000314897.1 ENSMUSG00000132928 (from geneSymbol) uc335hlf.1 uc335hlf.1 
ENSMUST00000314899.1 ENSMUSG00000132929 ENSMUST00000314899.1 ENSMUSG00000132929 (from geneSymbol) uc335hlh.1 uc335hlh.1 
ENSMUST00000314900.1 ENSMUSG00000132930 ENSMUST00000314900.1 ENSMUSG00000132930 (from geneSymbol) uc335hli.1 uc335hli.1 
ENSMUST00000314904.1 ENSMUSG00000132931 ENSMUST00000314904.1 ENSMUSG00000132931 (from geneSymbol) uc335hlm.1 uc335hlm.1 
ENSMUST00000314917.1 ENSMUSG00000132932 ENSMUST00000314917.1 ENSMUSG00000132932 (from geneSymbol) uc335hlz.1 uc335hlz.1 
ENSMUST00000314922.1 ENSMUSG00000132933 ENSMUST00000314922.1 ENSMUSG00000132933 (from geneSymbol) uc335hme.1 uc335hme.1 
ENSMUST00000314924.1 ENSMUSG00000132934 ENSMUST00000314924.1 ENSMUSG00000132934 (from geneSymbol) uc335hmg.1 uc335hmg.1 
ENSMUST00000314926.1 Gm48969 ENSMUST00000314926.1 Gm48969 (from geneSymbol) AK135432 uc335hmi.1 uc335hmi.1 
ENSMUST00000314965.1 ENSMUSG00000132935 ENSMUST00000314965.1 ENSMUSG00000132935 (from geneSymbol) uc335hnv.1 uc335hnv.1 
ENSMUST00000314966.1 ENSMUSG00000132936 ENSMUST00000314966.1 ENSMUSG00000132936 (from geneSymbol) uc335hnw.1 uc335hnw.1 
ENSMUST00000314977.1 Gm33680 ENSMUST00000314977.1 Gm33680 (from geneSymbol) AK079646 uc335hoh.1 uc335hoh.1 
ENSMUST00000314986.1 ENSMUSG00000132937 ENSMUST00000314986.1 ENSMUSG00000132937 (from geneSymbol) uc335hoq.1 uc335hoq.1 
ENSMUST00000314989.1 ENSMUSG00000132938 ENSMUST00000314989.1 ENSMUSG00000132938 (from geneSymbol) uc335hot.1 uc335hot.1 
ENSMUST00000314990.1 ENSMUSG00000132939 ENSMUST00000314990.1 ENSMUSG00000132939 (from geneSymbol) uc335hou.1 uc335hou.1 
ENSMUST00000314991.1 ENSMUSG00000132940 ENSMUST00000314991.1 ENSMUSG00000132940 (from geneSymbol) uc335hov.1 uc335hov.1 
ENSMUST00000314993.1 ENSMUSG00000132941 ENSMUST00000314993.1 ENSMUSG00000132941 (from geneSymbol) uc335hox.1 uc335hox.1 
ENSMUST00000315007.1 ENSMUSG00000132943 ENSMUST00000315007.1 ENSMUSG00000132943 (from geneSymbol) uc335hpk.1 uc335hpk.1 
ENSMUST00000315009.1 ENSMUSG00000132944 ENSMUST00000315009.1 ENSMUSG00000132944 (from geneSymbol) uc335hpm.1 uc335hpm.1 
ENSMUST00000315015.1 ENSMUSG00000132945 ENSMUST00000315015.1 ENSMUSG00000132945 (from geneSymbol) uc335hps.1 uc335hps.1 
ENSMUST00000315052.1 ENSMUSG00000132946 ENSMUST00000315052.1 ENSMUSG00000132946 (from geneSymbol) uc335hrc.1 uc335hrc.1 
ENSMUST00000315053.1 ENSMUSG00000132947 ENSMUST00000315053.1 ENSMUSG00000132947 (from geneSymbol) uc335hrd.1 uc335hrd.1 
ENSMUST00000315054.1 Gm37120 ENSMUST00000315054.1 Gm37120 (from geneSymbol) uc335hre.1 uc335hre.1 
ENSMUST00000315066.1 Gm32695 ENSMUST00000315066.1 Gm32695 (from geneSymbol) uc335hrq.1 uc335hrq.1 
ENSMUST00000315072.1 ENSMUSG00000132949 ENSMUST00000315072.1 ENSMUSG00000132949 (from geneSymbol) uc335hrw.1 uc335hrw.1 
ENSMUST00000315073.1 ENSMUSG00000132950 ENSMUST00000315073.1 ENSMUSG00000132950 (from geneSymbol) M18004 uc335hrx.1 uc335hrx.1 
ENSMUST00000315074.1 ENSMUSG00000132951 ENSMUST00000315074.1 ENSMUSG00000132951 (from geneSymbol) uc335hry.1 uc335hry.1 
ENSMUST00000315075.1 Gm57466 ENSMUST00000315075.1 Gm57466 (from geneSymbol) uc335hrz.1 uc335hrz.1 
ENSMUST00000315076.1 ENSMUSG00000132952 ENSMUST00000315076.1 ENSMUSG00000132952 (from geneSymbol) uc335hsa.1 uc335hsa.1 
ENSMUST00000315077.1 Gm13964 ENSMUST00000315077.1 Gm13964 (from geneSymbol) AK131757 uc335hsb.1 uc335hsb.1 
ENSMUST00000315081.1 ENSMUSG00000132953 ENSMUST00000315081.1 ENSMUSG00000132953 (from geneSymbol) uc335hsf.1 uc335hsf.1 
ENSMUST00000315084.1 ENSMUSG00000132954 ENSMUST00000315084.1 ENSMUSG00000132954 (from geneSymbol) uc335hsi.1 uc335hsi.1 
ENSMUST00000315094.1 Gm32235 ENSMUST00000315094.1 Gm32235 (from geneSymbol) uc335hss.1 uc335hss.1 
ENSMUST00000315113.1 ENSMUSG00000132955 ENSMUST00000315113.1 ENSMUSG00000132955 (from geneSymbol) uc335htl.1 uc335htl.1 
ENSMUST00000315116.1 ENSMUSG00000132956 ENSMUST00000315116.1 ENSMUSG00000132956 (from geneSymbol) uc335hto.1 uc335hto.1 
ENSMUST00000315117.1 ENSMUSG00000132957 ENSMUST00000315117.1 ENSMUSG00000132957 (from geneSymbol) uc335htp.1 uc335htp.1 
ENSMUST00000315118.1 ENSMUSG00000132958 ENSMUST00000315118.1 ENSMUSG00000132958 (from geneSymbol) uc335htq.1 uc335htq.1 
ENSMUST00000315121.1 Gm8013 ENSMUST00000315121.1 Gm8013 (from geneSymbol) AK171414 uc335htt.1 uc335htt.1 
ENSMUST00000315177.1 ENSMUSG00000132959 ENSMUST00000315177.1 ENSMUSG00000132959 (from geneSymbol) uc335hvx.1 uc335hvx.1 
ENSMUST00000315178.1 ENSMUSG00000132960 ENSMUST00000315178.1 ENSMUSG00000132960 (from geneSymbol) uc335hvy.1 uc335hvy.1 
ENSMUST00000315180.1 ENSMUSG00000132961 ENSMUST00000315180.1 ENSMUSG00000132961 (from geneSymbol) uc335hwa.1 uc335hwa.1 
ENSMUST00000315181.1 ENSMUSG00000132962 ENSMUST00000315181.1 ENSMUSG00000132962 (from geneSymbol) uc335hwb.1 uc335hwb.1 
ENSMUST00000315182.1 ENSMUSG00000132963 ENSMUST00000315182.1 ENSMUSG00000132963 (from geneSymbol) uc335hwc.1 uc335hwc.1 
ENSMUST00000315184.1 ENSMUSG00000132965 ENSMUST00000315184.1 ENSMUSG00000132965 (from geneSymbol) uc335hwd.1 uc335hwd.1 
ENSMUST00000315190.1 ENSMUSG00000132966 ENSMUST00000315190.1 ENSMUSG00000132966 (from geneSymbol) uc335hwj.1 uc335hwj.1 
ENSMUST00000315191.1 ENSMUSG00000132967 ENSMUST00000315191.1 ENSMUSG00000132967 (from geneSymbol) uc335hwk.1 uc335hwk.1 
ENSMUST00000315193.1 1700001K23Rik ENSMUST00000315193.1 1700001K23Rik (from geneSymbol) AK005607 uc335hwm.1 uc335hwm.1 
ENSMUST00000315264.1 ENSMUSG00000132968 ENSMUST00000315264.1 ENSMUSG00000132968 (from geneSymbol) DQ694443 uc335hzf.1 uc335hzf.1 
ENSMUST00000315265.1 ENSMUSG00000132969 ENSMUST00000315265.1 ENSMUSG00000132969 (from geneSymbol) uc335hzg.1 uc335hzg.1 
ENSMUST00000315268.1 ENSMUSG00000132970 ENSMUST00000315268.1 ENSMUSG00000132970 (from geneSymbol) uc335hzj.1 uc335hzj.1 
ENSMUST00000315269.1 ENSMUSG00000132971 ENSMUST00000315269.1 ENSMUSG00000132971 (from geneSymbol) uc335hzk.1 uc335hzk.1 
ENSMUST00000315270.1 ENSMUSG00000132972 ENSMUST00000315270.1 ENSMUSG00000132972 (from geneSymbol) uc335hzl.1 uc335hzl.1 
ENSMUST00000315277.1 ENSMUSG00000132973 ENSMUST00000315277.1 ENSMUSG00000132973 (from geneSymbol) uc335hzs.1 uc335hzs.1 
ENSMUST00000315278.1 ENSMUSG00000132974 ENSMUST00000315278.1 ENSMUSG00000132974 (from geneSymbol) uc335hzt.1 uc335hzt.1 
ENSMUST00000315279.1 ENSMUSG00000132975 ENSMUST00000315279.1 ENSMUSG00000132975 (from geneSymbol) AK131693 uc335hzu.1 uc335hzu.1 
ENSMUST00000315281.1 ENSMUSG00000132976 ENSMUST00000315281.1 ENSMUSG00000132976 (from geneSymbol) uc335hzw.1 uc335hzw.1 
ENSMUST00000315283.1 ENSMUSG00000132977 ENSMUST00000315283.1 ENSMUSG00000132977 (from geneSymbol) uc335hzy.1 uc335hzy.1 
ENSMUST00000315284.1 ENSMUSG00000132978 ENSMUST00000315284.1 ENSMUSG00000132978 (from geneSymbol) uc335hzz.1 uc335hzz.1 
ENSMUST00000315285.1 ENSMUSG00000132979 ENSMUST00000315285.1 ENSMUSG00000132979 (from geneSymbol) uc335iaa.1 uc335iaa.1 
ENSMUST00000315290.1 ENSMUSG00000132980 ENSMUST00000315290.1 ENSMUSG00000132980 (from geneSymbol) uc335iaf.1 uc335iaf.1 
ENSMUST00000315292.1 ENSMUSG00000132981 ENSMUST00000315292.1 ENSMUSG00000132981 (from geneSymbol) uc335iah.1 uc335iah.1 
ENSMUST00000315293.1 ENSMUSG00000132982 ENSMUST00000315293.1 ENSMUSG00000132982 (from geneSymbol) uc335iai.1 uc335iai.1 
ENSMUST00000315294.1 ENSMUSG00000132983 ENSMUST00000315294.1 ENSMUSG00000132983 (from geneSymbol) uc335iaj.1 uc335iaj.1 
ENSMUST00000315295.1 ENSMUSG00000132984 ENSMUST00000315295.1 ENSMUSG00000132984 (from geneSymbol) uc335iak.1 uc335iak.1 
ENSMUST00000315296.1 ENSMUSG00000132985 ENSMUST00000315296.1 ENSMUSG00000132985 (from geneSymbol) uc335ial.1 uc335ial.1 
ENSMUST00000315297.1 ENSMUSG00000132986 ENSMUST00000315297.1 ENSMUSG00000132986 (from geneSymbol) uc335iam.1 uc335iam.1 
ENSMUST00000315299.1 ENSMUSG00000132987 ENSMUST00000315299.1 ENSMUSG00000132987 (from geneSymbol) uc335iao.1 uc335iao.1 
ENSMUST00000315301.1 ENSMUSG00000132988 ENSMUST00000315301.1 ENSMUSG00000132988 (from geneSymbol) uc335iaq.1 uc335iaq.1 
ENSMUST00000315302.1 ENSMUSG00000132989 ENSMUST00000315302.1 ENSMUSG00000132989 (from geneSymbol) uc335iar.1 uc335iar.1 
ENSMUST00000315303.1 ENSMUSG00000132990 ENSMUST00000315303.1 ENSMUSG00000132990 (from geneSymbol) uc335ias.1 uc335ias.1 
ENSMUST00000315310.1 ENSMUSG00000132991 ENSMUST00000315310.1 ENSMUSG00000132991 (from geneSymbol) uc335iaz.1 uc335iaz.1 
ENSMUST00000315320.1 ENSMUSG00000132992 ENSMUST00000315320.1 ENSMUSG00000132992 (from geneSymbol) uc335ibj.1 uc335ibj.1 
ENSMUST00000315321.1 ENSMUSG00000132993 ENSMUST00000315321.1 ENSMUSG00000132993 (from geneSymbol) uc335ibk.1 uc335ibk.1 
ENSMUST00000315325.1 ENSMUSG00000132994 ENSMUST00000315325.1 ENSMUSG00000132994 (from geneSymbol) uc335ibo.1 uc335ibo.1 
ENSMUST00000315326.1 Gm45016 ENSMUST00000315326.1 Gm45016 (from geneSymbol) uc335ibp.1 uc335ibp.1 
ENSMUST00000315328.1 ENSMUSG00000132995 ENSMUST00000315328.1 ENSMUSG00000132995 (from geneSymbol) uc335ibr.1 uc335ibr.1 
ENSMUST00000315331.1 5830444B04Rik ENSMUST00000315331.1 5830444B04Rik (from geneSymbol) AK167606 uc335ibu.1 uc335ibu.1 
ENSMUST00000315341.1 ENSMUSG00000132996 ENSMUST00000315341.1 ENSMUSG00000132996 (from geneSymbol) uc335ice.1 uc335ice.1 
ENSMUST00000315345.1 ENSMUSG00000132997 ENSMUST00000315345.1 ENSMUSG00000132997 (from geneSymbol) uc335ici.1 uc335ici.1 
ENSMUST00000315346.1 ENSMUSG00000132998 ENSMUST00000315346.1 ENSMUSG00000132998 (from geneSymbol) uc335icj.1 uc335icj.1 
ENSMUST00000315348.1 ENSMUSG00000132999 ENSMUST00000315348.1 ENSMUSG00000132999 (from geneSymbol) uc335icl.1 uc335icl.1 
ENSMUST00000315349.1 ENSMUSG00000133000 ENSMUST00000315349.1 ENSMUSG00000133000 (from geneSymbol) uc335icm.1 uc335icm.1 
ENSMUST00000315351.1 ENSMUSG00000133001 ENSMUST00000315351.1 ENSMUSG00000133001 (from geneSymbol) uc335ico.1 uc335ico.1 
ENSMUST00000315353.1 ENSMUSG00000133002 ENSMUST00000315353.1 ENSMUSG00000133002 (from geneSymbol) uc335icq.1 uc335icq.1 
ENSMUST00000315355.1 ENSMUSG00000133003 ENSMUST00000315355.1 ENSMUSG00000133003 (from geneSymbol) uc335ics.1 uc335ics.1 
ENSMUST00000315356.1 ENSMUSG00000133004 ENSMUST00000315356.1 ENSMUSG00000133004 (from geneSymbol) uc335ict.1 uc335ict.1 
ENSMUST00000315357.1 ENSMUSG00000133005 ENSMUST00000315357.1 ENSMUSG00000133005 (from geneSymbol) uc335icu.1 uc335icu.1 
ENSMUST00000315360.1 ENSMUSG00000133006 ENSMUST00000315360.1 ENSMUSG00000133006 (from geneSymbol) uc335icx.1 uc335icx.1 
ENSMUST00000315363.1 ENSMUSG00000133007 ENSMUST00000315363.1 ENSMUSG00000133007 (from geneSymbol) uc335ida.1 uc335ida.1 
ENSMUST00000315367.1 ENSMUSG00000133008 ENSMUST00000315367.1 ENSMUSG00000133008 (from geneSymbol) AK171295 uc335ide.1 uc335ide.1 
ENSMUST00000315399.1 ENSMUSG00000133009 ENSMUST00000315399.1 ENSMUSG00000133009 (from geneSymbol) uc335iek.1 uc335iek.1 
ENSMUST00000315400.1 ENSMUSG00000133010 ENSMUST00000315400.1 ENSMUSG00000133010 (from geneSymbol) AK053050 uc335iel.1 uc335iel.1 
ENSMUST00000315405.1 ENSMUSG00000133011 ENSMUST00000315405.1 ENSMUSG00000133011 (from geneSymbol) uc335ieq.1 uc335ieq.1 
ENSMUST00000315406.1 Gm33370 ENSMUST00000315406.1 Gm33370 (from geneSymbol) uc335ier.1 uc335ier.1 
ENSMUST00000315416.1 ENSMUSG00000133012 ENSMUST00000315416.1 ENSMUSG00000133012 (from geneSymbol) uc335ifb.1 uc335ifb.1 
ENSMUST00000315450.1 ENSMUSG00000133013 ENSMUST00000315450.1 ENSMUSG00000133013 (from geneSymbol) uc335igj.1 uc335igj.1 
ENSMUST00000315451.1 ENSMUSG00000133014 ENSMUST00000315451.1 ENSMUSG00000133014 (from geneSymbol) uc335igk.1 uc335igk.1 
ENSMUST00000315457.1 ENSMUSG00000133015 ENSMUST00000315457.1 ENSMUSG00000133015 (from geneSymbol) uc335igq.1 uc335igq.1 
ENSMUST00000315458.1 Gm31087 ENSMUST00000315458.1 Gm31087 (from geneSymbol) BC049679 uc335igr.1 uc335igr.1 
ENSMUST00000315468.1 1700001J04Rik ENSMUST00000315468.1 1700001J04Rik (from geneSymbol) uc335ihb.1 uc335ihb.1 
ENSMUST00000315483.1 ENSMUSG00000133016 ENSMUST00000315483.1 ENSMUSG00000133016 (from geneSymbol) uc335ihq.1 uc335ihq.1 
ENSMUST00000315487.1 ENSMUSG00000133017 ENSMUST00000315487.1 ENSMUSG00000133017 (from geneSymbol) uc335ihu.1 uc335ihu.1 
ENSMUST00000315488.1 ENSMUSG00000133018 ENSMUST00000315488.1 ENSMUSG00000133018 (from geneSymbol) uc335ihv.1 uc335ihv.1 
ENSMUST00000315490.1 Gm12860 ENSMUST00000315490.1 Gm12860 (from geneSymbol) BC037762 uc335ihx.1 uc335ihx.1 
ENSMUST00000315519.1 ENSMUSG00000133019 ENSMUST00000315519.1 ENSMUSG00000133019 (from geneSymbol) uc335ija.1 uc335ija.1 
ENSMUST00000315524.1 ENSMUSG00000133020 ENSMUST00000315524.1 ENSMUSG00000133020 (from geneSymbol) uc335ijf.1 uc335ijf.1 
ENSMUST00000315533.1 ENSMUSG00000133021 ENSMUST00000315533.1 ENSMUSG00000133021 (from geneSymbol) uc335ijo.1 uc335ijo.1 
ENSMUST00000315546.1 ENSMUSG00000133022 ENSMUST00000315546.1 ENSMUSG00000133022 (from geneSymbol) uc335ikb.1 uc335ikb.1 
ENSMUST00000315547.1 ENSMUSG00000133023 ENSMUST00000315547.1 ENSMUSG00000133023 (from geneSymbol) uc335ikc.1 uc335ikc.1 
ENSMUST00000315550.1 ENSMUSG00000133024 ENSMUST00000315550.1 ENSMUSG00000133024 (from geneSymbol) uc335ikf.1 uc335ikf.1 
ENSMUST00000315551.1 ENSMUSG00000133025 ENSMUST00000315551.1 ENSMUSG00000133025 (from geneSymbol) uc335ikg.1 uc335ikg.1 
ENSMUST00000315571.1 ENSMUSG00000133026 ENSMUST00000315571.1 ENSMUSG00000133026 (from geneSymbol) uc335ila.1 uc335ila.1 
ENSMUST00000315578.1 Gm28543 ENSMUST00000315578.1 Gm28543 (from geneSymbol) uc335ilh.1 uc335ilh.1 
ENSMUST00000315594.1 ENSMUSG00000133027 ENSMUST00000315594.1 ENSMUSG00000133027 (from geneSymbol) uc335ilx.1 uc335ilx.1 
ENSMUST00000315596.1 ENSMUSG00000133028 ENSMUST00000315596.1 ENSMUSG00000133028 (from geneSymbol) uc335ilz.1 uc335ilz.1 
ENSMUST00000315597.1 ENSMUSG00000133029 ENSMUST00000315597.1 ENSMUSG00000133029 (from geneSymbol) uc335ima.1 uc335ima.1 
ENSMUST00000315602.1 ENSMUSG00000133031 ENSMUST00000315602.1 ENSMUSG00000133031 (from geneSymbol) uc335ime.1 uc335ime.1 
ENSMUST00000315606.1 ENSMUSG00000133032 ENSMUST00000315606.1 ENSMUSG00000133032 (from geneSymbol) uc335imi.1 uc335imi.1 
ENSMUST00000315613.1 ENSMUSG00000133033 ENSMUST00000315613.1 ENSMUSG00000133033 (from geneSymbol) uc335imp.1 uc335imp.1 
ENSMUST00000315615.1 ENSMUSG00000133034 ENSMUST00000315615.1 ENSMUSG00000133034 (from geneSymbol) uc335imr.1 uc335imr.1 
ENSMUST00000315616.1 ENSMUSG00000133035 ENSMUST00000315616.1 ENSMUSG00000133035 (from geneSymbol) uc335ims.1 uc335ims.1 
ENSMUST00000315619.1 ENSMUSG00000133036 ENSMUST00000315619.1 ENSMUSG00000133036 (from geneSymbol) uc335imv.1 uc335imv.1 
ENSMUST00000315620.1 ENSMUSG00000133037 ENSMUST00000315620.1 ENSMUSG00000133037 (from geneSymbol) uc335imw.1 uc335imw.1 
ENSMUST00000315621.1 ENSMUSG00000133038 ENSMUST00000315621.1 ENSMUSG00000133038 (from geneSymbol) uc335imx.1 uc335imx.1 
ENSMUST00000315624.1 ENSMUSG00000133039 ENSMUST00000315624.1 ENSMUSG00000133039 (from geneSymbol) uc335ina.1 uc335ina.1 
ENSMUST00000315625.1 ENSMUSG00000133040 ENSMUST00000315625.1 ENSMUSG00000133040 (from geneSymbol) uc335inb.1 uc335inb.1 
ENSMUST00000315628.1 ENSMUSG00000133041 ENSMUST00000315628.1 ENSMUSG00000133041 (from geneSymbol) uc335ine.1 uc335ine.1 
ENSMUST00000315629.1 2310081O03Rik ENSMUST00000315629.1 2310081O03Rik (from geneSymbol) AK010245 uc335inf.1 uc335inf.1 
ENSMUST00000315634.1 ENSMUSG00000133042 ENSMUST00000315634.1 ENSMUSG00000133042 (from geneSymbol) uc335ink.1 uc335ink.1 
ENSMUST00000315638.1 ENSMUSG00000133043 ENSMUST00000315638.1 ENSMUSG00000133043 (from geneSymbol) uc335ino.1 uc335ino.1 
ENSMUST00000315643.1 ENSMUSG00000133044 ENSMUST00000315643.1 ENSMUSG00000133044 (from geneSymbol) uc335int.1 uc335int.1 
ENSMUST00000315645.1 ENSMUSG00000133045 ENSMUST00000315645.1 ENSMUSG00000133045 (from geneSymbol) LF193316 uc335inv.1 uc335inv.1 
ENSMUST00000315647.1 ENSMUSG00000133046 ENSMUST00000315647.1 ENSMUSG00000133046 (from geneSymbol) uc335inx.1 uc335inx.1 
ENSMUST00000315649.1 Gm35135 ENSMUST00000315649.1 Gm35135 (from geneSymbol) AK138501 uc335inz.1 uc335inz.1 
ENSMUST00000315653.1 ENSMUSG00000133047 ENSMUST00000315653.1 ENSMUSG00000133047 (from geneSymbol) uc335iod.1 uc335iod.1 
ENSMUST00000315655.1 ENSMUSG00000133048 ENSMUST00000315655.1 ENSMUSG00000133048 (from geneSymbol) uc335iof.1 uc335iof.1 
ENSMUST00000315656.1 ENSMUSG00000133049 ENSMUST00000315656.1 ENSMUSG00000133049 (from geneSymbol) uc335iog.1 uc335iog.1 
ENSMUST00000315658.1 ENSMUSG00000133050 ENSMUST00000315658.1 ENSMUSG00000133050 (from geneSymbol) uc335ioi.1 uc335ioi.1 
ENSMUST00000315659.1 ENSMUSG00000133051 ENSMUST00000315659.1 ENSMUSG00000133051 (from geneSymbol) uc335ioj.1 uc335ioj.1 
ENSMUST00000315660.1 ENSMUSG00000133052 ENSMUST00000315660.1 ENSMUSG00000133052 (from geneSymbol) uc335iok.1 uc335iok.1 
ENSMUST00000315661.1 ENSMUSG00000133053 ENSMUST00000315661.1 ENSMUSG00000133053 (from geneSymbol) uc335iol.1 uc335iol.1 
ENSMUST00000315666.1 ENSMUSG00000133054 ENSMUST00000315666.1 ENSMUSG00000133054 (from geneSymbol) uc335ioq.1 uc335ioq.1 
ENSMUST00000315668.1 ENSMUSG00000133055 ENSMUST00000315668.1 ENSMUSG00000133055 (from geneSymbol) uc335ios.1 uc335ios.1 
ENSMUST00000315678.1 ENSMUSG00000133056 ENSMUST00000315678.1 ENSMUSG00000133056 (from geneSymbol) uc335ipc.1 uc335ipc.1 
ENSMUST00000315679.1 ENSMUSG00000133057 ENSMUST00000315679.1 ENSMUSG00000133057 (from geneSymbol) uc335ipd.1 uc335ipd.1 
ENSMUST00000315682.1 ENSMUSG00000133058 ENSMUST00000315682.1 ENSMUSG00000133058 (from geneSymbol) uc335ipg.1 uc335ipg.1 
ENSMUST00000315688.1 ENSMUSG00000133059 ENSMUST00000315688.1 ENSMUSG00000133059 (from geneSymbol) uc335ipm.1 uc335ipm.1 
ENSMUST00000315697.1 ENSMUSG00000133060 ENSMUST00000315697.1 ENSMUSG00000133060 (from geneSymbol) uc335ipv.1 uc335ipv.1 
ENSMUST00000315700.1 ENSMUSG00000133061 ENSMUST00000315700.1 ENSMUSG00000133061 (from geneSymbol) uc335ipy.1 uc335ipy.1 
ENSMUST00000315704.1 ENSMUSG00000133062 ENSMUST00000315704.1 ENSMUSG00000133062 (from geneSymbol) uc335iqc.1 uc335iqc.1 
ENSMUST00000315705.1 ENSMUSG00000133063 ENSMUST00000315705.1 ENSMUSG00000133063 (from geneSymbol) uc335iqd.1 uc335iqd.1 
ENSMUST00000315713.1 ENSMUSG00000133064 ENSMUST00000315713.1 ENSMUSG00000133064 (from geneSymbol) uc335iql.1 uc335iql.1 
ENSMUST00000315716.1 ENSMUSG00000133065 ENSMUST00000315716.1 ENSMUSG00000133065 (from geneSymbol) uc335iqo.1 uc335iqo.1 
ENSMUST00000315724.1 Gm30239 ENSMUST00000315724.1 Gm30239 (from geneSymbol) AK046182 uc335iqw.1 uc335iqw.1 
ENSMUST00000315732.1 ENSMUSG00000133066 ENSMUST00000315732.1 ENSMUSG00000133066 (from geneSymbol) uc335ire.1 uc335ire.1 
ENSMUST00000315733.1 ENSMUSG00000133067 ENSMUST00000315733.1 ENSMUSG00000133067 (from geneSymbol) uc335irf.1 uc335irf.1 
ENSMUST00000315734.1 ENSMUSG00000133068 ENSMUST00000315734.1 ENSMUSG00000133068 (from geneSymbol) uc335irg.1 uc335irg.1 
ENSMUST00000315736.1 ENSMUSG00000133069 ENSMUST00000315736.1 ENSMUSG00000133069 (from geneSymbol) uc335iri.1 uc335iri.1 
ENSMUST00000315737.1 ENSMUSG00000133070 ENSMUST00000315737.1 ENSMUSG00000133070 (from geneSymbol) AK035940 uc335irj.1 uc335irj.1 
ENSMUST00000315739.1 ENSMUSG00000133071 ENSMUST00000315739.1 ENSMUSG00000133071 (from geneSymbol) AK083149 uc335irl.1 uc335irl.1 
ENSMUST00000315740.1 ENSMUSG00000133072 ENSMUST00000315740.1 ENSMUSG00000133072 (from geneSymbol) uc335irm.1 uc335irm.1 
ENSMUST00000315741.1 ENSMUSG00000133073 ENSMUST00000315741.1 ENSMUSG00000133073 (from geneSymbol) uc335irn.1 uc335irn.1 
ENSMUST00000315744.1 ENSMUSG00000133074 ENSMUST00000315744.1 ENSMUSG00000133074 (from geneSymbol) uc335irq.1 uc335irq.1 
ENSMUST00000315745.1 ENSMUSG00000133075 ENSMUST00000315745.1 ENSMUSG00000133075 (from geneSymbol) uc335irr.1 uc335irr.1 
ENSMUST00000315746.1 ENSMUSG00000133076 ENSMUST00000315746.1 ENSMUSG00000133076 (from geneSymbol) uc335irs.1 uc335irs.1 
ENSMUST00000315756.1 ENSMUSG00000133077 ENSMUST00000315756.1 ENSMUSG00000133077 (from geneSymbol) uc335isc.1 uc335isc.1 
ENSMUST00000315757.1 ENSMUSG00000133078 ENSMUST00000315757.1 ENSMUSG00000133078 (from geneSymbol) uc335isd.1 uc335isd.1 
ENSMUST00000315758.1 ENSMUSG00000133079 ENSMUST00000315758.1 ENSMUSG00000133079 (from geneSymbol) uc335ise.1 uc335ise.1 
ENSMUST00000315764.1 Gm57065 ENSMUST00000315764.1 Gm57065 (from geneSymbol) uc335isk.1 uc335isk.1 
ENSMUST00000315768.1 ENSMUSG00000133080 ENSMUST00000315768.1 ENSMUSG00000133080 (from geneSymbol) uc335iso.1 uc335iso.1 
ENSMUST00000315770.1 ENSMUSG00000133081 ENSMUST00000315770.1 ENSMUSG00000133081 (from geneSymbol) uc335isq.1 uc335isq.1 
ENSMUST00000315779.1 ENSMUSG00000133082 ENSMUST00000315779.1 ENSMUSG00000133082 (from geneSymbol) uc335isz.1 uc335isz.1 
ENSMUST00000315781.1 D630024D03Rik ENSMUST00000315781.1 D630024D03Rik (from geneSymbol) KY467577 uc335itb.1 uc335itb.1 
ENSMUST00000315823.1 ENSMUSG00000133083 ENSMUST00000315823.1 ENSMUSG00000133083 (from geneSymbol) uc335iur.1 uc335iur.1 
ENSMUST00000315824.1 ENSMUSG00000133084 ENSMUST00000315824.1 ENSMUSG00000133084 (from geneSymbol) uc335ius.1 uc335ius.1 
ENSMUST00000315825.1 ENSMUSG00000133085 ENSMUST00000315825.1 ENSMUSG00000133085 (from geneSymbol) uc335iut.1 uc335iut.1 
ENSMUST00000315826.1 Gm41533 ENSMUST00000315826.1 Gm41533 (from geneSymbol) AK131733 uc335iuu.1 uc335iuu.1 
ENSMUST00000315832.1 ENSMUSG00000133087 ENSMUST00000315832.1 ENSMUSG00000133087 (from geneSymbol) uc335iva.1 uc335iva.1 
ENSMUST00000315833.1 ENSMUSG00000133088 ENSMUST00000315833.1 ENSMUSG00000133088 (from geneSymbol) uc335ivb.1 uc335ivb.1 
ENSMUST00000315858.1 ENSMUSG00000133089 ENSMUST00000315858.1 ENSMUSG00000133089 (from geneSymbol) uc335iwa.1 uc335iwa.1 
ENSMUST00000315862.1 ENSMUSG00000133090 ENSMUST00000315862.1 ENSMUSG00000133090 (from geneSymbol) uc335iwe.1 uc335iwe.1 
ENSMUST00000315863.1 ENSMUSG00000133091 ENSMUST00000315863.1 ENSMUSG00000133091 (from geneSymbol) uc335iwf.1 uc335iwf.1 
ENSMUST00000315864.1 ENSMUSG00000133092 ENSMUST00000315864.1 ENSMUSG00000133092 (from geneSymbol) uc335iwg.1 uc335iwg.1 
ENSMUST00000315870.1 ENSMUSG00000133093 ENSMUST00000315870.1 ENSMUSG00000133093 (from geneSymbol) uc335iwm.1 uc335iwm.1 
ENSMUST00000315876.1 ENSMUSG00000133094 ENSMUST00000315876.1 ENSMUSG00000133094 (from geneSymbol) uc335iws.1 uc335iws.1 
ENSMUST00000315877.1 ENSMUSG00000133095 ENSMUST00000315877.1 ENSMUSG00000133095 (from geneSymbol) uc335iwt.1 uc335iwt.1 
ENSMUST00000315879.1 Gm20610 ENSMUST00000315879.1 Gm20610 (from geneSymbol) uc335iwv.1 uc335iwv.1 
ENSMUST00000315908.1 ENSMUSG00000133096 ENSMUST00000315908.1 ENSMUSG00000133096 (from geneSymbol) uc335ixy.1 uc335ixy.1 
ENSMUST00000315909.1 ENSMUSG00000133097 ENSMUST00000315909.1 ENSMUSG00000133097 (from geneSymbol) uc335ixz.1 uc335ixz.1 
ENSMUST00000315918.1 1700123O12Rik ENSMUST00000315918.1 1700123O12Rik (from geneSymbol) AK007260 uc335iyi.1 uc335iyi.1 
ENSMUST00000315951.1 ENSMUSG00000133098 ENSMUST00000315951.1 ENSMUSG00000133098 (from geneSymbol) uc335izp.1 uc335izp.1 
ENSMUST00000315960.1 ENSMUSG00000133099 ENSMUST00000315960.1 ENSMUSG00000133099 (from geneSymbol) uc335izy.1 uc335izy.1 
ENSMUST00000315964.1 ENSMUSG00000133100 ENSMUST00000315964.1 ENSMUSG00000133100 (from geneSymbol) uc335jac.1 uc335jac.1 
ENSMUST00000315971.1 ENSMUSG00000133101 ENSMUST00000315971.1 ENSMUSG00000133101 (from geneSymbol) uc335jaj.1 uc335jaj.1 
ENSMUST00000315972.1 ENSMUSG00000133102 ENSMUST00000315972.1 ENSMUSG00000133102 (from geneSymbol) uc335jak.1 uc335jak.1 
ENSMUST00000315973.1 ENSMUSG00000133103 ENSMUST00000315973.1 ENSMUSG00000133103 (from geneSymbol) uc335jal.1 uc335jal.1 
ENSMUST00000315974.1 ENSMUSG00000133104 ENSMUST00000315974.1 ENSMUSG00000133104 (from geneSymbol) uc335jam.1 uc335jam.1 
ENSMUST00000315977.1 ENSMUSG00000133105 ENSMUST00000315977.1 ENSMUSG00000133105 (from geneSymbol) uc335jap.1 uc335jap.1 
ENSMUST00000315978.1 ENSMUSG00000133106 ENSMUST00000315978.1 ENSMUSG00000133106 (from geneSymbol) uc335jaq.1 uc335jaq.1 
ENSMUST00000315992.1 ENSMUSG00000133107 ENSMUST00000315992.1 ENSMUSG00000133107 (from geneSymbol) uc335jbe.1 uc335jbe.1 
ENSMUST00000315994.1 ENSMUSG00000133108 ENSMUST00000315994.1 ENSMUSG00000133108 (from geneSymbol) uc335jbg.1 uc335jbg.1 
ENSMUST00000316003.1 ENSMUSG00000133109 ENSMUST00000316003.1 ENSMUSG00000133109 (from geneSymbol) uc335jbp.1 uc335jbp.1 
ENSMUST00000316030.1 ENSMUSG00000133110 ENSMUST00000316030.1 ENSMUSG00000133110 (from geneSymbol) uc335jcq.1 uc335jcq.1 
ENSMUST00000316031.1 ENSMUSG00000133111 ENSMUST00000316031.1 ENSMUSG00000133111 (from geneSymbol) uc335jcr.1 uc335jcr.1 
ENSMUST00000316033.1 ENSMUSG00000133112 ENSMUST00000316033.1 ENSMUSG00000133112 (from geneSymbol) uc335jct.1 uc335jct.1 
ENSMUST00000316034.1 ENSMUSG00000133113 ENSMUST00000316034.1 ENSMUSG00000133113 (from geneSymbol) uc335jcu.1 uc335jcu.1 
ENSMUST00000316035.1 ENSMUSG00000133114 ENSMUST00000316035.1 ENSMUSG00000133114 (from geneSymbol) uc335jcv.1 uc335jcv.1 
ENSMUST00000316036.1 ENSMUSG00000133115 ENSMUST00000316036.1 ENSMUSG00000133115 (from geneSymbol) uc335jcw.1 uc335jcw.1 
ENSMUST00000316037.1 ENSMUSG00000133116 ENSMUST00000316037.1 ENSMUSG00000133116 (from geneSymbol) uc335jcx.1 uc335jcx.1 
ENSMUST00000316038.1 Gm56790 ENSMUST00000316038.1 Gm56790 (from geneSymbol) uc335jcy.1 uc335jcy.1 
ENSMUST00000316043.1 ENSMUSG00000133117 ENSMUST00000316043.1 ENSMUSG00000133117 (from geneSymbol) AK006016 uc335jdd.1 uc335jdd.1 
ENSMUST00000316045.1 ENSMUSG00000133118 ENSMUST00000316045.1 ENSMUSG00000133118 (from geneSymbol) uc335jdf.1 uc335jdf.1 
ENSMUST00000316047.1 ENSMUSG00000133119 ENSMUST00000316047.1 ENSMUSG00000133119 (from geneSymbol) uc335jdh.1 uc335jdh.1 
ENSMUST00000316048.1 Gm29482 ENSMUST00000316048.1 Gm29482 (from geneSymbol) uc335jdi.1 uc335jdi.1 
ENSMUST00000316056.1 Gm29007 ENSMUST00000316056.1 Gm29007 (from geneSymbol) uc335jdq.1 uc335jdq.1 
ENSMUST00000316061.1 ENSMUSG00000133120 ENSMUST00000316061.1 ENSMUSG00000133120 (from geneSymbol) uc335jdv.1 uc335jdv.1 
ENSMUST00000316062.1 ENSMUSG00000133121 ENSMUST00000316062.1 ENSMUSG00000133121 (from geneSymbol) uc335jdw.1 uc335jdw.1 
ENSMUST00000316064.1 ENSMUSG00000133122 ENSMUST00000316064.1 ENSMUSG00000133122 (from geneSymbol) uc335jdy.1 uc335jdy.1 
ENSMUST00000316066.1 ENSMUSG00000133123 ENSMUST00000316066.1 ENSMUSG00000133123 (from geneSymbol) uc335jea.1 uc335jea.1 
ENSMUST00000316069.1 ENSMUSG00000133124 ENSMUST00000316069.1 ENSMUSG00000133124 (from geneSymbol) uc335jed.1 uc335jed.1 
ENSMUST00000316070.1 ENSMUSG00000133125 ENSMUST00000316070.1 ENSMUSG00000133125 (from geneSymbol) uc335jee.1 uc335jee.1 
ENSMUST00000316071.1 Gm57371 ENSMUST00000316071.1 Gm57371 (from geneSymbol) uc335jef.1 uc335jef.1 
ENSMUST00000316078.1 Gm29202 ENSMUST00000316078.1 Gm29202 (from geneSymbol) uc335jem.1 uc335jem.1 
ENSMUST00000316083.1 ENSMUSG00000133126 ENSMUST00000316083.1 ENSMUSG00000133126 (from geneSymbol) uc335jer.1 uc335jer.1 
ENSMUST00000316084.1 ENSMUSG00000133127 ENSMUST00000316084.1 ENSMUSG00000133127 (from geneSymbol) uc335jes.1 uc335jes.1 
ENSMUST00000316085.1 ENSMUSG00000133128 ENSMUST00000316085.1 ENSMUSG00000133128 (from geneSymbol) uc335jet.1 uc335jet.1 
ENSMUST00000316086.1 ENSMUSG00000133129 ENSMUST00000316086.1 ENSMUSG00000133129 (from geneSymbol) uc335jeu.1 uc335jeu.1 
ENSMUST00000316090.1 ENSMUSG00000133130 ENSMUST00000316090.1 ENSMUSG00000133130 (from geneSymbol) uc335jey.1 uc335jey.1 
ENSMUST00000316091.1 ENSMUSG00000133131 ENSMUST00000316091.1 ENSMUSG00000133131 (from geneSymbol) uc335jez.1 uc335jez.1 
ENSMUST00000316097.1 Gm49415 ENSMUST00000316097.1 Gm49415 (from geneSymbol) AK084492 uc335jff.1 uc335jff.1 
ENSMUST00000316100.1 ENSMUSG00000133132 ENSMUST00000316100.1 ENSMUSG00000133132 (from geneSymbol) uc335jfi.1 uc335jfi.1 
ENSMUST00000316113.1 ENSMUSG00000133133 ENSMUST00000316113.1 ENSMUSG00000133133 (from geneSymbol) uc335jfv.1 uc335jfv.1 
ENSMUST00000316135.1 ENSMUSG00000133134 ENSMUST00000316135.1 ENSMUSG00000133134 (from geneSymbol) uc335jgr.1 uc335jgr.1 
ENSMUST00000316150.1 ENSMUSG00000133135 ENSMUST00000316150.1 ENSMUSG00000133135 (from geneSymbol) uc335jhg.1 uc335jhg.1 
ENSMUST00000316156.1 0610033M10Rik ENSMUST00000316156.1 0610033M10Rik (from geneSymbol) AK002748 uc335jhm.1 uc335jhm.1 
ENSMUST00000316162.1 ENSMUSG00000133136 ENSMUST00000316162.1 ENSMUSG00000133136 (from geneSymbol) uc335jhs.1 uc335jhs.1 
ENSMUST00000316163.1 1010001B22Rik ENSMUST00000316163.1 1010001B22Rik (from geneSymbol) AK003103 uc335jht.1 uc335jht.1 
ENSMUST00000316168.1 ENSMUSG00000133137 ENSMUST00000316168.1 ENSMUSG00000133137 (from geneSymbol) uc335jhy.1 uc335jhy.1 
ENSMUST00000316175.1 ENSMUSG00000133138 ENSMUST00000316175.1 ENSMUSG00000133138 (from geneSymbol) uc335jif.1 uc335jif.1 
ENSMUST00000316179.1 Gm20611 ENSMUST00000316179.1 Gm20611 (from geneSymbol) AK029795 uc335jij.1 uc335jij.1 
ENSMUST00000316190.1 ENSMUSG00000133139 ENSMUST00000316190.1 ENSMUSG00000133139 (from geneSymbol) uc335jiu.1 uc335jiu.1 
ENSMUST00000316191.1 ENSMUSG00000133140 ENSMUST00000316191.1 ENSMUSG00000133140 (from geneSymbol) uc335jiv.1 uc335jiv.1 
ENSMUST00000316196.1 ENSMUSG00000133141 ENSMUST00000316196.1 ENSMUSG00000133141 (from geneSymbol) uc335jja.1 uc335jja.1 
ENSMUST00000316204.1 ENSMUSG00000133142 ENSMUST00000316204.1 ENSMUSG00000133142 (from geneSymbol) uc335jji.1 uc335jji.1 
ENSMUST00000316205.1 ENSMUSG00000133143 ENSMUST00000316205.1 ENSMUSG00000133143 (from geneSymbol) uc335jjj.1 uc335jjj.1 
ENSMUST00000316206.1 ENSMUSG00000133144 ENSMUST00000316206.1 ENSMUSG00000133144 (from geneSymbol) uc335jjk.1 uc335jjk.1 
ENSMUST00000316208.1 1700016B01Rik ENSMUST00000316208.1 1700016B01Rik (from geneSymbol) AK006010 uc335jjm.1 uc335jjm.1 
ENSMUST00000316211.1 ENSMUSG00000133145 ENSMUST00000316211.1 ENSMUSG00000133145 (from geneSymbol) uc335jjp.1 uc335jjp.1 
ENSMUST00000316212.1 ENSMUSG00000133146 ENSMUST00000316212.1 ENSMUSG00000133146 (from geneSymbol) LF194626 uc335jjq.1 uc335jjq.1 
ENSMUST00000316213.1 ENSMUSG00000133147 ENSMUST00000316213.1 ENSMUSG00000133147 (from geneSymbol) uc335jjr.1 uc335jjr.1 
ENSMUST00000316228.1 ENSMUSG00000133149 ENSMUST00000316228.1 ENSMUSG00000133149 (from geneSymbol) uc335jkf.1 uc335jkf.1 
ENSMUST00000316229.1 Gm31466 ENSMUST00000316229.1 Gm31466 (from geneSymbol) uc335jkg.1 uc335jkg.1 
ENSMUST00000316241.1 ENSMUSG00000133150 ENSMUST00000316241.1 ENSMUSG00000133150 (from geneSymbol) uc335jks.1 uc335jks.1 
ENSMUST00000316247.1 ENSMUSG00000133151 ENSMUST00000316247.1 ENSMUSG00000133151 (from geneSymbol) uc335jky.1 uc335jky.1 
ENSMUST00000316248.1 ENSMUSG00000133152 ENSMUST00000316248.1 ENSMUSG00000133152 (from geneSymbol) uc335jkz.1 uc335jkz.1 
ENSMUST00000316249.1 ENSMUSG00000133153 ENSMUST00000316249.1 ENSMUSG00000133153 (from geneSymbol) uc335jla.1 uc335jla.1 
ENSMUST00000316251.1 ENSMUSG00000133154 ENSMUST00000316251.1 ENSMUSG00000133154 (from geneSymbol) uc335jlc.1 uc335jlc.1 
ENSMUST00000316252.1 ENSMUSG00000133155 ENSMUST00000316252.1 ENSMUSG00000133155 (from geneSymbol) uc335jld.1 uc335jld.1 
ENSMUST00000316253.1 Gm48616 ENSMUST00000316253.1 Gm48616 (from geneSymbol) uc335jle.1 uc335jle.1 
ENSMUST00000316264.1 ENSMUSG00000133156 ENSMUST00000316264.1 ENSMUSG00000133156 (from geneSymbol) uc335jlp.1 uc335jlp.1 
ENSMUST00000316270.1 Gm30933 ENSMUST00000316270.1 Gm30933 (from geneSymbol) uc335jlv.1 uc335jlv.1 
ENSMUST00000316272.1 Gm12865 ENSMUST00000316272.1 Gm12865 (from geneSymbol) uc335jlx.1 uc335jlx.1 
ENSMUST00000316281.1 ENSMUSG00000133157 ENSMUST00000316281.1 ENSMUSG00000133157 (from geneSymbol) uc335jmf.1 uc335jmf.1 
ENSMUST00000316282.1 ENSMUSG00000133158 ENSMUST00000316282.1 ENSMUSG00000133158 (from geneSymbol) uc335jmg.1 uc335jmg.1 
ENSMUST00000316283.1 ENSMUSG00000133159 ENSMUST00000316283.1 ENSMUSG00000133159 (from geneSymbol) uc335jmh.1 uc335jmh.1 
ENSMUST00000316288.1 Gm19497 ENSMUST00000316288.1 Gm19497 (from geneSymbol) uc335jml.1 uc335jml.1 
ENSMUST00000316304.1 ENSMUSG00000133160 ENSMUST00000316304.1 ENSMUSG00000133160 (from geneSymbol) uc335jnb.1 uc335jnb.1 
ENSMUST00000316305.1 ENSMUSG00000133161 ENSMUST00000316305.1 ENSMUSG00000133161 (from geneSymbol) uc335jnc.1 uc335jnc.1 
ENSMUST00000316309.1 ENSMUSG00000133162 ENSMUST00000316309.1 ENSMUSG00000133162 (from geneSymbol) uc335jng.1 uc335jng.1 
ENSMUST00000316315.1 ENSMUSG00000133163 ENSMUST00000316315.1 ENSMUSG00000133163 (from geneSymbol) uc335jnm.1 uc335jnm.1 
ENSMUST00000316316.1 ENSMUSG00000133164 ENSMUST00000316316.1 ENSMUSG00000133164 (from geneSymbol) AK050857 uc335jnn.1 uc335jnn.1 
ENSMUST00000316317.1 Trmt61b ENSMUST00000316317.1 Trmt61b (from geneSymbol) AK032413 uc335jno.1 uc335jno.1 
ENSMUST00000316332.1 ENSMUSG00000133165 ENSMUST00000316332.1 ENSMUSG00000133165 (from geneSymbol) uc335jod.1 uc335jod.1 
ENSMUST00000316345.1 ENSMUSG00000133166 ENSMUST00000316345.1 ENSMUSG00000133166 (from geneSymbol) uc335joq.1 uc335joq.1 
ENSMUST00000316350.1 ENSMUSG00000133168 ENSMUST00000316350.1 ENSMUSG00000133168 (from geneSymbol) uc335jou.1 uc335jou.1 
ENSMUST00000316351.1 ENSMUSG00000133169 ENSMUST00000316351.1 ENSMUSG00000133169 (from geneSymbol) uc335jov.1 uc335jov.1 
ENSMUST00000316357.1 Gm57366 ENSMUST00000316357.1 Gm57366 (from geneSymbol) uc335jpb.1 uc335jpb.1 
ENSMUST00000316366.1 ENSMUSG00000133170 ENSMUST00000316366.1 ENSMUSG00000133170 (from geneSymbol) uc335jpk.1 uc335jpk.1 
ENSMUST00000316373.1 ENSMUSG00000133171 ENSMUST00000316373.1 ENSMUSG00000133171 (from geneSymbol) uc335jpr.1 uc335jpr.1 
ENSMUST00000316374.1 ENSMUSG00000133172 ENSMUST00000316374.1 ENSMUSG00000133172 (from geneSymbol) uc335jps.1 uc335jps.1 
ENSMUST00000316375.1 ENSMUSG00000133173 ENSMUST00000316375.1 ENSMUSG00000133173 (from geneSymbol) uc335jpt.1 uc335jpt.1 
ENSMUST00000316382.1 ENSMUSG00000133174 ENSMUST00000316382.1 ENSMUSG00000133174 (from geneSymbol) uc335jqa.1 uc335jqa.1 
ENSMUST00000316386.1 ENSMUSG00000133175 ENSMUST00000316386.1 ENSMUSG00000133175 (from geneSymbol) uc335jqe.1 uc335jqe.1 
ENSMUST00000316388.1 ENSMUSG00000133176 ENSMUST00000316388.1 ENSMUSG00000133176 (from geneSymbol) uc335jqg.1 uc335jqg.1 
ENSMUST00000316389.1 ENSMUSG00000133177 ENSMUST00000316389.1 ENSMUSG00000133177 (from geneSymbol) uc335jqh.1 uc335jqh.1 
ENSMUST00000316392.1 ENSMUSG00000133178 ENSMUST00000316392.1 ENSMUSG00000133178 (from geneSymbol) uc335jqk.1 uc335jqk.1 
ENSMUST00000316393.1 ENSMUSG00000133179 ENSMUST00000316393.1 ENSMUSG00000133179 (from geneSymbol) uc335jql.1 uc335jql.1 
ENSMUST00000316394.1 ENSMUSG00000133180 ENSMUST00000316394.1 ENSMUSG00000133180 (from geneSymbol) uc335jqm.1 uc335jqm.1 
ENSMUST00000316421.1 ENSMUSG00000133181 ENSMUST00000316421.1 ENSMUSG00000133181 (from geneSymbol) uc335jrn.1 uc335jrn.1 
ENSMUST00000316424.1 ENSMUSG00000133182 ENSMUST00000316424.1 ENSMUSG00000133182 (from geneSymbol) uc335jrq.1 uc335jrq.1 
ENSMUST00000316427.1 ENSMUSG00000133183 ENSMUST00000316427.1 ENSMUSG00000133183 (from geneSymbol) uc335jrt.1 uc335jrt.1 
ENSMUST00000316428.1 ENSMUSG00000133184 ENSMUST00000316428.1 ENSMUSG00000133184 (from geneSymbol) uc335jru.1 uc335jru.1 
ENSMUST00000316429.1 ENSMUSG00000133185 ENSMUST00000316429.1 ENSMUSG00000133185 (from geneSymbol) uc335jrv.1 uc335jrv.1 
ENSMUST00000316461.1 ENSMUSG00000133186 ENSMUST00000316461.1 ENSMUSG00000133186 (from geneSymbol) uc335jtb.1 uc335jtb.1 
ENSMUST00000316462.1 ENSMUSG00000133187 ENSMUST00000316462.1 ENSMUSG00000133187 (from geneSymbol) uc335jtc.1 uc335jtc.1 
ENSMUST00000316463.1 ENSMUSG00000133188 ENSMUST00000316463.1 ENSMUSG00000133188 (from geneSymbol) uc335jtd.1 uc335jtd.1 
ENSMUST00000316474.1 Gm26725 ENSMUST00000316474.1 Gm26725 (from geneSymbol) AK078730 uc335jto.1 uc335jto.1 
ENSMUST00000316513.1 ENSMUSG00000133189 ENSMUST00000316513.1 ENSMUSG00000133189 (from geneSymbol) uc335jvb.1 uc335jvb.1 
ENSMUST00000316514.1 ENSMUSG00000133190 ENSMUST00000316514.1 ENSMUSG00000133190 (from geneSymbol) uc335jvc.1 uc335jvc.1 
ENSMUST00000316515.1 ENSMUSG00000133191 ENSMUST00000316515.1 ENSMUSG00000133191 (from geneSymbol) uc335jvd.1 uc335jvd.1 
ENSMUST00000316520.1 Gm38545 ENSMUST00000316520.1 predicted gene, 38545, transcript variant 2 (from RefSeq NR_168615.1) NR_168615 uc335jvi.1 uc335jvi.1 
ENSMUST00000316528.1 ENSMUSG00000133193 ENSMUST00000316528.1 ENSMUSG00000133193 (from geneSymbol) uc335jvq.1 uc335jvq.1 
ENSMUST00000316533.1 Gm12320 ENSMUST00000316533.1 Gm12320 (from geneSymbol) AK039373 uc335jvv.1 uc335jvv.1 
ENSMUST00000316535.1 ENSMUSG00000133194 ENSMUST00000316535.1 ENSMUSG00000133194 (from geneSymbol) uc335jvx.1 uc335jvx.1 
ENSMUST00000316537.1 ENSMUSG00000133195 ENSMUST00000316537.1 ENSMUSG00000133195 (from geneSymbol) uc335jvz.1 uc335jvz.1 
ENSMUST00000316538.1 ENSMUSG00000133196 ENSMUST00000316538.1 ENSMUSG00000133196 (from geneSymbol) uc335jwa.1 uc335jwa.1 
ENSMUST00000316539.1 ENSMUSG00000133197 ENSMUST00000316539.1 ENSMUSG00000133197 (from geneSymbol) uc335jwb.1 uc335jwb.1 
ENSMUST00000316540.1 ENSMUSG00000133198 ENSMUST00000316540.1 ENSMUSG00000133198 (from geneSymbol) uc335jwc.1 uc335jwc.1 
ENSMUST00000316543.1 ENSMUSG00000133199 ENSMUST00000316543.1 ENSMUSG00000133199 (from geneSymbol) uc335jwf.1 uc335jwf.1 
ENSMUST00000316544.1 Gm36406 ENSMUST00000316544.1 Gm36406 (from geneSymbol) uc335jwg.1 uc335jwg.1 
ENSMUST00000316563.1 Gm43507 ENSMUST00000316563.1 Gm43507 (from geneSymbol) AK033337 uc335jwz.1 uc335jwz.1 
ENSMUST00000316567.1 ENSMUSG00000133200 ENSMUST00000316567.1 ENSMUSG00000133200 (from geneSymbol) uc335jxd.1 uc335jxd.1 
ENSMUST00000316568.1 ENSMUSG00000133201 ENSMUST00000316568.1 ENSMUSG00000133201 (from geneSymbol) uc335jxe.1 uc335jxe.1 
ENSMUST00000316569.1 Gm31974 ENSMUST00000316569.1 Gm31974 (from geneSymbol) uc335jxf.1 uc335jxf.1 
ENSMUST00000316577.1 ENSMUSG00000133202 ENSMUST00000316577.1 ENSMUSG00000133202 (from geneSymbol) uc335jxn.1 uc335jxn.1 
ENSMUST00000316578.1 ENSMUSG00000133203 ENSMUST00000316578.1 ENSMUSG00000133203 (from geneSymbol) uc335jxo.1 uc335jxo.1 
ENSMUST00000316580.1 ENSMUSG00000133204 ENSMUST00000316580.1 ENSMUSG00000133204 (from geneSymbol) uc335jxq.1 uc335jxq.1 
ENSMUST00000316581.1 ENSMUSG00000133205 ENSMUST00000316581.1 ENSMUSG00000133205 (from geneSymbol) uc335jxr.1 uc335jxr.1 
ENSMUST00000316585.1 ENSMUSG00000133206 ENSMUST00000316585.1 ENSMUSG00000133206 (from geneSymbol) LF198616 uc335jxv.1 uc335jxv.1 
ENSMUST00000316587.1 ENSMUSG00000133207 ENSMUST00000316587.1 ENSMUSG00000133207 (from geneSymbol) uc335jxx.1 uc335jxx.1 
ENSMUST00000316589.1 ENSMUSG00000133208 ENSMUST00000316589.1 ENSMUSG00000133208 (from geneSymbol) uc335jxz.1 uc335jxz.1 
ENSMUST00000316603.1 ENSMUSG00000133210 ENSMUST00000316603.1 ENSMUSG00000133210 (from geneSymbol) uc335jyj.1 uc335jyj.1 
ENSMUST00000316605.1 ENSMUSG00000133211 ENSMUST00000316605.1 ENSMUSG00000133211 (from geneSymbol) uc335jyl.1 uc335jyl.1 
ENSMUST00000316606.1 Gm40572 ENSMUST00000316606.1 Gm40572 (from geneSymbol) uc335jym.1 uc335jym.1 
ENSMUST00000316609.1 ENSMUSG00000133212 ENSMUST00000316609.1 ENSMUSG00000133212 (from geneSymbol) uc335jyp.1 uc335jyp.1 
ENSMUST00000316613.1 ENSMUSG00000133213 ENSMUST00000316613.1 ENSMUSG00000133213 (from geneSymbol) uc335jyt.1 uc335jyt.1 
ENSMUST00000316619.1 ENSMUSG00000133214 ENSMUST00000316619.1 ENSMUSG00000133214 (from geneSymbol) uc335jyz.1 uc335jyz.1 
ENSMUST00000316623.1 ENSMUSG00000133215 ENSMUST00000316623.1 ENSMUSG00000133215 (from geneSymbol) BC062266 uc335jzd.1 uc335jzd.1 
ENSMUST00000316627.1 ENSMUSG00000133216 ENSMUST00000316627.1 ENSMUSG00000133216 (from geneSymbol) uc335jzh.1 uc335jzh.1 
ENSMUST00000316629.1 Gm48483 ENSMUST00000316629.1 Gm48483 (from geneSymbol) uc335jzj.1 uc335jzj.1 
ENSMUST00000316630.1 ENSMUSG00000133217 ENSMUST00000316630.1 ENSMUSG00000133217 (from geneSymbol) uc335jzk.1 uc335jzk.1 
ENSMUST00000316631.1 ENSMUSG00000133218 ENSMUST00000316631.1 ENSMUSG00000133218 (from geneSymbol) uc335jzl.1 uc335jzl.1 
ENSMUST00000316634.1 ENSMUSG00000133219 ENSMUST00000316634.1 ENSMUSG00000133219 (from geneSymbol) uc335jzo.1 uc335jzo.1 
ENSMUST00000316637.1 1700069L16Rik ENSMUST00000316637.1 1700069L16Rik (from geneSymbol) AK007096 uc335jzr.1 uc335jzr.1 
ENSMUST00000316648.1 Gm38575 ENSMUST00000316648.1 Gm38575 (from geneSymbol) AK038448 uc335kac.1 uc335kac.1 
ENSMUST00000316657.1 ENSMUSG00000133220 ENSMUST00000316657.1 ENSMUSG00000133220 (from geneSymbol) uc335kal.1 uc335kal.1 
ENSMUST00000316660.1 ENSMUSG00000133221 ENSMUST00000316660.1 ENSMUSG00000133221 (from geneSymbol) uc335kao.1 uc335kao.1 
ENSMUST00000316661.1 ENSMUSG00000133222 ENSMUST00000316661.1 ENSMUSG00000133222 (from geneSymbol) uc335kap.1 uc335kap.1 
ENSMUST00000316662.1 ENSMUSG00000133223 ENSMUST00000316662.1 ENSMUSG00000133223 (from geneSymbol) uc335kaq.1 uc335kaq.1 
ENSMUST00000316674.1 ENSMUSG00000133224 ENSMUST00000316674.1 ENSMUSG00000133224 (from geneSymbol) uc335kbc.1 uc335kbc.1 
ENSMUST00000316676.1 ENSMUSG00000133225 ENSMUST00000316676.1 ENSMUSG00000133225 (from geneSymbol) uc335kbe.1 uc335kbe.1 
ENSMUST00000316678.1 ENSMUSG00000133226 ENSMUST00000316678.1 ENSMUSG00000133226 (from geneSymbol) uc335kbg.1 uc335kbg.1 
ENSMUST00000316681.1 ENSMUSG00000133227 ENSMUST00000316681.1 ENSMUSG00000133227 (from geneSymbol) uc335kbj.1 uc335kbj.1 
ENSMUST00000316683.1 ENSMUSG00000133228 ENSMUST00000316683.1 ENSMUSG00000133228 (from geneSymbol) uc335kbl.1 uc335kbl.1 
ENSMUST00000316684.1 ENSMUSG00000133229 ENSMUST00000316684.1 ENSMUSG00000133229 (from geneSymbol) uc335kbm.1 uc335kbm.1 
ENSMUST00000316686.1 ENSMUSG00000133230 ENSMUST00000316686.1 ENSMUSG00000133230 (from geneSymbol) uc335kbn.1 uc335kbn.1 
ENSMUST00000316690.1 ENSMUSG00000133231 ENSMUST00000316690.1 ENSMUSG00000133231 (from geneSymbol) uc335kbr.1 uc335kbr.1 
ENSMUST00000316708.1 ENSMUSG00000133232 ENSMUST00000316708.1 ENSMUSG00000133232 (from geneSymbol) uc335kcj.1 uc335kcj.1 
ENSMUST00000316709.1 ENSMUSG00000133233 ENSMUST00000316709.1 ENSMUSG00000133233 (from geneSymbol) uc335kck.1 uc335kck.1 
ENSMUST00000316710.1 ENSMUSG00000133234 ENSMUST00000316710.1 ENSMUSG00000133234 (from geneSymbol) uc335kcl.1 uc335kcl.1 
ENSMUST00000316711.1 ENSMUSG00000133235 ENSMUST00000316711.1 ENSMUSG00000133235 (from geneSymbol) uc335kcm.1 uc335kcm.1 
ENSMUST00000316712.1 ENSMUSG00000133236 ENSMUST00000316712.1 ENSMUSG00000133236 (from geneSymbol) uc335kcn.1 uc335kcn.1 
ENSMUST00000316714.1 ENSMUSG00000133237 ENSMUST00000316714.1 ENSMUSG00000133237 (from geneSymbol) uc335kcp.1 uc335kcp.1 
ENSMUST00000316715.1 ENSMUSG00000133238 ENSMUST00000316715.1 ENSMUSG00000133238 (from geneSymbol) BC051642 uc335kcq.1 uc335kcq.1 
ENSMUST00000316716.1 ENSMUSG00000133239 ENSMUST00000316716.1 ENSMUSG00000133239 (from geneSymbol) uc335kcr.1 uc335kcr.1 
ENSMUST00000316717.1 ENSMUSG00000133240 ENSMUST00000316717.1 ENSMUSG00000133240 (from geneSymbol) uc335kcs.1 uc335kcs.1 
ENSMUST00000316721.1 ENSMUSG00000133241 ENSMUST00000316721.1 ENSMUSG00000133241 (from geneSymbol) uc335kcw.1 uc335kcw.1 
ENSMUST00000316723.1 ENSMUSG00000133242 ENSMUST00000316723.1 ENSMUSG00000133242 (from geneSymbol) uc335kcy.1 uc335kcy.1 
ENSMUST00000316724.1 ENSMUSG00000133243 ENSMUST00000316724.1 ENSMUSG00000133243 (from geneSymbol) uc335kcz.1 uc335kcz.1 
ENSMUST00000316725.1 ENSMUSG00000133244 ENSMUST00000316725.1 ENSMUSG00000133244 (from geneSymbol) uc335kda.1 uc335kda.1 
ENSMUST00000316726.1 ENSMUSG00000133245 ENSMUST00000316726.1 ENSMUSG00000133245 (from geneSymbol) uc335kdb.1 uc335kdb.1 
ENSMUST00000316727.1 ENSMUSG00000133246 ENSMUST00000316727.1 ENSMUSG00000133246 (from geneSymbol) uc335kdc.1 uc335kdc.1 
ENSMUST00000316728.1 ENSMUSG00000133247 ENSMUST00000316728.1 ENSMUSG00000133247 (from geneSymbol) uc335kdd.1 uc335kdd.1 
ENSMUST00000316729.1 ENSMUSG00000133248 ENSMUST00000316729.1 ENSMUSG00000133248 (from geneSymbol) uc335kde.1 uc335kde.1 
ENSMUST00000316732.1 Sox5os1 ENSMUST00000316732.1 Sox5os1 (from geneSymbol) AK016816 uc335kdh.1 uc335kdh.1 
ENSMUST00000316737.1 ENSMUSG00000133249 ENSMUST00000316737.1 ENSMUSG00000133249 (from geneSymbol) uc335kdm.1 uc335kdm.1 
ENSMUST00000316742.1 Gpr137b-ps ENSMUST00000316742.1 Gpr137b-ps (from geneSymbol) AF154337 uc335kdr.1 uc335kdr.1 
ENSMUST00000316764.1 ENSMUSG00000133250 ENSMUST00000316764.1 ENSMUSG00000133250 (from geneSymbol) uc335kel.1 uc335kel.1 
ENSMUST00000316765.1 ENSMUSG00000133251 ENSMUST00000316765.1 ENSMUSG00000133251 (from geneSymbol) uc335kem.1 uc335kem.1 
ENSMUST00000316770.1 ENSMUSG00000133253 ENSMUST00000316770.1 ENSMUSG00000133253 (from geneSymbol) uc335keo.1 uc335keo.1 
ENSMUST00000316771.1 ENSMUSG00000133254 ENSMUST00000316771.1 ENSMUSG00000133254 (from geneSymbol) uc335kep.1 uc335kep.1 
ENSMUST00000316775.1 ENSMUSG00000133256 ENSMUST00000316775.1 ENSMUSG00000133256 (from geneSymbol) uc335ker.1 uc335ker.1 
ENSMUST00000316776.1 ENSMUSG00000133257 ENSMUST00000316776.1 ENSMUSG00000133257 (from geneSymbol) uc335kes.1 uc335kes.1 
ENSMUST00000316777.1 ENSMUSG00000133258 ENSMUST00000316777.1 ENSMUSG00000133258 (from geneSymbol) uc335ket.1 uc335ket.1 
ENSMUST00000316800.1 ENSMUSG00000133259 ENSMUST00000316800.1 ENSMUSG00000133259 (from geneSymbol) uc335kfq.1 uc335kfq.1 
ENSMUST00000316801.1 ENSMUSG00000133260 ENSMUST00000316801.1 ENSMUSG00000133260 (from geneSymbol) uc335kfr.1 uc335kfr.1 
ENSMUST00000316803.1 ENSMUSG00000133261 ENSMUST00000316803.1 ENSMUSG00000133261 (from geneSymbol) AK083376 uc335kft.1 uc335kft.1 
ENSMUST00000316805.1 ENSMUSG00000133262 ENSMUST00000316805.1 ENSMUSG00000133262 (from geneSymbol) uc335kfv.1 uc335kfv.1 
ENSMUST00000316806.1 ENSMUSG00000133263 ENSMUST00000316806.1 ENSMUSG00000133263 (from geneSymbol) uc335kfw.1 uc335kfw.1 
ENSMUST00000316808.1 ENSMUSG00000133264 ENSMUST00000316808.1 ENSMUSG00000133264 (from geneSymbol) uc335kfy.1 uc335kfy.1 
ENSMUST00000316809.1 ENSMUSG00000133265 ENSMUST00000316809.1 ENSMUSG00000133265 (from geneSymbol) uc335kfz.1 uc335kfz.1 
ENSMUST00000316810.1 ENSMUSG00000133266 ENSMUST00000316810.1 ENSMUSG00000133266 (from geneSymbol) AK020054 uc335kga.1 uc335kga.1 
ENSMUST00000316813.1 ENSMUSG00000133267 ENSMUST00000316813.1 ENSMUSG00000133267 (from geneSymbol) uc335kgd.1 uc335kgd.1 
ENSMUST00000316814.1 ENSMUSG00000133268 ENSMUST00000316814.1 ENSMUSG00000133268 (from geneSymbol) uc335kge.1 uc335kge.1 
ENSMUST00000316815.1 ENSMUSG00000133269 ENSMUST00000316815.1 ENSMUSG00000133269 (from geneSymbol) uc335kgf.1 uc335kgf.1 
ENSMUST00000316818.1 ENSMUSG00000133270 ENSMUST00000316818.1 ENSMUSG00000133270 (from geneSymbol) uc335kgi.1 uc335kgi.1 
ENSMUST00000316820.1 ENSMUSG00000133272 ENSMUST00000316820.1 ENSMUSG00000133272 (from geneSymbol) AK133687 uc335kgj.1 uc335kgj.1 
ENSMUST00000316822.1 ENSMUSG00000133273 ENSMUST00000316822.1 ENSMUSG00000133273 (from geneSymbol) uc335kgl.1 uc335kgl.1 
ENSMUST00000316832.1 ENSMUSG00000133274 ENSMUST00000316832.1 ENSMUSG00000133274 (from geneSymbol) uc335kgv.1 uc335kgv.1 
ENSMUST00000316833.1 ENSMUSG00000133275 ENSMUST00000316833.1 ENSMUSG00000133275 (from geneSymbol) uc335kgw.1 uc335kgw.1 
ENSMUST00000316834.1 ENSMUSG00000133276 ENSMUST00000316834.1 ENSMUSG00000133276 (from geneSymbol) uc335kgx.1 uc335kgx.1 
ENSMUST00000316835.1 ENSMUSG00000133277 ENSMUST00000316835.1 ENSMUSG00000133277 (from geneSymbol) uc335kgy.1 uc335kgy.1 
ENSMUST00000316836.1 ENSMUSG00000133278 ENSMUST00000316836.1 ENSMUSG00000133278 (from geneSymbol) uc335kgz.1 uc335kgz.1 
ENSMUST00000316839.1 ENSMUSG00000133279 ENSMUST00000316839.1 ENSMUSG00000133279 (from geneSymbol) uc335khc.1 uc335khc.1 
ENSMUST00000316840.1 ENSMUSG00000133280 ENSMUST00000316840.1 ENSMUSG00000133280 (from geneSymbol) uc335khd.1 uc335khd.1 
ENSMUST00000316844.1 AW046200 ENSMUST00000316844.1 AW046200 (from geneSymbol) AK038453 uc335khh.1 uc335khh.1 
ENSMUST00000316854.1 ENSMUSG00000133281 ENSMUST00000316854.1 ENSMUSG00000133281 (from geneSymbol) uc335khr.1 uc335khr.1 
ENSMUST00000316857.1 ENSMUSG00000133282 ENSMUST00000316857.1 ENSMUSG00000133282 (from geneSymbol) uc335khu.1 uc335khu.1 
ENSMUST00000316861.1 ENSMUSG00000133283 ENSMUST00000316861.1 ENSMUSG00000133283 (from geneSymbol) uc335khy.1 uc335khy.1 
ENSMUST00000316862.1 6720470G18Rik ENSMUST00000316862.1 6720470G18Rik (from geneSymbol) uc335khz.1 uc335khz.1 
ENSMUST00000316867.1 ENSMUSG00000133284 ENSMUST00000316867.1 ENSMUSG00000133284 (from geneSymbol) uc335kie.1 uc335kie.1 
ENSMUST00000316872.1 Gm26586 ENSMUST00000316872.1 Gm26586 (from geneSymbol) AK139980 uc335kij.1 uc335kij.1 
ENSMUST00000316883.1 ENSMUSG00000133285 ENSMUST00000316883.1 ENSMUSG00000133285 (from geneSymbol) uc335kiu.1 uc335kiu.1 
ENSMUST00000316888.1 ENSMUSG00000133286 ENSMUST00000316888.1 ENSMUSG00000133286 (from geneSymbol) uc335kiz.1 uc335kiz.1 
ENSMUST00000316889.1 Gm15569 ENSMUST00000316889.1 Gm15569 (from geneSymbol) uc335kja.1 uc335kja.1 
ENSMUST00000316900.1 ENSMUSG00000133287 ENSMUST00000316900.1 ENSMUSG00000133287 (from geneSymbol) uc335kjl.1 uc335kjl.1 
ENSMUST00000316917.1 Gm29185 ENSMUST00000316917.1 Gm29185 (from geneSymbol) uc335kkc.1 uc335kkc.1 
ENSMUST00000316945.1 ENSMUSG00000133288 ENSMUST00000316945.1 ENSMUSG00000133288 (from geneSymbol) uc335kle.1 uc335kle.1 
ENSMUST00000316951.1 ENSMUSG00000133290 ENSMUST00000316951.1 ENSMUSG00000133290 (from geneSymbol) uc335klg.1 uc335klg.1 
ENSMUST00000316952.1 ENSMUSG00000133291 ENSMUST00000316952.1 ENSMUSG00000133291 (from geneSymbol) uc335klh.1 uc335klh.1 
ENSMUST00000316958.1 ENSMUSG00000133292 ENSMUST00000316958.1 ENSMUSG00000133292 (from geneSymbol) uc335kln.1 uc335kln.1 
ENSMUST00000316960.1 ENSMUSG00000133293 ENSMUST00000316960.1 ENSMUSG00000133293 (from geneSymbol) uc335klp.1 uc335klp.1 
ENSMUST00000316961.1 ENSMUSG00000133294 ENSMUST00000316961.1 ENSMUSG00000133294 (from geneSymbol) uc335klq.1 uc335klq.1 
ENSMUST00000316963.1 ENSMUSG00000133295 ENSMUST00000316963.1 ENSMUSG00000133295 (from geneSymbol) uc335kls.1 uc335kls.1 
ENSMUST00000317001.1 ENSMUSG00000133296 ENSMUST00000317001.1 ENSMUSG00000133296 (from geneSymbol) uc335kne.1 uc335kne.1 
ENSMUST00000317006.1 ENSMUSG00000133298 ENSMUST00000317006.1 ENSMUSG00000133298 (from geneSymbol) uc335kni.1 uc335kni.1 
ENSMUST00000317014.1 Gm34917 ENSMUST00000317014.1 Gm34917 (from geneSymbol) uc335knq.1 uc335knq.1 
ENSMUST00000317034.1 ENSMUSG00000133299 ENSMUST00000317034.1 ENSMUSG00000133299 (from geneSymbol) uc335kok.1 uc335kok.1 
ENSMUST00000317035.1 ENSMUSG00000133300 ENSMUST00000317035.1 ENSMUSG00000133300 (from geneSymbol) uc335kol.1 uc335kol.1 
ENSMUST00000317040.1 ENSMUSG00000133301 ENSMUST00000317040.1 ENSMUSG00000133301 (from geneSymbol) AK044196 uc335koq.1 uc335koq.1 
ENSMUST00000317048.1 A930041C12Rik ENSMUST00000317048.1 A930041C12Rik (from geneSymbol) AK020948 uc335koy.1 uc335koy.1 
ENSMUST00000317052.1 ENSMUSG00000133302 ENSMUST00000317052.1 ENSMUSG00000133302 (from geneSymbol) uc335kpc.1 uc335kpc.1 
ENSMUST00000317054.1 ENSMUSG00000133303 ENSMUST00000317054.1 ENSMUSG00000133303 (from geneSymbol) uc335kpe.1 uc335kpe.1 
ENSMUST00000317055.1 ENSMUSG00000133304 ENSMUST00000317055.1 ENSMUSG00000133304 (from geneSymbol) uc335kpf.1 uc335kpf.1 
ENSMUST00000317056.1 ENSMUSG00000133305 ENSMUST00000317056.1 ENSMUSG00000133305 (from geneSymbol) uc335kpg.1 uc335kpg.1 
ENSMUST00000317057.1 ENSMUSG00000133306 ENSMUST00000317057.1 ENSMUSG00000133306 (from geneSymbol) uc335kph.1 uc335kph.1 
ENSMUST00000317059.1 ENSMUSG00000133307 ENSMUST00000317059.1 ENSMUSG00000133307 (from geneSymbol) uc335kpj.1 uc335kpj.1 
ENSMUST00000317063.1 ENSMUSG00000133308 ENSMUST00000317063.1 ENSMUSG00000133308 (from geneSymbol) uc335kpn.1 uc335kpn.1 
ENSMUST00000317064.1 ENSMUSG00000133309 ENSMUST00000317064.1 ENSMUSG00000133309 (from geneSymbol) uc335kpo.1 uc335kpo.1 
ENSMUST00000317065.1 ENSMUSG00000133310 ENSMUST00000317065.1 ENSMUSG00000133310 (from geneSymbol) uc335kpp.1 uc335kpp.1 
ENSMUST00000317066.1 ENSMUSG00000133311 ENSMUST00000317066.1 ENSMUSG00000133311 (from geneSymbol) uc335kpq.1 uc335kpq.1 
ENSMUST00000317081.1 Gm38883 ENSMUST00000317081.1 Gm38883 (from geneSymbol) uc335kqf.1 uc335kqf.1 
ENSMUST00000317087.1 ENSMUSG00000133313 ENSMUST00000317087.1 ENSMUSG00000133313 (from geneSymbol) uc335kql.1 uc335kql.1 
ENSMUST00000317089.1 ENSMUSG00000133314 ENSMUST00000317089.1 ENSMUSG00000133314 (from geneSymbol) uc335kqn.1 uc335kqn.1 
ENSMUST00000317090.1 ENSMUSG00000133315 ENSMUST00000317090.1 ENSMUSG00000133315 (from geneSymbol) uc335kqo.1 uc335kqo.1 
ENSMUST00000317091.1 ENSMUSG00000133316 ENSMUST00000317091.1 ENSMUSG00000133316 (from geneSymbol) uc335kqp.1 uc335kqp.1 
ENSMUST00000317092.1 ENSMUSG00000133317 ENSMUST00000317092.1 ENSMUSG00000133317 (from geneSymbol) uc335kqq.1 uc335kqq.1 
ENSMUST00000317093.1 4930439D14Rik ENSMUST00000317093.1 4930439D14Rik (from geneSymbol) uc335kqr.1 uc335kqr.1 
ENSMUST00000317097.1 ENSMUSG00000133319 ENSMUST00000317097.1 ENSMUSG00000133319 (from geneSymbol) uc335kqv.1 uc335kqv.1 
ENSMUST00000317099.1 A830019L24Rik ENSMUST00000317099.1 A830019L24Rik (from geneSymbol) AK086499 uc335kqx.1 uc335kqx.1 
ENSMUST00000317109.1 ENSMUSG00000133320 ENSMUST00000317109.1 ENSMUSG00000133320 (from geneSymbol) uc335krh.1 uc335krh.1 
ENSMUST00000317111.1 ENSMUSG00000133321 ENSMUST00000317111.1 ENSMUSG00000133321 (from geneSymbol) uc335kri.1 uc335kri.1 
ENSMUST00000317118.1 1700028D13Rik ENSMUST00000317118.1 RIKEN cDNA 1700028D13 gene, transcript variant 1 (from RefSeq NR_045377.1) NR_045377 uc335krp.1 uc335krp.1 
ENSMUST00000317127.1 ENSMUSG00000133322 ENSMUST00000317127.1 ENSMUSG00000133322 (from geneSymbol) uc335kry.1 uc335kry.1 
ENSMUST00000317128.1 ENSMUSG00000133323 ENSMUST00000317128.1 ENSMUSG00000133323 (from geneSymbol) uc335krz.1 uc335krz.1 
ENSMUST00000317129.1 ENSMUSG00000133324 ENSMUST00000317129.1 ENSMUSG00000133324 (from geneSymbol) uc335ksa.1 uc335ksa.1 
ENSMUST00000317130.1 ENSMUSG00000133325 ENSMUST00000317130.1 ENSMUSG00000133325 (from geneSymbol) uc335ksb.1 uc335ksb.1 
ENSMUST00000317133.1 ENSMUSG00000133326 ENSMUST00000317133.1 ENSMUSG00000133326 (from geneSymbol) AK049212 uc335ksc.1 uc335ksc.1 
ENSMUST00000317145.1 ENSMUSG00000133328 ENSMUST00000317145.1 ENSMUSG00000133328 (from geneSymbol) LF203255 uc335ksm.1 uc335ksm.1 
ENSMUST00000317146.1 ENSMUSG00000133329 ENSMUST00000317146.1 ENSMUSG00000133329 (from geneSymbol) uc335ksn.1 uc335ksn.1 
ENSMUST00000317149.1 ENSMUSG00000133330 ENSMUST00000317149.1 ENSMUSG00000133330 (from geneSymbol) uc335ksq.1 uc335ksq.1 
ENSMUST00000317163.1 ENSMUSG00000133331 ENSMUST00000317163.1 ENSMUSG00000133331 (from geneSymbol) uc335ktd.1 uc335ktd.1 
ENSMUST00000317184.1 ENSMUSG00000133332 ENSMUST00000317184.1 ENSMUSG00000133332 (from geneSymbol) uc335kty.1 uc335kty.1 
ENSMUST00000317196.1 Gm13387 ENSMUST00000317196.1 Gm13387 (from geneSymbol) KY467838 uc335kuj.1 uc335kuj.1 
ENSMUST00000317202.1 E130006D01Rik ENSMUST00000317202.1 E130006D01Rik (from geneSymbol) AK087393 uc335kuo.1 uc335kuo.1 
ENSMUST00000317229.1 ENSMUSG00000133335 ENSMUST00000317229.1 ENSMUSG00000133335 (from geneSymbol) uc335kvp.1 uc335kvp.1 
ENSMUST00000317230.1 ENSMUSG00000133336 ENSMUST00000317230.1 ENSMUSG00000133336 (from geneSymbol) uc335kvq.1 uc335kvq.1 
ENSMUST00000317232.1 Gm38186 ENSMUST00000317232.1 Gm38186 (from geneSymbol) uc335kvs.1 uc335kvs.1 
ENSMUST00000317235.1 ENSMUSG00000133337 ENSMUST00000317235.1 ENSMUSG00000133337 (from geneSymbol) uc335kvv.1 uc335kvv.1 
ENSMUST00000317236.1 ENSMUSG00000133338 ENSMUST00000317236.1 ENSMUSG00000133338 (from geneSymbol) uc335kvw.1 uc335kvw.1 
ENSMUST00000317239.1 ENSMUSG00000133340 ENSMUST00000317239.1 ENSMUSG00000133340 (from geneSymbol) uc335kvy.1 uc335kvy.1 
ENSMUST00000317246.1 ENSMUSG00000133341 ENSMUST00000317246.1 ENSMUSG00000133341 (from geneSymbol) uc335kwf.1 uc335kwf.1 
ENSMUST00000317248.1 ENSMUSG00000133342 ENSMUST00000317248.1 ENSMUSG00000133342 (from geneSymbol) uc335kwh.1 uc335kwh.1 
ENSMUST00000317249.1 ENSMUSG00000133343 ENSMUST00000317249.1 ENSMUSG00000133343 (from geneSymbol) uc335kwi.1 uc335kwi.1 
ENSMUST00000317257.1 ENSMUSG00000133344 ENSMUST00000317257.1 ENSMUSG00000133344 (from geneSymbol) KY468253 uc335kwq.1 uc335kwq.1 
ENSMUST00000317268.1 ENSMUSG00000133345 ENSMUST00000317268.1 ENSMUSG00000133345 (from geneSymbol) uc335kxb.1 uc335kxb.1 
ENSMUST00000317270.1 ENSMUSG00000133346 ENSMUST00000317270.1 ENSMUSG00000133346 (from geneSymbol) uc335kxd.1 uc335kxd.1 
ENSMUST00000317271.1 ENSMUSG00000133347 ENSMUST00000317271.1 ENSMUSG00000133347 (from geneSymbol) uc335kxe.1 uc335kxe.1 
ENSMUST00000317272.1 ENSMUSG00000133348 ENSMUST00000317272.1 ENSMUSG00000133348 (from geneSymbol) uc335kxf.1 uc335kxf.1 
ENSMUST00000317273.1 ENSMUSG00000133349 ENSMUST00000317273.1 ENSMUSG00000133349 (from geneSymbol) uc335kxg.1 uc335kxg.1 
ENSMUST00000317275.1 ENSMUSG00000133350 ENSMUST00000317275.1 ENSMUSG00000133350 (from geneSymbol) uc335kxi.1 uc335kxi.1 
ENSMUST00000317276.1 ENSMUSG00000133351 ENSMUST00000317276.1 ENSMUSG00000133351 (from geneSymbol) uc335kxj.1 uc335kxj.1 
ENSMUST00000317277.1 Gm38882 ENSMUST00000317277.1 Gm38882 (from geneSymbol) uc335kxk.1 uc335kxk.1 
ENSMUST00000317285.1 ENSMUSG00000133352 ENSMUST00000317285.1 ENSMUSG00000133352 (from geneSymbol) AK082813 uc335kxs.1 uc335kxs.1 
ENSMUST00000317301.1 ENSMUSG00000133353 ENSMUST00000317301.1 ENSMUSG00000133353 (from geneSymbol) uc335kyi.1 uc335kyi.1 
ENSMUST00000317303.1 ENSMUSG00000133354 ENSMUST00000317303.1 ENSMUSG00000133354 (from geneSymbol) uc335kyk.1 uc335kyk.1 
ENSMUST00000317304.1 ENSMUSG00000133355 ENSMUST00000317304.1 ENSMUSG00000133355 (from geneSymbol) uc335kyl.1 uc335kyl.1 
ENSMUST00000317305.1 4930474N09Rik ENSMUST00000317305.1 4930474N09Rik (from geneSymbol) AK015577 uc335kym.1 uc335kym.1 
ENSMUST00000317308.1 ENSMUSG00000133356 ENSMUST00000317308.1 ENSMUSG00000133356 (from geneSymbol) uc335kyp.1 uc335kyp.1 
ENSMUST00000317310.1 ENSMUSG00000133357 ENSMUST00000317310.1 ENSMUSG00000133357 (from geneSymbol) uc335kyr.1 uc335kyr.1 
ENSMUST00000317328.1 ENSMUSG00000133358 ENSMUST00000317328.1 ENSMUSG00000133358 (from geneSymbol) uc335kzj.1 uc335kzj.1 
ENSMUST00000317329.1 ENSMUSG00000133359 ENSMUST00000317329.1 ENSMUSG00000133359 (from geneSymbol) uc335kzk.1 uc335kzk.1 
ENSMUST00000317331.1 ENSMUSG00000133360 ENSMUST00000317331.1 ENSMUSG00000133360 (from geneSymbol) uc335kzm.1 uc335kzm.1 
ENSMUST00000317334.1 ENSMUSG00000133361 ENSMUST00000317334.1 ENSMUSG00000133361 (from geneSymbol) uc335kzp.1 uc335kzp.1 
ENSMUST00000317348.1 ENSMUSG00000133362 ENSMUST00000317348.1 ENSMUSG00000133362 (from geneSymbol) KY853397 uc335lad.1 uc335lad.1 
ENSMUST00000317350.1 ENSMUSG00000133363 ENSMUST00000317350.1 ENSMUSG00000133363 (from geneSymbol) uc335laf.1 uc335laf.1 
ENSMUST00000317351.1 ENSMUSG00000133364 ENSMUST00000317351.1 ENSMUSG00000133364 (from geneSymbol) uc335lag.1 uc335lag.1 
ENSMUST00000317352.1 ENSMUSG00000133365 ENSMUST00000317352.1 ENSMUSG00000133365 (from geneSymbol) uc335lah.1 uc335lah.1 
ENSMUST00000317366.1 ENSMUSG00000133366 ENSMUST00000317366.1 ENSMUSG00000133366 (from geneSymbol) uc335las.1 uc335las.1 
ENSMUST00000317398.1 ENSMUSG00000133367 ENSMUST00000317398.1 ENSMUSG00000133367 (from geneSymbol) uc335lby.1 uc335lby.1 
ENSMUST00000317400.1 Gm40639 ENSMUST00000317400.1 Gm40639 (from geneSymbol) uc335lca.1 uc335lca.1 
ENSMUST00000317401.1 ENSMUSG00000133368 ENSMUST00000317401.1 ENSMUSG00000133368 (from geneSymbol) uc335lcb.1 uc335lcb.1 
ENSMUST00000317404.1 ENSMUSG00000133369 ENSMUST00000317404.1 ENSMUSG00000133369 (from geneSymbol) uc335lce.1 uc335lce.1 
ENSMUST00000317405.1 ENSMUSG00000133370 ENSMUST00000317405.1 ENSMUSG00000133370 (from geneSymbol) LF200604 uc335lcf.1 uc335lcf.1 
ENSMUST00000317406.1 ENSMUSG00000133371 ENSMUST00000317406.1 ENSMUSG00000133371 (from geneSymbol) uc335lcg.1 uc335lcg.1 
ENSMUST00000317407.1 ENSMUSG00000133372 ENSMUST00000317407.1 ENSMUSG00000133372 (from geneSymbol) uc335lch.1 uc335lch.1 
ENSMUST00000317409.1 Gm12763 ENSMUST00000317409.1 Gm12763 (from geneSymbol) AK030217 uc335lcj.1 uc335lcj.1 
ENSMUST00000317415.1 4930509E16Rik ENSMUST00000317415.1 4930509E16Rik (from geneSymbol) AK015733 uc335lcp.1 uc335lcp.1 
ENSMUST00000317419.1 ENSMUSG00000133373 ENSMUST00000317419.1 ENSMUSG00000133373 (from geneSymbol) uc335lct.1 uc335lct.1 
ENSMUST00000317430.1 ENSMUSG00000133374 ENSMUST00000317430.1 ENSMUSG00000133374 (from geneSymbol) uc335lde.1 uc335lde.1 
ENSMUST00000317432.1 Gm16019 ENSMUST00000317432.1 Gm16019 (from geneSymbol) uc335ldf.1 uc335ldf.1 
ENSMUST00000317439.1 ENSMUSG00000133375 ENSMUST00000317439.1 ENSMUSG00000133375 (from geneSymbol) uc335ldk.1 uc335ldk.1 
ENSMUST00000317444.1 ENSMUSG00000133376 ENSMUST00000317444.1 ENSMUSG00000133376 (from geneSymbol) uc335ldp.1 uc335ldp.1 
ENSMUST00000317446.1 ENSMUSG00000133377 ENSMUST00000317446.1 ENSMUSG00000133377 (from geneSymbol) uc335ldr.1 uc335ldr.1 
ENSMUST00000317447.1 ENSMUSG00000133378 ENSMUST00000317447.1 ENSMUSG00000133378 (from geneSymbol) uc335lds.1 uc335lds.1 
ENSMUST00000317448.1 ENSMUSG00000133379 ENSMUST00000317448.1 ENSMUSG00000133379 (from geneSymbol) uc335ldt.1 uc335ldt.1 
ENSMUST00000317449.1 ENSMUSG00000133380 ENSMUST00000317449.1 ENSMUSG00000133380 (from geneSymbol) uc335ldu.1 uc335ldu.1 
ENSMUST00000317450.1 ENSMUSG00000133381 ENSMUST00000317450.1 ENSMUSG00000133381 (from geneSymbol) uc335ldv.1 uc335ldv.1 
ENSMUST00000317451.1 ENSMUSG00000133382 ENSMUST00000317451.1 ENSMUSG00000133382 (from geneSymbol) uc335ldw.1 uc335ldw.1 
ENSMUST00000317452.1 ENSMUSG00000133383 ENSMUST00000317452.1 ENSMUSG00000133383 (from geneSymbol) uc335ldx.1 uc335ldx.1 
ENSMUST00000317453.1 ENSMUSG00000133384 ENSMUST00000317453.1 ENSMUSG00000133384 (from geneSymbol) uc335ldy.1 uc335ldy.1 
ENSMUST00000317454.1 ENSMUSG00000133385 ENSMUST00000317454.1 ENSMUSG00000133385 (from geneSymbol) uc335ldz.1 uc335ldz.1 
ENSMUST00000317457.1 ENSMUSG00000133386 ENSMUST00000317457.1 ENSMUSG00000133386 (from geneSymbol) uc335lec.1 uc335lec.1 
ENSMUST00000317459.1 Gm30551 ENSMUST00000317459.1 Gm30551 (from geneSymbol) BC099526 uc335lee.1 uc335lee.1 
ENSMUST00000317465.1 ENSMUSG00000133387 ENSMUST00000317465.1 ENSMUSG00000133387 (from geneSymbol) uc335lek.1 uc335lek.1 
ENSMUST00000317493.1 ENSMUSG00000133388 ENSMUST00000317493.1 ENSMUSG00000133388 (from geneSymbol) uc335lfm.1 uc335lfm.1 
ENSMUST00000317496.1 ENSMUSG00000133389 ENSMUST00000317496.1 ENSMUSG00000133389 (from geneSymbol) uc335lfp.1 uc335lfp.1 
ENSMUST00000317497.1 ENSMUSG00000133390 ENSMUST00000317497.1 ENSMUSG00000133390 (from geneSymbol) uc335lfq.1 uc335lfq.1 
ENSMUST00000317499.1 ENSMUSG00000133391 ENSMUST00000317499.1 ENSMUSG00000133391 (from geneSymbol) uc335lfs.1 uc335lfs.1 
ENSMUST00000317511.1 ENSMUSG00000133392 ENSMUST00000317511.1 ENSMUSG00000133392 (from geneSymbol) uc335lge.1 uc335lge.1 
ENSMUST00000317513.1 ENSMUSG00000133393 ENSMUST00000317513.1 ENSMUSG00000133393 (from geneSymbol) uc335lgg.1 uc335lgg.1 
ENSMUST00000317527.1 ENSMUSG00000133394 ENSMUST00000317527.1 ENSMUSG00000133394 (from geneSymbol) uc335lgu.1 uc335lgu.1 
ENSMUST00000317531.1 ENSMUSG00000133395 ENSMUST00000317531.1 ENSMUSG00000133395 (from geneSymbol) uc335lgy.1 uc335lgy.1 
ENSMUST00000317533.1 ENSMUSG00000133396 ENSMUST00000317533.1 ENSMUSG00000133396 (from geneSymbol) uc335lha.1 uc335lha.1 
ENSMUST00000317534.1 ENSMUSG00000133397 ENSMUST00000317534.1 ENSMUSG00000133397 (from geneSymbol) uc335lhb.1 uc335lhb.1 
ENSMUST00000317536.1 Gm2990 ENSMUST00000317536.1 Gm2990 (from geneSymbol) AK049621 uc335lhd.1 uc335lhd.1 
ENSMUST00000317545.1 Gm49417 ENSMUST00000317545.1 Gm49417 (from geneSymbol) AK134715 uc335lhm.1 uc335lhm.1 
ENSMUST00000317566.1 Gm41177 ENSMUST00000317566.1 Gm41177 (from geneSymbol) AK076947 uc335lih.1 uc335lih.1 
ENSMUST00000317596.1 ENSMUSG00000133398 ENSMUST00000317596.1 ENSMUSG00000133398 (from geneSymbol) uc335ljl.1 uc335ljl.1 
ENSMUST00000317597.1 ENSMUSG00000133399 ENSMUST00000317597.1 ENSMUSG00000133399 (from geneSymbol) uc335ljm.1 uc335ljm.1 
ENSMUST00000317631.1 Gm26754 ENSMUST00000317631.1 Gm26754 (from geneSymbol) uc335lku.1 uc335lku.1 
ENSMUST00000317647.1 ENSMUSG00000133400 ENSMUST00000317647.1 ENSMUSG00000133400 (from geneSymbol) uc335llk.1 uc335llk.1 
ENSMUST00000317649.1 ENSMUSG00000133401 ENSMUST00000317649.1 ENSMUSG00000133401 (from geneSymbol) uc335llm.1 uc335llm.1 
ENSMUST00000317654.1 ENSMUSG00000133402 ENSMUST00000317654.1 ENSMUSG00000133402 (from geneSymbol) uc335llr.1 uc335llr.1 
ENSMUST00000317660.1 ENSMUSG00000133403 ENSMUST00000317660.1 ENSMUSG00000133403 (from geneSymbol) uc335llx.1 uc335llx.1 
ENSMUST00000317661.1 ENSMUSG00000133404 ENSMUST00000317661.1 ENSMUSG00000133404 (from geneSymbol) uc335lly.1 uc335lly.1 
ENSMUST00000317664.1 ENSMUSG00000133405 ENSMUST00000317664.1 ENSMUSG00000133405 (from geneSymbol) uc335lmb.1 uc335lmb.1 
ENSMUST00000317666.1 ENSMUSG00000133406 ENSMUST00000317666.1 ENSMUSG00000133406 (from geneSymbol) uc335lmd.1 uc335lmd.1 
ENSMUST00000317667.1 ENSMUSG00000133407 ENSMUST00000317667.1 ENSMUSG00000133407 (from geneSymbol) uc335lme.1 uc335lme.1 
ENSMUST00000317668.1 ENSMUSG00000133408 ENSMUST00000317668.1 ENSMUSG00000133408 (from geneSymbol) uc335lmf.1 uc335lmf.1 
ENSMUST00000317669.1 ENSMUSG00000133409 ENSMUST00000317669.1 ENSMUSG00000133409 (from geneSymbol) uc335lmg.1 uc335lmg.1 
ENSMUST00000317671.1 ENSMUSG00000133410 ENSMUST00000317671.1 ENSMUSG00000133410 (from geneSymbol) uc335lmi.1 uc335lmi.1 
ENSMUST00000317672.1 ENSMUSG00000133411 ENSMUST00000317672.1 ENSMUSG00000133411 (from geneSymbol) uc335lmj.1 uc335lmj.1 
ENSMUST00000317673.1 ENSMUSG00000133412 ENSMUST00000317673.1 ENSMUSG00000133412 (from geneSymbol) uc335lmk.1 uc335lmk.1 
ENSMUST00000317674.1 ENSMUSG00000133413 ENSMUST00000317674.1 ENSMUSG00000133413 (from geneSymbol) uc335lml.1 uc335lml.1 
ENSMUST00000317676.1 Gm33318 ENSMUST00000317676.1 Gm33318 (from geneSymbol) KY468084 uc335lmn.1 uc335lmn.1 
ENSMUST00000317678.1 ENSMUSG00000133414 ENSMUST00000317678.1 ENSMUSG00000133414 (from geneSymbol) uc335lmp.1 uc335lmp.1 
ENSMUST00000317679.1 ENSMUSG00000133415 ENSMUST00000317679.1 ENSMUSG00000133415 (from geneSymbol) uc335lmq.1 uc335lmq.1 
ENSMUST00000317685.1 ENSMUSG00000133416 ENSMUST00000317685.1 ENSMUSG00000133416 (from geneSymbol) uc335lmw.1 uc335lmw.1 
ENSMUST00000317686.1 ENSMUSG00000133417 ENSMUST00000317686.1 ENSMUSG00000133417 (from geneSymbol) uc335lmx.1 uc335lmx.1 
ENSMUST00000317687.1 ENSMUSG00000133418 ENSMUST00000317687.1 ENSMUSG00000133418 (from geneSymbol) uc335lmy.1 uc335lmy.1 
ENSMUST00000317688.1 ENSMUSG00000133419 ENSMUST00000317688.1 ENSMUSG00000133419 (from geneSymbol) uc335lmz.1 uc335lmz.1 
ENSMUST00000317689.1 ENSMUSG00000133420 ENSMUST00000317689.1 ENSMUSG00000133420 (from geneSymbol) uc335lna.1 uc335lna.1 
ENSMUST00000317691.1 ENSMUSG00000133421 ENSMUST00000317691.1 ENSMUSG00000133421 (from geneSymbol) uc335lnc.1 uc335lnc.1 
ENSMUST00000317692.1 ENSMUSG00000133422 ENSMUST00000317692.1 ENSMUSG00000133422 (from geneSymbol) uc335lnd.1 uc335lnd.1 
ENSMUST00000317694.1 ENSMUSG00000133423 ENSMUST00000317694.1 ENSMUSG00000133423 (from geneSymbol) uc335lnf.1 uc335lnf.1 
ENSMUST00000317699.1 ENSMUSG00000133424 ENSMUST00000317699.1 ENSMUSG00000133424 (from geneSymbol) uc335lnk.1 uc335lnk.1 
ENSMUST00000317700.1 ENSMUSG00000133425 ENSMUST00000317700.1 ENSMUSG00000133425 (from geneSymbol) uc335lnl.1 uc335lnl.1 
ENSMUST00000317717.1 ENSMUSG00000133426 ENSMUST00000317717.1 ENSMUSG00000133426 (from geneSymbol) uc335loc.1 uc335loc.1 
ENSMUST00000317719.1 ENSMUSG00000133427 ENSMUST00000317719.1 ENSMUSG00000133427 (from geneSymbol) uc335loe.1 uc335loe.1 
ENSMUST00000317721.1 ENSMUSG00000133428 ENSMUST00000317721.1 ENSMUSG00000133428 (from geneSymbol) uc335log.1 uc335log.1 
ENSMUST00000317729.1 4921515G04Rik ENSMUST00000317729.1 4921515G04Rik (from geneSymbol) AK014899 uc335lol.1 uc335lol.1 
ENSMUST00000317735.1 ENSMUSG00000133430 ENSMUST00000317735.1 ENSMUSG00000133430 (from geneSymbol) uc335lor.1 uc335lor.1 
ENSMUST00000317736.1 Gm16343 ENSMUST00000317736.1 Gm16343 (from geneSymbol) KY468231 uc335los.1 uc335los.1 
ENSMUST00000317738.1 ENSMUSG00000133431 ENSMUST00000317738.1 ENSMUSG00000133431 (from geneSymbol) uc335lou.1 uc335lou.1 
ENSMUST00000317739.1 ENSMUSG00000133432 ENSMUST00000317739.1 ENSMUSG00000133432 (from geneSymbol) uc335lov.1 uc335lov.1 
ENSMUST00000317741.1 ENSMUSG00000133433 ENSMUST00000317741.1 ENSMUSG00000133433 (from geneSymbol) uc335lox.1 uc335lox.1 
ENSMUST00000317742.1 Gm30092 ENSMUST00000317742.1 Gm30092 (from geneSymbol) uc335loy.1 uc335loy.1 
ENSMUST00000317761.1 ENSMUSG00000133434 ENSMUST00000317761.1 ENSMUSG00000133434 (from geneSymbol) uc335lpr.1 uc335lpr.1 
ENSMUST00000317770.1 ENSMUSG00000133435 ENSMUST00000317770.1 ENSMUSG00000133435 (from geneSymbol) uc335lqa.1 uc335lqa.1 
ENSMUST00000317788.1 Gm31373 ENSMUST00000317788.1 Gm31373 (from geneSymbol) uc335lqs.1 uc335lqs.1 
ENSMUST00000317799.1 Gm33609 ENSMUST00000317799.1 Gm33609 (from geneSymbol) AK040435 uc335lrd.1 uc335lrd.1 
ENSMUST00000317844.1 Gm30008 ENSMUST00000317844.1 Gm30008 (from geneSymbol) uc335lsw.1 uc335lsw.1 
ENSMUST00000317856.1 ENSMUSG00000133436 ENSMUST00000317856.1 ENSMUSG00000133436 (from geneSymbol) uc335lti.1 uc335lti.1 
ENSMUST00000317858.1 Gm32369 ENSMUST00000317858.1 Gm32369 (from geneSymbol) uc335ltk.1 uc335ltk.1 
ENSMUST00000317862.1 ENSMUSG00000133437 ENSMUST00000317862.1 ENSMUSG00000133437 (from geneSymbol) uc335lto.1 uc335lto.1 
ENSMUST00000317871.1 Gm31763 ENSMUST00000317871.1 Gm31763 (from geneSymbol) AK079018 uc335ltx.1 uc335ltx.1 
ENSMUST00000317879.1 Gm40988 ENSMUST00000317879.1 Gm40988 (from geneSymbol) uc335luf.1 uc335luf.1 
ENSMUST00000317899.1 Gm49032 ENSMUST00000317899.1 Gm49032 (from geneSymbol) uc335luz.1 uc335luz.1 
ENSMUST00000317909.1 Gm44096 ENSMUST00000317909.1 Gm44096 (from geneSymbol) uc335lvj.1 uc335lvj.1 
ENSMUST00000317912.1 ENSMUSG00000133438 ENSMUST00000317912.1 ENSMUSG00000133438 (from geneSymbol) uc335lvm.1 uc335lvm.1 
ENSMUST00000317913.1 ENSMUSG00000133439 ENSMUST00000317913.1 ENSMUSG00000133439 (from geneSymbol) uc335lvn.1 uc335lvn.1 
ENSMUST00000317914.1 ENSMUSG00000133440 ENSMUST00000317914.1 ENSMUSG00000133440 (from geneSymbol) uc335lvo.1 uc335lvo.1 
ENSMUST00000317915.1 Gm51792 ENSMUST00000317915.1 Gm51792 (from geneSymbol) uc335lvp.1 uc335lvp.1 
ENSMUST00000317916.1 ENSMUSG00000133442 ENSMUST00000317916.1 ENSMUSG00000133442 (from geneSymbol) uc335lvq.1 uc335lvq.1 
ENSMUST00000317920.1 ENSMUSG00000133443 ENSMUST00000317920.1 ENSMUSG00000133443 (from geneSymbol) uc335lvu.1 uc335lvu.1 
ENSMUST00000317922.1 ENSMUSG00000133444 ENSMUST00000317922.1 ENSMUSG00000133444 (from geneSymbol) uc335lvw.1 uc335lvw.1 
ENSMUST00000317924.1 ENSMUSG00000133445 ENSMUST00000317924.1 ENSMUSG00000133445 (from geneSymbol) uc335lvy.1 uc335lvy.1 
ENSMUST00000317925.1 ENSMUSG00000133446 ENSMUST00000317925.1 ENSMUSG00000133446 (from geneSymbol) uc335lvz.1 uc335lvz.1 
ENSMUST00000317926.1 ENSMUSG00000133447 ENSMUST00000317926.1 ENSMUSG00000133447 (from geneSymbol) uc335lwa.1 uc335lwa.1 
ENSMUST00000317927.1 D6Ertd474e ENSMUST00000317927.1 D6Ertd474e (from geneSymbol) AK139687 uc335lwb.1 uc335lwb.1 
ENSMUST00000317935.1 ENSMUSG00000133448 ENSMUST00000317935.1 ENSMUSG00000133448 (from geneSymbol) uc335lwj.1 uc335lwj.1 
ENSMUST00000317940.1 Gm11650 ENSMUST00000317940.1 Gm11650 (from geneSymbol) AK048292 uc335lwo.1 uc335lwo.1 
ENSMUST00000317945.1 ENSMUSG00000133449 ENSMUST00000317945.1 ENSMUSG00000133449 (from geneSymbol) uc335lwt.1 uc335lwt.1 
ENSMUST00000317946.1 ENSMUSG00000133450 ENSMUST00000317946.1 ENSMUSG00000133450 (from geneSymbol) uc335lwu.1 uc335lwu.1 
ENSMUST00000317957.1 ENSMUSG00000133451 ENSMUST00000317957.1 ENSMUSG00000133451 (from geneSymbol) uc335lxa.1 uc335lxa.1 
ENSMUST00000317958.1 ENSMUSG00000133452 ENSMUST00000317958.1 ENSMUSG00000133452 (from geneSymbol) uc335lxb.1 uc335lxb.1 
ENSMUST00000317959.1 ENSMUSG00000133453 ENSMUST00000317959.1 ENSMUSG00000133453 (from geneSymbol) uc335lxc.1 uc335lxc.1 
ENSMUST00000317960.1 ENSMUSG00000133454 ENSMUST00000317960.1 ENSMUSG00000133454 (from geneSymbol) uc335lxd.1 uc335lxd.1 
ENSMUST00000317962.1 ENSMUSG00000133455 ENSMUST00000317962.1 ENSMUSG00000133455 (from geneSymbol) uc335lxf.1 uc335lxf.1 
ENSMUST00000317963.1 ENSMUSG00000133456 ENSMUST00000317963.1 ENSMUSG00000133456 (from geneSymbol) uc335lxg.1 uc335lxg.1 
ENSMUST00000317965.1 ENSMUSG00000133457 ENSMUST00000317965.1 ENSMUSG00000133457 (from geneSymbol) uc335lxi.1 uc335lxi.1 
ENSMUST00000317966.1 Gm39121 ENSMUST00000317966.1 Gm39121 (from geneSymbol) uc335lxj.1 uc335lxj.1 
ENSMUST00000317973.1 ENSMUSG00000133459 ENSMUST00000317973.1 ENSMUSG00000133459 (from geneSymbol) uc335lxo.1 uc335lxo.1 
ENSMUST00000317975.1 ENSMUSG00000133460 ENSMUST00000317975.1 ENSMUSG00000133460 (from geneSymbol) uc335lxq.1 uc335lxq.1 
ENSMUST00000317976.1 ENSMUSG00000133461 ENSMUST00000317976.1 ENSMUSG00000133461 (from geneSymbol) uc335lxr.1 uc335lxr.1 
ENSMUST00000317980.1 Gm29571 ENSMUST00000317980.1 Gm29571 (from geneSymbol) AK050149 uc335lxv.1 uc335lxv.1 
ENSMUST00000318084.1 ENSMUSG00000133462 ENSMUST00000318084.1 ENSMUSG00000133462 (from geneSymbol) uc335mbv.1 uc335mbv.1 
ENSMUST00000318085.1 ENSMUSG00000133463 ENSMUST00000318085.1 ENSMUSG00000133463 (from geneSymbol) uc335mbw.1 uc335mbw.1 
ENSMUST00000318090.1 ENSMUSG00000133464 ENSMUST00000318090.1 ENSMUSG00000133464 (from geneSymbol) uc335mcb.1 uc335mcb.1 
ENSMUST00000318102.1 Gm56788 ENSMUST00000318102.1 Gm56788 (from geneSymbol) uc335mcn.1 uc335mcn.1 
ENSMUST00000318117.1 ENSMUSG00000133465 ENSMUST00000318117.1 ENSMUSG00000133465 (from geneSymbol) uc335mdc.1 uc335mdc.1 
ENSMUST00000318119.1 ENSMUSG00000133466 ENSMUST00000318119.1 ENSMUSG00000133466 (from geneSymbol) uc335mde.1 uc335mde.1 
ENSMUST00000318128.1 ENSMUSG00000133467 ENSMUST00000318128.1 ENSMUSG00000133467 (from geneSymbol) uc335mdn.1 uc335mdn.1 
ENSMUST00000318130.1 ENSMUSG00000133468 ENSMUST00000318130.1 ENSMUSG00000133468 (from geneSymbol) uc335mdp.1 uc335mdp.1 
ENSMUST00000318135.1 ENSMUSG00000133469 ENSMUST00000318135.1 ENSMUSG00000133469 (from geneSymbol) uc335mdu.1 uc335mdu.1 
ENSMUST00000318136.1 ENSMUSG00000133470 ENSMUST00000318136.1 ENSMUSG00000133470 (from geneSymbol) uc335mdv.1 uc335mdv.1 
ENSMUST00000318137.1 ENSMUSG00000133471 ENSMUST00000318137.1 ENSMUSG00000133471 (from geneSymbol) uc335mdw.1 uc335mdw.1 
ENSMUST00000318145.1 ENSMUSG00000133472 ENSMUST00000318145.1 ENSMUSG00000133472 (from geneSymbol) KY467916 uc335mee.1 uc335mee.1 
ENSMUST00000318147.1 ENSMUSG00000133473 ENSMUST00000318147.1 ENSMUSG00000133473 (from geneSymbol) uc335meg.1 uc335meg.1 
ENSMUST00000318148.1 ENSMUSG00000133474 ENSMUST00000318148.1 ENSMUSG00000133474 (from geneSymbol) uc335meh.1 uc335meh.1 
ENSMUST00000318149.1 ENSMUSG00000133475 ENSMUST00000318149.1 ENSMUSG00000133475 (from geneSymbol) uc335mei.1 uc335mei.1 
ENSMUST00000318160.1 Gm40987 ENSMUST00000318160.1 Gm40987 (from geneSymbol) uc335mes.1 uc335mes.1 
ENSMUST00000318169.1 ENSMUSG00000133476 ENSMUST00000318169.1 ENSMUSG00000133476 (from geneSymbol) uc335mfb.1 uc335mfb.1 
ENSMUST00000318177.1 ENSMUSG00000133477 ENSMUST00000318177.1 ENSMUSG00000133477 (from geneSymbol) uc335mfj.1 uc335mfj.1 
ENSMUST00000318178.1 ENSMUSG00000133478 ENSMUST00000318178.1 ENSMUSG00000133478 (from geneSymbol) uc335mfk.1 uc335mfk.1 
ENSMUST00000318184.1 ENSMUSG00000133479 ENSMUST00000318184.1 ENSMUSG00000133479 (from geneSymbol) uc335mfq.1 uc335mfq.1 
ENSMUST00000318185.1 ENSMUSG00000133480 ENSMUST00000318185.1 ENSMUSG00000133480 (from geneSymbol) uc335mfr.1 uc335mfr.1 
ENSMUST00000318186.1 ENSMUSG00000133481 ENSMUST00000318186.1 ENSMUSG00000133481 (from geneSymbol) uc335mfs.1 uc335mfs.1 
ENSMUST00000318188.1 ENSMUSG00000133482 ENSMUST00000318188.1 ENSMUSG00000133482 (from geneSymbol) uc335mfu.1 uc335mfu.1 
ENSMUST00000318194.1 Gm13962 ENSMUST00000318194.1 Gm13962 (from geneSymbol) uc335mga.1 uc335mga.1 
ENSMUST00000318195.1 ENSMUSG00000133483 ENSMUST00000318195.1 ENSMUSG00000133483 (from geneSymbol) uc335mgb.1 uc335mgb.1 
ENSMUST00000318198.1 1700063H06Rik ENSMUST00000318198.1 1700063H06Rik (from geneSymbol) AK006870 uc335mgd.1 uc335mgd.1 
ENSMUST00000318202.1 ENSMUSG00000133484 ENSMUST00000318202.1 ENSMUSG00000133484 (from geneSymbol) uc335mgh.1 uc335mgh.1 
ENSMUST00000318204.1 ENSMUSG00000133485 ENSMUST00000318204.1 ENSMUSG00000133485 (from geneSymbol) AK079763 uc335mgj.1 uc335mgj.1 
ENSMUST00000318212.1 ENSMUSG00000133486 ENSMUST00000318212.1 ENSMUSG00000133486 (from geneSymbol) AK019572 uc335mgr.1 uc335mgr.1 
ENSMUST00000318224.1 ENSMUSG00000133488 ENSMUST00000318224.1 ENSMUSG00000133488 (from geneSymbol) uc335mhc.1 uc335mhc.1 
ENSMUST00000318227.1 ENSMUSG00000133489 ENSMUST00000318227.1 ENSMUSG00000133489 (from geneSymbol) uc335mhf.1 uc335mhf.1 
ENSMUST00000318228.1 ENSMUSG00000133490 ENSMUST00000318228.1 ENSMUSG00000133490 (from geneSymbol) uc335mhg.1 uc335mhg.1 
ENSMUST00000318230.1 ENSMUSG00000133491 ENSMUST00000318230.1 ENSMUSG00000133491 (from geneSymbol) uc335mhi.1 uc335mhi.1 
ENSMUST00000318233.1 Gm56527 ENSMUST00000318233.1 Gm56527 (from geneSymbol) uc335mhl.1 uc335mhl.1 
ENSMUST00000318242.1 ENSMUSG00000133493 ENSMUST00000318242.1 ENSMUSG00000133493 (from geneSymbol) uc335mhu.1 uc335mhu.1 
ENSMUST00000318246.1 Gm42450 ENSMUST00000318246.1 Gm42450 (from geneSymbol) AK039125 uc335mhy.1 uc335mhy.1 
ENSMUST00000318252.1 ENSMUSG00000133494 ENSMUST00000318252.1 ENSMUSG00000133494 (from geneSymbol) uc335mie.1 uc335mie.1 
ENSMUST00000318254.1 ENSMUSG00000133495 ENSMUST00000318254.1 ENSMUSG00000133495 (from geneSymbol) uc335mig.1 uc335mig.1 
ENSMUST00000318256.1 ENSMUSG00000133496 ENSMUST00000318256.1 ENSMUSG00000133496 (from geneSymbol) uc335mii.1 uc335mii.1 
ENSMUST00000318265.1 4933405D12Rik ENSMUST00000318265.1 4933405D12Rik (from geneSymbol) AK045097 uc335mir.1 uc335mir.1 
ENSMUST00000318297.1 ENSMUSG00000133497 ENSMUST00000318297.1 ENSMUSG00000133497 (from geneSymbol) uc335mjx.1 uc335mjx.1 
ENSMUST00000318298.1 ENSMUSG00000133498 ENSMUST00000318298.1 ENSMUSG00000133498 (from geneSymbol) uc335mjy.1 uc335mjy.1 
ENSMUST00000318299.1 Gm16759 ENSMUST00000318299.1 Gm16759 (from geneSymbol) KY652933 uc335mjz.1 uc335mjz.1 
ENSMUST00000318303.1 ENSMUSG00000133499 ENSMUST00000318303.1 ENSMUSG00000133499 (from geneSymbol) uc335mkd.1 uc335mkd.1 
ENSMUST00000318304.1 ENSMUSG00000133500 ENSMUST00000318304.1 ENSMUSG00000133500 (from geneSymbol) uc335mke.1 uc335mke.1 
ENSMUST00000318305.1 ENSMUSG00000133501 ENSMUST00000318305.1 ENSMUSG00000133501 (from geneSymbol) uc335mkf.1 uc335mkf.1 
ENSMUST00000318337.1 4930502A04Rik ENSMUST00000318337.1 4930502A04Rik (from geneSymbol) uc335mll.1 uc335mll.1 
ENSMUST00000318340.1 ENSMUSG00000133502 ENSMUST00000318340.1 ENSMUSG00000133502 (from geneSymbol) uc335mlo.1 uc335mlo.1 
ENSMUST00000318347.1 Gm36543 ENSMUST00000318347.1 Gm36543 (from geneSymbol) uc335mlv.1 uc335mlv.1 
ENSMUST00000318352.1 ENSMUSG00000133503 ENSMUST00000318352.1 ENSMUSG00000133503 (from geneSymbol) uc335mma.1 uc335mma.1 
ENSMUST00000318354.1 ENSMUSG00000133504 ENSMUST00000318354.1 ENSMUSG00000133504 (from geneSymbol) DQ694443 uc335mmc.1 uc335mmc.1 
ENSMUST00000318355.1 ENSMUSG00000133505 ENSMUST00000318355.1 ENSMUSG00000133505 (from geneSymbol) uc335mmd.1 uc335mmd.1 
ENSMUST00000318356.1 ENSMUSG00000133506 ENSMUST00000318356.1 ENSMUSG00000133506 (from geneSymbol) uc335mme.1 uc335mme.1 
ENSMUST00000318358.1 4930429P21Rik ENSMUST00000318358.1 4930429P21Rik (from geneSymbol) AK015246 uc335mmg.1 uc335mmg.1 
ENSMUST00000318361.1 Gm56551 ENSMUST00000318361.1 Gm56551 (from geneSymbol) uc335mmj.1 uc335mmj.1 
ENSMUST00000318365.1 ENSMUSG00000133507 ENSMUST00000318365.1 ENSMUSG00000133507 (from geneSymbol) uc335mmm.1 uc335mmm.1 
ENSMUST00000318377.1 ENSMUSG00000133508 ENSMUST00000318377.1 ENSMUSG00000133508 (from geneSymbol) uc335mmy.1 uc335mmy.1 
ENSMUST00000318378.1 ENSMUSG00000133509 ENSMUST00000318378.1 ENSMUSG00000133509 (from geneSymbol) uc335mmz.1 uc335mmz.1 
ENSMUST00000318382.1 ENSMUSG00000133510 ENSMUST00000318382.1 ENSMUSG00000133510 (from geneSymbol) uc335mnd.1 uc335mnd.1 
ENSMUST00000318385.1 Gm33115 ENSMUST00000318385.1 Gm33115 (from geneSymbol) BC049687 uc335mng.1 uc335mng.1 
ENSMUST00000318390.1 ENSMUSG00000133511 ENSMUST00000318390.1 ENSMUSG00000133511 (from geneSymbol) uc335mnl.1 uc335mnl.1 
ENSMUST00000318392.1 ENSMUSG00000133512 ENSMUST00000318392.1 ENSMUSG00000133512 (from geneSymbol) uc335mnn.1 uc335mnn.1 
ENSMUST00000318393.1 ENSMUSG00000133513 ENSMUST00000318393.1 ENSMUSG00000133513 (from geneSymbol) uc335mno.1 uc335mno.1 
ENSMUST00000318395.1 ENSMUSG00000133514 ENSMUST00000318395.1 ENSMUSG00000133514 (from geneSymbol) uc335mnq.1 uc335mnq.1 
ENSMUST00000318396.1 ENSMUSG00000133515 ENSMUST00000318396.1 ENSMUSG00000133515 (from geneSymbol) uc335mnr.1 uc335mnr.1 
ENSMUST00000318397.1 ENSMUSG00000133516 ENSMUST00000318397.1 ENSMUSG00000133516 (from geneSymbol) uc335mns.1 uc335mns.1 
ENSMUST00000318399.1 ENSMUSG00000133517 ENSMUST00000318399.1 ENSMUSG00000133517 (from geneSymbol) uc335mnu.1 uc335mnu.1 
ENSMUST00000318401.1 ENSMUSG00000133518 ENSMUST00000318401.1 ENSMUSG00000133518 (from geneSymbol) uc335mnw.1 uc335mnw.1 
ENSMUST00000318402.1 ENSMUSG00000133519 ENSMUST00000318402.1 ENSMUSG00000133519 (from geneSymbol) uc335mnx.1 uc335mnx.1 
ENSMUST00000318404.1 ENSMUSG00000133520 ENSMUST00000318404.1 ENSMUSG00000133520 (from geneSymbol) uc335mnz.1 uc335mnz.1 
ENSMUST00000318406.1 Gm35548 ENSMUST00000318406.1 Gm35548 (from geneSymbol) uc335mob.1 uc335mob.1 
ENSMUST00000318440.1 ENSMUSG00000133521 ENSMUST00000318440.1 ENSMUSG00000133521 (from geneSymbol) uc335mpj.1 uc335mpj.1 
ENSMUST00000318441.1 ENSMUSG00000133522 ENSMUST00000318441.1 ENSMUSG00000133522 (from geneSymbol) uc335mpk.1 uc335mpk.1 
ENSMUST00000318442.1 ENSMUSG00000133523 ENSMUST00000318442.1 ENSMUSG00000133523 (from geneSymbol) uc335mpl.1 uc335mpl.1 
ENSMUST00000318444.1 ENSMUSG00000133524 ENSMUST00000318444.1 ENSMUSG00000133524 (from geneSymbol) uc335mpn.1 uc335mpn.1 
ENSMUST00000318445.1 ENSMUSG00000133525 ENSMUST00000318445.1 ENSMUSG00000133525 (from geneSymbol) uc335mpo.1 uc335mpo.1 
ENSMUST00000318448.1 ENSMUSG00000133526 ENSMUST00000318448.1 ENSMUSG00000133526 (from geneSymbol) uc335mpr.1 uc335mpr.1 
ENSMUST00000318451.1 ENSMUSG00000133527 ENSMUST00000318451.1 ENSMUSG00000133527 (from geneSymbol) uc335mpu.1 uc335mpu.1 
ENSMUST00000318456.1 Gm17733 ENSMUST00000318456.1 Gm17733 (from geneSymbol) AK038749 uc335mpz.1 uc335mpz.1 
ENSMUST00000318461.1 Gm26868 ENSMUST00000318461.1 Gm26868 (from geneSymbol) BC082591 uc335mqe.1 uc335mqe.1 
ENSMUST00000318471.1 ENSMUSG00000133528 ENSMUST00000318471.1 ENSMUSG00000133528 (from geneSymbol) uc335mqo.1 uc335mqo.1 
ENSMUST00000318474.1 Gm16015 ENSMUST00000318474.1 Gm16015 (from geneSymbol) uc335mqr.1 uc335mqr.1 
ENSMUST00000318499.1 ENSMUSG00000133529 ENSMUST00000318499.1 ENSMUSG00000133529 (from geneSymbol) uc335mrq.1 uc335mrq.1 
ENSMUST00000318501.1 ENSMUSG00000133530 ENSMUST00000318501.1 ENSMUSG00000133530 (from geneSymbol) uc335mrs.1 uc335mrs.1 
ENSMUST00000318502.1 Gm1976 ENSMUST00000318502.1 Gm1976 (from geneSymbol) AK137318 uc335mrt.1 uc335mrt.1 
ENSMUST00000318582.1 Gm45589 ENSMUST00000318582.1 Gm45589 (from geneSymbol) uc335muv.1 uc335muv.1 
ENSMUST00000318603.1 ENSMUSG00000133531 ENSMUST00000318603.1 ENSMUSG00000133531 (from geneSymbol) uc335mvq.1 uc335mvq.1 
ENSMUST00000318605.1 ENSMUSG00000133532 ENSMUST00000318605.1 ENSMUSG00000133532 (from geneSymbol) uc335mvs.1 uc335mvs.1 
ENSMUST00000318606.1 ENSMUSG00000133533 ENSMUST00000318606.1 ENSMUSG00000133533 (from geneSymbol) uc335mvt.1 uc335mvt.1 
ENSMUST00000318610.1 ENSMUSG00000133534 ENSMUST00000318610.1 ENSMUSG00000133534 (from geneSymbol) uc335mvx.1 uc335mvx.1 
ENSMUST00000318612.1 ENSMUSG00000133535 ENSMUST00000318612.1 ENSMUSG00000133535 (from geneSymbol) uc335mvz.1 uc335mvz.1 
ENSMUST00000318613.1 Gm53660 ENSMUST00000318613.1 Gm53660 (from geneSymbol) uc335mwa.1 uc335mwa.1 
ENSMUST00000318643.1 ENSMUSG00000133536 ENSMUST00000318643.1 ENSMUSG00000133536 (from geneSymbol) uc335mxd.1 uc335mxd.1 
ENSMUST00000318644.1 ENSMUSG00000133537 ENSMUST00000318644.1 ENSMUSG00000133537 (from geneSymbol) uc335mxe.1 uc335mxe.1 
ENSMUST00000318646.1 ENSMUSG00000133538 ENSMUST00000318646.1 ENSMUSG00000133538 (from geneSymbol) uc335mxg.1 uc335mxg.1 
ENSMUST00000318657.1 ENSMUSG00000133539 ENSMUST00000318657.1 ENSMUSG00000133539 (from geneSymbol) uc335mxr.1 uc335mxr.1 
ENSMUST00000318659.1 ENSMUSG00000133540 ENSMUST00000318659.1 ENSMUSG00000133540 (from geneSymbol) uc335mxt.1 uc335mxt.1 
ENSMUST00000318660.1 ENSMUSG00000133541 ENSMUST00000318660.1 ENSMUSG00000133541 (from geneSymbol) uc335mxu.1 uc335mxu.1 
ENSMUST00000318664.1 ENSMUSG00000133542 ENSMUST00000318664.1 ENSMUSG00000133542 (from geneSymbol) uc335mxy.1 uc335mxy.1 
ENSMUST00000318665.1 ENSMUSG00000133543 ENSMUST00000318665.1 ENSMUSG00000133543 (from geneSymbol) uc335mxz.1 uc335mxz.1 
ENSMUST00000318666.1 ENSMUSG00000133544 ENSMUST00000318666.1 ENSMUSG00000133544 (from geneSymbol) uc335mya.1 uc335mya.1 
ENSMUST00000318669.1 ENSMUSG00000133545 ENSMUST00000318669.1 ENSMUSG00000133545 (from geneSymbol) uc335myd.1 uc335myd.1 
ENSMUST00000318671.1 ENSMUSG00000133546 ENSMUST00000318671.1 ENSMUSG00000133546 (from geneSymbol) uc335myf.1 uc335myf.1 
ENSMUST00000318673.1 ENSMUSG00000133547 ENSMUST00000318673.1 ENSMUSG00000133547 (from geneSymbol) uc335myh.1 uc335myh.1 
ENSMUST00000318675.1 ENSMUSG00000133548 ENSMUST00000318675.1 ENSMUSG00000133548 (from geneSymbol) AK021355 uc335myj.1 uc335myj.1 
ENSMUST00000318681.1 ENSMUSG00000133551 ENSMUST00000318681.1 ENSMUSG00000133551 (from geneSymbol) uc335myk.1 uc335myk.1 
ENSMUST00000318682.1 Gm10782 ENSMUST00000318682.1 Gm10782 (from geneSymbol) AK029453 uc335myl.1 uc335myl.1 
ENSMUST00000318685.1 ENSMUSG00000133552 ENSMUST00000318685.1 ENSMUSG00000133552 (from geneSymbol) uc335myo.1 uc335myo.1 
ENSMUST00000318686.1 ENSMUSG00000133553 ENSMUST00000318686.1 ENSMUSG00000133553 (from geneSymbol) uc335myp.1 uc335myp.1 
ENSMUST00000318689.1 ENSMUSG00000133554 ENSMUST00000318689.1 ENSMUSG00000133554 (from geneSymbol) uc335mys.1 uc335mys.1 
ENSMUST00000318690.1 ENSMUSG00000133555 ENSMUST00000318690.1 ENSMUSG00000133555 (from geneSymbol) uc335myt.1 uc335myt.1 
ENSMUST00000318691.1 ENSMUSG00000133556 ENSMUST00000318691.1 ENSMUSG00000133556 (from geneSymbol) uc335myu.1 uc335myu.1 
ENSMUST00000318694.1 ENSMUSG00000133557 ENSMUST00000318694.1 ENSMUSG00000133557 (from geneSymbol) uc335myx.1 uc335myx.1 
ENSMUST00000318695.1 ENSMUSG00000133558 ENSMUST00000318695.1 ENSMUSG00000133558 (from geneSymbol) uc335myy.1 uc335myy.1 
ENSMUST00000318696.1 ENSMUSG00000133559 ENSMUST00000318696.1 ENSMUSG00000133559 (from geneSymbol) uc335myz.1 uc335myz.1 
ENSMUST00000318700.1 Gm50301 ENSMUST00000318700.1 Gm50301 (from geneSymbol) uc335mzd.1 uc335mzd.1 
ENSMUST00000318701.1 ENSMUSG00000133560 ENSMUST00000318701.1 ENSMUSG00000133560 (from geneSymbol) uc335mze.1 uc335mze.1 
ENSMUST00000318702.1 4930556I23Rik ENSMUST00000318702.1 4930556I23Rik (from geneSymbol) AK016146 uc335mzf.1 uc335mzf.1 
ENSMUST00000318707.1 ENSMUSG00000133561 ENSMUST00000318707.1 ENSMUSG00000133561 (from geneSymbol) uc335mzk.1 uc335mzk.1 
ENSMUST00000318710.1 ENSMUSG00000133562 ENSMUST00000318710.1 ENSMUSG00000133562 (from geneSymbol) uc335mzn.1 uc335mzn.1 
ENSMUST00000318711.1 ENSMUSG00000133563 ENSMUST00000318711.1 ENSMUSG00000133563 (from geneSymbol) uc335mzo.1 uc335mzo.1 
ENSMUST00000318712.1 ENSMUSG00000133564 ENSMUST00000318712.1 ENSMUSG00000133564 (from geneSymbol) uc335mzp.1 uc335mzp.1 
ENSMUST00000318713.1 ENSMUSG00000133565 ENSMUST00000318713.1 ENSMUSG00000133565 (from geneSymbol) uc335mzq.1 uc335mzq.1 
ENSMUST00000318717.1 ENSMUSG00000133566 ENSMUST00000318717.1 ENSMUSG00000133566 (from geneSymbol) uc335mzu.1 uc335mzu.1 
ENSMUST00000318719.1 ENSMUSG00000133567 ENSMUST00000318719.1 ENSMUSG00000133567 (from geneSymbol) uc335mzw.1 uc335mzw.1 
ENSMUST00000318720.1 ENSMUSG00000133568 ENSMUST00000318720.1 ENSMUSG00000133568 (from geneSymbol) uc335mzx.1 uc335mzx.1 
ENSMUST00000318723.1 ENSMUSG00000133569 ENSMUST00000318723.1 ENSMUSG00000133569 (from geneSymbol) uc335naa.1 uc335naa.1 
ENSMUST00000318724.1 ENSMUSG00000133570 ENSMUST00000318724.1 ENSMUSG00000133570 (from geneSymbol) uc335nab.1 uc335nab.1 
ENSMUST00000318726.1 Gm41561 ENSMUST00000318726.1 Gm41561 (from geneSymbol) uc335nad.1 uc335nad.1 
ENSMUST00000318728.1 ENSMUSG00000133571 ENSMUST00000318728.1 ENSMUSG00000133571 (from geneSymbol) uc335naf.1 uc335naf.1 
ENSMUST00000318732.1 Gm33053 ENSMUST00000318732.1 Gm33053 (from geneSymbol) uc335naj.1 uc335naj.1 
ENSMUST00000318759.1 ENSMUSG00000133572 ENSMUST00000318759.1 ENSMUSG00000133572 (from geneSymbol) uc335nbk.1 uc335nbk.1 
ENSMUST00000318760.1 ENSMUSG00000133573 ENSMUST00000318760.1 ENSMUSG00000133573 (from geneSymbol) uc335nbl.1 uc335nbl.1 
ENSMUST00000318761.1 ENSMUSG00000133574 ENSMUST00000318761.1 ENSMUSG00000133574 (from geneSymbol) uc335nbm.1 uc335nbm.1 
ENSMUST00000318765.1 ENSMUSG00000133575 ENSMUST00000318765.1 ENSMUSG00000133575 (from geneSymbol) uc335nbq.1 uc335nbq.1 
ENSMUST00000318766.1 Gm49431 ENSMUST00000318766.1 Gm49431 (from geneSymbol) uc335nbr.1 uc335nbr.1 
ENSMUST00000318782.1 Gm16208 ENSMUST00000318782.1 Gm16208 (from geneSymbol) AK028089 uc335nch.1 uc335nch.1 
ENSMUST00000318789.1 ENSMUSG00000133576 ENSMUST00000318789.1 ENSMUSG00000133576 (from geneSymbol) uc335nco.1 uc335nco.1 
ENSMUST00000318790.1 ENSMUSG00000133577 ENSMUST00000318790.1 ENSMUSG00000133577 (from geneSymbol) uc335ncp.1 uc335ncp.1 
ENSMUST00000318792.1 ENSMUSG00000133578 ENSMUST00000318792.1 ENSMUSG00000133578 (from geneSymbol) uc335ncr.1 uc335ncr.1 
ENSMUST00000318793.1 ENSMUSG00000133579 ENSMUST00000318793.1 ENSMUSG00000133579 (from geneSymbol) uc335ncs.1 uc335ncs.1 
ENSMUST00000318798.1 ENSMUSG00000133580 ENSMUST00000318798.1 ENSMUSG00000133580 (from geneSymbol) uc335ncx.1 uc335ncx.1 
ENSMUST00000318808.1 Jpx ENSMUST00000318808.1 Jpx (from geneSymbol) JN410359 uc335ndg.1 uc335ndg.1 
ENSMUST00000318893.1 ENSMUSG00000133581 ENSMUST00000318893.1 ENSMUSG00000133581 (from geneSymbol) uc335ngn.1 uc335ngn.1 
ENSMUST00000318894.1 Gm41253 ENSMUST00000318894.1 Gm41253 (from geneSymbol) uc335ngo.1 uc335ngo.1 
ENSMUST00000318901.1 ENSMUSG00000133582 ENSMUST00000318901.1 ENSMUSG00000133582 (from geneSymbol) uc335ngv.1 uc335ngv.1 
ENSMUST00000318904.1 ENSMUSG00000133583 ENSMUST00000318904.1 ENSMUSG00000133583 (from geneSymbol) uc335ngy.1 uc335ngy.1 
ENSMUST00000318905.1 ENSMUSG00000133584 ENSMUST00000318905.1 ENSMUSG00000133584 (from geneSymbol) uc335ngz.1 uc335ngz.1 
ENSMUST00000318907.1 ENSMUSG00000133585 ENSMUST00000318907.1 ENSMUSG00000133585 (from geneSymbol) uc335nhb.1 uc335nhb.1 
ENSMUST00000318911.1 ENSMUSG00000133586 ENSMUST00000318911.1 ENSMUSG00000133586 (from geneSymbol) uc335nhf.1 uc335nhf.1 
ENSMUST00000318913.1 ENSMUSG00000133587 ENSMUST00000318913.1 ENSMUSG00000133587 (from geneSymbol) uc335nhh.1 uc335nhh.1 
ENSMUST00000318914.1 ENSMUSG00000133588 ENSMUST00000318914.1 ENSMUSG00000133588 (from geneSymbol) uc335nhi.1 uc335nhi.1 
ENSMUST00000318916.1 ENSMUSG00000133589 ENSMUST00000318916.1 ENSMUSG00000133589 (from geneSymbol) uc335nhk.1 uc335nhk.1 
ENSMUST00000318918.1 ENSMUSG00000133591 ENSMUST00000318918.1 ENSMUSG00000133591 (from geneSymbol) uc335nhl.1 uc335nhl.1 
ENSMUST00000318919.1 ENSMUSG00000133592 ENSMUST00000318919.1 ENSMUSG00000133592 (from geneSymbol) uc335nhm.1 uc335nhm.1 
ENSMUST00000318922.1 ENSMUSG00000133593 ENSMUST00000318922.1 ENSMUSG00000133593 (from geneSymbol) uc335nhp.1 uc335nhp.1 
ENSMUST00000318926.1 ENSMUSG00000133594 ENSMUST00000318926.1 ENSMUSG00000133594 (from geneSymbol) uc335nht.1 uc335nht.1 
ENSMUST00000318938.1 ENSMUSG00000133596 ENSMUST00000318938.1 ENSMUSG00000133596 (from geneSymbol) uc335nie.1 uc335nie.1 
ENSMUST00000318939.1 ENSMUSG00000133597 ENSMUST00000318939.1 ENSMUSG00000133597 (from geneSymbol) uc335nif.1 uc335nif.1 
ENSMUST00000318940.1 ENSMUSG00000133598 ENSMUST00000318940.1 ENSMUSG00000133598 (from geneSymbol) uc335nig.1 uc335nig.1 
ENSMUST00000318944.1 ENSMUSG00000133599 ENSMUST00000318944.1 ENSMUSG00000133599 (from geneSymbol) uc335nik.1 uc335nik.1 
ENSMUST00000318948.1 AV039307 ENSMUST00000318948.1 AV039307 (from geneSymbol) AK006022 uc335nio.1 uc335nio.1 
ENSMUST00000319017.1 ENSMUSG00000133600 ENSMUST00000319017.1 ENSMUSG00000133600 (from geneSymbol) uc335nlf.1 uc335nlf.1 
ENSMUST00000319021.1 ENSMUSG00000133601 ENSMUST00000319021.1 ENSMUSG00000133601 (from geneSymbol) uc335nlj.1 uc335nlj.1 
ENSMUST00000319022.1 4933430N04Rik ENSMUST00000319022.1 4933430N04Rik (from geneSymbol) AK017000 uc335nlk.1 uc335nlk.1 
ENSMUST00000319030.1 ENSMUSG00000133602 ENSMUST00000319030.1 ENSMUSG00000133602 (from geneSymbol) uc335nls.1 uc335nls.1 
ENSMUST00000319031.1 ENSMUSG00000133603 ENSMUST00000319031.1 ENSMUSG00000133603 (from geneSymbol) uc335nlt.1 uc335nlt.1 
ENSMUST00000319033.1 ENSMUSG00000133604 ENSMUST00000319033.1 ENSMUSG00000133604 (from geneSymbol) uc335nlv.1 uc335nlv.1 
ENSMUST00000319076.1 ENSMUSG00000133605 ENSMUST00000319076.1 ENSMUSG00000133605 (from geneSymbol) uc335nnm.1 uc335nnm.1 
ENSMUST00000319077.1 ENSMUSG00000133606 ENSMUST00000319077.1 ENSMUSG00000133606 (from geneSymbol) uc335nnn.1 uc335nnn.1 
ENSMUST00000319148.1 ENSMUSG00000133607 ENSMUST00000319148.1 ENSMUSG00000133607 (from geneSymbol) uc335nqf.1 uc335nqf.1 
ENSMUST00000319150.1 ENSMUSG00000133608 ENSMUST00000319150.1 ENSMUSG00000133608 (from geneSymbol) uc335nqh.1 uc335nqh.1 
ENSMUST00000319151.1 ENSMUSG00000133609 ENSMUST00000319151.1 ENSMUSG00000133609 (from geneSymbol) uc335nqi.1 uc335nqi.1 
ENSMUST00000319152.1 ENSMUSG00000133610 ENSMUST00000319152.1 ENSMUSG00000133610 (from geneSymbol) uc335nqj.1 uc335nqj.1 
ENSMUST00000319155.1 ENSMUSG00000133611 ENSMUST00000319155.1 ENSMUSG00000133611 (from geneSymbol) uc335nqm.1 uc335nqm.1 
ENSMUST00000319158.1 Gm56547 ENSMUST00000319158.1 Gm56547 (from geneSymbol) uc335nqp.1 uc335nqp.1 
ENSMUST00000319173.1 ENSMUSG00000133612 ENSMUST00000319173.1 ENSMUSG00000133612 (from geneSymbol) uc335nre.1 uc335nre.1 
ENSMUST00000319175.1 ENSMUSG00000133613 ENSMUST00000319175.1 ENSMUSG00000133613 (from geneSymbol) uc335nrg.1 uc335nrg.1 
ENSMUST00000319176.1 ENSMUSG00000133614 ENSMUST00000319176.1 ENSMUSG00000133614 (from geneSymbol) uc335nrh.1 uc335nrh.1 
ENSMUST00000319181.1 ENSMUSG00000133615 ENSMUST00000319181.1 ENSMUSG00000133615 (from geneSymbol) uc335nrm.1 uc335nrm.1 
ENSMUST00000319184.1 ENSMUSG00000133616 ENSMUST00000319184.1 ENSMUSG00000133616 (from geneSymbol) uc335nrp.1 uc335nrp.1 
ENSMUST00000319187.1 ENSMUSG00000133617 ENSMUST00000319187.1 ENSMUSG00000133617 (from geneSymbol) uc335nrs.1 uc335nrs.1 
ENSMUST00000319188.1 ENSMUSG00000121764 ENSMUST00000319188.1 ENSMUSG00000121764 (from geneSymbol) AY149175 uc335nrt.1 uc335nrt.1 
ENSMUST00000319196.1 ENSMUSG00000133618 ENSMUST00000319196.1 ENSMUSG00000133618 (from geneSymbol) uc335nsb.1 uc335nsb.1 
ENSMUST00000319199.1 ENSMUSG00000133619 ENSMUST00000319199.1 ENSMUSG00000133619 (from geneSymbol) uc335nse.1 uc335nse.1 
ENSMUST00000319202.1 ENSMUSG00000133620 ENSMUST00000319202.1 ENSMUSG00000133620 (from geneSymbol) uc335nsh.1 uc335nsh.1 
ENSMUST00000319203.1 ENSMUSG00000133621 ENSMUST00000319203.1 ENSMUSG00000133621 (from geneSymbol) uc335nsi.1 uc335nsi.1 
ENSMUST00000319204.1 ENSMUSG00000133622 ENSMUST00000319204.1 ENSMUSG00000133622 (from geneSymbol) uc335nsj.1 uc335nsj.1 
ENSMUST00000319205.1 Spehd ENSMUST00000319205.1 Spehd (from geneSymbol) uc335nsk.1 uc335nsk.1 
ENSMUST00000319222.1 ENSMUSG00000133623 ENSMUST00000319222.1 ENSMUSG00000133623 (from geneSymbol) uc335ntb.1 uc335ntb.1 
ENSMUST00000319224.1 ENSMUSG00000133624 ENSMUST00000319224.1 ENSMUSG00000133624 (from geneSymbol) uc335ntd.1 uc335ntd.1 
ENSMUST00000319229.1 ENSMUSG00000133625 ENSMUST00000319229.1 ENSMUSG00000133625 (from geneSymbol) uc335nti.1 uc335nti.1 
ENSMUST00000319230.1 Gm14204 ENSMUST00000319230.1 predicted gene 14204, transcript variant 2 (from RefSeq NR_040359.1) NR_040359 uc335ntj.1 uc335ntj.1 
ENSMUST00000319254.1 ENSMUSG00000133626 ENSMUST00000319254.1 ENSMUSG00000133626 (from geneSymbol) uc335nuh.1 uc335nuh.1 
ENSMUST00000319274.1 ENSMUSG00000133627 ENSMUST00000319274.1 ENSMUSG00000133627 (from geneSymbol) uc335nvb.1 uc335nvb.1 
ENSMUST00000319279.1 ENSMUSG00000133628 ENSMUST00000319279.1 ENSMUSG00000133628 (from geneSymbol) uc335nvg.1 uc335nvg.1 
ENSMUST00000319280.1 ENSMUSG00000133629 ENSMUST00000319280.1 ENSMUSG00000133629 (from geneSymbol) uc335nvh.1 uc335nvh.1 
ENSMUST00000319288.1 1700061J23Rik ENSMUST00000319288.1 1700061J23Rik (from geneSymbol) AK006857 uc335nvp.1 uc335nvp.1 
ENSMUST00000319319.1 ENSMUSG00000133630 ENSMUST00000319319.1 ENSMUSG00000133630 (from geneSymbol) uc335nwu.1 uc335nwu.1 
ENSMUST00000319320.1 ENSMUSG00000133631 ENSMUST00000319320.1 ENSMUSG00000133631 (from geneSymbol) uc335nwv.1 uc335nwv.1 
ENSMUST00000319321.1 ENSMUSG00000133632 ENSMUST00000319321.1 ENSMUSG00000133632 (from geneSymbol) uc335nww.1 uc335nww.1 
ENSMUST00000319323.1 ENSMUSG00000133633 ENSMUST00000319323.1 ENSMUSG00000133633 (from geneSymbol) AK016100 uc335nwy.1 uc335nwy.1 
ENSMUST00000319357.1 ENSMUSG00000133634 ENSMUST00000319357.1 ENSMUSG00000133634 (from geneSymbol) AK138241 uc335nyg.1 uc335nyg.1 
ENSMUST00000319359.1 ENSMUSG00000133635 ENSMUST00000319359.1 ENSMUSG00000133635 (from geneSymbol) uc335nyi.1 uc335nyi.1 
ENSMUST00000319362.1 Dleu2 ENSMUST00000319362.1 Dleu2 (from geneSymbol) AK165901 uc335nyl.1 uc335nyl.1 
ENSMUST00000319561.1 ENSMUSG00000133636 ENSMUST00000319561.1 ENSMUSG00000133636 (from geneSymbol) uc335oga.1 uc335oga.1 
ENSMUST00000319562.1 ENSMUSG00000133637 ENSMUST00000319562.1 ENSMUSG00000133637 (from geneSymbol) uc335ogb.1 uc335ogb.1 
ENSMUST00000319563.1 Gm15283 ENSMUST00000319563.1 Gm15283 (from geneSymbol) AK048798 uc335ogc.1 uc335ogc.1 
ENSMUST00000319578.1 ENSMUSG00000133638 ENSMUST00000319578.1 ENSMUSG00000133638 (from geneSymbol) uc335ogr.1 uc335ogr.1 
ENSMUST00000319582.1 ENSMUSG00000133640 ENSMUST00000319582.1 ENSMUSG00000133640 (from geneSymbol) uc335ogu.1 uc335ogu.1 
ENSMUST00000319642.1 Gm6980 ENSMUST00000319642.1 Gm6980 (from geneSymbol) AK086943 uc335ojb.1 uc335ojb.1 
ENSMUST00000319656.1 ENSMUSG00000133641 ENSMUST00000319656.1 ENSMUSG00000133641 (from geneSymbol) uc335ojp.1 uc335ojp.1 
ENSMUST00000319657.1 AA387883 ENSMUST00000319657.1 AA387883 (from geneSymbol) AK043996 uc335ojq.1 uc335ojq.1 
ENSMUST00000319661.1 ENSMUSG00000133642 ENSMUST00000319661.1 ENSMUSG00000133642 (from geneSymbol) uc335oju.1 uc335oju.1 
ENSMUST00000319662.1 ENSMUSG00000133643 ENSMUST00000319662.1 ENSMUSG00000133643 (from geneSymbol) uc335ojv.1 uc335ojv.1 
ENSMUST00000319663.1 ENSMUSG00000133644 ENSMUST00000319663.1 ENSMUSG00000133644 (from geneSymbol) uc335ojw.1 uc335ojw.1 
ENSMUST00000319664.1 ENSMUSG00000133645 ENSMUST00000319664.1 ENSMUSG00000133645 (from geneSymbol) uc335ojx.1 uc335ojx.1 
ENSMUST00000319665.1 ENSMUSG00000133646 ENSMUST00000319665.1 ENSMUSG00000133646 (from geneSymbol) uc335ojy.1 uc335ojy.1 
ENSMUST00000319668.1 ENSMUSG00000133647 ENSMUST00000319668.1 ENSMUSG00000133647 (from geneSymbol) uc335okb.1 uc335okb.1 
ENSMUST00000319670.1 1700020G17Rik ENSMUST00000319670.1 1700020G17Rik (from geneSymbol) AK006160 uc335okd.1 uc335okd.1 
ENSMUST00000319702.1 ENSMUSG00000133648 ENSMUST00000319702.1 ENSMUSG00000133648 (from geneSymbol) uc335olj.1 uc335olj.1 
ENSMUST00000319728.1 ENSMUSG00000133649 ENSMUST00000319728.1 ENSMUSG00000133649 (from geneSymbol) uc335omj.1 uc335omj.1 
ENSMUST00000319732.1 ENSMUSG00000133650 ENSMUST00000319732.1 ENSMUSG00000133650 (from geneSymbol) uc335omn.1 uc335omn.1 
ENSMUST00000319743.1 ENSMUSG00000133651 ENSMUST00000319743.1 ENSMUSG00000133651 (from geneSymbol) uc335omy.1 uc335omy.1 
ENSMUST00000319745.1 Ftx ENSMUST00000319745.1 Ftx (from geneSymbol) AK085125 uc335ona.1 uc335ona.1 
ENSMUST00000319809.1 ENSMUSG00000133653 ENSMUST00000319809.1 ENSMUSG00000133653 (from geneSymbol) uc335oph.1 uc335oph.1 
ENSMUST00000319811.1 ENSMUSG00000133654 ENSMUST00000319811.1 ENSMUSG00000133654 (from geneSymbol) uc335opj.1 uc335opj.1 
ENSMUST00000319819.1 ENSMUSG00000133655 ENSMUST00000319819.1 ENSMUSG00000133655 (from geneSymbol) uc335opr.1 uc335opr.1 
ENSMUST00000319823.1 ENSMUSG00000133656 ENSMUST00000319823.1 ENSMUSG00000133656 (from geneSymbol) uc335opv.1 uc335opv.1 
ENSMUST00000319824.1 ENSMUSG00000133657 ENSMUST00000319824.1 ENSMUSG00000133657 (from geneSymbol) AK082760 uc335opw.1 uc335opw.1 
ENSMUST00000319829.1 ENSMUSG00000133658 ENSMUST00000319829.1 ENSMUSG00000133658 (from geneSymbol) uc335oqb.1 uc335oqb.1 
ENSMUST00000319830.1 ENSMUSG00000133659 ENSMUST00000319830.1 ENSMUSG00000133659 (from geneSymbol) uc335oqc.1 uc335oqc.1 
ENSMUST00000319848.1 ENSMUSG00000121507 ENSMUST00000319848.1 ENSMUSG00000121507 (from geneSymbol) BC059104 uc335oqu.1 uc335oqu.1 
ENSMUST00000319872.1 Gm56927 ENSMUST00000319872.1 Gm56927 (from geneSymbol) uc335orq.1 uc335orq.1 
ENSMUST00000319935.1 ENSMUSG00000133660 ENSMUST00000319935.1 ENSMUSG00000133660 (from geneSymbol) uc335otn.1 uc335otn.1 
ENSMUST00000319936.1 ENSMUSG00000133661 ENSMUST00000319936.1 ENSMUSG00000133661 (from geneSymbol) uc335oto.1 uc335oto.1 
ENSMUST00000319937.1 ENSMUSG00000133662 ENSMUST00000319937.1 ENSMUSG00000133662 (from geneSymbol) uc335otp.1 uc335otp.1 
ENSMUST00000319939.1 ENSMUSG00000133663 ENSMUST00000319939.1 ENSMUSG00000133663 (from geneSymbol) uc335otr.1 uc335otr.1 
ENSMUST00000319941.1 ENSMUSG00000133664 ENSMUST00000319941.1 ENSMUSG00000133664 (from geneSymbol) DQ549127 uc335ott.1 uc335ott.1 
ENSMUST00000319942.1 ENSMUSG00000133665 ENSMUST00000319942.1 ENSMUSG00000133665 (from geneSymbol) uc335otu.1 uc335otu.1 
ENSMUST00000319944.1 ENSMUSG00000133666 ENSMUST00000319944.1 ENSMUSG00000133666 (from geneSymbol) uc335otw.1 uc335otw.1 
ENSMUST00000319946.1 ENSMUSG00000133667 ENSMUST00000319946.1 ENSMUSG00000133667 (from geneSymbol) uc335oty.1 uc335oty.1 
ENSMUST00000319948.1 A230006K03Rik ENSMUST00000319948.1 A230006K03Rik (from geneSymbol) DQ656357 uc335oua.1 uc335oua.1 
ENSMUST00000319968.1 ENSMUSG00000133668 ENSMUST00000319968.1 ENSMUSG00000133668 (from geneSymbol) uc335ouu.1 uc335ouu.1 
ENSMUST00000319975.1 ENSMUSG00000133669 ENSMUST00000319975.1 ENSMUSG00000133669 (from geneSymbol) uc335ovb.1 uc335ovb.1 
ENSMUST00000319977.1 ENSMUSG00000133670 ENSMUST00000319977.1 ENSMUSG00000133670 (from geneSymbol) uc335ovd.1 uc335ovd.1 
ENSMUST00000319978.1 ENSMUSG00000133671 ENSMUST00000319978.1 ENSMUSG00000133671 (from geneSymbol) uc335ove.1 uc335ove.1 
ENSMUST00000319979.1 ENSMUSG00000133672 ENSMUST00000319979.1 ENSMUSG00000133672 (from geneSymbol) uc335ovf.1 uc335ovf.1 
ENSMUST00000320012.1 ENSMUSG00000133673 ENSMUST00000320012.1 ENSMUSG00000133673 (from geneSymbol) uc335owj.1 uc335owj.1 
ENSMUST00000320018.1 ENSMUSG00000133674 ENSMUST00000320018.1 ENSMUSG00000133674 (from geneSymbol) uc335owp.1 uc335owp.1 
ENSMUST00000320019.1 ENSMUSG00000133675 ENSMUST00000320019.1 ENSMUSG00000133675 (from geneSymbol) uc335owq.1 uc335owq.1 
ENSMUST00000320020.1 ENSMUSG00000133676 ENSMUST00000320020.1 ENSMUSG00000133676 (from geneSymbol) uc335owr.1 uc335owr.1 
ENSMUST00000320024.1 ENSMUSG00000133677 ENSMUST00000320024.1 ENSMUSG00000133677 (from geneSymbol) uc335owv.1 uc335owv.1 
ENSMUST00000320026.1 ENSMUSG00000133678 ENSMUST00000320026.1 ENSMUSG00000133678 (from geneSymbol) uc335owx.1 uc335owx.1 
ENSMUST00000320028.1 ENSMUSG00000133679 ENSMUST00000320028.1 ENSMUSG00000133679 (from geneSymbol) uc335owz.1 uc335owz.1 
ENSMUST00000320029.1 ENSMUSG00000133680 ENSMUST00000320029.1 ENSMUSG00000133680 (from geneSymbol) uc335oxa.1 uc335oxa.1 
ENSMUST00000320030.1 A330069K06Rik ENSMUST00000320030.1 A330069K06Rik (from geneSymbol) AK039597 uc335oxb.1 uc335oxb.1 
ENSMUST00000320032.1 ENSMUSG00000133681 ENSMUST00000320032.1 ENSMUSG00000133681 (from geneSymbol) LF194121 uc335oxd.1 uc335oxd.1 
ENSMUST00000320062.1 ENSMUSG00000133682 ENSMUST00000320062.1 ENSMUSG00000133682 (from geneSymbol) uc335oyh.1 uc335oyh.1 
ENSMUST00000320063.1 ENSMUSG00000133683 ENSMUST00000320063.1 ENSMUSG00000133683 (from geneSymbol) uc335oyi.1 uc335oyi.1 
ENSMUST00000320065.1 ENSMUSG00000133684 ENSMUST00000320065.1 ENSMUSG00000133684 (from geneSymbol) uc335oyk.1 uc335oyk.1 
ENSMUST00000320072.1 ENSMUSG00000133685 ENSMUST00000320072.1 ENSMUSG00000133685 (from geneSymbol) uc335oyr.1 uc335oyr.1 
ENSMUST00000320075.1 ENSMUSG00000133686 ENSMUST00000320075.1 ENSMUSG00000133686 (from geneSymbol) uc335oyu.1 uc335oyu.1 
ENSMUST00000320084.1 Gm17619 ENSMUST00000320084.1 Gm17619 (from geneSymbol) AK080026 uc335ozd.1 uc335ozd.1 
ENSMUST00000320098.1 ENSMUSG00000133687 ENSMUST00000320098.1 ENSMUSG00000133687 (from geneSymbol) uc335ozr.1 uc335ozr.1 
ENSMUST00000320107.1 ENSMUSG00000133688 ENSMUST00000320107.1 ENSMUSG00000133688 (from geneSymbol) uc335paa.1 uc335paa.1 
ENSMUST00000320108.1 ENSMUSG00000133689 ENSMUST00000320108.1 ENSMUSG00000133689 (from geneSymbol) uc335pab.1 uc335pab.1 
ENSMUST00000320109.1 ENSMUSG00000133690 ENSMUST00000320109.1 ENSMUSG00000133690 (from geneSymbol) uc335pac.1 uc335pac.1 
ENSMUST00000320114.1 ENSMUSG00000133691 ENSMUST00000320114.1 ENSMUSG00000133691 (from geneSymbol) uc335pah.1 uc335pah.1 
ENSMUST00000320115.1 ENSMUSG00000133692 ENSMUST00000320115.1 ENSMUSG00000133692 (from geneSymbol) uc335pai.1 uc335pai.1 
ENSMUST00000320116.1 Gm43821 ENSMUST00000320116.1 Gm43821 (from geneSymbol) uc335paj.1 uc335paj.1 
ENSMUST00000320118.1 AU015791 ENSMUST00000320118.1 expressed sequence AU015791 (from RefSeq NR_102381.1) NR_102381 uc335pal.1 uc335pal.1 
ENSMUST00000320123.1 ENSMUSG00000133693 ENSMUST00000320123.1 ENSMUSG00000133693 (from geneSymbol) BC049692 uc335paq.1 uc335paq.1 
ENSMUST00000320135.1 ENSMUSG00000133694 ENSMUST00000320135.1 ENSMUSG00000133694 (from geneSymbol) uc335pbc.1 uc335pbc.1 
ENSMUST00000320145.1 ENSMUSG00000133695 ENSMUST00000320145.1 ENSMUSG00000133695 (from geneSymbol) uc335pbm.1 uc335pbm.1 
ENSMUST00000320147.1 ENSMUSG00000133697 ENSMUST00000320147.1 ENSMUSG00000133697 (from geneSymbol) uc335pbn.1 uc335pbn.1 
ENSMUST00000320148.1 ENSMUSG00000133698 ENSMUST00000320148.1 ENSMUSG00000133698 (from geneSymbol) uc335pbo.1 uc335pbo.1 
ENSMUST00000320152.1 ENSMUSG00000133699 ENSMUST00000320152.1 ENSMUSG00000133699 (from geneSymbol) uc335pbs.1 uc335pbs.1 
ENSMUST00000320155.1 ENSMUSG00000133700 ENSMUST00000320155.1 ENSMUSG00000133700 (from geneSymbol) uc335pbv.1 uc335pbv.1 
ENSMUST00000320156.1 ENSMUSG00000133701 ENSMUST00000320156.1 ENSMUSG00000133701 (from geneSymbol) uc335pbw.1 uc335pbw.1 
ENSMUST00000320161.1 ENSMUSG00000133702 ENSMUST00000320161.1 ENSMUSG00000133702 (from geneSymbol) uc335pca.1 uc335pca.1 
ENSMUST00000320163.1 ENSMUSG00000133703 ENSMUST00000320163.1 ENSMUSG00000133703 (from geneSymbol) uc335pcc.1 uc335pcc.1 
ENSMUST00000320164.1 ENSMUSG00000133704 ENSMUST00000320164.1 ENSMUSG00000133704 (from geneSymbol) uc335pcd.1 uc335pcd.1 
ENSMUST00000320167.1 ENSMUSG00000133705 ENSMUST00000320167.1 ENSMUSG00000133705 (from geneSymbol) uc335pcg.1 uc335pcg.1 
ENSMUST00000320168.1 Gm27017 ENSMUST00000320168.1 Gm27017 (from geneSymbol) uc335pch.1 uc335pch.1 
ENSMUST00000320189.1 ENSMUSG00000133706 ENSMUST00000320189.1 ENSMUSG00000133706 (from geneSymbol) uc335pdc.1 uc335pdc.1 
ENSMUST00000320191.1 ENSMUSG00000121399 ENSMUST00000320191.1 ENSMUSG00000121399 (from geneSymbol) AK079857 uc335pde.1 uc335pde.1 
ENSMUST00000320193.1 Gm56698 ENSMUST00000320193.1 Gm56698 (from geneSymbol) uc335pdg.1 uc335pdg.1 
ENSMUST00000320202.1 ENSMUSG00000133708 ENSMUST00000320202.1 ENSMUSG00000133708 (from geneSymbol) uc335pdp.1 uc335pdp.1 
ENSMUST00000320204.1 C030010L15Rik ENSMUST00000320204.1 C030010L15Rik (from geneSymbol) AK021061 uc335pdq.1 uc335pdq.1 
ENSMUST00000320213.1 Gm45351 ENSMUST00000320213.1 predicted gene 45351, transcript variant 2 (from RefSeq NR_154463.1) NR_154463 uc335pdx.1 uc335pdx.1 
ENSMUST00000320218.1 ENSMUSG00000133710 ENSMUST00000320218.1 ENSMUSG00000133710 (from geneSymbol) uc335pec.1 uc335pec.1 
ENSMUST00000320219.1 ENSMUSG00000133711 ENSMUST00000320219.1 ENSMUSG00000133711 (from geneSymbol) uc335ped.1 uc335ped.1 
ENSMUST00000320220.1 ENSMUSG00000133712 ENSMUST00000320220.1 ENSMUSG00000133712 (from geneSymbol) uc335pee.1 uc335pee.1 
ENSMUST00000320227.1 ENSMUSG00000133713 ENSMUST00000320227.1 ENSMUSG00000133713 (from geneSymbol) uc335pel.1 uc335pel.1 
ENSMUST00000320228.1 ENSMUSG00000133714 ENSMUST00000320228.1 ENSMUSG00000133714 (from geneSymbol) LF194883 uc335pem.1 uc335pem.1 
ENSMUST00000320229.1 Gm37892 ENSMUST00000320229.1 Gm37892 (from geneSymbol) uc335pen.1 uc335pen.1 
ENSMUST00000320231.1 ENSMUSG00000133715 ENSMUST00000320231.1 ENSMUSG00000133715 (from geneSymbol) uc335pep.1 uc335pep.1 
ENSMUST00000320233.1 Gm14004 ENSMUST00000320233.1 Gm14004 (from geneSymbol) AK030357 uc335per.1 uc335per.1 
ENSMUST00000320286.1 Gm40375 ENSMUST00000320286.1 Gm40375 (from geneSymbol) uc335pgr.1 uc335pgr.1 
ENSMUST00000320294.1 ENSMUSG00000133716 ENSMUST00000320294.1 ENSMUSG00000133716 (from geneSymbol) uc335pgz.1 uc335pgz.1 
ENSMUST00000320304.1 ENSMUSG00000133717 ENSMUST00000320304.1 ENSMUSG00000133717 (from geneSymbol) uc335phj.1 uc335phj.1 
ENSMUST00000320305.1 ENSMUSG00000133718 ENSMUST00000320305.1 ENSMUSG00000133718 (from geneSymbol) uc335phk.1 uc335phk.1 
ENSMUST00000320316.1 Gm44386 ENSMUST00000320316.1 Gm44386 (from geneSymbol) AK079912 uc335phv.1 uc335phv.1 
ENSMUST00000320317.1 ENSMUSG00000133719 ENSMUST00000320317.1 ENSMUSG00000133719 (from geneSymbol) uc335phw.1 uc335phw.1 
ENSMUST00000320319.1 ENSMUSG00000133720 ENSMUST00000320319.1 ENSMUSG00000133720 (from geneSymbol) uc335phy.1 uc335phy.1 
ENSMUST00000320321.1 ENSMUSG00000133721 ENSMUST00000320321.1 ENSMUSG00000133721 (from geneSymbol) uc335pia.1 uc335pia.1 
ENSMUST00000320322.1 ENSMUSG00000133722 ENSMUST00000320322.1 ENSMUSG00000133722 (from geneSymbol) uc335pib.1 uc335pib.1 
ENSMUST00000320324.1 ENSMUSG00000133723 ENSMUST00000320324.1 ENSMUSG00000133723 (from geneSymbol) AK041647 uc335pid.1 uc335pid.1 
ENSMUST00000320330.1 ENSMUSG00000133724 ENSMUST00000320330.1 ENSMUSG00000133724 (from geneSymbol) uc335pij.1 uc335pij.1 
ENSMUST00000320331.1 ENSMUSG00000133725 ENSMUST00000320331.1 ENSMUSG00000133725 (from geneSymbol) uc335pik.1 uc335pik.1 
ENSMUST00000320332.1 ENSMUSG00000133726 ENSMUST00000320332.1 ENSMUSG00000133726 (from geneSymbol) uc335pil.1 uc335pil.1 
ENSMUST00000320335.1 Gm26652 ENSMUST00000320335.1 Gm26652 (from geneSymbol) AK170409 uc335pio.1 uc335pio.1 
ENSMUST00000320357.1 ENSMUSG00000133727 ENSMUST00000320357.1 ENSMUSG00000133727 (from geneSymbol) uc335pjk.1 uc335pjk.1 
ENSMUST00000320358.1 ENSMUSG00000133728 ENSMUST00000320358.1 ENSMUSG00000133728 (from geneSymbol) uc335pjl.1 uc335pjl.1 
ENSMUST00000320359.1 Gm56648 ENSMUST00000320359.1 Gm56648 (from geneSymbol) uc335pjm.1 uc335pjm.1 
ENSMUST00000320362.1 ENSMUSG00000133729 ENSMUST00000320362.1 ENSMUSG00000133729 (from geneSymbol) uc335pjp.1 uc335pjp.1 
ENSMUST00000320367.1 ENSMUSG00000133730 ENSMUST00000320367.1 ENSMUSG00000133730 (from geneSymbol) uc335pju.1 uc335pju.1 
ENSMUST00000320368.1 ENSMUSG00000133731 ENSMUST00000320368.1 ENSMUSG00000133731 (from geneSymbol) uc335pjv.1 uc335pjv.1 
ENSMUST00000320369.1 ENSMUSG00000133732 ENSMUST00000320369.1 ENSMUSG00000133732 (from geneSymbol) uc335pjw.1 uc335pjw.1 
ENSMUST00000320372.1 ENSMUSG00000133734 ENSMUST00000320372.1 ENSMUSG00000133734 (from geneSymbol) uc335pjy.1 uc335pjy.1 
ENSMUST00000320374.1 ENSMUSG00000133735 ENSMUST00000320374.1 ENSMUSG00000133735 (from geneSymbol) uc335pka.1 uc335pka.1 
ENSMUST00000320377.1 ENSMUSG00000133736 ENSMUST00000320377.1 ENSMUSG00000133736 (from geneSymbol) uc335pkd.1 uc335pkd.1 
ENSMUST00000320378.1 ENSMUSG00000133737 ENSMUST00000320378.1 ENSMUSG00000133737 (from geneSymbol) uc335pke.1 uc335pke.1 
ENSMUST00000320379.1 ENSMUSG00000133738 ENSMUST00000320379.1 ENSMUSG00000133738 (from geneSymbol) uc335pkf.1 uc335pkf.1 
ENSMUST00000320382.1 ENSMUSG00000133739 ENSMUST00000320382.1 ENSMUSG00000133739 (from geneSymbol) uc335pki.1 uc335pki.1 
ENSMUST00000320383.1 ENSMUSG00000121754 ENSMUST00000320383.1 ENSMUSG00000121754 (from geneSymbol) uc335pkj.1 uc335pkj.1 
ENSMUST00000320384.1 ENSMUSG00000133740 ENSMUST00000320384.1 ENSMUSG00000133740 (from geneSymbol) uc335pkk.1 uc335pkk.1 
ENSMUST00000320403.1 ENSMUSG00000133741 ENSMUST00000320403.1 ENSMUSG00000133741 (from geneSymbol) uc335pld.1 uc335pld.1 
ENSMUST00000320405.1 ENSMUSG00000133742 ENSMUST00000320405.1 ENSMUSG00000133742 (from geneSymbol) uc335plf.1 uc335plf.1 
ENSMUST00000320422.1 ENSMUSG00000133743 ENSMUST00000320422.1 ENSMUSG00000133743 (from geneSymbol) uc335plw.1 uc335plw.1 
ENSMUST00000320425.1 ENSMUSG00000133744 ENSMUST00000320425.1 ENSMUSG00000133744 (from geneSymbol) uc335plz.1 uc335plz.1 
ENSMUST00000320454.1 ENSMUSG00000133745 ENSMUST00000320454.1 ENSMUSG00000133745 (from geneSymbol) uc335pnb.1 uc335pnb.1 
ENSMUST00000320456.1 ENSMUSG00000133746 ENSMUST00000320456.1 ENSMUSG00000133746 (from geneSymbol) uc335pnd.1 uc335pnd.1 
ENSMUST00000320462.1 ENSMUSG00000133747 ENSMUST00000320462.1 ENSMUSG00000133747 (from geneSymbol) uc335pnj.1 uc335pnj.1 
ENSMUST00000320463.1 ENSMUSG00000133748 ENSMUST00000320463.1 ENSMUSG00000133748 (from geneSymbol) uc335pnk.1 uc335pnk.1 
ENSMUST00000320471.1 ENSMUSG00000133749 ENSMUST00000320471.1 ENSMUSG00000133749 (from geneSymbol) uc335pnr.1 uc335pnr.1 
ENSMUST00000320472.1 ENSMUSG00000133750 ENSMUST00000320472.1 ENSMUSG00000133750 (from geneSymbol) uc335pns.1 uc335pns.1 
ENSMUST00000320474.1 ENSMUSG00000133751 ENSMUST00000320474.1 ENSMUSG00000133751 (from geneSymbol) uc335pnu.1 uc335pnu.1 
ENSMUST00000320475.1 ENSMUSG00000133752 ENSMUST00000320475.1 ENSMUSG00000133752 (from geneSymbol) uc335pnv.1 uc335pnv.1 
ENSMUST00000320479.1 ENSMUSG00000133753 ENSMUST00000320479.1 ENSMUSG00000133753 (from geneSymbol) uc335pnz.1 uc335pnz.1 
ENSMUST00000320481.1 ENSMUSG00000133754 ENSMUST00000320481.1 ENSMUSG00000133754 (from geneSymbol) uc335pob.1 uc335pob.1 
ENSMUST00000320482.1 ENSMUSG00000133755 ENSMUST00000320482.1 ENSMUSG00000133755 (from geneSymbol) uc335poc.1 uc335poc.1 
ENSMUST00000320483.1 ENSMUSG00000133756 ENSMUST00000320483.1 ENSMUSG00000133756 (from geneSymbol) uc335pod.1 uc335pod.1 
ENSMUST00000320485.1 ENSMUSG00000133757 ENSMUST00000320485.1 ENSMUSG00000133757 (from geneSymbol) uc335poe.1 uc335poe.1 
ENSMUST00000320487.1 ENSMUSG00000133758 ENSMUST00000320487.1 ENSMUSG00000133758 (from geneSymbol) uc335pog.1 uc335pog.1 
ENSMUST00000320488.1 ENSMUSG00000133759 ENSMUST00000320488.1 ENSMUSG00000133759 (from geneSymbol) uc335poh.1 uc335poh.1 
ENSMUST00000320491.1 ENSMUSG00000133760 ENSMUST00000320491.1 ENSMUSG00000133760 (from geneSymbol) uc335pok.1 uc335pok.1 
ENSMUST00000320501.1 ENSMUSG00000133761 ENSMUST00000320501.1 ENSMUSG00000133761 (from geneSymbol) uc335pot.1 uc335pot.1 
ENSMUST00000320503.1 ENSMUSG00000133762 ENSMUST00000320503.1 ENSMUSG00000133762 (from geneSymbol) uc335pov.1 uc335pov.1 
ENSMUST00000320516.1 ENSMUSG00000133763 ENSMUST00000320516.1 ENSMUSG00000133763 (from geneSymbol) uc335ppi.1 uc335ppi.1 
ENSMUST00000320518.1 ENSMUSG00000133765 ENSMUST00000320518.1 ENSMUSG00000133765 (from geneSymbol) uc335ppj.1 uc335ppj.1 
ENSMUST00000320520.1 ENSMUSG00000133766 ENSMUST00000320520.1 ENSMUSG00000133766 (from geneSymbol) uc335ppl.1 uc335ppl.1 
ENSMUST00000320532.1 ENSMUSG00000133767 ENSMUST00000320532.1 ENSMUSG00000133767 (from geneSymbol) uc335ppx.1 uc335ppx.1 
ENSMUST00000320535.1 ENSMUSG00000133768 ENSMUST00000320535.1 ENSMUSG00000133768 (from geneSymbol) uc335pqa.1 uc335pqa.1 
ENSMUST00000320537.1 ENSMUSG00000133769 ENSMUST00000320537.1 ENSMUSG00000133769 (from geneSymbol) uc335pqc.1 uc335pqc.1 
ENSMUST00000320542.1 ENSMUSG00000133770 ENSMUST00000320542.1 ENSMUSG00000133770 (from geneSymbol) uc335pqh.1 uc335pqh.1 
ENSMUST00000320559.1 ENSMUSG00000133771 ENSMUST00000320559.1 ENSMUSG00000133771 (from geneSymbol) uc335pqy.1 uc335pqy.1 
ENSMUST00000320560.1 Gm50351 ENSMUST00000320560.1 Gm50351 (from geneSymbol) uc335pqz.1 uc335pqz.1 
ENSMUST00000320570.1 ENSMUSG00000133772 ENSMUST00000320570.1 ENSMUSG00000133772 (from geneSymbol) uc335prj.1 uc335prj.1 
ENSMUST00000320574.1 ENSMUSG00000133773 ENSMUST00000320574.1 ENSMUSG00000133773 (from geneSymbol) uc335prn.1 uc335prn.1 
ENSMUST00000320576.1 ENSMUSG00000133774 ENSMUST00000320576.1 ENSMUSG00000133774 (from geneSymbol) uc335prp.1 uc335prp.1 
ENSMUST00000320581.1 ENSMUSG00000133775 ENSMUST00000320581.1 ENSMUSG00000133775 (from geneSymbol) uc335pru.1 uc335pru.1 
ENSMUST00000320582.1 ENSMUSG00000133776 ENSMUST00000320582.1 ENSMUSG00000133776 (from geneSymbol) uc335prv.1 uc335prv.1 
ENSMUST00000320742.1 ENSMUSG00000133777 ENSMUST00000320742.1 ENSMUSG00000133777 (from geneSymbol) uc335pxy.1 uc335pxy.1 
ENSMUST00000320743.1 ENSMUSG00000133778 ENSMUST00000320743.1 ENSMUSG00000133778 (from geneSymbol) uc335pxz.1 uc335pxz.1 
ENSMUST00000320744.1 ENSMUSG00000133779 ENSMUST00000320744.1 ENSMUSG00000133779 (from geneSymbol) uc335pya.1 uc335pya.1 
ENSMUST00000320745.1 ENSMUSG00000133780 ENSMUST00000320745.1 ENSMUSG00000133780 (from geneSymbol) uc335pyb.1 uc335pyb.1 
ENSMUST00000320746.1 ENSMUSG00000133781 ENSMUST00000320746.1 ENSMUSG00000133781 (from geneSymbol) uc335pyc.1 uc335pyc.1 
ENSMUST00000320747.1 4930429H19Rik ENSMUST00000320747.1 4930429H19Rik (from geneSymbol) AK133139 uc335pyd.1 uc335pyd.1 
ENSMUST00000320802.1 ENSMUSG00000133782 ENSMUST00000320802.1 ENSMUSG00000133782 (from geneSymbol) uc335qaf.1 uc335qaf.1 
ENSMUST00000320803.1 ENSMUSG00000133783 ENSMUST00000320803.1 ENSMUSG00000133783 (from geneSymbol) uc335qag.1 uc335qag.1 
ENSMUST00000320805.1 ENSMUSG00000133784 ENSMUST00000320805.1 ENSMUSG00000133784 (from geneSymbol) uc335qai.1 uc335qai.1 
ENSMUST00000320809.1 ENSMUSG00000133785 ENSMUST00000320809.1 ENSMUSG00000133785 (from geneSymbol) uc335qam.1 uc335qam.1 
ENSMUST00000320811.1 ENSMUSG00000133786 ENSMUST00000320811.1 ENSMUSG00000133786 (from geneSymbol) uc335qao.1 uc335qao.1 
ENSMUST00000320818.1 ENSMUSG00000133787 ENSMUST00000320818.1 ENSMUSG00000133787 (from geneSymbol) uc335qav.1 uc335qav.1 
ENSMUST00000320820.1 ENSMUSG00000133788 ENSMUST00000320820.1 ENSMUSG00000133788 (from geneSymbol) uc335qax.1 uc335qax.1 
ENSMUST00000320821.1 ENSMUSG00000133789 ENSMUST00000320821.1 ENSMUSG00000133789 (from geneSymbol) uc335qay.1 uc335qay.1 
ENSMUST00000320822.1 Gm56748 ENSMUST00000320822.1 Gm56748 (from geneSymbol) uc335qaz.1 uc335qaz.1 
ENSMUST00000320825.1 ENSMUSG00000133790 ENSMUST00000320825.1 ENSMUSG00000133790 (from geneSymbol) uc335qbc.1 uc335qbc.1 
ENSMUST00000320826.1 ENSMUSG00000133791 ENSMUST00000320826.1 ENSMUSG00000133791 (from geneSymbol) uc335qbd.1 uc335qbd.1 
ENSMUST00000320828.1 Gm2155 ENSMUST00000320828.1 Gm2155 (from geneSymbol) AK139105 uc335qbf.1 uc335qbf.1 
ENSMUST00000320830.1 ENSMUSG00000133792 ENSMUST00000320830.1 ENSMUSG00000133792 (from geneSymbol) uc335qbh.1 uc335qbh.1 
ENSMUST00000320833.1 ENSMUSG00000133793 ENSMUST00000320833.1 ENSMUSG00000133793 (from geneSymbol) uc335qbk.1 uc335qbk.1 
ENSMUST00000320850.1 ENSMUSG00000133794 ENSMUST00000320850.1 ENSMUSG00000133794 (from geneSymbol) uc335qcb.1 uc335qcb.1 
ENSMUST00000320856.1 ENSMUSG00000133795 ENSMUST00000320856.1 ENSMUSG00000133795 (from geneSymbol) uc335qch.1 uc335qch.1 
ENSMUST00000320857.1 ENSMUSG00000133796 ENSMUST00000320857.1 ENSMUSG00000133796 (from geneSymbol) uc335qci.1 uc335qci.1 
ENSMUST00000320871.1 ENSMUSG00000133797 ENSMUST00000320871.1 ENSMUSG00000133797 (from geneSymbol) uc335qcw.1 uc335qcw.1 
ENSMUST00000320872.1 ENSMUSG00000133798 ENSMUST00000320872.1 ENSMUSG00000133798 (from geneSymbol) uc335qcx.1 uc335qcx.1 
ENSMUST00000320875.1 Gm45631 ENSMUST00000320875.1 Gm45631 (from geneSymbol) AK016058 uc335qda.1 uc335qda.1 
ENSMUST00000320876.1 Gm29932 ENSMUST00000320876.1 Gm29932 (from geneSymbol) uc335qdb.1 uc335qdb.1 
ENSMUST00000320878.1 ENSMUSG00000133800 ENSMUST00000320878.1 ENSMUSG00000133800 (from geneSymbol) uc335qdd.1 uc335qdd.1 
ENSMUST00000320882.1 Gm12092 ENSMUST00000320882.1 Gm12092 (from geneSymbol) AK084560 uc335qdh.1 uc335qdh.1 
ENSMUST00000320894.1 ENSMUSG00000133801 ENSMUST00000320894.1 ENSMUSG00000133801 (from geneSymbol) uc335qdt.1 uc335qdt.1 
ENSMUST00000320895.1 ENSMUSG00000133802 ENSMUST00000320895.1 ENSMUSG00000133802 (from geneSymbol) uc335qdu.1 uc335qdu.1 
ENSMUST00000320896.1 ENSMUSG00000133803 ENSMUST00000320896.1 ENSMUSG00000133803 (from geneSymbol) uc335qdv.1 uc335qdv.1 
ENSMUST00000320898.1 ENSMUSG00000133804 ENSMUST00000320898.1 ENSMUSG00000133804 (from geneSymbol) uc335qdx.1 uc335qdx.1 
ENSMUST00000320899.1 ENSMUSG00000133805 ENSMUST00000320899.1 ENSMUSG00000133805 (from geneSymbol) uc335qdy.1 uc335qdy.1 
ENSMUST00000320906.1 ENSMUSG00000133806 ENSMUST00000320906.1 ENSMUSG00000133806 (from geneSymbol) uc335qef.1 uc335qef.1 
ENSMUST00000320908.1 1700093J21Rik ENSMUST00000320908.1 1700093J21Rik (from geneSymbol) AK007051 uc335qeh.1 uc335qeh.1 
ENSMUST00000320913.1 ENSMUSG00000133807 ENSMUST00000320913.1 ENSMUSG00000133807 (from geneSymbol) uc335qem.1 uc335qem.1 
ENSMUST00000320915.1 ENSMUSG00000133808 ENSMUST00000320915.1 ENSMUSG00000133808 (from geneSymbol) uc335qeo.1 uc335qeo.1 
ENSMUST00000320918.1 ENSMUSG00000133809 ENSMUST00000320918.1 ENSMUSG00000133809 (from geneSymbol) AK145544 uc335qer.1 uc335qer.1 
ENSMUST00000320919.1 ENSMUSG00000133810 ENSMUST00000320919.1 ENSMUSG00000133810 (from geneSymbol) uc335qes.1 uc335qes.1 
ENSMUST00000320921.1 ENSMUSG00000133812 ENSMUST00000320921.1 ENSMUSG00000133812 (from geneSymbol) uc335qet.1 uc335qet.1 
ENSMUST00000320922.1 ENSMUSG00000133813 ENSMUST00000320922.1 ENSMUSG00000133813 (from geneSymbol) uc335qeu.1 uc335qeu.1 
ENSMUST00000320923.1 ENSMUSG00000133814 ENSMUST00000320923.1 ENSMUSG00000133814 (from geneSymbol) uc335qev.1 uc335qev.1 
ENSMUST00000320926.1 ENSMUSG00000133815 ENSMUST00000320926.1 ENSMUSG00000133815 (from geneSymbol) uc335qey.1 uc335qey.1 
ENSMUST00000320933.1 ENSMUSG00000133816 ENSMUST00000320933.1 ENSMUSG00000133816 (from geneSymbol) uc335qff.1 uc335qff.1 
ENSMUST00000320935.1 ENSMUSG00000133817 ENSMUST00000320935.1 ENSMUSG00000133817 (from geneSymbol) AK006024 uc335qfh.1 uc335qfh.1 
ENSMUST00000320942.1 ENSMUSG00000133818 ENSMUST00000320942.1 ENSMUSG00000133818 (from geneSymbol) BC089498 uc335qfo.1 uc335qfo.1 
ENSMUST00000320943.1 ENSMUSG00000133819 ENSMUST00000320943.1 ENSMUSG00000133819 (from geneSymbol) uc335qfp.1 uc335qfp.1 
ENSMUST00000320945.1 ENSMUSG00000133820 ENSMUST00000320945.1 ENSMUSG00000133820 (from geneSymbol) uc335qfr.1 uc335qfr.1 
ENSMUST00000320946.1 ENSMUSG00000133821 ENSMUST00000320946.1 ENSMUSG00000133821 (from geneSymbol) uc335qfs.1 uc335qfs.1 
ENSMUST00000320948.1 ENSMUSG00000133822 ENSMUST00000320948.1 ENSMUSG00000133822 (from geneSymbol) uc335qfu.1 uc335qfu.1 
ENSMUST00000320953.1 1110019D14Rik ENSMUST00000320953.1 1110019D14Rik (from geneSymbol) AK143417 uc335qfz.1 uc335qfz.1 
ENSMUST00000320977.1 ENSMUSG00000133823 ENSMUST00000320977.1 ENSMUSG00000133823 (from geneSymbol) uc335qgx.1 uc335qgx.1 
ENSMUST00000320979.1 Gm41396 ENSMUST00000320979.1 Gm41396 (from geneSymbol) KY467738 uc335qgz.1 uc335qgz.1 
ENSMUST00000320994.1 ENSMUSG00000133824 ENSMUST00000320994.1 ENSMUSG00000133824 (from geneSymbol) uc335qho.1 uc335qho.1 
ENSMUST00000320995.1 ENSMUSG00000133825 ENSMUST00000320995.1 ENSMUSG00000133825 (from geneSymbol) uc335qhp.1 uc335qhp.1 
ENSMUST00000320996.1 ENSMUSG00000133826 ENSMUST00000320996.1 ENSMUSG00000133826 (from geneSymbol) uc335qhq.1 uc335qhq.1 
ENSMUST00000320998.1 ENSMUSG00000133827 ENSMUST00000320998.1 ENSMUSG00000133827 (from geneSymbol) BC087891 uc335qhs.1 uc335qhs.1 
ENSMUST00000320999.1 ENSMUSG00000133828 ENSMUST00000320999.1 ENSMUSG00000133828 (from geneSymbol) uc335qht.1 uc335qht.1 
ENSMUST00000321003.1 ENSMUSG00000133829 ENSMUST00000321003.1 ENSMUSG00000133829 (from geneSymbol) uc335qhx.1 uc335qhx.1 
ENSMUST00000321009.1 ENSMUSG00000133830 ENSMUST00000321009.1 ENSMUSG00000133830 (from geneSymbol) uc335qid.1 uc335qid.1 
ENSMUST00000321011.1 ENSMUSG00000133831 ENSMUST00000321011.1 ENSMUSG00000133831 (from geneSymbol) uc335qif.1 uc335qif.1 
ENSMUST00000321013.1 ENSMUSG00000133832 ENSMUST00000321013.1 ENSMUSG00000133832 (from geneSymbol) uc335qih.1 uc335qih.1 
ENSMUST00000321015.1 ENSMUSG00000133833 ENSMUST00000321015.1 ENSMUSG00000133833 (from geneSymbol) uc335qij.1 uc335qij.1 
ENSMUST00000321020.1 Gm26510 ENSMUST00000321020.1 Gm26510 (from geneSymbol) AK040904 uc335qin.1 uc335qin.1 
ENSMUST00000321115.1 ENSMUSG00000133834 ENSMUST00000321115.1 ENSMUSG00000133834 (from geneSymbol) uc335qme.1 uc335qme.1 
ENSMUST00000321117.1 ENSMUSG00000133835 ENSMUST00000321117.1 ENSMUSG00000133835 (from geneSymbol) uc335qmg.1 uc335qmg.1 
ENSMUST00000321119.1 ENSMUSG00000133836 ENSMUST00000321119.1 ENSMUSG00000133836 (from geneSymbol) uc335qmi.1 uc335qmi.1 
ENSMUST00000321124.1 ENSMUSG00000133837 ENSMUST00000321124.1 ENSMUSG00000133837 (from geneSymbol) uc335qmn.1 uc335qmn.1 
ENSMUST00000321125.1 ENSMUSG00000133838 ENSMUST00000321125.1 ENSMUSG00000133838 (from geneSymbol) uc335qmo.1 uc335qmo.1 
ENSMUST00000321127.1 ENSMUSG00000133839 ENSMUST00000321127.1 ENSMUSG00000133839 (from geneSymbol) uc335qmq.1 uc335qmq.1 
ENSMUST00000321129.1 ENSMUSG00000133840 ENSMUST00000321129.1 ENSMUSG00000133840 (from geneSymbol) uc335qms.1 uc335qms.1 
ENSMUST00000321130.1 ENSMUSG00000133841 ENSMUST00000321130.1 ENSMUSG00000133841 (from geneSymbol) uc335qmt.1 uc335qmt.1 
ENSMUST00000321131.1 ENSMUSG00000133842 ENSMUST00000321131.1 ENSMUSG00000133842 (from geneSymbol) uc335qmu.1 uc335qmu.1 
ENSMUST00000321134.1 ENSMUSG00000133843 ENSMUST00000321134.1 ENSMUSG00000133843 (from geneSymbol) uc335qmx.1 uc335qmx.1 
ENSMUST00000321136.1 ENSMUSG00000133844 ENSMUST00000321136.1 ENSMUSG00000133844 (from geneSymbol) uc335qmz.1 uc335qmz.1 
ENSMUST00000321137.1 ENSMUSG00000133845 ENSMUST00000321137.1 ENSMUSG00000133845 (from geneSymbol) LF204275 uc335qna.1 uc335qna.1 
ENSMUST00000321139.1 ENSMUSG00000133847 ENSMUST00000321139.1 ENSMUSG00000133847 (from geneSymbol) uc335qnb.1 uc335qnb.1 
ENSMUST00000321140.1 ENSMUSG00000133848 ENSMUST00000321140.1 ENSMUSG00000133848 (from geneSymbol) uc335qnc.1 uc335qnc.1 
ENSMUST00000321141.1 Gm33912 ENSMUST00000321141.1 Gm33912 (from geneSymbol) uc335qnd.1 uc335qnd.1 
ENSMUST00000321149.1 ENSMUSG00000133849 ENSMUST00000321149.1 ENSMUSG00000133849 (from geneSymbol) uc335qnl.1 uc335qnl.1 
ENSMUST00000321150.1 ENSMUSG00000133850 ENSMUST00000321150.1 ENSMUSG00000133850 (from geneSymbol) uc335qnm.1 uc335qnm.1 
ENSMUST00000321151.1 Discn ENSMUST00000321151.1 Discn (from geneSymbol) uc335qnn.1 uc335qnn.1 
ENSMUST00000321152.1 ENSMUSG00000133851 ENSMUST00000321152.1 ENSMUSG00000133851 (from geneSymbol) uc335qno.1 uc335qno.1 
ENSMUST00000321155.1 ENSMUSG00000133852 ENSMUST00000321155.1 ENSMUSG00000133852 (from geneSymbol) LF201713 uc335qnr.1 uc335qnr.1 
ENSMUST00000321156.1 ENSMUSG00000133853 ENSMUST00000321156.1 ENSMUSG00000133853 (from geneSymbol) uc335qns.1 uc335qns.1 
ENSMUST00000321157.1 ENSMUSG00000133854 ENSMUST00000321157.1 ENSMUSG00000133854 (from geneSymbol) uc335qnt.1 uc335qnt.1 
ENSMUST00000321159.1 ENSMUSG00000133855 ENSMUST00000321159.1 ENSMUSG00000133855 (from geneSymbol) uc335qnv.1 uc335qnv.1 
ENSMUST00000321160.1 ENSMUSG00000133856 ENSMUST00000321160.1 ENSMUSG00000133856 (from geneSymbol) uc335qnw.1 uc335qnw.1 
ENSMUST00000321164.1 ENSMUSG00000133857 ENSMUST00000321164.1 ENSMUSG00000133857 (from geneSymbol) uc335qoa.1 uc335qoa.1 
ENSMUST00000321166.1 ENSMUSG00000133858 ENSMUST00000321166.1 ENSMUSG00000133858 (from geneSymbol) uc335qoc.1 uc335qoc.1 
ENSMUST00000321168.1 ENSMUSG00000133860 ENSMUST00000321168.1 ENSMUSG00000133860 (from geneSymbol) uc335qod.1 uc335qod.1 
ENSMUST00000321170.1 ENSMUSG00000133861 ENSMUST00000321170.1 ENSMUSG00000133861 (from geneSymbol) uc335qof.1 uc335qof.1 
ENSMUST00000321225.1 ENSMUSG00000133862 ENSMUST00000321225.1 ENSMUSG00000133862 (from geneSymbol) uc335qqi.1 uc335qqi.1 
ENSMUST00000321229.1 Gm31115 ENSMUST00000321229.1 Gm31115 (from geneSymbol) uc335qqm.1 uc335qqm.1 
ENSMUST00000321239.1 ENSMUSG00000133863 ENSMUST00000321239.1 ENSMUSG00000133863 (from geneSymbol) uc335qqw.1 uc335qqw.1 
ENSMUST00000321241.1 ENSMUSG00000133864 ENSMUST00000321241.1 ENSMUSG00000133864 (from geneSymbol) uc335qqy.1 uc335qqy.1 
ENSMUST00000321242.1 ENSMUSG00000133865 ENSMUST00000321242.1 ENSMUSG00000133865 (from geneSymbol) uc335qqz.1 uc335qqz.1 
ENSMUST00000321243.1 ENSMUSG00000133866 ENSMUST00000321243.1 ENSMUSG00000133866 (from geneSymbol) uc335qra.1 uc335qra.1 
ENSMUST00000321245.1 ENSMUSG00000133867 ENSMUST00000321245.1 ENSMUSG00000133867 (from geneSymbol) uc335qrc.1 uc335qrc.1 
ENSMUST00000321251.1 ENSMUSG00000133868 ENSMUST00000321251.1 ENSMUSG00000133868 (from geneSymbol) uc335qri.1 uc335qri.1 
ENSMUST00000321256.1 ENSMUSG00000133869 ENSMUST00000321256.1 ENSMUSG00000133869 (from geneSymbol) uc335qrn.1 uc335qrn.1 
ENSMUST00000321258.1 ENSMUSG00000133870 ENSMUST00000321258.1 ENSMUSG00000133870 (from geneSymbol) uc335qrp.1 uc335qrp.1 
ENSMUST00000321261.1 Gm56950 ENSMUST00000321261.1 Gm56950 (from geneSymbol) uc335qrs.1 uc335qrs.1 
ENSMUST00000321266.1 ENSMUSG00000133871 ENSMUST00000321266.1 ENSMUSG00000133871 (from geneSymbol) uc335qrx.1 uc335qrx.1 
ENSMUST00000321276.1 Gm56613 ENSMUST00000321276.1 Gm56613 (from geneSymbol) uc335qsh.1 uc335qsh.1 
ENSMUST00000321286.1 ENSMUSG00000133872 ENSMUST00000321286.1 ENSMUSG00000133872 (from geneSymbol) uc335qsr.1 uc335qsr.1 
ENSMUST00000321287.1 ENSMUSG00000133873 ENSMUST00000321287.1 ENSMUSG00000133873 (from geneSymbol) uc335qss.1 uc335qss.1 
ENSMUST00000321288.1 ENSMUSG00000133874 ENSMUST00000321288.1 ENSMUSG00000133874 (from geneSymbol) uc335qst.1 uc335qst.1 
ENSMUST00000321293.1 ENSMUSG00000133875 ENSMUST00000321293.1 ENSMUSG00000133875 (from geneSymbol) uc335qsy.1 uc335qsy.1 
ENSMUST00000321294.1 ENSMUSG00000133876 ENSMUST00000321294.1 ENSMUSG00000133876 (from geneSymbol) uc335qsz.1 uc335qsz.1 
ENSMUST00000321297.1 ENSMUSG00000133877 ENSMUST00000321297.1 ENSMUSG00000133877 (from geneSymbol) uc335qtc.1 uc335qtc.1 
ENSMUST00000321298.1 ENSMUSG00000133878 ENSMUST00000321298.1 ENSMUSG00000133878 (from geneSymbol) uc335qtd.1 uc335qtd.1 
ENSMUST00000321301.1 Gm57212 ENSMUST00000321301.1 Gm57212 (from geneSymbol) uc335qtf.1 uc335qtf.1 
ENSMUST00000321323.1 Gm20484 ENSMUST00000321323.1 Gm20484 (from geneSymbol) uc335qub.1 uc335qub.1 
ENSMUST00000321336.1 ENSMUSG00000133879 ENSMUST00000321336.1 ENSMUSG00000133879 (from geneSymbol) uc335quo.1 uc335quo.1 
ENSMUST00000321338.1 ENSMUSG00000133880 ENSMUST00000321338.1 ENSMUSG00000133880 (from geneSymbol) uc335quq.1 uc335quq.1 
ENSMUST00000321339.1 ENSMUSG00000133881 ENSMUST00000321339.1 ENSMUSG00000133881 (from geneSymbol) uc335qur.1 uc335qur.1 
ENSMUST00000321350.1 ENSMUSG00000133882 ENSMUST00000321350.1 ENSMUSG00000133882 (from geneSymbol) uc335qvc.1 uc335qvc.1 
ENSMUST00000321351.1 ENSMUSG00000133883 ENSMUST00000321351.1 ENSMUSG00000133883 (from geneSymbol) uc335qvd.1 uc335qvd.1 
ENSMUST00000321353.1 ENSMUSG00000133884 ENSMUST00000321353.1 ENSMUSG00000133884 (from geneSymbol) uc335qvf.1 uc335qvf.1 
ENSMUST00000321358.1 ENSMUSG00000133885 ENSMUST00000321358.1 ENSMUSG00000133885 (from geneSymbol) uc335qvk.1 uc335qvk.1 
ENSMUST00000321359.1 Gm17396 ENSMUST00000321359.1 Gm17396 (from geneSymbol) AK086087 uc335qvl.1 uc335qvl.1 
ENSMUST00000321362.1 ENSMUSG00000133886 ENSMUST00000321362.1 ENSMUSG00000133886 (from geneSymbol) uc335qvo.1 uc335qvo.1 
ENSMUST00000321365.1 1700123J17Rik ENSMUST00000321365.1 1700123J17Rik (from geneSymbol) AK043947 uc335qvr.1 uc335qvr.1 
ENSMUST00000321369.1 ENSMUSG00000133887 ENSMUST00000321369.1 ENSMUSG00000133887 (from geneSymbol) uc335qvu.1 uc335qvu.1 
ENSMUST00000321372.1 ENSMUSG00000133888 ENSMUST00000321372.1 ENSMUSG00000133888 (from geneSymbol) uc335qvx.1 uc335qvx.1 
ENSMUST00000321374.1 ENSMUSG00000133889 ENSMUST00000321374.1 ENSMUSG00000133889 (from geneSymbol) uc335qvz.1 uc335qvz.1 
ENSMUST00000321377.1 ENSMUSG00000133890 ENSMUST00000321377.1 ENSMUSG00000133890 (from geneSymbol) uc335qwc.1 uc335qwc.1 
ENSMUST00000321379.1 ENSMUSG00000133891 ENSMUST00000321379.1 predicted gene, 32755 (from RefSeq NR_136890.1) NR_136890 uc335qwe.1 uc335qwe.1 
ENSMUST00000321380.1 ENSMUSG00000133892 ENSMUST00000321380.1 ENSMUSG00000133892 (from geneSymbol) uc335qwf.1 uc335qwf.1 
ENSMUST00000321381.1 ENSMUSG00000133893 ENSMUST00000321381.1 ENSMUSG00000133893 (from geneSymbol) uc335qwg.1 uc335qwg.1 
ENSMUST00000321386.1 ENSMUSG00000133894 ENSMUST00000321386.1 ENSMUSG00000133894 (from geneSymbol) uc335qwl.1 uc335qwl.1 
ENSMUST00000321387.1 ENSMUSG00000133895 ENSMUST00000321387.1 ENSMUSG00000133895 (from geneSymbol) uc335qwm.1 uc335qwm.1 
ENSMUST00000321389.1 ENSMUSG00000133896 ENSMUST00000321389.1 ENSMUSG00000133896 (from geneSymbol) uc335qwo.1 uc335qwo.1 
ENSMUST00000321391.1 ENSMUSG00000133897 ENSMUST00000321391.1 ENSMUSG00000133897 (from geneSymbol) uc335qwq.1 uc335qwq.1 
ENSMUST00000321392.1 2900076A07Rik ENSMUST00000321392.1 2900076A07Rik (from geneSymbol) KY468144 uc335qwr.1 uc335qwr.1 
ENSMUST00000321424.1 1700024J04Rik ENSMUST00000321424.1 1700024J04Rik (from geneSymbol) uc335qxw.1 uc335qxw.1 
ENSMUST00000321438.1 ENSMUSG00000133899 ENSMUST00000321438.1 ENSMUSG00000133899 (from geneSymbol) uc335qyk.1 uc335qyk.1 
ENSMUST00000321442.1 ENSMUSG00000133900 ENSMUST00000321442.1 ENSMUSG00000133900 (from geneSymbol) uc335qyo.1 uc335qyo.1 
ENSMUST00000321444.1 ENSMUSG00000133901 ENSMUST00000321444.1 ENSMUSG00000133901 (from geneSymbol) uc335qyq.1 uc335qyq.1 
ENSMUST00000321445.1 ENSMUSG00000133902 ENSMUST00000321445.1 ENSMUSG00000133902 (from geneSymbol) uc335qyr.1 uc335qyr.1 
ENSMUST00000321446.1 BC106179 ENSMUST00000321446.1 BC106179 (from geneSymbol) AK161755 uc335qys.1 uc335qys.1 
ENSMUST00000321448.1 Srrm4os ENSMUST00000321448.1 Srrm4os (from geneSymbol) AK082818 uc335qyu.1 uc335qyu.1 
ENSMUST00000321461.1 Gm36161 ENSMUST00000321461.1 Gm36161 (from geneSymbol) AK042295 uc335qzh.1 uc335qzh.1 
ENSMUST00000321484.1 ENSMUSG00000133903 ENSMUST00000321484.1 ENSMUSG00000133903 (from geneSymbol) uc335rae.1 uc335rae.1 
ENSMUST00000321490.1 ENSMUSG00000133904 ENSMUST00000321490.1 ENSMUSG00000133904 (from geneSymbol) uc335rak.1 uc335rak.1 
ENSMUST00000321492.1 ENSMUSG00000133905 ENSMUST00000321492.1 ENSMUSG00000133905 (from geneSymbol) uc335ram.1 uc335ram.1 
ENSMUST00000321497.1 ENSMUSG00000133906 ENSMUST00000321497.1 ENSMUSG00000133906 (from geneSymbol) uc335rar.1 uc335rar.1 
ENSMUST00000321502.1 6720483E21Rik ENSMUST00000321502.1 6720483E21Rik (from geneSymbol) AK020171 uc335raw.1 uc335raw.1 
ENSMUST00000321506.1 Gm15834 ENSMUST00000321506.1 predicted gene 15834, transcript variant 1 (from RefSeq NR_190137.1) NR_190137 uc335rba.1 uc335rba.1 
ENSMUST00000321510.1 Gm28351 ENSMUST00000321510.1 Gm28351 (from geneSymbol) uc335rbe.1 uc335rbe.1 
ENSMUST00000321512.1 ENSMUSG00000133907 ENSMUST00000321512.1 ENSMUSG00000133907 (from geneSymbol) uc335rbg.1 uc335rbg.1 
ENSMUST00000321514.1 ENSMUSG00000133908 ENSMUST00000321514.1 ENSMUSG00000133908 (from geneSymbol) uc335rbi.1 uc335rbi.1 
ENSMUST00000321515.1 ENSMUSG00000133909 ENSMUST00000321515.1 ENSMUSG00000133909 (from geneSymbol) uc335rbj.1 uc335rbj.1 
ENSMUST00000321516.1 Gm48529 ENSMUST00000321516.1 Gm48529 (from geneSymbol) uc335rbk.1 uc335rbk.1 
ENSMUST00000321518.1 ENSMUSG00000133910 ENSMUST00000321518.1 ENSMUSG00000133910 (from geneSymbol) uc335rbm.1 uc335rbm.1 
ENSMUST00000321524.1 ENSMUSG00000133911 ENSMUST00000321524.1 ENSMUSG00000133911 (from geneSymbol) uc335rbs.1 uc335rbs.1 
ENSMUST00000321529.1 ENSMUSG00000133912 ENSMUST00000321529.1 ENSMUSG00000133912 (from geneSymbol) uc335rbx.1 uc335rbx.1 
ENSMUST00000321532.1 ENSMUSG00000133913 ENSMUST00000321532.1 ENSMUSG00000133913 (from geneSymbol) uc335rca.1 uc335rca.1 
ENSMUST00000321533.1 Gm4610 ENSMUST00000321533.1 Gm4610 (from geneSymbol) uc335rcb.1 uc335rcb.1 
ENSMUST00000321534.1 Gm20703 ENSMUST00000321534.1 Gm20703 (from geneSymbol) uc335rcc.1 uc335rcc.1 
ENSMUST00000321539.1 ENSMUSG00000133914 ENSMUST00000321539.1 ENSMUSG00000133914 (from geneSymbol) uc335rch.1 uc335rch.1 
ENSMUST00000321541.1 ENSMUSG00000133915 ENSMUST00000321541.1 ENSMUSG00000133915 (from geneSymbol) uc335rcj.1 uc335rcj.1 
ENSMUST00000321542.1 ENSMUSG00000133916 ENSMUST00000321542.1 ENSMUSG00000133916 (from geneSymbol) uc335rck.1 uc335rck.1 
ENSMUST00000321546.1 Gm33086 ENSMUST00000321546.1 Gm33086 (from geneSymbol) uc335rco.1 uc335rco.1 
ENSMUST00000321549.1 ENSMUSG00000133917 ENSMUST00000321549.1 ENSMUSG00000133917 (from geneSymbol) uc335rcr.1 uc335rcr.1 
ENSMUST00000321550.1 ENSMUSG00000133918 ENSMUST00000321550.1 ENSMUSG00000133918 (from geneSymbol) uc335rcs.1 uc335rcs.1 
ENSMUST00000321552.1 ENSMUSG00000133919 ENSMUST00000321552.1 ENSMUSG00000133919 (from geneSymbol) uc335rcu.1 uc335rcu.1 
ENSMUST00000321561.1 ENSMUSG00000133920 ENSMUST00000321561.1 ENSMUSG00000133920 (from geneSymbol) uc335rdd.1 uc335rdd.1 
ENSMUST00000321563.1 ENSMUSG00000133921 ENSMUST00000321563.1 ENSMUSG00000133921 (from geneSymbol) uc335rdf.1 uc335rdf.1 
ENSMUST00000321580.1 ENSMUSG00000133922 ENSMUST00000321580.1 ENSMUSG00000133922 (from geneSymbol) uc335rdw.1 uc335rdw.1 
ENSMUST00000321600.1 ENSMUSG00000133923 ENSMUST00000321600.1 ENSMUSG00000133923 (from geneSymbol) uc335req.1 uc335req.1 
ENSMUST00000321602.1 ENSMUSG00000133924 ENSMUST00000321602.1 ENSMUSG00000133924 (from geneSymbol) uc335res.1 uc335res.1 
ENSMUST00000321603.1 ENSMUSG00000133925 ENSMUST00000321603.1 ENSMUSG00000133925 (from geneSymbol) uc335ret.1 uc335ret.1 
ENSMUST00000321604.1 ENSMUSG00000133926 ENSMUST00000321604.1 ENSMUSG00000133926 (from geneSymbol) uc335reu.1 uc335reu.1 
ENSMUST00000321613.1 ENSMUSG00000133927 ENSMUST00000321613.1 ENSMUSG00000133927 (from geneSymbol) LF197075 uc335rfd.1 uc335rfd.1 
ENSMUST00000321614.1 ENSMUSG00000133928 ENSMUST00000321614.1 ENSMUSG00000133928 (from geneSymbol) uc335rfe.1 uc335rfe.1 
ENSMUST00000321621.1 ENSMUSG00000133929 ENSMUST00000321621.1 ENSMUSG00000133929 (from geneSymbol) uc335rfl.1 uc335rfl.1 
ENSMUST00000321626.1 ENSMUSG00000133930 ENSMUST00000321626.1 ENSMUSG00000133930 (from geneSymbol) uc335rfq.1 uc335rfq.1 
ENSMUST00000321627.1 ENSMUSG00000133931 ENSMUST00000321627.1 ENSMUSG00000133931 (from geneSymbol) uc335rfr.1 uc335rfr.1 
ENSMUST00000321630.1 ENSMUSG00000133932 ENSMUST00000321630.1 ENSMUSG00000133932 (from geneSymbol) uc335rfu.1 uc335rfu.1 
ENSMUST00000321636.1 ENSMUSG00000133933 ENSMUST00000321636.1 ENSMUSG00000133933 (from geneSymbol) uc335rga.1 uc335rga.1 
ENSMUST00000321647.1 ENSMUSG00000133934 ENSMUST00000321647.1 ENSMUSG00000133934 (from geneSymbol) uc335rgl.1 uc335rgl.1 
ENSMUST00000321649.1 ENSMUSG00000133935 ENSMUST00000321649.1 ENSMUSG00000133935 (from geneSymbol) uc335rgn.1 uc335rgn.1 
ENSMUST00000321650.1 ENSMUSG00000133936 ENSMUST00000321650.1 ENSMUSG00000133936 (from geneSymbol) uc335rgo.1 uc335rgo.1 
ENSMUST00000321658.1 ENSMUSG00000133937 ENSMUST00000321658.1 ENSMUSG00000133937 (from geneSymbol) uc335rgu.1 uc335rgu.1 
ENSMUST00000321659.1 ENSMUSG00000133938 ENSMUST00000321659.1 ENSMUSG00000133938 (from geneSymbol) uc335rgv.1 uc335rgv.1 
ENSMUST00000321664.1 ENSMUSG00000133939 ENSMUST00000321664.1 ENSMUSG00000133939 (from geneSymbol) uc335rha.1 uc335rha.1 
ENSMUST00000321666.1 ENSMUSG00000133940 ENSMUST00000321666.1 ENSMUSG00000133940 (from geneSymbol) uc335rhc.1 uc335rhc.1 
ENSMUST00000321669.1 ENSMUSG00000133941 ENSMUST00000321669.1 ENSMUSG00000133941 (from geneSymbol) uc335rhf.1 uc335rhf.1 
ENSMUST00000321670.1 ENSMUSG00000133942 ENSMUST00000321670.1 ENSMUSG00000133942 (from geneSymbol) uc335rhg.1 uc335rhg.1 
ENSMUST00000321672.1 ENSMUSG00000133943 ENSMUST00000321672.1 ENSMUSG00000133943 (from geneSymbol) uc335rhi.1 uc335rhi.1 
ENSMUST00000321674.1 ENSMUSG00000133944 ENSMUST00000321674.1 ENSMUSG00000133944 (from geneSymbol) uc335rhk.1 uc335rhk.1 
ENSMUST00000321676.1 ENSMUSG00000133945 ENSMUST00000321676.1 ENSMUSG00000133945 (from geneSymbol) uc335rhm.1 uc335rhm.1 
ENSMUST00000321679.1 ENSMUSG00000133946 ENSMUST00000321679.1 ENSMUSG00000133946 (from geneSymbol) uc335rhp.1 uc335rhp.1 
ENSMUST00000321680.1 ENSMUSG00000133947 ENSMUST00000321680.1 ENSMUSG00000133947 (from geneSymbol) uc335rhq.1 uc335rhq.1 
ENSMUST00000321692.1 Gm10373 ENSMUST00000321692.1 Gm10373 (from geneSymbol) AK148391 uc335rib.1 uc335rib.1 
ENSMUST00000321716.1 ENSMUSG00000133949 ENSMUST00000321716.1 ENSMUSG00000133949 (from geneSymbol) uc335riz.1 uc335riz.1 
ENSMUST00000321717.1 ENSMUSG00000133950 ENSMUST00000321717.1 ENSMUSG00000133950 (from geneSymbol) uc335rja.1 uc335rja.1 
ENSMUST00000321727.1 ENSMUSG00000133951 ENSMUST00000321727.1 ENSMUSG00000133951 (from geneSymbol) uc335rjk.1 uc335rjk.1 
ENSMUST00000321731.1 ENSMUSG00000133952 ENSMUST00000321731.1 ENSMUSG00000133952 (from geneSymbol) uc335rjo.1 uc335rjo.1 
ENSMUST00000321732.1 ENSMUSG00000133953 ENSMUST00000321732.1 ENSMUSG00000133953 (from geneSymbol) uc335rjp.1 uc335rjp.1 
ENSMUST00000321733.1 ENSMUSG00000133954 ENSMUST00000321733.1 ENSMUSG00000133954 (from geneSymbol) uc335rjq.1 uc335rjq.1 
ENSMUST00000321749.1 ENSMUSG00000133955 ENSMUST00000321749.1 ENSMUSG00000133955 (from geneSymbol) uc335rkg.1 uc335rkg.1 
ENSMUST00000321754.1 ENSMUSG00000133956 ENSMUST00000321754.1 ENSMUSG00000133956 (from geneSymbol) uc335rkl.1 uc335rkl.1 
ENSMUST00000321758.1 ENSMUSG00000133957 ENSMUST00000321758.1 ENSMUSG00000133957 (from geneSymbol) uc335rkp.1 uc335rkp.1 
ENSMUST00000321759.1 ENSMUSG00000133958 ENSMUST00000321759.1 ENSMUSG00000133958 (from geneSymbol) uc335rkq.1 uc335rkq.1 
ENSMUST00000321762.1 ENSMUSG00000133959 ENSMUST00000321762.1 ENSMUSG00000133959 (from geneSymbol) uc335rkt.1 uc335rkt.1 
ENSMUST00000321766.1 ENSMUSG00000133960 ENSMUST00000321766.1 ENSMUSG00000133960 (from geneSymbol) uc335rkx.1 uc335rkx.1 
ENSMUST00000321767.1 ENSMUSG00000133961 ENSMUST00000321767.1 ENSMUSG00000133961 (from geneSymbol) uc335rky.1 uc335rky.1 
ENSMUST00000321770.1 ENSMUSG00000133963 ENSMUST00000321770.1 ENSMUSG00000133963 (from geneSymbol) uc335rla.1 uc335rla.1 
ENSMUST00000321772.1 ENSMUSG00000133964 ENSMUST00000321772.1 ENSMUSG00000133964 (from geneSymbol) uc335rlc.1 uc335rlc.1 
ENSMUST00000321774.1 ENSMUSG00000133965 ENSMUST00000321774.1 ENSMUSG00000133965 (from geneSymbol) uc335rle.1 uc335rle.1 
ENSMUST00000321775.1 ENSMUSG00000133966 ENSMUST00000321775.1 ENSMUSG00000133966 (from geneSymbol) uc335rlf.1 uc335rlf.1 
ENSMUST00000321776.1 ENSMUSG00000133967 ENSMUST00000321776.1 ENSMUSG00000133967 (from geneSymbol) uc335rlg.1 uc335rlg.1 
ENSMUST00000321777.1 ENSMUSG00000133968 ENSMUST00000321777.1 ENSMUSG00000133968 (from geneSymbol) uc335rlh.1 uc335rlh.1 
ENSMUST00000321781.1 ENSMUSG00000133969 ENSMUST00000321781.1 ENSMUSG00000133969 (from geneSymbol) uc335rll.1 uc335rll.1 
ENSMUST00000321785.1 ENSMUSG00000133970 ENSMUST00000321785.1 ENSMUSG00000133970 (from geneSymbol) AK007243 uc335rlp.1 uc335rlp.1 
ENSMUST00000321787.1 ENSMUSG00000133971 ENSMUST00000321787.1 ENSMUSG00000133971 (from geneSymbol) uc335rlr.1 uc335rlr.1 
ENSMUST00000321789.1 ENSMUSG00000133972 ENSMUST00000321789.1 ENSMUSG00000133972 (from geneSymbol) uc335rlt.1 uc335rlt.1 
ENSMUST00000321791.1 ENSMUSG00000133973 ENSMUST00000321791.1 ENSMUSG00000133973 (from geneSymbol) uc335rlv.1 uc335rlv.1 
ENSMUST00000321792.1 ENSMUSG00000133974 ENSMUST00000321792.1 ENSMUSG00000133974 (from geneSymbol) uc335rlw.1 uc335rlw.1 
ENSMUST00000321797.1 Gm28564 ENSMUST00000321797.1 Gm28564 (from geneSymbol) AK135068 uc335rmb.1 uc335rmb.1 
ENSMUST00000321821.1 4930542C12Rik ENSMUST00000321821.1 4930542C12Rik (from geneSymbol) uc335rmu.1 uc335rmu.1 
ENSMUST00000321822.1 ENSMUSG00000133976 ENSMUST00000321822.1 ENSMUSG00000133976 (from geneSymbol) uc335rmv.1 uc335rmv.1 
ENSMUST00000321823.1 ENSMUSG00000133977 ENSMUST00000321823.1 ENSMUSG00000133977 (from geneSymbol) uc335rmw.1 uc335rmw.1 
ENSMUST00000321825.1 ENSMUSG00000133978 ENSMUST00000321825.1 ENSMUSG00000133978 (from geneSymbol) uc335rmy.1 uc335rmy.1 
ENSMUST00000321826.1 ENSMUSG00000133979 ENSMUST00000321826.1 ENSMUSG00000133979 (from geneSymbol) uc335rmz.1 uc335rmz.1 
ENSMUST00000321827.1 4930562A09Rik ENSMUST00000321827.1 4930562A09Rik (from geneSymbol) AK016187 uc335rna.1 uc335rna.1 
ENSMUST00000321834.1 ENSMUSG00000133980 ENSMUST00000321834.1 ENSMUSG00000133980 (from geneSymbol) uc335rnh.1 uc335rnh.1 
ENSMUST00000321835.1 ENSMUSG00000133981 ENSMUST00000321835.1 ENSMUSG00000133981 (from geneSymbol) uc335rni.1 uc335rni.1 
ENSMUST00000321836.1 ENSMUSG00000133982 ENSMUST00000321836.1 ENSMUSG00000133982 (from geneSymbol) uc335rnj.1 uc335rnj.1 
ENSMUST00000321837.1 ENSMUSG00000133983 ENSMUST00000321837.1 ENSMUSG00000133983 (from geneSymbol) uc335rnk.1 uc335rnk.1 
ENSMUST00000321839.1 ENSMUSG00000133984 ENSMUST00000321839.1 ENSMUSG00000133984 (from geneSymbol) uc335rnm.1 uc335rnm.1 
ENSMUST00000321840.1 ENSMUSG00000133985 ENSMUST00000321840.1 RIKEN cDNA 4930465K10 gene (from RefSeq NR_027978.1) NR_027978 uc335rnn.1 uc335rnn.1 
ENSMUST00000321843.1 ENSMUSG00000133986 ENSMUST00000321843.1 ENSMUSG00000133986 (from geneSymbol) uc335rnq.1 uc335rnq.1 
ENSMUST00000321844.1 ENSMUSG00000133987 ENSMUST00000321844.1 ENSMUSG00000133987 (from geneSymbol) uc335rnr.1 uc335rnr.1 
ENSMUST00000321847.1 ENSMUSG00000133988 ENSMUST00000321847.1 ENSMUSG00000133988 (from geneSymbol) uc335rnu.1 uc335rnu.1 
ENSMUST00000321852.1 ENSMUSG00000133989 ENSMUST00000321852.1 ENSMUSG00000133989 (from geneSymbol) uc335rnz.1 uc335rnz.1 
ENSMUST00000321854.1 ENSMUSG00000133990 ENSMUST00000321854.1 ENSMUSG00000133990 (from geneSymbol) uc335rob.1 uc335rob.1 
ENSMUST00000321859.1 ENSMUSG00000133991 ENSMUST00000321859.1 ENSMUSG00000133991 (from geneSymbol) uc335rog.1 uc335rog.1 
ENSMUST00000321862.1 ENSMUSG00000133992 ENSMUST00000321862.1 ENSMUSG00000133992 (from geneSymbol) uc335roj.1 uc335roj.1 
ENSMUST00000321863.1 ENSMUSG00000133993 ENSMUST00000321863.1 ENSMUSG00000133993 (from geneSymbol) uc335rok.1 uc335rok.1 
ENSMUST00000321867.1 ENSMUSG00000133994 ENSMUST00000321867.1 ENSMUSG00000133994 (from geneSymbol) uc335roo.1 uc335roo.1 
ENSMUST00000321875.1 ENSMUSG00000133995 ENSMUST00000321875.1 ENSMUSG00000133995 (from geneSymbol) uc335row.1 uc335row.1 
ENSMUST00000321876.1 ENSMUSG00000133996 ENSMUST00000321876.1 ENSMUSG00000133996 (from geneSymbol) uc335rox.1 uc335rox.1 
ENSMUST00000321882.1 ENSMUSG00000133997 ENSMUST00000321882.1 ENSMUSG00000133997 (from geneSymbol) uc335rpd.1 uc335rpd.1 
ENSMUST00000321884.1 Gm14541 ENSMUST00000321884.1 predicted gene 14541 (from RefSeq NR_165298.1) NR_165298 uc335rpf.1 uc335rpf.1 
ENSMUST00000321885.1 ENSMUSG00000133999 ENSMUST00000321885.1 ENSMUSG00000133999 (from geneSymbol) uc335rpg.1 uc335rpg.1 
ENSMUST00000321886.1 ENSMUSG00000134000 ENSMUST00000321886.1 ENSMUSG00000134000 (from geneSymbol) uc335rph.1 uc335rph.1 
ENSMUST00000321887.1 ENSMUSG00000134001 ENSMUST00000321887.1 ENSMUSG00000134001 (from geneSymbol) uc335rpi.1 uc335rpi.1 
ENSMUST00000321890.1 ENSMUSG00000134002 ENSMUST00000321890.1 ENSMUSG00000134002 (from geneSymbol) uc335rpl.1 uc335rpl.1 
ENSMUST00000321895.1 Gm49008 ENSMUST00000321895.1 Gm49008 (from geneSymbol) uc335rpq.1 uc335rpq.1 
ENSMUST00000321899.1 ENSMUSG00000134003 ENSMUST00000321899.1 ENSMUSG00000134003 (from geneSymbol) uc335rpu.1 uc335rpu.1 
ENSMUST00000321901.1 Gm11468 ENSMUST00000321901.1 Gm11468 (from geneSymbol) uc335rpw.1 uc335rpw.1 
ENSMUST00000321908.1 ENSMUSG00000134004 ENSMUST00000321908.1 ENSMUSG00000134004 (from geneSymbol) uc335rqd.1 uc335rqd.1 
ENSMUST00000321909.1 ENSMUSG00000134005 ENSMUST00000321909.1 ENSMUSG00000134005 (from geneSymbol) uc335rqe.1 uc335rqe.1 
ENSMUST00000321918.1 ENSMUSG00000134006 ENSMUST00000321918.1 ENSMUSG00000134006 (from geneSymbol) uc335rqn.1 uc335rqn.1 
ENSMUST00000321919.1 ENSMUSG00000134007 ENSMUST00000321919.1 ENSMUSG00000134007 (from geneSymbol) uc335rqo.1 uc335rqo.1 
ENSMUST00000321920.1 Gm34263 ENSMUST00000321920.1 Gm34263 (from geneSymbol) uc335rqp.1 uc335rqp.1 
ENSMUST00000321938.1 ENSMUSG00000134008 ENSMUST00000321938.1 ENSMUSG00000134008 (from geneSymbol) uc335rrh.1 uc335rrh.1 
ENSMUST00000321941.1 ENSMUSG00000134009 ENSMUST00000321941.1 ENSMUSG00000134009 (from geneSymbol) AK051120 uc335rrk.1 uc335rrk.1 
ENSMUST00000321942.1 ENSMUSG00000134010 ENSMUST00000321942.1 ENSMUSG00000134010 (from geneSymbol) uc335rrl.1 uc335rrl.1 
ENSMUST00000321943.1 ENSMUSG00000134011 ENSMUST00000321943.1 ENSMUSG00000134011 (from geneSymbol) uc335rrm.1 uc335rrm.1 
ENSMUST00000321944.1 ENSMUSG00000134012 ENSMUST00000321944.1 ENSMUSG00000134012 (from geneSymbol) uc335rrn.1 uc335rrn.1 
ENSMUST00000321945.1 ENSMUSG00000134013 ENSMUST00000321945.1 ENSMUSG00000134013 (from geneSymbol) uc335rro.1 uc335rro.1 
ENSMUST00000321947.1 ENSMUSG00000134014 ENSMUST00000321947.1 ENSMUSG00000134014 (from geneSymbol) uc335rrq.1 uc335rrq.1 
ENSMUST00000321949.1 ENSMUSG00000134015 ENSMUST00000321949.1 ENSMUSG00000134015 (from geneSymbol) uc335rrs.1 uc335rrs.1 
ENSMUST00000321950.1 1700034H15Rik ENSMUST00000321950.1 1700034H15Rik (from geneSymbol) uc335rrt.1 uc335rrt.1 
ENSMUST00000322009.1 ENSMUSG00000134016 ENSMUST00000322009.1 ENSMUSG00000134016 (from geneSymbol) uc335rua.1 uc335rua.1 
ENSMUST00000322010.1 1700061E18Rik ENSMUST00000322010.1 1700061E18Rik (from geneSymbol) AK006851 uc335rub.1 uc335rub.1 
ENSMUST00000322035.1 0610009E02Rik ENSMUST00000322035.1 0610009E02Rik (from geneSymbol) AK075572 uc335rva.1 uc335rva.1 
ENSMUST00000322069.1 Gm10440 ENSMUST00000322069.1 Gm10440 (from geneSymbol) AK051685 uc335rwi.1 uc335rwi.1 
ENSMUST00000322088.1 ENSMUSG00000134017 ENSMUST00000322088.1 ENSMUSG00000134017 (from geneSymbol) uc335rxb.1 uc335rxb.1 
ENSMUST00000322091.1 ENSMUSG00000134018 ENSMUST00000322091.1 ENSMUSG00000134018 (from geneSymbol) uc335rxe.1 uc335rxe.1 
ENSMUST00000322093.1 ENSMUSG00000134019 ENSMUST00000322093.1 ENSMUSG00000134019 (from geneSymbol) uc335rxg.1 uc335rxg.1 
ENSMUST00000322094.1 ENSMUSG00000134020 ENSMUST00000322094.1 ENSMUSG00000134020 (from geneSymbol) uc335rxh.1 uc335rxh.1 
ENSMUST00000322097.1 ENSMUSG00000134021 ENSMUST00000322097.1 ENSMUSG00000134021 (from geneSymbol) uc335rxk.1 uc335rxk.1 
ENSMUST00000322098.1 ENSMUSG00000134022 ENSMUST00000322098.1 ENSMUSG00000134022 (from geneSymbol) uc335rxl.1 uc335rxl.1 
ENSMUST00000322099.1 ENSMUSG00000134023 ENSMUST00000322099.1 ENSMUSG00000134023 (from geneSymbol) uc335rxm.1 uc335rxm.1 
ENSMUST00000322100.1 ENSMUSG00000134024 ENSMUST00000322100.1 ENSMUSG00000134024 (from geneSymbol) uc335rxn.1 uc335rxn.1 
ENSMUST00000322103.1 ENSMUSG00000134025 ENSMUST00000322103.1 ENSMUSG00000134025 (from geneSymbol) uc335rxq.1 uc335rxq.1 
ENSMUST00000322104.1 ENSMUSG00000134026 ENSMUST00000322104.1 ENSMUSG00000134026 (from geneSymbol) uc335rxr.1 uc335rxr.1 
ENSMUST00000322107.1 ENSMUSG00000134027 ENSMUST00000322107.1 ENSMUSG00000134027 (from geneSymbol) uc335rxu.1 uc335rxu.1 
ENSMUST00000322109.1 ENSMUSG00000134028 ENSMUST00000322109.1 ENSMUSG00000134028 (from geneSymbol) uc335rxw.1 uc335rxw.1 
ENSMUST00000322130.1 ENSMUSG00000134029 ENSMUST00000322130.1 ENSMUSG00000134029 (from geneSymbol) uc335ryr.1 uc335ryr.1 
ENSMUST00000322133.1 ENSMUSG00000134030 ENSMUST00000322133.1 ENSMUSG00000134030 (from geneSymbol) uc335ryu.1 uc335ryu.1 
ENSMUST00000322139.1 ENSMUSG00000134031 ENSMUST00000322139.1 ENSMUSG00000134031 (from geneSymbol) uc335rza.1 uc335rza.1 
ENSMUST00000322141.1 ENSMUSG00000134032 ENSMUST00000322141.1 ENSMUSG00000134032 (from geneSymbol) uc335rzc.1 uc335rzc.1 
ENSMUST00000322143.1 1700127F24Rik ENSMUST00000322143.1 1700127F24Rik (from geneSymbol) uc335rze.1 uc335rze.1 
ENSMUST00000322168.1 ENSMUSG00000134033 ENSMUST00000322168.1 ENSMUSG00000134033 (from geneSymbol) uc335sad.1 uc335sad.1 
ENSMUST00000322171.1 ENSMUSG00000134034 ENSMUST00000322171.1 ENSMUSG00000134034 (from geneSymbol) uc335sag.1 uc335sag.1 
ENSMUST00000322172.1 ENSMUSG00000134035 ENSMUST00000322172.1 ENSMUSG00000134035 (from geneSymbol) uc335sah.1 uc335sah.1 
ENSMUST00000322174.1 ENSMUSG00000134036 ENSMUST00000322174.1 ENSMUSG00000134036 (from geneSymbol) uc335saj.1 uc335saj.1 
ENSMUST00000322176.1 ENSMUSG00000134037 ENSMUST00000322176.1 ENSMUSG00000134037 (from geneSymbol) uc335sal.1 uc335sal.1 
ENSMUST00000322179.1 ENSMUSG00000134038 ENSMUST00000322179.1 ENSMUSG00000134038 (from geneSymbol) AK131784 uc335sao.1 uc335sao.1 
ENSMUST00000322183.1 ENSMUSG00000134039 ENSMUST00000322183.1 ENSMUSG00000134039 (from geneSymbol) uc335sas.1 uc335sas.1 
ENSMUST00000322190.1 ENSMUSG00000134040 ENSMUST00000322190.1 ENSMUSG00000134040 (from geneSymbol) uc335saz.1 uc335saz.1 
ENSMUST00000322191.1 ENSMUSG00000134041 ENSMUST00000322191.1 ENSMUSG00000134041 (from geneSymbol) uc335sba.1 uc335sba.1 
ENSMUST00000322194.1 Gm33831 ENSMUST00000322194.1 Gm33831 (from geneSymbol) uc335sbc.1 uc335sbc.1 
ENSMUST00000322196.1 1700110C19Rik ENSMUST00000322196.1 1700110C19Rik (from geneSymbol) AK007157 uc335sbe.1 uc335sbe.1 
ENSMUST00000322201.1 ENSMUSG00000134043 ENSMUST00000322201.1 ENSMUSG00000134043 (from geneSymbol) uc335sbj.1 uc335sbj.1 
ENSMUST00000322216.1 ENSMUSG00000134044 ENSMUST00000322216.1 ENSMUSG00000134044 (from geneSymbol) AF357361 uc335sbx.1 uc335sbx.1 
ENSMUST00000322217.1 ENSMUSG00000134045 ENSMUST00000322217.1 ENSMUSG00000134045 (from geneSymbol) uc335sby.1 uc335sby.1 
ENSMUST00000322218.1 ENSMUSG00000134046 ENSMUST00000322218.1 ENSMUSG00000134046 (from geneSymbol) uc335sbz.1 uc335sbz.1 
ENSMUST00000322219.1 ENSMUSG00000134047 ENSMUST00000322219.1 ENSMUSG00000134047 (from geneSymbol) uc335sca.1 uc335sca.1 
ENSMUST00000322220.1 ENSMUSG00000134048 ENSMUST00000322220.1 ENSMUSG00000134048 (from geneSymbol) uc335scb.1 uc335scb.1 
ENSMUST00000322221.1 ENSMUSG00000134049 ENSMUST00000322221.1 ENSMUSG00000134049 (from geneSymbol) uc335scc.1 uc335scc.1 
ENSMUST00000322223.1 ENSMUSG00000134051 ENSMUST00000322223.1 ENSMUSG00000134051 (from geneSymbol) uc335scd.1 uc335scd.1 
ENSMUST00000322225.1 ENSMUSG00000134052 ENSMUST00000322225.1 ENSMUSG00000134052 (from geneSymbol) uc335scf.1 uc335scf.1 
ENSMUST00000322228.1 4930546K05Rik ENSMUST00000322228.1 4930546K05Rik (from geneSymbol) AK133167 uc335sci.1 uc335sci.1 
ENSMUST00000322232.1 ENSMUSG00000134053 ENSMUST00000322232.1 ENSMUSG00000134053 (from geneSymbol) uc335scm.1 uc335scm.1 
ENSMUST00000322233.1 ENSMUSG00000134054 ENSMUST00000322233.1 ENSMUSG00000134054 (from geneSymbol) uc335scn.1 uc335scn.1 
ENSMUST00000322236.1 ENSMUSG00000134055 ENSMUST00000322236.1 ENSMUSG00000134055 (from geneSymbol) uc335scq.1 uc335scq.1 
ENSMUST00000322237.1 ENSMUSG00000134057 ENSMUST00000322237.1 ENSMUSG00000134057 (from geneSymbol) uc335scr.1 uc335scr.1 
ENSMUST00000322240.1 ENSMUSG00000134058 ENSMUST00000322240.1 ENSMUSG00000134058 (from geneSymbol) uc335sct.1 uc335sct.1 
ENSMUST00000322241.1 ENSMUSG00000134059 ENSMUST00000322241.1 ENSMUSG00000134059 (from geneSymbol) uc335scu.1 uc335scu.1 
ENSMUST00000322262.1 ENSMUSG00000134060 ENSMUST00000322262.1 ENSMUSG00000134060 (from geneSymbol) uc335sdp.1 uc335sdp.1 
ENSMUST00000322263.1 ENSMUSG00000134061 ENSMUST00000322263.1 ENSMUSG00000134061 (from geneSymbol) uc335sdq.1 uc335sdq.1 
ENSMUST00000322266.1 Gm33586 ENSMUST00000322266.1 Gm33586 (from geneSymbol) BC042407 uc335sdt.1 uc335sdt.1 
ENSMUST00000322278.1 ENSMUSG00000134062 ENSMUST00000322278.1 ENSMUSG00000134062 (from geneSymbol) uc335sef.1 uc335sef.1 
ENSMUST00000322280.1 ENSMUSG00000134063 ENSMUST00000322280.1 ENSMUSG00000134063 (from geneSymbol) uc335seh.1 uc335seh.1 
ENSMUST00000322282.1 ENSMUSG00000134064 ENSMUST00000322282.1 ENSMUSG00000134064 (from geneSymbol) uc335sej.1 uc335sej.1 
ENSMUST00000322285.1 ENSMUSG00000134065 ENSMUST00000322285.1 ENSMUSG00000134065 (from geneSymbol) uc335sem.1 uc335sem.1 
ENSMUST00000322286.1 ENSMUSG00000134066 ENSMUST00000322286.1 ENSMUSG00000134066 (from geneSymbol) uc335sen.1 uc335sen.1 
ENSMUST00000322287.1 ENSMUSG00000134067 ENSMUST00000322287.1 ENSMUSG00000134067 (from geneSymbol) uc335seo.1 uc335seo.1 
ENSMUST00000322288.1 ENSMUSG00000134068 ENSMUST00000322288.1 ENSMUSG00000134068 (from geneSymbol) uc335sep.1 uc335sep.1 
ENSMUST00000322291.1 ENSMUSG00000134069 ENSMUST00000322291.1 ENSMUSG00000134069 (from geneSymbol) uc335ses.1 uc335ses.1 
ENSMUST00000322293.1 ENSMUSG00000134070 ENSMUST00000322293.1 ENSMUSG00000134070 (from geneSymbol) uc335seu.1 uc335seu.1 
ENSMUST00000322295.1 ENSMUSG00000134071 ENSMUST00000322295.1 ENSMUSG00000134071 (from geneSymbol) uc335sew.1 uc335sew.1 
ENSMUST00000322320.1 ENSMUSG00000134072 ENSMUST00000322320.1 ENSMUSG00000134072 (from geneSymbol) uc335sfv.1 uc335sfv.1 
ENSMUST00000322321.1 ENSMUSG00000134073 ENSMUST00000322321.1 ENSMUSG00000134073 (from geneSymbol) uc335sfw.1 uc335sfw.1 
ENSMUST00000322322.1 ENSMUSG00000134074 ENSMUST00000322322.1 ENSMUSG00000134074 (from geneSymbol) uc335sfx.1 uc335sfx.1 
ENSMUST00000322329.1 ENSMUSG00000134075 ENSMUST00000322329.1 ENSMUSG00000134075 (from geneSymbol) uc335sge.1 uc335sge.1 
ENSMUST00000322332.1 ENSMUSG00000134076 ENSMUST00000322332.1 ENSMUSG00000134076 (from geneSymbol) uc335sgh.1 uc335sgh.1 
ENSMUST00000322334.1 ENSMUSG00000134077 ENSMUST00000322334.1 ENSMUSG00000134077 (from geneSymbol) uc335sgj.1 uc335sgj.1 
ENSMUST00000322340.1 ENSMUSG00000134078 ENSMUST00000322340.1 ENSMUSG00000134078 (from geneSymbol) uc335sgp.1 uc335sgp.1 
ENSMUST00000322349.1 ENSMUSG00000134079 ENSMUST00000322349.1 ENSMUSG00000134079 (from geneSymbol) uc335sgy.1 uc335sgy.1 
ENSMUST00000322351.1 ENSMUSG00000134080 ENSMUST00000322351.1 ENSMUSG00000134080 (from geneSymbol) uc335sha.1 uc335sha.1 
ENSMUST00000322376.1 ENSMUSG00000134081 ENSMUST00000322376.1 uncharacterized LOC105246046 (from RefSeq NR_155446.1) NR_155446 uc335shy.1 uc335shy.1 
ENSMUST00000322378.1 ENSMUSG00000134082 ENSMUST00000322378.1 ENSMUSG00000134082 (from geneSymbol) uc335sia.1 uc335sia.1 
ENSMUST00000322380.1 ENSMUSG00000134083 ENSMUST00000322380.1 ENSMUSG00000134083 (from geneSymbol) uc335sic.1 uc335sic.1 
ENSMUST00000322381.1 Gm28874 ENSMUST00000322381.1 Gm28874 (from geneSymbol) uc335sid.1 uc335sid.1 
ENSMUST00000322385.1 ENSMUSG00000134084 ENSMUST00000322385.1 ENSMUSG00000134084 (from geneSymbol) uc335sih.1 uc335sih.1 
ENSMUST00000322392.1 ENSMUSG00000134085 ENSMUST00000322392.1 ENSMUSG00000134085 (from geneSymbol) uc335sio.1 uc335sio.1 
ENSMUST00000322395.1 ENSMUSG00000134086 ENSMUST00000322395.1 ENSMUSG00000134086 (from geneSymbol) uc335sir.1 uc335sir.1 
ENSMUST00000322397.1 ENSMUSG00000134087 ENSMUST00000322397.1 ENSMUSG00000134087 (from geneSymbol) uc335sit.1 uc335sit.1 
ENSMUST00000322404.1 1700120G07Rik ENSMUST00000322404.1 1700120G07Rik (from geneSymbol) AK007216 uc335sja.1 uc335sja.1 
ENSMUST00000322426.1 ENSMUSG00000134088 ENSMUST00000322426.1 ENSMUSG00000134088 (from geneSymbol) LF197977 uc335sjw.1 uc335sjw.1 
ENSMUST00000322430.1 ENSMUSG00000134089 ENSMUST00000322430.1 ENSMUSG00000134089 (from geneSymbol) uc335ska.1 uc335ska.1 
ENSMUST00000322434.1 ENSMUSG00000134090 ENSMUST00000322434.1 ENSMUSG00000134090 (from geneSymbol) uc335ske.1 uc335ske.1 
ENSMUST00000322439.1 ENSMUSG00000134091 ENSMUST00000322439.1 ENSMUSG00000134091 (from geneSymbol) uc335skj.1 uc335skj.1 
ENSMUST00000322443.1 ENSMUSG00000134092 ENSMUST00000322443.1 ENSMUSG00000134092 (from geneSymbol) uc335skn.1 uc335skn.1 
ENSMUST00000322444.1 ENSMUSG00000134093 ENSMUST00000322444.1 ENSMUSG00000134093 (from geneSymbol) uc335sko.1 uc335sko.1 
ENSMUST00000322445.1 ENSMUSG00000134094 ENSMUST00000322445.1 ENSMUSG00000134094 (from geneSymbol) uc335skp.1 uc335skp.1 
ENSMUST00000322446.1 ENSMUSG00000134095 ENSMUST00000322446.1 ENSMUSG00000134095 (from geneSymbol) uc335skq.1 uc335skq.1 
ENSMUST00000322447.1 ENSMUSG00000134096 ENSMUST00000322447.1 ENSMUSG00000134096 (from geneSymbol) uc335skr.1 uc335skr.1 
ENSMUST00000322448.1 ENSMUSG00000134097 ENSMUST00000322448.1 ENSMUSG00000134097 (from geneSymbol) uc335sks.1 uc335sks.1 
ENSMUST00000322449.1 ENSMUSG00000134098 ENSMUST00000322449.1 ENSMUSG00000134098 (from geneSymbol) uc335skt.1 uc335skt.1 
ENSMUST00000322471.1 ENSMUSG00000134099 ENSMUST00000322471.1 ENSMUSG00000134099 (from geneSymbol) uc335slp.1 uc335slp.1 
ENSMUST00000322472.1 ENSMUSG00000134100 ENSMUST00000322472.1 ENSMUSG00000134100 (from geneSymbol) uc335slq.1 uc335slq.1 
ENSMUST00000322473.1 ENSMUSG00000134101 ENSMUST00000322473.1 ENSMUSG00000134101 (from geneSymbol) uc335slr.1 uc335slr.1 
ENSMUST00000322474.1 ENSMUSG00000134102 ENSMUST00000322474.1 ENSMUSG00000134102 (from geneSymbol) uc335sls.1 uc335sls.1 
ENSMUST00000322476.1 ENSMUSG00000134103 ENSMUST00000322476.1 ENSMUSG00000134103 (from geneSymbol) uc335slu.1 uc335slu.1 
ENSMUST00000322478.1 ENSMUSG00000134104 ENSMUST00000322478.1 ENSMUSG00000134104 (from geneSymbol) uc335slw.1 uc335slw.1 
ENSMUST00000322480.1 ENSMUSG00000134105 ENSMUST00000322480.1 ENSMUSG00000134105 (from geneSymbol) uc335sly.1 uc335sly.1 
ENSMUST00000322481.1 ENSMUSG00000134106 ENSMUST00000322481.1 ENSMUSG00000134106 (from geneSymbol) uc335slz.1 uc335slz.1 
ENSMUST00000322482.1 ENSMUSG00000134107 ENSMUST00000322482.1 ENSMUSG00000134107 (from geneSymbol) uc335sma.1 uc335sma.1 
ENSMUST00000322486.1 ENSMUSG00000134108 ENSMUST00000322486.1 ENSMUSG00000134108 (from geneSymbol) uc335sme.1 uc335sme.1 
ENSMUST00000322488.1 ENSMUSG00000134109 ENSMUST00000322488.1 ENSMUSG00000134109 (from geneSymbol) uc335smg.1 uc335smg.1 
ENSMUST00000322489.1 ENSMUSG00000134110 ENSMUST00000322489.1 ENSMUSG00000134110 (from geneSymbol) uc335smh.1 uc335smh.1 
ENSMUST00000322491.1 ENSMUSG00000134111 ENSMUST00000322491.1 ENSMUSG00000134111 (from geneSymbol) uc335smj.1 uc335smj.1 
ENSMUST00000322492.1 ENSMUSG00000134112 ENSMUST00000322492.1 ENSMUSG00000134112 (from geneSymbol) uc335smk.1 uc335smk.1 
ENSMUST00000322493.1 ENSMUSG00000134113 ENSMUST00000322493.1 ENSMUSG00000134113 (from geneSymbol) uc335sml.1 uc335sml.1 
ENSMUST00000322495.1 ENSMUSG00000134114 ENSMUST00000322495.1 ENSMUSG00000134114 (from geneSymbol) uc335smn.1 uc335smn.1 
ENSMUST00000322496.1 ENSMUSG00000134115 ENSMUST00000322496.1 ENSMUSG00000134115 (from geneSymbol) uc335smo.1 uc335smo.1 
ENSMUST00000322499.1 ENSMUSG00000134116 ENSMUST00000322499.1 ENSMUSG00000134116 (from geneSymbol) uc335smr.1 uc335smr.1 
ENSMUST00000322500.1 ENSMUSG00000134117 ENSMUST00000322500.1 ENSMUSG00000134117 (from geneSymbol) uc335sms.1 uc335sms.1 
ENSMUST00000322501.1 ENSMUSG00000134118 ENSMUST00000322501.1 ENSMUSG00000134118 (from geneSymbol) uc335smt.1 uc335smt.1 
ENSMUST00000322502.1 4930547E08Rik ENSMUST00000322502.1 4930547E08Rik (from geneSymbol) AK019749 uc335smu.1 uc335smu.1 
ENSMUST00000322505.1 ENSMUSG00000134119 ENSMUST00000322505.1 ENSMUSG00000134119 (from geneSymbol) uc335smx.1 uc335smx.1 
ENSMUST00000322506.1 Gm15491 ENSMUST00000322506.1 Gm15491 (from geneSymbol) AK040197 uc335smy.1 uc335smy.1 
ENSMUST00000322508.1 ENSMUSG00000134120 ENSMUST00000322508.1 ENSMUSG00000134120 (from geneSymbol) uc335sna.1 uc335sna.1 
ENSMUST00000322537.1 ENSMUSG00000134121 ENSMUST00000322537.1 ENSMUSG00000134121 (from geneSymbol) uc335sod.1 uc335sod.1 
ENSMUST00000322541.1 ENSMUSG00000134122 ENSMUST00000322541.1 ENSMUSG00000134122 (from geneSymbol) uc335soh.1 uc335soh.1 
ENSMUST00000322543.1 ENSMUSG00000134123 ENSMUST00000322543.1 ENSMUSG00000134123 (from geneSymbol) uc335soj.1 uc335soj.1 
ENSMUST00000322549.1 ENSMUSG00000134124 ENSMUST00000322549.1 ENSMUSG00000134124 (from geneSymbol) uc335sop.1 uc335sop.1 
ENSMUST00000322553.1 Gm34312 ENSMUST00000322553.1 Gm34312 (from geneSymbol) uc335sot.1 uc335sot.1 
ENSMUST00000322562.1 ENSMUSG00000134125 ENSMUST00000322562.1 ENSMUSG00000134125 (from geneSymbol) uc335spc.1 uc335spc.1 
ENSMUST00000322563.1 ENSMUSG00000134126 ENSMUST00000322563.1 ENSMUSG00000134126 (from geneSymbol) uc335spd.1 uc335spd.1 
ENSMUST00000322564.1 ENSMUSG00000134127 ENSMUST00000322564.1 ENSMUSG00000134127 (from geneSymbol) uc335spe.1 uc335spe.1 
ENSMUST00000322565.1 ENSMUSG00000134128 ENSMUST00000322565.1 ENSMUSG00000134128 (from geneSymbol) uc335spf.1 uc335spf.1 
ENSMUST00000322570.1 ENSMUSG00000134129 ENSMUST00000322570.1 ENSMUSG00000134129 (from geneSymbol) uc335spk.1 uc335spk.1 
ENSMUST00000322591.1 ENSMUSG00000134130 ENSMUST00000322591.1 ENSMUSG00000134130 (from geneSymbol) uc335sqf.1 uc335sqf.1 
ENSMUST00000322601.1 ENSMUSG00000134131 ENSMUST00000322601.1 ENSMUSG00000134131 (from geneSymbol) uc335sqp.1 uc335sqp.1 
ENSMUST00000322602.1 ENSMUSG00000134132 ENSMUST00000322602.1 ENSMUSG00000134132 (from geneSymbol) uc335sqq.1 uc335sqq.1 
ENSMUST00000322603.1 Gm12915 ENSMUST00000322603.1 Gm12915 (from geneSymbol) BC044760 uc335sqr.1 uc335sqr.1 
ENSMUST00000322635.1 ENSMUSG00000134133 ENSMUST00000322635.1 ENSMUSG00000134133 (from geneSymbol) uc335srx.1 uc335srx.1 
ENSMUST00000322662.1 ENSMUSG00000134134 ENSMUST00000322662.1 ENSMUSG00000134134 (from geneSymbol) uc335ssy.1 uc335ssy.1 
ENSMUST00000322668.1 ENSMUSG00000134135 ENSMUST00000322668.1 ENSMUSG00000134135 (from geneSymbol) uc335ste.1 uc335ste.1 
ENSMUST00000322669.1 ENSMUSG00000134136 ENSMUST00000322669.1 ENSMUSG00000134136 (from geneSymbol) uc335stf.1 uc335stf.1 
ENSMUST00000322670.1 Gm13610 ENSMUST00000322670.1 Gm13610 (from geneSymbol) AK076583 uc335stg.1 uc335stg.1 
ENSMUST00000322671.1 ENSMUSG00000134137 ENSMUST00000322671.1 ENSMUSG00000134137 (from geneSymbol) uc335sth.1 uc335sth.1 
ENSMUST00000322672.1 ENSMUSG00000134138 ENSMUST00000322672.1 ENSMUSG00000134138 (from geneSymbol) uc335sti.1 uc335sti.1 
ENSMUST00000322674.1 ENSMUSG00000134139 ENSMUST00000322674.1 ENSMUSG00000134139 (from geneSymbol) uc335stk.1 uc335stk.1 
ENSMUST00000322675.1 ENSMUSG00000134140 ENSMUST00000322675.1 ENSMUSG00000134140 (from geneSymbol) uc335stl.1 uc335stl.1 
ENSMUST00000322683.1 Gm47533 ENSMUST00000322683.1 Gm47533 (from geneSymbol) uc335stt.1 uc335stt.1 
ENSMUST00000322695.1 ENSMUSG00000134141 ENSMUST00000322695.1 ENSMUSG00000134141 (from geneSymbol) uc335suf.1 uc335suf.1 
ENSMUST00000322696.1 ENSMUSG00000134142 ENSMUST00000322696.1 ENSMUSG00000134142 (from geneSymbol) uc335sug.1 uc335sug.1 
ENSMUST00000322698.1 ENSMUSG00000134143 ENSMUST00000322698.1 ENSMUSG00000134143 (from geneSymbol) uc335sui.1 uc335sui.1 
ENSMUST00000322699.1 ENSMUSG00000134144 ENSMUST00000322699.1 ENSMUSG00000134144 (from geneSymbol) uc335suj.1 uc335suj.1 
ENSMUST00000322700.1 ENSMUSG00000134145 ENSMUST00000322700.1 ENSMUSG00000134145 (from geneSymbol) uc335suk.1 uc335suk.1 
ENSMUST00000322701.1 ENSMUSG00000134146 ENSMUST00000322701.1 ENSMUSG00000134146 (from geneSymbol) uc335sul.1 uc335sul.1 
ENSMUST00000322702.1 ENSMUSG00000134147 ENSMUST00000322702.1 ENSMUSG00000134147 (from geneSymbol) uc335sum.1 uc335sum.1 
ENSMUST00000322703.1 ENSMUSG00000134148 ENSMUST00000322703.1 ENSMUSG00000134148 (from geneSymbol) uc335sun.1 uc335sun.1 
ENSMUST00000322710.1 ENSMUSG00000134149 ENSMUST00000322710.1 ENSMUSG00000134149 (from geneSymbol) uc335suu.1 uc335suu.1 
ENSMUST00000322712.1 ENSMUSG00000134151 ENSMUST00000322712.1 ENSMUSG00000134151 (from geneSymbol) uc335suv.1 uc335suv.1 
ENSMUST00000322713.1 ENSMUSG00000134152 ENSMUST00000322713.1 ENSMUSG00000134152 (from geneSymbol) uc335suw.1 uc335suw.1 
ENSMUST00000322714.1 ENSMUSG00000134153 ENSMUST00000322714.1 ENSMUSG00000134153 (from geneSymbol) AK017080 uc335sux.1 uc335sux.1 
ENSMUST00000322722.1 ENSMUSG00000134154 ENSMUST00000322722.1 ENSMUSG00000134154 (from geneSymbol) uc335svf.1 uc335svf.1 
ENSMUST00000322723.1 ENSMUSG00000134155 ENSMUST00000322723.1 ENSMUSG00000134155 (from geneSymbol) uc335svg.1 uc335svg.1 
ENSMUST00000322724.1 1700011L03Rik ENSMUST00000322724.1 1700011L03Rik (from geneSymbol) AK005875 uc335svh.1 uc335svh.1 
ENSMUST00000322728.1 ENSMUSG00000134156 ENSMUST00000322728.1 ENSMUSG00000134156 (from geneSymbol) uc335svl.1 uc335svl.1 
ENSMUST00000322729.1 ENSMUSG00000134157 ENSMUST00000322729.1 ENSMUSG00000134157 (from geneSymbol) uc335svm.1 uc335svm.1 
ENSMUST00000322731.1 ENSMUSG00000134158 ENSMUST00000322731.1 ENSMUSG00000134158 (from geneSymbol) uc335svo.1 uc335svo.1 
ENSMUST00000322735.1 2210417A02Rik ENSMUST00000322735.1 2210417A02Rik (from geneSymbol) KY468077 uc335svs.1 uc335svs.1 
ENSMUST00000322739.1 ENSMUSG00000134159 ENSMUST00000322739.1 ENSMUSG00000134159 (from geneSymbol) uc335svw.1 uc335svw.1 
ENSMUST00000322741.1 ENSMUSG00000134160 ENSMUST00000322741.1 ENSMUSG00000134160 (from geneSymbol) uc335svy.1 uc335svy.1 
ENSMUST00000322745.1 Gm3734 ENSMUST00000322745.1 Gm3734 (from geneSymbol) uc335swc.1 uc335swc.1 
ENSMUST00000322764.1 ENSMUSG00000134161 ENSMUST00000322764.1 ENSMUSG00000134161 (from geneSymbol) uc335swv.1 uc335swv.1 
ENSMUST00000322765.1 ENSMUSG00000134162 ENSMUST00000322765.1 ENSMUSG00000134162 (from geneSymbol) uc335sww.1 uc335sww.1 
ENSMUST00000322769.1 ENSMUSG00000134163 ENSMUST00000322769.1 ENSMUSG00000134163 (from geneSymbol) uc335sxa.1 uc335sxa.1 
ENSMUST00000322770.1 ENSMUSG00000134164 ENSMUST00000322770.1 ENSMUSG00000134164 (from geneSymbol) uc335sxb.1 uc335sxb.1 
ENSMUST00000322773.1 ENSMUSG00000134165 ENSMUST00000322773.1 ENSMUSG00000134165 (from geneSymbol) uc335sxe.1 uc335sxe.1 
ENSMUST00000322775.1 ENSMUSG00000134166 ENSMUST00000322775.1 ENSMUSG00000134166 (from geneSymbol) uc335sxg.1 uc335sxg.1 
ENSMUST00000322776.1 ENSMUSG00000134167 ENSMUST00000322776.1 ENSMUSG00000134167 (from geneSymbol) uc335sxh.1 uc335sxh.1 
ENSMUST00000322777.1 Gm48539 ENSMUST00000322777.1 Gm48539 (from geneSymbol) uc335sxi.1 uc335sxi.1 
ENSMUST00000322780.1 ENSMUSG00000134168 ENSMUST00000322780.1 ENSMUSG00000134168 (from geneSymbol) uc335sxl.1 uc335sxl.1 
ENSMUST00000322781.1 ENSMUSG00000134169 ENSMUST00000322781.1 ENSMUSG00000134169 (from geneSymbol) uc335sxm.1 uc335sxm.1 
ENSMUST00000322785.1 ENSMUSG00000134170 ENSMUST00000322785.1 ENSMUSG00000134170 (from geneSymbol) uc335sxq.1 uc335sxq.1 
ENSMUST00000322787.1 ENSMUSG00000134171 ENSMUST00000322787.1 ENSMUSG00000134171 (from geneSymbol) uc335sxs.1 uc335sxs.1 
ENSMUST00000322788.1 ENSMUSG00000134172 ENSMUST00000322788.1 ENSMUSG00000134172 (from geneSymbol) uc335sxt.1 uc335sxt.1 
ENSMUST00000322789.1 ENSMUSG00000134173 ENSMUST00000322789.1 ENSMUSG00000134173 (from geneSymbol) uc335sxu.1 uc335sxu.1 
ENSMUST00000322791.1 ENSMUSG00000134174 ENSMUST00000322791.1 ENSMUSG00000134174 (from geneSymbol) uc335sxw.1 uc335sxw.1 
ENSMUST00000322792.1 ENSMUSG00000134175 ENSMUST00000322792.1 ENSMUSG00000134175 (from geneSymbol) uc335sxx.1 uc335sxx.1 
ENSMUST00000322796.1 ENSMUSG00000134176 ENSMUST00000322796.1 ENSMUSG00000134176 (from geneSymbol) uc335syb.1 uc335syb.1 
ENSMUST00000322811.1 Gm41043 ENSMUST00000322811.1 Gm41043 (from geneSymbol) uc335syq.1 uc335syq.1 
ENSMUST00000322812.1 ENSMUSG00000134177 ENSMUST00000322812.1 ENSMUSG00000134177 (from geneSymbol) uc335syr.1 uc335syr.1 
ENSMUST00000322819.1 ENSMUSG00000134178 ENSMUST00000322819.1 ENSMUSG00000134178 (from geneSymbol) uc335syy.1 uc335syy.1 
ENSMUST00000322830.1 ENSMUSG00000134179 ENSMUST00000322830.1 ENSMUSG00000134179 (from geneSymbol) uc335szj.1 uc335szj.1 
ENSMUST00000322852.1 Gm38773 ENSMUST00000322852.1 predicted gene, 38773 (from RefSeq NR_168027.1) NR_168027 uc335taf.1 uc335taf.1 
ENSMUST00000322857.1 Gm48823 ENSMUST00000322857.1 Gm48823 (from geneSymbol) uc335tak.1 uc335tak.1 
ENSMUST00000322868.1 ENSMUSG00000134181 ENSMUST00000322868.1 ENSMUSG00000134181 (from geneSymbol) uc335tat.1 uc335tat.1 
ENSMUST00000322881.1 ENSMUSG00000134182 ENSMUST00000322881.1 ENSMUSG00000134182 (from geneSymbol) uc335tbg.1 uc335tbg.1 
ENSMUST00000322894.1 ENSMUSG00000134183 ENSMUST00000322894.1 ENSMUSG00000134183 (from geneSymbol) uc335tbt.1 uc335tbt.1 
ENSMUST00000322896.1 ENSMUSG00000134184 ENSMUST00000322896.1 ENSMUSG00000134184 (from geneSymbol) uc335tbv.1 uc335tbv.1 
ENSMUST00000322897.1 ENSMUSG00000134185 ENSMUST00000322897.1 ENSMUSG00000134185 (from geneSymbol) uc335tbw.1 uc335tbw.1 
ENSMUST00000322898.1 ENSMUSG00000134186 ENSMUST00000322898.1 ENSMUSG00000134186 (from geneSymbol) uc335tbx.1 uc335tbx.1 
ENSMUST00000322899.1 ENSMUSG00000134187 ENSMUST00000322899.1 ENSMUSG00000134187 (from geneSymbol) uc335tby.1 uc335tby.1 
ENSMUST00000322900.1 Gm45600 ENSMUST00000322900.1 Gm45600 (from geneSymbol) uc335tbz.1 uc335tbz.1 
ENSMUST00000322902.1 ENSMUSG00000134188 ENSMUST00000322902.1 ENSMUSG00000134188 (from geneSymbol) uc335tcb.1 uc335tcb.1 
ENSMUST00000322903.1 ENSMUSG00000134189 ENSMUST00000322903.1 ENSMUSG00000134189 (from geneSymbol) uc335tcc.1 uc335tcc.1 
ENSMUST00000322904.1 ENSMUSG00000134190 ENSMUST00000322904.1 ENSMUSG00000134190 (from geneSymbol) uc335tcd.1 uc335tcd.1 
ENSMUST00000322907.1 ENSMUSG00000134191 ENSMUST00000322907.1 ENSMUSG00000134191 (from geneSymbol) uc335tcg.1 uc335tcg.1 
ENSMUST00000322908.1 Gm57272 ENSMUST00000322908.1 Gm57272 (from geneSymbol) uc335tch.1 uc335tch.1 
ENSMUST00000322912.1 Gm29630 ENSMUST00000322912.1 Gm29630 (from geneSymbol) uc335tcl.1 uc335tcl.1 
ENSMUST00000322916.1 Gm31940 ENSMUST00000322916.1 Gm31940 (from geneSymbol) uc335tco.1 uc335tco.1 
ENSMUST00000322928.1 Gm57184 ENSMUST00000322928.1 Gm57184 (from geneSymbol) AK044410 uc335tda.1 uc335tda.1 
ENSMUST00000322992.1 ENSMUSG00000134193 ENSMUST00000322992.1 ENSMUSG00000134193 (from geneSymbol) uc335tfm.1 uc335tfm.1 
ENSMUST00000322996.1 5430400D12Rik ENSMUST00000322996.1 5430400D12Rik (from geneSymbol) AK017243 uc335tfq.1 uc335tfq.1 
ENSMUST00000323008.1 ENSMUSG00000134194 ENSMUST00000323008.1 ENSMUSG00000134194 (from geneSymbol) uc335tgc.1 uc335tgc.1 
ENSMUST00000323022.1 Gm10371 ENSMUST00000323022.1 Gm10371 (from geneSymbol) AK156967 uc335tgq.1 uc335tgq.1 
ENSMUST00000323056.1 ENSMUSG00000134195 ENSMUST00000323056.1 ENSMUSG00000134195 (from geneSymbol) uc335thy.1 uc335thy.1 
ENSMUST00000323057.1 ENSMUSG00000134196 ENSMUST00000323057.1 ENSMUSG00000134196 (from geneSymbol) uc335thz.1 uc335thz.1 
ENSMUST00000323061.1 ENSMUSG00000134197 ENSMUST00000323061.1 ENSMUSG00000134197 (from geneSymbol) uc335tid.1 uc335tid.1 
ENSMUST00000323079.1 Gm19391 ENSMUST00000323079.1 Gm19391 (from geneSymbol) uc335tiv.1 uc335tiv.1 
ENSMUST00000323083.1 ENSMUSG00000134198 ENSMUST00000323083.1 ENSMUSG00000134198 (from geneSymbol) uc335tiz.1 uc335tiz.1 
ENSMUST00000323084.1 ENSMUSG00000134199 ENSMUST00000323084.1 ENSMUSG00000134199 (from geneSymbol) uc335tja.1 uc335tja.1 
ENSMUST00000323095.1 ENSMUSG00000134200 ENSMUST00000323095.1 ENSMUSG00000134200 (from geneSymbol) uc335tjl.1 uc335tjl.1 
ENSMUST00000323096.1 ENSMUSG00000134201 ENSMUST00000323096.1 ENSMUSG00000134201 (from geneSymbol) uc335tjm.1 uc335tjm.1 
ENSMUST00000323099.1 ENSMUSG00000134202 ENSMUST00000323099.1 ENSMUSG00000134202 (from geneSymbol) uc335tjn.1 uc335tjn.1 
ENSMUST00000323101.1 Gm56565 ENSMUST00000323101.1 Gm56565 (from geneSymbol) uc335tjp.1 uc335tjp.1 
ENSMUST00000323108.1 Gm32006 ENSMUST00000323108.1 Gm32006 (from geneSymbol) uc335tjw.1 uc335tjw.1 
ENSMUST00000323162.1 ENSMUSG00000134203 ENSMUST00000323162.1 ENSMUSG00000134203 (from geneSymbol) uc335tly.1 uc335tly.1 
ENSMUST00000323165.1 ENSMUSG00000134204 ENSMUST00000323165.1 ENSMUSG00000134204 (from geneSymbol) uc335tmb.1 uc335tmb.1 
ENSMUST00000323166.1 Gm829 ENSMUST00000323166.1 Gm829 (from geneSymbol) AK147771 uc335tmc.1 uc335tmc.1 
ENSMUST00000323168.1 ENSMUSG00000134205 ENSMUST00000323168.1 ENSMUSG00000134205 (from geneSymbol) uc335tme.1 uc335tme.1 
ENSMUST00000323170.1 ENSMUSG00000134206 ENSMUST00000323170.1 ENSMUSG00000134206 (from geneSymbol) uc335tmg.1 uc335tmg.1 
ENSMUST00000323174.1 ENSMUSG00000134207 ENSMUST00000323174.1 ENSMUSG00000134207 (from geneSymbol) uc335tmk.1 uc335tmk.1 
ENSMUST00000323177.1 ENSMUSG00000134208 ENSMUST00000323177.1 ENSMUSG00000134208 (from geneSymbol) uc335tmn.1 uc335tmn.1 
ENSMUST00000323178.1 ENSMUSG00000134209 ENSMUST00000323178.1 ENSMUSG00000134209 (from geneSymbol) uc335tmo.1 uc335tmo.1 
ENSMUST00000323184.1 ENSMUSG00000134210 ENSMUST00000323184.1 ENSMUSG00000134210 (from geneSymbol) uc335tmu.1 uc335tmu.1 
ENSMUST00000323194.1 ENSMUSG00000134211 ENSMUST00000323194.1 ENSMUSG00000134211 (from geneSymbol) uc335tne.1 uc335tne.1 
ENSMUST00000323197.1 Gm11379 ENSMUST00000323197.1 Gm11379 (from geneSymbol) uc335tnh.1 uc335tnh.1 
ENSMUST00000323210.1 ENSMUSG00000134212 ENSMUST00000323210.1 ENSMUSG00000134212 (from geneSymbol) uc335tnt.1 uc335tnt.1 
ENSMUST00000323211.1 ENSMUSG00000134213 ENSMUST00000323211.1 ENSMUSG00000134213 (from geneSymbol) uc335tnu.1 uc335tnu.1 
ENSMUST00000323212.1 ENSMUSG00000134214 ENSMUST00000323212.1 ENSMUSG00000134214 (from geneSymbol) uc335tnv.1 uc335tnv.1 
ENSMUST00000323297.1 ENSMUSG00000134215 ENSMUST00000323297.1 ENSMUSG00000134215 (from geneSymbol) uc335trc.1 uc335trc.1 
ENSMUST00000323298.1 Gm16892 ENSMUST00000323298.1 Gm16892 (from geneSymbol) AK149401 uc335trd.1 uc335trd.1 
ENSMUST00000323299.1 9130024F11Rik ENSMUST00000323299.1 9130024F11Rik (from geneSymbol) AK046727 uc335tre.1 uc335tre.1 
ENSMUST00000323312.1 ENSMUSG00000134216 ENSMUST00000323312.1 ENSMUSG00000134216 (from geneSymbol) uc335trr.1 uc335trr.1 
ENSMUST00000323336.1 Fzd10os ENSMUST00000323336.1 Fzd10os (from geneSymbol) AK081926 uc335tsp.1 uc335tsp.1 
ENSMUST00000323367.1 ENSMUSG00000134217 ENSMUST00000323367.1 ENSMUSG00000134217 (from geneSymbol) uc335ttu.1 uc335ttu.1 
ENSMUST00000323368.1 ENSMUSG00000134218 ENSMUST00000323368.1 ENSMUSG00000134218 (from geneSymbol) uc335ttv.1 uc335ttv.1 
ENSMUST00000323369.1 ENSMUSG00000134219 ENSMUST00000323369.1 ENSMUSG00000134219 (from geneSymbol) uc335ttw.1 uc335ttw.1 
ENSMUST00000323393.1 ENSMUSG00000134220 ENSMUST00000323393.1 ENSMUSG00000134220 (from geneSymbol) uc335tuu.1 uc335tuu.1 
ENSMUST00000323396.1 ENSMUSG00000134221 ENSMUST00000323396.1 ENSMUSG00000134221 (from geneSymbol) uc335tux.1 uc335tux.1 
ENSMUST00000323398.1 ENSMUSG00000134222 ENSMUST00000323398.1 ENSMUSG00000134222 (from geneSymbol) uc335tuz.1 uc335tuz.1 
ENSMUST00000323399.1 ENSMUSG00000134223 ENSMUST00000323399.1 ENSMUSG00000134223 (from geneSymbol) uc335tva.1 uc335tva.1 
ENSMUST00000323400.1 ENSMUSG00000134224 ENSMUST00000323400.1 ENSMUSG00000134224 (from geneSymbol) uc335tvb.1 uc335tvb.1 
ENSMUST00000323401.1 ENSMUSG00000134225 ENSMUST00000323401.1 ENSMUSG00000134225 (from geneSymbol) uc335tvc.1 uc335tvc.1 
ENSMUST00000323404.1 ENSMUSG00000134226 ENSMUST00000323404.1 ENSMUSG00000134226 (from geneSymbol) uc335tvf.1 uc335tvf.1 
ENSMUST00000323406.1 ENSMUSG00000134227 ENSMUST00000323406.1 ENSMUSG00000134227 (from geneSymbol) uc335tvh.1 uc335tvh.1 
ENSMUST00000323408.1 ENSMUSG00000134228 ENSMUST00000323408.1 ENSMUSG00000134228 (from geneSymbol) uc335tvj.1 uc335tvj.1 
ENSMUST00000323409.1 ENSMUSG00000134229 ENSMUST00000323409.1 ENSMUSG00000134229 (from geneSymbol) uc335tvk.1 uc335tvk.1 
ENSMUST00000323410.1 ENSMUSG00000134230 ENSMUST00000323410.1 ENSMUSG00000134230 (from geneSymbol) uc335tvl.1 uc335tvl.1 
ENSMUST00000323411.1 ENSMUSG00000134231 ENSMUST00000323411.1 ENSMUSG00000134231 (from geneSymbol) uc335tvm.1 uc335tvm.1 
ENSMUST00000323413.1 ENSMUSG00000134232 ENSMUST00000323413.1 ENSMUSG00000134232 (from geneSymbol) uc335tvo.1 uc335tvo.1 
ENSMUST00000323415.1 ENSMUSG00000134233 ENSMUST00000323415.1 ENSMUSG00000134233 (from geneSymbol) uc335tvq.1 uc335tvq.1 
ENSMUST00000323417.1 ENSMUSG00000134235 ENSMUST00000323417.1 ENSMUSG00000134235 (from geneSymbol) uc335tvr.1 uc335tvr.1 
ENSMUST00000323458.1 ENSMUSG00000134236 ENSMUST00000323458.1 ENSMUSG00000134236 (from geneSymbol) uc335txe.1 uc335txe.1 
ENSMUST00000323459.1 ENSMUSG00000134237 ENSMUST00000323459.1 ENSMUSG00000134237 (from geneSymbol) uc335txf.1 uc335txf.1 
ENSMUST00000323464.1 ENSMUSG00000134239 ENSMUST00000323464.1 ENSMUSG00000134239 (from geneSymbol) uc335txh.1 uc335txh.1 
ENSMUST00000323466.1 ENSMUSG00000134240 ENSMUST00000323466.1 ENSMUSG00000134240 (from geneSymbol) uc335txj.1 uc335txj.1 
ENSMUST00000323468.1 ENSMUSG00000134241 ENSMUST00000323468.1 ENSMUSG00000134241 (from geneSymbol) uc335txl.1 uc335txl.1 
ENSMUST00000323475.1 ENSMUSG00000134242 ENSMUST00000323475.1 ENSMUSG00000134242 (from geneSymbol) uc335txs.1 uc335txs.1 
ENSMUST00000323489.1 ENSMUSG00000134243 ENSMUST00000323489.1 ENSMUSG00000134243 (from geneSymbol) uc335tyg.1 uc335tyg.1 
ENSMUST00000323491.1 Gm3134 ENSMUST00000323491.1 Gm3134 (from geneSymbol) uc335tyi.1 uc335tyi.1 
ENSMUST00000323543.1 ENSMUSG00000134244 ENSMUST00000323543.1 ENSMUSG00000134244 (from geneSymbol) uc335uai.1 uc335uai.1 
ENSMUST00000323544.1 ENSMUSG00000134245 ENSMUST00000323544.1 ENSMUSG00000134245 (from geneSymbol) uc335uaj.1 uc335uaj.1 
ENSMUST00000323545.1 ENSMUSG00000134246 ENSMUST00000323545.1 ENSMUSG00000134246 (from geneSymbol) uc335uak.1 uc335uak.1 
ENSMUST00000323546.1 ENSMUSG00000134247 ENSMUST00000323546.1 ENSMUSG00000134247 (from geneSymbol) uc335ual.1 uc335ual.1 
ENSMUST00000323550.1 ENSMUSG00000134248 ENSMUST00000323550.1 ENSMUSG00000134248 (from geneSymbol) uc335uap.1 uc335uap.1 
ENSMUST00000323551.1 ENSMUSG00000134249 ENSMUST00000323551.1 ENSMUSG00000134249 (from geneSymbol) uc335uaq.1 uc335uaq.1 
ENSMUST00000323552.1 ENSMUSG00000134250 ENSMUST00000323552.1 ENSMUSG00000134250 (from geneSymbol) KY467844 uc335uar.1 uc335uar.1 
ENSMUST00000323554.1 ENSMUSG00000134251 ENSMUST00000323554.1 ENSMUSG00000134251 (from geneSymbol) uc335uat.1 uc335uat.1 
ENSMUST00000323557.1 ENSMUSG00000134252 ENSMUST00000323557.1 ENSMUSG00000134252 (from geneSymbol) uc335uaw.1 uc335uaw.1 
ENSMUST00000323559.1 ENSMUSG00000134253 ENSMUST00000323559.1 ENSMUSG00000134253 (from geneSymbol) uc335uay.1 uc335uay.1 
ENSMUST00000323560.1 ENSMUSG00000134254 ENSMUST00000323560.1 ENSMUSG00000134254 (from geneSymbol) uc335uaz.1 uc335uaz.1 
ENSMUST00000323562.1 ENSMUSG00000134255 ENSMUST00000323562.1 ENSMUSG00000134255 (from geneSymbol) uc335ubb.1 uc335ubb.1 
ENSMUST00000323569.1 3010001F23Rik ENSMUST00000323569.1 3010001F23Rik (from geneSymbol) AK013876 uc335ubi.1 uc335ubi.1 
ENSMUST00000323609.1 ENSMUSG00000134256 ENSMUST00000323609.1 ENSMUSG00000134256 (from geneSymbol) uc335ucw.1 uc335ucw.1 
ENSMUST00000323610.1 ENSMUSG00000134257 ENSMUST00000323610.1 ENSMUSG00000134257 (from geneSymbol) uc335ucx.1 uc335ucx.1 
ENSMUST00000323612.1 ENSMUSG00000134258 ENSMUST00000323612.1 ENSMUSG00000134258 (from geneSymbol) LF198996 uc335ucz.1 uc335ucz.1 
ENSMUST00000323613.1 ENSMUSG00000134259 ENSMUST00000323613.1 ENSMUSG00000134259 (from geneSymbol) uc335uda.1 uc335uda.1 
ENSMUST00000323614.1 ENSMUSG00000134260 ENSMUST00000323614.1 ENSMUSG00000134260 (from geneSymbol) uc335udb.1 uc335udb.1 
ENSMUST00000323616.1 Gm53042 ENSMUST00000323616.1 Gm53042 (from geneSymbol) uc335udd.1 uc335udd.1 
ENSMUST00000323629.1 ENSMUSG00000121479 ENSMUST00000323629.1 ENSMUSG00000121479 (from geneSymbol) AK049082 uc335udq.1 uc335udq.1 
ENSMUST00000323665.1 ENSMUSG00000134261 ENSMUST00000323665.1 ENSMUSG00000134261 (from geneSymbol) uc335ufa.1 uc335ufa.1 
ENSMUST00000323666.1 ENSMUSG00000134262 ENSMUST00000323666.1 ENSMUSG00000134262 (from geneSymbol) uc335ufb.1 uc335ufb.1 
ENSMUST00000323676.1 ENSMUSG00000134263 ENSMUST00000323676.1 ENSMUSG00000134263 (from geneSymbol) uc335ufl.1 uc335ufl.1 
ENSMUST00000323679.1 ENSMUSG00000134264 ENSMUST00000323679.1 ENSMUSG00000134264 (from geneSymbol) uc335ufo.1 uc335ufo.1 
ENSMUST00000323681.1 ENSMUSG00000134266 ENSMUST00000323681.1 ENSMUSG00000134266 (from geneSymbol) uc335ufp.1 uc335ufp.1 
ENSMUST00000323684.1 ENSMUSG00000134268 ENSMUST00000323684.1 ENSMUSG00000134268 (from geneSymbol) uc335ufr.1 uc335ufr.1 
ENSMUST00000323686.1 ENSMUSG00000134269 ENSMUST00000323686.1 ENSMUSG00000134269 (from geneSymbol) uc335uft.1 uc335uft.1 
ENSMUST00000323689.1 ENSMUSG00000134270 ENSMUST00000323689.1 ENSMUSG00000134270 (from geneSymbol) uc335ufw.1 uc335ufw.1 
ENSMUST00000323692.1 ENSMUSG00000134271 ENSMUST00000323692.1 ENSMUSG00000134271 (from geneSymbol) uc335ufz.1 uc335ufz.1 
ENSMUST00000323696.1 ENSMUSG00000134272 ENSMUST00000323696.1 ENSMUSG00000134272 (from geneSymbol) uc335ugd.1 uc335ugd.1 
ENSMUST00000323698.1 Gm39478 ENSMUST00000323698.1 predicted gene, 39478 (from RefSeq NR_175337.1) NR_175337 uc335ugf.1 uc335ugf.1 
ENSMUST00000323702.1 ENSMUSG00000134275 ENSMUST00000323702.1 ENSMUSG00000134275 (from geneSymbol) uc335ugh.1 uc335ugh.1 
ENSMUST00000323707.1 ENSMUSG00000134276 ENSMUST00000323707.1 ENSMUSG00000134276 (from geneSymbol) uc335ugm.1 uc335ugm.1 
ENSMUST00000323708.1 ENSMUSG00000121854 ENSMUST00000323708.1 ENSMUSG00000121854 (from geneSymbol) uc335ugn.1 uc335ugn.1 
ENSMUST00000323713.1 ENSMUSG00000134277 ENSMUST00000323713.1 ENSMUSG00000134277 (from geneSymbol) uc335ugs.1 uc335ugs.1 
ENSMUST00000323714.1 Gm11274 ENSMUST00000323714.1 Gm11274 (from geneSymbol) uc335ugt.1 uc335ugt.1 
ENSMUST00000323717.1 ENSMUSG00000134278 ENSMUST00000323717.1 ENSMUSG00000134278 (from geneSymbol) uc335ugw.1 uc335ugw.1 
ENSMUST00000323718.1 ENSMUSG00000134279 ENSMUST00000323718.1 ENSMUSG00000134279 (from geneSymbol) uc335ugx.1 uc335ugx.1 
ENSMUST00000323720.1 ENSMUSG00000134281 ENSMUST00000323720.1 ENSMUSG00000134281 (from geneSymbol) uc335ugy.1 uc335ugy.1 
ENSMUST00000323721.1 ENSMUSG00000134282 ENSMUST00000323721.1 ENSMUSG00000134282 (from geneSymbol) uc335ugz.1 uc335ugz.1 
ENSMUST00000323723.1 ENSMUSG00000134283 ENSMUST00000323723.1 ENSMUSG00000134283 (from geneSymbol) uc335uhb.1 uc335uhb.1 
ENSMUST00000323724.1 ENSMUSG00000134284 ENSMUST00000323724.1 ENSMUSG00000134284 (from geneSymbol) uc335uhc.1 uc335uhc.1 
ENSMUST00000323727.1 ENSMUSG00000134285 ENSMUST00000323727.1 ENSMUSG00000134285 (from geneSymbol) uc335uhf.1 uc335uhf.1 
ENSMUST00000323728.1 ENSMUSG00000134286 ENSMUST00000323728.1 ENSMUSG00000134286 (from geneSymbol) uc335uhg.1 uc335uhg.1 
ENSMUST00000323730.1 ENSMUSG00000134287 ENSMUST00000323730.1 ENSMUSG00000134287 (from geneSymbol) uc335uhi.1 uc335uhi.1 
ENSMUST00000323731.1 ENSMUSG00000134288 ENSMUST00000323731.1 ENSMUSG00000134288 (from geneSymbol) uc335uhj.1 uc335uhj.1 
ENSMUST00000323732.1 ENSMUSG00000134289 ENSMUST00000323732.1 ENSMUSG00000134289 (from geneSymbol) uc335uhk.1 uc335uhk.1 
ENSMUST00000323733.1 ENSMUSG00000134290 ENSMUST00000323733.1 ENSMUSG00000134290 (from geneSymbol) uc335uhl.1 uc335uhl.1 
ENSMUST00000323735.1 Gm54109 ENSMUST00000323735.1 Gm54109 (from geneSymbol) uc335uhn.1 uc335uhn.1 
ENSMUST00000323742.1 Gm56850 ENSMUST00000323742.1 Gm56850 (from geneSymbol) uc335uhu.1 uc335uhu.1 
ENSMUST00000323774.1 ENSMUSG00000134291 ENSMUST00000323774.1 ENSMUSG00000134291 (from geneSymbol) uc335uja.1 uc335uja.1 
ENSMUST00000323775.1 ENSMUSG00000134292 ENSMUST00000323775.1 ENSMUSG00000134292 (from geneSymbol) uc335ujb.1 uc335ujb.1 
ENSMUST00000323781.1 Gm38584 ENSMUST00000323781.1 Gm38584 (from geneSymbol) uc335ujg.1 uc335ujg.1 
ENSMUST00000323785.1 Gm34838 ENSMUST00000323785.1 Gm34838 (from geneSymbol) uc335ujk.1 uc335ujk.1 
ENSMUST00000323789.1 ENSMUSG00000134293 ENSMUST00000323789.1 ENSMUSG00000134293 (from geneSymbol) uc335ujo.1 uc335ujo.1 
ENSMUST00000323790.1 ENSMUSG00000134294 ENSMUST00000323790.1 ENSMUSG00000134294 (from geneSymbol) uc335ujp.1 uc335ujp.1 
ENSMUST00000323794.1 ENSMUSG00000134296 ENSMUST00000323794.1 ENSMUSG00000134296 (from geneSymbol) uc335ujr.1 uc335ujr.1 
ENSMUST00000323795.1 ENSMUSG00000134297 ENSMUST00000323795.1 ENSMUSG00000134297 (from geneSymbol) uc335ujs.1 uc335ujs.1 
ENSMUST00000323799.1 ENSMUSG00000134298 ENSMUST00000323799.1 ENSMUSG00000134298 (from geneSymbol) uc335ujw.1 uc335ujw.1 
ENSMUST00000323800.1 ENSMUSG00000134299 ENSMUST00000323800.1 ENSMUSG00000134299 (from geneSymbol) uc335ujx.1 uc335ujx.1 
ENSMUST00000323801.1 ENSMUSG00000134300 ENSMUST00000323801.1 ENSMUSG00000134300 (from geneSymbol) uc335ujy.1 uc335ujy.1 
ENSMUST00000323803.1 ENSMUSG00000134301 ENSMUST00000323803.1 ENSMUSG00000134301 (from geneSymbol) uc335uka.1 uc335uka.1 
ENSMUST00000323804.1 ENSMUSG00000134302 ENSMUST00000323804.1 ENSMUSG00000134302 (from geneSymbol) uc335ukb.1 uc335ukb.1 
ENSMUST00000323812.1 ENSMUSG00000134303 ENSMUST00000323812.1 ENSMUSG00000134303 (from geneSymbol) AK133277 uc335ukj.1 uc335ukj.1 
ENSMUST00000323818.1 ENSMUSG00000134304 ENSMUST00000323818.1 ENSMUSG00000134304 (from geneSymbol) uc335ukp.1 uc335ukp.1 
ENSMUST00000323836.1 ENSMUSG00000134305 ENSMUST00000323836.1 ENSMUSG00000134305 (from geneSymbol) uc335ulh.1 uc335ulh.1 
ENSMUST00000323840.1 ENSMUSG00000134307 ENSMUST00000323840.1 ENSMUSG00000134307 (from geneSymbol) uc335ulj.1 uc335ulj.1 
ENSMUST00000323844.1 ENSMUSG00000134308 ENSMUST00000323844.1 ENSMUSG00000134308 (from geneSymbol) uc335uln.1 uc335uln.1 
ENSMUST00000323845.1 ENSMUSG00000134309 ENSMUST00000323845.1 ENSMUSG00000134309 (from geneSymbol) uc335ulo.1 uc335ulo.1 
ENSMUST00000323846.1 ENSMUSG00000134310 ENSMUST00000323846.1 ENSMUSG00000134310 (from geneSymbol) uc335ulp.1 uc335ulp.1 
ENSMUST00000323847.1 Gm31107 ENSMUST00000323847.1 Gm31107 (from geneSymbol) uc335ulq.1 uc335ulq.1 
ENSMUST00000323856.1 ENSMUSG00000134311 ENSMUST00000323856.1 ENSMUSG00000134311 (from geneSymbol) uc335ulz.1 uc335ulz.1 
ENSMUST00000323863.1 Gm29010 ENSMUST00000323863.1 Gm29010 (from geneSymbol) uc335umg.1 uc335umg.1 
ENSMUST00000323910.1 ENSMUSG00000134312 ENSMUST00000323910.1 ENSMUSG00000134312 (from geneSymbol) uc335uoa.1 uc335uoa.1 
ENSMUST00000323912.1 ENSMUSG00000134313 ENSMUST00000323912.1 ENSMUSG00000134313 (from geneSymbol) uc335uoc.1 uc335uoc.1 
ENSMUST00000323914.1 ENSMUSG00000134314 ENSMUST00000323914.1 ENSMUSG00000134314 (from geneSymbol) uc335uoe.1 uc335uoe.1 
ENSMUST00000323945.1 ENSMUSG00000134315 ENSMUST00000323945.1 ENSMUSG00000134315 (from geneSymbol) uc335upj.1 uc335upj.1 
ENSMUST00000323946.1 ENSMUSG00000134316 ENSMUST00000323946.1 ENSMUSG00000134316 (from geneSymbol) uc335upk.1 uc335upk.1 
ENSMUST00000323947.1 ENSMUSG00000134317 ENSMUST00000323947.1 ENSMUSG00000134317 (from geneSymbol) uc335upl.1 uc335upl.1 
ENSMUST00000323949.1 ENSMUSG00000134318 ENSMUST00000323949.1 ENSMUSG00000134318 (from geneSymbol) uc335upn.1 uc335upn.1 
ENSMUST00000323950.1 ENSMUSG00000134319 ENSMUST00000323950.1 ENSMUSG00000134319 (from geneSymbol) uc335upo.1 uc335upo.1 
ENSMUST00000323952.1 ENSMUSG00000134320 ENSMUST00000323952.1 ENSMUSG00000134320 (from geneSymbol) FJ654129 uc335upq.1 uc335upq.1 
ENSMUST00000323953.1 ENSMUSG00000134321 ENSMUST00000323953.1 ENSMUSG00000134321 (from geneSymbol) uc335upr.1 uc335upr.1 
ENSMUST00000323955.1 ENSMUSG00000134322 ENSMUST00000323955.1 ENSMUSG00000134322 (from geneSymbol) uc335upt.1 uc335upt.1 
ENSMUST00000323959.1 ENSMUSG00000134323 ENSMUST00000323959.1 ENSMUSG00000134323 (from geneSymbol) uc335upx.1 uc335upx.1 
ENSMUST00000323960.1 ENSMUSG00000134324 ENSMUST00000323960.1 ENSMUSG00000134324 (from geneSymbol) uc335upy.1 uc335upy.1 
ENSMUST00000323961.1 ENSMUSG00000134325 ENSMUST00000323961.1 ENSMUSG00000134325 (from geneSymbol) uc335upz.1 uc335upz.1 
ENSMUST00000323962.1 ENSMUSG00000134326 ENSMUST00000323962.1 ENSMUSG00000134326 (from geneSymbol) AK015461 uc335uqa.1 uc335uqa.1 
ENSMUST00000323963.1 ENSMUSG00000134327 ENSMUST00000323963.1 ENSMUSG00000134327 (from geneSymbol) uc335uqb.1 uc335uqb.1 
ENSMUST00000323964.1 ENSMUSG00000134328 ENSMUST00000323964.1 ENSMUSG00000134328 (from geneSymbol) uc335uqc.1 uc335uqc.1 
ENSMUST00000323966.1 ENSMUSG00000134329 ENSMUST00000323966.1 ENSMUSG00000134329 (from geneSymbol) uc335uqe.1 uc335uqe.1 
ENSMUST00000323968.1 ENSMUSG00000134330 ENSMUST00000323968.1 ENSMUSG00000134330 (from geneSymbol) uc335uqg.1 uc335uqg.1 
ENSMUST00000323969.1 ENSMUSG00000134331 ENSMUST00000323969.1 ENSMUSG00000134331 (from geneSymbol) uc335uqh.1 uc335uqh.1 
ENSMUST00000323970.1 Gm49452 ENSMUST00000323970.1 Gm49452 (from geneSymbol) uc335uqi.1 uc335uqi.1 
ENSMUST00000323971.1 ENSMUSG00000134332 ENSMUST00000323971.1 ENSMUSG00000134332 (from geneSymbol) uc335uqj.1 uc335uqj.1 
ENSMUST00000323972.1 AU019990 ENSMUST00000323972.1 AU019990 (from geneSymbol) AK166556 uc335uqk.1 uc335uqk.1 
ENSMUST00000323979.1 ENSMUSG00000134333 ENSMUST00000323979.1 ENSMUSG00000134333 (from geneSymbol) uc335uqr.1 uc335uqr.1 
ENSMUST00000323982.1 ENSMUSG00000134334 ENSMUST00000323982.1 ENSMUSG00000134334 (from geneSymbol) uc335uqu.1 uc335uqu.1 
ENSMUST00000323983.1 ENSMUSG00000134335 ENSMUST00000323983.1 ENSMUSG00000134335 (from geneSymbol) uc335uqv.1 uc335uqv.1 
ENSMUST00000323986.1 ENSMUSG00000134336 ENSMUST00000323986.1 ENSMUSG00000134336 (from geneSymbol) uc335uqy.1 uc335uqy.1 
ENSMUST00000323987.1 ENSMUSG00000134337 ENSMUST00000323987.1 ENSMUSG00000134337 (from geneSymbol) uc335uqz.1 uc335uqz.1 
ENSMUST00000323988.1 ENSMUSG00000134338 ENSMUST00000323988.1 ENSMUSG00000134338 (from geneSymbol) uc335ura.1 uc335ura.1 
ENSMUST00000323990.1 4930445E18Rik ENSMUST00000323990.1 4930445E18Rik (from geneSymbol) BC100491 uc335urc.1 uc335urc.1 
ENSMUST00000324000.1 ENSMUSG00000134339 ENSMUST00000324000.1 ENSMUSG00000134339 (from geneSymbol) uc335urm.1 uc335urm.1 
ENSMUST00000324003.1 ENSMUSG00000134340 ENSMUST00000324003.1 ENSMUSG00000134340 (from geneSymbol) uc335urp.1 uc335urp.1 
ENSMUST00000324005.1 ENSMUSG00000134341 ENSMUST00000324005.1 ENSMUSG00000134341 (from geneSymbol) uc335urr.1 uc335urr.1 
ENSMUST00000324008.1 ENSMUSG00000134342 ENSMUST00000324008.1 ENSMUSG00000134342 (from geneSymbol) uc335uru.1 uc335uru.1 
ENSMUST00000324009.1 ENSMUSG00000134343 ENSMUST00000324009.1 ENSMUSG00000134343 (from geneSymbol) uc335urv.1 uc335urv.1 
ENSMUST00000324010.1 ENSMUSG00000134344 ENSMUST00000324010.1 ENSMUSG00000134344 (from geneSymbol) uc335urw.1 uc335urw.1 
ENSMUST00000324013.1 ENSMUSG00000134345 ENSMUST00000324013.1 ENSMUSG00000134345 (from geneSymbol) uc335urz.1 uc335urz.1 
ENSMUST00000324019.1 ENSMUSG00000134346 ENSMUST00000324019.1 ENSMUSG00000134346 (from geneSymbol) uc335usf.1 uc335usf.1 
ENSMUST00000324020.1 ENSMUSG00000134347 ENSMUST00000324020.1 ENSMUSG00000134347 (from geneSymbol) uc335usg.1 uc335usg.1 
ENSMUST00000324023.1 ENSMUSG00000134348 ENSMUST00000324023.1 ENSMUSG00000134348 (from geneSymbol) uc335usj.1 uc335usj.1 
ENSMUST00000324024.1 ENSMUSG00000134349 ENSMUST00000324024.1 ENSMUSG00000134349 (from geneSymbol) uc335usk.1 uc335usk.1 
ENSMUST00000324025.1 ENSMUSG00000134350 ENSMUST00000324025.1 ENSMUSG00000134350 (from geneSymbol) uc335usl.1 uc335usl.1 
ENSMUST00000324028.1 Gm33037 ENSMUST00000324028.1 Gm33037 (from geneSymbol) uc335uso.1 uc335uso.1 
ENSMUST00000324055.1 ENSMUSG00000134351 ENSMUST00000324055.1 ENSMUSG00000134351 (from geneSymbol) uc335utp.1 uc335utp.1 
ENSMUST00000324058.1 ENSMUSG00000134352 ENSMUST00000324058.1 ENSMUSG00000134352 (from geneSymbol) AK076861 uc335uts.1 uc335uts.1 
ENSMUST00000324060.1 ENSMUSG00000134353 ENSMUST00000324060.1 ENSMUSG00000134353 (from geneSymbol) uc335utu.1 uc335utu.1 
ENSMUST00000324074.1 Gm14009 ENSMUST00000324074.1 Gm14009 (from geneSymbol) AK144611 uc335uuh.1 uc335uuh.1 
ENSMUST00000324078.1 Gm46376 ENSMUST00000324078.1 Gm46376 (from geneSymbol) uc335uul.1 uc335uul.1 
ENSMUST00000324081.1 ENSMUSG00000134356 ENSMUST00000324081.1 ENSMUSG00000134356 (from geneSymbol) uc335uun.1 uc335uun.1 
ENSMUST00000324097.1 ENSMUSG00000134357 ENSMUST00000324097.1 ENSMUSG00000134357 (from geneSymbol) uc335uvd.1 uc335uvd.1 
ENSMUST00000324100.1 ENSMUSG00000134358 ENSMUST00000324100.1 ENSMUSG00000134358 (from geneSymbol) uc335uvg.1 uc335uvg.1 
ENSMUST00000324106.1 ENSMUSG00000134359 ENSMUST00000324106.1 ENSMUSG00000134359 (from geneSymbol) uc335uvm.1 uc335uvm.1 
ENSMUST00000324107.1 ENSMUSG00000134360 ENSMUST00000324107.1 ENSMUSG00000134360 (from geneSymbol) uc335uvn.1 uc335uvn.1 
ENSMUST00000324112.1 ENSMUSG00000134361 ENSMUST00000324112.1 ENSMUSG00000134361 (from geneSymbol) uc335uvs.1 uc335uvs.1 
ENSMUST00000324114.1 ENSMUSG00000134362 ENSMUST00000324114.1 ENSMUSG00000134362 (from geneSymbol) uc335uvu.1 uc335uvu.1 
ENSMUST00000324115.1 ENSMUSG00000134363 ENSMUST00000324115.1 ENSMUSG00000134363 (from geneSymbol) uc335uvv.1 uc335uvv.1 
ENSMUST00000324116.1 ENSMUSG00000134364 ENSMUST00000324116.1 ENSMUSG00000134364 (from geneSymbol) uc335uvw.1 uc335uvw.1 
ENSMUST00000324119.1 Gm39774 ENSMUST00000324119.1 Gm39774 (from geneSymbol) KJ004570 uc335uvz.1 uc335uvz.1 
ENSMUST00000324125.1 ENSMUSG00000134366 ENSMUST00000324125.1 ENSMUSG00000134366 (from geneSymbol) uc335uwf.1 uc335uwf.1 
ENSMUST00000324127.1 ENSMUSG00000134367 ENSMUST00000324127.1 ENSMUSG00000134367 (from geneSymbol) uc335uwh.1 uc335uwh.1 
ENSMUST00000324128.1 ENSMUSG00000134368 ENSMUST00000324128.1 ENSMUSG00000134368 (from geneSymbol) uc335uwi.1 uc335uwi.1 
ENSMUST00000324130.1 ENSMUSG00000134369 ENSMUST00000324130.1 ENSMUSG00000134369 (from geneSymbol) uc335uwk.1 uc335uwk.1 
ENSMUST00000324131.1 ENSMUSG00000134370 ENSMUST00000324131.1 ENSMUSG00000134370 (from geneSymbol) uc335uwl.1 uc335uwl.1 
ENSMUST00000324132.1 ENSMUSG00000134371 ENSMUST00000324132.1 ENSMUSG00000134371 (from geneSymbol) uc335uwm.1 uc335uwm.1 
ENSMUST00000324133.1 Gm29570 ENSMUST00000324133.1 Gm29570 (from geneSymbol) uc335uwn.1 uc335uwn.1 
ENSMUST00000324137.1 1700072I22Rik ENSMUST00000324137.1 1700072I22Rik (from geneSymbol) AK018891 uc335uwr.1 uc335uwr.1 
ENSMUST00000324149.1 ENSMUSG00000134373 ENSMUST00000324149.1 ENSMUSG00000134373 (from geneSymbol) BC089466 uc335uxd.1 uc335uxd.1 
ENSMUST00000324150.1 ENSMUSG00000134374 ENSMUST00000324150.1 ENSMUSG00000134374 (from geneSymbol) uc335uxe.1 uc335uxe.1 
ENSMUST00000324152.1 ENSMUSG00000134375 ENSMUST00000324152.1 ENSMUSG00000134375 (from geneSymbol) uc335uxg.1 uc335uxg.1 
ENSMUST00000324153.1 ENSMUSG00000134376 ENSMUST00000324153.1 ENSMUSG00000134376 (from geneSymbol) uc335uxh.1 uc335uxh.1 
ENSMUST00000324161.1 ENSMUSG00000134377 ENSMUST00000324161.1 ENSMUSG00000134377 (from geneSymbol) uc335uxn.1 uc335uxn.1 
ENSMUST00000324166.1 ENSMUSG00000134378 ENSMUST00000324166.1 ENSMUSG00000134378 (from geneSymbol) uc335uxs.1 uc335uxs.1 
ENSMUST00000324167.1 ENSMUSG00000134379 ENSMUST00000324167.1 ENSMUSG00000134379 (from geneSymbol) uc335uxt.1 uc335uxt.1 
ENSMUST00000324169.1 ENSMUSG00000134380 ENSMUST00000324169.1 ENSMUSG00000134380 (from geneSymbol) uc335uxv.1 uc335uxv.1 
ENSMUST00000324170.1 ENSMUSG00000134381 ENSMUST00000324170.1 ENSMUSG00000134381 (from geneSymbol) uc335uxw.1 uc335uxw.1 
ENSMUST00000324178.1 ENSMUSG00000134382 ENSMUST00000324178.1 ENSMUSG00000134382 (from geneSymbol) uc335uye.1 uc335uye.1 
ENSMUST00000324204.1 Gm40685 ENSMUST00000324204.1 Gm40685 (from geneSymbol) uc335uze.1 uc335uze.1 
ENSMUST00000324205.1 ENSMUSG00000134383 ENSMUST00000324205.1 ENSMUSG00000134383 (from geneSymbol) uc335uzf.1 uc335uzf.1 
ENSMUST00000324206.1 ENSMUSG00000134384 ENSMUST00000324206.1 ENSMUSG00000134384 (from geneSymbol) uc335uzg.1 uc335uzg.1 
ENSMUST00000324207.1 ENSMUSG00000134385 ENSMUST00000324207.1 ENSMUSG00000134385 (from geneSymbol) uc335uzh.1 uc335uzh.1 
ENSMUST00000324208.1 ENSMUSG00000134386 ENSMUST00000324208.1 ENSMUSG00000134386 (from geneSymbol) uc335uzi.1 uc335uzi.1 
ENSMUST00000324210.1 ENSMUSG00000134387 ENSMUST00000324210.1 ENSMUSG00000134387 (from geneSymbol) uc335uzk.1 uc335uzk.1 
ENSMUST00000324211.1 ENSMUSG00000134388 ENSMUST00000324211.1 ENSMUSG00000134388 (from geneSymbol) uc335uzl.1 uc335uzl.1 
ENSMUST00000324212.1 ENSMUSG00000134389 ENSMUST00000324212.1 ENSMUSG00000134389 (from geneSymbol) uc335uzm.1 uc335uzm.1 
ENSMUST00000324214.1 ENSMUSG00000134390 ENSMUST00000324214.1 ENSMUSG00000134390 (from geneSymbol) uc335uzo.1 uc335uzo.1 
ENSMUST00000324215.1 ENSMUSG00000134391 ENSMUST00000324215.1 ENSMUSG00000134391 (from geneSymbol) uc335uzp.1 uc335uzp.1 
ENSMUST00000324221.1 ENSMUSG00000134393 ENSMUST00000324221.1 ENSMUSG00000134393 (from geneSymbol) uc335uzs.1 uc335uzs.1 
ENSMUST00000324222.1 Gm13010 ENSMUST00000324222.1 Gm13010 (from geneSymbol) uc335uzt.1 uc335uzt.1 
ENSMUST00000324223.1 ENSMUSG00000134394 ENSMUST00000324223.1 ENSMUSG00000134394 (from geneSymbol) uc335uzu.1 uc335uzu.1 
ENSMUST00000324224.1 ENSMUSG00000134395 ENSMUST00000324224.1 ENSMUSG00000134395 (from geneSymbol) uc335uzv.1 uc335uzv.1 
ENSMUST00000324225.1 ENSMUSG00000134396 ENSMUST00000324225.1 ENSMUSG00000134396 (from geneSymbol) uc335uzw.1 uc335uzw.1 
ENSMUST00000324226.1 ENSMUSG00000134397 ENSMUST00000324226.1 ENSMUSG00000134397 (from geneSymbol) uc335uzx.1 uc335uzx.1 
ENSMUST00000324228.1 ENSMUSG00000134398 ENSMUST00000324228.1 ENSMUSG00000134398 (from geneSymbol) uc335uzz.1 uc335uzz.1 
ENSMUST00000324230.1 ENSMUSG00000134399 ENSMUST00000324230.1 ENSMUSG00000134399 (from geneSymbol) uc335vab.1 uc335vab.1 
ENSMUST00000324231.1 ENSMUSG00000134400 ENSMUST00000324231.1 ENSMUSG00000134400 (from geneSymbol) uc335vac.1 uc335vac.1 
ENSMUST00000324232.1 ENSMUSG00000134401 ENSMUST00000324232.1 ENSMUSG00000134401 (from geneSymbol) uc335vad.1 uc335vad.1 
ENSMUST00000324233.1 Gm47376 ENSMUST00000324233.1 Gm47376 (from geneSymbol) uc335vae.1 uc335vae.1 
ENSMUST00000324240.1 Gm12250 ENSMUST00000324240.1 Gm12250 (from geneSymbol) uc335val.1 uc335val.1 
ENSMUST00000324252.1 ENSMUSG00000134403 ENSMUST00000324252.1 ENSMUSG00000134403 (from geneSymbol) uc335vax.1 uc335vax.1 
ENSMUST00000324254.1 ENSMUSG00000134404 ENSMUST00000324254.1 ENSMUSG00000134404 (from geneSymbol) uc335vaz.1 uc335vaz.1 
ENSMUST00000324256.1 Gm31409 ENSMUST00000324256.1 Gm31409 (from geneSymbol) uc335vbb.1 uc335vbb.1 
ENSMUST00000324258.1 ENSMUSG00000134405 ENSMUST00000324258.1 ENSMUSG00000134405 (from geneSymbol) uc335vbd.1 uc335vbd.1 
ENSMUST00000324265.1 ENSMUSG00000134406 ENSMUST00000324265.1 ENSMUSG00000134406 (from geneSymbol) uc335vbk.1 uc335vbk.1 
ENSMUST00000324266.1 ENSMUSG00000134407 ENSMUST00000324266.1 ENSMUSG00000134407 (from geneSymbol) uc335vbl.1 uc335vbl.1 
ENSMUST00000324267.1 ENSMUSG00000134408 ENSMUST00000324267.1 ENSMUSG00000134408 (from geneSymbol) uc335vbm.1 uc335vbm.1 
ENSMUST00000324269.1 ENSMUSG00000134409 ENSMUST00000324269.1 ENSMUSG00000134409 (from geneSymbol) uc335vbo.1 uc335vbo.1 
ENSMUST00000324272.1 1700061N14Rik ENSMUST00000324272.1 1700061N14Rik (from geneSymbol) AK006859 uc335vbr.1 uc335vbr.1 
ENSMUST00000324278.1 ENSMUSG00000134410 ENSMUST00000324278.1 ENSMUSG00000134410 (from geneSymbol) uc335vbx.1 uc335vbx.1 
ENSMUST00000324279.1 4930555G21Rik ENSMUST00000324279.1 4930555G21Rik (from geneSymbol) AK016130 uc335vby.1 uc335vby.1 
ENSMUST00000324282.1 ENSMUSG00000134411 ENSMUST00000324282.1 ENSMUSG00000134411 (from geneSymbol) uc335vcb.1 uc335vcb.1 
ENSMUST00000324283.1 ENSMUSG00000134412 ENSMUST00000324283.1 ENSMUSG00000134412 (from geneSymbol) uc335vcc.1 uc335vcc.1 
ENSMUST00000324285.1 ENSMUSG00000134413 ENSMUST00000324285.1 ENSMUSG00000134413 (from geneSymbol) uc335vce.1 uc335vce.1 
ENSMUST00000324286.1 ENSMUSG00000134414 ENSMUST00000324286.1 ENSMUSG00000134414 (from geneSymbol) uc335vcf.1 uc335vcf.1 
ENSMUST00000324288.1 Gm39323 ENSMUST00000324288.1 Gm39323 (from geneSymbol) uc335vch.1 uc335vch.1 
ENSMUST00000324302.1 ENSMUSG00000134415 ENSMUST00000324302.1 ENSMUSG00000134415 (from geneSymbol) uc335vcv.1 uc335vcv.1 
ENSMUST00000324313.1 ENSMUSG00000134416 ENSMUST00000324313.1 ENSMUSG00000134416 (from geneSymbol) uc335vdg.1 uc335vdg.1 
ENSMUST00000324315.1 ENSMUSG00000134417 ENSMUST00000324315.1 ENSMUSG00000134417 (from geneSymbol) uc335vdi.1 uc335vdi.1 
ENSMUST00000324317.1 ENSMUSG00000134418 ENSMUST00000324317.1 ENSMUSG00000134418 (from geneSymbol) uc335vdk.1 uc335vdk.1 
ENSMUST00000324344.1 ENSMUSG00000134419 ENSMUST00000324344.1 ENSMUSG00000134419 (from geneSymbol) uc335vel.1 uc335vel.1 
ENSMUST00000324345.1 ENSMUSG00000134420 ENSMUST00000324345.1 ENSMUSG00000134420 (from geneSymbol) uc335vem.1 uc335vem.1 
ENSMUST00000324347.1 ENSMUSG00000134421 ENSMUST00000324347.1 ENSMUSG00000134421 (from geneSymbol) uc335veo.1 uc335veo.1 
ENSMUST00000324353.1 Gm57328 ENSMUST00000324353.1 Gm57328 (from geneSymbol) uc335veu.1 uc335veu.1 
ENSMUST00000324363.1 ENSMUSG00000134422 ENSMUST00000324363.1 ENSMUSG00000134422 (from geneSymbol) uc335vfe.1 uc335vfe.1 
ENSMUST00000324368.1 ENSMUSG00000134423 ENSMUST00000324368.1 ENSMUSG00000134423 (from geneSymbol) uc335vfj.1 uc335vfj.1 
ENSMUST00000324369.1 ENSMUSG00000134424 ENSMUST00000324369.1 ENSMUSG00000134424 (from geneSymbol) uc335vfk.1 uc335vfk.1 
ENSMUST00000324370.1 ENSMUSG00000134425 ENSMUST00000324370.1 ENSMUSG00000134425 (from geneSymbol) uc335vfl.1 uc335vfl.1 
ENSMUST00000324373.1 ENSMUSG00000134426 ENSMUST00000324373.1 ENSMUSG00000134426 (from geneSymbol) uc335vfn.1 uc335vfn.1 
ENSMUST00000324380.1 ENSMUSG00000134427 ENSMUST00000324380.1 ENSMUSG00000134427 (from geneSymbol) uc335vfu.1 uc335vfu.1 
ENSMUST00000324383.1 ENSMUSG00000134428 ENSMUST00000324383.1 ENSMUSG00000134428 (from geneSymbol) uc335vfx.1 uc335vfx.1 
ENSMUST00000324384.1 ENSMUSG00000134429 ENSMUST00000324384.1 ENSMUSG00000134429 (from geneSymbol) LF200831 uc335vfy.1 uc335vfy.1 
ENSMUST00000324385.1 ENSMUSG00000134430 ENSMUST00000324385.1 ENSMUSG00000134430 (from geneSymbol) uc335vfz.1 uc335vfz.1 
ENSMUST00000324386.1 ENSMUSG00000134431 ENSMUST00000324386.1 ENSMUSG00000134431 (from geneSymbol) uc335vga.1 uc335vga.1 
ENSMUST00000324388.1 ENSMUSG00000134432 ENSMUST00000324388.1 ENSMUSG00000134432 (from geneSymbol) uc335vgc.1 uc335vgc.1 
ENSMUST00000324390.1 ENSMUSG00000134433 ENSMUST00000324390.1 ENSMUSG00000134433 (from geneSymbol) uc335vge.1 uc335vge.1 
ENSMUST00000324391.1 ENSMUSG00000134434 ENSMUST00000324391.1 ENSMUSG00000134434 (from geneSymbol) uc335vgf.1 uc335vgf.1 
ENSMUST00000324397.1 ENSMUSG00000134435 ENSMUST00000324397.1 ENSMUSG00000134435 (from geneSymbol) uc335vgl.1 uc335vgl.1 
ENSMUST00000324398.1 ENSMUSG00000134436 ENSMUST00000324398.1 ENSMUSG00000134436 (from geneSymbol) uc335vgm.1 uc335vgm.1 
ENSMUST00000324401.1 ENSMUSG00000134437 ENSMUST00000324401.1 ENSMUSG00000134437 (from geneSymbol) DQ705572 uc335vgp.1 uc335vgp.1 
ENSMUST00000324402.1 ENSMUSG00000134438 ENSMUST00000324402.1 ENSMUSG00000134438 (from geneSymbol) uc335vgq.1 uc335vgq.1 
ENSMUST00000324403.1 Gm39929 ENSMUST00000324403.1 Gm39929 (from geneSymbol) uc335vgr.1 uc335vgr.1 
ENSMUST00000324405.1 ENSMUSG00000134439 ENSMUST00000324405.1 ENSMUSG00000134439 (from geneSymbol) uc335vgt.1 uc335vgt.1 
ENSMUST00000324410.1 ENSMUSG00000134440 ENSMUST00000324410.1 ENSMUSG00000134440 (from geneSymbol) uc335vgy.1 uc335vgy.1 
ENSMUST00000324411.1 ENSMUSG00000134441 ENSMUST00000324411.1 ENSMUSG00000134441 (from geneSymbol) uc335vgz.1 uc335vgz.1 
ENSMUST00000324413.1 ENSMUSG00000134442 ENSMUST00000324413.1 ENSMUSG00000134442 (from geneSymbol) uc335vhb.1 uc335vhb.1 
ENSMUST00000324414.1 ENSMUSG00000134443 ENSMUST00000324414.1 ENSMUSG00000134443 (from geneSymbol) uc335vhc.1 uc335vhc.1 
ENSMUST00000324415.1 ENSMUSG00000134444 ENSMUST00000324415.1 ENSMUSG00000134444 (from geneSymbol) uc335vhd.1 uc335vhd.1 
ENSMUST00000324416.1 ENSMUSG00000134445 ENSMUST00000324416.1 ENSMUSG00000134445 (from geneSymbol) uc335vhe.1 uc335vhe.1 
ENSMUST00000324418.1 ENSMUSG00000134446 ENSMUST00000324418.1 ENSMUSG00000134446 (from geneSymbol) uc335vhg.1 uc335vhg.1 
ENSMUST00000324419.1 ENSMUSG00000134447 ENSMUST00000324419.1 ENSMUSG00000134447 (from geneSymbol) uc335vhh.1 uc335vhh.1 
ENSMUST00000324421.1 ENSMUSG00000134448 ENSMUST00000324421.1 ENSMUSG00000134448 (from geneSymbol) uc335vhj.1 uc335vhj.1 
ENSMUST00000324424.1 ENSMUSG00000134449 ENSMUST00000324424.1 ENSMUSG00000134449 (from geneSymbol) uc335vhl.1 uc335vhl.1 
ENSMUST00000324425.1 ENSMUSG00000134450 ENSMUST00000324425.1 ENSMUSG00000134450 (from geneSymbol) uc335vhm.1 uc335vhm.1 
ENSMUST00000324426.1 ENSMUSG00000134451 ENSMUST00000324426.1 ENSMUSG00000134451 (from geneSymbol) LF292762 uc335vhn.1 uc335vhn.1 
ENSMUST00000324429.1 ENSMUSG00000134452 ENSMUST00000324429.1 ENSMUSG00000134452 (from geneSymbol) uc335vhq.1 uc335vhq.1 
ENSMUST00000324431.1 ENSMUSG00000134453 ENSMUST00000324431.1 ENSMUSG00000134453 (from geneSymbol) uc335vhs.1 uc335vhs.1 
ENSMUST00000324432.1 ENSMUSG00000134454 ENSMUST00000324432.1 ENSMUSG00000134454 (from geneSymbol) uc335vht.1 uc335vht.1 
ENSMUST00000324434.1 Gm11958 ENSMUST00000324434.1 Gm11958 (from geneSymbol) uc335vhv.1 uc335vhv.1 
ENSMUST00000324441.1 ENSMUSG00000134455 ENSMUST00000324441.1 ENSMUSG00000134455 (from geneSymbol) uc335vic.1 uc335vic.1 
ENSMUST00000324442.1 Gm57045 ENSMUST00000324442.1 Gm57045 (from geneSymbol) uc335vid.1 uc335vid.1 
ENSMUST00000324445.1 9330188P03Rik ENSMUST00000324445.1 9330188P03Rik (from geneSymbol) AK166274 uc335vig.1 uc335vig.1 
ENSMUST00000324492.1 Platr20 ENSMUST00000324492.1 Platr20 (from geneSymbol) AK017220 uc335vkb.1 uc335vkb.1 
ENSMUST00000324562.1 Gm6551 ENSMUST00000324562.1 Gm6551 (from geneSymbol) uc335vmr.1 uc335vmr.1 
ENSMUST00000324563.1 ENSMUSG00000134457 ENSMUST00000324563.1 ENSMUSG00000134457 (from geneSymbol) uc335vms.1 uc335vms.1 
ENSMUST00000324569.1 ENSMUSG00000134458 ENSMUST00000324569.1 ENSMUSG00000134458 (from geneSymbol) uc335vmy.1 uc335vmy.1 
ENSMUST00000324573.1 Gm2848 ENSMUST00000324573.1 Gm2848 (from geneSymbol) KY467670 uc335vnc.1 uc335vnc.1 
ENSMUST00000324585.1 Gm47713 ENSMUST00000324585.1 Gm47713 (from geneSymbol) uc335vno.1 uc335vno.1 
ENSMUST00000324611.1 ENSMUSG00000134459 ENSMUST00000324611.1 ENSMUSG00000134459 (from geneSymbol) uc335voo.1 uc335voo.1 
ENSMUST00000324615.1 ENSMUSG00000134460 ENSMUST00000324615.1 ENSMUSG00000134460 (from geneSymbol) uc335vos.1 uc335vos.1 
ENSMUST00000324616.1 ENSMUSG00000134461 ENSMUST00000324616.1 ENSMUSG00000134461 (from geneSymbol) uc335vot.1 uc335vot.1 
ENSMUST00000324624.1 Gm52687 ENSMUST00000324624.1 Gm52687 (from geneSymbol) uc335vpb.1 uc335vpb.1 
ENSMUST00000324625.1 ENSMUSG00000134463 ENSMUST00000324625.1 ENSMUSG00000134463 (from geneSymbol) uc335vpc.1 uc335vpc.1 
ENSMUST00000324628.1 4930447K03Rik ENSMUST00000324628.1 4930447K03Rik (from geneSymbol) AK015408 uc335vpf.1 uc335vpf.1 
ENSMUST00000324648.1 ENSMUSG00000134464 ENSMUST00000324648.1 ENSMUSG00000134464 (from geneSymbol) uc335vpz.1 uc335vpz.1 
ENSMUST00000324650.1 ENSMUSG00000134465 ENSMUST00000324650.1 ENSMUSG00000134465 (from geneSymbol) uc335vqb.1 uc335vqb.1 
ENSMUST00000324651.1 ENSMUSG00000134466 ENSMUST00000324651.1 ENSMUSG00000134466 (from geneSymbol) uc335vqc.1 uc335vqc.1 
ENSMUST00000324652.1 ENSMUSG00000134467 ENSMUST00000324652.1 ENSMUSG00000134467 (from geneSymbol) KY467965 uc335vqd.1 uc335vqd.1 
ENSMUST00000324671.1 ENSMUSG00000134468 ENSMUST00000324671.1 ENSMUSG00000134468 (from geneSymbol) uc335vqw.1 uc335vqw.1 
ENSMUST00000324699.1 ENSMUSG00000134469 ENSMUST00000324699.1 ENSMUSG00000134469 (from geneSymbol) uc335vry.1 uc335vry.1 
ENSMUST00000324700.1 ENSMUSG00000134470 ENSMUST00000324700.1 ENSMUSG00000134470 (from geneSymbol) uc335vrz.1 uc335vrz.1 
ENSMUST00000324705.1 ENSMUSG00000134471 ENSMUST00000324705.1 ENSMUSG00000134471 (from geneSymbol) uc335vse.1 uc335vse.1 
ENSMUST00000324720.1 Gm57131 ENSMUST00000324720.1 Gm57131 (from geneSymbol) uc335vss.1 uc335vss.1 
ENSMUST00000324722.1 ENSMUSG00000134472 ENSMUST00000324722.1 ENSMUSG00000134472 (from geneSymbol) uc335vsu.1 uc335vsu.1 
ENSMUST00000324723.1 Gm57148 ENSMUST00000324723.1 Gm57148 (from geneSymbol) uc335vsv.1 uc335vsv.1 
ENSMUST00000324725.1 ENSMUSG00000134473 ENSMUST00000324725.1 ENSMUSG00000134473 (from geneSymbol) uc335vsx.1 uc335vsx.1 
ENSMUST00000324727.1 ENSMUSG00000134474 ENSMUST00000324727.1 ENSMUSG00000134474 (from geneSymbol) uc335vsz.1 uc335vsz.1 
ENSMUST00000324730.1 ENSMUSG00000134475 ENSMUST00000324730.1 ENSMUSG00000134475 (from geneSymbol) uc335vtc.1 uc335vtc.1 
ENSMUST00000324733.1 ENSMUSG00000134476 ENSMUST00000324733.1 ENSMUSG00000134476 (from geneSymbol) uc335vtf.1 uc335vtf.1 
ENSMUST00000324736.1 ENSMUSG00000134478 ENSMUST00000324736.1 ENSMUSG00000134478 (from geneSymbol) uc335vth.1 uc335vth.1 
ENSMUST00000324739.1 ENSMUSG00000134479 ENSMUST00000324739.1 ENSMUSG00000134479 (from geneSymbol) uc335vtk.1 uc335vtk.1 
ENSMUST00000324744.1 ENSMUSG00000134480 ENSMUST00000324744.1 ENSMUSG00000134480 (from geneSymbol) uc335vtp.1 uc335vtp.1 
ENSMUST00000324749.1 ENSMUSG00000134481 ENSMUST00000324749.1 ENSMUSG00000134481 (from geneSymbol) uc335vtu.1 uc335vtu.1 
ENSMUST00000324751.1 ENSMUSG00000134482 ENSMUST00000324751.1 ENSMUSG00000134482 (from geneSymbol) uc335vtw.1 uc335vtw.1 
ENSMUST00000324755.1 Gm47561 ENSMUST00000324755.1 Gm47561 (from geneSymbol) uc335vua.1 uc335vua.1 
ENSMUST00000324767.1 Gm13206 ENSMUST00000324767.1 Gm13206 (from geneSymbol) AK040805 uc335vum.1 uc335vum.1 
ENSMUST00000324805.1 ENSMUSG00000134483 ENSMUST00000324805.1 ENSMUSG00000134483 (from geneSymbol) uc335vvy.1 uc335vvy.1 
ENSMUST00000324807.1 ENSMUSG00000134484 ENSMUST00000324807.1 ENSMUSG00000134484 (from geneSymbol) uc335vwa.1 uc335vwa.1 
ENSMUST00000324808.1 4930448A20Rik ENSMUST00000324808.1 4930448A20Rik (from geneSymbol) AK015411 uc335vwb.1 uc335vwb.1 
ENSMUST00000324810.1 ENSMUSG00000134485 ENSMUST00000324810.1 ENSMUSG00000134485 (from geneSymbol) uc335vwd.1 uc335vwd.1 
ENSMUST00000324813.1 ENSMUSG00000134486 ENSMUST00000324813.1 ENSMUSG00000134486 (from geneSymbol) uc335vwg.1 uc335vwg.1 
ENSMUST00000324814.1 ENSMUSG00000134487 ENSMUST00000324814.1 ENSMUSG00000134487 (from geneSymbol) uc335vwh.1 uc335vwh.1 
ENSMUST00000324819.1 ENSMUSG00000134489 ENSMUST00000324819.1 ENSMUSG00000134489 (from geneSymbol) uc335vwi.1 uc335vwi.1 
ENSMUST00000324821.1 9030622O22Rik ENSMUST00000324821.1 9030622O22Rik (from geneSymbol) KY467906 uc335vwk.1 uc335vwk.1 
ENSMUST00000324959.1 ENSMUSG00000134490 ENSMUST00000324959.1 ENSMUSG00000134490 (from geneSymbol) uc335wbs.1 uc335wbs.1 
ENSMUST00000324961.1 ENSMUSG00000134491 ENSMUST00000324961.1 ENSMUSG00000134491 (from geneSymbol) uc335wbu.1 uc335wbu.1 
ENSMUST00000324962.1 4930422M22Rik ENSMUST00000324962.1 4930422M22Rik (from geneSymbol) AK015183 uc335wbv.1 uc335wbv.1 
ENSMUST00000324982.1 ENSMUSG00000134492 ENSMUST00000324982.1 ENSMUSG00000134492 (from geneSymbol) uc335wcp.1 uc335wcp.1 
ENSMUST00000324983.1 ENSMUSG00000134493 ENSMUST00000324983.1 ENSMUSG00000134493 (from geneSymbol) uc335wcq.1 uc335wcq.1 
ENSMUST00000324984.1 ENSMUSG00000134494 ENSMUST00000324984.1 ENSMUSG00000134494 (from geneSymbol) uc335wcr.1 uc335wcr.1 
ENSMUST00000325001.1 ENSMUSG00000134495 ENSMUST00000325001.1 ENSMUSG00000134495 (from geneSymbol) uc335wdi.1 uc335wdi.1 
ENSMUST00000325009.1 ENSMUSG00000134496 ENSMUST00000325009.1 ENSMUSG00000134496 (from geneSymbol) uc335wdq.1 uc335wdq.1 
ENSMUST00000325013.1 ENSMUSG00000134497 ENSMUST00000325013.1 ENSMUSG00000134497 (from geneSymbol) uc335wdu.1 uc335wdu.1 
ENSMUST00000325015.1 ENSMUSG00000134498 ENSMUST00000325015.1 ENSMUSG00000134498 (from geneSymbol) uc335wdw.1 uc335wdw.1 
ENSMUST00000325033.1 ENSMUSG00000134499 ENSMUST00000325033.1 ENSMUSG00000134499 (from geneSymbol) uc335weo.1 uc335weo.1 
ENSMUST00000325034.1 ENSMUSG00000134500 ENSMUST00000325034.1 ENSMUSG00000134500 (from geneSymbol) uc335wep.1 uc335wep.1 
ENSMUST00000325038.1 ENSMUSG00000134501 ENSMUST00000325038.1 ENSMUSG00000134501 (from geneSymbol) uc335wet.1 uc335wet.1 
ENSMUST00000325040.1 Gm19522 ENSMUST00000325040.1 Gm19522 (from geneSymbol) AK083150 uc335wev.1 uc335wev.1 
ENSMUST00000325042.1 ENSMUSG00000134502 ENSMUST00000325042.1 ENSMUSG00000134502 (from geneSymbol) uc335wex.1 uc335wex.1 
ENSMUST00000325044.1 ENSMUSG00000134503 ENSMUST00000325044.1 ENSMUSG00000134503 (from geneSymbol) uc335wez.1 uc335wez.1 
ENSMUST00000325045.1 ENSMUSG00000134504 ENSMUST00000325045.1 ENSMUSG00000134504 (from geneSymbol) uc335wfa.1 uc335wfa.1 
ENSMUST00000325047.1 ENSMUSG00000134505 ENSMUST00000325047.1 ENSMUSG00000134505 (from geneSymbol) uc335wfc.1 uc335wfc.1 
ENSMUST00000325048.1 ENSMUSG00000134506 ENSMUST00000325048.1 ENSMUSG00000134506 (from geneSymbol) uc335wfd.1 uc335wfd.1 
ENSMUST00000325052.1 ENSMUSG00000134507 ENSMUST00000325052.1 ENSMUSG00000134507 (from geneSymbol) uc335wfh.1 uc335wfh.1 
ENSMUST00000325053.1 ENSMUSG00000134508 ENSMUST00000325053.1 ENSMUSG00000134508 (from geneSymbol) uc335wfi.1 uc335wfi.1 
ENSMUST00000325055.1 ENSMUSG00000134509 ENSMUST00000325055.1 ENSMUSG00000134509 (from geneSymbol) uc335wfk.1 uc335wfk.1 
ENSMUST00000325076.1 ENSMUSG00000134510 ENSMUST00000325076.1 ENSMUSG00000134510 (from geneSymbol) uc335wgf.1 uc335wgf.1 
ENSMUST00000325082.1 ENSMUSG00000134511 ENSMUST00000325082.1 ENSMUSG00000134511 (from geneSymbol) uc335wgl.1 uc335wgl.1 
ENSMUST00000325089.1 Platr22 ENSMUST00000325089.1 Platr22 (from geneSymbol) AK051055 uc335wgs.1 uc335wgs.1 
ENSMUST00000325118.1 ENSMUSG00000134512 ENSMUST00000325118.1 ENSMUSG00000134512 (from geneSymbol) uc335whv.1 uc335whv.1 
ENSMUST00000325119.1 ENSMUSG00000134513 ENSMUST00000325119.1 ENSMUSG00000134513 (from geneSymbol) uc335whw.1 uc335whw.1 
ENSMUST00000325122.1 ENSMUSG00000134514 ENSMUST00000325122.1 ENSMUSG00000134514 (from geneSymbol) uc335whz.1 uc335whz.1 
ENSMUST00000325123.1 ENSMUSG00000134515 ENSMUST00000325123.1 ENSMUSG00000134515 (from geneSymbol) uc335wia.1 uc335wia.1 
ENSMUST00000325124.1 ENSMUSG00000134516 ENSMUST00000325124.1 ENSMUSG00000134516 (from geneSymbol) uc335wib.1 uc335wib.1 
ENSMUST00000325125.1 ENSMUSG00000134517 ENSMUST00000325125.1 ENSMUSG00000134517 (from geneSymbol) uc335wic.1 uc335wic.1 
ENSMUST00000325126.1 ENSMUSG00000134518 ENSMUST00000325126.1 ENSMUSG00000134518 (from geneSymbol) uc335wid.1 uc335wid.1 
ENSMUST00000325128.1 ENSMUSG00000134519 ENSMUST00000325128.1 ENSMUSG00000134519 (from geneSymbol) uc335wif.1 uc335wif.1 
ENSMUST00000325130.1 ENSMUSG00000134520 ENSMUST00000325130.1 ENSMUSG00000134520 (from geneSymbol) uc335wih.1 uc335wih.1 
ENSMUST00000325132.1 ENSMUSG00000134521 ENSMUST00000325132.1 ENSMUSG00000134521 (from geneSymbol) uc335wij.1 uc335wij.1 
ENSMUST00000325133.1 ENSMUSG00000134522 ENSMUST00000325133.1 ENSMUSG00000134522 (from geneSymbol) uc335wik.1 uc335wik.1 
ENSMUST00000325134.1 ENSMUSG00000134523 ENSMUST00000325134.1 ENSMUSG00000134523 (from geneSymbol) uc335wil.1 uc335wil.1 
ENSMUST00000325135.1 ENSMUSG00000134524 ENSMUST00000325135.1 ENSMUSG00000134524 (from geneSymbol) uc335wim.1 uc335wim.1 
ENSMUST00000325136.1 ENSMUSG00000134525 ENSMUST00000325136.1 ENSMUSG00000134525 (from geneSymbol) uc335win.1 uc335win.1 
ENSMUST00000325150.1 ENSMUSG00000134526 ENSMUST00000325150.1 ENSMUSG00000134526 (from geneSymbol) uc335wjb.1 uc335wjb.1 
ENSMUST00000325153.1 ENSMUSG00000134527 ENSMUST00000325153.1 ENSMUSG00000134527 (from geneSymbol) uc335wje.1 uc335wje.1 
ENSMUST00000325154.1 ENSMUSG00000134528 ENSMUST00000325154.1 ENSMUSG00000134528 (from geneSymbol) uc335wjf.1 uc335wjf.1 
ENSMUST00000325160.1 ENSMUSG00000134529 ENSMUST00000325160.1 ENSMUSG00000134529 (from geneSymbol) uc335wjl.1 uc335wjl.1 
ENSMUST00000325164.1 ENSMUSG00000134530 ENSMUST00000325164.1 ENSMUSG00000134530 (from geneSymbol) uc335wjp.1 uc335wjp.1 
ENSMUST00000325165.1 ENSMUSG00000134531 ENSMUST00000325165.1 ENSMUSG00000134531 (from geneSymbol) uc335wjq.1 uc335wjq.1 
ENSMUST00000325167.1 ENSMUSG00000134532 ENSMUST00000325167.1 ENSMUSG00000134532 (from geneSymbol) uc335wjs.1 uc335wjs.1 
ENSMUST00000325168.1 ENSMUSG00000134533 ENSMUST00000325168.1 ENSMUSG00000134533 (from geneSymbol) uc335wjt.1 uc335wjt.1 
ENSMUST00000325170.1 ENSMUSG00000134534 ENSMUST00000325170.1 ENSMUSG00000134534 (from geneSymbol) uc335wjv.1 uc335wjv.1 
ENSMUST00000325172.1 ENSMUSG00000134535 ENSMUST00000325172.1 ENSMUSG00000134535 (from geneSymbol) uc335wjx.1 uc335wjx.1 
ENSMUST00000325174.1 ENSMUSG00000134536 ENSMUST00000325174.1 ENSMUSG00000134536 (from geneSymbol) uc335wjz.1 uc335wjz.1 
ENSMUST00000325176.1 ENSMUSG00000134537 ENSMUST00000325176.1 ENSMUSG00000134537 (from geneSymbol) uc335wkb.1 uc335wkb.1 
ENSMUST00000325180.1 ENSMUSG00000134538 ENSMUST00000325180.1 ENSMUSG00000134538 (from geneSymbol) KY468229 uc335wkf.1 uc335wkf.1 
ENSMUST00000325203.1 1700016G22Rik ENSMUST00000325203.1 1700016G22Rik (from geneSymbol) AK006031 uc335wlc.1 uc335wlc.1 
ENSMUST00000325229.1 ENSMUSG00000134539 ENSMUST00000325229.1 ENSMUSG00000134539 (from geneSymbol) uc335wmc.1 uc335wmc.1 
ENSMUST00000325240.1 4930404H24Rik ENSMUST00000325240.1 4930404H24Rik (from geneSymbol) AK019562 uc335wmn.1 uc335wmn.1 
ENSMUST00000325246.1 ENSMUSG00000134540 ENSMUST00000325246.1 ENSMUSG00000134540 (from geneSymbol) uc335wmt.1 uc335wmt.1 
ENSMUST00000325247.1 ENSMUSG00000134541 ENSMUST00000325247.1 ENSMUSG00000134541 (from geneSymbol) uc335wmu.1 uc335wmu.1 
ENSMUST00000325248.1 ENSMUSG00000134542 ENSMUST00000325248.1 ENSMUSG00000134542 (from geneSymbol) uc335wmv.1 uc335wmv.1 
ENSMUST00000325254.1 ENSMUSG00000134543 ENSMUST00000325254.1 ENSMUSG00000134543 (from geneSymbol) uc335wnb.1 uc335wnb.1 
ENSMUST00000325257.1 Gm36500 ENSMUST00000325257.1 Gm36500 (from geneSymbol) uc335wne.1 uc335wne.1 
ENSMUST00000325265.1 ENSMUSG00000134544 ENSMUST00000325265.1 ENSMUSG00000134544 (from geneSymbol) uc335wnm.1 uc335wnm.1 
ENSMUST00000325270.1 ENSMUSG00000134545 ENSMUST00000325270.1 ENSMUSG00000134545 (from geneSymbol) uc335wnr.1 uc335wnr.1 
ENSMUST00000325273.1 ENSMUSG00000134546 ENSMUST00000325273.1 ENSMUSG00000134546 (from geneSymbol) uc335wnu.1 uc335wnu.1 
ENSMUST00000325276.1 ENSMUSG00000134547 ENSMUST00000325276.1 ENSMUSG00000134547 (from geneSymbol) uc335wnx.1 uc335wnx.1 
ENSMUST00000325277.1 ENSMUSG00000134548 ENSMUST00000325277.1 ENSMUSG00000134548 (from geneSymbol) uc335wny.1 uc335wny.1 
ENSMUST00000325280.1 ENSMUSG00000134549 ENSMUST00000325280.1 ENSMUSG00000134549 (from geneSymbol) uc335wob.1 uc335wob.1 
ENSMUST00000325281.1 ENSMUSG00000134550 ENSMUST00000325281.1 ENSMUSG00000134550 (from geneSymbol) uc335woc.1 uc335woc.1 
ENSMUST00000325290.1 A930006K02Rik ENSMUST00000325290.1 A930006K02Rik (from geneSymbol) AK038602 uc335wol.1 uc335wol.1 
ENSMUST00000325326.1 4933409D19Rik ENSMUST00000325326.1 4933409D19Rik (from geneSymbol) AK016750 uc335wpv.1 uc335wpv.1 
ENSMUST00000325327.1 ENSMUSG00000134551 ENSMUST00000325327.1 ENSMUSG00000134551 (from geneSymbol) uc335wpw.1 uc335wpw.1 
ENSMUST00000325335.1 Ifngas1 ENSMUST00000325335.1 Ifngas1 (from geneSymbol) uc335wqe.1 uc335wqe.1 
ENSMUST00000325356.1 ENSMUSG00000134552 ENSMUST00000325356.1 ENSMUSG00000134552 (from geneSymbol) uc335wqz.1 uc335wqz.1 
ENSMUST00000325359.1 ENSMUSG00000134553 ENSMUST00000325359.1 ENSMUSG00000134553 (from geneSymbol) uc335wrc.1 uc335wrc.1 
ENSMUST00000325362.1 ENSMUSG00000134554 ENSMUST00000325362.1 ENSMUSG00000134554 (from geneSymbol) uc335wrf.1 uc335wrf.1 
ENSMUST00000325385.1 ENSMUSG00000134555 ENSMUST00000325385.1 ENSMUSG00000134555 (from geneSymbol) uc335wsc.1 uc335wsc.1 
ENSMUST00000325386.1 ENSMUSG00000134556 ENSMUST00000325386.1 ENSMUSG00000134556 (from geneSymbol) uc335wsd.1 uc335wsd.1 
ENSMUST00000325387.1 ENSMUSG00000134557 ENSMUST00000325387.1 ENSMUSG00000134557 (from geneSymbol) uc335wse.1 uc335wse.1 
ENSMUST00000325388.1 ENSMUSG00000134558 ENSMUST00000325388.1 ENSMUSG00000134558 (from geneSymbol) uc335wsf.1 uc335wsf.1 
ENSMUST00000325390.1 ENSMUSG00000134559 ENSMUST00000325390.1 ENSMUSG00000134559 (from geneSymbol) uc335wsh.1 uc335wsh.1 
ENSMUST00000325391.1 ENSMUSG00000134560 ENSMUST00000325391.1 ENSMUSG00000134560 (from geneSymbol) AK049715 uc335wsi.1 uc335wsi.1 
ENSMUST00000325392.1 ENSMUSG00000134561 ENSMUST00000325392.1 ENSMUSG00000134561 (from geneSymbol) uc335wsj.1 uc335wsj.1 
ENSMUST00000325393.1 ENSMUSG00000134562 ENSMUST00000325393.1 ENSMUSG00000134562 (from geneSymbol) uc335wsk.1 uc335wsk.1 
ENSMUST00000325400.1 ENSMUSG00000134563 ENSMUST00000325400.1 ENSMUSG00000134563 (from geneSymbol) uc335wsr.1 uc335wsr.1 
ENSMUST00000325401.1 Gm35309 ENSMUST00000325401.1 Gm35309 (from geneSymbol) uc335wss.1 uc335wss.1 
ENSMUST00000325415.1 ENSMUSG00000134564 ENSMUST00000325415.1 ENSMUSG00000134564 (from geneSymbol) uc335wtg.1 uc335wtg.1 
ENSMUST00000325417.1 Gm38560 ENSMUST00000325417.1 Gm38560 (from geneSymbol) KY467549 uc335wti.1 uc335wti.1 
ENSMUST00000325423.1 ENSMUSG00000134565 ENSMUST00000325423.1 ENSMUSG00000134565 (from geneSymbol) uc335wto.1 uc335wto.1 
ENSMUST00000325424.1 ENSMUSG00000134566 ENSMUST00000325424.1 ENSMUSG00000134566 (from geneSymbol) uc335wtp.1 uc335wtp.1 
ENSMUST00000325425.1 ENSMUSG00000134567 ENSMUST00000325425.1 ENSMUSG00000134567 (from geneSymbol) uc335wtq.1 uc335wtq.1 
ENSMUST00000325426.1 ENSMUSG00000134568 ENSMUST00000325426.1 ENSMUSG00000134568 (from geneSymbol) uc335wtr.1 uc335wtr.1 
ENSMUST00000325433.1 Gm20554 ENSMUST00000325433.1 Gm20554 (from geneSymbol) uc335wty.1 uc335wty.1 
ENSMUST00000325441.1 ENSMUSG00000134569 ENSMUST00000325441.1 ENSMUSG00000134569 (from geneSymbol) uc335wug.1 uc335wug.1 
ENSMUST00000325442.1 ENSMUSG00000134570 ENSMUST00000325442.1 ENSMUSG00000134570 (from geneSymbol) uc335wuh.1 uc335wuh.1 
ENSMUST00000325444.1 ENSMUSG00000134571 ENSMUST00000325444.1 ENSMUSG00000134571 (from geneSymbol) uc335wuj.1 uc335wuj.1 
ENSMUST00000325445.1 ENSMUSG00000134572 ENSMUST00000325445.1 ENSMUSG00000134572 (from geneSymbol) uc335wuk.1 uc335wuk.1 
ENSMUST00000325446.1 ENSMUSG00000134573 ENSMUST00000325446.1 ENSMUSG00000134573 (from geneSymbol) uc335wul.1 uc335wul.1 
ENSMUST00000325448.1 ENSMUSG00000134574 ENSMUST00000325448.1 ENSMUSG00000134574 (from geneSymbol) uc335wun.1 uc335wun.1 
ENSMUST00000325454.1 ENSMUSG00000134575 ENSMUST00000325454.1 ENSMUSG00000134575 (from geneSymbol) uc335wut.1 uc335wut.1 
ENSMUST00000325471.1 ENSMUSG00000134577 ENSMUST00000325471.1 ENSMUSG00000134577 (from geneSymbol) uc335wvj.1 uc335wvj.1 
ENSMUST00000325474.1 ENSMUSG00000134578 ENSMUST00000325474.1 ENSMUSG00000134578 (from geneSymbol) uc335wvm.1 uc335wvm.1 
ENSMUST00000325476.1 ENSMUSG00000134579 ENSMUST00000325476.1 ENSMUSG00000134579 (from geneSymbol) uc335wvo.1 uc335wvo.1 
ENSMUST00000325477.1 ENSMUSG00000134580 ENSMUST00000325477.1 ENSMUSG00000134580 (from geneSymbol) uc335wvp.1 uc335wvp.1 
ENSMUST00000325479.1 ENSMUSG00000134581 ENSMUST00000325479.1 ENSMUSG00000134581 (from geneSymbol) uc335wvr.1 uc335wvr.1 
ENSMUST00000325484.1 ENSMUSG00000134582 ENSMUST00000325484.1 ENSMUSG00000134582 (from geneSymbol) uc335wvw.1 uc335wvw.1 
ENSMUST00000325485.1 ENSMUSG00000134583 ENSMUST00000325485.1 ENSMUSG00000134583 (from geneSymbol) uc335wvx.1 uc335wvx.1 
ENSMUST00000325486.1 ENSMUSG00000134584 ENSMUST00000325486.1 ENSMUSG00000134584 (from geneSymbol) AK050617 uc335wvy.1 uc335wvy.1 
ENSMUST00000325487.1 ENSMUSG00000134585 ENSMUST00000325487.1 ENSMUSG00000134585 (from geneSymbol) uc335wvz.1 uc335wvz.1 
ENSMUST00000325488.1 ENSMUSG00000134586 ENSMUST00000325488.1 ENSMUSG00000134586 (from geneSymbol) uc335wwa.1 uc335wwa.1 
ENSMUST00000325497.1 ENSMUSG00000134587 ENSMUST00000325497.1 ENSMUSG00000134587 (from geneSymbol) uc335wwj.1 uc335wwj.1 
ENSMUST00000325499.1 ENSMUSG00000134588 ENSMUST00000325499.1 ENSMUSG00000134588 (from geneSymbol) uc335wwl.1 uc335wwl.1 
ENSMUST00000325501.1 ENSMUSG00000134589 ENSMUST00000325501.1 ENSMUSG00000134589 (from geneSymbol) uc335wwn.1 uc335wwn.1 
ENSMUST00000325504.1 Gm29508 ENSMUST00000325504.1 Gm29508 (from geneSymbol) AK076979 uc335wwq.1 uc335wwq.1 
ENSMUST00000325508.1 ENSMUSG00000134590 ENSMUST00000325508.1 ENSMUSG00000134590 (from geneSymbol) uc335wwu.1 uc335wwu.1 
ENSMUST00000325509.1 4931402G19Rik ENSMUST00000325509.1 RIKEN cDNA 4931402G19 gene (from RefSeq NR_040608.1) NR_040608 uc335wwv.1 uc335wwv.1 
ENSMUST00000325511.1 Magef1 ENSMUST00000325511.1 Magef1 (from geneSymbol) uc335wwx.1 uc335wwx.1 
ENSMUST00000325518.1 ENSMUSG00000134592 ENSMUST00000325518.1 ENSMUSG00000134592 (from geneSymbol) uc335wxe.1 uc335wxe.1 
ENSMUST00000325521.1 ENSMUSG00000134593 ENSMUST00000325521.1 ENSMUSG00000134593 (from geneSymbol) uc335wxh.1 uc335wxh.1 
ENSMUST00000325526.1 ENSMUSG00000134594 ENSMUST00000325526.1 ENSMUSG00000134594 (from geneSymbol) uc335wxm.1 uc335wxm.1 
ENSMUST00000325527.1 ENSMUSG00000134595 ENSMUST00000325527.1 ENSMUSG00000134595 (from geneSymbol) uc335wxn.1 uc335wxn.1 
ENSMUST00000325529.1 ENSMUSG00000134596 ENSMUST00000325529.1 ENSMUSG00000134596 (from geneSymbol) KY467950 uc335wxp.1 uc335wxp.1 
ENSMUST00000325532.1 1700120G11Rik ENSMUST00000325532.1 1700120G11Rik (from geneSymbol) AK007217 uc335wxs.1 uc335wxs.1 
ENSMUST00000325540.1 ENSMUSG00000134597 ENSMUST00000325540.1 ENSMUSG00000134597 (from geneSymbol) uc335wya.1 uc335wya.1 
ENSMUST00000325543.1 ENSMUSG00000134598 ENSMUST00000325543.1 ENSMUSG00000134598 (from geneSymbol) uc335wyd.1 uc335wyd.1 
ENSMUST00000325545.1 Gm38335 ENSMUST00000325545.1 Gm38335 (from geneSymbol) AK078702 uc335wyf.1 uc335wyf.1 
ENSMUST00000325547.1 ENSMUSG00000134599 ENSMUST00000325547.1 ENSMUSG00000134599 (from geneSymbol) uc335wyh.1 uc335wyh.1 
ENSMUST00000325560.1 ENSMUSG00000134600 ENSMUST00000325560.1 ENSMUSG00000134600 (from geneSymbol) AK006430 uc335wyu.1 uc335wyu.1 
ENSMUST00000325561.1 Gm31416 ENSMUST00000325561.1 Gm31416 (from geneSymbol) uc335wyv.1 uc335wyv.1 
ENSMUST00000325588.1 ENSMUSG00000134601 ENSMUST00000325588.1 ENSMUSG00000134601 (from geneSymbol) uc335wzw.1 uc335wzw.1 
ENSMUST00000325589.1 ENSMUSG00000134602 ENSMUST00000325589.1 ENSMUSG00000134602 (from geneSymbol) uc335wzx.1 uc335wzx.1 
ENSMUST00000325590.1 ENSMUSG00000134603 ENSMUST00000325590.1 ENSMUSG00000134603 (from geneSymbol) uc335wzy.1 uc335wzy.1 
ENSMUST00000325591.1 ENSMUSG00000134604 ENSMUST00000325591.1 ENSMUSG00000134604 (from geneSymbol) uc335wzz.1 uc335wzz.1 
ENSMUST00000325592.1 ENSMUSG00000134605 ENSMUST00000325592.1 ENSMUSG00000134605 (from geneSymbol) uc335xaa.1 uc335xaa.1 
ENSMUST00000325596.1 ENSMUSG00000134606 ENSMUST00000325596.1 ENSMUSG00000134606 (from geneSymbol) uc335xae.1 uc335xae.1 
ENSMUST00000325599.1 ENSMUSG00000134607 ENSMUST00000325599.1 ENSMUSG00000134607 (from geneSymbol) uc335xah.1 uc335xah.1 
ENSMUST00000325601.1 ENSMUSG00000134608 ENSMUST00000325601.1 ENSMUSG00000134608 (from geneSymbol) uc335xaj.1 uc335xaj.1 
ENSMUST00000325603.1 ENSMUSG00000134609 ENSMUST00000325603.1 ENSMUSG00000134609 (from geneSymbol) uc335xal.1 uc335xal.1 
ENSMUST00000325611.1 ENSMUSG00000134610 ENSMUST00000325611.1 ENSMUSG00000134610 (from geneSymbol) uc335xat.1 uc335xat.1 
ENSMUST00000325613.1 ENSMUSG00000134611 ENSMUST00000325613.1 ENSMUSG00000134611 (from geneSymbol) uc335xau.1 uc335xau.1 
ENSMUST00000325616.1 Gm34934 ENSMUST00000325616.1 Gm34934 (from geneSymbol) uc335xax.1 uc335xax.1 
ENSMUST00000325631.1 ENSMUSG00000134612 ENSMUST00000325631.1 ENSMUSG00000134612 (from geneSymbol) uc335xbm.1 uc335xbm.1 
ENSMUST00000325636.1 ENSMUSG00000134613 ENSMUST00000325636.1 ENSMUSG00000134613 (from geneSymbol) uc335xbr.1 uc335xbr.1 
ENSMUST00000325646.1 ENSMUSG00000134615 ENSMUST00000325646.1 ENSMUSG00000134615 (from geneSymbol) DQ687749 uc335xca.1 uc335xca.1 
ENSMUST00000325649.1 ENSMUSG00000134616 ENSMUST00000325649.1 ENSMUSG00000134616 (from geneSymbol) uc335xcd.1 uc335xcd.1 
ENSMUST00000325667.1 ENSMUSG00000134617 ENSMUST00000325667.1 ENSMUSG00000134617 (from geneSymbol) uc335xcv.1 uc335xcv.1 
ENSMUST00000325682.1 Gm43131 ENSMUST00000325682.1 Gm43131 (from geneSymbol) uc335xdk.1 uc335xdk.1 
ENSMUST00000325701.1 ENSMUSG00000134618 ENSMUST00000325701.1 ENSMUSG00000134618 (from geneSymbol) uc335xed.1 uc335xed.1 
ENSMUST00000325702.1 Gm46329 ENSMUST00000325702.1 Gm46329 (from geneSymbol) uc335xee.1 uc335xee.1 
ENSMUST00000325732.1 Gm19705 ENSMUST00000325732.1 Gm19705 (from geneSymbol) KY467512 uc335xfi.1 uc335xfi.1 
ENSMUST00000325869.1 ENSMUSG00000134619 ENSMUST00000325869.1 ENSMUSG00000134619 (from geneSymbol) uc335xkp.1 uc335xkp.1 
ENSMUST00000325872.1 Lrp8os3 ENSMUST00000325872.1 Lrp8os3 (from geneSymbol) AK080515 uc335xkr.1 uc335xkr.1 
ENSMUST00000325874.1 ENSMUSG00000134621 ENSMUST00000325874.1 ENSMUSG00000134621 (from geneSymbol) LF199402 uc335xkt.1 uc335xkt.1 
ENSMUST00000325875.1 ENSMUSG00000134622 ENSMUST00000325875.1 ENSMUSG00000134622 (from geneSymbol) uc335xku.1 uc335xku.1 
ENSMUST00000325876.1 ENSMUSG00000134623 ENSMUST00000325876.1 ENSMUSG00000134623 (from geneSymbol) uc335xkv.1 uc335xkv.1 
ENSMUST00000325877.1 ENSMUSG00000134624 ENSMUST00000325877.1 ENSMUSG00000134624 (from geneSymbol) uc335xkw.1 uc335xkw.1 
ENSMUST00000325878.1 ENSMUSG00000134625 ENSMUST00000325878.1 ENSMUSG00000134625 (from geneSymbol) uc335xkx.1 uc335xkx.1 
ENSMUST00000325881.1 ENSMUSG00000134626 ENSMUST00000325881.1 ENSMUSG00000134626 (from geneSymbol) uc335xla.1 uc335xla.1 
ENSMUST00000325883.1 ENSMUSG00000134627 ENSMUST00000325883.1 ENSMUSG00000134627 (from geneSymbol) uc335xlc.1 uc335xlc.1 
ENSMUST00000325885.1 ENSMUSG00000134628 ENSMUST00000325885.1 ENSMUSG00000134628 (from geneSymbol) uc335xle.1 uc335xle.1 
ENSMUST00000325886.1 ENSMUSG00000134629 ENSMUST00000325886.1 ENSMUSG00000134629 (from geneSymbol) uc335xlf.1 uc335xlf.1 
ENSMUST00000325890.1 ENSMUSG00000134630 ENSMUST00000325890.1 ENSMUSG00000134630 (from geneSymbol) uc335xlj.1 uc335xlj.1 
ENSMUST00000325892.1 ENSMUSG00000134631 ENSMUST00000325892.1 ENSMUSG00000134631 (from geneSymbol) uc335xll.1 uc335xll.1 
ENSMUST00000325894.1 ENSMUSG00000134632 ENSMUST00000325894.1 ENSMUSG00000134632 (from geneSymbol) uc335xln.1 uc335xln.1 
ENSMUST00000325895.1 ENSMUSG00000134633 ENSMUST00000325895.1 ENSMUSG00000134633 (from geneSymbol) uc335xlo.1 uc335xlo.1 
ENSMUST00000325897.1 ENSMUSG00000134634 ENSMUST00000325897.1 ENSMUSG00000134634 (from geneSymbol) uc335xlq.1 uc335xlq.1 
ENSMUST00000325911.1 ENSMUSG00000134635 ENSMUST00000325911.1 ENSMUSG00000134635 (from geneSymbol) uc335xme.1 uc335xme.1 
ENSMUST00000325913.1 ENSMUSG00000134636 ENSMUST00000325913.1 ENSMUSG00000134636 (from geneSymbol) uc335xmg.1 uc335xmg.1 
ENSMUST00000325914.1 1700001G11Rik ENSMUST00000325914.1 1700001G11Rik (from geneSymbol) AK005591 uc335xmh.1 uc335xmh.1 
ENSMUST00000325943.1 ENSMUSG00000134637 ENSMUST00000325943.1 ENSMUSG00000134637 (from geneSymbol) uc335xnk.1 uc335xnk.1 
ENSMUST00000325945.1 ENSMUSG00000134638 ENSMUST00000325945.1 ENSMUSG00000134638 (from geneSymbol) AK132829 uc335xnm.1 uc335xnm.1 
ENSMUST00000325949.1 ENSMUSG00000134639 ENSMUST00000325949.1 ENSMUSG00000134639 (from geneSymbol) AK019848 uc335xnq.1 uc335xnq.1 
ENSMUST00000325958.1 Gm46355 ENSMUST00000325958.1 Gm46355 (from geneSymbol) uc335xnz.1 uc335xnz.1 
ENSMUST00000325962.1 ENSMUSG00000134640 ENSMUST00000325962.1 ENSMUSG00000134640 (from geneSymbol) uc335xod.1 uc335xod.1 
ENSMUST00000325963.1 ENSMUSG00000134641 ENSMUST00000325963.1 ENSMUSG00000134641 (from geneSymbol) uc335xoe.1 uc335xoe.1 
ENSMUST00000325964.1 ENSMUSG00000134642 ENSMUST00000325964.1 ENSMUSG00000134642 (from geneSymbol) uc335xof.1 uc335xof.1 
ENSMUST00000325965.1 ENSMUSG00000134643 ENSMUST00000325965.1 ENSMUSG00000134643 (from geneSymbol) uc335xog.1 uc335xog.1 
ENSMUST00000325966.1 ENSMUSG00000134644 ENSMUST00000325966.1 ENSMUSG00000134644 (from geneSymbol) uc335xoh.1 uc335xoh.1 
ENSMUST00000325971.1 1110002J07Rik ENSMUST00000325971.1 RIKEN cDNA 1110002J07 gene, transcript variant 2 (from RefSeq NR_138561.1) NR_138561 uc335xom.1 uc335xom.1 
ENSMUST00000325975.1 Gm37896 ENSMUST00000325975.1 Gm37896 (from geneSymbol) AK044741 uc335xoq.1 uc335xoq.1 
ENSMUST00000325988.1 ENSMUSG00000134645 ENSMUST00000325988.1 ENSMUSG00000134645 (from geneSymbol) uc335xpd.1 uc335xpd.1 
ENSMUST00000325994.1 ENSMUSG00000134646 ENSMUST00000325994.1 ENSMUSG00000134646 (from geneSymbol) uc335xpj.1 uc335xpj.1 
ENSMUST00000325995.1 Gm13855 ENSMUST00000325995.1 Gm13855 (from geneSymbol) uc335xpk.1 uc335xpk.1 
ENSMUST00000326012.1 ENSMUSG00000134647 ENSMUST00000326012.1 ENSMUSG00000134647 (from geneSymbol) uc335xqb.1 uc335xqb.1 
ENSMUST00000326018.1 ENSMUSG00000134648 ENSMUST00000326018.1 ENSMUSG00000134648 (from geneSymbol) uc335xqh.1 uc335xqh.1 
ENSMUST00000326020.1 ENSMUSG00000134649 ENSMUST00000326020.1 ENSMUSG00000134649 (from geneSymbol) uc335xqj.1 uc335xqj.1 
ENSMUST00000326022.1 4930579K19Rik ENSMUST00000326022.1 4930579K19Rik (from geneSymbol) AK077474 uc335xql.1 uc335xql.1 
ENSMUST00000326029.1 ENSMUSG00000134650 ENSMUST00000326029.1 ENSMUSG00000134650 (from geneSymbol) uc335xqs.1 uc335xqs.1 
ENSMUST00000326033.1 ENSMUSG00000134651 ENSMUST00000326033.1 predicted gene 10524 (from RefSeq NR_188743.1) NR_188743 uc335xqw.1 uc335xqw.1 
ENSMUST00000326035.1 ENSMUSG00000134652 ENSMUST00000326035.1 ENSMUSG00000134652 (from geneSymbol) uc335xqy.1 uc335xqy.1 
ENSMUST00000326044.1 ENSMUSG00000134653 ENSMUST00000326044.1 ENSMUSG00000134653 (from geneSymbol) uc335xrh.1 uc335xrh.1 
ENSMUST00000326045.1 ENSMUSG00000134654 ENSMUST00000326045.1 ENSMUSG00000134654 (from geneSymbol) uc335xri.1 uc335xri.1 
ENSMUST00000326048.1 ENSMUSG00000134655 ENSMUST00000326048.1 ENSMUSG00000134655 (from geneSymbol) uc335xrl.1 uc335xrl.1 
ENSMUST00000326051.1 ENSMUSG00000134656 ENSMUST00000326051.1 ENSMUSG00000134656 (from geneSymbol) uc335xro.1 uc335xro.1 
ENSMUST00000326053.1 4930563N14Rik ENSMUST00000326053.1 4930563N14Rik (from geneSymbol) uc335xrq.1 uc335xrq.1 
ENSMUST00000326059.1 ENSMUSG00000134657 ENSMUST00000326059.1 ENSMUSG00000134657 (from geneSymbol) uc335xrw.1 uc335xrw.1 
ENSMUST00000326060.1 ENSMUSG00000134658 ENSMUST00000326060.1 ENSMUSG00000134658 (from geneSymbol) uc335xrx.1 uc335xrx.1 
ENSMUST00000326062.1 Gm56912 ENSMUST00000326062.1 Gm56912 (from geneSymbol) uc335xrz.1 uc335xrz.1 
ENSMUST00000326065.1 ENSMUSG00000134659 ENSMUST00000326065.1 ENSMUSG00000134659 (from geneSymbol) uc335xsc.1 uc335xsc.1 
ENSMUST00000326066.1 ENSMUSG00000134660 ENSMUST00000326066.1 ENSMUSG00000134660 (from geneSymbol) uc335xsd.1 uc335xsd.1 
ENSMUST00000326068.1 Gm47409 ENSMUST00000326068.1 Gm47409 (from geneSymbol) uc335xsf.1 uc335xsf.1 
ENSMUST00000326070.1 Gm56681 ENSMUST00000326070.1 Gm56681 (from geneSymbol) S42506 uc335xsh.1 uc335xsh.1 
ENSMUST00000326072.1 ENSMUSG00000134661 ENSMUST00000326072.1 ENSMUSG00000134661 (from geneSymbol) uc335xsj.1 uc335xsj.1 
ENSMUST00000326073.1 Arhgap27os1 ENSMUST00000326073.1 Arhgap27os1 (from geneSymbol) AK084731 uc335xsk.1 uc335xsk.1 
ENSMUST00000326075.1 ENSMUSG00000134662 ENSMUST00000326075.1 ENSMUSG00000134662 (from geneSymbol) uc335xsm.1 uc335xsm.1 
ENSMUST00000326077.1 ENSMUSG00000134663 ENSMUST00000326077.1 ENSMUSG00000134663 (from geneSymbol) uc335xso.1 uc335xso.1 
ENSMUST00000326079.1 ENSMUSG00000134664 ENSMUST00000326079.1 ENSMUSG00000134664 (from geneSymbol) uc335xsq.1 uc335xsq.1 
ENSMUST00000326082.1 ENSMUSG00000134665 ENSMUST00000326082.1 ENSMUSG00000134665 (from geneSymbol) uc335xst.1 uc335xst.1 
ENSMUST00000326088.1 ENSMUSG00000134666 ENSMUST00000326088.1 ENSMUSG00000134666 (from geneSymbol) uc335xsz.1 uc335xsz.1 
ENSMUST00000326092.1 E130202H07Rik ENSMUST00000326092.1 E130202H07Rik (from geneSymbol) uc335xtd.1 uc335xtd.1 
ENSMUST00000326163.1 ENSMUSG00000134667 ENSMUST00000326163.1 predicted gene 12615 (from RefSeq NR_172464.1) NR_172464 uc335xvv.1 uc335xvv.1 
ENSMUST00000326197.1 Gm56890 ENSMUST00000326197.1 Gm56890 (from geneSymbol) AK144317 uc335xxd.1 uc335xxd.1 
ENSMUST00000326245.1 ENSMUSG00000134668 ENSMUST00000326245.1 ENSMUSG00000134668 (from geneSymbol) uc335xyz.1 uc335xyz.1 
ENSMUST00000326246.1 ENSMUSG00000134669 ENSMUST00000326246.1 ENSMUSG00000134669 (from geneSymbol) uc335xza.1 uc335xza.1 
ENSMUST00000326251.1 ENSMUSG00000134670 ENSMUST00000326251.1 ENSMUSG00000134670 (from geneSymbol) uc335xzf.1 uc335xzf.1 
ENSMUST00000326255.1 ENSMUSG00000134671 ENSMUST00000326255.1 ENSMUSG00000134671 (from geneSymbol) uc335xzj.1 uc335xzj.1 
ENSMUST00000326257.1 ENSMUSG00000134672 ENSMUST00000326257.1 ENSMUSG00000134672 (from geneSymbol) uc335xzl.1 uc335xzl.1 
ENSMUST00000326258.1 5330413P13Rik ENSMUST00000326258.1 5330413P13Rik (from geneSymbol) AK030453 uc335xzm.1 uc335xzm.1 
ENSMUST00000326269.1 ENSMUSG00000134673 ENSMUST00000326269.1 ENSMUSG00000134673 (from geneSymbol) uc335xzx.1 uc335xzx.1 
ENSMUST00000326270.1 ENSMUSG00000134674 ENSMUST00000326270.1 ENSMUSG00000134674 (from geneSymbol) uc335xzy.1 uc335xzy.1 
ENSMUST00000326277.1 ENSMUSG00000134675 ENSMUST00000326277.1 ENSMUSG00000134675 (from geneSymbol) uc335yaf.1 uc335yaf.1 
ENSMUST00000326280.1 ENSMUSG00000134677 ENSMUST00000326280.1 ENSMUSG00000134677 (from geneSymbol) uc335yah.1 uc335yah.1 
ENSMUST00000326282.1 ENSMUSG00000134678 ENSMUST00000326282.1 ENSMUSG00000134678 (from geneSymbol) uc335yaj.1 uc335yaj.1 
ENSMUST00000326283.1 ENSMUSG00000134679 ENSMUST00000326283.1 ENSMUSG00000134679 (from geneSymbol) uc335yak.1 uc335yak.1 
ENSMUST00000326285.1 4930545H06Rik ENSMUST00000326285.1 4930545H06Rik (from geneSymbol) uc335yam.1 uc335yam.1 
ENSMUST00000326294.1 ENSMUSG00000134680 ENSMUST00000326294.1 ENSMUSG00000134680 (from geneSymbol) uc335yav.1 uc335yav.1 
ENSMUST00000326295.1 ENSMUSG00000134681 ENSMUST00000326295.1 ENSMUSG00000134681 (from geneSymbol) uc335yaw.1 uc335yaw.1 
ENSMUST00000326300.1 ENSMUSG00000134682 ENSMUST00000326300.1 ENSMUSG00000134682 (from geneSymbol) uc335ybb.1 uc335ybb.1 
ENSMUST00000326301.1 ENSMUSG00000134683 ENSMUST00000326301.1 ENSMUSG00000134683 (from geneSymbol) uc335ybc.1 uc335ybc.1 
ENSMUST00000326302.1 ENSMUSG00000134684 ENSMUST00000326302.1 ENSMUSG00000134684 (from geneSymbol) uc335ybd.1 uc335ybd.1 
ENSMUST00000326304.1 ENSMUSG00000134685 ENSMUST00000326304.1 ENSMUSG00000134685 (from geneSymbol) uc335ybf.1 uc335ybf.1 
ENSMUST00000326306.1 ENSMUSG00000134686 ENSMUST00000326306.1 ENSMUSG00000134686 (from geneSymbol) uc335ybh.1 uc335ybh.1 
ENSMUST00000326307.1 ENSMUSG00000134687 ENSMUST00000326307.1 ENSMUSG00000134687 (from geneSymbol) uc335ybi.1 uc335ybi.1 
ENSMUST00000326308.1 ENSMUSG00000134688 ENSMUST00000326308.1 ENSMUSG00000134688 (from geneSymbol) uc335ybj.1 uc335ybj.1 
ENSMUST00000326311.1 ENSMUSG00000134689 ENSMUST00000326311.1 ENSMUSG00000134689 (from geneSymbol) uc335ybm.1 uc335ybm.1 
ENSMUST00000326318.1 ENSMUSG00000134690 ENSMUST00000326318.1 ENSMUSG00000134690 (from geneSymbol) uc335ybt.1 uc335ybt.1 
ENSMUST00000326322.1 ENSMUSG00000134692 ENSMUST00000326322.1 ENSMUSG00000134692 (from geneSymbol) uc335ybw.1 uc335ybw.1 
ENSMUST00000326325.1 ENSMUSG00000134693 ENSMUST00000326325.1 ENSMUSG00000134693 (from geneSymbol) uc335ybz.1 uc335ybz.1 
ENSMUST00000326329.1 ENSMUSG00000134694 ENSMUST00000326329.1 ENSMUSG00000134694 (from geneSymbol) uc335ycd.1 uc335ycd.1 
ENSMUST00000326331.1 ENSMUSG00000134695 ENSMUST00000326331.1 ENSMUSG00000134695 (from geneSymbol) uc335ycf.1 uc335ycf.1 
ENSMUST00000326332.1 ENSMUSG00000134696 ENSMUST00000326332.1 ENSMUSG00000134696 (from geneSymbol) uc335ycg.1 uc335ycg.1 
ENSMUST00000326333.1 Lrp8os1 ENSMUST00000326333.1 Lrp8os1 (from geneSymbol) AK019589 uc335ych.1 uc335ych.1 
ENSMUST00000326337.1 ENSMUSG00000134697 ENSMUST00000326337.1 ENSMUSG00000134697 (from geneSymbol) uc335ycl.1 uc335ycl.1 
ENSMUST00000326338.1 ENSMUSG00000134698 ENSMUST00000326338.1 ENSMUSG00000134698 (from geneSymbol) uc335ycm.1 uc335ycm.1 
ENSMUST00000326345.1 ENSMUSG00000134699 ENSMUST00000326345.1 ENSMUSG00000134699 (from geneSymbol) uc335yct.1 uc335yct.1 
ENSMUST00000326348.1 ENSMUSG00000134700 ENSMUST00000326348.1 ENSMUSG00000134700 (from geneSymbol) uc335ycw.1 uc335ycw.1 
ENSMUST00000326349.1 ENSMUSG00000134701 ENSMUST00000326349.1 ENSMUSG00000134701 (from geneSymbol) uc335ycx.1 uc335ycx.1 
ENSMUST00000326366.1 ENSMUSG00000134702 ENSMUST00000326366.1 ENSMUSG00000134702 (from geneSymbol) uc335ydo.1 uc335ydo.1 
ENSMUST00000326367.1 ENSMUSG00000134703 ENSMUST00000326367.1 ENSMUSG00000134703 (from geneSymbol) uc335ydp.1 uc335ydp.1 
ENSMUST00000326368.1 ENSMUSG00000134704 ENSMUST00000326368.1 ENSMUSG00000134704 (from geneSymbol) uc335ydq.1 uc335ydq.1 
ENSMUST00000326370.1 ENSMUSG00000134705 ENSMUST00000326370.1 ENSMUSG00000134705 (from geneSymbol) uc335yds.1 uc335yds.1 
ENSMUST00000326371.1 ENSMUSG00000134706 ENSMUST00000326371.1 ENSMUSG00000134706 (from geneSymbol) uc335ydt.1 uc335ydt.1 
ENSMUST00000326372.1 ENSMUSG00000134707 ENSMUST00000326372.1 ENSMUSG00000134707 (from geneSymbol) uc335ydu.1 uc335ydu.1 
ENSMUST00000326373.1 ENSMUSG00000134708 ENSMUST00000326373.1 ENSMUSG00000134708 (from geneSymbol) uc335ydv.1 uc335ydv.1 
ENSMUST00000326381.1 ENSMUSG00000134709 ENSMUST00000326381.1 ENSMUSG00000134709 (from geneSymbol) AK145269 uc335yed.1 uc335yed.1 
ENSMUST00000326384.1 ENSMUSG00000134710 ENSMUST00000326384.1 ENSMUSG00000134710 (from geneSymbol) uc335yeg.1 uc335yeg.1 
ENSMUST00000326385.1 ENSMUSG00000134711 ENSMUST00000326385.1 ENSMUSG00000134711 (from geneSymbol) uc335yeh.1 uc335yeh.1 
ENSMUST00000326391.1 4930444M15Rik ENSMUST00000326391.1 4930444M15Rik (from geneSymbol) AK015383 uc335yen.1 uc335yen.1 
ENSMUST00000326405.1 ENSMUSG00000134712 ENSMUST00000326405.1 ENSMUSG00000134712 (from geneSymbol) uc335yfb.1 uc335yfb.1 
ENSMUST00000326406.1 ENSMUSG00000134713 ENSMUST00000326406.1 ENSMUSG00000134713 (from geneSymbol) uc335yfc.1 uc335yfc.1 
ENSMUST00000326407.1 Gm12027 ENSMUST00000326407.1 Gm12027 (from geneSymbol) uc335yfd.1 uc335yfd.1 
ENSMUST00000326430.1 ENSMUSG00000134714 ENSMUST00000326430.1 ENSMUSG00000134714 (from geneSymbol) uc335yga.1 uc335yga.1 
ENSMUST00000326431.1 ENSMUSG00000134715 ENSMUST00000326431.1 ENSMUSG00000134715 (from geneSymbol) uc335ygb.1 uc335ygb.1 
ENSMUST00000326432.1 ENSMUSG00000134716 ENSMUST00000326432.1 ENSMUSG00000134716 (from geneSymbol) uc335ygc.1 uc335ygc.1 
ENSMUST00000326482.1 1700012I11Rik ENSMUST00000326482.1 1700012I11Rik (from geneSymbol) AK005914 uc335yia.1 uc335yia.1 
ENSMUST00000326532.1 ENSMUSG00000134717 ENSMUST00000326532.1 ENSMUSG00000134717 (from geneSymbol) uc335yjy.1 uc335yjy.1 
ENSMUST00000326536.1 ENSMUSG00000134718 ENSMUST00000326536.1 ENSMUSG00000134718 (from geneSymbol) uc335ykc.1 uc335ykc.1 
ENSMUST00000326542.1 ENSMUSG00000134719 ENSMUST00000326542.1 ENSMUSG00000134719 (from geneSymbol) uc335yki.1 uc335yki.1 
ENSMUST00000326562.1 ENSMUSG00000134720 ENSMUST00000326562.1 ENSMUSG00000134720 (from geneSymbol) uc335ylc.1 uc335ylc.1 
ENSMUST00000326564.1 ENSMUSG00000134721 ENSMUST00000326564.1 ENSMUSG00000134721 (from geneSymbol) uc335yle.1 uc335yle.1 
ENSMUST00000326565.1 ENSMUSG00000134722 ENSMUST00000326565.1 ENSMUSG00000134722 (from geneSymbol) uc335ylf.1 uc335ylf.1 
ENSMUST00000326566.1 ENSMUSG00000134723 ENSMUST00000326566.1 ENSMUSG00000134723 (from geneSymbol) uc335ylg.1 uc335ylg.1 
ENSMUST00000326568.1 ENSMUSG00000134724 ENSMUST00000326568.1 ENSMUSG00000134724 (from geneSymbol) uc335yli.1 uc335yli.1 
ENSMUST00000326570.1 ENSMUSG00000134725 ENSMUST00000326570.1 ENSMUSG00000134725 (from geneSymbol) uc335ylk.1 uc335ylk.1 
ENSMUST00000326571.1 ENSMUSG00000134726 ENSMUST00000326571.1 ENSMUSG00000134726 (from geneSymbol) uc335yll.1 uc335yll.1 
ENSMUST00000326573.1 Gm42670 ENSMUST00000326573.1 Gm42670 (from geneSymbol) uc335yln.1 uc335yln.1 
ENSMUST00000326581.1 ENSMUSG00000134727 ENSMUST00000326581.1 ENSMUSG00000134727 (from geneSymbol) uc335ylv.1 uc335ylv.1 
ENSMUST00000326582.1 ENSMUSG00000134728 ENSMUST00000326582.1 ENSMUSG00000134728 (from geneSymbol) uc335ylw.1 uc335ylw.1 
ENSMUST00000326584.1 ENSMUSG00000134729 ENSMUST00000326584.1 ENSMUSG00000134729 (from geneSymbol) uc335yly.1 uc335yly.1 
ENSMUST00000326586.1 ENSMUSG00000134730 ENSMUST00000326586.1 ENSMUSG00000134730 (from geneSymbol) uc335yma.1 uc335yma.1 
ENSMUST00000326593.1 ENSMUSG00000134731 ENSMUST00000326593.1 ENSMUSG00000134731 (from geneSymbol) uc335ymh.1 uc335ymh.1 
ENSMUST00000326594.1 ENSMUSG00000134732 ENSMUST00000326594.1 ENSMUSG00000134732 (from geneSymbol) uc335ymi.1 uc335ymi.1 
ENSMUST00000326595.1 ENSMUSG00000134733 ENSMUST00000326595.1 ENSMUSG00000134733 (from geneSymbol) uc335ymj.1 uc335ymj.1 
ENSMUST00000326605.1 ENSMUSG00000134734 ENSMUST00000326605.1 ENSMUSG00000134734 (from geneSymbol) uc335ymt.1 uc335ymt.1 
ENSMUST00000326606.1 ENSMUSG00000134735 ENSMUST00000326606.1 ENSMUSG00000134735 (from geneSymbol) uc335ymu.1 uc335ymu.1 
ENSMUST00000326607.1 ENSMUSG00000134736 ENSMUST00000326607.1 ENSMUSG00000134736 (from geneSymbol) uc335ymv.1 uc335ymv.1 
ENSMUST00000326608.1 ENSMUSG00000134737 ENSMUST00000326608.1 ENSMUSG00000134737 (from geneSymbol) uc335ymw.1 uc335ymw.1 
ENSMUST00000326609.1 ENSMUSG00000134738 ENSMUST00000326609.1 ENSMUSG00000134738 (from geneSymbol) uc335ymx.1 uc335ymx.1 
ENSMUST00000326615.1 ENSMUSG00000134739 ENSMUST00000326615.1 ENSMUSG00000134739 (from geneSymbol) uc335ynd.1 uc335ynd.1 
ENSMUST00000326616.1 ENSMUSG00000134740 ENSMUST00000326616.1 ENSMUSG00000134740 (from geneSymbol) uc335yne.1 uc335yne.1 
ENSMUST00000326618.1 ENSMUSG00000134741 ENSMUST00000326618.1 ENSMUSG00000134741 (from geneSymbol) uc335yng.1 uc335yng.1 
ENSMUST00000326619.1 ENSMUSG00000134742 ENSMUST00000326619.1 ENSMUSG00000134742 (from geneSymbol) uc335ynh.1 uc335ynh.1 
ENSMUST00000326627.1 Gm11884 ENSMUST00000326627.1 Gm11884 (from geneSymbol) uc335ynp.1 uc335ynp.1 
ENSMUST00000326652.1 ENSMUSG00000134743 ENSMUST00000326652.1 ENSMUSG00000134743 (from geneSymbol) uc335yoo.1 uc335yoo.1 
ENSMUST00000326654.1 Gm48556 ENSMUST00000326654.1 Gm48556 (from geneSymbol) uc335yoq.1 uc335yoq.1 
ENSMUST00000326658.1 ENSMUSG00000134744 ENSMUST00000326658.1 ENSMUSG00000134744 (from geneSymbol) uc335you.1 uc335you.1 
ENSMUST00000326661.1 ENSMUSG00000134745 ENSMUST00000326661.1 ENSMUSG00000134745 (from geneSymbol) uc335yox.1 uc335yox.1 
ENSMUST00000326663.1 ENSMUSG00000134746 ENSMUST00000326663.1 ENSMUSG00000134746 (from geneSymbol) AK139527 uc335yoz.1 uc335yoz.1 
ENSMUST00000326666.1 ENSMUSG00000134747 ENSMUST00000326666.1 ENSMUSG00000134747 (from geneSymbol) uc335ypc.1 uc335ypc.1 
ENSMUST00000326684.1 ENSMUSG00000134748 ENSMUST00000326684.1 ENSMUSG00000134748 (from geneSymbol) uc335ypu.1 uc335ypu.1 
ENSMUST00000326685.1 ENSMUSG00000134749 ENSMUST00000326685.1 ENSMUSG00000134749 (from geneSymbol) uc335ypv.1 uc335ypv.1 
ENSMUST00000326686.1 Gm52513 ENSMUST00000326686.1 Gm52513 (from geneSymbol) uc335ypw.1 uc335ypw.1 
ENSMUST00000326702.1 ENSMUSG00000134751 ENSMUST00000326702.1 ENSMUSG00000134751 (from geneSymbol) uc335yqm.1 uc335yqm.1 
ENSMUST00000326712.1 ENSMUSG00000134752 ENSMUST00000326712.1 ENSMUSG00000134752 (from geneSymbol) uc335yqw.1 uc335yqw.1 
ENSMUST00000326717.1 ENSMUSG00000134753 ENSMUST00000326717.1 ENSMUSG00000134753 (from geneSymbol) uc335yrb.1 uc335yrb.1 
ENSMUST00000326718.1 ENSMUSG00000134754 ENSMUST00000326718.1 ENSMUSG00000134754 (from geneSymbol) uc335yrc.1 uc335yrc.1 
ENSMUST00000326719.1 ENSMUSG00000134755 ENSMUST00000326719.1 ENSMUSG00000134755 (from geneSymbol) uc335yrd.1 uc335yrd.1 
ENSMUST00000326722.1 Gm39792 ENSMUST00000326722.1 Gm39792 (from geneSymbol) uc335yrg.1 uc335yrg.1 
ENSMUST00000326723.1 ENSMUSG00000134756 ENSMUST00000326723.1 ENSMUSG00000134756 (from geneSymbol) uc335yrh.1 uc335yrh.1 
ENSMUST00000326726.1 ENSMUSG00000134757 ENSMUST00000326726.1 ENSMUSG00000134757 (from geneSymbol) uc335yrk.1 uc335yrk.1 
ENSMUST00000326762.1 ENSMUSG00000134758 ENSMUST00000326762.1 ENSMUSG00000134758 (from geneSymbol) uc335ysu.1 uc335ysu.1 
ENSMUST00000326772.1 ENSMUSG00000134759 ENSMUST00000326772.1 ENSMUSG00000134759 (from geneSymbol) uc335yte.1 uc335yte.1 
ENSMUST00000326776.1 ENSMUSG00000134760 ENSMUST00000326776.1 ENSMUSG00000134760 (from geneSymbol) LF196150 uc335yti.1 uc335yti.1 
ENSMUST00000326777.1 ENSMUSG00000134761 ENSMUST00000326777.1 ENSMUSG00000134761 (from geneSymbol) uc335ytj.1 uc335ytj.1 
ENSMUST00000326779.1 Gm49678 ENSMUST00000326779.1 Gm49678 (from geneSymbol) uc335ytl.1 uc335ytl.1 
ENSMUST00000326794.1 ENSMUSG00000134762 ENSMUST00000326794.1 ENSMUSG00000134762 (from geneSymbol) uc335yua.1 uc335yua.1 
ENSMUST00000326797.1 ENSMUSG00000134763 ENSMUST00000326797.1 ENSMUSG00000134763 (from geneSymbol) uc335yud.1 uc335yud.1 
ENSMUST00000326798.1 ENSMUSG00000134764 ENSMUST00000326798.1 ENSMUSG00000134764 (from geneSymbol) uc335yue.1 uc335yue.1 
ENSMUST00000326799.1 ENSMUSG00000134765 ENSMUST00000326799.1 ENSMUSG00000134765 (from geneSymbol) uc335yuf.1 uc335yuf.1 
ENSMUST00000326801.1 Gm6135 ENSMUST00000326801.1 Gm6135 (from geneSymbol) uc335yuh.1 uc335yuh.1 
ENSMUST00000326822.1 ENSMUSG00000134766 ENSMUST00000326822.1 ENSMUSG00000134766 (from geneSymbol) uc335yvc.1 uc335yvc.1 
ENSMUST00000326824.1 ENSMUSG00000134767 ENSMUST00000326824.1 ENSMUSG00000134767 (from geneSymbol) uc335yve.1 uc335yve.1 
ENSMUST00000326825.1 ENSMUSG00000134768 ENSMUST00000326825.1 ENSMUSG00000134768 (from geneSymbol) uc335yvf.1 uc335yvf.1 
ENSMUST00000326833.1 ENSMUSG00000134769 ENSMUST00000326833.1 ENSMUSG00000134769 (from geneSymbol) uc335yvn.1 uc335yvn.1 
ENSMUST00000326842.1 ENSMUSG00000134770 ENSMUST00000326842.1 ENSMUSG00000134770 (from geneSymbol) uc335yvw.1 uc335yvw.1 
ENSMUST00000326854.1 ENSMUSG00000134771 ENSMUST00000326854.1 ENSMUSG00000134771 (from geneSymbol) uc335ywi.1 uc335ywi.1 
ENSMUST00000326861.1 ENSMUSG00000134772 ENSMUST00000326861.1 ENSMUSG00000134772 (from geneSymbol) LF198765 uc335ywp.1 uc335ywp.1 
ENSMUST00000326873.1 ENSMUSG00000134773 ENSMUST00000326873.1 ENSMUSG00000134773 (from geneSymbol) uc335yxb.1 uc335yxb.1 
ENSMUST00000326874.1 ENSMUSG00000134774 ENSMUST00000326874.1 ENSMUSG00000134774 (from geneSymbol) uc335yxc.1 uc335yxc.1 
ENSMUST00000326877.1 1700034K08Rik ENSMUST00000326877.1 1700034K08Rik (from geneSymbol) AK018841 uc335yxf.1 uc335yxf.1 
ENSMUST00000326884.1 ENSMUSG00000134775 ENSMUST00000326884.1 ENSMUSG00000134775 (from geneSymbol) uc335yxm.1 uc335yxm.1 
ENSMUST00000326886.1 ENSMUSG00000134776 ENSMUST00000326886.1 ENSMUSG00000134776 (from geneSymbol) uc335yxo.1 uc335yxo.1 
ENSMUST00000326892.1 ENSMUSG00000134777 ENSMUST00000326892.1 ENSMUSG00000134777 (from geneSymbol) uc335yxu.1 uc335yxu.1 
ENSMUST00000326893.1 ENSMUSG00000134778 ENSMUST00000326893.1 ENSMUSG00000134778 (from geneSymbol) uc335yxv.1 uc335yxv.1 
ENSMUST00000326917.1 ENSMUSG00000134779 ENSMUST00000326917.1 ENSMUSG00000134779 (from geneSymbol) uc335yyt.1 uc335yyt.1 
ENSMUST00000326918.1 ENSMUSG00000134780 ENSMUST00000326918.1 ENSMUSG00000134780 (from geneSymbol) uc335yyu.1 uc335yyu.1 
ENSMUST00000326924.1 ENSMUSG00000134781 ENSMUST00000326924.1 ENSMUSG00000134781 (from geneSymbol) uc335yza.1 uc335yza.1 
ENSMUST00000326948.1 ENSMUSG00000134782 ENSMUST00000326948.1 ENSMUSG00000134782 (from geneSymbol) uc335yzy.1 uc335yzy.1 
ENSMUST00000326962.1 ENSMUSG00000134783 ENSMUST00000326962.1 ENSMUSG00000134783 (from geneSymbol) uc335zam.1 uc335zam.1 
ENSMUST00000326965.1 ENSMUSG00000134784 ENSMUST00000326965.1 ENSMUSG00000134784 (from geneSymbol) uc335zap.1 uc335zap.1 
ENSMUST00000326967.1 ENSMUSG00000134785 ENSMUST00000326967.1 ENSMUSG00000134785 (from geneSymbol) M29010 uc335zar.1 uc335zar.1 
ENSMUST00000326976.1 ENSMUSG00000134786 ENSMUST00000326976.1 ENSMUSG00000134786 (from geneSymbol) uc335zba.1 uc335zba.1 
ENSMUST00000326978.1 ENSMUSG00000134787 ENSMUST00000326978.1 ENSMUSG00000134787 (from geneSymbol) uc335zbc.1 uc335zbc.1 
ENSMUST00000326979.1 Gm40548 ENSMUST00000326979.1 Gm40548 (from geneSymbol) uc335zbd.1 uc335zbd.1 
ENSMUST00000326980.1 Gm48845 ENSMUST00000326980.1 Gm48845 (from geneSymbol) uc335zbe.1 uc335zbe.1 
ENSMUST00000326981.1 ENSMUSG00000134788 ENSMUST00000326981.1 ENSMUSG00000134788 (from geneSymbol) uc335zbf.1 uc335zbf.1 
ENSMUST00000326982.1 ENSMUSG00000134789 ENSMUST00000326982.1 ENSMUSG00000134789 (from geneSymbol) uc335zbg.1 uc335zbg.1 
ENSMUST00000326983.1 ENSMUSG00000134790 ENSMUST00000326983.1 ENSMUSG00000134790 (from geneSymbol) uc335zbh.1 uc335zbh.1 
ENSMUST00000326984.1 ENSMUSG00000134791 ENSMUST00000326984.1 ENSMUSG00000134791 (from geneSymbol) uc335zbi.1 uc335zbi.1 
ENSMUST00000326985.1 ENSMUSG00000134792 ENSMUST00000326985.1 ENSMUSG00000134792 (from geneSymbol) uc335zbj.1 uc335zbj.1 
ENSMUST00000326986.1 Gm49560 ENSMUST00000326986.1 Gm49560 (from geneSymbol) uc335zbk.1 uc335zbk.1 
ENSMUST00000326988.1 ENSMUSG00000134793 ENSMUST00000326988.1 ENSMUSG00000134793 (from geneSymbol) uc335zbm.1 uc335zbm.1 
ENSMUST00000326989.1 ENSMUSG00000134794 ENSMUST00000326989.1 ENSMUSG00000134794 (from geneSymbol) uc335zbn.1 uc335zbn.1 
ENSMUST00000326990.1 5930438M14Rik ENSMUST00000326990.1 5930438M14Rik (from geneSymbol) AK031263 uc335zbo.1 uc335zbo.1 
ENSMUST00000326994.1 ENSMUSG00000134795 ENSMUST00000326994.1 ENSMUSG00000134795 (from geneSymbol) uc335zbs.1 uc335zbs.1 
ENSMUST00000326995.1 ENSMUSG00000134796 ENSMUST00000326995.1 ENSMUSG00000134796 (from geneSymbol) uc335zbt.1 uc335zbt.1 
ENSMUST00000326998.1 ENSMUSG00000134797 ENSMUST00000326998.1 ENSMUSG00000134797 (from geneSymbol) uc335zbw.1 uc335zbw.1 
ENSMUST00000327001.1 ENSMUSG00000134798 ENSMUST00000327001.1 ENSMUSG00000134798 (from geneSymbol) uc335zbz.1 uc335zbz.1 
ENSMUST00000327002.1 ENSMUSG00000134799 ENSMUST00000327002.1 ENSMUSG00000134799 (from geneSymbol) uc335zca.1 uc335zca.1 
ENSMUST00000327008.1 ENSMUSG00000134800 ENSMUST00000327008.1 ENSMUSG00000134800 (from geneSymbol) uc335zcg.1 uc335zcg.1 
ENSMUST00000327026.1 Gm27226 ENSMUST00000327026.1 Gm27226 (from geneSymbol) AK076688 uc335zcx.1 uc335zcx.1 
ENSMUST00000327028.1 ENSMUSG00000134801 ENSMUST00000327028.1 ENSMUSG00000134801 (from geneSymbol) uc335zcz.1 uc335zcz.1 
ENSMUST00000327029.1 ENSMUSG00000134802 ENSMUST00000327029.1 ENSMUSG00000134802 (from geneSymbol) uc335zda.1 uc335zda.1 
ENSMUST00000327031.1 ENSMUSG00000134803 ENSMUST00000327031.1 ENSMUSG00000134803 (from geneSymbol) uc335zdc.1 uc335zdc.1 
ENSMUST00000327033.1 ENSMUSG00000134804 ENSMUST00000327033.1 ENSMUSG00000134804 (from geneSymbol) uc335zde.1 uc335zde.1 
ENSMUST00000327034.1 ENSMUSG00000134805 ENSMUST00000327034.1 ENSMUSG00000134805 (from geneSymbol) uc335zdf.1 uc335zdf.1 
ENSMUST00000327035.1 ENSMUSG00000134806 ENSMUST00000327035.1 ENSMUSG00000134806 (from geneSymbol) uc335zdg.1 uc335zdg.1 
ENSMUST00000327037.1 ENSMUSG00000134807 ENSMUST00000327037.1 ENSMUSG00000134807 (from geneSymbol) uc335zdi.1 uc335zdi.1 
ENSMUST00000327044.1 ENSMUSG00000134808 ENSMUST00000327044.1 ENSMUSG00000134808 (from geneSymbol) uc335zdp.1 uc335zdp.1 
ENSMUST00000327046.1 ENSMUSG00000134809 ENSMUST00000327046.1 ENSMUSG00000134809 (from geneSymbol) uc335zdr.1 uc335zdr.1 
ENSMUST00000327055.1 ENSMUSG00000134810 ENSMUST00000327055.1 ENSMUSG00000134810 (from geneSymbol) uc335zea.1 uc335zea.1 
ENSMUST00000327062.1 ENSMUSG00000134811 ENSMUST00000327062.1 ENSMUSG00000134811 (from geneSymbol) uc335zeh.1 uc335zeh.1 
ENSMUST00000327068.1 ENSMUSG00000134812 ENSMUST00000327068.1 ENSMUSG00000134812 (from geneSymbol) uc335zen.1 uc335zen.1 
ENSMUST00000327094.1 ENSMUSG00000134813 ENSMUST00000327094.1 ENSMUSG00000134813 (from geneSymbol) uc335zfn.1 uc335zfn.1 
ENSMUST00000327096.1 ENSMUSG00000134814 ENSMUST00000327096.1 ENSMUSG00000134814 (from geneSymbol) uc335zfp.1 uc335zfp.1 
ENSMUST00000327097.1 ENSMUSG00000134815 ENSMUST00000327097.1 ENSMUSG00000134815 (from geneSymbol) uc335zfq.1 uc335zfq.1 
ENSMUST00000327098.1 ENSMUSG00000134816 ENSMUST00000327098.1 ENSMUSG00000134816 (from geneSymbol) uc335zfr.1 uc335zfr.1 
ENSMUST00000327099.1 ENSMUSG00000134817 ENSMUST00000327099.1 ENSMUSG00000134817 (from geneSymbol) uc335zfs.1 uc335zfs.1 
ENSMUST00000327100.1 ENSMUSG00000134818 ENSMUST00000327100.1 ENSMUSG00000134818 (from geneSymbol) uc335zft.1 uc335zft.1 
ENSMUST00000327103.1 ENSMUSG00000134819 ENSMUST00000327103.1 ENSMUSG00000134819 (from geneSymbol) uc335zfw.1 uc335zfw.1 
ENSMUST00000327119.1 ENSMUSG00000134820 ENSMUST00000327119.1 ENSMUSG00000134820 (from geneSymbol) uc335zgm.1 uc335zgm.1 
ENSMUST00000327134.1 Gm12159 ENSMUST00000327134.1 Gm12159 (from geneSymbol) AK041275 uc335zhb.1 uc335zhb.1 
ENSMUST00000327144.1 ENSMUSG00000134821 ENSMUST00000327144.1 ENSMUSG00000134821 (from geneSymbol) uc335zhl.1 uc335zhl.1 
ENSMUST00000327148.1 ENSMUSG00000134822 ENSMUST00000327148.1 ENSMUSG00000134822 (from geneSymbol) uc335zhp.1 uc335zhp.1 
ENSMUST00000327150.1 ENSMUSG00000134823 ENSMUST00000327150.1 ENSMUSG00000134823 (from geneSymbol) uc335zhr.1 uc335zhr.1 
ENSMUST00000327151.1 ENSMUSG00000134824 ENSMUST00000327151.1 ENSMUSG00000134824 (from geneSymbol) uc335zhs.1 uc335zhs.1 
ENSMUST00000327152.1 ENSMUSG00000134825 ENSMUST00000327152.1 ENSMUSG00000134825 (from geneSymbol) uc335zht.1 uc335zht.1 
ENSMUST00000327156.1 ENSMUSG00000134826 ENSMUST00000327156.1 ENSMUSG00000134826 (from geneSymbol) uc335zhx.1 uc335zhx.1 
ENSMUST00000327159.1 ENSMUSG00000134827 ENSMUST00000327159.1 ENSMUSG00000134827 (from geneSymbol) uc335zia.1 uc335zia.1 
ENSMUST00000327166.1 ENSMUSG00000134828 ENSMUST00000327166.1 ENSMUSG00000134828 (from geneSymbol) uc335zih.1 uc335zih.1 
ENSMUST00000327187.1 Gm48844 ENSMUST00000327187.1 Gm48844 (from geneSymbol) uc335zjc.1 uc335zjc.1 
ENSMUST00000327190.1 ENSMUSG00000134829 ENSMUST00000327190.1 ENSMUSG00000134829 (from geneSymbol) uc335zjf.1 uc335zjf.1 
ENSMUST00000327191.1 ENSMUSG00000134830 ENSMUST00000327191.1 ENSMUSG00000134830 (from geneSymbol) uc335zjg.1 uc335zjg.1 
ENSMUST00000327203.1 ENSMUSG00000134831 ENSMUST00000327203.1 ENSMUSG00000134831 (from geneSymbol) uc335zjs.1 uc335zjs.1 
ENSMUST00000327212.1 ENSMUSG00000134832 ENSMUST00000327212.1 ENSMUSG00000134832 (from geneSymbol) uc335zkb.1 uc335zkb.1 
ENSMUST00000327213.1 ENSMUSG00000134833 ENSMUST00000327213.1 ENSMUSG00000134833 (from geneSymbol) uc335zkc.1 uc335zkc.1 
ENSMUST00000327216.1 ENSMUSG00000134834 ENSMUST00000327216.1 ENSMUSG00000134834 (from geneSymbol) uc335zkf.1 uc335zkf.1 
ENSMUST00000327219.1 ENSMUSG00000134835 ENSMUST00000327219.1 ENSMUSG00000134835 (from geneSymbol) uc335zki.1 uc335zki.1 
ENSMUST00000327220.1 ENSMUSG00000134836 ENSMUST00000327220.1 ENSMUSG00000134836 (from geneSymbol) uc335zkj.1 uc335zkj.1 
ENSMUST00000327221.1 ENSMUSG00000134837 ENSMUST00000327221.1 ENSMUSG00000134837 (from geneSymbol) uc335zkk.1 uc335zkk.1 
ENSMUST00000327222.1 ENSMUSG00000134838 ENSMUST00000327222.1 ENSMUSG00000134838 (from geneSymbol) uc335zkl.1 uc335zkl.1 
ENSMUST00000327223.1 ENSMUSG00000134839 ENSMUST00000327223.1 ENSMUSG00000134839 (from geneSymbol) AK019555 uc335zkm.1 uc335zkm.1 
ENSMUST00000327236.1 ENSMUSG00000134840 ENSMUST00000327236.1 ENSMUSG00000134840 (from geneSymbol) BC038885 uc335zkx.1 uc335zkx.1 
ENSMUST00000327241.1 ENSMUSG00000134841 ENSMUST00000327241.1 ENSMUSG00000134841 (from geneSymbol) uc335zla.1 uc335zla.1 
ENSMUST00000327249.1 ENSMUSG00000134842 ENSMUST00000327249.1 ENSMUSG00000134842 (from geneSymbol) uc335zli.1 uc335zli.1 
ENSMUST00000327251.1 ENSMUSG00000134843 ENSMUST00000327251.1 ENSMUSG00000134843 (from geneSymbol) uc335zlk.1 uc335zlk.1 
ENSMUST00000327252.1 Gm30459 ENSMUST00000327252.1 Gm30459 (from geneSymbol) AK140552 uc335zll.1 uc335zll.1 
ENSMUST00000327253.1 ENSMUSG00000134844 ENSMUST00000327253.1 ENSMUSG00000134844 (from geneSymbol) uc335zlm.1 uc335zlm.1 
ENSMUST00000327254.1 ENSMUSG00000134845 ENSMUST00000327254.1 ENSMUSG00000134845 (from geneSymbol) uc335zln.1 uc335zln.1 
ENSMUST00000327258.1 ENSMUSG00000134846 ENSMUST00000327258.1 ENSMUSG00000134846 (from geneSymbol) uc335zlr.1 uc335zlr.1 
ENSMUST00000327270.1 Gm12873 ENSMUST00000327270.1 Gm12873 (from geneSymbol) uc335zmd.1 uc335zmd.1 
ENSMUST00000327274.1 ENSMUSG00000134848 ENSMUST00000327274.1 ENSMUSG00000134848 (from geneSymbol) uc335zmh.1 uc335zmh.1 
ENSMUST00000327276.1 ENSMUSG00000134849 ENSMUST00000327276.1 ENSMUSG00000134849 (from geneSymbol) uc335zmj.1 uc335zmj.1 
ENSMUST00000327282.1 Gm3924 ENSMUST00000327282.1 Gm3924 (from geneSymbol) uc335zmp.1 uc335zmp.1 
ENSMUST00000327285.1 ENSMUSG00000134850 ENSMUST00000327285.1 ENSMUSG00000134850 (from geneSymbol) uc335zms.1 uc335zms.1 
ENSMUST00000327286.1 ENSMUSG00000134851 ENSMUST00000327286.1 ENSMUSG00000134851 (from geneSymbol) uc335zmt.1 uc335zmt.1 
ENSMUST00000327291.1 ENSMUSG00000134852 ENSMUST00000327291.1 ENSMUSG00000134852 (from geneSymbol) uc335zmy.1 uc335zmy.1 
ENSMUST00000327292.1 ENSMUSG00000134853 ENSMUST00000327292.1 ENSMUSG00000134853 (from geneSymbol) uc335zmz.1 uc335zmz.1 
ENSMUST00000327304.1 ENSMUSG00000134854 ENSMUST00000327304.1 ENSMUSG00000134854 (from geneSymbol) uc335znl.1 uc335znl.1 
ENSMUST00000327306.1 ENSMUSG00000134855 ENSMUST00000327306.1 ENSMUSG00000134855 (from geneSymbol) AK006600 uc335znn.1 uc335znn.1 
ENSMUST00000327308.1 ENSMUSG00000134856 ENSMUST00000327308.1 ENSMUSG00000134856 (from geneSymbol) uc335znp.1 uc335znp.1 
ENSMUST00000327309.1 ENSMUSG00000134857 ENSMUST00000327309.1 ENSMUSG00000134857 (from geneSymbol) uc335znq.1 uc335znq.1 
ENSMUST00000327311.1 ENSMUSG00000134858 ENSMUST00000327311.1 ENSMUSG00000134858 (from geneSymbol) uc335zns.1 uc335zns.1 
ENSMUST00000327313.1 ENSMUSG00000134859 ENSMUST00000327313.1 ENSMUSG00000134859 (from geneSymbol) LF198635 uc335znu.1 uc335znu.1 
ENSMUST00000327314.1 ENSMUSG00000134860 ENSMUST00000327314.1 ENSMUSG00000134860 (from geneSymbol) uc335znv.1 uc335znv.1 
ENSMUST00000327316.1 ENSMUSG00000134861 ENSMUST00000327316.1 ENSMUSG00000134861 (from geneSymbol) uc335znx.1 uc335znx.1 
ENSMUST00000327318.1 ENSMUSG00000134862 ENSMUST00000327318.1 ENSMUSG00000134862 (from geneSymbol) uc335znz.1 uc335znz.1 
ENSMUST00000327320.1 Gm16497 ENSMUST00000327320.1 Gm16497 (from geneSymbol) uc335zob.1 uc335zob.1 
ENSMUST00000327325.1 ENSMUSG00000134863 ENSMUST00000327325.1 ENSMUSG00000134863 (from geneSymbol) AK047145 uc335zog.1 uc335zog.1 
ENSMUST00000327329.1 ENSMUSG00000134864 ENSMUST00000327329.1 ENSMUSG00000134864 (from geneSymbol) uc335zok.1 uc335zok.1 
ENSMUST00000327335.1 ENSMUSG00000134865 ENSMUST00000327335.1 ENSMUSG00000134865 (from geneSymbol) uc335zoq.1 uc335zoq.1 
ENSMUST00000327336.1 ENSMUSG00000134866 ENSMUST00000327336.1 ENSMUSG00000134866 (from geneSymbol) uc335zor.1 uc335zor.1 
ENSMUST00000327337.1 ENSMUSG00000134867 ENSMUST00000327337.1 ENSMUSG00000134867 (from geneSymbol) uc335zos.1 uc335zos.1 
ENSMUST00000327340.1 ENSMUSG00000134868 ENSMUST00000327340.1 ENSMUSG00000134868 (from geneSymbol) uc335zov.1 uc335zov.1 
ENSMUST00000327346.1 ENSMUSG00000134869 ENSMUST00000327346.1 ENSMUSG00000134869 (from geneSymbol) uc335zpb.1 uc335zpb.1 
ENSMUST00000327348.1 ENSMUSG00000134870 ENSMUST00000327348.1 ENSMUSG00000134870 (from geneSymbol) uc335zpd.1 uc335zpd.1 
ENSMUST00000327350.1 4930598F16Rik ENSMUST00000327350.1 4930598F16Rik (from geneSymbol) AK016410 uc335zpf.1 uc335zpf.1 
ENSMUST00000327359.1 ENSMUSG00000134871 ENSMUST00000327359.1 ENSMUSG00000134871 (from geneSymbol) uc335zpm.1 uc335zpm.1 
ENSMUST00000327361.1 ENSMUSG00000134872 ENSMUST00000327361.1 ENSMUSG00000134872 (from geneSymbol) uc335zpo.1 uc335zpo.1 
ENSMUST00000327362.1 ENSMUSG00000134873 ENSMUST00000327362.1 ENSMUSG00000134873 (from geneSymbol) uc335zpp.1 uc335zpp.1 
ENSMUST00000327370.1 ENSMUSG00000134874 ENSMUST00000327370.1 ENSMUSG00000134874 (from geneSymbol) uc335zpx.1 uc335zpx.1 
ENSMUST00000327377.1 ENSMUSG00000134875 ENSMUST00000327377.1 ENSMUSG00000134875 (from geneSymbol) uc335zqe.1 uc335zqe.1 
ENSMUST00000327378.1 ENSMUSG00000134876 ENSMUST00000327378.1 ENSMUSG00000134876 (from geneSymbol) uc335zqf.1 uc335zqf.1 
ENSMUST00000327379.1 ENSMUSG00000134877 ENSMUST00000327379.1 ENSMUSG00000134877 (from geneSymbol) uc335zqg.1 uc335zqg.1 
ENSMUST00000327382.1 ENSMUSG00000134878 ENSMUST00000327382.1 ENSMUSG00000134878 (from geneSymbol) uc335zqj.1 uc335zqj.1 
ENSMUST00000327385.1 ENSMUSG00000134879 ENSMUST00000327385.1 ENSMUSG00000134879 (from geneSymbol) uc335zqm.1 uc335zqm.1 
ENSMUST00000327388.1 ENSMUSG00000134880 ENSMUST00000327388.1 ENSMUSG00000134880 (from geneSymbol) uc335zqo.1 uc335zqo.1 
ENSMUST00000327389.1 ENSMUSG00000134881 ENSMUST00000327389.1 ENSMUSG00000134881 (from geneSymbol) uc335zqp.1 uc335zqp.1 
ENSMUST00000327390.1 ENSMUSG00000134882 ENSMUST00000327390.1 ENSMUSG00000134882 (from geneSymbol) uc335zqq.1 uc335zqq.1 
ENSMUST00000327391.1 ENSMUSG00000134883 ENSMUST00000327391.1 ENSMUSG00000134883 (from geneSymbol) uc335zqr.1 uc335zqr.1 
ENSMUST00000327432.1 Gm49566 ENSMUST00000327432.1 Gm49566 (from geneSymbol) uc335zsg.1 uc335zsg.1 
ENSMUST00000327434.1 ENSMUSG00000134884 ENSMUST00000327434.1 ENSMUSG00000134884 (from geneSymbol) uc335zsi.1 uc335zsi.1 
ENSMUST00000327435.1 ENSMUSG00000134885 ENSMUST00000327435.1 ENSMUSG00000134885 (from geneSymbol) uc335zsj.1 uc335zsj.1 
ENSMUST00000327440.1 ENSMUSG00000134886 ENSMUST00000327440.1 ENSMUSG00000134886 (from geneSymbol) uc335zso.1 uc335zso.1 
ENSMUST00000327441.1 ENSMUSG00000134887 ENSMUST00000327441.1 ENSMUSG00000134887 (from geneSymbol) uc335zsp.1 uc335zsp.1 
ENSMUST00000327486.1 ENSMUSG00000134888 ENSMUST00000327486.1 ENSMUSG00000134888 (from geneSymbol) uc335ztw.1 uc335ztw.1 
ENSMUST00000327488.1 ENSMUSG00000134889 ENSMUST00000327488.1 ENSMUSG00000134889 (from geneSymbol) uc335zty.1 uc335zty.1 
ENSMUST00000327490.1 ENSMUSG00000134890 ENSMUST00000327490.1 ENSMUSG00000134890 (from geneSymbol) uc335zua.1 uc335zua.1 
ENSMUST00000327491.1 ENSMUSG00000134891 ENSMUST00000327491.1 ENSMUSG00000134891 (from geneSymbol) uc335zub.1 uc335zub.1 
ENSMUST00000327493.1 ENSMUSG00000134892 ENSMUST00000327493.1 ENSMUSG00000134892 (from geneSymbol) uc335zud.1 uc335zud.1 
ENSMUST00000327496.1 ENSMUSG00000134893 ENSMUST00000327496.1 ENSMUSG00000134893 (from geneSymbol) uc335zug.1 uc335zug.1 
ENSMUST00000327497.1 Gm57422 ENSMUST00000327497.1 Gm57422 (from geneSymbol) uc335zuh.1 uc335zuh.1 
ENSMUST00000327507.1 ENSMUSG00000134894 ENSMUST00000327507.1 ENSMUSG00000134894 (from geneSymbol) uc335zur.1 uc335zur.1 
ENSMUST00000327508.1 ENSMUSG00000134895 ENSMUST00000327508.1 ENSMUSG00000134895 (from geneSymbol) uc335zus.1 uc335zus.1 
ENSMUST00000327517.1 ENSMUSG00000134896 ENSMUST00000327517.1 ENSMUSG00000134896 (from geneSymbol) uc335zvb.1 uc335zvb.1 
ENSMUST00000327518.1 Gm36423 ENSMUST00000327518.1 Gm36423 (from geneSymbol) uc335zvc.1 uc335zvc.1 
ENSMUST00000327540.1 ENSMUSG00000134897 ENSMUST00000327540.1 ENSMUSG00000134897 (from geneSymbol) uc335zvy.1 uc335zvy.1 
ENSMUST00000327545.1 ENSMUSG00000134898 ENSMUST00000327545.1 ENSMUSG00000134898 (from geneSymbol) uc335zwd.1 uc335zwd.1 
ENSMUST00000327546.1 ENSMUSG00000134899 ENSMUST00000327546.1 ENSMUSG00000134899 (from geneSymbol) uc335zwe.1 uc335zwe.1 
ENSMUST00000327550.1 Gm32051 ENSMUST00000327550.1 Gm32051 (from geneSymbol) AK051451 uc335zwi.1 uc335zwi.1 
ENSMUST00000327552.1 ENSMUSG00000134900 ENSMUST00000327552.1 ENSMUSG00000134900 (from geneSymbol) uc335zwk.1 uc335zwk.1 
ENSMUST00000327555.1 1700054M17Rik ENSMUST00000327555.1 1700054M17Rik (from geneSymbol) AK006785 uc335zwn.1 uc335zwn.1 
ENSMUST00000327557.1 ENSMUSG00000134901 ENSMUST00000327557.1 ENSMUSG00000134901 (from geneSymbol) uc335zwp.1 uc335zwp.1 
ENSMUST00000327560.1 ENSMUSG00000134903 ENSMUST00000327560.1 ENSMUSG00000134903 (from geneSymbol) uc335zwr.1 uc335zwr.1 
ENSMUST00000327569.1 ENSMUSG00000134904 ENSMUST00000327569.1 ENSMUSG00000134904 (from geneSymbol) uc335zxa.1 uc335zxa.1 
ENSMUST00000327570.1 ENSMUSG00000134905 ENSMUST00000327570.1 ENSMUSG00000134905 (from geneSymbol) uc335zxb.1 uc335zxb.1 
ENSMUST00000327573.1 Gm41452 ENSMUST00000327573.1 Gm41452 (from geneSymbol) uc335zxe.1 uc335zxe.1 
ENSMUST00000327580.1 Gm11749 ENSMUST00000327580.1 Gm11749 (from geneSymbol) uc335zxl.1 uc335zxl.1 
ENSMUST00000327585.1 ENSMUSG00000134906 ENSMUST00000327585.1 ENSMUSG00000134906 (from geneSymbol) uc335zxq.1 uc335zxq.1 
ENSMUST00000327587.1 4930535G08Rik ENSMUST00000327587.1 4930535G08Rik (from geneSymbol) AK019720 uc335zxs.1 uc335zxs.1 
ENSMUST00000327588.1 ENSMUSG00000134907 ENSMUST00000327588.1 ENSMUSG00000134907 (from geneSymbol) uc335zxt.1 uc335zxt.1 
ENSMUST00000327589.1 ENSMUSG00000134908 ENSMUST00000327589.1 ENSMUSG00000134908 (from geneSymbol) uc335zxu.1 uc335zxu.1 
ENSMUST00000327591.1 ENSMUSG00000134909 ENSMUST00000327591.1 ENSMUSG00000134909 (from geneSymbol) uc335zxw.1 uc335zxw.1 
ENSMUST00000327594.1 ENSMUSG00000134910 ENSMUST00000327594.1 ENSMUSG00000134910 (from geneSymbol) uc335zxz.1 uc335zxz.1 
ENSMUST00000327600.1 ENSMUSG00000134911 ENSMUST00000327600.1 ENSMUSG00000134911 (from geneSymbol) uc335zyf.1 uc335zyf.1 
ENSMUST00000327601.1 ENSMUSG00000134912 ENSMUST00000327601.1 ENSMUSG00000134912 (from geneSymbol) uc335zyg.1 uc335zyg.1 
ENSMUST00000327604.1 ENSMUSG00000134913 ENSMUST00000327604.1 ENSMUSG00000134913 (from geneSymbol) uc335zyi.1 uc335zyi.1 
ENSMUST00000327605.1 ENSMUSG00000134914 ENSMUST00000327605.1 ENSMUSG00000134914 (from geneSymbol) uc335zyj.1 uc335zyj.1 
ENSMUST00000327606.1 ENSMUSG00000134915 ENSMUST00000327606.1 ENSMUSG00000134915 (from geneSymbol) uc335zyk.1 uc335zyk.1 
ENSMUST00000327607.1 ENSMUSG00000134916 ENSMUST00000327607.1 ENSMUSG00000134916 (from geneSymbol) uc335zyl.1 uc335zyl.1 
ENSMUST00000327608.1 ENSMUSG00000134917 ENSMUST00000327608.1 ENSMUSG00000134917 (from geneSymbol) uc335zym.1 uc335zym.1 
ENSMUST00000327609.1 ENSMUSG00000134918 ENSMUST00000327609.1 ENSMUSG00000134918 (from geneSymbol) uc335zyn.1 uc335zyn.1 
ENSMUST00000327611.1 Gm33263 ENSMUST00000327611.1 Gm33263 (from geneSymbol) uc335zyp.1 uc335zyp.1 
ENSMUST00000327612.1 Gm13001 ENSMUST00000327612.1 Gm13001 (from geneSymbol) uc335zyq.1 uc335zyq.1 
ENSMUST00000327619.1 Gm47396 ENSMUST00000327619.1 Gm47396 (from geneSymbol) uc335zyx.1 uc335zyx.1 
ENSMUST00000327620.1 ENSMUSG00000134919 ENSMUST00000327620.1 ENSMUSG00000134919 (from geneSymbol) uc335zyy.1 uc335zyy.1 
ENSMUST00000327621.1 ENSMUSG00000134920 ENSMUST00000327621.1 ENSMUSG00000134920 (from geneSymbol) uc335zyz.1 uc335zyz.1 
ENSMUST00000327623.1 ENSMUSG00000134921 ENSMUST00000327623.1 ENSMUSG00000134921 (from geneSymbol) uc335zzb.1 uc335zzb.1 
ENSMUST00000327625.1 ENSMUSG00000134922 ENSMUST00000327625.1 ENSMUSG00000134922 (from geneSymbol) uc335zzd.1 uc335zzd.1 
ENSMUST00000327626.1 ENSMUSG00000134923 ENSMUST00000327626.1 ENSMUSG00000134923 (from geneSymbol) uc335zze.1 uc335zze.1 
ENSMUST00000327627.1 ENSMUSG00000134924 ENSMUST00000327627.1 ENSMUSG00000134924 (from geneSymbol) uc335zzf.1 uc335zzf.1 
ENSMUST00000327630.1 ENSMUSG00000134925 ENSMUST00000327630.1 ENSMUSG00000134925 (from geneSymbol) uc335zzi.1 uc335zzi.1 
ENSMUST00000327632.1 ENSMUSG00000134926 ENSMUST00000327632.1 ENSMUSG00000134926 (from geneSymbol) uc335zzk.1 uc335zzk.1 
ENSMUST00000327634.1 ENSMUSG00000134927 ENSMUST00000327634.1 ENSMUSG00000134927 (from geneSymbol) uc335zzm.1 uc335zzm.1 
ENSMUST00000327639.1 ENSMUSG00000134928 ENSMUST00000327639.1 ENSMUSG00000134928 (from geneSymbol) uc335zzr.1 uc335zzr.1 
ENSMUST00000327645.1 ENSMUSG00000134929 ENSMUST00000327645.1 ENSMUSG00000134929 (from geneSymbol) uc335zzx.1 uc335zzx.1 
ENSMUST00000327650.1 ENSMUSG00000134930 ENSMUST00000327650.1 ENSMUSG00000134930 (from geneSymbol) uc336aac.1 uc336aac.1 
ENSMUST00000327652.1 ENSMUSG00000134931 ENSMUST00000327652.1 ENSMUSG00000134931 (from geneSymbol) uc336aad.1 uc336aad.1 
ENSMUST00000327655.1 ENSMUSG00000134932 ENSMUST00000327655.1 ENSMUSG00000134932 (from geneSymbol) uc336aag.1 uc336aag.1 
ENSMUST00000327657.1 ENSMUSG00000134933 ENSMUST00000327657.1 ENSMUSG00000134933 (from geneSymbol) uc336aai.1 uc336aai.1 
ENSMUST00000327658.1 ENSMUSG00000134934 ENSMUST00000327658.1 ENSMUSG00000134934 (from geneSymbol) uc336aaj.1 uc336aaj.1 
ENSMUST00000327661.1 ENSMUSG00000134935 ENSMUST00000327661.1 ENSMUSG00000134935 (from geneSymbol) uc336aam.1 uc336aam.1 
ENSMUST00000327663.1 ENSMUSG00000134936 ENSMUST00000327663.1 ENSMUSG00000134936 (from geneSymbol) uc336aao.1 uc336aao.1 
ENSMUST00000327666.1 ENSMUSG00000134937 ENSMUST00000327666.1 ENSMUSG00000134937 (from geneSymbol) uc336aar.1 uc336aar.1 
ENSMUST00000327684.1 ENSMUSG00000134938 ENSMUST00000327684.1 ENSMUSG00000134938 (from geneSymbol) uc336abj.1 uc336abj.1 
ENSMUST00000327685.1 ENSMUSG00000134939 ENSMUST00000327685.1 ENSMUSG00000134939 (from geneSymbol) uc336abk.1 uc336abk.1 
ENSMUST00000327694.1 ENSMUSG00000134940 ENSMUST00000327694.1 ENSMUSG00000134940 (from geneSymbol) uc336abt.1 uc336abt.1 
ENSMUST00000327695.1 ENSMUSG00000134941 ENSMUST00000327695.1 ENSMUSG00000134941 (from geneSymbol) uc336abu.1 uc336abu.1 
ENSMUST00000327696.1 ENSMUSG00000134942 ENSMUST00000327696.1 ENSMUSG00000134942 (from geneSymbol) uc336abv.1 uc336abv.1 
ENSMUST00000327708.1 ENSMUSG00000134943 ENSMUST00000327708.1 ENSMUSG00000134943 (from geneSymbol) uc336ach.1 uc336ach.1 
ENSMUST00000327720.1 Gm11730 ENSMUST00000327720.1 Gm11730 (from geneSymbol) AK086245 uc336act.1 uc336act.1 
ENSMUST00000327739.1 ENSMUSG00000134944 ENSMUST00000327739.1 ENSMUSG00000134944 (from geneSymbol) uc336adm.1 uc336adm.1 
ENSMUST00000327740.1 ENSMUSG00000134945 ENSMUST00000327740.1 ENSMUSG00000134945 (from geneSymbol) AK085006 uc336adn.1 uc336adn.1 
ENSMUST00000327742.1 ENSMUSG00000134946 ENSMUST00000327742.1 ENSMUSG00000134946 (from geneSymbol) AK085253 uc336adp.1 uc336adp.1 
ENSMUST00000327755.1 ENSMUSG00000134947 ENSMUST00000327755.1 ENSMUSG00000134947 (from geneSymbol) uc336aec.1 uc336aec.1 
ENSMUST00000327760.1 Cdrt4os1 ENSMUST00000327760.1 Cdrt4os1 (from geneSymbol) AK015448 uc336aeh.1 uc336aeh.1 
ENSMUST00000327762.1 ENSMUSG00000134948 ENSMUST00000327762.1 ENSMUSG00000134948 (from geneSymbol) uc336aej.1 uc336aej.1 
ENSMUST00000327766.1 4930433B08Rik ENSMUST00000327766.1 predicted gene, 30667 (from RefSeq NR_166207.1) NR_166207 uc336aen.1 uc336aen.1 
ENSMUST00000327778.1 ENSMUSG00000134949 ENSMUST00000327778.1 ENSMUSG00000134949 (from geneSymbol) uc336aez.1 uc336aez.1 
ENSMUST00000327780.1 ENSMUSG00000134951 ENSMUST00000327780.1 ENSMUSG00000134951 (from geneSymbol) uc336afa.1 uc336afa.1 
ENSMUST00000327782.1 ENSMUSG00000134952 ENSMUST00000327782.1 ENSMUSG00000134952 (from geneSymbol) uc336afc.1 uc336afc.1 
ENSMUST00000327788.1 ENSMUSG00000134953 ENSMUST00000327788.1 ENSMUSG00000134953 (from geneSymbol) uc336afi.1 uc336afi.1 
ENSMUST00000327791.1 ENSMUSG00000134954 ENSMUST00000327791.1 ENSMUSG00000134954 (from geneSymbol) uc336afl.1 uc336afl.1 
ENSMUST00000327792.1 ENSMUSG00000134955 ENSMUST00000327792.1 ENSMUSG00000134955 (from geneSymbol) uc336afm.1 uc336afm.1 
ENSMUST00000327795.1 ENSMUSG00000134956 ENSMUST00000327795.1 ENSMUSG00000134956 (from geneSymbol) uc336afp.1 uc336afp.1 
ENSMUST00000327797.1 ENSMUSG00000134957 ENSMUST00000327797.1 ENSMUSG00000134957 (from geneSymbol) uc336afr.1 uc336afr.1 
ENSMUST00000327798.1 ENSMUSG00000134958 ENSMUST00000327798.1 ENSMUSG00000134958 (from geneSymbol) uc336afs.1 uc336afs.1 
ENSMUST00000327799.1 ENSMUSG00000134959 ENSMUST00000327799.1 ENSMUSG00000134959 (from geneSymbol) uc336aft.1 uc336aft.1 
ENSMUST00000327801.1 ENSMUSG00000134960 ENSMUST00000327801.1 ENSMUSG00000134960 (from geneSymbol) uc336afv.1 uc336afv.1 
ENSMUST00000327804.1 ENSMUSG00000134961 ENSMUST00000327804.1 ENSMUSG00000134961 (from geneSymbol) uc336afy.1 uc336afy.1 
ENSMUST00000327819.1 Gm44071 ENSMUST00000327819.1 Gm44071 (from geneSymbol) AK029641 uc336agn.1 uc336agn.1 
ENSMUST00000327822.1 ENSMUSG00000134962 ENSMUST00000327822.1 ENSMUSG00000134962 (from geneSymbol) uc336agq.1 uc336agq.1 
ENSMUST00000327823.1 ENSMUSG00000134963 ENSMUST00000327823.1 ENSMUSG00000134963 (from geneSymbol) uc336agr.1 uc336agr.1 
ENSMUST00000327824.1 ENSMUSG00000134964 ENSMUST00000327824.1 ENSMUSG00000134964 (from geneSymbol) uc336ags.1 uc336ags.1 
ENSMUST00000327828.1 ENSMUSG00000134965 ENSMUST00000327828.1 ENSMUSG00000134965 (from geneSymbol) uc336agw.1 uc336agw.1 
ENSMUST00000327833.1 Gm807 ENSMUST00000327833.1 Gm807 (from geneSymbol) AK145614 uc336ahb.1 uc336ahb.1 
ENSMUST00000327839.1 ENSMUSG00000134966 ENSMUST00000327839.1 ENSMUSG00000134966 (from geneSymbol) uc336ahh.1 uc336ahh.1 
ENSMUST00000327844.1 Gm45391 ENSMUST00000327844.1 Gm45391 (from geneSymbol) uc336ahm.1 uc336ahm.1 
ENSMUST00000327845.1 ENSMUSG00000134967 ENSMUST00000327845.1 ENSMUSG00000134967 (from geneSymbol) uc336ahn.1 uc336ahn.1 
ENSMUST00000327849.1 Gm44036 ENSMUST00000327849.1 Gm44036 (from geneSymbol) uc336ahr.1 uc336ahr.1 
ENSMUST00000327856.1 4931419H13Rik ENSMUST00000327856.1 4931419H13Rik (from geneSymbol) AK016464 uc336ahy.1 uc336ahy.1 
ENSMUST00000327864.1 ENSMUSG00000134968 ENSMUST00000327864.1 ENSMUSG00000134968 (from geneSymbol) uc336aig.1 uc336aig.1 
ENSMUST00000327865.1 ENSMUSG00000134969 ENSMUST00000327865.1 ENSMUSG00000134969 (from geneSymbol) uc336aih.1 uc336aih.1 
ENSMUST00000327866.1 ENSMUSG00000134970 ENSMUST00000327866.1 ENSMUSG00000134970 (from geneSymbol) uc336aii.1 uc336aii.1 
ENSMUST00000327867.1 ENSMUSG00000134971 ENSMUST00000327867.1 ENSMUSG00000134971 (from geneSymbol) uc336aij.1 uc336aij.1 
ENSMUST00000327871.1 ENSMUSG00000134972 ENSMUST00000327871.1 ENSMUSG00000134972 (from geneSymbol) uc336ain.1 uc336ain.1 
ENSMUST00000327876.1 ENSMUSG00000134973 ENSMUST00000327876.1 ENSMUSG00000134973 (from geneSymbol) uc336ais.1 uc336ais.1 
ENSMUST00000327877.1 ENSMUSG00000134974 ENSMUST00000327877.1 ENSMUSG00000134974 (from geneSymbol) uc336ait.1 uc336ait.1 
ENSMUST00000327884.1 ENSMUSG00000134975 ENSMUST00000327884.1 ENSMUSG00000134975 (from geneSymbol) uc336aja.1 uc336aja.1 
ENSMUST00000327889.1 Gm56537 ENSMUST00000327889.1 Gm56537 (from geneSymbol) uc336ajf.1 uc336ajf.1 
ENSMUST00000327891.1 ENSMUSG00000134976 ENSMUST00000327891.1 ENSMUSG00000134976 (from geneSymbol) uc336ajh.1 uc336ajh.1 
ENSMUST00000327900.1 ENSMUSG00000134977 ENSMUST00000327900.1 ENSMUSG00000134977 (from geneSymbol) uc336ajq.1 uc336ajq.1 
ENSMUST00000327901.1 ENSMUSG00000134978 ENSMUST00000327901.1 ENSMUSG00000134978 (from geneSymbol) uc336ajr.1 uc336ajr.1 
ENSMUST00000327904.1 ENSMUSG00000134979 ENSMUST00000327904.1 ENSMUSG00000134979 (from geneSymbol) uc336aju.1 uc336aju.1 
ENSMUST00000327907.1 ENSMUSG00000134981 ENSMUST00000327907.1 ENSMUSG00000134981 (from geneSymbol) LF198165 uc336ajv.1 uc336ajv.1 
ENSMUST00000327910.1 ENSMUSG00000134982 ENSMUST00000327910.1 ENSMUSG00000134982 (from geneSymbol) uc336ajy.1 uc336ajy.1 
ENSMUST00000327913.1 ENSMUSG00000134983 ENSMUST00000327913.1 ENSMUSG00000134983 (from geneSymbol) uc336akb.1 uc336akb.1 
ENSMUST00000327915.1 ENSMUSG00000134984 ENSMUST00000327915.1 ENSMUSG00000134984 (from geneSymbol) uc336akd.1 uc336akd.1 
ENSMUST00000327916.1 ENSMUSG00000134985 ENSMUST00000327916.1 ENSMUSG00000134985 (from geneSymbol) uc336ake.1 uc336ake.1 
ENSMUST00000327917.1 Gm12637 ENSMUST00000327917.1 Gm12637 (from geneSymbol) uc336akf.1 uc336akf.1 
ENSMUST00000327931.1 ENSMUSG00000134986 ENSMUST00000327931.1 ENSMUSG00000134986 (from geneSymbol) uc336akt.1 uc336akt.1 
ENSMUST00000327935.1 Gm36874 ENSMUST00000327935.1 Gm36874 (from geneSymbol) uc336akx.1 uc336akx.1 
ENSMUST00000327942.1 ENSMUSG00000134987 ENSMUST00000327942.1 ENSMUSG00000134987 (from geneSymbol) uc336ale.1 uc336ale.1 
ENSMUST00000327945.1 ENSMUSG00000134988 ENSMUST00000327945.1 ENSMUSG00000134988 (from geneSymbol) uc336alh.1 uc336alh.1 
ENSMUST00000327955.1 ENSMUSG00000134989 ENSMUST00000327955.1 ENSMUSG00000134989 (from geneSymbol) uc336alq.1 uc336alq.1 
ENSMUST00000327967.1 Gm32793 ENSMUST00000327967.1 Gm32793 (from geneSymbol) uc336amc.1 uc336amc.1 
ENSMUST00000327973.1 Gm56907 ENSMUST00000327973.1 Gm56907 (from geneSymbol) uc336ami.1 uc336ami.1 
ENSMUST00000327987.1 ENSMUSG00000134990 ENSMUST00000327987.1 ENSMUSG00000134990 (from geneSymbol) uc336amw.1 uc336amw.1 
ENSMUST00000327989.1 ENSMUSG00000134991 ENSMUST00000327989.1 ENSMUSG00000134991 (from geneSymbol) uc336amy.1 uc336amy.1 
ENSMUST00000327990.1 ENSMUSG00000134992 ENSMUST00000327990.1 ENSMUSG00000134992 (from geneSymbol) uc336amz.1 uc336amz.1 
ENSMUST00000327991.1 ENSMUSG00000134993 ENSMUST00000327991.1 ENSMUSG00000134993 (from geneSymbol) uc336ana.1 uc336ana.1 
ENSMUST00000327995.1 ENSMUSG00000134994 ENSMUST00000327995.1 ENSMUSG00000134994 (from geneSymbol) uc336ane.1 uc336ane.1 
ENSMUST00000328000.1 ENSMUSG00000134995 ENSMUST00000328000.1 ENSMUSG00000134995 (from geneSymbol) uc336anj.1 uc336anj.1 
ENSMUST00000328005.1 4930442J19Rik ENSMUST00000328005.1 4930442J19Rik (from geneSymbol) AK015363 uc336ano.1 uc336ano.1 
ENSMUST00000328034.1 ENSMUSG00000134996 ENSMUST00000328034.1 ENSMUSG00000134996 (from geneSymbol) uc336aor.1 uc336aor.1 
ENSMUST00000328037.1 ENSMUSG00000134997 ENSMUST00000328037.1 ENSMUSG00000134997 (from geneSymbol) uc336aou.1 uc336aou.1 
ENSMUST00000328038.1 ENSMUSG00000134998 ENSMUST00000328038.1 ENSMUSG00000134998 (from geneSymbol) uc336aov.1 uc336aov.1 
ENSMUST00000328041.1 ENSMUSG00000134999 ENSMUST00000328041.1 ENSMUSG00000134999 (from geneSymbol) uc336aoy.1 uc336aoy.1 
ENSMUST00000328042.1 ENSMUSG00000135000 ENSMUST00000328042.1 ENSMUSG00000135000 (from geneSymbol) uc336aoz.1 uc336aoz.1 
ENSMUST00000328043.1 ENSMUSG00000135001 ENSMUST00000328043.1 ENSMUSG00000135001 (from geneSymbol) uc336apa.1 uc336apa.1 
ENSMUST00000328044.1 ENSMUSG00000135002 ENSMUST00000328044.1 ENSMUSG00000135002 (from geneSymbol) uc336apb.1 uc336apb.1 
ENSMUST00000328046.1 1810059H22Rik ENSMUST00000328046.1 1810059H22Rik (from geneSymbol) AK079377 uc336apd.1 uc336apd.1 
ENSMUST00000328066.1 ENSMUSG00000135003 ENSMUST00000328066.1 ENSMUSG00000135003 (from geneSymbol) uc336apv.1 uc336apv.1 
ENSMUST00000328083.1 ENSMUSG00000135004 ENSMUST00000328083.1 ENSMUSG00000135004 (from geneSymbol) uc336aqm.1 uc336aqm.1 
ENSMUST00000328085.1 ENSMUSG00000135005 ENSMUST00000328085.1 ENSMUSG00000135005 (from geneSymbol) uc336aqo.1 uc336aqo.1 
ENSMUST00000328088.1 ENSMUSG00000135006 ENSMUST00000328088.1 ENSMUSG00000135006 (from geneSymbol) uc336aqr.1 uc336aqr.1 
ENSMUST00000328090.1 ENSMUSG00000135008 ENSMUST00000328090.1 ENSMUSG00000135008 (from geneSymbol) uc336aqs.1 uc336aqs.1 
ENSMUST00000328091.1 ENSMUSG00000135009 ENSMUST00000328091.1 ENSMUSG00000135009 (from geneSymbol) uc336aqt.1 uc336aqt.1 
ENSMUST00000328095.1 ENSMUSG00000135010 ENSMUST00000328095.1 ENSMUSG00000135010 (from geneSymbol) uc336aqx.1 uc336aqx.1 
ENSMUST00000328096.1 ENSMUSG00000135011 ENSMUST00000328096.1 ENSMUSG00000135011 (from geneSymbol) uc336aqy.1 uc336aqy.1 
ENSMUST00000328098.1 ENSMUSG00000135012 ENSMUST00000328098.1 ENSMUSG00000135012 (from geneSymbol) uc336ara.1 uc336ara.1 
ENSMUST00000328100.1 ENSMUSG00000135013 ENSMUST00000328100.1 ENSMUSG00000135013 (from geneSymbol) uc336arb.1 uc336arb.1 
ENSMUST00000328102.1 ENSMUSG00000135014 ENSMUST00000328102.1 ENSMUSG00000135014 (from geneSymbol) uc336ard.1 uc336ard.1 
ENSMUST00000328103.1 ENSMUSG00000135015 ENSMUST00000328103.1 ENSMUSG00000135015 (from geneSymbol) uc336are.1 uc336are.1 
ENSMUST00000328109.1 ENSMUSG00000135016 ENSMUST00000328109.1 ENSMUSG00000135016 (from geneSymbol) uc336ark.1 uc336ark.1 
ENSMUST00000328110.1 ENSMUSG00000135017 ENSMUST00000328110.1 ENSMUSG00000135017 (from geneSymbol) uc336arl.1 uc336arl.1 
ENSMUST00000328111.1 ENSMUSG00000135018 ENSMUST00000328111.1 ENSMUSG00000135018 (from geneSymbol) uc336arm.1 uc336arm.1 
ENSMUST00000328112.1 ENSMUSG00000135019 ENSMUST00000328112.1 ENSMUSG00000135019 (from geneSymbol) uc336arn.1 uc336arn.1 
ENSMUST00000328113.1 ENSMUSG00000135020 ENSMUST00000328113.1 ENSMUSG00000135020 (from geneSymbol) uc336aro.1 uc336aro.1 
ENSMUST00000328129.1 Gm32261 ENSMUST00000328129.1 Gm32261 (from geneSymbol) uc336ase.1 uc336ase.1 
ENSMUST00000328140.1 ENSMUSG00000135021 ENSMUST00000328140.1 ENSMUSG00000135021 (from geneSymbol) uc336asp.1 uc336asp.1 
ENSMUST00000328141.1 ENSMUSG00000135022 ENSMUST00000328141.1 ENSMUSG00000135022 (from geneSymbol) uc336asq.1 uc336asq.1 
ENSMUST00000328154.1 Gm47962 ENSMUST00000328154.1 Gm47962 (from geneSymbol) uc336atd.1 uc336atd.1 
ENSMUST00000328163.1 Gm56541 ENSMUST00000328163.1 Gm56541 (from geneSymbol) uc336atm.1 uc336atm.1 
ENSMUST00000328166.1 ENSMUSG00000135023 ENSMUST00000328166.1 ENSMUSG00000135023 (from geneSymbol) uc336atp.1 uc336atp.1 
ENSMUST00000328169.1 ENSMUSG00000135024 ENSMUST00000328169.1 ENSMUSG00000135024 (from geneSymbol) uc336ats.1 uc336ats.1 
ENSMUST00000328174.1 ENSMUSG00000135025 ENSMUST00000328174.1 ENSMUSG00000135025 (from geneSymbol) uc336atx.1 uc336atx.1 
ENSMUST00000328176.1 D930019O06Rik ENSMUST00000328176.1 D930019O06Rik (from geneSymbol) uc336atz.1 uc336atz.1 
ENSMUST00000328177.1 Gm50397 ENSMUST00000328177.1 Gm50397 (from geneSymbol) uc336aua.1 uc336aua.1 
ENSMUST00000328179.1 ENSMUSG00000135026 ENSMUST00000328179.1 ENSMUSG00000135026 (from geneSymbol) uc336auc.1 uc336auc.1 
ENSMUST00000328181.1 ENSMUSG00000135027 ENSMUST00000328181.1 ENSMUSG00000135027 (from geneSymbol) uc336aue.1 uc336aue.1 
ENSMUST00000328182.1 ENSMUSG00000135028 ENSMUST00000328182.1 ENSMUSG00000135028 (from geneSymbol) uc336auf.1 uc336auf.1 
ENSMUST00000328186.1 ENSMUSG00000135029 ENSMUST00000328186.1 ENSMUSG00000135029 (from geneSymbol) uc336auj.1 uc336auj.1 
ENSMUST00000328191.1 ENSMUSG00000135030 ENSMUST00000328191.1 ENSMUSG00000135030 (from geneSymbol) uc336auo.1 uc336auo.1 
ENSMUST00000328192.1 Gm4633 ENSMUST00000328192.1 Gm4633 (from geneSymbol) AK044286 uc336aup.1 uc336aup.1 
ENSMUST00000328205.1 Gm41715 ENSMUST00000328205.1 Gm41715 (from geneSymbol) uc336avc.1 uc336avc.1 
ENSMUST00000328210.1 ENSMUSG00000135031 ENSMUST00000328210.1 ENSMUSG00000135031 (from geneSymbol) DQ723735 uc336avh.1 uc336avh.1 
ENSMUST00000328215.1 ENSMUSG00000135032 ENSMUST00000328215.1 ENSMUSG00000135032 (from geneSymbol) uc336avm.1 uc336avm.1 
ENSMUST00000328217.1 ENSMUSG00000135033 ENSMUST00000328217.1 ENSMUSG00000135033 (from geneSymbol) uc336avo.1 uc336avo.1 
ENSMUST00000328221.1 Gm41244 ENSMUST00000328221.1 Gm41244 (from geneSymbol) uc336avs.1 uc336avs.1 
ENSMUST00000328238.1 ENSMUSG00000135034 ENSMUST00000328238.1 ENSMUSG00000135034 (from geneSymbol) uc336awj.1 uc336awj.1 
ENSMUST00000328240.1 ENSMUSG00000135035 ENSMUST00000328240.1 ENSMUSG00000135035 (from geneSymbol) uc336awl.1 uc336awl.1 
ENSMUST00000328241.1 ENSMUSG00000135036 ENSMUST00000328241.1 ENSMUSG00000135036 (from geneSymbol) uc336awm.1 uc336awm.1 
ENSMUST00000328243.1 ENSMUSG00000135037 ENSMUST00000328243.1 ENSMUSG00000135037 (from geneSymbol) uc336awo.1 uc336awo.1 
ENSMUST00000328247.1 AY702102 ENSMUST00000328247.1 cDNA sequence AY702102 (from RefSeq NR_131974.1) NR_131974 uc336aws.1 uc336aws.1 
ENSMUST00000328248.1 ENSMUSG00000135039 ENSMUST00000328248.1 ENSMUSG00000135039 (from geneSymbol) uc336awt.1 uc336awt.1 
ENSMUST00000328249.1 ENSMUSG00000135040 ENSMUST00000328249.1 ENSMUSG00000135040 (from geneSymbol) uc336awu.1 uc336awu.1 
ENSMUST00000328250.1 Gm56630 ENSMUST00000328250.1 Gm56630 (from geneSymbol) uc336awv.1 uc336awv.1 
ENSMUST00000328257.1 ENSMUSG00000135041 ENSMUST00000328257.1 ENSMUSG00000135041 (from geneSymbol) uc336axc.1 uc336axc.1 
ENSMUST00000328260.1 ENSMUSG00000135042 ENSMUST00000328260.1 ENSMUSG00000135042 (from geneSymbol) uc336axf.1 uc336axf.1 
ENSMUST00000328265.1 ENSMUSG00000135043 ENSMUST00000328265.1 ENSMUSG00000135043 (from geneSymbol) uc336axk.1 uc336axk.1 
ENSMUST00000328267.1 ENSMUSG00000135044 ENSMUST00000328267.1 ENSMUSG00000135044 (from geneSymbol) uc336axm.1 uc336axm.1 
ENSMUST00000328268.1 Gm33926 ENSMUST00000328268.1 Gm33926 (from geneSymbol) uc336axn.1 uc336axn.1 
ENSMUST00000328308.1 ENSMUSG00000135045 ENSMUST00000328308.1 ENSMUSG00000135045 (from geneSymbol) uc336aza.1 uc336aza.1 
ENSMUST00000328318.1 ENSMUSG00000135047 ENSMUST00000328318.1 ENSMUSG00000135047 (from geneSymbol) uc336azj.1 uc336azj.1 
ENSMUST00000328324.1 ENSMUSG00000135048 ENSMUST00000328324.1 ENSMUSG00000135048 (from geneSymbol) AK015602 uc336azp.1 uc336azp.1 
ENSMUST00000328346.1 ENSMUSG00000135049 ENSMUST00000328346.1 ENSMUSG00000135049 (from geneSymbol) uc336bal.1 uc336bal.1 
ENSMUST00000328347.1 ENSMUSG00000135050 ENSMUST00000328347.1 ENSMUSG00000135050 (from geneSymbol) uc336bam.1 uc336bam.1 
ENSMUST00000328351.1 Gm52885 ENSMUST00000328351.1 Gm52885 (from geneSymbol) uc336baq.1 uc336baq.1 
ENSMUST00000328354.1 ENSMUSG00000135052 ENSMUST00000328354.1 ENSMUSG00000135052 (from geneSymbol) uc336bat.1 uc336bat.1 
ENSMUST00000328355.1 ENSMUSG00000135053 ENSMUST00000328355.1 ENSMUSG00000135053 (from geneSymbol) uc336bau.1 uc336bau.1 
ENSMUST00000328356.1 ENSMUSG00000135054 ENSMUST00000328356.1 ENSMUSG00000135054 (from geneSymbol) uc336bav.1 uc336bav.1 
ENSMUST00000328357.1 ENSMUSG00000135055 ENSMUST00000328357.1 ENSMUSG00000135055 (from geneSymbol) uc336baw.1 uc336baw.1 
ENSMUST00000328358.1 Gm3521 ENSMUST00000328358.1 Gm3521 (from geneSymbol) uc336bax.1 uc336bax.1 
ENSMUST00000328361.1 Gm47782 ENSMUST00000328361.1 Gm47782 (from geneSymbol) uc336bba.1 uc336bba.1 
ENSMUST00000328362.1 ENSMUSG00000135057 ENSMUST00000328362.1 ENSMUSG00000135057 (from geneSymbol) uc336bbb.1 uc336bbb.1 
ENSMUST00000328364.1 ENSMUSG00000135059 ENSMUST00000328364.1 ENSMUSG00000135059 (from geneSymbol) uc336bbc.1 uc336bbc.1 
ENSMUST00000328366.1 ENSMUSG00000135060 ENSMUST00000328366.1 ENSMUSG00000135060 (from geneSymbol) uc336bbe.1 uc336bbe.1 
ENSMUST00000328368.1 Gm46815 ENSMUST00000328368.1 predicted gene, 46815, transcript variant 1 (from RefSeq NR_176009.1) NR_176009 uc336bbg.1 uc336bbg.1 
ENSMUST00000328373.1 ENSMUSG00000135061 ENSMUST00000328373.1 ENSMUSG00000135061 (from geneSymbol) uc336bbl.1 uc336bbl.1 
ENSMUST00000328380.1 1700110I01Rik ENSMUST00000328380.1 1700110I01Rik (from geneSymbol) AK006024 uc336bbs.1 uc336bbs.1 
ENSMUST00000328396.1 ENSMUSG00000135062 ENSMUST00000328396.1 ENSMUSG00000135062 (from geneSymbol) uc336bci.1 uc336bci.1 
ENSMUST00000328397.1 ENSMUSG00000135063 ENSMUST00000328397.1 ENSMUSG00000135063 (from geneSymbol) uc336bcj.1 uc336bcj.1 
ENSMUST00000328398.1 ENSMUSG00000135064 ENSMUST00000328398.1 ENSMUSG00000135064 (from geneSymbol) uc336bck.1 uc336bck.1 
ENSMUST00000328402.1 Gm36495 ENSMUST00000328402.1 Gm36495 (from geneSymbol) uc336bco.1 uc336bco.1 
ENSMUST00000328406.1 ENSMUSG00000135065 ENSMUST00000328406.1 ENSMUSG00000135065 (from geneSymbol) uc336bcs.1 uc336bcs.1 
ENSMUST00000328408.1 ENSMUSG00000135066 ENSMUST00000328408.1 ENSMUSG00000135066 (from geneSymbol) uc336bcu.1 uc336bcu.1 
ENSMUST00000328415.1 4930448I18Rik ENSMUST00000328415.1 4930448I18Rik (from geneSymbol) AK015420 uc336bdb.1 uc336bdb.1 
ENSMUST00000328418.1 ENSMUSG00000135067 ENSMUST00000328418.1 ENSMUSG00000135067 (from geneSymbol) AK139943 uc336bde.1 uc336bde.1 
ENSMUST00000328446.1 ENSMUSG00000135068 ENSMUST00000328446.1 ENSMUSG00000135068 (from geneSymbol) uc336beg.1 uc336beg.1 
ENSMUST00000328449.1 ENSMUSG00000135069 ENSMUST00000328449.1 ENSMUSG00000135069 (from geneSymbol) uc336bej.1 uc336bej.1 
ENSMUST00000328451.1 ENSMUSG00000135070 ENSMUST00000328451.1 ENSMUSG00000135070 (from geneSymbol) uc336bel.1 uc336bel.1 
ENSMUST00000328452.1 ENSMUSG00000135071 ENSMUST00000328452.1 ENSMUSG00000135071 (from geneSymbol) uc336bem.1 uc336bem.1 
ENSMUST00000328460.1 ENSMUSG00000135072 ENSMUST00000328460.1 ENSMUSG00000135072 (from geneSymbol) uc336beu.1 uc336beu.1 
ENSMUST00000328465.1 ENSMUSG00000135073 ENSMUST00000328465.1 ENSMUSG00000135073 (from geneSymbol) uc336bez.1 uc336bez.1 
ENSMUST00000328467.1 ENSMUSG00000135074 ENSMUST00000328467.1 ENSMUSG00000135074 (from geneSymbol) uc336bfb.1 uc336bfb.1 
ENSMUST00000328468.1 ENSMUSG00000135075 ENSMUST00000328468.1 ENSMUSG00000135075 (from geneSymbol) uc336bfc.1 uc336bfc.1 
ENSMUST00000328469.1 Gm20383 ENSMUST00000328469.1 Gm20383 (from geneSymbol) AK138645 uc336bfd.1 uc336bfd.1 
ENSMUST00000328473.1 ENSMUSG00000135076 ENSMUST00000328473.1 ENSMUSG00000135076 (from geneSymbol) uc336bfh.1 uc336bfh.1 
ENSMUST00000328501.1 ENSMUSG00000135077 ENSMUST00000328501.1 ENSMUSG00000135077 (from geneSymbol) uc336bgj.1 uc336bgj.1 
ENSMUST00000328502.1 1700120C14Rik ENSMUST00000328502.1 1700120C14Rik (from geneSymbol) AK007210 uc336bgk.1 uc336bgk.1 
ENSMUST00000328541.1 ENSMUSG00000135078 ENSMUST00000328541.1 ENSMUSG00000135078 (from geneSymbol) uc336bhx.1 uc336bhx.1 
ENSMUST00000328547.1 Gm49793 ENSMUST00000328547.1 Gm49793 (from geneSymbol) uc336bid.1 uc336bid.1 
ENSMUST00000328549.1 ENSMUSG00000135079 ENSMUST00000328549.1 ENSMUSG00000135079 (from geneSymbol) uc336bif.1 uc336bif.1 
ENSMUST00000328550.1 ENSMUSG00000135080 ENSMUST00000328550.1 ENSMUSG00000135080 (from geneSymbol) uc336big.1 uc336big.1 
ENSMUST00000328551.1 ENSMUSG00000135081 ENSMUST00000328551.1 ENSMUSG00000135081 (from geneSymbol) uc336bih.1 uc336bih.1 
ENSMUST00000328552.1 ENSMUSG00000135082 ENSMUST00000328552.1 ENSMUSG00000135082 (from geneSymbol) uc336bii.1 uc336bii.1 
ENSMUST00000328553.1 ENSMUSG00000135083 ENSMUST00000328553.1 ENSMUSG00000135083 (from geneSymbol) uc336bij.1 uc336bij.1 
ENSMUST00000328555.1 ENSMUSG00000135085 ENSMUST00000328555.1 ENSMUSG00000135085 (from geneSymbol) uc336bik.1 uc336bik.1 
ENSMUST00000328572.1 ENSMUSG00000135087 ENSMUST00000328572.1 ENSMUSG00000135087 (from geneSymbol) uc336bja.1 uc336bja.1 
ENSMUST00000328573.1 ENSMUSG00000135088 ENSMUST00000328573.1 ENSMUSG00000135088 (from geneSymbol) uc336bjb.1 uc336bjb.1 
ENSMUST00000328575.1 ENSMUSG00000135089 ENSMUST00000328575.1 ENSMUSG00000135089 (from geneSymbol) uc336bjd.1 uc336bjd.1 
ENSMUST00000328583.1 ENSMUSG00000135090 ENSMUST00000328583.1 ENSMUSG00000135090 (from geneSymbol) uc336bjl.1 uc336bjl.1 
ENSMUST00000328584.1 ENSMUSG00000135091 ENSMUST00000328584.1 ENSMUSG00000135091 (from geneSymbol) uc336bjm.1 uc336bjm.1 
ENSMUST00000328585.1 ENSMUSG00000135092 ENSMUST00000328585.1 ENSMUSG00000135092 (from geneSymbol) uc336bjn.1 uc336bjn.1 
ENSMUST00000328586.1 Gm13584 ENSMUST00000328586.1 Gm13584 (from geneSymbol) uc336bjo.1 uc336bjo.1 
ENSMUST00000328588.1 ENSMUSG00000135093 ENSMUST00000328588.1 ENSMUSG00000135093 (from geneSymbol) uc336bjq.1 uc336bjq.1 
ENSMUST00000328592.1 ENSMUSG00000135094 ENSMUST00000328592.1 ENSMUSG00000135094 (from geneSymbol) uc336bju.1 uc336bju.1 
ENSMUST00000328595.1 ENSMUSG00000135095 ENSMUST00000328595.1 ENSMUSG00000135095 (from geneSymbol) uc336bjx.1 uc336bjx.1 
ENSMUST00000328596.1 ENSMUSG00000135096 ENSMUST00000328596.1 ENSMUSG00000135096 (from geneSymbol) uc336bjy.1 uc336bjy.1 
ENSMUST00000328597.1 ENSMUSG00000135097 ENSMUST00000328597.1 ENSMUSG00000135097 (from geneSymbol) uc336bjz.1 uc336bjz.1 
ENSMUST00000328598.1 ENSMUSG00000135098 ENSMUST00000328598.1 ENSMUSG00000135098 (from geneSymbol) uc336bka.1 uc336bka.1 
ENSMUST00000328599.1 ENSMUSG00000135099 ENSMUST00000328599.1 ENSMUSG00000135099 (from geneSymbol) uc336bkb.1 uc336bkb.1 
ENSMUST00000328600.1 Gm13656 ENSMUST00000328600.1 Gm13656 (from geneSymbol) uc336bkc.1 uc336bkc.1 
ENSMUST00000328601.1 ENSMUSG00000135100 ENSMUST00000328601.1 ENSMUSG00000135100 (from geneSymbol) uc336bkd.1 uc336bkd.1 
ENSMUST00000328602.1 Gm17690 ENSMUST00000328602.1 Gm17690 (from geneSymbol) AK142077 uc336bke.1 uc336bke.1 
ENSMUST00000328604.1 ENSMUSG00000135101 ENSMUST00000328604.1 ENSMUSG00000135101 (from geneSymbol) uc336bkg.1 uc336bkg.1 
ENSMUST00000328607.1 Gm15133 ENSMUST00000328607.1 Gm15133 (from geneSymbol) KY468156 uc336bkj.1 uc336bkj.1 
ENSMUST00000328623.1 Gm17188 ENSMUST00000328623.1 Gm17188 (from geneSymbol) AK015236 uc336bkz.1 uc336bkz.1 
ENSMUST00000328628.1 ENSMUSG00000135102 ENSMUST00000328628.1 ENSMUSG00000135102 (from geneSymbol) uc336ble.1 uc336ble.1 
ENSMUST00000328629.1 Gm32738 ENSMUST00000328629.1 predicted gene, 32738 (from RefSeq NR_168344.1) NR_168344 uc336blf.1 uc336blf.1 
ENSMUST00000328631.1 ENSMUSG00000135104 ENSMUST00000328631.1 ENSMUSG00000135104 (from geneSymbol) uc336blh.1 uc336blh.1 
ENSMUST00000328633.1 ENSMUSG00000135105 ENSMUST00000328633.1 ENSMUSG00000135105 (from geneSymbol) uc336blj.1 uc336blj.1 
ENSMUST00000328634.1 ENSMUSG00000135106 ENSMUST00000328634.1 ENSMUSG00000135106 (from geneSymbol) uc336blk.1 uc336blk.1 
ENSMUST00000328636.1 ENSMUSG00000135107 ENSMUST00000328636.1 ENSMUSG00000135107 (from geneSymbol) uc336blm.1 uc336blm.1 
ENSMUST00000328637.1 Gm49067 ENSMUST00000328637.1 Gm49067 (from geneSymbol) uc336bln.1 uc336bln.1 
ENSMUST00000328642.1 ENSMUSG00000135108 ENSMUST00000328642.1 ENSMUSG00000135108 (from geneSymbol) uc336bls.1 uc336bls.1 
ENSMUST00000328692.1 ENSMUSG00000135109 ENSMUST00000328692.1 ENSMUSG00000135109 (from geneSymbol) uc336bno.1 uc336bno.1 
ENSMUST00000328693.1 ENSMUSG00000135110 ENSMUST00000328693.1 ENSMUSG00000135110 (from geneSymbol) uc336bnp.1 uc336bnp.1 
ENSMUST00000328702.1 Gm44202 ENSMUST00000328702.1 Gm44202 (from geneSymbol) uc336bny.1 uc336bny.1 
ENSMUST00000328709.1 ENSMUSG00000135111 ENSMUST00000328709.1 ENSMUSG00000135111 (from geneSymbol) uc336bof.1 uc336bof.1 
ENSMUST00000328710.1 ENSMUSG00000135112 ENSMUST00000328710.1 ENSMUSG00000135112 (from geneSymbol) uc336bog.1 uc336bog.1 
ENSMUST00000328713.1 ENSMUSG00000135113 ENSMUST00000328713.1 ENSMUSG00000135113 (from geneSymbol) uc336boj.1 uc336boj.1 
ENSMUST00000328714.1 ENSMUSG00000135114 ENSMUST00000328714.1 ENSMUSG00000135114 (from geneSymbol) uc336bok.1 uc336bok.1 
ENSMUST00000328715.1 ENSMUSG00000135115 ENSMUST00000328715.1 ENSMUSG00000135115 (from geneSymbol) uc336bol.1 uc336bol.1 
ENSMUST00000328718.1 ENSMUSG00000135116 ENSMUST00000328718.1 ENSMUSG00000135116 (from geneSymbol) uc336boo.1 uc336boo.1 
ENSMUST00000328720.1 ENSMUSG00000135117 ENSMUST00000328720.1 ENSMUSG00000135117 (from geneSymbol) uc336boq.1 uc336boq.1 
ENSMUST00000328722.1 ENSMUSG00000135118 ENSMUST00000328722.1 ENSMUSG00000135118 (from geneSymbol) uc336bos.1 uc336bos.1 
ENSMUST00000328725.1 ENSMUSG00000135119 ENSMUST00000328725.1 ENSMUSG00000135119 (from geneSymbol) uc336bov.1 uc336bov.1 
ENSMUST00000328728.1 ENSMUSG00000135120 ENSMUST00000328728.1 ENSMUSG00000135120 (from geneSymbol) uc336boy.1 uc336boy.1 
ENSMUST00000328729.1 ENSMUSG00000135121 ENSMUST00000328729.1 ENSMUSG00000135121 (from geneSymbol) uc336boz.1 uc336boz.1 
ENSMUST00000328731.1 ENSMUSG00000135122 ENSMUST00000328731.1 ENSMUSG00000135122 (from geneSymbol) uc336bpb.1 uc336bpb.1 
ENSMUST00000328732.1 ENSMUSG00000135123 ENSMUST00000328732.1 ENSMUSG00000135123 (from geneSymbol) uc336bpc.1 uc336bpc.1 
ENSMUST00000328733.1 ENSMUSG00000135124 ENSMUST00000328733.1 ENSMUSG00000135124 (from geneSymbol) uc336bpd.1 uc336bpd.1 
ENSMUST00000328735.1 ENSMUSG00000135125 ENSMUST00000328735.1 ENSMUSG00000135125 (from geneSymbol) uc336bpf.1 uc336bpf.1 
ENSMUST00000328738.1 ENSMUSG00000135126 ENSMUST00000328738.1 ENSMUSG00000135126 (from geneSymbol) uc336bpg.1 uc336bpg.1 
ENSMUST00000328745.1 Gm15409 ENSMUST00000328745.1 Gm15409 (from geneSymbol) uc336bpm.1 uc336bpm.1 
ENSMUST00000328750.1 ENSMUSG00000135127 ENSMUST00000328750.1 ENSMUSG00000135127 (from geneSymbol) uc336bpr.1 uc336bpr.1 
ENSMUST00000328752.1 ENSMUSG00000135128 ENSMUST00000328752.1 ENSMUSG00000135128 (from geneSymbol) uc336bpt.1 uc336bpt.1 
ENSMUST00000328753.1 ENSMUSG00000135129 ENSMUST00000328753.1 ENSMUSG00000135129 (from geneSymbol) uc336bpu.1 uc336bpu.1 
ENSMUST00000328774.1 B430105G09Rik ENSMUST00000328774.1 B430105G09Rik (from geneSymbol) uc336bqp.1 uc336bqp.1 
ENSMUST00000328780.1 ENSMUSG00000135130 ENSMUST00000328780.1 ENSMUSG00000135130 (from geneSymbol) uc336bqv.1 uc336bqv.1 
ENSMUST00000328790.1 ENSMUSG00000135131 ENSMUST00000328790.1 ENSMUSG00000135131 (from geneSymbol) uc336brf.1 uc336brf.1 
ENSMUST00000328793.1 ENSMUSG00000135132 ENSMUST00000328793.1 ENSMUSG00000135132 (from geneSymbol) uc336bri.1 uc336bri.1 
ENSMUST00000328794.1 Gm40761 ENSMUST00000328794.1 Gm40761 (from geneSymbol) AK142676 uc336brj.1 uc336brj.1 
ENSMUST00000328795.1 ENSMUSG00000135133 ENSMUST00000328795.1 ENSMUSG00000135133 (from geneSymbol) uc336brk.1 uc336brk.1 
ENSMUST00000328796.1 ENSMUSG00000135134 ENSMUST00000328796.1 ENSMUSG00000135134 (from geneSymbol) uc336brl.1 uc336brl.1 
ENSMUST00000328800.1 Gm48242 ENSMUST00000328800.1 Gm48242 (from geneSymbol) uc336brp.1 uc336brp.1 
ENSMUST00000328806.1 ENSMUSG00000135136 ENSMUST00000328806.1 ENSMUSG00000135136 (from geneSymbol) uc336bru.1 uc336bru.1 
ENSMUST00000328809.1 ENSMUSG00000135137 ENSMUST00000328809.1 ENSMUSG00000135137 (from geneSymbol) uc336brx.1 uc336brx.1 
ENSMUST00000328811.1 E030042O20Rik ENSMUST00000328811.1 E030042O20Rik (from geneSymbol) uc336brz.1 uc336brz.1 
ENSMUST00000328818.1 ENSMUSG00000135138 ENSMUST00000328818.1 ENSMUSG00000135138 (from geneSymbol) uc336bsg.1 uc336bsg.1 
ENSMUST00000328820.1 ENSMUSG00000135140 ENSMUST00000328820.1 ENSMUSG00000135140 (from geneSymbol) uc336bsh.1 uc336bsh.1 
ENSMUST00000328823.1 Gm15875 ENSMUST00000328823.1 Gm15875 (from geneSymbol) uc336bsk.1 uc336bsk.1 
ENSMUST00000328824.1 ENSMUSG00000135141 ENSMUST00000328824.1 ENSMUSG00000135141 (from geneSymbol) uc336bsl.1 uc336bsl.1 
ENSMUST00000328826.1 ENSMUSG00000135142 ENSMUST00000328826.1 ENSMUSG00000135142 (from geneSymbol) uc336bsn.1 uc336bsn.1 
ENSMUST00000328828.1 ENSMUSG00000135143 ENSMUST00000328828.1 ENSMUSG00000135143 (from geneSymbol) uc336bsp.1 uc336bsp.1 
ENSMUST00000328829.1 ENSMUSG00000135144 ENSMUST00000328829.1 ENSMUSG00000135144 (from geneSymbol) uc336bsq.1 uc336bsq.1 
ENSMUST00000328831.1 ENSMUSG00000135145 ENSMUST00000328831.1 ENSMUSG00000135145 (from geneSymbol) uc336bss.1 uc336bss.1 
ENSMUST00000328835.1 ENSMUSG00000135146 ENSMUST00000328835.1 ENSMUSG00000135146 (from geneSymbol) AK135986 uc336bsw.1 uc336bsw.1 
ENSMUST00000328837.1 ENSMUSG00000135147 ENSMUST00000328837.1 ENSMUSG00000135147 (from geneSymbol) uc336bsy.1 uc336bsy.1 
ENSMUST00000328842.1 ENSMUSG00000135148 ENSMUST00000328842.1 ENSMUSG00000135148 (from geneSymbol) uc336btd.1 uc336btd.1 
ENSMUST00000328843.1 ENSMUSG00000135149 ENSMUST00000328843.1 ENSMUSG00000135149 (from geneSymbol) uc336bte.1 uc336bte.1 
ENSMUST00000328845.1 ENSMUSG00000135150 ENSMUST00000328845.1 ENSMUSG00000135150 (from geneSymbol) uc336btg.1 uc336btg.1 
ENSMUST00000328848.1 ENSMUSG00000135151 ENSMUST00000328848.1 ENSMUSG00000135151 (from geneSymbol) uc336btj.1 uc336btj.1 
ENSMUST00000328849.1 ENSMUSG00000135152 ENSMUST00000328849.1 ENSMUSG00000135152 (from geneSymbol) uc336btk.1 uc336btk.1 
ENSMUST00000328850.1 ENSMUSG00000135153 ENSMUST00000328850.1 ENSMUSG00000135153 (from geneSymbol) uc336btl.1 uc336btl.1 
ENSMUST00000328854.1 Gm32291 ENSMUST00000328854.1 Gm32291 (from geneSymbol) uc336btp.1 uc336btp.1 
ENSMUST00000328862.1 ENSMUSG00000135155 ENSMUST00000328862.1 ENSMUSG00000135155 (from geneSymbol) uc336btx.1 uc336btx.1 
ENSMUST00000328863.1 ENSMUSG00000135156 ENSMUST00000328863.1 ENSMUSG00000135156 (from geneSymbol) uc336bty.1 uc336bty.1 
ENSMUST00000328864.1 ENSMUSG00000135157 ENSMUST00000328864.1 ENSMUSG00000135157 (from geneSymbol) uc336btz.1 uc336btz.1 
ENSMUST00000328866.1 ENSMUSG00000135158 ENSMUST00000328866.1 ENSMUSG00000135158 (from geneSymbol) uc336bub.1 uc336bub.1 
ENSMUST00000328868.1 ENSMUSG00000135159 ENSMUST00000328868.1 ENSMUSG00000135159 (from geneSymbol) uc336buc.1 uc336buc.1 
ENSMUST00000328869.1 ENSMUSG00000135160 ENSMUST00000328869.1 ENSMUSG00000135160 (from geneSymbol) uc336bud.1 uc336bud.1 
ENSMUST00000328870.1 ENSMUSG00000135161 ENSMUST00000328870.1 ENSMUSG00000135161 (from geneSymbol) uc336bue.1 uc336bue.1 
ENSMUST00000328871.1 ENSMUSG00000135162 ENSMUST00000328871.1 ENSMUSG00000135162 (from geneSymbol) uc336buf.1 uc336buf.1 
ENSMUST00000328872.1 ENSMUSG00000135163 ENSMUST00000328872.1 ENSMUSG00000135163 (from geneSymbol) uc336bug.1 uc336bug.1 
ENSMUST00000328873.1 Gm57161 ENSMUST00000328873.1 Gm57161 (from geneSymbol) uc336buh.1 uc336buh.1 
ENSMUST00000328877.1 ENSMUSG00000135164 ENSMUST00000328877.1 ENSMUSG00000135164 (from geneSymbol) AK011483 uc336bul.1 uc336bul.1 
ENSMUST00000328891.1 ENSMUSG00000135165 ENSMUST00000328891.1 ENSMUSG00000135165 (from geneSymbol) uc336buz.1 uc336buz.1 
ENSMUST00000328892.1 4921504A21Rik ENSMUST00000328892.1 4921504A21Rik (from geneSymbol) AK046351 uc336bva.1 uc336bva.1 
ENSMUST00000328918.1 ENSMUSG00000135166 ENSMUST00000328918.1 ENSMUSG00000135166 (from geneSymbol) uc336bwa.1 uc336bwa.1 
ENSMUST00000328920.1 Rbfaos ENSMUST00000328920.1 Rbfaos (from geneSymbol) AK141205 uc336bwc.1 uc336bwc.1 
ENSMUST00000328921.1 ENSMUSG00000135167 ENSMUST00000328921.1 ENSMUSG00000135167 (from geneSymbol) uc336bwd.1 uc336bwd.1 
ENSMUST00000328922.1 ENSMUSG00000135168 ENSMUST00000328922.1 ENSMUSG00000135168 (from geneSymbol) uc336bwe.1 uc336bwe.1 
ENSMUST00000328923.1 ENSMUSG00000135169 ENSMUST00000328923.1 ENSMUSG00000135169 (from geneSymbol) uc336bwf.1 uc336bwf.1 
ENSMUST00000328926.1 ENSMUSG00000135170 ENSMUST00000328926.1 ENSMUSG00000135170 (from geneSymbol) uc336bwi.1 uc336bwi.1 
ENSMUST00000328927.1 ENSMUSG00000135171 ENSMUST00000328927.1 ENSMUSG00000135171 (from geneSymbol) uc336bwj.1 uc336bwj.1 
ENSMUST00000328928.1 ENSMUSG00000135172 ENSMUST00000328928.1 ENSMUSG00000135172 (from geneSymbol) uc336bwk.1 uc336bwk.1 
ENSMUST00000328929.1 ENSMUSG00000135173 ENSMUST00000328929.1 ENSMUSG00000135173 (from geneSymbol) uc336bwl.1 uc336bwl.1 
ENSMUST00000328930.1 ENSMUSG00000135174 ENSMUST00000328930.1 ENSMUSG00000135174 (from geneSymbol) uc336bwm.1 uc336bwm.1 
ENSMUST00000328931.1 ENSMUSG00000135175 ENSMUST00000328931.1 ENSMUSG00000135175 (from geneSymbol) uc336bwn.1 uc336bwn.1 
ENSMUST00000328932.1 ENSMUSG00000135176 ENSMUST00000328932.1 ENSMUSG00000135176 (from geneSymbol) uc336bwo.1 uc336bwo.1 
ENSMUST00000328933.1 ENSMUSG00000135177 ENSMUST00000328933.1 ENSMUSG00000135177 (from geneSymbol) uc336bwp.1 uc336bwp.1 
ENSMUST00000328936.1 ENSMUSG00000135178 ENSMUST00000328936.1 ENSMUSG00000135178 (from geneSymbol) uc336bws.1 uc336bws.1 
ENSMUST00000328940.1 ENSMUSG00000135179 ENSMUST00000328940.1 ENSMUSG00000135179 (from geneSymbol) uc336bww.1 uc336bww.1 
ENSMUST00000328941.1 ENSMUSG00000135180 ENSMUST00000328941.1 ENSMUSG00000135180 (from geneSymbol) uc336bwx.1 uc336bwx.1 
ENSMUST00000328942.1 ENSMUSG00000135181 ENSMUST00000328942.1 ENSMUSG00000135181 (from geneSymbol) uc336bwy.1 uc336bwy.1 
ENSMUST00000328943.1 ENSMUSG00000135182 ENSMUST00000328943.1 ENSMUSG00000135182 (from geneSymbol) uc336bwz.1 uc336bwz.1 
ENSMUST00000328944.1 ENSMUSG00000135183 ENSMUST00000328944.1 ENSMUSG00000135183 (from geneSymbol) uc336bxa.1 uc336bxa.1 
ENSMUST00000328947.1 ENSMUSG00000135184 ENSMUST00000328947.1 ENSMUSG00000135184 (from geneSymbol) uc336bxd.1 uc336bxd.1 
ENSMUST00000328950.1 ENSMUSG00000135185 ENSMUST00000328950.1 ENSMUSG00000135185 (from geneSymbol) uc336bxg.1 uc336bxg.1 
ENSMUST00000328951.1 ENSMUSG00000135186 ENSMUST00000328951.1 ENSMUSG00000135186 (from geneSymbol) uc336bxh.1 uc336bxh.1 
ENSMUST00000328952.1 ENSMUSG00000135187 ENSMUST00000328952.1 ENSMUSG00000135187 (from geneSymbol) uc336bxi.1 uc336bxi.1 
ENSMUST00000328955.1 ENSMUSG00000135188 ENSMUST00000328955.1 ENSMUSG00000135188 (from geneSymbol) uc336bxl.1 uc336bxl.1 
ENSMUST00000328958.1 ENSMUSG00000135189 ENSMUST00000328958.1 ENSMUSG00000135189 (from geneSymbol) uc336bxo.1 uc336bxo.1 
ENSMUST00000328959.1 ENSMUSG00000135190 ENSMUST00000328959.1 ENSMUSG00000135190 (from geneSymbol) uc336bxp.1 uc336bxp.1 
ENSMUST00000328965.1 ENSMUSG00000135191 ENSMUST00000328965.1 ENSMUSG00000135191 (from geneSymbol) uc336bxv.1 uc336bxv.1 
ENSMUST00000328966.1 ENSMUSG00000135192 ENSMUST00000328966.1 ENSMUSG00000135192 (from geneSymbol) uc336bxw.1 uc336bxw.1 
ENSMUST00000328968.1 ENSMUSG00000135193 ENSMUST00000328968.1 ENSMUSG00000135193 (from geneSymbol) uc336bxy.1 uc336bxy.1 
ENSMUST00000328969.1 ENSMUSG00000135194 ENSMUST00000328969.1 ENSMUSG00000135194 (from geneSymbol) uc336bxz.1 uc336bxz.1 
ENSMUST00000328970.1 Gm19723 ENSMUST00000328970.1 predicted gene, 19723 (from RefSeq NR_153658.1) NR_153658 uc336bya.1 uc336bya.1 
ENSMUST00000328975.1 ENSMUSG00000135196 ENSMUST00000328975.1 ENSMUSG00000135196 (from geneSymbol) uc336byf.1 uc336byf.1 
ENSMUST00000328981.1 ENSMUSG00000135197 ENSMUST00000328981.1 ENSMUSG00000135197 (from geneSymbol) uc336byl.1 uc336byl.1 
ENSMUST00000328991.1 ENSMUSG00000135198 ENSMUST00000328991.1 ENSMUSG00000135198 (from geneSymbol) uc336byv.1 uc336byv.1 
ENSMUST00000328992.1 ENSMUSG00000135199 ENSMUST00000328992.1 ENSMUSG00000135199 (from geneSymbol) uc336byw.1 uc336byw.1 
ENSMUST00000328994.1 ENSMUSG00000135200 ENSMUST00000328994.1 ENSMUSG00000135200 (from geneSymbol) uc336byy.1 uc336byy.1 
ENSMUST00000328998.1 Gm15736 ENSMUST00000328998.1 Gm15736 (from geneSymbol) uc336bzc.1 uc336bzc.1 
ENSMUST00000328999.1 Gm9884 ENSMUST00000328999.1 predicted gene 9884 (from RefSeq NR_169046.1) NR_169046 uc336bzd.1 uc336bzd.1 
ENSMUST00000329000.1 ENSMUSG00000135202 ENSMUST00000329000.1 ENSMUSG00000135202 (from geneSymbol) uc336bze.1 uc336bze.1 
ENSMUST00000329002.1 ENSMUSG00000135203 ENSMUST00000329002.1 ENSMUSG00000135203 (from geneSymbol) uc336bzg.1 uc336bzg.1 
ENSMUST00000329009.1 Gm33838 ENSMUST00000329009.1 Gm33838 (from geneSymbol) uc336bzn.1 uc336bzn.1 
ENSMUST00000329023.1 ENSMUSG00000135204 ENSMUST00000329023.1 ENSMUSG00000135204 (from geneSymbol) uc336cab.1 uc336cab.1 
ENSMUST00000329024.1 ENSMUSG00000135205 ENSMUST00000329024.1 ENSMUSG00000135205 (from geneSymbol) uc336cac.1 uc336cac.1 
ENSMUST00000329026.1 ENSMUSG00000135206 ENSMUST00000329026.1 ENSMUSG00000135206 (from geneSymbol) uc336cae.1 uc336cae.1 
ENSMUST00000329034.1 ENSMUSG00000135207 ENSMUST00000329034.1 ENSMUSG00000135207 (from geneSymbol) uc336cam.1 uc336cam.1 
ENSMUST00000329035.1 ENSMUSG00000135208 ENSMUST00000329035.1 ENSMUSG00000135208 (from geneSymbol) uc336can.1 uc336can.1 
ENSMUST00000329038.1 ENSMUSG00000135209 ENSMUST00000329038.1 ENSMUSG00000135209 (from geneSymbol) uc336caq.1 uc336caq.1 
ENSMUST00000329041.1 ENSMUSG00000135210 ENSMUST00000329041.1 ENSMUSG00000135210 (from geneSymbol) uc336cat.1 uc336cat.1 
ENSMUST00000329047.1 ENSMUSG00000135211 ENSMUST00000329047.1 ENSMUSG00000135211 (from geneSymbol) uc336cay.1 uc336cay.1 
ENSMUST00000329048.1 ENSMUSG00000135212 ENSMUST00000329048.1 ENSMUSG00000135212 (from geneSymbol) uc336caz.1 uc336caz.1 
ENSMUST00000329049.1 ENSMUSG00000135213 ENSMUST00000329049.1 ENSMUSG00000135213 (from geneSymbol) uc336cba.1 uc336cba.1 
ENSMUST00000329050.1 ENSMUSG00000135214 ENSMUST00000329050.1 ENSMUSG00000135214 (from geneSymbol) uc336cbb.1 uc336cbb.1 
ENSMUST00000329052.1 ENSMUSG00000135215 ENSMUST00000329052.1 ENSMUSG00000135215 (from geneSymbol) uc336cbd.1 uc336cbd.1 
ENSMUST00000329065.1 ENSMUSG00000135216 ENSMUST00000329065.1 ENSMUSG00000135216 (from geneSymbol) LF201818 uc336cbq.1 uc336cbq.1 
ENSMUST00000329066.1 ENSMUSG00000135217 ENSMUST00000329066.1 ENSMUSG00000135217 (from geneSymbol) uc336cbr.1 uc336cbr.1 
ENSMUST00000329067.1 ENSMUSG00000135218 ENSMUST00000329067.1 ENSMUSG00000135218 (from geneSymbol) uc336cbs.1 uc336cbs.1 
ENSMUST00000329069.1 ENSMUSG00000135219 ENSMUST00000329069.1 ENSMUSG00000135219 (from geneSymbol) uc336cbu.1 uc336cbu.1 
ENSMUST00000329072.1 ENSMUSG00000135220 ENSMUST00000329072.1 ENSMUSG00000135220 (from geneSymbol) AK019791 uc336cbx.1 uc336cbx.1 
ENSMUST00000329073.1 ENSMUSG00000135221 ENSMUST00000329073.1 ENSMUSG00000135221 (from geneSymbol) uc336cby.1 uc336cby.1 
ENSMUST00000329074.1 ENSMUSG00000135222 ENSMUST00000329074.1 ENSMUSG00000135222 (from geneSymbol) uc336cbz.1 uc336cbz.1 
ENSMUST00000329075.1 ENSMUSG00000135223 ENSMUST00000329075.1 ENSMUSG00000135223 (from geneSymbol) uc336cca.1 uc336cca.1 
ENSMUST00000329080.1 ENSMUSG00000135224 ENSMUST00000329080.1 ENSMUSG00000135224 (from geneSymbol) uc336ccf.1 uc336ccf.1 
ENSMUST00000329089.1 ENSMUSG00000135225 ENSMUST00000329089.1 ENSMUSG00000135225 (from geneSymbol) uc336cco.1 uc336cco.1 
ENSMUST00000329090.1 ENSMUSG00000135226 ENSMUST00000329090.1 ENSMUSG00000135226 (from geneSymbol) uc336ccp.1 uc336ccp.1 
ENSMUST00000329092.1 ENSMUSG00000135227 ENSMUST00000329092.1 ENSMUSG00000135227 (from geneSymbol) uc336ccr.1 uc336ccr.1 
ENSMUST00000329094.1 ENSMUSG00000135228 ENSMUST00000329094.1 ENSMUSG00000135228 (from geneSymbol) uc336cct.1 uc336cct.1 
ENSMUST00000329095.1 ENSMUSG00000135229 ENSMUST00000329095.1 ENSMUSG00000135229 (from geneSymbol) uc336ccu.1 uc336ccu.1 
ENSMUST00000329098.1 ENSMUSG00000135230 ENSMUST00000329098.1 ENSMUSG00000135230 (from geneSymbol) uc336ccx.1 uc336ccx.1 
ENSMUST00000329100.1 ENSMUSG00000135231 ENSMUST00000329100.1 ENSMUSG00000135231 (from geneSymbol) uc336ccz.1 uc336ccz.1 
ENSMUST00000329104.1 ENSMUSG00000135232 ENSMUST00000329104.1 ENSMUSG00000135232 (from geneSymbol) uc336cdd.1 uc336cdd.1 
ENSMUST00000329106.1 Gm26594 ENSMUST00000329106.1 Gm26594 (from geneSymbol) AK133135 uc336cdf.1 uc336cdf.1 
ENSMUST00000329109.1 ENSMUSG00000135233 ENSMUST00000329109.1 ENSMUSG00000135233 (from geneSymbol) uc336cdi.1 uc336cdi.1 
ENSMUST00000329110.1 ENSMUSG00000135234 ENSMUST00000329110.1 ENSMUSG00000135234 (from geneSymbol) uc336cdj.1 uc336cdj.1 
ENSMUST00000329111.1 ENSMUSG00000135235 ENSMUST00000329111.1 ENSMUSG00000135235 (from geneSymbol) uc336cdk.1 uc336cdk.1 
ENSMUST00000329113.1 9530080O11Rik ENSMUST00000329113.1 9530080O11Rik (from geneSymbol) AK079280 uc336cdm.1 uc336cdm.1 
ENSMUST00000329124.1 ENSMUSG00000135236 ENSMUST00000329124.1 ENSMUSG00000135236 (from geneSymbol) uc336cdx.1 uc336cdx.1 
ENSMUST00000329130.1 ENSMUSG00000135237 ENSMUST00000329130.1 ENSMUSG00000135237 (from geneSymbol) uc336ced.1 uc336ced.1 
ENSMUST00000329140.1 ENSMUSG00000135238 ENSMUST00000329140.1 ENSMUSG00000135238 (from geneSymbol) uc336cen.1 uc336cen.1 
ENSMUST00000329147.1 4930432O09Rik ENSMUST00000329147.1 4930432O09Rik (from geneSymbol) uc336ceu.1 uc336ceu.1 
ENSMUST00000329157.1 ENSMUSG00000135239 ENSMUST00000329157.1 ENSMUSG00000135239 (from geneSymbol) uc336cfe.1 uc336cfe.1 
ENSMUST00000329158.1 ENSMUSG00000135240 ENSMUST00000329158.1 ENSMUSG00000135240 (from geneSymbol) uc336cff.1 uc336cff.1 
ENSMUST00000329161.1 ENSMUSG00000135241 ENSMUST00000329161.1 ENSMUSG00000135241 (from geneSymbol) uc336cfi.1 uc336cfi.1 
ENSMUST00000329162.1 ENSMUSG00000135242 ENSMUST00000329162.1 ENSMUSG00000135242 (from geneSymbol) uc336cfj.1 uc336cfj.1 
ENSMUST00000329173.1 4930513O06Rik ENSMUST00000329173.1 4930513O06Rik (from geneSymbol) AK015788 uc336cfu.1 uc336cfu.1 
ENSMUST00000329175.1 Gm19554 ENSMUST00000329175.1 Gm19554 (from geneSymbol) AK043332 uc336cfw.1 uc336cfw.1 
ENSMUST00000329179.1 Gm31592 ENSMUST00000329179.1 Gm31592 (from geneSymbol) AK034176 uc336cga.1 uc336cga.1 
ENSMUST00000329184.1 ENSMUSG00000135243 ENSMUST00000329184.1 ENSMUSG00000135243 (from geneSymbol) uc336cgf.1 uc336cgf.1 
ENSMUST00000329185.1 ENSMUSG00000135244 ENSMUST00000329185.1 ENSMUSG00000135244 (from geneSymbol) uc336cgg.1 uc336cgg.1 
ENSMUST00000329186.1 ENSMUSG00000135245 ENSMUST00000329186.1 ENSMUSG00000135245 (from geneSymbol) uc336cgh.1 uc336cgh.1 
ENSMUST00000329187.1 ENSMUSG00000135246 ENSMUST00000329187.1 ENSMUSG00000135246 (from geneSymbol) uc336cgi.1 uc336cgi.1 
ENSMUST00000329189.1 ENSMUSG00000135247 ENSMUST00000329189.1 ENSMUSG00000135247 (from geneSymbol) uc336cgk.1 uc336cgk.1 
ENSMUST00000329190.1 ENSMUSG00000135248 ENSMUST00000329190.1 ENSMUSG00000135248 (from geneSymbol) uc336cgl.1 uc336cgl.1 
ENSMUST00000329196.1 Gm13530 ENSMUST00000329196.1 Gm13530 (from geneSymbol) uc336cgq.1 uc336cgq.1 
ENSMUST00000329204.1 ENSMUSG00000135250 ENSMUST00000329204.1 ENSMUSG00000135250 (from geneSymbol) AK077067 uc336cgy.1 uc336cgy.1 
ENSMUST00000329206.1 Gm33206 ENSMUST00000329206.1 Gm33206 (from geneSymbol) uc336cha.1 uc336cha.1 
ENSMUST00000329213.1 ENSMUSG00000135251 ENSMUST00000329213.1 ENSMUSG00000135251 (from geneSymbol) DQ540134 uc336chh.1 uc336chh.1 
ENSMUST00000329216.1 ENSMUSG00000135252 ENSMUST00000329216.1 ENSMUSG00000135252 (from geneSymbol) uc336chk.1 uc336chk.1 
ENSMUST00000329218.1 ENSMUSG00000135253 ENSMUST00000329218.1 ENSMUSG00000135253 (from geneSymbol) uc336chm.1 uc336chm.1 
ENSMUST00000329220.1 Gm30932 ENSMUST00000329220.1 Gm30932 (from geneSymbol) uc336cho.1 uc336cho.1 
ENSMUST00000329226.1 ENSMUSG00000135254 ENSMUST00000329226.1 ENSMUSG00000135254 (from geneSymbol) uc336chu.1 uc336chu.1 
ENSMUST00000329228.1 ENSMUSG00000135255 ENSMUST00000329228.1 ENSMUSG00000135255 (from geneSymbol) uc336chw.1 uc336chw.1 
ENSMUST00000329232.1 ENSMUSG00000135256 ENSMUST00000329232.1 ENSMUSG00000135256 (from geneSymbol) AK143764 uc336cia.1 uc336cia.1 
ENSMUST00000329234.1 ENSMUSG00000135257 ENSMUST00000329234.1 ENSMUSG00000135257 (from geneSymbol) uc336cic.1 uc336cic.1 
ENSMUST00000329235.1 ENSMUSG00000135258 ENSMUST00000329235.1 ENSMUSG00000135258 (from geneSymbol) uc336cid.1 uc336cid.1 
ENSMUST00000329239.1 ENSMUSG00000135259 ENSMUST00000329239.1 ENSMUSG00000135259 (from geneSymbol) uc336cih.1 uc336cih.1 
ENSMUST00000329245.1 Gm44753 ENSMUST00000329245.1 Gm44753 (from geneSymbol) uc336cin.1 uc336cin.1 
ENSMUST00000329263.1 ENSMUSG00000135260 ENSMUST00000329263.1 ENSMUSG00000135260 (from geneSymbol) uc336cje.1 uc336cje.1 
ENSMUST00000329264.1 ENSMUSG00000135261 ENSMUST00000329264.1 ENSMUSG00000135261 (from geneSymbol) uc336cjf.1 uc336cjf.1 
ENSMUST00000329267.1 4930590L14Rik ENSMUST00000329267.1 4930590L14Rik (from geneSymbol) AK016381 uc336cji.1 uc336cji.1 
ENSMUST00000329269.1 ENSMUSG00000135262 ENSMUST00000329269.1 ENSMUSG00000135262 (from geneSymbol) uc336cjk.1 uc336cjk.1 
ENSMUST00000329283.1 ENSMUSG00000135264 ENSMUST00000329283.1 ENSMUSG00000135264 (from geneSymbol) uc336cjv.1 uc336cjv.1 
ENSMUST00000329290.1 ENSMUSG00000135265 ENSMUST00000329290.1 ENSMUSG00000135265 (from geneSymbol) BC031451 uc336ckc.1 uc336ckc.1 
ENSMUST00000329294.1 ENSMUSG00000135266 ENSMUST00000329294.1 ENSMUSG00000135266 (from geneSymbol) uc336ckg.1 uc336ckg.1 
ENSMUST00000329295.1 ENSMUSG00000135267 ENSMUST00000329295.1 ENSMUSG00000135267 (from geneSymbol) uc336ckh.1 uc336ckh.1 
ENSMUST00000329296.1 ENSMUSG00000135268 ENSMUST00000329296.1 ENSMUSG00000135268 (from geneSymbol) uc336cki.1 uc336cki.1 
ENSMUST00000329308.1 ENSMUSG00000135269 ENSMUST00000329308.1 ENSMUSG00000135269 (from geneSymbol) uc336cku.1 uc336cku.1 
ENSMUST00000329309.1 ENSMUSG00000135270 ENSMUST00000329309.1 ENSMUSG00000135270 (from geneSymbol) uc336ckv.1 uc336ckv.1 
ENSMUST00000329312.1 ENSMUSG00000135271 ENSMUST00000329312.1 ENSMUSG00000135271 (from geneSymbol) uc336cky.1 uc336cky.1 
ENSMUST00000329315.1 ENSMUSG00000135272 ENSMUST00000329315.1 ENSMUSG00000135272 (from geneSymbol) uc336clb.1 uc336clb.1 
ENSMUST00000329317.1 ENSMUSG00000135273 ENSMUST00000329317.1 ENSMUSG00000135273 (from geneSymbol) uc336cld.1 uc336cld.1 
ENSMUST00000329318.1 ENSMUSG00000135274 ENSMUST00000329318.1 ENSMUSG00000135274 (from geneSymbol) uc336cle.1 uc336cle.1 
ENSMUST00000329321.1 ENSMUSG00000135276 ENSMUST00000329321.1 ENSMUSG00000135276 (from geneSymbol) AK007019 uc336clg.1 uc336clg.1 
ENSMUST00000329325.1 ENSMUSG00000135277 ENSMUST00000329325.1 ENSMUSG00000135277 (from geneSymbol) uc336clk.1 uc336clk.1 
ENSMUST00000329326.1 ENSMUSG00000135278 ENSMUST00000329326.1 ENSMUSG00000135278 (from geneSymbol) uc336cll.1 uc336cll.1 
ENSMUST00000329331.1 ENSMUSG00000135279 ENSMUST00000329331.1 ENSMUSG00000135279 (from geneSymbol) uc336clq.1 uc336clq.1 
ENSMUST00000329333.1 ENSMUSG00000135280 ENSMUST00000329333.1 ENSMUSG00000135280 (from geneSymbol) AK043151 uc336cls.1 uc336cls.1 
ENSMUST00000329334.1 ENSMUSG00000135281 ENSMUST00000329334.1 ENSMUSG00000135281 (from geneSymbol) uc336clt.1 uc336clt.1 
ENSMUST00000329336.1 ENSMUSG00000135282 ENSMUST00000329336.1 ENSMUSG00000135282 (from geneSymbol) uc336clv.1 uc336clv.1 
ENSMUST00000329337.1 ENSMUSG00000135283 ENSMUST00000329337.1 ENSMUSG00000135283 (from geneSymbol) uc336clw.1 uc336clw.1 
ENSMUST00000329339.1 ENSMUSG00000135284 ENSMUST00000329339.1 ENSMUSG00000135284 (from geneSymbol) uc336cly.1 uc336cly.1 
ENSMUST00000329352.1 ENSMUSG00000135285 ENSMUST00000329352.1 ENSMUSG00000135285 (from geneSymbol) uc336cml.1 uc336cml.1 
ENSMUST00000329353.1 1700072G22Rik ENSMUST00000329353.1 1700072G22Rik (from geneSymbol) AK006937 uc336cmm.1 uc336cmm.1 
ENSMUST00000329359.1 ENSMUSG00000135286 ENSMUST00000329359.1 ENSMUSG00000135286 (from geneSymbol) uc336cms.1 uc336cms.1 
ENSMUST00000329363.1 ENSMUSG00000135287 ENSMUST00000329363.1 ENSMUSG00000135287 (from geneSymbol) uc336cmw.1 uc336cmw.1 
ENSMUST00000329365.1 ENSMUSG00000135288 ENSMUST00000329365.1 ENSMUSG00000135288 (from geneSymbol) AK133382 uc336cmy.1 uc336cmy.1 
ENSMUST00000329366.1 ENSMUSG00000135289 ENSMUST00000329366.1 RIKEN cDNA D630010B17 gene (from RefSeq NR_045629.1) NR_045629 uc336cmz.1 uc336cmz.1 
ENSMUST00000329367.1 ENSMUSG00000135290 ENSMUST00000329367.1 ENSMUSG00000135290 (from geneSymbol) uc336cna.1 uc336cna.1 
ENSMUST00000329368.1 ENSMUSG00000135291 ENSMUST00000329368.1 ENSMUSG00000135291 (from geneSymbol) uc336cnb.1 uc336cnb.1 
ENSMUST00000329370.1 ENSMUSG00000135292 ENSMUST00000329370.1 ENSMUSG00000135292 (from geneSymbol) uc336cnd.1 uc336cnd.1 
ENSMUST00000329371.1 ENSMUSG00000135293 ENSMUST00000329371.1 ENSMUSG00000135293 (from geneSymbol) uc336cne.1 uc336cne.1 
ENSMUST00000329372.1 ENSMUSG00000135294 ENSMUST00000329372.1 ENSMUSG00000135294 (from geneSymbol) uc336cnf.1 uc336cnf.1 
ENSMUST00000329373.1 ENSMUSG00000135295 ENSMUST00000329373.1 ENSMUSG00000135295 (from geneSymbol) uc336cng.1 uc336cng.1 
ENSMUST00000329376.1 ENSMUSG00000135296 ENSMUST00000329376.1 ENSMUSG00000135296 (from geneSymbol) uc336cnj.1 uc336cnj.1 
ENSMUST00000329379.1 ENSMUSG00000135297 ENSMUST00000329379.1 ENSMUSG00000135297 (from geneSymbol) uc336cnm.1 uc336cnm.1 
ENSMUST00000329380.1 ENSMUSG00000135298 ENSMUST00000329380.1 ENSMUSG00000135298 (from geneSymbol) uc336cnn.1 uc336cnn.1 
ENSMUST00000329381.1 ENSMUSG00000135299 ENSMUST00000329381.1 ENSMUSG00000135299 (from geneSymbol) BC100464 uc336cno.1 uc336cno.1 
ENSMUST00000329384.1 ENSMUSG00000135300 ENSMUST00000329384.1 ENSMUSG00000135300 (from geneSymbol) uc336cnr.1 uc336cnr.1 
ENSMUST00000329385.1 ENSMUSG00000135301 ENSMUST00000329385.1 ENSMUSG00000135301 (from geneSymbol) uc336cns.1 uc336cns.1 
ENSMUST00000329386.1 Frmpd1os ENSMUST00000329386.1 Frmpd1os (from geneSymbol) KY467977 uc336cnt.1 uc336cnt.1 
ENSMUST00000329387.1 4930511E03Rik ENSMUST00000329387.1 4930511E03Rik (from geneSymbol) AK019674 uc336cnu.1 uc336cnu.1 
ENSMUST00000329394.1 ENSMUSG00000135302 ENSMUST00000329394.1 ENSMUSG00000135302 (from geneSymbol) uc336cob.1 uc336cob.1 
ENSMUST00000329399.1 ENSMUSG00000135304 ENSMUST00000329399.1 ENSMUSG00000135304 (from geneSymbol) uc336cof.1 uc336cof.1 
ENSMUST00000329400.1 ENSMUSG00000135305 ENSMUST00000329400.1 ENSMUSG00000135305 (from geneSymbol) uc336cog.1 uc336cog.1 
ENSMUST00000329402.1 ENSMUSG00000135306 ENSMUST00000329402.1 ENSMUSG00000135306 (from geneSymbol) uc336coi.1 uc336coi.1 
ENSMUST00000329403.1 Gm4665 ENSMUST00000329403.1 Gm4665 (from geneSymbol) AK132957 uc336coj.1 uc336coj.1 
ENSMUST00000329410.1 ENSMUSG00000135307 ENSMUST00000329410.1 ENSMUSG00000135307 (from geneSymbol) uc336coq.1 uc336coq.1 
ENSMUST00000329411.1 ENSMUSG00000135308 ENSMUST00000329411.1 ENSMUSG00000135308 (from geneSymbol) uc336cor.1 uc336cor.1 
ENSMUST00000329412.1 ENSMUSG00000135309 ENSMUST00000329412.1 ENSMUSG00000135309 (from geneSymbol) AK005652 uc336cos.1 uc336cos.1 
ENSMUST00000329413.1 ENSMUSG00000135310 ENSMUST00000329413.1 ENSMUSG00000135310 (from geneSymbol) uc336cot.1 uc336cot.1 
ENSMUST00000329418.1 ENSMUSG00000135312 ENSMUST00000329418.1 ENSMUSG00000135312 (from geneSymbol) uc336cox.1 uc336cox.1 
ENSMUST00000329424.1 ENSMUSG00000135313 ENSMUST00000329424.1 ENSMUSG00000135313 (from geneSymbol) uc336cpd.1 uc336cpd.1 
ENSMUST00000329425.1 ENSMUSG00000135314 ENSMUST00000329425.1 ENSMUSG00000135314 (from geneSymbol) uc336cpe.1 uc336cpe.1 
ENSMUST00000329431.1 ENSMUSG00000135315 ENSMUST00000329431.1 ENSMUSG00000135315 (from geneSymbol) uc336cpk.1 uc336cpk.1 
ENSMUST00000329432.1 ENSMUSG00000135316 ENSMUST00000329432.1 ENSMUSG00000135316 (from geneSymbol) uc336cpl.1 uc336cpl.1 
ENSMUST00000329433.1 ENSMUSG00000135317 ENSMUST00000329433.1 ENSMUSG00000135317 (from geneSymbol) uc336cpm.1 uc336cpm.1 
ENSMUST00000329436.1 ENSMUSG00000135318 ENSMUST00000329436.1 ENSMUSG00000135318 (from geneSymbol) uc336cpp.1 uc336cpp.1 
ENSMUST00000329437.1 Gm26640 ENSMUST00000329437.1 Gm26640 (from geneSymbol) AK041419 uc336cpq.1 uc336cpq.1 
ENSMUST00000329438.1 ENSMUSG00000135319 ENSMUST00000329438.1 ENSMUSG00000135319 (from geneSymbol) uc336cpr.1 uc336cpr.1 
ENSMUST00000329441.1 Gm30472 ENSMUST00000329441.1 Gm30472 (from geneSymbol) uc336cpu.1 uc336cpu.1 
ENSMUST00000329446.1 ENSMUSG00000135321 ENSMUST00000329446.1 ENSMUSG00000135321 (from geneSymbol) uc336cpy.1 uc336cpy.1 
ENSMUST00000329447.1 ENSMUSG00000135322 ENSMUST00000329447.1 ENSMUSG00000135322 (from geneSymbol) uc336cpz.1 uc336cpz.1 
ENSMUST00000329448.1 ENSMUSG00000135323 ENSMUST00000329448.1 ENSMUSG00000135323 (from geneSymbol) uc336cqa.1 uc336cqa.1 
ENSMUST00000329450.1 ENSMUSG00000135324 ENSMUST00000329450.1 ENSMUSG00000135324 (from geneSymbol) uc336cqc.1 uc336cqc.1 
ENSMUST00000329452.1 ENSMUSG00000135325 ENSMUST00000329452.1 ENSMUSG00000135325 (from geneSymbol) uc336cqe.1 uc336cqe.1 
ENSMUST00000329453.1 Gm15689 ENSMUST00000329453.1 Gm15689 (from geneSymbol) AK047315 uc336cqf.1 uc336cqf.1 
ENSMUST00000329457.1 ENSMUSG00000135326 ENSMUST00000329457.1 ENSMUSG00000135326 (from geneSymbol) uc336cqj.1 uc336cqj.1 
ENSMUST00000329463.1 ENSMUSG00000135327 ENSMUST00000329463.1 ENSMUSG00000135327 (from geneSymbol) uc336cqp.1 uc336cqp.1 
ENSMUST00000329495.1 Gm57143 ENSMUST00000329495.1 Gm57143 (from geneSymbol) uc336crp.1 uc336crp.1 
ENSMUST00000329502.1 4930555G07Rik ENSMUST00000329502.1 4930555G07Rik (from geneSymbol) AK016129 uc336crw.1 uc336crw.1 
ENSMUST00000329513.1 ENSMUSG00000135328 ENSMUST00000329513.1 ENSMUSG00000135328 (from geneSymbol) uc336csh.1 uc336csh.1 
ENSMUST00000329514.1 Gm15469 ENSMUST00000329514.1 Gm15469 (from geneSymbol) AK016235 uc336csi.1 uc336csi.1 
ENSMUST00000329516.1 ENSMUSG00000135329 ENSMUST00000329516.1 ENSMUSG00000135329 (from geneSymbol) uc336csk.1 uc336csk.1 
ENSMUST00000329517.1 ENSMUSG00000135330 ENSMUST00000329517.1 ENSMUSG00000135330 (from geneSymbol) uc336csl.1 uc336csl.1 
ENSMUST00000329522.1 Mannr ENSMUST00000329522.1 Mannr (from geneSymbol) AK147070 uc336csq.1 uc336csq.1 
ENSMUST00000329532.1 ENSMUSG00000135331 ENSMUST00000329532.1 ENSMUSG00000135331 (from geneSymbol) uc336cta.1 uc336cta.1 
ENSMUST00000329534.1 ENSMUSG00000135332 ENSMUST00000329534.1 ENSMUSG00000135332 (from geneSymbol) uc336ctc.1 uc336ctc.1 
ENSMUST00000329535.1 ENSMUSG00000135333 ENSMUST00000329535.1 ENSMUSG00000135333 (from geneSymbol) uc336ctd.1 uc336ctd.1 
ENSMUST00000329536.1 ENSMUSG00000135334 ENSMUST00000329536.1 ENSMUSG00000135334 (from geneSymbol) uc336cte.1 uc336cte.1 
ENSMUST00000329537.1 ENSMUSG00000135335 ENSMUST00000329537.1 ENSMUSG00000135335 (from geneSymbol) uc336ctf.1 uc336ctf.1 
ENSMUST00000329540.1 ENSMUSG00000135336 ENSMUST00000329540.1 ENSMUSG00000135336 (from geneSymbol) uc336cti.1 uc336cti.1 
ENSMUST00000329561.1 ENSMUSG00000135337 ENSMUST00000329561.1 ENSMUSG00000135337 (from geneSymbol) uc336cud.1 uc336cud.1 
ENSMUST00000329563.1 ENSMUSG00000135338 ENSMUST00000329563.1 ENSMUSG00000135338 (from geneSymbol) uc336cuf.1 uc336cuf.1 
ENSMUST00000329564.1 ENSMUSG00000135339 ENSMUST00000329564.1 ENSMUSG00000135339 (from geneSymbol) uc336cug.1 uc336cug.1 
ENSMUST00000329566.1 ENSMUSG00000135340 ENSMUST00000329566.1 ENSMUSG00000135340 (from geneSymbol) uc336cui.1 uc336cui.1 
ENSMUST00000329568.1 ENSMUSG00000135341 ENSMUST00000329568.1 ENSMUSG00000135341 (from geneSymbol) uc336cuk.1 uc336cuk.1 
ENSMUST00000329571.1 ENSMUSG00000135342 ENSMUST00000329571.1 ENSMUSG00000135342 (from geneSymbol) uc336cun.1 uc336cun.1 
ENSMUST00000329572.1 ENSMUSG00000135343 ENSMUST00000329572.1 ENSMUSG00000135343 (from geneSymbol) uc336cuo.1 uc336cuo.1 
ENSMUST00000329573.1 ENSMUSG00000135344 ENSMUST00000329573.1 ENSMUSG00000135344 (from geneSymbol) uc336cup.1 uc336cup.1 
ENSMUST00000329574.1 ENSMUSG00000135345 ENSMUST00000329574.1 ENSMUSG00000135345 (from geneSymbol) uc336cuq.1 uc336cuq.1 
ENSMUST00000329576.1 ENSMUSG00000135346 ENSMUST00000329576.1 ENSMUSG00000135346 (from geneSymbol) uc336cus.1 uc336cus.1 
ENSMUST00000329577.1 ENSMUSG00000135347 ENSMUST00000329577.1 ENSMUSG00000135347 (from geneSymbol) uc336cut.1 uc336cut.1 
ENSMUST00000329578.1 ENSMUSG00000135348 ENSMUST00000329578.1 ENSMUSG00000135348 (from geneSymbol) uc336cuu.1 uc336cuu.1 
ENSMUST00000329580.1 ENSMUSG00000135349 ENSMUST00000329580.1 ENSMUSG00000135349 (from geneSymbol) uc336cuw.1 uc336cuw.1 
ENSMUST00000329583.1 ENSMUSG00000135350 ENSMUST00000329583.1 ENSMUSG00000135350 (from geneSymbol) uc336cuz.1 uc336cuz.1 
ENSMUST00000329586.1 ENSMUSG00000135351 ENSMUST00000329586.1 ENSMUSG00000135351 (from geneSymbol) uc336cvc.1 uc336cvc.1 
ENSMUST00000329587.1 ENSMUSG00000135352 ENSMUST00000329587.1 ENSMUSG00000135352 (from geneSymbol) uc336cvd.1 uc336cvd.1 
ENSMUST00000329588.1 ENSMUSG00000135353 ENSMUST00000329588.1 ENSMUSG00000135353 (from geneSymbol) uc336cve.1 uc336cve.1 
ENSMUST00000329589.1 ENSMUSG00000135354 ENSMUST00000329589.1 ENSMUSG00000135354 (from geneSymbol) uc336cvf.1 uc336cvf.1 
ENSMUST00000329593.1 ENSMUSG00000135355 ENSMUST00000329593.1 ENSMUSG00000135355 (from geneSymbol) uc336cvj.1 uc336cvj.1 
ENSMUST00000329595.1 ENSMUSG00000135356 ENSMUST00000329595.1 ENSMUSG00000135356 (from geneSymbol) uc336cvl.1 uc336cvl.1 
ENSMUST00000329597.1 Gm33125 ENSMUST00000329597.1 Gm33125 (from geneSymbol) uc336cvn.1 uc336cvn.1 
ENSMUST00000329624.1 ENSMUSG00000135357 ENSMUST00000329624.1 ENSMUSG00000135357 (from geneSymbol) uc336cwo.1 uc336cwo.1 
ENSMUST00000329626.1 ENSMUSG00000135358 ENSMUST00000329626.1 ENSMUSG00000135358 (from geneSymbol) uc336cwq.1 uc336cwq.1 
ENSMUST00000329627.1 ENSMUSG00000135359 ENSMUST00000329627.1 ENSMUSG00000135359 (from geneSymbol) uc336cwr.1 uc336cwr.1 
ENSMUST00000329630.1 ENSMUSG00000135360 ENSMUST00000329630.1 ENSMUSG00000135360 (from geneSymbol) uc336cwu.1 uc336cwu.1 
ENSMUST00000329631.1 ENSMUSG00000135361 ENSMUST00000329631.1 ENSMUSG00000135361 (from geneSymbol) uc336cwv.1 uc336cwv.1 
ENSMUST00000329632.1 ENSMUSG00000135362 ENSMUST00000329632.1 ENSMUSG00000135362 (from geneSymbol) uc336cww.1 uc336cww.1 
ENSMUST00000329633.1 ENSMUSG00000135363 ENSMUST00000329633.1 ENSMUSG00000135363 (from geneSymbol) uc336cwx.1 uc336cwx.1 
ENSMUST00000329637.1 4930479H17Rik ENSMUST00000329637.1 4930479H17Rik (from geneSymbol) AK019648 uc336cxb.1 uc336cxb.1 
ENSMUST00000329638.1 1810064F22Rik ENSMUST00000329638.1 1810064F22Rik (from geneSymbol) AK007952 uc336cxc.1 uc336cxc.1 
ENSMUST00000329642.1 ENSMUSG00000135364 ENSMUST00000329642.1 ENSMUSG00000135364 (from geneSymbol) uc336cxg.1 uc336cxg.1 
ENSMUST00000329643.1 ENSMUSG00000135365 ENSMUST00000329643.1 ENSMUSG00000135365 (from geneSymbol) uc336cxh.1 uc336cxh.1 
ENSMUST00000329648.1 ENSMUSG00000135366 ENSMUST00000329648.1 ENSMUSG00000135366 (from geneSymbol) uc336cxm.1 uc336cxm.1 
ENSMUST00000329649.1 ENSMUSG00000135367 ENSMUST00000329649.1 ENSMUSG00000135367 (from geneSymbol) uc336cxn.1 uc336cxn.1 
ENSMUST00000329651.1 ENSMUSG00000135368 ENSMUST00000329651.1 ENSMUSG00000135368 (from geneSymbol) uc336cxp.1 uc336cxp.1 
ENSMUST00000329653.1 ENSMUSG00000135369 ENSMUST00000329653.1 ENSMUSG00000135369 (from geneSymbol) uc336cxr.1 uc336cxr.1 
ENSMUST00000329660.1 ENSMUSG00000135370 ENSMUST00000329660.1 ENSMUSG00000135370 (from geneSymbol) uc336cxy.1 uc336cxy.1 
ENSMUST00000329661.1 ENSMUSG00000135371 ENSMUST00000329661.1 ENSMUSG00000135371 (from geneSymbol) uc336cxz.1 uc336cxz.1 
ENSMUST00000329663.1 ENSMUSG00000135372 ENSMUST00000329663.1 ENSMUSG00000135372 (from geneSymbol) uc336cyb.1 uc336cyb.1 
ENSMUST00000329664.1 Gm16271 ENSMUST00000329664.1 predicted gene 16271 (from RefSeq NR_165263.1) NR_165263 uc336cyc.1 uc336cyc.1 
ENSMUST00000329667.1 ENSMUSG00000135373 ENSMUST00000329667.1 ENSMUSG00000135373 (from geneSymbol) uc336cyf.1 uc336cyf.1 
ENSMUST00000329675.1 ENSMUSG00000135374 ENSMUST00000329675.1 ENSMUSG00000135374 (from geneSymbol) uc336cyn.1 uc336cyn.1 
ENSMUST00000329678.1 ENSMUSG00000135375 ENSMUST00000329678.1 ENSMUSG00000135375 (from geneSymbol) uc336cyq.1 uc336cyq.1 
ENSMUST00000329683.1 ENSMUSG00000135376 ENSMUST00000329683.1 ENSMUSG00000135376 (from geneSymbol) uc336cyv.1 uc336cyv.1 
ENSMUST00000329684.1 Smc2os ENSMUST00000329684.1 Smc2os (from geneSymbol) AK012547 uc336cyw.1 uc336cyw.1 
ENSMUST00000329693.1 ENSMUSG00000135377 ENSMUST00000329693.1 ENSMUSG00000135377 (from geneSymbol) uc336czf.1 uc336czf.1 
ENSMUST00000329694.1 ENSMUSG00000135378 ENSMUST00000329694.1 ENSMUSG00000135378 (from geneSymbol) uc336czg.1 uc336czg.1 
ENSMUST00000329698.1 ENSMUSG00000135379 ENSMUST00000329698.1 ENSMUSG00000135379 (from geneSymbol) uc336czk.1 uc336czk.1 
ENSMUST00000329699.1 ENSMUSG00000135380 ENSMUST00000329699.1 ENSMUSG00000135380 (from geneSymbol) uc336czl.1 uc336czl.1 
ENSMUST00000329700.1 ENSMUSG00000135381 ENSMUST00000329700.1 ENSMUSG00000135381 (from geneSymbol) uc336czm.1 uc336czm.1 
ENSMUST00000329707.1 ENSMUSG00000135382 ENSMUST00000329707.1 ENSMUSG00000135382 (from geneSymbol) uc336czt.1 uc336czt.1 
ENSMUST00000329708.1 ENSMUSG00000135383 ENSMUST00000329708.1 ENSMUSG00000135383 (from geneSymbol) uc336czu.1 uc336czu.1 
ENSMUST00000329712.1 Gm2682 ENSMUST00000329712.1 Gm2682 (from geneSymbol) AK041614 uc336czy.1 uc336czy.1 
ENSMUST00000329745.1 ENSMUSG00000135384 ENSMUST00000329745.1 ENSMUSG00000135384 (from geneSymbol) uc336dbf.1 uc336dbf.1 
ENSMUST00000329746.1 ENSMUSG00000135385 ENSMUST00000329746.1 ENSMUSG00000135385 (from geneSymbol) uc336dbg.1 uc336dbg.1 
ENSMUST00000329747.1 ENSMUSG00000135386 ENSMUST00000329747.1 ENSMUSG00000135386 (from geneSymbol) uc336dbh.1 uc336dbh.1 
ENSMUST00000329752.1 ENSMUSG00000135387 ENSMUST00000329752.1 ENSMUSG00000135387 (from geneSymbol) uc336dbl.1 uc336dbl.1 
ENSMUST00000329753.1 ENSMUSG00000135388 ENSMUST00000329753.1 ENSMUSG00000135388 (from geneSymbol) uc336dbm.1 uc336dbm.1 
ENSMUST00000329762.1 ENSMUSG00000135389 ENSMUST00000329762.1 ENSMUSG00000135389 (from geneSymbol) uc336dbv.1 uc336dbv.1 
ENSMUST00000329766.1 ENSMUSG00000135390 ENSMUST00000329766.1 ENSMUSG00000135390 (from geneSymbol) uc336dbz.1 uc336dbz.1 
ENSMUST00000329770.1 ENSMUSG00000135391 ENSMUST00000329770.1 ENSMUSG00000135391 (from geneSymbol) uc336dcd.1 uc336dcd.1 
ENSMUST00000329777.1 ENSMUSG00000135392 ENSMUST00000329777.1 ENSMUSG00000135392 (from geneSymbol) uc336dck.1 uc336dck.1 
ENSMUST00000329780.1 ENSMUSG00000135393 ENSMUST00000329780.1 ENSMUSG00000135393 (from geneSymbol) uc336dcn.1 uc336dcn.1 
ENSMUST00000329788.1 ENSMUSG00000135394 ENSMUST00000329788.1 ENSMUSG00000135394 (from geneSymbol) uc336dcv.1 uc336dcv.1 
ENSMUST00000329790.1 ENSMUSG00000135395 ENSMUST00000329790.1 ENSMUSG00000135395 (from geneSymbol) BC049690 uc336dcx.1 uc336dcx.1 
ENSMUST00000329794.1 ENSMUSG00000135397 ENSMUST00000329794.1 ENSMUSG00000135397 (from geneSymbol) BC069935 uc336dcz.1 uc336dcz.1 
ENSMUST00000329795.1 ENSMUSG00000135398 ENSMUST00000329795.1 ENSMUSG00000135398 (from geneSymbol) uc336dda.1 uc336dda.1 
ENSMUST00000329804.1 ENSMUSG00000135399 ENSMUST00000329804.1 ENSMUSG00000135399 (from geneSymbol) uc336ddj.1 uc336ddj.1 
ENSMUST00000329805.1 ENSMUSG00000135400 ENSMUST00000329805.1 ENSMUSG00000135400 (from geneSymbol) uc336ddk.1 uc336ddk.1 
ENSMUST00000329807.1 ENSMUSG00000135401 ENSMUST00000329807.1 ENSMUSG00000135401 (from geneSymbol) uc336ddm.1 uc336ddm.1 
ENSMUST00000329808.1 ENSMUSG00000135402 ENSMUST00000329808.1 ENSMUSG00000135402 (from geneSymbol) uc336ddn.1 uc336ddn.1 
ENSMUST00000329810.1 ENSMUSG00000135404 ENSMUST00000329810.1 ENSMUSG00000135404 (from geneSymbol) uc336ddo.1 uc336ddo.1 
ENSMUST00000329811.1 ENSMUSG00000135405 ENSMUST00000329811.1 ENSMUSG00000135405 (from geneSymbol) uc336ddp.1 uc336ddp.1 
ENSMUST00000329812.1 ENSMUSG00000135406 ENSMUST00000329812.1 ENSMUSG00000135406 (from geneSymbol) uc336ddq.1 uc336ddq.1 
ENSMUST00000329813.1 ENSMUSG00000135407 ENSMUST00000329813.1 ENSMUSG00000135407 (from geneSymbol) uc336ddr.1 uc336ddr.1 
ENSMUST00000329831.1 Gm14221 ENSMUST00000329831.1 Gm14221 (from geneSymbol) uc336dej.1 uc336dej.1 
ENSMUST00000329868.1 ENSMUSG00000135408 ENSMUST00000329868.1 ENSMUSG00000135408 (from geneSymbol) uc336dfu.1 uc336dfu.1 
ENSMUST00000329873.1 ENSMUSG00000135409 ENSMUST00000329873.1 ENSMUSG00000135409 (from geneSymbol) uc336dfz.1 uc336dfz.1 
ENSMUST00000329881.1 ENSMUSG00000121800 ENSMUST00000329881.1 ENSMUSG00000121800 (from geneSymbol) AK132937 uc336dgh.1 uc336dgh.1 
ENSMUST00000329886.1 Gm35028 ENSMUST00000329886.1 Gm35028 (from geneSymbol) uc336dgm.1 uc336dgm.1 
ENSMUST00000329916.1 ENSMUSG00000135410 ENSMUST00000329916.1 ENSMUSG00000135410 (from geneSymbol) uc336dhq.1 uc336dhq.1 
ENSMUST00000329920.1 ENSMUSG00000135411 ENSMUST00000329920.1 ENSMUSG00000135411 (from geneSymbol) uc336dhu.1 uc336dhu.1 
ENSMUST00000329921.1 Gm3942 ENSMUST00000329921.1 Gm3942 (from geneSymbol) AK036450 uc336dhv.1 uc336dhv.1 
ENSMUST00000329928.1 ENSMUSG00000135412 ENSMUST00000329928.1 ENSMUSG00000135412 (from geneSymbol) uc336dic.1 uc336dic.1 
ENSMUST00000329929.1 ENSMUSG00000135413 ENSMUST00000329929.1 ENSMUSG00000135413 (from geneSymbol) uc336did.1 uc336did.1 
ENSMUST00000329930.1 ENSMUSG00000135414 ENSMUST00000329930.1 ENSMUSG00000135414 (from geneSymbol) uc336die.1 uc336die.1 
ENSMUST00000329931.1 ENSMUSG00000135415 ENSMUST00000329931.1 ENSMUSG00000135415 (from geneSymbol) uc336dif.1 uc336dif.1 
ENSMUST00000329932.1 ENSMUSG00000135416 ENSMUST00000329932.1 ENSMUSG00000135416 (from geneSymbol) uc336dig.1 uc336dig.1 
ENSMUST00000329933.1 ENSMUSG00000135417 ENSMUST00000329933.1 ENSMUSG00000135417 (from geneSymbol) uc336dih.1 uc336dih.1 
ENSMUST00000329941.1 ENSMUSG00000135418 ENSMUST00000329941.1 ENSMUSG00000135418 (from geneSymbol) uc336dip.1 uc336dip.1 
ENSMUST00000329942.1 ENSMUSG00000135419 ENSMUST00000329942.1 ENSMUSG00000135419 (from geneSymbol) uc336diq.1 uc336diq.1 
ENSMUST00000329955.1 ENSMUSG00000135420 ENSMUST00000329955.1 ENSMUSG00000135420 (from geneSymbol) uc336djd.1 uc336djd.1 
ENSMUST00000329956.1 1700047L14Rik ENSMUST00000329956.1 1700047L14Rik (from geneSymbol) AK006716 uc336dje.1 uc336dje.1 
ENSMUST00000329964.1 ENSMUSG00000135421 ENSMUST00000329964.1 ENSMUSG00000135421 (from geneSymbol) uc336djm.1 uc336djm.1 
ENSMUST00000329967.1 ENSMUSG00000135422 ENSMUST00000329967.1 ENSMUSG00000135422 (from geneSymbol) uc336djp.1 uc336djp.1 
ENSMUST00000329971.1 ENSMUSG00000135423 ENSMUST00000329971.1 ENSMUSG00000135423 (from geneSymbol) uc336djt.1 uc336djt.1 
ENSMUST00000329978.1 BB218582 ENSMUST00000329978.1 BB218582 (from geneSymbol) KY467885 uc336dka.1 uc336dka.1 
ENSMUST00000330042.1 ENSMUSG00000135424 ENSMUST00000330042.1 ENSMUSG00000135424 (from geneSymbol) uc336dmm.1 uc336dmm.1 
ENSMUST00000330043.1 ENSMUSG00000135425 ENSMUST00000330043.1 ENSMUSG00000135425 (from geneSymbol) uc336dmn.1 uc336dmn.1 
ENSMUST00000330047.1 ENSMUSG00000135426 ENSMUST00000330047.1 ENSMUSG00000135426 (from geneSymbol) uc336dmr.1 uc336dmr.1 
ENSMUST00000330055.1 ENSMUSG00000135427 ENSMUST00000330055.1 ENSMUSG00000135427 (from geneSymbol) uc336dmz.1 uc336dmz.1 
ENSMUST00000330056.1 Gm41331 ENSMUST00000330056.1 Gm41331 (from geneSymbol) uc336dna.1 uc336dna.1 
ENSMUST00000330087.1 ENSMUSG00000135428 ENSMUST00000330087.1 ENSMUSG00000135428 (from geneSymbol) uc336dof.1 uc336dof.1 
ENSMUST00000330088.1 Gm47499 ENSMUST00000330088.1 Gm47499 (from geneSymbol) uc336dog.1 uc336dog.1 
ENSMUST00000330090.1 ENSMUSG00000135429 ENSMUST00000330090.1 ENSMUSG00000135429 (from geneSymbol) uc336doi.1 uc336doi.1 
ENSMUST00000330091.1 ENSMUSG00000135430 ENSMUST00000330091.1 ENSMUSG00000135430 (from geneSymbol) uc336doj.1 uc336doj.1 
ENSMUST00000330092.1 ENSMUSG00000135431 ENSMUST00000330092.1 ENSMUSG00000135431 (from geneSymbol) uc336dok.1 uc336dok.1 
ENSMUST00000330093.1 ENSMUSG00000135432 ENSMUST00000330093.1 ENSMUSG00000135432 (from geneSymbol) uc336dol.1 uc336dol.1 
ENSMUST00000330094.1 Gm34158 ENSMUST00000330094.1 Gm34158 (from geneSymbol) uc336dom.1 uc336dom.1 
ENSMUST00000330097.1 ENSMUSG00000135433 ENSMUST00000330097.1 ENSMUSG00000135433 (from geneSymbol) uc336dop.1 uc336dop.1 
ENSMUST00000330098.1 ENSMUSG00000135434 ENSMUST00000330098.1 ENSMUSG00000135434 (from geneSymbol) uc336doq.1 uc336doq.1 
ENSMUST00000330101.1 1700109I08Rik ENSMUST00000330101.1 1700109I08Rik (from geneSymbol) AK007151 uc336dot.1 uc336dot.1 
ENSMUST00000330112.1 ENSMUSG00000135435 ENSMUST00000330112.1 ENSMUSG00000135435 (from geneSymbol) uc336dpe.1 uc336dpe.1 
ENSMUST00000330114.1 ENSMUSG00000135436 ENSMUST00000330114.1 ENSMUSG00000135436 (from geneSymbol) uc336dpg.1 uc336dpg.1 
ENSMUST00000330115.1 ENSMUSG00000135437 ENSMUST00000330115.1 ENSMUSG00000135437 (from geneSymbol) uc336dph.1 uc336dph.1 
ENSMUST00000330118.1 ENSMUSG00000135438 ENSMUST00000330118.1 ENSMUSG00000135438 (from geneSymbol) uc336dpk.1 uc336dpk.1 
ENSMUST00000330122.1 ENSMUSG00000135439 ENSMUST00000330122.1 ENSMUSG00000135439 (from geneSymbol) uc336dpo.1 uc336dpo.1 
ENSMUST00000330123.1 ENSMUSG00000135440 ENSMUST00000330123.1 ENSMUSG00000135440 (from geneSymbol) uc336dpp.1 uc336dpp.1 
ENSMUST00000330124.1 ENSMUSG00000135441 ENSMUST00000330124.1 ENSMUSG00000135441 (from geneSymbol) uc336dpq.1 uc336dpq.1 
ENSMUST00000330128.1 ENSMUSG00000135442 ENSMUST00000330128.1 ENSMUSG00000135442 (from geneSymbol) uc336dpu.1 uc336dpu.1 
ENSMUST00000330130.1 ENSMUSG00000135443 ENSMUST00000330130.1 ENSMUSG00000135443 (from geneSymbol) uc336dpw.1 uc336dpw.1 
ENSMUST00000330132.1 1700009C05Rik ENSMUST00000330132.1 1700009C05Rik (from geneSymbol) AK005792 uc336dpy.1 uc336dpy.1 
ENSMUST00000330158.1 ENSMUSG00000135444 ENSMUST00000330158.1 ENSMUSG00000135444 (from geneSymbol) uc336dqy.1 uc336dqy.1 
ENSMUST00000330159.1 ENSMUSG00000135445 ENSMUST00000330159.1 ENSMUSG00000135445 (from geneSymbol) uc336dqz.1 uc336dqz.1 
ENSMUST00000330174.1 ENSMUSG00000135446 ENSMUST00000330174.1 ENSMUSG00000135446 (from geneSymbol) uc336dro.1 uc336dro.1 
ENSMUST00000330175.1 ENSMUSG00000135447 ENSMUST00000330175.1 ENSMUSG00000135447 (from geneSymbol) uc336drp.1 uc336drp.1 
ENSMUST00000330176.1 ENSMUSG00000135448 ENSMUST00000330176.1 ENSMUSG00000135448 (from geneSymbol) uc336drq.1 uc336drq.1 
ENSMUST00000330177.1 ENSMUSG00000135449 ENSMUST00000330177.1 ENSMUSG00000135449 (from geneSymbol) uc336drr.1 uc336drr.1 
ENSMUST00000330178.1 ENSMUSG00000135450 ENSMUST00000330178.1 ENSMUSG00000135450 (from geneSymbol) uc336drs.1 uc336drs.1 
ENSMUST00000330182.1 ENSMUSG00000135451 ENSMUST00000330182.1 ENSMUSG00000135451 (from geneSymbol) uc336drw.1 uc336drw.1 
ENSMUST00000330184.1 ENSMUSG00000135452 ENSMUST00000330184.1 ENSMUSG00000135452 (from geneSymbol) uc336dry.1 uc336dry.1 
ENSMUST00000330187.1 ENSMUSG00000135453 ENSMUST00000330187.1 ENSMUSG00000135453 (from geneSymbol) uc336dsb.1 uc336dsb.1 
ENSMUST00000330203.1 ENSMUSG00000135454 ENSMUST00000330203.1 ENSMUSG00000135454 (from geneSymbol) uc336dsr.1 uc336dsr.1 
ENSMUST00000330205.1 ENSMUSG00000135455 ENSMUST00000330205.1 ENSMUSG00000135455 (from geneSymbol) uc336dst.1 uc336dst.1 
ENSMUST00000330259.1 ENSMUSG00000135456 ENSMUST00000330259.1 ENSMUSG00000135456 (from geneSymbol) uc336duv.1 uc336duv.1 
ENSMUST00000330260.1 ENSMUSG00000135457 ENSMUST00000330260.1 ENSMUSG00000135457 (from geneSymbol) uc336duw.1 uc336duw.1 
ENSMUST00000330281.1 ENSMUSG00000135458 ENSMUST00000330281.1 ENSMUSG00000135458 (from geneSymbol) uc336dvr.1 uc336dvr.1 
ENSMUST00000330296.1 ENSMUSG00000135459 ENSMUST00000330296.1 ENSMUSG00000135459 (from geneSymbol) uc336dwg.1 uc336dwg.1 
ENSMUST00000330298.1 ENSMUSG00000135460 ENSMUST00000330298.1 ENSMUSG00000135460 (from geneSymbol) LF196609 uc336dwi.1 uc336dwi.1 
ENSMUST00000330301.1 ENSMUSG00000135461 ENSMUST00000330301.1 ENSMUSG00000135461 (from geneSymbol) uc336dwl.1 uc336dwl.1 
ENSMUST00000330310.1 ENSMUSG00000135463 ENSMUST00000330310.1 ENSMUSG00000135463 (from geneSymbol) uc336dws.1 uc336dws.1 
ENSMUST00000330311.1 ENSMUSG00000135464 ENSMUST00000330311.1 ENSMUSG00000135464 (from geneSymbol) uc336dwt.1 uc336dwt.1 
ENSMUST00000330312.1 ENSMUSG00000135465 ENSMUST00000330312.1 ENSMUSG00000135465 (from geneSymbol) uc336dwu.1 uc336dwu.1 
ENSMUST00000330314.1 ENSMUSG00000135466 ENSMUST00000330314.1 ENSMUSG00000135466 (from geneSymbol) uc336dww.1 uc336dww.1 
ENSMUST00000330315.1 ENSMUSG00000135467 ENSMUST00000330315.1 ENSMUSG00000135467 (from geneSymbol) uc336dwx.1 uc336dwx.1 
ENSMUST00000330321.1 ENSMUSG00000135468 ENSMUST00000330321.1 ENSMUSG00000135468 (from geneSymbol) uc336dxd.1 uc336dxd.1 
ENSMUST00000330322.1 ENSMUSG00000135469 ENSMUST00000330322.1 ENSMUSG00000135469 (from geneSymbol) uc336dxe.1 uc336dxe.1 
ENSMUST00000330323.1 3300005D01Rik ENSMUST00000330323.1 3300005D01Rik (from geneSymbol) KY467771 uc336dxf.1 uc336dxf.1 
ENSMUST00000330331.1 ENSMUSG00000135470 ENSMUST00000330331.1 ENSMUSG00000135470 (from geneSymbol) uc336dxn.1 uc336dxn.1 
ENSMUST00000330332.1 ENSMUSG00000135471 ENSMUST00000330332.1 ENSMUSG00000135471 (from geneSymbol) uc336dxo.1 uc336dxo.1 
ENSMUST00000330333.1 ENSMUSG00000135472 ENSMUST00000330333.1 ENSMUSG00000135472 (from geneSymbol) uc336dxp.1 uc336dxp.1 
ENSMUST00000330335.1 ENSMUSG00000135473 ENSMUST00000330335.1 ENSMUSG00000135473 (from geneSymbol) uc336dxr.1 uc336dxr.1 
ENSMUST00000330336.1 ENSMUSG00000135474 ENSMUST00000330336.1 ENSMUSG00000135474 (from geneSymbol) uc336dxs.1 uc336dxs.1 
ENSMUST00000330337.1 ENSMUSG00000135475 ENSMUST00000330337.1 ENSMUSG00000135475 (from geneSymbol) uc336dxt.1 uc336dxt.1 
ENSMUST00000330338.1 ENSMUSG00000135476 ENSMUST00000330338.1 ENSMUSG00000135476 (from geneSymbol) uc336dxu.1 uc336dxu.1 
ENSMUST00000330346.1 Cfhr3 ENSMUST00000330346.1 Cfhr3 (from geneSymbol) AK015277 uc336dyc.1 uc336dyc.1 
ENSMUST00000330371.1 ENSMUSG00000135478 ENSMUST00000330371.1 ENSMUSG00000135478 (from geneSymbol) uc336dzb.1 uc336dzb.1 
ENSMUST00000330372.1 ENSMUSG00000135479 ENSMUST00000330372.1 ENSMUSG00000135479 (from geneSymbol) uc336dzc.1 uc336dzc.1 
ENSMUST00000330373.1 ENSMUSG00000135480 ENSMUST00000330373.1 ENSMUSG00000135480 (from geneSymbol) uc336dzd.1 uc336dzd.1 
ENSMUST00000330376.1 ENSMUSG00000135481 ENSMUST00000330376.1 ENSMUSG00000135481 (from geneSymbol) uc336dzg.1 uc336dzg.1 
ENSMUST00000330377.1 ENSMUSG00000135482 ENSMUST00000330377.1 ENSMUSG00000135482 (from geneSymbol) uc336dzh.1 uc336dzh.1 
ENSMUST00000330380.1 Gm36667 ENSMUST00000330380.1 Gm36667 (from geneSymbol) AK076755 uc336dzk.1 uc336dzk.1 
ENSMUST00000330388.1 ENSMUSG00000135483 ENSMUST00000330388.1 ENSMUSG00000135483 (from geneSymbol) uc336dzs.1 uc336dzs.1 
ENSMUST00000330400.1 ENSMUSG00000135484 ENSMUST00000330400.1 ENSMUSG00000135484 (from geneSymbol) uc336eae.1 uc336eae.1 
ENSMUST00000330401.1 ENSMUSG00000135485 ENSMUST00000330401.1 ENSMUSG00000135485 (from geneSymbol) uc336eaf.1 uc336eaf.1 
ENSMUST00000330402.1 ENSMUSG00000135486 ENSMUST00000330402.1 ENSMUSG00000135486 (from geneSymbol) uc336eag.1 uc336eag.1 
ENSMUST00000330407.1 ENSMUSG00000135487 ENSMUST00000330407.1 ENSMUSG00000135487 (from geneSymbol) uc336eal.1 uc336eal.1 
ENSMUST00000330408.1 ENSMUSG00000135488 ENSMUST00000330408.1 ENSMUSG00000135488 (from geneSymbol) uc336eam.1 uc336eam.1 
ENSMUST00000330411.1 ENSMUSG00000135489 ENSMUST00000330411.1 ENSMUSG00000135489 (from geneSymbol) uc336eap.1 uc336eap.1 
ENSMUST00000330425.1 ENSMUSG00000135490 ENSMUST00000330425.1 ENSMUSG00000135490 (from geneSymbol) uc336ebd.1 uc336ebd.1 
ENSMUST00000330459.1 ENSMUSG00000135491 ENSMUST00000330459.1 ENSMUSG00000135491 (from geneSymbol) uc336ecl.1 uc336ecl.1 
ENSMUST00000330461.1 ENSMUSG00000135492 ENSMUST00000330461.1 ENSMUSG00000135492 (from geneSymbol) uc336ecn.1 uc336ecn.1 
ENSMUST00000330462.1 ENSMUSG00000135493 ENSMUST00000330462.1 ENSMUSG00000135493 (from geneSymbol) uc336eco.1 uc336eco.1 
ENSMUST00000330467.1 ENSMUSG00000135495 ENSMUST00000330467.1 ENSMUSG00000135495 (from geneSymbol) uc336ecs.1 uc336ecs.1 
ENSMUST00000330468.1 ENSMUSG00000135496 ENSMUST00000330468.1 ENSMUSG00000135496 (from geneSymbol) uc336ect.1 uc336ect.1 
ENSMUST00000330477.1 ENSMUSG00000135497 ENSMUST00000330477.1 ENSMUSG00000135497 (from geneSymbol) uc336edc.1 uc336edc.1 
ENSMUST00000330478.1 ENSMUSG00000135498 ENSMUST00000330478.1 ENSMUSG00000135498 (from geneSymbol) uc336edd.1 uc336edd.1 
ENSMUST00000330479.1 ENSMUSG00000135499 ENSMUST00000330479.1 ENSMUSG00000135499 (from geneSymbol) uc336ede.1 uc336ede.1 
ENSMUST00000330484.1 ENSMUSG00000135500 ENSMUST00000330484.1 ENSMUSG00000135500 (from geneSymbol) uc336edj.1 uc336edj.1 
ENSMUST00000330492.1 ENSMUSG00000135501 ENSMUST00000330492.1 ENSMUSG00000135501 (from geneSymbol) uc336edr.1 uc336edr.1 
ENSMUST00000330496.1 ENSMUSG00000135502 ENSMUST00000330496.1 ENSMUSG00000135502 (from geneSymbol) uc336edv.1 uc336edv.1 
ENSMUST00000330499.1 Gm13791 ENSMUST00000330499.1 Gm13791 (from geneSymbol) uc336edy.1 uc336edy.1 
ENSMUST00000330527.1 Gm17210 ENSMUST00000330527.1 Gm17210 (from geneSymbol) AK133572 uc336eez.1 uc336eez.1 
ENSMUST00000330537.1 ENSMUSG00000135504 ENSMUST00000330537.1 ENSMUSG00000135504 (from geneSymbol) uc336efj.1 uc336efj.1 
ENSMUST00000330563.1 ENSMUSG00000135505 ENSMUST00000330563.1 ENSMUSG00000135505 (from geneSymbol) uc336egj.1 uc336egj.1 
ENSMUST00000330564.1 ENSMUSG00000135506 ENSMUST00000330564.1 ENSMUSG00000135506 (from geneSymbol) uc336egk.1 uc336egk.1 
ENSMUST00000330565.1 ENSMUSG00000135507 ENSMUST00000330565.1 ENSMUSG00000135507 (from geneSymbol) uc336egl.1 uc336egl.1 
ENSMUST00000330566.1 ENSMUSG00000135508 ENSMUST00000330566.1 ENSMUSG00000135508 (from geneSymbol) uc336egm.1 uc336egm.1 
ENSMUST00000330568.1 ENSMUSG00000135509 ENSMUST00000330568.1 ENSMUSG00000135509 (from geneSymbol) uc336ego.1 uc336ego.1 
ENSMUST00000330569.1 ENSMUSG00000135510 ENSMUST00000330569.1 ENSMUSG00000135510 (from geneSymbol) uc336egp.1 uc336egp.1 
ENSMUST00000330570.1 ENSMUSG00000135511 ENSMUST00000330570.1 ENSMUSG00000135511 (from geneSymbol) uc336egq.1 uc336egq.1 
ENSMUST00000330571.1 ENSMUSG00000135512 ENSMUST00000330571.1 ENSMUSG00000135512 (from geneSymbol) uc336egr.1 uc336egr.1 
ENSMUST00000330573.1 ENSMUSG00000135513 ENSMUST00000330573.1 ENSMUSG00000135513 (from geneSymbol) uc336egt.1 uc336egt.1 
ENSMUST00000330574.1 ENSMUSG00000135514 ENSMUST00000330574.1 ENSMUSG00000135514 (from geneSymbol) uc336egu.1 uc336egu.1 
ENSMUST00000330590.1 ENSMUSG00000135515 ENSMUST00000330590.1 ENSMUSG00000135515 (from geneSymbol) uc336ehk.1 uc336ehk.1 
ENSMUST00000330606.1 ENSMUSG00000135516 ENSMUST00000330606.1 ENSMUSG00000135516 (from geneSymbol) uc336eia.1 uc336eia.1 
ENSMUST00000330608.1 ENSMUSG00000135518 ENSMUST00000330608.1 ENSMUSG00000135518 (from geneSymbol) uc336eib.1 uc336eib.1 
ENSMUST00000330609.1 ENSMUSG00000135519 ENSMUST00000330609.1 ENSMUSG00000135519 (from geneSymbol) LF194082 uc336eic.1 uc336eic.1 
ENSMUST00000330610.1 ENSMUSG00000135520 ENSMUST00000330610.1 ENSMUSG00000135520 (from geneSymbol) uc336eid.1 uc336eid.1 
ENSMUST00000330618.1 ENSMUSG00000135521 ENSMUST00000330618.1 ENSMUSG00000135521 (from geneSymbol) uc336eil.1 uc336eil.1 
ENSMUST00000330620.1 ENSMUSG00000135522 ENSMUST00000330620.1 ENSMUSG00000135522 (from geneSymbol) uc336ein.1 uc336ein.1 
ENSMUST00000330621.1 ENSMUSG00000135523 ENSMUST00000330621.1 ENSMUSG00000135523 (from geneSymbol) uc336eio.1 uc336eio.1 
ENSMUST00000330624.1 Gm46404 ENSMUST00000330624.1 Gm46404 (from geneSymbol) uc336eir.1 uc336eir.1 
ENSMUST00000330628.1 ENSMUSG00000135524 ENSMUST00000330628.1 ENSMUSG00000135524 (from geneSymbol) uc336eiv.1 uc336eiv.1 
ENSMUST00000330629.1 ENSMUSG00000135525 ENSMUST00000330629.1 ENSMUSG00000135525 (from geneSymbol) uc336eiw.1 uc336eiw.1 
ENSMUST00000330630.1 Gm49707 ENSMUST00000330630.1 Gm49707 (from geneSymbol) uc336eix.1 uc336eix.1 
ENSMUST00000330635.1 ENSMUSG00000135526 ENSMUST00000330635.1 ENSMUSG00000135526 (from geneSymbol) uc336ejc.1 uc336ejc.1 
ENSMUST00000330636.1 ENSMUSG00000135527 ENSMUST00000330636.1 ENSMUSG00000135527 (from geneSymbol) uc336ejd.1 uc336ejd.1 
ENSMUST00000330640.1 ENSMUSG00000135528 ENSMUST00000330640.1 ENSMUSG00000135528 (from geneSymbol) uc336ejh.1 uc336ejh.1 
ENSMUST00000330643.1 ENSMUSG00000135529 ENSMUST00000330643.1 ENSMUSG00000135529 (from geneSymbol) uc336ejk.1 uc336ejk.1 
ENSMUST00000330646.1 ENSMUSG00000135530 ENSMUST00000330646.1 ENSMUSG00000135530 (from geneSymbol) uc336ejn.1 uc336ejn.1 
ENSMUST00000330648.1 ENSMUSG00000135531 ENSMUST00000330648.1 ENSMUSG00000135531 (from geneSymbol) uc336ejp.1 uc336ejp.1 
ENSMUST00000330649.1 ENSMUSG00000135532 ENSMUST00000330649.1 ENSMUSG00000135532 (from geneSymbol) uc336ejq.1 uc336ejq.1 
ENSMUST00000330650.1 ENSMUSG00000135533 ENSMUST00000330650.1 ENSMUSG00000135533 (from geneSymbol) uc336ejr.1 uc336ejr.1 
ENSMUST00000330667.1 ENSMUSG00000135534 ENSMUST00000330667.1 ENSMUSG00000135534 (from geneSymbol) uc336eki.1 uc336eki.1 
ENSMUST00000330671.1 Gm34059 ENSMUST00000330671.1 Gm34059 (from geneSymbol) uc336ekm.1 uc336ekm.1 
ENSMUST00000330728.1 ENSMUSG00000135535 ENSMUST00000330728.1 ENSMUSG00000135535 (from geneSymbol) uc336emr.1 uc336emr.1 
ENSMUST00000330730.1 ENSMUSG00000135536 ENSMUST00000330730.1 ENSMUSG00000135536 (from geneSymbol) uc336emt.1 uc336emt.1 
ENSMUST00000330731.1 ENSMUSG00000135537 ENSMUST00000330731.1 ENSMUSG00000135537 (from geneSymbol) uc336emu.1 uc336emu.1 
ENSMUST00000330735.1 ENSMUSG00000135538 ENSMUST00000330735.1 ENSMUSG00000135538 (from geneSymbol) uc336emy.1 uc336emy.1 
ENSMUST00000330737.1 ENSMUSG00000135539 ENSMUST00000330737.1 ENSMUSG00000135539 (from geneSymbol) uc336ena.1 uc336ena.1 
ENSMUST00000330738.1 ENSMUSG00000135540 ENSMUST00000330738.1 ENSMUSG00000135540 (from geneSymbol) uc336enb.1 uc336enb.1 
ENSMUST00000330761.1 ENSMUSG00000135541 ENSMUST00000330761.1 ENSMUSG00000135541 (from geneSymbol) uc336eny.1 uc336eny.1 
ENSMUST00000330763.1 ENSMUSG00000135542 ENSMUST00000330763.1 ENSMUSG00000135542 (from geneSymbol) uc336eoa.1 uc336eoa.1 
ENSMUST00000330765.1 ENSMUSG00000135543 ENSMUST00000330765.1 ENSMUSG00000135543 (from geneSymbol) uc336eoc.1 uc336eoc.1 
ENSMUST00000330767.1 ENSMUSG00000135544 ENSMUST00000330767.1 ENSMUSG00000135544 (from geneSymbol) uc336eoe.1 uc336eoe.1 
ENSMUST00000330771.1 1700019C18Rik ENSMUST00000330771.1 1700019C18Rik (from geneSymbol) AK006109 uc336eoi.1 uc336eoi.1 
ENSMUST00000330793.1 ENSMUSG00000135545 ENSMUST00000330793.1 ENSMUSG00000135545 (from geneSymbol) uc336epe.1 uc336epe.1 
ENSMUST00000330795.1 ENSMUSG00000135546 ENSMUST00000330795.1 ENSMUSG00000135546 (from geneSymbol) uc336epg.1 uc336epg.1 
ENSMUST00000330800.1 ENSMUSG00000135547 ENSMUST00000330800.1 ENSMUSG00000135547 (from geneSymbol) AK041297 uc336epl.1 uc336epl.1 
ENSMUST00000330801.1 ENSMUSG00000135548 ENSMUST00000330801.1 ENSMUSG00000135548 (from geneSymbol) uc336epm.1 uc336epm.1 
ENSMUST00000330802.1 ENSMUSG00000135549 ENSMUST00000330802.1 ENSMUSG00000135549 (from geneSymbol) uc336epn.1 uc336epn.1 
ENSMUST00000330805.1 Gm46447 ENSMUST00000330805.1 Gm46447 (from geneSymbol) AK138303 uc336epq.1 uc336epq.1 
ENSMUST00000330809.1 ENSMUSG00000135550 ENSMUST00000330809.1 ENSMUSG00000135550 (from geneSymbol) uc336epu.1 uc336epu.1 
ENSMUST00000330815.1 ENSMUSG00000135551 ENSMUST00000330815.1 ENSMUSG00000135551 (from geneSymbol) uc336eqa.1 uc336eqa.1 
ENSMUST00000330817.1 ENSMUSG00000135552 ENSMUST00000330817.1 ENSMUSG00000135552 (from geneSymbol) uc336eqc.1 uc336eqc.1 
ENSMUST00000330819.1 ENSMUSG00000135553 ENSMUST00000330819.1 ENSMUSG00000135553 (from geneSymbol) uc336eqe.1 uc336eqe.1 
ENSMUST00000330820.1 Gm36440 ENSMUST00000330820.1 Gm36440 (from geneSymbol) uc336eqf.1 uc336eqf.1 
ENSMUST00000330831.1 Gm16248 ENSMUST00000330831.1 Gm16248 (from geneSymbol) AK086128 uc336eqq.1 uc336eqq.1 
ENSMUST00000330838.1 ENSMUSG00000135554 ENSMUST00000330838.1 ENSMUSG00000135554 (from geneSymbol) uc336eqx.1 uc336eqx.1 
ENSMUST00000330839.1 ENSMUSG00000135555 ENSMUST00000330839.1 ENSMUSG00000135555 (from geneSymbol) uc336eqy.1 uc336eqy.1 
ENSMUST00000330841.1 ENSMUSG00000135556 ENSMUST00000330841.1 ENSMUSG00000135556 (from geneSymbol) LF194665 uc336era.1 uc336era.1 
ENSMUST00000330842.1 ENSMUSG00000135557 ENSMUST00000330842.1 ENSMUSG00000135557 (from geneSymbol) uc336erb.1 uc336erb.1 
ENSMUST00000330850.1 ENSMUSG00000135558 ENSMUST00000330850.1 ENSMUSG00000135558 (from geneSymbol) uc336erj.1 uc336erj.1 
ENSMUST00000330921.1 ENSMUSG00000135559 ENSMUST00000330921.1 ENSMUSG00000135559 (from geneSymbol) uc336euc.1 uc336euc.1 
ENSMUST00000330923.1 ENSMUSG00000135560 ENSMUST00000330923.1 ENSMUSG00000135560 (from geneSymbol) uc336eue.1 uc336eue.1 
ENSMUST00000330925.1 ENSMUSG00000135561 ENSMUST00000330925.1 ENSMUSG00000135561 (from geneSymbol) uc336eug.1 uc336eug.1 
ENSMUST00000330926.1 ENSMUSG00000135562 ENSMUST00000330926.1 ENSMUSG00000135562 (from geneSymbol) uc336euh.1 uc336euh.1 
ENSMUST00000330927.1 ENSMUSG00000135563 ENSMUST00000330927.1 ENSMUSG00000135563 (from geneSymbol) uc336eui.1 uc336eui.1 
ENSMUST00000330928.1 ENSMUSG00000135564 ENSMUST00000330928.1 ENSMUSG00000135564 (from geneSymbol) uc336euj.1 uc336euj.1 
ENSMUST00000330930.1 ENSMUSG00000135565 ENSMUST00000330930.1 ENSMUSG00000135565 (from geneSymbol) uc336eul.1 uc336eul.1 
ENSMUST00000330932.1 ENSMUSG00000135566 ENSMUST00000330932.1 ENSMUSG00000135566 (from geneSymbol) uc336eun.1 uc336eun.1 
ENSMUST00000330936.1 ENSMUSG00000135567 ENSMUST00000330936.1 ENSMUSG00000135567 (from geneSymbol) uc336eur.1 uc336eur.1 
ENSMUST00000330940.1 ENSMUSG00000135568 ENSMUST00000330940.1 ENSMUSG00000135568 (from geneSymbol) uc336euv.1 uc336euv.1 
ENSMUST00000330942.1 ENSMUSG00000135569 ENSMUST00000330942.1 ENSMUSG00000135569 (from geneSymbol) AK077166 uc336eux.1 uc336eux.1 
ENSMUST00000330972.1 Gm56843 ENSMUST00000330972.1 Gm56843 (from geneSymbol) uc336ewb.1 uc336ewb.1 
ENSMUST00000330987.1 Gm56782 ENSMUST00000330987.1 Gm56782 (from geneSymbol) uc336ewq.1 uc336ewq.1 
ENSMUST00000330988.1 ENSMUSG00000135570 ENSMUST00000330988.1 ENSMUSG00000135570 (from geneSymbol) uc336ewr.1 uc336ewr.1 
ENSMUST00000330990.1 ENSMUSG00000135571 ENSMUST00000330990.1 ENSMUSG00000135571 (from geneSymbol) uc336ewt.1 uc336ewt.1 
ENSMUST00000330991.1 ENSMUSG00000135572 ENSMUST00000330991.1 ENSMUSG00000135572 (from geneSymbol) uc336ewu.1 uc336ewu.1 
ENSMUST00000330994.1 ENSMUSG00000135573 ENSMUST00000330994.1 ENSMUSG00000135573 (from geneSymbol) uc336ewx.1 uc336ewx.1 
ENSMUST00000330995.1 ENSMUSG00000135574 ENSMUST00000330995.1 ENSMUSG00000135574 (from geneSymbol) uc336ewy.1 uc336ewy.1 
ENSMUST00000330998.1 ENSMUSG00000135575 ENSMUST00000330998.1 ENSMUSG00000135575 (from geneSymbol) uc336exb.1 uc336exb.1 
ENSMUST00000331001.1 ENSMUSG00000135576 ENSMUST00000331001.1 ENSMUSG00000135576 (from geneSymbol) uc336exe.1 uc336exe.1 
ENSMUST00000331003.1 ENSMUSG00000135577 ENSMUST00000331003.1 ENSMUSG00000135577 (from geneSymbol) uc336exg.1 uc336exg.1 
ENSMUST00000331010.1 ENSMUSG00000135578 ENSMUST00000331010.1 ENSMUSG00000135578 (from geneSymbol) uc336exn.1 uc336exn.1 
ENSMUST00000331063.1 ENSMUSG00000135579 ENSMUST00000331063.1 ENSMUSG00000135579 (from geneSymbol) uc336ezo.1 uc336ezo.1 
ENSMUST00000331069.1 ENSMUSG00000135580 ENSMUST00000331069.1 ENSMUSG00000135580 (from geneSymbol) uc336ezu.1 uc336ezu.1 
ENSMUST00000331070.1 ENSMUSG00000135581 ENSMUST00000331070.1 ENSMUSG00000135581 (from geneSymbol) uc336ezv.1 uc336ezv.1 
ENSMUST00000331071.1 ENSMUSG00000135582 ENSMUST00000331071.1 ENSMUSG00000135582 (from geneSymbol) uc336ezw.1 uc336ezw.1 
ENSMUST00000331072.1 ENSMUSG00000135583 ENSMUST00000331072.1 ENSMUSG00000135583 (from geneSymbol) uc336ezx.1 uc336ezx.1 
ENSMUST00000331073.1 ENSMUSG00000135584 ENSMUST00000331073.1 ENSMUSG00000135584 (from geneSymbol) uc336ezy.1 uc336ezy.1 
ENSMUST00000331076.1 ENSMUSG00000135585 ENSMUST00000331076.1 ENSMUSG00000135585 (from geneSymbol) uc336fab.1 uc336fab.1 
ENSMUST00000331088.1 ENSMUSG00000135586 ENSMUST00000331088.1 ENSMUSG00000135586 (from geneSymbol) uc336fan.1 uc336fan.1 
ENSMUST00000331091.1 ENSMUSG00000135587 ENSMUST00000331091.1 ENSMUSG00000135587 (from geneSymbol) uc336faq.1 uc336faq.1 
ENSMUST00000331094.1 ENSMUSG00000135588 ENSMUST00000331094.1 ENSMUSG00000135588 (from geneSymbol) uc336fat.1 uc336fat.1 
ENSMUST00000331109.1 4921501I09Rik ENSMUST00000331109.1 4921501I09Rik (from geneSymbol) AK019532 uc336fbi.1 uc336fbi.1 
ENSMUST00000331110.1 ENSMUSG00000135589 ENSMUST00000331110.1 ENSMUSG00000135589 (from geneSymbol) uc336fbj.1 uc336fbj.1 
ENSMUST00000331111.1 4933413C19Rik ENSMUST00000331111.1 4933413C19Rik (from geneSymbol) AK016799 uc336fbk.1 uc336fbk.1 
ENSMUST00000331114.1 ENSMUSG00000135590 ENSMUST00000331114.1 ENSMUSG00000135590 (from geneSymbol) uc336fbn.1 uc336fbn.1 
ENSMUST00000331126.1 ENSMUSG00000135591 ENSMUST00000331126.1 ENSMUSG00000135591 (from geneSymbol) uc336fbz.1 uc336fbz.1 
ENSMUST00000331129.1 ENSMUSG00000135592 ENSMUST00000331129.1 ENSMUSG00000135592 (from geneSymbol) uc336fcc.1 uc336fcc.1 
ENSMUST00000331135.1 Gm48623 ENSMUST00000331135.1 Gm48623 (from geneSymbol) uc336fci.1 uc336fci.1 
ENSMUST00000331155.1 Gm30021 ENSMUST00000331155.1 predicted gene, 30021 (from RefSeq NR_166768.1) NR_166768 uc336fdc.1 uc336fdc.1 
ENSMUST00000331156.1 ENSMUSG00000135594 ENSMUST00000331156.1 ENSMUSG00000135594 (from geneSymbol) uc336fdd.1 uc336fdd.1 
ENSMUST00000331157.1 ENSMUSG00000135595 ENSMUST00000331157.1 ENSMUSG00000135595 (from geneSymbol) uc336fde.1 uc336fde.1 
ENSMUST00000331158.1 ENSMUSG00000135596 ENSMUST00000331158.1 ENSMUSG00000135596 (from geneSymbol) uc336fdf.1 uc336fdf.1 
ENSMUST00000331159.1 ENSMUSG00000135597 ENSMUST00000331159.1 ENSMUSG00000135597 (from geneSymbol) uc336fdg.1 uc336fdg.1 
ENSMUST00000331165.1 ENSMUSG00000135598 ENSMUST00000331165.1 ENSMUSG00000135598 (from geneSymbol) uc336fdm.1 uc336fdm.1 
ENSMUST00000331175.1 Gm35695 ENSMUST00000331175.1 Gm35695 (from geneSymbol) AK076705 uc336fdw.1 uc336fdw.1 
ENSMUST00000331193.1 Gm32885 ENSMUST00000331193.1 Gm32885 (from geneSymbol) uc336feo.1 uc336feo.1 
ENSMUST00000331228.1 ENSMUSG00000135600 ENSMUST00000331228.1 ENSMUSG00000135600 (from geneSymbol) uc336ffx.1 uc336ffx.1 
ENSMUST00000331229.1 ENSMUSG00000135601 ENSMUST00000331229.1 ENSMUSG00000135601 (from geneSymbol) uc336ffy.1 uc336ffy.1 
ENSMUST00000331230.1 ENSMUSG00000135602 ENSMUST00000331230.1 ENSMUSG00000135602 (from geneSymbol) uc336ffz.1 uc336ffz.1 
ENSMUST00000331231.1 Gm381 ENSMUST00000331231.1 Gm381 (from geneSymbol) uc336fga.1 uc336fga.1 
ENSMUST00000331232.1 ENSMUSG00000135604 ENSMUST00000331232.1 ENSMUSG00000135604 (from geneSymbol) uc336fgb.1 uc336fgb.1 
ENSMUST00000331234.1 Gm56925 ENSMUST00000331234.1 Gm56925 (from geneSymbol) uc336fgd.1 uc336fgd.1 
ENSMUST00000331238.1 ENSMUSG00000135605 ENSMUST00000331238.1 ENSMUSG00000135605 (from geneSymbol) uc336fgh.1 uc336fgh.1 
ENSMUST00000331250.1 ENSMUSG00000135606 ENSMUST00000331250.1 ENSMUSG00000135606 (from geneSymbol) uc336fgt.1 uc336fgt.1 
ENSMUST00000331257.1 Gm26795 ENSMUST00000331257.1 Gm26795 (from geneSymbol) AK037200 uc336fha.1 uc336fha.1 
ENSMUST00000331263.1 ENSMUSG00000135608 ENSMUST00000331263.1 ENSMUSG00000135608 (from geneSymbol) uc336fhf.1 uc336fhf.1 
ENSMUST00000331264.1 ENSMUSG00000135609 ENSMUST00000331264.1 ENSMUSG00000135609 (from geneSymbol) uc336fhg.1 uc336fhg.1 
ENSMUST00000331269.1 ENSMUSG00000135610 ENSMUST00000331269.1 ENSMUSG00000135610 (from geneSymbol) uc336fhl.1 uc336fhl.1 
ENSMUST00000331272.1 Gm17232 ENSMUST00000331272.1 Gm17232 (from geneSymbol) uc336fho.1 uc336fho.1 
ENSMUST00000331273.1 ENSMUSG00000135611 ENSMUST00000331273.1 ENSMUSG00000135611 (from geneSymbol) uc336fhp.1 uc336fhp.1 
ENSMUST00000331275.1 ENSMUSG00000135612 ENSMUST00000331275.1 ENSMUSG00000135612 (from geneSymbol) uc336fhr.1 uc336fhr.1 
ENSMUST00000331277.1 ENSMUSG00000135613 ENSMUST00000331277.1 ENSMUSG00000135613 (from geneSymbol) uc336fht.1 uc336fht.1 
ENSMUST00000331281.1 ENSMUSG00000135614 ENSMUST00000331281.1 ENSMUSG00000135614 (from geneSymbol) uc336fhx.1 uc336fhx.1 
ENSMUST00000331283.1 ENSMUSG00000135615 ENSMUST00000331283.1 ENSMUSG00000135615 (from geneSymbol) uc336fhz.1 uc336fhz.1 
ENSMUST00000331285.1 ENSMUSG00000135616 ENSMUST00000331285.1 ENSMUSG00000135616 (from geneSymbol) uc336fib.1 uc336fib.1 
ENSMUST00000331294.1 ENSMUSG00000135617 ENSMUST00000331294.1 ENSMUSG00000135617 (from geneSymbol) uc336fik.1 uc336fik.1 
ENSMUST00000331296.1 ENSMUSG00000135618 ENSMUST00000331296.1 ENSMUSG00000135618 (from geneSymbol) uc336fim.1 uc336fim.1 
ENSMUST00000331297.1 ENSMUSG00000135619 ENSMUST00000331297.1 ENSMUSG00000135619 (from geneSymbol) AK013159 uc336fin.1 uc336fin.1 
ENSMUST00000331298.1 ENSMUSG00000135620 ENSMUST00000331298.1 ENSMUSG00000135620 (from geneSymbol) uc336fio.1 uc336fio.1 
ENSMUST00000331299.1 ENSMUSG00000135621 ENSMUST00000331299.1 ENSMUSG00000135621 (from geneSymbol) uc336fip.1 uc336fip.1 
ENSMUST00000331300.1 Gm49390 ENSMUST00000331300.1 Gm49390 (from geneSymbol) AK080112 uc336fiq.1 uc336fiq.1 
ENSMUST00000331346.1 ENSMUSG00000135622 ENSMUST00000331346.1 ENSMUSG00000135622 (from geneSymbol) uc336fkk.1 uc336fkk.1 
ENSMUST00000331347.1 ENSMUSG00000135623 ENSMUST00000331347.1 ENSMUSG00000135623 (from geneSymbol) uc336fkl.1 uc336fkl.1 
ENSMUST00000331352.1 ENSMUSG00000135624 ENSMUST00000331352.1 ENSMUSG00000135624 (from geneSymbol) uc336fkq.1 uc336fkq.1 
ENSMUST00000331360.1 ENSMUSG00000135625 ENSMUST00000331360.1 ENSMUSG00000135625 (from geneSymbol) uc336fky.1 uc336fky.1 
ENSMUST00000331362.1 ENSMUSG00000135626 ENSMUST00000331362.1 ENSMUSG00000135626 (from geneSymbol) uc336fla.1 uc336fla.1 
ENSMUST00000331369.1 ENSMUSG00000135627 ENSMUST00000331369.1 ENSMUSG00000135627 (from geneSymbol) uc336flh.1 uc336flh.1 
ENSMUST00000331370.1 ENSMUSG00000135628 ENSMUST00000331370.1 ENSMUSG00000135628 (from geneSymbol) uc336fli.1 uc336fli.1 
ENSMUST00000331374.1 ENSMUSG00000135629 ENSMUST00000331374.1 ENSMUSG00000135629 (from geneSymbol) uc336flm.1 uc336flm.1 
ENSMUST00000331378.1 ENSMUSG00000135630 ENSMUST00000331378.1 ENSMUSG00000135630 (from geneSymbol) uc336flq.1 uc336flq.1 
ENSMUST00000331380.1 ENSMUSG00000135631 ENSMUST00000331380.1 ENSMUSG00000135631 (from geneSymbol) uc336fls.1 uc336fls.1 
ENSMUST00000331381.1 ENSMUSG00000135632 ENSMUST00000331381.1 ENSMUSG00000135632 (from geneSymbol) uc336flt.1 uc336flt.1 
ENSMUST00000331384.1 Gm16578 ENSMUST00000331384.1 Gm16578 (from geneSymbol) uc336flw.1 uc336flw.1 
ENSMUST00000331400.1 ENSMUSG00000135633 ENSMUST00000331400.1 ENSMUSG00000135633 (from geneSymbol) uc336fmm.1 uc336fmm.1 
ENSMUST00000331402.1 ENSMUSG00000135635 ENSMUST00000331402.1 ENSMUSG00000135635 (from geneSymbol) uc336fmn.1 uc336fmn.1 
ENSMUST00000331407.1 ENSMUSG00000135636 ENSMUST00000331407.1 ENSMUSG00000135636 (from geneSymbol) uc336fms.1 uc336fms.1 
ENSMUST00000331410.1 ENSMUSG00000135637 ENSMUST00000331410.1 ENSMUSG00000135637 (from geneSymbol) uc336fmv.1 uc336fmv.1 
ENSMUST00000331413.1 ENSMUSG00000135638 ENSMUST00000331413.1 ENSMUSG00000135638 (from geneSymbol) uc336fmy.1 uc336fmy.1 
ENSMUST00000331414.1 ENSMUSG00000135639 ENSMUST00000331414.1 ENSMUSG00000135639 (from geneSymbol) uc336fmz.1 uc336fmz.1 
ENSMUST00000331419.1 ENSMUSG00000135640 ENSMUST00000331419.1 ENSMUSG00000135640 (from geneSymbol) uc336fne.1 uc336fne.1 
ENSMUST00000331428.1 ENSMUSG00000135641 ENSMUST00000331428.1 ENSMUSG00000135641 (from geneSymbol) uc336fnn.1 uc336fnn.1 
ENSMUST00000331434.1 ENSMUSG00000121747 ENSMUST00000331434.1 ENSMUSG00000121747 (from geneSymbol) AK049985 uc336fns.1 uc336fns.1 
ENSMUST00000331443.1 ENSMUSG00000135642 ENSMUST00000331443.1 ENSMUSG00000135642 (from geneSymbol) uc336fob.1 uc336fob.1 
ENSMUST00000331444.1 ENSMUSG00000135643 ENSMUST00000331444.1 ENSMUSG00000135643 (from geneSymbol) AK017899 uc336foc.1 uc336foc.1 
ENSMUST00000331451.1 ENSMUSG00000135644 ENSMUST00000331451.1 ENSMUSG00000135644 (from geneSymbol) uc336foj.1 uc336foj.1 
ENSMUST00000331453.1 ENSMUSG00000135645 ENSMUST00000331453.1 ENSMUSG00000135645 (from geneSymbol) DM175487 uc336fol.1 uc336fol.1 
ENSMUST00000331476.1 ENSMUSG00000135646 ENSMUST00000331476.1 ENSMUSG00000135646 (from geneSymbol) uc336fpi.1 uc336fpi.1 
ENSMUST00000331477.1 ENSMUSG00000135647 ENSMUST00000331477.1 ENSMUSG00000135647 (from geneSymbol) uc336fpj.1 uc336fpj.1 
ENSMUST00000331482.1 ENSMUSG00000135648 ENSMUST00000331482.1 ENSMUSG00000135648 (from geneSymbol) uc336fpo.1 uc336fpo.1 
ENSMUST00000331485.1 ENSMUSG00000135649 ENSMUST00000331485.1 ENSMUSG00000135649 (from geneSymbol) uc336fpr.1 uc336fpr.1 
ENSMUST00000331486.1 ENSMUSG00000135650 ENSMUST00000331486.1 ENSMUSG00000135650 (from geneSymbol) uc336fps.1 uc336fps.1 
ENSMUST00000331491.1 Gm34343 ENSMUST00000331491.1 Gm34343 (from geneSymbol) uc336fpx.1 uc336fpx.1 
ENSMUST00000331497.1 ENSMUSG00000135651 ENSMUST00000331497.1 ENSMUSG00000135651 (from geneSymbol) uc336fqd.1 uc336fqd.1 
ENSMUST00000331502.1 1700048M11Rik ENSMUST00000331502.1 1700048M11Rik (from geneSymbol) AK006730 uc336fqi.1 uc336fqi.1 
ENSMUST00000331504.1 ENSMUSG00000135652 ENSMUST00000331504.1 ENSMUSG00000135652 (from geneSymbol) uc336fqk.1 uc336fqk.1 
ENSMUST00000331507.1 ENSMUSG00000135653 ENSMUST00000331507.1 ENSMUSG00000135653 (from geneSymbol) uc336fqn.1 uc336fqn.1 
ENSMUST00000331509.1 ENSMUSG00000135654 ENSMUST00000331509.1 ENSMUSG00000135654 (from geneSymbol) uc336fqp.1 uc336fqp.1 
ENSMUST00000331515.1 ENSMUSG00000135655 ENSMUST00000331515.1 ENSMUSG00000135655 (from geneSymbol) uc336fqv.1 uc336fqv.1 
ENSMUST00000331516.1 Gm33969 ENSMUST00000331516.1 Gm33969 (from geneSymbol) uc336fqw.1 uc336fqw.1 
ENSMUST00000331524.1 ENSMUSG00000135656 ENSMUST00000331524.1 ENSMUSG00000135656 (from geneSymbol) uc336fre.1 uc336fre.1 
ENSMUST00000331525.1 ENSMUSG00000135657 ENSMUST00000331525.1 ENSMUSG00000135657 (from geneSymbol) uc336frf.1 uc336frf.1 
ENSMUST00000331527.1 Gm20659 ENSMUST00000331527.1 Gm20659 (from geneSymbol) uc336frh.1 uc336frh.1 
ENSMUST00000331529.1 ENSMUSG00000135658 ENSMUST00000331529.1 ENSMUSG00000135658 (from geneSymbol) uc336frj.1 uc336frj.1 
ENSMUST00000331531.1 Gm46458 ENSMUST00000331531.1 Gm46458 (from geneSymbol) uc336frk.1 uc336frk.1 
ENSMUST00000331551.1 ENSMUSG00000135660 ENSMUST00000331551.1 ENSMUSG00000135660 (from geneSymbol) uc336fsd.1 uc336fsd.1 
ENSMUST00000331552.1 ENSMUSG00000135661 ENSMUST00000331552.1 ENSMUSG00000135661 (from geneSymbol) uc336fse.1 uc336fse.1 
ENSMUST00000331554.1 ENSMUSG00000135662 ENSMUST00000331554.1 ENSMUSG00000135662 (from geneSymbol) uc336fsg.1 uc336fsg.1 
ENSMUST00000331555.1 ENSMUSG00000135663 ENSMUST00000331555.1 ENSMUSG00000135663 (from geneSymbol) uc336fsh.1 uc336fsh.1 
ENSMUST00000331556.1 ENSMUSG00000135664 ENSMUST00000331556.1 ENSMUSG00000135664 (from geneSymbol) uc336fsi.1 uc336fsi.1 
ENSMUST00000331557.1 ENSMUSG00000135665 ENSMUST00000331557.1 ENSMUSG00000135665 (from geneSymbol) uc336fsj.1 uc336fsj.1 
ENSMUST00000331558.1 ENSMUSG00000135666 ENSMUST00000331558.1 ENSMUSG00000135666 (from geneSymbol) uc336fsk.1 uc336fsk.1 
ENSMUST00000331559.1 ENSMUSG00000135667 ENSMUST00000331559.1 ENSMUSG00000135667 (from geneSymbol) uc336fsl.1 uc336fsl.1 
ENSMUST00000331566.1 ENSMUSG00000135668 ENSMUST00000331566.1 ENSMUSG00000135668 (from geneSymbol) uc336fss.1 uc336fss.1 
ENSMUST00000331573.1 ENSMUSG00000135669 ENSMUST00000331573.1 ENSMUSG00000135669 (from geneSymbol) uc336fsz.1 uc336fsz.1 
ENSMUST00000331574.1 ENSMUSG00000135670 ENSMUST00000331574.1 ENSMUSG00000135670 (from geneSymbol) uc336fta.1 uc336fta.1 
ENSMUST00000331575.1 ENSMUSG00000135671 ENSMUST00000331575.1 ENSMUSG00000135671 (from geneSymbol) uc336ftb.1 uc336ftb.1 
ENSMUST00000331576.1 ENSMUSG00000135672 ENSMUST00000331576.1 ENSMUSG00000135672 (from geneSymbol) uc336ftc.1 uc336ftc.1 
ENSMUST00000331581.1 Gm26672 ENSMUST00000331581.1 Gm26672 (from geneSymbol) uc336fth.1 uc336fth.1 
ENSMUST00000331582.1 Wbscr25 ENSMUST00000331582.1 Wbscr25 (from geneSymbol) AY081954 uc336fti.1 uc336fti.1 
ENSMUST00000331584.1 ENSMUSG00000135673 ENSMUST00000331584.1 ENSMUSG00000135673 (from geneSymbol) uc336ftk.1 uc336ftk.1 
ENSMUST00000331586.1 ENSMUSG00000135674 ENSMUST00000331586.1 ENSMUSG00000135674 (from geneSymbol) uc336ftm.1 uc336ftm.1 
ENSMUST00000331592.1 ENSMUSG00000135675 ENSMUST00000331592.1 ENSMUSG00000135675 (from geneSymbol) uc336fts.1 uc336fts.1 
ENSMUST00000331594.1 ENSMUSG00000135676 ENSMUST00000331594.1 ENSMUSG00000135676 (from geneSymbol) uc336ftu.1 uc336ftu.1 
ENSMUST00000331595.1 ENSMUSG00000135677 ENSMUST00000331595.1 ENSMUSG00000135677 (from geneSymbol) uc336ftv.1 uc336ftv.1 
ENSMUST00000331597.1 ENSMUSG00000135678 ENSMUST00000331597.1 ENSMUSG00000135678 (from geneSymbol) uc336ftx.1 uc336ftx.1 
ENSMUST00000331674.1 Gm56828 ENSMUST00000331674.1 Gm56828 (from geneSymbol) uc336fwv.1 uc336fwv.1 
ENSMUST00000331677.1 ENSMUSG00000135680 ENSMUST00000331677.1 ENSMUSG00000135680 (from geneSymbol) uc336fwy.1 uc336fwy.1 
ENSMUST00000331678.1 ENSMUSG00000135681 ENSMUST00000331678.1 ENSMUSG00000135681 (from geneSymbol) uc336fwz.1 uc336fwz.1 
ENSMUST00000331679.1 ENSMUSG00000135682 ENSMUST00000331679.1 ENSMUSG00000135682 (from geneSymbol) uc336fxa.1 uc336fxa.1 
ENSMUST00000331681.1 ENSMUSG00000135683 ENSMUST00000331681.1 ENSMUSG00000135683 (from geneSymbol) uc336fxc.1 uc336fxc.1 
ENSMUST00000331696.1 ENSMUSG00000135684 ENSMUST00000331696.1 ENSMUSG00000135684 (from geneSymbol) uc336fxr.1 uc336fxr.1 
ENSMUST00000331704.1 ENSMUSG00000135685 ENSMUST00000331704.1 ENSMUSG00000135685 (from geneSymbol) uc336fxz.1 uc336fxz.1 
ENSMUST00000331705.1 ENSMUSG00000135686 ENSMUST00000331705.1 ENSMUSG00000135686 (from geneSymbol) uc336fya.1 uc336fya.1 
ENSMUST00000331711.1 ENSMUSG00000135687 ENSMUST00000331711.1 ENSMUSG00000135687 (from geneSymbol) uc336fyg.1 uc336fyg.1 
ENSMUST00000331714.1 6030442K20Rik ENSMUST00000331714.1 6030442K20Rik (from geneSymbol) AK050872 uc336fyj.1 uc336fyj.1 
ENSMUST00000331731.1 ENSMUSG00000135688 ENSMUST00000331731.1 ENSMUSG00000135688 (from geneSymbol) uc336fza.1 uc336fza.1 
ENSMUST00000331732.1 ENSMUSG00000135689 ENSMUST00000331732.1 ENSMUSG00000135689 (from geneSymbol) uc336fzb.1 uc336fzb.1 
ENSMUST00000331797.1 ENSMUSG00000135690 ENSMUST00000331797.1 ENSMUSG00000135690 (from geneSymbol) uc336gbo.1 uc336gbo.1 
ENSMUST00000331799.1 ENSMUSG00000135691 ENSMUST00000331799.1 ENSMUSG00000135691 (from geneSymbol) uc336gbq.1 uc336gbq.1 
ENSMUST00000331812.1 ENSMUSG00000135692 ENSMUST00000331812.1 ENSMUSG00000135692 (from geneSymbol) uc336gcd.1 uc336gcd.1 
ENSMUST00000331813.1 ENSMUSG00000135693 ENSMUST00000331813.1 ENSMUSG00000135693 (from geneSymbol) uc336gce.1 uc336gce.1 
ENSMUST00000331814.1 Gm56949 ENSMUST00000331814.1 Gm56949 (from geneSymbol) uc336gcf.1 uc336gcf.1 
ENSMUST00000331819.1 ENSMUSG00000135694 ENSMUST00000331819.1 ENSMUSG00000135694 (from geneSymbol) uc336gck.1 uc336gck.1 
ENSMUST00000331820.1 ENSMUSG00000135695 ENSMUST00000331820.1 ENSMUSG00000135695 (from geneSymbol) uc336gcl.1 uc336gcl.1 
ENSMUST00000331826.1 ENSMUSG00000135696 ENSMUST00000331826.1 ENSMUSG00000135696 (from geneSymbol) uc336gcr.1 uc336gcr.1 
ENSMUST00000331853.1 4930572G02Rik ENSMUST00000331853.1 4930572G02Rik (from geneSymbol) KY467697 uc336gds.1 uc336gds.1 
ENSMUST00000331885.1 ENSMUSG00000135697 ENSMUST00000331885.1 ENSMUSG00000135697 (from geneSymbol) uc336gey.1 uc336gey.1 
ENSMUST00000331886.1 ENSMUSG00000135698 ENSMUST00000331886.1 ENSMUSG00000135698 (from geneSymbol) uc336gez.1 uc336gez.1 
ENSMUST00000331888.1 ENSMUSG00000135699 ENSMUST00000331888.1 ENSMUSG00000135699 (from geneSymbol) uc336gfb.1 uc336gfb.1 
ENSMUST00000331889.1 ENSMUSG00000135700 ENSMUST00000331889.1 ENSMUSG00000135700 (from geneSymbol) uc336gfc.1 uc336gfc.1 
ENSMUST00000331890.1 ENSMUSG00000135701 ENSMUST00000331890.1 ENSMUSG00000135701 (from geneSymbol) uc336gfd.1 uc336gfd.1 
ENSMUST00000331892.1 ENSMUSG00000135702 ENSMUST00000331892.1 ENSMUSG00000135702 (from geneSymbol) uc336gff.1 uc336gff.1 
ENSMUST00000331893.1 ENSMUSG00000135703 ENSMUST00000331893.1 ENSMUSG00000135703 (from geneSymbol) uc336gfg.1 uc336gfg.1 
ENSMUST00000331896.1 4930432H08Rik ENSMUST00000331896.1 4930432H08Rik (from geneSymbol) uc336gfj.1 uc336gfj.1 
ENSMUST00000331920.1 ENSMUSG00000135704 ENSMUST00000331920.1 ENSMUSG00000135704 (from geneSymbol) uc336ggh.1 uc336ggh.1 
ENSMUST00000331924.1 ENSMUSG00000135705 ENSMUST00000331924.1 ENSMUSG00000135705 (from geneSymbol) uc336ggl.1 uc336ggl.1 
ENSMUST00000331925.1 ENSMUSG00000135706 ENSMUST00000331925.1 ENSMUSG00000135706 (from geneSymbol) uc336ggm.1 uc336ggm.1 
ENSMUST00000331929.1 Gm14488 ENSMUST00000331929.1 Gm14488 (from geneSymbol) AK040965 uc336ggq.1 uc336ggq.1 
ENSMUST00000331936.1 2610035F20Rik ENSMUST00000331936.1 2610035F20Rik (from geneSymbol) AK042842 uc336ggx.1 uc336ggx.1 
ENSMUST00000331949.1 Gm29994 ENSMUST00000331949.1 Gm29994 (from geneSymbol) uc336ghk.1 uc336ghk.1 
ENSMUST00000331952.1 ENSMUSG00000135707 ENSMUST00000331952.1 ENSMUSG00000135707 (from geneSymbol) uc336ghn.1 uc336ghn.1 
ENSMUST00000331956.1 ENSMUSG00000135708 ENSMUST00000331956.1 ENSMUSG00000135708 (from geneSymbol) uc336ghr.1 uc336ghr.1 
ENSMUST00000331959.1 ENSMUSG00000135709 ENSMUST00000331959.1 ENSMUSG00000135709 (from geneSymbol) uc336ghu.1 uc336ghu.1 
ENSMUST00000331962.1 1810012K16Rik ENSMUST00000331962.1 1810012K16Rik (from geneSymbol) AK007460 uc336ghx.1 uc336ghx.1 
ENSMUST00000331965.1 1700041M05Rik ENSMUST00000331965.1 1700041M05Rik (from geneSymbol) uc336gia.1 uc336gia.1 
ENSMUST00000331979.1 ENSMUSG00000135710 ENSMUST00000331979.1 ENSMUSG00000135710 (from geneSymbol) uc336gio.1 uc336gio.1 
ENSMUST00000331986.1 1700086D15Rik ENSMUST00000331986.1 1700086D15Rik (from geneSymbol) AK007013 uc336giu.1 uc336giu.1 
ENSMUST00000332008.1 ENSMUSG00000135711 ENSMUST00000332008.1 ENSMUSG00000135711 (from geneSymbol) uc336gjq.1 uc336gjq.1 
ENSMUST00000332012.1 ENSMUSG00000135712 ENSMUST00000332012.1 ENSMUSG00000135712 (from geneSymbol) uc336gju.1 uc336gju.1 
ENSMUST00000332017.1 ENSMUSG00000135713 ENSMUST00000332017.1 ENSMUSG00000135713 (from geneSymbol) uc336gjz.1 uc336gjz.1 
ENSMUST00000332019.1 ENSMUSG00000135714 ENSMUST00000332019.1 ENSMUSG00000135714 (from geneSymbol) uc336gkb.1 uc336gkb.1 
ENSMUST00000332021.1 1700039M10Rik ENSMUST00000332021.1 1700039M10Rik (from geneSymbol) AK006644 uc336gkd.1 uc336gkd.1 
ENSMUST00000332028.1 ENSMUSG00000135715 ENSMUST00000332028.1 ENSMUSG00000135715 (from geneSymbol) uc336gkk.1 uc336gkk.1 
ENSMUST00000332030.1 ENSMUSG00000135716 ENSMUST00000332030.1 ENSMUSG00000135716 (from geneSymbol) uc336gkm.1 uc336gkm.1 
ENSMUST00000332037.1 ENSMUSG00000135717 ENSMUST00000332037.1 ENSMUSG00000135717 (from geneSymbol) uc336gkt.1 uc336gkt.1 
ENSMUST00000332039.1 ENSMUSG00000135718 ENSMUST00000332039.1 ENSMUSG00000135718 (from geneSymbol) uc336gku.1 uc336gku.1 
ENSMUST00000332043.1 ENSMUSG00000135719 ENSMUST00000332043.1 ENSMUSG00000135719 (from geneSymbol) uc336gkx.1 uc336gkx.1 
ENSMUST00000332044.1 ENSMUSG00000135720 ENSMUST00000332044.1 ENSMUSG00000135720 (from geneSymbol) uc336gky.1 uc336gky.1 
ENSMUST00000332045.1 ENSMUSG00000135721 ENSMUST00000332045.1 ENSMUSG00000135721 (from geneSymbol) AK132841 uc336gkz.1 uc336gkz.1 
ENSMUST00000332049.1 ENSMUSG00000135722 ENSMUST00000332049.1 ENSMUSG00000135722 (from geneSymbol) uc336gld.1 uc336gld.1 
ENSMUST00000332052.1 ENSMUSG00000135723 ENSMUST00000332052.1 ENSMUSG00000135723 (from geneSymbol) uc336glg.1 uc336glg.1 
ENSMUST00000332061.1 ENSMUSG00000135724 ENSMUST00000332061.1 ENSMUSG00000135724 (from geneSymbol) uc336glp.1 uc336glp.1 
ENSMUST00000332067.1 ENSMUSG00000135725 ENSMUST00000332067.1 ENSMUSG00000135725 (from geneSymbol) uc336glv.1 uc336glv.1 
ENSMUST00000332068.1 ENSMUSG00000135726 ENSMUST00000332068.1 ENSMUSG00000135726 (from geneSymbol) uc336glw.1 uc336glw.1 
ENSMUST00000332069.1 ENSMUSG00000135727 ENSMUST00000332069.1 ENSMUSG00000135727 (from geneSymbol) uc336glx.1 uc336glx.1 
ENSMUST00000332072.1 3110099E03Rik ENSMUST00000332072.1 3110099E03Rik (from geneSymbol) AK019444 uc336gma.1 uc336gma.1 
ENSMUST00000332107.1 ENSMUSG00000135729 ENSMUST00000332107.1 ENSMUSG00000135729 (from geneSymbol) uc336gni.1 uc336gni.1 
ENSMUST00000332109.1 ENSMUSG00000135730 ENSMUST00000332109.1 ENSMUSG00000135730 (from geneSymbol) uc336gnk.1 uc336gnk.1 
ENSMUST00000332111.1 ENSMUSG00000135731 ENSMUST00000332111.1 ENSMUSG00000135731 (from geneSymbol) uc336gnm.1 uc336gnm.1 
ENSMUST00000332112.1 ENSMUSG00000135732 ENSMUST00000332112.1 ENSMUSG00000135732 (from geneSymbol) uc336gnn.1 uc336gnn.1 
ENSMUST00000332113.1 ENSMUSG00000135733 ENSMUST00000332113.1 ENSMUSG00000135733 (from geneSymbol) uc336gno.1 uc336gno.1 
ENSMUST00000332114.1 ENSMUSG00000135734 ENSMUST00000332114.1 ENSMUSG00000135734 (from geneSymbol) uc336gnp.1 uc336gnp.1 
ENSMUST00000332115.1 4921509A06Rik ENSMUST00000332115.1 4921509A06Rik (from geneSymbol) uc336gnq.1 uc336gnq.1 
ENSMUST00000332117.1 Gm36823 ENSMUST00000332117.1 Gm36823 (from geneSymbol) AK134652 uc336gns.1 uc336gns.1 
ENSMUST00000332120.1 ENSMUSG00000135735 ENSMUST00000332120.1 ENSMUSG00000135735 (from geneSymbol) uc336gnv.1 uc336gnv.1 
ENSMUST00000332124.1 4930458A03Rik ENSMUST00000332124.1 4930458A03Rik (from geneSymbol) AK076789 uc336gnz.1 uc336gnz.1 
ENSMUST00000332150.1 ENSMUSG00000135736 ENSMUST00000332150.1 ENSMUSG00000135736 (from geneSymbol) AK142636 uc336goz.1 uc336goz.1 
ENSMUST00000332159.1 ENSMUSG00000135737 ENSMUST00000332159.1 ENSMUSG00000135737 (from geneSymbol) uc336gpi.1 uc336gpi.1 
ENSMUST00000332162.1 ENSMUSG00000135738 ENSMUST00000332162.1 ENSMUSG00000135738 (from geneSymbol) uc336gpl.1 uc336gpl.1 
ENSMUST00000332163.1 ENSMUSG00000135739 ENSMUST00000332163.1 ENSMUSG00000135739 (from geneSymbol) uc336gpm.1 uc336gpm.1 
ENSMUST00000332170.1 ENSMUSG00000135740 ENSMUST00000332170.1 ENSMUSG00000135740 (from geneSymbol) uc336gpt.1 uc336gpt.1 
ENSMUST00000332171.1 ENSMUSG00000135741 ENSMUST00000332171.1 ENSMUSG00000135741 (from geneSymbol) uc336gpu.1 uc336gpu.1 
ENSMUST00000332173.1 ENSMUSG00000135742 ENSMUST00000332173.1 ENSMUSG00000135742 (from geneSymbol) uc336gpw.1 uc336gpw.1 
ENSMUST00000332174.1 Gm16295 ENSMUST00000332174.1 Gm16295 (from geneSymbol) uc336gpx.1 uc336gpx.1 
ENSMUST00000332179.1 ENSMUSG00000135743 ENSMUST00000332179.1 ENSMUSG00000135743 (from geneSymbol) uc336gqc.1 uc336gqc.1 
ENSMUST00000332182.1 ENSMUSG00000135744 ENSMUST00000332182.1 ENSMUSG00000135744 (from geneSymbol) uc336gqf.1 uc336gqf.1 
ENSMUST00000332183.1 ENSMUSG00000135745 ENSMUST00000332183.1 ENSMUSG00000135745 (from geneSymbol) uc336gqg.1 uc336gqg.1 
ENSMUST00000332184.1 ENSMUSG00000135746 ENSMUST00000332184.1 ENSMUSG00000135746 (from geneSymbol) uc336gqh.1 uc336gqh.1 
ENSMUST00000332185.1 ENSMUSG00000135747 ENSMUST00000332185.1 ENSMUSG00000135747 (from geneSymbol) uc336gqi.1 uc336gqi.1 
ENSMUST00000332187.1 ENSMUSG00000135748 ENSMUST00000332187.1 ENSMUSG00000135748 (from geneSymbol) uc336gqk.1 uc336gqk.1 
ENSMUST00000332188.1 ENSMUSG00000135749 ENSMUST00000332188.1 ENSMUSG00000135749 (from geneSymbol) uc336gql.1 uc336gql.1 
ENSMUST00000332190.1 ENSMUSG00000135750 ENSMUST00000332190.1 ENSMUSG00000135750 (from geneSymbol) uc336gqn.1 uc336gqn.1 
ENSMUST00000332191.1 ENSMUSG00000135751 ENSMUST00000332191.1 ENSMUSG00000135751 (from geneSymbol) uc336gqo.1 uc336gqo.1 
ENSMUST00000332192.1 ENSMUSG00000135752 ENSMUST00000332192.1 ENSMUSG00000135752 (from geneSymbol) uc336gqp.1 uc336gqp.1 
ENSMUST00000332193.1 ENSMUSG00000135753 ENSMUST00000332193.1 ENSMUSG00000135753 (from geneSymbol) uc336gqq.1 uc336gqq.1 
ENSMUST00000332194.1 ENSMUSG00000135754 ENSMUST00000332194.1 ENSMUSG00000135754 (from geneSymbol) uc336gqr.1 uc336gqr.1 
ENSMUST00000332196.1 ENSMUSG00000135755 ENSMUST00000332196.1 ENSMUSG00000135755 (from geneSymbol) uc336gqt.1 uc336gqt.1 
ENSMUST00000332201.1 ENSMUSG00000135756 ENSMUST00000332201.1 ENSMUSG00000135756 (from geneSymbol) uc336gqy.1 uc336gqy.1 
ENSMUST00000332202.1 ENSMUSG00000135757 ENSMUST00000332202.1 ENSMUSG00000135757 (from geneSymbol) uc336gqz.1 uc336gqz.1 
ENSMUST00000332203.1 ENSMUSG00000135758 ENSMUST00000332203.1 ENSMUSG00000135758 (from geneSymbol) uc336gra.1 uc336gra.1 
ENSMUST00000332204.1 ENSMUSG00000135759 ENSMUST00000332204.1 ENSMUSG00000135759 (from geneSymbol) uc336grb.1 uc336grb.1 
ENSMUST00000332205.1 ENSMUSG00000135760 ENSMUST00000332205.1 ENSMUSG00000135760 (from geneSymbol) uc336grc.1 uc336grc.1 
ENSMUST00000332206.1 ENSMUSG00000135761 ENSMUST00000332206.1 ENSMUSG00000135761 (from geneSymbol) uc336grd.1 uc336grd.1 
ENSMUST00000332210.1 ENSMUSG00000135763 ENSMUST00000332210.1 ENSMUSG00000135763 (from geneSymbol) uc336grg.1 uc336grg.1 
ENSMUST00000332214.1 ENSMUSG00000135764 ENSMUST00000332214.1 ENSMUSG00000135764 (from geneSymbol) uc336grk.1 uc336grk.1 
ENSMUST00000332215.1 ENSMUSG00000135765 ENSMUST00000332215.1 ENSMUSG00000135765 (from geneSymbol) uc336grl.1 uc336grl.1 
ENSMUST00000332220.1 ENSMUSG00000135766 ENSMUST00000332220.1 ENSMUSG00000135766 (from geneSymbol) uc336grq.1 uc336grq.1 
ENSMUST00000332221.1 ENSMUSG00000135767 ENSMUST00000332221.1 ENSMUSG00000135767 (from geneSymbol) uc336grr.1 uc336grr.1 
ENSMUST00000332226.1 Gm5122 ENSMUST00000332226.1 Gm5122 (from geneSymbol) AK040484 uc336grv.1 uc336grv.1 
ENSMUST00000332228.1 ENSMUSG00000135769 ENSMUST00000332228.1 ENSMUSG00000135769 (from geneSymbol) uc336grx.1 uc336grx.1 
ENSMUST00000332235.1 Gm49476 ENSMUST00000332235.1 Gm49476 (from geneSymbol) AK019740 uc336gse.1 uc336gse.1 
ENSMUST00000332248.1 ENSMUSG00000135770 ENSMUST00000332248.1 ENSMUSG00000135770 (from geneSymbol) uc336gsr.1 uc336gsr.1 
ENSMUST00000332250.1 ENSMUSG00000135771 ENSMUST00000332250.1 ENSMUSG00000135771 (from geneSymbol) uc336gst.1 uc336gst.1 
ENSMUST00000332252.1 ENSMUSG00000135772 ENSMUST00000332252.1 ENSMUSG00000135772 (from geneSymbol) uc336gsv.1 uc336gsv.1 
ENSMUST00000332253.1 ENSMUSG00000135773 ENSMUST00000332253.1 ENSMUSG00000135773 (from geneSymbol) uc336gsw.1 uc336gsw.1 
ENSMUST00000332255.1 Gm47938 ENSMUST00000332255.1 Gm47938 (from geneSymbol) AK054532 uc336gsy.1 uc336gsy.1 
ENSMUST00000332257.1 ENSMUSG00000135774 ENSMUST00000332257.1 ENSMUSG00000135774 (from geneSymbol) uc336gta.1 uc336gta.1 
ENSMUST00000332258.1 ENSMUSG00000135775 ENSMUST00000332258.1 ENSMUSG00000135775 (from geneSymbol) uc336gtb.1 uc336gtb.1 
ENSMUST00000332259.1 1700120E14Rik ENSMUST00000332259.1 RIKEN cDNA 1700120E14 gene (from RefSeq NR_045368.1) NR_045368 uc336gtc.1 uc336gtc.1 
ENSMUST00000332260.1 ENSMUSG00000135776 ENSMUST00000332260.1 ENSMUSG00000135776 (from geneSymbol) uc336gtd.1 uc336gtd.1 
ENSMUST00000332264.1 ENSMUSG00000135777 ENSMUST00000332264.1 ENSMUSG00000135777 (from geneSymbol) LF256431 uc336gth.1 uc336gth.1 
ENSMUST00000332266.1 ENSMUSG00000135778 ENSMUST00000332266.1 ENSMUSG00000135778 (from geneSymbol) uc336gtj.1 uc336gtj.1 
ENSMUST00000332273.1 ENSMUSG00000135779 ENSMUST00000332273.1 ENSMUSG00000135779 (from geneSymbol) uc336gtq.1 uc336gtq.1 
ENSMUST00000332275.1 ENSMUSG00000135780 ENSMUST00000332275.1 ENSMUSG00000135780 (from geneSymbol) uc336gts.1 uc336gts.1 
ENSMUST00000332277.1 ENSMUSG00000135781 ENSMUST00000332277.1 ENSMUSG00000135781 (from geneSymbol) uc336gtu.1 uc336gtu.1 
ENSMUST00000332278.1 ENSMUSG00000135782 ENSMUST00000332278.1 ENSMUSG00000135782 (from geneSymbol) uc336gtv.1 uc336gtv.1 
ENSMUST00000332280.1 ENSMUSG00000135783 ENSMUST00000332280.1 ENSMUSG00000135783 (from geneSymbol) uc336gtx.1 uc336gtx.1 
ENSMUST00000332281.1 ENSMUSG00000135784 ENSMUST00000332281.1 ENSMUSG00000135784 (from geneSymbol) uc336gty.1 uc336gty.1 
ENSMUST00000332282.1 ENSMUSG00000135785 ENSMUST00000332282.1 ENSMUSG00000135785 (from geneSymbol) uc336gtz.1 uc336gtz.1 
ENSMUST00000332285.1 ENSMUSG00000135786 ENSMUST00000332285.1 ENSMUSG00000135786 (from geneSymbol) uc336guc.1 uc336guc.1 
ENSMUST00000332293.1 ENSMUSG00000135787 ENSMUST00000332293.1 ENSMUSG00000135787 (from geneSymbol) LF194788 uc336guk.1 uc336guk.1 
ENSMUST00000332295.1 ENSMUSG00000135788 ENSMUST00000332295.1 ENSMUSG00000135788 (from geneSymbol) uc336gum.1 uc336gum.1 
ENSMUST00000332296.1 ENSMUSG00000135789 ENSMUST00000332296.1 ENSMUSG00000135789 (from geneSymbol) uc336gun.1 uc336gun.1 
ENSMUST00000332297.1 ENSMUSG00000135790 ENSMUST00000332297.1 ENSMUSG00000135790 (from geneSymbol) uc336guo.1 uc336guo.1 
ENSMUST00000332299.1 ENSMUSG00000135791 ENSMUST00000332299.1 ENSMUSG00000135791 (from geneSymbol) uc336guq.1 uc336guq.1 
ENSMUST00000332300.1 ENSMUSG00000135792 ENSMUST00000332300.1 ENSMUSG00000135792 (from geneSymbol) uc336gur.1 uc336gur.1 
ENSMUST00000332301.1 ENSMUSG00000135793 ENSMUST00000332301.1 ENSMUSG00000135793 (from geneSymbol) uc336gus.1 uc336gus.1 
ENSMUST00000332306.1 ENSMUSG00000135794 ENSMUST00000332306.1 ENSMUSG00000135794 (from geneSymbol) uc336gux.1 uc336gux.1 
ENSMUST00000332307.1 ENSMUSG00000135795 ENSMUST00000332307.1 ENSMUSG00000135795 (from geneSymbol) AK016409 uc336guy.1 uc336guy.1 
ENSMUST00000332316.1 Gm34342 ENSMUST00000332316.1 Gm34342 (from geneSymbol) uc336gvh.1 uc336gvh.1 
ENSMUST00000332319.1 1700010B13Rik ENSMUST00000332319.1 1700010B13Rik (from geneSymbol) uc336gvk.1 uc336gvk.1 
ENSMUST00000332325.1 ENSMUSG00000135796 ENSMUST00000332325.1 ENSMUSG00000135796 (from geneSymbol) uc336gvq.1 uc336gvq.1 
ENSMUST00000332346.1 ENSMUSG00000135797 ENSMUST00000332346.1 ENSMUSG00000135797 (from geneSymbol) uc336gwl.1 uc336gwl.1 
ENSMUST00000332349.1 ENSMUSG00000135798 ENSMUST00000332349.1 ENSMUSG00000135798 (from geneSymbol) uc336gwo.1 uc336gwo.1 
ENSMUST00000332361.1 ENSMUSG00000135799 ENSMUST00000332361.1 ENSMUSG00000135799 (from geneSymbol) uc336gxa.1 uc336gxa.1 
ENSMUST00000332362.1 ENSMUSG00000135800 ENSMUST00000332362.1 ENSMUSG00000135800 (from geneSymbol) uc336gxb.1 uc336gxb.1 
ENSMUST00000332364.1 ENSMUSG00000135801 ENSMUST00000332364.1 ENSMUSG00000135801 (from geneSymbol) uc336gxd.1 uc336gxd.1 
ENSMUST00000332365.1 ENSMUSG00000135802 ENSMUST00000332365.1 ENSMUSG00000135802 (from geneSymbol) uc336gxe.1 uc336gxe.1 
ENSMUST00000332367.1 ENSMUSG00000135803 ENSMUST00000332367.1 ENSMUSG00000135803 (from geneSymbol) uc336gxg.1 uc336gxg.1 
ENSMUST00000332368.1 ENSMUSG00000135804 ENSMUST00000332368.1 ENSMUSG00000135804 (from geneSymbol) uc336gxh.1 uc336gxh.1 
ENSMUST00000332370.1 ENSMUSG00000135805 ENSMUST00000332370.1 ENSMUSG00000135805 (from geneSymbol) uc336gxj.1 uc336gxj.1 
ENSMUST00000332372.1 ENSMUSG00000135806 ENSMUST00000332372.1 ENSMUSG00000135806 (from geneSymbol) uc336gxl.1 uc336gxl.1 
ENSMUST00000332374.1 ENSMUSG00000135807 ENSMUST00000332374.1 ENSMUSG00000135807 (from geneSymbol) uc336gxn.1 uc336gxn.1 
ENSMUST00000332378.1 ENSMUSG00000135808 ENSMUST00000332378.1 ENSMUSG00000135808 (from geneSymbol) uc336gxr.1 uc336gxr.1 
ENSMUST00000332379.1 ENSMUSG00000135809 ENSMUST00000332379.1 ENSMUSG00000135809 (from geneSymbol) uc336gxs.1 uc336gxs.1 
ENSMUST00000332380.1 ENSMUSG00000135810 ENSMUST00000332380.1 ENSMUSG00000135810 (from geneSymbol) BC049683 uc336gxt.1 uc336gxt.1 
ENSMUST00000332381.1 ENSMUSG00000135811 ENSMUST00000332381.1 ENSMUSG00000135811 (from geneSymbol) uc336gxu.1 uc336gxu.1 
ENSMUST00000332382.1 ENSMUSG00000135812 ENSMUST00000332382.1 ENSMUSG00000135812 (from geneSymbol) uc336gxv.1 uc336gxv.1 
ENSMUST00000332383.1 ENSMUSG00000135813 ENSMUST00000332383.1 ENSMUSG00000135813 (from geneSymbol) uc336gxw.1 uc336gxw.1 
ENSMUST00000332387.1 ENSMUSG00000135814 ENSMUST00000332387.1 ENSMUSG00000135814 (from geneSymbol) uc336gya.1 uc336gya.1 
ENSMUST00000332391.1 ENSMUSG00000135815 ENSMUST00000332391.1 ENSMUSG00000135815 (from geneSymbol) uc336gye.1 uc336gye.1 
ENSMUST00000332392.1 ENSMUSG00000135816 ENSMUST00000332392.1 ENSMUSG00000135816 (from geneSymbol) uc336gyf.1 uc336gyf.1 
ENSMUST00000332393.1 1700031A10Rik ENSMUST00000332393.1 1700031A10Rik (from geneSymbol) AK006574 uc336gyg.1 uc336gyg.1 
ENSMUST00000332396.1 ENSMUSG00000135817 ENSMUST00000332396.1 ENSMUSG00000135817 (from geneSymbol) uc336gyj.1 uc336gyj.1 
ENSMUST00000332397.1 ENSMUSG00000135818 ENSMUST00000332397.1 ENSMUSG00000135818 (from geneSymbol) uc336gyk.1 uc336gyk.1 
ENSMUST00000332398.1 ENSMUSG00000135819 ENSMUST00000332398.1 ENSMUSG00000135819 (from geneSymbol) uc336gyl.1 uc336gyl.1 
ENSMUST00000332399.1 ENSMUSG00000135820 ENSMUST00000332399.1 ENSMUSG00000135820 (from geneSymbol) uc336gym.1 uc336gym.1 
ENSMUST00000332400.1 ENSMUSG00000135821 ENSMUST00000332400.1 ENSMUSG00000135821 (from geneSymbol) uc336gyn.1 uc336gyn.1 
ENSMUST00000332403.1 Gm5817 ENSMUST00000332403.1 Gm5817 (from geneSymbol) uc336gyq.1 uc336gyq.1 
ENSMUST00000332421.1 ENSMUSG00000135822 ENSMUST00000332421.1 ENSMUSG00000135822 (from geneSymbol) uc336gzi.1 uc336gzi.1 
ENSMUST00000332425.1 ENSMUSG00000135823 ENSMUST00000332425.1 ENSMUSG00000135823 (from geneSymbol) uc336gzm.1 uc336gzm.1 
ENSMUST00000332426.1 ENSMUSG00000135824 ENSMUST00000332426.1 ENSMUSG00000135824 (from geneSymbol) uc336gzn.1 uc336gzn.1 
ENSMUST00000332428.1 Gm57324 ENSMUST00000332428.1 Gm57324 (from geneSymbol) uc336gzp.1 uc336gzp.1 
ENSMUST00000332437.1 Gt(ROSA)26Sor ENSMUST00000332437.1 Gt(ROSA)26Sor (from geneSymbol) AK021028 uc336gzy.1 uc336gzy.1 
ENSMUST00000332454.1 ENSMUSG00000135825 ENSMUST00000332454.1 ENSMUSG00000135825 (from geneSymbol) uc336hap.1 uc336hap.1 
ENSMUST00000332456.1 ENSMUSG00000135826 ENSMUST00000332456.1 ENSMUSG00000135826 (from geneSymbol) uc336haq.1 uc336haq.1 
ENSMUST00000332482.1 ENSMUSG00000135827 ENSMUST00000332482.1 ENSMUSG00000135827 (from geneSymbol) uc336hbe.1 uc336hbe.1 
ENSMUST00000332483.1 ENSMUSG00000135828 ENSMUST00000332483.1 ENSMUSG00000135828 (from geneSymbol) uc336hbf.1 uc336hbf.1 
ENSMUST00000332492.1 ENSMUSG00000135829 ENSMUST00000332492.1 ENSMUSG00000135829 (from geneSymbol) uc336hbo.1 uc336hbo.1 
ENSMUST00000332493.1 Gm17197 ENSMUST00000332493.1 Gm17197 (from geneSymbol) uc336hbp.1 uc336hbp.1 
ENSMUST00000332502.1 ENSMUSG00000135830 ENSMUST00000332502.1 ENSMUSG00000135830 (from geneSymbol) uc336hby.1 uc336hby.1 
ENSMUST00000332503.1 ENSMUSG00000135831 ENSMUST00000332503.1 ENSMUSG00000135831 (from geneSymbol) uc336hbz.1 uc336hbz.1 
ENSMUST00000332504.1 ENSMUSG00000135832 ENSMUST00000332504.1 ENSMUSG00000135832 (from geneSymbol) uc336hca.1 uc336hca.1 
ENSMUST00000332505.1 ENSMUSG00000135833 ENSMUST00000332505.1 ENSMUSG00000135833 (from geneSymbol) uc336hcb.1 uc336hcb.1 
ENSMUST00000332514.1 ENSMUSG00000135834 ENSMUST00000332514.1 ENSMUSG00000135834 (from geneSymbol) uc336hck.1 uc336hck.1 
ENSMUST00000332528.1 ENSMUSG00000135835 ENSMUST00000332528.1 ENSMUSG00000135835 (from geneSymbol) uc336hcy.1 uc336hcy.1 
ENSMUST00000332533.1 ENSMUSG00000135836 ENSMUST00000332533.1 ENSMUSG00000135836 (from geneSymbol) uc336hdd.1 uc336hdd.1 
ENSMUST00000332536.1 ENSMUSG00000135837 ENSMUST00000332536.1 ENSMUSG00000135837 (from geneSymbol) uc336hdg.1 uc336hdg.1 
ENSMUST00000332540.1 ENSMUSG00000135838 ENSMUST00000332540.1 ENSMUSG00000135838 (from geneSymbol) uc336hdk.1 uc336hdk.1 
ENSMUST00000332580.1 ENSMUSG00000135839 ENSMUST00000332580.1 ENSMUSG00000135839 (from geneSymbol) uc336hew.1 uc336hew.1 
ENSMUST00000332583.1 ENSMUSG00000135840 ENSMUST00000332583.1 ENSMUSG00000135840 (from geneSymbol) uc336hez.1 uc336hez.1 
ENSMUST00000332588.1 ENSMUSG00000135841 ENSMUST00000332588.1 ENSMUSG00000135841 (from geneSymbol) uc336hfe.1 uc336hfe.1 
ENSMUST00000332589.1 ENSMUSG00000135842 ENSMUST00000332589.1 ENSMUSG00000135842 (from geneSymbol) uc336hff.1 uc336hff.1 
ENSMUST00000332593.1 ENSMUSG00000135843 ENSMUST00000332593.1 ENSMUSG00000135843 (from geneSymbol) uc336hfj.1 uc336hfj.1 
ENSMUST00000332597.1 Gm36608 ENSMUST00000332597.1 Gm36608 (from geneSymbol) AK144662 uc336hfn.1 uc336hfn.1 
ENSMUST00000332600.1 ENSMUSG00000135844 ENSMUST00000332600.1 ENSMUSG00000135844 (from geneSymbol) uc336hfq.1 uc336hfq.1 
ENSMUST00000332601.1 Gm30505 ENSMUST00000332601.1 Gm30505 (from geneSymbol) AK149453 uc336hfr.1 uc336hfr.1 
ENSMUST00000332616.1 ENSMUSG00000135845 ENSMUST00000332616.1 ENSMUSG00000135845 (from geneSymbol) uc336hgg.1 uc336hgg.1 
ENSMUST00000332617.1 ENSMUSG00000135846 ENSMUST00000332617.1 ENSMUSG00000135846 (from geneSymbol) uc336hgh.1 uc336hgh.1 
ENSMUST00000332623.1 ENSMUSG00000135847 ENSMUST00000332623.1 ENSMUSG00000135847 (from geneSymbol) uc336hgn.1 uc336hgn.1 
ENSMUST00000332624.1 ENSMUSG00000135848 ENSMUST00000332624.1 ENSMUSG00000135848 (from geneSymbol) uc336hgo.1 uc336hgo.1 
ENSMUST00000332626.1 ENSMUSG00000135849 ENSMUST00000332626.1 ENSMUSG00000135849 (from geneSymbol) uc336hgq.1 uc336hgq.1 
ENSMUST00000332659.1 ENSMUSG00000135850 ENSMUST00000332659.1 ENSMUSG00000135850 (from geneSymbol) uc336hhx.1 uc336hhx.1 
ENSMUST00000332660.1 ENSMUSG00000135851 ENSMUST00000332660.1 ENSMUSG00000135851 (from geneSymbol) uc336hhy.1 uc336hhy.1 
ENSMUST00000332661.1 ENSMUSG00000135852 ENSMUST00000332661.1 ENSMUSG00000135852 (from geneSymbol) uc336hhz.1 uc336hhz.1 
ENSMUST00000332662.1 ENSMUSG00000135853 ENSMUST00000332662.1 ENSMUSG00000135853 (from geneSymbol) uc336hia.1 uc336hia.1 
ENSMUST00000332665.1 ENSMUSG00000135854 ENSMUST00000332665.1 ENSMUSG00000135854 (from geneSymbol) uc336hid.1 uc336hid.1 
ENSMUST00000332669.1 ENSMUSG00000135855 ENSMUST00000332669.1 ENSMUSG00000135855 (from geneSymbol) uc336hih.1 uc336hih.1 
ENSMUST00000332670.1 ENSMUSG00000135856 ENSMUST00000332670.1 ENSMUSG00000135856 (from geneSymbol) uc336hii.1 uc336hii.1 
ENSMUST00000332671.1 Gm27162 ENSMUST00000332671.1 Gm27162 (from geneSymbol) AK039836 uc336hij.1 uc336hij.1 
ENSMUST00000332682.1 ENSMUSG00000135857 ENSMUST00000332682.1 ENSMUSG00000135857 (from geneSymbol) uc336hiu.1 uc336hiu.1 
ENSMUST00000332684.1 ENSMUSG00000135858 ENSMUST00000332684.1 ENSMUSG00000135858 (from geneSymbol) uc336hiw.1 uc336hiw.1 
ENSMUST00000332685.1 ENSMUSG00000135859 ENSMUST00000332685.1 ENSMUSG00000135859 (from geneSymbol) uc336hix.1 uc336hix.1 
ENSMUST00000332689.1 ENSMUSG00000135860 ENSMUST00000332689.1 ENSMUSG00000135860 (from geneSymbol) uc336hjb.1 uc336hjb.1 
ENSMUST00000332690.1 ENSMUSG00000135861 ENSMUST00000332690.1 ENSMUSG00000135861 (from geneSymbol) uc336hjc.1 uc336hjc.1 
ENSMUST00000332691.1 ENSMUSG00000135862 ENSMUST00000332691.1 ENSMUSG00000135862 (from geneSymbol) uc336hjd.1 uc336hjd.1 
ENSMUST00000332698.1 ENSMUSG00000135863 ENSMUST00000332698.1 ENSMUSG00000135863 (from geneSymbol) uc336hjk.1 uc336hjk.1 
ENSMUST00000332699.1 ENSMUSG00000135864 ENSMUST00000332699.1 ENSMUSG00000135864 (from geneSymbol) uc336hjl.1 uc336hjl.1 
ENSMUST00000332711.1 ENSMUSG00000135865 ENSMUST00000332711.1 ENSMUSG00000135865 (from geneSymbol) uc336hjx.1 uc336hjx.1 
ENSMUST00000332713.1 ENSMUSG00000135866 ENSMUST00000332713.1 ENSMUSG00000135866 (from geneSymbol) LF200678 uc336hjz.1 uc336hjz.1 
ENSMUST00000332714.1 ENSMUSG00000135867 ENSMUST00000332714.1 ENSMUSG00000135867 (from geneSymbol) uc336hka.1 uc336hka.1 
ENSMUST00000332717.1 ENSMUSG00000135869 ENSMUST00000332717.1 ENSMUSG00000135869 (from geneSymbol) uc336hkc.1 uc336hkc.1 
ENSMUST00000332718.1 ENSMUSG00000135870 ENSMUST00000332718.1 ENSMUSG00000135870 (from geneSymbol) uc336hkd.1 uc336hkd.1 
ENSMUST00000332719.1 ENSMUSG00000135871 ENSMUST00000332719.1 ENSMUSG00000135871 (from geneSymbol) uc336hke.1 uc336hke.1 
ENSMUST00000332720.1 ENSMUSG00000135872 ENSMUST00000332720.1 ENSMUSG00000135872 (from geneSymbol) uc336hkf.1 uc336hkf.1 
ENSMUST00000332724.1 Gm46603 ENSMUST00000332724.1 Gm46603 (from geneSymbol) uc336hkj.1 uc336hkj.1 
ENSMUST00000332726.1 ENSMUSG00000135873 ENSMUST00000332726.1 ENSMUSG00000135873 (from geneSymbol) uc336hkl.1 uc336hkl.1 
ENSMUST00000332732.1 ENSMUSG00000135874 ENSMUST00000332732.1 predicted gene, 34647 (from RefSeq NR_168727.1) NR_168727 uc336hkr.1 uc336hkr.1 
ENSMUST00000332737.1 ENSMUSG00000135875 ENSMUST00000332737.1 ENSMUSG00000135875 (from geneSymbol) uc336hkw.1 uc336hkw.1 
ENSMUST00000332738.1 ENSMUSG00000135876 ENSMUST00000332738.1 ENSMUSG00000135876 (from geneSymbol) uc336hkx.1 uc336hkx.1 
ENSMUST00000332739.1 ENSMUSG00000135877 ENSMUST00000332739.1 ENSMUSG00000135877 (from geneSymbol) uc336hky.1 uc336hky.1 
ENSMUST00000332744.1 ENSMUSG00000135878 ENSMUST00000332744.1 ENSMUSG00000135878 (from geneSymbol) uc336hld.1 uc336hld.1 
ENSMUST00000332745.1 ENSMUSG00000135879 ENSMUST00000332745.1 ENSMUSG00000135879 (from geneSymbol) AK044315 uc336hle.1 uc336hle.1 
ENSMUST00000332752.1 ENSMUSG00000135880 ENSMUST00000332752.1 ENSMUSG00000135880 (from geneSymbol) uc336hll.1 uc336hll.1 
ENSMUST00000332753.1 ENSMUSG00000135881 ENSMUST00000332753.1 ENSMUSG00000135881 (from geneSymbol) uc336hlm.1 uc336hlm.1 
ENSMUST00000332754.1 ENSMUSG00000135882 ENSMUST00000332754.1 ENSMUSG00000135882 (from geneSymbol) uc336hln.1 uc336hln.1 
ENSMUST00000332765.1 Gm2916 ENSMUST00000332765.1 Gm2916 (from geneSymbol) uc336hlo.1 uc336hlo.1 
ENSMUST00000332782.1 Gm32364 ENSMUST00000332782.1 Gm32364 (from geneSymbol) uc336hmf.1 uc336hmf.1 
ENSMUST00000332793.1 ENSMUSG00000135886 ENSMUST00000332793.1 ENSMUSG00000135886 (from geneSymbol) uc336hmo.1 uc336hmo.1 
ENSMUST00000332794.1 ENSMUSG00000135887 ENSMUST00000332794.1 ENSMUSG00000135887 (from geneSymbol) DQ685504 uc336hmp.1 uc336hmp.1 
ENSMUST00000332795.1 ENSMUSG00000135888 ENSMUST00000332795.1 ENSMUSG00000135888 (from geneSymbol) uc336hmq.1 uc336hmq.1 
ENSMUST00000332798.1 ENSMUSG00000135889 ENSMUST00000332798.1 ENSMUSG00000135889 (from geneSymbol) uc336hmt.1 uc336hmt.1 
ENSMUST00000332800.1 ENSMUSG00000135890 ENSMUST00000332800.1 ENSMUSG00000135890 (from geneSymbol) uc336hmv.1 uc336hmv.1 
ENSMUST00000332802.1 ENSMUSG00000135892 ENSMUST00000332802.1 ENSMUSG00000135892 (from geneSymbol) uc336hmw.1 uc336hmw.1 
ENSMUST00000332804.1 ENSMUSG00000135893 ENSMUST00000332804.1 ENSMUSG00000135893 (from geneSymbol) uc336hmy.1 uc336hmy.1 
ENSMUST00000332809.1 ENSMUSG00000135894 ENSMUST00000332809.1 ENSMUSG00000135894 (from geneSymbol) uc336hnd.1 uc336hnd.1 
ENSMUST00000332811.1 ENSMUSG00000135895 ENSMUST00000332811.1 ENSMUSG00000135895 (from geneSymbol) uc336hnf.1 uc336hnf.1 
ENSMUST00000332817.1 ENSMUSG00000135896 ENSMUST00000332817.1 ENSMUSG00000135896 (from geneSymbol) uc336hnl.1 uc336hnl.1 
ENSMUST00000332829.1 ENSMUSG00000135897 ENSMUST00000332829.1 ENSMUSG00000135897 (from geneSymbol) uc336hnx.1 uc336hnx.1 
ENSMUST00000332830.1 ENSMUSG00000135898 ENSMUST00000332830.1 ENSMUSG00000135898 (from geneSymbol) uc336hny.1 uc336hny.1 
ENSMUST00000332831.1 ENSMUSG00000135899 ENSMUST00000332831.1 ENSMUSG00000135899 (from geneSymbol) uc336hnz.1 uc336hnz.1 
ENSMUST00000332836.1 ENSMUSG00000135900 ENSMUST00000332836.1 ENSMUSG00000135900 (from geneSymbol) uc336hoe.1 uc336hoe.1 
ENSMUST00000332837.1 ENSMUSG00000135901 ENSMUST00000332837.1 ENSMUSG00000135901 (from geneSymbol) uc336hof.1 uc336hof.1 
ENSMUST00000332838.1 ENSMUSG00000135902 ENSMUST00000332838.1 ENSMUSG00000135902 (from geneSymbol) uc336hog.1 uc336hog.1 
ENSMUST00000332839.1 ENSMUSG00000135903 ENSMUST00000332839.1 ENSMUSG00000135903 (from geneSymbol) uc336hoh.1 uc336hoh.1 
ENSMUST00000332840.1 ENSMUSG00000135904 ENSMUST00000332840.1 ENSMUSG00000135904 (from geneSymbol) uc336hoi.1 uc336hoi.1 
ENSMUST00000332841.1 ENSMUSG00000135905 ENSMUST00000332841.1 ENSMUSG00000135905 (from geneSymbol) uc336hoj.1 uc336hoj.1 
ENSMUST00000332843.1 ENSMUSG00000135906 ENSMUST00000332843.1 ENSMUSG00000135906 (from geneSymbol) uc336hol.1 uc336hol.1 
ENSMUST00000332844.1 ENSMUSG00000135907 ENSMUST00000332844.1 ENSMUSG00000135907 (from geneSymbol) uc336hom.1 uc336hom.1 
ENSMUST00000332845.1 Gm31224 ENSMUST00000332845.1 Gm31224 (from geneSymbol) uc336hon.1 uc336hon.1 
ENSMUST00000332855.1 ENSMUSG00000135908 ENSMUST00000332855.1 ENSMUSG00000135908 (from geneSymbol) uc336hox.1 uc336hox.1 
ENSMUST00000332856.1 ENSMUSG00000135909 ENSMUST00000332856.1 ENSMUSG00000135909 (from geneSymbol) uc336hoy.1 uc336hoy.1 
ENSMUST00000332857.1 ENSMUSG00000135910 ENSMUST00000332857.1 ENSMUSG00000135910 (from geneSymbol) uc336hoz.1 uc336hoz.1 
ENSMUST00000332858.1 ENSMUSG00000135911 ENSMUST00000332858.1 ENSMUSG00000135911 (from geneSymbol) uc336hpa.1 uc336hpa.1 
ENSMUST00000332883.1 4930547M16Rik ENSMUST00000332883.1 4930547M16Rik (from geneSymbol) AK036704 uc336hpz.1 uc336hpz.1 
ENSMUST00000332896.1 ENSMUSG00000135912 ENSMUST00000332896.1 ENSMUSG00000135912 (from geneSymbol) uc336hqm.1 uc336hqm.1 
ENSMUST00000332897.1 ENSMUSG00000135913 ENSMUST00000332897.1 ENSMUSG00000135913 (from geneSymbol) uc336hqn.1 uc336hqn.1 
ENSMUST00000332901.1 ENSMUSG00000135914 ENSMUST00000332901.1 ENSMUSG00000135914 (from geneSymbol) uc336hqq.1 uc336hqq.1 
ENSMUST00000332902.1 ENSMUSG00000135915 ENSMUST00000332902.1 ENSMUSG00000135915 (from geneSymbol) uc336hqr.1 uc336hqr.1 
ENSMUST00000332904.1 ENSMUSG00000135916 ENSMUST00000332904.1 ENSMUSG00000135916 (from geneSymbol) uc336hqt.1 uc336hqt.1 
ENSMUST00000332916.1 Gm26886 ENSMUST00000332916.1 Gm26886 (from geneSymbol) AK015236 uc336hrf.1 uc336hrf.1 
ENSMUST00000332924.1 4930563J15Rik ENSMUST00000332924.1 4930563J15Rik (from geneSymbol) AK016208 uc336hrn.1 uc336hrn.1 
ENSMUST00000332929.1 ENSMUSG00000135917 ENSMUST00000332929.1 ENSMUSG00000135917 (from geneSymbol) uc336hrs.1 uc336hrs.1 
ENSMUST00000332940.1 Gm38171 ENSMUST00000332940.1 Gm38171 (from geneSymbol) uc336hsd.1 uc336hsd.1 
ENSMUST00000332949.1 ENSMUSG00000135918 ENSMUST00000332949.1 ENSMUSG00000135918 (from geneSymbol) uc336hsm.1 uc336hsm.1 
ENSMUST00000332952.1 ENSMUSG00000135919 ENSMUST00000332952.1 ENSMUSG00000135919 (from geneSymbol) uc336hsp.1 uc336hsp.1 
ENSMUST00000332953.1 ENSMUSG00000135920 ENSMUST00000332953.1 ENSMUSG00000135920 (from geneSymbol) uc336hsq.1 uc336hsq.1 
ENSMUST00000332954.1 ENSMUSG00000135921 ENSMUST00000332954.1 ENSMUSG00000135921 (from geneSymbol) uc336hsr.1 uc336hsr.1 
ENSMUST00000332955.1 ENSMUSG00000135922 ENSMUST00000332955.1 ENSMUSG00000135922 (from geneSymbol) uc336hss.1 uc336hss.1 
ENSMUST00000332957.1 ENSMUSG00000135923 ENSMUST00000332957.1 ENSMUSG00000135923 (from geneSymbol) uc336hsu.1 uc336hsu.1 
ENSMUST00000332987.1 3110053B16Rik ENSMUST00000332987.1 3110053B16Rik (from geneSymbol) AK148766 uc336htx.1 uc336htx.1 
ENSMUST00000333008.1 ENSMUSG00000135924 ENSMUST00000333008.1 ENSMUSG00000135924 (from geneSymbol) LF195040 uc336hus.1 uc336hus.1 
ENSMUST00000333012.1 Gm35107 ENSMUST00000333012.1 Gm35107 (from geneSymbol) KY468247 uc336huw.1 uc336huw.1 
ENSMUST00000333039.1 ENSMUSG00000135925 ENSMUST00000333039.1 ENSMUSG00000135925 (from geneSymbol) uc336hvx.1 uc336hvx.1 
ENSMUST00000333043.1 ENSMUSG00000135926 ENSMUST00000333043.1 ENSMUSG00000135926 (from geneSymbol) uc336hwb.1 uc336hwb.1 
ENSMUST00000333045.1 ENSMUSG00000135927 ENSMUST00000333045.1 ENSMUSG00000135927 (from geneSymbol) uc336hwd.1 uc336hwd.1 
ENSMUST00000333046.1 ENSMUSG00000135928 ENSMUST00000333046.1 ENSMUSG00000135928 (from geneSymbol) uc336hwe.1 uc336hwe.1 
ENSMUST00000333058.1 Gm37294 ENSMUST00000333058.1 Gm37294 (from geneSymbol) uc336hwq.1 uc336hwq.1 
ENSMUST00000333125.1 ENSMUSG00000135929 ENSMUST00000333125.1 ENSMUSG00000135929 (from geneSymbol) AK042763 uc336hzf.1 uc336hzf.1 
ENSMUST00000333127.1 ENSMUSG00000135930 ENSMUST00000333127.1 ENSMUSG00000135930 (from geneSymbol) uc336hzh.1 uc336hzh.1 
ENSMUST00000333133.1 ENSMUSG00000135931 ENSMUST00000333133.1 ENSMUSG00000135931 (from geneSymbol) uc336hzn.1 uc336hzn.1 
ENSMUST00000333134.1 ENSMUSG00000135932 ENSMUST00000333134.1 ENSMUSG00000135932 (from geneSymbol) LF198456 uc336hzo.1 uc336hzo.1 
ENSMUST00000333135.1 ENSMUSG00000135933 ENSMUST00000333135.1 ENSMUSG00000135933 (from geneSymbol) uc336hzp.1 uc336hzp.1 
ENSMUST00000333137.1 ENSMUSG00000135934 ENSMUST00000333137.1 ENSMUSG00000135934 (from geneSymbol) uc336hzr.1 uc336hzr.1 
ENSMUST00000333140.1 ENSMUSG00000135935 ENSMUST00000333140.1 ENSMUSG00000135935 (from geneSymbol) uc336hzu.1 uc336hzu.1 
ENSMUST00000333141.1 5730405O15Rik ENSMUST00000333141.1 5730405O15Rik (from geneSymbol) AK134096 uc336hzv.1 uc336hzv.1 
ENSMUST00000333143.1 ENSMUSG00000135936 ENSMUST00000333143.1 ENSMUSG00000135936 (from geneSymbol) uc336hzx.1 uc336hzx.1 
ENSMUST00000333148.1 ENSMUSG00000135937 ENSMUST00000333148.1 ENSMUSG00000135937 (from geneSymbol) uc336iac.1 uc336iac.1 
ENSMUST00000333149.1 ENSMUSG00000135938 ENSMUST00000333149.1 ENSMUSG00000135938 (from geneSymbol) uc336iad.1 uc336iad.1 
ENSMUST00000333155.1 Gm13200 ENSMUST00000333155.1 Gm13200 (from geneSymbol) uc336iaj.1 uc336iaj.1 
ENSMUST00000333167.1 ENSMUSG00000135939 ENSMUST00000333167.1 ENSMUSG00000135939 (from geneSymbol) uc336iav.1 uc336iav.1 
ENSMUST00000333168.1 ENSMUSG00000121476 ENSMUST00000333168.1 ENSMUSG00000121476 (from geneSymbol) uc336iaw.1 uc336iaw.1 
ENSMUST00000333183.1 ENSMUSG00000135940 ENSMUST00000333183.1 ENSMUSG00000135940 (from geneSymbol) uc336ibl.1 uc336ibl.1 
ENSMUST00000333184.1 ENSMUSG00000135941 ENSMUST00000333184.1 ENSMUSG00000135941 (from geneSymbol) uc336ibm.1 uc336ibm.1 
ENSMUST00000333185.1 ENSMUSG00000135942 ENSMUST00000333185.1 ENSMUSG00000135942 (from geneSymbol) uc336ibn.1 uc336ibn.1 
ENSMUST00000333187.1 ENSMUSG00000135943 ENSMUST00000333187.1 ENSMUSG00000135943 (from geneSymbol) uc336ibp.1 uc336ibp.1 
ENSMUST00000333188.1 ENSMUSG00000135944 ENSMUST00000333188.1 ENSMUSG00000135944 (from geneSymbol) uc336ibq.1 uc336ibq.1 
ENSMUST00000333196.1 ENSMUSG00000135945 ENSMUST00000333196.1 ENSMUSG00000135945 (from geneSymbol) uc336iby.1 uc336iby.1 
ENSMUST00000333197.1 ENSMUSG00000135946 ENSMUST00000333197.1 ENSMUSG00000135946 (from geneSymbol) uc336ibz.1 uc336ibz.1 
ENSMUST00000333202.1 ENSMUSG00000135947 ENSMUST00000333202.1 ENSMUSG00000135947 (from geneSymbol) uc336ice.1 uc336ice.1 
ENSMUST00000333204.1 ENSMUSG00000135948 ENSMUST00000333204.1 ENSMUSG00000135948 (from geneSymbol) uc336icg.1 uc336icg.1 
ENSMUST00000333205.1 ENSMUSG00000135949 ENSMUST00000333205.1 ENSMUSG00000135949 (from geneSymbol) uc336ich.1 uc336ich.1 
ENSMUST00000333206.1 ENSMUSG00000135950 ENSMUST00000333206.1 ENSMUSG00000135950 (from geneSymbol) uc336ici.1 uc336ici.1 
ENSMUST00000333211.1 ENSMUSG00000135951 ENSMUST00000333211.1 ENSMUSG00000135951 (from geneSymbol) uc336icn.1 uc336icn.1 
ENSMUST00000333213.1 ENSMUSG00000135952 ENSMUST00000333213.1 ENSMUSG00000135952 (from geneSymbol) uc336icp.1 uc336icp.1 
ENSMUST00000333216.1 ENSMUSG00000135953 ENSMUST00000333216.1 ENSMUSG00000135953 (from geneSymbol) uc336ics.1 uc336ics.1 
ENSMUST00000333219.1 ENSMUSG00000135954 ENSMUST00000333219.1 ENSMUSG00000135954 (from geneSymbol) uc336icv.1 uc336icv.1 
ENSMUST00000333221.1 Gm49655 ENSMUST00000333221.1 Gm49655 (from geneSymbol) uc336icx.1 uc336icx.1 
ENSMUST00000333236.1 ENSMUSG00000135955 ENSMUST00000333236.1 ENSMUSG00000135955 (from geneSymbol) uc336idm.1 uc336idm.1 
ENSMUST00000333237.1 1700003D09Rik ENSMUST00000333237.1 1700003D09Rik (from geneSymbol) LF198846 uc336idn.1 uc336idn.1 
ENSMUST00000333238.1 ENSMUSG00000135956 ENSMUST00000333238.1 ENSMUSG00000135956 (from geneSymbol) uc336ido.1 uc336ido.1 
ENSMUST00000333242.1 ENSMUSG00000135957 ENSMUST00000333242.1 ENSMUSG00000135957 (from geneSymbol) uc336ids.1 uc336ids.1 
ENSMUST00000333244.1 ENSMUSG00000135958 ENSMUST00000333244.1 ENSMUSG00000135958 (from geneSymbol) uc336idu.1 uc336idu.1 
ENSMUST00000333245.1 ENSMUSG00000135959 ENSMUST00000333245.1 ENSMUSG00000135959 (from geneSymbol) uc336idv.1 uc336idv.1 
ENSMUST00000333250.1 ENSMUSG00000135960 ENSMUST00000333250.1 ENSMUSG00000135960 (from geneSymbol) uc336iea.1 uc336iea.1 
ENSMUST00000333256.1 ENSMUSG00000135961 ENSMUST00000333256.1 ENSMUSG00000135961 (from geneSymbol) uc336ieg.1 uc336ieg.1 
ENSMUST00000333257.1 ENSMUSG00000135962 ENSMUST00000333257.1 ENSMUSG00000135962 (from geneSymbol) uc336ieh.1 uc336ieh.1 
ENSMUST00000333270.1 ENSMUSG00000135963 ENSMUST00000333270.1 ENSMUSG00000135963 (from geneSymbol) uc336ieu.1 uc336ieu.1 
ENSMUST00000333272.1 Gm12426 ENSMUST00000333272.1 Gm12426 (from geneSymbol) uc336iew.1 uc336iew.1 
ENSMUST00000333277.1 ENSMUSG00000135964 ENSMUST00000333277.1 ENSMUSG00000135964 (from geneSymbol) uc336ifb.1 uc336ifb.1 
ENSMUST00000333280.1 ENSMUSG00000135965 ENSMUST00000333280.1 ENSMUSG00000135965 (from geneSymbol) uc336ife.1 uc336ife.1 
ENSMUST00000333285.1 ENSMUSG00000135966 ENSMUST00000333285.1 ENSMUSG00000135966 (from geneSymbol) uc336ifj.1 uc336ifj.1 
ENSMUST00000333289.1 A930006A01Rik ENSMUST00000333289.1 A930006A01Rik (from geneSymbol) uc336ifn.1 uc336ifn.1 
ENSMUST00000333290.1 ENSMUSG00000135967 ENSMUST00000333290.1 ENSMUSG00000135967 (from geneSymbol) uc336ifo.1 uc336ifo.1 
ENSMUST00000333291.1 ENSMUSG00000135968 ENSMUST00000333291.1 ENSMUSG00000135968 (from geneSymbol) uc336ifp.1 uc336ifp.1 
ENSMUST00000333292.1 ENSMUSG00000135969 ENSMUST00000333292.1 ENSMUSG00000135969 (from geneSymbol) uc336ifq.1 uc336ifq.1 
ENSMUST00000333293.1 ENSMUSG00000135970 ENSMUST00000333293.1 ENSMUSG00000135970 (from geneSymbol) uc336ifr.1 uc336ifr.1 
ENSMUST00000333294.1 ENSMUSG00000135971 ENSMUST00000333294.1 ENSMUSG00000135971 (from geneSymbol) uc336ifs.1 uc336ifs.1 
ENSMUST00000333298.1 ENSMUSG00000135972 ENSMUST00000333298.1 ENSMUSG00000135972 (from geneSymbol) uc336ifw.1 uc336ifw.1 
ENSMUST00000333302.1 ENSMUSG00000135973 ENSMUST00000333302.1 ENSMUSG00000135973 (from geneSymbol) uc336iga.1 uc336iga.1 
ENSMUST00000333303.1 ENSMUSG00000135974 ENSMUST00000333303.1 ENSMUSG00000135974 (from geneSymbol) uc336igb.1 uc336igb.1 
ENSMUST00000333332.1 ENSMUSG00000135975 ENSMUST00000333332.1 ENSMUSG00000135975 (from geneSymbol) uc336ihe.1 uc336ihe.1 
ENSMUST00000333333.1 ENSMUSG00000135976 ENSMUST00000333333.1 ENSMUSG00000135976 (from geneSymbol) uc336ihf.1 uc336ihf.1 
ENSMUST00000333334.1 ENSMUSG00000135977 ENSMUST00000333334.1 ENSMUSG00000135977 (from geneSymbol) uc336ihg.1 uc336ihg.1 
ENSMUST00000333335.1 ENSMUSG00000135978 ENSMUST00000333335.1 ENSMUSG00000135978 (from geneSymbol) uc336ihh.1 uc336ihh.1 
ENSMUST00000333340.1 ENSMUSG00000135979 ENSMUST00000333340.1 ENSMUSG00000135979 (from geneSymbol) uc336ihm.1 uc336ihm.1 
ENSMUST00000333346.1 Gm6712 ENSMUST00000333346.1 Gm6712 (from geneSymbol) AK164331 uc336ihs.1 uc336ihs.1 
ENSMUST00000333349.1 ENSMUSG00000135980 ENSMUST00000333349.1 ENSMUSG00000135980 (from geneSymbol) uc336ihv.1 uc336ihv.1 
ENSMUST00000333353.1 ENSMUSG00000135981 ENSMUST00000333353.1 ENSMUSG00000135981 (from geneSymbol) uc336ihz.1 uc336ihz.1 
ENSMUST00000333364.1 ENSMUSG00000135982 ENSMUST00000333364.1 ENSMUSG00000135982 (from geneSymbol) uc336iik.1 uc336iik.1 
ENSMUST00000333369.1 ENSMUSG00000135983 ENSMUST00000333369.1 ENSMUSG00000135983 (from geneSymbol) uc336iip.1 uc336iip.1 
ENSMUST00000333372.1 ENSMUSG00000135984 ENSMUST00000333372.1 ENSMUSG00000135984 (from geneSymbol) uc336iis.1 uc336iis.1 
ENSMUST00000333373.1 ENSMUSG00000135985 ENSMUST00000333373.1 ENSMUSG00000135985 (from geneSymbol) uc336iit.1 uc336iit.1 
ENSMUST00000333374.1 ENSMUSG00000135986 ENSMUST00000333374.1 ENSMUSG00000135986 (from geneSymbol) uc336iiu.1 uc336iiu.1 
ENSMUST00000333375.1 Gm44515 ENSMUST00000333375.1 Gm44515 (from geneSymbol) uc336iiv.1 uc336iiv.1 
ENSMUST00000333377.1 ENSMUSG00000135988 ENSMUST00000333377.1 ENSMUSG00000135988 (from geneSymbol) uc336iiw.1 uc336iiw.1 
ENSMUST00000333380.1 ENSMUSG00000135989 ENSMUST00000333380.1 ENSMUSG00000135989 (from geneSymbol) uc336iiz.1 uc336iiz.1 
ENSMUST00000333381.1 Gm43349 ENSMUST00000333381.1 Gm43349 (from geneSymbol) uc336ija.1 uc336ija.1 
ENSMUST00000333386.1 ENSMUSG00000135990 ENSMUST00000333386.1 ENSMUSG00000135990 (from geneSymbol) uc336ijf.1 uc336ijf.1 
ENSMUST00000333388.1 ENSMUSG00000135991 ENSMUST00000333388.1 ENSMUSG00000135991 (from geneSymbol) uc336ijh.1 uc336ijh.1 
ENSMUST00000333389.1 ENSMUSG00000135992 ENSMUST00000333389.1 ENSMUSG00000135992 (from geneSymbol) uc336iji.1 uc336iji.1 
ENSMUST00000333395.1 ENSMUSG00000135993 ENSMUST00000333395.1 ENSMUSG00000135993 (from geneSymbol) uc336ijo.1 uc336ijo.1 
ENSMUST00000333396.1 ENSMUSG00000135994 ENSMUST00000333396.1 ENSMUSG00000135994 (from geneSymbol) uc336ijp.1 uc336ijp.1 
ENSMUST00000333401.1 ENSMUSG00000135995 ENSMUST00000333401.1 ENSMUSG00000135995 (from geneSymbol) uc336iju.1 uc336iju.1 
ENSMUST00000333402.1 ENSMUSG00000135996 ENSMUST00000333402.1 ENSMUSG00000135996 (from geneSymbol) uc336ijv.1 uc336ijv.1 
ENSMUST00000333403.1 ENSMUSG00000135997 ENSMUST00000333403.1 ENSMUSG00000135997 (from geneSymbol) uc336ijw.1 uc336ijw.1 
ENSMUST00000333404.1 Gm36551 ENSMUST00000333404.1 Gm36551 (from geneSymbol) AK036462 uc336ijx.1 uc336ijx.1 
ENSMUST00000333415.1 ENSMUSG00000135998 ENSMUST00000333415.1 ENSMUSG00000135998 (from geneSymbol) uc336iki.1 uc336iki.1 
ENSMUST00000333416.1 ENSMUSG00000135999 ENSMUST00000333416.1 ENSMUSG00000135999 (from geneSymbol) uc336ikj.1 uc336ikj.1 
ENSMUST00000333417.1 ENSMUSG00000136000 ENSMUST00000333417.1 ENSMUSG00000136000 (from geneSymbol) uc336ikk.1 uc336ikk.1 
ENSMUST00000333418.1 ENSMUSG00000136001 ENSMUST00000333418.1 ENSMUSG00000136001 (from geneSymbol) uc336ikl.1 uc336ikl.1 
ENSMUST00000333419.1 Gm33049 ENSMUST00000333419.1 Gm33049 (from geneSymbol) uc336ikm.1 uc336ikm.1 
ENSMUST00000333426.1 ENSMUSG00000136002 ENSMUST00000333426.1 ENSMUSG00000136002 (from geneSymbol) uc336ikt.1 uc336ikt.1 
ENSMUST00000333427.1 ENSMUSG00000136003 ENSMUST00000333427.1 ENSMUSG00000136003 (from geneSymbol) uc336iku.1 uc336iku.1 
ENSMUST00000333428.1 ENSMUSG00000136004 ENSMUST00000333428.1 ENSMUSG00000136004 (from geneSymbol) uc336ikv.1 uc336ikv.1 
ENSMUST00000333429.1 ENSMUSG00000136005 ENSMUST00000333429.1 ENSMUSG00000136005 (from geneSymbol) uc336ikw.1 uc336ikw.1 
ENSMUST00000333430.1 Gm36920 ENSMUST00000333430.1 Gm36920 (from geneSymbol) uc336ikx.1 uc336ikx.1 
ENSMUST00000333443.1 ENSMUSG00000136006 ENSMUST00000333443.1 ENSMUSG00000136006 (from geneSymbol) uc336ilk.1 uc336ilk.1 
ENSMUST00000333444.1 ENSMUSG00000121729 ENSMUST00000333444.1 ENSMUSG00000121729 (from geneSymbol) uc336ill.1 uc336ill.1 
ENSMUST00000333447.1 ENSMUSG00000136008 ENSMUST00000333447.1 ENSMUSG00000136008 (from geneSymbol) uc336iln.1 uc336iln.1 
ENSMUST00000333451.1 ENSMUSG00000136009 ENSMUST00000333451.1 ENSMUSG00000136009 (from geneSymbol) uc336ilr.1 uc336ilr.1 
ENSMUST00000333452.1 ENSMUSG00000136010 ENSMUST00000333452.1 ENSMUSG00000136010 (from geneSymbol) AK013808 uc336ils.1 uc336ils.1 
ENSMUST00000333454.1 Gm31235 ENSMUST00000333454.1 Gm31235 (from geneSymbol) uc336ilt.1 uc336ilt.1 
ENSMUST00000333476.1 ENSMUSG00000136012 ENSMUST00000333476.1 ENSMUSG00000136012 (from geneSymbol) uc336imp.1 uc336imp.1 
ENSMUST00000333477.1 ENSMUSG00000136013 ENSMUST00000333477.1 ENSMUSG00000136013 (from geneSymbol) uc336imq.1 uc336imq.1 
ENSMUST00000333478.1 ENSMUSG00000136014 ENSMUST00000333478.1 ENSMUSG00000136014 (from geneSymbol) uc336imr.1 uc336imr.1 
ENSMUST00000333479.1 ENSMUSG00000136015 ENSMUST00000333479.1 ENSMUSG00000136015 (from geneSymbol) uc336ims.1 uc336ims.1 
ENSMUST00000333480.1 ENSMUSG00000136016 ENSMUST00000333480.1 ENSMUSG00000136016 (from geneSymbol) uc336imt.1 uc336imt.1 
ENSMUST00000333489.1 ENSMUSG00000136017 ENSMUST00000333489.1 ENSMUSG00000136017 (from geneSymbol) uc336inc.1 uc336inc.1 
ENSMUST00000333490.1 ENSMUSG00000136018 ENSMUST00000333490.1 ENSMUSG00000136018 (from geneSymbol) uc336ind.1 uc336ind.1 
ENSMUST00000333494.1 ENSMUSG00000136021 ENSMUST00000333494.1 ENSMUSG00000136021 (from geneSymbol) uc336ine.1 uc336ine.1 
ENSMUST00000333495.1 ENSMUSG00000136022 ENSMUST00000333495.1 ENSMUSG00000136022 (from geneSymbol) uc336inf.1 uc336inf.1 
ENSMUST00000333498.1 ENSMUSG00000136023 ENSMUST00000333498.1 ENSMUSG00000136023 (from geneSymbol) uc336ini.1 uc336ini.1 
ENSMUST00000333499.1 ENSMUSG00000136024 ENSMUST00000333499.1 ENSMUSG00000136024 (from geneSymbol) uc336inj.1 uc336inj.1 
ENSMUST00000333501.1 Gm20467 ENSMUST00000333501.1 Gm20467 (from geneSymbol) uc336inl.1 uc336inl.1 
ENSMUST00000333502.1 ENSMUSG00000136025 ENSMUST00000333502.1 ENSMUSG00000136025 (from geneSymbol) uc336inm.1 uc336inm.1 
ENSMUST00000333503.1 ENSMUSG00000136026 ENSMUST00000333503.1 ENSMUSG00000136026 (from geneSymbol) uc336inn.1 uc336inn.1 
ENSMUST00000333505.1 ENSMUSG00000136027 ENSMUST00000333505.1 ENSMUSG00000136027 (from geneSymbol) uc336inp.1 uc336inp.1 
ENSMUST00000333506.1 Tvp23bos ENSMUST00000333506.1 Tvp23bos (from geneSymbol) AK043365 uc336inq.1 uc336inq.1 
ENSMUST00000333509.1 ENSMUSG00000136028 ENSMUST00000333509.1 ENSMUSG00000136028 (from geneSymbol) uc336int.1 uc336int.1 
ENSMUST00000333510.1 ENSMUSG00000136029 ENSMUST00000333510.1 ENSMUSG00000136029 (from geneSymbol) uc336inu.1 uc336inu.1 
ENSMUST00000333513.1 ENSMUSG00000136030 ENSMUST00000333513.1 ENSMUSG00000136030 (from geneSymbol) uc336inx.1 uc336inx.1 
ENSMUST00000333518.1 ENSMUSG00000136031 ENSMUST00000333518.1 ENSMUSG00000136031 (from geneSymbol) uc336ioc.1 uc336ioc.1 
ENSMUST00000333524.1 Gm56644 ENSMUST00000333524.1 Gm56644 (from geneSymbol) uc336ioi.1 uc336ioi.1 
ENSMUST00000333536.1 Mark1-ps2 ENSMUST00000333536.1 Mark1-ps2 (from geneSymbol) uc336iou.1 uc336iou.1 
ENSMUST00000333583.1 Gm1968 ENSMUST00000333583.1 Gm1968 (from geneSymbol) AK165338 uc336iqp.1 uc336iqp.1 
ENSMUST00000333666.1 ENSMUSG00000136033 ENSMUST00000333666.1 ENSMUSG00000136033 (from geneSymbol) uc336itu.1 uc336itu.1 
ENSMUST00000333668.1 ENSMUSG00000136034 ENSMUST00000333668.1 ENSMUSG00000136034 (from geneSymbol) uc336itw.1 uc336itw.1 
ENSMUST00000333676.1 3300002P13Rik ENSMUST00000333676.1 3300002P13Rik (from geneSymbol) AK014378 uc336iue.1 uc336iue.1 
ENSMUST00000333687.1 ENSMUSG00000136035 ENSMUST00000333687.1 ENSMUSG00000136035 (from geneSymbol) uc336iup.1 uc336iup.1 
ENSMUST00000333688.1 Mipepos ENSMUST00000333688.1 Mipepos (from geneSymbol) uc336iuq.1 uc336iuq.1 
ENSMUST00000333705.1 ENSMUSG00000136036 ENSMUST00000333705.1 ENSMUSG00000136036 (from geneSymbol) KY467495 uc336ivh.1 uc336ivh.1 
ENSMUST00000333726.1 ENSMUSG00000136037 ENSMUST00000333726.1 ENSMUSG00000136037 (from geneSymbol) uc336iwc.1 uc336iwc.1 
ENSMUST00000333727.1 Gm33111 ENSMUST00000333727.1 Gm33111 (from geneSymbol) KY467633 uc336iwd.1 uc336iwd.1 
ENSMUST00000333742.1 ENSMUSG00000136038 ENSMUST00000333742.1 ENSMUSG00000136038 (from geneSymbol) uc336iws.1 uc336iws.1 
ENSMUST00000333744.1 1700025M24Rik ENSMUST00000333744.1 1700025M24Rik (from geneSymbol) AK006359 uc336iwu.1 uc336iwu.1 
ENSMUST00000333767.1 ENSMUSG00000136039 ENSMUST00000333767.1 ENSMUSG00000136039 (from geneSymbol) uc336ixr.1 uc336ixr.1 
ENSMUST00000333768.1 ENSMUSG00000136040 ENSMUST00000333768.1 ENSMUSG00000136040 (from geneSymbol) uc336ixs.1 uc336ixs.1 
ENSMUST00000333776.1 ENSMUSG00000136041 ENSMUST00000333776.1 ENSMUSG00000136041 (from geneSymbol) uc336iya.1 uc336iya.1 
ENSMUST00000333777.1 1700047G07Rik ENSMUST00000333777.1 1700047G07Rik (from geneSymbol) AK006709 uc336iyb.1 uc336iyb.1 
ENSMUST00000333781.1 ENSMUSG00000136042 ENSMUST00000333781.1 ENSMUSG00000136042 (from geneSymbol) uc336iyf.1 uc336iyf.1 
ENSMUST00000333783.1 ENSMUSG00000136043 ENSMUST00000333783.1 ENSMUSG00000136043 (from geneSymbol) uc336iyh.1 uc336iyh.1 
ENSMUST00000333786.1 ENSMUSG00000136044 ENSMUST00000333786.1 ENSMUSG00000136044 (from geneSymbol) uc336iyk.1 uc336iyk.1 
ENSMUST00000333787.1 ENSMUSG00000136045 ENSMUST00000333787.1 ENSMUSG00000136045 (from geneSymbol) uc336iyl.1 uc336iyl.1 
ENSMUST00000333790.1 ENSMUSG00000136046 ENSMUST00000333790.1 ENSMUSG00000136046 (from geneSymbol) uc336iyo.1 uc336iyo.1 
ENSMUST00000333791.1 ENSMUSG00000136047 ENSMUST00000333791.1 ENSMUSG00000136047 (from geneSymbol) uc336iyp.1 uc336iyp.1 
ENSMUST00000333794.1 ENSMUSG00000136048 ENSMUST00000333794.1 ENSMUSG00000136048 (from geneSymbol) uc336iys.1 uc336iys.1 
ENSMUST00000333798.1 ENSMUSG00000136049 ENSMUST00000333798.1 ENSMUSG00000136049 (from geneSymbol) uc336iyw.1 uc336iyw.1 
ENSMUST00000333812.1 ENSMUSG00000136050 ENSMUST00000333812.1 ENSMUSG00000136050 (from geneSymbol) uc336izk.1 uc336izk.1 
ENSMUST00000333813.1 ENSMUSG00000136051 ENSMUST00000333813.1 ENSMUSG00000136051 (from geneSymbol) uc336izl.1 uc336izl.1 
ENSMUST00000333816.1 ENSMUSG00000136052 ENSMUST00000333816.1 ENSMUSG00000136052 (from geneSymbol) uc336izo.1 uc336izo.1 
ENSMUST00000333819.1 ENSMUSG00000136053 ENSMUST00000333819.1 ENSMUSG00000136053 (from geneSymbol) uc336izr.1 uc336izr.1 
ENSMUST00000333823.1 ENSMUSG00000136054 ENSMUST00000333823.1 ENSMUSG00000136054 (from geneSymbol) uc336izv.1 uc336izv.1 
ENSMUST00000333824.1 ENSMUSG00000136055 ENSMUST00000333824.1 ENSMUSG00000136055 (from geneSymbol) uc336izw.1 uc336izw.1 
ENSMUST00000333836.1 ENSMUSG00000136056 ENSMUST00000333836.1 ENSMUSG00000136056 (from geneSymbol) uc336jai.1 uc336jai.1 
ENSMUST00000333846.1 ENSMUSG00000136058 ENSMUST00000333846.1 ENSMUSG00000136058 (from geneSymbol) uc336jar.1 uc336jar.1 
ENSMUST00000333848.1 ENSMUSG00000136059 ENSMUST00000333848.1 ENSMUSG00000136059 (from geneSymbol) uc336jat.1 uc336jat.1 
ENSMUST00000333849.1 ENSMUSG00000136060 ENSMUST00000333849.1 ENSMUSG00000136060 (from geneSymbol) uc336jau.1 uc336jau.1 
ENSMUST00000333866.1 ENSMUSG00000136061 ENSMUST00000333866.1 ENSMUSG00000136061 (from geneSymbol) uc336jbl.1 uc336jbl.1 
ENSMUST00000333867.1 Gm39858 ENSMUST00000333867.1 Gm39858 (from geneSymbol) uc336jbm.1 uc336jbm.1 
ENSMUST00000333871.1 ENSMUSG00000136063 ENSMUST00000333871.1 ENSMUSG00000136063 (from geneSymbol) uc336jbo.1 uc336jbo.1 
ENSMUST00000333874.1 Gm36598 ENSMUST00000333874.1 predicted gene, 36598 (from RefSeq NR_166701.1) NR_166701 uc336jbq.1 uc336jbq.1 
ENSMUST00000333876.1 ENSMUSG00000136066 ENSMUST00000333876.1 ENSMUSG00000136066 (from geneSymbol) uc336jbs.1 uc336jbs.1 
ENSMUST00000333880.1 ENSMUSG00000136067 ENSMUST00000333880.1 ENSMUSG00000136067 (from geneSymbol) uc336jbw.1 uc336jbw.1 
ENSMUST00000333881.1 ENSMUSG00000136068 ENSMUST00000333881.1 ENSMUSG00000136068 (from geneSymbol) uc336jbx.1 uc336jbx.1 
ENSMUST00000333883.1 ENSMUSG00000136069 ENSMUST00000333883.1 ENSMUSG00000136069 (from geneSymbol) uc336jbz.1 uc336jbz.1 
ENSMUST00000333884.1 ENSMUSG00000136070 ENSMUST00000333884.1 ENSMUSG00000136070 (from geneSymbol) uc336jca.1 uc336jca.1 
ENSMUST00000333885.1 ENSMUSG00000136071 ENSMUST00000333885.1 ENSMUSG00000136071 (from geneSymbol) uc336jcb.1 uc336jcb.1 
ENSMUST00000333886.1 ENSMUSG00000136072 ENSMUST00000333886.1 ENSMUSG00000136072 (from geneSymbol) uc336jcc.1 uc336jcc.1 
ENSMUST00000333887.1 ENSMUSG00000136073 ENSMUST00000333887.1 ENSMUSG00000136073 (from geneSymbol) uc336jcd.1 uc336jcd.1 
ENSMUST00000333888.1 ENSMUSG00000136074 ENSMUST00000333888.1 ENSMUSG00000136074 (from geneSymbol) uc336jce.1 uc336jce.1 
ENSMUST00000333890.1 ENSMUSG00000136075 ENSMUST00000333890.1 ENSMUSG00000136075 (from geneSymbol) uc336jcg.1 uc336jcg.1 
ENSMUST00000333892.1 Gm34574 ENSMUST00000333892.1 Gm34574 (from geneSymbol) uc336jci.1 uc336jci.1 
ENSMUST00000333904.1 ENSMUSG00000136076 ENSMUST00000333904.1 ENSMUSG00000136076 (from geneSymbol) uc336jcu.1 uc336jcu.1 
ENSMUST00000333905.1 ENSMUSG00000136077 ENSMUST00000333905.1 ENSMUSG00000136077 (from geneSymbol) uc336jcv.1 uc336jcv.1 
ENSMUST00000333908.1 ENSMUSG00000136079 ENSMUST00000333908.1 ENSMUSG00000136079 (from geneSymbol) uc336jcx.1 uc336jcx.1 
ENSMUST00000333909.1 ENSMUSG00000136080 ENSMUST00000333909.1 ENSMUSG00000136080 (from geneSymbol) uc336jcy.1 uc336jcy.1 
ENSMUST00000333910.1 Gm34411 ENSMUST00000333910.1 Gm34411 (from geneSymbol) uc336jcz.1 uc336jcz.1 
ENSMUST00000333959.1 ENSMUSG00000136081 ENSMUST00000333959.1 ENSMUSG00000136081 (from geneSymbol) uc336jew.1 uc336jew.1 
ENSMUST00000333960.1 ENSMUSG00000136082 ENSMUST00000333960.1 ENSMUSG00000136082 (from geneSymbol) uc336jex.1 uc336jex.1 
ENSMUST00000333963.1 ENSMUSG00000136083 ENSMUST00000333963.1 ENSMUSG00000136083 (from geneSymbol) uc336jfa.1 uc336jfa.1 
ENSMUST00000333966.1 ENSMUSG00000136084 ENSMUST00000333966.1 ENSMUSG00000136084 (from geneSymbol) uc336jfd.1 uc336jfd.1 
ENSMUST00000333968.1 ENSMUSG00000136085 ENSMUST00000333968.1 ENSMUSG00000136085 (from geneSymbol) uc336jff.1 uc336jff.1 
ENSMUST00000333977.1 Gm44714 ENSMUST00000333977.1 Gm44714 (from geneSymbol) uc336jfo.1 uc336jfo.1 
ENSMUST00000333979.1 ENSMUSG00000136086 ENSMUST00000333979.1 ENSMUSG00000136086 (from geneSymbol) uc336jfq.1 uc336jfq.1 
ENSMUST00000333980.1 ENSMUSG00000136087 ENSMUST00000333980.1 ENSMUSG00000136087 (from geneSymbol) uc336jfr.1 uc336jfr.1 
ENSMUST00000333981.1 ENSMUSG00000136088 ENSMUST00000333981.1 ENSMUSG00000136088 (from geneSymbol) uc336jfs.1 uc336jfs.1 
ENSMUST00000333983.1 ENSMUSG00000136089 ENSMUST00000333983.1 ENSMUSG00000136089 (from geneSymbol) uc336jfu.1 uc336jfu.1 
ENSMUST00000333993.1 Gm36670 ENSMUST00000333993.1 Gm36670 (from geneSymbol) uc336jge.1 uc336jge.1 
ENSMUST00000334020.1 ENSMUSG00000136090 ENSMUST00000334020.1 ENSMUSG00000136090 (from geneSymbol) uc336jhf.1 uc336jhf.1 
ENSMUST00000334022.1 ENSMUSG00000136091 ENSMUST00000334022.1 ENSMUSG00000136091 (from geneSymbol) uc336jhh.1 uc336jhh.1 
ENSMUST00000334024.1 ENSMUSG00000121643 ENSMUST00000334024.1 ENSMUSG00000121643 (from geneSymbol) uc336jhj.1 uc336jhj.1 
ENSMUST00000334035.1 Gm35113 ENSMUST00000334035.1 Gm35113 (from geneSymbol) uc336jhu.1 uc336jhu.1 
ENSMUST00000334039.1 ENSMUSG00000136092 ENSMUST00000334039.1 ENSMUSG00000136092 (from geneSymbol) uc336jhy.1 uc336jhy.1 
ENSMUST00000334040.1 ENSMUSG00000136093 ENSMUST00000334040.1 ENSMUSG00000136093 (from geneSymbol) uc336jhz.1 uc336jhz.1 
ENSMUST00000334048.1 ENSMUSG00000136094 ENSMUST00000334048.1 ENSMUSG00000136094 (from geneSymbol) uc336jih.1 uc336jih.1 
ENSMUST00000334050.1 ENSMUSG00000136095 ENSMUST00000334050.1 ENSMUSG00000136095 (from geneSymbol) uc336jij.1 uc336jij.1 
ENSMUST00000334052.1 Gm43101 ENSMUST00000334052.1 Gm43101 (from geneSymbol) uc336jil.1 uc336jil.1 
ENSMUST00000334056.1 ENSMUSG00000136096 ENSMUST00000334056.1 ENSMUSG00000136096 (from geneSymbol) uc336jip.1 uc336jip.1 
ENSMUST00000334057.1 ENSMUSG00000136097 ENSMUST00000334057.1 ENSMUSG00000136097 (from geneSymbol) uc336jiq.1 uc336jiq.1 
ENSMUST00000334058.1 ENSMUSG00000136098 ENSMUST00000334058.1 ENSMUSG00000136098 (from geneSymbol) uc336jir.1 uc336jir.1 
ENSMUST00000334059.1 ENSMUSG00000136099 ENSMUST00000334059.1 ENSMUSG00000136099 (from geneSymbol) uc336jis.1 uc336jis.1 
ENSMUST00000334061.1 ENSMUSG00000136100 ENSMUST00000334061.1 ENSMUSG00000136100 (from geneSymbol) uc336jiu.1 uc336jiu.1 
ENSMUST00000334063.1 ENSMUSG00000136101 ENSMUST00000334063.1 ENSMUSG00000136101 (from geneSymbol) uc336jiw.1 uc336jiw.1 
ENSMUST00000334150.1 ENSMUSG00000136102 ENSMUST00000334150.1 ENSMUSG00000136102 (from geneSymbol) uc336jmf.1 uc336jmf.1 
ENSMUST00000334153.1 ENSMUSG00000136103 ENSMUST00000334153.1 ENSMUSG00000136103 (from geneSymbol) AK041503 uc336jmi.1 uc336jmi.1 
ENSMUST00000334155.1 Gm34096 ENSMUST00000334155.1 Gm34096 (from geneSymbol) uc336jmk.1 uc336jmk.1 
ENSMUST00000334172.1 ENSMUSG00000136104 ENSMUST00000334172.1 ENSMUSG00000136104 (from geneSymbol) uc336jnb.1 uc336jnb.1 
ENSMUST00000334178.1 ENSMUSG00000136105 ENSMUST00000334178.1 ENSMUSG00000136105 (from geneSymbol) uc336jnh.1 uc336jnh.1 
ENSMUST00000334186.1 ENSMUSG00000136106 ENSMUST00000334186.1 ENSMUSG00000136106 (from geneSymbol) uc336jnp.1 uc336jnp.1 
ENSMUST00000334192.1 ENSMUSG00000136107 ENSMUST00000334192.1 ENSMUSG00000136107 (from geneSymbol) uc336jnv.1 uc336jnv.1 
ENSMUST00000334195.1 ENSMUSG00000136108 ENSMUST00000334195.1 ENSMUSG00000136108 (from geneSymbol) uc336jny.1 uc336jny.1 
ENSMUST00000334198.1 ENSMUSG00000136109 ENSMUST00000334198.1 ENSMUSG00000136109 (from geneSymbol) uc336job.1 uc336job.1 
ENSMUST00000334201.1 ENSMUSG00000136110 ENSMUST00000334201.1 ENSMUSG00000136110 (from geneSymbol) uc336joe.1 uc336joe.1 
ENSMUST00000334205.1 ENSMUSG00000136111 ENSMUST00000334205.1 ENSMUSG00000136111 (from geneSymbol) uc336joi.1 uc336joi.1 
ENSMUST00000334206.1 Gm39289 ENSMUST00000334206.1 Gm39289 (from geneSymbol) uc336joj.1 uc336joj.1 
ENSMUST00000334216.1 ENSMUSG00000136113 ENSMUST00000334216.1 ENSMUSG00000136113 (from geneSymbol) uc336jot.1 uc336jot.1 
ENSMUST00000334219.1 ENSMUSG00000136114 ENSMUST00000334219.1 ENSMUSG00000136114 (from geneSymbol) uc336jow.1 uc336jow.1 
ENSMUST00000334228.1 ENSMUSG00000136116 ENSMUST00000334228.1 ENSMUSG00000136116 (from geneSymbol) uc336joz.1 uc336joz.1 
ENSMUST00000334230.1 ENSMUSG00000136117 ENSMUST00000334230.1 ENSMUSG00000136117 (from geneSymbol) uc336jpb.1 uc336jpb.1 
ENSMUST00000334232.1 Gm56974 ENSMUST00000334232.1 Gm56974 (from geneSymbol) uc336jpd.1 uc336jpd.1 
ENSMUST00000334237.1 ENSMUSG00000136118 ENSMUST00000334237.1 ENSMUSG00000136118 (from geneSymbol) uc336jpi.1 uc336jpi.1 
ENSMUST00000334238.1 ENSMUSG00000136119 ENSMUST00000334238.1 ENSMUSG00000136119 (from geneSymbol) LF205019 uc336jpj.1 uc336jpj.1 
ENSMUST00000334239.1 ENSMUSG00000136120 ENSMUST00000334239.1 ENSMUSG00000136120 (from geneSymbol) uc336jpk.1 uc336jpk.1 
ENSMUST00000334249.1 ENSMUSG00000136121 ENSMUST00000334249.1 ENSMUSG00000136121 (from geneSymbol) uc336jpu.1 uc336jpu.1 
ENSMUST00000334250.1 ENSMUSG00000136122 ENSMUST00000334250.1 ENSMUSG00000136122 (from geneSymbol) uc336jpv.1 uc336jpv.1 
ENSMUST00000334251.1 ENSMUSG00000136123 ENSMUST00000334251.1 ENSMUSG00000136123 (from geneSymbol) uc336jpw.1 uc336jpw.1 
ENSMUST00000334252.1 ENSMUSG00000136124 ENSMUST00000334252.1 ENSMUSG00000136124 (from geneSymbol) uc336jpx.1 uc336jpx.1 
ENSMUST00000334261.1 ENSMUSG00000136125 ENSMUST00000334261.1 ENSMUSG00000136125 (from geneSymbol) uc336jqg.1 uc336jqg.1 
ENSMUST00000334268.1 ENSMUSG00000136126 ENSMUST00000334268.1 ENSMUSG00000136126 (from geneSymbol) uc336jqn.1 uc336jqn.1 
ENSMUST00000334269.1 ENSMUSG00000136127 ENSMUST00000334269.1 ENSMUSG00000136127 (from geneSymbol) uc336jqo.1 uc336jqo.1 
ENSMUST00000334284.1 ENSMUSG00000136128 ENSMUST00000334284.1 ENSMUSG00000136128 (from geneSymbol) uc336jrd.1 uc336jrd.1 
ENSMUST00000334303.1 ENSMUSG00000136129 ENSMUST00000334303.1 ENSMUSG00000136129 (from geneSymbol) uc336jrv.1 uc336jrv.1 
ENSMUST00000334304.1 ENSMUSG00000136130 ENSMUST00000334304.1 ENSMUSG00000136130 (from geneSymbol) uc336jrw.1 uc336jrw.1 
ENSMUST00000334305.1 ENSMUSG00000136131 ENSMUST00000334305.1 ENSMUSG00000136131 (from geneSymbol) uc336jrx.1 uc336jrx.1 
ENSMUST00000334308.1 ENSMUSG00000136132 ENSMUST00000334308.1 ENSMUSG00000136132 (from geneSymbol) uc336jsa.1 uc336jsa.1 
ENSMUST00000334309.1 ENSMUSG00000136133 ENSMUST00000334309.1 ENSMUSG00000136133 (from geneSymbol) uc336jsb.1 uc336jsb.1 
ENSMUST00000334311.1 ENSMUSG00000136134 ENSMUST00000334311.1 ENSMUSG00000136134 (from geneSymbol) uc336jsd.1 uc336jsd.1 
ENSMUST00000334315.1 ENSMUSG00000136135 ENSMUST00000334315.1 ENSMUSG00000136135 (from geneSymbol) uc336jsh.1 uc336jsh.1 
ENSMUST00000334317.1 ENSMUSG00000136136 ENSMUST00000334317.1 ENSMUSG00000136136 (from geneSymbol) uc336jsj.1 uc336jsj.1 
ENSMUST00000334319.1 ENSMUSG00000136137 ENSMUST00000334319.1 ENSMUSG00000136137 (from geneSymbol) uc336jsl.1 uc336jsl.1 
ENSMUST00000334321.1 ENSMUSG00000136138 ENSMUST00000334321.1 ENSMUSG00000136138 (from geneSymbol) uc336jsn.1 uc336jsn.1 
ENSMUST00000334322.1 ENSMUSG00000136139 ENSMUST00000334322.1 ENSMUSG00000136139 (from geneSymbol) uc336jso.1 uc336jso.1 
ENSMUST00000334327.1 ENSMUSG00000136140 ENSMUST00000334327.1 ENSMUSG00000136140 (from geneSymbol) uc336jst.1 uc336jst.1 
ENSMUST00000334329.1 ENSMUSG00000136141 ENSMUST00000334329.1 ENSMUSG00000136141 (from geneSymbol) uc336jsv.1 uc336jsv.1 
ENSMUST00000334336.1 ENSMUSG00000136142 ENSMUST00000334336.1 ENSMUSG00000136142 (from geneSymbol) uc336jtc.1 uc336jtc.1 
ENSMUST00000334338.1 ENSMUSG00000136143 ENSMUST00000334338.1 ENSMUSG00000136143 (from geneSymbol) uc336jte.1 uc336jte.1 
ENSMUST00000334339.1 ENSMUSG00000136144 ENSMUST00000334339.1 ENSMUSG00000136144 (from geneSymbol) uc336jtf.1 uc336jtf.1 
ENSMUST00000334340.1 ENSMUSG00000136145 ENSMUST00000334340.1 ENSMUSG00000136145 (from geneSymbol) uc336jtg.1 uc336jtg.1 
ENSMUST00000334341.1 ENSMUSG00000136146 ENSMUST00000334341.1 ENSMUSG00000136146 (from geneSymbol) uc336jth.1 uc336jth.1 
ENSMUST00000334343.1 ENSMUSG00000136147 ENSMUST00000334343.1 ENSMUSG00000136147 (from geneSymbol) uc336jtj.1 uc336jtj.1 
ENSMUST00000334350.1 ENSMUSG00000136148 ENSMUST00000334350.1 ENSMUSG00000136148 (from geneSymbol) uc336jtq.1 uc336jtq.1 
ENSMUST00000334360.1 ENSMUSG00000136149 ENSMUST00000334360.1 ENSMUSG00000136149 (from geneSymbol) uc336jua.1 uc336jua.1 
ENSMUST00000334362.1 ENSMUSG00000136150 ENSMUST00000334362.1 ENSMUSG00000136150 (from geneSymbol) uc336juc.1 uc336juc.1 
ENSMUST00000334363.1 1700122C19Rik ENSMUST00000334363.1 1700122C19Rik (from geneSymbol) AK018976 uc336jud.1 uc336jud.1 
ENSMUST00000334387.1 ENSMUSG00000136151 ENSMUST00000334387.1 ENSMUSG00000136151 (from geneSymbol) uc336jvb.1 uc336jvb.1 
ENSMUST00000334389.1 ENSMUSG00000136153 ENSMUST00000334389.1 ENSMUSG00000136153 (from geneSymbol) uc336jvc.1 uc336jvc.1 
ENSMUST00000334390.1 ENSMUSG00000136154 ENSMUST00000334390.1 ENSMUSG00000136154 (from geneSymbol) uc336jvd.1 uc336jvd.1 
ENSMUST00000334394.1 ENSMUSG00000136155 ENSMUST00000334394.1 ENSMUSG00000136155 (from geneSymbol) uc336jvh.1 uc336jvh.1 
ENSMUST00000334395.1 ENSMUSG00000136156 ENSMUST00000334395.1 ENSMUSG00000136156 (from geneSymbol) uc336jvi.1 uc336jvi.1 
ENSMUST00000334396.1 ENSMUSG00000136157 ENSMUST00000334396.1 ENSMUSG00000136157 (from geneSymbol) uc336jvj.1 uc336jvj.1 
ENSMUST00000334398.1 ENSMUSG00000136158 ENSMUST00000334398.1 ENSMUSG00000136158 (from geneSymbol) uc336jvl.1 uc336jvl.1 
ENSMUST00000334423.1 ENSMUSG00000136159 ENSMUST00000334423.1 ENSMUSG00000136159 (from geneSymbol) uc336jwk.1 uc336jwk.1 
ENSMUST00000334426.1 ENSMUSG00000136160 ENSMUST00000334426.1 ENSMUSG00000136160 (from geneSymbol) uc336jwn.1 uc336jwn.1 
ENSMUST00000334432.1 ENSMUSG00000136161 ENSMUST00000334432.1 ENSMUSG00000136161 (from geneSymbol) uc336jwt.1 uc336jwt.1 
ENSMUST00000334437.1 Gm14487 ENSMUST00000334437.1 Gm14487 (from geneSymbol) uc336jwy.1 uc336jwy.1 
ENSMUST00000334461.1 ENSMUSG00000136162 ENSMUST00000334461.1 ENSMUSG00000136162 (from geneSymbol) uc336jxw.1 uc336jxw.1 
ENSMUST00000334465.1 ENSMUSG00000136163 ENSMUST00000334465.1 ENSMUSG00000136163 (from geneSymbol) uc336jya.1 uc336jya.1 
ENSMUST00000334466.1 ENSMUSG00000136164 ENSMUST00000334466.1 ENSMUSG00000136164 (from geneSymbol) uc336jyb.1 uc336jyb.1 
ENSMUST00000334467.1 ENSMUSG00000136165 ENSMUST00000334467.1 ENSMUSG00000136165 (from geneSymbol) uc336jyc.1 uc336jyc.1 
ENSMUST00000334468.1 ENSMUSG00000136166 ENSMUST00000334468.1 ENSMUSG00000136166 (from geneSymbol) uc336jyd.1 uc336jyd.1 
ENSMUST00000334469.1 ENSMUSG00000136167 ENSMUST00000334469.1 ENSMUSG00000136167 (from geneSymbol) uc336jye.1 uc336jye.1 
ENSMUST00000334470.1 Gm14174 ENSMUST00000334470.1 Gm14174 (from geneSymbol) AK032272 uc336jyf.1 uc336jyf.1 
ENSMUST00000334473.1 Gm19956 ENSMUST00000334473.1 Gm19956 (from geneSymbol) uc336jyi.1 uc336jyi.1 
ENSMUST00000334483.1 ENSMUSG00000136168 ENSMUST00000334483.1 ENSMUSG00000136168 (from geneSymbol) uc336jys.1 uc336jys.1 
ENSMUST00000334484.1 9130209A04Rik ENSMUST00000334484.1 9130209A04Rik (from geneSymbol) AK020276 uc336jyt.1 uc336jyt.1 
ENSMUST00000334495.1 ENSMUSG00000136169 ENSMUST00000334495.1 ENSMUSG00000136169 (from geneSymbol) uc336jze.1 uc336jze.1 
ENSMUST00000334496.1 ENSMUSG00000136170 ENSMUST00000334496.1 ENSMUSG00000136170 (from geneSymbol) uc336jzf.1 uc336jzf.1 
ENSMUST00000334505.1 ENSMUSG00000136171 ENSMUST00000334505.1 ENSMUSG00000136171 (from geneSymbol) uc336jzo.1 uc336jzo.1 
ENSMUST00000334518.1 Gm33981 ENSMUST00000334518.1 Gm33981 (from geneSymbol) uc336kab.1 uc336kab.1 
ENSMUST00000334529.1 ENSMUSG00000136172 ENSMUST00000334529.1 ENSMUSG00000136172 (from geneSymbol) uc336kam.1 uc336kam.1 
ENSMUST00000334534.1 ENSMUSG00000136173 ENSMUST00000334534.1 ENSMUSG00000136173 (from geneSymbol) uc336kar.1 uc336kar.1 
ENSMUST00000334540.1 ENSMUSG00000136174 ENSMUST00000334540.1 ENSMUSG00000136174 (from geneSymbol) uc336kax.1 uc336kax.1 
ENSMUST00000334543.1 ENSMUSG00000121307 ENSMUST00000334543.1 ENSMUSG00000121307 (from geneSymbol) BC083083 uc336kba.1 uc336kba.1 
ENSMUST00000334545.1 Gm47448 ENSMUST00000334545.1 Gm47448 (from geneSymbol) uc336kbc.1 uc336kbc.1 
ENSMUST00000334554.1 ENSMUSG00000136175 ENSMUST00000334554.1 ENSMUSG00000136175 (from geneSymbol) uc336kbl.1 uc336kbl.1 
ENSMUST00000334557.1 ENSMUSG00000136176 ENSMUST00000334557.1 ENSMUSG00000136176 (from geneSymbol) uc336kbo.1 uc336kbo.1 
ENSMUST00000334573.1 ENSMUSG00000136177 ENSMUST00000334573.1 ENSMUSG00000136177 (from geneSymbol) uc336kce.1 uc336kce.1 
ENSMUST00000334599.1 ENSMUSG00000136178 ENSMUST00000334599.1 ENSMUSG00000136178 (from geneSymbol) uc336kde.1 uc336kde.1 
ENSMUST00000334614.1 ENSMUSG00000136179 ENSMUST00000334614.1 ENSMUSG00000136179 (from geneSymbol) uc336kdt.1 uc336kdt.1 
ENSMUST00000334615.1 4930557K07Rik ENSMUST00000334615.1 4930557K07Rik (from geneSymbol) AK019772 uc336kdu.1 uc336kdu.1 
ENSMUST00000334630.1 ENSMUSG00000136180 ENSMUST00000334630.1 ENSMUSG00000136180 (from geneSymbol) uc336kej.1 uc336kej.1 
ENSMUST00000334635.1 Bcas1os2 ENSMUST00000334635.1 Bcas1os2 (from geneSymbol) AK006663 uc336keo.1 uc336keo.1 
ENSMUST00000334636.1 ENSMUSG00000136181 ENSMUST00000334636.1 ENSMUSG00000136181 (from geneSymbol) uc336kep.1 uc336kep.1 
ENSMUST00000334637.1 ENSMUSG00000136182 ENSMUST00000334637.1 ENSMUSG00000136182 (from geneSymbol) AK084781 uc336keq.1 uc336keq.1 
ENSMUST00000334641.1 ENSMUSG00000136183 ENSMUST00000334641.1 ENSMUSG00000136183 (from geneSymbol) uc336keu.1 uc336keu.1 
ENSMUST00000334650.1 ENSMUSG00000136184 ENSMUST00000334650.1 ENSMUSG00000136184 (from geneSymbol) uc336kfd.1 uc336kfd.1 
ENSMUST00000334652.1 ENSMUSG00000136185 ENSMUST00000334652.1 ENSMUSG00000136185 (from geneSymbol) uc336kff.1 uc336kff.1 
ENSMUST00000334654.1 Gm35615 ENSMUST00000334654.1 Gm35615 (from geneSymbol) uc336kfh.1 uc336kfh.1 
ENSMUST00000334659.1 ENSMUSG00000136186 ENSMUST00000334659.1 ENSMUSG00000136186 (from geneSymbol) uc336kfm.1 uc336kfm.1 
ENSMUST00000334661.1 ENSMUSG00000136187 ENSMUST00000334661.1 ENSMUSG00000136187 (from geneSymbol) uc336kfo.1 uc336kfo.1 
ENSMUST00000334671.1 Gm32342 ENSMUST00000334671.1 Gm32342 (from geneSymbol) uc336kfy.1 uc336kfy.1 
ENSMUST00000334686.1 ENSMUSG00000136188 ENSMUST00000334686.1 ENSMUSG00000136188 (from geneSymbol) uc336kgn.1 uc336kgn.1 
ENSMUST00000334687.1 ENSMUSG00000136189 ENSMUST00000334687.1 ENSMUSG00000136189 (from geneSymbol) uc336kgo.1 uc336kgo.1 
ENSMUST00000334688.1 ENSMUSG00000136190 ENSMUST00000334688.1 ENSMUSG00000136190 (from geneSymbol) uc336kgp.1 uc336kgp.1 
ENSMUST00000334690.1 Gm21060 ENSMUST00000334690.1 Gm21060 (from geneSymbol) uc336kgr.1 uc336kgr.1 
ENSMUST00000334707.1 ENSMUSG00000136191 ENSMUST00000334707.1 ENSMUSG00000136191 (from geneSymbol) uc336khi.1 uc336khi.1 
ENSMUST00000334708.1 ENSMUSG00000136192 ENSMUST00000334708.1 ENSMUSG00000136192 (from geneSymbol) uc336khj.1 uc336khj.1 
ENSMUST00000334709.1 ENSMUSG00000136193 ENSMUST00000334709.1 ENSMUSG00000136193 (from geneSymbol) uc336khk.1 uc336khk.1 
ENSMUST00000334710.1 ENSMUSG00000136194 ENSMUST00000334710.1 ENSMUSG00000136194 (from geneSymbol) uc336khl.1 uc336khl.1 
ENSMUST00000334711.1 ENSMUSG00000136195 ENSMUST00000334711.1 ENSMUSG00000136195 (from geneSymbol) uc336khm.1 uc336khm.1 
ENSMUST00000334714.1 ENSMUSG00000136196 ENSMUST00000334714.1 ENSMUSG00000136196 (from geneSymbol) uc336khp.1 uc336khp.1 
ENSMUST00000334715.1 ENSMUSG00000136197 ENSMUST00000334715.1 ENSMUSG00000136197 (from geneSymbol) uc336khq.1 uc336khq.1 
ENSMUST00000334719.1 ENSMUSG00000136198 ENSMUST00000334719.1 ENSMUSG00000136198 (from geneSymbol) uc336khu.1 uc336khu.1 
ENSMUST00000334724.1 ENSMUSG00000136199 ENSMUST00000334724.1 ENSMUSG00000136199 (from geneSymbol) uc336khz.1 uc336khz.1 
ENSMUST00000334730.1 ENSMUSG00000136200 ENSMUST00000334730.1 ENSMUSG00000136200 (from geneSymbol) uc336kif.1 uc336kif.1 
ENSMUST00000334734.1 ENSMUSG00000136201 ENSMUST00000334734.1 ENSMUSG00000136201 (from geneSymbol) uc336kij.1 uc336kij.1 
ENSMUST00000334738.1 Gm36525 ENSMUST00000334738.1 Gm36525 (from geneSymbol) uc336kin.1 uc336kin.1 
ENSMUST00000334749.1 ENSMUSG00000136202 ENSMUST00000334749.1 ENSMUSG00000136202 (from geneSymbol) uc336kiy.1 uc336kiy.1 
ENSMUST00000334750.1 ENSMUSG00000136203 ENSMUST00000334750.1 ENSMUSG00000136203 (from geneSymbol) uc336kiz.1 uc336kiz.1 
ENSMUST00000334752.1 ENSMUSG00000136205 ENSMUST00000334752.1 ENSMUSG00000136205 (from geneSymbol) uc336kja.1 uc336kja.1 
ENSMUST00000334755.1 ENSMUSG00000136206 ENSMUST00000334755.1 ENSMUSG00000136206 (from geneSymbol) uc336kjd.1 uc336kjd.1 
ENSMUST00000334756.1 ENSMUSG00000136207 ENSMUST00000334756.1 ENSMUSG00000136207 (from geneSymbol) uc336kje.1 uc336kje.1 
ENSMUST00000334763.1 ENSMUSG00000136208 ENSMUST00000334763.1 ENSMUSG00000136208 (from geneSymbol) uc336kjl.1 uc336kjl.1 
ENSMUST00000334764.1 ENSMUSG00000136209 ENSMUST00000334764.1 ENSMUSG00000136209 (from geneSymbol) uc336kjm.1 uc336kjm.1 
ENSMUST00000334767.1 A630052C17Rik ENSMUST00000334767.1 A630052C17Rik (from geneSymbol) uc336kjp.1 uc336kjp.1 
ENSMUST00000334779.1 Gm32191 ENSMUST00000334779.1 Gm32191 (from geneSymbol) uc336kkb.1 uc336kkb.1 
ENSMUST00000334795.1 ENSMUSG00000136210 ENSMUST00000334795.1 ENSMUSG00000136210 (from geneSymbol) AK015172 uc336kkr.1 uc336kkr.1 
ENSMUST00000334796.1 ENSMUSG00000136211 ENSMUST00000334796.1 ENSMUSG00000136211 (from geneSymbol) uc336kks.1 uc336kks.1 
ENSMUST00000334801.1 ENSMUSG00000136212 ENSMUST00000334801.1 ENSMUSG00000136212 (from geneSymbol) uc336kkx.1 uc336kkx.1 
ENSMUST00000334802.1 ENSMUSG00000136213 ENSMUST00000334802.1 ENSMUSG00000136213 (from geneSymbol) uc336kky.1 uc336kky.1 
ENSMUST00000334804.1 ENSMUSG00000136214 ENSMUST00000334804.1 ENSMUSG00000136214 (from geneSymbol) uc336kla.1 uc336kla.1 
ENSMUST00000334805.1 ENSMUSG00000136215 ENSMUST00000334805.1 ENSMUSG00000136215 (from geneSymbol) uc336klb.1 uc336klb.1 
ENSMUST00000334807.1 ENSMUSG00000136216 ENSMUST00000334807.1 ENSMUSG00000136216 (from geneSymbol) uc336kld.1 uc336kld.1 
ENSMUST00000334809.1 ENSMUSG00000136217 ENSMUST00000334809.1 ENSMUSG00000136217 (from geneSymbol) uc336klf.1 uc336klf.1 
ENSMUST00000334810.1 ENSMUSG00000136218 ENSMUST00000334810.1 ENSMUSG00000136218 (from geneSymbol) uc336klg.1 uc336klg.1 
ENSMUST00000334811.1 9130227L01Rik ENSMUST00000334811.1 9130227L01Rik (from geneSymbol) AK079812 uc336klh.1 uc336klh.1 
ENSMUST00000334822.1 ENSMUSG00000136219 ENSMUST00000334822.1 ENSMUSG00000136219 (from geneSymbol) uc336kls.1 uc336kls.1 
ENSMUST00000334824.1 ENSMUSG00000136220 ENSMUST00000334824.1 ENSMUSG00000136220 (from geneSymbol) uc336klu.1 uc336klu.1 
ENSMUST00000334826.1 ENSMUSG00000136221 ENSMUST00000334826.1 ENSMUSG00000136221 (from geneSymbol) uc336klw.1 uc336klw.1 
ENSMUST00000334827.1 B230119M05Rik ENSMUST00000334827.1 B230119M05Rik (from geneSymbol) AK020983 uc336klx.1 uc336klx.1 
ENSMUST00000334830.1 ENSMUSG00000136222 ENSMUST00000334830.1 ENSMUSG00000136222 (from geneSymbol) uc336kma.1 uc336kma.1 
ENSMUST00000334831.1 ENSMUSG00000136223 ENSMUST00000334831.1 ENSMUSG00000136223 (from geneSymbol) uc336kmb.1 uc336kmb.1 
ENSMUST00000334833.1 ENSMUSG00000136224 ENSMUST00000334833.1 ENSMUSG00000136224 (from geneSymbol) uc336kmd.1 uc336kmd.1 
ENSMUST00000334836.1 ENSMUSG00000136225 ENSMUST00000334836.1 ENSMUSG00000136225 (from geneSymbol) BC099537 uc336kmg.1 uc336kmg.1 
ENSMUST00000334839.1 ENSMUSG00000136226 ENSMUST00000334839.1 ENSMUSG00000136226 (from geneSymbol) uc336kmj.1 uc336kmj.1 
ENSMUST00000334840.1 ENSMUSG00000136227 ENSMUST00000334840.1 ENSMUSG00000136227 (from geneSymbol) uc336kmk.1 uc336kmk.1 
ENSMUST00000334841.1 1700027F06Rik ENSMUST00000334841.1 1700027F06Rik (from geneSymbol) AK005943 uc336kml.1 uc336kml.1 
ENSMUST00000334860.1 ENSMUSG00000136228 ENSMUST00000334860.1 ENSMUSG00000136228 (from geneSymbol) uc336kne.1 uc336kne.1 
ENSMUST00000334863.1 ENSMUSG00000136229 ENSMUST00000334863.1 ENSMUSG00000136229 (from geneSymbol) uc336knh.1 uc336knh.1 
ENSMUST00000334864.1 ENSMUSG00000136230 ENSMUST00000334864.1 ENSMUSG00000136230 (from geneSymbol) uc336kni.1 uc336kni.1 
ENSMUST00000334865.1 ENSMUSG00000136231 ENSMUST00000334865.1 ENSMUSG00000136231 (from geneSymbol) uc336knj.1 uc336knj.1 
ENSMUST00000334869.1 ENSMUSG00000136232 ENSMUST00000334869.1 ENSMUSG00000136232 (from geneSymbol) AK019762 uc336knn.1 uc336knn.1 
ENSMUST00000334877.1 Gm30313 ENSMUST00000334877.1 Gm30313 (from geneSymbol) uc336knv.1 uc336knv.1 
ENSMUST00000334889.1 ENSMUSG00000136233 ENSMUST00000334889.1 ENSMUSG00000136233 (from geneSymbol) uc336koh.1 uc336koh.1 
ENSMUST00000334890.1 ENSMUSG00000136234 ENSMUST00000334890.1 ENSMUSG00000136234 (from geneSymbol) uc336koi.1 uc336koi.1 
ENSMUST00000334893.1 ENSMUSG00000136235 ENSMUST00000334893.1 ENSMUSG00000136235 (from geneSymbol) uc336kol.1 uc336kol.1 
ENSMUST00000334898.1 ENSMUSG00000136236 ENSMUST00000334898.1 ENSMUSG00000136236 (from geneSymbol) uc336koq.1 uc336koq.1 
ENSMUST00000334899.1 ENSMUSG00000136237 ENSMUST00000334899.1 ENSMUSG00000136237 (from geneSymbol) uc336kor.1 uc336kor.1 
ENSMUST00000334904.1 1700121C10Rik ENSMUST00000334904.1 RIKEN cDNA 1700121C10 gene (from RefSeq NR_190168.1) NR_190168 uc336kow.1 uc336kow.1 
ENSMUST00000334906.1 ENSMUSG00000136239 ENSMUST00000334906.1 ENSMUSG00000136239 (from geneSymbol) uc336koy.1 uc336koy.1 
ENSMUST00000334908.1 ENSMUSG00000136240 ENSMUST00000334908.1 ENSMUSG00000136240 (from geneSymbol) uc336kpa.1 uc336kpa.1 
ENSMUST00000334909.1 ENSMUSG00000136241 ENSMUST00000334909.1 ENSMUSG00000136241 (from geneSymbol) uc336kpb.1 uc336kpb.1 
ENSMUST00000334913.1 AI115009 ENSMUST00000334913.1 AI115009 (from geneSymbol) AK043786 uc336kpf.1 uc336kpf.1 
ENSMUST00000334918.1 ENSMUSG00000136242 ENSMUST00000334918.1 ENSMUSG00000136242 (from geneSymbol) uc336kpk.1 uc336kpk.1 
ENSMUST00000334919.1 ENSMUSG00000136243 ENSMUST00000334919.1 ENSMUSG00000136243 (from geneSymbol) uc336kpl.1 uc336kpl.1 
ENSMUST00000334922.1 ENSMUSG00000136244 ENSMUST00000334922.1 ENSMUSG00000136244 (from geneSymbol) uc336kpo.1 uc336kpo.1 
ENSMUST00000334923.1 ENSMUSG00000136245 ENSMUST00000334923.1 ENSMUSG00000136245 (from geneSymbol) uc336kpp.1 uc336kpp.1 
ENSMUST00000334924.1 ENSMUSG00000136246 ENSMUST00000334924.1 ENSMUSG00000136246 (from geneSymbol) uc336kpq.1 uc336kpq.1 
ENSMUST00000334925.1 ENSMUSG00000136247 ENSMUST00000334925.1 ENSMUSG00000136247 (from geneSymbol) uc336kpr.1 uc336kpr.1 
ENSMUST00000334926.1 ENSMUSG00000136248 ENSMUST00000334926.1 ENSMUSG00000136248 (from geneSymbol) uc336kps.1 uc336kps.1 
ENSMUST00000334927.1 ENSMUSG00000136249 ENSMUST00000334927.1 ENSMUSG00000136249 (from geneSymbol) uc336kpt.1 uc336kpt.1 
ENSMUST00000334928.1 ENSMUSG00000136250 ENSMUST00000334928.1 ENSMUSG00000136250 (from geneSymbol) uc336kpu.1 uc336kpu.1 
ENSMUST00000334929.1 ENSMUSG00000136251 ENSMUST00000334929.1 ENSMUSG00000136251 (from geneSymbol) uc336kpv.1 uc336kpv.1 
ENSMUST00000334933.1 ENSMUSG00000136252 ENSMUST00000334933.1 ENSMUSG00000136252 (from geneSymbol) uc336kpz.1 uc336kpz.1 
ENSMUST00000334936.1 ENSMUSG00000136253 ENSMUST00000334936.1 ENSMUSG00000136253 (from geneSymbol) uc336kqc.1 uc336kqc.1 
ENSMUST00000334939.1 ENSMUSG00000136254 ENSMUST00000334939.1 ENSMUSG00000136254 (from geneSymbol) uc336kqf.1 uc336kqf.1 
ENSMUST00000334940.1 ENSMUSG00000136255 ENSMUST00000334940.1 ENSMUSG00000136255 (from geneSymbol) uc336kqg.1 uc336kqg.1 
ENSMUST00000334943.1 ENSMUSG00000136256 ENSMUST00000334943.1 ENSMUSG00000136256 (from geneSymbol) uc336kqj.1 uc336kqj.1 
ENSMUST00000334948.1 Gm48530 ENSMUST00000334948.1 Gm48530 (from geneSymbol) uc336kqo.1 uc336kqo.1 
ENSMUST00000334955.1 ENSMUSG00000136257 ENSMUST00000334955.1 ENSMUSG00000136257 (from geneSymbol) uc336kqv.1 uc336kqv.1 
ENSMUST00000334956.1 ENSMUSG00000136258 ENSMUST00000334956.1 ENSMUSG00000136258 (from geneSymbol) uc336kqw.1 uc336kqw.1 
ENSMUST00000334962.1 4930480M12Rik ENSMUST00000334962.1 4930480M12Rik (from geneSymbol) AK015603 uc336krc.1 uc336krc.1 
ENSMUST00000334967.1 ENSMUSG00000136259 ENSMUST00000334967.1 ENSMUSG00000136259 (from geneSymbol) uc336krh.1 uc336krh.1 
ENSMUST00000334974.1 ENSMUSG00000136260 ENSMUST00000334974.1 ENSMUSG00000136260 (from geneSymbol) uc336kro.1 uc336kro.1 
ENSMUST00000334976.1 Rapgef4os1 ENSMUST00000334976.1 Rapgef4os1 (from geneSymbol) uc336krq.1 uc336krq.1 
ENSMUST00000334977.1 ENSMUSG00000136261 ENSMUST00000334977.1 ENSMUSG00000136261 (from geneSymbol) uc336krr.1 uc336krr.1 
ENSMUST00000334978.1 ENSMUSG00000136262 ENSMUST00000334978.1 ENSMUSG00000136262 (from geneSymbol) uc336krs.1 uc336krs.1 
ENSMUST00000334980.1 ENSMUSG00000136263 ENSMUST00000334980.1 ENSMUSG00000136263 (from geneSymbol) uc336kru.1 uc336kru.1 
ENSMUST00000334981.1 ENSMUSG00000136264 ENSMUST00000334981.1 ENSMUSG00000136264 (from geneSymbol) uc336krv.1 uc336krv.1 
ENSMUST00000334991.1 Gm26664 ENSMUST00000334991.1 Gm26664 (from geneSymbol) AK039409 uc336ksd.1 uc336ksd.1 
ENSMUST00000335008.1 ENSMUSG00000136265 ENSMUST00000335008.1 ENSMUSG00000136265 (from geneSymbol) uc336ksu.1 uc336ksu.1 
ENSMUST00000335012.1 Gm44006 ENSMUST00000335012.1 Gm44006 (from geneSymbol) AK006844 uc336ksy.1 uc336ksy.1 
ENSMUST00000335021.1 ENSMUSG00000136266 ENSMUST00000335021.1 ENSMUSG00000136266 (from geneSymbol) uc336kth.1 uc336kth.1 
ENSMUST00000335022.1 ENSMUSG00000136267 ENSMUST00000335022.1 ENSMUSG00000136267 (from geneSymbol) uc336kti.1 uc336kti.1 
ENSMUST00000335023.1 ENSMUSG00000136268 ENSMUST00000335023.1 ENSMUSG00000136268 (from geneSymbol) uc336ktj.1 uc336ktj.1 
ENSMUST00000335024.1 ENSMUSG00000136269 ENSMUST00000335024.1 ENSMUSG00000136269 (from geneSymbol) uc336ktk.1 uc336ktk.1 
ENSMUST00000335031.1 ENSMUSG00000136270 ENSMUST00000335031.1 ENSMUSG00000136270 (from geneSymbol) uc336ktr.1 uc336ktr.1 
ENSMUST00000335036.1 ENSMUSG00000136271 ENSMUST00000335036.1 ENSMUSG00000136271 (from geneSymbol) uc336ktw.1 uc336ktw.1 
ENSMUST00000335037.1 Gm26877 ENSMUST00000335037.1 Gm26877 (from geneSymbol) AK132865 uc336ktx.1 uc336ktx.1 
ENSMUST00000335040.1 Gm57048 ENSMUST00000335040.1 Gm57048 (from geneSymbol) uc336ktz.1 uc336ktz.1 
ENSMUST00000335042.1 Gm5092 ENSMUST00000335042.1 Gm5092 (from geneSymbol) AK030245 uc336kub.1 uc336kub.1 
ENSMUST00000335054.1 ENSMUSG00000136272 ENSMUST00000335054.1 ENSMUSG00000136272 (from geneSymbol) uc336kun.1 uc336kun.1 
ENSMUST00000335060.1 ENSMUSG00000136273 ENSMUST00000335060.1 ENSMUSG00000136273 (from geneSymbol) AK134158 uc336kut.1 uc336kut.1 
ENSMUST00000335061.1 ENSMUSG00000136274 ENSMUST00000335061.1 ENSMUSG00000136274 (from geneSymbol) uc336kuu.1 uc336kuu.1 
ENSMUST00000335064.1 ENSMUSG00000136276 ENSMUST00000335064.1 ENSMUSG00000136276 (from geneSymbol) uc336kuv.1 uc336kuv.1 
ENSMUST00000335066.1 ENSMUSG00000136277 ENSMUST00000335066.1 ENSMUSG00000136277 (from geneSymbol) uc336kux.1 uc336kux.1 
ENSMUST00000335067.1 ENSMUSG00000136278 ENSMUST00000335067.1 ENSMUSG00000136278 (from geneSymbol) uc336kuy.1 uc336kuy.1 
ENSMUST00000335074.1 ENSMUSG00000136279 ENSMUST00000335074.1 ENSMUSG00000136279 (from geneSymbol) uc336kvf.1 uc336kvf.1 
ENSMUST00000335077.1 ENSMUSG00000136280 ENSMUST00000335077.1 ENSMUSG00000136280 (from geneSymbol) uc336kvi.1 uc336kvi.1 
ENSMUST00000335083.1 ENSMUSG00000136281 ENSMUST00000335083.1 ENSMUSG00000136281 (from geneSymbol) uc336kvo.1 uc336kvo.1 
ENSMUST00000335084.1 4930505K14Rik ENSMUST00000335084.1 4930505K14Rik (from geneSymbol) AK019669 uc336kvp.1 uc336kvp.1 
ENSMUST00000335107.1 ENSMUSG00000136282 ENSMUST00000335107.1 ENSMUSG00000136282 (from geneSymbol) uc336kwm.1 uc336kwm.1 
ENSMUST00000335108.1 ENSMUSG00000136283 ENSMUST00000335108.1 ENSMUSG00000136283 (from geneSymbol) uc336kwn.1 uc336kwn.1 
ENSMUST00000335109.1 ENSMUSG00000136284 ENSMUST00000335109.1 ENSMUSG00000136284 (from geneSymbol) uc336kwo.1 uc336kwo.1 
ENSMUST00000335110.1 ENSMUSG00000136285 ENSMUST00000335110.1 ENSMUSG00000136285 (from geneSymbol) uc336kwp.1 uc336kwp.1 
ENSMUST00000335112.1 ENSMUSG00000136286 ENSMUST00000335112.1 ENSMUSG00000136286 (from geneSymbol) uc336kwr.1 uc336kwr.1 
ENSMUST00000335117.1 ENSMUSG00000136287 ENSMUST00000335117.1 ENSMUSG00000136287 (from geneSymbol) uc336kww.1 uc336kww.1 
ENSMUST00000335118.1 ENSMUSG00000136288 ENSMUST00000335118.1 ENSMUSG00000136288 (from geneSymbol) uc336kwx.1 uc336kwx.1 
ENSMUST00000335128.1 ENSMUSG00000136289 ENSMUST00000335128.1 ENSMUSG00000136289 (from geneSymbol) uc336kxh.1 uc336kxh.1 
ENSMUST00000335129.1 ENSMUSG00000136290 ENSMUST00000335129.1 ENSMUSG00000136290 (from geneSymbol) uc336kxi.1 uc336kxi.1 
ENSMUST00000335133.1 ENSMUSG00000136291 ENSMUST00000335133.1 ENSMUSG00000136291 (from geneSymbol) uc336kxm.1 uc336kxm.1 
ENSMUST00000335134.1 ENSMUSG00000136292 ENSMUST00000335134.1 predicted gene 12627 (from RefSeq NR_172467.1) NR_172467 uc336kxn.1 uc336kxn.1 
ENSMUST00000335136.1 Gm40653 ENSMUST00000335136.1 Gm40653 (from geneSymbol) uc336kxp.1 uc336kxp.1 
ENSMUST00000335143.1 ENSMUSG00000136293 ENSMUST00000335143.1 ENSMUSG00000136293 (from geneSymbol) uc336kxw.1 uc336kxw.1 
ENSMUST00000335163.1 ENSMUSG00000136294 ENSMUST00000335163.1 ENSMUSG00000136294 (from geneSymbol) AK078963 uc336kyq.1 uc336kyq.1 
ENSMUST00000335166.1 ENSMUSG00000136295 ENSMUST00000335166.1 ENSMUSG00000136295 (from geneSymbol) uc336kyt.1 uc336kyt.1 
ENSMUST00000335167.1 ENSMUSG00000136296 ENSMUST00000335167.1 ENSMUSG00000136296 (from geneSymbol) uc336kyu.1 uc336kyu.1 
ENSMUST00000335168.1 ENSMUSG00000136297 ENSMUST00000335168.1 ENSMUSG00000136297 (from geneSymbol) uc336kyv.1 uc336kyv.1 
ENSMUST00000335174.1 ENSMUSG00000136298 ENSMUST00000335174.1 ENSMUSG00000136298 (from geneSymbol) uc336kzb.1 uc336kzb.1 
ENSMUST00000335179.1 ENSMUSG00000136299 ENSMUST00000335179.1 ENSMUSG00000136299 (from geneSymbol) AK076958 uc336kzg.1 uc336kzg.1 
ENSMUST00000335181.1 ENSMUSG00000136300 ENSMUST00000335181.1 ENSMUSG00000136300 (from geneSymbol) uc336kzi.1 uc336kzi.1 
ENSMUST00000335192.1 ENSMUSG00000136301 ENSMUST00000335192.1 ENSMUSG00000136301 (from geneSymbol) uc336kzt.1 uc336kzt.1 
ENSMUST00000335196.1 ENSMUSG00000136302 ENSMUST00000335196.1 ENSMUSG00000136302 (from geneSymbol) uc336kzx.1 uc336kzx.1 
ENSMUST00000335197.1 ENSMUSG00000136303 ENSMUST00000335197.1 ENSMUSG00000136303 (from geneSymbol) uc336kzy.1 uc336kzy.1 
ENSMUST00000335207.1 ENSMUSG00000136304 ENSMUST00000335207.1 ENSMUSG00000136304 (from geneSymbol) uc336lai.1 uc336lai.1 
ENSMUST00000335209.1 Gm56846 ENSMUST00000335209.1 Gm56846 (from geneSymbol) uc336lak.1 uc336lak.1 
ENSMUST00000335215.1 ENSMUSG00000136306 ENSMUST00000335215.1 ENSMUSG00000136306 (from geneSymbol) uc336laq.1 uc336laq.1 
ENSMUST00000335216.1 ENSMUSG00000136307 ENSMUST00000335216.1 ENSMUSG00000136307 (from geneSymbol) uc336lar.1 uc336lar.1 
ENSMUST00000335218.1 ENSMUSG00000136309 ENSMUST00000335218.1 ENSMUSG00000136309 (from geneSymbol) uc336las.1 uc336las.1 
ENSMUST00000335219.1 ENSMUSG00000136310 ENSMUST00000335219.1 ENSMUSG00000136310 (from geneSymbol) uc336lat.1 uc336lat.1 
ENSMUST00000335220.1 ENSMUSG00000136311 ENSMUST00000335220.1 ENSMUSG00000136311 (from geneSymbol) uc336lau.1 uc336lau.1 
ENSMUST00000335222.1 ENSMUSG00000136312 ENSMUST00000335222.1 ENSMUSG00000136312 (from geneSymbol) uc336law.1 uc336law.1 
ENSMUST00000335223.1 ENSMUSG00000136313 ENSMUST00000335223.1 ENSMUSG00000136313 (from geneSymbol) uc336lax.1 uc336lax.1 
ENSMUST00000335226.1 ENSMUSG00000136314 ENSMUST00000335226.1 ENSMUSG00000136314 (from geneSymbol) uc336lba.1 uc336lba.1 
ENSMUST00000335227.1 ENSMUSG00000136315 ENSMUST00000335227.1 ENSMUSG00000136315 (from geneSymbol) uc336lbb.1 uc336lbb.1 
ENSMUST00000335229.1 ENSMUSG00000136316 ENSMUST00000335229.1 ENSMUSG00000136316 (from geneSymbol) uc336lbd.1 uc336lbd.1 
ENSMUST00000335231.1 ENSMUSG00000136317 ENSMUST00000335231.1 ENSMUSG00000136317 (from geneSymbol) uc336lbf.1 uc336lbf.1 
ENSMUST00000335241.1 ENSMUSG00000136319 ENSMUST00000335241.1 ENSMUSG00000136319 (from geneSymbol) uc336lbn.1 uc336lbn.1 
ENSMUST00000335242.1 ENSMUSG00000136320 ENSMUST00000335242.1 ENSMUSG00000136320 (from geneSymbol) uc336lbo.1 uc336lbo.1 
ENSMUST00000335245.1 ENSMUSG00000136321 ENSMUST00000335245.1 ENSMUSG00000136321 (from geneSymbol) uc336lbr.1 uc336lbr.1 
ENSMUST00000335246.1 ENSMUSG00000136322 ENSMUST00000335246.1 ENSMUSG00000136322 (from geneSymbol) uc336lbs.1 uc336lbs.1 
ENSMUST00000335247.1 ENSMUSG00000136323 ENSMUST00000335247.1 ENSMUSG00000136323 (from geneSymbol) uc336lbt.1 uc336lbt.1 
ENSMUST00000335252.1 ENSMUSG00000136324 ENSMUST00000335252.1 ENSMUSG00000136324 (from geneSymbol) uc336lby.1 uc336lby.1 
ENSMUST00000335253.1 ENSMUSG00000136325 ENSMUST00000335253.1 ENSMUSG00000136325 (from geneSymbol) uc336lbz.1 uc336lbz.1 
ENSMUST00000335254.1 ENSMUSG00000136326 ENSMUST00000335254.1 ENSMUSG00000136326 (from geneSymbol) uc336lca.1 uc336lca.1 
ENSMUST00000335255.1 ENSMUSG00000136327 ENSMUST00000335255.1 ENSMUSG00000136327 (from geneSymbol) uc336lcb.1 uc336lcb.1 
ENSMUST00000335256.1 Gm43574 ENSMUST00000335256.1 Gm43574 (from geneSymbol) uc336lcc.1 uc336lcc.1 
ENSMUST00000335268.1 ENSMUSG00000136328 ENSMUST00000335268.1 ENSMUSG00000136328 (from geneSymbol) uc336lco.1 uc336lco.1 
ENSMUST00000335272.1 ENSMUSG00000136329 ENSMUST00000335272.1 ENSMUSG00000136329 (from geneSymbol) AK087670 uc336lcs.1 uc336lcs.1 
ENSMUST00000335277.1 ENSMUSG00000136330 ENSMUST00000335277.1 ENSMUSG00000136330 (from geneSymbol) AK016249 uc336lcx.1 uc336lcx.1 
ENSMUST00000335278.1 ENSMUSG00000136331 ENSMUST00000335278.1 ENSMUSG00000136331 (from geneSymbol) uc336lcy.1 uc336lcy.1 
ENSMUST00000335281.1 ENSMUSG00000136332 ENSMUST00000335281.1 ENSMUSG00000136332 (from geneSymbol) uc336ldb.1 uc336ldb.1 
ENSMUST00000335284.1 ENSMUSG00000136333 ENSMUST00000335284.1 ENSMUSG00000136333 (from geneSymbol) uc336lde.1 uc336lde.1 
ENSMUST00000335285.1 ENSMUSG00000136334 ENSMUST00000335285.1 ENSMUSG00000136334 (from geneSymbol) uc336ldf.1 uc336ldf.1 
ENSMUST00000335287.1 ENSMUSG00000136335 ENSMUST00000335287.1 ENSMUSG00000136335 (from geneSymbol) uc336ldh.1 uc336ldh.1 
ENSMUST00000335288.1 ENSMUSG00000136336 ENSMUST00000335288.1 ENSMUSG00000136336 (from geneSymbol) uc336ldi.1 uc336ldi.1 
ENSMUST00000335291.1 ENSMUSG00000136337 ENSMUST00000335291.1 ENSMUSG00000136337 (from geneSymbol) uc336ldl.1 uc336ldl.1 
ENSMUST00000335294.1 ENSMUSG00000136338 ENSMUST00000335294.1 ENSMUSG00000136338 (from geneSymbol) uc336ldo.1 uc336ldo.1 
ENSMUST00000335296.1 ENSMUSG00000136339 ENSMUST00000335296.1 ENSMUSG00000136339 (from geneSymbol) uc336ldq.1 uc336ldq.1 
ENSMUST00000335299.1 9630014M24Rik ENSMUST00000335299.1 9630014M24Rik (from geneSymbol) AK035890 uc336ldt.1 uc336ldt.1 
ENSMUST00000335306.1 Gm48923 ENSMUST00000335306.1 Gm48923 (from geneSymbol) uc336lea.1 uc336lea.1 
ENSMUST00000335312.1 ENSMUSG00000136340 ENSMUST00000335312.1 ENSMUSG00000136340 (from geneSymbol) uc336leg.1 uc336leg.1 
ENSMUST00000335313.1 ENSMUSG00000136341 ENSMUST00000335313.1 ENSMUSG00000136341 (from geneSymbol) uc336leh.1 uc336leh.1 
ENSMUST00000335314.1 ENSMUSG00000136342 ENSMUST00000335314.1 ENSMUSG00000136342 (from geneSymbol) uc336lei.1 uc336lei.1 
ENSMUST00000335315.1 ENSMUSG00000136343 ENSMUST00000335315.1 ENSMUSG00000136343 (from geneSymbol) uc336lej.1 uc336lej.1 
ENSMUST00000335317.1 1700025N21Rik ENSMUST00000335317.1 1700025N21Rik (from geneSymbol) AK006360 uc336lel.1 uc336lel.1 
ENSMUST00000335319.1 ENSMUSG00000136344 ENSMUST00000335319.1 ENSMUSG00000136344 (from geneSymbol) uc336len.1 uc336len.1 
ENSMUST00000335326.1 ENSMUSG00000136345 ENSMUST00000335326.1 ENSMUSG00000136345 (from geneSymbol) uc336leu.1 uc336leu.1 
ENSMUST00000335329.1 ENSMUSG00000136346 ENSMUST00000335329.1 ENSMUSG00000136346 (from geneSymbol) uc336lex.1 uc336lex.1 
ENSMUST00000335330.1 ENSMUSG00000136347 ENSMUST00000335330.1 ENSMUSG00000136347 (from geneSymbol) uc336ley.1 uc336ley.1 
ENSMUST00000335336.1 ENSMUSG00000136348 ENSMUST00000335336.1 ENSMUSG00000136348 (from geneSymbol) uc336lfe.1 uc336lfe.1 
ENSMUST00000335339.1 Gm35190 ENSMUST00000335339.1 Gm35190 (from geneSymbol) uc336lfh.1 uc336lfh.1 
ENSMUST00000335350.1 ENSMUSG00000136349 ENSMUST00000335350.1 ENSMUSG00000136349 (from geneSymbol) uc336lfs.1 uc336lfs.1 
ENSMUST00000335361.1 ENSMUSG00000136350 ENSMUST00000335361.1 ENSMUSG00000136350 (from geneSymbol) AK006494 uc336lgd.1 uc336lgd.1 
ENSMUST00000335362.1 ENSMUSG00000136351 ENSMUST00000335362.1 ENSMUSG00000136351 (from geneSymbol) uc336lge.1 uc336lge.1 
ENSMUST00000335364.1 ENSMUSG00000136353 ENSMUST00000335364.1 ENSMUSG00000136353 (from geneSymbol) uc336lgf.1 uc336lgf.1 
ENSMUST00000335365.1 ENSMUSG00000136354 ENSMUST00000335365.1 ENSMUSG00000136354 (from geneSymbol) uc336lgg.1 uc336lgg.1 
ENSMUST00000335366.1 5033417F24Rik ENSMUST00000335366.1 RIKEN cDNA 5033417F24 gene, transcript variant 1 (from RefSeq NR_138577.1) NR_138577 uc336lgh.1 uc336lgh.1 
ENSMUST00000335369.1 ENSMUSG00000136355 ENSMUST00000335369.1 ENSMUSG00000136355 (from geneSymbol) uc336lgk.1 uc336lgk.1 
ENSMUST00000335370.1 ENSMUSG00000136356 ENSMUST00000335370.1 ENSMUSG00000136356 (from geneSymbol) uc336lgl.1 uc336lgl.1 
ENSMUST00000335371.1 ENSMUSG00000136357 ENSMUST00000335371.1 ENSMUSG00000136357 (from geneSymbol) uc336lgm.1 uc336lgm.1 
ENSMUST00000335373.1 ENSMUSG00000136358 ENSMUST00000335373.1 ENSMUSG00000136358 (from geneSymbol) uc336lgo.1 uc336lgo.1 
ENSMUST00000335376.1 ENSMUSG00000136359 ENSMUST00000335376.1 ENSMUSG00000136359 (from geneSymbol) uc336lgr.1 uc336lgr.1 
ENSMUST00000335380.1 ENSMUSG00000136360 ENSMUST00000335380.1 ENSMUSG00000136360 (from geneSymbol) uc336lgv.1 uc336lgv.1 
ENSMUST00000335381.1 ENSMUSG00000136361 ENSMUST00000335381.1 ENSMUSG00000136361 (from geneSymbol) uc336lgw.1 uc336lgw.1 
ENSMUST00000335383.1 ENSMUSG00000136362 ENSMUST00000335383.1 ENSMUSG00000136362 (from geneSymbol) uc336lgy.1 uc336lgy.1 
ENSMUST00000335384.1 ENSMUSG00000136363 ENSMUST00000335384.1 ENSMUSG00000136363 (from geneSymbol) uc336lgz.1 uc336lgz.1 
ENSMUST00000335385.1 ENSMUSG00000136364 ENSMUST00000335385.1 ENSMUSG00000136364 (from geneSymbol) uc336lha.1 uc336lha.1 
ENSMUST00000335387.1 ENSMUSG00000136365 ENSMUST00000335387.1 ENSMUSG00000136365 (from geneSymbol) uc336lhb.1 uc336lhb.1 
ENSMUST00000335389.1 ENSMUSG00000136366 ENSMUST00000335389.1 ENSMUSG00000136366 (from geneSymbol) uc336lhd.1 uc336lhd.1 
ENSMUST00000335390.1 ENSMUSG00000136367 ENSMUST00000335390.1 ENSMUSG00000136367 (from geneSymbol) uc336lhe.1 uc336lhe.1 
ENSMUST00000335391.1 ENSMUSG00000136368 ENSMUST00000335391.1 ENSMUSG00000136368 (from geneSymbol) uc336lhf.1 uc336lhf.1 
ENSMUST00000335398.1 ENSMUSG00000136369 ENSMUST00000335398.1 ENSMUSG00000136369 (from geneSymbol) uc336lhm.1 uc336lhm.1 
ENSMUST00000335409.1 Gm30476 ENSMUST00000335409.1 Gm30476 (from geneSymbol) uc336lhx.1 uc336lhx.1 
ENSMUST00000335433.1 ENSMUSG00000136370 ENSMUST00000335433.1 ENSMUSG00000136370 (from geneSymbol) uc336liv.1 uc336liv.1 
ENSMUST00000335441.1 ENSMUSG00000136372 ENSMUST00000335441.1 ENSMUSG00000136372 (from geneSymbol) uc336ljc.1 uc336ljc.1 
ENSMUST00000335449.1 ENSMUSG00000136373 ENSMUST00000335449.1 ENSMUSG00000136373 (from geneSymbol) uc336ljk.1 uc336ljk.1 
ENSMUST00000335451.1 ENSMUSG00000136374 ENSMUST00000335451.1 ENSMUSG00000136374 (from geneSymbol) uc336ljm.1 uc336ljm.1 
ENSMUST00000335452.1 ENSMUSG00000136375 ENSMUST00000335452.1 ENSMUSG00000136375 (from geneSymbol) uc336ljn.1 uc336ljn.1 
ENSMUST00000335453.1 ENSMUSG00000136376 ENSMUST00000335453.1 ENSMUSG00000136376 (from geneSymbol) uc336ljo.1 uc336ljo.1 
ENSMUST00000335455.1 ENSMUSG00000136377 ENSMUST00000335455.1 ENSMUSG00000136377 (from geneSymbol) uc336ljq.1 uc336ljq.1 
ENSMUST00000335456.1 ENSMUSG00000136378 ENSMUST00000335456.1 ENSMUSG00000136378 (from geneSymbol) uc336ljr.1 uc336ljr.1 
ENSMUST00000335459.1 ENSMUSG00000136379 ENSMUST00000335459.1 ENSMUSG00000136379 (from geneSymbol) uc336lju.1 uc336lju.1 
ENSMUST00000335460.1 ENSMUSG00000136380 ENSMUST00000335460.1 ENSMUSG00000136380 (from geneSymbol) uc336ljv.1 uc336ljv.1 
ENSMUST00000335462.1 ENSMUSG00000136381 ENSMUST00000335462.1 ENSMUSG00000136381 (from geneSymbol) uc336ljx.1 uc336ljx.1 
ENSMUST00000335464.1 ENSMUSG00000136382 ENSMUST00000335464.1 ENSMUSG00000136382 (from geneSymbol) uc336ljz.1 uc336ljz.1 
ENSMUST00000335466.1 ENSMUSG00000136383 ENSMUST00000335466.1 ENSMUSG00000136383 (from geneSymbol) uc336lkb.1 uc336lkb.1 
ENSMUST00000335476.1 ENSMUSG00000136384 ENSMUST00000335476.1 ENSMUSG00000136384 (from geneSymbol) uc336lkl.1 uc336lkl.1 
ENSMUST00000335478.1 Gm41517 ENSMUST00000335478.1 Gm41517 (from geneSymbol) uc336lkn.1 uc336lkn.1 
ENSMUST00000335487.1 ENSMUSG00000136385 ENSMUST00000335487.1 ENSMUSG00000136385 (from geneSymbol) uc336lkw.1 uc336lkw.1 
ENSMUST00000335490.1 Gm39213 ENSMUST00000335490.1 Gm39213 (from geneSymbol) uc336lkz.1 uc336lkz.1 
ENSMUST00000335507.1 ENSMUSG00000136386 ENSMUST00000335507.1 ENSMUSG00000136386 (from geneSymbol) uc336llq.1 uc336llq.1 
ENSMUST00000335508.1 ENSMUSG00000136387 ENSMUST00000335508.1 ENSMUSG00000136387 (from geneSymbol) uc336llr.1 uc336llr.1 
ENSMUST00000335509.1 ENSMUSG00000136388 ENSMUST00000335509.1 ENSMUSG00000136388 (from geneSymbol) uc336lls.1 uc336lls.1 
ENSMUST00000335517.1 ENSMUSG00000136389 ENSMUST00000335517.1 ENSMUSG00000136389 (from geneSymbol) uc336lma.1 uc336lma.1 
ENSMUST00000335518.1 ENSMUSG00000136390 ENSMUST00000335518.1 ENSMUSG00000136390 (from geneSymbol) uc336lmb.1 uc336lmb.1 
ENSMUST00000335519.1 ENSMUSG00000136391 ENSMUST00000335519.1 ENSMUSG00000136391 (from geneSymbol) uc336lmc.1 uc336lmc.1 
ENSMUST00000335522.1 ENSMUSG00000136392 ENSMUST00000335522.1 ENSMUSG00000136392 (from geneSymbol) uc336lmf.1 uc336lmf.1 
ENSMUST00000335523.1 4930455F16Rik ENSMUST00000335523.1 4930455F16Rik (from geneSymbol) AK015463 uc336lmg.1 uc336lmg.1 
ENSMUST00000335540.1 Far2os1 ENSMUST00000335540.1 Far2os1 (from geneSymbol) uc336lmx.1 uc336lmx.1 
ENSMUST00000335543.1 ENSMUSG00000136394 ENSMUST00000335543.1 ENSMUSG00000136394 (from geneSymbol) uc336lna.1 uc336lna.1 
ENSMUST00000335544.1 ENSMUSG00000136395 ENSMUST00000335544.1 ENSMUSG00000136395 (from geneSymbol) uc336lnb.1 uc336lnb.1 
ENSMUST00000335545.1 ENSMUSG00000136396 ENSMUST00000335545.1 ENSMUSG00000136396 (from geneSymbol) uc336lnc.1 uc336lnc.1 
ENSMUST00000335549.1 ENSMUSG00000136398 ENSMUST00000335549.1 ENSMUSG00000136398 (from geneSymbol) uc336lnf.1 uc336lnf.1 
ENSMUST00000335556.1 ENSMUSG00000136399 ENSMUST00000335556.1 ENSMUSG00000136399 (from geneSymbol) uc336lnm.1 uc336lnm.1 
ENSMUST00000335566.1 ENSMUSG00000136400 ENSMUST00000335566.1 ENSMUSG00000136400 (from geneSymbol) uc336lnw.1 uc336lnw.1 
ENSMUST00000335567.1 ENSMUSG00000136401 ENSMUST00000335567.1 ENSMUSG00000136401 (from geneSymbol) uc336lnx.1 uc336lnx.1 
ENSMUST00000335572.1 ENSMUSG00000136402 ENSMUST00000335572.1 ENSMUSG00000136402 (from geneSymbol) uc336loc.1 uc336loc.1 
ENSMUST00000335573.1 ENSMUSG00000136403 ENSMUST00000335573.1 ENSMUSG00000136403 (from geneSymbol) uc336lod.1 uc336lod.1 
ENSMUST00000335576.1 1700019G24Rik ENSMUST00000335576.1 1700019G24Rik (from geneSymbol) AK006121 uc336log.1 uc336log.1 
ENSMUST00000335587.1 ENSMUSG00000136404 ENSMUST00000335587.1 ENSMUSG00000136404 (from geneSymbol) uc336lor.1 uc336lor.1 
ENSMUST00000335590.1 ENSMUSG00000136405 ENSMUST00000335590.1 ENSMUSG00000136405 (from geneSymbol) uc336lou.1 uc336lou.1 
ENSMUST00000335591.1 ENSMUSG00000136406 ENSMUST00000335591.1 ENSMUSG00000136406 (from geneSymbol) uc336lov.1 uc336lov.1 
ENSMUST00000335593.1 ENSMUSG00000136407 ENSMUST00000335593.1 ENSMUSG00000136407 (from geneSymbol) uc336lox.1 uc336lox.1 
ENSMUST00000335594.1 1700023C21Rik ENSMUST00000335594.1 1700023C21Rik (from geneSymbol) uc336loy.1 uc336loy.1 
ENSMUST00000335601.1 ENSMUSG00000136408 ENSMUST00000335601.1 ENSMUSG00000136408 (from geneSymbol) uc336lpf.1 uc336lpf.1 
ENSMUST00000335602.1 ENSMUSG00000136409 ENSMUST00000335602.1 ENSMUSG00000136409 (from geneSymbol) uc336lpg.1 uc336lpg.1 
ENSMUST00000335606.1 ENSMUSG00000136410 ENSMUST00000335606.1 ENSMUSG00000136410 (from geneSymbol) uc336lpk.1 uc336lpk.1 
ENSMUST00000335607.1 ENSMUSG00000136411 ENSMUST00000335607.1 ENSMUSG00000136411 (from geneSymbol) uc336lpl.1 uc336lpl.1 
ENSMUST00000335608.1 ENSMUSG00000136412 ENSMUST00000335608.1 ENSMUSG00000136412 (from geneSymbol) uc336lpm.1 uc336lpm.1 
ENSMUST00000335609.1 ENSMUSG00000136413 ENSMUST00000335609.1 ENSMUSG00000136413 (from geneSymbol) uc336lpn.1 uc336lpn.1 
ENSMUST00000335610.1 ENSMUSG00000136414 ENSMUST00000335610.1 ENSMUSG00000136414 (from geneSymbol) uc336lpo.1 uc336lpo.1 
ENSMUST00000335630.1 Gm30420 ENSMUST00000335630.1 Gm30420 (from geneSymbol) uc336lqi.1 uc336lqi.1 
ENSMUST00000335656.1 Gm17172 ENSMUST00000335656.1 Gm17172 (from geneSymbol) uc336lrh.1 uc336lrh.1 
ENSMUST00000335659.1 ENSMUSG00000136416 ENSMUST00000335659.1 ENSMUSG00000136416 (from geneSymbol) uc336lrk.1 uc336lrk.1 
ENSMUST00000335669.1 ENSMUSG00000136417 ENSMUST00000335669.1 ENSMUSG00000136417 (from geneSymbol) uc336lru.1 uc336lru.1 
ENSMUST00000335671.1 ENSMUSG00000136418 ENSMUST00000335671.1 ENSMUSG00000136418 (from geneSymbol) uc336lrw.1 uc336lrw.1 
ENSMUST00000335673.1 ENSMUSG00000136419 ENSMUST00000335673.1 ENSMUSG00000136419 (from geneSymbol) uc336lry.1 uc336lry.1 
ENSMUST00000335674.1 ENSMUSG00000136420 ENSMUST00000335674.1 ENSMUSG00000136420 (from geneSymbol) uc336lrz.1 uc336lrz.1 
ENSMUST00000335675.1 ENSMUSG00000136421 ENSMUST00000335675.1 ENSMUSG00000136421 (from geneSymbol) uc336lsa.1 uc336lsa.1 
ENSMUST00000335676.1 Gm57403 ENSMUST00000335676.1 Gm57403 (from geneSymbol) uc336lsb.1 uc336lsb.1 
ENSMUST00000335678.1 Gm17597 ENSMUST00000335678.1 Gm17597 (from geneSymbol) AK045688 uc336lsd.1 uc336lsd.1 
ENSMUST00000335682.1 3110004A20Rik ENSMUST00000335682.1 3110004A20Rik (from geneSymbol) AK019415 uc336lsh.1 uc336lsh.1 
ENSMUST00000335693.1 ENSMUSG00000136422 ENSMUST00000335693.1 ENSMUSG00000136422 (from geneSymbol) uc336lss.1 uc336lss.1 
ENSMUST00000335694.1 ENSMUSG00000136423 ENSMUST00000335694.1 ENSMUSG00000136423 (from geneSymbol) uc336lst.1 uc336lst.1 
ENSMUST00000335696.1 C130040N14Rik ENSMUST00000335696.1 C130040N14Rik (from geneSymbol) uc336lsv.1 uc336lsv.1 
ENSMUST00000335699.1 ENSMUSG00000136424 ENSMUST00000335699.1 ENSMUSG00000136424 (from geneSymbol) uc336lsy.1 uc336lsy.1 
ENSMUST00000335702.1 ENSMUSG00000136425 ENSMUST00000335702.1 ENSMUSG00000136425 (from geneSymbol) uc336ltb.1 uc336ltb.1 
ENSMUST00000335704.1 ENSMUSG00000136427 ENSMUST00000335704.1 ENSMUSG00000136427 (from geneSymbol) uc336ltc.1 uc336ltc.1 
ENSMUST00000335705.1 ENSMUSG00000136428 ENSMUST00000335705.1 ENSMUSG00000136428 (from geneSymbol) uc336ltd.1 uc336ltd.1 
ENSMUST00000335708.1 ENSMUSG00000136429 ENSMUST00000335708.1 ENSMUSG00000136429 (from geneSymbol) AK005757 uc336ltg.1 uc336ltg.1 
ENSMUST00000335718.1 ENSMUSG00000136430 ENSMUST00000335718.1 ENSMUSG00000136430 (from geneSymbol) uc336ltq.1 uc336ltq.1 
ENSMUST00000335720.1 ENSMUSG00000136431 ENSMUST00000335720.1 ENSMUSG00000136431 (from geneSymbol) uc336lts.1 uc336lts.1 
ENSMUST00000335721.1 ENSMUSG00000136432 ENSMUST00000335721.1 ENSMUSG00000136432 (from geneSymbol) uc336ltt.1 uc336ltt.1 
ENSMUST00000335723.1 ENSMUSG00000136433 ENSMUST00000335723.1 ENSMUSG00000136433 (from geneSymbol) uc336ltv.1 uc336ltv.1 
ENSMUST00000335729.1 ENSMUSG00000136434 ENSMUST00000335729.1 ENSMUSG00000136434 (from geneSymbol) uc336lub.1 uc336lub.1 
ENSMUST00000335730.1 ENSMUSG00000136435 ENSMUST00000335730.1 ENSMUSG00000136435 (from geneSymbol) uc336luc.1 uc336luc.1 
ENSMUST00000335733.1 ENSMUSG00000136436 ENSMUST00000335733.1 ENSMUSG00000136436 (from geneSymbol) uc336luf.1 uc336luf.1 
ENSMUST00000335735.1 ENSMUSG00000136437 ENSMUST00000335735.1 ENSMUSG00000136437 (from geneSymbol) uc336luh.1 uc336luh.1 
ENSMUST00000335737.1 ENSMUSG00000136438 ENSMUST00000335737.1 ENSMUSG00000136438 (from geneSymbol) uc336luj.1 uc336luj.1 
ENSMUST00000335738.1 ENSMUSG00000136439 ENSMUST00000335738.1 ENSMUSG00000136439 (from geneSymbol) uc336luk.1 uc336luk.1 
ENSMUST00000335739.1 ENSMUSG00000136440 ENSMUST00000335739.1 ENSMUSG00000136440 (from geneSymbol) AK016922 uc336lul.1 uc336lul.1 
ENSMUST00000335740.1 ENSMUSG00000136441 ENSMUST00000335740.1 ENSMUSG00000136441 (from geneSymbol) uc336lum.1 uc336lum.1 
ENSMUST00000335741.1 ENSMUSG00000136442 ENSMUST00000335741.1 ENSMUSG00000136442 (from geneSymbol) uc336lun.1 uc336lun.1 
ENSMUST00000335742.1 ENSMUSG00000136443 ENSMUST00000335742.1 ENSMUSG00000136443 (from geneSymbol) uc336luo.1 uc336luo.1 
ENSMUST00000335747.1 4930471E19Rik ENSMUST00000335747.1 4930471E19Rik (from geneSymbol) AK015549 uc336lut.1 uc336lut.1 
ENSMUST00000335767.1 ENSMUSG00000136444 ENSMUST00000335767.1 ENSMUSG00000136444 (from geneSymbol) uc336lvn.1 uc336lvn.1 
ENSMUST00000335768.1 ENSMUSG00000136445 ENSMUST00000335768.1 ENSMUSG00000136445 (from geneSymbol) uc336lvo.1 uc336lvo.1 
ENSMUST00000335770.1 ENSMUSG00000136446 ENSMUST00000335770.1 ENSMUSG00000136446 (from geneSymbol) uc336lvq.1 uc336lvq.1 
ENSMUST00000335771.1 ENSMUSG00000136447 ENSMUST00000335771.1 ENSMUSG00000136447 (from geneSymbol) uc336lvr.1 uc336lvr.1 
ENSMUST00000335775.1 Gm38250 ENSMUST00000335775.1 Gm38250 (from geneSymbol) uc336lvv.1 uc336lvv.1 
ENSMUST00000335798.1 ENSMUSG00000136448 ENSMUST00000335798.1 ENSMUSG00000136448 (from geneSymbol) uc336lws.1 uc336lws.1 
ENSMUST00000335799.1 ENSMUSG00000136449 ENSMUST00000335799.1 ENSMUSG00000136449 (from geneSymbol) uc336lwt.1 uc336lwt.1 
ENSMUST00000335800.1 ENSMUSG00000136450 ENSMUST00000335800.1 ENSMUSG00000136450 (from geneSymbol) uc336lwu.1 uc336lwu.1 
ENSMUST00000335801.1 ENSMUSG00000136451 ENSMUST00000335801.1 ENSMUSG00000136451 (from geneSymbol) uc336lwv.1 uc336lwv.1 
ENSMUST00000335804.1 ENSMUSG00000136452 ENSMUST00000335804.1 ENSMUSG00000136452 (from geneSymbol) uc336lwy.1 uc336lwy.1 
ENSMUST00000335805.1 9630013D21Rik ENSMUST00000335805.1 9630013D21Rik (from geneSymbol) AK052880 uc336lwz.1 uc336lwz.1 
ENSMUST00000335884.1 ENSMUSG00000136453 ENSMUST00000335884.1 ENSMUSG00000136453 (from geneSymbol) uc336lzz.1 uc336lzz.1 
ENSMUST00000335885.1 ENSMUSG00000136454 ENSMUST00000335885.1 ENSMUSG00000136454 (from geneSymbol) uc336maa.1 uc336maa.1 
ENSMUST00000335887.1 ENSMUSG00000136455 ENSMUST00000335887.1 ENSMUSG00000136455 (from geneSymbol) uc336mac.1 uc336mac.1 
ENSMUST00000335889.1 Gm44987 ENSMUST00000335889.1 Gm44987 (from geneSymbol) uc336mae.1 uc336mae.1 
ENSMUST00000335893.1 Gm10248 ENSMUST00000335893.1 Gm10248 (from geneSymbol) AY512910 uc336mai.1 uc336mai.1 
ENSMUST00000335899.1 ENSMUSG00000136456 ENSMUST00000335899.1 ENSMUSG00000136456 (from geneSymbol) uc336mao.1 uc336mao.1 
ENSMUST00000335903.1 Gm56710 ENSMUST00000335903.1 Gm56710 (from geneSymbol) uc336mas.1 uc336mas.1 
ENSMUST00000335908.1 ENSMUSG00000136457 ENSMUST00000335908.1 ENSMUSG00000136457 (from geneSymbol) uc336max.1 uc336max.1 
ENSMUST00000335909.1 ENSMUSG00000136458 ENSMUST00000335909.1 ENSMUSG00000136458 (from geneSymbol) uc336may.1 uc336may.1 
ENSMUST00000335910.1 ENSMUSG00000136459 ENSMUST00000335910.1 ENSMUSG00000136459 (from geneSymbol) uc336maz.1 uc336maz.1 
ENSMUST00000335912.1 Gm50423 ENSMUST00000335912.1 Gm50423 (from geneSymbol) uc336mbb.1 uc336mbb.1 
ENSMUST00000335917.1 Gm14596 ENSMUST00000335917.1 Gm14596 (from geneSymbol) BC108390 uc336mbg.1 uc336mbg.1 
ENSMUST00000335923.1 ENSMUSG00000136461 ENSMUST00000335923.1 ENSMUSG00000136461 (from geneSymbol) uc336mbm.1 uc336mbm.1 
ENSMUST00000335926.1 ENSMUSG00000136462 ENSMUST00000335926.1 ENSMUSG00000136462 (from geneSymbol) uc336mbp.1 uc336mbp.1 
ENSMUST00000335928.1 ENSMUSG00000136463 ENSMUST00000335928.1 ENSMUSG00000136463 (from geneSymbol) uc336mbr.1 uc336mbr.1 
ENSMUST00000335930.1 ENSMUSG00000136464 ENSMUST00000335930.1 ENSMUSG00000136464 (from geneSymbol) uc336mbt.1 uc336mbt.1 
ENSMUST00000335931.1 ENSMUSG00000136465 ENSMUST00000335931.1 ENSMUSG00000136465 (from geneSymbol) uc336mbu.1 uc336mbu.1 
ENSMUST00000335936.1 ENSMUSG00000136466 ENSMUST00000335936.1 ENSMUSG00000136466 (from geneSymbol) uc336mbz.1 uc336mbz.1 
ENSMUST00000335939.1 ENSMUSG00000136467 ENSMUST00000335939.1 ENSMUSG00000136467 (from geneSymbol) uc336mcc.1 uc336mcc.1 
ENSMUST00000335943.1 ENSMUSG00000136468 ENSMUST00000335943.1 ENSMUSG00000136468 (from geneSymbol) uc336mcg.1 uc336mcg.1 
ENSMUST00000335944.1 ENSMUSG00000136469 ENSMUST00000335944.1 ENSMUSG00000136469 (from geneSymbol) uc336mch.1 uc336mch.1 
ENSMUST00000335945.1 ENSMUSG00000136470 ENSMUST00000335945.1 ENSMUSG00000136470 (from geneSymbol) uc336mci.1 uc336mci.1 
ENSMUST00000335947.1 ENSMUSG00000136471 ENSMUST00000335947.1 ENSMUSG00000136471 (from geneSymbol) uc336mck.1 uc336mck.1 
ENSMUST00000335949.1 ENSMUSG00000136472 ENSMUST00000335949.1 ENSMUSG00000136472 (from geneSymbol) uc336mcm.1 uc336mcm.1 
ENSMUST00000335950.1 ENSMUSG00000136473 ENSMUST00000335950.1 ENSMUSG00000136473 (from geneSymbol) uc336mcn.1 uc336mcn.1 
ENSMUST00000335955.1 ENSMUSG00000136474 ENSMUST00000335955.1 ENSMUSG00000136474 (from geneSymbol) uc336mcs.1 uc336mcs.1 
ENSMUST00000335957.1 ENSMUSG00000136475 ENSMUST00000335957.1 ENSMUSG00000136475 (from geneSymbol) uc336mcu.1 uc336mcu.1 
ENSMUST00000335959.1 ENSMUSG00000136476 ENSMUST00000335959.1 ENSMUSG00000136476 (from geneSymbol) uc336mcw.1 uc336mcw.1 
ENSMUST00000335969.1 4930471C04Rik ENSMUST00000335969.1 4930471C04Rik (from geneSymbol) uc336mdg.1 uc336mdg.1 
ENSMUST00000335978.1 ENSMUSG00000136477 ENSMUST00000335978.1 ENSMUSG00000136477 (from geneSymbol) uc336mdp.1 uc336mdp.1 
ENSMUST00000335979.1 ENSMUSG00000136478 ENSMUST00000335979.1 ENSMUSG00000136478 (from geneSymbol) uc336mdq.1 uc336mdq.1 
ENSMUST00000335981.1 ENSMUSG00000136479 ENSMUST00000335981.1 ENSMUSG00000136479 (from geneSymbol) uc336mds.1 uc336mds.1 
ENSMUST00000335982.1 ENSMUSG00000136480 ENSMUST00000335982.1 ENSMUSG00000136480 (from geneSymbol) uc336mdt.1 uc336mdt.1 
ENSMUST00000335992.1 ENSMUSG00000136481 ENSMUST00000335992.1 ENSMUSG00000136481 (from geneSymbol) uc336med.1 uc336med.1 
ENSMUST00000335998.1 ENSMUSG00000136482 ENSMUST00000335998.1 ENSMUSG00000136482 (from geneSymbol) KY468129 uc336mej.1 uc336mej.1 
ENSMUST00000336001.1 ENSMUSG00000136484 ENSMUST00000336001.1 ENSMUSG00000136484 (from geneSymbol) uc336mel.1 uc336mel.1 
ENSMUST00000336007.1 ENSMUSG00000136485 ENSMUST00000336007.1 ENSMUSG00000136485 (from geneSymbol) uc336mer.1 uc336mer.1 
ENSMUST00000336010.1 ENSMUSG00000136486 ENSMUST00000336010.1 ENSMUSG00000136486 (from geneSymbol) AK018857 uc336meu.1 uc336meu.1 
ENSMUST00000336011.1 ENSMUSG00000136487 ENSMUST00000336011.1 ENSMUSG00000136487 (from geneSymbol) uc336mev.1 uc336mev.1 
ENSMUST00000336012.1 ENSMUSG00000136488 ENSMUST00000336012.1 ENSMUSG00000136488 (from geneSymbol) uc336mew.1 uc336mew.1 
ENSMUST00000336014.1 ENSMUSG00000136489 ENSMUST00000336014.1 ENSMUSG00000136489 (from geneSymbol) uc336mey.1 uc336mey.1 
ENSMUST00000336017.1 ENSMUSG00000136491 ENSMUST00000336017.1 ENSMUSG00000136491 (from geneSymbol) uc336mfa.1 uc336mfa.1 
ENSMUST00000336019.1 ENSMUSG00000136492 ENSMUST00000336019.1 ENSMUSG00000136492 (from geneSymbol) uc336mfc.1 uc336mfc.1 
ENSMUST00000336029.1 ENSMUSG00000136493 ENSMUST00000336029.1 ENSMUSG00000136493 (from geneSymbol) AK006850 uc336mfm.1 uc336mfm.1 
ENSMUST00000336032.1 Gm20033 ENSMUST00000336032.1 Gm20033 (from geneSymbol) uc336mfp.1 uc336mfp.1 
ENSMUST00000336066.1 ENSMUSG00000136494 ENSMUST00000336066.1 ENSMUSG00000136494 (from geneSymbol) uc336mgx.1 uc336mgx.1 
ENSMUST00000336080.1 ENSMUSG00000136495 ENSMUST00000336080.1 ENSMUSG00000136495 (from geneSymbol) uc336mhl.1 uc336mhl.1 
ENSMUST00000336081.1 ENSMUSG00000136496 ENSMUST00000336081.1 ENSMUSG00000136496 (from geneSymbol) uc336mhm.1 uc336mhm.1 
ENSMUST00000336082.1 ENSMUSG00000136497 ENSMUST00000336082.1 ENSMUSG00000136497 (from geneSymbol) uc336mhn.1 uc336mhn.1 
ENSMUST00000336083.1 ENSMUSG00000136498 ENSMUST00000336083.1 ENSMUSG00000136498 (from geneSymbol) uc336mho.1 uc336mho.1 
ENSMUST00000336084.1 ENSMUSG00000136499 ENSMUST00000336084.1 ENSMUSG00000136499 (from geneSymbol) uc336mhp.1 uc336mhp.1 
ENSMUST00000336088.1 ENSMUSG00000136500 ENSMUST00000336088.1 ENSMUSG00000136500 (from geneSymbol) uc336mht.1 uc336mht.1 
ENSMUST00000336089.1 ENSMUSG00000136501 ENSMUST00000336089.1 ENSMUSG00000136501 (from geneSymbol) uc336mhu.1 uc336mhu.1 
ENSMUST00000336122.1 ENSMUSG00000136502 ENSMUST00000336122.1 ENSMUSG00000136502 (from geneSymbol) uc336mjb.1 uc336mjb.1 
ENSMUST00000336123.1 ENSMUSG00000136503 ENSMUST00000336123.1 ENSMUSG00000136503 (from geneSymbol) uc336mjc.1 uc336mjc.1 
ENSMUST00000336124.1 4933400L20Rik ENSMUST00000336124.1 4933400L20Rik (from geneSymbol) AK016594 uc336mjd.1 uc336mjd.1 
ENSMUST00000336183.1 ENSMUSG00000136504 ENSMUST00000336183.1 ENSMUSG00000136504 (from geneSymbol) uc336mlk.1 uc336mlk.1 
ENSMUST00000336185.1 ENSMUSG00000136505 ENSMUST00000336185.1 ENSMUSG00000136505 (from geneSymbol) uc336mlm.1 uc336mlm.1 
ENSMUST00000336188.1 ENSMUSG00000136506 ENSMUST00000336188.1 ENSMUSG00000136506 (from geneSymbol) uc336mlp.1 uc336mlp.1 
ENSMUST00000336189.1 ENSMUSG00000136507 ENSMUST00000336189.1 ENSMUSG00000136507 (from geneSymbol) uc336mlq.1 uc336mlq.1 
ENSMUST00000336190.1 ENSMUSG00000136508 ENSMUST00000336190.1 ENSMUSG00000136508 (from geneSymbol) uc336mlr.1 uc336mlr.1 
ENSMUST00000336192.1 ENSMUSG00000136509 ENSMUST00000336192.1 ENSMUSG00000136509 (from geneSymbol) uc336mlt.1 uc336mlt.1 
ENSMUST00000336197.1 ENSMUSG00000136510 ENSMUST00000336197.1 ENSMUSG00000136510 (from geneSymbol) uc336mly.1 uc336mly.1 
ENSMUST00000336199.1 ENSMUSG00000136511 ENSMUST00000336199.1 ENSMUSG00000136511 (from geneSymbol) X72697 uc336mma.1 uc336mma.1 
ENSMUST00000336200.1 ENSMUSG00000136512 ENSMUST00000336200.1 ENSMUSG00000136512 (from geneSymbol) uc336mmb.1 uc336mmb.1 
ENSMUST00000336201.1 ENSMUSG00000136513 ENSMUST00000336201.1 ENSMUSG00000136513 (from geneSymbol) uc336mmc.1 uc336mmc.1 
ENSMUST00000336204.1 ENSMUSG00000136514 ENSMUST00000336204.1 ENSMUSG00000136514 (from geneSymbol) uc336mmf.1 uc336mmf.1 
ENSMUST00000336207.1 ENSMUSG00000136515 ENSMUST00000336207.1 ENSMUSG00000136515 (from geneSymbol) uc336mmi.1 uc336mmi.1 
ENSMUST00000336209.1 ENSMUSG00000136516 ENSMUST00000336209.1 ENSMUSG00000136516 (from geneSymbol) uc336mmk.1 uc336mmk.1 
ENSMUST00000336210.1 ENSMUSG00000136517 ENSMUST00000336210.1 ENSMUSG00000136517 (from geneSymbol) uc336mml.1 uc336mml.1 
ENSMUST00000336215.1 ENSMUSG00000136518 ENSMUST00000336215.1 ENSMUSG00000136518 (from geneSymbol) uc336mmq.1 uc336mmq.1 
ENSMUST00000336220.1 ENSMUSG00000136519 ENSMUST00000336220.1 ENSMUSG00000136519 (from geneSymbol) uc336mmv.1 uc336mmv.1 
ENSMUST00000336222.1 1700101I11Rik ENSMUST00000336222.1 1700101I11Rik (from geneSymbol) AK007107 uc336mmx.1 uc336mmx.1 
ENSMUST00000336240.1 ENSMUSG00000136520 ENSMUST00000336240.1 ENSMUSG00000136520 (from geneSymbol) uc336mnp.1 uc336mnp.1 
ENSMUST00000336241.1 ENSMUSG00000136521 ENSMUST00000336241.1 ENSMUSG00000136521 (from geneSymbol) uc336mnq.1 uc336mnq.1 
ENSMUST00000336244.1 ENSMUSG00000136522 ENSMUST00000336244.1 ENSMUSG00000136522 (from geneSymbol) uc336mnt.1 uc336mnt.1 
ENSMUST00000336249.1 ENSMUSG00000136523 ENSMUST00000336249.1 ENSMUSG00000136523 (from geneSymbol) uc336mny.1 uc336mny.1 
ENSMUST00000336250.1 ENSMUSG00000136524 ENSMUST00000336250.1 ENSMUSG00000136524 (from geneSymbol) uc336mnz.1 uc336mnz.1 
ENSMUST00000336252.1 ENSMUSG00000136525 ENSMUST00000336252.1 ENSMUSG00000136525 (from geneSymbol) JF446404 uc336mob.1 uc336mob.1 
ENSMUST00000336256.1 ENSMUSG00000136527 ENSMUST00000336256.1 ENSMUSG00000136527 (from geneSymbol) uc336moc.1 uc336moc.1 
ENSMUST00000336258.1 ENSMUSG00000136528 ENSMUST00000336258.1 ENSMUSG00000136528 (from geneSymbol) uc336moe.1 uc336moe.1 
ENSMUST00000336259.1 Gm30455 ENSMUST00000336259.1 Gm30455 (from geneSymbol) uc336mof.1 uc336mof.1 
ENSMUST00000336268.1 ENSMUSG00000136529 ENSMUST00000336268.1 ENSMUSG00000136529 (from geneSymbol) uc336moo.1 uc336moo.1 
ENSMUST00000336270.1 ENSMUSG00000136530 ENSMUST00000336270.1 ENSMUSG00000136530 (from geneSymbol) uc336moq.1 uc336moq.1 
ENSMUST00000336272.1 ENSMUSG00000136531 ENSMUST00000336272.1 ENSMUSG00000136531 (from geneSymbol) uc336mos.1 uc336mos.1 
ENSMUST00000336346.1 ENSMUSG00000136532 ENSMUST00000336346.1 ENSMUSG00000136532 (from geneSymbol) uc336mro.1 uc336mro.1 
ENSMUST00000336348.1 ENSMUSG00000136533 ENSMUST00000336348.1 ENSMUSG00000136533 (from geneSymbol) uc336mrq.1 uc336mrq.1 
ENSMUST00000336356.1 ENSMUSG00000136534 ENSMUST00000336356.1 ENSMUSG00000136534 (from geneSymbol) uc336mry.1 uc336mry.1 
ENSMUST00000336370.1 ENSMUSG00000136535 ENSMUST00000336370.1 ENSMUSG00000136535 (from geneSymbol) uc336msm.1 uc336msm.1 
ENSMUST00000336375.1 Gm40289 ENSMUST00000336375.1 Gm40289 (from geneSymbol) AK030193 uc336msr.1 uc336msr.1 
ENSMUST00000336383.1 Gm34368 ENSMUST00000336383.1 Gm34368 (from geneSymbol) AK132873 uc336msz.1 uc336msz.1 
ENSMUST00000336388.1 ENSMUSG00000136536 ENSMUST00000336388.1 ENSMUSG00000136536 (from geneSymbol) uc336mte.1 uc336mte.1 
ENSMUST00000336393.1 ENSMUSG00000136537 ENSMUST00000336393.1 ENSMUSG00000136537 (from geneSymbol) uc336mtj.1 uc336mtj.1 
ENSMUST00000336394.1 ENSMUSG00000136538 ENSMUST00000336394.1 ENSMUSG00000136538 (from geneSymbol) uc336mtk.1 uc336mtk.1 
ENSMUST00000336397.1 ENSMUSG00000136539 ENSMUST00000336397.1 ENSMUSG00000136539 (from geneSymbol) uc336mtn.1 uc336mtn.1 
ENSMUST00000336413.1 Gm47683 ENSMUST00000336413.1 Gm47683 (from geneSymbol) uc336mud.1 uc336mud.1 
ENSMUST00000336416.1 ENSMUSG00000136540 ENSMUST00000336416.1 ENSMUSG00000136540 (from geneSymbol) uc336mug.1 uc336mug.1 
ENSMUST00000336418.1 ENSMUSG00000136541 ENSMUST00000336418.1 ENSMUSG00000136541 (from geneSymbol) uc336mui.1 uc336mui.1 
ENSMUST00000336424.1 D230022J07Rik ENSMUST00000336424.1 D230022J07Rik (from geneSymbol) AK039065 uc336muo.1 uc336muo.1 
ENSMUST00000336435.1 ENSMUSG00000136542 ENSMUST00000336435.1 ENSMUSG00000136542 (from geneSymbol) LF199648 uc336muz.1 uc336muz.1 
ENSMUST00000336438.1 ENSMUSG00000136543 ENSMUST00000336438.1 ENSMUSG00000136543 (from geneSymbol) uc336mvb.1 uc336mvb.1 
ENSMUST00000336445.1 ENSMUSG00000136544 ENSMUST00000336445.1 ENSMUSG00000136544 (from geneSymbol) uc336mvh.1 uc336mvh.1 
ENSMUST00000336446.1 ENSMUSG00000136545 ENSMUST00000336446.1 ENSMUSG00000136545 (from geneSymbol) uc336mvi.1 uc336mvi.1 
ENSMUST00000336451.1 ENSMUSG00000136546 ENSMUST00000336451.1 ENSMUSG00000136546 (from geneSymbol) uc336mvn.1 uc336mvn.1 
ENSMUST00000336454.1 5330438D12Rik ENSMUST00000336454.1 5330438D12Rik (from geneSymbol) uc336mvq.1 uc336mvq.1 
ENSMUST00000336526.1 ENSMUSG00000136547 ENSMUST00000336526.1 ENSMUSG00000136547 (from geneSymbol) uc336myk.1 uc336myk.1 
ENSMUST00000336530.1 ENSMUSG00000136548 ENSMUST00000336530.1 ENSMUSG00000136548 (from geneSymbol) uc336myo.1 uc336myo.1 
ENSMUST00000336532.1 ENSMUSG00000136549 ENSMUST00000336532.1 ENSMUSG00000136549 (from geneSymbol) uc336myq.1 uc336myq.1 
ENSMUST00000336534.1 ENSMUSG00000136550 ENSMUST00000336534.1 ENSMUSG00000136550 (from geneSymbol) uc336mys.1 uc336mys.1 
ENSMUST00000336541.1 ENSMUSG00000136551 ENSMUST00000336541.1 ENSMUSG00000136551 (from geneSymbol) uc336myz.1 uc336myz.1 
ENSMUST00000336542.1 ENSMUSG00000136552 ENSMUST00000336542.1 ENSMUSG00000136552 (from geneSymbol) uc336mza.1 uc336mza.1 
ENSMUST00000336543.1 ENSMUSG00000136553 ENSMUST00000336543.1 ENSMUSG00000136553 (from geneSymbol) uc336mzb.1 uc336mzb.1 
ENSMUST00000336545.1 ENSMUSG00000136554 ENSMUST00000336545.1 ENSMUSG00000136554 (from geneSymbol) uc336mzd.1 uc336mzd.1 
ENSMUST00000336553.1 ENSMUSG00000136555 ENSMUST00000336553.1 ENSMUSG00000136555 (from geneSymbol) uc336mzl.1 uc336mzl.1 
ENSMUST00000336555.1 ENSMUSG00000136556 ENSMUST00000336555.1 ENSMUSG00000136556 (from geneSymbol) uc336mzn.1 uc336mzn.1 
ENSMUST00000336556.1 ENSMUSG00000136557 ENSMUST00000336556.1 ENSMUSG00000136557 (from geneSymbol) uc336mzo.1 uc336mzo.1 
ENSMUST00000336557.1 ENSMUSG00000136558 ENSMUST00000336557.1 ENSMUSG00000136558 (from geneSymbol) uc336mzp.1 uc336mzp.1 
ENSMUST00000336559.1 Gm45346 ENSMUST00000336559.1 Gm45346 (from geneSymbol) uc336mzr.1 uc336mzr.1 
ENSMUST00000336562.1 9230104M06Rik ENSMUST00000336562.1 9230104M06Rik (from geneSymbol) uc336mzu.1 uc336mzu.1 
ENSMUST00000336568.1 ENSMUSG00000136559 ENSMUST00000336568.1 ENSMUSG00000136559 (from geneSymbol) uc336naa.1 uc336naa.1 
ENSMUST00000336570.1 ENSMUSG00000136560 ENSMUST00000336570.1 ENSMUSG00000136560 (from geneSymbol) uc336nac.1 uc336nac.1 
ENSMUST00000336571.1 ENSMUSG00000136561 ENSMUST00000336571.1 ENSMUSG00000136561 (from geneSymbol) uc336nad.1 uc336nad.1 
ENSMUST00000336572.1 ENSMUSG00000136562 ENSMUST00000336572.1 ENSMUSG00000136562 (from geneSymbol) uc336nae.1 uc336nae.1 
ENSMUST00000336573.1 ENSMUSG00000136563 ENSMUST00000336573.1 ENSMUSG00000136563 (from geneSymbol) uc336naf.1 uc336naf.1 
ENSMUST00000336574.1 ENSMUSG00000136564 ENSMUST00000336574.1 ENSMUSG00000136564 (from geneSymbol) uc336nag.1 uc336nag.1 
ENSMUST00000336575.1 ENSMUSG00000136565 ENSMUST00000336575.1 ENSMUSG00000136565 (from geneSymbol) uc336nah.1 uc336nah.1 
ENSMUST00000336577.1 ENSMUSG00000136566 ENSMUST00000336577.1 ENSMUSG00000136566 (from geneSymbol) uc336naj.1 uc336naj.1 
ENSMUST00000336583.1 ENSMUSG00000136568 ENSMUST00000336583.1 ENSMUSG00000136568 (from geneSymbol) uc336nao.1 uc336nao.1 
ENSMUST00000336585.1 ENSMUSG00000136569 ENSMUST00000336585.1 ENSMUSG00000136569 (from geneSymbol) uc336naq.1 uc336naq.1 
ENSMUST00000336586.1 ENSMUSG00000136570 ENSMUST00000336586.1 ENSMUSG00000136570 (from geneSymbol) uc336nar.1 uc336nar.1 
ENSMUST00000336587.1 ENSMUSG00000136571 ENSMUST00000336587.1 ENSMUSG00000136571 (from geneSymbol) uc336nas.1 uc336nas.1 
ENSMUST00000336589.1 ENSMUSG00000136572 ENSMUST00000336589.1 ENSMUSG00000136572 (from geneSymbol) uc336nau.1 uc336nau.1 
ENSMUST00000336590.1 ENSMUSG00000136573 ENSMUST00000336590.1 ENSMUSG00000136573 (from geneSymbol) uc336nav.1 uc336nav.1 
ENSMUST00000336592.1 ENSMUSG00000136574 ENSMUST00000336592.1 ENSMUSG00000136574 (from geneSymbol) uc336nax.1 uc336nax.1 
ENSMUST00000336593.1 Gm9939 ENSMUST00000336593.1 Gm9939 (from geneSymbol) uc336nay.1 uc336nay.1 
ENSMUST00000336609.1 ENSMUSG00000136575 ENSMUST00000336609.1 ENSMUSG00000136575 (from geneSymbol) uc336nbo.1 uc336nbo.1 
ENSMUST00000336614.1 ENSMUSG00000136576 ENSMUST00000336614.1 ENSMUSG00000136576 (from geneSymbol) uc336nbt.1 uc336nbt.1 
ENSMUST00000336615.1 ENSMUSG00000136577 ENSMUST00000336615.1 ENSMUSG00000136577 (from geneSymbol) uc336nbu.1 uc336nbu.1 
ENSMUST00000336617.1 ENSMUSG00000136578 ENSMUST00000336617.1 ENSMUSG00000136578 (from geneSymbol) uc336nbw.1 uc336nbw.1 
ENSMUST00000336624.1 ENSMUSG00000136579 ENSMUST00000336624.1 ENSMUSG00000136579 (from geneSymbol) uc336ncd.1 uc336ncd.1 
ENSMUST00000336626.1 ENSMUSG00000136581 ENSMUST00000336626.1 ENSMUSG00000136581 (from geneSymbol) uc336nce.1 uc336nce.1 
ENSMUST00000336629.1 Gm47926 ENSMUST00000336629.1 Gm47926 (from geneSymbol) uc336nch.1 uc336nch.1 
ENSMUST00000336634.1 ENSMUSG00000136582 ENSMUST00000336634.1 ENSMUSG00000136582 (from geneSymbol) LF197091 uc336ncl.1 uc336ncl.1 
ENSMUST00000336637.1 ENSMUSG00000136583 ENSMUST00000336637.1 ENSMUSG00000136583 (from geneSymbol) uc336nco.1 uc336nco.1 
ENSMUST00000336641.1 Gm13709 ENSMUST00000336641.1 Gm13709 (from geneSymbol) AK131678 uc336ncs.1 uc336ncs.1 
ENSMUST00000336642.1 ENSMUSG00000136584 ENSMUST00000336642.1 ENSMUSG00000136584 (from geneSymbol) uc336nct.1 uc336nct.1 
ENSMUST00000336643.1 ENSMUSG00000136585 ENSMUST00000336643.1 ENSMUSG00000136585 (from geneSymbol) uc336ncu.1 uc336ncu.1 
ENSMUST00000336648.1 ENSMUSG00000136586 ENSMUST00000336648.1 ENSMUSG00000136586 (from geneSymbol) uc336ncz.1 uc336ncz.1 
ENSMUST00000336649.1 ENSMUSG00000136587 ENSMUST00000336649.1 ENSMUSG00000136587 (from geneSymbol) uc336nda.1 uc336nda.1 
ENSMUST00000336650.1 ENSMUSG00000136588 ENSMUST00000336650.1 ENSMUSG00000136588 (from geneSymbol) uc336ndb.1 uc336ndb.1 
ENSMUST00000336653.1 ENSMUSG00000136589 ENSMUST00000336653.1 ENSMUSG00000136589 (from geneSymbol) uc336nde.1 uc336nde.1 
ENSMUST00000336654.1 ENSMUSG00000136590 ENSMUST00000336654.1 ENSMUSG00000136590 (from geneSymbol) uc336ndf.1 uc336ndf.1 
ENSMUST00000336655.1 ENSMUSG00000136591 ENSMUST00000336655.1 ENSMUSG00000136591 (from geneSymbol) uc336ndg.1 uc336ndg.1 
ENSMUST00000336660.1 ENSMUSG00000136592 ENSMUST00000336660.1 ENSMUSG00000136592 (from geneSymbol) uc336ndl.1 uc336ndl.1 
ENSMUST00000336661.1 ENSMUSG00000136593 ENSMUST00000336661.1 ENSMUSG00000136593 (from geneSymbol) uc336ndm.1 uc336ndm.1 
ENSMUST00000336662.1 ENSMUSG00000136594 ENSMUST00000336662.1 ENSMUSG00000136594 (from geneSymbol) uc336ndn.1 uc336ndn.1 
ENSMUST00000336663.1 ENSMUSG00000136595 ENSMUST00000336663.1 ENSMUSG00000136595 (from geneSymbol) uc336ndo.1 uc336ndo.1 
ENSMUST00000336671.1 ENSMUSG00000136596 ENSMUST00000336671.1 ENSMUSG00000136596 (from geneSymbol) uc336ndw.1 uc336ndw.1 
ENSMUST00000336673.1 ENSMUSG00000136597 ENSMUST00000336673.1 ENSMUSG00000136597 (from geneSymbol) uc336ndy.1 uc336ndy.1 
ENSMUST00000336674.1 ENSMUSG00000136598 ENSMUST00000336674.1 ENSMUSG00000136598 (from geneSymbol) uc336ndz.1 uc336ndz.1 
ENSMUST00000336675.1 ENSMUSG00000136599 ENSMUST00000336675.1 ENSMUSG00000136599 (from geneSymbol) uc336nea.1 uc336nea.1 
ENSMUST00000336676.1 ENSMUSG00000136600 ENSMUST00000336676.1 ENSMUSG00000136600 (from geneSymbol) uc336neb.1 uc336neb.1 
ENSMUST00000336678.1 ENSMUSG00000136601 ENSMUST00000336678.1 ENSMUSG00000136601 (from geneSymbol) uc336ned.1 uc336ned.1 
ENSMUST00000336679.1 ENSMUSG00000136602 ENSMUST00000336679.1 ENSMUSG00000136602 (from geneSymbol) uc336nee.1 uc336nee.1 
ENSMUST00000336680.1 ENSMUSG00000136603 ENSMUST00000336680.1 ENSMUSG00000136603 (from geneSymbol) LF193830 uc336nef.1 uc336nef.1 
ENSMUST00000336681.1 Gm33347 ENSMUST00000336681.1 Gm33347 (from geneSymbol) uc336neg.1 uc336neg.1 
ENSMUST00000336685.1 ENSMUSG00000136604 ENSMUST00000336685.1 ENSMUSG00000136604 (from geneSymbol) uc336nej.1 uc336nej.1 
ENSMUST00000336686.1 ENSMUSG00000136605 ENSMUST00000336686.1 ENSMUSG00000136605 (from geneSymbol) LF202280 uc336nek.1 uc336nek.1 
ENSMUST00000336687.1 ENSMUSG00000136606 ENSMUST00000336687.1 ENSMUSG00000136606 (from geneSymbol) uc336nel.1 uc336nel.1 
ENSMUST00000336688.1 Gm43154 ENSMUST00000336688.1 Gm43154 (from geneSymbol) KY468081 uc336nem.1 uc336nem.1 
ENSMUST00000336757.1 ENSMUSG00000136607 ENSMUST00000336757.1 ENSMUSG00000136607 (from geneSymbol) uc336nhd.1 uc336nhd.1 
ENSMUST00000336762.1 ENSMUSG00000136608 ENSMUST00000336762.1 ENSMUSG00000136608 (from geneSymbol) uc336nhi.1 uc336nhi.1 
ENSMUST00000336764.1 Gm35748 ENSMUST00000336764.1 Gm35748 (from geneSymbol) uc336nhk.1 uc336nhk.1 
ENSMUST00000336770.1 ENSMUSG00000136609 ENSMUST00000336770.1 ENSMUSG00000136609 (from geneSymbol) uc336nhq.1 uc336nhq.1 
ENSMUST00000336771.1 ENSMUSG00000136610 ENSMUST00000336771.1 ENSMUSG00000136610 (from geneSymbol) uc336nhr.1 uc336nhr.1 
ENSMUST00000336772.1 ENSMUSG00000136611 ENSMUST00000336772.1 ENSMUSG00000136611 (from geneSymbol) uc336nhs.1 uc336nhs.1 
ENSMUST00000336774.1 ENSMUSG00000136612 ENSMUST00000336774.1 ENSMUSG00000136612 (from geneSymbol) uc336nhu.1 uc336nhu.1 
ENSMUST00000336776.1 ENSMUSG00000136613 ENSMUST00000336776.1 ENSMUSG00000136613 (from geneSymbol) uc336nhw.1 uc336nhw.1 
ENSMUST00000336777.1 ENSMUSG00000136614 ENSMUST00000336777.1 ENSMUSG00000136614 (from geneSymbol) uc336nhx.1 uc336nhx.1 
ENSMUST00000336778.1 ENSMUSG00000136615 ENSMUST00000336778.1 ENSMUSG00000136615 (from geneSymbol) uc336nhy.1 uc336nhy.1 
ENSMUST00000336779.1 ENSMUSG00000136616 ENSMUST00000336779.1 ENSMUSG00000136616 (from geneSymbol) uc336nhz.1 uc336nhz.1 
ENSMUST00000336780.1 ENSMUSG00000136617 ENSMUST00000336780.1 ENSMUSG00000136617 (from geneSymbol) uc336nia.1 uc336nia.1 
ENSMUST00000336781.1 ENSMUSG00000136618 ENSMUST00000336781.1 ENSMUSG00000136618 (from geneSymbol) uc336nib.1 uc336nib.1 
ENSMUST00000336785.1 C130060C02Rik ENSMUST00000336785.1 C130060C02Rik (from geneSymbol) AK163425 uc336nif.1 uc336nif.1 
ENSMUST00000336792.1 ENSMUSG00000136619 ENSMUST00000336792.1 ENSMUSG00000136619 (from geneSymbol) uc336nim.1 uc336nim.1 
ENSMUST00000336793.1 ENSMUSG00000136620 ENSMUST00000336793.1 ENSMUSG00000136620 (from geneSymbol) uc336nin.1 uc336nin.1 
ENSMUST00000336794.1 ENSMUSG00000136621 ENSMUST00000336794.1 ENSMUSG00000136621 (from geneSymbol) uc336nio.1 uc336nio.1 
ENSMUST00000336796.1 5031425E22Rik ENSMUST00000336796.1 5031425E22Rik (from geneSymbol) AK017143 uc336niq.1 uc336niq.1 
ENSMUST00000336855.1 Gm14024 ENSMUST00000336855.1 Gm14024 (from geneSymbol) uc336nkx.1 uc336nkx.1 
ENSMUST00000336857.1 ENSMUSG00000136622 ENSMUST00000336857.1 ENSMUSG00000136622 (from geneSymbol) uc336nkz.1 uc336nkz.1 
ENSMUST00000336860.1 ENSMUSG00000136623 ENSMUST00000336860.1 ENSMUSG00000136623 (from geneSymbol) uc336nlc.1 uc336nlc.1 
ENSMUST00000336862.1 ENSMUSG00000136624 ENSMUST00000336862.1 ENSMUSG00000136624 (from geneSymbol) uc336nle.1 uc336nle.1 
ENSMUST00000336865.1 Gm13707 ENSMUST00000336865.1 Gm13707 (from geneSymbol) KY467872 uc336nlh.1 uc336nlh.1 
ENSMUST00000336867.1 ENSMUSG00000136625 ENSMUST00000336867.1 ENSMUSG00000136625 (from geneSymbol) LF193483 uc336nlj.1 uc336nlj.1 
ENSMUST00000336870.1 ENSMUSG00000136626 ENSMUST00000336870.1 ENSMUSG00000136626 (from geneSymbol) uc336nlm.1 uc336nlm.1 
ENSMUST00000336871.1 ENSMUSG00000136627 ENSMUST00000336871.1 ENSMUSG00000136627 (from geneSymbol) uc336nln.1 uc336nln.1 
ENSMUST00000336872.1 Gm31499 ENSMUST00000336872.1 Gm31499 (from geneSymbol) uc336nlo.1 uc336nlo.1 
ENSMUST00000336875.1 ENSMUSG00000136628 ENSMUST00000336875.1 ENSMUSG00000136628 (from geneSymbol) uc336nlr.1 uc336nlr.1 
ENSMUST00000336876.1 ENSMUSG00000136629 ENSMUST00000336876.1 ENSMUSG00000136629 (from geneSymbol) uc336nls.1 uc336nls.1 
ENSMUST00000336879.1 ENSMUSG00000136630 ENSMUST00000336879.1 ENSMUSG00000136630 (from geneSymbol) uc336nlv.1 uc336nlv.1 
ENSMUST00000336880.1 ENSMUSG00000136631 ENSMUST00000336880.1 ENSMUSG00000136631 (from geneSymbol) uc336nlw.1 uc336nlw.1 
ENSMUST00000336882.1 Mir124a-1hg ENSMUST00000336882.1 Mir124a-1hg (from geneSymbol) AK044422 uc336nly.1 uc336nly.1 
ENSMUST00000336889.1 ENSMUSG00000136632 ENSMUST00000336889.1 ENSMUSG00000136632 (from geneSymbol) uc336nmf.1 uc336nmf.1 
ENSMUST00000336892.1 ENSMUSG00000136633 ENSMUST00000336892.1 ENSMUSG00000136633 (from geneSymbol) uc336nmi.1 uc336nmi.1 
ENSMUST00000336893.1 ENSMUSG00000136634 ENSMUST00000336893.1 ENSMUSG00000136634 (from geneSymbol) uc336nmj.1 uc336nmj.1 
ENSMUST00000336894.1 Gm39214 ENSMUST00000336894.1 Gm39214 (from geneSymbol) AK085761 uc336nmk.1 uc336nmk.1 
ENSMUST00000336913.1 ENSMUSG00000136635 ENSMUST00000336913.1 ENSMUSG00000136635 (from geneSymbol) uc336nnd.1 uc336nnd.1 
ENSMUST00000336915.1 ENSMUSG00000136636 ENSMUST00000336915.1 ENSMUSG00000136636 (from geneSymbol) uc336nnf.1 uc336nnf.1 
ENSMUST00000336917.1 Plxna4os3 ENSMUST00000336917.1 Plxna4os3 (from geneSymbol) uc336nnh.1 uc336nnh.1 
ENSMUST00000336920.1 ENSMUSG00000136637 ENSMUST00000336920.1 ENSMUSG00000136637 (from geneSymbol) uc336nnk.1 uc336nnk.1 
ENSMUST00000336922.1 ENSMUSG00000136638 ENSMUST00000336922.1 ENSMUSG00000136638 (from geneSymbol) uc336nnl.1 uc336nnl.1 
ENSMUST00000336923.1 ENSMUSG00000136639 ENSMUST00000336923.1 ENSMUSG00000136639 (from geneSymbol) uc336nnm.1 uc336nnm.1 
ENSMUST00000336924.1 ENSMUSG00000136640 ENSMUST00000336924.1 ENSMUSG00000136640 (from geneSymbol) uc336nnn.1 uc336nnn.1 
ENSMUST00000336926.1 ENSMUSG00000136641 ENSMUST00000336926.1 ENSMUSG00000136641 (from geneSymbol) AK016790 uc336nnp.1 uc336nnp.1 
ENSMUST00000336951.1 ENSMUSG00000136642 ENSMUST00000336951.1 ENSMUSG00000136642 (from geneSymbol) uc336noo.1 uc336noo.1 
ENSMUST00000336952.1 ENSMUSG00000136643 ENSMUST00000336952.1 ENSMUSG00000136643 (from geneSymbol) uc336nop.1 uc336nop.1 
ENSMUST00000336953.1 ENSMUSG00000136644 ENSMUST00000336953.1 ENSMUSG00000136644 (from geneSymbol) uc336noq.1 uc336noq.1 
ENSMUST00000336964.1 ENSMUSG00000136645 ENSMUST00000336964.1 ENSMUSG00000136645 (from geneSymbol) uc336npb.1 uc336npb.1 
ENSMUST00000336966.1 ENSMUSG00000136646 ENSMUST00000336966.1 ENSMUSG00000136646 (from geneSymbol) uc336npd.1 uc336npd.1 
ENSMUST00000336967.1 ENSMUSG00000136647 ENSMUST00000336967.1 ENSMUSG00000136647 (from geneSymbol) uc336npe.1 uc336npe.1 
ENSMUST00000336968.1 ENSMUSG00000136648 ENSMUST00000336968.1 ENSMUSG00000136648 (from geneSymbol) uc336npf.1 uc336npf.1 
ENSMUST00000336973.1 Gm15908 ENSMUST00000336973.1 Gm15908 (from geneSymbol) AK132729 uc336npk.1 uc336npk.1 
ENSMUST00000336981.1 ENSMUSG00000136649 ENSMUST00000336981.1 ENSMUSG00000136649 (from geneSymbol) uc336nps.1 uc336nps.1 
ENSMUST00000336982.1 ENSMUSG00000136650 ENSMUST00000336982.1 ENSMUSG00000136650 (from geneSymbol) uc336npt.1 uc336npt.1 
ENSMUST00000336983.1 ENSMUSG00000136651 ENSMUST00000336983.1 ENSMUSG00000136651 (from geneSymbol) KY467834 uc336npu.1 uc336npu.1 
ENSMUST00000336994.1 ENSMUSG00000136652 ENSMUST00000336994.1 ENSMUSG00000136652 (from geneSymbol) uc336nqf.1 uc336nqf.1 
ENSMUST00000336998.1 ENSMUSG00000136653 ENSMUST00000336998.1 ENSMUSG00000136653 (from geneSymbol) uc336nqj.1 uc336nqj.1 
ENSMUST00000336999.1 ENSMUSG00000136654 ENSMUST00000336999.1 ENSMUSG00000136654 (from geneSymbol) uc336nqk.1 uc336nqk.1 
ENSMUST00000337001.1 ENSMUSG00000136655 ENSMUST00000337001.1 ENSMUSG00000136655 (from geneSymbol) uc336nqm.1 uc336nqm.1 
ENSMUST00000337003.1 ENSMUSG00000136656 ENSMUST00000337003.1 ENSMUSG00000136656 (from geneSymbol) uc336nqo.1 uc336nqo.1 
ENSMUST00000337004.1 ENSMUSG00000136657 ENSMUST00000337004.1 ENSMUSG00000136657 (from geneSymbol) AK019533 uc336nqp.1 uc336nqp.1 
ENSMUST00000337005.1 ENSMUSG00000136658 ENSMUST00000337005.1 ENSMUSG00000136658 (from geneSymbol) uc336nqq.1 uc336nqq.1 
ENSMUST00000337012.1 ENSMUSG00000136659 ENSMUST00000337012.1 ENSMUSG00000136659 (from geneSymbol) uc336nqx.1 uc336nqx.1 
ENSMUST00000337019.1 ENSMUSG00000136660 ENSMUST00000337019.1 ENSMUSG00000136660 (from geneSymbol) uc336nre.1 uc336nre.1 
ENSMUST00000337022.1 Gm31819 ENSMUST00000337022.1 Gm31819 (from geneSymbol) AK141885 uc336nrh.1 uc336nrh.1 
ENSMUST00000337023.1 ENSMUSG00000136661 ENSMUST00000337023.1 ENSMUSG00000136661 (from geneSymbol) uc336nri.1 uc336nri.1 
ENSMUST00000337029.1 ENSMUSG00000136662 ENSMUST00000337029.1 ENSMUSG00000136662 (from geneSymbol) uc336nro.1 uc336nro.1 
ENSMUST00000337030.1 ENSMUSG00000136663 ENSMUST00000337030.1 ENSMUSG00000136663 (from geneSymbol) uc336nrp.1 uc336nrp.1 
ENSMUST00000337032.1 ENSMUSG00000136664 ENSMUST00000337032.1 ENSMUSG00000136664 (from geneSymbol) KY467545 uc336nrr.1 uc336nrr.1 
ENSMUST00000337035.1 ENSMUSG00000136665 ENSMUST00000337035.1 ENSMUSG00000136665 (from geneSymbol) uc336nru.1 uc336nru.1 
ENSMUST00000337036.1 Gm13703 ENSMUST00000337036.1 Gm13703 (from geneSymbol) uc336nrv.1 uc336nrv.1 
ENSMUST00000337037.1 4930580E04Rik ENSMUST00000337037.1 4930580E04Rik (from geneSymbol) AK016337 uc336nrw.1 uc336nrw.1 
ENSMUST00000337038.1 ENSMUSG00000136666 ENSMUST00000337038.1 ENSMUSG00000136666 (from geneSymbol) uc336nrx.1 uc336nrx.1 
ENSMUST00000337039.1 Gm32141 ENSMUST00000337039.1 Gm32141 (from geneSymbol) AK076673 uc336nry.1 uc336nry.1 
ENSMUST00000337154.1 ENSMUSG00000136667 ENSMUST00000337154.1 ENSMUSG00000136667 (from geneSymbol) uc336nwj.1 uc336nwj.1 
ENSMUST00000337155.1 ENSMUSG00000136668 ENSMUST00000337155.1 ENSMUSG00000136668 (from geneSymbol) uc336nwk.1 uc336nwk.1 
ENSMUST00000337174.1 ENSMUSG00000136669 ENSMUST00000337174.1 ENSMUSG00000136669 (from geneSymbol) uc336nxd.1 uc336nxd.1 
ENSMUST00000337176.1 ENSMUSG00000136670 ENSMUST00000337176.1 ENSMUSG00000136670 (from geneSymbol) uc336nxf.1 uc336nxf.1 
ENSMUST00000337178.1 ENSMUSG00000136671 ENSMUST00000337178.1 ENSMUSG00000136671 (from geneSymbol) uc336nxh.1 uc336nxh.1 
ENSMUST00000337179.1 ENSMUSG00000136672 ENSMUST00000337179.1 ENSMUSG00000136672 (from geneSymbol) uc336nxi.1 uc336nxi.1 
ENSMUST00000337180.1 ENSMUSG00000136673 ENSMUST00000337180.1 ENSMUSG00000136673 (from geneSymbol) uc336nxj.1 uc336nxj.1 
ENSMUST00000337181.1 ENSMUSG00000136674 ENSMUST00000337181.1 ENSMUSG00000136674 (from geneSymbol) uc336nxk.1 uc336nxk.1 
ENSMUST00000337183.1 4933402J10Rik ENSMUST00000337183.1 4933402J10Rik (from geneSymbol) BC099582 uc336nxm.1 uc336nxm.1 
ENSMUST00000337197.1 ENSMUSG00000136675 ENSMUST00000337197.1 ENSMUSG00000136675 (from geneSymbol) uc336nya.1 uc336nya.1 
ENSMUST00000337200.1 Gm30934 ENSMUST00000337200.1 Gm30934 (from geneSymbol) uc336nyd.1 uc336nyd.1 
ENSMUST00000337209.1 ENSMUSG00000136676 ENSMUST00000337209.1 ENSMUSG00000136676 (from geneSymbol) uc336nym.1 uc336nym.1 
ENSMUST00000337217.1 ENSMUSG00000136677 ENSMUST00000337217.1 ENSMUSG00000136677 (from geneSymbol) uc336nyu.1 uc336nyu.1 
ENSMUST00000337218.1 ENSMUSG00000136678 ENSMUST00000337218.1 ENSMUSG00000136678 (from geneSymbol) uc336nyv.1 uc336nyv.1 
ENSMUST00000337219.1 ENSMUSG00000136679 ENSMUST00000337219.1 ENSMUSG00000136679 (from geneSymbol) uc336nyw.1 uc336nyw.1 
ENSMUST00000337221.1 ENSMUSG00000136680 ENSMUST00000337221.1 ENSMUSG00000136680 (from geneSymbol) uc336nyy.1 uc336nyy.1 
ENSMUST00000337222.1 ENSMUSG00000136681 ENSMUST00000337222.1 ENSMUSG00000136681 (from geneSymbol) uc336nyz.1 uc336nyz.1 
ENSMUST00000337224.1 ENSMUSG00000136682 ENSMUST00000337224.1 ENSMUSG00000136682 (from geneSymbol) uc336nzb.1 uc336nzb.1 
ENSMUST00000337226.1 ENSMUSG00000136683 ENSMUST00000337226.1 ENSMUSG00000136683 (from geneSymbol) uc336nzd.1 uc336nzd.1 
ENSMUST00000337227.1 ENSMUSG00000136684 ENSMUST00000337227.1 ENSMUSG00000136684 (from geneSymbol) uc336nze.1 uc336nze.1 
ENSMUST00000337228.1 Gm47151 ENSMUST00000337228.1 Gm47151 (from geneSymbol) uc336nzf.1 uc336nzf.1 
ENSMUST00000337229.1 1700065J11Rik ENSMUST00000337229.1 1700065J11Rik (from geneSymbol) AK006894 uc336nzg.1 uc336nzg.1 
ENSMUST00000337246.1 ENSMUSG00000136685 ENSMUST00000337246.1 ENSMUSG00000136685 (from geneSymbol) uc336nzx.1 uc336nzx.1 
ENSMUST00000337247.1 ENSMUSG00000136686 ENSMUST00000337247.1 ENSMUSG00000136686 (from geneSymbol) uc336nzy.1 uc336nzy.1 
ENSMUST00000337248.1 ENSMUSG00000136687 ENSMUST00000337248.1 ENSMUSG00000136687 (from geneSymbol) uc336nzz.1 uc336nzz.1 
ENSMUST00000337254.1 ENSMUSG00000136688 ENSMUST00000337254.1 ENSMUSG00000136688 (from geneSymbol) uc336oaf.1 uc336oaf.1 
ENSMUST00000337260.1 ENSMUSG00000136689 ENSMUST00000337260.1 ENSMUSG00000136689 (from geneSymbol) uc336oal.1 uc336oal.1 
ENSMUST00000337261.1 ENSMUSG00000136690 ENSMUST00000337261.1 ENSMUSG00000136690 (from geneSymbol) uc336oam.1 uc336oam.1 
ENSMUST00000337264.1 ENSMUSG00000136691 ENSMUST00000337264.1 ENSMUSG00000136691 (from geneSymbol) uc336oap.1 uc336oap.1 
ENSMUST00000337273.1 ENSMUSG00000136692 ENSMUST00000337273.1 ENSMUSG00000136692 (from geneSymbol) uc336oay.1 uc336oay.1 
ENSMUST00000337274.1 ENSMUSG00000136693 ENSMUST00000337274.1 ENSMUSG00000136693 (from geneSymbol) uc336oaz.1 uc336oaz.1 
ENSMUST00000337277.1 ENSMUSG00000136694 ENSMUST00000337277.1 ENSMUSG00000136694 (from geneSymbol) uc336obc.1 uc336obc.1 
ENSMUST00000337288.1 ENSMUSG00000136695 ENSMUST00000337288.1 ENSMUSG00000136695 (from geneSymbol) uc336obn.1 uc336obn.1 
ENSMUST00000337291.1 ENSMUSG00000136696 ENSMUST00000337291.1 ENSMUSG00000136696 (from geneSymbol) uc336obq.1 uc336obq.1 
ENSMUST00000337292.1 Gm56558 ENSMUST00000337292.1 Gm56558 (from geneSymbol) uc336obr.1 uc336obr.1 
ENSMUST00000337297.1 ENSMUSG00000136697 ENSMUST00000337297.1 ENSMUSG00000136697 (from geneSymbol) uc336obw.1 uc336obw.1 
ENSMUST00000337298.1 ENSMUSG00000136698 ENSMUST00000337298.1 ENSMUSG00000136698 (from geneSymbol) uc336obx.1 uc336obx.1 
ENSMUST00000337299.1 ENSMUSG00000136699 ENSMUST00000337299.1 ENSMUSG00000136699 (from geneSymbol) uc336oby.1 uc336oby.1 
ENSMUST00000337305.1 ENSMUSG00000136701 ENSMUST00000337305.1 ENSMUSG00000136701 (from geneSymbol) uc336ocd.1 uc336ocd.1 
ENSMUST00000337307.1 ENSMUSG00000136702 ENSMUST00000337307.1 ENSMUSG00000136702 (from geneSymbol) AK079376 uc336ocf.1 uc336ocf.1 
ENSMUST00000337308.1 ENSMUSG00000136703 ENSMUST00000337308.1 ENSMUSG00000136703 (from geneSymbol) uc336ocg.1 uc336ocg.1 
ENSMUST00000337310.1 ENSMUSG00000136704 ENSMUST00000337310.1 ENSMUSG00000136704 (from geneSymbol) uc336oci.1 uc336oci.1 
ENSMUST00000337323.1 Gm48371 ENSMUST00000337323.1 Gm48371 (from geneSymbol) uc336ocv.1 uc336ocv.1 
ENSMUST00000337327.1 ENSMUSG00000136705 ENSMUST00000337327.1 ENSMUSG00000136705 (from geneSymbol) uc336ocz.1 uc336ocz.1 
ENSMUST00000337332.1 ENSMUSG00000136706 ENSMUST00000337332.1 ENSMUSG00000136706 (from geneSymbol) uc336ode.1 uc336ode.1 
ENSMUST00000337333.1 ENSMUSG00000136707 ENSMUST00000337333.1 ENSMUSG00000136707 (from geneSymbol) uc336odf.1 uc336odf.1 
ENSMUST00000337334.1 ENSMUSG00000136708 ENSMUST00000337334.1 ENSMUSG00000136708 (from geneSymbol) LF194725 uc336odg.1 uc336odg.1 
ENSMUST00000337335.1 ENSMUSG00000136709 ENSMUST00000337335.1 ENSMUSG00000136709 (from geneSymbol) uc336odh.1 uc336odh.1 
ENSMUST00000337336.1 ENSMUSG00000136710 ENSMUST00000337336.1 ENSMUSG00000136710 (from geneSymbol) uc336odi.1 uc336odi.1 
ENSMUST00000337337.1 ENSMUSG00000136711 ENSMUST00000337337.1 ENSMUSG00000136711 (from geneSymbol) uc336odj.1 uc336odj.1 
ENSMUST00000337340.1 ENSMUSG00000136712 ENSMUST00000337340.1 ENSMUSG00000136712 (from geneSymbol) uc336odm.1 uc336odm.1 
ENSMUST00000337341.1 ENSMUSG00000136713 ENSMUST00000337341.1 ENSMUSG00000136713 (from geneSymbol) uc336odn.1 uc336odn.1 
ENSMUST00000337344.1 ENSMUSG00000136714 ENSMUST00000337344.1 ENSMUSG00000136714 (from geneSymbol) uc336odq.1 uc336odq.1 
ENSMUST00000337345.1 ENSMUSG00000136715 ENSMUST00000337345.1 ENSMUSG00000136715 (from geneSymbol) uc336odr.1 uc336odr.1 
ENSMUST00000337362.1 ENSMUSG00000136717 ENSMUST00000337362.1 ENSMUSG00000136717 (from geneSymbol) uc336oeh.1 uc336oeh.1 
ENSMUST00000337364.1 Gm37712 ENSMUST00000337364.1 Gm37712 (from geneSymbol) uc336oej.1 uc336oej.1 
ENSMUST00000337384.1 ENSMUSG00000136718 ENSMUST00000337384.1 ENSMUSG00000136718 (from geneSymbol) uc336ofd.1 uc336ofd.1 
ENSMUST00000337385.1 ENSMUSG00000136719 ENSMUST00000337385.1 ENSMUSG00000136719 (from geneSymbol) uc336ofe.1 uc336ofe.1 
ENSMUST00000337387.1 ENSMUSG00000136720 ENSMUST00000337387.1 ENSMUSG00000136720 (from geneSymbol) uc336ofg.1 uc336ofg.1 
ENSMUST00000337388.1 ENSMUSG00000136721 ENSMUST00000337388.1 ENSMUSG00000136721 (from geneSymbol) uc336ofh.1 uc336ofh.1 
ENSMUST00000337390.1 ENSMUSG00000136722 ENSMUST00000337390.1 ENSMUSG00000136722 (from geneSymbol) uc336ofj.1 uc336ofj.1 
ENSMUST00000337393.1 ENSMUSG00000121845 ENSMUST00000337393.1 ENSMUSG00000121845 (from geneSymbol) uc336ofm.1 uc336ofm.1 
ENSMUST00000337398.1 ENSMUSG00000136723 ENSMUST00000337398.1 ENSMUSG00000136723 (from geneSymbol) uc336ofr.1 uc336ofr.1 
ENSMUST00000337403.1 ENSMUSG00000136724 ENSMUST00000337403.1 ENSMUSG00000136724 (from geneSymbol) uc336ofw.1 uc336ofw.1 
ENSMUST00000337404.1 ENSMUSG00000136725 ENSMUST00000337404.1 ENSMUSG00000136725 (from geneSymbol) uc336ofx.1 uc336ofx.1 
ENSMUST00000337405.1 ENSMUSG00000136726 ENSMUST00000337405.1 ENSMUSG00000136726 (from geneSymbol) uc336ofy.1 uc336ofy.1 
ENSMUST00000337406.1 Gm47150 ENSMUST00000337406.1 Gm47150 (from geneSymbol) uc336ofz.1 uc336ofz.1 
ENSMUST00000337407.1 Gm43293 ENSMUST00000337407.1 Gm43293 (from geneSymbol) uc336oga.1 uc336oga.1 
ENSMUST00000337409.1 ENSMUSG00000136727 ENSMUST00000337409.1 ENSMUSG00000136727 (from geneSymbol) uc336ogc.1 uc336ogc.1 
ENSMUST00000337413.1 ENSMUSG00000136728 ENSMUST00000337413.1 ENSMUSG00000136728 (from geneSymbol) uc336ogg.1 uc336ogg.1 
ENSMUST00000337417.1 ENSMUSG00000136730 ENSMUST00000337417.1 ENSMUSG00000136730 (from geneSymbol) uc336ogi.1 uc336ogi.1 
ENSMUST00000337420.1 ENSMUSG00000136731 ENSMUST00000337420.1 ENSMUSG00000136731 (from geneSymbol) uc336ogk.1 uc336ogk.1 
ENSMUST00000337429.1 Gm47915 ENSMUST00000337429.1 Gm47915 (from geneSymbol) AK131778 uc336ogp.1 uc336ogp.1 
ENSMUST00000337430.1 ENSMUSG00000136733 ENSMUST00000337430.1 ENSMUSG00000136733 (from geneSymbol) uc336ogq.1 uc336ogq.1 
ENSMUST00000337431.1 ENSMUSG00000136734 ENSMUST00000337431.1 ENSMUSG00000136734 (from geneSymbol) uc336ogr.1 uc336ogr.1 
ENSMUST00000337432.1 ENSMUSG00000136735 ENSMUST00000337432.1 ENSMUSG00000136735 (from geneSymbol) uc336ogs.1 uc336ogs.1 
ENSMUST00000337433.1 ENSMUSG00000136736 ENSMUST00000337433.1 ENSMUSG00000136736 (from geneSymbol) uc336ogt.1 uc336ogt.1 
ENSMUST00000337440.1 ENSMUSG00000136737 ENSMUST00000337440.1 ENSMUSG00000136737 (from geneSymbol) uc336oha.1 uc336oha.1 
ENSMUST00000337442.1 Gm28536 ENSMUST00000337442.1 Gm28536 (from geneSymbol) uc336ohc.1 uc336ohc.1 
ENSMUST00000337444.1 ENSMUSG00000136738 ENSMUST00000337444.1 ENSMUSG00000136738 (from geneSymbol) uc336ohe.1 uc336ohe.1 
ENSMUST00000337446.1 ENSMUSG00000136739 ENSMUST00000337446.1 ENSMUSG00000136739 (from geneSymbol) uc336ohg.1 uc336ohg.1 
ENSMUST00000337448.1 ENSMUSG00000136740 ENSMUST00000337448.1 ENSMUSG00000136740 (from geneSymbol) uc336ohi.1 uc336ohi.1 
ENSMUST00000337451.1 ENSMUSG00000136741 ENSMUST00000337451.1 ENSMUSG00000136741 (from geneSymbol) uc336ohl.1 uc336ohl.1 
ENSMUST00000337452.1 ENSMUSG00000136742 ENSMUST00000337452.1 ENSMUSG00000136742 (from geneSymbol) uc336ohm.1 uc336ohm.1 
ENSMUST00000337456.1 ENSMUSG00000136743 ENSMUST00000337456.1 ENSMUSG00000136743 (from geneSymbol) uc336ohq.1 uc336ohq.1 
ENSMUST00000337458.1 ENSMUSG00000136744 ENSMUST00000337458.1 ENSMUSG00000136744 (from geneSymbol) uc336ohs.1 uc336ohs.1 
ENSMUST00000337460.1 ENSMUSG00000136745 ENSMUST00000337460.1 ENSMUSG00000136745 (from geneSymbol) uc336ohu.1 uc336ohu.1 
ENSMUST00000337466.1 ENSMUSG00000136746 ENSMUST00000337466.1 ENSMUSG00000136746 (from geneSymbol) uc336oia.1 uc336oia.1 
ENSMUST00000337467.1 ENSMUSG00000136747 ENSMUST00000337467.1 ENSMUSG00000136747 (from geneSymbol) uc336oib.1 uc336oib.1 
ENSMUST00000337468.1 ENSMUSG00000136748 ENSMUST00000337468.1 ENSMUSG00000136748 (from geneSymbol) uc336oic.1 uc336oic.1 
ENSMUST00000337469.1 ENSMUSG00000136749 ENSMUST00000337469.1 ENSMUSG00000136749 (from geneSymbol) uc336oid.1 uc336oid.1 
ENSMUST00000337470.1 ENSMUSG00000136750 ENSMUST00000337470.1 ENSMUSG00000136750 (from geneSymbol) AK147071 uc336oie.1 uc336oie.1 
ENSMUST00000337483.1 ENSMUSG00000136751 ENSMUST00000337483.1 ENSMUSG00000136751 (from geneSymbol) AK139225 uc336oir.1 uc336oir.1 
ENSMUST00000337484.1 ENSMUSG00000136752 ENSMUST00000337484.1 ENSMUSG00000136752 (from geneSymbol) uc336ois.1 uc336ois.1 
ENSMUST00000337485.1 ENSMUSG00000136753 ENSMUST00000337485.1 ENSMUSG00000136753 (from geneSymbol) uc336oit.1 uc336oit.1 
ENSMUST00000337487.1 ENSMUSG00000136754 ENSMUST00000337487.1 ENSMUSG00000136754 (from geneSymbol) uc336oiv.1 uc336oiv.1 
ENSMUST00000337538.1 ENSMUSG00000136755 ENSMUST00000337538.1 ENSMUSG00000136755 (from geneSymbol) uc336oku.1 uc336oku.1 
ENSMUST00000337544.1 ENSMUSG00000136756 ENSMUST00000337544.1 ENSMUSG00000136756 (from geneSymbol) uc336ola.1 uc336ola.1 
ENSMUST00000337545.1 ENSMUSG00000136757 ENSMUST00000337545.1 ENSMUSG00000136757 (from geneSymbol) uc336olb.1 uc336olb.1 
ENSMUST00000337552.1 ENSMUSG00000136758 ENSMUST00000337552.1 ENSMUSG00000136758 (from geneSymbol) uc336oli.1 uc336oli.1 
ENSMUST00000337553.1 ENSMUSG00000136759 ENSMUST00000337553.1 ENSMUSG00000136759 (from geneSymbol) uc336olj.1 uc336olj.1 
ENSMUST00000337554.1 ENSMUSG00000136760 ENSMUST00000337554.1 ENSMUSG00000136760 (from geneSymbol) uc336olk.1 uc336olk.1 
ENSMUST00000337556.1 ENSMUSG00000136761 ENSMUST00000337556.1 ENSMUSG00000136761 (from geneSymbol) uc336olm.1 uc336olm.1 
ENSMUST00000337557.1 ENSMUSG00000136762 ENSMUST00000337557.1 ENSMUSG00000136762 (from geneSymbol) uc336oln.1 uc336oln.1 
ENSMUST00000337558.1 ENSMUSG00000136763 ENSMUST00000337558.1 ENSMUSG00000136763 (from geneSymbol) uc336olo.1 uc336olo.1 
ENSMUST00000337563.1 ENSMUSG00000136764 ENSMUST00000337563.1 ENSMUSG00000136764 (from geneSymbol) uc336olt.1 uc336olt.1 
ENSMUST00000337565.1 ENSMUSG00000136765 ENSMUST00000337565.1 ENSMUSG00000136765 (from geneSymbol) uc336olv.1 uc336olv.1 
ENSMUST00000337567.1 ENSMUSG00000136766 ENSMUST00000337567.1 ENSMUSG00000136766 (from geneSymbol) uc336olx.1 uc336olx.1 
ENSMUST00000337569.1 ENSMUSG00000136767 ENSMUST00000337569.1 ENSMUSG00000136767 (from geneSymbol) uc336olz.1 uc336olz.1 
ENSMUST00000337570.1 Gm47152 ENSMUST00000337570.1 Gm47152 (from geneSymbol) uc336oma.1 uc336oma.1 
ENSMUST00000337572.1 ENSMUSG00000136768 ENSMUST00000337572.1 ENSMUSG00000136768 (from geneSymbol) uc336omc.1 uc336omc.1 
ENSMUST00000337574.1 ENSMUSG00000136769 ENSMUST00000337574.1 ENSMUSG00000136769 (from geneSymbol) uc336ome.1 uc336ome.1 
ENSMUST00000337582.1 ENSMUSG00000136770 ENSMUST00000337582.1 ENSMUSG00000136770 (from geneSymbol) uc336omm.1 uc336omm.1 
ENSMUST00000337584.1 ENSMUSG00000136771 ENSMUST00000337584.1 ENSMUSG00000136771 (from geneSymbol) uc336omo.1 uc336omo.1 
ENSMUST00000337586.1 ENSMUSG00000136772 ENSMUST00000337586.1 ENSMUSG00000136772 (from geneSymbol) uc336omq.1 uc336omq.1 
ENSMUST00000337588.1 ENSMUSG00000136774 ENSMUST00000337588.1 ENSMUSG00000136774 (from geneSymbol) uc336omr.1 uc336omr.1 
ENSMUST00000337589.1 ENSMUSG00000136775 ENSMUST00000337589.1 ENSMUSG00000136775 (from geneSymbol) uc336oms.1 uc336oms.1 
ENSMUST00000337591.1 ENSMUSG00000136776 ENSMUST00000337591.1 ENSMUSG00000136776 (from geneSymbol) uc336omu.1 uc336omu.1 
ENSMUST00000337592.1 ENSMUSG00000136777 ENSMUST00000337592.1 ENSMUSG00000136777 (from geneSymbol) uc336omv.1 uc336omv.1 
ENSMUST00000337593.1 ENSMUSG00000136778 ENSMUST00000337593.1 ENSMUSG00000136778 (from geneSymbol) uc336omw.1 uc336omw.1 
ENSMUST00000337594.1 ENSMUSG00000136779 ENSMUST00000337594.1 ENSMUSG00000136779 (from geneSymbol) uc336omx.1 uc336omx.1 
ENSMUST00000337595.1 ENSMUSG00000136780 ENSMUST00000337595.1 ENSMUSG00000136780 (from geneSymbol) uc336omy.1 uc336omy.1 
ENSMUST00000337596.1 ENSMUSG00000136781 ENSMUST00000337596.1 ENSMUSG00000136781 (from geneSymbol) uc336omz.1 uc336omz.1 
ENSMUST00000337599.1 ENSMUSG00000136782 ENSMUST00000337599.1 ENSMUSG00000136782 (from geneSymbol) uc336onc.1 uc336onc.1 
ENSMUST00000337603.1 ENSMUSG00000136783 ENSMUST00000337603.1 ENSMUSG00000136783 (from geneSymbol) uc336ong.1 uc336ong.1 
ENSMUST00000337604.1 ENSMUSG00000136784 ENSMUST00000337604.1 ENSMUSG00000136784 (from geneSymbol) uc336onh.1 uc336onh.1 
ENSMUST00000337605.1 ENSMUSG00000136785 ENSMUST00000337605.1 ENSMUSG00000136785 (from geneSymbol) KY467493 uc336oni.1 uc336oni.1 
ENSMUST00000337606.1 ENSMUSG00000136786 ENSMUST00000337606.1 ENSMUSG00000136786 (from geneSymbol) uc336onj.1 uc336onj.1 
ENSMUST00000337607.1 ENSMUSG00000136787 ENSMUST00000337607.1 ENSMUSG00000136787 (from geneSymbol) uc336onk.1 uc336onk.1 
ENSMUST00000337609.1 ENSMUSG00000136788 ENSMUST00000337609.1 ENSMUSG00000136788 (from geneSymbol) uc336onm.1 uc336onm.1 
ENSMUST00000337610.1 ENSMUSG00000136789 ENSMUST00000337610.1 ENSMUSG00000136789 (from geneSymbol) LF204224 uc336onn.1 uc336onn.1 
ENSMUST00000337612.1 ENSMUSG00000136791 ENSMUST00000337612.1 ENSMUSG00000136791 (from geneSymbol) uc336ono.1 uc336ono.1 
ENSMUST00000337613.1 ENSMUSG00000136792 ENSMUST00000337613.1 ENSMUSG00000136792 (from geneSymbol) uc336onp.1 uc336onp.1 
ENSMUST00000337617.1 4930429F11Rik ENSMUST00000337617.1 RIKEN cDNA 4930429F11 gene (from RefSeq NR_033463.1) NR_033463 uc336ont.1 uc336ont.1 
ENSMUST00000337619.1 ENSMUSG00000136794 ENSMUST00000337619.1 ENSMUSG00000136794 (from geneSymbol) uc336onv.1 uc336onv.1 
ENSMUST00000337620.1 Gm57096 ENSMUST00000337620.1 Gm57096 (from geneSymbol) uc336onw.1 uc336onw.1 
ENSMUST00000337641.1 ENSMUSG00000136795 ENSMUST00000337641.1 ENSMUSG00000136795 (from geneSymbol) uc336oor.1 uc336oor.1 
ENSMUST00000337642.1 ENSMUSG00000136796 ENSMUST00000337642.1 ENSMUSG00000136796 (from geneSymbol) uc336oos.1 uc336oos.1 
ENSMUST00000337666.1 ENSMUSG00000136797 ENSMUST00000337666.1 ENSMUSG00000136797 (from geneSymbol) uc336opq.1 uc336opq.1 
ENSMUST00000337667.1 ENSMUSG00000136798 ENSMUST00000337667.1 ENSMUSG00000136798 (from geneSymbol) uc336opr.1 uc336opr.1 
ENSMUST00000337668.1 1700061H18Rik ENSMUST00000337668.1 1700061H18Rik (from geneSymbol) AK006853 uc336ops.1 uc336ops.1 
ENSMUST00000337672.1 ENSMUSG00000136799 ENSMUST00000337672.1 ENSMUSG00000136799 (from geneSymbol) uc336opw.1 uc336opw.1 
ENSMUST00000337676.1 1700112H15Rik ENSMUST00000337676.1 1700112H15Rik (from geneSymbol) AK007177 uc336oqa.1 uc336oqa.1 
ENSMUST00000337677.1 ENSMUSG00000136800 ENSMUST00000337677.1 ENSMUSG00000136800 (from geneSymbol) LF195492 uc336oqb.1 uc336oqb.1 
ENSMUST00000337679.1 ENSMUSG00000136801 ENSMUST00000337679.1 ENSMUSG00000136801 (from geneSymbol) uc336oqd.1 uc336oqd.1 
ENSMUST00000337694.1 ENSMUSG00000136802 ENSMUST00000337694.1 ENSMUSG00000136802 (from geneSymbol) uc336oqs.1 uc336oqs.1 
ENSMUST00000337700.1 ENSMUSG00000121748 ENSMUST00000337700.1 ENSMUSG00000121748 (from geneSymbol) AK076693 uc336oqy.1 uc336oqy.1 
ENSMUST00000337703.1 ENSMUSG00000136803 ENSMUST00000337703.1 ENSMUSG00000136803 (from geneSymbol) uc336orb.1 uc336orb.1 
ENSMUST00000337705.1 Gm42468 ENSMUST00000337705.1 Gm42468 (from geneSymbol) uc336ord.1 uc336ord.1 
ENSMUST00000337706.1 Gm57303 ENSMUST00000337706.1 Gm57303 (from geneSymbol) uc336ore.1 uc336ore.1 
ENSMUST00000337707.1 ENSMUSG00000136804 ENSMUST00000337707.1 ENSMUSG00000136804 (from geneSymbol) uc336orf.1 uc336orf.1 
ENSMUST00000337708.1 ENSMUSG00000136805 ENSMUST00000337708.1 ENSMUSG00000136805 (from geneSymbol) uc336org.1 uc336org.1 
ENSMUST00000337709.1 Gm30786 ENSMUST00000337709.1 Gm30786 (from geneSymbol) uc336orh.1 uc336orh.1 
ENSMUST00000337725.1 ENSMUSG00000136806 ENSMUST00000337725.1 ENSMUSG00000136806 (from geneSymbol) uc336orx.1 uc336orx.1 
ENSMUST00000337727.1 Gm28382 ENSMUST00000337727.1 Gm28382 (from geneSymbol) AK031652 uc336ory.1 uc336ory.1 
ENSMUST00000337728.1 ENSMUSG00000136808 ENSMUST00000337728.1 ENSMUSG00000136808 (from geneSymbol) uc336orz.1 uc336orz.1 
ENSMUST00000337729.1 Gm16083 ENSMUST00000337729.1 Gm16083 (from geneSymbol) AK082696 uc336osa.1 uc336osa.1 
ENSMUST00000337750.1 ENSMUSG00000136809 ENSMUST00000337750.1 ENSMUSG00000136809 (from geneSymbol) uc336osv.1 uc336osv.1 
ENSMUST00000337754.1 ENSMUSG00000136810 ENSMUST00000337754.1 ENSMUSG00000136810 (from geneSymbol) uc336osz.1 uc336osz.1 
ENSMUST00000337755.1 ENSMUSG00000136811 ENSMUST00000337755.1 ENSMUSG00000136811 (from geneSymbol) uc336ota.1 uc336ota.1 
ENSMUST00000337756.1 ENSMUSG00000136812 ENSMUST00000337756.1 ENSMUSG00000136812 (from geneSymbol) uc336otb.1 uc336otb.1 
ENSMUST00000337757.1 ENSMUSG00000136813 ENSMUST00000337757.1 ENSMUSG00000136813 (from geneSymbol) uc336otc.1 uc336otc.1 
ENSMUST00000337759.1 Gm13012 ENSMUST00000337759.1 Gm13012 (from geneSymbol) KY468026 uc336ote.1 uc336ote.1 
ENSMUST00000337761.1 ENSMUSG00000136814 ENSMUST00000337761.1 ENSMUSG00000136814 (from geneSymbol) uc336otg.1 uc336otg.1 
ENSMUST00000337763.1 Gm47153 ENSMUST00000337763.1 Gm47153 (from geneSymbol) uc336oti.1 uc336oti.1 
ENSMUST00000337769.1 ENSMUSG00000136815 ENSMUST00000337769.1 ENSMUSG00000136815 (from geneSymbol) uc336oto.1 uc336oto.1 
ENSMUST00000337770.1 ENSMUSG00000136816 ENSMUST00000337770.1 ENSMUSG00000136816 (from geneSymbol) uc336otp.1 uc336otp.1 
ENSMUST00000337774.1 ENSMUSG00000136817 ENSMUST00000337774.1 ENSMUSG00000136817 (from geneSymbol) uc336ott.1 uc336ott.1 
ENSMUST00000337779.1 ENSMUSG00000136818 ENSMUST00000337779.1 ENSMUSG00000136818 (from geneSymbol) uc336oty.1 uc336oty.1 
ENSMUST00000337780.1 ENSMUSG00000136819 ENSMUST00000337780.1 ENSMUSG00000136819 (from geneSymbol) uc336otz.1 uc336otz.1 
ENSMUST00000337785.1 Gm13427 ENSMUST00000337785.1 Gm13427 (from geneSymbol) AK006784 uc336oue.1 uc336oue.1 
ENSMUST00000337792.1 ENSMUSG00000136820 ENSMUST00000337792.1 ENSMUSG00000136820 (from geneSymbol) uc336oul.1 uc336oul.1 
ENSMUST00000337796.1 4930515L03Rik ENSMUST00000337796.1 RIKEN cDNA 4930515L03 gene (from RefSeq NR_040632.1) NR_040632 uc336oup.1 uc336oup.1 
ENSMUST00000337802.1 ENSMUSG00000136822 ENSMUST00000337802.1 ENSMUSG00000136822 (from geneSymbol) uc336ouv.1 uc336ouv.1 
ENSMUST00000337803.1 ENSMUSG00000136823 ENSMUST00000337803.1 ENSMUSG00000136823 (from geneSymbol) uc336ouw.1 uc336ouw.1 
ENSMUST00000337804.1 ENSMUSG00000136824 ENSMUST00000337804.1 ENSMUSG00000136824 (from geneSymbol) uc336oux.1 uc336oux.1 
ENSMUST00000337805.1 ENSMUSG00000136825 ENSMUST00000337805.1 ENSMUSG00000136825 (from geneSymbol) uc336ouy.1 uc336ouy.1 
ENSMUST00000337808.1 ENSMUSG00000136826 ENSMUST00000337808.1 ENSMUSG00000136826 (from geneSymbol) uc336ovb.1 uc336ovb.1 
ENSMUST00000337809.1 ENSMUSG00000136827 ENSMUST00000337809.1 ENSMUSG00000136827 (from geneSymbol) uc336ovc.1 uc336ovc.1 
ENSMUST00000337810.1 ENSMUSG00000136828 ENSMUST00000337810.1 ENSMUSG00000136828 (from geneSymbol) uc336ovd.1 uc336ovd.1 
ENSMUST00000337811.1 ENSMUSG00000136829 ENSMUST00000337811.1 ENSMUSG00000136829 (from geneSymbol) uc336ove.1 uc336ove.1 
ENSMUST00000337819.1 ENSMUSG00000136830 ENSMUST00000337819.1 ENSMUSG00000136830 (from geneSymbol) uc336ovm.1 uc336ovm.1 
ENSMUST00000337820.1 ENSMUSG00000136831 ENSMUST00000337820.1 ENSMUSG00000136831 (from geneSymbol) uc336ovn.1 uc336ovn.1 
ENSMUST00000337821.1 ENSMUSG00000136832 ENSMUST00000337821.1 ENSMUSG00000136832 (from geneSymbol) uc336ovo.1 uc336ovo.1 
ENSMUST00000337822.1 ENSMUSG00000136833 ENSMUST00000337822.1 ENSMUSG00000136833 (from geneSymbol) uc336ovp.1 uc336ovp.1 
ENSMUST00000337824.1 1700025O08Rik ENSMUST00000337824.1 1700025O08Rik (from geneSymbol) AK006362 uc336ovr.1 uc336ovr.1 
ENSMUST00000337828.1 ENSMUSG00000136834 ENSMUST00000337828.1 ENSMUSG00000136834 (from geneSymbol) uc336ovv.1 uc336ovv.1 
ENSMUST00000337839.1 ENSMUSG00000136835 ENSMUST00000337839.1 ENSMUSG00000136835 (from geneSymbol) uc336owg.1 uc336owg.1 
ENSMUST00000337841.1 ENSMUSG00000136836 ENSMUST00000337841.1 ENSMUSG00000136836 (from geneSymbol) uc336owi.1 uc336owi.1 
ENSMUST00000337843.1 ENSMUSG00000136837 ENSMUST00000337843.1 ENSMUSG00000136837 (from geneSymbol) uc336owk.1 uc336owk.1 
ENSMUST00000337845.1 ENSMUSG00000136838 ENSMUST00000337845.1 ENSMUSG00000136838 (from geneSymbol) uc336owm.1 uc336owm.1 
ENSMUST00000337846.1 ENSMUSG00000136839 ENSMUST00000337846.1 ENSMUSG00000136839 (from geneSymbol) uc336own.1 uc336own.1 
ENSMUST00000337847.1 ENSMUSG00000136840 ENSMUST00000337847.1 ENSMUSG00000136840 (from geneSymbol) uc336owo.1 uc336owo.1 
ENSMUST00000337848.1 ENSMUSG00000136841 ENSMUST00000337848.1 ENSMUSG00000136841 (from geneSymbol) uc336owp.1 uc336owp.1 
ENSMUST00000337849.1 ENSMUSG00000136842 ENSMUST00000337849.1 ENSMUSG00000136842 (from geneSymbol) uc336owq.1 uc336owq.1 
ENSMUST00000337852.1 ENSMUSG00000136843 ENSMUST00000337852.1 ENSMUSG00000136843 (from geneSymbol) uc336owt.1 uc336owt.1 
ENSMUST00000337856.1 ENSMUSG00000136844 ENSMUST00000337856.1 ENSMUSG00000136844 (from geneSymbol) uc336owx.1 uc336owx.1 
ENSMUST00000337863.1 ENSMUSG00000136845 ENSMUST00000337863.1 ENSMUSG00000136845 (from geneSymbol) uc336oxe.1 uc336oxe.1 
ENSMUST00000337864.1 ENSMUSG00000136846 ENSMUST00000337864.1 ENSMUSG00000136846 (from geneSymbol) uc336oxf.1 uc336oxf.1 
ENSMUST00000337872.1 4930429C20Rik ENSMUST00000337872.1 4930429C20Rik (from geneSymbol) AK015232 uc336oxn.1 uc336oxn.1 
ENSMUST00000337881.1 Gm14092 ENSMUST00000337881.1 Gm14092 (from geneSymbol) AK133124 uc336oxw.1 uc336oxw.1 
ENSMUST00000337882.1 ENSMUSG00000136847 ENSMUST00000337882.1 ENSMUSG00000136847 (from geneSymbol) uc336oxx.1 uc336oxx.1 
ENSMUST00000337883.1 ENSMUSG00000136848 ENSMUST00000337883.1 ENSMUSG00000136848 (from geneSymbol) uc336oxy.1 uc336oxy.1 
ENSMUST00000337884.1 ENSMUSG00000136849 ENSMUST00000337884.1 ENSMUSG00000136849 (from geneSymbol) uc336oxz.1 uc336oxz.1 
ENSMUST00000337885.1 Gm28707 ENSMUST00000337885.1 Gm28707 (from geneSymbol) uc336oya.1 uc336oya.1 
ENSMUST00000337888.1 ENSMUSG00000136850 ENSMUST00000337888.1 ENSMUSG00000136850 (from geneSymbol) uc336oyd.1 uc336oyd.1 
ENSMUST00000337891.1 ENSMUSG00000136851 ENSMUST00000337891.1 ENSMUSG00000136851 (from geneSymbol) uc336oyg.1 uc336oyg.1 
ENSMUST00000337892.1 ENSMUSG00000136852 ENSMUST00000337892.1 ENSMUSG00000136852 (from geneSymbol) uc336oyh.1 uc336oyh.1 
ENSMUST00000337893.1 Gm6653 ENSMUST00000337893.1 predicted gene 6653 (from RefSeq NR_169022.1) NR_169022 uc336oyi.1 uc336oyi.1 
ENSMUST00000337894.1 ENSMUSG00000136854 ENSMUST00000337894.1 ENSMUSG00000136854 (from geneSymbol) uc336oyj.1 uc336oyj.1 
ENSMUST00000337895.1 ENSMUSG00000136855 ENSMUST00000337895.1 ENSMUSG00000136855 (from geneSymbol) uc336oyk.1 uc336oyk.1 
ENSMUST00000337899.1 ENSMUSG00000136856 ENSMUST00000337899.1 ENSMUSG00000136856 (from geneSymbol) uc336oyo.1 uc336oyo.1 
ENSMUST00000337901.1 ENSMUSG00000136857 ENSMUST00000337901.1 ENSMUSG00000136857 (from geneSymbol) uc336oyq.1 uc336oyq.1 
ENSMUST00000337903.1 ENSMUSG00000136858 ENSMUST00000337903.1 ENSMUSG00000136858 (from geneSymbol) uc336oys.1 uc336oys.1 
ENSMUST00000337912.1 Gm48071 ENSMUST00000337912.1 Gm48071 (from geneSymbol) uc336oza.1 uc336oza.1 
ENSMUST00000337935.1 ENSMUSG00000136861 ENSMUST00000337935.1 ENSMUSG00000136861 (from geneSymbol) uc336ozt.1 uc336ozt.1 
ENSMUST00000337938.1 ENSMUSG00000136862 ENSMUST00000337938.1 ENSMUSG00000136862 (from geneSymbol) AK015970 uc336ozw.1 uc336ozw.1 
ENSMUST00000337943.1 ENSMUSG00000136863 ENSMUST00000337943.1 ENSMUSG00000136863 (from geneSymbol) uc336pab.1 uc336pab.1 
ENSMUST00000337946.1 ENSMUSG00000136864 ENSMUST00000337946.1 ENSMUSG00000136864 (from geneSymbol) uc336pae.1 uc336pae.1 
ENSMUST00000337949.1 Gm16098 ENSMUST00000337949.1 Gm16098 (from geneSymbol) uc336pah.1 uc336pah.1 
ENSMUST00000337959.1 ENSMUSG00000136865 ENSMUST00000337959.1 ENSMUSG00000136865 (from geneSymbol) uc336par.1 uc336par.1 
ENSMUST00000337966.1 ENSMUSG00000136866 ENSMUST00000337966.1 ENSMUSG00000136866 (from geneSymbol) uc336pay.1 uc336pay.1 
ENSMUST00000337968.1 Gm31728 ENSMUST00000337968.1 Gm31728 (from geneSymbol) uc336pba.1 uc336pba.1 
ENSMUST00000337983.1 ENSMUSG00000136867 ENSMUST00000337983.1 ENSMUSG00000136867 (from geneSymbol) uc336pbp.1 uc336pbp.1 
ENSMUST00000337985.1 ENSMUSG00000136868 ENSMUST00000337985.1 ENSMUSG00000136868 (from geneSymbol) uc336pbr.1 uc336pbr.1 
ENSMUST00000337986.1 ENSMUSG00000136869 ENSMUST00000337986.1 ENSMUSG00000136869 (from geneSymbol) uc336pbs.1 uc336pbs.1 
ENSMUST00000337987.1 ENSMUSG00000136870 ENSMUST00000337987.1 ENSMUSG00000136870 (from geneSymbol) uc336pbt.1 uc336pbt.1 
ENSMUST00000337989.1 ENSMUSG00000136871 ENSMUST00000337989.1 ENSMUSG00000136871 (from geneSymbol) uc336pbv.1 uc336pbv.1 
ENSMUST00000337992.1 ENSMUSG00000136872 ENSMUST00000337992.1 ENSMUSG00000136872 (from geneSymbol) uc336pby.1 uc336pby.1 
ENSMUST00000337993.1 ENSMUSG00000136873 ENSMUST00000337993.1 ENSMUSG00000136873 (from geneSymbol) uc336pbz.1 uc336pbz.1 
ENSMUST00000337994.1 ENSMUSG00000136874 ENSMUST00000337994.1 ENSMUSG00000136874 (from geneSymbol) uc336pca.1 uc336pca.1 
ENSMUST00000337996.1 ENSMUSG00000136875 ENSMUST00000337996.1 ENSMUSG00000136875 (from geneSymbol) uc336pcc.1 uc336pcc.1 
ENSMUST00000337997.1 ENSMUSG00000136876 ENSMUST00000337997.1 ENSMUSG00000136876 (from geneSymbol) uc336pcd.1 uc336pcd.1 
ENSMUST00000337998.1 ENSMUSG00000136877 ENSMUST00000337998.1 ENSMUSG00000136877 (from geneSymbol) uc336pce.1 uc336pce.1 
ENSMUST00000338000.1 ENSMUSG00000136878 ENSMUST00000338000.1 ENSMUSG00000136878 (from geneSymbol) uc336pcg.1 uc336pcg.1 
ENSMUST00000338004.1 ENSMUSG00000136879 ENSMUST00000338004.1 ENSMUSG00000136879 (from geneSymbol) uc336pck.1 uc336pck.1 
ENSMUST00000338005.1 ENSMUSG00000136880 ENSMUST00000338005.1 ENSMUSG00000136880 (from geneSymbol) uc336pcl.1 uc336pcl.1 
ENSMUST00000338008.1 ENSMUSG00000136881 ENSMUST00000338008.1 ENSMUSG00000136881 (from geneSymbol) uc336pco.1 uc336pco.1 
ENSMUST00000338009.1 ENSMUSG00000136882 ENSMUST00000338009.1 ENSMUSG00000136882 (from geneSymbol) uc336pcp.1 uc336pcp.1 
ENSMUST00000338020.1 ENSMUSG00000136883 ENSMUST00000338020.1 ENSMUSG00000136883 (from geneSymbol) uc336pda.1 uc336pda.1 
ENSMUST00000338021.1 1700057H15Rik ENSMUST00000338021.1 1700057H15Rik (from geneSymbol) AK132134 uc336pdb.1 uc336pdb.1 
ENSMUST00000338037.1 ENSMUSG00000136884 ENSMUST00000338037.1 ENSMUSG00000136884 (from geneSymbol) uc336pdr.1 uc336pdr.1 
ENSMUST00000338038.1 ENSMUSG00000136885 ENSMUST00000338038.1 ENSMUSG00000136885 (from geneSymbol) uc336pds.1 uc336pds.1 
ENSMUST00000338039.1 ENSMUSG00000136886 ENSMUST00000338039.1 ENSMUSG00000136886 (from geneSymbol) uc336pdt.1 uc336pdt.1 
ENSMUST00000338040.1 ENSMUSG00000136887 ENSMUST00000338040.1 ENSMUSG00000136887 (from geneSymbol) uc336pdu.1 uc336pdu.1 
ENSMUST00000338043.1 Gm50114 ENSMUST00000338043.1 Gm50114 (from geneSymbol) uc336pdx.1 uc336pdx.1 
ENSMUST00000338048.1 ENSMUSG00000136888 ENSMUST00000338048.1 ENSMUSG00000136888 (from geneSymbol) uc336pec.1 uc336pec.1 
ENSMUST00000338051.1 ENSMUSG00000136889 ENSMUST00000338051.1 ENSMUSG00000136889 (from geneSymbol) uc336pef.1 uc336pef.1 
ENSMUST00000338052.1 ENSMUSG00000136890 ENSMUST00000338052.1 ENSMUSG00000136890 (from geneSymbol) uc336peg.1 uc336peg.1 
ENSMUST00000338053.1 ENSMUSG00000136891 ENSMUST00000338053.1 ENSMUSG00000136891 (from geneSymbol) uc336peh.1 uc336peh.1 
ENSMUST00000338054.1 ENSMUSG00000136892 ENSMUST00000338054.1 ENSMUSG00000136892 (from geneSymbol) LF194898 uc336pei.1 uc336pei.1 
ENSMUST00000338055.1 ENSMUSG00000136893 ENSMUST00000338055.1 ENSMUSG00000136893 (from geneSymbol) uc336pej.1 uc336pej.1 
ENSMUST00000338058.1 ENSMUSG00000136894 ENSMUST00000338058.1 ENSMUSG00000136894 (from geneSymbol) uc336pem.1 uc336pem.1 
ENSMUST00000338060.1 ENSMUSG00000136895 ENSMUST00000338060.1 ENSMUSG00000136895 (from geneSymbol) uc336peo.1 uc336peo.1 
ENSMUST00000338063.1 4833417C18Rik ENSMUST00000338063.1 4833417C18Rik (from geneSymbol) AK133925 uc336per.1 uc336per.1 
ENSMUST00000338072.1 Gm47069 ENSMUST00000338072.1 Gm47069 (from geneSymbol) uc336pfa.1 uc336pfa.1 
ENSMUST00000338075.1 Gm20868 ENSMUST00000338075.1 Gm20868 (from geneSymbol) AK006494 uc336pfd.1 uc336pfd.1 
ENSMUST00000338076.1 ENSMUSG00000136897 ENSMUST00000338076.1 ENSMUSG00000136897 (from geneSymbol) uc336pfe.1 uc336pfe.1 
ENSMUST00000338079.1 ENSMUSG00000136898 ENSMUST00000338079.1 ENSMUSG00000136898 (from geneSymbol) uc336pfh.1 uc336pfh.1 
ENSMUST00000338080.1 ENSMUSG00000136899 ENSMUST00000338080.1 ENSMUSG00000136899 (from geneSymbol) uc336pfi.1 uc336pfi.1 
ENSMUST00000338085.1 ENSMUSG00000136900 ENSMUST00000338085.1 ENSMUSG00000136900 (from geneSymbol) uc336pfn.1 uc336pfn.1 
ENSMUST00000338086.1 ENSMUSG00000136901 ENSMUST00000338086.1 ENSMUSG00000136901 (from geneSymbol) uc336pfo.1 uc336pfo.1 
ENSMUST00000338087.1 ENSMUSG00000136902 ENSMUST00000338087.1 ENSMUSG00000136902 (from geneSymbol) uc336pfp.1 uc336pfp.1 
ENSMUST00000338089.1 ENSMUSG00000136903 ENSMUST00000338089.1 ENSMUSG00000136903 (from geneSymbol) uc336pfr.1 uc336pfr.1 
ENSMUST00000338106.1 ENSMUSG00000136904 ENSMUST00000338106.1 ENSMUSG00000136904 (from geneSymbol) uc336pgi.1 uc336pgi.1 
ENSMUST00000338109.1 ENSMUSG00000136905 ENSMUST00000338109.1 ENSMUSG00000136905 (from geneSymbol) uc336pgl.1 uc336pgl.1 
ENSMUST00000338113.1 ENSMUSG00000136906 ENSMUST00000338113.1 ENSMUSG00000136906 (from geneSymbol) uc336pgp.1 uc336pgp.1 
ENSMUST00000338114.1 ENSMUSG00000136907 ENSMUST00000338114.1 ENSMUSG00000136907 (from geneSymbol) uc336pgq.1 uc336pgq.1 
ENSMUST00000338115.1 ENSMUSG00000136908 ENSMUST00000338115.1 ENSMUSG00000136908 (from geneSymbol) uc336pgr.1 uc336pgr.1 
ENSMUST00000338121.1 ENSMUSG00000136910 ENSMUST00000338121.1 ENSMUSG00000136910 (from geneSymbol) uc336pgw.1 uc336pgw.1 
ENSMUST00000338126.1 Gm3519 ENSMUST00000338126.1 Gm3519 (from geneSymbol) AK139157 uc336phb.1 uc336phb.1 
ENSMUST00000338127.1 ENSMUSG00000136911 ENSMUST00000338127.1 ENSMUSG00000136911 (from geneSymbol) LF193670 uc336phc.1 uc336phc.1 
ENSMUST00000338128.1 ENSMUSG00000136912 ENSMUST00000338128.1 ENSMUSG00000136912 (from geneSymbol) uc336phd.1 uc336phd.1 
ENSMUST00000338129.1 ENSMUSG00000136913 ENSMUST00000338129.1 ENSMUSG00000136913 (from geneSymbol) uc336phe.1 uc336phe.1 
ENSMUST00000338130.1 ENSMUSG00000136914 ENSMUST00000338130.1 ENSMUSG00000136914 (from geneSymbol) uc336phf.1 uc336phf.1 
ENSMUST00000338131.1 ENSMUSG00000136915 ENSMUST00000338131.1 ENSMUSG00000136915 (from geneSymbol) uc336phg.1 uc336phg.1 
ENSMUST00000338132.1 ENSMUSG00000136916 ENSMUST00000338132.1 ENSMUSG00000136916 (from geneSymbol) uc336phh.1 uc336phh.1 
ENSMUST00000338134.1 ENSMUSG00000136917 ENSMUST00000338134.1 ENSMUSG00000136917 (from geneSymbol) uc336phj.1 uc336phj.1 
ENSMUST00000338137.1 ENSMUSG00000136918 ENSMUST00000338137.1 ENSMUSG00000136918 (from geneSymbol) uc336phm.1 uc336phm.1 
ENSMUST00000338163.1 ENSMUSG00000136919 ENSMUST00000338163.1 ENSMUSG00000136919 (from geneSymbol) uc336pim.1 uc336pim.1 
ENSMUST00000338166.1 Gm34756 ENSMUST00000338166.1 Gm34756 (from geneSymbol) uc336pip.1 uc336pip.1 
ENSMUST00000338177.1 ENSMUSG00000136920 ENSMUST00000338177.1 ENSMUSG00000136920 (from geneSymbol) uc336pja.1 uc336pja.1 
ENSMUST00000338183.1 ENSMUSG00000136921 ENSMUST00000338183.1 ENSMUSG00000136921 (from geneSymbol) uc336pjg.1 uc336pjg.1 
ENSMUST00000338187.1 ENSMUSG00000136922 ENSMUST00000338187.1 ENSMUSG00000136922 (from geneSymbol) uc336pjk.1 uc336pjk.1 
ENSMUST00000338189.1 ENSMUSG00000136923 ENSMUST00000338189.1 ENSMUSG00000136923 (from geneSymbol) uc336pjm.1 uc336pjm.1 
ENSMUST00000338197.1 ENSMUSG00000136924 ENSMUST00000338197.1 ENSMUSG00000136924 (from geneSymbol) uc336pju.1 uc336pju.1 
ENSMUST00000338200.1 ENSMUSG00000136925 ENSMUST00000338200.1 ENSMUSG00000136925 (from geneSymbol) uc336pjx.1 uc336pjx.1 
ENSMUST00000338201.1 ENSMUSG00000136926 ENSMUST00000338201.1 ENSMUSG00000136926 (from geneSymbol) uc336pjy.1 uc336pjy.1 
ENSMUST00000338202.1 ENSMUSG00000136927 ENSMUST00000338202.1 ENSMUSG00000136927 (from geneSymbol) uc336pjz.1 uc336pjz.1 
ENSMUST00000338204.1 ENSMUSG00000136928 ENSMUST00000338204.1 ENSMUSG00000136928 (from geneSymbol) uc336pkb.1 uc336pkb.1 
ENSMUST00000338205.1 ENSMUSG00000136929 ENSMUST00000338205.1 ENSMUSG00000136929 (from geneSymbol) uc336pkc.1 uc336pkc.1 
ENSMUST00000338206.1 Gm11240 ENSMUST00000338206.1 Gm11240 (from geneSymbol) EU233991 uc336pkd.1 uc336pkd.1 
ENSMUST00000338237.1 ENSMUSG00000136930 ENSMUST00000338237.1 ENSMUSG00000136930 (from geneSymbol) uc336pli.1 uc336pli.1 
ENSMUST00000338238.1 ENSMUSG00000136931 ENSMUST00000338238.1 ENSMUSG00000136931 (from geneSymbol) uc336plj.1 uc336plj.1 
ENSMUST00000338240.1 Gm49709 ENSMUST00000338240.1 Gm49709 (from geneSymbol) uc336pll.1 uc336pll.1 
ENSMUST00000338252.1 ENSMUSG00000136932 ENSMUST00000338252.1 ENSMUSG00000136932 (from geneSymbol) uc336plx.1 uc336plx.1 
ENSMUST00000338254.1 Gm11527 ENSMUST00000338254.1 Gm11527 (from geneSymbol) uc336plz.1 uc336plz.1 
ENSMUST00000338261.1 ENSMUSG00000136933 ENSMUST00000338261.1 ENSMUSG00000136933 (from geneSymbol) uc336pmg.1 uc336pmg.1 
ENSMUST00000338267.1 1110028F18Rik ENSMUST00000338267.1 1110028F18Rik (from geneSymbol) AK003944 uc336pmm.1 uc336pmm.1 
ENSMUST00000338289.1 ENSMUSG00000136934 ENSMUST00000338289.1 ENSMUSG00000136934 (from geneSymbol) uc336pnh.1 uc336pnh.1 
ENSMUST00000338290.1 ENSMUSG00000136935 ENSMUST00000338290.1 ENSMUSG00000136935 (from geneSymbol) uc336pni.1 uc336pni.1 
ENSMUST00000338291.1 ENSMUSG00000136936 ENSMUST00000338291.1 ENSMUSG00000136936 (from geneSymbol) uc336pnj.1 uc336pnj.1 
ENSMUST00000338292.1 ENSMUSG00000136937 ENSMUST00000338292.1 ENSMUSG00000136937 (from geneSymbol) uc336pnk.1 uc336pnk.1 
ENSMUST00000338297.1 Gm48664 ENSMUST00000338297.1 Gm48664 (from geneSymbol) AK006652 uc336pnp.1 uc336pnp.1 
ENSMUST00000338309.1 Gm32090 ENSMUST00000338309.1 Gm32090 (from geneSymbol) AK133395 uc336pob.1 uc336pob.1 
ENSMUST00000338322.1 ENSMUSG00000136938 ENSMUST00000338322.1 ENSMUSG00000136938 (from geneSymbol) uc336poo.1 uc336poo.1 
ENSMUST00000338325.1 ENSMUSG00000136939 ENSMUST00000338325.1 ENSMUSG00000136939 (from geneSymbol) uc336por.1 uc336por.1 
ENSMUST00000338326.1 ENSMUSG00000136940 ENSMUST00000338326.1 ENSMUSG00000136940 (from geneSymbol) uc336pos.1 uc336pos.1 
ENSMUST00000338329.1 ENSMUSG00000136941 ENSMUST00000338329.1 ENSMUSG00000136941 (from geneSymbol) uc336pov.1 uc336pov.1 
ENSMUST00000338405.1 Gm49126 ENSMUST00000338405.1 Gm49126 (from geneSymbol) uc336prq.1 uc336prq.1 
ENSMUST00000338414.1 ENSMUSG00000136942 ENSMUST00000338414.1 ENSMUSG00000136942 (from geneSymbol) uc336prz.1 uc336prz.1 
ENSMUST00000338415.1 A830035A12Rik ENSMUST00000338415.1 A830035A12Rik (from geneSymbol) AK043804 uc336psa.1 uc336psa.1 
ENSMUST00000338432.1 ENSMUSG00000136943 ENSMUST00000338432.1 ENSMUSG00000136943 (from geneSymbol) uc336psr.1 uc336psr.1 
ENSMUST00000338434.1 ENSMUSG00000136944 ENSMUST00000338434.1 ENSMUSG00000136944 (from geneSymbol) uc336pst.1 uc336pst.1 
ENSMUST00000338436.1 ENSMUSG00000136945 ENSMUST00000338436.1 ENSMUSG00000136945 (from geneSymbol) uc336psv.1 uc336psv.1 
ENSMUST00000338439.1 ENSMUSG00000136946 ENSMUST00000338439.1 ENSMUSG00000136946 (from geneSymbol) uc336psy.1 uc336psy.1 
ENSMUST00000338440.1 ENSMUSG00000136947 ENSMUST00000338440.1 ENSMUSG00000136947 (from geneSymbol) LF243497 uc336psz.1 uc336psz.1 
ENSMUST00000338441.1 ENSMUSG00000136948 ENSMUST00000338441.1 ENSMUSG00000136948 (from geneSymbol) uc336pta.1 uc336pta.1 
ENSMUST00000338442.1 ENSMUSG00000136949 ENSMUST00000338442.1 ENSMUSG00000136949 (from geneSymbol) uc336ptb.1 uc336ptb.1 
ENSMUST00000338455.1 ENSMUSG00000136950 ENSMUST00000338455.1 ENSMUSG00000136950 (from geneSymbol) uc336pto.1 uc336pto.1 
ENSMUST00000338461.1 Gm42356 ENSMUST00000338461.1 predicted gene, 42356 (from RefSeq NR_168525.1) NR_168525 uc336ptu.1 uc336ptu.1 
ENSMUST00000338468.1 ENSMUSG00000136952 ENSMUST00000338468.1 ENSMUSG00000136952 (from geneSymbol) uc336pub.1 uc336pub.1 
ENSMUST00000338470.1 ENSMUSG00000136953 ENSMUST00000338470.1 ENSMUSG00000136953 (from geneSymbol) KY468201 uc336pud.1 uc336pud.1 
ENSMUST00000338471.1 ENSMUSG00000136954 ENSMUST00000338471.1 ENSMUSG00000136954 (from geneSymbol) uc336pue.1 uc336pue.1 
ENSMUST00000338473.1 ENSMUSG00000136955 ENSMUST00000338473.1 ENSMUSG00000136955 (from geneSymbol) uc336pug.1 uc336pug.1 
ENSMUST00000338475.1 ENSMUSG00000136956 ENSMUST00000338475.1 ENSMUSG00000136956 (from geneSymbol) uc336pui.1 uc336pui.1 
ENSMUST00000338477.1 ENSMUSG00000136957 ENSMUST00000338477.1 ENSMUSG00000136957 (from geneSymbol) uc336puk.1 uc336puk.1 
ENSMUST00000338478.1 ENSMUSG00000136958 ENSMUST00000338478.1 ENSMUSG00000136958 (from geneSymbol) uc336pul.1 uc336pul.1 
ENSMUST00000338480.1 ENSMUSG00000136959 ENSMUST00000338480.1 ENSMUSG00000136959 (from geneSymbol) uc336pun.1 uc336pun.1 
ENSMUST00000338493.1 ENSMUSG00000136960 ENSMUST00000338493.1 ENSMUSG00000136960 (from geneSymbol) uc336pva.1 uc336pva.1 
ENSMUST00000338494.1 ENSMUSG00000136961 ENSMUST00000338494.1 ENSMUSG00000136961 (from geneSymbol) uc336pvb.1 uc336pvb.1 
ENSMUST00000338495.1 ENSMUSG00000136962 ENSMUST00000338495.1 ENSMUSG00000136962 (from geneSymbol) uc336pvc.1 uc336pvc.1 
ENSMUST00000338497.1 ENSMUSG00000136963 ENSMUST00000338497.1 ENSMUSG00000136963 (from geneSymbol) uc336pve.1 uc336pve.1 
ENSMUST00000338498.1 ENSMUSG00000136964 ENSMUST00000338498.1 ENSMUSG00000136964 (from geneSymbol) LF194898 uc336pvf.1 uc336pvf.1 
ENSMUST00000338501.1 ENSMUSG00000136965 ENSMUST00000338501.1 ENSMUSG00000136965 (from geneSymbol) uc336pvi.1 uc336pvi.1 
ENSMUST00000338504.1 Gm49708 ENSMUST00000338504.1 Gm49708 (from geneSymbol) uc336pvl.1 uc336pvl.1 
ENSMUST00000338509.1 4930571N24Rik ENSMUST00000338509.1 4930571N24Rik (from geneSymbol) AK019804 uc336pvq.1 uc336pvq.1 
ENSMUST00000338521.1 4930420G21Rik ENSMUST00000338521.1 4930420G21Rik (from geneSymbol) AK054212 uc336pwc.1 uc336pwc.1 
ENSMUST00000338527.1 Gm15017 ENSMUST00000338527.1 Gm15017 (from geneSymbol) uc336pwf.1 uc336pwf.1 
ENSMUST00000338546.1 Gm33531 ENSMUST00000338546.1 Gm33531 (from geneSymbol) uc336pwy.1 uc336pwy.1 
ENSMUST00000338554.1 ENSMUSG00000136968 ENSMUST00000338554.1 ENSMUSG00000136968 (from geneSymbol) uc336pxg.1 uc336pxg.1 
ENSMUST00000338563.1 ENSMUSG00000136969 ENSMUST00000338563.1 ENSMUSG00000136969 (from geneSymbol) uc336pxp.1 uc336pxp.1 
ENSMUST00000338576.1 ENSMUSG00000136970 ENSMUST00000338576.1 ENSMUSG00000136970 (from geneSymbol) AK085543 uc336pyc.1 uc336pyc.1 
ENSMUST00000338597.1 ENSMUSG00000136971 ENSMUST00000338597.1 ENSMUSG00000136971 (from geneSymbol) uc336pyw.1 uc336pyw.1 
ENSMUST00000338600.1 ENSMUSG00000136972 ENSMUST00000338600.1 ENSMUSG00000136972 (from geneSymbol) uc336pyz.1 uc336pyz.1 
ENSMUST00000338605.1 ENSMUSG00000136973 ENSMUST00000338605.1 ENSMUSG00000136973 (from geneSymbol) uc336pze.1 uc336pze.1 
ENSMUST00000338606.1 ENSMUSG00000136974 ENSMUST00000338606.1 ENSMUSG00000136974 (from geneSymbol) uc336pzf.1 uc336pzf.1 
ENSMUST00000338609.1 1700045H11Rik ENSMUST00000338609.1 1700045H11Rik (from geneSymbol) AK006698 uc336pzi.1 uc336pzi.1 
ENSMUST00000338618.1 ENSMUSG00000136975 ENSMUST00000338618.1 ENSMUSG00000136975 (from geneSymbol) uc336pzr.1 uc336pzr.1 
ENSMUST00000338619.1 ENSMUSG00000136976 ENSMUST00000338619.1 ENSMUSG00000136976 (from geneSymbol) uc336pzs.1 uc336pzs.1 
ENSMUST00000338621.1 Gm41818 ENSMUST00000338621.1 Gm41818 (from geneSymbol) AK019726 uc336pzu.1 uc336pzu.1 
ENSMUST00000338629.1 1700024N05Rik ENSMUST00000338629.1 RIKEN cDNA 1700024N05 gene, transcript variant 1 (from RefSeq NR_126471.1) NR_126471 uc336qac.1 uc336qac.1 
ENSMUST00000338632.1 ENSMUSG00000136978 ENSMUST00000338632.1 ENSMUSG00000136978 (from geneSymbol) uc336qaf.1 uc336qaf.1 
ENSMUST00000338634.1 Gm57408 ENSMUST00000338634.1 Gm57408 (from geneSymbol) uc336qah.1 uc336qah.1 
ENSMUST00000338637.1 ENSMUSG00000136979 ENSMUST00000338637.1 ENSMUSG00000136979 (from geneSymbol) uc336qak.1 uc336qak.1 
ENSMUST00000338638.1 Gm26533 ENSMUST00000338638.1 Gm26533 (from geneSymbol) AK041287 uc336qal.1 uc336qal.1 
ENSMUST00000338640.1 ENSMUSG00000136980 ENSMUST00000338640.1 ENSMUSG00000136980 (from geneSymbol) uc336qan.1 uc336qan.1 
ENSMUST00000338642.1 ENSMUSG00000136981 ENSMUST00000338642.1 ENSMUSG00000136981 (from geneSymbol) uc336qap.1 uc336qap.1 
ENSMUST00000338643.1 Gm16160 ENSMUST00000338643.1 Gm16160 (from geneSymbol) uc336qaq.1 uc336qaq.1 
ENSMUST00000338646.1 ENSMUSG00000136982 ENSMUST00000338646.1 ENSMUSG00000136982 (from geneSymbol) uc336qat.1 uc336qat.1 
ENSMUST00000338648.1 ENSMUSG00000136983 ENSMUST00000338648.1 ENSMUSG00000136983 (from geneSymbol) LF194059 uc336qav.1 uc336qav.1 
ENSMUST00000338649.1 ENSMUSG00000136984 ENSMUST00000338649.1 ENSMUSG00000136984 (from geneSymbol) uc336qaw.1 uc336qaw.1 
ENSMUST00000338650.1 ENSMUSG00000136985 ENSMUST00000338650.1 ENSMUSG00000136985 (from geneSymbol) uc336qax.1 uc336qax.1 
ENSMUST00000338654.1 ENSMUSG00000136986 ENSMUST00000338654.1 ENSMUSG00000136986 (from geneSymbol) uc336qbb.1 uc336qbb.1 
ENSMUST00000338660.1 ENSMUSG00000136987 ENSMUST00000338660.1 ENSMUSG00000136987 (from geneSymbol) uc336qbh.1 uc336qbh.1 
ENSMUST00000338662.1 ENSMUSG00000136988 ENSMUST00000338662.1 ENSMUSG00000136988 (from geneSymbol) uc336qbj.1 uc336qbj.1 
ENSMUST00000338663.1 ENSMUSG00000136989 ENSMUST00000338663.1 ENSMUSG00000136989 (from geneSymbol) uc336qbk.1 uc336qbk.1 
ENSMUST00000338665.1 ENSMUSG00000136990 ENSMUST00000338665.1 ENSMUSG00000136990 (from geneSymbol) uc336qbm.1 uc336qbm.1 
ENSMUST00000338666.1 ENSMUSG00000136991 ENSMUST00000338666.1 ENSMUSG00000136991 (from geneSymbol) uc336qbn.1 uc336qbn.1 
ENSMUST00000338667.1 ENSMUSG00000136992 ENSMUST00000338667.1 ENSMUSG00000136992 (from geneSymbol) uc336qbo.1 uc336qbo.1 
ENSMUST00000338668.1 ENSMUSG00000136993 ENSMUST00000338668.1 ENSMUSG00000136993 (from geneSymbol) uc336qbp.1 uc336qbp.1 
ENSMUST00000338673.1 ENSMUSG00000136994 ENSMUST00000338673.1 ENSMUSG00000136994 (from geneSymbol) uc336qbu.1 uc336qbu.1 
ENSMUST00000338676.1 Gm57116 ENSMUST00000338676.1 Gm57116 (from geneSymbol) uc336qbx.1 uc336qbx.1 
ENSMUST00000338682.1 ENSMUSG00000136995 ENSMUST00000338682.1 ENSMUSG00000136995 (from geneSymbol) uc336qcd.1 uc336qcd.1 
ENSMUST00000338685.1 ENSMUSG00000136997 ENSMUST00000338685.1 ENSMUSG00000136997 (from geneSymbol) uc336qcf.1 uc336qcf.1 
ENSMUST00000338686.1 5430427M07Rik ENSMUST00000338686.1 5430427M07Rik (from geneSymbol) AK017349 uc336qcg.1 uc336qcg.1 
ENSMUST00000338687.1 ENSMUSG00000136998 ENSMUST00000338687.1 ENSMUSG00000136998 (from geneSymbol) uc336qch.1 uc336qch.1 
ENSMUST00000338690.1 ENSMUSG00000137000 ENSMUST00000338690.1 ENSMUSG00000137000 (from geneSymbol) uc336qcj.1 uc336qcj.1 
ENSMUST00000338691.1 Gm36146 ENSMUST00000338691.1 Gm36146 (from geneSymbol) uc336qck.1 uc336qck.1 
ENSMUST00000338696.1 ENSMUSG00000137001 ENSMUST00000338696.1 ENSMUSG00000137001 (from geneSymbol) uc336qcp.1 uc336qcp.1 
ENSMUST00000338700.1 ENSMUSG00000137002 ENSMUST00000338700.1 ENSMUSG00000137002 (from geneSymbol) uc336qct.1 uc336qct.1 
ENSMUST00000338704.1 ENSMUSG00000137003 ENSMUST00000338704.1 ENSMUSG00000137003 (from geneSymbol) uc336qcw.1 uc336qcw.1 
ENSMUST00000338711.1 Gm35554 ENSMUST00000338711.1 Gm35554 (from geneSymbol) AK161402 uc336qdd.1 uc336qdd.1 
ENSMUST00000338725.1 ENSMUSG00000137004 ENSMUST00000338725.1 ENSMUSG00000137004 (from geneSymbol) uc336qdr.1 uc336qdr.1 
ENSMUST00000338726.1 ENSMUSG00000137005 ENSMUST00000338726.1 ENSMUSG00000137005 (from geneSymbol) uc336qds.1 uc336qds.1 
ENSMUST00000338727.1 2610307P16Rik ENSMUST00000338727.1 2610307P16Rik (from geneSymbol) BC025054 uc336qdt.1 uc336qdt.1 
ENSMUST00000338906.1 ENSMUSG00000137006 ENSMUST00000338906.1 ENSMUSG00000137006 (from geneSymbol) uc336qkm.1 uc336qkm.1 
ENSMUST00000338913.1 ENSMUSG00000137007 ENSMUST00000338913.1 ENSMUSG00000137007 (from geneSymbol) uc336qkt.1 uc336qkt.1 
ENSMUST00000338928.1 Gm31698 ENSMUST00000338928.1 Gm31698 (from geneSymbol) uc336qli.1 uc336qli.1 
ENSMUST00000338932.1 ENSMUSG00000137008 ENSMUST00000338932.1 ENSMUSG00000137008 (from geneSymbol) uc336qlm.1 uc336qlm.1 
ENSMUST00000338933.1 ENSMUSG00000137009 ENSMUST00000338933.1 ENSMUSG00000137009 (from geneSymbol) uc336qln.1 uc336qln.1 
ENSMUST00000338934.1 ENSMUSG00000137010 ENSMUST00000338934.1 ENSMUSG00000137010 (from geneSymbol) uc336qlo.1 uc336qlo.1 
ENSMUST00000338939.1 ENSMUSG00000137011 ENSMUST00000338939.1 ENSMUSG00000137011 (from geneSymbol) uc336qlt.1 uc336qlt.1 
ENSMUST00000338943.1 ENSMUSG00000137012 ENSMUST00000338943.1 ENSMUSG00000137012 (from geneSymbol) uc336qlx.1 uc336qlx.1 
ENSMUST00000338944.1 ENSMUSG00000137013 ENSMUST00000338944.1 ENSMUSG00000137013 (from geneSymbol) uc336qly.1 uc336qly.1 
ENSMUST00000338945.1 ENSMUSG00000137014 ENSMUST00000338945.1 ENSMUSG00000137014 (from geneSymbol) uc336qlz.1 uc336qlz.1 
ENSMUST00000338946.1 ENSMUSG00000137015 ENSMUST00000338946.1 ENSMUSG00000137015 (from geneSymbol) uc336qma.1 uc336qma.1 
ENSMUST00000338947.1 ENSMUSG00000137016 ENSMUST00000338947.1 ENSMUSG00000137016 (from geneSymbol) uc336qmb.1 uc336qmb.1 
ENSMUST00000338954.1 ENSMUSG00000137017 ENSMUST00000338954.1 ENSMUSG00000137017 (from geneSymbol) uc336qmi.1 uc336qmi.1 
ENSMUST00000338959.1 ENSMUSG00000137018 ENSMUST00000338959.1 ENSMUSG00000137018 (from geneSymbol) uc336qmn.1 uc336qmn.1 
ENSMUST00000338960.1 ENSMUSG00000137019 ENSMUST00000338960.1 ENSMUSG00000137019 (from geneSymbol) uc336qmo.1 uc336qmo.1 
ENSMUST00000338961.1 ENSMUSG00000137020 ENSMUST00000338961.1 ENSMUSG00000137020 (from geneSymbol) uc336qmp.1 uc336qmp.1 
ENSMUST00000338962.1 ENSMUSG00000137021 ENSMUST00000338962.1 ENSMUSG00000137021 (from geneSymbol) uc336qmq.1 uc336qmq.1 
ENSMUST00000338963.1 ENSMUSG00000137022 ENSMUST00000338963.1 ENSMUSG00000137022 (from geneSymbol) uc336qmr.1 uc336qmr.1 
ENSMUST00000338964.1 ENSMUSG00000137023 ENSMUST00000338964.1 ENSMUSG00000137023 (from geneSymbol) uc336qms.1 uc336qms.1 
ENSMUST00000338966.1 ENSMUSG00000137024 ENSMUST00000338966.1 ENSMUSG00000137024 (from geneSymbol) uc336qmu.1 uc336qmu.1 
ENSMUST00000338969.1 ENSMUSG00000137025 ENSMUST00000338969.1 ENSMUSG00000137025 (from geneSymbol) uc336qmx.1 uc336qmx.1 
ENSMUST00000338972.1 ENSMUSG00000137026 ENSMUST00000338972.1 ENSMUSG00000137026 (from geneSymbol) uc336qna.1 uc336qna.1 
ENSMUST00000338973.1 ENSMUSG00000137027 ENSMUST00000338973.1 ENSMUSG00000137027 (from geneSymbol) uc336qnb.1 uc336qnb.1 
ENSMUST00000338974.1 ENSMUSG00000137028 ENSMUST00000338974.1 ENSMUSG00000137028 (from geneSymbol) uc336qnc.1 uc336qnc.1 
ENSMUST00000338983.1 ENSMUSG00000137029 ENSMUST00000338983.1 ENSMUSG00000137029 (from geneSymbol) uc336qnl.1 uc336qnl.1 
ENSMUST00000339000.1 ENSMUSG00000137030 ENSMUST00000339000.1 ENSMUSG00000137030 (from geneSymbol) uc336qoc.1 uc336qoc.1 
ENSMUST00000339002.1 ENSMUSG00000137031 ENSMUST00000339002.1 ENSMUSG00000137031 (from geneSymbol) uc336qoe.1 uc336qoe.1 
ENSMUST00000339005.1 ENSMUSG00000137032 ENSMUST00000339005.1 ENSMUSG00000137032 (from geneSymbol) uc336qoh.1 uc336qoh.1 
ENSMUST00000339006.1 ENSMUSG00000137033 ENSMUST00000339006.1 ENSMUSG00000137033 (from geneSymbol) uc336qoi.1 uc336qoi.1 
ENSMUST00000339014.1 ENSMUSG00000137034 ENSMUST00000339014.1 ENSMUSG00000137034 (from geneSymbol) uc336qoq.1 uc336qoq.1 
ENSMUST00000339016.1 ENSMUSG00000137035 ENSMUST00000339016.1 ENSMUSG00000137035 (from geneSymbol) uc336qos.1 uc336qos.1 
ENSMUST00000339059.1 ENSMUSG00000137036 ENSMUST00000339059.1 ENSMUSG00000137036 (from geneSymbol) uc336qqj.1 uc336qqj.1 
ENSMUST00000339062.1 ENSMUSG00000137037 ENSMUST00000339062.1 ENSMUSG00000137037 (from geneSymbol) uc336qqm.1 uc336qqm.1 
ENSMUST00000339065.1 ENSMUSG00000137038 ENSMUST00000339065.1 ENSMUSG00000137038 (from geneSymbol) uc336qqp.1 uc336qqp.1 
ENSMUST00000339067.1 ENSMUSG00000137039 ENSMUST00000339067.1 ENSMUSG00000137039 (from geneSymbol) uc336qqr.1 uc336qqr.1 
ENSMUST00000339072.1 ENSMUSG00000137040 ENSMUST00000339072.1 ENSMUSG00000137040 (from geneSymbol) uc336qqw.1 uc336qqw.1 
ENSMUST00000339074.1 ENSMUSG00000137041 ENSMUST00000339074.1 ENSMUSG00000137041 (from geneSymbol) uc336qqy.1 uc336qqy.1 
ENSMUST00000339078.1 ENSMUSG00000137042 ENSMUST00000339078.1 ENSMUSG00000137042 (from geneSymbol) uc336qrc.1 uc336qrc.1 
ENSMUST00000339079.1 1700106O07Rik ENSMUST00000339079.1 1700106O07Rik (from geneSymbol) AK007131 uc336qrd.1 uc336qrd.1 
ENSMUST00000339083.1 ENSMUSG00000137043 ENSMUST00000339083.1 ENSMUSG00000137043 (from geneSymbol) uc336qrh.1 uc336qrh.1 
ENSMUST00000339093.1 1700072O05Rik ENSMUST00000339093.1 1700072O05Rik (from geneSymbol) AK006942 uc336qrr.1 uc336qrr.1 
ENSMUST00000339119.1 ENSMUSG00000137044 ENSMUST00000339119.1 ENSMUSG00000137044 (from geneSymbol) uc336qsr.1 uc336qsr.1 
ENSMUST00000339138.1 Gm34586 ENSMUST00000339138.1 Gm34586 (from geneSymbol) uc336qtj.1 uc336qtj.1 
ENSMUST00000339175.1 ENSMUSG00000137045 ENSMUST00000339175.1 ENSMUSG00000137045 (from geneSymbol) uc336quu.1 uc336quu.1 
ENSMUST00000339176.1 ENSMUSG00000137046 ENSMUST00000339176.1 ENSMUSG00000137046 (from geneSymbol) uc336quv.1 uc336quv.1 
ENSMUST00000339177.1 ENSMUSG00000137047 ENSMUST00000339177.1 ENSMUSG00000137047 (from geneSymbol) uc336quw.1 uc336quw.1 
ENSMUST00000339184.1 ENSMUSG00000137048 ENSMUST00000339184.1 ENSMUSG00000137048 (from geneSymbol) uc336qvd.1 uc336qvd.1 
ENSMUST00000339185.1 ENSMUSG00000137049 ENSMUST00000339185.1 ENSMUSG00000137049 (from geneSymbol) uc336qve.1 uc336qve.1 
ENSMUST00000339186.1 ENSMUSG00000137050 ENSMUST00000339186.1 ENSMUSG00000137050 (from geneSymbol) DQ694443 uc336qvf.1 uc336qvf.1 
ENSMUST00000339187.1 ENSMUSG00000137051 ENSMUST00000339187.1 ENSMUSG00000137051 (from geneSymbol) uc336qvg.1 uc336qvg.1 
ENSMUST00000339188.1 ENSMUSG00000137052 ENSMUST00000339188.1 ENSMUSG00000137052 (from geneSymbol) uc336qvh.1 uc336qvh.1 
ENSMUST00000339189.1 ENSMUSG00000137053 ENSMUST00000339189.1 ENSMUSG00000137053 (from geneSymbol) uc336qvi.1 uc336qvi.1 
ENSMUST00000339192.1 ENSMUSG00000137054 ENSMUST00000339192.1 ENSMUSG00000137054 (from geneSymbol) uc336qvl.1 uc336qvl.1 
ENSMUST00000339195.1 ENSMUSG00000137055 ENSMUST00000339195.1 ENSMUSG00000137055 (from geneSymbol) uc336qvo.1 uc336qvo.1 
ENSMUST00000339197.1 ENSMUSG00000137056 ENSMUST00000339197.1 ENSMUSG00000137056 (from geneSymbol) uc336qvq.1 uc336qvq.1 
ENSMUST00000339202.1 Etos1 ENSMUST00000339202.1 Etos1 (from geneSymbol) uc336qvv.1 uc336qvv.1 
ENSMUST00000339203.1 ENSMUSG00000137057 ENSMUST00000339203.1 ENSMUSG00000137057 (from geneSymbol) uc336qvw.1 uc336qvw.1 
ENSMUST00000339205.1 Gm42654 ENSMUST00000339205.1 Gm42654 (from geneSymbol) AK076949 uc336qvy.1 uc336qvy.1 
ENSMUST00000339255.1 ENSMUSG00000137058 ENSMUST00000339255.1 ENSMUSG00000137058 (from geneSymbol) uc336qxw.1 uc336qxw.1 
ENSMUST00000339259.1 ENSMUSG00000137059 ENSMUST00000339259.1 ENSMUSG00000137059 (from geneSymbol) uc336qya.1 uc336qya.1 
ENSMUST00000339263.1 ENSMUSG00000137060 ENSMUST00000339263.1 ENSMUSG00000137060 (from geneSymbol) uc336qye.1 uc336qye.1 
ENSMUST00000339264.1 ENSMUSG00000137061 ENSMUST00000339264.1 ENSMUSG00000137061 (from geneSymbol) uc336qyf.1 uc336qyf.1 
ENSMUST00000339265.1 ENSMUSG00000137062 ENSMUST00000339265.1 ENSMUSG00000137062 (from geneSymbol) uc336qyg.1 uc336qyg.1 
ENSMUST00000339282.1 ENSMUSG00000137063 ENSMUST00000339282.1 ENSMUSG00000137063 (from geneSymbol) uc336qyx.1 uc336qyx.1 
ENSMUST00000339288.1 ENSMUSG00000137064 ENSMUST00000339288.1 ENSMUSG00000137064 (from geneSymbol) uc336qzd.1 uc336qzd.1 
ENSMUST00000339292.1 ENSMUSG00000137065 ENSMUST00000339292.1 ENSMUSG00000137065 (from geneSymbol) uc336qzh.1 uc336qzh.1 
ENSMUST00000339298.1 ENSMUSG00000137066 ENSMUST00000339298.1 ENSMUSG00000137066 (from geneSymbol) uc336qzn.1 uc336qzn.1 
ENSMUST00000339301.1 ENSMUSG00000137067 ENSMUST00000339301.1 ENSMUSG00000137067 (from geneSymbol) uc336qzq.1 uc336qzq.1 
ENSMUST00000339303.1 ENSMUSG00000137069 ENSMUST00000339303.1 ENSMUSG00000137069 (from geneSymbol) uc336qzr.1 uc336qzr.1 
ENSMUST00000339304.1 ENSMUSG00000137070 ENSMUST00000339304.1 ENSMUSG00000137070 (from geneSymbol) uc336qzs.1 uc336qzs.1 
ENSMUST00000339305.1 ENSMUSG00000137071 ENSMUST00000339305.1 ENSMUSG00000137071 (from geneSymbol) uc336qzt.1 uc336qzt.1 
ENSMUST00000339309.1 ENSMUSG00000137072 ENSMUST00000339309.1 ENSMUSG00000137072 (from geneSymbol) uc336qzx.1 uc336qzx.1 
ENSMUST00000339316.1 ENSMUSG00000137073 ENSMUST00000339316.1 ENSMUSG00000137073 (from geneSymbol) uc336rae.1 uc336rae.1 
ENSMUST00000339317.1 Gm17055 ENSMUST00000339317.1 Gm17055 (from geneSymbol) uc336raf.1 uc336raf.1 
ENSMUST00000339321.1 ENSMUSG00000137074 ENSMUST00000339321.1 ENSMUSG00000137074 (from geneSymbol) uc336raj.1 uc336raj.1 
ENSMUST00000339323.1 ENSMUSG00000137075 ENSMUST00000339323.1 ENSMUSG00000137075 (from geneSymbol) uc336ral.1 uc336ral.1 
ENSMUST00000339326.1 ENSMUSG00000137076 ENSMUST00000339326.1 ENSMUSG00000137076 (from geneSymbol) uc336rao.1 uc336rao.1 
ENSMUST00000339327.1 Gm36198 ENSMUST00000339327.1 Gm36198 (from geneSymbol) uc336rap.1 uc336rap.1 
ENSMUST00000339332.1 Gm15169 ENSMUST00000339332.1 Gm15169 (from geneSymbol) AK163197 uc336rau.1 uc336rau.1 
ENSMUST00000339482.1 ENSMUSG00000137077 ENSMUST00000339482.1 ENSMUSG00000137077 (from geneSymbol) uc336rgm.1 uc336rgm.1 
ENSMUST00000339484.1 ENSMUSG00000137078 ENSMUST00000339484.1 ENSMUSG00000137078 (from geneSymbol) uc336rgo.1 uc336rgo.1 
ENSMUST00000339490.1 Grip1os1 ENSMUST00000339490.1 Grip1os1 (from geneSymbol) AK019561 uc336rgu.1 uc336rgu.1 
ENSMUST00000339498.1 ENSMUSG00000137079 ENSMUST00000339498.1 ENSMUSG00000137079 (from geneSymbol) uc336rhc.1 uc336rhc.1 
ENSMUST00000339499.1 ENSMUSG00000137080 ENSMUST00000339499.1 ENSMUSG00000137080 (from geneSymbol) uc336rhd.1 uc336rhd.1 
ENSMUST00000339500.1 ENSMUSG00000137081 ENSMUST00000339500.1 ENSMUSG00000137081 (from geneSymbol) uc336rhe.1 uc336rhe.1 
ENSMUST00000339501.1 ENSMUSG00000137082 ENSMUST00000339501.1 ENSMUSG00000137082 (from geneSymbol) uc336rhf.1 uc336rhf.1 
ENSMUST00000339509.1 Gm5627 ENSMUST00000339509.1 Gm5627 (from geneSymbol) AK041874 uc336rhn.1 uc336rhn.1 
ENSMUST00000339526.1 ENSMUSG00000137083 ENSMUST00000339526.1 ENSMUSG00000137083 (from geneSymbol) uc336rie.1 uc336rie.1 
ENSMUST00000339533.1 C730002L08Rik ENSMUST00000339533.1 C730002L08Rik (from geneSymbol) AK050017 uc336ril.1 uc336ril.1 
ENSMUST00000339557.1 ENSMUSG00000121416 ENSMUST00000339557.1 ENSMUSG00000121416 (from geneSymbol) AK006470 uc336rji.1 uc336rji.1 
ENSMUST00000339575.1 ENSMUSG00000137084 ENSMUST00000339575.1 ENSMUSG00000137084 (from geneSymbol) uc336rka.1 uc336rka.1 
ENSMUST00000339579.1 ENSMUSG00000137085 ENSMUST00000339579.1 ENSMUSG00000137085 (from geneSymbol) uc336rke.1 uc336rke.1 
ENSMUST00000339582.1 ENSMUSG00000137086 ENSMUST00000339582.1 ENSMUSG00000137086 (from geneSymbol) uc336rkh.1 uc336rkh.1 
ENSMUST00000339583.1 ENSMUSG00000137087 ENSMUST00000339583.1 ENSMUSG00000137087 (from geneSymbol) uc336rki.1 uc336rki.1 
ENSMUST00000339584.1 ENSMUSG00000137088 ENSMUST00000339584.1 ENSMUSG00000137088 (from geneSymbol) uc336rkj.1 uc336rkj.1 
ENSMUST00000339586.1 ENSMUSG00000137089 ENSMUST00000339586.1 ENSMUSG00000137089 (from geneSymbol) uc336rkl.1 uc336rkl.1 
ENSMUST00000339587.1 ENSMUSG00000137090 ENSMUST00000339587.1 ENSMUSG00000137090 (from geneSymbol) uc336rkm.1 uc336rkm.1 
ENSMUST00000339594.1 ENSMUSG00000137091 ENSMUST00000339594.1 ENSMUSG00000137091 (from geneSymbol) uc336rkt.1 uc336rkt.1 
ENSMUST00000339596.1 ENSMUSG00000137092 ENSMUST00000339596.1 ENSMUSG00000137092 (from geneSymbol) uc336rkv.1 uc336rkv.1 
ENSMUST00000339602.1 2010010A06Rik ENSMUST00000339602.1 2010010A06Rik (from geneSymbol) AK008172 uc336rlb.1 uc336rlb.1 
ENSMUST00000339613.1 ENSMUSG00000137093 ENSMUST00000339613.1 ENSMUSG00000137093 (from geneSymbol) uc336rlm.1 uc336rlm.1 
ENSMUST00000339614.1 ENSMUSG00000137094 ENSMUST00000339614.1 ENSMUSG00000137094 (from geneSymbol) uc336rln.1 uc336rln.1 
ENSMUST00000339615.1 ENSMUSG00000137095 ENSMUST00000339615.1 ENSMUSG00000137095 (from geneSymbol) uc336rlo.1 uc336rlo.1 
ENSMUST00000339617.1 ENSMUSG00000137096 ENSMUST00000339617.1 ENSMUSG00000137096 (from geneSymbol) AK006494 uc336rlq.1 uc336rlq.1 
ENSMUST00000339618.1 ENSMUSG00000137097 ENSMUST00000339618.1 ENSMUSG00000137097 (from geneSymbol) uc336rlr.1 uc336rlr.1 
ENSMUST00000339620.1 ENSMUSG00000137098 ENSMUST00000339620.1 ENSMUSG00000137098 (from geneSymbol) AK020930 uc336rlt.1 uc336rlt.1 
ENSMUST00000339649.1 ENSMUSG00000137099 ENSMUST00000339649.1 ENSMUSG00000137099 (from geneSymbol) uc336rmw.1 uc336rmw.1 
ENSMUST00000339650.1 ENSMUSG00000137100 ENSMUST00000339650.1 ENSMUSG00000137100 (from geneSymbol) uc336rmx.1 uc336rmx.1 
ENSMUST00000339652.1 ENSMUSG00000137101 ENSMUST00000339652.1 ENSMUSG00000137101 (from geneSymbol) uc336rmz.1 uc336rmz.1 
ENSMUST00000339653.1 ENSMUSG00000137102 ENSMUST00000339653.1 ENSMUSG00000137102 (from geneSymbol) uc336rna.1 uc336rna.1 
ENSMUST00000339654.1 ENSMUSG00000137103 ENSMUST00000339654.1 ENSMUSG00000137103 (from geneSymbol) uc336rnb.1 uc336rnb.1 
ENSMUST00000339656.1 ENSMUSG00000137104 ENSMUST00000339656.1 ENSMUSG00000137104 (from geneSymbol) uc336rnd.1 uc336rnd.1 
ENSMUST00000339658.1 ENSMUSG00000137105 ENSMUST00000339658.1 ENSMUSG00000137105 (from geneSymbol) uc336rnf.1 uc336rnf.1 
ENSMUST00000339661.1 ENSMUSG00000137106 ENSMUST00000339661.1 ENSMUSG00000137106 (from geneSymbol) FJ541087 uc336rni.1 uc336rni.1 
ENSMUST00000339666.1 ENSMUSG00000137107 ENSMUST00000339666.1 ENSMUSG00000137107 (from geneSymbol) uc336rnn.1 uc336rnn.1 
ENSMUST00000339692.1 ENSMUSG00000137108 ENSMUST00000339692.1 ENSMUSG00000137108 (from geneSymbol) uc336ron.1 uc336ron.1 
ENSMUST00000339700.1 A930001A20Rik ENSMUST00000339700.1 A930001A20Rik (from geneSymbol) AK044583 uc336rov.1 uc336rov.1 
ENSMUST00000339713.1 ENSMUSG00000137109 ENSMUST00000339713.1 ENSMUSG00000137109 (from geneSymbol) uc336rpi.1 uc336rpi.1 
ENSMUST00000339715.1 ENSMUSG00000137110 ENSMUST00000339715.1 ENSMUSG00000137110 (from geneSymbol) uc336rpk.1 uc336rpk.1 
ENSMUST00000339716.1 ENSMUSG00000137111 ENSMUST00000339716.1 ENSMUSG00000137111 (from geneSymbol) uc336rpl.1 uc336rpl.1 
ENSMUST00000339717.1 Gm28364 ENSMUST00000339717.1 Gm28364 (from geneSymbol) uc336rpm.1 uc336rpm.1 
ENSMUST00000339724.1 ENSMUSG00000137112 ENSMUST00000339724.1 ENSMUSG00000137112 (from geneSymbol) uc336rpt.1 uc336rpt.1 
ENSMUST00000339732.1 ENSMUSG00000137113 ENSMUST00000339732.1 ENSMUSG00000137113 (from geneSymbol) uc336rqb.1 uc336rqb.1 
ENSMUST00000339735.1 Kif16bos ENSMUST00000339735.1 Kif16bos (from geneSymbol) AK015749 uc336rqe.1 uc336rqe.1 
ENSMUST00000339810.1 ENSMUSG00000137114 ENSMUST00000339810.1 ENSMUSG00000137114 (from geneSymbol) uc336rtb.1 uc336rtb.1 
ENSMUST00000339811.1 ENSMUSG00000137115 ENSMUST00000339811.1 ENSMUSG00000137115 (from geneSymbol) uc336rtc.1 uc336rtc.1 
ENSMUST00000339813.1 ENSMUSG00000137116 ENSMUST00000339813.1 ENSMUSG00000137116 (from geneSymbol) uc336rte.1 uc336rte.1 
ENSMUST00000339826.1 4930563I02Rik ENSMUST00000339826.1 4930563I02Rik (from geneSymbol) AK015998 uc336rtr.1 uc336rtr.1 
ENSMUST00000339848.1 ENSMUSG00000137117 ENSMUST00000339848.1 ENSMUSG00000137117 (from geneSymbol) uc336run.1 uc336run.1 
ENSMUST00000339849.1 ENSMUSG00000137118 ENSMUST00000339849.1 ENSMUSG00000137118 (from geneSymbol) uc336ruo.1 uc336ruo.1 
ENSMUST00000339850.1 ENSMUSG00000137119 ENSMUST00000339850.1 ENSMUSG00000137119 (from geneSymbol) uc336rup.1 uc336rup.1 
ENSMUST00000339852.1 ENSMUSG00000137120 ENSMUST00000339852.1 ENSMUSG00000137120 (from geneSymbol) uc336rur.1 uc336rur.1 
ENSMUST00000339859.1 ENSMUSG00000137121 ENSMUST00000339859.1 ENSMUSG00000137121 (from geneSymbol) X62896 uc336ruy.1 uc336ruy.1 
ENSMUST00000339860.1 ENSMUSG00000137122 ENSMUST00000339860.1 ENSMUSG00000137122 (from geneSymbol) uc336ruz.1 uc336ruz.1 
ENSMUST00000339862.1 Gm57206 ENSMUST00000339862.1 Gm57206 (from geneSymbol) AK172128 uc336rvb.1 uc336rvb.1 
ENSMUST00000339872.1 ENSMUSG00000137123 ENSMUST00000339872.1 ENSMUSG00000137123 (from geneSymbol) uc336rvl.1 uc336rvl.1 
ENSMUST00000339874.1 ENSMUSG00000137124 ENSMUST00000339874.1 ENSMUSG00000137124 (from geneSymbol) uc336rvn.1 uc336rvn.1 
ENSMUST00000339881.1 ENSMUSG00000137125 ENSMUST00000339881.1 ENSMUSG00000137125 (from geneSymbol) uc336rvu.1 uc336rvu.1 
ENSMUST00000339885.1 ENSMUSG00000137126 ENSMUST00000339885.1 ENSMUSG00000137126 (from geneSymbol) uc336rvy.1 uc336rvy.1 
ENSMUST00000339886.1 ENSMUSG00000137127 ENSMUST00000339886.1 ENSMUSG00000137127 (from geneSymbol) AK015892 uc336rvz.1 uc336rvz.1 
ENSMUST00000339908.1 Lhx1os ENSMUST00000339908.1 Lhx1os (from geneSymbol) AK018772 uc336rwv.1 uc336rwv.1 
ENSMUST00000339982.1 ENSMUSG00000137128 ENSMUST00000339982.1 ENSMUSG00000137128 (from geneSymbol) uc336rzr.1 uc336rzr.1 
ENSMUST00000339985.1 ENSMUSG00000137129 ENSMUST00000339985.1 ENSMUSG00000137129 (from geneSymbol) uc336rzu.1 uc336rzu.1 
ENSMUST00000339991.1 ENSMUSG00000137130 ENSMUST00000339991.1 ENSMUSG00000137130 (from geneSymbol) uc336saa.1 uc336saa.1 
ENSMUST00000339994.1 ENSMUSG00000137131 ENSMUST00000339994.1 ENSMUSG00000137131 (from geneSymbol) LF201707 uc336sad.1 uc336sad.1 
ENSMUST00000339999.1 ENSMUSG00000137132 ENSMUST00000339999.1 ENSMUSG00000137132 (from geneSymbol) uc336sai.1 uc336sai.1 
ENSMUST00000340000.1 ENSMUSG00000137133 ENSMUST00000340000.1 ENSMUSG00000137133 (from geneSymbol) uc336saj.1 uc336saj.1 
ENSMUST00000340001.1 ENSMUSG00000137134 ENSMUST00000340001.1 ENSMUSG00000137134 (from geneSymbol) uc336sak.1 uc336sak.1 
ENSMUST00000340002.1 ENSMUSG00000137135 ENSMUST00000340002.1 ENSMUSG00000137135 (from geneSymbol) uc336sal.1 uc336sal.1 
ENSMUST00000340003.1 ENSMUSG00000137136 ENSMUST00000340003.1 ENSMUSG00000137136 (from geneSymbol) uc336sam.1 uc336sam.1 
ENSMUST00000340008.1 ENSMUSG00000137137 ENSMUST00000340008.1 ENSMUSG00000137137 (from geneSymbol) AK050336 uc336sar.1 uc336sar.1 
ENSMUST00000340019.1 ENSMUSG00000137138 ENSMUST00000340019.1 ENSMUSG00000137138 (from geneSymbol) uc336sbc.1 uc336sbc.1 
ENSMUST00000340025.1 ENSMUSG00000137139 ENSMUST00000340025.1 ENSMUSG00000137139 (from geneSymbol) uc336sbi.1 uc336sbi.1 
ENSMUST00000340028.1 ENSMUSG00000137140 ENSMUST00000340028.1 ENSMUSG00000137140 (from geneSymbol) uc336sbl.1 uc336sbl.1 
ENSMUST00000340029.1 ENSMUSG00000137141 ENSMUST00000340029.1 ENSMUSG00000137141 (from geneSymbol) uc336sbm.1 uc336sbm.1 
ENSMUST00000340034.1 Gm39164 ENSMUST00000340034.1 Gm39164 (from geneSymbol) AK076961 uc336sbr.1 uc336sbr.1 
ENSMUST00000340041.1 ENSMUSG00000137142 ENSMUST00000340041.1 ENSMUSG00000137142 (from geneSymbol) uc336sby.1 uc336sby.1 
ENSMUST00000340042.1 ENSMUSG00000137143 ENSMUST00000340042.1 ENSMUSG00000137143 (from geneSymbol) uc336sbz.1 uc336sbz.1 
ENSMUST00000340043.1 ENSMUSG00000137144 ENSMUST00000340043.1 ENSMUSG00000137144 (from geneSymbol) uc336sca.1 uc336sca.1 
ENSMUST00000340044.1 ENSMUSG00000137145 ENSMUST00000340044.1 ENSMUSG00000137145 (from geneSymbol) uc336scb.1 uc336scb.1 
ENSMUST00000340045.1 ENSMUSG00000137146 ENSMUST00000340045.1 ENSMUSG00000137146 (from geneSymbol) uc336scc.1 uc336scc.1 
ENSMUST00000340046.1 ENSMUSG00000137147 ENSMUST00000340046.1 ENSMUSG00000137147 (from geneSymbol) uc336scd.1 uc336scd.1 
ENSMUST00000340048.1 ENSMUSG00000137148 ENSMUST00000340048.1 ENSMUSG00000137148 (from geneSymbol) uc336scf.1 uc336scf.1 
ENSMUST00000340051.1 ENSMUSG00000137149 ENSMUST00000340051.1 ENSMUSG00000137149 (from geneSymbol) uc336sci.1 uc336sci.1 
ENSMUST00000340069.1 ENSMUSG00000137150 ENSMUST00000340069.1 ENSMUSG00000137150 (from geneSymbol) uc336sda.1 uc336sda.1 
ENSMUST00000340070.1 ENSMUSG00000137151 ENSMUST00000340070.1 ENSMUSG00000137151 (from geneSymbol) uc336sdb.1 uc336sdb.1 
ENSMUST00000340071.1 ENSMUSG00000137152 ENSMUST00000340071.1 ENSMUSG00000137152 (from geneSymbol) uc336sdc.1 uc336sdc.1 
ENSMUST00000340073.1 ENSMUSG00000137153 ENSMUST00000340073.1 ENSMUSG00000137153 (from geneSymbol) uc336sde.1 uc336sde.1 
ENSMUST00000340074.1 ENSMUSG00000137154 ENSMUST00000340074.1 ENSMUSG00000137154 (from geneSymbol) uc336sdf.1 uc336sdf.1 
ENSMUST00000340076.1 ENSMUSG00000137155 ENSMUST00000340076.1 ENSMUSG00000137155 (from geneSymbol) uc336sdh.1 uc336sdh.1 
ENSMUST00000340094.1 Gm26891 ENSMUST00000340094.1 Gm26891 (from geneSymbol) AK076358 uc336sdz.1 uc336sdz.1 
ENSMUST00000340101.1 ENSMUSG00000137156 ENSMUST00000340101.1 ENSMUSG00000137156 (from geneSymbol) uc336seg.1 uc336seg.1 
ENSMUST00000340103.1 ENSMUSG00000137158 ENSMUST00000340103.1 ENSMUSG00000137158 (from geneSymbol) uc336seh.1 uc336seh.1 
ENSMUST00000340105.1 ENSMUSG00000137159 ENSMUST00000340105.1 ENSMUSG00000137159 (from geneSymbol) uc336sej.1 uc336sej.1 
ENSMUST00000340106.1 ENSMUSG00000137160 ENSMUST00000340106.1 ENSMUSG00000137160 (from geneSymbol) uc336sek.1 uc336sek.1 
ENSMUST00000340108.1 ENSMUSG00000137161 ENSMUST00000340108.1 ENSMUSG00000137161 (from geneSymbol) uc336sem.1 uc336sem.1 
ENSMUST00000340113.1 ENSMUSG00000137162 ENSMUST00000340113.1 ENSMUSG00000137162 (from geneSymbol) uc336ser.1 uc336ser.1 
ENSMUST00000340114.1 ENSMUSG00000137163 ENSMUST00000340114.1 ENSMUSG00000137163 (from geneSymbol) uc336ses.1 uc336ses.1 
ENSMUST00000340115.1 ENSMUSG00000137164 ENSMUST00000340115.1 ENSMUSG00000137164 (from geneSymbol) uc336set.1 uc336set.1 
ENSMUST00000340121.1 ENSMUSG00000137165 ENSMUST00000340121.1 ENSMUSG00000137165 (from geneSymbol) uc336sey.1 uc336sey.1 
ENSMUST00000340141.1 Gm57379 ENSMUST00000340141.1 Gm57379 (from geneSymbol) uc336sfs.1 uc336sfs.1 
ENSMUST00000340152.1 4930520O04Rik ENSMUST00000340152.1 4930520O04Rik (from geneSymbol) AK040958 uc336sgd.1 uc336sgd.1 
ENSMUST00000340175.1 ENSMUSG00000137166 ENSMUST00000340175.1 ENSMUSG00000137166 (from geneSymbol) uc336sha.1 uc336sha.1 
ENSMUST00000340178.1 4933416E14Rik ENSMUST00000340178.1 4933416E14Rik (from geneSymbol) uc336shd.1 uc336shd.1 
ENSMUST00000340199.1 ENSMUSG00000137168 ENSMUST00000340199.1 ENSMUSG00000137168 (from geneSymbol) uc336shy.1 uc336shy.1 
ENSMUST00000340217.1 Gm31205 ENSMUST00000340217.1 Gm31205 (from geneSymbol) uc336siq.1 uc336siq.1 
ENSMUST00000340228.1 ENSMUSG00000137169 ENSMUST00000340228.1 ENSMUSG00000137169 (from geneSymbol) uc336sjb.1 uc336sjb.1 
ENSMUST00000340230.1 ENSMUSG00000137170 ENSMUST00000340230.1 ENSMUSG00000137170 (from geneSymbol) uc336sjd.1 uc336sjd.1 
ENSMUST00000340231.1 ENSMUSG00000137171 ENSMUST00000340231.1 ENSMUSG00000137171 (from geneSymbol) uc336sje.1 uc336sje.1 
ENSMUST00000340234.1 ENSMUSG00000137172 ENSMUST00000340234.1 ENSMUSG00000137172 (from geneSymbol) uc336sjh.1 uc336sjh.1 
ENSMUST00000340235.1 ENSMUSG00000137173 ENSMUST00000340235.1 ENSMUSG00000137173 (from geneSymbol) uc336sji.1 uc336sji.1 
ENSMUST00000340236.1 ENSMUSG00000137174 ENSMUST00000340236.1 ENSMUSG00000137174 (from geneSymbol) uc336sjj.1 uc336sjj.1 
ENSMUST00000340239.1 ENSMUSG00000137175 ENSMUST00000340239.1 ENSMUSG00000137175 (from geneSymbol) uc336sjm.1 uc336sjm.1 
ENSMUST00000340242.1 ENSMUSG00000137176 ENSMUST00000340242.1 ENSMUSG00000137176 (from geneSymbol) uc336sjp.1 uc336sjp.1 
ENSMUST00000340243.1 ENSMUSG00000137177 ENSMUST00000340243.1 ENSMUSG00000137177 (from geneSymbol) uc336sjq.1 uc336sjq.1 
ENSMUST00000340244.1 ENSMUSG00000137178 ENSMUST00000340244.1 ENSMUSG00000137178 (from geneSymbol) uc336sjr.1 uc336sjr.1 
ENSMUST00000340245.1 ENSMUSG00000137179 ENSMUST00000340245.1 ENSMUSG00000137179 (from geneSymbol) uc336sjs.1 uc336sjs.1 
ENSMUST00000340246.1 ENSMUSG00000137180 ENSMUST00000340246.1 ENSMUSG00000137180 (from geneSymbol) uc336sjt.1 uc336sjt.1 
ENSMUST00000340248.1 ENSMUSG00000137181 ENSMUST00000340248.1 ENSMUSG00000137181 (from geneSymbol) uc336sjv.1 uc336sjv.1 
ENSMUST00000340254.1 ENSMUSG00000137182 ENSMUST00000340254.1 ENSMUSG00000137182 (from geneSymbol) uc336skb.1 uc336skb.1 
ENSMUST00000340256.1 ENSMUSG00000137183 ENSMUST00000340256.1 ENSMUSG00000137183 (from geneSymbol) uc336skd.1 uc336skd.1 
ENSMUST00000340263.1 Gm38414 ENSMUST00000340263.1 Gm38414 (from geneSymbol) AK082764 uc336skk.1 uc336skk.1 
ENSMUST00000340276.1 ENSMUSG00000137184 ENSMUST00000340276.1 ENSMUSG00000137184 (from geneSymbol) uc336skx.1 uc336skx.1 
ENSMUST00000340277.1 ENSMUSG00000137185 ENSMUST00000340277.1 ENSMUSG00000137185 (from geneSymbol) uc336sky.1 uc336sky.1 
ENSMUST00000340278.1 ENSMUSG00000137186 ENSMUST00000340278.1 ENSMUSG00000137186 (from geneSymbol) uc336skz.1 uc336skz.1 
ENSMUST00000340279.1 ENSMUSG00000137187 ENSMUST00000340279.1 ENSMUSG00000137187 (from geneSymbol) uc336sla.1 uc336sla.1 
ENSMUST00000340280.1 ENSMUSG00000137188 ENSMUST00000340280.1 ENSMUSG00000137188 (from geneSymbol) uc336slb.1 uc336slb.1 
ENSMUST00000340281.1 ENSMUSG00000137189 ENSMUST00000340281.1 ENSMUSG00000137189 (from geneSymbol) uc336slc.1 uc336slc.1 
ENSMUST00000340283.1 ENSMUSG00000137190 ENSMUST00000340283.1 ENSMUSG00000137190 (from geneSymbol) uc336sle.1 uc336sle.1 
ENSMUST00000340285.1 ENSMUSG00000137191 ENSMUST00000340285.1 ENSMUSG00000137191 (from geneSymbol) uc336slg.1 uc336slg.1 
ENSMUST00000340287.1 ENSMUSG00000137192 ENSMUST00000340287.1 ENSMUSG00000137192 (from geneSymbol) uc336sli.1 uc336sli.1 
ENSMUST00000340288.1 ENSMUSG00000137193 ENSMUST00000340288.1 ENSMUSG00000137193 (from geneSymbol) uc336slj.1 uc336slj.1 
ENSMUST00000340291.1 ENSMUSG00000137194 ENSMUST00000340291.1 ENSMUSG00000137194 (from geneSymbol) uc336slm.1 uc336slm.1 
ENSMUST00000340324.1 ENSMUSG00000137195 ENSMUST00000340324.1 ENSMUSG00000137195 (from geneSymbol) uc336smt.1 uc336smt.1 
ENSMUST00000340325.1 ENSMUSG00000137196 ENSMUST00000340325.1 ENSMUSG00000137196 (from geneSymbol) uc336smu.1 uc336smu.1 
ENSMUST00000340326.1 ENSMUSG00000137197 ENSMUST00000340326.1 ENSMUSG00000137197 (from geneSymbol) uc336smv.1 uc336smv.1 
ENSMUST00000340327.1 ENSMUSG00000137198 ENSMUST00000340327.1 ENSMUSG00000137198 (from geneSymbol) uc336smw.1 uc336smw.1 
ENSMUST00000340330.1 ENSMUSG00000137199 ENSMUST00000340330.1 ENSMUSG00000137199 (from geneSymbol) DQ721237 uc336smz.1 uc336smz.1 
ENSMUST00000340331.1 ENSMUSG00000137200 ENSMUST00000340331.1 ENSMUSG00000137200 (from geneSymbol) uc336sna.1 uc336sna.1 
ENSMUST00000340332.1 ENSMUSG00000137201 ENSMUST00000340332.1 ENSMUSG00000137201 (from geneSymbol) uc336snb.1 uc336snb.1 
ENSMUST00000340340.1 ENSMUSG00000137202 ENSMUST00000340340.1 ENSMUSG00000137202 (from geneSymbol) uc336snj.1 uc336snj.1 
ENSMUST00000340348.1 ENSMUSG00000137203 ENSMUST00000340348.1 ENSMUSG00000137203 (from geneSymbol) uc336snr.1 uc336snr.1 
ENSMUST00000340353.1 ENSMUSG00000137204 ENSMUST00000340353.1 ENSMUSG00000137204 (from geneSymbol) uc336snw.1 uc336snw.1 
ENSMUST00000340354.1 ENSMUSG00000137205 ENSMUST00000340354.1 ENSMUSG00000137205 (from geneSymbol) uc336snx.1 uc336snx.1 
ENSMUST00000340357.1 ENSMUSG00000137206 ENSMUST00000340357.1 ENSMUSG00000137206 (from geneSymbol) uc336soa.1 uc336soa.1 
ENSMUST00000340360.1 ENSMUSG00000137207 ENSMUST00000340360.1 ENSMUSG00000137207 (from geneSymbol) uc336sod.1 uc336sod.1 
ENSMUST00000340361.1 Gm57406 ENSMUST00000340361.1 Gm57406 (from geneSymbol) uc336soe.1 uc336soe.1 
ENSMUST00000340393.1 ENSMUSG00000137208 ENSMUST00000340393.1 ENSMUSG00000137208 (from geneSymbol) uc336spk.1 uc336spk.1 
ENSMUST00000340395.1 Gm26994 ENSMUST00000340395.1 Gm26994 (from geneSymbol) AK082412 uc336spm.1 uc336spm.1 
ENSMUST00000340399.1 ENSMUSG00000137209 ENSMUST00000340399.1 ENSMUSG00000137209 (from geneSymbol) KY468049 uc336spq.1 uc336spq.1 
ENSMUST00000340405.1 ENSMUSG00000137210 ENSMUST00000340405.1 ENSMUSG00000137210 (from geneSymbol) uc336spw.1 uc336spw.1 
ENSMUST00000340408.1 Gm42745 ENSMUST00000340408.1 Gm42745 (from geneSymbol) uc336spz.1 uc336spz.1 
ENSMUST00000340411.1 Gm33373 ENSMUST00000340411.1 Gm33373 (from geneSymbol) uc336sqc.1 uc336sqc.1 
ENSMUST00000340415.1 ENSMUSG00000137211 ENSMUST00000340415.1 ENSMUSG00000137211 (from geneSymbol) uc336sqg.1 uc336sqg.1 
ENSMUST00000340418.1 ENSMUSG00000137212 ENSMUST00000340418.1 ENSMUSG00000137212 (from geneSymbol) AK076931 uc336sqj.1 uc336sqj.1 
ENSMUST00000340424.1 ENSMUSG00000137213 ENSMUST00000340424.1 ENSMUSG00000137213 (from geneSymbol) uc336sqp.1 uc336sqp.1 
ENSMUST00000340425.1 ENSMUSG00000137214 ENSMUST00000340425.1 ENSMUSG00000137214 (from geneSymbol) uc336sqq.1 uc336sqq.1 
ENSMUST00000340452.1 ENSMUSG00000137215 ENSMUST00000340452.1 ENSMUSG00000137215 (from geneSymbol) uc336srr.1 uc336srr.1 
ENSMUST00000340454.1 ENSMUSG00000137216 ENSMUST00000340454.1 ENSMUSG00000137216 (from geneSymbol) uc336srt.1 uc336srt.1 
ENSMUST00000340458.1 ENSMUSG00000137217 ENSMUST00000340458.1 ENSMUSG00000137217 (from geneSymbol) uc336srx.1 uc336srx.1 
ENSMUST00000340473.1 ENSMUSG00000137218 ENSMUST00000340473.1 ENSMUSG00000137218 (from geneSymbol) uc336ssm.1 uc336ssm.1 
ENSMUST00000340474.1 ENSMUSG00000137219 ENSMUST00000340474.1 ENSMUSG00000137219 (from geneSymbol) uc336ssn.1 uc336ssn.1 
ENSMUST00000340475.1 ENSMUSG00000137220 ENSMUST00000340475.1 ENSMUSG00000137220 (from geneSymbol) uc336sso.1 uc336sso.1 
ENSMUST00000340476.1 Gm13562 ENSMUST00000340476.1 Gm13562 (from geneSymbol) uc336ssp.1 uc336ssp.1 
ENSMUST00000340477.1 ENSMUSG00000137221 ENSMUST00000340477.1 ENSMUSG00000137221 (from geneSymbol) uc336ssq.1 uc336ssq.1 
ENSMUST00000340478.1 ENSMUSG00000137222 ENSMUST00000340478.1 ENSMUSG00000137222 (from geneSymbol) uc336ssr.1 uc336ssr.1 
ENSMUST00000340482.1 ENSMUSG00000137223 ENSMUST00000340482.1 ENSMUSG00000137223 (from geneSymbol) AK043219 uc336ssv.1 uc336ssv.1 
ENSMUST00000340485.1 ENSMUSG00000137224 ENSMUST00000340485.1 ENSMUSG00000137224 (from geneSymbol) uc336ssy.1 uc336ssy.1 
ENSMUST00000340490.1 ENSMUSG00000137225 ENSMUST00000340490.1 ENSMUSG00000137225 (from geneSymbol) uc336std.1 uc336std.1 
ENSMUST00000340491.1 ENSMUSG00000137226 ENSMUST00000340491.1 ENSMUSG00000137226 (from geneSymbol) uc336ste.1 uc336ste.1 
ENSMUST00000340492.1 ENSMUSG00000137227 ENSMUST00000340492.1 ENSMUSG00000137227 (from geneSymbol) uc336stf.1 uc336stf.1 
ENSMUST00000340499.1 ENSMUSG00000137228 ENSMUST00000340499.1 ENSMUSG00000137228 (from geneSymbol) uc336stm.1 uc336stm.1 
ENSMUST00000340500.1 ENSMUSG00000137229 ENSMUST00000340500.1 ENSMUSG00000137229 (from geneSymbol) uc336stn.1 uc336stn.1 
ENSMUST00000340502.1 ENSMUSG00000137230 ENSMUST00000340502.1 ENSMUSG00000137230 (from geneSymbol) uc336stp.1 uc336stp.1 
ENSMUST00000340510.1 ENSMUSG00000137231 ENSMUST00000340510.1 ENSMUSG00000137231 (from geneSymbol) X56029 uc336stx.1 uc336stx.1 
ENSMUST00000340511.1 ENSMUSG00000137232 ENSMUST00000340511.1 ENSMUSG00000137232 (from geneSymbol) uc336sty.1 uc336sty.1 
ENSMUST00000340512.1 ENSMUSG00000137233 ENSMUST00000340512.1 ENSMUSG00000137233 (from geneSymbol) LF198254 uc336stz.1 uc336stz.1 
ENSMUST00000340513.1 ENSMUSG00000137234 ENSMUST00000340513.1 ENSMUSG00000137234 (from geneSymbol) uc336sua.1 uc336sua.1 
ENSMUST00000340514.1 ENSMUSG00000137235 ENSMUST00000340514.1 ENSMUSG00000137235 (from geneSymbol) uc336sub.1 uc336sub.1 
ENSMUST00000340521.1 ENSMUSG00000137236 ENSMUST00000340521.1 ENSMUSG00000137236 (from geneSymbol) uc336sui.1 uc336sui.1 
ENSMUST00000340527.1 4930484H19Rik ENSMUST00000340527.1 4930484H19Rik (from geneSymbol) AK015621 uc336suo.1 uc336suo.1 
ENSMUST00000340543.1 Gm32624 ENSMUST00000340543.1 Gm32624 (from geneSymbol) uc336sve.1 uc336sve.1 
ENSMUST00000340561.1 ENSMUSG00000137237 ENSMUST00000340561.1 ENSMUSG00000137237 (from geneSymbol) uc336svw.1 uc336svw.1 
ENSMUST00000340564.1 Hotair ENSMUST00000340564.1 Hotair (from geneSymbol) uc336svz.1 uc336svz.1 
ENSMUST00000340565.1 ENSMUSG00000137238 ENSMUST00000340565.1 ENSMUSG00000137238 (from geneSymbol) KY467737 uc336swa.1 uc336swa.1 
ENSMUST00000340566.1 ENSMUSG00000137239 ENSMUST00000340566.1 ENSMUSG00000137239 (from geneSymbol) uc336swb.1 uc336swb.1 
ENSMUST00000340567.1 ENSMUSG00000137240 ENSMUST00000340567.1 ENSMUSG00000137240 (from geneSymbol) uc336swc.1 uc336swc.1 
ENSMUST00000340568.1 ENSMUSG00000137241 ENSMUST00000340568.1 ENSMUSG00000137241 (from geneSymbol) uc336swd.1 uc336swd.1 
ENSMUST00000340569.1 ENSMUSG00000137242 ENSMUST00000340569.1 ENSMUSG00000137242 (from geneSymbol) uc336swe.1 uc336swe.1 
ENSMUST00000340592.1 ENSMUSG00000137243 ENSMUST00000340592.1 ENSMUSG00000137243 (from geneSymbol) uc336sxb.1 uc336sxb.1 
ENSMUST00000340593.1 BC028471 ENSMUST00000340593.1 BC028471 (from geneSymbol) AK030804 uc336sxc.1 uc336sxc.1 
ENSMUST00000340610.1 ENSMUSG00000137244 ENSMUST00000340610.1 ENSMUSG00000137244 (from geneSymbol) uc336sxt.1 uc336sxt.1 
ENSMUST00000340611.1 ENSMUSG00000137245 ENSMUST00000340611.1 ENSMUSG00000137245 (from geneSymbol) uc336sxu.1 uc336sxu.1 
ENSMUST00000340612.1 ENSMUSG00000137246 ENSMUST00000340612.1 ENSMUSG00000137246 (from geneSymbol) uc336sxv.1 uc336sxv.1 
ENSMUST00000340613.1 ENSMUSG00000137247 ENSMUST00000340613.1 ENSMUSG00000137247 (from geneSymbol) uc336sxw.1 uc336sxw.1 
ENSMUST00000340616.1 ENSMUSG00000137248 ENSMUST00000340616.1 ENSMUSG00000137248 (from geneSymbol) uc336sxz.1 uc336sxz.1 
ENSMUST00000340617.1 Gm57310 ENSMUST00000340617.1 Gm57310 (from geneSymbol) uc336sya.1 uc336sya.1 
ENSMUST00000340618.1 ENSMUSG00000137249 ENSMUST00000340618.1 ENSMUSG00000137249 (from geneSymbol) uc336syb.1 uc336syb.1 
ENSMUST00000340625.1 Gm14154 ENSMUST00000340625.1 Gm14154 (from geneSymbol) uc336syi.1 uc336syi.1 
ENSMUST00000340642.1 Gm13558 ENSMUST00000340642.1 Gm13558 (from geneSymbol) AK161816 uc336syz.1 uc336syz.1 
ENSMUST00000340650.1 ENSMUSG00000137250 ENSMUST00000340650.1 ENSMUSG00000137250 (from geneSymbol) uc336szg.1 uc336szg.1 
ENSMUST00000340653.1 ENSMUSG00000137251 ENSMUST00000340653.1 ENSMUSG00000137251 (from geneSymbol) uc336szj.1 uc336szj.1 
ENSMUST00000340659.1 ENSMUSG00000137252 ENSMUST00000340659.1 ENSMUSG00000137252 (from geneSymbol) AB339188 uc336szp.1 uc336szp.1 
ENSMUST00000340661.1 ENSMUSG00000137253 ENSMUST00000340661.1 ENSMUSG00000137253 (from geneSymbol) uc336szr.1 uc336szr.1 
ENSMUST00000340664.1 ENSMUSG00000137254 ENSMUST00000340664.1 ENSMUSG00000137254 (from geneSymbol) uc336szu.1 uc336szu.1 
ENSMUST00000340667.1 ENSMUSG00000137255 ENSMUST00000340667.1 ENSMUSG00000137255 (from geneSymbol) uc336szx.1 uc336szx.1 
ENSMUST00000340671.1 ENSMUSG00000137256 ENSMUST00000340671.1 ENSMUSG00000137256 (from geneSymbol) uc336tab.1 uc336tab.1 
ENSMUST00000340673.1 ENSMUSG00000137257 ENSMUST00000340673.1 ENSMUSG00000137257 (from geneSymbol) uc336tad.1 uc336tad.1 
ENSMUST00000340674.1 ENSMUSG00000137258 ENSMUST00000340674.1 ENSMUSG00000137258 (from geneSymbol) uc336tae.1 uc336tae.1 
ENSMUST00000340675.1 ENSMUSG00000137259 ENSMUST00000340675.1 ENSMUSG00000137259 (from geneSymbol) uc336taf.1 uc336taf.1 
ENSMUST00000340676.1 ENSMUSG00000137260 ENSMUST00000340676.1 ENSMUSG00000137260 (from geneSymbol) uc336tag.1 uc336tag.1 
ENSMUST00000340677.1 ENSMUSG00000137261 ENSMUST00000340677.1 ENSMUSG00000137261 (from geneSymbol) uc336tah.1 uc336tah.1 
ENSMUST00000340678.1 ENSMUSG00000137262 ENSMUST00000340678.1 ENSMUSG00000137262 (from geneSymbol) uc336tai.1 uc336tai.1 
ENSMUST00000340679.1 ENSMUSG00000137263 ENSMUST00000340679.1 ENSMUSG00000137263 (from geneSymbol) uc336taj.1 uc336taj.1 
ENSMUST00000340682.1 ENSMUSG00000137264 ENSMUST00000340682.1 ENSMUSG00000137264 (from geneSymbol) uc336tam.1 uc336tam.1 
ENSMUST00000340688.1 Gm47352 ENSMUST00000340688.1 Gm47352 (from geneSymbol) uc336tas.1 uc336tas.1 
ENSMUST00000340691.1 ENSMUSG00000121356 ENSMUST00000340691.1 ENSMUSG00000121356 (from geneSymbol) uc336tav.1 uc336tav.1 
ENSMUST00000340693.1 Gm16223 ENSMUST00000340693.1 Gm16223 (from geneSymbol) AK035725 uc336tax.1 uc336tax.1 
ENSMUST00000340700.1 Gm52054 ENSMUST00000340700.1 Gm52054 (from geneSymbol) uc336tbe.1 uc336tbe.1 
ENSMUST00000340705.1 ENSMUSG00000137265 ENSMUST00000340705.1 ENSMUSG00000137265 (from geneSymbol) uc336tbj.1 uc336tbj.1 
ENSMUST00000340706.1 ENSMUSG00000137266 ENSMUST00000340706.1 ENSMUSG00000137266 (from geneSymbol) uc336tbk.1 uc336tbk.1 
ENSMUST00000340707.1 ENSMUSG00000137267 ENSMUST00000340707.1 ENSMUSG00000137267 (from geneSymbol) uc336tbl.1 uc336tbl.1 
ENSMUST00000340708.1 ENSMUSG00000137268 ENSMUST00000340708.1 ENSMUSG00000137268 (from geneSymbol) uc336tbm.1 uc336tbm.1 
ENSMUST00000340710.1 ENSMUSG00000137269 ENSMUST00000340710.1 ENSMUSG00000137269 (from geneSymbol) uc336tbo.1 uc336tbo.1 
ENSMUST00000340711.1 4930477G07Rik ENSMUST00000340711.1 4930477G07Rik (from geneSymbol) AK019645 uc336tbp.1 uc336tbp.1 
ENSMUST00000340714.1 ENSMUSG00000137270 ENSMUST00000340714.1 ENSMUSG00000137270 (from geneSymbol) uc336tbs.1 uc336tbs.1 
ENSMUST00000340718.1 ENSMUSG00000137271 ENSMUST00000340718.1 ENSMUSG00000137271 (from geneSymbol) uc336tbw.1 uc336tbw.1 
ENSMUST00000340719.1 Gm45490 ENSMUST00000340719.1 Gm45490 (from geneSymbol) uc336tbx.1 uc336tbx.1 
ENSMUST00000340722.1 ENSMUSG00000137272 ENSMUST00000340722.1 ENSMUSG00000137272 (from geneSymbol) uc336tca.1 uc336tca.1 
ENSMUST00000340724.1 ENSMUSG00000137273 ENSMUST00000340724.1 ENSMUSG00000137273 (from geneSymbol) uc336tcc.1 uc336tcc.1 
ENSMUST00000340725.1 ENSMUSG00000137274 ENSMUST00000340725.1 ENSMUSG00000137274 (from geneSymbol) uc336tcd.1 uc336tcd.1 
ENSMUST00000340727.1 ENSMUSG00000137275 ENSMUST00000340727.1 ENSMUSG00000137275 (from geneSymbol) uc336tcf.1 uc336tcf.1 
ENSMUST00000340734.1 ENSMUSG00000137276 ENSMUST00000340734.1 ENSMUSG00000137276 (from geneSymbol) uc336tcm.1 uc336tcm.1 
ENSMUST00000340735.1 ENSMUSG00000137277 ENSMUST00000340735.1 ENSMUSG00000137277 (from geneSymbol) uc336tcn.1 uc336tcn.1 
ENSMUST00000340737.1 ENSMUSG00000137278 ENSMUST00000340737.1 ENSMUSG00000137278 (from geneSymbol) uc336tcp.1 uc336tcp.1 
ENSMUST00000340739.1 ENSMUSG00000137279 ENSMUST00000340739.1 ENSMUSG00000137279 (from geneSymbol) uc336tcr.1 uc336tcr.1 
ENSMUST00000340741.1 ENSMUSG00000137280 ENSMUST00000340741.1 ENSMUSG00000137280 (from geneSymbol) uc336tct.1 uc336tct.1 
ENSMUST00000340751.1 Gm32461 ENSMUST00000340751.1 Gm32461 (from geneSymbol) uc336tdd.1 uc336tdd.1 
ENSMUST00000340801.1 ENSMUSG00000137281 ENSMUST00000340801.1 ENSMUSG00000137281 (from geneSymbol) uc336tfb.1 uc336tfb.1 
ENSMUST00000340824.1 ENSMUSG00000137282 ENSMUST00000340824.1 ENSMUSG00000137282 (from geneSymbol) uc336tfx.1 uc336tfx.1 
ENSMUST00000340826.1 ENSMUSG00000137283 ENSMUST00000340826.1 ENSMUSG00000137283 (from geneSymbol) uc336tfz.1 uc336tfz.1 
ENSMUST00000340827.1 ENSMUSG00000137284 ENSMUST00000340827.1 ENSMUSG00000137284 (from geneSymbol) uc336tga.1 uc336tga.1 
ENSMUST00000340828.1 ENSMUSG00000137285 ENSMUST00000340828.1 ENSMUSG00000137285 (from geneSymbol) uc336tgb.1 uc336tgb.1 
ENSMUST00000340830.1 ENSMUSG00000137286 ENSMUST00000340830.1 ENSMUSG00000137286 (from geneSymbol) uc336tgd.1 uc336tgd.1 
ENSMUST00000340831.1 ENSMUSG00000137287 ENSMUST00000340831.1 ENSMUSG00000137287 (from geneSymbol) uc336tge.1 uc336tge.1 
ENSMUST00000340832.1 Gm57300 ENSMUST00000340832.1 Gm57300 (from geneSymbol) uc336tgf.1 uc336tgf.1 
ENSMUST00000340837.1 ENSMUSG00000137288 ENSMUST00000340837.1 ENSMUSG00000137288 (from geneSymbol) uc336tgk.1 uc336tgk.1 
ENSMUST00000340840.1 ENSMUSG00000137289 ENSMUST00000340840.1 ENSMUSG00000137289 (from geneSymbol) uc336tgn.1 uc336tgn.1 
ENSMUST00000340841.1 ENSMUSG00000137290 ENSMUST00000340841.1 ENSMUSG00000137290 (from geneSymbol) uc336tgo.1 uc336tgo.1 
ENSMUST00000340845.1 ENSMUSG00000137291 ENSMUST00000340845.1 ENSMUSG00000137291 (from geneSymbol) uc336tgs.1 uc336tgs.1 
ENSMUST00000340848.1 ENSMUSG00000137292 ENSMUST00000340848.1 ENSMUSG00000137292 (from geneSymbol) AK132883 uc336tgu.1 uc336tgu.1 
ENSMUST00000340851.1 Gm12746 ENSMUST00000340851.1 Gm12746 (from geneSymbol) AK137110 uc336tgx.1 uc336tgx.1 
ENSMUST00000340866.1 ENSMUSG00000137293 ENSMUST00000340866.1 ENSMUSG00000137293 (from geneSymbol) uc336thm.1 uc336thm.1 
ENSMUST00000340867.1 ENSMUSG00000137294 ENSMUST00000340867.1 ENSMUSG00000137294 (from geneSymbol) uc336thn.1 uc336thn.1 
ENSMUST00000340870.1 B230311B06Rik ENSMUST00000340870.1 B230311B06Rik (from geneSymbol) AK045786 uc336thq.1 uc336thq.1 
ENSMUST00000340900.1 ENSMUSG00000137295 ENSMUST00000340900.1 ENSMUSG00000137295 (from geneSymbol) uc336tiu.1 uc336tiu.1 
ENSMUST00000340901.1 ENSMUSG00000137296 ENSMUST00000340901.1 ENSMUSG00000137296 (from geneSymbol) uc336tiv.1 uc336tiv.1 
ENSMUST00000340902.1 ENSMUSG00000137297 ENSMUST00000340902.1 ENSMUSG00000137297 (from geneSymbol) uc336tiw.1 uc336tiw.1 
ENSMUST00000340903.1 ENSMUSG00000137298 ENSMUST00000340903.1 ENSMUSG00000137298 (from geneSymbol) uc336tix.1 uc336tix.1 
ENSMUST00000340914.1 ENSMUSG00000137299 ENSMUST00000340914.1 ENSMUSG00000137299 (from geneSymbol) uc336tji.1 uc336tji.1 
ENSMUST00000340915.1 ENSMUSG00000137300 ENSMUST00000340915.1 ENSMUSG00000137300 (from geneSymbol) uc336tjj.1 uc336tjj.1 
ENSMUST00000340917.1 ENSMUSG00000137301 ENSMUST00000340917.1 ENSMUSG00000137301 (from geneSymbol) uc336tjl.1 uc336tjl.1 
ENSMUST00000340920.1 ENSMUSG00000137302 ENSMUST00000340920.1 ENSMUSG00000137302 (from geneSymbol) uc336tjo.1 uc336tjo.1 
ENSMUST00000340921.1 ENSMUSG00000137303 ENSMUST00000340921.1 ENSMUSG00000137303 (from geneSymbol) uc336tjp.1 uc336tjp.1 
ENSMUST00000340922.1 ENSMUSG00000137304 ENSMUST00000340922.1 ENSMUSG00000137304 (from geneSymbol) uc336tjq.1 uc336tjq.1 
ENSMUST00000340924.1 ENSMUSG00000137305 ENSMUST00000340924.1 ENSMUSG00000137305 (from geneSymbol) uc336tjs.1 uc336tjs.1 
ENSMUST00000340927.1 ENSMUSG00000137306 ENSMUST00000340927.1 ENSMUSG00000137306 (from geneSymbol) uc336tjv.1 uc336tjv.1 
ENSMUST00000340928.1 D730003K21Rik ENSMUST00000340928.1 D730003K21Rik (from geneSymbol) AK021326 uc336tjw.1 uc336tjw.1 
ENSMUST00000340957.1 ENSMUSG00000137307 ENSMUST00000340957.1 ENSMUSG00000137307 (from geneSymbol) uc336tkz.1 uc336tkz.1 
ENSMUST00000340958.1 ENSMUSG00000137308 ENSMUST00000340958.1 ENSMUSG00000137308 (from geneSymbol) uc336tla.1 uc336tla.1 
ENSMUST00000340960.1 ENSMUSG00000137309 ENSMUST00000340960.1 ENSMUSG00000137309 (from geneSymbol) uc336tlc.1 uc336tlc.1 
ENSMUST00000340962.1 ENSMUSG00000137310 ENSMUST00000340962.1 ENSMUSG00000137310 (from geneSymbol) uc336tle.1 uc336tle.1 
ENSMUST00000340963.1 Gm42209 ENSMUST00000340963.1 Gm42209 (from geneSymbol) uc336tlf.1 uc336tlf.1 
ENSMUST00000340980.1 ENSMUSG00000137311 ENSMUST00000340980.1 ENSMUSG00000137311 (from geneSymbol) uc336tlw.1 uc336tlw.1 
ENSMUST00000340984.1 ENSMUSG00000137312 ENSMUST00000340984.1 ENSMUSG00000137312 (from geneSymbol) uc336tma.1 uc336tma.1 
ENSMUST00000340986.1 ENSMUSG00000137313 ENSMUST00000340986.1 ENSMUSG00000137313 (from geneSymbol) uc336tmc.1 uc336tmc.1 
ENSMUST00000340988.1 ENSMUSG00000137314 ENSMUST00000340988.1 ENSMUSG00000137314 (from geneSymbol) uc336tme.1 uc336tme.1 
ENSMUST00000341007.1 ENSMUSG00000137315 ENSMUST00000341007.1 ENSMUSG00000137315 (from geneSymbol) uc336tmx.1 uc336tmx.1 
ENSMUST00000341008.1 ENSMUSG00000137316 ENSMUST00000341008.1 ENSMUSG00000137316 (from geneSymbol) uc336tmy.1 uc336tmy.1 
ENSMUST00000341009.1 ENSMUSG00000137317 ENSMUST00000341009.1 ENSMUSG00000137317 (from geneSymbol) uc336tmz.1 uc336tmz.1 
ENSMUST00000341011.1 Gm12256 ENSMUST00000341011.1 Gm12256 (from geneSymbol) uc336tnb.1 uc336tnb.1 
ENSMUST00000341018.1 ENSMUSG00000137318 ENSMUST00000341018.1 ENSMUSG00000137318 (from geneSymbol) uc336tni.1 uc336tni.1 
ENSMUST00000341019.1 ENSMUSG00000137319 ENSMUST00000341019.1 ENSMUSG00000137319 (from geneSymbol) uc336tnj.1 uc336tnj.1 
ENSMUST00000341025.1 ENSMUSG00000137320 ENSMUST00000341025.1 ENSMUSG00000137320 (from geneSymbol) uc336tnp.1 uc336tnp.1 
ENSMUST00000341029.1 Platr28 ENSMUST00000341029.1 Platr28 (from geneSymbol) AY512917 uc336tns.1 uc336tns.1 
ENSMUST00000341035.1 ENSMUSG00000137322 ENSMUST00000341035.1 ENSMUSG00000137322 (from geneSymbol) uc336tnx.1 uc336tnx.1 
ENSMUST00000341036.1 ENSMUSG00000137323 ENSMUST00000341036.1 ENSMUSG00000137323 (from geneSymbol) uc336tny.1 uc336tny.1 
ENSMUST00000341039.1 1700037F03Rik ENSMUST00000341039.1 1700037F03Rik (from geneSymbol) AK006620 uc336tob.1 uc336tob.1 
ENSMUST00000341100.1 ENSMUSG00000137324 ENSMUST00000341100.1 ENSMUSG00000137324 (from geneSymbol) uc336tqj.1 uc336tqj.1 
ENSMUST00000341102.1 ENSMUSG00000137325 ENSMUST00000341102.1 ENSMUSG00000137325 (from geneSymbol) uc336tql.1 uc336tql.1 
ENSMUST00000341103.1 Gm56757 ENSMUST00000341103.1 Gm56757 (from geneSymbol) uc336tqm.1 uc336tqm.1 
ENSMUST00000341111.1 ENSMUSG00000137326 ENSMUST00000341111.1 ENSMUSG00000137326 (from geneSymbol) uc336tqu.1 uc336tqu.1 
ENSMUST00000341114.1 ENSMUSG00000137327 ENSMUST00000341114.1 ENSMUSG00000137327 (from geneSymbol) uc336tqx.1 uc336tqx.1 
ENSMUST00000341117.1 Gm57074 ENSMUST00000341117.1 Gm57074 (from geneSymbol) uc336tra.1 uc336tra.1 
ENSMUST00000341127.1 ENSMUSG00000137329 ENSMUST00000341127.1 ENSMUSG00000137329 (from geneSymbol) uc336trk.1 uc336trk.1 
ENSMUST00000341129.1 ENSMUSG00000137330 ENSMUST00000341129.1 ENSMUSG00000137330 (from geneSymbol) uc336trm.1 uc336trm.1 
ENSMUST00000341138.1 ENSMUSG00000137331 ENSMUST00000341138.1 ENSMUSG00000137331 (from geneSymbol) uc336trv.1 uc336trv.1 
ENSMUST00000341140.1 ENSMUSG00000137332 ENSMUST00000341140.1 ENSMUSG00000137332 (from geneSymbol) uc336trx.1 uc336trx.1 
ENSMUST00000341146.1 ENSMUSG00000137333 ENSMUST00000341146.1 ENSMUSG00000137333 (from geneSymbol) uc336tsd.1 uc336tsd.1 
ENSMUST00000341148.1 Gm49497 ENSMUST00000341148.1 Gm49497 (from geneSymbol) uc336tsf.1 uc336tsf.1 
ENSMUST00000341157.1 ENSMUSG00000137334 ENSMUST00000341157.1 ENSMUSG00000137334 (from geneSymbol) uc336tso.1 uc336tso.1 
ENSMUST00000341159.1 Gm46633 ENSMUST00000341159.1 Gm46633 (from geneSymbol) uc336tsq.1 uc336tsq.1 
ENSMUST00000341164.1 ENSMUSG00000121511 ENSMUST00000341164.1 ENSMUSG00000121511 (from geneSymbol) AK054052 uc336tsv.1 uc336tsv.1 
ENSMUST00000341169.1 ENSMUSG00000137335 ENSMUST00000341169.1 ENSMUSG00000137335 (from geneSymbol) uc336tta.1 uc336tta.1 
ENSMUST00000341173.1 ENSMUSG00000137336 ENSMUST00000341173.1 ENSMUSG00000137336 (from geneSymbol) uc336tte.1 uc336tte.1 
ENSMUST00000341175.1 5730412P04Rik ENSMUST00000341175.1 5730412P04Rik (from geneSymbol) AK017555 uc336ttg.1 uc336ttg.1 
ENSMUST00000341189.1 ENSMUSG00000137337 ENSMUST00000341189.1 ENSMUSG00000137337 (from geneSymbol) uc336ttu.1 uc336ttu.1 
ENSMUST00000341190.1 Gm34350 ENSMUST00000341190.1 Gm34350 (from geneSymbol) uc336ttv.1 uc336ttv.1 
ENSMUST00000341191.1 ENSMUSG00000137338 ENSMUST00000341191.1 ENSMUSG00000137338 (from geneSymbol) uc336ttw.1 uc336ttw.1 
ENSMUST00000341193.1 ENSMUSG00000137339 ENSMUST00000341193.1 ENSMUSG00000137339 (from geneSymbol) uc336tty.1 uc336tty.1 
ENSMUST00000341196.1 Gm30082 ENSMUST00000341196.1 Gm30082 (from geneSymbol) uc336tub.1 uc336tub.1 
ENSMUST00000341202.1 ENSMUSG00000137340 ENSMUST00000341202.1 ENSMUSG00000137340 (from geneSymbol) BC048561 uc336tuh.1 uc336tuh.1 
ENSMUST00000341203.1 ENSMUSG00000137341 ENSMUST00000341203.1 ENSMUSG00000137341 (from geneSymbol) uc336tui.1 uc336tui.1 
ENSMUST00000341212.1 ENSMUSG00000137342 ENSMUST00000341212.1 predicted gene, 52329 (from RefSeq NR_166729.1) NR_166729 uc336tur.1 uc336tur.1 
ENSMUST00000341213.1 ENSMUSG00000137343 ENSMUST00000341213.1 ENSMUSG00000137343 (from geneSymbol) uc336tus.1 uc336tus.1 
ENSMUST00000341214.1 ENSMUSG00000137344 ENSMUST00000341214.1 ENSMUSG00000137344 (from geneSymbol) uc336tut.1 uc336tut.1 
ENSMUST00000341215.1 ENSMUSG00000137345 ENSMUST00000341215.1 ENSMUSG00000137345 (from geneSymbol) uc336tuu.1 uc336tuu.1 
ENSMUST00000341225.1 ENSMUSG00000137347 ENSMUST00000341225.1 ENSMUSG00000137347 (from geneSymbol) KY467658 uc336tvd.1 uc336tvd.1 
ENSMUST00000341262.1 ENSMUSG00000137348 ENSMUST00000341262.1 ENSMUSG00000137348 (from geneSymbol) uc336two.1 uc336two.1 
ENSMUST00000341263.1 ENSMUSG00000137349 ENSMUST00000341263.1 ENSMUSG00000137349 (from geneSymbol) uc336twp.1 uc336twp.1 
ENSMUST00000341268.1 ENSMUSG00000137350 ENSMUST00000341268.1 ENSMUSG00000137350 (from geneSymbol) uc336twu.1 uc336twu.1 
ENSMUST00000341273.1 Snhg17 ENSMUST00000341273.1 Snhg17 (from geneSymbol) AK046044 uc336twz.1 uc336twz.1 
ENSMUST00000341378.1 Gm8098 ENSMUST00000341378.1 predicted gene 8098, transcript variant 3 (from RefSeq NR_168039.1) NR_168039 uc336uax.1 uc336uax.1 
ENSMUST00000341387.1 ENSMUSG00000137351 ENSMUST00000341387.1 ENSMUSG00000137351 (from geneSymbol) uc336ubg.1 uc336ubg.1 
ENSMUST00000341388.1 ENSMUSG00000137352 ENSMUST00000341388.1 ENSMUSG00000137352 (from geneSymbol) uc336ubh.1 uc336ubh.1 
ENSMUST00000341395.1 ENSMUSG00000137353 ENSMUST00000341395.1 ENSMUSG00000137353 (from geneSymbol) uc336ubo.1 uc336ubo.1 
ENSMUST00000341398.1 Gm13058 ENSMUST00000341398.1 predicted gene 13058 (from RefSeq NR_171057.1) NR_171057 uc336ubr.1 uc336ubr.1 
ENSMUST00000341400.1 Gm34809 ENSMUST00000341400.1 Gm34809 (from geneSymbol) uc336ubt.1 uc336ubt.1 
ENSMUST00000341428.1 ENSMUSG00000137355 ENSMUST00000341428.1 ENSMUSG00000137355 (from geneSymbol) uc336ucv.1 uc336ucv.1 
ENSMUST00000341435.1 ENSMUSG00000137356 ENSMUST00000341435.1 ENSMUSG00000137356 (from geneSymbol) uc336udc.1 uc336udc.1 
ENSMUST00000341437.1 ENSMUSG00000137357 ENSMUST00000341437.1 ENSMUSG00000137357 (from geneSymbol) uc336ude.1 uc336ude.1 
ENSMUST00000341440.1 ENSMUSG00000137358 ENSMUST00000341440.1 ENSMUSG00000137358 (from geneSymbol) uc336udh.1 uc336udh.1 
ENSMUST00000341442.1 ENSMUSG00000137359 ENSMUST00000341442.1 ENSMUSG00000137359 (from geneSymbol) uc336udj.1 uc336udj.1 
ENSMUST00000341443.1 ENSMUSG00000137360 ENSMUST00000341443.1 ENSMUSG00000137360 (from geneSymbol) uc336udk.1 uc336udk.1 
ENSMUST00000341444.1 ENSMUSG00000137361 ENSMUST00000341444.1 ENSMUSG00000137361 (from geneSymbol) uc336udl.1 uc336udl.1 
ENSMUST00000341451.1 ENSMUSG00000137362 ENSMUST00000341451.1 ENSMUSG00000137362 (from geneSymbol) uc336udr.1 uc336udr.1 
ENSMUST00000341452.1 ENSMUSG00000137363 ENSMUST00000341452.1 ENSMUSG00000137363 (from geneSymbol) uc336uds.1 uc336uds.1 
ENSMUST00000341457.1 ENSMUSG00000137364 ENSMUST00000341457.1 ENSMUSG00000137364 (from geneSymbol) uc336udx.1 uc336udx.1 
ENSMUST00000341463.1 ENSMUSG00000137365 ENSMUST00000341463.1 ENSMUSG00000137365 (from geneSymbol) uc336ued.1 uc336ued.1 
ENSMUST00000341465.1 ENSMUSG00000137366 ENSMUST00000341465.1 ENSMUSG00000137366 (from geneSymbol) uc336uef.1 uc336uef.1 
ENSMUST00000341466.1 Gm31125 ENSMUST00000341466.1 Gm31125 (from geneSymbol) uc336ueg.1 uc336ueg.1 
ENSMUST00000341469.1 Gm28371 ENSMUST00000341469.1 predicted gene 28371 (from RefSeq NR_164194.1) NR_164194 uc336uej.1 uc336uej.1 
ENSMUST00000341506.1 Gm36017 ENSMUST00000341506.1 Gm36017 (from geneSymbol) AK076918 uc336ufu.1 uc336ufu.1 
ENSMUST00000341510.1 ENSMUSG00000121480 ENSMUST00000341510.1 ENSMUSG00000121480 (from geneSymbol) AK076965 uc336ufy.1 uc336ufy.1 
ENSMUST00000341524.1 ENSMUSG00000137368 ENSMUST00000341524.1 ENSMUSG00000137368 (from geneSymbol) uc336ugm.1 uc336ugm.1 
ENSMUST00000341528.1 4930573O16Rik ENSMUST00000341528.1 RIKEN cDNA 4930573O16 gene (from RefSeq NR_040620.1) NR_040620 uc336ugq.1 uc336ugq.1 
ENSMUST00000341530.1 ENSMUSG00000137370 ENSMUST00000341530.1 ENSMUSG00000137370 (from geneSymbol) uc336ugs.1 uc336ugs.1 
ENSMUST00000341532.1 Gm44097 ENSMUST00000341532.1 Gm44097 (from geneSymbol) uc336ugu.1 uc336ugu.1 
ENSMUST00000341536.1 ENSMUSG00000137371 ENSMUST00000341536.1 ENSMUSG00000137371 (from geneSymbol) uc336ugy.1 uc336ugy.1 
ENSMUST00000341538.1 ENSMUSG00000137372 ENSMUST00000341538.1 ENSMUSG00000137372 (from geneSymbol) uc336ugz.1 uc336ugz.1 
ENSMUST00000341540.1 ENSMUSG00000137373 ENSMUST00000341540.1 ENSMUSG00000137373 (from geneSymbol) uc336uhb.1 uc336uhb.1 
ENSMUST00000341541.1 ENSMUSG00000137374 ENSMUST00000341541.1 ENSMUSG00000137374 (from geneSymbol) uc336uhc.1 uc336uhc.1 
ENSMUST00000341542.1 ENSMUSG00000137375 ENSMUST00000341542.1 ENSMUSG00000137375 (from geneSymbol) uc336uhd.1 uc336uhd.1 
ENSMUST00000341544.1 ENSMUSG00000137376 ENSMUST00000341544.1 ENSMUSG00000137376 (from geneSymbol) uc336uhf.1 uc336uhf.1 
ENSMUST00000341545.1 ENSMUSG00000137377 ENSMUST00000341545.1 ENSMUSG00000137377 (from geneSymbol) uc336uhg.1 uc336uhg.1 
ENSMUST00000341546.1 ENSMUSG00000137378 ENSMUST00000341546.1 ENSMUSG00000137378 (from geneSymbol) uc336uhh.1 uc336uhh.1 
ENSMUST00000341547.1 9330171B17Rik ENSMUST00000341547.1 9330171B17Rik (from geneSymbol) uc336uhi.1 uc336uhi.1 
ENSMUST00000341550.1 ENSMUSG00000137379 ENSMUST00000341550.1 ENSMUSG00000137379 (from geneSymbol) uc336uhl.1 uc336uhl.1 
ENSMUST00000341552.1 ENSMUSG00000137380 ENSMUST00000341552.1 ENSMUSG00000137380 (from geneSymbol) uc336uhn.1 uc336uhn.1 
ENSMUST00000341556.1 ENSMUSG00000137381 ENSMUST00000341556.1 ENSMUSG00000137381 (from geneSymbol) uc336uhr.1 uc336uhr.1 
ENSMUST00000341559.1 ENSMUSG00000137382 ENSMUST00000341559.1 ENSMUSG00000137382 (from geneSymbol) uc336uhu.1 uc336uhu.1 
ENSMUST00000341565.1 ENSMUSG00000137383 ENSMUST00000341565.1 ENSMUSG00000137383 (from geneSymbol) uc336uia.1 uc336uia.1 
ENSMUST00000341566.1 1700008C04Rik ENSMUST00000341566.1 1700008C04Rik (from geneSymbol) AK005755 uc336uib.1 uc336uib.1 
ENSMUST00000341580.1 ENSMUSG00000137385 ENSMUST00000341580.1 ENSMUSG00000137385 (from geneSymbol) uc336uio.1 uc336uio.1 
ENSMUST00000341587.1 ENSMUSG00000137386 ENSMUST00000341587.1 ENSMUSG00000137386 (from geneSymbol) uc336uiv.1 uc336uiv.1 
ENSMUST00000341588.1 ENSMUSG00000137387 ENSMUST00000341588.1 ENSMUSG00000137387 (from geneSymbol) uc336uiw.1 uc336uiw.1 
ENSMUST00000341596.1 ENSMUSG00000137388 ENSMUST00000341596.1 ENSMUSG00000137388 (from geneSymbol) uc336uje.1 uc336uje.1 
ENSMUST00000341603.1 ENSMUSG00000137389 ENSMUST00000341603.1 ENSMUSG00000137389 (from geneSymbol) uc336ujl.1 uc336ujl.1 
ENSMUST00000341609.1 ENSMUSG00000137390 ENSMUST00000341609.1 ENSMUSG00000137390 (from geneSymbol) uc336ujr.1 uc336ujr.1 
ENSMUST00000341610.1 ENSMUSG00000137391 ENSMUST00000341610.1 ENSMUSG00000137391 (from geneSymbol) uc336ujs.1 uc336ujs.1 
ENSMUST00000341614.1 ENSMUSG00000137392 ENSMUST00000341614.1 ENSMUSG00000137392 (from geneSymbol) uc336ujv.1 uc336ujv.1 
ENSMUST00000341617.1 ENSMUSG00000137394 ENSMUST00000341617.1 ENSMUSG00000137394 (from geneSymbol) uc336ujx.1 uc336ujx.1 
ENSMUST00000341618.1 ENSMUSG00000137395 ENSMUST00000341618.1 ENSMUSG00000137395 (from geneSymbol) uc336ujy.1 uc336ujy.1 
ENSMUST00000341619.1 ENSMUSG00000137396 ENSMUST00000341619.1 ENSMUSG00000137396 (from geneSymbol) uc336ujz.1 uc336ujz.1 
ENSMUST00000341621.1 ENSMUSG00000137397 ENSMUST00000341621.1 ENSMUSG00000137397 (from geneSymbol) uc336ukb.1 uc336ukb.1 
ENSMUST00000341626.1 ENSMUSG00000137398 ENSMUST00000341626.1 ENSMUSG00000137398 (from geneSymbol) uc336ukg.1 uc336ukg.1 
ENSMUST00000341627.1 ENSMUSG00000137399 ENSMUST00000341627.1 ENSMUSG00000137399 (from geneSymbol) uc336ukh.1 uc336ukh.1 
ENSMUST00000341629.1 ENSMUSG00000137400 ENSMUST00000341629.1 ENSMUSG00000137400 (from geneSymbol) uc336ukj.1 uc336ukj.1 
ENSMUST00000341630.1 ENSMUSG00000137401 ENSMUST00000341630.1 ENSMUSG00000137401 (from geneSymbol) uc336ukk.1 uc336ukk.1 
ENSMUST00000341631.1 ENSMUSG00000137402 ENSMUST00000341631.1 ENSMUSG00000137402 (from geneSymbol) uc336ukl.1 uc336ukl.1 
ENSMUST00000341632.1 ENSMUSG00000137403 ENSMUST00000341632.1 ENSMUSG00000137403 (from geneSymbol) uc336ukm.1 uc336ukm.1 
ENSMUST00000341650.1 ENSMUSG00000137405 ENSMUST00000341650.1 ENSMUSG00000137405 (from geneSymbol) uc336uld.1 uc336uld.1 
ENSMUST00000341656.1 ENSMUSG00000137406 ENSMUST00000341656.1 ENSMUSG00000137406 (from geneSymbol) uc336ulj.1 uc336ulj.1 
ENSMUST00000341661.1 ENSMUSG00000137407 ENSMUST00000341661.1 ENSMUSG00000137407 (from geneSymbol) uc336ulo.1 uc336ulo.1 
ENSMUST00000341662.1 ENSMUSG00000137408 ENSMUST00000341662.1 ENSMUSG00000137408 (from geneSymbol) uc336ulp.1 uc336ulp.1 
ENSMUST00000341663.1 ENSMUSG00000137409 ENSMUST00000341663.1 ENSMUSG00000137409 (from geneSymbol) uc336ulq.1 uc336ulq.1 
ENSMUST00000341664.1 ENSMUSG00000137410 ENSMUST00000341664.1 ENSMUSG00000137410 (from geneSymbol) uc336ulr.1 uc336ulr.1 
ENSMUST00000341666.1 ENSMUSG00000137411 ENSMUST00000341666.1 ENSMUSG00000137411 (from geneSymbol) uc336ult.1 uc336ult.1 
ENSMUST00000341667.1 ENSMUSG00000137412 ENSMUST00000341667.1 ENSMUSG00000137412 (from geneSymbol) uc336ulu.1 uc336ulu.1 
ENSMUST00000341669.1 ENSMUSG00000137413 ENSMUST00000341669.1 ENSMUSG00000137413 (from geneSymbol) uc336ulw.1 uc336ulw.1 
ENSMUST00000341673.1 ENSMUSG00000137414 ENSMUST00000341673.1 ENSMUSG00000137414 (from geneSymbol) uc336uma.1 uc336uma.1 
ENSMUST00000341677.1 ENSMUSG00000137415 ENSMUST00000341677.1 ENSMUSG00000137415 (from geneSymbol) uc336ume.1 uc336ume.1 
ENSMUST00000341678.1 ENSMUSG00000137416 ENSMUST00000341678.1 ENSMUSG00000137416 (from geneSymbol) uc336umf.1 uc336umf.1 
ENSMUST00000341679.1 ENSMUSG00000137417 ENSMUST00000341679.1 ENSMUSG00000137417 (from geneSymbol) uc336umg.1 uc336umg.1 
ENSMUST00000341686.1 Gm13522 ENSMUST00000341686.1 Gm13522 (from geneSymbol) KY467859 uc336umn.1 uc336umn.1 
ENSMUST00000341734.1 ENSMUSG00000137419 ENSMUST00000341734.1 ENSMUSG00000137419 (from geneSymbol) uc336uoi.1 uc336uoi.1 
ENSMUST00000341735.1 ENSMUSG00000137420 ENSMUST00000341735.1 ENSMUSG00000137420 (from geneSymbol) uc336uoj.1 uc336uoj.1 
ENSMUST00000341736.1 ENSMUSG00000137421 ENSMUST00000341736.1 ENSMUSG00000137421 (from geneSymbol) uc336uok.1 uc336uok.1 
ENSMUST00000341738.1 ENSMUSG00000137422 ENSMUST00000341738.1 ENSMUSG00000137422 (from geneSymbol) uc336uom.1 uc336uom.1 
ENSMUST00000341739.1 ENSMUSG00000137423 ENSMUST00000341739.1 ENSMUSG00000137423 (from geneSymbol) uc336uon.1 uc336uon.1 
ENSMUST00000341740.1 ENSMUSG00000137424 ENSMUST00000341740.1 ENSMUSG00000137424 (from geneSymbol) uc336uoo.1 uc336uoo.1 
ENSMUST00000341746.1 ENSMUSG00000137425 ENSMUST00000341746.1 ENSMUSG00000137425 (from geneSymbol) uc336uou.1 uc336uou.1 
ENSMUST00000341757.1 ENSMUSG00000137426 ENSMUST00000341757.1 ENSMUSG00000137426 (from geneSymbol) uc336upf.1 uc336upf.1 
ENSMUST00000341758.1 ENSMUSG00000137427 ENSMUST00000341758.1 ENSMUSG00000137427 (from geneSymbol) uc336upg.1 uc336upg.1 
ENSMUST00000341759.1 ENSMUSG00000137428 ENSMUST00000341759.1 ENSMUSG00000137428 (from geneSymbol) uc336uph.1 uc336uph.1 
ENSMUST00000341760.1 ENSMUSG00000137429 ENSMUST00000341760.1 ENSMUSG00000137429 (from geneSymbol) uc336upi.1 uc336upi.1 
ENSMUST00000341761.1 ENSMUSG00000137430 ENSMUST00000341761.1 ENSMUSG00000137430 (from geneSymbol) uc336upj.1 uc336upj.1 
ENSMUST00000341762.1 Gm40421 ENSMUST00000341762.1 Gm40421 (from geneSymbol) AK131776 uc336upk.1 uc336upk.1 
ENSMUST00000341792.1 ENSMUSG00000137431 ENSMUST00000341792.1 ENSMUSG00000137431 (from geneSymbol) uc336uqo.1 uc336uqo.1 
ENSMUST00000341798.1 ENSMUSG00000137432 ENSMUST00000341798.1 ENSMUSG00000137432 (from geneSymbol) uc336uqu.1 uc336uqu.1 
ENSMUST00000341803.1 ENSMUSG00000137433 ENSMUST00000341803.1 ENSMUSG00000137433 (from geneSymbol) uc336uqz.1 uc336uqz.1 
ENSMUST00000341804.1 ENSMUSG00000137434 ENSMUST00000341804.1 ENSMUSG00000137434 (from geneSymbol) uc336ura.1 uc336ura.1 
ENSMUST00000341805.1 Gm57787 ENSMUST00000341805.1 Gm57787 (from geneSymbol) AK136817 uc336urb.1 uc336urb.1 
ENSMUST00000341807.1 ENSMUSG00000137435 ENSMUST00000341807.1 ENSMUSG00000137435 (from geneSymbol) uc336urd.1 uc336urd.1 
ENSMUST00000341808.1 ENSMUSG00000137436 ENSMUST00000341808.1 ENSMUSG00000137436 (from geneSymbol) uc336ure.1 uc336ure.1 
ENSMUST00000341813.1 ENSMUSG00000137437 ENSMUST00000341813.1 ENSMUSG00000137437 (from geneSymbol) uc336urj.1 uc336urj.1 
ENSMUST00000341836.1 ENSMUSG00000137438 ENSMUST00000341836.1 ENSMUSG00000137438 (from geneSymbol) AK029648 uc336usg.1 uc336usg.1 
ENSMUST00000341843.1 ENSMUSG00000137439 ENSMUST00000341843.1 ENSMUSG00000137439 (from geneSymbol) uc336usn.1 uc336usn.1 
ENSMUST00000341844.1 ENSMUSG00000137440 ENSMUST00000341844.1 ENSMUSG00000137440 (from geneSymbol) uc336uso.1 uc336uso.1 
ENSMUST00000341845.1 ENSMUSG00000137441 ENSMUST00000341845.1 ENSMUSG00000137441 (from geneSymbol) uc336usp.1 uc336usp.1 
ENSMUST00000341847.1 ENSMUSG00000137442 ENSMUST00000341847.1 ENSMUSG00000137442 (from geneSymbol) uc336usr.1 uc336usr.1 
ENSMUST00000341848.1 ENSMUSG00000137443 ENSMUST00000341848.1 ENSMUSG00000137443 (from geneSymbol) uc336uss.1 uc336uss.1 
ENSMUST00000341854.1 ENSMUSG00000137444 ENSMUST00000341854.1 ENSMUSG00000137444 (from geneSymbol) uc336usy.1 uc336usy.1 
ENSMUST00000341855.1 ENSMUSG00000137445 ENSMUST00000341855.1 ENSMUSG00000137445 (from geneSymbol) uc336usz.1 uc336usz.1 
ENSMUST00000341860.1 ENSMUSG00000137446 ENSMUST00000341860.1 ENSMUSG00000137446 (from geneSymbol) uc336ute.1 uc336ute.1 
ENSMUST00000341862.1 Gm26944 ENSMUST00000341862.1 Gm26944 (from geneSymbol) uc336utg.1 uc336utg.1 
ENSMUST00000341870.1 ENSMUSG00000137448 ENSMUST00000341870.1 ENSMUSG00000137448 (from geneSymbol) uc336utn.1 uc336utn.1 
ENSMUST00000341872.1 ENSMUSG00000137449 ENSMUST00000341872.1 ENSMUSG00000137449 (from geneSymbol) uc336utp.1 uc336utp.1 
ENSMUST00000341873.1 ENSMUSG00000137450 ENSMUST00000341873.1 ENSMUSG00000137450 (from geneSymbol) uc336utq.1 uc336utq.1 
ENSMUST00000341874.1 Gm34470 ENSMUST00000341874.1 Gm34470 (from geneSymbol) uc336utr.1 uc336utr.1 
ENSMUST00000341875.1 4933427I22Rik ENSMUST00000341875.1 4933427I22Rik (from geneSymbol) AK016955 uc336uts.1 uc336uts.1 
ENSMUST00000341882.1 ENSMUSG00000137451 ENSMUST00000341882.1 ENSMUSG00000137451 (from geneSymbol) uc336utz.1 uc336utz.1 
ENSMUST00000341885.1 Gm57256 ENSMUST00000341885.1 predicted gene, 32276, transcript variant 1 (from RefSeq NR_190164.1) NR_190164 uc336uuc.1 uc336uuc.1 
ENSMUST00000341898.1 ENSMUSG00000137452 ENSMUST00000341898.1 ENSMUSG00000137452 (from geneSymbol) uc336uup.1 uc336uup.1 
ENSMUST00000341899.1 ENSMUSG00000137453 ENSMUST00000341899.1 ENSMUSG00000137453 (from geneSymbol) uc336uuq.1 uc336uuq.1 
ENSMUST00000341902.1 ENSMUSG00000137454 ENSMUST00000341902.1 ENSMUSG00000137454 (from geneSymbol) uc336uut.1 uc336uut.1 
ENSMUST00000341904.1 ENSMUSG00000137455 ENSMUST00000341904.1 ENSMUSG00000137455 (from geneSymbol) uc336uuv.1 uc336uuv.1 
ENSMUST00000341905.1 ENSMUSG00000137456 ENSMUST00000341905.1 ENSMUSG00000137456 (from geneSymbol) uc336uuw.1 uc336uuw.1 
ENSMUST00000341906.1 ENSMUSG00000137457 ENSMUST00000341906.1 ENSMUSG00000137457 (from geneSymbol) uc336uux.1 uc336uux.1 
ENSMUST00000341907.1 ENSMUSG00000137458 ENSMUST00000341907.1 ENSMUSG00000137458 (from geneSymbol) uc336uuy.1 uc336uuy.1 
ENSMUST00000341908.1 Gm47855 ENSMUST00000341908.1 Gm47855 (from geneSymbol) uc336uuz.1 uc336uuz.1 
ENSMUST00000341909.1 D530017H19Rik ENSMUST00000341909.1 D530017H19Rik (from geneSymbol) uc336uva.1 uc336uva.1 
ENSMUST00000341912.1 ENSMUSG00000137459 ENSMUST00000341912.1 ENSMUSG00000137459 (from geneSymbol) uc336uvd.1 uc336uvd.1 
ENSMUST00000341913.1 ENSMUSG00000137460 ENSMUST00000341913.1 ENSMUSG00000137460 (from geneSymbol) uc336uve.1 uc336uve.1 
ENSMUST00000341915.1 ENSMUSG00000137461 ENSMUST00000341915.1 ENSMUSG00000137461 (from geneSymbol) uc336uvg.1 uc336uvg.1 
ENSMUST00000341916.1 ENSMUSG00000137462 ENSMUST00000341916.1 ENSMUSG00000137462 (from geneSymbol) uc336uvh.1 uc336uvh.1 
ENSMUST00000341921.1 ENSMUSG00000121375 ENSMUST00000341921.1 ENSMUSG00000121375 (from geneSymbol) uc336uvm.1 uc336uvm.1 
ENSMUST00000341942.1 ENSMUSG00000137463 ENSMUST00000341942.1 ENSMUSG00000137463 (from geneSymbol) uc336uwh.1 uc336uwh.1 
ENSMUST00000341943.1 ENSMUSG00000137464 ENSMUST00000341943.1 ENSMUSG00000137464 (from geneSymbol) uc336uwi.1 uc336uwi.1 
ENSMUST00000341945.1 Gm32474 ENSMUST00000341945.1 Gm32474 (from geneSymbol) uc336uwk.1 uc336uwk.1 
ENSMUST00000341956.1 ENSMUSG00000137465 ENSMUST00000341956.1 ENSMUSG00000137465 (from geneSymbol) uc336uwv.1 uc336uwv.1 
ENSMUST00000341957.1 ENSMUSG00000137466 ENSMUST00000341957.1 ENSMUSG00000137466 (from geneSymbol) uc336uww.1 uc336uww.1 
ENSMUST00000341959.1 ENSMUSG00000137467 ENSMUST00000341959.1 ENSMUSG00000137467 (from geneSymbol) uc336uwy.1 uc336uwy.1 
ENSMUST00000341961.1 ENSMUSG00000137468 ENSMUST00000341961.1 ENSMUSG00000137468 (from geneSymbol) uc336uxa.1 uc336uxa.1 
ENSMUST00000341963.1 ENSMUSG00000137470 ENSMUST00000341963.1 ENSMUSG00000137470 (from geneSymbol) uc336uxb.1 uc336uxb.1 
ENSMUST00000341964.1 ENSMUSG00000137471 ENSMUST00000341964.1 ENSMUSG00000137471 (from geneSymbol) uc336uxc.1 uc336uxc.1 
ENSMUST00000341967.1 ENSMUSG00000137472 ENSMUST00000341967.1 ENSMUSG00000137472 (from geneSymbol) uc336uxf.1 uc336uxf.1 
ENSMUST00000341968.1 Gm32479 ENSMUST00000341968.1 Gm32479 (from geneSymbol) AK030693 uc336uxg.1 uc336uxg.1 
ENSMUST00000341976.1 ENSMUSG00000137473 ENSMUST00000341976.1 ENSMUSG00000137473 (from geneSymbol) uc336uxo.1 uc336uxo.1 
ENSMUST00000341978.1 ENSMUSG00000137474 ENSMUST00000341978.1 ENSMUSG00000137474 (from geneSymbol) uc336uxq.1 uc336uxq.1 
ENSMUST00000341979.1 ENSMUSG00000137475 ENSMUST00000341979.1 ENSMUSG00000137475 (from geneSymbol) uc336uxr.1 uc336uxr.1 
ENSMUST00000341984.1 ENSMUSG00000137476 ENSMUST00000341984.1 ENSMUSG00000137476 (from geneSymbol) uc336uxw.1 uc336uxw.1 
ENSMUST00000341998.1 ENSMUSG00000137477 ENSMUST00000341998.1 ENSMUSG00000137477 (from geneSymbol) uc336uyk.1 uc336uyk.1 
ENSMUST00000342003.1 ENSMUSG00000137478 ENSMUST00000342003.1 ENSMUSG00000137478 (from geneSymbol) uc336uyp.1 uc336uyp.1 
ENSMUST00000342008.1 ENSMUSG00000137479 ENSMUST00000342008.1 ENSMUSG00000137479 (from geneSymbol) uc336uyu.1 uc336uyu.1 
ENSMUST00000342009.1 ENSMUSG00000137480 ENSMUST00000342009.1 ENSMUSG00000137480 (from geneSymbol) uc336uyv.1 uc336uyv.1 
ENSMUST00000342019.1 ENSMUSG00000137481 ENSMUST00000342019.1 ENSMUSG00000137481 (from geneSymbol) AK139839 uc336uzf.1 uc336uzf.1 
ENSMUST00000342020.1 ENSMUSG00000137482 ENSMUST00000342020.1 ENSMUSG00000137482 (from geneSymbol) uc336uzg.1 uc336uzg.1 
ENSMUST00000342022.1 ENSMUSG00000137483 ENSMUST00000342022.1 ENSMUSG00000137483 (from geneSymbol) uc336uzi.1 uc336uzi.1 
ENSMUST00000342024.1 ENSMUSG00000137484 ENSMUST00000342024.1 ENSMUSG00000137484 (from geneSymbol) uc336uzk.1 uc336uzk.1 
ENSMUST00000342025.1 ENSMUSG00000137485 ENSMUST00000342025.1 ENSMUSG00000137485 (from geneSymbol) uc336uzl.1 uc336uzl.1 
ENSMUST00000342026.1 ENSMUSG00000137486 ENSMUST00000342026.1 ENSMUSG00000137486 (from geneSymbol) uc336uzm.1 uc336uzm.1 
ENSMUST00000342027.1 A230057D06Rik ENSMUST00000342027.1 A230057D06Rik (from geneSymbol) AK078191 uc336uzn.1 uc336uzn.1 
ENSMUST00000342056.1 ENSMUSG00000137487 ENSMUST00000342056.1 ENSMUSG00000137487 (from geneSymbol) uc336vap.1 uc336vap.1 
ENSMUST00000342058.1 ENSMUSG00000137488 ENSMUST00000342058.1 ENSMUSG00000137488 (from geneSymbol) uc336var.1 uc336var.1 
ENSMUST00000342059.1 ENSMUSG00000137489 ENSMUST00000342059.1 ENSMUSG00000137489 (from geneSymbol) uc336vas.1 uc336vas.1 
ENSMUST00000342067.1 ENSMUSG00000137490 ENSMUST00000342067.1 ENSMUSG00000137490 (from geneSymbol) uc336vba.1 uc336vba.1 
ENSMUST00000342069.1 ENSMUSG00000137491 ENSMUST00000342069.1 predicted gene, 30225 (from RefSeq NR_166451.1) NR_166451 uc336vbc.1 uc336vbc.1 
ENSMUST00000342074.1 ENSMUSG00000137492 ENSMUST00000342074.1 ENSMUSG00000137492 (from geneSymbol) uc336vbh.1 uc336vbh.1 
ENSMUST00000342076.1 ENSMUSG00000137493 ENSMUST00000342076.1 ENSMUSG00000137493 (from geneSymbol) uc336vbj.1 uc336vbj.1 
ENSMUST00000342077.1 ENSMUSG00000137494 ENSMUST00000342077.1 ENSMUSG00000137494 (from geneSymbol) uc336vbk.1 uc336vbk.1 
ENSMUST00000342079.1 ENSMUSG00000137495 ENSMUST00000342079.1 ENSMUSG00000137495 (from geneSymbol) uc336vbm.1 uc336vbm.1 
ENSMUST00000342081.1 ENSMUSG00000137496 ENSMUST00000342081.1 ENSMUSG00000137496 (from geneSymbol) uc336vbo.1 uc336vbo.1 
ENSMUST00000342082.1 ENSMUSG00000137497 ENSMUST00000342082.1 ENSMUSG00000137497 (from geneSymbol) uc336vbp.1 uc336vbp.1 
ENSMUST00000342083.1 ENSMUSG00000137498 ENSMUST00000342083.1 ENSMUSG00000137498 (from geneSymbol) uc336vbq.1 uc336vbq.1 
ENSMUST00000342084.1 ENSMUSG00000137499 ENSMUST00000342084.1 ENSMUSG00000137499 (from geneSymbol) uc336vbr.1 uc336vbr.1 
ENSMUST00000342086.1 ENSMUSG00000137500 ENSMUST00000342086.1 ENSMUSG00000137500 (from geneSymbol) uc336vbt.1 uc336vbt.1 
ENSMUST00000342088.1 ENSMUSG00000137501 ENSMUST00000342088.1 ENSMUSG00000137501 (from geneSymbol) uc336vbv.1 uc336vbv.1 
ENSMUST00000342091.1 ENSMUSG00000137502 ENSMUST00000342091.1 predicted gene, 41474 (from RefSeq NR_168724.1) NR_168724 uc336vby.1 uc336vby.1 
ENSMUST00000342097.1 ENSMUSG00000137503 ENSMUST00000342097.1 ENSMUSG00000137503 (from geneSymbol) uc336vcd.1 uc336vcd.1 
ENSMUST00000342100.1 ENSMUSG00000137504 ENSMUST00000342100.1 ENSMUSG00000137504 (from geneSymbol) uc336vcg.1 uc336vcg.1 
ENSMUST00000342107.1 Gm57277 ENSMUST00000342107.1 Gm57277 (from geneSymbol) uc336vcn.1 uc336vcn.1 
ENSMUST00000342117.1 ENSMUSG00000137505 ENSMUST00000342117.1 ENSMUSG00000137505 (from geneSymbol) uc336vcx.1 uc336vcx.1 
ENSMUST00000342118.1 ENSMUSG00000137506 ENSMUST00000342118.1 ENSMUSG00000137506 (from geneSymbol) uc336vcy.1 uc336vcy.1 
ENSMUST00000342120.1 ENSMUSG00000137507 ENSMUST00000342120.1 ENSMUSG00000137507 (from geneSymbol) uc336vda.1 uc336vda.1 
ENSMUST00000342121.1 ENSMUSG00000137508 ENSMUST00000342121.1 ENSMUSG00000137508 (from geneSymbol) uc336vdb.1 uc336vdb.1 
ENSMUST00000342124.1 ENSMUSG00000137509 ENSMUST00000342124.1 ENSMUSG00000137509 (from geneSymbol) uc336vde.1 uc336vde.1 
ENSMUST00000342125.1 Gm18409 ENSMUST00000342125.1 Gm18409 (from geneSymbol) uc336vdf.1 uc336vdf.1 
ENSMUST00000342128.1 ENSMUSG00000137510 ENSMUST00000342128.1 ENSMUSG00000137510 (from geneSymbol) uc336vdi.1 uc336vdi.1 
ENSMUST00000342130.1 ENSMUSG00000137511 ENSMUST00000342130.1 ENSMUSG00000137511 (from geneSymbol) uc336vdk.1 uc336vdk.1 
ENSMUST00000342136.1 Gm35818 ENSMUST00000342136.1 Gm35818 (from geneSymbol) uc336vdq.1 uc336vdq.1 
ENSMUST00000342149.1 ENSMUSG00000137512 ENSMUST00000342149.1 ENSMUSG00000137512 (from geneSymbol) uc336ved.1 uc336ved.1 
ENSMUST00000342151.1 ENSMUSG00000137513 ENSMUST00000342151.1 ENSMUSG00000137513 (from geneSymbol) uc336vef.1 uc336vef.1 
ENSMUST00000342156.1 ENSMUSG00000137515 ENSMUST00000342156.1 ENSMUSG00000137515 (from geneSymbol) uc336veg.1 uc336veg.1 
ENSMUST00000342161.1 ENSMUSG00000137516 ENSMUST00000342161.1 ENSMUSG00000137516 (from geneSymbol) uc336vel.1 uc336vel.1 
ENSMUST00000342162.1 ENSMUSG00000137517 ENSMUST00000342162.1 ENSMUSG00000137517 (from geneSymbol) uc336vem.1 uc336vem.1 
ENSMUST00000342163.1 ENSMUSG00000137518 ENSMUST00000342163.1 ENSMUSG00000137518 (from geneSymbol) uc336ven.1 uc336ven.1 
ENSMUST00000342164.1 Gm49012 ENSMUST00000342164.1 Gm49012 (from geneSymbol) uc336veo.1 uc336veo.1 
ENSMUST00000342167.1 ENSMUSG00000137519 ENSMUST00000342167.1 ENSMUSG00000137519 (from geneSymbol) uc336ver.1 uc336ver.1 
ENSMUST00000342173.1 ENSMUSG00000137520 ENSMUST00000342173.1 ENSMUSG00000137520 (from geneSymbol) KY467469 uc336vex.1 uc336vex.1 
ENSMUST00000342176.1 ENSMUSG00000137521 ENSMUST00000342176.1 ENSMUSG00000137521 (from geneSymbol) uc336vfa.1 uc336vfa.1 
ENSMUST00000342177.1 Gm48396 ENSMUST00000342177.1 Gm48396 (from geneSymbol) uc336vfb.1 uc336vfb.1 
ENSMUST00000342178.1 ENSMUSG00000137522 ENSMUST00000342178.1 ENSMUSG00000137522 (from geneSymbol) uc336vfc.1 uc336vfc.1 
ENSMUST00000342182.1 ENSMUSG00000137524 ENSMUST00000342182.1 ENSMUSG00000137524 (from geneSymbol) AB346765 uc336vff.1 uc336vff.1 
ENSMUST00000342188.1 Foxd2os ENSMUST00000342188.1 Foxd2os (from geneSymbol) AK148100 uc336vfj.1 uc336vfj.1 
ENSMUST00000342206.1 ENSMUSG00000137526 ENSMUST00000342206.1 ENSMUSG00000137526 (from geneSymbol) uc336vgb.1 uc336vgb.1 
ENSMUST00000342208.1 ENSMUSG00000137527 ENSMUST00000342208.1 ENSMUSG00000137527 (from geneSymbol) uc336vgd.1 uc336vgd.1 
ENSMUST00000342212.1 ENSMUSG00000137528 ENSMUST00000342212.1 ENSMUSG00000137528 (from geneSymbol) uc336vgh.1 uc336vgh.1 
ENSMUST00000342213.1 ENSMUSG00000137529 ENSMUST00000342213.1 ENSMUSG00000137529 (from geneSymbol) uc336vgi.1 uc336vgi.1 
ENSMUST00000342214.1 Gm32184 ENSMUST00000342214.1 Gm32184 (from geneSymbol) uc336vgj.1 uc336vgj.1 
ENSMUST00000342231.1 4930467J12Rik ENSMUST00000342231.1 4930467J12Rik (from geneSymbol) AK015520 uc336vha.1 uc336vha.1 
ENSMUST00000342236.1 ENSMUSG00000137530 ENSMUST00000342236.1 ENSMUSG00000137530 (from geneSymbol) uc336vhf.1 uc336vhf.1 
ENSMUST00000342237.1 Gm57348 ENSMUST00000342237.1 Gm57348 (from geneSymbol) uc336vhg.1 uc336vhg.1 
ENSMUST00000342245.1 ENSMUSG00000137531 ENSMUST00000342245.1 ENSMUSG00000137531 (from geneSymbol) AK086683 uc336vho.1 uc336vho.1 
ENSMUST00000342246.1 ENSMUSG00000137532 ENSMUST00000342246.1 ENSMUSG00000137532 (from geneSymbol) uc336vhp.1 uc336vhp.1 
ENSMUST00000342249.1 ENSMUSG00000137533 ENSMUST00000342249.1 ENSMUSG00000137533 (from geneSymbol) uc336vhs.1 uc336vhs.1 
ENSMUST00000342250.1 Gm26671 ENSMUST00000342250.1 Gm26671 (from geneSymbol) AK040865 uc336vht.1 uc336vht.1 
ENSMUST00000342255.1 ENSMUSG00000137534 ENSMUST00000342255.1 ENSMUSG00000137534 (from geneSymbol) uc336vhy.1 uc336vhy.1 
ENSMUST00000342256.1 ENSMUSG00000137535 ENSMUST00000342256.1 ENSMUSG00000137535 (from geneSymbol) uc336vhz.1 uc336vhz.1 
ENSMUST00000342257.1 ENSMUSG00000137536 ENSMUST00000342257.1 ENSMUSG00000137536 (from geneSymbol) uc336via.1 uc336via.1 
ENSMUST00000342258.1 ENSMUSG00000137537 ENSMUST00000342258.1 ENSMUSG00000137537 (from geneSymbol) uc336vib.1 uc336vib.1 
ENSMUST00000342259.1 ENSMUSG00000137538 ENSMUST00000342259.1 ENSMUSG00000137538 (from geneSymbol) uc336vic.1 uc336vic.1 
ENSMUST00000342262.1 ENSMUSG00000137539 ENSMUST00000342262.1 ENSMUSG00000137539 (from geneSymbol) uc336vif.1 uc336vif.1 
ENSMUST00000342266.1 ENSMUSG00000137540 ENSMUST00000342266.1 ENSMUSG00000137540 (from geneSymbol) uc336vij.1 uc336vij.1 
ENSMUST00000342268.1 ENSMUSG00000137541 ENSMUST00000342268.1 ENSMUSG00000137541 (from geneSymbol) AK040580 uc336vil.1 uc336vil.1 
ENSMUST00000342272.1 ENSMUSG00000137542 ENSMUST00000342272.1 ENSMUSG00000137542 (from geneSymbol) uc336vip.1 uc336vip.1 
ENSMUST00000342273.1 ENSMUSG00000137543 ENSMUST00000342273.1 ENSMUSG00000137543 (from geneSymbol) uc336viq.1 uc336viq.1 
ENSMUST00000342274.1 ENSMUSG00000137544 ENSMUST00000342274.1 ENSMUSG00000137544 (from geneSymbol) uc336vir.1 uc336vir.1 
ENSMUST00000342279.1 ENSMUSG00000137545 ENSMUST00000342279.1 ENSMUSG00000137545 (from geneSymbol) uc336viw.1 uc336viw.1 
ENSMUST00000342280.1 ENSMUSG00000137546 ENSMUST00000342280.1 ENSMUSG00000137546 (from geneSymbol) uc336vix.1 uc336vix.1 
ENSMUST00000342281.1 ENSMUSG00000137547 ENSMUST00000342281.1 ENSMUSG00000137547 (from geneSymbol) uc336viy.1 uc336viy.1 
ENSMUST00000342282.1 ENSMUSG00000137548 ENSMUST00000342282.1 ENSMUSG00000137548 (from geneSymbol) uc336viz.1 uc336viz.1 
ENSMUST00000342286.1 ENSMUSG00000137549 ENSMUST00000342286.1 ENSMUSG00000137549 (from geneSymbol) uc336vjd.1 uc336vjd.1 
ENSMUST00000342293.1 1700060O08Rik ENSMUST00000342293.1 1700060O08Rik (from geneSymbol) AK006846 uc336vjk.1 uc336vjk.1 
ENSMUST00000342298.1 ENSMUSG00000137550 ENSMUST00000342298.1 ENSMUSG00000137550 (from geneSymbol) uc336vjp.1 uc336vjp.1 
ENSMUST00000342301.1 ENSMUSG00000137551 ENSMUST00000342301.1 ENSMUSG00000137551 (from geneSymbol) uc336vjs.1 uc336vjs.1 
ENSMUST00000342302.1 4933412E12Rik ENSMUST00000342302.1 4933412E12Rik (from geneSymbol) AK016788 uc336vjt.1 uc336vjt.1 
ENSMUST00000342319.1 ENSMUSG00000137552 ENSMUST00000342319.1 ENSMUSG00000137552 (from geneSymbol) uc336vkk.1 uc336vkk.1 
ENSMUST00000342333.1 Gm52113 ENSMUST00000342333.1 Gm52113 (from geneSymbol) uc336vky.1 uc336vky.1 
ENSMUST00000342350.1 ENSMUSG00000137553 ENSMUST00000342350.1 ENSMUSG00000137553 (from geneSymbol) uc336vlp.1 uc336vlp.1 
ENSMUST00000342355.1 ENSMUSG00000137554 ENSMUST00000342355.1 ENSMUSG00000137554 (from geneSymbol) uc336vlu.1 uc336vlu.1 
ENSMUST00000342359.1 ENSMUSG00000137555 ENSMUST00000342359.1 ENSMUSG00000137555 (from geneSymbol) uc336vlx.1 uc336vlx.1 
ENSMUST00000342360.1 ENSMUSG00000137556 ENSMUST00000342360.1 ENSMUSG00000137556 (from geneSymbol) uc336vly.1 uc336vly.1 
ENSMUST00000342361.1 ENSMUSG00000137557 ENSMUST00000342361.1 ENSMUSG00000137557 (from geneSymbol) uc336vlz.1 uc336vlz.1 
ENSMUST00000342362.1 ENSMUSG00000137558 ENSMUST00000342362.1 ENSMUSG00000137558 (from geneSymbol) uc336vma.1 uc336vma.1 
ENSMUST00000342364.1 ENSMUSG00000137559 ENSMUST00000342364.1 ENSMUSG00000137559 (from geneSymbol) uc336vmc.1 uc336vmc.1 
ENSMUST00000342371.1 ENSMUSG00000137560 ENSMUST00000342371.1 ENSMUSG00000137560 (from geneSymbol) uc336vmj.1 uc336vmj.1 
ENSMUST00000342391.1 ENSMUSG00000137561 ENSMUST00000342391.1 ENSMUSG00000137561 (from geneSymbol) uc336vnd.1 uc336vnd.1 
ENSMUST00000342392.1 ENSMUSG00000137562 ENSMUST00000342392.1 ENSMUSG00000137562 (from geneSymbol) uc336vne.1 uc336vne.1 
ENSMUST00000342394.1 ENSMUSG00000137563 ENSMUST00000342394.1 ENSMUSG00000137563 (from geneSymbol) uc336vng.1 uc336vng.1 
ENSMUST00000342395.1 ENSMUSG00000137564 ENSMUST00000342395.1 ENSMUSG00000137564 (from geneSymbol) uc336vnh.1 uc336vnh.1 
ENSMUST00000342398.1 1700112J05Rik ENSMUST00000342398.1 1700112J05Rik (from geneSymbol) AK018948 uc336vnk.1 uc336vnk.1 
ENSMUST00000342411.1 ENSMUSG00000137565 ENSMUST00000342411.1 ENSMUSG00000137565 (from geneSymbol) uc336vnx.1 uc336vnx.1 
ENSMUST00000342416.1 ENSMUSG00000137566 ENSMUST00000342416.1 ENSMUSG00000137566 (from geneSymbol) uc336voc.1 uc336voc.1 
ENSMUST00000342420.1 ENSMUSG00000137567 ENSMUST00000342420.1 ENSMUSG00000137567 (from geneSymbol) uc336vog.1 uc336vog.1 
ENSMUST00000342421.1 ENSMUSG00000137568 ENSMUST00000342421.1 ENSMUSG00000137568 (from geneSymbol) uc336voh.1 uc336voh.1 
ENSMUST00000342422.1 ENSMUSG00000137569 ENSMUST00000342422.1 ENSMUSG00000137569 (from geneSymbol) uc336voi.1 uc336voi.1 
ENSMUST00000342423.1 ENSMUSG00000137570 ENSMUST00000342423.1 ENSMUSG00000137570 (from geneSymbol) uc336voj.1 uc336voj.1 
ENSMUST00000342426.1 ENSMUSG00000137571 ENSMUST00000342426.1 ENSMUSG00000137571 (from geneSymbol) uc336vom.1 uc336vom.1 
ENSMUST00000342428.1 4930558G05Rik ENSMUST00000342428.1 RIKEN cDNA 4930558G05 gene (from RefSeq NR_045441.1) NR_045441 uc336voo.1 uc336voo.1 
ENSMUST00000342432.1 ENSMUSG00000137572 ENSMUST00000342432.1 ENSMUSG00000137572 (from geneSymbol) LF201593 uc336vos.1 uc336vos.1 
ENSMUST00000342433.1 ENSMUSG00000137573 ENSMUST00000342433.1 ENSMUSG00000137573 (from geneSymbol) uc336vot.1 uc336vot.1 
ENSMUST00000342434.1 ENSMUSG00000137574 ENSMUST00000342434.1 ENSMUSG00000137574 (from geneSymbol) uc336vou.1 uc336vou.1 
ENSMUST00000342435.1 ENSMUSG00000137575 ENSMUST00000342435.1 ENSMUSG00000137575 (from geneSymbol) uc336vov.1 uc336vov.1 
ENSMUST00000342437.1 1700101O22Rik ENSMUST00000342437.1 1700101O22Rik (from geneSymbol) AK007110 uc336vox.1 uc336vox.1 
ENSMUST00000342458.1 ENSMUSG00000137576 ENSMUST00000342458.1 ENSMUSG00000137576 (from geneSymbol) uc336vps.1 uc336vps.1 
ENSMUST00000342464.1 Gm34045 ENSMUST00000342464.1 Gm34045 (from geneSymbol) AK136051 uc336vpy.1 uc336vpy.1 
ENSMUST00000342473.1 ENSMUSG00000137577 ENSMUST00000342473.1 ENSMUSG00000137577 (from geneSymbol) uc336vqh.1 uc336vqh.1 
ENSMUST00000342477.1 ENSMUSG00000137578 ENSMUST00000342477.1 ENSMUSG00000137578 (from geneSymbol) uc336vql.1 uc336vql.1 
ENSMUST00000342479.1 ENSMUSG00000137579 ENSMUST00000342479.1 ENSMUSG00000137579 (from geneSymbol) uc336vqn.1 uc336vqn.1 
ENSMUST00000342483.1 1700123M08Rik ENSMUST00000342483.1 1700123M08Rik (from geneSymbol) AK005538 uc336vqr.1 uc336vqr.1 
ENSMUST00000342531.1 ENSMUSG00000137580 ENSMUST00000342531.1 ENSMUSG00000137580 (from geneSymbol) uc336vsn.1 uc336vsn.1 
ENSMUST00000342532.1 ENSMUSG00000137581 ENSMUST00000342532.1 ENSMUSG00000137581 (from geneSymbol) uc336vso.1 uc336vso.1 
ENSMUST00000342535.1 Gm32284 ENSMUST00000342535.1 Gm32284 (from geneSymbol) uc336vsr.1 uc336vsr.1 
ENSMUST00000342544.1 ENSMUSG00000137582 ENSMUST00000342544.1 ENSMUSG00000137582 (from geneSymbol) uc336vta.1 uc336vta.1 
ENSMUST00000342545.1 ENSMUSG00000137583 ENSMUST00000342545.1 ENSMUSG00000137583 (from geneSymbol) uc336vtb.1 uc336vtb.1 
ENSMUST00000342546.1 Gm14546 ENSMUST00000342546.1 Gm14546 (from geneSymbol) AK139340 uc336vtc.1 uc336vtc.1 
ENSMUST00000342557.1 Gm57265 ENSMUST00000342557.1 Gm57265 (from geneSymbol) uc336vtn.1 uc336vtn.1 
ENSMUST00000342558.1 ENSMUSG00000137584 ENSMUST00000342558.1 ENSMUSG00000137584 (from geneSymbol) uc336vto.1 uc336vto.1 
ENSMUST00000342559.1 ENSMUSG00000137585 ENSMUST00000342559.1 ENSMUSG00000137585 (from geneSymbol) uc336vtp.1 uc336vtp.1 
ENSMUST00000342560.1 ENSMUSG00000137586 ENSMUST00000342560.1 ENSMUSG00000137586 (from geneSymbol) uc336vtq.1 uc336vtq.1 
ENSMUST00000342562.1 ENSMUSG00000137587 ENSMUST00000342562.1 ENSMUSG00000137587 (from geneSymbol) uc336vts.1 uc336vts.1 
ENSMUST00000342564.1 ENSMUSG00000137588 ENSMUST00000342564.1 ENSMUSG00000137588 (from geneSymbol) uc336vtu.1 uc336vtu.1 
ENSMUST00000342567.1 ENSMUSG00000137589 ENSMUST00000342567.1 ENSMUSG00000137589 (from geneSymbol) uc336vtx.1 uc336vtx.1 
ENSMUST00000342574.1 ENSMUSG00000137590 ENSMUST00000342574.1 ENSMUSG00000137590 (from geneSymbol) uc336vue.1 uc336vue.1 
ENSMUST00000342575.1 ENSMUSG00000137591 ENSMUST00000342575.1 ENSMUSG00000137591 (from geneSymbol) uc336vuf.1 uc336vuf.1 
ENSMUST00000342577.1 ENSMUSG00000137592 ENSMUST00000342577.1 ENSMUSG00000137592 (from geneSymbol) uc336vuh.1 uc336vuh.1 
ENSMUST00000342578.1 ENSMUSG00000137593 ENSMUST00000342578.1 ENSMUSG00000137593 (from geneSymbol) uc336vui.1 uc336vui.1 
ENSMUST00000342579.1 ENSMUSG00000137594 ENSMUST00000342579.1 ENSMUSG00000137594 (from geneSymbol) uc336vuj.1 uc336vuj.1 
ENSMUST00000342580.1 ENSMUSG00000137595 ENSMUST00000342580.1 ENSMUSG00000137595 (from geneSymbol) uc336vuk.1 uc336vuk.1 
ENSMUST00000342583.1 ENSMUSG00000137596 ENSMUST00000342583.1 ENSMUSG00000137596 (from geneSymbol) uc336vun.1 uc336vun.1 
ENSMUST00000342587.1 ENSMUSG00000137597 ENSMUST00000342587.1 ENSMUSG00000137597 (from geneSymbol) uc336vur.1 uc336vur.1 
ENSMUST00000342588.1 ENSMUSG00000137598 ENSMUST00000342588.1 ENSMUSG00000137598 (from geneSymbol) uc336vus.1 uc336vus.1 
ENSMUST00000342589.1 ENSMUSG00000137599 ENSMUST00000342589.1 ENSMUSG00000137599 (from geneSymbol) uc336vut.1 uc336vut.1 
ENSMUST00000342590.1 ENSMUSG00000137600 ENSMUST00000342590.1 ENSMUSG00000137600 (from geneSymbol) uc336vuu.1 uc336vuu.1 
ENSMUST00000342591.1 ENSMUSG00000137601 ENSMUST00000342591.1 ENSMUSG00000137601 (from geneSymbol) uc336vuv.1 uc336vuv.1 
ENSMUST00000342594.1 ENSMUSG00000137602 ENSMUST00000342594.1 ENSMUSG00000137602 (from geneSymbol) uc336vuy.1 uc336vuy.1 
ENSMUST00000342595.1 ENSMUSG00000137603 ENSMUST00000342595.1 ENSMUSG00000137603 (from geneSymbol) uc336vuz.1 uc336vuz.1 
ENSMUST00000342601.1 ENSMUSG00000137604 ENSMUST00000342601.1 ENSMUSG00000137604 (from geneSymbol) uc336vvf.1 uc336vvf.1 
ENSMUST00000342604.1 ENSMUSG00000137605 ENSMUST00000342604.1 ENSMUSG00000137605 (from geneSymbol) uc336vvi.1 uc336vvi.1 
ENSMUST00000342605.1 Gm45564 ENSMUST00000342605.1 Gm45564 (from geneSymbol) uc336vvj.1 uc336vvj.1 
ENSMUST00000342613.1 ENSMUSG00000137606 ENSMUST00000342613.1 ENSMUSG00000137606 (from geneSymbol) uc336vvr.1 uc336vvr.1 
ENSMUST00000342614.1 ENSMUSG00000137607 ENSMUST00000342614.1 ENSMUSG00000137607 (from geneSymbol) uc336vvs.1 uc336vvs.1 
ENSMUST00000342615.1 ENSMUSG00000137608 ENSMUST00000342615.1 ENSMUSG00000137608 (from geneSymbol) uc336vvt.1 uc336vvt.1 
ENSMUST00000342617.1 ENSMUSG00000137609 ENSMUST00000342617.1 ENSMUSG00000137609 (from geneSymbol) uc336vvv.1 uc336vvv.1 
ENSMUST00000342623.1 ENSMUSG00000137610 ENSMUST00000342623.1 ENSMUSG00000137610 (from geneSymbol) uc336vwb.1 uc336vwb.1 
ENSMUST00000342624.1 ENSMUSG00000137611 ENSMUST00000342624.1 ENSMUSG00000137611 (from geneSymbol) uc336vwc.1 uc336vwc.1 
ENSMUST00000342625.1 ENSMUSG00000137612 ENSMUST00000342625.1 ENSMUSG00000137612 (from geneSymbol) uc336vwd.1 uc336vwd.1 
ENSMUST00000342626.1 ENSMUSG00000137613 ENSMUST00000342626.1 ENSMUSG00000137613 (from geneSymbol) uc336vwe.1 uc336vwe.1 
ENSMUST00000342627.1 ENSMUSG00000137614 ENSMUST00000342627.1 ENSMUSG00000137614 (from geneSymbol) uc336vwf.1 uc336vwf.1 
ENSMUST00000342628.1 ENSMUSG00000137615 ENSMUST00000342628.1 ENSMUSG00000137615 (from geneSymbol) uc336vwg.1 uc336vwg.1 
ENSMUST00000342630.1 ENSMUSG00000137616 ENSMUST00000342630.1 ENSMUSG00000137616 (from geneSymbol) uc336vwi.1 uc336vwi.1 
ENSMUST00000342632.1 ENSMUSG00000137617 ENSMUST00000342632.1 ENSMUSG00000137617 (from geneSymbol) uc336vwk.1 uc336vwk.1 
ENSMUST00000342634.1 ENSMUSG00000137618 ENSMUST00000342634.1 ENSMUSG00000137618 (from geneSymbol) uc336vwm.1 uc336vwm.1 
ENSMUST00000342638.1 ENSMUSG00000137619 ENSMUST00000342638.1 ENSMUSG00000137619 (from geneSymbol) uc336vwq.1 uc336vwq.1 
ENSMUST00000342652.1 ENSMUSG00000137620 ENSMUST00000342652.1 ENSMUSG00000137620 (from geneSymbol) uc336vxe.1 uc336vxe.1 
ENSMUST00000342653.1 ENSMUSG00000137621 ENSMUST00000342653.1 ENSMUSG00000137621 (from geneSymbol) uc336vxf.1 uc336vxf.1 
ENSMUST00000342656.1 Gm2895 ENSMUST00000342656.1 Gm2895 (from geneSymbol) AK132376 uc336vxi.1 uc336vxi.1 
ENSMUST00000342683.1 ENSMUSG00000137622 ENSMUST00000342683.1 ENSMUSG00000137622 (from geneSymbol) uc336vyj.1 uc336vyj.1 
ENSMUST00000342686.1 ENSMUSG00000137623 ENSMUST00000342686.1 ENSMUSG00000137623 (from geneSymbol) uc336vym.1 uc336vym.1 
ENSMUST00000342687.1 ENSMUSG00000137624 ENSMUST00000342687.1 ENSMUSG00000137624 (from geneSymbol) DQ720685 uc336vyn.1 uc336vyn.1 
ENSMUST00000342688.1 Ptgs2os ENSMUST00000342688.1 Ptgs2os (from geneSymbol) AK078714 uc336vyo.1 uc336vyo.1 
ENSMUST00000342694.1 ENSMUSG00000137625 ENSMUST00000342694.1 ENSMUSG00000137625 (from geneSymbol) uc336vyu.1 uc336vyu.1 
ENSMUST00000342697.1 ENSMUSG00000137626 ENSMUST00000342697.1 ENSMUSG00000137626 (from geneSymbol) uc336vyx.1 uc336vyx.1 
ENSMUST00000342699.1 Gm11840 ENSMUST00000342699.1 Gm11840 (from geneSymbol) AK076817 uc336vyz.1 uc336vyz.1 
ENSMUST00000342721.1 ENSMUSG00000137627 ENSMUST00000342721.1 ENSMUSG00000137627 (from geneSymbol) uc336vzv.1 uc336vzv.1 
ENSMUST00000342722.1 ENSMUSG00000137628 ENSMUST00000342722.1 ENSMUSG00000137628 (from geneSymbol) uc336vzw.1 uc336vzw.1 
ENSMUST00000342723.1 ENSMUSG00000137629 ENSMUST00000342723.1 ENSMUSG00000137629 (from geneSymbol) uc336vzx.1 uc336vzx.1 
ENSMUST00000342724.1 ENSMUSG00000137630 ENSMUST00000342724.1 ENSMUSG00000137630 (from geneSymbol) uc336vzy.1 uc336vzy.1 
ENSMUST00000342725.1 ENSMUSG00000137631 ENSMUST00000342725.1 ENSMUSG00000137631 (from geneSymbol) uc336vzz.1 uc336vzz.1 
ENSMUST00000342726.1 ENSMUSG00000137632 ENSMUST00000342726.1 ENSMUSG00000137632 (from geneSymbol) uc336waa.1 uc336waa.1 
ENSMUST00000342727.1 ENSMUSG00000137633 ENSMUST00000342727.1 ENSMUSG00000137633 (from geneSymbol) uc336wab.1 uc336wab.1 
ENSMUST00000342730.1 ENSMUSG00000137634 ENSMUST00000342730.1 ENSMUSG00000137634 (from geneSymbol) uc336wae.1 uc336wae.1 
ENSMUST00000342734.1 ENSMUSG00000137635 ENSMUST00000342734.1 ENSMUSG00000137635 (from geneSymbol) uc336wai.1 uc336wai.1 
ENSMUST00000342735.1 ENSMUSG00000137636 ENSMUST00000342735.1 ENSMUSG00000137636 (from geneSymbol) uc336waj.1 uc336waj.1 
ENSMUST00000342736.1 ENSMUSG00000137637 ENSMUST00000342736.1 ENSMUSG00000137637 (from geneSymbol) uc336wak.1 uc336wak.1 
ENSMUST00000342740.1 ENSMUSG00000137638 ENSMUST00000342740.1 ENSMUSG00000137638 (from geneSymbol) uc336wao.1 uc336wao.1 
ENSMUST00000342741.1 ENSMUSG00000137639 ENSMUST00000342741.1 ENSMUSG00000137639 (from geneSymbol) uc336wap.1 uc336wap.1 
ENSMUST00000342742.1 ENSMUSG00000137640 ENSMUST00000342742.1 ENSMUSG00000137640 (from geneSymbol) uc336waq.1 uc336waq.1 
ENSMUST00000342744.1 Gm37306 ENSMUST00000342744.1 Gm37306 (from geneSymbol) AK156859 uc336was.1 uc336was.1 
ENSMUST00000342745.1 ENSMUSG00000137641 ENSMUST00000342745.1 ENSMUSG00000137641 (from geneSymbol) uc336wat.1 uc336wat.1 
ENSMUST00000342748.1 ENSMUSG00000137642 ENSMUST00000342748.1 ENSMUSG00000137642 (from geneSymbol) uc336waw.1 uc336waw.1 
ENSMUST00000342749.1 ENSMUSG00000137643 ENSMUST00000342749.1 ENSMUSG00000137643 (from geneSymbol) uc336wax.1 uc336wax.1 
ENSMUST00000342751.1 ENSMUSG00000137644 ENSMUST00000342751.1 ENSMUSG00000137644 (from geneSymbol) uc336waz.1 uc336waz.1 
ENSMUST00000342752.1 ENSMUSG00000137645 ENSMUST00000342752.1 ENSMUSG00000137645 (from geneSymbol) uc336wba.1 uc336wba.1 
ENSMUST00000342770.1 ENSMUSG00000137646 ENSMUST00000342770.1 ENSMUSG00000137646 (from geneSymbol) uc336wbs.1 uc336wbs.1 
ENSMUST00000342777.1 ENSMUSG00000137648 ENSMUST00000342777.1 ENSMUSG00000137648 (from geneSymbol) uc336wby.1 uc336wby.1 
ENSMUST00000342778.1 ENSMUSG00000137649 ENSMUST00000342778.1 ENSMUSG00000137649 (from geneSymbol) AK019727 uc336wbz.1 uc336wbz.1 
ENSMUST00000342792.1 ENSMUSG00000137650 ENSMUST00000342792.1 ENSMUSG00000137650 (from geneSymbol) uc336wcn.1 uc336wcn.1 
ENSMUST00000342793.1 ENSMUSG00000137651 ENSMUST00000342793.1 ENSMUSG00000137651 (from geneSymbol) AK015222 uc336wco.1 uc336wco.1 
ENSMUST00000342794.1 ENSMUSG00000137652 ENSMUST00000342794.1 ENSMUSG00000137652 (from geneSymbol) uc336wcp.1 uc336wcp.1 
ENSMUST00000342800.1 ENSMUSG00000137653 ENSMUST00000342800.1 ENSMUSG00000137653 (from geneSymbol) uc336wcv.1 uc336wcv.1 
ENSMUST00000342814.1 Gm57370 ENSMUST00000342814.1 Gm57370 (from geneSymbol) uc336wdj.1 uc336wdj.1 
ENSMUST00000342816.1 ENSMUSG00000137654 ENSMUST00000342816.1 ENSMUSG00000137654 (from geneSymbol) uc336wdl.1 uc336wdl.1 
ENSMUST00000342817.1 ENSMUSG00000137655 ENSMUST00000342817.1 ENSMUSG00000137655 (from geneSymbol) uc336wdm.1 uc336wdm.1 
ENSMUST00000342823.1 ENSMUSG00000137656 ENSMUST00000342823.1 ENSMUSG00000137656 (from geneSymbol) uc336wds.1 uc336wds.1 
ENSMUST00000342828.1 Gm31063 ENSMUST00000342828.1 Gm31063 (from geneSymbol) AK081945 uc336wdx.1 uc336wdx.1 
ENSMUST00000342837.1 ENSMUSG00000137657 ENSMUST00000342837.1 ENSMUSG00000137657 (from geneSymbol) uc336weg.1 uc336weg.1 
ENSMUST00000342844.1 Gm8749 ENSMUST00000342844.1 predicted gene 8749 (from RefSeq NR_165623.1) NR_165623 uc336wen.1 uc336wen.1 
ENSMUST00000342846.1 ENSMUSG00000137659 ENSMUST00000342846.1 ENSMUSG00000137659 (from geneSymbol) uc336wep.1 uc336wep.1 
ENSMUST00000342847.1 ENSMUSG00000137660 ENSMUST00000342847.1 ENSMUSG00000137660 (from geneSymbol) uc336weq.1 uc336weq.1 
ENSMUST00000342850.1 Gm32202 ENSMUST00000342850.1 Gm32202 (from geneSymbol) uc336wet.1 uc336wet.1 
ENSMUST00000342851.1 ENSMUSG00000137661 ENSMUST00000342851.1 ENSMUSG00000137661 (from geneSymbol) uc336weu.1 uc336weu.1 
ENSMUST00000342853.1 ENSMUSG00000137662 ENSMUST00000342853.1 ENSMUSG00000137662 (from geneSymbol) uc336wew.1 uc336wew.1 
ENSMUST00000342855.1 ENSMUSG00000137663 ENSMUST00000342855.1 ENSMUSG00000137663 (from geneSymbol) uc336wey.1 uc336wey.1 
ENSMUST00000342856.1 Gm49618 ENSMUST00000342856.1 Gm49618 (from geneSymbol) uc336wez.1 uc336wez.1 
ENSMUST00000342871.1 ENSMUSG00000137664 ENSMUST00000342871.1 ENSMUSG00000137664 (from geneSymbol) uc336wfn.1 uc336wfn.1 
ENSMUST00000342873.1 ENSMUSG00000137665 ENSMUST00000342873.1 ENSMUSG00000137665 (from geneSymbol) uc336wfp.1 uc336wfp.1 
ENSMUST00000342876.1 ENSMUSG00000137666 ENSMUST00000342876.1 ENSMUSG00000137666 (from geneSymbol) uc336wfs.1 uc336wfs.1 
ENSMUST00000342877.1 ENSMUSG00000137667 ENSMUST00000342877.1 ENSMUSG00000137667 (from geneSymbol) uc336wft.1 uc336wft.1 
ENSMUST00000342878.1 ENSMUSG00000137668 ENSMUST00000342878.1 ENSMUSG00000137668 (from geneSymbol) uc336wfu.1 uc336wfu.1 
ENSMUST00000342879.1 ENSMUSG00000137669 ENSMUST00000342879.1 ENSMUSG00000137669 (from geneSymbol) uc336wfv.1 uc336wfv.1 
ENSMUST00000342880.1 ENSMUSG00000137670 ENSMUST00000342880.1 ENSMUSG00000137670 (from geneSymbol) uc336wfw.1 uc336wfw.1 
ENSMUST00000342882.1 Gm28459 ENSMUST00000342882.1 Gm28459 (from geneSymbol) uc336wfy.1 uc336wfy.1 
ENSMUST00000342883.1 ENSMUSG00000137672 ENSMUST00000342883.1 ENSMUSG00000137672 (from geneSymbol) uc336wfz.1 uc336wfz.1 
ENSMUST00000342885.1 ENSMUSG00000137673 ENSMUST00000342885.1 ENSMUSG00000137673 (from geneSymbol) uc336wgb.1 uc336wgb.1 
ENSMUST00000342886.1 ENSMUSG00000137674 ENSMUST00000342886.1 ENSMUSG00000137674 (from geneSymbol) uc336wgc.1 uc336wgc.1 
ENSMUST00000342894.1 ENSMUSG00000137675 ENSMUST00000342894.1 ENSMUSG00000137675 (from geneSymbol) uc336wgk.1 uc336wgk.1 
ENSMUST00000342895.1 ENSMUSG00000137676 ENSMUST00000342895.1 ENSMUSG00000137676 (from geneSymbol) uc336wgl.1 uc336wgl.1 
ENSMUST00000342898.1 Gm11716 ENSMUST00000342898.1 predicted gene 11716, transcript variant 2 (from RefSeq NR_166849.1) NR_166849 uc336wgo.1 uc336wgo.1 
ENSMUST00000342909.1 ENSMUSG00000137677 ENSMUST00000342909.1 ENSMUSG00000137677 (from geneSymbol) uc336wgz.1 uc336wgz.1 
ENSMUST00000342911.1 ENSMUSG00000137678 ENSMUST00000342911.1 ENSMUSG00000137678 (from geneSymbol) uc336whb.1 uc336whb.1 
ENSMUST00000342913.1 Gm26801 ENSMUST00000342913.1 Gm26801 (from geneSymbol) AK048867 uc336whc.1 uc336whc.1 
ENSMUST00000342923.1 ENSMUSG00000137679 ENSMUST00000342923.1 ENSMUSG00000137679 (from geneSymbol) uc336whm.1 uc336whm.1 
ENSMUST00000342925.1 ENSMUSG00000137680 ENSMUST00000342925.1 ENSMUSG00000137680 (from geneSymbol) uc336who.1 uc336who.1 
ENSMUST00000342929.1 Gm11184 ENSMUST00000342929.1 Gm11184 (from geneSymbol) uc336whs.1 uc336whs.1 
ENSMUST00000342937.1 Gm12974 ENSMUST00000342937.1 Gm12974 (from geneSymbol) KY468022 uc336wia.1 uc336wia.1 
ENSMUST00000342964.1 ENSMUSG00000137681 ENSMUST00000342964.1 ENSMUSG00000137681 (from geneSymbol) uc336wjb.1 uc336wjb.1 
ENSMUST00000342967.1 ENSMUSG00000137682 ENSMUST00000342967.1 ENSMUSG00000137682 (from geneSymbol) uc336wje.1 uc336wje.1 
ENSMUST00000342968.1 ENSMUSG00000137683 ENSMUST00000342968.1 ENSMUSG00000137683 (from geneSymbol) uc336wjf.1 uc336wjf.1 
ENSMUST00000342971.1 Gm57436 ENSMUST00000342971.1 predicted gene, 36691 (from RefSeq NR_168322.1) NR_168322 uc336wji.1 uc336wji.1 
ENSMUST00000342982.1 ENSMUSG00000137684 ENSMUST00000342982.1 ENSMUSG00000137684 (from geneSymbol) uc336wjt.1 uc336wjt.1 
ENSMUST00000342985.1 ENSMUSG00000137685 ENSMUST00000342985.1 ENSMUSG00000137685 (from geneSymbol) uc336wjw.1 uc336wjw.1 
ENSMUST00000342986.1 ENSMUSG00000137686 ENSMUST00000342986.1 ENSMUSG00000137686 (from geneSymbol) uc336wjx.1 uc336wjx.1 
ENSMUST00000342987.1 ENSMUSG00000137687 ENSMUST00000342987.1 ENSMUSG00000137687 (from geneSymbol) uc336wjy.1 uc336wjy.1 
ENSMUST00000342992.1 ENSMUSG00000137688 ENSMUST00000342992.1 ENSMUSG00000137688 (from geneSymbol) uc336wkd.1 uc336wkd.1 
ENSMUST00000342993.1 ENSMUSG00000137689 ENSMUST00000342993.1 ENSMUSG00000137689 (from geneSymbol) uc336wke.1 uc336wke.1 
ENSMUST00000342994.1 ENSMUSG00000137690 ENSMUST00000342994.1 ENSMUSG00000137690 (from geneSymbol) uc336wkf.1 uc336wkf.1 
ENSMUST00000342997.1 Gm57046 ENSMUST00000342997.1 Gm57046 (from geneSymbol) uc336wki.1 uc336wki.1 
ENSMUST00000343004.1 ENSMUSG00000137691 ENSMUST00000343004.1 ENSMUSG00000137691 (from geneSymbol) uc336wkp.1 uc336wkp.1 
ENSMUST00000343005.1 ENSMUSG00000137692 ENSMUST00000343005.1 ENSMUSG00000137692 (from geneSymbol) uc336wkq.1 uc336wkq.1 
ENSMUST00000343008.1 ENSMUSG00000137693 ENSMUST00000343008.1 ENSMUSG00000137693 (from geneSymbol) uc336wkt.1 uc336wkt.1 
ENSMUST00000343009.1 ENSMUSG00000137694 ENSMUST00000343009.1 ENSMUSG00000137694 (from geneSymbol) uc336wku.1 uc336wku.1 
ENSMUST00000343012.1 ENSMUSG00000137695 ENSMUST00000343012.1 ENSMUSG00000137695 (from geneSymbol) uc336wkx.1 uc336wkx.1 
ENSMUST00000343013.1 ENSMUSG00000137696 ENSMUST00000343013.1 ENSMUSG00000137696 (from geneSymbol) uc336wky.1 uc336wky.1 
ENSMUST00000343014.1 4930471E15Rik ENSMUST00000343014.1 4930471E15Rik (from geneSymbol) AK015548 uc336wkz.1 uc336wkz.1 
ENSMUST00000343015.1 ENSMUSG00000137697 ENSMUST00000343015.1 ENSMUSG00000137697 (from geneSymbol) uc336wla.1 uc336wla.1 
ENSMUST00000343018.1 ENSMUSG00000137698 ENSMUST00000343018.1 ENSMUSG00000137698 (from geneSymbol) uc336wld.1 uc336wld.1 
ENSMUST00000343023.1 Tnfsf13os ENSMUST00000343023.1 Tnfsf13os (from geneSymbol) AK008218 uc336wli.1 uc336wli.1 
ENSMUST00000343031.1 4930455C13Rik ENSMUST00000343031.1 4930455C13Rik (from geneSymbol) AK015459 uc336wlq.1 uc336wlq.1 
ENSMUST00000343045.1 ENSMUSG00000137699 ENSMUST00000343045.1 ENSMUSG00000137699 (from geneSymbol) uc336wme.1 uc336wme.1 
ENSMUST00000343046.1 ENSMUSG00000137700 ENSMUST00000343046.1 ENSMUSG00000137700 (from geneSymbol) uc336wmf.1 uc336wmf.1 
ENSMUST00000343047.1 ENSMUSG00000137701 ENSMUST00000343047.1 ENSMUSG00000137701 (from geneSymbol) uc336wmg.1 uc336wmg.1 
ENSMUST00000343051.1 ENSMUSG00000137702 ENSMUST00000343051.1 ENSMUSG00000137702 (from geneSymbol) uc336wmk.1 uc336wmk.1 
ENSMUST00000343055.1 ENSMUSG00000137703 ENSMUST00000343055.1 ENSMUSG00000137703 (from geneSymbol) AK006494 uc336wmo.1 uc336wmo.1 
ENSMUST00000343056.1 ENSMUSG00000137704 ENSMUST00000343056.1 ENSMUSG00000137704 (from geneSymbol) uc336wmp.1 uc336wmp.1 
ENSMUST00000343057.1 Gm3279 ENSMUST00000343057.1 Gm3279 (from geneSymbol) AK038589 uc336wmq.1 uc336wmq.1 
ENSMUST00000343062.1 ENSMUSG00000137705 ENSMUST00000343062.1 ENSMUSG00000137705 (from geneSymbol) uc336wmv.1 uc336wmv.1 
ENSMUST00000343081.1 ENSMUSG00000137706 ENSMUST00000343081.1 ENSMUSG00000137706 (from geneSymbol) uc336wno.1 uc336wno.1 
ENSMUST00000343100.1 ENSMUSG00000137707 ENSMUST00000343100.1 ENSMUSG00000137707 (from geneSymbol) uc336woh.1 uc336woh.1 
ENSMUST00000343103.1 ENSMUSG00000137708 ENSMUST00000343103.1 ENSMUSG00000137708 (from geneSymbol) uc336wok.1 uc336wok.1 
ENSMUST00000343109.1 ENSMUSG00000137710 ENSMUST00000343109.1 ENSMUSG00000137710 (from geneSymbol) DQ703913 uc336wop.1 uc336wop.1 
ENSMUST00000343110.1 ENSMUSG00000137711 ENSMUST00000343110.1 ENSMUSG00000137711 (from geneSymbol) uc336woq.1 uc336woq.1 
ENSMUST00000343111.1 ENSMUSG00000137712 ENSMUST00000343111.1 ENSMUSG00000137712 (from geneSymbol) uc336wor.1 uc336wor.1 
ENSMUST00000343112.1 ENSMUSG00000137713 ENSMUST00000343112.1 ENSMUSG00000137713 (from geneSymbol) uc336wos.1 uc336wos.1 
ENSMUST00000343115.1 ENSMUSG00000137714 ENSMUST00000343115.1 ENSMUSG00000137714 (from geneSymbol) uc336wov.1 uc336wov.1 
ENSMUST00000343120.1 ENSMUSG00000137715 ENSMUST00000343120.1 ENSMUSG00000137715 (from geneSymbol) uc336wpa.1 uc336wpa.1 
ENSMUST00000343123.1 ENSMUSG00000137716 ENSMUST00000343123.1 ENSMUSG00000137716 (from geneSymbol) FJ541075 uc336wpd.1 uc336wpd.1 
ENSMUST00000343133.1 Gm29856 ENSMUST00000343133.1 Gm29856 (from geneSymbol) AK082514 uc336wpm.1 uc336wpm.1 
ENSMUST00000343143.1 ENSMUSG00000137718 ENSMUST00000343143.1 ENSMUSG00000137718 (from geneSymbol) uc336wpw.1 uc336wpw.1 
ENSMUST00000343155.1 Gm57340 ENSMUST00000343155.1 Gm57340 (from geneSymbol) uc336wqi.1 uc336wqi.1 
ENSMUST00000343158.1 ENSMUSG00000137719 ENSMUST00000343158.1 ENSMUSG00000137719 (from geneSymbol) uc336wql.1 uc336wql.1 
ENSMUST00000343159.1 ENSMUSG00000137720 ENSMUST00000343159.1 ENSMUSG00000137720 (from geneSymbol) uc336wqm.1 uc336wqm.1 
ENSMUST00000343168.1 ENSMUSG00000137721 ENSMUST00000343168.1 ENSMUSG00000137721 (from geneSymbol) uc336wqv.1 uc336wqv.1 
ENSMUST00000343169.1 ENSMUSG00000137722 ENSMUST00000343169.1 ENSMUSG00000137722 (from geneSymbol) MK071710 uc336wqw.1 uc336wqw.1 
ENSMUST00000343170.1 ENSMUSG00000137723 ENSMUST00000343170.1 ENSMUSG00000137723 (from geneSymbol) uc336wqx.1 uc336wqx.1 
ENSMUST00000343180.1 ENSMUSG00000137724 ENSMUST00000343180.1 ENSMUSG00000137724 (from geneSymbol) uc336wrh.1 uc336wrh.1 
ENSMUST00000343186.1 ENSMUSG00000137725 ENSMUST00000343186.1 ENSMUSG00000137725 (from geneSymbol) uc336wrn.1 uc336wrn.1 
ENSMUST00000343196.1 ENSMUSG00000137726 ENSMUST00000343196.1 ENSMUSG00000137726 (from geneSymbol) uc336wrx.1 uc336wrx.1 
ENSMUST00000343197.1 ENSMUSG00000137727 ENSMUST00000343197.1 ENSMUSG00000137727 (from geneSymbol) uc336wry.1 uc336wry.1 
ENSMUST00000343198.1 ENSMUSG00000137728 ENSMUST00000343198.1 ENSMUSG00000137728 (from geneSymbol) uc336wrz.1 uc336wrz.1 
ENSMUST00000343226.1 ENSMUSG00000137729 ENSMUST00000343226.1 ENSMUSG00000137729 (from geneSymbol) uc336wtb.1 uc336wtb.1 
ENSMUST00000343229.1 Gm20482 ENSMUST00000343229.1 Gm20482 (from geneSymbol) AK045648 uc336wte.1 uc336wte.1 
ENSMUST00000343230.1 ENSMUSG00000137730 ENSMUST00000343230.1 ENSMUSG00000137730 (from geneSymbol) uc336wtf.1 uc336wtf.1 
ENSMUST00000343233.1 ENSMUSG00000137731 ENSMUST00000343233.1 ENSMUSG00000137731 (from geneSymbol) uc336wti.1 uc336wti.1 
ENSMUST00000343234.1 ENSMUSG00000137732 ENSMUST00000343234.1 ENSMUSG00000137732 (from geneSymbol) uc336wtj.1 uc336wtj.1 
ENSMUST00000343237.1 ENSMUSG00000137733 ENSMUST00000343237.1 ENSMUSG00000137733 (from geneSymbol) uc336wtm.1 uc336wtm.1 
ENSMUST00000343240.1 ENSMUSG00000137734 ENSMUST00000343240.1 ENSMUSG00000137734 (from geneSymbol) uc336wtp.1 uc336wtp.1 
ENSMUST00000343241.1 ENSMUSG00000137735 ENSMUST00000343241.1 ENSMUSG00000137735 (from geneSymbol) uc336wtq.1 uc336wtq.1 
ENSMUST00000343243.1 ENSMUSG00000137736 ENSMUST00000343243.1 ENSMUSG00000137736 (from geneSymbol) uc336wts.1 uc336wts.1 
ENSMUST00000343244.1 Gm11351 ENSMUST00000343244.1 Gm11351 (from geneSymbol) AK132076 uc336wtt.1 uc336wtt.1 
ENSMUST00000343247.1 ENSMUSG00000137737 ENSMUST00000343247.1 ENSMUSG00000137737 (from geneSymbol) uc336wtw.1 uc336wtw.1 
ENSMUST00000343248.1 ENSMUSG00000137738 ENSMUST00000343248.1 ENSMUSG00000137738 (from geneSymbol) uc336wtx.1 uc336wtx.1 
ENSMUST00000343253.1 ENSMUSG00000137739 ENSMUST00000343253.1 ENSMUSG00000137739 (from geneSymbol) uc336wuc.1 uc336wuc.1 
ENSMUST00000343254.1 ENSMUSG00000137740 ENSMUST00000343254.1 ENSMUSG00000137740 (from geneSymbol) uc336wud.1 uc336wud.1 
ENSMUST00000343255.1 ENSMUSG00000137741 ENSMUST00000343255.1 ENSMUSG00000137741 (from geneSymbol) uc336wue.1 uc336wue.1 
ENSMUST00000343262.1 2810449D17Rik ENSMUST00000343262.1 RIKEN cDNA 2810449D17 gene (from RefSeq NR_166828.2) NR_166828 uc336wul.1 uc336wul.1 
ENSMUST00000343266.1 ENSMUSG00000137742 ENSMUST00000343266.1 ENSMUSG00000137742 (from geneSymbol) uc336wup.1 uc336wup.1 
ENSMUST00000343267.1 ENSMUSG00000137743 ENSMUST00000343267.1 ENSMUSG00000137743 (from geneSymbol) uc336wuq.1 uc336wuq.1 
ENSMUST00000343268.1 ENSMUSG00000137744 ENSMUST00000343268.1 ENSMUSG00000137744 (from geneSymbol) uc336wur.1 uc336wur.1 
ENSMUST00000343291.1 Gm15473 ENSMUST00000343291.1 Gm15473 (from geneSymbol) uc336wvo.1 uc336wvo.1 
ENSMUST00000343301.1 ENSMUSG00000137746 ENSMUST00000343301.1 ENSMUSG00000137746 (from geneSymbol) uc336wvx.1 uc336wvx.1 
ENSMUST00000343305.1 ENSMUSG00000137747 ENSMUST00000343305.1 ENSMUSG00000137747 (from geneSymbol) uc336wwb.1 uc336wwb.1 
ENSMUST00000343310.1 ENSMUSG00000137748 ENSMUST00000343310.1 ENSMUSG00000137748 (from geneSymbol) uc336wwg.1 uc336wwg.1 
ENSMUST00000343311.1 ENSMUSG00000137749 ENSMUST00000343311.1 ENSMUSG00000137749 (from geneSymbol) uc336wwh.1 uc336wwh.1 
ENSMUST00000343316.1 ENSMUSG00000137750 ENSMUST00000343316.1 ENSMUSG00000137750 (from geneSymbol) uc336wwm.1 uc336wwm.1 
ENSMUST00000343321.1 ENSMUSG00000137751 ENSMUST00000343321.1 ENSMUSG00000137751 (from geneSymbol) uc336wwr.1 uc336wwr.1 
ENSMUST00000343325.1 ENSMUSG00000137752 ENSMUST00000343325.1 ENSMUSG00000137752 (from geneSymbol) uc336wwv.1 uc336wwv.1 
ENSMUST00000343326.1 ENSMUSG00000137753 ENSMUST00000343326.1 ENSMUSG00000137753 (from geneSymbol) uc336www.1 uc336www.1 
ENSMUST00000343329.1 ENSMUSG00000137754 ENSMUST00000343329.1 ENSMUSG00000137754 (from geneSymbol) uc336wwz.1 uc336wwz.1 
ENSMUST00000343330.1 Gm35417 ENSMUST00000343330.1 Gm35417 (from geneSymbol) uc336wxa.1 uc336wxa.1 
ENSMUST00000343341.1 ENSMUSG00000137755 ENSMUST00000343341.1 ENSMUSG00000137755 (from geneSymbol) uc336wxl.1 uc336wxl.1 
ENSMUST00000343342.1 ENSMUSG00000137756 ENSMUST00000343342.1 ENSMUSG00000137756 (from geneSymbol) uc336wxm.1 uc336wxm.1 
ENSMUST00000343343.1 ENSMUSG00000137757 ENSMUST00000343343.1 ENSMUSG00000137757 (from geneSymbol) uc336wxn.1 uc336wxn.1 
ENSMUST00000343344.1 ENSMUSG00000137758 ENSMUST00000343344.1 ENSMUSG00000137758 (from geneSymbol) uc336wxo.1 uc336wxo.1 
ENSMUST00000343345.1 ENSMUSG00000137759 ENSMUST00000343345.1 ENSMUSG00000137759 (from geneSymbol) uc336wxp.1 uc336wxp.1 
ENSMUST00000343347.1 ENSMUSG00000137760 ENSMUST00000343347.1 ENSMUSG00000137760 (from geneSymbol) uc336wxr.1 uc336wxr.1 
ENSMUST00000343349.1 ENSMUSG00000137761 ENSMUST00000343349.1 ENSMUSG00000137761 (from geneSymbol) uc336wxt.1 uc336wxt.1 
ENSMUST00000343350.1 ENSMUSG00000137762 ENSMUST00000343350.1 ENSMUSG00000137762 (from geneSymbol) uc336wxu.1 uc336wxu.1 
ENSMUST00000343352.1 ENSMUSG00000137763 ENSMUST00000343352.1 ENSMUSG00000137763 (from geneSymbol) uc336wxw.1 uc336wxw.1 
ENSMUST00000343358.1 ENSMUSG00000137764 ENSMUST00000343358.1 ENSMUSG00000137764 (from geneSymbol) BC044871 uc336wyc.1 uc336wyc.1 
ENSMUST00000343367.1 ENSMUSG00000137765 ENSMUST00000343367.1 ENSMUSG00000137765 (from geneSymbol) uc336wyl.1 uc336wyl.1 
ENSMUST00000343375.1 ENSMUSG00000137767 ENSMUST00000343375.1 ENSMUSG00000137767 (from geneSymbol) uc336wyn.1 uc336wyn.1 
ENSMUST00000343376.1 ENSMUSG00000137768 ENSMUST00000343376.1 ENSMUSG00000137768 (from geneSymbol) uc336wyo.1 uc336wyo.1 
ENSMUST00000343380.1 Gm15987 ENSMUST00000343380.1 Gm15987 (from geneSymbol) AK157579 uc336wys.1 uc336wys.1 
ENSMUST00000343394.1 ENSMUSG00000137769 ENSMUST00000343394.1 ENSMUSG00000137769 (from geneSymbol) uc336wzg.1 uc336wzg.1 
ENSMUST00000343395.1 ENSMUSG00000137770 ENSMUST00000343395.1 ENSMUSG00000137770 (from geneSymbol) uc336wzh.1 uc336wzh.1 
ENSMUST00000343408.1 Gm45805 ENSMUST00000343408.1 Gm45805 (from geneSymbol) AK087657 uc336wzu.1 uc336wzu.1 
ENSMUST00000343421.1 Gm3587 ENSMUST00000343421.1 Gm3587 (from geneSymbol) uc336xah.1 uc336xah.1 
ENSMUST00000343460.1 ENSMUSG00000137771 ENSMUST00000343460.1 ENSMUSG00000137771 (from geneSymbol) uc336xbu.1 uc336xbu.1 
ENSMUST00000343461.1 ENSMUSG00000137772 ENSMUST00000343461.1 ENSMUSG00000137772 (from geneSymbol) uc336xbv.1 uc336xbv.1 
ENSMUST00000343462.1 8030453O22Rik ENSMUST00000343462.1 8030453O22Rik (from geneSymbol) AK047163 uc336xbw.1 uc336xbw.1 
ENSMUST00000343466.1 ENSMUSG00000137773 ENSMUST00000343466.1 ENSMUSG00000137773 (from geneSymbol) uc336xbz.1 uc336xbz.1 
ENSMUST00000343469.1 ENSMUSG00000137774 ENSMUST00000343469.1 ENSMUSG00000137774 (from geneSymbol) uc336xcc.1 uc336xcc.1 
ENSMUST00000343470.1 ENSMUSG00000137775 ENSMUST00000343470.1 ENSMUSG00000137775 (from geneSymbol) uc336xcd.1 uc336xcd.1 
ENSMUST00000343471.1 ENSMUSG00000137776 ENSMUST00000343471.1 ENSMUSG00000137776 (from geneSymbol) uc336xce.1 uc336xce.1 
ENSMUST00000343476.1 ENSMUSG00000137777 ENSMUST00000343476.1 ENSMUSG00000137777 (from geneSymbol) uc336xcj.1 uc336xcj.1 
ENSMUST00000343490.1 ENSMUSG00000137778 ENSMUST00000343490.1 ENSMUSG00000137778 (from geneSymbol) uc336xcx.1 uc336xcx.1 
ENSMUST00000343492.1 ENSMUSG00000137779 ENSMUST00000343492.1 ENSMUSG00000137779 (from geneSymbol) AK020597 uc336xcz.1 uc336xcz.1 
ENSMUST00000343514.1 ENSMUSG00000137780 ENSMUST00000343514.1 ENSMUSG00000137780 (from geneSymbol) uc336xdv.1 uc336xdv.1 
ENSMUST00000343515.1 Gm29946 ENSMUST00000343515.1 Gm29946 (from geneSymbol) uc336xdw.1 uc336xdw.1 
ENSMUST00000343523.1 ENSMUSG00000137781 ENSMUST00000343523.1 ENSMUSG00000137781 (from geneSymbol) uc336xee.1 uc336xee.1 
ENSMUST00000343525.1 ENSMUSG00000137782 ENSMUST00000343525.1 ENSMUSG00000137782 (from geneSymbol) uc336xeg.1 uc336xeg.1 
ENSMUST00000343526.1 ENSMUSG00000137783 ENSMUST00000343526.1 ENSMUSG00000137783 (from geneSymbol) uc336xeh.1 uc336xeh.1 
ENSMUST00000343527.1 ENSMUSG00000137784 ENSMUST00000343527.1 ENSMUSG00000137784 (from geneSymbol) uc336xei.1 uc336xei.1 
ENSMUST00000343528.1 ENSMUSG00000137785 ENSMUST00000343528.1 ENSMUSG00000137785 (from geneSymbol) uc336xej.1 uc336xej.1 
ENSMUST00000343536.1 ENSMUSG00000137786 ENSMUST00000343536.1 ENSMUSG00000137786 (from geneSymbol) uc336xer.1 uc336xer.1 
ENSMUST00000343543.1 ENSMUSG00000137787 ENSMUST00000343543.1 ENSMUSG00000137787 (from geneSymbol) uc336xey.1 uc336xey.1 
ENSMUST00000343545.1 ENSMUSG00000137788 ENSMUST00000343545.1 ENSMUSG00000137788 (from geneSymbol) uc336xfa.1 uc336xfa.1 
ENSMUST00000343546.1 ENSMUSG00000137789 ENSMUST00000343546.1 ENSMUSG00000137789 (from geneSymbol) uc336xfb.1 uc336xfb.1 
ENSMUST00000343549.1 Gm35722 ENSMUST00000343549.1 Gm35722 (from geneSymbol) AK042849 uc336xfe.1 uc336xfe.1 
ENSMUST00000343553.1 ENSMUSG00000137790 ENSMUST00000343553.1 ENSMUSG00000137790 (from geneSymbol) uc336xfi.1 uc336xfi.1 
ENSMUST00000343579.1 ENSMUSG00000137791 ENSMUST00000343579.1 ENSMUSG00000137791 (from geneSymbol) uc336xgi.1 uc336xgi.1 
ENSMUST00000343580.1 ENSMUSG00000137792 ENSMUST00000343580.1 ENSMUSG00000137792 (from geneSymbol) uc336xgj.1 uc336xgj.1 
ENSMUST00000343581.1 ENSMUSG00000137793 ENSMUST00000343581.1 ENSMUSG00000137793 (from geneSymbol) uc336xgk.1 uc336xgk.1 
ENSMUST00000343582.1 ENSMUSG00000137794 ENSMUST00000343582.1 ENSMUSG00000137794 (from geneSymbol) uc336xgl.1 uc336xgl.1 
ENSMUST00000343584.1 ENSMUSG00000137795 ENSMUST00000343584.1 ENSMUSG00000137795 (from geneSymbol) uc336xgn.1 uc336xgn.1 
ENSMUST00000343585.1 Gm49457 ENSMUST00000343585.1 Gm49457 (from geneSymbol) uc336xgo.1 uc336xgo.1 
ENSMUST00000343587.1 ENSMUSG00000137796 ENSMUST00000343587.1 ENSMUSG00000137796 (from geneSymbol) uc336xgq.1 uc336xgq.1 
ENSMUST00000343589.1 ENSMUSG00000137797 ENSMUST00000343589.1 ENSMUSG00000137797 (from geneSymbol) uc336xgs.1 uc336xgs.1 
ENSMUST00000343597.1 ENSMUSG00000137798 ENSMUST00000343597.1 ENSMUSG00000137798 (from geneSymbol) uc336xha.1 uc336xha.1 
ENSMUST00000343598.1 ENSMUSG00000121847 ENSMUST00000343598.1 ENSMUSG00000121847 (from geneSymbol) BC099969 uc336xhb.1 uc336xhb.1 
ENSMUST00000343602.1 ENSMUSG00000137799 ENSMUST00000343602.1 ENSMUSG00000137799 (from geneSymbol) uc336xhf.1 uc336xhf.1 
ENSMUST00000343603.1 ENSMUSG00000137800 ENSMUST00000343603.1 ENSMUSG00000137800 (from geneSymbol) uc336xhg.1 uc336xhg.1 
ENSMUST00000343604.1 ENSMUSG00000137801 ENSMUST00000343604.1 ENSMUSG00000137801 (from geneSymbol) AK085738 uc336xhh.1 uc336xhh.1 
ENSMUST00000343606.1 ENSMUSG00000137802 ENSMUST00000343606.1 ENSMUSG00000137802 (from geneSymbol) uc336xhj.1 uc336xhj.1 
ENSMUST00000343615.1 Gm38503 ENSMUST00000343615.1 Gm38503 (from geneSymbol) AK016513 uc336xhp.1 uc336xhp.1 
ENSMUST00000343686.1 Gm50336 ENSMUST00000343686.1 Gm50336 (from geneSymbol) uc336xjy.1 uc336xjy.1 
ENSMUST00000343689.1 4930503F20Rik ENSMUST00000343689.1 4930503F20Rik (from geneSymbol) AK019667 uc336xkb.1 uc336xkb.1 
ENSMUST00000343700.1 ENSMUSG00000137806 ENSMUST00000343700.1 ENSMUSG00000137806 (from geneSymbol) uc336xkm.1 uc336xkm.1 
ENSMUST00000343701.1 Gm56762 ENSMUST00000343701.1 Gm56762 (from geneSymbol) uc336xkn.1 uc336xkn.1 
ENSMUST00000343717.1 ENSMUSG00000137807 ENSMUST00000343717.1 ENSMUSG00000137807 (from geneSymbol) uc336xld.1 uc336xld.1 
ENSMUST00000343721.1 ENSMUSG00000137808 ENSMUST00000343721.1 ENSMUSG00000137808 (from geneSymbol) uc336xlh.1 uc336xlh.1 
ENSMUST00000343723.1 ENSMUSG00000137809 ENSMUST00000343723.1 ENSMUSG00000137809 (from geneSymbol) uc336xlj.1 uc336xlj.1 
ENSMUST00000343724.1 ENSMUSG00000137810 ENSMUST00000343724.1 ENSMUSG00000137810 (from geneSymbol) uc336xlk.1 uc336xlk.1 
ENSMUST00000343725.1 ENSMUSG00000137811 ENSMUST00000343725.1 ENSMUSG00000137811 (from geneSymbol) uc336xll.1 uc336xll.1 
ENSMUST00000343727.1 Gm21057 ENSMUST00000343727.1 Gm21057 (from geneSymbol) uc336xln.1 uc336xln.1 
ENSMUST00000343735.1 ENSMUSG00000137812 ENSMUST00000343735.1 ENSMUSG00000137812 (from geneSymbol) uc336xlv.1 uc336xlv.1 
ENSMUST00000343745.1 ENSMUSG00000137813 ENSMUST00000343745.1 ENSMUSG00000137813 (from geneSymbol) uc336xmf.1 uc336xmf.1 
ENSMUST00000343755.1 ENSMUSG00000137814 ENSMUST00000343755.1 ENSMUSG00000137814 (from geneSymbol) uc336xmp.1 uc336xmp.1 
ENSMUST00000343757.1 ENSMUSG00000137815 ENSMUST00000343757.1 ENSMUSG00000137815 (from geneSymbol) uc336xmr.1 uc336xmr.1 
ENSMUST00000343759.1 ENSMUSG00000137816 ENSMUST00000343759.1 ENSMUSG00000137816 (from geneSymbol) uc336xmt.1 uc336xmt.1 
ENSMUST00000343760.1 Gm49754 ENSMUST00000343760.1 Gm49754 (from geneSymbol) uc336xmu.1 uc336xmu.1 
ENSMUST00000343771.1 ENSMUSG00000137817 ENSMUST00000343771.1 ENSMUSG00000137817 (from geneSymbol) uc336xnf.1 uc336xnf.1 
ENSMUST00000343775.1 6530403H02Rik ENSMUST00000343775.1 6530403H02Rik (from geneSymbol) AK163681 uc336xnj.1 uc336xnj.1 
ENSMUST00000343819.1 ENSMUSG00000137818 ENSMUST00000343819.1 ENSMUSG00000137818 (from geneSymbol) uc336xpb.1 uc336xpb.1 
ENSMUST00000343821.1 ENSMUSG00000137819 ENSMUST00000343821.1 ENSMUSG00000137819 (from geneSymbol) uc336xpd.1 uc336xpd.1 
ENSMUST00000343822.1 Gm44176 ENSMUST00000343822.1 Gm44176 (from geneSymbol) uc336xpe.1 uc336xpe.1 
ENSMUST00000343823.1 ENSMUSG00000137820 ENSMUST00000343823.1 ENSMUSG00000137820 (from geneSymbol) uc336xpf.1 uc336xpf.1 
ENSMUST00000343825.1 ENSMUSG00000137821 ENSMUST00000343825.1 ENSMUSG00000137821 (from geneSymbol) uc336xph.1 uc336xph.1 
ENSMUST00000343826.1 ENSMUSG00000137822 ENSMUST00000343826.1 ENSMUSG00000137822 (from geneSymbol) uc336xpi.1 uc336xpi.1 
ENSMUST00000343827.1 ENSMUSG00000137823 ENSMUST00000343827.1 ENSMUSG00000137823 (from geneSymbol) uc336xpj.1 uc336xpj.1 
ENSMUST00000343829.1 ENSMUSG00000137824 ENSMUST00000343829.1 ENSMUSG00000137824 (from geneSymbol) uc336xpl.1 uc336xpl.1 
ENSMUST00000343831.1 ENSMUSG00000137825 ENSMUST00000343831.1 ENSMUSG00000137825 (from geneSymbol) uc336xpn.1 uc336xpn.1 
ENSMUST00000343832.1 ENSMUSG00000137826 ENSMUST00000343832.1 ENSMUSG00000137826 (from geneSymbol) uc336xpo.1 uc336xpo.1 
ENSMUST00000343834.1 ENSMUSG00000137827 ENSMUST00000343834.1 ENSMUSG00000137827 (from geneSymbol) uc336xpq.1 uc336xpq.1 
ENSMUST00000343836.1 ENSMUSG00000137828 ENSMUST00000343836.1 ENSMUSG00000137828 (from geneSymbol) uc336xps.1 uc336xps.1 
ENSMUST00000343855.1 ENSMUSG00000137829 ENSMUST00000343855.1 ENSMUSG00000137829 (from geneSymbol) uc336xql.1 uc336xql.1 
ENSMUST00000343857.1 ENSMUSG00000137831 ENSMUST00000343857.1 ENSMUSG00000137831 (from geneSymbol) uc336xqm.1 uc336xqm.1 
ENSMUST00000343861.1 Gm56966 ENSMUST00000343861.1 Gm56966 (from geneSymbol) uc336xqq.1 uc336xqq.1 
ENSMUST00000343865.1 ENSMUSG00000137832 ENSMUST00000343865.1 ENSMUSG00000137832 (from geneSymbol) uc336xqu.1 uc336xqu.1 
ENSMUST00000343866.1 Gm57077 ENSMUST00000343866.1 Gm57077 (from geneSymbol) AK135029 uc336xqv.1 uc336xqv.1 
ENSMUST00000343868.1 ENSMUSG00000137833 ENSMUST00000343868.1 ENSMUSG00000137833 (from geneSymbol) uc336xqx.1 uc336xqx.1 
ENSMUST00000343869.1 ENSMUSG00000137834 ENSMUST00000343869.1 ENSMUSG00000137834 (from geneSymbol) uc336xqy.1 uc336xqy.1 
ENSMUST00000343870.1 ENSMUSG00000137835 ENSMUST00000343870.1 ENSMUSG00000137835 (from geneSymbol) uc336xqz.1 uc336xqz.1 
ENSMUST00000343872.1 ENSMUSG00000137836 ENSMUST00000343872.1 ENSMUSG00000137836 (from geneSymbol) uc336xrb.1 uc336xrb.1 
ENSMUST00000343874.1 ENSMUSG00000137837 ENSMUST00000343874.1 ENSMUSG00000137837 (from geneSymbol) uc336xrd.1 uc336xrd.1 
ENSMUST00000343876.1 ENSMUSG00000137838 ENSMUST00000343876.1 ENSMUSG00000137838 (from geneSymbol) uc336xrf.1 uc336xrf.1 
ENSMUST00000343880.1 ENSMUSG00000137839 ENSMUST00000343880.1 ENSMUSG00000137839 (from geneSymbol) uc336xrj.1 uc336xrj.1 
ENSMUST00000343883.1 ENSMUSG00000137840 ENSMUST00000343883.1 ENSMUSG00000137840 (from geneSymbol) uc336xrm.1 uc336xrm.1 
ENSMUST00000343888.1 ENSMUSG00000137841 ENSMUST00000343888.1 ENSMUSG00000137841 (from geneSymbol) uc336xrr.1 uc336xrr.1 
ENSMUST00000343889.1 ENSMUSG00000137842 ENSMUST00000343889.1 ENSMUSG00000137842 (from geneSymbol) AK041649 uc336xrs.1 uc336xrs.1 
ENSMUST00000343891.1 Gm50335 ENSMUST00000343891.1 Gm50335 (from geneSymbol) uc336xru.1 uc336xru.1 
ENSMUST00000343900.1 ENSMUSG00000137843 ENSMUST00000343900.1 ENSMUSG00000137843 (from geneSymbol) uc336xsd.1 uc336xsd.1 
ENSMUST00000343902.1 ENSMUSG00000137844 ENSMUST00000343902.1 ENSMUSG00000137844 (from geneSymbol) uc336xsf.1 uc336xsf.1 
ENSMUST00000343903.1 ENSMUSG00000137845 ENSMUST00000343903.1 ENSMUSG00000137845 (from geneSymbol) uc336xsg.1 uc336xsg.1 
ENSMUST00000343904.1 ENSMUSG00000137846 ENSMUST00000343904.1 ENSMUSG00000137846 (from geneSymbol) LF198648 uc336xsh.1 uc336xsh.1 
ENSMUST00000343905.1 Gm12841 ENSMUST00000343905.1 predicted gene 12841 (from RefSeq NR_168719.1) NR_168719 uc336xsi.1 uc336xsi.1 
ENSMUST00000343918.1 ENSMUSG00000137847 ENSMUST00000343918.1 ENSMUSG00000137847 (from geneSymbol) uc336xsv.1 uc336xsv.1 
ENSMUST00000343933.1 ENSMUSG00000137848 ENSMUST00000343933.1 ENSMUSG00000137848 (from geneSymbol) AK135696 uc336xtk.1 uc336xtk.1 
ENSMUST00000343936.1 ENSMUSG00000137849 ENSMUST00000343936.1 ENSMUSG00000137849 (from geneSymbol) uc336xtn.1 uc336xtn.1 
ENSMUST00000343943.1 Rab10os ENSMUST00000343943.1 Rab10os (from geneSymbol) BC080728 uc336xtu.1 uc336xtu.1 
ENSMUST00000344019.1 ENSMUSG00000137850 ENSMUST00000344019.1 ENSMUSG00000137850 (from geneSymbol) uc336xwr.1 uc336xwr.1 
ENSMUST00000344020.1 ENSMUSG00000137851 ENSMUST00000344020.1 ENSMUSG00000137851 (from geneSymbol) uc336xws.1 uc336xws.1 
ENSMUST00000344021.1 ENSMUSG00000137852 ENSMUST00000344021.1 ENSMUSG00000137852 (from geneSymbol) uc336xwt.1 uc336xwt.1 
ENSMUST00000344024.1 4933409F18Rik ENSMUST00000344024.1 4933409F18Rik (from geneSymbol) AK016753 uc336xww.1 uc336xww.1 
ENSMUST00000344039.1 ENSMUSG00000137853 ENSMUST00000344039.1 ENSMUSG00000137853 (from geneSymbol) uc336xxl.1 uc336xxl.1 
ENSMUST00000344040.1 ENSMUSG00000137854 ENSMUST00000344040.1 ENSMUSG00000137854 (from geneSymbol) uc336xxm.1 uc336xxm.1 
ENSMUST00000344070.1 ENSMUSG00000137855 ENSMUST00000344070.1 ENSMUSG00000137855 (from geneSymbol) uc336xyq.1 uc336xyq.1 
ENSMUST00000344073.1 ENSMUSG00000137857 ENSMUST00000344073.1 ENSMUSG00000137857 (from geneSymbol) uc336xys.1 uc336xys.1 
ENSMUST00000344074.1 Gm56505 ENSMUST00000344074.1 Gm56505 (from geneSymbol) uc336xyt.1 uc336xyt.1 
ENSMUST00000344075.1 ENSMUSG00000137858 ENSMUST00000344075.1 ENSMUSG00000137858 (from geneSymbol) uc336xyu.1 uc336xyu.1 
ENSMUST00000344076.1 ENSMUSG00000137859 ENSMUST00000344076.1 ENSMUSG00000137859 (from geneSymbol) uc336xyv.1 uc336xyv.1 
ENSMUST00000344077.1 ENSMUSG00000137860 ENSMUST00000344077.1 ENSMUSG00000137860 (from geneSymbol) uc336xyw.1 uc336xyw.1 
ENSMUST00000344081.1 ENSMUSG00000137861 ENSMUST00000344081.1 ENSMUSG00000137861 (from geneSymbol) uc336xza.1 uc336xza.1 
ENSMUST00000344084.1 ENSMUSG00000137862 ENSMUST00000344084.1 ENSMUSG00000137862 (from geneSymbol) uc336xzd.1 uc336xzd.1 
ENSMUST00000344085.1 ENSMUSG00000137863 ENSMUST00000344085.1 ENSMUSG00000137863 (from geneSymbol) uc336xze.1 uc336xze.1 
ENSMUST00000344087.1 ENSMUSG00000137864 ENSMUST00000344087.1 ENSMUSG00000137864 (from geneSymbol) U96687 uc336xzg.1 uc336xzg.1 
ENSMUST00000344091.1 ENSMUSG00000137865 ENSMUST00000344091.1 ENSMUSG00000137865 (from geneSymbol) uc336xzk.1 uc336xzk.1 
ENSMUST00000344094.1 Gm49668 ENSMUST00000344094.1 Gm49668 (from geneSymbol) uc336xzn.1 uc336xzn.1 
ENSMUST00000344123.1 Gm56775 ENSMUST00000344123.1 Gm56775 (from geneSymbol) uc336yaq.1 uc336yaq.1 
ENSMUST00000344128.1 ENSMUSG00000137866 ENSMUST00000344128.1 ENSMUSG00000137866 (from geneSymbol) uc336yav.1 uc336yav.1 
ENSMUST00000344129.1 ENSMUSG00000137867 ENSMUST00000344129.1 ENSMUSG00000137867 (from geneSymbol) uc336yaw.1 uc336yaw.1 
ENSMUST00000344134.1 Gm46614 ENSMUST00000344134.1 Gm46614 (from geneSymbol) uc336ybb.1 uc336ybb.1 
ENSMUST00000344142.1 ENSMUSG00000137868 ENSMUST00000344142.1 ENSMUSG00000137868 (from geneSymbol) uc336ybj.1 uc336ybj.1 
ENSMUST00000344143.1 ENSMUSG00000137869 ENSMUST00000344143.1 ENSMUSG00000137869 (from geneSymbol) uc336ybk.1 uc336ybk.1 
ENSMUST00000344144.1 ENSMUSG00000137870 ENSMUST00000344144.1 ENSMUSG00000137870 (from geneSymbol) uc336ybl.1 uc336ybl.1 
ENSMUST00000344145.1 ENSMUSG00000137871 ENSMUST00000344145.1 ENSMUSG00000137871 (from geneSymbol) uc336ybm.1 uc336ybm.1 
ENSMUST00000344146.1 ENSMUSG00000137872 ENSMUST00000344146.1 ENSMUSG00000137872 (from geneSymbol) uc336ybn.1 uc336ybn.1 
ENSMUST00000344147.1 ENSMUSG00000137873 ENSMUST00000344147.1 ENSMUSG00000137873 (from geneSymbol) uc336ybo.1 uc336ybo.1 
ENSMUST00000344148.1 Gm39458 ENSMUST00000344148.1 Gm39458 (from geneSymbol) uc336ybp.1 uc336ybp.1 
ENSMUST00000344151.1 ENSMUSG00000137874 ENSMUST00000344151.1 ENSMUSG00000137874 (from geneSymbol) uc336ybs.1 uc336ybs.1 
ENSMUST00000344153.1 Etaa1os ENSMUST00000344153.1 Etaa1os (from geneSymbol) AK013680 uc336ybu.1 uc336ybu.1 
ENSMUST00000344169.1 ENSMUSG00000137875 ENSMUST00000344169.1 ENSMUSG00000137875 (from geneSymbol) AK046615 uc336yck.1 uc336yck.1 
ENSMUST00000344170.1 ENSMUSG00000137876 ENSMUST00000344170.1 ENSMUSG00000137876 (from geneSymbol) uc336ycl.1 uc336ycl.1 
ENSMUST00000344181.1 Gm41230 ENSMUST00000344181.1 Gm41230 (from geneSymbol) uc336ycw.1 uc336ycw.1 
ENSMUST00000344190.1 ENSMUSG00000137877 ENSMUST00000344190.1 ENSMUSG00000137877 (from geneSymbol) uc336ydf.1 uc336ydf.1 
ENSMUST00000344191.1 ENSMUSG00000137878 ENSMUST00000344191.1 ENSMUSG00000137878 (from geneSymbol) uc336ydg.1 uc336ydg.1 
ENSMUST00000344192.1 ENSMUSG00000137879 ENSMUST00000344192.1 ENSMUSG00000137879 (from geneSymbol) uc336ydh.1 uc336ydh.1 
ENSMUST00000344200.1 ENSMUSG00000137880 ENSMUST00000344200.1 ENSMUSG00000137880 (from geneSymbol) uc336ydp.1 uc336ydp.1 
ENSMUST00000344203.1 ENSMUSG00000137881 ENSMUST00000344203.1 ENSMUSG00000137881 (from geneSymbol) uc336yds.1 uc336yds.1 
ENSMUST00000344206.1 ENSMUSG00000137882 ENSMUST00000344206.1 ENSMUSG00000137882 (from geneSymbol) uc336ydv.1 uc336ydv.1 
ENSMUST00000344207.1 ENSMUSG00000137883 ENSMUST00000344207.1 ENSMUSG00000137883 (from geneSymbol) uc336ydw.1 uc336ydw.1 
ENSMUST00000344208.1 ENSMUSG00000137884 ENSMUST00000344208.1 ENSMUSG00000137884 (from geneSymbol) uc336ydx.1 uc336ydx.1 
ENSMUST00000344209.1 Gm48102 ENSMUST00000344209.1 Gm48102 (from geneSymbol) uc336ydy.1 uc336ydy.1 
ENSMUST00000344223.1 ENSMUSG00000137885 ENSMUST00000344223.1 ENSMUSG00000137885 (from geneSymbol) uc336yem.1 uc336yem.1 
ENSMUST00000344224.1 ENSMUSG00000137886 ENSMUST00000344224.1 ENSMUSG00000137886 (from geneSymbol) uc336yen.1 uc336yen.1 
ENSMUST00000344225.1 ENSMUSG00000137887 ENSMUST00000344225.1 ENSMUSG00000137887 (from geneSymbol) uc336yeo.1 uc336yeo.1 
ENSMUST00000344226.1 ENSMUSG00000137888 ENSMUST00000344226.1 ENSMUSG00000137888 (from geneSymbol) uc336yep.1 uc336yep.1 
ENSMUST00000344227.1 ENSMUSG00000137889 ENSMUST00000344227.1 ENSMUSG00000137889 (from geneSymbol) uc336yeq.1 uc336yeq.1 
ENSMUST00000344228.1 D130017N08Rik ENSMUST00000344228.1 D130017N08Rik (from geneSymbol) AK040221 uc336yer.1 uc336yer.1 
ENSMUST00000344233.1 ENSMUSG00000137890 ENSMUST00000344233.1 ENSMUSG00000137890 (from geneSymbol) uc336yew.1 uc336yew.1 
ENSMUST00000344234.1 ENSMUSG00000137891 ENSMUST00000344234.1 ENSMUSG00000137891 (from geneSymbol) uc336yex.1 uc336yex.1 
ENSMUST00000344238.1 Gm17088 ENSMUST00000344238.1 Gm17088 (from geneSymbol) uc336yfb.1 uc336yfb.1 
ENSMUST00000344243.1 ENSMUSG00000137892 ENSMUST00000344243.1 ENSMUSG00000137892 (from geneSymbol) uc336yfg.1 uc336yfg.1 
ENSMUST00000344249.1 ENSMUSG00000137893 ENSMUST00000344249.1 ENSMUSG00000137893 (from geneSymbol) uc336yfm.1 uc336yfm.1 
ENSMUST00000344252.1 ENSMUSG00000137894 ENSMUST00000344252.1 ENSMUSG00000137894 (from geneSymbol) uc336yfp.1 uc336yfp.1 
ENSMUST00000344253.1 ENSMUSG00000137895 ENSMUST00000344253.1 ENSMUSG00000137895 (from geneSymbol) uc336yfq.1 uc336yfq.1 
ENSMUST00000344259.1 ENSMUSG00000137896 ENSMUST00000344259.1 ENSMUSG00000137896 (from geneSymbol) uc336yfw.1 uc336yfw.1 
ENSMUST00000344264.1 ENSMUSG00000137897 ENSMUST00000344264.1 ENSMUSG00000137897 (from geneSymbol) BC099537 uc336ygb.1 uc336ygb.1 
ENSMUST00000344272.1 ENSMUSG00000137898 ENSMUST00000344272.1 ENSMUSG00000137898 (from geneSymbol) uc336ygj.1 uc336ygj.1 
ENSMUST00000344274.1 ENSMUSG00000137899 ENSMUST00000344274.1 ENSMUSG00000137899 (from geneSymbol) uc336ygl.1 uc336ygl.1 
ENSMUST00000344280.1 ENSMUSG00000137900 ENSMUST00000344280.1 ENSMUSG00000137900 (from geneSymbol) uc336ygr.1 uc336ygr.1 
ENSMUST00000344281.1 ENSMUSG00000137901 ENSMUST00000344281.1 ENSMUSG00000137901 (from geneSymbol) uc336ygs.1 uc336ygs.1 
ENSMUST00000344286.1 ENSMUSG00000137902 ENSMUST00000344286.1 ENSMUSG00000137902 (from geneSymbol) uc336ygx.1 uc336ygx.1 
ENSMUST00000344294.1 ENSMUSG00000137903 ENSMUST00000344294.1 ENSMUSG00000137903 (from geneSymbol) uc336yhf.1 uc336yhf.1 
ENSMUST00000344298.1 ENSMUSG00000137904 ENSMUST00000344298.1 ENSMUSG00000137904 (from geneSymbol) uc336yhj.1 uc336yhj.1 
ENSMUST00000344299.1 Gm30454 ENSMUST00000344299.1 Gm30454 (from geneSymbol) uc336yhk.1 uc336yhk.1 
ENSMUST00000344302.1 ENSMUSG00000137905 ENSMUST00000344302.1 ENSMUSG00000137905 (from geneSymbol) uc336yhn.1 uc336yhn.1 
ENSMUST00000344306.1 Gm42707 ENSMUST00000344306.1 Gm42707 (from geneSymbol) uc336yhr.1 uc336yhr.1 
ENSMUST00000344318.1 ENSMUSG00000137906 ENSMUST00000344318.1 ENSMUSG00000137906 (from geneSymbol) uc336yid.1 uc336yid.1 
ENSMUST00000344323.1 ENSMUSG00000137907 ENSMUST00000344323.1 ENSMUSG00000137907 (from geneSymbol) uc336yii.1 uc336yii.1 
ENSMUST00000344326.1 ENSMUSG00000137908 ENSMUST00000344326.1 ENSMUSG00000137908 (from geneSymbol) uc336yil.1 uc336yil.1 
ENSMUST00000344332.1 ENSMUSG00000137909 ENSMUST00000344332.1 ENSMUSG00000137909 (from geneSymbol) uc336yir.1 uc336yir.1 
ENSMUST00000344336.1 ENSMUSG00000137910 ENSMUST00000344336.1 ENSMUSG00000137910 (from geneSymbol) uc336yiv.1 uc336yiv.1 
ENSMUST00000344337.1 ENSMUSG00000137911 ENSMUST00000344337.1 ENSMUSG00000137911 (from geneSymbol) uc336yiw.1 uc336yiw.1 
ENSMUST00000344339.1 ENSMUSG00000137912 ENSMUST00000344339.1 ENSMUSG00000137912 (from geneSymbol) uc336yiy.1 uc336yiy.1 
ENSMUST00000344340.1 ENSMUSG00000137913 ENSMUST00000344340.1 ENSMUSG00000137913 (from geneSymbol) uc336yiz.1 uc336yiz.1 
ENSMUST00000344342.1 ENSMUSG00000137914 ENSMUST00000344342.1 ENSMUSG00000137914 (from geneSymbol) uc336yjb.1 uc336yjb.1 
ENSMUST00000344350.1 ENSMUSG00000137915 ENSMUST00000344350.1 ENSMUSG00000137915 (from geneSymbol) uc336yjj.1 uc336yjj.1 
ENSMUST00000344351.1 ENSMUSG00000137916 ENSMUST00000344351.1 ENSMUSG00000137916 (from geneSymbol) uc336yjk.1 uc336yjk.1 
ENSMUST00000344352.1 ENSMUSG00000137917 ENSMUST00000344352.1 ENSMUSG00000137917 (from geneSymbol) uc336yjl.1 uc336yjl.1 
ENSMUST00000344353.1 ENSMUSG00000137918 ENSMUST00000344353.1 ENSMUSG00000137918 (from geneSymbol) uc336yjm.1 uc336yjm.1 
ENSMUST00000344356.1 Gm28913 ENSMUST00000344356.1 Gm28913 (from geneSymbol) uc336yjo.1 uc336yjo.1 
ENSMUST00000344358.1 ENSMUSG00000137920 ENSMUST00000344358.1 ENSMUSG00000137920 (from geneSymbol) uc336yjq.1 uc336yjq.1 
ENSMUST00000344359.1 ENSMUSG00000137921 ENSMUST00000344359.1 ENSMUSG00000137921 (from geneSymbol) uc336yjr.1 uc336yjr.1 
ENSMUST00000344360.1 ENSMUSG00000137922 ENSMUST00000344360.1 ENSMUSG00000137922 (from geneSymbol) uc336yjs.1 uc336yjs.1 
ENSMUST00000344371.1 ENSMUSG00000137923 ENSMUST00000344371.1 predicted gene, 30927, transcript variant 1 (from RefSeq NR_168634.1) NR_168634 uc336ykd.1 uc336ykd.1 
ENSMUST00000344384.1 ENSMUSG00000137924 ENSMUST00000344384.1 ENSMUSG00000137924 (from geneSymbol) uc336ykq.1 uc336ykq.1 
ENSMUST00000344389.1 ENSMUSG00000137925 ENSMUST00000344389.1 ENSMUSG00000137925 (from geneSymbol) uc336ykv.1 uc336ykv.1 
ENSMUST00000344392.1 ENSMUSG00000137926 ENSMUST00000344392.1 ENSMUSG00000137926 (from geneSymbol) uc336yky.1 uc336yky.1 
ENSMUST00000344394.1 ENSMUSG00000137927 ENSMUST00000344394.1 ENSMUSG00000137927 (from geneSymbol) AK132659 uc336yla.1 uc336yla.1 
ENSMUST00000344395.1 ENSMUSG00000137928 ENSMUST00000344395.1 ENSMUSG00000137928 (from geneSymbol) uc336ylb.1 uc336ylb.1 
ENSMUST00000344403.1 ENSMUSG00000137929 ENSMUST00000344403.1 ENSMUSG00000137929 (from geneSymbol) uc336ylj.1 uc336ylj.1 
ENSMUST00000344404.1 ENSMUSG00000137930 ENSMUST00000344404.1 ENSMUSG00000137930 (from geneSymbol) uc336ylk.1 uc336ylk.1 
ENSMUST00000344408.1 Gm32688 ENSMUST00000344408.1 Gm32688 (from geneSymbol) AK144329 uc336ylo.1 uc336ylo.1 
ENSMUST00000344414.1 ENSMUSG00000137931 ENSMUST00000344414.1 ENSMUSG00000137931 (from geneSymbol) uc336ylu.1 uc336ylu.1 
ENSMUST00000344418.1 ENSMUSG00000137932 ENSMUST00000344418.1 ENSMUSG00000137932 (from geneSymbol) uc336yly.1 uc336yly.1 
ENSMUST00000344432.1 Far1os ENSMUST00000344432.1 Far1os (from geneSymbol) AK005686 uc336ymm.1 uc336ymm.1 
ENSMUST00000344436.1 ENSMUSG00000137933 ENSMUST00000344436.1 ENSMUSG00000137933 (from geneSymbol) uc336ymq.1 uc336ymq.1 
ENSMUST00000344437.1 ENSMUSG00000137934 ENSMUST00000344437.1 ENSMUSG00000137934 (from geneSymbol) uc336ymr.1 uc336ymr.1 
ENSMUST00000344438.1 ENSMUSG00000137935 ENSMUST00000344438.1 ENSMUSG00000137935 (from geneSymbol) uc336yms.1 uc336yms.1 
ENSMUST00000344439.1 ENSMUSG00000137936 ENSMUST00000344439.1 ENSMUSG00000137936 (from geneSymbol) uc336ymt.1 uc336ymt.1 
ENSMUST00000344440.1 ENSMUSG00000137937 ENSMUST00000344440.1 ENSMUSG00000137937 (from geneSymbol) uc336ymu.1 uc336ymu.1 
ENSMUST00000344481.1 Gm56555 ENSMUST00000344481.1 Gm56555 (from geneSymbol) uc336yoi.1 uc336yoi.1 
ENSMUST00000344483.1 Gm52870 ENSMUST00000344483.1 Gm52870 (from geneSymbol) uc336yok.1 uc336yok.1 
ENSMUST00000344489.1 Gm15499 ENSMUST00000344489.1 Gm15499 (from geneSymbol) uc336yoq.1 uc336yoq.1 
ENSMUST00000344490.1 ENSMUSG00000137938 ENSMUST00000344490.1 ENSMUSG00000137938 (from geneSymbol) uc336yor.1 uc336yor.1 
ENSMUST00000344491.1 Gm41562 ENSMUST00000344491.1 Gm41562 (from geneSymbol) uc336yos.1 uc336yos.1 
ENSMUST00000344495.1 ENSMUSG00000137939 ENSMUST00000344495.1 ENSMUSG00000137939 (from geneSymbol) uc336yow.1 uc336yow.1 
ENSMUST00000344522.1 ENSMUSG00000137940 ENSMUST00000344522.1 ENSMUSG00000137940 (from geneSymbol) uc336ypx.1 uc336ypx.1 
ENSMUST00000344529.1 ENSMUSG00000137941 ENSMUST00000344529.1 ENSMUSG00000137941 (from geneSymbol) uc336yqe.1 uc336yqe.1 
ENSMUST00000344530.1 ENSMUSG00000137942 ENSMUST00000344530.1 ENSMUSG00000137942 (from geneSymbol) uc336yqf.1 uc336yqf.1 
ENSMUST00000344531.1 ENSMUSG00000137943 ENSMUST00000344531.1 ENSMUSG00000137943 (from geneSymbol) uc336yqg.1 uc336yqg.1 
ENSMUST00000344535.1 2810029C07Rik ENSMUST00000344535.1 2810029C07Rik (from geneSymbol) BC024729 uc336yqk.1 uc336yqk.1 
ENSMUST00000344545.1 ENSMUSG00000137944 ENSMUST00000344545.1 ENSMUSG00000137944 (from geneSymbol) uc336yqu.1 uc336yqu.1 
ENSMUST00000344546.1 ENSMUSG00000137945 ENSMUST00000344546.1 ENSMUSG00000137945 (from geneSymbol) uc336yqv.1 uc336yqv.1 
ENSMUST00000344547.1 ENSMUSG00000137946 ENSMUST00000344547.1 ENSMUSG00000137946 (from geneSymbol) uc336yqw.1 uc336yqw.1 
ENSMUST00000344551.1 ENSMUSG00000137947 ENSMUST00000344551.1 ENSMUSG00000137947 (from geneSymbol) uc336yra.1 uc336yra.1 
ENSMUST00000344553.1 ENSMUSG00000137948 ENSMUST00000344553.1 ENSMUSG00000137948 (from geneSymbol) uc336yrc.1 uc336yrc.1 
ENSMUST00000344556.1 ENSMUSG00000137949 ENSMUST00000344556.1 ENSMUSG00000137949 (from geneSymbol) uc336yrf.1 uc336yrf.1 
ENSMUST00000344557.1 ENSMUSG00000137950 ENSMUST00000344557.1 ENSMUSG00000137950 (from geneSymbol) uc336yrg.1 uc336yrg.1 
ENSMUST00000344565.1 Gm29188 ENSMUST00000344565.1 Gm29188 (from geneSymbol) uc336yro.1 uc336yro.1 
ENSMUST00000344570.1 ENSMUSG00000137951 ENSMUST00000344570.1 ENSMUSG00000137951 (from geneSymbol) uc336yrt.1 uc336yrt.1 
ENSMUST00000344575.1 ENSMUSG00000137952 ENSMUST00000344575.1 ENSMUSG00000137952 (from geneSymbol) uc336yry.1 uc336yry.1 
ENSMUST00000344582.1 ENSMUSG00000137953 ENSMUST00000344582.1 ENSMUSG00000137953 (from geneSymbol) uc336ysf.1 uc336ysf.1 
ENSMUST00000344584.1 ENSMUSG00000137954 ENSMUST00000344584.1 ENSMUSG00000137954 (from geneSymbol) uc336ysh.1 uc336ysh.1 
ENSMUST00000344585.1 ENSMUSG00000137955 ENSMUST00000344585.1 ENSMUSG00000137955 (from geneSymbol) uc336ysi.1 uc336ysi.1 
ENSMUST00000344586.1 ENSMUSG00000137956 ENSMUST00000344586.1 ENSMUSG00000137956 (from geneSymbol) uc336ysj.1 uc336ysj.1 
ENSMUST00000344588.1 ENSMUSG00000137957 ENSMUST00000344588.1 ENSMUSG00000137957 (from geneSymbol) uc336ysl.1 uc336ysl.1 
ENSMUST00000344590.1 ENSMUSG00000137958 ENSMUST00000344590.1 ENSMUSG00000137958 (from geneSymbol) KY468021 uc336ysn.1 uc336ysn.1 
ENSMUST00000344594.1 ENSMUSG00000137959 ENSMUST00000344594.1 ENSMUSG00000137959 (from geneSymbol) uc336ysr.1 uc336ysr.1 
ENSMUST00000344600.1 Gm34726 ENSMUST00000344600.1 Gm34726 (from geneSymbol) uc336ysx.1 uc336ysx.1 
ENSMUST00000344608.1 ENSMUSG00000137960 ENSMUST00000344608.1 ENSMUSG00000137960 (from geneSymbol) uc336ytf.1 uc336ytf.1 
ENSMUST00000344610.1 ENSMUSG00000137961 ENSMUST00000344610.1 ENSMUSG00000137961 (from geneSymbol) uc336yth.1 uc336yth.1 
ENSMUST00000344613.1 ENSMUSG00000137962 ENSMUST00000344613.1 ENSMUSG00000137962 (from geneSymbol) uc336ytk.1 uc336ytk.1 
ENSMUST00000344615.1 ENSMUSG00000137963 ENSMUST00000344615.1 ENSMUSG00000137963 (from geneSymbol) uc336ytm.1 uc336ytm.1 
ENSMUST00000344618.1 ENSMUSG00000137964 ENSMUST00000344618.1 ENSMUSG00000137964 (from geneSymbol) uc336ytp.1 uc336ytp.1 
ENSMUST00000344622.1 ENSMUSG00000137965 ENSMUST00000344622.1 ENSMUSG00000137965 (from geneSymbol) uc336ytt.1 uc336ytt.1 
ENSMUST00000344623.1 ENSMUSG00000137966 ENSMUST00000344623.1 ENSMUSG00000137966 (from geneSymbol) uc336ytu.1 uc336ytu.1 
ENSMUST00000344624.1 ENSMUSG00000137967 ENSMUST00000344624.1 ENSMUSG00000137967 (from geneSymbol) uc336ytv.1 uc336ytv.1 
ENSMUST00000344625.1 Gm33682 ENSMUST00000344625.1 Gm33682 (from geneSymbol) uc336ytw.1 uc336ytw.1 
ENSMUST00000344628.1 ENSMUSG00000137968 ENSMUST00000344628.1 ENSMUSG00000137968 (from geneSymbol) uc336ytz.1 uc336ytz.1 
ENSMUST00000344631.1 ENSMUSG00000137969 ENSMUST00000344631.1 ENSMUSG00000137969 (from geneSymbol) uc336yuc.1 uc336yuc.1 
ENSMUST00000344632.1 ENSMUSG00000137970 ENSMUST00000344632.1 ENSMUSG00000137970 (from geneSymbol) uc336yud.1 uc336yud.1 
ENSMUST00000344633.1 Gm56532 ENSMUST00000344633.1 Gm56532 (from geneSymbol) uc336yue.1 uc336yue.1 
ENSMUST00000344635.1 ENSMUSG00000137971 ENSMUST00000344635.1 ENSMUSG00000137971 (from geneSymbol) uc336yug.1 uc336yug.1 
ENSMUST00000344639.1 ENSMUSG00000137972 ENSMUST00000344639.1 ENSMUSG00000137972 (from geneSymbol) uc336yuk.1 uc336yuk.1 
ENSMUST00000344644.1 ENSMUSG00000137973 ENSMUST00000344644.1 ENSMUSG00000137973 (from geneSymbol) uc336yup.1 uc336yup.1 
ENSMUST00000344650.1 Gm56931 ENSMUST00000344650.1 Gm56931 (from geneSymbol) uc336yuv.1 uc336yuv.1 
ENSMUST00000344663.1 Gm20705 ENSMUST00000344663.1 Gm20705 (from geneSymbol) AK042037 uc336yvi.1 uc336yvi.1 
ENSMUST00000344665.1 ENSMUSG00000137974 ENSMUST00000344665.1 ENSMUSG00000137974 (from geneSymbol) uc336yvk.1 uc336yvk.1 
ENSMUST00000344669.1 ENSMUSG00000137975 ENSMUST00000344669.1 ENSMUSG00000137975 (from geneSymbol) uc336yvo.1 uc336yvo.1 
ENSMUST00000344670.1 ENSMUSG00000137976 ENSMUST00000344670.1 ENSMUSG00000137976 (from geneSymbol) uc336yvp.1 uc336yvp.1 
ENSMUST00000344681.1 Gm14266 ENSMUST00000344681.1 Gm14266 (from geneSymbol) BC049717 uc336yvz.1 uc336yvz.1 
ENSMUST00000344727.1 ENSMUSG00000137978 ENSMUST00000344727.1 ENSMUSG00000137978 (from geneSymbol) uc336yxt.1 uc336yxt.1 
ENSMUST00000344728.1 Gm32531 ENSMUST00000344728.1 Gm32531 (from geneSymbol) uc336yxu.1 uc336yxu.1 
ENSMUST00000344734.1 Gm31925 ENSMUST00000344734.1 Gm31925 (from geneSymbol) AK135878 uc336yya.1 uc336yya.1 
ENSMUST00000344785.1 ENSMUSG00000137979 ENSMUST00000344785.1 ENSMUSG00000137979 (from geneSymbol) uc336yzz.1 uc336yzz.1 
ENSMUST00000344788.1 ENSMUSG00000137980 ENSMUST00000344788.1 ENSMUSG00000137980 (from geneSymbol) uc336zac.1 uc336zac.1 
ENSMUST00000344789.1 ENSMUSG00000137981 ENSMUST00000344789.1 ENSMUSG00000137981 (from geneSymbol) uc336zad.1 uc336zad.1 
ENSMUST00000344791.1 Gm5922 ENSMUST00000344791.1 Gm5922 (from geneSymbol) AK076698 uc336zaf.1 uc336zaf.1 
ENSMUST00000344797.1 ENSMUSG00000137982 ENSMUST00000344797.1 ENSMUSG00000137982 (from geneSymbol) uc336zal.1 uc336zal.1 
ENSMUST00000344800.1 Gm10827 ENSMUST00000344800.1 Gm10827 (from geneSymbol) uc336zan.1 uc336zan.1 
ENSMUST00000344806.1 ENSMUSG00000137983 ENSMUST00000344806.1 ENSMUSG00000137983 (from geneSymbol) uc336zat.1 uc336zat.1 
ENSMUST00000344809.1 C230037L18Rik ENSMUST00000344809.1 C230037L18Rik (from geneSymbol) AK082325 uc336zaw.1 uc336zaw.1 
ENSMUST00000344857.1 ENSMUSG00000137984 ENSMUST00000344857.1 ENSMUSG00000137984 (from geneSymbol) uc336zcs.1 uc336zcs.1 
ENSMUST00000344858.1 ENSMUSG00000137985 ENSMUST00000344858.1 ENSMUSG00000137985 (from geneSymbol) uc336zct.1 uc336zct.1 
ENSMUST00000344860.1 ENSMUSG00000137986 ENSMUST00000344860.1 ENSMUSG00000137986 (from geneSymbol) uc336zcv.1 uc336zcv.1 
ENSMUST00000344869.1 ENSMUSG00000137987 ENSMUST00000344869.1 ENSMUSG00000137987 (from geneSymbol) uc336zde.1 uc336zde.1 
ENSMUST00000344876.1 ENSMUSG00000137988 ENSMUST00000344876.1 ENSMUSG00000137988 (from geneSymbol) uc336zdl.1 uc336zdl.1 
ENSMUST00000344882.1 ENSMUSG00000137989 ENSMUST00000344882.1 ENSMUSG00000137989 (from geneSymbol) uc336zdq.1 uc336zdq.1 
ENSMUST00000344887.1 ENSMUSG00000137990 ENSMUST00000344887.1 ENSMUSG00000137990 (from geneSymbol) uc336zdv.1 uc336zdv.1 
ENSMUST00000344900.1 ENSMUSG00000137991 ENSMUST00000344900.1 ENSMUSG00000137991 (from geneSymbol) uc336zei.1 uc336zei.1 
ENSMUST00000344901.1 ENSMUSG00000137992 ENSMUST00000344901.1 ENSMUSG00000137992 (from geneSymbol) uc336zej.1 uc336zej.1 
ENSMUST00000344903.1 ENSMUSG00000137993 ENSMUST00000344903.1 ENSMUSG00000137993 (from geneSymbol) LF192854 uc336zel.1 uc336zel.1 
ENSMUST00000344904.1 ENSMUSG00000137994 ENSMUST00000344904.1 ENSMUSG00000137994 (from geneSymbol) uc336zem.1 uc336zem.1 
ENSMUST00000344906.1 ENSMUSG00000137995 ENSMUST00000344906.1 ENSMUSG00000137995 (from geneSymbol) uc336zeo.1 uc336zeo.1 
ENSMUST00000344909.1 BC051408 ENSMUST00000344909.1 BC051408 (from geneSymbol) uc336zer.1 uc336zer.1 
ENSMUST00000344912.1 Gm56958 ENSMUST00000344912.1 Gm56958 (from geneSymbol) uc336zeu.1 uc336zeu.1 
ENSMUST00000344920.1 ENSMUSG00000137996 ENSMUST00000344920.1 ENSMUSG00000137996 (from geneSymbol) uc336zfc.1 uc336zfc.1 
ENSMUST00000344924.1 ENSMUSG00000137997 ENSMUST00000344924.1 ENSMUSG00000137997 (from geneSymbol) AK018905 uc336zfg.1 uc336zfg.1 
ENSMUST00000344939.1 ENSMUSG00000137998 ENSMUST00000344939.1 ENSMUSG00000137998 (from geneSymbol) uc336zfv.1 uc336zfv.1 
ENSMUST00000344940.1 ENSMUSG00000137999 ENSMUST00000344940.1 ENSMUSG00000137999 (from geneSymbol) uc336zfw.1 uc336zfw.1 
ENSMUST00000344944.1 ENSMUSG00000138000 ENSMUST00000344944.1 ENSMUSG00000138000 (from geneSymbol) uc336zga.1 uc336zga.1 
ENSMUST00000344950.1 ENSMUSG00000138001 ENSMUST00000344950.1 ENSMUSG00000138001 (from geneSymbol) uc336zgg.1 uc336zgg.1 
ENSMUST00000344951.1 ENSMUSG00000138002 ENSMUST00000344951.1 ENSMUSG00000138002 (from geneSymbol) uc336zgh.1 uc336zgh.1 
ENSMUST00000344952.1 ENSMUSG00000138003 ENSMUST00000344952.1 ENSMUSG00000138003 (from geneSymbol) uc336zgi.1 uc336zgi.1 
ENSMUST00000344953.1 ENSMUSG00000138004 ENSMUST00000344953.1 ENSMUSG00000138004 (from geneSymbol) uc336zgj.1 uc336zgj.1 
ENSMUST00000344954.1 ENSMUSG00000138005 ENSMUST00000344954.1 ENSMUSG00000138005 (from geneSymbol) uc336zgk.1 uc336zgk.1 
ENSMUST00000344964.1 B230110C06Rik ENSMUST00000344964.1 B230110C06Rik (from geneSymbol) AK020961 uc336zgu.1 uc336zgu.1 
ENSMUST00000344981.1 ENSMUSG00000138006 ENSMUST00000344981.1 ENSMUSG00000138006 (from geneSymbol) uc336zhl.1 uc336zhl.1 
ENSMUST00000344982.1 ENSMUSG00000138007 ENSMUST00000344982.1 ENSMUSG00000138007 (from geneSymbol) uc336zhm.1 uc336zhm.1 
ENSMUST00000344985.1 ENSMUSG00000138009 ENSMUST00000344985.1 ENSMUSG00000138009 (from geneSymbol) uc336zho.1 uc336zho.1 
ENSMUST00000344986.1 ENSMUSG00000138010 ENSMUST00000344986.1 ENSMUSG00000138010 (from geneSymbol) uc336zhp.1 uc336zhp.1 
ENSMUST00000344987.1 ENSMUSG00000138011 ENSMUST00000344987.1 ENSMUSG00000138011 (from geneSymbol) uc336zhq.1 uc336zhq.1 
ENSMUST00000344988.1 1700018P08Rik ENSMUST00000344988.1 1700018P08Rik (from geneSymbol) AK006097 uc336zhr.1 uc336zhr.1 
ENSMUST00000344990.1 ENSMUSG00000138012 ENSMUST00000344990.1 ENSMUSG00000138012 (from geneSymbol) AK016424 uc336zht.1 uc336zht.1 
ENSMUST00000344996.1 ENSMUSG00000138013 ENSMUST00000344996.1 ENSMUSG00000138013 (from geneSymbol) DQ558694 uc336zhz.1 uc336zhz.1 
ENSMUST00000344997.1 Gm57426 ENSMUST00000344997.1 Gm57426 (from geneSymbol) uc336zia.1 uc336zia.1 
ENSMUST00000344999.1 ENSMUSG00000138014 ENSMUST00000344999.1 ENSMUSG00000138014 (from geneSymbol) uc336zic.1 uc336zic.1 
ENSMUST00000345001.1 ENSMUSG00000138015 ENSMUST00000345001.1 ENSMUSG00000138015 (from geneSymbol) uc336zie.1 uc336zie.1 
ENSMUST00000345002.1 1600027J07Rik ENSMUST00000345002.1 1600027J07Rik (from geneSymbol) AK005548 uc336zif.1 uc336zif.1 
ENSMUST00000345008.1 ENSMUSG00000138016 ENSMUST00000345008.1 ENSMUSG00000138016 (from geneSymbol) uc336zil.1 uc336zil.1 
ENSMUST00000345013.1 ENSMUSG00000138017 ENSMUST00000345013.1 ENSMUSG00000138017 (from geneSymbol) uc336ziq.1 uc336ziq.1 
ENSMUST00000345015.1 ENSMUSG00000138018 ENSMUST00000345015.1 ENSMUSG00000138018 (from geneSymbol) uc336zis.1 uc336zis.1 
ENSMUST00000345016.1 ENSMUSG00000138019 ENSMUST00000345016.1 ENSMUSG00000138019 (from geneSymbol) uc336zit.1 uc336zit.1 
ENSMUST00000345021.1 ENSMUSG00000138021 ENSMUST00000345021.1 ENSMUSG00000138021 (from geneSymbol) uc336zix.1 uc336zix.1 
ENSMUST00000345023.1 ENSMUSG00000138022 ENSMUST00000345023.1 ENSMUSG00000138022 (from geneSymbol) uc336ziz.1 uc336ziz.1 
ENSMUST00000345029.1 ENSMUSG00000138023 ENSMUST00000345029.1 ENSMUSG00000138023 (from geneSymbol) uc336zjf.1 uc336zjf.1 
ENSMUST00000345031.1 ENSMUSG00000138024 ENSMUST00000345031.1 ENSMUSG00000138024 (from geneSymbol) uc336zjh.1 uc336zjh.1 
ENSMUST00000345033.1 ENSMUSG00000138025 ENSMUST00000345033.1 ENSMUSG00000138025 (from geneSymbol) uc336zjj.1 uc336zjj.1 
ENSMUST00000345034.1 ENSMUSG00000138026 ENSMUST00000345034.1 ENSMUSG00000138026 (from geneSymbol) uc336zjk.1 uc336zjk.1 
ENSMUST00000345037.1 ENSMUSG00000138027 ENSMUST00000345037.1 ENSMUSG00000138027 (from geneSymbol) uc336zjn.1 uc336zjn.1 
ENSMUST00000345038.1 ENSMUSG00000138028 ENSMUST00000345038.1 ENSMUSG00000138028 (from geneSymbol) uc336zjo.1 uc336zjo.1 
ENSMUST00000345040.1 ENSMUSG00000138029 ENSMUST00000345040.1 ENSMUSG00000138029 (from geneSymbol) uc336zjq.1 uc336zjq.1 
ENSMUST00000345041.1 ENSMUSG00000138030 ENSMUST00000345041.1 ENSMUSG00000138030 (from geneSymbol) AK015519 uc336zjr.1 uc336zjr.1 
ENSMUST00000345044.1 ENSMUSG00000138031 ENSMUST00000345044.1 ENSMUSG00000138031 (from geneSymbol) uc336zju.1 uc336zju.1 
ENSMUST00000345046.1 ENSMUSG00000138032 ENSMUST00000345046.1 ENSMUSG00000138032 (from geneSymbol) uc336zjw.1 uc336zjw.1 
ENSMUST00000345052.1 1700048O14Rik ENSMUST00000345052.1 1700048O14Rik (from geneSymbol) AK006733 uc336zkc.1 uc336zkc.1 
ENSMUST00000345066.1 ENSMUSG00000138033 ENSMUST00000345066.1 ENSMUSG00000138033 (from geneSymbol) AK018905 uc336zkq.1 uc336zkq.1 
ENSMUST00000345089.1 ENSMUSG00000138034 ENSMUST00000345089.1 ENSMUSG00000138034 (from geneSymbol) uc336zln.1 uc336zln.1 
ENSMUST00000345090.1 ENSMUSG00000138035 ENSMUST00000345090.1 ENSMUSG00000138035 (from geneSymbol) uc336zlo.1 uc336zlo.1 
ENSMUST00000345119.1 Rny1 ENSMUST00000345119.1 RNA, Y1 small cytoplasmic, Ro-associated (from RefSeq NR_004419.1) NR_004419 uc336zmr.1 uc336zmr.1 
ENSMUST00000345120.1 ENSMUSG00000138037 ENSMUST00000345120.1 ENSMUSG00000138037 (from geneSymbol) LF192583 uc336zms.1 uc336zms.1 
ENSMUST00000345122.1 Gm33524 ENSMUST00000345122.1 Gm33524 (from geneSymbol) uc336zmu.1 uc336zmu.1 
ENSMUST00000345141.1 ENSMUSG00000138038 ENSMUST00000345141.1 ENSMUSG00000138038 (from geneSymbol) uc336znn.1 uc336znn.1 
ENSMUST00000345143.1 ENSMUSG00000138039 ENSMUST00000345143.1 ENSMUSG00000138039 (from geneSymbol) uc336znp.1 uc336znp.1 
ENSMUST00000345148.1 ENSMUSG00000138040 ENSMUST00000345148.1 ENSMUSG00000138040 (from geneSymbol) uc336znu.1 uc336znu.1 
ENSMUST00000345152.1 ENSMUSG00000138041 ENSMUST00000345152.1 ENSMUSG00000138041 (from geneSymbol) uc336zny.1 uc336zny.1 
ENSMUST00000345154.1 ENSMUSG00000138043 ENSMUST00000345154.1 ENSMUSG00000138043 (from geneSymbol) uc336znz.1 uc336znz.1 
ENSMUST00000345158.1 Gm49106 ENSMUST00000345158.1 Gm49106 (from geneSymbol) uc336zod.1 uc336zod.1 
ENSMUST00000345165.1 ENSMUSG00000138044 ENSMUST00000345165.1 ENSMUSG00000138044 (from geneSymbol) uc336zok.1 uc336zok.1 
ENSMUST00000345166.1 Gm44767 ENSMUST00000345166.1 Gm44767 (from geneSymbol) AK005849 uc336zol.1 uc336zol.1 
ENSMUST00000345174.1 ENSMUSG00000121746 ENSMUST00000345174.1 ENSMUSG00000121746 (from geneSymbol) AK005849 uc336zos.1 uc336zos.1 
ENSMUST00000345232.1 4933406J10Rik ENSMUST00000345232.1 4933406J10Rik (from geneSymbol) AK016697 uc336zqy.1 uc336zqy.1 
ENSMUST00000345237.1 ENSMUSG00000138045 ENSMUST00000345237.1 ENSMUSG00000138045 (from geneSymbol) uc336zrd.1 uc336zrd.1 
ENSMUST00000345238.1 ENSMUSG00000138046 ENSMUST00000345238.1 ENSMUSG00000138046 (from geneSymbol) uc336zre.1 uc336zre.1 
ENSMUST00000345242.1 ENSMUSG00000138047 ENSMUST00000345242.1 ENSMUSG00000138047 (from geneSymbol) uc336zri.1 uc336zri.1 
ENSMUST00000345250.1 ENSMUSG00000121716 ENSMUST00000345250.1 ENSMUSG00000121716 (from geneSymbol) AK080657 uc336zrq.1 uc336zrq.1 
ENSMUST00000345256.1 ENSMUSG00000138049 ENSMUST00000345256.1 ENSMUSG00000138049 (from geneSymbol) uc336zrv.1 uc336zrv.1 
ENSMUST00000345257.1 ENSMUSG00000138050 ENSMUST00000345257.1 ENSMUSG00000138050 (from geneSymbol) uc336zrw.1 uc336zrw.1 
ENSMUST00000345258.1 ENSMUSG00000138051 ENSMUST00000345258.1 ENSMUSG00000138051 (from geneSymbol) uc336zrx.1 uc336zrx.1 
ENSMUST00000345259.1 ENSMUSG00000138052 ENSMUST00000345259.1 ENSMUSG00000138052 (from geneSymbol) uc336zry.1 uc336zry.1 
ENSMUST00000345264.1 ENSMUSG00000138053 ENSMUST00000345264.1 ENSMUSG00000138053 (from geneSymbol) uc336zsd.1 uc336zsd.1 
ENSMUST00000345265.1 ENSMUSG00000138054 ENSMUST00000345265.1 ENSMUSG00000138054 (from geneSymbol) uc336zse.1 uc336zse.1 
ENSMUST00000345266.1 ENSMUSG00000138055 ENSMUST00000345266.1 ENSMUSG00000138055 (from geneSymbol) uc336zsf.1 uc336zsf.1 
ENSMUST00000345269.1 ENSMUSG00000138056 ENSMUST00000345269.1 ENSMUSG00000138056 (from geneSymbol) uc336zsi.1 uc336zsi.1 
ENSMUST00000345272.1 ENSMUSG00000138057 ENSMUST00000345272.1 ENSMUSG00000138057 (from geneSymbol) uc336zsl.1 uc336zsl.1 
ENSMUST00000345281.1 ENSMUSG00000138059 ENSMUST00000345281.1 ENSMUSG00000138059 (from geneSymbol) uc336zst.1 uc336zst.1 
ENSMUST00000345283.1 ENSMUSG00000138060 ENSMUST00000345283.1 ENSMUSG00000138060 (from geneSymbol) uc336zsv.1 uc336zsv.1 
ENSMUST00000345285.1 ENSMUSG00000138061 ENSMUST00000345285.1 ENSMUSG00000138061 (from geneSymbol) uc336zsx.1 uc336zsx.1 
ENSMUST00000345287.1 ENSMUSG00000138062 ENSMUST00000345287.1 ENSMUSG00000138062 (from geneSymbol) uc336zsz.1 uc336zsz.1 
ENSMUST00000345289.1 ENSMUSG00000138063 ENSMUST00000345289.1 ENSMUSG00000138063 (from geneSymbol) uc336ztb.1 uc336ztb.1 
ENSMUST00000345291.1 Gm13465 ENSMUST00000345291.1 Gm13465 (from geneSymbol) AK006114 uc336ztd.1 uc336ztd.1 
ENSMUST00000345293.1 ENSMUSG00000138064 ENSMUST00000345293.1 ENSMUSG00000138064 (from geneSymbol) uc336ztf.1 uc336ztf.1 
ENSMUST00000345342.1 ENSMUSG00000138065 ENSMUST00000345342.1 ENSMUSG00000138065 (from geneSymbol) uc336zuo.1 uc336zuo.1 
ENSMUST00000345348.1 ENSMUSG00000138066 ENSMUST00000345348.1 ENSMUSG00000138066 (from geneSymbol) uc336zut.1 uc336zut.1 
ENSMUST00000345349.1 ENSMUSG00000138067 ENSMUST00000345349.1 ENSMUSG00000138067 (from geneSymbol) LF196172 uc336zuu.1 uc336zuu.1 
ENSMUST00000345353.1 Gm4265 ENSMUST00000345353.1 Gm4265 (from geneSymbol) uc336zuy.1 uc336zuy.1 
ENSMUST00000345378.1 ENSMUSG00000138068 ENSMUST00000345378.1 ENSMUSG00000138068 (from geneSymbol) uc336zvx.1 uc336zvx.1 
ENSMUST00000345379.1 ENSMUSG00000138069 ENSMUST00000345379.1 ENSMUSG00000138069 (from geneSymbol) uc336zvy.1 uc336zvy.1 
ENSMUST00000345380.1 ENSMUSG00000138070 ENSMUST00000345380.1 ENSMUSG00000138070 (from geneSymbol) uc336zvz.1 uc336zvz.1 
ENSMUST00000345381.1 ENSMUSG00000138071 ENSMUST00000345381.1 ENSMUSG00000138071 (from geneSymbol) uc336zwa.1 uc336zwa.1 
ENSMUST00000345383.1 ENSMUSG00000138072 ENSMUST00000345383.1 ENSMUSG00000138072 (from geneSymbol) uc336zwc.1 uc336zwc.1 
ENSMUST00000345384.1 ENSMUSG00000138073 ENSMUST00000345384.1 ENSMUSG00000138073 (from geneSymbol) uc336zwd.1 uc336zwd.1 
ENSMUST00000345385.1 ENSMUSG00000138074 ENSMUST00000345385.1 ENSMUSG00000138074 (from geneSymbol) uc336zwe.1 uc336zwe.1 
ENSMUST00000345386.1 ENSMUSG00000138075 ENSMUST00000345386.1 ENSMUSG00000138075 (from geneSymbol) uc336zwf.1 uc336zwf.1 
ENSMUST00000345392.1 ENSMUSG00000138076 ENSMUST00000345392.1 ENSMUSG00000138076 (from geneSymbol) uc336zwk.1 uc336zwk.1 
ENSMUST00000345396.1 ENSMUSG00000138077 ENSMUST00000345396.1 ENSMUSG00000138077 (from geneSymbol) uc336zwo.1 uc336zwo.1 
ENSMUST00000345401.1 ENSMUSG00000138078 ENSMUST00000345401.1 ENSMUSG00000138078 (from geneSymbol) uc336zwt.1 uc336zwt.1 
ENSMUST00000345404.1 ENSMUSG00000138079 ENSMUST00000345404.1 ENSMUSG00000138079 (from geneSymbol) uc336zww.1 uc336zww.1 
ENSMUST00000345405.1 ENSMUSG00000138080 ENSMUST00000345405.1 ENSMUSG00000138080 (from geneSymbol) uc336zwx.1 uc336zwx.1 
ENSMUST00000345406.1 ENSMUSG00000138081 ENSMUST00000345406.1 ENSMUSG00000138081 (from geneSymbol) uc336zwy.1 uc336zwy.1 
ENSMUST00000345407.1 ENSMUSG00000138082 ENSMUST00000345407.1 ENSMUSG00000138082 (from geneSymbol) uc336zwz.1 uc336zwz.1 
ENSMUST00000345408.1 ENSMUSG00000138083 ENSMUST00000345408.1 ENSMUSG00000138083 (from geneSymbol) uc336zxa.1 uc336zxa.1 
ENSMUST00000345438.1 ENSMUSG00000138084 ENSMUST00000345438.1 ENSMUSG00000138084 (from geneSymbol) uc336zye.1 uc336zye.1 
ENSMUST00000345439.1 ENSMUSG00000138085 ENSMUST00000345439.1 ENSMUSG00000138085 (from geneSymbol) uc336zyf.1 uc336zyf.1 
ENSMUST00000345445.1 ENSMUSG00000138086 ENSMUST00000345445.1 ENSMUSG00000138086 (from geneSymbol) uc336zyk.1 uc336zyk.1 
ENSMUST00000345447.1 ENSMUSG00000138087 ENSMUST00000345447.1 ENSMUSG00000138087 (from geneSymbol) uc336zym.1 uc336zym.1 
ENSMUST00000345448.1 Gm49107 ENSMUST00000345448.1 Gm49107 (from geneSymbol) uc336zyn.1 uc336zyn.1 
ENSMUST00000345454.1 Gm47082 ENSMUST00000345454.1 Gm47082 (from geneSymbol) uc336zyt.1 uc336zyt.1 
ENSMUST00000345456.1 ENSMUSG00000138088 ENSMUST00000345456.1 ENSMUSG00000138088 (from geneSymbol) uc336zyv.1 uc336zyv.1 
ENSMUST00000345457.1 ENSMUSG00000138089 ENSMUST00000345457.1 ENSMUSG00000138089 (from geneSymbol) uc336zyw.1 uc336zyw.1 
ENSMUST00000345460.1 ENSMUSG00000138090 ENSMUST00000345460.1 ENSMUSG00000138090 (from geneSymbol) uc336zyz.1 uc336zyz.1 
ENSMUST00000345461.1 ENSMUSG00000138091 ENSMUST00000345461.1 ENSMUSG00000138091 (from geneSymbol) uc336zza.1 uc336zza.1 
ENSMUST00000345485.1 ENSMUSG00000138092 ENSMUST00000345485.1 ENSMUSG00000138092 (from geneSymbol) uc336zzy.1 uc336zzy.1 
ENSMUST00000345486.1 ENSMUSG00000138093 ENSMUST00000345486.1 ENSMUSG00000138093 (from geneSymbol) uc336zzz.1 uc336zzz.1 
ENSMUST00000345498.1 ENSMUSG00000138094 ENSMUST00000345498.1 ENSMUSG00000138094 (from geneSymbol) uc337aal.1 uc337aal.1 
ENSMUST00000345499.1 ENSMUSG00000138095 ENSMUST00000345499.1 ENSMUSG00000138095 (from geneSymbol) uc337aam.1 uc337aam.1 
ENSMUST00000345500.1 1810049I09Rik ENSMUST00000345500.1 1810049I09Rik (from geneSymbol) AK007845 uc337aan.1 uc337aan.1 
ENSMUST00000345505.1 ENSMUSG00000138096 ENSMUST00000345505.1 ENSMUSG00000138096 (from geneSymbol) uc337aas.1 uc337aas.1 
ENSMUST00000345511.1 ENSMUSG00000138097 ENSMUST00000345511.1 ENSMUSG00000138097 (from geneSymbol) uc337aay.1 uc337aay.1 
ENSMUST00000345516.1 4930445N18Rik ENSMUST00000345516.1 4930445N18Rik (from geneSymbol) KY467816 uc337abd.1 uc337abd.1 
ENSMUST00000345540.1 ENSMUSG00000138098 ENSMUST00000345540.1 ENSMUSG00000138098 (from geneSymbol) AK139029 uc337acb.1 uc337acb.1 
ENSMUST00000345543.1 ENSMUSG00000138099 ENSMUST00000345543.1 ENSMUSG00000138099 (from geneSymbol) uc337ace.1 uc337ace.1 
ENSMUST00000345545.1 ENSMUSG00000138100 ENSMUST00000345545.1 ENSMUSG00000138100 (from geneSymbol) uc337acg.1 uc337acg.1 
ENSMUST00000345548.1 Gm32442 ENSMUST00000345548.1 Gm32442 (from geneSymbol) AK135963 uc337acj.1 uc337acj.1 
ENSMUST00000345559.1 ENSMUSG00000138101 ENSMUST00000345559.1 ENSMUSG00000138101 (from geneSymbol) uc337acu.1 uc337acu.1 
ENSMUST00000345563.1 ENSMUSG00000138102 ENSMUST00000345563.1 ENSMUSG00000138102 (from geneSymbol) uc337acy.1 uc337acy.1 
ENSMUST00000345565.1 ENSMUSG00000138103 ENSMUST00000345565.1 ENSMUSG00000138103 (from geneSymbol) uc337ada.1 uc337ada.1 
ENSMUST00000345566.1 ENSMUSG00000138104 ENSMUST00000345566.1 ENSMUSG00000138104 (from geneSymbol) uc337adb.1 uc337adb.1 
ENSMUST00000345567.1 ENSMUSG00000138105 ENSMUST00000345567.1 ENSMUSG00000138105 (from geneSymbol) uc337adc.1 uc337adc.1 
ENSMUST00000345568.1 ENSMUSG00000138106 ENSMUST00000345568.1 ENSMUSG00000138106 (from geneSymbol) uc337add.1 uc337add.1 
ENSMUST00000345575.1 Gm28548 ENSMUST00000345575.1 Gm28548 (from geneSymbol) AK033064 uc337adk.1 uc337adk.1 
ENSMUST00000345583.1 ENSMUSG00000138107 ENSMUST00000345583.1 ENSMUSG00000138107 (from geneSymbol) uc337ads.1 uc337ads.1 
ENSMUST00000345584.1 ENSMUSG00000138108 ENSMUST00000345584.1 ENSMUSG00000138108 (from geneSymbol) uc337adt.1 uc337adt.1 
ENSMUST00000345585.1 ENSMUSG00000138109 ENSMUST00000345585.1 ENSMUSG00000138109 (from geneSymbol) uc337adu.1 uc337adu.1 
ENSMUST00000345586.1 ENSMUSG00000138110 ENSMUST00000345586.1 ENSMUSG00000138110 (from geneSymbol) uc337adv.1 uc337adv.1 
ENSMUST00000345587.1 ENSMUSG00000138111 ENSMUST00000345587.1 ENSMUSG00000138111 (from geneSymbol) uc337adw.1 uc337adw.1 
ENSMUST00000345588.1 ENSMUSG00000138112 ENSMUST00000345588.1 ENSMUSG00000138112 (from geneSymbol) uc337adx.1 uc337adx.1 
ENSMUST00000345591.1 ENSMUSG00000138113 ENSMUST00000345591.1 ENSMUSG00000138113 (from geneSymbol) uc337aea.1 uc337aea.1 
ENSMUST00000345593.1 ENSMUSG00000138114 ENSMUST00000345593.1 ENSMUSG00000138114 (from geneSymbol) uc337aec.1 uc337aec.1 
ENSMUST00000345594.1 ENSMUSG00000138115 ENSMUST00000345594.1 ENSMUSG00000138115 (from geneSymbol) uc337aed.1 uc337aed.1 
ENSMUST00000345595.1 Gm20548 ENSMUST00000345595.1 Gm20548 (from geneSymbol) uc337aee.1 uc337aee.1 
ENSMUST00000345597.1 ENSMUSG00000138116 ENSMUST00000345597.1 ENSMUSG00000138116 (from geneSymbol) uc337aeg.1 uc337aeg.1 
ENSMUST00000345600.1 ENSMUSG00000138117 ENSMUST00000345600.1 ENSMUSG00000138117 (from geneSymbol) AK005685 uc337aej.1 uc337aej.1 
ENSMUST00000345602.1 ENSMUSG00000138118 ENSMUST00000345602.1 ENSMUSG00000138118 (from geneSymbol) uc337ael.1 uc337ael.1 
ENSMUST00000345603.1 ENSMUSG00000138119 ENSMUST00000345603.1 ENSMUSG00000138119 (from geneSymbol) uc337aem.1 uc337aem.1 
ENSMUST00000345604.1 ENSMUSG00000138120 ENSMUST00000345604.1 ENSMUSG00000138120 (from geneSymbol) uc337aen.1 uc337aen.1 
ENSMUST00000345605.1 ENSMUSG00000138121 ENSMUST00000345605.1 ENSMUSG00000138121 (from geneSymbol) uc337aeo.1 uc337aeo.1 
ENSMUST00000345606.1 ENSMUSG00000138122 ENSMUST00000345606.1 ENSMUSG00000138122 (from geneSymbol) uc337aep.1 uc337aep.1 
ENSMUST00000345607.1 ENSMUSG00000138123 ENSMUST00000345607.1 ENSMUSG00000138123 (from geneSymbol) uc337aeq.1 uc337aeq.1 
ENSMUST00000345612.1 ENSMUSG00000138124 ENSMUST00000345612.1 ENSMUSG00000138124 (from geneSymbol) uc337aeu.1 uc337aeu.1 
ENSMUST00000345613.1 ENSMUSG00000138125 ENSMUST00000345613.1 ENSMUSG00000138125 (from geneSymbol) uc337aev.1 uc337aev.1 
ENSMUST00000345616.1 Gm40263 ENSMUST00000345616.1 Gm40263 (from geneSymbol) AK006939 uc337aey.1 uc337aey.1 
ENSMUST00000345634.1 Gm16188 ENSMUST00000345634.1 Gm16188 (from geneSymbol) KY468030 uc337afq.1 uc337afq.1 
ENSMUST00000345637.1 Gm41271 ENSMUST00000345637.1 Gm41271 (from geneSymbol) uc337aft.1 uc337aft.1 
ENSMUST00000345641.1 ENSMUSG00000138127 ENSMUST00000345641.1 ENSMUSG00000138127 (from geneSymbol) uc337afv.1 uc337afv.1 
ENSMUST00000345644.1 ENSMUSG00000138128 ENSMUST00000345644.1 ENSMUSG00000138128 (from geneSymbol) uc337afy.1 uc337afy.1 
ENSMUST00000345648.1 ENSMUSG00000138129 ENSMUST00000345648.1 ENSMUSG00000138129 (from geneSymbol) uc337agc.1 uc337agc.1 
ENSMUST00000345649.1 ENSMUSG00000138130 ENSMUST00000345649.1 ENSMUSG00000138130 (from geneSymbol) uc337agd.1 uc337agd.1 
ENSMUST00000345651.1 ENSMUSG00000138131 ENSMUST00000345651.1 ENSMUSG00000138131 (from geneSymbol) uc337agf.1 uc337agf.1 
ENSMUST00000345653.1 ENSMUSG00000138133 ENSMUST00000345653.1 ENSMUSG00000138133 (from geneSymbol) uc337agg.1 uc337agg.1 
ENSMUST00000345660.1 ENSMUSG00000138134 ENSMUST00000345660.1 ENSMUSG00000138134 (from geneSymbol) uc337agn.1 uc337agn.1 
ENSMUST00000345662.1 ENSMUSG00000138135 ENSMUST00000345662.1 ENSMUSG00000138135 (from geneSymbol) uc337agp.1 uc337agp.1 
ENSMUST00000345677.1 ENSMUSG00000138136 ENSMUST00000345677.1 ENSMUSG00000138136 (from geneSymbol) uc337ahd.1 uc337ahd.1 
ENSMUST00000345705.1 ENSMUSG00000138137 ENSMUST00000345705.1 ENSMUSG00000138137 (from geneSymbol) uc337aif.1 uc337aif.1 
ENSMUST00000345711.1 ENSMUSG00000138138 ENSMUST00000345711.1 ENSMUSG00000138138 (from geneSymbol) uc337ail.1 uc337ail.1 
ENSMUST00000345712.1 ENSMUSG00000138139 ENSMUST00000345712.1 ENSMUSG00000138139 (from geneSymbol) uc337aim.1 uc337aim.1 
ENSMUST00000345713.1 ENSMUSG00000138140 ENSMUST00000345713.1 ENSMUSG00000138140 (from geneSymbol) uc337ain.1 uc337ain.1 
ENSMUST00000345714.1 ENSMUSG00000138141 ENSMUST00000345714.1 ENSMUSG00000138141 (from geneSymbol) uc337aio.1 uc337aio.1 
ENSMUST00000345716.1 Gm56749 ENSMUST00000345716.1 Gm56749 (from geneSymbol) uc337aiq.1 uc337aiq.1 
ENSMUST00000345736.1 ENSMUSG00000138142 ENSMUST00000345736.1 ENSMUSG00000138142 (from geneSymbol) AK015084 uc337ajk.1 uc337ajk.1 
ENSMUST00000345743.1 ENSMUSG00000138143 ENSMUST00000345743.1 ENSMUSG00000138143 (from geneSymbol) uc337ajr.1 uc337ajr.1 
ENSMUST00000345824.1 ENSMUSG00000138144 ENSMUST00000345824.1 ENSMUSG00000138144 (from geneSymbol) uc337amt.1 uc337amt.1 
ENSMUST00000345831.1 ENSMUSG00000138145 ENSMUST00000345831.1 ENSMUSG00000138145 (from geneSymbol) uc337ana.1 uc337ana.1 
ENSMUST00000345833.1 ENSMUSG00000138146 ENSMUST00000345833.1 ENSMUSG00000138146 (from geneSymbol) AK131806 uc337anc.1 uc337anc.1 
ENSMUST00000345834.1 4930412E21Rik ENSMUST00000345834.1 4930412E21Rik (from geneSymbol) AK015118 uc337and.1 uc337and.1 
ENSMUST00000345859.1 ENSMUSG00000138147 ENSMUST00000345859.1 ENSMUSG00000138147 (from geneSymbol) uc337aoc.1 uc337aoc.1 
ENSMUST00000345890.1 ENSMUSG00000138148 ENSMUST00000345890.1 ENSMUSG00000138148 (from geneSymbol) uc337aph.1 uc337aph.1 
ENSMUST00000345894.1 ENSMUSG00000138149 ENSMUST00000345894.1 ENSMUSG00000138149 (from geneSymbol) uc337apl.1 uc337apl.1 
ENSMUST00000345895.1 ENSMUSG00000138150 ENSMUST00000345895.1 ENSMUSG00000138150 (from geneSymbol) uc337apm.1 uc337apm.1 
ENSMUST00000345897.1 Gm10138 ENSMUST00000345897.1 Gm10138 (from geneSymbol) uc337apo.1 uc337apo.1 
ENSMUST00000345915.1 ENSMUSG00000138151 ENSMUST00000345915.1 ENSMUSG00000138151 (from geneSymbol) uc337aqg.1 uc337aqg.1 
ENSMUST00000345916.1 ENSMUSG00000138152 ENSMUST00000345916.1 ENSMUSG00000138152 (from geneSymbol) uc337aqh.1 uc337aqh.1 
ENSMUST00000345918.1 ENSMUSG00000138153 ENSMUST00000345918.1 ENSMUSG00000138153 (from geneSymbol) uc337aqj.1 uc337aqj.1 
ENSMUST00000345924.1 ENSMUSG00000138154 ENSMUST00000345924.1 ENSMUSG00000138154 (from geneSymbol) uc337aqp.1 uc337aqp.1 
ENSMUST00000345931.1 ENSMUSG00000138155 ENSMUST00000345931.1 ENSMUSG00000138155 (from geneSymbol) uc337aqw.1 uc337aqw.1 
ENSMUST00000345934.1 ENSMUSG00000138156 ENSMUST00000345934.1 ENSMUSG00000138156 (from geneSymbol) uc337aqz.1 uc337aqz.1 
ENSMUST00000345936.1 ENSMUSG00000138157 ENSMUST00000345936.1 ENSMUSG00000138157 (from geneSymbol) uc337arb.1 uc337arb.1 
ENSMUST00000345937.1 ENSMUSG00000138158 ENSMUST00000345937.1 ENSMUSG00000138158 (from geneSymbol) uc337arc.1 uc337arc.1 
ENSMUST00000345939.1 ENSMUSG00000138159 ENSMUST00000345939.1 ENSMUSG00000138159 (from geneSymbol) uc337are.1 uc337are.1 
ENSMUST00000345946.1 ENSMUSG00000138160 ENSMUST00000345946.1 ENSMUSG00000138160 (from geneSymbol) uc337arl.1 uc337arl.1 
ENSMUST00000345947.1 ENSMUSG00000138161 ENSMUST00000345947.1 ENSMUSG00000138161 (from geneSymbol) uc337arm.1 uc337arm.1 
ENSMUST00000345956.1 ENSMUSG00000138162 ENSMUST00000345956.1 ENSMUSG00000138162 (from geneSymbol) uc337arv.1 uc337arv.1 
ENSMUST00000345958.1 ENSMUSG00000138163 ENSMUST00000345958.1 ENSMUSG00000138163 (from geneSymbol) uc337arx.1 uc337arx.1 
ENSMUST00000345971.1 ENSMUSG00000138164 ENSMUST00000345971.1 ENSMUSG00000138164 (from geneSymbol) uc337ask.1 uc337ask.1 
ENSMUST00000345982.1 ENSMUSG00000138165 ENSMUST00000345982.1 ENSMUSG00000138165 (from geneSymbol) uc337asv.1 uc337asv.1 
ENSMUST00000345984.1 ENSMUSG00000138166 ENSMUST00000345984.1 ENSMUSG00000138166 (from geneSymbol) uc337asx.1 uc337asx.1 
ENSMUST00000345985.1 ENSMUSG00000138167 ENSMUST00000345985.1 ENSMUSG00000138167 (from geneSymbol) AK139414 uc337asy.1 uc337asy.1 
ENSMUST00000345986.1 2210408F21Rik ENSMUST00000345986.1 2210408F21Rik (from geneSymbol) BC099512 uc337asz.1 uc337asz.1 
ENSMUST00000346205.1 ENSMUSG00000138168 ENSMUST00000346205.1 ENSMUSG00000138168 (from geneSymbol) uc337bbe.1 uc337bbe.1 
ENSMUST00000346209.1 ENSMUSG00000138169 ENSMUST00000346209.1 ENSMUSG00000138169 (from geneSymbol) uc337bbi.1 uc337bbi.1 
ENSMUST00000346210.1 ENSMUSG00000138170 ENSMUST00000346210.1 ENSMUSG00000138170 (from geneSymbol) uc337bbj.1 uc337bbj.1 
ENSMUST00000346211.1 ENSMUSG00000138171 ENSMUST00000346211.1 ENSMUSG00000138171 (from geneSymbol) uc337bbk.1 uc337bbk.1 
ENSMUST00000346213.1 ENSMUSG00000138172 ENSMUST00000346213.1 ENSMUSG00000138172 (from geneSymbol) uc337bbm.1 uc337bbm.1 
ENSMUST00000346214.1 ENSMUSG00000138173 ENSMUST00000346214.1 ENSMUSG00000138173 (from geneSymbol) uc337bbn.1 uc337bbn.1 
ENSMUST00000346215.1 Gm49448 ENSMUST00000346215.1 Gm49448 (from geneSymbol) uc337bbo.1 uc337bbo.1 
ENSMUST00000346230.1 ENSMUSG00000138174 ENSMUST00000346230.1 ENSMUSG00000138174 (from geneSymbol) uc337bcd.1 uc337bcd.1 
ENSMUST00000346232.1 ENSMUSG00000138175 ENSMUST00000346232.1 ENSMUSG00000138175 (from geneSymbol) uc337bcf.1 uc337bcf.1 
ENSMUST00000346235.1 ENSMUSG00000138176 ENSMUST00000346235.1 ENSMUSG00000138176 (from geneSymbol) uc337bci.1 uc337bci.1 
ENSMUST00000346239.1 ENSMUSG00000138177 ENSMUST00000346239.1 ENSMUSG00000138177 (from geneSymbol) uc337bcm.1 uc337bcm.1 
ENSMUST00000346243.1 ENSMUSG00000138178 ENSMUST00000346243.1 ENSMUSG00000138178 (from geneSymbol) uc337bcq.1 uc337bcq.1 
ENSMUST00000346260.1 ENSMUSG00000138179 ENSMUST00000346260.1 ENSMUSG00000138179 (from geneSymbol) uc337bdh.1 uc337bdh.1 
ENSMUST00000346261.1 ENSMUSG00000138180 ENSMUST00000346261.1 ENSMUSG00000138180 (from geneSymbol) uc337bdi.1 uc337bdi.1 
ENSMUST00000346263.1 ENSMUSG00000138181 ENSMUST00000346263.1 ENSMUSG00000138181 (from geneSymbol) uc337bdk.1 uc337bdk.1 
ENSMUST00000346266.1 ENSMUSG00000138182 ENSMUST00000346266.1 ENSMUSG00000138182 (from geneSymbol) uc337bdn.1 uc337bdn.1 
ENSMUST00000346272.1 ENSMUSG00000138183 ENSMUST00000346272.1 ENSMUSG00000138183 (from geneSymbol) uc337bdt.1 uc337bdt.1 
ENSMUST00000346278.1 ENSMUSG00000138184 ENSMUST00000346278.1 ENSMUSG00000138184 (from geneSymbol) uc337bdz.1 uc337bdz.1 
ENSMUST00000346292.1 ENSMUSG00000138185 ENSMUST00000346292.1 ENSMUSG00000138185 (from geneSymbol) uc337ben.1 uc337ben.1 
ENSMUST00000346293.1 ENSMUSG00000138186 ENSMUST00000346293.1 ENSMUSG00000138186 (from geneSymbol) uc337beo.1 uc337beo.1 
ENSMUST00000346295.1 ENSMUSG00000138187 ENSMUST00000346295.1 ENSMUSG00000138187 (from geneSymbol) AK030037 uc337beq.1 uc337beq.1 
ENSMUST00000346301.1 ENSMUSG00000138188 ENSMUST00000346301.1 ENSMUSG00000138188 (from geneSymbol) DL243184 uc337bev.1 uc337bev.1 
ENSMUST00000346302.1 ENSMUSG00000138189 ENSMUST00000346302.1 ENSMUSG00000138189 (from geneSymbol) uc337bew.1 uc337bew.1 
ENSMUST00000346304.1 Gm28747 ENSMUST00000346304.1 Gm28747 (from geneSymbol) uc337bey.1 uc337bey.1 
ENSMUST00000346305.1 ENSMUSG00000138190 ENSMUST00000346305.1 ENSMUSG00000138190 (from geneSymbol) uc337bez.1 uc337bez.1 
ENSMUST00000346306.1 ENSMUSG00000138191 ENSMUST00000346306.1 ENSMUSG00000138191 (from geneSymbol) uc337bfa.1 uc337bfa.1 
ENSMUST00000346307.1 ENSMUSG00000138192 ENSMUST00000346307.1 ENSMUSG00000138192 (from geneSymbol) uc337bfb.1 uc337bfb.1 
ENSMUST00000346311.1 ENSMUSG00000138194 ENSMUST00000346311.1 ENSMUSG00000138194 (from geneSymbol) uc337bfe.1 uc337bfe.1 
ENSMUST00000346315.1 ENSMUSG00000138195 ENSMUST00000346315.1 ENSMUSG00000138195 (from geneSymbol) uc337bfi.1 uc337bfi.1 
ENSMUST00000346316.1 ENSMUSG00000138196 ENSMUST00000346316.1 ENSMUSG00000138196 (from geneSymbol) uc337bfj.1 uc337bfj.1 
ENSMUST00000346318.1 ENSMUSG00000138197 ENSMUST00000346318.1 ENSMUSG00000138197 (from geneSymbol) uc337bfl.1 uc337bfl.1 
ENSMUST00000346321.1 ENSMUSG00000138198 ENSMUST00000346321.1 ENSMUSG00000138198 (from geneSymbol) uc337bfo.1 uc337bfo.1 
ENSMUST00000346326.1 ENSMUSG00000138199 ENSMUST00000346326.1 ENSMUSG00000138199 (from geneSymbol) uc337bft.1 uc337bft.1 
ENSMUST00000346329.1 ENSMUSG00000138200 ENSMUST00000346329.1 ENSMUSG00000138200 (from geneSymbol) uc337bfw.1 uc337bfw.1 
ENSMUST00000346332.1 ENSMUSG00000138201 ENSMUST00000346332.1 ENSMUSG00000138201 (from geneSymbol) uc337bfz.1 uc337bfz.1 
ENSMUST00000346333.1 ENSMUSG00000138202 ENSMUST00000346333.1 ENSMUSG00000138202 (from geneSymbol) uc337bga.1 uc337bga.1 
ENSMUST00000346334.1 Gm13068 ENSMUST00000346334.1 Gm13068 (from geneSymbol) uc337bgb.1 uc337bgb.1 
ENSMUST00000346335.1 ENSMUSG00000138203 ENSMUST00000346335.1 ENSMUSG00000138203 (from geneSymbol) uc337bgc.1 uc337bgc.1 
ENSMUST00000346336.1 ENSMUSG00000138204 ENSMUST00000346336.1 ENSMUSG00000138204 (from geneSymbol) uc337bgd.1 uc337bgd.1 
ENSMUST00000346337.1 ENSMUSG00000138205 ENSMUST00000346337.1 ENSMUSG00000138205 (from geneSymbol) uc337bge.1 uc337bge.1 
ENSMUST00000346341.1 ENSMUSG00000138206 ENSMUST00000346341.1 ENSMUSG00000138206 (from geneSymbol) uc337bgi.1 uc337bgi.1 
ENSMUST00000346345.1 ENSMUSG00000138208 ENSMUST00000346345.1 ENSMUSG00000138208 (from geneSymbol) uc337bgj.1 uc337bgj.1 
ENSMUST00000346346.1 ENSMUSG00000138209 ENSMUST00000346346.1 ENSMUSG00000138209 (from geneSymbol) uc337bgk.1 uc337bgk.1 
ENSMUST00000346349.1 ENSMUSG00000138210 ENSMUST00000346349.1 ENSMUSG00000138210 (from geneSymbol) uc337bgn.1 uc337bgn.1 
ENSMUST00000346350.1 ENSMUSG00000138211 ENSMUST00000346350.1 ENSMUSG00000138211 (from geneSymbol) uc337bgo.1 uc337bgo.1 
ENSMUST00000346352.1 ENSMUSG00000138212 ENSMUST00000346352.1 ENSMUSG00000138212 (from geneSymbol) uc337bgq.1 uc337bgq.1 
ENSMUST00000346353.1 Gm8579 ENSMUST00000346353.1 Gm8579 (from geneSymbol) AK080102 uc337bgr.1 uc337bgr.1 
ENSMUST00000346366.1 Gm45494 ENSMUST00000346366.1 Gm45494 (from geneSymbol) uc337bhe.1 uc337bhe.1 
ENSMUST00000346367.1 ENSMUSG00000138213 ENSMUST00000346367.1 ENSMUSG00000138213 (from geneSymbol) uc337bhf.1 uc337bhf.1 
ENSMUST00000346368.1 ENSMUSG00000138214 ENSMUST00000346368.1 ENSMUSG00000138214 (from geneSymbol) uc337bhg.1 uc337bhg.1 
ENSMUST00000346370.1 Gm47336 ENSMUST00000346370.1 Gm47336 (from geneSymbol) uc337bhi.1 uc337bhi.1 
ENSMUST00000346372.1 ENSMUSG00000138215 ENSMUST00000346372.1 ENSMUSG00000138215 (from geneSymbol) uc337bhk.1 uc337bhk.1 
ENSMUST00000346375.1 ENSMUSG00000138216 ENSMUST00000346375.1 ENSMUSG00000138216 (from geneSymbol) uc337bhn.1 uc337bhn.1 
ENSMUST00000346376.1 ENSMUSG00000138217 ENSMUST00000346376.1 ENSMUSG00000138217 (from geneSymbol) uc337bho.1 uc337bho.1 
ENSMUST00000346377.1 ENSMUSG00000138218 ENSMUST00000346377.1 ENSMUSG00000138218 (from geneSymbol) uc337bhp.1 uc337bhp.1 
ENSMUST00000346382.1 ENSMUSG00000138219 ENSMUST00000346382.1 ENSMUSG00000138219 (from geneSymbol) uc337bhu.1 uc337bhu.1 
ENSMUST00000346383.1 ENSMUSG00000138220 ENSMUST00000346383.1 ENSMUSG00000138220 (from geneSymbol) uc337bhv.1 uc337bhv.1 
ENSMUST00000346384.1 ENSMUSG00000138221 ENSMUST00000346384.1 ENSMUSG00000138221 (from geneSymbol) uc337bhw.1 uc337bhw.1 
ENSMUST00000346387.1 ENSMUSG00000138223 ENSMUST00000346387.1 ENSMUSG00000138223 (from geneSymbol) uc337bhy.1 uc337bhy.1 
ENSMUST00000346391.1 Gm33326 ENSMUST00000346391.1 Gm33326 (from geneSymbol) AK143741 uc337bic.1 uc337bic.1 
ENSMUST00000346397.1 ENSMUSG00000138224 ENSMUST00000346397.1 ENSMUSG00000138224 (from geneSymbol) uc337bii.1 uc337bii.1 
ENSMUST00000346400.1 ENSMUSG00000138225 ENSMUST00000346400.1 ENSMUSG00000138225 (from geneSymbol) uc337bil.1 uc337bil.1 
ENSMUST00000346403.1 ENSMUSG00000138226 ENSMUST00000346403.1 ENSMUSG00000138226 (from geneSymbol) uc337bio.1 uc337bio.1 
ENSMUST00000346404.1 ENSMUSG00000138227 ENSMUST00000346404.1 ENSMUSG00000138227 (from geneSymbol) uc337bip.1 uc337bip.1 
ENSMUST00000346405.1 ENSMUSG00000138228 ENSMUST00000346405.1 ENSMUSG00000138228 (from geneSymbol) uc337biq.1 uc337biq.1 
ENSMUST00000346406.1 ENSMUSG00000138229 ENSMUST00000346406.1 ENSMUSG00000138229 (from geneSymbol) uc337bir.1 uc337bir.1 
ENSMUST00000346408.1 ENSMUSG00000138230 ENSMUST00000346408.1 ENSMUSG00000138230 (from geneSymbol) uc337bit.1 uc337bit.1 
ENSMUST00000346410.1 ENSMUSG00000138231 ENSMUST00000346410.1 ENSMUSG00000138231 (from geneSymbol) uc337biv.1 uc337biv.1 
ENSMUST00000346411.1 ENSMUSG00000138232 ENSMUST00000346411.1 ENSMUSG00000138232 (from geneSymbol) uc337biw.1 uc337biw.1 
ENSMUST00000346412.1 ENSMUSG00000138233 ENSMUST00000346412.1 ENSMUSG00000138233 (from geneSymbol) uc337bix.1 uc337bix.1 
ENSMUST00000346418.1 ENSMUSG00000138234 ENSMUST00000346418.1 ENSMUSG00000138234 (from geneSymbol) uc337bjd.1 uc337bjd.1 
ENSMUST00000346419.1 ENSMUSG00000138235 ENSMUST00000346419.1 ENSMUSG00000138235 (from geneSymbol) uc337bje.1 uc337bje.1 
ENSMUST00000346421.1 ENSMUSG00000138236 ENSMUST00000346421.1 ENSMUSG00000138236 (from geneSymbol) uc337bjg.1 uc337bjg.1 
ENSMUST00000346422.1 ENSMUSG00000138237 ENSMUST00000346422.1 ENSMUSG00000138237 (from geneSymbol) uc337bjh.1 uc337bjh.1 
ENSMUST00000346425.1 ENSMUSG00000138238 ENSMUST00000346425.1 ENSMUSG00000138238 (from geneSymbol) uc337bjk.1 uc337bjk.1 
ENSMUST00000346428.1 ENSMUSG00000138239 ENSMUST00000346428.1 ENSMUSG00000138239 (from geneSymbol) uc337bjn.1 uc337bjn.1 
ENSMUST00000346440.1 ENSMUSG00000138240 ENSMUST00000346440.1 ENSMUSG00000138240 (from geneSymbol) uc337bjz.1 uc337bjz.1 
ENSMUST00000346441.1 ENSMUSG00000138241 ENSMUST00000346441.1 ENSMUSG00000138241 (from geneSymbol) uc337bka.1 uc337bka.1 
ENSMUST00000346465.1 ENSMUSG00000138242 ENSMUST00000346465.1 ENSMUSG00000138242 (from geneSymbol) uc337bky.1 uc337bky.1 
ENSMUST00000346466.1 ENSMUSG00000138243 ENSMUST00000346466.1 ENSMUSG00000138243 (from geneSymbol) uc337bkz.1 uc337bkz.1 
ENSMUST00000346468.1 ENSMUSG00000138245 ENSMUST00000346468.1 ENSMUSG00000138245 (from geneSymbol) uc337bla.1 uc337bla.1 
ENSMUST00000346472.1 ENSMUSG00000138246 ENSMUST00000346472.1 ENSMUSG00000138246 (from geneSymbol) uc337ble.1 uc337ble.1 
ENSMUST00000346473.1 ENSMUSG00000138247 ENSMUST00000346473.1 ENSMUSG00000138247 (from geneSymbol) uc337blf.1 uc337blf.1 
ENSMUST00000346475.1 ENSMUSG00000138248 ENSMUST00000346475.1 ENSMUSG00000138248 (from geneSymbol) uc337blh.1 uc337blh.1 
ENSMUST00000346483.1 ENSMUSG00000138249 ENSMUST00000346483.1 ENSMUSG00000138249 (from geneSymbol) uc337blp.1 uc337blp.1 
ENSMUST00000346500.1 ENSMUSG00000138250 ENSMUST00000346500.1 ENSMUSG00000138250 (from geneSymbol) uc337bmg.1 uc337bmg.1 
ENSMUST00000346501.1 ENSMUSG00000138251 ENSMUST00000346501.1 ENSMUSG00000138251 (from geneSymbol) uc337bmh.1 uc337bmh.1 
ENSMUST00000346502.1 ENSMUSG00000138252 ENSMUST00000346502.1 ENSMUSG00000138252 (from geneSymbol) uc337bmi.1 uc337bmi.1 
ENSMUST00000346503.1 ENSMUSG00000138253 ENSMUST00000346503.1 ENSMUSG00000138253 (from geneSymbol) uc337bmj.1 uc337bmj.1 
ENSMUST00000346505.1 ENSMUSG00000138254 ENSMUST00000346505.1 ENSMUSG00000138254 (from geneSymbol) uc337bml.1 uc337bml.1 
ENSMUST00000346510.1 ENSMUSG00000138255 ENSMUST00000346510.1 ENSMUSG00000138255 (from geneSymbol) uc337bmq.1 uc337bmq.1 
ENSMUST00000346517.1 Gm19272 ENSMUST00000346517.1 Gm19272 (from geneSymbol) AK133014 uc337bmx.1 uc337bmx.1 
ENSMUST00000346544.1 Gm26787 ENSMUST00000346544.1 Gm26787 (from geneSymbol) AK018988 uc337bny.1 uc337bny.1 
ENSMUST00000346558.1 ENSMUSG00000138256 ENSMUST00000346558.1 ENSMUSG00000138256 (from geneSymbol) uc337bom.1 uc337bom.1 
ENSMUST00000346559.1 ENSMUSG00000138257 ENSMUST00000346559.1 ENSMUSG00000138257 (from geneSymbol) uc337bon.1 uc337bon.1 
ENSMUST00000346560.1 ENSMUSG00000138258 ENSMUST00000346560.1 ENSMUSG00000138258 (from geneSymbol) BC099537 uc337boo.1 uc337boo.1 
ENSMUST00000346570.1 ENSMUSG00000138259 ENSMUST00000346570.1 ENSMUSG00000138259 (from geneSymbol) uc337boy.1 uc337boy.1 
ENSMUST00000346584.1 ENSMUSG00000138260 ENSMUST00000346584.1 ENSMUSG00000138260 (from geneSymbol) uc337bpm.1 uc337bpm.1 
ENSMUST00000346595.1 ENSMUSG00000138261 ENSMUST00000346595.1 ENSMUSG00000138261 (from geneSymbol) uc337bpx.1 uc337bpx.1 
ENSMUST00000346598.1 ENSMUSG00000138262 ENSMUST00000346598.1 ENSMUSG00000138262 (from geneSymbol) BC150918 uc337bqa.1 uc337bqa.1 
ENSMUST00000346600.1 ENSMUSG00000138263 ENSMUST00000346600.1 ENSMUSG00000138263 (from geneSymbol) uc337bqc.1 uc337bqc.1 
ENSMUST00000346601.1 ENSMUSG00000138264 ENSMUST00000346601.1 ENSMUSG00000138264 (from geneSymbol) uc337bqd.1 uc337bqd.1 
ENSMUST00000346602.1 Gm17435 ENSMUST00000346602.1 Gm17435 (from geneSymbol) AK085371 uc337bqe.1 uc337bqe.1 
ENSMUST00000346610.1 ENSMUSG00000138266 ENSMUST00000346610.1 ENSMUSG00000138266 (from geneSymbol) uc337bql.1 uc337bql.1 
ENSMUST00000346612.1 ENSMUSG00000138267 ENSMUST00000346612.1 ENSMUSG00000138267 (from geneSymbol) uc337bqn.1 uc337bqn.1 
ENSMUST00000346645.1 ENSMUSG00000138268 ENSMUST00000346645.1 ENSMUSG00000138268 (from geneSymbol) uc337bru.1 uc337bru.1 
ENSMUST00000346660.1 Gm30969 ENSMUST00000346660.1 Gm30969 (from geneSymbol) uc337bsj.1 uc337bsj.1 
ENSMUST00000346662.1 ENSMUSG00000138269 ENSMUST00000346662.1 ENSMUSG00000138269 (from geneSymbol) uc337bsl.1 uc337bsl.1 
ENSMUST00000346663.1 ENSMUSG00000138270 ENSMUST00000346663.1 ENSMUSG00000138270 (from geneSymbol) uc337bsm.1 uc337bsm.1 
ENSMUST00000346667.1 ENSMUSG00000138271 ENSMUST00000346667.1 ENSMUSG00000138271 (from geneSymbol) uc337bsq.1 uc337bsq.1 
ENSMUST00000346678.1 Gm10646 ENSMUST00000346678.1 Gm10646 (from geneSymbol) AK037358 uc337bta.1 uc337bta.1 
ENSMUST00000346683.1 ENSMUSG00000138273 ENSMUST00000346683.1 ENSMUSG00000138273 (from geneSymbol) uc337btf.1 uc337btf.1 
ENSMUST00000346699.1 Gm56933 ENSMUST00000346699.1 Gm56933 (from geneSymbol) uc337btv.1 uc337btv.1 
ENSMUST00000346702.1 ENSMUSG00000138274 ENSMUST00000346702.1 ENSMUSG00000138274 (from geneSymbol) uc337bty.1 uc337bty.1 
ENSMUST00000346703.1 ENSMUSG00000138275 ENSMUST00000346703.1 ENSMUSG00000138275 (from geneSymbol) uc337btz.1 uc337btz.1 
ENSMUST00000346705.1 1700023G09Rik ENSMUST00000346705.1 1700023G09Rik (from geneSymbol) AK006277 uc337bub.1 uc337bub.1 
ENSMUST00000346748.1 ENSMUSG00000138276 ENSMUST00000346748.1 ENSMUSG00000138276 (from geneSymbol) uc337bvs.1 uc337bvs.1 
ENSMUST00000346751.1 ENSMUSG00000138277 ENSMUST00000346751.1 ENSMUSG00000138277 (from geneSymbol) uc337bvv.1 uc337bvv.1 
ENSMUST00000346754.1 ENSMUSG00000138278 ENSMUST00000346754.1 ENSMUSG00000138278 (from geneSymbol) uc337bvy.1 uc337bvy.1 
ENSMUST00000346755.1 ENSMUSG00000138279 ENSMUST00000346755.1 ENSMUSG00000138279 (from geneSymbol) uc337bvz.1 uc337bvz.1 
ENSMUST00000346758.1 3632454L22Rik ENSMUST00000346758.1 3632454L22Rik (from geneSymbol) AK038525 uc337bwc.1 uc337bwc.1 
ENSMUST00000346763.1 ENSMUSG00000138280 ENSMUST00000346763.1 ENSMUSG00000138280 (from geneSymbol) uc337bwh.1 uc337bwh.1 
ENSMUST00000346767.1 ENSMUSG00000138281 ENSMUST00000346767.1 ENSMUSG00000138281 (from geneSymbol) uc337bwl.1 uc337bwl.1 
ENSMUST00000346771.1 Mkln1os ENSMUST00000346771.1 Mkln1os (from geneSymbol) AK043851 uc337bwp.1 uc337bwp.1 
ENSMUST00000346783.1 ENSMUSG00000138282 ENSMUST00000346783.1 ENSMUSG00000138282 (from geneSymbol) uc337bxb.1 uc337bxb.1 
ENSMUST00000346785.1 ENSMUSG00000138283 ENSMUST00000346785.1 ENSMUSG00000138283 (from geneSymbol) uc337bxd.1 uc337bxd.1 
ENSMUST00000346786.1 C030034L19Rik ENSMUST00000346786.1 C030034L19Rik (from geneSymbol) AK039918 uc337bxe.1 uc337bxe.1 
ENSMUST00000346886.1 ENSMUSG00000138284 ENSMUST00000346886.1 ENSMUSG00000138284 (from geneSymbol) uc337cay.1 uc337cay.1 
ENSMUST00000346891.1 Gm30713 ENSMUST00000346891.1 Gm30713 (from geneSymbol) uc337cbd.1 uc337cbd.1 
ENSMUST00000346900.1 Gm56576 ENSMUST00000346900.1 Gm56576 (from geneSymbol) uc337cbm.1 uc337cbm.1 
ENSMUST00000346904.1 Snhg16 ENSMUST00000346904.1 Snhg16 (from geneSymbol) AK088915 uc337cbq.1 uc337cbq.1 
ENSMUST00000346909.1 ENSMUSG00000138285 ENSMUST00000346909.1 ENSMUSG00000138285 (from geneSymbol) uc337cbv.1 uc337cbv.1 
ENSMUST00000346911.1 ENSMUSG00000138286 ENSMUST00000346911.1 ENSMUSG00000138286 (from geneSymbol) uc337cbx.1 uc337cbx.1 
ENSMUST00000346912.1 ENSMUSG00000138287 ENSMUST00000346912.1 ENSMUSG00000138287 (from geneSymbol) uc337cby.1 uc337cby.1 
ENSMUST00000346914.1 ENSMUSG00000138288 ENSMUST00000346914.1 ENSMUSG00000138288 (from geneSymbol) uc337cca.1 uc337cca.1 
ENSMUST00000346917.1 ENSMUSG00000138289 ENSMUST00000346917.1 ENSMUSG00000138289 (from geneSymbol) uc337ccd.1 uc337ccd.1 
ENSMUST00000346918.1 ENSMUSG00000138290 ENSMUST00000346918.1 ENSMUSG00000138290 (from geneSymbol) uc337cce.1 uc337cce.1 
ENSMUST00000346921.1 ENSMUSG00000138291 ENSMUST00000346921.1 ENSMUSG00000138291 (from geneSymbol) uc337cch.1 uc337cch.1 
ENSMUST00000346993.1 G630030J09Rik ENSMUST00000346993.1 G630030J09Rik (from geneSymbol) AK133438 uc337cfb.1 uc337cfb.1 
ENSMUST00000347010.1 ENSMUSG00000138292 ENSMUST00000347010.1 ENSMUSG00000138292 (from geneSymbol) uc337cfs.1 uc337cfs.1 
ENSMUST00000347011.1 ENSMUSG00000138293 ENSMUST00000347011.1 ENSMUSG00000138293 (from geneSymbol) uc337cft.1 uc337cft.1 
ENSMUST00000347012.1 ENSMUSG00000138294 ENSMUST00000347012.1 ENSMUSG00000138294 (from geneSymbol) uc337cfu.1 uc337cfu.1 
ENSMUST00000347020.1 ENSMUSG00000138295 ENSMUST00000347020.1 ENSMUSG00000138295 (from geneSymbol) uc337cgc.1 uc337cgc.1 
ENSMUST00000347023.1 ENSMUSG00000138297 ENSMUST00000347023.1 ENSMUSG00000138297 (from geneSymbol) uc337cge.1 uc337cge.1 
ENSMUST00000347025.1 ENSMUSG00000138298 ENSMUST00000347025.1 ENSMUSG00000138298 (from geneSymbol) uc337cgg.1 uc337cgg.1 
ENSMUST00000347026.1 ENSMUSG00000138299 ENSMUST00000347026.1 ENSMUSG00000138299 (from geneSymbol) uc337cgh.1 uc337cgh.1 
ENSMUST00000347027.1 ENSMUSG00000138300 ENSMUST00000347027.1 ENSMUSG00000138300 (from geneSymbol) uc337cgi.1 uc337cgi.1 
ENSMUST00000347029.1 ENSMUSG00000138301 ENSMUST00000347029.1 ENSMUSG00000138301 (from geneSymbol) AK076848 uc337cgk.1 uc337cgk.1 
ENSMUST00000347037.1 ENSMUSG00000138302 ENSMUST00000347037.1 ENSMUSG00000138302 (from geneSymbol) uc337cgs.1 uc337cgs.1 
ENSMUST00000347043.1 ENSMUSG00000138303 ENSMUST00000347043.1 ENSMUSG00000138303 (from geneSymbol) uc337cgy.1 uc337cgy.1 
ENSMUST00000347044.1 ENSMUSG00000138304 ENSMUST00000347044.1 ENSMUSG00000138304 (from geneSymbol) uc337cgz.1 uc337cgz.1 
ENSMUST00000347046.1 ENSMUSG00000138306 ENSMUST00000347046.1 ENSMUSG00000138306 (from geneSymbol) uc337cha.1 uc337cha.1 
ENSMUST00000347047.1 ENSMUSG00000138307 ENSMUST00000347047.1 ENSMUSG00000138307 (from geneSymbol) uc337chb.1 uc337chb.1 
ENSMUST00000347050.1 ENSMUSG00000138308 ENSMUST00000347050.1 ENSMUSG00000138308 (from geneSymbol) uc337chd.1 uc337chd.1 
ENSMUST00000347051.1 ENSMUSG00000138309 ENSMUST00000347051.1 ENSMUSG00000138309 (from geneSymbol) uc337che.1 uc337che.1 
ENSMUST00000347055.1 Gm40528 ENSMUST00000347055.1 Gm40528 (from geneSymbol) uc337chi.1 uc337chi.1 
ENSMUST00000347057.1 ENSMUSG00000138310 ENSMUST00000347057.1 ENSMUSG00000138310 (from geneSymbol) uc337chk.1 uc337chk.1 
ENSMUST00000347058.1 ENSMUSG00000138311 ENSMUST00000347058.1 ENSMUSG00000138311 (from geneSymbol) uc337chl.1 uc337chl.1 
ENSMUST00000347061.1 4732419C18Rik ENSMUST00000347061.1 4732419C18Rik (from geneSymbol) AK076318 uc337cho.1 uc337cho.1 
ENSMUST00000347078.1 ENSMUSG00000138312 ENSMUST00000347078.1 ENSMUSG00000138312 (from geneSymbol) uc337cif.1 uc337cif.1 
ENSMUST00000347082.1 ENSMUSG00000138313 ENSMUST00000347082.1 ENSMUSG00000138313 (from geneSymbol) uc337cij.1 uc337cij.1 
ENSMUST00000347083.1 ENSMUSG00000138314 ENSMUST00000347083.1 ENSMUSG00000138314 (from geneSymbol) AK148387 uc337cik.1 uc337cik.1 
ENSMUST00000347088.1 Gm56682 ENSMUST00000347088.1 Gm56682 (from geneSymbol) uc337cip.1 uc337cip.1 
ENSMUST00000347091.1 ENSMUSG00000138315 ENSMUST00000347091.1 ENSMUSG00000138315 (from geneSymbol) uc337cis.1 uc337cis.1 
ENSMUST00000347092.1 ENSMUSG00000138316 ENSMUST00000347092.1 ENSMUSG00000138316 (from geneSymbol) uc337cit.1 uc337cit.1 
ENSMUST00000347094.1 ENSMUSG00000138317 ENSMUST00000347094.1 ENSMUSG00000138317 (from geneSymbol) uc337civ.1 uc337civ.1 
ENSMUST00000347095.1 ENSMUSG00000138318 ENSMUST00000347095.1 ENSMUSG00000138318 (from geneSymbol) uc337ciw.1 uc337ciw.1 
ENSMUST00000347097.1 Gm9017 ENSMUST00000347097.1 Gm9017 (from geneSymbol) uc337ciy.1 uc337ciy.1 
ENSMUST00000347107.1 ENSMUSG00000138319 ENSMUST00000347107.1 ENSMUSG00000138319 (from geneSymbol) uc337cji.1 uc337cji.1 
ENSMUST00000347109.1 ENSMUSG00000138320 ENSMUST00000347109.1 ENSMUSG00000138320 (from geneSymbol) uc337cjj.1 uc337cjj.1 
ENSMUST00000347115.1 ENSMUSG00000138321 ENSMUST00000347115.1 ENSMUSG00000138321 (from geneSymbol) uc337cjp.1 uc337cjp.1 
ENSMUST00000347116.1 ENSMUSG00000138322 ENSMUST00000347116.1 ENSMUSG00000138322 (from geneSymbol) uc337cjq.1 uc337cjq.1 
ENSMUST00000347117.1 ENSMUSG00000138323 ENSMUST00000347117.1 ENSMUSG00000138323 (from geneSymbol) uc337cjr.1 uc337cjr.1 
ENSMUST00000347118.1 ENSMUSG00000138324 ENSMUST00000347118.1 ENSMUSG00000138324 (from geneSymbol) uc337cjs.1 uc337cjs.1 
ENSMUST00000347119.1 ENSMUSG00000138325 ENSMUST00000347119.1 ENSMUSG00000138325 (from geneSymbol) uc337cjt.1 uc337cjt.1 
ENSMUST00000347120.1 ENSMUSG00000138326 ENSMUST00000347120.1 ENSMUSG00000138326 (from geneSymbol) uc337cju.1 uc337cju.1 
ENSMUST00000347122.1 ENSMUSG00000138327 ENSMUST00000347122.1 ENSMUSG00000138327 (from geneSymbol) uc337cjw.1 uc337cjw.1 
ENSMUST00000347130.1 ENSMUSG00000138328 ENSMUST00000347130.1 ENSMUSG00000138328 (from geneSymbol) uc337ckd.1 uc337ckd.1 
ENSMUST00000347131.1 ENSMUSG00000138329 ENSMUST00000347131.1 ENSMUSG00000138329 (from geneSymbol) uc337cke.1 uc337cke.1 
ENSMUST00000347135.1 Gm39662 ENSMUST00000347135.1 Gm39662 (from geneSymbol) uc337cki.1 uc337cki.1 
ENSMUST00000347142.1 ENSMUSG00000138330 ENSMUST00000347142.1 ENSMUSG00000138330 (from geneSymbol) uc337ckp.1 uc337ckp.1 
ENSMUST00000347146.1 ENSMUSG00000138331 ENSMUST00000347146.1 ENSMUSG00000138331 (from geneSymbol) uc337ckt.1 uc337ckt.1 
ENSMUST00000347149.1 ENSMUSG00000138332 ENSMUST00000347149.1 ENSMUSG00000138332 (from geneSymbol) uc337ckw.1 uc337ckw.1 
ENSMUST00000347150.1 ENSMUSG00000138333 ENSMUST00000347150.1 ENSMUSG00000138333 (from geneSymbol) LF196208 uc337ckx.1 uc337ckx.1 
ENSMUST00000347151.1 ENSMUSG00000138334 ENSMUST00000347151.1 ENSMUSG00000138334 (from geneSymbol) uc337cky.1 uc337cky.1 
ENSMUST00000347159.1 Gm56833 ENSMUST00000347159.1 Gm56833 (from geneSymbol) uc337clg.1 uc337clg.1 
ENSMUST00000347167.1 ENSMUSG00000138335 ENSMUST00000347167.1 ENSMUSG00000138335 (from geneSymbol) uc337clo.1 uc337clo.1 
ENSMUST00000347237.1 ENSMUSG00000138336 ENSMUST00000347237.1 ENSMUSG00000138336 (from geneSymbol) BC119562 uc337cof.1 uc337cof.1 
ENSMUST00000347239.1 ENSMUSG00000138337 ENSMUST00000347239.1 ENSMUSG00000138337 (from geneSymbol) uc337coh.1 uc337coh.1 
ENSMUST00000347242.1 ENSMUSG00000138338 ENSMUST00000347242.1 ENSMUSG00000138338 (from geneSymbol) uc337cok.1 uc337cok.1 
ENSMUST00000347243.1 ENSMUSG00000138339 ENSMUST00000347243.1 ENSMUSG00000138339 (from geneSymbol) LF200725 uc337col.1 uc337col.1 
ENSMUST00000347244.1 ENSMUSG00000138340 ENSMUST00000347244.1 ENSMUSG00000138340 (from geneSymbol) uc337com.1 uc337com.1 
ENSMUST00000347245.1 ENSMUSG00000138341 ENSMUST00000347245.1 ENSMUSG00000138341 (from geneSymbol) uc337con.1 uc337con.1 
ENSMUST00000347246.1 Gm12153 ENSMUST00000347246.1 Gm12153 (from geneSymbol) AK090039 uc337coo.1 uc337coo.1 
ENSMUST00000347258.1 ENSMUSG00000138342 ENSMUST00000347258.1 ENSMUSG00000138342 (from geneSymbol) uc337cpa.1 uc337cpa.1 
ENSMUST00000347260.1 ENSMUSG00000138343 ENSMUST00000347260.1 ENSMUSG00000138343 (from geneSymbol) uc337cpc.1 uc337cpc.1 
ENSMUST00000347264.1 Rhox11-ps2 ENSMUST00000347264.1 reproductive homeobox 11, pseudogene 2 (from RefSeq NR_164362.1) NR_164362 uc337cpg.1 uc337cpg.1 
ENSMUST00000347275.1 Gm30639 ENSMUST00000347275.1 Gm30639 (from geneSymbol) uc337cpr.1 uc337cpr.1 
ENSMUST00000347279.1 ENSMUSG00000138345 ENSMUST00000347279.1 ENSMUSG00000138345 (from geneSymbol) uc337cpv.1 uc337cpv.1 
ENSMUST00000347282.1 Gm48876 ENSMUST00000347282.1 Gm48876 (from geneSymbol) AK042309 uc337cpy.1 uc337cpy.1 
ENSMUST00000347283.1 ENSMUSG00000138346 ENSMUST00000347283.1 ENSMUSG00000138346 (from geneSymbol) uc337cpz.1 uc337cpz.1 
ENSMUST00000347284.1 Gm11630 ENSMUST00000347284.1 Gm11630 (from geneSymbol) uc337cqa.1 uc337cqa.1 
ENSMUST00000347287.1 ENSMUSG00000138347 ENSMUST00000347287.1 ENSMUSG00000138347 (from geneSymbol) uc337cqd.1 uc337cqd.1 
ENSMUST00000347288.1 ENSMUSG00000138348 ENSMUST00000347288.1 ENSMUSG00000138348 (from geneSymbol) uc337cqe.1 uc337cqe.1 
ENSMUST00000347290.1 ENSMUSG00000138349 ENSMUST00000347290.1 ENSMUSG00000138349 (from geneSymbol) uc337cqg.1 uc337cqg.1 
ENSMUST00000347292.1 ENSMUSG00000138350 ENSMUST00000347292.1 ENSMUSG00000138350 (from geneSymbol) uc337cqi.1 uc337cqi.1 
ENSMUST00000347303.1 ENSMUSG00000138351 ENSMUST00000347303.1 ENSMUSG00000138351 (from geneSymbol) uc337cqt.1 uc337cqt.1 
ENSMUST00000347304.1 ENSMUSG00000138352 ENSMUST00000347304.1 ENSMUSG00000138352 (from geneSymbol) uc337cqu.1 uc337cqu.1 
ENSMUST00000347306.1 ENSMUSG00000138353 ENSMUST00000347306.1 ENSMUSG00000138353 (from geneSymbol) uc337cqw.1 uc337cqw.1 
ENSMUST00000347308.1 ENSMUSG00000138354 ENSMUST00000347308.1 ENSMUSG00000138354 (from geneSymbol) uc337cqy.1 uc337cqy.1 
ENSMUST00000347309.1 ENSMUSG00000138355 ENSMUST00000347309.1 ENSMUSG00000138355 (from geneSymbol) uc337cqz.1 uc337cqz.1 
ENSMUST00000347316.1 Gm31739 ENSMUST00000347316.1 predicted gene, 31739 (from RefSeq NR_166109.1) NR_166109 uc337crg.1 uc337crg.1 
ENSMUST00000347323.1 ENSMUSG00000138356 ENSMUST00000347323.1 ENSMUSG00000138356 (from geneSymbol) uc337crn.1 uc337crn.1 
ENSMUST00000347324.1 ENSMUSG00000138357 ENSMUST00000347324.1 ENSMUSG00000138357 (from geneSymbol) uc337cro.1 uc337cro.1 
ENSMUST00000347325.1 ENSMUSG00000138358 ENSMUST00000347325.1 ENSMUSG00000138358 (from geneSymbol) uc337crp.1 uc337crp.1 
ENSMUST00000347330.1 ENSMUSG00000138360 ENSMUST00000347330.1 ENSMUSG00000138360 (from geneSymbol) uc337crt.1 uc337crt.1 
ENSMUST00000347335.1 ENSMUSG00000138361 ENSMUST00000347335.1 ENSMUSG00000138361 (from geneSymbol) uc337cry.1 uc337cry.1 
ENSMUST00000347336.1 Crnde ENSMUST00000347336.1 Crnde (from geneSymbol) AK017076 uc337crz.1 uc337crz.1 
ENSMUST00000347464.1 ENSMUSG00000138362 ENSMUST00000347464.1 ENSMUSG00000138362 (from geneSymbol) uc337cww.1 uc337cww.1 
ENSMUST00000347494.1 4930407G08Rik ENSMUST00000347494.1 4930407G08Rik (from geneSymbol) AK019571 uc337cya.1 uc337cya.1 
ENSMUST00000347500.1 ENSMUSG00000138363 ENSMUST00000347500.1 ENSMUSG00000138363 (from geneSymbol) uc337cyg.1 uc337cyg.1 
ENSMUST00000347501.1 ENSMUSG00000138364 ENSMUST00000347501.1 ENSMUSG00000138364 (from geneSymbol) uc337cyh.1 uc337cyh.1 
ENSMUST00000347514.1 ENSMUSG00000138366 ENSMUST00000347514.1 ENSMUSG00000138366 (from geneSymbol) uc337cyt.1 uc337cyt.1 
ENSMUST00000347516.1 ENSMUSG00000138367 ENSMUST00000347516.1 ENSMUSG00000138367 (from geneSymbol) uc337cyv.1 uc337cyv.1 
ENSMUST00000347517.1 ENSMUSG00000138368 ENSMUST00000347517.1 ENSMUSG00000138368 (from geneSymbol) uc337cyw.1 uc337cyw.1 
ENSMUST00000347519.1 ENSMUSG00000138369 ENSMUST00000347519.1 ENSMUSG00000138369 (from geneSymbol) uc337cyy.1 uc337cyy.1 
ENSMUST00000347526.1 ENSMUSG00000138370 ENSMUST00000347526.1 ENSMUSG00000138370 (from geneSymbol) uc337czf.1 uc337czf.1 
ENSMUST00000347530.1 ENSMUSG00000138371 ENSMUST00000347530.1 ENSMUSG00000138371 (from geneSymbol) uc337czj.1 uc337czj.1 
ENSMUST00000347532.1 ENSMUSG00000138372 ENSMUST00000347532.1 ENSMUSG00000138372 (from geneSymbol) uc337czl.1 uc337czl.1 
ENSMUST00000347547.1 ENSMUSG00000138373 ENSMUST00000347547.1 ENSMUSG00000138373 (from geneSymbol) uc337daa.1 uc337daa.1 
ENSMUST00000347550.1 ENSMUSG00000138374 ENSMUST00000347550.1 ENSMUSG00000138374 (from geneSymbol) uc337dad.1 uc337dad.1 
ENSMUST00000347552.1 ENSMUSG00000138375 ENSMUST00000347552.1 ENSMUSG00000138375 (from geneSymbol) uc337daf.1 uc337daf.1 
ENSMUST00000347554.1 ENSMUSG00000138376 ENSMUST00000347554.1 ENSMUSG00000138376 (from geneSymbol) uc337dah.1 uc337dah.1 
ENSMUST00000347555.1 ENSMUSG00000138377 ENSMUST00000347555.1 ENSMUSG00000138377 (from geneSymbol) uc337dai.1 uc337dai.1 
ENSMUST00000347556.1 ENSMUSG00000138378 ENSMUST00000347556.1 ENSMUSG00000138378 (from geneSymbol) uc337daj.1 uc337daj.1 
ENSMUST00000347558.1 ENSMUSG00000138379 ENSMUST00000347558.1 ENSMUSG00000138379 (from geneSymbol) uc337dal.1 uc337dal.1 
ENSMUST00000347561.1 ENSMUSG00000138380 ENSMUST00000347561.1 ENSMUSG00000138380 (from geneSymbol) uc337dao.1 uc337dao.1 
ENSMUST00000347562.1 Gm16341 ENSMUST00000347562.1 Gm16341 (from geneSymbol) KY467497 uc337dap.1 uc337dap.1 
ENSMUST00000347575.1 ENSMUSG00000138381 ENSMUST00000347575.1 ENSMUSG00000138381 (from geneSymbol) uc337dbc.1 uc337dbc.1 
ENSMUST00000347576.1 ENSMUSG00000138382 ENSMUST00000347576.1 ENSMUSG00000138382 (from geneSymbol) uc337dbd.1 uc337dbd.1 
ENSMUST00000347577.1 ENSMUSG00000138383 ENSMUST00000347577.1 ENSMUSG00000138383 (from geneSymbol) uc337dbe.1 uc337dbe.1 
ENSMUST00000347589.1 4930505K13Rik ENSMUST00000347589.1 4930505K13Rik (from geneSymbol) AK015704 uc337dbq.1 uc337dbq.1 
ENSMUST00000347592.1 ENSMUSG00000138384 ENSMUST00000347592.1 ENSMUSG00000138384 (from geneSymbol) uc337dbt.1 uc337dbt.1 
ENSMUST00000347593.1 BC050972 ENSMUST00000347593.1 BC050972 (from geneSymbol) uc337dbu.1 uc337dbu.1 
ENSMUST00000347610.1 ENSMUSG00000138385 ENSMUST00000347610.1 ENSMUSG00000138385 (from geneSymbol) uc337dcl.1 uc337dcl.1 
ENSMUST00000347615.1 ENSMUSG00000138386 ENSMUST00000347615.1 ENSMUSG00000138386 (from geneSymbol) uc337dcq.1 uc337dcq.1 
ENSMUST00000347616.1 ENSMUSG00000138387 ENSMUST00000347616.1 ENSMUSG00000138387 (from geneSymbol) uc337dcr.1 uc337dcr.1 
ENSMUST00000347619.1 ENSMUSG00000138388 ENSMUST00000347619.1 ENSMUSG00000138388 (from geneSymbol) uc337dcu.1 uc337dcu.1 
ENSMUST00000347625.1 ENSMUSG00000138389 ENSMUST00000347625.1 ENSMUSG00000138389 (from geneSymbol) uc337dda.1 uc337dda.1 
ENSMUST00000347626.1 ENSMUSG00000138390 ENSMUST00000347626.1 ENSMUSG00000138390 (from geneSymbol) uc337ddb.1 uc337ddb.1 
ENSMUST00000347631.1 ENSMUSG00000138391 ENSMUST00000347631.1 ENSMUSG00000138391 (from geneSymbol) BC108389 uc337ddf.1 uc337ddf.1 
ENSMUST00000347633.1 4930539J05Rik ENSMUST00000347633.1 4930539J05Rik (from geneSymbol) uc337ddh.1 uc337ddh.1 
ENSMUST00000347660.1 ENSMUSG00000138392 ENSMUST00000347660.1 ENSMUSG00000138392 (from geneSymbol) uc337dei.1 uc337dei.1 
ENSMUST00000347663.1 ENSMUSG00000138393 ENSMUST00000347663.1 ENSMUSG00000138393 (from geneSymbol) uc337del.1 uc337del.1 
ENSMUST00000347664.1 Gm56919 ENSMUST00000347664.1 Gm56919 (from geneSymbol) uc337dem.1 uc337dem.1 
ENSMUST00000347669.1 ENSMUSG00000138394 ENSMUST00000347669.1 ENSMUSG00000138394 (from geneSymbol) uc337der.1 uc337der.1 
ENSMUST00000347670.1 ENSMUSG00000138395 ENSMUST00000347670.1 ENSMUSG00000138395 (from geneSymbol) uc337des.1 uc337des.1 
ENSMUST00000347673.1 ENSMUSG00000138396 ENSMUST00000347673.1 ENSMUSG00000138396 (from geneSymbol) uc337dev.1 uc337dev.1 
ENSMUST00000347676.1 ENSMUSG00000138397 ENSMUST00000347676.1 ENSMUSG00000138397 (from geneSymbol) uc337dey.1 uc337dey.1 
ENSMUST00000347682.1 ENSMUSG00000138398 ENSMUST00000347682.1 ENSMUSG00000138398 (from geneSymbol) uc337dfe.1 uc337dfe.1 
ENSMUST00000347683.1 ENSMUSG00000138399 ENSMUST00000347683.1 ENSMUSG00000138399 (from geneSymbol) DQ694443 uc337dff.1 uc337dff.1 
ENSMUST00000347684.1 ENSMUSG00000138400 ENSMUST00000347684.1 ENSMUSG00000138400 (from geneSymbol) uc337dfg.1 uc337dfg.1 
ENSMUST00000347685.1 ENSMUSG00000138401 ENSMUST00000347685.1 ENSMUSG00000138401 (from geneSymbol) LF201660 uc337dfh.1 uc337dfh.1 
ENSMUST00000347686.1 ENSMUSG00000138402 ENSMUST00000347686.1 ENSMUSG00000138402 (from geneSymbol) uc337dfi.1 uc337dfi.1 
ENSMUST00000347693.1 ENSMUSG00000138403 ENSMUST00000347693.1 ENSMUSG00000138403 (from geneSymbol) uc337dfp.1 uc337dfp.1 
ENSMUST00000347709.1 Gm12589 ENSMUST00000347709.1 Gm12589 (from geneSymbol) AK079017 uc337dgf.1 uc337dgf.1 
ENSMUST00000347717.1 ENSMUSG00000138404 ENSMUST00000347717.1 ENSMUSG00000138404 (from geneSymbol) uc337dgn.1 uc337dgn.1 
ENSMUST00000347726.1 ENSMUSG00000138406 ENSMUST00000347726.1 ENSMUSG00000138406 (from geneSymbol) uc337dgv.1 uc337dgv.1 
ENSMUST00000347729.1 ENSMUSG00000138407 ENSMUST00000347729.1 ENSMUSG00000138407 (from geneSymbol) uc337dgy.1 uc337dgy.1 
ENSMUST00000347730.1 ENSMUSG00000138408 ENSMUST00000347730.1 ENSMUSG00000138408 (from geneSymbol) uc337dgz.1 uc337dgz.1 
ENSMUST00000347731.1 ENSMUSG00000138409 ENSMUST00000347731.1 ENSMUSG00000138409 (from geneSymbol) uc337dha.1 uc337dha.1 
ENSMUST00000347732.1 ENSMUSG00000138410 ENSMUST00000347732.1 ENSMUSG00000138410 (from geneSymbol) uc337dhb.1 uc337dhb.1 
ENSMUST00000347733.1 ENSMUSG00000138411 ENSMUST00000347733.1 ENSMUSG00000138411 (from geneSymbol) uc337dhc.1 uc337dhc.1 
ENSMUST00000347741.1 Gm11655 ENSMUST00000347741.1 Gm11655 (from geneSymbol) KY467615 uc337dhk.1 uc337dhk.1 
ENSMUST00000347742.1 ENSMUSG00000138412 ENSMUST00000347742.1 ENSMUSG00000138412 (from geneSymbol) uc337dhl.1 uc337dhl.1 
ENSMUST00000347743.1 ENSMUSG00000138413 ENSMUST00000347743.1 ENSMUSG00000138413 (from geneSymbol) LF198947 uc337dhm.1 uc337dhm.1 
ENSMUST00000347744.1 ENSMUSG00000138414 ENSMUST00000347744.1 ENSMUSG00000138414 (from geneSymbol) LF202840 uc337dhn.1 uc337dhn.1 
ENSMUST00000347747.1 ENSMUSG00000138415 ENSMUST00000347747.1 ENSMUSG00000138415 (from geneSymbol) uc337dhq.1 uc337dhq.1 
ENSMUST00000347748.1 ENSMUSG00000138416 ENSMUST00000347748.1 ENSMUSG00000138416 (from geneSymbol) uc337dhr.1 uc337dhr.1 
ENSMUST00000347749.1 ENSMUSG00000138417 ENSMUST00000347749.1 ENSMUSG00000138417 (from geneSymbol) uc337dhs.1 uc337dhs.1 
ENSMUST00000347750.1 ENSMUSG00000138418 ENSMUST00000347750.1 ENSMUSG00000138418 (from geneSymbol) uc337dht.1 uc337dht.1 
ENSMUST00000347751.1 ENSMUSG00000138419 ENSMUST00000347751.1 ENSMUSG00000138419 (from geneSymbol) uc337dhu.1 uc337dhu.1 
ENSMUST00000347753.1 ENSMUSG00000138420 ENSMUST00000347753.1 ENSMUSG00000138420 (from geneSymbol) uc337dhw.1 uc337dhw.1 
ENSMUST00000347761.1 ENSMUSG00000138422 ENSMUST00000347761.1 ENSMUSG00000138422 (from geneSymbol) uc337did.1 uc337did.1 
ENSMUST00000347762.1 ENSMUSG00000138423 ENSMUST00000347762.1 ENSMUSG00000138423 (from geneSymbol) uc337die.1 uc337die.1 
ENSMUST00000347765.1 A630023P12Rik ENSMUST00000347765.1 A630023P12Rik (from geneSymbol) AK041600 uc337dih.1 uc337dih.1 
ENSMUST00000347796.1 ENSMUSG00000138424 ENSMUST00000347796.1 ENSMUSG00000138424 (from geneSymbol) uc337djm.1 uc337djm.1 
ENSMUST00000347798.1 ENSMUSG00000138425 ENSMUST00000347798.1 ENSMUSG00000138425 (from geneSymbol) uc337djo.1 uc337djo.1 
ENSMUST00000347807.1 ENSMUSG00000138426 ENSMUST00000347807.1 ENSMUSG00000138426 (from geneSymbol) uc337djx.1 uc337djx.1 
ENSMUST00000347810.1 ENSMUSG00000138427 ENSMUST00000347810.1 ENSMUSG00000138427 (from geneSymbol) uc337dka.1 uc337dka.1 
ENSMUST00000347816.1 ENSMUSG00000138428 ENSMUST00000347816.1 ENSMUSG00000138428 (from geneSymbol) uc337dkg.1 uc337dkg.1 
ENSMUST00000347819.1 Gm47507 ENSMUST00000347819.1 Gm47507 (from geneSymbol) uc337dkj.1 uc337dkj.1 
ENSMUST00000347842.1 ENSMUSG00000138429 ENSMUST00000347842.1 ENSMUSG00000138429 (from geneSymbol) uc337dlg.1 uc337dlg.1 
ENSMUST00000347843.1 ENSMUSG00000138430 ENSMUST00000347843.1 ENSMUSG00000138430 (from geneSymbol) uc337dlh.1 uc337dlh.1 
ENSMUST00000347844.1 ENSMUSG00000138431 ENSMUST00000347844.1 ENSMUSG00000138431 (from geneSymbol) uc337dli.1 uc337dli.1 
ENSMUST00000347845.1 ENSMUSG00000138432 ENSMUST00000347845.1 ENSMUSG00000138432 (from geneSymbol) uc337dlj.1 uc337dlj.1 
ENSMUST00000347847.1 ENSMUSG00000138433 ENSMUST00000347847.1 ENSMUSG00000138433 (from geneSymbol) uc337dll.1 uc337dll.1 
ENSMUST00000347849.1 ENSMUSG00000138434 ENSMUST00000347849.1 ENSMUSG00000138434 (from geneSymbol) uc337dln.1 uc337dln.1 
ENSMUST00000347853.1 ENSMUSG00000138435 ENSMUST00000347853.1 ENSMUSG00000138435 (from geneSymbol) uc337dlr.1 uc337dlr.1 
ENSMUST00000347863.1 ENSMUSG00000138436 ENSMUST00000347863.1 ENSMUSG00000138436 (from geneSymbol) uc337dmb.1 uc337dmb.1 
ENSMUST00000347867.1 ENSMUSG00000138437 ENSMUST00000347867.1 ENSMUSG00000138437 (from geneSymbol) uc337dmf.1 uc337dmf.1 
ENSMUST00000347868.1 Gm36033 ENSMUST00000347868.1 Gm36033 (from geneSymbol) uc337dmg.1 uc337dmg.1 
ENSMUST00000347881.1 ENSMUSG00000138438 ENSMUST00000347881.1 ENSMUSG00000138438 (from geneSymbol) uc337dmt.1 uc337dmt.1 
ENSMUST00000347885.1 4930594O21Rik ENSMUST00000347885.1 4930594O21Rik (from geneSymbol) AK016393 uc337dmx.1 uc337dmx.1 
ENSMUST00000347898.1 ENSMUSG00000138439 ENSMUST00000347898.1 ENSMUSG00000138439 (from geneSymbol) uc337dnj.1 uc337dnj.1 
ENSMUST00000347901.1 Gm49801 ENSMUST00000347901.1 Gm49801 (from geneSymbol) uc337dnm.1 uc337dnm.1 
ENSMUST00000347902.1 ENSMUSG00000138440 ENSMUST00000347902.1 ENSMUSG00000138440 (from geneSymbol) uc337dnn.1 uc337dnn.1 
ENSMUST00000347904.1 ENSMUSG00000138441 ENSMUST00000347904.1 ENSMUSG00000138441 (from geneSymbol) uc337dnp.1 uc337dnp.1 
ENSMUST00000347918.1 ENSMUSG00000138442 ENSMUST00000347918.1 ENSMUSG00000138442 (from geneSymbol) uc337dod.1 uc337dod.1 
ENSMUST00000347919.1 ENSMUSG00000138443 ENSMUST00000347919.1 ENSMUSG00000138443 (from geneSymbol) uc337doe.1 uc337doe.1 
ENSMUST00000347920.1 Gm45052 ENSMUST00000347920.1 Gm45052 (from geneSymbol) uc337dof.1 uc337dof.1 
ENSMUST00000347924.1 ENSMUSG00000138444 ENSMUST00000347924.1 ENSMUSG00000138444 (from geneSymbol) uc337doj.1 uc337doj.1 
ENSMUST00000347925.1 ENSMUSG00000138445 ENSMUST00000347925.1 ENSMUSG00000138445 (from geneSymbol) uc337dok.1 uc337dok.1 
ENSMUST00000347926.1 ENSMUSG00000138446 ENSMUST00000347926.1 ENSMUSG00000138446 (from geneSymbol) uc337dol.1 uc337dol.1 
ENSMUST00000347927.1 ENSMUSG00000138447 ENSMUST00000347927.1 ENSMUSG00000138447 (from geneSymbol) uc337dom.1 uc337dom.1 
ENSMUST00000347928.1 ENSMUSG00000138448 ENSMUST00000347928.1 ENSMUSG00000138448 (from geneSymbol) uc337don.1 uc337don.1 
ENSMUST00000347929.1 Gm56726 ENSMUST00000347929.1 Gm56726 (from geneSymbol) uc337doo.1 uc337doo.1 
ENSMUST00000347939.1 ENSMUSG00000138449 ENSMUST00000347939.1 ENSMUSG00000138449 (from geneSymbol) AK146411 uc337doy.1 uc337doy.1 
ENSMUST00000347943.1 ENSMUSG00000138450 ENSMUST00000347943.1 ENSMUSG00000138450 (from geneSymbol) uc337dpc.1 uc337dpc.1 
ENSMUST00000347945.1 ENSMUSG00000138451 ENSMUST00000347945.1 ENSMUSG00000138451 (from geneSymbol) uc337dpe.1 uc337dpe.1 
ENSMUST00000347947.1 ENSMUSG00000138452 ENSMUST00000347947.1 ENSMUSG00000138452 (from geneSymbol) uc337dpg.1 uc337dpg.1 
ENSMUST00000347951.1 3110039M20Rik ENSMUST00000347951.1 3110039M20Rik (from geneSymbol) AK043991 uc337dph.1 uc337dph.1 
ENSMUST00000347959.1 ENSMUSG00000138453 ENSMUST00000347959.1 ENSMUSG00000138453 (from geneSymbol) uc337dpp.1 uc337dpp.1 
ENSMUST00000347960.1 ENSMUSG00000138454 ENSMUST00000347960.1 ENSMUSG00000138454 (from geneSymbol) uc337dpq.1 uc337dpq.1 
ENSMUST00000347961.1 ENSMUSG00000138455 ENSMUST00000347961.1 ENSMUSG00000138455 (from geneSymbol) uc337dpr.1 uc337dpr.1 
ENSMUST00000347963.1 Gm36252 ENSMUST00000347963.1 Gm36252 (from geneSymbol) uc337dpt.1 uc337dpt.1 
ENSMUST00000347971.1 ENSMUSG00000138456 ENSMUST00000347971.1 ENSMUSG00000138456 (from geneSymbol) uc337dqb.1 uc337dqb.1 
ENSMUST00000347972.1 ENSMUSG00000138457 ENSMUST00000347972.1 ENSMUSG00000138457 (from geneSymbol) uc337dqc.1 uc337dqc.1 
ENSMUST00000347973.1 ENSMUSG00000138458 ENSMUST00000347973.1 ENSMUSG00000138458 (from geneSymbol) uc337dqd.1 uc337dqd.1 
ENSMUST00000347975.1 ENSMUSG00000138459 ENSMUST00000347975.1 ENSMUSG00000138459 (from geneSymbol) uc337dqf.1 uc337dqf.1 
ENSMUST00000347977.1 ENSMUSG00000138460 ENSMUST00000347977.1 ENSMUSG00000138460 (from geneSymbol) uc337dqh.1 uc337dqh.1 
ENSMUST00000347978.1 ENSMUSG00000138461 ENSMUST00000347978.1 ENSMUSG00000138461 (from geneSymbol) LF194690 uc337dqi.1 uc337dqi.1 
ENSMUST00000347980.1 Plet1os ENSMUST00000347980.1 Plet1os (from geneSymbol) AK009336 uc337dqk.1 uc337dqk.1 
ENSMUST00000347988.1 ENSMUSG00000138462 ENSMUST00000347988.1 ENSMUSG00000138462 (from geneSymbol) LF304461 uc337dqs.1 uc337dqs.1 
ENSMUST00000347989.1 ENSMUSG00000138463 ENSMUST00000347989.1 ENSMUSG00000138463 (from geneSymbol) uc337dqt.1 uc337dqt.1 
ENSMUST00000347990.1 ENSMUSG00000138464 ENSMUST00000347990.1 ENSMUSG00000138464 (from geneSymbol) uc337dqu.1 uc337dqu.1 
ENSMUST00000347992.1 ENSMUSG00000138465 ENSMUST00000347992.1 ENSMUSG00000138465 (from geneSymbol) uc337dqw.1 uc337dqw.1 
ENSMUST00000347993.1 ENSMUSG00000138466 ENSMUST00000347993.1 ENSMUSG00000138466 (from geneSymbol) uc337dqx.1 uc337dqx.1 
ENSMUST00000347994.1 ENSMUSG00000138467 ENSMUST00000347994.1 ENSMUSG00000138467 (from geneSymbol) uc337dqy.1 uc337dqy.1 
ENSMUST00000347995.1 ENSMUSG00000138468 ENSMUST00000347995.1 ENSMUSG00000138468 (from geneSymbol) uc337dqz.1 uc337dqz.1 
ENSMUST00000348014.1 ENSMUSG00000138469 ENSMUST00000348014.1 ENSMUSG00000138469 (from geneSymbol) uc337drs.1 uc337drs.1 
ENSMUST00000348016.1 ENSMUSG00000138470 ENSMUST00000348016.1 ENSMUSG00000138470 (from geneSymbol) uc337dru.1 uc337dru.1 
ENSMUST00000348021.1 ENSMUSG00000138471 ENSMUST00000348021.1 ENSMUSG00000138471 (from geneSymbol) AK029980 uc337drz.1 uc337drz.1 
ENSMUST00000348022.1 ENSMUSG00000138472 ENSMUST00000348022.1 ENSMUSG00000138472 (from geneSymbol) uc337dsa.1 uc337dsa.1 
ENSMUST00000348024.1 4921525O09Rik ENSMUST00000348024.1 4921525O09Rik (from geneSymbol) AK014969 uc337dsc.1 uc337dsc.1 
ENSMUST00000348027.1 1700018A04Rik ENSMUST00000348027.1 1700018A04Rik (from geneSymbol) AK006076 uc337dsf.1 uc337dsf.1 
ENSMUST00000348092.1 ENSMUSG00000138473 ENSMUST00000348092.1 ENSMUSG00000138473 (from geneSymbol) uc337dus.1 uc337dus.1 
ENSMUST00000348094.1 ENSMUSG00000138474 ENSMUST00000348094.1 ENSMUSG00000138474 (from geneSymbol) uc337duu.1 uc337duu.1 
ENSMUST00000348097.1 ENSMUSG00000138475 ENSMUST00000348097.1 ENSMUSG00000138475 (from geneSymbol) uc337dux.1 uc337dux.1 
ENSMUST00000348107.1 Gm15327 ENSMUST00000348107.1 Gm15327 (from geneSymbol) KY467682 uc337dvh.1 uc337dvh.1 
ENSMUST00000348117.1 ENSMUSG00000138476 ENSMUST00000348117.1 ENSMUSG00000138476 (from geneSymbol) uc337dvr.1 uc337dvr.1 
ENSMUST00000348118.1 ENSMUSG00000138477 ENSMUST00000348118.1 ENSMUSG00000138477 (from geneSymbol) uc337dvs.1 uc337dvs.1 
ENSMUST00000348119.1 ENSMUSG00000138478 ENSMUST00000348119.1 ENSMUSG00000138478 (from geneSymbol) uc337dvt.1 uc337dvt.1 
ENSMUST00000348120.1 ENSMUSG00000138479 ENSMUST00000348120.1 ENSMUSG00000138479 (from geneSymbol) uc337dvu.1 uc337dvu.1 
ENSMUST00000348121.1 ENSMUSG00000138480 ENSMUST00000348121.1 ENSMUSG00000138480 (from geneSymbol) uc337dvv.1 uc337dvv.1 
ENSMUST00000348122.1 ENSMUSG00000138481 ENSMUST00000348122.1 ENSMUSG00000138481 (from geneSymbol) uc337dvw.1 uc337dvw.1 
ENSMUST00000348123.1 ENSMUSG00000138482 ENSMUST00000348123.1 ENSMUSG00000138482 (from geneSymbol) uc337dvx.1 uc337dvx.1 
ENSMUST00000348125.1 ENSMUSG00000138483 ENSMUST00000348125.1 ENSMUSG00000138483 (from geneSymbol) uc337dvz.1 uc337dvz.1 
ENSMUST00000348129.1 Gm10685 ENSMUST00000348129.1 Gm10685 (from geneSymbol) uc337dwd.1 uc337dwd.1 
ENSMUST00000348133.1 ENSMUSG00000138484 ENSMUST00000348133.1 ENSMUSG00000138484 (from geneSymbol) uc337dwh.1 uc337dwh.1 
ENSMUST00000348134.1 Gm13629 ENSMUST00000348134.1 Gm13629 (from geneSymbol) AK138511 uc337dwi.1 uc337dwi.1 
ENSMUST00000348153.1 Gm15643 ENSMUST00000348153.1 Gm15643 (from geneSymbol) uc337dxb.1 uc337dxb.1 
ENSMUST00000348154.1 ENSMUSG00000138485 ENSMUST00000348154.1 ENSMUSG00000138485 (from geneSymbol) uc337dxc.1 uc337dxc.1 
ENSMUST00000348159.1 ENSMUSG00000138486 ENSMUST00000348159.1 ENSMUSG00000138486 (from geneSymbol) uc337dxh.1 uc337dxh.1 
ENSMUST00000348161.1 Gm9530 ENSMUST00000348161.1 Gm9530 (from geneSymbol) AK029591 uc337dxj.1 uc337dxj.1 
ENSMUST00000348170.1 Gm11290 ENSMUST00000348170.1 Gm11290 (from geneSymbol) AK040470 uc337dxs.1 uc337dxs.1 
ENSMUST00000348173.1 ENSMUSG00000138487 ENSMUST00000348173.1 ENSMUSG00000138487 (from geneSymbol) uc337dxv.1 uc337dxv.1 
ENSMUST00000348174.1 2310016D23Rik ENSMUST00000348174.1 2310016D23Rik (from geneSymbol) AK009383 uc337dxw.1 uc337dxw.1 
ENSMUST00000348181.1 ENSMUSG00000138488 ENSMUST00000348181.1 ENSMUSG00000138488 (from geneSymbol) uc337dyd.1 uc337dyd.1 
ENSMUST00000348183.1 ENSMUSG00000138489 ENSMUST00000348183.1 ENSMUSG00000138489 (from geneSymbol) uc337dyf.1 uc337dyf.1 
ENSMUST00000348186.1 ENSMUSG00000138490 ENSMUST00000348186.1 ENSMUSG00000138490 (from geneSymbol) uc337dyi.1 uc337dyi.1 
ENSMUST00000348203.1 Gm34304 ENSMUST00000348203.1 Gm34304 (from geneSymbol) uc337dyz.1 uc337dyz.1 
ENSMUST00000348221.1 Gm16685 ENSMUST00000348221.1 Gm16685 (from geneSymbol) AK151815 uc337dzr.1 uc337dzr.1 
ENSMUST00000348240.1 ENSMUSG00000138491 ENSMUST00000348240.1 ENSMUSG00000138491 (from geneSymbol) uc337eak.1 uc337eak.1 
ENSMUST00000348244.1 ENSMUSG00000138492 ENSMUST00000348244.1 ENSMUSG00000138492 (from geneSymbol) uc337eao.1 uc337eao.1 
ENSMUST00000348246.1 ENSMUSG00000138493 ENSMUST00000348246.1 ENSMUSG00000138493 (from geneSymbol) uc337eaq.1 uc337eaq.1 
ENSMUST00000348248.1 ENSMUSG00000138494 ENSMUST00000348248.1 ENSMUSG00000138494 (from geneSymbol) uc337eas.1 uc337eas.1 
ENSMUST00000348253.1 ENSMUSG00000138495 ENSMUST00000348253.1 ENSMUSG00000138495 (from geneSymbol) uc337eax.1 uc337eax.1 
ENSMUST00000348254.1 ENSMUSG00000138496 ENSMUST00000348254.1 ENSMUSG00000138496 (from geneSymbol) uc337eay.1 uc337eay.1 
ENSMUST00000348266.1 ENSMUSG00000138497 ENSMUST00000348266.1 ENSMUSG00000138497 (from geneSymbol) uc337ebk.1 uc337ebk.1 
ENSMUST00000348271.1 ENSMUSG00000138498 ENSMUST00000348271.1 ENSMUSG00000138498 (from geneSymbol) uc337ebp.1 uc337ebp.1 
ENSMUST00000348273.1 ENSMUSG00000138499 ENSMUST00000348273.1 ENSMUSG00000138499 (from geneSymbol) uc337ebr.1 uc337ebr.1 
ENSMUST00000348274.1 ENSMUSG00000138500 ENSMUST00000348274.1 ENSMUSG00000138500 (from geneSymbol) uc337ebs.1 uc337ebs.1 
ENSMUST00000348275.1 ENSMUSG00000138501 ENSMUST00000348275.1 ENSMUSG00000138501 (from geneSymbol) uc337ebt.1 uc337ebt.1 
ENSMUST00000348278.1 ENSMUSG00000138502 ENSMUST00000348278.1 ENSMUSG00000138502 (from geneSymbol) uc337ebw.1 uc337ebw.1 
ENSMUST00000348280.1 ENSMUSG00000138504 ENSMUST00000348280.1 ENSMUSG00000138504 (from geneSymbol) uc337ebx.1 uc337ebx.1 
ENSMUST00000348282.1 ENSMUSG00000138505 ENSMUST00000348282.1 ENSMUSG00000138505 (from geneSymbol) uc337ebz.1 uc337ebz.1 
ENSMUST00000348283.1 Gm14697 ENSMUST00000348283.1 Gm14697 (from geneSymbol) AK039412 uc337eca.1 uc337eca.1 
ENSMUST00000348285.1 Gm17098 ENSMUST00000348285.1 Gm17098 (from geneSymbol) uc337ecc.1 uc337ecc.1 
ENSMUST00000348286.1 ENSMUSG00000138506 ENSMUST00000348286.1 ENSMUSG00000138506 (from geneSymbol) uc337ecd.1 uc337ecd.1 
ENSMUST00000348289.1 ENSMUSG00000138507 ENSMUST00000348289.1 ENSMUSG00000138507 (from geneSymbol) uc337ecg.1 uc337ecg.1 
ENSMUST00000348290.1 ENSMUSG00000138508 ENSMUST00000348290.1 ENSMUSG00000138508 (from geneSymbol) uc337ech.1 uc337ech.1 
ENSMUST00000348291.1 Gm47514 ENSMUST00000348291.1 Gm47514 (from geneSymbol) uc337eci.1 uc337eci.1 
ENSMUST00000348297.1 ENSMUSG00000138509 ENSMUST00000348297.1 ENSMUSG00000138509 (from geneSymbol) uc337eco.1 uc337eco.1 
ENSMUST00000348298.1 ENSMUSG00000138510 ENSMUST00000348298.1 ENSMUSG00000138510 (from geneSymbol) uc337ecp.1 uc337ecp.1 
ENSMUST00000348307.1 ENSMUSG00000138511 ENSMUST00000348307.1 ENSMUSG00000138511 (from geneSymbol) uc337ecy.1 uc337ecy.1 
ENSMUST00000348311.1 A530013C23Rik ENSMUST00000348311.1 A530013C23Rik (from geneSymbol) AK040674 uc337edc.1 uc337edc.1 
ENSMUST00000348321.1 ENSMUSG00000138512 ENSMUST00000348321.1 ENSMUSG00000138512 (from geneSymbol) uc337edm.1 uc337edm.1 
ENSMUST00000348326.1 ENSMUSG00000138513 ENSMUST00000348326.1 ENSMUSG00000138513 (from geneSymbol) uc337edr.1 uc337edr.1 
ENSMUST00000348328.1 ENSMUSG00000138514 ENSMUST00000348328.1 ENSMUSG00000138514 (from geneSymbol) uc337edt.1 uc337edt.1 
ENSMUST00000348347.1 Gm57587 ENSMUST00000348347.1 Gm57587 (from geneSymbol) uc337eel.1 uc337eel.1 
ENSMUST00000348348.1 Gm12869 ENSMUST00000348348.1 Gm12869 (from geneSymbol) uc337eem.1 uc337eem.1 
ENSMUST00000348349.1 ENSMUSG00000138515 ENSMUST00000348349.1 ENSMUSG00000138515 (from geneSymbol) uc337een.1 uc337een.1 
ENSMUST00000348352.1 Gm35097 ENSMUST00000348352.1 Gm35097 (from geneSymbol) uc337eeq.1 uc337eeq.1 
ENSMUST00000348359.1 ENSMUSG00000138516 ENSMUST00000348359.1 ENSMUSG00000138516 (from geneSymbol) uc337eex.1 uc337eex.1 
ENSMUST00000348364.1 Gm17344 ENSMUST00000348364.1 Gm17344 (from geneSymbol) AK038784 uc337efc.1 uc337efc.1 
ENSMUST00000348384.1 ENSMUSG00000138517 ENSMUST00000348384.1 ENSMUSG00000138517 (from geneSymbol) uc337efw.1 uc337efw.1 
ENSMUST00000348385.1 ENSMUSG00000138518 ENSMUST00000348385.1 ENSMUSG00000138518 (from geneSymbol) uc337efx.1 uc337efx.1 
ENSMUST00000348394.1 ENSMUSG00000138519 ENSMUST00000348394.1 ENSMUSG00000138519 (from geneSymbol) uc337egg.1 uc337egg.1 
ENSMUST00000348395.1 ENSMUSG00000138520 ENSMUST00000348395.1 ENSMUSG00000138520 (from geneSymbol) uc337egh.1 uc337egh.1 
ENSMUST00000348397.1 ENSMUSG00000138522 ENSMUST00000348397.1 ENSMUSG00000138522 (from geneSymbol) uc337egi.1 uc337egi.1 
ENSMUST00000348399.1 ENSMUSG00000138523 ENSMUST00000348399.1 ENSMUSG00000138523 (from geneSymbol) uc337egk.1 uc337egk.1 
ENSMUST00000348403.1 Gm31510 ENSMUST00000348403.1 Gm31510 (from geneSymbol) uc337ego.1 uc337ego.1 
ENSMUST00000348421.1 Gm11579 ENSMUST00000348421.1 Gm11579 (from geneSymbol) KY467491 uc337ehg.1 uc337ehg.1 
ENSMUST00000348425.1 ENSMUSG00000138524 ENSMUST00000348425.1 ENSMUSG00000138524 (from geneSymbol) uc337ehk.1 uc337ehk.1 
ENSMUST00000348428.1 ENSMUSG00000138525 ENSMUST00000348428.1 ENSMUSG00000138525 (from geneSymbol) uc337ehm.1 uc337ehm.1 
ENSMUST00000348429.1 ENSMUSG00000138526 ENSMUST00000348429.1 ENSMUSG00000138526 (from geneSymbol) uc337ehn.1 uc337ehn.1 
ENSMUST00000348430.1 ENSMUSG00000138527 ENSMUST00000348430.1 ENSMUSG00000138527 (from geneSymbol) uc337eho.1 uc337eho.1 
ENSMUST00000348433.1 ENSMUSG00000138528 ENSMUST00000348433.1 ENSMUSG00000138528 (from geneSymbol) uc337ehr.1 uc337ehr.1 
ENSMUST00000348435.1 ENSMUSG00000138529 ENSMUST00000348435.1 ENSMUSG00000138529 (from geneSymbol) uc337eht.1 uc337eht.1 
ENSMUST00000348436.1 ENSMUSG00000138530 ENSMUST00000348436.1 ENSMUSG00000138530 (from geneSymbol) uc337ehu.1 uc337ehu.1 
ENSMUST00000348440.1 ENSMUSG00000138531 ENSMUST00000348440.1 ENSMUSG00000138531 (from geneSymbol) uc337ehy.1 uc337ehy.1 
ENSMUST00000348526.1 ENSMUSG00000138532 ENSMUST00000348526.1 ENSMUSG00000138532 (from geneSymbol) uc337elg.1 uc337elg.1 
ENSMUST00000348529.1 ENSMUSG00000138533 ENSMUST00000348529.1 ENSMUSG00000138533 (from geneSymbol) uc337elj.1 uc337elj.1 
ENSMUST00000348533.1 Gm35244 ENSMUST00000348533.1 Gm35244 (from geneSymbol) uc337eln.1 uc337eln.1 
ENSMUST00000348538.1 ENSMUSG00000138535 ENSMUST00000348538.1 ENSMUSG00000138535 (from geneSymbol) uc337els.1 uc337els.1 
ENSMUST00000348540.1 ENSMUSG00000138536 ENSMUST00000348540.1 ENSMUSG00000138536 (from geneSymbol) uc337elu.1 uc337elu.1 
ENSMUST00000348541.1 ENSMUSG00000138537 ENSMUST00000348541.1 ENSMUSG00000138537 (from geneSymbol) uc337elv.1 uc337elv.1 
ENSMUST00000348542.1 ENSMUSG00000138538 ENSMUST00000348542.1 ENSMUSG00000138538 (from geneSymbol) uc337elw.1 uc337elw.1 
ENSMUST00000348546.1 ENSMUSG00000138539 ENSMUST00000348546.1 ENSMUSG00000138539 (from geneSymbol) uc337ema.1 uc337ema.1 
ENSMUST00000348548.1 ENSMUSG00000138540 ENSMUST00000348548.1 ENSMUSG00000138540 (from geneSymbol) uc337emc.1 uc337emc.1 
ENSMUST00000348550.1 ENSMUSG00000138541 ENSMUST00000348550.1 ENSMUSG00000138541 (from geneSymbol) uc337eme.1 uc337eme.1 
ENSMUST00000348551.1 ENSMUSG00000138542 ENSMUST00000348551.1 ENSMUSG00000138542 (from geneSymbol) uc337emf.1 uc337emf.1 
ENSMUST00000348552.1 4732463B04Rik ENSMUST00000348552.1 4732463B04Rik (from geneSymbol) AK132490 uc337emg.1 uc337emg.1 
ENSMUST00000348554.1 Gm11378 ENSMUST00000348554.1 Gm11378 (from geneSymbol) uc337emi.1 uc337emi.1 
ENSMUST00000348556.1 ENSMUSG00000138543 ENSMUST00000348556.1 ENSMUSG00000138543 (from geneSymbol) uc337emk.1 uc337emk.1 
ENSMUST00000348557.1 Gm33677 ENSMUST00000348557.1 Gm33677 (from geneSymbol) AK132971 uc337eml.1 uc337eml.1 
ENSMUST00000348587.1 ENSMUSG00000138544 ENSMUST00000348587.1 ENSMUSG00000138544 (from geneSymbol) uc337enp.1 uc337enp.1 
ENSMUST00000348600.1 4930478P22Rik ENSMUST00000348600.1 4930478P22Rik (from geneSymbol) AK015590 uc337eoc.1 uc337eoc.1 
ENSMUST00000348604.1 ENSMUSG00000138545 ENSMUST00000348604.1 ENSMUSG00000138545 (from geneSymbol) uc337eog.1 uc337eog.1 
ENSMUST00000348607.1 2010016I18Rik ENSMUST00000348607.1 2010016I18Rik (from geneSymbol) AK080971 uc337eoj.1 uc337eoj.1 
ENSMUST00000348612.1 ENSMUSG00000138546 ENSMUST00000348612.1 ENSMUSG00000138546 (from geneSymbol) uc337eoo.1 uc337eoo.1 
ENSMUST00000348615.1 ENSMUSG00000138549 ENSMUST00000348615.1 ENSMUSG00000138549 (from geneSymbol) uc337eop.1 uc337eop.1 
ENSMUST00000348617.1 ENSMUSG00000138550 ENSMUST00000348617.1 ENSMUSG00000138550 (from geneSymbol) uc337eor.1 uc337eor.1 
ENSMUST00000348618.1 ENSMUSG00000138551 ENSMUST00000348618.1 ENSMUSG00000138551 (from geneSymbol) uc337eos.1 uc337eos.1 
ENSMUST00000348620.1 ENSMUSG00000138553 ENSMUST00000348620.1 ENSMUSG00000138553 (from geneSymbol) uc337eot.1 uc337eot.1 
ENSMUST00000348621.1 ENSMUSG00000138554 ENSMUST00000348621.1 ENSMUSG00000138554 (from geneSymbol) uc337eou.1 uc337eou.1 
ENSMUST00000348622.1 ENSMUSG00000138555 ENSMUST00000348622.1 ENSMUSG00000138555 (from geneSymbol) uc337eov.1 uc337eov.1 
ENSMUST00000348623.1 ENSMUSG00000138556 ENSMUST00000348623.1 ENSMUSG00000138556 (from geneSymbol) uc337eow.1 uc337eow.1 
ENSMUST00000348624.1 ENSMUSG00000138557 ENSMUST00000348624.1 ENSMUSG00000138557 (from geneSymbol) uc337eox.1 uc337eox.1 
ENSMUST00000348634.1 ENSMUSG00000138558 ENSMUST00000348634.1 ENSMUSG00000138558 (from geneSymbol) uc337eph.1 uc337eph.1 
ENSMUST00000348635.1 ENSMUSG00000138559 ENSMUST00000348635.1 ENSMUSG00000138559 (from geneSymbol) uc337epi.1 uc337epi.1 
ENSMUST00000348638.1 ENSMUSG00000138560 ENSMUST00000348638.1 ENSMUSG00000138560 (from geneSymbol) KY467478 uc337epl.1 uc337epl.1 
ENSMUST00000348639.1 Gm57309 ENSMUST00000348639.1 Gm57309 (from geneSymbol) uc337epm.1 uc337epm.1 
ENSMUST00000348642.1 ENSMUSG00000138561 ENSMUST00000348642.1 ENSMUSG00000138561 (from geneSymbol) uc337epp.1 uc337epp.1 
ENSMUST00000348643.1 4931422A03Rik ENSMUST00000348643.1 4931422A03Rik (from geneSymbol) AK076716 uc337epq.1 uc337epq.1 
ENSMUST00000348669.1 ENSMUSG00000138562 ENSMUST00000348669.1 ENSMUSG00000138562 (from geneSymbol) uc337eqq.1 uc337eqq.1 
ENSMUST00000348671.1 ENSMUSG00000138563 ENSMUST00000348671.1 ENSMUSG00000138563 (from geneSymbol) uc337eqs.1 uc337eqs.1 
ENSMUST00000348672.1 ENSMUSG00000138564 ENSMUST00000348672.1 ENSMUSG00000138564 (from geneSymbol) uc337eqt.1 uc337eqt.1 
ENSMUST00000348675.1 ENSMUSG00000138565 ENSMUST00000348675.1 ENSMUSG00000138565 (from geneSymbol) uc337eqw.1 uc337eqw.1 
ENSMUST00000348685.1 ENSMUSG00000138566 ENSMUST00000348685.1 ENSMUSG00000138566 (from geneSymbol) uc337erg.1 uc337erg.1 
ENSMUST00000348698.1 Gm42151 ENSMUST00000348698.1 predicted gene, 42151, transcript variant 3 (from RefSeq NR_168910.1) NR_168910 uc337ert.1 uc337ert.1 
ENSMUST00000348703.1 ENSMUSG00000138568 ENSMUST00000348703.1 ENSMUSG00000138568 (from geneSymbol) uc337ery.1 uc337ery.1 
ENSMUST00000348716.1 Gm56518 ENSMUST00000348716.1 Gm56518 (from geneSymbol) uc337esl.1 uc337esl.1 
ENSMUST00000348720.1 ENSMUSG00000138569 ENSMUST00000348720.1 ENSMUSG00000138569 (from geneSymbol) uc337esp.1 uc337esp.1 
ENSMUST00000348723.1 ENSMUSG00000138570 ENSMUST00000348723.1 ENSMUSG00000138570 (from geneSymbol) uc337ess.1 uc337ess.1 
ENSMUST00000348724.1 ENSMUSG00000138571 ENSMUST00000348724.1 ENSMUSG00000138571 (from geneSymbol) uc337est.1 uc337est.1 
ENSMUST00000348725.1 ENSMUSG00000138572 ENSMUST00000348725.1 ENSMUSG00000138572 (from geneSymbol) uc337esu.1 uc337esu.1 
ENSMUST00000348726.1 ENSMUSG00000138573 ENSMUST00000348726.1 ENSMUSG00000138573 (from geneSymbol) uc337esv.1 uc337esv.1 
ENSMUST00000348727.1 ENSMUSG00000138574 ENSMUST00000348727.1 ENSMUSG00000138574 (from geneSymbol) uc337esw.1 uc337esw.1 
ENSMUST00000348729.1 ENSMUSG00000138575 ENSMUST00000348729.1 ENSMUSG00000138575 (from geneSymbol) uc337esy.1 uc337esy.1 
ENSMUST00000348735.1 ENSMUSG00000138576 ENSMUST00000348735.1 ENSMUSG00000138576 (from geneSymbol) uc337ete.1 uc337ete.1 
ENSMUST00000348743.1 ENSMUSG00000138577 ENSMUST00000348743.1 ENSMUSG00000138577 (from geneSymbol) uc337etm.1 uc337etm.1 
ENSMUST00000348744.1 ENSMUSG00000138578 ENSMUST00000348744.1 ENSMUSG00000138578 (from geneSymbol) uc337etn.1 uc337etn.1 
ENSMUST00000348745.1 Gm57182 ENSMUST00000348745.1 Gm57182 (from geneSymbol) uc337eto.1 uc337eto.1 
ENSMUST00000348750.1 ENSMUSG00000138579 ENSMUST00000348750.1 ENSMUSG00000138579 (from geneSymbol) uc337ett.1 uc337ett.1 
ENSMUST00000348754.1 ENSMUSG00000138580 ENSMUST00000348754.1 ENSMUSG00000138580 (from geneSymbol) uc337etx.1 uc337etx.1 
ENSMUST00000348755.1 ENSMUSG00000138581 ENSMUST00000348755.1 ENSMUSG00000138581 (from geneSymbol) uc337ety.1 uc337ety.1 
ENSMUST00000348756.1 ENSMUSG00000138582 ENSMUST00000348756.1 ENSMUSG00000138582 (from geneSymbol) uc337etz.1 uc337etz.1 
ENSMUST00000348758.1 Gm15492 ENSMUST00000348758.1 Gm15492 (from geneSymbol) AK016007 uc337eub.1 uc337eub.1 
ENSMUST00000348763.1 ENSMUSG00000138583 ENSMUST00000348763.1 ENSMUSG00000138583 (from geneSymbol) uc337eug.1 uc337eug.1 
ENSMUST00000348764.1 Gm48970 ENSMUST00000348764.1 Gm48970 (from geneSymbol) uc337euh.1 uc337euh.1 
ENSMUST00000348765.1 ENSMUSG00000138584 ENSMUST00000348765.1 ENSMUSG00000138584 (from geneSymbol) uc337eui.1 uc337eui.1 
ENSMUST00000348772.1 ENSMUSG00000138585 ENSMUST00000348772.1 ENSMUSG00000138585 (from geneSymbol) uc337eup.1 uc337eup.1 
ENSMUST00000348774.1 ENSMUSG00000138586 ENSMUST00000348774.1 ENSMUSG00000138586 (from geneSymbol) uc337eur.1 uc337eur.1 
ENSMUST00000348776.1 ENSMUSG00000138587 ENSMUST00000348776.1 ENSMUSG00000138587 (from geneSymbol) AK006494 uc337eut.1 uc337eut.1 
ENSMUST00000348777.1 ENSMUSG00000138588 ENSMUST00000348777.1 ENSMUSG00000138588 (from geneSymbol) uc337euu.1 uc337euu.1 
ENSMUST00000348782.1 ENSMUSG00000138589 ENSMUST00000348782.1 ENSMUSG00000138589 (from geneSymbol) uc337euz.1 uc337euz.1 
ENSMUST00000348795.1 ENSMUSG00000138590 ENSMUST00000348795.1 ENSMUSG00000138590 (from geneSymbol) uc337evm.1 uc337evm.1 
ENSMUST00000348805.1 ENSMUSG00000138591 ENSMUST00000348805.1 ENSMUSG00000138591 (from geneSymbol) uc337evw.1 uc337evw.1 
ENSMUST00000348806.1 ENSMUSG00000138592 ENSMUST00000348806.1 ENSMUSG00000138592 (from geneSymbol) uc337evx.1 uc337evx.1 
ENSMUST00000348807.1 ENSMUSG00000138593 ENSMUST00000348807.1 ENSMUSG00000138593 (from geneSymbol) uc337evy.1 uc337evy.1 
ENSMUST00000348808.1 ENSMUSG00000138594 ENSMUST00000348808.1 ENSMUSG00000138594 (from geneSymbol) AK019131 uc337evz.1 uc337evz.1 
ENSMUST00000348810.1 ENSMUSG00000138595 ENSMUST00000348810.1 ENSMUSG00000138595 (from geneSymbol) uc337ewb.1 uc337ewb.1 
ENSMUST00000348815.1 ENSMUSG00000138596 ENSMUST00000348815.1 ENSMUSG00000138596 (from geneSymbol) uc337ewg.1 uc337ewg.1 
ENSMUST00000348829.1 ENSMUSG00000138597 ENSMUST00000348829.1 ENSMUSG00000138597 (from geneSymbol) uc337ewu.1 uc337ewu.1 
ENSMUST00000348831.1 ENSMUSG00000138598 ENSMUST00000348831.1 ENSMUSG00000138598 (from geneSymbol) uc337eww.1 uc337eww.1 
ENSMUST00000348835.1 ENSMUSG00000138600 ENSMUST00000348835.1 ENSMUSG00000138600 (from geneSymbol) uc337ewz.1 uc337ewz.1 
ENSMUST00000348836.1 ENSMUSG00000138601 ENSMUST00000348836.1 ENSMUSG00000138601 (from geneSymbol) uc337exa.1 uc337exa.1 
ENSMUST00000348837.1 ENSMUSG00000138602 ENSMUST00000348837.1 ENSMUSG00000138602 (from geneSymbol) uc337exb.1 uc337exb.1 
ENSMUST00000348838.1 ENSMUSG00000138603 ENSMUST00000348838.1 ENSMUSG00000138603 (from geneSymbol) uc337exc.1 uc337exc.1 
ENSMUST00000348840.1 ENSMUSG00000138605 ENSMUST00000348840.1 ENSMUSG00000138605 (from geneSymbol) uc337exd.1 uc337exd.1 
ENSMUST00000348841.1 ENSMUSG00000138606 ENSMUST00000348841.1 ENSMUSG00000138606 (from geneSymbol) uc337exe.1 uc337exe.1 
ENSMUST00000348847.1 ENSMUSG00000138607 ENSMUST00000348847.1 ENSMUSG00000138607 (from geneSymbol) uc337exk.1 uc337exk.1 
ENSMUST00000348849.1 Gm49518 ENSMUST00000348849.1 Gm49518 (from geneSymbol) AK143977 uc337exm.1 uc337exm.1 
ENSMUST00000348866.1 ENSMUSG00000138608 ENSMUST00000348866.1 ENSMUSG00000138608 (from geneSymbol) uc337eyd.1 uc337eyd.1 
ENSMUST00000348868.1 ENSMUSG00000138609 ENSMUST00000348868.1 ENSMUSG00000138609 (from geneSymbol) uc337eyf.1 uc337eyf.1 
ENSMUST00000348871.1 ENSMUSG00000138610 ENSMUST00000348871.1 ENSMUSG00000138610 (from geneSymbol) uc337eyi.1 uc337eyi.1 
ENSMUST00000348878.1 4930461G14Rik ENSMUST00000348878.1 4930461G14Rik (from geneSymbol) AK015493 uc337eyp.1 uc337eyp.1 
ENSMUST00000348893.1 ENSMUSG00000138611 ENSMUST00000348893.1 ENSMUSG00000138611 (from geneSymbol) uc337eze.1 uc337eze.1 
ENSMUST00000348910.1 ENSMUSG00000138613 ENSMUST00000348910.1 ENSMUSG00000138613 (from geneSymbol) uc337ezu.1 uc337ezu.1 
ENSMUST00000348925.1 ENSMUSG00000138614 ENSMUST00000348925.1 ENSMUSG00000138614 (from geneSymbol) uc337fah.1 uc337fah.1 
ENSMUST00000348928.1 ENSMUSG00000138615 ENSMUST00000348928.1 ENSMUSG00000138615 (from geneSymbol) LF202624 uc337fak.1 uc337fak.1 
ENSMUST00000348931.1 ENSMUSG00000138616 ENSMUST00000348931.1 ENSMUSG00000138616 (from geneSymbol) uc337fan.1 uc337fan.1 
ENSMUST00000348936.1 ENSMUSG00000138617 ENSMUST00000348936.1 ENSMUSG00000138617 (from geneSymbol) uc337fas.1 uc337fas.1 
ENSMUST00000348937.1 ENSMUSG00000138618 ENSMUST00000348937.1 ENSMUSG00000138618 (from geneSymbol) uc337fat.1 uc337fat.1 
ENSMUST00000348938.1 ENSMUSG00000138619 ENSMUST00000348938.1 ENSMUSG00000138619 (from geneSymbol) uc337fau.1 uc337fau.1 
ENSMUST00000348942.1 ENSMUSG00000138620 ENSMUST00000348942.1 ENSMUSG00000138620 (from geneSymbol) uc337fay.1 uc337fay.1 
ENSMUST00000348944.1 Gm37982 ENSMUST00000348944.1 Gm37982 (from geneSymbol) uc337fba.1 uc337fba.1 
ENSMUST00000348947.1 ENSMUSG00000138621 ENSMUST00000348947.1 ENSMUSG00000138621 (from geneSymbol) uc337fbd.1 uc337fbd.1 
ENSMUST00000348949.1 ENSMUSG00000138622 ENSMUST00000348949.1 ENSMUSG00000138622 (from geneSymbol) uc337fbf.1 uc337fbf.1 
ENSMUST00000348950.1 ENSMUSG00000138623 ENSMUST00000348950.1 ENSMUSG00000138623 (from geneSymbol) uc337fbg.1 uc337fbg.1 
ENSMUST00000348952.1 ENSMUSG00000138624 ENSMUST00000348952.1 ENSMUSG00000138624 (from geneSymbol) uc337fbi.1 uc337fbi.1 
ENSMUST00000348953.1 ENSMUSG00000138625 ENSMUST00000348953.1 ENSMUSG00000138625 (from geneSymbol) AK047583 uc337fbj.1 uc337fbj.1 
ENSMUST00000348954.1 ENSMUSG00000138626 ENSMUST00000348954.1 ENSMUSG00000138626 (from geneSymbol) uc337fbk.1 uc337fbk.1 
ENSMUST00000348958.1 ENSMUSG00000138627 ENSMUST00000348958.1 ENSMUSG00000138627 (from geneSymbol) uc337fbo.1 uc337fbo.1 
ENSMUST00000348959.1 ENSMUSG00000138628 ENSMUST00000348959.1 ENSMUSG00000138628 (from geneSymbol) uc337fbp.1 uc337fbp.1 
ENSMUST00000348960.1 ENSMUSG00000138629 ENSMUST00000348960.1 ENSMUSG00000138629 (from geneSymbol) uc337fbq.1 uc337fbq.1 
ENSMUST00000348962.1 ENSMUSG00000138630 ENSMUST00000348962.1 ENSMUSG00000138630 (from geneSymbol) uc337fbs.1 uc337fbs.1 
ENSMUST00000348964.1 ENSMUSG00000138631 ENSMUST00000348964.1 ENSMUSG00000138631 (from geneSymbol) uc337fbu.1 uc337fbu.1 
ENSMUST00000348966.1 ENSMUSG00000138632 ENSMUST00000348966.1 ENSMUSG00000138632 (from geneSymbol) uc337fbw.1 uc337fbw.1 
ENSMUST00000348967.1 ENSMUSG00000138633 ENSMUST00000348967.1 ENSMUSG00000138633 (from geneSymbol) uc337fbx.1 uc337fbx.1 
ENSMUST00000348968.1 ENSMUSG00000138634 ENSMUST00000348968.1 ENSMUSG00000138634 (from geneSymbol) uc337fby.1 uc337fby.1 
ENSMUST00000348970.1 ENSMUSG00000138635 ENSMUST00000348970.1 ENSMUSG00000138635 (from geneSymbol) uc337fca.1 uc337fca.1 
ENSMUST00000348971.1 ENSMUSG00000138636 ENSMUST00000348971.1 ENSMUSG00000138636 (from geneSymbol) uc337fcb.1 uc337fcb.1 
ENSMUST00000348973.1 ENSMUSG00000138637 ENSMUST00000348973.1 ENSMUSG00000138637 (from geneSymbol) uc337fcd.1 uc337fcd.1 
ENSMUST00000348976.1 ENSMUSG00000138639 ENSMUST00000348976.1 ENSMUSG00000138639 (from geneSymbol) uc337fcf.1 uc337fcf.1 
ENSMUST00000348977.1 ENSMUSG00000138640 ENSMUST00000348977.1 ENSMUSG00000138640 (from geneSymbol) uc337fcg.1 uc337fcg.1 
ENSMUST00000348982.1 ENSMUSG00000138641 ENSMUST00000348982.1 ENSMUSG00000138641 (from geneSymbol) uc337fcl.1 uc337fcl.1 
ENSMUST00000348985.1 ENSMUSG00000138642 ENSMUST00000348985.1 ENSMUSG00000138642 (from geneSymbol) uc337fco.1 uc337fco.1 
ENSMUST00000348986.1 ENSMUSG00000138643 ENSMUST00000348986.1 ENSMUSG00000138643 (from geneSymbol) uc337fcp.1 uc337fcp.1 
ENSMUST00000348987.1 ENSMUSG00000138644 ENSMUST00000348987.1 ENSMUSG00000138644 (from geneSymbol) uc337fcq.1 uc337fcq.1 
ENSMUST00000349011.1 ENSMUSG00000138645 ENSMUST00000349011.1 ENSMUSG00000138645 (from geneSymbol) uc337fdo.1 uc337fdo.1 
ENSMUST00000349012.1 ENSMUSG00000138646 ENSMUST00000349012.1 ENSMUSG00000138646 (from geneSymbol) uc337fdp.1 uc337fdp.1 
ENSMUST00000349013.1 4930432B10Rik ENSMUST00000349013.1 4930432B10Rik (from geneSymbol) AK015283 uc337fdq.1 uc337fdq.1 
ENSMUST00000349022.1 ENSMUSG00000138647 ENSMUST00000349022.1 ENSMUSG00000138647 (from geneSymbol) uc337fdz.1 uc337fdz.1 
ENSMUST00000349031.1 ENSMUSG00000138648 ENSMUST00000349031.1 ENSMUSG00000138648 (from geneSymbol) uc337fei.1 uc337fei.1 
ENSMUST00000349038.1 ENSMUSG00000138649 ENSMUST00000349038.1 ENSMUSG00000138649 (from geneSymbol) uc337fep.1 uc337fep.1 
ENSMUST00000349040.1 ENSMUSG00000138650 ENSMUST00000349040.1 ENSMUSG00000138650 (from geneSymbol) uc337fer.1 uc337fer.1 
ENSMUST00000349041.1 ENSMUSG00000138651 ENSMUST00000349041.1 ENSMUSG00000138651 (from geneSymbol) uc337fes.1 uc337fes.1 
ENSMUST00000349042.1 ENSMUSG00000138652 ENSMUST00000349042.1 ENSMUSG00000138652 (from geneSymbol) uc337fet.1 uc337fet.1 
ENSMUST00000349044.1 ENSMUSG00000138653 ENSMUST00000349044.1 ENSMUSG00000138653 (from geneSymbol) uc337fev.1 uc337fev.1 
ENSMUST00000349051.1 ENSMUSG00000138654 ENSMUST00000349051.1 ENSMUSG00000138654 (from geneSymbol) uc337ffc.1 uc337ffc.1 
ENSMUST00000349067.1 ENSMUSG00000138655 ENSMUST00000349067.1 ENSMUSG00000138655 (from geneSymbol) uc337ffs.1 uc337ffs.1 
ENSMUST00000349077.1 Gm57079 ENSMUST00000349077.1 Gm57079 (from geneSymbol) uc337fgc.1 uc337fgc.1 
ENSMUST00000349080.1 ENSMUSG00000138656 ENSMUST00000349080.1 ENSMUSG00000138656 (from geneSymbol) uc337fgf.1 uc337fgf.1 
ENSMUST00000349081.1 ENSMUSG00000138657 ENSMUST00000349081.1 ENSMUSG00000138657 (from geneSymbol) uc337fgg.1 uc337fgg.1 
ENSMUST00000349082.1 ENSMUSG00000138658 ENSMUST00000349082.1 ENSMUSG00000138658 (from geneSymbol) AK028807 uc337fgh.1 uc337fgh.1 
ENSMUST00000349086.1 ENSMUSG00000138659 ENSMUST00000349086.1 ENSMUSG00000138659 (from geneSymbol) uc337fgl.1 uc337fgl.1 
ENSMUST00000349087.1 ENSMUSG00000138660 ENSMUST00000349087.1 ENSMUSG00000138660 (from geneSymbol) uc337fgm.1 uc337fgm.1 
ENSMUST00000349090.1 ENSMUSG00000138661 ENSMUST00000349090.1 ENSMUSG00000138661 (from geneSymbol) AK006024 uc337fgp.1 uc337fgp.1 
ENSMUST00000349095.1 ENSMUSG00000138662 ENSMUST00000349095.1 ENSMUSG00000138662 (from geneSymbol) uc337fgu.1 uc337fgu.1 
ENSMUST00000349096.1 ENSMUSG00000138663 ENSMUST00000349096.1 ENSMUSG00000138663 (from geneSymbol) uc337fgv.1 uc337fgv.1 
ENSMUST00000349098.1 Gm2453 ENSMUST00000349098.1 Gm2453 (from geneSymbol) uc337fgx.1 uc337fgx.1 
ENSMUST00000349100.1 ENSMUSG00000138664 ENSMUST00000349100.1 ENSMUSG00000138664 (from geneSymbol) uc337fgz.1 uc337fgz.1 
ENSMUST00000349101.1 ENSMUSG00000138665 ENSMUST00000349101.1 ENSMUSG00000138665 (from geneSymbol) uc337fha.1 uc337fha.1 
ENSMUST00000349102.1 ENSMUSG00000138666 ENSMUST00000349102.1 ENSMUSG00000138666 (from geneSymbol) uc337fhb.1 uc337fhb.1 
ENSMUST00000349111.1 ENSMUSG00000138667 ENSMUST00000349111.1 ENSMUSG00000138667 (from geneSymbol) uc337fhk.1 uc337fhk.1 
ENSMUST00000349115.1 Gm15738 ENSMUST00000349115.1 Gm15738 (from geneSymbol) AK131759 uc337fho.1 uc337fho.1 
ENSMUST00000349151.1 Gm15477 ENSMUST00000349151.1 Gm15477 (from geneSymbol) AK076825 uc337fiy.1 uc337fiy.1 
ENSMUST00000349156.1 ENSMUSG00000138668 ENSMUST00000349156.1 ENSMUSG00000138668 (from geneSymbol) uc337fjd.1 uc337fjd.1 
ENSMUST00000349159.1 ENSMUSG00000138669 ENSMUST00000349159.1 ENSMUSG00000138669 (from geneSymbol) uc337fjg.1 uc337fjg.1 
ENSMUST00000349160.1 ENSMUSG00000138670 ENSMUST00000349160.1 ENSMUSG00000138670 (from geneSymbol) uc337fjh.1 uc337fjh.1 
ENSMUST00000349167.1 ENSMUSG00000138671 ENSMUST00000349167.1 ENSMUSG00000138671 (from geneSymbol) uc337fjo.1 uc337fjo.1 
ENSMUST00000349168.1 ENSMUSG00000138672 ENSMUST00000349168.1 ENSMUSG00000138672 (from geneSymbol) uc337fjp.1 uc337fjp.1 
ENSMUST00000349169.1 ENSMUSG00000138673 ENSMUST00000349169.1 ENSMUSG00000138673 (from geneSymbol) uc337fjq.1 uc337fjq.1 
ENSMUST00000349170.1 ENSMUSG00000138674 ENSMUST00000349170.1 ENSMUSG00000138674 (from geneSymbol) uc337fjr.1 uc337fjr.1 
ENSMUST00000349171.1 ENSMUSG00000138675 ENSMUST00000349171.1 ENSMUSG00000138675 (from geneSymbol) uc337fjs.1 uc337fjs.1 
ENSMUST00000349173.1 Gm28563 ENSMUST00000349173.1 Gm28563 (from geneSymbol) uc337fju.1 uc337fju.1 
ENSMUST00000349183.1 ENSMUSG00000138676 ENSMUST00000349183.1 ENSMUSG00000138676 (from geneSymbol) uc337fke.1 uc337fke.1 
ENSMUST00000349184.1 ENSMUSG00000138677 ENSMUST00000349184.1 ENSMUSG00000138677 (from geneSymbol) uc337fkf.1 uc337fkf.1 
ENSMUST00000349185.1 ENSMUSG00000138678 ENSMUST00000349185.1 ENSMUSG00000138678 (from geneSymbol) uc337fkg.1 uc337fkg.1 
ENSMUST00000349187.1 ENSMUSG00000138679 ENSMUST00000349187.1 ENSMUSG00000138679 (from geneSymbol) uc337fki.1 uc337fki.1 
ENSMUST00000349188.1 ENSMUSG00000138680 ENSMUST00000349188.1 ENSMUSG00000138680 (from geneSymbol) AK016106 uc337fkj.1 uc337fkj.1 
ENSMUST00000349190.1 ENSMUSG00000138681 ENSMUST00000349190.1 ENSMUSG00000138681 (from geneSymbol) uc337fkl.1 uc337fkl.1 
ENSMUST00000349191.1 ENSMUSG00000138682 ENSMUST00000349191.1 ENSMUSG00000138682 (from geneSymbol) uc337fkm.1 uc337fkm.1 
ENSMUST00000349197.1 ENSMUSG00000138683 ENSMUST00000349197.1 ENSMUSG00000138683 (from geneSymbol) uc337fks.1 uc337fks.1 
ENSMUST00000349198.1 ENSMUSG00000138684 ENSMUST00000349198.1 ENSMUSG00000138684 (from geneSymbol) uc337fkt.1 uc337fkt.1 
ENSMUST00000349199.1 ENSMUSG00000138685 ENSMUST00000349199.1 ENSMUSG00000138685 (from geneSymbol) uc337fku.1 uc337fku.1 
ENSMUST00000349220.1 ENSMUSG00000138686 ENSMUST00000349220.1 ENSMUSG00000138686 (from geneSymbol) DQ694443 uc337flp.1 uc337flp.1 
ENSMUST00000349221.1 ENSMUSG00000138687 ENSMUST00000349221.1 ENSMUSG00000138687 (from geneSymbol) uc337flq.1 uc337flq.1 
ENSMUST00000349222.1 ENSMUSG00000138688 ENSMUST00000349222.1 ENSMUSG00000138688 (from geneSymbol) uc337flr.1 uc337flr.1 
ENSMUST00000349223.1 ENSMUSG00000138689 ENSMUST00000349223.1 ENSMUSG00000138689 (from geneSymbol) uc337fls.1 uc337fls.1 
ENSMUST00000349224.1 ENSMUSG00000138690 ENSMUST00000349224.1 ENSMUSG00000138690 (from geneSymbol) uc337flt.1 uc337flt.1 
ENSMUST00000349225.1 ENSMUSG00000138691 ENSMUST00000349225.1 ENSMUSG00000138691 (from geneSymbol) uc337flu.1 uc337flu.1 
ENSMUST00000349227.1 Gm56938 ENSMUST00000349227.1 Gm56938 (from geneSymbol) uc337flw.1 uc337flw.1 
ENSMUST00000349229.1 ENSMUSG00000138692 ENSMUST00000349229.1 ENSMUSG00000138692 (from geneSymbol) uc337fly.1 uc337fly.1 
ENSMUST00000349230.1 ENSMUSG00000138693 ENSMUST00000349230.1 ENSMUSG00000138693 (from geneSymbol) uc337flz.1 uc337flz.1 
ENSMUST00000349249.1 ENSMUSG00000138694 ENSMUST00000349249.1 ENSMUSG00000138694 (from geneSymbol) uc337fms.1 uc337fms.1 
ENSMUST00000349250.1 ENSMUSG00000138695 ENSMUST00000349250.1 ENSMUSG00000138695 (from geneSymbol) uc337fmt.1 uc337fmt.1 
ENSMUST00000349258.1 ENSMUSG00000138696 ENSMUST00000349258.1 ENSMUSG00000138696 (from geneSymbol) uc337fmv.1 uc337fmv.1 
ENSMUST00000349260.1 Gm29230 ENSMUST00000349260.1 Gm29230 (from geneSymbol) AK132084 uc337fmx.1 uc337fmx.1 
ENSMUST00000349264.1 ENSMUSG00000138697 ENSMUST00000349264.1 ENSMUSG00000138697 (from geneSymbol) uc337fnb.1 uc337fnb.1 
ENSMUST00000349268.1 ENSMUSG00000138698 ENSMUST00000349268.1 ENSMUSG00000138698 (from geneSymbol) uc337fnf.1 uc337fnf.1 
ENSMUST00000349269.1 ENSMUSG00000138699 ENSMUST00000349269.1 ENSMUSG00000138699 (from geneSymbol) uc337fng.1 uc337fng.1 
ENSMUST00000349270.1 ENSMUSG00000138700 ENSMUST00000349270.1 ENSMUSG00000138700 (from geneSymbol) uc337fnh.1 uc337fnh.1 
ENSMUST00000349279.1 ENSMUSG00000138701 ENSMUST00000349279.1 ENSMUSG00000138701 (from geneSymbol) uc337fnq.1 uc337fnq.1 
ENSMUST00000349280.1 Gm49662 ENSMUST00000349280.1 Gm49662 (from geneSymbol) uc337fnr.1 uc337fnr.1 
ENSMUST00000349282.1 ENSMUSG00000138702 ENSMUST00000349282.1 ENSMUSG00000138702 (from geneSymbol) uc337fnt.1 uc337fnt.1 
ENSMUST00000349286.1 Gm15482 ENSMUST00000349286.1 Gm15482 (from geneSymbol) AK142406 uc337fnx.1 uc337fnx.1 
ENSMUST00000349288.1 ENSMUSG00000138703 ENSMUST00000349288.1 ENSMUSG00000138703 (from geneSymbol) uc337fnz.1 uc337fnz.1 
ENSMUST00000349289.1 ENSMUSG00000138704 ENSMUST00000349289.1 ENSMUSG00000138704 (from geneSymbol) uc337foa.1 uc337foa.1 
ENSMUST00000349290.1 ENSMUSG00000138705 ENSMUST00000349290.1 ENSMUSG00000138705 (from geneSymbol) uc337fob.1 uc337fob.1 
ENSMUST00000349292.1 ENSMUSG00000138706 ENSMUST00000349292.1 ENSMUSG00000138706 (from geneSymbol) uc337fod.1 uc337fod.1 
ENSMUST00000349294.1 ENSMUSG00000138707 ENSMUST00000349294.1 ENSMUSG00000138707 (from geneSymbol) uc337fof.1 uc337fof.1 
ENSMUST00000349301.1 Gm50163 ENSMUST00000349301.1 Gm50163 (from geneSymbol) uc337fom.1 uc337fom.1 
ENSMUST00000349304.1 ENSMUSG00000138708 ENSMUST00000349304.1 ENSMUSG00000138708 (from geneSymbol) uc337fop.1 uc337fop.1 
ENSMUST00000349305.1 ENSMUSG00000138709 ENSMUST00000349305.1 ENSMUSG00000138709 (from geneSymbol) uc337foq.1 uc337foq.1 
ENSMUST00000349306.1 ENSMUSG00000138710 ENSMUST00000349306.1 ENSMUSG00000138710 (from geneSymbol) uc337for.1 uc337for.1 
ENSMUST00000349321.1 4930425K10Rik ENSMUST00000349321.1 4930425K10Rik (from geneSymbol) AK015200 uc337fpg.1 uc337fpg.1 
ENSMUST00000349330.1 ENSMUSG00000138711 ENSMUST00000349330.1 ENSMUSG00000138711 (from geneSymbol) uc337fpp.1 uc337fpp.1 
ENSMUST00000349332.1 Gm43221 ENSMUST00000349332.1 Gm43221 (from geneSymbol) uc337fpr.1 uc337fpr.1 
ENSMUST00000349333.1 ENSMUSG00000138712 ENSMUST00000349333.1 ENSMUSG00000138712 (from geneSymbol) uc337fps.1 uc337fps.1 
ENSMUST00000349334.1 ENSMUSG00000138713 ENSMUST00000349334.1 ENSMUSG00000138713 (from geneSymbol) uc337fpt.1 uc337fpt.1 
ENSMUST00000349338.1 Gm52698 ENSMUST00000349338.1 Gm52698 (from geneSymbol) uc337fpx.1 uc337fpx.1 
ENSMUST00000349346.1 ENSMUSG00000138714 ENSMUST00000349346.1 ENSMUSG00000138714 (from geneSymbol) uc337fqf.1 uc337fqf.1 
ENSMUST00000349347.1 ENSMUSG00000138715 ENSMUST00000349347.1 ENSMUSG00000138715 (from geneSymbol) uc337fqg.1 uc337fqg.1 
ENSMUST00000349350.1 ENSMUSG00000138716 ENSMUST00000349350.1 ENSMUSG00000138716 (from geneSymbol) uc337fqj.1 uc337fqj.1 
ENSMUST00000349351.1 ENSMUSG00000138717 ENSMUST00000349351.1 ENSMUSG00000138717 (from geneSymbol) uc337fqk.1 uc337fqk.1 
ENSMUST00000349352.1 Gm31938 ENSMUST00000349352.1 Gm31938 (from geneSymbol) AK077964 uc337fql.1 uc337fql.1 
ENSMUST00000349362.1 Gm34322 ENSMUST00000349362.1 Gm34322 (from geneSymbol) uc337fqv.1 uc337fqv.1 
ENSMUST00000349449.1 ENSMUSG00000138718 ENSMUST00000349449.1 ENSMUSG00000138718 (from geneSymbol) LF199518 uc337fue.1 uc337fue.1 
ENSMUST00000349450.1 ENSMUSG00000138719 ENSMUST00000349450.1 ENSMUSG00000138719 (from geneSymbol) uc337fuf.1 uc337fuf.1 
ENSMUST00000349453.1 ENSMUSG00000138720 ENSMUST00000349453.1 ENSMUSG00000138720 (from geneSymbol) uc337fui.1 uc337fui.1 
ENSMUST00000349454.1 ENSMUSG00000138721 ENSMUST00000349454.1 ENSMUSG00000138721 (from geneSymbol) uc337fuj.1 uc337fuj.1 
ENSMUST00000349457.1 ENSMUSG00000138722 ENSMUST00000349457.1 ENSMUSG00000138722 (from geneSymbol) uc337fum.1 uc337fum.1 
ENSMUST00000349462.1 ENSMUSG00000138723 ENSMUST00000349462.1 ENSMUSG00000138723 (from geneSymbol) uc337fur.1 uc337fur.1 
ENSMUST00000349463.1 ENSMUSG00000138724 ENSMUST00000349463.1 ENSMUSG00000138724 (from geneSymbol) uc337fus.1 uc337fus.1 
ENSMUST00000349464.1 ENSMUSG00000138725 ENSMUST00000349464.1 ENSMUSG00000138725 (from geneSymbol) uc337fut.1 uc337fut.1 
ENSMUST00000349465.1 ENSMUSG00000138726 ENSMUST00000349465.1 ENSMUSG00000138726 (from geneSymbol) uc337fuu.1 uc337fuu.1 
ENSMUST00000349466.1 ENSMUSG00000138727 ENSMUST00000349466.1 ENSMUSG00000138727 (from geneSymbol) uc337fuv.1 uc337fuv.1 
ENSMUST00000349473.1 ENSMUSG00000138728 ENSMUST00000349473.1 ENSMUSG00000138728 (from geneSymbol) uc337fvc.1 uc337fvc.1 
ENSMUST00000349476.1 ENSMUSG00000138729 ENSMUST00000349476.1 ENSMUSG00000138729 (from geneSymbol) uc337fvf.1 uc337fvf.1 
ENSMUST00000349480.1 ENSMUSG00000138730 ENSMUST00000349480.1 ENSMUSG00000138730 (from geneSymbol) uc337fvj.1 uc337fvj.1 
ENSMUST00000349491.1 ENSMUSG00000138731 ENSMUST00000349491.1 ENSMUSG00000138731 (from geneSymbol) uc337fvu.1 uc337fvu.1 
ENSMUST00000349492.1 ENSMUSG00000138732 ENSMUST00000349492.1 ENSMUSG00000138732 (from geneSymbol) uc337fvv.1 uc337fvv.1 
ENSMUST00000349493.1 ENSMUSG00000138733 ENSMUST00000349493.1 ENSMUSG00000138733 (from geneSymbol) L04852 uc337fvw.1 uc337fvw.1 
ENSMUST00000349495.1 ENSMUSG00000138734 ENSMUST00000349495.1 ENSMUSG00000138734 (from geneSymbol) uc337fvy.1 uc337fvy.1 
ENSMUST00000349496.1 ENSMUSG00000138735 ENSMUST00000349496.1 ENSMUSG00000138735 (from geneSymbol) uc337fvz.1 uc337fvz.1 
ENSMUST00000349497.1 ENSMUSG00000138736 ENSMUST00000349497.1 ENSMUSG00000138736 (from geneSymbol) uc337fwa.1 uc337fwa.1 
ENSMUST00000349498.1 ENSMUSG00000138737 ENSMUST00000349498.1 ENSMUSG00000138737 (from geneSymbol) uc337fwb.1 uc337fwb.1 
ENSMUST00000349499.1 ENSMUSG00000138738 ENSMUST00000349499.1 ENSMUSG00000138738 (from geneSymbol) uc337fwc.1 uc337fwc.1 
ENSMUST00000349500.1 ENSMUSG00000138739 ENSMUST00000349500.1 ENSMUSG00000138739 (from geneSymbol) uc337fwd.1 uc337fwd.1 
ENSMUST00000349502.1 ENSMUSG00000138740 ENSMUST00000349502.1 ENSMUSG00000138740 (from geneSymbol) uc337fwf.1 uc337fwf.1 
ENSMUST00000349503.1 ENSMUSG00000138741 ENSMUST00000349503.1 ENSMUSG00000138741 (from geneSymbol) uc337fwg.1 uc337fwg.1 
ENSMUST00000349505.1 ENSMUSG00000138742 ENSMUST00000349505.1 ENSMUSG00000138742 (from geneSymbol) uc337fwi.1 uc337fwi.1 
ENSMUST00000349506.1 ENSMUSG00000138743 ENSMUST00000349506.1 ENSMUSG00000138743 (from geneSymbol) uc337fwj.1 uc337fwj.1 
ENSMUST00000349508.1 ENSMUSG00000138744 ENSMUST00000349508.1 ENSMUSG00000138744 (from geneSymbol) uc337fwl.1 uc337fwl.1 
ENSMUST00000349509.1 ENSMUSG00000138745 ENSMUST00000349509.1 ENSMUSG00000138745 (from geneSymbol) uc337fwm.1 uc337fwm.1 
ENSMUST00000349511.1 ENSMUSG00000138746 ENSMUST00000349511.1 ENSMUSG00000138746 (from geneSymbol) uc337fwo.1 uc337fwo.1 
ENSMUST00000349512.1 ENSMUSG00000138747 ENSMUST00000349512.1 ENSMUSG00000138747 (from geneSymbol) uc337fwp.1 uc337fwp.1 
ENSMUST00000349513.1 ENSMUSG00000138748 ENSMUST00000349513.1 ENSMUSG00000138748 (from geneSymbol) uc337fwq.1 uc337fwq.1 
ENSMUST00000349514.1 ENSMUSG00000138749 ENSMUST00000349514.1 ENSMUSG00000138749 (from geneSymbol) uc337fwr.1 uc337fwr.1 
ENSMUST00000349519.1 ENSMUSG00000138750 ENSMUST00000349519.1 ENSMUSG00000138750 (from geneSymbol) uc337fww.1 uc337fww.1 
ENSMUST00000349520.1 ENSMUSG00000138751 ENSMUST00000349520.1 ENSMUSG00000138751 (from geneSymbol) uc337fwx.1 uc337fwx.1 
ENSMUST00000349521.1 ENSMUSG00000138752 ENSMUST00000349521.1 ENSMUSG00000138752 (from geneSymbol) uc337fwy.1 uc337fwy.1 
ENSMUST00000349522.1 ENSMUSG00000138753 ENSMUST00000349522.1 ENSMUSG00000138753 (from geneSymbol) uc337fwz.1 uc337fwz.1 
ENSMUST00000349523.1 ENSMUSG00000138754 ENSMUST00000349523.1 ENSMUSG00000138754 (from geneSymbol) uc337fxa.1 uc337fxa.1 
ENSMUST00000349528.1 ENSMUSG00000138755 ENSMUST00000349528.1 ENSMUSG00000138755 (from geneSymbol) AK085058 uc337fxf.1 uc337fxf.1 
ENSMUST00000349532.1 ENSMUSG00000138756 ENSMUST00000349532.1 ENSMUSG00000138756 (from geneSymbol) uc337fxj.1 uc337fxj.1 
ENSMUST00000349533.1 ENSMUSG00000138757 ENSMUST00000349533.1 ENSMUSG00000138757 (from geneSymbol) uc337fxk.1 uc337fxk.1 
ENSMUST00000349534.1 ENSMUSG00000138758 ENSMUST00000349534.1 ENSMUSG00000138758 (from geneSymbol) uc337fxl.1 uc337fxl.1 
ENSMUST00000349535.1 ENSMUSG00000138759 ENSMUST00000349535.1 ENSMUSG00000138759 (from geneSymbol) uc337fxm.1 uc337fxm.1 
ENSMUST00000349539.1 ENSMUSG00000138760 ENSMUST00000349539.1 ENSMUSG00000138760 (from geneSymbol) uc337fxq.1 uc337fxq.1 
ENSMUST00000349544.1 ENSMUSG00000138761 ENSMUST00000349544.1 ENSMUSG00000138761 (from geneSymbol) uc337fxv.1 uc337fxv.1 
ENSMUST00000349547.1 ENSMUSG00000138762 ENSMUST00000349547.1 ENSMUSG00000138762 (from geneSymbol) uc337fxy.1 uc337fxy.1 
ENSMUST00000349549.1 ENSMUSG00000138763 ENSMUST00000349549.1 ENSMUSG00000138763 (from geneSymbol) uc337fya.1 uc337fya.1 
ENSMUST00000349563.1 ENSMUSG00000138764 ENSMUST00000349563.1 ENSMUSG00000138764 (from geneSymbol) uc337fyo.1 uc337fyo.1 
ENSMUST00000349565.1 ENSMUSG00000138765 ENSMUST00000349565.1 ENSMUSG00000138765 (from geneSymbol) uc337fyp.1 uc337fyp.1 
ENSMUST00000349566.1 ENSMUSG00000138766 ENSMUST00000349566.1 ENSMUSG00000138766 (from geneSymbol) uc337fyq.1 uc337fyq.1 
ENSMUST00000349567.1 ENSMUSG00000138767 ENSMUST00000349567.1 ENSMUSG00000138767 (from geneSymbol) uc337fyr.1 uc337fyr.1 
ENSMUST00000349568.1 ENSMUSG00000138768 ENSMUST00000349568.1 ENSMUSG00000138768 (from geneSymbol) uc337fys.1 uc337fys.1 
ENSMUST00000349570.1 ENSMUSG00000138769 ENSMUST00000349570.1 ENSMUSG00000138769 (from geneSymbol) uc337fyu.1 uc337fyu.1 
ENSMUST00000349571.1 4933430M04Rik ENSMUST00000349571.1 4933430M04Rik (from geneSymbol) AK016999 uc337fyv.1 uc337fyv.1 
ENSMUST00000349581.1 ENSMUSG00000138770 ENSMUST00000349581.1 ENSMUSG00000138770 (from geneSymbol) uc337fzf.1 uc337fzf.1 
ENSMUST00000349583.1 ENSMUSG00000138771 ENSMUST00000349583.1 ENSMUSG00000138771 (from geneSymbol) uc337fzh.1 uc337fzh.1 
ENSMUST00000349585.1 ENSMUSG00000138772 ENSMUST00000349585.1 ENSMUSG00000138772 (from geneSymbol) uc337fzj.1 uc337fzj.1 
ENSMUST00000349586.1 ENSMUSG00000138773 ENSMUST00000349586.1 ENSMUSG00000138773 (from geneSymbol) uc337fzk.1 uc337fzk.1 
ENSMUST00000349590.1 ENSMUSG00000138774 ENSMUST00000349590.1 ENSMUSG00000138774 (from geneSymbol) uc337fzo.1 uc337fzo.1 
ENSMUST00000349591.1 Gm49975 ENSMUST00000349591.1 Gm49975 (from geneSymbol) uc337fzp.1 uc337fzp.1 
ENSMUST00000349593.1 ENSMUSG00000138775 ENSMUST00000349593.1 ENSMUSG00000138775 (from geneSymbol) uc337fzr.1 uc337fzr.1 
ENSMUST00000349607.1 ENSMUSG00000138777 ENSMUST00000349607.1 ENSMUSG00000138777 (from geneSymbol) uc337gae.1 uc337gae.1 
ENSMUST00000349611.1 ENSMUSG00000138778 ENSMUST00000349611.1 ENSMUSG00000138778 (from geneSymbol) uc337gai.1 uc337gai.1 
ENSMUST00000349615.1 Gm40153 ENSMUST00000349615.1 Gm40153 (from geneSymbol) uc337gam.1 uc337gam.1 
ENSMUST00000349625.1 ENSMUSG00000138779 ENSMUST00000349625.1 ENSMUSG00000138779 (from geneSymbol) uc337gaw.1 uc337gaw.1 
ENSMUST00000349628.1 ENSMUSG00000138780 ENSMUST00000349628.1 ENSMUSG00000138780 (from geneSymbol) uc337gaz.1 uc337gaz.1 
ENSMUST00000349629.1 ENSMUSG00000138781 ENSMUST00000349629.1 ENSMUSG00000138781 (from geneSymbol) uc337gba.1 uc337gba.1 
ENSMUST00000349630.1 ENSMUSG00000138782 ENSMUST00000349630.1 ENSMUSG00000138782 (from geneSymbol) uc337gbb.1 uc337gbb.1 
ENSMUST00000349631.1 ENSMUSG00000138783 ENSMUST00000349631.1 ENSMUSG00000138783 (from geneSymbol) uc337gbc.1 uc337gbc.1 
ENSMUST00000349632.1 ENSMUSG00000138784 ENSMUST00000349632.1 ENSMUSG00000138784 (from geneSymbol) uc337gbd.1 uc337gbd.1 
ENSMUST00000349633.1 ENSMUSG00000138785 ENSMUST00000349633.1 ENSMUSG00000138785 (from geneSymbol) uc337gbe.1 uc337gbe.1 
ENSMUST00000349635.1 ENSMUSG00000138786 ENSMUST00000349635.1 ENSMUSG00000138786 (from geneSymbol) uc337gbg.1 uc337gbg.1 
ENSMUST00000349640.1 ENSMUSG00000138787 ENSMUST00000349640.1 ENSMUSG00000138787 (from geneSymbol) uc337gbl.1 uc337gbl.1 
ENSMUST00000349643.1 ENSMUSG00000138788 ENSMUST00000349643.1 ENSMUSG00000138788 (from geneSymbol) uc337gbo.1 uc337gbo.1 
ENSMUST00000349644.1 ENSMUSG00000138789 ENSMUST00000349644.1 ENSMUSG00000138789 (from geneSymbol) uc337gbp.1 uc337gbp.1 
ENSMUST00000349647.1 ENSMUSG00000138790 ENSMUST00000349647.1 ENSMUSG00000138790 (from geneSymbol) uc337gbs.1 uc337gbs.1 
ENSMUST00000349650.1 ENSMUSG00000138791 ENSMUST00000349650.1 ENSMUSG00000138791 (from geneSymbol) uc337gbv.1 uc337gbv.1 
ENSMUST00000349657.1 ENSMUSG00000138792 ENSMUST00000349657.1 ENSMUSG00000138792 (from geneSymbol) uc337gcc.1 uc337gcc.1 
ENSMUST00000349678.1 ENSMUSG00000138793 ENSMUST00000349678.1 ENSMUSG00000138793 (from geneSymbol) uc337gcx.1 uc337gcx.1 
ENSMUST00000349679.1 ENSMUSG00000138794 ENSMUST00000349679.1 ENSMUSG00000138794 (from geneSymbol) uc337gcy.1 uc337gcy.1 
ENSMUST00000349681.1 ENSMUSG00000138795 ENSMUST00000349681.1 ENSMUSG00000138795 (from geneSymbol) uc337gda.1 uc337gda.1 
ENSMUST00000349683.1 ENSMUSG00000138796 ENSMUST00000349683.1 ENSMUSG00000138796 (from geneSymbol) uc337gdc.1 uc337gdc.1 
ENSMUST00000349684.1 ENSMUSG00000138797 ENSMUST00000349684.1 ENSMUSG00000138797 (from geneSymbol) uc337gdd.1 uc337gdd.1 
ENSMUST00000349686.1 ENSMUSG00000138798 ENSMUST00000349686.1 ENSMUSG00000138798 (from geneSymbol) uc337gdf.1 uc337gdf.1 
ENSMUST00000349693.1 ENSMUSG00000138799 ENSMUST00000349693.1 ENSMUSG00000138799 (from geneSymbol) uc337gdm.1 uc337gdm.1 
ENSMUST00000349694.1 ENSMUSG00000138800 ENSMUST00000349694.1 ENSMUSG00000138800 (from geneSymbol) uc337gdn.1 uc337gdn.1 
ENSMUST00000349696.1 ENSMUSG00000138801 ENSMUST00000349696.1 ENSMUSG00000138801 (from geneSymbol) uc337gdp.1 uc337gdp.1 
ENSMUST00000349697.1 ENSMUSG00000138802 ENSMUST00000349697.1 ENSMUSG00000138802 (from geneSymbol) uc337gdq.1 uc337gdq.1 
ENSMUST00000349706.1 ENSMUSG00000138803 ENSMUST00000349706.1 ENSMUSG00000138803 (from geneSymbol) uc337gdz.1 uc337gdz.1 
ENSMUST00000349708.1 ENSMUSG00000138804 ENSMUST00000349708.1 ENSMUSG00000138804 (from geneSymbol) uc337geb.1 uc337geb.1 
ENSMUST00000349709.1 ENSMUSG00000138805 ENSMUST00000349709.1 ENSMUSG00000138805 (from geneSymbol) uc337gec.1 uc337gec.1 
ENSMUST00000349712.1 Gm16087 ENSMUST00000349712.1 Gm16087 (from geneSymbol) AK132125 uc337gef.1 uc337gef.1 
ENSMUST00000349721.1 ENSMUSG00000138806 ENSMUST00000349721.1 ENSMUSG00000138806 (from geneSymbol) uc337geo.1 uc337geo.1 
ENSMUST00000349725.1 ENSMUSG00000138807 ENSMUST00000349725.1 ENSMUSG00000138807 (from geneSymbol) uc337ges.1 uc337ges.1 
ENSMUST00000349727.1 ENSMUSG00000138808 ENSMUST00000349727.1 ENSMUSG00000138808 (from geneSymbol) uc337geu.1 uc337geu.1 
ENSMUST00000349728.1 ENSMUSG00000138809 ENSMUST00000349728.1 ENSMUSG00000138809 (from geneSymbol) uc337gev.1 uc337gev.1 
ENSMUST00000349729.1 ENSMUSG00000138810 ENSMUST00000349729.1 ENSMUSG00000138810 (from geneSymbol) uc337gew.1 uc337gew.1 
ENSMUST00000349730.1 ENSMUSG00000138811 ENSMUST00000349730.1 ENSMUSG00000138811 (from geneSymbol) uc337gex.1 uc337gex.1 
ENSMUST00000349731.1 ENSMUSG00000138812 ENSMUST00000349731.1 ENSMUSG00000138812 (from geneSymbol) uc337gey.1 uc337gey.1 
ENSMUST00000349736.1 Gm12551 ENSMUST00000349736.1 Gm12551 (from geneSymbol) uc337gfd.1 uc337gfd.1 
ENSMUST00000349744.1 ENSMUSG00000138814 ENSMUST00000349744.1 ENSMUSG00000138814 (from geneSymbol) uc337gfl.1 uc337gfl.1 
ENSMUST00000349745.1 ENSMUSG00000138815 ENSMUST00000349745.1 ENSMUSG00000138815 (from geneSymbol) uc337gfm.1 uc337gfm.1 
ENSMUST00000349746.1 ENSMUSG00000138816 ENSMUST00000349746.1 ENSMUSG00000138816 (from geneSymbol) uc337gfn.1 uc337gfn.1 
ENSMUST00000349749.1 ENSMUSG00000138817 ENSMUST00000349749.1 ENSMUSG00000138817 (from geneSymbol) uc337gfq.1 uc337gfq.1 
ENSMUST00000349751.1 Gm17308 ENSMUST00000349751.1 Gm17308 (from geneSymbol) AK142469 uc337gfs.1 uc337gfs.1 
ENSMUST00000349763.1 ENSMUSG00000138818 ENSMUST00000349763.1 ENSMUSG00000138818 (from geneSymbol) uc337gge.1 uc337gge.1 
ENSMUST00000349766.1 ENSMUSG00000138819 ENSMUST00000349766.1 ENSMUSG00000138819 (from geneSymbol) AK079974 uc337ggh.1 uc337ggh.1 
ENSMUST00000349768.1 ENSMUSG00000138820 ENSMUST00000349768.1 ENSMUSG00000138820 (from geneSymbol) uc337ggj.1 uc337ggj.1 
ENSMUST00000349769.1 ENSMUSG00000138821 ENSMUST00000349769.1 ENSMUSG00000138821 (from geneSymbol) uc337ggk.1 uc337ggk.1 
ENSMUST00000349770.1 ENSMUSG00000138822 ENSMUST00000349770.1 ENSMUSG00000138822 (from geneSymbol) uc337ggl.1 uc337ggl.1 
ENSMUST00000349775.1 Gm42567 ENSMUST00000349775.1 Gm42567 (from geneSymbol) uc337ggq.1 uc337ggq.1 
ENSMUST00000349778.1 ENSMUSG00000138823 ENSMUST00000349778.1 ENSMUSG00000138823 (from geneSymbol) uc337ggt.1 uc337ggt.1 
ENSMUST00000349784.1 ENSMUSG00000138824 ENSMUST00000349784.1 ENSMUSG00000138824 (from geneSymbol) uc337ggz.1 uc337ggz.1 
ENSMUST00000349787.1 ENSMUSG00000138825 ENSMUST00000349787.1 ENSMUSG00000138825 (from geneSymbol) uc337ghc.1 uc337ghc.1 
ENSMUST00000349789.1 ENSMUSG00000138826 ENSMUST00000349789.1 ENSMUSG00000138826 (from geneSymbol) EF410150 uc337ghe.1 uc337ghe.1 
ENSMUST00000349794.1 Gm6117 ENSMUST00000349794.1 Gm6117 (from geneSymbol) AK132717 uc337ghj.1 uc337ghj.1 
ENSMUST00000349796.1 ENSMUSG00000138827 ENSMUST00000349796.1 ENSMUSG00000138827 (from geneSymbol) uc337ghl.1 uc337ghl.1 
ENSMUST00000349801.1 ENSMUSG00000138828 ENSMUST00000349801.1 ENSMUSG00000138828 (from geneSymbol) uc337ghq.1 uc337ghq.1 
ENSMUST00000349803.1 ENSMUSG00000138829 ENSMUST00000349803.1 ENSMUSG00000138829 (from geneSymbol) uc337ghs.1 uc337ghs.1 
ENSMUST00000349804.1 ENSMUSG00000138830 ENSMUST00000349804.1 ENSMUSG00000138830 (from geneSymbol) uc337ght.1 uc337ght.1 
ENSMUST00000349832.1 ENSMUSG00000138831 ENSMUST00000349832.1 ENSMUSG00000138831 (from geneSymbol) uc337giv.1 uc337giv.1 
ENSMUST00000349843.1 ENSMUSG00000138832 ENSMUST00000349843.1 ENSMUSG00000138832 (from geneSymbol) uc337gjg.1 uc337gjg.1 
ENSMUST00000349853.1 ENSMUSG00000138833 ENSMUST00000349853.1 ENSMUSG00000138833 (from geneSymbol) uc337gjq.1 uc337gjq.1 
ENSMUST00000349854.1 ENSMUSG00000138834 ENSMUST00000349854.1 ENSMUSG00000138834 (from geneSymbol) uc337gjr.1 uc337gjr.1 
ENSMUST00000349858.1 4933438B17Rik ENSMUST00000349858.1 4933438B17Rik (from geneSymbol) AK017106 uc337gjv.1 uc337gjv.1 
ENSMUST00000349890.1 ENSMUSG00000138835 ENSMUST00000349890.1 ENSMUSG00000138835 (from geneSymbol) uc337glb.1 uc337glb.1 
ENSMUST00000349894.1 ENSMUSG00000138836 ENSMUST00000349894.1 ENSMUSG00000138836 (from geneSymbol) uc337glf.1 uc337glf.1 
ENSMUST00000349895.1 ENSMUSG00000138837 ENSMUST00000349895.1 ENSMUSG00000138837 (from geneSymbol) uc337glg.1 uc337glg.1 
ENSMUST00000349896.1 ENSMUSG00000138838 ENSMUST00000349896.1 ENSMUSG00000138838 (from geneSymbol) uc337glh.1 uc337glh.1 
ENSMUST00000349897.1 ENSMUSG00000138839 ENSMUST00000349897.1 ENSMUSG00000138839 (from geneSymbol) uc337gli.1 uc337gli.1 
ENSMUST00000349905.1 Gm7596 ENSMUST00000349905.1 Gm7596 (from geneSymbol) AK145172 uc337glq.1 uc337glq.1 
ENSMUST00000349908.1 ENSMUSG00000138840 ENSMUST00000349908.1 ENSMUSG00000138840 (from geneSymbol) uc337glt.1 uc337glt.1 
ENSMUST00000349910.1 Gm14268 ENSMUST00000349910.1 Gm14268 (from geneSymbol) uc337glv.1 uc337glv.1 
ENSMUST00000349922.1 ENSMUSG00000138841 ENSMUST00000349922.1 ENSMUSG00000138841 (from geneSymbol) uc337gmh.1 uc337gmh.1 
ENSMUST00000349932.1 ENSMUSG00000138842 ENSMUST00000349932.1 ENSMUSG00000138842 (from geneSymbol) uc337gmr.1 uc337gmr.1 
ENSMUST00000349935.1 ENSMUSG00000138843 ENSMUST00000349935.1 ENSMUSG00000138843 (from geneSymbol) uc337gmu.1 uc337gmu.1 
ENSMUST00000349939.1 ENSMUSG00000138844 ENSMUST00000349939.1 ENSMUSG00000138844 (from geneSymbol) AK082358 uc337gmy.1 uc337gmy.1 
ENSMUST00000349945.1 ENSMUSG00000138845 ENSMUST00000349945.1 ENSMUSG00000138845 (from geneSymbol) uc337gne.1 uc337gne.1 
ENSMUST00000349948.1 ENSMUSG00000138846 ENSMUST00000349948.1 ENSMUSG00000138846 (from geneSymbol) uc337gnh.1 uc337gnh.1 
ENSMUST00000349959.1 ENSMUSG00000138847 ENSMUST00000349959.1 ENSMUSG00000138847 (from geneSymbol) uc337gns.1 uc337gns.1 
ENSMUST00000349962.1 ENSMUSG00000138849 ENSMUST00000349962.1 ENSMUSG00000138849 (from geneSymbol) uc337gnu.1 uc337gnu.1 
ENSMUST00000349969.1 Itpr3os ENSMUST00000349969.1 Itpr3os (from geneSymbol) AK131746 uc337goa.1 uc337goa.1 
ENSMUST00000349977.1 ENSMUSG00000138850 ENSMUST00000349977.1 ENSMUSG00000138850 (from geneSymbol) uc337goi.1 uc337goi.1 
ENSMUST00000349978.1 ENSMUSG00000138851 ENSMUST00000349978.1 ENSMUSG00000138851 (from geneSymbol) AK005592 uc337goj.1 uc337goj.1 
ENSMUST00000349982.1 ENSMUSG00000138852 ENSMUST00000349982.1 ENSMUSG00000138852 (from geneSymbol) uc337gon.1 uc337gon.1 
ENSMUST00000349983.1 ENSMUSG00000138853 ENSMUST00000349983.1 ENSMUSG00000138853 (from geneSymbol) uc337goo.1 uc337goo.1 
ENSMUST00000349986.1 ENSMUSG00000138854 ENSMUST00000349986.1 ENSMUSG00000138854 (from geneSymbol) uc337gor.1 uc337gor.1 
ENSMUST00000349996.1 ENSMUSG00000138855 ENSMUST00000349996.1 ENSMUSG00000138855 (from geneSymbol) uc337gpb.1 uc337gpb.1 
ENSMUST00000349997.1 ENSMUSG00000138856 ENSMUST00000349997.1 ENSMUSG00000138856 (from geneSymbol) KY468076 uc337gpc.1 uc337gpc.1 
ENSMUST00000350003.1 ENSMUSG00000138857 ENSMUST00000350003.1 ENSMUSG00000138857 (from geneSymbol) uc337gpi.1 uc337gpi.1 
ENSMUST00000350007.1 Gm57394 ENSMUST00000350007.1 Gm57394 (from geneSymbol) uc337gpm.1 uc337gpm.1 
ENSMUST00000350011.1 ENSMUSG00000138858 ENSMUST00000350011.1 ENSMUSG00000138858 (from geneSymbol) uc337gpq.1 uc337gpq.1 
ENSMUST00000350012.1 ENSMUSG00000138859 ENSMUST00000350012.1 ENSMUSG00000138859 (from geneSymbol) uc337gpr.1 uc337gpr.1 
ENSMUST00000350013.1 ENSMUSG00000138860 ENSMUST00000350013.1 ENSMUSG00000138860 (from geneSymbol) uc337gps.1 uc337gps.1 
ENSMUST00000350014.1 ENSMUSG00000138861 ENSMUST00000350014.1 ENSMUSG00000138861 (from geneSymbol) uc337gpt.1 uc337gpt.1 
ENSMUST00000350019.1 ENSMUSG00000138862 ENSMUST00000350019.1 ENSMUSG00000138862 (from geneSymbol) uc337gpy.1 uc337gpy.1 
ENSMUST00000350027.1 ENSMUSG00000138863 ENSMUST00000350027.1 ENSMUSG00000138863 (from geneSymbol) uc337gqg.1 uc337gqg.1 
ENSMUST00000350030.1 ENSMUSG00000138864 ENSMUST00000350030.1 ENSMUSG00000138864 (from geneSymbol) uc337gqj.1 uc337gqj.1 
ENSMUST00000350033.1 ENSMUSG00000138865 ENSMUST00000350033.1 ENSMUSG00000138865 (from geneSymbol) uc337gqm.1 uc337gqm.1 
ENSMUST00000350034.1 ENSMUSG00000138866 ENSMUST00000350034.1 ENSMUSG00000138866 (from geneSymbol) uc337gqn.1 uc337gqn.1 
ENSMUST00000350035.1 ENSMUSG00000138867 ENSMUST00000350035.1 ENSMUSG00000138867 (from geneSymbol) uc337gqo.1 uc337gqo.1 
ENSMUST00000350036.1 ENSMUSG00000138868 ENSMUST00000350036.1 ENSMUSG00000138868 (from geneSymbol) uc337gqp.1 uc337gqp.1 
ENSMUST00000350038.1 Gm14250 ENSMUST00000350038.1 Gm14250 (from geneSymbol) uc337gqr.1 uc337gqr.1 
ENSMUST00000350052.1 ENSMUSG00000138869 ENSMUST00000350052.1 ENSMUSG00000138869 (from geneSymbol) uc337grf.1 uc337grf.1 
ENSMUST00000350055.1 ENSMUSG00000138870 ENSMUST00000350055.1 ENSMUSG00000138870 (from geneSymbol) uc337gri.1 uc337gri.1 
ENSMUST00000350060.1 Gm3948 ENSMUST00000350060.1 Gm3948 (from geneSymbol) AK161406 uc337grn.1 uc337grn.1 
ENSMUST00000350078.1 ENSMUSG00000138871 ENSMUST00000350078.1 ENSMUSG00000138871 (from geneSymbol) uc337gsf.1 uc337gsf.1 
ENSMUST00000350079.1 ENSMUSG00000138872 ENSMUST00000350079.1 ENSMUSG00000138872 (from geneSymbol) uc337gsg.1 uc337gsg.1 
ENSMUST00000350080.1 ENSMUSG00000138873 ENSMUST00000350080.1 ENSMUSG00000138873 (from geneSymbol) uc337gsh.1 uc337gsh.1 
ENSMUST00000350083.1 Gm47774 ENSMUST00000350083.1 Gm47774 (from geneSymbol) AK076711 uc337gsk.1 uc337gsk.1 
ENSMUST00000350090.1 ENSMUSG00000138874 ENSMUST00000350090.1 ENSMUSG00000138874 (from geneSymbol) uc337gsr.1 uc337gsr.1 
ENSMUST00000350093.1 ENSMUSG00000138875 ENSMUST00000350093.1 ENSMUSG00000138875 (from geneSymbol) uc337gsu.1 uc337gsu.1 
ENSMUST00000350134.1 ENSMUSG00000138876 ENSMUST00000350134.1 ENSMUSG00000138876 (from geneSymbol) uc337guj.1 uc337guj.1 
ENSMUST00000350136.1 ENSMUSG00000138877 ENSMUST00000350136.1 ENSMUSG00000138877 (from geneSymbol) uc337gul.1 uc337gul.1 
ENSMUST00000350137.1 ENSMUSG00000138878 ENSMUST00000350137.1 ENSMUSG00000138878 (from geneSymbol) uc337gum.1 uc337gum.1 
ENSMUST00000350139.1 ENSMUSG00000138879 ENSMUST00000350139.1 ENSMUSG00000138879 (from geneSymbol) uc337guo.1 uc337guo.1 
ENSMUST00000350140.1 ENSMUSG00000138880 ENSMUST00000350140.1 ENSMUSG00000138880 (from geneSymbol) uc337gup.1 uc337gup.1 
ENSMUST00000350142.1 ENSMUSG00000138881 ENSMUST00000350142.1 ENSMUSG00000138881 (from geneSymbol) uc337gur.1 uc337gur.1 
ENSMUST00000350143.1 ENSMUSG00000138882 ENSMUST00000350143.1 ENSMUSG00000138882 (from geneSymbol) uc337gus.1 uc337gus.1 
ENSMUST00000350155.1 ENSMUSG00000138883 ENSMUST00000350155.1 ENSMUSG00000138883 (from geneSymbol) uc337gve.1 uc337gve.1 
ENSMUST00000350191.1 ENSMUSG00000138884 ENSMUST00000350191.1 ENSMUSG00000138884 (from geneSymbol) uc337gwo.1 uc337gwo.1 
ENSMUST00000350192.1 ENSMUSG00000138885 ENSMUST00000350192.1 ENSMUSG00000138885 (from geneSymbol) uc337gwp.1 uc337gwp.1 
ENSMUST00000350193.1 Gm38979 ENSMUST00000350193.1 Gm38979 (from geneSymbol) uc337gwq.1 uc337gwq.1 
ENSMUST00000350198.1 Mir17hg ENSMUST00000350198.1 Mir17hg (from geneSymbol) KY467714 uc337gwu.1 uc337gwu.1 
ENSMUST00000350204.1 ENSMUSG00000138886 ENSMUST00000350204.1 ENSMUSG00000138886 (from geneSymbol) uc337gxa.1 uc337gxa.1 
ENSMUST00000350205.1 ENSMUSG00000138887 ENSMUST00000350205.1 ENSMUSG00000138887 (from geneSymbol) uc337gxb.1 uc337gxb.1 
ENSMUST00000350206.1 ENSMUSG00000138888 ENSMUST00000350206.1 ENSMUSG00000138888 (from geneSymbol) uc337gxc.1 uc337gxc.1 
ENSMUST00000350212.1 Gm41659 ENSMUST00000350212.1 Gm41659 (from geneSymbol) uc337gxi.1 uc337gxi.1 
ENSMUST00000350217.1 ENSMUSG00000138889 ENSMUST00000350217.1 ENSMUSG00000138889 (from geneSymbol) uc337gxn.1 uc337gxn.1 
ENSMUST00000350218.1 ENSMUSG00000138890 ENSMUST00000350218.1 ENSMUSG00000138890 (from geneSymbol) uc337gxo.1 uc337gxo.1 
ENSMUST00000350220.1 ENSMUSG00000138891 ENSMUST00000350220.1 ENSMUSG00000138891 (from geneSymbol) uc337gxq.1 uc337gxq.1 
ENSMUST00000350221.1 Gm49735 ENSMUST00000350221.1 Gm49735 (from geneSymbol) uc337gxr.1 uc337gxr.1 
ENSMUST00000350224.1 ENSMUSG00000138892 ENSMUST00000350224.1 ENSMUSG00000138892 (from geneSymbol) uc337gxu.1 uc337gxu.1 
ENSMUST00000350225.1 ENSMUSG00000138893 ENSMUST00000350225.1 ENSMUSG00000138893 (from geneSymbol) uc337gxv.1 uc337gxv.1 
ENSMUST00000350226.1 ENSMUSG00000138894 ENSMUST00000350226.1 ENSMUSG00000138894 (from geneSymbol) uc337gxw.1 uc337gxw.1 
ENSMUST00000350227.1 ENSMUSG00000138895 ENSMUST00000350227.1 ENSMUSG00000138895 (from geneSymbol) uc337gxx.1 uc337gxx.1 
ENSMUST00000350229.1 ENSMUSG00000138896 ENSMUST00000350229.1 ENSMUSG00000138896 (from geneSymbol) uc337gxz.1 uc337gxz.1 
ENSMUST00000350231.1 ENSMUSG00000138897 ENSMUST00000350231.1 ENSMUSG00000138897 (from geneSymbol) uc337gyb.1 uc337gyb.1 
ENSMUST00000350232.1 ENSMUSG00000138898 ENSMUST00000350232.1 ENSMUSG00000138898 (from geneSymbol) uc337gyc.1 uc337gyc.1 
ENSMUST00000350233.1 ENSMUSG00000138899 ENSMUST00000350233.1 ENSMUSG00000138899 (from geneSymbol) uc337gyd.1 uc337gyd.1 
ENSMUST00000350236.1 ENSMUSG00000138900 ENSMUST00000350236.1 ENSMUSG00000138900 (from geneSymbol) uc337gyg.1 uc337gyg.1 
ENSMUST00000350237.1 ENSMUSG00000138901 ENSMUST00000350237.1 ENSMUSG00000138901 (from geneSymbol) uc337gyh.1 uc337gyh.1 
ENSMUST00000350239.1 ENSMUSG00000138902 ENSMUST00000350239.1 ENSMUSG00000138902 (from geneSymbol) uc337gyj.1 uc337gyj.1 
ENSMUST00000350241.1 ENSMUSG00000138903 ENSMUST00000350241.1 ENSMUSG00000138903 (from geneSymbol) uc337gyl.1 uc337gyl.1 
ENSMUST00000350252.1 Gm28167 ENSMUST00000350252.1 Gm28167 (from geneSymbol) BC048632 uc337gyw.1 uc337gyw.1 
ENSMUST00000350260.1 ENSMUSG00000138904 ENSMUST00000350260.1 ENSMUSG00000138904 (from geneSymbol) uc337gze.1 uc337gze.1 
ENSMUST00000350262.1 ENSMUSG00000138905 ENSMUST00000350262.1 ENSMUSG00000138905 (from geneSymbol) uc337gzg.1 uc337gzg.1 
ENSMUST00000350263.1 ENSMUSG00000138906 ENSMUST00000350263.1 ENSMUSG00000138906 (from geneSymbol) uc337gzh.1 uc337gzh.1 
ENSMUST00000350264.1 ENSMUSG00000138907 ENSMUST00000350264.1 ENSMUSG00000138907 (from geneSymbol) uc337gzi.1 uc337gzi.1 
ENSMUST00000350265.1 ENSMUSG00000138908 ENSMUST00000350265.1 ENSMUSG00000138908 (from geneSymbol) uc337gzj.1 uc337gzj.1 
ENSMUST00000350268.1 ENSMUSG00000138909 ENSMUST00000350268.1 ENSMUSG00000138909 (from geneSymbol) uc337gzm.1 uc337gzm.1 
ENSMUST00000350273.1 ENSMUSG00000138910 ENSMUST00000350273.1 ENSMUSG00000138910 (from geneSymbol) uc337gzr.1 uc337gzr.1 
ENSMUST00000350277.1 ENSMUSG00000138911 ENSMUST00000350277.1 ENSMUSG00000138911 (from geneSymbol) uc337gzv.1 uc337gzv.1 
ENSMUST00000350280.1 E130008D07Rik ENSMUST00000350280.1 E130008D07Rik (from geneSymbol) uc337gzy.1 uc337gzy.1 
ENSMUST00000350293.1 Gm32255 ENSMUST00000350293.1 Gm32255 (from geneSymbol) uc337hal.1 uc337hal.1 
ENSMUST00000350296.1 ENSMUSG00000138912 ENSMUST00000350296.1 ENSMUSG00000138912 (from geneSymbol) uc337hao.1 uc337hao.1 
ENSMUST00000350299.1 Pax1dt ENSMUST00000350299.1 Pax1dt (from geneSymbol) AB080658 uc337har.1 uc337har.1 
ENSMUST00000350302.1 B130055M24Rik ENSMUST00000350302.1 B130055M24Rik (from geneSymbol) AK041042 uc337hau.1 uc337hau.1 
ENSMUST00000350307.1 ENSMUSG00000138913 ENSMUST00000350307.1 ENSMUSG00000138913 (from geneSymbol) uc337hay.1 uc337hay.1 
ENSMUST00000350308.1 ENSMUSG00000138914 ENSMUST00000350308.1 ENSMUSG00000138914 (from geneSymbol) uc337haz.1 uc337haz.1 
ENSMUST00000350320.1 ENSMUSG00000138915 ENSMUST00000350320.1 ENSMUSG00000138915 (from geneSymbol) uc337hbl.1 uc337hbl.1 
ENSMUST00000350321.1 ENSMUSG00000138916 ENSMUST00000350321.1 ENSMUSG00000138916 (from geneSymbol) uc337hbm.1 uc337hbm.1 
ENSMUST00000350322.1 ENSMUSG00000138917 ENSMUST00000350322.1 ENSMUSG00000138917 (from geneSymbol) uc337hbn.1 uc337hbn.1 
ENSMUST00000350324.1 ENSMUSG00000138918 ENSMUST00000350324.1 ENSMUSG00000138918 (from geneSymbol) uc337hbp.1 uc337hbp.1 
ENSMUST00000350326.1 ENSMUSG00000138919 ENSMUST00000350326.1 ENSMUSG00000138919 (from geneSymbol) uc337hbr.1 uc337hbr.1 
ENSMUST00000350328.1 ENSMUSG00000138920 ENSMUST00000350328.1 ENSMUSG00000138920 (from geneSymbol) uc337hbt.1 uc337hbt.1 
ENSMUST00000350330.1 ENSMUSG00000138921 ENSMUST00000350330.1 ENSMUSG00000138921 (from geneSymbol) uc337hbv.1 uc337hbv.1 
ENSMUST00000350331.1 ENSMUSG00000138922 ENSMUST00000350331.1 ENSMUSG00000138922 (from geneSymbol) uc337hbw.1 uc337hbw.1 
ENSMUST00000350333.1 ENSMUSG00000138923 ENSMUST00000350333.1 ENSMUSG00000138923 (from geneSymbol) uc337hby.1 uc337hby.1 
ENSMUST00000350334.1 ENSMUSG00000138924 ENSMUST00000350334.1 ENSMUSG00000138924 (from geneSymbol) uc337hbz.1 uc337hbz.1 
ENSMUST00000350347.1 Gm36459 ENSMUST00000350347.1 Gm36459 (from geneSymbol) uc337hcm.1 uc337hcm.1 
ENSMUST00000350385.1 ENSMUSG00000138925 ENSMUST00000350385.1 ENSMUSG00000138925 (from geneSymbol) uc337hdy.1 uc337hdy.1 
ENSMUST00000350386.1 ENSMUSG00000138926 ENSMUST00000350386.1 ENSMUSG00000138926 (from geneSymbol) uc337hdz.1 uc337hdz.1 
ENSMUST00000350387.1 ENSMUSG00000138927 ENSMUST00000350387.1 ENSMUSG00000138927 (from geneSymbol) uc337hea.1 uc337hea.1 
ENSMUST00000350389.1 ENSMUSG00000138928 ENSMUST00000350389.1 ENSMUSG00000138928 (from geneSymbol) uc337heb.1 uc337heb.1 
ENSMUST00000350390.1 Gm40477 ENSMUST00000350390.1 Gm40477 (from geneSymbol) uc337hec.1 uc337hec.1 
ENSMUST00000350422.1 ENSMUSG00000138929 ENSMUST00000350422.1 ENSMUSG00000138929 (from geneSymbol) uc337hfi.1 uc337hfi.1 
ENSMUST00000350425.1 ENSMUSG00000138930 ENSMUST00000350425.1 ENSMUSG00000138930 (from geneSymbol) AK029663 uc337hfl.1 uc337hfl.1 
ENSMUST00000350446.1 ENSMUSG00000138931 ENSMUST00000350446.1 ENSMUSG00000138931 (from geneSymbol) uc337hgg.1 uc337hgg.1 
ENSMUST00000350447.1 ENSMUSG00000138932 ENSMUST00000350447.1 ENSMUSG00000138932 (from geneSymbol) uc337hgh.1 uc337hgh.1 
ENSMUST00000350448.1 ENSMUSG00000138933 ENSMUST00000350448.1 ENSMUSG00000138933 (from geneSymbol) uc337hgi.1 uc337hgi.1 
ENSMUST00000350450.1 ENSMUSG00000138934 ENSMUST00000350450.1 ENSMUSG00000138934 (from geneSymbol) uc337hgk.1 uc337hgk.1 
ENSMUST00000350454.1 ENSMUSG00000138935 ENSMUST00000350454.1 ENSMUSG00000138935 (from geneSymbol) uc337hgo.1 uc337hgo.1 
ENSMUST00000350456.1 ENSMUSG00000138936 ENSMUST00000350456.1 ENSMUSG00000138936 (from geneSymbol) uc337hgq.1 uc337hgq.1 
ENSMUST00000350459.1 ENSMUSG00000138937 ENSMUST00000350459.1 ENSMUSG00000138937 (from geneSymbol) uc337hgt.1 uc337hgt.1 
ENSMUST00000350464.1 ENSMUSG00000138938 ENSMUST00000350464.1 ENSMUSG00000138938 (from geneSymbol) uc337hgy.1 uc337hgy.1 
ENSMUST00000350465.1 Gm16104 ENSMUST00000350465.1 Gm16104 (from geneSymbol) uc337hgz.1 uc337hgz.1 
ENSMUST00000350472.1 ENSMUSG00000138939 ENSMUST00000350472.1 ENSMUSG00000138939 (from geneSymbol) uc337hhg.1 uc337hhg.1 
ENSMUST00000350474.1 ENSMUSG00000138940 ENSMUST00000350474.1 ENSMUSG00000138940 (from geneSymbol) uc337hhi.1 uc337hhi.1 
ENSMUST00000350479.1 ENSMUSG00000138941 ENSMUST00000350479.1 ENSMUSG00000138941 (from geneSymbol) uc337hhn.1 uc337hhn.1 
ENSMUST00000350482.1 ENSMUSG00000138942 ENSMUST00000350482.1 ENSMUSG00000138942 (from geneSymbol) uc337hhq.1 uc337hhq.1 
ENSMUST00000350483.1 ENSMUSG00000138943 ENSMUST00000350483.1 ENSMUSG00000138943 (from geneSymbol) uc337hhr.1 uc337hhr.1 
ENSMUST00000350484.1 ENSMUSG00000138944 ENSMUST00000350484.1 ENSMUSG00000138944 (from geneSymbol) uc337hhs.1 uc337hhs.1 
ENSMUST00000350486.1 ENSMUSG00000138945 ENSMUST00000350486.1 ENSMUSG00000138945 (from geneSymbol) uc337hhu.1 uc337hhu.1 
ENSMUST00000350487.1 ENSMUSG00000138946 ENSMUST00000350487.1 ENSMUSG00000138946 (from geneSymbol) uc337hhv.1 uc337hhv.1 
ENSMUST00000350490.1 ENSMUSG00000138947 ENSMUST00000350490.1 ENSMUSG00000138947 (from geneSymbol) uc337hhy.1 uc337hhy.1 
ENSMUST00000350496.1 ENSMUSG00000138948 ENSMUST00000350496.1 ENSMUSG00000138948 (from geneSymbol) uc337hie.1 uc337hie.1 
ENSMUST00000350497.1 ENSMUSG00000138949 ENSMUST00000350497.1 ENSMUSG00000138949 (from geneSymbol) uc337hif.1 uc337hif.1 
ENSMUST00000350498.1 ENSMUSG00000138950 ENSMUST00000350498.1 ENSMUSG00000138950 (from geneSymbol) uc337hig.1 uc337hig.1 
ENSMUST00000350500.1 ENSMUSG00000138951 ENSMUST00000350500.1 ENSMUSG00000138951 (from geneSymbol) uc337hii.1 uc337hii.1 
ENSMUST00000350501.1 ENSMUSG00000138952 ENSMUST00000350501.1 ENSMUSG00000138952 (from geneSymbol) uc337hij.1 uc337hij.1 
ENSMUST00000350502.1 ENSMUSG00000138953 ENSMUST00000350502.1 ENSMUSG00000138953 (from geneSymbol) uc337hik.1 uc337hik.1 
ENSMUST00000350503.1 ENSMUSG00000138954 ENSMUST00000350503.1 ENSMUSG00000138954 (from geneSymbol) uc337hil.1 uc337hil.1 
ENSMUST00000350506.1 ENSMUSG00000138955 ENSMUST00000350506.1 ENSMUSG00000138955 (from geneSymbol) uc337hio.1 uc337hio.1 
ENSMUST00000350507.1 ENSMUSG00000138956 ENSMUST00000350507.1 ENSMUSG00000138956 (from geneSymbol) uc337hip.1 uc337hip.1 
ENSMUST00000350509.1 ENSMUSG00000138957 ENSMUST00000350509.1 ENSMUSG00000138957 (from geneSymbol) uc337hir.1 uc337hir.1 
ENSMUST00000350510.1 ENSMUSG00000138958 ENSMUST00000350510.1 ENSMUSG00000138958 (from geneSymbol) uc337his.1 uc337his.1 
ENSMUST00000350511.1 ENSMUSG00000138959 ENSMUST00000350511.1 ENSMUSG00000138959 (from geneSymbol) uc337hit.1 uc337hit.1 
ENSMUST00000350512.1 ENSMUSG00000138960 ENSMUST00000350512.1 ENSMUSG00000138960 (from geneSymbol) uc337hiu.1 uc337hiu.1 
ENSMUST00000350513.1 ENSMUSG00000138961 ENSMUST00000350513.1 ENSMUSG00000138961 (from geneSymbol) uc337hiv.1 uc337hiv.1 
ENSMUST00000350514.1 ENSMUSG00000138962 ENSMUST00000350514.1 ENSMUSG00000138962 (from geneSymbol) uc337hiw.1 uc337hiw.1 
ENSMUST00000350515.1 Gm57229 ENSMUST00000350515.1 Gm57229 (from geneSymbol) uc337hix.1 uc337hix.1 
ENSMUST00000350516.1 ENSMUSG00000138963 ENSMUST00000350516.1 ENSMUSG00000138963 (from geneSymbol) uc337hiy.1 uc337hiy.1 
ENSMUST00000350519.1 ENSMUSG00000138964 ENSMUST00000350519.1 ENSMUSG00000138964 (from geneSymbol) uc337hjb.1 uc337hjb.1 
ENSMUST00000350520.1 ENSMUSG00000138965 ENSMUST00000350520.1 ENSMUSG00000138965 (from geneSymbol) uc337hjc.1 uc337hjc.1 
ENSMUST00000350521.1 ENSMUSG00000138966 ENSMUST00000350521.1 ENSMUSG00000138966 (from geneSymbol) uc337hjd.1 uc337hjd.1 
ENSMUST00000350522.1 ENSMUSG00000138967 ENSMUST00000350522.1 ENSMUSG00000138967 (from geneSymbol) uc337hje.1 uc337hje.1 
ENSMUST00000350523.1 ENSMUSG00000138968 ENSMUST00000350523.1 ENSMUSG00000138968 (from geneSymbol) uc337hjf.1 uc337hjf.1 
ENSMUST00000350524.1 ENSMUSG00000138969 ENSMUST00000350524.1 ENSMUSG00000138969 (from geneSymbol) uc337hjg.1 uc337hjg.1 
ENSMUST00000350525.1 ENSMUSG00000138970 ENSMUST00000350525.1 ENSMUSG00000138970 (from geneSymbol) uc337hjh.1 uc337hjh.1 
ENSMUST00000350527.1 ENSMUSG00000138971 ENSMUST00000350527.1 ENSMUSG00000138971 (from geneSymbol) uc337hjj.1 uc337hjj.1 
ENSMUST00000350531.1 ENSMUSG00000138972 ENSMUST00000350531.1 ENSMUSG00000138972 (from geneSymbol) uc337hjn.1 uc337hjn.1 
ENSMUST00000350533.1 ENSMUSG00000138973 ENSMUST00000350533.1 ENSMUSG00000138973 (from geneSymbol) uc337hjp.1 uc337hjp.1 
ENSMUST00000350535.1 Gm57033 ENSMUST00000350535.1 Gm57033 (from geneSymbol) uc337hjr.1 uc337hjr.1 
ENSMUST00000350551.1 Ccdc34os ENSMUST00000350551.1 Ccdc34os (from geneSymbol) AK006310 uc337hkh.1 uc337hkh.1 
ENSMUST00000350556.1 Gm29895 ENSMUST00000350556.1 Gm29895 (from geneSymbol) uc337hkm.1 uc337hkm.1 
ENSMUST00000350568.1 ENSMUSG00000138974 ENSMUST00000350568.1 ENSMUSG00000138974 (from geneSymbol) uc337hky.1 uc337hky.1 
ENSMUST00000350569.1 ENSMUSG00000138975 ENSMUST00000350569.1 ENSMUSG00000138975 (from geneSymbol) uc337hkz.1 uc337hkz.1 
ENSMUST00000350570.1 ENSMUSG00000138976 ENSMUST00000350570.1 ENSMUSG00000138976 (from geneSymbol) uc337hla.1 uc337hla.1 
ENSMUST00000350585.1 ENSMUSG00000138977 ENSMUST00000350585.1 ENSMUSG00000138977 (from geneSymbol) uc337hlp.1 uc337hlp.1 
ENSMUST00000350590.1 ENSMUSG00000138978 ENSMUST00000350590.1 ENSMUSG00000138978 (from geneSymbol) uc337hlu.1 uc337hlu.1 
ENSMUST00000350591.1 ENSMUSG00000138979 ENSMUST00000350591.1 ENSMUSG00000138979 (from geneSymbol) uc337hlv.1 uc337hlv.1 
ENSMUST00000350593.1 ENSMUSG00000138980 ENSMUST00000350593.1 ENSMUSG00000138980 (from geneSymbol) uc337hlx.1 uc337hlx.1 
ENSMUST00000350594.1 ENSMUSG00000138981 ENSMUST00000350594.1 ENSMUSG00000138981 (from geneSymbol) uc337hly.1 uc337hly.1 
ENSMUST00000350597.1 Gm15221 ENSMUST00000350597.1 Gm15221 (from geneSymbol) uc337hmb.1 uc337hmb.1 
ENSMUST00000350602.1 ENSMUSG00000138982 ENSMUST00000350602.1 ENSMUSG00000138982 (from geneSymbol) uc337hmg.1 uc337hmg.1 
ENSMUST00000350603.1 ENSMUSG00000138983 ENSMUST00000350603.1 ENSMUSG00000138983 (from geneSymbol) uc337hmh.1 uc337hmh.1 
ENSMUST00000350604.1 ENSMUSG00000138984 ENSMUST00000350604.1 ENSMUSG00000138984 (from geneSymbol) AK076844 uc337hmi.1 uc337hmi.1 
ENSMUST00000350606.1 ENSMUSG00000138985 ENSMUST00000350606.1 ENSMUSG00000138985 (from geneSymbol) uc337hmk.1 uc337hmk.1 
ENSMUST00000350607.1 ENSMUSG00000138986 ENSMUST00000350607.1 ENSMUSG00000138986 (from geneSymbol) uc337hml.1 uc337hml.1 
ENSMUST00000350610.1 ENSMUSG00000138987 ENSMUST00000350610.1 ENSMUSG00000138987 (from geneSymbol) uc337hmo.1 uc337hmo.1 
ENSMUST00000350611.1 ENSMUSG00000138988 ENSMUST00000350611.1 ENSMUSG00000138988 (from geneSymbol) uc337hmp.1 uc337hmp.1 
ENSMUST00000350618.1 ENSMUSG00000138989 ENSMUST00000350618.1 ENSMUSG00000138989 (from geneSymbol) uc337hmw.1 uc337hmw.1 
ENSMUST00000350619.1 ENSMUSG00000138990 ENSMUST00000350619.1 ENSMUSG00000138990 (from geneSymbol) uc337hmx.1 uc337hmx.1 
ENSMUST00000350622.1 ENSMUSG00000138991 ENSMUST00000350622.1 ENSMUSG00000138991 (from geneSymbol) uc337hna.1 uc337hna.1 
ENSMUST00000350624.1 ENSMUSG00000138992 ENSMUST00000350624.1 ENSMUSG00000138992 (from geneSymbol) uc337hnc.1 uc337hnc.1 
ENSMUST00000350626.1 ENSMUSG00000138993 ENSMUST00000350626.1 ENSMUSG00000138993 (from geneSymbol) uc337hne.1 uc337hne.1 
ENSMUST00000350627.1 ENSMUSG00000138994 ENSMUST00000350627.1 ENSMUSG00000138994 (from geneSymbol) AK005929 uc337hnf.1 uc337hnf.1 
ENSMUST00000350629.1 ENSMUSG00000138995 ENSMUST00000350629.1 ENSMUSG00000138995 (from geneSymbol) uc337hnh.1 uc337hnh.1 
ENSMUST00000350633.1 ENSMUSG00000138996 ENSMUST00000350633.1 ENSMUSG00000138996 (from geneSymbol) uc337hnl.1 uc337hnl.1 
ENSMUST00000350634.1 ENSMUSG00000138997 ENSMUST00000350634.1 ENSMUSG00000138997 (from geneSymbol) uc337hnm.1 uc337hnm.1 
ENSMUST00000350635.1 ENSMUSG00000138998 ENSMUST00000350635.1 ENSMUSG00000138998 (from geneSymbol) uc337hnn.1 uc337hnn.1 
ENSMUST00000350636.1 ENSMUSG00000138999 ENSMUST00000350636.1 ENSMUSG00000138999 (from geneSymbol) uc337hno.1 uc337hno.1 
ENSMUST00000350641.1 ENSMUSG00000139000 ENSMUST00000350641.1 ENSMUSG00000139000 (from geneSymbol) uc337hnt.1 uc337hnt.1 
ENSMUST00000350642.1 ENSMUSG00000139001 ENSMUST00000350642.1 ENSMUSG00000139001 (from geneSymbol) uc337hnu.1 uc337hnu.1 
ENSMUST00000350643.1 ENSMUSG00000139002 ENSMUST00000350643.1 ENSMUSG00000139002 (from geneSymbol) uc337hnv.1 uc337hnv.1 
ENSMUST00000350644.1 ENSMUSG00000139003 ENSMUST00000350644.1 ENSMUSG00000139003 (from geneSymbol) uc337hnw.1 uc337hnw.1 
ENSMUST00000350645.1 ENSMUSG00000139004 ENSMUST00000350645.1 ENSMUSG00000139004 (from geneSymbol) uc337hnx.1 uc337hnx.1 
ENSMUST00000350646.1 ENSMUSG00000139005 ENSMUST00000350646.1 ENSMUSG00000139005 (from geneSymbol) uc337hny.1 uc337hny.1 
ENSMUST00000350658.1 1700049E15Rik ENSMUST00000350658.1 1700049E15Rik (from geneSymbol) AK006736 uc337hok.1 uc337hok.1 
ENSMUST00000350661.1 ENSMUSG00000139006 ENSMUST00000350661.1 ENSMUSG00000139006 (from geneSymbol) uc337hon.1 uc337hon.1 
ENSMUST00000350664.1 Gm50399 ENSMUST00000350664.1 Gm50399 (from geneSymbol) uc337hoq.1 uc337hoq.1 
ENSMUST00000350667.1 ENSMUSG00000139007 ENSMUST00000350667.1 ENSMUSG00000139007 (from geneSymbol) uc337hot.1 uc337hot.1 
ENSMUST00000350669.1 ENSMUSG00000139008 ENSMUST00000350669.1 ENSMUSG00000139008 (from geneSymbol) uc337hov.1 uc337hov.1 
ENSMUST00000350671.1 ENSMUSG00000139009 ENSMUST00000350671.1 ENSMUSG00000139009 (from geneSymbol) uc337hox.1 uc337hox.1 
ENSMUST00000350673.1 Gm11418 ENSMUST00000350673.1 predicted gene 11418, transcript variant 2 (from RefSeq NR_167971.1) NR_167971 uc337hoz.1 uc337hoz.1 
ENSMUST00000350677.1 ENSMUSG00000139010 ENSMUST00000350677.1 ENSMUSG00000139010 (from geneSymbol) uc337hpd.1 uc337hpd.1 
ENSMUST00000350678.1 ENSMUSG00000139011 ENSMUST00000350678.1 ENSMUSG00000139011 (from geneSymbol) uc337hpe.1 uc337hpe.1 
ENSMUST00000350680.1 ENSMUSG00000139012 ENSMUST00000350680.1 ENSMUSG00000139012 (from geneSymbol) uc337hpg.1 uc337hpg.1 
ENSMUST00000350681.1 ENSMUSG00000139013 ENSMUST00000350681.1 ENSMUSG00000139013 (from geneSymbol) uc337hph.1 uc337hph.1 
ENSMUST00000350682.1 ENSMUSG00000139014 ENSMUST00000350682.1 ENSMUSG00000139014 (from geneSymbol) uc337hpi.1 uc337hpi.1 
ENSMUST00000350683.1 Gm2629 ENSMUST00000350683.1 Gm2629 (from geneSymbol) AK038705 uc337hpj.1 uc337hpj.1 
ENSMUST00000350704.1 ENSMUSG00000139015 ENSMUST00000350704.1 ENSMUSG00000139015 (from geneSymbol) uc337hqe.1 uc337hqe.1 
ENSMUST00000350713.1 ENSMUSG00000139016 ENSMUST00000350713.1 ENSMUSG00000139016 (from geneSymbol) uc337hqn.1 uc337hqn.1 
ENSMUST00000350714.1 ENSMUSG00000139017 ENSMUST00000350714.1 ENSMUSG00000139017 (from geneSymbol) uc337hqo.1 uc337hqo.1 
ENSMUST00000350715.1 ENSMUSG00000139018 ENSMUST00000350715.1 ENSMUSG00000139018 (from geneSymbol) uc337hqp.1 uc337hqp.1 
ENSMUST00000350716.1 ENSMUSG00000139019 ENSMUST00000350716.1 ENSMUSG00000139019 (from geneSymbol) uc337hqq.1 uc337hqq.1 
ENSMUST00000350718.1 ENSMUSG00000139020 ENSMUST00000350718.1 ENSMUSG00000139020 (from geneSymbol) DQ540134 uc337hqs.1 uc337hqs.1 
ENSMUST00000350719.1 Gm12690 ENSMUST00000350719.1 Gm12690 (from geneSymbol) uc337hqt.1 uc337hqt.1 
ENSMUST00000350725.1 Rbm3os ENSMUST00000350725.1 Rbm3os (from geneSymbol) AK013472 uc337hqz.1 uc337hqz.1 
ENSMUST00000350727.1 ENSMUSG00000139021 ENSMUST00000350727.1 ENSMUSG00000139021 (from geneSymbol) uc337hrb.1 uc337hrb.1 
ENSMUST00000350740.1 1700112M02Rik ENSMUST00000350740.1 1700112M02Rik (from geneSymbol) AK007185 uc337hro.1 uc337hro.1 
ENSMUST00000350781.1 ENSMUSG00000139022 ENSMUST00000350781.1 ENSMUSG00000139022 (from geneSymbol) BC063063 uc337htd.1 uc337htd.1 
ENSMUST00000350782.1 ENSMUSG00000139023 ENSMUST00000350782.1 ENSMUSG00000139023 (from geneSymbol) uc337hte.1 uc337hte.1 
ENSMUST00000350783.1 ENSMUSG00000139024 ENSMUST00000350783.1 ENSMUSG00000139024 (from geneSymbol) uc337htf.1 uc337htf.1 
ENSMUST00000350785.1 ENSMUSG00000139026 ENSMUST00000350785.1 ENSMUSG00000139026 (from geneSymbol) uc337htg.1 uc337htg.1 
ENSMUST00000350789.1 ENSMUSG00000139028 ENSMUST00000350789.1 ENSMUSG00000139028 (from geneSymbol) uc337htj.1 uc337htj.1 
ENSMUST00000350803.1 ENSMUSG00000139029 ENSMUST00000350803.1 ENSMUSG00000139029 (from geneSymbol) uc337htx.1 uc337htx.1 
ENSMUST00000350804.1 ENSMUSG00000139030 ENSMUST00000350804.1 ENSMUSG00000139030 (from geneSymbol) uc337hty.1 uc337hty.1 
ENSMUST00000350805.1 ENSMUSG00000139031 ENSMUST00000350805.1 ENSMUSG00000139031 (from geneSymbol) uc337htz.1 uc337htz.1 
ENSMUST00000350809.1 4930455G09Rik ENSMUST00000350809.1 4930455G09Rik (from geneSymbol) KY468028 uc337hud.1 uc337hud.1 
ENSMUST00000350838.1 ENSMUSG00000139032 ENSMUST00000350838.1 ENSMUSG00000139032 (from geneSymbol) uc337hvf.1 uc337hvf.1 
ENSMUST00000350839.1 ENSMUSG00000139033 ENSMUST00000350839.1 ENSMUSG00000139033 (from geneSymbol) uc337hvg.1 uc337hvg.1 
ENSMUST00000350841.1 ENSMUSG00000139034 ENSMUST00000350841.1 ENSMUSG00000139034 (from geneSymbol) uc337hvi.1 uc337hvi.1 
ENSMUST00000350843.1 ENSMUSG00000139035 ENSMUST00000350843.1 ENSMUSG00000139035 (from geneSymbol) uc337hvk.1 uc337hvk.1 
ENSMUST00000350847.1 ENSMUSG00000139036 ENSMUST00000350847.1 ENSMUSG00000139036 (from geneSymbol) uc337hvo.1 uc337hvo.1 
ENSMUST00000350848.1 ENSMUSG00000139037 ENSMUST00000350848.1 ENSMUSG00000139037 (from geneSymbol) uc337hvp.1 uc337hvp.1 
ENSMUST00000350850.1 ENSMUSG00000139038 ENSMUST00000350850.1 ENSMUSG00000139038 (from geneSymbol) AK006317 uc337hvr.1 uc337hvr.1 
ENSMUST00000350855.1 ENSMUSG00000139039 ENSMUST00000350855.1 ENSMUSG00000139039 (from geneSymbol) uc337hvw.1 uc337hvw.1 
ENSMUST00000350856.1 ENSMUSG00000139040 ENSMUST00000350856.1 ENSMUSG00000139040 (from geneSymbol) uc337hvx.1 uc337hvx.1 
ENSMUST00000350857.1 Gm10830 ENSMUST00000350857.1 Gm10830 (from geneSymbol) uc337hvy.1 uc337hvy.1 
ENSMUST00000350865.1 Gm15762 ENSMUST00000350865.1 Gm15762 (from geneSymbol) AK076842 uc337hwg.1 uc337hwg.1 
ENSMUST00000350869.1 ENSMUSG00000139041 ENSMUST00000350869.1 ENSMUSG00000139041 (from geneSymbol) uc337hwk.1 uc337hwk.1 
ENSMUST00000350870.1 ENSMUSG00000139042 ENSMUST00000350870.1 ENSMUSG00000139042 (from geneSymbol) uc337hwl.1 uc337hwl.1 
ENSMUST00000350871.1 ENSMUSG00000139043 ENSMUST00000350871.1 ENSMUSG00000139043 (from geneSymbol) uc337hwm.1 uc337hwm.1 
ENSMUST00000350872.1 ENSMUSG00000139044 ENSMUST00000350872.1 ENSMUSG00000139044 (from geneSymbol) uc337hwn.1 uc337hwn.1 
ENSMUST00000350873.1 ENSMUSG00000139045 ENSMUST00000350873.1 ENSMUSG00000139045 (from geneSymbol) uc337hwo.1 uc337hwo.1 
ENSMUST00000350874.1 Gm33033 ENSMUST00000350874.1 Gm33033 (from geneSymbol) uc337hwp.1 uc337hwp.1 
ENSMUST00000350882.1 Gm32800 ENSMUST00000350882.1 Gm32800 (from geneSymbol) uc337hwx.1 uc337hwx.1 
ENSMUST00000350885.1 ENSMUSG00000139046 ENSMUST00000350885.1 ENSMUSG00000139046 (from geneSymbol) uc337hxa.1 uc337hxa.1 
ENSMUST00000350886.1 ENSMUSG00000139047 ENSMUST00000350886.1 ENSMUSG00000139047 (from geneSymbol) uc337hxb.1 uc337hxb.1 
ENSMUST00000350887.1 ENSMUSG00000139048 ENSMUST00000350887.1 ENSMUSG00000139048 (from geneSymbol) uc337hxc.1 uc337hxc.1 
ENSMUST00000350888.1 ENSMUSG00000139049 ENSMUST00000350888.1 ENSMUSG00000139049 (from geneSymbol) uc337hxd.1 uc337hxd.1 
ENSMUST00000350889.1 ENSMUSG00000139050 ENSMUST00000350889.1 ENSMUSG00000139050 (from geneSymbol) uc337hxe.1 uc337hxe.1 
ENSMUST00000350890.1 ENSMUSG00000139051 ENSMUST00000350890.1 ENSMUSG00000139051 (from geneSymbol) uc337hxf.1 uc337hxf.1 
ENSMUST00000350894.1 ENSMUSG00000139052 ENSMUST00000350894.1 ENSMUSG00000139052 (from geneSymbol) uc337hxj.1 uc337hxj.1 
ENSMUST00000350896.1 ENSMUSG00000139053 ENSMUST00000350896.1 ENSMUSG00000139053 (from geneSymbol) uc337hxl.1 uc337hxl.1 
ENSMUST00000350897.1 ENSMUSG00000139054 ENSMUST00000350897.1 ENSMUSG00000139054 (from geneSymbol) uc337hxm.1 uc337hxm.1 
ENSMUST00000350898.1 ENSMUSG00000139055 ENSMUST00000350898.1 ENSMUSG00000139055 (from geneSymbol) uc337hxn.1 uc337hxn.1 
ENSMUST00000350899.1 ENSMUSG00000139056 ENSMUST00000350899.1 ENSMUSG00000139056 (from geneSymbol) uc337hxo.1 uc337hxo.1 
ENSMUST00000350900.1 ENSMUSG00000139057 ENSMUST00000350900.1 ENSMUSG00000139057 (from geneSymbol) uc337hxp.1 uc337hxp.1 
ENSMUST00000350901.1 ENSMUSG00000139058 ENSMUST00000350901.1 ENSMUSG00000139058 (from geneSymbol) AK154187 uc337hxq.1 uc337hxq.1 
ENSMUST00000350903.1 ENSMUSG00000139059 ENSMUST00000350903.1 ENSMUSG00000139059 (from geneSymbol) uc337hxs.1 uc337hxs.1 
ENSMUST00000350911.1 ENSMUSG00000139060 ENSMUST00000350911.1 ENSMUSG00000139060 (from geneSymbol) uc337hya.1 uc337hya.1 
ENSMUST00000350920.1 ENSMUSG00000121853 ENSMUST00000350920.1 ENSMUSG00000121853 (from geneSymbol) uc337hyj.1 uc337hyj.1 
ENSMUST00000350928.1 ENSMUSG00000139061 ENSMUST00000350928.1 ENSMUSG00000139061 (from geneSymbol) uc337hyr.1 uc337hyr.1 
ENSMUST00000350933.1 ENSMUSG00000139062 ENSMUST00000350933.1 ENSMUSG00000139062 (from geneSymbol) uc337hyw.1 uc337hyw.1 
ENSMUST00000350945.1 ENSMUSG00000139063 ENSMUST00000350945.1 ENSMUSG00000139063 (from geneSymbol) uc337hzi.1 uc337hzi.1 
ENSMUST00000350947.1 ENSMUSG00000139064 ENSMUST00000350947.1 ENSMUSG00000139064 (from geneSymbol) uc337hzk.1 uc337hzk.1 
ENSMUST00000350954.1 ENSMUSG00000139065 ENSMUST00000350954.1 ENSMUSG00000139065 (from geneSymbol) uc337hzr.1 uc337hzr.1 
ENSMUST00000350955.1 ENSMUSG00000139066 ENSMUST00000350955.1 ENSMUSG00000139066 (from geneSymbol) uc337hzs.1 uc337hzs.1 
ENSMUST00000350956.1 ENSMUSG00000139067 ENSMUST00000350956.1 ENSMUSG00000139067 (from geneSymbol) uc337hzt.1 uc337hzt.1 
ENSMUST00000350959.1 ENSMUSG00000139068 ENSMUST00000350959.1 ENSMUSG00000139068 (from geneSymbol) uc337hzw.1 uc337hzw.1 
ENSMUST00000350960.1 ENSMUSG00000139069 ENSMUST00000350960.1 ENSMUSG00000139069 (from geneSymbol) uc337hzx.1 uc337hzx.1 
ENSMUST00000350961.1 ENSMUSG00000139070 ENSMUST00000350961.1 ENSMUSG00000139070 (from geneSymbol) uc337hzy.1 uc337hzy.1 
ENSMUST00000350963.1 ENSMUSG00000139071 ENSMUST00000350963.1 ENSMUSG00000139071 (from geneSymbol) uc337iaa.1 uc337iaa.1 
ENSMUST00000350964.1 ENSMUSG00000139072 ENSMUST00000350964.1 ENSMUSG00000139072 (from geneSymbol) uc337iab.1 uc337iab.1 
ENSMUST00000350965.1 ENSMUSG00000139073 ENSMUST00000350965.1 ENSMUSG00000139073 (from geneSymbol) FJ654127 uc337iac.1 uc337iac.1 
ENSMUST00000350967.1 Gm29456 ENSMUST00000350967.1 Gm29456 (from geneSymbol) uc337iae.1 uc337iae.1 
ENSMUST00000350979.1 ENSMUSG00000139074 ENSMUST00000350979.1 ENSMUSG00000139074 (from geneSymbol) uc337iaq.1 uc337iaq.1 
ENSMUST00000350980.1 ENSMUSG00000139075 ENSMUST00000350980.1 ENSMUSG00000139075 (from geneSymbol) uc337iar.1 uc337iar.1 
ENSMUST00000350981.1 ENSMUSG00000139076 ENSMUST00000350981.1 ENSMUSG00000139076 (from geneSymbol) uc337ias.1 uc337ias.1 
ENSMUST00000350983.1 ENSMUSG00000139077 ENSMUST00000350983.1 ENSMUSG00000139077 (from geneSymbol) uc337iau.1 uc337iau.1 
ENSMUST00000350984.1 ENSMUSG00000139078 ENSMUST00000350984.1 ENSMUSG00000139078 (from geneSymbol) uc337iav.1 uc337iav.1 
ENSMUST00000350986.1 ENSMUSG00000139079 ENSMUST00000350986.1 ENSMUSG00000139079 (from geneSymbol) uc337iax.1 uc337iax.1 
ENSMUST00000350989.1 ENSMUSG00000139080 ENSMUST00000350989.1 ENSMUSG00000139080 (from geneSymbol) uc337iba.1 uc337iba.1 
ENSMUST00000350990.1 ENSMUSG00000139081 ENSMUST00000350990.1 ENSMUSG00000139081 (from geneSymbol) uc337ibb.1 uc337ibb.1 
ENSMUST00000350995.1 Gm49477 ENSMUST00000350995.1 Gm49477 (from geneSymbol) AK084656 uc337ibg.1 uc337ibg.1 
ENSMUST00000350998.1 ENSMUSG00000139082 ENSMUST00000350998.1 ENSMUSG00000139082 (from geneSymbol) uc337ibj.1 uc337ibj.1 
ENSMUST00000351005.1 ENSMUSG00000139083 ENSMUST00000351005.1 ENSMUSG00000139083 (from geneSymbol) uc337ibq.1 uc337ibq.1 
ENSMUST00000351006.1 ENSMUSG00000139084 ENSMUST00000351006.1 ENSMUSG00000139084 (from geneSymbol) uc337ibr.1 uc337ibr.1 
ENSMUST00000351022.1 ENSMUSG00000139085 ENSMUST00000351022.1 ENSMUSG00000139085 (from geneSymbol) uc337ich.1 uc337ich.1 
ENSMUST00000351028.1 ENSMUSG00000139086 ENSMUST00000351028.1 ENSMUSG00000139086 (from geneSymbol) uc337icn.1 uc337icn.1 
ENSMUST00000351029.1 ENSMUSG00000139087 ENSMUST00000351029.1 ENSMUSG00000139087 (from geneSymbol) uc337ico.1 uc337ico.1 
ENSMUST00000351031.1 ENSMUSG00000139088 ENSMUST00000351031.1 ENSMUSG00000139088 (from geneSymbol) uc337icq.1 uc337icq.1 
ENSMUST00000351033.1 ENSMUSG00000139089 ENSMUST00000351033.1 ENSMUSG00000139089 (from geneSymbol) uc337ics.1 uc337ics.1 
ENSMUST00000351068.1 ENSMUSG00000139090 ENSMUST00000351068.1 ENSMUSG00000139090 (from geneSymbol) uc337iea.1 uc337iea.1 
ENSMUST00000351085.1 ENSMUSG00000139091 ENSMUST00000351085.1 ENSMUSG00000139091 (from geneSymbol) uc337ier.1 uc337ier.1 
ENSMUST00000351086.1 ENSMUSG00000139092 ENSMUST00000351086.1 ENSMUSG00000139092 (from geneSymbol) uc337ies.1 uc337ies.1 
ENSMUST00000351087.1 ENSMUSG00000139093 ENSMUST00000351087.1 ENSMUSG00000139093 (from geneSymbol) uc337iet.1 uc337iet.1 
ENSMUST00000351091.1 ENSMUSG00000139094 ENSMUST00000351091.1 ENSMUSG00000139094 (from geneSymbol) uc337iex.1 uc337iex.1 
ENSMUST00000351093.1 ENSMUSG00000139095 ENSMUST00000351093.1 ENSMUSG00000139095 (from geneSymbol) uc337iez.1 uc337iez.1 
ENSMUST00000351095.1 ENSMUSG00000139096 ENSMUST00000351095.1 ENSMUSG00000139096 (from geneSymbol) uc337ifb.1 uc337ifb.1 
ENSMUST00000351102.1 ENSMUSG00000139097 ENSMUST00000351102.1 ENSMUSG00000139097 (from geneSymbol) uc337ifi.1 uc337ifi.1 
ENSMUST00000351105.1 ENSMUSG00000139098 ENSMUST00000351105.1 ENSMUSG00000139098 (from geneSymbol) uc337ifl.1 uc337ifl.1 
ENSMUST00000351106.1 ENSMUSG00000139099 ENSMUST00000351106.1 ENSMUSG00000139099 (from geneSymbol) uc337ifm.1 uc337ifm.1 
ENSMUST00000351107.1 Gm57327 ENSMUST00000351107.1 Gm57327 (from geneSymbol) uc337ifn.1 uc337ifn.1 
ENSMUST00000351112.1 ENSMUSG00000139100 ENSMUST00000351112.1 ENSMUSG00000139100 (from geneSymbol) uc337ifs.1 uc337ifs.1 
ENSMUST00000351113.1 ENSMUSG00000139101 ENSMUST00000351113.1 ENSMUSG00000139101 (from geneSymbol) uc337ift.1 uc337ift.1 
ENSMUST00000351115.1 ENSMUSG00000139102 ENSMUST00000351115.1 ENSMUSG00000139102 (from geneSymbol) uc337ifv.1 uc337ifv.1 
ENSMUST00000351120.1 ENSMUSG00000139103 ENSMUST00000351120.1 ENSMUSG00000139103 (from geneSymbol) uc337iga.1 uc337iga.1 
ENSMUST00000351124.1 ENSMUSG00000139104 ENSMUST00000351124.1 ENSMUSG00000139104 (from geneSymbol) uc337ige.1 uc337ige.1 
ENSMUST00000351129.1 A230083G16Rik ENSMUST00000351129.1 A230083G16Rik (from geneSymbol) AK038996 uc337igj.1 uc337igj.1 
ENSMUST00000351138.1 ENSMUSG00000139105 ENSMUST00000351138.1 ENSMUSG00000139105 (from geneSymbol) uc337igs.1 uc337igs.1 
ENSMUST00000351139.1 ENSMUSG00000139106 ENSMUST00000351139.1 ENSMUSG00000139106 (from geneSymbol) uc337igt.1 uc337igt.1 
ENSMUST00000351140.1 ENSMUSG00000139107 ENSMUST00000351140.1 ENSMUSG00000139107 (from geneSymbol) uc337igu.1 uc337igu.1 
ENSMUST00000351142.1 ENSMUSG00000139108 ENSMUST00000351142.1 ENSMUSG00000139108 (from geneSymbol) uc337igw.1 uc337igw.1 
ENSMUST00000351144.1 ENSMUSG00000139109 ENSMUST00000351144.1 ENSMUSG00000139109 (from geneSymbol) uc337igy.1 uc337igy.1 
ENSMUST00000351173.1 ENSMUSG00000139110 ENSMUST00000351173.1 ENSMUSG00000139110 (from geneSymbol) uc337iib.1 uc337iib.1 
ENSMUST00000351176.1 Gm30849 ENSMUST00000351176.1 Gm30849 (from geneSymbol) uc337iie.1 uc337iie.1 
ENSMUST00000351184.1 ENSMUSG00000139111 ENSMUST00000351184.1 ENSMUSG00000139111 (from geneSymbol) uc337iim.1 uc337iim.1 
ENSMUST00000351185.1 ENSMUSG00000139112 ENSMUST00000351185.1 ENSMUSG00000139112 (from geneSymbol) uc337iin.1 uc337iin.1 
ENSMUST00000351187.1 Gm44127 ENSMUST00000351187.1 Gm44127 (from geneSymbol) uc337iip.1 uc337iip.1 
ENSMUST00000351197.1 ENSMUSG00000139113 ENSMUST00000351197.1 ENSMUSG00000139113 (from geneSymbol) uc337iiy.1 uc337iiy.1 
ENSMUST00000351212.1 ENSMUSG00000139114 ENSMUST00000351212.1 ENSMUSG00000139114 (from geneSymbol) uc337ijn.1 uc337ijn.1 
ENSMUST00000351213.1 Gm32014 ENSMUST00000351213.1 Gm32014 (from geneSymbol) AK137684 uc337ijo.1 uc337ijo.1 
ENSMUST00000351218.1 ENSMUSG00000139115 ENSMUST00000351218.1 ENSMUSG00000139115 (from geneSymbol) uc337ijt.1 uc337ijt.1 
ENSMUST00000351219.1 ENSMUSG00000139116 ENSMUST00000351219.1 ENSMUSG00000139116 (from geneSymbol) uc337iju.1 uc337iju.1 
ENSMUST00000351222.1 ENSMUSG00000139117 ENSMUST00000351222.1 ENSMUSG00000139117 (from geneSymbol) uc337ijx.1 uc337ijx.1 
ENSMUST00000351223.1 ENSMUSG00000139118 ENSMUST00000351223.1 ENSMUSG00000139118 (from geneSymbol) uc337ijy.1 uc337ijy.1 
ENSMUST00000351224.1 ENSMUSG00000139119 ENSMUST00000351224.1 ENSMUSG00000139119 (from geneSymbol) uc337ijz.1 uc337ijz.1 
ENSMUST00000351225.1 ENSMUSG00000139120 ENSMUST00000351225.1 ENSMUSG00000139120 (from geneSymbol) uc337ika.1 uc337ika.1 
ENSMUST00000351226.1 ENSMUSG00000139121 ENSMUST00000351226.1 ENSMUSG00000139121 (from geneSymbol) uc337ikb.1 uc337ikb.1 
ENSMUST00000351231.1 ENSMUSG00000139122 ENSMUST00000351231.1 ENSMUSG00000139122 (from geneSymbol) uc337ikg.1 uc337ikg.1 
ENSMUST00000351232.1 ENSMUSG00000139123 ENSMUST00000351232.1 ENSMUSG00000139123 (from geneSymbol) uc337ikh.1 uc337ikh.1 
ENSMUST00000351233.1 ENSMUSG00000139124 ENSMUST00000351233.1 ENSMUSG00000139124 (from geneSymbol) uc337iki.1 uc337iki.1 
ENSMUST00000351235.1 ENSMUSG00000139125 ENSMUST00000351235.1 ENSMUSG00000139125 (from geneSymbol) uc337ikk.1 uc337ikk.1 
ENSMUST00000351236.1 ENSMUSG00000139126 ENSMUST00000351236.1 ENSMUSG00000139126 (from geneSymbol) uc337ikl.1 uc337ikl.1 
ENSMUST00000351240.1 Gm14319 ENSMUST00000351240.1 Gm14319 (from geneSymbol) uc337ikp.1 uc337ikp.1 
ENSMUST00000351254.1 ENSMUSG00000139127 ENSMUST00000351254.1 ENSMUSG00000139127 (from geneSymbol) uc337ild.1 uc337ild.1 
ENSMUST00000351255.1 ENSMUSG00000139128 ENSMUST00000351255.1 ENSMUSG00000139128 (from geneSymbol) uc337ile.1 uc337ile.1 
ENSMUST00000351256.1 ENSMUSG00000139129 ENSMUST00000351256.1 ENSMUSG00000139129 (from geneSymbol) uc337ilf.1 uc337ilf.1 
ENSMUST00000351266.1 4930449C09Rik ENSMUST00000351266.1 4930449C09Rik (from geneSymbol) uc337ilp.1 uc337ilp.1 
ENSMUST00000351276.1 Gm56494 ENSMUST00000351276.1 Gm56494 (from geneSymbol) uc337ilz.1 uc337ilz.1 
ENSMUST00000351282.1 ENSMUSG00000139130 ENSMUST00000351282.1 ENSMUSG00000139130 (from geneSymbol) uc337imf.1 uc337imf.1 
ENSMUST00000351284.1 ENSMUSG00000139131 ENSMUST00000351284.1 ENSMUSG00000139131 (from geneSymbol) uc337imh.1 uc337imh.1 
ENSMUST00000351289.1 ENSMUSG00000139132 ENSMUST00000351289.1 ENSMUSG00000139132 (from geneSymbol) uc337imm.1 uc337imm.1 
ENSMUST00000351300.1 ENSMUSG00000139133 ENSMUST00000351300.1 ENSMUSG00000139133 (from geneSymbol) uc337imx.1 uc337imx.1 
ENSMUST00000351309.1 Smok4a ENSMUST00000351309.1 Smok4a (from geneSymbol) AK029728 uc337ing.1 uc337ing.1 
ENSMUST00000351310.1 ENSMUSG00000139134 ENSMUST00000351310.1 ENSMUSG00000139134 (from geneSymbol) uc337inh.1 uc337inh.1 
ENSMUST00000351312.1 ENSMUSG00000139135 ENSMUST00000351312.1 ENSMUSG00000139135 (from geneSymbol) uc337inj.1 uc337inj.1 
ENSMUST00000351313.1 ENSMUSG00000139136 ENSMUST00000351313.1 ENSMUSG00000139136 (from geneSymbol) uc337ink.1 uc337ink.1 
ENSMUST00000351314.1 Gm31752 ENSMUST00000351314.1 Gm31752 (from geneSymbol) AK076902 uc337inl.1 uc337inl.1 
ENSMUST00000351353.1 ENSMUSG00000139137 ENSMUST00000351353.1 ENSMUSG00000139137 (from geneSymbol) uc337ioy.1 uc337ioy.1 
ENSMUST00000351356.1 ENSMUSG00000139138 ENSMUST00000351356.1 ENSMUSG00000139138 (from geneSymbol) uc337ipb.1 uc337ipb.1 
ENSMUST00000351358.1 ENSMUSG00000139139 ENSMUST00000351358.1 ENSMUSG00000139139 (from geneSymbol) uc337ipd.1 uc337ipd.1 
ENSMUST00000351360.1 ENSMUSG00000139140 ENSMUST00000351360.1 ENSMUSG00000139140 (from geneSymbol) uc337ipf.1 uc337ipf.1 
ENSMUST00000351363.1 ENSMUSG00000139141 ENSMUST00000351363.1 ENSMUSG00000139141 (from geneSymbol) uc337ipi.1 uc337ipi.1 
ENSMUST00000351366.1 ENSMUSG00000139142 ENSMUST00000351366.1 ENSMUSG00000139142 (from geneSymbol) uc337ipl.1 uc337ipl.1 
ENSMUST00000351367.1 ENSMUSG00000139143 ENSMUST00000351367.1 ENSMUSG00000139143 (from geneSymbol) uc337ipm.1 uc337ipm.1 
ENSMUST00000351369.1 ENSMUSG00000139144 ENSMUST00000351369.1 ENSMUSG00000139144 (from geneSymbol) uc337ipo.1 uc337ipo.1 
ENSMUST00000351374.1 ENSMUSG00000139145 ENSMUST00000351374.1 ENSMUSG00000139145 (from geneSymbol) uc337ipt.1 uc337ipt.1 
ENSMUST00000351376.1 ENSMUSG00000139146 ENSMUST00000351376.1 ENSMUSG00000139146 (from geneSymbol) uc337ipv.1 uc337ipv.1 
ENSMUST00000351393.1 Gm41071 ENSMUST00000351393.1 Gm41071 (from geneSymbol) uc337iql.1 uc337iql.1 
ENSMUST00000351410.1 ENSMUSG00000139147 ENSMUST00000351410.1 ENSMUSG00000139147 (from geneSymbol) uc337iqq.1 uc337iqq.1 
ENSMUST00000351412.1 ENSMUSG00000139148 ENSMUST00000351412.1 ENSMUSG00000139148 (from geneSymbol) uc337iqs.1 uc337iqs.1 
ENSMUST00000351415.1 Gm19990 ENSMUST00000351415.1 Gm19990 (from geneSymbol) AK053248 uc337iqv.1 uc337iqv.1 
ENSMUST00000351433.1 Gm35822 ENSMUST00000351433.1 Gm35822 (from geneSymbol) uc337irn.1 uc337irn.1 
ENSMUST00000351449.1 ENSMUSG00000139149 ENSMUST00000351449.1 ENSMUSG00000139149 (from geneSymbol) uc337isd.1 uc337isd.1 
ENSMUST00000351450.1 ENSMUSG00000139150 ENSMUST00000351450.1 ENSMUSG00000139150 (from geneSymbol) uc337ise.1 uc337ise.1 
ENSMUST00000351453.1 ENSMUSG00000139151 ENSMUST00000351453.1 ENSMUSG00000139151 (from geneSymbol) uc337ish.1 uc337ish.1 
ENSMUST00000351454.1 ENSMUSG00000139152 ENSMUST00000351454.1 ENSMUSG00000139152 (from geneSymbol) uc337isi.1 uc337isi.1 
ENSMUST00000351458.1 ENSMUSG00000139153 ENSMUST00000351458.1 ENSMUSG00000139153 (from geneSymbol) uc337ism.1 uc337ism.1 
ENSMUST00000351462.1 Ptprjos1 ENSMUST00000351462.1 Ptprjos1 (from geneSymbol) AK016880 uc337isq.1 uc337isq.1 
ENSMUST00000351468.1 ENSMUSG00000139154 ENSMUST00000351468.1 ENSMUSG00000139154 (from geneSymbol) uc337isw.1 uc337isw.1 
ENSMUST00000351469.1 1700040D17Rik ENSMUST00000351469.1 1700040D17Rik (from geneSymbol) AK008231 uc337isx.1 uc337isx.1 
ENSMUST00000351473.1 Gm14089 ENSMUST00000351473.1 Gm14089 (from geneSymbol) uc337itb.1 uc337itb.1 
ENSMUST00000351506.1 ENSMUSG00000139155 ENSMUST00000351506.1 ENSMUSG00000139155 (from geneSymbol) uc337iui.1 uc337iui.1 
ENSMUST00000351510.1 ENSMUSG00000139156 ENSMUST00000351510.1 ENSMUSG00000139156 (from geneSymbol) uc337ium.1 uc337ium.1 
ENSMUST00000351514.1 4732465J04Rik ENSMUST00000351514.1 predicted gene, 33377, transcript variant 4 (from RefSeq NR_176636.1) NR_176636 uc337iuq.1 uc337iuq.1 
ENSMUST00000351523.1 ENSMUSG00000139157 ENSMUST00000351523.1 ENSMUSG00000139157 (from geneSymbol) uc337iuz.1 uc337iuz.1 
ENSMUST00000351524.1 ENSMUSG00000139158 ENSMUST00000351524.1 ENSMUSG00000139158 (from geneSymbol) uc337iva.1 uc337iva.1 
ENSMUST00000351530.1 ENSMUSG00000139159 ENSMUST00000351530.1 ENSMUSG00000139159 (from geneSymbol) uc337ivc.1 uc337ivc.1 
ENSMUST00000351551.1 ENSMUSG00000139160 ENSMUST00000351551.1 ENSMUSG00000139160 (from geneSymbol) uc337ivx.1 uc337ivx.1 
ENSMUST00000351556.1 E330017L17Rik ENSMUST00000351556.1 E330017L17Rik (from geneSymbol) AK054344 uc337iwc.1 uc337iwc.1 
ENSMUST00000351559.1 ENSMUSG00000139161 ENSMUST00000351559.1 ENSMUSG00000139161 (from geneSymbol) uc337iwf.1 uc337iwf.1 
ENSMUST00000351561.1 Gm47391 ENSMUST00000351561.1 Gm47391 (from geneSymbol) uc337iwh.1 uc337iwh.1 
ENSMUST00000351564.1 ENSMUSG00000139162 ENSMUST00000351564.1 ENSMUSG00000139162 (from geneSymbol) uc337iwk.1 uc337iwk.1 
ENSMUST00000351568.1 ENSMUSG00000139163 ENSMUST00000351568.1 ENSMUSG00000139163 (from geneSymbol) uc337iwo.1 uc337iwo.1 
ENSMUST00000351570.1 ENSMUSG00000139164 ENSMUST00000351570.1 ENSMUSG00000139164 (from geneSymbol) uc337iwq.1 uc337iwq.1 
ENSMUST00000351571.1 ENSMUSG00000139165 ENSMUST00000351571.1 ENSMUSG00000139165 (from geneSymbol) uc337iwr.1 uc337iwr.1 
ENSMUST00000351572.1 ENSMUSG00000139166 ENSMUST00000351572.1 ENSMUSG00000139166 (from geneSymbol) uc337iws.1 uc337iws.1 
ENSMUST00000351573.1 ENSMUSG00000139167 ENSMUST00000351573.1 ENSMUSG00000139167 (from geneSymbol) uc337iwt.1 uc337iwt.1 
ENSMUST00000351574.1 ENSMUSG00000139168 ENSMUST00000351574.1 ENSMUSG00000139168 (from geneSymbol) uc337iwu.1 uc337iwu.1 
ENSMUST00000351575.1 ENSMUSG00000139169 ENSMUST00000351575.1 ENSMUSG00000139169 (from geneSymbol) uc337iwv.1 uc337iwv.1 
ENSMUST00000351577.1 ENSMUSG00000139170 ENSMUST00000351577.1 ENSMUSG00000139170 (from geneSymbol) uc337iwx.1 uc337iwx.1 
ENSMUST00000351578.1 ENSMUSG00000139171 ENSMUST00000351578.1 ENSMUSG00000139171 (from geneSymbol) uc337iwy.1 uc337iwy.1 
ENSMUST00000351587.1 9530026F06Rik ENSMUST00000351587.1 9530026F06Rik (from geneSymbol) AK020574 uc337ixh.1 uc337ixh.1 
ENSMUST00000351598.1 ENSMUSG00000139172 ENSMUST00000351598.1 ENSMUSG00000139172 (from geneSymbol) uc337ixs.1 uc337ixs.1 
ENSMUST00000351603.1 Gm48447 ENSMUST00000351603.1 Gm48447 (from geneSymbol) uc337ixx.1 uc337ixx.1 
ENSMUST00000351606.1 ENSMUSG00000139173 ENSMUST00000351606.1 ENSMUSG00000139173 (from geneSymbol) uc337iya.1 uc337iya.1 
ENSMUST00000351607.1 ENSMUSG00000139174 ENSMUST00000351607.1 ENSMUSG00000139174 (from geneSymbol) uc337iyb.1 uc337iyb.1 
ENSMUST00000351613.1 ENSMUSG00000139175 ENSMUST00000351613.1 ENSMUSG00000139175 (from geneSymbol) uc337iyh.1 uc337iyh.1 
ENSMUST00000351619.1 ENSMUSG00000139176 ENSMUST00000351619.1 ENSMUSG00000139176 (from geneSymbol) uc337iyn.1 uc337iyn.1 
ENSMUST00000351621.1 ENSMUSG00000139177 ENSMUST00000351621.1 ENSMUSG00000139177 (from geneSymbol) uc337iyp.1 uc337iyp.1 
ENSMUST00000351623.1 ENSMUSG00000139178 ENSMUST00000351623.1 ENSMUSG00000139178 (from geneSymbol) uc337iyr.1 uc337iyr.1 
ENSMUST00000351625.1 E330011O21Rik ENSMUST00000351625.1 E330011O21Rik (from geneSymbol) AK087725 uc337iys.1 uc337iys.1 
ENSMUST00000351724.1 ENSMUSG00000139180 ENSMUST00000351724.1 ENSMUSG00000139180 (from geneSymbol) uc337jcm.1 uc337jcm.1 
ENSMUST00000351725.1 ENSMUSG00000139181 ENSMUST00000351725.1 ENSMUSG00000139181 (from geneSymbol) uc337jcn.1 uc337jcn.1 
ENSMUST00000351726.1 ENSMUSG00000139182 ENSMUST00000351726.1 ENSMUSG00000139182 (from geneSymbol) uc337jco.1 uc337jco.1 
ENSMUST00000351730.1 ENSMUSG00000121497 ENSMUST00000351730.1 ENSMUSG00000121497 (from geneSymbol) BC061166 uc337jcs.1 uc337jcs.1 
ENSMUST00000351736.1 ENSMUSG00000139183 ENSMUST00000351736.1 ENSMUSG00000139183 (from geneSymbol) uc337jcy.1 uc337jcy.1 
ENSMUST00000351741.1 ENSMUSG00000139184 ENSMUST00000351741.1 ENSMUSG00000139184 (from geneSymbol) uc337jdd.1 uc337jdd.1 
ENSMUST00000351743.1 ENSMUSG00000139185 ENSMUST00000351743.1 ENSMUSG00000139185 (from geneSymbol) uc337jdf.1 uc337jdf.1 
ENSMUST00000351749.1 ENSMUSG00000139186 ENSMUST00000351749.1 ENSMUSG00000139186 (from geneSymbol) uc337jdl.1 uc337jdl.1 
ENSMUST00000351750.1 ENSMUSG00000139187 ENSMUST00000351750.1 ENSMUSG00000139187 (from geneSymbol) uc337jdm.1 uc337jdm.1 
ENSMUST00000351751.1 ENSMUSG00000139188 ENSMUST00000351751.1 ENSMUSG00000139188 (from geneSymbol) uc337jdn.1 uc337jdn.1 
ENSMUST00000351752.1 ENSMUSG00000139189 ENSMUST00000351752.1 ENSMUSG00000139189 (from geneSymbol) uc337jdo.1 uc337jdo.1 
ENSMUST00000351754.1 ENSMUSG00000139190 ENSMUST00000351754.1 ENSMUSG00000139190 (from geneSymbol) uc337jdq.1 uc337jdq.1 
ENSMUST00000351757.1 ENSMUSG00000139191 ENSMUST00000351757.1 ENSMUSG00000139191 (from geneSymbol) uc337jdt.1 uc337jdt.1 
ENSMUST00000351758.1 ENSMUSG00000139192 ENSMUST00000351758.1 ENSMUSG00000139192 (from geneSymbol) uc337jdu.1 uc337jdu.1 
ENSMUST00000351759.1 ENSMUSG00000139193 ENSMUST00000351759.1 ENSMUSG00000139193 (from geneSymbol) uc337jdv.1 uc337jdv.1 
ENSMUST00000351760.1 ENSMUSG00000139194 ENSMUST00000351760.1 ENSMUSG00000139194 (from geneSymbol) uc337jdw.1 uc337jdw.1 
ENSMUST00000351763.1 Gm35333 ENSMUST00000351763.1 Gm35333 (from geneSymbol) uc337jdz.1 uc337jdz.1 
ENSMUST00000351770.1 ENSMUSG00000139195 ENSMUST00000351770.1 ENSMUSG00000139195 (from geneSymbol) uc337jeg.1 uc337jeg.1 
ENSMUST00000351771.1 ENSMUSG00000139196 ENSMUST00000351771.1 ENSMUSG00000139196 (from geneSymbol) uc337jeh.1 uc337jeh.1 
ENSMUST00000351772.1 ENSMUSG00000139197 ENSMUST00000351772.1 ENSMUSG00000139197 (from geneSymbol) uc337jei.1 uc337jei.1 
ENSMUST00000351776.1 ENSMUSG00000139198 ENSMUST00000351776.1 ENSMUSG00000139198 (from geneSymbol) uc337jem.1 uc337jem.1 
ENSMUST00000351790.1 ENSMUSG00000139199 ENSMUST00000351790.1 ENSMUSG00000139199 (from geneSymbol) uc337jfa.1 uc337jfa.1 
ENSMUST00000351791.1 ENSMUSG00000139200 ENSMUST00000351791.1 ENSMUSG00000139200 (from geneSymbol) AK085563 uc337jfb.1 uc337jfb.1 
ENSMUST00000351792.1 ENSMUSG00000139201 ENSMUST00000351792.1 ENSMUSG00000139201 (from geneSymbol) uc337jfc.1 uc337jfc.1 
ENSMUST00000351794.1 ENSMUSG00000139202 ENSMUST00000351794.1 ENSMUSG00000139202 (from geneSymbol) uc337jfe.1 uc337jfe.1 
ENSMUST00000351805.1 ENSMUSG00000139203 ENSMUST00000351805.1 ENSMUSG00000139203 (from geneSymbol) uc337jfp.1 uc337jfp.1 
ENSMUST00000351827.1 Gm56802 ENSMUST00000351827.1 Gm56802 (from geneSymbol) uc337jgl.1 uc337jgl.1 
ENSMUST00000351839.1 ENSMUSG00000139205 ENSMUST00000351839.1 ENSMUSG00000139205 (from geneSymbol) uc337jgw.1 uc337jgw.1 
ENSMUST00000351843.1 ENSMUSG00000139206 ENSMUST00000351843.1 ENSMUSG00000139206 (from geneSymbol) uc337jha.1 uc337jha.1 
ENSMUST00000351849.1 ENSMUSG00000139207 ENSMUST00000351849.1 ENSMUSG00000139207 (from geneSymbol) uc337jhg.1 uc337jhg.1 
ENSMUST00000351876.1 ENSMUSG00000139208 ENSMUST00000351876.1 ENSMUSG00000139208 (from geneSymbol) uc337jih.1 uc337jih.1 
ENSMUST00000351877.1 ENSMUSG00000139209 ENSMUST00000351877.1 ENSMUSG00000139209 (from geneSymbol) uc337jii.1 uc337jii.1 
ENSMUST00000351878.1 ENSMUSG00000139210 ENSMUST00000351878.1 ENSMUSG00000139210 (from geneSymbol) uc337jij.1 uc337jij.1 
ENSMUST00000351879.1 ENSMUSG00000139211 ENSMUST00000351879.1 ENSMUSG00000139211 (from geneSymbol) uc337jik.1 uc337jik.1 
ENSMUST00000351898.1 ENSMUSG00000139212 ENSMUST00000351898.1 ENSMUSG00000139212 (from geneSymbol) uc337jjc.1 uc337jjc.1 
ENSMUST00000351912.1 ENSMUSG00000139213 ENSMUST00000351912.1 ENSMUSG00000139213 (from geneSymbol) uc337jjq.1 uc337jjq.1 
ENSMUST00000351914.1 ENSMUSG00000139214 ENSMUST00000351914.1 ENSMUSG00000139214 (from geneSymbol) uc337jjr.1 uc337jjr.1 
ENSMUST00000351915.1 ENSMUSG00000139215 ENSMUST00000351915.1 ENSMUSG00000139215 (from geneSymbol) uc337jjs.1 uc337jjs.1 
ENSMUST00000351916.1 ENSMUSG00000139216 ENSMUST00000351916.1 ENSMUSG00000139216 (from geneSymbol) uc337jjt.1 uc337jjt.1 
ENSMUST00000351917.1 ENSMUSG00000139217 ENSMUST00000351917.1 ENSMUSG00000139217 (from geneSymbol) uc337jju.1 uc337jju.1 
ENSMUST00000351919.1 ENSMUSG00000139218 ENSMUST00000351919.1 ENSMUSG00000139218 (from geneSymbol) uc337jjw.1 uc337jjw.1 
ENSMUST00000351923.1 ENSMUSG00000139219 ENSMUST00000351923.1 ENSMUSG00000139219 (from geneSymbol) uc337jka.1 uc337jka.1 
ENSMUST00000351926.1 ENSMUSG00000139220 ENSMUST00000351926.1 ENSMUSG00000139220 (from geneSymbol) uc337jkd.1 uc337jkd.1 
ENSMUST00000351929.1 ENSMUSG00000139221 ENSMUST00000351929.1 ENSMUSG00000139221 (from geneSymbol) uc337jkg.1 uc337jkg.1 
ENSMUST00000351930.1 Gm49418 ENSMUST00000351930.1 Gm49418 (from geneSymbol) uc337jkh.1 uc337jkh.1 
ENSMUST00000351935.1 ENSMUSG00000139222 ENSMUST00000351935.1 ENSMUSG00000139222 (from geneSymbol) uc337jkm.1 uc337jkm.1 
ENSMUST00000351970.1 ENSMUSG00000139223 ENSMUST00000351970.1 ENSMUSG00000139223 (from geneSymbol) uc337jlv.1 uc337jlv.1 
ENSMUST00000351974.1 ENSMUSG00000139224 ENSMUST00000351974.1 ENSMUSG00000139224 (from geneSymbol) uc337jlz.1 uc337jlz.1 
ENSMUST00000351976.1 ENSMUSG00000139225 ENSMUST00000351976.1 ENSMUSG00000139225 (from geneSymbol) uc337jmb.1 uc337jmb.1 
ENSMUST00000351979.1 ENSMUSG00000139226 ENSMUST00000351979.1 ENSMUSG00000139226 (from geneSymbol) uc337jme.1 uc337jme.1 
ENSMUST00000351981.1 ENSMUSG00000139227 ENSMUST00000351981.1 ENSMUSG00000139227 (from geneSymbol) uc337jmg.1 uc337jmg.1 
ENSMUST00000351984.1 ENSMUSG00000139228 ENSMUST00000351984.1 ENSMUSG00000139228 (from geneSymbol) uc337jmj.1 uc337jmj.1 
ENSMUST00000351997.1 ENSMUSG00000139229 ENSMUST00000351997.1 ENSMUSG00000139229 (from geneSymbol) uc337jmw.1 uc337jmw.1 
ENSMUST00000351998.1 ENSMUSG00000139230 ENSMUST00000351998.1 ENSMUSG00000139230 (from geneSymbol) uc337jmx.1 uc337jmx.1 
ENSMUST00000352002.1 ENSMUSG00000139231 ENSMUST00000352002.1 ENSMUSG00000139231 (from geneSymbol) uc337jnb.1 uc337jnb.1 
ENSMUST00000352004.1 Gm30375 ENSMUST00000352004.1 predicted gene, 30375 (from RefSeq NR_168598.1) NR_168598 uc337jnd.1 uc337jnd.1 
ENSMUST00000352006.1 ENSMUSG00000139233 ENSMUST00000352006.1 ENSMUSG00000139233 (from geneSymbol) uc337jnf.1 uc337jnf.1 
ENSMUST00000352008.1 Gm56507 ENSMUST00000352008.1 Gm56507 (from geneSymbol) uc337jnh.1 uc337jnh.1 
ENSMUST00000352009.1 ENSMUSG00000139234 ENSMUST00000352009.1 ENSMUSG00000139234 (from geneSymbol) uc337jni.1 uc337jni.1 
ENSMUST00000352010.1 Gm31138 ENSMUST00000352010.1 Gm31138 (from geneSymbol) AK133027 uc337jnj.1 uc337jnj.1 
ENSMUST00000352047.1 ENSMUSG00000139235 ENSMUST00000352047.1 ENSMUSG00000139235 (from geneSymbol) uc337jou.1 uc337jou.1 
ENSMUST00000352058.1 ENSMUSG00000121312 ENSMUST00000352058.1 ENSMUSG00000121312 (from geneSymbol) AK016931 uc337jpf.1 uc337jpf.1 
ENSMUST00000352099.1 ENSMUSG00000139236 ENSMUST00000352099.1 ENSMUSG00000139236 (from geneSymbol) uc337jqu.1 uc337jqu.1 
ENSMUST00000352100.1 ENSMUSG00000139237 ENSMUST00000352100.1 ENSMUSG00000139237 (from geneSymbol) uc337jqv.1 uc337jqv.1 
ENSMUST00000352101.1 ENSMUSG00000139238 ENSMUST00000352101.1 ENSMUSG00000139238 (from geneSymbol) uc337jqw.1 uc337jqw.1 
ENSMUST00000352102.1 ENSMUSG00000139239 ENSMUST00000352102.1 ENSMUSG00000139239 (from geneSymbol) uc337jqx.1 uc337jqx.1 
ENSMUST00000352104.1 ENSMUSG00000139241 ENSMUST00000352104.1 ENSMUSG00000139241 (from geneSymbol) uc337jqy.1 uc337jqy.1 
ENSMUST00000352105.1 ENSMUSG00000139242 ENSMUST00000352105.1 ENSMUSG00000139242 (from geneSymbol) uc337jqz.1 uc337jqz.1 
ENSMUST00000352106.1 ENSMUSG00000139243 ENSMUST00000352106.1 ENSMUSG00000139243 (from geneSymbol) uc337jra.1 uc337jra.1 
ENSMUST00000352110.1 ENSMUSG00000139244 ENSMUST00000352110.1 ENSMUSG00000139244 (from geneSymbol) uc337jre.1 uc337jre.1 
ENSMUST00000352111.1 A530020G20Rik ENSMUST00000352111.1 A530020G20Rik (from geneSymbol) uc337jrf.1 uc337jrf.1 
ENSMUST00000352116.1 ENSMUSG00000139245 ENSMUST00000352116.1 ENSMUSG00000139245 (from geneSymbol) uc337jrk.1 uc337jrk.1 
ENSMUST00000352118.1 ENSMUSG00000139246 ENSMUST00000352118.1 ENSMUSG00000139246 (from geneSymbol) uc337jrm.1 uc337jrm.1 
ENSMUST00000352126.1 ENSMUSG00000139247 ENSMUST00000352126.1 ENSMUSG00000139247 (from geneSymbol) uc337jru.1 uc337jru.1 
ENSMUST00000352130.1 ENSMUSG00000139248 ENSMUST00000352130.1 ENSMUSG00000139248 (from geneSymbol) uc337jry.1 uc337jry.1 
ENSMUST00000352131.1 ENSMUSG00000139249 ENSMUST00000352131.1 ENSMUSG00000139249 (from geneSymbol) uc337jrz.1 uc337jrz.1 
ENSMUST00000352134.1 ENSMUSG00000139250 ENSMUST00000352134.1 ENSMUSG00000139250 (from geneSymbol) uc337jsc.1 uc337jsc.1 
ENSMUST00000352136.1 ENSMUSG00000139251 ENSMUST00000352136.1 ENSMUSG00000139251 (from geneSymbol) uc337jse.1 uc337jse.1 
ENSMUST00000352137.1 ENSMUSG00000139252 ENSMUST00000352137.1 ENSMUSG00000139252 (from geneSymbol) uc337jsf.1 uc337jsf.1 
ENSMUST00000352138.1 ENSMUSG00000139253 ENSMUST00000352138.1 ENSMUSG00000139253 (from geneSymbol) BC099537 uc337jsg.1 uc337jsg.1 
ENSMUST00000352150.1 Gm20139 ENSMUST00000352150.1 Gm20139 (from geneSymbol) AK136014 uc337jsp.1 uc337jsp.1 
ENSMUST00000352159.1 Gm56510 ENSMUST00000352159.1 Gm56510 (from geneSymbol) uc337jsy.1 uc337jsy.1 
ENSMUST00000352197.1 ENSMUSG00000139254 ENSMUST00000352197.1 ENSMUSG00000139254 (from geneSymbol) uc337juk.1 uc337juk.1 
ENSMUST00000352199.1 Gm14114 ENSMUST00000352199.1 Gm14114 (from geneSymbol) uc337jum.1 uc337jum.1 
ENSMUST00000352216.1 ENSMUSG00000139255 ENSMUST00000352216.1 ENSMUSG00000139255 (from geneSymbol) uc337jvd.1 uc337jvd.1 
ENSMUST00000352218.1 ENSMUSG00000139256 ENSMUST00000352218.1 ENSMUSG00000139256 (from geneSymbol) uc337jvf.1 uc337jvf.1 
ENSMUST00000352219.1 ENSMUSG00000139257 ENSMUST00000352219.1 ENSMUSG00000139257 (from geneSymbol) uc337jvg.1 uc337jvg.1 
ENSMUST00000352337.1 ENSMUSG00000139258 ENSMUST00000352337.1 ENSMUSG00000139258 (from geneSymbol) uc337jzr.1 uc337jzr.1 
ENSMUST00000352338.1 ENSMUSG00000139259 ENSMUST00000352338.1 ENSMUSG00000139259 (from geneSymbol) uc337jzs.1 uc337jzs.1 
ENSMUST00000352339.1 ENSMUSG00000139260 ENSMUST00000352339.1 ENSMUSG00000139260 (from geneSymbol) uc337jzt.1 uc337jzt.1 
ENSMUST00000352341.1 ENSMUSG00000139261 ENSMUST00000352341.1 ENSMUSG00000139261 (from geneSymbol) uc337jzv.1 uc337jzv.1 
ENSMUST00000352342.1 ENSMUSG00000139262 ENSMUST00000352342.1 ENSMUSG00000139262 (from geneSymbol) uc337jzw.1 uc337jzw.1 
ENSMUST00000352349.1 ENSMUSG00000139263 ENSMUST00000352349.1 ENSMUSG00000139263 (from geneSymbol) uc337kad.1 uc337kad.1 
ENSMUST00000352352.1 ENSMUSG00000139264 ENSMUST00000352352.1 ENSMUSG00000139264 (from geneSymbol) AK140035 uc337kag.1 uc337kag.1 
ENSMUST00000352358.1 ENSMUSG00000139265 ENSMUST00000352358.1 ENSMUSG00000139265 (from geneSymbol) uc337kam.1 uc337kam.1 
ENSMUST00000352359.1 ENSMUSG00000139266 ENSMUST00000352359.1 ENSMUSG00000139266 (from geneSymbol) uc337kan.1 uc337kan.1 
ENSMUST00000352360.1 ENSMUSG00000139267 ENSMUST00000352360.1 ENSMUSG00000139267 (from geneSymbol) uc337kao.1 uc337kao.1 
ENSMUST00000352368.1 ENSMUSG00000139268 ENSMUST00000352368.1 ENSMUSG00000139268 (from geneSymbol) uc337kaw.1 uc337kaw.1 
ENSMUST00000352369.1 ENSMUSG00000139269 ENSMUST00000352369.1 ENSMUSG00000139269 (from geneSymbol) uc337kax.1 uc337kax.1 
ENSMUST00000352370.1 ENSMUSG00000139270 ENSMUST00000352370.1 ENSMUSG00000139270 (from geneSymbol) uc337kay.1 uc337kay.1 
ENSMUST00000352372.1 ENSMUSG00000139271 ENSMUST00000352372.1 ENSMUSG00000139271 (from geneSymbol) uc337kba.1 uc337kba.1 
ENSMUST00000352373.1 Gm16726 ENSMUST00000352373.1 Gm16726 (from geneSymbol) AK006982 uc337kbb.1 uc337kbb.1 
ENSMUST00000352383.1 ENSMUSG00000139272 ENSMUST00000352383.1 ENSMUSG00000139272 (from geneSymbol) uc337kbl.1 uc337kbl.1 
ENSMUST00000352384.1 ENSMUSG00000139273 ENSMUST00000352384.1 ENSMUSG00000139273 (from geneSymbol) AK084893 uc337kbm.1 uc337kbm.1 
ENSMUST00000352390.1 ENSMUSG00000139274 ENSMUST00000352390.1 ENSMUSG00000139274 (from geneSymbol) uc337kbs.1 uc337kbs.1 
ENSMUST00000352391.1 ENSMUSG00000139275 ENSMUST00000352391.1 ENSMUSG00000139275 (from geneSymbol) uc337kbt.1 uc337kbt.1 
ENSMUST00000352392.1 ENSMUSG00000139276 ENSMUST00000352392.1 ENSMUSG00000139276 (from geneSymbol) uc337kbu.1 uc337kbu.1 
ENSMUST00000352395.1 Gm57142 ENSMUST00000352395.1 Gm57142 (from geneSymbol) uc337kbx.1 uc337kbx.1 
ENSMUST00000352400.1 ENSMUSG00000139277 ENSMUST00000352400.1 ENSMUSG00000139277 (from geneSymbol) uc337kcc.1 uc337kcc.1 
ENSMUST00000352401.1 ENSMUSG00000139278 ENSMUST00000352401.1 ENSMUSG00000139278 (from geneSymbol) uc337kcd.1 uc337kcd.1 
ENSMUST00000352404.1 ENSMUSG00000139279 ENSMUST00000352404.1 ENSMUSG00000139279 (from geneSymbol) uc337kcg.1 uc337kcg.1 
ENSMUST00000352410.1 Gm29771 ENSMUST00000352410.1 Gm29771 (from geneSymbol) uc337kcm.1 uc337kcm.1 
ENSMUST00000352416.1 ENSMUSG00000139280 ENSMUST00000352416.1 ENSMUSG00000139280 (from geneSymbol) uc337kcs.1 uc337kcs.1 
ENSMUST00000352419.1 ENSMUSG00000139281 ENSMUST00000352419.1 ENSMUSG00000139281 (from geneSymbol) uc337kcv.1 uc337kcv.1 
ENSMUST00000352420.1 ENSMUSG00000139282 ENSMUST00000352420.1 ENSMUSG00000139282 (from geneSymbol) uc337kcw.1 uc337kcw.1 
ENSMUST00000352424.1 Gm17399 ENSMUST00000352424.1 Gm17399 (from geneSymbol) AK039053 uc337kda.1 uc337kda.1 
ENSMUST00000352451.1 ENSMUSG00000139283 ENSMUST00000352451.1 ENSMUSG00000139283 (from geneSymbol) uc337keb.1 uc337keb.1 
ENSMUST00000352452.1 ENSMUSG00000139284 ENSMUST00000352452.1 ENSMUSG00000139284 (from geneSymbol) uc337kec.1 uc337kec.1 
ENSMUST00000352453.1 ENSMUSG00000139285 ENSMUST00000352453.1 ENSMUSG00000139285 (from geneSymbol) uc337ked.1 uc337ked.1 
ENSMUST00000352454.1 ENSMUSG00000139286 ENSMUST00000352454.1 ENSMUSG00000139286 (from geneSymbol) uc337kee.1 uc337kee.1 
ENSMUST00000352455.1 ENSMUSG00000139287 ENSMUST00000352455.1 ENSMUSG00000139287 (from geneSymbol) uc337kef.1 uc337kef.1 
ENSMUST00000352463.1 ENSMUSG00000139288 ENSMUST00000352463.1 ENSMUSG00000139288 (from geneSymbol) uc337ken.1 uc337ken.1 
ENSMUST00000352465.1 ENSMUSG00000139289 ENSMUST00000352465.1 ENSMUSG00000139289 (from geneSymbol) uc337kep.1 uc337kep.1 
ENSMUST00000352466.1 ENSMUSG00000139290 ENSMUST00000352466.1 ENSMUSG00000139290 (from geneSymbol) uc337keq.1 uc337keq.1 
ENSMUST00000352468.1 Gm14285 ENSMUST00000352468.1 Gm14285 (from geneSymbol) uc337kes.1 uc337kes.1 
ENSMUST00000352485.1 ENSMUSG00000139291 ENSMUST00000352485.1 ENSMUSG00000139291 (from geneSymbol) uc337kfj.1 uc337kfj.1 
ENSMUST00000352492.1 ENSMUSG00000139292 ENSMUST00000352492.1 ENSMUSG00000139292 (from geneSymbol) uc337kfq.1 uc337kfq.1 
ENSMUST00000352507.1 ENSMUSG00000139293 ENSMUST00000352507.1 ENSMUSG00000139293 (from geneSymbol) uc337kgf.1 uc337kgf.1 
ENSMUST00000352542.1 ENSMUSG00000139294 ENSMUST00000352542.1 ENSMUSG00000139294 (from geneSymbol) uc337kho.1 uc337kho.1 
ENSMUST00000352543.1 ENSMUSG00000139295 ENSMUST00000352543.1 ENSMUSG00000139295 (from geneSymbol) uc337khp.1 uc337khp.1 
ENSMUST00000352548.1 ENSMUSG00000139296 ENSMUST00000352548.1 ENSMUSG00000139296 (from geneSymbol) uc337khu.1 uc337khu.1 
ENSMUST00000352549.1 ENSMUSG00000139297 ENSMUST00000352549.1 ENSMUSG00000139297 (from geneSymbol) uc337khv.1 uc337khv.1 
ENSMUST00000352550.1 ENSMUSG00000139298 ENSMUST00000352550.1 ENSMUSG00000139298 (from geneSymbol) uc337khw.1 uc337khw.1 
ENSMUST00000352570.1 Gm48202 ENSMUST00000352570.1 Gm48202 (from geneSymbol) uc337kiq.1 uc337kiq.1 
ENSMUST00000352589.1 ENSMUSG00000139299 ENSMUST00000352589.1 ENSMUSG00000139299 (from geneSymbol) uc337kjj.1 uc337kjj.1 
ENSMUST00000352594.1 Gm47708 ENSMUST00000352594.1 Gm47708 (from geneSymbol) AK133093 uc337kjo.1 uc337kjo.1 
ENSMUST00000352605.1 ENSMUSG00000139300 ENSMUST00000352605.1 ENSMUSG00000139300 (from geneSymbol) uc337kjz.1 uc337kjz.1 
ENSMUST00000352607.1 ENSMUSG00000139301 ENSMUST00000352607.1 ENSMUSG00000139301 (from geneSymbol) uc337kkb.1 uc337kkb.1 
ENSMUST00000352608.1 ENSMUSG00000139302 ENSMUST00000352608.1 ENSMUSG00000139302 (from geneSymbol) uc337kkc.1 uc337kkc.1 
ENSMUST00000352612.1 ENSMUSG00000139304 ENSMUST00000352612.1 ENSMUSG00000139304 (from geneSymbol) uc337kkf.1 uc337kkf.1 
ENSMUST00000352615.1 ENSMUSG00000139305 ENSMUST00000352615.1 ENSMUSG00000139305 (from geneSymbol) uc337kki.1 uc337kki.1 
ENSMUST00000352617.1 ENSMUSG00000139306 ENSMUST00000352617.1 ENSMUSG00000139306 (from geneSymbol) uc337kkk.1 uc337kkk.1 
ENSMUST00000352620.1 ENSMUSG00000139307 ENSMUST00000352620.1 ENSMUSG00000139307 (from geneSymbol) uc337kkn.1 uc337kkn.1 
ENSMUST00000352622.1 ENSMUSG00000139308 ENSMUST00000352622.1 ENSMUSG00000139308 (from geneSymbol) uc337kkp.1 uc337kkp.1 
ENSMUST00000352623.1 ENSMUSG00000139309 ENSMUST00000352623.1 ENSMUSG00000139309 (from geneSymbol) uc337kkq.1 uc337kkq.1 
ENSMUST00000352624.1 ENSMUSG00000139310 ENSMUST00000352624.1 ENSMUSG00000139310 (from geneSymbol) uc337kkr.1 uc337kkr.1 
ENSMUST00000352625.1 ENSMUSG00000139311 ENSMUST00000352625.1 ENSMUSG00000139311 (from geneSymbol) uc337kks.1 uc337kks.1 
ENSMUST00000352627.1 Gm43449 ENSMUST00000352627.1 Gm43449 (from geneSymbol) uc337kku.1 uc337kku.1 
ENSMUST00000352628.1 ENSMUSG00000139312 ENSMUST00000352628.1 ENSMUSG00000139312 (from geneSymbol) uc337kkv.1 uc337kkv.1 
ENSMUST00000352630.1 ENSMUSG00000139313 ENSMUST00000352630.1 ENSMUSG00000139313 (from geneSymbol) uc337kkx.1 uc337kkx.1 
ENSMUST00000352631.1 ENSMUSG00000139314 ENSMUST00000352631.1 ENSMUSG00000139314 (from geneSymbol) uc337kky.1 uc337kky.1 
ENSMUST00000352632.1 ENSMUSG00000139315 ENSMUST00000352632.1 ENSMUSG00000139315 (from geneSymbol) uc337kkz.1 uc337kkz.1 
ENSMUST00000352633.1 ENSMUSG00000139316 ENSMUST00000352633.1 ENSMUSG00000139316 (from geneSymbol) uc337kla.1 uc337kla.1 
ENSMUST00000352635.1 ENSMUSG00000139317 ENSMUST00000352635.1 ENSMUSG00000139317 (from geneSymbol) uc337klc.1 uc337klc.1 
ENSMUST00000352637.1 ENSMUSG00000139318 ENSMUST00000352637.1 ENSMUSG00000139318 (from geneSymbol) uc337kle.1 uc337kle.1 
ENSMUST00000352638.1 ENSMUSG00000139319 ENSMUST00000352638.1 ENSMUSG00000139319 (from geneSymbol) uc337klf.1 uc337klf.1 
ENSMUST00000352652.1 ENSMUSG00000139320 ENSMUST00000352652.1 ENSMUSG00000139320 (from geneSymbol) uc337klt.1 uc337klt.1 
ENSMUST00000352653.1 D930003E18Rik ENSMUST00000352653.1 RIKEN cDNA D930003E18 gene (from RefSeq NR_165656.1) NR_165656 uc337klu.1 uc337klu.1 
ENSMUST00000352654.1 ENSMUSG00000139322 ENSMUST00000352654.1 ENSMUSG00000139322 (from geneSymbol) uc337klv.1 uc337klv.1 
ENSMUST00000352655.1 ENSMUSG00000139323 ENSMUST00000352655.1 ENSMUSG00000139323 (from geneSymbol) uc337klw.1 uc337klw.1 
ENSMUST00000352656.1 ENSMUSG00000139324 ENSMUST00000352656.1 ENSMUSG00000139324 (from geneSymbol) uc337klx.1 uc337klx.1 
ENSMUST00000352657.1 ENSMUSG00000139325 ENSMUST00000352657.1 ENSMUSG00000139325 (from geneSymbol) uc337kly.1 uc337kly.1 
ENSMUST00000352661.1 ENSMUSG00000139326 ENSMUST00000352661.1 ENSMUSG00000139326 (from geneSymbol) uc337kmc.1 uc337kmc.1 
ENSMUST00000352662.1 ENSMUSG00000139327 ENSMUST00000352662.1 ENSMUSG00000139327 (from geneSymbol) uc337kmd.1 uc337kmd.1 
ENSMUST00000352663.1 ENSMUSG00000139328 ENSMUST00000352663.1 ENSMUSG00000139328 (from geneSymbol) uc337kme.1 uc337kme.1 
ENSMUST00000352667.1 ENSMUSG00000139329 ENSMUST00000352667.1 ENSMUSG00000139329 (from geneSymbol) uc337kmi.1 uc337kmi.1 
ENSMUST00000352671.1 ENSMUSG00000139330 ENSMUST00000352671.1 ENSMUSG00000139330 (from geneSymbol) uc337kmm.1 uc337kmm.1 
ENSMUST00000352673.1 ENSMUSG00000139331 ENSMUST00000352673.1 ENSMUSG00000139331 (from geneSymbol) uc337kmo.1 uc337kmo.1 
ENSMUST00000352674.1 ENSMUSG00000139332 ENSMUST00000352674.1 ENSMUSG00000139332 (from geneSymbol) uc337kmp.1 uc337kmp.1 
ENSMUST00000352676.1 ENSMUSG00000139333 ENSMUST00000352676.1 ENSMUSG00000139333 (from geneSymbol) uc337kmr.1 uc337kmr.1 
ENSMUST00000352677.1 ENSMUSG00000139334 ENSMUST00000352677.1 ENSMUSG00000139334 (from geneSymbol) uc337kms.1 uc337kms.1 
ENSMUST00000352684.1 ENSMUSG00000139335 ENSMUST00000352684.1 ENSMUSG00000139335 (from geneSymbol) uc337kmz.1 uc337kmz.1 
ENSMUST00000352687.1 ENSMUSG00000139336 ENSMUST00000352687.1 ENSMUSG00000139336 (from geneSymbol) uc337knc.1 uc337knc.1 
ENSMUST00000352688.1 ENSMUSG00000139337 ENSMUST00000352688.1 ENSMUSG00000139337 (from geneSymbol) uc337knd.1 uc337knd.1 
ENSMUST00000352689.1 ENSMUSG00000139338 ENSMUST00000352689.1 ENSMUSG00000139338 (from geneSymbol) uc337kne.1 uc337kne.1 
ENSMUST00000352690.1 ENSMUSG00000139339 ENSMUST00000352690.1 ENSMUSG00000139339 (from geneSymbol) uc337knf.1 uc337knf.1 
ENSMUST00000352692.1 Gm34978 ENSMUST00000352692.1 Gm34978 (from geneSymbol) uc337knh.1 uc337knh.1 
ENSMUST00000352718.1 ENSMUSG00000139340 ENSMUST00000352718.1 ENSMUSG00000139340 (from geneSymbol) uc337koh.1 uc337koh.1 
ENSMUST00000352738.1 D230030E09Rik ENSMUST00000352738.1 D230030E09Rik (from geneSymbol) AK084355 uc337kpb.1 uc337kpb.1 
ENSMUST00000352749.1 4930570G19Rik ENSMUST00000352749.1 4930570G19Rik (from geneSymbol) BC048612 uc337kpm.1 uc337kpm.1 
ENSMUST00000352797.1 Gm42529 ENSMUST00000352797.1 Gm42529 (from geneSymbol) uc337kri.1 uc337kri.1 
ENSMUST00000352802.1 ENSMUSG00000139341 ENSMUST00000352802.1 ENSMUSG00000139341 (from geneSymbol) uc337krn.1 uc337krn.1 
ENSMUST00000352806.1 ENSMUSG00000139342 ENSMUST00000352806.1 ENSMUSG00000139342 (from geneSymbol) uc337krr.1 uc337krr.1 
ENSMUST00000352807.1 ENSMUSG00000139343 ENSMUST00000352807.1 ENSMUSG00000139343 (from geneSymbol) uc337krs.1 uc337krs.1 
ENSMUST00000352810.1 ENSMUSG00000139344 ENSMUST00000352810.1 ENSMUSG00000139344 (from geneSymbol) uc337krv.1 uc337krv.1 
ENSMUST00000352811.1 4921513I03Rik ENSMUST00000352811.1 4921513I03Rik (from geneSymbol) AK076916 uc337krw.1 uc337krw.1 
ENSMUST00000352818.1 ENSMUSG00000139345 ENSMUST00000352818.1 ENSMUSG00000139345 (from geneSymbol) uc337ksd.1 uc337ksd.1 
ENSMUST00000352821.1 ENSMUSG00000139346 ENSMUST00000352821.1 ENSMUSG00000139346 (from geneSymbol) uc337ksg.1 uc337ksg.1 
ENSMUST00000352823.1 1110019B22Rik ENSMUST00000352823.1 1110019B22Rik (from geneSymbol) AK002250 uc337ksi.1 uc337ksi.1 
ENSMUST00000352832.1 ENSMUSG00000139347 ENSMUST00000352832.1 ENSMUSG00000139347 (from geneSymbol) uc337ksr.1 uc337ksr.1 
ENSMUST00000352834.1 ENSMUSG00000139348 ENSMUST00000352834.1 ENSMUSG00000139348 (from geneSymbol) uc337kst.1 uc337kst.1 
ENSMUST00000352835.1 ENSMUSG00000139349 ENSMUST00000352835.1 ENSMUSG00000139349 (from geneSymbol) uc337ksu.1 uc337ksu.1 
ENSMUST00000352838.1 ENSMUSG00000139350 ENSMUST00000352838.1 ENSMUSG00000139350 (from geneSymbol) uc337ksx.1 uc337ksx.1 
ENSMUST00000352839.1 ENSMUSG00000139351 ENSMUST00000352839.1 ENSMUSG00000139351 (from geneSymbol) uc337ksy.1 uc337ksy.1 
ENSMUST00000352840.1 ENSMUSG00000139352 ENSMUST00000352840.1 ENSMUSG00000139352 (from geneSymbol) uc337ksz.1 uc337ksz.1 
ENSMUST00000352842.1 ENSMUSG00000139353 ENSMUST00000352842.1 ENSMUSG00000139353 (from geneSymbol) uc337ktb.1 uc337ktb.1 
ENSMUST00000352843.1 Gm26689 ENSMUST00000352843.1 Gm26689 (from geneSymbol) AK015488 uc337ktc.1 uc337ktc.1 
ENSMUST00000352848.1 ENSMUSG00000139355 ENSMUST00000352848.1 ENSMUSG00000139355 (from geneSymbol) uc337kth.1 uc337kth.1 
ENSMUST00000352852.1 ENSMUSG00000139357 ENSMUST00000352852.1 ENSMUSG00000139357 (from geneSymbol) uc337ktk.1 uc337ktk.1 
ENSMUST00000352866.1 ENSMUSG00000139358 ENSMUST00000352866.1 ENSMUSG00000139358 (from geneSymbol) uc337kty.1 uc337kty.1 
ENSMUST00000352867.1 ENSMUSG00000139359 ENSMUST00000352867.1 ENSMUSG00000139359 (from geneSymbol) uc337ktz.1 uc337ktz.1 
ENSMUST00000352868.1 ENSMUSG00000139360 ENSMUST00000352868.1 ENSMUSG00000139360 (from geneSymbol) uc337kua.1 uc337kua.1 
ENSMUST00000352869.1 ENSMUSG00000139361 ENSMUST00000352869.1 ENSMUSG00000139361 (from geneSymbol) uc337kub.1 uc337kub.1 
ENSMUST00000352870.1 ENSMUSG00000139362 ENSMUST00000352870.1 ENSMUSG00000139362 (from geneSymbol) uc337kuc.1 uc337kuc.1 
ENSMUST00000352872.1 ENSMUSG00000139363 ENSMUST00000352872.1 ENSMUSG00000139363 (from geneSymbol) uc337kue.1 uc337kue.1 
ENSMUST00000352875.1 ENSMUSG00000139364 ENSMUST00000352875.1 ENSMUSG00000139364 (from geneSymbol) uc337kuf.1 uc337kuf.1 
ENSMUST00000352879.1 ENSMUSG00000139365 ENSMUST00000352879.1 ENSMUSG00000139365 (from geneSymbol) uc337kui.1 uc337kui.1 
ENSMUST00000352881.1 Gm50477 ENSMUST00000352881.1 Gm50477 (from geneSymbol) uc337kuk.1 uc337kuk.1 
ENSMUST00000352882.1 ENSMUSG00000139366 ENSMUST00000352882.1 ENSMUSG00000139366 (from geneSymbol) uc337kul.1 uc337kul.1 
ENSMUST00000352883.1 ENSMUSG00000139367 ENSMUST00000352883.1 ENSMUSG00000139367 (from geneSymbol) uc337kum.1 uc337kum.1 
ENSMUST00000352884.1 ENSMUSG00000139368 ENSMUST00000352884.1 ENSMUSG00000139368 (from geneSymbol) uc337kun.1 uc337kun.1 
ENSMUST00000352887.1 ENSMUSG00000139369 ENSMUST00000352887.1 ENSMUSG00000139369 (from geneSymbol) uc337kuq.1 uc337kuq.1 
ENSMUST00000352889.1 ENSMUSG00000139370 ENSMUST00000352889.1 ENSMUSG00000139370 (from geneSymbol) uc337kus.1 uc337kus.1 
ENSMUST00000352890.1 ENSMUSG00000139371 ENSMUST00000352890.1 ENSMUSG00000139371 (from geneSymbol) uc337kut.1 uc337kut.1 
ENSMUST00000352891.1 ENSMUSG00000139372 ENSMUST00000352891.1 ENSMUSG00000139372 (from geneSymbol) uc337kuu.1 uc337kuu.1 
ENSMUST00000352894.1 ENSMUSG00000139373 ENSMUST00000352894.1 ENSMUSG00000139373 (from geneSymbol) LF202114 uc337kux.1 uc337kux.1 
ENSMUST00000352896.1 ENSMUSG00000139374 ENSMUST00000352896.1 ENSMUSG00000139374 (from geneSymbol) uc337kuz.1 uc337kuz.1 
ENSMUST00000352906.1 ENSMUSG00000139375 ENSMUST00000352906.1 ENSMUSG00000139375 (from geneSymbol) uc337kvj.1 uc337kvj.1 
ENSMUST00000352909.1 ENSMUSG00000139376 ENSMUST00000352909.1 ENSMUSG00000139376 (from geneSymbol) uc337kvm.1 uc337kvm.1 
ENSMUST00000352910.1 ENSMUSG00000139377 ENSMUST00000352910.1 ENSMUSG00000139377 (from geneSymbol) uc337kvn.1 uc337kvn.1 
ENSMUST00000352911.1 ENSMUSG00000139378 ENSMUST00000352911.1 ENSMUSG00000139378 (from geneSymbol) uc337kvo.1 uc337kvo.1 
ENSMUST00000352919.1 ENSMUSG00000139379 ENSMUST00000352919.1 ENSMUSG00000139379 (from geneSymbol) uc337kvw.1 uc337kvw.1 
ENSMUST00000352920.1 ENSMUSG00000139380 ENSMUST00000352920.1 ENSMUSG00000139380 (from geneSymbol) uc337kvx.1 uc337kvx.1 
ENSMUST00000352921.1 ENSMUSG00000139381 ENSMUST00000352921.1 ENSMUSG00000139381 (from geneSymbol) uc337kvy.1 uc337kvy.1 
ENSMUST00000352922.1 ENSMUSG00000139382 ENSMUST00000352922.1 ENSMUSG00000139382 (from geneSymbol) uc337kvz.1 uc337kvz.1 
ENSMUST00000352923.1 ENSMUSG00000139383 ENSMUST00000352923.1 ENSMUSG00000139383 (from geneSymbol) uc337kwa.1 uc337kwa.1 
ENSMUST00000352924.1 ENSMUSG00000139384 ENSMUST00000352924.1 ENSMUSG00000139384 (from geneSymbol) uc337kwb.1 uc337kwb.1 
ENSMUST00000352934.1 ENSMUSG00000139385 ENSMUST00000352934.1 ENSMUSG00000139385 (from geneSymbol) uc337kwl.1 uc337kwl.1 
ENSMUST00000352936.1 ENSMUSG00000139386 ENSMUST00000352936.1 ENSMUSG00000139386 (from geneSymbol) uc337kwn.1 uc337kwn.1 
ENSMUST00000352937.1 ENSMUSG00000139387 ENSMUST00000352937.1 ENSMUSG00000139387 (from geneSymbol) uc337kwo.1 uc337kwo.1 
ENSMUST00000352940.1 Gm56563 ENSMUST00000352940.1 Gm56563 (from geneSymbol) uc337kwr.1 uc337kwr.1 
ENSMUST00000352944.1 ENSMUSG00000139388 ENSMUST00000352944.1 ENSMUSG00000139388 (from geneSymbol) uc337kwv.1 uc337kwv.1 
ENSMUST00000352945.1 ENSMUSG00000139389 ENSMUST00000352945.1 ENSMUSG00000139389 (from geneSymbol) uc337kww.1 uc337kww.1 
ENSMUST00000352946.1 ENSMUSG00000139390 ENSMUST00000352946.1 ENSMUSG00000139390 (from geneSymbol) uc337kwx.1 uc337kwx.1 
ENSMUST00000352947.1 Gm4473 ENSMUST00000352947.1 Gm4473 (from geneSymbol) uc337kwy.1 uc337kwy.1 
ENSMUST00000352953.1 ENSMUSG00000139391 ENSMUST00000352953.1 ENSMUSG00000139391 (from geneSymbol) uc337kxe.1 uc337kxe.1 
ENSMUST00000352964.1 Gm13348 ENSMUST00000352964.1 predicted gene 13348, transcript variant 3 (from RefSeq NR_166089.1) NR_166089 uc337kxp.1 uc337kxp.1 
ENSMUST00000352974.1 ENSMUSG00000139392 ENSMUST00000352974.1 ENSMUSG00000139392 (from geneSymbol) uc337kxz.1 uc337kxz.1 
ENSMUST00000352983.1 ENSMUSG00000139393 ENSMUST00000352983.1 ENSMUSG00000139393 (from geneSymbol) uc337kyi.1 uc337kyi.1 
ENSMUST00000352985.1 ENSMUSG00000139394 ENSMUST00000352985.1 ENSMUSG00000139394 (from geneSymbol) uc337kyk.1 uc337kyk.1 
ENSMUST00000352986.1 2310020H05Rik ENSMUST00000352986.1 2310020H05Rik (from geneSymbol) AK009418 uc337kyl.1 uc337kyl.1 
ENSMUST00000353030.1 ENSMUSG00000139395 ENSMUST00000353030.1 ENSMUSG00000139395 (from geneSymbol) uc337lab.1 uc337lab.1 
ENSMUST00000353068.1 1810012K08Rik ENSMUST00000353068.1 1810012K08Rik (from geneSymbol) AK007459 uc337lbn.1 uc337lbn.1 
ENSMUST00000353069.1 ENSMUSG00000139396 ENSMUST00000353069.1 ENSMUSG00000139396 (from geneSymbol) uc337lbo.1 uc337lbo.1 
ENSMUST00000353070.1 ENSMUSG00000139397 ENSMUST00000353070.1 ENSMUSG00000139397 (from geneSymbol) uc337lbp.1 uc337lbp.1 
ENSMUST00000353071.1 ENSMUSG00000139398 ENSMUST00000353071.1 ENSMUSG00000139398 (from geneSymbol) uc337lbq.1 uc337lbq.1 
ENSMUST00000353073.1 ENSMUSG00000139399 ENSMUST00000353073.1 ENSMUSG00000139399 (from geneSymbol) uc337lbs.1 uc337lbs.1 
ENSMUST00000353096.1 ENSMUSG00000139400 ENSMUST00000353096.1 ENSMUSG00000139400 (from geneSymbol) uc337lcp.1 uc337lcp.1 
ENSMUST00000353099.1 ENSMUSG00000139401 ENSMUST00000353099.1 ENSMUSG00000139401 (from geneSymbol) uc337lcs.1 uc337lcs.1 
ENSMUST00000353101.1 ENSMUSG00000139402 ENSMUST00000353101.1 ENSMUSG00000139402 (from geneSymbol) uc337lcu.1 uc337lcu.1 
ENSMUST00000353104.1 ENSMUSG00000139403 ENSMUST00000353104.1 ENSMUSG00000139403 (from geneSymbol) uc337lcx.1 uc337lcx.1 
ENSMUST00000353110.1 ENSMUSG00000139404 ENSMUST00000353110.1 ENSMUSG00000139404 (from geneSymbol) uc337ldd.1 uc337ldd.1 
ENSMUST00000353112.1 ENSMUSG00000139405 ENSMUST00000353112.1 ENSMUSG00000139405 (from geneSymbol) uc337ldf.1 uc337ldf.1 
ENSMUST00000353114.1 Gm38562 ENSMUST00000353114.1 Gm38562 (from geneSymbol) AK158824 uc337ldh.1 uc337ldh.1 
ENSMUST00000353117.1 ENSMUSG00000139406 ENSMUST00000353117.1 ENSMUSG00000139406 (from geneSymbol) uc337ldk.1 uc337ldk.1 
ENSMUST00000353118.1 ENSMUSG00000139407 ENSMUST00000353118.1 ENSMUSG00000139407 (from geneSymbol) uc337ldl.1 uc337ldl.1 
ENSMUST00000353123.1 ENSMUSG00000139408 ENSMUST00000353123.1 ENSMUSG00000139408 (from geneSymbol) uc337ldq.1 uc337ldq.1 
ENSMUST00000353126.1 ENSMUSG00000139409 ENSMUST00000353126.1 ENSMUSG00000139409 (from geneSymbol) uc337ldt.1 uc337ldt.1 
ENSMUST00000353127.1 Gm33103 ENSMUST00000353127.1 Gm33103 (from geneSymbol) uc337ldu.1 uc337ldu.1 
ENSMUST00000353135.1 ENSMUSG00000139410 ENSMUST00000353135.1 ENSMUSG00000139410 (from geneSymbol) uc337lec.1 uc337lec.1 
ENSMUST00000353138.1 ENSMUSG00000139411 ENSMUST00000353138.1 ENSMUSG00000139411 (from geneSymbol) uc337lef.1 uc337lef.1 
ENSMUST00000353154.1 ENSMUSG00000139412 ENSMUST00000353154.1 ENSMUSG00000139412 (from geneSymbol) uc337lev.1 uc337lev.1 
ENSMUST00000353156.1 ENSMUSG00000139413 ENSMUST00000353156.1 ENSMUSG00000139413 (from geneSymbol) uc337lex.1 uc337lex.1 
ENSMUST00000353157.1 ENSMUSG00000139414 ENSMUST00000353157.1 ENSMUSG00000139414 (from geneSymbol) uc337ley.1 uc337ley.1 
ENSMUST00000353163.1 ENSMUSG00000139416 ENSMUST00000353163.1 ENSMUSG00000139416 (from geneSymbol) uc337lez.1 uc337lez.1 
ENSMUST00000353164.1 ENSMUSG00000139417 ENSMUST00000353164.1 ENSMUSG00000139417 (from geneSymbol) uc337lfa.1 uc337lfa.1 
ENSMUST00000353165.1 ENSMUSG00000139418 ENSMUST00000353165.1 ENSMUSG00000139418 (from geneSymbol) uc337lfb.1 uc337lfb.1 
ENSMUST00000353166.1 ENSMUSG00000139419 ENSMUST00000353166.1 ENSMUSG00000139419 (from geneSymbol) uc337lfc.1 uc337lfc.1 
ENSMUST00000353168.1 ENSMUSG00000139420 ENSMUST00000353168.1 ENSMUSG00000139420 (from geneSymbol) uc337lfe.1 uc337lfe.1 
ENSMUST00000353173.1 ENSMUSG00000139421 ENSMUST00000353173.1 ENSMUSG00000139421 (from geneSymbol) uc337lfj.1 uc337lfj.1 
ENSMUST00000353176.1 ENSMUSG00000139422 ENSMUST00000353176.1 ENSMUSG00000139422 (from geneSymbol) uc337lfm.1 uc337lfm.1 
ENSMUST00000353182.1 ENSMUSG00000139423 ENSMUST00000353182.1 ENSMUSG00000139423 (from geneSymbol) uc337lfs.1 uc337lfs.1 
ENSMUST00000353185.1 Gm33104 ENSMUST00000353185.1 Gm33104 (from geneSymbol) AK029599 uc337lfv.1 uc337lfv.1 
ENSMUST00000353229.1 ENSMUSG00000139424 ENSMUST00000353229.1 ENSMUSG00000139424 (from geneSymbol) uc337lhm.1 uc337lhm.1 
ENSMUST00000353230.1 ENSMUSG00000139425 ENSMUST00000353230.1 ENSMUSG00000139425 (from geneSymbol) uc337lhn.1 uc337lhn.1 
ENSMUST00000353231.1 Gm40830 ENSMUST00000353231.1 predicted gene, 40830, transcript variant 1 (from RefSeq NR_188795.1) NR_188795 uc337lho.1 uc337lho.1 
ENSMUST00000353238.1 ENSMUSG00000139426 ENSMUST00000353238.1 ENSMUSG00000139426 (from geneSymbol) uc337lhv.1 uc337lhv.1 
ENSMUST00000353239.1 ENSMUSG00000139427 ENSMUST00000353239.1 ENSMUSG00000139427 (from geneSymbol) uc337lhw.1 uc337lhw.1 
ENSMUST00000353240.1 ENSMUSG00000139428 ENSMUST00000353240.1 ENSMUSG00000139428 (from geneSymbol) uc337lhx.1 uc337lhx.1 
ENSMUST00000353249.1 Gm12984 ENSMUST00000353249.1 Gm12984 (from geneSymbol) uc337lig.1 uc337lig.1 
ENSMUST00000353260.1 ENSMUSG00000139429 ENSMUST00000353260.1 ENSMUSG00000139429 (from geneSymbol) uc337lir.1 uc337lir.1 
ENSMUST00000353266.1 ENSMUSG00000139430 ENSMUST00000353266.1 ENSMUSG00000139430 (from geneSymbol) uc337lix.1 uc337lix.1 
ENSMUST00000353269.1 ENSMUSG00000139431 ENSMUST00000353269.1 predicted gene, 34220, transcript variant 1 (from RefSeq NR_189041.1) NR_189041 uc337lja.1 uc337lja.1 
ENSMUST00000353272.1 ENSMUSG00000139432 ENSMUST00000353272.1 ENSMUSG00000139432 (from geneSymbol) uc337ljd.1 uc337ljd.1 
ENSMUST00000353276.1 Gm48116 ENSMUST00000353276.1 Gm48116 (from geneSymbol) uc337ljh.1 uc337ljh.1 
ENSMUST00000353278.1 ENSMUSG00000139433 ENSMUST00000353278.1 ENSMUSG00000139433 (from geneSymbol) uc337ljj.1 uc337ljj.1 
ENSMUST00000353279.1 ENSMUSG00000139434 ENSMUST00000353279.1 ENSMUSG00000139434 (from geneSymbol) uc337ljk.1 uc337ljk.1 
ENSMUST00000353280.1 ENSMUSG00000139435 ENSMUST00000353280.1 ENSMUSG00000139435 (from geneSymbol) uc337ljl.1 uc337ljl.1 
ENSMUST00000353281.1 ENSMUSG00000139436 ENSMUST00000353281.1 ENSMUSG00000139436 (from geneSymbol) uc337ljm.1 uc337ljm.1 
ENSMUST00000353283.1 Gm57433 ENSMUST00000353283.1 Gm57433 (from geneSymbol) uc337ljo.1 uc337ljo.1 
ENSMUST00000353285.1 ENSMUSG00000139437 ENSMUST00000353285.1 ENSMUSG00000139437 (from geneSymbol) uc337ljq.1 uc337ljq.1 
ENSMUST00000353288.1 ENSMUSG00000139438 ENSMUST00000353288.1 ENSMUSG00000139438 (from geneSymbol) uc337ljt.1 uc337ljt.1 
ENSMUST00000353297.1 ENSMUSG00000139439 ENSMUST00000353297.1 ENSMUSG00000139439 (from geneSymbol) uc337lkc.1 uc337lkc.1 
ENSMUST00000353298.1 ENSMUSG00000139440 ENSMUST00000353298.1 ENSMUSG00000139440 (from geneSymbol) uc337lkd.1 uc337lkd.1 
ENSMUST00000353300.1 ENSMUSG00000139441 ENSMUST00000353300.1 ENSMUSG00000139441 (from geneSymbol) uc337lkf.1 uc337lkf.1 
ENSMUST00000353302.1 ENSMUSG00000139442 ENSMUST00000353302.1 ENSMUSG00000139442 (from geneSymbol) uc337lkh.1 uc337lkh.1 
ENSMUST00000353305.1 ENSMUSG00000139443 ENSMUST00000353305.1 ENSMUSG00000139443 (from geneSymbol) uc337lkk.1 uc337lkk.1 
ENSMUST00000353306.1 ENSMUSG00000139444 ENSMUST00000353306.1 ENSMUSG00000139444 (from geneSymbol) uc337lkl.1 uc337lkl.1 
ENSMUST00000353307.1 ENSMUSG00000139445 ENSMUST00000353307.1 ENSMUSG00000139445 (from geneSymbol) uc337lkm.1 uc337lkm.1 
ENSMUST00000353309.1 ENSMUSG00000139446 ENSMUST00000353309.1 ENSMUSG00000139446 (from geneSymbol) uc337lko.1 uc337lko.1 
ENSMUST00000353310.1 ENSMUSG00000139447 ENSMUST00000353310.1 ENSMUSG00000139447 (from geneSymbol) uc337lkp.1 uc337lkp.1 
ENSMUST00000353311.1 ENSMUSG00000139448 ENSMUST00000353311.1 ENSMUSG00000139448 (from geneSymbol) uc337lkq.1 uc337lkq.1 
ENSMUST00000353313.1 ENSMUSG00000139449 ENSMUST00000353313.1 ENSMUSG00000139449 (from geneSymbol) AK143754 uc337lks.1 uc337lks.1 
ENSMUST00000353314.1 ENSMUSG00000139450 ENSMUST00000353314.1 ENSMUSG00000139450 (from geneSymbol) uc337lkt.1 uc337lkt.1 
ENSMUST00000353315.1 ENSMUSG00000139451 ENSMUST00000353315.1 ENSMUSG00000139451 (from geneSymbol) uc337lku.1 uc337lku.1 
ENSMUST00000353316.1 ENSMUSG00000139452 ENSMUST00000353316.1 ENSMUSG00000139452 (from geneSymbol) uc337lkv.1 uc337lkv.1 
ENSMUST00000353317.1 ENSMUSG00000139453 ENSMUST00000353317.1 ENSMUSG00000139453 (from geneSymbol) uc337lkw.1 uc337lkw.1 
ENSMUST00000353321.1 ENSMUSG00000139454 ENSMUST00000353321.1 ENSMUSG00000139454 (from geneSymbol) uc337lla.1 uc337lla.1 
ENSMUST00000353325.1 ENSMUSG00000139455 ENSMUST00000353325.1 ENSMUSG00000139455 (from geneSymbol) uc337lle.1 uc337lle.1 
ENSMUST00000353326.1 ENSMUSG00000139456 ENSMUST00000353326.1 ENSMUSG00000139456 (from geneSymbol) uc337llf.1 uc337llf.1 
ENSMUST00000353327.1 ENSMUSG00000139457 ENSMUST00000353327.1 ENSMUSG00000139457 (from geneSymbol) uc337llg.1 uc337llg.1 
ENSMUST00000353328.1 ENSMUSG00000139458 ENSMUST00000353328.1 ENSMUSG00000139458 (from geneSymbol) uc337llh.1 uc337llh.1 
ENSMUST00000353330.1 ENSMUSG00000139459 ENSMUST00000353330.1 ENSMUSG00000139459 (from geneSymbol) DQ710270 uc337llj.1 uc337llj.1 
ENSMUST00000353340.1 ENSMUSG00000139460 ENSMUST00000353340.1 ENSMUSG00000139460 (from geneSymbol) uc337llt.1 uc337llt.1 
ENSMUST00000353342.1 ENSMUSG00000139461 ENSMUST00000353342.1 ENSMUSG00000139461 (from geneSymbol) uc337llv.1 uc337llv.1 
ENSMUST00000353346.1 ENSMUSG00000139462 ENSMUST00000353346.1 ENSMUSG00000139462 (from geneSymbol) uc337llz.1 uc337llz.1 
ENSMUST00000353347.1 ENSMUSG00000139463 ENSMUST00000353347.1 ENSMUSG00000139463 (from geneSymbol) uc337lma.1 uc337lma.1 
ENSMUST00000353350.1 ENSMUSG00000139464 ENSMUST00000353350.1 ENSMUSG00000139464 (from geneSymbol) uc337lmd.1 uc337lmd.1 
ENSMUST00000353352.1 ENSMUSG00000139465 ENSMUST00000353352.1 ENSMUSG00000139465 (from geneSymbol) uc337lmf.1 uc337lmf.1 
ENSMUST00000353357.1 5330413D20Rik ENSMUST00000353357.1 5330413D20Rik (from geneSymbol) uc337lmk.1 uc337lmk.1 
ENSMUST00000353358.1 ENSMUSG00000139466 ENSMUST00000353358.1 ENSMUSG00000139466 (from geneSymbol) uc337lml.1 uc337lml.1 
ENSMUST00000353359.1 ENSMUSG00000139467 ENSMUST00000353359.1 ENSMUSG00000139467 (from geneSymbol) uc337lmm.1 uc337lmm.1 
ENSMUST00000353360.1 ENSMUSG00000139468 ENSMUST00000353360.1 ENSMUSG00000139468 (from geneSymbol) uc337lmn.1 uc337lmn.1 
ENSMUST00000353362.1 ENSMUSG00000139469 ENSMUST00000353362.1 ENSMUSG00000139469 (from geneSymbol) uc337lmp.1 uc337lmp.1 
ENSMUST00000353367.1 Gm15961 ENSMUST00000353367.1 Gm15961 (from geneSymbol) uc337lmu.1 uc337lmu.1 
ENSMUST00000353368.1 ENSMUSG00000139470 ENSMUST00000353368.1 ENSMUSG00000139470 (from geneSymbol) uc337lmv.1 uc337lmv.1 
ENSMUST00000353369.1 ENSMUSG00000139471 ENSMUST00000353369.1 ENSMUSG00000139471 (from geneSymbol) uc337lmw.1 uc337lmw.1 
ENSMUST00000353372.1 ENSMUSG00000139472 ENSMUST00000353372.1 ENSMUSG00000139472 (from geneSymbol) uc337lmz.1 uc337lmz.1 
ENSMUST00000353373.1 ENSMUSG00000139473 ENSMUST00000353373.1 ENSMUSG00000139473 (from geneSymbol) uc337lna.1 uc337lna.1 
ENSMUST00000353376.1 ENSMUSG00000139474 ENSMUST00000353376.1 ENSMUSG00000139474 (from geneSymbol) uc337lnd.1 uc337lnd.1 
ENSMUST00000353382.1 ENSMUSG00000139475 ENSMUST00000353382.1 ENSMUSG00000139475 (from geneSymbol) uc337lnj.1 uc337lnj.1 
ENSMUST00000353383.1 ENSMUSG00000139476 ENSMUST00000353383.1 ENSMUSG00000139476 (from geneSymbol) uc337lnk.1 uc337lnk.1 
ENSMUST00000353385.1 ENSMUSG00000139477 ENSMUST00000353385.1 ENSMUSG00000139477 (from geneSymbol) uc337lnm.1 uc337lnm.1 
ENSMUST00000353386.1 ENSMUSG00000139478 ENSMUST00000353386.1 ENSMUSG00000139478 (from geneSymbol) uc337lnn.1 uc337lnn.1 
ENSMUST00000353388.1 ENSMUSG00000139479 ENSMUST00000353388.1 ENSMUSG00000139479 (from geneSymbol) uc337lnp.1 uc337lnp.1 
ENSMUST00000353390.1 ENSMUSG00000139480 ENSMUST00000353390.1 ENSMUSG00000139480 (from geneSymbol) uc337lnr.1 uc337lnr.1 
ENSMUST00000353391.1 ENSMUSG00000139481 ENSMUST00000353391.1 ENSMUSG00000139481 (from geneSymbol) uc337lns.1 uc337lns.1 
ENSMUST00000353396.1 Gm26740 ENSMUST00000353396.1 Gm26740 (from geneSymbol) AK041973 uc337lnx.1 uc337lnx.1 
ENSMUST00000353511.1 ENSMUSG00000139482 ENSMUST00000353511.1 ENSMUSG00000139482 (from geneSymbol) uc337lsg.1 uc337lsg.1 
ENSMUST00000353512.1 ENSMUSG00000139483 ENSMUST00000353512.1 ENSMUSG00000139483 (from geneSymbol) uc337lsh.1 uc337lsh.1 
ENSMUST00000353513.1 ENSMUSG00000139484 ENSMUST00000353513.1 ENSMUSG00000139484 (from geneSymbol) uc337lsi.1 uc337lsi.1 
ENSMUST00000353514.1 ENSMUSG00000139485 ENSMUST00000353514.1 ENSMUSG00000139485 (from geneSymbol) uc337lsj.1 uc337lsj.1 
ENSMUST00000353516.1 ENSMUSG00000139486 ENSMUST00000353516.1 ENSMUSG00000139486 (from geneSymbol) uc337lsl.1 uc337lsl.1 
ENSMUST00000353518.1 Gm26844 ENSMUST00000353518.1 Gm26844 (from geneSymbol) AK076966 uc337lsn.1 uc337lsn.1 
ENSMUST00000353526.1 ENSMUSG00000139487 ENSMUST00000353526.1 ENSMUSG00000139487 (from geneSymbol) uc337lsv.1 uc337lsv.1 
ENSMUST00000353527.1 ENSMUSG00000139488 ENSMUST00000353527.1 ENSMUSG00000139488 (from geneSymbol) uc337lsw.1 uc337lsw.1 
ENSMUST00000353529.1 Gm56889 ENSMUST00000353529.1 Gm56889 (from geneSymbol) uc337lsy.1 uc337lsy.1 
ENSMUST00000353531.1 ENSMUSG00000139489 ENSMUST00000353531.1 ENSMUSG00000139489 (from geneSymbol) uc337lta.1 uc337lta.1 
ENSMUST00000353532.1 ENSMUSG00000139490 ENSMUST00000353532.1 ENSMUSG00000139490 (from geneSymbol) uc337ltb.1 uc337ltb.1 
ENSMUST00000353552.1 4930405O22Rik ENSMUST00000353552.1 4930405O22Rik (from geneSymbol) KY467787 uc337ltv.1 uc337ltv.1 
ENSMUST00000353558.1 ENSMUSG00000139491 ENSMUST00000353558.1 ENSMUSG00000139491 (from geneSymbol) uc337lua.1 uc337lua.1 
ENSMUST00000353560.1 ENSMUSG00000139492 ENSMUST00000353560.1 ENSMUSG00000139492 (from geneSymbol) uc337luc.1 uc337luc.1 
ENSMUST00000353561.1 ENSMUSG00000139493 ENSMUST00000353561.1 ENSMUSG00000139493 (from geneSymbol) uc337lud.1 uc337lud.1 
ENSMUST00000353562.1 ENSMUSG00000139494 ENSMUST00000353562.1 ENSMUSG00000139494 (from geneSymbol) uc337lue.1 uc337lue.1 
ENSMUST00000353563.1 ENSMUSG00000139495 ENSMUST00000353563.1 ENSMUSG00000139495 (from geneSymbol) uc337luf.1 uc337luf.1 
ENSMUST00000353573.1 ENSMUSG00000139496 ENSMUST00000353573.1 ENSMUSG00000139496 (from geneSymbol) uc337lup.1 uc337lup.1 
ENSMUST00000353574.1 ENSMUSG00000139497 ENSMUST00000353574.1 ENSMUSG00000139497 (from geneSymbol) uc337luq.1 uc337luq.1 
ENSMUST00000353581.1 ENSMUSG00000139498 ENSMUST00000353581.1 ENSMUSG00000139498 (from geneSymbol) uc337lux.1 uc337lux.1 
ENSMUST00000353582.1 ENSMUSG00000139499 ENSMUST00000353582.1 ENSMUSG00000139499 (from geneSymbol) uc337luy.1 uc337luy.1 
ENSMUST00000353583.1 ENSMUSG00000139500 ENSMUST00000353583.1 ENSMUSG00000139500 (from geneSymbol) uc337luz.1 uc337luz.1 
ENSMUST00000353584.1 ENSMUSG00000139501 ENSMUST00000353584.1 ENSMUSG00000139501 (from geneSymbol) uc337lva.1 uc337lva.1 
ENSMUST00000353585.1 ENSMUSG00000139502 ENSMUST00000353585.1 ENSMUSG00000139502 (from geneSymbol) uc337lvb.1 uc337lvb.1 
ENSMUST00000353588.1 Gm39429 ENSMUST00000353588.1 predicted gene, 39429, transcript variant 3 (from RefSeq NR_168670.1) NR_168670 uc337lve.1 uc337lve.1 
ENSMUST00000353590.1 ENSMUSG00000121389 ENSMUST00000353590.1 ENSMUSG00000121389 (from geneSymbol) AK015427 uc337lvg.1 uc337lvg.1 
ENSMUST00000353591.1 ENSMUSG00000139504 ENSMUST00000353591.1 ENSMUSG00000139504 (from geneSymbol) uc337lvh.1 uc337lvh.1 
ENSMUST00000353594.1 ENSMUSG00000139505 ENSMUST00000353594.1 ENSMUSG00000139505 (from geneSymbol) uc337lvk.1 uc337lvk.1 
ENSMUST00000353599.1 ENSMUSG00000139506 ENSMUST00000353599.1 ENSMUSG00000139506 (from geneSymbol) uc337lvp.1 uc337lvp.1 
ENSMUST00000353601.1 ENSMUSG00000139507 ENSMUST00000353601.1 ENSMUSG00000139507 (from geneSymbol) uc337lvr.1 uc337lvr.1 
ENSMUST00000353602.1 ENSMUSG00000139508 ENSMUST00000353602.1 ENSMUSG00000139508 (from geneSymbol) uc337lvs.1 uc337lvs.1 
ENSMUST00000353603.1 ENSMUSG00000139509 ENSMUST00000353603.1 ENSMUSG00000139509 (from geneSymbol) uc337lvt.1 uc337lvt.1 
ENSMUST00000353605.1 ENSMUSG00000139510 ENSMUST00000353605.1 ENSMUSG00000139510 (from geneSymbol) uc337lvv.1 uc337lvv.1 
ENSMUST00000353606.1 ENSMUSG00000139511 ENSMUST00000353606.1 ENSMUSG00000139511 (from geneSymbol) uc337lvw.1 uc337lvw.1 
ENSMUST00000353607.1 Gm11466 ENSMUST00000353607.1 Gm11466 (from geneSymbol) uc337lvx.1 uc337lvx.1 
ENSMUST00000353624.1 ENSMUSG00000139512 ENSMUST00000353624.1 ENSMUSG00000139512 (from geneSymbol) uc337lwo.1 uc337lwo.1 
ENSMUST00000353626.1 ENSMUSG00000139513 ENSMUST00000353626.1 ENSMUSG00000139513 (from geneSymbol) uc337lwq.1 uc337lwq.1 
ENSMUST00000353627.1 Gm10548 ENSMUST00000353627.1 Gm10548 (from geneSymbol) AK160850 uc337lwr.1 uc337lwr.1 
ENSMUST00000353632.1 ENSMUSG00000139514 ENSMUST00000353632.1 ENSMUSG00000139514 (from geneSymbol) uc337lww.1 uc337lww.1 
ENSMUST00000353643.1 ENSMUSG00000139515 ENSMUST00000353643.1 ENSMUSG00000139515 (from geneSymbol) uc337lxh.1 uc337lxh.1 
ENSMUST00000353646.1 ENSMUSG00000139516 ENSMUST00000353646.1 ENSMUSG00000139516 (from geneSymbol) uc337lxk.1 uc337lxk.1 
ENSMUST00000353647.1 Gm30788 ENSMUST00000353647.1 Gm30788 (from geneSymbol) uc337lxl.1 uc337lxl.1 
ENSMUST00000353667.1 Gm3045 ENSMUST00000353667.1 Gm3045 (from geneSymbol) uc337lyf.1 uc337lyf.1 
ENSMUST00000353669.1 ENSMUSG00000139517 ENSMUST00000353669.1 ENSMUSG00000139517 (from geneSymbol) uc337lyh.1 uc337lyh.1 
ENSMUST00000353670.1 ENSMUSG00000139518 ENSMUST00000353670.1 ENSMUSG00000139518 (from geneSymbol) uc337lyi.1 uc337lyi.1 
ENSMUST00000353671.1 ENSMUSG00000139519 ENSMUST00000353671.1 ENSMUSG00000139519 (from geneSymbol) uc337lyj.1 uc337lyj.1 
ENSMUST00000353672.1 ENSMUSG00000139520 ENSMUST00000353672.1 ENSMUSG00000139520 (from geneSymbol) uc337lyk.1 uc337lyk.1 
ENSMUST00000353673.1 Gm16401 ENSMUST00000353673.1 Gm16401 (from geneSymbol) uc337lyl.1 uc337lyl.1 
ENSMUST00000353674.1 ENSMUSG00000139521 ENSMUST00000353674.1 ENSMUSG00000139521 (from geneSymbol) uc337lym.1 uc337lym.1 
ENSMUST00000353678.1 ENSMUSG00000139523 ENSMUST00000353678.1 ENSMUSG00000139523 (from geneSymbol) uc337lyo.1 uc337lyo.1 
ENSMUST00000353679.1 ENSMUSG00000139524 ENSMUST00000353679.1 ENSMUSG00000139524 (from geneSymbol) uc337lyp.1 uc337lyp.1 
ENSMUST00000353682.1 ENSMUSG00000139525 ENSMUST00000353682.1 ENSMUSG00000139525 (from geneSymbol) uc337lys.1 uc337lys.1 
ENSMUST00000353689.1 C730036E19Rik ENSMUST00000353689.1 C730036E19Rik (from geneSymbol) AK050309 uc337lyz.1 uc337lyz.1 
ENSMUST00000353696.1 ENSMUSG00000139526 ENSMUST00000353696.1 ENSMUSG00000139526 (from geneSymbol) uc337lzg.1 uc337lzg.1 
ENSMUST00000353699.1 ENSMUSG00000139527 ENSMUST00000353699.1 ENSMUSG00000139527 (from geneSymbol) uc337lzj.1 uc337lzj.1 
ENSMUST00000353700.1 ENSMUSG00000139528 ENSMUST00000353700.1 ENSMUSG00000139528 (from geneSymbol) uc337lzk.1 uc337lzk.1 
ENSMUST00000353701.1 ENSMUSG00000139529 ENSMUST00000353701.1 ENSMUSG00000139529 (from geneSymbol) uc337lzl.1 uc337lzl.1 
ENSMUST00000353702.1 ENSMUSG00000139530 ENSMUST00000353702.1 ENSMUSG00000139530 (from geneSymbol) uc337lzm.1 uc337lzm.1 
ENSMUST00000353704.1 ENSMUSG00000139531 ENSMUST00000353704.1 ENSMUSG00000139531 (from geneSymbol) uc337lzo.1 uc337lzo.1 
ENSMUST00000353705.1 Gm26581 ENSMUST00000353705.1 Gm26581 (from geneSymbol) uc337lzp.1 uc337lzp.1 
ENSMUST00000353712.1 Gm48193 ENSMUST00000353712.1 Gm48193 (from geneSymbol) uc337lzv.1 uc337lzv.1 
ENSMUST00000353717.1 ENSMUSG00000139532 ENSMUST00000353717.1 ENSMUSG00000139532 (from geneSymbol) uc337maa.1 uc337maa.1 
ENSMUST00000353718.1 Gm56811 ENSMUST00000353718.1 Gm56811 (from geneSymbol) uc337mab.1 uc337mab.1 
ENSMUST00000353721.1 ENSMUSG00000139533 ENSMUST00000353721.1 ENSMUSG00000139533 (from geneSymbol) uc337mae.1 uc337mae.1 
ENSMUST00000353725.1 ENSMUSG00000139534 ENSMUST00000353725.1 ENSMUSG00000139534 (from geneSymbol) uc337mai.1 uc337mai.1 
ENSMUST00000353729.1 Gm31615 ENSMUST00000353729.1 Gm31615 (from geneSymbol) uc337mam.1 uc337mam.1 
ENSMUST00000353736.1 ENSMUSG00000139535 ENSMUST00000353736.1 ENSMUSG00000139535 (from geneSymbol) uc337mat.1 uc337mat.1 
ENSMUST00000353737.1 ENSMUSG00000139536 ENSMUST00000353737.1 ENSMUSG00000139536 (from geneSymbol) uc337mau.1 uc337mau.1 
ENSMUST00000353738.1 ENSMUSG00000139537 ENSMUST00000353738.1 ENSMUSG00000139537 (from geneSymbol) uc337mav.1 uc337mav.1 
ENSMUST00000353739.1 ENSMUSG00000139538 ENSMUST00000353739.1 ENSMUSG00000139538 (from geneSymbol) uc337maw.1 uc337maw.1 
ENSMUST00000353740.1 4930562D21Rik ENSMUST00000353740.1 4930562D21Rik (from geneSymbol) AK016189 uc337max.1 uc337max.1 
ENSMUST00000353743.1 ENSMUSG00000139539 ENSMUST00000353743.1 ENSMUSG00000139539 (from geneSymbol) uc337mba.1 uc337mba.1 
ENSMUST00000353761.1 ENSMUSG00000139540 ENSMUST00000353761.1 ENSMUSG00000139540 (from geneSymbol) uc337mbs.1 uc337mbs.1 
ENSMUST00000353762.1 ENSMUSG00000139541 ENSMUST00000353762.1 ENSMUSG00000139541 (from geneSymbol) uc337mbt.1 uc337mbt.1 
ENSMUST00000353764.1 ENSMUSG00000139542 ENSMUST00000353764.1 ENSMUSG00000139542 (from geneSymbol) uc337mbv.1 uc337mbv.1 
ENSMUST00000353765.1 ENSMUSG00000139543 ENSMUST00000353765.1 ENSMUSG00000139543 (from geneSymbol) uc337mbw.1 uc337mbw.1 
ENSMUST00000353767.1 ENSMUSG00000139544 ENSMUST00000353767.1 ENSMUSG00000139544 (from geneSymbol) uc337mby.1 uc337mby.1 
ENSMUST00000353769.1 ENSMUSG00000139545 ENSMUST00000353769.1 ENSMUSG00000139545 (from geneSymbol) uc337mca.1 uc337mca.1 
ENSMUST00000353774.1 ENSMUSG00000139546 ENSMUST00000353774.1 ENSMUSG00000139546 (from geneSymbol) uc337mcf.1 uc337mcf.1 
ENSMUST00000353790.1 ENSMUSG00000139547 ENSMUST00000353790.1 ENSMUSG00000139547 (from geneSymbol) uc337mcv.1 uc337mcv.1 
ENSMUST00000353794.1 Gm35993 ENSMUST00000353794.1 Gm35993 (from geneSymbol) uc337mcz.1 uc337mcz.1 
ENSMUST00000353808.1 ENSMUSG00000139548 ENSMUST00000353808.1 ENSMUSG00000139548 (from geneSymbol) uc337mdn.1 uc337mdn.1 
ENSMUST00000353815.1 ENSMUSG00000139549 ENSMUST00000353815.1 ENSMUSG00000139549 (from geneSymbol) uc337mdu.1 uc337mdu.1 
ENSMUST00000353825.1 ENSMUSG00000139550 ENSMUST00000353825.1 ENSMUSG00000139550 (from geneSymbol) uc337mee.1 uc337mee.1 
ENSMUST00000353829.1 ENSMUSG00000139551 ENSMUST00000353829.1 ENSMUSG00000139551 (from geneSymbol) uc337mei.1 uc337mei.1 
ENSMUST00000353854.1 ENSMUSG00000139552 ENSMUST00000353854.1 ENSMUSG00000139552 (from geneSymbol) LF202981 uc337mfh.1 uc337mfh.1 
ENSMUST00000353855.1 ENSMUSG00000139553 ENSMUST00000353855.1 ENSMUSG00000139553 (from geneSymbol) uc337mfi.1 uc337mfi.1 
ENSMUST00000353861.1 Gm13203 ENSMUST00000353861.1 Gm13203 (from geneSymbol) uc337mfo.1 uc337mfo.1 
ENSMUST00000353867.1 ENSMUSG00000139554 ENSMUST00000353867.1 ENSMUSG00000139554 (from geneSymbol) uc337mfu.1 uc337mfu.1 
ENSMUST00000353868.1 ENSMUSG00000139555 ENSMUST00000353868.1 ENSMUSG00000139555 (from geneSymbol) uc337mfv.1 uc337mfv.1 
ENSMUST00000353869.1 ENSMUSG00000139556 ENSMUST00000353869.1 ENSMUSG00000139556 (from geneSymbol) uc337mfw.1 uc337mfw.1 
ENSMUST00000353871.1 ENSMUSG00000139557 ENSMUST00000353871.1 ENSMUSG00000139557 (from geneSymbol) uc337mfy.1 uc337mfy.1 
ENSMUST00000353872.1 ENSMUSG00000139558 ENSMUST00000353872.1 ENSMUSG00000139558 (from geneSymbol) uc337mfz.1 uc337mfz.1 
ENSMUST00000353874.1 Gm50356 ENSMUST00000353874.1 Gm50356 (from geneSymbol) uc337mgb.1 uc337mgb.1 
ENSMUST00000353904.1 ENSMUSG00000139559 ENSMUST00000353904.1 ENSMUSG00000139559 (from geneSymbol) uc337mhf.1 uc337mhf.1 
ENSMUST00000353906.1 ENSMUSG00000139560 ENSMUST00000353906.1 ENSMUSG00000139560 (from geneSymbol) uc337mhh.1 uc337mhh.1 
ENSMUST00000353907.1 4930541O19Rik ENSMUST00000353907.1 4930541O19Rik (from geneSymbol) AK076892 uc337mhi.1 uc337mhi.1 
ENSMUST00000353909.1 ENSMUSG00000139561 ENSMUST00000353909.1 ENSMUSG00000139561 (from geneSymbol) uc337mhk.1 uc337mhk.1 
ENSMUST00000353911.1 ENSMUSG00000139562 ENSMUST00000353911.1 ENSMUSG00000139562 (from geneSymbol) uc337mhm.1 uc337mhm.1 
ENSMUST00000353912.1 B9d1os ENSMUST00000353912.1 B9d1os (from geneSymbol) uc337mhn.1 uc337mhn.1 
ENSMUST00000353913.1 ENSMUSG00000139563 ENSMUST00000353913.1 ENSMUSG00000139563 (from geneSymbol) uc337mho.1 uc337mho.1 
ENSMUST00000353915.1 ENSMUSG00000139564 ENSMUST00000353915.1 ENSMUSG00000139564 (from geneSymbol) uc337mhq.1 uc337mhq.1 
ENSMUST00000353918.1 ENSMUSG00000139565 ENSMUST00000353918.1 ENSMUSG00000139565 (from geneSymbol) uc337mht.1 uc337mht.1 
ENSMUST00000353927.1 ENSMUSG00000139566 ENSMUST00000353927.1 ENSMUSG00000139566 (from geneSymbol) uc337mic.1 uc337mic.1 
ENSMUST00000353930.1 ENSMUSG00000139567 ENSMUST00000353930.1 ENSMUSG00000139567 (from geneSymbol) uc337mif.1 uc337mif.1 
ENSMUST00000353933.1 ENSMUSG00000139568 ENSMUST00000353933.1 ENSMUSG00000139568 (from geneSymbol) uc337mii.1 uc337mii.1 
ENSMUST00000353946.1 ENSMUSG00000139569 ENSMUST00000353946.1 ENSMUSG00000139569 (from geneSymbol) uc337miv.1 uc337miv.1 
ENSMUST00000353947.1 ENSMUSG00000139570 ENSMUST00000353947.1 ENSMUSG00000139570 (from geneSymbol) uc337miw.1 uc337miw.1 
ENSMUST00000353972.1 Gm46328 ENSMUST00000353972.1 Gm46328 (from geneSymbol) uc337mjv.1 uc337mjv.1 
ENSMUST00000353977.1 ENSMUSG00000139571 ENSMUST00000353977.1 ENSMUSG00000139571 (from geneSymbol) uc337mka.1 uc337mka.1 
ENSMUST00000353979.1 1700055D18Rik ENSMUST00000353979.1 1700055D18Rik (from geneSymbol) uc337mkc.1 uc337mkc.1 
ENSMUST00000353980.1 ENSMUSG00000139572 ENSMUST00000353980.1 ENSMUSG00000139572 (from geneSymbol) uc337mkd.1 uc337mkd.1 
ENSMUST00000353981.1 ENSMUSG00000139573 ENSMUST00000353981.1 ENSMUSG00000139573 (from geneSymbol) uc337mke.1 uc337mke.1 
ENSMUST00000353982.1 ENSMUSG00000139574 ENSMUST00000353982.1 ENSMUSG00000139574 (from geneSymbol) uc337mkf.1 uc337mkf.1 
ENSMUST00000353983.1 Mir124-2hg ENSMUST00000353983.1 Mir124-2hg (from geneSymbol) AK011787 uc337mkg.1 uc337mkg.1 
ENSMUST00000354028.1 ENSMUSG00000139575 ENSMUST00000354028.1 ENSMUSG00000139575 (from geneSymbol) uc337mlz.1 uc337mlz.1 
ENSMUST00000354030.1 ENSMUSG00000139576 ENSMUST00000354030.1 ENSMUSG00000139576 (from geneSymbol) uc337mmb.1 uc337mmb.1 
ENSMUST00000354032.1 ENSMUSG00000139577 ENSMUST00000354032.1 ENSMUSG00000139577 (from geneSymbol) uc337mmd.1 uc337mmd.1 
ENSMUST00000354036.1 ENSMUSG00000139579 ENSMUST00000354036.1 ENSMUSG00000139579 (from geneSymbol) uc337mmg.1 uc337mmg.1 
ENSMUST00000354039.1 ENSMUSG00000139580 ENSMUST00000354039.1 ENSMUSG00000139580 (from geneSymbol) uc337mmj.1 uc337mmj.1 
ENSMUST00000354040.1 ENSMUSG00000139581 ENSMUST00000354040.1 ENSMUSG00000139581 (from geneSymbol) uc337mmk.1 uc337mmk.1 
ENSMUST00000354043.1 2010110K18Rik ENSMUST00000354043.1 2010110K18Rik (from geneSymbol) AK008384 uc337mmn.1 uc337mmn.1 
ENSMUST00000354069.1 ENSMUSG00000139582 ENSMUST00000354069.1 ENSMUSG00000139582 (from geneSymbol) uc337mnn.1 uc337mnn.1 
ENSMUST00000354094.1 Gm26559 ENSMUST00000354094.1 Gm26559 (from geneSymbol) AK135852 uc337mom.1 uc337mom.1 
ENSMUST00000354104.1 ENSMUSG00000139583 ENSMUST00000354104.1 ENSMUSG00000139583 (from geneSymbol) uc337mow.1 uc337mow.1 
ENSMUST00000354105.1 ENSMUSG00000139584 ENSMUST00000354105.1 ENSMUSG00000139584 (from geneSymbol) uc337mox.1 uc337mox.1 
ENSMUST00000354106.1 Gm15201 ENSMUST00000354106.1 Gm15201 (from geneSymbol) AK136312 uc337moy.1 uc337moy.1 
ENSMUST00000354108.1 ENSMUSG00000139585 ENSMUST00000354108.1 ENSMUSG00000139585 (from geneSymbol) uc337mpa.1 uc337mpa.1 
ENSMUST00000354109.1 ENSMUSG00000139586 ENSMUST00000354109.1 ENSMUSG00000139586 (from geneSymbol) uc337mpb.1 uc337mpb.1 
ENSMUST00000354110.1 ENSMUSG00000139587 ENSMUST00000354110.1 ENSMUSG00000139587 (from geneSymbol) uc337mpc.1 uc337mpc.1 
ENSMUST00000354113.1 ENSMUSG00000139588 ENSMUST00000354113.1 ENSMUSG00000139588 (from geneSymbol) uc337mpf.1 uc337mpf.1 
ENSMUST00000354116.1 ENSMUSG00000139589 ENSMUST00000354116.1 ENSMUSG00000139589 (from geneSymbol) uc337mpi.1 uc337mpi.1 
ENSMUST00000354118.1 ENSMUSG00000139590 ENSMUST00000354118.1 ENSMUSG00000139590 (from geneSymbol) uc337mpk.1 uc337mpk.1 
ENSMUST00000354119.1 ENSMUSG00000139591 ENSMUST00000354119.1 ENSMUSG00000139591 (from geneSymbol) uc337mpl.1 uc337mpl.1 
ENSMUST00000354120.1 ENSMUSG00000139592 ENSMUST00000354120.1 ENSMUSG00000139592 (from geneSymbol) uc337mpm.1 uc337mpm.1 
ENSMUST00000354123.1 4930445N08Rik ENSMUST00000354123.1 4930445N08Rik (from geneSymbol) AK019615 uc337mpp.1 uc337mpp.1 
ENSMUST00000354126.1 ENSMUSG00000139593 ENSMUST00000354126.1 ENSMUSG00000139593 (from geneSymbol) uc337mps.1 uc337mps.1 
ENSMUST00000354127.1 ENSMUSG00000139594 ENSMUST00000354127.1 ENSMUSG00000139594 (from geneSymbol) uc337mpt.1 uc337mpt.1 
ENSMUST00000354128.1 ENSMUSG00000139595 ENSMUST00000354128.1 ENSMUSG00000139595 (from geneSymbol) uc337mpu.1 uc337mpu.1 
ENSMUST00000354131.1 Gm32926 ENSMUST00000354131.1 Gm32926 (from geneSymbol) AK139076 uc337mpx.1 uc337mpx.1 
ENSMUST00000354155.1 ENSMUSG00000139597 ENSMUST00000354155.1 ENSMUSG00000139597 (from geneSymbol) uc337mqu.1 uc337mqu.1 
ENSMUST00000354157.1 ENSMUSG00000139598 ENSMUST00000354157.1 ENSMUSG00000139598 (from geneSymbol) uc337mqw.1 uc337mqw.1 
ENSMUST00000354159.1 ENSMUSG00000139599 ENSMUST00000354159.1 ENSMUSG00000139599 (from geneSymbol) uc337mqy.1 uc337mqy.1 
ENSMUST00000354160.1 ENSMUSG00000139600 ENSMUST00000354160.1 ENSMUSG00000139600 (from geneSymbol) uc337mqz.1 uc337mqz.1 
ENSMUST00000354161.1 ENSMUSG00000139601 ENSMUST00000354161.1 ENSMUSG00000139601 (from geneSymbol) uc337mra.1 uc337mra.1 
ENSMUST00000354162.1 ENSMUSG00000139602 ENSMUST00000354162.1 ENSMUSG00000139602 (from geneSymbol) KY467891 uc337mrb.1 uc337mrb.1 
ENSMUST00000354166.1 ENSMUSG00000139603 ENSMUST00000354166.1 ENSMUSG00000139603 (from geneSymbol) uc337mrf.1 uc337mrf.1 
ENSMUST00000354169.1 ENSMUSG00000139604 ENSMUST00000354169.1 ENSMUSG00000139604 (from geneSymbol) uc337mri.1 uc337mri.1 
ENSMUST00000354170.1 ENSMUSG00000139605 ENSMUST00000354170.1 ENSMUSG00000139605 (from geneSymbol) uc337mrj.1 uc337mrj.1 
ENSMUST00000354172.1 ENSMUSG00000139606 ENSMUST00000354172.1 ENSMUSG00000139606 (from geneSymbol) uc337mrl.1 uc337mrl.1 
ENSMUST00000354173.1 ENSMUSG00000139607 ENSMUST00000354173.1 ENSMUSG00000139607 (from geneSymbol) uc337mrm.1 uc337mrm.1 
ENSMUST00000354176.1 ENSMUSG00000139608 ENSMUST00000354176.1 ENSMUSG00000139608 (from geneSymbol) uc337mrp.1 uc337mrp.1 
ENSMUST00000354178.1 Gm49969 ENSMUST00000354178.1 Gm49969 (from geneSymbol) AK038430 uc337mrr.1 uc337mrr.1 
ENSMUST00000354183.1 ENSMUSG00000139609 ENSMUST00000354183.1 ENSMUSG00000139609 (from geneSymbol) uc337mrw.1 uc337mrw.1 
ENSMUST00000354186.1 ENSMUSG00000139610 ENSMUST00000354186.1 ENSMUSG00000139610 (from geneSymbol) uc337mrz.1 uc337mrz.1 
ENSMUST00000354187.1 ENSMUSG00000139611 ENSMUST00000354187.1 ENSMUSG00000139611 (from geneSymbol) uc337msa.1 uc337msa.1 
ENSMUST00000354189.1 ENSMUSG00000139612 ENSMUST00000354189.1 ENSMUSG00000139612 (from geneSymbol) uc337msc.1 uc337msc.1 
ENSMUST00000354193.1 ENSMUSG00000139613 ENSMUST00000354193.1 ENSMUSG00000139613 (from geneSymbol) uc337msg.1 uc337msg.1 
ENSMUST00000354195.1 1700040K01Rik ENSMUST00000354195.1 1700040K01Rik (from geneSymbol) uc337msi.1 uc337msi.1 
ENSMUST00000354197.1 ENSMUSG00000139615 ENSMUST00000354197.1 ENSMUSG00000139615 (from geneSymbol) uc337msk.1 uc337msk.1 
ENSMUST00000354202.1 3110082J24Rik ENSMUST00000354202.1 3110082J24Rik (from geneSymbol) AK132123 uc337msn.1 uc337msn.1 
ENSMUST00000354206.1 ENSMUSG00000139617 ENSMUST00000354206.1 ENSMUSG00000139617 (from geneSymbol) AK162913 uc337msr.1 uc337msr.1 
ENSMUST00000354210.1 ENSMUSG00000139618 ENSMUST00000354210.1 ENSMUSG00000139618 (from geneSymbol) uc337msv.1 uc337msv.1 
ENSMUST00000354214.1 Gm35453 ENSMUST00000354214.1 Gm35453 (from geneSymbol) uc337msz.1 uc337msz.1 
ENSMUST00000354219.1 5730403I07Rik ENSMUST00000354219.1 5730403I07Rik (from geneSymbol) AK161639 uc337mte.1 uc337mte.1 
ENSMUST00000354233.1 Grip1os3 ENSMUST00000354233.1 Grip1os3 (from geneSymbol) AK144686 uc337mts.1 uc337mts.1 
ENSMUST00000354235.1 ENSMUSG00000139619 ENSMUST00000354235.1 ENSMUSG00000139619 (from geneSymbol) uc337mtu.1 uc337mtu.1 
ENSMUST00000354238.1 ENSMUSG00000139621 ENSMUST00000354238.1 ENSMUSG00000139621 (from geneSymbol) uc337mtx.1 uc337mtx.1 
ENSMUST00000354241.1 ENSMUSG00000139622 ENSMUST00000354241.1 ENSMUSG00000139622 (from geneSymbol) BC094408 uc337mua.1 uc337mua.1 
ENSMUST00000354244.1 ENSMUSG00000139623 ENSMUST00000354244.1 ENSMUSG00000139623 (from geneSymbol) uc337mud.1 uc337mud.1 
ENSMUST00000354245.1 ENSMUSG00000139624 ENSMUST00000354245.1 ENSMUSG00000139624 (from geneSymbol) uc337mue.1 uc337mue.1 
ENSMUST00000354248.1 ENSMUSG00000139625 ENSMUST00000354248.1 ENSMUSG00000139625 (from geneSymbol) uc337muh.1 uc337muh.1 
ENSMUST00000354249.1 ENSMUSG00000139626 ENSMUST00000354249.1 ENSMUSG00000139626 (from geneSymbol) uc337mui.1 uc337mui.1 
ENSMUST00000354250.1 ENSMUSG00000139627 ENSMUST00000354250.1 ENSMUSG00000139627 (from geneSymbol) uc337muj.1 uc337muj.1 
ENSMUST00000354257.1 Gm4577 ENSMUST00000354257.1 Gm4577 (from geneSymbol) uc337muq.1 uc337muq.1 
ENSMUST00000354258.1 ENSMUSG00000139628 ENSMUST00000354258.1 ENSMUSG00000139628 (from geneSymbol) uc337mur.1 uc337mur.1 
ENSMUST00000354260.1 ENSMUSG00000139629 ENSMUST00000354260.1 ENSMUSG00000139629 (from geneSymbol) uc337mut.1 uc337mut.1 
ENSMUST00000354262.1 ENSMUSG00000139630 ENSMUST00000354262.1 ENSMUSG00000139630 (from geneSymbol) uc337muv.1 uc337muv.1 
ENSMUST00000354264.1 ENSMUSG00000139631 ENSMUST00000354264.1 ENSMUSG00000139631 (from geneSymbol) uc337mux.1 uc337mux.1 
ENSMUST00000354265.1 ENSMUSG00000139632 ENSMUST00000354265.1 ENSMUSG00000139632 (from geneSymbol) uc337muy.1 uc337muy.1 
ENSMUST00000354266.1 ENSMUSG00000139633 ENSMUST00000354266.1 ENSMUSG00000139633 (from geneSymbol) uc337muz.1 uc337muz.1 
ENSMUST00000354269.1 Gm34408 ENSMUST00000354269.1 Gm34408 (from geneSymbol) uc337mvc.1 uc337mvc.1 
ENSMUST00000354276.1 4930478M13Rik ENSMUST00000354276.1 4930478M13Rik (from geneSymbol) AK015589 uc337mvj.1 uc337mvj.1 
ENSMUST00000354285.1 ENSMUSG00000139634 ENSMUST00000354285.1 ENSMUSG00000139634 (from geneSymbol) uc337mvs.1 uc337mvs.1 
ENSMUST00000354286.1 ENSMUSG00000139635 ENSMUST00000354286.1 ENSMUSG00000139635 (from geneSymbol) uc337mvt.1 uc337mvt.1 
ENSMUST00000354291.1 ENSMUSG00000139636 ENSMUST00000354291.1 ENSMUSG00000139636 (from geneSymbol) uc337mvy.1 uc337mvy.1 
ENSMUST00000354293.1 ENSMUSG00000139638 ENSMUST00000354293.1 ENSMUSG00000139638 (from geneSymbol) uc337mvz.1 uc337mvz.1 
ENSMUST00000354294.1 ENSMUSG00000139639 ENSMUST00000354294.1 ENSMUSG00000139639 (from geneSymbol) uc337mwa.1 uc337mwa.1 
ENSMUST00000354295.1 ENSMUSG00000139640 ENSMUST00000354295.1 ENSMUSG00000139640 (from geneSymbol) uc337mwb.1 uc337mwb.1 
ENSMUST00000354296.1 4930500A05Rik ENSMUST00000354296.1 4930500A05Rik (from geneSymbol) AK015653 uc337mwc.1 uc337mwc.1 
ENSMUST00000354300.1 ENSMUSG00000139641 ENSMUST00000354300.1 ENSMUSG00000139641 (from geneSymbol) uc337mwg.1 uc337mwg.1 
ENSMUST00000354301.1 ENSMUSG00000139642 ENSMUST00000354301.1 ENSMUSG00000139642 (from geneSymbol) uc337mwh.1 uc337mwh.1 
ENSMUST00000354304.1 ENSMUSG00000139643 ENSMUST00000354304.1 ENSMUSG00000139643 (from geneSymbol) uc337mwk.1 uc337mwk.1 
ENSMUST00000354305.1 ENSMUSG00000139644 ENSMUST00000354305.1 ENSMUSG00000139644 (from geneSymbol) uc337mwl.1 uc337mwl.1 
ENSMUST00000354328.1 ENSMUSG00000139645 ENSMUST00000354328.1 ENSMUSG00000139645 (from geneSymbol) uc337mxi.1 uc337mxi.1 
ENSMUST00000354330.1 Gm13330 ENSMUST00000354330.1 Gm13330 (from geneSymbol) uc337mxk.1 uc337mxk.1 
ENSMUST00000354332.1 ENSMUSG00000139646 ENSMUST00000354332.1 ENSMUSG00000139646 (from geneSymbol) uc337mxm.1 uc337mxm.1 
ENSMUST00000354334.1 ENSMUSG00000139647 ENSMUST00000354334.1 ENSMUSG00000139647 (from geneSymbol) uc337mxo.1 uc337mxo.1 
ENSMUST00000354338.1 ENSMUSG00000139648 ENSMUST00000354338.1 ENSMUSG00000139648 (from geneSymbol) uc337mxs.1 uc337mxs.1 
ENSMUST00000354339.1 ENSMUSG00000139649 ENSMUST00000354339.1 ENSMUSG00000139649 (from geneSymbol) uc337mxt.1 uc337mxt.1 
ENSMUST00000354340.1 Gsdmcl2 ENSMUST00000354340.1 Gsdmcl2 (from geneSymbol) AK019629 uc337mxu.1 uc337mxu.1 
ENSMUST00000354357.1 ENSMUSG00000139650 ENSMUST00000354357.1 ENSMUSG00000139650 (from geneSymbol) uc337myl.1 uc337myl.1 
ENSMUST00000354367.1 ENSMUSG00000139651 ENSMUST00000354367.1 ENSMUSG00000139651 (from geneSymbol) uc337myv.1 uc337myv.1 
ENSMUST00000354380.1 4930461C15Rik ENSMUST00000354380.1 4930461C15Rik (from geneSymbol) AK015492 uc337mzi.1 uc337mzi.1 
ENSMUST00000354386.1 ENSMUSG00000139652 ENSMUST00000354386.1 ENSMUSG00000139652 (from geneSymbol) uc337mzo.1 uc337mzo.1 
ENSMUST00000354387.1 ENSMUSG00000139653 ENSMUST00000354387.1 ENSMUSG00000139653 (from geneSymbol) uc337mzp.1 uc337mzp.1 
ENSMUST00000354388.1 ENSMUSG00000139654 ENSMUST00000354388.1 ENSMUSG00000139654 (from geneSymbol) uc337mzq.1 uc337mzq.1 
ENSMUST00000354389.1 ENSMUSG00000139655 ENSMUST00000354389.1 ENSMUSG00000139655 (from geneSymbol) uc337mzr.1 uc337mzr.1 
ENSMUST00000354393.1 1700025F24Rik ENSMUST00000354393.1 1700025F24Rik (from geneSymbol) AK006336 uc337mzv.1 uc337mzv.1 
ENSMUST00000354428.1 Gm46658 ENSMUST00000354428.1 Gm46658 (from geneSymbol) uc337nbe.1 uc337nbe.1 
ENSMUST00000354429.1 ENSMUSG00000139656 ENSMUST00000354429.1 ENSMUSG00000139656 (from geneSymbol) uc337nbf.1 uc337nbf.1 
ENSMUST00000354431.1 ENSMUSG00000139657 ENSMUST00000354431.1 ENSMUSG00000139657 (from geneSymbol) uc337nbh.1 uc337nbh.1 
ENSMUST00000354434.1 ENSMUSG00000139658 ENSMUST00000354434.1 ENSMUSG00000139658 (from geneSymbol) uc337nbk.1 uc337nbk.1 
ENSMUST00000354441.1 ENSMUSG00000139659 ENSMUST00000354441.1 ENSMUSG00000139659 (from geneSymbol) uc337nbr.1 uc337nbr.1 
ENSMUST00000354449.1 ENSMUSG00000139660 ENSMUST00000354449.1 ENSMUSG00000139660 (from geneSymbol) uc337nbz.1 uc337nbz.1 
ENSMUST00000354458.1 ENSMUSG00000139661 ENSMUST00000354458.1 ENSMUSG00000139661 (from geneSymbol) uc337nci.1 uc337nci.1 
ENSMUST00000354461.1 ENSMUSG00000139662 ENSMUST00000354461.1 ENSMUSG00000139662 (from geneSymbol) uc337ncl.1 uc337ncl.1 
ENSMUST00000354462.1 ENSMUSG00000139663 ENSMUST00000354462.1 ENSMUSG00000139663 (from geneSymbol) uc337ncm.1 uc337ncm.1 
ENSMUST00000354464.1 ENSMUSG00000139664 ENSMUST00000354464.1 ENSMUSG00000139664 (from geneSymbol) uc337nco.1 uc337nco.1 
ENSMUST00000354468.1 ENSMUSG00000139665 ENSMUST00000354468.1 ENSMUSG00000139665 (from geneSymbol) uc337ncs.1 uc337ncs.1 
ENSMUST00000354473.1 ENSMUSG00000139667 ENSMUST00000354473.1 ENSMUSG00000139667 (from geneSymbol) uc337ncw.1 uc337ncw.1 
ENSMUST00000354476.1 ENSMUSG00000139668 ENSMUST00000354476.1 ENSMUSG00000139668 (from geneSymbol) uc337ncz.1 uc337ncz.1 
ENSMUST00000354477.1 ENSMUSG00000139669 ENSMUST00000354477.1 ENSMUSG00000139669 (from geneSymbol) uc337nda.1 uc337nda.1 
ENSMUST00000354480.1 ENSMUSG00000139670 ENSMUST00000354480.1 ENSMUSG00000139670 (from geneSymbol) uc337ndd.1 uc337ndd.1 
ENSMUST00000354483.1 ENSMUSG00000139672 ENSMUST00000354483.1 ENSMUSG00000139672 (from geneSymbol) uc337nde.1 uc337nde.1 
ENSMUST00000354487.1 ENSMUSG00000139673 ENSMUST00000354487.1 ENSMUSG00000139673 (from geneSymbol) uc337ndi.1 uc337ndi.1 
ENSMUST00000354500.1 ENSMUSG00000139674 ENSMUST00000354500.1 ENSMUSG00000139674 (from geneSymbol) uc337ndv.1 uc337ndv.1 
ENSMUST00000354511.1 Gm31520 ENSMUST00000354511.1 Gm31520 (from geneSymbol) AK052921 uc337neg.1 uc337neg.1 
ENSMUST00000354516.1 Ube2d-ps ENSMUST00000354516.1 Ube2d-ps (from geneSymbol) AK005556 uc337nek.1 uc337nek.1 
ENSMUST00000354591.1 Gm45474 ENSMUST00000354591.1 Gm45474 (from geneSymbol) uc337nhg.1 uc337nhg.1 
ENSMUST00000354592.1 ENSMUSG00000139675 ENSMUST00000354592.1 ENSMUSG00000139675 (from geneSymbol) uc337nhh.1 uc337nhh.1 
ENSMUST00000354593.1 Gm13372 ENSMUST00000354593.1 Gm13372 (from geneSymbol) AK158259 uc337nhi.1 uc337nhi.1 
ENSMUST00000354599.1 1700046C09Rik ENSMUST00000354599.1 1700046C09Rik (from geneSymbol) AK006701 uc337nho.1 uc337nho.1 
ENSMUST00000354632.1 ENSMUSG00000139676 ENSMUST00000354632.1 ENSMUSG00000139676 (from geneSymbol) uc337niv.1 uc337niv.1 
ENSMUST00000354636.1 ENSMUSG00000139677 ENSMUST00000354636.1 ENSMUSG00000139677 (from geneSymbol) uc337niz.1 uc337niz.1 
ENSMUST00000354638.1 ENSMUSG00000139678 ENSMUST00000354638.1 ENSMUSG00000139678 (from geneSymbol) uc337njb.1 uc337njb.1 
ENSMUST00000354639.1 ENSMUSG00000139679 ENSMUST00000354639.1 ENSMUSG00000139679 (from geneSymbol) uc337njc.1 uc337njc.1 
ENSMUST00000354641.1 ENSMUSG00000139680 ENSMUST00000354641.1 ENSMUSG00000139680 (from geneSymbol) uc337nje.1 uc337nje.1 
ENSMUST00000354644.1 ENSMUSG00000139681 ENSMUST00000354644.1 ENSMUSG00000139681 (from geneSymbol) uc337njh.1 uc337njh.1 
ENSMUST00000354655.1 ENSMUSG00000139682 ENSMUST00000354655.1 ENSMUSG00000139682 (from geneSymbol) uc337njs.1 uc337njs.1 
ENSMUST00000354656.1 Gm31223 ENSMUST00000354656.1 Gm31223 (from geneSymbol) AK028622 uc337njt.1 uc337njt.1 
ENSMUST00000354667.1 ENSMUSG00000139684 ENSMUST00000354667.1 ENSMUSG00000139684 (from geneSymbol) uc337nkd.1 uc337nkd.1 
ENSMUST00000354671.1 4930588G17Rik ENSMUST00000354671.1 4930588G17Rik (from geneSymbol) AK016366 uc337nkh.1 uc337nkh.1 
ENSMUST00000354673.1 ENSMUSG00000139685 ENSMUST00000354673.1 ENSMUSG00000139685 (from geneSymbol) uc337nkj.1 uc337nkj.1 
ENSMUST00000354674.1 ENSMUSG00000139686 ENSMUST00000354674.1 ENSMUSG00000139686 (from geneSymbol) uc337nkk.1 uc337nkk.1 
ENSMUST00000354676.1 ENSMUSG00000139687 ENSMUST00000354676.1 ENSMUSG00000139687 (from geneSymbol) uc337nkm.1 uc337nkm.1 
ENSMUST00000354678.1 ENSMUSG00000139688 ENSMUST00000354678.1 ENSMUSG00000139688 (from geneSymbol) uc337nko.1 uc337nko.1 
ENSMUST00000354681.1 ENSMUSG00000139689 ENSMUST00000354681.1 ENSMUSG00000139689 (from geneSymbol) uc337nkr.1 uc337nkr.1 
ENSMUST00000354683.1 ENSMUSG00000139690 ENSMUST00000354683.1 ENSMUSG00000139690 (from geneSymbol) uc337nkt.1 uc337nkt.1 
ENSMUST00000354684.1 ENSMUSG00000139691 ENSMUST00000354684.1 ENSMUSG00000139691 (from geneSymbol) uc337nku.1 uc337nku.1 
ENSMUST00000354686.1 ENSMUSG00000139692 ENSMUST00000354686.1 ENSMUSG00000139692 (from geneSymbol) uc337nkw.1 uc337nkw.1 
ENSMUST00000354688.1 ENSMUSG00000139693 ENSMUST00000354688.1 ENSMUSG00000139693 (from geneSymbol) uc337nky.1 uc337nky.1 
ENSMUST00000354691.1 ENSMUSG00000139694 ENSMUST00000354691.1 ENSMUSG00000139694 (from geneSymbol) uc337nlb.1 uc337nlb.1 
ENSMUST00000354692.1 ENSMUSG00000139695 ENSMUST00000354692.1 ENSMUSG00000139695 (from geneSymbol) uc337nlc.1 uc337nlc.1 
ENSMUST00000354696.1 ENSMUSG00000139696 ENSMUST00000354696.1 ENSMUSG00000139696 (from geneSymbol) uc337nlg.1 uc337nlg.1 
ENSMUST00000354702.1 ENSMUSG00000139697 ENSMUST00000354702.1 ENSMUSG00000139697 (from geneSymbol) uc337nlm.1 uc337nlm.1 
ENSMUST00000354706.1 ENSMUSG00000139698 ENSMUST00000354706.1 ENSMUSG00000139698 (from geneSymbol) uc337nlq.1 uc337nlq.1 
ENSMUST00000354708.1 Gm47819 ENSMUST00000354708.1 Gm47819 (from geneSymbol) uc337nls.1 uc337nls.1 
ENSMUST00000354714.1 ENSMUSG00000139699 ENSMUST00000354714.1 ENSMUSG00000139699 (from geneSymbol) uc337nly.1 uc337nly.1 
ENSMUST00000354715.1 ENSMUSG00000139700 ENSMUST00000354715.1 ENSMUSG00000139700 (from geneSymbol) uc337nlz.1 uc337nlz.1 
ENSMUST00000354719.1 ENSMUSG00000139702 ENSMUST00000354719.1 ENSMUSG00000139702 (from geneSymbol) uc337nma.1 uc337nma.1 
ENSMUST00000354720.1 Gm28888 ENSMUST00000354720.1 Gm28888 (from geneSymbol) uc337nmb.1 uc337nmb.1 
ENSMUST00000354723.1 ENSMUSG00000139703 ENSMUST00000354723.1 ENSMUSG00000139703 (from geneSymbol) uc337nme.1 uc337nme.1 
ENSMUST00000354728.1 Gm27192 ENSMUST00000354728.1 Gm27192 (from geneSymbol) uc337nmj.1 uc337nmj.1 
ENSMUST00000354731.1 ENSMUSG00000139704 ENSMUST00000354731.1 ENSMUSG00000139704 (from geneSymbol) uc337nmm.1 uc337nmm.1 
ENSMUST00000354732.1 ENSMUSG00000139705 ENSMUST00000354732.1 ENSMUSG00000139705 (from geneSymbol) uc337nmn.1 uc337nmn.1 
ENSMUST00000354759.1 ENSMUSG00000139706 ENSMUST00000354759.1 ENSMUSG00000139706 (from geneSymbol) uc337nnl.1 uc337nnl.1 
ENSMUST00000354860.1 ENSMUSG00000139707 ENSMUST00000354860.1 ENSMUSG00000139707 (from geneSymbol) uc337nri.1 uc337nri.1 
ENSMUST00000354864.1 ENSMUSG00000139708 ENSMUST00000354864.1 ENSMUSG00000139708 (from geneSymbol) uc337nrm.1 uc337nrm.1 
ENSMUST00000354875.1 Gm40190 ENSMUST00000354875.1 Gm40190 (from geneSymbol) uc337nrx.1 uc337nrx.1 
ENSMUST00000354877.1 ENSMUSG00000139710 ENSMUST00000354877.1 ENSMUSG00000139710 (from geneSymbol) uc337nry.1 uc337nry.1 
ENSMUST00000354883.1 Gm31816 ENSMUST00000354883.1 Gm31816 (from geneSymbol) uc337nse.1 uc337nse.1 
ENSMUST00000354928.1 ENSMUSG00000139711 ENSMUST00000354928.1 ENSMUSG00000139711 (from geneSymbol) uc337ntx.1 uc337ntx.1 
ENSMUST00000354932.1 ENSMUSG00000139712 ENSMUST00000354932.1 ENSMUSG00000139712 (from geneSymbol) uc337nub.1 uc337nub.1 
ENSMUST00000354933.1 ENSMUSG00000139713 ENSMUST00000354933.1 ENSMUSG00000139713 (from geneSymbol) uc337nuc.1 uc337nuc.1 
ENSMUST00000354935.1 ENSMUSG00000139714 ENSMUST00000354935.1 ENSMUSG00000139714 (from geneSymbol) uc337nue.1 uc337nue.1 
ENSMUST00000354936.1 ENSMUSG00000139715 ENSMUST00000354936.1 ENSMUSG00000139715 (from geneSymbol) uc337nuf.1 uc337nuf.1 
ENSMUST00000354940.1 ENSMUSG00000139716 ENSMUST00000354940.1 ENSMUSG00000139716 (from geneSymbol) uc337nuj.1 uc337nuj.1 
ENSMUST00000354949.1 ENSMUSG00000139717 ENSMUST00000354949.1 ENSMUSG00000139717 (from geneSymbol) uc337nus.1 uc337nus.1 
ENSMUST00000354951.1 ENSMUSG00000139718 ENSMUST00000354951.1 ENSMUSG00000139718 (from geneSymbol) uc337nuu.1 uc337nuu.1 
ENSMUST00000354953.1 ENSMUSG00000139719 ENSMUST00000354953.1 ENSMUSG00000139719 (from geneSymbol) uc337nuw.1 uc337nuw.1 
ENSMUST00000354956.1 ENSMUSG00000139720 ENSMUST00000354956.1 ENSMUSG00000139720 (from geneSymbol) uc337nuz.1 uc337nuz.1 
ENSMUST00000354962.1 ENSMUSG00000139721 ENSMUST00000354962.1 ENSMUSG00000139721 (from geneSymbol) uc337nvf.1 uc337nvf.1 
ENSMUST00000354967.1 ENSMUSG00000139722 ENSMUST00000354967.1 ENSMUSG00000139722 (from geneSymbol) AK146672 uc337nvk.1 uc337nvk.1 
ENSMUST00000354969.1 ENSMUSG00000139723 ENSMUST00000354969.1 ENSMUSG00000139723 (from geneSymbol) uc337nvm.1 uc337nvm.1 
ENSMUST00000354970.1 ENSMUSG00000139724 ENSMUST00000354970.1 ENSMUSG00000139724 (from geneSymbol) uc337nvn.1 uc337nvn.1 
ENSMUST00000355007.1 ENSMUSG00000139725 ENSMUST00000355007.1 ENSMUSG00000139725 (from geneSymbol) uc337nwy.1 uc337nwy.1 
ENSMUST00000355008.1 ENSMUSG00000139726 ENSMUST00000355008.1 ENSMUSG00000139726 (from geneSymbol) uc337nwz.1 uc337nwz.1 
ENSMUST00000355009.1 ENSMUSG00000139727 ENSMUST00000355009.1 ENSMUSG00000139727 (from geneSymbol) DJ442760 uc337nxa.1 uc337nxa.1 
ENSMUST00000355016.1 ENSMUSG00000139728 ENSMUST00000355016.1 ENSMUSG00000139728 (from geneSymbol) uc337nxh.1 uc337nxh.1 
ENSMUST00000355017.1 ENSMUSG00000139729 ENSMUST00000355017.1 ENSMUSG00000139729 (from geneSymbol) uc337nxi.1 uc337nxi.1 
ENSMUST00000355018.1 Gm34853 ENSMUST00000355018.1 Gm34853 (from geneSymbol) uc337nxj.1 uc337nxj.1 
ENSMUST00000355028.1 ENSMUSG00000139730 ENSMUST00000355028.1 ENSMUSG00000139730 (from geneSymbol) uc337nxt.1 uc337nxt.1 
ENSMUST00000355029.1 ENSMUSG00000139731 ENSMUST00000355029.1 ENSMUSG00000139731 (from geneSymbol) uc337nxu.1 uc337nxu.1 
ENSMUST00000355030.1 ENSMUSG00000139732 ENSMUST00000355030.1 ENSMUSG00000139732 (from geneSymbol) uc337nxv.1 uc337nxv.1 
ENSMUST00000355045.1 ENSMUSG00000139733 ENSMUST00000355045.1 ENSMUSG00000139733 (from geneSymbol) uc337nyk.1 uc337nyk.1 
ENSMUST00000355046.1 ENSMUSG00000139734 ENSMUST00000355046.1 ENSMUSG00000139734 (from geneSymbol) uc337nyl.1 uc337nyl.1 
ENSMUST00000355049.1 ENSMUSG00000139735 ENSMUST00000355049.1 ENSMUSG00000139735 (from geneSymbol) uc337nyo.1 uc337nyo.1 
ENSMUST00000355051.1 ENSMUSG00000139737 ENSMUST00000355051.1 ENSMUSG00000139737 (from geneSymbol) uc337nyp.1 uc337nyp.1 
ENSMUST00000355052.1 ENSMUSG00000139738 ENSMUST00000355052.1 ENSMUSG00000139738 (from geneSymbol) uc337nyq.1 uc337nyq.1 
ENSMUST00000355061.1 B230398E01Rik ENSMUST00000355061.1 B230398E01Rik (from geneSymbol) AK046489 uc337nyz.1 uc337nyz.1 
ENSMUST00000355083.1 ENSMUSG00000139739 ENSMUST00000355083.1 ENSMUSG00000139739 (from geneSymbol) uc337nzv.1 uc337nzv.1 
ENSMUST00000355084.1 ENSMUSG00000139740 ENSMUST00000355084.1 ENSMUSG00000139740 (from geneSymbol) uc337nzw.1 uc337nzw.1 
ENSMUST00000355087.1 ENSMUSG00000139741 ENSMUST00000355087.1 ENSMUSG00000139741 (from geneSymbol) uc337nzz.1 uc337nzz.1 
ENSMUST00000355089.1 ENSMUSG00000139742 ENSMUST00000355089.1 ENSMUSG00000139742 (from geneSymbol) uc337oab.1 uc337oab.1 
ENSMUST00000355126.1 ENSMUSG00000139743 ENSMUST00000355126.1 ENSMUSG00000139743 (from geneSymbol) uc337obm.1 uc337obm.1 
ENSMUST00000355127.1 ENSMUSG00000139744 ENSMUST00000355127.1 ENSMUSG00000139744 (from geneSymbol) uc337obn.1 uc337obn.1 
ENSMUST00000355128.1 ENSMUSG00000139745 ENSMUST00000355128.1 ENSMUSG00000139745 (from geneSymbol) uc337obo.1 uc337obo.1 
ENSMUST00000355129.1 4930519D14Rik ENSMUST00000355129.1 4930519D14Rik (from geneSymbol) AK015838 uc337obp.1 uc337obp.1 
ENSMUST00000355142.1 ENSMUSG00000139746 ENSMUST00000355142.1 ENSMUSG00000139746 (from geneSymbol) LF201837 uc337occ.1 uc337occ.1 
ENSMUST00000355143.1 ENSMUSG00000139747 ENSMUST00000355143.1 ENSMUSG00000139747 (from geneSymbol) uc337ocd.1 uc337ocd.1 
ENSMUST00000355148.1 1700026J12Rik ENSMUST00000355148.1 RIKEN cDNA 1700026J12 gene, transcript variant 2 (from RefSeq NR_166908.1) NR_166908 uc337oci.1 uc337oci.1 
ENSMUST00000355164.1 A430105J06Rik ENSMUST00000355164.1 RIKEN cDNA A430105J06 gene, transcript variant 2 (from RefSeq NR_190099.1) NR_190099 uc337ocy.1 uc337ocy.1 
ENSMUST00000355167.1 Hoxb5os ENSMUST00000355167.1 Hoxb5os (from geneSymbol) AK002860 uc337odb.1 uc337odb.1 
ENSMUST00000355221.1 ENSMUSG00000139748 ENSMUST00000355221.1 ENSMUSG00000139748 (from geneSymbol) uc337ofd.1 uc337ofd.1 
ENSMUST00000355227.1 ENSMUSG00000139749 ENSMUST00000355227.1 ENSMUSG00000139749 (from geneSymbol) uc337ofj.1 uc337ofj.1 
ENSMUST00000355228.1 ENSMUSG00000139750 ENSMUST00000355228.1 ENSMUSG00000139750 (from geneSymbol) uc337ofk.1 uc337ofk.1 
ENSMUST00000355233.1 ENSMUSG00000139751 ENSMUST00000355233.1 ENSMUSG00000139751 (from geneSymbol) uc337ofp.1 uc337ofp.1 
ENSMUST00000355241.1 ENSMUSG00000139752 ENSMUST00000355241.1 ENSMUSG00000139752 (from geneSymbol) uc337ofx.1 uc337ofx.1 
ENSMUST00000355256.1 Gm17613 ENSMUST00000355256.1 Gm17613 (from geneSymbol) EU234014 uc337ogm.1 uc337ogm.1 
ENSMUST00000355257.1 ENSMUSG00000139753 ENSMUST00000355257.1 ENSMUSG00000139753 (from geneSymbol) uc337ogn.1 uc337ogn.1 
ENSMUST00000355258.1 D330023K18Rik ENSMUST00000355258.1 D330023K18Rik (from geneSymbol) KY467846 uc337ogo.1 uc337ogo.1 
ENSMUST00000355271.1 ENSMUSG00000139754 ENSMUST00000355271.1 ENSMUSG00000139754 (from geneSymbol) uc337ohb.1 uc337ohb.1 
ENSMUST00000355272.1 ENSMUSG00000139755 ENSMUST00000355272.1 ENSMUSG00000139755 (from geneSymbol) uc337ohc.1 uc337ohc.1 
ENSMUST00000355273.1 ENSMUSG00000139756 ENSMUST00000355273.1 ENSMUSG00000139756 (from geneSymbol) uc337ohd.1 uc337ohd.1 
ENSMUST00000355275.1 ENSMUSG00000139757 ENSMUST00000355275.1 ENSMUSG00000139757 (from geneSymbol) uc337ohf.1 uc337ohf.1 
ENSMUST00000355278.1 ENSMUSG00000139758 ENSMUST00000355278.1 ENSMUSG00000139758 (from geneSymbol) uc337ohi.1 uc337ohi.1 
ENSMUST00000355279.1 ENSMUSG00000139759 ENSMUST00000355279.1 ENSMUSG00000139759 (from geneSymbol) uc337ohj.1 uc337ohj.1 
ENSMUST00000355281.1 ENSMUSG00000139760 ENSMUST00000355281.1 ENSMUSG00000139760 (from geneSymbol) uc337ohl.1 uc337ohl.1 
ENSMUST00000355286.1 ENSMUSG00000139761 ENSMUST00000355286.1 ENSMUSG00000139761 (from geneSymbol) uc337ohq.1 uc337ohq.1 
ENSMUST00000355287.1 ENSMUSG00000139762 ENSMUST00000355287.1 ENSMUSG00000139762 (from geneSymbol) AK085349 uc337ohr.1 uc337ohr.1 
ENSMUST00000355288.1 Gm14199 ENSMUST00000355288.1 Gm14199 (from geneSymbol) uc337ohs.1 uc337ohs.1 
ENSMUST00000355293.1 ENSMUSG00000139763 ENSMUST00000355293.1 ENSMUSG00000139763 (from geneSymbol) uc337ohx.1 uc337ohx.1 
ENSMUST00000355296.1 ENSMUSG00000139764 ENSMUST00000355296.1 ENSMUSG00000139764 (from geneSymbol) uc337oia.1 uc337oia.1 
ENSMUST00000355305.1 ENSMUSG00000139765 ENSMUST00000355305.1 ENSMUSG00000139765 (from geneSymbol) uc337oij.1 uc337oij.1 
ENSMUST00000355306.1 ENSMUSG00000139766 ENSMUST00000355306.1 ENSMUSG00000139766 (from geneSymbol) uc337oik.1 uc337oik.1 
ENSMUST00000355309.1 ENSMUSG00000139767 ENSMUST00000355309.1 ENSMUSG00000139767 (from geneSymbol) uc337oin.1 uc337oin.1 
ENSMUST00000355314.1 ENSMUSG00000139768 ENSMUST00000355314.1 ENSMUSG00000139768 (from geneSymbol) uc337ois.1 uc337ois.1 
ENSMUST00000355324.1 ENSMUSG00000139769 ENSMUST00000355324.1 ENSMUSG00000139769 (from geneSymbol) uc337ojc.1 uc337ojc.1 
ENSMUST00000355325.1 ENSMUSG00000139770 ENSMUST00000355325.1 ENSMUSG00000139770 (from geneSymbol) uc337ojd.1 uc337ojd.1 
ENSMUST00000355328.1 ENSMUSG00000139771 ENSMUST00000355328.1 ENSMUSG00000139771 (from geneSymbol) uc337ojg.1 uc337ojg.1 
ENSMUST00000355329.1 ENSMUSG00000139772 ENSMUST00000355329.1 ENSMUSG00000139772 (from geneSymbol) uc337ojh.1 uc337ojh.1 
ENSMUST00000355330.1 ENSMUSG00000139773 ENSMUST00000355330.1 ENSMUSG00000139773 (from geneSymbol) uc337oji.1 uc337oji.1 
ENSMUST00000355331.1 ENSMUSG00000139774 ENSMUST00000355331.1 ENSMUSG00000139774 (from geneSymbol) uc337ojj.1 uc337ojj.1 
ENSMUST00000355334.1 ENSMUSG00000139775 ENSMUST00000355334.1 ENSMUSG00000139775 (from geneSymbol) uc337ojm.1 uc337ojm.1 
ENSMUST00000355335.1 ENSMUSG00000139776 ENSMUST00000355335.1 ENSMUSG00000139776 (from geneSymbol) uc337ojn.1 uc337ojn.1 
ENSMUST00000355336.1 ENSMUSG00000139777 ENSMUST00000355336.1 ENSMUSG00000139777 (from geneSymbol) uc337ojo.1 uc337ojo.1 
ENSMUST00000355337.1 ENSMUSG00000139778 ENSMUST00000355337.1 ENSMUSG00000139778 (from geneSymbol) AK048719 uc337ojp.1 uc337ojp.1 
ENSMUST00000355338.1 ENSMUSG00000139779 ENSMUST00000355338.1 ENSMUSG00000139779 (from geneSymbol) uc337ojq.1 uc337ojq.1 
ENSMUST00000355339.1 ENSMUSG00000139780 ENSMUST00000355339.1 ENSMUSG00000139780 (from geneSymbol) uc337ojr.1 uc337ojr.1 
ENSMUST00000355340.1 4930481B07Rik ENSMUST00000355340.1 4930481B07Rik (from geneSymbol) KY467940 uc337ojs.1 uc337ojs.1 
ENSMUST00000355341.1 ENSMUSG00000139781 ENSMUST00000355341.1 ENSMUSG00000139781 (from geneSymbol) uc337ojt.1 uc337ojt.1 
ENSMUST00000355342.1 Gm33619 ENSMUST00000355342.1 Gm33619 (from geneSymbol) AK041716 uc337oju.1 uc337oju.1 
ENSMUST00000355346.1 Gm38563 ENSMUST00000355346.1 Gm38563 (from geneSymbol) uc337ojy.1 uc337ojy.1 
ENSMUST00000355352.1 ENSMUSG00000139782 ENSMUST00000355352.1 ENSMUSG00000139782 (from geneSymbol) uc337oke.1 uc337oke.1 
ENSMUST00000355353.1 ENSMUSG00000139783 ENSMUST00000355353.1 ENSMUSG00000139783 (from geneSymbol) uc337okf.1 uc337okf.1 
ENSMUST00000355355.1 ENSMUSG00000139784 ENSMUST00000355355.1 ENSMUSG00000139784 (from geneSymbol) uc337okh.1 uc337okh.1 
ENSMUST00000355356.1 ENSMUSG00000139785 ENSMUST00000355356.1 ENSMUSG00000139785 (from geneSymbol) uc337oki.1 uc337oki.1 
ENSMUST00000355358.1 ENSMUSG00000139786 ENSMUST00000355358.1 ENSMUSG00000139786 (from geneSymbol) uc337okk.1 uc337okk.1 
ENSMUST00000355362.1 Gm49099 ENSMUST00000355362.1 Gm49099 (from geneSymbol) uc337oko.1 uc337oko.1 
ENSMUST00000355381.1 ENSMUSG00000139787 ENSMUST00000355381.1 ENSMUSG00000139787 (from geneSymbol) uc337olh.1 uc337olh.1 
ENSMUST00000355384.1 ENSMUSG00000139788 ENSMUST00000355384.1 ENSMUSG00000139788 (from geneSymbol) AK143382 uc337olk.1 uc337olk.1 
ENSMUST00000355385.1 ENSMUSG00000139789 ENSMUST00000355385.1 ENSMUSG00000139789 (from geneSymbol) AK020997 uc337oll.1 uc337oll.1 
ENSMUST00000355390.1 4933438K21Rik ENSMUST00000355390.1 4933438K21Rik (from geneSymbol) AK017111 uc337olq.1 uc337olq.1 
ENSMUST00000355405.1 BC006965 ENSMUST00000355405.1 BC006965 (from geneSymbol) AK048256 uc337omf.1 uc337omf.1 
ENSMUST00000355463.1 ENSMUSG00000139790 ENSMUST00000355463.1 ENSMUSG00000139790 (from geneSymbol) uc337ool.1 uc337ool.1 
ENSMUST00000355464.1 ENSMUSG00000139791 ENSMUST00000355464.1 ENSMUSG00000139791 (from geneSymbol) uc337oom.1 uc337oom.1 
ENSMUST00000355465.1 ENSMUSG00000139792 ENSMUST00000355465.1 ENSMUSG00000139792 (from geneSymbol) uc337oon.1 uc337oon.1 
ENSMUST00000355466.1 ENSMUSG00000139793 ENSMUST00000355466.1 ENSMUSG00000139793 (from geneSymbol) uc337ooo.1 uc337ooo.1 
ENSMUST00000355468.1 ENSMUSG00000139794 ENSMUST00000355468.1 ENSMUSG00000139794 (from geneSymbol) uc337ooq.1 uc337ooq.1 
ENSMUST00000355469.1 ENSMUSG00000139795 ENSMUST00000355469.1 ENSMUSG00000139795 (from geneSymbol) uc337oor.1 uc337oor.1 
ENSMUST00000355470.1 ENSMUSG00000139796 ENSMUST00000355470.1 ENSMUSG00000139796 (from geneSymbol) uc337oos.1 uc337oos.1 
ENSMUST00000355473.1 ENSMUSG00000139797 ENSMUST00000355473.1 ENSMUSG00000139797 (from geneSymbol) uc337oov.1 uc337oov.1 
ENSMUST00000355492.1 Gm53 ENSMUST00000355492.1 Gm53 (from geneSymbol) AK078566 uc337opo.1 uc337opo.1 
ENSMUST00000355522.1 Gm57055 ENSMUST00000355522.1 Gm57055 (from geneSymbol) uc337oqr.1 uc337oqr.1 
ENSMUST00000355527.1 ENSMUSG00000139798 ENSMUST00000355527.1 ENSMUSG00000139798 (from geneSymbol) uc337oqw.1 uc337oqw.1 
ENSMUST00000355528.1 ENSMUSG00000139799 ENSMUST00000355528.1 ENSMUSG00000139799 (from geneSymbol) uc337oqx.1 uc337oqx.1 
ENSMUST00000355529.1 ENSMUSG00000139800 ENSMUST00000355529.1 ENSMUSG00000139800 (from geneSymbol) uc337oqy.1 uc337oqy.1 
ENSMUST00000355532.1 ENSMUSG00000139801 ENSMUST00000355532.1 ENSMUSG00000139801 (from geneSymbol) uc337orb.1 uc337orb.1 
ENSMUST00000355533.1 ENSMUSG00000139802 ENSMUST00000355533.1 ENSMUSG00000139802 (from geneSymbol) uc337orc.1 uc337orc.1 
ENSMUST00000355534.1 ENSMUSG00000139803 ENSMUST00000355534.1 ENSMUSG00000139803 (from geneSymbol) uc337ord.1 uc337ord.1 
ENSMUST00000355539.1 ENSMUSG00000139804 ENSMUST00000355539.1 ENSMUSG00000139804 (from geneSymbol) uc337ori.1 uc337ori.1 
ENSMUST00000355540.1 Gm34611 ENSMUST00000355540.1 Gm34611 (from geneSymbol) uc337orj.1 uc337orj.1 
ENSMUST00000355546.1 ENSMUSG00000139805 ENSMUST00000355546.1 ENSMUSG00000139805 (from geneSymbol) uc337orp.1 uc337orp.1 
ENSMUST00000355548.1 ENSMUSG00000139806 ENSMUST00000355548.1 ENSMUSG00000139806 (from geneSymbol) uc337orr.1 uc337orr.1 
ENSMUST00000355550.1 ENSMUSG00000139807 ENSMUST00000355550.1 ENSMUSG00000139807 (from geneSymbol) uc337ort.1 uc337ort.1 
ENSMUST00000355555.1 AI839979 ENSMUST00000355555.1 AI839979 (from geneSymbol) AK036733 uc337ory.1 uc337ory.1 
ENSMUST00000355591.1 Gm34911 ENSMUST00000355591.1 Gm34911 (from geneSymbol) uc337oti.1 uc337oti.1 
ENSMUST00000355599.1 9130213A22Rik ENSMUST00000355599.1 9130213A22Rik (from geneSymbol) AK033665 uc337otq.1 uc337otq.1 
ENSMUST00000355601.1 ENSMUSG00000139808 ENSMUST00000355601.1 ENSMUSG00000139808 (from geneSymbol) uc337ots.1 uc337ots.1 
ENSMUST00000355632.1 ENSMUSG00000139809 ENSMUST00000355632.1 ENSMUSG00000139809 (from geneSymbol) X05260 uc337oux.1 uc337oux.1 
ENSMUST00000355633.1 ENSMUSG00000139810 ENSMUST00000355633.1 ENSMUSG00000139810 (from geneSymbol) uc337ouy.1 uc337ouy.1 
ENSMUST00000355634.1 ENSMUSG00000139811 ENSMUST00000355634.1 ENSMUSG00000139811 (from geneSymbol) uc337ouz.1 uc337ouz.1 
ENSMUST00000355635.1 ENSMUSG00000139812 ENSMUST00000355635.1 ENSMUSG00000139812 (from geneSymbol) uc337ova.1 uc337ova.1 
ENSMUST00000355636.1 ENSMUSG00000139813 ENSMUST00000355636.1 ENSMUSG00000139813 (from geneSymbol) uc337ovb.1 uc337ovb.1 
ENSMUST00000355637.1 ENSMUSG00000139814 ENSMUST00000355637.1 ENSMUSG00000139814 (from geneSymbol) uc337ovc.1 uc337ovc.1 
ENSMUST00000355644.1 ENSMUSG00000139815 ENSMUST00000355644.1 ENSMUSG00000139815 (from geneSymbol) uc337ovj.1 uc337ovj.1 
ENSMUST00000355650.1 ENSMUSG00000139816 ENSMUST00000355650.1 ENSMUSG00000139816 (from geneSymbol) uc337ovp.1 uc337ovp.1 
ENSMUST00000355652.1 ENSMUSG00000139817 ENSMUST00000355652.1 ENSMUSG00000139817 (from geneSymbol) uc337ovr.1 uc337ovr.1 
ENSMUST00000355653.1 ENSMUSG00000139818 ENSMUST00000355653.1 ENSMUSG00000139818 (from geneSymbol) uc337ovs.1 uc337ovs.1 
ENSMUST00000355661.1 ENSMUSG00000139819 ENSMUST00000355661.1 ENSMUSG00000139819 (from geneSymbol) uc337owa.1 uc337owa.1 
ENSMUST00000355663.1 ENSMUSG00000139820 ENSMUST00000355663.1 ENSMUSG00000139820 (from geneSymbol) uc337owc.1 uc337owc.1 
ENSMUST00000355668.1 ENSMUSG00000139821 ENSMUST00000355668.1 ENSMUSG00000139821 (from geneSymbol) uc337owh.1 uc337owh.1 
ENSMUST00000355669.1 ENSMUSG00000139822 ENSMUST00000355669.1 ENSMUSG00000139822 (from geneSymbol) uc337owi.1 uc337owi.1 
ENSMUST00000355673.1 Gm14662 ENSMUST00000355673.1 Gm14662 (from geneSymbol) AK135688 uc337owm.1 uc337owm.1 
ENSMUST00000355716.1 ENSMUSG00000139823 ENSMUST00000355716.1 ENSMUSG00000139823 (from geneSymbol) uc337oyd.1 uc337oyd.1 
ENSMUST00000355717.1 ENSMUSG00000139824 ENSMUST00000355717.1 ENSMUSG00000139824 (from geneSymbol) uc337oye.1 uc337oye.1 
ENSMUST00000355719.1 ENSMUSG00000139825 ENSMUST00000355719.1 ENSMUSG00000139825 (from geneSymbol) uc337oyg.1 uc337oyg.1 
ENSMUST00000355720.1 ENSMUSG00000139826 ENSMUST00000355720.1 ENSMUSG00000139826 (from geneSymbol) AK016790 uc337oyh.1 uc337oyh.1 
ENSMUST00000355721.1 Gm3287 ENSMUST00000355721.1 Gm3287 (from geneSymbol) AK143833 uc337oyi.1 uc337oyi.1 
ENSMUST00000355762.1 ENSMUSG00000139827 ENSMUST00000355762.1 ENSMUSG00000139827 (from geneSymbol) uc337ozv.1 uc337ozv.1 
ENSMUST00000355763.1 ENSMUSG00000139828 ENSMUST00000355763.1 ENSMUSG00000139828 (from geneSymbol) uc337ozw.1 uc337ozw.1 
ENSMUST00000355765.1 Gm57075 ENSMUST00000355765.1 Gm57075 (from geneSymbol) uc337ozy.1 uc337ozy.1 
ENSMUST00000355766.1 ENSMUSG00000139829 ENSMUST00000355766.1 ENSMUSG00000139829 (from geneSymbol) uc337ozz.1 uc337ozz.1 
ENSMUST00000355767.1 Gm12280 ENSMUST00000355767.1 Gm12280 (from geneSymbol) AK037448 uc337paa.1 uc337paa.1 
ENSMUST00000355768.1 ENSMUSG00000139830 ENSMUST00000355768.1 ENSMUSG00000139830 (from geneSymbol) uc337pab.1 uc337pab.1 
ENSMUST00000355769.1 Gm11681 ENSMUST00000355769.1 Gm11681 (from geneSymbol) AK138212 uc337pac.1 uc337pac.1 
ENSMUST00000355784.1 ENSMUSG00000139831 ENSMUST00000355784.1 ENSMUSG00000139831 (from geneSymbol) uc337par.1 uc337par.1 
ENSMUST00000355786.1 ENSMUSG00000139832 ENSMUST00000355786.1 ENSMUSG00000139832 (from geneSymbol) uc337pat.1 uc337pat.1 
ENSMUST00000355787.1 ENSMUSG00000139833 ENSMUST00000355787.1 ENSMUSG00000139833 (from geneSymbol) uc337pau.1 uc337pau.1 
ENSMUST00000355788.1 ENSMUSG00000139834 ENSMUST00000355788.1 ENSMUSG00000139834 (from geneSymbol) AK033592 uc337pav.1 uc337pav.1 
ENSMUST00000355789.1 ENSMUSG00000139835 ENSMUST00000355789.1 ENSMUSG00000139835 (from geneSymbol) uc337paw.1 uc337paw.1 
ENSMUST00000355790.1 ENSMUSG00000139836 ENSMUST00000355790.1 ENSMUSG00000139836 (from geneSymbol) uc337pax.1 uc337pax.1 
ENSMUST00000355791.1 2610306M01Rik ENSMUST00000355791.1 2610306M01Rik (from geneSymbol) uc337pay.1 uc337pay.1 
ENSMUST00000355796.1 ENSMUSG00000139838 ENSMUST00000355796.1 ENSMUSG00000139838 (from geneSymbol) uc337pbc.1 uc337pbc.1 
ENSMUST00000355806.1 4930502E09Rik ENSMUST00000355806.1 4930502E09Rik (from geneSymbol) AK015677 uc337pbd.1 uc337pbd.1 
ENSMUST00000355814.1 ENSMUSG00000139840 ENSMUST00000355814.1 ENSMUSG00000139840 (from geneSymbol) uc337pbl.1 uc337pbl.1 
ENSMUST00000355816.1 Gm15775 ENSMUST00000355816.1 Gm15775 (from geneSymbol) AK085459 uc337pbn.1 uc337pbn.1 
ENSMUST00000355820.1 ENSMUSG00000139841 ENSMUST00000355820.1 ENSMUSG00000139841 (from geneSymbol) uc337pbr.1 uc337pbr.1 
ENSMUST00000355822.1 ENSMUSG00000139842 ENSMUST00000355822.1 ENSMUSG00000139842 (from geneSymbol) uc337pbt.1 uc337pbt.1 
ENSMUST00000355824.1 ENSMUSG00000139843 ENSMUST00000355824.1 ENSMUSG00000139843 (from geneSymbol) uc337pbv.1 uc337pbv.1 
ENSMUST00000355825.1 ENSMUSG00000139844 ENSMUST00000355825.1 ENSMUSG00000139844 (from geneSymbol) uc337pbw.1 uc337pbw.1 
ENSMUST00000355831.1 ENSMUSG00000139845 ENSMUST00000355831.1 ENSMUSG00000139845 (from geneSymbol) uc337pcc.1 uc337pcc.1 
ENSMUST00000355833.1 ENSMUSG00000139846 ENSMUST00000355833.1 ENSMUSG00000139846 (from geneSymbol) uc337pce.1 uc337pce.1 
ENSMUST00000355834.1 ENSMUSG00000139847 ENSMUST00000355834.1 ENSMUSG00000139847 (from geneSymbol) uc337pcf.1 uc337pcf.1 
ENSMUST00000355835.1 ENSMUSG00000139848 ENSMUST00000355835.1 ENSMUSG00000139848 (from geneSymbol) uc337pcg.1 uc337pcg.1 
ENSMUST00000355837.1 ENSMUSG00000139849 ENSMUST00000355837.1 ENSMUSG00000139849 (from geneSymbol) uc337pci.1 uc337pci.1 
ENSMUST00000355838.1 ENSMUSG00000139850 ENSMUST00000355838.1 ENSMUSG00000139850 (from geneSymbol) uc337pcj.1 uc337pcj.1 
ENSMUST00000355839.1 ENSMUSG00000139851 ENSMUST00000355839.1 ENSMUSG00000139851 (from geneSymbol) uc337pck.1 uc337pck.1 
ENSMUST00000355843.1 ENSMUSG00000139852 ENSMUST00000355843.1 ENSMUSG00000139852 (from geneSymbol) uc337pco.1 uc337pco.1 
ENSMUST00000355844.1 ENSMUSG00000139853 ENSMUST00000355844.1 ENSMUSG00000139853 (from geneSymbol) uc337pcp.1 uc337pcp.1 
ENSMUST00000355845.1 ENSMUSG00000139854 ENSMUST00000355845.1 ENSMUSG00000139854 (from geneSymbol) uc337pcq.1 uc337pcq.1 
ENSMUST00000355849.1 Gm52907 ENSMUST00000355849.1 predicted gene, 52907, transcript variant 2 (from RefSeq NR_168046.1) NR_168046 uc337pcu.1 uc337pcu.1 
ENSMUST00000355850.1 ENSMUSG00000139856 ENSMUST00000355850.1 ENSMUSG00000139856 (from geneSymbol) uc337pcv.1 uc337pcv.1 
ENSMUST00000355851.1 ENSMUSG00000139857 ENSMUST00000355851.1 ENSMUSG00000139857 (from geneSymbol) uc337pcw.1 uc337pcw.1 
ENSMUST00000355852.1 B230209E15Rik ENSMUST00000355852.1 B230209E15Rik (from geneSymbol) AK045535 uc337pcx.1 uc337pcx.1 
ENSMUST00000355900.1 ENSMUSG00000139858 ENSMUST00000355900.1 ENSMUSG00000139858 (from geneSymbol) uc337per.1 uc337per.1 
ENSMUST00000355901.1 ENSMUSG00000139859 ENSMUST00000355901.1 ENSMUSG00000139859 (from geneSymbol) uc337pes.1 uc337pes.1 
ENSMUST00000355903.1 ENSMUSG00000139860 ENSMUST00000355903.1 ENSMUSG00000139860 (from geneSymbol) uc337peu.1 uc337peu.1 
ENSMUST00000355905.1 ENSMUSG00000139861 ENSMUST00000355905.1 ENSMUSG00000139861 (from geneSymbol) uc337pew.1 uc337pew.1 
ENSMUST00000355908.1 ENSMUSG00000139862 ENSMUST00000355908.1 ENSMUSG00000139862 (from geneSymbol) uc337pez.1 uc337pez.1 
ENSMUST00000355910.1 ENSMUSG00000139863 ENSMUST00000355910.1 ENSMUSG00000139863 (from geneSymbol) uc337pfb.1 uc337pfb.1 
ENSMUST00000355914.1 Tekt5l ENSMUST00000355914.1 tektin 5 like (from RefSeq NR_174984.1) NR_174984 uc337pff.1 uc337pff.1 
ENSMUST00000355915.1 ENSMUSG00000139865 ENSMUST00000355915.1 ENSMUSG00000139865 (from geneSymbol) uc337pfg.1 uc337pfg.1 
ENSMUST00000355917.1 ENSMUSG00000139866 ENSMUST00000355917.1 ENSMUSG00000139866 (from geneSymbol) uc337pfi.1 uc337pfi.1 
ENSMUST00000355918.1 ENSMUSG00000139867 ENSMUST00000355918.1 ENSMUSG00000139867 (from geneSymbol) uc337pfj.1 uc337pfj.1 
ENSMUST00000355925.1 ENSMUSG00000139868 ENSMUST00000355925.1 ENSMUSG00000139868 (from geneSymbol) uc337pfq.1 uc337pfq.1 
ENSMUST00000355941.1 Gm6297 ENSMUST00000355941.1 Gm6297 (from geneSymbol) AK139295 uc337pgg.1 uc337pgg.1 
ENSMUST00000355950.1 Rbm46os ENSMUST00000355950.1 Rbm46os (from geneSymbol) AK019784 uc337pgp.1 uc337pgp.1 
ENSMUST00000355975.1 ENSMUSG00000139869 ENSMUST00000355975.1 ENSMUSG00000139869 (from geneSymbol) uc337pho.1 uc337pho.1 
ENSMUST00000355980.1 ENSMUSG00000139870 ENSMUST00000355980.1 ENSMUSG00000139870 (from geneSymbol) uc337pht.1 uc337pht.1 
ENSMUST00000355981.1 ENSMUSG00000139871 ENSMUST00000355981.1 ENSMUSG00000139871 (from geneSymbol) uc337phu.1 uc337phu.1 
ENSMUST00000355982.1 ENSMUSG00000139872 ENSMUST00000355982.1 ENSMUSG00000139872 (from geneSymbol) uc337phv.1 uc337phv.1 
ENSMUST00000355983.1 ENSMUSG00000139873 ENSMUST00000355983.1 ENSMUSG00000139873 (from geneSymbol) uc337phw.1 uc337phw.1 
ENSMUST00000355985.1 ENSMUSG00000139874 ENSMUST00000355985.1 ENSMUSG00000139874 (from geneSymbol) uc337phy.1 uc337phy.1 
ENSMUST00000355988.1 ENSMUSG00000139875 ENSMUST00000355988.1 ENSMUSG00000139875 (from geneSymbol) uc337pib.1 uc337pib.1 
ENSMUST00000355991.1 Platr14 ENSMUST00000355991.1 Platr14 (from geneSymbol) AK015665 uc337pie.1 uc337pie.1 
ENSMUST00000356015.1 ENSMUSG00000139876 ENSMUST00000356015.1 ENSMUSG00000139876 (from geneSymbol) uc337pjc.1 uc337pjc.1 
ENSMUST00000356017.1 ENSMUSG00000139877 ENSMUST00000356017.1 ENSMUSG00000139877 (from geneSymbol) uc337pje.1 uc337pje.1 
ENSMUST00000356024.1 ENSMUSG00000139879 ENSMUST00000356024.1 ENSMUSG00000139879 (from geneSymbol) uc337pjj.1 uc337pjj.1 
ENSMUST00000356045.1 ENSMUSG00000139880 ENSMUST00000356045.1 ENSMUSG00000139880 (from geneSymbol) uc337pkd.1 uc337pkd.1 
ENSMUST00000356046.1 ENSMUSG00000139881 ENSMUST00000356046.1 ENSMUSG00000139881 (from geneSymbol) uc337pke.1 uc337pke.1 
ENSMUST00000356051.1 Gm47465 ENSMUST00000356051.1 Gm47465 (from geneSymbol) uc337pkj.1 uc337pkj.1 
ENSMUST00000356094.1 Gm57352 ENSMUST00000356094.1 Gm57352 (from geneSymbol) KF703535 uc337pma.1 uc337pma.1 
ENSMUST00000356136.1 ENSMUSG00000139882 ENSMUST00000356136.1 ENSMUSG00000139882 (from geneSymbol) uc337pnq.1 uc337pnq.1 
ENSMUST00000356139.1 ENSMUSG00000139883 ENSMUST00000356139.1 ENSMUSG00000139883 (from geneSymbol) uc337pnt.1 uc337pnt.1 
ENSMUST00000356140.1 ENSMUSG00000139884 ENSMUST00000356140.1 ENSMUSG00000139884 (from geneSymbol) uc337pnu.1 uc337pnu.1 
ENSMUST00000356142.1 ENSMUSG00000139885 ENSMUST00000356142.1 ENSMUSG00000139885 (from geneSymbol) uc337pnw.1 uc337pnw.1 
ENSMUST00000356145.1 ENSMUSG00000139886 ENSMUST00000356145.1 ENSMUSG00000139886 (from geneSymbol) uc337pnz.1 uc337pnz.1 
ENSMUST00000356152.1 ENSMUSG00000139887 ENSMUST00000356152.1 ENSMUSG00000139887 (from geneSymbol) AK015236 uc337pog.1 uc337pog.1 
ENSMUST00000356176.1 ENSMUSG00000139888 ENSMUST00000356176.1 ENSMUSG00000139888 (from geneSymbol) uc337ppe.1 uc337ppe.1 
ENSMUST00000356178.1 ENSMUSG00000139889 ENSMUST00000356178.1 ENSMUSG00000139889 (from geneSymbol) uc337ppg.1 uc337ppg.1 
ENSMUST00000356180.1 ENSMUSG00000139890 ENSMUST00000356180.1 ENSMUSG00000139890 (from geneSymbol) uc337ppi.1 uc337ppi.1 
ENSMUST00000356185.1 ENSMUSG00000139891 ENSMUST00000356185.1 ENSMUSG00000139891 (from geneSymbol) FJ654118 uc337ppn.1 uc337ppn.1 
ENSMUST00000356191.1 ENSMUSG00000139892 ENSMUST00000356191.1 ENSMUSG00000139892 (from geneSymbol) uc337ppt.1 uc337ppt.1 
ENSMUST00000356192.1 ENSMUSG00000139893 ENSMUST00000356192.1 ENSMUSG00000139893 (from geneSymbol) uc337ppu.1 uc337ppu.1 
ENSMUST00000356195.1 ENSMUSG00000139894 ENSMUST00000356195.1 ENSMUSG00000139894 (from geneSymbol) uc337ppx.1 uc337ppx.1 
ENSMUST00000356197.1 ENSMUSG00000139895 ENSMUST00000356197.1 ENSMUSG00000139895 (from geneSymbol) uc337ppz.1 uc337ppz.1 
ENSMUST00000356198.1 ENSMUSG00000139896 ENSMUST00000356198.1 ENSMUSG00000139896 (from geneSymbol) uc337pqa.1 uc337pqa.1 
ENSMUST00000356200.1 ENSMUSG00000139897 ENSMUST00000356200.1 ENSMUSG00000139897 (from geneSymbol) uc337pqc.1 uc337pqc.1 
ENSMUST00000356206.1 ENSMUSG00000139898 ENSMUST00000356206.1 ENSMUSG00000139898 (from geneSymbol) uc337pqi.1 uc337pqi.1 
ENSMUST00000356207.1 ENSMUSG00000139899 ENSMUST00000356207.1 ENSMUSG00000139899 (from geneSymbol) uc337pqj.1 uc337pqj.1 
ENSMUST00000356208.1 ENSMUSG00000139900 ENSMUST00000356208.1 ENSMUSG00000139900 (from geneSymbol) uc337pqk.1 uc337pqk.1 
ENSMUST00000356210.1 Gm41225 ENSMUST00000356210.1 Gm41225 (from geneSymbol) uc337pqm.1 uc337pqm.1 
ENSMUST00000356222.1 ENSMUSG00000139901 ENSMUST00000356222.1 ENSMUSG00000139901 (from geneSymbol) uc337pqy.1 uc337pqy.1 
ENSMUST00000356224.1 ENSMUSG00000139902 ENSMUST00000356224.1 ENSMUSG00000139902 (from geneSymbol) uc337pra.1 uc337pra.1 
ENSMUST00000356228.1 ENSMUSG00000139903 ENSMUST00000356228.1 ENSMUSG00000139903 (from geneSymbol) uc337pre.1 uc337pre.1 
ENSMUST00000356230.1 ENSMUSG00000139904 ENSMUST00000356230.1 ENSMUSG00000139904 (from geneSymbol) uc337prg.1 uc337prg.1 
ENSMUST00000356231.1 Gm56506 ENSMUST00000356231.1 Gm56506 (from geneSymbol) uc337prh.1 uc337prh.1 
ENSMUST00000356236.1 ENSMUSG00000139905 ENSMUST00000356236.1 ENSMUSG00000139905 (from geneSymbol) uc337prm.1 uc337prm.1 
ENSMUST00000356240.1 ENSMUSG00000139906 ENSMUST00000356240.1 ENSMUSG00000139906 (from geneSymbol) uc337prq.1 uc337prq.1 
ENSMUST00000356242.1 ENSMUSG00000139907 ENSMUST00000356242.1 ENSMUSG00000139907 (from geneSymbol) AK019745 uc337prs.1 uc337prs.1 
ENSMUST00000356244.1 ENSMUSG00000139908 ENSMUST00000356244.1 ENSMUSG00000139908 (from geneSymbol) uc337pru.1 uc337pru.1 
ENSMUST00000356247.1 ENSMUSG00000139909 ENSMUST00000356247.1 ENSMUSG00000139909 (from geneSymbol) uc337prx.1 uc337prx.1 
ENSMUST00000356248.1 ENSMUSG00000139910 ENSMUST00000356248.1 ENSMUSG00000139910 (from geneSymbol) uc337pry.1 uc337pry.1 
ENSMUST00000356254.1 ENSMUSG00000139911 ENSMUST00000356254.1 ENSMUSG00000139911 (from geneSymbol) uc337pse.1 uc337pse.1 
ENSMUST00000356261.1 Gm30097 ENSMUST00000356261.1 Gm30097 (from geneSymbol) uc337psl.1 uc337psl.1 
ENSMUST00000356264.1 ENSMUSG00000139912 ENSMUST00000356264.1 ENSMUSG00000139912 (from geneSymbol) LF233117 uc337pso.1 uc337pso.1 
ENSMUST00000356265.1 ENSMUSG00000139913 ENSMUST00000356265.1 ENSMUSG00000139913 (from geneSymbol) uc337psp.1 uc337psp.1 
ENSMUST00000356289.1 ENSMUSG00000139914 ENSMUST00000356289.1 ENSMUSG00000139914 (from geneSymbol) uc337ptn.1 uc337ptn.1 
ENSMUST00000356292.1 1700095J07Rik ENSMUST00000356292.1 1700095J07Rik (from geneSymbol) AK132961 uc337ptp.1 uc337ptp.1 
ENSMUST00000356303.1 ENSMUSG00000139916 ENSMUST00000356303.1 ENSMUSG00000139916 (from geneSymbol) uc337pua.1 uc337pua.1 
ENSMUST00000356305.1 ENSMUSG00000139917 ENSMUST00000356305.1 ENSMUSG00000139917 (from geneSymbol) uc337puc.1 uc337puc.1 
ENSMUST00000356309.1 ENSMUSG00000139918 ENSMUST00000356309.1 ENSMUSG00000139918 (from geneSymbol) uc337pug.1 uc337pug.1 
ENSMUST00000356312.1 Gm34833 ENSMUST00000356312.1 Gm34833 (from geneSymbol) uc337puj.1 uc337puj.1 
ENSMUST00000356317.1 ENSMUSG00000139919 ENSMUST00000356317.1 ENSMUSG00000139919 (from geneSymbol) uc337puo.1 uc337puo.1 
ENSMUST00000356318.1 ENSMUSG00000139920 ENSMUST00000356318.1 ENSMUSG00000139920 (from geneSymbol) BC058988 uc337pup.1 uc337pup.1 
ENSMUST00000356327.1 ENSMUSG00000139923 ENSMUST00000356327.1 ENSMUSG00000139923 (from geneSymbol) uc337puw.1 uc337puw.1 
ENSMUST00000356328.1 ENSMUSG00000139924 ENSMUST00000356328.1 ENSMUSG00000139924 (from geneSymbol) uc337pux.1 uc337pux.1 
ENSMUST00000356334.1 ENSMUSG00000139926 ENSMUST00000356334.1 ENSMUSG00000139926 (from geneSymbol) uc337pvc.1 uc337pvc.1 
ENSMUST00000356335.1 ENSMUSG00000139927 ENSMUST00000356335.1 ENSMUSG00000139927 (from geneSymbol) uc337pvd.1 uc337pvd.1 
ENSMUST00000356336.1 ENSMUSG00000139928 ENSMUST00000356336.1 ENSMUSG00000139928 (from geneSymbol) uc337pve.1 uc337pve.1 
ENSMUST00000356341.1 G630016G05Rik ENSMUST00000356341.1 G630016G05Rik (from geneSymbol) AK144314 uc337pvj.1 uc337pvj.1 
ENSMUST00000356413.1 ENSMUSG00000139929 ENSMUST00000356413.1 ENSMUSG00000139929 (from geneSymbol) uc337pyd.1 uc337pyd.1 
ENSMUST00000356415.1 1700006H21Rik ENSMUST00000356415.1 1700006H21Rik (from geneSymbol) AK005677 uc337pyf.1 uc337pyf.1 
ENSMUST00000356430.1 ENSMUSG00000139930 ENSMUST00000356430.1 ENSMUSG00000139930 (from geneSymbol) uc337pyu.1 uc337pyu.1 
ENSMUST00000356433.1 ENSMUSG00000139931 ENSMUST00000356433.1 ENSMUSG00000139931 (from geneSymbol) uc337pyx.1 uc337pyx.1 
ENSMUST00000356434.1 ENSMUSG00000139932 ENSMUST00000356434.1 ENSMUSG00000139932 (from geneSymbol) uc337pyy.1 uc337pyy.1 
ENSMUST00000356437.1 ENSMUSG00000139933 ENSMUST00000356437.1 ENSMUSG00000139933 (from geneSymbol) AK007159 uc337pzb.1 uc337pzb.1 
ENSMUST00000356444.1 ENSMUSG00000139934 ENSMUST00000356444.1 ENSMUSG00000139934 (from geneSymbol) uc337pzi.1 uc337pzi.1 
ENSMUST00000356445.1 ENSMUSG00000139935 ENSMUST00000356445.1 ENSMUSG00000139935 (from geneSymbol) uc337pzj.1 uc337pzj.1 
ENSMUST00000356448.1 ENSMUSG00000139936 ENSMUST00000356448.1 ENSMUSG00000139936 (from geneSymbol) uc337pzm.1 uc337pzm.1 
ENSMUST00000356465.1 ENSMUSG00000139937 ENSMUST00000356465.1 ENSMUSG00000139937 (from geneSymbol) uc337qad.1 uc337qad.1 
ENSMUST00000356466.1 ENSMUSG00000139938 ENSMUST00000356466.1 ENSMUSG00000139938 (from geneSymbol) uc337qae.1 uc337qae.1 
ENSMUST00000356467.1 ENSMUSG00000139939 ENSMUST00000356467.1 ENSMUSG00000139939 (from geneSymbol) AK029823 uc337qaf.1 uc337qaf.1 
ENSMUST00000356493.1 Gm35298 ENSMUST00000356493.1 Gm35298 (from geneSymbol) uc337qbc.1 uc337qbc.1 
ENSMUST00000356505.1 ENSMUSG00000139940 ENSMUST00000356505.1 ENSMUSG00000139940 (from geneSymbol) uc337qbo.1 uc337qbo.1 
ENSMUST00000356506.1 ENSMUSG00000139941 ENSMUST00000356506.1 ENSMUSG00000139941 (from geneSymbol) uc337qbp.1 uc337qbp.1 
ENSMUST00000356507.1 Gm45037 ENSMUST00000356507.1 Gm45037 (from geneSymbol) uc337qbq.1 uc337qbq.1 
ENSMUST00000356513.1 ENSMUSG00000139942 ENSMUST00000356513.1 ENSMUSG00000139942 (from geneSymbol) uc337qbw.1 uc337qbw.1 
ENSMUST00000356515.1 Gm56708 ENSMUST00000356515.1 Gm56708 (from geneSymbol) uc337qby.1 uc337qby.1 
ENSMUST00000356522.1 ENSMUSG00000139944 ENSMUST00000356522.1 ENSMUSG00000139944 (from geneSymbol) uc337qcf.1 uc337qcf.1 
ENSMUST00000356523.1 ENSMUSG00000139945 ENSMUST00000356523.1 ENSMUSG00000139945 (from geneSymbol) uc337qcg.1 uc337qcg.1 
ENSMUST00000356527.1 ENSMUSG00000139946 ENSMUST00000356527.1 ENSMUSG00000139946 (from geneSymbol) uc337qck.1 uc337qck.1 
ENSMUST00000356528.1 ENSMUSG00000139947 ENSMUST00000356528.1 ENSMUSG00000139947 (from geneSymbol) uc337qcl.1 uc337qcl.1 
ENSMUST00000356530.1 ENSMUSG00000139948 ENSMUST00000356530.1 ENSMUSG00000139948 (from geneSymbol) uc337qcn.1 uc337qcn.1 
ENSMUST00000356534.1 ENSMUSG00000139949 ENSMUST00000356534.1 ENSMUSG00000139949 (from geneSymbol) uc337qcr.1 uc337qcr.1 
ENSMUST00000356535.1 ENSMUSG00000139950 ENSMUST00000356535.1 ENSMUSG00000139950 (from geneSymbol) uc337qcs.1 uc337qcs.1 
ENSMUST00000356536.1 ENSMUSG00000139951 ENSMUST00000356536.1 ENSMUSG00000139951 (from geneSymbol) uc337qct.1 uc337qct.1 
ENSMUST00000356537.1 ENSMUSG00000139952 ENSMUST00000356537.1 ENSMUSG00000139952 (from geneSymbol) uc337qcu.1 uc337qcu.1 
ENSMUST00000356540.1 ENSMUSG00000139953 ENSMUST00000356540.1 ENSMUSG00000139953 (from geneSymbol) uc337qcx.1 uc337qcx.1 
ENSMUST00000356545.1 ENSMUSG00000139954 ENSMUST00000356545.1 ENSMUSG00000139954 (from geneSymbol) uc337qdc.1 uc337qdc.1 
ENSMUST00000356546.1 Gm57350 ENSMUST00000356546.1 Gm57350 (from geneSymbol) uc337qdd.1 uc337qdd.1 
ENSMUST00000356548.1 ENSMUSG00000139955 ENSMUST00000356548.1 ENSMUSG00000139955 (from geneSymbol) uc337qdf.1 uc337qdf.1 
ENSMUST00000356549.1 ENSMUSG00000139956 ENSMUST00000356549.1 ENSMUSG00000139956 (from geneSymbol) uc337qdg.1 uc337qdg.1 
ENSMUST00000356550.1 ENSMUSG00000139957 ENSMUST00000356550.1 ENSMUSG00000139957 (from geneSymbol) uc337qdh.1 uc337qdh.1 
ENSMUST00000356566.1 ENSMUSG00000139958 ENSMUST00000356566.1 ENSMUSG00000139958 (from geneSymbol) uc337qdx.1 uc337qdx.1 
ENSMUST00000356570.1 ENSMUSG00000139959 ENSMUST00000356570.1 ENSMUSG00000139959 (from geneSymbol) uc337qeb.1 uc337qeb.1 
ENSMUST00000356573.1 ENSMUSG00000139960 ENSMUST00000356573.1 ENSMUSG00000139960 (from geneSymbol) uc337qee.1 uc337qee.1 
ENSMUST00000356590.1 Gm13031 ENSMUST00000356590.1 Gm13031 (from geneSymbol) AK040418 uc337qev.1 uc337qev.1 
ENSMUST00000356599.1 ENSMUSG00000139961 ENSMUST00000356599.1 ENSMUSG00000139961 (from geneSymbol) uc337qfe.1 uc337qfe.1 
ENSMUST00000356600.1 ENSMUSG00000139962 ENSMUST00000356600.1 ENSMUSG00000139962 (from geneSymbol) uc337qff.1 uc337qff.1 
ENSMUST00000356601.1 ENSMUSG00000139963 ENSMUST00000356601.1 ENSMUSG00000139963 (from geneSymbol) uc337qfg.1 uc337qfg.1 
ENSMUST00000356602.1 ENSMUSG00000139964 ENSMUST00000356602.1 ENSMUSG00000139964 (from geneSymbol) uc337qfh.1 uc337qfh.1 
ENSMUST00000356606.1 Gm31126 ENSMUST00000356606.1 Gm31126 (from geneSymbol) AK030049 uc337qfl.1 uc337qfl.1 
ENSMUST00000356652.1 ENSMUSG00000139965 ENSMUST00000356652.1 ENSMUSG00000139965 (from geneSymbol) uc337qhf.1 uc337qhf.1 
ENSMUST00000356656.1 ENSMUSG00000139966 ENSMUST00000356656.1 ENSMUSG00000139966 (from geneSymbol) uc337qhj.1 uc337qhj.1 
ENSMUST00000356657.1 ENSMUSG00000139967 ENSMUST00000356657.1 ENSMUSG00000139967 (from geneSymbol) uc337qhk.1 uc337qhk.1 
ENSMUST00000356658.1 ENSMUSG00000139968 ENSMUST00000356658.1 ENSMUSG00000139968 (from geneSymbol) uc337qhl.1 uc337qhl.1 
ENSMUST00000356673.1 ENSMUSG00000139969 ENSMUST00000356673.1 ENSMUSG00000139969 (from geneSymbol) uc337qia.1 uc337qia.1 
ENSMUST00000356674.1 ENSMUSG00000139970 ENSMUST00000356674.1 ENSMUSG00000139970 (from geneSymbol) uc337qib.1 uc337qib.1 
ENSMUST00000356678.1 ENSMUSG00000139971 ENSMUST00000356678.1 ENSMUSG00000139971 (from geneSymbol) uc337qif.1 uc337qif.1 
ENSMUST00000356679.1 Gm46409 ENSMUST00000356679.1 Gm46409 (from geneSymbol) uc337qig.1 uc337qig.1 
ENSMUST00000356680.1 ENSMUSG00000139972 ENSMUST00000356680.1 ENSMUSG00000139972 (from geneSymbol) uc337qih.1 uc337qih.1 
ENSMUST00000356681.1 ENSMUSG00000139973 ENSMUST00000356681.1 ENSMUSG00000139973 (from geneSymbol) uc337qii.1 uc337qii.1 
ENSMUST00000356682.1 ENSMUSG00000139974 ENSMUST00000356682.1 ENSMUSG00000139974 (from geneSymbol) AK006266 uc337qij.1 uc337qij.1 
ENSMUST00000356683.1 ENSMUSG00000139975 ENSMUST00000356683.1 ENSMUSG00000139975 (from geneSymbol) uc337qik.1 uc337qik.1 
ENSMUST00000356686.1 ENSMUSG00000139976 ENSMUST00000356686.1 ENSMUSG00000139976 (from geneSymbol) uc337qin.1 uc337qin.1 
ENSMUST00000356699.1 ENSMUSG00000139977 ENSMUST00000356699.1 ENSMUSG00000139977 (from geneSymbol) uc337qja.1 uc337qja.1 
ENSMUST00000356708.1 ENSMUSG00000139979 ENSMUST00000356708.1 ENSMUSG00000139979 (from geneSymbol) uc337qjh.1 uc337qjh.1 
ENSMUST00000356709.1 ENSMUSG00000139980 ENSMUST00000356709.1 ENSMUSG00000139980 (from geneSymbol) uc337qji.1 uc337qji.1 
ENSMUST00000356724.1 ENSMUSG00000139981 ENSMUST00000356724.1 ENSMUSG00000139981 (from geneSymbol) uc337qjx.1 uc337qjx.1 
ENSMUST00000356725.1 ENSMUSG00000139982 ENSMUST00000356725.1 ENSMUSG00000139982 (from geneSymbol) uc337qjy.1 uc337qjy.1 
ENSMUST00000356731.1 ENSMUSG00000139983 ENSMUST00000356731.1 ENSMUSG00000139983 (from geneSymbol) uc337qke.1 uc337qke.1 
ENSMUST00000356732.1 Gm56723 ENSMUST00000356732.1 Gm56723 (from geneSymbol) uc337qkf.1 uc337qkf.1 
ENSMUST00000356737.1 ENSMUSG00000139984 ENSMUST00000356737.1 ENSMUSG00000139984 (from geneSymbol) uc337qkk.1 uc337qkk.1 
ENSMUST00000356738.1 ENSMUSG00000139985 ENSMUST00000356738.1 ENSMUSG00000139985 (from geneSymbol) uc337qkl.1 uc337qkl.1 
ENSMUST00000356743.1 ENSMUSG00000139986 ENSMUST00000356743.1 ENSMUSG00000139986 (from geneSymbol) uc337qkq.1 uc337qkq.1 
ENSMUST00000356745.1 ENSMUSG00000139987 ENSMUST00000356745.1 ENSMUSG00000139987 (from geneSymbol) uc337qks.1 uc337qks.1 
ENSMUST00000356747.1 ENSMUSG00000139988 ENSMUST00000356747.1 ENSMUSG00000139988 (from geneSymbol) uc337qku.1 uc337qku.1 
ENSMUST00000356752.1 ENSMUSG00000139989 ENSMUST00000356752.1 ENSMUSG00000139989 (from geneSymbol) uc337qkz.1 uc337qkz.1 
ENSMUST00000356759.1 ENSMUSG00000139990 ENSMUST00000356759.1 ENSMUSG00000139990 (from geneSymbol) uc337qlg.1 uc337qlg.1 
ENSMUST00000356789.1 ENSMUSG00000139991 ENSMUST00000356789.1 ENSMUSG00000139991 (from geneSymbol) uc337qmk.1 uc337qmk.1 
ENSMUST00000356790.1 ENSMUSG00000139992 ENSMUST00000356790.1 ENSMUSG00000139992 (from geneSymbol) uc337qml.1 uc337qml.1 
ENSMUST00000356791.1 ENSMUSG00000139993 ENSMUST00000356791.1 ENSMUSG00000139993 (from geneSymbol) uc337qmm.1 uc337qmm.1 
ENSMUST00000356798.1 ENSMUSG00000139994 ENSMUST00000356798.1 ENSMUSG00000139994 (from geneSymbol) uc337qmt.1 uc337qmt.1 
ENSMUST00000356799.1 ENSMUSG00000139995 ENSMUST00000356799.1 ENSMUSG00000139995 (from geneSymbol) uc337qmu.1 uc337qmu.1 
ENSMUST00000356801.1 ENSMUSG00000139996 ENSMUST00000356801.1 ENSMUSG00000139996 (from geneSymbol) uc337qmw.1 uc337qmw.1 
ENSMUST00000356804.1 Gm41231 ENSMUST00000356804.1 Gm41231 (from geneSymbol) KY467713 uc337qmz.1 uc337qmz.1 
ENSMUST00000356826.1 ENSMUSG00000139997 ENSMUST00000356826.1 ENSMUSG00000139997 (from geneSymbol) uc337qnv.1 uc337qnv.1 
ENSMUST00000356828.1 Gm15523 ENSMUST00000356828.1 Gm15523 (from geneSymbol) KY467651 uc337qnx.1 uc337qnx.1 
ENSMUST00000356839.1 ENSMUSG00000139998 ENSMUST00000356839.1 ENSMUSG00000139998 (from geneSymbol) uc337qoi.1 uc337qoi.1 
ENSMUST00000356840.1 ENSMUSG00000139999 ENSMUST00000356840.1 ENSMUSG00000139999 (from geneSymbol) uc337qoj.1 uc337qoj.1 
ENSMUST00000356842.1 ENSMUSG00000140000 ENSMUST00000356842.1 ENSMUSG00000140000 (from geneSymbol) uc337qol.1 uc337qol.1 
ENSMUST00000356843.1 ENSMUSG00000140001 ENSMUST00000356843.1 ENSMUSG00000140001 (from geneSymbol) uc337qom.1 uc337qom.1 
ENSMUST00000356847.1 ENSMUSG00000140002 ENSMUST00000356847.1 ENSMUSG00000140002 (from geneSymbol) uc337qoq.1 uc337qoq.1 
ENSMUST00000356855.1 ENSMUSG00000140003 ENSMUST00000356855.1 ENSMUSG00000140003 (from geneSymbol) uc337qoy.1 uc337qoy.1 
ENSMUST00000356953.1 ENSMUSG00000140004 ENSMUST00000356953.1 ENSMUSG00000140004 (from geneSymbol) uc337qss.1 uc337qss.1 
ENSMUST00000357008.1 ENSMUSG00000140005 ENSMUST00000357008.1 ENSMUSG00000140005 (from geneSymbol) uc337quu.1 uc337quu.1 
ENSMUST00000357009.1 4930568G15Rik ENSMUST00000357009.1 4930568G15Rik (from geneSymbol) AK016251 uc337quv.1 uc337quv.1 
ENSMUST00000357018.1 ENSMUSG00000140006 ENSMUST00000357018.1 ENSMUSG00000140006 (from geneSymbol) uc337qve.1 uc337qve.1 
ENSMUST00000357025.1 ENSMUSG00000140007 ENSMUST00000357025.1 ENSMUSG00000140007 (from geneSymbol) uc337qvl.1 uc337qvl.1 
ENSMUST00000357032.1 ENSMUSG00000140008 ENSMUST00000357032.1 ENSMUSG00000140008 (from geneSymbol) uc337qvs.1 uc337qvs.1 
ENSMUST00000357036.1 Gm6213 ENSMUST00000357036.1 Gm6213 (from geneSymbol) AK080223 uc337qvw.1 uc337qvw.1 
ENSMUST00000357052.1 ENSMUSG00000140009 ENSMUST00000357052.1 ENSMUSG00000140009 (from geneSymbol) uc337qwm.1 uc337qwm.1 
ENSMUST00000357053.1 ENSMUSG00000140010 ENSMUST00000357053.1 ENSMUSG00000140010 (from geneSymbol) uc337qwn.1 uc337qwn.1 
ENSMUST00000357054.1 ENSMUSG00000140011 ENSMUST00000357054.1 ENSMUSG00000140011 (from geneSymbol) uc337qwo.1 uc337qwo.1 
ENSMUST00000357055.1 ENSMUSG00000140012 ENSMUST00000357055.1 ENSMUSG00000140012 (from geneSymbol) uc337qwp.1 uc337qwp.1 
ENSMUST00000357056.1 ENSMUSG00000140013 ENSMUST00000357056.1 ENSMUSG00000140013 (from geneSymbol) uc337qwq.1 uc337qwq.1 
ENSMUST00000357057.1 ENSMUSG00000140014 ENSMUST00000357057.1 ENSMUSG00000140014 (from geneSymbol) uc337qwr.1 uc337qwr.1 
ENSMUST00000357060.1 ENSMUSG00000140015 ENSMUST00000357060.1 ENSMUSG00000140015 (from geneSymbol) uc337qwt.1 uc337qwt.1 
ENSMUST00000357065.1 ENSMUSG00000140016 ENSMUST00000357065.1 ENSMUSG00000140016 (from geneSymbol) uc337qwy.1 uc337qwy.1 
ENSMUST00000357070.1 ENSMUSG00000140017 ENSMUST00000357070.1 ENSMUSG00000140017 (from geneSymbol) uc337qxd.1 uc337qxd.1 
ENSMUST00000357074.1 ENSMUSG00000140018 ENSMUST00000357074.1 ENSMUSG00000140018 (from geneSymbol) BC046399 uc337qxh.1 uc337qxh.1 
ENSMUST00000357075.1 2810002D19Rik ENSMUST00000357075.1 2810002D19Rik (from geneSymbol) AK012638 uc337qxi.1 uc337qxi.1 
ENSMUST00000357081.1 ENSMUSG00000140019 ENSMUST00000357081.1 ENSMUSG00000140019 (from geneSymbol) uc337qxo.1 uc337qxo.1 
ENSMUST00000357105.1 ENSMUSG00000140020 ENSMUST00000357105.1 ENSMUSG00000140020 (from geneSymbol) uc337qym.1 uc337qym.1 
ENSMUST00000357107.1 ENSMUSG00000140021 ENSMUST00000357107.1 ENSMUSG00000140021 (from geneSymbol) uc337qyo.1 uc337qyo.1 
ENSMUST00000357109.1 Gm16226 ENSMUST00000357109.1 Gm16226 (from geneSymbol) AK160425 uc337qyq.1 uc337qyq.1 
ENSMUST00000357124.1 ENSMUSG00000140022 ENSMUST00000357124.1 ENSMUSG00000140022 (from geneSymbol) uc337qzf.1 uc337qzf.1 
ENSMUST00000357131.1 ENSMUSG00000140023 ENSMUST00000357131.1 ENSMUSG00000140023 (from geneSymbol) uc337qzm.1 uc337qzm.1 
ENSMUST00000357133.1 ENSMUSG00000140024 ENSMUST00000357133.1 ENSMUSG00000140024 (from geneSymbol) uc337qzo.1 uc337qzo.1 
ENSMUST00000357134.1 ENSMUSG00000140025 ENSMUST00000357134.1 ENSMUSG00000140025 (from geneSymbol) LF300158 uc337qzp.1 uc337qzp.1 
ENSMUST00000357138.1 ENSMUSG00000140026 ENSMUST00000357138.1 ENSMUSG00000140026 (from geneSymbol) uc337qzt.1 uc337qzt.1 
ENSMUST00000357148.1 ENSMUSG00000140027 ENSMUST00000357148.1 ENSMUSG00000140027 (from geneSymbol) uc337rad.1 uc337rad.1 
ENSMUST00000357157.1 ENSMUSG00000140029 ENSMUST00000357157.1 ENSMUSG00000140029 (from geneSymbol) uc337ral.1 uc337ral.1 
ENSMUST00000357167.1 ENSMUSG00000140030 ENSMUST00000357167.1 ENSMUSG00000140030 (from geneSymbol) uc337rav.1 uc337rav.1 
ENSMUST00000357169.1 Gm11538 ENSMUST00000357169.1 Gm11538 (from geneSymbol) AK078606 uc337rax.1 uc337rax.1 
ENSMUST00000357171.1 ENSMUSG00000140031 ENSMUST00000357171.1 ENSMUSG00000140031 (from geneSymbol) uc337raz.1 uc337raz.1 
ENSMUST00000357173.1 ENSMUSG00000140032 ENSMUST00000357173.1 ENSMUSG00000140032 (from geneSymbol) uc337rbb.1 uc337rbb.1 
ENSMUST00000357216.1 ENSMUSG00000140033 ENSMUST00000357216.1 ENSMUSG00000140033 (from geneSymbol) uc337rcs.1 uc337rcs.1 
ENSMUST00000357224.1 ENSMUSG00000140034 ENSMUST00000357224.1 ENSMUSG00000140034 (from geneSymbol) uc337rda.1 uc337rda.1 
ENSMUST00000357233.1 ENSMUSG00000140035 ENSMUST00000357233.1 ENSMUSG00000140035 (from geneSymbol) uc337rdj.1 uc337rdj.1 
ENSMUST00000357236.1 4933433N18Rik ENSMUST00000357236.1 4933433N18Rik (from geneSymbol) AK017047 uc337rdm.1 uc337rdm.1 
ENSMUST00000357249.1 ENSMUSG00000140036 ENSMUST00000357249.1 ENSMUSG00000140036 (from geneSymbol) uc337rdz.1 uc337rdz.1 
ENSMUST00000357250.1 ENSMUSG00000140037 ENSMUST00000357250.1 ENSMUSG00000140037 (from geneSymbol) uc337rea.1 uc337rea.1 
ENSMUST00000357252.1 Gm20471 ENSMUST00000357252.1 Gm20471 (from geneSymbol) uc337rec.1 uc337rec.1 
ENSMUST00000357256.1 Gm16063 ENSMUST00000357256.1 Gm16063 (from geneSymbol) AK090161 uc337reg.1 uc337reg.1 
ENSMUST00000357265.1 ENSMUSG00000140038 ENSMUST00000357265.1 ENSMUSG00000140038 (from geneSymbol) uc337rep.1 uc337rep.1 
ENSMUST00000357270.1 ENSMUSG00000140039 ENSMUST00000357270.1 ENSMUSG00000140039 (from geneSymbol) uc337reu.1 uc337reu.1 
ENSMUST00000357271.1 ENSMUSG00000140040 ENSMUST00000357271.1 ENSMUSG00000140040 (from geneSymbol) uc337rev.1 uc337rev.1 
ENSMUST00000357272.1 ENSMUSG00000140041 ENSMUST00000357272.1 ENSMUSG00000140041 (from geneSymbol) uc337rew.1 uc337rew.1 
ENSMUST00000357283.1 Gm20753 ENSMUST00000357283.1 Gm20753 (from geneSymbol) BC048586 uc337rfh.1 uc337rfh.1 
ENSMUST00000357315.1 ENSMUSG00000140042 ENSMUST00000357315.1 ENSMUSG00000140042 (from geneSymbol) uc337rgn.1 uc337rgn.1 
ENSMUST00000357318.1 ENSMUSG00000140043 ENSMUST00000357318.1 ENSMUSG00000140043 (from geneSymbol) uc337rgq.1 uc337rgq.1 
ENSMUST00000357341.1 ENSMUSG00000140044 ENSMUST00000357341.1 ENSMUSG00000140044 (from geneSymbol) uc337rhn.1 uc337rhn.1 
ENSMUST00000357342.1 ENSMUSG00000140045 ENSMUST00000357342.1 ENSMUSG00000140045 (from geneSymbol) uc337rho.1 uc337rho.1 
ENSMUST00000357346.1 Gm35998 ENSMUST00000357346.1 Gm35998 (from geneSymbol) uc337rhs.1 uc337rhs.1 
ENSMUST00000357370.1 ENSMUSG00000140046 ENSMUST00000357370.1 ENSMUSG00000140046 (from geneSymbol) uc337riq.1 uc337riq.1 
ENSMUST00000357371.1 ENSMUSG00000140047 ENSMUST00000357371.1 ENSMUSG00000140047 (from geneSymbol) uc337rir.1 uc337rir.1 
ENSMUST00000357373.1 ENSMUSG00000140048 ENSMUST00000357373.1 ENSMUSG00000140048 (from geneSymbol) uc337rit.1 uc337rit.1 
ENSMUST00000357376.1 1700128F08Rik ENSMUST00000357376.1 1700128F08Rik (from geneSymbol) AK007310 uc337riw.1 uc337riw.1 
ENSMUST00000357395.1 ENSMUSG00000140049 ENSMUST00000357395.1 ENSMUSG00000140049 (from geneSymbol) uc337rjp.1 uc337rjp.1 
ENSMUST00000357396.1 ENSMUSG00000140050 ENSMUST00000357396.1 ENSMUSG00000140050 (from geneSymbol) uc337rjq.1 uc337rjq.1 
ENSMUST00000357398.1 ENSMUSG00000140051 ENSMUST00000357398.1 ENSMUSG00000140051 (from geneSymbol) uc337rjs.1 uc337rjs.1 
ENSMUST00000357399.1 Gm56713 ENSMUST00000357399.1 Gm56713 (from geneSymbol) uc337rjt.1 uc337rjt.1 
ENSMUST00000357402.1 ENSMUSG00000140052 ENSMUST00000357402.1 ENSMUSG00000140052 (from geneSymbol) uc337rjw.1 uc337rjw.1 
ENSMUST00000357407.1 ENSMUSG00000140053 ENSMUST00000357407.1 ENSMUSG00000140053 (from geneSymbol) uc337rkb.1 uc337rkb.1 
ENSMUST00000357415.1 ENSMUSG00000140054 ENSMUST00000357415.1 ENSMUSG00000140054 (from geneSymbol) uc337rkj.1 uc337rkj.1 
ENSMUST00000357416.1 Gm30779 ENSMUST00000357416.1 Gm30779 (from geneSymbol) KY468079 uc337rkk.1 uc337rkk.1 
ENSMUST00000357483.1 ENSMUSG00000140055 ENSMUST00000357483.1 ENSMUSG00000140055 (from geneSymbol) uc337rmz.1 uc337rmz.1 
ENSMUST00000357511.1 ENSMUSG00000140056 ENSMUST00000357511.1 ENSMUSG00000140056 (from geneSymbol) uc337rob.1 uc337rob.1 
ENSMUST00000357512.1 Gm46637 ENSMUST00000357512.1 Gm46637 (from geneSymbol) AK032118 uc337roc.1 uc337roc.1 
ENSMUST00000357516.1 ENSMUSG00000140058 ENSMUST00000357516.1 ENSMUSG00000140058 (from geneSymbol) uc337rof.1 uc337rof.1 
ENSMUST00000357518.1 Gm15850 ENSMUST00000357518.1 Gm15850 (from geneSymbol) AK078387 uc337roh.1 uc337roh.1 
ENSMUST00000357527.1 ENSMUSG00000140059 ENSMUST00000357527.1 ENSMUSG00000140059 (from geneSymbol) uc337roq.1 uc337roq.1 
ENSMUST00000357528.1 ENSMUSG00000140060 ENSMUST00000357528.1 ENSMUSG00000140060 (from geneSymbol) uc337ror.1 uc337ror.1 
ENSMUST00000357533.1 BB019430 ENSMUST00000357533.1 BB019430 (from geneSymbol) AK133046 uc337row.1 uc337row.1 
ENSMUST00000357553.1 ENSMUSG00000140061 ENSMUST00000357553.1 ENSMUSG00000140061 (from geneSymbol) uc337rpq.1 uc337rpq.1 
ENSMUST00000357556.1 ENSMUSG00000140062 ENSMUST00000357556.1 ENSMUSG00000140062 (from geneSymbol) uc337rpt.1 uc337rpt.1 
ENSMUST00000357558.1 ENSMUSG00000140063 ENSMUST00000357558.1 ENSMUSG00000140063 (from geneSymbol) uc337rpv.1 uc337rpv.1 
ENSMUST00000357560.1 ENSMUSG00000140064 ENSMUST00000357560.1 ENSMUSG00000140064 (from geneSymbol) uc337rpx.1 uc337rpx.1 
ENSMUST00000357561.1 Gm28417 ENSMUST00000357561.1 Gm28417 (from geneSymbol) uc337rpy.1 uc337rpy.1 
ENSMUST00000357572.1 ENSMUSG00000140065 ENSMUST00000357572.1 ENSMUSG00000140065 (from geneSymbol) uc337rqj.1 uc337rqj.1 
ENSMUST00000357578.1 ENSMUSG00000140066 ENSMUST00000357578.1 ENSMUSG00000140066 (from geneSymbol) uc337rqo.1 uc337rqo.1 
ENSMUST00000357586.1 ENSMUSG00000140067 ENSMUST00000357586.1 ENSMUSG00000140067 (from geneSymbol) uc337rqw.1 uc337rqw.1 
ENSMUST00000357595.1 ENSMUSG00000140069 ENSMUST00000357595.1 ENSMUSG00000140069 (from geneSymbol) uc337rrf.1 uc337rrf.1 
ENSMUST00000357611.1 ENSMUSG00000140070 ENSMUST00000357611.1 ENSMUSG00000140070 (from geneSymbol) uc337rrv.1 uc337rrv.1 
ENSMUST00000357621.1 ENSMUSG00000140071 ENSMUST00000357621.1 ENSMUSG00000140071 (from geneSymbol) uc337rsf.1 uc337rsf.1 
ENSMUST00000357632.1 ENSMUSG00000140072 ENSMUST00000357632.1 ENSMUSG00000140072 (from geneSymbol) uc337rsq.1 uc337rsq.1 
ENSMUST00000357633.1 ENSMUSG00000140073 ENSMUST00000357633.1 predicted gene, 52285, transcript variant 1 (from RefSeq NR_175826.1) NR_175826 uc337rsr.1 uc337rsr.1 
ENSMUST00000357634.1 ENSMUSG00000140074 ENSMUST00000357634.1 ENSMUSG00000140074 (from geneSymbol) uc337rss.1 uc337rss.1 
ENSMUST00000357639.1 Gm56509 ENSMUST00000357639.1 Gm56509 (from geneSymbol) uc337rsx.1 uc337rsx.1 
ENSMUST00000357641.1 ENSMUSG00000140075 ENSMUST00000357641.1 ENSMUSG00000140075 (from geneSymbol) uc337rsz.1 uc337rsz.1 
ENSMUST00000357643.1 ENSMUSG00000140076 ENSMUST00000357643.1 ENSMUSG00000140076 (from geneSymbol) uc337rtb.1 uc337rtb.1 
ENSMUST00000357645.1 ENSMUSG00000140077 ENSMUST00000357645.1 ENSMUSG00000140077 (from geneSymbol) uc337rtd.1 uc337rtd.1 
ENSMUST00000357666.1 ENSMUSG00000121762 ENSMUST00000357666.1 ENSMUSG00000121762 (from geneSymbol) uc337rty.1 uc337rty.1 
ENSMUST00000357667.1 ENSMUSG00000140078 ENSMUST00000357667.1 ENSMUSG00000140078 (from geneSymbol) uc337rtz.1 uc337rtz.1 
ENSMUST00000357668.1 ENSMUSG00000140079 ENSMUST00000357668.1 ENSMUSG00000140079 (from geneSymbol) uc337rua.1 uc337rua.1 
ENSMUST00000357671.1 ENSMUSG00000140080 ENSMUST00000357671.1 ENSMUSG00000140080 (from geneSymbol) uc337rud.1 uc337rud.1 
ENSMUST00000357689.1 Gm9929 ENSMUST00000357689.1 Gm9929 (from geneSymbol) AK051986 uc337ruv.1 uc337ruv.1 
ENSMUST00000357695.1 ENSMUSG00000140081 ENSMUST00000357695.1 ENSMUSG00000140081 (from geneSymbol) uc337rva.1 uc337rva.1 
ENSMUST00000357707.1 ENSMUSG00000140082 ENSMUST00000357707.1 ENSMUSG00000140082 (from geneSymbol) uc337rvm.1 uc337rvm.1 
ENSMUST00000357708.1 ENSMUSG00000140083 ENSMUST00000357708.1 ENSMUSG00000140083 (from geneSymbol) uc337rvn.1 uc337rvn.1 
ENSMUST00000357714.1 ENSMUSG00000140084 ENSMUST00000357714.1 ENSMUSG00000140084 (from geneSymbol) uc337rvt.1 uc337rvt.1 
ENSMUST00000357717.1 ENSMUSG00000140085 ENSMUST00000357717.1 ENSMUSG00000140085 (from geneSymbol) uc337rvw.1 uc337rvw.1 
ENSMUST00000357718.1 ENSMUSG00000140086 ENSMUST00000357718.1 ENSMUSG00000140086 (from geneSymbol) uc337rvx.1 uc337rvx.1 
ENSMUST00000357726.1 ENSMUSG00000140087 ENSMUST00000357726.1 ENSMUSG00000140087 (from geneSymbol) uc337rwf.1 uc337rwf.1 
ENSMUST00000357736.1 ENSMUSG00000140088 ENSMUST00000357736.1 ENSMUSG00000140088 (from geneSymbol) uc337rwp.1 uc337rwp.1 
ENSMUST00000357742.1 AI463229 ENSMUST00000357742.1 AI463229 (from geneSymbol) AK078975 uc337rwv.1 uc337rwv.1 
ENSMUST00000357802.1 ENSMUSG00000140089 ENSMUST00000357802.1 ENSMUSG00000140089 (from geneSymbol) uc337rzd.1 uc337rzd.1 
ENSMUST00000357805.1 ENSMUSG00000140090 ENSMUST00000357805.1 ENSMUSG00000140090 (from geneSymbol) uc337rzg.1 uc337rzg.1 
ENSMUST00000357806.1 ENSMUSG00000140091 ENSMUST00000357806.1 ENSMUSG00000140091 (from geneSymbol) uc337rzh.1 uc337rzh.1 
ENSMUST00000357807.1 ENSMUSG00000140092 ENSMUST00000357807.1 ENSMUSG00000140092 (from geneSymbol) uc337rzi.1 uc337rzi.1 
ENSMUST00000357812.1 ENSMUSG00000140093 ENSMUST00000357812.1 ENSMUSG00000140093 (from geneSymbol) uc337rzn.1 uc337rzn.1 
ENSMUST00000357813.1 ENSMUSG00000140094 ENSMUST00000357813.1 ENSMUSG00000140094 (from geneSymbol) uc337rzo.1 uc337rzo.1 
ENSMUST00000357814.1 ENSMUSG00000140095 ENSMUST00000357814.1 ENSMUSG00000140095 (from geneSymbol) uc337rzp.1 uc337rzp.1 
ENSMUST00000357816.1 ENSMUSG00000140096 ENSMUST00000357816.1 ENSMUSG00000140096 (from geneSymbol) uc337rzr.1 uc337rzr.1 
ENSMUST00000357817.1 ENSMUSG00000140097 ENSMUST00000357817.1 ENSMUSG00000140097 (from geneSymbol) uc337rzs.1 uc337rzs.1 
ENSMUST00000357820.1 ENSMUSG00000140098 ENSMUST00000357820.1 ENSMUSG00000140098 (from geneSymbol) uc337rzv.1 uc337rzv.1 
ENSMUST00000357824.1 ENSMUSG00000140099 ENSMUST00000357824.1 ENSMUSG00000140099 (from geneSymbol) uc337rzz.1 uc337rzz.1 
ENSMUST00000357825.1 ENSMUSG00000140100 ENSMUST00000357825.1 ENSMUSG00000140100 (from geneSymbol) uc337saa.1 uc337saa.1 
ENSMUST00000357827.1 ENSMUSG00000140101 ENSMUST00000357827.1 ENSMUSG00000140101 (from geneSymbol) uc337sac.1 uc337sac.1 
ENSMUST00000357828.1 ENSMUSG00000140102 ENSMUST00000357828.1 ENSMUSG00000140102 (from geneSymbol) uc337sad.1 uc337sad.1 
ENSMUST00000357833.1 ENSMUSG00000140103 ENSMUST00000357833.1 ENSMUSG00000140103 (from geneSymbol) uc337sai.1 uc337sai.1 
ENSMUST00000357838.1 ENSMUSG00000140104 ENSMUST00000357838.1 ENSMUSG00000140104 (from geneSymbol) uc337san.1 uc337san.1 
ENSMUST00000357841.1 ENSMUSG00000140105 ENSMUST00000357841.1 ENSMUSG00000140105 (from geneSymbol) uc337saq.1 uc337saq.1 
ENSMUST00000357842.1 ENSMUSG00000140106 ENSMUST00000357842.1 ENSMUSG00000140106 (from geneSymbol) uc337sar.1 uc337sar.1 
ENSMUST00000357844.1 ENSMUSG00000140107 ENSMUST00000357844.1 ENSMUSG00000140107 (from geneSymbol) uc337sat.1 uc337sat.1 
ENSMUST00000357846.1 ENSMUSG00000140108 ENSMUST00000357846.1 ENSMUSG00000140108 (from geneSymbol) uc337sav.1 uc337sav.1 
ENSMUST00000357850.1 ENSMUSG00000140109 ENSMUST00000357850.1 ENSMUSG00000140109 (from geneSymbol) uc337saz.1 uc337saz.1 
ENSMUST00000357861.1 ENSMUSG00000140110 ENSMUST00000357861.1 ENSMUSG00000140110 (from geneSymbol) uc337sbk.1 uc337sbk.1 
ENSMUST00000357867.1 ENSMUSG00000140112 ENSMUST00000357867.1 ENSMUSG00000140112 (from geneSymbol) uc337sbp.1 uc337sbp.1 
ENSMUST00000357869.1 ENSMUSG00000140113 ENSMUST00000357869.1 ENSMUSG00000140113 (from geneSymbol) uc337sbr.1 uc337sbr.1 
ENSMUST00000357877.1 ENSMUSG00000140114 ENSMUST00000357877.1 ENSMUSG00000140114 (from geneSymbol) uc337sbz.1 uc337sbz.1 
ENSMUST00000357888.1 ENSMUSG00000140115 ENSMUST00000357888.1 ENSMUSG00000140115 (from geneSymbol) LF200927 uc337sck.1 uc337sck.1 
ENSMUST00000357889.1 ENSMUSG00000140116 ENSMUST00000357889.1 ENSMUSG00000140116 (from geneSymbol) uc337scl.1 uc337scl.1 
ENSMUST00000357892.1 ENSMUSG00000140117 ENSMUST00000357892.1 ENSMUSG00000140117 (from geneSymbol) uc337sco.1 uc337sco.1 
ENSMUST00000357896.1 ENSMUSG00000140118 ENSMUST00000357896.1 ENSMUSG00000140118 (from geneSymbol) uc337scs.1 uc337scs.1 
ENSMUST00000357897.1 ENSMUSG00000140119 ENSMUST00000357897.1 ENSMUSG00000140119 (from geneSymbol) uc337sct.1 uc337sct.1 
ENSMUST00000357898.1 ENSMUSG00000140120 ENSMUST00000357898.1 ENSMUSG00000140120 (from geneSymbol) uc337scu.1 uc337scu.1 
ENSMUST00000357913.1 ENSMUSG00000140121 ENSMUST00000357913.1 ENSMUSG00000140121 (from geneSymbol) uc337sdj.1 uc337sdj.1 
ENSMUST00000357914.1 ENSMUSG00000140122 ENSMUST00000357914.1 ENSMUSG00000140122 (from geneSymbol) uc337sdk.1 uc337sdk.1 
ENSMUST00000357922.1 ENSMUSG00000140123 ENSMUST00000357922.1 ENSMUSG00000140123 (from geneSymbol) uc337sds.1 uc337sds.1 
ENSMUST00000357924.1 ENSMUSG00000140124 ENSMUST00000357924.1 ENSMUSG00000140124 (from geneSymbol) uc337sdu.1 uc337sdu.1 
ENSMUST00000357955.1 ENSMUSG00000140125 ENSMUST00000357955.1 ENSMUSG00000140125 (from geneSymbol) uc337sez.1 uc337sez.1 
ENSMUST00000357957.1 ENSMUSG00000140126 ENSMUST00000357957.1 ENSMUSG00000140126 (from geneSymbol) uc337sfb.1 uc337sfb.1 
ENSMUST00000357961.1 ENSMUSG00000140127 ENSMUST00000357961.1 ENSMUSG00000140127 (from geneSymbol) uc337sfd.1 uc337sfd.1 
ENSMUST00000357963.1 ENSMUSG00000140128 ENSMUST00000357963.1 ENSMUSG00000140128 (from geneSymbol) uc337sff.1 uc337sff.1 
ENSMUST00000357965.1 ENSMUSG00000140129 ENSMUST00000357965.1 ENSMUSG00000140129 (from geneSymbol) uc337sfh.1 uc337sfh.1 
ENSMUST00000357967.1 ENSMUSG00000140130 ENSMUST00000357967.1 ENSMUSG00000140130 (from geneSymbol) uc337sfj.1 uc337sfj.1 
ENSMUST00000357968.1 ENSMUSG00000140131 ENSMUST00000357968.1 ENSMUSG00000140131 (from geneSymbol) uc337sfk.1 uc337sfk.1 
ENSMUST00000357992.1 ENSMUSG00000140132 ENSMUST00000357992.1 ENSMUSG00000140132 (from geneSymbol) uc337sgi.1 uc337sgi.1 
ENSMUST00000358004.1 ENSMUSG00000140133 ENSMUST00000358004.1 ENSMUSG00000140133 (from geneSymbol) uc337sgu.1 uc337sgu.1 
ENSMUST00000358005.1 ENSMUSG00000140134 ENSMUST00000358005.1 ENSMUSG00000140134 (from geneSymbol) uc337sgv.1 uc337sgv.1 
ENSMUST00000358006.1 ENSMUSG00000140135 ENSMUST00000358006.1 ENSMUSG00000140135 (from geneSymbol) uc337sgw.1 uc337sgw.1 
ENSMUST00000358013.1 Gm6313 ENSMUST00000358013.1 Gm6313 (from geneSymbol) KY468124 uc337shd.1 uc337shd.1 
ENSMUST00000358017.1 ENSMUSG00000140136 ENSMUST00000358017.1 ENSMUSG00000140136 (from geneSymbol) uc337shh.1 uc337shh.1 
ENSMUST00000358020.1 ENSMUSG00000140137 ENSMUST00000358020.1 ENSMUSG00000140137 (from geneSymbol) uc337shk.1 uc337shk.1 
ENSMUST00000358024.1 ENSMUSG00000140138 ENSMUST00000358024.1 ENSMUSG00000140138 (from geneSymbol) uc337sho.1 uc337sho.1 
ENSMUST00000358036.1 ENSMUSG00000140139 ENSMUST00000358036.1 ENSMUSG00000140139 (from geneSymbol) uc337sia.1 uc337sia.1 
ENSMUST00000358041.1 ENSMUSG00000140140 ENSMUST00000358041.1 ENSMUSG00000140140 (from geneSymbol) uc337sif.1 uc337sif.1 
ENSMUST00000358046.1 ENSMUSG00000140141 ENSMUST00000358046.1 ENSMUSG00000140141 (from geneSymbol) uc337sik.1 uc337sik.1 
ENSMUST00000358048.1 ENSMUSG00000140142 ENSMUST00000358048.1 ENSMUSG00000140142 (from geneSymbol) uc337sim.1 uc337sim.1 
ENSMUST00000358050.1 ENSMUSG00000140143 ENSMUST00000358050.1 ENSMUSG00000140143 (from geneSymbol) uc337sio.1 uc337sio.1 
ENSMUST00000358057.1 Gm31458 ENSMUST00000358057.1 Gm31458 (from geneSymbol) uc337siv.1 uc337siv.1 
ENSMUST00000358094.1 ENSMUSG00000140144 ENSMUST00000358094.1 ENSMUSG00000140144 (from geneSymbol) uc337skg.1 uc337skg.1 
ENSMUST00000358096.1 ENSMUSG00000140145 ENSMUST00000358096.1 ENSMUSG00000140145 (from geneSymbol) uc337ski.1 uc337ski.1 
ENSMUST00000358101.1 Gm4349 ENSMUST00000358101.1 Gm4349 (from geneSymbol) AK050745 uc337skn.1 uc337skn.1 
ENSMUST00000358127.1 ENSMUSG00000140146 ENSMUST00000358127.1 ENSMUSG00000140146 (from geneSymbol) uc337sln.1 uc337sln.1 
ENSMUST00000358129.1 ENSMUSG00000140147 ENSMUST00000358129.1 ENSMUSG00000140147 (from geneSymbol) uc337slp.1 uc337slp.1 
ENSMUST00000358133.1 ENSMUSG00000140148 ENSMUST00000358133.1 ENSMUSG00000140148 (from geneSymbol) uc337slt.1 uc337slt.1 
ENSMUST00000358137.1 ENSMUSG00000140149 ENSMUST00000358137.1 ENSMUSG00000140149 (from geneSymbol) uc337slx.1 uc337slx.1 
ENSMUST00000358145.1 ENSMUSG00000140150 ENSMUST00000358145.1 ENSMUSG00000140150 (from geneSymbol) uc337smf.1 uc337smf.1 
ENSMUST00000358146.1 ENSMUSG00000140151 ENSMUST00000358146.1 ENSMUSG00000140151 (from geneSymbol) uc337smg.1 uc337smg.1 
ENSMUST00000358148.1 ENSMUSG00000140152 ENSMUST00000358148.1 ENSMUSG00000140152 (from geneSymbol) uc337smi.1 uc337smi.1 
ENSMUST00000358155.1 ENSMUSG00000140153 ENSMUST00000358155.1 ENSMUSG00000140153 (from geneSymbol) uc337smp.1 uc337smp.1 
ENSMUST00000358158.1 ENSMUSG00000140154 ENSMUST00000358158.1 ENSMUSG00000140154 (from geneSymbol) AK018904 uc337sms.1 uc337sms.1 
ENSMUST00000358159.1 D830036C21Rik ENSMUST00000358159.1 D830036C21Rik (from geneSymbol) uc337smt.1 uc337smt.1 
ENSMUST00000358163.1 ENSMUSG00000140155 ENSMUST00000358163.1 ENSMUSG00000140155 (from geneSymbol) uc337smx.1 uc337smx.1 
ENSMUST00000358164.1 ENSMUSG00000140156 ENSMUST00000358164.1 ENSMUSG00000140156 (from geneSymbol) uc337smy.1 uc337smy.1 
ENSMUST00000358165.1 ENSMUSG00000140157 ENSMUST00000358165.1 ENSMUSG00000140157 (from geneSymbol) uc337smz.1 uc337smz.1 
ENSMUST00000358166.1 ENSMUSG00000140158 ENSMUST00000358166.1 ENSMUSG00000140158 (from geneSymbol) uc337sna.1 uc337sna.1 
ENSMUST00000358167.1 ENSMUSG00000140159 ENSMUST00000358167.1 ENSMUSG00000140159 (from geneSymbol) uc337snb.1 uc337snb.1 
ENSMUST00000358177.1 ENSMUSG00000140160 ENSMUST00000358177.1 ENSMUSG00000140160 (from geneSymbol) uc337snl.1 uc337snl.1 
ENSMUST00000358179.1 ENSMUSG00000140161 ENSMUST00000358179.1 ENSMUSG00000140161 (from geneSymbol) uc337snn.1 uc337snn.1 
ENSMUST00000358182.1 ENSMUSG00000140162 ENSMUST00000358182.1 ENSMUSG00000140162 (from geneSymbol) uc337snq.1 uc337snq.1 
ENSMUST00000358187.1 ENSMUSG00000140163 ENSMUST00000358187.1 ENSMUSG00000140163 (from geneSymbol) uc337snv.1 uc337snv.1 
ENSMUST00000358189.1 ENSMUSG00000140164 ENSMUST00000358189.1 ENSMUSG00000140164 (from geneSymbol) uc337snx.1 uc337snx.1 
ENSMUST00000358190.1 ENSMUSG00000140165 ENSMUST00000358190.1 ENSMUSG00000140165 (from geneSymbol) uc337sny.1 uc337sny.1 
ENSMUST00000358191.1 ENSMUSG00000140166 ENSMUST00000358191.1 ENSMUSG00000140166 (from geneSymbol) EF651834 uc337snz.1 uc337snz.1 
ENSMUST00000358192.1 ENSMUSG00000140167 ENSMUST00000358192.1 ENSMUSG00000140167 (from geneSymbol) uc337soa.1 uc337soa.1 
ENSMUST00000358195.1 Gm36231 ENSMUST00000358195.1 Gm36231 (from geneSymbol) uc337sod.1 uc337sod.1 
ENSMUST00000358201.1 4930405H06Rik ENSMUST00000358201.1 4930405H06Rik (from geneSymbol) AK015098 uc337soj.1 uc337soj.1 
ENSMUST00000358203.1 ENSMUSG00000140168 ENSMUST00000358203.1 ENSMUSG00000140168 (from geneSymbol) uc337sol.1 uc337sol.1 
ENSMUST00000358205.1 ENSMUSG00000140169 ENSMUST00000358205.1 ENSMUSG00000140169 (from geneSymbol) uc337son.1 uc337son.1 
ENSMUST00000358215.1 ENSMUSG00000140170 ENSMUST00000358215.1 ENSMUSG00000140170 (from geneSymbol) uc337sox.1 uc337sox.1 
ENSMUST00000358219.1 ENSMUSG00000140171 ENSMUST00000358219.1 ENSMUSG00000140171 (from geneSymbol) uc337spb.1 uc337spb.1 
ENSMUST00000358221.1 ENSMUSG00000140172 ENSMUST00000358221.1 ENSMUSG00000140172 (from geneSymbol) uc337spd.1 uc337spd.1 
ENSMUST00000358230.1 ENSMUSG00000140173 ENSMUST00000358230.1 ENSMUSG00000140173 (from geneSymbol) uc337spm.1 uc337spm.1 
ENSMUST00000358232.1 ENSMUSG00000140174 ENSMUST00000358232.1 ENSMUSG00000140174 (from geneSymbol) uc337spo.1 uc337spo.1 
ENSMUST00000358233.1 ENSMUSG00000140175 ENSMUST00000358233.1 ENSMUSG00000140175 (from geneSymbol) uc337spp.1 uc337spp.1 
ENSMUST00000358234.1 ENSMUSG00000140176 ENSMUST00000358234.1 ENSMUSG00000140176 (from geneSymbol) uc337spq.1 uc337spq.1 
ENSMUST00000358236.1 ENSMUSG00000140177 ENSMUST00000358236.1 ENSMUSG00000140177 (from geneSymbol) uc337sps.1 uc337sps.1 
ENSMUST00000358238.1 ENSMUSG00000140178 ENSMUST00000358238.1 ENSMUSG00000140178 (from geneSymbol) uc337spu.1 uc337spu.1 
ENSMUST00000358241.1 ENSMUSG00000140179 ENSMUST00000358241.1 ENSMUSG00000140179 (from geneSymbol) uc337spx.1 uc337spx.1 
ENSMUST00000358242.1 ENSMUSG00000140180 ENSMUST00000358242.1 ENSMUSG00000140180 (from geneSymbol) uc337spy.1 uc337spy.1 
ENSMUST00000358243.1 ENSMUSG00000140181 ENSMUST00000358243.1 ENSMUSG00000140181 (from geneSymbol) uc337spz.1 uc337spz.1 
ENSMUST00000358246.1 Gm56523 ENSMUST00000358246.1 Gm56523 (from geneSymbol) uc337sqc.1 uc337sqc.1 
ENSMUST00000358253.1 ENSMUSG00000140182 ENSMUST00000358253.1 ENSMUSG00000140182 (from geneSymbol) uc337sqj.1 uc337sqj.1 
ENSMUST00000358254.1 ENSMUSG00000140183 ENSMUST00000358254.1 ENSMUSG00000140183 (from geneSymbol) uc337sqk.1 uc337sqk.1 
ENSMUST00000358255.1 ENSMUSG00000140184 ENSMUST00000358255.1 ENSMUSG00000140184 (from geneSymbol) uc337sql.1 uc337sql.1 
ENSMUST00000358256.1 ENSMUSG00000140185 ENSMUST00000358256.1 ENSMUSG00000140185 (from geneSymbol) uc337sqm.1 uc337sqm.1 
ENSMUST00000358257.1 Gm45680 ENSMUST00000358257.1 Gm45680 (from geneSymbol) uc337sqn.1 uc337sqn.1 
ENSMUST00000358260.1 ENSMUSG00000140186 ENSMUST00000358260.1 ENSMUSG00000140186 (from geneSymbol) uc337sqq.1 uc337sqq.1 
ENSMUST00000358261.1 ENSMUSG00000140187 ENSMUST00000358261.1 ENSMUSG00000140187 (from geneSymbol) uc337sqr.1 uc337sqr.1 
ENSMUST00000358264.1 Gm13383 ENSMUST00000358264.1 Gm13383 (from geneSymbol) AK043615 uc337squ.1 uc337squ.1 
ENSMUST00000358268.1 ENSMUSG00000140188 ENSMUST00000358268.1 ENSMUSG00000140188 (from geneSymbol) uc337sqy.1 uc337sqy.1 
ENSMUST00000358270.1 ENSMUSG00000140189 ENSMUST00000358270.1 ENSMUSG00000140189 (from geneSymbol) uc337sra.1 uc337sra.1 
ENSMUST00000358273.1 4930488L21Rik ENSMUST00000358273.1 4930488L21Rik (from geneSymbol) AK038973 uc337srd.1 uc337srd.1 
ENSMUST00000358289.1 ENSMUSG00000140190 ENSMUST00000358289.1 ENSMUSG00000140190 (from geneSymbol) uc337srt.1 uc337srt.1 
ENSMUST00000358290.1 Gm57421 ENSMUST00000358290.1 Gm57421 (from geneSymbol) uc337sru.1 uc337sru.1 
ENSMUST00000358295.1 ENSMUSG00000140191 ENSMUST00000358295.1 ENSMUSG00000140191 (from geneSymbol) uc337srz.1 uc337srz.1 
ENSMUST00000358318.1 ENSMUSG00000140192 ENSMUST00000358318.1 ENSMUSG00000140192 (from geneSymbol) uc337ssw.1 uc337ssw.1 
ENSMUST00000358319.1 ENSMUSG00000140193 ENSMUST00000358319.1 ENSMUSG00000140193 (from geneSymbol) uc337ssx.1 uc337ssx.1 
ENSMUST00000358321.1 ENSMUSG00000140194 ENSMUST00000358321.1 ENSMUSG00000140194 (from geneSymbol) uc337ssz.1 uc337ssz.1 
ENSMUST00000358324.1 Gm57200 ENSMUST00000358324.1 Gm57200 (from geneSymbol) BC044776 uc337stc.1 uc337stc.1 
ENSMUST00000358346.1 ENSMUSG00000140195 ENSMUST00000358346.1 ENSMUSG00000140195 (from geneSymbol) uc337sty.1 uc337sty.1 
ENSMUST00000358353.1 ENSMUSG00000140196 ENSMUST00000358353.1 ENSMUSG00000140196 (from geneSymbol) uc337suf.1 uc337suf.1 
ENSMUST00000358377.1 ENSMUSG00000140197 ENSMUST00000358377.1 ENSMUSG00000140197 (from geneSymbol) uc337svd.1 uc337svd.1 
ENSMUST00000358407.1 ENSMUSG00000140199 ENSMUST00000358407.1 ENSMUSG00000140199 (from geneSymbol) uc337svs.1 uc337svs.1 
ENSMUST00000358412.1 ENSMUSG00000140200 ENSMUST00000358412.1 ENSMUSG00000140200 (from geneSymbol) uc337svx.1 uc337svx.1 
ENSMUST00000358415.1 4933416O17Rik ENSMUST00000358415.1 4933416O17Rik (from geneSymbol) AK015718 uc337swa.1 uc337swa.1 
ENSMUST00000358428.1 ENSMUSG00000140201 ENSMUST00000358428.1 ENSMUSG00000140201 (from geneSymbol) uc337swn.1 uc337swn.1 
ENSMUST00000358431.1 ENSMUSG00000140202 ENSMUST00000358431.1 ENSMUSG00000140202 (from geneSymbol) uc337swq.1 uc337swq.1 
ENSMUST00000358433.1 ENSMUSG00000140203 ENSMUST00000358433.1 ENSMUSG00000140203 (from geneSymbol) uc337sws.1 uc337sws.1 
ENSMUST00000358436.1 ENSMUSG00000140204 ENSMUST00000358436.1 ENSMUSG00000140204 (from geneSymbol) uc337swv.1 uc337swv.1 
ENSMUST00000358438.1 ENSMUSG00000140205 ENSMUST00000358438.1 ENSMUSG00000140205 (from geneSymbol) uc337swx.1 uc337swx.1 
ENSMUST00000358439.1 ENSMUSG00000140206 ENSMUST00000358439.1 ENSMUSG00000140206 (from geneSymbol) uc337swy.1 uc337swy.1 
ENSMUST00000358440.1 ENSMUSG00000140207 ENSMUST00000358440.1 ENSMUSG00000140207 (from geneSymbol) AK005917 uc337swz.1 uc337swz.1 
ENSMUST00000358441.1 ENSMUSG00000140208 ENSMUST00000358441.1 ENSMUSG00000140208 (from geneSymbol) uc337sxa.1 uc337sxa.1 
ENSMUST00000358442.1 ENSMUSG00000140209 ENSMUST00000358442.1 ENSMUSG00000140209 (from geneSymbol) uc337sxb.1 uc337sxb.1 
ENSMUST00000358444.1 ENSMUSG00000140210 ENSMUST00000358444.1 ENSMUSG00000140210 (from geneSymbol) uc337sxd.1 uc337sxd.1 
ENSMUST00000358445.1 ENSMUSG00000140211 ENSMUST00000358445.1 ENSMUSG00000140211 (from geneSymbol) uc337sxe.1 uc337sxe.1 
ENSMUST00000358448.1 ENSMUSG00000140212 ENSMUST00000358448.1 ENSMUSG00000140212 (from geneSymbol) uc337sxh.1 uc337sxh.1 
ENSMUST00000358449.1 ENSMUSG00000140213 ENSMUST00000358449.1 ENSMUSG00000140213 (from geneSymbol) uc337sxi.1 uc337sxi.1 
ENSMUST00000358452.1 ENSMUSG00000140214 ENSMUST00000358452.1 ENSMUSG00000140214 (from geneSymbol) uc337sxl.1 uc337sxl.1 
ENSMUST00000358453.1 ENSMUSG00000140215 ENSMUST00000358453.1 ENSMUSG00000140215 (from geneSymbol) uc337sxm.1 uc337sxm.1 
ENSMUST00000358454.1 ENSMUSG00000140216 ENSMUST00000358454.1 ENSMUSG00000140216 (from geneSymbol) uc337sxn.1 uc337sxn.1 
ENSMUST00000358458.1 Gm15461 ENSMUST00000358458.1 Gm15461 (from geneSymbol) uc337sxr.1 uc337sxr.1 
ENSMUST00000358463.1 ENSMUSG00000140217 ENSMUST00000358463.1 ENSMUSG00000140217 (from geneSymbol) uc337sxw.1 uc337sxw.1 
ENSMUST00000358470.1 Gm26698 ENSMUST00000358470.1 Gm26698 (from geneSymbol) uc337syd.1 uc337syd.1 
ENSMUST00000358476.1 ENSMUSG00000140219 ENSMUST00000358476.1 ENSMUSG00000140219 (from geneSymbol) uc337syj.1 uc337syj.1 
ENSMUST00000358479.1 ENSMUSG00000140220 ENSMUST00000358479.1 ENSMUSG00000140220 (from geneSymbol) uc337sym.1 uc337sym.1 
ENSMUST00000358480.1 ENSMUSG00000140221 ENSMUST00000358480.1 ENSMUSG00000140221 (from geneSymbol) uc337syn.1 uc337syn.1 
ENSMUST00000358481.1 ENSMUSG00000140222 ENSMUST00000358481.1 ENSMUSG00000140222 (from geneSymbol) uc337syo.1 uc337syo.1 
ENSMUST00000358482.1 ENSMUSG00000140223 ENSMUST00000358482.1 ENSMUSG00000140223 (from geneSymbol) uc337syp.1 uc337syp.1 
ENSMUST00000358487.1 ENSMUSG00000140224 ENSMUST00000358487.1 ENSMUSG00000140224 (from geneSymbol) uc337syu.1 uc337syu.1 
ENSMUST00000358492.1 ENSMUSG00000140225 ENSMUST00000358492.1 ENSMUSG00000140225 (from geneSymbol) uc337syz.1 uc337syz.1 
ENSMUST00000358495.1 ENSMUSG00000140226 ENSMUST00000358495.1 ENSMUSG00000140226 (from geneSymbol) uc337szc.1 uc337szc.1 
ENSMUST00000358496.1 ENSMUSG00000140227 ENSMUST00000358496.1 ENSMUSG00000140227 (from geneSymbol) uc337szd.1 uc337szd.1 
ENSMUST00000358499.1 3110015C05Rik ENSMUST00000358499.1 3110015C05Rik (from geneSymbol) AK014052 uc337szg.1 uc337szg.1 
ENSMUST00000358522.1 ENSMUSG00000140228 ENSMUST00000358522.1 ENSMUSG00000140228 (from geneSymbol) uc337tad.1 uc337tad.1 
ENSMUST00000358534.1 ENSMUSG00000140229 ENSMUST00000358534.1 ENSMUSG00000140229 (from geneSymbol) uc337tap.1 uc337tap.1 
ENSMUST00000358547.1 ENSMUSG00000140230 ENSMUST00000358547.1 ENSMUSG00000140230 (from geneSymbol) uc337tbc.1 uc337tbc.1 
ENSMUST00000358548.1 ENSMUSG00000140231 ENSMUST00000358548.1 ENSMUSG00000140231 (from geneSymbol) AK148606 uc337tbd.1 uc337tbd.1 
ENSMUST00000358550.1 Gm20468 ENSMUST00000358550.1 Gm20468 (from geneSymbol) KY467777 uc337tbf.1 uc337tbf.1 
ENSMUST00000358563.1 ENSMUSG00000140232 ENSMUST00000358563.1 ENSMUSG00000140232 (from geneSymbol) uc337tbs.1 uc337tbs.1 
ENSMUST00000358571.1 Gm35409 ENSMUST00000358571.1 Gm35409 (from geneSymbol) KY467954 uc337tca.1 uc337tca.1 
ENSMUST00000358574.1 ENSMUSG00000140233 ENSMUST00000358574.1 ENSMUSG00000140233 (from geneSymbol) uc337tcd.1 uc337tcd.1 
ENSMUST00000358581.1 ENSMUSG00000140234 ENSMUST00000358581.1 ENSMUSG00000140234 (from geneSymbol) uc337tck.1 uc337tck.1 
ENSMUST00000358582.1 ENSMUSG00000140235 ENSMUST00000358582.1 ENSMUSG00000140235 (from geneSymbol) uc337tcl.1 uc337tcl.1 
ENSMUST00000358588.1 ENSMUSG00000140236 ENSMUST00000358588.1 ENSMUSG00000140236 (from geneSymbol) uc337tcr.1 uc337tcr.1 
ENSMUST00000358590.1 ENSMUSG00000121351 ENSMUST00000358590.1 ENSMUSG00000121351 (from geneSymbol) uc337tct.1 uc337tct.1 
ENSMUST00000358596.1 ENSMUSG00000140238 ENSMUST00000358596.1 ENSMUSG00000140238 (from geneSymbol) uc337tcy.1 uc337tcy.1 
ENSMUST00000358597.1 ENSMUSG00000140239 ENSMUST00000358597.1 ENSMUSG00000140239 (from geneSymbol) uc337tcz.1 uc337tcz.1 
ENSMUST00000358602.1 ENSMUSG00000140240 ENSMUST00000358602.1 ENSMUSG00000140240 (from geneSymbol) uc337tde.1 uc337tde.1 
ENSMUST00000358611.1 Gm35172 ENSMUST00000358611.1 Gm35172 (from geneSymbol) uc337tdn.1 uc337tdn.1 
ENSMUST00000358617.1 ENSMUSG00000140242 ENSMUST00000358617.1 ENSMUSG00000140242 (from geneSymbol) uc337tdr.1 uc337tdr.1 
ENSMUST00000358618.1 Cntrobos ENSMUST00000358618.1 Cntrobos (from geneSymbol) uc337tds.1 uc337tds.1 
ENSMUST00000358619.1 ENSMUSG00000140243 ENSMUST00000358619.1 ENSMUSG00000140243 (from geneSymbol) uc337tdt.1 uc337tdt.1 
ENSMUST00000358620.1 ENSMUSG00000140244 ENSMUST00000358620.1 ENSMUSG00000140244 (from geneSymbol) uc337tdu.1 uc337tdu.1 
ENSMUST00000358624.1 ENSMUSG00000140245 ENSMUST00000358624.1 ENSMUSG00000140245 (from geneSymbol) uc337tdy.1 uc337tdy.1 
ENSMUST00000358627.1 ENSMUSG00000140246 ENSMUST00000358627.1 ENSMUSG00000140246 (from geneSymbol) uc337teb.1 uc337teb.1 
ENSMUST00000358636.1 ENSMUSG00000140247 ENSMUST00000358636.1 ENSMUSG00000140247 (from geneSymbol) uc337tek.1 uc337tek.1 
ENSMUST00000358639.1 Gm31784 ENSMUST00000358639.1 Gm31784 (from geneSymbol) uc337ten.1 uc337ten.1 
ENSMUST00000358646.1 ENSMUSG00000140248 ENSMUST00000358646.1 ENSMUSG00000140248 (from geneSymbol) uc337teu.1 uc337teu.1 
ENSMUST00000358648.1 ENSMUSG00000140249 ENSMUST00000358648.1 ENSMUSG00000140249 (from geneSymbol) uc337tew.1 uc337tew.1 
ENSMUST00000358649.1 ENSMUSG00000140250 ENSMUST00000358649.1 ENSMUSG00000140250 (from geneSymbol) uc337tex.1 uc337tex.1 
ENSMUST00000358656.1 ENSMUSG00000140251 ENSMUST00000358656.1 ENSMUSG00000140251 (from geneSymbol) uc337tfe.1 uc337tfe.1 
ENSMUST00000358659.1 ENSMUSG00000140252 ENSMUST00000358659.1 ENSMUSG00000140252 (from geneSymbol) uc337tfg.1 uc337tfg.1 
ENSMUST00000358661.1 ENSMUSG00000140253 ENSMUST00000358661.1 ENSMUSG00000140253 (from geneSymbol) uc337tfi.1 uc337tfi.1 
ENSMUST00000358663.1 ENSMUSG00000140254 ENSMUST00000358663.1 ENSMUSG00000140254 (from geneSymbol) uc337tfk.1 uc337tfk.1 
ENSMUST00000358666.1 1700016K05Rik ENSMUST00000358666.1 1700016K05Rik (from geneSymbol) AK006039 uc337tfn.1 uc337tfn.1 
ENSMUST00000358674.1 ENSMUSG00000140255 ENSMUST00000358674.1 ENSMUSG00000140255 (from geneSymbol) uc337tfv.1 uc337tfv.1 
ENSMUST00000358677.1 ENSMUSG00000140256 ENSMUST00000358677.1 ENSMUSG00000140256 (from geneSymbol) uc337tfy.1 uc337tfy.1 
ENSMUST00000358681.1 ENSMUSG00000140257 ENSMUST00000358681.1 ENSMUSG00000140257 (from geneSymbol) uc337tgc.1 uc337tgc.1 
ENSMUST00000358682.1 ENSMUSG00000140258 ENSMUST00000358682.1 ENSMUSG00000140258 (from geneSymbol) uc337tgd.1 uc337tgd.1 
ENSMUST00000358685.1 9330151L19Rik ENSMUST00000358685.1 9330151L19Rik (from geneSymbol) uc337tgg.1 uc337tgg.1 
ENSMUST00000358690.1 ENSMUSG00000140259 ENSMUST00000358690.1 ENSMUSG00000140259 (from geneSymbol) uc337tgl.1 uc337tgl.1 
ENSMUST00000358691.1 ENSMUSG00000140260 ENSMUST00000358691.1 ENSMUSG00000140260 (from geneSymbol) uc337tgm.1 uc337tgm.1 
ENSMUST00000358692.1 ENSMUSG00000140261 ENSMUST00000358692.1 ENSMUSG00000140261 (from geneSymbol) uc337tgn.1 uc337tgn.1 
ENSMUST00000358693.1 ENSMUSG00000140262 ENSMUST00000358693.1 ENSMUSG00000140262 (from geneSymbol) uc337tgo.1 uc337tgo.1 
ENSMUST00000358699.1 ENSMUSG00000140263 ENSMUST00000358699.1 ENSMUSG00000140263 (from geneSymbol) uc337tgu.1 uc337tgu.1 
ENSMUST00000358701.1 ENSMUSG00000140264 ENSMUST00000358701.1 ENSMUSG00000140264 (from geneSymbol) uc337tgw.1 uc337tgw.1 
ENSMUST00000358702.1 ENSMUSG00000140265 ENSMUST00000358702.1 ENSMUSG00000140265 (from geneSymbol) uc337tgx.1 uc337tgx.1 
ENSMUST00000358703.1 ENSMUSG00000140266 ENSMUST00000358703.1 ENSMUSG00000140266 (from geneSymbol) uc337tgy.1 uc337tgy.1 
ENSMUST00000358704.1 ENSMUSG00000140267 ENSMUST00000358704.1 ENSMUSG00000140267 (from geneSymbol) uc337tgz.1 uc337tgz.1 
ENSMUST00000358705.1 ENSMUSG00000140268 ENSMUST00000358705.1 ENSMUSG00000140268 (from geneSymbol) uc337tha.1 uc337tha.1 
ENSMUST00000358707.1 ENSMUSG00000140269 ENSMUST00000358707.1 ENSMUSG00000140269 (from geneSymbol) uc337thc.1 uc337thc.1 
ENSMUST00000358709.1 ENSMUSG00000140270 ENSMUST00000358709.1 ENSMUSG00000140270 (from geneSymbol) AK076840 uc337the.1 uc337the.1 
ENSMUST00000358714.1 Gm17382 ENSMUST00000358714.1 Gm17382 (from geneSymbol) AK031813 uc337thj.1 uc337thj.1 
ENSMUST00000358719.1 ENSMUSG00000140271 ENSMUST00000358719.1 ENSMUSG00000140271 (from geneSymbol) uc337tho.1 uc337tho.1 
ENSMUST00000358720.1 ENSMUSG00000140272 ENSMUST00000358720.1 ENSMUSG00000140272 (from geneSymbol) uc337thp.1 uc337thp.1 
ENSMUST00000358723.1 ENSMUSG00000140273 ENSMUST00000358723.1 ENSMUSG00000140273 (from geneSymbol) uc337ths.1 uc337ths.1 
ENSMUST00000358724.1 ENSMUSG00000140274 ENSMUST00000358724.1 ENSMUSG00000140274 (from geneSymbol) uc337tht.1 uc337tht.1 
ENSMUST00000358726.1 ENSMUSG00000140275 ENSMUST00000358726.1 ENSMUSG00000140275 (from geneSymbol) uc337thv.1 uc337thv.1 
ENSMUST00000358730.1 ENSMUSG00000140276 ENSMUST00000358730.1 ENSMUSG00000140276 (from geneSymbol) uc337thz.1 uc337thz.1 
ENSMUST00000358740.1 ENSMUSG00000140277 ENSMUST00000358740.1 ENSMUSG00000140277 (from geneSymbol) uc337tij.1 uc337tij.1 
ENSMUST00000358747.1 ENSMUSG00000140278 ENSMUST00000358747.1 ENSMUSG00000140278 (from geneSymbol) uc337tiq.1 uc337tiq.1 
ENSMUST00000358748.1 ENSMUSG00000140279 ENSMUST00000358748.1 ENSMUSG00000140279 (from geneSymbol) uc337tir.1 uc337tir.1 
ENSMUST00000358767.1 Gm50291 ENSMUST00000358767.1 Gm50291 (from geneSymbol) uc337tjj.1 uc337tjj.1 
ENSMUST00000358771.1 ENSMUSG00000140280 ENSMUST00000358771.1 ENSMUSG00000140280 (from geneSymbol) uc337tjn.1 uc337tjn.1 
ENSMUST00000358772.1 ENSMUSG00000140281 ENSMUST00000358772.1 ENSMUSG00000140281 (from geneSymbol) uc337tjo.1 uc337tjo.1 
ENSMUST00000358777.1 Gm49018 ENSMUST00000358777.1 Gm49018 (from geneSymbol) KY467712 uc337tjt.1 uc337tjt.1 
ENSMUST00000358800.1 ENSMUSG00000140282 ENSMUST00000358800.1 ENSMUSG00000140282 (from geneSymbol) uc337tkq.1 uc337tkq.1 
ENSMUST00000358801.1 Gm14029 ENSMUST00000358801.1 Gm14029 (from geneSymbol) AK079941 uc337tkr.1 uc337tkr.1 
ENSMUST00000358805.1 ENSMUSG00000140283 ENSMUST00000358805.1 ENSMUSG00000140283 (from geneSymbol) uc337tkv.1 uc337tkv.1 
ENSMUST00000358806.1 ENSMUSG00000140284 ENSMUST00000358806.1 ENSMUSG00000140284 (from geneSymbol) uc337tkw.1 uc337tkw.1 
ENSMUST00000358807.1 ENSMUSG00000140285 ENSMUST00000358807.1 ENSMUSG00000140285 (from geneSymbol) uc337tkx.1 uc337tkx.1 
ENSMUST00000358808.1 ENSMUSG00000140286 ENSMUST00000358808.1 ENSMUSG00000140286 (from geneSymbol) uc337tky.1 uc337tky.1 
ENSMUST00000358809.1 ENSMUSG00000140287 ENSMUST00000358809.1 ENSMUSG00000140287 (from geneSymbol) uc337tkz.1 uc337tkz.1 
ENSMUST00000358810.1 ENSMUSG00000140288 ENSMUST00000358810.1 ENSMUSG00000140288 (from geneSymbol) uc337tla.1 uc337tla.1 
ENSMUST00000358838.1 ENSMUSG00000140289 ENSMUST00000358838.1 ENSMUSG00000140289 (from geneSymbol) uc337tmb.1 uc337tmb.1 
ENSMUST00000358839.1 ENSMUSG00000140290 ENSMUST00000358839.1 ENSMUSG00000140290 (from geneSymbol) uc337tmc.1 uc337tmc.1 
ENSMUST00000358854.1 ENSMUSG00000140291 ENSMUST00000358854.1 ENSMUSG00000140291 (from geneSymbol) uc337tmr.1 uc337tmr.1 
ENSMUST00000358863.1 ENSMUSG00000140292 ENSMUST00000358863.1 ENSMUSG00000140292 (from geneSymbol) uc337tna.1 uc337tna.1 
ENSMUST00000358864.1 ENSMUSG00000140293 ENSMUST00000358864.1 ENSMUSG00000140293 (from geneSymbol) uc337tnb.1 uc337tnb.1 
ENSMUST00000358865.1 ENSMUSG00000140294 ENSMUST00000358865.1 ENSMUSG00000140294 (from geneSymbol) AK136239 uc337tnc.1 uc337tnc.1 
ENSMUST00000358867.1 Gm16351 ENSMUST00000358867.1 Gm16351 (from geneSymbol) uc337tne.1 uc337tne.1 
ENSMUST00000358891.1 ENSMUSG00000140295 ENSMUST00000358891.1 ENSMUSG00000140295 (from geneSymbol) uc337toc.1 uc337toc.1 
ENSMUST00000358892.1 ENSMUSG00000140296 ENSMUST00000358892.1 ENSMUSG00000140296 (from geneSymbol) uc337tod.1 uc337tod.1 
ENSMUST00000358893.1 ENSMUSG00000140297 ENSMUST00000358893.1 ENSMUSG00000140297 (from geneSymbol) uc337toe.1 uc337toe.1 
ENSMUST00000358894.1 ENSMUSG00000140298 ENSMUST00000358894.1 ENSMUSG00000140298 (from geneSymbol) uc337tof.1 uc337tof.1 
ENSMUST00000358895.1 ENSMUSG00000140299 ENSMUST00000358895.1 ENSMUSG00000140299 (from geneSymbol) uc337tog.1 uc337tog.1 
ENSMUST00000358899.1 ENSMUSG00000140300 ENSMUST00000358899.1 ENSMUSG00000140300 (from geneSymbol) uc337tok.1 uc337tok.1 
ENSMUST00000358900.1 ENSMUSG00000140301 ENSMUST00000358900.1 ENSMUSG00000140301 (from geneSymbol) uc337tol.1 uc337tol.1 
ENSMUST00000358901.1 Gm11309 ENSMUST00000358901.1 Gm11309 (from geneSymbol) uc337tom.1 uc337tom.1 
ENSMUST00000358905.1 ENSMUSG00000140302 ENSMUST00000358905.1 ENSMUSG00000140302 (from geneSymbol) uc337toq.1 uc337toq.1 
ENSMUST00000358906.1 ENSMUSG00000140303 ENSMUST00000358906.1 ENSMUSG00000140303 (from geneSymbol) uc337tor.1 uc337tor.1 
ENSMUST00000358907.1 ENSMUSG00000140304 ENSMUST00000358907.1 ENSMUSG00000140304 (from geneSymbol) uc337tos.1 uc337tos.1 
ENSMUST00000358909.1 ENSMUSG00000140306 ENSMUST00000358909.1 ENSMUSG00000140306 (from geneSymbol) uc337tot.1 uc337tot.1 
ENSMUST00000358912.1 ENSMUSG00000140307 ENSMUST00000358912.1 ENSMUSG00000140307 (from geneSymbol) uc337tow.1 uc337tow.1 
ENSMUST00000358920.1 ENSMUSG00000140308 ENSMUST00000358920.1 ENSMUSG00000140308 (from geneSymbol) uc337tpe.1 uc337tpe.1 
ENSMUST00000358921.1 ENSMUSG00000140309 ENSMUST00000358921.1 ENSMUSG00000140309 (from geneSymbol) uc337tpf.1 uc337tpf.1 
ENSMUST00000358922.1 ENSMUSG00000140310 ENSMUST00000358922.1 ENSMUSG00000140310 (from geneSymbol) uc337tpg.1 uc337tpg.1 
ENSMUST00000358927.1 ENSMUSG00000140311 ENSMUST00000358927.1 ENSMUSG00000140311 (from geneSymbol) uc337tpl.1 uc337tpl.1 
ENSMUST00000358929.1 ENSMUSG00000140312 ENSMUST00000358929.1 ENSMUSG00000140312 (from geneSymbol) uc337tpn.1 uc337tpn.1 
ENSMUST00000358931.1 ENSMUSG00000140313 ENSMUST00000358931.1 ENSMUSG00000140313 (from geneSymbol) uc337tpp.1 uc337tpp.1 
ENSMUST00000358932.1 ENSMUSG00000140314 ENSMUST00000358932.1 ENSMUSG00000140314 (from geneSymbol) AK165607 uc337tpq.1 uc337tpq.1 
ENSMUST00000359000.1 Gm29152 ENSMUST00000359000.1 Gm29152 (from geneSymbol) uc337tsg.1 uc337tsg.1 
ENSMUST00000359009.1 ENSMUSG00000140315 ENSMUST00000359009.1 ENSMUSG00000140315 (from geneSymbol) uc337tsp.1 uc337tsp.1 
ENSMUST00000359018.1 ENSMUSG00000140316 ENSMUST00000359018.1 ENSMUSG00000140316 (from geneSymbol) uc337tsy.1 uc337tsy.1 
ENSMUST00000359019.1 ENSMUSG00000140317 ENSMUST00000359019.1 ENSMUSG00000140317 (from geneSymbol) uc337tsz.1 uc337tsz.1 
ENSMUST00000359026.1 ENSMUSG00000140318 ENSMUST00000359026.1 ENSMUSG00000140318 (from geneSymbol) uc337ttf.1 uc337ttf.1 
ENSMUST00000359028.1 ENSMUSG00000140319 ENSMUST00000359028.1 ENSMUSG00000140319 (from geneSymbol) uc337tth.1 uc337tth.1 
ENSMUST00000359032.1 ENSMUSG00000140320 ENSMUST00000359032.1 ENSMUSG00000140320 (from geneSymbol) uc337ttl.1 uc337ttl.1 
ENSMUST00000359034.1 ENSMUSG00000140321 ENSMUST00000359034.1 ENSMUSG00000140321 (from geneSymbol) uc337ttn.1 uc337ttn.1 
ENSMUST00000359038.1 ENSMUSG00000140322 ENSMUST00000359038.1 ENSMUSG00000140322 (from geneSymbol) uc337ttr.1 uc337ttr.1 
ENSMUST00000359039.1 4930414F18Rik ENSMUST00000359039.1 4930414F18Rik (from geneSymbol) AK019576 uc337tts.1 uc337tts.1 
ENSMUST00000359061.1 Grip1os2 ENSMUST00000359061.1 Grip1os2 (from geneSymbol) AK016220 uc337tum.1 uc337tum.1 
ENSMUST00000359067.1 ENSMUSG00000140323 ENSMUST00000359067.1 ENSMUSG00000140323 (from geneSymbol) uc337tus.1 uc337tus.1 
ENSMUST00000359069.1 ENSMUSG00000140324 ENSMUST00000359069.1 ENSMUSG00000140324 (from geneSymbol) uc337tuu.1 uc337tuu.1 
ENSMUST00000359071.1 ENSMUSG00000140325 ENSMUST00000359071.1 ENSMUSG00000140325 (from geneSymbol) uc337tuw.1 uc337tuw.1 
ENSMUST00000359072.1 ENSMUSG00000140326 ENSMUST00000359072.1 ENSMUSG00000140326 (from geneSymbol) uc337tux.1 uc337tux.1 
ENSMUST00000359074.1 ENSMUSG00000140327 ENSMUST00000359074.1 ENSMUSG00000140327 (from geneSymbol) BC100414 uc337tuz.1 uc337tuz.1 
ENSMUST00000359075.1 ENSMUSG00000140328 ENSMUST00000359075.1 ENSMUSG00000140328 (from geneSymbol) uc337tva.1 uc337tva.1 
ENSMUST00000359078.1 ENSMUSG00000140329 ENSMUST00000359078.1 ENSMUSG00000140329 (from geneSymbol) uc337tvd.1 uc337tvd.1 
ENSMUST00000359090.1 ENSMUSG00000140330 ENSMUST00000359090.1 ENSMUSG00000140330 (from geneSymbol) uc337tvp.1 uc337tvp.1 
ENSMUST00000359096.1 Gm19439 ENSMUST00000359096.1 Gm19439 (from geneSymbol) uc337tvv.1 uc337tvv.1 
ENSMUST00000359100.1 ENSMUSG00000140332 ENSMUST00000359100.1 ENSMUSG00000140332 (from geneSymbol) uc337tvz.1 uc337tvz.1 
ENSMUST00000359102.1 ENSMUSG00000140333 ENSMUST00000359102.1 ENSMUSG00000140333 (from geneSymbol) uc337twb.1 uc337twb.1 
ENSMUST00000359103.1 ENSMUSG00000140334 ENSMUST00000359103.1 ENSMUSG00000140334 (from geneSymbol) uc337twc.1 uc337twc.1 
ENSMUST00000359104.1 ENSMUSG00000140335 ENSMUST00000359104.1 ENSMUSG00000140335 (from geneSymbol) uc337twd.1 uc337twd.1 
ENSMUST00000359106.1 1700029M03Rik ENSMUST00000359106.1 1700029M03Rik (from geneSymbol) AK076808 uc337twf.1 uc337twf.1 
ENSMUST00000359117.1 ENSMUSG00000140336 ENSMUST00000359117.1 ENSMUSG00000140336 (from geneSymbol) AK142117 uc337twq.1 uc337twq.1 
ENSMUST00000359120.1 ENSMUSG00000140337 ENSMUST00000359120.1 ENSMUSG00000140337 (from geneSymbol) uc337twt.1 uc337twt.1 
ENSMUST00000359122.1 ENSMUSG00000140338 ENSMUST00000359122.1 ENSMUSG00000140338 (from geneSymbol) uc337twv.1 uc337twv.1 
ENSMUST00000359123.1 ENSMUSG00000140339 ENSMUST00000359123.1 ENSMUSG00000140339 (from geneSymbol) uc337tww.1 uc337tww.1 
ENSMUST00000359127.1 ENSMUSG00000140340 ENSMUST00000359127.1 ENSMUSG00000140340 (from geneSymbol) uc337txa.1 uc337txa.1 
ENSMUST00000359134.1 ENSMUSG00000140341 ENSMUST00000359134.1 ENSMUSG00000140341 (from geneSymbol) uc337txh.1 uc337txh.1 
ENSMUST00000359138.1 ENSMUSG00000140342 ENSMUST00000359138.1 ENSMUSG00000140342 (from geneSymbol) uc337txl.1 uc337txl.1 
ENSMUST00000359139.1 ENSMUSG00000140343 ENSMUST00000359139.1 ENSMUSG00000140343 (from geneSymbol) uc337txm.1 uc337txm.1 
ENSMUST00000359143.1 ENSMUSG00000140344 ENSMUST00000359143.1 ENSMUSG00000140344 (from geneSymbol) uc337txq.1 uc337txq.1 
ENSMUST00000359144.1 ENSMUSG00000140345 ENSMUST00000359144.1 ENSMUSG00000140345 (from geneSymbol) uc337txr.1 uc337txr.1 
ENSMUST00000359145.1 ENSMUSG00000140346 ENSMUST00000359145.1 ENSMUSG00000140346 (from geneSymbol) uc337txs.1 uc337txs.1 
ENSMUST00000359154.1 ENSMUSG00000140347 ENSMUST00000359154.1 ENSMUSG00000140347 (from geneSymbol) uc337tyb.1 uc337tyb.1 
ENSMUST00000359155.1 ENSMUSG00000140348 ENSMUST00000359155.1 ENSMUSG00000140348 (from geneSymbol) uc337tyc.1 uc337tyc.1 
ENSMUST00000359157.1 ENSMUSG00000140349 ENSMUST00000359157.1 ENSMUSG00000140349 (from geneSymbol) uc337tye.1 uc337tye.1 
ENSMUST00000359158.1 ENSMUSG00000140350 ENSMUST00000359158.1 ENSMUSG00000140350 (from geneSymbol) BC055874 uc337tyf.1 uc337tyf.1 
ENSMUST00000359159.1 ENSMUSG00000140351 ENSMUST00000359159.1 ENSMUSG00000140351 (from geneSymbol) uc337tyg.1 uc337tyg.1 
ENSMUST00000359160.1 ENSMUSG00000140352 ENSMUST00000359160.1 ENSMUSG00000140352 (from geneSymbol) uc337tyh.1 uc337tyh.1 
ENSMUST00000359162.1 ENSMUSG00000140354 ENSMUST00000359162.1 ENSMUSG00000140354 (from geneSymbol) uc337tyi.1 uc337tyi.1 
ENSMUST00000359167.1 ENSMUSG00000140355 ENSMUST00000359167.1 ENSMUSG00000140355 (from geneSymbol) uc337tyn.1 uc337tyn.1 
ENSMUST00000359168.1 Gm34684 ENSMUST00000359168.1 Gm34684 (from geneSymbol) uc337tyo.1 uc337tyo.1 
ENSMUST00000359171.1 ENSMUSG00000140356 ENSMUST00000359171.1 ENSMUSG00000140356 (from geneSymbol) uc337tyr.1 uc337tyr.1 
ENSMUST00000359175.1 ENSMUSG00000140357 ENSMUST00000359175.1 ENSMUSG00000140357 (from geneSymbol) uc337tyv.1 uc337tyv.1 
ENSMUST00000359179.1 Nell1os ENSMUST00000359179.1 Nell1os (from geneSymbol) AK006968 uc337tyz.1 uc337tyz.1 
ENSMUST00000359186.1 ENSMUSG00000140358 ENSMUST00000359186.1 ENSMUSG00000140358 (from geneSymbol) uc337tzg.1 uc337tzg.1 
ENSMUST00000359188.1 ENSMUSG00000140359 ENSMUST00000359188.1 ENSMUSG00000140359 (from geneSymbol) uc337tzi.1 uc337tzi.1 
ENSMUST00000359192.1 ENSMUSG00000140360 ENSMUST00000359192.1 ENSMUSG00000140360 (from geneSymbol) uc337tzm.1 uc337tzm.1 
ENSMUST00000359199.1 ENSMUSG00000140361 ENSMUST00000359199.1 ENSMUSG00000140361 (from geneSymbol) uc337tzt.1 uc337tzt.1 
ENSMUST00000359201.1 ENSMUSG00000140362 ENSMUST00000359201.1 ENSMUSG00000140362 (from geneSymbol) uc337tzv.1 uc337tzv.1 
ENSMUST00000359203.1 ENSMUSG00000140363 ENSMUST00000359203.1 ENSMUSG00000140363 (from geneSymbol) uc337tzx.1 uc337tzx.1 
ENSMUST00000359207.1 ENSMUSG00000140364 ENSMUST00000359207.1 ENSMUSG00000140364 (from geneSymbol) LF201701 uc337uab.1 uc337uab.1 
ENSMUST00000359214.1 1700003L19Rik ENSMUST00000359214.1 1700003L19Rik (from geneSymbol) AK005649 uc337uai.1 uc337uai.1 
ENSMUST00000359233.1 Gm11337 ENSMUST00000359233.1 Gm11337 (from geneSymbol) uc337ubb.1 uc337ubb.1 
ENSMUST00000359235.1 ENSMUSG00000140365 ENSMUST00000359235.1 ENSMUSG00000140365 (from geneSymbol) uc337ubd.1 uc337ubd.1 
ENSMUST00000359237.1 ENSMUSG00000140366 ENSMUST00000359237.1 ENSMUSG00000140366 (from geneSymbol) uc337ubf.1 uc337ubf.1 
ENSMUST00000359238.1 ENSMUSG00000140367 ENSMUST00000359238.1 ENSMUSG00000140367 (from geneSymbol) uc337ubg.1 uc337ubg.1 
ENSMUST00000359239.1 ENSMUSG00000140368 ENSMUST00000359239.1 ENSMUSG00000140368 (from geneSymbol) uc337ubh.1 uc337ubh.1 
ENSMUST00000359240.1 ENSMUSG00000140369 ENSMUST00000359240.1 ENSMUSG00000140369 (from geneSymbol) uc337ubi.1 uc337ubi.1 
ENSMUST00000359242.1 ENSMUSG00000140370 ENSMUST00000359242.1 ENSMUSG00000140370 (from geneSymbol) uc337ubk.1 uc337ubk.1 
ENSMUST00000359245.1 ENSMUSG00000140371 ENSMUST00000359245.1 ENSMUSG00000140371 (from geneSymbol) uc337ubn.1 uc337ubn.1 
ENSMUST00000359246.1 ENSMUSG00000140372 ENSMUST00000359246.1 ENSMUSG00000140372 (from geneSymbol) uc337ubo.1 uc337ubo.1 
ENSMUST00000359248.1 ENSMUSG00000140373 ENSMUST00000359248.1 ENSMUSG00000140373 (from geneSymbol) uc337ubq.1 uc337ubq.1 
ENSMUST00000359249.1 Gm48954 ENSMUST00000359249.1 Gm48954 (from geneSymbol) uc337ubr.1 uc337ubr.1 
ENSMUST00000359264.1 ENSMUSG00000140374 ENSMUST00000359264.1 ENSMUSG00000140374 (from geneSymbol) AK076714 uc337ucg.1 uc337ucg.1 
ENSMUST00000359272.1 ENSMUSG00000140375 ENSMUST00000359272.1 ENSMUSG00000140375 (from geneSymbol) uc337uco.1 uc337uco.1 
ENSMUST00000359274.1 ENSMUSG00000140376 ENSMUST00000359274.1 ENSMUSG00000140376 (from geneSymbol) uc337ucq.1 uc337ucq.1 
ENSMUST00000359276.1 Gm41979 ENSMUST00000359276.1 Gm41979 (from geneSymbol) uc337ucs.1 uc337ucs.1 
ENSMUST00000359280.1 ENSMUSG00000140377 ENSMUST00000359280.1 ENSMUSG00000140377 (from geneSymbol) uc337ucw.1 uc337ucw.1 
ENSMUST00000359284.1 Gm11627 ENSMUST00000359284.1 Gm11627 (from geneSymbol) AK144330 uc337uda.1 uc337uda.1 
ENSMUST00000359296.1 ENSMUSG00000140378 ENSMUST00000359296.1 ENSMUSG00000140378 (from geneSymbol) uc337udm.1 uc337udm.1 
ENSMUST00000359297.1 ENSMUSG00000140379 ENSMUST00000359297.1 ENSMUSG00000140379 (from geneSymbol) uc337udn.1 uc337udn.1 
ENSMUST00000359298.1 ENSMUSG00000140380 ENSMUST00000359298.1 ENSMUSG00000140380 (from geneSymbol) uc337udo.1 uc337udo.1 
ENSMUST00000359306.1 ENSMUSG00000140381 ENSMUST00000359306.1 ENSMUSG00000140381 (from geneSymbol) uc337udw.1 uc337udw.1 
ENSMUST00000359337.1 ENSMUSG00000140382 ENSMUST00000359337.1 ENSMUSG00000140382 (from geneSymbol) uc337ufb.1 uc337ufb.1 
ENSMUST00000359338.1 ENSMUSG00000140383 ENSMUST00000359338.1 ENSMUSG00000140383 (from geneSymbol) uc337ufc.1 uc337ufc.1 
ENSMUST00000359339.1 ENSMUSG00000140384 ENSMUST00000359339.1 ENSMUSG00000140384 (from geneSymbol) uc337ufd.1 uc337ufd.1 
ENSMUST00000359340.1 ENSMUSG00000140385 ENSMUST00000359340.1 ENSMUSG00000140385 (from geneSymbol) uc337ufe.1 uc337ufe.1 
ENSMUST00000359342.1 ENSMUSG00000140386 ENSMUST00000359342.1 ENSMUSG00000140386 (from geneSymbol) uc337ufg.1 uc337ufg.1 
ENSMUST00000359345.1 Gm4890 ENSMUST00000359345.1 Gm4890 (from geneSymbol) KY468193 uc337ufj.1 uc337ufj.1 
ENSMUST00000359352.1 ENSMUSG00000140387 ENSMUST00000359352.1 ENSMUSG00000140387 (from geneSymbol) uc337ufq.1 uc337ufq.1 
ENSMUST00000359353.1 ENSMUSG00000140388 ENSMUST00000359353.1 ENSMUSG00000140388 (from geneSymbol) AK007300 uc337ufr.1 uc337ufr.1 
ENSMUST00000359354.1 ENSMUSG00000140389 ENSMUST00000359354.1 ENSMUSG00000140389 (from geneSymbol) uc337ufs.1 uc337ufs.1 
ENSMUST00000359355.1 ENSMUSG00000140390 ENSMUST00000359355.1 ENSMUSG00000140390 (from geneSymbol) uc337uft.1 uc337uft.1 
ENSMUST00000359359.1 ENSMUSG00000140391 ENSMUST00000359359.1 ENSMUSG00000140391 (from geneSymbol) uc337ufx.1 uc337ufx.1 
ENSMUST00000359360.1 ENSMUSG00000140392 ENSMUST00000359360.1 ENSMUSG00000140392 (from geneSymbol) uc337ufy.1 uc337ufy.1 
ENSMUST00000359369.1 ENSMUSG00000140393 ENSMUST00000359369.1 ENSMUSG00000140393 (from geneSymbol) uc337ugh.1 uc337ugh.1 
ENSMUST00000359370.1 ENSMUSG00000140394 ENSMUST00000359370.1 ENSMUSG00000140394 (from geneSymbol) uc337ugi.1 uc337ugi.1 
ENSMUST00000359371.1 ENSMUSG00000140395 ENSMUST00000359371.1 ENSMUSG00000140395 (from geneSymbol) uc337ugj.1 uc337ugj.1 
ENSMUST00000359372.1 ENSMUSG00000140396 ENSMUST00000359372.1 ENSMUSG00000140396 (from geneSymbol) uc337ugk.1 uc337ugk.1 
ENSMUST00000359373.1 ENSMUSG00000140397 ENSMUST00000359373.1 ENSMUSG00000140397 (from geneSymbol) uc337ugl.1 uc337ugl.1 
ENSMUST00000359383.1 ENSMUSG00000140398 ENSMUST00000359383.1 ENSMUSG00000140398 (from geneSymbol) uc337ugv.1 uc337ugv.1 
ENSMUST00000359387.1 ENSMUSG00000140399 ENSMUST00000359387.1 ENSMUSG00000140399 (from geneSymbol) uc337ugz.1 uc337ugz.1 
ENSMUST00000359394.1 ENSMUSG00000140400 ENSMUST00000359394.1 ENSMUSG00000140400 (from geneSymbol) uc337uhg.1 uc337uhg.1 
ENSMUST00000359398.1 ENSMUSG00000140401 ENSMUST00000359398.1 ENSMUSG00000140401 (from geneSymbol) uc337uhk.1 uc337uhk.1 
ENSMUST00000359399.1 ENSMUSG00000140402 ENSMUST00000359399.1 ENSMUSG00000140402 (from geneSymbol) uc337uhl.1 uc337uhl.1 
ENSMUST00000359403.1 ENSMUSG00000140403 ENSMUST00000359403.1 ENSMUSG00000140403 (from geneSymbol) uc337uhp.1 uc337uhp.1 
ENSMUST00000359413.1 ENSMUSG00000140404 ENSMUST00000359413.1 ENSMUSG00000140404 (from geneSymbol) uc337uhz.1 uc337uhz.1 
ENSMUST00000359414.1 ENSMUSG00000140405 ENSMUST00000359414.1 ENSMUSG00000140405 (from geneSymbol) uc337uia.1 uc337uia.1 
ENSMUST00000359416.1 ENSMUSG00000140406 ENSMUST00000359416.1 ENSMUSG00000140406 (from geneSymbol) uc337uic.1 uc337uic.1 
ENSMUST00000359417.1 ENSMUSG00000140407 ENSMUST00000359417.1 ENSMUSG00000140407 (from geneSymbol) uc337uid.1 uc337uid.1 
ENSMUST00000359423.1 ENSMUSG00000140408 ENSMUST00000359423.1 ENSMUSG00000140408 (from geneSymbol) uc337uij.1 uc337uij.1 
ENSMUST00000359426.1 ENSMUSG00000140409 ENSMUST00000359426.1 ENSMUSG00000140409 (from geneSymbol) uc337uim.1 uc337uim.1 
ENSMUST00000359427.1 ENSMUSG00000140410 ENSMUST00000359427.1 ENSMUSG00000140410 (from geneSymbol) uc337uin.1 uc337uin.1 
ENSMUST00000359428.1 ENSMUSG00000140411 ENSMUST00000359428.1 ENSMUSG00000140411 (from geneSymbol) uc337uio.1 uc337uio.1 
ENSMUST00000359430.1 ENSMUSG00000140412 ENSMUST00000359430.1 ENSMUSG00000140412 (from geneSymbol) uc337uiq.1 uc337uiq.1 
ENSMUST00000359431.1 ENSMUSG00000140413 ENSMUST00000359431.1 ENSMUSG00000140413 (from geneSymbol) uc337uir.1 uc337uir.1 
ENSMUST00000359433.1 ENSMUSG00000140414 ENSMUST00000359433.1 ENSMUSG00000140414 (from geneSymbol) uc337uit.1 uc337uit.1 
ENSMUST00000359435.1 ENSMUSG00000140415 ENSMUST00000359435.1 ENSMUSG00000140415 (from geneSymbol) uc337uiv.1 uc337uiv.1 
ENSMUST00000359436.1 ENSMUSG00000140416 ENSMUST00000359436.1 ENSMUSG00000140416 (from geneSymbol) uc337uiw.1 uc337uiw.1 
ENSMUST00000359438.1 ENSMUSG00000140417 ENSMUST00000359438.1 ENSMUSG00000140417 (from geneSymbol) uc337uiy.1 uc337uiy.1 
ENSMUST00000359440.1 ENSMUSG00000140418 ENSMUST00000359440.1 ENSMUSG00000140418 (from geneSymbol) uc337uja.1 uc337uja.1 
ENSMUST00000359441.1 ENSMUSG00000140419 ENSMUST00000359441.1 ENSMUSG00000140419 (from geneSymbol) uc337ujb.1 uc337ujb.1 
ENSMUST00000359445.1 ENSMUSG00000140420 ENSMUST00000359445.1 ENSMUSG00000140420 (from geneSymbol) uc337ujf.1 uc337ujf.1 
ENSMUST00000359462.1 ENSMUSG00000140421 ENSMUST00000359462.1 ENSMUSG00000140421 (from geneSymbol) uc337ujw.1 uc337ujw.1 
ENSMUST00000359464.1 ENSMUSG00000140422 ENSMUST00000359464.1 ENSMUSG00000140422 (from geneSymbol) uc337ujy.1 uc337ujy.1 
ENSMUST00000359465.1 ENSMUSG00000140423 ENSMUST00000359465.1 ENSMUSG00000140423 (from geneSymbol) uc337ujz.1 uc337ujz.1 
ENSMUST00000359466.1 ENSMUSG00000140424 ENSMUST00000359466.1 ENSMUSG00000140424 (from geneSymbol) uc337uka.1 uc337uka.1 
ENSMUST00000359468.1 ENSMUSG00000140425 ENSMUST00000359468.1 ENSMUSG00000140425 (from geneSymbol) uc337ukc.1 uc337ukc.1 
ENSMUST00000359470.1 ENSMUSG00000140426 ENSMUST00000359470.1 ENSMUSG00000140426 (from geneSymbol) uc337uke.1 uc337uke.1 
ENSMUST00000359472.1 ENSMUSG00000140427 ENSMUST00000359472.1 ENSMUSG00000140427 (from geneSymbol) uc337ukg.1 uc337ukg.1 
ENSMUST00000359478.1 ENSMUSG00000140428 ENSMUST00000359478.1 ENSMUSG00000140428 (from geneSymbol) uc337ukm.1 uc337ukm.1 
ENSMUST00000359481.1 ENSMUSG00000140429 ENSMUST00000359481.1 ENSMUSG00000140429 (from geneSymbol) uc337ukp.1 uc337ukp.1 
ENSMUST00000359482.1 ENSMUSG00000140430 ENSMUST00000359482.1 ENSMUSG00000140430 (from geneSymbol) uc337ukq.1 uc337ukq.1 
ENSMUST00000359483.1 B230312C02Rik ENSMUST00000359483.1 B230312C02Rik (from geneSymbol) AK045814 uc337ukr.1 uc337ukr.1 
ENSMUST00000359504.1 ENSMUSG00000140431 ENSMUST00000359504.1 ENSMUSG00000140431 (from geneSymbol) uc337ulm.1 uc337ulm.1 
ENSMUST00000359512.1 ENSMUSG00000140432 ENSMUST00000359512.1 ENSMUSG00000140432 (from geneSymbol) uc337ulu.1 uc337ulu.1 
ENSMUST00000359513.1 ENSMUSG00000140433 ENSMUST00000359513.1 ENSMUSG00000140433 (from geneSymbol) uc337ulv.1 uc337ulv.1 
ENSMUST00000359524.1 Gm26822 ENSMUST00000359524.1 Gm26822 (from geneSymbol) AK079491 uc337umg.1 uc337umg.1 
ENSMUST00000359525.1 ENSMUSG00000140434 ENSMUST00000359525.1 ENSMUSG00000140434 (from geneSymbol) uc337umh.1 uc337umh.1 
ENSMUST00000359526.1 ENSMUSG00000140435 ENSMUST00000359526.1 ENSMUSG00000140435 (from geneSymbol) uc337umi.1 uc337umi.1 
ENSMUST00000359529.1 Gm13536 ENSMUST00000359529.1 Gm13536 (from geneSymbol) uc337uml.1 uc337uml.1 
ENSMUST00000359530.1 ENSMUSG00000140436 ENSMUST00000359530.1 ENSMUSG00000140436 (from geneSymbol) uc337umm.1 uc337umm.1 
ENSMUST00000359531.1 ENSMUSG00000140437 ENSMUST00000359531.1 ENSMUSG00000140437 (from geneSymbol) uc337umn.1 uc337umn.1 
ENSMUST00000359540.1 ENSMUSG00000140438 ENSMUST00000359540.1 ENSMUSG00000140438 (from geneSymbol) uc337umw.1 uc337umw.1 
ENSMUST00000359550.1 ENSMUSG00000140439 ENSMUST00000359550.1 ENSMUSG00000140439 (from geneSymbol) uc337ung.1 uc337ung.1 
ENSMUST00000359555.1 Gm26708 ENSMUST00000359555.1 Gm26708 (from geneSymbol) AK132723 uc337unl.1 uc337unl.1 
ENSMUST00000359580.1 ENSMUSG00000140440 ENSMUST00000359580.1 ENSMUSG00000140440 (from geneSymbol) uc337uok.1 uc337uok.1 
ENSMUST00000359583.1 ENSMUSG00000140441 ENSMUST00000359583.1 ENSMUSG00000140441 (from geneSymbol) uc337uon.1 uc337uon.1 
ENSMUST00000359586.1 ENSMUSG00000140442 ENSMUST00000359586.1 ENSMUSG00000140442 (from geneSymbol) uc337uoq.1 uc337uoq.1 
ENSMUST00000359587.1 ENSMUSG00000140443 ENSMUST00000359587.1 ENSMUSG00000140443 (from geneSymbol) uc337uor.1 uc337uor.1 
ENSMUST00000359588.1 ENSMUSG00000140444 ENSMUST00000359588.1 ENSMUSG00000140444 (from geneSymbol) uc337uos.1 uc337uos.1 
ENSMUST00000359590.1 ENSMUSG00000140445 ENSMUST00000359590.1 ENSMUSG00000140445 (from geneSymbol) uc337uou.1 uc337uou.1 
ENSMUST00000359602.1 ENSMUSG00000140446 ENSMUST00000359602.1 ENSMUSG00000140446 (from geneSymbol) uc337upg.1 uc337upg.1 
ENSMUST00000359603.1 ENSMUSG00000140447 ENSMUST00000359603.1 ENSMUSG00000140447 (from geneSymbol) uc337uph.1 uc337uph.1 
ENSMUST00000359604.1 Gm13778 ENSMUST00000359604.1 Gm13778 (from geneSymbol) AK020549 uc337upi.1 uc337upi.1 
ENSMUST00000359614.1 Gm29823 ENSMUST00000359614.1 Gm29823 (from geneSymbol) AK076959 uc337ups.1 uc337ups.1 
ENSMUST00000359622.1 ENSMUSG00000140448 ENSMUST00000359622.1 ENSMUSG00000140448 (from geneSymbol) uc337uqa.1 uc337uqa.1 
ENSMUST00000359623.1 ENSMUSG00000140449 ENSMUST00000359623.1 ENSMUSG00000140449 (from geneSymbol) uc337uqb.1 uc337uqb.1 
ENSMUST00000359624.1 ENSMUSG00000140450 ENSMUST00000359624.1 ENSMUSG00000140450 (from geneSymbol) uc337uqc.1 uc337uqc.1 
ENSMUST00000359637.1 ENSMUSG00000140451 ENSMUST00000359637.1 ENSMUSG00000140451 (from geneSymbol) uc337uqp.1 uc337uqp.1 
ENSMUST00000359646.1 ENSMUSG00000140452 ENSMUST00000359646.1 ENSMUSG00000140452 (from geneSymbol) uc337uqy.1 uc337uqy.1 
ENSMUST00000359647.1 ENSMUSG00000140453 ENSMUST00000359647.1 ENSMUSG00000140453 (from geneSymbol) uc337uqz.1 uc337uqz.1 
ENSMUST00000359648.1 ENSMUSG00000140454 ENSMUST00000359648.1 ENSMUSG00000140454 (from geneSymbol) uc337ura.1 uc337ura.1 
ENSMUST00000359650.1 ENSMUSG00000140455 ENSMUST00000359650.1 ENSMUSG00000140455 (from geneSymbol) uc337urc.1 uc337urc.1 
ENSMUST00000359653.1 ENSMUSG00000140456 ENSMUST00000359653.1 ENSMUSG00000140456 (from geneSymbol) uc337urf.1 uc337urf.1 
ENSMUST00000359655.1 ENSMUSG00000140457 ENSMUST00000359655.1 ENSMUSG00000140457 (from geneSymbol) uc337urh.1 uc337urh.1 
ENSMUST00000359659.1 ENSMUSG00000140458 ENSMUST00000359659.1 ENSMUSG00000140458 (from geneSymbol) uc337url.1 uc337url.1 
ENSMUST00000359660.1 ENSMUSG00000140459 ENSMUST00000359660.1 ENSMUSG00000140459 (from geneSymbol) uc337urm.1 uc337urm.1 
ENSMUST00000359661.1 ENSMUSG00000140460 ENSMUST00000359661.1 ENSMUSG00000140460 (from geneSymbol) uc337urn.1 uc337urn.1 
ENSMUST00000359662.1 ENSMUSG00000140461 ENSMUST00000359662.1 ENSMUSG00000140461 (from geneSymbol) uc337uro.1 uc337uro.1 
ENSMUST00000359663.1 ENSMUSG00000140462 ENSMUST00000359663.1 ENSMUSG00000140462 (from geneSymbol) uc337urp.1 uc337urp.1 
ENSMUST00000359664.1 ENSMUSG00000140463 ENSMUST00000359664.1 ENSMUSG00000140463 (from geneSymbol) uc337urq.1 uc337urq.1 
ENSMUST00000359671.1 ENSMUSG00000140464 ENSMUST00000359671.1 ENSMUSG00000140464 (from geneSymbol) uc337urx.1 uc337urx.1 
ENSMUST00000359674.1 ENSMUSG00000140465 ENSMUST00000359674.1 ENSMUSG00000140465 (from geneSymbol) AK140896 uc337usa.1 uc337usa.1 
ENSMUST00000359679.1 ENSMUSG00000140466 ENSMUST00000359679.1 ENSMUSG00000140466 (from geneSymbol) uc337usf.1 uc337usf.1 
ENSMUST00000359688.1 ENSMUSG00000140467 ENSMUST00000359688.1 ENSMUSG00000140467 (from geneSymbol) uc337uso.1 uc337uso.1 
ENSMUST00000359689.1 ENSMUSG00000140468 ENSMUST00000359689.1 ENSMUSG00000140468 (from geneSymbol) uc337usp.1 uc337usp.1 
ENSMUST00000359690.1 Gm57100 ENSMUST00000359690.1 Gm57100 (from geneSymbol) uc337usq.1 uc337usq.1 
ENSMUST00000359691.1 ENSMUSG00000140469 ENSMUST00000359691.1 ENSMUSG00000140469 (from geneSymbol) uc337usr.1 uc337usr.1 
ENSMUST00000359692.1 Gm56584 ENSMUST00000359692.1 Gm56584 (from geneSymbol) uc337uss.1 uc337uss.1 
ENSMUST00000359694.1 ENSMUSG00000140470 ENSMUST00000359694.1 ENSMUSG00000140470 (from geneSymbol) uc337usu.1 uc337usu.1 
ENSMUST00000359696.1 ENSMUSG00000140472 ENSMUST00000359696.1 ENSMUSG00000140472 (from geneSymbol) uc337usv.1 uc337usv.1 
ENSMUST00000359697.1 ENSMUSG00000140473 ENSMUST00000359697.1 ENSMUSG00000140473 (from geneSymbol) uc337usw.1 uc337usw.1 
ENSMUST00000359704.1 ENSMUSG00000140474 ENSMUST00000359704.1 ENSMUSG00000140474 (from geneSymbol) uc337utd.1 uc337utd.1 
ENSMUST00000359705.1 ENSMUSG00000140475 ENSMUST00000359705.1 ENSMUSG00000140475 (from geneSymbol) uc337ute.1 uc337ute.1 
ENSMUST00000359711.1 ENSMUSG00000140476 ENSMUST00000359711.1 ENSMUSG00000140476 (from geneSymbol) uc337utk.1 uc337utk.1 
ENSMUST00000359713.1 ENSMUSG00000140478 ENSMUST00000359713.1 ENSMUSG00000140478 (from geneSymbol) uc337utl.1 uc337utl.1 
ENSMUST00000359742.1 ENSMUSG00000140479 ENSMUST00000359742.1 ENSMUSG00000140479 (from geneSymbol) uc337uuo.1 uc337uuo.1 
ENSMUST00000359750.1 ENSMUSG00000140480 ENSMUST00000359750.1 ENSMUSG00000140480 (from geneSymbol) uc337uuw.1 uc337uuw.1 
ENSMUST00000359751.1 1700003O11Rik ENSMUST00000359751.1 1700003O11Rik (from geneSymbol) AK005654 uc337uux.1 uc337uux.1 
ENSMUST00000359752.1 ENSMUSG00000140481 ENSMUST00000359752.1 ENSMUSG00000140481 (from geneSymbol) uc337uuy.1 uc337uuy.1 
ENSMUST00000359753.1 ENSMUSG00000140482 ENSMUST00000359753.1 ENSMUSG00000140482 (from geneSymbol) uc337uuz.1 uc337uuz.1 
ENSMUST00000359756.1 ENSMUSG00000140483 ENSMUST00000359756.1 ENSMUSG00000140483 (from geneSymbol) uc337uvc.1 uc337uvc.1 
ENSMUST00000359757.1 4930401O12Rik ENSMUST00000359757.1 4930401O12Rik (from geneSymbol) AK015040 uc337uvd.1 uc337uvd.1 
ENSMUST00000359759.1 ENSMUSG00000140484 ENSMUST00000359759.1 ENSMUSG00000140484 (from geneSymbol) uc337uvf.1 uc337uvf.1 
ENSMUST00000359761.1 Gm49442 ENSMUST00000359761.1 Gm49442 (from geneSymbol) uc337uvg.1 uc337uvg.1 
ENSMUST00000359762.1 ENSMUSG00000140486 ENSMUST00000359762.1 ENSMUSG00000140486 (from geneSymbol) uc337uvh.1 uc337uvh.1 
ENSMUST00000359764.1 ENSMUSG00000140487 ENSMUST00000359764.1 ENSMUSG00000140487 (from geneSymbol) uc337uvj.1 uc337uvj.1 
ENSMUST00000359773.1 4933434P08Rik ENSMUST00000359773.1 4933434P08Rik (from geneSymbol) AK017062 uc337uvs.1 uc337uvs.1 
ENSMUST00000359787.1 ENSMUSG00000140488 ENSMUST00000359787.1 ENSMUSG00000140488 (from geneSymbol) uc337uwg.1 uc337uwg.1 
ENSMUST00000359795.1 ENSMUSG00000140489 ENSMUST00000359795.1 ENSMUSG00000140489 (from geneSymbol) uc337uwo.1 uc337uwo.1 
ENSMUST00000359819.1 ENSMUSG00000140490 ENSMUST00000359819.1 ENSMUSG00000140490 (from geneSymbol) uc337uxl.1 uc337uxl.1 
ENSMUST00000359821.1 ENSMUSG00000140491 ENSMUST00000359821.1 predicted gene, 52688 (from RefSeq NR_168681.1) NR_168681 uc337uxn.1 uc337uxn.1 
ENSMUST00000359822.1 Gm30873 ENSMUST00000359822.1 Gm30873 (from geneSymbol) AK035526 uc337uxo.1 uc337uxo.1 
ENSMUST00000359823.1 ENSMUSG00000140492 ENSMUST00000359823.1 ENSMUSG00000140492 (from geneSymbol) uc337uxp.1 uc337uxp.1 
ENSMUST00000359824.1 ENSMUSG00000140493 ENSMUST00000359824.1 ENSMUSG00000140493 (from geneSymbol) uc337uxq.1 uc337uxq.1 
ENSMUST00000359826.1 ENSMUSG00000140494 ENSMUST00000359826.1 ENSMUSG00000140494 (from geneSymbol) uc337uxs.1 uc337uxs.1 
ENSMUST00000359829.1 ENSMUSG00000140495 ENSMUST00000359829.1 ENSMUSG00000140495 (from geneSymbol) uc337uxv.1 uc337uxv.1 
ENSMUST00000359831.1 ENSMUSG00000140496 ENSMUST00000359831.1 ENSMUSG00000140496 (from geneSymbol) uc337uxx.1 uc337uxx.1 
ENSMUST00000359832.1 ENSMUSG00000140497 ENSMUST00000359832.1 ENSMUSG00000140497 (from geneSymbol) uc337uxy.1 uc337uxy.1 
ENSMUST00000359833.1 ENSMUSG00000140498 ENSMUST00000359833.1 ENSMUSG00000140498 (from geneSymbol) uc337uxz.1 uc337uxz.1 
ENSMUST00000359834.1 ENSMUSG00000140499 ENSMUST00000359834.1 ENSMUSG00000140499 (from geneSymbol) uc337uya.1 uc337uya.1 
ENSMUST00000359835.1 ENSMUSG00000140500 ENSMUST00000359835.1 ENSMUSG00000140500 (from geneSymbol) uc337uyb.1 uc337uyb.1 
ENSMUST00000359841.1 ENSMUSG00000140501 ENSMUST00000359841.1 ENSMUSG00000140501 (from geneSymbol) BC032978 uc337uyh.1 uc337uyh.1 
ENSMUST00000359845.1 ENSMUSG00000140502 ENSMUST00000359845.1 ENSMUSG00000140502 (from geneSymbol) uc337uyl.1 uc337uyl.1 
ENSMUST00000359848.1 ENSMUSG00000140503 ENSMUST00000359848.1 ENSMUSG00000140503 (from geneSymbol) uc337uyo.1 uc337uyo.1 
ENSMUST00000359850.1 Gm57424 ENSMUST00000359850.1 Gm57424 (from geneSymbol) uc337uyq.1 uc337uyq.1 
ENSMUST00000359864.1 ENSMUSG00000140504 ENSMUST00000359864.1 ENSMUSG00000140504 (from geneSymbol) BC048761 uc337uze.1 uc337uze.1 
ENSMUST00000359875.1 ENSMUSG00000140505 ENSMUST00000359875.1 ENSMUSG00000140505 (from geneSymbol) BC048636 uc337uzp.1 uc337uzp.1 
ENSMUST00000359877.1 ENSMUSG00000140506 ENSMUST00000359877.1 ENSMUSG00000140506 (from geneSymbol) uc337uzr.1 uc337uzr.1 
ENSMUST00000359896.1 ENSMUSG00000140508 ENSMUST00000359896.1 ENSMUSG00000140508 (from geneSymbol) uc337vah.1 uc337vah.1 
ENSMUST00000359911.1 ENSMUSG00000140509 ENSMUST00000359911.1 ENSMUSG00000140509 (from geneSymbol) uc337vaw.1 uc337vaw.1 
ENSMUST00000359927.1 ENSMUSG00000140510 ENSMUST00000359927.1 ENSMUSG00000140510 (from geneSymbol) uc337vbm.1 uc337vbm.1 
ENSMUST00000359929.1 ENSMUSG00000140511 ENSMUST00000359929.1 ENSMUSG00000140511 (from geneSymbol) uc337vbo.1 uc337vbo.1 
ENSMUST00000359931.1 ENSMUSG00000140513 ENSMUST00000359931.1 ENSMUSG00000140513 (from geneSymbol) uc337vbp.1 uc337vbp.1 
ENSMUST00000359932.1 ENSMUSG00000140514 ENSMUST00000359932.1 ENSMUSG00000140514 (from geneSymbol) uc337vbq.1 uc337vbq.1 
ENSMUST00000359934.1 ENSMUSG00000121880 ENSMUST00000359934.1 ENSMUSG00000121880 (from geneSymbol) AK084954 uc337vbs.1 uc337vbs.1 
ENSMUST00000359946.1 ENSMUSG00000140515 ENSMUST00000359946.1 ENSMUSG00000140515 (from geneSymbol) uc337vcd.1 uc337vcd.1 
ENSMUST00000359947.1 ENSMUSG00000140516 ENSMUST00000359947.1 ENSMUSG00000140516 (from geneSymbol) uc337vce.1 uc337vce.1 
ENSMUST00000359950.1 ENSMUSG00000140517 ENSMUST00000359950.1 ENSMUSG00000140517 (from geneSymbol) uc337vch.1 uc337vch.1 
ENSMUST00000359951.1 ENSMUSG00000140518 ENSMUST00000359951.1 ENSMUSG00000140518 (from geneSymbol) uc337vci.1 uc337vci.1 
ENSMUST00000359958.1 ENSMUSG00000140519 ENSMUST00000359958.1 ENSMUSG00000140519 (from geneSymbol) uc337vcp.1 uc337vcp.1 
ENSMUST00000359961.1 ENSMUSG00000140520 ENSMUST00000359961.1 ENSMUSG00000140520 (from geneSymbol) uc337vcs.1 uc337vcs.1 
ENSMUST00000359962.1 ENSMUSG00000140521 ENSMUST00000359962.1 ENSMUSG00000140521 (from geneSymbol) uc337vct.1 uc337vct.1 
ENSMUST00000359964.1 ENSMUSG00000140522 ENSMUST00000359964.1 ENSMUSG00000140522 (from geneSymbol) AK131767 uc337vcv.1 uc337vcv.1 
ENSMUST00000359968.1 ENSMUSG00000140523 ENSMUST00000359968.1 ENSMUSG00000140523 (from geneSymbol) uc337vcz.1 uc337vcz.1 
ENSMUST00000359984.1 ENSMUSG00000140525 ENSMUST00000359984.1 ENSMUSG00000140525 (from geneSymbol) LF203294 uc337vdg.1 uc337vdg.1 
ENSMUST00000359987.1 4933406D12Rik ENSMUST00000359987.1 4933406D12Rik (from geneSymbol) uc337vdi.1 uc337vdi.1 
ENSMUST00000359991.1 ENSMUSG00000140527 ENSMUST00000359991.1 ENSMUSG00000140527 (from geneSymbol) uc337vdm.1 uc337vdm.1 
ENSMUST00000359994.1 ENSMUSG00000140528 ENSMUST00000359994.1 ENSMUSG00000140528 (from geneSymbol) uc337vdp.1 uc337vdp.1 
ENSMUST00000359997.1 ENSMUSG00000140529 ENSMUST00000359997.1 ENSMUSG00000140529 (from geneSymbol) uc337vds.1 uc337vds.1 
ENSMUST00000359999.1 ENSMUSG00000140530 ENSMUST00000359999.1 ENSMUSG00000140530 (from geneSymbol) uc337vdu.1 uc337vdu.1 
ENSMUST00000360000.1 ENSMUSG00000140531 ENSMUST00000360000.1 ENSMUSG00000140531 (from geneSymbol) uc337vdv.1 uc337vdv.1 
ENSMUST00000360001.1 ENSMUSG00000140532 ENSMUST00000360001.1 ENSMUSG00000140532 (from geneSymbol) AK019805 uc337vdw.1 uc337vdw.1 
ENSMUST00000360011.1 ENSMUSG00000140533 ENSMUST00000360011.1 ENSMUSG00000140533 (from geneSymbol) uc337veg.1 uc337veg.1 
ENSMUST00000360013.1 ENSMUSG00000140534 ENSMUST00000360013.1 ENSMUSG00000140534 (from geneSymbol) uc337veh.1 uc337veh.1 
ENSMUST00000360017.1 ENSMUSG00000140535 ENSMUST00000360017.1 ENSMUSG00000140535 (from geneSymbol) uc337vel.1 uc337vel.1 
ENSMUST00000360083.1 4930445N06Rik ENSMUST00000360083.1 RIKEN cDNA 4930445N06 gene (from RefSeq NR_175388.1) NR_175388 uc337vgy.1 uc337vgy.1 
ENSMUST00000360100.1 ENSMUSG00000140536 ENSMUST00000360100.1 ENSMUSG00000140536 (from geneSymbol) uc337vhp.1 uc337vhp.1 
ENSMUST00000360101.1 ENSMUSG00000140537 ENSMUST00000360101.1 ENSMUSG00000140537 (from geneSymbol) uc337vhq.1 uc337vhq.1 
ENSMUST00000360104.1 ENSMUSG00000140538 ENSMUST00000360104.1 ENSMUSG00000140538 (from geneSymbol) uc337vht.1 uc337vht.1 
ENSMUST00000360106.1 ENSMUSG00000140539 ENSMUST00000360106.1 ENSMUSG00000140539 (from geneSymbol) uc337vhv.1 uc337vhv.1 
ENSMUST00000360115.1 ENSMUSG00000140540 ENSMUST00000360115.1 ENSMUSG00000140540 (from geneSymbol) uc337vie.1 uc337vie.1 
ENSMUST00000360116.1 ENSMUSG00000140541 ENSMUST00000360116.1 ENSMUSG00000140541 (from geneSymbol) uc337vif.1 uc337vif.1 
ENSMUST00000360131.1 Gm46652 ENSMUST00000360131.1 Gm46652 (from geneSymbol) uc337viu.1 uc337viu.1 
ENSMUST00000360139.1 ENSMUSG00000140542 ENSMUST00000360139.1 ENSMUSG00000140542 (from geneSymbol) uc337vjc.1 uc337vjc.1 
ENSMUST00000360140.1 Gm57114 ENSMUST00000360140.1 Gm57114 (from geneSymbol) uc337vjd.1 uc337vjd.1 
ENSMUST00000360147.1 ENSMUSG00000140544 ENSMUST00000360147.1 ENSMUSG00000140544 (from geneSymbol) uc337vjk.1 uc337vjk.1 
ENSMUST00000360149.1 ENSMUSG00000140545 ENSMUST00000360149.1 ENSMUSG00000140545 (from geneSymbol) uc337vjm.1 uc337vjm.1 
ENSMUST00000360150.1 ENSMUSG00000140546 ENSMUST00000360150.1 ENSMUSG00000140546 (from geneSymbol) uc337vjn.1 uc337vjn.1 
ENSMUST00000360163.1 8430429K09Rik ENSMUST00000360163.1 8430429K09Rik (from geneSymbol) AK086952 uc337vka.1 uc337vka.1 
ENSMUST00000360179.1 ENSMUSG00000140547 ENSMUST00000360179.1 ENSMUSG00000140547 (from geneSymbol) uc337vkq.1 uc337vkq.1 
ENSMUST00000360193.1 ENSMUSG00000140548 ENSMUST00000360193.1 ENSMUSG00000140548 (from geneSymbol) uc337vle.1 uc337vle.1 
ENSMUST00000360195.1 ENSMUSG00000140549 ENSMUST00000360195.1 ENSMUSG00000140549 (from geneSymbol) uc337vlg.1 uc337vlg.1 
ENSMUST00000360208.1 ENSMUSG00000140550 ENSMUST00000360208.1 ENSMUSG00000140550 (from geneSymbol) uc337vlt.1 uc337vlt.1 
ENSMUST00000360210.1 ENSMUSG00000140551 ENSMUST00000360210.1 ENSMUSG00000140551 (from geneSymbol) uc337vlv.1 uc337vlv.1 
ENSMUST00000360211.1 ENSMUSG00000140552 ENSMUST00000360211.1 ENSMUSG00000140552 (from geneSymbol) uc337vlw.1 uc337vlw.1 
ENSMUST00000360212.1 ENSMUSG00000140553 ENSMUST00000360212.1 ENSMUSG00000140553 (from geneSymbol) uc337vlx.1 uc337vlx.1 
ENSMUST00000360250.1 ENSMUSG00000140554 ENSMUST00000360250.1 ENSMUSG00000140554 (from geneSymbol) LF198756 uc337vnj.1 uc337vnj.1 
ENSMUST00000360251.1 ENSMUSG00000140555 ENSMUST00000360251.1 ENSMUSG00000140555 (from geneSymbol) uc337vnk.1 uc337vnk.1 
ENSMUST00000360253.1 ENSMUSG00000140556 ENSMUST00000360253.1 ENSMUSG00000140556 (from geneSymbol) uc337vnm.1 uc337vnm.1 
ENSMUST00000360254.1 ENSMUSG00000140557 ENSMUST00000360254.1 ENSMUSG00000140557 (from geneSymbol) uc337vnn.1 uc337vnn.1 
ENSMUST00000360255.1 ENSMUSG00000140558 ENSMUST00000360255.1 ENSMUSG00000140558 (from geneSymbol) uc337vno.1 uc337vno.1 
ENSMUST00000360256.1 ENSMUSG00000140559 ENSMUST00000360256.1 ENSMUSG00000140559 (from geneSymbol) uc337vnp.1 uc337vnp.1 
ENSMUST00000360257.1 Gm48724 ENSMUST00000360257.1 Gm48724 (from geneSymbol) uc337vnq.1 uc337vnq.1 
ENSMUST00000360261.1 ENSMUSG00000140560 ENSMUST00000360261.1 ENSMUSG00000140560 (from geneSymbol) uc337vnu.1 uc337vnu.1 
ENSMUST00000360262.1 ENSMUSG00000140561 ENSMUST00000360262.1 ENSMUSG00000140561 (from geneSymbol) uc337vnv.1 uc337vnv.1 
ENSMUST00000360265.1 Gm20470 ENSMUST00000360265.1 Gm20470 (from geneSymbol) AK132823 uc337vny.1 uc337vny.1 
ENSMUST00000360274.1 ENSMUSG00000140562 ENSMUST00000360274.1 ENSMUSG00000140562 (from geneSymbol) uc337vof.1 uc337vof.1 
ENSMUST00000360277.1 Gm32357 ENSMUST00000360277.1 Gm32357 (from geneSymbol) uc337voi.1 uc337voi.1 
ENSMUST00000360293.1 ENSMUSG00000140563 ENSMUST00000360293.1 ENSMUSG00000140563 (from geneSymbol) uc337voy.1 uc337voy.1 
ENSMUST00000360297.1 ENSMUSG00000140564 ENSMUST00000360297.1 ENSMUSG00000140564 (from geneSymbol) uc337vpc.1 uc337vpc.1 
ENSMUST00000360303.1 F630206G17Rik ENSMUST00000360303.1 F630206G17Rik (from geneSymbol) AK154350 uc337vpi.1 uc337vpi.1 
ENSMUST00000360310.1 ENSMUSG00000140565 ENSMUST00000360310.1 ENSMUSG00000140565 (from geneSymbol) uc337vpp.1 uc337vpp.1 
ENSMUST00000360311.1 ENSMUSG00000140566 ENSMUST00000360311.1 ENSMUSG00000140566 (from geneSymbol) uc337vpq.1 uc337vpq.1 
ENSMUST00000360315.1 4930589P08Rik ENSMUST00000360315.1 4930589P08Rik (from geneSymbol) AK016376 uc337vpt.1 uc337vpt.1 
ENSMUST00000360317.1 ENSMUSG00000140567 ENSMUST00000360317.1 ENSMUSG00000140567 (from geneSymbol) uc337vpv.1 uc337vpv.1 
ENSMUST00000360318.1 ENSMUSG00000140568 ENSMUST00000360318.1 ENSMUSG00000140568 (from geneSymbol) AK131796 uc337vpw.1 uc337vpw.1 
ENSMUST00000360320.1 ENSMUSG00000140570 ENSMUST00000360320.1 ENSMUSG00000140570 (from geneSymbol) uc337vpx.1 uc337vpx.1 
ENSMUST00000360326.1 Gm57013 ENSMUST00000360326.1 Gm57013 (from geneSymbol) uc337vqd.1 uc337vqd.1 
ENSMUST00000360340.1 ENSMUSG00000140571 ENSMUST00000360340.1 ENSMUSG00000140571 (from geneSymbol) uc337vqr.1 uc337vqr.1 
ENSMUST00000360342.1 ENSMUSG00000140572 ENSMUST00000360342.1 ENSMUSG00000140572 (from geneSymbol) uc337vqt.1 uc337vqt.1 
ENSMUST00000360343.1 ENSMUSG00000140573 ENSMUST00000360343.1 ENSMUSG00000140573 (from geneSymbol) uc337vqu.1 uc337vqu.1 
ENSMUST00000360344.1 ENSMUSG00000140574 ENSMUST00000360344.1 ENSMUSG00000140574 (from geneSymbol) uc337vqv.1 uc337vqv.1 
ENSMUST00000360349.1 ENSMUSG00000140575 ENSMUST00000360349.1 ENSMUSG00000140575 (from geneSymbol) uc337vra.1 uc337vra.1 
ENSMUST00000360350.1 ENSMUSG00000140576 ENSMUST00000360350.1 ENSMUSG00000140576 (from geneSymbol) uc337vrb.1 uc337vrb.1 
ENSMUST00000360355.1 Gm15489 ENSMUST00000360355.1 Gm15489 (from geneSymbol) AK005910 uc337vrf.1 uc337vrf.1 
ENSMUST00000360364.1 ENSMUSG00000140578 ENSMUST00000360364.1 ENSMUSG00000140578 (from geneSymbol) uc337vro.1 uc337vro.1 
ENSMUST00000360365.1 Gm48730 ENSMUST00000360365.1 Gm48730 (from geneSymbol) uc337vrp.1 uc337vrp.1 
ENSMUST00000360367.1 ENSMUSG00000140579 ENSMUST00000360367.1 ENSMUSG00000140579 (from geneSymbol) uc337vrr.1 uc337vrr.1 
ENSMUST00000360369.1 ENSMUSG00000140580 ENSMUST00000360369.1 ENSMUSG00000140580 (from geneSymbol) uc337vrt.1 uc337vrt.1 
ENSMUST00000360370.1 ENSMUSG00000140581 ENSMUST00000360370.1 ENSMUSG00000140581 (from geneSymbol) uc337vru.1 uc337vru.1 
ENSMUST00000360371.1 ENSMUSG00000140582 ENSMUST00000360371.1 ENSMUSG00000140582 (from geneSymbol) uc337vrv.1 uc337vrv.1 
ENSMUST00000360372.1 ENSMUSG00000140583 ENSMUST00000360372.1 ENSMUSG00000140583 (from geneSymbol) uc337vrw.1 uc337vrw.1 
ENSMUST00000360373.1 ENSMUSG00000140584 ENSMUST00000360373.1 ENSMUSG00000140584 (from geneSymbol) uc337vrx.1 uc337vrx.1 
ENSMUST00000360376.1 ENSMUSG00000140585 ENSMUST00000360376.1 ENSMUSG00000140585 (from geneSymbol) uc337vsa.1 uc337vsa.1 
ENSMUST00000360378.1 ENSMUSG00000140586 ENSMUST00000360378.1 ENSMUSG00000140586 (from geneSymbol) uc337vsc.1 uc337vsc.1 
ENSMUST00000360385.1 ENSMUSG00000140587 ENSMUST00000360385.1 ENSMUSG00000140587 (from geneSymbol) uc337vsj.1 uc337vsj.1 
ENSMUST00000360388.1 ENSMUSG00000140588 ENSMUST00000360388.1 ENSMUSG00000140588 (from geneSymbol) uc337vsm.1 uc337vsm.1 
ENSMUST00000360389.1 ENSMUSG00000140589 ENSMUST00000360389.1 ENSMUSG00000140589 (from geneSymbol) uc337vsn.1 uc337vsn.1 
ENSMUST00000360396.1 ENSMUSG00000140590 ENSMUST00000360396.1 ENSMUSG00000140590 (from geneSymbol) uc337vsu.1 uc337vsu.1 
ENSMUST00000360397.1 ENSMUSG00000140591 ENSMUST00000360397.1 ENSMUSG00000140591 (from geneSymbol) uc337vsv.1 uc337vsv.1 
ENSMUST00000360398.1 ENSMUSG00000140592 ENSMUST00000360398.1 ENSMUSG00000140592 (from geneSymbol) uc337vsw.1 uc337vsw.1 
ENSMUST00000360403.1 ENSMUSG00000140593 ENSMUST00000360403.1 ENSMUSG00000140593 (from geneSymbol) uc337vtb.1 uc337vtb.1 
ENSMUST00000360405.1 ENSMUSG00000140594 ENSMUST00000360405.1 ENSMUSG00000140594 (from geneSymbol) uc337vtd.1 uc337vtd.1 
ENSMUST00000360407.1 Gm48940 ENSMUST00000360407.1 Gm48940 (from geneSymbol) uc337vtf.1 uc337vtf.1 
ENSMUST00000360408.1 ENSMUSG00000140595 ENSMUST00000360408.1 ENSMUSG00000140595 (from geneSymbol) uc337vtg.1 uc337vtg.1 
ENSMUST00000360412.1 ENSMUSG00000140596 ENSMUST00000360412.1 ENSMUSG00000140596 (from geneSymbol) uc337vtk.1 uc337vtk.1 
ENSMUST00000360414.1 ENSMUSG00000140597 ENSMUST00000360414.1 ENSMUSG00000140597 (from geneSymbol) uc337vtm.1 uc337vtm.1 
ENSMUST00000360415.1 ENSMUSG00000140598 ENSMUST00000360415.1 ENSMUSG00000140598 (from geneSymbol) uc337vtn.1 uc337vtn.1 
ENSMUST00000360416.1 ENSMUSG00000140599 ENSMUST00000360416.1 ENSMUSG00000140599 (from geneSymbol) uc337vto.1 uc337vto.1 
ENSMUST00000360417.1 ENSMUSG00000140600 ENSMUST00000360417.1 ENSMUSG00000140600 (from geneSymbol) uc337vtp.1 uc337vtp.1 
ENSMUST00000360419.1 ENSMUSG00000140601 ENSMUST00000360419.1 ENSMUSG00000140601 (from geneSymbol) uc337vtr.1 uc337vtr.1 
ENSMUST00000360422.1 ENSMUSG00000140603 ENSMUST00000360422.1 ENSMUSG00000140603 (from geneSymbol) uc337vtt.1 uc337vtt.1 
ENSMUST00000360423.1 ENSMUSG00000140604 ENSMUST00000360423.1 ENSMUSG00000140604 (from geneSymbol) uc337vtu.1 uc337vtu.1 
ENSMUST00000360424.1 ENSMUSG00000140605 ENSMUST00000360424.1 ENSMUSG00000140605 (from geneSymbol) uc337vtv.1 uc337vtv.1 
ENSMUST00000360427.1 ENSMUSG00000140606 ENSMUST00000360427.1 ENSMUSG00000140606 (from geneSymbol) uc337vty.1 uc337vty.1 
ENSMUST00000360437.1 ENSMUSG00000140607 ENSMUST00000360437.1 ENSMUSG00000140607 (from geneSymbol) uc337vui.1 uc337vui.1 
ENSMUST00000360441.1 ENSMUSG00000140608 ENSMUST00000360441.1 ENSMUSG00000140608 (from geneSymbol) uc337vum.1 uc337vum.1 
ENSMUST00000360442.1 Gm35585 ENSMUST00000360442.1 Gm35585 (from geneSymbol) AK035376 uc337vun.1 uc337vun.1 
ENSMUST00000360452.1 ENSMUSG00000140609 ENSMUST00000360452.1 ENSMUSG00000140609 (from geneSymbol) LF201840 uc337vux.1 uc337vux.1 
ENSMUST00000360454.1 ENSMUSG00000140610 ENSMUST00000360454.1 ENSMUSG00000140610 (from geneSymbol) uc337vuz.1 uc337vuz.1 
ENSMUST00000360459.1 ENSMUSG00000140612 ENSMUST00000360459.1 ENSMUSG00000140612 (from geneSymbol) uc337vvd.1 uc337vvd.1 
ENSMUST00000360460.1 ENSMUSG00000140613 ENSMUST00000360460.1 ENSMUSG00000140613 (from geneSymbol) uc337vve.1 uc337vve.1 
ENSMUST00000360461.1 ENSMUSG00000140614 ENSMUST00000360461.1 ENSMUSG00000140614 (from geneSymbol) uc337vvf.1 uc337vvf.1 
ENSMUST00000360463.1 ENSMUSG00000140615 ENSMUST00000360463.1 ENSMUSG00000140615 (from geneSymbol) uc337vvh.1 uc337vvh.1 
ENSMUST00000360466.1 ENSMUSG00000140616 ENSMUST00000360466.1 ENSMUSG00000140616 (from geneSymbol) uc337vvk.1 uc337vvk.1 
ENSMUST00000360467.1 ENSMUSG00000140617 ENSMUST00000360467.1 ENSMUSG00000140617 (from geneSymbol) uc337vvl.1 uc337vvl.1 
ENSMUST00000360469.1 ENSMUSG00000140618 ENSMUST00000360469.1 ENSMUSG00000140618 (from geneSymbol) uc337vvn.1 uc337vvn.1 
ENSMUST00000360474.1 ENSMUSG00000140619 ENSMUST00000360474.1 ENSMUSG00000140619 (from geneSymbol) uc337vvs.1 uc337vvs.1 
ENSMUST00000360475.1 ENSMUSG00000140620 ENSMUST00000360475.1 ENSMUSG00000140620 (from geneSymbol) uc337vvt.1 uc337vvt.1 
ENSMUST00000360478.1 ENSMUSG00000140621 ENSMUST00000360478.1 ENSMUSG00000140621 (from geneSymbol) uc337vvw.1 uc337vvw.1 
ENSMUST00000360479.1 ENSMUSG00000140622 ENSMUST00000360479.1 ENSMUSG00000140622 (from geneSymbol) uc337vvx.1 uc337vvx.1 
ENSMUST00000360481.1 ENSMUSG00000140623 ENSMUST00000360481.1 ENSMUSG00000140623 (from geneSymbol) uc337vvz.1 uc337vvz.1 
ENSMUST00000360482.1 ENSMUSG00000140624 ENSMUST00000360482.1 ENSMUSG00000140624 (from geneSymbol) AK133254 uc337vwa.1 uc337vwa.1 
ENSMUST00000360484.1 ENSMUSG00000140625 ENSMUST00000360484.1 ENSMUSG00000140625 (from geneSymbol) uc337vwc.1 uc337vwc.1 
ENSMUST00000360493.1 ENSMUSG00000140626 ENSMUST00000360493.1 ENSMUSG00000140626 (from geneSymbol) uc337vwl.1 uc337vwl.1 
ENSMUST00000360504.1 ENSMUSG00000140627 ENSMUST00000360504.1 ENSMUSG00000140627 (from geneSymbol) uc337vww.1 uc337vww.1 
ENSMUST00000360510.1 ENSMUSG00000140628 ENSMUST00000360510.1 ENSMUSG00000140628 (from geneSymbol) uc337vxc.1 uc337vxc.1 
ENSMUST00000360513.1 Gm26633 ENSMUST00000360513.1 Gm26633 (from geneSymbol) AK140111 uc337vxf.1 uc337vxf.1 
ENSMUST00000360523.1 ENSMUSG00000140629 ENSMUST00000360523.1 ENSMUSG00000140629 (from geneSymbol) uc337vxp.1 uc337vxp.1 
ENSMUST00000360525.1 ENSMUSG00000140630 ENSMUST00000360525.1 ENSMUSG00000140630 (from geneSymbol) uc337vxr.1 uc337vxr.1 
ENSMUST00000360532.1 4930408O17Rik ENSMUST00000360532.1 4930408O17Rik (from geneSymbol) AK015114 uc337vxy.1 uc337vxy.1 
ENSMUST00000360545.1 ENSMUSG00000140631 ENSMUST00000360545.1 ENSMUSG00000140631 (from geneSymbol) uc337vyj.1 uc337vyj.1 
ENSMUST00000360548.1 ENSMUSG00000140632 ENSMUST00000360548.1 ENSMUSG00000140632 (from geneSymbol) uc337vym.1 uc337vym.1 
ENSMUST00000360549.1 ENSMUSG00000140633 ENSMUST00000360549.1 ENSMUSG00000140633 (from geneSymbol) uc337vyn.1 uc337vyn.1 
ENSMUST00000360550.1 ENSMUSG00000140634 ENSMUST00000360550.1 ENSMUSG00000140634 (from geneSymbol) uc337vyo.1 uc337vyo.1 
ENSMUST00000360551.1 ENSMUSG00000140635 ENSMUST00000360551.1 ENSMUSG00000140635 (from geneSymbol) uc337vyp.1 uc337vyp.1 
ENSMUST00000360561.1 ENSMUSG00000140636 ENSMUST00000360561.1 ENSMUSG00000140636 (from geneSymbol) uc337vyz.1 uc337vyz.1 
ENSMUST00000360564.1 ENSMUSG00000140637 ENSMUST00000360564.1 ENSMUSG00000140637 (from geneSymbol) uc337vzc.1 uc337vzc.1 
ENSMUST00000360568.1 ENSMUSG00000140638 ENSMUST00000360568.1 ENSMUSG00000140638 (from geneSymbol) uc337vzf.1 uc337vzf.1 
ENSMUST00000360571.1 ENSMUSG00000140639 ENSMUST00000360571.1 ENSMUSG00000140639 (from geneSymbol) uc337vzi.1 uc337vzi.1 
ENSMUST00000360572.1 ENSMUSG00000140640 ENSMUST00000360572.1 ENSMUSG00000140640 (from geneSymbol) uc337vzj.1 uc337vzj.1 
ENSMUST00000360587.1 ENSMUSG00000140641 ENSMUST00000360587.1 ENSMUSG00000140641 (from geneSymbol) uc337vzy.1 uc337vzy.1 
ENSMUST00000360588.1 ENSMUSG00000140642 ENSMUST00000360588.1 ENSMUSG00000140642 (from geneSymbol) uc337vzz.1 uc337vzz.1 
ENSMUST00000360589.1 ENSMUSG00000140643 ENSMUST00000360589.1 ENSMUSG00000140643 (from geneSymbol) uc337waa.1 uc337waa.1 
ENSMUST00000360630.1 ENSMUSG00000140644 ENSMUST00000360630.1 ENSMUSG00000140644 (from geneSymbol) uc337wbp.1 uc337wbp.1 
ENSMUST00000360631.1 ENSMUSG00000140645 ENSMUST00000360631.1 ENSMUSG00000140645 (from geneSymbol) uc337wbq.1 uc337wbq.1 
ENSMUST00000360632.1 ENSMUSG00000140646 ENSMUST00000360632.1 ENSMUSG00000140646 (from geneSymbol) uc337wbr.1 uc337wbr.1 
ENSMUST00000360635.1 ENSMUSG00000140647 ENSMUST00000360635.1 ENSMUSG00000140647 (from geneSymbol) uc337wbu.1 uc337wbu.1 
ENSMUST00000360636.1 1700081N11Rik ENSMUST00000360636.1 1700081N11Rik (from geneSymbol) AK006973 uc337wbv.1 uc337wbv.1 
ENSMUST00000360639.1 ENSMUSG00000140648 ENSMUST00000360639.1 ENSMUSG00000140648 (from geneSymbol) uc337wby.1 uc337wby.1 
ENSMUST00000360640.1 ENSMUSG00000140649 ENSMUST00000360640.1 ENSMUSG00000140649 (from geneSymbol) uc337wbz.1 uc337wbz.1 
ENSMUST00000360641.1 ENSMUSG00000140650 ENSMUST00000360641.1 ENSMUSG00000140650 (from geneSymbol) uc337wca.1 uc337wca.1 
ENSMUST00000360642.1 ENSMUSG00000140651 ENSMUST00000360642.1 ENSMUSG00000140651 (from geneSymbol) LF193734 uc337wcb.1 uc337wcb.1 
ENSMUST00000360643.1 ENSMUSG00000140652 ENSMUST00000360643.1 ENSMUSG00000140652 (from geneSymbol) uc337wcc.1 uc337wcc.1 
ENSMUST00000360644.1 ENSMUSG00000140653 ENSMUST00000360644.1 ENSMUSG00000140653 (from geneSymbol) BC079904 uc337wcd.1 uc337wcd.1 
ENSMUST00000360647.1 ENSMUSG00000140654 ENSMUST00000360647.1 ENSMUSG00000140654 (from geneSymbol) uc337wcg.1 uc337wcg.1 
ENSMUST00000360648.1 ENSMUSG00000140655 ENSMUST00000360648.1 ENSMUSG00000140655 (from geneSymbol) uc337wch.1 uc337wch.1 
ENSMUST00000360649.1 ENSMUSG00000140656 ENSMUST00000360649.1 ENSMUSG00000140656 (from geneSymbol) uc337wci.1 uc337wci.1 
ENSMUST00000360653.1 ENSMUSG00000140657 ENSMUST00000360653.1 ENSMUSG00000140657 (from geneSymbol) uc337wcm.1 uc337wcm.1 
ENSMUST00000360662.1 ENSMUSG00000140659 ENSMUST00000360662.1 ENSMUSG00000140659 (from geneSymbol) uc337wcu.1 uc337wcu.1 
ENSMUST00000360663.1 ENSMUSG00000140660 ENSMUST00000360663.1 ENSMUSG00000140660 (from geneSymbol) uc337wcv.1 uc337wcv.1 
ENSMUST00000360664.1 Gm49540 ENSMUST00000360664.1 Gm49540 (from geneSymbol) uc337wcw.1 uc337wcw.1 
ENSMUST00000360678.1 ENSMUSG00000140661 ENSMUST00000360678.1 ENSMUSG00000140661 (from geneSymbol) uc337wdk.1 uc337wdk.1 
ENSMUST00000360679.1 ENSMUSG00000140662 ENSMUST00000360679.1 ENSMUSG00000140662 (from geneSymbol) uc337wdl.1 uc337wdl.1 
ENSMUST00000360687.1 Gm27184 ENSMUST00000360687.1 Gm27184 (from geneSymbol) AK053246 uc337wdt.1 uc337wdt.1 
ENSMUST00000360691.1 ENSMUSG00000140663 ENSMUST00000360691.1 ENSMUSG00000140663 (from geneSymbol) uc337wdx.1 uc337wdx.1 
ENSMUST00000360692.1 ENSMUSG00000140664 ENSMUST00000360692.1 ENSMUSG00000140664 (from geneSymbol) uc337wdy.1 uc337wdy.1 
ENSMUST00000360698.1 ENSMUSG00000140665 ENSMUST00000360698.1 ENSMUSG00000140665 (from geneSymbol) uc337wee.1 uc337wee.1 
ENSMUST00000360699.1 ENSMUSG00000140666 ENSMUST00000360699.1 ENSMUSG00000140666 (from geneSymbol) uc337wef.1 uc337wef.1 
ENSMUST00000360704.1 ENSMUSG00000140667 ENSMUST00000360704.1 ENSMUSG00000140667 (from geneSymbol) uc337wek.1 uc337wek.1 
ENSMUST00000360708.1 Gm6556 ENSMUST00000360708.1 Gm6556 (from geneSymbol) uc337weo.1 uc337weo.1 
ENSMUST00000360713.1 ENSMUSG00000140668 ENSMUST00000360713.1 ENSMUSG00000140668 (from geneSymbol) uc337wet.1 uc337wet.1 
ENSMUST00000360714.1 ENSMUSG00000140669 ENSMUST00000360714.1 ENSMUSG00000140669 (from geneSymbol) KY467949 uc337weu.1 uc337weu.1 
ENSMUST00000360727.1 ENSMUSG00000140670 ENSMUST00000360727.1 ENSMUSG00000140670 (from geneSymbol) uc337wfh.1 uc337wfh.1 
ENSMUST00000360733.1 ENSMUSG00000140671 ENSMUST00000360733.1 ENSMUSG00000140671 (from geneSymbol) uc337wfn.1 uc337wfn.1 
ENSMUST00000360734.1 ENSMUSG00000140672 ENSMUST00000360734.1 ENSMUSG00000140672 (from geneSymbol) MH220364 uc337wfo.1 uc337wfo.1 
ENSMUST00000360737.1 2310044K18Rik ENSMUST00000360737.1 2310044K18Rik (from geneSymbol) uc337wfr.1 uc337wfr.1 
ENSMUST00000360741.1 ENSMUSG00000140673 ENSMUST00000360741.1 ENSMUSG00000140673 (from geneSymbol) uc337wfv.1 uc337wfv.1 
ENSMUST00000360743.1 ENSMUSG00000140675 ENSMUST00000360743.1 ENSMUSG00000140675 (from geneSymbol) uc337wfw.1 uc337wfw.1 
ENSMUST00000360745.1 ENSMUSG00000140676 ENSMUST00000360745.1 ENSMUSG00000140676 (from geneSymbol) uc337wfy.1 uc337wfy.1 
ENSMUST00000360746.1 ENSMUSG00000140677 ENSMUST00000360746.1 ENSMUSG00000140677 (from geneSymbol) uc337wfz.1 uc337wfz.1 
ENSMUST00000360748.1 Gm14641 ENSMUST00000360748.1 Gm14641 (from geneSymbol) uc337wga.1 uc337wga.1 
ENSMUST00000360749.1 ENSMUSG00000140679 ENSMUST00000360749.1 ENSMUSG00000140679 (from geneSymbol) uc337wgb.1 uc337wgb.1 
ENSMUST00000360750.1 Gm28411 ENSMUST00000360750.1 Gm28411 (from geneSymbol) AK006768 uc337wgc.1 uc337wgc.1 
ENSMUST00000360765.1 Gm20208 ENSMUST00000360765.1 Gm20208 (from geneSymbol) AK138505 uc337wgr.1 uc337wgr.1 
ENSMUST00000360785.1 ENSMUSG00000140680 ENSMUST00000360785.1 ENSMUSG00000140680 (from geneSymbol) uc337whj.1 uc337whj.1 
ENSMUST00000360786.1 ENSMUSG00000140681 ENSMUST00000360786.1 ENSMUSG00000140681 (from geneSymbol) uc337whk.1 uc337whk.1 
ENSMUST00000360787.1 ENSMUSG00000140682 ENSMUST00000360787.1 ENSMUSG00000140682 (from geneSymbol) uc337whl.1 uc337whl.1 
ENSMUST00000360795.1 ENSMUSG00000140683 ENSMUST00000360795.1 ENSMUSG00000140683 (from geneSymbol) uc337wht.1 uc337wht.1 
ENSMUST00000360796.1 ENSMUSG00000140684 ENSMUST00000360796.1 ENSMUSG00000140684 (from geneSymbol) uc337whu.1 uc337whu.1 
ENSMUST00000360798.1 ENSMUSG00000140685 ENSMUST00000360798.1 ENSMUSG00000140685 (from geneSymbol) uc337whw.1 uc337whw.1 
ENSMUST00000360799.1 ENSMUSG00000140686 ENSMUST00000360799.1 ENSMUSG00000140686 (from geneSymbol) uc337whx.1 uc337whx.1 
ENSMUST00000360800.1 ENSMUSG00000140687 ENSMUST00000360800.1 ENSMUSG00000140687 (from geneSymbol) uc337why.1 uc337why.1 
ENSMUST00000360803.1 ENSMUSG00000140688 ENSMUST00000360803.1 ENSMUSG00000140688 (from geneSymbol) uc337wib.1 uc337wib.1 
ENSMUST00000360805.1 ENSMUSG00000140689 ENSMUST00000360805.1 ENSMUSG00000140689 (from geneSymbol) uc337wid.1 uc337wid.1 
ENSMUST00000360807.1 H3f3aos ENSMUST00000360807.1 H3f3aos (from geneSymbol) uc337wif.1 uc337wif.1 
ENSMUST00000360815.1 ENSMUSG00000140690 ENSMUST00000360815.1 ENSMUSG00000140690 (from geneSymbol) uc337win.1 uc337win.1 
ENSMUST00000360816.1 ENSMUSG00000140691 ENSMUST00000360816.1 ENSMUSG00000140691 (from geneSymbol) uc337wio.1 uc337wio.1 
ENSMUST00000360817.1 ENSMUSG00000140692 ENSMUST00000360817.1 ENSMUSG00000140692 (from geneSymbol) uc337wip.1 uc337wip.1 
ENSMUST00000360820.1 ENSMUSG00000140693 ENSMUST00000360820.1 ENSMUSG00000140693 (from geneSymbol) uc337wis.1 uc337wis.1 
ENSMUST00000360821.1 ENSMUSG00000140694 ENSMUST00000360821.1 ENSMUSG00000140694 (from geneSymbol) uc337wit.1 uc337wit.1 
ENSMUST00000360822.1 ENSMUSG00000140695 ENSMUST00000360822.1 ENSMUSG00000140695 (from geneSymbol) uc337wiu.1 uc337wiu.1 
ENSMUST00000360824.1 ENSMUSG00000140696 ENSMUST00000360824.1 ENSMUSG00000140696 (from geneSymbol) uc337wiw.1 uc337wiw.1 
ENSMUST00000360833.1 ENSMUSG00000140697 ENSMUST00000360833.1 ENSMUSG00000140697 (from geneSymbol) uc337wjf.1 uc337wjf.1 
ENSMUST00000360834.1 ENSMUSG00000140698 ENSMUST00000360834.1 ENSMUSG00000140698 (from geneSymbol) AK084690 uc337wjg.1 uc337wjg.1 
ENSMUST00000360835.1 ENSMUSG00000140699 ENSMUST00000360835.1 ENSMUSG00000140699 (from geneSymbol) uc337wjh.1 uc337wjh.1 
ENSMUST00000360838.1 ENSMUSG00000140700 ENSMUST00000360838.1 ENSMUSG00000140700 (from geneSymbol) uc337wjk.1 uc337wjk.1 
ENSMUST00000360840.1 ENSMUSG00000140701 ENSMUST00000360840.1 ENSMUSG00000140701 (from geneSymbol) uc337wjm.1 uc337wjm.1 
ENSMUST00000360842.1 ENSMUSG00000140702 ENSMUST00000360842.1 ENSMUSG00000140702 (from geneSymbol) uc337wjo.1 uc337wjo.1 
ENSMUST00000360845.1 ENSMUSG00000140703 ENSMUST00000360845.1 ENSMUSG00000140703 (from geneSymbol) uc337wjr.1 uc337wjr.1 
ENSMUST00000360846.1 ENSMUSG00000140704 ENSMUST00000360846.1 ENSMUSG00000140704 (from geneSymbol) uc337wjs.1 uc337wjs.1 
ENSMUST00000360848.1 ENSMUSG00000140705 ENSMUST00000360848.1 ENSMUSG00000140705 (from geneSymbol) uc337wju.1 uc337wju.1 
ENSMUST00000360849.1 ENSMUSG00000140706 ENSMUST00000360849.1 ENSMUSG00000140706 (from geneSymbol) uc337wjv.1 uc337wjv.1 
ENSMUST00000360851.1 ENSMUSG00000140707 ENSMUST00000360851.1 ENSMUSG00000140707 (from geneSymbol) uc337wjx.1 uc337wjx.1 
ENSMUST00000360852.1 ENSMUSG00000140708 ENSMUST00000360852.1 ENSMUSG00000140708 (from geneSymbol) uc337wjy.1 uc337wjy.1 
ENSMUST00000360858.1 ENSMUSG00000140709 ENSMUST00000360858.1 ENSMUSG00000140709 (from geneSymbol) uc337wke.1 uc337wke.1 
ENSMUST00000360859.1 ENSMUSG00000140710 ENSMUST00000360859.1 ENSMUSG00000140710 (from geneSymbol) uc337wkf.1 uc337wkf.1 
ENSMUST00000360860.1 ENSMUSG00000140711 ENSMUST00000360860.1 ENSMUSG00000140711 (from geneSymbol) uc337wkg.1 uc337wkg.1 
ENSMUST00000360866.1 ENSMUSG00000140712 ENSMUST00000360866.1 ENSMUSG00000140712 (from geneSymbol) uc337wkm.1 uc337wkm.1 
ENSMUST00000360868.1 ENSMUSG00000140713 ENSMUST00000360868.1 ENSMUSG00000140713 (from geneSymbol) uc337wko.1 uc337wko.1 
ENSMUST00000360869.1 ENSMUSG00000140714 ENSMUST00000360869.1 ENSMUSG00000140714 (from geneSymbol) uc337wkp.1 uc337wkp.1 
ENSMUST00000360873.1 Gm9867 ENSMUST00000360873.1 Gm9867 (from geneSymbol) uc337wkt.1 uc337wkt.1 
ENSMUST00000360878.1 ENSMUSG00000140716 ENSMUST00000360878.1 ENSMUSG00000140716 (from geneSymbol) uc337wky.1 uc337wky.1 
ENSMUST00000360879.1 ENSMUSG00000140717 ENSMUST00000360879.1 ENSMUSG00000140717 (from geneSymbol) uc337wkz.1 uc337wkz.1 
ENSMUST00000360880.1 ENSMUSG00000140718 ENSMUST00000360880.1 ENSMUSG00000140718 (from geneSymbol) uc337wla.1 uc337wla.1 
ENSMUST00000360882.1 ENSMUSG00000140719 ENSMUST00000360882.1 ENSMUSG00000140719 (from geneSymbol) uc337wlc.1 uc337wlc.1 
ENSMUST00000360885.1 ENSMUSG00000140720 ENSMUST00000360885.1 ENSMUSG00000140720 (from geneSymbol) uc337wlf.1 uc337wlf.1 
ENSMUST00000360886.1 ENSMUSG00000140721 ENSMUST00000360886.1 ENSMUSG00000140721 (from geneSymbol) uc337wlg.1 uc337wlg.1 
ENSMUST00000360888.1 ENSMUSG00000140722 ENSMUST00000360888.1 ENSMUSG00000140722 (from geneSymbol) uc337wli.1 uc337wli.1 
ENSMUST00000360889.1 ENSMUSG00000140723 ENSMUST00000360889.1 ENSMUSG00000140723 (from geneSymbol) uc337wlj.1 uc337wlj.1 
ENSMUST00000360893.1 ENSMUSG00000140724 ENSMUST00000360893.1 ENSMUSG00000140724 (from geneSymbol) uc337wln.1 uc337wln.1 
ENSMUST00000360895.1 1700021G15Rik ENSMUST00000360895.1 1700021G15Rik (from geneSymbol) AK006204 uc337wlp.1 uc337wlp.1 
ENSMUST00000360899.1 ENSMUSG00000140725 ENSMUST00000360899.1 ENSMUSG00000140725 (from geneSymbol) uc337wlt.1 uc337wlt.1 
ENSMUST00000360900.1 4930471D02Rik ENSMUST00000360900.1 4930471D02Rik (from geneSymbol) AK015546 uc337wlu.1 uc337wlu.1 
ENSMUST00000360903.1 ENSMUSG00000140726 ENSMUST00000360903.1 ENSMUSG00000140726 (from geneSymbol) uc337wlx.1 uc337wlx.1 
ENSMUST00000360908.1 Gm35439 ENSMUST00000360908.1 Gm35439 (from geneSymbol) AK137696 uc337wmb.1 uc337wmb.1 
ENSMUST00000360922.1 ENSMUSG00000140727 ENSMUST00000360922.1 ENSMUSG00000140727 (from geneSymbol) uc337wmp.1 uc337wmp.1 
ENSMUST00000360929.1 ENSMUSG00000140728 ENSMUST00000360929.1 ENSMUSG00000140728 (from geneSymbol) uc337wmw.1 uc337wmw.1 
ENSMUST00000360930.1 ENSMUSG00000140729 ENSMUST00000360930.1 ENSMUSG00000140729 (from geneSymbol) uc337wmx.1 uc337wmx.1 
ENSMUST00000360937.1 Gm30600 ENSMUST00000360937.1 Gm30600 (from geneSymbol) uc337wne.1 uc337wne.1 
ENSMUST00000360974.1 ENSMUSG00000140730 ENSMUST00000360974.1 ENSMUSG00000140730 (from geneSymbol) uc337wop.1 uc337wop.1 
ENSMUST00000360976.1 ENSMUSG00000140732 ENSMUST00000360976.1 ENSMUSG00000140732 (from geneSymbol) uc337woq.1 uc337woq.1 
ENSMUST00000360978.1 ENSMUSG00000140733 ENSMUST00000360978.1 ENSMUSG00000140733 (from geneSymbol) uc337wos.1 uc337wos.1 
ENSMUST00000360980.1 ENSMUSG00000140734 ENSMUST00000360980.1 ENSMUSG00000140734 (from geneSymbol) uc337wou.1 uc337wou.1 
ENSMUST00000360985.1 ENSMUSG00000140735 ENSMUST00000360985.1 ENSMUSG00000140735 (from geneSymbol) uc337woz.1 uc337woz.1 
ENSMUST00000360987.1 ENSMUSG00000140736 ENSMUST00000360987.1 ENSMUSG00000140736 (from geneSymbol) uc337wpb.1 uc337wpb.1 
ENSMUST00000360989.1 ENSMUSG00000140737 ENSMUST00000360989.1 ENSMUSG00000140737 (from geneSymbol) LF204908 uc337wpd.1 uc337wpd.1 
ENSMUST00000360990.1 ENSMUSG00000140738 ENSMUST00000360990.1 ENSMUSG00000140738 (from geneSymbol) uc337wpe.1 uc337wpe.1 
ENSMUST00000360992.1 ENSMUSG00000140739 ENSMUST00000360992.1 ENSMUSG00000140739 (from geneSymbol) uc337wpg.1 uc337wpg.1 
ENSMUST00000360995.1 A430093F15Rik ENSMUST00000360995.1 A430093F15Rik (from geneSymbol) AK079853 uc337wpj.1 uc337wpj.1 
ENSMUST00000361013.1 ENSMUSG00000140740 ENSMUST00000361013.1 ENSMUSG00000140740 (from geneSymbol) uc337wqb.1 uc337wqb.1 
ENSMUST00000361032.1 ENSMUSG00000140741 ENSMUST00000361032.1 ENSMUSG00000140741 (from geneSymbol) uc337wqu.1 uc337wqu.1 
ENSMUST00000361039.1 ENSMUSG00000140742 ENSMUST00000361039.1 ENSMUSG00000140742 (from geneSymbol) uc337wrb.1 uc337wrb.1 
ENSMUST00000361041.1 ENSMUSG00000140743 ENSMUST00000361041.1 ENSMUSG00000140743 (from geneSymbol) uc337wrd.1 uc337wrd.1 
ENSMUST00000361042.1 ENSMUSG00000140744 ENSMUST00000361042.1 ENSMUSG00000140744 (from geneSymbol) uc337wre.1 uc337wre.1 
ENSMUST00000361043.1 ENSMUSG00000140745 ENSMUST00000361043.1 ENSMUSG00000140745 (from geneSymbol) uc337wrf.1 uc337wrf.1 
ENSMUST00000361045.1 Gm32059 ENSMUST00000361045.1 Gm32059 (from geneSymbol) NR_190287 uc337wrh.1 uc337wrh.1 
ENSMUST00000361046.1 ENSMUSG00000140747 ENSMUST00000361046.1 ENSMUSG00000140747 (from geneSymbol) uc337wri.1 uc337wri.1 
ENSMUST00000361047.1 ENSMUSG00000140748 ENSMUST00000361047.1 ENSMUSG00000140748 (from geneSymbol) uc337wrj.1 uc337wrj.1 
ENSMUST00000361048.1 ENSMUSG00000140749 ENSMUST00000361048.1 ENSMUSG00000140749 (from geneSymbol) uc337wrk.1 uc337wrk.1 
ENSMUST00000361049.1 ENSMUSG00000140750 ENSMUST00000361049.1 ENSMUSG00000140750 (from geneSymbol) uc337wrl.1 uc337wrl.1 
ENSMUST00000361053.1 ENSMUSG00000140751 ENSMUST00000361053.1 ENSMUSG00000140751 (from geneSymbol) uc337wrp.1 uc337wrp.1 
ENSMUST00000361055.1 ENSMUSG00000140752 ENSMUST00000361055.1 ENSMUSG00000140752 (from geneSymbol) uc337wrr.1 uc337wrr.1 
ENSMUST00000361056.1 ENSMUSG00000140753 ENSMUST00000361056.1 ENSMUSG00000140753 (from geneSymbol) uc337wrs.1 uc337wrs.1 
ENSMUST00000361058.1 ENSMUSG00000140754 ENSMUST00000361058.1 ENSMUSG00000140754 (from geneSymbol) uc337wru.1 uc337wru.1 
ENSMUST00000361060.1 Gm45024 ENSMUST00000361060.1 Gm45024 (from geneSymbol) uc337wrw.1 uc337wrw.1 
ENSMUST00000361061.1 ENSMUSG00000140755 ENSMUST00000361061.1 ENSMUSG00000140755 (from geneSymbol) uc337wrx.1 uc337wrx.1 
ENSMUST00000361072.1 ENSMUSG00000140756 ENSMUST00000361072.1 ENSMUSG00000140756 (from geneSymbol) uc337wsi.1 uc337wsi.1 
ENSMUST00000361075.1 ENSMUSG00000140757 ENSMUST00000361075.1 ENSMUSG00000140757 (from geneSymbol) uc337wsl.1 uc337wsl.1 
ENSMUST00000361077.1 ENSMUSG00000140758 ENSMUST00000361077.1 ENSMUSG00000140758 (from geneSymbol) uc337wsn.1 uc337wsn.1 
ENSMUST00000361084.1 ENSMUSG00000140759 ENSMUST00000361084.1 ENSMUSG00000140759 (from geneSymbol) uc337wsu.1 uc337wsu.1 
ENSMUST00000361093.1 ENSMUSG00000140760 ENSMUST00000361093.1 ENSMUSG00000140760 (from geneSymbol) uc337wtc.1 uc337wtc.1 
ENSMUST00000361103.1 ENSMUSG00000140761 ENSMUST00000361103.1 ENSMUSG00000140761 (from geneSymbol) uc337wtm.1 uc337wtm.1 
ENSMUST00000361115.1 ENSMUSG00000140762 ENSMUST00000361115.1 ENSMUSG00000140762 (from geneSymbol) uc337wty.1 uc337wty.1 
ENSMUST00000361116.1 ENSMUSG00000140763 ENSMUST00000361116.1 ENSMUSG00000140763 (from geneSymbol) uc337wtz.1 uc337wtz.1 
ENSMUST00000361118.1 ENSMUSG00000140764 ENSMUST00000361118.1 ENSMUSG00000140764 (from geneSymbol) uc337wub.1 uc337wub.1 
ENSMUST00000361121.1 ENSMUSG00000140765 ENSMUST00000361121.1 ENSMUSG00000140765 (from geneSymbol) uc337wue.1 uc337wue.1 
ENSMUST00000361128.1 Gm7931 ENSMUST00000361128.1 predicted pseudogene 7931 (from RefSeq NR_169028.1) NR_169028 uc337wul.1 uc337wul.1 
ENSMUST00000361130.1 ENSMUSG00000140767 ENSMUST00000361130.1 ENSMUSG00000140767 (from geneSymbol) AK007112 uc337wun.1 uc337wun.1 
ENSMUST00000361132.1 Gm11205 ENSMUST00000361132.1 Gm11205 (from geneSymbol) uc337wup.1 uc337wup.1 
ENSMUST00000361140.1 ENSMUSG00000140768 ENSMUST00000361140.1 ENSMUSG00000140768 (from geneSymbol) uc337wux.1 uc337wux.1 
ENSMUST00000361142.1 ENSMUSG00000140769 ENSMUST00000361142.1 ENSMUSG00000140769 (from geneSymbol) uc337wuz.1 uc337wuz.1 
ENSMUST00000361145.1 ENSMUSG00000140770 ENSMUST00000361145.1 ENSMUSG00000140770 (from geneSymbol) uc337wvc.1 uc337wvc.1 
ENSMUST00000361146.1 Gm33459 ENSMUST00000361146.1 Gm33459 (from geneSymbol) uc337wvd.1 uc337wvd.1 
ENSMUST00000361171.1 Gm16677 ENSMUST00000361171.1 Gm16677 (from geneSymbol) AK046150 uc337wwc.1 uc337wwc.1 
ENSMUST00000361218.1 ENSMUSG00000140771 ENSMUST00000361218.1 ENSMUSG00000140771 (from geneSymbol) uc337wxx.1 uc337wxx.1 
ENSMUST00000361219.1 ENSMUSG00000140772 ENSMUST00000361219.1 ENSMUSG00000140772 (from geneSymbol) uc337wxy.1 uc337wxy.1 
ENSMUST00000361220.1 ENSMUSG00000140773 ENSMUST00000361220.1 ENSMUSG00000140773 (from geneSymbol) uc337wxz.1 uc337wxz.1 
ENSMUST00000361228.1 ENSMUSG00000140774 ENSMUST00000361228.1 ENSMUSG00000140774 (from geneSymbol) uc337wyh.1 uc337wyh.1 
ENSMUST00000361232.1 ENSMUSG00000140775 ENSMUST00000361232.1 ENSMUSG00000140775 (from geneSymbol) uc337wyl.1 uc337wyl.1 
ENSMUST00000361233.1 ENSMUSG00000140776 ENSMUST00000361233.1 ENSMUSG00000140776 (from geneSymbol) uc337wym.1 uc337wym.1 
ENSMUST00000361237.1 ENSMUSG00000140777 ENSMUST00000361237.1 ENSMUSG00000140777 (from geneSymbol) uc337wyq.1 uc337wyq.1 
ENSMUST00000361253.1 ENSMUSG00000140778 ENSMUST00000361253.1 ENSMUSG00000140778 (from geneSymbol) uc337wzg.1 uc337wzg.1 
ENSMUST00000361261.1 ENSMUSG00000140779 ENSMUST00000361261.1 ENSMUSG00000140779 (from geneSymbol) uc337wzo.1 uc337wzo.1 
ENSMUST00000361262.1 ENSMUSG00000140780 ENSMUST00000361262.1 ENSMUSG00000140780 (from geneSymbol) uc337wzp.1 uc337wzp.1 
ENSMUST00000361263.1 ENSMUSG00000140781 ENSMUST00000361263.1 ENSMUSG00000140781 (from geneSymbol) uc337wzq.1 uc337wzq.1 
ENSMUST00000361265.1 ENSMUSG00000140783 ENSMUST00000361265.1 ENSMUSG00000140783 (from geneSymbol) uc337wzr.1 uc337wzr.1 
ENSMUST00000361267.1 ENSMUSG00000140784 ENSMUST00000361267.1 ENSMUSG00000140784 (from geneSymbol) uc337wzt.1 uc337wzt.1 
ENSMUST00000361271.1 ENSMUSG00000140785 ENSMUST00000361271.1 ENSMUSG00000140785 (from geneSymbol) uc337wzx.1 uc337wzx.1 
ENSMUST00000361274.1 ENSMUSG00000140786 ENSMUST00000361274.1 ENSMUSG00000140786 (from geneSymbol) uc337xaa.1 uc337xaa.1 
ENSMUST00000361276.1 Gm12720 ENSMUST00000361276.1 Gm12720 (from geneSymbol) uc337xac.1 uc337xac.1 
ENSMUST00000361281.1 4930528H21Rik ENSMUST00000361281.1 4930528H21Rik (from geneSymbol) AK019707 uc337xah.1 uc337xah.1 
ENSMUST00000361284.1 Gm50181 ENSMUST00000361284.1 Gm50181 (from geneSymbol) uc337xak.1 uc337xak.1 
ENSMUST00000361291.1 ENSMUSG00000140787 ENSMUST00000361291.1 ENSMUSG00000140787 (from geneSymbol) uc337xar.1 uc337xar.1 
ENSMUST00000361293.1 ENSMUSG00000140788 ENSMUST00000361293.1 ENSMUSG00000140788 (from geneSymbol) uc337xat.1 uc337xat.1 
ENSMUST00000361297.1 ENSMUSG00000140789 ENSMUST00000361297.1 ENSMUSG00000140789 (from geneSymbol) uc337xax.1 uc337xax.1 
ENSMUST00000361298.1 ENSMUSG00000140790 ENSMUST00000361298.1 ENSMUSG00000140790 (from geneSymbol) uc337xay.1 uc337xay.1 
ENSMUST00000361299.1 ENSMUSG00000140791 ENSMUST00000361299.1 ENSMUSG00000140791 (from geneSymbol) uc337xaz.1 uc337xaz.1 
ENSMUST00000361302.1 ENSMUSG00000140792 ENSMUST00000361302.1 ENSMUSG00000140792 (from geneSymbol) uc337xbc.1 uc337xbc.1 
ENSMUST00000361307.1 ENSMUSG00000140793 ENSMUST00000361307.1 ENSMUSG00000140793 (from geneSymbol) uc337xbh.1 uc337xbh.1 
ENSMUST00000361308.1 ENSMUSG00000140794 ENSMUST00000361308.1 ENSMUSG00000140794 (from geneSymbol) uc337xbi.1 uc337xbi.1 
ENSMUST00000361309.1 ENSMUSG00000140795 ENSMUST00000361309.1 ENSMUSG00000140795 (from geneSymbol) uc337xbj.1 uc337xbj.1 
ENSMUST00000361310.1 ENSMUSG00000140796 ENSMUST00000361310.1 ENSMUSG00000140796 (from geneSymbol) uc337xbk.1 uc337xbk.1 
ENSMUST00000361324.1 ENSMUSG00000140797 ENSMUST00000361324.1 ENSMUSG00000140797 (from geneSymbol) uc337xby.1 uc337xby.1 
ENSMUST00000361327.1 ENSMUSG00000140798 ENSMUST00000361327.1 ENSMUSG00000140798 (from geneSymbol) uc337xcb.1 uc337xcb.1 
ENSMUST00000361328.1 ENSMUSG00000140799 ENSMUST00000361328.1 ENSMUSG00000140799 (from geneSymbol) uc337xcc.1 uc337xcc.1 
ENSMUST00000361330.1 Gm15395 ENSMUST00000361330.1 Gm15395 (from geneSymbol) uc337xce.1 uc337xce.1 
ENSMUST00000361334.1 ENSMUSG00000140800 ENSMUST00000361334.1 ENSMUSG00000140800 (from geneSymbol) uc337xci.1 uc337xci.1 
ENSMUST00000361335.1 ENSMUSG00000140801 ENSMUST00000361335.1 ENSMUSG00000140801 (from geneSymbol) uc337xcj.1 uc337xcj.1 
ENSMUST00000361336.1 ENSMUSG00000140802 ENSMUST00000361336.1 ENSMUSG00000140802 (from geneSymbol) uc337xck.1 uc337xck.1 
ENSMUST00000361338.1 ENSMUSG00000140803 ENSMUST00000361338.1 ENSMUSG00000140803 (from geneSymbol) uc337xcm.1 uc337xcm.1 
ENSMUST00000361342.1 Gm50332 ENSMUST00000361342.1 Gm50332 (from geneSymbol) uc337xcq.1 uc337xcq.1 
ENSMUST00000361344.1 ENSMUSG00000140804 ENSMUST00000361344.1 ENSMUSG00000140804 (from geneSymbol) uc337xcs.1 uc337xcs.1 
ENSMUST00000361351.1 Gm15886 ENSMUST00000361351.1 Gm15886 (from geneSymbol) AK016162 uc337xcz.1 uc337xcz.1 
ENSMUST00000361357.1 ENSMUSG00000140805 ENSMUST00000361357.1 ENSMUSG00000140805 (from geneSymbol) uc337xdf.1 uc337xdf.1 
ENSMUST00000361359.1 ENSMUSG00000140806 ENSMUST00000361359.1 ENSMUSG00000140806 (from geneSymbol) uc337xdh.1 uc337xdh.1 
ENSMUST00000361363.1 4930470O06Rik ENSMUST00000361363.1 4930470O06Rik (from geneSymbol) AK015539 uc337xdl.1 uc337xdl.1 
ENSMUST00000361373.1 4930430J02Rik ENSMUST00000361373.1 4930430J02Rik (from geneSymbol) AK015253 uc337xdv.1 uc337xdv.1 
ENSMUST00000361377.1 ENSMUSG00000140808 ENSMUST00000361377.1 ENSMUSG00000140808 (from geneSymbol) uc337xdz.1 uc337xdz.1 
ENSMUST00000361378.1 ENSMUSG00000140809 ENSMUST00000361378.1 ENSMUSG00000140809 (from geneSymbol) uc337xea.1 uc337xea.1 
ENSMUST00000361384.1 Gm27174 ENSMUST00000361384.1 Gm27174 (from geneSymbol) uc337xeg.1 uc337xeg.1 
ENSMUST00000361418.1 ENSMUSG00000140810 ENSMUST00000361418.1 ENSMUSG00000140810 (from geneSymbol) uc337xfo.1 uc337xfo.1 
ENSMUST00000361419.1 ENSMUSG00000140811 ENSMUST00000361419.1 ENSMUSG00000140811 (from geneSymbol) uc337xfp.1 uc337xfp.1 
ENSMUST00000361421.1 4930597A21Rik ENSMUST00000361421.1 4930597A21Rik (from geneSymbol) AK016402 uc337xfr.1 uc337xfr.1 
ENSMUST00000361426.1 ENSMUSG00000140812 ENSMUST00000361426.1 ENSMUSG00000140812 (from geneSymbol) uc337xfw.1 uc337xfw.1 
ENSMUST00000361427.1 ENSMUSG00000140813 ENSMUST00000361427.1 ENSMUSG00000140813 (from geneSymbol) uc337xfx.1 uc337xfx.1 
ENSMUST00000361428.1 ENSMUSG00000140814 ENSMUST00000361428.1 ENSMUSG00000140814 (from geneSymbol) uc337xfy.1 uc337xfy.1 
ENSMUST00000361431.1 ENSMUSG00000140815 ENSMUST00000361431.1 ENSMUSG00000140815 (from geneSymbol) uc337xgb.1 uc337xgb.1 
ENSMUST00000361433.1 Gm35065 ENSMUST00000361433.1 Gm35065 (from geneSymbol) uc337xgd.1 uc337xgd.1 
ENSMUST00000361446.1 ENSMUSG00000140816 ENSMUST00000361446.1 ENSMUSG00000140816 (from geneSymbol) uc337xgq.1 uc337xgq.1 
ENSMUST00000361447.1 ENSMUSG00000140817 ENSMUST00000361447.1 ENSMUSG00000140817 (from geneSymbol) uc337xgr.1 uc337xgr.1 
ENSMUST00000361448.1 ENSMUSG00000140818 ENSMUST00000361448.1 ENSMUSG00000140818 (from geneSymbol) uc337xgs.1 uc337xgs.1 
ENSMUST00000361449.1 4921534H16Rik ENSMUST00000361449.1 4921534H16Rik (from geneSymbol) AK133012 uc337xgt.1 uc337xgt.1 
ENSMUST00000361451.1 ENSMUSG00000140819 ENSMUST00000361451.1 ENSMUSG00000140819 (from geneSymbol) uc337xgv.1 uc337xgv.1 
ENSMUST00000361452.1 ENSMUSG00000140820 ENSMUST00000361452.1 ENSMUSG00000140820 (from geneSymbol) uc337xgw.1 uc337xgw.1 
ENSMUST00000361453.1 ENSMUSG00000140821 ENSMUST00000361453.1 ENSMUSG00000140821 (from geneSymbol) uc337xgx.1 uc337xgx.1 
ENSMUST00000361454.1 ENSMUSG00000140822 ENSMUST00000361454.1 ENSMUSG00000140822 (from geneSymbol) uc337xgy.1 uc337xgy.1 
ENSMUST00000361456.1 ENSMUSG00000140823 ENSMUST00000361456.1 ENSMUSG00000140823 (from geneSymbol) uc337xha.1 uc337xha.1 
ENSMUST00000361457.1 ENSMUSG00000140824 ENSMUST00000361457.1 ENSMUSG00000140824 (from geneSymbol) uc337xhb.1 uc337xhb.1 
ENSMUST00000361459.1 ENSMUSG00000140825 ENSMUST00000361459.1 ENSMUSG00000140825 (from geneSymbol) uc337xhd.1 uc337xhd.1 
ENSMUST00000361464.1 ENSMUSG00000140826 ENSMUST00000361464.1 ENSMUSG00000140826 (from geneSymbol) uc337xhi.1 uc337xhi.1 
ENSMUST00000361489.1 ENSMUSG00000140827 ENSMUST00000361489.1 ENSMUSG00000140827 (from geneSymbol) uc337xih.1 uc337xih.1 
ENSMUST00000361490.1 ENSMUSG00000140828 ENSMUST00000361490.1 ENSMUSG00000140828 (from geneSymbol) uc337xii.1 uc337xii.1 
ENSMUST00000361492.1 ENSMUSG00000140829 ENSMUST00000361492.1 ENSMUSG00000140829 (from geneSymbol) uc337xik.1 uc337xik.1 
ENSMUST00000361503.1 ENSMUSG00000140830 ENSMUST00000361503.1 ENSMUSG00000140830 (from geneSymbol) uc337xiv.1 uc337xiv.1 
ENSMUST00000361505.1 ENSMUSG00000140832 ENSMUST00000361505.1 ENSMUSG00000140832 (from geneSymbol) uc337xiw.1 uc337xiw.1 
ENSMUST00000361506.1 ENSMUSG00000140833 ENSMUST00000361506.1 ENSMUSG00000140833 (from geneSymbol) AK132866 uc337xix.1 uc337xix.1 
ENSMUST00000361510.1 ENSMUSG00000140834 ENSMUST00000361510.1 ENSMUSG00000140834 (from geneSymbol) uc337xjb.1 uc337xjb.1 
ENSMUST00000361513.1 ENSMUSG00000140835 ENSMUST00000361513.1 ENSMUSG00000140835 (from geneSymbol) uc337xje.1 uc337xje.1 
ENSMUST00000361515.1 ENSMUSG00000140836 ENSMUST00000361515.1 ENSMUSG00000140836 (from geneSymbol) uc337xjg.1 uc337xjg.1 
ENSMUST00000361517.1 ENSMUSG00000140837 ENSMUST00000361517.1 ENSMUSG00000140837 (from geneSymbol) uc337xji.1 uc337xji.1 
ENSMUST00000361524.1 ENSMUSG00000140838 ENSMUST00000361524.1 ENSMUSG00000140838 (from geneSymbol) uc337xjp.1 uc337xjp.1 
ENSMUST00000361531.1 4930587A21Rik ENSMUST00000361531.1 4930587A21Rik (from geneSymbol) AK016360 uc337xjw.1 uc337xjw.1 
ENSMUST00000361535.1 Gm16793 ENSMUST00000361535.1 Gm16793 (from geneSymbol) AK040224 uc337xka.1 uc337xka.1 
ENSMUST00000361550.1 ENSMUSG00000140839 ENSMUST00000361550.1 ENSMUSG00000140839 (from geneSymbol) uc337xkp.1 uc337xkp.1 
ENSMUST00000361554.1 ENSMUSG00000140840 ENSMUST00000361554.1 ENSMUSG00000140840 (from geneSymbol) uc337xkt.1 uc337xkt.1 
ENSMUST00000361555.1 ENSMUSG00000140841 ENSMUST00000361555.1 ENSMUSG00000140841 (from geneSymbol) uc337xku.1 uc337xku.1 
ENSMUST00000361558.1 ENSMUSG00000140842 ENSMUST00000361558.1 ENSMUSG00000140842 (from geneSymbol) uc337xkx.1 uc337xkx.1 
ENSMUST00000361559.1 ENSMUSG00000140843 ENSMUST00000361559.1 ENSMUSG00000140843 (from geneSymbol) uc337xky.1 uc337xky.1 
ENSMUST00000361562.1 ENSMUSG00000140844 ENSMUST00000361562.1 ENSMUSG00000140844 (from geneSymbol) uc337xlb.1 uc337xlb.1 
ENSMUST00000361564.1 ENSMUSG00000140845 ENSMUST00000361564.1 ENSMUSG00000140845 (from geneSymbol) uc337xld.1 uc337xld.1 
ENSMUST00000361566.1 ENSMUSG00000140847 ENSMUST00000361566.1 ENSMUSG00000140847 (from geneSymbol) uc337xle.1 uc337xle.1 
ENSMUST00000361567.1 ENSMUSG00000140848 ENSMUST00000361567.1 ENSMUSG00000140848 (from geneSymbol) uc337xlf.1 uc337xlf.1 
ENSMUST00000361575.1 ENSMUSG00000140849 ENSMUST00000361575.1 ENSMUSG00000140849 (from geneSymbol) uc337xln.1 uc337xln.1 
ENSMUST00000361576.1 ENSMUSG00000140850 ENSMUST00000361576.1 ENSMUSG00000140850 (from geneSymbol) uc337xlo.1 uc337xlo.1 
ENSMUST00000361577.1 ENSMUSG00000140851 ENSMUST00000361577.1 ENSMUSG00000140851 (from geneSymbol) uc337xlp.1 uc337xlp.1 
ENSMUST00000361578.1 ENSMUSG00000140852 ENSMUST00000361578.1 ENSMUSG00000140852 (from geneSymbol) uc337xlq.1 uc337xlq.1 
ENSMUST00000361579.1 Gm27223 ENSMUST00000361579.1 Gm27223 (from geneSymbol) uc337xlr.1 uc337xlr.1 
ENSMUST00000361600.1 Gm5547 ENSMUST00000361600.1 Gm5547 (from geneSymbol) AK138691 uc337xmm.1 uc337xmm.1 
ENSMUST00000361652.1 ENSMUSG00000140853 ENSMUST00000361652.1 ENSMUSG00000140853 (from geneSymbol) uc337xom.1 uc337xom.1 
ENSMUST00000361655.1 ENSMUSG00000140854 ENSMUST00000361655.1 ENSMUSG00000140854 (from geneSymbol) uc337xop.1 uc337xop.1 
ENSMUST00000361657.1 ENSMUSG00000140855 ENSMUST00000361657.1 ENSMUSG00000140855 (from geneSymbol) uc337xor.1 uc337xor.1 
ENSMUST00000361659.1 ENSMUSG00000140856 ENSMUST00000361659.1 ENSMUSG00000140856 (from geneSymbol) uc337xot.1 uc337xot.1 
ENSMUST00000361660.1 ENSMUSG00000140857 ENSMUST00000361660.1 ENSMUSG00000140857 (from geneSymbol) uc337xou.1 uc337xou.1 
ENSMUST00000361661.1 ENSMUSG00000140858 ENSMUST00000361661.1 ENSMUSG00000140858 (from geneSymbol) uc337xov.1 uc337xov.1 
ENSMUST00000361662.1 ENSMUSG00000140859 ENSMUST00000361662.1 ENSMUSG00000140859 (from geneSymbol) uc337xow.1 uc337xow.1 
ENSMUST00000361663.1 ENSMUSG00000140860 ENSMUST00000361663.1 ENSMUSG00000140860 (from geneSymbol) uc337xox.1 uc337xox.1 
ENSMUST00000361665.1 ENSMUSG00000140861 ENSMUST00000361665.1 ENSMUSG00000140861 (from geneSymbol) uc337xoz.1 uc337xoz.1 
ENSMUST00000361666.1 ENSMUSG00000140862 ENSMUST00000361666.1 ENSMUSG00000140862 (from geneSymbol) uc337xpa.1 uc337xpa.1 
ENSMUST00000361667.1 ENSMUSG00000140863 ENSMUST00000361667.1 ENSMUSG00000140863 (from geneSymbol) uc337xpb.1 uc337xpb.1 
ENSMUST00000361669.1 ENSMUSG00000140864 ENSMUST00000361669.1 ENSMUSG00000140864 (from geneSymbol) uc337xpd.1 uc337xpd.1 
ENSMUST00000361672.1 ENSMUSG00000140865 ENSMUST00000361672.1 ENSMUSG00000140865 (from geneSymbol) uc337xpg.1 uc337xpg.1 
ENSMUST00000361673.1 ENSMUSG00000140866 ENSMUST00000361673.1 ENSMUSG00000140866 (from geneSymbol) uc337xph.1 uc337xph.1 
ENSMUST00000361674.1 ENSMUSG00000140867 ENSMUST00000361674.1 ENSMUSG00000140867 (from geneSymbol) uc337xpi.1 uc337xpi.1 
ENSMUST00000361675.1 ENSMUSG00000140868 ENSMUST00000361675.1 ENSMUSG00000140868 (from geneSymbol) uc337xpj.1 uc337xpj.1 
ENSMUST00000361677.1 ENSMUSG00000140869 ENSMUST00000361677.1 ENSMUSG00000140869 (from geneSymbol) uc337xpl.1 uc337xpl.1 
ENSMUST00000361678.1 ENSMUSG00000140870 ENSMUST00000361678.1 ENSMUSG00000140870 (from geneSymbol) uc337xpm.1 uc337xpm.1 
ENSMUST00000361679.1 ENSMUSG00000140871 ENSMUST00000361679.1 ENSMUSG00000140871 (from geneSymbol) uc337xpn.1 uc337xpn.1 
ENSMUST00000361680.1 ENSMUSG00000140872 ENSMUST00000361680.1 ENSMUSG00000140872 (from geneSymbol) uc337xpo.1 uc337xpo.1 
ENSMUST00000361681.1 ENSMUSG00000140873 ENSMUST00000361681.1 ENSMUSG00000140873 (from geneSymbol) uc337xpp.1 uc337xpp.1 
ENSMUST00000361683.1 Gm35551 ENSMUST00000361683.1 Gm35551 (from geneSymbol) AK039852 uc337xpr.1 uc337xpr.1 
ENSMUST00000361703.1 ENSMUSG00000140874 ENSMUST00000361703.1 ENSMUSG00000140874 (from geneSymbol) uc337xql.1 uc337xql.1 
ENSMUST00000361708.1 ENSMUSG00000140875 ENSMUST00000361708.1 ENSMUSG00000140875 (from geneSymbol) uc337xqq.1 uc337xqq.1 
ENSMUST00000361710.1 ENSMUSG00000140876 ENSMUST00000361710.1 ENSMUSG00000140876 (from geneSymbol) uc337xqs.1 uc337xqs.1 
ENSMUST00000361727.1 ENSMUSG00000140877 ENSMUST00000361727.1 ENSMUSG00000140877 (from geneSymbol) uc337xrj.1 uc337xrj.1 
ENSMUST00000361729.1 ENSMUSG00000140878 ENSMUST00000361729.1 ENSMUSG00000140878 (from geneSymbol) uc337xrl.1 uc337xrl.1 
ENSMUST00000361730.1 ENSMUSG00000140879 ENSMUST00000361730.1 ENSMUSG00000140879 (from geneSymbol) AK133627 uc337xrm.1 uc337xrm.1 
ENSMUST00000361733.1 Gm33929 ENSMUST00000361733.1 Gm33929 (from geneSymbol) uc337xrp.1 uc337xrp.1 
ENSMUST00000361736.1 ENSMUSG00000140880 ENSMUST00000361736.1 ENSMUSG00000140880 (from geneSymbol) uc337xrs.1 uc337xrs.1 
ENSMUST00000361737.1 ENSMUSG00000140881 ENSMUST00000361737.1 ENSMUSG00000140881 (from geneSymbol) uc337xrt.1 uc337xrt.1 
ENSMUST00000361738.1 ENSMUSG00000140882 ENSMUST00000361738.1 ENSMUSG00000140882 (from geneSymbol) uc337xru.1 uc337xru.1 
ENSMUST00000361740.1 4930558F17Rik ENSMUST00000361740.1 4930558F17Rik (from geneSymbol) AK016172 uc337xrw.1 uc337xrw.1 
ENSMUST00000361754.1 ENSMUSG00000140883 ENSMUST00000361754.1 ENSMUSG00000140883 (from geneSymbol) uc337xsk.1 uc337xsk.1 
ENSMUST00000361755.1 ENSMUSG00000140884 ENSMUST00000361755.1 ENSMUSG00000140884 (from geneSymbol) uc337xsl.1 uc337xsl.1 
ENSMUST00000361756.1 ENSMUSG00000140885 ENSMUST00000361756.1 ENSMUSG00000140885 (from geneSymbol) uc337xsm.1 uc337xsm.1 
ENSMUST00000361758.1 ENSMUSG00000140886 ENSMUST00000361758.1 ENSMUSG00000140886 (from geneSymbol) uc337xso.1 uc337xso.1 
ENSMUST00000361760.1 Gm29296 ENSMUST00000361760.1 Gm29296 (from geneSymbol) uc337xsq.1 uc337xsq.1 
ENSMUST00000361769.1 ENSMUSG00000140888 ENSMUST00000361769.1 ENSMUSG00000140888 (from geneSymbol) uc337xsy.1 uc337xsy.1 
ENSMUST00000361773.1 ENSMUSG00000140889 ENSMUST00000361773.1 ENSMUSG00000140889 (from geneSymbol) uc337xtc.1 uc337xtc.1 
ENSMUST00000361780.1 ENSMUSG00000140890 ENSMUST00000361780.1 ENSMUSG00000140890 (from geneSymbol) uc337xtj.1 uc337xtj.1 
ENSMUST00000361781.1 ENSMUSG00000140891 ENSMUST00000361781.1 ENSMUSG00000140891 (from geneSymbol) uc337xtk.1 uc337xtk.1 
ENSMUST00000361782.1 ENSMUSG00000140892 ENSMUST00000361782.1 ENSMUSG00000140892 (from geneSymbol) uc337xtl.1 uc337xtl.1 
ENSMUST00000361783.1 ENSMUSG00000140893 ENSMUST00000361783.1 ENSMUSG00000140893 (from geneSymbol) uc337xtm.1 uc337xtm.1 
ENSMUST00000361791.1 Gm27175 ENSMUST00000361791.1 Gm27175 (from geneSymbol) uc337xtu.1 uc337xtu.1 
ENSMUST00000361803.1 ENSMUSG00000140894 ENSMUST00000361803.1 ENSMUSG00000140894 (from geneSymbol) uc337xug.1 uc337xug.1 
ENSMUST00000361809.1 ENSMUSG00000140895 ENSMUST00000361809.1 ENSMUSG00000140895 (from geneSymbol) uc337xum.1 uc337xum.1 
ENSMUST00000361811.1 ENSMUSG00000140896 ENSMUST00000361811.1 ENSMUSG00000140896 (from geneSymbol) uc337xuo.1 uc337xuo.1 
ENSMUST00000361812.1 ENSMUSG00000140897 ENSMUST00000361812.1 ENSMUSG00000140897 (from geneSymbol) uc337xup.1 uc337xup.1 
ENSMUST00000361814.1 Gm36737 ENSMUST00000361814.1 Gm36737 (from geneSymbol) uc337xur.1 uc337xur.1 
ENSMUST00000361819.1 ENSMUSG00000140898 ENSMUST00000361819.1 ENSMUSG00000140898 (from geneSymbol) uc337xuw.1 uc337xuw.1 
ENSMUST00000361820.1 ENSMUSG00000140899 ENSMUST00000361820.1 ENSMUSG00000140899 (from geneSymbol) uc337xux.1 uc337xux.1 
ENSMUST00000361821.1 ENSMUSG00000140900 ENSMUST00000361821.1 ENSMUSG00000140900 (from geneSymbol) uc337xuy.1 uc337xuy.1 
ENSMUST00000361822.1 ENSMUSG00000140901 ENSMUST00000361822.1 ENSMUSG00000140901 (from geneSymbol) uc337xuz.1 uc337xuz.1 
ENSMUST00000361823.1 ENSMUSG00000140902 ENSMUST00000361823.1 ENSMUSG00000140902 (from geneSymbol) uc337xva.1 uc337xva.1 
ENSMUST00000361824.1 ENSMUSG00000140903 ENSMUST00000361824.1 ENSMUSG00000140903 (from geneSymbol) uc337xvb.1 uc337xvb.1 
ENSMUST00000361829.1 ENSMUSG00000140905 ENSMUST00000361829.1 ENSMUSG00000140905 (from geneSymbol) uc337xvd.1 uc337xvd.1 
ENSMUST00000361832.1 ENSMUSG00000140906 ENSMUST00000361832.1 ENSMUSG00000140906 (from geneSymbol) uc337xvg.1 uc337xvg.1 
ENSMUST00000361837.1 ENSMUSG00000140907 ENSMUST00000361837.1 ENSMUSG00000140907 (from geneSymbol) uc337xvl.1 uc337xvl.1 
ENSMUST00000361849.1 ENSMUSG00000140908 ENSMUST00000361849.1 ENSMUSG00000140908 (from geneSymbol) uc337xvx.1 uc337xvx.1 
ENSMUST00000361850.1 ENSMUSG00000140909 ENSMUST00000361850.1 ENSMUSG00000140909 (from geneSymbol) uc337xvy.1 uc337xvy.1 
ENSMUST00000361853.1 Gm9805 ENSMUST00000361853.1 Gm9805 (from geneSymbol) uc337xwb.1 uc337xwb.1 
ENSMUST00000361859.1 ENSMUSG00000140911 ENSMUST00000361859.1 ENSMUSG00000140911 (from geneSymbol) uc337xwh.1 uc337xwh.1 
ENSMUST00000361863.1 ENSMUSG00000140912 ENSMUST00000361863.1 ENSMUSG00000140912 (from geneSymbol) uc337xwl.1 uc337xwl.1 
ENSMUST00000361906.1 ENSMUSG00000140913 ENSMUST00000361906.1 ENSMUSG00000140913 (from geneSymbol) uc337xyc.1 uc337xyc.1 
ENSMUST00000361940.1 ENSMUSG00000140914 ENSMUST00000361940.1 ENSMUSG00000140914 (from geneSymbol) uc337xzf.1 uc337xzf.1 
ENSMUST00000361941.1 Gm49967 ENSMUST00000361941.1 Gm49967 (from geneSymbol) uc337xzg.1 uc337xzg.1 
ENSMUST00000361949.1 ENSMUSG00000140915 ENSMUST00000361949.1 ENSMUSG00000140915 (from geneSymbol) uc337xzo.1 uc337xzo.1 
ENSMUST00000361955.1 Gm56652 ENSMUST00000361955.1 Gm56652 (from geneSymbol) AK052812 uc337xzu.1 uc337xzu.1 
ENSMUST00000361963.1 ENSMUSG00000140916 ENSMUST00000361963.1 ENSMUSG00000140916 (from geneSymbol) uc337yac.1 uc337yac.1 
ENSMUST00000361966.1 Gm40117 ENSMUST00000361966.1 Gm40117 (from geneSymbol) uc337yaf.1 uc337yaf.1 
ENSMUST00000362009.1 Gm56822 ENSMUST00000362009.1 RIKEN cDNA 4922502B01 gene (from RefSeq NR_151498.1) NR_151498 uc337ybw.1 uc337ybw.1 
ENSMUST00000362022.1 ENSMUSG00000140917 ENSMUST00000362022.1 ENSMUSG00000140917 (from geneSymbol) uc337ycj.1 uc337ycj.1 
ENSMUST00000362024.1 ENSMUSG00000140918 ENSMUST00000362024.1 ENSMUSG00000140918 (from geneSymbol) uc337ycl.1 uc337ycl.1 
ENSMUST00000362036.1 ENSMUSG00000140919 ENSMUST00000362036.1 ENSMUSG00000140919 (from geneSymbol) uc337ycx.1 uc337ycx.1 
ENSMUST00000362037.1 ENSMUSG00000140920 ENSMUST00000362037.1 ENSMUSG00000140920 (from geneSymbol) uc337ycy.1 uc337ycy.1 
ENSMUST00000362039.1 ENSMUSG00000140921 ENSMUST00000362039.1 ENSMUSG00000140921 (from geneSymbol) uc337yda.1 uc337yda.1 
ENSMUST00000362040.1 ENSMUSG00000140922 ENSMUST00000362040.1 ENSMUSG00000140922 (from geneSymbol) uc337ydb.1 uc337ydb.1 
ENSMUST00000362041.1 ENSMUSG00000140923 ENSMUST00000362041.1 ENSMUSG00000140923 (from geneSymbol) uc337ydc.1 uc337ydc.1 
ENSMUST00000362042.1 1700109G15Rik ENSMUST00000362042.1 1700109G15Rik (from geneSymbol) AK018946 uc337ydd.1 uc337ydd.1 
ENSMUST00000362055.1 Gm32552 ENSMUST00000362055.1 Gm32552 (from geneSymbol) uc337ydq.1 uc337ydq.1 
ENSMUST00000362059.1 2210406O10Rik ENSMUST00000362059.1 2210406O10Rik (from geneSymbol) AK144870 uc337ydu.1 uc337ydu.1 
ENSMUST00000362071.1 ENSMUSG00000140924 ENSMUST00000362071.1 ENSMUSG00000140924 (from geneSymbol) uc337yeg.1 uc337yeg.1 
ENSMUST00000362072.1 ENSMUSG00000140925 ENSMUST00000362072.1 ENSMUSG00000140925 (from geneSymbol) uc337yeh.1 uc337yeh.1 
ENSMUST00000362073.1 ENSMUSG00000140926 ENSMUST00000362073.1 ENSMUSG00000140926 (from geneSymbol) uc337yei.1 uc337yei.1 
ENSMUST00000362084.1 ENSMUSG00000140927 ENSMUST00000362084.1 ENSMUSG00000140927 (from geneSymbol) uc337yet.1 uc337yet.1 
ENSMUST00000362137.1 ENSMUSG00000140928 ENSMUST00000362137.1 ENSMUSG00000140928 (from geneSymbol) uc337ygu.1 uc337ygu.1 
ENSMUST00000362138.1 ENSMUSG00000140929 ENSMUST00000362138.1 ENSMUSG00000140929 (from geneSymbol) uc337ygv.1 uc337ygv.1 
ENSMUST00000362139.1 ENSMUSG00000140930 ENSMUST00000362139.1 ENSMUSG00000140930 (from geneSymbol) uc337ygw.1 uc337ygw.1 
ENSMUST00000362140.1 ENSMUSG00000140931 ENSMUST00000362140.1 ENSMUSG00000140931 (from geneSymbol) uc337ygx.1 uc337ygx.1 
ENSMUST00000362141.1 ENSMUSG00000140932 ENSMUST00000362141.1 ENSMUSG00000140932 (from geneSymbol) uc337ygy.1 uc337ygy.1 
ENSMUST00000362144.1 Gm56897 ENSMUST00000362144.1 Gm56897 (from geneSymbol) uc337yhb.1 uc337yhb.1 
ENSMUST00000362147.1 ENSMUSG00000140933 ENSMUST00000362147.1 ENSMUSG00000140933 (from geneSymbol) uc337yhe.1 uc337yhe.1 
ENSMUST00000362148.1 ENSMUSG00000140934 ENSMUST00000362148.1 ENSMUSG00000140934 (from geneSymbol) uc337yhf.1 uc337yhf.1 
ENSMUST00000362151.1 ENSMUSG00000140935 ENSMUST00000362151.1 ENSMUSG00000140935 (from geneSymbol) uc337yhi.1 uc337yhi.1 
ENSMUST00000362153.1 ENSMUSG00000140936 ENSMUST00000362153.1 ENSMUSG00000140936 (from geneSymbol) uc337yhk.1 uc337yhk.1 
ENSMUST00000362154.1 Gm31129 ENSMUST00000362154.1 Gm31129 (from geneSymbol) uc337yhl.1 uc337yhl.1 
ENSMUST00000362160.1 ENSMUSG00000140938 ENSMUST00000362160.1 ENSMUSG00000140938 (from geneSymbol) uc337yhr.1 uc337yhr.1 
ENSMUST00000362162.1 ENSMUSG00000140939 ENSMUST00000362162.1 ENSMUSG00000140939 (from geneSymbol) uc337yht.1 uc337yht.1 
ENSMUST00000362165.1 ENSMUSG00000140940 ENSMUST00000362165.1 ENSMUSG00000140940 (from geneSymbol) uc337yhw.1 uc337yhw.1 
ENSMUST00000362166.1 ENSMUSG00000140941 ENSMUST00000362166.1 ENSMUSG00000140941 (from geneSymbol) uc337yhx.1 uc337yhx.1 
ENSMUST00000362167.1 ENSMUSG00000140942 ENSMUST00000362167.1 ENSMUSG00000140942 (from geneSymbol) uc337yhy.1 uc337yhy.1 
ENSMUST00000362168.1 ENSMUSG00000140943 ENSMUST00000362168.1 ENSMUSG00000140943 (from geneSymbol) uc337yhz.1 uc337yhz.1 
ENSMUST00000362170.1 ENSMUSG00000140944 ENSMUST00000362170.1 ENSMUSG00000140944 (from geneSymbol) uc337yib.1 uc337yib.1 
ENSMUST00000362177.1 ENSMUSG00000140945 ENSMUST00000362177.1 ENSMUSG00000140945 (from geneSymbol) uc337yii.1 uc337yii.1 
ENSMUST00000362178.1 ENSMUSG00000140946 ENSMUST00000362178.1 ENSMUSG00000140946 (from geneSymbol) uc337yij.1 uc337yij.1 
ENSMUST00000362180.1 Gm40604 ENSMUST00000362180.1 Gm40604 (from geneSymbol) uc337yik.1 uc337yik.1 
ENSMUST00000362223.1 ENSMUSG00000140948 ENSMUST00000362223.1 ENSMUSG00000140948 (from geneSymbol) uc337ykb.1 uc337ykb.1 
ENSMUST00000362234.1 ENSMUSG00000140949 ENSMUST00000362234.1 ENSMUSG00000140949 (from geneSymbol) uc337ykm.1 uc337ykm.1 
ENSMUST00000362235.1 ENSMUSG00000140950 ENSMUST00000362235.1 ENSMUSG00000140950 (from geneSymbol) uc337ykn.1 uc337ykn.1 
ENSMUST00000362238.1 ENSMUSG00000140951 ENSMUST00000362238.1 ENSMUSG00000140951 (from geneSymbol) uc337ykq.1 uc337ykq.1 
ENSMUST00000362246.1 ENSMUSG00000140952 ENSMUST00000362246.1 ENSMUSG00000140952 (from geneSymbol) uc337yky.1 uc337yky.1 
ENSMUST00000362261.1 ENSMUSG00000140954 ENSMUST00000362261.1 ENSMUSG00000140954 (from geneSymbol) uc337ylm.1 uc337ylm.1 
ENSMUST00000362263.1 ENSMUSG00000140955 ENSMUST00000362263.1 ENSMUSG00000140955 (from geneSymbol) uc337ylo.1 uc337ylo.1 
ENSMUST00000362264.1 ENSMUSG00000140956 ENSMUST00000362264.1 ENSMUSG00000140956 (from geneSymbol) uc337ylp.1 uc337ylp.1 
ENSMUST00000362265.1 ENSMUSG00000140957 ENSMUST00000362265.1 ENSMUSG00000140957 (from geneSymbol) uc337ylq.1 uc337ylq.1 
ENSMUST00000362268.1 ENSMUSG00000140958 ENSMUST00000362268.1 ENSMUSG00000140958 (from geneSymbol) uc337ylt.1 uc337ylt.1 
ENSMUST00000362270.1 Gm12930 ENSMUST00000362270.1 Gm12930 (from geneSymbol) uc337ylv.1 uc337ylv.1 
ENSMUST00000362287.1 ENSMUSG00000140959 ENSMUST00000362287.1 ENSMUSG00000140959 (from geneSymbol) uc337ymm.1 uc337ymm.1 
ENSMUST00000362290.1 ENSMUSG00000140961 ENSMUST00000362290.1 ENSMUSG00000140961 (from geneSymbol) uc337ymo.1 uc337ymo.1 
ENSMUST00000362293.1 ENSMUSG00000140962 ENSMUST00000362293.1 ENSMUSG00000140962 (from geneSymbol) uc337ymr.1 uc337ymr.1 
ENSMUST00000362294.1 ENSMUSG00000140963 ENSMUST00000362294.1 ENSMUSG00000140963 (from geneSymbol) uc337yms.1 uc337yms.1 
ENSMUST00000362297.1 ENSMUSG00000140964 ENSMUST00000362297.1 ENSMUSG00000140964 (from geneSymbol) uc337ymv.1 uc337ymv.1 
ENSMUST00000362323.1 ENSMUSG00000140965 ENSMUST00000362323.1 ENSMUSG00000140965 (from geneSymbol) uc337ynv.1 uc337ynv.1 
ENSMUST00000362325.1 ENSMUSG00000140966 ENSMUST00000362325.1 ENSMUSG00000140966 (from geneSymbol) uc337ynx.1 uc337ynx.1 
ENSMUST00000362326.1 ENSMUSG00000140967 ENSMUST00000362326.1 ENSMUSG00000140967 (from geneSymbol) uc337yny.1 uc337yny.1 
ENSMUST00000362327.1 ENSMUSG00000140968 ENSMUST00000362327.1 ENSMUSG00000140968 (from geneSymbol) uc337ynz.1 uc337ynz.1 
ENSMUST00000362329.1 ENSMUSG00000140969 ENSMUST00000362329.1 ENSMUSG00000140969 (from geneSymbol) uc337yob.1 uc337yob.1 
ENSMUST00000362342.1 ENSMUSG00000140970 ENSMUST00000362342.1 ENSMUSG00000140970 (from geneSymbol) uc337yoo.1 uc337yoo.1 
ENSMUST00000362347.1 ENSMUSG00000140971 ENSMUST00000362347.1 ENSMUSG00000140971 (from geneSymbol) AK133775 uc337yot.1 uc337yot.1 
ENSMUST00000362349.1 ENSMUSG00000140972 ENSMUST00000362349.1 ENSMUSG00000140972 (from geneSymbol) uc337yov.1 uc337yov.1 
ENSMUST00000362350.1 ENSMUSG00000140973 ENSMUST00000362350.1 ENSMUSG00000140973 (from geneSymbol) uc337yow.1 uc337yow.1 
ENSMUST00000362351.1 ENSMUSG00000140974 ENSMUST00000362351.1 ENSMUSG00000140974 (from geneSymbol) uc337yox.1 uc337yox.1 
ENSMUST00000362352.1 ENSMUSG00000140975 ENSMUST00000362352.1 ENSMUSG00000140975 (from geneSymbol) uc337yoy.1 uc337yoy.1 
ENSMUST00000362353.1 ENSMUSG00000140976 ENSMUST00000362353.1 ENSMUSG00000140976 (from geneSymbol) uc337yoz.1 uc337yoz.1 
ENSMUST00000362355.1 ENSMUSG00000140977 ENSMUST00000362355.1 ENSMUSG00000140977 (from geneSymbol) uc337ypb.1 uc337ypb.1 
ENSMUST00000362357.1 ENSMUSG00000140978 ENSMUST00000362357.1 ENSMUSG00000140978 (from geneSymbol) uc337ypd.1 uc337ypd.1 
ENSMUST00000362359.1 Gm16938 ENSMUST00000362359.1 Gm16938 (from geneSymbol) BC144933 uc337ypf.1 uc337ypf.1 
ENSMUST00000362363.1 ENSMUSG00000140979 ENSMUST00000362363.1 ENSMUSG00000140979 (from geneSymbol) uc337ypj.1 uc337ypj.1 
ENSMUST00000362364.1 ENSMUSG00000140980 ENSMUST00000362364.1 ENSMUSG00000140980 (from geneSymbol) uc337ypk.1 uc337ypk.1 
ENSMUST00000362372.1 ENSMUSG00000140981 ENSMUST00000362372.1 ENSMUSG00000140981 (from geneSymbol) uc337yps.1 uc337yps.1 
ENSMUST00000362378.1 Gm30487 ENSMUST00000362378.1 Gm30487 (from geneSymbol) uc337ypy.1 uc337ypy.1 
ENSMUST00000362397.1 ENSMUSG00000140982 ENSMUST00000362397.1 ENSMUSG00000140982 (from geneSymbol) uc337yqr.1 uc337yqr.1 
ENSMUST00000362398.1 ENSMUSG00000140983 ENSMUST00000362398.1 ENSMUSG00000140983 (from geneSymbol) uc337yqs.1 uc337yqs.1 
ENSMUST00000362399.1 ENSMUSG00000140984 ENSMUST00000362399.1 ENSMUSG00000140984 (from geneSymbol) uc337yqt.1 uc337yqt.1 
ENSMUST00000362401.1 ENSMUSG00000140985 ENSMUST00000362401.1 ENSMUSG00000140985 (from geneSymbol) uc337yqv.1 uc337yqv.1 
ENSMUST00000362403.1 Gm29018 ENSMUST00000362403.1 Gm29018 (from geneSymbol) uc337yqx.1 uc337yqx.1 
ENSMUST00000362406.1 ENSMUSG00000140986 ENSMUST00000362406.1 ENSMUSG00000140986 (from geneSymbol) uc337yra.1 uc337yra.1 
ENSMUST00000362414.1 ENSMUSG00000140987 ENSMUST00000362414.1 ENSMUSG00000140987 (from geneSymbol) uc337yri.1 uc337yri.1 
ENSMUST00000362415.1 ENSMUSG00000140988 ENSMUST00000362415.1 ENSMUSG00000140988 (from geneSymbol) uc337yrj.1 uc337yrj.1 
ENSMUST00000362418.1 ENSMUSG00000140989 ENSMUST00000362418.1 ENSMUSG00000140989 (from geneSymbol) uc337yrm.1 uc337yrm.1 
ENSMUST00000362419.1 1700099I09Rik ENSMUST00000362419.1 1700099I09Rik (from geneSymbol) AK007100 uc337yrn.1 uc337yrn.1 
ENSMUST00000362442.1 ENSMUSG00000140990 ENSMUST00000362442.1 ENSMUSG00000140990 (from geneSymbol) uc337ysk.1 uc337ysk.1 
ENSMUST00000362443.1 ENSMUSG00000140991 ENSMUST00000362443.1 ENSMUSG00000140991 (from geneSymbol) uc337ysl.1 uc337ysl.1 
ENSMUST00000362449.1 ENSMUSG00000140992 ENSMUST00000362449.1 ENSMUSG00000140992 (from geneSymbol) uc337ysr.1 uc337ysr.1 
ENSMUST00000362450.1 ENSMUSG00000140993 ENSMUST00000362450.1 ENSMUSG00000140993 (from geneSymbol) uc337yss.1 uc337yss.1 
ENSMUST00000362455.1 ENSMUSG00000140994 ENSMUST00000362455.1 ENSMUSG00000140994 (from geneSymbol) uc337ysx.1 uc337ysx.1 
ENSMUST00000362456.1 Gm13807 ENSMUST00000362456.1 Gm13807 (from geneSymbol) AK029608 uc337ysy.1 uc337ysy.1 
ENSMUST00000362465.1 ENSMUSG00000140995 ENSMUST00000362465.1 ENSMUSG00000140995 (from geneSymbol) uc337yth.1 uc337yth.1 
ENSMUST00000362466.1 ENSMUSG00000140996 ENSMUST00000362466.1 ENSMUSG00000140996 (from geneSymbol) uc337yti.1 uc337yti.1 
ENSMUST00000362468.1 ENSMUSG00000140997 ENSMUST00000362468.1 ENSMUSG00000140997 (from geneSymbol) uc337ytk.1 uc337ytk.1 
ENSMUST00000362470.1 ENSMUSG00000140998 ENSMUST00000362470.1 ENSMUSG00000140998 (from geneSymbol) uc337ytm.1 uc337ytm.1 
ENSMUST00000362472.1 ENSMUSG00000140999 ENSMUST00000362472.1 ENSMUSG00000140999 (from geneSymbol) uc337yto.1 uc337yto.1 
ENSMUST00000362476.1 ENSMUSG00000141000 ENSMUST00000362476.1 ENSMUSG00000141000 (from geneSymbol) uc337yts.1 uc337yts.1 
ENSMUST00000362490.1 ENSMUSG00000141002 ENSMUST00000362490.1 ENSMUSG00000141002 (from geneSymbol) uc337yuf.1 uc337yuf.1 
ENSMUST00000362499.1 ENSMUSG00000141003 ENSMUST00000362499.1 ENSMUSG00000141003 (from geneSymbol) uc337yuo.1 uc337yuo.1 
ENSMUST00000362501.1 ENSMUSG00000141004 ENSMUST00000362501.1 ENSMUSG00000141004 (from geneSymbol) uc337yuq.1 uc337yuq.1 
ENSMUST00000362502.1 ENSMUSG00000141005 ENSMUST00000362502.1 ENSMUSG00000141005 (from geneSymbol) uc337yur.1 uc337yur.1 
ENSMUST00000362503.1 ENSMUSG00000141006 ENSMUST00000362503.1 ENSMUSG00000141006 (from geneSymbol) uc337yus.1 uc337yus.1 
ENSMUST00000362507.1 ENSMUSG00000141007 ENSMUST00000362507.1 ENSMUSG00000141007 (from geneSymbol) uc337yuw.1 uc337yuw.1 
ENSMUST00000362508.1 ENSMUSG00000141008 ENSMUST00000362508.1 ENSMUSG00000141008 (from geneSymbol) uc337yux.1 uc337yux.1 
ENSMUST00000362510.1 ENSMUSG00000141009 ENSMUST00000362510.1 ENSMUSG00000141009 (from geneSymbol) uc337yuz.1 uc337yuz.1 
ENSMUST00000362511.1 ENSMUSG00000141010 ENSMUST00000362511.1 ENSMUSG00000141010 (from geneSymbol) uc337yva.1 uc337yva.1 
ENSMUST00000362513.1 Gm15917 ENSMUST00000362513.1 Gm15917 (from geneSymbol) uc337yvc.1 uc337yvc.1 
ENSMUST00000362519.1 ENSMUSG00000141011 ENSMUST00000362519.1 ENSMUSG00000141011 (from geneSymbol) uc337yvi.1 uc337yvi.1 
ENSMUST00000362523.1 ENSMUSG00000141012 ENSMUST00000362523.1 ENSMUSG00000141012 (from geneSymbol) uc337yvl.1 uc337yvl.1 
ENSMUST00000362527.1 4930473A02Rik ENSMUST00000362527.1 4930473A02Rik (from geneSymbol) AK015562 uc337yvp.1 uc337yvp.1 
ENSMUST00000362531.1 ENSMUSG00000141013 ENSMUST00000362531.1 ENSMUSG00000141013 (from geneSymbol) AK054523 uc337yvt.1 uc337yvt.1 
ENSMUST00000362533.1 ENSMUSG00000141014 ENSMUST00000362533.1 ENSMUSG00000141014 (from geneSymbol) uc337yvv.1 uc337yvv.1 
ENSMUST00000362544.1 ENSMUSG00000141015 ENSMUST00000362544.1 ENSMUSG00000141015 (from geneSymbol) uc337ywg.1 uc337ywg.1 
ENSMUST00000362545.1 ENSMUSG00000141016 ENSMUST00000362545.1 ENSMUSG00000141016 (from geneSymbol) uc337ywh.1 uc337ywh.1 
ENSMUST00000362547.1 ENSMUSG00000141017 ENSMUST00000362547.1 ENSMUSG00000141017 (from geneSymbol) uc337ywj.1 uc337ywj.1 
ENSMUST00000362563.1 ENSMUSG00000141018 ENSMUST00000362563.1 ENSMUSG00000141018 (from geneSymbol) uc337ywz.1 uc337ywz.1 
ENSMUST00000362567.1 ENSMUSG00000141019 ENSMUST00000362567.1 ENSMUSG00000141019 (from geneSymbol) uc337yxd.1 uc337yxd.1 
ENSMUST00000362568.1 ENSMUSG00000141020 ENSMUST00000362568.1 ENSMUSG00000141020 (from geneSymbol) uc337yxe.1 uc337yxe.1 
ENSMUST00000362570.1 ENSMUSG00000141021 ENSMUST00000362570.1 ENSMUSG00000141021 (from geneSymbol) uc337yxg.1 uc337yxg.1 
ENSMUST00000362577.1 4930594A02Rik ENSMUST00000362577.1 4930594A02Rik (from geneSymbol) uc337yxn.1 uc337yxn.1 
ENSMUST00000362583.1 ENSMUSG00000141022 ENSMUST00000362583.1 ENSMUSG00000141022 (from geneSymbol) uc337yxt.1 uc337yxt.1 
ENSMUST00000362584.1 ENSMUSG00000141023 ENSMUST00000362584.1 ENSMUSG00000141023 (from geneSymbol) uc337yxu.1 uc337yxu.1 
ENSMUST00000362588.1 ENSMUSG00000141024 ENSMUST00000362588.1 ENSMUSG00000141024 (from geneSymbol) uc337yxy.1 uc337yxy.1 
ENSMUST00000362602.1 Gm11691 ENSMUST00000362602.1 Gm11691 (from geneSymbol) AK132953 uc337yym.1 uc337yym.1 
ENSMUST00000362608.1 ENSMUSG00000141025 ENSMUST00000362608.1 ENSMUSG00000141025 (from geneSymbol) uc337yys.1 uc337yys.1 
ENSMUST00000362616.1 ENSMUSG00000141026 ENSMUST00000362616.1 ENSMUSG00000141026 (from geneSymbol) uc337yza.1 uc337yza.1 
ENSMUST00000362620.1 ENSMUSG00000141027 ENSMUST00000362620.1 ENSMUSG00000141027 (from geneSymbol) uc337yze.1 uc337yze.1 
ENSMUST00000362624.1 ENSMUSG00000141028 ENSMUST00000362624.1 uncharacterized LOC115487221 (from RefSeq NR_165179.1) NR_165179 uc337yzi.1 uc337yzi.1 
ENSMUST00000362628.1 Gm20234 ENSMUST00000362628.1 Gm20234 (from geneSymbol) AY261803 uc337yzm.1 uc337yzm.1 
ENSMUST00000362630.1 ENSMUSG00000141029 ENSMUST00000362630.1 ENSMUSG00000141029 (from geneSymbol) uc337yzo.1 uc337yzo.1 
ENSMUST00000362631.1 Gm44930 ENSMUST00000362631.1 Gm44930 (from geneSymbol) AK053040 uc337yzp.1 uc337yzp.1 
ENSMUST00000362638.1 ENSMUSG00000141030 ENSMUST00000362638.1 ENSMUSG00000141030 (from geneSymbol) uc337yzw.1 uc337yzw.1 
ENSMUST00000362648.1 Mexis ENSMUST00000362648.1 Mexis (from geneSymbol) AK144542 uc337zag.1 uc337zag.1 
ENSMUST00000362681.1 ENSMUSG00000141031 ENSMUST00000362681.1 ENSMUSG00000141031 (from geneSymbol) uc337zbn.1 uc337zbn.1 
ENSMUST00000362683.1 ENSMUSG00000141032 ENSMUST00000362683.1 ENSMUSG00000141032 (from geneSymbol) AK133319 uc337zbp.1 uc337zbp.1 
ENSMUST00000362685.1 ENSMUSG00000141033 ENSMUST00000362685.1 ENSMUSG00000141033 (from geneSymbol) uc337zbr.1 uc337zbr.1 
ENSMUST00000362687.1 ENSMUSG00000141034 ENSMUST00000362687.1 ENSMUSG00000141034 (from geneSymbol) uc337zbt.1 uc337zbt.1 
ENSMUST00000362692.1 Gm33308 ENSMUST00000362692.1 Gm33308 (from geneSymbol) uc337zby.1 uc337zby.1 
ENSMUST00000362694.1 ENSMUSG00000141035 ENSMUST00000362694.1 ENSMUSG00000141035 (from geneSymbol) uc337zca.1 uc337zca.1 
ENSMUST00000362697.1 ENSMUSG00000141036 ENSMUST00000362697.1 ENSMUSG00000141036 (from geneSymbol) uc337zcd.1 uc337zcd.1 
ENSMUST00000362699.1 ENSMUSG00000141037 ENSMUST00000362699.1 ENSMUSG00000141037 (from geneSymbol) uc337zcf.1 uc337zcf.1 
ENSMUST00000362702.1 ENSMUSG00000141039 ENSMUST00000362702.1 ENSMUSG00000141039 (from geneSymbol) uc337zcg.1 uc337zcg.1 
ENSMUST00000362703.1 ENSMUSG00000141040 ENSMUST00000362703.1 ENSMUSG00000141040 (from geneSymbol) uc337zch.1 uc337zch.1 
ENSMUST00000362705.1 ENSMUSG00000141041 ENSMUST00000362705.1 ENSMUSG00000141041 (from geneSymbol) uc337zcj.1 uc337zcj.1 
ENSMUST00000362706.1 ENSMUSG00000141042 ENSMUST00000362706.1 ENSMUSG00000141042 (from geneSymbol) uc337zck.1 uc337zck.1 
ENSMUST00000362707.1 ENSMUSG00000141043 ENSMUST00000362707.1 ENSMUSG00000141043 (from geneSymbol) uc337zcl.1 uc337zcl.1 
ENSMUST00000362708.1 ENSMUSG00000141044 ENSMUST00000362708.1 ENSMUSG00000141044 (from geneSymbol) uc337zcm.1 uc337zcm.1 
ENSMUST00000362709.1 ENSMUSG00000141045 ENSMUST00000362709.1 ENSMUSG00000141045 (from geneSymbol) uc337zcn.1 uc337zcn.1 
ENSMUST00000362713.1 ENSMUSG00000141046 ENSMUST00000362713.1 ENSMUSG00000141046 (from geneSymbol) uc337zcr.1 uc337zcr.1 
ENSMUST00000362714.1 ENSMUSG00000141047 ENSMUST00000362714.1 ENSMUSG00000141047 (from geneSymbol) uc337zcs.1 uc337zcs.1 
ENSMUST00000362716.1 ENSMUSG00000141048 ENSMUST00000362716.1 ENSMUSG00000141048 (from geneSymbol) uc337zcu.1 uc337zcu.1 
ENSMUST00000362717.1 Gm31392 ENSMUST00000362717.1 Gm31392 (from geneSymbol) AK132925 uc337zcv.1 uc337zcv.1 
ENSMUST00000362727.1 Gm34648 ENSMUST00000362727.1 Gm34648 (from geneSymbol) uc337zdf.1 uc337zdf.1 
ENSMUST00000362728.1 ENSMUSG00000141049 ENSMUST00000362728.1 ENSMUSG00000141049 (from geneSymbol) uc337zdg.1 uc337zdg.1 
ENSMUST00000362730.1 Gm41277 ENSMUST00000362730.1 Gm41277 (from geneSymbol) uc337zdi.1 uc337zdi.1 
ENSMUST00000362733.1 ENSMUSG00000141050 ENSMUST00000362733.1 ENSMUSG00000141050 (from geneSymbol) uc337zdl.1 uc337zdl.1 
ENSMUST00000362736.1 ENSMUSG00000141051 ENSMUST00000362736.1 ENSMUSG00000141051 (from geneSymbol) uc337zdo.1 uc337zdo.1 
ENSMUST00000362737.1 ENSMUSG00000141052 ENSMUST00000362737.1 ENSMUSG00000141052 (from geneSymbol) uc337zdp.1 uc337zdp.1 
ENSMUST00000362739.1 ENSMUSG00000141053 ENSMUST00000362739.1 ENSMUSG00000141053 (from geneSymbol) uc337zdr.1 uc337zdr.1 
ENSMUST00000362743.1 ENSMUSG00000141054 ENSMUST00000362743.1 ENSMUSG00000141054 (from geneSymbol) uc337zdv.1 uc337zdv.1 
ENSMUST00000362746.1 ENSMUSG00000141055 ENSMUST00000362746.1 ENSMUSG00000141055 (from geneSymbol) uc337zdy.1 uc337zdy.1 
ENSMUST00000362747.1 ENSMUSG00000141056 ENSMUST00000362747.1 ENSMUSG00000141056 (from geneSymbol) uc337zdz.1 uc337zdz.1 
ENSMUST00000362749.1 ENSMUSG00000141057 ENSMUST00000362749.1 ENSMUSG00000141057 (from geneSymbol) uc337zeb.1 uc337zeb.1 
ENSMUST00000362751.1 ENSMUSG00000141058 ENSMUST00000362751.1 ENSMUSG00000141058 (from geneSymbol) uc337zed.1 uc337zed.1 
ENSMUST00000362752.1 ENSMUSG00000141059 ENSMUST00000362752.1 ENSMUSG00000141059 (from geneSymbol) uc337zee.1 uc337zee.1 
ENSMUST00000362753.1 ENSMUSG00000141060 ENSMUST00000362753.1 ENSMUSG00000141060 (from geneSymbol) uc337zef.1 uc337zef.1 
ENSMUST00000362864.1 ENSMUSG00000141061 ENSMUST00000362864.1 ENSMUSG00000141061 (from geneSymbol) uc337zik.1 uc337zik.1 
ENSMUST00000362866.1 ENSMUSG00000141062 ENSMUST00000362866.1 ENSMUSG00000141062 (from geneSymbol) uc337zim.1 uc337zim.1 
ENSMUST00000362868.1 ENSMUSG00000141064 ENSMUST00000362868.1 ENSMUSG00000141064 (from geneSymbol) uc337zin.1 uc337zin.1 
ENSMUST00000362869.1 ENSMUSG00000141065 ENSMUST00000362869.1 ENSMUSG00000141065 (from geneSymbol) uc337zio.1 uc337zio.1 
ENSMUST00000362870.1 ENSMUSG00000141066 ENSMUST00000362870.1 ENSMUSG00000141066 (from geneSymbol) uc337zip.1 uc337zip.1 
ENSMUST00000362871.1 ENSMUSG00000141067 ENSMUST00000362871.1 ENSMUSG00000141067 (from geneSymbol) uc337ziq.1 uc337ziq.1 
ENSMUST00000362872.1 ENSMUSG00000141068 ENSMUST00000362872.1 ENSMUSG00000141068 (from geneSymbol) uc337zir.1 uc337zir.1 
ENSMUST00000362873.1 ENSMUSG00000141069 ENSMUST00000362873.1 ENSMUSG00000141069 (from geneSymbol) uc337zis.1 uc337zis.1 
ENSMUST00000362884.1 ENSMUSG00000141070 ENSMUST00000362884.1 ENSMUSG00000141070 (from geneSymbol) uc337zjc.1 uc337zjc.1 
ENSMUST00000362886.1 ENSMUSG00000141071 ENSMUST00000362886.1 ENSMUSG00000141071 (from geneSymbol) uc337zje.1 uc337zje.1 
ENSMUST00000362887.1 ENSMUSG00000141072 ENSMUST00000362887.1 ENSMUSG00000141072 (from geneSymbol) uc337zjf.1 uc337zjf.1 
ENSMUST00000362888.1 ENSMUSG00000141073 ENSMUST00000362888.1 ENSMUSG00000141073 (from geneSymbol) uc337zjg.1 uc337zjg.1 
ENSMUST00000362889.1 ENSMUSG00000141074 ENSMUST00000362889.1 ENSMUSG00000141074 (from geneSymbol) uc337zjh.1 uc337zjh.1 
ENSMUST00000362890.1 ENSMUSG00000141075 ENSMUST00000362890.1 ENSMUSG00000141075 (from geneSymbol) uc337zji.1 uc337zji.1 
ENSMUST00000362891.1 ENSMUSG00000141076 ENSMUST00000362891.1 ENSMUSG00000141076 (from geneSymbol) uc337zjj.1 uc337zjj.1 
ENSMUST00000362892.1 4930522O17Rik ENSMUST00000362892.1 4930522O17Rik (from geneSymbol) AK019691 uc337zjk.1 uc337zjk.1 
ENSMUST00000362911.1 ENSMUSG00000141077 ENSMUST00000362911.1 ENSMUSG00000141077 (from geneSymbol) uc337zkd.1 uc337zkd.1 
ENSMUST00000362931.1 ENSMUSG00000141078 ENSMUST00000362931.1 ENSMUSG00000141078 (from geneSymbol) uc337zkx.1 uc337zkx.1 
ENSMUST00000362942.1 ENSMUSG00000141079 ENSMUST00000362942.1 ENSMUSG00000141079 (from geneSymbol) uc337zli.1 uc337zli.1 
ENSMUST00000362950.1 ENSMUSG00000141080 ENSMUST00000362950.1 ENSMUSG00000141080 (from geneSymbol) uc337zlq.1 uc337zlq.1 
ENSMUST00000362953.1 Gm11967 ENSMUST00000362953.1 Gm11967 (from geneSymbol) uc337zlt.1 uc337zlt.1 
ENSMUST00000362959.1 ENSMUSG00000141081 ENSMUST00000362959.1 ENSMUSG00000141081 (from geneSymbol) uc337zlz.1 uc337zlz.1 
ENSMUST00000362960.1 ENSMUSG00000141082 ENSMUST00000362960.1 ENSMUSG00000141082 (from geneSymbol) uc337zma.1 uc337zma.1 
ENSMUST00000362961.1 Gm56554 ENSMUST00000362961.1 Gm56554 (from geneSymbol) AK021345 uc337zmb.1 uc337zmb.1 
ENSMUST00000362963.1 ENSMUSG00000141083 ENSMUST00000362963.1 ENSMUSG00000141083 (from geneSymbol) uc337zmd.1 uc337zmd.1 
ENSMUST00000362965.1 ENSMUSG00000141084 ENSMUST00000362965.1 ENSMUSG00000141084 (from geneSymbol) uc337zmf.1 uc337zmf.1 
ENSMUST00000362971.1 ENSMUSG00000141085 ENSMUST00000362971.1 ENSMUSG00000141085 (from geneSymbol) uc337zml.1 uc337zml.1 
ENSMUST00000362976.1 Zbed5-ps ENSMUST00000362976.1 Zbed5-ps (from geneSymbol) AK005898 uc337zmq.1 uc337zmq.1 
ENSMUST00000362986.1 ENSMUSG00000141086 ENSMUST00000362986.1 ENSMUSG00000141086 (from geneSymbol) uc337zna.1 uc337zna.1 
ENSMUST00000362988.1 ENSMUSG00000141087 ENSMUST00000362988.1 ENSMUSG00000141087 (from geneSymbol) uc337znc.1 uc337znc.1 
ENSMUST00000362992.1 ENSMUSG00000141088 ENSMUST00000362992.1 ENSMUSG00000141088 (from geneSymbol) uc337zng.1 uc337zng.1 
ENSMUST00000363004.1 ENSMUSG00000141090 ENSMUST00000363004.1 ENSMUSG00000141090 (from geneSymbol) uc337znr.1 uc337znr.1 
ENSMUST00000363005.1 ENSMUSG00000141091 ENSMUST00000363005.1 ENSMUSG00000141091 (from geneSymbol) uc337zns.1 uc337zns.1 
ENSMUST00000363021.1 ENSMUSG00000141092 ENSMUST00000363021.1 ENSMUSG00000141092 (from geneSymbol) uc337zoi.1 uc337zoi.1 
ENSMUST00000363023.1 ENSMUSG00000141093 ENSMUST00000363023.1 ENSMUSG00000141093 (from geneSymbol) uc337zok.1 uc337zok.1 
ENSMUST00000363026.1 Gm38132 ENSMUST00000363026.1 Gm38132 (from geneSymbol) uc337zon.1 uc337zon.1 
ENSMUST00000363037.1 Junos ENSMUST00000363037.1 Junos (from geneSymbol) BC042782 uc337zoy.1 uc337zoy.1 
ENSMUST00000363087.1 ENSMUSG00000141094 ENSMUST00000363087.1 ENSMUSG00000141094 (from geneSymbol) uc337zqw.1 uc337zqw.1 
ENSMUST00000363098.1 ENSMUSG00000141095 ENSMUST00000363098.1 ENSMUSG00000141095 (from geneSymbol) uc337zrh.1 uc337zrh.1 
ENSMUST00000363101.1 ENSMUSG00000141096 ENSMUST00000363101.1 ENSMUSG00000141096 (from geneSymbol) uc337zrk.1 uc337zrk.1 
ENSMUST00000363103.1 ENSMUSG00000141097 ENSMUST00000363103.1 ENSMUSG00000141097 (from geneSymbol) uc337zrm.1 uc337zrm.1 
ENSMUST00000363104.1 ENSMUSG00000141098 ENSMUST00000363104.1 ENSMUSG00000141098 (from geneSymbol) uc337zrn.1 uc337zrn.1 
ENSMUST00000363107.1 ENSMUSG00000141099 ENSMUST00000363107.1 ENSMUSG00000141099 (from geneSymbol) uc337zrq.1 uc337zrq.1 
ENSMUST00000363111.1 ENSMUSG00000141100 ENSMUST00000363111.1 ENSMUSG00000141100 (from geneSymbol) uc337zru.1 uc337zru.1 
ENSMUST00000363112.1 ENSMUSG00000141101 ENSMUST00000363112.1 ENSMUSG00000141101 (from geneSymbol) uc337zrv.1 uc337zrv.1 
ENSMUST00000363114.1 ENSMUSG00000141102 ENSMUST00000363114.1 ENSMUSG00000141102 (from geneSymbol) uc337zrx.1 uc337zrx.1 
ENSMUST00000363116.1 ENSMUSG00000141103 ENSMUST00000363116.1 ENSMUSG00000141103 (from geneSymbol) uc337zrz.1 uc337zrz.1 
ENSMUST00000363117.1 ENSMUSG00000141104 ENSMUST00000363117.1 ENSMUSG00000141104 (from geneSymbol) uc337zsa.1 uc337zsa.1 
ENSMUST00000363124.1 ENSMUSG00000141105 ENSMUST00000363124.1 ENSMUSG00000141105 (from geneSymbol) uc337zsh.1 uc337zsh.1 
ENSMUST00000363128.1 ENSMUSG00000141106 ENSMUST00000363128.1 ENSMUSG00000141106 (from geneSymbol) uc337zsl.1 uc337zsl.1 
ENSMUST00000363134.1 ENSMUSG00000141107 ENSMUST00000363134.1 ENSMUSG00000141107 (from geneSymbol) uc337zsr.1 uc337zsr.1 
ENSMUST00000363135.1 ENSMUSG00000141108 ENSMUST00000363135.1 ENSMUSG00000141108 (from geneSymbol) uc337zss.1 uc337zss.1 
ENSMUST00000363139.1 ENSMUSG00000141109 ENSMUST00000363139.1 ENSMUSG00000141109 (from geneSymbol) uc337zsw.1 uc337zsw.1 
ENSMUST00000363140.1 4930500F10Rik ENSMUST00000363140.1 4930500F10Rik (from geneSymbol) AK015659 uc337zsx.1 uc337zsx.1 
ENSMUST00000363205.1 ENSMUSG00000141110 ENSMUST00000363205.1 ENSMUSG00000141110 (from geneSymbol) uc337zvk.1 uc337zvk.1 
ENSMUST00000363206.1 ENSMUSG00000141111 ENSMUST00000363206.1 ENSMUSG00000141111 (from geneSymbol) uc337zvl.1 uc337zvl.1 
ENSMUST00000363209.1 ENSMUSG00000141112 ENSMUST00000363209.1 ENSMUSG00000141112 (from geneSymbol) uc337zvo.1 uc337zvo.1 
ENSMUST00000363215.1 Gm57146 ENSMUST00000363215.1 Gm57146 (from geneSymbol) uc337zvu.1 uc337zvu.1 
ENSMUST00000363245.1 ENSMUSG00000141113 ENSMUST00000363245.1 ENSMUSG00000141113 (from geneSymbol) uc337zwy.1 uc337zwy.1 
ENSMUST00000363246.1 4930429F24Rik ENSMUST00000363246.1 4930429F24Rik (from geneSymbol) AK015237 uc337zwz.1 uc337zwz.1 
ENSMUST00000363254.1 ENSMUSG00000141114 ENSMUST00000363254.1 ENSMUSG00000141114 (from geneSymbol) uc337zxh.1 uc337zxh.1 
ENSMUST00000363255.1 ENSMUSG00000141115 ENSMUST00000363255.1 ENSMUSG00000141115 (from geneSymbol) uc337zxi.1 uc337zxi.1 
ENSMUST00000363257.1 ENSMUSG00000141116 ENSMUST00000363257.1 ENSMUSG00000141116 (from geneSymbol) uc337zxk.1 uc337zxk.1 
ENSMUST00000363260.1 ENSMUSG00000141117 ENSMUST00000363260.1 ENSMUSG00000141117 (from geneSymbol) uc337zxn.1 uc337zxn.1 
ENSMUST00000363261.1 Gm29387 ENSMUST00000363261.1 Gm29387 (from geneSymbol) uc337zxo.1 uc337zxo.1 
ENSMUST00000363266.1 ENSMUSG00000141118 ENSMUST00000363266.1 ENSMUSG00000141118 (from geneSymbol) uc337zxt.1 uc337zxt.1 
ENSMUST00000363267.1 ENSMUSG00000141119 ENSMUST00000363267.1 ENSMUSG00000141119 (from geneSymbol) uc337zxu.1 uc337zxu.1 
ENSMUST00000363273.1 Gm36180 ENSMUST00000363273.1 Gm36180 (from geneSymbol) uc337zya.1 uc337zya.1 
ENSMUST00000363275.1 ENSMUSG00000141120 ENSMUST00000363275.1 ENSMUSG00000141120 (from geneSymbol) uc337zyc.1 uc337zyc.1 
ENSMUST00000363278.1 ENSMUSG00000141121 ENSMUST00000363278.1 ENSMUSG00000141121 (from geneSymbol) uc337zyf.1 uc337zyf.1 
ENSMUST00000363281.1 ENSMUSG00000141122 ENSMUST00000363281.1 ENSMUSG00000141122 (from geneSymbol) uc337zyi.1 uc337zyi.1 
ENSMUST00000363282.1 ENSMUSG00000141123 ENSMUST00000363282.1 ENSMUSG00000141123 (from geneSymbol) uc337zyj.1 uc337zyj.1 
ENSMUST00000363284.1 ENSMUSG00000141124 ENSMUST00000363284.1 ENSMUSG00000141124 (from geneSymbol) uc337zyl.1 uc337zyl.1 
ENSMUST00000363285.1 ENSMUSG00000141125 ENSMUST00000363285.1 ENSMUSG00000141125 (from geneSymbol) uc337zym.1 uc337zym.1 
ENSMUST00000363287.1 Gm13074 ENSMUST00000363287.1 Gm13074 (from geneSymbol) AK036785 uc337zyo.1 uc337zyo.1 
ENSMUST00000363289.1 ENSMUSG00000141126 ENSMUST00000363289.1 ENSMUSG00000141126 (from geneSymbol) uc337zyq.1 uc337zyq.1 
ENSMUST00000363290.1 ENSMUSG00000141127 ENSMUST00000363290.1 ENSMUSG00000141127 (from geneSymbol) uc337zyr.1 uc337zyr.1 
ENSMUST00000363294.1 ENSMUSG00000141128 ENSMUST00000363294.1 ENSMUSG00000141128 (from geneSymbol) uc337zyv.1 uc337zyv.1 
ENSMUST00000363296.1 ENSMUSG00000141129 ENSMUST00000363296.1 ENSMUSG00000141129 (from geneSymbol) uc337zyx.1 uc337zyx.1 
ENSMUST00000363298.1 ENSMUSG00000141130 ENSMUST00000363298.1 ENSMUSG00000141130 (from geneSymbol) uc337zyz.1 uc337zyz.1 
ENSMUST00000363299.1 ENSMUSG00000141131 ENSMUST00000363299.1 ENSMUSG00000141131 (from geneSymbol) uc337zza.1 uc337zza.1 
ENSMUST00000363301.1 ENSMUSG00000141132 ENSMUST00000363301.1 ENSMUSG00000141132 (from geneSymbol) uc337zzc.1 uc337zzc.1 
ENSMUST00000363302.1 ENSMUSG00000141133 ENSMUST00000363302.1 ENSMUSG00000141133 (from geneSymbol) uc337zzd.1 uc337zzd.1 
ENSMUST00000363304.1 ENSMUSG00000141134 ENSMUST00000363304.1 ENSMUSG00000141134 (from geneSymbol) uc337zzf.1 uc337zzf.1 
ENSMUST00000363305.1 ENSMUSG00000141135 ENSMUST00000363305.1 ENSMUSG00000141135 (from geneSymbol) uc337zzg.1 uc337zzg.1 
ENSMUST00000363306.1 ENSMUSG00000141136 ENSMUST00000363306.1 ENSMUSG00000141136 (from geneSymbol) uc337zzh.1 uc337zzh.1 
ENSMUST00000363307.1 ENSMUSG00000141137 ENSMUST00000363307.1 ENSMUSG00000141137 (from geneSymbol) uc337zzi.1 uc337zzi.1 
ENSMUST00000363308.1 Gm32005 ENSMUST00000363308.1 Gm32005 (from geneSymbol) uc337zzj.1 uc337zzj.1 
ENSMUST00000363315.1 ENSMUSG00000141138 ENSMUST00000363315.1 ENSMUSG00000141138 (from geneSymbol) uc337zzq.1 uc337zzq.1 
ENSMUST00000363316.1 ENSMUSG00000141139 ENSMUST00000363316.1 ENSMUSG00000141139 (from geneSymbol) uc337zzr.1 uc337zzr.1 
ENSMUST00000363318.1 ENSMUSG00000141140 ENSMUST00000363318.1 ENSMUSG00000141140 (from geneSymbol) uc337zzt.1 uc337zzt.1 
ENSMUST00000363322.1 ENSMUSG00000141141 ENSMUST00000363322.1 ENSMUSG00000141141 (from geneSymbol) uc337zzx.1 uc337zzx.1 
ENSMUST00000363323.1 ENSMUSG00000141142 ENSMUST00000363323.1 ENSMUSG00000141142 (from geneSymbol) uc337zzy.1 uc337zzy.1 
ENSMUST00000363326.1 9030616G12Rik ENSMUST00000363326.1 9030616G12Rik (from geneSymbol) AK020256 uc338aab.1 uc338aab.1 
ENSMUST00000363328.1 ENSMUSG00000141143 ENSMUST00000363328.1 ENSMUSG00000141143 (from geneSymbol) AK018848 uc338aad.1 uc338aad.1 
ENSMUST00000363329.1 Gm34698 ENSMUST00000363329.1 Gm34698 (from geneSymbol) uc338aae.1 uc338aae.1 
ENSMUST00000363347.1 ENSMUSG00000141145 ENSMUST00000363347.1 ENSMUSG00000141145 (from geneSymbol) uc338aaw.1 uc338aaw.1 
ENSMUST00000363353.1 ENSMUSG00000141146 ENSMUST00000363353.1 ENSMUSG00000141146 (from geneSymbol) uc338abc.1 uc338abc.1 
ENSMUST00000363354.1 ENSMUSG00000141147 ENSMUST00000363354.1 ENSMUSG00000141147 (from geneSymbol) uc338abd.1 uc338abd.1 
ENSMUST00000363355.1 ENSMUSG00000141148 ENSMUST00000363355.1 ENSMUSG00000141148 (from geneSymbol) uc338abe.1 uc338abe.1 
ENSMUST00000363356.1 Gm57023 ENSMUST00000363356.1 Gm57023 (from geneSymbol) uc338abf.1 uc338abf.1 
ENSMUST00000363358.1 ENSMUSG00000141149 ENSMUST00000363358.1 ENSMUSG00000141149 (from geneSymbol) uc338abh.1 uc338abh.1 
ENSMUST00000363360.1 4930518C09Rik ENSMUST00000363360.1 4930518C09Rik (from geneSymbol) AK015822 uc338abj.1 uc338abj.1 
ENSMUST00000363364.1 ENSMUSG00000141150 ENSMUST00000363364.1 ENSMUSG00000141150 (from geneSymbol) uc338abn.1 uc338abn.1 
ENSMUST00000363367.1 ENSMUSG00000141151 ENSMUST00000363367.1 ENSMUSG00000141151 (from geneSymbol) uc338abq.1 uc338abq.1 
ENSMUST00000363375.1 ENSMUSG00000141152 ENSMUST00000363375.1 ENSMUSG00000141152 (from geneSymbol) uc338aby.1 uc338aby.1 
ENSMUST00000363378.1 ENSMUSG00000141153 ENSMUST00000363378.1 ENSMUSG00000141153 (from geneSymbol) uc338acb.1 uc338acb.1 
ENSMUST00000363379.1 ENSMUSG00000141154 ENSMUST00000363379.1 ENSMUSG00000141154 (from geneSymbol) uc338acc.1 uc338acc.1 
ENSMUST00000363381.1 ENSMUSG00000141155 ENSMUST00000363381.1 ENSMUSG00000141155 (from geneSymbol) uc338ace.1 uc338ace.1 
ENSMUST00000363383.1 ENSMUSG00000141156 ENSMUST00000363383.1 ENSMUSG00000141156 (from geneSymbol) uc338acg.1 uc338acg.1 
ENSMUST00000363394.1 ENSMUSG00000141157 ENSMUST00000363394.1 ENSMUSG00000141157 (from geneSymbol) uc338acr.1 uc338acr.1 
ENSMUST00000363397.1 Gm28822 ENSMUST00000363397.1 Gm28822 (from geneSymbol) uc338acu.1 uc338acu.1 
ENSMUST00000363403.1 Ccdc142os ENSMUST00000363403.1 Ccdc142os (from geneSymbol) AK161590 uc338ada.1 uc338ada.1 
ENSMUST00000363415.1 Gm34597 ENSMUST00000363415.1 Gm34597 (from geneSymbol) uc338adm.1 uc338adm.1 
ENSMUST00000363445.1 C230038L03Rik ENSMUST00000363445.1 C230038L03Rik (from geneSymbol) AK132765 uc338aeq.1 uc338aeq.1 
ENSMUST00000363473.1 ENSMUSG00000141158 ENSMUST00000363473.1 ENSMUSG00000141158 (from geneSymbol) uc338afs.1 uc338afs.1 
ENSMUST00000363475.1 ENSMUSG00000141159 ENSMUST00000363475.1 ENSMUSG00000141159 (from geneSymbol) uc338afu.1 uc338afu.1 
ENSMUST00000363477.1 ENSMUSG00000141160 ENSMUST00000363477.1 ENSMUSG00000141160 (from geneSymbol) uc338afw.1 uc338afw.1 
ENSMUST00000363482.1 ENSMUSG00000141161 ENSMUST00000363482.1 ENSMUSG00000141161 (from geneSymbol) uc338agb.1 uc338agb.1 
ENSMUST00000363484.1 ENSMUSG00000141162 ENSMUST00000363484.1 ENSMUSG00000141162 (from geneSymbol) uc338agd.1 uc338agd.1 
ENSMUST00000363486.1 ENSMUSG00000141163 ENSMUST00000363486.1 ENSMUSG00000141163 (from geneSymbol) uc338agf.1 uc338agf.1 
ENSMUST00000363487.1 Gm49490 ENSMUST00000363487.1 Gm49490 (from geneSymbol) uc338agg.1 uc338agg.1 
ENSMUST00000363493.1 ENSMUSG00000141164 ENSMUST00000363493.1 ENSMUSG00000141164 (from geneSymbol) uc338agm.1 uc338agm.1 
ENSMUST00000363496.1 Gm41485 ENSMUST00000363496.1 Gm41485 (from geneSymbol) uc338agp.1 uc338agp.1 
ENSMUST00000363503.1 ENSMUSG00000141165 ENSMUST00000363503.1 ENSMUSG00000141165 (from geneSymbol) uc338agw.1 uc338agw.1 
ENSMUST00000363513.1 ENSMUSG00000141166 ENSMUST00000363513.1 ENSMUSG00000141166 (from geneSymbol) uc338ahg.1 uc338ahg.1 
ENSMUST00000363519.1 Gm39027 ENSMUST00000363519.1 Gm39027 (from geneSymbol) uc338ahm.1 uc338ahm.1 
ENSMUST00000363527.1 ENSMUSG00000141167 ENSMUST00000363527.1 ENSMUSG00000141167 (from geneSymbol) uc338ahu.1 uc338ahu.1 
ENSMUST00000363529.1 ENSMUSG00000141168 ENSMUST00000363529.1 ENSMUSG00000141168 (from geneSymbol) uc338ahw.1 uc338ahw.1 
ENSMUST00000363530.1 ENSMUSG00000141169 ENSMUST00000363530.1 ENSMUSG00000141169 (from geneSymbol) uc338ahx.1 uc338ahx.1 
ENSMUST00000363531.1 4930551L18Rik ENSMUST00000363531.1 4930551L18Rik (from geneSymbol) AK016095 uc338ahy.1 uc338ahy.1 
ENSMUST00000363534.1 9330179D12Rik ENSMUST00000363534.1 9330179D12Rik (from geneSymbol) AK020388 uc338aib.1 uc338aib.1 
ENSMUST00000363554.1 ENSMUSG00000141170 ENSMUST00000363554.1 ENSMUSG00000141170 (from geneSymbol) uc338aiv.1 uc338aiv.1 
ENSMUST00000363556.1 ENSMUSG00000141171 ENSMUST00000363556.1 ENSMUSG00000141171 (from geneSymbol) uc338aix.1 uc338aix.1 
ENSMUST00000363557.1 ENSMUSG00000141172 ENSMUST00000363557.1 ENSMUSG00000141172 (from geneSymbol) uc338aiy.1 uc338aiy.1 
ENSMUST00000363558.1 ENSMUSG00000141173 ENSMUST00000363558.1 ENSMUSG00000141173 (from geneSymbol) uc338aiz.1 uc338aiz.1 
ENSMUST00000363572.1 ENSMUSG00000141174 ENSMUST00000363572.1 ENSMUSG00000141174 (from geneSymbol) uc338ajn.1 uc338ajn.1 
ENSMUST00000363573.1 ENSMUSG00000141175 ENSMUST00000363573.1 ENSMUSG00000141175 (from geneSymbol) LF197644 uc338ajo.1 uc338ajo.1 
ENSMUST00000363574.1 ENSMUSG00000141176 ENSMUST00000363574.1 ENSMUSG00000141176 (from geneSymbol) uc338ajp.1 uc338ajp.1 
ENSMUST00000363575.1 ENSMUSG00000141177 ENSMUST00000363575.1 ENSMUSG00000141177 (from geneSymbol) uc338ajq.1 uc338ajq.1 
ENSMUST00000363577.1 Gm43132 ENSMUST00000363577.1 Gm43132 (from geneSymbol) AK007142 uc338ajs.1 uc338ajs.1 
ENSMUST00000363585.1 ENSMUSG00000141178 ENSMUST00000363585.1 ENSMUSG00000141178 (from geneSymbol) uc338aka.1 uc338aka.1 
ENSMUST00000363587.1 ENSMUSG00000141179 ENSMUST00000363587.1 ENSMUSG00000141179 (from geneSymbol) uc338akc.1 uc338akc.1 
ENSMUST00000363588.1 Gm43538 ENSMUST00000363588.1 Gm43538 (from geneSymbol) uc338akd.1 uc338akd.1 
ENSMUST00000363589.1 ENSMUSG00000141180 ENSMUST00000363589.1 ENSMUSG00000141180 (from geneSymbol) uc338ake.1 uc338ake.1 
ENSMUST00000363590.1 ENSMUSG00000141181 ENSMUST00000363590.1 ENSMUSG00000141181 (from geneSymbol) uc338akf.1 uc338akf.1 
ENSMUST00000363592.1 ENSMUSG00000141182 ENSMUST00000363592.1 ENSMUSG00000141182 (from geneSymbol) uc338akh.1 uc338akh.1 
ENSMUST00000363621.1 ENSMUSG00000141183 ENSMUST00000363621.1 ENSMUSG00000141183 (from geneSymbol) uc338alk.1 uc338alk.1 
ENSMUST00000363625.1 4930512J16Rik ENSMUST00000363625.1 4930512J16Rik (from geneSymbol) AK155560 uc338aln.1 uc338aln.1 
ENSMUST00000363642.1 ENSMUSG00000141185 ENSMUST00000363642.1 ENSMUSG00000141185 (from geneSymbol) uc338ame.1 uc338ame.1 
ENSMUST00000363643.1 ENSMUSG00000141186 ENSMUST00000363643.1 ENSMUSG00000141186 (from geneSymbol) uc338amf.1 uc338amf.1 
ENSMUST00000363645.1 Gm48740 ENSMUST00000363645.1 Gm48740 (from geneSymbol) uc338amh.1 uc338amh.1 
ENSMUST00000363651.1 Gm34609 ENSMUST00000363651.1 Gm34609 (from geneSymbol) uc338amm.1 uc338amm.1 
ENSMUST00000363655.1 ENSMUSG00000141187 ENSMUST00000363655.1 ENSMUSG00000141187 (from geneSymbol) uc338amq.1 uc338amq.1 
ENSMUST00000363658.1 ENSMUSG00000141188 ENSMUST00000363658.1 ENSMUSG00000141188 (from geneSymbol) uc338amt.1 uc338amt.1 
ENSMUST00000363659.1 ENSMUSG00000141189 ENSMUST00000363659.1 ENSMUSG00000141189 (from geneSymbol) uc338amu.1 uc338amu.1 
ENSMUST00000363660.1 ENSMUSG00000141190 ENSMUST00000363660.1 ENSMUSG00000141190 (from geneSymbol) uc338amv.1 uc338amv.1 
ENSMUST00000363667.1 Gm34474 ENSMUST00000363667.1 Gm34474 (from geneSymbol) uc338anc.1 uc338anc.1 
ENSMUST00000363673.1 ENSMUSG00000141191 ENSMUST00000363673.1 ENSMUSG00000141191 (from geneSymbol) uc338ani.1 uc338ani.1 
ENSMUST00000363674.1 Gm49334 ENSMUST00000363674.1 Gm49334 (from geneSymbol) uc338anj.1 uc338anj.1 
ENSMUST00000363699.1 ENSMUSG00000141192 ENSMUST00000363699.1 ENSMUSG00000141192 (from geneSymbol) uc338aoi.1 uc338aoi.1 
ENSMUST00000363700.1 ENSMUSG00000141193 ENSMUST00000363700.1 ENSMUSG00000141193 (from geneSymbol) uc338aoj.1 uc338aoj.1 
ENSMUST00000363701.1 ENSMUSG00000141194 ENSMUST00000363701.1 ENSMUSG00000141194 (from geneSymbol) uc338aok.1 uc338aok.1 
ENSMUST00000363707.1 ENSMUSG00000141195 ENSMUST00000363707.1 ENSMUSG00000141195 (from geneSymbol) uc338aoq.1 uc338aoq.1 
ENSMUST00000363709.1 ENSMUSG00000141196 ENSMUST00000363709.1 ENSMUSG00000141196 (from geneSymbol) uc338aos.1 uc338aos.1 
ENSMUST00000363717.1 ENSMUSG00000141197 ENSMUST00000363717.1 ENSMUSG00000141197 (from geneSymbol) uc338apa.1 uc338apa.1 
ENSMUST00000363724.1 ENSMUSG00000141198 ENSMUST00000363724.1 ENSMUSG00000141198 (from geneSymbol) uc338aph.1 uc338aph.1 
ENSMUST00000363739.1 ENSMUSG00000141199 ENSMUST00000363739.1 ENSMUSG00000141199 (from geneSymbol) uc338apw.1 uc338apw.1 
ENSMUST00000363741.1 ENSMUSG00000141200 ENSMUST00000363741.1 ENSMUSG00000141200 (from geneSymbol) uc338apy.1 uc338apy.1 
ENSMUST00000363754.1 ENSMUSG00000141201 ENSMUST00000363754.1 ENSMUSG00000141201 (from geneSymbol) uc338aql.1 uc338aql.1 
ENSMUST00000363755.1 ENSMUSG00000141202 ENSMUST00000363755.1 ENSMUSG00000141202 (from geneSymbol) uc338aqm.1 uc338aqm.1 
ENSMUST00000363757.1 ENSMUSG00000141203 ENSMUST00000363757.1 ENSMUSG00000141203 (from geneSymbol) uc338aqo.1 uc338aqo.1 
ENSMUST00000363758.1 ENSMUSG00000141204 ENSMUST00000363758.1 ENSMUSG00000141204 (from geneSymbol) uc338aqp.1 uc338aqp.1 
ENSMUST00000363759.1 ENSMUSG00000141205 ENSMUST00000363759.1 ENSMUSG00000141205 (from geneSymbol) uc338aqq.1 uc338aqq.1 
ENSMUST00000363760.1 ENSMUSG00000141206 ENSMUST00000363760.1 ENSMUSG00000141206 (from geneSymbol) uc338aqr.1 uc338aqr.1 
ENSMUST00000363761.1 ENSMUSG00000141207 ENSMUST00000363761.1 ENSMUSG00000141207 (from geneSymbol) uc338aqs.1 uc338aqs.1 
ENSMUST00000363764.1 Zfas1 ENSMUST00000363764.1 Zfas1 (from geneSymbol) BC042795 uc338aqv.1 uc338aqv.1 
ENSMUST00000363780.1 ENSMUSG00000141208 ENSMUST00000363780.1 ENSMUSG00000141208 (from geneSymbol) uc338arl.1 uc338arl.1 
ENSMUST00000363784.1 ENSMUSG00000141209 ENSMUST00000363784.1 ENSMUSG00000141209 (from geneSymbol) uc338arp.1 uc338arp.1 
ENSMUST00000363825.1 1700061F12Rik ENSMUST00000363825.1 1700061F12Rik (from geneSymbol) AK006852 uc338atd.1 uc338atd.1 
ENSMUST00000363834.1 ENSMUSG00000141210 ENSMUST00000363834.1 ENSMUSG00000141210 (from geneSymbol) uc338atm.1 uc338atm.1 
ENSMUST00000363836.1 ENSMUSG00000141211 ENSMUST00000363836.1 ENSMUSG00000141211 (from geneSymbol) uc338ato.1 uc338ato.1 
ENSMUST00000363839.1 ENSMUSG00000141212 ENSMUST00000363839.1 ENSMUSG00000141212 (from geneSymbol) uc338atr.1 uc338atr.1 
ENSMUST00000363841.1 ENSMUSG00000141213 ENSMUST00000363841.1 ENSMUSG00000141213 (from geneSymbol) uc338att.1 uc338att.1 
ENSMUST00000363844.1 ENSMUSG00000141214 ENSMUST00000363844.1 ENSMUSG00000141214 (from geneSymbol) uc338atw.1 uc338atw.1 
ENSMUST00000363848.1 Slfn5os ENSMUST00000363848.1 Slfn5os (from geneSymbol) AK005634 uc338aua.1 uc338aua.1 
ENSMUST00000363860.1 ENSMUSG00000141215 ENSMUST00000363860.1 ENSMUSG00000141215 (from geneSymbol) uc338aum.1 uc338aum.1 
ENSMUST00000363866.1 ENSMUSG00000141216 ENSMUST00000363866.1 ENSMUSG00000141216 (from geneSymbol) uc338aus.1 uc338aus.1 
ENSMUST00000363867.1 ENSMUSG00000141217 ENSMUST00000363867.1 ENSMUSG00000141217 (from geneSymbol) uc338aut.1 uc338aut.1 
ENSMUST00000363869.1 ENSMUSG00000141218 ENSMUST00000363869.1 ENSMUSG00000141218 (from geneSymbol) uc338auv.1 uc338auv.1 
ENSMUST00000363871.1 ENSMUSG00000141219 ENSMUST00000363871.1 ENSMUSG00000141219 (from geneSymbol) uc338aux.1 uc338aux.1 
ENSMUST00000363872.1 ENSMUSG00000141220 ENSMUST00000363872.1 ENSMUSG00000141220 (from geneSymbol) uc338auy.1 uc338auy.1 
ENSMUST00000363873.1 Gm48010 ENSMUST00000363873.1 Gm48010 (from geneSymbol) uc338auz.1 uc338auz.1 
ENSMUST00000363875.1 ENSMUSG00000141221 ENSMUST00000363875.1 ENSMUSG00000141221 (from geneSymbol) uc338avb.1 uc338avb.1 
ENSMUST00000363879.1 ENSMUSG00000141222 ENSMUST00000363879.1 ENSMUSG00000141222 (from geneSymbol) uc338avf.1 uc338avf.1 
ENSMUST00000363880.1 ENSMUSG00000141223 ENSMUST00000363880.1 ENSMUSG00000141223 (from geneSymbol) uc338avg.1 uc338avg.1 
ENSMUST00000363882.1 ENSMUSG00000141224 ENSMUST00000363882.1 ENSMUSG00000141224 (from geneSymbol) uc338avi.1 uc338avi.1 
ENSMUST00000363886.1 ENSMUSG00000141225 ENSMUST00000363886.1 ENSMUSG00000141225 (from geneSymbol) uc338avm.1 uc338avm.1 
ENSMUST00000363888.1 ENSMUSG00000141226 ENSMUST00000363888.1 ENSMUSG00000141226 (from geneSymbol) uc338avo.1 uc338avo.1 
ENSMUST00000363892.1 ENSMUSG00000141227 ENSMUST00000363892.1 ENSMUSG00000141227 (from geneSymbol) uc338avs.1 uc338avs.1 
ENSMUST00000363893.1 ENSMUSG00000141228 ENSMUST00000363893.1 ENSMUSG00000141228 (from geneSymbol) uc338avt.1 uc338avt.1 
ENSMUST00000363894.1 ENSMUSG00000141229 ENSMUST00000363894.1 ENSMUSG00000141229 (from geneSymbol) uc338avu.1 uc338avu.1 
ENSMUST00000363895.1 ENSMUSG00000141230 ENSMUST00000363895.1 ENSMUSG00000141230 (from geneSymbol) uc338avv.1 uc338avv.1 
ENSMUST00000363896.1 Gm34533 ENSMUST00000363896.1 Gm34533 (from geneSymbol) uc338avw.1 uc338avw.1 
ENSMUST00000363898.1 ENSMUSG00000141231 ENSMUST00000363898.1 ENSMUSG00000141231 (from geneSymbol) uc338avy.1 uc338avy.1 
ENSMUST00000363899.1 ENSMUSG00000141232 ENSMUST00000363899.1 ENSMUSG00000141232 (from geneSymbol) uc338avz.1 uc338avz.1 
ENSMUST00000363900.1 9230112J17Rik ENSMUST00000363900.1 RIKEN cDNA 9230112J17 gene, transcript variant 1 (from RefSeq NR_040463.1) NR_040463 uc338awa.1 uc338awa.1 
ENSMUST00000363915.1 ENSMUSG00000141233 ENSMUST00000363915.1 ENSMUSG00000141233 (from geneSymbol) uc338awp.1 uc338awp.1 
ENSMUST00000363919.1 ENSMUSG00000141234 ENSMUST00000363919.1 ENSMUSG00000141234 (from geneSymbol) uc338awt.1 uc338awt.1 
ENSMUST00000363926.1 ENSMUSG00000141235 ENSMUST00000363926.1 ENSMUSG00000141235 (from geneSymbol) uc338axa.1 uc338axa.1 
ENSMUST00000363927.1 ENSMUSG00000141236 ENSMUST00000363927.1 ENSMUSG00000141236 (from geneSymbol) uc338axb.1 uc338axb.1 
ENSMUST00000363928.1 ENSMUSG00000141237 ENSMUST00000363928.1 ENSMUSG00000141237 (from geneSymbol) uc338axc.1 uc338axc.1 
ENSMUST00000363929.1 ENSMUSG00000141238 ENSMUST00000363929.1 ENSMUSG00000141238 (from geneSymbol) uc338axd.1 uc338axd.1 
ENSMUST00000363930.1 ENSMUSG00000141239 ENSMUST00000363930.1 ENSMUSG00000141239 (from geneSymbol) uc338axe.1 uc338axe.1 
ENSMUST00000363932.1 ENSMUSG00000141240 ENSMUST00000363932.1 ENSMUSG00000141240 (from geneSymbol) uc338axg.1 uc338axg.1 
ENSMUST00000363945.1 ENSMUSG00000141241 ENSMUST00000363945.1 ENSMUSG00000141241 (from geneSymbol) uc338axt.1 uc338axt.1 
ENSMUST00000363949.1 ENSMUSG00000141242 ENSMUST00000363949.1 ENSMUSG00000141242 (from geneSymbol) uc338axx.1 uc338axx.1 
ENSMUST00000363950.1 ENSMUSG00000141243 ENSMUST00000363950.1 ENSMUSG00000141243 (from geneSymbol) uc338axy.1 uc338axy.1 
ENSMUST00000363962.1 Platr4 ENSMUST00000363962.1 Platr4 (from geneSymbol) AK021232 uc338ayk.1 uc338ayk.1 
ENSMUST00000364080.1 ENSMUSG00000141244 ENSMUST00000364080.1 ENSMUSG00000141244 (from geneSymbol) uc338bcy.1 uc338bcy.1 
ENSMUST00000364179.1 ENSMUSG00000141245 ENSMUST00000364179.1 ENSMUSG00000141245 (from geneSymbol) uc338bgt.1 uc338bgt.1 
ENSMUST00000364181.1 Platr12 ENSMUST00000364181.1 Platr12 (from geneSymbol) AB777270 uc338bgu.1 uc338bgu.1 
ENSMUST00000364204.1 ENSMUSG00000141247 ENSMUST00000364204.1 ENSMUSG00000141247 (from geneSymbol) uc338bhr.1 uc338bhr.1 
ENSMUST00000364206.1 ENSMUSG00000141248 ENSMUST00000364206.1 ENSMUSG00000141248 (from geneSymbol) uc338bht.1 uc338bht.1 
ENSMUST00000364207.1 ENSMUSG00000141249 ENSMUST00000364207.1 ENSMUSG00000141249 (from geneSymbol) uc338bhu.1 uc338bhu.1 
ENSMUST00000364210.1 ENSMUSG00000141250 ENSMUST00000364210.1 ENSMUSG00000141250 (from geneSymbol) uc338bhx.1 uc338bhx.1 
ENSMUST00000364211.1 ENSMUSG00000141251 ENSMUST00000364211.1 ENSMUSG00000141251 (from geneSymbol) uc338bhy.1 uc338bhy.1 
ENSMUST00000364212.1 ENSMUSG00000141252 ENSMUST00000364212.1 ENSMUSG00000141252 (from geneSymbol) uc338bhz.1 uc338bhz.1 
ENSMUST00000364213.1 ENSMUSG00000141253 ENSMUST00000364213.1 ENSMUSG00000141253 (from geneSymbol) uc338bia.1 uc338bia.1 
ENSMUST00000364214.1 ENSMUSG00000141254 ENSMUST00000364214.1 ENSMUSG00000141254 (from geneSymbol) uc338bib.1 uc338bib.1 
ENSMUST00000364215.1 ENSMUSG00000141255 ENSMUST00000364215.1 ENSMUSG00000141255 (from geneSymbol) uc338bic.1 uc338bic.1 
ENSMUST00000364218.1 Gm16267 ENSMUST00000364218.1 Gm16267 (from geneSymbol) uc338bif.1 uc338bif.1 
ENSMUST00000364219.1 ENSMUSG00000141256 ENSMUST00000364219.1 ENSMUSG00000141256 (from geneSymbol) uc338big.1 uc338big.1 
ENSMUST00000364220.1 ENSMUSG00000141257 ENSMUST00000364220.1 ENSMUSG00000141257 (from geneSymbol) uc338bih.1 uc338bih.1 
ENSMUST00000364225.1 ENSMUSG00000141258 ENSMUST00000364225.1 ENSMUSG00000141258 (from geneSymbol) uc338bim.1 uc338bim.1 
ENSMUST00000364226.1 ENSMUSG00000141259 ENSMUST00000364226.1 ENSMUSG00000141259 (from geneSymbol) AK010824 uc338bin.1 uc338bin.1 
ENSMUST00000364229.1 ENSMUSG00000141260 ENSMUST00000364229.1 ENSMUSG00000141260 (from geneSymbol) uc338biq.1 uc338biq.1 
ENSMUST00000364239.1 ENSMUSG00000141261 ENSMUST00000364239.1 ENSMUSG00000141261 (from geneSymbol) uc338bja.1 uc338bja.1 
ENSMUST00000364240.1 Cirbil ENSMUST00000364240.1 Cirbil (from geneSymbol) uc338bjb.1 uc338bjb.1 
ENSMUST00000364245.1 ENSMUSG00000141262 ENSMUST00000364245.1 ENSMUSG00000141262 (from geneSymbol) uc338bjg.1 uc338bjg.1 
ENSMUST00000364251.1 ENSMUSG00000141263 ENSMUST00000364251.1 ENSMUSG00000141263 (from geneSymbol) uc338bjm.1 uc338bjm.1 
ENSMUST00000364257.1 ENSMUSG00000141264 ENSMUST00000364257.1 ENSMUSG00000141264 (from geneSymbol) uc338bjs.1 uc338bjs.1 
ENSMUST00000364272.1 ENSMUSG00000141265 ENSMUST00000364272.1 ENSMUSG00000141265 (from geneSymbol) uc338bkh.1 uc338bkh.1 
ENSMUST00000364277.1 ENSMUSG00000141266 ENSMUST00000364277.1 ENSMUSG00000141266 (from geneSymbol) uc338bkl.1 uc338bkl.1 
ENSMUST00000364278.1 ENSMUSG00000141267 ENSMUST00000364278.1 ENSMUSG00000141267 (from geneSymbol) uc338bkm.1 uc338bkm.1 
ENSMUST00000364280.1 Gm28119 ENSMUST00000364280.1 Gm28119 (from geneSymbol) DM010973 uc338bko.1 uc338bko.1 
ENSMUST00000364281.1 ENSMUSG00000141268 ENSMUST00000364281.1 ENSMUSG00000141268 (from geneSymbol) uc338bkp.1 uc338bkp.1 
ENSMUST00000364283.1 Gm30781 ENSMUST00000364283.1 Gm30781 (from geneSymbol) uc338bkq.1 uc338bkq.1 
ENSMUST00000364298.1 ENSMUSG00000141269 ENSMUST00000364298.1 ENSMUSG00000141269 (from geneSymbol) uc338blf.1 uc338blf.1 
ENSMUST00000364300.1 ENSMUSG00000141270 ENSMUST00000364300.1 ENSMUSG00000141270 (from geneSymbol) uc338blh.1 uc338blh.1 
ENSMUST00000364301.1 ENSMUSG00000141271 ENSMUST00000364301.1 ENSMUSG00000141271 (from geneSymbol) uc338bli.1 uc338bli.1 
ENSMUST00000364304.1 ENSMUSG00000141272 ENSMUST00000364304.1 ENSMUSG00000141272 (from geneSymbol) uc338bll.1 uc338bll.1 
ENSMUST00000364305.1 ENSMUSG00000141273 ENSMUST00000364305.1 ENSMUSG00000141273 (from geneSymbol) uc338blm.1 uc338blm.1 
ENSMUST00000364307.1 ENSMUSG00000141274 ENSMUST00000364307.1 ENSMUSG00000141274 (from geneSymbol) uc338blo.1 uc338blo.1 
ENSMUST00000364308.1 ENSMUSG00000141275 ENSMUST00000364308.1 ENSMUSG00000141275 (from geneSymbol) uc338blp.1 uc338blp.1 
ENSMUST00000364310.1 ENSMUSG00000141276 ENSMUST00000364310.1 ENSMUSG00000141276 (from geneSymbol) uc338blr.1 uc338blr.1 
ENSMUST00000364311.1 ENSMUSG00000141277 ENSMUST00000364311.1 ENSMUSG00000141277 (from geneSymbol) uc338bls.1 uc338bls.1 
ENSMUST00000364332.1 ENSMUSG00000141278 ENSMUST00000364332.1 ENSMUSG00000141278 (from geneSymbol) uc338bmn.1 uc338bmn.1 
ENSMUST00000364333.1 ENSMUSG00000141279 ENSMUST00000364333.1 ENSMUSG00000141279 (from geneSymbol) uc338bmo.1 uc338bmo.1 
ENSMUST00000364334.1 Erdr1y ENSMUST00000364334.1 Erdr1y (from geneSymbol) AK051407 uc338bmp.1 uc338bmp.1 
ENSMUST00000364363.1 ENSMUSG00000141280 ENSMUST00000364363.1 ENSMUSG00000141280 (from geneSymbol) uc338bns.1 uc338bns.1 
ENSMUST00000364364.1 ENSMUSG00000141281 ENSMUST00000364364.1 ENSMUSG00000141281 (from geneSymbol) uc338bnt.1 uc338bnt.1 
ENSMUST00000364369.1 ENSMUSG00000141282 ENSMUST00000364369.1 ENSMUSG00000141282 (from geneSymbol) uc338bny.1 uc338bny.1 
ENSMUST00000364376.1 ENSMUSG00000141283 ENSMUST00000364376.1 ENSMUSG00000141283 (from geneSymbol) uc338bof.1 uc338bof.1 
ENSMUST00000364380.1 Gm47889 ENSMUST00000364380.1 Gm47889 (from geneSymbol) AK087030 uc338boi.1 uc338boi.1 
ENSMUST00000364386.1 ENSMUSG00000141284 ENSMUST00000364386.1 ENSMUSG00000141284 (from geneSymbol) uc338boo.1 uc338boo.1 
ENSMUST00000364388.1 ENSMUSG00000141285 ENSMUST00000364388.1 ENSMUSG00000141285 (from geneSymbol) uc338boq.1 uc338boq.1 
ENSMUST00000364395.1 ENSMUSG00000141286 ENSMUST00000364395.1 ENSMUSG00000141286 (from geneSymbol) uc338box.1 uc338box.1 
ENSMUST00000364396.1 ENSMUSG00000141287 ENSMUST00000364396.1 ENSMUSG00000141287 (from geneSymbol) uc338boy.1 uc338boy.1 
ENSMUST00000364397.1 ENSMUSG00000141288 ENSMUST00000364397.1 ENSMUSG00000141288 (from geneSymbol) uc338boz.1 uc338boz.1 
ENSMUST00000364412.1 Gm56941 ENSMUST00000364412.1 Gm56941 (from geneSymbol) uc338bpo.1 uc338bpo.1 
ENSMUST00000364419.1 ENSMUSG00000141289 ENSMUST00000364419.1 ENSMUSG00000141289 (from geneSymbol) uc338bpv.1 uc338bpv.1 
ENSMUST00000364427.1 ENSMUSG00000141290 ENSMUST00000364427.1 ENSMUSG00000141290 (from geneSymbol) uc338bqd.1 uc338bqd.1 
ENSMUST00000364434.1 Gm6069 ENSMUST00000364434.1 Gm6069 (from geneSymbol) uc338bqk.1 uc338bqk.1 
ENSMUST00000364443.1 ENSMUSG00000141292 ENSMUST00000364443.1 ENSMUSG00000141292 (from geneSymbol) uc338bqt.1 uc338bqt.1 
ENSMUST00000364447.1 ENSMUSG00000141293 ENSMUST00000364447.1 ENSMUSG00000141293 (from geneSymbol) uc338bqx.1 uc338bqx.1 
ENSMUST00000364448.1 ENSMUSG00000141294 ENSMUST00000364448.1 ENSMUSG00000141294 (from geneSymbol) uc338bqy.1 uc338bqy.1 
ENSMUST00000364449.1 ENSMUSG00000141295 ENSMUST00000364449.1 ENSMUSG00000141295 (from geneSymbol) uc338bqz.1 uc338bqz.1 
ENSMUST00000364451.1 ENSMUSG00000141296 ENSMUST00000364451.1 ENSMUSG00000141296 (from geneSymbol) uc338brb.1 uc338brb.1 
ENSMUST00000364456.1 ENSMUSG00000141297 ENSMUST00000364456.1 ENSMUSG00000141297 (from geneSymbol) uc338brg.1 uc338brg.1 
ENSMUST00000364457.1 ENSMUSG00000141298 ENSMUST00000364457.1 ENSMUSG00000141298 (from geneSymbol) uc338brh.1 uc338brh.1 
ENSMUST00000364458.1 ENSMUSG00000141299 ENSMUST00000364458.1 ENSMUSG00000141299 (from geneSymbol) uc338bri.1 uc338bri.1 
ENSMUST00000364459.1 ENSMUSG00000141300 ENSMUST00000364459.1 ENSMUSG00000141300 (from geneSymbol) uc338brj.1 uc338brj.1 
ENSMUST00000364465.1 4930555K05Rik ENSMUST00000364465.1 RIKEN cDNA 4930555K05 gene (from RefSeq NR_126459.1) NR_126459 uc338brp.1 uc338brp.1 
ENSMUST00000364468.1 ENSMUSG00000141302 ENSMUST00000364468.1 ENSMUSG00000141302 (from geneSymbol) uc338brs.1 uc338brs.1 
ENSMUST00000364469.1 ENSMUSG00000141303 ENSMUST00000364469.1 ENSMUSG00000141303 (from geneSymbol) uc338brt.1 uc338brt.1 
ENSMUST00000364472.1 ENSMUSG00000141304 ENSMUST00000364472.1 ENSMUSG00000141304 (from geneSymbol) uc338brw.1 uc338brw.1 
ENSMUST00000364493.1 ENSMUSG00000141305 ENSMUST00000364493.1 ENSMUSG00000141305 (from geneSymbol) uc338bsr.1 uc338bsr.1 
ENSMUST00000364494.1 ENSMUSG00000141306 ENSMUST00000364494.1 ENSMUSG00000141306 (from geneSymbol) uc338bss.1 uc338bss.1 
ENSMUST00000364495.1 ENSMUSG00000141307 ENSMUST00000364495.1 ENSMUSG00000141307 (from geneSymbol) uc338bst.1 uc338bst.1 
ENSMUST00000364496.1 ENSMUSG00000141308 ENSMUST00000364496.1 ENSMUSG00000141308 (from geneSymbol) uc338bsu.1 uc338bsu.1 
ENSMUST00000364497.1 Gimap1os ENSMUST00000364497.1 Gimap1os (from geneSymbol) uc338bsv.1 uc338bsv.1 
ENSMUST00000364498.1 ENSMUSG00000141309 ENSMUST00000364498.1 ENSMUSG00000141309 (from geneSymbol) AK047520 uc338bsw.1 uc338bsw.1 
ENSMUST00000364501.1 Gm28979 ENSMUST00000364501.1 Gm28979 (from geneSymbol) uc338bsz.1 uc338bsz.1 
ENSMUST00000364503.1 ENSMUSG00000141310 ENSMUST00000364503.1 ENSMUSG00000141310 (from geneSymbol) uc338btb.1 uc338btb.1 
ENSMUST00000364508.1 ENSMUSG00000141311 ENSMUST00000364508.1 ENSMUSG00000141311 (from geneSymbol) uc338btg.1 uc338btg.1 
ENSMUST00000364509.1 ENSMUSG00000141312 ENSMUST00000364509.1 ENSMUSG00000141312 (from geneSymbol) uc338bth.1 uc338bth.1 
ENSMUST00000364510.1 ENSMUSG00000141313 ENSMUST00000364510.1 ENSMUSG00000141313 (from geneSymbol) uc338bti.1 uc338bti.1 
ENSMUST00000364512.1 ENSMUSG00000141314 ENSMUST00000364512.1 ENSMUSG00000141314 (from geneSymbol) uc338btj.1 uc338btj.1 
ENSMUST00000364549.1 ENSMUSG00000141315 ENSMUST00000364549.1 ENSMUSG00000141315 (from geneSymbol) uc338but.1 uc338but.1 
ENSMUST00000364550.1 ENSMUSG00000141316 ENSMUST00000364550.1 ENSMUSG00000141316 (from geneSymbol) uc338buu.1 uc338buu.1 
ENSMUST00000364553.1 ENSMUSG00000141317 ENSMUST00000364553.1 ENSMUSG00000141317 (from geneSymbol) uc338bux.1 uc338bux.1 
ENSMUST00000364554.1 ENSMUSG00000141318 ENSMUST00000364554.1 ENSMUSG00000141318 (from geneSymbol) uc338buy.1 uc338buy.1 
ENSMUST00000364576.1 ENSMUSG00000141319 ENSMUST00000364576.1 ENSMUSG00000141319 (from geneSymbol) uc338bvu.1 uc338bvu.1 
ENSMUST00000364580.1 ENSMUSG00000141320 ENSMUST00000364580.1 ENSMUSG00000141320 (from geneSymbol) uc338bvy.1 uc338bvy.1 
ENSMUST00000364583.1 ENSMUSG00000141322 ENSMUST00000364583.1 ENSMUSG00000141322 (from geneSymbol) uc338bvz.1 uc338bvz.1 
ENSMUST00000364594.1 ENSMUSG00000141323 ENSMUST00000364594.1 ENSMUSG00000141323 (from geneSymbol) uc338bwk.1 uc338bwk.1 
ENSMUST00000364595.1 Gm12167 ENSMUST00000364595.1 Gm12167 (from geneSymbol) uc338bwl.1 uc338bwl.1 
ENSMUST00000364596.1 ENSMUSG00000141324 ENSMUST00000364596.1 ENSMUSG00000141324 (from geneSymbol) uc338bwm.1 uc338bwm.1 
ENSMUST00000364598.1 ENSMUSG00000141325 ENSMUST00000364598.1 ENSMUSG00000141325 (from geneSymbol) uc338bwo.1 uc338bwo.1 
ENSMUST00000364600.1 ENSMUSG00000141326 ENSMUST00000364600.1 ENSMUSG00000141326 (from geneSymbol) uc338bwq.1 uc338bwq.1 
ENSMUST00000364601.1 ENSMUSG00000141327 ENSMUST00000364601.1 ENSMUSG00000141327 (from geneSymbol) uc338bwr.1 uc338bwr.1 
ENSMUST00000364610.1 Gm11608 ENSMUST00000364610.1 Gm11608 (from geneSymbol) uc338bxa.1 uc338bxa.1 
ENSMUST00000364633.1 ENSMUSG00000141328 ENSMUST00000364633.1 ENSMUSG00000141328 (from geneSymbol) uc338bxx.1 uc338bxx.1 
ENSMUST00000364636.1 1700095K22Rik ENSMUST00000364636.1 1700095K22Rik (from geneSymbol) uc338bya.1 uc338bya.1 
ENSMUST00000364640.1 ENSMUSG00000141329 ENSMUST00000364640.1 ENSMUSG00000141329 (from geneSymbol) uc338bye.1 uc338bye.1 
ENSMUST00000364654.1 ENSMUSG00000141330 ENSMUST00000364654.1 ENSMUSG00000141330 (from geneSymbol) uc338bys.1 uc338bys.1 
ENSMUST00000364655.1 ENSMUSG00000141331 ENSMUST00000364655.1 ENSMUSG00000141331 (from geneSymbol) uc338byt.1 uc338byt.1 
ENSMUST00000364656.1 ENSMUSG00000141332 ENSMUST00000364656.1 ENSMUSG00000141332 (from geneSymbol) uc338byu.1 uc338byu.1 
ENSMUST00000364663.1 ENSMUSG00000141333 ENSMUST00000364663.1 ENSMUSG00000141333 (from geneSymbol) uc338bzb.1 uc338bzb.1 
ENSMUST00000364664.1 ENSMUSG00000141334 ENSMUST00000364664.1 ENSMUSG00000141334 (from geneSymbol) uc338bzc.1 uc338bzc.1 
ENSMUST00000364665.1 ENSMUSG00000141335 ENSMUST00000364665.1 ENSMUSG00000141335 (from geneSymbol) uc338bzd.1 uc338bzd.1 
ENSMUST00000364667.1 ENSMUSG00000141336 ENSMUST00000364667.1 ENSMUSG00000141336 (from geneSymbol) uc338bzf.1 uc338bzf.1 
ENSMUST00000364668.1 1700052H01Rik ENSMUST00000364668.1 1700052H01Rik (from geneSymbol) AK006766 uc338bzg.1 uc338bzg.1 
ENSMUST00000364685.1 ENSMUSG00000141337 ENSMUST00000364685.1 ENSMUSG00000141337 (from geneSymbol) uc338bzx.1 uc338bzx.1 
ENSMUST00000364686.1 ENSMUSG00000141338 ENSMUST00000364686.1 ENSMUSG00000141338 (from geneSymbol) uc338bzy.1 uc338bzy.1 
ENSMUST00000364691.1 ENSMUSG00000141339 ENSMUST00000364691.1 ENSMUSG00000141339 (from geneSymbol) uc338cad.1 uc338cad.1 
ENSMUST00000364693.1 ENSMUSG00000141340 ENSMUST00000364693.1 ENSMUSG00000141340 (from geneSymbol) uc338caf.1 uc338caf.1 
ENSMUST00000364694.1 ENSMUSG00000141341 ENSMUST00000364694.1 ENSMUSG00000141341 (from geneSymbol) uc338cag.1 uc338cag.1 
ENSMUST00000364700.1 ENSMUSG00000141342 ENSMUST00000364700.1 ENSMUSG00000141342 (from geneSymbol) uc338cam.1 uc338cam.1 
ENSMUST00000364701.1 ENSMUSG00000141343 ENSMUST00000364701.1 ENSMUSG00000141343 (from geneSymbol) uc338can.1 uc338can.1 
ENSMUST00000364705.1 ENSMUSG00000141344 ENSMUST00000364705.1 ENSMUSG00000141344 (from geneSymbol) uc338car.1 uc338car.1 
ENSMUST00000364706.1 ENSMUSG00000141345 ENSMUST00000364706.1 ENSMUSG00000141345 (from geneSymbol) uc338cas.1 uc338cas.1 
ENSMUST00000364717.1 4930547E14Rik ENSMUST00000364717.1 4930547E14Rik (from geneSymbol) AK016054 uc338cbd.1 uc338cbd.1 
ENSMUST00000364731.1 ENSMUSG00000141346 ENSMUST00000364731.1 ENSMUSG00000141346 (from geneSymbol) uc338cbr.1 uc338cbr.1 
ENSMUST00000364733.1 ENSMUSG00000141347 ENSMUST00000364733.1 ENSMUSG00000141347 (from geneSymbol) uc338cbt.1 uc338cbt.1 
ENSMUST00000364735.1 ENSMUSG00000141348 ENSMUST00000364735.1 ENSMUSG00000141348 (from geneSymbol) uc338cbv.1 uc338cbv.1 
ENSMUST00000364737.1 ENSMUSG00000141349 ENSMUST00000364737.1 ENSMUSG00000141349 (from geneSymbol) uc338cbx.1 uc338cbx.1 
ENSMUST00000364742.1 ENSMUSG00000141350 ENSMUST00000364742.1 ENSMUSG00000141350 (from geneSymbol) uc338ccc.1 uc338ccc.1 
ENSMUST00000364745.1 ENSMUSG00000141351 ENSMUST00000364745.1 ENSMUSG00000141351 (from geneSymbol) uc338ccf.1 uc338ccf.1 
ENSMUST00000364746.1 Gm35986 ENSMUST00000364746.1 Gm35986 (from geneSymbol) uc338ccg.1 uc338ccg.1 
ENSMUST00000364756.1 ENSMUSG00000141352 ENSMUST00000364756.1 ENSMUSG00000141352 (from geneSymbol) uc338ccq.1 uc338ccq.1 
ENSMUST00000364760.1 ENSMUSG00000141353 ENSMUST00000364760.1 ENSMUSG00000141353 (from geneSymbol) uc338ccu.1 uc338ccu.1 
ENSMUST00000364762.1 ENSMUSG00000141354 ENSMUST00000364762.1 ENSMUSG00000141354 (from geneSymbol) uc338ccw.1 uc338ccw.1 
ENSMUST00000364763.1 ENSMUSG00000141355 ENSMUST00000364763.1 ENSMUSG00000141355 (from geneSymbol) uc338ccx.1 uc338ccx.1 
ENSMUST00000364764.1 ENSMUSG00000141356 ENSMUST00000364764.1 ENSMUSG00000141356 (from geneSymbol) uc338ccy.1 uc338ccy.1 
ENSMUST00000364774.1 ENSMUSG00000141357 ENSMUST00000364774.1 ENSMUSG00000141357 (from geneSymbol) uc338cdi.1 uc338cdi.1 
ENSMUST00000364776.1 ENSMUSG00000141358 ENSMUST00000364776.1 ENSMUSG00000141358 (from geneSymbol) uc338cdk.1 uc338cdk.1 
ENSMUST00000364777.1 Gm45056 ENSMUST00000364777.1 Gm45056 (from geneSymbol) uc338cdl.1 uc338cdl.1 
ENSMUST00000364778.1 ENSMUSG00000141359 ENSMUST00000364778.1 ENSMUSG00000141359 (from geneSymbol) uc338cdm.1 uc338cdm.1 
ENSMUST00000364780.1 ENSMUSG00000141360 ENSMUST00000364780.1 ENSMUSG00000141360 (from geneSymbol) uc338cdo.1 uc338cdo.1 
ENSMUST00000364781.1 ENSMUSG00000141361 ENSMUST00000364781.1 ENSMUSG00000141361 (from geneSymbol) uc338cdp.1 uc338cdp.1 
ENSMUST00000364782.1 ENSMUSG00000141362 ENSMUST00000364782.1 ENSMUSG00000141362 (from geneSymbol) uc338cdq.1 uc338cdq.1 
ENSMUST00000364786.1 Gm57061 ENSMUST00000364786.1 Gm57061 (from geneSymbol) uc338cdu.1 uc338cdu.1 
ENSMUST00000364787.1 ENSMUSG00000141363 ENSMUST00000364787.1 ENSMUSG00000141363 (from geneSymbol) uc338cdv.1 uc338cdv.1 
ENSMUST00000364790.1 ENSMUSG00000141364 ENSMUST00000364790.1 ENSMUSG00000141364 (from geneSymbol) uc338cdy.1 uc338cdy.1 
ENSMUST00000364791.1 ENSMUSG00000141365 ENSMUST00000364791.1 ENSMUSG00000141365 (from geneSymbol) uc338cdz.1 uc338cdz.1 
ENSMUST00000364793.1 ENSMUSG00000141366 ENSMUST00000364793.1 ENSMUSG00000141366 (from geneSymbol) uc338ceb.1 uc338ceb.1 
ENSMUST00000364796.1 4933416E03Rik ENSMUST00000364796.1 4933416E03Rik (from geneSymbol) AK016829 uc338cee.1 uc338cee.1 
ENSMUST00000364813.1 Gm44581 ENSMUST00000364813.1 Gm44581 (from geneSymbol) uc338cev.1 uc338cev.1 
ENSMUST00000364819.1 ENSMUSG00000141367 ENSMUST00000364819.1 ENSMUSG00000141367 (from geneSymbol) uc338cfa.1 uc338cfa.1 
ENSMUST00000364826.1 ENSMUSG00000141368 ENSMUST00000364826.1 ENSMUSG00000141368 (from geneSymbol) uc338cfh.1 uc338cfh.1 
ENSMUST00000364833.1 ENSMUSG00000141369 ENSMUST00000364833.1 ENSMUSG00000141369 (from geneSymbol) uc338cfo.1 uc338cfo.1 
ENSMUST00000364836.1 ENSMUSG00000141370 ENSMUST00000364836.1 ENSMUSG00000141370 (from geneSymbol) uc338cfr.1 uc338cfr.1 
ENSMUST00000364839.1 ENSMUSG00000141371 ENSMUST00000364839.1 ENSMUSG00000141371 (from geneSymbol) uc338cfu.1 uc338cfu.1 
ENSMUST00000364841.1 ENSMUSG00000141372 ENSMUST00000364841.1 ENSMUSG00000141372 (from geneSymbol) uc338cfw.1 uc338cfw.1 
ENSMUST00000364842.1 6430590A07Rik ENSMUST00000364842.1 6430590A07Rik (from geneSymbol) AK078307 uc338cfx.1 uc338cfx.1 
ENSMUST00000364843.1 Gm5907 ENSMUST00000364843.1 Gm5907 (from geneSymbol) AK145481 uc338cfy.1 uc338cfy.1 
ENSMUST00000364853.1 ENSMUSG00000141373 ENSMUST00000364853.1 ENSMUSG00000141373 (from geneSymbol) LF293614 uc338cgi.1 uc338cgi.1 
ENSMUST00000364855.1 ENSMUSG00000141375 ENSMUST00000364855.1 ENSMUSG00000141375 (from geneSymbol) uc338cgj.1 uc338cgj.1 
ENSMUST00000364857.1 ENSMUSG00000141376 ENSMUST00000364857.1 ENSMUSG00000141376 (from geneSymbol) uc338cgl.1 uc338cgl.1 
ENSMUST00000364858.1 ENSMUSG00000141377 ENSMUST00000364858.1 ENSMUSG00000141377 (from geneSymbol) uc338cgm.1 uc338cgm.1 
ENSMUST00000364859.1 ENSMUSG00000141378 ENSMUST00000364859.1 ENSMUSG00000141378 (from geneSymbol) uc338cgn.1 uc338cgn.1 
ENSMUST00000364860.1 ENSMUSG00000141379 ENSMUST00000364860.1 ENSMUSG00000141379 (from geneSymbol) uc338cgo.1 uc338cgo.1 
ENSMUST00000364862.1 Gm4013 ENSMUST00000364862.1 Gm4013 (from geneSymbol) KY467804 uc338cgq.1 uc338cgq.1 
ENSMUST00000364875.1 ENSMUSG00000141380 ENSMUST00000364875.1 ENSMUSG00000141380 (from geneSymbol) uc338chd.1 uc338chd.1 
ENSMUST00000364876.1 ENSMUSG00000141381 ENSMUST00000364876.1 ENSMUSG00000141381 (from geneSymbol) uc338che.1 uc338che.1 
ENSMUST00000364877.1 Gm10032 ENSMUST00000364877.1 Gm10032 (from geneSymbol) AK040737 uc338chf.1 uc338chf.1 
ENSMUST00000364878.1 4930566F21Rik ENSMUST00000364878.1 4930566F21Rik (from geneSymbol) AK016234 uc338chg.1 uc338chg.1 
ENSMUST00000364889.1 ENSMUSG00000141382 ENSMUST00000364889.1 ENSMUSG00000141382 (from geneSymbol) uc338chr.1 uc338chr.1 
ENSMUST00000364893.1 ENSMUSG00000141383 ENSMUST00000364893.1 ENSMUSG00000141383 (from geneSymbol) uc338chv.1 uc338chv.1 
ENSMUST00000364897.1 ENSMUSG00000141384 ENSMUST00000364897.1 ENSMUSG00000141384 (from geneSymbol) uc338chz.1 uc338chz.1 
ENSMUST00000364900.1 ENSMUSG00000141385 ENSMUST00000364900.1 ENSMUSG00000141385 (from geneSymbol) uc338cic.1 uc338cic.1 
ENSMUST00000364902.1 ENSMUSG00000141386 ENSMUST00000364902.1 ENSMUSG00000141386 (from geneSymbol) uc338cie.1 uc338cie.1 
ENSMUST00000364907.1 ENSMUSG00000141387 ENSMUST00000364907.1 ENSMUSG00000141387 (from geneSymbol) uc338cij.1 uc338cij.1 
ENSMUST00000364914.1 Gm32618 ENSMUST00000364914.1 Gm32618 (from geneSymbol) BC089548 uc338cio.1 uc338cio.1 
ENSMUST00000364926.1 ENSMUSG00000141388 ENSMUST00000364926.1 ENSMUSG00000141388 (from geneSymbol) uc338cja.1 uc338cja.1 
ENSMUST00000364927.1 ENSMUSG00000141389 ENSMUST00000364927.1 ENSMUSG00000141389 (from geneSymbol) uc338cjb.1 uc338cjb.1 
ENSMUST00000364928.1 ENSMUSG00000141390 ENSMUST00000364928.1 ENSMUSG00000141390 (from geneSymbol) uc338cjc.1 uc338cjc.1 
ENSMUST00000364937.1 Gm14267 ENSMUST00000364937.1 Gm14267 (from geneSymbol) uc338cjl.1 uc338cjl.1 
ENSMUST00000364952.1 ENSMUSG00000141391 ENSMUST00000364952.1 ENSMUSG00000141391 (from geneSymbol) uc338cka.1 uc338cka.1 
ENSMUST00000364957.1 ENSMUSG00000141392 ENSMUST00000364957.1 ENSMUSG00000141392 (from geneSymbol) uc338ckf.1 uc338ckf.1 
ENSMUST00000364958.1 ENSMUSG00000141393 ENSMUST00000364958.1 ENSMUSG00000141393 (from geneSymbol) uc338ckg.1 uc338ckg.1 
ENSMUST00000364961.1 ENSMUSG00000141394 ENSMUST00000364961.1 ENSMUSG00000141394 (from geneSymbol) uc338ckj.1 uc338ckj.1 
ENSMUST00000364962.1 ENSMUSG00000141395 ENSMUST00000364962.1 ENSMUSG00000141395 (from geneSymbol) uc338ckk.1 uc338ckk.1 
ENSMUST00000364964.1 ENSMUSG00000141396 ENSMUST00000364964.1 ENSMUSG00000141396 (from geneSymbol) uc338ckm.1 uc338ckm.1 
ENSMUST00000364987.1 ENSMUSG00000141397 ENSMUST00000364987.1 ENSMUSG00000141397 (from geneSymbol) uc338clj.1 uc338clj.1 
ENSMUST00000364988.1 ENSMUSG00000141398 ENSMUST00000364988.1 ENSMUSG00000141398 (from geneSymbol) uc338clk.1 uc338clk.1 
ENSMUST00000364989.1 ENSMUSG00000141399 ENSMUST00000364989.1 ENSMUSG00000141399 (from geneSymbol) uc338cll.1 uc338cll.1 
ENSMUST00000364996.1 Gm37035 ENSMUST00000364996.1 Gm37035 (from geneSymbol) uc338cln.1 uc338cln.1 
ENSMUST00000365069.1 ENSMUSG00000141401 ENSMUST00000365069.1 ENSMUSG00000141401 (from geneSymbol) uc338coi.1 uc338coi.1 
ENSMUST00000365070.1 C430014B12Rik ENSMUST00000365070.1 C430014B12Rik (from geneSymbol) AK043693 uc338coj.1 uc338coj.1 
ENSMUST00000365075.1 ENSMUSG00000141402 ENSMUST00000365075.1 ENSMUSG00000141402 (from geneSymbol) uc338coo.1 uc338coo.1 
ENSMUST00000365076.1 4930519F24Rik ENSMUST00000365076.1 4930519F24Rik (from geneSymbol) AK076865 uc338cop.1 uc338cop.1 
ENSMUST00000365089.1 ENSMUSG00000141403 ENSMUST00000365089.1 ENSMUSG00000141403 (from geneSymbol) uc338cpc.1 uc338cpc.1 
ENSMUST00000365091.1 ENSMUSG00000141405 ENSMUST00000365091.1 ENSMUSG00000141405 (from geneSymbol) uc338cpd.1 uc338cpd.1 
ENSMUST00000365092.1 ENSMUSG00000141406 ENSMUST00000365092.1 ENSMUSG00000141406 (from geneSymbol) uc338cpe.1 uc338cpe.1 
ENSMUST00000365093.1 ENSMUSG00000141407 ENSMUST00000365093.1 ENSMUSG00000141407 (from geneSymbol) uc338cpf.1 uc338cpf.1 
ENSMUST00000365097.1 ENSMUSG00000141408 ENSMUST00000365097.1 ENSMUSG00000141408 (from geneSymbol) uc338cpj.1 uc338cpj.1 
ENSMUST00000365099.1 ENSMUSG00000141409 ENSMUST00000365099.1 ENSMUSG00000141409 (from geneSymbol) uc338cpl.1 uc338cpl.1 
ENSMUST00000365100.1 ENSMUSG00000141410 ENSMUST00000365100.1 ENSMUSG00000141410 (from geneSymbol) uc338cpm.1 uc338cpm.1 
ENSMUST00000365101.1 ENSMUSG00000141411 ENSMUST00000365101.1 ENSMUSG00000141411 (from geneSymbol) KY467599 uc338cpn.1 uc338cpn.1 
ENSMUST00000365103.1 ENSMUSG00000141412 ENSMUST00000365103.1 ENSMUSG00000141412 (from geneSymbol) uc338cpp.1 uc338cpp.1 
ENSMUST00000365105.1 ENSMUSG00000141413 ENSMUST00000365105.1 ENSMUSG00000141413 (from geneSymbol) uc338cpr.1 uc338cpr.1 
ENSMUST00000365107.1 ENSMUSG00000141414 ENSMUST00000365107.1 ENSMUSG00000141414 (from geneSymbol) uc338cpt.1 uc338cpt.1 
ENSMUST00000365138.1 ENSMUSG00000141415 ENSMUST00000365138.1 ENSMUSG00000141415 (from geneSymbol) DQ695279 uc338cqy.1 uc338cqy.1 
ENSMUST00000365140.1 ENSMUSG00000141416 ENSMUST00000365140.1 ENSMUSG00000141416 (from geneSymbol) uc338cra.1 uc338cra.1 
ENSMUST00000365142.1 ENSMUSG00000141417 ENSMUST00000365142.1 ENSMUSG00000141417 (from geneSymbol) uc338crc.1 uc338crc.1 
ENSMUST00000365147.1 ENSMUSG00000141418 ENSMUST00000365147.1 ENSMUSG00000141418 (from geneSymbol) uc338crh.1 uc338crh.1 
ENSMUST00000365149.1 ENSMUSG00000141419 ENSMUST00000365149.1 ENSMUSG00000141419 (from geneSymbol) uc338crj.1 uc338crj.1 
ENSMUST00000365150.1 ENSMUSG00000141420 ENSMUST00000365150.1 ENSMUSG00000141420 (from geneSymbol) uc338crk.1 uc338crk.1 
ENSMUST00000365152.1 Gm44077 ENSMUST00000365152.1 Gm44077 (from geneSymbol) uc338crm.1 uc338crm.1 
ENSMUST00000365160.1 ENSMUSG00000141421 ENSMUST00000365160.1 ENSMUSG00000141421 (from geneSymbol) uc338cru.1 uc338cru.1 
ENSMUST00000365161.1 Gm26760 ENSMUST00000365161.1 Gm26760 (from geneSymbol) KY467734 uc338crv.1 uc338crv.1 
ENSMUST00000365188.1 ENSMUSG00000141422 ENSMUST00000365188.1 ENSMUSG00000141422 (from geneSymbol) uc338csw.1 uc338csw.1 
ENSMUST00000365191.1 ENSMUSG00000141423 ENSMUST00000365191.1 ENSMUSG00000141423 (from geneSymbol) uc338csz.1 uc338csz.1 
ENSMUST00000365192.1 ENSMUSG00000141424 ENSMUST00000365192.1 ENSMUSG00000141424 (from geneSymbol) uc338cta.1 uc338cta.1 
ENSMUST00000365193.1 ENSMUSG00000141425 ENSMUST00000365193.1 ENSMUSG00000141425 (from geneSymbol) uc338ctb.1 uc338ctb.1 
ENSMUST00000365194.1 ENSMUSG00000141426 ENSMUST00000365194.1 ENSMUSG00000141426 (from geneSymbol) uc338ctc.1 uc338ctc.1 
ENSMUST00000365196.1 ENSMUSG00000141427 ENSMUST00000365196.1 ENSMUSG00000141427 (from geneSymbol) uc338cte.1 uc338cte.1 
ENSMUST00000365197.1 ENSMUSG00000141428 ENSMUST00000365197.1 ENSMUSG00000141428 (from geneSymbol) uc338ctf.1 uc338ctf.1 
ENSMUST00000365199.1 ENSMUSG00000141429 ENSMUST00000365199.1 ENSMUSG00000141429 (from geneSymbol) uc338cth.1 uc338cth.1 
ENSMUST00000365205.1 ENSMUSG00000141430 ENSMUST00000365205.1 ENSMUSG00000141430 (from geneSymbol) uc338ctn.1 uc338ctn.1 
ENSMUST00000365229.1 ENSMUSG00000141431 ENSMUST00000365229.1 ENSMUSG00000141431 (from geneSymbol) uc338cul.1 uc338cul.1 
ENSMUST00000365232.1 Gm41289 ENSMUST00000365232.1 Gm41289 (from geneSymbol) AK029646 uc338cuo.1 uc338cuo.1 
ENSMUST00000365241.1 ENSMUSG00000141432 ENSMUST00000365241.1 ENSMUSG00000141432 (from geneSymbol) uc338cux.1 uc338cux.1 
ENSMUST00000365244.1 ENSMUSG00000141433 ENSMUST00000365244.1 ENSMUSG00000141433 (from geneSymbol) uc338cva.1 uc338cva.1 
ENSMUST00000365245.1 ENSMUSG00000141434 ENSMUST00000365245.1 ENSMUSG00000141434 (from geneSymbol) uc338cvb.1 uc338cvb.1 
ENSMUST00000365246.1 ENSMUSG00000141435 ENSMUST00000365246.1 ENSMUSG00000141435 (from geneSymbol) uc338cvc.1 uc338cvc.1 
ENSMUST00000365247.1 Platr3 ENSMUST00000365247.1 Platr3 (from geneSymbol) KY467899 uc338cvd.1 uc338cvd.1 
ENSMUST00000365253.1 ENSMUSG00000141436 ENSMUST00000365253.1 ENSMUSG00000141436 (from geneSymbol) uc338cvj.1 uc338cvj.1 
ENSMUST00000365255.1 ENSMUSG00000141437 ENSMUST00000365255.1 ENSMUSG00000141437 (from geneSymbol) AK029833 uc338cvl.1 uc338cvl.1 
ENSMUST00000365260.1 ENSMUSG00000141438 ENSMUST00000365260.1 ENSMUSG00000141438 (from geneSymbol) uc338cvq.1 uc338cvq.1 
ENSMUST00000365262.1 ENSMUSG00000141439 ENSMUST00000365262.1 ENSMUSG00000141439 (from geneSymbol) uc338cvs.1 uc338cvs.1 
ENSMUST00000365264.1 ENSMUSG00000141440 ENSMUST00000365264.1 ENSMUSG00000141440 (from geneSymbol) uc338cvu.1 uc338cvu.1 
ENSMUST00000365268.1 ENSMUSG00000141441 ENSMUST00000365268.1 ENSMUSG00000141441 (from geneSymbol) uc338cvy.1 uc338cvy.1 
ENSMUST00000365269.1 ENSMUSG00000141442 ENSMUST00000365269.1 ENSMUSG00000141442 (from geneSymbol) uc338cvz.1 uc338cvz.1 
ENSMUST00000365270.1 Gm37584 ENSMUST00000365270.1 Gm37584 (from geneSymbol) uc338cwa.1 uc338cwa.1 
ENSMUST00000365276.1 ENSMUSG00000141444 ENSMUST00000365276.1 ENSMUSG00000141444 (from geneSymbol) uc338cwg.1 uc338cwg.1 
ENSMUST00000365277.1 ENSMUSG00000141445 ENSMUST00000365277.1 ENSMUSG00000141445 (from geneSymbol) uc338cwh.1 uc338cwh.1 
ENSMUST00000365278.1 Lrrc75aos1 ENSMUST00000365278.1 Lrrc75aos1 (from geneSymbol) AK019771 uc338cwi.1 uc338cwi.1 
ENSMUST00000365286.1 ENSMUSG00000141446 ENSMUST00000365286.1 ENSMUSG00000141446 (from geneSymbol) uc338cwq.1 uc338cwq.1 
ENSMUST00000365310.1 ENSMUSG00000141447 ENSMUST00000365310.1 ENSMUSG00000141447 (from geneSymbol) uc338cxo.1 uc338cxo.1 
ENSMUST00000365311.1 ENSMUSG00000141448 ENSMUST00000365311.1 ENSMUSG00000141448 (from geneSymbol) uc338cxp.1 uc338cxp.1 
ENSMUST00000365312.1 ENSMUSG00000141449 ENSMUST00000365312.1 ENSMUSG00000141449 (from geneSymbol) uc338cxq.1 uc338cxq.1 
ENSMUST00000365313.1 ENSMUSG00000141450 ENSMUST00000365313.1 ENSMUSG00000141450 (from geneSymbol) uc338cxr.1 uc338cxr.1 
ENSMUST00000365314.1 ENSMUSG00000141451 ENSMUST00000365314.1 ENSMUSG00000141451 (from geneSymbol) uc338cxs.1 uc338cxs.1 
ENSMUST00000365322.1 ENSMUSG00000141452 ENSMUST00000365322.1 ENSMUSG00000141452 (from geneSymbol) uc338cya.1 uc338cya.1 
ENSMUST00000365333.1 ENSMUSG00000141453 ENSMUST00000365333.1 ENSMUSG00000141453 (from geneSymbol) uc338cyl.1 uc338cyl.1 
ENSMUST00000365334.1 ENSMUSG00000141454 ENSMUST00000365334.1 ENSMUSG00000141454 (from geneSymbol) uc338cym.1 uc338cym.1 
ENSMUST00000365338.1 ENSMUSG00000141455 ENSMUST00000365338.1 ENSMUSG00000141455 (from geneSymbol) uc338cyq.1 uc338cyq.1 
ENSMUST00000365339.1 ENSMUSG00000141456 ENSMUST00000365339.1 ENSMUSG00000141456 (from geneSymbol) uc338cyr.1 uc338cyr.1 
ENSMUST00000365340.1 ENSMUSG00000141457 ENSMUST00000365340.1 ENSMUSG00000141457 (from geneSymbol) uc338cys.1 uc338cys.1 
ENSMUST00000365343.1 ENSMUSG00000141458 ENSMUST00000365343.1 ENSMUSG00000141458 (from geneSymbol) uc338cyv.1 uc338cyv.1 
ENSMUST00000365344.1 ENSMUSG00000141459 ENSMUST00000365344.1 ENSMUSG00000141459 (from geneSymbol) AB349319 uc338cyw.1 uc338cyw.1 
ENSMUST00000365347.1 ENSMUSG00000141460 ENSMUST00000365347.1 ENSMUSG00000141460 (from geneSymbol) uc338cyz.1 uc338cyz.1 
ENSMUST00000365358.1 ENSMUSG00000141461 ENSMUST00000365358.1 ENSMUSG00000141461 (from geneSymbol) uc338czk.1 uc338czk.1 
ENSMUST00000365361.1 ENSMUSG00000141462 ENSMUST00000365361.1 ENSMUSG00000141462 (from geneSymbol) uc338czn.1 uc338czn.1 
ENSMUST00000365366.1 ENSMUSG00000141463 ENSMUST00000365366.1 ENSMUSG00000141463 (from geneSymbol) uc338czs.1 uc338czs.1 
ENSMUST00000365370.1 Kis2 ENSMUST00000365370.1 Kis2 (from geneSymbol) AK084356 uc338czw.1 uc338czw.1 
ENSMUST00000365372.1 ENSMUSG00000141464 ENSMUST00000365372.1 ENSMUSG00000141464 (from geneSymbol) uc338czy.1 uc338czy.1 
ENSMUST00000365373.1 ENSMUSG00000141465 ENSMUST00000365373.1 ENSMUSG00000141465 (from geneSymbol) uc338czz.1 uc338czz.1 
ENSMUST00000365388.1 ENSMUSG00000141466 ENSMUST00000365388.1 ENSMUSG00000141466 (from geneSymbol) uc338dao.1 uc338dao.1 
ENSMUST00000365389.1 4930509G22Rik ENSMUST00000365389.1 4930509G22Rik (from geneSymbol) AK134561 uc338dap.1 uc338dap.1 
ENSMUST00000365391.1 ENSMUSG00000141467 ENSMUST00000365391.1 ENSMUSG00000141467 (from geneSymbol) uc338dar.1 uc338dar.1 
ENSMUST00000365392.1 ENSMUSG00000141468 ENSMUST00000365392.1 ENSMUSG00000141468 (from geneSymbol) uc338das.1 uc338das.1 
ENSMUST00000365415.1 9430078K24Rik ENSMUST00000365415.1 9430078K24Rik (from geneSymbol) AK020496 uc338dbp.1 uc338dbp.1 
ENSMUST00000365432.1 ENSMUSG00000141469 ENSMUST00000365432.1 ENSMUSG00000141469 (from geneSymbol) uc338dcg.1 uc338dcg.1 
ENSMUST00000365434.1 ENSMUSG00000141470 ENSMUST00000365434.1 ENSMUSG00000141470 (from geneSymbol) uc338dci.1 uc338dci.1 
ENSMUST00000365440.1 Gm33756 ENSMUST00000365440.1 Gm33756 (from geneSymbol) uc338dco.1 uc338dco.1 
ENSMUST00000365444.1 ENSMUSG00000141471 ENSMUST00000365444.1 ENSMUSG00000141471 (from geneSymbol) uc338dcs.1 uc338dcs.1 
ENSMUST00000365447.1 Gm29371 ENSMUST00000365447.1 Gm29371 (from geneSymbol) AK077157 uc338dcv.1 uc338dcv.1 
ENSMUST00000365461.1 ENSMUSG00000141472 ENSMUST00000365461.1 ENSMUSG00000141472 (from geneSymbol) BC048764 uc338ddj.1 uc338ddj.1 
ENSMUST00000365469.1 Gm57078 ENSMUST00000365469.1 Gm57078 (from geneSymbol) AK158313 uc338ddr.1 uc338ddr.1 
ENSMUST00000365477.1 ENSMUSG00000141473 ENSMUST00000365477.1 ENSMUSG00000141473 (from geneSymbol) uc338ddz.1 uc338ddz.1 
ENSMUST00000365479.1 ENSMUSG00000141474 ENSMUST00000365479.1 ENSMUSG00000141474 (from geneSymbol) uc338deb.1 uc338deb.1 
ENSMUST00000365485.1 ENSMUSG00000141475 ENSMUST00000365485.1 ENSMUSG00000141475 (from geneSymbol) uc338deh.1 uc338deh.1 
ENSMUST00000365487.1 ENSMUSG00000141476 ENSMUST00000365487.1 ENSMUSG00000141476 (from geneSymbol) uc338dej.1 uc338dej.1 
ENSMUST00000365496.1 ENSMUSG00000141477 ENSMUST00000365496.1 ENSMUSG00000141477 (from geneSymbol) AK035380 uc338des.1 uc338des.1 
ENSMUST00000365497.1 ENSMUSG00000141478 ENSMUST00000365497.1 ENSMUSG00000141478 (from geneSymbol) uc338det.1 uc338det.1 
ENSMUST00000365498.1 ENSMUSG00000141479 ENSMUST00000365498.1 ENSMUSG00000141479 (from geneSymbol) uc338deu.1 uc338deu.1 
ENSMUST00000365500.1 ENSMUSG00000141480 ENSMUST00000365500.1 ENSMUSG00000141480 (from geneSymbol) uc338dew.1 uc338dew.1 
ENSMUST00000365501.1 Gm12111 ENSMUST00000365501.1 Gm12111 (from geneSymbol) uc338dex.1 uc338dex.1 
ENSMUST00000365508.1 ENSMUSG00000141481 ENSMUST00000365508.1 ENSMUSG00000141481 (from geneSymbol) uc338dfe.1 uc338dfe.1 
ENSMUST00000365509.1 ENSMUSG00000141482 ENSMUST00000365509.1 ENSMUSG00000141482 (from geneSymbol) uc338dff.1 uc338dff.1 
ENSMUST00000365515.1 ENSMUSG00000141483 ENSMUST00000365515.1 ENSMUSG00000141483 (from geneSymbol) uc338dfl.1 uc338dfl.1 
ENSMUST00000365516.1 ENSMUSG00000141484 ENSMUST00000365516.1 ENSMUSG00000141484 (from geneSymbol) uc338dfm.1 uc338dfm.1 
ENSMUST00000365517.1 Gm41724 ENSMUST00000365517.1 Gm41724 (from geneSymbol) AK084265 uc338dfn.1 uc338dfn.1 
ENSMUST00000365527.1 ENSMUSG00000141485 ENSMUST00000365527.1 ENSMUSG00000141485 (from geneSymbol) uc338dfx.1 uc338dfx.1 
ENSMUST00000365530.1 ENSMUSG00000141486 ENSMUST00000365530.1 ENSMUSG00000141486 (from geneSymbol) uc338dga.1 uc338dga.1 
ENSMUST00000365534.1 ENSMUSG00000121778 ENSMUST00000365534.1 ENSMUSG00000121778 (from geneSymbol) BC003449 uc338dge.1 uc338dge.1 
ENSMUST00000365552.1 ENSMUSG00000141487 ENSMUST00000365552.1 ENSMUSG00000141487 (from geneSymbol) uc338dgw.1 uc338dgw.1 
ENSMUST00000365553.1 ENSMUSG00000141488 ENSMUST00000365553.1 ENSMUSG00000141488 (from geneSymbol) uc338dgx.1 uc338dgx.1 
ENSMUST00000365556.1 Gm40478 ENSMUST00000365556.1 Gm40478 (from geneSymbol) uc338dha.1 uc338dha.1 
ENSMUST00000365560.1 ENSMUSG00000141490 ENSMUST00000365560.1 ENSMUSG00000141490 (from geneSymbol) uc338dhe.1 uc338dhe.1 
ENSMUST00000365564.1 Gm14232 ENSMUST00000365564.1 Gm14232 (from geneSymbol) uc338dhi.1 uc338dhi.1 
ENSMUST00000365568.1 Gm57199 ENSMUST00000365568.1 Gm57199 (from geneSymbol) uc338dhm.1 uc338dhm.1 
ENSMUST00000365571.1 ENSMUSG00000141491 ENSMUST00000365571.1 ENSMUSG00000141491 (from geneSymbol) uc338dhp.1 uc338dhp.1 
ENSMUST00000365573.1 ENSMUSG00000141492 ENSMUST00000365573.1 ENSMUSG00000141492 (from geneSymbol) uc338dhr.1 uc338dhr.1 
ENSMUST00000365574.1 ENSMUSG00000141493 ENSMUST00000365574.1 ENSMUSG00000141493 (from geneSymbol) uc338dhs.1 uc338dhs.1 
ENSMUST00000365575.1 ENSMUSG00000141494 ENSMUST00000365575.1 ENSMUSG00000141494 (from geneSymbol) uc338dht.1 uc338dht.1 
ENSMUST00000365577.1 Gm30270 ENSMUST00000365577.1 Gm30270 (from geneSymbol) uc338dhv.1 uc338dhv.1 
ENSMUST00000365584.1 ENSMUSG00000141495 ENSMUST00000365584.1 ENSMUSG00000141495 (from geneSymbol) uc338dic.1 uc338dic.1 
ENSMUST00000365585.1 ENSMUSG00000141496 ENSMUST00000365585.1 ENSMUSG00000141496 (from geneSymbol) uc338did.1 uc338did.1 
ENSMUST00000365586.1 ENSMUSG00000141497 ENSMUST00000365586.1 ENSMUSG00000141497 (from geneSymbol) uc338die.1 uc338die.1 
ENSMUST00000365588.1 ENSMUSG00000141498 ENSMUST00000365588.1 ENSMUSG00000141498 (from geneSymbol) uc338dig.1 uc338dig.1 
ENSMUST00000365590.1 ENSMUSG00000141499 ENSMUST00000365590.1 ENSMUSG00000141499 (from geneSymbol) uc338dii.1 uc338dii.1 
ENSMUST00000365593.1 ENSMUSG00000141500 ENSMUST00000365593.1 ENSMUSG00000141500 (from geneSymbol) AK087581 uc338dil.1 uc338dil.1 
ENSMUST00000365600.1 ENSMUSG00000141501 ENSMUST00000365600.1 ENSMUSG00000141501 (from geneSymbol) uc338dis.1 uc338dis.1 
ENSMUST00000365601.1 ENSMUSG00000141502 ENSMUST00000365601.1 ENSMUSG00000141502 (from geneSymbol) uc338dit.1 uc338dit.1 
ENSMUST00000365602.1 ENSMUSG00000141503 ENSMUST00000365602.1 ENSMUSG00000141503 (from geneSymbol) uc338diu.1 uc338diu.1 
ENSMUST00000365603.1 ENSMUSG00000141504 ENSMUST00000365603.1 ENSMUSG00000141504 (from geneSymbol) uc338div.1 uc338div.1 
ENSMUST00000365604.1 Gm9975 ENSMUST00000365604.1 Gm9975 (from geneSymbol) uc338diw.1 uc338diw.1 
ENSMUST00000365607.1 ENSMUSG00000141505 ENSMUST00000365607.1 ENSMUSG00000141505 (from geneSymbol) uc338diz.1 uc338diz.1 
ENSMUST00000365615.1 ENSMUSG00000141506 ENSMUST00000365615.1 ENSMUSG00000141506 (from geneSymbol) uc338djh.1 uc338djh.1 
ENSMUST00000365617.1 ENSMUSG00000141507 ENSMUST00000365617.1 ENSMUSG00000141507 (from geneSymbol) uc338djj.1 uc338djj.1 
ENSMUST00000365620.1 ENSMUSG00000141509 ENSMUST00000365620.1 ENSMUSG00000141509 (from geneSymbol) uc338djl.1 uc338djl.1 
ENSMUST00000365621.1 Gm57254 ENSMUST00000365621.1 Gm57254 (from geneSymbol) uc338djm.1 uc338djm.1 
ENSMUST00000365624.1 Gm46362 ENSMUST00000365624.1 Gm46362 (from geneSymbol) uc338djp.1 uc338djp.1 
ENSMUST00000365638.1 ENSMUSG00000141510 ENSMUST00000365638.1 ENSMUSG00000141510 (from geneSymbol) uc338dkd.1 uc338dkd.1 
ENSMUST00000365641.1 ENSMUSG00000141511 ENSMUST00000365641.1 ENSMUSG00000141511 (from geneSymbol) uc338dkg.1 uc338dkg.1 
ENSMUST00000365642.1 ENSMUSG00000141512 ENSMUST00000365642.1 ENSMUSG00000141512 (from geneSymbol) uc338dkh.1 uc338dkh.1 
ENSMUST00000365643.1 ENSMUSG00000141513 ENSMUST00000365643.1 ENSMUSG00000141513 (from geneSymbol) uc338dki.1 uc338dki.1 
ENSMUST00000365648.1 ENSMUSG00000141514 ENSMUST00000365648.1 ENSMUSG00000141514 (from geneSymbol) uc338dkl.1 uc338dkl.1 
ENSMUST00000365667.1 ENSMUSG00000141515 ENSMUST00000365667.1 ENSMUSG00000141515 (from geneSymbol) uc338dld.1 uc338dld.1 
ENSMUST00000365670.1 ENSMUSG00000141516 ENSMUST00000365670.1 ENSMUSG00000141516 (from geneSymbol) uc338dlg.1 uc338dlg.1 
ENSMUST00000365675.1 Gm52713 ENSMUST00000365675.1 Gm52713 (from geneSymbol) uc338dll.1 uc338dll.1 
ENSMUST00000365681.1 ENSMUSG00000141517 ENSMUST00000365681.1 ENSMUSG00000141517 (from geneSymbol) uc338dlr.1 uc338dlr.1 
ENSMUST00000365691.1 ENSMUSG00000141518 ENSMUST00000365691.1 ENSMUSG00000141518 (from geneSymbol) uc338dmb.1 uc338dmb.1 
ENSMUST00000365699.1 ENSMUSG00000141519 ENSMUST00000365699.1 ENSMUSG00000141519 (from geneSymbol) uc338dmj.1 uc338dmj.1 
ENSMUST00000365705.1 ENSMUSG00000141520 ENSMUST00000365705.1 ENSMUSG00000141520 (from geneSymbol) uc338dmp.1 uc338dmp.1 
ENSMUST00000365706.1 ENSMUSG00000141521 ENSMUST00000365706.1 ENSMUSG00000141521 (from geneSymbol) uc338dmq.1 uc338dmq.1 
ENSMUST00000365707.1 Gm56873 ENSMUST00000365707.1 Gm56873 (from geneSymbol) uc338dmr.1 uc338dmr.1 
ENSMUST00000365716.1 ENSMUSG00000141522 ENSMUST00000365716.1 ENSMUSG00000141522 (from geneSymbol) uc338dna.1 uc338dna.1 
ENSMUST00000365717.1 ENSMUSG00000141523 ENSMUST00000365717.1 ENSMUSG00000141523 (from geneSymbol) uc338dnb.1 uc338dnb.1 
ENSMUST00000365719.1 ENSMUSG00000141524 ENSMUST00000365719.1 ENSMUSG00000141524 (from geneSymbol) uc338dnd.1 uc338dnd.1 
ENSMUST00000365723.1 ENSMUSG00000141525 ENSMUST00000365723.1 ENSMUSG00000141525 (from geneSymbol) uc338dnh.1 uc338dnh.1 
ENSMUST00000365724.1 ENSMUSG00000141526 ENSMUST00000365724.1 ENSMUSG00000141526 (from geneSymbol) uc338dni.1 uc338dni.1 
ENSMUST00000365730.1 ENSMUSG00000141527 ENSMUST00000365730.1 ENSMUSG00000141527 (from geneSymbol) uc338dno.1 uc338dno.1 
ENSMUST00000365733.1 Gm31693 ENSMUST00000365733.1 Gm31693 (from geneSymbol) AK132900 uc338dnr.1 uc338dnr.1 
ENSMUST00000365736.1 ENSMUSG00000141528 ENSMUST00000365736.1 carboxylesterase 2D, pseudogene (from RefSeq NR_033726.1) NR_033726 uc338dnu.1 uc338dnu.1 
ENSMUST00000365741.1 ENSMUSG00000141529 ENSMUST00000365741.1 ENSMUSG00000141529 (from geneSymbol) uc338dnz.1 uc338dnz.1 
ENSMUST00000365744.1 ENSMUSG00000141530 ENSMUST00000365744.1 ENSMUSG00000141530 (from geneSymbol) uc338doc.1 uc338doc.1 
ENSMUST00000365748.1 ENSMUSG00000141531 ENSMUST00000365748.1 ENSMUSG00000141531 (from geneSymbol) uc338dog.1 uc338dog.1 
ENSMUST00000365749.1 ENSMUSG00000141532 ENSMUST00000365749.1 ENSMUSG00000141532 (from geneSymbol) uc338doh.1 uc338doh.1 
ENSMUST00000365750.1 ENSMUSG00000141533 ENSMUST00000365750.1 ENSMUSG00000141533 (from geneSymbol) uc338doi.1 uc338doi.1 
ENSMUST00000365752.1 ENSMUSG00000141534 ENSMUST00000365752.1 ENSMUSG00000141534 (from geneSymbol) uc338dok.1 uc338dok.1 
ENSMUST00000365754.1 Gm57193 ENSMUST00000365754.1 Gm57193 (from geneSymbol) uc338dom.1 uc338dom.1 
ENSMUST00000365764.1 4933435F18Rik ENSMUST00000365764.1 4933435F18Rik (from geneSymbol) AK006220 uc338dow.1 uc338dow.1 
ENSMUST00000365773.1 ENSMUSG00000141535 ENSMUST00000365773.1 ENSMUSG00000141535 (from geneSymbol) uc338dpf.1 uc338dpf.1 
ENSMUST00000365774.1 ENSMUSG00000141536 ENSMUST00000365774.1 ENSMUSG00000141536 (from geneSymbol) uc338dpg.1 uc338dpg.1 
ENSMUST00000365775.1 ENSMUSG00000141537 ENSMUST00000365775.1 ENSMUSG00000141537 (from geneSymbol) uc338dph.1 uc338dph.1 
ENSMUST00000365776.1 ENSMUSG00000141538 ENSMUST00000365776.1 ENSMUSG00000141538 (from geneSymbol) uc338dpi.1 uc338dpi.1 
ENSMUST00000365779.1 ENSMUSG00000141539 ENSMUST00000365779.1 ENSMUSG00000141539 (from geneSymbol) uc338dpl.1 uc338dpl.1 
ENSMUST00000365780.1 ENSMUSG00000141540 ENSMUST00000365780.1 ENSMUSG00000141540 (from geneSymbol) uc338dpm.1 uc338dpm.1 
ENSMUST00000365781.1 ENSMUSG00000141541 ENSMUST00000365781.1 ENSMUSG00000141541 (from geneSymbol) uc338dpn.1 uc338dpn.1 
ENSMUST00000365784.1 Gm38577 ENSMUST00000365784.1 Gm38577 (from geneSymbol) uc338dpq.1 uc338dpq.1 
ENSMUST00000365788.1 ENSMUSG00000141542 ENSMUST00000365788.1 ENSMUSG00000141542 (from geneSymbol) uc338dpu.1 uc338dpu.1 
ENSMUST00000365789.1 ENSMUSG00000141543 ENSMUST00000365789.1 ENSMUSG00000141543 (from geneSymbol) uc338dpv.1 uc338dpv.1 
ENSMUST00000365794.1 ENSMUSG00000141544 ENSMUST00000365794.1 ENSMUSG00000141544 (from geneSymbol) uc338dqa.1 uc338dqa.1 
ENSMUST00000365795.1 ENSMUSG00000141545 ENSMUST00000365795.1 ENSMUSG00000141545 (from geneSymbol) uc338dqb.1 uc338dqb.1 
ENSMUST00000365797.1 Gm20387 ENSMUST00000365797.1 Gm20387 (from geneSymbol) AK134874 uc338dqc.1 uc338dqc.1 
ENSMUST00000365802.1 ENSMUSG00000141547 ENSMUST00000365802.1 ENSMUSG00000141547 (from geneSymbol) uc338dqh.1 uc338dqh.1 
ENSMUST00000365804.1 ENSMUSG00000141548 ENSMUST00000365804.1 ENSMUSG00000141548 (from geneSymbol) uc338dqj.1 uc338dqj.1 
ENSMUST00000365814.1 ENSMUSG00000141549 ENSMUST00000365814.1 ENSMUSG00000141549 (from geneSymbol) uc338dqt.1 uc338dqt.1 
ENSMUST00000365817.1 Gm35154 ENSMUST00000365817.1 Gm35154 (from geneSymbol) uc338dqw.1 uc338dqw.1 
ENSMUST00000365833.1 ENSMUSG00000141550 ENSMUST00000365833.1 ENSMUSG00000141550 (from geneSymbol) uc338drm.1 uc338drm.1 
ENSMUST00000365834.1 ENSMUSG00000141551 ENSMUST00000365834.1 ENSMUSG00000141551 (from geneSymbol) uc338drn.1 uc338drn.1 
ENSMUST00000365836.1 ENSMUSG00000141552 ENSMUST00000365836.1 ENSMUSG00000141552 (from geneSymbol) uc338drp.1 uc338drp.1 
ENSMUST00000365839.1 ENSMUSG00000141553 ENSMUST00000365839.1 ENSMUSG00000141553 (from geneSymbol) uc338drs.1 uc338drs.1 
ENSMUST00000365840.1 ENSMUSG00000141554 ENSMUST00000365840.1 ENSMUSG00000141554 (from geneSymbol) uc338drt.1 uc338drt.1 
ENSMUST00000365841.1 ENSMUSG00000141555 ENSMUST00000365841.1 ENSMUSG00000141555 (from geneSymbol) uc338dru.1 uc338dru.1 
ENSMUST00000365843.1 ENSMUSG00000141556 ENSMUST00000365843.1 ENSMUSG00000141556 (from geneSymbol) uc338drw.1 uc338drw.1 
ENSMUST00000365844.1 ENSMUSG00000141557 ENSMUST00000365844.1 ENSMUSG00000141557 (from geneSymbol) uc338drx.1 uc338drx.1 
ENSMUST00000365847.1 ENSMUSG00000141558 ENSMUST00000365847.1 ENSMUSG00000141558 (from geneSymbol) uc338dsa.1 uc338dsa.1 
ENSMUST00000365848.1 ENSMUSG00000141559 ENSMUST00000365848.1 ENSMUSG00000141559 (from geneSymbol) uc338dsb.1 uc338dsb.1 
ENSMUST00000365849.1 ENSMUSG00000141560 ENSMUST00000365849.1 ENSMUSG00000141560 (from geneSymbol) uc338dsc.1 uc338dsc.1 
ENSMUST00000365850.1 ENSMUSG00000141561 ENSMUST00000365850.1 ENSMUSG00000141561 (from geneSymbol) uc338dsd.1 uc338dsd.1 
ENSMUST00000365851.1 ENSMUSG00000141562 ENSMUST00000365851.1 ENSMUSG00000141562 (from geneSymbol) uc338dse.1 uc338dse.1 
ENSMUST00000365852.1 ENSMUSG00000141563 ENSMUST00000365852.1 ENSMUSG00000141563 (from geneSymbol) uc338dsf.1 uc338dsf.1 
ENSMUST00000365853.1 ENSMUSG00000141564 ENSMUST00000365853.1 ENSMUSG00000141564 (from geneSymbol) uc338dsg.1 uc338dsg.1 
ENSMUST00000365854.1 ENSMUSG00000141565 ENSMUST00000365854.1 ENSMUSG00000141565 (from geneSymbol) uc338dsh.1 uc338dsh.1 
ENSMUST00000365856.1 ENSMUSG00000141566 ENSMUST00000365856.1 ENSMUSG00000141566 (from geneSymbol) uc338dsj.1 uc338dsj.1 
ENSMUST00000365863.1 ENSMUSG00000141567 ENSMUST00000365863.1 ENSMUSG00000141567 (from geneSymbol) uc338dsq.1 uc338dsq.1 
ENSMUST00000365865.1 ENSMUSG00000141568 ENSMUST00000365865.1 ENSMUSG00000141568 (from geneSymbol) uc338dss.1 uc338dss.1 
ENSMUST00000365867.1 ENSMUSG00000141569 ENSMUST00000365867.1 ENSMUSG00000141569 (from geneSymbol) uc338dsu.1 uc338dsu.1 
ENSMUST00000365877.1 ENSMUSG00000141570 ENSMUST00000365877.1 ENSMUSG00000141570 (from geneSymbol) uc338dte.1 uc338dte.1 
ENSMUST00000365878.1 ENSMUSG00000141571 ENSMUST00000365878.1 ENSMUSG00000141571 (from geneSymbol) uc338dtf.1 uc338dtf.1 
ENSMUST00000365880.1 ENSMUSG00000141572 ENSMUST00000365880.1 ENSMUSG00000141572 (from geneSymbol) uc338dth.1 uc338dth.1 
ENSMUST00000365888.1 ENSMUSG00000141573 ENSMUST00000365888.1 ENSMUSG00000141573 (from geneSymbol) uc338dto.1 uc338dto.1 
ENSMUST00000365889.1 ENSMUSG00000141574 ENSMUST00000365889.1 ENSMUSG00000141574 (from geneSymbol) uc338dtp.1 uc338dtp.1 
ENSMUST00000365894.1 ENSMUSG00000141575 ENSMUST00000365894.1 predicted gene, 30769 (from RefSeq NR_166107.1) NR_166107 uc338dtu.1 uc338dtu.1 
ENSMUST00000365895.1 ENSMUSG00000141576 ENSMUST00000365895.1 ENSMUSG00000141576 (from geneSymbol) uc338dtv.1 uc338dtv.1 
ENSMUST00000365897.1 ENSMUSG00000141577 ENSMUST00000365897.1 ENSMUSG00000141577 (from geneSymbol) uc338dtx.1 uc338dtx.1 
ENSMUST00000365908.1 ENSMUSG00000141578 ENSMUST00000365908.1 ENSMUSG00000141578 (from geneSymbol) uc338dui.1 uc338dui.1 
ENSMUST00000365909.1 ENSMUSG00000141579 ENSMUST00000365909.1 ENSMUSG00000141579 (from geneSymbol) uc338duj.1 uc338duj.1 
ENSMUST00000365910.1 ENSMUSG00000141580 ENSMUST00000365910.1 ENSMUSG00000141580 (from geneSymbol) uc338duk.1 uc338duk.1 
ENSMUST00000365911.1 ENSMUSG00000141581 ENSMUST00000365911.1 ENSMUSG00000141581 (from geneSymbol) U01919 uc338dul.1 uc338dul.1 
ENSMUST00000365914.1 ENSMUSG00000141582 ENSMUST00000365914.1 ENSMUSG00000141582 (from geneSymbol) uc338duo.1 uc338duo.1 
ENSMUST00000365915.1 ENSMUSG00000141583 ENSMUST00000365915.1 ENSMUSG00000141583 (from geneSymbol) uc338dup.1 uc338dup.1 
ENSMUST00000365917.1 Gm30818 ENSMUST00000365917.1 Gm30818 (from geneSymbol) uc338dur.1 uc338dur.1 
ENSMUST00000365942.1 ENSMUSG00000141585 ENSMUST00000365942.1 ENSMUSG00000141585 (from geneSymbol) uc338dvq.1 uc338dvq.1 
ENSMUST00000365946.1 ENSMUSG00000141586 ENSMUST00000365946.1 ENSMUSG00000141586 (from geneSymbol) uc338dvu.1 uc338dvu.1 
ENSMUST00000365947.1 ENSMUSG00000141587 ENSMUST00000365947.1 ENSMUSG00000141587 (from geneSymbol) uc338dvv.1 uc338dvv.1 
ENSMUST00000365949.1 ENSMUSG00000141588 ENSMUST00000365949.1 ENSMUSG00000141588 (from geneSymbol) uc338dvx.1 uc338dvx.1 
ENSMUST00000365950.1 ENSMUSG00000141589 ENSMUST00000365950.1 ENSMUSG00000141589 (from geneSymbol) uc338dvy.1 uc338dvy.1 
ENSMUST00000365951.1 4930517M08Rik ENSMUST00000365951.1 4930517M08Rik (from geneSymbol) AK015816 uc338dvz.1 uc338dvz.1 
ENSMUST00000365956.1 ENSMUSG00000141590 ENSMUST00000365956.1 ENSMUSG00000141590 (from geneSymbol) uc338dwe.1 uc338dwe.1 
ENSMUST00000365957.1 ENSMUSG00000141591 ENSMUST00000365957.1 ENSMUSG00000141591 (from geneSymbol) uc338dwf.1 uc338dwf.1 
ENSMUST00000365959.1 ENSMUSG00000141592 ENSMUST00000365959.1 ENSMUSG00000141592 (from geneSymbol) uc338dwh.1 uc338dwh.1 
ENSMUST00000365971.1 ENSMUSG00000141593 ENSMUST00000365971.1 ENSMUSG00000141593 (from geneSymbol) uc338dwt.1 uc338dwt.1 
ENSMUST00000365972.1 Gm44731 ENSMUST00000365972.1 Gm44731 (from geneSymbol) uc338dwu.1 uc338dwu.1 
ENSMUST00000365973.1 ENSMUSG00000141594 ENSMUST00000365973.1 ENSMUSG00000141594 (from geneSymbol) uc338dwv.1 uc338dwv.1 
ENSMUST00000365975.1 4930548G14Rik ENSMUST00000365975.1 4930548G14Rik (from geneSymbol) AK016069 uc338dwx.1 uc338dwx.1 
ENSMUST00000365991.1 ENSMUSG00000141595 ENSMUST00000365991.1 ENSMUSG00000141595 (from geneSymbol) uc338dxn.1 uc338dxn.1 
ENSMUST00000365992.1 ENSMUSG00000141596 ENSMUST00000365992.1 ENSMUSG00000141596 (from geneSymbol) uc338dxo.1 uc338dxo.1 
ENSMUST00000365993.1 ENSMUSG00000141597 ENSMUST00000365993.1 ENSMUSG00000141597 (from geneSymbol) uc338dxp.1 uc338dxp.1 
ENSMUST00000365994.1 ENSMUSG00000141598 ENSMUST00000365994.1 ENSMUSG00000141598 (from geneSymbol) uc338dxq.1 uc338dxq.1 
ENSMUST00000365998.1 ENSMUSG00000141599 ENSMUST00000365998.1 ENSMUSG00000141599 (from geneSymbol) uc338dxu.1 uc338dxu.1 
ENSMUST00000365999.1 ENSMUSG00000141600 ENSMUST00000365999.1 ENSMUSG00000141600 (from geneSymbol) AK138182 uc338dxv.1 uc338dxv.1 
ENSMUST00000366029.1 ENSMUSG00000141601 ENSMUST00000366029.1 ENSMUSG00000141601 (from geneSymbol) uc338dyz.1 uc338dyz.1 
ENSMUST00000366030.1 ENSMUSG00000141602 ENSMUST00000366030.1 ENSMUSG00000141602 (from geneSymbol) uc338dza.1 uc338dza.1 
ENSMUST00000366033.1 ENSMUSG00000141603 ENSMUST00000366033.1 ENSMUSG00000141603 (from geneSymbol) uc338dzd.1 uc338dzd.1 
ENSMUST00000366034.1 ENSMUSG00000141604 ENSMUST00000366034.1 ENSMUSG00000141604 (from geneSymbol) uc338dze.1 uc338dze.1 
ENSMUST00000366035.1 ENSMUSG00000141605 ENSMUST00000366035.1 ENSMUSG00000141605 (from geneSymbol) uc338dzf.1 uc338dzf.1 
ENSMUST00000366036.1 ENSMUSG00000141606 ENSMUST00000366036.1 ENSMUSG00000141606 (from geneSymbol) uc338dzg.1 uc338dzg.1 
ENSMUST00000366045.1 ENSMUSG00000141607 ENSMUST00000366045.1 ENSMUSG00000141607 (from geneSymbol) uc338dzp.1 uc338dzp.1 
ENSMUST00000366056.1 4930448C13Rik ENSMUST00000366056.1 4930448C13Rik (from geneSymbol) AK015413 uc338eaa.1 uc338eaa.1 
ENSMUST00000366125.1 ENSMUSG00000141608 ENSMUST00000366125.1 ENSMUSG00000141608 (from geneSymbol) uc338ecr.1 uc338ecr.1 
ENSMUST00000366134.1 ENSMUSG00000141609 ENSMUST00000366134.1 ENSMUSG00000141609 (from geneSymbol) uc338ecz.1 uc338ecz.1 
ENSMUST00000366136.1 ENSMUSG00000141610 ENSMUST00000366136.1 ENSMUSG00000141610 (from geneSymbol) uc338edb.1 uc338edb.1 
ENSMUST00000366137.1 Gm57337 ENSMUST00000366137.1 Gm57337 (from geneSymbol) uc338edc.1 uc338edc.1 
ENSMUST00000366141.1 ENSMUSG00000141611 ENSMUST00000366141.1 ENSMUSG00000141611 (from geneSymbol) uc338edg.1 uc338edg.1 
ENSMUST00000366143.1 ENSMUSG00000141612 ENSMUST00000366143.1 ENSMUSG00000141612 (from geneSymbol) uc338edi.1 uc338edi.1 
ENSMUST00000366145.1 ENSMUSG00000141613 ENSMUST00000366145.1 ENSMUSG00000141613 (from geneSymbol) uc338edk.1 uc338edk.1 
ENSMUST00000366147.1 ENSMUSG00000141614 ENSMUST00000366147.1 ENSMUSG00000141614 (from geneSymbol) uc338edm.1 uc338edm.1 
ENSMUST00000366148.1 ENSMUSG00000141615 ENSMUST00000366148.1 ENSMUSG00000141615 (from geneSymbol) LF199448 uc338edn.1 uc338edn.1 
ENSMUST00000366149.1 ENSMUSG00000141616 ENSMUST00000366149.1 ENSMUSG00000141616 (from geneSymbol) uc338edo.1 uc338edo.1 
ENSMUST00000366155.1 ENSMUSG00000141617 ENSMUST00000366155.1 ENSMUSG00000141617 (from geneSymbol) uc338edu.1 uc338edu.1 
ENSMUST00000366156.1 ENSMUSG00000141618 ENSMUST00000366156.1 ENSMUSG00000141618 (from geneSymbol) uc338edv.1 uc338edv.1 
ENSMUST00000366160.1 ENSMUSG00000141619 ENSMUST00000366160.1 ENSMUSG00000141619 (from geneSymbol) uc338edz.1 uc338edz.1 
ENSMUST00000366161.1 ENSMUSG00000141620 ENSMUST00000366161.1 ENSMUSG00000141620 (from geneSymbol) uc338eea.1 uc338eea.1 
ENSMUST00000366165.1 Gm26728 ENSMUST00000366165.1 Gm26728 (from geneSymbol) AK163717 uc338eee.1 uc338eee.1 
ENSMUST00000366183.1 ENSMUSG00000141621 ENSMUST00000366183.1 ENSMUSG00000141621 (from geneSymbol) uc338eew.1 uc338eew.1 
ENSMUST00000366184.1 ENSMUSG00000141622 ENSMUST00000366184.1 ENSMUSG00000141622 (from geneSymbol) uc338eex.1 uc338eex.1 
ENSMUST00000366185.1 ENSMUSG00000141623 ENSMUST00000366185.1 ENSMUSG00000141623 (from geneSymbol) uc338eey.1 uc338eey.1 
ENSMUST00000366186.1 ENSMUSG00000141624 ENSMUST00000366186.1 ENSMUSG00000141624 (from geneSymbol) uc338eez.1 uc338eez.1 
ENSMUST00000366190.1 ENSMUSG00000141625 ENSMUST00000366190.1 ENSMUSG00000141625 (from geneSymbol) uc338efd.1 uc338efd.1 
ENSMUST00000366191.1 ENSMUSG00000141626 ENSMUST00000366191.1 ENSMUSG00000141626 (from geneSymbol) uc338efe.1 uc338efe.1 
ENSMUST00000366192.1 ENSMUSG00000141627 ENSMUST00000366192.1 ENSMUSG00000141627 (from geneSymbol) uc338eff.1 uc338eff.1 
ENSMUST00000366195.1 C330013E15Rik ENSMUST00000366195.1 C330013E15Rik (from geneSymbol) AK083680 uc338efh.1 uc338efh.1 
ENSMUST00000366220.1 ENSMUSG00000141629 ENSMUST00000366220.1 ENSMUSG00000141629 (from geneSymbol) uc338egg.1 uc338egg.1 
ENSMUST00000366224.1 ENSMUSG00000141630 ENSMUST00000366224.1 ENSMUSG00000141630 (from geneSymbol) uc338egk.1 uc338egk.1 
ENSMUST00000366225.1 Gm48065 ENSMUST00000366225.1 Gm48065 (from geneSymbol) uc338egl.1 uc338egl.1 
ENSMUST00000366236.1 ENSMUSG00000141631 ENSMUST00000366236.1 ENSMUSG00000141631 (from geneSymbol) uc338egw.1 uc338egw.1 
ENSMUST00000366238.1 ENSMUSG00000141632 ENSMUST00000366238.1 ENSMUSG00000141632 (from geneSymbol) uc338egy.1 uc338egy.1 
ENSMUST00000366247.1 ENSMUSG00000141633 ENSMUST00000366247.1 ENSMUSG00000141633 (from geneSymbol) uc338ehh.1 uc338ehh.1 
ENSMUST00000366251.1 ENSMUSG00000141634 ENSMUST00000366251.1 ENSMUSG00000141634 (from geneSymbol) uc338ehl.1 uc338ehl.1 
ENSMUST00000366252.1 ENSMUSG00000141635 ENSMUST00000366252.1 ENSMUSG00000141635 (from geneSymbol) uc338ehm.1 uc338ehm.1 
ENSMUST00000366253.1 ENSMUSG00000141636 ENSMUST00000366253.1 ENSMUSG00000141636 (from geneSymbol) uc338ehn.1 uc338ehn.1 
ENSMUST00000366254.1 ENSMUSG00000141637 ENSMUST00000366254.1 ENSMUSG00000141637 (from geneSymbol) uc338eho.1 uc338eho.1 
ENSMUST00000366255.1 ENSMUSG00000141638 ENSMUST00000366255.1 ENSMUSG00000141638 (from geneSymbol) uc338ehp.1 uc338ehp.1 
ENSMUST00000366256.1 ENSMUSG00000141639 ENSMUST00000366256.1 ENSMUSG00000141639 (from geneSymbol) uc338ehq.1 uc338ehq.1 
ENSMUST00000366257.1 Gm34721 ENSMUST00000366257.1 Gm34721 (from geneSymbol) uc338ehr.1 uc338ehr.1 
ENSMUST00000366259.1 ENSMUSG00000141640 ENSMUST00000366259.1 ENSMUSG00000141640 (from geneSymbol) uc338eht.1 uc338eht.1 
ENSMUST00000366263.1 ENSMUSG00000141641 ENSMUST00000366263.1 ENSMUSG00000141641 (from geneSymbol) uc338ehx.1 uc338ehx.1 
ENSMUST00000366264.1 ENSMUSG00000141642 ENSMUST00000366264.1 ENSMUSG00000141642 (from geneSymbol) uc338ehy.1 uc338ehy.1 
ENSMUST00000366265.1 ENSMUSG00000141643 ENSMUST00000366265.1 ENSMUSG00000141643 (from geneSymbol) uc338ehz.1 uc338ehz.1 
ENSMUST00000366266.1 ENSMUSG00000121817 ENSMUST00000366266.1 ENSMUSG00000121817 (from geneSymbol) uc338eia.1 uc338eia.1 
ENSMUST00000366270.1 ENSMUSG00000141644 ENSMUST00000366270.1 ENSMUSG00000141644 (from geneSymbol) uc338eid.1 uc338eid.1 
ENSMUST00000366272.1 ENSMUSG00000141645 ENSMUST00000366272.1 ENSMUSG00000141645 (from geneSymbol) uc338eif.1 uc338eif.1 
ENSMUST00000366274.1 ENSMUSG00000141646 ENSMUST00000366274.1 ENSMUSG00000141646 (from geneSymbol) uc338eih.1 uc338eih.1 
ENSMUST00000366275.1 ENSMUSG00000141647 ENSMUST00000366275.1 ENSMUSG00000141647 (from geneSymbol) uc338eii.1 uc338eii.1 
ENSMUST00000366276.1 ENSMUSG00000141648 ENSMUST00000366276.1 ENSMUSG00000141648 (from geneSymbol) uc338eij.1 uc338eij.1 
ENSMUST00000366281.1 ENSMUSG00000141649 ENSMUST00000366281.1 ENSMUSG00000141649 (from geneSymbol) uc338eio.1 uc338eio.1 
ENSMUST00000366300.1 ENSMUSG00000141650 ENSMUST00000366300.1 ENSMUSG00000141650 (from geneSymbol) uc338ejh.1 uc338ejh.1 
ENSMUST00000366302.1 ENSMUSG00000141651 ENSMUST00000366302.1 ENSMUSG00000141651 (from geneSymbol) uc338ejj.1 uc338ejj.1 
ENSMUST00000366303.1 ENSMUSG00000141652 ENSMUST00000366303.1 ENSMUSG00000141652 (from geneSymbol) uc338ejk.1 uc338ejk.1 
ENSMUST00000366304.1 6030471H07Rik ENSMUST00000366304.1 6030471H07Rik (from geneSymbol) AK020082 uc338ejl.1 uc338ejl.1 
ENSMUST00000366305.1 ENSMUSG00000141653 ENSMUST00000366305.1 ENSMUSG00000141653 (from geneSymbol) uc338ejm.1 uc338ejm.1 
ENSMUST00000366307.1 ENSMUSG00000141654 ENSMUST00000366307.1 ENSMUSG00000141654 (from geneSymbol) uc338ejo.1 uc338ejo.1 
ENSMUST00000366318.1 ENSMUSG00000141655 ENSMUST00000366318.1 ENSMUSG00000141655 (from geneSymbol) uc338ejz.1 uc338ejz.1 
ENSMUST00000366323.1 ENSMUSG00000141656 ENSMUST00000366323.1 ENSMUSG00000141656 (from geneSymbol) uc338eke.1 uc338eke.1 
ENSMUST00000366324.1 Gm33447 ENSMUST00000366324.1 Gm33447 (from geneSymbol) AK050283 uc338ekf.1 uc338ekf.1 
ENSMUST00000366326.1 1700021A07Rik ENSMUST00000366326.1 1700021A07Rik (from geneSymbol) AK006189 uc338ekh.1 uc338ekh.1 
ENSMUST00000366330.1 ENSMUSG00000141657 ENSMUST00000366330.1 ENSMUSG00000141657 (from geneSymbol) uc338ekl.1 uc338ekl.1 
ENSMUST00000366331.1 ENSMUSG00000141658 ENSMUST00000366331.1 ENSMUSG00000141658 (from geneSymbol) uc338ekm.1 uc338ekm.1 
ENSMUST00000366334.1 ENSMUSG00000141659 ENSMUST00000366334.1 ENSMUSG00000141659 (from geneSymbol) uc338ekp.1 uc338ekp.1 
ENSMUST00000366335.1 ENSMUSG00000141660 ENSMUST00000366335.1 ENSMUSG00000141660 (from geneSymbol) uc338ekq.1 uc338ekq.1 
ENSMUST00000366336.1 ENSMUSG00000141661 ENSMUST00000366336.1 ENSMUSG00000141661 (from geneSymbol) uc338ekr.1 uc338ekr.1 
ENSMUST00000366339.1 Gm36793 ENSMUST00000366339.1 Gm36793 (from geneSymbol) AK076906 uc338eku.1 uc338eku.1 
ENSMUST00000366343.1 ENSMUSG00000141662 ENSMUST00000366343.1 ENSMUSG00000141662 (from geneSymbol) uc338eky.1 uc338eky.1 
ENSMUST00000366344.1 ENSMUSG00000141663 ENSMUST00000366344.1 ENSMUSG00000141663 (from geneSymbol) uc338ekz.1 uc338ekz.1 
ENSMUST00000366345.1 ENSMUSG00000141664 ENSMUST00000366345.1 ENSMUSG00000141664 (from geneSymbol) uc338ela.1 uc338ela.1 
ENSMUST00000366349.1 4930448F12Rik ENSMUST00000366349.1 4930448F12Rik (from geneSymbol) AK015417 uc338elc.1 uc338elc.1 
ENSMUST00000366351.1 ENSMUSG00000141666 ENSMUST00000366351.1 ENSMUSG00000141666 (from geneSymbol) uc338ele.1 uc338ele.1 
ENSMUST00000366360.1 ENSMUSG00000141667 ENSMUST00000366360.1 ENSMUSG00000141667 (from geneSymbol) uc338eln.1 uc338eln.1 
ENSMUST00000366361.1 ENSMUSG00000141668 ENSMUST00000366361.1 ENSMUSG00000141668 (from geneSymbol) uc338elo.1 uc338elo.1 
ENSMUST00000366365.1 ENSMUSG00000141669 ENSMUST00000366365.1 ENSMUSG00000141669 (from geneSymbol) uc338els.1 uc338els.1 
ENSMUST00000366366.1 ENSMUSG00000141670 ENSMUST00000366366.1 ENSMUSG00000141670 (from geneSymbol) uc338elt.1 uc338elt.1 
ENSMUST00000366377.1 ENSMUSG00000141671 ENSMUST00000366377.1 ENSMUSG00000141671 (from geneSymbol) uc338eme.1 uc338eme.1 
ENSMUST00000366378.1 Gm36129 ENSMUST00000366378.1 Gm36129 (from geneSymbol) uc338emf.1 uc338emf.1 
ENSMUST00000366390.1 ENSMUSG00000141672 ENSMUST00000366390.1 ENSMUSG00000141672 (from geneSymbol) uc338emr.1 uc338emr.1 
ENSMUST00000366391.1 ENSMUSG00000141673 ENSMUST00000366391.1 ENSMUSG00000141673 (from geneSymbol) uc338ems.1 uc338ems.1 
ENSMUST00000366393.1 ENSMUSG00000141674 ENSMUST00000366393.1 ENSMUSG00000141674 (from geneSymbol) uc338emu.1 uc338emu.1 
ENSMUST00000366394.1 Gm49127 ENSMUST00000366394.1 Gm49127 (from geneSymbol) uc338emv.1 uc338emv.1 
ENSMUST00000366397.1 ENSMUSG00000141675 ENSMUST00000366397.1 ENSMUSG00000141675 (from geneSymbol) uc338emy.1 uc338emy.1 
ENSMUST00000366398.1 ENSMUSG00000141676 ENSMUST00000366398.1 ENSMUSG00000141676 (from geneSymbol) uc338emz.1 uc338emz.1 
ENSMUST00000366401.1 ENSMUSG00000141677 ENSMUST00000366401.1 ENSMUSG00000141677 (from geneSymbol) LF204937 uc338enc.1 uc338enc.1 
ENSMUST00000366402.1 ENSMUSG00000141678 ENSMUST00000366402.1 ENSMUSG00000141678 (from geneSymbol) uc338end.1 uc338end.1 
ENSMUST00000366403.1 ENSMUSG00000141679 ENSMUST00000366403.1 ENSMUSG00000141679 (from geneSymbol) uc338ene.1 uc338ene.1 
ENSMUST00000366404.1 ENSMUSG00000141680 ENSMUST00000366404.1 ENSMUSG00000141680 (from geneSymbol) EF410147 uc338enf.1 uc338enf.1 
ENSMUST00000366424.1 ENSMUSG00000141681 ENSMUST00000366424.1 ENSMUSG00000141681 (from geneSymbol) uc338enz.1 uc338enz.1 
ENSMUST00000366425.1 ENSMUSG00000141682 ENSMUST00000366425.1 ENSMUSG00000141682 (from geneSymbol) uc338eoa.1 uc338eoa.1 
ENSMUST00000366426.1 ENSMUSG00000141683 ENSMUST00000366426.1 ENSMUSG00000141683 (from geneSymbol) uc338eob.1 uc338eob.1 
ENSMUST00000366428.1 1700021J08Rik ENSMUST00000366428.1 1700021J08Rik (from geneSymbol) AK006209 uc338eod.1 uc338eod.1 
ENSMUST00000366430.1 ENSMUSG00000141684 ENSMUST00000366430.1 ENSMUSG00000141684 (from geneSymbol) uc338eof.1 uc338eof.1 
ENSMUST00000366433.1 ENSMUSG00000141685 ENSMUST00000366433.1 ENSMUSG00000141685 (from geneSymbol) uc338eoi.1 uc338eoi.1 
ENSMUST00000366434.1 ENSMUSG00000141686 ENSMUST00000366434.1 ENSMUSG00000141686 (from geneSymbol) uc338eoj.1 uc338eoj.1 
ENSMUST00000366435.1 ENSMUSG00000141687 ENSMUST00000366435.1 ENSMUSG00000141687 (from geneSymbol) uc338eok.1 uc338eok.1 
ENSMUST00000366436.1 ENSMUSG00000141688 ENSMUST00000366436.1 ENSMUSG00000141688 (from geneSymbol) uc338eol.1 uc338eol.1 
ENSMUST00000366439.1 4930437M23Rik ENSMUST00000366439.1 4930437M23Rik (from geneSymbol) AK015330 uc338eoo.1 uc338eoo.1 
ENSMUST00000366457.1 ENSMUSG00000141689 ENSMUST00000366457.1 ENSMUSG00000141689 (from geneSymbol) uc338epg.1 uc338epg.1 
ENSMUST00000366459.1 ENSMUSG00000141690 ENSMUST00000366459.1 ENSMUSG00000141690 (from geneSymbol) uc338epi.1 uc338epi.1 
ENSMUST00000366460.1 ENSMUSG00000141691 ENSMUST00000366460.1 ENSMUSG00000141691 (from geneSymbol) uc338epj.1 uc338epj.1 
ENSMUST00000366462.1 ENSMUSG00000141693 ENSMUST00000366462.1 ENSMUSG00000141693 (from geneSymbol) uc338epk.1 uc338epk.1 
ENSMUST00000366463.1 ENSMUSG00000141694 ENSMUST00000366463.1 ENSMUSG00000141694 (from geneSymbol) uc338epl.1 uc338epl.1 
ENSMUST00000366467.1 ENSMUSG00000141695 ENSMUST00000366467.1 ENSMUSG00000141695 (from geneSymbol) uc338epp.1 uc338epp.1 
ENSMUST00000366468.1 ENSMUSG00000141696 ENSMUST00000366468.1 ENSMUSG00000141696 (from geneSymbol) uc338epq.1 uc338epq.1 
ENSMUST00000366470.1 ENSMUSG00000141697 ENSMUST00000366470.1 ENSMUSG00000141697 (from geneSymbol) uc338eps.1 uc338eps.1 
ENSMUST00000366472.1 Gm57076 ENSMUST00000366472.1 Gm57076 (from geneSymbol) uc338epu.1 uc338epu.1 
ENSMUST00000366482.1 ENSMUSG00000141698 ENSMUST00000366482.1 ENSMUSG00000141698 (from geneSymbol) uc338eqe.1 uc338eqe.1 
ENSMUST00000366483.1 ENSMUSG00000141699 ENSMUST00000366483.1 ENSMUSG00000141699 (from geneSymbol) uc338eqf.1 uc338eqf.1 
ENSMUST00000366489.1 ENSMUSG00000141700 ENSMUST00000366489.1 ENSMUSG00000141700 (from geneSymbol) uc338eql.1 uc338eql.1 
ENSMUST00000366490.1 ENSMUSG00000141701 ENSMUST00000366490.1 ENSMUSG00000141701 (from geneSymbol) uc338eqm.1 uc338eqm.1 
ENSMUST00000366495.1 ENSMUSG00000141702 ENSMUST00000366495.1 ENSMUSG00000141702 (from geneSymbol) uc338eqr.1 uc338eqr.1 
ENSMUST00000366496.1 ENSMUSG00000141703 ENSMUST00000366496.1 ENSMUSG00000141703 (from geneSymbol) uc338eqs.1 uc338eqs.1 
ENSMUST00000366497.1 ENSMUSG00000141704 ENSMUST00000366497.1 ENSMUSG00000141704 (from geneSymbol) uc338eqt.1 uc338eqt.1 
ENSMUST00000366501.1 ENSMUSG00000141705 ENSMUST00000366501.1 ENSMUSG00000141705 (from geneSymbol) uc338eqx.1 uc338eqx.1 
ENSMUST00000366513.1 ENSMUSG00000141706 ENSMUST00000366513.1 ENSMUSG00000141706 (from geneSymbol) uc338erj.1 uc338erj.1 
ENSMUST00000366514.1 ENSMUSG00000141707 ENSMUST00000366514.1 ENSMUSG00000141707 (from geneSymbol) BC089466 uc338erk.1 uc338erk.1 
ENSMUST00000366515.1 ENSMUSG00000141708 ENSMUST00000366515.1 ENSMUSG00000141708 (from geneSymbol) uc338erl.1 uc338erl.1 
ENSMUST00000366517.1 8030442B05Rik ENSMUST00000366517.1 8030442B05Rik (from geneSymbol) AK020198 uc338ern.1 uc338ern.1 
ENSMUST00000366527.1 ENSMUSG00000141709 ENSMUST00000366527.1 ENSMUSG00000141709 (from geneSymbol) AK019041 uc338erx.1 uc338erx.1 
ENSMUST00000366528.1 ENSMUSG00000141710 ENSMUST00000366528.1 ENSMUSG00000141710 (from geneSymbol) uc338ery.1 uc338ery.1 
ENSMUST00000366530.1 ENSMUSG00000141711 ENSMUST00000366530.1 ENSMUSG00000141711 (from geneSymbol) uc338esa.1 uc338esa.1 
ENSMUST00000366533.1 ENSMUSG00000121392 ENSMUST00000366533.1 ENSMUSG00000121392 (from geneSymbol) uc338esd.1 uc338esd.1 
ENSMUST00000366536.1 ENSMUSG00000141712 ENSMUST00000366536.1 ENSMUSG00000141712 (from geneSymbol) uc338esg.1 uc338esg.1 
ENSMUST00000366567.1 ENSMUSG00000141713 ENSMUST00000366567.1 ENSMUSG00000141713 (from geneSymbol) uc338etl.1 uc338etl.1 
ENSMUST00000366570.1 ENSMUSG00000141715 ENSMUST00000366570.1 ENSMUSG00000141715 (from geneSymbol) uc338etn.1 uc338etn.1 
ENSMUST00000366571.1 ENSMUSG00000141716 ENSMUST00000366571.1 ENSMUSG00000141716 (from geneSymbol) uc338eto.1 uc338eto.1 
ENSMUST00000366575.1 ENSMUSG00000141717 ENSMUST00000366575.1 ENSMUSG00000141717 (from geneSymbol) uc338ets.1 uc338ets.1 
ENSMUST00000366576.1 ENSMUSG00000141718 ENSMUST00000366576.1 ENSMUSG00000141718 (from geneSymbol) uc338ett.1 uc338ett.1 
ENSMUST00000366577.1 Gm39043 ENSMUST00000366577.1 Gm39043 (from geneSymbol) uc338etu.1 uc338etu.1 
ENSMUST00000366584.1 ENSMUSG00000141719 ENSMUST00000366584.1 ENSMUSG00000141719 (from geneSymbol) uc338eub.1 uc338eub.1 
ENSMUST00000366586.1 ENSMUSG00000141720 ENSMUST00000366586.1 ENSMUSG00000141720 (from geneSymbol) uc338eud.1 uc338eud.1 
ENSMUST00000366587.1 ENSMUSG00000141721 ENSMUST00000366587.1 ENSMUSG00000141721 (from geneSymbol) uc338eue.1 uc338eue.1 
ENSMUST00000366595.1 ENSMUSG00000141722 ENSMUST00000366595.1 ENSMUSG00000141722 (from geneSymbol) uc338eum.1 uc338eum.1 
ENSMUST00000366596.1 ENSMUSG00000141723 ENSMUST00000366596.1 ENSMUSG00000141723 (from geneSymbol) uc338eun.1 uc338eun.1 
ENSMUST00000366597.1 ENSMUSG00000141724 ENSMUST00000366597.1 ENSMUSG00000141724 (from geneSymbol) uc338euo.1 uc338euo.1 
ENSMUST00000366603.1 ENSMUSG00000141725 ENSMUST00000366603.1 ENSMUSG00000141725 (from geneSymbol) uc338euu.1 uc338euu.1 
ENSMUST00000366604.1 ENSMUSG00000141726 ENSMUST00000366604.1 ENSMUSG00000141726 (from geneSymbol) uc338euv.1 uc338euv.1 
ENSMUST00000366606.1 ENSMUSG00000141727 ENSMUST00000366606.1 ENSMUSG00000141727 (from geneSymbol) uc338eux.1 uc338eux.1 
ENSMUST00000366609.1 ENSMUSG00000141728 ENSMUST00000366609.1 ENSMUSG00000141728 (from geneSymbol) uc338eva.1 uc338eva.1 
ENSMUST00000366615.1 Gm46111 ENSMUST00000366615.1 predicted gene, 46111, transcript variant 1 (from RefSeq NR_168533.1) NR_168533 uc338evg.1 uc338evg.1 
ENSMUST00000366628.1 4930440C22Rik ENSMUST00000366628.1 4930440C22Rik (from geneSymbol) AK015347 uc338evt.1 uc338evt.1 
ENSMUST00000366653.1 ENSMUSG00000141730 ENSMUST00000366653.1 ENSMUSG00000141730 (from geneSymbol) uc338ews.1 uc338ews.1 
ENSMUST00000366655.1 ENSMUSG00000141731 ENSMUST00000366655.1 ENSMUSG00000141731 (from geneSymbol) uc338ewu.1 uc338ewu.1 
ENSMUST00000366663.1 ENSMUSG00000141732 ENSMUST00000366663.1 ENSMUSG00000141732 (from geneSymbol) uc338exc.1 uc338exc.1 
ENSMUST00000366664.1 ENSMUSG00000141733 ENSMUST00000366664.1 ENSMUSG00000141733 (from geneSymbol) uc338exd.1 uc338exd.1 
ENSMUST00000366677.1 ENSMUSG00000141734 ENSMUST00000366677.1 ENSMUSG00000141734 (from geneSymbol) uc338exp.1 uc338exp.1 
ENSMUST00000366679.1 ENSMUSG00000141736 ENSMUST00000366679.1 ENSMUSG00000141736 (from geneSymbol) uc338exq.1 uc338exq.1 
ENSMUST00000366682.1 ENSMUSG00000141737 ENSMUST00000366682.1 ENSMUSG00000141737 (from geneSymbol) uc338ext.1 uc338ext.1 
ENSMUST00000366684.1 Gm15337 ENSMUST00000366684.1 Gm15337 (from geneSymbol) AK158482 uc338exv.1 uc338exv.1 
ENSMUST00000366692.1 ENSMUSG00000141738 ENSMUST00000366692.1 ENSMUSG00000141738 (from geneSymbol) uc338eyd.1 uc338eyd.1 
ENSMUST00000366702.1 ENSMUSG00000141739 ENSMUST00000366702.1 ENSMUSG00000141739 (from geneSymbol) uc338eyn.1 uc338eyn.1 
ENSMUST00000366704.1 Gm33051 ENSMUST00000366704.1 Gm33051 (from geneSymbol) uc338eyp.1 uc338eyp.1 
ENSMUST00000366707.1 ENSMUSG00000141740 ENSMUST00000366707.1 ENSMUSG00000141740 (from geneSymbol) uc338eys.1 uc338eys.1 
ENSMUST00000366711.1 Gm2619 ENSMUST00000366711.1 Gm2619 (from geneSymbol) uc338eyw.1 uc338eyw.1 
ENSMUST00000366727.1 ENSMUSG00000141741 ENSMUST00000366727.1 ENSMUSG00000141741 (from geneSymbol) uc338ezl.1 uc338ezl.1 
ENSMUST00000366728.1 ENSMUSG00000141742 ENSMUST00000366728.1 ENSMUSG00000141742 (from geneSymbol) uc338ezm.1 uc338ezm.1 
ENSMUST00000366732.1 Gm13291 ENSMUST00000366732.1 Gm13291 (from geneSymbol) AK133169 uc338ezq.1 uc338ezq.1 
ENSMUST00000366737.1 B230110G15Rik ENSMUST00000366737.1 B230110G15Rik (from geneSymbol) AK020962 uc338ezv.1 uc338ezv.1 
ENSMUST00000366743.1 ENSMUSG00000141743 ENSMUST00000366743.1 ENSMUSG00000141743 (from geneSymbol) uc338fab.1 uc338fab.1 
ENSMUST00000366746.1 ENSMUSG00000141744 ENSMUST00000366746.1 ENSMUSG00000141744 (from geneSymbol) uc338fae.1 uc338fae.1 
ENSMUST00000366749.1 ENSMUSG00000141745 ENSMUST00000366749.1 ENSMUSG00000141745 (from geneSymbol) uc338fah.1 uc338fah.1 
ENSMUST00000366755.1 Gm15635 ENSMUST00000366755.1 Gm15635 (from geneSymbol) uc338fan.1 uc338fan.1 
ENSMUST00000366756.1 ENSMUSG00000141746 ENSMUST00000366756.1 ENSMUSG00000141746 (from geneSymbol) uc338fao.1 uc338fao.1 
ENSMUST00000366757.1 ENSMUSG00000141747 ENSMUST00000366757.1 ENSMUSG00000141747 (from geneSymbol) uc338fap.1 uc338fap.1 
ENSMUST00000366760.1 ENSMUSG00000141748 ENSMUST00000366760.1 ENSMUSG00000141748 (from geneSymbol) uc338fas.1 uc338fas.1 
ENSMUST00000366767.1 ENSMUSG00000141749 ENSMUST00000366767.1 ENSMUSG00000141749 (from geneSymbol) uc338faz.1 uc338faz.1 
ENSMUST00000366774.1 ENSMUSG00000141750 ENSMUST00000366774.1 ENSMUSG00000141750 (from geneSymbol) uc338fbg.1 uc338fbg.1 
ENSMUST00000366780.1 ENSMUSG00000141751 ENSMUST00000366780.1 ENSMUSG00000141751 (from geneSymbol) uc338fbm.1 uc338fbm.1 
ENSMUST00000366784.1 ENSMUSG00000141752 ENSMUST00000366784.1 ENSMUSG00000141752 (from geneSymbol) uc338fbq.1 uc338fbq.1 
ENSMUST00000366786.1 ENSMUSG00000141753 ENSMUST00000366786.1 ENSMUSG00000141753 (from geneSymbol) uc338fbs.1 uc338fbs.1 
ENSMUST00000366789.1 ENSMUSG00000141754 ENSMUST00000366789.1 ENSMUSG00000141754 (from geneSymbol) uc338fbv.1 uc338fbv.1 
ENSMUST00000366791.1 ENSMUSG00000141755 ENSMUST00000366791.1 ENSMUSG00000141755 (from geneSymbol) uc338fbx.1 uc338fbx.1 
ENSMUST00000366792.1 C530044C16Rik ENSMUST00000366792.1 C530044C16Rik (from geneSymbol) AK043004 uc338fby.1 uc338fby.1 
ENSMUST00000366820.1 ENSMUSG00000141756 ENSMUST00000366820.1 ENSMUSG00000141756 (from geneSymbol) uc338fda.1 uc338fda.1 
ENSMUST00000366821.1 ENSMUSG00000141757 ENSMUST00000366821.1 ENSMUSG00000141757 (from geneSymbol) uc338fdb.1 uc338fdb.1 
ENSMUST00000366828.1 ENSMUSG00000141758 ENSMUST00000366828.1 ENSMUSG00000141758 (from geneSymbol) uc338fdi.1 uc338fdi.1 
ENSMUST00000366836.1 C330002G04Rik ENSMUST00000366836.1 C330002G04Rik (from geneSymbol) BC044868 uc338fdq.1 uc338fdq.1 
ENSMUST00000366869.1 ENSMUSG00000141759 ENSMUST00000366869.1 ENSMUSG00000141759 (from geneSymbol) uc338fex.1 uc338fex.1 
ENSMUST00000366870.1 ENSMUSG00000141760 ENSMUST00000366870.1 ENSMUSG00000141760 (from geneSymbol) uc338fey.1 uc338fey.1 
ENSMUST00000366892.1 ENSMUSG00000141761 ENSMUST00000366892.1 ENSMUSG00000141761 (from geneSymbol) uc338ffu.1 uc338ffu.1 
ENSMUST00000366902.1 ENSMUSG00000141762 ENSMUST00000366902.1 ENSMUSG00000141762 (from geneSymbol) uc338fge.1 uc338fge.1 
ENSMUST00000366907.1 ENSMUSG00000141763 ENSMUST00000366907.1 ENSMUSG00000141763 (from geneSymbol) uc338fgj.1 uc338fgj.1 
ENSMUST00000366909.1 ENSMUSG00000141764 ENSMUST00000366909.1 ENSMUSG00000141764 (from geneSymbol) uc338fgl.1 uc338fgl.1 
ENSMUST00000366910.1 ENSMUSG00000141765 ENSMUST00000366910.1 ENSMUSG00000141765 (from geneSymbol) uc338fgm.1 uc338fgm.1 
ENSMUST00000366911.1 ENSMUSG00000141766 ENSMUST00000366911.1 ENSMUSG00000141766 (from geneSymbol) uc338fgn.1 uc338fgn.1 
ENSMUST00000366924.1 ENSMUSG00000141767 ENSMUST00000366924.1 ENSMUSG00000141767 (from geneSymbol) uc338fha.1 uc338fha.1 
ENSMUST00000366930.1 ENSMUSG00000141768 ENSMUST00000366930.1 ENSMUSG00000141768 (from geneSymbol) uc338fhg.1 uc338fhg.1 
ENSMUST00000366932.1 ENSMUSG00000141769 ENSMUST00000366932.1 ENSMUSG00000141769 (from geneSymbol) uc338fhi.1 uc338fhi.1 
ENSMUST00000366936.1 ENSMUSG00000141770 ENSMUST00000366936.1 ENSMUSG00000141770 (from geneSymbol) uc338fhm.1 uc338fhm.1 
ENSMUST00000366937.1 ENSMUSG00000141771 ENSMUST00000366937.1 ENSMUSG00000141771 (from geneSymbol) uc338fhn.1 uc338fhn.1 
ENSMUST00000366938.1 ENSMUSG00000141772 ENSMUST00000366938.1 ENSMUSG00000141772 (from geneSymbol) uc338fho.1 uc338fho.1 
ENSMUST00000366939.1 ENSMUSG00000141773 ENSMUST00000366939.1 ENSMUSG00000141773 (from geneSymbol) uc338fhp.1 uc338fhp.1 
ENSMUST00000366943.1 ENSMUSG00000141774 ENSMUST00000366943.1 ENSMUSG00000141774 (from geneSymbol) uc338fht.1 uc338fht.1 
ENSMUST00000366947.1 Amy2b ENSMUST00000366947.1 Amy2b (from geneSymbol) M11896 uc338fhx.1 uc338fhx.1 
ENSMUST00000366986.1 Gm34799 ENSMUST00000366986.1 Gm34799 (from geneSymbol) uc338fjk.1 uc338fjk.1 
ENSMUST00000366993.1 ENSMUSG00000141776 ENSMUST00000366993.1 ENSMUSG00000141776 (from geneSymbol) uc338fjr.1 uc338fjr.1 
ENSMUST00000366997.1 C230072F16Rik ENSMUST00000366997.1 C230072F16Rik (from geneSymbol) AK087338 uc338fjv.1 uc338fjv.1 
ENSMUST00000367038.1 ENSMUSG00000141777 ENSMUST00000367038.1 ENSMUSG00000141777 (from geneSymbol) uc338flh.1 uc338flh.1 
ENSMUST00000367054.1 ENSMUSG00000141778 ENSMUST00000367054.1 ENSMUSG00000141778 (from geneSymbol) uc338flx.1 uc338flx.1 
ENSMUST00000367061.1 ENSMUSG00000141779 ENSMUST00000367061.1 ENSMUSG00000141779 (from geneSymbol) uc338fme.1 uc338fme.1 
ENSMUST00000367063.1 ENSMUSG00000141780 ENSMUST00000367063.1 ENSMUSG00000141780 (from geneSymbol) uc338fmg.1 uc338fmg.1 
ENSMUST00000367064.1 ENSMUSG00000141781 ENSMUST00000367064.1 ENSMUSG00000141781 (from geneSymbol) uc338fmh.1 uc338fmh.1 
ENSMUST00000367065.1 ENSMUSG00000141782 ENSMUST00000367065.1 ENSMUSG00000141782 (from geneSymbol) uc338fmi.1 uc338fmi.1 
ENSMUST00000367066.1 ENSMUSG00000141783 ENSMUST00000367066.1 ENSMUSG00000141783 (from geneSymbol) uc338fmj.1 uc338fmj.1 
ENSMUST00000367067.1 ENSMUSG00000141784 ENSMUST00000367067.1 ENSMUSG00000141784 (from geneSymbol) uc338fmk.1 uc338fmk.1 
ENSMUST00000367068.1 ENSMUSG00000141785 ENSMUST00000367068.1 ENSMUSG00000141785 (from geneSymbol) uc338fml.1 uc338fml.1 
ENSMUST00000367081.1 ENSMUSG00000141786 ENSMUST00000367081.1 ENSMUSG00000141786 (from geneSymbol) uc338fmy.1 uc338fmy.1 
ENSMUST00000367083.1 Gm30794 ENSMUST00000367083.1 predicted gene, 30794, transcript variant 2 (from RefSeq NR_168624.1) NR_168624 uc338fna.1 uc338fna.1 
ENSMUST00000367087.1 Gm44109 ENSMUST00000367087.1 Gm44109 (from geneSymbol) uc338fne.1 uc338fne.1 
ENSMUST00000367102.1 ENSMUSG00000141787 ENSMUST00000367102.1 ENSMUSG00000141787 (from geneSymbol) uc338fnt.1 uc338fnt.1 
ENSMUST00000367105.1 ENSMUSG00000141788 ENSMUST00000367105.1 ENSMUSG00000141788 (from geneSymbol) uc338fnw.1 uc338fnw.1 
ENSMUST00000367111.1 ENSMUSG00000141789 ENSMUST00000367111.1 ENSMUSG00000141789 (from geneSymbol) uc338foc.1 uc338foc.1 
ENSMUST00000367114.1 ENSMUSG00000141790 ENSMUST00000367114.1 ENSMUSG00000141790 (from geneSymbol) uc338fof.1 uc338fof.1 
ENSMUST00000367148.1 ENSMUSG00000141791 ENSMUST00000367148.1 ENSMUSG00000141791 (from geneSymbol) uc338fpn.1 uc338fpn.1 
ENSMUST00000367162.1 ENSMUSG00000121505 ENSMUST00000367162.1 ENSMUSG00000121505 (from geneSymbol) BC061226 uc338fqa.1 uc338fqa.1 
ENSMUST00000367238.1 Gm36742 ENSMUST00000367238.1 Gm36742 (from geneSymbol) uc338fsu.1 uc338fsu.1 
ENSMUST00000367246.1 ENSMUSG00000141792 ENSMUST00000367246.1 ENSMUSG00000141792 (from geneSymbol) uc338ftc.1 uc338ftc.1 
ENSMUST00000367248.1 ENSMUSG00000141793 ENSMUST00000367248.1 ENSMUSG00000141793 (from geneSymbol) uc338fte.1 uc338fte.1 
ENSMUST00000367249.1 Gm10941 ENSMUST00000367249.1 Gm10941 (from geneSymbol) uc338ftf.1 uc338ftf.1 
ENSMUST00000367257.1 ENSMUSG00000141794 ENSMUST00000367257.1 ENSMUSG00000141794 (from geneSymbol) uc338ftn.1 uc338ftn.1 
ENSMUST00000367258.1 ENSMUSG00000141795 ENSMUST00000367258.1 ENSMUSG00000141795 (from geneSymbol) uc338fto.1 uc338fto.1 
ENSMUST00000367259.1 ENSMUSG00000141796 ENSMUST00000367259.1 ENSMUSG00000141796 (from geneSymbol) uc338ftp.1 uc338ftp.1 
ENSMUST00000367260.1 ENSMUSG00000141797 ENSMUST00000367260.1 ENSMUSG00000141797 (from geneSymbol) uc338ftq.1 uc338ftq.1 
ENSMUST00000367263.1 ENSMUSG00000141798 ENSMUST00000367263.1 ENSMUSG00000141798 (from geneSymbol) uc338ftt.1 uc338ftt.1 
ENSMUST00000367297.1 Gm15915 ENSMUST00000367297.1 Gm15915 (from geneSymbol) AK131848 uc338fvb.1 uc338fvb.1 
ENSMUST00000367302.1 Gm56842 ENSMUST00000367302.1 Gm56842 (from geneSymbol) uc338fvf.1 uc338fvf.1 
ENSMUST00000367305.1 ENSMUSG00000141800 ENSMUST00000367305.1 ENSMUSG00000141800 (from geneSymbol) uc338fvi.1 uc338fvi.1 
ENSMUST00000367307.1 ENSMUSG00000141801 ENSMUST00000367307.1 ENSMUSG00000141801 (from geneSymbol) uc338fvk.1 uc338fvk.1 
ENSMUST00000367310.1 ENSMUSG00000141803 ENSMUST00000367310.1 ENSMUSG00000141803 (from geneSymbol) uc338fvm.1 uc338fvm.1 
ENSMUST00000367316.1 ENSMUSG00000141804 ENSMUST00000367316.1 ENSMUSG00000141804 (from geneSymbol) uc338fvs.1 uc338fvs.1 
ENSMUST00000367317.1 ENSMUSG00000141805 ENSMUST00000367317.1 ENSMUSG00000141805 (from geneSymbol) uc338fvt.1 uc338fvt.1 
ENSMUST00000367318.1 Gm49808 ENSMUST00000367318.1 Gm49808 (from geneSymbol) uc338fvu.1 uc338fvu.1 
ENSMUST00000367319.1 ENSMUSG00000141806 ENSMUST00000367319.1 ENSMUSG00000141806 (from geneSymbol) AK155266 uc338fvv.1 uc338fvv.1 
ENSMUST00000367320.1 ENSMUSG00000141807 ENSMUST00000367320.1 ENSMUSG00000141807 (from geneSymbol) uc338fvw.1 uc338fvw.1 
ENSMUST00000367322.1 ENSMUSG00000141808 ENSMUST00000367322.1 ENSMUSG00000141808 (from geneSymbol) uc338fvy.1 uc338fvy.1 
ENSMUST00000367323.1 Gm53567 ENSMUST00000367323.1 Gm53567 (from geneSymbol) uc338fvz.1 uc338fvz.1 
ENSMUST00000367334.1 ENSMUSG00000141809 ENSMUST00000367334.1 ENSMUSG00000141809 (from geneSymbol) uc338fwj.1 uc338fwj.1 
ENSMUST00000367342.1 ENSMUSG00000141810 ENSMUST00000367342.1 ENSMUSG00000141810 (from geneSymbol) uc338fwr.1 uc338fwr.1 
ENSMUST00000367343.1 ENSMUSG00000141811 ENSMUST00000367343.1 ENSMUSG00000141811 (from geneSymbol) uc338fws.1 uc338fws.1 
ENSMUST00000367344.1 ENSMUSG00000141812 ENSMUST00000367344.1 ENSMUSG00000141812 (from geneSymbol) uc338fwt.1 uc338fwt.1 
ENSMUST00000367346.1 ENSMUSG00000141813 ENSMUST00000367346.1 ENSMUSG00000141813 (from geneSymbol) uc338fwv.1 uc338fwv.1 
ENSMUST00000367348.1 ENSMUSG00000141814 ENSMUST00000367348.1 ENSMUSG00000141814 (from geneSymbol) uc338fwx.1 uc338fwx.1 
ENSMUST00000367349.1 ENSMUSG00000141815 ENSMUST00000367349.1 ENSMUSG00000141815 (from geneSymbol) uc338fwy.1 uc338fwy.1 
ENSMUST00000367358.1 ENSMUSG00000141816 ENSMUST00000367358.1 ENSMUSG00000141816 (from geneSymbol) uc338fxh.1 uc338fxh.1 
ENSMUST00000367360.1 ENSMUSG00000141817 ENSMUST00000367360.1 ENSMUSG00000141817 (from geneSymbol) uc338fxj.1 uc338fxj.1 
ENSMUST00000367361.1 ENSMUSG00000141818 ENSMUST00000367361.1 ENSMUSG00000141818 (from geneSymbol) uc338fxk.1 uc338fxk.1 
ENSMUST00000367362.1 ENSMUSG00000141819 ENSMUST00000367362.1 ENSMUSG00000141819 (from geneSymbol) uc338fxl.1 uc338fxl.1 
ENSMUST00000367365.1 2310001H17Rik ENSMUST00000367365.1 2310001H17Rik (from geneSymbol) uc338fxo.1 uc338fxo.1 
ENSMUST00000367524.1 ENSMUSG00000141820 ENSMUST00000367524.1 ENSMUSG00000141820 (from geneSymbol) uc338gdq.1 uc338gdq.1 
ENSMUST00000367525.1 Gm34397 ENSMUST00000367525.1 Gm34397 (from geneSymbol) uc338gdr.1 uc338gdr.1 
ENSMUST00000367530.1 ENSMUSG00000141821 ENSMUST00000367530.1 ENSMUSG00000141821 (from geneSymbol) uc338gdw.1 uc338gdw.1 
ENSMUST00000367531.1 Gm57165 ENSMUST00000367531.1 Gm57165 (from geneSymbol) uc338gdx.1 uc338gdx.1 
ENSMUST00000367541.1 ENSMUSG00000141823 ENSMUST00000367541.1 ENSMUSG00000141823 (from geneSymbol) uc338geg.1 uc338geg.1 
ENSMUST00000367542.1 ENSMUSG00000141824 ENSMUST00000367542.1 ENSMUSG00000141824 (from geneSymbol) uc338geh.1 uc338geh.1 
ENSMUST00000367543.1 ENSMUSG00000141825 ENSMUST00000367543.1 ENSMUSG00000141825 (from geneSymbol) LF274875 uc338gei.1 uc338gei.1 
ENSMUST00000367544.1 ENSMUSG00000141826 ENSMUST00000367544.1 ENSMUSG00000141826 (from geneSymbol) uc338gej.1 uc338gej.1 
ENSMUST00000367545.1 Gm48023 ENSMUST00000367545.1 Gm48023 (from geneSymbol) uc338gek.1 uc338gek.1 
ENSMUST00000367563.1 ENSMUSG00000141827 ENSMUST00000367563.1 ENSMUSG00000141827 (from geneSymbol) uc338gfc.1 uc338gfc.1 
ENSMUST00000367564.1 ENSMUSG00000141828 ENSMUST00000367564.1 ENSMUSG00000141828 (from geneSymbol) uc338gfd.1 uc338gfd.1 
ENSMUST00000367565.1 ENSMUSG00000141829 ENSMUST00000367565.1 ENSMUSG00000141829 (from geneSymbol) uc338gfe.1 uc338gfe.1 
ENSMUST00000367567.1 ENSMUSG00000141830 ENSMUST00000367567.1 ENSMUSG00000141830 (from geneSymbol) uc338gfg.1 uc338gfg.1 
ENSMUST00000367571.1 ENSMUSG00000141831 ENSMUST00000367571.1 ENSMUSG00000141831 (from geneSymbol) uc338gfk.1 uc338gfk.1 
ENSMUST00000367573.1 ENSMUSG00000141832 ENSMUST00000367573.1 ENSMUSG00000141832 (from geneSymbol) uc338gfm.1 uc338gfm.1 
ENSMUST00000367574.1 ENSMUSG00000141833 ENSMUST00000367574.1 ENSMUSG00000141833 (from geneSymbol) uc338gfn.1 uc338gfn.1 
ENSMUST00000367575.1 ENSMUSG00000141834 ENSMUST00000367575.1 ENSMUSG00000141834 (from geneSymbol) uc338gfo.1 uc338gfo.1 
ENSMUST00000367577.1 ENSMUSG00000141835 ENSMUST00000367577.1 ENSMUSG00000141835 (from geneSymbol) uc338gfq.1 uc338gfq.1 
ENSMUST00000367580.1 ENSMUSG00000141836 ENSMUST00000367580.1 ENSMUSG00000141836 (from geneSymbol) uc338gft.1 uc338gft.1 
ENSMUST00000367581.1 ENSMUSG00000141837 ENSMUST00000367581.1 ENSMUSG00000141837 (from geneSymbol) uc338gfu.1 uc338gfu.1 
ENSMUST00000367586.1 Gm30563 ENSMUST00000367586.1 Gm30563 (from geneSymbol) uc338gfz.1 uc338gfz.1 
ENSMUST00000367589.1 ENSMUSG00000141838 ENSMUST00000367589.1 ENSMUSG00000141838 (from geneSymbol) uc338ggb.1 uc338ggb.1 
ENSMUST00000367591.1 ENSMUSG00000141839 ENSMUST00000367591.1 ENSMUSG00000141839 (from geneSymbol) uc338ggd.1 uc338ggd.1 
ENSMUST00000367595.1 ENSMUSG00000141840 ENSMUST00000367595.1 ENSMUSG00000141840 (from geneSymbol) uc338ggh.1 uc338ggh.1 
ENSMUST00000367598.1 ENSMUSG00000141841 ENSMUST00000367598.1 ENSMUSG00000141841 (from geneSymbol) uc338ggk.1 uc338ggk.1 
ENSMUST00000367601.1 ENSMUSG00000141842 ENSMUST00000367601.1 ENSMUSG00000141842 (from geneSymbol) uc338ggn.1 uc338ggn.1 
ENSMUST00000367602.1 ENSMUSG00000141843 ENSMUST00000367602.1 ENSMUSG00000141843 (from geneSymbol) uc338ggo.1 uc338ggo.1 
ENSMUST00000367607.1 ENSMUSG00000121687 ENSMUST00000367607.1 ENSMUSG00000121687 (from geneSymbol) uc338ggt.1 uc338ggt.1 
ENSMUST00000367613.1 Gm16316 ENSMUST00000367613.1 Gm16316 (from geneSymbol) AK143479 uc338ggy.1 uc338ggy.1 
ENSMUST00000367615.1 1700020N18Rik ENSMUST00000367615.1 1700020N18Rik (from geneSymbol) AK006756 uc338gha.1 uc338gha.1 
ENSMUST00000367621.1 ENSMUSG00000141845 ENSMUST00000367621.1 ENSMUSG00000141845 (from geneSymbol) uc338ghg.1 uc338ghg.1 
ENSMUST00000367624.1 ENSMUSG00000141846 ENSMUST00000367624.1 ENSMUSG00000141846 (from geneSymbol) uc338ghj.1 uc338ghj.1 
ENSMUST00000367626.1 ENSMUSG00000141847 ENSMUST00000367626.1 ENSMUSG00000141847 (from geneSymbol) uc338ghl.1 uc338ghl.1 
ENSMUST00000367627.1 ENSMUSG00000141848 ENSMUST00000367627.1 ENSMUSG00000141848 (from geneSymbol) uc338ghm.1 uc338ghm.1 
ENSMUST00000367629.1 ENSMUSG00000141849 ENSMUST00000367629.1 ENSMUSG00000141849 (from geneSymbol) uc338gho.1 uc338gho.1 
ENSMUST00000367630.1 Gm29283 ENSMUST00000367630.1 Gm29283 (from geneSymbol) uc338ghp.1 uc338ghp.1 
ENSMUST00000367637.1 ENSMUSG00000141850 ENSMUST00000367637.1 ENSMUSG00000141850 (from geneSymbol) uc338ghw.1 uc338ghw.1 
ENSMUST00000367644.1 ENSMUSG00000141851 ENSMUST00000367644.1 ENSMUSG00000141851 (from geneSymbol) uc338gid.1 uc338gid.1 
ENSMUST00000367648.1 Gm35963 ENSMUST00000367648.1 Gm35963 (from geneSymbol) uc338gih.1 uc338gih.1 
ENSMUST00000367652.1 ENSMUSG00000141852 ENSMUST00000367652.1 ENSMUSG00000141852 (from geneSymbol) uc338gil.1 uc338gil.1 
ENSMUST00000367663.1 ENSMUSG00000141853 ENSMUST00000367663.1 ENSMUSG00000141853 (from geneSymbol) uc338gio.1 uc338gio.1 
ENSMUST00000367669.1 ENSMUSG00000141854 ENSMUST00000367669.1 ENSMUSG00000141854 (from geneSymbol) AK006169 uc338giu.1 uc338giu.1 
ENSMUST00000367670.1 ENSMUSG00000141855 ENSMUST00000367670.1 ENSMUSG00000141855 (from geneSymbol) uc338giv.1 uc338giv.1 
ENSMUST00000367674.1 ENSMUSG00000141856 ENSMUST00000367674.1 ENSMUSG00000141856 (from geneSymbol) BC005505 uc338giz.1 uc338giz.1 
ENSMUST00000367681.1 ENSMUSG00000141857 ENSMUST00000367681.1 ENSMUSG00000141857 (from geneSymbol) uc338gjg.1 uc338gjg.1 
ENSMUST00000367682.1 ENSMUSG00000141858 ENSMUST00000367682.1 ENSMUSG00000141858 (from geneSymbol) uc338gjh.1 uc338gjh.1 
ENSMUST00000367687.1 ENSMUSG00000141859 ENSMUST00000367687.1 ENSMUSG00000141859 (from geneSymbol) uc338gjm.1 uc338gjm.1 
ENSMUST00000367691.1 ENSMUSG00000141860 ENSMUST00000367691.1 ENSMUSG00000141860 (from geneSymbol) uc338gjq.1 uc338gjq.1 
ENSMUST00000367692.1 ENSMUSG00000141861 ENSMUST00000367692.1 ENSMUSG00000141861 (from geneSymbol) uc338gjr.1 uc338gjr.1 
ENSMUST00000367693.1 ENSMUSG00000141862 ENSMUST00000367693.1 ENSMUSG00000141862 (from geneSymbol) uc338gjs.1 uc338gjs.1 
ENSMUST00000367695.1 ENSMUSG00000141863 ENSMUST00000367695.1 ENSMUSG00000141863 (from geneSymbol) uc338gju.1 uc338gju.1 
ENSMUST00000367696.1 ENSMUSG00000141864 ENSMUST00000367696.1 ENSMUSG00000141864 (from geneSymbol) uc338gjv.1 uc338gjv.1 
ENSMUST00000367704.1 Gm47814 ENSMUST00000367704.1 Gm47814 (from geneSymbol) uc338gkd.1 uc338gkd.1 
ENSMUST00000367743.1 ENSMUSG00000141865 ENSMUST00000367743.1 ENSMUSG00000141865 (from geneSymbol) uc338glq.1 uc338glq.1 
ENSMUST00000367744.1 ENSMUSG00000141866 ENSMUST00000367744.1 ENSMUSG00000141866 (from geneSymbol) uc338glr.1 uc338glr.1 
ENSMUST00000367745.1 ENSMUSG00000141867 ENSMUST00000367745.1 ENSMUSG00000141867 (from geneSymbol) uc338gls.1 uc338gls.1 
ENSMUST00000367746.1 ENSMUSG00000141868 ENSMUST00000367746.1 ENSMUSG00000141868 (from geneSymbol) uc338glt.1 uc338glt.1 
ENSMUST00000367748.1 Gm47861 ENSMUST00000367748.1 Gm47861 (from geneSymbol) uc338glv.1 uc338glv.1 
ENSMUST00000367774.1 ENSMUSG00000141869 ENSMUST00000367774.1 ENSMUSG00000141869 (from geneSymbol) uc338gmv.1 uc338gmv.1 
ENSMUST00000367778.1 ENSMUSG00000141870 ENSMUST00000367778.1 ENSMUSG00000141870 (from geneSymbol) uc338gmz.1 uc338gmz.1 
ENSMUST00000367779.1 ENSMUSG00000141871 ENSMUST00000367779.1 ENSMUSG00000141871 (from geneSymbol) uc338gna.1 uc338gna.1 
ENSMUST00000367781.1 ENSMUSG00000141872 ENSMUST00000367781.1 ENSMUSG00000141872 (from geneSymbol) uc338gnc.1 uc338gnc.1 
ENSMUST00000367783.1 4932702P03Rik ENSMUST00000367783.1 4932702P03Rik (from geneSymbol) AK016580 uc338gne.1 uc338gne.1 
ENSMUST00000367791.1 ENSMUSG00000141873 ENSMUST00000367791.1 ENSMUSG00000141873 (from geneSymbol) uc338gnm.1 uc338gnm.1 
ENSMUST00000367792.1 ENSMUSG00000141874 ENSMUST00000367792.1 ENSMUSG00000141874 (from geneSymbol) uc338gnn.1 uc338gnn.1 
ENSMUST00000367793.1 ENSMUSG00000141875 ENSMUST00000367793.1 ENSMUSG00000141875 (from geneSymbol) BC128317 uc338gno.1 uc338gno.1 
ENSMUST00000367794.1 4930564D02Rik ENSMUST00000367794.1 4930564D02Rik (from geneSymbol) AK016218 uc338gnp.1 uc338gnp.1 
ENSMUST00000367816.1 ENSMUSG00000141876 ENSMUST00000367816.1 ENSMUSG00000141876 (from geneSymbol) uc338gol.1 uc338gol.1 
ENSMUST00000367818.1 ENSMUSG00000141878 ENSMUST00000367818.1 ENSMUSG00000141878 (from geneSymbol) uc338gom.1 uc338gom.1 
ENSMUST00000367819.1 ENSMUSG00000141879 ENSMUST00000367819.1 ENSMUSG00000141879 (from geneSymbol) uc338gon.1 uc338gon.1 
ENSMUST00000367822.1 Gm28609 ENSMUST00000367822.1 Gm28609 (from geneSymbol) KY467509 uc338goq.1 uc338goq.1 
ENSMUST00000367838.1 Gm16092 ENSMUST00000367838.1 Gm16092 (from geneSymbol) BC071209 uc338gpg.1 uc338gpg.1 
ENSMUST00000367840.1 ENSMUSG00000141880 ENSMUST00000367840.1 ENSMUSG00000141880 (from geneSymbol) uc338gpi.1 uc338gpi.1 
ENSMUST00000367849.1 Gm44649 ENSMUST00000367849.1 Gm44649 (from geneSymbol) AK006397 uc338gpr.1 uc338gpr.1 
ENSMUST00000367861.1 ENSMUSG00000141881 ENSMUST00000367861.1 ENSMUSG00000141881 (from geneSymbol) uc338gqd.1 uc338gqd.1 
ENSMUST00000367862.1 ENSMUSG00000141882 ENSMUST00000367862.1 ENSMUSG00000141882 (from geneSymbol) uc338gqe.1 uc338gqe.1 
ENSMUST00000367864.1 ENSMUSG00000141883 ENSMUST00000367864.1 ENSMUSG00000141883 (from geneSymbol) uc338gqg.1 uc338gqg.1 
ENSMUST00000367883.1 ENSMUSG00000141884 ENSMUST00000367883.1 ENSMUSG00000141884 (from geneSymbol) uc338gqz.1 uc338gqz.1 
ENSMUST00000367885.1 9430093N23Rik ENSMUST00000367885.1 9430093N23Rik (from geneSymbol) AK020520 uc338grb.1 uc338grb.1 
ENSMUST00000367894.1 ENSMUSG00000141885 ENSMUST00000367894.1 ENSMUSG00000141885 (from geneSymbol) uc338grk.1 uc338grk.1 
ENSMUST00000367895.1 ENSMUSG00000141886 ENSMUST00000367895.1 ENSMUSG00000141886 (from geneSymbol) uc338grl.1 uc338grl.1 
ENSMUST00000367896.1 ENSMUSG00000141887 ENSMUST00000367896.1 ENSMUSG00000141887 (from geneSymbol) uc338grm.1 uc338grm.1 
ENSMUST00000367898.1 ENSMUSG00000141888 ENSMUST00000367898.1 ENSMUSG00000141888 (from geneSymbol) uc338gro.1 uc338gro.1 
ENSMUST00000367899.1 Gm16897 ENSMUST00000367899.1 Gm16897 (from geneSymbol) AK030377 uc338grp.1 uc338grp.1 
ENSMUST00000367914.1 ENSMUSG00000141889 ENSMUST00000367914.1 ENSMUSG00000141889 (from geneSymbol) AK076914 uc338gse.1 uc338gse.1 
ENSMUST00000367920.1 ENSMUSG00000141892 ENSMUST00000367920.1 ENSMUSG00000141892 (from geneSymbol) uc338gsi.1 uc338gsi.1 
ENSMUST00000367933.1 ENSMUSG00000141893 ENSMUST00000367933.1 ENSMUSG00000141893 (from geneSymbol) uc338gsv.1 uc338gsv.1 
ENSMUST00000367936.1 ENSMUSG00000141894 ENSMUST00000367936.1 ENSMUSG00000141894 (from geneSymbol) uc338gsy.1 uc338gsy.1 
ENSMUST00000367940.1 ENSMUSG00000141895 ENSMUST00000367940.1 ENSMUSG00000141895 (from geneSymbol) KY467490 uc338gtc.1 uc338gtc.1 
ENSMUST00000367954.1 ENSMUSG00000141896 ENSMUST00000367954.1 ENSMUSG00000141896 (from geneSymbol) uc338gtq.1 uc338gtq.1 
ENSMUST00000367956.1 ENSMUSG00000141897 ENSMUST00000367956.1 ENSMUSG00000141897 (from geneSymbol) uc338gts.1 uc338gts.1 
ENSMUST00000367958.1 ENSMUSG00000141898 ENSMUST00000367958.1 ENSMUSG00000141898 (from geneSymbol) uc338gtu.1 uc338gtu.1 
ENSMUST00000367959.1 ENSMUSG00000141899 ENSMUST00000367959.1 ENSMUSG00000141899 (from geneSymbol) uc338gtv.1 uc338gtv.1 
ENSMUST00000367960.1 ENSMUSG00000141900 ENSMUST00000367960.1 ENSMUSG00000141900 (from geneSymbol) uc338gtw.1 uc338gtw.1 
ENSMUST00000367993.1 ENSMUSG00000141901 ENSMUST00000367993.1 ENSMUSG00000141901 (from geneSymbol) uc338gvd.1 uc338gvd.1 
ENSMUST00000367999.1 ENSMUSG00000141902 ENSMUST00000367999.1 ENSMUSG00000141902 (from geneSymbol) uc338gvj.1 uc338gvj.1 
ENSMUST00000368004.1 ENSMUSG00000141903 ENSMUST00000368004.1 ENSMUSG00000141903 (from geneSymbol) uc338gvo.1 uc338gvo.1 
ENSMUST00000368005.1 ENSMUSG00000141904 ENSMUST00000368005.1 ENSMUSG00000141904 (from geneSymbol) uc338gvp.1 uc338gvp.1 
ENSMUST00000368007.1 ENSMUSG00000141905 ENSMUST00000368007.1 ENSMUSG00000141905 (from geneSymbol) uc338gvr.1 uc338gvr.1 
ENSMUST00000368010.1 ENSMUSG00000141906 ENSMUST00000368010.1 ENSMUSG00000141906 (from geneSymbol) uc338gvu.1 uc338gvu.1 
ENSMUST00000368011.1 ENSMUSG00000141907 ENSMUST00000368011.1 ENSMUSG00000141907 (from geneSymbol) uc338gvv.1 uc338gvv.1 
ENSMUST00000368013.1 ENSMUSG00000141908 ENSMUST00000368013.1 ENSMUSG00000141908 (from geneSymbol) uc338gvx.1 uc338gvx.1 
ENSMUST00000368018.1 ENSMUSG00000141909 ENSMUST00000368018.1 ENSMUSG00000141909 (from geneSymbol) uc338gwc.1 uc338gwc.1 
ENSMUST00000368020.1 ENSMUSG00000141910 ENSMUST00000368020.1 ENSMUSG00000141910 (from geneSymbol) uc338gwe.1 uc338gwe.1 
ENSMUST00000368021.1 ENSMUSG00000141911 ENSMUST00000368021.1 ENSMUSG00000141911 (from geneSymbol) uc338gwf.1 uc338gwf.1 
ENSMUST00000368023.1 ENSMUSG00000141912 ENSMUST00000368023.1 ENSMUSG00000141912 (from geneSymbol) uc338gwh.1 uc338gwh.1 
ENSMUST00000368027.1 ENSMUSG00000141913 ENSMUST00000368027.1 ENSMUSG00000141913 (from geneSymbol) AK132972 uc338gwl.1 uc338gwl.1 
ENSMUST00000368037.1 ENSMUSG00000141914 ENSMUST00000368037.1 ENSMUSG00000141914 (from geneSymbol) uc338gwv.1 uc338gwv.1 
ENSMUST00000368039.1 ENSMUSG00000141915 ENSMUST00000368039.1 ENSMUSG00000141915 (from geneSymbol) uc338gwx.1 uc338gwx.1 
ENSMUST00000368041.1 ENSMUSG00000141916 ENSMUST00000368041.1 ENSMUSG00000141916 (from geneSymbol) uc338gwz.1 uc338gwz.1 
ENSMUST00000368042.1 ENSMUSG00000141917 ENSMUST00000368042.1 ENSMUSG00000141917 (from geneSymbol) uc338gxa.1 uc338gxa.1 
ENSMUST00000368046.1 Gm26705 ENSMUST00000368046.1 Gm26705 (from geneSymbol) uc338gxc.1 uc338gxc.1 
ENSMUST00000368047.1 ENSMUSG00000141919 ENSMUST00000368047.1 ENSMUSG00000141919 (from geneSymbol) uc338gxd.1 uc338gxd.1 
ENSMUST00000368051.1 ENSMUSG00000141920 ENSMUST00000368051.1 ENSMUSG00000141920 (from geneSymbol) uc338gxh.1 uc338gxh.1 
ENSMUST00000368052.1 ENSMUSG00000141921 ENSMUST00000368052.1 ENSMUSG00000141921 (from geneSymbol) uc338gxi.1 uc338gxi.1 
ENSMUST00000368053.1 ENSMUSG00000141922 ENSMUST00000368053.1 ENSMUSG00000141922 (from geneSymbol) uc338gxj.1 uc338gxj.1 
ENSMUST00000368054.1 ENSMUSG00000141923 ENSMUST00000368054.1 ENSMUSG00000141923 (from geneSymbol) uc338gxk.1 uc338gxk.1 
ENSMUST00000368055.1 ENSMUSG00000141924 ENSMUST00000368055.1 ENSMUSG00000141924 (from geneSymbol) uc338gxl.1 uc338gxl.1 
ENSMUST00000368057.1 ENSMUSG00000141925 ENSMUST00000368057.1 ENSMUSG00000141925 (from geneSymbol) uc338gxn.1 uc338gxn.1 
ENSMUST00000368061.1 ENSMUSG00000141926 ENSMUST00000368061.1 ENSMUSG00000141926 (from geneSymbol) uc338gxr.1 uc338gxr.1 
ENSMUST00000368062.1 Gm7762 ENSMUST00000368062.1 Gm7762 (from geneSymbol) uc338gxs.1 uc338gxs.1 
ENSMUST00000368066.1 ENSMUSG00000141927 ENSMUST00000368066.1 ENSMUSG00000141927 (from geneSymbol) uc338gxw.1 uc338gxw.1 
ENSMUST00000368068.1 ENSMUSG00000141928 ENSMUST00000368068.1 ENSMUSG00000141928 (from geneSymbol) uc338gxy.1 uc338gxy.1 
ENSMUST00000368070.1 ENSMUSG00000141929 ENSMUST00000368070.1 ENSMUSG00000141929 (from geneSymbol) uc338gya.1 uc338gya.1 
ENSMUST00000368071.1 ENSMUSG00000141930 ENSMUST00000368071.1 ENSMUSG00000141930 (from geneSymbol) uc338gyb.1 uc338gyb.1 
ENSMUST00000368072.1 ENSMUSG00000141931 ENSMUST00000368072.1 ENSMUSG00000141931 (from geneSymbol) uc338gyc.1 uc338gyc.1 
ENSMUST00000368075.1 ENSMUSG00000141932 ENSMUST00000368075.1 ENSMUSG00000141932 (from geneSymbol) uc338gyf.1 uc338gyf.1 
ENSMUST00000368076.1 ENSMUSG00000141933 ENSMUST00000368076.1 ENSMUSG00000141933 (from geneSymbol) uc338gyg.1 uc338gyg.1 
ENSMUST00000368095.1 ENSMUSG00000141934 ENSMUST00000368095.1 ENSMUSG00000141934 (from geneSymbol) uc338gyz.1 uc338gyz.1 
ENSMUST00000368096.1 A330023F24Rik ENSMUST00000368096.1 A330023F24Rik (from geneSymbol) AK171382 uc338gza.1 uc338gza.1 
ENSMUST00000368119.1 ENSMUSG00000141935 ENSMUST00000368119.1 ENSMUSG00000141935 (from geneSymbol) uc338gzu.1 uc338gzu.1 
ENSMUST00000368120.1 ENSMUSG00000141936 ENSMUST00000368120.1 ENSMUSG00000141936 (from geneSymbol) uc338gzv.1 uc338gzv.1 
ENSMUST00000368130.1 ENSMUSG00000141937 ENSMUST00000368130.1 ENSMUSG00000141937 (from geneSymbol) uc338haf.1 uc338haf.1 
ENSMUST00000368142.1 ENSMUSG00000141939 ENSMUST00000368142.1 ENSMUSG00000141939 (from geneSymbol) uc338haq.1 uc338haq.1 
ENSMUST00000368144.1 ENSMUSG00000141940 ENSMUST00000368144.1 ENSMUSG00000141940 (from geneSymbol) uc338has.1 uc338has.1 
ENSMUST00000368145.1 Gm12963 ENSMUST00000368145.1 Gm12963 (from geneSymbol) uc338hat.1 uc338hat.1 
ENSMUST00000368152.1 ENSMUSG00000141941 ENSMUST00000368152.1 ENSMUSG00000141941 (from geneSymbol) uc338hba.1 uc338hba.1 
ENSMUST00000368153.1 ENSMUSG00000141942 ENSMUST00000368153.1 ENSMUSG00000141942 (from geneSymbol) uc338hbb.1 uc338hbb.1 
ENSMUST00000368154.1 ENSMUSG00000141943 ENSMUST00000368154.1 ENSMUSG00000141943 (from geneSymbol) uc338hbc.1 uc338hbc.1 
ENSMUST00000368155.1 Gm56754 ENSMUST00000368155.1 Gm56754 (from geneSymbol) uc338hbd.1 uc338hbd.1 
ENSMUST00000368156.1 ENSMUSG00000141944 ENSMUST00000368156.1 ENSMUSG00000141944 (from geneSymbol) uc338hbe.1 uc338hbe.1 
ENSMUST00000368160.1 ENSMUSG00000141945 ENSMUST00000368160.1 ENSMUSG00000141945 (from geneSymbol) uc338hbi.1 uc338hbi.1 
ENSMUST00000368163.1 ENSMUSG00000141946 ENSMUST00000368163.1 ENSMUSG00000141946 (from geneSymbol) uc338hbl.1 uc338hbl.1 
ENSMUST00000368168.1 ENSMUSG00000141947 ENSMUST00000368168.1 ENSMUSG00000141947 (from geneSymbol) uc338hbq.1 uc338hbq.1 
ENSMUST00000368169.1 ENSMUSG00000141948 ENSMUST00000368169.1 ENSMUSG00000141948 (from geneSymbol) uc338hbr.1 uc338hbr.1 
ENSMUST00000368170.1 ENSMUSG00000141949 ENSMUST00000368170.1 ENSMUSG00000141949 (from geneSymbol) uc338hbs.1 uc338hbs.1 
ENSMUST00000368172.1 ENSMUSG00000141950 ENSMUST00000368172.1 ENSMUSG00000141950 (from geneSymbol) uc338hbu.1 uc338hbu.1 
ENSMUST00000368174.1 ENSMUSG00000141951 ENSMUST00000368174.1 ENSMUSG00000141951 (from geneSymbol) uc338hbw.1 uc338hbw.1 
ENSMUST00000368180.1 ENSMUSG00000141952 ENSMUST00000368180.1 ENSMUSG00000141952 (from geneSymbol) uc338hcc.1 uc338hcc.1 
ENSMUST00000368182.1 ENSMUSG00000141953 ENSMUST00000368182.1 ENSMUSG00000141953 (from geneSymbol) uc338hce.1 uc338hce.1 
ENSMUST00000368183.1 ENSMUSG00000141954 ENSMUST00000368183.1 ENSMUSG00000141954 (from geneSymbol) uc338hcf.1 uc338hcf.1 
ENSMUST00000368184.1 1700012J15Rik ENSMUST00000368184.1 1700012J15Rik (from geneSymbol) AK005916 uc338hcg.1 uc338hcg.1 
ENSMUST00000368207.1 ENSMUSG00000141955 ENSMUST00000368207.1 ENSMUSG00000141955 (from geneSymbol) uc338hdc.1 uc338hdc.1 
ENSMUST00000368210.1 ENSMUSG00000141957 ENSMUST00000368210.1 ENSMUSG00000141957 (from geneSymbol) uc338hdd.1 uc338hdd.1 
ENSMUST00000368211.1 ENSMUSG00000141958 ENSMUST00000368211.1 ENSMUSG00000141958 (from geneSymbol) uc338hde.1 uc338hde.1 
ENSMUST00000368212.1 ENSMUSG00000141959 ENSMUST00000368212.1 ENSMUSG00000141959 (from geneSymbol) uc338hdf.1 uc338hdf.1 
ENSMUST00000368213.1 ENSMUSG00000141960 ENSMUST00000368213.1 ENSMUSG00000141960 (from geneSymbol) uc338hdg.1 uc338hdg.1 
ENSMUST00000368216.1 ENSMUSG00000141961 ENSMUST00000368216.1 ENSMUSG00000141961 (from geneSymbol) uc338hdj.1 uc338hdj.1 
ENSMUST00000368217.1 Gm15600 ENSMUST00000368217.1 Gm15600 (from geneSymbol) AK041975 uc338hdk.1 uc338hdk.1 
ENSMUST00000368219.1 ENSMUSG00000141962 ENSMUST00000368219.1 ENSMUSG00000141962 (from geneSymbol) uc338hdm.1 uc338hdm.1 
ENSMUST00000368221.1 ENSMUSG00000141963 ENSMUST00000368221.1 ENSMUSG00000141963 (from geneSymbol) uc338hdo.1 uc338hdo.1 
ENSMUST00000368222.1 ENSMUSG00000141964 ENSMUST00000368222.1 ENSMUSG00000141964 (from geneSymbol) uc338hdp.1 uc338hdp.1 
ENSMUST00000368225.1 ENSMUSG00000141965 ENSMUST00000368225.1 ENSMUSG00000141965 (from geneSymbol) uc338hds.1 uc338hds.1 
ENSMUST00000368226.1 ENSMUSG00000141966 ENSMUST00000368226.1 ENSMUSG00000141966 (from geneSymbol) uc338hdt.1 uc338hdt.1 
ENSMUST00000368230.1 ENSMUSG00000141967 ENSMUST00000368230.1 ENSMUSG00000141967 (from geneSymbol) uc338hdx.1 uc338hdx.1 
ENSMUST00000368231.1 ENSMUSG00000141968 ENSMUST00000368231.1 ENSMUSG00000141968 (from geneSymbol) uc338hdy.1 uc338hdy.1 
ENSMUST00000368232.1 ENSMUSG00000141969 ENSMUST00000368232.1 ENSMUSG00000141969 (from geneSymbol) uc338hdz.1 uc338hdz.1 
ENSMUST00000368237.1 ENSMUSG00000141970 ENSMUST00000368237.1 ENSMUSG00000141970 (from geneSymbol) uc338hee.1 uc338hee.1 
ENSMUST00000368240.1 ENSMUSG00000141972 ENSMUST00000368240.1 ENSMUSG00000141972 (from geneSymbol) uc338heg.1 uc338heg.1 
ENSMUST00000368244.1 5730471H19Rik ENSMUST00000368244.1 5730471H19Rik (from geneSymbol) uc338hek.1 uc338hek.1 
ENSMUST00000368268.1 ENSMUSG00000141973 ENSMUST00000368268.1 ENSMUSG00000141973 (from geneSymbol) uc338hfi.1 uc338hfi.1 
ENSMUST00000368269.1 ENSMUSG00000141974 ENSMUST00000368269.1 ENSMUSG00000141974 (from geneSymbol) uc338hfj.1 uc338hfj.1 
ENSMUST00000368272.1 ENSMUSG00000141975 ENSMUST00000368272.1 ENSMUSG00000141975 (from geneSymbol) uc338hfm.1 uc338hfm.1 
ENSMUST00000368274.1 ENSMUSG00000141976 ENSMUST00000368274.1 ENSMUSG00000141976 (from geneSymbol) uc338hfo.1 uc338hfo.1 
ENSMUST00000368275.1 ENSMUSG00000141977 ENSMUST00000368275.1 ENSMUSG00000141977 (from geneSymbol) uc338hfp.1 uc338hfp.1 
ENSMUST00000368280.1 ENSMUSG00000141979 ENSMUST00000368280.1 ENSMUSG00000141979 (from geneSymbol) uc338hft.1 uc338hft.1 
ENSMUST00000368281.1 ENSMUSG00000141980 ENSMUST00000368281.1 ENSMUSG00000141980 (from geneSymbol) uc338hfu.1 uc338hfu.1 
ENSMUST00000368283.1 Gm39468 ENSMUST00000368283.1 Gm39468 (from geneSymbol) uc338hfw.1 uc338hfw.1 
ENSMUST00000368296.1 4930523O13Rik ENSMUST00000368296.1 4930523O13Rik (from geneSymbol) AK015877 uc338hgj.1 uc338hgj.1 
ENSMUST00000368321.1 ENSMUSG00000141981 ENSMUST00000368321.1 ENSMUSG00000141981 (from geneSymbol) uc338hhh.1 uc338hhh.1 
ENSMUST00000368326.1 ENSMUSG00000141982 ENSMUST00000368326.1 ENSMUSG00000141982 (from geneSymbol) uc338hhm.1 uc338hhm.1 
ENSMUST00000368327.1 4930434O05Rik ENSMUST00000368327.1 4930434O05Rik (from geneSymbol) uc338hhn.1 uc338hhn.1 
ENSMUST00000368328.1 ENSMUSG00000141983 ENSMUST00000368328.1 ENSMUSG00000141983 (from geneSymbol) uc338hho.1 uc338hho.1 
ENSMUST00000368329.1 ENSMUSG00000141984 ENSMUST00000368329.1 ENSMUSG00000141984 (from geneSymbol) uc338hhp.1 uc338hhp.1 
ENSMUST00000368334.1 ENSMUSG00000141985 ENSMUST00000368334.1 ENSMUSG00000141985 (from geneSymbol) uc338hhu.1 uc338hhu.1 
ENSMUST00000368335.1 ENSMUSG00000141986 ENSMUST00000368335.1 ENSMUSG00000141986 (from geneSymbol) uc338hhv.1 uc338hhv.1 
ENSMUST00000368336.1 ENSMUSG00000141987 ENSMUST00000368336.1 ENSMUSG00000141987 (from geneSymbol) uc338hhw.1 uc338hhw.1 
ENSMUST00000368340.1 ENSMUSG00000141988 ENSMUST00000368340.1 ENSMUSG00000141988 (from geneSymbol) uc338hia.1 uc338hia.1 
ENSMUST00000368341.1 ENSMUSG00000141989 ENSMUST00000368341.1 ENSMUSG00000141989 (from geneSymbol) uc338hib.1 uc338hib.1 
ENSMUST00000368342.1 ENSMUSG00000141990 ENSMUST00000368342.1 ENSMUSG00000141990 (from geneSymbol) uc338hic.1 uc338hic.1 
ENSMUST00000368343.1 ENSMUSG00000141991 ENSMUST00000368343.1 ENSMUSG00000141991 (from geneSymbol) uc338hid.1 uc338hid.1 
ENSMUST00000368349.1 ENSMUSG00000141992 ENSMUST00000368349.1 ENSMUSG00000141992 (from geneSymbol) uc338hij.1 uc338hij.1 
ENSMUST00000368350.1 ENSMUSG00000141993 ENSMUST00000368350.1 ENSMUSG00000141993 (from geneSymbol) uc338hik.1 uc338hik.1 
ENSMUST00000368352.1 Gm35194 ENSMUST00000368352.1 Gm35194 (from geneSymbol) uc338him.1 uc338him.1 
ENSMUST00000368364.1 1700030C14Rik ENSMUST00000368364.1 1700030C14Rik (from geneSymbol) AK006531 uc338hiy.1 uc338hiy.1 
ENSMUST00000368371.1 ENSMUSG00000141995 ENSMUST00000368371.1 ENSMUSG00000141995 (from geneSymbol) uc338hjf.1 uc338hjf.1 
ENSMUST00000368373.1 ENSMUSG00000141996 ENSMUST00000368373.1 ENSMUSG00000141996 (from geneSymbol) uc338hjh.1 uc338hjh.1 
ENSMUST00000368374.1 ENSMUSG00000141997 ENSMUST00000368374.1 ENSMUSG00000141997 (from geneSymbol) uc338hji.1 uc338hji.1 
ENSMUST00000368375.1 A330049N07Rik ENSMUST00000368375.1 A330049N07Rik (from geneSymbol) AK039487 uc338hjj.1 uc338hjj.1 
ENSMUST00000368385.1 ENSMUSG00000141998 ENSMUST00000368385.1 ENSMUSG00000141998 (from geneSymbol) uc338hjt.1 uc338hjt.1 
ENSMUST00000368388.1 ENSMUSG00000141999 ENSMUST00000368388.1 ENSMUSG00000141999 (from geneSymbol) uc338hjw.1 uc338hjw.1 
ENSMUST00000368389.1 Gm16124 ENSMUST00000368389.1 Gm16124 (from geneSymbol) uc338hjx.1 uc338hjx.1 
ENSMUST00000368390.1 ENSMUSG00000142000 ENSMUST00000368390.1 ENSMUSG00000142000 (from geneSymbol) uc338hjy.1 uc338hjy.1 
ENSMUST00000368397.1 ENSMUSG00000142001 ENSMUST00000368397.1 ENSMUSG00000142001 (from geneSymbol) uc338hkf.1 uc338hkf.1 
ENSMUST00000368401.1 ENSMUSG00000142002 ENSMUST00000368401.1 ENSMUSG00000142002 (from geneSymbol) FJ541091 uc338hkj.1 uc338hkj.1 
ENSMUST00000368403.1 ENSMUSG00000142003 ENSMUST00000368403.1 ENSMUSG00000142003 (from geneSymbol) uc338hkl.1 uc338hkl.1 
ENSMUST00000368406.1 ENSMUSG00000142004 ENSMUST00000368406.1 ENSMUSG00000142004 (from geneSymbol) uc338hko.1 uc338hko.1 
ENSMUST00000368408.1 ENSMUSG00000142005 ENSMUST00000368408.1 ENSMUSG00000142005 (from geneSymbol) uc338hkq.1 uc338hkq.1 
ENSMUST00000368412.1 ENSMUSG00000142006 ENSMUST00000368412.1 ENSMUSG00000142006 (from geneSymbol) uc338hku.1 uc338hku.1 
ENSMUST00000368413.1 ENSMUSG00000142007 ENSMUST00000368413.1 ENSMUSG00000142007 (from geneSymbol) uc338hkv.1 uc338hkv.1 
ENSMUST00000368415.1 ENSMUSG00000142008 ENSMUST00000368415.1 ENSMUSG00000142008 (from geneSymbol) uc338hkx.1 uc338hkx.1 
ENSMUST00000368416.1 ENSMUSG00000142009 ENSMUST00000368416.1 ENSMUSG00000142009 (from geneSymbol) uc338hky.1 uc338hky.1 
ENSMUST00000368419.1 ENSMUSG00000142010 ENSMUST00000368419.1 ENSMUSG00000142010 (from geneSymbol) uc338hlb.1 uc338hlb.1 
ENSMUST00000368424.1 4930556C24Rik ENSMUST00000368424.1 4930556C24Rik (from geneSymbol) AK016142 uc338hlg.1 uc338hlg.1 
ENSMUST00000368427.1 ENSMUSG00000142011 ENSMUST00000368427.1 ENSMUSG00000142011 (from geneSymbol) uc338hlj.1 uc338hlj.1 
ENSMUST00000368428.1 ENSMUSG00000142012 ENSMUST00000368428.1 ENSMUSG00000142012 (from geneSymbol) uc338hlk.1 uc338hlk.1 
ENSMUST00000368429.1 ENSMUSG00000142013 ENSMUST00000368429.1 ENSMUSG00000142013 (from geneSymbol) uc338hll.1 uc338hll.1 
ENSMUST00000368448.1 ENSMUSG00000142014 ENSMUST00000368448.1 ENSMUSG00000142014 (from geneSymbol) uc338hme.1 uc338hme.1 
ENSMUST00000368449.1 ENSMUSG00000142015 ENSMUST00000368449.1 ENSMUSG00000142015 (from geneSymbol) uc338hmf.1 uc338hmf.1 
ENSMUST00000368450.1 ENSMUSG00000142016 ENSMUST00000368450.1 ENSMUSG00000142016 (from geneSymbol) uc338hmg.1 uc338hmg.1 
ENSMUST00000368452.1 ENSMUSG00000142017 ENSMUST00000368452.1 ENSMUSG00000142017 (from geneSymbol) uc338hmi.1 uc338hmi.1 
ENSMUST00000368453.1 ENSMUSG00000142018 ENSMUST00000368453.1 ENSMUSG00000142018 (from geneSymbol) uc338hmj.1 uc338hmj.1 
ENSMUST00000368454.1 ENSMUSG00000142019 ENSMUST00000368454.1 ENSMUSG00000142019 (from geneSymbol) uc338hmk.1 uc338hmk.1 
ENSMUST00000368455.1 ENSMUSG00000142020 ENSMUST00000368455.1 ENSMUSG00000142020 (from geneSymbol) uc338hml.1 uc338hml.1 
ENSMUST00000368470.1 ENSMUSG00000142021 ENSMUST00000368470.1 ENSMUSG00000142021 (from geneSymbol) uc338hna.1 uc338hna.1 
ENSMUST00000368471.1 ENSMUSG00000142022 ENSMUST00000368471.1 ENSMUSG00000142022 (from geneSymbol) uc338hnb.1 uc338hnb.1 
ENSMUST00000368472.1 ENSMUSG00000142023 ENSMUST00000368472.1 ENSMUSG00000142023 (from geneSymbol) AK013383 uc338hnc.1 uc338hnc.1 
ENSMUST00000368505.1 ENSMUSG00000142024 ENSMUST00000368505.1 ENSMUSG00000142024 (from geneSymbol) uc338hoi.1 uc338hoi.1 
ENSMUST00000368506.1 ENSMUSG00000142025 ENSMUST00000368506.1 ENSMUSG00000142025 (from geneSymbol) uc338hoj.1 uc338hoj.1 
ENSMUST00000368507.1 Gm57202 ENSMUST00000368507.1 Gm57202 (from geneSymbol) uc338hok.1 uc338hok.1 
ENSMUST00000368513.1 ENSMUSG00000142026 ENSMUST00000368513.1 ENSMUSG00000142026 (from geneSymbol) uc338hoq.1 uc338hoq.1 
ENSMUST00000368515.1 ENSMUSG00000142027 ENSMUST00000368515.1 ENSMUSG00000142027 (from geneSymbol) uc338hos.1 uc338hos.1 
ENSMUST00000368516.1 ENSMUSG00000142028 ENSMUST00000368516.1 ENSMUSG00000142028 (from geneSymbol) uc338hot.1 uc338hot.1 
ENSMUST00000368518.1 ENSMUSG00000142029 ENSMUST00000368518.1 ENSMUSG00000142029 (from geneSymbol) uc338hov.1 uc338hov.1 
ENSMUST00000368519.1 ENSMUSG00000142030 ENSMUST00000368519.1 ENSMUSG00000142030 (from geneSymbol) uc338how.1 uc338how.1 
ENSMUST00000368528.1 ENSMUSG00000142032 ENSMUST00000368528.1 ENSMUSG00000142032 (from geneSymbol) uc338hpe.1 uc338hpe.1 
ENSMUST00000368532.1 ENSMUSG00000142033 ENSMUST00000368532.1 predicted gene, 41259, transcript variant 1 (from RefSeq NR_155428.1) NR_155428 uc338hpi.1 uc338hpi.1 
ENSMUST00000368536.1 ENSMUSG00000142034 ENSMUST00000368536.1 ENSMUSG00000142034 (from geneSymbol) AK138145 uc338hpm.1 uc338hpm.1 
ENSMUST00000368537.1 Gm15938 ENSMUST00000368537.1 Gm15938 (from geneSymbol) AK021004 uc338hpn.1 uc338hpn.1 
ENSMUST00000368539.1 Gm26812 ENSMUST00000368539.1 Gm26812 (from geneSymbol) AK144755 uc338hpp.1 uc338hpp.1 
ENSMUST00000368553.1 Gm56493 ENSMUST00000368553.1 Gm56493 (from geneSymbol) uc338hqd.1 uc338hqd.1 
ENSMUST00000368560.1 ENSMUSG00000142035 ENSMUST00000368560.1 ENSMUSG00000142035 (from geneSymbol) uc338hqk.1 uc338hqk.1 
ENSMUST00000368569.1 ENSMUSG00000142036 ENSMUST00000368569.1 ENSMUSG00000142036 (from geneSymbol) uc338hqt.1 uc338hqt.1 
ENSMUST00000368570.1 Gm9989 ENSMUST00000368570.1 Gm9989 (from geneSymbol) uc338hqu.1 uc338hqu.1 
ENSMUST00000368612.1 ENSMUSG00000142037 ENSMUST00000368612.1 ENSMUSG00000142037 (from geneSymbol) uc338hsk.1 uc338hsk.1 
ENSMUST00000368613.1 ENSMUSG00000142038 ENSMUST00000368613.1 ENSMUSG00000142038 (from geneSymbol) uc338hsl.1 uc338hsl.1 
ENSMUST00000368614.1 ENSMUSG00000142039 ENSMUST00000368614.1 ENSMUSG00000142039 (from geneSymbol) uc338hsm.1 uc338hsm.1 
ENSMUST00000368615.1 ENSMUSG00000142040 ENSMUST00000368615.1 ENSMUSG00000142040 (from geneSymbol) uc338hsn.1 uc338hsn.1 
ENSMUST00000368627.1 ENSMUSG00000142041 ENSMUST00000368627.1 ENSMUSG00000142041 (from geneSymbol) uc338hsz.1 uc338hsz.1 
ENSMUST00000368628.1 ENSMUSG00000142042 ENSMUST00000368628.1 ENSMUSG00000142042 (from geneSymbol) BC080715 uc338hta.1 uc338hta.1 
ENSMUST00000368633.1 ENSMUSG00000142043 ENSMUST00000368633.1 ENSMUSG00000142043 (from geneSymbol) uc338htf.1 uc338htf.1 
ENSMUST00000368634.1 ENSMUSG00000142044 ENSMUST00000368634.1 ENSMUSG00000142044 (from geneSymbol) uc338htg.1 uc338htg.1 
ENSMUST00000368635.1 ENSMUSG00000142045 ENSMUST00000368635.1 ENSMUSG00000142045 (from geneSymbol) uc338hth.1 uc338hth.1 
ENSMUST00000368636.1 ENSMUSG00000142046 ENSMUST00000368636.1 ENSMUSG00000142046 (from geneSymbol) uc338hti.1 uc338hti.1 
ENSMUST00000368641.1 ENSMUSG00000142047 ENSMUST00000368641.1 ENSMUSG00000142047 (from geneSymbol) uc338htn.1 uc338htn.1 
ENSMUST00000368649.1 ENSMUSG00000142048 ENSMUST00000368649.1 ENSMUSG00000142048 (from geneSymbol) uc338htv.1 uc338htv.1 
ENSMUST00000368652.1 ENSMUSG00000142049 ENSMUST00000368652.1 ENSMUSG00000142049 (from geneSymbol) uc338hty.1 uc338hty.1 
ENSMUST00000368658.1 ENSMUSG00000142050 ENSMUST00000368658.1 ENSMUSG00000142050 (from geneSymbol) uc338hue.1 uc338hue.1 
ENSMUST00000368659.1 ENSMUSG00000142051 ENSMUST00000368659.1 ENSMUSG00000142051 (from geneSymbol) uc338huf.1 uc338huf.1 
ENSMUST00000368660.1 ENSMUSG00000142052 ENSMUST00000368660.1 ENSMUSG00000142052 (from geneSymbol) uc338hug.1 uc338hug.1 
ENSMUST00000368662.1 ENSMUSG00000142053 ENSMUST00000368662.1 ENSMUSG00000142053 (from geneSymbol) uc338hui.1 uc338hui.1 
ENSMUST00000368664.1 ENSMUSG00000142054 ENSMUST00000368664.1 ENSMUSG00000142054 (from geneSymbol) uc338huk.1 uc338huk.1 
ENSMUST00000368668.1 ENSMUSG00000142055 ENSMUST00000368668.1 ENSMUSG00000142055 (from geneSymbol) uc338huo.1 uc338huo.1 
ENSMUST00000368669.1 ENSMUSG00000142056 ENSMUST00000368669.1 ENSMUSG00000142056 (from geneSymbol) uc338hup.1 uc338hup.1 
ENSMUST00000368672.1 ENSMUSG00000142058 ENSMUST00000368672.1 ENSMUSG00000142058 (from geneSymbol) uc338hur.1 uc338hur.1 
ENSMUST00000368674.1 ENSMUSG00000142059 ENSMUST00000368674.1 ENSMUSG00000142059 (from geneSymbol) uc338hut.1 uc338hut.1 
ENSMUST00000368676.1 ENSMUSG00000142060 ENSMUST00000368676.1 ENSMUSG00000142060 (from geneSymbol) uc338huv.1 uc338huv.1 
ENSMUST00000368677.1 Gm2379 ENSMUST00000368677.1 Gm2379 (from geneSymbol) AK045784 uc338huw.1 uc338huw.1 
ENSMUST00000368686.1 ENSMUSG00000142061 ENSMUST00000368686.1 ENSMUSG00000142061 (from geneSymbol) uc338hvf.1 uc338hvf.1 
ENSMUST00000368728.1 ENSMUSG00000142062 ENSMUST00000368728.1 ENSMUSG00000142062 (from geneSymbol) uc338hwv.1 uc338hwv.1 
ENSMUST00000368730.1 ENSMUSG00000142063 ENSMUST00000368730.1 ENSMUSG00000142063 (from geneSymbol) uc338hwx.1 uc338hwx.1 
ENSMUST00000368731.1 ENSMUSG00000142064 ENSMUST00000368731.1 ENSMUSG00000142064 (from geneSymbol) uc338hwy.1 uc338hwy.1 
ENSMUST00000368732.1 ENSMUSG00000142065 ENSMUST00000368732.1 ENSMUSG00000142065 (from geneSymbol) uc338hwz.1 uc338hwz.1 
ENSMUST00000368733.1 ENSMUSG00000142066 ENSMUST00000368733.1 ENSMUSG00000142066 (from geneSymbol) uc338hxa.1 uc338hxa.1 
ENSMUST00000368735.1 ENSMUSG00000142067 ENSMUST00000368735.1 ENSMUSG00000142067 (from geneSymbol) LF198826 uc338hxc.1 uc338hxc.1 
ENSMUST00000368736.1 ENSMUSG00000142068 ENSMUST00000368736.1 ENSMUSG00000142068 (from geneSymbol) uc338hxd.1 uc338hxd.1 
ENSMUST00000368737.1 ENSMUSG00000142069 ENSMUST00000368737.1 ENSMUSG00000142069 (from geneSymbol) uc338hxe.1 uc338hxe.1 
ENSMUST00000368738.1 ENSMUSG00000142070 ENSMUST00000368738.1 ENSMUSG00000142070 (from geneSymbol) uc338hxf.1 uc338hxf.1 
ENSMUST00000368740.1 ENSMUSG00000142071 ENSMUST00000368740.1 ENSMUSG00000142071 (from geneSymbol) uc338hxh.1 uc338hxh.1 
ENSMUST00000368742.1 ENSMUSG00000142072 ENSMUST00000368742.1 ENSMUSG00000142072 (from geneSymbol) uc338hxj.1 uc338hxj.1 
ENSMUST00000368743.1 ENSMUSG00000142073 ENSMUST00000368743.1 ENSMUSG00000142073 (from geneSymbol) uc338hxk.1 uc338hxk.1 
ENSMUST00000368745.1 ENSMUSG00000142075 ENSMUST00000368745.1 ENSMUSG00000142075 (from geneSymbol) uc338hxl.1 uc338hxl.1 
ENSMUST00000368750.1 ENSMUSG00000142076 ENSMUST00000368750.1 ENSMUSG00000142076 (from geneSymbol) uc338hxq.1 uc338hxq.1 
ENSMUST00000368751.1 ENSMUSG00000142077 ENSMUST00000368751.1 ENSMUSG00000142077 (from geneSymbol) uc338hxr.1 uc338hxr.1 
ENSMUST00000368752.1 ENSMUSG00000142078 ENSMUST00000368752.1 ENSMUSG00000142078 (from geneSymbol) uc338hxs.1 uc338hxs.1 
ENSMUST00000368753.1 ENSMUSG00000142079 ENSMUST00000368753.1 ENSMUSG00000142079 (from geneSymbol) uc338hxt.1 uc338hxt.1 
ENSMUST00000368754.1 ENSMUSG00000142080 ENSMUST00000368754.1 ENSMUSG00000142080 (from geneSymbol) uc338hxu.1 uc338hxu.1 
ENSMUST00000368769.1 ENSMUSG00000142081 ENSMUST00000368769.1 ENSMUSG00000142081 (from geneSymbol) uc338hyj.1 uc338hyj.1 
ENSMUST00000368770.1 ENSMUSG00000142082 ENSMUST00000368770.1 ENSMUSG00000142082 (from geneSymbol) uc338hyk.1 uc338hyk.1 
ENSMUST00000368772.1 ENSMUSG00000142083 ENSMUST00000368772.1 ENSMUSG00000142083 (from geneSymbol) uc338hym.1 uc338hym.1 
ENSMUST00000368774.1 ENSMUSG00000142084 ENSMUST00000368774.1 ENSMUSG00000142084 (from geneSymbol) uc338hyo.1 uc338hyo.1 
ENSMUST00000368777.1 3830408C21Rik ENSMUST00000368777.1 3830408C21Rik (from geneSymbol) AK143700 uc338hyr.1 uc338hyr.1 
ENSMUST00000368872.1 ENSMUSG00000142085 ENSMUST00000368872.1 ENSMUSG00000142085 (from geneSymbol) uc338ici.1 uc338ici.1 
ENSMUST00000368878.1 ENSMUSG00000142086 ENSMUST00000368878.1 ENSMUSG00000142086 (from geneSymbol) uc338ico.1 uc338ico.1 
ENSMUST00000368882.1 ENSMUSG00000142087 ENSMUST00000368882.1 ENSMUSG00000142087 (from geneSymbol) uc338ics.1 uc338ics.1 
ENSMUST00000368883.1 ENSMUSG00000142088 ENSMUST00000368883.1 ENSMUSG00000142088 (from geneSymbol) uc338ict.1 uc338ict.1 
ENSMUST00000368884.1 ENSMUSG00000142089 ENSMUST00000368884.1 ENSMUSG00000142089 (from geneSymbol) uc338icu.1 uc338icu.1 
ENSMUST00000368885.1 ENSMUSG00000142090 ENSMUST00000368885.1 ENSMUSG00000142090 (from geneSymbol) uc338icv.1 uc338icv.1 
ENSMUST00000368886.1 ENSMUSG00000142091 ENSMUST00000368886.1 ENSMUSG00000142091 (from geneSymbol) uc338icw.1 uc338icw.1 
ENSMUST00000368887.1 ENSMUSG00000142092 ENSMUST00000368887.1 ENSMUSG00000142092 (from geneSymbol) uc338icx.1 uc338icx.1 
ENSMUST00000368891.1 ENSMUSG00000142093 ENSMUST00000368891.1 ENSMUSG00000142093 (from geneSymbol) uc338idb.1 uc338idb.1 
ENSMUST00000368892.1 ENSMUSG00000142094 ENSMUST00000368892.1 ENSMUSG00000142094 (from geneSymbol) uc338idc.1 uc338idc.1 
ENSMUST00000368893.1 ENSMUSG00000142095 ENSMUST00000368893.1 ENSMUSG00000142095 (from geneSymbol) uc338idd.1 uc338idd.1 
ENSMUST00000368894.1 ENSMUSG00000142096 ENSMUST00000368894.1 ENSMUSG00000142096 (from geneSymbol) uc338ide.1 uc338ide.1 
ENSMUST00000368896.1 ENSMUSG00000142097 ENSMUST00000368896.1 ENSMUSG00000142097 (from geneSymbol) uc338idg.1 uc338idg.1 
ENSMUST00000368898.1 Gm41625 ENSMUST00000368898.1 Gm41625 (from geneSymbol) uc338idi.1 uc338idi.1 
ENSMUST00000368907.1 ENSMUSG00000142098 ENSMUST00000368907.1 ENSMUSG00000142098 (from geneSymbol) EU234036 uc338idr.1 uc338idr.1 
ENSMUST00000368911.1 Gm5166 ENSMUST00000368911.1 Gm5166 (from geneSymbol) BC049655 uc338idv.1 uc338idv.1 
ENSMUST00000368921.1 ENSMUSG00000142100 ENSMUST00000368921.1 ENSMUSG00000142100 (from geneSymbol) uc338ief.1 uc338ief.1 
ENSMUST00000368928.1 4930578G10Rik ENSMUST00000368928.1 4930578G10Rik (from geneSymbol) AK006581 uc338iei.1 uc338iei.1 
ENSMUST00000368936.1 ENSMUSG00000142101 ENSMUST00000368936.1 ENSMUSG00000142101 (from geneSymbol) uc338ieq.1 uc338ieq.1 
ENSMUST00000369017.1 ENSMUSG00000144217 ENSMUST00000369017.1 ENSMUSG00000144217 (from geneSymbol) uc338ihp.1 uc338ihp.1 
ENSMUST00000369020.1 ENSMUSG00000144218 ENSMUST00000369020.1 ENSMUSG00000144218 (from geneSymbol) BC051472 uc338ihs.1 uc338ihs.1 
ENSMUST00000369050.1 ENSMUSG00000142102 ENSMUST00000369050.1 ENSMUSG00000142102 (from geneSymbol) uc338iiw.1 uc338iiw.1 
ENSMUST00000369053.1 ENSMUSG00000142103 ENSMUST00000369053.1 ENSMUSG00000142103 (from geneSymbol) uc338iiz.1 uc338iiz.1 
ENSMUST00000369059.1 ENSMUSG00000142104 ENSMUST00000369059.1 ENSMUSG00000142104 (from geneSymbol) uc338ijf.1 uc338ijf.1 
ENSMUST00000369060.1 ENSMUSG00000142105 ENSMUST00000369060.1 ENSMUSG00000142105 (from geneSymbol) uc338ijg.1 uc338ijg.1 
ENSMUST00000369061.1 ENSMUSG00000142106 ENSMUST00000369061.1 ENSMUSG00000142106 (from geneSymbol) uc338ijh.1 uc338ijh.1 
ENSMUST00000369068.1 ENSMUSG00000142107 ENSMUST00000369068.1 ENSMUSG00000142107 (from geneSymbol) uc338ijo.1 uc338ijo.1 
ENSMUST00000369070.1 ENSMUSG00000142108 ENSMUST00000369070.1 ENSMUSG00000142108 (from geneSymbol) uc338ijq.1 uc338ijq.1 
ENSMUST00000369072.1 ENSMUSG00000142109 ENSMUST00000369072.1 ENSMUSG00000142109 (from geneSymbol) uc338ijs.1 uc338ijs.1 
ENSMUST00000369075.1 ENSMUSG00000142110 ENSMUST00000369075.1 ENSMUSG00000142110 (from geneSymbol) uc338ijv.1 uc338ijv.1 
ENSMUST00000369079.1 ENSMUSG00000142111 ENSMUST00000369079.1 ENSMUSG00000142111 (from geneSymbol) uc338ijz.1 uc338ijz.1 
ENSMUST00000369080.1 Gm32872 ENSMUST00000369080.1 Gm32872 (from geneSymbol) uc338ika.1 uc338ika.1 
ENSMUST00000369087.1 Gm9898 ENSMUST00000369087.1 Gm9898 (from geneSymbol) uc338ikh.1 uc338ikh.1 
ENSMUST00000369098.1 ENSMUSG00000142112 ENSMUST00000369098.1 ENSMUSG00000142112 (from geneSymbol) EU234015 uc338iks.1 uc338iks.1 
ENSMUST00000369101.1 ENSMUSG00000142113 ENSMUST00000369101.1 ENSMUSG00000142113 (from geneSymbol) AK138696 uc338ikv.1 uc338ikv.1 
ENSMUST00000369102.1 Gm50418 ENSMUST00000369102.1 Gm50418 (from geneSymbol) uc338ikw.1 uc338ikw.1 
ENSMUST00000369107.1 ENSMUSG00000142114 ENSMUST00000369107.1 ENSMUSG00000142114 (from geneSymbol) uc338ilb.1 uc338ilb.1 
ENSMUST00000369108.1 ENSMUSG00000142115 ENSMUST00000369108.1 ENSMUSG00000142115 (from geneSymbol) uc338ilc.1 uc338ilc.1 
ENSMUST00000369110.1 ENSMUSG00000142117 ENSMUST00000369110.1 ENSMUSG00000142117 (from geneSymbol) uc338ild.1 uc338ild.1 
ENSMUST00000369113.1 ENSMUSG00000142118 ENSMUST00000369113.1 ENSMUSG00000142118 (from geneSymbol) uc338ilg.1 uc338ilg.1 
ENSMUST00000369115.1 ENSMUSG00000142119 ENSMUST00000369115.1 ENSMUSG00000142119 (from geneSymbol) uc338ili.1 uc338ili.1 
ENSMUST00000369117.1 ENSMUSG00000142120 ENSMUST00000369117.1 ENSMUSG00000142120 (from geneSymbol) uc338ilk.1 uc338ilk.1 
ENSMUST00000369118.1 ENSMUSG00000142121 ENSMUST00000369118.1 ENSMUSG00000142121 (from geneSymbol) uc338ill.1 uc338ill.1 
ENSMUST00000369120.1 ENSMUSG00000142122 ENSMUST00000369120.1 ENSMUSG00000142122 (from geneSymbol) uc338iln.1 uc338iln.1 
ENSMUST00000369123.1 Gm40264 ENSMUST00000369123.1 Gm40264 (from geneSymbol) uc338ilq.1 uc338ilq.1 
ENSMUST00000369135.1 ENSMUSG00000142123 ENSMUST00000369135.1 ENSMUSG00000142123 (from geneSymbol) uc338imc.1 uc338imc.1 
ENSMUST00000369137.1 ENSMUSG00000142124 ENSMUST00000369137.1 ENSMUSG00000142124 (from geneSymbol) uc338ime.1 uc338ime.1 
ENSMUST00000369140.1 ENSMUSG00000142125 ENSMUST00000369140.1 ENSMUSG00000142125 (from geneSymbol) uc338imh.1 uc338imh.1 
ENSMUST00000369141.1 ENSMUSG00000142126 ENSMUST00000369141.1 ENSMUSG00000142126 (from geneSymbol) uc338imi.1 uc338imi.1 
ENSMUST00000369146.1 Gm41392 ENSMUST00000369146.1 Gm41392 (from geneSymbol) uc338imn.1 uc338imn.1 
ENSMUST00000369149.1 ENSMUSG00000142127 ENSMUST00000369149.1 ENSMUSG00000142127 (from geneSymbol) AK012238 uc338imq.1 uc338imq.1 
ENSMUST00000369168.1 ENSMUSG00000142128 ENSMUST00000369168.1 ENSMUSG00000142128 (from geneSymbol) uc338inj.1 uc338inj.1 
ENSMUST00000369172.1 Gm20463 ENSMUST00000369172.1 Gm20463 (from geneSymbol) uc338inm.1 uc338inm.1 
ENSMUST00000369173.1 ENSMUSG00000142129 ENSMUST00000369173.1 ENSMUSG00000142129 (from geneSymbol) uc338inn.1 uc338inn.1 
ENSMUST00000369175.1 ENSMUSG00000121809 ENSMUST00000369175.1 ENSMUSG00000121809 (from geneSymbol) uc338inp.1 uc338inp.1 
ENSMUST00000369186.1 ENSMUSG00000142130 ENSMUST00000369186.1 ENSMUSG00000142130 (from geneSymbol) uc338ioa.1 uc338ioa.1 
ENSMUST00000369188.1 ENSMUSG00000142131 ENSMUST00000369188.1 ENSMUSG00000142131 (from geneSymbol) uc338ioc.1 uc338ioc.1 
ENSMUST00000369189.1 ENSMUSG00000142132 ENSMUST00000369189.1 ENSMUSG00000142132 (from geneSymbol) uc338iod.1 uc338iod.1 
ENSMUST00000369190.1 ENSMUSG00000142133 ENSMUST00000369190.1 ENSMUSG00000142133 (from geneSymbol) uc338ioe.1 uc338ioe.1 
ENSMUST00000369193.1 ENSMUSG00000142134 ENSMUST00000369193.1 ENSMUSG00000142134 (from geneSymbol) uc338ioh.1 uc338ioh.1 
ENSMUST00000369196.1 ENSMUSG00000142135 ENSMUST00000369196.1 ENSMUSG00000142135 (from geneSymbol) uc338iok.1 uc338iok.1 
ENSMUST00000369199.1 ENSMUSG00000142136 ENSMUST00000369199.1 ENSMUSG00000142136 (from geneSymbol) uc338ion.1 uc338ion.1 
ENSMUST00000369205.1 ENSMUSG00000142137 ENSMUST00000369205.1 ENSMUSG00000142137 (from geneSymbol) uc338iot.1 uc338iot.1 
ENSMUST00000369232.1 ENSMUSG00000142138 ENSMUST00000369232.1 ENSMUSG00000142138 (from geneSymbol) uc338ipu.1 uc338ipu.1 
ENSMUST00000369244.1 ENSMUSG00000142139 ENSMUST00000369244.1 ENSMUSG00000142139 (from geneSymbol) AK007112 uc338iqg.1 uc338iqg.1 
ENSMUST00000369249.1 Gm31410 ENSMUST00000369249.1 Gm31410 (from geneSymbol) AK076263 uc338iql.1 uc338iql.1 
ENSMUST00000369259.1 ENSMUSG00000142140 ENSMUST00000369259.1 ENSMUSG00000142140 (from geneSymbol) uc338iqv.1 uc338iqv.1 
ENSMUST00000369263.1 Gm12925 ENSMUST00000369263.1 Gm12925 (from geneSymbol) KY468016 uc338iqz.1 uc338iqz.1 
ENSMUST00000369267.1 ENSMUSG00000142141 ENSMUST00000369267.1 ENSMUSG00000142141 (from geneSymbol) uc338ird.1 uc338ird.1 
ENSMUST00000369268.1 ENSMUSG00000142142 ENSMUST00000369268.1 ENSMUSG00000142142 (from geneSymbol) uc338ire.1 uc338ire.1 
ENSMUST00000369269.1 ENSMUSG00000142143 ENSMUST00000369269.1 ENSMUSG00000142143 (from geneSymbol) uc338irf.1 uc338irf.1 
ENSMUST00000369272.1 ENSMUSG00000142144 ENSMUST00000369272.1 ENSMUSG00000142144 (from geneSymbol) uc338iri.1 uc338iri.1 
ENSMUST00000369274.1 ENSMUSG00000142145 ENSMUST00000369274.1 ENSMUSG00000142145 (from geneSymbol) uc338irj.1 uc338irj.1 
ENSMUST00000369275.1 ENSMUSG00000142146 ENSMUST00000369275.1 ENSMUSG00000142146 (from geneSymbol) uc338irk.1 uc338irk.1 
ENSMUST00000369277.1 ENSMUSG00000142147 ENSMUST00000369277.1 ENSMUSG00000142147 (from geneSymbol) uc338irm.1 uc338irm.1 
ENSMUST00000369317.1 ENSMUSG00000142148 ENSMUST00000369317.1 ENSMUSG00000142148 (from geneSymbol) BC089465 uc338ita.1 uc338ita.1 
ENSMUST00000369318.1 ENSMUSG00000142149 ENSMUST00000369318.1 ENSMUSG00000142149 (from geneSymbol) uc338itb.1 uc338itb.1 
ENSMUST00000369319.1 ENSMUSG00000142150 ENSMUST00000369319.1 ENSMUSG00000142150 (from geneSymbol) uc338itc.1 uc338itc.1 
ENSMUST00000369320.1 ENSMUSG00000142151 ENSMUST00000369320.1 ENSMUSG00000142151 (from geneSymbol) uc338itd.1 uc338itd.1 
ENSMUST00000369324.1 ENSMUSG00000142152 ENSMUST00000369324.1 ENSMUSG00000142152 (from geneSymbol) uc338ith.1 uc338ith.1 
ENSMUST00000369330.1 ENSMUSG00000142153 ENSMUST00000369330.1 ENSMUSG00000142153 (from geneSymbol) uc338itn.1 uc338itn.1 
ENSMUST00000369333.1 ENSMUSG00000142154 ENSMUST00000369333.1 ENSMUSG00000142154 (from geneSymbol) uc338itq.1 uc338itq.1 
ENSMUST00000369336.1 ENSMUSG00000142155 ENSMUST00000369336.1 ENSMUSG00000142155 (from geneSymbol) uc338itt.1 uc338itt.1 
ENSMUST00000369337.1 ENSMUSG00000142156 ENSMUST00000369337.1 ENSMUSG00000142156 (from geneSymbol) uc338itu.1 uc338itu.1 
ENSMUST00000369338.1 1700065L07Rik ENSMUST00000369338.1 1700065L07Rik (from geneSymbol) AK006896 uc338itv.1 uc338itv.1 
ENSMUST00000369353.1 ENSMUSG00000142157 ENSMUST00000369353.1 ENSMUSG00000142157 (from geneSymbol) uc338iui.1 uc338iui.1 
ENSMUST00000369357.1 ENSMUSG00000142158 ENSMUST00000369357.1 ENSMUSG00000142158 (from geneSymbol) uc338ium.1 uc338ium.1 
ENSMUST00000369361.1 ENSMUSG00000142159 ENSMUST00000369361.1 ENSMUSG00000142159 (from geneSymbol) uc338iuq.1 uc338iuq.1 
ENSMUST00000369362.1 ENSMUSG00000142160 ENSMUST00000369362.1 ENSMUSG00000142160 (from geneSymbol) uc338iur.1 uc338iur.1 
ENSMUST00000369364.1 ENSMUSG00000142161 ENSMUST00000369364.1 ENSMUSG00000142161 (from geneSymbol) uc338iut.1 uc338iut.1 
ENSMUST00000369368.1 ENSMUSG00000142162 ENSMUST00000369368.1 ENSMUSG00000142162 (from geneSymbol) uc338iux.1 uc338iux.1 
ENSMUST00000369369.1 ENSMUSG00000142163 ENSMUST00000369369.1 ENSMUSG00000142163 (from geneSymbol) uc338iuy.1 uc338iuy.1 
ENSMUST00000369371.1 ENSMUSG00000142164 ENSMUST00000369371.1 ENSMUSG00000142164 (from geneSymbol) uc338iva.1 uc338iva.1 
ENSMUST00000369372.1 4930477E14Rik ENSMUST00000369372.1 4930477E14Rik (from geneSymbol) uc338ivb.1 uc338ivb.1 
ENSMUST00000369377.1 ENSMUSG00000142165 ENSMUST00000369377.1 ENSMUSG00000142165 (from geneSymbol) LF198949 uc338ivg.1 uc338ivg.1 
ENSMUST00000369378.1 ENSMUSG00000142166 ENSMUST00000369378.1 ENSMUSG00000142166 (from geneSymbol) uc338ivh.1 uc338ivh.1 
ENSMUST00000369379.1 ENSMUSG00000142167 ENSMUST00000369379.1 ENSMUSG00000142167 (from geneSymbol) M55219 uc338ivi.1 uc338ivi.1 
ENSMUST00000369381.1 Gm41819 ENSMUST00000369381.1 Gm41819 (from geneSymbol) AK077070 uc338ivk.1 uc338ivk.1 
ENSMUST00000369398.1 ENSMUSG00000142168 ENSMUST00000369398.1 ENSMUSG00000142168 (from geneSymbol) uc338iwb.1 uc338iwb.1 
ENSMUST00000369399.1 ENSMUSG00000142169 ENSMUST00000369399.1 ENSMUSG00000142169 (from geneSymbol) uc338iwc.1 uc338iwc.1 
ENSMUST00000369434.1 2310047K21Rik ENSMUST00000369434.1 2310047K21Rik (from geneSymbol) uc338ixl.1 uc338ixl.1 
ENSMUST00000369438.1 ENSMUSG00000142170 ENSMUST00000369438.1 ENSMUSG00000142170 (from geneSymbol) uc338ixp.1 uc338ixp.1 
ENSMUST00000369440.1 ENSMUSG00000142171 ENSMUST00000369440.1 ENSMUSG00000142171 (from geneSymbol) uc338ixr.1 uc338ixr.1 
ENSMUST00000369441.1 Gm56771 ENSMUST00000369441.1 Gm56771 (from geneSymbol) uc338ixs.1 uc338ixs.1 
ENSMUST00000369461.1 2010001A14Rik ENSMUST00000369461.1 2010001A14Rik (from geneSymbol) AK007998 uc338iym.1 uc338iym.1 
ENSMUST00000369479.1 ENSMUSG00000142172 ENSMUST00000369479.1 ENSMUSG00000142172 (from geneSymbol) uc338ize.1 uc338ize.1 
ENSMUST00000369480.1 ENSMUSG00000142173 ENSMUST00000369480.1 ENSMUSG00000142173 (from geneSymbol) uc338izf.1 uc338izf.1 
ENSMUST00000369481.1 ENSMUSG00000142174 ENSMUST00000369481.1 ENSMUSG00000142174 (from geneSymbol) uc338izg.1 uc338izg.1 
ENSMUST00000369483.1 ENSMUSG00000142175 ENSMUST00000369483.1 ENSMUSG00000142175 (from geneSymbol) uc338izi.1 uc338izi.1 
ENSMUST00000369486.1 ENSMUSG00000142176 ENSMUST00000369486.1 ENSMUSG00000142176 (from geneSymbol) uc338izl.1 uc338izl.1 
ENSMUST00000369491.1 ENSMUSG00000142177 ENSMUST00000369491.1 ENSMUSG00000142177 (from geneSymbol) uc338izq.1 uc338izq.1 
ENSMUST00000369501.1 ENSMUSG00000142179 ENSMUST00000369501.1 ENSMUSG00000142179 (from geneSymbol) AK006494 uc338izx.1 uc338izx.1 
ENSMUST00000369502.1 ENSMUSG00000142180 ENSMUST00000369502.1 ENSMUSG00000142180 (from geneSymbol) uc338izy.1 uc338izy.1 
ENSMUST00000369503.1 ENSMUSG00000142181 ENSMUST00000369503.1 ENSMUSG00000142181 (from geneSymbol) uc338izz.1 uc338izz.1 
ENSMUST00000369504.1 ENSMUSG00000142182 ENSMUST00000369504.1 ENSMUSG00000142182 (from geneSymbol) uc338jaa.1 uc338jaa.1 
ENSMUST00000369509.1 ENSMUSG00000142183 ENSMUST00000369509.1 ENSMUSG00000142183 (from geneSymbol) uc338jaf.1 uc338jaf.1 
ENSMUST00000369510.1 ENSMUSG00000142184 ENSMUST00000369510.1 ENSMUSG00000142184 (from geneSymbol) uc338jag.1 uc338jag.1 
ENSMUST00000369514.1 ENSMUSG00000142185 ENSMUST00000369514.1 ENSMUSG00000142185 (from geneSymbol) uc338jak.1 uc338jak.1 
ENSMUST00000369515.1 ENSMUSG00000142186 ENSMUST00000369515.1 ENSMUSG00000142186 (from geneSymbol) uc338jal.1 uc338jal.1 
ENSMUST00000369516.1 ENSMUSG00000142187 ENSMUST00000369516.1 ENSMUSG00000142187 (from geneSymbol) uc338jam.1 uc338jam.1 
ENSMUST00000369518.1 ENSMUSG00000142188 ENSMUST00000369518.1 ENSMUSG00000142188 (from geneSymbol) uc338jao.1 uc338jao.1 
ENSMUST00000369521.1 ENSMUSG00000142189 ENSMUST00000369521.1 ENSMUSG00000142189 (from geneSymbol) uc338jar.1 uc338jar.1 
ENSMUST00000369525.1 Gm13307 ENSMUST00000369525.1 Gm13307 (from geneSymbol) BC025130 uc338jav.1 uc338jav.1 
ENSMUST00000369566.1 ENSMUSG00000142190 ENSMUST00000369566.1 ENSMUSG00000142190 (from geneSymbol) uc338jcj.1 uc338jcj.1 
ENSMUST00000369567.1 ENSMUSG00000142191 ENSMUST00000369567.1 ENSMUSG00000142191 (from geneSymbol) uc338jck.1 uc338jck.1 
ENSMUST00000369568.1 ENSMUSG00000142192 ENSMUST00000369568.1 ENSMUSG00000142192 (from geneSymbol) uc338jcl.1 uc338jcl.1 
ENSMUST00000369569.1 ENSMUSG00000142193 ENSMUST00000369569.1 ENSMUSG00000142193 (from geneSymbol) uc338jcm.1 uc338jcm.1 
ENSMUST00000369573.1 ENSMUSG00000142194 ENSMUST00000369573.1 ENSMUSG00000142194 (from geneSymbol) uc338jcq.1 uc338jcq.1 
ENSMUST00000369574.1 ENSMUSG00000142195 ENSMUST00000369574.1 ENSMUSG00000142195 (from geneSymbol) uc338jcr.1 uc338jcr.1 
ENSMUST00000369575.1 ENSMUSG00000142196 ENSMUST00000369575.1 ENSMUSG00000142196 (from geneSymbol) uc338jcs.1 uc338jcs.1 
ENSMUST00000369580.1 ENSMUSG00000142197 ENSMUST00000369580.1 ENSMUSG00000142197 (from geneSymbol) uc338jcx.1 uc338jcx.1 
ENSMUST00000369581.1 ENSMUSG00000142198 ENSMUST00000369581.1 ENSMUSG00000142198 (from geneSymbol) uc338jcy.1 uc338jcy.1 
ENSMUST00000369582.1 ENSMUSG00000142199 ENSMUST00000369582.1 ENSMUSG00000142199 (from geneSymbol) uc338jcz.1 uc338jcz.1 
ENSMUST00000369583.1 Gm47358 ENSMUST00000369583.1 Gm47358 (from geneSymbol) uc338jda.1 uc338jda.1 
ENSMUST00000369590.1 ENSMUSG00000142200 ENSMUST00000369590.1 ENSMUSG00000142200 (from geneSymbol) uc338jdh.1 uc338jdh.1 
ENSMUST00000369605.1 ENSMUSG00000142201 ENSMUST00000369605.1 ENSMUSG00000142201 (from geneSymbol) uc338jdw.1 uc338jdw.1 
ENSMUST00000369607.1 ENSMUSG00000142202 ENSMUST00000369607.1 ENSMUSG00000142202 (from geneSymbol) uc338jdy.1 uc338jdy.1 
ENSMUST00000369609.1 ENSMUSG00000142203 ENSMUST00000369609.1 ENSMUSG00000142203 (from geneSymbol) uc338jea.1 uc338jea.1 
ENSMUST00000369618.1 ENSMUSG00000142204 ENSMUST00000369618.1 ENSMUSG00000142204 (from geneSymbol) uc338jej.1 uc338jej.1 
ENSMUST00000369621.1 Gm26654 ENSMUST00000369621.1 Gm26654 (from geneSymbol) uc338jem.1 uc338jem.1 
ENSMUST00000369628.1 ENSMUSG00000142205 ENSMUST00000369628.1 ENSMUSG00000142205 (from geneSymbol) uc338jet.1 uc338jet.1 
ENSMUST00000369630.1 ENSMUSG00000142206 ENSMUST00000369630.1 ENSMUSG00000142206 (from geneSymbol) uc338jev.1 uc338jev.1 
ENSMUST00000369631.1 ENSMUSG00000142207 ENSMUST00000369631.1 ENSMUSG00000142207 (from geneSymbol) uc338jew.1 uc338jew.1 
ENSMUST00000369632.1 ENSMUSG00000142208 ENSMUST00000369632.1 ENSMUSG00000142208 (from geneSymbol) uc338jex.1 uc338jex.1 
ENSMUST00000369636.1 ENSMUSG00000142209 ENSMUST00000369636.1 ENSMUSG00000142209 (from geneSymbol) uc338jfb.1 uc338jfb.1 
ENSMUST00000369637.1 ENSMUSG00000142210 ENSMUST00000369637.1 ENSMUSG00000142210 (from geneSymbol) uc338jfc.1 uc338jfc.1 
ENSMUST00000369639.1 ENSMUSG00000142211 ENSMUST00000369639.1 ENSMUSG00000142211 (from geneSymbol) uc338jfe.1 uc338jfe.1 
ENSMUST00000369648.1 ENSMUSG00000142212 ENSMUST00000369648.1 ENSMUSG00000142212 (from geneSymbol) uc338jfn.1 uc338jfn.1 
ENSMUST00000369651.1 ENSMUSG00000142213 ENSMUST00000369651.1 ENSMUSG00000142213 (from geneSymbol) uc338jfq.1 uc338jfq.1 
ENSMUST00000369653.1 ENSMUSG00000142214 ENSMUST00000369653.1 ENSMUSG00000142214 (from geneSymbol) uc338jfs.1 uc338jfs.1 
ENSMUST00000369654.1 ENSMUSG00000142215 ENSMUST00000369654.1 ENSMUSG00000142215 (from geneSymbol) uc338jft.1 uc338jft.1 
ENSMUST00000369655.1 ENSMUSG00000142216 ENSMUST00000369655.1 ENSMUSG00000142216 (from geneSymbol) uc338jfu.1 uc338jfu.1 
ENSMUST00000369656.1 ENSMUSG00000142217 ENSMUST00000369656.1 ENSMUSG00000142217 (from geneSymbol) uc338jfv.1 uc338jfv.1 
ENSMUST00000369663.1 ENSMUSG00000142218 ENSMUST00000369663.1 ENSMUSG00000142218 (from geneSymbol) uc338jgc.1 uc338jgc.1 
ENSMUST00000369664.1 ENSMUSG00000142219 ENSMUST00000369664.1 ENSMUSG00000142219 (from geneSymbol) AK042183 uc338jgd.1 uc338jgd.1 
ENSMUST00000369665.1 ENSMUSG00000142220 ENSMUST00000369665.1 ENSMUSG00000142220 (from geneSymbol) uc338jge.1 uc338jge.1 
ENSMUST00000369666.1 Gm56717 ENSMUST00000369666.1 Gm56717 (from geneSymbol) uc338jgf.1 uc338jgf.1 
ENSMUST00000369687.1 ENSMUSG00000142221 ENSMUST00000369687.1 ENSMUSG00000142221 (from geneSymbol) uc338jha.1 uc338jha.1 
ENSMUST00000369692.1 ENSMUSG00000142222 ENSMUST00000369692.1 ENSMUSG00000142222 (from geneSymbol) uc338jhf.1 uc338jhf.1 
ENSMUST00000369695.1 Gm4668 ENSMUST00000369695.1 Gm4668 (from geneSymbol) AK041339 uc338jhi.1 uc338jhi.1 
ENSMUST00000369704.1 ENSMUSG00000142223 ENSMUST00000369704.1 ENSMUSG00000142223 (from geneSymbol) uc338jhr.1 uc338jhr.1 
ENSMUST00000369706.1 ENSMUSG00000142224 ENSMUST00000369706.1 ENSMUSG00000142224 (from geneSymbol) uc338jht.1 uc338jht.1 
ENSMUST00000369711.1 Gm4832 ENSMUST00000369711.1 Gm4832 (from geneSymbol) AK139504 uc338jhw.1 uc338jhw.1 
ENSMUST00000369730.1 Gm29208 ENSMUST00000369730.1 Gm29208 (from geneSymbol) uc338jip.1 uc338jip.1 
ENSMUST00000369736.1 ENSMUSG00000142225 ENSMUST00000369736.1 ENSMUSG00000142225 (from geneSymbol) uc338jiv.1 uc338jiv.1 
ENSMUST00000369739.1 ENSMUSG00000142226 ENSMUST00000369739.1 ENSMUSG00000142226 (from geneSymbol) uc338jiy.1 uc338jiy.1 
ENSMUST00000369740.1 ENSMUSG00000142227 ENSMUST00000369740.1 ENSMUSG00000142227 (from geneSymbol) uc338jiz.1 uc338jiz.1 
ENSMUST00000369741.1 ENSMUSG00000142228 ENSMUST00000369741.1 ENSMUSG00000142228 (from geneSymbol) uc338jja.1 uc338jja.1 
ENSMUST00000369742.1 ENSMUSG00000142229 ENSMUST00000369742.1 ENSMUSG00000142229 (from geneSymbol) uc338jjb.1 uc338jjb.1 
ENSMUST00000369744.1 ENSMUSG00000142230 ENSMUST00000369744.1 ENSMUSG00000142230 (from geneSymbol) uc338jjd.1 uc338jjd.1 
ENSMUST00000369745.1 ENSMUSG00000142231 ENSMUST00000369745.1 ENSMUSG00000142231 (from geneSymbol) uc338jje.1 uc338jje.1 
ENSMUST00000369748.1 Ccl19-ps1 ENSMUST00000369748.1 Ccl19-ps1 (from geneSymbol) uc338jjf.1 uc338jjf.1 
ENSMUST00000369763.1 ENSMUSG00000142233 ENSMUST00000369763.1 ENSMUSG00000142233 (from geneSymbol) uc338jjt.1 uc338jjt.1 
ENSMUST00000369764.1 ENSMUSG00000142234 ENSMUST00000369764.1 ENSMUSG00000142234 (from geneSymbol) uc338jju.1 uc338jju.1 
ENSMUST00000369767.1 ENSMUSG00000142235 ENSMUST00000369767.1 ENSMUSG00000142235 (from geneSymbol) uc338jjx.1 uc338jjx.1 
ENSMUST00000369768.1 ENSMUSG00000142236 ENSMUST00000369768.1 ENSMUSG00000142236 (from geneSymbol) uc338jjy.1 uc338jjy.1 
ENSMUST00000369769.1 ENSMUSG00000142237 ENSMUST00000369769.1 ENSMUSG00000142237 (from geneSymbol) uc338jjz.1 uc338jjz.1 
ENSMUST00000369770.1 ENSMUSG00000142238 ENSMUST00000369770.1 ENSMUSG00000142238 (from geneSymbol) uc338jka.1 uc338jka.1 
ENSMUST00000369772.1 ENSMUSG00000142239 ENSMUST00000369772.1 ENSMUSG00000142239 (from geneSymbol) uc338jkc.1 uc338jkc.1 
ENSMUST00000369774.1 ENSMUSG00000142240 ENSMUST00000369774.1 ENSMUSG00000142240 (from geneSymbol) uc338jke.1 uc338jke.1 
ENSMUST00000369777.1 ENSMUSG00000142241 ENSMUST00000369777.1 ENSMUSG00000142241 (from geneSymbol) uc338jkh.1 uc338jkh.1 
ENSMUST00000369787.1 ENSMUSG00000142242 ENSMUST00000369787.1 ENSMUSG00000142242 (from geneSymbol) uc338jkr.1 uc338jkr.1 
ENSMUST00000369790.1 ENSMUSG00000142244 ENSMUST00000369790.1 ENSMUSG00000142244 (from geneSymbol) uc338jks.1 uc338jks.1 
ENSMUST00000369798.1 Kcnd3os ENSMUST00000369798.1 Kcnd3os (from geneSymbol) AK018929 uc338jla.1 uc338jla.1 
ENSMUST00000369817.1 ENSMUSG00000142245 ENSMUST00000369817.1 ENSMUSG00000142245 (from geneSymbol) uc338jlt.1 uc338jlt.1 
ENSMUST00000369818.1 ENSMUSG00000142246 ENSMUST00000369818.1 ENSMUSG00000142246 (from geneSymbol) uc338jlu.1 uc338jlu.1 
ENSMUST00000369821.1 ENSMUSG00000142247 ENSMUST00000369821.1 ENSMUSG00000142247 (from geneSymbol) uc338jlx.1 uc338jlx.1 
ENSMUST00000369823.1 ENSMUSG00000142248 ENSMUST00000369823.1 ENSMUSG00000142248 (from geneSymbol) uc338jlz.1 uc338jlz.1 
ENSMUST00000369824.1 ENSMUSG00000142249 ENSMUST00000369824.1 ENSMUSG00000142249 (from geneSymbol) uc338jma.1 uc338jma.1 
ENSMUST00000369825.1 ENSMUSG00000142250 ENSMUST00000369825.1 ENSMUSG00000142250 (from geneSymbol) uc338jmb.1 uc338jmb.1 
ENSMUST00000369826.1 ENSMUSG00000142251 ENSMUST00000369826.1 ENSMUSG00000142251 (from geneSymbol) uc338jmc.1 uc338jmc.1 
ENSMUST00000369827.1 ENSMUSG00000142252 ENSMUST00000369827.1 ENSMUSG00000142252 (from geneSymbol) uc338jmd.1 uc338jmd.1 
ENSMUST00000369829.1 ENSMUSG00000142253 ENSMUST00000369829.1 ENSMUSG00000142253 (from geneSymbol) uc338jmf.1 uc338jmf.1 
ENSMUST00000369830.1 ENSMUSG00000142254 ENSMUST00000369830.1 ENSMUSG00000142254 (from geneSymbol) uc338jmg.1 uc338jmg.1 
ENSMUST00000369831.1 ENSMUSG00000142255 ENSMUST00000369831.1 ENSMUSG00000142255 (from geneSymbol) uc338jmh.1 uc338jmh.1 
ENSMUST00000369833.1 ENSMUSG00000142256 ENSMUST00000369833.1 ENSMUSG00000142256 (from geneSymbol) uc338jmj.1 uc338jmj.1 
ENSMUST00000369838.1 ENSMUSG00000142257 ENSMUST00000369838.1 ENSMUSG00000142257 (from geneSymbol) uc338jmo.1 uc338jmo.1 
ENSMUST00000369851.1 ENSMUSG00000142258 ENSMUST00000369851.1 ENSMUSG00000142258 (from geneSymbol) uc338jnb.1 uc338jnb.1 
ENSMUST00000369852.1 ENSMUSG00000142259 ENSMUST00000369852.1 ENSMUSG00000142259 (from geneSymbol) uc338jnc.1 uc338jnc.1 
ENSMUST00000369853.1 ENSMUSG00000142260 ENSMUST00000369853.1 ENSMUSG00000142260 (from geneSymbol) uc338jnd.1 uc338jnd.1 
ENSMUST00000369854.1 ENSMUSG00000142261 ENSMUST00000369854.1 ENSMUSG00000142261 (from geneSymbol) uc338jne.1 uc338jne.1 
ENSMUST00000369857.1 Gm48199 ENSMUST00000369857.1 Gm48199 (from geneSymbol) uc338jnh.1 uc338jnh.1 
ENSMUST00000369891.1 Gm11528 ENSMUST00000369891.1 Gm11528 (from geneSymbol) uc338jop.1 uc338jop.1 
ENSMUST00000369893.1 ENSMUSG00000142262 ENSMUST00000369893.1 ENSMUSG00000142262 (from geneSymbol) uc338jor.1 uc338jor.1 
ENSMUST00000369898.1 4930453H23Rik ENSMUST00000369898.1 4930453H23Rik (from geneSymbol) AK015451 uc338jow.1 uc338jow.1 
ENSMUST00000369905.1 Gm57329 ENSMUST00000369905.1 Gm57329 (from geneSymbol) uc338jpd.1 uc338jpd.1 
ENSMUST00000369933.1 ENSMUSG00000142263 ENSMUST00000369933.1 ENSMUSG00000142263 (from geneSymbol) uc338jqf.1 uc338jqf.1 
ENSMUST00000369934.1 ENSMUSG00000142264 ENSMUST00000369934.1 ENSMUSG00000142264 (from geneSymbol) uc338jqg.1 uc338jqg.1 
ENSMUST00000369935.1 ENSMUSG00000142265 ENSMUST00000369935.1 ENSMUSG00000142265 (from geneSymbol) uc338jqh.1 uc338jqh.1 
ENSMUST00000369940.1 ENSMUSG00000142266 ENSMUST00000369940.1 ENSMUSG00000142266 (from geneSymbol) uc338jqm.1 uc338jqm.1 
ENSMUST00000369946.1 ENSMUSG00000142267 ENSMUST00000369946.1 ENSMUSG00000142267 (from geneSymbol) uc338jqs.1 uc338jqs.1 
ENSMUST00000369947.1 ENSMUSG00000142268 ENSMUST00000369947.1 ENSMUSG00000142268 (from geneSymbol) uc338jqt.1 uc338jqt.1 
ENSMUST00000369952.1 ENSMUSG00000142269 ENSMUST00000369952.1 ENSMUSG00000142269 (from geneSymbol) uc338jqy.1 uc338jqy.1 
ENSMUST00000369956.1 ENSMUSG00000142270 ENSMUST00000369956.1 ENSMUSG00000142270 (from geneSymbol) uc338jrc.1 uc338jrc.1 
ENSMUST00000369964.1 ENSMUSG00000142271 ENSMUST00000369964.1 ENSMUSG00000142271 (from geneSymbol) uc338jrk.1 uc338jrk.1 
ENSMUST00000369966.1 ENSMUSG00000142272 ENSMUST00000369966.1 ENSMUSG00000142272 (from geneSymbol) AK047639 uc338jrm.1 uc338jrm.1 
ENSMUST00000369987.1 ENSMUSG00000142273 ENSMUST00000369987.1 ENSMUSG00000142273 (from geneSymbol) uc338jsh.1 uc338jsh.1 
ENSMUST00000369988.1 4931407E12Rik ENSMUST00000369988.1 4931407E12Rik (from geneSymbol) AK016440 uc338jsi.1 uc338jsi.1 
ENSMUST00000369991.1 ENSMUSG00000142274 ENSMUST00000369991.1 ENSMUSG00000142274 (from geneSymbol) uc338jsl.1 uc338jsl.1 
ENSMUST00000369998.1 Gm13299 ENSMUST00000369998.1 Gm13299 (from geneSymbol) uc338jss.1 uc338jss.1 
ENSMUST00000370025.1 ENSMUSG00000142275 ENSMUST00000370025.1 ENSMUSG00000142275 (from geneSymbol) uc338jtt.1 uc338jtt.1 
ENSMUST00000370027.1 ENSMUSG00000142276 ENSMUST00000370027.1 ENSMUSG00000142276 (from geneSymbol) uc338jtv.1 uc338jtv.1 
ENSMUST00000370028.1 ENSMUSG00000142277 ENSMUST00000370028.1 ENSMUSG00000142277 (from geneSymbol) uc338jtw.1 uc338jtw.1 
ENSMUST00000370034.1 ENSMUSG00000142278 ENSMUST00000370034.1 ENSMUSG00000142278 (from geneSymbol) uc338juc.1 uc338juc.1 
ENSMUST00000370036.1 ENSMUSG00000142279 ENSMUST00000370036.1 ENSMUSG00000142279 (from geneSymbol) uc338jue.1 uc338jue.1 
ENSMUST00000370045.1 ENSMUSG00000142280 ENSMUST00000370045.1 ENSMUSG00000142280 (from geneSymbol) uc338jun.1 uc338jun.1 
ENSMUST00000370046.1 ENSMUSG00000142281 ENSMUST00000370046.1 ENSMUSG00000142281 (from geneSymbol) uc338juo.1 uc338juo.1 
ENSMUST00000370060.1 ENSMUSG00000142282 ENSMUST00000370060.1 ENSMUSG00000142282 (from geneSymbol) uc338jvc.1 uc338jvc.1 
ENSMUST00000370062.1 ENSMUSG00000142283 ENSMUST00000370062.1 ENSMUSG00000142283 (from geneSymbol) uc338jve.1 uc338jve.1 
ENSMUST00000370063.1 ENSMUSG00000142284 ENSMUST00000370063.1 ENSMUSG00000142284 (from geneSymbol) uc338jvf.1 uc338jvf.1 
ENSMUST00000370065.1 ENSMUSG00000142285 ENSMUST00000370065.1 ENSMUSG00000142285 (from geneSymbol) uc338jvh.1 uc338jvh.1 
ENSMUST00000370068.1 ENSMUSG00000142286 ENSMUST00000370068.1 ENSMUSG00000142286 (from geneSymbol) uc338jvk.1 uc338jvk.1 
ENSMUST00000370070.1 ENSMUSG00000142287 ENSMUST00000370070.1 ENSMUSG00000142287 (from geneSymbol) uc338jvm.1 uc338jvm.1 
ENSMUST00000370071.1 Gm30676 ENSMUST00000370071.1 Gm30676 (from geneSymbol) uc338jvn.1 uc338jvn.1 
ENSMUST00000370093.1 4930405L22Rik ENSMUST00000370093.1 4930405L22Rik (from geneSymbol) AK019567 uc338jwj.1 uc338jwj.1 
ENSMUST00000370096.1 ENSMUSG00000142288 ENSMUST00000370096.1 ENSMUSG00000142288 (from geneSymbol) uc338jwm.1 uc338jwm.1 
ENSMUST00000370097.1 ENSMUSG00000142289 ENSMUST00000370097.1 ENSMUSG00000142289 (from geneSymbol) uc338jwn.1 uc338jwn.1 
ENSMUST00000370098.1 ENSMUSG00000142290 ENSMUST00000370098.1 ENSMUSG00000142290 (from geneSymbol) AK050877 uc338jwo.1 uc338jwo.1 
ENSMUST00000370100.1 ENSMUSG00000142291 ENSMUST00000370100.1 ENSMUSG00000142291 (from geneSymbol) uc338jwq.1 uc338jwq.1 
ENSMUST00000370109.1 ENSMUSG00000142292 ENSMUST00000370109.1 ENSMUSG00000142292 (from geneSymbol) uc338jwz.1 uc338jwz.1 
ENSMUST00000370111.1 1700094J05Rik ENSMUST00000370111.1 1700094J05Rik (from geneSymbol) AK007067 uc338jxb.1 uc338jxb.1 
ENSMUST00000370123.1 Gm5947 ENSMUST00000370123.1 Gm5947 (from geneSymbol) uc338jxn.1 uc338jxn.1 
ENSMUST00000370125.1 ENSMUSG00000142294 ENSMUST00000370125.1 ENSMUSG00000142294 (from geneSymbol) uc338jxp.1 uc338jxp.1 
ENSMUST00000370127.1 Gm43468 ENSMUST00000370127.1 Gm43468 (from geneSymbol) uc338jxr.1 uc338jxr.1 
ENSMUST00000370131.1 ENSMUSG00000142295 ENSMUST00000370131.1 ENSMUSG00000142295 (from geneSymbol) uc338jxv.1 uc338jxv.1 
ENSMUST00000370139.1 Halr1 ENSMUST00000370139.1 Halr1 (from geneSymbol) uc338jyd.1 uc338jyd.1 
ENSMUST00000370172.1 4930405D11Rik ENSMUST00000370172.1 4930405D11Rik (from geneSymbol) AK015094 uc338jzk.1 uc338jzk.1 
ENSMUST00000370193.1 ENSMUSG00000142296 ENSMUST00000370193.1 ENSMUSG00000142296 (from geneSymbol) uc338kaf.1 uc338kaf.1 
ENSMUST00000370195.1 ENSMUSG00000142297 ENSMUST00000370195.1 ENSMUSG00000142297 (from geneSymbol) uc338kah.1 uc338kah.1 
ENSMUST00000370196.1 ENSMUSG00000142298 ENSMUST00000370196.1 ENSMUSG00000142298 (from geneSymbol) uc338kai.1 uc338kai.1 
ENSMUST00000370201.1 ENSMUSG00000142299 ENSMUST00000370201.1 ENSMUSG00000142299 (from geneSymbol) uc338kan.1 uc338kan.1 
ENSMUST00000370211.1 ENSMUSG00000142300 ENSMUST00000370211.1 ENSMUSG00000142300 (from geneSymbol) uc338kax.1 uc338kax.1 
ENSMUST00000370213.1 ENSMUSG00000142301 ENSMUST00000370213.1 ENSMUSG00000142301 (from geneSymbol) uc338kaz.1 uc338kaz.1 
ENSMUST00000370219.1 Gm48038 ENSMUST00000370219.1 Gm48038 (from geneSymbol) uc338kbf.1 uc338kbf.1 
ENSMUST00000370223.1 ENSMUSG00000142303 ENSMUST00000370223.1 ENSMUSG00000142303 (from geneSymbol) uc338kbi.1 uc338kbi.1 
ENSMUST00000370229.1 ENSMUSG00000142305 ENSMUST00000370229.1 ENSMUSG00000142305 (from geneSymbol) uc338kbk.1 uc338kbk.1 
ENSMUST00000370230.1 ENSMUSG00000142306 ENSMUST00000370230.1 ENSMUSG00000142306 (from geneSymbol) uc338kbl.1 uc338kbl.1 
ENSMUST00000370239.1 ENSMUSG00000142307 ENSMUST00000370239.1 ENSMUSG00000142307 (from geneSymbol) uc338kbu.1 uc338kbu.1 
ENSMUST00000370245.1 Gm7568 ENSMUST00000370245.1 Gm7568 (from geneSymbol) uc338kca.1 uc338kca.1 
ENSMUST00000370257.1 ENSMUSG00000142308 ENSMUST00000370257.1 ENSMUSG00000142308 (from geneSymbol) uc338kcm.1 uc338kcm.1 
ENSMUST00000370258.1 ENSMUSG00000142309 ENSMUST00000370258.1 ENSMUSG00000142309 (from geneSymbol) uc338kcn.1 uc338kcn.1 
ENSMUST00000370259.1 ENSMUSG00000142310 ENSMUST00000370259.1 ENSMUSG00000142310 (from geneSymbol) uc338kco.1 uc338kco.1 
ENSMUST00000370260.1 ENSMUSG00000142311 ENSMUST00000370260.1 ENSMUSG00000142311 (from geneSymbol) uc338kcp.1 uc338kcp.1 
ENSMUST00000370262.1 ENSMUSG00000142312 ENSMUST00000370262.1 ENSMUSG00000142312 (from geneSymbol) uc338kcr.1 uc338kcr.1 
ENSMUST00000370264.1 ENSMUSG00000142313 ENSMUST00000370264.1 ENSMUSG00000142313 (from geneSymbol) uc338kct.1 uc338kct.1 
ENSMUST00000370265.1 ENSMUSG00000142314 ENSMUST00000370265.1 ENSMUSG00000142314 (from geneSymbol) uc338kcu.1 uc338kcu.1 
ENSMUST00000370275.1 ENSMUSG00000142315 ENSMUST00000370275.1 ENSMUSG00000142315 (from geneSymbol) uc338kde.1 uc338kde.1 
ENSMUST00000370292.1 Gm4827 ENSMUST00000370292.1 Gm4827 (from geneSymbol) AK045242 uc338kdv.1 uc338kdv.1 
ENSMUST00000370321.1 ENSMUSG00000142316 ENSMUST00000370321.1 ENSMUSG00000142316 (from geneSymbol) uc338key.1 uc338key.1 
ENSMUST00000370322.1 ENSMUSG00000142317 ENSMUST00000370322.1 ENSMUSG00000142317 (from geneSymbol) uc338kez.1 uc338kez.1 
ENSMUST00000370325.1 ENSMUSG00000142318 ENSMUST00000370325.1 ENSMUSG00000142318 (from geneSymbol) uc338kfc.1 uc338kfc.1 
ENSMUST00000370329.1 Ccl19-ps2 ENSMUST00000370329.1 Ccl19-ps2 (from geneSymbol) uc338kfg.1 uc338kfg.1 
ENSMUST00000370355.1 ENSMUSG00000142320 ENSMUST00000370355.1 ENSMUSG00000142320 (from geneSymbol) uc338kgg.1 uc338kgg.1 
ENSMUST00000370356.1 ENSMUSG00000142321 ENSMUST00000370356.1 ENSMUSG00000142321 (from geneSymbol) FJ541078 uc338kgh.1 uc338kgh.1 
ENSMUST00000370363.1 ENSMUSG00000142322 ENSMUST00000370363.1 ENSMUSG00000142322 (from geneSymbol) uc338kgo.1 uc338kgo.1 
ENSMUST00000370368.1 ENSMUSG00000142324 ENSMUST00000370368.1 ENSMUSG00000142324 (from geneSymbol) uc338kgs.1 uc338kgs.1 
ENSMUST00000370369.1 ENSMUSG00000142325 ENSMUST00000370369.1 ENSMUSG00000142325 (from geneSymbol) uc338kgt.1 uc338kgt.1 
ENSMUST00000370380.1 ENSMUSG00000142326 ENSMUST00000370380.1 ENSMUSG00000142326 (from geneSymbol) uc338khe.1 uc338khe.1 
ENSMUST00000370384.1 ENSMUSG00000142327 ENSMUST00000370384.1 ENSMUSG00000142327 (from geneSymbol) uc338khi.1 uc338khi.1 
ENSMUST00000370386.1 ENSMUSG00000142328 ENSMUST00000370386.1 ENSMUSG00000142328 (from geneSymbol) uc338khk.1 uc338khk.1 
ENSMUST00000370388.1 ENSMUSG00000142329 ENSMUST00000370388.1 ENSMUSG00000142329 (from geneSymbol) uc338khm.1 uc338khm.1 
ENSMUST00000370391.1 Gm56760 ENSMUST00000370391.1 Gm56760 (from geneSymbol) uc338khp.1 uc338khp.1 
ENSMUST00000370406.1 ENSMUSG00000142330 ENSMUST00000370406.1 ENSMUSG00000142330 (from geneSymbol) uc338kie.1 uc338kie.1 
ENSMUST00000370408.1 ENSMUSG00000142331 ENSMUST00000370408.1 ENSMUSG00000142331 (from geneSymbol) uc338kig.1 uc338kig.1 
ENSMUST00000370409.1 ENSMUSG00000142332 ENSMUST00000370409.1 ENSMUSG00000142332 (from geneSymbol) uc338kih.1 uc338kih.1 
ENSMUST00000370421.1 ENSMUSG00000142334 ENSMUST00000370421.1 ENSMUSG00000142334 (from geneSymbol) uc338kis.1 uc338kis.1 
ENSMUST00000370423.1 4930479D17Rik ENSMUST00000370423.1 4930479D17Rik (from geneSymbol) AK015591 uc338kiu.1 uc338kiu.1 
ENSMUST00000370425.1 Gm12130 ENSMUST00000370425.1 Gm12130 (from geneSymbol) AK145334 uc338kiw.1 uc338kiw.1 
ENSMUST00000370428.1 ENSMUSG00000142335 ENSMUST00000370428.1 ENSMUSG00000142335 (from geneSymbol) uc338kiz.1 uc338kiz.1 
ENSMUST00000370434.1 Gm48284 ENSMUST00000370434.1 Gm48284 (from geneSymbol) uc338kjf.1 uc338kjf.1 
ENSMUST00000370441.1 ENSMUSG00000142336 ENSMUST00000370441.1 ENSMUSG00000142336 (from geneSymbol) uc338kjm.1 uc338kjm.1 
ENSMUST00000370442.1 ENSMUSG00000142337 ENSMUST00000370442.1 ENSMUSG00000142337 (from geneSymbol) uc338kjn.1 uc338kjn.1 
ENSMUST00000370445.1 ENSMUSG00000142338 ENSMUST00000370445.1 ENSMUSG00000142338 (from geneSymbol) uc338kjq.1 uc338kjq.1 
ENSMUST00000370455.1 ENSMUSG00000142339 ENSMUST00000370455.1 ENSMUSG00000142339 (from geneSymbol) uc338kka.1 uc338kka.1 
ENSMUST00000370468.1 ENSMUSG00000142340 ENSMUST00000370468.1 ENSMUSG00000142340 (from geneSymbol) uc338kkn.1 uc338kkn.1 
ENSMUST00000370469.1 ENSMUSG00000142341 ENSMUST00000370469.1 ENSMUSG00000142341 (from geneSymbol) uc338kko.1 uc338kko.1 
ENSMUST00000370483.1 ENSMUSG00000142342 ENSMUST00000370483.1 ENSMUSG00000142342 (from geneSymbol) uc338klc.1 uc338klc.1 
ENSMUST00000370484.1 1700039M15Rik ENSMUST00000370484.1 1700039M15Rik (from geneSymbol) AK006645 uc338kld.1 uc338kld.1 
ENSMUST00000370485.1 ENSMUSG00000142343 ENSMUST00000370485.1 ENSMUSG00000142343 (from geneSymbol) uc338kle.1 uc338kle.1 
ENSMUST00000370486.1 ENSMUSG00000142344 ENSMUST00000370486.1 ENSMUSG00000142344 (from geneSymbol) uc338klf.1 uc338klf.1 
ENSMUST00000370487.1 4933405E24Rik ENSMUST00000370487.1 4933405E24Rik (from geneSymbol) AK016664 uc338klg.1 uc338klg.1 
ENSMUST00000370496.1 ENSMUSG00000142345 ENSMUST00000370496.1 ENSMUSG00000142345 (from geneSymbol) uc338klp.1 uc338klp.1 
ENSMUST00000370504.1 ENSMUSG00000142346 ENSMUST00000370504.1 ENSMUSG00000142346 (from geneSymbol) uc338klw.1 uc338klw.1 
ENSMUST00000370505.1 ENSMUSG00000142347 ENSMUST00000370505.1 ENSMUSG00000142347 (from geneSymbol) uc338klx.1 uc338klx.1 
ENSMUST00000370507.1 ENSMUSG00000142348 ENSMUST00000370507.1 ENSMUSG00000142348 (from geneSymbol) uc338klz.1 uc338klz.1 
ENSMUST00000370508.1 ENSMUSG00000142349 ENSMUST00000370508.1 ENSMUSG00000142349 (from geneSymbol) uc338kma.1 uc338kma.1 
ENSMUST00000370509.1 ENSMUSG00000142350 ENSMUST00000370509.1 ENSMUSG00000142350 (from geneSymbol) LF197439 uc338kmb.1 uc338kmb.1 
ENSMUST00000370517.1 D030040B21Rik ENSMUST00000370517.1 D030040B21Rik (from geneSymbol) AK083519 uc338kmj.1 uc338kmj.1 
ENSMUST00000370523.1 ENSMUSG00000142351 ENSMUST00000370523.1 ENSMUSG00000142351 (from geneSymbol) uc338kmp.1 uc338kmp.1 
ENSMUST00000370524.1 ENSMUSG00000142352 ENSMUST00000370524.1 ENSMUSG00000142352 (from geneSymbol) uc338kmq.1 uc338kmq.1 
ENSMUST00000370526.1 ENSMUSG00000142353 ENSMUST00000370526.1 ENSMUSG00000142353 (from geneSymbol) uc338kms.1 uc338kms.1 
ENSMUST00000370527.1 ENSMUSG00000142354 ENSMUST00000370527.1 ENSMUSG00000142354 (from geneSymbol) uc338kmt.1 uc338kmt.1 
ENSMUST00000370528.1 ENSMUSG00000142355 ENSMUST00000370528.1 ENSMUSG00000142355 (from geneSymbol) uc338kmu.1 uc338kmu.1 
ENSMUST00000370529.1 ENSMUSG00000142356 ENSMUST00000370529.1 ENSMUSG00000142356 (from geneSymbol) uc338kmv.1 uc338kmv.1 
ENSMUST00000370530.1 ENSMUSG00000142357 ENSMUST00000370530.1 ENSMUSG00000142357 (from geneSymbol) LF196173 uc338kmw.1 uc338kmw.1 
ENSMUST00000370538.1 ENSMUSG00000142358 ENSMUST00000370538.1 ENSMUSG00000142358 (from geneSymbol) uc338kne.1 uc338kne.1 
ENSMUST00000370540.1 ENSMUSG00000142360 ENSMUST00000370540.1 ENSMUSG00000142360 (from geneSymbol) uc338knf.1 uc338knf.1 
ENSMUST00000370544.1 ENSMUSG00000142361 ENSMUST00000370544.1 ENSMUSG00000142361 (from geneSymbol) uc338knj.1 uc338knj.1 
ENSMUST00000370546.1 ENSMUSG00000142362 ENSMUST00000370546.1 ENSMUSG00000142362 (from geneSymbol) uc338knl.1 uc338knl.1 
ENSMUST00000370549.1 ENSMUSG00000142363 ENSMUST00000370549.1 ENSMUSG00000142363 (from geneSymbol) uc338kno.1 uc338kno.1 
ENSMUST00000370551.1 Gm3728 ENSMUST00000370551.1 Gm3728 (from geneSymbol) AK053416 uc338knq.1 uc338knq.1 
ENSMUST00000370554.1 ENSMUSG00000142364 ENSMUST00000370554.1 ENSMUSG00000142364 (from geneSymbol) uc338knt.1 uc338knt.1 
ENSMUST00000370578.1 ENSMUSG00000144210 ENSMUST00000370578.1 ENSMUSG00000144210 (from geneSymbol) uc338koo.1 uc338koo.1 
ENSMUST00000370590.1 ENSMUSG00000142365 ENSMUST00000370590.1 ENSMUSG00000142365 (from geneSymbol) uc338kpa.1 uc338kpa.1 
ENSMUST00000370592.1 ENSMUSG00000142366 ENSMUST00000370592.1 ENSMUSG00000142366 (from geneSymbol) uc338kpc.1 uc338kpc.1 
ENSMUST00000370594.1 ENSMUSG00000142367 ENSMUST00000370594.1 ENSMUSG00000142367 (from geneSymbol) uc338kpe.1 uc338kpe.1 
ENSMUST00000370595.1 ENSMUSG00000142368 ENSMUST00000370595.1 ENSMUSG00000142368 (from geneSymbol) uc338kpf.1 uc338kpf.1 
ENSMUST00000370598.1 Gm5142 ENSMUST00000370598.1 Gm5142 (from geneSymbol) AK076969 uc338kpi.1 uc338kpi.1 
ENSMUST00000370603.1 ENSMUSG00000142369 ENSMUST00000370603.1 ENSMUSG00000142369 (from geneSymbol) uc338kpn.1 uc338kpn.1 
ENSMUST00000370604.1 ENSMUSG00000142370 ENSMUST00000370604.1 ENSMUSG00000142370 (from geneSymbol) uc338kpo.1 uc338kpo.1 
ENSMUST00000370605.1 Gm32856 ENSMUST00000370605.1 Gm32856 (from geneSymbol) BC027545 uc338kpp.1 uc338kpp.1 
ENSMUST00000370629.1 Gm38619 ENSMUST00000370629.1 Gm38619 (from geneSymbol) uc338kqn.1 uc338kqn.1 
ENSMUST00000370632.1 ENSMUSG00000142371 ENSMUST00000370632.1 ENSMUSG00000142371 (from geneSymbol) uc338kqq.1 uc338kqq.1 
ENSMUST00000370633.1 ENSMUSG00000142372 ENSMUST00000370633.1 ENSMUSG00000142372 (from geneSymbol) uc338kqr.1 uc338kqr.1 
ENSMUST00000370637.1 Stamos ENSMUST00000370637.1 Stamos (from geneSymbol) AK014986 uc338kqv.1 uc338kqv.1 
ENSMUST00000370647.1 9330199G10Rik ENSMUST00000370647.1 9330199G10Rik (from geneSymbol) AK034488 uc338krf.1 uc338krf.1 
ENSMUST00000370649.1 ENSMUSG00000142373 ENSMUST00000370649.1 ENSMUSG00000142373 (from geneSymbol) uc338krh.1 uc338krh.1 
ENSMUST00000370650.1 ENSMUSG00000142374 ENSMUST00000370650.1 ENSMUSG00000142374 (from geneSymbol) uc338kri.1 uc338kri.1 
ENSMUST00000370652.1 Gm41311 ENSMUST00000370652.1 Gm41311 (from geneSymbol) uc338krk.1 uc338krk.1 
ENSMUST00000370661.1 ENSMUSG00000142375 ENSMUST00000370661.1 ENSMUSG00000142375 (from geneSymbol) uc338krt.1 uc338krt.1 
ENSMUST00000370662.1 ENSMUSG00000142376 ENSMUST00000370662.1 ENSMUSG00000142376 (from geneSymbol) uc338kru.1 uc338kru.1 
ENSMUST00000370663.1 ENSMUSG00000142377 ENSMUST00000370663.1 ENSMUSG00000142377 (from geneSymbol) uc338krv.1 uc338krv.1 
ENSMUST00000370664.1 ENSMUSG00000142378 ENSMUST00000370664.1 ENSMUSG00000142378 (from geneSymbol) uc338krw.1 uc338krw.1 
ENSMUST00000370665.1 ENSMUSG00000142379 ENSMUST00000370665.1 ENSMUSG00000142379 (from geneSymbol) uc338krx.1 uc338krx.1 
ENSMUST00000370667.1 ENSMUSG00000142380 ENSMUST00000370667.1 ENSMUSG00000142380 (from geneSymbol) uc338krz.1 uc338krz.1 
ENSMUST00000370675.1 ENSMUSG00000142381 ENSMUST00000370675.1 ENSMUSG00000142381 (from geneSymbol) uc338ksh.1 uc338ksh.1 
ENSMUST00000370680.1 ENSMUSG00000142382 ENSMUST00000370680.1 ENSMUSG00000142382 (from geneSymbol) uc338ksm.1 uc338ksm.1 
ENSMUST00000370681.1 ENSMUSG00000142383 ENSMUST00000370681.1 ENSMUSG00000142383 (from geneSymbol) uc338ksn.1 uc338ksn.1 
ENSMUST00000370686.1 2900040C04Rik ENSMUST00000370686.1 2900040C04Rik (from geneSymbol) uc338kss.1 uc338kss.1 
ENSMUST00000370688.1 ENSMUSG00000142384 ENSMUST00000370688.1 ENSMUSG00000142384 (from geneSymbol) uc338ksu.1 uc338ksu.1 
ENSMUST00000370689.1 ENSMUSG00000142385 ENSMUST00000370689.1 ENSMUSG00000142385 (from geneSymbol) uc338ksv.1 uc338ksv.1 
ENSMUST00000370690.1 ENSMUSG00000142386 ENSMUST00000370690.1 ENSMUSG00000142386 (from geneSymbol) uc338ksw.1 uc338ksw.1 
ENSMUST00000370691.1 ENSMUSG00000142387 ENSMUST00000370691.1 ENSMUSG00000142387 (from geneSymbol) uc338ksx.1 uc338ksx.1 
ENSMUST00000370692.1 Gm56986 ENSMUST00000370692.1 Gm56986 (from geneSymbol) uc338ksy.1 uc338ksy.1 
ENSMUST00000370693.1 ENSMUSG00000142388 ENSMUST00000370693.1 ENSMUSG00000142388 (from geneSymbol) uc338ksz.1 uc338ksz.1 
ENSMUST00000370694.1 ENSMUSG00000142389 ENSMUST00000370694.1 ENSMUSG00000142389 (from geneSymbol) uc338kta.1 uc338kta.1 
ENSMUST00000370696.1 ENSMUSG00000142390 ENSMUST00000370696.1 ENSMUSG00000142390 (from geneSymbol) uc338ktc.1 uc338ktc.1 
ENSMUST00000370699.1 ENSMUSG00000142391 ENSMUST00000370699.1 ENSMUSG00000142391 (from geneSymbol) uc338ktf.1 uc338ktf.1 
ENSMUST00000370700.1 ENSMUSG00000142392 ENSMUST00000370700.1 ENSMUSG00000142392 (from geneSymbol) uc338ktg.1 uc338ktg.1 
ENSMUST00000370702.1 ENSMUSG00000142393 ENSMUST00000370702.1 ENSMUSG00000142393 (from geneSymbol) uc338kti.1 uc338kti.1 
ENSMUST00000370703.1 ENSMUSG00000142394 ENSMUST00000370703.1 ENSMUSG00000142394 (from geneSymbol) uc338ktj.1 uc338ktj.1 
ENSMUST00000370704.1 ENSMUSG00000142395 ENSMUST00000370704.1 ENSMUSG00000142395 (from geneSymbol) uc338ktk.1 uc338ktk.1 
ENSMUST00000370706.1 ENSMUSG00000142396 ENSMUST00000370706.1 ENSMUSG00000142396 (from geneSymbol) uc338ktm.1 uc338ktm.1 
ENSMUST00000370708.1 ENSMUSG00000142397 ENSMUST00000370708.1 ENSMUSG00000142397 (from geneSymbol) uc338kto.1 uc338kto.1 
ENSMUST00000370709.1 ENSMUSG00000142398 ENSMUST00000370709.1 ENSMUSG00000142398 (from geneSymbol) uc338ktp.1 uc338ktp.1 
ENSMUST00000370710.1 ENSMUSG00000142399 ENSMUST00000370710.1 ENSMUSG00000142399 (from geneSymbol) uc338ktq.1 uc338ktq.1 
ENSMUST00000370711.1 ENSMUSG00000142400 ENSMUST00000370711.1 ENSMUSG00000142400 (from geneSymbol) uc338ktr.1 uc338ktr.1 
ENSMUST00000370713.1 Gm13752 ENSMUST00000370713.1 Gm13752 (from geneSymbol) AK139560 uc338ktt.1 uc338ktt.1 
ENSMUST00000370714.1 Gm57335 ENSMUST00000370714.1 Gm57335 (from geneSymbol) uc338ktu.1 uc338ktu.1 
ENSMUST00000370718.1 ENSMUSG00000142401 ENSMUST00000370718.1 ENSMUSG00000142401 (from geneSymbol) uc338kty.1 uc338kty.1 
ENSMUST00000370724.1 ENSMUSG00000142402 ENSMUST00000370724.1 ENSMUSG00000142402 (from geneSymbol) uc338kue.1 uc338kue.1 
ENSMUST00000370734.1 Gm3331 ENSMUST00000370734.1 Gm3331 (from geneSymbol) AK042795 uc338kuo.1 uc338kuo.1 
ENSMUST00000370741.1 ENSMUSG00000142403 ENSMUST00000370741.1 ENSMUSG00000142403 (from geneSymbol) uc338kuv.1 uc338kuv.1 
ENSMUST00000370745.1 Gm21980 ENSMUST00000370745.1 Gm21980 (from geneSymbol) uc338kuz.1 uc338kuz.1 
ENSMUST00000370755.1 ENSMUSG00000142404 ENSMUST00000370755.1 ENSMUSG00000142404 (from geneSymbol) uc338kvj.1 uc338kvj.1 
ENSMUST00000370756.1 ENSMUSG00000142405 ENSMUST00000370756.1 ENSMUSG00000142405 (from geneSymbol) uc338kvk.1 uc338kvk.1 
ENSMUST00000370757.1 ENSMUSG00000142406 ENSMUST00000370757.1 ENSMUSG00000142406 (from geneSymbol) uc338kvl.1 uc338kvl.1 
ENSMUST00000370760.1 ENSMUSG00000142407 ENSMUST00000370760.1 ENSMUSG00000142407 (from geneSymbol) uc338kvo.1 uc338kvo.1 
ENSMUST00000370763.1 ENSMUSG00000142408 ENSMUST00000370763.1 ENSMUSG00000142408 (from geneSymbol) uc338kvr.1 uc338kvr.1 
ENSMUST00000370764.1 ENSMUSG00000142409 ENSMUST00000370764.1 ENSMUSG00000142409 (from geneSymbol) uc338kvs.1 uc338kvs.1 
ENSMUST00000370765.1 ENSMUSG00000142410 ENSMUST00000370765.1 ENSMUSG00000142410 (from geneSymbol) uc338kvt.1 uc338kvt.1 
ENSMUST00000370776.1 1700092C10Rik ENSMUST00000370776.1 1700092C10Rik (from geneSymbol) AK007038 uc338kwe.1 uc338kwe.1 
ENSMUST00000370805.1 ENSMUSG00000142411 ENSMUST00000370805.1 ENSMUSG00000142411 (from geneSymbol) uc338kxh.1 uc338kxh.1 
ENSMUST00000370806.1 Gm11586 ENSMUST00000370806.1 Gm11586 (from geneSymbol) uc338kxi.1 uc338kxi.1 
ENSMUST00000370808.1 6330409D20Rik ENSMUST00000370808.1 RIKEN cDNA 6330409D20 gene, transcript variant 1 (from RefSeq NR_177960.1) NR_177960 uc338kxk.1 uc338kxk.1 
ENSMUST00000370813.1 ENSMUSG00000142412 ENSMUST00000370813.1 ENSMUSG00000142412 (from geneSymbol) uc338kxp.1 uc338kxp.1 
ENSMUST00000370814.1 ENSMUSG00000142413 ENSMUST00000370814.1 ENSMUSG00000142413 (from geneSymbol) uc338kxq.1 uc338kxq.1 
ENSMUST00000370816.1 ENSMUSG00000142414 ENSMUST00000370816.1 ENSMUSG00000142414 (from geneSymbol) uc338kxs.1 uc338kxs.1 
ENSMUST00000370818.1 ENSMUSG00000142415 ENSMUST00000370818.1 ENSMUSG00000142415 (from geneSymbol) uc338kxu.1 uc338kxu.1 
ENSMUST00000370819.1 ENSMUSG00000142416 ENSMUST00000370819.1 ENSMUSG00000142416 (from geneSymbol) uc338kxv.1 uc338kxv.1 
ENSMUST00000370820.1 ENSMUSG00000142417 ENSMUST00000370820.1 ENSMUSG00000142417 (from geneSymbol) uc338kxw.1 uc338kxw.1 
ENSMUST00000370821.1 ENSMUSG00000142418 ENSMUST00000370821.1 ENSMUSG00000142418 (from geneSymbol) uc338kxx.1 uc338kxx.1 
ENSMUST00000370822.1 Gm29337 ENSMUST00000370822.1 Gm29337 (from geneSymbol) uc338kxy.1 uc338kxy.1 
ENSMUST00000370826.1 ENSMUSG00000142419 ENSMUST00000370826.1 ENSMUSG00000142419 (from geneSymbol) uc338kyc.1 uc338kyc.1 
ENSMUST00000370827.1 ENSMUSG00000142420 ENSMUST00000370827.1 ENSMUSG00000142420 (from geneSymbol) uc338kyd.1 uc338kyd.1 
ENSMUST00000370829.1 ENSMUSG00000142421 ENSMUST00000370829.1 ENSMUSG00000142421 (from geneSymbol) uc338kyf.1 uc338kyf.1 
ENSMUST00000370833.1 ENSMUSG00000142422 ENSMUST00000370833.1 ENSMUSG00000142422 (from geneSymbol) uc338kyj.1 uc338kyj.1 
ENSMUST00000370835.1 ENSMUSG00000142423 ENSMUST00000370835.1 ENSMUSG00000142423 (from geneSymbol) uc338kyl.1 uc338kyl.1 
ENSMUST00000370836.1 ENSMUSG00000142424 ENSMUST00000370836.1 ENSMUSG00000142424 (from geneSymbol) uc338kym.1 uc338kym.1 
ENSMUST00000370837.1 ENSMUSG00000142425 ENSMUST00000370837.1 ENSMUSG00000142425 (from geneSymbol) uc338kyn.1 uc338kyn.1 
ENSMUST00000370845.1 ENSMUSG00000142426 ENSMUST00000370845.1 ENSMUSG00000142426 (from geneSymbol) uc338kyv.1 uc338kyv.1 
ENSMUST00000370847.1 Gm33044 ENSMUST00000370847.1 Gm33044 (from geneSymbol) uc338kyx.1 uc338kyx.1 
ENSMUST00000370853.1 ENSMUSG00000142427 ENSMUST00000370853.1 ENSMUSG00000142427 (from geneSymbol) uc338kzd.1 uc338kzd.1 
ENSMUST00000370858.1 ENSMUSG00000142428 ENSMUST00000370858.1 ENSMUSG00000142428 (from geneSymbol) uc338kzi.1 uc338kzi.1 
ENSMUST00000370859.1 ENSMUSG00000142429 ENSMUST00000370859.1 ENSMUSG00000142429 (from geneSymbol) uc338kzj.1 uc338kzj.1 
ENSMUST00000370861.1 ENSMUSG00000142430 ENSMUST00000370861.1 ENSMUSG00000142430 (from geneSymbol) uc338kzl.1 uc338kzl.1 
ENSMUST00000370862.1 ENSMUSG00000142431 ENSMUST00000370862.1 ENSMUSG00000142431 (from geneSymbol) uc338kzm.1 uc338kzm.1 
ENSMUST00000370865.1 ENSMUSG00000142432 ENSMUST00000370865.1 ENSMUSG00000142432 (from geneSymbol) uc338kzp.1 uc338kzp.1 
ENSMUST00000370866.1 ENSMUSG00000142433 ENSMUST00000370866.1 ENSMUSG00000142433 (from geneSymbol) LF199030 uc338kzq.1 uc338kzq.1 
ENSMUST00000370874.1 ENSMUSG00000142434 ENSMUST00000370874.1 ENSMUSG00000142434 (from geneSymbol) uc338kzy.1 uc338kzy.1 
ENSMUST00000370877.1 ENSMUSG00000142435 ENSMUST00000370877.1 ENSMUSG00000142435 (from geneSymbol) uc338lab.1 uc338lab.1 
ENSMUST00000370879.1 ENSMUSG00000142436 ENSMUST00000370879.1 ENSMUSG00000142436 (from geneSymbol) uc338lad.1 uc338lad.1 
ENSMUST00000370881.1 ENSMUSG00000142437 ENSMUST00000370881.1 ENSMUSG00000142437 (from geneSymbol) uc338laf.1 uc338laf.1 
ENSMUST00000370888.1 ENSMUSG00000142438 ENSMUST00000370888.1 ENSMUSG00000142438 (from geneSymbol) uc338lam.1 uc338lam.1 
ENSMUST00000370896.1 Gm57068 ENSMUST00000370896.1 Gm57068 (from geneSymbol) KY467982 uc338lau.1 uc338lau.1 
ENSMUST00000370902.1 ENSMUSG00000142440 ENSMUST00000370902.1 ENSMUSG00000142440 (from geneSymbol) uc338lba.1 uc338lba.1 
ENSMUST00000370907.1 ENSMUSG00000142441 ENSMUST00000370907.1 ENSMUSG00000142441 (from geneSymbol) uc338lbf.1 uc338lbf.1 
ENSMUST00000370910.1 ENSMUSG00000142442 ENSMUST00000370910.1 ENSMUSG00000142442 (from geneSymbol) BC072647 uc338lbi.1 uc338lbi.1 
ENSMUST00000370940.1 ENSMUSG00000142443 ENSMUST00000370940.1 ENSMUSG00000142443 (from geneSymbol) uc338lcm.1 uc338lcm.1 
ENSMUST00000370945.1 ENSMUSG00000142444 ENSMUST00000370945.1 ENSMUSG00000142444 (from geneSymbol) uc338lcr.1 uc338lcr.1 
ENSMUST00000370953.1 A330087D11Rik ENSMUST00000370953.1 A330087D11Rik (from geneSymbol) uc338lcz.1 uc338lcz.1 
ENSMUST00000370974.1 4930559C10Rik ENSMUST00000370974.1 4930559C10Rik (from geneSymbol) AK016182 uc338ldu.1 uc338ldu.1 
ENSMUST00000370981.1 ENSMUSG00000142445 ENSMUST00000370981.1 ENSMUSG00000142445 (from geneSymbol) uc338leb.1 uc338leb.1 
ENSMUST00000370983.1 ENSMUSG00000142446 ENSMUST00000370983.1 ENSMUSG00000142446 (from geneSymbol) uc338led.1 uc338led.1 
ENSMUST00000370985.1 ENSMUSG00000142447 ENSMUST00000370985.1 ENSMUSG00000142447 (from geneSymbol) uc338lef.1 uc338lef.1 
ENSMUST00000370988.1 ENSMUSG00000142448 ENSMUST00000370988.1 ENSMUSG00000142448 (from geneSymbol) uc338lei.1 uc338lei.1 
ENSMUST00000370990.1 ENSMUSG00000142449 ENSMUST00000370990.1 ENSMUSG00000142449 (from geneSymbol) uc338lek.1 uc338lek.1 
ENSMUST00000370992.1 ENSMUSG00000142450 ENSMUST00000370992.1 ENSMUSG00000142450 (from geneSymbol) uc338lem.1 uc338lem.1 
ENSMUST00000370994.1 ENSMUSG00000142451 ENSMUST00000370994.1 ENSMUSG00000142451 (from geneSymbol) uc338leo.1 uc338leo.1 
ENSMUST00000370995.1 ENSMUSG00000142452 ENSMUST00000370995.1 ENSMUSG00000142452 (from geneSymbol) uc338lep.1 uc338lep.1 
ENSMUST00000371009.1 ENSMUSG00000142454 ENSMUST00000371009.1 ENSMUSG00000142454 (from geneSymbol) uc338lfc.1 uc338lfc.1 
ENSMUST00000371010.1 ENSMUSG00000142455 ENSMUST00000371010.1 ENSMUSG00000142455 (from geneSymbol) uc338lfd.1 uc338lfd.1 
ENSMUST00000371014.1 ENSMUSG00000142456 ENSMUST00000371014.1 ENSMUSG00000142456 (from geneSymbol) uc338lfh.1 uc338lfh.1 
ENSMUST00000371021.1 ENSMUSG00000142457 ENSMUST00000371021.1 ENSMUSG00000142457 (from geneSymbol) uc338lfo.1 uc338lfo.1 
ENSMUST00000371026.1 ENSMUSG00000142458 ENSMUST00000371026.1 ENSMUSG00000142458 (from geneSymbol) uc338lft.1 uc338lft.1 
ENSMUST00000371029.1 ENSMUSG00000142459 ENSMUST00000371029.1 ENSMUSG00000142459 (from geneSymbol) uc338lfw.1 uc338lfw.1 
ENSMUST00000371032.1 1110038B12Rik ENSMUST00000371032.1 1110038B12Rik (from geneSymbol) AK004150 uc338lfz.1 uc338lfz.1 
ENSMUST00000371083.1 ENSMUSG00000142460 ENSMUST00000371083.1 ENSMUSG00000142460 (from geneSymbol) uc338lhx.1 uc338lhx.1 
ENSMUST00000371084.1 ENSMUSG00000142461 ENSMUST00000371084.1 ENSMUSG00000142461 (from geneSymbol) uc338lhy.1 uc338lhy.1 
ENSMUST00000371086.1 ENSMUSG00000142463 ENSMUST00000371086.1 ENSMUSG00000142463 (from geneSymbol) uc338lhz.1 uc338lhz.1 
ENSMUST00000371087.1 ENSMUSG00000142464 ENSMUST00000371087.1 ENSMUSG00000142464 (from geneSymbol) uc338lia.1 uc338lia.1 
ENSMUST00000371088.1 ENSMUSG00000142465 ENSMUST00000371088.1 ENSMUSG00000142465 (from geneSymbol) uc338lib.1 uc338lib.1 
ENSMUST00000371093.1 ENSMUSG00000142466 ENSMUST00000371093.1 ENSMUSG00000142466 (from geneSymbol) uc338lig.1 uc338lig.1 
ENSMUST00000371096.1 ENSMUSG00000142467 ENSMUST00000371096.1 ENSMUSG00000142467 (from geneSymbol) uc338lij.1 uc338lij.1 
ENSMUST00000371097.1 ENSMUSG00000142468 ENSMUST00000371097.1 ENSMUSG00000142468 (from geneSymbol) uc338lik.1 uc338lik.1 
ENSMUST00000371106.1 ENSMUSG00000142469 ENSMUST00000371106.1 ENSMUSG00000142469 (from geneSymbol) uc338lit.1 uc338lit.1 
ENSMUST00000371110.1 Gm35419 ENSMUST00000371110.1 Gm35419 (from geneSymbol) uc338lix.1 uc338lix.1 
ENSMUST00000371114.1 Gm31718 ENSMUST00000371114.1 Gm31718 (from geneSymbol) AK050164 uc338ljb.1 uc338ljb.1 
ENSMUST00000371173.1 ENSMUSG00000142470 ENSMUST00000371173.1 ENSMUSG00000142470 (from geneSymbol) uc338lli.1 uc338lli.1 
ENSMUST00000371265.1 ENSMUSG00000142471 ENSMUST00000371265.1 ENSMUSG00000142471 (from geneSymbol) uc338low.1 uc338low.1 
ENSMUST00000371267.1 ENSMUSG00000142472 ENSMUST00000371267.1 ENSMUSG00000142472 (from geneSymbol) uc338loy.1 uc338loy.1 
ENSMUST00000371270.1 1700128I11Rik ENSMUST00000371270.1 1700128I11Rik (from geneSymbol) uc338lpa.1 uc338lpa.1 
ENSMUST00000371271.1 ENSMUSG00000142474 ENSMUST00000371271.1 ENSMUSG00000142474 (from geneSymbol) uc338lpb.1 uc338lpb.1 
ENSMUST00000371273.1 ENSMUSG00000142475 ENSMUST00000371273.1 ENSMUSG00000142475 (from geneSymbol) uc338lpd.1 uc338lpd.1 
ENSMUST00000371274.1 ENSMUSG00000142476 ENSMUST00000371274.1 ENSMUSG00000142476 (from geneSymbol) uc338lpe.1 uc338lpe.1 
ENSMUST00000371289.1 ENSMUSG00000142477 ENSMUST00000371289.1 ENSMUSG00000142477 (from geneSymbol) uc338lpt.1 uc338lpt.1 
ENSMUST00000371290.1 ENSMUSG00000142478 ENSMUST00000371290.1 ENSMUSG00000142478 (from geneSymbol) uc338lpu.1 uc338lpu.1 
ENSMUST00000371292.1 ENSMUSG00000142479 ENSMUST00000371292.1 ENSMUSG00000142479 (from geneSymbol) uc338lpw.1 uc338lpw.1 
ENSMUST00000371293.1 ENSMUSG00000142480 ENSMUST00000371293.1 ENSMUSG00000142480 (from geneSymbol) uc338lpx.1 uc338lpx.1 
ENSMUST00000371294.1 ENSMUSG00000142481 ENSMUST00000371294.1 ENSMUSG00000142481 (from geneSymbol) uc338lpy.1 uc338lpy.1 
ENSMUST00000371295.1 ENSMUSG00000142482 ENSMUST00000371295.1 ENSMUSG00000142482 (from geneSymbol) uc338lpz.1 uc338lpz.1 
ENSMUST00000371300.1 ENSMUSG00000142483 ENSMUST00000371300.1 ENSMUSG00000142483 (from geneSymbol) uc338lqe.1 uc338lqe.1 
ENSMUST00000371310.1 ENSMUSG00000142484 ENSMUST00000371310.1 ENSMUSG00000142484 (from geneSymbol) uc338lqn.1 uc338lqn.1 
ENSMUST00000371311.1 ENSMUSG00000142485 ENSMUST00000371311.1 ENSMUSG00000142485 (from geneSymbol) uc338lqo.1 uc338lqo.1 
ENSMUST00000371312.1 ENSMUSG00000142486 ENSMUST00000371312.1 ENSMUSG00000142486 (from geneSymbol) uc338lqp.1 uc338lqp.1 
ENSMUST00000371317.1 ENSMUSG00000142487 ENSMUST00000371317.1 ENSMUSG00000142487 (from geneSymbol) uc338lqu.1 uc338lqu.1 
ENSMUST00000371318.1 ENSMUSG00000142488 ENSMUST00000371318.1 ENSMUSG00000142488 (from geneSymbol) uc338lqv.1 uc338lqv.1 
ENSMUST00000371319.1 ENSMUSG00000142489 ENSMUST00000371319.1 ENSMUSG00000142489 (from geneSymbol) uc338lqw.1 uc338lqw.1 
ENSMUST00000371327.1 ENSMUSG00000142490 ENSMUST00000371327.1 ENSMUSG00000142490 (from geneSymbol) uc338lre.1 uc338lre.1 
ENSMUST00000371351.1 ENSMUSG00000142491 ENSMUST00000371351.1 ENSMUSG00000142491 (from geneSymbol) uc338lsc.1 uc338lsc.1 
ENSMUST00000371352.1 ENSMUSG00000142492 ENSMUST00000371352.1 ENSMUSG00000142492 (from geneSymbol) uc338lsd.1 uc338lsd.1 
ENSMUST00000371353.1 Dreh ENSMUST00000371353.1 Dreh (from geneSymbol) AK050349 uc338lse.1 uc338lse.1 
ENSMUST00000371356.1 1700126G02Rik ENSMUST00000371356.1 1700126G02Rik (from geneSymbol) AK007288 uc338lsh.1 uc338lsh.1 
ENSMUST00000371361.1 ENSMUSG00000142493 ENSMUST00000371361.1 ENSMUSG00000142493 (from geneSymbol) uc338lsm.1 uc338lsm.1 
ENSMUST00000371372.1 Gm11827 ENSMUST00000371372.1 Gm11827 (from geneSymbol) KY467966 uc338lsx.1 uc338lsx.1 
ENSMUST00000371374.1 ENSMUSG00000142494 ENSMUST00000371374.1 ENSMUSG00000142494 (from geneSymbol) uc338lsz.1 uc338lsz.1 
ENSMUST00000371383.1 Gm43838 ENSMUST00000371383.1 Gm43838 (from geneSymbol) AK021093 uc338lti.1 uc338lti.1 
ENSMUST00000371392.1 ENSMUSG00000142495 ENSMUST00000371392.1 ENSMUSG00000142495 (from geneSymbol) uc338ltr.1 uc338ltr.1 
ENSMUST00000371420.1 ENSMUSG00000142496 ENSMUST00000371420.1 ENSMUSG00000142496 (from geneSymbol) uc338lut.1 uc338lut.1 
ENSMUST00000371421.1 ENSMUSG00000142497 ENSMUST00000371421.1 ENSMUSG00000142497 (from geneSymbol) uc338luu.1 uc338luu.1 
ENSMUST00000371427.1 ENSMUSG00000142498 ENSMUST00000371427.1 ENSMUSG00000142498 (from geneSymbol) uc338lva.1 uc338lva.1 
ENSMUST00000371428.1 ENSMUSG00000142499 ENSMUST00000371428.1 ENSMUSG00000142499 (from geneSymbol) AK041193 uc338lvb.1 uc338lvb.1 
ENSMUST00000371429.1 ENSMUSG00000142500 ENSMUST00000371429.1 ENSMUSG00000142500 (from geneSymbol) uc338lvc.1 uc338lvc.1 
ENSMUST00000371433.1 ENSMUSG00000142501 ENSMUST00000371433.1 ENSMUSG00000142501 (from geneSymbol) uc338lvg.1 uc338lvg.1 
ENSMUST00000371436.1 ENSMUSG00000142503 ENSMUST00000371436.1 ENSMUSG00000142503 (from geneSymbol) uc338lvi.1 uc338lvi.1 
ENSMUST00000371437.1 ENSMUSG00000142504 ENSMUST00000371437.1 ENSMUSG00000142504 (from geneSymbol) uc338lvj.1 uc338lvj.1 
ENSMUST00000371442.1 ENSMUSG00000142505 ENSMUST00000371442.1 ENSMUSG00000142505 (from geneSymbol) uc338lvo.1 uc338lvo.1 
ENSMUST00000371444.1 ENSMUSG00000142506 ENSMUST00000371444.1 ENSMUSG00000142506 (from geneSymbol) uc338lvq.1 uc338lvq.1 
ENSMUST00000371445.1 ENSMUSG00000142507 ENSMUST00000371445.1 ENSMUSG00000142507 (from geneSymbol) uc338lvr.1 uc338lvr.1 
ENSMUST00000371449.1 ENSMUSG00000142508 ENSMUST00000371449.1 ENSMUSG00000142508 (from geneSymbol) uc338lvv.1 uc338lvv.1 
ENSMUST00000371459.1 ENSMUSG00000142509 ENSMUST00000371459.1 ENSMUSG00000142509 (from geneSymbol) AK006024 uc338lwf.1 uc338lwf.1 
ENSMUST00000371474.1 ENSMUSG00000142510 ENSMUST00000371474.1 ENSMUSG00000142510 (from geneSymbol) uc338lwu.1 uc338lwu.1 
ENSMUST00000371481.1 ENSMUSG00000142512 ENSMUST00000371481.1 ENSMUSG00000142512 (from geneSymbol) uc338lxa.1 uc338lxa.1 
ENSMUST00000371482.1 ENSMUSG00000142513 ENSMUST00000371482.1 ENSMUSG00000142513 (from geneSymbol) uc338lxb.1 uc338lxb.1 
ENSMUST00000371486.1 ENSMUSG00000142514 ENSMUST00000371486.1 ENSMUSG00000142514 (from geneSymbol) uc338lxf.1 uc338lxf.1 
ENSMUST00000371495.1 ENSMUSG00000142515 ENSMUST00000371495.1 ENSMUSG00000142515 (from geneSymbol) uc338lxo.1 uc338lxo.1 
ENSMUST00000371496.1 Gm17705 ENSMUST00000371496.1 Gm17705 (from geneSymbol) AK054225 uc338lxp.1 uc338lxp.1 
ENSMUST00000371498.1 ENSMUSG00000142516 ENSMUST00000371498.1 ENSMUSG00000142516 (from geneSymbol) uc338lxr.1 uc338lxr.1 
ENSMUST00000371499.1 A630001O12Rik ENSMUST00000371499.1 A630001O12Rik (from geneSymbol) AK172442 uc338lxs.1 uc338lxs.1 
ENSMUST00000371501.1 ENSMUSG00000142517 ENSMUST00000371501.1 ENSMUSG00000142517 (from geneSymbol) LF198526 uc338lxu.1 uc338lxu.1 
ENSMUST00000371502.1 ENSMUSG00000142518 ENSMUST00000371502.1 ENSMUSG00000142518 (from geneSymbol) uc338lxv.1 uc338lxv.1 
ENSMUST00000371508.1 ENSMUSG00000142519 ENSMUST00000371508.1 ENSMUSG00000142519 (from geneSymbol) uc338lyb.1 uc338lyb.1 
ENSMUST00000371512.1 ENSMUSG00000142520 ENSMUST00000371512.1 ENSMUSG00000142520 (from geneSymbol) uc338lyf.1 uc338lyf.1 
ENSMUST00000371513.1 ENSMUSG00000142521 ENSMUST00000371513.1 ENSMUSG00000142521 (from geneSymbol) uc338lyg.1 uc338lyg.1 
ENSMUST00000371514.1 Gm56498 ENSMUST00000371514.1 Gm56498 (from geneSymbol) uc338lyh.1 uc338lyh.1 
ENSMUST00000371515.1 Gm15958 ENSMUST00000371515.1 Gm15958 (from geneSymbol) AK138348 uc338lyi.1 uc338lyi.1 
ENSMUST00000371517.1 ENSMUSG00000142522 ENSMUST00000371517.1 ENSMUSG00000142522 (from geneSymbol) uc338lyj.1 uc338lyj.1 
ENSMUST00000371529.1 ENSMUSG00000142523 ENSMUST00000371529.1 ENSMUSG00000142523 (from geneSymbol) uc338lyv.1 uc338lyv.1 
ENSMUST00000371533.1 ENSMUSG00000142524 ENSMUST00000371533.1 ENSMUSG00000142524 (from geneSymbol) uc338lyz.1 uc338lyz.1 
ENSMUST00000371535.1 ENSMUSG00000142525 ENSMUST00000371535.1 ENSMUSG00000142525 (from geneSymbol) uc338lzb.1 uc338lzb.1 
ENSMUST00000371538.1 Gm47990 ENSMUST00000371538.1 Gm47990 (from geneSymbol) uc338lze.1 uc338lze.1 
ENSMUST00000371547.1 ENSMUSG00000142527 ENSMUST00000371547.1 ENSMUSG00000142527 (from geneSymbol) uc338lzl.1 uc338lzl.1 
ENSMUST00000371552.1 ENSMUSG00000142528 ENSMUST00000371552.1 ENSMUSG00000142528 (from geneSymbol) uc338lzq.1 uc338lzq.1 
ENSMUST00000371555.1 ENSMUSG00000142529 ENSMUST00000371555.1 ENSMUSG00000142529 (from geneSymbol) uc338lzt.1 uc338lzt.1 
ENSMUST00000371572.1 ENSMUSG00000142530 ENSMUST00000371572.1 ENSMUSG00000142530 (from geneSymbol) uc338mak.1 uc338mak.1 
ENSMUST00000371582.1 ENSMUSG00000142531 ENSMUST00000371582.1 ENSMUSG00000142531 (from geneSymbol) uc338mau.1 uc338mau.1 
ENSMUST00000371586.1 Gm15787 ENSMUST00000371586.1 Gm15787 (from geneSymbol) AK053084 uc338may.1 uc338may.1 
ENSMUST00000371601.1 ENSMUSG00000142532 ENSMUST00000371601.1 ENSMUSG00000142532 (from geneSymbol) uc338mbn.1 uc338mbn.1 
ENSMUST00000371602.1 ENSMUSG00000142533 ENSMUST00000371602.1 ENSMUSG00000142533 (from geneSymbol) uc338mbo.1 uc338mbo.1 
ENSMUST00000371608.1 ENSMUSG00000142534 ENSMUST00000371608.1 ENSMUSG00000142534 (from geneSymbol) uc338mbu.1 uc338mbu.1 
ENSMUST00000371621.1 ENSMUSG00000142535 ENSMUST00000371621.1 ENSMUSG00000142535 (from geneSymbol) uc338mch.1 uc338mch.1 
ENSMUST00000371622.1 Gm30684 ENSMUST00000371622.1 Gm30684 (from geneSymbol) uc338mci.1 uc338mci.1 
ENSMUST00000371632.1 ENSMUSG00000142536 ENSMUST00000371632.1 ENSMUSG00000142536 (from geneSymbol) uc338mcr.1 uc338mcr.1 
ENSMUST00000371641.1 ENSMUSG00000142537 ENSMUST00000371641.1 ENSMUSG00000142537 (from geneSymbol) uc338mda.1 uc338mda.1 
ENSMUST00000371642.1 ENSMUSG00000142538 ENSMUST00000371642.1 ENSMUSG00000142538 (from geneSymbol) uc338mdb.1 uc338mdb.1 
ENSMUST00000371644.1 ENSMUSG00000142539 ENSMUST00000371644.1 ENSMUSG00000142539 (from geneSymbol) uc338mdd.1 uc338mdd.1 
ENSMUST00000371646.1 ENSMUSG00000142540 ENSMUST00000371646.1 ENSMUSG00000142540 (from geneSymbol) uc338mdf.1 uc338mdf.1 
ENSMUST00000371648.1 ENSMUSG00000142541 ENSMUST00000371648.1 ENSMUSG00000142541 (from geneSymbol) uc338mdh.1 uc338mdh.1 
ENSMUST00000371649.1 ENSMUSG00000142542 ENSMUST00000371649.1 ENSMUSG00000142542 (from geneSymbol) uc338mdi.1 uc338mdi.1 
ENSMUST00000371652.1 ENSMUSG00000142543 ENSMUST00000371652.1 ENSMUSG00000142543 (from geneSymbol) uc338mdl.1 uc338mdl.1 
ENSMUST00000371657.1 ENSMUSG00000142544 ENSMUST00000371657.1 ENSMUSG00000142544 (from geneSymbol) uc338mdq.1 uc338mdq.1 
ENSMUST00000371658.1 ENSMUSG00000142545 ENSMUST00000371658.1 ENSMUSG00000142545 (from geneSymbol) uc338mdr.1 uc338mdr.1 
ENSMUST00000371659.1 ENSMUSG00000142546 ENSMUST00000371659.1 ENSMUSG00000142546 (from geneSymbol) uc338mds.1 uc338mds.1 
ENSMUST00000371661.1 ENSMUSG00000142547 ENSMUST00000371661.1 ENSMUSG00000142547 (from geneSymbol) uc338mdu.1 uc338mdu.1 
ENSMUST00000371662.1 ENSMUSG00000142548 ENSMUST00000371662.1 ENSMUSG00000142548 (from geneSymbol) uc338mdv.1 uc338mdv.1 
ENSMUST00000371663.1 ENSMUSG00000142549 ENSMUST00000371663.1 ENSMUSG00000142549 (from geneSymbol) uc338mdw.1 uc338mdw.1 
ENSMUST00000371665.1 ENSMUSG00000142550 ENSMUST00000371665.1 ENSMUSG00000142550 (from geneSymbol) uc338mdy.1 uc338mdy.1 
ENSMUST00000371676.1 ENSMUSG00000142551 ENSMUST00000371676.1 ENSMUSG00000142551 (from geneSymbol) uc338mej.1 uc338mej.1 
ENSMUST00000371679.1 ENSMUSG00000142552 ENSMUST00000371679.1 ENSMUSG00000142552 (from geneSymbol) uc338mem.1 uc338mem.1 
ENSMUST00000371681.1 ENSMUSG00000142553 ENSMUST00000371681.1 ENSMUSG00000142553 (from geneSymbol) uc338meo.1 uc338meo.1 
ENSMUST00000371682.1 ENSMUSG00000142554 ENSMUST00000371682.1 ENSMUSG00000142554 (from geneSymbol) uc338mep.1 uc338mep.1 
ENSMUST00000371683.1 ENSMUSG00000142555 ENSMUST00000371683.1 ENSMUSG00000142555 (from geneSymbol) uc338meq.1 uc338meq.1 
ENSMUST00000371696.1 Gm16835 ENSMUST00000371696.1 Gm16835 (from geneSymbol) AK133441 uc338mfd.1 uc338mfd.1 
ENSMUST00000371770.1 ENSMUSG00000142556 ENSMUST00000371770.1 ENSMUSG00000142556 (from geneSymbol) uc338mhz.1 uc338mhz.1 
ENSMUST00000371773.1 ENSMUSG00000142557 ENSMUST00000371773.1 ENSMUSG00000142557 (from geneSymbol) uc338mic.1 uc338mic.1 
ENSMUST00000371775.1 ENSMUSG00000142558 ENSMUST00000371775.1 ENSMUSG00000142558 (from geneSymbol) uc338mie.1 uc338mie.1 
ENSMUST00000371776.1 ENSMUSG00000142559 ENSMUST00000371776.1 ENSMUSG00000142559 (from geneSymbol) uc338mif.1 uc338mif.1 
ENSMUST00000371777.1 ENSMUSG00000142560 ENSMUST00000371777.1 ENSMUSG00000142560 (from geneSymbol) uc338mig.1 uc338mig.1 
ENSMUST00000371780.1 ENSMUSG00000142561 ENSMUST00000371780.1 ENSMUSG00000142561 (from geneSymbol) uc338mij.1 uc338mij.1 
ENSMUST00000371781.1 ENSMUSG00000142562 ENSMUST00000371781.1 ENSMUSG00000142562 (from geneSymbol) uc338mik.1 uc338mik.1 
ENSMUST00000371782.1 Zfp335os ENSMUST00000371782.1 Zfp335os (from geneSymbol) AK141411 uc338mil.1 uc338mil.1 
ENSMUST00000371783.1 ENSMUSG00000142563 ENSMUST00000371783.1 ENSMUSG00000142563 (from geneSymbol) uc338mim.1 uc338mim.1 
ENSMUST00000371785.1 Gm36208 ENSMUST00000371785.1 Gm36208 (from geneSymbol) uc338mio.1 uc338mio.1 
ENSMUST00000371787.1 ENSMUSG00000142564 ENSMUST00000371787.1 ENSMUSG00000142564 (from geneSymbol) uc338miq.1 uc338miq.1 
ENSMUST00000371788.1 ENSMUSG00000142565 ENSMUST00000371788.1 ENSMUSG00000142565 (from geneSymbol) uc338mir.1 uc338mir.1 
ENSMUST00000371789.1 ENSMUSG00000142566 ENSMUST00000371789.1 ENSMUSG00000142566 (from geneSymbol) uc338mis.1 uc338mis.1 
ENSMUST00000371790.1 ENSMUSG00000142567 ENSMUST00000371790.1 ENSMUSG00000142567 (from geneSymbol) uc338mit.1 uc338mit.1 
ENSMUST00000371793.1 ENSMUSG00000142568 ENSMUST00000371793.1 ENSMUSG00000142568 (from geneSymbol) uc338miw.1 uc338miw.1 
ENSMUST00000371794.1 ENSMUSG00000142569 ENSMUST00000371794.1 ENSMUSG00000142569 (from geneSymbol) uc338mix.1 uc338mix.1 
ENSMUST00000371795.1 ENSMUSG00000142570 ENSMUST00000371795.1 ENSMUSG00000142570 (from geneSymbol) uc338miy.1 uc338miy.1 
ENSMUST00000371797.1 ENSMUSG00000142571 ENSMUST00000371797.1 ENSMUSG00000142571 (from geneSymbol) uc338mja.1 uc338mja.1 
ENSMUST00000371799.1 ENSMUSG00000142572 ENSMUST00000371799.1 ENSMUSG00000142572 (from geneSymbol) uc338mjc.1 uc338mjc.1 
ENSMUST00000371800.1 ENSMUSG00000142573 ENSMUST00000371800.1 ENSMUSG00000142573 (from geneSymbol) uc338mjd.1 uc338mjd.1 
ENSMUST00000371801.1 ENSMUSG00000142574 ENSMUST00000371801.1 ENSMUSG00000142574 (from geneSymbol) uc338mje.1 uc338mje.1 
ENSMUST00000371803.1 ENSMUSG00000142575 ENSMUST00000371803.1 ENSMUSG00000142575 (from geneSymbol) uc338mjg.1 uc338mjg.1 
ENSMUST00000371807.1 ENSMUSG00000142576 ENSMUST00000371807.1 ENSMUSG00000142576 (from geneSymbol) uc338mjk.1 uc338mjk.1 
ENSMUST00000371808.1 ENSMUSG00000142577 ENSMUST00000371808.1 ENSMUSG00000142577 (from geneSymbol) uc338mjl.1 uc338mjl.1 
ENSMUST00000371809.1 1700017G19Rik ENSMUST00000371809.1 1700017G19Rik (from geneSymbol) AK006064 uc338mjm.1 uc338mjm.1 
ENSMUST00000371848.1 Hoxd3os1 ENSMUST00000371848.1 Hoxd3os1 (from geneSymbol) AK054396 uc338mkz.1 uc338mkz.1 
ENSMUST00000371860.1 ENSMUSG00000142578 ENSMUST00000371860.1 ENSMUSG00000142578 (from geneSymbol) uc338mll.1 uc338mll.1 
ENSMUST00000371861.1 Gm30771 ENSMUST00000371861.1 Gm30771 (from geneSymbol) uc338mlm.1 uc338mlm.1 
ENSMUST00000371868.1 Gm12905 ENSMUST00000371868.1 Gm12905 (from geneSymbol) AK132422 uc338mls.1 uc338mls.1 
ENSMUST00000371932.1 ENSMUSG00000142579 ENSMUST00000371932.1 ENSMUSG00000142579 (from geneSymbol) uc338moe.1 uc338moe.1 
ENSMUST00000371934.1 4930542C21Rik ENSMUST00000371934.1 RIKEN cDNA 4930542C21 gene (from RefSeq NR_040565.1) NR_040565 uc338mog.1 uc338mog.1 
ENSMUST00000371946.1 ENSMUSG00000142581 ENSMUST00000371946.1 ENSMUSG00000142581 (from geneSymbol) uc338mos.1 uc338mos.1 
ENSMUST00000371951.1 ENSMUSG00000142582 ENSMUST00000371951.1 ENSMUSG00000142582 (from geneSymbol) uc338mox.1 uc338mox.1 
ENSMUST00000371953.1 ENSMUSG00000142584 ENSMUST00000371953.1 ENSMUSG00000142584 (from geneSymbol) uc338moy.1 uc338moy.1 
ENSMUST00000371955.1 ENSMUSG00000142585 ENSMUST00000371955.1 ENSMUSG00000142585 (from geneSymbol) uc338mpa.1 uc338mpa.1 
ENSMUST00000371959.1 ENSMUSG00000142586 ENSMUST00000371959.1 ENSMUSG00000142586 (from geneSymbol) uc338mpe.1 uc338mpe.1 
ENSMUST00000371960.1 ENSMUSG00000142587 ENSMUST00000371960.1 ENSMUSG00000142587 (from geneSymbol) uc338mpf.1 uc338mpf.1 
ENSMUST00000371963.1 Gm38037 ENSMUST00000371963.1 Gm38037 (from geneSymbol) uc338mpi.1 uc338mpi.1 
ENSMUST00000371968.1 ENSMUSG00000142588 ENSMUST00000371968.1 ENSMUSG00000142588 (from geneSymbol) uc338mpn.1 uc338mpn.1 
ENSMUST00000371969.1 ENSMUSG00000142589 ENSMUST00000371969.1 ENSMUSG00000142589 (from geneSymbol) uc338mpo.1 uc338mpo.1 
ENSMUST00000371971.1 ENSMUSG00000142590 ENSMUST00000371971.1 ENSMUSG00000142590 (from geneSymbol) uc338mpq.1 uc338mpq.1 
ENSMUST00000371972.1 ENSMUSG00000142591 ENSMUST00000371972.1 ENSMUSG00000142591 (from geneSymbol) uc338mpr.1 uc338mpr.1 
ENSMUST00000371975.1 ENSMUSG00000142592 ENSMUST00000371975.1 ENSMUSG00000142592 (from geneSymbol) uc338mpu.1 uc338mpu.1 
ENSMUST00000371978.1 ENSMUSG00000142593 ENSMUST00000371978.1 ENSMUSG00000142593 (from geneSymbol) uc338mpx.1 uc338mpx.1 
ENSMUST00000371979.1 ENSMUSG00000142594 ENSMUST00000371979.1 ENSMUSG00000142594 (from geneSymbol) uc338mpy.1 uc338mpy.1 
ENSMUST00000371982.1 ENSMUSG00000142595 ENSMUST00000371982.1 ENSMUSG00000142595 (from geneSymbol) uc338mqb.1 uc338mqb.1 
ENSMUST00000371985.1 ENSMUSG00000142596 ENSMUST00000371985.1 ENSMUSG00000142596 (from geneSymbol) uc338mqe.1 uc338mqe.1 
ENSMUST00000371988.1 ENSMUSG00000142597 ENSMUST00000371988.1 ENSMUSG00000142597 (from geneSymbol) uc338mqh.1 uc338mqh.1 
ENSMUST00000371991.1 ENSMUSG00000142598 ENSMUST00000371991.1 ENSMUSG00000142598 (from geneSymbol) uc338mqk.1 uc338mqk.1 
ENSMUST00000371995.1 ENSMUSG00000142599 ENSMUST00000371995.1 ENSMUSG00000142599 (from geneSymbol) uc338mqo.1 uc338mqo.1 
ENSMUST00000371997.1 ENSMUSG00000142600 ENSMUST00000371997.1 ENSMUSG00000142600 (from geneSymbol) uc338mqq.1 uc338mqq.1 
ENSMUST00000371999.1 ENSMUSG00000142601 ENSMUST00000371999.1 ENSMUSG00000142601 (from geneSymbol) uc338mqs.1 uc338mqs.1 
ENSMUST00000372013.1 ENSMUSG00000142602 ENSMUST00000372013.1 ENSMUSG00000142602 (from geneSymbol) uc338mrg.1 uc338mrg.1 
ENSMUST00000372014.1 ENSMUSG00000142603 ENSMUST00000372014.1 ENSMUSG00000142603 (from geneSymbol) uc338mrh.1 uc338mrh.1 
ENSMUST00000372015.1 Gm49753 ENSMUST00000372015.1 Gm49753 (from geneSymbol) uc338mri.1 uc338mri.1 
ENSMUST00000372018.1 Gm56580 ENSMUST00000372018.1 Gm56580 (from geneSymbol) uc338mrl.1 uc338mrl.1 
ENSMUST00000372019.1 ENSMUSG00000142604 ENSMUST00000372019.1 ENSMUSG00000142604 (from geneSymbol) uc338mrm.1 uc338mrm.1 
ENSMUST00000372021.1 ENSMUSG00000142605 ENSMUST00000372021.1 ENSMUSG00000142605 (from geneSymbol) uc338mro.1 uc338mro.1 
ENSMUST00000372022.1 ENSMUSG00000142606 ENSMUST00000372022.1 ENSMUSG00000142606 (from geneSymbol) uc338mrp.1 uc338mrp.1 
ENSMUST00000372023.1 Gm40646 ENSMUST00000372023.1 Gm40646 (from geneSymbol) uc338mrq.1 uc338mrq.1 
ENSMUST00000372042.1 ENSMUSG00000142607 ENSMUST00000372042.1 ENSMUSG00000142607 (from geneSymbol) uc338msj.1 uc338msj.1 
ENSMUST00000372044.1 ENSMUSG00000142608 ENSMUST00000372044.1 ENSMUSG00000142608 (from geneSymbol) uc338msl.1 uc338msl.1 
ENSMUST00000372050.1 ENSMUSG00000142609 ENSMUST00000372050.1 ENSMUSG00000142609 (from geneSymbol) uc338msr.1 uc338msr.1 
ENSMUST00000372053.1 ENSMUSG00000142610 ENSMUST00000372053.1 ENSMUSG00000142610 (from geneSymbol) uc338msu.1 uc338msu.1 
ENSMUST00000372055.1 ENSMUSG00000142611 ENSMUST00000372055.1 ENSMUSG00000142611 (from geneSymbol) uc338msw.1 uc338msw.1 
ENSMUST00000372056.1 ENSMUSG00000142612 ENSMUST00000372056.1 ENSMUSG00000142612 (from geneSymbol) uc338msx.1 uc338msx.1 
ENSMUST00000372057.1 ENSMUSG00000142613 ENSMUST00000372057.1 predicted gene 2192 (from RefSeq NR_152161.1) NR_152161 uc338msy.1 uc338msy.1 
ENSMUST00000372098.1 ENSMUSG00000142614 ENSMUST00000372098.1 ENSMUSG00000142614 (from geneSymbol) uc338mun.1 uc338mun.1 
ENSMUST00000372101.1 ENSMUSG00000142615 ENSMUST00000372101.1 ENSMUSG00000142615 (from geneSymbol) uc338muq.1 uc338muq.1 
ENSMUST00000372102.1 ENSMUSG00000142616 ENSMUST00000372102.1 ENSMUSG00000142616 (from geneSymbol) uc338mur.1 uc338mur.1 
ENSMUST00000372110.1 ENSMUSG00000142617 ENSMUST00000372110.1 ENSMUSG00000142617 (from geneSymbol) uc338muz.1 uc338muz.1 
ENSMUST00000372111.1 Gm46416 ENSMUST00000372111.1 Gm46416 (from geneSymbol) uc338mva.1 uc338mva.1 
ENSMUST00000372119.1 ENSMUSG00000142618 ENSMUST00000372119.1 ENSMUSG00000142618 (from geneSymbol) uc338mvi.1 uc338mvi.1 
ENSMUST00000372123.1 ENSMUSG00000142619 ENSMUST00000372123.1 ENSMUSG00000142619 (from geneSymbol) uc338mvm.1 uc338mvm.1 
ENSMUST00000372130.1 Gm41102 ENSMUST00000372130.1 Gm41102 (from geneSymbol) uc338mvt.1 uc338mvt.1 
ENSMUST00000372143.1 ENSMUSG00000142621 ENSMUST00000372143.1 ENSMUSG00000142621 (from geneSymbol) uc338mwe.1 uc338mwe.1 
ENSMUST00000372153.1 ENSMUSG00000142622 ENSMUST00000372153.1 ENSMUSG00000142622 (from geneSymbol) uc338mwo.1 uc338mwo.1 
ENSMUST00000372154.1 ENSMUSG00000142623 ENSMUST00000372154.1 ENSMUSG00000142623 (from geneSymbol) uc338mwp.1 uc338mwp.1 
ENSMUST00000372160.1 ENSMUSG00000142625 ENSMUST00000372160.1 ENSMUSG00000142625 (from geneSymbol) uc338mwu.1 uc338mwu.1 
ENSMUST00000372172.1 ENSMUSG00000142626 ENSMUST00000372172.1 ENSMUSG00000142626 (from geneSymbol) uc338mxf.1 uc338mxf.1 
ENSMUST00000372174.1 ENSMUSG00000142627 ENSMUST00000372174.1 ENSMUSG00000142627 (from geneSymbol) uc338mxh.1 uc338mxh.1 
ENSMUST00000372175.1 ENSMUSG00000142628 ENSMUST00000372175.1 ENSMUSG00000142628 (from geneSymbol) AK018903 uc338mxi.1 uc338mxi.1 
ENSMUST00000372177.1 Gm41675 ENSMUST00000372177.1 Gm41675 (from geneSymbol) uc338mxk.1 uc338mxk.1 
ENSMUST00000372180.1 ENSMUSG00000142629 ENSMUST00000372180.1 ENSMUSG00000142629 (from geneSymbol) uc338mxn.1 uc338mxn.1 
ENSMUST00000372183.1 Gm26759 ENSMUST00000372183.1 Gm26759 (from geneSymbol) AK050834 uc338mxq.1 uc338mxq.1 
ENSMUST00000372193.1 Gm39317 ENSMUST00000372193.1 Gm39317 (from geneSymbol) uc338mya.1 uc338mya.1 
ENSMUST00000372199.1 ENSMUSG00000142630 ENSMUST00000372199.1 ENSMUSG00000142630 (from geneSymbol) uc338myg.1 uc338myg.1 
ENSMUST00000372206.1 Gm56534 ENSMUST00000372206.1 Gm56534 (from geneSymbol) uc338myn.1 uc338myn.1 
ENSMUST00000372223.1 ENSMUSG00000142631 ENSMUST00000372223.1 ENSMUSG00000142631 (from geneSymbol) uc338mze.1 uc338mze.1 
ENSMUST00000372224.1 ENSMUSG00000142632 ENSMUST00000372224.1 ENSMUSG00000142632 (from geneSymbol) uc338mzf.1 uc338mzf.1 
ENSMUST00000372225.1 ENSMUSG00000142633 ENSMUST00000372225.1 ENSMUSG00000142633 (from geneSymbol) uc338mzg.1 uc338mzg.1 
ENSMUST00000372247.1 ENSMUSG00000142634 ENSMUST00000372247.1 ENSMUSG00000142634 (from geneSymbol) uc338nac.1 uc338nac.1 
ENSMUST00000372248.1 ENSMUSG00000142635 ENSMUST00000372248.1 ENSMUSG00000142635 (from geneSymbol) uc338nad.1 uc338nad.1 
ENSMUST00000372251.1 ENSMUSG00000142636 ENSMUST00000372251.1 ENSMUSG00000142636 (from geneSymbol) uc338nag.1 uc338nag.1 
ENSMUST00000372252.1 ENSMUSG00000142637 ENSMUST00000372252.1 ENSMUSG00000142637 (from geneSymbol) uc338nah.1 uc338nah.1 
ENSMUST00000372254.1 ENSMUSG00000142638 ENSMUST00000372254.1 ENSMUSG00000142638 (from geneSymbol) uc338naj.1 uc338naj.1 
ENSMUST00000372258.1 ENSMUSG00000142639 ENSMUST00000372258.1 ENSMUSG00000142639 (from geneSymbol) uc338nan.1 uc338nan.1 
ENSMUST00000372259.1 ENSMUSG00000142640 ENSMUST00000372259.1 ENSMUSG00000142640 (from geneSymbol) uc338nao.1 uc338nao.1 
ENSMUST00000372302.1 ENSMUSG00000142641 ENSMUST00000372302.1 ENSMUSG00000142641 (from geneSymbol) uc338ncf.1 uc338ncf.1 
ENSMUST00000372310.1 ENSMUSG00000142642 ENSMUST00000372310.1 ENSMUSG00000142642 (from geneSymbol) uc338ncn.1 uc338ncn.1 
ENSMUST00000372318.1 Gm11998 ENSMUST00000372318.1 Gm11998 (from geneSymbol) AK041795 uc338ncv.1 uc338ncv.1 
ENSMUST00000372345.1 ENSMUSG00000142643 ENSMUST00000372345.1 ENSMUSG00000142643 (from geneSymbol) uc338ndw.1 uc338ndw.1 
ENSMUST00000372346.1 ENSMUSG00000142644 ENSMUST00000372346.1 ENSMUSG00000142644 (from geneSymbol) uc338ndx.1 uc338ndx.1 
ENSMUST00000372347.1 Gm45425 ENSMUST00000372347.1 Gm45425 (from geneSymbol) uc338ndy.1 uc338ndy.1 
ENSMUST00000372349.1 1700066B17Rik ENSMUST00000372349.1 1700066B17Rik (from geneSymbol) AK006899 uc338nea.1 uc338nea.1 
ENSMUST00000372432.1 ENSMUSG00000142645 ENSMUST00000372432.1 ENSMUSG00000142645 (from geneSymbol) uc338nhf.1 uc338nhf.1 
ENSMUST00000372434.1 ENSMUSG00000142646 ENSMUST00000372434.1 ENSMUSG00000142646 (from geneSymbol) uc338nhh.1 uc338nhh.1 
ENSMUST00000372440.1 Gm34250 ENSMUST00000372440.1 Gm34250 (from geneSymbol) uc338nhn.1 uc338nhn.1 
ENSMUST00000372445.1 ENSMUSG00000142647 ENSMUST00000372445.1 ENSMUSG00000142647 (from geneSymbol) uc338nhs.1 uc338nhs.1 
ENSMUST00000372451.1 Gm56533 ENSMUST00000372451.1 Gm56533 (from geneSymbol) uc338nhy.1 uc338nhy.1 
ENSMUST00000372466.1 ENSMUSG00000142648 ENSMUST00000372466.1 ENSMUSG00000142648 (from geneSymbol) uc338nin.1 uc338nin.1 
ENSMUST00000372470.1 ENSMUSG00000142649 ENSMUST00000372470.1 ENSMUSG00000142649 (from geneSymbol) uc338nir.1 uc338nir.1 
ENSMUST00000372472.1 ENSMUSG00000142650 ENSMUST00000372472.1 ENSMUSG00000142650 (from geneSymbol) AK031173 uc338nit.1 uc338nit.1 
ENSMUST00000372474.1 ENSMUSG00000142651 ENSMUST00000372474.1 ENSMUSG00000142651 (from geneSymbol) uc338niv.1 uc338niv.1 
ENSMUST00000372477.1 ENSMUSG00000142653 ENSMUST00000372477.1 ENSMUSG00000142653 (from geneSymbol) uc338nix.1 uc338nix.1 
ENSMUST00000372489.1 ENSMUSG00000142654 ENSMUST00000372489.1 ENSMUSG00000142654 (from geneSymbol) uc338njj.1 uc338njj.1 
ENSMUST00000372504.1 ENSMUSG00000142655 ENSMUST00000372504.1 ENSMUSG00000142655 (from geneSymbol) uc338njy.1 uc338njy.1 
ENSMUST00000372506.1 Gm29899 ENSMUST00000372506.1 Gm29899 (from geneSymbol) uc338nka.1 uc338nka.1 
ENSMUST00000372537.1 ENSMUSG00000142656 ENSMUST00000372537.1 ENSMUSG00000142656 (from geneSymbol) uc338nlf.1 uc338nlf.1 
ENSMUST00000372540.1 1700027F09Rik ENSMUST00000372540.1 1700027F09Rik (from geneSymbol) AK006413 uc338nli.1 uc338nli.1 
ENSMUST00000372572.1 ENSMUSG00000142657 ENSMUST00000372572.1 ENSMUSG00000142657 (from geneSymbol) uc338nmo.1 uc338nmo.1 
ENSMUST00000372574.1 ENSMUSG00000142658 ENSMUST00000372574.1 ENSMUSG00000142658 (from geneSymbol) uc338nmq.1 uc338nmq.1 
ENSMUST00000372602.1 ENSMUSG00000142659 ENSMUST00000372602.1 ENSMUSG00000142659 (from geneSymbol) uc338nns.1 uc338nns.1 
ENSMUST00000372606.1 ENSMUSG00000142660 ENSMUST00000372606.1 ENSMUSG00000142660 (from geneSymbol) uc338nnw.1 uc338nnw.1 
ENSMUST00000372608.1 ENSMUSG00000142661 ENSMUST00000372608.1 ENSMUSG00000142661 (from geneSymbol) uc338nny.1 uc338nny.1 
ENSMUST00000372622.1 ENSMUSG00000142662 ENSMUST00000372622.1 ENSMUSG00000142662 (from geneSymbol) uc338nom.1 uc338nom.1 
ENSMUST00000372623.1 ENSMUSG00000142663 ENSMUST00000372623.1 ENSMUSG00000142663 (from geneSymbol) uc338non.1 uc338non.1 
ENSMUST00000372625.1 ENSMUSG00000142664 ENSMUST00000372625.1 ENSMUSG00000142664 (from geneSymbol) uc338nop.1 uc338nop.1 
ENSMUST00000372626.1 ENSMUSG00000142665 ENSMUST00000372626.1 ENSMUSG00000142665 (from geneSymbol) uc338noq.1 uc338noq.1 
ENSMUST00000372628.1 ENSMUSG00000142666 ENSMUST00000372628.1 ENSMUSG00000142666 (from geneSymbol) uc338nos.1 uc338nos.1 
ENSMUST00000372634.1 ENSMUSG00000142667 ENSMUST00000372634.1 ENSMUSG00000142667 (from geneSymbol) uc338noy.1 uc338noy.1 
ENSMUST00000372635.1 ENSMUSG00000142668 ENSMUST00000372635.1 ENSMUSG00000142668 (from geneSymbol) uc338noz.1 uc338noz.1 
ENSMUST00000372641.1 Gm50412 ENSMUST00000372641.1 Gm50412 (from geneSymbol) uc338npf.1 uc338npf.1 
ENSMUST00000372646.1 ENSMUSG00000142669 ENSMUST00000372646.1 ENSMUSG00000142669 (from geneSymbol) uc338npk.1 uc338npk.1 
ENSMUST00000372648.1 ENSMUSG00000142670 ENSMUST00000372648.1 ENSMUSG00000142670 (from geneSymbol) uc338npm.1 uc338npm.1 
ENSMUST00000372652.1 Gm31333 ENSMUST00000372652.1 Gm31333 (from geneSymbol) AK044531 uc338npq.1 uc338npq.1 
ENSMUST00000372695.1 ENSMUSG00000142671 ENSMUST00000372695.1 ENSMUSG00000142671 (from geneSymbol) uc338nrh.1 uc338nrh.1 
ENSMUST00000372696.1 ENSMUSG00000142672 ENSMUST00000372696.1 ENSMUSG00000142672 (from geneSymbol) uc338nri.1 uc338nri.1 
ENSMUST00000372697.1 ENSMUSG00000142673 ENSMUST00000372697.1 ENSMUSG00000142673 (from geneSymbol) uc338nrj.1 uc338nrj.1 
ENSMUST00000372698.1 ENSMUSG00000142674 ENSMUST00000372698.1 ENSMUSG00000142674 (from geneSymbol) uc338nrk.1 uc338nrk.1 
ENSMUST00000372704.1 ENSMUSG00000142675 ENSMUST00000372704.1 ENSMUSG00000142675 (from geneSymbol) uc338nrq.1 uc338nrq.1 
ENSMUST00000372713.1 B230354K17Rik ENSMUST00000372713.1 B230354K17Rik (from geneSymbol) AK162357 uc338nrz.1 uc338nrz.1 
ENSMUST00000372727.1 ENSMUSG00000142676 ENSMUST00000372727.1 ENSMUSG00000142676 (from geneSymbol) uc338nsn.1 uc338nsn.1 
ENSMUST00000372728.1 ENSMUSG00000142677 ENSMUST00000372728.1 ENSMUSG00000142677 (from geneSymbol) uc338nso.1 uc338nso.1 
ENSMUST00000372731.1 ENSMUSG00000142678 ENSMUST00000372731.1 ENSMUSG00000142678 (from geneSymbol) uc338nsr.1 uc338nsr.1 
ENSMUST00000372741.1 ENSMUSG00000142679 ENSMUST00000372741.1 ENSMUSG00000142679 (from geneSymbol) uc338ntb.1 uc338ntb.1 
ENSMUST00000372742.1 ENSMUSG00000142680 ENSMUST00000372742.1 ENSMUSG00000142680 (from geneSymbol) uc338ntc.1 uc338ntc.1 
ENSMUST00000372743.1 ENSMUSG00000142681 ENSMUST00000372743.1 ENSMUSG00000142681 (from geneSymbol) uc338ntd.1 uc338ntd.1 
ENSMUST00000372744.1 ENSMUSG00000142682 ENSMUST00000372744.1 ENSMUSG00000142682 (from geneSymbol) uc338nte.1 uc338nte.1 
ENSMUST00000372746.1 Gm38534 ENSMUST00000372746.1 Gm38534 (from geneSymbol) uc338ntg.1 uc338ntg.1 
ENSMUST00000372775.1 ENSMUSG00000142683 ENSMUST00000372775.1 ENSMUSG00000142683 (from geneSymbol) uc338nuj.1 uc338nuj.1 
ENSMUST00000372776.1 ENSMUSG00000142684 ENSMUST00000372776.1 ENSMUSG00000142684 (from geneSymbol) uc338nuk.1 uc338nuk.1 
ENSMUST00000372778.1 ENSMUSG00000142685 ENSMUST00000372778.1 ENSMUSG00000142685 (from geneSymbol) uc338num.1 uc338num.1 
ENSMUST00000372782.1 ENSMUSG00000142686 ENSMUST00000372782.1 ENSMUSG00000142686 (from geneSymbol) uc338nuq.1 uc338nuq.1 
ENSMUST00000372786.1 Gm49313 ENSMUST00000372786.1 Gm49313 (from geneSymbol) uc338nuu.1 uc338nuu.1 
ENSMUST00000372799.1 ENSMUSG00000142687 ENSMUST00000372799.1 ENSMUSG00000142687 (from geneSymbol) uc338nvh.1 uc338nvh.1 
ENSMUST00000372807.1 ENSMUSG00000142688 ENSMUST00000372807.1 ENSMUSG00000142688 (from geneSymbol) uc338nvp.1 uc338nvp.1 
ENSMUST00000372808.1 ENSMUSG00000142689 ENSMUST00000372808.1 ENSMUSG00000142689 (from geneSymbol) uc338nvq.1 uc338nvq.1 
ENSMUST00000372809.1 ENSMUSG00000142690 ENSMUST00000372809.1 ENSMUSG00000142690 (from geneSymbol) uc338nvr.1 uc338nvr.1 
ENSMUST00000372818.1 ENSMUSG00000142691 ENSMUST00000372818.1 ENSMUSG00000142691 (from geneSymbol) uc338nwa.1 uc338nwa.1 
ENSMUST00000372819.1 ENSMUSG00000142692 ENSMUST00000372819.1 ENSMUSG00000142692 (from geneSymbol) uc338nwb.1 uc338nwb.1 
ENSMUST00000372820.1 ENSMUSG00000142693 ENSMUST00000372820.1 ENSMUSG00000142693 (from geneSymbol) uc338nwc.1 uc338nwc.1 
ENSMUST00000372828.1 ENSMUSG00000142694 ENSMUST00000372828.1 ENSMUSG00000142694 (from geneSymbol) uc338nwk.1 uc338nwk.1 
ENSMUST00000372832.1 ENSMUSG00000142696 ENSMUST00000372832.1 ENSMUSG00000142696 (from geneSymbol) uc338nwl.1 uc338nwl.1 
ENSMUST00000372834.1 ENSMUSG00000142697 ENSMUST00000372834.1 ENSMUSG00000142697 (from geneSymbol) uc338nwn.1 uc338nwn.1 
ENSMUST00000372840.1 ENSMUSG00000142698 ENSMUST00000372840.1 ENSMUSG00000142698 (from geneSymbol) uc338nwt.1 uc338nwt.1 
ENSMUST00000372842.1 ENSMUSG00000142699 ENSMUST00000372842.1 ENSMUSG00000142699 (from geneSymbol) uc338nwv.1 uc338nwv.1 
ENSMUST00000372844.1 ENSMUSG00000142700 ENSMUST00000372844.1 ENSMUSG00000142700 (from geneSymbol) uc338nwx.1 uc338nwx.1 
ENSMUST00000372845.1 ENSMUSG00000142701 ENSMUST00000372845.1 ENSMUSG00000142701 (from geneSymbol) uc338nwy.1 uc338nwy.1 
ENSMUST00000372847.1 ENSMUSG00000142702 ENSMUST00000372847.1 ENSMUSG00000142702 (from geneSymbol) uc338nxa.1 uc338nxa.1 
ENSMUST00000372848.1 ENSMUSG00000142703 ENSMUST00000372848.1 ENSMUSG00000142703 (from geneSymbol) AK131743 uc338nxb.1 uc338nxb.1 
ENSMUST00000372849.1 ENSMUSG00000142704 ENSMUST00000372849.1 ENSMUSG00000142704 (from geneSymbol) uc338nxc.1 uc338nxc.1 
ENSMUST00000372852.1 ENSMUSG00000142706 ENSMUST00000372852.1 ENSMUSG00000142706 (from geneSymbol) uc338nxf.1 uc338nxf.1 
ENSMUST00000372853.1 ENSMUSG00000142707 ENSMUST00000372853.1 ENSMUSG00000142707 (from geneSymbol) uc338nxg.1 uc338nxg.1 
ENSMUST00000372854.1 ENSMUSG00000142708 ENSMUST00000372854.1 ENSMUSG00000142708 (from geneSymbol) uc338nxh.1 uc338nxh.1 
ENSMUST00000372855.1 ENSMUSG00000142709 ENSMUST00000372855.1 ENSMUSG00000142709 (from geneSymbol) uc338nxi.1 uc338nxi.1 
ENSMUST00000372858.1 Gm13412 ENSMUST00000372858.1 Gm13412 (from geneSymbol) uc338nxl.1 uc338nxl.1 
ENSMUST00000372861.1 ENSMUSG00000142710 ENSMUST00000372861.1 ENSMUSG00000142710 (from geneSymbol) uc338nxo.1 uc338nxo.1 
ENSMUST00000372862.1 ENSMUSG00000142711 ENSMUST00000372862.1 ENSMUSG00000142711 (from geneSymbol) uc338nxp.1 uc338nxp.1 
ENSMUST00000372863.1 ENSMUSG00000142712 ENSMUST00000372863.1 ENSMUSG00000142712 (from geneSymbol) uc338nxq.1 uc338nxq.1 
ENSMUST00000372865.1 ENSMUSG00000142713 ENSMUST00000372865.1 ENSMUSG00000142713 (from geneSymbol) uc338nxs.1 uc338nxs.1 
ENSMUST00000372866.1 Gm43691 ENSMUST00000372866.1 Gm43691 (from geneSymbol) uc338nxt.1 uc338nxt.1 
ENSMUST00000372868.1 ENSMUSG00000142714 ENSMUST00000372868.1 ENSMUSG00000142714 (from geneSymbol) uc338nxv.1 uc338nxv.1 
ENSMUST00000372870.1 ENSMUSG00000142715 ENSMUST00000372870.1 ENSMUSG00000142715 (from geneSymbol) uc338nxx.1 uc338nxx.1 
ENSMUST00000372871.1 ENSMUSG00000142716 ENSMUST00000372871.1 ENSMUSG00000142716 (from geneSymbol) uc338nxy.1 uc338nxy.1 
ENSMUST00000372872.1 ENSMUSG00000142717 ENSMUST00000372872.1 ENSMUSG00000142717 (from geneSymbol) uc338nxz.1 uc338nxz.1 
ENSMUST00000372877.1 ENSMUSG00000142718 ENSMUST00000372877.1 ENSMUSG00000142718 (from geneSymbol) uc338nye.1 uc338nye.1 
ENSMUST00000372879.1 ENSMUSG00000142719 ENSMUST00000372879.1 ENSMUSG00000142719 (from geneSymbol) uc338nyg.1 uc338nyg.1 
ENSMUST00000372880.1 ENSMUSG00000142720 ENSMUST00000372880.1 ENSMUSG00000142720 (from geneSymbol) uc338nyh.1 uc338nyh.1 
ENSMUST00000372882.1 ENSMUSG00000142721 ENSMUST00000372882.1 ENSMUSG00000142721 (from geneSymbol) uc338nyj.1 uc338nyj.1 
ENSMUST00000372884.1 ENSMUSG00000142722 ENSMUST00000372884.1 ENSMUSG00000142722 (from geneSymbol) uc338nyl.1 uc338nyl.1 
ENSMUST00000372889.1 ENSMUSG00000142723 ENSMUST00000372889.1 ENSMUSG00000142723 (from geneSymbol) uc338nyq.1 uc338nyq.1 
ENSMUST00000372890.1 ENSMUSG00000142724 ENSMUST00000372890.1 ENSMUSG00000142724 (from geneSymbol) uc338nyr.1 uc338nyr.1 
ENSMUST00000372891.1 ENSMUSG00000142725 ENSMUST00000372891.1 ENSMUSG00000142725 (from geneSymbol) uc338nys.1 uc338nys.1 
ENSMUST00000372892.1 ENSMUSG00000142726 ENSMUST00000372892.1 predicted gene 12625 (from RefSeq NR_172465.1) NR_172465 uc338nyt.1 uc338nyt.1 
ENSMUST00000372897.1 ENSMUSG00000142728 ENSMUST00000372897.1 ENSMUSG00000142728 (from geneSymbol) uc338nyx.1 uc338nyx.1 
ENSMUST00000372946.1 ENSMUSG00000142729 ENSMUST00000372946.1 ENSMUSG00000142729 (from geneSymbol) uc338oau.1 uc338oau.1 
ENSMUST00000372950.1 ENSMUSG00000142730 ENSMUST00000372950.1 ENSMUSG00000142730 (from geneSymbol) uc338oay.1 uc338oay.1 
ENSMUST00000372952.1 ENSMUSG00000142731 ENSMUST00000372952.1 ENSMUSG00000142731 (from geneSymbol) uc338oba.1 uc338oba.1 
ENSMUST00000372955.1 ENSMUSG00000142732 ENSMUST00000372955.1 ENSMUSG00000142732 (from geneSymbol) uc338obd.1 uc338obd.1 
ENSMUST00000372963.1 ENSMUSG00000142733 ENSMUST00000372963.1 ENSMUSG00000142733 (from geneSymbol) uc338obl.1 uc338obl.1 
ENSMUST00000372964.1 ENSMUSG00000142734 ENSMUST00000372964.1 ENSMUSG00000142734 (from geneSymbol) uc338obm.1 uc338obm.1 
ENSMUST00000372966.1 ENSMUSG00000142735 ENSMUST00000372966.1 ENSMUSG00000142735 (from geneSymbol) uc338obo.1 uc338obo.1 
ENSMUST00000372970.1 ENSMUSG00000142736 ENSMUST00000372970.1 ENSMUSG00000142736 (from geneSymbol) uc338obs.1 uc338obs.1 
ENSMUST00000372971.1 1700031P21Rik ENSMUST00000372971.1 1700031P21Rik (from geneSymbol) AK006587 uc338obt.1 uc338obt.1 
ENSMUST00000372991.1 ENSMUSG00000142737 ENSMUST00000372991.1 ENSMUSG00000142737 (from geneSymbol) uc338ocn.1 uc338ocn.1 
ENSMUST00000372996.1 ENSMUSG00000142738 ENSMUST00000372996.1 ENSMUSG00000142738 (from geneSymbol) uc338ocs.1 uc338ocs.1 
ENSMUST00000373007.1 ENSMUSG00000142739 ENSMUST00000373007.1 ENSMUSG00000142739 (from geneSymbol) uc338odd.1 uc338odd.1 
ENSMUST00000373010.1 ENSMUSG00000142740 ENSMUST00000373010.1 ENSMUSG00000142740 (from geneSymbol) uc338odg.1 uc338odg.1 
ENSMUST00000373012.1 ENSMUSG00000142741 ENSMUST00000373012.1 ENSMUSG00000142741 (from geneSymbol) uc338odi.1 uc338odi.1 
ENSMUST00000373016.1 ENSMUSG00000142742 ENSMUST00000373016.1 ENSMUSG00000142742 (from geneSymbol) uc338odm.1 uc338odm.1 
ENSMUST00000373018.1 ENSMUSG00000142743 ENSMUST00000373018.1 ENSMUSG00000142743 (from geneSymbol) uc338odo.1 uc338odo.1 
ENSMUST00000373025.1 ENSMUSG00000142744 ENSMUST00000373025.1 ENSMUSG00000142744 (from geneSymbol) uc338odv.1 uc338odv.1 
ENSMUST00000373056.1 ENSMUSG00000142745 ENSMUST00000373056.1 ENSMUSG00000142745 (from geneSymbol) uc338ofa.1 uc338ofa.1 
ENSMUST00000373061.1 ENSMUSG00000142746 ENSMUST00000373061.1 ENSMUSG00000142746 (from geneSymbol) uc338off.1 uc338off.1 
ENSMUST00000373062.1 Gm20163 ENSMUST00000373062.1 Gm20163 (from geneSymbol) uc338ofg.1 uc338ofg.1 
ENSMUST00000373069.1 ENSMUSG00000142747 ENSMUST00000373069.1 ENSMUSG00000142747 (from geneSymbol) uc338ofn.1 uc338ofn.1 
ENSMUST00000373070.1 ENSMUSG00000142748 ENSMUST00000373070.1 ENSMUSG00000142748 (from geneSymbol) uc338ofo.1 uc338ofo.1 
ENSMUST00000373071.1 ENSMUSG00000142749 ENSMUST00000373071.1 ENSMUSG00000142749 (from geneSymbol) uc338ofp.1 uc338ofp.1 
ENSMUST00000373072.1 ENSMUSG00000142750 ENSMUST00000373072.1 ENSMUSG00000142750 (from geneSymbol) uc338ofq.1 uc338ofq.1 
ENSMUST00000373074.1 ENSMUSG00000142751 ENSMUST00000373074.1 ENSMUSG00000142751 (from geneSymbol) uc338ofs.1 uc338ofs.1 
ENSMUST00000373075.1 ENSMUSG00000142752 ENSMUST00000373075.1 ENSMUSG00000142752 (from geneSymbol) DQ719359 uc338oft.1 uc338oft.1 
ENSMUST00000373079.1 Gm36539 ENSMUST00000373079.1 Gm36539 (from geneSymbol) uc338ofx.1 uc338ofx.1 
ENSMUST00000373093.1 ENSMUSG00000142753 ENSMUST00000373093.1 ENSMUSG00000142753 (from geneSymbol) uc338ogl.1 uc338ogl.1 
ENSMUST00000373097.1 Gm4208 ENSMUST00000373097.1 Gm4208 (from geneSymbol) BC048538 uc338ogp.1 uc338ogp.1 
ENSMUST00000373107.1 ENSMUSG00000142754 ENSMUST00000373107.1 ENSMUSG00000142754 (from geneSymbol) uc338ogz.1 uc338ogz.1 
ENSMUST00000373108.1 ENSMUSG00000142755 ENSMUST00000373108.1 ENSMUSG00000142755 (from geneSymbol) uc338oha.1 uc338oha.1 
ENSMUST00000373110.1 ENSMUSG00000142757 ENSMUST00000373110.1 ENSMUSG00000142757 (from geneSymbol) uc338ohb.1 uc338ohb.1 
ENSMUST00000373111.1 ENSMUSG00000142758 ENSMUST00000373111.1 ENSMUSG00000142758 (from geneSymbol) uc338ohc.1 uc338ohc.1 
ENSMUST00000373112.1 ENSMUSG00000142759 ENSMUST00000373112.1 ENSMUSG00000142759 (from geneSymbol) uc338ohd.1 uc338ohd.1 
ENSMUST00000373114.1 ENSMUSG00000142760 ENSMUST00000373114.1 ENSMUSG00000142760 (from geneSymbol) uc338ohf.1 uc338ohf.1 
ENSMUST00000373116.1 ENSMUSG00000142761 ENSMUST00000373116.1 ENSMUSG00000142761 (from geneSymbol) uc338ohh.1 uc338ohh.1 
ENSMUST00000373117.1 ENSMUSG00000142762 ENSMUST00000373117.1 ENSMUSG00000142762 (from geneSymbol) LF197413 uc338ohi.1 uc338ohi.1 
ENSMUST00000373118.1 ENSMUSG00000142763 ENSMUST00000373118.1 ENSMUSG00000142763 (from geneSymbol) uc338ohj.1 uc338ohj.1 
ENSMUST00000373119.1 ENSMUSG00000142764 ENSMUST00000373119.1 ENSMUSG00000142764 (from geneSymbol) uc338ohk.1 uc338ohk.1 
ENSMUST00000373124.1 ENSMUSG00000142765 ENSMUST00000373124.1 ENSMUSG00000142765 (from geneSymbol) uc338ohp.1 uc338ohp.1 
ENSMUST00000373129.1 ENSMUSG00000142766 ENSMUST00000373129.1 ENSMUSG00000142766 (from geneSymbol) uc338ohu.1 uc338ohu.1 
ENSMUST00000373132.1 ENSMUSG00000142767 ENSMUST00000373132.1 ENSMUSG00000142767 (from geneSymbol) uc338ohx.1 uc338ohx.1 
ENSMUST00000373133.1 ENSMUSG00000142768 ENSMUST00000373133.1 ENSMUSG00000142768 (from geneSymbol) uc338ohy.1 uc338ohy.1 
ENSMUST00000373139.1 Med9os ENSMUST00000373139.1 Med9os (from geneSymbol) KY467590 uc338oie.1 uc338oie.1 
ENSMUST00000373149.1 ENSMUSG00000142769 ENSMUST00000373149.1 ENSMUSG00000142769 (from geneSymbol) uc338oio.1 uc338oio.1 
ENSMUST00000373154.1 ENSMUSG00000142770 ENSMUST00000373154.1 ENSMUSG00000142770 (from geneSymbol) uc338oit.1 uc338oit.1 
ENSMUST00000373156.1 Gm35216 ENSMUST00000373156.1 Gm35216 (from geneSymbol) uc338oiv.1 uc338oiv.1 
ENSMUST00000373195.1 ENSMUSG00000142771 ENSMUST00000373195.1 ENSMUSG00000142771 (from geneSymbol) uc338oki.1 uc338oki.1 
ENSMUST00000373196.1 ENSMUSG00000142772 ENSMUST00000373196.1 ENSMUSG00000142772 (from geneSymbol) uc338okj.1 uc338okj.1 
ENSMUST00000373197.1 ENSMUSG00000142773 ENSMUST00000373197.1 ENSMUSG00000142773 (from geneSymbol) uc338okk.1 uc338okk.1 
ENSMUST00000373198.1 ENSMUSG00000142774 ENSMUST00000373198.1 ENSMUSG00000142774 (from geneSymbol) uc338okl.1 uc338okl.1 
ENSMUST00000373199.1 ENSMUSG00000142775 ENSMUST00000373199.1 ENSMUSG00000142775 (from geneSymbol) uc338okm.1 uc338okm.1 
ENSMUST00000373201.1 ENSMUSG00000142777 ENSMUST00000373201.1 ENSMUSG00000142777 (from geneSymbol) uc338okn.1 uc338okn.1 
ENSMUST00000373202.1 ENSMUSG00000142778 ENSMUST00000373202.1 ENSMUSG00000142778 (from geneSymbol) uc338oko.1 uc338oko.1 
ENSMUST00000373205.1 ENSMUSG00000142779 ENSMUST00000373205.1 ENSMUSG00000142779 (from geneSymbol) uc338okr.1 uc338okr.1 
ENSMUST00000373208.1 ENSMUSG00000142780 ENSMUST00000373208.1 ENSMUSG00000142780 (from geneSymbol) uc338oku.1 uc338oku.1 
ENSMUST00000373209.1 ENSMUSG00000142781 ENSMUST00000373209.1 ENSMUSG00000142781 (from geneSymbol) uc338okv.1 uc338okv.1 
ENSMUST00000373210.1 ENSMUSG00000142782 ENSMUST00000373210.1 ENSMUSG00000142782 (from geneSymbol) uc338okw.1 uc338okw.1 
ENSMUST00000373214.1 Gm32093 ENSMUST00000373214.1 Gm32093 (from geneSymbol) uc338ola.1 uc338ola.1 
ENSMUST00000373216.1 ENSMUSG00000142783 ENSMUST00000373216.1 ENSMUSG00000142783 (from geneSymbol) uc338olc.1 uc338olc.1 
ENSMUST00000373218.1 ENSMUSG00000142784 ENSMUST00000373218.1 ENSMUSG00000142784 (from geneSymbol) uc338ole.1 uc338ole.1 
ENSMUST00000373219.1 ENSMUSG00000142785 ENSMUST00000373219.1 ENSMUSG00000142785 (from geneSymbol) uc338olf.1 uc338olf.1 
ENSMUST00000373220.1 Gm56606 ENSMUST00000373220.1 Gm56606 (from geneSymbol) uc338olg.1 uc338olg.1 
ENSMUST00000373222.1 ENSMUSG00000142786 ENSMUST00000373222.1 ENSMUSG00000142786 (from geneSymbol) uc338oli.1 uc338oli.1 
ENSMUST00000373223.1 ENSMUSG00000142787 ENSMUST00000373223.1 ENSMUSG00000142787 (from geneSymbol) uc338olj.1 uc338olj.1 
ENSMUST00000373236.1 ENSMUSG00000142788 ENSMUST00000373236.1 ENSMUSG00000142788 (from geneSymbol) uc338olw.1 uc338olw.1 
ENSMUST00000373237.1 ENSMUSG00000142789 ENSMUST00000373237.1 ENSMUSG00000142789 (from geneSymbol) DQ717135 uc338olx.1 uc338olx.1 
ENSMUST00000373238.1 ENSMUSG00000142790 ENSMUST00000373238.1 ENSMUSG00000142790 (from geneSymbol) uc338oly.1 uc338oly.1 
ENSMUST00000373251.1 C230057M02Rik ENSMUST00000373251.1 C230057M02Rik (from geneSymbol) AK082503 uc338oml.1 uc338oml.1 
ENSMUST00000373253.1 ENSMUSG00000142791 ENSMUST00000373253.1 ENSMUSG00000142791 (from geneSymbol) uc338omn.1 uc338omn.1 
ENSMUST00000373255.1 ENSMUSG00000142792 ENSMUST00000373255.1 ENSMUSG00000142792 (from geneSymbol) uc338omp.1 uc338omp.1 
ENSMUST00000373258.1 ENSMUSG00000142793 ENSMUST00000373258.1 ENSMUSG00000142793 (from geneSymbol) uc338oms.1 uc338oms.1 
ENSMUST00000373259.1 ENSMUSG00000142794 ENSMUST00000373259.1 ENSMUSG00000142794 (from geneSymbol) uc338omt.1 uc338omt.1 
ENSMUST00000373260.1 ENSMUSG00000142795 ENSMUST00000373260.1 ENSMUSG00000142795 (from geneSymbol) uc338omu.1 uc338omu.1 
ENSMUST00000373263.1 ENSMUSG00000142796 ENSMUST00000373263.1 ENSMUSG00000142796 (from geneSymbol) uc338omx.1 uc338omx.1 
ENSMUST00000373264.1 ENSMUSG00000142797 ENSMUST00000373264.1 ENSMUSG00000142797 (from geneSymbol) uc338omy.1 uc338omy.1 
ENSMUST00000373268.1 Gm13266 ENSMUST00000373268.1 predicted gene 13266, transcript variant 8 (from RefSeq NR_166186.1) NR_166186 uc338onc.1 uc338onc.1 
ENSMUST00000373304.1 ENSMUSG00000142798 ENSMUST00000373304.1 ENSMUSG00000142798 (from geneSymbol) uc338oom.1 uc338oom.1 
ENSMUST00000373305.1 ENSMUSG00000142799 ENSMUST00000373305.1 ENSMUSG00000142799 (from geneSymbol) uc338oon.1 uc338oon.1 
ENSMUST00000373306.1 ENSMUSG00000142800 ENSMUST00000373306.1 ENSMUSG00000142800 (from geneSymbol) uc338ooo.1 uc338ooo.1 
ENSMUST00000373307.1 ENSMUSG00000142801 ENSMUST00000373307.1 ENSMUSG00000142801 (from geneSymbol) uc338oop.1 uc338oop.1 
ENSMUST00000373308.1 ENSMUSG00000142802 ENSMUST00000373308.1 ENSMUSG00000142802 (from geneSymbol) uc338ooq.1 uc338ooq.1 
ENSMUST00000373319.1 ENSMUSG00000142803 ENSMUST00000373319.1 ENSMUSG00000142803 (from geneSymbol) uc338opb.1 uc338opb.1 
ENSMUST00000373320.1 ENSMUSG00000142804 ENSMUST00000373320.1 ENSMUSG00000142804 (from geneSymbol) uc338opc.1 uc338opc.1 
ENSMUST00000373321.1 ENSMUSG00000142805 ENSMUST00000373321.1 ENSMUSG00000142805 (from geneSymbol) uc338opd.1 uc338opd.1 
ENSMUST00000373325.1 ENSMUSG00000142806 ENSMUST00000373325.1 ENSMUSG00000142806 (from geneSymbol) uc338oph.1 uc338oph.1 
ENSMUST00000373326.1 Gm48905 ENSMUST00000373326.1 Gm48905 (from geneSymbol) uc338opi.1 uc338opi.1 
ENSMUST00000373329.1 ENSMUSG00000142807 ENSMUST00000373329.1 ENSMUSG00000142807 (from geneSymbol) uc338opl.1 uc338opl.1 
ENSMUST00000373330.1 ENSMUSG00000142808 ENSMUST00000373330.1 ENSMUSG00000142808 (from geneSymbol) uc338opm.1 uc338opm.1 
ENSMUST00000373332.1 ENSMUSG00000142809 ENSMUST00000373332.1 ENSMUSG00000142809 (from geneSymbol) uc338opo.1 uc338opo.1 
ENSMUST00000373334.1 ENSMUSG00000142810 ENSMUST00000373334.1 ENSMUSG00000142810 (from geneSymbol) uc338opq.1 uc338opq.1 
ENSMUST00000373368.1 ENSMUSG00000142811 ENSMUST00000373368.1 ENSMUSG00000142811 (from geneSymbol) uc338oqy.1 uc338oqy.1 
ENSMUST00000373373.1 Gm32931 ENSMUST00000373373.1 Gm32931 (from geneSymbol) uc338ord.1 uc338ord.1 
ENSMUST00000373400.1 ENSMUSG00000142813 ENSMUST00000373400.1 ENSMUSG00000142813 (from geneSymbol) uc338ose.1 uc338ose.1 
ENSMUST00000373401.1 ENSMUSG00000142814 ENSMUST00000373401.1 ENSMUSG00000142814 (from geneSymbol) uc338osf.1 uc338osf.1 
ENSMUST00000373402.1 ENSMUSG00000142815 ENSMUST00000373402.1 ENSMUSG00000142815 (from geneSymbol) uc338osg.1 uc338osg.1 
ENSMUST00000373403.1 ENSMUSG00000142816 ENSMUST00000373403.1 ENSMUSG00000142816 (from geneSymbol) uc338osh.1 uc338osh.1 
ENSMUST00000373405.1 Gm10863 ENSMUST00000373405.1 Gm10863 (from geneSymbol) AK145218 uc338osj.1 uc338osj.1 
ENSMUST00000373426.1 ENSMUSG00000142818 ENSMUST00000373426.1 ENSMUSG00000142818 (from geneSymbol) uc338otc.1 uc338otc.1 
ENSMUST00000373427.1 ENSMUSG00000142819 ENSMUST00000373427.1 ENSMUSG00000142819 (from geneSymbol) uc338otd.1 uc338otd.1 
ENSMUST00000373428.1 ENSMUSG00000142820 ENSMUST00000373428.1 ENSMUSG00000142820 (from geneSymbol) uc338ote.1 uc338ote.1 
ENSMUST00000373429.1 ENSMUSG00000142821 ENSMUST00000373429.1 ENSMUSG00000142821 (from geneSymbol) AK002417 uc338otf.1 uc338otf.1 
ENSMUST00000373433.1 ENSMUSG00000142822 ENSMUST00000373433.1 ENSMUSG00000142822 (from geneSymbol) uc338otj.1 uc338otj.1 
ENSMUST00000373434.1 ENSMUSG00000142823 ENSMUST00000373434.1 ENSMUSG00000142823 (from geneSymbol) uc338otk.1 uc338otk.1 
ENSMUST00000373435.1 ENSMUSG00000142824 ENSMUST00000373435.1 ENSMUSG00000142824 (from geneSymbol) uc338otl.1 uc338otl.1 
ENSMUST00000373439.1 Gm27208 ENSMUST00000373439.1 Gm27208 (from geneSymbol) uc338otp.1 uc338otp.1 
ENSMUST00000373440.1 ENSMUSG00000142825 ENSMUST00000373440.1 ENSMUSG00000142825 (from geneSymbol) uc338otq.1 uc338otq.1 
ENSMUST00000373443.1 ENSMUSG00000142826 ENSMUST00000373443.1 ENSMUSG00000142826 (from geneSymbol) uc338ott.1 uc338ott.1 
ENSMUST00000373445.1 ENSMUSG00000142827 ENSMUST00000373445.1 ENSMUSG00000142827 (from geneSymbol) uc338otv.1 uc338otv.1 
ENSMUST00000373464.1 ENSMUSG00000142828 ENSMUST00000373464.1 ENSMUSG00000142828 (from geneSymbol) uc338ouo.1 uc338ouo.1 
ENSMUST00000373465.1 ENSMUSG00000142829 ENSMUST00000373465.1 ENSMUSG00000142829 (from geneSymbol) uc338oup.1 uc338oup.1 
ENSMUST00000373466.1 ENSMUSG00000142830 ENSMUST00000373466.1 ENSMUSG00000142830 (from geneSymbol) BC072647 uc338ouq.1 uc338ouq.1 
ENSMUST00000373468.1 ENSMUSG00000142831 ENSMUST00000373468.1 ENSMUSG00000142831 (from geneSymbol) uc338ous.1 uc338ous.1 
ENSMUST00000373470.1 ENSMUSG00000142832 ENSMUST00000373470.1 ENSMUSG00000142832 (from geneSymbol) uc338ouu.1 uc338ouu.1 
ENSMUST00000373476.1 ENSMUSG00000142833 ENSMUST00000373476.1 ENSMUSG00000142833 (from geneSymbol) uc338ova.1 uc338ova.1 
ENSMUST00000373478.1 ENSMUSG00000142834 ENSMUST00000373478.1 ENSMUSG00000142834 (from geneSymbol) uc338ovc.1 uc338ovc.1 
ENSMUST00000373480.1 Gm16192 ENSMUST00000373480.1 Gm16192 (from geneSymbol) AK158751 uc338ove.1 uc338ove.1 
ENSMUST00000373487.1 ENSMUSG00000142835 ENSMUST00000373487.1 ENSMUSG00000142835 (from geneSymbol) uc338ovl.1 uc338ovl.1 
ENSMUST00000373488.1 ENSMUSG00000142836 ENSMUST00000373488.1 ENSMUSG00000142836 (from geneSymbol) uc338ovm.1 uc338ovm.1 
ENSMUST00000373491.1 ENSMUSG00000142837 ENSMUST00000373491.1 ENSMUSG00000142837 (from geneSymbol) uc338ovp.1 uc338ovp.1 
ENSMUST00000373492.1 ENSMUSG00000142838 ENSMUST00000373492.1 ENSMUSG00000142838 (from geneSymbol) uc338ovq.1 uc338ovq.1 
ENSMUST00000373494.1 ENSMUSG00000142839 ENSMUST00000373494.1 ENSMUSG00000142839 (from geneSymbol) uc338ovs.1 uc338ovs.1 
ENSMUST00000373496.1 ENSMUSG00000142840 ENSMUST00000373496.1 ENSMUSG00000142840 (from geneSymbol) uc338ovu.1 uc338ovu.1 
ENSMUST00000373499.1 ENSMUSG00000142841 ENSMUST00000373499.1 ENSMUSG00000142841 (from geneSymbol) uc338ovx.1 uc338ovx.1 
ENSMUST00000373506.1 Gm57007 ENSMUST00000373506.1 Gm57007 (from geneSymbol) AK077682 uc338owe.1 uc338owe.1 
ENSMUST00000373512.1 Gm31749 ENSMUST00000373512.1 Gm31749 (from geneSymbol) uc338owk.1 uc338owk.1 
ENSMUST00000373514.1 ENSMUSG00000142842 ENSMUST00000373514.1 ENSMUSG00000142842 (from geneSymbol) uc338owm.1 uc338owm.1 
ENSMUST00000373515.1 ENSMUSG00000142843 ENSMUST00000373515.1 ENSMUSG00000142843 (from geneSymbol) uc338own.1 uc338own.1 
ENSMUST00000373516.1 Gm49135 ENSMUST00000373516.1 Gm49135 (from geneSymbol) AK047145 uc338owo.1 uc338owo.1 
ENSMUST00000373518.1 ENSMUSG00000142844 ENSMUST00000373518.1 ENSMUSG00000142844 (from geneSymbol) uc338owq.1 uc338owq.1 
ENSMUST00000373526.1 ENSMUSG00000142845 ENSMUST00000373526.1 ENSMUSG00000142845 (from geneSymbol) uc338owy.1 uc338owy.1 
ENSMUST00000373531.1 ENSMUSG00000142846 ENSMUST00000373531.1 ENSMUSG00000142846 (from geneSymbol) uc338oxd.1 uc338oxd.1 
ENSMUST00000373532.1 ENSMUSG00000142847 ENSMUST00000373532.1 ENSMUSG00000142847 (from geneSymbol) uc338oxe.1 uc338oxe.1 
ENSMUST00000373533.1 ENSMUSG00000142848 ENSMUST00000373533.1 ENSMUSG00000142848 (from geneSymbol) uc338oxf.1 uc338oxf.1 
ENSMUST00000373534.1 ENSMUSG00000142849 ENSMUST00000373534.1 ENSMUSG00000142849 (from geneSymbol) uc338oxg.1 uc338oxg.1 
ENSMUST00000373536.1 ENSMUSG00000142850 ENSMUST00000373536.1 ENSMUSG00000142850 (from geneSymbol) uc338oxi.1 uc338oxi.1 
ENSMUST00000373537.1 ENSMUSG00000142851 ENSMUST00000373537.1 ENSMUSG00000142851 (from geneSymbol) uc338oxj.1 uc338oxj.1 
ENSMUST00000373538.1 ENSMUSG00000142852 ENSMUST00000373538.1 ENSMUSG00000142852 (from geneSymbol) uc338oxk.1 uc338oxk.1 
ENSMUST00000373540.1 4930570D08Rik ENSMUST00000373540.1 4930570D08Rik (from geneSymbol) AK019796 uc338oxm.1 uc338oxm.1 
ENSMUST00000373555.1 ENSMUSG00000142853 ENSMUST00000373555.1 ENSMUSG00000142853 (from geneSymbol) uc338oyb.1 uc338oyb.1 
ENSMUST00000373556.1 ENSMUSG00000142854 ENSMUST00000373556.1 ENSMUSG00000142854 (from geneSymbol) uc338oyc.1 uc338oyc.1 
ENSMUST00000373561.1 ENSMUSG00000142855 ENSMUST00000373561.1 ENSMUSG00000142855 (from geneSymbol) uc338oyh.1 uc338oyh.1 
ENSMUST00000373562.1 ENSMUSG00000142856 ENSMUST00000373562.1 ENSMUSG00000142856 (from geneSymbol) uc338oyi.1 uc338oyi.1 
ENSMUST00000373565.1 ENSMUSG00000142857 ENSMUST00000373565.1 ENSMUSG00000142857 (from geneSymbol) uc338oyl.1 uc338oyl.1 
ENSMUST00000373566.1 ENSMUSG00000142858 ENSMUST00000373566.1 ENSMUSG00000142858 (from geneSymbol) uc338oym.1 uc338oym.1 
ENSMUST00000373567.1 ENSMUSG00000142859 ENSMUST00000373567.1 ENSMUSG00000142859 (from geneSymbol) uc338oyn.1 uc338oyn.1 
ENSMUST00000373569.1 ENSMUSG00000142860 ENSMUST00000373569.1 ENSMUSG00000142860 (from geneSymbol) uc338oyp.1 uc338oyp.1 
ENSMUST00000373570.1 ENSMUSG00000142861 ENSMUST00000373570.1 ENSMUSG00000142861 (from geneSymbol) uc338oyq.1 uc338oyq.1 
ENSMUST00000373571.1 ENSMUSG00000142862 ENSMUST00000373571.1 ENSMUSG00000142862 (from geneSymbol) uc338oyr.1 uc338oyr.1 
ENSMUST00000373574.1 ENSMUSG00000142863 ENSMUST00000373574.1 ENSMUSG00000142863 (from geneSymbol) uc338oyu.1 uc338oyu.1 
ENSMUST00000373583.1 ENSMUSG00000142864 ENSMUST00000373583.1 ENSMUSG00000142864 (from geneSymbol) uc338ozd.1 uc338ozd.1 
ENSMUST00000373585.1 Gm16499 ENSMUST00000373585.1 Gm16499 (from geneSymbol) AK039090 uc338ozf.1 uc338ozf.1 
ENSMUST00000373601.1 Gm33728 ENSMUST00000373601.1 Gm33728 (from geneSymbol) uc338ozv.1 uc338ozv.1 
ENSMUST00000373607.1 ENSMUSG00000142865 ENSMUST00000373607.1 ENSMUSG00000142865 (from geneSymbol) uc338pab.1 uc338pab.1 
ENSMUST00000373608.1 Gm47112 ENSMUST00000373608.1 Gm47112 (from geneSymbol) uc338pac.1 uc338pac.1 
ENSMUST00000373614.1 ENSMUSG00000142866 ENSMUST00000373614.1 ENSMUSG00000142866 (from geneSymbol) uc338pai.1 uc338pai.1 
ENSMUST00000373615.1 ENSMUSG00000142867 ENSMUST00000373615.1 ENSMUSG00000142867 (from geneSymbol) uc338paj.1 uc338paj.1 
ENSMUST00000373618.1 ENSMUSG00000142868 ENSMUST00000373618.1 ENSMUSG00000142868 (from geneSymbol) uc338pam.1 uc338pam.1 
ENSMUST00000373625.1 ENSMUSG00000142869 ENSMUST00000373625.1 ENSMUSG00000142869 (from geneSymbol) uc338pat.1 uc338pat.1 
ENSMUST00000373626.1 ENSMUSG00000142870 ENSMUST00000373626.1 ENSMUSG00000142870 (from geneSymbol) uc338pau.1 uc338pau.1 
ENSMUST00000373628.1 ENSMUSG00000142871 ENSMUST00000373628.1 ENSMUSG00000142871 (from geneSymbol) uc338paw.1 uc338paw.1 
ENSMUST00000373629.1 ENSMUSG00000142872 ENSMUST00000373629.1 ENSMUSG00000142872 (from geneSymbol) uc338pax.1 uc338pax.1 
ENSMUST00000373630.1 ENSMUSG00000142873 ENSMUST00000373630.1 ENSMUSG00000142873 (from geneSymbol) uc338pay.1 uc338pay.1 
ENSMUST00000373631.1 ENSMUSG00000142874 ENSMUST00000373631.1 ENSMUSG00000142874 (from geneSymbol) uc338paz.1 uc338paz.1 
ENSMUST00000373632.1 Gm46781 ENSMUST00000373632.1 Gm46781 (from geneSymbol) uc338pba.1 uc338pba.1 
ENSMUST00000373652.1 3100003L05Rik ENSMUST00000373652.1 3100003L05Rik (from geneSymbol) AK013926 uc338pbu.1 uc338pbu.1 
ENSMUST00000373668.1 ENSMUSG00000142875 ENSMUST00000373668.1 ENSMUSG00000142875 (from geneSymbol) uc338pck.1 uc338pck.1 
ENSMUST00000373683.1 ENSMUSG00000142876 ENSMUST00000373683.1 ENSMUSG00000142876 (from geneSymbol) uc338pcz.1 uc338pcz.1 
ENSMUST00000373685.1 ENSMUSG00000142877 ENSMUST00000373685.1 ENSMUSG00000142877 (from geneSymbol) uc338pdb.1 uc338pdb.1 
ENSMUST00000373687.1 ENSMUSG00000142878 ENSMUST00000373687.1 ENSMUSG00000142878 (from geneSymbol) uc338pdd.1 uc338pdd.1 
ENSMUST00000373688.1 ENSMUSG00000142879 ENSMUST00000373688.1 ENSMUSG00000142879 (from geneSymbol) uc338pde.1 uc338pde.1 
ENSMUST00000373689.1 ENSMUSG00000142880 ENSMUST00000373689.1 ENSMUSG00000142880 (from geneSymbol) uc338pdf.1 uc338pdf.1 
ENSMUST00000373697.1 ENSMUSG00000142881 ENSMUST00000373697.1 ENSMUSG00000142881 (from geneSymbol) uc338pdn.1 uc338pdn.1 
ENSMUST00000373698.1 ENSMUSG00000142882 ENSMUST00000373698.1 ENSMUSG00000142882 (from geneSymbol) uc338pdo.1 uc338pdo.1 
ENSMUST00000373707.1 ENSMUSG00000142883 ENSMUST00000373707.1 ENSMUSG00000142883 (from geneSymbol) uc338pdx.1 uc338pdx.1 
ENSMUST00000373708.1 ENSMUSG00000142884 ENSMUST00000373708.1 ENSMUSG00000142884 (from geneSymbol) uc338pdy.1 uc338pdy.1 
ENSMUST00000373712.1 ENSMUSG00000142885 ENSMUST00000373712.1 ENSMUSG00000142885 (from geneSymbol) uc338pec.1 uc338pec.1 
ENSMUST00000373716.1 ENSMUSG00000142886 ENSMUST00000373716.1 ENSMUSG00000142886 (from geneSymbol) uc338peg.1 uc338peg.1 
ENSMUST00000373717.1 ENSMUSG00000142887 ENSMUST00000373717.1 ENSMUSG00000142887 (from geneSymbol) uc338peh.1 uc338peh.1 
ENSMUST00000373718.1 ENSMUSG00000142888 ENSMUST00000373718.1 ENSMUSG00000142888 (from geneSymbol) uc338pei.1 uc338pei.1 
ENSMUST00000373719.1 ENSMUSG00000142889 ENSMUST00000373719.1 ENSMUSG00000142889 (from geneSymbol) uc338pej.1 uc338pej.1 
ENSMUST00000373724.1 ENSMUSG00000142890 ENSMUST00000373724.1 ENSMUSG00000142890 (from geneSymbol) uc338peo.1 uc338peo.1 
ENSMUST00000373726.1 ENSMUSG00000142891 ENSMUST00000373726.1 ENSMUSG00000142891 (from geneSymbol) uc338peq.1 uc338peq.1 
ENSMUST00000373727.1 Gm12714 ENSMUST00000373727.1 Gm12714 (from geneSymbol) uc338per.1 uc338per.1 
ENSMUST00000373728.1 ENSMUSG00000142892 ENSMUST00000373728.1 ENSMUSG00000142892 (from geneSymbol) uc338pes.1 uc338pes.1 
ENSMUST00000373736.1 ENSMUSG00000142893 ENSMUST00000373736.1 ENSMUSG00000142893 (from geneSymbol) LF194312 uc338pfa.1 uc338pfa.1 
ENSMUST00000373738.1 ENSMUSG00000142894 ENSMUST00000373738.1 ENSMUSG00000142894 (from geneSymbol) uc338pfc.1 uc338pfc.1 
ENSMUST00000373739.1 ENSMUSG00000142895 ENSMUST00000373739.1 ENSMUSG00000142895 (from geneSymbol) uc338pfd.1 uc338pfd.1 
ENSMUST00000373740.1 ENSMUSG00000142896 ENSMUST00000373740.1 ENSMUSG00000142896 (from geneSymbol) uc338pfe.1 uc338pfe.1 
ENSMUST00000373741.1 ENSMUSG00000142897 ENSMUST00000373741.1 ENSMUSG00000142897 (from geneSymbol) uc338pff.1 uc338pff.1 
ENSMUST00000373742.1 ENSMUSG00000142898 ENSMUST00000373742.1 ENSMUSG00000142898 (from geneSymbol) uc338pfg.1 uc338pfg.1 
ENSMUST00000373743.1 ENSMUSG00000142899 ENSMUST00000373743.1 ENSMUSG00000142899 (from geneSymbol) uc338pfh.1 uc338pfh.1 
ENSMUST00000373744.1 ENSMUSG00000142900 ENSMUST00000373744.1 ENSMUSG00000142900 (from geneSymbol) uc338pfi.1 uc338pfi.1 
ENSMUST00000373745.1 ENSMUSG00000142901 ENSMUST00000373745.1 ENSMUSG00000142901 (from geneSymbol) uc338pfj.1 uc338pfj.1 
ENSMUST00000373746.1 ENSMUSG00000142902 ENSMUST00000373746.1 ENSMUSG00000142902 (from geneSymbol) uc338pfk.1 uc338pfk.1 
ENSMUST00000373749.1 ENSMUSG00000142903 ENSMUST00000373749.1 ENSMUSG00000142903 (from geneSymbol) uc338pfn.1 uc338pfn.1 
ENSMUST00000373756.1 ENSMUSG00000142904 ENSMUST00000373756.1 ENSMUSG00000142904 (from geneSymbol) uc338pfu.1 uc338pfu.1 
ENSMUST00000373758.1 ENSMUSG00000142905 ENSMUST00000373758.1 ENSMUSG00000142905 (from geneSymbol) uc338pfw.1 uc338pfw.1 
ENSMUST00000373759.1 Appbp2os ENSMUST00000373759.1 Appbp2os (from geneSymbol) AK085477 uc338pfx.1 uc338pfx.1 
ENSMUST00000373764.1 ENSMUSG00000142906 ENSMUST00000373764.1 ENSMUSG00000142906 (from geneSymbol) AK015031 uc338pgc.1 uc338pgc.1 
ENSMUST00000373766.1 ENSMUSG00000142907 ENSMUST00000373766.1 ENSMUSG00000142907 (from geneSymbol) uc338pge.1 uc338pge.1 
ENSMUST00000373770.1 ENSMUSG00000142908 ENSMUST00000373770.1 ENSMUSG00000142908 (from geneSymbol) uc338pgi.1 uc338pgi.1 
ENSMUST00000373772.1 ENSMUSG00000142909 ENSMUST00000373772.1 ENSMUSG00000142909 (from geneSymbol) uc338pgk.1 uc338pgk.1 
ENSMUST00000373773.1 ENSMUSG00000142910 ENSMUST00000373773.1 ENSMUSG00000142910 (from geneSymbol) uc338pgl.1 uc338pgl.1 
ENSMUST00000373774.1 ENSMUSG00000142911 ENSMUST00000373774.1 ENSMUSG00000142911 (from geneSymbol) uc338pgm.1 uc338pgm.1 
ENSMUST00000373776.1 ENSMUSG00000142912 ENSMUST00000373776.1 ENSMUSG00000142912 (from geneSymbol) uc338pgo.1 uc338pgo.1 
ENSMUST00000373777.1 ENSMUSG00000142913 ENSMUST00000373777.1 ENSMUSG00000142913 (from geneSymbol) uc338pgp.1 uc338pgp.1 
ENSMUST00000373778.1 ENSMUSG00000142914 ENSMUST00000373778.1 ENSMUSG00000142914 (from geneSymbol) uc338pgq.1 uc338pgq.1 
ENSMUST00000373780.1 ENSMUSG00000142915 ENSMUST00000373780.1 ENSMUSG00000142915 (from geneSymbol) uc338pgs.1 uc338pgs.1 
ENSMUST00000373781.1 ENSMUSG00000142916 ENSMUST00000373781.1 ENSMUSG00000142916 (from geneSymbol) BC049991 uc338pgt.1 uc338pgt.1 
ENSMUST00000373789.1 ENSMUSG00000142917 ENSMUST00000373789.1 ENSMUSG00000142917 (from geneSymbol) uc338phb.1 uc338phb.1 
ENSMUST00000373790.1 ENSMUSG00000142918 ENSMUST00000373790.1 ENSMUSG00000142918 (from geneSymbol) uc338phc.1 uc338phc.1 
ENSMUST00000373792.1 ENSMUSG00000142919 ENSMUST00000373792.1 ENSMUSG00000142919 (from geneSymbol) uc338phe.1 uc338phe.1 
ENSMUST00000373805.1 ENSMUSG00000142920 ENSMUST00000373805.1 ENSMUSG00000142920 (from geneSymbol) uc338phr.1 uc338phr.1 
ENSMUST00000373807.1 ENSMUSG00000142921 ENSMUST00000373807.1 ENSMUSG00000142921 (from geneSymbol) uc338pht.1 uc338pht.1 
ENSMUST00000373811.1 ENSMUSG00000142922 ENSMUST00000373811.1 ENSMUSG00000142922 (from geneSymbol) uc338phx.1 uc338phx.1 
ENSMUST00000373820.1 ENSMUSG00000142923 ENSMUST00000373820.1 ENSMUSG00000142923 (from geneSymbol) uc338pig.1 uc338pig.1 
ENSMUST00000373823.1 ENSMUSG00000142924 ENSMUST00000373823.1 ENSMUSG00000142924 (from geneSymbol) uc338pij.1 uc338pij.1 
ENSMUST00000373827.1 Gm17473 ENSMUST00000373827.1 Gm17473 (from geneSymbol) uc338pin.1 uc338pin.1 
ENSMUST00000373831.1 ENSMUSG00000142925 ENSMUST00000373831.1 ENSMUSG00000142925 (from geneSymbol) uc338pir.1 uc338pir.1 
ENSMUST00000373832.1 ENSMUSG00000142926 ENSMUST00000373832.1 ENSMUSG00000142926 (from geneSymbol) uc338pis.1 uc338pis.1 
ENSMUST00000373833.1 Gm36536 ENSMUST00000373833.1 Gm36536 (from geneSymbol) AK158658 uc338pit.1 uc338pit.1 
ENSMUST00000373835.1 ENSMUSG00000142927 ENSMUST00000373835.1 ENSMUSG00000142927 (from geneSymbol) uc338piv.1 uc338piv.1 
ENSMUST00000373848.1 ENSMUSG00000142928 ENSMUST00000373848.1 ENSMUSG00000142928 (from geneSymbol) uc338pji.1 uc338pji.1 
ENSMUST00000373849.1 ENSMUSG00000142929 ENSMUST00000373849.1 ENSMUSG00000142929 (from geneSymbol) uc338pjj.1 uc338pjj.1 
ENSMUST00000373852.1 ENSMUSG00000142930 ENSMUST00000373852.1 ENSMUSG00000142930 (from geneSymbol) uc338pjm.1 uc338pjm.1 
ENSMUST00000373853.1 Gm27242 ENSMUST00000373853.1 Gm27242 (from geneSymbol) AK043960 uc338pjn.1 uc338pjn.1 
ENSMUST00000373870.1 ENSMUSG00000142931 ENSMUST00000373870.1 ENSMUSG00000142931 (from geneSymbol) uc338pke.1 uc338pke.1 
ENSMUST00000373871.1 ENSMUSG00000142932 ENSMUST00000373871.1 ENSMUSG00000142932 (from geneSymbol) uc338pkf.1 uc338pkf.1 
ENSMUST00000373876.1 ENSMUSG00000142933 ENSMUST00000373876.1 ENSMUSG00000142933 (from geneSymbol) uc338pkg.1 uc338pkg.1 
ENSMUST00000373882.1 ENSMUSG00000142934 ENSMUST00000373882.1 ENSMUSG00000142934 (from geneSymbol) uc338pkm.1 uc338pkm.1 
ENSMUST00000373884.1 ENSMUSG00000142935 ENSMUST00000373884.1 ENSMUSG00000142935 (from geneSymbol) uc338pko.1 uc338pko.1 
ENSMUST00000373885.1 ENSMUSG00000142936 ENSMUST00000373885.1 ENSMUSG00000142936 (from geneSymbol) uc338pkp.1 uc338pkp.1 
ENSMUST00000373886.1 ENSMUSG00000142937 ENSMUST00000373886.1 ENSMUSG00000142937 (from geneSymbol) uc338pkq.1 uc338pkq.1 
ENSMUST00000373888.1 ENSMUSG00000142938 ENSMUST00000373888.1 ENSMUSG00000142938 (from geneSymbol) uc338pks.1 uc338pks.1 
ENSMUST00000373889.1 ENSMUSG00000142939 ENSMUST00000373889.1 ENSMUSG00000142939 (from geneSymbol) uc338pkt.1 uc338pkt.1 
ENSMUST00000373894.1 ENSMUSG00000142940 ENSMUST00000373894.1 ENSMUSG00000142940 (from geneSymbol) uc338pky.1 uc338pky.1 
ENSMUST00000373895.1 ENSMUSG00000142941 ENSMUST00000373895.1 ENSMUSG00000142941 (from geneSymbol) LF195303 uc338pkz.1 uc338pkz.1 
ENSMUST00000373896.1 ENSMUSG00000142942 ENSMUST00000373896.1 ENSMUSG00000142942 (from geneSymbol) uc338pla.1 uc338pla.1 
ENSMUST00000373897.1 ENSMUSG00000142943 ENSMUST00000373897.1 ENSMUSG00000142943 (from geneSymbol) uc338plb.1 uc338plb.1 
ENSMUST00000373898.1 ENSMUSG00000142944 ENSMUST00000373898.1 ENSMUSG00000142944 (from geneSymbol) uc338plc.1 uc338plc.1 
ENSMUST00000373899.1 ENSMUSG00000142945 ENSMUST00000373899.1 ENSMUSG00000142945 (from geneSymbol) uc338pld.1 uc338pld.1 
ENSMUST00000373901.1 ENSMUSG00000142946 ENSMUST00000373901.1 ENSMUSG00000142946 (from geneSymbol) uc338plf.1 uc338plf.1 
ENSMUST00000373907.1 ENSMUSG00000142947 ENSMUST00000373907.1 ENSMUSG00000142947 (from geneSymbol) uc338pll.1 uc338pll.1 
ENSMUST00000373913.1 ENSMUSG00000142948 ENSMUST00000373913.1 ENSMUSG00000142948 (from geneSymbol) uc338plr.1 uc338plr.1 
ENSMUST00000373915.1 ENSMUSG00000142949 ENSMUST00000373915.1 ENSMUSG00000142949 (from geneSymbol) uc338plt.1 uc338plt.1 
ENSMUST00000373924.1 Gm28340 ENSMUST00000373924.1 Gm28340 (from geneSymbol) uc338pmc.1 uc338pmc.1 
ENSMUST00000373934.1 Gm12530 ENSMUST00000373934.1 Gm12530 (from geneSymbol) AK052790 uc338pmm.1 uc338pmm.1 
ENSMUST00000373941.1 Gm51802 ENSMUST00000373941.1 Gm51802 (from geneSymbol) uc338pmt.1 uc338pmt.1 
ENSMUST00000373945.1 ENSMUSG00000142950 ENSMUST00000373945.1 ENSMUSG00000142950 (from geneSymbol) uc338pmx.1 uc338pmx.1 
ENSMUST00000373950.1 ENSMUSG00000142951 ENSMUST00000373950.1 ENSMUSG00000142951 (from geneSymbol) uc338pnc.1 uc338pnc.1 
ENSMUST00000373951.1 Gm49145 ENSMUST00000373951.1 Gm49145 (from geneSymbol) uc338pnd.1 uc338pnd.1 
ENSMUST00000373960.1 ENSMUSG00000142952 ENSMUST00000373960.1 ENSMUSG00000142952 (from geneSymbol) uc338pnm.1 uc338pnm.1 
ENSMUST00000373961.1 ENSMUSG00000142953 ENSMUST00000373961.1 ENSMUSG00000142953 (from geneSymbol) uc338pnn.1 uc338pnn.1 
ENSMUST00000373964.1 ENSMUSG00000142954 ENSMUST00000373964.1 ENSMUSG00000142954 (from geneSymbol) uc338pnq.1 uc338pnq.1 
ENSMUST00000373966.1 Gm57063 ENSMUST00000373966.1 Gm57063 (from geneSymbol) uc338pns.1 uc338pns.1 
ENSMUST00000373972.1 ENSMUSG00000142955 ENSMUST00000373972.1 ENSMUSG00000142955 (from geneSymbol) uc338pny.1 uc338pny.1 
ENSMUST00000373973.1 ENSMUSG00000142956 ENSMUST00000373973.1 ENSMUSG00000142956 (from geneSymbol) uc338pnz.1 uc338pnz.1 
ENSMUST00000373975.1 ENSMUSG00000142957 ENSMUST00000373975.1 ENSMUSG00000142957 (from geneSymbol) uc338pob.1 uc338pob.1 
ENSMUST00000373976.1 ENSMUSG00000142958 ENSMUST00000373976.1 ENSMUSG00000142958 (from geneSymbol) uc338poc.1 uc338poc.1 
ENSMUST00000373988.1 ENSMUSG00000142959 ENSMUST00000373988.1 ENSMUSG00000142959 (from geneSymbol) uc338poo.1 uc338poo.1 
ENSMUST00000374007.1 ENSMUSG00000121500 ENSMUST00000374007.1 ENSMUSG00000121500 (from geneSymbol) uc338pph.1 uc338pph.1 
ENSMUST00000374062.1 ENSMUSG00000142960 ENSMUST00000374062.1 ENSMUSG00000142960 (from geneSymbol) uc338prj.1 uc338prj.1 
ENSMUST00000374063.1 ENSMUSG00000142961 ENSMUST00000374063.1 ENSMUSG00000142961 (from geneSymbol) AK048160 uc338prk.1 uc338prk.1 
ENSMUST00000374064.1 Gm10804 ENSMUST00000374064.1 Gm10804 (from geneSymbol) AK143789 uc338prl.1 uc338prl.1 
ENSMUST00000374068.1 ENSMUSG00000142962 ENSMUST00000374068.1 ENSMUSG00000142962 (from geneSymbol) uc338prp.1 uc338prp.1 
ENSMUST00000374070.1 Gm13470 ENSMUST00000374070.1 Gm13470 (from geneSymbol) uc338prr.1 uc338prr.1 
ENSMUST00000374090.1 ENSMUSG00000142963 ENSMUST00000374090.1 ENSMUSG00000142963 (from geneSymbol) uc338psl.1 uc338psl.1 
ENSMUST00000374104.1 Gm43357 ENSMUST00000374104.1 Gm43357 (from geneSymbol) AK005676 uc338psz.1 uc338psz.1 
ENSMUST00000374117.1 Gm40271 ENSMUST00000374117.1 Gm40271 (from geneSymbol) uc338ptm.1 uc338ptm.1 
ENSMUST00000374118.1 ENSMUSG00000142964 ENSMUST00000374118.1 ENSMUSG00000142964 (from geneSymbol) uc338ptn.1 uc338ptn.1 
ENSMUST00000374121.1 ENSMUSG00000142965 ENSMUST00000374121.1 ENSMUSG00000142965 (from geneSymbol) uc338ptq.1 uc338ptq.1 
ENSMUST00000374123.1 ENSMUSG00000142966 ENSMUST00000374123.1 ENSMUSG00000142966 (from geneSymbol) uc338pts.1 uc338pts.1 
ENSMUST00000374126.1 ENSMUSG00000142968 ENSMUST00000374126.1 ENSMUSG00000142968 (from geneSymbol) uc338ptt.1 uc338ptt.1 
ENSMUST00000374127.1 ENSMUSG00000142969 ENSMUST00000374127.1 ENSMUSG00000142969 (from geneSymbol) uc338ptu.1 uc338ptu.1 
ENSMUST00000374133.1 ENSMUSG00000142970 ENSMUST00000374133.1 ENSMUSG00000142970 (from geneSymbol) uc338pua.1 uc338pua.1 
ENSMUST00000374147.1 1810063I02Rik ENSMUST00000374147.1 1810063I02Rik (from geneSymbol) AK007947 uc338puo.1 uc338puo.1 
ENSMUST00000374150.1 ENSMUSG00000142972 ENSMUST00000374150.1 ENSMUSG00000142972 (from geneSymbol) uc338puq.1 uc338puq.1 
ENSMUST00000374151.1 ENSMUSG00000142973 ENSMUST00000374151.1 ENSMUSG00000142973 (from geneSymbol) uc338pur.1 uc338pur.1 
ENSMUST00000374152.1 ENSMUSG00000142974 ENSMUST00000374152.1 ENSMUSG00000142974 (from geneSymbol) uc338pus.1 uc338pus.1 
ENSMUST00000374175.1 Gm16344 ENSMUST00000374175.1 Gm16344 (from geneSymbol) AK146519 uc338pvp.1 uc338pvp.1 
ENSMUST00000374179.1 Gm31294 ENSMUST00000374179.1 Gm31294 (from geneSymbol) uc338pvt.1 uc338pvt.1 
ENSMUST00000374187.1 ENSMUSG00000142975 ENSMUST00000374187.1 ENSMUSG00000142975 (from geneSymbol) uc338pwb.1 uc338pwb.1 
ENSMUST00000374203.1 ENSMUSG00000142976 ENSMUST00000374203.1 ENSMUSG00000142976 (from geneSymbol) uc338pwr.1 uc338pwr.1 
ENSMUST00000374204.1 ENSMUSG00000142977 ENSMUST00000374204.1 ENSMUSG00000142977 (from geneSymbol) uc338pws.1 uc338pws.1 
ENSMUST00000374215.1 ENSMUSG00000142978 ENSMUST00000374215.1 ENSMUSG00000142978 (from geneSymbol) uc338pxd.1 uc338pxd.1 
ENSMUST00000374225.1 ENSMUSG00000142979 ENSMUST00000374225.1 ENSMUSG00000142979 (from geneSymbol) uc338pxn.1 uc338pxn.1 
ENSMUST00000374227.1 ENSMUSG00000142980 ENSMUST00000374227.1 ENSMUSG00000142980 (from geneSymbol) uc338pxp.1 uc338pxp.1 
ENSMUST00000374232.1 ENSMUSG00000142981 ENSMUST00000374232.1 ENSMUSG00000142981 (from geneSymbol) uc338pxu.1 uc338pxu.1 
ENSMUST00000374233.1 ENSMUSG00000142982 ENSMUST00000374233.1 ENSMUSG00000142982 (from geneSymbol) uc338pxv.1 uc338pxv.1 
ENSMUST00000374234.1 ENSMUSG00000142983 ENSMUST00000374234.1 ENSMUSG00000142983 (from geneSymbol) DQ694443 uc338pxw.1 uc338pxw.1 
ENSMUST00000374257.1 ENSMUSG00000142984 ENSMUST00000374257.1 ENSMUSG00000142984 (from geneSymbol) uc338pyt.1 uc338pyt.1 
ENSMUST00000374259.1 ENSMUSG00000142985 ENSMUST00000374259.1 ENSMUSG00000142985 (from geneSymbol) uc338pyv.1 uc338pyv.1 
ENSMUST00000374261.1 ENSMUSG00000142986 ENSMUST00000374261.1 ENSMUSG00000142986 (from geneSymbol) uc338pyx.1 uc338pyx.1 
ENSMUST00000374262.1 Gm12415 ENSMUST00000374262.1 predicted gene 12415 (from RefSeq NR_166699.1) NR_166699 uc338pyy.1 uc338pyy.1 
ENSMUST00000374263.1 Gm47916 ENSMUST00000374263.1 Gm47916 (from geneSymbol) uc338pyz.1 uc338pyz.1 
ENSMUST00000374264.1 Gm12801 ENSMUST00000374264.1 Gm12801 (from geneSymbol) uc338pza.1 uc338pza.1 
ENSMUST00000374266.1 ENSMUSG00000142987 ENSMUST00000374266.1 ENSMUSG00000142987 (from geneSymbol) uc338pzc.1 uc338pzc.1 
ENSMUST00000374267.1 Gm12031 ENSMUST00000374267.1 Gm12031 (from geneSymbol) uc338pzd.1 uc338pzd.1 
ENSMUST00000374274.1 ENSMUSG00000142988 ENSMUST00000374274.1 ENSMUSG00000142988 (from geneSymbol) uc338pzk.1 uc338pzk.1 
ENSMUST00000374276.1 ENSMUSG00000142990 ENSMUST00000374276.1 ENSMUSG00000142990 (from geneSymbol) uc338pzl.1 uc338pzl.1 
ENSMUST00000374277.1 ENSMUSG00000142991 ENSMUST00000374277.1 ENSMUSG00000142991 (from geneSymbol) uc338pzm.1 uc338pzm.1 
ENSMUST00000374278.1 ENSMUSG00000142992 ENSMUST00000374278.1 ENSMUSG00000142992 (from geneSymbol) uc338pzn.1 uc338pzn.1 
ENSMUST00000374280.1 ENSMUSG00000142993 ENSMUST00000374280.1 ENSMUSG00000142993 (from geneSymbol) uc338pzp.1 uc338pzp.1 
ENSMUST00000374284.1 ENSMUSG00000142994 ENSMUST00000374284.1 ENSMUSG00000142994 (from geneSymbol) uc338pzt.1 uc338pzt.1 
ENSMUST00000374286.1 ENSMUSG00000142995 ENSMUST00000374286.1 ENSMUSG00000142995 (from geneSymbol) uc338pzv.1 uc338pzv.1 
ENSMUST00000374288.1 ENSMUSG00000142996 ENSMUST00000374288.1 ENSMUSG00000142996 (from geneSymbol) uc338pzx.1 uc338pzx.1 
ENSMUST00000374296.1 Gm44442 ENSMUST00000374296.1 Gm44442 (from geneSymbol) uc338qaf.1 uc338qaf.1 
ENSMUST00000374327.1 ENSMUSG00000142997 ENSMUST00000374327.1 ENSMUSG00000142997 (from geneSymbol) uc338qbk.1 uc338qbk.1 
ENSMUST00000374329.1 ENSMUSG00000142998 ENSMUST00000374329.1 ENSMUSG00000142998 (from geneSymbol) uc338qbm.1 uc338qbm.1 
ENSMUST00000374330.1 ENSMUSG00000142999 ENSMUST00000374330.1 ENSMUSG00000142999 (from geneSymbol) uc338qbn.1 uc338qbn.1 
ENSMUST00000374332.1 ENSMUSG00000143000 ENSMUST00000374332.1 ENSMUSG00000143000 (from geneSymbol) uc338qbp.1 uc338qbp.1 
ENSMUST00000374334.1 Gm34157 ENSMUST00000374334.1 Gm34157 (from geneSymbol) uc338qbr.1 uc338qbr.1 
ENSMUST00000374341.1 Gm44020 ENSMUST00000374341.1 Gm44020 (from geneSymbol) uc338qby.1 uc338qby.1 
ENSMUST00000374347.1 1810058N15Rik ENSMUST00000374347.1 1810058N15Rik (from geneSymbol) uc338qce.1 uc338qce.1 
ENSMUST00000374350.1 ENSMUSG00000143001 ENSMUST00000374350.1 ENSMUSG00000143001 (from geneSymbol) uc338qch.1 uc338qch.1 
ENSMUST00000374351.1 ENSMUSG00000143002 ENSMUST00000374351.1 ENSMUSG00000143002 (from geneSymbol) uc338qci.1 uc338qci.1 
ENSMUST00000374353.1 ENSMUSG00000143003 ENSMUST00000374353.1 ENSMUSG00000143003 (from geneSymbol) uc338qck.1 uc338qck.1 
ENSMUST00000374355.1 ENSMUSG00000143004 ENSMUST00000374355.1 ENSMUSG00000143004 (from geneSymbol) uc338qcm.1 uc338qcm.1 
ENSMUST00000374356.1 ENSMUSG00000143005 ENSMUST00000374356.1 ENSMUSG00000143005 (from geneSymbol) uc338qcn.1 uc338qcn.1 
ENSMUST00000374357.1 ENSMUSG00000143006 ENSMUST00000374357.1 ENSMUSG00000143006 (from geneSymbol) uc338qco.1 uc338qco.1 
ENSMUST00000374359.1 ENSMUSG00000143007 ENSMUST00000374359.1 ENSMUSG00000143007 (from geneSymbol) uc338qcq.1 uc338qcq.1 
ENSMUST00000374360.1 ENSMUSG00000143008 ENSMUST00000374360.1 ENSMUSG00000143008 (from geneSymbol) uc338qcr.1 uc338qcr.1 
ENSMUST00000374361.1 ENSMUSG00000143009 ENSMUST00000374361.1 ENSMUSG00000143009 (from geneSymbol) uc338qcs.1 uc338qcs.1 
ENSMUST00000374369.1 A730085E03Rik ENSMUST00000374369.1 A730085E03Rik (from geneSymbol) AK080553 uc338qda.1 uc338qda.1 
ENSMUST00000374373.1 ENSMUSG00000143010 ENSMUST00000374373.1 ENSMUSG00000143010 (from geneSymbol) uc338qde.1 uc338qde.1 
ENSMUST00000374375.1 ENSMUSG00000143011 ENSMUST00000374375.1 ENSMUSG00000143011 (from geneSymbol) uc338qdg.1 uc338qdg.1 
ENSMUST00000374376.1 ENSMUSG00000143012 ENSMUST00000374376.1 ENSMUSG00000143012 (from geneSymbol) uc338qdh.1 uc338qdh.1 
ENSMUST00000374383.1 Gm26628 ENSMUST00000374383.1 Gm26628 (from geneSymbol) AK133081 uc338qdo.1 uc338qdo.1 
ENSMUST00000374385.1 ENSMUSG00000143013 ENSMUST00000374385.1 ENSMUSG00000143013 (from geneSymbol) uc338qdq.1 uc338qdq.1 
ENSMUST00000374386.1 ENSMUSG00000143014 ENSMUST00000374386.1 ENSMUSG00000143014 (from geneSymbol) uc338qdr.1 uc338qdr.1 
ENSMUST00000374387.1 ENSMUSG00000143015 ENSMUST00000374387.1 ENSMUSG00000143015 (from geneSymbol) uc338qds.1 uc338qds.1 
ENSMUST00000374388.1 ENSMUSG00000143016 ENSMUST00000374388.1 ENSMUSG00000143016 (from geneSymbol) uc338qdt.1 uc338qdt.1 
ENSMUST00000374390.1 ENSMUSG00000143017 ENSMUST00000374390.1 ENSMUSG00000143017 (from geneSymbol) uc338qdv.1 uc338qdv.1 
ENSMUST00000374398.1 ENSMUSG00000143018 ENSMUST00000374398.1 ENSMUSG00000143018 (from geneSymbol) uc338qed.1 uc338qed.1 
ENSMUST00000374401.1 ENSMUSG00000143019 ENSMUST00000374401.1 ENSMUSG00000143019 (from geneSymbol) uc338qeg.1 uc338qeg.1 
ENSMUST00000374406.1 ENSMUSG00000143020 ENSMUST00000374406.1 ENSMUSG00000143020 (from geneSymbol) uc338qel.1 uc338qel.1 
ENSMUST00000374407.1 ENSMUSG00000143021 ENSMUST00000374407.1 ENSMUSG00000143021 (from geneSymbol) uc338qem.1 uc338qem.1 
ENSMUST00000374408.1 ENSMUSG00000143022 ENSMUST00000374408.1 ENSMUSG00000143022 (from geneSymbol) uc338qen.1 uc338qen.1 
ENSMUST00000374422.1 ENSMUSG00000143023 ENSMUST00000374422.1 ENSMUSG00000143023 (from geneSymbol) uc338qfb.1 uc338qfb.1 
ENSMUST00000374424.1 ENSMUSG00000143024 ENSMUST00000374424.1 ENSMUSG00000143024 (from geneSymbol) uc338qfd.1 uc338qfd.1 
ENSMUST00000374426.1 Gm45092 ENSMUST00000374426.1 Gm45092 (from geneSymbol) uc338qff.1 uc338qff.1 
ENSMUST00000374430.1 Gm12796 ENSMUST00000374430.1 Gm12796 (from geneSymbol) KY468007 uc338qfj.1 uc338qfj.1 
ENSMUST00000374437.1 ENSMUSG00000143025 ENSMUST00000374437.1 ENSMUSG00000143025 (from geneSymbol) uc338qfq.1 uc338qfq.1 
ENSMUST00000374438.1 ENSMUSG00000143026 ENSMUST00000374438.1 ENSMUSG00000143026 (from geneSymbol) uc338qfr.1 uc338qfr.1 
ENSMUST00000374440.1 Gm47666 ENSMUST00000374440.1 Gm47666 (from geneSymbol) uc338qft.1 uc338qft.1 
ENSMUST00000374444.1 ENSMUSG00000143027 ENSMUST00000374444.1 ENSMUSG00000143027 (from geneSymbol) uc338qfx.1 uc338qfx.1 
ENSMUST00000374445.1 ENSMUSG00000143028 ENSMUST00000374445.1 ENSMUSG00000143028 (from geneSymbol) uc338qfy.1 uc338qfy.1 
ENSMUST00000374476.1 ENSMUSG00000143029 ENSMUST00000374476.1 ENSMUSG00000143029 (from geneSymbol) uc338qhd.1 uc338qhd.1 
ENSMUST00000374477.1 ENSMUSG00000143030 ENSMUST00000374477.1 ENSMUSG00000143030 (from geneSymbol) uc338qhe.1 uc338qhe.1 
ENSMUST00000374481.1 ENSMUSG00000143032 ENSMUST00000374481.1 ENSMUSG00000143032 (from geneSymbol) uc338qhh.1 uc338qhh.1 
ENSMUST00000374482.1 ENSMUSG00000143033 ENSMUST00000374482.1 ENSMUSG00000143033 (from geneSymbol) AK006399 uc338qhi.1 uc338qhi.1 
ENSMUST00000374483.1 ENSMUSG00000143034 ENSMUST00000374483.1 ENSMUSG00000143034 (from geneSymbol) uc338qhj.1 uc338qhj.1 
ENSMUST00000374488.1 Gm31545 ENSMUST00000374488.1 Gm31545 (from geneSymbol) uc338qho.1 uc338qho.1 
ENSMUST00000374490.1 ENSMUSG00000143035 ENSMUST00000374490.1 ENSMUSG00000143035 (from geneSymbol) uc338qhq.1 uc338qhq.1 
ENSMUST00000374493.1 ENSMUSG00000143036 ENSMUST00000374493.1 ENSMUSG00000143036 (from geneSymbol) uc338qht.1 uc338qht.1 
ENSMUST00000374522.1 ENSMUSG00000143038 ENSMUST00000374522.1 ENSMUSG00000143038 (from geneSymbol) uc338qia.1 uc338qia.1 
ENSMUST00000374541.1 ENSMUSG00000143039 ENSMUST00000374541.1 ENSMUSG00000143039 (from geneSymbol) uc338qit.1 uc338qit.1 
ENSMUST00000374542.1 ENSMUSG00000143040 ENSMUST00000374542.1 ENSMUSG00000143040 (from geneSymbol) uc338qiu.1 uc338qiu.1 
ENSMUST00000374543.1 ENSMUSG00000143041 ENSMUST00000374543.1 ENSMUSG00000143041 (from geneSymbol) uc338qiv.1 uc338qiv.1 
ENSMUST00000374546.1 ENSMUSG00000143042 ENSMUST00000374546.1 ENSMUSG00000143042 (from geneSymbol) uc338qiy.1 uc338qiy.1 
ENSMUST00000374554.1 ENSMUSG00000143043 ENSMUST00000374554.1 ENSMUSG00000143043 (from geneSymbol) uc338qjg.1 uc338qjg.1 
ENSMUST00000374560.1 Gm16213 ENSMUST00000374560.1 Gm16213 (from geneSymbol) uc338qji.1 uc338qji.1 
ENSMUST00000374571.1 ENSMUSG00000143044 ENSMUST00000374571.1 ENSMUSG00000143044 (from geneSymbol) uc338qjs.1 uc338qjs.1 
ENSMUST00000374576.1 ENSMUSG00000143046 ENSMUST00000374576.1 ENSMUSG00000143046 (from geneSymbol) uc338qjw.1 uc338qjw.1 
ENSMUST00000374578.1 ENSMUSG00000143047 ENSMUST00000374578.1 ENSMUSG00000143047 (from geneSymbol) uc338qjy.1 uc338qjy.1 
ENSMUST00000374582.1 ENSMUSG00000143048 ENSMUST00000374582.1 ENSMUSG00000143048 (from geneSymbol) uc338qkc.1 uc338qkc.1 
ENSMUST00000374583.1 ENSMUSG00000143049 ENSMUST00000374583.1 ENSMUSG00000143049 (from geneSymbol) uc338qkd.1 uc338qkd.1 
ENSMUST00000374584.1 ENSMUSG00000143050 ENSMUST00000374584.1 ENSMUSG00000143050 (from geneSymbol) uc338qke.1 uc338qke.1 
ENSMUST00000374587.1 ENSMUSG00000143051 ENSMUST00000374587.1 ENSMUSG00000143051 (from geneSymbol) uc338qkh.1 uc338qkh.1 
ENSMUST00000374588.1 ENSMUSG00000143052 ENSMUST00000374588.1 ENSMUSG00000143052 (from geneSymbol) LF192762 uc338qki.1 uc338qki.1 
ENSMUST00000374589.1 ENSMUSG00000143053 ENSMUST00000374589.1 ENSMUSG00000143053 (from geneSymbol) uc338qkj.1 uc338qkj.1 
ENSMUST00000374590.1 ENSMUSG00000143054 ENSMUST00000374590.1 ENSMUSG00000143054 (from geneSymbol) uc338qkk.1 uc338qkk.1 
ENSMUST00000374592.1 ENSMUSG00000143055 ENSMUST00000374592.1 ENSMUSG00000143055 (from geneSymbol) uc338qkl.1 uc338qkl.1 
ENSMUST00000374594.1 ENSMUSG00000143056 ENSMUST00000374594.1 ENSMUSG00000143056 (from geneSymbol) uc338qkm.1 uc338qkm.1 
ENSMUST00000374596.1 Gm45368 ENSMUST00000374596.1 Gm45368 (from geneSymbol) uc338qko.1 uc338qko.1 
ENSMUST00000374602.1 ENSMUSG00000143057 ENSMUST00000374602.1 ENSMUSG00000143057 (from geneSymbol) uc338qku.1 uc338qku.1 
ENSMUST00000374603.1 ENSMUSG00000143058 ENSMUST00000374603.1 ENSMUSG00000143058 (from geneSymbol) uc338qkv.1 uc338qkv.1 
ENSMUST00000374607.1 Sox1ot ENSMUST00000374607.1 Sox1ot (from geneSymbol) BC066076 uc338qky.1 uc338qky.1 
ENSMUST00000374640.1 ENSMUSG00000143059 ENSMUST00000374640.1 ENSMUSG00000143059 (from geneSymbol) uc338qme.1 uc338qme.1 
ENSMUST00000374641.1 ENSMUSG00000143060 ENSMUST00000374641.1 ENSMUSG00000143060 (from geneSymbol) uc338qmf.1 uc338qmf.1 
ENSMUST00000374644.1 Gm12694 ENSMUST00000374644.1 Gm12694 (from geneSymbol) uc338qmi.1 uc338qmi.1 
ENSMUST00000374645.1 ENSMUSG00000143061 ENSMUST00000374645.1 ENSMUSG00000143061 (from geneSymbol) uc338qmj.1 uc338qmj.1 
ENSMUST00000374647.1 Gm47343 ENSMUST00000374647.1 Gm47343 (from geneSymbol) uc338qml.1 uc338qml.1 
ENSMUST00000374649.1 ENSMUSG00000143062 ENSMUST00000374649.1 ENSMUSG00000143062 (from geneSymbol) LF203685 uc338qmn.1 uc338qmn.1 
ENSMUST00000374653.1 ENSMUSG00000143063 ENSMUST00000374653.1 ENSMUSG00000143063 (from geneSymbol) uc338qmr.1 uc338qmr.1 
ENSMUST00000374655.1 ENSMUSG00000143064 ENSMUST00000374655.1 ENSMUSG00000143064 (from geneSymbol) uc338qmt.1 uc338qmt.1 
ENSMUST00000374656.1 ENSMUSG00000143065 ENSMUST00000374656.1 ENSMUSG00000143065 (from geneSymbol) uc338qmu.1 uc338qmu.1 
ENSMUST00000374658.1 ENSMUSG00000143066 ENSMUST00000374658.1 ENSMUSG00000143066 (from geneSymbol) uc338qmw.1 uc338qmw.1 
ENSMUST00000374659.1 ENSMUSG00000143067 ENSMUST00000374659.1 ENSMUSG00000143067 (from geneSymbol) uc338qmx.1 uc338qmx.1 
ENSMUST00000374660.1 ENSMUSG00000143068 ENSMUST00000374660.1 ENSMUSG00000143068 (from geneSymbol) uc338qmy.1 uc338qmy.1 
ENSMUST00000374667.1 ENSMUSG00000143069 ENSMUST00000374667.1 ENSMUSG00000143069 (from geneSymbol) uc338qnf.1 uc338qnf.1 
ENSMUST00000374671.1 ENSMUSG00000143070 ENSMUST00000374671.1 ENSMUSG00000143070 (from geneSymbol) uc338qnj.1 uc338qnj.1 
ENSMUST00000374672.1 1700013M08Rik ENSMUST00000374672.1 1700013M08Rik (from geneSymbol) uc338qnk.1 uc338qnk.1 
ENSMUST00000374673.1 ENSMUSG00000143071 ENSMUST00000374673.1 ENSMUSG00000143071 (from geneSymbol) uc338qnl.1 uc338qnl.1 
ENSMUST00000374674.1 ENSMUSG00000143072 ENSMUST00000374674.1 ENSMUSG00000143072 (from geneSymbol) AK042466 uc338qnm.1 uc338qnm.1 
ENSMUST00000374675.1 D030007L05Rik ENSMUST00000374675.1 D030007L05Rik (from geneSymbol) AK083430 uc338qnn.1 uc338qnn.1 
ENSMUST00000374677.1 ENSMUSG00000143073 ENSMUST00000374677.1 ENSMUSG00000143073 (from geneSymbol) uc338qnp.1 uc338qnp.1 
ENSMUST00000374678.1 Gm27230 ENSMUST00000374678.1 Gm27230 (from geneSymbol) AK040357 uc338qnq.1 uc338qnq.1 
ENSMUST00000374691.1 ENSMUSG00000143074 ENSMUST00000374691.1 ENSMUSG00000143074 (from geneSymbol) uc338qod.1 uc338qod.1 
ENSMUST00000374692.1 ENSMUSG00000143075 ENSMUST00000374692.1 ENSMUSG00000143075 (from geneSymbol) uc338qoe.1 uc338qoe.1 
ENSMUST00000374693.1 ENSMUSG00000143076 ENSMUST00000374693.1 ENSMUSG00000143076 (from geneSymbol) uc338qof.1 uc338qof.1 
ENSMUST00000374694.1 ENSMUSG00000143077 ENSMUST00000374694.1 ENSMUSG00000143077 (from geneSymbol) uc338qog.1 uc338qog.1 
ENSMUST00000374696.1 Gm56491 ENSMUST00000374696.1 Gm56491 (from geneSymbol) uc338qoi.1 uc338qoi.1 
ENSMUST00000374703.1 ENSMUSG00000143078 ENSMUST00000374703.1 ENSMUSG00000143078 (from geneSymbol) uc338qop.1 uc338qop.1 
ENSMUST00000374714.1 ENSMUSG00000143079 ENSMUST00000374714.1 ENSMUSG00000143079 (from geneSymbol) uc338qpa.1 uc338qpa.1 
ENSMUST00000374715.1 Gm34593 ENSMUST00000374715.1 Gm34593 (from geneSymbol) uc338qpb.1 uc338qpb.1 
ENSMUST00000374717.1 ENSMUSG00000143081 ENSMUST00000374717.1 ENSMUSG00000143081 (from geneSymbol) uc338qpd.1 uc338qpd.1 
ENSMUST00000374719.1 ENSMUSG00000143082 ENSMUST00000374719.1 ENSMUSG00000143082 (from geneSymbol) uc338qpf.1 uc338qpf.1 
ENSMUST00000374721.1 ENSMUSG00000143083 ENSMUST00000374721.1 ENSMUSG00000143083 (from geneSymbol) uc338qph.1 uc338qph.1 
ENSMUST00000374722.1 ENSMUSG00000143084 ENSMUST00000374722.1 ENSMUSG00000143084 (from geneSymbol) uc338qpi.1 uc338qpi.1 
ENSMUST00000374724.1 ENSMUSG00000143085 ENSMUST00000374724.1 ENSMUSG00000143085 (from geneSymbol) uc338qpj.1 uc338qpj.1 
ENSMUST00000374725.1 ENSMUSG00000143086 ENSMUST00000374725.1 ENSMUSG00000143086 (from geneSymbol) AK164250 uc338qpk.1 uc338qpk.1 
ENSMUST00000374728.1 Gm20670 ENSMUST00000374728.1 Gm20670 (from geneSymbol) uc338qpn.1 uc338qpn.1 
ENSMUST00000374749.1 ENSMUSG00000143087 ENSMUST00000374749.1 ENSMUSG00000143087 (from geneSymbol) AK085986 uc338qqi.1 uc338qqi.1 
ENSMUST00000374756.1 ENSMUSG00000143088 ENSMUST00000374756.1 ENSMUSG00000143088 (from geneSymbol) uc338qqp.1 uc338qqp.1 
ENSMUST00000374757.1 ENSMUSG00000143089 ENSMUST00000374757.1 ENSMUSG00000143089 (from geneSymbol) uc338qqq.1 uc338qqq.1 
ENSMUST00000374759.1 ENSMUSG00000143090 ENSMUST00000374759.1 ENSMUSG00000143090 (from geneSymbol) uc338qqs.1 uc338qqs.1 
ENSMUST00000374760.1 ENSMUSG00000143091 ENSMUST00000374760.1 ENSMUSG00000143091 (from geneSymbol) uc338qqt.1 uc338qqt.1 
ENSMUST00000374761.1 ENSMUSG00000143092 ENSMUST00000374761.1 ENSMUSG00000143092 (from geneSymbol) uc338qqu.1 uc338qqu.1 
ENSMUST00000374762.1 ENSMUSG00000143093 ENSMUST00000374762.1 ENSMUSG00000143093 (from geneSymbol) uc338qqv.1 uc338qqv.1 
ENSMUST00000374764.1 ENSMUSG00000143094 ENSMUST00000374764.1 ENSMUSG00000143094 (from geneSymbol) uc338qqx.1 uc338qqx.1 
ENSMUST00000374768.1 ENSMUSG00000143095 ENSMUST00000374768.1 ENSMUSG00000143095 (from geneSymbol) uc338qrb.1 uc338qrb.1 
ENSMUST00000374785.1 ENSMUSG00000143096 ENSMUST00000374785.1 ENSMUSG00000143096 (from geneSymbol) uc338qrs.1 uc338qrs.1 
ENSMUST00000374786.1 ENSMUSG00000143097 ENSMUST00000374786.1 ENSMUSG00000143097 (from geneSymbol) uc338qrt.1 uc338qrt.1 
ENSMUST00000374789.1 ENSMUSG00000143098 ENSMUST00000374789.1 ENSMUSG00000143098 (from geneSymbol) uc338qrw.1 uc338qrw.1 
ENSMUST00000374792.1 ENSMUSG00000143100 ENSMUST00000374792.1 ENSMUSG00000143100 (from geneSymbol) uc338qry.1 uc338qry.1 
ENSMUST00000374795.1 ENSMUSG00000143101 ENSMUST00000374795.1 ENSMUSG00000143101 (from geneSymbol) uc338qsb.1 uc338qsb.1 
ENSMUST00000374797.1 ENSMUSG00000143102 ENSMUST00000374797.1 ENSMUSG00000143102 (from geneSymbol) uc338qsd.1 uc338qsd.1 
ENSMUST00000374801.1 Gm12678 ENSMUST00000374801.1 Gm12678 (from geneSymbol) KY467975 uc338qse.1 uc338qse.1 
ENSMUST00000374805.1 ENSMUSG00000143104 ENSMUST00000374805.1 ENSMUSG00000143104 (from geneSymbol) uc338qsi.1 uc338qsi.1 
ENSMUST00000374806.1 ENSMUSG00000143105 ENSMUST00000374806.1 ENSMUSG00000143105 (from geneSymbol) uc338qsj.1 uc338qsj.1 
ENSMUST00000374811.1 ENSMUSG00000143106 ENSMUST00000374811.1 ENSMUSG00000143106 (from geneSymbol) uc338qso.1 uc338qso.1 
ENSMUST00000374813.1 ENSMUSG00000143107 ENSMUST00000374813.1 ENSMUSG00000143107 (from geneSymbol) uc338qsq.1 uc338qsq.1 
ENSMUST00000374816.1 ENSMUSG00000143108 ENSMUST00000374816.1 ENSMUSG00000143108 (from geneSymbol) uc338qst.1 uc338qst.1 
ENSMUST00000374818.1 1700025K04Rik ENSMUST00000374818.1 1700025K04Rik (from geneSymbol) AK006351 uc338qsv.1 uc338qsv.1 
ENSMUST00000374822.1 ENSMUSG00000143109 ENSMUST00000374822.1 ENSMUSG00000143109 (from geneSymbol) uc338qsz.1 uc338qsz.1 
ENSMUST00000374830.1 ENSMUSG00000143110 ENSMUST00000374830.1 ENSMUSG00000143110 (from geneSymbol) uc338qth.1 uc338qth.1 
ENSMUST00000374834.1 ENSMUSG00000143111 ENSMUST00000374834.1 ENSMUSG00000143111 (from geneSymbol) uc338qtl.1 uc338qtl.1 
ENSMUST00000374841.1 Gm46565 ENSMUST00000374841.1 Gm46565 (from geneSymbol) uc338qts.1 uc338qts.1 
ENSMUST00000374881.1 ENSMUSG00000143112 ENSMUST00000374881.1 ENSMUSG00000143112 (from geneSymbol) uc338qvg.1 uc338qvg.1 
ENSMUST00000374886.1 ENSMUSG00000143113 ENSMUST00000374886.1 ENSMUSG00000143113 (from geneSymbol) uc338qvl.1 uc338qvl.1 
ENSMUST00000374890.1 ENSMUSG00000143114 ENSMUST00000374890.1 ENSMUSG00000143114 (from geneSymbol) uc338qvp.1 uc338qvp.1 
ENSMUST00000374893.1 ENSMUSG00000143115 ENSMUST00000374893.1 ENSMUSG00000143115 (from geneSymbol) uc338qvs.1 uc338qvs.1 
ENSMUST00000374907.1 ENSMUSG00000143116 ENSMUST00000374907.1 ENSMUSG00000143116 (from geneSymbol) uc338qwg.1 uc338qwg.1 
ENSMUST00000374908.1 ENSMUSG00000143117 ENSMUST00000374908.1 ENSMUSG00000143117 (from geneSymbol) uc338qwh.1 uc338qwh.1 
ENSMUST00000374909.1 ENSMUSG00000143118 ENSMUST00000374909.1 ENSMUSG00000143118 (from geneSymbol) uc338qwi.1 uc338qwi.1 
ENSMUST00000374920.1 ENSMUSG00000143119 ENSMUST00000374920.1 ENSMUSG00000143119 (from geneSymbol) uc338qwt.1 uc338qwt.1 
ENSMUST00000374921.1 ENSMUSG00000143120 ENSMUST00000374921.1 ENSMUSG00000143120 (from geneSymbol) uc338qwu.1 uc338qwu.1 
ENSMUST00000374922.1 ENSMUSG00000143121 ENSMUST00000374922.1 ENSMUSG00000143121 (from geneSymbol) uc338qwv.1 uc338qwv.1 
ENSMUST00000374924.1 ENSMUSG00000143122 ENSMUST00000374924.1 ENSMUSG00000143122 (from geneSymbol) uc338qwx.1 uc338qwx.1 
ENSMUST00000374926.1 ENSMUSG00000143123 ENSMUST00000374926.1 ENSMUSG00000143123 (from geneSymbol) uc338qwz.1 uc338qwz.1 
ENSMUST00000374927.1 Gm2093 ENSMUST00000374927.1 Gm2093 (from geneSymbol) AK041537 uc338qxa.1 uc338qxa.1 
ENSMUST00000374941.1 ENSMUSG00000143124 ENSMUST00000374941.1 ENSMUSG00000143124 (from geneSymbol) uc338qxo.1 uc338qxo.1 
ENSMUST00000374946.1 ENSMUSG00000143125 ENSMUST00000374946.1 ENSMUSG00000143125 (from geneSymbol) uc338qxt.1 uc338qxt.1 
ENSMUST00000374947.1 ENSMUSG00000143126 ENSMUST00000374947.1 ENSMUSG00000143126 (from geneSymbol) uc338qxu.1 uc338qxu.1 
ENSMUST00000374948.1 ENSMUSG00000143127 ENSMUST00000374948.1 ENSMUSG00000143127 (from geneSymbol) uc338qxv.1 uc338qxv.1 
ENSMUST00000374949.1 ENSMUSG00000143128 ENSMUST00000374949.1 ENSMUSG00000143128 (from geneSymbol) uc338qxw.1 uc338qxw.1 
ENSMUST00000374952.1 Gm36766 ENSMUST00000374952.1 Gm36766 (from geneSymbol) uc338qxz.1 uc338qxz.1 
ENSMUST00000374972.1 ENSMUSG00000143130 ENSMUST00000374972.1 ENSMUSG00000143130 (from geneSymbol) uc338qyt.1 uc338qyt.1 
ENSMUST00000374975.1 ENSMUSG00000143131 ENSMUST00000374975.1 ENSMUSG00000143131 (from geneSymbol) uc338qyw.1 uc338qyw.1 
ENSMUST00000374979.1 ENSMUSG00000143132 ENSMUST00000374979.1 ENSMUSG00000143132 (from geneSymbol) uc338qza.1 uc338qza.1 
ENSMUST00000374980.1 ENSMUSG00000143133 ENSMUST00000374980.1 ENSMUSG00000143133 (from geneSymbol) uc338qzb.1 uc338qzb.1 
ENSMUST00000374981.1 ENSMUSG00000143134 ENSMUST00000374981.1 ENSMUSG00000143134 (from geneSymbol) uc338qzc.1 uc338qzc.1 
ENSMUST00000374982.1 ENSMUSG00000143135 ENSMUST00000374982.1 ENSMUSG00000143135 (from geneSymbol) uc338qzd.1 uc338qzd.1 
ENSMUST00000374984.1 Gm5646 ENSMUST00000374984.1 Gm5646 (from geneSymbol) uc338qzf.1 uc338qzf.1 
ENSMUST00000374986.1 ENSMUSG00000143137 ENSMUST00000374986.1 ENSMUSG00000143137 (from geneSymbol) uc338qzh.1 uc338qzh.1 
ENSMUST00000374991.1 ENSMUSG00000143138 ENSMUST00000374991.1 ENSMUSG00000143138 (from geneSymbol) uc338qzm.1 uc338qzm.1 
ENSMUST00000375000.1 ENSMUSG00000143139 ENSMUST00000375000.1 ENSMUSG00000143139 (from geneSymbol) DQ545604 uc338qzv.1 uc338qzv.1 
ENSMUST00000375002.1 ENSMUSG00000143140 ENSMUST00000375002.1 ENSMUSG00000143140 (from geneSymbol) uc338qzw.1 uc338qzw.1 
ENSMUST00000375004.1 ENSMUSG00000143141 ENSMUST00000375004.1 ENSMUSG00000143141 (from geneSymbol) uc338qzy.1 uc338qzy.1 
ENSMUST00000375005.1 ENSMUSG00000143142 ENSMUST00000375005.1 ENSMUSG00000143142 (from geneSymbol) uc338qzz.1 uc338qzz.1 
ENSMUST00000375006.1 ENSMUSG00000143143 ENSMUST00000375006.1 ENSMUSG00000143143 (from geneSymbol) uc338raa.1 uc338raa.1 
ENSMUST00000375007.1 ENSMUSG00000143144 ENSMUST00000375007.1 ENSMUSG00000143144 (from geneSymbol) uc338rab.1 uc338rab.1 
ENSMUST00000375008.1 ENSMUSG00000143145 ENSMUST00000375008.1 ENSMUSG00000143145 (from geneSymbol) uc338rac.1 uc338rac.1 
ENSMUST00000375011.1 ENSMUSG00000143146 ENSMUST00000375011.1 ENSMUSG00000143146 (from geneSymbol) uc338raf.1 uc338raf.1 
ENSMUST00000375013.1 E330020D12Rik ENSMUST00000375013.1 E330020D12Rik (from geneSymbol) uc338rah.1 uc338rah.1 
ENSMUST00000375021.1 ENSMUSG00000143147 ENSMUST00000375021.1 ENSMUSG00000143147 (from geneSymbol) uc338rap.1 uc338rap.1 
ENSMUST00000375022.1 ENSMUSG00000143148 ENSMUST00000375022.1 ENSMUSG00000143148 (from geneSymbol) uc338raq.1 uc338raq.1 
ENSMUST00000375023.1 ENSMUSG00000143149 ENSMUST00000375023.1 ENSMUSG00000143149 (from geneSymbol) uc338rar.1 uc338rar.1 
ENSMUST00000375024.1 ENSMUSG00000143150 ENSMUST00000375024.1 ENSMUSG00000143150 (from geneSymbol) uc338ras.1 uc338ras.1 
ENSMUST00000375034.1 ENSMUSG00000143151 ENSMUST00000375034.1 ENSMUSG00000143151 (from geneSymbol) AK140628 uc338rbc.1 uc338rbc.1 
ENSMUST00000375043.1 ENSMUSG00000143152 ENSMUST00000375043.1 ENSMUSG00000143152 (from geneSymbol) uc338rbl.1 uc338rbl.1 
ENSMUST00000375044.1 ENSMUSG00000143153 ENSMUST00000375044.1 ENSMUSG00000143153 (from geneSymbol) uc338rbm.1 uc338rbm.1 
ENSMUST00000375046.1 ENSMUSG00000143154 ENSMUST00000375046.1 ENSMUSG00000143154 (from geneSymbol) uc338rbo.1 uc338rbo.1 
ENSMUST00000375053.1 ENSMUSG00000143155 ENSMUST00000375053.1 ENSMUSG00000143155 (from geneSymbol) uc338rbv.1 uc338rbv.1 
ENSMUST00000375054.1 ENSMUSG00000143156 ENSMUST00000375054.1 ENSMUSG00000143156 (from geneSymbol) uc338rbw.1 uc338rbw.1 
ENSMUST00000375057.1 ENSMUSG00000143157 ENSMUST00000375057.1 ENSMUSG00000143157 (from geneSymbol) uc338rbz.1 uc338rbz.1 
ENSMUST00000375061.1 Gm20036 ENSMUST00000375061.1 predicted gene, 20036 (from RefSeq NR_152255.1) NR_152255 uc338rcd.1 uc338rcd.1 
ENSMUST00000375062.1 ENSMUSG00000143158 ENSMUST00000375062.1 ENSMUSG00000143158 (from geneSymbol) uc338rce.1 uc338rce.1 
ENSMUST00000375063.1 ENSMUSG00000143159 ENSMUST00000375063.1 ENSMUSG00000143159 (from geneSymbol) uc338rcf.1 uc338rcf.1 
ENSMUST00000375064.1 ENSMUSG00000143160 ENSMUST00000375064.1 ENSMUSG00000143160 (from geneSymbol) uc338rcg.1 uc338rcg.1 
ENSMUST00000375068.1 ENSMUSG00000143161 ENSMUST00000375068.1 ENSMUSG00000143161 (from geneSymbol) uc338rck.1 uc338rck.1 
ENSMUST00000375087.1 ENSMUSG00000143162 ENSMUST00000375087.1 ENSMUSG00000143162 (from geneSymbol) uc338rdd.1 uc338rdd.1 
ENSMUST00000375088.1 ENSMUSG00000143163 ENSMUST00000375088.1 ENSMUSG00000143163 (from geneSymbol) uc338rde.1 uc338rde.1 
ENSMUST00000375089.1 ENSMUSG00000143164 ENSMUST00000375089.1 ENSMUSG00000143164 (from geneSymbol) uc338rdf.1 uc338rdf.1 
ENSMUST00000375090.1 ENSMUSG00000143165 ENSMUST00000375090.1 ENSMUSG00000143165 (from geneSymbol) uc338rdg.1 uc338rdg.1 
ENSMUST00000375091.1 ENSMUSG00000143166 ENSMUST00000375091.1 ENSMUSG00000143166 (from geneSymbol) uc338rdh.1 uc338rdh.1 
ENSMUST00000375092.1 ENSMUSG00000143167 ENSMUST00000375092.1 ENSMUSG00000143167 (from geneSymbol) uc338rdi.1 uc338rdi.1 
ENSMUST00000375094.1 ENSMUSG00000143169 ENSMUST00000375094.1 ENSMUSG00000143169 (from geneSymbol) uc338rdj.1 uc338rdj.1 
ENSMUST00000375095.1 ENSMUSG00000143170 ENSMUST00000375095.1 ENSMUSG00000143170 (from geneSymbol) uc338rdk.1 uc338rdk.1 
ENSMUST00000375096.1 ENSMUSG00000143171 ENSMUST00000375096.1 ENSMUSG00000143171 (from geneSymbol) uc338rdl.1 uc338rdl.1 
ENSMUST00000375099.1 Gm34419 ENSMUST00000375099.1 Gm34419 (from geneSymbol) uc338rdo.1 uc338rdo.1 
ENSMUST00000375113.1 Gm38287 ENSMUST00000375113.1 Gm38287 (from geneSymbol) uc338rec.1 uc338rec.1 
ENSMUST00000375115.1 ENSMUSG00000143172 ENSMUST00000375115.1 ENSMUSG00000143172 (from geneSymbol) uc338ree.1 uc338ree.1 
ENSMUST00000375117.1 ENSMUSG00000143173 ENSMUST00000375117.1 ENSMUSG00000143173 (from geneSymbol) uc338reg.1 uc338reg.1 
ENSMUST00000375154.1 ENSMUSG00000143174 ENSMUST00000375154.1 ENSMUSG00000143174 (from geneSymbol) uc338rfr.1 uc338rfr.1 
ENSMUST00000375159.1 ENSMUSG00000143175 ENSMUST00000375159.1 ENSMUSG00000143175 (from geneSymbol) uc338rfw.1 uc338rfw.1 
ENSMUST00000375160.1 ENSMUSG00000143176 ENSMUST00000375160.1 ENSMUSG00000143176 (from geneSymbol) uc338rfx.1 uc338rfx.1 
ENSMUST00000375164.1 ENSMUSG00000143177 ENSMUST00000375164.1 ENSMUSG00000143177 (from geneSymbol) uc338rgb.1 uc338rgb.1 
ENSMUST00000375171.1 ENSMUSG00000143178 ENSMUST00000375171.1 ENSMUSG00000143178 (from geneSymbol) uc338rgi.1 uc338rgi.1 
ENSMUST00000375172.1 ENSMUSG00000143179 ENSMUST00000375172.1 ENSMUSG00000143179 (from geneSymbol) uc338rgj.1 uc338rgj.1 
ENSMUST00000375173.1 ENSMUSG00000143180 ENSMUST00000375173.1 ENSMUSG00000143180 (from geneSymbol) uc338rgk.1 uc338rgk.1 
ENSMUST00000375174.1 Gm43464 ENSMUST00000375174.1 Gm43464 (from geneSymbol) uc338rgl.1 uc338rgl.1 
ENSMUST00000375175.1 ENSMUSG00000143181 ENSMUST00000375175.1 ENSMUSG00000143181 (from geneSymbol) uc338rgm.1 uc338rgm.1 
ENSMUST00000375177.1 ENSMUSG00000143182 ENSMUST00000375177.1 ENSMUSG00000143182 (from geneSymbol) uc338rgo.1 uc338rgo.1 
ENSMUST00000375179.1 Gm20879 ENSMUST00000375179.1 predicted gene, 20879 (from RefSeq NR_164189.1) NR_164189 uc338rgq.1 uc338rgq.1 
ENSMUST00000375180.1 ENSMUSG00000143184 ENSMUST00000375180.1 ENSMUSG00000143184 (from geneSymbol) uc338rgr.1 uc338rgr.1 
ENSMUST00000375181.1 ENSMUSG00000143185 ENSMUST00000375181.1 ENSMUSG00000143185 (from geneSymbol) AK011444 uc338rgs.1 uc338rgs.1 
ENSMUST00000375188.1 ENSMUSG00000143186 ENSMUST00000375188.1 ENSMUSG00000143186 (from geneSymbol) uc338rgz.1 uc338rgz.1 
ENSMUST00000375189.1 ENSMUSG00000143187 ENSMUST00000375189.1 ENSMUSG00000143187 (from geneSymbol) uc338rha.1 uc338rha.1 
ENSMUST00000375190.1 ENSMUSG00000143188 ENSMUST00000375190.1 ENSMUSG00000143188 (from geneSymbol) uc338rhb.1 uc338rhb.1 
ENSMUST00000375194.1 ENSMUSG00000143189 ENSMUST00000375194.1 ENSMUSG00000143189 (from geneSymbol) uc338rhf.1 uc338rhf.1 
ENSMUST00000375198.1 ENSMUSG00000143190 ENSMUST00000375198.1 ENSMUSG00000143190 (from geneSymbol) uc338rhj.1 uc338rhj.1 
ENSMUST00000375199.1 ENSMUSG00000143191 ENSMUST00000375199.1 ENSMUSG00000143191 (from geneSymbol) uc338rhk.1 uc338rhk.1 
ENSMUST00000375200.1 Gm11842 ENSMUST00000375200.1 Gm11842 (from geneSymbol) uc338rhl.1 uc338rhl.1 
ENSMUST00000375208.1 Gm4598 ENSMUST00000375208.1 Gm4598 (from geneSymbol) AK087307 uc338rht.1 uc338rht.1 
ENSMUST00000375210.1 ENSMUSG00000143192 ENSMUST00000375210.1 ENSMUSG00000143192 (from geneSymbol) uc338rhv.1 uc338rhv.1 
ENSMUST00000375212.1 ENSMUSG00000143193 ENSMUST00000375212.1 ENSMUSG00000143193 (from geneSymbol) uc338rhx.1 uc338rhx.1 
ENSMUST00000375213.1 ENSMUSG00000143194 ENSMUST00000375213.1 ENSMUSG00000143194 (from geneSymbol) uc338rhy.1 uc338rhy.1 
ENSMUST00000375216.1 ENSMUSG00000143196 ENSMUST00000375216.1 ENSMUSG00000143196 (from geneSymbol) uc338ria.1 uc338ria.1 
ENSMUST00000375218.1 ENSMUSG00000143197 ENSMUST00000375218.1 ENSMUSG00000143197 (from geneSymbol) uc338ric.1 uc338ric.1 
ENSMUST00000375219.1 ENSMUSG00000143198 ENSMUST00000375219.1 ENSMUSG00000143198 (from geneSymbol) uc338rid.1 uc338rid.1 
ENSMUST00000375221.1 ENSMUSG00000143199 ENSMUST00000375221.1 ENSMUSG00000143199 (from geneSymbol) uc338rif.1 uc338rif.1 
ENSMUST00000375236.1 ENSMUSG00000143200 ENSMUST00000375236.1 ENSMUSG00000143200 (from geneSymbol) uc338riu.1 uc338riu.1 
ENSMUST00000375237.1 Gm56593 ENSMUST00000375237.1 Gm56593 (from geneSymbol) uc338riv.1 uc338riv.1 
ENSMUST00000375239.1 ENSMUSG00000143201 ENSMUST00000375239.1 ENSMUSG00000143201 (from geneSymbol) uc338rix.1 uc338rix.1 
ENSMUST00000375241.1 ENSMUSG00000143202 ENSMUST00000375241.1 ENSMUSG00000143202 (from geneSymbol) uc338riz.1 uc338riz.1 
ENSMUST00000375244.1 ENSMUSG00000143203 ENSMUST00000375244.1 ENSMUSG00000143203 (from geneSymbol) uc338rjc.1 uc338rjc.1 
ENSMUST00000375248.1 ENSMUSG00000143204 ENSMUST00000375248.1 ENSMUSG00000143204 (from geneSymbol) uc338rjg.1 uc338rjg.1 
ENSMUST00000375250.1 ENSMUSG00000143205 ENSMUST00000375250.1 ENSMUSG00000143205 (from geneSymbol) uc338rji.1 uc338rji.1 
ENSMUST00000375254.1 ENSMUSG00000143206 ENSMUST00000375254.1 ENSMUSG00000143206 (from geneSymbol) uc338rjm.1 uc338rjm.1 
ENSMUST00000375259.1 ENSMUSG00000143207 ENSMUST00000375259.1 ENSMUSG00000143207 (from geneSymbol) uc338rjr.1 uc338rjr.1 
ENSMUST00000375265.1 ENSMUSG00000143208 ENSMUST00000375265.1 ENSMUSG00000143208 (from geneSymbol) uc338rjx.1 uc338rjx.1 
ENSMUST00000375269.1 ENSMUSG00000143209 ENSMUST00000375269.1 ENSMUSG00000143209 (from geneSymbol) uc338rkb.1 uc338rkb.1 
ENSMUST00000375271.1 ENSMUSG00000143210 ENSMUST00000375271.1 ENSMUSG00000143210 (from geneSymbol) uc338rkd.1 uc338rkd.1 
ENSMUST00000375275.1 ENSMUSG00000143211 ENSMUST00000375275.1 ENSMUSG00000143211 (from geneSymbol) uc338rkh.1 uc338rkh.1 
ENSMUST00000375278.1 ENSMUSG00000143212 ENSMUST00000375278.1 ENSMUSG00000143212 (from geneSymbol) uc338rkk.1 uc338rkk.1 
ENSMUST00000375281.1 ENSMUSG00000143213 ENSMUST00000375281.1 ENSMUSG00000143213 (from geneSymbol) uc338rkn.1 uc338rkn.1 
ENSMUST00000375282.1 Oxct1as ENSMUST00000375282.1 Oxct1as (from geneSymbol) BC037032 uc338rko.1 uc338rko.1 
ENSMUST00000375291.1 ENSMUSG00000143214 ENSMUST00000375291.1 ENSMUSG00000143214 (from geneSymbol) uc338rkx.1 uc338rkx.1 
ENSMUST00000375292.1 Gm28497 ENSMUST00000375292.1 Gm28497 (from geneSymbol) uc338rky.1 uc338rky.1 
ENSMUST00000375296.1 Gm45625 ENSMUST00000375296.1 Gm45625 (from geneSymbol) uc338rlc.1 uc338rlc.1 
ENSMUST00000375298.1 ENSMUSG00000143215 ENSMUST00000375298.1 ENSMUSG00000143215 (from geneSymbol) uc338rle.1 uc338rle.1 
ENSMUST00000375302.1 ENSMUSG00000143216 ENSMUST00000375302.1 ENSMUSG00000143216 (from geneSymbol) uc338rli.1 uc338rli.1 
ENSMUST00000375303.1 ENSMUSG00000143217 ENSMUST00000375303.1 ENSMUSG00000143217 (from geneSymbol) uc338rlj.1 uc338rlj.1 
ENSMUST00000375305.1 ENSMUSG00000143218 ENSMUST00000375305.1 ENSMUSG00000143218 (from geneSymbol) uc338rll.1 uc338rll.1 
ENSMUST00000375320.1 ENSMUSG00000143219 ENSMUST00000375320.1 ENSMUSG00000143219 (from geneSymbol) uc338rma.1 uc338rma.1 
ENSMUST00000375322.1 Gm56932 ENSMUST00000375322.1 Gm56932 (from geneSymbol) uc338rmc.1 uc338rmc.1 
ENSMUST00000375332.1 ENSMUSG00000143220 ENSMUST00000375332.1 ENSMUSG00000143220 (from geneSymbol) uc338rmm.1 uc338rmm.1 
ENSMUST00000375333.1 ENSMUSG00000143221 ENSMUST00000375333.1 ENSMUSG00000143221 (from geneSymbol) uc338rmn.1 uc338rmn.1 
ENSMUST00000375335.1 ENSMUSG00000143222 ENSMUST00000375335.1 ENSMUSG00000143222 (from geneSymbol) uc338rmp.1 uc338rmp.1 
ENSMUST00000375337.1 ENSMUSG00000143223 ENSMUST00000375337.1 ENSMUSG00000143223 (from geneSymbol) uc338rmr.1 uc338rmr.1 
ENSMUST00000375338.1 ENSMUSG00000143224 ENSMUST00000375338.1 ENSMUSG00000143224 (from geneSymbol) AK084794 uc338rms.1 uc338rms.1 
ENSMUST00000375342.1 ENSMUSG00000143225 ENSMUST00000375342.1 ENSMUSG00000143225 (from geneSymbol) uc338rmw.1 uc338rmw.1 
ENSMUST00000375344.1 ENSMUSG00000143226 ENSMUST00000375344.1 ENSMUSG00000143226 (from geneSymbol) uc338rmy.1 uc338rmy.1 
ENSMUST00000375348.1 ENSMUSG00000143227 ENSMUST00000375348.1 ENSMUSG00000143227 (from geneSymbol) uc338rnc.1 uc338rnc.1 
ENSMUST00000375349.1 ENSMUSG00000143228 ENSMUST00000375349.1 ENSMUSG00000143228 (from geneSymbol) uc338rnd.1 uc338rnd.1 
ENSMUST00000375350.1 ENSMUSG00000143229 ENSMUST00000375350.1 ENSMUSG00000143229 (from geneSymbol) uc338rne.1 uc338rne.1 
ENSMUST00000375351.1 ENSMUSG00000143230 ENSMUST00000375351.1 ENSMUSG00000143230 (from geneSymbol) uc338rnf.1 uc338rnf.1 
ENSMUST00000375353.1 ENSMUSG00000143231 ENSMUST00000375353.1 ENSMUSG00000143231 (from geneSymbol) uc338rnh.1 uc338rnh.1 
ENSMUST00000375354.1 ENSMUSG00000143232 ENSMUST00000375354.1 ENSMUSG00000143232 (from geneSymbol) uc338rni.1 uc338rni.1 
ENSMUST00000375355.1 Gm15669 ENSMUST00000375355.1 Gm15669 (from geneSymbol) uc338rnj.1 uc338rnj.1 
ENSMUST00000375361.1 ENSMUSG00000143233 ENSMUST00000375361.1 ENSMUSG00000143233 (from geneSymbol) uc338rnp.1 uc338rnp.1 
ENSMUST00000375362.1 ENSMUSG00000143234 ENSMUST00000375362.1 ENSMUSG00000143234 (from geneSymbol) uc338rnq.1 uc338rnq.1 
ENSMUST00000375363.1 ENSMUSG00000143235 ENSMUST00000375363.1 ENSMUSG00000143235 (from geneSymbol) uc338rnr.1 uc338rnr.1 
ENSMUST00000375364.1 ENSMUSG00000143236 ENSMUST00000375364.1 ENSMUSG00000143236 (from geneSymbol) uc338rns.1 uc338rns.1 
ENSMUST00000375367.1 ENSMUSG00000143237 ENSMUST00000375367.1 ENSMUSG00000143237 (from geneSymbol) uc338rnv.1 uc338rnv.1 
ENSMUST00000375378.1 ENSMUSG00000143238 ENSMUST00000375378.1 ENSMUSG00000143238 (from geneSymbol) uc338rog.1 uc338rog.1 
ENSMUST00000375379.1 ENSMUSG00000143239 ENSMUST00000375379.1 ENSMUSG00000143239 (from geneSymbol) uc338roh.1 uc338roh.1 
ENSMUST00000375388.1 Gm49805 ENSMUST00000375388.1 Gm49805 (from geneSymbol) uc338roq.1 uc338roq.1 
ENSMUST00000375390.1 ENSMUSG00000143240 ENSMUST00000375390.1 ENSMUSG00000143240 (from geneSymbol) uc338ros.1 uc338ros.1 
ENSMUST00000375398.1 ENSMUSG00000143241 ENSMUST00000375398.1 ENSMUSG00000143241 (from geneSymbol) uc338rpa.1 uc338rpa.1 
ENSMUST00000375399.1 Gm31717 ENSMUST00000375399.1 Gm31717 (from geneSymbol) uc338rpb.1 uc338rpb.1 
ENSMUST00000375416.1 ENSMUSG00000143242 ENSMUST00000375416.1 ENSMUSG00000143242 (from geneSymbol) uc338rps.1 uc338rps.1 
ENSMUST00000375429.1 ENSMUSG00000143243 ENSMUST00000375429.1 ENSMUSG00000143243 (from geneSymbol) uc338rqe.1 uc338rqe.1 
ENSMUST00000375434.1 AW822252 ENSMUST00000375434.1 AW822252 (from geneSymbol) AK082553 uc338rqj.1 uc338rqj.1 
ENSMUST00000375583.1 ENSMUSG00000143244 ENSMUST00000375583.1 ENSMUSG00000143244 (from geneSymbol) uc338rwc.1 uc338rwc.1 
ENSMUST00000375584.1 ENSMUSG00000143245 ENSMUST00000375584.1 ENSMUSG00000143245 (from geneSymbol) uc338rwd.1 uc338rwd.1 
ENSMUST00000375585.1 ENSMUSG00000143246 ENSMUST00000375585.1 ENSMUSG00000143246 (from geneSymbol) uc338rwe.1 uc338rwe.1 
ENSMUST00000375587.1 ENSMUSG00000143247 ENSMUST00000375587.1 ENSMUSG00000143247 (from geneSymbol) uc338rwg.1 uc338rwg.1 
ENSMUST00000375588.1 ENSMUSG00000143248 ENSMUST00000375588.1 ENSMUSG00000143248 (from geneSymbol) uc338rwh.1 uc338rwh.1 
ENSMUST00000375589.1 ENSMUSG00000143249 ENSMUST00000375589.1 ENSMUSG00000143249 (from geneSymbol) uc338rwi.1 uc338rwi.1 
ENSMUST00000375590.1 ENSMUSG00000143250 ENSMUST00000375590.1 ENSMUSG00000143250 (from geneSymbol) uc338rwj.1 uc338rwj.1 
ENSMUST00000375591.1 ENSMUSG00000143251 ENSMUST00000375591.1 ENSMUSG00000143251 (from geneSymbol) uc338rwk.1 uc338rwk.1 
ENSMUST00000375596.1 Gm56529 ENSMUST00000375596.1 Gm56529 (from geneSymbol) AK080484 uc338rwp.1 uc338rwp.1 
ENSMUST00000375613.1 Gm15632 ENSMUST00000375613.1 Gm15632 (from geneSymbol) AK028088 uc338rxc.1 uc338rxc.1 
ENSMUST00000375642.1 ENSMUSG00000143252 ENSMUST00000375642.1 ENSMUSG00000143252 (from geneSymbol) uc338ryb.1 uc338ryb.1 
ENSMUST00000375645.1 ENSMUSG00000143254 ENSMUST00000375645.1 ENSMUSG00000143254 (from geneSymbol) uc338ryc.1 uc338ryc.1 
ENSMUST00000375646.1 ENSMUSG00000143255 ENSMUST00000375646.1 ENSMUSG00000143255 (from geneSymbol) uc338ryd.1 uc338ryd.1 
ENSMUST00000375648.1 ENSMUSG00000143256 ENSMUST00000375648.1 ENSMUSG00000143256 (from geneSymbol) uc338ryf.1 uc338ryf.1 
ENSMUST00000375657.1 Gm47467 ENSMUST00000375657.1 Gm47467 (from geneSymbol) uc338ryo.1 uc338ryo.1 
ENSMUST00000375678.1 Gm16731 ENSMUST00000375678.1 Gm16731 (from geneSymbol) AK164782 uc338rzj.1 uc338rzj.1 
ENSMUST00000375682.1 ENSMUSG00000143257 ENSMUST00000375682.1 ENSMUSG00000143257 (from geneSymbol) uc338rzn.1 uc338rzn.1 
ENSMUST00000375686.1 ENSMUSG00000143258 ENSMUST00000375686.1 ENSMUSG00000143258 (from geneSymbol) uc338rzr.1 uc338rzr.1 
ENSMUST00000375687.1 ENSMUSG00000143259 ENSMUST00000375687.1 ENSMUSG00000143259 (from geneSymbol) uc338rzs.1 uc338rzs.1 
ENSMUST00000375688.1 ENSMUSG00000143260 ENSMUST00000375688.1 ENSMUSG00000143260 (from geneSymbol) uc338rzt.1 uc338rzt.1 
ENSMUST00000375690.1 ENSMUSG00000143261 ENSMUST00000375690.1 ENSMUSG00000143261 (from geneSymbol) uc338rzv.1 uc338rzv.1 
ENSMUST00000375699.1 ENSMUSG00000143262 ENSMUST00000375699.1 ENSMUSG00000143262 (from geneSymbol) uc338sae.1 uc338sae.1 
ENSMUST00000375700.1 Gm31064 ENSMUST00000375700.1 Gm31064 (from geneSymbol) uc338saf.1 uc338saf.1 
ENSMUST00000375711.1 ENSMUSG00000143264 ENSMUST00000375711.1 ENSMUSG00000143264 (from geneSymbol) uc338saq.1 uc338saq.1 
ENSMUST00000375712.1 ENSMUSG00000143265 ENSMUST00000375712.1 ENSMUSG00000143265 (from geneSymbol) uc338sar.1 uc338sar.1 
ENSMUST00000375726.1 Gm53207 ENSMUST00000375726.1 Gm53207 (from geneSymbol) uc338sbf.1 uc338sbf.1 
ENSMUST00000375730.1 Gm35801 ENSMUST00000375730.1 Gm35801 (from geneSymbol) uc338sbj.1 uc338sbj.1 
ENSMUST00000375735.1 ENSMUSG00000143266 ENSMUST00000375735.1 ENSMUSG00000143266 (from geneSymbol) uc338sbo.1 uc338sbo.1 
ENSMUST00000375736.1 ENSMUSG00000143267 ENSMUST00000375736.1 ENSMUSG00000143267 (from geneSymbol) uc338sbp.1 uc338sbp.1 
ENSMUST00000375737.1 ENSMUSG00000143268 ENSMUST00000375737.1 ENSMUSG00000143268 (from geneSymbol) uc338sbq.1 uc338sbq.1 
ENSMUST00000375738.1 ENSMUSG00000143269 ENSMUST00000375738.1 ENSMUSG00000143269 (from geneSymbol) uc338sbr.1 uc338sbr.1 
ENSMUST00000375743.1 ENSMUSG00000143270 ENSMUST00000375743.1 ENSMUSG00000143270 (from geneSymbol) uc338sbw.1 uc338sbw.1 
ENSMUST00000375744.1 ENSMUSG00000143271 ENSMUST00000375744.1 ENSMUSG00000143271 (from geneSymbol) uc338sbx.1 uc338sbx.1 
ENSMUST00000375746.1 ENSMUSG00000143272 ENSMUST00000375746.1 ENSMUSG00000143272 (from geneSymbol) uc338sbz.1 uc338sbz.1 
ENSMUST00000375747.1 ENSMUSG00000143273 ENSMUST00000375747.1 ENSMUSG00000143273 (from geneSymbol) uc338sca.1 uc338sca.1 
ENSMUST00000375749.1 ENSMUSG00000143274 ENSMUST00000375749.1 ENSMUSG00000143274 (from geneSymbol) uc338scc.1 uc338scc.1 
ENSMUST00000375752.1 ENSMUSG00000143276 ENSMUST00000375752.1 ENSMUSG00000143276 (from geneSymbol) uc338sce.1 uc338sce.1 
ENSMUST00000375780.1 ENSMUSG00000143277 ENSMUST00000375780.1 ENSMUSG00000143277 (from geneSymbol) uc338sdg.1 uc338sdg.1 
ENSMUST00000375784.1 ENSMUSG00000143278 ENSMUST00000375784.1 ENSMUSG00000143278 (from geneSymbol) uc338sdk.1 uc338sdk.1 
ENSMUST00000375787.1 ENSMUSG00000143280 ENSMUST00000375787.1 ENSMUSG00000143280 (from geneSymbol) BC145074 uc338sdl.1 uc338sdl.1 
ENSMUST00000375789.1 ENSMUSG00000143281 ENSMUST00000375789.1 ENSMUSG00000143281 (from geneSymbol) uc338sdn.1 uc338sdn.1 
ENSMUST00000375798.1 Gm35657 ENSMUST00000375798.1 Gm35657 (from geneSymbol) uc338sdw.1 uc338sdw.1 
ENSMUST00000375820.1 ENSMUSG00000143282 ENSMUST00000375820.1 ENSMUSG00000143282 (from geneSymbol) uc338ses.1 uc338ses.1 
ENSMUST00000375823.1 ENSMUSG00000143283 ENSMUST00000375823.1 ENSMUSG00000143283 (from geneSymbol) uc338sev.1 uc338sev.1 
ENSMUST00000375824.1 ENSMUSG00000143284 ENSMUST00000375824.1 ENSMUSG00000143284 (from geneSymbol) uc338sew.1 uc338sew.1 
ENSMUST00000375825.1 ENSMUSG00000143285 ENSMUST00000375825.1 ENSMUSG00000143285 (from geneSymbol) uc338sex.1 uc338sex.1 
ENSMUST00000375826.1 ENSMUSG00000143286 ENSMUST00000375826.1 ENSMUSG00000143286 (from geneSymbol) uc338sey.1 uc338sey.1 
ENSMUST00000375827.1 ENSMUSG00000143287 ENSMUST00000375827.1 ENSMUSG00000143287 (from geneSymbol) uc338sez.1 uc338sez.1 
ENSMUST00000375828.1 ENSMUSG00000143288 ENSMUST00000375828.1 ENSMUSG00000143288 (from geneSymbol) uc338sfa.1 uc338sfa.1 
ENSMUST00000375838.1 ENSMUSG00000143289 ENSMUST00000375838.1 ENSMUSG00000143289 (from geneSymbol) AK007248 uc338sfk.1 uc338sfk.1 
ENSMUST00000375839.1 ENSMUSG00000143290 ENSMUST00000375839.1 ENSMUSG00000143290 (from geneSymbol) uc338sfl.1 uc338sfl.1 
ENSMUST00000375840.1 Gm37073 ENSMUST00000375840.1 Gm37073 (from geneSymbol) uc338sfm.1 uc338sfm.1 
ENSMUST00000375845.1 ENSMUSG00000143292 ENSMUST00000375845.1 ENSMUSG00000143292 (from geneSymbol) uc338sfr.1 uc338sfr.1 
ENSMUST00000375849.1 ENSMUSG00000143293 ENSMUST00000375849.1 ENSMUSG00000143293 (from geneSymbol) uc338sfv.1 uc338sfv.1 
ENSMUST00000375854.1 ENSMUSG00000143294 ENSMUST00000375854.1 ENSMUSG00000143294 (from geneSymbol) uc338sga.1 uc338sga.1 
ENSMUST00000375855.1 ENSMUSG00000143295 ENSMUST00000375855.1 ENSMUSG00000143295 (from geneSymbol) uc338sgb.1 uc338sgb.1 
ENSMUST00000375856.1 ENSMUSG00000143296 ENSMUST00000375856.1 ENSMUSG00000143296 (from geneSymbol) uc338sgc.1 uc338sgc.1 
ENSMUST00000375857.1 ENSMUSG00000143297 ENSMUST00000375857.1 ENSMUSG00000143297 (from geneSymbol) uc338sgd.1 uc338sgd.1 
ENSMUST00000375858.1 Gm13180 ENSMUST00000375858.1 Gm13180 (from geneSymbol) AK139653 uc338sge.1 uc338sge.1 
ENSMUST00000375864.1 ENSMUSG00000143298 ENSMUST00000375864.1 ENSMUSG00000143298 (from geneSymbol) uc338sgk.1 uc338sgk.1 
ENSMUST00000375866.1 ENSMUSG00000143299 ENSMUST00000375866.1 ENSMUSG00000143299 (from geneSymbol) uc338sgm.1 uc338sgm.1 
ENSMUST00000375875.1 ENSMUSG00000143300 ENSMUST00000375875.1 ENSMUSG00000143300 (from geneSymbol) uc338sgv.1 uc338sgv.1 
ENSMUST00000375880.1 ENSMUSG00000143301 ENSMUST00000375880.1 ENSMUSG00000143301 (from geneSymbol) uc338sha.1 uc338sha.1 
ENSMUST00000375892.1 ENSMUSG00000143302 ENSMUST00000375892.1 ENSMUSG00000143302 (from geneSymbol) uc338shm.1 uc338shm.1 
ENSMUST00000375893.1 ENSMUSG00000143303 ENSMUST00000375893.1 ENSMUSG00000143303 (from geneSymbol) uc338shn.1 uc338shn.1 
ENSMUST00000375894.1 ENSMUSG00000143304 ENSMUST00000375894.1 ENSMUSG00000143304 (from geneSymbol) LF304208 uc338sho.1 uc338sho.1 
ENSMUST00000375895.1 ENSMUSG00000143305 ENSMUST00000375895.1 ENSMUSG00000143305 (from geneSymbol) uc338shp.1 uc338shp.1 
ENSMUST00000375896.1 ENSMUSG00000143306 ENSMUST00000375896.1 ENSMUSG00000143306 (from geneSymbol) uc338shq.1 uc338shq.1 
ENSMUST00000375897.1 ENSMUSG00000143307 ENSMUST00000375897.1 ENSMUSG00000143307 (from geneSymbol) uc338shr.1 uc338shr.1 
ENSMUST00000375899.1 ENSMUSG00000143308 ENSMUST00000375899.1 ENSMUSG00000143308 (from geneSymbol) uc338sht.1 uc338sht.1 
ENSMUST00000375900.1 ENSMUSG00000143309 ENSMUST00000375900.1 ENSMUSG00000143309 (from geneSymbol) uc338shu.1 uc338shu.1 
ENSMUST00000375901.1 Gm10069 ENSMUST00000375901.1 Gm10069 (from geneSymbol) AK046088 uc338shv.1 uc338shv.1 
ENSMUST00000375946.1 ENSMUSG00000143310 ENSMUST00000375946.1 ENSMUSG00000143310 (from geneSymbol) uc338sjo.1 uc338sjo.1 
ENSMUST00000375947.1 ENSMUSG00000143311 ENSMUST00000375947.1 ENSMUSG00000143311 (from geneSymbol) uc338sjp.1 uc338sjp.1 
ENSMUST00000375950.1 ENSMUSG00000143312 ENSMUST00000375950.1 ENSMUSG00000143312 (from geneSymbol) uc338sjs.1 uc338sjs.1 
ENSMUST00000375951.1 ENSMUSG00000143313 ENSMUST00000375951.1 ENSMUSG00000143313 (from geneSymbol) uc338sjt.1 uc338sjt.1 
ENSMUST00000375953.1 ENSMUSG00000143314 ENSMUST00000375953.1 ENSMUSG00000143314 (from geneSymbol) uc338sjv.1 uc338sjv.1 
ENSMUST00000375959.1 Gm31186 ENSMUST00000375959.1 Gm31186 (from geneSymbol) uc338skb.1 uc338skb.1 
ENSMUST00000375961.1 ENSMUSG00000143317 ENSMUST00000375961.1 ENSMUSG00000143317 (from geneSymbol) uc338skc.1 uc338skc.1 
ENSMUST00000375962.1 ENSMUSG00000143318 ENSMUST00000375962.1 ENSMUSG00000143318 (from geneSymbol) uc338skd.1 uc338skd.1 
ENSMUST00000375964.1 Gm33045 ENSMUST00000375964.1 Gm33045 (from geneSymbol) AK140017 uc338skf.1 uc338skf.1 
ENSMUST00000376015.1 ENSMUSG00000143319 ENSMUST00000376015.1 ENSMUSG00000143319 (from geneSymbol) uc338sme.1 uc338sme.1 
ENSMUST00000376017.1 ENSMUSG00000143320 ENSMUST00000376017.1 ENSMUSG00000143320 (from geneSymbol) uc338smg.1 uc338smg.1 
ENSMUST00000376018.1 ENSMUSG00000143321 ENSMUST00000376018.1 ENSMUSG00000143321 (from geneSymbol) uc338smh.1 uc338smh.1 
ENSMUST00000376019.1 ENSMUSG00000143322 ENSMUST00000376019.1 ENSMUSG00000143322 (from geneSymbol) uc338smi.1 uc338smi.1 
ENSMUST00000376021.1 6430710C18Rik ENSMUST00000376021.1 6430710C18Rik (from geneSymbol) AK019889 uc338smk.1 uc338smk.1 
ENSMUST00000376161.1 Gm14424 ENSMUST00000376161.1 Gm14424 (from geneSymbol) AK144266 uc338srt.1 uc338srt.1 
ENSMUST00000376195.1 ENSMUSG00000143324 ENSMUST00000376195.1 ENSMUSG00000143324 (from geneSymbol) uc338sta.1 uc338sta.1 
ENSMUST00000376197.1 ENSMUSG00000143325 ENSMUST00000376197.1 ENSMUSG00000143325 (from geneSymbol) uc338stc.1 uc338stc.1 
ENSMUST00000376199.1 ENSMUSG00000143326 ENSMUST00000376199.1 ENSMUSG00000143326 (from geneSymbol) uc338ste.1 uc338ste.1 
ENSMUST00000376200.1 ENSMUSG00000143327 ENSMUST00000376200.1 ENSMUSG00000143327 (from geneSymbol) AK143349 uc338stf.1 uc338stf.1 
ENSMUST00000376202.1 Gm57365 ENSMUST00000376202.1 Gm57365 (from geneSymbol) uc338sth.1 uc338sth.1 
ENSMUST00000376205.1 1810053B23Rik ENSMUST00000376205.1 1810053B23Rik (from geneSymbol) AK160158 uc338stk.1 uc338stk.1 
ENSMUST00000376250.1 ENSMUSG00000143328 ENSMUST00000376250.1 ENSMUSG00000143328 (from geneSymbol) uc338svd.1 uc338svd.1 
ENSMUST00000376251.1 ENSMUSG00000143329 ENSMUST00000376251.1 ENSMUSG00000143329 (from geneSymbol) uc338sve.1 uc338sve.1 
ENSMUST00000376252.1 ENSMUSG00000143330 ENSMUST00000376252.1 ENSMUSG00000143330 (from geneSymbol) uc338svf.1 uc338svf.1 
ENSMUST00000376253.1 ENSMUSG00000143331 ENSMUST00000376253.1 ENSMUSG00000143331 (from geneSymbol) uc338svg.1 uc338svg.1 
ENSMUST00000376254.1 ENSMUSG00000143332 ENSMUST00000376254.1 ENSMUSG00000143332 (from geneSymbol) uc338svh.1 uc338svh.1 
ENSMUST00000376255.1 Gm57418 ENSMUST00000376255.1 Gm57418 (from geneSymbol) uc338svi.1 uc338svi.1 
ENSMUST00000376256.1 ENSMUSG00000143333 ENSMUST00000376256.1 ENSMUSG00000143333 (from geneSymbol) uc338svj.1 uc338svj.1 
ENSMUST00000376257.1 ENSMUSG00000143334 ENSMUST00000376257.1 ENSMUSG00000143334 (from geneSymbol) uc338svk.1 uc338svk.1 
ENSMUST00000376258.1 4930488N15Rik ENSMUST00000376258.1 4930488N15Rik (from geneSymbol) AK015648 uc338svl.1 uc338svl.1 
ENSMUST00000376268.1 ENSMUSG00000143335 ENSMUST00000376268.1 ENSMUSG00000143335 (from geneSymbol) uc338svv.1 uc338svv.1 
ENSMUST00000376272.1 1700029K24Rik ENSMUST00000376272.1 1700029K24Rik (from geneSymbol) uc338svz.1 uc338svz.1 
ENSMUST00000376275.1 ENSMUSG00000143336 ENSMUST00000376275.1 ENSMUSG00000143336 (from geneSymbol) X62581 uc338swc.1 uc338swc.1 
ENSMUST00000376282.1 ENSMUSG00000143337 ENSMUST00000376282.1 ENSMUSG00000143337 (from geneSymbol) uc338swj.1 uc338swj.1 
ENSMUST00000376294.1 ENSMUSG00000143338 ENSMUST00000376294.1 ENSMUSG00000143338 (from geneSymbol) uc338swv.1 uc338swv.1 
ENSMUST00000376298.1 ENSMUSG00000143339 ENSMUST00000376298.1 ENSMUSG00000143339 (from geneSymbol) uc338swz.1 uc338swz.1 
ENSMUST00000376301.1 ENSMUSG00000143341 ENSMUST00000376301.1 ENSMUSG00000143341 (from geneSymbol) uc338sxb.1 uc338sxb.1 
ENSMUST00000376302.1 ENSMUSG00000143342 ENSMUST00000376302.1 ENSMUSG00000143342 (from geneSymbol) uc338sxc.1 uc338sxc.1 
ENSMUST00000376304.1 ENSMUSG00000143343 ENSMUST00000376304.1 ENSMUSG00000143343 (from geneSymbol) uc338sxe.1 uc338sxe.1 
ENSMUST00000376305.1 ENSMUSG00000143344 ENSMUST00000376305.1 ENSMUSG00000143344 (from geneSymbol) uc338sxf.1 uc338sxf.1 
ENSMUST00000376310.1 ENSMUSG00000143345 ENSMUST00000376310.1 ENSMUSG00000143345 (from geneSymbol) uc338sxk.1 uc338sxk.1 
ENSMUST00000376312.1 ENSMUSG00000143346 ENSMUST00000376312.1 ENSMUSG00000143346 (from geneSymbol) uc338sxm.1 uc338sxm.1 
ENSMUST00000376314.1 ENSMUSG00000143347 ENSMUST00000376314.1 ENSMUSG00000143347 (from geneSymbol) uc338sxo.1 uc338sxo.1 
ENSMUST00000376315.1 ENSMUSG00000143348 ENSMUST00000376315.1 ENSMUSG00000143348 (from geneSymbol) uc338sxp.1 uc338sxp.1 
ENSMUST00000376316.1 ENSMUSG00000143349 ENSMUST00000376316.1 ENSMUSG00000143349 (from geneSymbol) uc338sxq.1 uc338sxq.1 
ENSMUST00000376317.1 ENSMUSG00000143350 ENSMUST00000376317.1 ENSMUSG00000143350 (from geneSymbol) uc338sxr.1 uc338sxr.1 
ENSMUST00000376320.1 ENSMUSG00000143351 ENSMUST00000376320.1 ENSMUSG00000143351 (from geneSymbol) uc338sxu.1 uc338sxu.1 
ENSMUST00000376321.1 ENSMUSG00000143352 ENSMUST00000376321.1 ENSMUSG00000143352 (from geneSymbol) uc338sxv.1 uc338sxv.1 
ENSMUST00000376322.1 ENSMUSG00000143353 ENSMUST00000376322.1 ENSMUSG00000143353 (from geneSymbol) uc338sxw.1 uc338sxw.1 
ENSMUST00000376328.1 4930401C15Rik ENSMUST00000376328.1 4930401C15Rik (from geneSymbol) AK015032 uc338syc.1 uc338syc.1 
ENSMUST00000376332.1 ENSMUSG00000143354 ENSMUST00000376332.1 ENSMUSG00000143354 (from geneSymbol) uc338syg.1 uc338syg.1 
ENSMUST00000376337.1 ENSMUSG00000143355 ENSMUST00000376337.1 ENSMUSG00000143355 (from geneSymbol) uc338syl.1 uc338syl.1 
ENSMUST00000376341.1 ENSMUSG00000143356 ENSMUST00000376341.1 ENSMUSG00000143356 (from geneSymbol) uc338syp.1 uc338syp.1 
ENSMUST00000376343.1 ENSMUSG00000143357 ENSMUST00000376343.1 ENSMUSG00000143357 (from geneSymbol) uc338syr.1 uc338syr.1 
ENSMUST00000376344.1 ENSMUSG00000143358 ENSMUST00000376344.1 ENSMUSG00000143358 (from geneSymbol) uc338sys.1 uc338sys.1 
ENSMUST00000376346.1 ENSMUSG00000143359 ENSMUST00000376346.1 ENSMUSG00000143359 (from geneSymbol) uc338syu.1 uc338syu.1 
ENSMUST00000376347.1 ENSMUSG00000143360 ENSMUST00000376347.1 ENSMUSG00000143360 (from geneSymbol) uc338syv.1 uc338syv.1 
ENSMUST00000376350.1 ENSMUSG00000143361 ENSMUST00000376350.1 ENSMUSG00000143361 (from geneSymbol) uc338syy.1 uc338syy.1 
ENSMUST00000376351.1 ENSMUSG00000143362 ENSMUST00000376351.1 ENSMUSG00000143362 (from geneSymbol) uc338syz.1 uc338syz.1 
ENSMUST00000376354.1 4930573I07Rik ENSMUST00000376354.1 4930573I07Rik (from geneSymbol) AK019810 uc338szc.1 uc338szc.1 
ENSMUST00000376363.1 ENSMUSG00000143363 ENSMUST00000376363.1 ENSMUSG00000143363 (from geneSymbol) uc338szl.1 uc338szl.1 
ENSMUST00000376368.1 ENSMUSG00000143364 ENSMUST00000376368.1 ENSMUSG00000143364 (from geneSymbol) uc338szq.1 uc338szq.1 
ENSMUST00000376369.1 ENSMUSG00000143365 ENSMUST00000376369.1 ENSMUSG00000143365 (from geneSymbol) uc338szr.1 uc338szr.1 
ENSMUST00000376370.1 ENSMUSG00000143366 ENSMUST00000376370.1 ENSMUSG00000143366 (from geneSymbol) uc338szs.1 uc338szs.1 
ENSMUST00000376373.1 ENSMUSG00000143367 ENSMUST00000376373.1 ENSMUSG00000143367 (from geneSymbol) uc338szv.1 uc338szv.1 
ENSMUST00000376374.1 ENSMUSG00000143368 ENSMUST00000376374.1 ENSMUSG00000143368 (from geneSymbol) uc338szw.1 uc338szw.1 
ENSMUST00000376385.1 Gm11482 ENSMUST00000376385.1 Gm11482 (from geneSymbol) AK077143 uc338tah.1 uc338tah.1 
ENSMUST00000376403.1 1810044K17Rik ENSMUST00000376403.1 1810044K17Rik (from geneSymbol) AK007778 uc338taz.1 uc338taz.1 
ENSMUST00000376408.1 ENSMUSG00000143369 ENSMUST00000376408.1 ENSMUSG00000143369 (from geneSymbol) uc338tbe.1 uc338tbe.1 
ENSMUST00000376409.1 ENSMUSG00000143370 ENSMUST00000376409.1 ENSMUSG00000143370 (from geneSymbol) uc338tbf.1 uc338tbf.1 
ENSMUST00000376410.1 ENSMUSG00000143371 ENSMUST00000376410.1 ENSMUSG00000143371 (from geneSymbol) BC100413 uc338tbg.1 uc338tbg.1 
ENSMUST00000376412.1 Gm15966 ENSMUST00000376412.1 Gm15966 (from geneSymbol) uc338tbi.1 uc338tbi.1 
ENSMUST00000376420.1 ENSMUSG00000143372 ENSMUST00000376420.1 ENSMUSG00000143372 (from geneSymbol) uc338tbq.1 uc338tbq.1 
ENSMUST00000376423.1 ENSMUSG00000143373 ENSMUST00000376423.1 ENSMUSG00000143373 (from geneSymbol) uc338tbt.1 uc338tbt.1 
ENSMUST00000376430.1 Gm33533 ENSMUST00000376430.1 Gm33533 (from geneSymbol) AK158561 uc338tca.1 uc338tca.1 
ENSMUST00000376433.1 ENSMUSG00000143374 ENSMUST00000376433.1 ENSMUSG00000143374 (from geneSymbol) uc338tcd.1 uc338tcd.1 
ENSMUST00000376436.1 4732471J01Rik ENSMUST00000376436.1 4732471J01Rik (from geneSymbol) AK161422 uc338tcg.1 uc338tcg.1 
ENSMUST00000376464.1 ENSMUSG00000143375 ENSMUST00000376464.1 ENSMUSG00000143375 (from geneSymbol) uc338tdi.1 uc338tdi.1 
ENSMUST00000376468.1 ENSMUSG00000143376 ENSMUST00000376468.1 ENSMUSG00000143376 (from geneSymbol) uc338tdm.1 uc338tdm.1 
ENSMUST00000376474.1 ENSMUSG00000143377 ENSMUST00000376474.1 ENSMUSG00000143377 (from geneSymbol) uc338tdq.1 uc338tdq.1 
ENSMUST00000376477.1 ENSMUSG00000143378 ENSMUST00000376477.1 ENSMUSG00000143378 (from geneSymbol) uc338tds.1 uc338tds.1 
ENSMUST00000376479.1 ENSMUSG00000143379 ENSMUST00000376479.1 ENSMUSG00000143379 (from geneSymbol) uc338tdu.1 uc338tdu.1 
ENSMUST00000376483.1 Gm38408 ENSMUST00000376483.1 Gm38408 (from geneSymbol) AK081031 uc338tdy.1 uc338tdy.1 
ENSMUST00000376494.1 4933424L21Rik ENSMUST00000376494.1 4933424L21Rik (from geneSymbol) AK016898 uc338tej.1 uc338tej.1 
ENSMUST00000376502.1 4930452N14Rik ENSMUST00000376502.1 4930452N14Rik (from geneSymbol) AK019628 uc338ter.1 uc338ter.1 
ENSMUST00000376513.1 ENSMUSG00000143380 ENSMUST00000376513.1 ENSMUSG00000143380 (from geneSymbol) uc338tfc.1 uc338tfc.1 
ENSMUST00000376514.1 ENSMUSG00000143381 ENSMUST00000376514.1 ENSMUSG00000143381 (from geneSymbol) uc338tfd.1 uc338tfd.1 
ENSMUST00000376516.1 ENSMUSG00000143382 ENSMUST00000376516.1 ENSMUSG00000143382 (from geneSymbol) uc338tff.1 uc338tff.1 
ENSMUST00000376518.1 ENSMUSG00000143383 ENSMUST00000376518.1 ENSMUSG00000143383 (from geneSymbol) uc338tfh.1 uc338tfh.1 
ENSMUST00000376522.1 ENSMUSG00000143384 ENSMUST00000376522.1 ENSMUSG00000143384 (from geneSymbol) uc338tfl.1 uc338tfl.1 
ENSMUST00000376523.1 ENSMUSG00000143385 ENSMUST00000376523.1 ENSMUSG00000143385 (from geneSymbol) uc338tfm.1 uc338tfm.1 
ENSMUST00000376533.1 ENSMUSG00000143386 ENSMUST00000376533.1 ENSMUSG00000143386 (from geneSymbol) uc338tfw.1 uc338tfw.1 
ENSMUST00000376537.1 ENSMUSG00000143387 ENSMUST00000376537.1 ENSMUSG00000143387 (from geneSymbol) uc338tga.1 uc338tga.1 
ENSMUST00000376538.1 ENSMUSG00000143388 ENSMUST00000376538.1 ENSMUSG00000143388 (from geneSymbol) uc338tgb.1 uc338tgb.1 
ENSMUST00000376539.1 ENSMUSG00000143389 ENSMUST00000376539.1 ENSMUSG00000143389 (from geneSymbol) uc338tgc.1 uc338tgc.1 
ENSMUST00000376540.1 ENSMUSG00000143390 ENSMUST00000376540.1 ENSMUSG00000143390 (from geneSymbol) uc338tgd.1 uc338tgd.1 
ENSMUST00000376543.1 ENSMUSG00000143392 ENSMUST00000376543.1 ENSMUSG00000143392 (from geneSymbol) uc338tgf.1 uc338tgf.1 
ENSMUST00000376544.1 ENSMUSG00000143393 ENSMUST00000376544.1 ENSMUSG00000143393 (from geneSymbol) uc338tgg.1 uc338tgg.1 
ENSMUST00000376546.1 ENSMUSG00000143394 ENSMUST00000376546.1 ENSMUSG00000143394 (from geneSymbol) uc338tgi.1 uc338tgi.1 
ENSMUST00000376547.1 ENSMUSG00000143395 ENSMUST00000376547.1 ENSMUSG00000143395 (from geneSymbol) uc338tgj.1 uc338tgj.1 
ENSMUST00000376548.1 ENSMUSG00000143396 ENSMUST00000376548.1 ENSMUSG00000143396 (from geneSymbol) uc338tgk.1 uc338tgk.1 
ENSMUST00000376552.1 ENSMUSG00000143398 ENSMUST00000376552.1 ENSMUSG00000143398 (from geneSymbol) uc338tgm.1 uc338tgm.1 
ENSMUST00000376556.1 ENSMUSG00000143399 ENSMUST00000376556.1 ENSMUSG00000143399 (from geneSymbol) uc338tgq.1 uc338tgq.1 
ENSMUST00000376562.1 ENSMUSG00000143400 ENSMUST00000376562.1 ENSMUSG00000143400 (from geneSymbol) uc338tgw.1 uc338tgw.1 
ENSMUST00000376596.1 ENSMUSG00000143401 ENSMUST00000376596.1 ENSMUSG00000143401 (from geneSymbol) uc338tie.1 uc338tie.1 
ENSMUST00000376597.1 ENSMUSG00000143402 ENSMUST00000376597.1 ENSMUSG00000143402 (from geneSymbol) uc338tif.1 uc338tif.1 
ENSMUST00000376598.1 ENSMUSG00000143403 ENSMUST00000376598.1 ENSMUSG00000143403 (from geneSymbol) uc338tig.1 uc338tig.1 
ENSMUST00000376599.1 ENSMUSG00000143404 ENSMUST00000376599.1 ENSMUSG00000143404 (from geneSymbol) uc338tih.1 uc338tih.1 
ENSMUST00000376602.1 ENSMUSG00000143405 ENSMUST00000376602.1 ENSMUSG00000143405 (from geneSymbol) uc338tik.1 uc338tik.1 
ENSMUST00000376603.1 Gm48084 ENSMUST00000376603.1 Gm48084 (from geneSymbol) uc338til.1 uc338til.1 
ENSMUST00000376606.1 ENSMUSG00000143406 ENSMUST00000376606.1 ENSMUSG00000143406 (from geneSymbol) uc338tio.1 uc338tio.1 
ENSMUST00000376607.1 ENSMUSG00000143407 ENSMUST00000376607.1 ENSMUSG00000143407 (from geneSymbol) uc338tip.1 uc338tip.1 
ENSMUST00000376608.1 ENSMUSG00000143408 ENSMUST00000376608.1 ENSMUSG00000143408 (from geneSymbol) uc338tiq.1 uc338tiq.1 
ENSMUST00000376609.1 ENSMUSG00000143409 ENSMUST00000376609.1 ENSMUSG00000143409 (from geneSymbol) uc338tir.1 uc338tir.1 
ENSMUST00000376618.1 ENSMUSG00000143410 ENSMUST00000376618.1 ENSMUSG00000143410 (from geneSymbol) uc338tja.1 uc338tja.1 
ENSMUST00000376621.1 ENSMUSG00000143411 ENSMUST00000376621.1 ENSMUSG00000143411 (from geneSymbol) uc338tjd.1 uc338tjd.1 
ENSMUST00000376624.1 ENSMUSG00000143412 ENSMUST00000376624.1 ENSMUSG00000143412 (from geneSymbol) uc338tjg.1 uc338tjg.1 
ENSMUST00000376626.1 ENSMUSG00000121350 ENSMUST00000376626.1 ENSMUSG00000121350 (from geneSymbol) uc338tji.1 uc338tji.1 
ENSMUST00000376631.1 ENSMUSG00000143413 ENSMUST00000376631.1 ENSMUSG00000143413 (from geneSymbol) uc338tjn.1 uc338tjn.1 
ENSMUST00000376632.1 ENSMUSG00000143414 ENSMUST00000376632.1 ENSMUSG00000143414 (from geneSymbol) uc338tjo.1 uc338tjo.1 
ENSMUST00000376633.1 ENSMUSG00000143415 ENSMUST00000376633.1 ENSMUSG00000143415 (from geneSymbol) uc338tjp.1 uc338tjp.1 
ENSMUST00000376634.1 Gm33054 ENSMUST00000376634.1 Gm33054 (from geneSymbol) uc338tjq.1 uc338tjq.1 
ENSMUST00000376638.1 ENSMUSG00000143416 ENSMUST00000376638.1 ENSMUSG00000143416 (from geneSymbol) uc338tju.1 uc338tju.1 
ENSMUST00000376640.1 ENSMUSG00000143417 ENSMUST00000376640.1 ENSMUSG00000143417 (from geneSymbol) uc338tjw.1 uc338tjw.1 
ENSMUST00000376642.1 ENSMUSG00000143418 ENSMUST00000376642.1 ENSMUSG00000143418 (from geneSymbol) uc338tjy.1 uc338tjy.1 
ENSMUST00000376644.1 ENSMUSG00000143419 ENSMUST00000376644.1 ENSMUSG00000143419 (from geneSymbol) uc338tjz.1 uc338tjz.1 
ENSMUST00000376645.1 ENSMUSG00000143420 ENSMUST00000376645.1 ENSMUSG00000143420 (from geneSymbol) uc338tka.1 uc338tka.1 
ENSMUST00000376647.1 ENSMUSG00000143421 ENSMUST00000376647.1 ENSMUSG00000143421 (from geneSymbol) uc338tkc.1 uc338tkc.1 
ENSMUST00000376652.1 ENSMUSG00000143422 ENSMUST00000376652.1 ENSMUSG00000143422 (from geneSymbol) uc338tkg.1 uc338tkg.1 
ENSMUST00000376657.1 2010203P06Rik ENSMUST00000376657.1 2010203P06Rik (from geneSymbol) uc338tkl.1 uc338tkl.1 
ENSMUST00000376666.1 ENSMUSG00000143423 ENSMUST00000376666.1 ENSMUSG00000143423 (from geneSymbol) uc338tku.1 uc338tku.1 
ENSMUST00000376678.1 Gm32123 ENSMUST00000376678.1 Gm32123 (from geneSymbol) uc338tlg.1 uc338tlg.1 
ENSMUST00000376705.1 ENSMUSG00000143424 ENSMUST00000376705.1 ENSMUSG00000143424 (from geneSymbol) uc338tmh.1 uc338tmh.1 
ENSMUST00000376706.1 ENSMUSG00000143425 ENSMUST00000376706.1 ENSMUSG00000143425 (from geneSymbol) uc338tmi.1 uc338tmi.1 
ENSMUST00000376708.1 BC023105 ENSMUST00000376708.1 cDNA sequence BC023105, transcript variant 1 (from RefSeq NR_183071.1) NR_183071 uc338tmk.1 uc338tmk.1 
ENSMUST00000376709.1 ENSMUSG00000143427 ENSMUST00000376709.1 predicted pseudogene 5334 (from RefSeq NR_003648.2) NR_003648 uc338tml.1 uc338tml.1 
ENSMUST00000376712.1 Gm42980 ENSMUST00000376712.1 Gm42980 (from geneSymbol) AK145395 uc338tmo.1 uc338tmo.1 
ENSMUST00000376713.1 ENSMUSG00000143428 ENSMUST00000376713.1 ENSMUSG00000143428 (from geneSymbol) uc338tmp.1 uc338tmp.1 
ENSMUST00000376714.1 ENSMUSG00000143429 ENSMUST00000376714.1 ENSMUSG00000143429 (from geneSymbol) AK029437 uc338tmq.1 uc338tmq.1 
ENSMUST00000376749.1 ENSMUSG00000143430 ENSMUST00000376749.1 ENSMUSG00000143430 (from geneSymbol) uc338tnz.1 uc338tnz.1 
ENSMUST00000376750.1 ENSMUSG00000143431 ENSMUST00000376750.1 ENSMUSG00000143431 (from geneSymbol) uc338toa.1 uc338toa.1 
ENSMUST00000376770.1 ENSMUSG00000143432 ENSMUST00000376770.1 ENSMUSG00000143432 (from geneSymbol) uc338tou.1 uc338tou.1 
ENSMUST00000376771.1 ENSMUSG00000143433 ENSMUST00000376771.1 ENSMUSG00000143433 (from geneSymbol) uc338tov.1 uc338tov.1 
ENSMUST00000376772.1 ENSMUSG00000143434 ENSMUST00000376772.1 ENSMUSG00000143434 (from geneSymbol) uc338tow.1 uc338tow.1 
ENSMUST00000376773.1 ENSMUSG00000143435 ENSMUST00000376773.1 ENSMUSG00000143435 (from geneSymbol) uc338tox.1 uc338tox.1 
ENSMUST00000376774.1 Gm48522 ENSMUST00000376774.1 Gm48522 (from geneSymbol) uc338toy.1 uc338toy.1 
ENSMUST00000376781.1 ENSMUSG00000143436 ENSMUST00000376781.1 ENSMUSG00000143436 (from geneSymbol) uc338tpf.1 uc338tpf.1 
ENSMUST00000376785.1 ENSMUSG00000143437 ENSMUST00000376785.1 ENSMUSG00000143437 (from geneSymbol) uc338tpj.1 uc338tpj.1 
ENSMUST00000376790.1 ENSMUSG00000143439 ENSMUST00000376790.1 ENSMUSG00000143439 (from geneSymbol) uc338tpn.1 uc338tpn.1 
ENSMUST00000376796.1 ENSMUSG00000143440 ENSMUST00000376796.1 ENSMUSG00000143440 (from geneSymbol) uc338tpt.1 uc338tpt.1 
ENSMUST00000376801.1 ENSMUSG00000143442 ENSMUST00000376801.1 ENSMUSG00000143442 (from geneSymbol) uc338tpw.1 uc338tpw.1 
ENSMUST00000376802.1 ENSMUSG00000143443 ENSMUST00000376802.1 ENSMUSG00000143443 (from geneSymbol) uc338tpx.1 uc338tpx.1 
ENSMUST00000376804.1 ENSMUSG00000143444 ENSMUST00000376804.1 ENSMUSG00000143444 (from geneSymbol) uc338tpz.1 uc338tpz.1 
ENSMUST00000376807.1 ENSMUSG00000143445 ENSMUST00000376807.1 ENSMUSG00000143445 (from geneSymbol) uc338tqc.1 uc338tqc.1 
ENSMUST00000376809.1 5930411N13Rik ENSMUST00000376809.1 5930411N13Rik (from geneSymbol) uc338tqe.1 uc338tqe.1 
ENSMUST00000376811.1 ENSMUSG00000143446 ENSMUST00000376811.1 ENSMUSG00000143446 (from geneSymbol) uc338tqf.1 uc338tqf.1 
ENSMUST00000376812.1 ENSMUSG00000143447 ENSMUST00000376812.1 ENSMUSG00000143447 (from geneSymbol) uc338tqg.1 uc338tqg.1 
ENSMUST00000376814.1 ENSMUSG00000143448 ENSMUST00000376814.1 ENSMUSG00000143448 (from geneSymbol) uc338tqi.1 uc338tqi.1 
ENSMUST00000376818.1 ENSMUSG00000143449 ENSMUST00000376818.1 ENSMUSG00000143449 (from geneSymbol) uc338tqm.1 uc338tqm.1 
ENSMUST00000376819.1 ENSMUSG00000143450 ENSMUST00000376819.1 ENSMUSG00000143450 (from geneSymbol) uc338tqn.1 uc338tqn.1 
ENSMUST00000376830.1 ENSMUSG00000143451 ENSMUST00000376830.1 ENSMUSG00000143451 (from geneSymbol) uc338tqy.1 uc338tqy.1 
ENSMUST00000376831.1 ENSMUSG00000143452 ENSMUST00000376831.1 ENSMUSG00000143452 (from geneSymbol) uc338tqz.1 uc338tqz.1 
ENSMUST00000376832.1 ENSMUSG00000143453 ENSMUST00000376832.1 ENSMUSG00000143453 (from geneSymbol) uc338tra.1 uc338tra.1 
ENSMUST00000376833.1 ENSMUSG00000143454 ENSMUST00000376833.1 ENSMUSG00000143454 (from geneSymbol) uc338trb.1 uc338trb.1 
ENSMUST00000376841.1 ENSMUSG00000143455 ENSMUST00000376841.1 ENSMUSG00000143455 (from geneSymbol) uc338trj.1 uc338trj.1 
ENSMUST00000376844.1 ENSMUSG00000143456 ENSMUST00000376844.1 ENSMUSG00000143456 (from geneSymbol) uc338trm.1 uc338trm.1 
ENSMUST00000376847.1 ENSMUSG00000143457 ENSMUST00000376847.1 ENSMUSG00000143457 (from geneSymbol) uc338trp.1 uc338trp.1 
ENSMUST00000376851.1 ENSMUSG00000143458 ENSMUST00000376851.1 ENSMUSG00000143458 (from geneSymbol) uc338trt.1 uc338trt.1 
ENSMUST00000376853.1 Gm47428 ENSMUST00000376853.1 Gm47428 (from geneSymbol) uc338trv.1 uc338trv.1 
ENSMUST00000376866.1 ENSMUSG00000143459 ENSMUST00000376866.1 ENSMUSG00000143459 (from geneSymbol) uc338tsi.1 uc338tsi.1 
ENSMUST00000376872.1 ENSMUSG00000143460 ENSMUST00000376872.1 ENSMUSG00000143460 (from geneSymbol) uc338tso.1 uc338tso.1 
ENSMUST00000376873.1 ENSMUSG00000143461 ENSMUST00000376873.1 ENSMUSG00000143461 (from geneSymbol) uc338tsp.1 uc338tsp.1 
ENSMUST00000376875.1 ENSMUSG00000143463 ENSMUST00000376875.1 ENSMUSG00000143463 (from geneSymbol) uc338tsq.1 uc338tsq.1 
ENSMUST00000376877.1 ENSMUSG00000143464 ENSMUST00000376877.1 ENSMUSG00000143464 (from geneSymbol) uc338tss.1 uc338tss.1 
ENSMUST00000376881.1 ENSMUSG00000143465 ENSMUST00000376881.1 ENSMUSG00000143465 (from geneSymbol) uc338tsw.1 uc338tsw.1 
ENSMUST00000376887.1 ENSMUSG00000143466 ENSMUST00000376887.1 ENSMUSG00000143466 (from geneSymbol) uc338ttc.1 uc338ttc.1 
ENSMUST00000376888.1 ENSMUSG00000143467 ENSMUST00000376888.1 ENSMUSG00000143467 (from geneSymbol) uc338ttd.1 uc338ttd.1 
ENSMUST00000376896.1 ENSMUSG00000143468 ENSMUST00000376896.1 ENSMUSG00000143468 (from geneSymbol) uc338ttl.1 uc338ttl.1 
ENSMUST00000376897.1 ENSMUSG00000143469 ENSMUST00000376897.1 ENSMUSG00000143469 (from geneSymbol) DQ072385 uc338ttm.1 uc338ttm.1 
ENSMUST00000376913.1 ENSMUSG00000143470 ENSMUST00000376913.1 ENSMUSG00000143470 (from geneSymbol) uc338tub.1 uc338tub.1 
ENSMUST00000376914.1 ENSMUSG00000143471 ENSMUST00000376914.1 ENSMUSG00000143471 (from geneSymbol) uc338tuc.1 uc338tuc.1 
ENSMUST00000377037.1 ENSMUSG00000143473 ENSMUST00000377037.1 ENSMUSG00000143473 (from geneSymbol) uc338tud.1 uc338tud.1 
ENSMUST00000377038.1 Gm904 ENSMUST00000377038.1 Gm904 (from geneSymbol) AK131725 uc338tue.1 uc338tue.1 
ENSMUST00000377163.1 ENSMUSG00000143474 ENSMUST00000377163.1 ENSMUSG00000143474 (from geneSymbol) uc338tyz.1 uc338tyz.1 
ENSMUST00000377164.1 ENSMUSG00000143475 ENSMUST00000377164.1 ENSMUSG00000143475 (from geneSymbol) uc338tza.1 uc338tza.1 
ENSMUST00000377166.1 ENSMUSG00000143476 ENSMUST00000377166.1 ENSMUSG00000143476 (from geneSymbol) uc338tzc.1 uc338tzc.1 
ENSMUST00000377168.1 ENSMUSG00000143477 ENSMUST00000377168.1 ENSMUSG00000143477 (from geneSymbol) uc338tze.1 uc338tze.1 
ENSMUST00000377171.1 ENSMUSG00000143478 ENSMUST00000377171.1 ENSMUSG00000143478 (from geneSymbol) uc338tzh.1 uc338tzh.1 
ENSMUST00000377173.1 ENSMUSG00000143479 ENSMUST00000377173.1 ENSMUSG00000143479 (from geneSymbol) uc338tzj.1 uc338tzj.1 
ENSMUST00000377195.1 ENSMUSG00000143480 ENSMUST00000377195.1 ENSMUSG00000143480 (from geneSymbol) uc338uaf.1 uc338uaf.1 
ENSMUST00000377198.1 ENSMUSG00000143481 ENSMUST00000377198.1 ENSMUSG00000143481 (from geneSymbol) uc338uah.1 uc338uah.1 
ENSMUST00000377209.1 ENSMUSG00000143482 ENSMUST00000377209.1 ENSMUSG00000143482 (from geneSymbol) uc338uas.1 uc338uas.1 
ENSMUST00000377212.1 ENSMUSG00000143483 ENSMUST00000377212.1 ENSMUSG00000143483 (from geneSymbol) uc338uav.1 uc338uav.1 
ENSMUST00000377213.1 ENSMUSG00000143484 ENSMUST00000377213.1 ENSMUSG00000143484 (from geneSymbol) uc338uaw.1 uc338uaw.1 
ENSMUST00000377216.1 9530034E10Rik ENSMUST00000377216.1 9530034E10Rik (from geneSymbol) AK020586 uc338uaz.1 uc338uaz.1 
ENSMUST00000377220.1 ENSMUSG00000143485 ENSMUST00000377220.1 ENSMUSG00000143485 (from geneSymbol) uc338ubd.1 uc338ubd.1 
ENSMUST00000377224.1 ENSMUSG00000143486 ENSMUST00000377224.1 ENSMUSG00000143486 (from geneSymbol) uc338ubh.1 uc338ubh.1 
ENSMUST00000377229.1 ENSMUSG00000143487 ENSMUST00000377229.1 ENSMUSG00000143487 (from geneSymbol) uc338ubm.1 uc338ubm.1 
ENSMUST00000377230.1 ENSMUSG00000143488 ENSMUST00000377230.1 ENSMUSG00000143488 (from geneSymbol) uc338ubn.1 uc338ubn.1 
ENSMUST00000377233.1 ENSMUSG00000143489 ENSMUST00000377233.1 ENSMUSG00000143489 (from geneSymbol) uc338ubq.1 uc338ubq.1 
ENSMUST00000377241.1 ENSMUSG00000143490 ENSMUST00000377241.1 ENSMUSG00000143490 (from geneSymbol) uc338uby.1 uc338uby.1 
ENSMUST00000377248.1 ENSMUSG00000143491 ENSMUST00000377248.1 ENSMUSG00000143491 (from geneSymbol) uc338ucf.1 uc338ucf.1 
ENSMUST00000377251.1 ENSMUSG00000143492 ENSMUST00000377251.1 ENSMUSG00000143492 (from geneSymbol) uc338uci.1 uc338uci.1 
ENSMUST00000377268.1 ENSMUSG00000143493 ENSMUST00000377268.1 ENSMUSG00000143493 (from geneSymbol) uc338ucz.1 uc338ucz.1 
ENSMUST00000377269.1 ENSMUSG00000143494 ENSMUST00000377269.1 ENSMUSG00000143494 (from geneSymbol) uc338uda.1 uc338uda.1 
ENSMUST00000377270.1 ENSMUSG00000143495 ENSMUST00000377270.1 ENSMUSG00000143495 (from geneSymbol) AK018056 uc338udb.1 uc338udb.1 
ENSMUST00000377272.1 ENSMUSG00000143496 ENSMUST00000377272.1 ENSMUSG00000143496 (from geneSymbol) uc338udd.1 uc338udd.1 
ENSMUST00000377274.1 ENSMUSG00000143497 ENSMUST00000377274.1 ENSMUSG00000143497 (from geneSymbol) uc338udf.1 uc338udf.1 
ENSMUST00000377275.1 1700012E03Rik ENSMUST00000377275.1 1700012E03Rik (from geneSymbol) AK005901 uc338udg.1 uc338udg.1 
ENSMUST00000377276.1 ENSMUSG00000143498 ENSMUST00000377276.1 ENSMUSG00000143498 (from geneSymbol) uc338udh.1 uc338udh.1 
ENSMUST00000377277.1 ENSMUSG00000143499 ENSMUST00000377277.1 ENSMUSG00000143499 (from geneSymbol) uc338udi.1 uc338udi.1 
ENSMUST00000377279.1 ENSMUSG00000143500 ENSMUST00000377279.1 ENSMUSG00000143500 (from geneSymbol) uc338udk.1 uc338udk.1 
ENSMUST00000377282.1 Rab11fip4os2 ENSMUST00000377282.1 Rab11fip4os2 (from geneSymbol) AK019731 uc338udn.1 uc338udn.1 
ENSMUST00000377298.1 1700003C15Rik ENSMUST00000377298.1 1700003C15Rik (from geneSymbol) AK077204 uc338ued.1 uc338ued.1 
ENSMUST00000377309.1 4921522P10Rik ENSMUST00000377309.1 4921522P10Rik (from geneSymbol) AK014948 uc338ueo.1 uc338ueo.1 
ENSMUST00000377312.1 ENSMUSG00000143501 ENSMUST00000377312.1 ENSMUSG00000143501 (from geneSymbol) uc338uer.1 uc338uer.1 
ENSMUST00000377313.1 ENSMUSG00000143502 ENSMUST00000377313.1 ENSMUSG00000143502 (from geneSymbol) uc338ues.1 uc338ues.1 
ENSMUST00000377314.1 ENSMUSG00000143503 ENSMUST00000377314.1 ENSMUSG00000143503 (from geneSymbol) uc338uet.1 uc338uet.1 
ENSMUST00000377322.1 ENSMUSG00000143505 ENSMUST00000377322.1 ENSMUSG00000143505 (from geneSymbol) uc338ufa.1 uc338ufa.1 
ENSMUST00000377325.1 Gm15627 ENSMUST00000377325.1 Gm15627 (from geneSymbol) KY468071 uc338ufd.1 uc338ufd.1 
ENSMUST00000377335.1 Gm57409 ENSMUST00000377335.1 Gm57409 (from geneSymbol) uc338ufn.1 uc338ufn.1 
ENSMUST00000377336.1 C130036L24Rik ENSMUST00000377336.1 C130036L24Rik (from geneSymbol) AK030799 uc338ufo.1 uc338ufo.1 
ENSMUST00000377346.1 ENSMUSG00000143506 ENSMUST00000377346.1 ENSMUSG00000143506 (from geneSymbol) uc338ufy.1 uc338ufy.1 
ENSMUST00000377370.1 ENSMUSG00000143507 ENSMUST00000377370.1 ENSMUSG00000143507 (from geneSymbol) uc338ugt.1 uc338ugt.1 
ENSMUST00000377371.1 ENSMUSG00000143508 ENSMUST00000377371.1 ENSMUSG00000143508 (from geneSymbol) uc338ugu.1 uc338ugu.1 
ENSMUST00000377375.1 ENSMUSG00000143509 ENSMUST00000377375.1 ENSMUSG00000143509 (from geneSymbol) uc338ugy.1 uc338ugy.1 
ENSMUST00000377391.1 ENSMUSG00000143510 ENSMUST00000377391.1 ENSMUSG00000143510 (from geneSymbol) uc338uho.1 uc338uho.1 
ENSMUST00000377398.1 1700007F19Rik ENSMUST00000377398.1 1700007F19Rik (from geneSymbol) AK005707 uc338uhv.1 uc338uhv.1 
ENSMUST00000377521.1 ENSMUSG00000143511 ENSMUST00000377521.1 ENSMUSG00000143511 (from geneSymbol) uc338umo.1 uc338umo.1 
ENSMUST00000377522.1 ENSMUSG00000143512 ENSMUST00000377522.1 ENSMUSG00000143512 (from geneSymbol) uc338ump.1 uc338ump.1 
ENSMUST00000377525.1 ENSMUSG00000143513 ENSMUST00000377525.1 ENSMUSG00000143513 (from geneSymbol) uc338ums.1 uc338ums.1 
ENSMUST00000377532.1 2410124H12Rik ENSMUST00000377532.1 2410124H12Rik (from geneSymbol) AK010774 uc338umz.1 uc338umz.1 
ENSMUST00000377548.1 ENSMUSG00000143515 ENSMUST00000377548.1 ENSMUSG00000143515 (from geneSymbol) uc338unl.1 uc338unl.1 
ENSMUST00000377549.1 ENSMUSG00000143516 ENSMUST00000377549.1 ENSMUSG00000143516 (from geneSymbol) uc338unm.1 uc338unm.1 
ENSMUST00000377550.1 ENSMUSG00000143517 ENSMUST00000377550.1 ENSMUSG00000143517 (from geneSymbol) uc338unn.1 uc338unn.1 
ENSMUST00000377551.1 ENSMUSG00000143518 ENSMUST00000377551.1 ENSMUSG00000143518 (from geneSymbol) uc338uno.1 uc338uno.1 
ENSMUST00000377553.1 ENSMUSG00000143519 ENSMUST00000377553.1 ENSMUSG00000143519 (from geneSymbol) uc338unq.1 uc338unq.1 
ENSMUST00000377557.1 ENSMUSG00000143520 ENSMUST00000377557.1 ENSMUSG00000143520 (from geneSymbol) uc338unu.1 uc338unu.1 
ENSMUST00000377561.1 ENSMUSG00000143521 ENSMUST00000377561.1 ENSMUSG00000143521 (from geneSymbol) uc338uny.1 uc338uny.1 
ENSMUST00000377564.1 ENSMUSG00000143522 ENSMUST00000377564.1 ENSMUSG00000143522 (from geneSymbol) uc338uob.1 uc338uob.1 
ENSMUST00000377578.1 ENSMUSG00000143523 ENSMUST00000377578.1 ENSMUSG00000143523 (from geneSymbol) uc338uop.1 uc338uop.1 
ENSMUST00000377589.1 ENSMUSG00000143524 ENSMUST00000377589.1 ENSMUSG00000143524 (from geneSymbol) uc338upa.1 uc338upa.1 
ENSMUST00000377596.1 Gm57223 ENSMUST00000377596.1 Gm57223 (from geneSymbol) uc338uph.1 uc338uph.1 
ENSMUST00000377606.1 ENSMUSG00000143525 ENSMUST00000377606.1 ENSMUSG00000143525 (from geneSymbol) uc338upr.1 uc338upr.1 
ENSMUST00000377607.1 ENSMUSG00000143526 ENSMUST00000377607.1 ENSMUSG00000143526 (from geneSymbol) uc338ups.1 uc338ups.1 
ENSMUST00000377612.1 ENSMUSG00000143527 ENSMUST00000377612.1 ENSMUSG00000143527 (from geneSymbol) uc338upx.1 uc338upx.1 
ENSMUST00000377616.1 ENSMUSG00000143528 ENSMUST00000377616.1 ENSMUSG00000143528 (from geneSymbol) uc338uqb.1 uc338uqb.1 
ENSMUST00000377617.1 Gm56835 ENSMUST00000377617.1 Gm56835 (from geneSymbol) uc338uqc.1 uc338uqc.1 
ENSMUST00000377623.1 ENSMUSG00000143529 ENSMUST00000377623.1 ENSMUSG00000143529 (from geneSymbol) uc338uqi.1 uc338uqi.1 
ENSMUST00000377625.1 ENSMUSG00000143530 ENSMUST00000377625.1 ENSMUSG00000143530 (from geneSymbol) uc338uqk.1 uc338uqk.1 
ENSMUST00000377630.1 Gm29336 ENSMUST00000377630.1 Gm29336 (from geneSymbol) uc338uqp.1 uc338uqp.1 
ENSMUST00000377636.1 Gm12150 ENSMUST00000377636.1 Gm12150 (from geneSymbol) uc338uqv.1 uc338uqv.1 
ENSMUST00000377647.1 ENSMUSG00000143531 ENSMUST00000377647.1 ENSMUSG00000143531 (from geneSymbol) uc338urg.1 uc338urg.1 
ENSMUST00000377648.1 ENSMUSG00000143532 ENSMUST00000377648.1 ENSMUSG00000143532 (from geneSymbol) uc338urh.1 uc338urh.1 
ENSMUST00000377650.1 ENSMUSG00000143533 ENSMUST00000377650.1 ENSMUSG00000143533 (from geneSymbol) uc338urj.1 uc338urj.1 
ENSMUST00000377651.1 ENSMUSG00000143534 ENSMUST00000377651.1 ENSMUSG00000143534 (from geneSymbol) uc338urk.1 uc338urk.1 
ENSMUST00000377652.1 ENSMUSG00000143535 ENSMUST00000377652.1 ENSMUSG00000143535 (from geneSymbol) uc338url.1 uc338url.1 
ENSMUST00000377656.1 Gm34047 ENSMUST00000377656.1 Gm34047 (from geneSymbol) AK086288 uc338urp.1 uc338urp.1 
ENSMUST00000377660.1 ENSMUSG00000143536 ENSMUST00000377660.1 ENSMUSG00000143536 (from geneSymbol) AK009996 uc338urt.1 uc338urt.1 
ENSMUST00000377661.1 ENSMUSG00000143537 ENSMUST00000377661.1 ENSMUSG00000143537 (from geneSymbol) AK134933 uc338uru.1 uc338uru.1 
ENSMUST00000377667.1 BC065397 ENSMUST00000377667.1 BC065397 (from geneSymbol) AK142310 uc338usa.1 uc338usa.1 
ENSMUST00000377693.1 ENSMUSG00000143538 ENSMUST00000377693.1 ENSMUSG00000143538 (from geneSymbol) uc338uta.1 uc338uta.1 
ENSMUST00000377696.1 ENSMUSG00000143539 ENSMUST00000377696.1 ENSMUSG00000143539 (from geneSymbol) uc338utd.1 uc338utd.1 
ENSMUST00000377697.1 ENSMUSG00000143540 ENSMUST00000377697.1 ENSMUSG00000143540 (from geneSymbol) uc338ute.1 uc338ute.1 
ENSMUST00000377698.1 ENSMUSG00000143541 ENSMUST00000377698.1 ENSMUSG00000143541 (from geneSymbol) uc338utf.1 uc338utf.1 
ENSMUST00000377699.1 1700048F04Rik ENSMUST00000377699.1 1700048F04Rik (from geneSymbol) AK006725 uc338utg.1 uc338utg.1 
ENSMUST00000377709.1 ENSMUSG00000143543 ENSMUST00000377709.1 ENSMUSG00000143543 (from geneSymbol) uc338utp.1 uc338utp.1 
ENSMUST00000377711.1 ENSMUSG00000143544 ENSMUST00000377711.1 ENSMUSG00000143544 (from geneSymbol) uc338utr.1 uc338utr.1 
ENSMUST00000377723.1 Gm13773 ENSMUST00000377723.1 Gm13773 (from geneSymbol) uc338uud.1 uc338uud.1 
ENSMUST00000377733.1 ENSMUSG00000143545 ENSMUST00000377733.1 ENSMUSG00000143545 (from geneSymbol) uc338uun.1 uc338uun.1 
ENSMUST00000377734.1 ENSMUSG00000143546 ENSMUST00000377734.1 ENSMUSG00000143546 (from geneSymbol) uc338uuo.1 uc338uuo.1 
ENSMUST00000377748.1 ENSMUSG00000143547 ENSMUST00000377748.1 ENSMUSG00000143547 (from geneSymbol) uc338uvc.1 uc338uvc.1 
ENSMUST00000377752.1 ENSMUSG00000143548 ENSMUST00000377752.1 ENSMUSG00000143548 (from geneSymbol) AK136722 uc338uvg.1 uc338uvg.1 
ENSMUST00000377755.1 ENSMUSG00000143549 ENSMUST00000377755.1 ENSMUSG00000143549 (from geneSymbol) uc338uvj.1 uc338uvj.1 
ENSMUST00000377757.1 ENSMUSG00000143550 ENSMUST00000377757.1 ENSMUSG00000143550 (from geneSymbol) uc338uvl.1 uc338uvl.1 
ENSMUST00000377759.1 ENSMUSG00000143551 ENSMUST00000377759.1 ENSMUSG00000143551 (from geneSymbol) uc338uvn.1 uc338uvn.1 
ENSMUST00000377760.1 ENSMUSG00000143552 ENSMUST00000377760.1 ENSMUSG00000143552 (from geneSymbol) uc338uvo.1 uc338uvo.1 
ENSMUST00000377763.1 D830032E09Rik ENSMUST00000377763.1 D830032E09Rik (from geneSymbol) AK081398 uc338uvr.1 uc338uvr.1 
ENSMUST00000377855.1 ENSMUSG00000143554 ENSMUST00000377855.1 ENSMUSG00000143554 (from geneSymbol) uc338uzc.1 uc338uzc.1 
ENSMUST00000377859.1 ENSMUSG00000143555 ENSMUST00000377859.1 ENSMUSG00000143555 (from geneSymbol) uc338uzg.1 uc338uzg.1 
ENSMUST00000377860.1 C78283 ENSMUST00000377860.1 C78283 (from geneSymbol) AK144862 uc338uzh.1 uc338uzh.1 
ENSMUST00000377871.1 ENSMUSG00000143556 ENSMUST00000377871.1 ENSMUSG00000143556 (from geneSymbol) uc338uzs.1 uc338uzs.1 
ENSMUST00000377872.1 ENSMUSG00000143557 ENSMUST00000377872.1 ENSMUSG00000143557 (from geneSymbol) uc338uzt.1 uc338uzt.1 
ENSMUST00000377878.1 ENSMUSG00000143558 ENSMUST00000377878.1 ENSMUSG00000143558 (from geneSymbol) uc338uzz.1 uc338uzz.1 
ENSMUST00000377887.1 ENSMUSG00000143559 ENSMUST00000377887.1 ENSMUSG00000143559 (from geneSymbol) uc338vai.1 uc338vai.1 
ENSMUST00000377888.1 ENSMUSG00000143560 ENSMUST00000377888.1 ENSMUSG00000143560 (from geneSymbol) uc338vaj.1 uc338vaj.1 
ENSMUST00000377889.1 Gm56801 ENSMUST00000377889.1 Gm56801 (from geneSymbol) uc338vak.1 uc338vak.1 
ENSMUST00000377894.1 ENSMUSG00000143561 ENSMUST00000377894.1 ENSMUSG00000143561 (from geneSymbol) uc338vap.1 uc338vap.1 
ENSMUST00000377895.1 ENSMUSG00000143562 ENSMUST00000377895.1 ENSMUSG00000143562 (from geneSymbol) uc338vaq.1 uc338vaq.1 
ENSMUST00000377935.1 ENSMUSG00000143563 ENSMUST00000377935.1 ENSMUSG00000143563 (from geneSymbol) uc338vce.1 uc338vce.1 
ENSMUST00000377936.1 ENSMUSG00000143564 ENSMUST00000377936.1 ENSMUSG00000143564 (from geneSymbol) uc338vcf.1 uc338vcf.1 
ENSMUST00000377937.1 Gm49256 ENSMUST00000377937.1 Gm49256 (from geneSymbol) uc338vcg.1 uc338vcg.1 
ENSMUST00000377938.1 ENSMUSG00000143565 ENSMUST00000377938.1 ENSMUSG00000143565 (from geneSymbol) uc338vch.1 uc338vch.1 
ENSMUST00000377939.1 Gm38632 ENSMUST00000377939.1 Gm38632 (from geneSymbol) uc338vci.1 uc338vci.1 
ENSMUST00000377940.1 ENSMUSG00000143566 ENSMUST00000377940.1 ENSMUSG00000143566 (from geneSymbol) uc338vcj.1 uc338vcj.1 
ENSMUST00000377941.1 ENSMUSG00000143567 ENSMUST00000377941.1 ENSMUSG00000143567 (from geneSymbol) uc338vck.1 uc338vck.1 
ENSMUST00000377942.1 ENSMUSG00000143568 ENSMUST00000377942.1 ENSMUSG00000143568 (from geneSymbol) uc338vcl.1 uc338vcl.1 
ENSMUST00000377943.1 ENSMUSG00000143569 ENSMUST00000377943.1 ENSMUSG00000143569 (from geneSymbol) uc338vcm.1 uc338vcm.1 
ENSMUST00000377945.1 ENSMUSG00000143570 ENSMUST00000377945.1 ENSMUSG00000143570 (from geneSymbol) uc338vco.1 uc338vco.1 
ENSMUST00000377946.1 ENSMUSG00000143571 ENSMUST00000377946.1 ENSMUSG00000143571 (from geneSymbol) uc338vcp.1 uc338vcp.1 
ENSMUST00000377949.1 ENSMUSG00000143572 ENSMUST00000377949.1 ENSMUSG00000143572 (from geneSymbol) uc338vcs.1 uc338vcs.1 
ENSMUST00000377959.1 ENSMUSG00000143573 ENSMUST00000377959.1 ENSMUSG00000143573 (from geneSymbol) uc338vdc.1 uc338vdc.1 
ENSMUST00000377965.1 ENSMUSG00000143574 ENSMUST00000377965.1 ENSMUSG00000143574 (from geneSymbol) uc338vdi.1 uc338vdi.1 
ENSMUST00000377966.1 Gm57388 ENSMUST00000377966.1 Gm57388 (from geneSymbol) uc338vdj.1 uc338vdj.1 
ENSMUST00000377968.1 ENSMUSG00000143575 ENSMUST00000377968.1 ENSMUSG00000143575 (from geneSymbol) uc338vdl.1 uc338vdl.1 
ENSMUST00000377970.1 ENSMUSG00000143576 ENSMUST00000377970.1 ENSMUSG00000143576 (from geneSymbol) uc338vdn.1 uc338vdn.1 
ENSMUST00000377974.1 ENSMUSG00000143577 ENSMUST00000377974.1 ENSMUSG00000143577 (from geneSymbol) uc338vdr.1 uc338vdr.1 
ENSMUST00000377977.1 ENSMUSG00000143578 ENSMUST00000377977.1 ENSMUSG00000143578 (from geneSymbol) AK134877 uc338vdu.1 uc338vdu.1 
ENSMUST00000377978.1 ENSMUSG00000143579 ENSMUST00000377978.1 ENSMUSG00000143579 (from geneSymbol) uc338vdv.1 uc338vdv.1 
ENSMUST00000377985.1 1700123O21Rik ENSMUST00000377985.1 1700123O21Rik (from geneSymbol) AK006584 uc338vdw.1 uc338vdw.1 
ENSMUST00000378003.1 ENSMUSG00000143580 ENSMUST00000378003.1 ENSMUSG00000143580 (from geneSymbol) uc338veg.1 uc338veg.1 
ENSMUST00000378004.1 ENSMUSG00000143581 ENSMUST00000378004.1 ENSMUSG00000143581 (from geneSymbol) uc338veh.1 uc338veh.1 
ENSMUST00000378007.1 ENSMUSG00000143582 ENSMUST00000378007.1 ENSMUSG00000143582 (from geneSymbol) uc338vek.1 uc338vek.1 
ENSMUST00000378009.1 ENSMUSG00000143583 ENSMUST00000378009.1 ENSMUSG00000143583 (from geneSymbol) uc338vem.1 uc338vem.1 
ENSMUST00000378013.1 ENSMUSG00000143584 ENSMUST00000378013.1 ENSMUSG00000143584 (from geneSymbol) uc338veq.1 uc338veq.1 
ENSMUST00000378014.1 ENSMUSG00000143585 ENSMUST00000378014.1 ENSMUSG00000143585 (from geneSymbol) uc338ver.1 uc338ver.1 
ENSMUST00000378016.1 ENSMUSG00000143586 ENSMUST00000378016.1 ENSMUSG00000143586 (from geneSymbol) uc338vet.1 uc338vet.1 
ENSMUST00000378017.1 Gm49494 ENSMUST00000378017.1 Gm49494 (from geneSymbol) uc338veu.1 uc338veu.1 
ENSMUST00000378046.1 ENSMUSG00000143587 ENSMUST00000378046.1 ENSMUSG00000143587 (from geneSymbol) uc338vfx.1 uc338vfx.1 
ENSMUST00000378047.1 ENSMUSG00000143588 ENSMUST00000378047.1 ENSMUSG00000143588 (from geneSymbol) uc338vfy.1 uc338vfy.1 
ENSMUST00000378050.1 ENSMUSG00000143589 ENSMUST00000378050.1 ENSMUSG00000143589 (from geneSymbol) uc338vgb.1 uc338vgb.1 
ENSMUST00000378054.1 ENSMUSG00000143590 ENSMUST00000378054.1 ENSMUSG00000143590 (from geneSymbol) uc338vgf.1 uc338vgf.1 
ENSMUST00000378055.1 ENSMUSG00000143591 ENSMUST00000378055.1 ENSMUSG00000143591 (from geneSymbol) uc338vgg.1 uc338vgg.1 
ENSMUST00000378059.1 ENSMUSG00000143592 ENSMUST00000378059.1 ENSMUSG00000143592 (from geneSymbol) uc338vgk.1 uc338vgk.1 
ENSMUST00000378062.1 ENSMUSG00000143593 ENSMUST00000378062.1 ENSMUSG00000143593 (from geneSymbol) uc338vgn.1 uc338vgn.1 
ENSMUST00000378063.1 ENSMUSG00000143594 ENSMUST00000378063.1 ENSMUSG00000143594 (from geneSymbol) uc338vgo.1 uc338vgo.1 
ENSMUST00000378066.1 ENSMUSG00000143596 ENSMUST00000378066.1 ENSMUSG00000143596 (from geneSymbol) uc338vgq.1 uc338vgq.1 
ENSMUST00000378070.1 Gm45580 ENSMUST00000378070.1 Gm45580 (from geneSymbol) uc338vgu.1 uc338vgu.1 
ENSMUST00000378072.1 ENSMUSG00000143597 ENSMUST00000378072.1 ENSMUSG00000143597 (from geneSymbol) uc338vgw.1 uc338vgw.1 
ENSMUST00000378075.1 9530026P05Rik ENSMUST00000378075.1 9530026P05Rik (from geneSymbol) AK044653 uc338vgz.1 uc338vgz.1 
ENSMUST00000378131.1 ENSMUSG00000143598 ENSMUST00000378131.1 ENSMUSG00000143598 (from geneSymbol) uc338vjc.1 uc338vjc.1 
ENSMUST00000378133.1 ENSMUSG00000143599 ENSMUST00000378133.1 ENSMUSG00000143599 (from geneSymbol) uc338vje.1 uc338vje.1 
ENSMUST00000378134.1 ENSMUSG00000143600 ENSMUST00000378134.1 ENSMUSG00000143600 (from geneSymbol) uc338vjf.1 uc338vjf.1 
ENSMUST00000378135.1 ENSMUSG00000143601 ENSMUST00000378135.1 ENSMUSG00000143601 (from geneSymbol) uc338vjg.1 uc338vjg.1 
ENSMUST00000378136.1 ENSMUSG00000143602 ENSMUST00000378136.1 ENSMUSG00000143602 (from geneSymbol) uc338vjh.1 uc338vjh.1 
ENSMUST00000378149.1 ENSMUSG00000143603 ENSMUST00000378149.1 ENSMUSG00000143603 (from geneSymbol) uc338vjl.1 uc338vjl.1 
ENSMUST00000378151.1 ENSMUSG00000143604 ENSMUST00000378151.1 ENSMUSG00000143604 (from geneSymbol) AK090289 uc338vjn.1 uc338vjn.1 
ENSMUST00000378152.1 ENSMUSG00000143605 ENSMUST00000378152.1 ENSMUSG00000143605 (from geneSymbol) uc338vjo.1 uc338vjo.1 
ENSMUST00000378155.1 ENSMUSG00000143606 ENSMUST00000378155.1 ENSMUSG00000143606 (from geneSymbol) uc338vjr.1 uc338vjr.1 
ENSMUST00000378157.1 ENSMUSG00000143608 ENSMUST00000378157.1 ENSMUSG00000143608 (from geneSymbol) uc338vjs.1 uc338vjs.1 
ENSMUST00000378162.1 ENSMUSG00000143609 ENSMUST00000378162.1 ENSMUSG00000143609 (from geneSymbol) uc338vjx.1 uc338vjx.1 
ENSMUST00000378163.1 ENSMUSG00000143610 ENSMUST00000378163.1 ENSMUSG00000143610 (from geneSymbol) uc338vjy.1 uc338vjy.1 
ENSMUST00000378164.1 ENSMUSG00000143611 ENSMUST00000378164.1 ENSMUSG00000143611 (from geneSymbol) uc338vjz.1 uc338vjz.1 
ENSMUST00000378165.1 ENSMUSG00000143612 ENSMUST00000378165.1 ENSMUSG00000143612 (from geneSymbol) uc338vka.1 uc338vka.1 
ENSMUST00000378166.1 ENSMUSG00000143613 ENSMUST00000378166.1 ENSMUSG00000143613 (from geneSymbol) uc338vkb.1 uc338vkb.1 
ENSMUST00000378171.1 ENSMUSG00000143614 ENSMUST00000378171.1 ENSMUSG00000143614 (from geneSymbol) uc338vkg.1 uc338vkg.1 
ENSMUST00000378172.1 ENSMUSG00000143615 ENSMUST00000378172.1 ENSMUSG00000143615 (from geneSymbol) uc338vkh.1 uc338vkh.1 
ENSMUST00000378174.1 0610043K17Rik ENSMUST00000378174.1 0610043K17Rik (from geneSymbol) AK002929 uc338vkj.1 uc338vkj.1 
ENSMUST00000378200.1 ENSMUSG00000143616 ENSMUST00000378200.1 ENSMUSG00000143616 (from geneSymbol) AK132964 uc338vlj.1 uc338vlj.1 
ENSMUST00000378205.1 ENSMUSG00000143617 ENSMUST00000378205.1 ENSMUSG00000143617 (from geneSymbol) uc338vlo.1 uc338vlo.1 
ENSMUST00000378206.1 ENSMUSG00000143618 ENSMUST00000378206.1 ENSMUSG00000143618 (from geneSymbol) uc338vlp.1 uc338vlp.1 
ENSMUST00000378209.1 ENSMUSG00000143619 ENSMUST00000378209.1 ENSMUSG00000143619 (from geneSymbol) uc338vls.1 uc338vls.1 
ENSMUST00000378216.1 ENSMUSG00000143620 ENSMUST00000378216.1 ENSMUSG00000143620 (from geneSymbol) uc338vlz.1 uc338vlz.1 
ENSMUST00000378218.1 ENSMUSG00000143621 ENSMUST00000378218.1 ENSMUSG00000143621 (from geneSymbol) uc338vmb.1 uc338vmb.1 
ENSMUST00000378219.1 ENSMUSG00000143622 ENSMUST00000378219.1 ENSMUSG00000143622 (from geneSymbol) uc338vmc.1 uc338vmc.1 
ENSMUST00000378220.1 ENSMUSG00000143623 ENSMUST00000378220.1 ENSMUSG00000143623 (from geneSymbol) uc338vmd.1 uc338vmd.1 
ENSMUST00000378227.1 ENSMUSG00000143624 ENSMUST00000378227.1 ENSMUSG00000143624 (from geneSymbol) uc338vmk.1 uc338vmk.1 
ENSMUST00000378232.1 ENSMUSG00000143625 ENSMUST00000378232.1 ENSMUSG00000143625 (from geneSymbol) uc338vmp.1 uc338vmp.1 
ENSMUST00000378236.1 ENSMUSG00000143626 ENSMUST00000378236.1 ENSMUSG00000143626 (from geneSymbol) uc338vmt.1 uc338vmt.1 
ENSMUST00000378238.1 ENSMUSG00000143627 ENSMUST00000378238.1 ENSMUSG00000143627 (from geneSymbol) uc338vmv.1 uc338vmv.1 
ENSMUST00000378239.1 ENSMUSG00000143628 ENSMUST00000378239.1 ENSMUSG00000143628 (from geneSymbol) uc338vmw.1 uc338vmw.1 
ENSMUST00000378241.1 ENSMUSG00000143629 ENSMUST00000378241.1 ENSMUSG00000143629 (from geneSymbol) uc338vmx.1 uc338vmx.1 
ENSMUST00000378243.1 ENSMUSG00000143630 ENSMUST00000378243.1 ENSMUSG00000143630 (from geneSymbol) uc338vmz.1 uc338vmz.1 
ENSMUST00000378244.1 ENSMUSG00000143631 ENSMUST00000378244.1 ENSMUSG00000143631 (from geneSymbol) uc338vna.1 uc338vna.1 
ENSMUST00000378245.1 ENSMUSG00000143632 ENSMUST00000378245.1 ENSMUSG00000143632 (from geneSymbol) uc338vnb.1 uc338vnb.1 
ENSMUST00000378247.1 ENSMUSG00000143633 ENSMUST00000378247.1 ENSMUSG00000143633 (from geneSymbol) uc338vnd.1 uc338vnd.1 
ENSMUST00000378253.1 ENSMUSG00000143634 ENSMUST00000378253.1 ENSMUSG00000143634 (from geneSymbol) uc338vnj.1 uc338vnj.1 
ENSMUST00000378258.1 ENSMUSG00000143635 ENSMUST00000378258.1 ENSMUSG00000143635 (from geneSymbol) uc338vno.1 uc338vno.1 
ENSMUST00000378259.1 ENSMUSG00000143636 ENSMUST00000378259.1 ENSMUSG00000143636 (from geneSymbol) uc338vnp.1 uc338vnp.1 
ENSMUST00000378260.1 Gm11339 ENSMUST00000378260.1 Gm11339 (from geneSymbol) uc338vnq.1 uc338vnq.1 
ENSMUST00000378267.1 ENSMUSG00000143637 ENSMUST00000378267.1 ENSMUSG00000143637 (from geneSymbol) uc338vnw.1 uc338vnw.1 
ENSMUST00000378275.1 ENSMUSG00000143638 ENSMUST00000378275.1 ENSMUSG00000143638 (from geneSymbol) uc338voe.1 uc338voe.1 
ENSMUST00000378277.1 ENSMUSG00000143639 ENSMUST00000378277.1 ENSMUSG00000143639 (from geneSymbol) LF197359 uc338vog.1 uc338vog.1 
ENSMUST00000378278.1 ENSMUSG00000143640 ENSMUST00000378278.1 ENSMUSG00000143640 (from geneSymbol) uc338voh.1 uc338voh.1 
ENSMUST00000378279.1 ENSMUSG00000143641 ENSMUST00000378279.1 ENSMUSG00000143641 (from geneSymbol) uc338voi.1 uc338voi.1 
ENSMUST00000378280.1 ENSMUSG00000143642 ENSMUST00000378280.1 ENSMUSG00000143642 (from geneSymbol) uc338voj.1 uc338voj.1 
ENSMUST00000378281.1 ENSMUSG00000143643 ENSMUST00000378281.1 ENSMUSG00000143643 (from geneSymbol) uc338vok.1 uc338vok.1 
ENSMUST00000378282.1 ENSMUSG00000143644 ENSMUST00000378282.1 ENSMUSG00000143644 (from geneSymbol) uc338vol.1 uc338vol.1 
ENSMUST00000378311.1 ENSMUSG00000143645 ENSMUST00000378311.1 ENSMUSG00000143645 (from geneSymbol) uc338vpo.1 uc338vpo.1 
ENSMUST00000378316.1 ENSMUSG00000143646 ENSMUST00000378316.1 ENSMUSG00000143646 (from geneSymbol) uc338vpt.1 uc338vpt.1 
ENSMUST00000378317.1 ENSMUSG00000143647 ENSMUST00000378317.1 ENSMUSG00000143647 (from geneSymbol) uc338vpu.1 uc338vpu.1 
ENSMUST00000378318.1 Gm53367 ENSMUST00000378318.1 Gm53367 (from geneSymbol) uc338vpv.1 uc338vpv.1 
ENSMUST00000378322.1 ENSMUSG00000143648 ENSMUST00000378322.1 ENSMUSG00000143648 (from geneSymbol) uc338vpz.1 uc338vpz.1 
ENSMUST00000378323.1 ENSMUSG00000143649 ENSMUST00000378323.1 ENSMUSG00000143649 (from geneSymbol) uc338vqa.1 uc338vqa.1 
ENSMUST00000378339.1 ENSMUSG00000143650 ENSMUST00000378339.1 ENSMUSG00000143650 (from geneSymbol) uc338vqq.1 uc338vqq.1 
ENSMUST00000378340.1 ENSMUSG00000143651 ENSMUST00000378340.1 ENSMUSG00000143651 (from geneSymbol) uc338vqr.1 uc338vqr.1 
ENSMUST00000378341.1 ENSMUSG00000143652 ENSMUST00000378341.1 ENSMUSG00000143652 (from geneSymbol) uc338vqs.1 uc338vqs.1 
ENSMUST00000378342.1 ENSMUSG00000143653 ENSMUST00000378342.1 ENSMUSG00000143653 (from geneSymbol) uc338vqt.1 uc338vqt.1 
ENSMUST00000378350.1 Gm57034 ENSMUST00000378350.1 Gm57034 (from geneSymbol) uc338vrb.1 uc338vrb.1 
ENSMUST00000378356.1 ENSMUSG00000143654 ENSMUST00000378356.1 ENSMUSG00000143654 (from geneSymbol) uc338vrh.1 uc338vrh.1 
ENSMUST00000378366.1 Gm30159 ENSMUST00000378366.1 Gm30159 (from geneSymbol) AK138837 uc338vrr.1 uc338vrr.1 
ENSMUST00000378371.1 ENSMUSG00000143655 ENSMUST00000378371.1 ENSMUSG00000143655 (from geneSymbol) uc338vrw.1 uc338vrw.1 
ENSMUST00000378372.1 ENSMUSG00000143656 ENSMUST00000378372.1 ENSMUSG00000143656 (from geneSymbol) uc338vrx.1 uc338vrx.1 
ENSMUST00000378373.1 ENSMUSG00000143657 ENSMUST00000378373.1 ENSMUSG00000143657 (from geneSymbol) uc338vry.1 uc338vry.1 
ENSMUST00000378374.1 E130102H24Rik ENSMUST00000378374.1 E130102H24Rik (from geneSymbol) AK021368 uc338vrz.1 uc338vrz.1 
ENSMUST00000378381.1 ENSMUSG00000143658 ENSMUST00000378381.1 ENSMUSG00000143658 (from geneSymbol) AK133116 uc338vsg.1 uc338vsg.1 
ENSMUST00000378382.1 ENSMUSG00000143659 ENSMUST00000378382.1 ENSMUSG00000143659 (from geneSymbol) LF194734 uc338vsh.1 uc338vsh.1 
ENSMUST00000378383.1 ENSMUSG00000143660 ENSMUST00000378383.1 ENSMUSG00000143660 (from geneSymbol) uc338vsi.1 uc338vsi.1 
ENSMUST00000378384.1 Gm46046 ENSMUST00000378384.1 predicted gene, 46046 (from RefSeq NR_168527.1) NR_168527 uc338vsj.1 uc338vsj.1 
ENSMUST00000378386.1 ENSMUSG00000143662 ENSMUST00000378386.1 ENSMUSG00000143662 (from geneSymbol) uc338vsl.1 uc338vsl.1 
ENSMUST00000378390.1 ENSMUSG00000143663 ENSMUST00000378390.1 ENSMUSG00000143663 (from geneSymbol) uc338vsp.1 uc338vsp.1 
ENSMUST00000378392.1 ENSMUSG00000143664 ENSMUST00000378392.1 ENSMUSG00000143664 (from geneSymbol) uc338vsr.1 uc338vsr.1 
ENSMUST00000378394.1 ENSMUSG00000143665 ENSMUST00000378394.1 ENSMUSG00000143665 (from geneSymbol) uc338vst.1 uc338vst.1 
ENSMUST00000378402.1 ENSMUSG00000143666 ENSMUST00000378402.1 ENSMUSG00000143666 (from geneSymbol) uc338vtb.1 uc338vtb.1 
ENSMUST00000378403.1 ENSMUSG00000143667 ENSMUST00000378403.1 ENSMUSG00000143667 (from geneSymbol) uc338vtc.1 uc338vtc.1 
ENSMUST00000378404.1 ENSMUSG00000143668 ENSMUST00000378404.1 ENSMUSG00000143668 (from geneSymbol) uc338vtd.1 uc338vtd.1 
ENSMUST00000378412.1 ENSMUSG00000143669 ENSMUST00000378412.1 ENSMUSG00000143669 (from geneSymbol) uc338vtl.1 uc338vtl.1 
ENSMUST00000378413.1 ENSMUSG00000143670 ENSMUST00000378413.1 ENSMUSG00000143670 (from geneSymbol) uc338vtm.1 uc338vtm.1 
ENSMUST00000378419.1 ENSMUSG00000143671 ENSMUST00000378419.1 ENSMUSG00000143671 (from geneSymbol) uc338vts.1 uc338vts.1 
ENSMUST00000378441.1 ENSMUSG00000143672 ENSMUST00000378441.1 ENSMUSG00000143672 (from geneSymbol) uc338vuo.1 uc338vuo.1 
ENSMUST00000378442.1 ENSMUSG00000143673 ENSMUST00000378442.1 ENSMUSG00000143673 (from geneSymbol) uc338vup.1 uc338vup.1 
ENSMUST00000378443.1 ENSMUSG00000143674 ENSMUST00000378443.1 ENSMUSG00000143674 (from geneSymbol) uc338vuq.1 uc338vuq.1 
ENSMUST00000378490.1 ENSMUSG00000143675 ENSMUST00000378490.1 ENSMUSG00000143675 (from geneSymbol) uc338vwk.1 uc338vwk.1 
ENSMUST00000378497.1 ENSMUSG00000143676 ENSMUST00000378497.1 ENSMUSG00000143676 (from geneSymbol) uc338vwr.1 uc338vwr.1 
ENSMUST00000378498.1 ENSMUSG00000143677 ENSMUST00000378498.1 ENSMUSG00000143677 (from geneSymbol) uc338vws.1 uc338vws.1 
ENSMUST00000378499.1 ENSMUSG00000143678 ENSMUST00000378499.1 ENSMUSG00000143678 (from geneSymbol) uc338vwt.1 uc338vwt.1 
ENSMUST00000378502.1 ENSMUSG00000143679 ENSMUST00000378502.1 ENSMUSG00000143679 (from geneSymbol) uc338vww.1 uc338vww.1 
ENSMUST00000378505.1 ENSMUSG00000143680 ENSMUST00000378505.1 ENSMUSG00000143680 (from geneSymbol) uc338vwz.1 uc338vwz.1 
ENSMUST00000378506.1 ENSMUSG00000143681 ENSMUST00000378506.1 ENSMUSG00000143681 (from geneSymbol) uc338vxa.1 uc338vxa.1 
ENSMUST00000378508.1 ENSMUSG00000143682 ENSMUST00000378508.1 ENSMUSG00000143682 (from geneSymbol) BC099537 uc338vxc.1 uc338vxc.1 
ENSMUST00000378509.1 Gm56872 ENSMUST00000378509.1 Gm56872 (from geneSymbol) uc338vxd.1 uc338vxd.1 
ENSMUST00000378511.1 ENSMUSG00000143683 ENSMUST00000378511.1 ENSMUSG00000143683 (from geneSymbol) uc338vxf.1 uc338vxf.1 
ENSMUST00000378513.1 4930551O13Rik ENSMUST00000378513.1 4930551O13Rik (from geneSymbol) AK016096 uc338vxh.1 uc338vxh.1 
ENSMUST00000378514.1 ENSMUSG00000143684 ENSMUST00000378514.1 ENSMUSG00000143684 (from geneSymbol) uc338vxi.1 uc338vxi.1 
ENSMUST00000378515.1 ENSMUSG00000143685 ENSMUST00000378515.1 ENSMUSG00000143685 (from geneSymbol) uc338vxj.1 uc338vxj.1 
ENSMUST00000378516.1 ENSMUSG00000143686 ENSMUST00000378516.1 ENSMUSG00000143686 (from geneSymbol) uc338vxk.1 uc338vxk.1 
ENSMUST00000378610.1 ENSMUSG00000143687 ENSMUST00000378610.1 ENSMUSG00000143687 (from geneSymbol) uc338wba.1 uc338wba.1 
ENSMUST00000378619.1 ENSMUSG00000143688 ENSMUST00000378619.1 ENSMUSG00000143688 (from geneSymbol) uc338wbj.1 uc338wbj.1 
ENSMUST00000378620.1 ENSMUSG00000143689 ENSMUST00000378620.1 ENSMUSG00000143689 (from geneSymbol) uc338wbk.1 uc338wbk.1 
ENSMUST00000378621.1 Gm33055 ENSMUST00000378621.1 Gm33055 (from geneSymbol) uc338wbl.1 uc338wbl.1 
ENSMUST00000378624.1 ENSMUSG00000143690 ENSMUST00000378624.1 ENSMUSG00000143690 (from geneSymbol) uc338wbo.1 uc338wbo.1 
ENSMUST00000378627.1 ENSMUSG00000143691 ENSMUST00000378627.1 ENSMUSG00000143691 (from geneSymbol) uc338wbr.1 uc338wbr.1 
ENSMUST00000378629.1 ENSMUSG00000143692 ENSMUST00000378629.1 ENSMUSG00000143692 (from geneSymbol) uc338wbt.1 uc338wbt.1 
ENSMUST00000378630.1 ENSMUSG00000143693 ENSMUST00000378630.1 ENSMUSG00000143693 (from geneSymbol) uc338wbu.1 uc338wbu.1 
ENSMUST00000378632.1 ENSMUSG00000143694 ENSMUST00000378632.1 ENSMUSG00000143694 (from geneSymbol) uc338wbw.1 uc338wbw.1 
ENSMUST00000378634.1 ENSMUSG00000143695 ENSMUST00000378634.1 ENSMUSG00000143695 (from geneSymbol) uc338wby.1 uc338wby.1 
ENSMUST00000378637.1 ENSMUSG00000143696 ENSMUST00000378637.1 ENSMUSG00000143696 (from geneSymbol) uc338wcb.1 uc338wcb.1 
ENSMUST00000378638.1 ENSMUSG00000143697 ENSMUST00000378638.1 ENSMUSG00000143697 (from geneSymbol) uc338wcc.1 uc338wcc.1 
ENSMUST00000378640.1 ENSMUSG00000143698 ENSMUST00000378640.1 ENSMUSG00000143698 (from geneSymbol) uc338wce.1 uc338wce.1 
ENSMUST00000378641.1 ENSMUSG00000143699 ENSMUST00000378641.1 ENSMUSG00000143699 (from geneSymbol) uc338wcf.1 uc338wcf.1 
ENSMUST00000378650.1 Gm12052 ENSMUST00000378650.1 Gm12052 (from geneSymbol) AK087392 uc338wco.1 uc338wco.1 
ENSMUST00000378651.1 ENSMUSG00000143700 ENSMUST00000378651.1 ENSMUSG00000143700 (from geneSymbol) uc338wcp.1 uc338wcp.1 
ENSMUST00000378662.1 ENSMUSG00000143701 ENSMUST00000378662.1 ENSMUSG00000143701 (from geneSymbol) uc338wda.1 uc338wda.1 
ENSMUST00000378663.1 ENSMUSG00000143702 ENSMUST00000378663.1 ENSMUSG00000143702 (from geneSymbol) uc338wdb.1 uc338wdb.1 
ENSMUST00000378665.1 ENSMUSG00000143703 ENSMUST00000378665.1 ENSMUSG00000143703 (from geneSymbol) uc338wdd.1 uc338wdd.1 
ENSMUST00000378668.1 ENSMUSG00000143704 ENSMUST00000378668.1 ENSMUSG00000143704 (from geneSymbol) uc338wdg.1 uc338wdg.1 
ENSMUST00000378672.1 ENSMUSG00000143707 ENSMUST00000378672.1 ENSMUSG00000143707 (from geneSymbol) uc338wdi.1 uc338wdi.1 
ENSMUST00000378674.1 ENSMUSG00000143708 ENSMUST00000378674.1 ENSMUSG00000143708 (from geneSymbol) AK006424 uc338wdk.1 uc338wdk.1 
ENSMUST00000378677.1 1700003M07Rik ENSMUST00000378677.1 1700003M07Rik (from geneSymbol) AK005651 uc338wdn.1 uc338wdn.1 
ENSMUST00000378695.1 ENSMUSG00000143709 ENSMUST00000378695.1 ENSMUSG00000143709 (from geneSymbol) uc338wef.1 uc338wef.1 
ENSMUST00000378696.1 ENSMUSG00000143710 ENSMUST00000378696.1 ENSMUSG00000143710 (from geneSymbol) uc338weg.1 uc338weg.1 
ENSMUST00000378699.1 ENSMUSG00000143711 ENSMUST00000378699.1 ENSMUSG00000143711 (from geneSymbol) uc338wej.1 uc338wej.1 
ENSMUST00000378701.1 Gm34078 ENSMUST00000378701.1 Gm34078 (from geneSymbol) AK029620 uc338wek.1 uc338wek.1 
ENSMUST00000378722.1 ENSMUSG00000143713 ENSMUST00000378722.1 ENSMUSG00000143713 (from geneSymbol) uc338wff.1 uc338wff.1 
ENSMUST00000378723.1 ENSMUSG00000143714 ENSMUST00000378723.1 ENSMUSG00000143714 (from geneSymbol) uc338wfg.1 uc338wfg.1 
ENSMUST00000378725.1 ENSMUSG00000143715 ENSMUST00000378725.1 ENSMUSG00000143715 (from geneSymbol) uc338wfi.1 uc338wfi.1 
ENSMUST00000378726.1 ENSMUSG00000143716 ENSMUST00000378726.1 ENSMUSG00000143716 (from geneSymbol) uc338wfj.1 uc338wfj.1 
ENSMUST00000378727.1 ENSMUSG00000143717 ENSMUST00000378727.1 ENSMUSG00000143717 (from geneSymbol) uc338wfk.1 uc338wfk.1 
ENSMUST00000378728.1 ENSMUSG00000143718 ENSMUST00000378728.1 ENSMUSG00000143718 (from geneSymbol) uc338wfl.1 uc338wfl.1 
ENSMUST00000378729.1 ENSMUSG00000143719 ENSMUST00000378729.1 ENSMUSG00000143719 (from geneSymbol) uc338wfm.1 uc338wfm.1 
ENSMUST00000378731.1 ENSMUSG00000143720 ENSMUST00000378731.1 ENSMUSG00000143720 (from geneSymbol) uc338wfo.1 uc338wfo.1 
ENSMUST00000378735.1 ENSMUSG00000143721 ENSMUST00000378735.1 ENSMUSG00000143721 (from geneSymbol) uc338wfs.1 uc338wfs.1 
ENSMUST00000378736.1 ENSMUSG00000143722 ENSMUST00000378736.1 ENSMUSG00000143722 (from geneSymbol) uc338wft.1 uc338wft.1 
ENSMUST00000378743.1 ENSMUSG00000143723 ENSMUST00000378743.1 ENSMUSG00000143723 (from geneSymbol) uc338wga.1 uc338wga.1 
ENSMUST00000378770.1 ENSMUSG00000143724 ENSMUST00000378770.1 ENSMUSG00000143724 (from geneSymbol) uc338whb.1 uc338whb.1 
ENSMUST00000378778.1 ENSMUSG00000143725 ENSMUST00000378778.1 ENSMUSG00000143725 (from geneSymbol) AK016287 uc338whj.1 uc338whj.1 
ENSMUST00000378780.1 ENSMUSG00000143726 ENSMUST00000378780.1 ENSMUSG00000143726 (from geneSymbol) uc338whl.1 uc338whl.1 
ENSMUST00000378798.1 ENSMUSG00000143727 ENSMUST00000378798.1 ENSMUSG00000143727 (from geneSymbol) uc338wid.1 uc338wid.1 
ENSMUST00000378799.1 ENSMUSG00000143728 ENSMUST00000378799.1 ENSMUSG00000143728 (from geneSymbol) uc338wie.1 uc338wie.1 
ENSMUST00000378802.1 ENSMUSG00000143729 ENSMUST00000378802.1 ENSMUSG00000143729 (from geneSymbol) uc338wih.1 uc338wih.1 
ENSMUST00000378803.1 ENSMUSG00000143730 ENSMUST00000378803.1 ENSMUSG00000143730 (from geneSymbol) uc338wii.1 uc338wii.1 
ENSMUST00000378806.1 ENSMUSG00000143731 ENSMUST00000378806.1 ENSMUSG00000143731 (from geneSymbol) uc338wil.1 uc338wil.1 
ENSMUST00000378813.1 ENSMUSG00000143732 ENSMUST00000378813.1 ENSMUSG00000143732 (from geneSymbol) uc338wis.1 uc338wis.1 
ENSMUST00000378815.1 Gm49719 ENSMUST00000378815.1 Gm49719 (from geneSymbol) uc338wiu.1 uc338wiu.1 
ENSMUST00000378816.1 Gm30725 ENSMUST00000378816.1 Gm30725 (from geneSymbol) BC030469 uc338wiv.1 uc338wiv.1 
ENSMUST00000378828.1 ENSMUSG00000143733 ENSMUST00000378828.1 ENSMUSG00000143733 (from geneSymbol) uc338wjh.1 uc338wjh.1 
ENSMUST00000378832.1 ENSMUSG00000143734 ENSMUST00000378832.1 ENSMUSG00000143734 (from geneSymbol) uc338wjl.1 uc338wjl.1 
ENSMUST00000378835.1 ENSMUSG00000143735 ENSMUST00000378835.1 ENSMUSG00000143735 (from geneSymbol) uc338wjo.1 uc338wjo.1 
ENSMUST00000378839.1 ENSMUSG00000143736 ENSMUST00000378839.1 ENSMUSG00000143736 (from geneSymbol) uc338wjs.1 uc338wjs.1 
ENSMUST00000378840.1 ENSMUSG00000143737 ENSMUST00000378840.1 ENSMUSG00000143737 (from geneSymbol) uc338wjt.1 uc338wjt.1 
ENSMUST00000378841.1 ENSMUSG00000143738 ENSMUST00000378841.1 ENSMUSG00000143738 (from geneSymbol) uc338wju.1 uc338wju.1 
ENSMUST00000378843.1 ENSMUSG00000143739 ENSMUST00000378843.1 ENSMUSG00000143739 (from geneSymbol) uc338wjw.1 uc338wjw.1 
ENSMUST00000378844.1 Gm36243 ENSMUST00000378844.1 Gm36243 (from geneSymbol) uc338wjx.1 uc338wjx.1 
ENSMUST00000378845.1 ENSMUSG00000143740 ENSMUST00000378845.1 ENSMUSG00000143740 (from geneSymbol) uc338wjy.1 uc338wjy.1 
ENSMUST00000378846.1 ENSMUSG00000143741 ENSMUST00000378846.1 ENSMUSG00000143741 (from geneSymbol) uc338wjz.1 uc338wjz.1 
ENSMUST00000378851.1 ENSMUSG00000143742 ENSMUST00000378851.1 ENSMUSG00000143742 (from geneSymbol) AK138446 uc338wke.1 uc338wke.1 
ENSMUST00000378872.1 ENSMUSG00000143743 ENSMUST00000378872.1 ENSMUSG00000143743 (from geneSymbol) uc338wkz.1 uc338wkz.1 
ENSMUST00000378874.1 ENSMUSG00000143744 ENSMUST00000378874.1 ENSMUSG00000143744 (from geneSymbol) uc338wlb.1 uc338wlb.1 
ENSMUST00000378875.1 ENSMUSG00000143745 ENSMUST00000378875.1 ENSMUSG00000143745 (from geneSymbol) uc338wlc.1 uc338wlc.1 
ENSMUST00000378876.1 ENSMUSG00000143746 ENSMUST00000378876.1 ENSMUSG00000143746 (from geneSymbol) uc338wld.1 uc338wld.1 
ENSMUST00000378877.1 Gm47128 ENSMUST00000378877.1 Gm47128 (from geneSymbol) uc338wle.1 uc338wle.1 
ENSMUST00000378880.1 ENSMUSG00000143747 ENSMUST00000378880.1 ENSMUSG00000143747 (from geneSymbol) uc338wlh.1 uc338wlh.1 
ENSMUST00000378885.1 Gm31152 ENSMUST00000378885.1 Gm31152 (from geneSymbol) AK141156 uc338wlm.1 uc338wlm.1 
ENSMUST00000378887.1 ENSMUSG00000143749 ENSMUST00000378887.1 ENSMUSG00000143749 (from geneSymbol) uc338wln.1 uc338wln.1 
ENSMUST00000378906.1 ENSMUSG00000143750 ENSMUST00000378906.1 ENSMUSG00000143750 (from geneSymbol) uc338wmg.1 uc338wmg.1 
ENSMUST00000378909.1 ENSMUSG00000143751 ENSMUST00000378909.1 ENSMUSG00000143751 (from geneSymbol) uc338wmj.1 uc338wmj.1 
ENSMUST00000378911.1 Gm46412 ENSMUST00000378911.1 Gm46412 (from geneSymbol) uc338wml.1 uc338wml.1 
ENSMUST00000378918.1 ENSMUSG00000143752 ENSMUST00000378918.1 ENSMUSG00000143752 (from geneSymbol) uc338wms.1 uc338wms.1 
ENSMUST00000378925.1 Gm34162 ENSMUST00000378925.1 Gm34162 (from geneSymbol) uc338wmz.1 uc338wmz.1 
ENSMUST00000378933.1 ENSMUSG00000143753 ENSMUST00000378933.1 ENSMUSG00000143753 (from geneSymbol) BC048665 uc338wnh.1 uc338wnh.1 
ENSMUST00000378945.1 ENSMUSG00000143754 ENSMUST00000378945.1 ENSMUSG00000143754 (from geneSymbol) uc338wnt.1 uc338wnt.1 
ENSMUST00000378947.1 ENSMUSG00000143755 ENSMUST00000378947.1 ENSMUSG00000143755 (from geneSymbol) uc338wnv.1 uc338wnv.1 
ENSMUST00000379090.1 ENSMUSG00000143756 ENSMUST00000379090.1 ENSMUSG00000143756 (from geneSymbol) uc338wth.1 uc338wth.1 
ENSMUST00000379091.1 ENSMUSG00000143757 ENSMUST00000379091.1 ENSMUSG00000143757 (from geneSymbol) uc338wti.1 uc338wti.1 
ENSMUST00000379092.1 ENSMUSG00000143758 ENSMUST00000379092.1 ENSMUSG00000143758 (from geneSymbol) uc338wtj.1 uc338wtj.1 
ENSMUST00000379102.1 ENSMUSG00000143759 ENSMUST00000379102.1 ENSMUSG00000143759 (from geneSymbol) uc338wtt.1 uc338wtt.1 
ENSMUST00000379117.1 Gm13404 ENSMUST00000379117.1 Gm13404 (from geneSymbol) uc338wui.1 uc338wui.1 
ENSMUST00000379119.1 ENSMUSG00000143760 ENSMUST00000379119.1 ENSMUSG00000143760 (from geneSymbol) uc338wuk.1 uc338wuk.1 
ENSMUST00000379123.1 ENSMUSG00000143761 ENSMUST00000379123.1 ENSMUSG00000143761 (from geneSymbol) uc338wuo.1 uc338wuo.1 
ENSMUST00000379126.1 ENSMUSG00000143762 ENSMUST00000379126.1 ENSMUSG00000143762 (from geneSymbol) uc338wur.1 uc338wur.1 
ENSMUST00000379132.1 ENSMUSG00000143763 ENSMUST00000379132.1 ENSMUSG00000143763 (from geneSymbol) uc338wux.1 uc338wux.1 
ENSMUST00000379137.1 ENSMUSG00000143764 ENSMUST00000379137.1 ENSMUSG00000143764 (from geneSymbol) uc338wvc.1 uc338wvc.1 
ENSMUST00000379138.1 Gm34961 ENSMUST00000379138.1 Gm34961 (from geneSymbol) uc338wvd.1 uc338wvd.1 
ENSMUST00000379153.1 ENSMUSG00000143765 ENSMUST00000379153.1 ENSMUSG00000143765 (from geneSymbol) uc338wvs.1 uc338wvs.1 
ENSMUST00000379156.1 Gm31036 ENSMUST00000379156.1 Gm31036 (from geneSymbol) uc338wvv.1 uc338wvv.1 
ENSMUST00000379161.1 ENSMUSG00000143766 ENSMUST00000379161.1 ENSMUSG00000143766 (from geneSymbol) uc338wwa.1 uc338wwa.1 
ENSMUST00000379162.1 ENSMUSG00000143767 ENSMUST00000379162.1 ENSMUSG00000143767 (from geneSymbol) uc338wwb.1 uc338wwb.1 
ENSMUST00000379163.1 ENSMUSG00000143768 ENSMUST00000379163.1 ENSMUSG00000143768 (from geneSymbol) uc338wwc.1 uc338wwc.1 
ENSMUST00000379164.1 Gm56700 ENSMUST00000379164.1 Gm56700 (from geneSymbol) uc338wwd.1 uc338wwd.1 
ENSMUST00000379165.1 ENSMUSG00000143769 ENSMUST00000379165.1 ENSMUSG00000143769 (from geneSymbol) uc338wwe.1 uc338wwe.1 
ENSMUST00000379184.1 ENSMUSG00000143770 ENSMUST00000379184.1 ENSMUSG00000143770 (from geneSymbol) uc338wwx.1 uc338wwx.1 
ENSMUST00000379185.1 ENSMUSG00000121662 ENSMUST00000379185.1 ENSMUSG00000121662 (from geneSymbol) uc338wwy.1 uc338wwy.1 
ENSMUST00000379188.1 ENSMUSG00000143771 ENSMUST00000379188.1 ENSMUSG00000143771 (from geneSymbol) uc338wxb.1 uc338wxb.1 
ENSMUST00000379189.1 ENSMUSG00000143772 ENSMUST00000379189.1 ENSMUSG00000143772 (from geneSymbol) uc338wxc.1 uc338wxc.1 
ENSMUST00000379190.1 ENSMUSG00000143773 ENSMUST00000379190.1 ENSMUSG00000143773 (from geneSymbol) uc338wxd.1 uc338wxd.1 
ENSMUST00000379193.1 4930412M03Rik ENSMUST00000379193.1 RIKEN cDNA 4930412M03 gene, transcript variant 2 (from RefSeq NR_164315.1) NR_164315 uc338wxg.1 uc338wxg.1 
ENSMUST00000379197.1 ENSMUSG00000143774 ENSMUST00000379197.1 ENSMUSG00000143774 (from geneSymbol) uc338wxk.1 uc338wxk.1 
ENSMUST00000379198.1 ENSMUSG00000143775 ENSMUST00000379198.1 ENSMUSG00000143775 (from geneSymbol) uc338wxl.1 uc338wxl.1 
ENSMUST00000379202.1 ENSMUSG00000143776 ENSMUST00000379202.1 ENSMUSG00000143776 (from geneSymbol) uc338wxp.1 uc338wxp.1 
ENSMUST00000379204.1 ENSMUSG00000143777 ENSMUST00000379204.1 ENSMUSG00000143777 (from geneSymbol) uc338wxr.1 uc338wxr.1 
ENSMUST00000379205.1 AI197445 ENSMUST00000379205.1 AI197445 (from geneSymbol) AK047765 uc338wxs.1 uc338wxs.1 
ENSMUST00000379215.1 ENSMUSG00000143778 ENSMUST00000379215.1 ENSMUSG00000143778 (from geneSymbol) uc338wyc.1 uc338wyc.1 
ENSMUST00000379216.1 ENSMUSG00000143779 ENSMUST00000379216.1 ENSMUSG00000143779 (from geneSymbol) uc338wyd.1 uc338wyd.1 
ENSMUST00000379218.1 ENSMUSG00000143780 ENSMUST00000379218.1 ENSMUSG00000143780 (from geneSymbol) uc338wyf.1 uc338wyf.1 
ENSMUST00000379222.1 ENSMUSG00000143781 ENSMUST00000379222.1 ENSMUSG00000143781 (from geneSymbol) uc338wyj.1 uc338wyj.1 
ENSMUST00000379224.1 ENSMUSG00000143782 ENSMUST00000379224.1 ENSMUSG00000143782 (from geneSymbol) uc338wyl.1 uc338wyl.1 
ENSMUST00000379227.1 ENSMUSG00000143783 ENSMUST00000379227.1 ENSMUSG00000143783 (from geneSymbol) uc338wyo.1 uc338wyo.1 
ENSMUST00000379243.1 ENSMUSG00000143784 ENSMUST00000379243.1 ENSMUSG00000143784 (from geneSymbol) uc338wze.1 uc338wze.1 
ENSMUST00000379244.1 ENSMUSG00000143785 ENSMUST00000379244.1 ENSMUSG00000143785 (from geneSymbol) uc338wzf.1 uc338wzf.1 
ENSMUST00000379245.1 ENSMUSG00000121413 ENSMUST00000379245.1 ENSMUSG00000121413 (from geneSymbol) uc338wzg.1 uc338wzg.1 
ENSMUST00000379248.1 ENSMUSG00000143786 ENSMUST00000379248.1 ENSMUSG00000143786 (from geneSymbol) uc338wzi.1 uc338wzi.1 
ENSMUST00000379249.1 ENSMUSG00000143787 ENSMUST00000379249.1 ENSMUSG00000143787 (from geneSymbol) uc338wzj.1 uc338wzj.1 
ENSMUST00000379250.1 ENSMUSG00000143788 ENSMUST00000379250.1 ENSMUSG00000143788 (from geneSymbol) uc338wzk.1 uc338wzk.1 
ENSMUST00000379253.1 ENSMUSG00000143789 ENSMUST00000379253.1 ENSMUSG00000143789 (from geneSymbol) uc338wzn.1 uc338wzn.1 
ENSMUST00000379255.1 ENSMUSG00000143790 ENSMUST00000379255.1 ENSMUSG00000143790 (from geneSymbol) uc338wzp.1 uc338wzp.1 
ENSMUST00000379258.1 ENSMUSG00000143791 ENSMUST00000379258.1 ENSMUSG00000143791 (from geneSymbol) uc338wzs.1 uc338wzs.1 
ENSMUST00000379263.1 ENSMUSG00000143792 ENSMUST00000379263.1 ENSMUSG00000143792 (from geneSymbol) uc338wzx.1 uc338wzx.1 
ENSMUST00000379265.1 ENSMUSG00000143793 ENSMUST00000379265.1 ENSMUSG00000143793 (from geneSymbol) uc338wzz.1 uc338wzz.1 
ENSMUST00000379267.1 Gm33151 ENSMUST00000379267.1 Gm33151 (from geneSymbol) uc338xab.1 uc338xab.1 
ENSMUST00000379277.1 ENSMUSG00000143795 ENSMUST00000379277.1 ENSMUSG00000143795 (from geneSymbol) uc338xak.1 uc338xak.1 
ENSMUST00000379280.1 ENSMUSG00000143796 ENSMUST00000379280.1 ENSMUSG00000143796 (from geneSymbol) uc338xan.1 uc338xan.1 
ENSMUST00000379287.1 ENSMUSG00000143797 ENSMUST00000379287.1 ENSMUSG00000143797 (from geneSymbol) uc338xau.1 uc338xau.1 
ENSMUST00000379288.1 ENSMUSG00000143798 ENSMUST00000379288.1 ENSMUSG00000143798 (from geneSymbol) uc338xav.1 uc338xav.1 
ENSMUST00000379290.1 ENSMUSG00000143799 ENSMUST00000379290.1 ENSMUSG00000143799 (from geneSymbol) uc338xax.1 uc338xax.1 
ENSMUST00000379298.1 ENSMUSG00000143800 ENSMUST00000379298.1 ENSMUSG00000143800 (from geneSymbol) uc338xbf.1 uc338xbf.1 
ENSMUST00000379312.1 ENSMUSG00000143801 ENSMUST00000379312.1 ENSMUSG00000143801 (from geneSymbol) uc338xbt.1 uc338xbt.1 
ENSMUST00000379331.1 Gm19866 ENSMUST00000379331.1 Gm19866 (from geneSymbol) uc338xcl.1 uc338xcl.1 
ENSMUST00000379337.1 ENSMUSG00000143802 ENSMUST00000379337.1 ENSMUSG00000143802 (from geneSymbol) uc338xcr.1 uc338xcr.1 
ENSMUST00000379338.1 Gm42538 ENSMUST00000379338.1 Gm42538 (from geneSymbol) AK006042 uc338xcs.1 uc338xcs.1 
ENSMUST00000379351.1 ENSMUSG00000143803 ENSMUST00000379351.1 ENSMUSG00000143803 (from geneSymbol) uc338xdf.1 uc338xdf.1 
ENSMUST00000379354.1 Gm27216 ENSMUST00000379354.1 Gm27216 (from geneSymbol) KY468222 uc338xdi.1 uc338xdi.1 
ENSMUST00000379388.1 ENSMUSG00000143804 ENSMUST00000379388.1 ENSMUSG00000143804 (from geneSymbol) uc338xeq.1 uc338xeq.1 
ENSMUST00000379391.1 ENSMUSG00000143805 ENSMUST00000379391.1 ENSMUSG00000143805 (from geneSymbol) uc338xet.1 uc338xet.1 
ENSMUST00000379394.1 ENSMUSG00000143806 ENSMUST00000379394.1 ENSMUSG00000143806 (from geneSymbol) uc338xew.1 uc338xew.1 
ENSMUST00000379400.1 ENSMUSG00000143807 ENSMUST00000379400.1 ENSMUSG00000143807 (from geneSymbol) uc338xfc.1 uc338xfc.1 
ENSMUST00000379401.1 ENSMUSG00000143808 ENSMUST00000379401.1 ENSMUSG00000143808 (from geneSymbol) uc338xfd.1 uc338xfd.1 
ENSMUST00000379402.1 ENSMUSG00000143809 ENSMUST00000379402.1 ENSMUSG00000143809 (from geneSymbol) uc338xfe.1 uc338xfe.1 
ENSMUST00000379405.1 ENSMUSG00000143810 ENSMUST00000379405.1 ENSMUSG00000143810 (from geneSymbol) uc338xfh.1 uc338xfh.1 
ENSMUST00000379407.1 ENSMUSG00000143811 ENSMUST00000379407.1 ENSMUSG00000143811 (from geneSymbol) uc338xfj.1 uc338xfj.1 
ENSMUST00000379408.1 ENSMUSG00000143812 ENSMUST00000379408.1 ENSMUSG00000143812 (from geneSymbol) uc338xfk.1 uc338xfk.1 
ENSMUST00000379412.1 ENSMUSG00000143813 ENSMUST00000379412.1 ENSMUSG00000143813 (from geneSymbol) uc338xfo.1 uc338xfo.1 
ENSMUST00000379413.1 ENSMUSG00000143814 ENSMUST00000379413.1 ENSMUSG00000143814 (from geneSymbol) uc338xfp.1 uc338xfp.1 
ENSMUST00000379414.1 1700024B18Rik ENSMUST00000379414.1 1700024B18Rik (from geneSymbol) AK006293 uc338xfq.1 uc338xfq.1 
ENSMUST00000379418.1 Gm26650 ENSMUST00000379418.1 Gm26650 (from geneSymbol) AK015236 uc338xfu.1 uc338xfu.1 
ENSMUST00000379432.1 Gm48913 ENSMUST00000379432.1 Gm48913 (from geneSymbol) uc338xgi.1 uc338xgi.1 
ENSMUST00000379433.1 Gm20732 ENSMUST00000379433.1 Gm20732 (from geneSymbol) KY467724 uc338xgj.1 uc338xgj.1 
ENSMUST00000379436.1 ENSMUSG00000143815 ENSMUST00000379436.1 ENSMUSG00000143815 (from geneSymbol) uc338xgm.1 uc338xgm.1 
ENSMUST00000379438.1 Gm57413 ENSMUST00000379438.1 Gm57413 (from geneSymbol) uc338xgo.1 uc338xgo.1 
ENSMUST00000379441.1 ENSMUSG00000143816 ENSMUST00000379441.1 ENSMUSG00000143816 (from geneSymbol) uc338xgr.1 uc338xgr.1 
ENSMUST00000379443.1 ENSMUSG00000143817 ENSMUST00000379443.1 ENSMUSG00000143817 (from geneSymbol) uc338xgt.1 uc338xgt.1 
ENSMUST00000379444.1 ENSMUSG00000143818 ENSMUST00000379444.1 ENSMUSG00000143818 (from geneSymbol) uc338xgu.1 uc338xgu.1 
ENSMUST00000379445.1 ENSMUSG00000143819 ENSMUST00000379445.1 ENSMUSG00000143819 (from geneSymbol) uc338xgv.1 uc338xgv.1 
ENSMUST00000379447.1 ENSMUSG00000143820 ENSMUST00000379447.1 ENSMUSG00000143820 (from geneSymbol) uc338xgx.1 uc338xgx.1 
ENSMUST00000379448.1 ENSMUSG00000143821 ENSMUST00000379448.1 ENSMUSG00000143821 (from geneSymbol) uc338xgy.1 uc338xgy.1 
ENSMUST00000379451.1 ENSMUSG00000143822 ENSMUST00000379451.1 ENSMUSG00000143822 (from geneSymbol) uc338xhb.1 uc338xhb.1 
ENSMUST00000379455.1 ENSMUSG00000143823 ENSMUST00000379455.1 ENSMUSG00000143823 (from geneSymbol) uc338xhf.1 uc338xhf.1 
ENSMUST00000379457.1 Gm13580 ENSMUST00000379457.1 Gm13580 (from geneSymbol) uc338xhh.1 uc338xhh.1 
ENSMUST00000379478.1 ENSMUSG00000143824 ENSMUST00000379478.1 ENSMUSG00000143824 (from geneSymbol) uc338xic.1 uc338xic.1 
ENSMUST00000379497.1 ENSMUSG00000143825 ENSMUST00000379497.1 ENSMUSG00000143825 (from geneSymbol) uc338xiv.1 uc338xiv.1 
ENSMUST00000379498.1 ENSMUSG00000143826 ENSMUST00000379498.1 ENSMUSG00000143826 (from geneSymbol) uc338xiw.1 uc338xiw.1 
ENSMUST00000379499.1 ENSMUSG00000143827 ENSMUST00000379499.1 ENSMUSG00000143827 (from geneSymbol) uc338xix.1 uc338xix.1 
ENSMUST00000379501.1 ENSMUSG00000143828 ENSMUST00000379501.1 ENSMUSG00000143828 (from geneSymbol) uc338xiy.1 uc338xiy.1 
ENSMUST00000379502.1 ENSMUSG00000143829 ENSMUST00000379502.1 ENSMUSG00000143829 (from geneSymbol) uc338xiz.1 uc338xiz.1 
ENSMUST00000379503.1 ENSMUSG00000143830 ENSMUST00000379503.1 ENSMUSG00000143830 (from geneSymbol) uc338xja.1 uc338xja.1 
ENSMUST00000379504.1 ENSMUSG00000143831 ENSMUST00000379504.1 ENSMUSG00000143831 (from geneSymbol) uc338xjb.1 uc338xjb.1 
ENSMUST00000379505.1 ENSMUSG00000143832 ENSMUST00000379505.1 ENSMUSG00000143832 (from geneSymbol) uc338xjc.1 uc338xjc.1 
ENSMUST00000379506.1 ENSMUSG00000143833 ENSMUST00000379506.1 ENSMUSG00000143833 (from geneSymbol) uc338xjd.1 uc338xjd.1 
ENSMUST00000379516.1 ENSMUSG00000143834 ENSMUST00000379516.1 ENSMUSG00000143834 (from geneSymbol) uc338xjn.1 uc338xjn.1 
ENSMUST00000379518.1 ENSMUSG00000143836 ENSMUST00000379518.1 ENSMUSG00000143836 (from geneSymbol) uc338xjo.1 uc338xjo.1 
ENSMUST00000379519.1 ENSMUSG00000143837 ENSMUST00000379519.1 ENSMUSG00000143837 (from geneSymbol) uc338xjp.1 uc338xjp.1 
ENSMUST00000379520.1 ENSMUSG00000143838 ENSMUST00000379520.1 ENSMUSG00000143838 (from geneSymbol) uc338xjq.1 uc338xjq.1 
ENSMUST00000379523.1 ENSMUSG00000143839 ENSMUST00000379523.1 ENSMUSG00000143839 (from geneSymbol) uc338xjt.1 uc338xjt.1 
ENSMUST00000379524.1 ENSMUSG00000143840 ENSMUST00000379524.1 ENSMUSG00000143840 (from geneSymbol) uc338xju.1 uc338xju.1 
ENSMUST00000379525.1 ENSMUSG00000143841 ENSMUST00000379525.1 ENSMUSG00000143841 (from geneSymbol) uc338xjv.1 uc338xjv.1 
ENSMUST00000379526.1 ENSMUSG00000143842 ENSMUST00000379526.1 ENSMUSG00000143842 (from geneSymbol) uc338xjw.1 uc338xjw.1 
ENSMUST00000379531.1 ENSMUSG00000143843 ENSMUST00000379531.1 ENSMUSG00000143843 (from geneSymbol) uc338xkb.1 uc338xkb.1 
ENSMUST00000379533.1 ENSMUSG00000143844 ENSMUST00000379533.1 ENSMUSG00000143844 (from geneSymbol) uc338xkd.1 uc338xkd.1 
ENSMUST00000379534.1 ENSMUSG00000143845 ENSMUST00000379534.1 ENSMUSG00000143845 (from geneSymbol) uc338xke.1 uc338xke.1 
ENSMUST00000379536.1 ENSMUSG00000143846 ENSMUST00000379536.1 ENSMUSG00000143846 (from geneSymbol) uc338xkg.1 uc338xkg.1 
ENSMUST00000379538.1 ENSMUSG00000143847 ENSMUST00000379538.1 ENSMUSG00000143847 (from geneSymbol) uc338xki.1 uc338xki.1 
ENSMUST00000379540.1 ENSMUSG00000143849 ENSMUST00000379540.1 ENSMUSG00000143849 (from geneSymbol) uc338xkj.1 uc338xkj.1 
ENSMUST00000379542.1 ENSMUSG00000143850 ENSMUST00000379542.1 ENSMUSG00000143850 (from geneSymbol) uc338xkl.1 uc338xkl.1 
ENSMUST00000379545.1 ENSMUSG00000143851 ENSMUST00000379545.1 ENSMUSG00000143851 (from geneSymbol) uc338xko.1 uc338xko.1 
ENSMUST00000379547.1 Gm20442 ENSMUST00000379547.1 Gm20442 (from geneSymbol) uc338xkq.1 uc338xkq.1 
ENSMUST00000379552.1 ENSMUSG00000143852 ENSMUST00000379552.1 ENSMUSG00000143852 (from geneSymbol) uc338xkv.1 uc338xkv.1 
ENSMUST00000379559.1 ENSMUSG00000143853 ENSMUST00000379559.1 ENSMUSG00000143853 (from geneSymbol) uc338xla.1 uc338xla.1 
ENSMUST00000379560.1 ENSMUSG00000143854 ENSMUST00000379560.1 ENSMUSG00000143854 (from geneSymbol) uc338xlb.1 uc338xlb.1 
ENSMUST00000379561.1 ENSMUSG00000143855 ENSMUST00000379561.1 ENSMUSG00000143855 (from geneSymbol) AK047713 uc338xlc.1 uc338xlc.1 
ENSMUST00000379562.1 ENSMUSG00000143856 ENSMUST00000379562.1 ENSMUSG00000143856 (from geneSymbol) uc338xld.1 uc338xld.1 
ENSMUST00000379564.1 ENSMUSG00000143857 ENSMUST00000379564.1 ENSMUSG00000143857 (from geneSymbol) AK015864 uc338xlf.1 uc338xlf.1 
ENSMUST00000379575.1 Gm34358 ENSMUST00000379575.1 Gm34358 (from geneSymbol) uc338xlq.1 uc338xlq.1 
ENSMUST00000379577.1 ENSMUSG00000143858 ENSMUST00000379577.1 ENSMUSG00000143858 (from geneSymbol) uc338xls.1 uc338xls.1 
ENSMUST00000379578.1 ENSMUSG00000143859 ENSMUST00000379578.1 ENSMUSG00000143859 (from geneSymbol) uc338xlt.1 uc338xlt.1 
ENSMUST00000379580.1 ENSMUSG00000143860 ENSMUST00000379580.1 ENSMUSG00000143860 (from geneSymbol) uc338xlv.1 uc338xlv.1 
ENSMUST00000379586.1 ENSMUSG00000143861 ENSMUST00000379586.1 ENSMUSG00000143861 (from geneSymbol) BC048001 uc338xmb.1 uc338xmb.1 
ENSMUST00000379587.1 ENSMUSG00000143862 ENSMUST00000379587.1 ENSMUSG00000143862 (from geneSymbol) uc338xmc.1 uc338xmc.1 
ENSMUST00000379590.1 ENSMUSG00000143863 ENSMUST00000379590.1 ENSMUSG00000143863 (from geneSymbol) uc338xmf.1 uc338xmf.1 
ENSMUST00000379591.1 ENSMUSG00000143864 ENSMUST00000379591.1 ENSMUSG00000143864 (from geneSymbol) uc338xmg.1 uc338xmg.1 
ENSMUST00000379601.1 ENSMUSG00000143865 ENSMUST00000379601.1 ENSMUSG00000143865 (from geneSymbol) uc338xmq.1 uc338xmq.1 
ENSMUST00000379603.1 ENSMUSG00000143866 ENSMUST00000379603.1 ENSMUSG00000143866 (from geneSymbol) uc338xms.1 uc338xms.1 
ENSMUST00000379605.1 ENSMUSG00000143867 ENSMUST00000379605.1 ENSMUSG00000143867 (from geneSymbol) uc338xmu.1 uc338xmu.1 
ENSMUST00000379609.1 ENSMUSG00000143868 ENSMUST00000379609.1 ENSMUSG00000143868 (from geneSymbol) uc338xmy.1 uc338xmy.1 
ENSMUST00000379610.1 ENSMUSG00000143869 ENSMUST00000379610.1 ENSMUSG00000143869 (from geneSymbol) uc338xmz.1 uc338xmz.1 
ENSMUST00000379613.1 ENSMUSG00000143870 ENSMUST00000379613.1 ENSMUSG00000143870 (from geneSymbol) uc338xnc.1 uc338xnc.1 
ENSMUST00000379616.1 ENSMUSG00000143871 ENSMUST00000379616.1 ENSMUSG00000143871 (from geneSymbol) uc338xnf.1 uc338xnf.1 
ENSMUST00000379617.1 ENSMUSG00000143872 ENSMUST00000379617.1 ENSMUSG00000143872 (from geneSymbol) uc338xng.1 uc338xng.1 
ENSMUST00000379620.1 Gm47398 ENSMUST00000379620.1 Gm47398 (from geneSymbol) uc338xnj.1 uc338xnj.1 
ENSMUST00000379628.1 ENSMUSG00000143873 ENSMUST00000379628.1 ENSMUSG00000143873 (from geneSymbol) uc338xnr.1 uc338xnr.1 
ENSMUST00000379629.1 ENSMUSG00000143874 ENSMUST00000379629.1 ENSMUSG00000143874 (from geneSymbol) uc338xns.1 uc338xns.1 
ENSMUST00000379630.1 ENSMUSG00000143875 ENSMUST00000379630.1 ENSMUSG00000143875 (from geneSymbol) uc338xnt.1 uc338xnt.1 
ENSMUST00000379631.1 Gm57450 ENSMUST00000379631.1 Gm57450 (from geneSymbol) AK019757 uc338xnu.1 uc338xnu.1 
ENSMUST00000379635.1 ENSMUSG00000143876 ENSMUST00000379635.1 ENSMUSG00000143876 (from geneSymbol) uc338xny.1 uc338xny.1 
ENSMUST00000379637.1 ENSMUSG00000143877 ENSMUST00000379637.1 ENSMUSG00000143877 (from geneSymbol) uc338xoa.1 uc338xoa.1 
ENSMUST00000379638.1 ENSMUSG00000143878 ENSMUST00000379638.1 ENSMUSG00000143878 (from geneSymbol) uc338xob.1 uc338xob.1 
ENSMUST00000379639.1 ENSMUSG00000143879 ENSMUST00000379639.1 ENSMUSG00000143879 (from geneSymbol) uc338xoc.1 uc338xoc.1 
ENSMUST00000379640.1 ENSMUSG00000143880 ENSMUST00000379640.1 ENSMUSG00000143880 (from geneSymbol) uc338xod.1 uc338xod.1 
ENSMUST00000379641.1 ENSMUSG00000143881 ENSMUST00000379641.1 ENSMUSG00000143881 (from geneSymbol) uc338xoe.1 uc338xoe.1 
ENSMUST00000379666.1 ENSMUSG00000143882 ENSMUST00000379666.1 ENSMUSG00000143882 (from geneSymbol) uc338xpd.1 uc338xpd.1 
ENSMUST00000379670.1 5430402O13Rik ENSMUST00000379670.1 5430402O13Rik (from geneSymbol) KY468089 uc338xph.1 uc338xph.1 
ENSMUST00000379702.1 ENSMUSG00000143883 ENSMUST00000379702.1 ENSMUSG00000143883 (from geneSymbol) uc338xqn.1 uc338xqn.1 
ENSMUST00000379703.1 ENSMUSG00000143884 ENSMUST00000379703.1 ENSMUSG00000143884 (from geneSymbol) uc338xqo.1 uc338xqo.1 
ENSMUST00000379721.1 ENSMUSG00000143885 ENSMUST00000379721.1 ENSMUSG00000143885 (from geneSymbol) uc338xrg.1 uc338xrg.1 
ENSMUST00000379722.1 ENSMUSG00000143886 ENSMUST00000379722.1 ENSMUSG00000143886 (from geneSymbol) AK145054 uc338xrh.1 uc338xrh.1 
ENSMUST00000379723.1 Gm19610 ENSMUST00000379723.1 Gm19610 (from geneSymbol) AK019057 uc338xri.1 uc338xri.1 
ENSMUST00000379730.1 ENSMUSG00000143887 ENSMUST00000379730.1 ENSMUSG00000143887 (from geneSymbol) uc338xrp.1 uc338xrp.1 
ENSMUST00000379731.1 Gm51663 ENSMUST00000379731.1 predicted gene, 51663 (from RefSeq NR_165475.1) NR_165475 uc338xrq.1 uc338xrq.1 
ENSMUST00000379732.1 ENSMUSG00000143889 ENSMUST00000379732.1 ENSMUSG00000143889 (from geneSymbol) uc338xrr.1 uc338xrr.1 
ENSMUST00000379734.1 ENSMUSG00000143890 ENSMUST00000379734.1 ENSMUSG00000143890 (from geneSymbol) uc338xrt.1 uc338xrt.1 
ENSMUST00000379740.1 Gm30605 ENSMUST00000379740.1 Gm30605 (from geneSymbol) KY468196 uc338xrz.1 uc338xrz.1 
ENSMUST00000379745.1 ENSMUSG00000143891 ENSMUST00000379745.1 ENSMUSG00000143891 (from geneSymbol) uc338xse.1 uc338xse.1 
ENSMUST00000379752.1 ENSMUSG00000143892 ENSMUST00000379752.1 ENSMUSG00000143892 (from geneSymbol) uc338xsl.1 uc338xsl.1 
ENSMUST00000379754.1 ENSMUSG00000143893 ENSMUST00000379754.1 ENSMUSG00000143893 (from geneSymbol) uc338xsn.1 uc338xsn.1 
ENSMUST00000379757.1 ENSMUSG00000143894 ENSMUST00000379757.1 ENSMUSG00000143894 (from geneSymbol) uc338xsq.1 uc338xsq.1 
ENSMUST00000379762.1 ENSMUSG00000143895 ENSMUST00000379762.1 ENSMUSG00000143895 (from geneSymbol) uc338xsv.1 uc338xsv.1 
ENSMUST00000379779.1 ENSMUSG00000143896 ENSMUST00000379779.1 ENSMUSG00000143896 (from geneSymbol) uc338xtm.1 uc338xtm.1 
ENSMUST00000379781.1 ENSMUSG00000143897 ENSMUST00000379781.1 ENSMUSG00000143897 (from geneSymbol) uc338xto.1 uc338xto.1 
ENSMUST00000379782.1 ENSMUSG00000143898 ENSMUST00000379782.1 ENSMUSG00000143898 (from geneSymbol) uc338xtp.1 uc338xtp.1 
ENSMUST00000379783.1 ENSMUSG00000143899 ENSMUST00000379783.1 ENSMUSG00000143899 (from geneSymbol) uc338xtq.1 uc338xtq.1 
ENSMUST00000379785.1 1700020D14Rik ENSMUST00000379785.1 1700020D14Rik (from geneSymbol) KC170991 uc338xts.1 uc338xts.1 
ENSMUST00000379793.1 Gm44717 ENSMUST00000379793.1 Gm44717 (from geneSymbol) uc338xua.1 uc338xua.1 
ENSMUST00000379799.1 ENSMUSG00000143900 ENSMUST00000379799.1 ENSMUSG00000143900 (from geneSymbol) uc338xug.1 uc338xug.1 
ENSMUST00000379800.1 ENSMUSG00000143901 ENSMUST00000379800.1 ENSMUSG00000143901 (from geneSymbol) uc338xuh.1 uc338xuh.1 
ENSMUST00000379801.1 ENSMUSG00000143902 ENSMUST00000379801.1 ENSMUSG00000143902 (from geneSymbol) uc338xui.1 uc338xui.1 
ENSMUST00000379805.1 1700012D16Rik ENSMUST00000379805.1 1700012D16Rik (from geneSymbol) AK005899 uc338xuk.1 uc338xuk.1 
ENSMUST00000379815.1 Gm56745 ENSMUST00000379815.1 Gm56745 (from geneSymbol) uc338xut.1 uc338xut.1 
ENSMUST00000379829.1 ENSMUSG00000143903 ENSMUST00000379829.1 ENSMUSG00000143903 (from geneSymbol) uc338xvh.1 uc338xvh.1 
ENSMUST00000379869.1 ENSMUSG00000143904 ENSMUST00000379869.1 ENSMUSG00000143904 (from geneSymbol) uc338xwv.1 uc338xwv.1 
ENSMUST00000379871.1 ENSMUSG00000143905 ENSMUST00000379871.1 ENSMUSG00000143905 (from geneSymbol) uc338xwx.1 uc338xwx.1 
ENSMUST00000379873.1 1700081H04Rik ENSMUST00000379873.1 1700081H04Rik (from geneSymbol) AK006966 uc338xwz.1 uc338xwz.1 
ENSMUST00000379899.1 ENSMUSG00000143906 ENSMUST00000379899.1 ENSMUSG00000143906 (from geneSymbol) uc338xxz.1 uc338xxz.1 
ENSMUST00000379901.1 ENSMUSG00000143907 ENSMUST00000379901.1 ENSMUSG00000143907 (from geneSymbol) AK134078 uc338xyb.1 uc338xyb.1 
ENSMUST00000379906.1 ENSMUSG00000143908 ENSMUST00000379906.1 ENSMUSG00000143908 (from geneSymbol) uc338xyg.1 uc338xyg.1 
ENSMUST00000379907.1 9130015L21Rik ENSMUST00000379907.1 9130015L21Rik (from geneSymbol) AK018627 uc338xyh.1 uc338xyh.1 
ENSMUST00000379910.1 ENSMUSG00000143909 ENSMUST00000379910.1 ENSMUSG00000143909 (from geneSymbol) uc338xyk.1 uc338xyk.1 
ENSMUST00000379913.1 ENSMUSG00000143910 ENSMUST00000379913.1 ENSMUSG00000143910 (from geneSymbol) uc338xyn.1 uc338xyn.1 
ENSMUST00000379917.1 Gm57308 ENSMUST00000379917.1 Gm57308 (from geneSymbol) uc338xyr.1 uc338xyr.1 
ENSMUST00000379960.1 ENSMUSG00000143911 ENSMUST00000379960.1 ENSMUSG00000143911 (from geneSymbol) uc338yai.1 uc338yai.1 
ENSMUST00000379965.1 ENSMUSG00000143912 ENSMUST00000379965.1 ENSMUSG00000143912 (from geneSymbol) uc338yan.1 uc338yan.1 
ENSMUST00000379987.1 ENSMUSG00000143913 ENSMUST00000379987.1 ENSMUSG00000143913 (from geneSymbol) uc338ybj.1 uc338ybj.1 
ENSMUST00000380000.1 Gm15651 ENSMUST00000380000.1 Gm15651 (from geneSymbol) uc338ybw.1 uc338ybw.1 
ENSMUST00000380006.1 ENSMUSG00000143914 ENSMUST00000380006.1 ENSMUSG00000143914 (from geneSymbol) uc338ycb.1 uc338ycb.1 
ENSMUST00000380007.1 ENSMUSG00000143915 ENSMUST00000380007.1 ENSMUSG00000143915 (from geneSymbol) uc338ycc.1 uc338ycc.1 
ENSMUST00000380009.1 ENSMUSG00000143916 ENSMUST00000380009.1 ENSMUSG00000143916 (from geneSymbol) uc338yce.1 uc338yce.1 
ENSMUST00000380010.1 ENSMUSG00000143917 ENSMUST00000380010.1 ENSMUSG00000143917 (from geneSymbol) uc338ycf.1 uc338ycf.1 
ENSMUST00000380012.1 ENSMUSG00000143918 ENSMUST00000380012.1 ENSMUSG00000143918 (from geneSymbol) uc338ych.1 uc338ych.1 
ENSMUST00000380013.1 ENSMUSG00000143919 ENSMUST00000380013.1 ENSMUSG00000143919 (from geneSymbol) uc338yci.1 uc338yci.1 
ENSMUST00000380022.1 ENSMUSG00000143920 ENSMUST00000380022.1 ENSMUSG00000143920 (from geneSymbol) uc338ycr.1 uc338ycr.1 
ENSMUST00000380023.1 ENSMUSG00000143921 ENSMUST00000380023.1 ENSMUSG00000143921 (from geneSymbol) BC040090 uc338ycs.1 uc338ycs.1 
ENSMUST00000380024.1 ENSMUSG00000143922 ENSMUST00000380024.1 ENSMUSG00000143922 (from geneSymbol) uc338yct.1 uc338yct.1 
ENSMUST00000380025.1 ENSMUSG00000143923 ENSMUST00000380025.1 ENSMUSG00000143923 (from geneSymbol) uc338ycu.1 uc338ycu.1 
ENSMUST00000380029.1 1700108J01Rik ENSMUST00000380029.1 1700108J01Rik (from geneSymbol) KY467715 uc338ycy.1 uc338ycy.1 
ENSMUST00000380042.1 Gm26608 ENSMUST00000380042.1 Gm26608 (from geneSymbol) uc338ydl.1 uc338ydl.1 
ENSMUST00000380053.1 ENSMUSG00000143924 ENSMUST00000380053.1 ENSMUSG00000143924 (from geneSymbol) uc338ydw.1 uc338ydw.1 
ENSMUST00000380054.1 ENSMUSG00000143925 ENSMUST00000380054.1 ENSMUSG00000143925 (from geneSymbol) uc338ydx.1 uc338ydx.1 
ENSMUST00000380055.1 ENSMUSG00000143926 ENSMUST00000380055.1 ENSMUSG00000143926 (from geneSymbol) AK029389 uc338ydy.1 uc338ydy.1 
ENSMUST00000380056.1 Gm11513 ENSMUST00000380056.1 Gm11513 (from geneSymbol) uc338ydz.1 uc338ydz.1 
ENSMUST00000380058.1 ENSMUSG00000143927 ENSMUST00000380058.1 ENSMUSG00000143927 (from geneSymbol) uc338yea.1 uc338yea.1 
ENSMUST00000380059.1 ENSMUSG00000143928 ENSMUST00000380059.1 ENSMUSG00000143928 (from geneSymbol) uc338yeb.1 uc338yeb.1 
ENSMUST00000380061.1 ENSMUSG00000143929 ENSMUST00000380061.1 ENSMUSG00000143929 (from geneSymbol) uc338yed.1 uc338yed.1 
ENSMUST00000380157.1 ENSMUSG00000143931 ENSMUST00000380157.1 ENSMUSG00000143931 (from geneSymbol) uc338yee.1 uc338yee.1 
ENSMUST00000380159.1 ENSMUSG00000143932 ENSMUST00000380159.1 ENSMUSG00000143932 (from geneSymbol) uc338yeg.1 uc338yeg.1 
ENSMUST00000380161.1 Gm35920 ENSMUST00000380161.1 Gm35920 (from geneSymbol) uc338yei.1 uc338yei.1 
ENSMUST00000380182.1 ENSMUSG00000143933 ENSMUST00000380182.1 ENSMUSG00000143933 (from geneSymbol) uc338yfd.1 uc338yfd.1 
ENSMUST00000380185.1 ENSMUSG00000143934 ENSMUST00000380185.1 ENSMUSG00000143934 (from geneSymbol) uc338yfg.1 uc338yfg.1 
ENSMUST00000380188.1 ENSMUSG00000143935 ENSMUST00000380188.1 ENSMUSG00000143935 (from geneSymbol) uc338yfj.1 uc338yfj.1 
ENSMUST00000380190.1 ENSMUSG00000143936 ENSMUST00000380190.1 ENSMUSG00000143936 (from geneSymbol) uc338yfl.1 uc338yfl.1 
ENSMUST00000380191.1 ENSMUSG00000143937 ENSMUST00000380191.1 ENSMUSG00000143937 (from geneSymbol) uc338yfm.1 uc338yfm.1 
ENSMUST00000380195.1 ENSMUSG00000143938 ENSMUST00000380195.1 ENSMUSG00000143938 (from geneSymbol) uc338yfq.1 uc338yfq.1 
ENSMUST00000380200.1 ENSMUSG00000143939 ENSMUST00000380200.1 ENSMUSG00000143939 (from geneSymbol) uc338yfv.1 uc338yfv.1 
ENSMUST00000380203.1 ENSMUSG00000143940 ENSMUST00000380203.1 ENSMUSG00000143940 (from geneSymbol) uc338yfy.1 uc338yfy.1 
ENSMUST00000380204.1 ENSMUSG00000143941 ENSMUST00000380204.1 ENSMUSG00000143941 (from geneSymbol) uc338yfz.1 uc338yfz.1 
ENSMUST00000380205.1 ENSMUSG00000143942 ENSMUST00000380205.1 ENSMUSG00000143942 (from geneSymbol) uc338yga.1 uc338yga.1 
ENSMUST00000380206.1 ENSMUSG00000143943 ENSMUST00000380206.1 ENSMUSG00000143943 (from geneSymbol) uc338ygb.1 uc338ygb.1 
ENSMUST00000380211.1 ENSMUSG00000143944 ENSMUST00000380211.1 ENSMUSG00000143944 (from geneSymbol) AK079403 uc338ygg.1 uc338ygg.1 
ENSMUST00000380220.1 ENSMUSG00000143946 ENSMUST00000380220.1 ENSMUSG00000143946 (from geneSymbol) uc338ygn.1 uc338ygn.1 
ENSMUST00000380221.1 ENSMUSG00000143947 ENSMUST00000380221.1 ENSMUSG00000143947 (from geneSymbol) uc338ygo.1 uc338ygo.1 
ENSMUST00000380222.1 Gm20508 ENSMUST00000380222.1 Gm20508 (from geneSymbol) uc338ygp.1 uc338ygp.1 
ENSMUST00000380231.1 ENSMUSG00000143948 ENSMUST00000380231.1 ENSMUSG00000143948 (from geneSymbol) uc338ygy.1 uc338ygy.1 
ENSMUST00000380235.1 2310034O05Rik ENSMUST00000380235.1 2310034O05Rik (from geneSymbol) AK009622 uc338yhc.1 uc338yhc.1 
ENSMUST00000380244.1 ENSMUSG00000143949 ENSMUST00000380244.1 ENSMUSG00000143949 (from geneSymbol) uc338yhl.1 uc338yhl.1 
ENSMUST00000380250.1 Gm34276 ENSMUST00000380250.1 Gm34276 (from geneSymbol) uc338yhr.1 uc338yhr.1 
ENSMUST00000380268.1 Gm57304 ENSMUST00000380268.1 Gm57304 (from geneSymbol) uc338yij.1 uc338yij.1 
ENSMUST00000380273.1 ENSMUSG00000143950 ENSMUST00000380273.1 ENSMUSG00000143950 (from geneSymbol) uc338yio.1 uc338yio.1 
ENSMUST00000380281.1 ENSMUSG00000143951 ENSMUST00000380281.1 ENSMUSG00000143951 (from geneSymbol) uc338yiw.1 uc338yiw.1 
ENSMUST00000380284.1 ENSMUSG00000143952 ENSMUST00000380284.1 ENSMUSG00000143952 (from geneSymbol) uc338yiz.1 uc338yiz.1 
ENSMUST00000380286.1 ENSMUSG00000143953 ENSMUST00000380286.1 ENSMUSG00000143953 (from geneSymbol) uc338yjb.1 uc338yjb.1 
ENSMUST00000380288.1 ENSMUSG00000143954 ENSMUST00000380288.1 ENSMUSG00000143954 (from geneSymbol) uc338yjd.1 uc338yjd.1 
ENSMUST00000380289.1 ENSMUSG00000143955 ENSMUST00000380289.1 ENSMUSG00000143955 (from geneSymbol) LF192589 uc338yje.1 uc338yje.1 
ENSMUST00000380371.1 ENSMUSG00000143956 ENSMUST00000380371.1 ENSMUSG00000143956 (from geneSymbol) uc338ymf.1 uc338ymf.1 
ENSMUST00000380372.1 ENSMUSG00000143957 ENSMUST00000380372.1 ENSMUSG00000143957 (from geneSymbol) uc338ymg.1 uc338ymg.1 
ENSMUST00000380373.1 ENSMUSG00000143958 ENSMUST00000380373.1 ENSMUSG00000143958 (from geneSymbol) uc338ymh.1 uc338ymh.1 
ENSMUST00000380376.1 ENSMUSG00000143959 ENSMUST00000380376.1 ENSMUSG00000143959 (from geneSymbol) AK008937 uc338ymk.1 uc338ymk.1 
ENSMUST00000380378.1 ENSMUSG00000143960 ENSMUST00000380378.1 ENSMUSG00000143960 (from geneSymbol) uc338ymm.1 uc338ymm.1 
ENSMUST00000380379.1 ENSMUSG00000143961 ENSMUST00000380379.1 ENSMUSG00000143961 (from geneSymbol) uc338ymn.1 uc338ymn.1 
ENSMUST00000380382.1 ENSMUSG00000143962 ENSMUST00000380382.1 ENSMUSG00000143962 (from geneSymbol) uc338ymq.1 uc338ymq.1 
ENSMUST00000380384.1 ENSMUSG00000143963 ENSMUST00000380384.1 ENSMUSG00000143963 (from geneSymbol) uc338yms.1 uc338yms.1 
ENSMUST00000380393.1 ENSMUSG00000143964 ENSMUST00000380393.1 ENSMUSG00000143964 (from geneSymbol) uc338ymu.1 uc338ymu.1 
ENSMUST00000380397.1 ENSMUSG00000143965 ENSMUST00000380397.1 ENSMUSG00000143965 (from geneSymbol) uc338ymy.1 uc338ymy.1 
ENSMUST00000380398.1 ENSMUSG00000143966 ENSMUST00000380398.1 ENSMUSG00000143966 (from geneSymbol) uc338ymz.1 uc338ymz.1 
ENSMUST00000380399.1 ENSMUSG00000143967 ENSMUST00000380399.1 ENSMUSG00000143967 (from geneSymbol) uc338yna.1 uc338yna.1 
ENSMUST00000380400.1 ENSMUSG00000143968 ENSMUST00000380400.1 ENSMUSG00000143968 (from geneSymbol) uc338ynb.1 uc338ynb.1 
ENSMUST00000380413.1 ENSMUSG00000143969 ENSMUST00000380413.1 ENSMUSG00000143969 (from geneSymbol) uc338yno.1 uc338yno.1 
ENSMUST00000380419.1 ENSMUSG00000143970 ENSMUST00000380419.1 ENSMUSG00000143970 (from geneSymbol) uc338ynu.1 uc338ynu.1 
ENSMUST00000380420.1 ENSMUSG00000143971 ENSMUST00000380420.1 ENSMUSG00000143971 (from geneSymbol) uc338ynv.1 uc338ynv.1 
ENSMUST00000380432.1 ENSMUSG00000143972 ENSMUST00000380432.1 ENSMUSG00000143972 (from geneSymbol) uc338yoh.1 uc338yoh.1 
ENSMUST00000380445.1 1700022E09Rik ENSMUST00000380445.1 1700022E09Rik (from geneSymbol) AK006237 uc338you.1 uc338you.1 
ENSMUST00000380479.1 D030025P21Rik ENSMUST00000380479.1 D030025P21Rik (from geneSymbol) uc338yqc.1 uc338yqc.1 
ENSMUST00000380480.1 ENSMUSG00000143973 ENSMUST00000380480.1 ENSMUSG00000143973 (from geneSymbol) uc338yqd.1 uc338yqd.1 
ENSMUST00000380481.1 ENSMUSG00000143974 ENSMUST00000380481.1 ENSMUSG00000143974 (from geneSymbol) uc338yqe.1 uc338yqe.1 
ENSMUST00000380482.1 ENSMUSG00000143975 ENSMUST00000380482.1 ENSMUSG00000143975 (from geneSymbol) uc338yqf.1 uc338yqf.1 
ENSMUST00000380489.1 ENSMUSG00000143976 ENSMUST00000380489.1 ENSMUSG00000143976 (from geneSymbol) uc338yqm.1 uc338yqm.1 
ENSMUST00000380497.1 ENSMUSG00000143977 ENSMUST00000380497.1 ENSMUSG00000143977 (from geneSymbol) uc338yqu.1 uc338yqu.1 
ENSMUST00000380498.1 ENSMUSG00000143978 ENSMUST00000380498.1 ENSMUSG00000143978 (from geneSymbol) uc338yqv.1 uc338yqv.1 
ENSMUST00000380499.1 ENSMUSG00000143979 ENSMUST00000380499.1 ENSMUSG00000143979 (from geneSymbol) uc338yqw.1 uc338yqw.1 
ENSMUST00000380500.1 ENSMUSG00000143980 ENSMUST00000380500.1 ENSMUSG00000143980 (from geneSymbol) uc338yqx.1 uc338yqx.1 
ENSMUST00000380505.1 ENSMUSG00000143981 ENSMUST00000380505.1 ENSMUSG00000143981 (from geneSymbol) uc338yrc.1 uc338yrc.1 
ENSMUST00000380508.1 Gm32067 ENSMUST00000380508.1 Gm32067 (from geneSymbol) uc338yrf.1 uc338yrf.1 
ENSMUST00000380519.1 ENSMUSG00000143982 ENSMUST00000380519.1 ENSMUSG00000143982 (from geneSymbol) uc338yrq.1 uc338yrq.1 
ENSMUST00000380520.1 ENSMUSG00000143983 ENSMUST00000380520.1 ENSMUSG00000143983 (from geneSymbol) uc338yrr.1 uc338yrr.1 
ENSMUST00000380521.1 ENSMUSG00000143984 ENSMUST00000380521.1 ENSMUSG00000143984 (from geneSymbol) uc338yrs.1 uc338yrs.1 
ENSMUST00000380522.1 ENSMUSG00000143985 ENSMUST00000380522.1 ENSMUSG00000143985 (from geneSymbol) uc338yrt.1 uc338yrt.1 
ENSMUST00000380523.1 4930463O16Rik ENSMUST00000380523.1 4930463O16Rik (from geneSymbol) AK015500 uc338yru.1 uc338yru.1 
ENSMUST00000380526.1 ENSMUSG00000143987 ENSMUST00000380526.1 ENSMUSG00000143987 (from geneSymbol) uc338yrw.1 uc338yrw.1 
ENSMUST00000380569.1 Prkag2os1 ENSMUST00000380569.1 Prkag2os1 (from geneSymbol) AK016926 uc338ytn.1 uc338ytn.1 
ENSMUST00000380571.1 ENSMUSG00000143988 ENSMUST00000380571.1 ENSMUSG00000143988 (from geneSymbol) uc338ytp.1 uc338ytp.1 
ENSMUST00000380574.1 ENSMUSG00000143989 ENSMUST00000380574.1 ENSMUSG00000143989 (from geneSymbol) uc338yts.1 uc338yts.1 
ENSMUST00000380576.1 ENSMUSG00000143990 ENSMUST00000380576.1 ENSMUSG00000143990 (from geneSymbol) uc338ytu.1 uc338ytu.1 
ENSMUST00000380585.1 ENSMUSG00000143991 ENSMUST00000380585.1 ENSMUSG00000143991 (from geneSymbol) LF198131 uc338yud.1 uc338yud.1 
ENSMUST00000380586.1 Gm12514 ENSMUST00000380586.1 Gm12514 (from geneSymbol) AK144643 uc338yue.1 uc338yue.1 
ENSMUST00000380653.1 ENSMUSG00000143993 ENSMUST00000380653.1 ENSMUSG00000143993 (from geneSymbol) uc338yws.1 uc338yws.1 
ENSMUST00000380654.1 ENSMUSG00000143994 ENSMUST00000380654.1 ENSMUSG00000143994 (from geneSymbol) uc338ywt.1 uc338ywt.1 
ENSMUST00000380655.1 ENSMUSG00000143995 ENSMUST00000380655.1 ENSMUSG00000143995 (from geneSymbol) uc338ywu.1 uc338ywu.1 
ENSMUST00000380656.1 ENSMUSG00000143996 ENSMUST00000380656.1 ENSMUSG00000143996 (from geneSymbol) uc338ywv.1 uc338ywv.1 
ENSMUST00000380657.1 ENSMUSG00000143997 ENSMUST00000380657.1 ENSMUSG00000143997 (from geneSymbol) uc338yww.1 uc338yww.1 
ENSMUST00000380659.1 ENSMUSG00000143998 ENSMUST00000380659.1 ENSMUSG00000143998 (from geneSymbol) uc338ywy.1 uc338ywy.1 
ENSMUST00000380662.1 ENSMUSG00000143999 ENSMUST00000380662.1 ENSMUSG00000143999 (from geneSymbol) uc338yxb.1 uc338yxb.1 
ENSMUST00000380668.1 ENSMUSG00000144000 ENSMUST00000380668.1 ENSMUSG00000144000 (from geneSymbol) uc338yxh.1 uc338yxh.1 
ENSMUST00000380669.1 ENSMUSG00000144001 ENSMUST00000380669.1 ENSMUSG00000144001 (from geneSymbol) uc338yxi.1 uc338yxi.1 
ENSMUST00000380684.1 ENSMUSG00000144002 ENSMUST00000380684.1 ENSMUSG00000144002 (from geneSymbol) uc338yxw.1 uc338yxw.1 
ENSMUST00000380686.1 ENSMUSG00000144003 ENSMUST00000380686.1 ENSMUSG00000144003 (from geneSymbol) uc338yxy.1 uc338yxy.1 
ENSMUST00000380688.1 ENSMUSG00000144004 ENSMUST00000380688.1 ENSMUSG00000144004 (from geneSymbol) uc338yya.1 uc338yya.1 
ENSMUST00000380697.1 ENSMUSG00000144005 ENSMUST00000380697.1 ENSMUSG00000144005 (from geneSymbol) uc338yyj.1 uc338yyj.1 
ENSMUST00000380698.1 ENSMUSG00000144006 ENSMUST00000380698.1 ENSMUSG00000144006 (from geneSymbol) uc338yyk.1 uc338yyk.1 
ENSMUST00000380699.1 ENSMUSG00000144007 ENSMUST00000380699.1 ENSMUSG00000144007 (from geneSymbol) uc338yyl.1 uc338yyl.1 
ENSMUST00000380700.1 ENSMUSG00000144008 ENSMUST00000380700.1 ENSMUSG00000144008 (from geneSymbol) uc338yym.1 uc338yym.1 
ENSMUST00000380703.1 ENSMUSG00000144009 ENSMUST00000380703.1 ENSMUSG00000144009 (from geneSymbol) uc338yyp.1 uc338yyp.1 
ENSMUST00000380705.1 Gm32273 ENSMUST00000380705.1 Gm32273 (from geneSymbol) uc338yyr.1 uc338yyr.1 
ENSMUST00000380722.1 ENSMUSG00000144011 ENSMUST00000380722.1 ENSMUSG00000144011 (from geneSymbol) uc338yzi.1 uc338yzi.1 
ENSMUST00000380730.1 Gm40847 ENSMUST00000380730.1 Gm40847 (from geneSymbol) BC063063 uc338yzq.1 uc338yzq.1 
ENSMUST00000380735.1 Gm35082 ENSMUST00000380735.1 Gm35082 (from geneSymbol) BC044745 uc338yzu.1 uc338yzu.1 
ENSMUST00000380736.1 ENSMUSG00000144012 ENSMUST00000380736.1 ENSMUSG00000144012 (from geneSymbol) uc338yzv.1 uc338yzv.1 
ENSMUST00000380739.1 ENSMUSG00000144013 ENSMUST00000380739.1 ENSMUSG00000144013 (from geneSymbol) uc338yzy.1 uc338yzy.1 
ENSMUST00000380740.1 ENSMUSG00000144014 ENSMUST00000380740.1 ENSMUSG00000144014 (from geneSymbol) uc338yzz.1 uc338yzz.1 
ENSMUST00000380744.1 ENSMUSG00000144015 ENSMUST00000380744.1 ENSMUSG00000144015 (from geneSymbol) uc338zad.1 uc338zad.1 
ENSMUST00000380746.1 ENSMUSG00000144016 ENSMUST00000380746.1 ENSMUSG00000144016 (from geneSymbol) AK016122 uc338zaf.1 uc338zaf.1 
ENSMUST00000380749.1 9930004E17Rik ENSMUST00000380749.1 9930004E17Rik (from geneSymbol) uc338zai.1 uc338zai.1 
ENSMUST00000380752.1 ENSMUSG00000144017 ENSMUST00000380752.1 ENSMUSG00000144017 (from geneSymbol) uc338zal.1 uc338zal.1 
ENSMUST00000380754.1 ENSMUSG00000144018 ENSMUST00000380754.1 ENSMUSG00000144018 (from geneSymbol) uc338zan.1 uc338zan.1 
ENSMUST00000380756.1 ENSMUSG00000144019 ENSMUST00000380756.1 ENSMUSG00000144019 (from geneSymbol) uc338zap.1 uc338zap.1 
ENSMUST00000380758.1 1700027A07Rik ENSMUST00000380758.1 1700027A07Rik (from geneSymbol) AK006404 uc338zaq.1 uc338zaq.1 
ENSMUST00000380759.1 ENSMUSG00000144021 ENSMUST00000380759.1 ENSMUSG00000144021 (from geneSymbol) uc338zar.1 uc338zar.1 
ENSMUST00000380760.1 ENSMUSG00000144022 ENSMUST00000380760.1 ENSMUSG00000144022 (from geneSymbol) uc338zas.1 uc338zas.1 
ENSMUST00000380762.1 2310043O21Rik ENSMUST00000380762.1 2310043O21Rik (from geneSymbol) AK009791 uc338zau.1 uc338zau.1 
ENSMUST00000380779.1 ENSMUSG00000144023 ENSMUST00000380779.1 ENSMUSG00000144023 (from geneSymbol) uc338zbl.1 uc338zbl.1 
ENSMUST00000380780.1 ENSMUSG00000144024 ENSMUST00000380780.1 ENSMUSG00000144024 (from geneSymbol) uc338zbm.1 uc338zbm.1 
ENSMUST00000380782.1 ENSMUSG00000144025 ENSMUST00000380782.1 ENSMUSG00000144025 (from geneSymbol) uc338zbo.1 uc338zbo.1 
ENSMUST00000380783.1 ENSMUSG00000144026 ENSMUST00000380783.1 ENSMUSG00000144026 (from geneSymbol) uc338zbp.1 uc338zbp.1 
ENSMUST00000380784.1 ENSMUSG00000144027 ENSMUST00000380784.1 ENSMUSG00000144027 (from geneSymbol) uc338zbq.1 uc338zbq.1 
ENSMUST00000380792.1 ENSMUSG00000144028 ENSMUST00000380792.1 ENSMUSG00000144028 (from geneSymbol) uc338zby.1 uc338zby.1 
ENSMUST00000380793.1 ENSMUSG00000144029 ENSMUST00000380793.1 ENSMUSG00000144029 (from geneSymbol) uc338zbz.1 uc338zbz.1 
ENSMUST00000380794.1 ENSMUSG00000144030 ENSMUST00000380794.1 ENSMUSG00000144030 (from geneSymbol) uc338zca.1 uc338zca.1 
ENSMUST00000380795.1 ENSMUSG00000144031 ENSMUST00000380795.1 ENSMUSG00000144031 (from geneSymbol) uc338zcb.1 uc338zcb.1 
ENSMUST00000380798.1 ENSMUSG00000144032 ENSMUST00000380798.1 ENSMUSG00000144032 (from geneSymbol) uc338zce.1 uc338zce.1 
ENSMUST00000380803.1 ENSMUSG00000144033 ENSMUST00000380803.1 ENSMUSG00000144033 (from geneSymbol) uc338zcj.1 uc338zcj.1 
ENSMUST00000380804.1 ENSMUSG00000144034 ENSMUST00000380804.1 ENSMUSG00000144034 (from geneSymbol) uc338zck.1 uc338zck.1 
ENSMUST00000380805.1 ENSMUSG00000144035 ENSMUST00000380805.1 ENSMUSG00000144035 (from geneSymbol) uc338zcl.1 uc338zcl.1 
ENSMUST00000380807.1 ENSMUSG00000144036 ENSMUST00000380807.1 ENSMUSG00000144036 (from geneSymbol) uc338zcn.1 uc338zcn.1 
ENSMUST00000380808.1 ENSMUSG00000144037 ENSMUST00000380808.1 ENSMUSG00000144037 (from geneSymbol) uc338zco.1 uc338zco.1 
ENSMUST00000380812.1 ENSMUSG00000144038 ENSMUST00000380812.1 ENSMUSG00000144038 (from geneSymbol) uc338zcs.1 uc338zcs.1 
ENSMUST00000380817.1 ENSMUSG00000144039 ENSMUST00000380817.1 ENSMUSG00000144039 (from geneSymbol) uc338zcx.1 uc338zcx.1 
ENSMUST00000380818.1 ENSMUSG00000144040 ENSMUST00000380818.1 ENSMUSG00000144040 (from geneSymbol) uc338zcy.1 uc338zcy.1 
ENSMUST00000380819.1 Gm43688 ENSMUST00000380819.1 Gm43688 (from geneSymbol) AK019798 uc338zcz.1 uc338zcz.1 
ENSMUST00000380822.1 ENSMUSG00000144041 ENSMUST00000380822.1 ENSMUSG00000144041 (from geneSymbol) uc338zdc.1 uc338zdc.1 
ENSMUST00000380841.1 ENSMUSG00000144042 ENSMUST00000380841.1 ENSMUSG00000144042 (from geneSymbol) uc338zdv.1 uc338zdv.1 
ENSMUST00000380843.1 ENSMUSG00000144043 ENSMUST00000380843.1 ENSMUSG00000144043 (from geneSymbol) uc338zdx.1 uc338zdx.1 
ENSMUST00000380844.1 ENSMUSG00000144044 ENSMUST00000380844.1 ENSMUSG00000144044 (from geneSymbol) uc338zdy.1 uc338zdy.1 
ENSMUST00000380845.1 ENSMUSG00000144045 ENSMUST00000380845.1 ENSMUSG00000144045 (from geneSymbol) uc338zdz.1 uc338zdz.1 
ENSMUST00000380846.1 ENSMUSG00000144046 ENSMUST00000380846.1 ENSMUSG00000144046 (from geneSymbol) uc338zea.1 uc338zea.1 
ENSMUST00000380847.1 ENSMUSG00000144047 ENSMUST00000380847.1 ENSMUSG00000144047 (from geneSymbol) uc338zeb.1 uc338zeb.1 
ENSMUST00000380848.1 ENSMUSG00000144048 ENSMUST00000380848.1 ENSMUSG00000144048 (from geneSymbol) uc338zec.1 uc338zec.1 
ENSMUST00000380849.1 ENSMUSG00000144049 ENSMUST00000380849.1 ENSMUSG00000144049 (from geneSymbol) uc338zed.1 uc338zed.1 
ENSMUST00000380851.1 4930583P06Rik ENSMUST00000380851.1 4930583P06Rik (from geneSymbol) AK016345 uc338zef.1 uc338zef.1 
ENSMUST00000380855.1 ENSMUSG00000144050 ENSMUST00000380855.1 ENSMUSG00000144050 (from geneSymbol) uc338zej.1 uc338zej.1 
ENSMUST00000380856.1 Gm34081 ENSMUST00000380856.1 Gm34081 (from geneSymbol) uc338zek.1 uc338zek.1 
ENSMUST00000380865.1 ENSMUSG00000144051 ENSMUST00000380865.1 ENSMUSG00000144051 (from geneSymbol) LF224107 uc338zet.1 uc338zet.1 
ENSMUST00000380866.1 ENSMUSG00000144052 ENSMUST00000380866.1 ENSMUSG00000144052 (from geneSymbol) uc338zeu.1 uc338zeu.1 
ENSMUST00000380869.1 ENSMUSG00000144053 ENSMUST00000380869.1 ENSMUSG00000144053 (from geneSymbol) uc338zex.1 uc338zex.1 
ENSMUST00000380870.1 Gm48057 ENSMUST00000380870.1 Gm48057 (from geneSymbol) uc338zey.1 uc338zey.1 
ENSMUST00000380872.1 ENSMUSG00000144054 ENSMUST00000380872.1 ENSMUSG00000144054 (from geneSymbol) uc338zfa.1 uc338zfa.1 
ENSMUST00000380876.1 1810008I18Rik ENSMUST00000380876.1 1810008I18Rik (from geneSymbol) AK007376 uc338zfe.1 uc338zfe.1 
ENSMUST00000380885.1 ENSMUSG00000144055 ENSMUST00000380885.1 ENSMUSG00000144055 (from geneSymbol) uc338zfn.1 uc338zfn.1 
ENSMUST00000380887.1 ENSMUSG00000144056 ENSMUST00000380887.1 ENSMUSG00000144056 (from geneSymbol) uc338zfp.1 uc338zfp.1 
ENSMUST00000380891.1 ENSMUSG00000144057 ENSMUST00000380891.1 ENSMUSG00000144057 (from geneSymbol) LF197447 uc338zft.1 uc338zft.1 
ENSMUST00000380893.1 ENSMUSG00000144058 ENSMUST00000380893.1 ENSMUSG00000144058 (from geneSymbol) uc338zfv.1 uc338zfv.1 
ENSMUST00000380898.1 ENSMUSG00000144059 ENSMUST00000380898.1 ENSMUSG00000144059 (from geneSymbol) uc338zga.1 uc338zga.1 
ENSMUST00000380899.1 ENSMUSG00000144060 ENSMUST00000380899.1 ENSMUSG00000144060 (from geneSymbol) uc338zgb.1 uc338zgb.1 
ENSMUST00000380901.1 ENSMUSG00000144061 ENSMUST00000380901.1 ENSMUSG00000144061 (from geneSymbol) uc338zgd.1 uc338zgd.1 
ENSMUST00000380918.1 ENSMUSG00000144064 ENSMUST00000380918.1 ENSMUSG00000144064 (from geneSymbol) uc338zgs.1 uc338zgs.1 
ENSMUST00000380919.1 ENSMUSG00000144065 ENSMUST00000380919.1 ENSMUSG00000144065 (from geneSymbol) uc338zgt.1 uc338zgt.1 
ENSMUST00000380920.1 Gm34793 ENSMUST00000380920.1 Gm34793 (from geneSymbol) uc338zgu.1 uc338zgu.1 
ENSMUST00000380941.1 ENSMUSG00000144066 ENSMUST00000380941.1 ENSMUSG00000144066 (from geneSymbol) uc338zhm.1 uc338zhm.1 
ENSMUST00000380959.1 ENSMUSG00000144067 ENSMUST00000380959.1 ENSMUSG00000144067 (from geneSymbol) uc338zie.1 uc338zie.1 
ENSMUST00000380960.1 Gm35326 ENSMUST00000380960.1 Gm35326 (from geneSymbol) uc338zif.1 uc338zif.1 
ENSMUST00000380966.1 ENSMUSG00000144068 ENSMUST00000380966.1 ENSMUSG00000144068 (from geneSymbol) uc338zil.1 uc338zil.1 
ENSMUST00000380972.1 ENSMUSG00000144069 ENSMUST00000380972.1 ENSMUSG00000144069 (from geneSymbol) uc338zir.1 uc338zir.1 
ENSMUST00000380975.1 ENSMUSG00000144070 ENSMUST00000380975.1 ENSMUSG00000144070 (from geneSymbol) uc338ziu.1 uc338ziu.1 
ENSMUST00000380976.1 Gm16013 ENSMUST00000380976.1 Gm16013 (from geneSymbol) uc338ziv.1 uc338ziv.1 
ENSMUST00000380978.1 ENSMUSG00000144071 ENSMUST00000380978.1 ENSMUSG00000144071 (from geneSymbol) uc338zix.1 uc338zix.1 
ENSMUST00000380983.1 Gm16312 ENSMUST00000380983.1 Gm16312 (from geneSymbol) uc338zjc.1 uc338zjc.1 
ENSMUST00000380990.1 ENSMUSG00000144072 ENSMUST00000380990.1 ENSMUSG00000144072 (from geneSymbol) uc338zjj.1 uc338zjj.1 
ENSMUST00000381017.1 ENSMUSG00000144073 ENSMUST00000381017.1 ENSMUSG00000144073 (from geneSymbol) uc338zkk.1 uc338zkk.1 
ENSMUST00000381021.1 Cirpil ENSMUST00000381021.1 Cirpil (from geneSymbol) uc338zko.1 uc338zko.1 
ENSMUST00000381026.1 ENSMUSG00000144074 ENSMUST00000381026.1 ENSMUSG00000144074 (from geneSymbol) uc338zkt.1 uc338zkt.1 
ENSMUST00000381029.1 ENSMUSG00000144075 ENSMUST00000381029.1 ENSMUSG00000144075 (from geneSymbol) uc338zkw.1 uc338zkw.1 
ENSMUST00000381030.1 ENSMUSG00000144076 ENSMUST00000381030.1 ENSMUSG00000144076 (from geneSymbol) uc338zkx.1 uc338zkx.1 
ENSMUST00000381031.1 ENSMUSG00000144077 ENSMUST00000381031.1 ENSMUSG00000144077 (from geneSymbol) uc338zky.1 uc338zky.1 
ENSMUST00000381033.1 ENSMUSG00000144078 ENSMUST00000381033.1 ENSMUSG00000144078 (from geneSymbol) AK156776 uc338zla.1 uc338zla.1 
ENSMUST00000381034.1 ENSMUSG00000144079 ENSMUST00000381034.1 ENSMUSG00000144079 (from geneSymbol) uc338zlb.1 uc338zlb.1 
ENSMUST00000381037.1 ENSMUSG00000144080 ENSMUST00000381037.1 ENSMUSG00000144080 (from geneSymbol) uc338zle.1 uc338zle.1 
ENSMUST00000381047.1 ENSMUSG00000144081 ENSMUST00000381047.1 ENSMUSG00000144081 (from geneSymbol) uc338zlo.1 uc338zlo.1 
ENSMUST00000381051.1 ENSMUSG00000144082 ENSMUST00000381051.1 ENSMUSG00000144082 (from geneSymbol) uc338zls.1 uc338zls.1 
ENSMUST00000381056.1 ENSMUSG00000144083 ENSMUST00000381056.1 ENSMUSG00000144083 (from geneSymbol) uc338zlx.1 uc338zlx.1 
ENSMUST00000381061.1 ENSMUSG00000144084 ENSMUST00000381061.1 ENSMUSG00000144084 (from geneSymbol) uc338zmc.1 uc338zmc.1 
ENSMUST00000381072.1 ENSMUSG00000144085 ENSMUST00000381072.1 ENSMUSG00000144085 (from geneSymbol) uc338zmn.1 uc338zmn.1 
ENSMUST00000381076.1 ENSMUSG00000144086 ENSMUST00000381076.1 ENSMUSG00000144086 (from geneSymbol) uc338zmr.1 uc338zmr.1 
ENSMUST00000381080.1 ENSMUSG00000144087 ENSMUST00000381080.1 ENSMUSG00000144087 (from geneSymbol) uc338zmv.1 uc338zmv.1 
ENSMUST00000381082.1 ENSMUSG00000144088 ENSMUST00000381082.1 ENSMUSG00000144088 (from geneSymbol) uc338zmx.1 uc338zmx.1 
ENSMUST00000381086.1 ENSMUSG00000144089 ENSMUST00000381086.1 ENSMUSG00000144089 (from geneSymbol) uc338znb.1 uc338znb.1 
ENSMUST00000381087.1 ENSMUSG00000144090 ENSMUST00000381087.1 ENSMUSG00000144090 (from geneSymbol) uc338znc.1 uc338znc.1 
ENSMUST00000381089.1 ENSMUSG00000144091 ENSMUST00000381089.1 ENSMUSG00000144091 (from geneSymbol) uc338zne.1 uc338zne.1 
ENSMUST00000381090.1 ENSMUSG00000144092 ENSMUST00000381090.1 ENSMUSG00000144092 (from geneSymbol) LF197562 uc338znf.1 uc338znf.1 
ENSMUST00000381091.1 ENSMUSG00000144093 ENSMUST00000381091.1 ENSMUSG00000144093 (from geneSymbol) uc338zng.1 uc338zng.1 
ENSMUST00000381092.1 ENSMUSG00000144094 ENSMUST00000381092.1 ENSMUSG00000144094 (from geneSymbol) uc338znh.1 uc338znh.1 
ENSMUST00000381093.1 ENSMUSG00000144095 ENSMUST00000381093.1 ENSMUSG00000144095 (from geneSymbol) uc338zni.1 uc338zni.1 
ENSMUST00000381106.1 ENSMUSG00000144096 ENSMUST00000381106.1 ENSMUSG00000144096 (from geneSymbol) uc338znt.1 uc338znt.1 
ENSMUST00000381107.1 4930537H20Rik ENSMUST00000381107.1 4930537H20Rik (from geneSymbol) uc338znu.1 uc338znu.1 
ENSMUST00000381108.1 ENSMUSG00000144097 ENSMUST00000381108.1 ENSMUSG00000144097 (from geneSymbol) uc338znv.1 uc338znv.1 
ENSMUST00000381118.1 Gm16277 ENSMUST00000381118.1 Gm16277 (from geneSymbol) uc338zof.1 uc338zof.1 
ENSMUST00000381132.1 Gm31946 ENSMUST00000381132.1 Gm31946 (from geneSymbol) uc338zot.1 uc338zot.1 
ENSMUST00000381145.1 ENSMUSG00000144098 ENSMUST00000381145.1 ENSMUSG00000144098 (from geneSymbol) uc338zpg.1 uc338zpg.1 
ENSMUST00000381149.1 ENSMUSG00000144099 ENSMUST00000381149.1 ENSMUSG00000144099 (from geneSymbol) uc338zpk.1 uc338zpk.1 
ENSMUST00000381150.1 ENSMUSG00000144100 ENSMUST00000381150.1 ENSMUSG00000144100 (from geneSymbol) uc338zpl.1 uc338zpl.1 
ENSMUST00000381152.1 ENSMUSG00000144101 ENSMUST00000381152.1 ENSMUSG00000144101 (from geneSymbol) uc338zpn.1 uc338zpn.1 
ENSMUST00000381157.1 ENSMUSG00000144102 ENSMUST00000381157.1 ENSMUSG00000144102 (from geneSymbol) uc338zps.1 uc338zps.1 
ENSMUST00000381162.1 ENSMUSG00000144103 ENSMUST00000381162.1 ENSMUSG00000144103 (from geneSymbol) uc338zpx.1 uc338zpx.1 
ENSMUST00000381163.1 ENSMUSG00000144104 ENSMUST00000381163.1 ENSMUSG00000144104 (from geneSymbol) uc338zpy.1 uc338zpy.1 
ENSMUST00000381164.1 ENSMUSG00000144105 ENSMUST00000381164.1 ENSMUSG00000144105 (from geneSymbol) uc338zpz.1 uc338zpz.1 
ENSMUST00000381166.1 ENSMUSG00000144106 ENSMUST00000381166.1 ENSMUSG00000144106 (from geneSymbol) uc338zqb.1 uc338zqb.1 
ENSMUST00000381173.1 ENSMUSG00000144107 ENSMUST00000381173.1 ENSMUSG00000144107 (from geneSymbol) uc338zqi.1 uc338zqi.1 
ENSMUST00000381175.1 ENSMUSG00000144108 ENSMUST00000381175.1 ENSMUSG00000144108 (from geneSymbol) uc338zqk.1 uc338zqk.1 
ENSMUST00000381176.1 ENSMUSG00000144109 ENSMUST00000381176.1 ENSMUSG00000144109 (from geneSymbol) uc338zql.1 uc338zql.1 
ENSMUST00000381177.1 Gm47667 ENSMUST00000381177.1 Gm47667 (from geneSymbol) uc338zqm.1 uc338zqm.1 
ENSMUST00000381183.1 ENSMUSG00000144110 ENSMUST00000381183.1 ENSMUSG00000144110 (from geneSymbol) uc338zqs.1 uc338zqs.1 
ENSMUST00000381184.1 ENSMUSG00000144111 ENSMUST00000381184.1 ENSMUSG00000144111 (from geneSymbol) uc338zqt.1 uc338zqt.1 
ENSMUST00000381186.1 ENSMUSG00000144112 ENSMUST00000381186.1 ENSMUSG00000144112 (from geneSymbol) uc338zqv.1 uc338zqv.1 
ENSMUST00000381188.1 ENSMUSG00000144113 ENSMUST00000381188.1 ENSMUSG00000144113 (from geneSymbol) uc338zqx.1 uc338zqx.1 
ENSMUST00000381190.1 Gm13373 ENSMUST00000381190.1 Gm13373 (from geneSymbol) KY467843 uc338zqz.1 uc338zqz.1 
ENSMUST00000381265.1 ENSMUSG00000144114 ENSMUST00000381265.1 ENSMUSG00000144114 (from geneSymbol) uc338ztw.1 uc338ztw.1 
ENSMUST00000381272.1 1700029N11Rik ENSMUST00000381272.1 1700029N11Rik (from geneSymbol) AK006512 uc338zud.1 uc338zud.1 
ENSMUST00000381302.1 ENSMUSG00000144115 ENSMUST00000381302.1 ENSMUSG00000144115 (from geneSymbol) uc338zvh.1 uc338zvh.1 
ENSMUST00000381304.1 Gm11479 ENSMUST00000381304.1 Gm11479 (from geneSymbol) AK076774 uc338zvj.1 uc338zvj.1 
ENSMUST00000381306.1 Gm14145 ENSMUST00000381306.1 Gm14145 (from geneSymbol) uc338zvl.1 uc338zvl.1 
ENSMUST00000381308.1 ENSMUSG00000144116 ENSMUST00000381308.1 ENSMUSG00000144116 (from geneSymbol) uc338zvn.1 uc338zvn.1 
ENSMUST00000381321.1 ENSMUSG00000144117 ENSMUST00000381321.1 ENSMUSG00000144117 (from geneSymbol) uc338zwa.1 uc338zwa.1 
ENSMUST00000381325.1 ENSMUSG00000144118 ENSMUST00000381325.1 ENSMUSG00000144118 (from geneSymbol) uc338zwe.1 uc338zwe.1 
ENSMUST00000381326.1 ENSMUSG00000144119 ENSMUST00000381326.1 ENSMUSG00000144119 (from geneSymbol) uc338zwf.1 uc338zwf.1 
ENSMUST00000381330.1 Gm11981 ENSMUST00000381330.1 Gm11981 (from geneSymbol) AK076664 uc338zwj.1 uc338zwj.1 
ENSMUST00000381336.1 ENSMUSG00000144120 ENSMUST00000381336.1 ENSMUSG00000144120 (from geneSymbol) uc338zwp.1 uc338zwp.1 
ENSMUST00000381343.1 ENSMUSG00000144121 ENSMUST00000381343.1 ENSMUSG00000144121 (from geneSymbol) uc338zww.1 uc338zww.1 
ENSMUST00000381344.1 ENSMUSG00000144122 ENSMUST00000381344.1 ENSMUSG00000144122 (from geneSymbol) uc338zwx.1 uc338zwx.1 
ENSMUST00000381348.1 ENSMUSG00000144123 ENSMUST00000381348.1 ENSMUSG00000144123 (from geneSymbol) uc338zxb.1 uc338zxb.1 
ENSMUST00000381350.1 ENSMUSG00000144124 ENSMUST00000381350.1 ENSMUSG00000144124 (from geneSymbol) uc338zxd.1 uc338zxd.1 
ENSMUST00000381351.1 ENSMUSG00000144125 ENSMUST00000381351.1 ENSMUSG00000144125 (from geneSymbol) uc338zxe.1 uc338zxe.1 
ENSMUST00000381352.1 ENSMUSG00000144126 ENSMUST00000381352.1 ENSMUSG00000144126 (from geneSymbol) uc338zxf.1 uc338zxf.1 
ENSMUST00000381354.1 ENSMUSG00000144127 ENSMUST00000381354.1 ENSMUSG00000144127 (from geneSymbol) uc338zxh.1 uc338zxh.1 
ENSMUST00000381357.1 ENSMUSG00000144128 ENSMUST00000381357.1 ENSMUSG00000144128 (from geneSymbol) uc338zxk.1 uc338zxk.1 
ENSMUST00000381362.1 ENSMUSG00000144129 ENSMUST00000381362.1 ENSMUSG00000144129 (from geneSymbol) uc338zxp.1 uc338zxp.1 
ENSMUST00000381363.1 ENSMUSG00000144130 ENSMUST00000381363.1 ENSMUSG00000144130 (from geneSymbol) uc338zxq.1 uc338zxq.1 
ENSMUST00000381365.1 ENSMUSG00000144131 ENSMUST00000381365.1 ENSMUSG00000144131 (from geneSymbol) uc338zxs.1 uc338zxs.1 
ENSMUST00000381369.1 ENSMUSG00000121804 ENSMUST00000381369.1 ENSMUSG00000121804 (from geneSymbol) uc338zxw.1 uc338zxw.1 
ENSMUST00000381380.1 ENSMUSG00000144132 ENSMUST00000381380.1 ENSMUSG00000144132 (from geneSymbol) uc338zyh.1 uc338zyh.1 
ENSMUST00000381381.1 Gm14207 ENSMUST00000381381.1 Gm14207 (from geneSymbol) KP171172 uc338zyi.1 uc338zyi.1 
ENSMUST00000381397.1 1700016P03Rik ENSMUST00000381397.1 1700016P03Rik (from geneSymbol) AK006051 uc338zyy.1 uc338zyy.1 
ENSMUST00000381402.1 ENSMUSG00000144133 ENSMUST00000381402.1 ENSMUSG00000144133 (from geneSymbol) uc338zzd.1 uc338zzd.1 
ENSMUST00000381404.1 ENSMUSG00000144134 ENSMUST00000381404.1 ENSMUSG00000144134 (from geneSymbol) uc338zzf.1 uc338zzf.1 
ENSMUST00000381408.1 Gm30173 ENSMUST00000381408.1 Gm30173 (from geneSymbol) AK040671 uc338zzj.1 uc338zzj.1 
ENSMUST00000381421.1 ENSMUSG00000144135 ENSMUST00000381421.1 ENSMUSG00000144135 (from geneSymbol) uc338zzw.1 uc338zzw.1 
ENSMUST00000381424.1 ENSMUSG00000144136 ENSMUST00000381424.1 ENSMUSG00000144136 (from geneSymbol) uc338zzz.1 uc338zzz.1 
ENSMUST00000381425.1 ENSMUSG00000144137 ENSMUST00000381425.1 ENSMUSG00000144137 (from geneSymbol) uc339aaa.1 uc339aaa.1 
ENSMUST00000381427.1 ENSMUSG00000144138 ENSMUST00000381427.1 ENSMUSG00000144138 (from geneSymbol) uc339aac.1 uc339aac.1 
ENSMUST00000381430.1 ENSMUSG00000144139 ENSMUST00000381430.1 ENSMUSG00000144139 (from geneSymbol) uc339aaf.1 uc339aaf.1 
ENSMUST00000381431.1 1700023F02Rik ENSMUST00000381431.1 1700023F02Rik (from geneSymbol) AK006272 uc339aag.1 uc339aag.1 
ENSMUST00000381481.1 ENSMUSG00000144140 ENSMUST00000381481.1 ENSMUSG00000144140 (from geneSymbol) uc339acd.1 uc339acd.1 
ENSMUST00000381482.1 ENSMUSG00000144141 ENSMUST00000381482.1 ENSMUSG00000144141 (from geneSymbol) uc339ace.1 uc339ace.1 
ENSMUST00000381485.1 ENSMUSG00000144142 ENSMUST00000381485.1 ENSMUSG00000144142 (from geneSymbol) uc339ach.1 uc339ach.1 
ENSMUST00000381489.1 Gm30034 ENSMUST00000381489.1 Gm30034 (from geneSymbol) KY467534 uc339acl.1 uc339acl.1 
ENSMUST00000381497.1 Gm17224 ENSMUST00000381497.1 Gm17224 (from geneSymbol) uc339act.1 uc339act.1 
ENSMUST00000381500.1 ENSMUSG00000144143 ENSMUST00000381500.1 ENSMUSG00000144143 (from geneSymbol) uc339acw.1 uc339acw.1 
ENSMUST00000381502.1 ENSMUSG00000144144 ENSMUST00000381502.1 ENSMUSG00000144144 (from geneSymbol) uc339acy.1 uc339acy.1 
ENSMUST00000381503.1 ENSMUSG00000144145 ENSMUST00000381503.1 ENSMUSG00000144145 (from geneSymbol) uc339acz.1 uc339acz.1 
ENSMUST00000381514.1 ENSMUSG00000144146 ENSMUST00000381514.1 ENSMUSG00000144146 (from geneSymbol) uc339adf.1 uc339adf.1 
ENSMUST00000381529.1 ENSMUSG00000144147 ENSMUST00000381529.1 ENSMUSG00000144147 (from geneSymbol) uc339adu.1 uc339adu.1 
ENSMUST00000381534.1 Gm15417 ENSMUST00000381534.1 Gm15417 (from geneSymbol) AK161599 uc339ady.1 uc339ady.1 
ENSMUST00000381590.1 ENSMUSG00000144148 ENSMUST00000381590.1 ENSMUSG00000144148 (from geneSymbol) uc339agc.1 uc339agc.1 
ENSMUST00000381592.1 ENSMUSG00000144149 ENSMUST00000381592.1 ENSMUSG00000144149 (from geneSymbol) uc339age.1 uc339age.1 
ENSMUST00000381594.1 ENSMUSG00000144150 ENSMUST00000381594.1 ENSMUSG00000144150 (from geneSymbol) uc339agg.1 uc339agg.1 
ENSMUST00000381596.1 ENSMUSG00000144151 ENSMUST00000381596.1 ENSMUSG00000144151 (from geneSymbol) uc339agi.1 uc339agi.1 
ENSMUST00000381602.1 ENSMUSG00000144152 ENSMUST00000381602.1 ENSMUSG00000144152 (from geneSymbol) uc339ago.1 uc339ago.1 
ENSMUST00000381606.1 ENSMUSG00000144153 ENSMUST00000381606.1 ENSMUSG00000144153 (from geneSymbol) uc339ags.1 uc339ags.1 
ENSMUST00000381607.1 ENSMUSG00000144154 ENSMUST00000381607.1 ENSMUSG00000144154 (from geneSymbol) AK045151 uc339agt.1 uc339agt.1 
ENSMUST00000381609.1 ENSMUSG00000144155 ENSMUST00000381609.1 ENSMUSG00000144155 (from geneSymbol) uc339agv.1 uc339agv.1 
ENSMUST00000381611.1 ENSMUSG00000144156 ENSMUST00000381611.1 ENSMUSG00000144156 (from geneSymbol) uc339agx.1 uc339agx.1 
ENSMUST00000381614.1 ENSMUSG00000144157 ENSMUST00000381614.1 ENSMUSG00000144157 (from geneSymbol) uc339aha.1 uc339aha.1 
ENSMUST00000381615.1 ENSMUSG00000144158 ENSMUST00000381615.1 ENSMUSG00000144158 (from geneSymbol) uc339ahb.1 uc339ahb.1 
ENSMUST00000381618.1 ENSMUSG00000144159 ENSMUST00000381618.1 ENSMUSG00000144159 (from geneSymbol) uc339ahe.1 uc339ahe.1 
ENSMUST00000381620.1 ENSMUSG00000144160 ENSMUST00000381620.1 ENSMUSG00000144160 (from geneSymbol) uc339ahg.1 uc339ahg.1 
ENSMUST00000381623.1 4930563M21Rik ENSMUST00000381623.1 4930563M21Rik (from geneSymbol) AK016210 uc339ahj.1 uc339ahj.1 
ENSMUST00000381627.1 ENSMUSG00000144161 ENSMUST00000381627.1 ENSMUSG00000144161 (from geneSymbol) uc339ahn.1 uc339ahn.1 
ENSMUST00000381628.1 4930407I19Rik ENSMUST00000381628.1 4930407I19Rik (from geneSymbol) AK019573 uc339aho.1 uc339aho.1 
ENSMUST00000381637.1 ENSMUSG00000144163 ENSMUST00000381637.1 ENSMUSG00000144163 (from geneSymbol) uc339ahv.1 uc339ahv.1 
ENSMUST00000381644.1 ENSMUSG00000144164 ENSMUST00000381644.1 ENSMUSG00000144164 (from geneSymbol) uc339aic.1 uc339aic.1 
ENSMUST00000381645.1 ENSMUSG00000144165 ENSMUST00000381645.1 ENSMUSG00000144165 (from geneSymbol) uc339aid.1 uc339aid.1 
ENSMUST00000381646.1 ENSMUSG00000144166 ENSMUST00000381646.1 ENSMUSG00000144166 (from geneSymbol) uc339aie.1 uc339aie.1 
ENSMUST00000381647.1 ENSMUSG00000144167 ENSMUST00000381647.1 ENSMUSG00000144167 (from geneSymbol) uc339aif.1 uc339aif.1 
ENSMUST00000381654.1 ENSMUSG00000144168 ENSMUST00000381654.1 ENSMUSG00000144168 (from geneSymbol) uc339aim.1 uc339aim.1 
ENSMUST00000381656.1 ENSMUSG00000144169 ENSMUST00000381656.1 ENSMUSG00000144169 (from geneSymbol) uc339aio.1 uc339aio.1 
ENSMUST00000381657.1 ENSMUSG00000144170 ENSMUST00000381657.1 ENSMUSG00000144170 (from geneSymbol) uc339aip.1 uc339aip.1 
ENSMUST00000381662.1 ENSMUSG00000144171 ENSMUST00000381662.1 ENSMUSG00000144171 (from geneSymbol) uc339aiu.1 uc339aiu.1 
ENSMUST00000381663.1 ENSMUSG00000144172 ENSMUST00000381663.1 ENSMUSG00000144172 (from geneSymbol) uc339aiv.1 uc339aiv.1 
ENSMUST00000381664.1 ENSMUSG00000144173 ENSMUST00000381664.1 ENSMUSG00000144173 (from geneSymbol) uc339aiw.1 uc339aiw.1 
ENSMUST00000381665.1 ENSMUSG00000144174 ENSMUST00000381665.1 ENSMUSG00000144174 (from geneSymbol) uc339aix.1 uc339aix.1 
ENSMUST00000381666.1 ENSMUSG00000144175 ENSMUST00000381666.1 ENSMUSG00000144175 (from geneSymbol) uc339aiy.1 uc339aiy.1 
ENSMUST00000381667.1 ENSMUSG00000144176 ENSMUST00000381667.1 ENSMUSG00000144176 (from geneSymbol) uc339aiz.1 uc339aiz.1 
ENSMUST00000381668.1 ENSMUSG00000144177 ENSMUST00000381668.1 ENSMUSG00000144177 (from geneSymbol) uc339aja.1 uc339aja.1 
ENSMUST00000381669.1 ENSMUSG00000144178 ENSMUST00000381669.1 ENSMUSG00000144178 (from geneSymbol) uc339ajb.1 uc339ajb.1 
ENSMUST00000381670.1 ENSMUSG00000144179 ENSMUST00000381670.1 ENSMUSG00000144179 (from geneSymbol) uc339ajc.1 uc339ajc.1 
ENSMUST00000381672.1 ENSMUSG00000144180 ENSMUST00000381672.1 ENSMUSG00000144180 (from geneSymbol) uc339aje.1 uc339aje.1 
ENSMUST00000381677.1 Gm47805 ENSMUST00000381677.1 Gm47805 (from geneSymbol) uc339ajj.1 uc339ajj.1 
ENSMUST00000381678.1 ENSMUSG00000144181 ENSMUST00000381678.1 ENSMUSG00000144181 (from geneSymbol) uc339ajk.1 uc339ajk.1 
ENSMUST00000381679.1 ENSMUSG00000144182 ENSMUST00000381679.1 ENSMUSG00000144182 (from geneSymbol) uc339ajl.1 uc339ajl.1 
ENSMUST00000381680.1 ENSMUSG00000144183 ENSMUST00000381680.1 ENSMUSG00000144183 (from geneSymbol) uc339ajm.1 uc339ajm.1 
ENSMUST00000381682.1 ENSMUSG00000144185 ENSMUST00000381682.1 ENSMUSG00000144185 (from geneSymbol) uc339ajn.1 uc339ajn.1 
ENSMUST00000381684.1 Gm15998 ENSMUST00000381684.1 Gm15998 (from geneSymbol) AK140090 uc339ajp.1 uc339ajp.1 
ENSMUST00000381685.1 ENSMUSG00000144186 ENSMUST00000381685.1 ENSMUSG00000144186 (from geneSymbol) uc339ajq.1 uc339ajq.1 
ENSMUST00000381688.1 ENSMUSG00000144187 ENSMUST00000381688.1 ENSMUSG00000144187 (from geneSymbol) uc339ajt.1 uc339ajt.1 
ENSMUST00000381689.1 ENSMUSG00000144188 ENSMUST00000381689.1 ENSMUSG00000144188 (from geneSymbol) uc339aju.1 uc339aju.1 
ENSMUST00000381691.1 ENSMUSG00000144189 ENSMUST00000381691.1 ENSMUSG00000144189 (from geneSymbol) uc339ajw.1 uc339ajw.1 
ENSMUST00000381692.1 ENSMUSG00000144190 ENSMUST00000381692.1 ENSMUSG00000144190 (from geneSymbol) uc339ajx.1 uc339ajx.1 
ENSMUST00000381694.1 ENSMUSG00000144191 ENSMUST00000381694.1 ENSMUSG00000144191 (from geneSymbol) uc339ajz.1 uc339ajz.1 
ENSMUST00000381695.1 ENSMUSG00000144192 ENSMUST00000381695.1 ENSMUSG00000144192 (from geneSymbol) uc339aka.1 uc339aka.1 
ENSMUST00000381696.1 ENSMUSG00000144193 ENSMUST00000381696.1 ENSMUSG00000144193 (from geneSymbol) uc339akb.1 uc339akb.1 
ENSMUST00000381699.1 ENSMUSG00000144196 ENSMUST00000381699.1 ENSMUSG00000144196 (from geneSymbol) uc339ake.1 uc339ake.1 
ENSMUST00000381715.1 ENSMUSG00000144199 ENSMUST00000381715.1 ENSMUSG00000144199 (from geneSymbol) uc339akj.1 uc339akj.1 
ENSMUST00000381725.1 ENSMUSG00000144201 ENSMUST00000381725.1 ENSMUSG00000144201 (from geneSymbol) AK005333 uc339akm.1 uc339akm.1 
ENSMUST00000381729.1 ENSMUSG00000144203 ENSMUST00000381729.1 ENSMUSG00000144203 (from geneSymbol) BC108341 uc339akn.1 uc339akn.1 
ENSMUST00000381735.1 ENSMUSG00000144204 ENSMUST00000381735.1 ENSMUSG00000144204 (from geneSymbol) AK139759 uc339ako.1 uc339ako.1 
ENSMUST00000381752.1 Gm56662 ENSMUST00000381752.1 Gm56662 (from geneSymbol) uc339akv.1 uc339akv.1 
ENSMUST00001239500.1 Gm23947 ENSMUST00001239500.1 Gm23947 (from geneSymbol) uc288vzq.1 uc288vzq.1 
ENSMUST00001239502.1 Mir467a-6 ENSMUST00001239502.1 microRNA 467a-6 (from RefSeq NR_037258.1) NR_037258 uc288vzr.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vzr.1 
ENSMUST00001239503.1 Gm25934 ENSMUST00001239503.1 Gm25934 (from geneSymbol) uc288vzs.1 uc288vzs.1 
ENSMUST00001239504.1 Gm23076 ENSMUST00001239504.1 Gm23076 (from geneSymbol) uc288vzt.1 uc288vzt.1 
ENSMUST00001239505.1 Gm22645 ENSMUST00001239505.1 Gm22645 (from geneSymbol) DQ558729 uc288vzu.1 uc288vzu.1 
ENSMUST00001239506.1 Gm25538 ENSMUST00001239506.1 Gm25538 (from geneSymbol) uc288vzv.1 uc288vzv.1 
ENSMUST00001239507.1 Gm25679 ENSMUST00001239507.1 Gm25679 (from geneSymbol) FM991912 uc288vzw.1 uc288vzw.1 
ENSMUST00001239508.1 n-R5s129 ENSMUST00001239508.1 n-R5s129 (from geneSymbol) uc288vzx.1 uc288vzx.1 
ENSMUST00001239510.1 Mir6546 ENSMUST00001239510.1 microRNA 6546 (from RefSeq NR_106103.1) NR_106103 uc288vzy.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288vzy.1 
ENSMUST00001239512.1 Gm23298 ENSMUST00001239512.1 Gm23298 (from geneSymbol) DQ558729 uc288vzz.1 uc288vzz.1 
ENSMUST00001239515.1 Gm26295 ENSMUST00001239515.1 Gm26295 (from geneSymbol) DQ558729 uc288waa.1 uc288waa.1 
ENSMUST00001239516.1 Gm23686 ENSMUST00001239516.1 Gm23686 (from geneSymbol) DQ548138 uc288wab.1 uc288wab.1 
ENSMUST00001239518.1 Gm24497 ENSMUST00001239518.1 Gm24497 (from geneSymbol) DQ551040 uc288wac.1 uc288wac.1 
ENSMUST00001239519.1 Gm26180 ENSMUST00001239519.1 Gm26180 (from geneSymbol) uc288wad.1 uc288wad.1 
ENSMUST00001239520.1 Gm24097 ENSMUST00001239520.1 Gm24097 (from geneSymbol) uc288wae.1 uc288wae.1 
ENSMUST00001239521.1 Gm22374 ENSMUST00001239521.1 Gm22374 (from geneSymbol) uc288waf.1 uc288waf.1 
ENSMUST00001239525.1 Gm25935 ENSMUST00001239525.1 Gm25935 (from geneSymbol) DQ558729 uc288wag.1 uc288wag.1 
ENSMUST00001239528.1 Gm22450 ENSMUST00001239528.1 Gm22450 (from geneSymbol) DQ558729 uc288wah.1 uc288wah.1 
ENSMUST00001239531.1 Rnu1b1 ENSMUST00001239531.1 U1b1 small nuclear RNA (from RefSeq NR_004412.1) NR_004412 uc288wai.1 uc288wai.1 
ENSMUST00001239532.1 Gm25629 ENSMUST00001239532.1 Gm25629 (from geneSymbol) uc288waj.1 uc288waj.1 
ENSMUST00001239534.1 Gm23932 ENSMUST00001239534.1 Gm23932 (from geneSymbol) uc288wak.1 uc288wak.1 
ENSMUST00001239536.1 Gm23767 ENSMUST00001239536.1 Gm23767 (from geneSymbol) uc288wal.1 uc288wal.1 
ENSMUST00001239537.1 Gm23448 ENSMUST00001239537.1 Gm23448 (from geneSymbol) uc288wam.1 uc288wam.1 
ENSMUST00001239540.1 Gm23217 ENSMUST00001239540.1 Gm23217 (from geneSymbol) DQ558729 uc288wan.1 uc288wan.1 
ENSMUST00001239542.1 Gm22614 ENSMUST00001239542.1 Gm22614 (from geneSymbol) AB349931 uc288wao.1 uc288wao.1 
ENSMUST00001239545.1 Gm22006 ENSMUST00001239545.1 Gm22006 (from geneSymbol) uc288wap.1 uc288wap.1 
ENSMUST00001239547.1 Gm22131 ENSMUST00001239547.1 Gm22131 (from geneSymbol) uc288waq.1 uc288waq.1 
ENSMUST00001239548.1 Gm25194 ENSMUST00001239548.1 Gm25194 (from geneSymbol) uc288war.1 uc288war.1 
ENSMUST00001239549.1 Gm23864 ENSMUST00001239549.1 Gm23864 (from geneSymbol) LF201063 uc288was.1 uc288was.1 
ENSMUST00001239551.1 Gm25617 ENSMUST00001239551.1 Gm25617 (from geneSymbol) AF357391 uc288wat.1 uc288wat.1 
ENSMUST00001239553.1 Gm24088 ENSMUST00001239553.1 Gm24088 (from geneSymbol) uc288wau.1 uc288wau.1 
ENSMUST00001239554.1 Gm23953 ENSMUST00001239554.1 Gm23953 (from geneSymbol) uc288wav.1 uc288wav.1 
ENSMUST00001239555.1 n-R5s103 ENSMUST00001239555.1 nuclear encoded rRNA 5S 103 (from RefSeq NR_046119.1) NR_046119 uc288waw.1 uc288waw.1 
ENSMUST00001239556.1 Gm22421 ENSMUST00001239556.1 Gm22421 (from geneSymbol) uc288wax.1 uc288wax.1 
ENSMUST00001239557.1 Gm24952 ENSMUST00001239557.1 Gm24952 (from geneSymbol) uc288way.1 uc288way.1 
ENSMUST00001239558.1 Gm26390 ENSMUST00001239558.1 Gm26390 (from geneSymbol) uc288waz.1 uc288waz.1 
ENSMUST00001239559.1 Gm26283 ENSMUST00001239559.1 Gm26283 (from geneSymbol) uc288wba.1 uc288wba.1 
ENSMUST00001239560.1 Gm23678 ENSMUST00001239560.1 Gm23678 (from geneSymbol) DQ558729 uc288wbb.1 uc288wbb.1 
ENSMUST00001239561.1 Gm24390 ENSMUST00001239561.1 Gm24390 (from geneSymbol) uc288wbc.1 uc288wbc.1 
ENSMUST00001239562.1 Gm26245 ENSMUST00001239562.1 Gm26245 (from geneSymbol) DQ558729 uc288wbd.1 uc288wbd.1 
ENSMUST00001239564.1 n-R5s113 ENSMUST00001239564.1 nuclear encoded rRNA 5S 113 (from RefSeq NR_046126.1) NR_046126 uc288wbe.1 uc288wbe.1 
ENSMUST00001239565.1 Gm25740 ENSMUST00001239565.1 Gm25740 (from geneSymbol) uc288wbf.1 uc288wbf.1 
ENSMUST00010126032.3 Iqcf3 ENSMUST00010126032.3 IQ motif containing F3, transcript variant 2 (from RefSeq NM_026645.3) ENSMUST00010126032.1 ENSMUST00010126032.2 IQCF3_MOUSE NM_026645 Q9D498 uc288wbg.1 calmodulin binding uc288wbg.1 
ENSMUST00020181660.1 Vaultrc5 ENSMUST00020181660.1 Vaultrc5 (from geneSymbol) uc288wbm.1 uc288wbm.1 
ENSMUST00020181661.1 Vaultrc-ps1 ENSMUST00020181661.1 Vaultrc-ps1 (from geneSymbol) uc288wbn.1 uc288wbn.1 
ENSMUST00020181662.1 Gm54743 ENSMUST00020181662.1 Gm54743 (from geneSymbol) DQ311494 uc288wbo.1 uc288wbo.1 
ENSMUST00020181663.1 Gm55305 ENSMUST00020181663.1 Gm55305 (from geneSymbol) uc288wbp.1 uc288wbp.1 
ENSMUST00020181664.1 Gm55970 ENSMUST00020181664.1 Gm55970 (from geneSymbol) LF194501 uc288wbq.1 uc288wbq.1 
ENSMUST00020181665.1 Gm54935 ENSMUST00020181665.1 Gm54935 (from geneSymbol) uc288wbr.1 uc288wbr.1 
ENSMUST00020181666.1 Gm55165 ENSMUST00020181666.1 Gm55165 (from geneSymbol) uc288wbs.1 uc288wbs.1 
ENSMUST00020181667.1 Gm56231 ENSMUST00020181667.1 Gm56231 (from geneSymbol) uc288wbt.1 uc288wbt.1 
ENSMUST00020181668.1 Gm55300 ENSMUST00020181668.1 Gm55300 (from geneSymbol) uc288wbu.1 uc288wbu.1 
ENSMUST00020181669.1 Gm54383 ENSMUST00020181669.1 Gm54383 (from geneSymbol) uc288wbv.1 uc288wbv.1 
ENSMUST00020181670.1 Gm55209 ENSMUST00020181670.1 Gm55209 (from geneSymbol) DQ706860 uc288wbw.1 uc288wbw.1 
ENSMUST00020181671.1 Gm54392 ENSMUST00020181671.1 Gm54392 (from geneSymbol) uc288wbx.1 uc288wbx.1 
ENSMUST00020181672.1 Gm54405 ENSMUST00020181672.1 Gm54405 (from geneSymbol) uc288wby.1 uc288wby.1 
ENSMUST00020181673.1 Gm55345 ENSMUST00020181673.1 Gm55345 (from geneSymbol) uc288wbz.1 uc288wbz.1 
ENSMUST00020181674.1 Gm55941 ENSMUST00020181674.1 Gm55941 (from geneSymbol) uc288wca.1 uc288wca.1 
ENSMUST00020181675.1 Gm55742 ENSMUST00020181675.1 Gm55742 (from geneSymbol) FR668225 uc288wcb.1 uc288wcb.1 
ENSMUST00020181676.1 Gm55952 ENSMUST00020181676.1 Gm55952 (from geneSymbol) LF196014 uc288wcc.1 uc288wcc.1 
ENSMUST00020181677.1 Gm55172 ENSMUST00020181677.1 Gm55172 (from geneSymbol) uc288wcd.1 uc288wcd.1 
ENSMUST00020181678.1 Gm54685 ENSMUST00020181678.1 Gm54685 (from geneSymbol) DQ311494 uc288wce.1 uc288wce.1 
ENSMUST00020181679.1 Gm56283 ENSMUST00020181679.1 Gm56283 (from geneSymbol) uc288wcf.1 uc288wcf.1 
ENSMUST00020181680.1 Gm55801 ENSMUST00020181680.1 Gm55801 (from geneSymbol) uc288wcg.1 uc288wcg.1 
ENSMUST00020181681.1 Gm54741 ENSMUST00020181681.1 Gm54741 (from geneSymbol) uc288wch.1 uc288wch.1 
ENSMUST00020181682.1 Gm55368 ENSMUST00020181682.1 Gm55368 (from geneSymbol) AB352978 uc288wci.1 uc288wci.1 
ENSMUST00020181683.1 Gm55162 ENSMUST00020181683.1 Gm55162 (from geneSymbol) uc288wcj.1 uc288wcj.1 
ENSMUST00020181684.1 Gm54463 ENSMUST00020181684.1 Gm54463 (from geneSymbol) uc288wck.1 uc288wck.1 
ENSMUST00020181685.1 Gm55541 ENSMUST00020181685.1 Gm55541 (from geneSymbol) uc288wcl.1 uc288wcl.1 
ENSMUST00020181686.1 Gm54553 ENSMUST00020181686.1 Gm54553 (from geneSymbol) uc288wcm.1 uc288wcm.1 
ENSMUST00020181687.1 Gm55882 ENSMUST00020181687.1 Gm55882 (from geneSymbol) AK051099 uc288wcn.1 uc288wcn.1 
ENSMUST00020181688.1 Gm55182 ENSMUST00020181688.1 Gm55182 (from geneSymbol) uc288wco.1 uc288wco.1 
ENSMUST00020181689.1 Gm54871 ENSMUST00020181689.1 Gm54871 (from geneSymbol) uc288wcp.1 uc288wcp.1 
ENSMUST00020181690.1 Gm56264 ENSMUST00020181690.1 Gm56264 (from geneSymbol) uc288wcq.1 uc288wcq.1 
ENSMUST00020181691.1 Mir9b-1 ENSMUST00020181691.1 microRNA 9b-1 (from RefSeq NR_162800.1) NR_162800 uc288wcr.1 microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. uc288wcr.1 
ENSMUST00020181692.1 Gm54347 ENSMUST00020181692.1 Gm54347 (from geneSymbol) uc288wcs.1 uc288wcs.1 
ENSMUST00020181693.1 Gm55161 ENSMUST00020181693.1 Gm55161 (from geneSymbol) LF200518 uc288wct.1 uc288wct.1 
ENSMUST00020181694.1 Gm56404 ENSMUST00020181694.1 Gm56404 (from geneSymbol) LF196686 uc288wcu.1 uc288wcu.1 
ENSMUST00020181695.1 Gm55553 ENSMUST00020181695.1 Gm55553 (from geneSymbol) uc288wcv.1 uc288wcv.1 
ENSMUST00020181696.1 Gm56455 ENSMUST00020181696.1 Gm56455 (from geneSymbol) uc288wcw.1 uc288wcw.1 
ENSMUST00020181697.1 Gm54930 ENSMUST00020181697.1 Gm54930 (from geneSymbol) uc288wcx.1 uc288wcx.1 
ENSMUST00020181698.1 Gm55687 ENSMUST00020181698.1 Gm55687 (from geneSymbol) uc288wcy.1 uc288wcy.1 
ENSMUST00020181699.1 Gm55096 ENSMUST00020181699.1 Gm55096 (from geneSymbol) LF234689 uc288wcz.1 uc288wcz.1 
ENSMUST00020181700.1 Gm54837 ENSMUST00020181700.1 Gm54837 (from geneSymbol) uc288wda.1 uc288wda.1 
ENSMUST00020181701.1 Gm56101 ENSMUST00020181701.1 Gm56101 (from geneSymbol) DQ541194 uc288wdb.1 uc288wdb.1 
ENSMUST00020181702.1 Gm54729 ENSMUST00020181702.1 Gm54729 (from geneSymbol) uc288wdc.1 uc288wdc.1 
ENSMUST00020181703.1 Gm55329 ENSMUST00020181703.1 Gm55329 (from geneSymbol) uc288wdd.1 uc288wdd.1 
ENSMUST00020181704.1 Gm56416 ENSMUST00020181704.1 Gm56416 (from geneSymbol) uc288wde.1 uc288wde.1 
ENSMUST00020181705.1 Gm56472 ENSMUST00020181705.1 Gm56472 (from geneSymbol) uc288wdf.1 uc288wdf.1 
ENSMUST00020181706.1 Gm55527 ENSMUST00020181706.1 Gm55527 (from geneSymbol) uc288wdg.1 uc288wdg.1 
ENSMUST00020181707.1 Gm26379 ENSMUST00020181707.1 Gm26379 (from geneSymbol) uc288wdh.1 uc288wdh.1 
ENSMUST00020181708.1 Gm55564 ENSMUST00020181708.1 Gm55564 (from geneSymbol) uc288wdi.1 uc288wdi.1 
ENSMUST00020181709.1 Gm55468 ENSMUST00020181709.1 Gm55468 (from geneSymbol) uc288wdj.1 uc288wdj.1 
ENSMUST00020181710.1 Gm54694 ENSMUST00020181710.1 Gm54694 (from geneSymbol) uc288wdk.1 uc288wdk.1 
ENSMUST00020181711.1 Gm54562 ENSMUST00020181711.1 Gm54562 (from geneSymbol) uc288wdl.1 uc288wdl.1 
ENSMUST00020181712.1 Gm54713 ENSMUST00020181712.1 Gm54713 (from geneSymbol) uc288wdm.1 uc288wdm.1 
ENSMUST00020181713.1 Gm55147 ENSMUST00020181713.1 Gm55147 (from geneSymbol) uc288wdn.1 uc288wdn.1 
ENSMUST00020181714.1 Gm55416 ENSMUST00020181714.1 Gm55416 (from geneSymbol) LF204729 uc288wdo.1 uc288wdo.1 
ENSMUST00020181715.1 ENSMUSG00002075400 ENSMUST00020181715.1 ENSMUSG00002075400 (from geneSymbol) uc288wdp.1 uc288wdp.1 
ENSMUST00020181716.1 Gm55061 ENSMUST00020181716.1 Gm55061 (from geneSymbol) uc288wdq.1 uc288wdq.1 
ENSMUST00020181717.1 Gm54884 ENSMUST00020181717.1 Gm54884 (from geneSymbol) uc288wdr.1 uc288wdr.1 
ENSMUST00020181718.1 Gm56154 ENSMUST00020181718.1 Gm56154 (from geneSymbol) uc288wds.1 uc288wds.1 
ENSMUST00020181719.1 Gm55813 ENSMUST00020181719.1 Gm55813 (from geneSymbol) DQ311494 uc288wdt.1 uc288wdt.1 
ENSMUST00020181720.1 Gm54844 ENSMUST00020181720.1 Gm54844 (from geneSymbol) uc288wdu.1 uc288wdu.1 
ENSMUST00020181721.1 Gm55408 ENSMUST00020181721.1 Gm55408 (from geneSymbol) uc288wdv.1 uc288wdv.1 
ENSMUST00020181722.1 Gm56056 ENSMUST00020181722.1 Gm56056 (from geneSymbol) uc288wdw.1 uc288wdw.1 
ENSMUST00020181723.1 Gm55192 ENSMUST00020181723.1 Gm55192 (from geneSymbol) uc288wdx.1 uc288wdx.1 
ENSMUST00020181724.1 Gm55250 ENSMUST00020181724.1 Gm55250 (from geneSymbol) uc288wdy.1 uc288wdy.1 
ENSMUST00020181725.1 Gm55196 ENSMUST00020181725.1 Gm55196 (from geneSymbol) uc288wdz.1 uc288wdz.1 
ENSMUST00020181726.1 Gm55019 ENSMUST00020181726.1 Gm55019 (from geneSymbol) uc288wea.1 uc288wea.1 
ENSMUST00020181727.1 Gm55365 ENSMUST00020181727.1 Gm55365 (from geneSymbol) uc288web.1 uc288web.1 
ENSMUST00020181728.1 Gm54664 ENSMUST00020181728.1 Gm54664 (from geneSymbol) uc288wec.1 uc288wec.1 
ENSMUST00020181729.1 Gm54726 ENSMUST00020181729.1 Gm54726 (from geneSymbol) uc288wed.1 uc288wed.1 
ENSMUST00020181730.1 Gm54900 ENSMUST00020181730.1 Gm54900 (from geneSymbol) uc288wee.1 uc288wee.1 
ENSMUST00020181731.1 Gm56119 ENSMUST00020181731.1 Gm56119 (from geneSymbol) uc288wef.1 uc288wef.1 
ENSMUST00020181732.1 Gm55853 ENSMUST00020181732.1 Gm55853 (from geneSymbol) uc288weg.1 uc288weg.1 
ENSMUST00020181733.1 Gm56156 ENSMUST00020181733.1 Gm56156 (from geneSymbol) uc288weh.1 uc288weh.1 
ENSMUST00020181734.1 Gm55027 ENSMUST00020181734.1 Gm55027 (from geneSymbol) uc288wei.1 uc288wei.1 
ENSMUST00020181735.1 Gm54710 ENSMUST00020181735.1 Gm54710 (from geneSymbol) uc288wej.1 uc288wej.1 
ENSMUST00020181736.1 Gm55201 ENSMUST00020181736.1 Gm55201 (from geneSymbol) uc288wek.1 uc288wek.1 
ENSMUST00020181737.1 Gm55265 ENSMUST00020181737.1 Gm55265 (from geneSymbol) uc288wel.1 uc288wel.1 
ENSMUST00020181738.1 Gm56016 ENSMUST00020181738.1 Gm56016 (from geneSymbol) LF194880 uc288wem.1 uc288wem.1 
ENSMUST00020181739.1 Snord14e ENSMUST00020181739.1 small nucleolar RNA, C/D box 14E (from RefSeq NR_028275.1) NR_028275 uc288wen.1 uc288wen.1 
ENSMUST00020181740.1 Gm56258 ENSMUST00020181740.1 Gm56258 (from geneSymbol) uc288weo.1 uc288weo.1 
ENSMUST00020181741.1 Gm54380 ENSMUST00020181741.1 Gm54380 (from geneSymbol) uc288wep.1 uc288wep.1 
ENSMUST00020181742.1 Gm56375 ENSMUST00020181742.1 Gm56375 (from geneSymbol) uc288weq.1 uc288weq.1 
ENSMUST00020181743.1 Gm55505 ENSMUST00020181743.1 Gm55505 (from geneSymbol) uc288wer.1 uc288wer.1 
ENSMUST00020181744.1 Gm55457 ENSMUST00020181744.1 Gm55457 (from geneSymbol) uc288wes.1 uc288wes.1 
ENSMUST00020181745.1 Gm55556 ENSMUST00020181745.1 Gm55556 (from geneSymbol) uc288wet.1 uc288wet.1 
ENSMUST00020181746.1 Gm55383 ENSMUST00020181746.1 Gm55383 (from geneSymbol) DQ311494 uc288weu.1 uc288weu.1 
ENSMUST00020181747.1 Gm56168 ENSMUST00020181747.1 Gm56168 (from geneSymbol) uc288wev.1 uc288wev.1 
ENSMUST00020181748.1 Gm54698 ENSMUST00020181748.1 Gm54698 (from geneSymbol) uc288wew.1 uc288wew.1 
ENSMUST00020181749.1 Gm56054 ENSMUST00020181749.1 Gm56054 (from geneSymbol) uc288wex.1 uc288wex.1 
ENSMUST00020181750.1 Gm55747 ENSMUST00020181750.1 Gm55747 (from geneSymbol) LF198895 uc288wey.1 uc288wey.1 
ENSMUST00020181751.1 Gm55496 ENSMUST00020181751.1 Gm55496 (from geneSymbol) uc288wez.1 uc288wez.1 
ENSMUST00020181752.1 Gm55056 ENSMUST00020181752.1 Gm55056 (from geneSymbol) uc288wfa.1 uc288wfa.1 
ENSMUST00020181753.1 Gm54866 ENSMUST00020181753.1 Gm54866 (from geneSymbol) uc288wfb.1 uc288wfb.1 
ENSMUST00020181754.1 Gm55445 ENSMUST00020181754.1 Gm55445 (from geneSymbol) uc288wfc.1 uc288wfc.1 
ENSMUST00020181755.1 Gm54893 ENSMUST00020181755.1 Gm54893 (from geneSymbol) uc288wfd.1 uc288wfd.1 
ENSMUST00020181756.1 Gm56051 ENSMUST00020181756.1 Gm56051 (from geneSymbol) uc288wfe.1 uc288wfe.1 
ENSMUST00020181757.1 Gm54688 ENSMUST00020181757.1 Gm54688 (from geneSymbol) uc288wff.1 uc288wff.1 
ENSMUST00020181758.1 Gm54454 ENSMUST00020181758.1 Gm54454 (from geneSymbol) uc288wfg.1 uc288wfg.1 
ENSMUST00020181759.1 Gm55012 ENSMUST00020181759.1 Gm55012 (from geneSymbol) uc288wfh.1 uc288wfh.1 
ENSMUST00020181760.1 Gm56433 ENSMUST00020181760.1 Gm56433 (from geneSymbol) AK015962 uc288wfi.1 uc288wfi.1 
ENSMUST00020181761.1 Gm55191 ENSMUST00020181761.1 Gm55191 (from geneSymbol) BC027560 uc288wfj.1 uc288wfj.1 
ENSMUST00020181762.1 Gm54807 ENSMUST00020181762.1 Gm54807 (from geneSymbol) uc288wfk.1 uc288wfk.1 
ENSMUST00020181763.1 Gm55255 ENSMUST00020181763.1 Gm55255 (from geneSymbol) AB351420 uc288wfl.1 uc288wfl.1 
ENSMUST00020181764.1 Gm55697 ENSMUST00020181764.1 Gm55697 (from geneSymbol) uc288wfm.1 uc288wfm.1 
ENSMUST00020181765.1 Gm56486 ENSMUST00020181765.1 Gm56486 (from geneSymbol) uc288wfn.1 uc288wfn.1 
ENSMUST00020181766.1 Gm55466 ENSMUST00020181766.1 Gm55466 (from geneSymbol) uc288wfo.1 uc288wfo.1 
ENSMUST00020181767.1 Gm54594 ENSMUST00020181767.1 Gm54594 (from geneSymbol) uc288wfp.1 uc288wfp.1 
ENSMUST00020181768.1 Gm55388 ENSMUST00020181768.1 Gm55388 (from geneSymbol) uc288wfq.1 uc288wfq.1 
ENSMUST00020181769.1 Gm54605 ENSMUST00020181769.1 Gm54605 (from geneSymbol) uc288wfr.1 uc288wfr.1 
ENSMUST00020181770.1 Gm54613 ENSMUST00020181770.1 Gm54613 (from geneSymbol) uc288wfs.1 uc288wfs.1 
ENSMUST00020181771.1 Gm55660 ENSMUST00020181771.1 Gm55660 (from geneSymbol) DQ311494 uc288wft.1 uc288wft.1 
ENSMUST00020181772.1 Gm56434 ENSMUST00020181772.1 Gm56434 (from geneSymbol) uc288wfu.1 uc288wfu.1 
ENSMUST00020181773.1 Gm56485 ENSMUST00020181773.1 Gm56485 (from geneSymbol) uc288wfv.1 uc288wfv.1 
ENSMUST00020181774.1 Gm55951 ENSMUST00020181774.1 Gm55951 (from geneSymbol) uc288wfw.1 uc288wfw.1 
ENSMUST00020181775.1 Gm55362 ENSMUST00020181775.1 Gm55362 (from geneSymbol) uc288wfx.1 uc288wfx.1 
ENSMUST00020181776.1 Gm56170 ENSMUST00020181776.1 Gm56170 (from geneSymbol) uc288wfy.1 uc288wfy.1 
ENSMUST00020181777.1 Gm55424 ENSMUST00020181777.1 Gm55424 (from geneSymbol) DQ311494 uc288wfz.1 uc288wfz.1 
ENSMUST00020181778.1 Gm55517 ENSMUST00020181778.1 Gm55517 (from geneSymbol) uc288wga.1 uc288wga.1 
ENSMUST00020181779.1 Gm56070 ENSMUST00020181779.1 Gm56070 (from geneSymbol) uc288wgb.1 uc288wgb.1 
ENSMUST00020181780.1 Gm56267 ENSMUST00020181780.1 Gm56267 (from geneSymbol) uc288wgc.1 uc288wgc.1 
ENSMUST00020181781.1 Gm56141 ENSMUST00020181781.1 Gm56141 (from geneSymbol) uc288wgd.1 uc288wgd.1 
ENSMUST00020181782.1 Gm55536 ENSMUST00020181782.1 Gm55536 (from geneSymbol) AB352978 uc288wge.1 uc288wge.1 
ENSMUST00020181783.1 Gm55278 ENSMUST00020181783.1 Gm55278 (from geneSymbol) uc288wgf.1 uc288wgf.1 
ENSMUST00020181784.1 Gm55920 ENSMUST00020181784.1 Gm55920 (from geneSymbol) uc288wgg.1 uc288wgg.1 
ENSMUST00020181785.1 Gm55617 ENSMUST00020181785.1 Gm55617 (from geneSymbol) uc288wgh.1 uc288wgh.1 
ENSMUST00020181786.1 Gm56407 ENSMUST00020181786.1 Gm56407 (from geneSymbol) uc288wgi.1 uc288wgi.1 
ENSMUST00020181787.1 Gm55736 ENSMUST00020181787.1 Gm55736 (from geneSymbol) uc288wgj.1 uc288wgj.1 
ENSMUST00020181788.1 Gm55296 ENSMUST00020181788.1 Gm55296 (from geneSymbol) uc288wgk.1 uc288wgk.1 
ENSMUST00020181789.1 Gm54891 ENSMUST00020181789.1 Gm54891 (from geneSymbol) uc288wgl.1 uc288wgl.1 
ENSMUST00020181790.1 Gm55355 ENSMUST00020181790.1 Gm55355 (from geneSymbol) uc288wgm.1 uc288wgm.1 
ENSMUST00020181791.1 Gm54843 ENSMUST00020181791.1 Gm54843 (from geneSymbol) uc288wgn.1 uc288wgn.1 
ENSMUST00020181792.1 Gm55277 ENSMUST00020181792.1 Gm55277 (from geneSymbol) AB350056 uc288wgo.1 uc288wgo.1 
ENSMUST00020181793.1 ENSMUSG00002074899 ENSMUST00020181793.1 ENSMUSG00002074899 (from geneSymbol) AB352500 uc288wgp.1 uc288wgp.1 
ENSMUST00020181794.1 Gm54853 ENSMUST00020181794.1 Gm54853 (from geneSymbol) uc288wgq.1 uc288wgq.1 
ENSMUST00020181795.1 Gm55332 ENSMUST00020181795.1 Gm55332 (from geneSymbol) uc288wgr.1 uc288wgr.1 
ENSMUST00020181796.1 Gm56232 ENSMUST00020181796.1 Gm56232 (from geneSymbol) uc288wgs.1 uc288wgs.1 
ENSMUST00020181797.1 Gm56033 ENSMUST00020181797.1 Gm56033 (from geneSymbol) DQ311494 uc288wgt.1 uc288wgt.1 
ENSMUST00020181798.1 Gm25424 ENSMUST00020181798.1 Gm25424 (from geneSymbol) uc288wgu.1 uc288wgu.1 
ENSMUST00020181799.1 Gm56117 ENSMUST00020181799.1 Gm56117 (from geneSymbol) uc288wgv.1 uc288wgv.1 
ENSMUST00020181800.1 Gm55188 ENSMUST00020181800.1 Gm55188 (from geneSymbol) uc288wgw.1 uc288wgw.1 
ENSMUST00020181801.1 Gm55352 ENSMUST00020181801.1 Gm55352 (from geneSymbol) uc288wgx.1 uc288wgx.1 
ENSMUST00020181802.1 Gm55292 ENSMUST00020181802.1 Gm55292 (from geneSymbol) uc288wgy.1 uc288wgy.1 
ENSMUST00020181803.1 Gm55193 ENSMUST00020181803.1 Gm55193 (from geneSymbol) uc288wgz.1 uc288wgz.1 
ENSMUST00020181804.1 Gm55325 ENSMUST00020181804.1 Gm55325 (from geneSymbol) uc288wha.1 uc288wha.1 
ENSMUST00020181805.1 Gm55098 ENSMUST00020181805.1 Gm55098 (from geneSymbol) AB352120 uc288whb.1 uc288whb.1 
ENSMUST00020181806.1 Gm54990 ENSMUST00020181806.1 Gm54990 (from geneSymbol) DQ311494 uc288whc.1 uc288whc.1 
ENSMUST00020181807.1 Gm56437 ENSMUST00020181807.1 Gm56437 (from geneSymbol) uc288whd.1 uc288whd.1 
ENSMUST00020181808.1 Gm54690 ENSMUST00020181808.1 Gm54690 (from geneSymbol) uc288whe.1 uc288whe.1 
ENSMUST00020181809.1 Gm55202 ENSMUST00020181809.1 Gm55202 (from geneSymbol) uc288whf.1 uc288whf.1 
ENSMUST00020181810.1 Gm56313 ENSMUST00020181810.1 Gm56313 (from geneSymbol) uc288whg.1 uc288whg.1 
ENSMUST00020181811.1 Gm55303 ENSMUST00020181811.1 Gm55303 (from geneSymbol) AB352500 uc288whh.1 uc288whh.1 
ENSMUST00020181812.1 Gm56394 ENSMUST00020181812.1 Gm56394 (from geneSymbol) uc288whi.1 uc288whi.1 
ENSMUST00020181813.1 Gm54446 ENSMUST00020181813.1 Gm54446 (from geneSymbol) uc288whj.1 uc288whj.1 
ENSMUST00020181814.1 Gm56360 ENSMUST00020181814.1 Gm56360 (from geneSymbol) uc288whk.1 uc288whk.1 
ENSMUST00020181815.1 Gm55224 ENSMUST00020181815.1 Gm55224 (from geneSymbol) uc288whl.1 uc288whl.1 
ENSMUST00020181816.1 Gm54849 ENSMUST00020181816.1 Gm54849 (from geneSymbol) DQ541194 uc288whm.1 uc288whm.1 
ENSMUST00020181817.1 Gm56027 ENSMUST00020181817.1 Gm56027 (from geneSymbol) uc288whn.1 uc288whn.1 
ENSMUST00020181818.1 Gm54997 ENSMUST00020181818.1 Gm54997 (from geneSymbol) uc288who.1 uc288who.1 
ENSMUST00020181819.1 Gm54666 ENSMUST00020181819.1 Gm54666 (from geneSymbol) uc288whp.1 uc288whp.1 
ENSMUST00020181820.1 Gm55384 ENSMUST00020181820.1 Gm55384 (from geneSymbol) uc288whq.1 uc288whq.1 
ENSMUST00020181821.1 Gm54721 ENSMUST00020181821.1 Gm54721 (from geneSymbol) uc288whr.1 uc288whr.1 
ENSMUST00020181822.1 Gm55528 ENSMUST00020181822.1 Gm55528 (from geneSymbol) uc288whs.1 uc288whs.1 
ENSMUST00020181823.1 Gm55050 ENSMUST00020181823.1 Gm55050 (from geneSymbol) uc288wht.1 uc288wht.1 
ENSMUST00020181824.1 Gm56192 ENSMUST00020181824.1 Gm56192 (from geneSymbol) uc288whu.1 uc288whu.1 
ENSMUST00020181825.1 Gm56028 ENSMUST00020181825.1 Gm56028 (from geneSymbol) uc288whv.1 uc288whv.1 
ENSMUST00020181826.1 Gm54519 ENSMUST00020181826.1 Gm54519 (from geneSymbol) uc288whw.1 uc288whw.1 
ENSMUST00020181827.1 Gm54422 ENSMUST00020181827.1 Gm54422 (from geneSymbol) uc288whx.1 uc288whx.1 
ENSMUST00020181828.1 Gm55523 ENSMUST00020181828.1 Gm55523 (from geneSymbol) BC095948 uc288why.1 uc288why.1 
ENSMUST00020181829.1 Gm56432 ENSMUST00020181829.1 Gm56432 (from geneSymbol) uc288whz.1 uc288whz.1 
ENSMUST00020181830.1 Gm55988 ENSMUST00020181830.1 Gm55988 (from geneSymbol) uc288wia.1 uc288wia.1 
ENSMUST00020181831.1 Gm56367 ENSMUST00020181831.1 Gm56367 (from geneSymbol) uc288wib.1 uc288wib.1 
ENSMUST00020181832.1 Gm55577 ENSMUST00020181832.1 Gm55577 (from geneSymbol) uc288wic.1 uc288wic.1 
ENSMUST00020181833.1 Gm55953 ENSMUST00020181833.1 Gm55953 (from geneSymbol) uc288wid.1 uc288wid.1 
ENSMUST00020181834.1 Gm55700 ENSMUST00020181834.1 Gm55700 (from geneSymbol) uc288wie.1 uc288wie.1 
ENSMUST00020181835.1 Gm55662 ENSMUST00020181835.1 Gm55662 (from geneSymbol) uc288wif.1 uc288wif.1 
ENSMUST00020181836.1 Gm54911 ENSMUST00020181836.1 Gm54911 (from geneSymbol) uc288wig.1 uc288wig.1 
ENSMUST00020181837.1 Gm54473 ENSMUST00020181837.1 Gm54473 (from geneSymbol) uc288wih.1 uc288wih.1 
ENSMUST00020181838.1 Gm56100 ENSMUST00020181838.1 Gm56100 (from geneSymbol) uc288wii.1 uc288wii.1 
ENSMUST00020181839.1 Gm54825 ENSMUST00020181839.1 Gm54825 (from geneSymbol) uc288wij.1 uc288wij.1 
ENSMUST00020181840.1 Gm56089 ENSMUST00020181840.1 Gm56089 (from geneSymbol) uc288wik.1 uc288wik.1 
ENSMUST00020181841.1 Gm55184 ENSMUST00020181841.1 Gm55184 (from geneSymbol) uc288wil.1 uc288wil.1 
ENSMUST00020181842.1 Gm55064 ENSMUST00020181842.1 Gm55064 (from geneSymbol) BC010710 uc288wim.1 uc288wim.1 
ENSMUST00020181843.1 Gm56009 ENSMUST00020181843.1 Gm56009 (from geneSymbol) uc288win.1 uc288win.1 
ENSMUST00020181844.1 Gm56110 ENSMUST00020181844.1 Gm56110 (from geneSymbol) uc288wio.1 uc288wio.1 
ENSMUST00020181845.1 Gm56126 ENSMUST00020181845.1 Gm56126 (from geneSymbol) uc288wip.1 uc288wip.1 
ENSMUST00020181846.1 Gm55491 ENSMUST00020181846.1 Gm55491 (from geneSymbol) uc288wiq.1 uc288wiq.1 
ENSMUST00020181847.1 Gm54994 ENSMUST00020181847.1 Gm54994 (from geneSymbol) AB352541 uc288wir.1 uc288wir.1 
ENSMUST00020181848.1 Gm55578 ENSMUST00020181848.1 Gm55578 (from geneSymbol) uc288wis.1 uc288wis.1 
ENSMUST00020181849.1 Gm55962 ENSMUST00020181849.1 Gm55962 (from geneSymbol) uc288wit.1 uc288wit.1 
ENSMUST00020181850.1 Gm55915 ENSMUST00020181850.1 Gm55915 (from geneSymbol) LF194709 uc288wiu.1 uc288wiu.1 
ENSMUST00020181851.1 Gm55606 ENSMUST00020181851.1 Gm55606 (from geneSymbol) uc288wiv.1 uc288wiv.1 
ENSMUST00020181852.1 Gm55135 ENSMUST00020181852.1 Gm55135 (from geneSymbol) LF192824 uc288wiw.1 uc288wiw.1 
ENSMUST00020181853.1 Gm55451 ENSMUST00020181853.1 Gm55451 (from geneSymbol) uc288wix.1 uc288wix.1 
ENSMUST00020181854.1 Gm54873 ENSMUST00020181854.1 Gm54873 (from geneSymbol) uc288wiy.1 uc288wiy.1 
ENSMUST00020181855.1 Gm54370 ENSMUST00020181855.1 Gm54370 (from geneSymbol) uc288wiz.1 uc288wiz.1 
ENSMUST00020181856.1 Gm56008 ENSMUST00020181856.1 Gm56008 (from geneSymbol) uc288wja.1 uc288wja.1 
ENSMUST00020181857.1 Gm56452 ENSMUST00020181857.1 Gm56452 (from geneSymbol) uc288wjb.1 uc288wjb.1 
ENSMUST00020181858.1 Gm56339 ENSMUST00020181858.1 Gm56339 (from geneSymbol) uc288wjc.1 uc288wjc.1 
ENSMUST00020181859.1 Gm55849 ENSMUST00020181859.1 Gm55849 (from geneSymbol) uc288wjd.1 uc288wjd.1 
ENSMUST00020181860.1 Gm54643 ENSMUST00020181860.1 Gm54643 (from geneSymbol) uc288wje.1 uc288wje.1 
ENSMUST00020181861.1 Gm55057 ENSMUST00020181861.1 Gm55057 (from geneSymbol) uc288wjf.1 uc288wjf.1 
ENSMUST00020181862.1 Gm56066 ENSMUST00020181862.1 Gm56066 (from geneSymbol) uc288wjg.1 uc288wjg.1 
ENSMUST00020181863.1 Gm55756 ENSMUST00020181863.1 Gm55756 (from geneSymbol) uc288wjh.1 uc288wjh.1 
ENSMUST00020181864.1 Gm55684 ENSMUST00020181864.1 Gm55684 (from geneSymbol) uc288wji.1 uc288wji.1 
ENSMUST00020181865.1 Gm54632 ENSMUST00020181865.1 Gm54632 (from geneSymbol) uc288wjj.1 uc288wjj.1 
ENSMUST00020181866.1 Gm55680 ENSMUST00020181866.1 Gm55680 (from geneSymbol) uc288wjk.1 uc288wjk.1 
ENSMUST00020181867.1 Gm54371 ENSMUST00020181867.1 Gm54371 (from geneSymbol) uc288wjl.1 uc288wjl.1 
ENSMUST00020181868.1 Gm56473 ENSMUST00020181868.1 Gm56473 (from geneSymbol) uc288wjm.1 uc288wjm.1 
ENSMUST00020181869.1 Gm54750 ENSMUST00020181869.1 Gm54750 (from geneSymbol) uc288wjn.1 uc288wjn.1 
ENSMUST00020181870.1 Gm54474 ENSMUST00020181870.1 Gm54474 (from geneSymbol) uc288wjo.1 uc288wjo.1 
ENSMUST00020181871.1 Gm55473 ENSMUST00020181871.1 Gm55473 (from geneSymbol) uc288wjp.1 uc288wjp.1 
ENSMUST00020181872.1 Gm55339 ENSMUST00020181872.1 Gm55339 (from geneSymbol) uc288wjq.1 uc288wjq.1 
ENSMUST00020181873.1 Gm55076 ENSMUST00020181873.1 Gm55076 (from geneSymbol) uc288wjr.1 uc288wjr.1 
ENSMUST00020181874.1 Gm55622 ENSMUST00020181874.1 Gm55622 (from geneSymbol) uc288wjs.1 uc288wjs.1 
ENSMUST00020181875.1 Gm55905 ENSMUST00020181875.1 Gm55905 (from geneSymbol) uc288wjt.1 uc288wjt.1 
ENSMUST00020181876.1 Gm55195 ENSMUST00020181876.1 Gm55195 (from geneSymbol) uc288wju.1 uc288wju.1 
ENSMUST00020181877.1 Gm54560 ENSMUST00020181877.1 Gm54560 (from geneSymbol) uc288wjv.1 uc288wjv.1 
ENSMUST00020181878.1 Gm54356 ENSMUST00020181878.1 Gm54356 (from geneSymbol) uc288wjw.1 uc288wjw.1 
ENSMUST00020181879.1 Gm56456 ENSMUST00020181879.1 Gm56456 (from geneSymbol) uc288wjx.1 uc288wjx.1 
ENSMUST00020181880.1 Gm55582 ENSMUST00020181880.1 Gm55582 (from geneSymbol) uc288wjy.1 uc288wjy.1 
ENSMUST00020181881.1 Gm55510 ENSMUST00020181881.1 Gm55510 (from geneSymbol) uc288wjz.1 uc288wjz.1 
ENSMUST00020181882.1 Gm55386 ENSMUST00020181882.1 Gm55386 (from geneSymbol) uc288wka.1 uc288wka.1 
ENSMUST00020181883.1 Gm55461 ENSMUST00020181883.1 Gm55461 (from geneSymbol) uc288wkb.1 uc288wkb.1 
ENSMUST00020181884.1 Gm56469 ENSMUST00020181884.1 Gm56469 (from geneSymbol) uc288wkc.1 uc288wkc.1 
ENSMUST00020181885.1 Gm54908 ENSMUST00020181885.1 Gm54908 (from geneSymbol) LF198259 uc288wkd.1 uc288wkd.1 
ENSMUST00020181886.1 Gm55141 ENSMUST00020181886.1 Gm55141 (from geneSymbol) uc288wke.1 uc288wke.1 
ENSMUST00020181887.1 Gm55784 ENSMUST00020181887.1 Gm55784 (from geneSymbol) uc288wkf.1 uc288wkf.1 
ENSMUST00020181888.1 Gm55836 ENSMUST00020181888.1 Gm55836 (from geneSymbol) DQ311523 uc288wkg.1 uc288wkg.1 
ENSMUST00020181889.1 Gm55892 ENSMUST00020181889.1 Gm55892 (from geneSymbol) uc288wkh.1 uc288wkh.1 
ENSMUST00020181890.1 Gm55981 ENSMUST00020181890.1 Gm55981 (from geneSymbol) uc288wki.1 uc288wki.1 
ENSMUST00020181891.1 Gm54793 ENSMUST00020181891.1 Gm54793 (from geneSymbol) uc288wkj.1 uc288wkj.1 
ENSMUST00020181892.1 Gm55914 ENSMUST00020181892.1 Gm55914 (from geneSymbol) uc288wkk.1 uc288wkk.1 
ENSMUST00020181893.1 Gm26057 ENSMUST00020181893.1 Gm26057 (from geneSymbol) uc288wkl.1 uc288wkl.1 
ENSMUST00020181894.1 Gm55706 ENSMUST00020181894.1 Gm55706 (from geneSymbol) uc288wkm.1 uc288wkm.1 
ENSMUST00020181895.1 Gm55600 ENSMUST00020181895.1 Gm55600 (from geneSymbol) LF197818 uc288wkn.1 uc288wkn.1 
ENSMUST00020181896.1 Gm55512 ENSMUST00020181896.1 Gm55512 (from geneSymbol) DQ311494 uc288wko.1 uc288wko.1 
ENSMUST00020181897.1 Gm56299 ENSMUST00020181897.1 Gm56299 (from geneSymbol) uc288wkp.1 uc288wkp.1 
ENSMUST00020181898.1 Gm55585 ENSMUST00020181898.1 Gm55585 (from geneSymbol) AK051106 uc288wkq.1 uc288wkq.1 
ENSMUST00020181899.1 Gm55852 ENSMUST00020181899.1 Gm55852 (from geneSymbol) uc288wkr.1 uc288wkr.1 
ENSMUST00020181900.1 Gm55631 ENSMUST00020181900.1 Gm55631 (from geneSymbol) DQ543817 uc288wks.1 uc288wks.1 
ENSMUST00020181901.1 Gm54616 ENSMUST00020181901.1 Gm54616 (from geneSymbol) uc288wkt.1 uc288wkt.1 
ENSMUST00020181902.1 Gm55163 ENSMUST00020181902.1 Gm55163 (from geneSymbol) uc288wku.1 uc288wku.1 
ENSMUST00020181903.1 Gm56443 ENSMUST00020181903.1 Gm56443 (from geneSymbol) uc288wkv.1 uc288wkv.1 
ENSMUST00020181904.1 Gm54412 ENSMUST00020181904.1 Gm54412 (from geneSymbol) uc288wkw.1 uc288wkw.1 
ENSMUST00020181905.1 Gm54625 ENSMUST00020181905.1 Gm54625 (from geneSymbol) uc288wkx.1 uc288wkx.1 
ENSMUST00020181906.1 Gm54802 ENSMUST00020181906.1 Gm54802 (from geneSymbol) uc288wky.1 uc288wky.1 
ENSMUST00020181907.1 Gm54653 ENSMUST00020181907.1 Gm54653 (from geneSymbol) uc288wkz.1 uc288wkz.1 
ENSMUST00020181908.1 Gm54341 ENSMUST00020181908.1 Gm54341 (from geneSymbol) DQ311494 uc288wla.1 uc288wla.1 
ENSMUST00020181909.1 Gm55361 ENSMUST00020181909.1 Gm55361 (from geneSymbol) uc288wlb.1 uc288wlb.1 
ENSMUST00020181910.1 Gm56041 ENSMUST00020181910.1 Gm56041 (from geneSymbol) U20368 uc288wlc.1 uc288wlc.1 
ENSMUST00020181911.1 Gm54999 ENSMUST00020181911.1 Gm54999 (from geneSymbol) LF199312 uc288wld.1 uc288wld.1 
ENSMUST00020181912.1 Gm55638 ENSMUST00020181912.1 Gm55638 (from geneSymbol) uc288wle.1 uc288wle.1 
ENSMUST00020181913.1 Gm55111 ENSMUST00020181913.1 Gm55111 (from geneSymbol) LF199329 uc288wlf.1 uc288wlf.1 
ENSMUST00020181914.1 Gm54549 ENSMUST00020181914.1 Gm54549 (from geneSymbol) AB352978 uc288wlg.1 uc288wlg.1 
ENSMUST00020181915.1 Gm25820 ENSMUST00020181915.1 Gm25820 (from geneSymbol) uc288wlh.1 uc288wlh.1 
ENSMUST00020181916.1 Gm55164 ENSMUST00020181916.1 Gm55164 (from geneSymbol) LF199379 uc288wli.1 uc288wli.1 
ENSMUST00020181917.1 Gm56430 ENSMUST00020181917.1 Gm56430 (from geneSymbol) LF192526 uc288wlj.1 uc288wlj.1 
ENSMUST00020181918.1 Gm54570 ENSMUST00020181918.1 Gm54570 (from geneSymbol) uc288wlk.1 uc288wlk.1 
ENSMUST00020181919.1 Gm23823 ENSMUST00020181919.1 Gm23823 (from geneSymbol) uc288wll.1 uc288wll.1 
ENSMUST00020181920.1 Gm56017 ENSMUST00020181920.1 Gm56017 (from geneSymbol) uc288wlm.1 uc288wlm.1 
ENSMUST00020181921.1 Gm56247 ENSMUST00020181921.1 Gm56247 (from geneSymbol) uc288wln.1 uc288wln.1 
ENSMUST00020181922.1 Gm56147 ENSMUST00020181922.1 Gm56147 (from geneSymbol) uc288wlo.1 uc288wlo.1 
ENSMUST00020181923.1 Gm56184 ENSMUST00020181923.1 Gm56184 (from geneSymbol) uc288wlp.1 uc288wlp.1 
ENSMUST00020181924.1 Gm54665 ENSMUST00020181924.1 Gm54665 (from geneSymbol) uc288wlq.1 uc288wlq.1 
ENSMUST00020181925.1 Gm56308 ENSMUST00020181925.1 Gm56308 (from geneSymbol) uc288wlr.1 uc288wlr.1 
ENSMUST00020181926.1 Gm54452 ENSMUST00020181926.1 Gm54452 (from geneSymbol) LF199427 uc288wls.1 uc288wls.1 
ENSMUST00020181927.1 Gm55254 ENSMUST00020181927.1 Gm55254 (from geneSymbol) uc288wlt.1 uc288wlt.1 
ENSMUST00020181928.1 Gm55467 ENSMUST00020181928.1 Gm55467 (from geneSymbol) DQ311494 uc288wlu.1 uc288wlu.1 
ENSMUST00020181929.1 Gm55134 ENSMUST00020181929.1 Gm55134 (from geneSymbol) uc288wlv.1 uc288wlv.1 
ENSMUST00020181930.1 Gm55031 ENSMUST00020181930.1 Gm55031 (from geneSymbol) uc288wlw.1 uc288wlw.1 
ENSMUST00020181931.1 Gm54712 ENSMUST00020181931.1 Gm54712 (from geneSymbol) uc288wlx.1 uc288wlx.1 
ENSMUST00020181932.1 Gm55803 ENSMUST00020181932.1 Gm55803 (from geneSymbol) uc288wly.1 uc288wly.1 
ENSMUST00020181933.1 Gm54502 ENSMUST00020181933.1 Gm54502 (from geneSymbol) AB352978 uc288wlz.1 uc288wlz.1 
ENSMUST00020181934.1 Gm55904 ENSMUST00020181934.1 Gm55904 (from geneSymbol) uc288wma.1 uc288wma.1 
ENSMUST00020181935.1 Gm56311 ENSMUST00020181935.1 Gm56311 (from geneSymbol) AB349944 uc288wmb.1 uc288wmb.1 
ENSMUST00020181936.1 Gm54537 ENSMUST00020181936.1 Gm54537 (from geneSymbol) uc288wmc.1 uc288wmc.1 
ENSMUST00020181937.1 Gm54708 ENSMUST00020181937.1 Gm54708 (from geneSymbol) uc288wmd.1 uc288wmd.1 
ENSMUST00020181938.1 Gm54924 ENSMUST00020181938.1 Gm54924 (from geneSymbol) AK042493 uc288wme.1 uc288wme.1 
ENSMUST00020181939.1 Gm55887 ENSMUST00020181939.1 Gm55887 (from geneSymbol) uc288wmf.1 uc288wmf.1 
ENSMUST00020181940.1 Gm54663 ENSMUST00020181940.1 Gm54663 (from geneSymbol) uc288wmg.1 uc288wmg.1 
ENSMUST00020181941.1 Gm54881 ENSMUST00020181941.1 Gm54881 (from geneSymbol) uc288wmh.1 uc288wmh.1 
ENSMUST00020181942.1 Gm55976 ENSMUST00020181942.1 Gm55976 (from geneSymbol) uc288wmi.1 uc288wmi.1 
ENSMUST00020181943.1 Gm55130 ENSMUST00020181943.1 Gm55130 (from geneSymbol) uc288wmj.1 uc288wmj.1 
ENSMUST00020181944.1 Gm54483 ENSMUST00020181944.1 Gm54483 (from geneSymbol) uc288wmk.1 uc288wmk.1 
ENSMUST00020181945.1 Gm56061 ENSMUST00020181945.1 Gm56061 (from geneSymbol) DQ311497 uc288wml.1 uc288wml.1 
ENSMUST00020181946.1 Gm54512 ENSMUST00020181946.1 Gm54512 (from geneSymbol) uc288wmm.1 uc288wmm.1 
ENSMUST00020181947.1 Gm54442 ENSMUST00020181947.1 Gm54442 (from geneSymbol) uc288wmn.1 uc288wmn.1 
ENSMUST00020181948.1 Gm55074 ENSMUST00020181948.1 Gm55074 (from geneSymbol) uc288wmo.1 uc288wmo.1 
ENSMUST00020181949.1 Gm55592 ENSMUST00020181949.1 Gm55592 (from geneSymbol) uc288wmp.1 uc288wmp.1 
ENSMUST00020181950.1 Gm55407 ENSMUST00020181950.1 Gm55407 (from geneSymbol) uc288wmq.1 uc288wmq.1 
ENSMUST00020181951.1 Gm55000 ENSMUST00020181951.1 Gm55000 (from geneSymbol) uc288wmr.1 uc288wmr.1 
ENSMUST00020181952.1 Gm56414 ENSMUST00020181952.1 Gm56414 (from geneSymbol) uc288wms.1 uc288wms.1 
ENSMUST00020181953.1 Gm54958 ENSMUST00020181953.1 Gm54958 (from geneSymbol) uc288wmt.1 uc288wmt.1 
ENSMUST00020181954.1 Gm55200 ENSMUST00020181954.1 Gm55200 (from geneSymbol) uc288wmu.1 uc288wmu.1 
ENSMUST00020181955.1 Gm54543 ENSMUST00020181955.1 Gm54543 (from geneSymbol) uc288wmv.1 uc288wmv.1 
ENSMUST00020181956.1 Gm56074 ENSMUST00020181956.1 Gm56074 (from geneSymbol) uc288wmw.1 uc288wmw.1 
ENSMUST00020181957.1 Gm55611 ENSMUST00020181957.1 Gm55611 (from geneSymbol) LF199595 uc288wmx.1 uc288wmx.1 
ENSMUST00020181958.1 Gm55508 ENSMUST00020181958.1 Gm55508 (from geneSymbol) uc288wmy.1 uc288wmy.1 
ENSMUST00020181959.1 Gm56220 ENSMUST00020181959.1 Gm56220 (from geneSymbol) uc288wmz.1 uc288wmz.1 
ENSMUST00020181960.1 Gm55010 ENSMUST00020181960.1 Gm55010 (from geneSymbol) DQ311494 uc288wna.1 uc288wna.1 
ENSMUST00020181961.1 Gm54557 ENSMUST00020181961.1 Gm54557 (from geneSymbol) uc288wnb.1 uc288wnb.1 
ENSMUST00020181962.1 Gm55616 ENSMUST00020181962.1 Gm55616 (from geneSymbol) uc288wnc.1 uc288wnc.1 
ENSMUST00020181963.1 Gm54462 ENSMUST00020181963.1 Gm54462 (from geneSymbol) uc288wnd.1 uc288wnd.1 
ENSMUST00020181964.1 Gm55602 ENSMUST00020181964.1 Gm55602 (from geneSymbol) DQ311494 uc288wne.1 uc288wne.1 
ENSMUST00020181965.1 Gm55429 ENSMUST00020181965.1 Gm55429 (from geneSymbol) uc288wnf.1 uc288wnf.1 
ENSMUST00020181966.1 Gm54459 ENSMUST00020181966.1 Gm54459 (from geneSymbol) uc288wng.1 uc288wng.1 
ENSMUST00020181967.1 Gm56406 ENSMUST00020181967.1 Gm56406 (from geneSymbol) uc288wnh.1 uc288wnh.1 
ENSMUST00020181968.1 Gm54987 ENSMUST00020181968.1 Gm54987 (from geneSymbol) AK028129 uc288wni.1 uc288wni.1 
ENSMUST00020181969.1 Gm54764 ENSMUST00020181969.1 Gm54764 (from geneSymbol) uc288wnj.1 uc288wnj.1 
ENSMUST00020181970.1 Gm56408 ENSMUST00020181970.1 Gm56408 (from geneSymbol) uc288wnk.1 uc288wnk.1 
ENSMUST00020181971.1 Gm54535 ENSMUST00020181971.1 Gm54535 (from geneSymbol) uc288wnl.1 uc288wnl.1 
ENSMUST00020181972.1 Gm56200 ENSMUST00020181972.1 Gm56200 (from geneSymbol) uc288wnm.1 uc288wnm.1 
ENSMUST00020181973.1 Gm55975 ENSMUST00020181973.1 Gm55975 (from geneSymbol) uc288wnn.1 uc288wnn.1 
ENSMUST00020181974.1 Gm54757 ENSMUST00020181974.1 Gm54757 (from geneSymbol) uc288wno.1 uc288wno.1 
ENSMUST00020181975.1 Gm56397 ENSMUST00020181975.1 Gm56397 (from geneSymbol) DQ311494 uc288wnp.1 uc288wnp.1 
ENSMUST00020181976.1 Gm55550 ENSMUST00020181976.1 Gm55550 (from geneSymbol) uc288wnq.1 uc288wnq.1 
ENSMUST00020181977.1 Gm55772 ENSMUST00020181977.1 Gm55772 (from geneSymbol) uc288wnr.1 uc288wnr.1 
ENSMUST00020181978.1 Gm55421 ENSMUST00020181978.1 Gm55421 (from geneSymbol) uc288wns.1 uc288wns.1 
ENSMUST00020181979.1 Gm55132 ENSMUST00020181979.1 Gm55132 (from geneSymbol) uc288wnt.1 uc288wnt.1 
ENSMUST00020181980.1 Gm54810 ENSMUST00020181980.1 Gm54810 (from geneSymbol) uc288wnu.1 uc288wnu.1 
ENSMUST00020181981.1 Gm54521 ENSMUST00020181981.1 Gm54521 (from geneSymbol) uc288wnv.1 uc288wnv.1 
ENSMUST00020181982.1 Gm55101 ENSMUST00020181982.1 Gm55101 (from geneSymbol) DQ311523 uc288wnw.1 uc288wnw.1 
ENSMUST00020181983.1 Gm55681 ENSMUST00020181983.1 Gm55681 (from geneSymbol) AB351420 uc288wnx.1 uc288wnx.1 
ENSMUST00020181984.1 Gm54969 ENSMUST00020181984.1 Gm54969 (from geneSymbol) uc288wny.1 uc288wny.1 
ENSMUST00020181985.1 Gm54447 ENSMUST00020181985.1 Gm54447 (from geneSymbol) uc288wnz.1 uc288wnz.1 
ENSMUST00020181986.1 Gm54411 ENSMUST00020181986.1 Gm54411 (from geneSymbol) uc288woa.1 uc288woa.1 
ENSMUST00020181987.1 Gm54856 ENSMUST00020181987.1 Gm54856 (from geneSymbol) uc288wob.1 uc288wob.1 
ENSMUST00020181988.1 Gm54541 ENSMUST00020181988.1 Gm54541 (from geneSymbol) LF195440 uc288woc.1 uc288woc.1 
ENSMUST00020181989.1 Gm55218 ENSMUST00020181989.1 Gm55218 (from geneSymbol) uc288wod.1 uc288wod.1 
ENSMUST00020181990.1 Gm55018 ENSMUST00020181990.1 Gm55018 (from geneSymbol) uc288woe.1 uc288woe.1 
ENSMUST00020181991.1 Gm55463 ENSMUST00020181991.1 Gm55463 (from geneSymbol) uc288wof.1 uc288wof.1 
ENSMUST00020181992.1 Gm55181 ENSMUST00020181992.1 Gm55181 (from geneSymbol) uc288wog.1 uc288wog.1 
ENSMUST00020181993.1 Gm55331 ENSMUST00020181993.1 Gm55331 (from geneSymbol) uc288woh.1 uc288woh.1 
ENSMUST00020181994.1 Gm54355 ENSMUST00020181994.1 Gm54355 (from geneSymbol) uc288woi.1 uc288woi.1 
ENSMUST00020181995.1 Gm54399 ENSMUST00020181995.1 Gm54399 (from geneSymbol) uc288woj.1 uc288woj.1 
ENSMUST00020181996.1 Gm55995 ENSMUST00020181996.1 Gm55995 (from geneSymbol) uc288wok.1 uc288wok.1 
ENSMUST00020181997.1 Gm54809 ENSMUST00020181997.1 Gm54809 (from geneSymbol) uc288wol.1 uc288wol.1 
ENSMUST00020181998.1 Gm54607 ENSMUST00020181998.1 Gm54607 (from geneSymbol) uc288wom.1 uc288wom.1 
ENSMUST00020181999.1 Gm56372 ENSMUST00020181999.1 Gm56372 (from geneSymbol) uc288won.1 uc288won.1 
ENSMUST00020182000.1 Gm55093 ENSMUST00020182000.1 Gm55093 (from geneSymbol) uc288woo.1 uc288woo.1 
ENSMUST00020182001.1 Gm54885 ENSMUST00020182001.1 Gm54885 (from geneSymbol) uc288wop.1 uc288wop.1 
ENSMUST00020182002.1 Gm55493 ENSMUST00020182002.1 Gm55493 (from geneSymbol) uc288woq.1 uc288woq.1 
ENSMUST00020182003.1 Gm55419 ENSMUST00020182003.1 Gm55419 (from geneSymbol) uc288wor.1 uc288wor.1 
ENSMUST00020182004.1 Gm25053 ENSMUST00020182004.1 Gm25053 (from geneSymbol) uc288wos.1 uc288wos.1 
ENSMUST00020182005.1 Gm55810 ENSMUST00020182005.1 Gm55810 (from geneSymbol) uc288wot.1 uc288wot.1 
ENSMUST00020182006.1 Gm55934 ENSMUST00020182006.1 Gm55934 (from geneSymbol) LF201090 uc288wou.1 uc288wou.1 
ENSMUST00020182007.1 Gm56078 ENSMUST00020182007.1 Gm56078 (from geneSymbol) uc288wov.1 uc288wov.1 
ENSMUST00020182008.1 Gm55932 ENSMUST00020182008.1 Gm55932 (from geneSymbol) uc288wow.1 uc288wow.1 
ENSMUST00020182009.1 Gm55094 ENSMUST00020182009.1 Gm55094 (from geneSymbol) uc288wox.1 uc288wox.1 
ENSMUST00020182010.1 Gm56419 ENSMUST00020182010.1 Gm56419 (from geneSymbol) uc288woy.1 uc288woy.1 
ENSMUST00020182011.1 Gm55769 ENSMUST00020182011.1 Gm55769 (from geneSymbol) uc288woz.1 uc288woz.1 
ENSMUST00020182012.1 Gm54590 ENSMUST00020182012.1 Gm54590 (from geneSymbol) uc288wpa.1 uc288wpa.1 
ENSMUST00020182013.1 Gm55624 ENSMUST00020182013.1 Gm55624 (from geneSymbol) AB352978 uc288wpb.1 uc288wpb.1 
ENSMUST00020182014.1 Gm55152 ENSMUST00020182014.1 Gm55152 (from geneSymbol) uc288wpc.1 uc288wpc.1 
ENSMUST00020182015.1 Gm55963 ENSMUST00020182015.1 Gm55963 (from geneSymbol) uc288wpd.1 uc288wpd.1 
ENSMUST00020182016.1 Gm56222 ENSMUST00020182016.1 Gm56222 (from geneSymbol) LF198948 uc288wpe.1 uc288wpe.1 
ENSMUST00020182017.1 Gm54460 ENSMUST00020182017.1 Gm54460 (from geneSymbol) uc288wpf.1 uc288wpf.1 
ENSMUST00020182018.1 Gm55077 ENSMUST00020182018.1 Gm55077 (from geneSymbol) uc288wpg.1 uc288wpg.1 
ENSMUST00020182019.1 Gm54943 ENSMUST00020182019.1 Gm54943 (from geneSymbol) LF201503 uc288wph.1 uc288wph.1 
ENSMUST00020182020.1 Gm54658 ENSMUST00020182020.1 Gm54658 (from geneSymbol) uc288wpi.1 uc288wpi.1 
ENSMUST00020182021.1 Gm54828 ENSMUST00020182021.1 Gm54828 (from geneSymbol) uc288wpj.1 uc288wpj.1 
ENSMUST00020182022.1 Gm55644 ENSMUST00020182022.1 Gm55644 (from geneSymbol) LF196609 uc288wpk.1 uc288wpk.1 
ENSMUST00020182023.1 Gm54762 ENSMUST00020182023.1 Gm54762 (from geneSymbol) LF197952 uc288wpl.1 uc288wpl.1 
ENSMUST00020182024.1 Gm55775 ENSMUST00020182024.1 Gm55775 (from geneSymbol) LF195796 uc288wpm.1 uc288wpm.1 
ENSMUST00020182025.1 Gm55581 ENSMUST00020182025.1 Gm55581 (from geneSymbol) uc288wpn.1 uc288wpn.1 
ENSMUST00020182027.1 Gm55109 ENSMUST00020182027.1 Gm55109 (from geneSymbol) LF199329 uc288wpp.1 uc288wpp.1 
ENSMUST00020182028.1 Gm54614 ENSMUST00020182028.1 Gm54614 (from geneSymbol) uc288wpq.1 uc288wpq.1 
ENSMUST00020182029.1 Gm54895 ENSMUST00020182029.1 Gm54895 (from geneSymbol) uc288wpr.1 uc288wpr.1 
ENSMUST00020182030.1 Gm55471 ENSMUST00020182030.1 Gm55471 (from geneSymbol) uc288wps.1 uc288wps.1 
ENSMUST00020182031.1 Gm56092 ENSMUST00020182031.1 Gm56092 (from geneSymbol) uc288wpt.1 uc288wpt.1 
ENSMUST00020182032.1 Gm55176 ENSMUST00020182032.1 Gm55176 (from geneSymbol) uc288wpu.1 uc288wpu.1 
ENSMUST00020182033.1 Gm55247 ENSMUST00020182033.1 Gm55247 (from geneSymbol) AB352279 uc288wpv.1 uc288wpv.1 
ENSMUST00020182034.1 Gm56235 ENSMUST00020182034.1 Gm56235 (from geneSymbol) uc288wpw.1 uc288wpw.1 
ENSMUST00020182035.1 Gm56422 ENSMUST00020182035.1 Gm56422 (from geneSymbol) uc288wpx.1 uc288wpx.1 
ENSMUST00020182036.1 Gm55927 ENSMUST00020182036.1 Gm55927 (from geneSymbol) uc288wpy.1 uc288wpy.1 
ENSMUST00020182037.1 Gm55104 ENSMUST00020182037.1 Gm55104 (from geneSymbol) uc288wpz.1 uc288wpz.1 
ENSMUST00020182038.1 Gm54988 ENSMUST00020182038.1 Gm54988 (from geneSymbol) LF194086 uc288wqa.1 uc288wqa.1 
ENSMUST00020182039.1 Gm56276 ENSMUST00020182039.1 Gm56276 (from geneSymbol) uc288wqb.1 uc288wqb.1 
ENSMUST00020182040.1 Gm54983 ENSMUST00020182040.1 Gm54983 (from geneSymbol) uc288wqc.1 uc288wqc.1 
ENSMUST00020182041.1 Gm55972 ENSMUST00020182041.1 Gm55972 (from geneSymbol) uc288wqd.1 uc288wqd.1 
ENSMUST00020182042.1 Gm56007 ENSMUST00020182042.1 Gm56007 (from geneSymbol) X13055 uc288wqe.1 uc288wqe.1 
ENSMUST00020182043.1 Gm55052 ENSMUST00020182043.1 Gm55052 (from geneSymbol) AK020838 uc288wqf.1 uc288wqf.1 
ENSMUST00020182044.1 Gm55431 ENSMUST00020182044.1 Gm55431 (from geneSymbol) uc288wqg.1 uc288wqg.1 
ENSMUST00020182045.1 Gm55234 ENSMUST00020182045.1 Gm55234 (from geneSymbol) uc288wqh.1 uc288wqh.1 
ENSMUST00020182046.1 Gm55731 ENSMUST00020182046.1 Gm55731 (from geneSymbol) uc288wqi.1 uc288wqi.1 
ENSMUST00020182047.1 Gm55737 ENSMUST00020182047.1 Gm55737 (from geneSymbol) uc288wqj.1 uc288wqj.1 
ENSMUST00020182048.1 Gm54993 ENSMUST00020182048.1 Gm54993 (from geneSymbol) uc288wqk.1 uc288wqk.1 
ENSMUST00020182049.1 Gm54730 ENSMUST00020182049.1 Gm54730 (from geneSymbol) LF198182 uc288wql.1 uc288wql.1 
ENSMUST00020182050.1 Gm56034 ENSMUST00020182050.1 Gm56034 (from geneSymbol) uc288wqm.1 uc288wqm.1 
ENSMUST00020182051.1 Gm56138 ENSMUST00020182051.1 Gm56138 (from geneSymbol) uc288wqn.1 uc288wqn.1 
ENSMUST00020182052.1 Gm55870 ENSMUST00020182052.1 Gm55870 (from geneSymbol) LF250088 uc288wqo.1 uc288wqo.1 
ENSMUST00020182053.1 Gm54576 ENSMUST00020182053.1 Gm54576 (from geneSymbol) uc288wqp.1 uc288wqp.1 
ENSMUST00020182054.1 Gm55125 ENSMUST00020182054.1 Gm55125 (from geneSymbol) uc288wqq.1 uc288wqq.1 
ENSMUST00020182055.1 Gm54880 ENSMUST00020182055.1 Gm54880 (from geneSymbol) uc288wqr.1 uc288wqr.1 
ENSMUST00020182056.1 Gm55612 ENSMUST00020182056.1 Gm55612 (from geneSymbol) uc288wqs.1 uc288wqs.1 
ENSMUST00020182057.1 Gm54808 ENSMUST00020182057.1 Gm54808 (from geneSymbol) uc288wqt.1 uc288wqt.1 
ENSMUST00020182058.1 Gm56435 ENSMUST00020182058.1 Gm56435 (from geneSymbol) uc288wqu.1 uc288wqu.1 
ENSMUST00020182059.1 Gm56160 ENSMUST00020182059.1 Gm56160 (from geneSymbol) LF196185 uc288wqv.1 uc288wqv.1 
ENSMUST00020182060.1 Gm56399 ENSMUST00020182060.1 Gm56399 (from geneSymbol) uc288wqw.1 uc288wqw.1 
ENSMUST00020182061.1 Gm55705 ENSMUST00020182061.1 Gm55705 (from geneSymbol) uc288wqx.1 uc288wqx.1 
ENSMUST00020182062.1 Gm56395 ENSMUST00020182062.1 Gm56395 (from geneSymbol) uc288wqy.1 uc288wqy.1 
ENSMUST00020182063.1 Gm56228 ENSMUST00020182063.1 Gm56228 (from geneSymbol) uc288wqz.1 uc288wqz.1 
ENSMUST00020182064.1 Snora36b ENSMUST00020182064.1 small nucleolar RNA, H/ACA box 36B (from RefSeq NR_034044.1) NR_034044 uc288wra.1 uc288wra.1 
ENSMUST00020182065.1 Gm55470 ENSMUST00020182065.1 Gm55470 (from geneSymbol) uc288wrb.1 uc288wrb.1 
ENSMUST00020182066.1 Gm54919 ENSMUST00020182066.1 Gm54919 (from geneSymbol) uc288wrc.1 uc288wrc.1 
ENSMUST00020182067.1 Gm56297 ENSMUST00020182067.1 Gm56297 (from geneSymbol) uc288wrd.1 uc288wrd.1 
ENSMUST00020182068.1 Gm54875 ENSMUST00020182068.1 Gm54875 (from geneSymbol) AB350056 uc288wre.1 uc288wre.1 
ENSMUST00020182069.1 Gm55084 ENSMUST00020182069.1 Gm55084 (from geneSymbol) uc288wrf.1 uc288wrf.1 
ENSMUST00020182070.1 Gm54800 ENSMUST00020182070.1 Gm54800 (from geneSymbol) uc288wrg.1 uc288wrg.1 
ENSMUST00020182071.1 Gm55114 ENSMUST00020182071.1 Gm55114 (from geneSymbol) uc288wrh.1 uc288wrh.1 
ENSMUST00020182072.1 Gm54735 ENSMUST00020182072.1 Gm54735 (from geneSymbol) uc288wri.1 uc288wri.1 
ENSMUST00020182073.1 Gm54689 ENSMUST00020182073.1 Gm54689 (from geneSymbol) uc288wrj.1 uc288wrj.1 
ENSMUST00020182074.1 Gm54704 ENSMUST00020182074.1 Gm54704 (from geneSymbol) DQ311494 uc288wrk.1 uc288wrk.1 
ENSMUST00020182075.1 Gm55843 ENSMUST00020182075.1 Gm55843 (from geneSymbol) uc288wrl.1 uc288wrl.1 
ENSMUST00020182076.1 Gm55996 ENSMUST00020182076.1 Gm55996 (from geneSymbol) uc288wrm.1 uc288wrm.1 
ENSMUST00020182077.1 Gm55521 ENSMUST00020182077.1 Gm55521 (from geneSymbol) AK020483 uc288wrn.1 uc288wrn.1 
ENSMUST00020182078.1 Gm56387 ENSMUST00020182078.1 Gm56387 (from geneSymbol) uc288wro.1 uc288wro.1 
ENSMUST00020182079.1 Gm56386 ENSMUST00020182079.1 Gm56386 (from geneSymbol) uc288wrp.1 uc288wrp.1 
ENSMUST00020182080.1 Gm54533 ENSMUST00020182080.1 Gm54533 (from geneSymbol) uc288wrq.1 uc288wrq.1 
ENSMUST00020182081.1 Gm55623 ENSMUST00020182081.1 Gm55623 (from geneSymbol) uc288wrr.1 uc288wrr.1 
ENSMUST00020182082.1 Gm56442 ENSMUST00020182082.1 Gm56442 (from geneSymbol) AB351420 uc288wrs.1 uc288wrs.1 
ENSMUST00020182083.1 Gm56271 ENSMUST00020182083.1 Gm56271 (from geneSymbol) LF194371 uc288wrt.1 uc288wrt.1 
ENSMUST00020182084.1 Gm54617 ENSMUST00020182084.1 Gm54617 (from geneSymbol) uc288wru.1 uc288wru.1 
ENSMUST00020182085.1 Gm54806 ENSMUST00020182085.1 Gm54806 (from geneSymbol) uc288wrv.1 uc288wrv.1 
ENSMUST00020182086.1 Gm54715 ENSMUST00020182086.1 Gm54715 (from geneSymbol) DQ541194 uc288wrw.1 uc288wrw.1 
ENSMUST00020182087.1 Gm55301 ENSMUST00020182087.1 Gm55301 (from geneSymbol) uc288wrx.1 uc288wrx.1 
ENSMUST00020182088.1 Gm56484 ENSMUST00020182088.1 Gm56484 (from geneSymbol) uc288wry.1 uc288wry.1 
ENSMUST00020182089.1 Gm56345 ENSMUST00020182089.1 Gm56345 (from geneSymbol) uc288wrz.1 uc288wrz.1 
ENSMUST00020182090.1 Gm54797 ENSMUST00020182090.1 Gm54797 (from geneSymbol) uc288wsa.1 uc288wsa.1 
ENSMUST00020182091.1 Gm55030 ENSMUST00020182091.1 Gm55030 (from geneSymbol) uc288wsb.1 uc288wsb.1 
ENSMUST00020182092.1 Gm54872 ENSMUST00020182092.1 Gm54872 (from geneSymbol) uc288wsc.1 uc288wsc.1 
ENSMUST00020182093.1 Gm55537 ENSMUST00020182093.1 Gm55537 (from geneSymbol) uc288wsd.1 uc288wsd.1 
ENSMUST00020182094.1 Gm56038 ENSMUST00020182094.1 Gm56038 (from geneSymbol) uc288wse.1 uc288wse.1 
ENSMUST00020182095.1 Gm55957 ENSMUST00020182095.1 Gm55957 (from geneSymbol) uc288wsf.1 uc288wsf.1 
ENSMUST00020182096.1 Gm55233 ENSMUST00020182096.1 Gm55233 (from geneSymbol) uc288wsg.1 uc288wsg.1 
ENSMUST00020182097.1 Gm54563 ENSMUST00020182097.1 Gm54563 (from geneSymbol) DQ541194 uc288wsh.1 uc288wsh.1 
ENSMUST00020182098.1 Gm56202 ENSMUST00020182098.1 Gm56202 (from geneSymbol) uc288wsi.1 uc288wsi.1 
ENSMUST00020182099.1 Gm55653 ENSMUST00020182099.1 Gm55653 (from geneSymbol) uc288wsj.1 uc288wsj.1 
ENSMUST00020182100.1 Gm54794 ENSMUST00020182100.1 Gm54794 (from geneSymbol) uc288wsk.1 uc288wsk.1 
ENSMUST00020182101.1 Gm55291 ENSMUST00020182101.1 Gm55291 (from geneSymbol) uc288wsl.1 uc288wsl.1 
ENSMUST00020182102.1 Gm55298 ENSMUST00020182102.1 Gm55298 (from geneSymbol) uc288wsm.1 uc288wsm.1 
ENSMUST00020182103.1 Gm56196 ENSMUST00020182103.1 Gm56196 (from geneSymbol) uc288wsn.1 uc288wsn.1 
ENSMUST00020182104.1 Gm55575 ENSMUST00020182104.1 Gm55575 (from geneSymbol) uc288wso.1 uc288wso.1 
ENSMUST00020182105.1 Gm56113 ENSMUST00020182105.1 Gm56113 (from geneSymbol) uc288wsp.1 uc288wsp.1 
ENSMUST00020182106.1 Gm54772 ENSMUST00020182106.1 Gm54772 (from geneSymbol) uc288wsq.1 uc288wsq.1 
ENSMUST00020182107.1 Gm55177 ENSMUST00020182107.1 Gm55177 (from geneSymbol) uc288wsr.1 uc288wsr.1 
ENSMUST00020182108.1 Gm55861 ENSMUST00020182108.1 Gm55861 (from geneSymbol) uc288wss.1 uc288wss.1 
ENSMUST00020182109.1 Gm54770 ENSMUST00020182109.1 Gm54770 (from geneSymbol) uc288wst.1 uc288wst.1 
ENSMUST00020182110.1 Gm54936 ENSMUST00020182110.1 Gm54936 (from geneSymbol) uc288wsu.1 uc288wsu.1 
ENSMUST00020182111.1 Gm54559 ENSMUST00020182111.1 Gm54559 (from geneSymbol) DQ541194 uc288wsv.1 uc288wsv.1 
ENSMUST00020182112.1 Gm55913 ENSMUST00020182112.1 Gm55913 (from geneSymbol) uc288wsw.1 uc288wsw.1 
ENSMUST00020182113.1 Gm56204 ENSMUST00020182113.1 Gm56204 (from geneSymbol) uc288wsx.1 uc288wsx.1 
ENSMUST00020182114.1 Gm54964 ENSMUST00020182114.1 Gm54964 (from geneSymbol) uc288wsy.1 uc288wsy.1 
ENSMUST00020182115.1 Gm55387 ENSMUST00020182115.1 Gm55387 (from geneSymbol) uc288wsz.1 uc288wsz.1 
ENSMUST00020182116.1 Gm54783 ENSMUST00020182116.1 Gm54783 (from geneSymbol) uc288wta.1 uc288wta.1 
ENSMUST00020182117.1 Gm54504 ENSMUST00020182117.1 Gm54504 (from geneSymbol) uc288wtb.1 uc288wtb.1 
ENSMUST00020182118.1 Gm56174 ENSMUST00020182118.1 Gm56174 (from geneSymbol) uc288wtc.1 uc288wtc.1 
ENSMUST00020182119.1 Gm56316 ENSMUST00020182119.1 Gm56316 (from geneSymbol) uc288wtd.1 uc288wtd.1 
ENSMUST00020182120.1 Gm56424 ENSMUST00020182120.1 Gm56424 (from geneSymbol) uc288wte.1 uc288wte.1 
ENSMUST00020182121.1 Gm54506 ENSMUST00020182121.1 Gm54506 (from geneSymbol) uc288wtf.1 uc288wtf.1 
ENSMUST00020182122.1 Gm55588 ENSMUST00020182122.1 Gm55588 (from geneSymbol) LF192543 uc288wtg.1 uc288wtg.1 
ENSMUST00020182123.1 Gm55601 ENSMUST00020182123.1 Gm55601 (from geneSymbol) uc288wth.1 uc288wth.1 
ENSMUST00020182124.1 Gm54752 ENSMUST00020182124.1 Gm54752 (from geneSymbol) AB352500 uc288wti.1 uc288wti.1 
ENSMUST00020182125.1 Gm55336 ENSMUST00020182125.1 Gm55336 (from geneSymbol) uc288wtj.1 uc288wtj.1 
ENSMUST00020182126.1 Gm55924 ENSMUST00020182126.1 Gm55924 (from geneSymbol) uc288wtk.1 uc288wtk.1 
ENSMUST00020182127.1 Gm23786 ENSMUST00020182127.1 Gm23786 (from geneSymbol) uc288wtl.1 uc288wtl.1 
ENSMUST00020182128.1 Gm55709 ENSMUST00020182128.1 Gm55709 (from geneSymbol) uc288wtm.1 uc288wtm.1 
ENSMUST00020182129.1 Gm55509 ENSMUST00020182129.1 Gm55509 (from geneSymbol) uc288wtn.1 uc288wtn.1 
ENSMUST00020182130.1 Gm56209 ENSMUST00020182130.1 Gm56209 (from geneSymbol) uc288wto.1 uc288wto.1 
ENSMUST00020182131.1 Gm55009 ENSMUST00020182131.1 Gm55009 (from geneSymbol) uc288wtp.1 uc288wtp.1 
ENSMUST00020182132.1 Gm55311 ENSMUST00020182132.1 Gm55311 (from geneSymbol) AB352282 uc288wtq.1 uc288wtq.1 
ENSMUST00020182133.1 Gm54456 ENSMUST00020182133.1 Gm54456 (from geneSymbol) uc288wtr.1 uc288wtr.1 
ENSMUST00020182134.1 Gm56317 ENSMUST00020182134.1 Gm56317 (from geneSymbol) uc288wts.1 uc288wts.1 
ENSMUST00020182135.1 Gm56400 ENSMUST00020182135.1 Gm56400 (from geneSymbol) uc288wtt.1 uc288wtt.1 
ENSMUST00020182136.1 Snora16a ENSMUST00020182136.1 Snora16a (from geneSymbol) FM991911 uc288wtu.1 uc288wtu.1 
ENSMUST00020182137.1 Gm55956 ENSMUST00020182137.1 Gm55956 (from geneSymbol) uc288wtv.1 uc288wtv.1 
ENSMUST00020182138.1 Gm56145 ENSMUST00020182138.1 Gm56145 (from geneSymbol) LF193720 uc288wtw.1 uc288wtw.1 
ENSMUST00020182139.1 Gm54879 ENSMUST00020182139.1 Gm54879 (from geneSymbol) uc288wtx.1 uc288wtx.1 
ENSMUST00020182140.1 Gm55604 ENSMUST00020182140.1 Gm55604 (from geneSymbol) uc288wty.1 uc288wty.1 
ENSMUST00020182141.1 Gm55099 ENSMUST00020182141.1 Gm55099 (from geneSymbol) AB352282 uc288wtz.1 uc288wtz.1 
ENSMUST00020182142.1 Gm55620 ENSMUST00020182142.1 Gm55620 (from geneSymbol) uc288wua.1 uc288wua.1 
ENSMUST00020182143.1 Gm54830 ENSMUST00020182143.1 Gm54830 (from geneSymbol) uc288wub.1 uc288wub.1 
ENSMUST00020182144.1 Gm54564 ENSMUST00020182144.1 Gm54564 (from geneSymbol) uc288wuc.1 uc288wuc.1 
ENSMUST00020182145.1 Gm55615 ENSMUST00020182145.1 Gm55615 (from geneSymbol) uc288wud.1 uc288wud.1 
ENSMUST00020182146.1 Gm56105 ENSMUST00020182146.1 Gm56105 (from geneSymbol) uc288wue.1 uc288wue.1 
ENSMUST00020182147.1 Gm55513 ENSMUST00020182147.1 Gm55513 (from geneSymbol) uc288wuf.1 uc288wuf.1 
ENSMUST00020182148.1 Gm55686 ENSMUST00020182148.1 Gm55686 (from geneSymbol) uc288wug.1 uc288wug.1 
ENSMUST00020182149.1 Gm55335 ENSMUST00020182149.1 Gm55335 (from geneSymbol) uc288wuh.1 uc288wuh.1 
ENSMUST00020182150.1 Gm55561 ENSMUST00020182150.1 Gm55561 (from geneSymbol) AB352978 uc288wui.1 uc288wui.1 
ENSMUST00020182151.1 Gm55787 ENSMUST00020182151.1 Gm55787 (from geneSymbol) uc288wuj.1 uc288wuj.1 
ENSMUST00020182152.1 Gm54769 ENSMUST00020182152.1 Gm54769 (from geneSymbol) uc288wuk.1 uc288wuk.1 
ENSMUST00020182153.1 Gm55532 ENSMUST00020182153.1 Gm55532 (from geneSymbol) uc288wul.1 uc288wul.1 
ENSMUST00020182154.1 Gm55251 ENSMUST00020182154.1 Gm55251 (from geneSymbol) uc288wum.1 uc288wum.1 
ENSMUST00020182155.1 Gm55014 ENSMUST00020182155.1 Gm55014 (from geneSymbol) DQ311494 uc288wun.1 uc288wun.1 
ENSMUST00020182156.1 Gm54510 ENSMUST00020182156.1 Gm54510 (from geneSymbol) uc288wuo.1 uc288wuo.1 
ENSMUST00020182157.1 Gm55720 ENSMUST00020182157.1 Gm55720 (from geneSymbol) uc288wup.1 uc288wup.1 
ENSMUST00020182158.1 Gm55075 ENSMUST00020182158.1 Gm55075 (from geneSymbol) uc288wuq.1 uc288wuq.1 
ENSMUST00020182159.1 Gm55672 ENSMUST00020182159.1 Gm55672 (from geneSymbol) uc288wur.1 uc288wur.1 
ENSMUST00020182160.1 Gm55025 ENSMUST00020182160.1 Gm55025 (from geneSymbol) LF198267 uc288wus.1 uc288wus.1 
ENSMUST00020182161.1 Gm54995 ENSMUST00020182161.1 Gm54995 (from geneSymbol) LF262441 uc288wut.1 uc288wut.1 
ENSMUST00020182162.1 Gm55563 ENSMUST00020182162.1 Gm55563 (from geneSymbol) uc288wuu.1 uc288wuu.1 
ENSMUST00020182163.1 Gm54573 ENSMUST00020182163.1 Gm54573 (from geneSymbol) uc288wuv.1 uc288wuv.1 
ENSMUST00020182164.1 Gm54424 ENSMUST00020182164.1 Gm54424 (from geneSymbol) uc288wuw.1 uc288wuw.1 
ENSMUST00020182165.1 Gm54482 ENSMUST00020182165.1 Gm54482 (from geneSymbol) uc288wux.1 uc288wux.1 
ENSMUST00020182166.1 Gm55696 ENSMUST00020182166.1 Gm55696 (from geneSymbol) uc288wuy.1 uc288wuy.1 
ENSMUST00020182167.1 Gm54962 ENSMUST00020182167.1 Gm54962 (from geneSymbol) uc288wuz.1 uc288wuz.1 
ENSMUST00020182168.1 Gm54814 ENSMUST00020182168.1 Gm54814 (from geneSymbol) uc288wva.1 uc288wva.1 
ENSMUST00020182169.1 Gm56068 ENSMUST00020182169.1 Gm56068 (from geneSymbol) uc288wvb.1 uc288wvb.1 
ENSMUST00020182170.1 Gm56090 ENSMUST00020182170.1 Gm56090 (from geneSymbol) uc288wvc.1 uc288wvc.1 
ENSMUST00020182171.1 Gm54472 ENSMUST00020182171.1 Gm54472 (from geneSymbol) uc288wvd.1 uc288wvd.1 
ENSMUST00020182172.1 Gm56107 ENSMUST00020182172.1 Gm56107 (from geneSymbol) uc288wve.1 uc288wve.1 
ENSMUST00020182173.1 Gm54579 ENSMUST00020182173.1 Gm54579 (from geneSymbol) uc288wvf.1 uc288wvf.1 
ENSMUST00020182174.1 Gm55864 ENSMUST00020182174.1 Gm55864 (from geneSymbol) LF198018 uc288wvg.1 uc288wvg.1 
ENSMUST00020182175.1 Gm56291 ENSMUST00020182175.1 Gm56291 (from geneSymbol) uc288wvh.1 uc288wvh.1 
ENSMUST00020182176.1 Gm54369 ENSMUST00020182176.1 Gm54369 (from geneSymbol) LF199333 uc288wvi.1 uc288wvi.1 
ENSMUST00020182177.1 Gm55530 ENSMUST00020182177.1 Gm55530 (from geneSymbol) uc288wvj.1 uc288wvj.1 
ENSMUST00020182178.1 Gm55308 ENSMUST00020182178.1 Gm55308 (from geneSymbol) uc288wvk.1 uc288wvk.1 
ENSMUST00020182179.1 Gm55796 ENSMUST00020182179.1 Gm55796 (from geneSymbol) DQ311494 uc288wvl.1 uc288wvl.1 
ENSMUST00020182180.1 Gm55987 ENSMUST00020182180.1 Gm55987 (from geneSymbol) uc288wvm.1 uc288wvm.1 
ENSMUST00020182181.1 Gm54938 ENSMUST00020182181.1 Gm54938 (from geneSymbol) uc288wvn.1 uc288wvn.1 
ENSMUST00020182182.1 Gm55394 ENSMUST00020182182.1 Gm55394 (from geneSymbol) uc288wvo.1 uc288wvo.1 
ENSMUST00020182183.1 Gm54821 ENSMUST00020182183.1 Gm54821 (from geneSymbol) AB352978 uc288wvp.1 uc288wvp.1 
ENSMUST00020182184.1 Gm56355 ENSMUST00020182184.1 Gm56355 (from geneSymbol) AB352978 uc288wvq.1 uc288wvq.1 
ENSMUST00020182185.1 Gm54707 ENSMUST00020182185.1 Gm54707 (from geneSymbol) uc288wvr.1 uc288wvr.1 
ENSMUST00020182186.1 Gm55868 ENSMUST00020182186.1 Gm55868 (from geneSymbol) uc288wvs.1 uc288wvs.1 
ENSMUST00020182187.1 Gm54361 ENSMUST00020182187.1 Gm54361 (from geneSymbol) uc288wvt.1 uc288wvt.1 
ENSMUST00020182188.1 Gm54402 ENSMUST00020182188.1 Gm54402 (from geneSymbol) uc288wvu.1 uc288wvu.1 
ENSMUST00020182189.1 Gm56095 ENSMUST00020182189.1 Gm56095 (from geneSymbol) uc288wvv.1 uc288wvv.1 
ENSMUST00020182190.1 Gm55279 ENSMUST00020182190.1 Gm55279 (from geneSymbol) uc288wvw.1 uc288wvw.1 
ENSMUST00020182191.1 Gm54339 ENSMUST00020182191.1 Gm54339 (from geneSymbol) uc288wvx.1 uc288wvx.1 
ENSMUST00020182192.1 Gm56356 ENSMUST00020182192.1 Gm56356 (from geneSymbol) uc288wvy.1 uc288wvy.1 
ENSMUST00020182193.1 Gm54418 ENSMUST00020182193.1 Gm54418 (from geneSymbol) AB352500 uc288wvz.1 uc288wvz.1 
ENSMUST00020182194.1 Gm54574 ENSMUST00020182194.1 Gm54574 (from geneSymbol) uc288wwa.1 uc288wwa.1 
ENSMUST00020182195.1 Gm55240 ENSMUST00020182195.1 Gm55240 (from geneSymbol) AB351420 uc288wwb.1 uc288wwb.1 
ENSMUST00020182196.1 Gm54415 ENSMUST00020182196.1 Gm54415 (from geneSymbol) uc288wwc.1 uc288wwc.1 
ENSMUST00020182197.1 Gm54746 ENSMUST00020182197.1 Gm54746 (from geneSymbol) uc288wwd.1 uc288wwd.1 
ENSMUST00020182198.1 Gm55664 ENSMUST00020182198.1 Gm55664 (from geneSymbol) uc288wwe.1 uc288wwe.1 
ENSMUST00020182199.1 Gm55194 ENSMUST00020182199.1 Gm55194 (from geneSymbol) uc288wwf.1 uc288wwf.1 
ENSMUST00020182200.1 Gm55878 ENSMUST00020182200.1 Gm55878 (from geneSymbol) uc288wwg.1 uc288wwg.1 
ENSMUST00020182201.1 Gm54634 ENSMUST00020182201.1 Gm54634 (from geneSymbol) uc288wwh.1 uc288wwh.1 
ENSMUST00020182202.1 Gm54610 ENSMUST00020182202.1 Gm54610 (from geneSymbol) DQ540915 uc288wwi.1 uc288wwi.1 
ENSMUST00020182203.1 Gm55732 ENSMUST00020182203.1 Gm55732 (from geneSymbol) uc288wwj.1 uc288wwj.1 
ENSMUST00020182204.1 Gm56436 ENSMUST00020182204.1 Gm56436 (from geneSymbol) uc288wwk.1 uc288wwk.1 
ENSMUST00020182205.1 Gm55448 ENSMUST00020182205.1 Gm55448 (from geneSymbol) uc288wwl.1 uc288wwl.1 
ENSMUST00020182206.1 Gm55243 ENSMUST00020182206.1 Gm55243 (from geneSymbol) uc288wwm.1 uc288wwm.1 
ENSMUST00020182207.1 Gm55661 ENSMUST00020182207.1 Gm55661 (from geneSymbol) uc288wwn.1 uc288wwn.1 
ENSMUST00020182208.1 Gm55397 ENSMUST00020182208.1 Gm55397 (from geneSymbol) AK143156 uc288wwo.1 uc288wwo.1 
ENSMUST00020182209.1 Gm56336 ENSMUST00020182209.1 Gm56336 (from geneSymbol) DQ311494 uc288wwp.1 uc288wwp.1 
ENSMUST00020182210.1 Gm55844 ENSMUST00020182210.1 Gm55844 (from geneSymbol) uc288wwq.1 uc288wwq.1 
ENSMUST00020182211.1 Gm56315 ENSMUST00020182211.1 Gm56315 (from geneSymbol) uc288wwr.1 uc288wwr.1 
ENSMUST00020182212.1 Gm55794 ENSMUST00020182212.1 Gm55794 (from geneSymbol) uc288wws.1 uc288wws.1 
ENSMUST00020182213.1 Gm56139 ENSMUST00020182213.1 Gm56139 (from geneSymbol) uc288wwt.1 uc288wwt.1 
ENSMUST00020182214.1 Gm56447 ENSMUST00020182214.1 Gm56447 (from geneSymbol) uc288wwu.1 uc288wwu.1 
ENSMUST00020182215.1 Gm55263 ENSMUST00020182215.1 Gm55263 (from geneSymbol) uc288wwv.1 uc288wwv.1 
ENSMUST00020182216.1 Gm55427 ENSMUST00020182216.1 Gm55427 (from geneSymbol) uc288www.1 uc288www.1 
ENSMUST00020182217.1 Gm56440 ENSMUST00020182217.1 Gm56440 (from geneSymbol) uc288wwx.1 uc288wwx.1 
ENSMUST00020182218.1 Gm56366 ENSMUST00020182218.1 Gm56366 (from geneSymbol) uc288wwy.1 uc288wwy.1 
ENSMUST00020182219.1 Gm55634 ENSMUST00020182219.1 Gm55634 (from geneSymbol) uc288wwz.1 uc288wwz.1 
ENSMUST00020182220.1 Gm55514 ENSMUST00020182220.1 Gm55514 (from geneSymbol) uc288wxa.1 uc288wxa.1 
ENSMUST00020182221.1 Gm55593 ENSMUST00020182221.1 Gm55593 (from geneSymbol) uc288wxb.1 uc288wxb.1 
ENSMUST00020182222.1 Gm54379 ENSMUST00020182222.1 Gm54379 (from geneSymbol) DQ311494 uc288wxc.1 uc288wxc.1 
ENSMUST00020182223.1 Gm55793 ENSMUST00020182223.1 Gm55793 (from geneSymbol) uc288wxd.1 uc288wxd.1 
ENSMUST00020182224.1 Gm54789 ENSMUST00020182224.1 Gm54789 (from geneSymbol) uc288wxe.1 uc288wxe.1 
ENSMUST00020182225.1 Gm55584 ENSMUST00020182225.1 Gm55584 (from geneSymbol) uc288wxf.1 uc288wxf.1 
ENSMUST00020182226.1 Gm54520 ENSMUST00020182226.1 Gm54520 (from geneSymbol) uc288wxg.1 uc288wxg.1 
ENSMUST00020182227.1 Gm54386 ENSMUST00020182227.1 Gm54386 (from geneSymbol) AB352500 uc288wxh.1 uc288wxh.1 
ENSMUST00020182228.1 Gm56340 ENSMUST00020182228.1 Gm56340 (from geneSymbol) uc288wxi.1 uc288wxi.1 
ENSMUST00020182229.1 Gm55486 ENSMUST00020182229.1 Gm55486 (from geneSymbol) uc288wxj.1 uc288wxj.1 
ENSMUST00020182230.1 Gm54683 ENSMUST00020182230.1 Gm54683 (from geneSymbol) uc288wxk.1 uc288wxk.1 
ENSMUST00020182231.1 Gm56151 ENSMUST00020182231.1 Gm56151 (from geneSymbol) uc288wxl.1 uc288wxl.1 
ENSMUST00020182232.1 Gm54888 ENSMUST00020182232.1 Gm54888 (from geneSymbol) uc288wxm.1 uc288wxm.1 
ENSMUST00020182233.1 Gm56281 ENSMUST00020182233.1 Gm56281 (from geneSymbol) uc288wxn.1 uc288wxn.1 
ENSMUST00020182234.1 Gm54496 ENSMUST00020182234.1 Gm54496 (from geneSymbol) uc288wxo.1 uc288wxo.1 
ENSMUST00020182235.1 Gm55725 ENSMUST00020182235.1 Gm55725 (from geneSymbol) uc288wxp.1 uc288wxp.1 
ENSMUST00020182236.1 Gm56398 ENSMUST00020182236.1 Gm56398 (from geneSymbol) uc288wxq.1 uc288wxq.1 
ENSMUST00020182237.1 Gm55462 ENSMUST00020182237.1 Gm55462 (from geneSymbol) uc288wxr.1 uc288wxr.1 
ENSMUST00020182238.1 ENSMUSG00002074970 ENSMUST00020182238.1 ENSMUSG00002074970 (from geneSymbol) AB351420 uc288wxs.1 uc288wxs.1 
ENSMUST00020182239.1 Gm55947 ENSMUST00020182239.1 Gm55947 (from geneSymbol) uc288wxt.1 uc288wxt.1 
ENSMUST00020182240.1 Gm55814 ENSMUST00020182240.1 Gm55814 (from geneSymbol) uc288wxu.1 uc288wxu.1 
ENSMUST00020182241.1 Gm55877 ENSMUST00020182241.1 Gm55877 (from geneSymbol) uc288wxv.1 uc288wxv.1 
ENSMUST00020182242.1 Gm54739 ENSMUST00020182242.1 Gm54739 (from geneSymbol) uc288wxw.1 uc288wxw.1 
ENSMUST00020182243.1 Gm56423 ENSMUST00020182243.1 Gm56423 (from geneSymbol) uc288wxx.1 uc288wxx.1 
ENSMUST00020182244.1 Gm54499 ENSMUST00020182244.1 Gm54499 (from geneSymbol) uc288wxy.1 uc288wxy.1 
ENSMUST00020182245.1 Gm55949 ENSMUST00020182245.1 Gm55949 (from geneSymbol) uc288wxz.1 uc288wxz.1 
ENSMUST00020182246.1 Gm56109 ENSMUST00020182246.1 Gm56109 (from geneSymbol) LF196290 uc288wya.1 uc288wya.1 
ENSMUST00020182247.1 Gm56205 ENSMUST00020182247.1 Gm56205 (from geneSymbol) uc288wyb.1 uc288wyb.1 
ENSMUST00020182248.1 Gm56165 ENSMUST00020182248.1 Gm56165 (from geneSymbol) uc288wyc.1 uc288wyc.1 
ENSMUST00020182249.1 Gm55750 ENSMUST00020182249.1 Gm55750 (from geneSymbol) uc288wyd.1 uc288wyd.1 
ENSMUST00020182250.1 Gm55262 ENSMUST00020182250.1 Gm55262 (from geneSymbol) uc288wye.1 uc288wye.1 
ENSMUST00020182251.1 Gm54705 ENSMUST00020182251.1 Gm54705 (from geneSymbol) DQ311494 uc288wyf.1 uc288wyf.1 
ENSMUST00020182252.1 Gm55807 ENSMUST00020182252.1 Gm55807 (from geneSymbol) uc288wyg.1 uc288wyg.1 
ENSMUST00020182253.1 Gm54956 ENSMUST00020182253.1 Gm54956 (from geneSymbol) uc288wyh.1 uc288wyh.1 
ENSMUST00020182254.1 Gm54659 ENSMUST00020182254.1 Gm54659 (from geneSymbol) uc288wyi.1 uc288wyi.1 
ENSMUST00020182255.1 Gm54527 ENSMUST00020182255.1 Gm54527 (from geneSymbol) uc288wyj.1 uc288wyj.1 
ENSMUST00020182256.1 Gm54581 ENSMUST00020182256.1 Gm54581 (from geneSymbol) uc288wyk.1 uc288wyk.1 
ENSMUST00020182257.1 Gm54842 ENSMUST00020182257.1 Gm54842 (from geneSymbol) AB351420 uc288wyl.1 uc288wyl.1 
ENSMUST00020182258.1 Gm56448 ENSMUST00020182258.1 Gm56448 (from geneSymbol) DQ311494 uc288wym.1 uc288wym.1 
ENSMUST00020182259.1 Gm55189 ENSMUST00020182259.1 Gm55189 (from geneSymbol) uc288wyn.1 uc288wyn.1 
ENSMUST00020182260.1 Gm55649 ENSMUST00020182260.1 Gm55649 (from geneSymbol) uc288wyo.1 uc288wyo.1 
ENSMUST00020182261.1 Gm55833 ENSMUST00020182261.1 Gm55833 (from geneSymbol) DQ311494 uc288wyp.1 uc288wyp.1 
ENSMUST00020182262.1 Gm56073 ENSMUST00020182262.1 Gm56073 (from geneSymbol) uc288wyq.1 uc288wyq.1 
ENSMUST00020182263.1 Gm55659 ENSMUST00020182263.1 Gm55659 (from geneSymbol) uc288wyr.1 uc288wyr.1 
ENSMUST00020182264.1 Gm56181 ENSMUST00020182264.1 Gm56181 (from geneSymbol) uc288wys.1 uc288wys.1 
ENSMUST00020182265.1 Gm54695 ENSMUST00020182265.1 Gm54695 (from geneSymbol) uc288wyt.1 uc288wyt.1 
ENSMUST00020182266.1 Gm54686 ENSMUST00020182266.1 Gm54686 (from geneSymbol) uc288wyu.1 uc288wyu.1 
ENSMUST00020182267.1 Gm56143 ENSMUST00020182267.1 Gm56143 (from geneSymbol) uc288wyv.1 uc288wyv.1 
ENSMUST00020182268.1 Gm56259 ENSMUST00020182268.1 Gm56259 (from geneSymbol) uc288wyw.1 uc288wyw.1 
ENSMUST00020182269.1 Gm55321 ENSMUST00020182269.1 Gm55321 (from geneSymbol) uc288wyx.1 uc288wyx.1 
ENSMUST00020182270.1 Gm55320 ENSMUST00020182270.1 Gm55320 (from geneSymbol) uc288wyy.1 uc288wyy.1 
ENSMUST00020182271.1 Gm54928 ENSMUST00020182271.1 Gm54928 (from geneSymbol) uc288wyz.1 uc288wyz.1 
ENSMUST00020182272.1 Gm56344 ENSMUST00020182272.1 Gm56344 (from geneSymbol) uc288wza.1 uc288wza.1 
ENSMUST00020182273.1 Gm54622 ENSMUST00020182273.1 Gm54622 (from geneSymbol) uc288wzb.1 uc288wzb.1 
ENSMUST00020182274.1 Gm54996 ENSMUST00020182274.1 Gm54996 (from geneSymbol) uc288wzc.1 uc288wzc.1 
ENSMUST00020182275.1 Gm54682 ENSMUST00020182275.1 Gm54682 (from geneSymbol) uc288wzd.1 uc288wzd.1 
ENSMUST00020182276.1 Gm55418 ENSMUST00020182276.1 Gm55418 (from geneSymbol) uc288wze.1 uc288wze.1 
ENSMUST00020182277.1 Gm55607 ENSMUST00020182277.1 Gm55607 (from geneSymbol) uc288wzf.1 uc288wzf.1 
ENSMUST00020182278.1 Gm54382 ENSMUST00020182278.1 Gm54382 (from geneSymbol) uc288wzg.1 uc288wzg.1 
ENSMUST00020182279.1 Gm55811 ENSMUST00020182279.1 Gm55811 (from geneSymbol) uc288wzh.1 uc288wzh.1 
ENSMUST00020182280.1 Gm54438 ENSMUST00020182280.1 Gm54438 (from geneSymbol) uc288wzi.1 uc288wzi.1 
ENSMUST00020182281.1 Gm54700 ENSMUST00020182281.1 Gm54700 (from geneSymbol) uc288wzj.1 uc288wzj.1 
ENSMUST00020182282.1 Gm56124 ENSMUST00020182282.1 Gm56124 (from geneSymbol) uc288wzk.1 uc288wzk.1 
ENSMUST00020182283.1 Gm55016 ENSMUST00020182283.1 Gm55016 (from geneSymbol) uc288wzl.1 uc288wzl.1 
ENSMUST00020182284.1 Snord100 ENSMUST00020182284.1 small nucleolar RNA, C/D box 100 (from RefSeq NR_037681.2) NR_037681 uc288wzm.1 uc288wzm.1 
ENSMUST00020182285.1 Gm55198 ENSMUST00020182285.1 Gm55198 (from geneSymbol) uc288wzn.1 uc288wzn.1 
ENSMUST00020182286.1 Gm56275 ENSMUST00020182286.1 Gm56275 (from geneSymbol) LF192550 uc288wzo.1 uc288wzo.1 
ENSMUST00020182287.1 Gm55500 ENSMUST00020182287.1 Gm55500 (from geneSymbol) uc288wzp.1 uc288wzp.1 
ENSMUST00020182288.1 Gm54780 ENSMUST00020182288.1 Gm54780 (from geneSymbol) LF200227 uc288wzq.1 uc288wzq.1 
ENSMUST00020182289.1 Gm56019 ENSMUST00020182289.1 Gm56019 (from geneSymbol) uc288wzr.1 uc288wzr.1 
ENSMUST00020182290.1 Gm54628 ENSMUST00020182290.1 Gm54628 (from geneSymbol) uc288wzs.1 uc288wzs.1 
ENSMUST00020182291.1 Gm55426 ENSMUST00020182291.1 Gm55426 (from geneSymbol) uc288wzt.1 uc288wzt.1 
ENSMUST00020182292.1 Gm54417 ENSMUST00020182292.1 Gm54417 (from geneSymbol) uc288wzu.1 uc288wzu.1 
ENSMUST00020182293.1 Gm55204 ENSMUST00020182293.1 Gm55204 (from geneSymbol) uc288wzv.1 uc288wzv.1 
ENSMUST00020182294.1 Gm54640 ENSMUST00020182294.1 Gm54640 (from geneSymbol) uc288wzw.1 uc288wzw.1 
ENSMUST00020182295.1 Gm56003 ENSMUST00020182295.1 Gm56003 (from geneSymbol) LF195838 uc288wzx.1 uc288wzx.1 
ENSMUST00020182296.1 Gm56134 ENSMUST00020182296.1 Gm56134 (from geneSymbol) uc288wzy.1 uc288wzy.1 
ENSMUST00020182297.1 Gm55340 ENSMUST00020182297.1 Gm55340 (from geneSymbol) uc288wzz.1 uc288wzz.1 
ENSMUST00020182298.1 Gm55758 ENSMUST00020182298.1 Gm55758 (from geneSymbol) uc288xaa.1 uc288xaa.1 
ENSMUST00020182299.1 Gm56111 ENSMUST00020182299.1 Gm56111 (from geneSymbol) uc288xab.1 uc288xab.1 
ENSMUST00020182300.1 Gm56413 ENSMUST00020182300.1 Gm56413 (from geneSymbol) uc288xac.1 uc288xac.1 
ENSMUST00020182301.1 Gm56293 ENSMUST00020182301.1 Gm56293 (from geneSymbol) uc288xad.1 uc288xad.1 
ENSMUST00020182302.1 Gm56253 ENSMUST00020182302.1 Gm56253 (from geneSymbol) uc288xae.1 uc288xae.1 
ENSMUST00020182303.1 Gm55149 ENSMUST00020182303.1 Gm55149 (from geneSymbol) LF262441 uc288xaf.1 uc288xaf.1 
ENSMUST00020182304.1 Gm55745 ENSMUST00020182304.1 Gm55745 (from geneSymbol) uc288xag.1 uc288xag.1 
ENSMUST00020182305.1 Gm54839 ENSMUST00020182305.1 Gm54839 (from geneSymbol) uc288xah.1 uc288xah.1 
ENSMUST00020182306.1 Gm55688 ENSMUST00020182306.1 Gm55688 (from geneSymbol) uc288xai.1 uc288xai.1 
ENSMUST00020182307.1 Gm56206 ENSMUST00020182307.1 Gm56206 (from geneSymbol) uc288xaj.1 uc288xaj.1 
ENSMUST00020182308.1 Gm54716 ENSMUST00020182308.1 Gm54716 (from geneSymbol) uc288xak.1 uc288xak.1 
ENSMUST00020182309.1 Gm56081 ENSMUST00020182309.1 Gm56081 (from geneSymbol) LF192510 uc288xal.1 uc288xal.1 
ENSMUST00020182310.1 Gm55275 ENSMUST00020182310.1 Gm55275 (from geneSymbol) uc288xam.1 uc288xam.1 
ENSMUST00020182311.1 Gm55799 ENSMUST00020182311.1 Gm55799 (from geneSymbol) uc288xan.1 uc288xan.1 
ENSMUST00020182312.1 Gm55373 ENSMUST00020182312.1 Gm55373 (from geneSymbol) uc288xao.1 uc288xao.1 
ENSMUST00020182313.1 Gm56011 ENSMUST00020182313.1 Gm56011 (from geneSymbol) uc288xap.1 uc288xap.1 
ENSMUST00020182314.1 Gm55124 ENSMUST00020182314.1 Gm55124 (from geneSymbol) uc288xaq.1 uc288xaq.1 
ENSMUST00020182315.1 Gm54733 ENSMUST00020182315.1 Gm54733 (from geneSymbol) uc288xar.1 uc288xar.1 
ENSMUST00020182316.1 Gm54384 ENSMUST00020182316.1 Gm54384 (from geneSymbol) uc288xas.1 uc288xas.1 
ENSMUST00020182317.1 Gm56149 ENSMUST00020182317.1 Gm56149 (from geneSymbol) AB352500 uc288xat.1 uc288xat.1 
ENSMUST00020182318.1 Gm54374 ENSMUST00020182318.1 Gm54374 (from geneSymbol) uc288xau.1 uc288xau.1 
ENSMUST00020182319.1 Gm54572 ENSMUST00020182319.1 Gm54572 (from geneSymbol) uc288xav.1 uc288xav.1 
ENSMUST00020182320.1 Gm54711 ENSMUST00020182320.1 Gm54711 (from geneSymbol) uc288xaw.1 uc288xaw.1 
ENSMUST00020182321.1 Gm56088 ENSMUST00020182321.1 Gm56088 (from geneSymbol) uc288xax.1 uc288xax.1 
ENSMUST00020182322.1 Gm55157 ENSMUST00020182322.1 Gm55157 (from geneSymbol) uc288xay.1 uc288xay.1 
ENSMUST00020182323.1 Gm54578 ENSMUST00020182323.1 Gm54578 (from geneSymbol) uc288xaz.1 uc288xaz.1 
ENSMUST00020182324.1 Gm54368 ENSMUST00020182324.1 Gm54368 (from geneSymbol) uc288xba.1 uc288xba.1 
ENSMUST00020182325.1 Gm56321 ENSMUST00020182325.1 Gm56321 (from geneSymbol) uc288xbb.1 uc288xbb.1 
ENSMUST00020182326.1 Gm55678 ENSMUST00020182326.1 Gm55678 (from geneSymbol) uc288xbc.1 uc288xbc.1 
ENSMUST00020182327.1 Gm54921 ENSMUST00020182327.1 Gm54921 (from geneSymbol) AB352500 uc288xbd.1 uc288xbd.1 
ENSMUST00020182328.1 Gm54619 ENSMUST00020182328.1 Gm54619 (from geneSymbol) uc288xbe.1 uc288xbe.1 
ENSMUST00020182329.1 Gm56135 ENSMUST00020182329.1 Gm56135 (from geneSymbol) uc288xbf.1 uc288xbf.1 
ENSMUST00020182330.1 Gm55599 ENSMUST00020182330.1 Gm55599 (from geneSymbol) uc288xbg.1 uc288xbg.1 
ENSMUST00020182331.1 Gm54912 ENSMUST00020182331.1 Gm54912 (from geneSymbol) uc288xbh.1 uc288xbh.1 
ENSMUST00020182332.1 Gm55248 ENSMUST00020182332.1 Gm55248 (from geneSymbol) uc288xbi.1 uc288xbi.1 
ENSMUST00020182333.1 Gm54602 ENSMUST00020182333.1 Gm54602 (from geneSymbol) uc288xbj.1 uc288xbj.1 
ENSMUST00020182334.1 Gm54799 ENSMUST00020182334.1 Gm54799 (from geneSymbol) uc288xbk.1 uc288xbk.1 
ENSMUST00020182335.1 Gm55342 ENSMUST00020182335.1 Gm55342 (from geneSymbol) LF204496 uc288xbl.1 uc288xbl.1 
ENSMUST00020182336.1 Gm54389 ENSMUST00020182336.1 Gm54389 (from geneSymbol) uc288xbm.1 uc288xbm.1 
ENSMUST00020182337.1 Gm56445 ENSMUST00020182337.1 Gm56445 (from geneSymbol) LF193483 uc288xbn.1 uc288xbn.1 
ENSMUST00020182338.1 Gm54903 ENSMUST00020182338.1 Gm54903 (from geneSymbol) uc288xbo.1 uc288xbo.1 
ENSMUST00020182339.1 Gm54592 ENSMUST00020182339.1 Gm54592 (from geneSymbol) uc288xbp.1 uc288xbp.1 
ENSMUST00020182340.1 Gm55909 ENSMUST00020182340.1 Gm55909 (from geneSymbol) LF201027 uc288xbq.1 uc288xbq.1 
ENSMUST00020182341.1 Gm55670 ENSMUST00020182341.1 Gm55670 (from geneSymbol) AK039279 uc288xbr.1 uc288xbr.1 
ENSMUST00020182342.1 Gm56146 ENSMUST00020182342.1 Gm56146 (from geneSymbol) uc288xbs.1 uc288xbs.1 
ENSMUST00020182343.1 Gm55762 ENSMUST00020182343.1 Gm55762 (from geneSymbol) DQ541194 uc288xbt.1 uc288xbt.1 
ENSMUST00020182344.1 Gm55045 ENSMUST00020182344.1 Gm55045 (from geneSymbol) uc288xbu.1 uc288xbu.1 
ENSMUST00020182345.1 Gm56199 ENSMUST00020182345.1 Gm56199 (from geneSymbol) uc288xbv.1 uc288xbv.1 
ENSMUST00020182346.1 Gm56347 ENSMUST00020182346.1 Gm56347 (from geneSymbol) uc288xbw.1 uc288xbw.1 
ENSMUST00020182347.1 Gm55246 ENSMUST00020182347.1 Gm55246 (from geneSymbol) uc288xbx.1 uc288xbx.1 
ENSMUST00020182348.1 Gm55374 ENSMUST00020182348.1 Gm55374 (from geneSymbol) uc288xby.1 uc288xby.1 
ENSMUST00020182349.1 Gm54627 ENSMUST00020182349.1 Gm54627 (from geneSymbol) uc288xbz.1 uc288xbz.1 
ENSMUST00020182350.1 Snora34 ENSMUST00020182350.1 small nucleolar RNA, H/ACA box 34 (from RefSeq NR_034051.1) NR_034051 uc288xca.1 uc288xca.1 
ENSMUST00020182351.1 Gm54971 ENSMUST00020182351.1 Gm54971 (from geneSymbol) uc288xcb.1 uc288xcb.1 
ENSMUST00020182352.1 Gm54522 ENSMUST00020182352.1 Gm54522 (from geneSymbol) uc288xcc.1 uc288xcc.1 
ENSMUST00020182353.1 Gm54470 ENSMUST00020182353.1 Gm54470 (from geneSymbol) uc288xcd.1 uc288xcd.1 
ENSMUST00020182354.1 Gm55047 ENSMUST00020182354.1 Gm55047 (from geneSymbol) LF197285 uc288xce.1 uc288xce.1 
ENSMUST00020182355.1 Gm54717 ENSMUST00020182355.1 Gm54717 (from geneSymbol) uc288xcf.1 uc288xcf.1 
ENSMUST00020182356.1 Gm56183 ENSMUST00020182356.1 Gm56183 (from geneSymbol) AB352279 uc288xcg.1 uc288xcg.1 
ENSMUST00020182357.1 Gm55401 ENSMUST00020182357.1 Gm55401 (from geneSymbol) uc288xch.1 uc288xch.1 
ENSMUST00020182358.1 Gm55238 ENSMUST00020182358.1 Gm55238 (from geneSymbol) uc288xci.1 uc288xci.1 
ENSMUST00020182359.1 Gm56115 ENSMUST00020182359.1 Gm56115 (from geneSymbol) uc288xcj.1 uc288xcj.1 
ENSMUST00020182360.1 Gm55961 ENSMUST00020182360.1 Gm55961 (from geneSymbol) uc288xck.1 uc288xck.1 
ENSMUST00020182361.1 Gm55531 ENSMUST00020182361.1 Gm55531 (from geneSymbol) DQ311523 uc288xcl.1 uc288xcl.1 
ENSMUST00020182362.1 Gm56307 ENSMUST00020182362.1 Gm56307 (from geneSymbol) AB352621 uc288xcm.1 uc288xcm.1 
ENSMUST00020182363.1 Gm56125 ENSMUST00020182363.1 Gm56125 (from geneSymbol) DQ311523 uc288xcn.1 uc288xcn.1 
ENSMUST00020182364.1 Gm54878 ENSMUST00020182364.1 Gm54878 (from geneSymbol) uc288xco.1 uc288xco.1 
ENSMUST00020182365.1 Gm54532 ENSMUST00020182365.1 Gm54532 (from geneSymbol) uc288xcp.1 uc288xcp.1 
ENSMUST00020182366.1 Gm56403 ENSMUST00020182366.1 Gm56403 (from geneSymbol) uc288xcq.1 uc288xcq.1 
ENSMUST00020182367.1 Gm54606 ENSMUST00020182367.1 Gm54606 (from geneSymbol) uc288xcr.1 uc288xcr.1 
ENSMUST00020182368.1 Gm54508 ENSMUST00020182368.1 Gm54508 (from geneSymbol) uc288xcs.1 uc288xcs.1 
ENSMUST00020182369.1 Gm54777 ENSMUST00020182369.1 Gm54777 (from geneSymbol) uc288xct.1 uc288xct.1 
ENSMUST00020182370.1 Gm55128 ENSMUST00020182370.1 Gm55128 (from geneSymbol) uc288xcu.1 uc288xcu.1 
ENSMUST00020182371.1 Gm56341 ENSMUST00020182371.1 Gm56341 (from geneSymbol) uc288xcv.1 uc288xcv.1 
ENSMUST00020182372.1 Gm56273 ENSMUST00020182372.1 Gm56273 (from geneSymbol) uc288xcw.1 uc288xcw.1 
ENSMUST00020182373.1 Gm54528 ENSMUST00020182373.1 Gm54528 (from geneSymbol) AK051312 uc288xcx.1 uc288xcx.1 
ENSMUST00020182374.1 Gm54859 ENSMUST00020182374.1 Gm54859 (from geneSymbol) uc288xcy.1 uc288xcy.1 
ENSMUST00020182375.1 Gm54453 ENSMUST00020182375.1 Gm54453 (from geneSymbol) uc288xcz.1 uc288xcz.1 
ENSMUST00020182376.1 Gm55290 ENSMUST00020182376.1 Gm55290 (from geneSymbol) uc288xda.1 uc288xda.1 
ENSMUST00020182377.1 Gm55425 ENSMUST00020182377.1 Gm55425 (from geneSymbol) uc288xdb.1 uc288xdb.1 
ENSMUST00020182378.1 Gm55986 ENSMUST00020182378.1 Gm55986 (from geneSymbol) LF194725 uc288xdc.1 uc288xdc.1 
ENSMUST00020182379.1 Gm54952 ENSMUST00020182379.1 Gm54952 (from geneSymbol) uc288xdd.1 uc288xdd.1 
ENSMUST00020182380.1 Gm56246 ENSMUST00020182380.1 Gm56246 (from geneSymbol) uc288xde.1 uc288xde.1 
ENSMUST00020182381.1 Gm56428 ENSMUST00020182381.1 Gm56428 (from geneSymbol) LF192526 uc288xdf.1 uc288xdf.1 
ENSMUST00020182382.1 Gm55137 ENSMUST00020182382.1 Gm55137 (from geneSymbol) uc288xdg.1 uc288xdg.1 
ENSMUST00020182383.1 Gm54751 ENSMUST00020182383.1 Gm54751 (from geneSymbol) DQ543817 uc288xdh.1 uc288xdh.1 
ENSMUST00020182384.1 Gm55753 ENSMUST00020182384.1 Gm55753 (from geneSymbol) uc288xdi.1 uc288xdi.1 
ENSMUST00020182385.1 Gm56047 ENSMUST00020182385.1 Gm56047 (from geneSymbol) uc288xdj.1 uc288xdj.1 
ENSMUST00020182386.1 Gm55919 ENSMUST00020182386.1 Gm55919 (from geneSymbol) uc288xdk.1 uc288xdk.1 
ENSMUST00020182387.1 Gm56044 ENSMUST00020182387.1 Gm56044 (from geneSymbol) uc288xdl.1 uc288xdl.1 
ENSMUST00020182388.1 Gm55802 ENSMUST00020182388.1 Gm55802 (from geneSymbol) uc288xdm.1 uc288xdm.1 
ENSMUST00020182389.1 Gm55667 ENSMUST00020182389.1 Gm55667 (from geneSymbol) uc288xdn.1 uc288xdn.1 
ENSMUST00020182390.1 Gm55618 ENSMUST00020182390.1 Gm55618 (from geneSymbol) uc288xdo.1 uc288xdo.1 
ENSMUST00020182391.1 Gm54966 ENSMUST00020182391.1 Gm54966 (from geneSymbol) uc288xdp.1 uc288xdp.1 
ENSMUST00020182392.1 Gm56085 ENSMUST00020182392.1 Gm56085 (from geneSymbol) uc288xdq.1 uc288xdq.1 
ENSMUST00020182393.1 Gm56379 ENSMUST00020182393.1 Gm56379 (from geneSymbol) AB352500 uc288xdr.1 uc288xdr.1 
ENSMUST00020182394.1 Gm55450 ENSMUST00020182394.1 Gm55450 (from geneSymbol) uc288xds.1 uc288xds.1 
ENSMUST00020182395.1 Gm54963 ENSMUST00020182395.1 Gm54963 (from geneSymbol) uc288xdt.1 uc288xdt.1 
ENSMUST00020182396.1 Gm54391 ENSMUST00020182396.1 Gm54391 (from geneSymbol) uc288xdu.1 uc288xdu.1 
ENSMUST00020182397.1 Gm56162 ENSMUST00020182397.1 Gm56162 (from geneSymbol) uc288xdv.1 uc288xdv.1 
ENSMUST00020182398.1 Gm54749 ENSMUST00020182398.1 Gm54749 (from geneSymbol) uc288xdw.1 uc288xdw.1 
ENSMUST00020182399.1 Gm55669 ENSMUST00020182399.1 Gm55669 (from geneSymbol) uc288xdx.1 uc288xdx.1 
ENSMUST00020182400.1 Gm54397 ENSMUST00020182400.1 Gm54397 (from geneSymbol) AB352282 uc288xdy.1 uc288xdy.1 
ENSMUST00020182401.1 Gm54857 ENSMUST00020182401.1 Gm54857 (from geneSymbol) uc288xdz.1 uc288xdz.1 
ENSMUST00020182402.1 Gm55324 ENSMUST00020182402.1 Gm55324 (from geneSymbol) uc288xea.1 uc288xea.1 
ENSMUST00020182403.1 Gm56130 ENSMUST00020182403.1 Gm56130 (from geneSymbol) uc288xeb.1 uc288xeb.1 
ENSMUST00020182404.1 Gm55590 ENSMUST00020182404.1 Gm55590 (from geneSymbol) uc288xec.1 uc288xec.1 
ENSMUST00020182405.1 Gm55492 ENSMUST00020182405.1 Gm55492 (from geneSymbol) uc288xed.1 uc288xed.1 
ENSMUST00020182406.1 Gm55337 ENSMUST00020182406.1 Gm55337 (from geneSymbol) uc288xee.1 uc288xee.1 
ENSMUST00020182407.1 Gm55284 ENSMUST00020182407.1 Gm55284 (from geneSymbol) uc288xef.1 uc288xef.1 
ENSMUST00020182408.1 Gm54834 ENSMUST00020182408.1 Gm54834 (from geneSymbol) uc288xeg.1 uc288xeg.1 
ENSMUST00020182409.1 Gm55603 ENSMUST00020182409.1 Gm55603 (from geneSymbol) uc288xeh.1 uc288xeh.1 
ENSMUST00020182410.1 Gm54937 ENSMUST00020182410.1 Gm54937 (from geneSymbol) uc288xei.1 uc288xei.1 
ENSMUST00020182411.1 Gm55989 ENSMUST00020182411.1 Gm55989 (from geneSymbol) uc288xej.1 uc288xej.1 
ENSMUST00020182412.1 Gm54954 ENSMUST00020182412.1 Gm54954 (from geneSymbol) AB352541 uc288xek.1 uc288xek.1 
ENSMUST00020182413.1 Gm56470 ENSMUST00020182413.1 Gm56470 (from geneSymbol) uc288xel.1 uc288xel.1 
ENSMUST00020182414.1 Gm54934 ENSMUST00020182414.1 Gm54934 (from geneSymbol) uc288xem.1 uc288xem.1 
ENSMUST00020182415.1 Gm55208 ENSMUST00020182415.1 Gm55208 (from geneSymbol) uc288xen.1 uc288xen.1 
ENSMUST00020182416.1 Gm56279 ENSMUST00020182416.1 Gm56279 (from geneSymbol) uc288xeo.1 uc288xeo.1 
ENSMUST00020182417.1 Gm54722 ENSMUST00020182417.1 Gm54722 (from geneSymbol) uc288xep.1 uc288xep.1 
ENSMUST00020182418.1 Gm55886 ENSMUST00020182418.1 Gm55886 (from geneSymbol) uc288xeq.1 uc288xeq.1 
ENSMUST00020182419.1 Gm55475 ENSMUST00020182419.1 Gm55475 (from geneSymbol) uc288xer.1 uc288xer.1 
ENSMUST00020182420.1 Gm54488 ENSMUST00020182420.1 Gm54488 (from geneSymbol) uc288xes.1 uc288xes.1 
ENSMUST00020182421.1 Gm55529 ENSMUST00020182421.1 Gm55529 (from geneSymbol) uc288xet.1 uc288xet.1 
ENSMUST00020182422.1 Gm55993 ENSMUST00020182422.1 Gm55993 (from geneSymbol) uc288xeu.1 uc288xeu.1 
ENSMUST00020182423.1 Scarna3b ENSMUST00020182423.1 Scarna3b (from geneSymbol) AF357403 uc288xev.1 uc288xev.1 
ENSMUST00020182424.1 Snord80 ENSMUST00020182424.1 Snord80 (from geneSymbol) uc288xew.1 uc288xew.1 
ENSMUST00020182425.1 Gm56071 ENSMUST00020182425.1 Gm56071 (from geneSymbol) uc288xex.1 uc288xex.1 
ENSMUST00020182426.1 Gm55969 ENSMUST00020182426.1 Gm55969 (from geneSymbol) uc288xey.1 uc288xey.1 
ENSMUST00020182427.1 Gm54981 ENSMUST00020182427.1 Gm54981 (from geneSymbol) DQ311494 uc288xez.1 uc288xez.1 
ENSMUST00020182428.1 ENSMUSG00002075729 ENSMUST00020182428.1 ENSMUSG00002075729 (from geneSymbol) AB351420 uc288xfa.1 uc288xfa.1 
ENSMUST00020182429.1 Gm54342 ENSMUST00020182429.1 Gm54342 (from geneSymbol) DQ311494 uc288xfb.1 uc288xfb.1 
ENSMUST00020182430.1 Gm54448 ENSMUST00020182430.1 Gm54448 (from geneSymbol) uc288xfc.1 uc288xfc.1 
ENSMUST00020182431.1 Gm26047 ENSMUST00020182431.1 Gm26047 (from geneSymbol) uc288xfd.1 uc288xfd.1 
ENSMUST00020182432.1 Gm55106 ENSMUST00020182432.1 Gm55106 (from geneSymbol) uc288xfe.1 uc288xfe.1 
ENSMUST00020182433.1 Gm55838 ENSMUST00020182433.1 Gm55838 (from geneSymbol) uc288xff.1 uc288xff.1 
ENSMUST00020182434.1 Gm56444 ENSMUST00020182434.1 Gm56444 (from geneSymbol) uc288xfg.1 uc288xfg.1 
ENSMUST00020182435.1 Gm55702 ENSMUST00020182435.1 Gm55702 (from geneSymbol) uc288xfh.1 uc288xfh.1 
ENSMUST00020182436.1 Gm55614 ENSMUST00020182436.1 Gm55614 (from geneSymbol) uc288xfi.1 uc288xfi.1 
ENSMUST00020182437.1 Gm54691 ENSMUST00020182437.1 Gm54691 (from geneSymbol) uc288xfj.1 uc288xfj.1 
ENSMUST00020182438.1 Gm54439 ENSMUST00020182438.1 Gm54439 (from geneSymbol) uc288xfk.1 uc288xfk.1 
ENSMUST00020182439.1 Gm54435 ENSMUST00020182439.1 Gm54435 (from geneSymbol) uc288xfl.1 uc288xfl.1 
ENSMUST00020182440.1 Gm55433 ENSMUST00020182440.1 Gm55433 (from geneSymbol) DQ311494 uc288xfm.1 uc288xfm.1 
ENSMUST00020182441.1 Gm56249 ENSMUST00020182441.1 Gm56249 (from geneSymbol) uc288xfn.1 uc288xfn.1 
ENSMUST00020182442.1 Gm54636 ENSMUST00020182442.1 Gm54636 (from geneSymbol) uc288xfo.1 uc288xfo.1 
ENSMUST00020182443.1 Gm55805 ENSMUST00020182443.1 Gm55805 (from geneSymbol) uc288xfp.1 uc288xfp.1 
ENSMUST00020182444.1 Gm55226 ENSMUST00020182444.1 Gm55226 (from geneSymbol) AB352279 uc288xfq.1 uc288xfq.1 
ENSMUST00020182445.1 Gm56075 ENSMUST00020182445.1 Gm56075 (from geneSymbol) uc288xfr.1 uc288xfr.1 
ENSMUST00020182446.1 Gm56214 ENSMUST00020182446.1 Gm56214 (from geneSymbol) uc288xfs.1 uc288xfs.1 
ENSMUST00020182447.1 Gm55315 ENSMUST00020182447.1 Gm55315 (from geneSymbol) uc288xft.1 uc288xft.1 
ENSMUST00020182448.1 Gm56322 ENSMUST00020182448.1 Gm56322 (from geneSymbol) uc288xfu.1 uc288xfu.1 
ENSMUST00020182449.1 Gm54641 ENSMUST00020182449.1 Gm54641 (from geneSymbol) uc288xfv.1 uc288xfv.1 
ENSMUST00020182450.1 Gm54678 ENSMUST00020182450.1 Gm54678 (from geneSymbol) LF199360 uc288xfw.1 uc288xfw.1 
ENSMUST00020182451.1 Gm54580 ENSMUST00020182451.1 Gm54580 (from geneSymbol) uc288xfx.1 uc288xfx.1 
ENSMUST00020182452.1 Gm56025 ENSMUST00020182452.1 Gm56025 (from geneSymbol) uc288xfy.1 uc288xfy.1 
ENSMUST00020182453.1 Gm55671 ENSMUST00020182453.1 Gm55671 (from geneSymbol) uc288xfz.1 uc288xfz.1 
ENSMUST00020182454.1 Gm54829 ENSMUST00020182454.1 Gm54829 (from geneSymbol) uc288xga.1 uc288xga.1 
ENSMUST00020182455.1 Gm55476 ENSMUST00020182455.1 Gm55476 (from geneSymbol) uc288xgb.1 uc288xgb.1 
ENSMUST00020182456.1 Gm56319 ENSMUST00020182456.1 Gm56319 (from geneSymbol) uc288xgc.1 uc288xgc.1 
ENSMUST00020182457.1 Gm55242 ENSMUST00020182457.1 Gm55242 (from geneSymbol) uc288xgd.1 uc288xgd.1 
ENSMUST00020182458.1 Gm55169 ENSMUST00020182458.1 Gm55169 (from geneSymbol) DQ311494 uc288xge.1 uc288xge.1 
ENSMUST00020182459.1 Gm54471 ENSMUST00020182459.1 Gm54471 (from geneSymbol) LF199435 uc288xgf.1 uc288xgf.1 
ENSMUST00020182460.1 Gm56248 ENSMUST00020182460.1 Gm56248 (from geneSymbol) uc288xgg.1 uc288xgg.1 
ENSMUST00020182461.1 Gm55120 ENSMUST00020182461.1 Gm55120 (from geneSymbol) uc288xgh.1 uc288xgh.1 
ENSMUST00020182462.1 Gm55595 ENSMUST00020182462.1 Gm55595 (from geneSymbol) uc288xgi.1 uc288xgi.1 
ENSMUST00020182463.1 Gm56459 ENSMUST00020182463.1 Gm56459 (from geneSymbol) LF192498 uc288xgj.1 uc288xgj.1 
ENSMUST00020182464.1 Gm55319 ENSMUST00020182464.1 Gm55319 (from geneSymbol) uc288xgk.1 uc288xgk.1 
ENSMUST00020182465.1 Gm55760 ENSMUST00020182465.1 Gm55760 (from geneSymbol) uc288xgl.1 uc288xgl.1 
ENSMUST00020182466.1 Gm56468 ENSMUST00020182466.1 Gm56468 (from geneSymbol) uc288xgm.1 uc288xgm.1 
ENSMUST00020182467.1 Gm54832 ENSMUST00020182467.1 Gm54832 (from geneSymbol) uc288xgn.1 uc288xgn.1 
ENSMUST00020182468.1 Gm56023 ENSMUST00020182468.1 Gm56023 (from geneSymbol) uc288xgo.1 uc288xgo.1 
ENSMUST00020182469.1 Gm55385 ENSMUST00020182469.1 Gm55385 (from geneSymbol) uc288xgp.1 uc288xgp.1 
ENSMUST00020182470.1 Gm55381 ENSMUST00020182470.1 Gm55381 (from geneSymbol) uc288xgq.1 uc288xgq.1 
ENSMUST00020182471.1 Gm54647 ENSMUST00020182471.1 Gm54647 (from geneSymbol) uc288xgr.1 uc288xgr.1 
ENSMUST00020182472.1 Gm55800 ENSMUST00020182472.1 Gm55800 (from geneSymbol) AB352500 uc288xgs.1 uc288xgs.1 
ENSMUST00020182473.1 Gm55158 ENSMUST00020182473.1 Gm55158 (from geneSymbol) uc288xgt.1 uc288xgt.1 
ENSMUST00020182474.1 Gm54748 ENSMUST00020182474.1 Gm54748 (from geneSymbol) uc288xgu.1 uc288xgu.1 
ENSMUST00020182475.1 Gm54464 ENSMUST00020182475.1 Gm54464 (from geneSymbol) LF235978 uc288xgv.1 uc288xgv.1 
ENSMUST00020182476.1 Gm55435 ENSMUST00020182476.1 Gm55435 (from geneSymbol) uc288xgw.1 uc288xgw.1 
ENSMUST00020182477.1 Gm54855 ENSMUST00020182477.1 Gm54855 (from geneSymbol) AB352978 uc288xgx.1 uc288xgx.1 
ENSMUST00020182478.1 Gm55199 ENSMUST00020182478.1 Gm55199 (from geneSymbol) uc288xgy.1 uc288xgy.1 
ENSMUST00020182479.1 Gm54671 ENSMUST00020182479.1 Gm54671 (from geneSymbol) uc288xgz.1 uc288xgz.1 
ENSMUST00020182480.1 Gm54490 ENSMUST00020182480.1 Gm54490 (from geneSymbol) uc288xha.1 uc288xha.1 
ENSMUST00020182481.1 Gm56365 ENSMUST00020182481.1 Gm56365 (from geneSymbol) uc288xhb.1 uc288xhb.1 
ENSMUST00020182482.1 Gm54896 ENSMUST00020182482.1 Gm54896 (from geneSymbol) uc288xhc.1 uc288xhc.1 
ENSMUST00020182483.1 Gm56412 ENSMUST00020182483.1 Gm56412 (from geneSymbol) uc288xhd.1 uc288xhd.1 
ENSMUST00020182484.1 Gm56388 ENSMUST00020182484.1 Gm56388 (from geneSymbol) uc288xhe.1 uc288xhe.1 
ENSMUST00020182485.1 Gm55579 ENSMUST00020182485.1 Gm55579 (from geneSymbol) uc288xhf.1 uc288xhf.1 
ENSMUST00020182486.1 Gm56087 ENSMUST00020182486.1 Gm56087 (from geneSymbol) uc288xhg.1 uc288xhg.1 
ENSMUST00020182487.1 Gm56302 ENSMUST00020182487.1 Gm56302 (from geneSymbol) uc288xhh.1 uc288xhh.1 
ENSMUST00020182488.1 Gm55166 ENSMUST00020182488.1 Gm55166 (from geneSymbol) uc288xhi.1 uc288xhi.1 
ENSMUST00020182489.1 Gm55131 ENSMUST00020182489.1 Gm55131 (from geneSymbol) uc288xhj.1 uc288xhj.1 
ENSMUST00020182490.1 Gm55741 ENSMUST00020182490.1 Gm55741 (from geneSymbol) uc288xhk.1 uc288xhk.1 
ENSMUST00020182491.1 Gm55379 ENSMUST00020182491.1 Gm55379 (from geneSymbol) uc288xhl.1 uc288xhl.1 
ENSMUST00020182492.1 Gm56250 ENSMUST00020182492.1 Gm56250 (from geneSymbol) uc288xhm.1 uc288xhm.1 
ENSMUST00020182493.1 Gm55269 ENSMUST00020182493.1 Gm55269 (from geneSymbol) uc288xhn.1 uc288xhn.1 
ENSMUST00020182494.1 Gm55841 ENSMUST00020182494.1 Gm55841 (from geneSymbol) LF200996 uc288xho.1 uc288xho.1 
ENSMUST00020182495.1 Gm56266 ENSMUST00020182495.1 Gm56266 (from geneSymbol) uc288xhp.1 uc288xhp.1 
ENSMUST00020182496.1 Gm56326 ENSMUST00020182496.1 Gm56326 (from geneSymbol) uc288xhq.1 uc288xhq.1 
ENSMUST00020182497.1 Gm56324 ENSMUST00020182497.1 Gm56324 (from geneSymbol) LF193251 uc288xhr.1 uc288xhr.1 
ENSMUST00020182498.1 Gm55295 ENSMUST00020182498.1 Gm55295 (from geneSymbol) uc288xhs.1 uc288xhs.1 
ENSMUST00020182499.1 Gm54539 ENSMUST00020182499.1 Gm54539 (from geneSymbol) uc288xht.1 uc288xht.1 
ENSMUST00020182500.1 Gm56216 ENSMUST00020182500.1 Gm56216 (from geneSymbol) uc288xhu.1 uc288xhu.1 
ENSMUST00020182501.1 Gm54523 ENSMUST00020182501.1 Gm54523 (from geneSymbol) uc288xhv.1 uc288xhv.1 
ENSMUST00020182502.1 Gm55241 ENSMUST00020182502.1 Gm55241 (from geneSymbol) LF262441 uc288xhw.1 uc288xhw.1 
ENSMUST00020182503.1 Gm56082 ENSMUST00020182503.1 Gm56082 (from geneSymbol) uc288xhx.1 uc288xhx.1 
ENSMUST00020182504.1 Gm56106 ENSMUST00020182504.1 Gm56106 (from geneSymbol) uc288xhy.1 uc288xhy.1 
ENSMUST00020182505.1 Gm54495 ENSMUST00020182505.1 Gm54495 (from geneSymbol) uc288xhz.1 uc288xhz.1 
ENSMUST00020182506.1 Gm55855 ENSMUST00020182506.1 Gm55855 (from geneSymbol) uc288xia.1 uc288xia.1 
ENSMUST00020182507.1 Gm55881 ENSMUST00020182507.1 Gm55881 (from geneSymbol) uc288xib.1 uc288xib.1 
ENSMUST00020182508.1 Gm54381 ENSMUST00020182508.1 Gm54381 (from geneSymbol) uc288xic.1 uc288xic.1 
ENSMUST00020182509.1 Gm55888 ENSMUST00020182509.1 Gm55888 (from geneSymbol) DQ311494 uc288xid.1 uc288xid.1 
ENSMUST00020182510.1 Gm54547 ENSMUST00020182510.1 Gm54547 (from geneSymbol) DQ311494 uc288xie.1 uc288xie.1 
ENSMUST00020182511.1 Snord3b2 ENSMUST00020182511.1 Snord3b2 (from geneSymbol) AK019039 uc288xif.1 uc288xif.1 
ENSMUST00020182512.1 Gm54778 ENSMUST00020182512.1 Gm54778 (from geneSymbol) uc288xig.1 uc288xig.1 
ENSMUST00020182513.1 Gm54432 ENSMUST00020182513.1 Gm54432 (from geneSymbol) uc288xih.1 uc288xih.1 
ENSMUST00020182514.1 Gm55011 ENSMUST00020182514.1 Gm55011 (from geneSymbol) DQ311494 uc288xii.1 uc288xii.1 
ENSMUST00020182515.1 Gm56477 ENSMUST00020182515.1 Gm56477 (from geneSymbol) LF193303 uc288xij.1 uc288xij.1 
ENSMUST00020182516.1 Gm55783 ENSMUST00020182516.1 Gm55783 (from geneSymbol) LF204070 uc288xik.1 uc288xik.1 
ENSMUST00020182517.1 Gm55699 ENSMUST00020182517.1 Gm55699 (from geneSymbol) uc288xil.1 uc288xil.1 
ENSMUST00020182518.1 Gm55710 ENSMUST00020182518.1 Gm55710 (from geneSymbol) uc288xim.1 uc288xim.1 
ENSMUST00020182519.1 Gm55499 ENSMUST00020182519.1 Gm55499 (from geneSymbol) uc288xin.1 uc288xin.1 
ENSMUST00020182520.1 Gm55417 ENSMUST00020182520.1 Gm55417 (from geneSymbol) uc288xio.1 uc288xio.1 
ENSMUST00020182521.1 Gm54755 ENSMUST00020182521.1 Gm54755 (from geneSymbol) uc288xip.1 uc288xip.1 
ENSMUST00020182522.1 Gm55139 ENSMUST00020182522.1 Gm55139 (from geneSymbol) uc288xiq.1 uc288xiq.1 
ENSMUST00020182523.1 Gm54947 ENSMUST00020182523.1 Gm54947 (from geneSymbol) uc288xir.1 uc288xir.1 
ENSMUST00020182524.1 Gm54756 ENSMUST00020182524.1 Gm54756 (from geneSymbol) uc288xis.1 uc288xis.1 
ENSMUST00020182525.1 Gm55551 ENSMUST00020182525.1 Gm55551 (from geneSymbol) uc288xit.1 uc288xit.1 
ENSMUST00020182526.1 Gm55455 ENSMUST00020182526.1 Gm55455 (from geneSymbol) uc288xiu.1 uc288xiu.1 
ENSMUST00020182527.1 Gm54923 ENSMUST00020182527.1 Gm54923 (from geneSymbol) uc288xiv.1 uc288xiv.1 
ENSMUST00020182528.1 Gm54867 ENSMUST00020182528.1 Gm54867 (from geneSymbol) uc288xiw.1 uc288xiw.1 
ENSMUST00020182529.1 Gm55078 ENSMUST00020182529.1 Gm55078 (from geneSymbol) uc288xix.1 uc288xix.1 
ENSMUST00020182530.1 Gm55790 ENSMUST00020182530.1 Gm55790 (from geneSymbol) uc288xiy.1 uc288xiy.1 
ENSMUST00020182531.1 Gm54353 ENSMUST00020182531.1 Gm54353 (from geneSymbol) uc288xiz.1 uc288xiz.1 
ENSMUST00020182532.1 Gm55171 ENSMUST00020182532.1 Gm55171 (from geneSymbol) uc288xja.1 uc288xja.1 
ENSMUST00020182533.1 Gm56053 ENSMUST00020182533.1 Gm56053 (from geneSymbol) uc288xjb.1 uc288xjb.1 
ENSMUST00020182534.1 Gm55851 ENSMUST00020182534.1 Gm55851 (from geneSymbol) uc288xjc.1 uc288xjc.1 
ENSMUST00020182535.1 Gm54974 ENSMUST00020182535.1 Gm54974 (from geneSymbol) DQ311494 uc288xjd.1 uc288xjd.1 
ENSMUST00020182536.1 Gm56080 ENSMUST00020182536.1 Gm56080 (from geneSymbol) uc288xje.1 uc288xje.1 
ENSMUST00020182537.1 Gm54824 ENSMUST00020182537.1 Gm54824 (from geneSymbol) uc288xjf.1 uc288xjf.1 
ENSMUST00020182538.1 Gm55654 ENSMUST00020182538.1 Gm55654 (from geneSymbol) uc288xjg.1 uc288xjg.1 
ENSMUST00020182539.1 Gm54423 ENSMUST00020182539.1 Gm54423 (from geneSymbol) DQ311494 uc288xjh.1 uc288xjh.1 
ENSMUST00020182540.1 Gm55389 ENSMUST00020182540.1 Gm55389 (from geneSymbol) uc288xji.1 uc288xji.1 
ENSMUST00020182541.1 Gm56210 ENSMUST00020182541.1 Gm56210 (from geneSymbol) uc288xjj.1 uc288xjj.1 
ENSMUST00020182542.1 Gm55936 ENSMUST00020182542.1 Gm55936 (from geneSymbol) uc288xjk.1 uc288xjk.1 
ENSMUST00020182543.1 Gm54904 ENSMUST00020182543.1 Gm54904 (from geneSymbol) uc288xjl.1 uc288xjl.1 
ENSMUST00020182544.1 Gm54408 ENSMUST00020182544.1 Gm54408 (from geneSymbol) uc288xjm.1 uc288xjm.1 
ENSMUST00020182546.1 Gm55860 ENSMUST00020182546.1 Gm55860 (from geneSymbol) uc288xjo.1 uc288xjo.1 
ENSMUST00020182547.1 Gm55545 ENSMUST00020182547.1 Gm55545 (from geneSymbol) AB351420 uc288xjp.1 uc288xjp.1 
ENSMUST00020182548.1 Gm54372 ENSMUST00020182548.1 Gm54372 (from geneSymbol) uc288xjq.1 uc288xjq.1 
ENSMUST00020182549.1 Gm56155 ENSMUST00020182549.1 Gm56155 (from geneSymbol) uc288xjr.1 uc288xjr.1 
ENSMUST00020182550.1 Gm55965 ENSMUST00020182550.1 Gm55965 (from geneSymbol) uc288xjs.1 uc288xjs.1 
ENSMUST00020182551.1 Gm55657 ENSMUST00020182551.1 Gm55657 (from geneSymbol) uc288xjt.1 uc288xjt.1 
ENSMUST00020182552.1 Gm54940 ENSMUST00020182552.1 Gm54940 (from geneSymbol) uc288xju.1 uc288xju.1 
ENSMUST00020182553.1 Gm55249 ENSMUST00020182553.1 Gm55249 (from geneSymbol) uc288xjv.1 uc288xjv.1 
ENSMUST00020182554.1 Gm55412 ENSMUST00020182554.1 Gm55412 (from geneSymbol) uc288xjw.1 uc288xjw.1 
ENSMUST00020182555.1 Gm54992 ENSMUST00020182555.1 Gm54992 (from geneSymbol) uc288xjx.1 uc288xjx.1 
ENSMUST00020182556.1 Gm56474 ENSMUST00020182556.1 Gm56474 (from geneSymbol) uc288xjy.1 uc288xjy.1 
ENSMUST00020182557.1 Gm54365 ENSMUST00020182557.1 Gm54365 (from geneSymbol) uc288xjz.1 uc288xjz.1 
ENSMUST00020182558.1 Gm56188 ENSMUST00020182558.1 Gm56188 (from geneSymbol) uc288xka.1 uc288xka.1 
ENSMUST00020182559.1 Gm55041 ENSMUST00020182559.1 Gm55041 (from geneSymbol) uc288xkb.1 uc288xkb.1 
ENSMUST00020182560.1 Gm55525 ENSMUST00020182560.1 Gm55525 (from geneSymbol) AK033579 uc288xkc.1 uc288xkc.1 
ENSMUST00020182561.1 Gm56010 ENSMUST00020182561.1 Gm56010 (from geneSymbol) uc288xkd.1 uc288xkd.1 
ENSMUST00020182562.1 Gm56374 ENSMUST00020182562.1 Gm56374 (from geneSymbol) uc288xke.1 uc288xke.1 
ENSMUST00020182563.1 Gm55438 ENSMUST00020182563.1 Gm55438 (from geneSymbol) uc288xkf.1 uc288xkf.1 
ENSMUST00020182564.1 Gm56176 ENSMUST00020182564.1 Gm56176 (from geneSymbol) AB352282 uc288xkg.1 uc288xkg.1 
ENSMUST00020182565.1 Gm55366 ENSMUST00020182565.1 Gm55366 (from geneSymbol) uc288xkh.1 uc288xkh.1 
ENSMUST00020182566.1 Gm54909 ENSMUST00020182566.1 Gm54909 (from geneSymbol) uc288xki.1 uc288xki.1 
ENSMUST00020182567.1 Gm55100 ENSMUST00020182567.1 Gm55100 (from geneSymbol) uc288xkj.1 uc288xkj.1 
ENSMUST00020182568.1 Gm26457 ENSMUST00020182568.1 Gm26457 (from geneSymbol) uc288xkk.1 uc288xkk.1 
ENSMUST00020182569.1 Gm54945 ENSMUST00020182569.1 Gm54945 (from geneSymbol) uc288xkl.1 uc288xkl.1 
ENSMUST00020182570.1 Gm54948 ENSMUST00020182570.1 Gm54948 (from geneSymbol) uc288xkm.1 uc288xkm.1 
ENSMUST00020182571.1 Gm55443 ENSMUST00020182571.1 Gm55443 (from geneSymbol) uc288xkn.1 uc288xkn.1 
ENSMUST00020182572.1 Gm55506 ENSMUST00020182572.1 Gm55506 (from geneSymbol) uc288xko.1 uc288xko.1 
ENSMUST00020182573.1 Gm54633 ENSMUST00020182573.1 Gm54633 (from geneSymbol) uc288xkp.1 uc288xkp.1 
ENSMUST00020182574.1 Gm55639 ENSMUST00020182574.1 Gm55639 (from geneSymbol) uc288xkq.1 uc288xkq.1 
ENSMUST00020182575.1 Gm55832 ENSMUST00020182575.1 Gm55832 (from geneSymbol) uc288xkr.1 uc288xkr.1 
ENSMUST00020182576.1 Gm54357 ENSMUST00020182576.1 Gm54357 (from geneSymbol) uc288xks.1 uc288xks.1 
ENSMUST00020182577.1 Gm56094 ENSMUST00020182577.1 Gm56094 (from geneSymbol) DQ311494 uc288xkt.1 uc288xkt.1 
ENSMUST00020182578.1 Gm55825 ENSMUST00020182578.1 Gm55825 (from geneSymbol) uc288xku.1 uc288xku.1 
ENSMUST00020182579.1 Gm54816 ENSMUST00020182579.1 Gm54816 (from geneSymbol) uc288xkv.1 uc288xkv.1 
ENSMUST00020182580.1 Gm54831 ENSMUST00020182580.1 Gm54831 (from geneSymbol) uc288xkw.1 uc288xkw.1 
ENSMUST00020182581.1 Gm55739 ENSMUST00020182581.1 Gm55739 (from geneSymbol) uc288xkx.1 uc288xkx.1 
ENSMUST00020182582.1 Gm54985 ENSMUST00020182582.1 Gm54985 (from geneSymbol) uc288xky.1 uc288xky.1 
ENSMUST00020182583.1 Gm54484 ENSMUST00020182583.1 Gm54484 (from geneSymbol) uc288xkz.1 uc288xkz.1 
ENSMUST00020182584.1 Gm55353 ENSMUST00020182584.1 Gm55353 (from geneSymbol) uc288xla.1 uc288xla.1 
ENSMUST00020182585.1 Gm55740 ENSMUST00020182585.1 Gm55740 (from geneSymbol) uc288xlb.1 uc288xlb.1 
ENSMUST00020182586.1 Gm56172 ENSMUST00020182586.1 Gm56172 (from geneSymbol) uc288xlc.1 uc288xlc.1 
ENSMUST00020182587.1 Gm54766 ENSMUST00020182587.1 Gm54766 (from geneSymbol) uc288xld.1 uc288xld.1 
ENSMUST00020182588.1 Gm55911 ENSMUST00020182588.1 Gm55911 (from geneSymbol) uc288xle.1 uc288xle.1 
ENSMUST00020182589.1 Gm56371 ENSMUST00020182589.1 Gm56371 (from geneSymbol) uc288xlf.1 uc288xlf.1 
ENSMUST00020182590.1 Gm54485 ENSMUST00020182590.1 Gm54485 (from geneSymbol) DQ311494 uc288xlg.1 uc288xlg.1 
ENSMUST00020182591.1 Gm55959 ENSMUST00020182591.1 Gm55959 (from geneSymbol) uc288xlh.1 uc288xlh.1 
ENSMUST00020182592.1 Gm54776 ENSMUST00020182592.1 Gm54776 (from geneSymbol) LF195975 uc288xli.1 uc288xli.1 
ENSMUST00020182593.1 Gm56464 ENSMUST00020182593.1 Gm56464 (from geneSymbol) uc288xlj.1 uc288xlj.1 
ENSMUST00020182594.1 Gm55213 ENSMUST00020182594.1 Gm55213 (from geneSymbol) uc288xlk.1 uc288xlk.1 
ENSMUST00020182595.1 Gm54443 ENSMUST00020182595.1 Gm54443 (from geneSymbol) uc288xll.1 uc288xll.1 
ENSMUST00020182596.1 Gm54718 ENSMUST00020182596.1 Gm54718 (from geneSymbol) DQ541194 uc288xlm.1 uc288xlm.1 
ENSMUST00020182597.1 Gm55921 ENSMUST00020182597.1 Gm55921 (from geneSymbol) uc288xln.1 uc288xln.1 
ENSMUST00020182598.1 Gm55038 ENSMUST00020182598.1 Gm55038 (from geneSymbol) uc288xlo.1 uc288xlo.1 
ENSMUST00020182599.1 Gm56084 ENSMUST00020182599.1 Gm56084 (from geneSymbol) uc288xlp.1 uc288xlp.1 
ENSMUST00020182600.1 Gm56006 ENSMUST00020182600.1 Gm56006 (from geneSymbol) uc288xlq.1 uc288xlq.1 
ENSMUST00020182601.1 Gm55059 ENSMUST00020182601.1 Gm55059 (from geneSymbol) uc288xlr.1 uc288xlr.1 
ENSMUST00020182602.1 Gm55441 ENSMUST00020182602.1 Gm55441 (from geneSymbol) uc288xls.1 uc288xls.1 
ENSMUST00020182603.1 Gm55001 ENSMUST00020182603.1 Gm55001 (from geneSymbol) uc288xlt.1 uc288xlt.1 
ENSMUST00020182604.1 Gm56405 ENSMUST00020182604.1 Gm56405 (from geneSymbol) uc288xlu.1 uc288xlu.1 
ENSMUST00020182605.1 Gm55409 ENSMUST00020182605.1 Gm55409 (from geneSymbol) uc288xlv.1 uc288xlv.1 
ENSMUST00020182606.1 Gm55205 ENSMUST00020182606.1 Gm55205 (from geneSymbol) uc288xlw.1 uc288xlw.1 
ENSMUST00020182607.1 Gm55628 ENSMUST00020182607.1 Gm55628 (from geneSymbol) LF235975 uc288xlx.1 uc288xlx.1 
ENSMUST00020182608.1 Gm54531 ENSMUST00020182608.1 Gm54531 (from geneSymbol) uc288xly.1 uc288xly.1 
ENSMUST00020182609.1 Gm54394 ENSMUST00020182609.1 Gm54394 (from geneSymbol) DQ311494 uc288xlz.1 uc288xlz.1 
ENSMUST00020182610.1 Gm55626 ENSMUST00020182610.1 Gm55626 (from geneSymbol) uc288xma.1 uc288xma.1 
ENSMUST00020182611.1 Gm56179 ENSMUST00020182611.1 Gm56179 (from geneSymbol) uc288xmb.1 uc288xmb.1 
ENSMUST00020182612.1 Gm54344 ENSMUST00020182612.1 Gm54344 (from geneSymbol) uc288xmc.1 uc288xmc.1 
ENSMUST00020182613.1 Gm55621 ENSMUST00020182613.1 Gm55621 (from geneSymbol) uc288xmd.1 uc288xmd.1 
ENSMUST00020182614.1 Gm55647 ENSMUST00020182614.1 Gm55647 (from geneSymbol) uc288xme.1 uc288xme.1 
ENSMUST00020182615.1 Gm55207 ENSMUST00020182615.1 Gm55207 (from geneSymbol) LF202103 uc288xmf.1 uc288xmf.1 
ENSMUST00020182616.1 Gm56213 ENSMUST00020182616.1 Gm56213 (from geneSymbol) uc288xmg.1 uc288xmg.1 
ENSMUST00020182617.1 Gm55968 ENSMUST00020182617.1 Gm55968 (from geneSymbol) uc288xmh.1 uc288xmh.1 
ENSMUST00020182618.1 Gm54737 ENSMUST00020182618.1 Gm54737 (from geneSymbol) uc288xmi.1 uc288xmi.1 
ENSMUST00020182619.1 Gm54699 ENSMUST00020182619.1 Gm54699 (from geneSymbol) uc288xmj.1 uc288xmj.1 
ENSMUST00020182620.1 Gm54801 ENSMUST00020182620.1 Gm54801 (from geneSymbol) uc288xmk.1 uc288xmk.1 
ENSMUST00020182621.1 Gm55003 ENSMUST00020182621.1 Gm55003 (from geneSymbol) uc288xml.1 uc288xml.1 
ENSMUST00020182622.1 Gm54850 ENSMUST00020182622.1 Gm54850 (from geneSymbol) uc288xmm.1 uc288xmm.1 
ENSMUST00020182623.1 Gm55444 ENSMUST00020182623.1 Gm55444 (from geneSymbol) uc288xmn.1 uc288xmn.1 
ENSMUST00020182624.1 Gm54566 ENSMUST00020182624.1 Gm54566 (from geneSymbol) uc288xmo.1 uc288xmo.1 
ENSMUST00020182625.1 Gm56396 ENSMUST00020182625.1 Gm56396 (from geneSymbol) uc288xmp.1 uc288xmp.1 
ENSMUST00020182626.1 Gm55092 ENSMUST00020182626.1 Gm55092 (from geneSymbol) uc288xmq.1 uc288xmq.1 
ENSMUST00020182627.1 Gm56378 ENSMUST00020182627.1 Gm56378 (from geneSymbol) uc288xmr.1 uc288xmr.1 
ENSMUST00020182628.1 Gm55229 ENSMUST00020182628.1 Gm55229 (from geneSymbol) uc288xms.1 uc288xms.1 
ENSMUST00020182629.1 Gm55570 ENSMUST00020182629.1 Gm55570 (from geneSymbol) uc288xmt.1 uc288xmt.1 
ENSMUST00020182630.1 Gm55764 ENSMUST00020182630.1 Gm55764 (from geneSymbol) uc288xmu.1 uc288xmu.1 
ENSMUST00020182631.1 Gm56045 ENSMUST00020182631.1 Gm56045 (from geneSymbol) uc288xmv.1 uc288xmv.1 
ENSMUST00020182632.1 Gm54874 ENSMUST00020182632.1 Gm54874 (from geneSymbol) uc288xmw.1 uc288xmw.1 
ENSMUST00020182633.1 Gm55897 ENSMUST00020182633.1 Gm55897 (from geneSymbol) uc288xmx.1 uc288xmx.1 
ENSMUST00020182634.1 Gm55081 ENSMUST00020182634.1 Gm55081 (from geneSymbol) uc288xmy.1 uc288xmy.1 
ENSMUST00020182635.1 Gm54706 ENSMUST00020182635.1 Gm54706 (from geneSymbol) uc288xmz.1 uc288xmz.1 
ENSMUST00020182636.1 Gm55778 ENSMUST00020182636.1 Gm55778 (from geneSymbol) uc288xna.1 uc288xna.1 
ENSMUST00020182637.1 Gm55088 ENSMUST00020182637.1 Gm55088 (from geneSymbol) uc288xnb.1 uc288xnb.1 
ENSMUST00020182638.1 Gm55663 ENSMUST00020182638.1 Gm55663 (from geneSymbol) LF195363 uc288xnc.1 uc288xnc.1 
ENSMUST00020182639.1 Terc ENSMUST00020182639.1 Terc (from geneSymbol) uc288xnd.1 uc288xnd.1 
ENSMUST00020182640.1 Gm55406 ENSMUST00020182640.1 Gm55406 (from geneSymbol) uc288xne.1 uc288xne.1 
ENSMUST00020182641.1 Gm55591 ENSMUST00020182641.1 Gm55591 (from geneSymbol) uc288xnf.1 uc288xnf.1 
ENSMUST00020182642.1 Gm56393 ENSMUST00020182642.1 Gm56393 (from geneSymbol) uc288xng.1 uc288xng.1 
ENSMUST00020182643.1 Gm54687 ENSMUST00020182643.1 Gm54687 (from geneSymbol) uc288xnh.1 uc288xnh.1 
ENSMUST00020182644.1 Gm55549 ENSMUST00020182644.1 Gm55549 (from geneSymbol) uc288xni.1 uc288xni.1 
ENSMUST00020182645.1 Gm55480 ENSMUST00020182645.1 Gm55480 (from geneSymbol) uc288xnj.1 uc288xnj.1 
ENSMUST00020182646.1 Gm55828 ENSMUST00020182646.1 Gm55828 (from geneSymbol) DQ311494 uc288xnk.1 uc288xnk.1 
ENSMUST00020182647.1 Gm55270 ENSMUST00020182647.1 Gm55270 (from geneSymbol) DQ311494 uc288xnl.1 uc288xnl.1 
ENSMUST00020182648.1 Gm56002 ENSMUST00020182648.1 Gm56002 (from geneSymbol) uc288xnm.1 uc288xnm.1 
ENSMUST00020182649.1 Gm55782 ENSMUST00020182649.1 Gm55782 (from geneSymbol) LF204070 uc288xnn.1 uc288xnn.1 
ENSMUST00020182650.1 Gm56301 ENSMUST00020182650.1 Gm56301 (from geneSymbol) uc288xno.1 uc288xno.1 
ENSMUST00020182651.1 Gm56320 ENSMUST00020182651.1 Gm56320 (from geneSymbol) uc288xnp.1 uc288xnp.1 
ENSMUST00020182652.1 Gm55112 ENSMUST00020182652.1 Gm55112 (from geneSymbol) LF199329 uc288xnq.1 uc288xnq.1 
ENSMUST00020182653.1 Gm56260 ENSMUST00020182653.1 Gm56260 (from geneSymbol) LF204989 uc288xnr.1 uc288xnr.1 
ENSMUST00020182654.1 Gm55259 ENSMUST00020182654.1 Gm55259 (from geneSymbol) uc288xns.1 uc288xns.1 
ENSMUST00020182655.1 Gm54498 ENSMUST00020182655.1 Gm54498 (from geneSymbol) uc288xnt.1 uc288xnt.1 
ENSMUST00020182656.1 Gm56072 ENSMUST00020182656.1 Gm56072 (from geneSymbol) LF197358 uc288xnu.1 uc288xnu.1 
ENSMUST00020182657.1 Gm55646 ENSMUST00020182657.1 Gm55646 (from geneSymbol) LF235978 uc288xnv.1 uc288xnv.1 
ENSMUST00020182658.1 Gm54584 ENSMUST00020182658.1 Gm54584 (from geneSymbol) uc288xnw.1 uc288xnw.1 
ENSMUST00020182659.1 Gm55613 ENSMUST00020182659.1 Gm55613 (from geneSymbol) uc288xnx.1 uc288xnx.1 
ENSMUST00020182660.1 Gm55734 ENSMUST00020182660.1 Gm55734 (from geneSymbol) uc288xny.1 uc288xny.1 
ENSMUST00020182661.1 Gm54421 ENSMUST00020182661.1 Gm54421 (from geneSymbol) uc288xnz.1 uc288xnz.1 
ENSMUST00020182662.1 Gm55748 ENSMUST00020182662.1 Gm55748 (from geneSymbol) uc288xoa.1 uc288xoa.1 
ENSMUST00020182663.1 Gm56065 ENSMUST00020182663.1 Gm56065 (from geneSymbol) uc288xob.1 uc288xob.1 
ENSMUST00020182664.1 Gm56086 ENSMUST00020182664.1 Gm56086 (from geneSymbol) uc288xoc.1 uc288xoc.1 
ENSMUST00020182665.1 Gm55840 ENSMUST00020182665.1 Gm55840 (from geneSymbol) uc288xod.1 uc288xod.1 
ENSMUST00020182666.1 Gm55360 ENSMUST00020182666.1 Gm55360 (from geneSymbol) AK014762 uc288xoe.1 uc288xoe.1 
ENSMUST00020182667.1 Gm55650 ENSMUST00020182667.1 Gm55650 (from geneSymbol) uc288xof.1 uc288xof.1 
ENSMUST00020182668.1 Gm55763 ENSMUST00020182668.1 Gm55763 (from geneSymbol) uc288xog.1 uc288xog.1 
ENSMUST00020182669.1 Gm56055 ENSMUST00020182669.1 Gm56055 (from geneSymbol) AB350056 uc288xoh.1 uc288xoh.1 
ENSMUST00020182670.1 Gm54491 ENSMUST00020182670.1 Gm54491 (from geneSymbol) uc288xoi.1 uc288xoi.1 
ENSMUST00020182671.1 Gm55364 ENSMUST00020182671.1 Gm55364 (from geneSymbol) uc288xoj.1 uc288xoj.1 
ENSMUST00020182672.1 Gm54413 ENSMUST00020182672.1 Gm54413 (from geneSymbol) uc288xok.1 uc288xok.1 
ENSMUST00020182673.1 Gm55754 ENSMUST00020182673.1 Gm55754 (from geneSymbol) uc288xol.1 uc288xol.1 
ENSMUST00020182674.1 Gm56429 ENSMUST00020182674.1 Gm56429 (from geneSymbol) LF192526 uc288xom.1 uc288xom.1 
ENSMUST00020182675.1 Gm54600 ENSMUST00020182675.1 Gm54600 (from geneSymbol) uc288xon.1 uc288xon.1 
ENSMUST00020182676.1 Gm54345 ENSMUST00020182676.1 Gm54345 (from geneSymbol) uc288xoo.1 uc288xoo.1 
ENSMUST00020182677.1 Gm56123 ENSMUST00020182677.1 Gm56123 (from geneSymbol) uc288xop.1 uc288xop.1 
ENSMUST00020182678.1 Gm55812 ENSMUST00020182678.1 Gm55812 (from geneSymbol) LF197035 uc288xoq.1 uc288xoq.1 
ENSMUST00020182679.1 Gm54696 ENSMUST00020182679.1 Gm54696 (from geneSymbol) uc288xor.1 uc288xor.1 
ENSMUST00020182680.1 Gm55573 ENSMUST00020182680.1 Gm55573 (from geneSymbol) uc288xos.1 uc288xos.1 
ENSMUST00020182681.1 Gm55587 ENSMUST00020182681.1 Gm55587 (from geneSymbol) KJ440524 uc288xot.1 uc288xot.1 
ENSMUST00020182682.1 Gm54476 ENSMUST00020182682.1 Gm54476 (from geneSymbol) uc288xou.1 uc288xou.1 
ENSMUST00020182683.1 Gm56280 ENSMUST00020182683.1 Gm56280 (from geneSymbol) uc288xov.1 uc288xov.1 
ENSMUST00020182684.1 Gm55637 ENSMUST00020182684.1 Gm55637 (from geneSymbol) uc288xow.1 uc288xow.1 
ENSMUST00020182685.1 Gm55749 ENSMUST00020182685.1 Gm55749 (from geneSymbol) uc288xox.1 uc288xox.1 
ENSMUST00020182686.1 Gm56402 ENSMUST00020182686.1 Gm56402 (from geneSymbol) uc288xoy.1 uc288xoy.1 
ENSMUST00020182687.1 Gm56244 ENSMUST00020182687.1 Gm56244 (from geneSymbol) uc288xoz.1 uc288xoz.1 
ENSMUST00020182688.1 Gm55497 ENSMUST00020182688.1 Gm55497 (from geneSymbol) DQ543817 uc288xpa.1 uc288xpa.1 
ENSMUST00020182689.1 Gm56221 ENSMUST00020182689.1 Gm56221 (from geneSymbol) uc288xpb.1 uc288xpb.1 
ENSMUST00020182690.1 Gm54791 ENSMUST00020182690.1 Gm54791 (from geneSymbol) uc288xpc.1 uc288xpc.1 
ENSMUST00020182691.1 Gm55107 ENSMUST00020182691.1 Gm55107 (from geneSymbol) LF192537 uc288xpd.1 uc288xpd.1 
ENSMUST00020182692.1 Gm55051 ENSMUST00020182692.1 Gm55051 (from geneSymbol) uc288xpe.1 uc288xpe.1 
ENSMUST00020182693.1 Gm54586 ENSMUST00020182693.1 Gm54586 (from geneSymbol) uc288xpf.1 uc288xpf.1 
ENSMUST00020182694.1 Gm55032 ENSMUST00020182694.1 Gm55032 (from geneSymbol) uc288xpg.1 uc288xpg.1 
ENSMUST00020182695.1 Gm55253 ENSMUST00020182695.1 Gm55253 (from geneSymbol) uc288xph.1 uc288xph.1 
ENSMUST00020182696.1 Gm54567 ENSMUST00020182696.1 Gm54567 (from geneSymbol) uc288xpi.1 uc288xpi.1 
ENSMUST00020182697.1 Gm55285 ENSMUST00020182697.1 Gm55285 (from geneSymbol) uc288xpj.1 uc288xpj.1 
ENSMUST00020182698.1 Gm56185 ENSMUST00020182698.1 Gm56185 (from geneSymbol) uc288xpk.1 uc288xpk.1 
ENSMUST00020182699.1 Gm56190 ENSMUST00020182699.1 Gm56190 (from geneSymbol) DM175261 uc288xpl.1 uc288xpl.1 
ENSMUST00020182700.1 Gm54652 ENSMUST00020182700.1 Gm54652 (from geneSymbol) uc288xpm.1 uc288xpm.1 
ENSMUST00020182701.1 Gm55929 ENSMUST00020182701.1 Gm55929 (from geneSymbol) DQ311494 uc288xpn.1 uc288xpn.1 
ENSMUST00020182702.1 Gm54489 ENSMUST00020182702.1 Gm54489 (from geneSymbol) uc288xpo.1 uc288xpo.1 
ENSMUST00020182703.1 Gm54656 ENSMUST00020182703.1 Gm54656 (from geneSymbol) uc288xpp.1 uc288xpp.1 
ENSMUST00020182704.1 Gm54591 ENSMUST00020182704.1 Gm54591 (from geneSymbol) uc288xpq.1 uc288xpq.1 
ENSMUST00020182705.1 Gm56425 ENSMUST00020182705.1 Gm56425 (from geneSymbol) AK049839 uc288xpr.1 uc288xpr.1 
ENSMUST00020182706.1 Gm56479 ENSMUST00020182706.1 Gm56479 (from geneSymbol) uc288xps.1 uc288xps.1 
ENSMUST00020182707.1 Gm55304 ENSMUST00020182707.1 Gm55304 (from geneSymbol) AB352500 uc288xpt.1 uc288xpt.1 
ENSMUST00020182708.1 Gm55376 ENSMUST00020182708.1 Gm55376 (from geneSymbol) uc288xpu.1 uc288xpu.1 
ENSMUST00020182709.1 Gm54583 ENSMUST00020182709.1 Gm54583 (from geneSymbol) uc288xpv.1 uc288xpv.1 
ENSMUST00020182710.1 Gm54681 ENSMUST00020182710.1 Gm54681 (from geneSymbol) uc288xpw.1 uc288xpw.1 
ENSMUST00020182711.1 Gm55127 ENSMUST00020182711.1 Gm55127 (from geneSymbol) uc288xpx.1 uc288xpx.1 
ENSMUST00020182712.1 Gm54551 ENSMUST00020182712.1 Gm54551 (from geneSymbol) AB352500 uc288xpy.1 uc288xpy.1 
ENSMUST00020182713.1 Gm55391 ENSMUST00020182713.1 Gm55391 (from geneSymbol) uc288xpz.1 uc288xpz.1 
ENSMUST00020182714.1 Gm55950 ENSMUST00020182714.1 Gm55950 (from geneSymbol) uc288xqa.1 uc288xqa.1 
ENSMUST00020182715.1 Gm55682 ENSMUST00020182715.1 Gm55682 (from geneSymbol) uc288xqb.1 uc288xqb.1 
ENSMUST00020182716.1 Gm55121 ENSMUST00020182716.1 Gm55121 (from geneSymbol) uc288xqc.1 uc288xqc.1 
ENSMUST00020182717.1 Gm24826 ENSMUST00020182717.1 Gm24826 (from geneSymbol) uc288xqd.1 uc288xqd.1 
ENSMUST00020182718.1 Gm56251 ENSMUST00020182718.1 Gm56251 (from geneSymbol) uc288xqe.1 uc288xqe.1 
ENSMUST00020182719.1 Gm55933 ENSMUST00020182719.1 Gm55933 (from geneSymbol) BC152802 uc288xqf.1 uc288xqf.1 
ENSMUST00020182720.1 Gm55883 ENSMUST00020182720.1 Gm55883 (from geneSymbol) uc288xqg.1 uc288xqg.1 
ENSMUST00020182721.1 Gm54813 ENSMUST00020182721.1 Gm54813 (from geneSymbol) uc288xqh.1 uc288xqh.1 
ENSMUST00020182722.1 Gm54360 ENSMUST00020182722.1 Gm54360 (from geneSymbol) uc288xqi.1 uc288xqi.1 
ENSMUST00020182723.1 Gm56057 ENSMUST00020182723.1 Gm56057 (from geneSymbol) uc288xqj.1 uc288xqj.1 
ENSMUST00020182724.1 Gm55743 ENSMUST00020182724.1 Gm55743 (from geneSymbol) uc288xqk.1 uc288xqk.1 
ENSMUST00020182725.1 Gm55583 ENSMUST00020182725.1 Gm55583 (from geneSymbol) uc288xql.1 uc288xql.1 
ENSMUST00020182726.1 Gm22897 ENSMUST00020182726.1 Gm22897 (from geneSymbol) uc288xqm.1 uc288xqm.1 
ENSMUST00020182727.1 Gm55267 ENSMUST00020182727.1 Gm55267 (from geneSymbol) uc288xqn.1 uc288xqn.1 
ENSMUST00020182728.1 Gm56060 ENSMUST00020182728.1 Gm56060 (from geneSymbol) uc288xqo.1 uc288xqo.1 
ENSMUST00020182729.1 Gm54669 ENSMUST00020182729.1 Gm54669 (from geneSymbol) uc288xqp.1 uc288xqp.1 
ENSMUST00020182730.1 Gm55405 ENSMUST00020182730.1 Gm55405 (from geneSymbol) uc288xqq.1 uc288xqq.1 
ENSMUST00020182731.1 Gm56052 ENSMUST00020182731.1 Gm56052 (from geneSymbol) uc288xqr.1 uc288xqr.1 
ENSMUST00020182732.1 Gm55538 ENSMUST00020182732.1 Gm55538 (from geneSymbol) uc288xqs.1 uc288xqs.1 
ENSMUST00020182733.1 Gm55065 ENSMUST00020182733.1 Gm55065 (from geneSymbol) LF196819 uc288xqt.1 uc288xqt.1 
ENSMUST00020182734.1 Gm54513 ENSMUST00020182734.1 Gm54513 (from geneSymbol) uc288xqu.1 uc288xqu.1 
ENSMUST00020182735.1 Gm55580 ENSMUST00020182735.1 Gm55580 (from geneSymbol) LF202164 uc288xqv.1 uc288xqv.1 
ENSMUST00020182736.1 Gm56152 ENSMUST00020182736.1 Gm56152 (from geneSymbol) uc288xqw.1 uc288xqw.1 
ENSMUST00020182737.1 Snora19 ENSMUST00020182737.1 Snora19 (from geneSymbol) AF357408 uc288xqx.1 uc288xqx.1 
ENSMUST00020182738.1 Gm55369 ENSMUST00020182738.1 Gm55369 (from geneSymbol) uc288xqy.1 uc288xqy.1 
ENSMUST00020182739.1 Gm54779 ENSMUST00020182739.1 Gm54779 (from geneSymbol) DQ311494 uc288xqz.1 uc288xqz.1 
ENSMUST00020182740.1 Gm55044 ENSMUST00020182740.1 Gm55044 (from geneSymbol) uc288xra.1 uc288xra.1 
ENSMUST00020182741.1 Gm56256 ENSMUST00020182741.1 Gm56256 (from geneSymbol) DQ541194 uc288xrb.1 uc288xrb.1 
ENSMUST00020182742.1 Gm55168 ENSMUST00020182742.1 Gm55168 (from geneSymbol) uc288xrc.1 uc288xrc.1 
ENSMUST00020182743.1 Gm54611 ENSMUST00020182743.1 Gm54611 (from geneSymbol) AK153385 uc288xrd.1 uc288xrd.1 
ENSMUST00020182744.1 Gm55636 ENSMUST00020182744.1 Gm55636 (from geneSymbol) DQ541194 uc288xre.1 uc288xre.1 
ENSMUST00020182745.1 Gm55719 ENSMUST00020182745.1 Gm55719 (from geneSymbol) uc288xrf.1 uc288xrf.1 
ENSMUST00020182746.1 Gm54731 ENSMUST00020182746.1 Gm54731 (from geneSymbol) uc288xrg.1 uc288xrg.1 
ENSMUST00020182747.1 Gm55341 ENSMUST00020182747.1 Gm55341 (from geneSymbol) LF200534 uc288xrh.1 uc288xrh.1 
ENSMUST00020182748.1 Gm54927 ENSMUST00020182748.1 Gm54927 (from geneSymbol) LF196407 uc288xri.1 uc288xri.1 
ENSMUST00020182749.1 Gm54378 ENSMUST00020182749.1 Gm54378 (from geneSymbol) uc288xrj.1 uc288xrj.1 
ENSMUST00020182750.1 Gm54552 ENSMUST00020182750.1 Gm54552 (from geneSymbol) DQ311494 uc288xrk.1 uc288xrk.1 
ENSMUST00020182751.1 Gm54457 ENSMUST00020182751.1 Gm54457 (from geneSymbol) uc288xrl.1 uc288xrl.1 
ENSMUST00020182752.1 Gm55452 ENSMUST00020182752.1 Gm55452 (from geneSymbol) uc288xrm.1 uc288xrm.1 
ENSMUST00020182753.1 Gm55225 ENSMUST00020182753.1 Gm55225 (from geneSymbol) uc288xrn.1 uc288xrn.1 
ENSMUST00020182754.1 Gm56227 ENSMUST00020182754.1 Gm56227 (from geneSymbol) uc288xro.1 uc288xro.1 
ENSMUST00020182755.1 Gm55730 ENSMUST00020182755.1 Gm55730 (from geneSymbol) uc288xrp.1 uc288xrp.1 
ENSMUST00020182756.1 Gm54518 ENSMUST00020182756.1 Gm54518 (from geneSymbol) LF235975 uc288xrq.1 uc288xrq.1 
ENSMUST00020182757.1 Gm55203 ENSMUST00020182757.1 Gm55203 (from geneSymbol) uc288xrr.1 uc288xrr.1 
ENSMUST00020182758.1 Snord3b1 ENSMUST00020182758.1 Snord3b1 (from geneSymbol) AK019039 uc288xrs.1 uc288xrs.1 
ENSMUST00020182759.1 Gm56391 ENSMUST00020182759.1 Gm56391 (from geneSymbol) uc288xrt.1 uc288xrt.1 
ENSMUST00020182760.1 Gm55643 ENSMUST00020182760.1 Gm55643 (from geneSymbol) LF235975 uc288xru.1 uc288xru.1 
ENSMUST00020182761.1 Gm55597 ENSMUST00020182761.1 Gm55597 (from geneSymbol) uc288xrv.1 uc288xrv.1 
ENSMUST00020182762.1 Gm56097 ENSMUST00020182762.1 Gm56097 (from geneSymbol) uc288xrw.1 uc288xrw.1 
ENSMUST00020182763.1 Gm55268 ENSMUST00020182763.1 Gm55268 (from geneSymbol) uc288xrx.1 uc288xrx.1 
ENSMUST00020182764.1 Gm55619 ENSMUST00020182764.1 Gm55619 (from geneSymbol) uc288xry.1 uc288xry.1 
ENSMUST00020182765.1 Gm55713 ENSMUST00020182765.1 Gm55713 (from geneSymbol) uc288xrz.1 uc288xrz.1 
ENSMUST00020182766.1 Gm55440 ENSMUST00020182766.1 Gm55440 (from geneSymbol) uc288xsa.1 uc288xsa.1 
ENSMUST00020182767.1 Gm55768 ENSMUST00020182767.1 Gm55768 (from geneSymbol) uc288xsb.1 uc288xsb.1 
ENSMUST00020182768.1 Gm55937 ENSMUST00020182768.1 Gm55937 (from geneSymbol) LF201096 uc288xsc.1 uc288xsc.1 
ENSMUST00020182769.1 Gm56242 ENSMUST00020182769.1 Gm56242 (from geneSymbol) uc288xsd.1 uc288xsd.1 
ENSMUST00020182770.1 Gm55539 ENSMUST00020182770.1 Gm55539 (from geneSymbol) uc288xse.1 uc288xse.1 
ENSMUST00020182771.1 Gm56131 ENSMUST00020182771.1 Gm56131 (from geneSymbol) uc288xsf.1 uc288xsf.1 
ENSMUST00020182772.1 Gm56049 ENSMUST00020182772.1 Gm56049 (from geneSymbol) BC068288 uc288xsg.1 uc288xsg.1 
ENSMUST00020182773.1 Gm55641 ENSMUST00020182773.1 Gm55641 (from geneSymbol) uc288xsh.1 uc288xsh.1 
ENSMUST00020182774.1 Gm54582 ENSMUST00020182774.1 Gm54582 (from geneSymbol) uc288xsi.1 uc288xsi.1 
ENSMUST00020182775.1 Gm55535 ENSMUST00020182775.1 Gm55535 (from geneSymbol) uc288xsj.1 uc288xsj.1 
ENSMUST00020182776.1 Gm55912 ENSMUST00020182776.1 Gm55912 (from geneSymbol) LF201029 uc288xsk.1 uc288xsk.1 
ENSMUST00020182777.1 Gm54465 ENSMUST00020182777.1 Gm54465 (from geneSymbol) uc288xsl.1 uc288xsl.1 
ENSMUST00020182778.1 Gm54444 ENSMUST00020182778.1 Gm54444 (from geneSymbol) uc288xsm.1 uc288xsm.1 
ENSMUST00020182779.1 Gm56254 ENSMUST00020182779.1 Gm56254 (from geneSymbol) uc288xsn.1 uc288xsn.1 
ENSMUST00020182780.1 Gm54554 ENSMUST00020182780.1 Gm54554 (from geneSymbol) uc288xso.1 uc288xso.1 
ENSMUST00020182781.1 Gm55871 ENSMUST00020182781.1 Gm55871 (from geneSymbol) uc288xsp.1 uc288xsp.1 
ENSMUST00020182782.1 Gm56098 ENSMUST00020182782.1 Gm56098 (from geneSymbol) uc288xsq.1 uc288xsq.1 
ENSMUST00020182783.1 Gm54364 ENSMUST00020182783.1 Gm54364 (from geneSymbol) uc288xsr.1 uc288xsr.1 
ENSMUST00020182784.1 Gm56478 ENSMUST00020182784.1 Gm56478 (from geneSymbol) uc288xss.1 uc288xss.1 
ENSMUST00020182785.1 Gm56370 ENSMUST00020182785.1 Gm56370 (from geneSymbol) uc288xst.1 uc288xst.1 
ENSMUST00020182786.1 Gm54346 ENSMUST00020182786.1 Gm54346 (from geneSymbol) uc288xsu.1 uc288xsu.1 
ENSMUST00020182787.1 Snord33 ENSMUST00020182787.1 small nucleolar RNA, C/D box 33 (from RefSeq NR_001277.2) NR_001277 uc288xsv.1 uc288xsv.1 
ENSMUST00020182788.1 Gm56348 ENSMUST00020182788.1 Gm56348 (from geneSymbol) uc288xsw.1 uc288xsw.1 
ENSMUST00020182789.1 Gm55948 ENSMUST00020182789.1 Gm55948 (from geneSymbol) DQ311494 uc288xsx.1 uc288xsx.1 
ENSMUST00020182790.1 Gm55219 ENSMUST00020182790.1 Gm55219 (from geneSymbol) uc288xsy.1 uc288xsy.1 
ENSMUST00020182791.1 Gm55524 ENSMUST00020182791.1 Gm55524 (from geneSymbol) AK033579 uc288xsz.1 uc288xsz.1 
ENSMUST00020182792.1 Gm54967 ENSMUST00020182792.1 Gm54967 (from geneSymbol) uc288xta.1 uc288xta.1 
ENSMUST00020182793.1 Gm55586 ENSMUST00020182793.1 Gm55586 (from geneSymbol) LF202177 uc288xtb.1 uc288xtb.1 
ENSMUST00020182794.1 Gm55286 ENSMUST00020182794.1 Gm55286 (from geneSymbol) uc288xtc.1 uc288xtc.1 
ENSMUST00020182795.1 Gm55494 ENSMUST00020182795.1 Gm55494 (from geneSymbol) uc288xtd.1 uc288xtd.1 
ENSMUST00020182796.1 Gm55821 ENSMUST00020182796.1 Gm55821 (from geneSymbol) uc288xte.1 uc288xte.1 
ENSMUST00020182797.1 Gm56421 ENSMUST00020182797.1 Gm56421 (from geneSymbol) LF196711 uc288xtf.1 uc288xtf.1 
ENSMUST00020182798.1 Gm55714 ENSMUST00020182798.1 Gm55714 (from geneSymbol) uc288xtg.1 uc288xtg.1 
ENSMUST00020182799.1 Gm54805 ENSMUST00020182799.1 Gm54805 (from geneSymbol) uc288xth.1 uc288xth.1 
ENSMUST00020182800.1 Gm55460 ENSMUST00020182800.1 Gm55460 (from geneSymbol) uc288xti.1 uc288xti.1 
ENSMUST00020182801.1 Gm56312 ENSMUST00020182801.1 Gm56312 (from geneSymbol) uc288xtj.1 uc288xtj.1 
ENSMUST00020182802.1 Gm54933 ENSMUST00020182802.1 Gm54933 (from geneSymbol) uc288xtk.1 uc288xtk.1 
ENSMUST00020182803.1 Gm55215 ENSMUST00020182803.1 Gm55215 (from geneSymbol) uc288xtl.1 uc288xtl.1 
ENSMUST00020182804.1 Gm55931 ENSMUST00020182804.1 Gm55931 (from geneSymbol) uc288xtm.1 uc288xtm.1 
ENSMUST00020182805.1 Gm55069 ENSMUST00020182805.1 Gm55069 (from geneSymbol) uc288xtn.1 uc288xtn.1 
ENSMUST00020182806.1 Gm55954 ENSMUST00020182806.1 Gm55954 (from geneSymbol) uc288xto.1 uc288xto.1 
ENSMUST00020182807.1 Gm55724 ENSMUST00020182807.1 Gm55724 (from geneSymbol) uc288xtp.1 uc288xtp.1 
ENSMUST00020182808.1 Gm54631 ENSMUST00020182808.1 Gm54631 (from geneSymbol) uc288xtq.1 uc288xtq.1 
ENSMUST00020182809.1 Gm55856 ENSMUST00020182809.1 Gm55856 (from geneSymbol) uc288xtr.1 uc288xtr.1 
ENSMUST00020182810.1 Gm55495 ENSMUST00020182810.1 Gm55495 (from geneSymbol) LF197434 uc288xts.1 uc288xts.1 
ENSMUST00020182811.1 Gm55926 ENSMUST00020182811.1 Gm55926 (from geneSymbol) uc288xtt.1 uc288xtt.1 
ENSMUST00020182812.1 Gm55423 ENSMUST00020182812.1 Gm55423 (from geneSymbol) LF269146 uc288xtu.1 uc288xtu.1 
ENSMUST00020182813.1 Gm54781 ENSMUST00020182813.1 Gm54781 (from geneSymbol) uc288xtv.1 uc288xtv.1 
ENSMUST00020182814.1 Gm55110 ENSMUST00020182814.1 Gm55110 (from geneSymbol) AK049674 uc288xtw.1 uc288xtw.1 
ENSMUST00020182815.1 Gm55715 ENSMUST00020182815.1 Gm55715 (from geneSymbol) uc288xtx.1 uc288xtx.1 
ENSMUST00020182816.1 Gm55428 ENSMUST00020182816.1 Gm55428 (from geneSymbol) uc288xty.1 uc288xty.1 
ENSMUST00020182817.1 Gm55404 ENSMUST00020182817.1 Gm55404 (from geneSymbol) uc288xtz.1 uc288xtz.1 
ENSMUST00020182818.1 Gm56261 ENSMUST00020182818.1 Gm56261 (from geneSymbol) uc288xua.1 uc288xua.1 
ENSMUST00020182819.1 Gm56005 ENSMUST00020182819.1 Gm56005 (from geneSymbol) uc288xub.1 uc288xub.1 
ENSMUST00020182820.1 Gm56457 ENSMUST00020182820.1 Gm56457 (from geneSymbol) LF193813 uc288xuc.1 uc288xuc.1 
ENSMUST00020182821.1 Gm56384 ENSMUST00020182821.1 Gm56384 (from geneSymbol) uc288xud.1 uc288xud.1 
ENSMUST00020182822.1 Gm56454 ENSMUST00020182822.1 Gm56454 (from geneSymbol) uc288xue.1 uc288xue.1 
ENSMUST00020182823.1 Gm56278 ENSMUST00020182823.1 Gm56278 (from geneSymbol) uc288xuf.1 uc288xuf.1 
ENSMUST00020182824.1 Gm55839 ENSMUST00020182824.1 Gm55839 (from geneSymbol) uc288xug.1 uc288xug.1 
ENSMUST00020182825.1 Gm55179 ENSMUST00020182825.1 Gm55179 (from geneSymbol) DQ311494 uc288xuh.1 uc288xuh.1 
ENSMUST00020182826.1 Gm56000 ENSMUST00020182826.1 Gm56000 (from geneSymbol) uc288xui.1 uc288xui.1 
ENSMUST00020182827.1 Gm55504 ENSMUST00020182827.1 Gm55504 (from geneSymbol) uc288xuj.1 uc288xuj.1 
ENSMUST00020182828.1 Gm25716 ENSMUST00020182828.1 Gm25716 (from geneSymbol) LF200006 uc288xuk.1 uc288xuk.1 
ENSMUST00020182829.1 Gm54902 ENSMUST00020182829.1 Gm54902 (from geneSymbol) uc288xul.1 uc288xul.1 
ENSMUST00020182830.1 Gm55990 ENSMUST00020182830.1 Gm55990 (from geneSymbol) uc288xum.1 uc288xum.1 
ENSMUST00020182831.1 Gm56024 ENSMUST00020182831.1 Gm56024 (from geneSymbol) uc288xun.1 uc288xun.1 
ENSMUST00020182832.1 Gm56236 ENSMUST00020182832.1 Gm56236 (from geneSymbol) uc288xuo.1 uc288xuo.1 
ENSMUST00020182833.1 Gm56233 ENSMUST00020182833.1 Gm56233 (from geneSymbol) uc288xup.1 uc288xup.1 
ENSMUST00020182834.1 Gm54858 ENSMUST00020182834.1 Gm54858 (from geneSymbol) uc288xuq.1 uc288xuq.1 
ENSMUST00020182835.1 Gm54826 ENSMUST00020182835.1 Gm54826 (from geneSymbol) uc288xur.1 uc288xur.1 
ENSMUST00020182836.1 Gm54848 ENSMUST00020182836.1 Gm54848 (from geneSymbol) uc288xus.1 uc288xus.1 
ENSMUST00020182837.1 Gm55627 ENSMUST00020182837.1 Gm55627 (from geneSymbol) uc288xut.1 uc288xut.1 
ENSMUST00020182838.1 Gm56333 ENSMUST00020182838.1 Gm56333 (from geneSymbol) uc288xuu.1 uc288xuu.1 
ENSMUST00020182839.1 Gm55367 ENSMUST00020182839.1 Gm55367 (from geneSymbol) uc288xuv.1 uc288xuv.1 
ENSMUST00020182840.1 Gm55704 ENSMUST00020182840.1 Gm55704 (from geneSymbol) uc288xuw.1 uc288xuw.1 
ENSMUST00020182841.1 Gm55862 ENSMUST00020182841.1 Gm55862 (from geneSymbol) uc288xux.1 uc288xux.1 
ENSMUST00020182842.1 Gm55483 ENSMUST00020182842.1 Gm55483 (from geneSymbol) uc288xuy.1 uc288xuy.1 
ENSMUST00020182843.1 Gm54487 ENSMUST00020182843.1 Gm54487 (from geneSymbol) uc288xuz.1 uc288xuz.1 
ENSMUST00020182844.1 Gm55232 ENSMUST00020182844.1 Gm55232 (from geneSymbol) uc288xva.1 uc288xva.1 
ENSMUST00020182845.1 Gm55694 ENSMUST00020182845.1 Gm55694 (from geneSymbol) uc288xvb.1 uc288xvb.1 
ENSMUST00020182846.1 Gm55572 ENSMUST00020182846.1 Gm55572 (from geneSymbol) AB351420 uc288xvc.1 uc288xvc.1 
ENSMUST00020182847.1 Gm55716 ENSMUST00020182847.1 Gm55716 (from geneSymbol) uc288xvd.1 uc288xvd.1 
ENSMUST00020182848.1 Gm54469 ENSMUST00020182848.1 Gm54469 (from geneSymbol) uc288xve.1 uc288xve.1 
ENSMUST00020182849.1 Gm55780 ENSMUST00020182849.1 Gm55780 (from geneSymbol) uc288xvf.1 uc288xvf.1 
ENSMUST00020182850.1 Gm55547 ENSMUST00020182850.1 Gm55547 (from geneSymbol) uc288xvg.1 uc288xvg.1 
ENSMUST00020182851.1 Gm55153 ENSMUST00020182851.1 Gm55153 (from geneSymbol) uc288xvh.1 uc288xvh.1 
ENSMUST00020182852.1 Gm55216 ENSMUST00020182852.1 Gm55216 (from geneSymbol) uc288xvi.1 uc288xvi.1 
ENSMUST00020182853.1 Gm54526 ENSMUST00020182853.1 Gm54526 (from geneSymbol) uc288xvj.1 uc288xvj.1 
ENSMUST00020182854.1 Gm54466 ENSMUST00020182854.1 Gm54466 (from geneSymbol) uc288xvk.1 uc288xvk.1 
ENSMUST00020182855.1 Gm56036 ENSMUST00020182855.1 Gm56036 (from geneSymbol) uc288xvl.1 uc288xvl.1 
ENSMUST00020182856.1 Gm55145 ENSMUST00020182856.1 Gm55145 (from geneSymbol) uc288xvm.1 uc288xvm.1 
ENSMUST00020182857.1 Gm56230 ENSMUST00020182857.1 Gm56230 (from geneSymbol) uc288xvn.1 uc288xvn.1 
ENSMUST00020182858.1 Gm55276 ENSMUST00020182858.1 Gm55276 (from geneSymbol) uc288xvo.1 uc288xvo.1 
ENSMUST00020182859.1 Gm54982 ENSMUST00020182859.1 Gm54982 (from geneSymbol) uc288xvp.1 uc288xvp.1 
ENSMUST00020182860.1 Gm55072 ENSMUST00020182860.1 Gm55072 (from geneSymbol) uc288xvq.1 uc288xvq.1 
ENSMUST00020182861.1 Gm56325 ENSMUST00020182861.1 Gm56325 (from geneSymbol) LF290101 uc288xvr.1 uc288xvr.1 
ENSMUST00020182862.1 Gm55916 ENSMUST00020182862.1 Gm55916 (from geneSymbol) uc288xvs.1 uc288xvs.1 
ENSMUST00020182863.1 Gm54393 ENSMUST00020182863.1 Gm54393 (from geneSymbol) uc288xvt.1 uc288xvt.1 
ENSMUST00020182864.1 Gm56171 ENSMUST00020182864.1 Gm56171 (from geneSymbol) uc288xvu.1 uc288xvu.1 
ENSMUST00020182865.1 Gm55683 ENSMUST00020182865.1 Gm55683 (from geneSymbol) uc288xvv.1 uc288xvv.1 
ENSMUST00020182866.1 Gm54434 ENSMUST00020182866.1 Gm54434 (from geneSymbol) AB352541 uc288xvw.1 uc288xvw.1 
ENSMUST00020182867.1 Gm54760 ENSMUST00020182867.1 Gm54760 (from geneSymbol) uc288xvx.1 uc288xvx.1 
ENSMUST00020182868.1 Gm56480 ENSMUST00020182868.1 Gm56480 (from geneSymbol) uc288xvy.1 uc288xvy.1 
ENSMUST00020182869.1 Gm55707 ENSMUST00020182869.1 Gm55707 (from geneSymbol) uc288xvz.1 uc288xvz.1 
ENSMUST00020182870.1 Gm54509 ENSMUST00020182870.1 Gm54509 (from geneSymbol) AF357386 uc288xwa.1 uc288xwa.1 
ENSMUST00020182871.1 Gm55034 ENSMUST00020182871.1 Gm55034 (from geneSymbol) uc288xwb.1 uc288xwb.1 
ENSMUST00020182872.1 Gm54767 ENSMUST00020182872.1 Gm54767 (from geneSymbol) uc288xwc.1 uc288xwc.1 
ENSMUST00020182873.1 Gm55048 ENSMUST00020182873.1 Gm55048 (from geneSymbol) uc288xwd.1 uc288xwd.1 
ENSMUST00020182874.1 Gm55033 ENSMUST00020182874.1 Gm55033 (from geneSymbol) uc288xwe.1 uc288xwe.1 
ENSMUST00020182875.1 Gm55035 ENSMUST00020182875.1 Gm55035 (from geneSymbol) uc288xwf.1 uc288xwf.1 
ENSMUST00020182876.1 Gm56046 ENSMUST00020182876.1 Gm56046 (from geneSymbol) uc288xwg.1 uc288xwg.1 
ENSMUST00020182877.1 Gm55071 ENSMUST00020182877.1 Gm55071 (from geneSymbol) uc288xwh.1 uc288xwh.1 
ENSMUST00020182878.1 Gm55464 ENSMUST00020182878.1 Gm55464 (from geneSymbol) uc288xwi.1 uc288xwi.1 
ENSMUST00020182879.1 Gm55212 ENSMUST00020182879.1 Gm55212 (from geneSymbol) uc288xwj.1 uc288xwj.1 
ENSMUST00020182880.1 Gm54984 ENSMUST00020182880.1 Gm54984 (from geneSymbol) uc288xwk.1 uc288xwk.1 
ENSMUST00020182881.1 Gm56120 ENSMUST00020182881.1 Gm56120 (from geneSymbol) uc288xwl.1 uc288xwl.1 
ENSMUST00020182882.1 Gm55752 ENSMUST00020182882.1 Gm55752 (from geneSymbol) uc288xwm.1 uc288xwm.1 
ENSMUST00020182883.1 Gm55876 ENSMUST00020182883.1 Gm55876 (from geneSymbol) uc288xwn.1 uc288xwn.1 
ENSMUST00020182884.1 Gm55544 ENSMUST00020182884.1 Gm55544 (from geneSymbol) uc288xwo.1 uc288xwo.1 
ENSMUST00020182885.1 Gm54419 ENSMUST00020182885.1 Gm54419 (from geneSymbol) uc288xwp.1 uc288xwp.1 
ENSMUST00020182886.1 Gm55007 ENSMUST00020182886.1 Gm55007 (from geneSymbol) uc288xwq.1 uc288xwq.1 
ENSMUST00020182887.1 Gm55797 ENSMUST00020182887.1 Gm55797 (from geneSymbol) uc288xwr.1 uc288xwr.1 
ENSMUST00020182888.1 Gm55823 ENSMUST00020182888.1 Gm55823 (from geneSymbol) DQ541194 uc288xws.1 uc288xws.1 
ENSMUST00020182889.1 Gm54568 ENSMUST00020182889.1 Gm54568 (from geneSymbol) uc288xwt.1 uc288xwt.1 
ENSMUST00020182890.1 Gm54354 ENSMUST00020182890.1 Gm54354 (from geneSymbol) DQ541194 uc288xwu.1 uc288xwu.1 
ENSMUST00020182891.1 Gm54761 ENSMUST00020182891.1 Gm54761 (from geneSymbol) uc288xwv.1 uc288xwv.1 
ENSMUST00020182892.1 Gm55818 ENSMUST00020182892.1 Gm55818 (from geneSymbol) uc288xww.1 uc288xww.1 
ENSMUST00020182893.1 Gm55447 ENSMUST00020182893.1 Gm55447 (from geneSymbol) DQ311494 uc288xwx.1 uc288xwx.1 
ENSMUST00020182894.1 Gm55971 ENSMUST00020182894.1 Gm55971 (from geneSymbol) uc288xwy.1 uc288xwy.1 
ENSMUST00020182895.1 Gm54765 ENSMUST00020182895.1 Gm54765 (from geneSymbol) uc288xwz.1 uc288xwz.1 
ENSMUST00020182896.1 Gm54524 ENSMUST00020182896.1 Gm54524 (from geneSymbol) uc288xxa.1 uc288xxa.1 
ENSMUST00020182897.1 Gm55939 ENSMUST00020182897.1 Gm55939 (from geneSymbol) uc288xxb.1 uc288xxb.1 
ENSMUST00020182898.1 Gm55966 ENSMUST00020182898.1 Gm55966 (from geneSymbol) uc288xxc.1 uc288xxc.1 
ENSMUST00020182899.1 Gm55930 ENSMUST00020182899.1 Gm55930 (from geneSymbol) DQ311494 uc288xxd.1 uc288xxd.1 
ENSMUST00020182900.1 Gm56112 ENSMUST00020182900.1 Gm56112 (from geneSymbol) uc288xxe.1 uc288xxe.1 
ENSMUST00020182901.1 Gm54965 ENSMUST00020182901.1 Gm54965 (from geneSymbol) uc288xxf.1 uc288xxf.1 
ENSMUST00020182902.1 Gm55555 ENSMUST00020182902.1 Gm55555 (from geneSymbol) uc288xxg.1 uc288xxg.1 
ENSMUST00020182903.1 Gm56137 ENSMUST00020182903.1 Gm56137 (from geneSymbol) uc288xxh.1 uc288xxh.1 
ENSMUST00020182904.1 Gm55726 ENSMUST00020182904.1 Gm55726 (from geneSymbol) uc288xxi.1 uc288xxi.1 
ENSMUST00020182905.1 Gm55210 ENSMUST00020182905.1 Gm55210 (from geneSymbol) uc288xxj.1 uc288xxj.1 
ENSMUST00020182906.1 Gm55236 ENSMUST00020182906.1 Gm55236 (from geneSymbol) uc288xxk.1 uc288xxk.1 
ENSMUST00020182907.1 Gm54598 ENSMUST00020182907.1 Gm54598 (from geneSymbol) uc288xxl.1 uc288xxl.1 
ENSMUST00020182908.1 Gm54431 ENSMUST00020182908.1 Gm54431 (from geneSymbol) uc288xxm.1 uc288xxm.1 
ENSMUST00020182909.1 Gm54796 ENSMUST00020182909.1 Gm54796 (from geneSymbol) uc288xxn.1 uc288xxn.1 
ENSMUST00020182910.1 Gm56342 ENSMUST00020182910.1 Gm56342 (from geneSymbol) uc288xxo.1 uc288xxo.1 
ENSMUST00020182911.1 Gm56287 ENSMUST00020182911.1 Gm56287 (from geneSymbol) uc288xxp.1 uc288xxp.1 
ENSMUST00020182912.1 Gm54901 ENSMUST00020182912.1 Gm54901 (from geneSymbol) uc288xxq.1 uc288xxq.1 
ENSMUST00020182913.1 Gm56288 ENSMUST00020182913.1 Gm56288 (from geneSymbol) uc288xxr.1 uc288xxr.1 
ENSMUST00020182914.1 Gm54675 ENSMUST00020182914.1 Gm54675 (from geneSymbol) uc288xxs.1 uc288xxs.1 
ENSMUST00020182915.1 Gm54890 ENSMUST00020182915.1 Gm54890 (from geneSymbol) uc288xxt.1 uc288xxt.1 
ENSMUST00020182916.1 Gm56389 ENSMUST00020182916.1 Gm56389 (from geneSymbol) AB352500 uc288xxu.1 uc288xxu.1 
ENSMUST00020182917.1 Gm55415 ENSMUST00020182917.1 Gm55415 (from geneSymbol) uc288xxv.1 uc288xxv.1 
ENSMUST00020182918.1 Gm55891 ENSMUST00020182918.1 Gm55891 (from geneSymbol) uc288xxw.1 uc288xxw.1 
ENSMUST00020182919.1 Gm54428 ENSMUST00020182919.1 Gm54428 (from geneSymbol) LF200274 uc288xxx.1 uc288xxx.1 
ENSMUST00020182920.1 Gm55087 ENSMUST00020182920.1 Gm55087 (from geneSymbol) uc288xxy.1 uc288xxy.1 
ENSMUST00020182921.1 Gm54517 ENSMUST00020182921.1 Gm54517 (from geneSymbol) LF235978 uc288xxz.1 uc288xxz.1 
ENSMUST00020182922.1 Gm56353 ENSMUST00020182922.1 Gm56353 (from geneSymbol) uc288xya.1 uc288xya.1 
ENSMUST00020182923.1 Gm22149 ENSMUST00020182923.1 Gm22149 (from geneSymbol) uc288xyb.1 uc288xyb.1 
ENSMUST00020182924.1 Gm56093 ENSMUST00020182924.1 Gm56093 (from geneSymbol) uc288xyc.1 uc288xyc.1 
ENSMUST00020182925.1 Gm55347 ENSMUST00020182925.1 Gm55347 (from geneSymbol) uc288xyd.1 uc288xyd.1 
ENSMUST00020182926.1 Gm55252 ENSMUST00020182926.1 Gm55252 (from geneSymbol) AB349811 uc288xye.1 uc288xye.1 
ENSMUST00020182927.1 Gm56241 ENSMUST00020182927.1 Gm56241 (from geneSymbol) uc288xyf.1 uc288xyf.1 
ENSMUST00020182928.1 Gm55982 ENSMUST00020182928.1 Gm55982 (from geneSymbol) uc288xyg.1 uc288xyg.1 
ENSMUST00020182929.1 Gm55079 ENSMUST00020182929.1 Gm55079 (from geneSymbol) uc288xyh.1 uc288xyh.1 
ENSMUST00020182930.1 Gm55507 ENSMUST00020182930.1 Gm55507 (from geneSymbol) uc288xyi.1 uc288xyi.1 
ENSMUST00020182931.1 Gm55503 ENSMUST00020182931.1 Gm55503 (from geneSymbol) uc288xyj.1 uc288xyj.1 
ENSMUST00020182932.1 Gm55655 ENSMUST00020182932.1 Gm55655 (from geneSymbol) uc288xyk.1 uc288xyk.1 
ENSMUST00020182933.1 Gm54892 ENSMUST00020182933.1 Gm54892 (from geneSymbol) uc288xyl.1 uc288xyl.1 
ENSMUST00020182934.1 Gm56369 ENSMUST00020182934.1 Gm56369 (from geneSymbol) LF198662 uc288xym.1 uc288xym.1 
ENSMUST00020182935.1 Gm55808 ENSMUST00020182935.1 Gm55808 (from geneSymbol) uc288xyn.1 uc288xyn.1 
ENSMUST00020182936.1 Gm54727 ENSMUST00020182936.1 Gm54727 (from geneSymbol) BC080788 uc288xyo.1 uc288xyo.1 
ENSMUST00020182937.1 Gm54373 ENSMUST00020182937.1 Gm54373 (from geneSymbol) uc288xyp.1 uc288xyp.1 
ENSMUST00020182938.1 Gm56439 ENSMUST00020182938.1 Gm56439 (from geneSymbol) uc288xyq.1 uc288xyq.1 
ENSMUST00020182939.1 Gm55837 ENSMUST00020182939.1 Gm55837 (from geneSymbol) uc288xyr.1 uc288xyr.1 
ENSMUST00020182940.1 Gm56096 ENSMUST00020182940.1 Gm56096 (from geneSymbol) uc288xys.1 uc288xys.1 
ENSMUST00020182941.1 Gm56380 ENSMUST00020182941.1 Gm56380 (from geneSymbol) AB352500 uc288xyt.1 uc288xyt.1 
ENSMUST00020182942.1 Gm56225 ENSMUST00020182942.1 Gm56225 (from geneSymbol) uc288xyu.1 uc288xyu.1 
ENSMUST00020182943.1 Gm54803 ENSMUST00020182943.1 Gm54803 (from geneSymbol) LF243620 uc288xyv.1 uc288xyv.1 
ENSMUST00020182944.1 Gm54366 ENSMUST00020182944.1 Gm54366 (from geneSymbol) uc288xyw.1 uc288xyw.1 
ENSMUST00020182945.1 Gm56076 ENSMUST00020182945.1 Gm56076 (from geneSymbol) uc288xyx.1 uc288xyx.1 
ENSMUST00020182946.1 Gm55867 ENSMUST00020182946.1 Gm55867 (from geneSymbol) uc288xyy.1 uc288xyy.1 
ENSMUST00020182947.1 Gm56330 ENSMUST00020182947.1 Gm56330 (from geneSymbol) uc288xyz.1 uc288xyz.1 
ENSMUST00020182948.1 Gm56382 ENSMUST00020182948.1 Gm56382 (from geneSymbol) uc288xza.1 uc288xza.1 
ENSMUST00020182949.1 Gm56410 ENSMUST00020182949.1 Gm56410 (from geneSymbol) uc288xzb.1 uc288xzb.1 
ENSMUST00020182950.1 Gm55390 ENSMUST00020182950.1 Gm55390 (from geneSymbol) AB351420 uc288xzc.1 uc288xzc.1 
ENSMUST00020182951.1 Gm55434 ENSMUST00020182951.1 Gm55434 (from geneSymbol) DQ311494 uc288xzd.1 uc288xzd.1 
ENSMUST00020182952.1 Gm55395 ENSMUST00020182952.1 Gm55395 (from geneSymbol) uc288xze.1 uc288xze.1 
ENSMUST00020182953.1 Gm56300 ENSMUST00020182953.1 Gm56300 (from geneSymbol) uc288xzf.1 uc288xzf.1 
ENSMUST00020182954.1 Gm55222 ENSMUST00020182954.1 Gm55222 (from geneSymbol) DQ311494 uc288xzg.1 uc288xzg.1 
ENSMUST00020182955.1 Gm55733 ENSMUST00020182955.1 Gm55733 (from geneSymbol) AK132998 uc288xzh.1 uc288xzh.1 
ENSMUST00020182956.1 Gm54918 ENSMUST00020182956.1 Gm54918 (from geneSymbol) uc288xzi.1 uc288xzi.1 
ENSMUST00020182957.1 Gm55984 ENSMUST00020182957.1 Gm55984 (from geneSymbol) uc288xzj.1 uc288xzj.1 
ENSMUST00020182959.1 Gm55042 ENSMUST00020182959.1 Gm55042 (from geneSymbol) uc288xzl.1 uc288xzl.1 
ENSMUST00020182960.1 Gm55502 ENSMUST00020182960.1 Gm55502 (from geneSymbol) uc288xzm.1 uc288xzm.1 
ENSMUST00020182961.1 Gm55711 ENSMUST00020182961.1 Gm55711 (from geneSymbol) uc288xzn.1 uc288xzn.1 
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ENSMUST00020182963.1 Gm56446 ENSMUST00020182963.1 Gm56446 (from geneSymbol) uc288xzp.1 uc288xzp.1 
ENSMUST00020182964.1 Gm54410 ENSMUST00020182964.1 Gm54410 (from geneSymbol) AB352541 uc288xzq.1 uc288xzq.1 
ENSMUST00020182965.1 Gm54558 ENSMUST00020182965.1 Gm54558 (from geneSymbol) uc288xzr.1 uc288xzr.1 
ENSMUST00020182966.1 Gm54864 ENSMUST00020182966.1 Gm54864 (from geneSymbol) uc288xzs.1 uc288xzs.1 
ENSMUST00020182967.1 Gm55183 ENSMUST00020182967.1 Gm55183 (from geneSymbol) uc288xzt.1 uc288xzt.1 
ENSMUST00020182968.1 Gm54925 ENSMUST00020182968.1 Gm54925 (from geneSymbol) uc288xzu.1 uc288xzu.1 
ENSMUST00020182969.1 Gm54350 ENSMUST00020182969.1 Gm54350 (from geneSymbol) DQ311494 uc288xzv.1 uc288xzv.1 
ENSMUST00020182970.1 Gm55863 ENSMUST00020182970.1 Gm55863 (from geneSymbol) uc288xzw.1 uc288xzw.1 
ENSMUST00020182971.1 Gm55652 ENSMUST00020182971.1 Gm55652 (from geneSymbol) uc288xzx.1 uc288xzx.1 
ENSMUST00020182972.1 Gm55049 ENSMUST00020182972.1 Gm55049 (from geneSymbol) uc288xzy.1 uc288xzy.1 
ENSMUST00020182973.1 Gm54818 ENSMUST00020182973.1 Gm54818 (from geneSymbol) LF194832 uc288xzz.1 uc288xzz.1 
ENSMUST00020182974.1 Gm56305 ENSMUST00020182974.1 Gm56305 (from geneSymbol) uc288yaa.1 uc288yaa.1 
ENSMUST00020182975.1 Gm56294 ENSMUST00020182975.1 Gm56294 (from geneSymbol) uc288yab.1 uc288yab.1 
ENSMUST00020182976.1 Gm54703 ENSMUST00020182976.1 Gm54703 (from geneSymbol) uc288yac.1 uc288yac.1 
ENSMUST00020182977.1 Gm54475 ENSMUST00020182977.1 Gm54475 (from geneSymbol) LF199436 uc288yad.1 uc288yad.1 
ENSMUST00020182978.1 Gm56284 ENSMUST00020182978.1 Gm56284 (from geneSymbol) uc288yae.1 uc288yae.1 
ENSMUST00020182979.1 Gm55159 ENSMUST00020182979.1 Gm55159 (from geneSymbol) uc288yaf.1 uc288yaf.1 
ENSMUST00020182980.1 Gm55105 ENSMUST00020182980.1 Gm55105 (from geneSymbol) uc288yag.1 uc288yag.1 
ENSMUST00020182981.1 Gm56121 ENSMUST00020182981.1 Gm56121 (from geneSymbol) uc288yah.1 uc288yah.1 
ENSMUST00020182982.1 Gm55854 ENSMUST00020182982.1 Gm55854 (from geneSymbol) uc288yai.1 uc288yai.1 
ENSMUST00020182983.1 Gm55516 ENSMUST00020182983.1 Gm55516 (from geneSymbol) uc288yaj.1 uc288yaj.1 
ENSMUST00020182984.1 Gm56197 ENSMUST00020182984.1 Gm56197 (from geneSymbol) uc288yak.1 uc288yak.1 
ENSMUST00020182985.1 Gm54906 ENSMUST00020182985.1 Gm54906 (from geneSymbol) uc288yal.1 uc288yal.1 
ENSMUST00020182986.1 Gm54436 ENSMUST00020182986.1 Gm54436 (from geneSymbol) uc288yam.1 uc288yam.1 
ENSMUST00020182987.1 Gm54458 ENSMUST00020182987.1 Gm54458 (from geneSymbol) uc288yan.1 uc288yan.1 
ENSMUST00020182988.1 Gm56059 ENSMUST00020182988.1 Gm56059 (from geneSymbol) uc288yao.1 uc288yao.1 
ENSMUST00020182989.1 Gm55658 ENSMUST00020182989.1 Gm55658 (from geneSymbol) uc288yap.1 uc288yap.1 
ENSMUST00020182990.1 Gm55831 ENSMUST00020182990.1 Gm55831 (from geneSymbol) uc288yaq.1 uc288yaq.1 
ENSMUST00020182991.1 Gm55826 ENSMUST00020182991.1 Gm55826 (from geneSymbol) LF195377 uc288yar.1 uc288yar.1 
ENSMUST00020182992.1 Gm54835 ENSMUST00020182992.1 Gm54835 (from geneSymbol) uc288yas.1 uc288yas.1 
ENSMUST00020182993.1 Gm55576 ENSMUST00020182993.1 Gm55576 (from geneSymbol) uc288yat.1 uc288yat.1 
ENSMUST00020182994.1 Gm54863 ENSMUST00020182994.1 Gm54863 (from geneSymbol) uc288yau.1 uc288yau.1 
ENSMUST00020182995.1 Gm54941 ENSMUST00020182995.1 Gm54941 (from geneSymbol) uc288yav.1 uc288yav.1 
ENSMUST00020182996.1 Gm55666 ENSMUST00020182996.1 Gm55666 (from geneSymbol) uc288yaw.1 uc288yaw.1 
ENSMUST00020182997.1 Gm55370 ENSMUST00020182997.1 Gm55370 (from geneSymbol) uc288yax.1 uc288yax.1 
ENSMUST00020182998.1 Gm56167 ENSMUST00020182998.1 Gm56167 (from geneSymbol) uc288yay.1 uc288yay.1 
ENSMUST00020182999.1 Gm55174 ENSMUST00020182999.1 Gm55174 (from geneSymbol) uc288yaz.1 uc288yaz.1 
ENSMUST00020183000.1 Gm55635 ENSMUST00020183000.1 Gm55635 (from geneSymbol) LF195950 uc288yba.1 uc288yba.1 
ENSMUST00020183001.1 Gm54714 ENSMUST00020183001.1 Gm54714 (from geneSymbol) uc288ybb.1 uc288ybb.1 
ENSMUST00020183002.1 Gm54430 ENSMUST00020183002.1 Gm54430 (from geneSymbol) LF200274 uc288ybc.1 uc288ybc.1 
ENSMUST00020183003.1 Gm54623 ENSMUST00020183003.1 Gm54623 (from geneSymbol) uc288ybd.1 uc288ybd.1 
ENSMUST00020183004.1 Gm56327 ENSMUST00020183004.1 Gm56327 (from geneSymbol) uc288ybe.1 uc288ybe.1 
ENSMUST00020183005.1 Gm56150 ENSMUST00020183005.1 Gm56150 (from geneSymbol) uc288ybf.1 uc288ybf.1 
ENSMUST00020183006.1 Gm54406 ENSMUST00020183006.1 Gm54406 (from geneSymbol) uc288ybg.1 uc288ybg.1 
ENSMUST00020183007.1 Gm54477 ENSMUST00020183007.1 Gm54477 (from geneSymbol) uc288ybh.1 uc288ybh.1 
ENSMUST00020183008.1 Gm54949 ENSMUST00020183008.1 Gm54949 (from geneSymbol) DQ311494 uc288ybi.1 uc288ybi.1 
ENSMUST00020183009.1 Gm55777 ENSMUST00020183009.1 Gm55777 (from geneSymbol) uc288ybj.1 uc288ybj.1 
ENSMUST00020183010.1 Gm54425 ENSMUST00020183010.1 Gm54425 (from geneSymbol) AB352282 uc288ybk.1 uc288ybk.1 
ENSMUST00020183011.1 Gm55884 ENSMUST00020183011.1 Gm55884 (from geneSymbol) uc288ybl.1 uc288ybl.1 
ENSMUST00020183012.1 Gm55552 ENSMUST00020183012.1 Gm55552 (from geneSymbol) uc288ybm.1 uc288ybm.1 
ENSMUST00020183013.1 Gm54897 ENSMUST00020183013.1 Gm54897 (from geneSymbol) uc288ybn.1 uc288ybn.1 
ENSMUST00020183014.1 Gm54819 ENSMUST00020183014.1 Gm54819 (from geneSymbol) LF192645 uc288ybo.1 uc288ybo.1 
ENSMUST00020183015.1 Gm55708 ENSMUST00020183015.1 Gm55708 (from geneSymbol) uc288ybp.1 uc288ybp.1 
ENSMUST00020183016.1 Gm56361 ENSMUST00020183016.1 Gm56361 (from geneSymbol) uc288ybq.1 uc288ybq.1 
ENSMUST00020183017.1 Gm54869 ENSMUST00020183017.1 Gm54869 (from geneSymbol) DQ311494 uc288ybr.1 uc288ybr.1 
ENSMUST00020183018.1 Gm55363 ENSMUST00020183018.1 Gm55363 (from geneSymbol) uc288ybs.1 uc288ybs.1 
ENSMUST00020183019.1 Gm55142 ENSMUST00020183019.1 Gm55142 (from geneSymbol) uc288ybt.1 uc288ybt.1 
ENSMUST00020183020.1 Gm55349 ENSMUST00020183020.1 Gm55349 (from geneSymbol) uc288ybu.1 uc288ybu.1 
ENSMUST00020183021.1 Gm55309 ENSMUST00020183021.1 Gm55309 (from geneSymbol) AB352500 uc288ybv.1 uc288ybv.1 
ENSMUST00020183022.1 Gm55830 ENSMUST00020183022.1 Gm55830 (from geneSymbol) uc288ybw.1 uc288ybw.1 
ENSMUST00020183023.1 Gm54449 ENSMUST00020183023.1 Gm54449 (from geneSymbol) uc288ybx.1 uc288ybx.1 
ENSMUST00020183024.1 Gm54970 ENSMUST00020183024.1 Gm54970 (from geneSymbol) AB349811 uc288yby.1 uc288yby.1 
ENSMUST00020183025.1 Gm55237 ENSMUST00020183025.1 Gm55237 (from geneSymbol) uc288ybz.1 uc288ybz.1 
ENSMUST00020183026.1 Gm54642 ENSMUST00020183026.1 Gm54642 (from geneSymbol) uc288yca.1 uc288yca.1 
ENSMUST00020183027.1 Gm56187 ENSMUST00020183027.1 Gm56187 (from geneSymbol) uc288ycb.1 uc288ycb.1 
ENSMUST00020183028.1 Gm55066 ENSMUST00020183028.1 Gm55066 (from geneSymbol) uc288ycc.1 uc288ycc.1 
ENSMUST00020183029.1 Gm55846 ENSMUST00020183029.1 Gm55846 (from geneSymbol) uc288ycd.1 uc288ycd.1 
ENSMUST00020183030.1 Gm55392 ENSMUST00020183030.1 Gm55392 (from geneSymbol) uc288yce.1 uc288yce.1 
ENSMUST00020183031.1 Gm54845 ENSMUST00020183031.1 Gm54845 (from geneSymbol) uc288ycf.1 uc288ycf.1 
ENSMUST00020183032.1 Gm55465 ENSMUST00020183032.1 Gm55465 (from geneSymbol) uc288ycg.1 uc288ycg.1 
ENSMUST00020183033.1 Gm54768 ENSMUST00020183033.1 Gm54768 (from geneSymbol) LF203975 uc288ych.1 uc288ych.1 
ENSMUST00020183034.1 Gm54349 ENSMUST00020183034.1 Gm54349 (from geneSymbol) DQ311494 uc288yci.1 uc288yci.1 
ENSMUST00020183035.1 Gm55873 ENSMUST00020183035.1 Gm55873 (from geneSymbol) uc288ycj.1 uc288ycj.1 
ENSMUST00020183036.1 Gm54556 ENSMUST00020183036.1 Gm54556 (from geneSymbol) LF199458 uc288yck.1 uc288yck.1 
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ENSMUST00020183038.1 Gm56018 ENSMUST00020183038.1 Gm56018 (from geneSymbol) uc288ycm.1 uc288ycm.1 
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ENSMUST00020183041.1 Gm56132 ENSMUST00020183041.1 Gm56132 (from geneSymbol) LF194409 uc288ycp.1 uc288ycp.1 
ENSMUST00020183042.1 Gm55402 ENSMUST00020183042.1 Gm55402 (from geneSymbol) uc288ycq.1 uc288ycq.1 
ENSMUST00020183043.1 Gm54957 ENSMUST00020183043.1 Gm54957 (from geneSymbol) AB352500 uc288ycr.1 uc288ycr.1 
ENSMUST00020183044.1 Gm55673 ENSMUST00020183044.1 Gm55673 (from geneSymbol) uc288ycs.1 uc288ycs.1 
ENSMUST00020183045.1 Gm54763 ENSMUST00020183045.1 Gm54763 (from geneSymbol) uc288yct.1 uc288yct.1 
ENSMUST00020183046.1 Gm56004 ENSMUST00020183046.1 Gm56004 (from geneSymbol) LF196749 uc288ycu.1 uc288ycu.1 
ENSMUST00020183047.1 Gm55723 ENSMUST00020183047.1 Gm55723 (from geneSymbol) LF139494 uc288ycv.1 uc288ycv.1 
ENSMUST00020183048.1 Gm54478 ENSMUST00020183048.1 Gm54478 (from geneSymbol) uc288ycw.1 uc288ycw.1 
ENSMUST00020183049.1 Gm54745 ENSMUST00020183049.1 Gm54745 (from geneSymbol) uc288ycx.1 uc288ycx.1 
ENSMUST00020183050.1 Gm54401 ENSMUST00020183050.1 Gm54401 (from geneSymbol) uc288ycy.1 uc288ycy.1 
ENSMUST00020183051.1 Gm55456 ENSMUST00020183051.1 Gm55456 (from geneSymbol) uc288ycz.1 uc288ycz.1 
ENSMUST00020183052.1 Gm55054 ENSMUST00020183052.1 Gm55054 (from geneSymbol) uc288yda.1 uc288yda.1 
ENSMUST00020183053.1 Gm54775 ENSMUST00020183053.1 Gm54775 (from geneSymbol) uc288ydb.1 uc288ydb.1 
ENSMUST00020183054.1 Gm54407 ENSMUST00020183054.1 Gm54407 (from geneSymbol) uc288ydc.1 uc288ydc.1 
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ENSMUST00020183056.1 Gm55533 ENSMUST00020183056.1 Gm55533 (from geneSymbol) LF262441 uc288yde.1 uc288yde.1 
ENSMUST00020183057.1 Gm56223 ENSMUST00020183057.1 Gm56223 (from geneSymbol) AB352500 uc288ydf.1 uc288ydf.1 
ENSMUST00020183058.1 Gm55520 ENSMUST00020183058.1 Gm55520 (from geneSymbol) uc288ydg.1 uc288ydg.1 
ENSMUST00020183059.1 Gm54668 ENSMUST00020183059.1 Gm54668 (from geneSymbol) uc288ydh.1 uc288ydh.1 
ENSMUST00020183060.1 Gm56354 ENSMUST00020183060.1 Gm56354 (from geneSymbol) uc288ydi.1 uc288ydi.1 
ENSMUST00020183061.1 Gm55490 ENSMUST00020183061.1 Gm55490 (from geneSymbol) uc288ydj.1 uc288ydj.1 
ENSMUST00020183062.1 Gm54440 ENSMUST00020183062.1 Gm54440 (from geneSymbol) uc288ydk.1 uc288ydk.1 
ENSMUST00020183063.1 Gm54991 ENSMUST00020183063.1 Gm54991 (from geneSymbol) uc288ydl.1 uc288ydl.1 
ENSMUST00020183064.1 Gm55642 ENSMUST00020183064.1 Gm55642 (from geneSymbol) LF199450 uc288ydm.1 uc288ydm.1 
ENSMUST00020183065.1 Gm55761 ENSMUST00020183065.1 Gm55761 (from geneSymbol) uc288ydn.1 uc288ydn.1 
ENSMUST00020183066.1 Gm55478 ENSMUST00020183066.1 Gm55478 (from geneSymbol) uc288ydo.1 uc288ydo.1 
ENSMUST00020183067.1 Gm56099 ENSMUST00020183067.1 Gm56099 (from geneSymbol) uc288ydp.1 uc288ydp.1 
ENSMUST00020183068.1 Gm55548 ENSMUST00020183068.1 Gm55548 (from geneSymbol) LF197750 uc288ydq.1 uc288ydq.1 
ENSMUST00020183069.1 Gm55017 ENSMUST00020183069.1 Gm55017 (from geneSymbol) uc288ydr.1 uc288ydr.1 
ENSMUST00020183070.1 Gm55151 ENSMUST00020183070.1 Gm55151 (from geneSymbol) uc288yds.1 uc288yds.1 
ENSMUST00020183071.1 Gm54960 ENSMUST00020183071.1 Gm54960 (from geneSymbol) uc288ydt.1 uc288ydt.1 
ENSMUST00020183072.1 Gm56237 ENSMUST00020183072.1 Gm56237 (from geneSymbol) uc288ydu.1 uc288ydu.1 
ENSMUST00020183073.1 ENSMUSG00002076890 ENSMUST00020183073.1 ENSMUSG00002076890 (from geneSymbol) uc288ydv.1 uc288ydv.1 
ENSMUST00020183074.1 Gm56318 ENSMUST00020183074.1 Gm56318 (from geneSymbol) uc288ydw.1 uc288ydw.1 
ENSMUST00020183075.1 Gm55140 ENSMUST00020183075.1 Gm55140 (from geneSymbol) uc288ydx.1 uc288ydx.1 
ENSMUST00020183077.1 Gm55674 ENSMUST00020183077.1 Gm55674 (from geneSymbol) DQ311494 uc288ydz.1 uc288ydz.1 
ENSMUST00020183078.1 Gm55413 ENSMUST00020183078.1 Gm55413 (from geneSymbol) uc288yea.1 uc288yea.1 
ENSMUST00020183079.1 Gm55245 ENSMUST00020183079.1 Gm55245 (from geneSymbol) uc288yeb.1 uc288yeb.1 
ENSMUST00020183080.1 Gm55190 ENSMUST00020183080.1 Gm55190 (from geneSymbol) uc288yec.1 uc288yec.1 
ENSMUST00020183081.1 Gm55804 ENSMUST00020183081.1 Gm55804 (from geneSymbol) uc288yed.1 uc288yed.1 
ENSMUST00020183082.1 Gm55293 ENSMUST00020183082.1 Gm55293 (from geneSymbol) uc288yee.1 uc288yee.1 
ENSMUST00020183083.1 Gm55170 ENSMUST00020183083.1 Gm55170 (from geneSymbol) DQ311494 uc288yef.1 uc288yef.1 
ENSMUST00020183084.1 Gm54939 ENSMUST00020183084.1 Gm54939 (from geneSymbol) uc288yeg.1 uc288yeg.1 
ENSMUST00020183085.1 Gm55875 ENSMUST00020183085.1 Gm55875 (from geneSymbol) uc288yeh.1 uc288yeh.1 
ENSMUST00020183086.1 Gm23128 ENSMUST00020183086.1 Gm23128 (from geneSymbol) uc288yei.1 uc288yei.1 
ENSMUST00020183087.1 Gm55645 ENSMUST00020183087.1 Gm55645 (from geneSymbol) uc288yej.1 uc288yej.1 
ENSMUST00020183088.1 Gm56178 ENSMUST00020183088.1 Gm56178 (from geneSymbol) BC048472 uc288yek.1 uc288yek.1 
ENSMUST00020183089.1 Gm56014 ENSMUST00020183089.1 Gm56014 (from geneSymbol) uc288yel.1 uc288yel.1 
ENSMUST00020183090.1 Gm54905 ENSMUST00020183090.1 Gm54905 (from geneSymbol) uc288yem.1 uc288yem.1 
ENSMUST00020183091.1 Gm55487 ENSMUST00020183091.1 Gm55487 (from geneSymbol) uc288yen.1 uc288yen.1 
ENSMUST00020183092.1 Gm55400 ENSMUST00020183092.1 Gm55400 (from geneSymbol) uc288yeo.1 uc288yeo.1 
ENSMUST00020183093.1 Gm55091 ENSMUST00020183093.1 Gm55091 (from geneSymbol) uc288yep.1 uc288yep.1 
ENSMUST00020183094.1 Gm54886 ENSMUST00020183094.1 Gm54886 (from geneSymbol) uc288yeq.1 uc288yeq.1 
ENSMUST00020183095.1 Gm54862 ENSMUST00020183095.1 Gm54862 (from geneSymbol) uc288yer.1 uc288yer.1 
ENSMUST00020183096.1 Gm55848 ENSMUST00020183096.1 Gm55848 (from geneSymbol) uc288yes.1 uc288yes.1 
ENSMUST00020183097.1 Gm55540 ENSMUST00020183097.1 Gm55540 (from geneSymbol) uc288yet.1 uc288yet.1 
ENSMUST00020183098.1 Gm55717 ENSMUST00020183098.1 Gm55717 (from geneSymbol) uc288yeu.1 uc288yeu.1 
ENSMUST00020183099.1 Gm56207 ENSMUST00020183099.1 Gm56207 (from geneSymbol) uc288yev.1 uc288yev.1 
ENSMUST00020183100.1 Gm55302 ENSMUST00020183100.1 Gm55302 (from geneSymbol) uc288yew.1 uc288yew.1 
ENSMUST00020183101.1 Gm54588 ENSMUST00020183101.1 Gm54588 (from geneSymbol) DQ540915 uc288yex.1 uc288yex.1 
ENSMUST00020183102.1 Gm54836 ENSMUST00020183102.1 Gm54836 (from geneSymbol) uc288yey.1 uc288yey.1 
ENSMUST00020183103.1 Gm55160 ENSMUST00020183103.1 Gm55160 (from geneSymbol) uc288yez.1 uc288yez.1 
ENSMUST00020183104.1 Gm56215 ENSMUST00020183104.1 Gm56215 (from geneSymbol) uc288yfa.1 uc288yfa.1 
ENSMUST00020183105.1 Gm54589 ENSMUST00020183105.1 Gm54589 (from geneSymbol) uc288yfb.1 uc288yfb.1 
ENSMUST00020183106.1 Gm54822 ENSMUST00020183106.1 Gm54822 (from geneSymbol) uc288yfc.1 uc288yfc.1 
ENSMUST00020183107.1 Gm55938 ENSMUST00020183107.1 Gm55938 (from geneSymbol) uc288yfd.1 uc288yfd.1 
ENSMUST00020183108.1 Gm56079 ENSMUST00020183108.1 Gm56079 (from geneSymbol) uc288yfe.1 uc288yfe.1 
ENSMUST00020183109.1 Gm55609 ENSMUST00020183109.1 Gm55609 (from geneSymbol) uc288yff.1 uc288yff.1 
ENSMUST00020183110.1 Gm54697 ENSMUST00020183110.1 Gm54697 (from geneSymbol) LF202308 uc288yfg.1 uc288yfg.1 
ENSMUST00020183111.1 Gm55574 ENSMUST00020183111.1 Gm55574 (from geneSymbol) uc288yfh.1 uc288yfh.1 
ENSMUST00020183112.1 Gm55024 ENSMUST00020183112.1 Gm55024 (from geneSymbol) uc288yfi.1 uc288yfi.1 
ENSMUST00020183113.1 Gm27572 ENSMUST00020183113.1 Gm27572 (from geneSymbol) uc288yfj.1 uc288yfj.1 
ENSMUST00020183114.1 Gm54555 ENSMUST00020183114.1 Gm54555 (from geneSymbol) DQ541194 uc288yfk.1 uc288yfk.1 
ENSMUST00020183115.1 Gm55979 ENSMUST00020183115.1 Gm55979 (from geneSymbol) uc288yfl.1 uc288yfl.1 
ENSMUST00020183116.1 Gm54486 ENSMUST00020183116.1 Gm54486 (from geneSymbol) DQ311494 uc288yfm.1 uc288yfm.1 
ENSMUST00020183117.1 Gm56063 ENSMUST00020183117.1 Gm56063 (from geneSymbol) uc288yfn.1 uc288yfn.1 
ENSMUST00020183118.1 Gm54609 ENSMUST00020183118.1 Gm54609 (from geneSymbol) uc288yfo.1 uc288yfo.1 
ENSMUST00020183119.1 Gm55677 ENSMUST00020183119.1 Gm55677 (from geneSymbol) uc288yfp.1 uc288yfp.1 
ENSMUST00020183120.1 Gm55973 ENSMUST00020183120.1 Gm55973 (from geneSymbol) DQ311494 uc288yfq.1 uc288yfq.1 
ENSMUST00020183121.1 Gm55774 ENSMUST00020183121.1 Gm55774 (from geneSymbol) AB352282 uc288yfr.1 uc288yfr.1 
ENSMUST00020183122.1 Gm55272 ENSMUST00020183122.1 Gm55272 (from geneSymbol) uc288yfs.1 uc288yfs.1 
ENSMUST00020183123.1 Gm55410 ENSMUST00020183123.1 Gm55410 (from geneSymbol) uc288yft.1 uc288yft.1 
ENSMUST00020183124.1 Gm56193 ENSMUST00020183124.1 Gm56193 (from geneSymbol) uc288yfu.1 uc288yfu.1 
ENSMUST00020183125.1 Gm54978 ENSMUST00020183125.1 Gm54978 (from geneSymbol) uc288yfv.1 uc288yfv.1 
ENSMUST00020183126.1 Gm55220 ENSMUST00020183126.1 Gm55220 (from geneSymbol) DQ311494 uc288yfw.1 uc288yfw.1 
ENSMUST00020183127.1 Gm54865 ENSMUST00020183127.1 Gm54865 (from geneSymbol) uc288yfx.1 uc288yfx.1 
ENSMUST00020183128.1 Gm54385 ENSMUST00020183128.1 Gm54385 (from geneSymbol) uc288yfy.1 uc288yfy.1 
ENSMUST00020183130.1 Gm54461 ENSMUST00020183130.1 Gm54461 (from geneSymbol) uc288yga.1 uc288yga.1 
ENSMUST00020183131.1 Gm55698 ENSMUST00020183131.1 Gm55698 (from geneSymbol) uc288ygb.1 uc288ygb.1 
ENSMUST00020183132.1 Gm55534 ENSMUST00020183132.1 Gm55534 (from geneSymbol) uc288ygc.1 uc288ygc.1 
ENSMUST00020183133.1 Gm56245 ENSMUST00020183133.1 Gm56245 (from geneSymbol) AB352500 uc288ygd.1 uc288ygd.1 
ENSMUST00020183134.1 Gm56189 ENSMUST00020183134.1 Gm56189 (from geneSymbol) uc288yge.1 uc288yge.1 
ENSMUST00020183135.1 Gm56191 ENSMUST00020183135.1 Gm56191 (from geneSymbol) uc288ygf.1 uc288ygf.1 
ENSMUST00020183136.1 Gm56077 ENSMUST00020183136.1 Gm56077 (from geneSymbol) DQ541194 uc288ygg.1 uc288ygg.1 
ENSMUST00020183137.1 Gm55055 ENSMUST00020183137.1 Gm55055 (from geneSymbol) uc288ygh.1 uc288ygh.1 
ENSMUST00020183138.1 Gm55333 ENSMUST00020183138.1 Gm55333 (from geneSymbol) uc288ygi.1 uc288ygi.1 
ENSMUST00020183139.1 Gm55437 ENSMUST00020183139.1 Gm55437 (from geneSymbol) uc288ygj.1 uc288ygj.1 
ENSMUST00020183140.1 Gm56255 ENSMUST00020183140.1 Gm56255 (from geneSymbol) uc288ygk.1 uc288ygk.1 
ENSMUST00020183141.1 Gm54929 ENSMUST00020183141.1 Gm54929 (from geneSymbol) uc288ygl.1 uc288ygl.1 
ENSMUST00020183142.1 Gm55133 ENSMUST00020183142.1 Gm55133 (from geneSymbol) uc288ygm.1 uc288ygm.1 
ENSMUST00020183143.1 Gm55068 ENSMUST00020183143.1 Gm55068 (from geneSymbol) LF202020 uc288ygn.1 uc288ygn.1 
ENSMUST00020183144.1 Gm55767 ENSMUST00020183144.1 Gm55767 (from geneSymbol) uc288ygo.1 uc288ygo.1 
ENSMUST00020183145.1 Gm55375 ENSMUST00020183145.1 Gm55375 (from geneSymbol) uc288ygp.1 uc288ygp.1 
ENSMUST00020183146.1 Gm55344 ENSMUST00020183146.1 Gm55344 (from geneSymbol) uc288ygq.1 uc288ygq.1 
ENSMUST00020183147.1 Gm55751 ENSMUST00020183147.1 Gm55751 (from geneSymbol) uc288ygr.1 uc288ygr.1 
ENSMUST00020183148.1 Gm56012 ENSMUST00020183148.1 Gm56012 (from geneSymbol) uc288ygs.1 uc288ygs.1 
ENSMUST00020183149.1 Gm56343 ENSMUST00020183149.1 Gm56343 (from geneSymbol) uc288ygt.1 uc288ygt.1 
ENSMUST00020183150.1 Gm55632 ENSMUST00020183150.1 Gm55632 (from geneSymbol) DQ311577 uc288ygu.1 uc288ygu.1 
ENSMUST00020183151.1 Gm54601 ENSMUST00020183151.1 Gm54601 (from geneSymbol) uc288ygv.1 uc288ygv.1 
ENSMUST00020183152.1 Gm55824 ENSMUST00020183152.1 Gm55824 (from geneSymbol) uc288ygw.1 uc288ygw.1 
ENSMUST00020183153.1 Gm54684 ENSMUST00020183153.1 Gm54684 (from geneSymbol) uc288ygx.1 uc288ygx.1 
ENSMUST00020183154.1 Gm55479 ENSMUST00020183154.1 Gm55479 (from geneSymbol) AB352500 uc288ygy.1 uc288ygy.1 
ENSMUST00020183155.1 Gm55890 ENSMUST00020183155.1 Gm55890 (from geneSymbol) uc288ygz.1 uc288ygz.1 
ENSMUST00020183156.1 Gm55357 ENSMUST00020183156.1 Gm55357 (from geneSymbol) uc288yha.1 uc288yha.1 
ENSMUST00020183157.1 Gm56180 ENSMUST00020183157.1 Gm56180 (from geneSymbol) LF193159 uc288yhb.1 uc288yhb.1 
ENSMUST00020183158.1 Gm55958 ENSMUST00020183158.1 Gm55958 (from geneSymbol) uc288yhc.1 uc288yhc.1 
ENSMUST00020183159.1 Gm54759 ENSMUST00020183159.1 Gm54759 (from geneSymbol) uc288yhd.1 uc288yhd.1 
ENSMUST00020183160.1 Gm55806 ENSMUST00020183160.1 Gm55806 (from geneSymbol) uc288yhe.1 uc288yhe.1 
ENSMUST00020183161.1 Gm56069 ENSMUST00020183161.1 Gm56069 (from geneSymbol) uc288yhf.1 uc288yhf.1 
ENSMUST00020183162.1 Gm55472 ENSMUST00020183162.1 Gm55472 (from geneSymbol) uc288yhg.1 uc288yhg.1 
ENSMUST00020183163.1 Gm55083 ENSMUST00020183163.1 Gm55083 (from geneSymbol) EF648170 uc288yhh.1 uc288yhh.1 
ENSMUST00020183164.1 Gm55411 ENSMUST00020183164.1 Gm55411 (from geneSymbol) uc288yhi.1 uc288yhi.1 
ENSMUST00020183165.1 Gm55070 ENSMUST00020183165.1 Gm55070 (from geneSymbol) LF202093 uc288yhj.1 uc288yhj.1 
ENSMUST00020183166.1 Gm55668 ENSMUST00020183166.1 Gm55668 (from geneSymbol) uc288yhk.1 uc288yhk.1 
ENSMUST00020183167.1 Gm54680 ENSMUST00020183167.1 Gm54680 (from geneSymbol) uc288yhl.1 uc288yhl.1 
ENSMUST00020183168.1 Gm56335 ENSMUST00020183168.1 Gm56335 (from geneSymbol) uc288yhm.1 uc288yhm.1 
ENSMUST00020183169.1 Gm56427 ENSMUST00020183169.1 Gm56427 (from geneSymbol) LF198342 uc288yhn.1 uc288yhn.1 
ENSMUST00020183170.1 Gm55786 ENSMUST00020183170.1 Gm55786 (from geneSymbol) uc288yho.1 uc288yho.1 
ENSMUST00020183171.1 Gm56463 ENSMUST00020183171.1 Gm56463 (from geneSymbol) uc288yhp.1 uc288yhp.1 
ENSMUST00020183172.1 Gm54846 ENSMUST00020183172.1 Gm54846 (from geneSymbol) uc288yhq.1 uc288yhq.1 
ENSMUST00020183173.1 Gm54615 ENSMUST00020183173.1 Gm54615 (from geneSymbol) uc288yhr.1 uc288yhr.1 
ENSMUST00020183174.1 Gm54823 ENSMUST00020183174.1 Gm54823 (from geneSymbol) uc288yhs.1 uc288yhs.1 
ENSMUST00020183175.1 Gm56381 ENSMUST00020183175.1 Gm56381 (from geneSymbol) DQ541194 uc288yht.1 uc288yht.1 
ENSMUST00020183176.1 Gm55865 ENSMUST00020183176.1 Gm55865 (from geneSymbol) AB352282 uc288yhu.1 uc288yhu.1 
ENSMUST00020183177.1 Gm55526 ENSMUST00020183177.1 Gm55526 (from geneSymbol) uc288yhv.1 uc288yhv.1 
ENSMUST00020183178.1 Gm55273 ENSMUST00020183178.1 Gm55273 (from geneSymbol) DQ311494 uc288yhw.1 uc288yhw.1 
ENSMUST00020183179.1 Gm54395 ENSMUST00020183179.1 Gm54395 (from geneSymbol) uc288yhx.1 uc288yhx.1 
ENSMUST00020183180.1 Gm55847 ENSMUST00020183180.1 Gm55847 (from geneSymbol) uc288yhy.1 uc288yhy.1 
ENSMUST00020183181.1 Gm55675 ENSMUST00020183181.1 Gm55675 (from geneSymbol) AB351420 uc288yhz.1 uc288yhz.1 
ENSMUST00020183182.1 Gm54467 ENSMUST00020183182.1 Gm54467 (from geneSymbol) uc288yia.1 uc288yia.1 
ENSMUST00020183183.1 Gm55420 ENSMUST00020183183.1 Gm55420 (from geneSymbol) uc288yib.1 uc288yib.1 
ENSMUST00020183184.1 Gm56108 ENSMUST00020183184.1 Gm56108 (from geneSymbol) uc288yic.1 uc288yic.1 
ENSMUST00020183185.1 Gm56140 ENSMUST00020183185.1 Gm56140 (from geneSymbol) uc288yid.1 uc288yid.1 
ENSMUST00020183186.1 Gm54635 ENSMUST00020183186.1 Gm54635 (from geneSymbol) uc288yie.1 uc288yie.1 
ENSMUST00020183187.1 Gm56277 ENSMUST00020183187.1 Gm56277 (from geneSymbol) uc288yif.1 uc288yif.1 
ENSMUST00020183188.1 Gm55040 ENSMUST00020183188.1 Gm55040 (from geneSymbol) uc288yig.1 uc288yig.1 
ENSMUST00020183189.1 Gm54883 ENSMUST00020183189.1 Gm54883 (from geneSymbol) uc288yih.1 uc288yih.1 
ENSMUST00020183190.1 Gm54931 ENSMUST00020183190.1 Gm54931 (from geneSymbol) uc288yii.1 uc288yii.1 
ENSMUST00020183191.1 Gm54679 ENSMUST00020183191.1 Gm54679 (from geneSymbol) uc288yij.1 uc288yij.1 
ENSMUST00020183192.1 Gm55773 ENSMUST00020183192.1 Gm55773 (from geneSymbol) uc288yik.1 uc288yik.1 
ENSMUST00020183193.1 Gm56037 ENSMUST00020183193.1 Gm56037 (from geneSymbol) uc288yil.1 uc288yil.1 
ENSMUST00020183194.1 Gm55350 ENSMUST00020183194.1 Gm55350 (from geneSymbol) uc288yim.1 uc288yim.1 
ENSMUST00020183195.1 Gm55312 ENSMUST00020183195.1 Gm55312 (from geneSymbol) uc288yin.1 uc288yin.1 
ENSMUST00020183196.1 Gm54973 ENSMUST00020183196.1 Gm54973 (from geneSymbol) uc288yio.1 uc288yio.1 
ENSMUST00020183197.1 Gm55230 ENSMUST00020183197.1 Gm55230 (from geneSymbol) uc288yip.1 uc288yip.1 
ENSMUST00020183198.1 Gm55809 ENSMUST00020183198.1 Gm55809 (from geneSymbol) uc288yiq.1 uc288yiq.1 
ENSMUST00020183199.1 Gm54525 ENSMUST00020183199.1 Gm54525 (from geneSymbol) uc288yir.1 uc288yir.1 
ENSMUST00020183201.1 Gm56376 ENSMUST00020183201.1 Gm56376 (from geneSymbol) uc288yit.1 uc288yit.1 
ENSMUST00020183202.1 Gm54414 ENSMUST00020183202.1 Gm54414 (from geneSymbol) uc288yiu.1 uc288yiu.1 
ENSMUST00020183203.1 Gm55282 ENSMUST00020183203.1 Gm55282 (from geneSymbol) DQ311494 uc288yiv.1 uc288yiv.1 
ENSMUST00020183204.1 Gm54887 ENSMUST00020183204.1 Gm54887 (from geneSymbol) DQ311494 uc288yiw.1 uc288yiw.1 
ENSMUST00020183205.1 Gm54788 ENSMUST00020183205.1 Gm54788 (from geneSymbol) uc288yix.1 uc288yix.1 
ENSMUST00020183206.1 Gm54387 ENSMUST00020183206.1 Gm54387 (from geneSymbol) uc288yiy.1 uc288yiy.1 
ENSMUST00020183207.1 Gm55095 ENSMUST00020183207.1 Gm55095 (from geneSymbol) LF234681 uc288yiz.1 uc288yiz.1 
ENSMUST00020183208.1 Gm55477 ENSMUST00020183208.1 Gm55477 (from geneSymbol) DQ860413 uc288yja.1 uc288yja.1 
ENSMUST00020183209.1 Gm55703 ENSMUST00020183209.1 Gm55703 (from geneSymbol) uc288yjb.1 uc288yjb.1 
ENSMUST00020183210.1 Gm56274 ENSMUST00020183210.1 Gm56274 (from geneSymbol) uc288yjc.1 uc288yjc.1 
ENSMUST00020183211.1 Gm54860 ENSMUST00020183211.1 Gm54860 (from geneSymbol) uc288yjd.1 uc288yjd.1 
ENSMUST00020183212.1 Gm55217 ENSMUST00020183212.1 Gm55217 (from geneSymbol) uc288yje.1 uc288yje.1 
ENSMUST00020183213.1 Gm56458 ENSMUST00020183213.1 Gm56458 (from geneSymbol) LF193813 uc288yjf.1 uc288yjf.1 
ENSMUST00020183214.1 Gm54915 ENSMUST00020183214.1 Gm54915 (from geneSymbol) uc288yjg.1 uc288yjg.1 
ENSMUST00020183215.1 Gm56169 ENSMUST00020183215.1 Gm56169 (from geneSymbol) uc288yjh.1 uc288yjh.1 
ENSMUST00020183216.1 Gm55185 ENSMUST00020183216.1 Gm55185 (from geneSymbol) uc288yji.1 uc288yji.1 
ENSMUST00020183217.1 Gm56158 ENSMUST00020183217.1 Gm56158 (from geneSymbol) uc288yjj.1 uc288yjj.1 
ENSMUST00020183218.1 Gm54876 ENSMUST00020183218.1 Gm54876 (from geneSymbol) LF200555 uc288yjk.1 uc288yjk.1 
ENSMUST00020183219.1 Gm55857 ENSMUST00020183219.1 Gm55857 (from geneSymbol) uc288yjl.1 uc288yjl.1 
ENSMUST00020183220.1 Gm55146 ENSMUST00020183220.1 Gm55146 (from geneSymbol) uc288yjm.1 uc288yjm.1 
ENSMUST00020183221.1 Gm54654 ENSMUST00020183221.1 Gm54654 (from geneSymbol) uc288yjn.1 uc288yjn.1 
ENSMUST00020183222.1 Gm56040 ENSMUST00020183222.1 Gm56040 (from geneSymbol) uc288yjo.1 uc288yjo.1 
ENSMUST00020183223.1 Gm54362 ENSMUST00020183223.1 Gm54362 (from geneSymbol) uc288yjp.1 uc288yjp.1 
ENSMUST00020183224.1 Gm56234 ENSMUST00020183224.1 Gm56234 (from geneSymbol) uc288yjq.1 uc288yjq.1 
ENSMUST00020183225.1 Gm56064 ENSMUST00020183225.1 Gm56064 (from geneSymbol) uc288yjr.1 uc288yjr.1 
ENSMUST00020183226.1 Gm55154 ENSMUST00020183226.1 Gm55154 (from geneSymbol) uc288yjs.1 uc288yjs.1 
ENSMUST00020183227.1 Snord3b4 ENSMUST00020183227.1 small nucleolar RNA, C/D box 3B4 (from RefSeq NR_002843.2) NR_002843 uc288yjt.1 uc288yjt.1 
ENSMUST00020183228.1 Gm55518 ENSMUST00020183228.1 Gm55518 (from geneSymbol) uc288yju.1 uc288yju.1 
ENSMUST00020183229.1 Gm56114 ENSMUST00020183229.1 Gm56114 (from geneSymbol) LF193539 uc288yjv.1 uc288yjv.1 
ENSMUST00020183230.1 Gm55082 ENSMUST00020183230.1 Gm55082 (from geneSymbol) AF357409 uc288yjw.1 uc288yjw.1 
ENSMUST00020183231.1 Gm54812 ENSMUST00020183231.1 Gm54812 (from geneSymbol) uc288yjx.1 uc288yjx.1 
ENSMUST00020183232.1 Gm55036 ENSMUST00020183232.1 Gm55036 (from geneSymbol) uc288yjy.1 uc288yjy.1 
ENSMUST00020183233.1 Gm55625 ENSMUST00020183233.1 Gm55625 (from geneSymbol) AY572459 uc288yjz.1 uc288yjz.1 
ENSMUST00020183234.1 Gm55289 ENSMUST00020183234.1 Gm55289 (from geneSymbol) uc288yka.1 uc288yka.1 
ENSMUST00020183235.1 Gm54980 ENSMUST00020183235.1 Gm54980 (from geneSymbol) uc288ykb.1 uc288ykb.1 
ENSMUST00020183236.1 Gm55827 ENSMUST00020183236.1 Gm55827 (from geneSymbol) uc288ykc.1 uc288ykc.1 
ENSMUST00020183237.1 Gm56466 ENSMUST00020183237.1 Gm56466 (from geneSymbol) uc288ykd.1 uc288ykd.1 
ENSMUST00020183238.1 Gm56411 ENSMUST00020183238.1 Gm56411 (from geneSymbol) uc288yke.1 uc288yke.1 
ENSMUST00020183239.1 Gm56104 ENSMUST00020183239.1 Gm56104 (from geneSymbol) uc288ykf.1 uc288ykf.1 
ENSMUST00020183240.1 Gm55138 ENSMUST00020183240.1 Gm55138 (from geneSymbol) uc288ykg.1 uc288ykg.1 
ENSMUST00020183241.1 Gm55656 ENSMUST00020183241.1 Gm55656 (from geneSymbol) uc288ykh.1 uc288ykh.1 
ENSMUST00020183242.1 Gm55997 ENSMUST00020183242.1 Gm55997 (from geneSymbol) uc288yki.1 uc288yki.1 
ENSMUST00020183243.1 Gm55235 ENSMUST00020183243.1 Gm55235 (from geneSymbol) uc288ykj.1 uc288ykj.1 
ENSMUST00020183244.1 Gm54753 ENSMUST00020183244.1 Gm54753 (from geneSymbol) uc288ykk.1 uc288ykk.1 
ENSMUST00020183245.1 Gm54833 ENSMUST00020183245.1 Gm54833 (from geneSymbol) uc288ykl.1 uc288ykl.1 
ENSMUST00020183246.1 Gm55558 ENSMUST00020183246.1 Gm55558 (from geneSymbol) uc288ykm.1 uc288ykm.1 
ENSMUST00020183247.1 Gm56272 ENSMUST00020183247.1 Gm56272 (from geneSymbol) uc288ykn.1 uc288ykn.1 
ENSMUST00020183248.1 Gm55261 ENSMUST00020183248.1 Gm55261 (from geneSymbol) uc288yko.1 uc288yko.1 
ENSMUST00020183249.1 Gm55469 ENSMUST00020183249.1 Gm55469 (from geneSymbol) uc288ykp.1 uc288ykp.1 
ENSMUST00020183250.1 Gm55872 ENSMUST00020183250.1 Gm55872 (from geneSymbol) uc288ykq.1 uc288ykq.1 
ENSMUST00020183251.1 Gm54732 ENSMUST00020183251.1 Gm54732 (from geneSymbol) uc288ykr.1 uc288ykr.1 
ENSMUST00020183252.1 Gm54953 ENSMUST00020183252.1 Gm54953 (from geneSymbol) uc288yks.1 uc288yks.1 
ENSMUST00020183253.1 Rn7sk ENSMUST00020183253.1 RNA, 7SK, nuclear (from RefSeq NR_030687.1) NR_030687 uc288ykt.1 uc288ykt.1 
ENSMUST00020183254.1 Gm54455 ENSMUST00020183254.1 Gm54455 (from geneSymbol) uc288yku.1 uc288yku.1 
ENSMUST00020183255.1 Gm56409 ENSMUST00020183255.1 Gm56409 (from geneSymbol) uc288ykv.1 uc288ykv.1 
ENSMUST00020183256.1 Gm55446 ENSMUST00020183256.1 Gm55446 (from geneSymbol) DQ311494 uc288ykw.1 uc288ykw.1 
ENSMUST00020183257.1 Gm54976 ENSMUST00020183257.1 Gm54976 (from geneSymbol) uc288ykx.1 uc288ykx.1 
ENSMUST00020183258.1 Gm55436 ENSMUST00020183258.1 Gm55436 (from geneSymbol) uc288yky.1 uc288yky.1 
ENSMUST00020183259.1 Gm54854 ENSMUST00020183259.1 Gm54854 (from geneSymbol) uc288ykz.1 uc288ykz.1 
ENSMUST00020183260.1 Gm55442 ENSMUST00020183260.1 Gm55442 (from geneSymbol) uc288yla.1 uc288yla.1 
ENSMUST00020183261.1 Gm56426 ENSMUST00020183261.1 Gm56426 (from geneSymbol) AK049839 uc288ylb.1 uc288ylb.1 
ENSMUST00020183262.1 Gm54920 ENSMUST00020183262.1 Gm54920 (from geneSymbol) uc288ylc.1 uc288ylc.1 
ENSMUST00020183263.1 Gm55260 ENSMUST00020183263.1 Gm55260 (from geneSymbol) LF204678 uc288yld.1 uc288yld.1 
ENSMUST00020183264.1 Gm54480 ENSMUST00020183264.1 Gm54480 (from geneSymbol) uc288yle.1 uc288yle.1 
ENSMUST00020183265.1 Gm55080 ENSMUST00020183265.1 Gm55080 (from geneSymbol) AB352278 uc288ylf.1 uc288ylf.1 
ENSMUST00020183266.1 Gm55765 ENSMUST00020183266.1 Gm55765 (from geneSymbol) uc288ylg.1 uc288ylg.1 
ENSMUST00020183267.1 Gm56144 ENSMUST00020183267.1 Gm56144 (from geneSymbol) uc288ylh.1 uc288ylh.1 
ENSMUST00020183268.1 Gm54596 ENSMUST00020183268.1 Gm54596 (from geneSymbol) uc288yli.1 uc288yli.1 
ENSMUST00020183269.1 Gm54968 ENSMUST00020183269.1 Gm54968 (from geneSymbol) uc288ylj.1 uc288ylj.1 
ENSMUST00020183270.1 Gm56417 ENSMUST00020183270.1 Gm56417 (from geneSymbol) DQ311494 uc288ylk.1 uc288ylk.1 
ENSMUST00020183271.1 Gm54754 ENSMUST00020183271.1 Gm54754 (from geneSymbol) DQ541194 uc288yll.1 uc288yll.1 
ENSMUST00020183272.1 Gm54667 ENSMUST00020183272.1 Gm54667 (from geneSymbol) AB352500 uc288ylm.1 uc288ylm.1 
ENSMUST00020183273.1 Gm55850 ENSMUST00020183273.1 Gm55850 (from geneSymbol) uc288yln.1 uc288yln.1 
ENSMUST00020183274.1 Gm56337 ENSMUST00020183274.1 Gm56337 (from geneSymbol) uc288ylo.1 uc288ylo.1 
ENSMUST00020183275.1 Gm55903 ENSMUST00020183275.1 Gm55903 (from geneSymbol) uc288ylp.1 uc288ylp.1 
ENSMUST00020183276.1 Gm55770 ENSMUST00020183276.1 Gm55770 (from geneSymbol) uc288ylq.1 uc288ylq.1 
ENSMUST00020183277.1 Gm54795 ENSMUST00020183277.1 Gm54795 (from geneSymbol) uc288ylr.1 uc288ylr.1 
ENSMUST00020183278.1 Gm56035 ENSMUST00020183278.1 Gm56035 (from geneSymbol) AB352978 uc288yls.1 uc288yls.1 
ENSMUST00020183279.1 Gm56182 ENSMUST00020183279.1 Gm56182 (from geneSymbol) uc288ylt.1 uc288ylt.1 
ENSMUST00020183280.1 Gm54840 ENSMUST00020183280.1 Gm54840 (from geneSymbol) uc288ylu.1 uc288ylu.1 
ENSMUST00020183281.1 Gm54720 ENSMUST00020183281.1 Gm54720 (from geneSymbol) uc288ylv.1 uc288ylv.1 
ENSMUST00020183282.1 Gm56166 ENSMUST00020183282.1 Gm56166 (from geneSymbol) uc288ylw.1 uc288ylw.1 
ENSMUST00020183283.1 Gm56136 ENSMUST00020183283.1 Gm56136 (from geneSymbol) uc288ylx.1 uc288ylx.1 
ENSMUST00020183284.1 Gm54677 ENSMUST00020183284.1 Gm54677 (from geneSymbol) uc288yly.1 uc288yly.1 
ENSMUST00020183285.1 Gm54790 ENSMUST00020183285.1 Gm54790 (from geneSymbol) AK043864 uc288ylz.1 uc288ylz.1 
ENSMUST00020183286.1 Gm54396 ENSMUST00020183286.1 Gm54396 (from geneSymbol) uc288yma.1 uc288yma.1 
ENSMUST00020183287.1 Gm55567 ENSMUST00020183287.1 Gm55567 (from geneSymbol) uc288ymb.1 uc288ymb.1 
ENSMUST00020183288.1 Gm56177 ENSMUST00020183288.1 Gm56177 (from geneSymbol) AB352500 uc288ymc.1 uc288ymc.1 
ENSMUST00020183289.1 Gm56420 ENSMUST00020183289.1 Gm56420 (from geneSymbol) LF196711 uc288ymd.1 uc288ymd.1 
ENSMUST00020183290.1 Gm55281 ENSMUST00020183290.1 Gm55281 (from geneSymbol) uc288yme.1 uc288yme.1 
ENSMUST00020183291.1 Gm55484 ENSMUST00020183291.1 Gm55484 (from geneSymbol) uc288ymf.1 uc288ymf.1 
ENSMUST00020183292.1 Gm54561 ENSMUST00020183292.1 Gm54561 (from geneSymbol) uc288ymg.1 uc288ymg.1 
ENSMUST00020183293.1 Gm55885 ENSMUST00020183293.1 Gm55885 (from geneSymbol) uc288ymh.1 uc288ymh.1 
ENSMUST00020183294.1 Gm55692 ENSMUST00020183294.1 Gm55692 (from geneSymbol) uc288ymi.1 uc288ymi.1 
ENSMUST00020183295.1 Gm54507 ENSMUST00020183295.1 Gm54507 (from geneSymbol) MS816678 uc288ymj.1 uc288ymj.1 
ENSMUST00020183296.1 Gm54536 ENSMUST00020183296.1 Gm54536 (from geneSymbol) DQ311494 uc288ymk.1 uc288ymk.1 
ENSMUST00020183297.1 Gm56013 ENSMUST00020183297.1 Gm56013 (from geneSymbol) uc288yml.1 uc288yml.1 
ENSMUST00020183298.1 Gm55689 ENSMUST00020183298.1 Gm55689 (from geneSymbol) uc288ymm.1 uc288ymm.1 
ENSMUST00020183299.1 Gm56364 ENSMUST00020183299.1 Gm56364 (from geneSymbol) uc288ymn.1 uc288ymn.1 
ENSMUST00020183300.1 Gm54955 ENSMUST00020183300.1 Gm54955 (from geneSymbol) uc288ymo.1 uc288ymo.1 
ENSMUST00020183301.1 Gm54724 ENSMUST00020183301.1 Gm54724 (from geneSymbol) DQ311494 uc288ymp.1 uc288ymp.1 
ENSMUST00020183302.1 Gm55728 ENSMUST00020183302.1 Gm55728 (from geneSymbol) uc288ymq.1 uc288ymq.1 
ENSMUST00020183303.1 Gm55067 ENSMUST00020183303.1 Gm55067 (from geneSymbol) uc288ymr.1 uc288ymr.1 
ENSMUST00020183304.1 Gm55781 ENSMUST00020183304.1 Gm55781 (from geneSymbol) uc288yms.1 uc288yms.1 
ENSMUST00020183305.1 Gm56153 ENSMUST00020183305.1 Gm56153 (from geneSymbol) uc288ymt.1 uc288ymt.1 
ENSMUST00020183306.1 Gm54670 ENSMUST00020183306.1 Gm54670 (from geneSymbol) uc288ymu.1 uc288ymu.1 
ENSMUST00020183307.1 Gm54852 ENSMUST00020183307.1 Gm54852 (from geneSymbol) uc288ymv.1 uc288ymv.1 
ENSMUST00020183308.1 Gm55283 ENSMUST00020183308.1 Gm55283 (from geneSymbol) uc288ymw.1 uc288ymw.1 
ENSMUST00020183309.1 Gm54944 ENSMUST00020183309.1 Gm54944 (from geneSymbol) uc288ymx.1 uc288ymx.1 
ENSMUST00020183310.1 Gm56031 ENSMUST00020183310.1 Gm56031 (from geneSymbol) uc288ymy.1 uc288ymy.1 
ENSMUST00020183311.1 Gm54673 ENSMUST00020183311.1 Gm54673 (from geneSymbol) uc288ymz.1 uc288ymz.1 
ENSMUST00020183312.1 Gm56001 ENSMUST00020183312.1 Gm56001 (from geneSymbol) uc288yna.1 uc288yna.1 
ENSMUST00020183313.1 Gm55779 ENSMUST00020183313.1 Gm55779 (from geneSymbol) uc288ynb.1 uc288ynb.1 
ENSMUST00020183314.1 Gm54736 ENSMUST00020183314.1 Gm54736 (from geneSymbol) DQ311494 uc288ync.1 uc288ync.1 
ENSMUST00020183315.1 Gm54709 ENSMUST00020183315.1 Gm54709 (from geneSymbol) uc288ynd.1 uc288ynd.1 
ENSMUST00020183316.1 Gm54575 ENSMUST00020183316.1 Gm54575 (from geneSymbol) uc288yne.1 uc288yne.1 
ENSMUST00020183317.1 Gm54565 ENSMUST00020183317.1 Gm54565 (from geneSymbol) uc288ynf.1 uc288ynf.1 
ENSMUST00020183318.1 Gm55085 ENSMUST00020183318.1 Gm55085 (from geneSymbol) uc288yng.1 uc288yng.1 
ENSMUST00020183319.1 Gm54661 ENSMUST00020183319.1 Gm54661 (from geneSymbol) uc288ynh.1 uc288ynh.1 
ENSMUST00020183320.1 Gm55089 ENSMUST00020183320.1 Gm55089 (from geneSymbol) DQ311519 uc288yni.1 uc288yni.1 
ENSMUST00020183321.1 Gm56042 ENSMUST00020183321.1 Gm56042 (from geneSymbol) uc288ynj.1 uc288ynj.1 
ENSMUST00020183322.1 Gm55118 ENSMUST00020183322.1 Gm55118 (from geneSymbol) uc288ynk.1 uc288ynk.1 
ENSMUST00020183323.1 Gm55338 ENSMUST00020183323.1 Gm55338 (from geneSymbol) AB352621 uc288ynl.1 uc288ynl.1 
ENSMUST00020183324.1 Gm56328 ENSMUST00020183324.1 Gm56328 (from geneSymbol) uc288ynm.1 uc288ynm.1 
ENSMUST00020183326.1 Gm22711 ENSMUST00020183326.1 Gm22711 (from geneSymbol) uc288yno.1 uc288yno.1 
ENSMUST00020183327.1 Gm55511 ENSMUST00020183327.1 Gm55511 (from geneSymbol) uc288ynp.1 uc288ynp.1 
ENSMUST00020183328.1 Gm55449 ENSMUST00020183328.1 Gm55449 (from geneSymbol) uc288ynq.1 uc288ynq.1 
ENSMUST00020183329.1 Gm55228 ENSMUST00020183329.1 Gm55228 (from geneSymbol) uc288ynr.1 uc288ynr.1 
ENSMUST00020183330.1 Gm54917 ENSMUST00020183330.1 Gm54917 (from geneSymbol) uc288yns.1 uc288yns.1 
ENSMUST00020183331.1 Gm55378 ENSMUST00020183331.1 Gm55378 (from geneSymbol) uc288ynt.1 uc288ynt.1 
ENSMUST00020183332.1 Gm55940 ENSMUST00020183332.1 Gm55940 (from geneSymbol) DQ311523 uc288ynu.1 uc288ynu.1 
ENSMUST00020183333.1 Gm55543 ENSMUST00020183333.1 Gm55543 (from geneSymbol) uc288ynv.1 uc288ynv.1 
ENSMUST00020183334.1 Gm55175 ENSMUST00020183334.1 Gm55175 (from geneSymbol) DQ311523 uc288ynw.1 uc288ynw.1 
ENSMUST00020183335.1 Gm55721 ENSMUST00020183335.1 Gm55721 (from geneSymbol) uc288ynx.1 uc288ynx.1 
ENSMUST00020183336.1 Gm55630 ENSMUST00020183336.1 Gm55630 (from geneSymbol) DQ543817 uc288yny.1 uc288yny.1 
ENSMUST00020183337.1 Gm54674 ENSMUST00020183337.1 Gm54674 (from geneSymbol) AB351420 uc288ynz.1 uc288ynz.1 
ENSMUST00020183338.1 Gm55186 ENSMUST00020183338.1 Gm55186 (from geneSymbol) uc288yoa.1 uc288yoa.1 
ENSMUST00020183339.1 Gm54603 ENSMUST00020183339.1 Gm54603 (from geneSymbol) uc288yob.1 uc288yob.1 
ENSMUST00020183340.1 Gm56269 ENSMUST00020183340.1 Gm56269 (from geneSymbol) uc288yoc.1 uc288yoc.1 
ENSMUST00020183341.1 Gm54358 ENSMUST00020183341.1 Gm54358 (from geneSymbol) uc288yod.1 uc288yod.1 
ENSMUST00020183342.1 Gm55845 ENSMUST00020183342.1 Gm55845 (from geneSymbol) uc288yoe.1 uc288yoe.1 
ENSMUST00020183343.1 Gm54620 ENSMUST00020183343.1 Gm54620 (from geneSymbol) uc288yof.1 uc288yof.1 
ENSMUST00020183344.1 Gm55522 ENSMUST00020183344.1 Gm55522 (from geneSymbol) JN695061 uc288yog.1 uc288yog.1 
ENSMUST00020183345.1 Gm55629 ENSMUST00020183345.1 Gm55629 (from geneSymbol) DQ543817 uc288yoh.1 uc288yoh.1 
ENSMUST00020183346.1 Gm54638 ENSMUST00020183346.1 Gm54638 (from geneSymbol) uc288yoi.1 uc288yoi.1 
ENSMUST00020183347.1 Gm56286 ENSMUST00020183347.1 Gm56286 (from geneSymbol) uc288yoj.1 uc288yoj.1 
ENSMUST00020183348.1 Gm56296 ENSMUST00020183348.1 Gm56296 (from geneSymbol) uc288yok.1 uc288yok.1 
ENSMUST00020183349.1 Gm55983 ENSMUST00020183349.1 Gm55983 (from geneSymbol) uc288yol.1 uc288yol.1 
ENSMUST00020183350.1 Gm56334 ENSMUST00020183350.1 Gm56334 (from geneSymbol) uc288yom.1 uc288yom.1 
ENSMUST00020183351.1 Gm54817 ENSMUST00020183351.1 Gm54817 (from geneSymbol) uc288yon.1 uc288yon.1 
ENSMUST00020183352.1 Gm55679 ENSMUST00020183352.1 Gm55679 (from geneSymbol) uc288yoo.1 uc288yoo.1 
ENSMUST00020183353.1 Gm55557 ENSMUST00020183353.1 Gm55557 (from geneSymbol) AB352621 uc288yop.1 uc288yop.1 
ENSMUST00020183354.1 Gm55013 ENSMUST00020183354.1 Gm55013 (from geneSymbol) uc288yoq.1 uc288yoq.1 
ENSMUST00020183355.1 Gm54758 ENSMUST00020183355.1 Gm54758 (from geneSymbol) uc288yor.1 uc288yor.1 
ENSMUST00020183356.1 Gm54913 ENSMUST00020183356.1 Gm54913 (from geneSymbol) AK217011 uc288yos.1 uc288yos.1 
ENSMUST00020183357.1 Gm55393 ENSMUST00020183357.1 Gm55393 (from geneSymbol) uc288yot.1 uc288yot.1 
ENSMUST00020183358.1 Gm54441 ENSMUST00020183358.1 Gm54441 (from geneSymbol) uc288you.1 uc288you.1 
ENSMUST00020183359.1 Gm55239 ENSMUST00020183359.1 Gm55239 (from geneSymbol) uc288yov.1 uc288yov.1 
ENSMUST00020183360.1 Gm56285 ENSMUST00020183360.1 Gm56285 (from geneSymbol) uc288yow.1 uc288yow.1 
ENSMUST00020183361.1 Gm55501 ENSMUST00020183361.1 Gm55501 (from geneSymbol) uc288yox.1 uc288yox.1 
ENSMUST00020183362.1 Gm56029 ENSMUST00020183362.1 Gm56029 (from geneSymbol) uc288yoy.1 uc288yoy.1 
ENSMUST00020183363.1 Gm54660 ENSMUST00020183363.1 Gm54660 (from geneSymbol) AB352621 uc288yoz.1 uc288yoz.1 
ENSMUST00020183364.1 Gm55691 ENSMUST00020183364.1 Gm55691 (from geneSymbol) uc288ypa.1 uc288ypa.1 
ENSMUST00020183365.1 Gm55398 ENSMUST00020183365.1 Gm55398 (from geneSymbol) uc288ypb.1 uc288ypb.1 
ENSMUST00020183366.1 Gm55925 ENSMUST00020183366.1 Gm55925 (from geneSymbol) uc288ypc.1 uc288ypc.1 
ENSMUST00020183367.1 Gm55819 ENSMUST00020183367.1 Gm55819 (from geneSymbol) uc288ypd.1 uc288ypd.1 
ENSMUST00020183368.1 Gm55459 ENSMUST00020183368.1 Gm55459 (from geneSymbol) uc288ype.1 uc288ype.1 
ENSMUST00020183369.1 Gm55554 ENSMUST00020183369.1 Gm55554 (from geneSymbol) uc288ypf.1 uc288ypf.1 
ENSMUST00020183370.1 Gm55039 ENSMUST00020183370.1 Gm55039 (from geneSymbol) uc288ypg.1 uc288ypg.1 
ENSMUST00020183371.1 Gm55022 ENSMUST00020183371.1 Gm55022 (from geneSymbol) uc288yph.1 uc288yph.1 
ENSMUST00020183372.1 Gm54847 ENSMUST00020183372.1 Gm54847 (from geneSymbol) uc288ypi.1 uc288ypi.1 
ENSMUST00020183373.1 Gm23370 ENSMUST00020183373.1 Gm23370 (from geneSymbol) uc288ypj.1 uc288ypj.1 
ENSMUST00020183374.1 Gm54409 ENSMUST00020183374.1 Gm54409 (from geneSymbol) AB352541 uc288ypk.1 uc288ypk.1 
ENSMUST00020183375.1 Gm56175 ENSMUST00020183375.1 Gm56175 (from geneSymbol) uc288ypl.1 uc288ypl.1 
ENSMUST00020183376.1 Gm55894 ENSMUST00020183376.1 Gm55894 (from geneSymbol) uc288ypm.1 uc288ypm.1 
ENSMUST00020183377.1 Gm56229 ENSMUST00020183377.1 Gm56229 (from geneSymbol) uc288ypn.1 uc288ypn.1 
ENSMUST00020183378.1 Gm54645 ENSMUST00020183378.1 Gm54645 (from geneSymbol) uc288ypo.1 uc288ypo.1 
ENSMUST00020183379.1 Gm55244 ENSMUST00020183379.1 Gm55244 (from geneSymbol) uc288ypp.1 uc288ypp.1 
ENSMUST00020183380.1 Gm55318 ENSMUST00020183380.1 Gm55318 (from geneSymbol) uc288ypq.1 uc288ypq.1 
ENSMUST00020183381.1 Gm56212 ENSMUST00020183381.1 Gm56212 (from geneSymbol) uc288ypr.1 uc288ypr.1 
ENSMUST00020183382.1 Gm55148 ENSMUST00020183382.1 Gm55148 (from geneSymbol) uc288yps.1 uc288yps.1 
ENSMUST00020183383.1 Gm55231 ENSMUST00020183383.1 Gm55231 (from geneSymbol) uc288ypt.1 uc288ypt.1 
ENSMUST00020183384.1 Gm55351 ENSMUST00020183384.1 Gm55351 (from geneSymbol) uc288ypu.1 uc288ypu.1 
ENSMUST00020183385.1 Gm55136 ENSMUST00020183385.1 Gm55136 (from geneSymbol) uc288ypv.1 uc288ypv.1 
ENSMUST00020183386.1 Gm56349 ENSMUST00020183386.1 Gm56349 (from geneSymbol) AB351420 uc288ypw.1 uc288ypw.1 
ENSMUST00020183387.1 Gm55795 ENSMUST00020183387.1 Gm55795 (from geneSymbol) uc288ypx.1 uc288ypx.1 
ENSMUST00020183388.1 Gm55980 ENSMUST00020183388.1 Gm55980 (from geneSymbol) uc288ypy.1 uc288ypy.1 
ENSMUST00020183389.1 Gm55515 ENSMUST00020183389.1 Gm55515 (from geneSymbol) uc288ypz.1 uc288ypz.1 
ENSMUST00020183390.1 Gm55792 ENSMUST00020183390.1 Gm55792 (from geneSymbol) uc288yqa.1 uc288yqa.1 
ENSMUST00020183391.1 Gm55701 ENSMUST00020183391.1 Gm55701 (from geneSymbol) uc288yqb.1 uc288yqb.1 
ENSMUST00020183392.1 Gm55945 ENSMUST00020183392.1 Gm55945 (from geneSymbol) uc288yqc.1 uc288yqc.1 
ENSMUST00020183393.1 Gm55910 ENSMUST00020183393.1 Gm55910 (from geneSymbol) uc288yqd.1 uc288yqd.1 
ENSMUST00020183394.1 Gm55382 ENSMUST00020183394.1 Gm55382 (from geneSymbol) DQ311494 uc288yqe.1 uc288yqe.1 
ENSMUST00020183395.1 Gm54989 ENSMUST00020183395.1 Gm54989 (from geneSymbol) DQ311494 uc288yqf.1 uc288yqf.1 
ENSMUST00020183396.1 Gm55880 ENSMUST00020183396.1 Gm55880 (from geneSymbol) LF204947 uc288yqg.1 uc288yqg.1 
ENSMUST00020183397.1 Gm54773 ENSMUST00020183397.1 Gm54773 (from geneSymbol) DQ311494 uc288yqh.1 uc288yqh.1 
ENSMUST00020183398.1 Gm54571 ENSMUST00020183398.1 Gm54571 (from geneSymbol) uc288yqi.1 uc288yqi.1 
ENSMUST00020183399.1 Gm55651 ENSMUST00020183399.1 Gm55651 (from geneSymbol) uc288yqj.1 uc288yqj.1 
ENSMUST00020183400.1 Gm55695 ENSMUST00020183400.1 Gm55695 (from geneSymbol) uc288yqk.1 uc288yqk.1 
ENSMUST00020183401.1 Gm56314 ENSMUST00020183401.1 Gm56314 (from geneSymbol) uc288yql.1 uc288yql.1 
ENSMUST00020183402.1 Gm56128 ENSMUST00020183402.1 Gm56128 (from geneSymbol) uc288yqm.1 uc288yqm.1 
ENSMUST00020183403.1 Gm54398 ENSMUST00020183403.1 Gm54398 (from geneSymbol) uc288yqn.1 uc288yqn.1 
ENSMUST00020183404.1 Gm55908 ENSMUST00020183404.1 Gm55908 (from geneSymbol) uc288yqo.1 uc288yqo.1 
ENSMUST00020183405.1 Gm55485 ENSMUST00020183405.1 Gm55485 (from geneSymbol) uc288yqp.1 uc288yqp.1 
ENSMUST00020183406.1 Gm54977 ENSMUST00020183406.1 Gm54977 (from geneSymbol) uc288yqq.1 uc288yqq.1 
ENSMUST00020183407.1 Gm26413 ENSMUST00020183407.1 Gm26413 (from geneSymbol) uc288yqr.1 uc288yqr.1 
ENSMUST00020183408.1 Gm55144 ENSMUST00020183408.1 Gm55144 (from geneSymbol) uc288yqs.1 uc288yqs.1 
ENSMUST00020183409.1 Gm56058 ENSMUST00020183409.1 Gm56058 (from geneSymbol) DQ311497 uc288yqt.1 uc288yqt.1 
ENSMUST00020183410.1 Gm55998 ENSMUST00020183410.1 Gm55998 (from geneSymbol) DQ311494 uc288yqu.1 uc288yqu.1 
ENSMUST00020183411.1 Gm56257 ENSMUST00020183411.1 Gm56257 (from geneSymbol) LF194360 uc288yqv.1 uc288yqv.1 
ENSMUST00020183412.1 Gm55608 ENSMUST00020183412.1 Gm55608 (from geneSymbol) uc288yqw.1 uc288yqw.1 
ENSMUST00020183413.1 Gm25179 ENSMUST00020183413.1 Gm25179 (from geneSymbol) uc288yqx.1 uc288yqx.1 
ENSMUST00020183414.1 Gm56476 ENSMUST00020183414.1 Gm56476 (from geneSymbol) LF193303 uc288yqy.1 uc288yqy.1 
ENSMUST00020183415.1 Gm54352 ENSMUST00020183415.1 Gm54352 (from geneSymbol) uc288yqz.1 uc288yqz.1 
ENSMUST00020183416.1 Gm55519 ENSMUST00020183416.1 Gm55519 (from geneSymbol) uc288yra.1 uc288yra.1 
ENSMUST00020183417.1 Snord3b3 ENSMUST00020183417.1 Snord3b3 (from geneSymbol) AK019039 uc288yrb.1 uc288yrb.1 
ENSMUST00020183418.1 Gm56431 ENSMUST00020183418.1 Gm56431 (from geneSymbol) LF196726 uc288yrc.1 uc288yrc.1 
ENSMUST00020183419.1 Gm56217 ENSMUST00020183419.1 Gm56217 (from geneSymbol) uc288yrd.1 uc288yrd.1 
ENSMUST00020183420.1 Gm54998 ENSMUST00020183420.1 Gm54998 (from geneSymbol) AB352500 uc288yre.1 uc288yre.1 
ENSMUST00020183421.1 Gm54416 ENSMUST00020183421.1 Gm54416 (from geneSymbol) AB351420 uc288yrf.1 uc288yrf.1 
ENSMUST00020183422.1 Gm56164 ENSMUST00020183422.1 Gm56164 (from geneSymbol) uc288yrg.1 uc288yrg.1 
ENSMUST00020183423.1 Gm56091 ENSMUST00020183423.1 Gm56091 (from geneSymbol) uc288yrh.1 uc288yrh.1 
ENSMUST00020183424.1 Gm55598 ENSMUST00020183424.1 Gm55598 (from geneSymbol) LF195769 uc288yri.1 uc288yri.1 
ENSMUST00020183425.1 Gm54530 ENSMUST00020183425.1 Gm54530 (from geneSymbol) uc288yrj.1 uc288yrj.1 
ENSMUST00020183426.1 Gm56050 ENSMUST00020183426.1 Gm56050 (from geneSymbol) uc288yrk.1 uc288yrk.1 
ENSMUST00020183427.1 Gm56103 ENSMUST00020183427.1 Gm56103 (from geneSymbol) uc288yrl.1 uc288yrl.1 
ENSMUST00020183428.1 Gm54692 ENSMUST00020183428.1 Gm54692 (from geneSymbol) uc288yrm.1 uc288yrm.1 
ENSMUST00020183429.1 Gm55043 ENSMUST00020183429.1 Gm55043 (from geneSymbol) uc288yrn.1 uc288yrn.1 
ENSMUST00020183431.1 Gm54503 ENSMUST00020183431.1 Gm54503 (from geneSymbol) uc288yrp.1 uc288yrp.1 
ENSMUST00020183432.1 Gm54861 ENSMUST00020183432.1 Gm54861 (from geneSymbol) LF205046 uc288yrq.1 uc288yrq.1 
ENSMUST00020183433.1 Gm56048 ENSMUST00020183433.1 Gm56048 (from geneSymbol) DQ311507 uc288yrr.1 uc288yrr.1 
ENSMUST00020183434.1 Gm54629 ENSMUST00020183434.1 Gm54629 (from geneSymbol) uc288yrs.1 uc288yrs.1 
ENSMUST00020183435.1 Scarna13 ENSMUST00020183435.1 small Cajal body-specific RNA 13 (from RefSeq NR_028576.1) NR_028576 uc288yrt.1 uc288yrt.1 
ENSMUST00020183436.1 Gm54701 ENSMUST00020183436.1 Gm54701 (from geneSymbol) uc288yru.1 uc288yru.1 
ENSMUST00020183437.1 Gm54838 ENSMUST00020183437.1 Gm54838 (from geneSymbol) DQ541194 uc288yrv.1 uc288yrv.1 
ENSMUST00020183438.1 Gm54481 ENSMUST00020183438.1 Gm54481 (from geneSymbol) uc288yrw.1 uc288yrw.1 
ENSMUST00020183439.1 Scarna3a ENSMUST00020183439.1 small Cajal body-specific RNA 3A (from RefSeq NR_028518.1) NR_028518 uc288yrx.1 uc288yrx.1 
ENSMUST00020183440.1 Gm55396 ENSMUST00020183440.1 Gm55396 (from geneSymbol) uc288yry.1 uc288yry.1 
ENSMUST00020183441.1 Gm56021 ENSMUST00020183441.1 Gm56021 (from geneSymbol) DQ311494 uc288yrz.1 uc288yrz.1 
ENSMUST00020183442.1 Gm54784 ENSMUST00020183442.1 Gm54784 (from geneSymbol) uc288ysa.1 uc288ysa.1 
ENSMUST00020183443.1 Gm54492 ENSMUST00020183443.1 Gm54492 (from geneSymbol) uc288ysb.1 uc288ysb.1 
ENSMUST00020183444.1 Gm55256 ENSMUST00020183444.1 Gm55256 (from geneSymbol) LF199647 uc288ysc.1 uc288ysc.1 
ENSMUST00020183445.1 Gm55718 ENSMUST00020183445.1 Gm55718 (from geneSymbol) uc288ysd.1 uc288ysd.1 
ENSMUST00020183446.1 Gm55685 ENSMUST00020183446.1 Gm55685 (from geneSymbol) uc288yse.1 uc288yse.1 
ENSMUST00020183447.1 Gm55610 ENSMUST00020183447.1 Gm55610 (from geneSymbol) uc288ysf.1 uc288ysf.1 
ENSMUST00020183448.1 Gm56462 ENSMUST00020183448.1 Gm56462 (from geneSymbol) uc288ysg.1 uc288ysg.1 
ENSMUST00020183449.1 Gm55206 ENSMUST00020183449.1 Gm55206 (from geneSymbol) uc288ysh.1 uc288ysh.1 
ENSMUST00020183450.1 Gm55063 ENSMUST00020183450.1 Gm55063 (from geneSymbol) uc288ysi.1 uc288ysi.1 
ENSMUST00020183451.1 Gm54569 ENSMUST00020183451.1 Gm54569 (from geneSymbol) uc288ysj.1 uc288ysj.1 
ENSMUST00020183452.1 Gm55323 ENSMUST00020183452.1 Gm55323 (from geneSymbol) uc288ysk.1 uc288ysk.1 
ENSMUST00020183453.1 Gm54429 ENSMUST00020183453.1 Gm54429 (from geneSymbol) LF200274 uc288ysl.1 uc288ysl.1 
ENSMUST00020183454.1 Gm54626 ENSMUST00020183454.1 Gm54626 (from geneSymbol) uc288ysm.1 uc288ysm.1 
ENSMUST00020183455.1 Gm56148 ENSMUST00020183455.1 Gm56148 (from geneSymbol) DQ311494 uc288ysn.1 uc288ysn.1 
ENSMUST00020183456.1 Gm56252 ENSMUST00020183456.1 Gm56252 (from geneSymbol) uc288yso.1 uc288yso.1 
ENSMUST00020183457.1 Gm56268 ENSMUST00020183457.1 Gm56268 (from geneSymbol) uc288ysp.1 uc288ysp.1 
ENSMUST00020183459.1 Gm54599 ENSMUST00020183459.1 Gm54599 (from geneSymbol) uc288ysr.1 uc288ysr.1 
ENSMUST00020183460.1 Gm55317 ENSMUST00020183460.1 Gm55317 (from geneSymbol) uc288yss.1 uc288yss.1 
ENSMUST00020183461.1 Gm55274 ENSMUST00020183461.1 Gm55274 (from geneSymbol) uc288yst.1 uc288yst.1 
ENSMUST00020183462.1 Gm54445 ENSMUST00020183462.1 Gm54445 (from geneSymbol) uc288ysu.1 uc288ysu.1 
ENSMUST00020183463.1 Gm55028 ENSMUST00020183463.1 Gm55028 (from geneSymbol) uc288ysv.1 uc288ysv.1 
ENSMUST00020183464.1 Gm55922 ENSMUST00020183464.1 Gm55922 (from geneSymbol) uc288ysw.1 uc288ysw.1 
ENSMUST00020183465.1 Gm54497 ENSMUST00020183465.1 Gm54497 (from geneSymbol) uc288ysx.1 uc288ysx.1 
ENSMUST00020183466.1 Gm56263 ENSMUST00020183466.1 Gm56263 (from geneSymbol) DQ311494 uc288ysy.1 uc288ysy.1 
ENSMUST00020183467.1 Gm55791 ENSMUST00020183467.1 Gm55791 (from geneSymbol) uc288ysz.1 uc288ysz.1 
ENSMUST00020183468.1 Gm56224 ENSMUST00020183468.1 Gm56224 (from geneSymbol) uc288yta.1 uc288yta.1 
ENSMUST00020183469.1 Gm56465 ENSMUST00020183469.1 Gm56465 (from geneSymbol) uc288ytb.1 uc288ytb.1 
ENSMUST00020183470.1 Gm55562 ENSMUST00020183470.1 Gm55562 (from geneSymbol) DQ311494 uc288ytc.1 uc288ytc.1 
ENSMUST00020183471.1 Gm55346 ENSMUST00020183471.1 Gm55346 (from geneSymbol) uc288ytd.1 uc288ytd.1 
ENSMUST00020183472.1 Gm55115 ENSMUST00020183472.1 Gm55115 (from geneSymbol) uc288yte.1 uc288yte.1 
ENSMUST00020183473.1 Gm54657 ENSMUST00020183473.1 Gm54657 (from geneSymbol) uc288ytf.1 uc288ytf.1 
ENSMUST00020183474.1 Gm56351 ENSMUST00020183474.1 Gm56351 (from geneSymbol) uc288ytg.1 uc288ytg.1 
ENSMUST00020183475.1 Gm56359 ENSMUST00020183475.1 Gm56359 (from geneSymbol) AB352951 uc288yth.1 uc288yth.1 
ENSMUST00020183476.1 Gm56295 ENSMUST00020183476.1 Gm56295 (from geneSymbol) uc288yti.1 uc288yti.1 
ENSMUST00020183477.1 Gm54774 ENSMUST00020183477.1 Gm54774 (from geneSymbol) uc288ytj.1 uc288ytj.1 
ENSMUST00020183478.1 Gm55727 ENSMUST00020183478.1 Gm55727 (from geneSymbol) uc288ytk.1 uc288ytk.1 
ENSMUST00020183479.1 Gm55967 ENSMUST00020183479.1 Gm55967 (from geneSymbol) uc288ytl.1 uc288ytl.1 
ENSMUST00020183480.1 Gm56401 ENSMUST00020183480.1 Gm56401 (from geneSymbol) uc288ytm.1 uc288ytm.1 
ENSMUST00020183481.1 Gm55605 ENSMUST00020183481.1 Gm55605 (from geneSymbol) uc288ytn.1 uc288ytn.1 
ENSMUST00020183482.1 Gm55358 ENSMUST00020183482.1 Gm55358 (from geneSymbol) uc288yto.1 uc288yto.1 
ENSMUST00020183483.1 Gm54785 ENSMUST00020183483.1 Gm54785 (from geneSymbol) AB351420 uc288ytp.1 uc288ytp.1 
ENSMUST00020183484.1 Gm55898 ENSMUST00020183484.1 Gm55898 (from geneSymbol) uc288ytq.1 uc288ytq.1 
ENSMUST00020183485.1 Gm55693 ENSMUST00020183485.1 Gm55693 (from geneSymbol) uc288ytr.1 uc288ytr.1 
ENSMUST00020183486.1 Gm54792 ENSMUST00020183486.1 Gm54792 (from geneSymbol) uc288yts.1 uc288yts.1 
ENSMUST00020183487.1 Gm55815 ENSMUST00020183487.1 Gm55815 (from geneSymbol) LF198236 uc288ytt.1 uc288ytt.1 
ENSMUST00020183488.1 Gm55113 ENSMUST00020183488.1 Gm55113 (from geneSymbol) uc288ytu.1 uc288ytu.1 
ENSMUST00020183489.1 Gm55859 ENSMUST00020183489.1 Gm55859 (from geneSymbol) uc288ytv.1 uc288ytv.1 
ENSMUST00020183490.1 Gm54534 ENSMUST00020183490.1 Gm54534 (from geneSymbol) uc288ytw.1 uc288ytw.1 
ENSMUST00020183491.1 Gm54377 ENSMUST00020183491.1 Gm54377 (from geneSymbol) uc288ytx.1 uc288ytx.1 
ENSMUST00020183492.1 Gm55789 ENSMUST00020183492.1 Gm55789 (from geneSymbol) uc288yty.1 uc288yty.1 
ENSMUST00020183493.1 Gm54786 ENSMUST00020183493.1 Gm54786 (from geneSymbol) uc288ytz.1 uc288ytz.1 
ENSMUST00020183494.1 Gm56346 ENSMUST00020183494.1 Gm56346 (from geneSymbol) uc288yua.1 uc288yua.1 
ENSMUST00020183495.1 Gm56329 ENSMUST00020183495.1 Gm56329 (from geneSymbol) uc288yub.1 uc288yub.1 
ENSMUST00020183496.1 Gm55834 ENSMUST00020183496.1 Gm55834 (from geneSymbol) uc288yuc.1 uc288yuc.1 
ENSMUST00020183497.1 Gm56020 ENSMUST00020183497.1 Gm56020 (from geneSymbol) uc288yud.1 uc288yud.1 
ENSMUST00020183498.1 Gm54740 ENSMUST00020183498.1 Gm54740 (from geneSymbol) uc288yue.1 uc288yue.1 
ENSMUST00020183499.1 Gm54516 ENSMUST00020183499.1 Gm54516 (from geneSymbol) uc288yuf.1 uc288yuf.1 
ENSMUST00020183500.1 Gm54494 ENSMUST00020183500.1 Gm54494 (from geneSymbol) uc288yug.1 uc288yug.1 
ENSMUST00020183501.1 Gm56383 ENSMUST00020183501.1 Gm56383 (from geneSymbol) uc288yuh.1 uc288yuh.1 
ENSMUST00020183502.1 Gm56129 ENSMUST00020183502.1 Gm56129 (from geneSymbol) uc288yui.1 uc288yui.1 
ENSMUST00020183503.1 Gm56418 ENSMUST00020183503.1 Gm56418 (from geneSymbol) uc288yuj.1 uc288yuj.1 
ENSMUST00020183504.1 Gm55097 ENSMUST00020183504.1 Gm55097 (from geneSymbol) uc288yuk.1 uc288yuk.1 
ENSMUST00020183505.1 Gm55058 ENSMUST00020183505.1 Gm55058 (from geneSymbol) uc288yul.1 uc288yul.1 
ENSMUST00020183506.1 Gm56194 ENSMUST00020183506.1 Gm56194 (from geneSymbol) uc288yum.1 uc288yum.1 
ENSMUST00020183507.1 Gm55560 ENSMUST00020183507.1 Gm55560 (from geneSymbol) uc288yun.1 uc288yun.1 
ENSMUST00020183508.1 Gm54975 ENSMUST00020183508.1 Gm54975 (from geneSymbol) uc288yuo.1 uc288yuo.1 
ENSMUST00020183509.1 Gm55430 ENSMUST00020183509.1 Gm55430 (from geneSymbol) uc288yup.1 uc288yup.1 
ENSMUST00020183510.1 Gm54926 ENSMUST00020183510.1 Gm54926 (from geneSymbol) uc288yuq.1 uc288yuq.1 
ENSMUST00020183511.1 Gm54450 ENSMUST00020183511.1 Gm54450 (from geneSymbol) LF199427 uc288yur.1 uc288yur.1 
ENSMUST00020183512.1 Gm55935 ENSMUST00020183512.1 Gm55935 (from geneSymbol) DQ541630 uc288yus.1 uc288yus.1 
ENSMUST00020183513.1 Gm55102 ENSMUST00020183513.1 Gm55102 (from geneSymbol) DQ541194 uc288yut.1 uc288yut.1 
ENSMUST00020183514.1 Gm56438 ENSMUST00020183514.1 Gm56438 (from geneSymbol) uc288yuu.1 uc288yuu.1 
ENSMUST00020183515.1 Gm54587 ENSMUST00020183515.1 Gm54587 (from geneSymbol) AK153385 uc288yuv.1 uc288yuv.1 
ENSMUST00020183516.1 Gm55156 ENSMUST00020183516.1 Gm55156 (from geneSymbol) uc288yuw.1 uc288yuw.1 
ENSMUST00020183517.1 Gm56352 ENSMUST00020183517.1 Gm56352 (from geneSymbol) uc288yux.1 uc288yux.1 
ENSMUST00020183518.1 Gm54604 ENSMUST00020183518.1 Gm54604 (from geneSymbol) uc288yuy.1 uc288yuy.1 
ENSMUST00020183519.1 Gm22813 ENSMUST00020183519.1 Gm22813 (from geneSymbol) uc288yuz.1 uc288yuz.1 
ENSMUST00020183520.1 Gm54340 ENSMUST00020183520.1 Gm54340 (from geneSymbol) uc288yva.1 uc288yva.1 
ENSMUST00020183521.1 Gm55313 ENSMUST00020183521.1 Gm55313 (from geneSymbol) uc288yvb.1 uc288yvb.1 
ENSMUST00020183522.1 Gm54595 ENSMUST00020183522.1 Gm54595 (from geneSymbol) uc288yvc.1 uc288yvc.1 
ENSMUST00020183523.1 Gm56133 ENSMUST00020183523.1 Gm56133 (from geneSymbol) uc288yvd.1 uc288yvd.1 
ENSMUST00020183524.1 Gm56226 ENSMUST00020183524.1 Gm56226 (from geneSymbol) LF194293 uc288yve.1 uc288yve.1 
ENSMUST00020183525.1 Gm55223 ENSMUST00020183525.1 Gm55223 (from geneSymbol) uc288yvf.1 uc288yvf.1 
ENSMUST00020183526.1 Gm55167 ENSMUST00020183526.1 Gm55167 (from geneSymbol) uc288yvg.1 uc288yvg.1 
ENSMUST00020183527.1 Gm56392 ENSMUST00020183527.1 Gm56392 (from geneSymbol) LF240867 uc288yvh.1 uc288yvh.1 
ENSMUST00020183528.1 Gm56390 ENSMUST00020183528.1 Gm56390 (from geneSymbol) uc288yvi.1 uc288yvi.1 
ENSMUST00020183529.1 Gm54433 ENSMUST00020183529.1 Gm54433 (from geneSymbol) uc288yvj.1 uc288yvj.1 
ENSMUST00020183530.1 Snord3a ENSMUST00020183530.1 Snord3a (from geneSymbol) X56029 uc288yvk.1 uc288yvk.1 
ENSMUST00020183531.1 Gm54942 ENSMUST00020183531.1 Gm54942 (from geneSymbol) uc288yvl.1 uc288yvl.1 
ENSMUST00020183532.1 Gm56441 ENSMUST00020183532.1 Gm56441 (from geneSymbol) uc288yvm.1 uc288yvm.1 
ENSMUST00020183533.1 Gm56461 ENSMUST00020183533.1 Gm56461 (from geneSymbol) uc288yvn.1 uc288yvn.1 
ENSMUST00020183534.1 Gm55073 ENSMUST00020183534.1 Gm55073 (from geneSymbol) uc288yvo.1 uc288yvo.1 
ENSMUST00020183535.1 Gm54914 ENSMUST00020183535.1 Gm54914 (from geneSymbol) uc288yvp.1 uc288yvp.1 
ENSMUST00020183536.1 Gm54702 ENSMUST00020183536.1 Gm54702 (from geneSymbol) AB352541 uc288yvq.1 uc288yvq.1 
ENSMUST00020183537.1 Gm55297 ENSMUST00020183537.1 Gm55297 (from geneSymbol) DQ311494 uc288yvr.1 uc288yvr.1 
ENSMUST00020183538.1 Gm54538 ENSMUST00020183538.1 Gm54538 (from geneSymbol) uc288yvs.1 uc288yvs.1 
ENSMUST00020183539.1 Gm55306 ENSMUST00020183539.1 Gm55306 (from geneSymbol) uc288yvt.1 uc288yvt.1 
ENSMUST00020183540.1 Gm54811 ENSMUST00020183540.1 Gm54811 (from geneSymbol) uc288yvu.1 uc288yvu.1 
ENSMUST00020183541.1 Gm55086 ENSMUST00020183541.1 Gm55086 (from geneSymbol) DQ541194 uc288yvv.1 uc288yvv.1 
ENSMUST00020183542.1 Gm54511 ENSMUST00020183542.1 Gm54511 (from geneSymbol) uc288yvw.1 uc288yvw.1 
ENSMUST00020183543.1 Gm55310 ENSMUST00020183543.1 Gm55310 (from geneSymbol) AB352500 uc288yvx.1 uc288yvx.1 
ENSMUST00020183544.1 Gm54505 ENSMUST00020183544.1 Gm54505 (from geneSymbol) uc288yvy.1 uc288yvy.1 
ENSMUST00020183545.1 Gm55354 ENSMUST00020183545.1 Gm55354 (from geneSymbol) LF193064 uc288yvz.1 uc288yvz.1 
ENSMUST00020183546.1 Gm55571 ENSMUST00020183546.1 Gm55571 (from geneSymbol) uc288ywa.1 uc288ywa.1 
ENSMUST00020183547.1 Gm54649 ENSMUST00020183547.1 Gm54649 (from geneSymbol) uc288ywb.1 uc288ywb.1 
ENSMUST00020183548.1 Gm55008 ENSMUST00020183548.1 Gm55008 (from geneSymbol) uc288ywc.1 uc288ywc.1 
ENSMUST00020183549.1 Gm55266 ENSMUST00020183549.1 Gm55266 (from geneSymbol) DQ541194 uc288ywd.1 uc288ywd.1 
ENSMUST00020183550.1 Gm55923 ENSMUST00020183550.1 Gm55923 (from geneSymbol) uc288ywe.1 uc288ywe.1 
ENSMUST00020183551.1 Gm54951 ENSMUST00020183551.1 Gm54951 (from geneSymbol) uc288ywf.1 uc288ywf.1 
ENSMUST00020183552.1 Gm55060 ENSMUST00020183552.1 Gm55060 (from geneSymbol) uc288ywg.1 uc288ywg.1 
ENSMUST00020183553.1 Gm56239 ENSMUST00020183553.1 Gm56239 (from geneSymbol) uc288ywh.1 uc288ywh.1 
ENSMUST00020183554.1 Gm54723 ENSMUST00020183554.1 Gm54723 (from geneSymbol) uc288ywi.1 uc288ywi.1 
ENSMUST00020183555.1 Gm56338 ENSMUST00020183555.1 Gm56338 (from geneSymbol) uc288ywj.1 uc288ywj.1 
ENSMUST00020183556.1 Gm54787 ENSMUST00020183556.1 Gm54787 (from geneSymbol) uc288ywk.1 uc288ywk.1 
ENSMUST00020183557.1 Gm54479 ENSMUST00020183557.1 Gm54479 (from geneSymbol) uc288ywl.1 uc288ywl.1 
ENSMUST00020183558.1 Gm55439 ENSMUST00020183558.1 Gm55439 (from geneSymbol) uc288ywm.1 uc288ywm.1 
ENSMUST00020183560.1 Gm55738 ENSMUST00020183560.1 Gm55738 (from geneSymbol) DQ311535 uc288ywo.1 uc288ywo.1 
ENSMUST00020183561.1 Gm56481 ENSMUST00020183561.1 Gm56481 (from geneSymbol) uc288ywp.1 uc288ywp.1 
ENSMUST00020183562.1 Gm55974 ENSMUST00020183562.1 Gm55974 (from geneSymbol) LF194594 uc288ywq.1 uc288ywq.1 
ENSMUST00020183563.1 Gm56453 ENSMUST00020183563.1 Gm56453 (from geneSymbol) uc288ywr.1 uc288ywr.1 
ENSMUST00020183564.1 Gm54932 ENSMUST00020183564.1 Gm54932 (from geneSymbol) uc288yws.1 uc288yws.1 
ENSMUST00020183565.1 Gm56362 ENSMUST00020183565.1 Gm56362 (from geneSymbol) uc288ywt.1 uc288ywt.1 
ENSMUST00020183566.1 Gm54343 ENSMUST00020183566.1 Gm54343 (from geneSymbol) uc288ywu.1 uc288ywu.1 
ENSMUST00020183567.1 Gm22885 ENSMUST00020183567.1 Gm22885 (from geneSymbol) uc288ywv.1 uc288ywv.1 
ENSMUST00020183568.1 Gm55568 ENSMUST00020183568.1 Gm55568 (from geneSymbol) uc288yww.1 uc288yww.1 
ENSMUST00020183569.1 Gm55453 ENSMUST00020183569.1 Gm55453 (from geneSymbol) uc288ywx.1 uc288ywx.1 
ENSMUST00020183570.1 Gm54877 ENSMUST00020183570.1 Gm54877 (from geneSymbol) uc288ywy.1 uc288ywy.1 
ENSMUST00020183571.1 Gm56262 ENSMUST00020183571.1 Gm56262 (from geneSymbol) DQ311494 uc288ywz.1 uc288ywz.1 
ENSMUST00020183572.1 Gm56306 ENSMUST00020183572.1 Gm56306 (from geneSymbol) uc288yxa.1 uc288yxa.1 
ENSMUST00020183573.1 Gm55817 ENSMUST00020183573.1 Gm55817 (from geneSymbol) uc288yxb.1 uc288yxb.1 
ENSMUST00020183574.1 Gm54889 ENSMUST00020183574.1 Gm54889 (from geneSymbol) uc288yxc.1 uc288yxc.1 
ENSMUST00020183575.1 Gm55037 ENSMUST00020183575.1 Gm55037 (from geneSymbol) uc288yxd.1 uc288yxd.1 
ENSMUST00020183576.1 Gm55771 ENSMUST00020183576.1 Gm55771 (from geneSymbol) DQ311494 uc288yxe.1 uc288yxe.1 
ENSMUST00020183577.1 Gm56475 ENSMUST00020183577.1 Gm56475 (from geneSymbol) LF193303 uc288yxf.1 uc288yxf.1 
ENSMUST00020183578.1 Gm55566 ENSMUST00020183578.1 Gm55566 (from geneSymbol) uc288yxg.1 uc288yxg.1 
ENSMUST00020183579.1 Gm55928 ENSMUST00020183579.1 Gm55928 (from geneSymbol) uc288yxh.1 uc288yxh.1 
ENSMUST00020183580.1 Gm56022 ENSMUST00020183580.1 Gm56022 (from geneSymbol) uc288yxi.1 uc288yxi.1 
ENSMUST00020183581.1 Gm54907 ENSMUST00020183581.1 Gm54907 (from geneSymbol) uc288yxj.1 uc288yxj.1 
ENSMUST00020183582.1 Gm55432 ENSMUST00020183582.1 Gm55432 (from geneSymbol) uc288yxk.1 uc288yxk.1 
ENSMUST00020183583.1 Gm55403 ENSMUST00020183583.1 Gm55403 (from geneSymbol) uc288yxl.1 uc288yxl.1 
ENSMUST00020183584.1 Gm54693 ENSMUST00020183584.1 Gm54693 (from geneSymbol) uc288yxm.1 uc288yxm.1 
ENSMUST00020183585.1 Gm56292 ENSMUST00020183585.1 Gm56292 (from geneSymbol) uc288yxn.1 uc288yxn.1 
ENSMUST00020183586.1 Gm55569 ENSMUST00020183586.1 Gm55569 (from geneSymbol) uc288yxo.1 uc288yxo.1 
ENSMUST00020183587.1 Gm56122 ENSMUST00020183587.1 Gm56122 (from geneSymbol) uc288yxp.1 uc288yxp.1 
ENSMUST00020183588.1 Gm55294 ENSMUST00020183588.1 Gm55294 (from geneSymbol) uc288yxq.1 uc288yxq.1 
ENSMUST00020183589.1 Gm54351 ENSMUST00020183589.1 Gm54351 (from geneSymbol) AB352541 uc288yxr.1 uc288yxr.1 
ENSMUST00020183590.1 Gm55944 ENSMUST00020183590.1 Gm55944 (from geneSymbol) uc288yxs.1 uc288yxs.1 
ENSMUST00020183591.1 Gm55221 ENSMUST00020183591.1 Gm55221 (from geneSymbol) DQ311494 uc288yxt.1 uc288yxt.1 
ENSMUST00020183592.1 Gm55227 ENSMUST00020183592.1 Gm55227 (from geneSymbol) AB351420 uc288yxu.1 uc288yxu.1 
ENSMUST00020183593.1 Gm56415 ENSMUST00020183593.1 Gm56415 (from geneSymbol) LF193787 uc288yxv.1 uc288yxv.1 
ENSMUST00020183594.1 Gm56218 ENSMUST00020183594.1 Gm56218 (from geneSymbol) uc288yxw.1 uc288yxw.1 
ENSMUST00020183595.1 Gm54950 ENSMUST00020183595.1 Gm54950 (from geneSymbol) uc288yxx.1 uc288yxx.1 
ENSMUST00020183596.1 Gm55766 ENSMUST00020183596.1 Gm55766 (from geneSymbol) uc288yxy.1 uc288yxy.1 
ENSMUST00020183597.1 Gm54577 ENSMUST00020183597.1 Gm54577 (from geneSymbol) uc288yxz.1 uc288yxz.1 
ENSMUST00020183598.1 AF357425 ENSMUST00020183598.1 snoRNA AF357425 (from RefSeq NR_046302.1) NR_046302 uc288yya.1 uc288yya.1 
ENSMUST00020183599.1 Gm54630 ENSMUST00020183599.1 Gm54630 (from geneSymbol) uc288yyb.1 uc288yyb.1 
ENSMUST00020183600.1 Gm56083 ENSMUST00020183600.1 Gm56083 (from geneSymbol) uc288yyc.1 uc288yyc.1 
ENSMUST00020183601.1 Gm55021 ENSMUST00020183601.1 Gm55021 (from geneSymbol) AB351420 uc288yyd.1 uc288yyd.1 
ENSMUST00020183602.1 Gm55126 ENSMUST00020183602.1 Gm55126 (from geneSymbol) uc288yye.1 uc288yye.1 
ENSMUST00020183603.1 Gm54403 ENSMUST00020183603.1 Gm54403 (from geneSymbol) AB352978 uc288yyf.1 uc288yyf.1 
ENSMUST00020183604.1 Gm55735 ENSMUST00020183604.1 Gm55735 (from geneSymbol) uc288yyg.1 uc288yyg.1 
ENSMUST00020183605.1 Gm55899 ENSMUST00020183605.1 Gm55899 (from geneSymbol) uc288yyh.1 uc288yyh.1 
ENSMUST00020183606.1 Gm54585 ENSMUST00020183606.1 Gm54585 (from geneSymbol) uc288yyi.1 uc288yyi.1 
ENSMUST00020183607.1 Gm55299 ENSMUST00020183607.1 Gm55299 (from geneSymbol) DQ311494 uc288yyj.1 uc288yyj.1 
ENSMUST00020183608.1 Gm55964 ENSMUST00020183608.1 Gm55964 (from geneSymbol) uc288yyk.1 uc288yyk.1 
ENSMUST00020183609.1 Gm54468 ENSMUST00020183609.1 Gm54468 (from geneSymbol) uc288yyl.1 uc288yyl.1 
ENSMUST00020183610.1 Gm54979 ENSMUST00020183610.1 Gm54979 (from geneSymbol) uc288yym.1 uc288yym.1 
ENSMUST00020183611.1 Gm55489 ENSMUST00020183611.1 Gm55489 (from geneSymbol) uc288yyn.1 uc288yyn.1 
ENSMUST00020183612.1 Gm55129 ENSMUST00020183612.1 Gm55129 (from geneSymbol) uc288yyo.1 uc288yyo.1 
ENSMUST00020183613.1 Gm55985 ENSMUST00020183613.1 Gm55985 (from geneSymbol) uc288yyp.1 uc288yyp.1 
ENSMUST00020183614.1 Gm56238 ENSMUST00020183614.1 Gm56238 (from geneSymbol) uc288yyq.1 uc288yyq.1 
ENSMUST00020183615.1 Gm56373 ENSMUST00020183615.1 Gm56373 (from geneSymbol) uc288yyr.1 uc288yyr.1 
ENSMUST00020183616.1 Gm54841 ENSMUST00020183616.1 Gm54841 (from geneSymbol) AB351420 uc288yys.1 uc288yys.1 
ENSMUST00020183617.1 Gm54500 ENSMUST00020183617.1 Gm54500 (from geneSymbol) uc288yyt.1 uc288yyt.1 
ENSMUST00020183618.1 Gm54427 ENSMUST00020183618.1 Gm54427 (from geneSymbol) LF200274 uc288yyu.1 uc288yyu.1 
ENSMUST00020183619.1 Gm56198 ENSMUST00020183619.1 Gm56198 (from geneSymbol) uc288yyv.1 uc288yyv.1 
ENSMUST00020183620.1 Gm56015 ENSMUST00020183620.1 Gm56015 (from geneSymbol) uc288yyw.1 uc288yyw.1 
ENSMUST00020183621.1 Gm56265 ENSMUST00020183621.1 Gm56265 (from geneSymbol) uc288yyx.1 uc288yyx.1 
ENSMUST00020183622.1 Gm54738 ENSMUST00020183622.1 Gm54738 (from geneSymbol) uc288yyy.1 uc288yyy.1 
ENSMUST00020183623.1 Gm56203 ENSMUST00020183623.1 Gm56203 (from geneSymbol) uc288yyz.1 uc288yyz.1 
ENSMUST00020183624.1 Gm54815 ENSMUST00020183624.1 Gm54815 (from geneSymbol) uc288yza.1 uc288yza.1 
ENSMUST00020183625.1 Gm55334 ENSMUST00020183625.1 Gm55334 (from geneSymbol) uc288yzb.1 uc288yzb.1 
ENSMUST00020183626.1 Gm54388 ENSMUST00020183626.1 Gm54388 (from geneSymbol) uc288yzc.1 uc288yzc.1 
ENSMUST00020183627.1 Gm55788 ENSMUST00020183627.1 Gm55788 (from geneSymbol) uc288yzd.1 uc288yzd.1 
ENSMUST00020183628.1 Gm54922 ENSMUST00020183628.1 Gm54922 (from geneSymbol) LF200564 uc288yze.1 uc288yze.1 
ENSMUST00020183629.1 Gm55712 ENSMUST00020183629.1 Gm55712 (from geneSymbol) uc288yzf.1 uc288yzf.1 
ENSMUST00020183630.1 Gm54375 ENSMUST00020183630.1 Gm54375 (from geneSymbol) uc288yzg.1 uc288yzg.1 
ENSMUST00020183631.1 Gm56043 ENSMUST00020183631.1 Gm56043 (from geneSymbol) uc288yzh.1 uc288yzh.1 
ENSMUST00020183632.1 Gm55422 ENSMUST00020183632.1 Gm55422 (from geneSymbol) uc288yzi.1 uc288yzi.1 
ENSMUST00020183633.1 Gm56483 ENSMUST00020183633.1 Gm56483 (from geneSymbol) uc288yzj.1 uc288yzj.1 
ENSMUST00020183634.1 Gm55820 ENSMUST00020183634.1 Gm55820 (from geneSymbol) LF193522 uc288yzk.1 uc288yzk.1 
ENSMUST00020183635.1 Gm54959 ENSMUST00020183635.1 Gm54959 (from geneSymbol) uc288yzl.1 uc288yzl.1 
ENSMUST00020183636.1 Gm56332 ENSMUST00020183636.1 Gm56332 (from geneSymbol) uc288yzm.1 uc288yzm.1 
ENSMUST00020183637.1 Gm56030 ENSMUST00020183637.1 Gm56030 (from geneSymbol) AB349740 uc288yzn.1 uc288yzn.1 
ENSMUST00020183638.1 Gm56211 ENSMUST00020183638.1 Gm56211 (from geneSymbol) uc288yzo.1 uc288yzo.1 
ENSMUST00020183639.1 Gm55918 ENSMUST00020183639.1 Gm55918 (from geneSymbol) uc288yzp.1 uc288yzp.1 
ENSMUST00020183640.1 Gm54899 ENSMUST00020183640.1 Gm54899 (from geneSymbol) uc288yzq.1 uc288yzq.1 
ENSMUST00020183641.1 Gm55116 ENSMUST00020183641.1 Gm55116 (from geneSymbol) uc288yzr.1 uc288yzr.1 
ENSMUST00020183642.1 Gm54597 ENSMUST00020183642.1 Gm54597 (from geneSymbol) uc288yzs.1 uc288yzs.1 
ENSMUST00020183643.1 Gm56186 ENSMUST00020183643.1 Gm56186 (from geneSymbol) uc288yzt.1 uc288yzt.1 
ENSMUST00020183644.1 Gm54827 ENSMUST00020183644.1 Gm54827 (from geneSymbol) uc288yzu.1 uc288yzu.1 
ENSMUST00020183645.1 Gm55322 ENSMUST00020183645.1 Gm55322 (from geneSymbol) uc288yzv.1 uc288yzv.1 
ENSMUST00020183646.1 Gm56309 ENSMUST00020183646.1 Gm56309 (from geneSymbol) uc288yzw.1 uc288yzw.1 
ENSMUST00020183647.1 Gm55015 ENSMUST00020183647.1 Gm55015 (from geneSymbol) DQ311494 uc288yzx.1 uc288yzx.1 
ENSMUST00020183648.1 Gm54870 ENSMUST00020183648.1 Gm54870 (from geneSymbol) AB350056 uc288yzy.1 uc288yzy.1 
ENSMUST00020183649.1 Gm55143 ENSMUST00020183649.1 Gm55143 (from geneSymbol) AB352500 uc288yzz.1 uc288yzz.1 
ENSMUST00020183650.1 Gm54916 ENSMUST00020183650.1 Gm54916 (from geneSymbol) uc288zaa.1 uc288zaa.1 
ENSMUST00020183651.1 Gm56116 ENSMUST00020183651.1 Gm56116 (from geneSymbol) uc288zab.1 uc288zab.1 
ENSMUST00020183652.1 Gm54868 ENSMUST00020183652.1 Gm54868 (from geneSymbol) uc288zac.1 uc288zac.1 
ENSMUST00020183653.1 Gm55257 ENSMUST00020183653.1 Gm55257 (from geneSymbol) uc288zad.1 uc288zad.1 
ENSMUST00020183654.1 Gm55023 ENSMUST00020183654.1 Gm55023 (from geneSymbol) uc288zae.1 uc288zae.1 
ENSMUST00020183655.1 Gm55665 ENSMUST00020183655.1 Gm55665 (from geneSymbol) LF196768 uc288zaf.1 uc288zaf.1 
ENSMUST00020183656.1 Gm56467 ENSMUST00020183656.1 Gm56467 (from geneSymbol) uc288zag.1 uc288zag.1 
ENSMUST00020183657.1 Gm55546 ENSMUST00020183657.1 Gm55546 (from geneSymbol) uc288zah.1 uc288zah.1 
ENSMUST00020183658.1 Gm56102 ENSMUST00020183658.1 Gm56102 (from geneSymbol) LF197686 uc288zai.1 uc288zai.1 
ENSMUST00020183659.1 Gm54618 ENSMUST00020183659.1 Gm54618 (from geneSymbol) uc288zaj.1 uc288zaj.1 
ENSMUST00020183660.1 Gm55866 ENSMUST00020183660.1 Gm55866 (from geneSymbol) uc288zak.1 uc288zak.1 
ENSMUST00020183661.1 Gm54545 ENSMUST00020183661.1 Gm54545 (from geneSymbol) LF195683 uc288zal.1 uc288zal.1 
ENSMUST00020183662.1 Gm56208 ENSMUST00020183662.1 Gm56208 (from geneSymbol) LF198119 uc288zam.1 uc288zam.1 
ENSMUST00020183663.1 Gm55757 ENSMUST00020183663.1 Gm55757 (from geneSymbol) uc288zan.1 uc288zan.1 
ENSMUST00020183664.1 Gm54804 ENSMUST00020183664.1 Gm54804 (from geneSymbol) uc288zao.1 uc288zao.1 
ENSMUST00020183665.1 Gm55482 ENSMUST00020183665.1 Gm55482 (from geneSymbol) uc288zap.1 uc288zap.1 
ENSMUST00020183666.1 Gm55399 ENSMUST00020183666.1 Gm55399 (from geneSymbol) uc288zaq.1 uc288zaq.1 
ENSMUST00020183667.1 Gm55991 ENSMUST00020183667.1 Gm55991 (from geneSymbol) uc288zar.1 uc288zar.1 
ENSMUST00020183668.1 Gm55874 ENSMUST00020183668.1 Gm55874 (from geneSymbol) uc288zas.1 uc288zas.1 
ENSMUST00020183669.1 Gm56282 ENSMUST00020183669.1 Gm56282 (from geneSymbol) uc288zat.1 uc288zat.1 
ENSMUST00020183670.1 Gm55211 ENSMUST00020183670.1 Gm55211 (from geneSymbol) uc288zau.1 uc288zau.1 
ENSMUST00020183671.1 Gm55314 ENSMUST00020183671.1 Gm55314 (from geneSymbol) uc288zav.1 uc288zav.1 
ENSMUST00020183672.1 Gm55977 ENSMUST00020183672.1 Gm55977 (from geneSymbol) uc288zaw.1 uc288zaw.1 
ENSMUST00020183673.1 Gm55280 ENSMUST00020183673.1 Gm55280 (from geneSymbol) uc288zax.1 uc288zax.1 
ENSMUST00020183674.1 Gm55046 ENSMUST00020183674.1 Gm55046 (from geneSymbol) uc288zay.1 uc288zay.1 
ENSMUST00020183675.1 Gm56363 ENSMUST00020183675.1 Gm56363 (from geneSymbol) DQ311497 uc288zaz.1 uc288zaz.1 
ENSMUST00020183676.1 Gm55999 ENSMUST00020183676.1 Gm55999 (from geneSymbol) DQ541194 uc288zba.1 uc288zba.1 
ENSMUST00020183677.1 Gm54747 ENSMUST00020183677.1 Gm54747 (from geneSymbol) uc288zbb.1 uc288zbb.1 
ENSMUST00020183678.1 Gm54367 ENSMUST00020183678.1 Gm54367 (from geneSymbol) DQ311494 uc288zbc.1 uc288zbc.1 
ENSMUST00020183679.1 Gm55900 ENSMUST00020183679.1 Gm55900 (from geneSymbol) LF195826 uc288zbd.1 uc288zbd.1 
ENSMUST00020183680.1 Gm54898 ENSMUST00020183680.1 Gm54898 (from geneSymbol) uc288zbe.1 uc288zbe.1 
ENSMUST00020183681.1 Gm56460 ENSMUST00020183681.1 Gm56460 (from geneSymbol) LF193281 uc288zbf.1 uc288zbf.1 
ENSMUST00020183682.1 Gm55879 ENSMUST00020183682.1 Gm55879 (from geneSymbol) uc288zbg.1 uc288zbg.1 
ENSMUST00020183683.1 Gm55155 ENSMUST00020183683.1 Gm55155 (from geneSymbol) LF202100 uc288zbh.1 uc288zbh.1 
ENSMUST00020183684.1 Gm55829 ENSMUST00020183684.1 Gm55829 (from geneSymbol) uc288zbi.1 uc288zbi.1 
ENSMUST00020183685.1 Gm56039 ENSMUST00020183685.1 Gm56039 (from geneSymbol) uc288zbj.1 uc288zbj.1 
ENSMUST00020183686.1 Gm55356 ENSMUST00020183686.1 Gm55356 (from geneSymbol) uc288zbk.1 uc288zbk.1 
ENSMUST00020183687.1 Gm55026 ENSMUST00020183687.1 Gm55026 (from geneSymbol) uc288zbl.1 uc288zbl.1 
ENSMUST00020183688.1 Gm56310 ENSMUST00020183688.1 Gm56310 (from geneSymbol) uc288zbm.1 uc288zbm.1 
ENSMUST00020183689.1 Gm55029 ENSMUST00020183689.1 Gm55029 (from geneSymbol) uc288zbn.1 uc288zbn.1 
ENSMUST00020183690.1 Gm56243 ENSMUST00020183690.1 Gm56243 (from geneSymbol) DQ311494 uc288zbo.1 uc288zbo.1 
ENSMUST00020183691.1 Gm55307 ENSMUST00020183691.1 Gm55307 (from geneSymbol) uc288zbp.1 uc288zbp.1 
ENSMUST00020183692.1 Gm56201 ENSMUST00020183692.1 Gm56201 (from geneSymbol) uc288zbq.1 uc288zbq.1 
ENSMUST00020183693.1 Gm56331 ENSMUST00020183693.1 Gm56331 (from geneSymbol) uc288zbr.1 uc288zbr.1 
ENSMUST00020183694.1 Gm55481 ENSMUST00020183694.1 Gm55481 (from geneSymbol) uc288zbs.1 uc288zbs.1 
ENSMUST00020183695.1 Gm55776 ENSMUST00020183695.1 Gm55776 (from geneSymbol) uc288zbt.1 uc288zbt.1 
ENSMUST00020183696.1 Gm54676 ENSMUST00020183696.1 Gm54676 (from geneSymbol) uc288zbu.1 uc288zbu.1 
ENSMUST00020183697.1 Gm56159 ENSMUST00020183697.1 Gm56159 (from geneSymbol) uc288zbv.1 uc288zbv.1 
ENSMUST00020183698.1 Gm55271 ENSMUST00020183698.1 Gm55271 (from geneSymbol) DQ311494 uc288zbw.1 uc288zbw.1 
ENSMUST00020183699.1 Gm56471 ENSMUST00020183699.1 Gm56471 (from geneSymbol) uc288zbx.1 uc288zbx.1 
ENSMUST00020183700.1 Gm54894 ENSMUST00020183700.1 Gm54894 (from geneSymbol) uc288zby.1 uc288zby.1 
ENSMUST00020183701.1 Gm55180 ENSMUST00020183701.1 Gm55180 (from geneSymbol) DQ311494 uc288zbz.1 uc288zbz.1 
ENSMUST00020183702.1 Gm55676 ENSMUST00020183702.1 Gm55676 (from geneSymbol) uc288zca.1 uc288zca.1 
ENSMUST00020183703.1 Gm54548 ENSMUST00020183703.1 Gm54548 (from geneSymbol) AB352978 uc288zcb.1 uc288zcb.1 
ENSMUST00020183704.1 Gm54972 ENSMUST00020183704.1 Gm54972 (from geneSymbol) uc288zcc.1 uc288zcc.1 
ENSMUST00020183705.1 Gm54744 ENSMUST00020183705.1 Gm54744 (from geneSymbol) uc288zcd.1 uc288zcd.1 
ENSMUST00020183706.1 Gm56026 ENSMUST00020183706.1 Gm56026 (from geneSymbol) LF193346 uc288zce.1 uc288zce.1 
ENSMUST00020183707.1 Gm55173 ENSMUST00020183707.1 Gm55173 (from geneSymbol) uc288zcf.1 uc288zcf.1 
ENSMUST00020183708.1 Gm56368 ENSMUST00020183708.1 Gm56368 (from geneSymbol) uc288zcg.1 uc288zcg.1 
ENSMUST00020183709.1 Gm55327 ENSMUST00020183709.1 Gm55327 (from geneSymbol) uc288zch.1 uc288zch.1 
ENSMUST00020183710.1 Gm55343 ENSMUST00020183710.1 Gm55343 (from geneSymbol) uc288zci.1 uc288zci.1 
ENSMUST00020183711.1 Gm55474 ENSMUST00020183711.1 Gm55474 (from geneSymbol) uc288zcj.1 uc288zcj.1 
ENSMUST00020183712.1 Gm56357 ENSMUST00020183712.1 Gm56357 (from geneSymbol) DQ311494 uc288zck.1 uc288zck.1 
ENSMUST00020183713.1 Gm56219 ENSMUST00020183713.1 Gm56219 (from geneSymbol) uc288zcl.1 uc288zcl.1 
ENSMUST00020183714.1 Gm56377 ENSMUST00020183714.1 Gm56377 (from geneSymbol) uc288zcm.1 uc288zcm.1 
ENSMUST00020183715.1 Gm55542 ENSMUST00020183715.1 Gm55542 (from geneSymbol) uc288zcn.1 uc288zcn.1 
ENSMUST00020183716.1 Gm54612 ENSMUST00020183716.1 Gm54612 (from geneSymbol) uc288zco.1 uc288zco.1 
ENSMUST00020183717.1 Gm55020 ENSMUST00020183717.1 Gm55020 (from geneSymbol) uc288zcp.1 uc288zcp.1 
ENSMUST00020183718.1 Gm55316 ENSMUST00020183718.1 Gm55316 (from geneSymbol) uc288zcq.1 uc288zcq.1 
ENSMUST00020183719.1 Gm55901 ENSMUST00020183719.1 Gm55901 (from geneSymbol) uc288zcr.1 uc288zcr.1 
ENSMUST00020183720.1 Gm54493 ENSMUST00020183720.1 Gm54493 (from geneSymbol) uc288zcs.1 uc288zcs.1 
ENSMUST00020183721.1 Gm56142 ENSMUST00020183721.1 Gm56142 (from geneSymbol) uc288zct.1 uc288zct.1 
ENSMUST00020183722.1 Gm55822 ENSMUST00020183722.1 Gm55822 (from geneSymbol) uc288zcu.1 uc288zcu.1 
ENSMUST00020183723.1 Gm55119 ENSMUST00020183723.1 Gm55119 (from geneSymbol) uc288zcv.1 uc288zcv.1 
ENSMUST00020183724.1 Gm54348 ENSMUST00020183724.1 Gm54348 (from geneSymbol) uc288zcw.1 uc288zcw.1 
ENSMUST00020183725.1 Gm54426 ENSMUST00020183725.1 Gm54426 (from geneSymbol) AF357408 uc288zcx.1 uc288zcx.1 
ENSMUST00020183726.1 Gm55380 ENSMUST00020183726.1 Gm55380 (from geneSymbol) LF302648 uc288zcy.1 uc288zcy.1 
ENSMUST00020183727.1 Gm56270 ENSMUST00020183727.1 Gm56270 (from geneSymbol) DQ311497 uc288zcz.1 uc288zcz.1 
ENSMUST00020183728.1 Gm55103 ENSMUST00020183728.1 Gm55103 (from geneSymbol) uc288zda.1 uc288zda.1 
ENSMUST00020183729.1 Gm54651 ENSMUST00020183729.1 Gm54651 (from geneSymbol) uc288zdb.1 uc288zdb.1 
ENSMUST00020183730.1 Gm55907 ENSMUST00020183730.1 Gm55907 (from geneSymbol) uc288zdc.1 uc288zdc.1 
ENSMUST00020183731.1 Gm56161 ENSMUST00020183731.1 Gm56161 (from geneSymbol) uc288zdd.1 uc288zdd.1 
ENSMUST00020183732.1 Gm55371 ENSMUST00020183732.1 Gm55371 (from geneSymbol) uc288zde.1 uc288zde.1 
ENSMUST00020183733.1 Gm56449 ENSMUST00020183733.1 Gm56449 (from geneSymbol) uc288zdf.1 uc288zdf.1 
ENSMUST00020183734.1 Gm54593 ENSMUST00020183734.1 Gm54593 (from geneSymbol) uc288zdg.1 uc288zdg.1 
ENSMUST00020183735.1 Gm56032 ENSMUST00020183735.1 Gm56032 (from geneSymbol) uc288zdh.1 uc288zdh.1 
ENSMUST00020183736.1 Gm56157 ENSMUST00020183736.1 Gm56157 (from geneSymbol) uc288zdi.1 uc288zdi.1 
ENSMUST00020183737.1 Gm55893 ENSMUST00020183737.1 Gm55893 (from geneSymbol) uc288zdj.1 uc288zdj.1 
ENSMUST00020183738.1 Gm56323 ENSMUST00020183738.1 Gm56323 (from geneSymbol) uc288zdk.1 uc288zdk.1 
ENSMUST00020183739.1 Gm56358 ENSMUST00020183739.1 Gm56358 (from geneSymbol) uc288zdl.1 uc288zdl.1 
ENSMUST00020183740.1 Gm54514 ENSMUST00020183740.1 Gm54514 (from geneSymbol) uc288zdm.1 uc288zdm.1 
ENSMUST00020183741.1 Gm55326 ENSMUST00020183741.1 Gm55326 (from geneSymbol) uc288zdn.1 uc288zdn.1 
ENSMUST00020183742.1 Gm56385 ENSMUST00020183742.1 Gm56385 (from geneSymbol) uc288zdo.1 uc288zdo.1 
ENSMUST00020183743.1 Gm55755 ENSMUST00020183743.1 Gm55755 (from geneSymbol) uc288zdp.1 uc288zdp.1 
ENSMUST00020183744.1 Gm54644 ENSMUST00020183744.1 Gm54644 (from geneSymbol) uc288zdq.1 uc288zdq.1 
ENSMUST00020183745.1 Gm55565 ENSMUST00020183745.1 Gm55565 (from geneSymbol) uc288zdr.1 uc288zdr.1 
ENSMUST00020183746.1 Gm54672 ENSMUST00020183746.1 Gm54672 (from geneSymbol) BC172600 uc288zds.1 uc288zds.1 
ENSMUST00020183747.1 Gm55640 ENSMUST00020183747.1 Gm55640 (from geneSymbol) DQ543817 uc288zdt.1 uc288zdt.1 
ENSMUST00020183748.1 Gm55690 ENSMUST00020183748.1 Gm55690 (from geneSymbol) uc288zdu.1 uc288zdu.1 
ENSMUST00020183749.1 Gm55785 ENSMUST00020183749.1 Gm55785 (from geneSymbol) uc288zdv.1 uc288zdv.1 
ENSMUST00020183750.1 Gm54501 ENSMUST00020183750.1 Gm54501 (from geneSymbol) uc288zdw.1 uc288zdw.1 
ENSMUST00020183751.1 Gm56062 ENSMUST00020183751.1 Gm56062 (from geneSymbol) uc288zdx.1 uc288zdx.1 
ENSMUST00020183752.1 Gm54961 ENSMUST00020183752.1 Gm54961 (from geneSymbol) uc288zdy.1 uc288zdy.1 
ENSMUST00020183753.1 Gm55498 ENSMUST00020183753.1 Gm55498 (from geneSymbol) uc288zdz.1 uc288zdz.1 
ENSMUST00020183754.1 Gm56482 ENSMUST00020183754.1 Gm56482 (from geneSymbol) uc288zea.1 uc288zea.1 
ENSMUST00020183755.1 Gm55458 ENSMUST00020183755.1 Gm55458 (from geneSymbol) FR668229 uc288zeb.1 uc288zeb.1 
ENSMUST00020183756.1 Gm55348 ENSMUST00020183756.1 Gm55348 (from geneSymbol) DQ311494 uc288zec.1 uc288zec.1 
ENSMUST00020183757.1 Gm54540 ENSMUST00020183757.1 Gm54540 (from geneSymbol) uc288zed.1 uc288zed.1 
ENSMUST00020183758.1 Gm55005 ENSMUST00020183758.1 Gm55005 (from geneSymbol) uc288zee.1 uc288zee.1 
ENSMUST00020183759.1 Gm56163 ENSMUST00020183759.1 Gm56163 (from geneSymbol) DQ541194 uc288zef.1 uc288zef.1 
ENSMUST00020183760.1 Gm55798 ENSMUST00020183760.1 Gm55798 (from geneSymbol) uc288zeg.1 uc288zeg.1 
ENSMUST00020183761.1 Gm54650 ENSMUST00020183761.1 Gm54650 (from geneSymbol) uc288zeh.1 uc288zeh.1 
ENSMUST00020183762.1 Gm54529 ENSMUST00020183762.1 Gm54529 (from geneSymbol) uc288zei.1 uc288zei.1 
ENSMUST00020183763.1 Gm55178 ENSMUST00020183763.1 Gm55178 (from geneSymbol) uc288zej.1 uc288zej.1 
ENSMUST00020183765.1 Gm56173 ENSMUST00020183765.1 Gm56173 (from geneSymbol) uc288zel.1 uc288zel.1 
ENSMUST00020183766.1 Gm54742 ENSMUST00020183766.1 Gm54742 (from geneSymbol) uc288zem.1 uc288zem.1 
ENSMUST00020183767.1 Gm55906 ENSMUST00020183767.1 Gm55906 (from geneSymbol) uc288zen.1 uc288zen.1 
ENSMUST00020183768.1 Gm54662 ENSMUST00020183768.1 Gm54662 (from geneSymbol) uc288zeo.1 uc288zeo.1 
ENSMUST00020183769.1 Gm54404 ENSMUST00020183769.1 Gm54404 (from geneSymbol) FR668218 uc288zep.1 uc288zep.1 
ENSMUST00020183770.1 Gm23604 ENSMUST00020183770.1 Gm23604 (from geneSymbol) uc288zeq.1 uc288zeq.1 
ENSMUST00020183772.1 Gm54648 ENSMUST00020183772.1 Gm54648 (from geneSymbol) uc288zes.1 uc288zes.1 
ENSMUST00020183773.1 Gm54986 ENSMUST00020183773.1 Gm54986 (from geneSymbol) LF204688 uc288zet.1 uc288zet.1 
ENSMUST00020183774.1 Gm54550 ENSMUST00020183774.1 Gm54550 (from geneSymbol) uc288zeu.1 uc288zeu.1 
ENSMUST00020183775.1 Gm55955 ENSMUST00020183775.1 Gm55955 (from geneSymbol) DQ311494 uc288zev.1 uc288zev.1 
ENSMUST00020183776.1 Gm25730 ENSMUST00020183776.1 Gm25730 (from geneSymbol) uc288zew.1 uc288zew.1 
ENSMUST00020183777.1 Gm55992 ENSMUST00020183777.1 Gm55992 (from geneSymbol) uc288zex.1 uc288zex.1 
ENSMUST00020183778.1 Gm55053 ENSMUST00020183778.1 Gm55053 (from geneSymbol) DQ311497 uc288zey.1 uc288zey.1 
ENSMUST00020183779.1 Gm54725 ENSMUST00020183779.1 Gm54725 (from geneSymbol) uc288zez.1 uc288zez.1 
ENSMUST00020183780.1 Gm55633 ENSMUST00020183780.1 Gm55633 (from geneSymbol) uc288zfa.1 uc288zfa.1 
ENSMUST00020183781.1 Gm55187 ENSMUST00020183781.1 Gm55187 (from geneSymbol) uc288zfb.1 uc288zfb.1 
ENSMUST00020183782.1 Gm54910 ENSMUST00020183782.1 Gm54910 (from geneSymbol) uc288zfc.1 uc288zfc.1 
ENSMUST00020183783.1 Gm55454 ENSMUST00020183783.1 Gm55454 (from geneSymbol) uc288zfd.1 uc288zfd.1 
ENSMUST00020183784.1 Gm55869 ENSMUST00020183784.1 Gm55869 (from geneSymbol) uc288zfe.1 uc288zfe.1 
ENSMUST00020183785.1 Gm55942 ENSMUST00020183785.1 Gm55942 (from geneSymbol) AB352500 uc288zff.1 uc288zff.1 
ENSMUST00020183786.1 Gm55197 ENSMUST00020183786.1 Gm55197 (from geneSymbol) uc288zfg.1 uc288zfg.1 
ENSMUST00020183787.1 Gm55002 ENSMUST00020183787.1 Gm55002 (from geneSymbol) uc288zfh.1 uc288zfh.1 
ENSMUST00020183788.1 Gm54544 ENSMUST00020183788.1 Gm54544 (from geneSymbol) uc288zfi.1 uc288zfi.1 
ENSMUST00020183789.1 Gm55123 ENSMUST00020183789.1 Gm55123 (from geneSymbol) AB351420 uc288zfj.1 uc288zfj.1 
ENSMUST00020183790.1 Gm55917 ENSMUST00020183790.1 Gm55917 (from geneSymbol) uc288zfk.1 uc288zfk.1 
ENSMUST00020183791.1 Gm56195 ENSMUST00020183791.1 Gm56195 (from geneSymbol) uc288zfl.1 uc288zfl.1 
ENSMUST00020183792.1 Gm56240 ENSMUST00020183792.1 Gm56240 (from geneSymbol) uc288zfm.1 uc288zfm.1 
ENSMUST00020183793.1 Gm55264 ENSMUST00020183793.1 Gm55264 (from geneSymbol) uc288zfn.1 uc288zfn.1 
ENSMUST00020183794.1 Gm55729 ENSMUST00020183794.1 Gm55729 (from geneSymbol) uc288zfo.1 uc288zfo.1 
ENSMUST00020183795.1 Gm54646 ENSMUST00020183795.1 Gm54646 (from geneSymbol) uc288zfp.1 uc288zfp.1 
ENSMUST00020183796.1 Gm55372 ENSMUST00020183796.1 Gm55372 (from geneSymbol) uc288zfq.1 uc288zfq.1 
ENSMUST00020183797.1 Gm54400 ENSMUST00020183797.1 Gm54400 (from geneSymbol) uc288zfr.1 uc288zfr.1 
ENSMUST00020183798.1 Gm55090 ENSMUST00020183798.1 Gm55090 (from geneSymbol) uc288zfs.1 uc288zfs.1 
ENSMUST00020183799.1 Gm55108 ENSMUST00020183799.1 Gm55108 (from geneSymbol) LF199329 uc288zft.1 uc288zft.1 
ENSMUST00020183800.1 Gm54946 ENSMUST00020183800.1 Gm54946 (from geneSymbol) uc288zfu.1 uc288zfu.1 
ENSMUST00020183801.1 Gm56290 ENSMUST00020183801.1 Gm56290 (from geneSymbol) uc288zfv.1 uc288zfv.1 
ENSMUST00020183805.1 Axin1 ENSMUST00020183805.1 axin 1, transcript variant 5 (from RefSeq NM_001394389.1) AXIN1_MOUSE Axin Fu NM_001394389 O35625 uc315wrt.1 Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. Homodimer (PubMed:17681137). Component of the beta-catenin destruction complex, containing at least CTNNB1, an axin and GSK3B, that regulates CTNNB1 protein levels through phosphorylation and ubiquitination (By similarity). Interacts with GSK3B; the interaction hyperphosphorylates CTNNB1 leading to its ubiquitination and destruction (By similarity). Interacts with DAXX; the interaction stimulates the interaction of DAXX with TP53, stimulates 'Ser-46' phosphorylation of TP53 and induces cell death on UV irradiation (By similarity). Also interacts with APC, RNF111, SMAD6 and SMAD7 (By similarity). Interacts (via the C-terminal) with PPP1CA; the interaction dephosphorylates AXIN1 and regulates interaction with GSK3B (By similarity). Interacts with PPP2CA; the interaction dephosphorylates AXIN1 (By similarity). Interacts with MDFI; the interaction decreases AXIN1-mediated JUN N-terminal kinase (JNK) activation (By similarity). Interacts with MDFIC; the interaction inhibits beta-cateninin-mediated signaling and AXIN1-mediated JUN N- terminal kinase (JNK) activation (By similarity). Binds ANKRD6, PIAS1, PIAS2, PIAS4, SUMO1, MAP3K1 and MAP3K4 (PubMed:12183362, PubMed:12223491). Component of the AXIN1-HIPK2-TP53 complex (PubMed:15526030). Interacts directly in the complex with TP53 and HIPK2 (PubMed:15526030). Interacts with DIXDC1; the interaction prevents interaction with MAP3K1 (PubMed:15262978). Interacts with AIDA; the interaction blocks the AXIN1-mediated JNK activation through disrupting AXIN1 homodimerization and Wnt signaling (PubMed:17681137). Interacts with LRP5 (via its phosphorylated PPPSP motifs); the interaction is stimulated by WNT1 and GSK3B and activates beta-catenin signaling (PubMed:11336703). Interacts with CTNNB1 (via the armadillo repeats 2-7) (PubMed:10581160, PubMed:15063782). Interacts with MACF1 (By similarity). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Interacts with TNKS (By similarity). Interacts with DAB2; the interaction is mutually exclusive with the AXIN1:PPP1CA interaction (PubMed:19581931). Interacts with ZBED3 (via PPPSP motif); the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations (PubMed:19141611). Interacts with WDR26 (By similarity). Interacts with GID8 (By similarity). Interacts with SIAH1 and SIAH2; both probably catalyze AXIN1 ubiquitination and subsequent proteasome-mediated ubiquitin- dependent degradation. Interaction with GSK3B and AXIN1 is competitive (By similarity). O35625; P98078: Dab2; NbExp=4; IntAct=EBI-2365912, EBI-1391846; O35625; Q61062: Dvl3; NbExp=2; IntAct=EBI-2365912, EBI-1538450; O35625; P62137: Ppp1ca; NbExp=2; IntAct=EBI-2365912, EBI-357187; O35625; Q99ML9: Rnf111; NbExp=4; IntAct=EBI-2365912, EBI-646015; O35625; Q8BUN5: Smad3; NbExp=2; IntAct=EBI-2365912, EBI-2337983; O35625; O35182: Smad6; NbExp=2; IntAct=EBI-2365912, EBI-4321242; O35625; O35253: Smad7; NbExp=2; IntAct=EBI-2365912, EBI-5274835; O35625; Q9EPK5: Wwtr1; NbExp=4; IntAct=EBI-2365912, EBI-1211920; O35625; P35222: CTNNB1; Xeno; NbExp=4; IntAct=EBI-2365912, EBI-491549; O35625; P49841: GSK3B; Xeno; NbExp=5; IntAct=EBI-2365912, EBI-373586; O35625; O75581: LRP6; Xeno; NbExp=2; IntAct=EBI-2365912, EBI-910915; O35625; Q15583: TGIF1; Xeno; NbExp=2; IntAct=EBI-2365912, EBI-714215; O35625; O95271: TNKS; Xeno; NbExp=4; IntAct=EBI-2365912, EBI-1105254; O35625; P46937: YAP1; Xeno; NbExp=3; IntAct=EBI-2365912, EBI-1044059; Cytoplasm cleus Cell membrane Membrane Note=On UV irradiation, translocates to the nucleus and colocalizes with DAAX (By similarity). MACF1 is required for its translocation to cell membrane (PubMed:16815997). Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O35625-1; Sequence=Displayed; Name=2; IsoId=O35625-2; Sequence=VSP_000452; Expressed in embryonic stem cells. Widely expressed at 10.5 dpc to 16.5 dpc. The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2. Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1 (By similarity). Also phosphorylated by CDK2 which regulates interaction with CTNBB1. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway (By similarity). Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important for nuclear accumulation during Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription (By similarity). Sumoylation at Lys-858 and Lys-861 prevents ubiquitination and degradation. Sumoylation is required for AXIN1-mediated JNK activation. Ubiquitination by SIAH1 and SIAH2 induces its proteasomal degradation as part of the activation of the Wnt signaling pathway (By similarity). Sequence=AAC53285.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; protein polyubiquitination in utero embryonic development regulation of protein phosphorylation positive regulation of protein phosphorylation p53 binding receptor binding protein binding nucleus cytoplasm cytosol plasma membrane cell cortex nucleocytoplasmic transport apoptotic process multicellular organism development sensory perception of sound beta-catenin binding protein C-terminus binding dorsal/ventral axis specification dorsal/ventral pattern formation negative regulation of gene expression positive regulation of peptidyl-threonine phosphorylation postsynaptic density membrane Wnt signaling pathway lateral plasma membrane enzyme binding protein kinase binding protein domain specific binding protein catabolic process negative regulation of Wnt signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway beta-catenin destruction complex cytoplasmic microtubule organization positive regulation of protein ubiquitination cytoplasmic vesicle ubiquitin protein ligase binding activation of protein kinase activity positive regulation of proteasomal ubiquitin-dependent protein catabolic process macromolecular complex positive regulation of peptidyl-serine phosphorylation negative regulation of transcription elongation from RNA polymerase II promoter cellular macromolecular complex assembly signaling adaptor activity post-anal tail morphogenesis identical protein binding protein homodimerization activity positive regulation of JUN kinase activity protein self-association negative regulation of fat cell differentiation positive regulation of protein catabolic process positive regulation of protein kinase activity positive regulation of transcription, DNA-templated positive regulation of JNK cascade SMAD binding axial mesoderm development axial mesoderm formation perinuclear region of cytoplasm negative regulation of protein metabolic process protein homooligomerization positive regulation of ubiquitin-protein transferase activity canonical Wnt signaling pathway binding, bridging head development regulation of canonical Wnt signaling pathway armadillo repeat domain binding I-SMAD binding R-SMAD binding genetic imprinting cell periphery negative regulation of canonical Wnt signaling pathway Wnt signalosome positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Golgi apparatus cytoplasmic microtubule uc315wrt.1